From d4989844c08388f3e68908008870b16608b5d59c Mon Sep 17 00:00:00 2001 From: mauricio Date: Wed, 10 Apr 2024 19:23:53 -0300 Subject: [PATCH 1/3] Update HMDD database to v4.0. Update Documentation and Tests --- .gitignore | 4 +- DEPLOYING.md | 21 +- ModulectorBackend/settings.py | 2 +- README.md | 2 +- docker-compose_dist.yml | 2 +- modulector/files/disease.txt | 35548 ---------- modulector/files/disease_hmdd.txt | 53554 ++++++++++++++++ .../migrations/0035_auto_20230112_2319.py | 2 +- .../migrations/0036_auto_20230116_2049.py | 4 +- .../migrations/0041_auto_20240410_1918.py | 48 + modulector/processors/disease_processor.py | 43 - modulector/tests/test_diseases.py | 13 +- 12 files changed, 53625 insertions(+), 35618 deletions(-) delete mode 100644 modulector/files/disease.txt create mode 100644 modulector/files/disease_hmdd.txt create mode 100644 modulector/migrations/0041_auto_20240410_1918.py delete mode 100644 modulector/processors/disease_processor.py diff --git a/.gitignore b/.gitignore index eede6b6..bc9e019 100644 --- a/.gitignore +++ b/.gitignore @@ -145,8 +145,8 @@ src/api_service/experiments/venv docker-compose.yml /secretkey.txt /modulector/database_versions/ -modulector/files/EPIC-8v2-0_A1.csv -modulector/files/mirDIP_Unidirectional_search_v.5.txt +modulector/files/EPIC.csv +modulector/files/mirDIP_Unidirectional_search.txt *.sql.gz modulector/files/tmp_db.csv docker-compose.mauri_dev.yml diff --git a/DEPLOYING.md b/DEPLOYING.md index f5610a9..f4f636d 100644 --- a/DEPLOYING.md +++ b/DEPLOYING.md @@ -134,28 +134,31 @@ You can use set Modulector DB in two ways. ### Regenerating the data manually -1. Download the files for the mirDIP database (version 5.2) and the Illumina 'Infinium MethylationEPIC 2.0' array. The files can be freely downloaded from their respective web pages. +1. Download the files for the mirDIP database (version 5.2), Illumina 'Infinium MethylationEPIC 2.0' array and the Human MicroRNA Disease Database v4.0. The files can be freely downloaded from their respective web pages. **For the mirDIP database**: - Go to the [MirDIP download web page](https://ophid.utoronto.ca/mirDIP/download.jsp) and download the file called *"mirDIPweb/mirDIP Unidirectional search ver. 5.2"*. - Unzip the file. - - Find the file called *"mirDIP_Unidirectional_search_v.5.txt"* and move it into the **"modulector/files/"** directory. + - Find the file called *"mirDIP_Unidirectional_search.txt"* and move it into the **"modulector/files/"** directory. **For the EPIC Methylation array**: - Go to the [Illumina product files web page](https://support.illumina.com/downloads/infinium-methylationepic-v2-0-product-files.html) and download the ZIP file called "*Infinium MethylationEPIC v2.0 Product Files (ZIP Format)*". - Unzip the file. - - Within the unzipped files you will find one called "*EPIC-8v2-0_A1.csv*". Move this file to the directory **"modulector/files/"**. - - **NOTE:** the total weight of both files is about 5 GB. + - Within the unzipped files you will find one called "*EPIC.csv*". Move this file to the directory **"modulector/files/"**. + - **NOTE:** the total weight of both files is about 5 GB. + + **For the HMDD database**: + - Go to the [HMDD website](https://www.cuilab.cn/hmdd) and from the *Downloads* tab, download the *txt* file from the option "The whole dataset of miRNA-disease association data". Use version 4.0. + - Rename the downloaded file as "*disease_hmdd.txt*". Move this file to the directory **"modulector/files/"**. **For the mirBase database**: this database is embedded as it weighs only a few MBs. Its data is processed in Django migrations during the execution of the `python3 manage.py migrate` command. So, you don't have to do manual steps to incorporate mirBase data inside Modulector. -1. Start up a PostgreSQL service. You can use the same service listed in the *docker-compose.dev.yml* file. -1. Run `python3 manage.py migrate` to apply all the migrations (**NOTE:** this can take a long time to finish). +2. Start up a PostgreSQL service. You can use the same service listed in the *docker-compose.dev.yml* file. +3. Run `python3 manage.py migrate` to apply all the migrations (**NOTE:** this can take a long time to finish). ## Update databases -Modulector currently works with the mirDIP (version 5.2) and miRBase (version 22.1) databases for miRNA data, and with information from the Illumina 'Infinium MethylationEPIC 2.0' array for information about methylation sites. -If new versions are released for these databases, and you want to update them, follow these steps: +If new versions of the databases used in modulector are released and you want to update them, follow the following steps: -- For **mirDIP** and **Illumina EPIC array** you must follow the same steps described in the [Regenerating the data manually](#regenerating-the-data-manually) section, replacing the named files with the most recent versions that have been published on their sites . +- For **mirDIP**, **HDMM** and **Illumina EPIC array** you must follow the same steps described in the [Regenerating the data manually](#regenerating-the-data-manually) section, replacing the named files with the most recent versions that have been published on their sites. - For **miRBase**, follow the instructions below: 1. Go to the [*Download* section on the website][mirbase-download-page]. 1. Download the files named *hairpin.fa* and *mature.fa* from the latest version of the database. diff --git a/ModulectorBackend/settings.py b/ModulectorBackend/settings.py index 9b683be..0a5b6f6 100644 --- a/ModulectorBackend/settings.py +++ b/ModulectorBackend/settings.py @@ -13,7 +13,7 @@ import os # Modulector version -VERSION: str = '2.1.4' +VERSION: str = '2.2.0' # Default primary key field type # https://docs.djangoproject.com/en/4.0/ref/settings/#default-auto-field diff --git a/README.md b/README.md index c990ceb..77fbba9 100644 --- a/README.md +++ b/README.md @@ -41,7 +41,7 @@ Modulector obtains information from different bioinformatics databases or resour 2. miRNA data: [miRBase: the microRNA database](https://mirbase.org/). miRBase is a searchable database of published miRNA sequences and annotations. Each entry in the miRBase Sequence database represents a predicted hairpin portion of a miRNA transcript (termed hairpin in the database), with information on the location and sequence of the mature miRNA sequence (termed mature). Modulector use miRBase 22.1. 3. Relationship data between miRNA and diseases: [HMDD: the Human microRNA Disease Database](https://www.cuilab.cn/hmdd). - Increasing reports have shown that miRNAs play important roles in various critical biological processes. For their importance, the dysfunctions of miRNAs are associated with a broad spectrum of diseases. The Human microRNA Disease Database (HMDD) is a database that curated experiment-supported evidence for human microRNA (miRNA) and disease associations. Modulector use HMDD v3.2 . + Increasing reports have shown that miRNAs play important roles in various critical biological processes. For their importance, the dysfunctions of miRNAs are associated with a broad spectrum of diseases. The Human microRNA Disease Database (HMDD) is a database that curated experiment-supported evidence for human microRNA (miRNA) and disease associations. Modulector use HMDD v4.0. 4. Relationship data between miRNA and drugs: [SM2miR Database](http://www.jianglab.cn/SM2miR/). Many studies have demonstrated that bioactive small molecules (or drugs) can regulate the miRNA expression, which indicate that targeting miRNAs with small molecules is a new type of therapy for human diseases. SM2miR is a manual curated database which collects and incorporates the experimentally validated small molecules' effects on miRNA expression in 21 species from the published papers. Modulector uses leaked data from the SM2miR database for Homo Sapiens, in the version released on Apr. 27, 2015. 5. Methylation data: Illumina [Infinium MethylationEPIC 2.0](https://www.illumina.com/products/by-type/microarray-kits/infinium-methylation-epic.html) array. diff --git a/docker-compose_dist.yml b/docker-compose_dist.yml index 77881d9..da1e05e 100644 --- a/docker-compose_dist.yml +++ b/docker-compose_dist.yml @@ -31,7 +31,7 @@ services: # Django Backend Server web_modulector: - image: omicsdatascience/modulector:2.1.4 + image: omicsdatascience/modulector:2.2.0 restart: always depends_on: - db_modulector diff --git a/modulector/files/disease.txt b/modulector/files/disease.txt deleted file mode 100644 index a616d20..0000000 --- a/modulector/files/disease.txt +++ /dev/null @@ -1,35548 +0,0 @@ -category mir disease pmid description -circulation_biomarker_diagnosis_down hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 15737576 Some human miRNAs are linked to leukemias: the miR-15a/miR-16 locus is frequently deleted or down-regulated in patients with B-cell chronic lymphocytic leukemia and miR-142 is at a translocation site found in a case of aggressive B-cell leukemia. -circulation_biomarker_diagnosis_down hsa-mir-16 "Leukemia, Lymphocytic, Chronic, B-Cell" 15737576 Some human miRNAs are linked to leukemias: the miR-15a/miR-16 locus is frequently deleted or down-regulated in patients with B-cell chronic lymphocytic leukemia and miR-142 is at a translocation site found in a case of aggressive B-cell leukemia. -circulation_biomarker_diagnosis_down hsa-mir-143 Colon Neoplasms 16195701 downregulation -circulation_biomarker_diagnosis_down hsa-mir-145 Colon Neoplasms 16195701 downregulation -circulation_biomarker_diagnosis_down hsa-mir-223 "Leukemia, Lymphocytic, Chronic, B-Cell" 16251535 downregulated -circulation_biomarker_diagnosis_down hsa-mir-29a "Leukemia, Lymphocytic, Chronic, B-Cell" 16251535 downregulated -circulation_biomarker_diagnosis_down hsa-mir-29c "Leukemia, Lymphocytic, Chronic, B-Cell" 16251535 downregulated -circulation_biomarker_diagnosis_down hsa-mir-10b Breast Neoplasms 16466964 down-regulated -circulation_biomarker_diagnosis_down hsa-mir-125b-1 Breast Neoplasms 16466964 down-regulated -circulation_biomarker_diagnosis_down hsa-mir-125b-2 Breast Neoplasms 16466964 down-regulated -circulation_biomarker_diagnosis_down hsa-mir-145 Breast Neoplasms 16466964 down-regulated -circulation_biomarker_diagnosis_down hsa-mir-106 Leukemia 16549775 "we performed microRNA expression profiling of in vitro-differentiated megakaryocytes derived from CD34(+) hematopoietic progenitors. The main finding was down-regulation of miR-10a, miR-126, miR-106, miR-10b, miR-17 and miR-20." -circulation_biomarker_diagnosis_down hsa-mir-10a Leukemia 16549775 "we performed microRNA expression profiling of in vitro-differentiated megakaryocytes derived from CD34(+) hematopoietic progenitors. The main finding was down-regulation of miR-10a, miR-126, miR-106, miR-10b, miR-17 and miR-20." -circulation_biomarker_diagnosis_down hsa-mir-10b Leukemia 16549775 "we performed microRNA expression profiling of in vitro-differentiated megakaryocytes derived from CD34(+) hematopoietic progenitors. The main finding was down-regulation of miR-10a, miR-126, miR-106, miR-10b, miR-17 and miR-20." -circulation_biomarker_diagnosis_down hsa-mir-126 Leukemia 16549775 "we performed microRNA expression profiling of in vitro-differentiated megakaryocytes derived from CD34(+) hematopoietic progenitors. The main finding was down-regulation of miR-10a, miR-126, miR-106, miR-10b, miR-17 and miR-20." -circulation_biomarker_diagnosis_down hsa-mir-17 Leukemia 16549775 "we performed microRNA expression profiling of in vitro-differentiated megakaryocytes derived from CD34(+) hematopoietic progenitors. The main finding was down-regulation of miR-10a, miR-126, miR-106, miR-10b, miR-17 and miR-20." -circulation_biomarker_diagnosis_down hsa-mir-20 Leukemia 16549775 "we performed microRNA expression profiling of in vitro-differentiated megakaryocytes derived from CD34(+) hematopoietic progenitors. The main finding was down-regulation of miR-10a, miR-126, miR-106, miR-10b, miR-17 and miR-20." -circulation_biomarker_diagnosis_down hsa-let-7a-1 Lung Neoplasms 16712479 downregulation -circulation_biomarker_diagnosis_down hsa-let-7a-2 Lung Neoplasms 16712479 downregulation -circulation_biomarker_diagnosis_down hsa-let-7a-3 Lung Neoplasms 16712479 downregulation -circulation_biomarker_diagnosis_down hsa-let-7b Lung Neoplasms 16712479 downregulation -circulation_biomarker_diagnosis_down hsa-let-7c Lung Neoplasms 16712479 downregulation -circulation_biomarker_diagnosis_down hsa-let-7d Lung Neoplasms 16712479 downregulation -circulation_biomarker_diagnosis_down hsa-let-7e Lung Neoplasms 16712479 downregulation -circulation_biomarker_diagnosis_down hsa-let-7f-1 Lung Neoplasms 16712479 downregulation -circulation_biomarker_diagnosis_down hsa-let-7f-2 Lung Neoplasms 16712479 downregulation -circulation_biomarker_diagnosis_down hsa-let-7g Lung Neoplasms 16712479 downregulation -circulation_biomarker_diagnosis_down hsa-let-7i Lung Neoplasms 16712479 downregulation -circulation_biomarker_diagnosis_down hsa-mir-143 Colorectal Carcinoma 16847880 reduced -circulation_biomarker_diagnosis_down hsa-mir-145 Colorectal Carcinoma 16847880 reduced -circulation_biomarker_diagnosis_down hsa-mir-181a-2 "Leukemia, Promyelocytic, Acute" 16847880 miR-181 expression is decreased inTPA-induced differentiation of human promyelocytic leukemia cells. -circulation_biomarker_diagnosis_down hsa-mir-181b-1 "Leukemia, Promyelocytic, Acute" 16847880 miR-181 expression is decreased inTPA-induced differentiation of human promyelocytic leukemia cells. -circulation_biomarker_diagnosis_down hsa-mir-181b-2 "Leukemia, Promyelocytic, Acute" 16847880 miR-181 expression is decreased inTPA-induced differentiation of human promyelocytic leukemia cells. -circulation_biomarker_diagnosis_down hsa-mir-181d "Leukemia, Promyelocytic, Acute" 16847880 miR-181 expression is decreased inTPA-induced differentiation of human promyelocytic leukemia cells. -circulation_biomarker_diagnosis_down hsa-mir-143 Colon Neoplasms 16885332 miR-143 and miR-145 expression is reduced. -circulation_biomarker_diagnosis_down hsa-mir-145 Breast Neoplasms 16885332 Reduced expression in breast cancers -circulation_biomarker_diagnosis_down hsa-mir-155 Neoplasms [unspecific] 16885332 "High expression of precursor miR-155/BIC in pediatric BL, but lack of BIC and miR-155 expression in adult BL" -circulation_biomarker_diagnosis_down hsa-mir-143 Colon Neoplasms 16940181 Downregulation of Mir-143 and Mir-145 has been observed in colorectal cancer. -circulation_biomarker_diagnosis_down hsa-mir-145 Colon Neoplasms 16940181 Downregulation of Mir-143 and Mir-145 has beenobserved in colorectal cancer. -circulation_biomarker_diagnosis_down hsa-mir-15a Pituitary Neoplasms 17028302 Downregulation of miR-15 and miR-16 miRNAs also appears to be a feature of pituitary adenomas. -circulation_biomarker_diagnosis_down hsa-mir-15b Pituitary Neoplasms 17028302 Downregulation of miR-15 and miR-16 miRNAs also appears to be a feature of pituitary adenomas. -circulation_biomarker_diagnosis_down hsa-mir-16-1 Pituitary Neoplasms 17028302 Downregulation of miR-15 and miR-16 miRNAs also appears to be a feature of pituitary adenomas. -circulation_biomarker_diagnosis_down hsa-mir-16-2 Pituitary Neoplasms 17028302 Downregulation of miR-15 and miR-16 miRNAs also appears to be a feature of pituitary adenomas. -circulation_biomarker_diagnosis_down hsa-let-7a-1 Lung Neoplasms 17096367 Recent study demonstrated that the expression of let-7 was significantly reduced while the expression of RAS was dramatically increased in lung tumor tissues. -circulation_biomarker_diagnosis_down hsa-let-7a-2 Lung Neoplasms 17096367 Recent study demonstrated that the expression of let-7 was significantly reduced while the expression of RAS was dramatically increased in lung tumor tissues. -circulation_biomarker_diagnosis_down hsa-let-7a-3 Lung Neoplasms 17096367 Recent study demonstrated that the expression of let-7 was significantly reduced while the expression of RAS was dramatically increased in lung tumor tissues. -circulation_biomarker_diagnosis_down hsa-let-7b Lung Neoplasms 17096367 Recent study demonstrated that the expression of let-7 was significantly reduced while the expression of RAS was dramatically increased in lung tumor tissues. -circulation_biomarker_diagnosis_down hsa-let-7c Lung Neoplasms 17096367 Recent study demonstrated that the expression of let-7 was significantly reduced while the expression of RAS was dramatically increased in lung tumor tissues. -circulation_biomarker_diagnosis_down hsa-let-7d Lung Neoplasms 17096367 Recent study demonstrated that the expression of let-7 was significantly reduced while the expression of RAS was dramatically increased in lung tumor tissues. -circulation_biomarker_diagnosis_down hsa-let-7e Lung Neoplasms 17096367 Recent study demonstrated that the expression of let-7 was significantly reduced while the expression of RAS was dramatically increased in lung tumor tissues. -circulation_biomarker_diagnosis_down hsa-let-7f-1 Lung Neoplasms 17096367 Recent study demonstrated that the expression of let-7 was significantly reduced while the expression of RAS was dramatically increased in lung tumor tissues. -circulation_biomarker_diagnosis_down hsa-let-7f-2 Lung Neoplasms 17096367 Recent study demonstrated that the expression of let-7 was significantly reduced while the expression of RAS was dramatically increased in lung tumor tissues. -circulation_biomarker_diagnosis_down hsa-let-7g Lung Neoplasms 17096367 Recent study demonstrated that the expression of let-7 was significantly reduced while the expression of RAS was dramatically increased in lung tumor tissues. -circulation_biomarker_diagnosis_down hsa-let-7i Lung Neoplasms 17096367 Recent study demonstrated that the expression of let-7 was significantly reduced while the expression of RAS was dramatically increased in lung tumor tissues. -circulation_biomarker_diagnosis_down hsa-let-7e "Carcinoma, Hepatocellular" 17188425 "Independent observations showed that the expression of miRNAs let-7e, 125a and 99b, located at 19q13.4, were considerably lower in HCC compared to nontumor liver [59] and [65]. Given that miRNA-125a targets expression of the mitochondrial tumor suppressor gene, MTSG1, and RAR|§Ú§Ó, chromosomal instability in and around FRA19A may extinguish expression of these tumor suppressor genes." -circulation_biomarker_diagnosis_down hsa-mir-125a "Carcinoma, Hepatocellular" 17188425 "Independent observations showed that the expression of miRNAs let-7e, 125a and 99b, located at 19q13.4, were considerably lower in HCC compared to nontumor liver [59] and [65]. Given that miRNA-125a targets expression of the mitochondrial tumor suppressor gene, MTSG1, and RAR|§Ú§Ó, chromosomal instability in and around FRA19A may extinguish expression of these tumor suppressor genes." -circulation_biomarker_diagnosis_down hsa-mir-99b "Carcinoma, Hepatocellular" 17188425 "Independent observations showed that the expression of miRNAs let-7e, 125a and 99b, located at 19q13.4, were considerably lower in HCC compared to nontumor liver [59] and [65]. Given that miRNA-125a targets expression of the mitochondrial tumor suppressor gene, MTSG1, and RAR|§Ú§Ó, chromosomal instability in and around FRA19A may extinguish expression of these tumor suppressor genes." -circulation_biomarker_diagnosis_down hsa-mir-1-1 "Cardiomyopathy, Hypertrophic" 17234972 "Significantly,the muscle-specific microRNA-1 (miR-1) was singularly downregulatedas early as day 1, persisting through day7, after aortic constriction Cinduced hypertrophy in a mouse model." -circulation_biomarker_diagnosis_down hsa-mir-1-2 "Cardiomyopathy, Hypertrophic" 17234972 "Significantly,the muscle-specific microRNA-1 (miR-1) was singularly downregulatedas early as day 1, persisting through day7, after aortic constriction Cinduced hypertrophy in a mouse model." -circulation_biomarker_diagnosis_down hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 17327404 "Both approaches show that miR-21 and miR-155 are dramatically overexpressed in patients with CLL, although the corresponding genomic loci are not amplified. miR-150 and miR-92 are also significantly deregulated in patients with CLL. In addition, we detected a marked miR-15a and miR-16 decrease in about 11% of cases" -circulation_biomarker_diagnosis_down hsa-mir-16 "Leukemia, Lymphocytic, Chronic, B-Cell" 17327404 "Both approaches show that miR-21 and miR-155 are dramatically overexpressed in patients with CLL, although the corresponding genomic loci are not amplified. miR-150 and miR-92 are also significantly deregulated in patients with CLL. In addition, we detected a marked miR-15a and miR-16 decrease in about 11% of cases" -circulation_biomarker_diagnosis_down hsa-mir-127 Thyroid Neoplasms 17355635 "three miRNAs showed significantly more underexpression compared to the other downregulated miRNAs. These miRNAs are as follows mir-127, mir-130a and mir-144." -circulation_biomarker_diagnosis_down hsa-mir-130a Thyroid Neoplasms 17355635 "three miRNAs showed significantly more underexpression compared to the other downregulated miRNAs. These miRNAs are as follows mir-127, mir-130a and mir-144." -circulation_biomarker_diagnosis_down hsa-mir-144 Thyroid Neoplasms 17355635 "three miRNAs showed significantly more underexpression compared to the other downregulated miRNAs. These miRNAs are as follows mir-127, mir-130a and mir-144." -circulation_biomarker_diagnosis_down hsa-mir-17 Breast Neoplasms 17442096 "In breast cancer cells, mir-17-5p expression is decreased." -circulation_biomarker_diagnosis_down hsa-mir-1-1 "Cardiomyopathy, Hypertrophic" 17468766 downregulation -circulation_biomarker_diagnosis_down hsa-mir-1-2 "Cardiomyopathy, Hypertrophic" 17468766 downregulation -circulation_biomarker_diagnosis_down hsa-mir-133a-1 "Cardiomyopathy, Hypertrophic" 17468766 downregulation -circulation_biomarker_diagnosis_down hsa-mir-133a-2 "Cardiomyopathy, Hypertrophic" 17468766 downregulation -circulation_biomarker_diagnosis_down hsa-mir-1-1 "Cardiomyopathy, Hypertrophic" 17479098 "The researchers showed that expression of miR-1 and another muscle-specific miRNA, miR-133, is decreased in human and mouse hypertrophic heart tissue." -circulation_biomarker_diagnosis_down hsa-mir-1-2 "Cardiomyopathy, Hypertrophic" 17479098 "The researchers showed that expression of miR-1 and another muscle-specific miRNA, miR-133, is decreased in human and mouse hypertrophic heart tissue." -circulation_biomarker_diagnosis_down hsa-mir-133a-1 "Cardiomyopathy, Hypertrophic" 17479098 "The researchers showed that expression of miR-1 and another muscle-specific miRNA, miR-133, is decreased in human and mouse hypertrophic heart tissue." -circulation_biomarker_diagnosis_down hsa-mir-133a-2 "Cardiomyopathy, Hypertrophic" 17479098 "The researchers showed that expression of miR-1 and another muscle-specific miRNA, miR-133, is decreased in human and mouse hypertrophic heart tissue." -circulation_biomarker_diagnosis_down hsa-mir-148a Asthma 17847008 "Previously, we identified HLA-G as an asthma-susceptibility gene and discovered that the risk of asthma in a child was determined by both the child's HLA-G genotype and the mother's affection status. The activity of pluc-HLAG-G in the presence of each of the three miRNAs was significantly lower than those of pluc-HLAG-C and pluc-HLA-G-Del." -circulation_biomarker_diagnosis_down hsa-mir-148b Asthma 17847008 "Previously, we identified HLA-G as an asthma-susceptibility gene and discovered that the risk of asthma in a child was determined by both the child's HLA-G genotype and the mother's affection status. The activity of pluc-HLAG-G in the presence of each of the three miRNAs was significantly lower than those of pluc-HLAG-C and pluc-HLA-G-Del." -circulation_biomarker_diagnosis_down hsa-mir-152 Asthma 17847008 "Previously, we identified HLA-G as an asthma-susceptibility gene and discovered that the risk of asthma in a child was determined by both the child's HLA-G genotype and the mother's affection status. The activity of pluc-HLAG-G in the presence of each of the three miRNAs was significantly lower than those of pluc-HLAG-C and pluc-HLA-G-Del." -circulation_biomarker_diagnosis_down hsa-mir-143 "Lymphoma, B-Cell" 17892514 Downregulation of microRNAs-143 and -145 in B-cell malignancies. -circulation_biomarker_diagnosis_down hsa-mir-143 Breast Neoplasms 17940623 "Studies have implicated other miRNAs in tumorigenesis. MiR-143 and miR-145, for instance, have been shown to be constantly down-regulated in colorectal tumors, and recent studies by Croce et al. also have shown that the downregulation of these miRNAs is a common occurrence in breast carcinomas and breast cancer lines." -circulation_biomarker_diagnosis_down hsa-mir-143 Colon Neoplasms 17940623 "Studies have implicated other miRNAs in tumorigenesis. MiR-143 and miR-145, for instance, have been shown to be constantly down-regulated in colorectal tumors, and recent studies by Croce et al. also have shown that the downregulation of these miRNAs is a common occurrence in breast carcinomas and breast cancer lines." -circulation_biomarker_diagnosis_down hsa-mir-145 Breast Neoplasms 17940623 "Studies have implicated other miRNAs in tumorigenesis. MiR-143 and miR-145, for instance, have been shown to be constantly down-regulated in colorectal tumors, and recent studies by Croce et al. also have shown that the downregulation of these miRNAs is a common occurrence in breast carcinomas and breast cancer lines." -circulation_biomarker_diagnosis_down hsa-mir-145 Colon Neoplasms 17940623 "Studies have implicated other miRNAs in tumorigenesis. MiR-143 and miR-145, for instance, have been shown to be constantly down-regulated in colorectal tumors, and recent studies by Croce et al. also have shown that the downregulation of these miRNAs is a common occurrence in breast carcinomas and breast cancer lines." -circulation_biomarker_diagnosis_down hsa-mir-17 Breast Neoplasms 17965831 "miR-17-5p was down-regulated in breast cancer cells, and enhanced expression decreased tumour cell proliferation." -circulation_biomarker_diagnosis_down hsa-let-7a-3 Ovarian Neoplasms 17974952 decreased -circulation_biomarker_diagnosis_down hsa-mir-150 Polycythemia Vera 17976518 "Comparative analyses of control and PV EPs suggested increased levels of miR-451, miR-16, miR-21, and miR-26b and decreased levels of miR-150 and miR-221 in PV group, Expression of miR-150 progressively declined with erythroid differentiation, its expression decreased ninefold (p < 0.05) from days 7 to 11." -circulation_biomarker_diagnosis_down hsa-mir-155 Polycythemia Vera 17976518 "Comparative analyses of control and PV EPs suggested increased levels of miR-451, miR-16, miR-21, and miR-26b and decreased levels of miR-150 and miR-221 in PV group, Expression of miR-150 progressively declined with erythroid differentiation, its expression decreased ninefold (p < 0.05) from days 7 to 11." -circulation_biomarker_diagnosis_down hsa-mir-221 Polycythemia Vera 17976518 "Comparative analyses of control and PV EPs suggested increased levels of miR-451, miR-16, miR-21, and miR-26b and decreased levels of miR-150 and miR-221 in PV group, Expression of miR-150 progressively declined with erythroid differentiation, its expression decreased ninefold (p < 0.05) from days 7 to 11." -circulation_biomarker_diagnosis_down hsa-let-7b "Leukemia, Myeloid, Acute" 18056805 "Among them, miR-128a and -128b are significantly overexpressed, whereas let-7b and miR-223 are significantly down-regulated in ALL compared with AML." -circulation_biomarker_diagnosis_down hsa-mir-223 "Leukemia, Lymphoblastic" 18056805 "Among them, miR-128a and -128b are significantly overexpressed, whereas let-7b and miR-223 are significantly down-regulated in ALL compared with AML." -circulation_biomarker_diagnosis_down hsa-mir-128-1 "Lymphoma, Hodgkin" 18089852 down-regulated -circulation_biomarker_diagnosis_down hsa-mir-128-2 "Lymphoma, Hodgkin" 18089852 down-regulated -circulation_biomarker_diagnosis_down hsa-mir-96 "Lymphoma, Hodgkin" 18089852 down-regulated -circulation_biomarker_diagnosis_down hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 18362358 lost or downregulated -circulation_biomarker_diagnosis_down hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 18362358 lost or downregulated -circulation_biomarker_diagnosis_down hsa-mir-29c Nasopharyngeal Neoplasms 18390668 down-regulated -circulation_biomarker_diagnosis_down hsa-mir-199a-1 Neoplasms [unspecific] 18430245 decreased -circulation_biomarker_diagnosis_down hsa-let-7a Polycythemia Vera 18508790 "We observed down-regulation of let-7a and up-regulation of miR-182 in polycythemia vera granulocytes, up-regulation of miR-143, miR-145 and miR-223 in polycythemia vera mononuclear cells, up-regulation of miR-26b in polycythemia vera platelets, and down-regulation of miR-30b, miR-30c and miR-150 in polycythemia vera reticulocytes." -circulation_biomarker_diagnosis_down hsa-mir-150 Polycythemia Vera 18508790 "We observed down-regulation of let-7a and up-regulation of miR-182 in polycythemia vera granulocytes, up-regulation of miR-143, miR-145 and miR-223 in polycythemia vera mononuclear cells, up-regulation of miR-26b in polycythemia vera platelets, and down-regulation of miR-30b, miR-30c and miR-150 in polycythemia vera reticulocytes." -circulation_biomarker_diagnosis_down hsa-mir-30b Polycythemia Vera 18508790 "We observed down-regulation of let-7a and up-regulation of miR-182 in polycythemia vera granulocytes, up-regulation of miR-143, miR-145 and miR-223 in polycythemia vera mononuclear cells, up-regulation of miR-26b in polycythemia vera platelets, and down-regulation of miR-30b, miR-30c and miR-150 in polycythemia vera reticulocytes." -circulation_biomarker_diagnosis_down hsa-mir-30c Polycythemia Vera 18508790 "We observed down-regulation of let-7a and up-regulation of miR-182 in polycythemia vera granulocytes, up-regulation of miR-143, miR-145 and miR-223 in polycythemia vera mononuclear cells, up-regulation of miR-26b in polycythemia vera platelets, and down-regulation of miR-30b, miR-30c and miR-150 in polycythemia vera reticulocytes." -circulation_biomarker_diagnosis_down hsa-mir-222 Breast Neoplasms 18777135 miR-222: decreased expression in c-Myc induced mouse mammary tumors -circulation_biomarker_diagnosis_down hsa-let-7e Ovarian Neoplasms 18823650 let-7e: deregulated -circulation_biomarker_diagnosis_down hsa-mir-182 Retinal Degeneration 18834879 miR-182: decreased expression -circulation_biomarker_diagnosis_down hsa-mir-183 Retinal Degeneration 18834879 miR-183: decreased expression -circulation_biomarker_diagnosis_down hsa-mir-96 Retinal Degeneration 18834879 miR-96: decreased expression -circulation_biomarker_diagnosis_down hsa-mir-141 "Carcinoma, Renal Cell" 18925646 miR-141: down-regulation -circulation_biomarker_diagnosis_down hsa-mir-200c "Carcinoma, Renal Cell" 18925646 miR-200c: down-regulation -circulation_biomarker_diagnosis_down hsa-mir-125b-1 Myelodysplastic Syndromes 18936236 miR-125b-1: Myeloid cell differentiation arrest by miR-125b-1 -circulation_biomarker_diagnosis_down hsa-mir-17 "Lymphoma, B-Cell" 18941111 miR-17: down-regulates expression of distinct targets -circulation_biomarker_diagnosis_down hsa-mir-18a "Lymphoma, B-Cell" 18941111 miR-18a: down-regulates expression of distinct targets -circulation_biomarker_diagnosis_down hsa-mir-19a "Lymphoma, B-Cell" 18941111 miR-19a: down-regulates expression of distinct targets -circulation_biomarker_diagnosis_down hsa-mir-19b-1 "Lymphoma, B-Cell" 18941111 miR-19b: down-regulates expression of distinct targets -circulation_biomarker_diagnosis_down hsa-mir-19b-2 "Lymphoma, B-Cell" 18941111 miR-19b: down-regulates expression of distinct targets -circulation_biomarker_diagnosis_down hsa-mir-20a "Lymphoma, B-Cell" 18941111 miR-20a: down-regulates expression of distinct targets -circulation_biomarker_diagnosis_down hsa-mir-92a-1 "Lymphoma, B-Cell" 18941111 miR-92a: down-regulates expression of distinct targets -circulation_biomarker_diagnosis_down hsa-mir-92a-2 "Lymphoma, B-Cell" 18941111 miR-92a: down-regulates expression of distinct targets -circulation_biomarker_diagnosis_down hsa-mir-127 "Carcinoma, Hepatocellular" 18942116 miR-127: Down-regulation during hepatocarcinogenesis induced by a methyl-deficient diet -circulation_biomarker_diagnosis_down hsa-mir-200b "Carcinoma, Hepatocellular" 18942116 miR-200b: Down-regulation during hepatocarcinogenesis induced by a methyl-deficient diet -circulation_biomarker_diagnosis_down hsa-mir-34a "Carcinoma, Hepatocellular" 18942116 miR-34a: Down-regulation during hepatocarcinogenesis induced by a methyl-deficient diet -circulation_biomarker_diagnosis_down hsa-mir-337 Neurodegenerative Diseases [unspecific] 18987751 miR-337-3p: down-regulated -circulation_biomarker_diagnosis_down hsa-mir-338 Neurodegenerative Diseases [unspecific] 18987751 miR-338-3p: down-regulated -circulation_biomarker_diagnosis_down hsa-mir-150 Lupus Vulgaris 18998140 miR-150: downregulation -circulation_biomarker_diagnosis_down hsa-mir-210 Lupus Vulgaris 18998140 miR-210: downregulation -circulation_biomarker_diagnosis_down hsa-mir-223 Lupus Vulgaris 18998140 miR-223: downregulation -circulation_biomarker_diagnosis_down hsa-mir-296 Lupus Vulgaris 18998140 miR-296: downregulation -circulation_biomarker_diagnosis_down hsa-mir-30d Lupus Vulgaris 18998140 miR-30d: downregulation -circulation_biomarker_diagnosis_down hsa-mir-324 Lupus Vulgaris 18998140 miR-324-3p: downregulation -circulation_biomarker_diagnosis_down hsa-mir-346 Lupus Vulgaris 18998140 miR-346: downregulation -circulation_biomarker_diagnosis_down hsa-mir-365a Lupus Vulgaris 18998140 miR-365: downregulation -circulation_biomarker_diagnosis_down hsa-mir-365b Lupus Vulgaris 18998140 miR-365: downregulation -circulation_biomarker_diagnosis_down hsa-mir-423 Lupus Vulgaris 18998140 miR-423: downregulation -circulation_biomarker_diagnosis_down hsa-mir-484 Lupus Vulgaris 18998140 miR-484: downregulation -circulation_biomarker_diagnosis_down hsa-mir-486 Lupus Vulgaris 18998140 miR-486: downregulation -circulation_biomarker_diagnosis_down hsa-mir-500a Lupus Vulgaris 18998140 miR-500: downregulation -circulation_biomarker_diagnosis_down hsa-mir-518b Lupus Vulgaris 18998140 miR-518b: downregulation -circulation_biomarker_diagnosis_down hsa-mir-557 Lupus Vulgaris 18998140 miR-557: downregulation -circulation_biomarker_diagnosis_down hsa-mir-596 Lupus Vulgaris 18998140 miR-596: downregulation -circulation_biomarker_diagnosis_down hsa-mir-602 Lupus Vulgaris 18998140 miR-602: downregulation -circulation_biomarker_diagnosis_down hsa-mir-611 Lupus Vulgaris 18998140 miR-611: downregulation -circulation_biomarker_diagnosis_down hsa-mir-615 Lupus Vulgaris 18998140 miR-615: downregulation -circulation_biomarker_diagnosis_down hsa-mir-629 Lupus Vulgaris 18998140 miR-629: downregulation -circulation_biomarker_diagnosis_down hsa-mir-637 Lupus Vulgaris 18998140 miR-637: downregulation -circulation_biomarker_diagnosis_down hsa-mir-642a Lupus Vulgaris 18998140 miR-642: downregulation -circulation_biomarker_diagnosis_down hsa-mir-654 Lupus Vulgaris 18998140 miR-654: downregulation -circulation_biomarker_diagnosis_down hsa-mir-663a Lupus Vulgaris 18998140 miR-663: downregulation -circulation_biomarker_diagnosis_down hsa-mir-769 Lupus Vulgaris 18998140 miR-769-3p: downregulation -circulation_biomarker_diagnosis_down hsa-mir-99a Lupus Vulgaris 18998140 miR-99a: downregulation -circulation_biomarker_diagnosis_down hsa-mir-181a-2 Leukemia 19022373 miR-181a*: downregulated during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal -circulation_biomarker_diagnosis_down hsa-mir-199b Leukemia 19022373 miR-199b: downregulated during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal -circulation_biomarker_diagnosis_down hsa-mir-378a Leukemia 19022373 miR-378: downregulated during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal -circulation_biomarker_diagnosis_down hsa-mir-454 Leukemia 19022373 miR-454-3p: downregulated during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal -circulation_biomarker_diagnosis_down hsa-mir-575 Leukemia 19022373 miR-575: downregulated during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal -circulation_biomarker_diagnosis_down hsa-mir-10a "Leukemia, Myeloid, Chronic-Phase" 19074828 miR-10a: Down-regulation of hsa-miR-10a in chronic myeloid leukemia CD34+ cells increases USF2-mediated cell growth -circulation_biomarker_diagnosis_down hsa-mir-22 "Leukemia, Lymphocytic, Chronic, B-Cell" 19144983 miR-22: downregulation has in vivo significance in chronic lymphocytic leukemia and improves disease risk stratification -circulation_biomarker_diagnosis_down hsa-mir-29c "Leukemia, Lymphocytic, Chronic, B-Cell" 19144983 miR-29c: downregulation has in vivo significance in chronic lymphocytic leukemia and improves disease risk stratification -circulation_biomarker_diagnosis_down hsa-mir-373 "Leukemia-Lymphoma, Precursor B-Cell Lymphoblastic" 19206004 miR-373*: down-regulated -circulation_biomarker_diagnosis_down hsa-mir-451a "Leukemia-Lymphoma, Precursor B-Cell Lymphoblastic" 19206004 miR-451: down-regulated -circulation_biomarker_diagnosis_down hsa-mir-143 Colorectal Carcinoma 19242066 miR-143: only down-regulated in colon cancer but not in rectal cancer -circulation_biomarker_diagnosis_down hsa-mir-145 Colorectal Carcinoma 19242066 miR-145: down-regulated in both colon and rectal cancer -circulation_biomarker_diagnosis_down hsa-mir-346 Schizophrenia 19264453 miR-346: Expression of both miR-346 and GRID1 is lower in SZ patients than that in normal controls -circulation_biomarker_diagnosis_down hsa-mir-150 Marek Disease 19297609 miR-150: down-regulated -circulation_biomarker_diagnosis_down hsa-mir-223 Marek Disease 19297609 miR-223: down-regulated -circulation_biomarker_diagnosis_down hsa-mir-363 Autistic Disorder 19360674 miR-363: downregulated -circulation_biomarker_diagnosis_down hsa-mir-92a-1 Autistic Disorder 19360674 miR-92a-1: downregulated -circulation_biomarker_diagnosis_down hsa-mir-92a-2 Autistic Disorder 19360674 miR-92a-2: downregulated -circulation_biomarker_diagnosis_down hsa-mir-181b-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 19717645 "low expression of the miR-223, miR-29c, miR-29b, and miR-181 family were strongly associated with disease progression in CLL cases harboring 17p deletion" -circulation_biomarker_diagnosis_down hsa-mir-181b-2 "Leukemia, Lymphocytic, Chronic, B-Cell" 19717645 "low expression of the miR-223, miR-29c, miR-29b, and miR-181 family were strongly associated with disease progression in CLL cases harboring 17p deletion" -circulation_biomarker_diagnosis_down hsa-mir-181c "Leukemia, Lymphocytic, Chronic, B-Cell" 19717645 "low expression of the miR-223, miR-29c, miR-29b, and miR-181 family were strongly associated with disease progression in CLL cases harboring 17p deletion" -circulation_biomarker_diagnosis_down hsa-mir-223 "Leukemia, Lymphocytic, Chronic, B-Cell" 19717645 "low expression of the miR-223, miR-29c, miR-29b, and miR-181 family were strongly associated with disease progression in CLL cases harboring 17p deletion" -circulation_biomarker_diagnosis_down hsa-mir-29b-2 "Leukemia, Lymphocytic, Chronic, B-Cell" 19717645 "low expression of the miR-223, miR-29c, miR-29b, and miR-181 family were strongly associated with disease progression in CLL cases harboring 17p deletion" -circulation_biomarker_diagnosis_down hsa-mir-145 Atherosclerosis 19744308 downregulated -circulation_biomarker_diagnosis_down hsa-mir-150 Sepsis 19823581 miR-150 as a plasma prognostic marker in patients with sepsis -circulation_biomarker_diagnosis_down hsa-mir-199b Choriocarcinoma 19900756 miR-199b:Decreased expression of microRNA-199b increases protein levels of SET (protein phosphatase 2A inhibitor) in human choriocarcinoma -circulation_biomarker_diagnosis_down hsa-mir-146a Sepsis 20188071 Serum miR-146a and miR-223 as potential new biomarkers for sepsis -circulation_biomarker_diagnosis_down hsa-mir-223 Sepsis 20188071 Serum miR-146a and miR-223 as potential new biomarkers for sepsis -circulation_biomarker_diagnosis_down hsa-mir-200a Glomerulonephritis 20364043 down-regulated -circulation_biomarker_diagnosis_down hsa-mir-200b Glomerulonephritis 20364043 down-regulated -circulation_biomarker_diagnosis_down hsa-mir-429 Glomerulonephritis 20364043 down-regulated -circulation_biomarker_diagnosis_down hsa-mir-106b "Child Development Disorders, Pervasive" 20374639 down-regulation -circulation_biomarker_diagnosis_down hsa-mir-181b-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 20393129 "miR-181b:We found that miR-15a, miR-21, miR-34a, miR-155, and miR-181b were differentially expressed between CLLs with chromosome 17p deletion and CLLs with normal 17p and normal karyotype, and that miR-181b was down-regulated in therapy-refractory cases" -circulation_biomarker_diagnosis_down hsa-mir-181b-2 "Leukemia, Lymphocytic, Chronic, B-Cell" 20393129 "miR-181b:We found that miR-15a, miR-21, miR-34a, miR-155, and miR-181b were differentially expressed between CLLs with chromosome 17p deletion and CLLs with normal 17p and normal karyotype, and that miR-181b was down-regulated in therapy-refractory cases" -circulation_biomarker_diagnosis_down hsa-let-7i Melanoma 20529253 let-7i*:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_down hsa-mir-106b Melanoma 20529253 miR-106b:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_down hsa-mir-107 Melanoma 20529253 miR-107:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_down hsa-mir-17 Melanoma 20529253 miR-17:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_down hsa-mir-20a Melanoma 20529253 miR-20a:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_down hsa-mir-20b Melanoma 20529253 miR-20b:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_down hsa-mir-214 Melanoma 20529253 miR-214:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_down hsa-mir-216a Melanoma 20529253 miR-216a:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_down hsa-mir-217 Melanoma 20529253 miR-217:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_down hsa-mir-221 Melanoma 20529253 miR-221*:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_down hsa-mir-330 Melanoma 20529253 miR-330-3p:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_down hsa-mir-452 Melanoma 20529253 miR-452:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_down hsa-mir-509-3 Melanoma 20529253 miR-509-3-5p:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_down hsa-mir-517a Melanoma 20529253 miR-517*:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_down hsa-mir-518e Melanoma 20529253 miR-518e*:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_down hsa-mir-519b Melanoma 20529253 miR-519b-5p:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_down hsa-mir-593 Melanoma 20529253 miR-593*:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_down hsa-mir-621 Melanoma 20529253 miR-621:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_down hsa-mir-646 Melanoma 20529253 miR-646:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_down hsa-mir-767 Melanoma 20529253 miR-767-5p:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_down hsa-mir-126 "Diabetes Mellitus, Type 2" 20651284 decreased in plasma -circulation_biomarker_diagnosis_down hsa-mir-15a "Diabetes Mellitus, Type 2" 20651284 decreased in plasma -circulation_biomarker_diagnosis_down hsa-mir-191 "Diabetes Mellitus, Type 2" 20651284 decreased in plasma -circulation_biomarker_diagnosis_down hsa-mir-197 "Diabetes Mellitus, Type 2" 20651284 decreased in plasma -circulation_biomarker_diagnosis_down hsa-mir-20b "Diabetes Mellitus, Type 2" 20651284 decreased in plasma -circulation_biomarker_diagnosis_down hsa-mir-21 "Diabetes Mellitus, Type 2" 20651284 decreased in plasma -circulation_biomarker_diagnosis_down hsa-mir-223 "Diabetes Mellitus, Type 2" 20651284 decreased in plasma -circulation_biomarker_diagnosis_down hsa-mir-24-1 "Diabetes Mellitus, Type 2" 20651284 decreased in plasma -circulation_biomarker_diagnosis_down hsa-mir-24-2 "Diabetes Mellitus, Type 2" 20651284 decreased in plasma -circulation_biomarker_diagnosis_down hsa-mir-320a "Diabetes Mellitus, Type 2" 20651284 decreased in plasma -circulation_biomarker_diagnosis_down hsa-mir-486 "Diabetes Mellitus, Type 2" 20651284 decreased in plasma -circulation_biomarker_diagnosis_down hsa-mir-101-1 "Lymphoma, Large-Cell, Anaplastic" 20805506 miR-101:miR-101 was down-regulated in all ALCL model systems -circulation_biomarker_diagnosis_down hsa-mir-101-2 "Lymphoma, Large-Cell, Anaplastic" 20805506 miR-101:miR-101 was down-regulated in all ALCL model systems -circulation_biomarker_diagnosis_down hsa-mir-181b-1 Autistic Disorder 20868653 miR-181b:deregulated -circulation_biomarker_diagnosis_down hsa-mir-486 Autistic Disorder 20868653 miR-486:deregulated -circulation_biomarker_diagnosis_down hsa-mir-27a Leukemia 21070600 Down-regulated miR-331-5p and miR-27a are associated with chemotherapy resistance and relapse in leukaemia. -circulation_biomarker_diagnosis_down hsa-mir-331 Leukemia 21070600 Down-regulated miR-331-5p and miR-27a are associated with chemotherapy resistance and relapse in leukaemia. -circulation_biomarker_diagnosis_down hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 21130495 Downregulation -circulation_biomarker_diagnosis_down hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 21130495 Downregulation -circulation_biomarker_diagnosis_down hsa-mir-181a-2 "Leukemia, Lymphocytic, Chronic, B-Cell" 21130495 Downregulation -circulation_biomarker_diagnosis_down hsa-mir-181b-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 21130495 Downregulation -circulation_biomarker_diagnosis_down hsa-mir-181b-2 "Leukemia, Lymphocytic, Chronic, B-Cell" 21130495 Downregulation -circulation_biomarker_diagnosis_down hsa-mir-29b-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 21130495 Downregulation -circulation_biomarker_diagnosis_down hsa-mir-29b-2 "Leukemia, Lymphocytic, Chronic, B-Cell" 21130495 Downregulation -circulation_biomarker_diagnosis_down hsa-let-7d Pancreatic Neoplasms 21139804 downregulated -circulation_biomarker_diagnosis_down hsa-mir-146a Pancreatic Neoplasms 21139804 downregulated -circulation_biomarker_diagnosis_down hsa-mir-126 Heart Failure 21157109 "The plasma concentration of miR-126 was negatively correlated with age and NYHA class, and could be a useful biomarker for heart failure" -circulation_biomarker_diagnosis_down hsa-mir-424 Hemangioma 21179471 Down-Regulation of mir-424 Contributes to the Abnormal Angiogenesis via MEK1 and Cyclin E1 in Senile Hemangioma: Its Implications to Therapy. -circulation_biomarker_diagnosis_down hsa-mir-503 Diabetes Mellitus 21220732 Deregulation of microRNA-503 Contributes to Diabetes Mellitus-Induced Impairment of Endothelial Function and Reparative Angiogenesis After Limb Ischemia. -circulation_biomarker_diagnosis_down hsa-mir-125b-1 Human Immunodeficiency Virus Infection 21224041 "heroin-dependent subjects had significantly lower levels of anti-HIV miRNAs (miRNA-28, 125b, 150, and 382) in peripheral blood mononuclear cells than the healthy subjects" -circulation_biomarker_diagnosis_down hsa-mir-125b-2 Human Immunodeficiency Virus Infection 21224041 "heroin-dependent subjects had significantly lower levels of anti-HIV miRNAs (miRNA-28, 125b, 150, and 382) in peripheral blood mononuclear cells than the healthy subjects" -circulation_biomarker_diagnosis_down hsa-mir-150 Human Immunodeficiency Virus Infection 21224041 "heroin-dependent subjects had significantly lower levels of anti-HIV miRNAs (miRNA-28, 125b, 150, and 382) in peripheral blood mononuclear cells than the healthy subjects" -circulation_biomarker_diagnosis_down hsa-mir-28 Human Immunodeficiency Virus Infection 21224041 "heroin-dependent subjects had significantly lower levels of anti-HIV miRNAs (miRNA-28, 125b, 150, and 382) in peripheral blood mononuclear cells than the healthy subjects" -circulation_biomarker_diagnosis_down hsa-mir-382 Human Immunodeficiency Virus Infection 21224041 "heroin-dependent subjects had significantly lower levels of anti-HIV miRNAs (miRNA-28, 125b, 150, and 382) in peripheral blood mononuclear cells than the healthy subjects" -circulation_biomarker_diagnosis_down hsa-let-7a-1 "Carcinoma, Renal Cell" 21229250 "let-7 family, miR-30c, miR-26a are decreased in highly aggressive primary metastatic tumours." -circulation_biomarker_diagnosis_down hsa-let-7a-2 "Carcinoma, Renal Cell" 21229250 "let-7 family, miR-30c, miR-26a are decreased in highly aggressive primary metastatic tumours." -circulation_biomarker_diagnosis_down hsa-let-7a-3 "Carcinoma, Renal Cell" 21229250 "let-7 family, miR-30c, miR-26a are decreased in highly aggressive primary metastatic tumours." -circulation_biomarker_diagnosis_down hsa-let-7b "Carcinoma, Renal Cell" 21229250 "let-7 family, miR-30c, miR-26a are decreased in highly aggressive primary metastatic tumours." -circulation_biomarker_diagnosis_down hsa-let-7c "Carcinoma, Renal Cell" 21229250 "let-7 family, miR-30c, miR-26a are decreased in highly aggressive primary metastatic tumours." -circulation_biomarker_diagnosis_down hsa-let-7d "Carcinoma, Renal Cell" 21229250 "let-7 family, miR-30c, miR-26a are decreased in highly aggressive primary metastatic tumours." -circulation_biomarker_diagnosis_down hsa-let-7e "Carcinoma, Renal Cell" 21229250 "let-7 family, miR-30c, miR-26a are decreased in highly aggressive primary metastatic tumours." -circulation_biomarker_diagnosis_down hsa-let-7f-1 "Carcinoma, Renal Cell" 21229250 "let-7 family, miR-30c, miR-26a are decreased in highly aggressive primary metastatic tumours." -circulation_biomarker_diagnosis_down hsa-let-7f-2 "Carcinoma, Renal Cell" 21229250 "let-7 family, miR-30c, miR-26a are decreased in highly aggressive primary metastatic tumours." -circulation_biomarker_diagnosis_down hsa-let-7g "Carcinoma, Renal Cell" 21229250 "let-7 family, miR-30c, miR-26a are decreased in highly aggressive primary metastatic tumours." -circulation_biomarker_diagnosis_down hsa-let-7i "Carcinoma, Renal Cell" 21229250 "let-7 family, miR-30c, miR-26a are decreased in highly aggressive primary metastatic tumours." -circulation_biomarker_diagnosis_down hsa-mir-26a-1 "Carcinoma, Renal Cell" 21229250 "let-7 family, miR-30c, miR-26a are decreased in highly aggressive primary metastatic tumours." -circulation_biomarker_diagnosis_down hsa-mir-26a-2 "Carcinoma, Renal Cell" 21229250 "let-7 family, miR-30c, miR-26a are decreased in highly aggressive primary metastatic tumours." -circulation_biomarker_diagnosis_down hsa-mir-30c-1 "Carcinoma, Renal Cell" 21229250 "let-7 family, miR-30c, miR-26a are decreased in highly aggressive primary metastatic tumours." -circulation_biomarker_diagnosis_down hsa-mir-30c-2 "Carcinoma, Renal Cell" 21229250 "let-7 family, miR-30c, miR-26a are decreased in highly aggressive primary metastatic tumours." -circulation_biomarker_diagnosis_down hsa-let-7b "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 21242186 "aberrant downregulation of let-7b (~70-fold) in MLL-rearranged acute lymphoblastic leukemia was linked to upregulation of oncoprotein c-Myc (P<0.0001). Resistance to vincristine and daunorubicin was characterized by ~20-fold upregulation of miR-125b, miR-99a and miR-100 (P<0.002)." -circulation_biomarker_diagnosis_down hsa-mir-16-1 "Carcinoma, Hepatocellular" 21278583 Serum levels of miR-16 and miR-199a were significantly lower in HCC than in CLD patients or control subjects (P<0.01). -circulation_biomarker_diagnosis_down hsa-mir-16-2 "Carcinoma, Hepatocellular" 21278583 Serum levels of miR-16 and miR-199a were significantly lower in HCC than in CLD patients or control subjects (P<0.01). -circulation_biomarker_diagnosis_down hsa-mir-199a-1 "Carcinoma, Hepatocellular" 21278583 Serum levels of miR-16 and miR-199a were significantly lower in HCC than in CLD patients or control subjects (P<0.01). -circulation_biomarker_diagnosis_down hsa-mir-199a-2 "Carcinoma, Hepatocellular" 21278583 Serum levels of miR-16 and miR-199a were significantly lower in HCC than in CLD patients or control subjects (P<0.01). -circulation_biomarker_diagnosis_down hsa-mir-1-1 Hypertrophy 21303526 "The downregulation of miR-1, miR-133a, and upregulation of miR-21 can be reversed by one single upstream regulator, SRF." -circulation_biomarker_diagnosis_down hsa-mir-1-2 Hypertrophy 21303526 "The downregulation of miR-1, miR-133a, and upregulation of miR-21 can be reversed by one single upstream regulator, SRF." -circulation_biomarker_diagnosis_down hsa-mir-133a-1 Hypertrophy 21303526 "The downregulation of miR-1, miR-133a, and upregulation of miR-21 can be reversed by one single upstream regulator, SRF." -circulation_biomarker_diagnosis_down hsa-mir-133a-2 Hypertrophy 21303526 "The downregulation of miR-1, miR-133a, and upregulation of miR-21 can be reversed by one single upstream regulator, SRF." -circulation_biomarker_diagnosis_down hsa-mir-101-1 Glioblastoma 21321380 "miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis." -circulation_biomarker_diagnosis_down hsa-mir-101-2 Glioblastoma 21321380 "miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis." -circulation_biomarker_diagnosis_down hsa-mir-141 Systemic Lupus Erythematosus 21372198 "The serum levels of miR-200a, miR-200b, miR-200c, miR-429, miR-205 and miR-192, and urinary miR-200a, miR-200c, miR-141, miR-429 and miR-192 of SLE patients were lower than those of controls." -circulation_biomarker_diagnosis_down hsa-mir-192 Systemic Lupus Erythematosus 21372198 "The serum levels of miR-200a, miR-200b, miR-200c, miR-429, miR-205 and miR-192, and urinary miR-200a, miR-200c, miR-141, miR-429 and miR-192 of SLE patients were lower than those of controls." -circulation_biomarker_diagnosis_down hsa-mir-200a Systemic Lupus Erythematosus 21372198 "The serum levels of miR-200a, miR-200b, miR-200c, miR-429, miR-205 and miR-192, and urinary miR-200a, miR-200c, miR-141, miR-429 and miR-192 of SLE patients were lower than those of controls." -circulation_biomarker_diagnosis_down hsa-mir-200b Systemic Lupus Erythematosus 21372198 "The serum levels of miR-200a, miR-200b, miR-200c, miR-429, miR-205 and miR-192, and urinary miR-200a, miR-200c, miR-141, miR-429 and miR-192 of SLE patients were lower than those of controls." -circulation_biomarker_diagnosis_down hsa-mir-200c Systemic Lupus Erythematosus 21372198 "The serum levels of miR-200a, miR-200b, miR-200c, miR-429, miR-205 and miR-192, and urinary miR-200a, miR-200c, miR-141, miR-429 and miR-192 of SLE patients were lower than those of controls." -circulation_biomarker_diagnosis_down hsa-mir-205 Systemic Lupus Erythematosus 21372198 "The serum levels of miR-200a, miR-200b, miR-200c, miR-429, miR-205 and miR-192, and urinary miR-200a, miR-200c, miR-141, miR-429 and miR-192 of SLE patients were lower than those of controls." -circulation_biomarker_diagnosis_down hsa-mir-429 Systemic Lupus Erythematosus 21372198 "The serum levels of miR-200a, miR-200b, miR-200c, miR-429, miR-205 and miR-192, and urinary miR-200a, miR-200c, miR-141, miR-429 and miR-192 of SLE patients were lower than those of controls." -circulation_biomarker_diagnosis_down hsa-mir-92a-1 Lymphoma 21383985 Down-Regulated Plasma miR-92a Levels in Non-Hodgkin's Lymphoma. -circulation_biomarker_diagnosis_down hsa-mir-92a-2 Lymphoma 21383985 Down-Regulated Plasma miR-92a Levels in Non-Hodgkin's Lymphoma. -circulation_biomarker_diagnosis_down hsa-mir-103a-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 21408091 downregulation -circulation_biomarker_diagnosis_down hsa-mir-103a-2 "Leukemia, Lymphocytic, Chronic, B-Cell" 21408091 downregulation -circulation_biomarker_diagnosis_down hsa-mir-181a-2 "Leukemia, Lymphocytic, Chronic, B-Cell" 21408091 downregulation -circulation_biomarker_diagnosis_down hsa-mir-181b-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 21408091 downregulation -circulation_biomarker_diagnosis_down hsa-mir-181b-2 "Leukemia, Lymphocytic, Chronic, B-Cell" 21408091 downregulation -circulation_biomarker_diagnosis_down hsa-mir-16-1 "Leukemia-Lymphoma, Adult T-Cell" 21441948 Triptolide inhibits the proliferation of cells from lymphocytic leukemic cell lines in association with downregulation of NF-kB activity and miR-16-1(*). -circulation_biomarker_diagnosis_down hsa-mir-100 "Carcinoma, Adrenocortical" 21472710 "miRs -100, -125b, and -195 were significantly down-regulated, whereas miR-483-5p was significantly up-regulated in malignant as compared with benign tumors." -circulation_biomarker_diagnosis_down hsa-mir-126 Mesothelioma 21483773 "Levels of miR-126 in serum, and its levels in patients' serum in association with a specific marker of MPM, SMRPs, correlate with subjects at high risk to develop malignant pleural mesothelioma (MPM)." -circulation_biomarker_diagnosis_down hsa-mir-451a "Leukemia, Myeloid, Chronic" 21511335 downregulated -circulation_biomarker_diagnosis_down hsa-mir-106a "Carcinoma, Lung, Non-Small-Cell" 21544802 "The expression of miR-146b, miR-221, let-7a, miR-155, miR-17-5p, miR-27a and miR-106a were significantly reduced in the serum of NSCLC cases while miR-29c was significantly increased." -circulation_biomarker_diagnosis_down hsa-mir-146b "Carcinoma, Lung, Non-Small-Cell" 21544802 "The expression of miR-146b, miR-221, let-7a, miR-155, miR-17-5p, miR-27a and miR-106a were significantly reduced in the serum of NSCLC cases while miR-29c was significantly increased." -circulation_biomarker_diagnosis_down hsa-mir-155 "Carcinoma, Lung, Non-Small-Cell" 21544802 "The expression of miR-146b, miR-221, let-7a, miR-155, miR-17-5p, miR-27a and miR-106a were significantly reduced in the serum of NSCLC cases while miR-29c was significantly increased." -circulation_biomarker_diagnosis_down hsa-mir-17 "Carcinoma, Lung, Non-Small-Cell" 21544802 "The expression of miR-146b, miR-221, let-7a, miR-155, miR-17-5p, miR-27a and miR-106a were significantly reduced in the serum of NSCLC cases while miR-29c was significantly increased." -circulation_biomarker_diagnosis_down hsa-mir-221 "Carcinoma, Lung, Non-Small-Cell" 21544802 "The expression of miR-146b, miR-221, let-7a, miR-155, miR-17-5p, miR-27a and miR-106a were significantly reduced in the serum of NSCLC cases while miR-29c was significantly increased." -circulation_biomarker_diagnosis_down hsa-mir-223 "Carcinoma, Lung, Non-Small-Cell" 21544802 Reduced plasma expression of let-7b was modestly associated with worse cancer-specific mortality in all patients and reduced serum expression of miR-223 was modestly associated with cancer-specific mortality in stage IA/B patients. -circulation_biomarker_diagnosis_down hsa-mir-27a "Carcinoma, Lung, Non-Small-Cell" 21544802 "The expression of miR-146b, miR-221, let-7a, miR-155, miR-17-5p, miR-27a and miR-106a were significantly reduced in the serum of NSCLC cases while miR-29c was significantly increased." -circulation_biomarker_diagnosis_down hsa-mir-590 Alzheimer Disease 21548758 "Decreased relative expression levels of hsa-miR-590-3p in blood cells was observed in patients with AD versus controls. hnRNP-A1 and its transcription regulatory factor miR-590-3p are disregulated in patients with AD, and the hnRNP-A1 rs7967622 C/C genotype is likely a risk factor for FTLD in male populations." -circulation_biomarker_diagnosis_down hsa-mir-342 Glioblastoma 21561454 miR-342-3p: downregulated in the peripheral blood of glioblastoma patients. -circulation_biomarker_diagnosis_down hsa-mir-181b-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 21636858 MiR-181b is a biomarker of disease progression in chronic lymphocytic leukemia -circulation_biomarker_diagnosis_down hsa-mir-181b-2 "Leukemia, Lymphocytic, Chronic, B-Cell" 21636858 MiR-181b is a biomarker of disease progression in chronic lymphocytic leukemia -circulation_biomarker_diagnosis_down hsa-mir-671 Myelodysplastic Syndromes 21649547 miR-671-5p: down-regulation -circulation_biomarker_diagnosis_down hsa-mir-375 "Squamous Cell Carcinoma, Esophageal" 21673684 "the plasma level of miR-21 was significantly higher (P=0.0218) and that of miR-375 (P=0.0052) was significantly lower in ESCC patients than controls. (2) The high plasma miR-21 levels reflected tumour levels in all cases (100%). The plasma level of miR-21 was significantly reduced in postoperative samples (P=0.0058). (3) On validation analysis, the plasma level of miR-21 tended to be higher in ESCC patients (P=0.0649), while that of miR-375 was significantly lower (P<0.0001) and the miR-21/miR-375 ratio was significantly higher (P<0.0001) in ESCC patients than in controls. The value of the area under the receiver-operating characteristic curve (AUC) was 0.816 for the miR-21/miR-375 ratio assay. Patients with a high plasma level of miR-21 tended to have greater vascular invasion (P=0.1554) and to show a high correlation with recurrence (P=0.0164)." -circulation_biomarker_diagnosis_down hsa-mir-143 "Leukemia, Myeloid, Acute" 21678057 miR-29a and miR-142-3p show downregulation and diagnostic implication in human acute myeloid leukemia. -circulation_biomarker_diagnosis_down hsa-mir-29a "Leukemia, Myeloid, Acute" 21678057 miR-29a and miR-142-3p show downregulation and diagnostic implication in human acute myeloid leukemia. -circulation_biomarker_diagnosis_down hsa-mir-21 "Carcinoma, Hepatocellular" 21749846 "In the 10-patient group, plasma microRNA-21 levels significantly diminished after surgery compared with the pre-operative values (p=0.0125). Plasma microRNA-21 level in the 126 patients with hepatocellular carcinoma was significantly higher than in patients with chronic hepatitis and healthy volunteers (p<0.0001, p<0.0001, respectively). ROC analysis of plasma microRNA-21 yielded an AUC of 0.773 with 61.1% sensitivity and 83.3% specificity when differentiating hepatocellular carcinoma from chronic hepatitis, and an AUC of 0.953 with 87.3% sensitivity and 92.0% specificity when differentiating hepatocellular carcinoma from healthy volunteers." -circulation_biomarker_diagnosis_down hsa-mir-29a "Leukemia, Myeloid, Acute" 21818844 "Lower miR-29a expression was mainly observed in MLL-rearranged pediatric acute myeloid leukemia, specifically in cases carrying t(10;11)." -circulation_biomarker_diagnosis_down hsa-mir-17 Lymphoma 21910161 "miR-17-5p: Compared with normal canine peripheral blood mononuclear cells (PBMC) and normal lymph nodes (LN), the miRNA show an increased expression level." -circulation_biomarker_diagnosis_down hsa-mir-181a-2 Lymphoma 21910161 "Compared with normal canine peripheral blood mononuclear cells (PBMC) and normal lymph nodes (LN), the miRNA show a decreased expression level." -circulation_biomarker_diagnosis_down hsa-mir-19a Lymphoma 21910161 "Compared with normal canine peripheral blood mononuclear cells (PBMC) and normal lymph nodes (LN), the miRNA show an increased expression level." -circulation_biomarker_diagnosis_down hsa-mir-19b-1 Lymphoma 21910161 "Compared with normal canine peripheral blood mononuclear cells (PBMC) and normal lymph nodes (LN), the miRNA show an increased expression level." -circulation_biomarker_diagnosis_down hsa-mir-19b-2 Lymphoma 21910161 "Compared with normal cani ne peripheral blood mononuclear cells (PBMC) and normal lymph nodes (LN), the miRNA show an increased expression level." -circulation_biomarker_diagnosis_down hsa-mir-203 Lymphoma 21910161 "Compared with normal canine peripheral blood mononuclear cells (PBMC) and normal lymph nodes (LN), the miRNA show a decreased expression level." -circulation_biomarker_diagnosis_down hsa-mir-218-1 Lymphoma 21910161 "Compared with normal canine peripheral blood mononuclear cells (PBMC) and normal lymph nodes (LN), the miRNA show a decreased expression level." -circulation_biomarker_diagnosis_down hsa-mir-218-2 Lymphoma 21910161 "Compared with normal canine peripheral blood mononuclear cells (PBMC) and normal lymph nodes (LN), the miRNA show a decreased expression level." -circulation_biomarker_diagnosis_down hsa-mir-133b Hypertension 21924071 "MiR-296-5p (Fold change 0.47, P = 0.013) and miR-133b (Fold change 0.57, P = 0.033) were consistently down-regulated in the patient plasma, whereas let-7e (Fold change 1.62, P = 0.009) and hcmv-miR-UL112 (Fold change 2.72, P = 0.004), one human cytomegalovirus encoded microRNAs, were up-regulated in the patient samples." -circulation_biomarker_diagnosis_down hsa-mir-296 Hypertension 21924071 "MiR-296-5p (Fold change 0.47, P = 0.013) and miR-133b (Fold change 0.57, P = 0.033) were consistently down-regulated in the patient plasma, whereas let-7e (Fold change 1.62, P = 0.009) and hcmv-miR-UL112 (Fold change 2.72, P = 0.004), one human cytomegalovirus encoded microRNAs, were up-regulated in the patient samples." -circulation_biomarker_diagnosis_down hsa-mir-152 Preeclampsia 22095477 Serum expression level of mir-152 was down-regulated in preeclampsia patients. -circulation_biomarker_diagnosis_down hsa-mir-218-1 Urinary Bladder Cancer 22237456 Circulating microRNA-218 was reduced in cervical cancer and correlated with tumor invasion. -circulation_biomarker_diagnosis_down hsa-mir-218-2 Urinary Bladder Cancer 22237456 Circulating microRNA-218 was reduced in cervical cancer and correlated with tumor invasion. -circulation_biomarker_diagnosis_down hsa-mir-107 Breast Neoplasms 22242178 The miRNA is down-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_down hsa-mir-1469 Breast Neoplasms 22242178 The miRNA is down-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_down hsa-mir-1471 Breast Neoplasms 22242178 The miRNA is down-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_down hsa-mir-182 Breast Neoplasms 22242178 The miRNA is down-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_down hsa-mir-1915 Breast Neoplasms 22242178 The miRNA is down-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_down hsa-mir-193a Breast Neoplasms 22242178 miR-193a-3p is down-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_down hsa-mir-2355 Breast Neoplasms 22242178 The miRNA is down-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_down hsa-mir-24-1 Breast Neoplasms 22242178 The miRNA is down-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_down hsa-mir-24-2 Breast Neoplasms 22242178 The miRNA is down-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_down hsa-mir-3130-1 Breast Neoplasms 22242178 The miRNA is down-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_down hsa-mir-3130-2 Breast Neoplasms 22242178 The miRNA is down-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_down hsa-mir-3186 Breast Neoplasms 22242178 The miRNA is down-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_down hsa-mir-526a-1 Breast Neoplasms 22242178 The miRNA is down-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_down hsa-mir-526a-2 Breast Neoplasms 22242178 The miRNA is down-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_down hsa-mir-625 Breast Neoplasms 22242178 miR-625* is down-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_down hsa-mir-718 Breast Neoplasms 22242178 The miRNA is down-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_down hsa-mir-874 Breast Neoplasms 22242178 The miRNA is down-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_down hsa-mir-181a-2 "Leukemia, Myeloid, Acute" 22251480 Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML. -circulation_biomarker_diagnosis_down hsa-mir-181b-1 "Leukemia, Myeloid, Acute" 22251480 Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML. -circulation_biomarker_diagnosis_down hsa-mir-181b-2 "Leukemia, Myeloid, Acute" 22251480 Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML. -circulation_biomarker_diagnosis_down hsa-mir-181c "Leukemia, Myeloid, Acute" 22251480 Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML. -circulation_biomarker_diagnosis_down hsa-mir-181d "Leukemia, Myeloid, Acute" 22251480 Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML. -circulation_biomarker_diagnosis_down hsa-mir-508 "Carcinoma, Renal Cell" 22369946 "Both miR-508-3p and miR-509-3p were down-regulated in renal cancer tissues. The level of miR-508-3p but not miR-509-3p in renal cell carcinoma (RCC) patient plasma demonstrated significant differences from that in control plasma. In addition, the overexpression of miR-508-3p and miR-509-3p suppressed the proliferation of RCC cells (786-0), induced cell apoptosis and inhibited cell migration in vitro." -circulation_biomarker_diagnosis_down hsa-mir-509-1 "Carcinoma, Renal Cell" 22369946 "Both miR-508-3p and miR-509-3p were down-regulated in renal cancer tissues. The level of miR-508-3p but not miR-509-3p in renal cell carcinoma (RCC) patient plasma demonstrated significant differences from that in control plasma. In addition, the overexpression of miR-508-3p and miR-509-3p suppressed the proliferation of RCC cells (786-0), induced cell apoptosis and inhibited cell migration in vitro." -circulation_biomarker_diagnosis_down hsa-mir-509-2 "Carcinoma, Renal Cell" 22369946 "Both miR-508-3p and miR-509-3p were down-regulated in renal cancer tissues. The level of miR-508-3p but not miR-509-3p in renal cell carcinoma (RCC) patient plasma demonstrated significant differences from that in control plasma. In addition, the overexpression of miR-508-3p and miR-509-3p suppressed the proliferation of RCC cells (786-0), induced cell apoptosis and inhibited cell migration in vitro." -circulation_biomarker_diagnosis_down hsa-mir-509-3 "Carcinoma, Renal Cell" 22369946 "Both miR-508-3p and miR-509-3p were down-regulated in renal cancer tissues. The level of miR-508-3p but not miR-509-3p in renal cell carcinoma (RCC) patient plasma demonstrated significant differences from that in control plasma. In addition, the overexpression of miR-508-3p and miR-509-3p suppressed the proliferation of RCC cells (786-0), induced cell apoptosis and inhibited cell migration in vitro." -circulation_biomarker_diagnosis_down hsa-mir-126 Mesothelioma 22374169 Kaplan-Meier analysis revealed that low level of circulating miR-126 in MM patients was strongly associated with worse prognosis. -circulation_biomarker_diagnosis_down hsa-let-7c Eosinophilic Esophagitis 22391115 downregulated -circulation_biomarker_diagnosis_down hsa-mir-144 Eosinophilic Esophagitis 22391115 miR-144*: downregulated -circulation_biomarker_diagnosis_down hsa-mir-193a Eosinophilic Esophagitis 22391115 miR-193a-5p and miR-193a-3p: downregulated -circulation_biomarker_diagnosis_down hsa-mir-193b Eosinophilic Esophagitis 22391115 downregulated -circulation_biomarker_diagnosis_down hsa-mir-203 Eosinophilic Esophagitis 22391115 downregulated -circulation_biomarker_diagnosis_down hsa-mir-210 Eosinophilic Esophagitis 22391115 downregulated -circulation_biomarker_diagnosis_down hsa-mir-211 Eosinophilic Esophagitis 22391115 downregulated -circulation_biomarker_diagnosis_down hsa-mir-30a Eosinophilic Esophagitis 22391115 miR-30a-3p: downregulated -circulation_biomarker_diagnosis_down hsa-mir-365a Eosinophilic Esophagitis 22391115 downregulated -circulation_biomarker_diagnosis_down hsa-mir-375 Eosinophilic Esophagitis 22391115 "The most downregulated miRNA, which strongly correlated with esophageal eosinophil levels." -circulation_biomarker_diagnosis_down hsa-mir-517a Ectopic Pregnancy 22395025 "Concentrations of serum hCG, progesterone, miR-517a, miR-519d, and miR-525-3p were significantly lower in EP and SA cases than in VIP cases. In contrast, the concentration of miR-323-3p was significantly increased in EP cases, compared with SA and VIP cases. As a single marker, miR-323-3p had the highest sensitivity of 37.0% (at a fixed specificity of 90%)." -circulation_biomarker_diagnosis_down hsa-mir-519d Ectopic Pregnancy 22395025 "Concentrations of serum hCG, progesterone, miR-517a, miR-519d, and miR-525-3p were significantly lower in EP and SA cases than in VIP cases. In contrast, the concentration of miR-323-3p was significantly increased in EP cases, compared with SA and VIP cases. As a single marker, miR-323-3p had the highest sensitivity of 37.0% (at a fixed specificity of 90%)." -circulation_biomarker_diagnosis_down hsa-mir-525 Ectopic Pregnancy 22395025 "Concentrations of serum hCG, progesterone, miR-517a, miR-519d, and miR-525-3p were significantly lower in EP and SA cases than in VIP cases. In contrast, the concentration of miR-323-3p was significantly increased in EP cases, compared with SA and VIP cases. As a single marker, miR-323-3p had the highest sensitivity of 37.0% (at a fixed specificity of 90%)." -circulation_biomarker_diagnosis_down hsa-let-7a-1 "Carcinoma, Renal Cell" 22440013 Down-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_down hsa-let-7a-2 "Carcinoma, Renal Cell" 22440013 Down-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_down hsa-let-7a-3 "Carcinoma, Renal Cell" 22440013 Down-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_down hsa-let-7f-1 "Carcinoma, Renal Cell" 22440013 Down-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_down hsa-let-7f-2 "Carcinoma, Renal Cell" 22440013 Down-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_down hsa-mir-142 "Carcinoma, Renal Cell" 22440013 miR-142-5p: Down-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_down hsa-mir-150 "Carcinoma, Renal Cell" 22440013 Down-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_down hsa-mir-19a "Carcinoma, Renal Cell" 22440013 Down-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_down hsa-mir-219 "Carcinoma, Renal Cell" 22440013 miR-219-5p: Down-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_down hsa-mir-302b "Carcinoma, Renal Cell" 22440013 Down-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_down hsa-mir-302c "Carcinoma, Renal Cell" 22440013 Down-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_down hsa-mir-367 "Carcinoma, Renal Cell" 22440013 Down-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_down hsa-mir-381 "Carcinoma, Renal Cell" 22440013 Down-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_down hsa-mir-451a "Carcinoma, Renal Cell" 22440013 Down-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_down hsa-mir-154 Graves Disease 22456620 "The expression of miR-154*, miR-376b, and miR-431* were suppressed in PBMC (peripheral blood mononuclear cells) from initial GD patients. In addition, their expression levels were recovered in GD patients in remission." -circulation_biomarker_diagnosis_down hsa-mir-376b Graves Disease 22456620 "The expression of miR-154*, miR-376b, and miR-431* were suppressed in PBMC (peripheral blood mononuclear cells) from initial GD patients. In addition, their expression levels were recovered in GD patients in remission." -circulation_biomarker_diagnosis_down hsa-mir-431 Graves Disease 22456620 "The expression of miR-154*, miR-376b, and miR-431* were suppressed in PBMC (peripheral blood mononuclear cells) from initial GD patients. In addition, their expression levels were recovered in GD patients in remission." -circulation_biomarker_diagnosis_down hsa-mir-34a Colorectal Carcinoma 22648208 Circulating miR-34a levels are reduced in colorectal cancer. -circulation_biomarker_diagnosis_down hsa-mir-361 "Carcinoma, Lung, Non-Small-Cell" 22675530 Low levels of cell-free circulating miR-361-3p and miR-625* could be blood-based markers for discriminating malignant from benign lung tumors. -circulation_biomarker_diagnosis_down hsa-mir-625 "Carcinoma, Lung, Non-Small-Cell" 22675530 Low levels of cell-free circulating miR-361-3p and miR-625* could be blood-based markers for discriminating malignant from benign lung tumors. -circulation_biomarker_diagnosis_down hsa-mir-181a-2 Breast Neoplasms 22692639 Decreased serum miR-181a is a potential new tool for breast cancer screening. -circulation_biomarker_diagnosis_down hsa-let-7b Prostate Neoplasms 22719071 downregulated in prostate cancer stem/progenitor cell. -circulation_biomarker_diagnosis_down hsa-mir-126 Myocardial Infarction 22719221 Increased miR-1 and decreased miR-126 in plasma from patients with AMI after the onset of symptoms compared with healthy subjects were found. -circulation_biomarker_diagnosis_down hsa-mir-21 Lung Neoplasms 22782668 "In addition, miR-21 and miR-24 serum levels were lower in post-operative samples than those in pre-operative samples, suggesting they can potentially be used as biomarkers for disease recurrence after surgery operation." -circulation_biomarker_diagnosis_down hsa-mir-24 Lung Neoplasms 22782668 "In addition, miR-21 and miR-24 serum levels were lower in post-operative samples than those in pre-operative samples, suggesting they can potentially be used as biomarkers for disease recurrence after surgery operation." -circulation_biomarker_diagnosis_down hsa-mir-92a-1 Multiple Myeloma 22829237 Downregulated plasma miR-92a levels have clinical impact on multiple myeloma and related disorders. -circulation_biomarker_diagnosis_down hsa-mir-155 Hepatitis C Virus Infection 22846613 Increased microRNA-155 expression in the serum and peripheral monocytes in chronic HCV infection. -circulation_biomarker_diagnosis_down hsa-mir-218-1 Gastric Neoplasms 22860003 "The plasma levels of miR-223 (P<0.001) and miR-21 (P<0.001) were significantly higher in GC patients than in healthy controls, while miR-218 (P<0.001) was significantly lower. The ROC analyses yielded the AUC values of 0.9089 for miR-223, 0.7944 for miR-21 and 0.7432 for miR-218, and combined ROC analysis revealed the highest AUC value of 0.9531 in discriminating GC patients from healthy controls." -circulation_biomarker_diagnosis_down hsa-mir-218-2 Gastric Neoplasms 22860003 "The plasma levels of miR-223 (P<0.001) and miR-21 (P<0.001) were significantly higher in GC patients than in healthy controls, while miR-218 (P<0.001) was significantly lower. The ROC analyses yielded the AUC values of 0.9089 for miR-223, 0.7944 for miR-21 and 0.7432 for miR-218, and combined ROC analysis revealed the highest AUC value of 0.9531 in discriminating GC patients from healthy controls." -circulation_biomarker_diagnosis_down hsa-let-7c Lung Neoplasms 22862169 "Some miRNAs as hsa-miR-126, hsa-miR-145, hsa-let-7g, hsa-let-7d, hsa-let-7c, hsa-let-7e and hsa-miR-98, which were lowly expressed in SPC-A1 cells, were not expressed in the pulmospheres." -circulation_biomarker_diagnosis_down hsa-let-7d Lung Neoplasms 22862169 "Some miRNAs as hsa-miR-126, hsa-miR-145, hsa-let-7g, hsa-let-7d, hsa-let-7c, hsa-let-7e and hsa-miR-98, which were lowly expressed in SPC-A1 cells, were not expressed in the pulmospheres." -circulation_biomarker_diagnosis_down hsa-let-7e Lung Neoplasms 22862169 "Some miRNAs as hsa-miR-126, hsa-miR-145, hsa-let-7g, hsa-let-7d, hsa-let-7c, hsa-let-7e and hsa-miR-98, which were lowly expressed in SPC-A1 cells, were not expressed in the pulmospheres." -circulation_biomarker_diagnosis_down hsa-let-7g Lung Neoplasms 22862169 "Some miRNAs as hsa-miR-126, hsa-miR-145, hsa-let-7g, hsa-let-7d, hsa-let-7c, hsa-let-7e and hsa-miR-98, which were lowly expressed in SPC-A1 cells, were not expressed in the pulmospheres." -circulation_biomarker_diagnosis_down hsa-mir-126 Lung Neoplasms 22862169 "Some miRNAs as hsa-miR-126, hsa-miR-145, hsa-let-7g, hsa-let-7d, hsa-let-7c, hsa-let-7e and hsa-miR-98, which were lowly expressed in SPC-A1 cells, were not expressed in the pulmospheres." -circulation_biomarker_diagnosis_down hsa-mir-145 Lung Neoplasms 22862169 "Some miRNAs as hsa-miR-126, hsa-miR-145, hsa-let-7g, hsa-let-7d, hsa-let-7c, hsa-let-7e and hsa-miR-98, which were lowly expressed in SPC-A1 cells, were not expressed in the pulmospheres." -circulation_biomarker_diagnosis_down hsa-mir-98 Lung Neoplasms 22862169 "Some miRNAs as hsa-miR-126, hsa-miR-145, hsa-let-7g, hsa-let-7d, hsa-let-7c, hsa-let-7e and hsa-miR-98, which were lowly expressed in SPC-A1 cells, were not expressed in the pulmospheres." -circulation_biomarker_diagnosis_down hsa-mir-409 Prostate Neoplasms 22887127 "MiR-375, miR-378*, and miR-141 were significantly over-expressed in serum from CRPC patients compared with serum from low-risk localized patients, while miR-409-3p was significantly under-expressed. In prostate primary tumor samples, miR-375 and miR-141 also had significantly higher expression levels compared with those in normal prostate tissue." -circulation_biomarker_diagnosis_down hsa-mir-125b Prostate Neoplasms 22892455 An increase in serum miR-223 and a decrease in miR-125b and miR-146a were observed in group B. -circulation_biomarker_diagnosis_down hsa-mir-146a Prostate Neoplasms 22892455 An increase in serum miR-223 and a decrease in miR-125b and miR-146a were observed in group B. -circulation_biomarker_diagnosis_down hsa-mir-421 Gastric Neoplasms 22926798 Gastric juice microRNA-421 is a new biomarker for screening gastric cancer. -circulation_biomarker_diagnosis_down hsa-mir-29a "Leukemia, Myeloid, Acute" 22981932 "Our data indicate for the first time that the down-regulation of miR-29a was associated with advanced clinical features and poor prognosis of pediatric AML patients, suggesting that miR-29a down-regulation may be used as an unfavorable prognostic marker in pediatric AML." -circulation_biomarker_diagnosis_down hsa-mir-21 Breast Neoplasms 23052693 Circulating microRNA-92a and microRNA-21 as novel minimally invasive biomarkers for primary breast cancer -circulation_biomarker_diagnosis_down hsa-mir-92a-1 Breast Neoplasms 23052693 Circulating microRNA-92a and microRNA-21 as novel minimally invasive biomarkers for primary breast cancer -circulation_biomarker_diagnosis_down hsa-mir-92a-2 Breast Neoplasms 23052693 Circulating microRNA-92a and microRNA-21 as novel minimally invasive biomarkers for primary breast cancer -circulation_biomarker_diagnosis_down hsa-mir-17 Systemic Lupus Erythematosus 23129428 Dual downregulation of microRNA 17-5p and E2F1 transcriptional factor in pediatric systemic lupus erythematosus patients -circulation_biomarker_diagnosis_down hsa-mir-145 Systemic Lupus Erythematosus 23199328 Decreased microRNA(miR)-145 and increased miR-224 expression in T cells from patients with systemic lupus erythematosus involved in lupus immunopathogenesis -circulation_biomarker_diagnosis_down hsa-mir-17 Endometriosis 23203215 "Plasma miR-17-5p, miR-20a and miR-22 are down-regulated in women with endometriosis" -circulation_biomarker_diagnosis_down hsa-mir-20a Endometriosis 23203215 "Plasma miR-17-5p, miR-20a and miR-22 are down-regulated in women with endometriosis" -circulation_biomarker_diagnosis_down hsa-mir-22 Endometriosis 23203215 "Plasma miR-17-5p, miR-20a and miR-22 are down-regulated in women with endometriosis" -circulation_biomarker_diagnosis_down hsa-mir-146b "Leukemia, Lymphocytic, Chronic, B-Cell" 23286334 "we found that malignant B-cells from patients with CLL subsequently developing AIHA present nine down-regulated (i.e. miR-19a, miR-20a, miR-29c, miR-146b-5p, miR-186, miR-223, miR-324-3p, miR-484 and miR-660) miRNAs." -circulation_biomarker_diagnosis_down hsa-mir-186 "Leukemia, Lymphocytic, Chronic, B-Cell" 23286334 "we found that malignant B-cells from patients with CLL subsequently developing AIHA present nine down-regulated (i.e. miR-19a, miR-20a, miR-29c, miR-146b-5p, miR-186, miR-223, miR-324-3p, miR-484 and miR-660) miRNAs." -circulation_biomarker_diagnosis_down hsa-mir-19a "Leukemia, Lymphocytic, Chronic, B-Cell" 23286334 "we found that malignant B-cells from patients with CLL subsequently developing AIHA present nine down-regulated (i.e. miR-19a, miR-20a, miR-29c, miR-146b-5p, miR-186, miR-223, miR-324-3p, miR-484 and miR-660) miRNAs." -circulation_biomarker_diagnosis_down hsa-mir-20a "Leukemia, Lymphocytic, Chronic, B-Cell" 23286334 "we found that malignant B-cells from patients with CLL subsequently developing AIHA present nine down-regulated (i.e. miR-19a, miR-20a, miR-29c, miR-146b-5p, miR-186, miR-223, miR-324-3p, miR-484 and miR-660) miRNAs." -circulation_biomarker_diagnosis_down hsa-mir-223 "Leukemia, Lymphocytic, Chronic, B-Cell" 23286334 "we found that malignant B-cells from patients with CLL subsequently developing AIHA present nine down-regulated (i.e. miR-19a, miR-20a, miR-29c, miR-146b-5p, miR-186, miR-223, miR-324-3p, miR-484 and miR-660) miRNAs." -circulation_biomarker_diagnosis_down hsa-mir-29c "Leukemia, Lymphocytic, Chronic, B-Cell" 23286334 "we found that malignant B-cells from patients with CLL subsequently developing AIHA present nine down-regulated (i.e. miR-19a, miR-20a, miR-29c, miR-146b-5p, miR-186, miR-223, miR-324-3p, miR-484 and miR-660) miRNAs." -circulation_biomarker_diagnosis_down hsa-mir-324 "Leukemia, Lymphocytic, Chronic, B-Cell" 23286334 "we found that malignant B-cells from patients with CLL subsequently developing AIHA present nine down-regulated (i.e. miR-19a, miR-20a, miR-29c, miR-146b-5p, miR-186, miR-223, miR-324-3p, miR-484 and miR-660) miRNAs." -circulation_biomarker_diagnosis_down hsa-mir-484 "Leukemia, Lymphocytic, Chronic, B-Cell" 23286334 "we found that malignant B-cells from patients with CLL subsequently developing AIHA present nine down-regulated (i.e. miR-19a, miR-20a, miR-29c, miR-146b-5p, miR-186, miR-223, miR-324-3p, miR-484 and miR-660) miRNAs." -circulation_biomarker_diagnosis_down hsa-mir-660 "Leukemia, Lymphocytic, Chronic, B-Cell" 23286334 "we found that malignant B-cells from patients with CLL subsequently developing AIHA present nine down-regulated (i.e. miR-19a, miR-20a, miR-29c, miR-146b-5p, miR-186, miR-223, miR-324-3p, miR-484 and miR-660) miRNAs." -circulation_biomarker_diagnosis_down hsa-mir-198 Lung Neoplasms 23354517 Circulating;Downregulation of cell-free miR-198 as a diagnostic biomarker for lung adenocarcinoma-associated malignant pleural effusion -circulation_biomarker_diagnosis_down hsa-mir-150 Sepsis 23372743 Circulating;Circulating MicroRNA-150 Serum Levels Predict Survival in Patients with Critical Illness and Sepsis -circulation_biomarker_diagnosis_down hsa-mir-30a Breast Neoplasms 23389917 plasma; plasma miRNA-30a decreased in patients with BC and has great potential to use as novel biomarkers for BC diagnosis -circulation_biomarker_diagnosis_down hsa-mir-106a Systemic Lupus Erythematosus 23401079 "Seven miRNAs were statistically significantly differentially expressed in plasma from patients with SLE. The expression of miRNA-142-3p (miR-142-3p) and miR-181a was increased, and the expression of miR-106a, miR-17, miR-20a, miR-203,and miR-92a was decreased" -circulation_biomarker_diagnosis_down hsa-mir-17 Systemic Lupus Erythematosus 23401079 "Seven miRNAs were statistically significantly differentially expressed in plasma from patients with SLE. The expression of miRNA-142-3p (miR-142-3p) and miR-181a was increased, and the expression of miR-106a, miR-17, miR-20a, miR-203,and miR-92a was decreased" -circulation_biomarker_diagnosis_down hsa-mir-203 Systemic Lupus Erythematosus 23401079 "Seven miRNAs were statistically significantly differentially expressed in plasma from patients with SLE. The expression of miRNA-142-3p (miR-142-3p) and miR-181a was increased, and the expression of miR-106a, miR-17, miR-20a, miR-203,and miR-92a was decreased" -circulation_biomarker_diagnosis_down hsa-mir-20a Systemic Lupus Erythematosus 23401079 "Seven miRNAs were statistically significantly differentially expressed in plasma from patients with SLE. The expression of miRNA-142-3p (miR-142-3p) and miR-181a was increased, and the expression of miR-106a, miR-17, miR-20a, miR-203,and miR-92a was decreased" -circulation_biomarker_diagnosis_down hsa-mir-92a Systemic Lupus Erythematosus 23401079 "Seven miRNAs were statistically significantly differentially expressed in plasma from patients with SLE. The expression of miRNA-142-3p (miR-142-3p) and miR-181a was increased, and the expression of miR-106a, miR-17, miR-20a, miR-203,and miR-92a was decreased" -circulation_biomarker_diagnosis_down hsa-mir-133 Heart Failure 23711953 "In surgical CAD patients, a decreased miR-133 expression is associated with variables characteristic of heart failure." -circulation_biomarker_diagnosis_down hsa-mir-197 Primary Biliary Cirrhosis 23776611 Our results indicate that sera from patients with PBC have a unique mirNA expression profile and that the down-regulated expression of mir-505-3p and mir-197-3p can serve as clinical biomarkers of PBC. -circulation_biomarker_diagnosis_down hsa-mir-505 Primary Biliary Cirrhosis 23776611 Our results indicate that sera from patients with PBC have a unique mirNA expression profile and that the down-regulated expression of mir-505-3p and mir-197-3p can serve as clinical biomarkers of PBC. -circulation_biomarker_diagnosis_down hsa-let-7f Alzheimer Disease 23895045 A blood based 12-miRNA signature of Alzheimer disease patients. -circulation_biomarker_diagnosis_down hsa-mir-103a Alzheimer Disease 23895045 A blood based 12-miRNA signature of Alzheimer disease patients. -circulation_biomarker_diagnosis_down hsa-mir-107 Alzheimer Disease 23895045 A blood based 12-miRNA signature of Alzheimer disease patients. -circulation_biomarker_diagnosis_down hsa-mir-1285 Alzheimer Disease 23895045 A blood based 12-miRNA signature of Alzheimer disease patients. -circulation_biomarker_diagnosis_down hsa-mir-26a Alzheimer Disease 23895045 A blood based 12-miRNA signature of Alzheimer disease patients. -circulation_biomarker_diagnosis_down hsa-mir-26b Alzheimer Disease 23895045 A blood based 12-miRNA signature of Alzheimer disease patients. -circulation_biomarker_diagnosis_down hsa-mir-532 Alzheimer Disease 23895045 A blood based 12-miRNA signature of Alzheimer disease patients. -circulation_biomarker_diagnosis_down hsa-mir-145 Myasthenia Gravis 24043548 Identification of novel MicroRNA signatures linked to experimental autoimmune myasthenia gravis pathogenesis: down-regulated miR-145 promotes pathogenetic Th17 cell response. -circulation_biomarker_diagnosis_down hsa-mir-21 Leukemia 24141112 "Moreover, the down-regulated expression of microRNA-21 in DF-1 chicken fibroblast cells infected with subgroup J avian leukemia virus (ALVs) was confirmed by the developed method, indicating that microRNA-21 might be a new biomarker for avian leukemia." -circulation_biomarker_diagnosis_down hsa-mir-15b Multiple Sclerosis 24277735 Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis. -circulation_biomarker_diagnosis_down hsa-mir-223 Multiple Sclerosis 24277735 Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis. -circulation_biomarker_diagnosis_down hsa-mir-23a Multiple Sclerosis 24277735 Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis. -circulation_biomarker_diagnosis_down hsa-mir-1 Polycystic Kidney Disease 24489795 "We found that in ADPKD urine specimens, miRNA previously implicated as kidney tumor suppressors (miR-1 and miR-133), as well as miRNA of presumed inflammatory and fibroblast cell origin (miR-223/miR-199), are dysregulated when compared to other CKD patients. Concordant with findings in the primary tubule epithelial cell model, this suggests roles for dysregulated miRNA in ADPKD pathogenesis and potential use as biomarkers. We intend to assess prognostic potential of miRNA in a followup analysis." -circulation_biomarker_diagnosis_down hsa-mir-29a Parkinson Disease 24648008 "We found four statistically significant miRNAs that were downregulated in either LRRK2 or IPD (miR-29a, miR-29c, miR-19a, and miR-19b)." -circulation_biomarker_diagnosis_down hsa-mir-96 "Leukemia, Myeloid, Acute" 24678958 "Our data demonstrated that the expression of miR-96 was downregulated in newly diagnosed AML patients and associated with leukemic burden, as well as RFS and OS. This suggests that miR-96 detection might become a potential biomarker of prognosis and monitoring in AML." -circulation_biomarker_diagnosis_down hsa-mir-199b "Leukemia, Myeloid, Chronic" 24680705 Down-regulation of miR-199b associated with imatinib drug resistance in 9q34.1 deleted BCR/ABL positive CML patients. -circulation_biomarker_diagnosis_down hsa-let-7e Retinoblastoma 24748987 "Plasma miRNA (miR)-320, miR-let-7e and miR-21 levels were downregulated in the patient samples" -circulation_biomarker_diagnosis_down hsa-mir-146 "Diabetes Mellitus, Type 1" 24796653 Decreased miR-146 expression in peripheral blood mononuclear cells is correlated with ongoing islet autoimmunity in type 1 diabetes patients 1miR-146. -circulation_biomarker_diagnosis_down hsa-mir-125b Melanoma 24878024 "Exosomes can provide a suitable material to measure circulating miRNA in melanoma, and miR-16 can be used as an endogenous normalizer. Lower levels of miR-125b in exosomes obtained from serum are associated with advanced melanoma disease, probably reflecting the tumoral cell dysregulation." -circulation_biomarker_diagnosis_down hsa-mir-16 Melanoma 24878024 "Exosomes can provide a suitable material to measure circulating miRNA in melanoma, and miR-16 can be used as an endogenous normalizer. Lower levels of miR-125b in exosomes obtained from serum are associated with advanced melanoma disease, probably reflecting the tumoral cell dysregulation." -circulation_biomarker_diagnosis_down hsa-mir-107 Diabetes Mellitus 24908639 "Hyperglycemia may downregulate the expressions of miR-223 and miR-146a, leading to subsequent platelet activation in patients with diabetes mellitus. Low platelet and plasma miR-223 and miR-146a expression is a risk factor for ischemic stroke in Chinese diabetes mellitus patients." -circulation_biomarker_diagnosis_down hsa-mir-146a Diabetes Mellitus 24908639 "Hyperglycemia may downregulate the expressions of miR-223 and miR-146a, leading to subsequent platelet activation in patients with diabetes mellitus. Low platelet and plasma miR-223 and miR-146a expression is a risk factor for ischemic stroke in Chinese diabetes mellitus patients." -circulation_biomarker_diagnosis_down hsa-mir-223 Diabetes Mellitus 24908639 "Hyperglycemia may downregulate the expressions of miR-223 and miR-146a, leading to subsequent platelet activation in patients with diabetes mellitus. Low platelet and plasma miR-223 and miR-146a expression is a risk factor for ischemic stroke in Chinese diabetes mellitus patients." -circulation_biomarker_diagnosis_down hsa-mir-495 Diabetes Mellitus 24908639 "Hyperglycemia may downregulate the expressions of miR-223 and miR-146a, leading to subsequent platelet activation in patients with diabetes mellitus. Low platelet and plasma miR-223 and miR-146a expression is a risk factor for ischemic stroke in Chinese diabetes mellitus patients." -circulation_biomarker_diagnosis_down hsa-let-7b Crohn Disease 24910152 Both inflamed and non-inflamed terminal ileal mucosa in adult patients with active CD have their distinct miRNA expression patterns compared with healthy controls. Dysregulated miRNAs may be responsible for pathogenesis of CD. -circulation_biomarker_diagnosis_down hsa-mir-9-1 Methylmalonic Acidemia 24927441 "Plasma miR-9-1 is significantly down-regulated in MMA patients, but it is significantly up-regulated after vitamin B12 treatment, suggesting that miR-9-1 may act as a biomarker in monitoring the progression of MMA." -circulation_biomarker_diagnosis_down hsa-mir-155 Sjogren Syndrome 24931100 "Our results demonstrated miR-146a overexpression and miR-155 underexpression in the peripheral mononuclear blood cells of the patients with pSS. Furthermore, the expression levels of these miRNAs correlated with the patients' clinical features. Our data suggest that miR-146a and miR-155 might play important roles in the pathogenesis of pSS and that their expression levels may be useful for diagnosing pSS and for predicting disease activity and therapeutic responses." -circulation_biomarker_diagnosis_down hsa-mir-1 Bladder Neoplasms 25015192 Hsa-miR-1 downregulates long non-coding RNA urothelial cancer associated 1 in bladder cancer. -circulation_biomarker_diagnosis_down hsa-mir-16 Heart Failure 25033200 "We provide evidence that miR-16 decreases in the circulation of end-stage HF patients and increases with a LVAD. Modeling studies suggest that miR-16 binds to and decreases expression of VPS4a. Overexpression of VPS4a decreases cell number. Together, these experiments suggest that miR-16 and VPS4a expression are altered in end-stage HF and in response to unloading with a LVAD. This signaling pathway may lead to reduced circulating cell number in HF." -circulation_biomarker_diagnosis_down hsa-mir-195 Breast Neoplasms 25103018 Serum microRNA-195 is down-regulated in breast cancer: a potential marker for the diagnosis of breast cancer. -circulation_biomarker_diagnosis_down hsa-mir-181b Autism Spectrum Disorder 25126405 "MiR-151a-3p, miR-181b-5p, miR-320a, miR-328, miR-433, miR-489, miR-572, and miR-663a were downregulated, while miR-101-3p, miR-106b-5p, miR-130a-3p, miR-195-5p, and miR-19b-3p were upregulated." -circulation_biomarker_diagnosis_down hsa-mir-21 Rheumatoid Arthritis 25164131 Decreased expression of microRNA-21 correlates with the imbalance of Th17 and Treg cells in patients with rheumatoid arthritis. -circulation_biomarker_diagnosis_down hsa-mir-146b "Fatty Liver, Non-Alcoholic" 25232454 "Serum levels of miR-181d, miR-99a, miR-197 and miR-146b were significantly lower in biopsy-proven NAFLD patients than in the healthy controls." -circulation_biomarker_diagnosis_down hsa-mir-29a "Fatty Liver, Non-Alcoholic" 25232454 "Serum levels of miR-181d, miR-99a, miR-197 and miR-146b were significantly lower in biopsy-proven NAFLD patients than in the healthy controls." -circulation_biomarker_diagnosis_down hsa-mir-124 Stroke 25257664 serum miR-124 was significantly decreased within 24 hours after stroke onset and serum miR-9 was decreased in patients with larger stroke. -circulation_biomarker_diagnosis_down hsa-mir-9 Stroke 25257664 serum miR-124 was significantly decreased within 24 hours after stroke onset and serum miR-9 was decreased in patients with larger stroke. -circulation_biomarker_diagnosis_down hsa-mir-150 Sepsis 25394245 "The expression of two miRNAs, that is, let-7a (P < 0.001) and miR-150 (P < 0.001), were confirmed to be significantly downregulated in GNB urosepsis patients compared with healthy controls." -circulation_biomarker_diagnosis_down hsa-mir-320a Multiple Sclerosis 25468268 expression of miR-320a is decreased in B cells of MS patients and may contribute to increased blood-brain barrier permeability and neurological disability. -circulation_biomarker_diagnosis_down hsa-mir-210 Acute Cerebral Infarction 25476086 "The serum level of miR-210 in ACI was significantly lower than that in normal healthy persons, and it may be an important new serological marker in screening and diagnosis of ACI." -circulation_biomarker_diagnosis_down hsa-mir-146a "Diabetes Mellitus, Type 2" 25500583 "decreased serum anti-inflammatory miR-146a, increased pro-inflammatory IL-8 and increased HGF (a vascular/insular repair factor) as discriminating markers of failure of glucose control occurring on the background of obesity and dyslipidemia." -circulation_biomarker_diagnosis_down hsa-mir-155 "Diabetes Mellitus, Type 2" 25500583 "decreased serum anti-inflammatory miR-146a, increased pro-inflammatory IL-8 and increased HGF (a vascular/insular repair factor) as discriminating markers of failure of glucose control occurring on the background of obesity and dyslipidemia." -circulation_biomarker_diagnosis_down hsa-mir-22 Premature Ovarian Failure 25585503 Mir-22-3p showed a lower expression level in POF and was modestly effective in distinguishing POF from control subjects. The decreased expression of miR-22-3p in plasma of POF may reflect the diminished ovarian reserve and be a consequence of the pathologic process of POF. -circulation_biomarker_diagnosis_down hsa-mir-1 Arrhythmia 25625292 patients with SVT had lower miR-1 expression levels while those with VT had higher miR-133 expression levels. -circulation_biomarker_diagnosis_down hsa-mir-223 "Leukemia, Myeloid, Acute" 25793640 MIR233 is genetically or epigenetically silenced in a subset of acute myeloid leukemia (AML). -circulation_biomarker_diagnosis_down hsa-mir-218 "Carcinoma, Esophageal" 25812647 "The serum expression of miR-218 is downregulated in esophageal cancer patients and is correlated with tumor differentiation, stage, and lymph node metastasis. Serum miR-218 may be a potential biomarker for early detection and clinical evaluation in patient with esophageal cancer." -circulation_biomarker_diagnosis_down hsa-mir-181b Atherosclerosis 25896908 Hyperlipidemia reduced the expression of miR-181b and increased NT and N/M ratio. -circulation_biomarker_diagnosis_down hsa-mir-16 Plasmodium vivax Infection 25913668 Downregulation of plasma miR-451 and miR-16 in Plasmodium vivax infection. -circulation_biomarker_diagnosis_down hsa-mir-451 Plasmodium vivax Infection 25913668 Downregulation of plasma miR-451 and miR-16 in Plasmodium vivax infection. -circulation_biomarker_diagnosis_down hsa-mir-148a "Leukemia, Myeloid, Acute" 25924238 whilst anti-oncogenic microRNAsincluding miR-148a and miR-193a were down-regulated in MAPKBP1high patients with CN-AML -circulation_biomarker_diagnosis_down hsa-mir-214 Acute Myocardial Infarction 25931214 "The circulating level of miR-214 was significantly decreased in the AMI group, which might be correlated with the extent of the coronary lesion.Circulating miR-214 may be a promising biomarker for the diagnosis and prognosis of severe AMI." -circulation_biomarker_diagnosis_down hsa-mir-145 Coronary Artery Disease 25938589 "Lower plasma levels of miRNA-145 were significantly associated with the presence as well as severity of CAD. As a potential biomarker for CAD, plasma miRNA-145 may be useful in predicting CAD and its severity in patients presenting with chest pain." -circulation_biomarker_diagnosis_down hsa-mir-22 Rheumatoid Arthritis 25939484 "MiRNAs with a P-value <0.05 using three different normalizations were included in a multivariate model.After backwards elimination, the combination of low expression of miR-22 and high expression of miR-886.3p was associated with EULAR good response. Future studies to assess the utility of these miRNAs as predictive biomarkers are needed." -circulation_biomarker_diagnosis_down hsa-mir-181c Myasthenia Gravis 25962782 Decreased microRNA miR-181c expression in peripheral blood mononuclear cells correlates with elevated serum levels of IL-7 and IL-17 in patients with myasthenia gravis. -circulation_biomarker_diagnosis_down hsa-mir-130a Spinal Cord Injuries 25973054 Increased HDAC3 and decreased miRNA-130a expression in PBMCs through recruitment HDAC3 in patients with spinal cord injuries. -circulation_biomarker_diagnosis_down hsa-mir-126 Atherosclerosis 25975504 miR-126 and miR-223 platelets were reduced in the rabbit atherosclerotic plaque model group -circulation_biomarker_diagnosis_down hsa-mir-33b Multiple Myeloma 25975752 Downregulated miR-33b is a novel predictor associated with disease progression and poor prognosis in multiple myeloma. -circulation_biomarker_diagnosis_down hsa-mir-374a Hypoxic-Ischemic Encephalopathy 26001314 We have shown a significant step-wise downregulation of hsa-miR-374a expression in cord blood of infants with perinatal asphyxia and subsequent HIE. -circulation_biomarker_diagnosis_down hsa-mir-146a "Stroke, Ischemic" 26044809 miR-146a and miR-185 were present with quite low abundance in ISA compared with healthy individuals -circulation_biomarker_diagnosis_down hsa-mir-143 Alzheimer Disease 26078483 "The results showed that four miRNAs (miR-31, miR-93, miR-143, and miR-146a) were markedly decreased in AD patients'serum compared with controls." -circulation_biomarker_diagnosis_down hsa-mir-146a Alzheimer Disease 26078483 "The results showed that four miRNAs (miR-31, miR-93, miR-143, and miR-146a) were markedly decreased in AD patients'serum compared with controls." -circulation_biomarker_diagnosis_down hsa-mir-31 Alzheimer Disease 26078483 "The results showed that four miRNAs (miR-31, miR-93, miR-143, and miR-146a) were markedly decreased in AD patients'serum compared with controls." -circulation_biomarker_diagnosis_down hsa-mir-93 Alzheimer Disease 26078483 "The results showed that four miRNAs (miR-31, miR-93, miR-143, and miR-146a) were markedly decreased in AD patients'serum compared with controls." -circulation_biomarker_diagnosis_down hsa-mir-378 Dengue Virus Infection 26166761 "This study found that miR-27a*, miR-30e, and miR-378 were down-regulated in DENV-infected patients" -circulation_biomarker_diagnosis_down hsa-mir-155 Diabetes Mellitus 26188366 Downregulated microRNA-155 expression in peripheral blood mononuclear cells of type 2 diabetic patients is not correlated with increased inflammatory cytokine production. -circulation_biomarker_diagnosis_down hsa-mir-130b Heart Failure 26211628 MiR-130b levels were reduced in obese HF patients compared with HF lean (P=0.036) and controls (P=0.025). -circulation_biomarker_diagnosis_down hsa-mir-143 Obesity 26223376 "Circulating miR-335 (Pâ€?â€?.001), miR-143 (Pâ€?â€?.001) and miR-758 (Pâ€?â€?.006) in obese children were significantly lower than those of controls." -circulation_biomarker_diagnosis_down hsa-mir-335 Obesity 26223376 "Circulating miR-335 (Pâ€?â€?.001), miR-143 (Pâ€?â€?.001) and miR-758 (Pâ€?â€?.006) in obese children were significantly lower than those of controls." -circulation_biomarker_diagnosis_down hsa-mir-205 Glioma 26230475 Downregulation of serum microRNA-205 as a potential diagnostic and prognostic biomarker for human glioma. -circulation_biomarker_diagnosis_down hsa-mir-203 Gastric Neoplasms 26233325 serum miR-203 levels were significantly lower in stage IV than stage I-III GC patients. -circulation_biomarker_diagnosis_down hsa-mir-126 Diabetes Mellitus 26299579 Diabetes mellitus -circulation_biomarker_diagnosis_down hsa-mir-181b Atherosclerosis 26420120 The serum miR-181b level was significantly reduced in patients with atherosclerosis. miR-181b may function as an atherosclerosis suppressor by interupting the NF-¦ÊB pathway in endothelial cells and inhibiting the proliferation and migration of vascular smooth muscle cells. -circulation_biomarker_diagnosis_down hsa-mir-15a Diabetes Mellitus 26460159 "These results demonstrated that peripheral blood miR-15a expression levels were significantly lower in patients with T2D and IFG/IGT individuals, compared with healthy individuals. Thus, miR-15a in peripheral whole blood may serve as a potential biomarker for T2D and pre-diabetes." -circulation_biomarker_diagnosis_down hsa-mir-106a Cholangiocarcinoma 26534789 "Together, reduced expression of serum miR-106a is a powerful prognostic indicator for CCA patients. The dismal outcome of these CCA patients might correlate with a higher risk of lymph node metastasis." -circulation_biomarker_diagnosis_down hsa-mir-27a Acute Heart Failure 26569364 "The increase in creatinine during the first 3 days of hospitalization was significantly associated with lower levels of miR-199a-3p, miR-27a-3p, miR-652-3p, miR-423-5p, and miR-let-7i-5p" -circulation_biomarker_diagnosis_down hsa-mir-126 Acute Heart Failure 26580972 Levels of miR-126 and miR-423-5p were lower in AHF and in non-AHF patients compared to stable CHF patients (both p<0.001). -circulation_biomarker_diagnosis_down hsa-mir-122 Stroke 26661204 our recent studies have demonstrated that miR-122 decreased in whole blood of patients and in whole blood of rats following ischemic stroke -circulation_biomarker_diagnosis_down hsa-mir-150 Spondylarthritis 26689798 miR-150 was downregulated in all of the samples -circulation_biomarker_diagnosis_down hsa-mir-181a "Leukemia, Myeloid, Chronic" 26722250 The expression levels of miR-181a were significantly reduced in the patient with CML and in the CML K562 cell line. -circulation_biomarker_diagnosis_down hsa-mir-106b Human Immunodeficiency Virus Infection 26755399 we found that the miRNAs miR-106b and miR-20a that target p21 were specifically downregulated in HIV-1 infected CD4+ T cells. -circulation_biomarker_diagnosis_down hsa-mir-20a Human Immunodeficiency Virus Infection 26755399 we found that the miRNAs miR-106b and miR-20a that target p21 were specifically downregulated in HIV-1 infected CD4+ T cells. -circulation_biomarker_diagnosis_down hsa-mir-146a "Squamous Cell Carcinoma, Esophageal" 26794279 MicroRNA-146a is significantly reduced in cancerous tissue and serum samples of ESCC patients. It is an ideal biomarker for the prognosis and diagnosis of ESCC. -circulation_biomarker_diagnosis_down hsa-mir-221 Prostate Neoplasms 26831660 downregulation of hsa-miR-221* (now hsa-miR-221-5p) and hsa-miR-708* (now hsa-miR-708-3p) in PCa compared to BPH. -circulation_biomarker_diagnosis_down hsa-mir-708 Prostate Neoplasms 26831660 downregulation of hsa-miR-221* (now hsa-miR-221-5p) and hsa-miR-708* (now hsa-miR-708-3p) in PCa compared to BPH. -circulation_biomarker_diagnosis_down hsa-mir-199b "Leukemia, Myeloid, Acute" 26848406 Low miR-199b in AML patients correlates with worse overall survival and has prognostic significance for FAB-M5 subtype. -circulation_biomarker_diagnosis_down hsa-mir-199b Polycystic Ovarian Syndrome 26860517 whereas that of miR-199b-5p was down-regulated. -circulation_biomarker_diagnosis_down hsa-mir-34b "Leukemia, Myeloid, Acute, Pediatric" 26861642 miRâ€?4b levels in leukemia cell lines and primary leukemic cells were significantly lower than those in normal cells. -circulation_biomarker_diagnosis_down hsa-mir-194 Cholangiocarcinoma 26864161 miR-483-5p and miR-194 showed deregulated expression in CC compared with controls. -circulation_biomarker_diagnosis_down hsa-mir-483 Cholangiocarcinoma 26864161 whereas miR-483-5p and miR-194 showed deregulated expression in CC compared with controls -circulation_biomarker_diagnosis_down hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 26908869 Downregulation of miR-15a and miR-16-1 at 13q14 in Chronic Lymphocytic Leukemia. -circulation_biomarker_diagnosis_down hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 26908869 Downregulation of miR-15a and miR-16-1 at 13q14 in Chronic Lymphocytic Leukemia. -circulation_biomarker_diagnosis_down hsa-mir-126 Diabetes Mellitus 27005938 "Among those, miR-126 and miR-26a were significantly reduced in diabetic patients compared to non-diabetic patients." -circulation_biomarker_diagnosis_down hsa-mir-20a Endometriosis 27049094 "For recurred cases, miR-199 showed a remarkably high expression and miR-17-5p and miR-20a expressed significantly low." -circulation_biomarker_diagnosis_down hsa-mir-155 Chronic Hepatitis B 27110261 "In the HBV-infected patients, the miR-155 levels were significantly lower than in the healthy controls" -circulation_biomarker_diagnosis_down hsa-mir-106a Aortic Stenosis 27129184 "Levels of miR-30c were higher in the AS group than in the controls (P<0.01), whereas levels of miR-106a, miR-148a, miR-204, miR-211, miR-31 and miR-424 were lower in the AS group than in the controls (P<0.01)." -circulation_biomarker_diagnosis_down hsa-mir-148a Aortic Stenosis 27129184 "Levels of miR-30c were higher in the AS group than in the controls (P<0.01), whereas levels of miR-106a, miR-148a, miR-204, miR-211, miR-31 and miR-424 were lower in the AS group than in the controls (P<0.01)." -circulation_biomarker_diagnosis_down hsa-mir-204 Aortic Stenosis 27129184 "Levels of miR-30c were higher in the AS group than in the controls (P<0.01), whereas levels of miR-106a, miR-148a, miR-204, miR-211, miR-31 and miR-424 were lower in the AS group than in the controls (P<0.01)." -circulation_biomarker_diagnosis_down hsa-mir-211 Aortic Stenosis 27129184 "Levels of miR-30c were higher in the AS group than in the controls (P<0.01), whereas levels of miR-106a, miR-148a, miR-204, miR-211, miR-31 and miR-424 were lower in the AS group than in the controls (P<0.01)." -circulation_biomarker_diagnosis_down hsa-mir-30a Aortic Stenosis 27129184 "Levels of miR-30c were higher in the AS group than in the controls (P<0.01), whereas levels of miR-106a, miR-148a, miR-204, miR-211, miR-31 and miR-424 were lower in the AS group than in the controls (P<0.01)." -circulation_biomarker_diagnosis_down hsa-mir-31 Aortic Stenosis 27129184 "Levels of miR-30c were higher in the AS group than in the controls (P<0.01), whereas levels of miR-106a, miR-148a, miR-204, miR-211, miR-31 and miR-424 were lower in the AS group than in the controls (P<0.01)." -circulation_biomarker_diagnosis_down hsa-mir-424 Aortic Stenosis 27129184 "Levels of miR-30c were higher in the AS group than in the controls (P<0.01), whereas levels of miR-106a, miR-148a, miR-204, miR-211, miR-31 and miR-424 were lower in the AS group than in the controls (P<0.01)." -circulation_biomarker_diagnosis_down hsa-mir-1297 "Squamous Cell Carcinoma, Esophageal" 27152453 It was statistically decreased in ESCC patients compared with healthy controls. -circulation_biomarker_diagnosis_down hsa-mir-125b "Carcinoma, Hepatocellular, HBV-Related" 27152955 The levels of plasma miR-125b were remarkably decreased in HBV-HCC patients compared to healthy controls -circulation_biomarker_diagnosis_down hsa-mir-181a Human Immunodeficiency Virus Infection 27171002 "hsa-miR-155 and hsa-miR-181a were downregulated in VP whereas in the other groups, either an upregulation or no differences were observed after stimulation, respectively." -circulation_biomarker_diagnosis_down hsa-mir-200c Breast Neoplasms 27197674 "miR-21 (P < 0.001) and miR-146a (P = 0.001) were overexpressed, whereas miR-200c (P = 0.004) and miR-210 (P = 0.002) were underexpressed." -circulation_biomarker_diagnosis_down hsa-mir-210 Breast Neoplasms 27197674 "miR-21 (P < 0.001) and miR-146a (P = 0.001) were overexpressed, whereas miR-200c (P = 0.004) and miR-210 (P = 0.002) were underexpressed." -circulation_biomarker_diagnosis_down hsa-mir-182 Atherosclerosis 27199451 Atherosclerotic lesions from patients with high asymmetrical dimethylarginine plasma levels exhibited decreased miR-182-3p expression levels and elevated MYADM expression levels. -circulation_biomarker_diagnosis_down hsa-mir-181a Allergic Rhinitis 27199509 The OPN protein and miR-181a levels may serve as predictors of disease severity in childhood AR and appear to be promising targets for modulating AR. -circulation_biomarker_diagnosis_down hsa-mir-19a Lung Fibrosis 27312312 miR-19a in peripheral blood leukocyte could be used as an effective biomarker for silicosis -circulation_biomarker_diagnosis_down hsa-mir-126 Coronary Artery Disease 27321479 MiR-126 strongly associated with T2D and CAD -circulation_biomarker_diagnosis_down hsa-mir-126 "Diabetes Mellitus, Type 2" 27321479 "expression levels of circulating miR-126, determined by quantitative real time PCR, were decrease in peripheral blood of T2D patients and T2D with CAD compared with healthy controls." -circulation_biomarker_diagnosis_down hsa-mir-30 Atherosclerosis 27379414 circulating miR-30 might be used as a biomarker for atherosclerosis -circulation_biomarker_diagnosis_down hsa-mir-375 Diabetes Mellitus 27383196 lower circulating levels of miR-192 and miR-375 compared to CD period -circulation_biomarker_diagnosis_down hsa-mir-4505 Anxiety Disorders 27423364 "Results showed that the level of miR-4505 and miR-663 was negatively correlated with the total HAMA scores in GAD patients (r=0.2228, r=0.264 P<0.05)." -circulation_biomarker_diagnosis_down hsa-mir-663 Anxiety Disorders 27423364 "esults showed that the level of miR-4505 and miR-663 was negatively correlated with the total HAMA scores in GAD patients (r=0.2228, r=0.264 P<0.05)." -circulation_biomarker_diagnosis_down hsa-mir-320b Carotid Artery Diseases 27460454 Low serum miR-320b expression as a novel indicator of carotid atherosclerosis. -circulation_biomarker_diagnosis_down hsa-mir-335 Spinal Muscular Atrophy 27483257 The expression of miR-335-5p; already identified to control self-renewal or differentiation of mouse embryonic stem cells (mESCs); resulted to be reduced during the early steps of differentiation of SMA hiPSCs compared to wild type cells. -circulation_biomarker_diagnosis_down hsa-mir-31 Systemic Lupus Erythematosus 27510529 "The results revealed that miR-31 was lower expressed, while miR-21 was high expressed in SLE patients compared to their first-degree relatives and controls." -circulation_biomarker_diagnosis_down hsa-mir-200b Kideny Transplant Rejection 27521993 our findings indicated that the aberrant urinary miR-21 and miR-200b expression levels were accompanied with renal allograft dysfunction and IFTA. -circulation_biomarker_diagnosis_down hsa-mir-29a "Leukemia, Lymphoblastic" 27535859 "The expression of hsa-miR-29a , hsa-miR-126 and has-miR-181 family were significantly different in B-ALL." -circulation_biomarker_diagnosis_down hsa-mir-663 Leukemia 27535859 "The expression of hsa-miR-29a , hsa-miR-126 and has-miR-181 family were significantly different in B-ALL." -circulation_biomarker_diagnosis_down hsa-mir-150 Cholangiocarcinoma 27658773 Profiling of downregulated blood-circulating miR-150-5p as a novel tumor marker for cholangiocarcinoma. -circulation_biomarker_diagnosis_down hsa-mir-155 "Fatty Liver, Non-Alcoholic" 27832630 Decreased MiR-155 Level in the Peripheral Blood of Non-Alcoholic Fatty Liver Disease Patients may Serve as a Biomarker and may Influence LXR Activity. -circulation_biomarker_diagnosis_down hsa-mir-335 Acute Ischemic Stroke 27856935 Decreased plasma miR-335 expression in patients with acute ischemic stroke and its association with calmodulin expression. -circulation_biomarker_diagnosis_down hsa-mir-126 Cardiovascular Diseases [unspecific] 28065883 Down-regulation of proangiogenic microRNA-126 and microRNA-132 are early modulators of diabetic cardiac microangiopathy. -circulation_biomarker_diagnosis_down hsa-mir-132 Cardiovascular Diseases [unspecific] 28065883 Down-regulation of proangiogenic microRNA-126 and microRNA-132 are early modulators of diabetic cardiac microangiopathy. -circulation_biomarker_diagnosis_down hsa-mir-27a Heart Failure 28293796 Low circulating microRNA levels in heart failure patients are associated with atherosclerotic disease and cardiovascular-related rehospitalizations. -circulation_biomarker_diagnosis_down hsa-mir-204 Aortic Valve Disease 28377507 miR-486 inhibits Smurf2 expression to augment the miR-204 down-regulation -circulation_biomarker_diagnosis_down hsa-mir-150 "Leukemia, Lymphocytic, Chronic, B-Cell" 28407516 Quantitative miR analysis in chronic lymphocytic leukaemia/small lymphocytic lymphoma - proliferation centres are characterized by high miR-92a and miR-155 and low miR-150 expression. -circulation_biomarker_diagnosis_down hsa-mir-155 Myocardial Infarction 28618412 Failed Downregulation of Circulating MicroRNA-155 in the Early Phase after ST Elevation Myocardial Infarction Is Associated with Adverse Left Ventricular Remodeling. -circulation_biomarker_diagnosis_down hsa-mir-133a Vascular Hypertrophy 28772031 Local microRNA-133a downregulation is associated with hypertrophy in the dyssynchronous heart. -circulation_biomarker_diagnosis_down hsa-let-7f "Leukemia, Lymphoblastic, Acute, Childhood" 28910942 "The expression levels of let-7f-5p, miR-5100 and miR-25-3p in the cALL patients were significantly lower than those of the controls" -circulation_biomarker_diagnosis_down hsa-mir-25 "Leukemia, Lymphoblastic, Acute, Childhood" 28910942 "The expression levels of let-7f-5p, miR-5100 and miR-25-3p in the cALL patients were significantly lower than those of the controls" -circulation_biomarker_diagnosis_down hsa-mir-5100 "Leukemia, Lymphoblastic, Acute, Childhood" 28910942 "The expression levels of let-7f-5p, miR-5100 and miR-25-3p in the cALL patients were significantly lower than those of the controls" -circulation_biomarker_diagnosis_down hsa-mir-126 Coronary Artery Disease 29062343 miR-126 expression was significantly down-regulated in the circulation of CAD patients compared with control subjects -circulation_biomarker_diagnosis_down hsa-mir-18a "Leukemia, Lymphoblastic, Acute" 29068867 Low Expression of miR-18a as a Characteristic of Pediatric Acute Lymphoblastic Leukemia. -circulation_biomarker_diagnosis_down hsa-mir-21 "Diabetes Mellitus, Type 2" 29113498 Decreased serum microRNA-21 level is associated with obesity in healthy and type 2 diabetic subjects. -circulation_biomarker_diagnosis_down hsa-mir-638 "Carcinoma, Hepatocellular" 29278659 Decreased levels of serum exosomal miR-638 predict poor prognosis in hepatocellular carcinoma. -circulation_biomarker_diagnosis_down hsa-mir-133a Myocardial Infarction 29324314 Down-regulation of miR-133a/b in patients with myocardial infarction correlates with the presence of ventricular fibrillation -circulation_biomarker_diagnosis_down hsa-mir-133b Myocardial Infarction 29324314 Down-regulation of miR-133a/b in patients with myocardial infarction correlates with the presence of ventricular fibrillation -circulation_biomarker_diagnosis_down hsa-mir-222 Preeclampsia 29381395 serum miR-222 expression levels showed a significant decrease in PE compared to GH and normotensive groups -circulation_biomarker_diagnosis_down hsa-mir-34a Pulmonary Hypertension 29431643 Circulatory miR-34a-3p expression is decreased in both patients with PAH and preclinical models of PAH -circulation_biomarker_diagnosis_down hsa-mir-204 Frontotemporal Dementia 29434051 Downregulation of exosomal miR-204-5p and miR-632 as a biomarker for FTD: a GENFI study. -circulation_biomarker_diagnosis_down hsa-mir-632 Frontotemporal Dementia 29434051 Downregulation of exosomal miR-204-5p and miR-632 as a biomarker for FTD: a GENFI study. -circulation_biomarker_diagnosis_down hsa-mir-17 Myocardial Infarction 29536180 Downregulation of microRNA-17-5p improves cardiac function after myocardial infarction via attenuation of apoptosis in endothelial cells. -circulation_biomarker_diagnosis_down hsa-mir-20a "Diabetes Mellitus, Gestational" 29556924 Decreased Expression of Circulating miR-20a-5p in South African Women with Gestational Diabetes Mellitus. -circulation_biomarker_diagnosis_down hsa-mir-221 Colorectal Carcinoma 29630521 "Following the overexpression of GAS5, the GAS5expressions was up-regulated and miR-221 expression was down-regulated; the rate of cell proliferation, migration and invasion were decreased" -circulation_biomarker_diagnosis_down hsa-mir-29a Spinal Stenosis 29749498 Detection of miR?29a in plasma of patients with lumbar spinal stenosis and the clinical significance. -circulation_biomarker_diagnosis_down hsa-let-7d Familial Mediterranean Fever 29787577 "four miRNAs were upregulated (miR-144-3p, miR-21-5p, miR-4454, and miR-451a), and three were downregulated (miR-107, let-7d-5p, and miR-148b-3p)" -circulation_biomarker_diagnosis_down hsa-mir-107 Familial Mediterranean Fever 29787577 "four miRNAs were upregulated (miR-144-3p, miR-21-5p, miR-4454, and miR-451a), and three were downregulated (miR-107, let-7d-5p, and miR-148b-3p)" -circulation_biomarker_diagnosis_down hsa-mir-148b Familial Mediterranean Fever 29787577 "four miRNAs were upregulated (miR-144-3p, miR-21-5p, miR-4454, and miR-451a), and three were downregulated (miR-107, let-7d-5p, and miR-148b-3p)" -circulation_biomarker_diagnosis_down hsa-mir-122 Preeclampsia 29800045 "Circulating levels of miR-126-3p, -146a-5p, and -122-5p were significantly decreased in women with premature ACS who reported prior PE compared to those with prior normotensive pregnancy" -circulation_biomarker_diagnosis_down hsa-mir-126 Preeclampsia 29800045 "Circulating levels of miR-126-3p, -146a-5p, and -122-5p were significantly decreased in women with premature ACS who reported prior PE compared to those with prior normotensive pregnancy" -circulation_biomarker_diagnosis_down hsa-mir-146a Preeclampsia 29800045 "Circulating levels of miR-126-3p, -146a-5p, and -122-5p were significantly decreased in women with premature ACS who reported prior PE compared to those with prior normotensive pregnancy" -circulation_biomarker_diagnosis_down hsa-mir-1246 Systemic Lupus Erythematosus 29873187 "Although the levels of many miRNAs were unaffected after passage through the plasma adsorption membrane, expression of some miRNAs, including miR-1246, miR-4732-5p, and miR-6088 are declined" -circulation_biomarker_diagnosis_down hsa-mir-4732 Systemic Lupus Erythematosus 29873187 "Although the levels of many miRNAs were unaffected after passage through the plasma adsorption membrane, expression of some miRNAs, including miR-1246, miR-4732-5p, and miR-6088 are declined" -circulation_biomarker_diagnosis_down hsa-mir-6088 Systemic Lupus Erythematosus 29873187 "Although the levels of many miRNAs were unaffected after passage through the plasma adsorption membrane, expression of some miRNAs, including miR-1246, miR-4732-5p, and miR-6088 are declined" -circulation_biomarker_diagnosis_down hsa-mir-194 Traumatic Brain Injury 29873258 miR-300-3p and miR-598-3p increased while miR-450-3p and miR-194-5p significantly decreased following TBI -circulation_biomarker_diagnosis_down hsa-mir-450 Traumatic Brain Injury 29873258 miR-300-3p and miR-598-3p increased while miR-450-3p and miR-194-5p significantly decreased following TBI -circulation_biomarker_diagnosis_down hsa-mir-128 Systemic Lupus Erythematosus 29873766 "miR-361-5p, miR-128-3p and miR-181a-2-3p expression was lower in patients with a high IFN signature (false discovery rate <0.05) as compared with patients with a low IFN signature and HCs." -circulation_biomarker_diagnosis_down hsa-mir-181a Systemic Lupus Erythematosus 29873766 "miR-361-5p, miR-128-3p and miR-181a-2-3p expression was lower in patients with a high IFN signature (false discovery rate <0.05) as compared with patients with a low IFN signature and HCs." -circulation_biomarker_diagnosis_down hsa-mir-361 Systemic Lupus Erythematosus 29873766 "miR-361-5p, miR-128-3p and miR-181a-2-3p expression was lower in patients with a high IFN signature (false discovery rate <0.05) as compared with patients with a low IFN signature and HCs." -circulation_biomarker_diagnosis_down hsa-mir-142 Acute Lung Injury 29904430 "9 miRNAs were significantly upregulated (miR-1843-3p, miR-323-3p, miR-183-5p, miR-182 and miR-196b-3p) or downregulated (miR-547-3p, miR-301b-5p, miR-503-3p and miR-142-3p)" -circulation_biomarker_diagnosis_down hsa-mir-301b Acute Lung Injury 29904430 "9 miRNAs were significantly upregulated (miR-1843-3p, miR-323-3p, miR-183-5p, miR-182 and miR-196b-3p) or downregulated (miR-547-3p, miR-301b-5p, miR-503-3p and miR-142-3p)" -circulation_biomarker_diagnosis_down hsa-mir-503 Acute Lung Injury 29904430 "9 miRNAs were significantly upregulated (miR-1843-3p, miR-323-3p, miR-183-5p, miR-182 and miR-196b-3p) or downregulated (miR-547-3p, miR-301b-5p, miR-503-3p and miR-142-3p)" -circulation_biomarker_diagnosis_down hsa-mir-547 Acute Lung Injury 29904430 "9 miRNAs were significantly upregulated (miR-1843-3p, miR-323-3p, miR-183-5p, miR-182 and miR-196b-3p) or downregulated (miR-547-3p, miR-301b-5p, miR-503-3p and miR-142-3p)" -circulation_biomarker_diagnosis_down hsa-mir-141 Parkinson Disease 29935433 "We identified differential expression of 10 miRNA of which 5 were upregulated in PD (miR-9-5p, miR-135a-5p, miR-135b-5p, miR-449a, and miR-449b-5p) and 5 downregulated (miR-141-3p, miR-199a-5p, miR-299-5p, miR-518e-3p, and miR-519a-3p)" -circulation_biomarker_diagnosis_down hsa-mir-199a Parkinson Disease 29935433 "We identified differential expression of 10 miRNA of which 5 were upregulated in PD (miR-9-5p, miR-135a-5p, miR-135b-5p, miR-449a, and miR-449b-5p) and 5 downregulated (miR-141-3p, miR-199a-5p, miR-299-5p, miR-518e-3p, and miR-519a-3p)" -circulation_biomarker_diagnosis_down hsa-mir-299 Parkinson Disease 29935433 "We identified differential expression of 10 miRNA of which 5 were upregulated in PD (miR-9-5p, miR-135a-5p, miR-135b-5p, miR-449a, and miR-449b-5p) and 5 downregulated (miR-141-3p, miR-199a-5p, miR-299-5p, miR-518e-3p, and miR-519a-3p)" -circulation_biomarker_diagnosis_down hsa-mir-518e Parkinson Disease 29935433 "We identified differential expression of 10 miRNA of which 5 were upregulated in PD (miR-9-5p, miR-135a-5p, miR-135b-5p, miR-449a, and miR-449b-5p) and 5 downregulated (miR-141-3p, miR-199a-5p, miR-299-5p, miR-518e-3p, and miR-519a-3p)" -circulation_biomarker_diagnosis_down hsa-mir-519a Parkinson Disease 29935433 "We identified differential expression of 10 miRNA of which 5 were upregulated in PD (miR-9-5p, miR-135a-5p, miR-135b-5p, miR-449a, and miR-449b-5p) and 5 downregulated (miR-141-3p, miR-199a-5p, miR-299-5p, miR-518e-3p, and miR-519a-3p)" -circulation_biomarker_diagnosis_down hsa-mir-151a Lupus Nephritis 29998838 Down-regulation of serum miR-151a-3p is associated with renal tissue activity in class IV lupus nephritis. -circulation_biomarker_diagnosis_down hsa-mir-15b Systemic Lupus Erythematosus 30008716 "the downregulated expression of miR-19b, miR-25, miR-93, and miR-15b was associated with SLE disease activity (P?0.7, including miR-24, miR-134, miR-146a, miR-378, miR-484, miR-628-3p, and miR-1825." -circulation_biomarker_diagnosis_ns hsa-mir-146a Pancreatic Neoplasms 23697990 "Several other circulating miRNAs distinguished sera of patients with pancreatic cancer from those of healthy controls with AUCs >0.7, including miR-24, miR-134, miR-146a, miR-378, miR-484, miR-628-3p, and miR-1825." -circulation_biomarker_diagnosis_ns hsa-mir-1825 Pancreatic Neoplasms 23697990 "Several other circulating miRNAs distinguished sera of patients with pancreatic cancer from those of healthy controls with AUCs >0.7, including miR-24, miR-134, miR-146a, miR-378, miR-484, miR-628-3p, and miR-1825." -circulation_biomarker_diagnosis_ns hsa-mir-24 Pancreatic Neoplasms 23697990 "Several other circulating miRNAs distinguished sera of patients with pancreatic cancer from those of healthy controls with AUCs >0.7, including miR-24, miR-134, miR-146a, miR-378, miR-484, miR-628-3p, and miR-1825." -circulation_biomarker_diagnosis_ns hsa-mir-378 Pancreatic Neoplasms 23697990 "Several other circulating miRNAs distinguished sera of patients with pancreatic cancer from those of healthy controls with AUCs >0.7, including miR-24, miR-134, miR-146a, miR-378, miR-484, miR-628-3p, and miR-1825." -circulation_biomarker_diagnosis_ns hsa-mir-484 Pancreatic Neoplasms 23697990 "Several other circulating miRNAs distinguished sera of patients with pancreatic cancer from those of healthy controls with AUCs >0.7, including miR-24, miR-134, miR-146a, miR-378, miR-484, miR-628-3p, and miR-1825." -circulation_biomarker_diagnosis_ns hsa-mir-628 Pancreatic Neoplasms 23697990 "Several other circulating miRNAs distinguished sera of patients with pancreatic cancer from those of healthy controls with AUCs >0.7, including miR-24, miR-134, miR-146a, miR-378, miR-484, miR-628-3p, and miR-1825." -circulation_biomarker_diagnosis_ns hsa-mir-122 "Carcinoma, Hepatocellular" 23723713 Circulating microRNA-122a as a diagnostic marker for hepatocellular carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-199a-1 Gastric Neoplasms 23733518 MiRNA-199a-3p: A Potential Circulating Diagnostic Biomarker for Early Gastric Cancer. -circulation_biomarker_diagnosis_ns hsa-mir-199a-2 Gastric Neoplasms 23733518 MiRNA-199a-3p: A Potential Circulating Diagnostic Biomarker for Early Gastric Cancer. -circulation_biomarker_diagnosis_ns hsa-mir-145 Heart Failure 23736534 "Changed circulating miRNA-26b-5p, miRNA-145-5p, miRNA-92a-3p, miRNA-30e-5p, and miRNA-29a-3p" -circulation_biomarker_diagnosis_ns hsa-mir-26b Heart Failure 23736534 "Changed circulating miRNA-26b-5p, miRNA-145-5p, miRNA-92a-3p, miRNA-30e-5p, and miRNA-29a-3p" -circulation_biomarker_diagnosis_ns hsa-mir-29a Heart Failure 23736534 "Changed circulating miRNA-26b-5p, miRNA-145-5p, miRNA-92a-3p, miRNA-30e-5p, and miRNA-29a-3p" -circulation_biomarker_diagnosis_ns hsa-mir-30e Heart Failure 23736534 "Changed circulating miRNA-26b-5p, miRNA-145-5p, miRNA-92a-3p, miRNA-30e-5p, and miRNA-29a-3p" -circulation_biomarker_diagnosis_ns hsa-mir-92a-1 Heart Failure 23736534 "Changed circulating miRNA-26b-5p, miRNA-145-5p, miRNA-92a-3p, miRNA-30e-5p, and miRNA-29a-3p" -circulation_biomarker_diagnosis_ns hsa-mir-92a-2 Heart Failure 23736534 "Changed circulating miRNA-26b-5p, miRNA-145-5p, miRNA-92a-3p, miRNA-30e-5p, and miRNA-29a-3p" -circulation_biomarker_diagnosis_ns hsa-mir-1-1 Myocardial Infarction 23747779 "Circulating miR-1, miR-208a, and miR-133a continuously rose during the first 4 h after induction of AMI." -circulation_biomarker_diagnosis_ns hsa-mir-1-2 Myocardial Infarction 23747779 "Circulating miR-1, miR-208a, and miR-133a continuously rose during the first 4 h after induction of AMI." -circulation_biomarker_diagnosis_ns hsa-mir-133a-1 Myocardial Infarction 23747779 "Circulating miR-1, miR-208a, and miR-133a continuously rose during the first 4 h after induction of AMI." -circulation_biomarker_diagnosis_ns hsa-mir-133a-2 Myocardial Infarction 23747779 "Circulating miR-1, miR-208a, and miR-133a continuously rose during the first 4 h after induction of AMI." -circulation_biomarker_diagnosis_ns hsa-mir-208a Myocardial Infarction 23747779 "Circulating miR-1, miR-208a, and miR-133a continuously rose during the first 4 h after induction of AMI." -circulation_biomarker_diagnosis_ns hsa-mir-155 Breast Neoplasms 23748853 "Deregulated Serum Concentrations of Circulating Cell-Free MicroRNAs miR-17, miR-34a, miR-155, and miR-373 in Human Breast Cancer Development and Progression." -circulation_biomarker_diagnosis_ns hsa-mir-17 Breast Neoplasms 23748853 "Deregulated Serum Concentrations of Circulating Cell-Free MicroRNAs miR-17, miR-34a, miR-155, and miR-373 in Human Breast Cancer Development and Progression." -circulation_biomarker_diagnosis_ns hsa-mir-34a Breast Neoplasms 23748853 "Deregulated Serum Concentrations of Circulating Cell-Free MicroRNAs miR-17, miR-34a, miR-155, and miR-373 in Human Breast Cancer Development and Progression." -circulation_biomarker_diagnosis_ns hsa-mir-373 Breast Neoplasms 23748853 "Deregulated Serum Concentrations of Circulating Cell-Free MicroRNAs miR-17, miR-34a, miR-155, and miR-373 in Human Breast Cancer Development and Progression." -circulation_biomarker_diagnosis_ns hsa-mir-10a "Carcinoma, Lung, Non-Small-Cell" 23756108 "Plasma miR-21, miR-30d, miR-451, miR-10a, miR-30e-5p and miR-126*, miR-126, miR-145) were differentially expressed" -circulation_biomarker_diagnosis_ns hsa-mir-126 "Carcinoma, Lung, Non-Small-Cell" 23756108 "Plasma miR-21, miR-30d, miR-451, miR-10a, miR-30e-5p and miR-126*, miR-126, miR-145) were differentially expressed" -circulation_biomarker_diagnosis_ns hsa-mir-145 "Carcinoma, Lung, Non-Small-Cell" 23756108 "Plasma miR-21, miR-30d, miR-451, miR-10a, miR-30e-5p and miR-126*, miR-126, miR-145) were differentially expressed" -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 23756108 "Plasma miR-21, miR-30d, miR-451, miR-10a, miR-30e-5p and miR-126*, miR-126, miR-145) were differentially expressed" -circulation_biomarker_diagnosis_ns hsa-mir-30d "Carcinoma, Lung, Non-Small-Cell" 23756108 "Plasma miR-21, miR-30d, miR-451, miR-10a, miR-30e-5p and miR-126*, miR-126, miR-145) were differentially expressed" -circulation_biomarker_diagnosis_ns hsa-mir-30e "Carcinoma, Lung, Non-Small-Cell" 23756108 "Plasma miR-21, miR-30d, miR-451, miR-10a, miR-30e-5p and miR-126*, miR-126, miR-145) were differentially expressed" -circulation_biomarker_diagnosis_ns hsa-mir-451a "Carcinoma, Lung, Non-Small-Cell" 23756108 "Plasma miR-21, miR-30d, miR-451, miR-10a, miR-30e-5p and miR-126*, miR-126, miR-145) were differentially expressed" -circulation_biomarker_diagnosis_ns hsa-mir-451b "Carcinoma, Lung, Non-Small-Cell" 23756108 "Plasma miR-21, miR-30d, miR-451, miR-10a, miR-30e-5p and miR-126*, miR-126, miR-145) were differentially expressed" -circulation_biomarker_diagnosis_ns hsa-mir-195 "Carcinoma, Adrenocortical" 23756429 Serum miR-483-5p and miR-195 are predictive of recurrence risk in adrenocortical cancer patients. -circulation_biomarker_diagnosis_ns hsa-mir-483 "Carcinoma, Adrenocortical" 23756429 Serum miR-483-5p and miR-195 are predictive of recurrence risk in adrenocortical cancer patients. -circulation_biomarker_diagnosis_ns hsa-mir-145 Multiple Sclerosis 23773985 "RRMS patients in remission had altered expression of mirNAs. We validated mir-145 as a potential diagnostic biomarker for the diagnosis of MS in blood, plasma and serum." -circulation_biomarker_diagnosis_ns hsa-mir-27a Pancreatic Neoplasms 23782250 Combined serum CA19-9 and miR-27a-3p in peripheral blood mononuclear cells to diagnose pancreatic cancer. -circulation_biomarker_diagnosis_ns hsa-mir-424 Fragile X Syndrome 23790110 MicroRNA expression profiling in blood from fragile X-associated tremor/ataxia syndrome patients. -circulation_biomarker_diagnosis_ns hsa-mir-574 Fragile X Syndrome 23790110 MicroRNA expression profiling in blood from fragile X-associated tremor/ataxia syndrome patients. -circulation_biomarker_diagnosis_ns hsa-mir-1246 Early-Stage Cervical Squamous Cell Carcinoma 23799609 Serum microRNA expression levels can predict lymph node metastasis in patients with early-stage cervical squamous cell carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-20a Early-Stage Cervical Squamous Cell Carcinoma 23799609 Serum microRNA expression levels can predict lymph node metastasis in patients with early-stage cervical squamous cell carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-2392 Early-Stage Cervical Squamous Cell Carcinoma 23799609 Serum microRNA expression levels can predict lymph node metastasis in patients with early-stage cervical squamous cell carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-3162 Early-Stage Cervical Squamous Cell Carcinoma 23799609 Serum microRNA expression levels can predict lymph node metastasis in patients with early-stage cervical squamous cell carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-4484 Early-Stage Cervical Squamous Cell Carcinoma 23799609 Serum microRNA expression levels can predict lymph node metastasis in patients with early-stage cervical squamous cell carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-106b Gastric Neoplasms 23806809 Validation of circulating miRNA biomarkers for predicting lymph node metastasis in gastric cancer. -circulation_biomarker_diagnosis_ns hsa-mir-146a Gastric Neoplasms 23806809 Validation of circulating miRNA biomarkers for predicting lymph node metastasis in gastric cancer. -circulation_biomarker_diagnosis_ns hsa-mir-148a Gastric Neoplasms 23806809 Validation of circulating miRNA biomarkers for predicting lymph node metastasis in gastric cancer. -circulation_biomarker_diagnosis_ns hsa-mir-21 Gastric Neoplasms 23806809 Validation of circulating miRNA biomarkers for predicting lymph node metastasis in gastric cancer. -circulation_biomarker_diagnosis_ns hsa-mir-223 Gastric Neoplasms 23806809 Validation of circulating miRNA biomarkers for predicting lymph node metastasis in gastric cancer. -circulation_biomarker_diagnosis_ns hsa-mir-27a Gastric Neoplasms 23806809 Validation of circulating miRNA biomarkers for predicting lymph node metastasis in gastric cancer. -circulation_biomarker_diagnosis_ns hsa-mir-433 Gastric Neoplasms 23806809 Validation of circulating miRNA biomarkers for predicting lymph node metastasis in gastric cancer. -circulation_biomarker_diagnosis_ns hsa-mir-1 "Carcinoma, Hepatocellular" 23810247 Our data indicate that serum miR-1 is a new independent parameter of OS in HCC patients and may therefore improve the predictive value of classical HCC staging scores. -circulation_biomarker_diagnosis_ns hsa-mir-122 "Carcinoma, Hepatocellular" 23810247 Our data indicate that serum miR-1 is a new independent parameter of OS in HCC patients and may therefore improve the predictive value of classical HCC staging scores. -circulation_biomarker_diagnosis_ns hsa-mir-122 Chronic Obstructive Pulmonary Disease 23814167 Plasma levels of individual myomiRs are altered in patients with COPD but alone do not predict muscle fibre size or proportion. Our findings are consistent with an increase in muscle wasting and turnover associated with the development of skeletal muscle dysfunction and fibre-type shift in patients with stable COPD. -circulation_biomarker_diagnosis_ns hsa-mir-16 Chronic Obstructive Pulmonary Disease 23814167 Plasma levels of individual myomiRs are altered in patients with COPD but alone do not predict muscle fibre size or proportion. Our findings are consistent with an increase in muscle wasting and turnover associated with the development of skeletal muscle dysfunction and fibre-type shift in patients with stable COPD. -circulation_biomarker_diagnosis_ns hsa-mir-107 Pancreatic Neoplasms 23834149 "At last, we have also explained the role of miRNAs in diagnostic marker (miR- 200, miR-21, miR-103, miR-107, and miR-155) and as a therapeutic modulator (miR-34, miR-21, miR-221, and miR-101) in pancreatic cancer." -circulation_biomarker_diagnosis_ns hsa-mir-29c Colorectal Carcinoma 23840538 "miRNA-29c shows anti-tumorigenesis activity, and preoperative circulating miRNA-29c levels can be used to predict postoperative early relapse of CRC." -circulation_biomarker_diagnosis_ns hsa-mir-145 Stroke 23860376 Serum miR-145 was not detected in over 50% of the patients and it may not be an ideal marker to predict stroke. MiR-21 and miR-221 are novel biomarkers for atherosclerosis and stroke. -circulation_biomarker_diagnosis_ns hsa-mir-221 Stroke 23860376 Serum miR-145 was not detected in over 50% of the patients and it may not be an ideal marker to predict stroke. MiR-21 and miR-221 are novel biomarkers for atherosclerosis and stroke. -circulation_biomarker_diagnosis_ns hsa-mir-145 Melanoma 23863473 Sensitive detection of melanoma metastasis using circulating microRNA expression profiles. -circulation_biomarker_diagnosis_ns hsa-mir-150 Melanoma 23863473 Sensitive detection of melanoma metastasis using circulating microRNA expression profiles. -circulation_biomarker_diagnosis_ns hsa-mir-155 Melanoma 23863473 Sensitive detection of melanoma metastasis using circulating microRNA expression profiles. -circulation_biomarker_diagnosis_ns hsa-mir-203 Melanoma 23863473 Sensitive detection of melanoma metastasis using circulating microRNA expression profiles. -circulation_biomarker_diagnosis_ns hsa-mir-205 Melanoma 23863473 Sensitive detection of melanoma metastasis using circulating microRNA expression profiles. -circulation_biomarker_diagnosis_ns hsa-mir-9 Melanoma 23863473 Sensitive detection of melanoma metastasis using circulating microRNA expression profiles. -circulation_biomarker_diagnosis_ns hsa-mir-130b Metabolic Syndrome 23868745 Circulating miR-130b reflects the degree of obesity and could serve as a potential biomarker for hypertriacylglycerolaemia and metabolic syndrome. Circulating miR-130b could function as a metabolic mediator for adipose muscle crosstalk and might be involved in the pathogenesis of obesity associated metabolic diseases. -circulation_biomarker_diagnosis_ns hsa-mir-106b Neoplasms [unspecific] 23874370 Principal component analysis based feature extraction approach to identify circulating microRNA biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-140 Neoplasms [unspecific] 23874370 Principal component analysis based feature extraction approach to identify circulating microRNA biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-15b Neoplasms [unspecific] 23874370 Principal component analysis based feature extraction approach to identify circulating microRNA biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-16 Neoplasms [unspecific] 23874370 Principal component analysis based feature extraction approach to identify circulating microRNA biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-185 Neoplasms [unspecific] 23874370 Principal component analysis based feature extraction approach to identify circulating microRNA biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-191 Neoplasms [unspecific] 23874370 Principal component analysis based feature extraction approach to identify circulating microRNA biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-19b Neoplasms [unspecific] 23874370 Principal component analysis based feature extraction approach to identify circulating microRNA biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-30d Neoplasms [unspecific] 23874370 Principal component analysis based feature extraction approach to identify circulating microRNA biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-320a Neoplasms [unspecific] 23874370 Principal component analysis based feature extraction approach to identify circulating microRNA biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-425 Neoplasms [unspecific] 23874370 Principal component analysis based feature extraction approach to identify circulating microRNA biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-486 Neoplasms [unspecific] 23874370 Principal component analysis based feature extraction approach to identify circulating microRNA biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-92a Neoplasms [unspecific] 23874370 Principal component analysis based feature extraction approach to identify circulating microRNA biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-125a Rheumatoid Arthritis 23874885 Comprehensive microRNA analysis identifies miR-24 and miR-125a-5p as plasma biomarkers for rheumatoid arthritis. -circulation_biomarker_diagnosis_ns hsa-mir-24 Rheumatoid Arthritis 23874885 Comprehensive microRNA analysis identifies miR-24 and miR-125a-5p as plasma biomarkers for rheumatoid arthritis. -circulation_biomarker_diagnosis_ns hsa-mir-125b Machado-Joseph Disease 23879331 MicroRNA profiling in the serums of SCA3/MJD patients. -circulation_biomarker_diagnosis_ns hsa-mir-25 Machado-Joseph Disease 23879331 MicroRNA profiling in the serums of SCA3/MJD patients. -circulation_biomarker_diagnosis_ns hsa-mir-29a Machado-Joseph Disease 23879331 MicroRNA profiling in the serums of SCA3/MJD patients. -circulation_biomarker_diagnosis_ns hsa-mir-34b Machado-Joseph Disease 23879331 MicroRNA profiling in the serums of SCA3/MJD patients. -circulation_biomarker_diagnosis_ns hsa-mir-205 "Carcinoma, Lung, Non-Small-Cell" 23881177 "Relative expressions of miR-205-5p, miR-205-3p, and miR-21 in tissues and serum of non-small cell lung cancer patients." -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 23881177 "Relative expressions of miR-205-5p, miR-205-3p, and miR-21 in tissues and serum of non-small cell lung cancer patients." -circulation_biomarker_diagnosis_ns hsa-mir-16 Liver Diseases [unspecific] 23886700 Incubation of whole blood at room temperature does not alter the plasma concentrations of microRNA-16 and -223. -circulation_biomarker_diagnosis_ns hsa-mir-223 Liver Diseases [unspecific] 23886700 Incubation of whole blood at room temperature does not alter the plasma concentrations of microRNA-16 and -223. -circulation_biomarker_diagnosis_ns hsa-let-7d Alzheimer Disease 23922807 Circulating miRNA biomarkers for Alzheimer's disease. -circulation_biomarker_diagnosis_ns hsa-let-7g Alzheimer Disease 23922807 Circulating miRNA biomarkers for Alzheimer's disease. -circulation_biomarker_diagnosis_ns hsa-mir-142 Alzheimer Disease 23922807 Circulating miRNA biomarkers for Alzheimer's disease. -circulation_biomarker_diagnosis_ns hsa-mir-15b Alzheimer Disease 23922807 Circulating miRNA biomarkers for Alzheimer's disease. -circulation_biomarker_diagnosis_ns hsa-mir-191 Alzheimer Disease 23922807 Circulating miRNA biomarkers for Alzheimer's disease. -circulation_biomarker_diagnosis_ns hsa-mir-301a Alzheimer Disease 23922807 Circulating miRNA biomarkers for Alzheimer's disease. -circulation_biomarker_diagnosis_ns hsa-mir-545 Alzheimer Disease 23922807 Circulating miRNA biomarkers for Alzheimer's disease. -circulation_biomarker_diagnosis_ns hsa-mir-122 Metabolic Syndrome 23922812 These findings cast new light on the regulation of miR-33a and miR-122 in a dyslipidemic model of obese rats and the way these miRNAs are modulated by dietary components in the liver and in PBMCs. -circulation_biomarker_diagnosis_ns hsa-mir-33a Metabolic Syndrome 23922812 These findings cast new light on the regulation of miR-33a and miR-122 in a dyslipidemic model of obese rats and the way these miRNAs are modulated by dietary components in the liver and in PBMCs. -circulation_biomarker_diagnosis_ns hsa-mir-141 Prostate Neoplasms 23935962 Circulating microRNA profiling identifies a subset of metastatic prostate cancer patients with evidence of cancer-associated hypoxia. -circulation_biomarker_diagnosis_ns hsa-mir-200a Prostate Neoplasms 23935962 Circulating microRNA profiling identifies a subset of metastatic prostate cancer patients with evidence of cancer-associated hypoxia. -circulation_biomarker_diagnosis_ns hsa-mir-200c Prostate Neoplasms 23935962 Circulating microRNA profiling identifies a subset of metastatic prostate cancer patients with evidence of cancer-associated hypoxia. -circulation_biomarker_diagnosis_ns hsa-mir-210 Prostate Neoplasms 23935962 Circulating microRNA profiling identifies a subset of metastatic prostate cancer patients with evidence of cancer-associated hypoxia. -circulation_biomarker_diagnosis_ns hsa-mir-375 Prostate Neoplasms 23935962 Circulating microRNA profiling identifies a subset of metastatic prostate cancer patients with evidence of cancer-associated hypoxia. -circulation_biomarker_diagnosis_ns hsa-mir-124 Glioma 23936026 These results suggest that miR-124 may function as anti-migration and anti-invasion influence in glioma and provides a potential approach for developing miR-124-based therapeutic strategies for malignant glioma therapy. -circulation_biomarker_diagnosis_ns hsa-mir-133a Aortic Stenosis 23948643 "Preoperative plasma levels of miR-133a reflect their myocardial pression and predict the regression potential of LV hypertrophy after AVR. The value of this bedside information for the surgical timing, particularly in asymptomatic aortic stenosis patients, deserves confirmation in further clinical studies." -circulation_biomarker_diagnosis_ns hsa-mir-92 Ovary Mixed Epithelial Carcinoma 23963852 The detection of miR-92 levels in the serum might serve as a new tumour biomarker in the diagnosis and assessment of prognosis of EOC. -circulation_biomarker_diagnosis_ns hsa-mir-193b Leukemia 23998571 MicroRNA-193b expression in newly diagnosed leukemia patients and its significance. -circulation_biomarker_diagnosis_ns hsa-mir-139 Colorectal Carcinoma 24022433 "Plasma miRNAs are reliable, noninvasive, and inexpensive markers for CR adenomas. This miRNA panel warrants study in larger cohorts. Plasma-based assays could provide better screening compliance compared to fecal occult blood or endoscopic screening." -circulation_biomarker_diagnosis_ns hsa-mir-142 Colorectal Carcinoma 24022433 "Plasma miRNAs are reliable, noninvasive, and inexpensive markers for CR adenomas. This miRNA panel warrants study in larger cohorts. Plasma-based assays could provide better screening compliance compared to fecal occult blood or endoscopic screening." -circulation_biomarker_diagnosis_ns hsa-mir-15b Colorectal Carcinoma 24022433 "Plasma miRNAs are reliable, noninvasive, and inexpensive markers for CR adenomas. This miRNA panel warrants study in larger cohorts. Plasma-based assays could provide better screening compliance compared to fecal occult blood or endoscopic screening." -circulation_biomarker_diagnosis_ns hsa-mir-431 Colorectal Carcinoma 24022433 "Plasma miRNAs are reliable, noninvasive, and inexpensive markers for CR adenomas. This miRNA panel warrants study in larger cohorts. Plasma-based assays could provide better screening compliance compared to fecal occult blood or endoscopic screening." -circulation_biomarker_diagnosis_ns hsa-mir-532 Colorectal Carcinoma 24022433 "Plasma miRNAs are reliable, noninvasive, and inexpensive markers for CR adenomas. This miRNA panel warrants study in larger cohorts. Plasma-based assays could provide better screening compliance compared to fecal occult blood or endoscopic screening." -circulation_biomarker_diagnosis_ns hsa-mir-652 Colorectal Carcinoma 24022433 "Plasma miRNAs are reliable, noninvasive, and inexpensive markers for CR adenomas. This miRNA panel warrants study in larger cohorts. Plasma-based assays could provide better screening compliance compared to fecal occult blood or endoscopic screening." -circulation_biomarker_diagnosis_ns hsa-mir-16 "Carcinoma, Nasopharyngeal" 24025417 "plasma miRNA expression is a useful biomarker for NPC diagnosis but not for its prognosis. More importantly, it is simple, effective, and non-invasive. Combination of several plasma miRNAs can increase both NPC diagnostic sensitivity and specificity. miR-329,hsa-mir-487b,hsa-mir-494,hsa-mir-495" -circulation_biomarker_diagnosis_ns hsa-mir-210 Preeclampsia 24035613 "Hence, we conclude that aberrant expression of miR-210 may contribute to trophoblast function and that miR-210 is a novel predictive serum biomarker for preeclampsia that can help in identifying at-risk women for monitoring and treatment." -circulation_biomarker_diagnosis_ns hsa-mir-155 Graft-Versus-Host Disease 24041574 Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease. -circulation_biomarker_diagnosis_ns hsa-mir-199a Graft-Versus-Host Disease 24041574 Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease. -circulation_biomarker_diagnosis_ns hsa-mir-30a Graft-Versus-Host Disease 24041574 Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease. -circulation_biomarker_diagnosis_ns hsa-mir-377 Graft-Versus-Host Disease 24041574 Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease. -circulation_biomarker_diagnosis_ns hsa-mir-423 Graft-Versus-Host Disease 24041574 Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease. -circulation_biomarker_diagnosis_ns hsa-mir-93 Graft-Versus-Host Disease 24041574 Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease. -circulation_biomarker_diagnosis_ns hsa-mir-133a Acute Myocardial Infarction 24053180 Circulating miR-133a may be a new biomarker for AMI and as a potential diagnostic tool. And increased miR-133a level may be used to predict both the presence and severity of coronary lesions in CHD patients. -circulation_biomarker_diagnosis_ns hsa-mir-210 "Carcinoma, Lung, Non-Small-Cell" 24065453 These findings suggest that serum miR-210 levels might be a novel diagnostic and prognostic marker of NSCLC. -circulation_biomarker_diagnosis_ns hsa-mir-135a "Leukemia, Myeloid, Acute" 24072101 "miR-409-3p, miR-135a, miR-196b and mir-644 arose as prognostic markers for IR-AML, both overall and within specific molecular subgroups." -circulation_biomarker_diagnosis_ns hsa-mir-196b "Leukemia, Myeloid, Acute" 24072101 "miR-409-3p, miR-135a, miR-196b and mir-644 arose as prognostic markers for IR-AML, both overall and within specific molecular subgroups." -circulation_biomarker_diagnosis_ns hsa-mir-409 "Leukemia, Myeloid, Acute" 24072101 "miR-409-3p, miR-135a, miR-196b and mir-644 arose as prognostic markers for IR-AML, both overall and within specific molecular subgroups." -circulation_biomarker_diagnosis_ns hsa-mir-644 "Leukemia, Myeloid, Acute" 24072101 "miR-409-3p, miR-135a, miR-196b and mir-644 arose as prognostic markers for IR-AML, both overall and within specific molecular subgroups." -circulation_biomarker_diagnosis_ns hsa-mir-122 Liver Injury 24086271 "serum miR-122 has strong potential as a novel, specific and noninvasive biomarker for diagnosis of cholestasis-induced liver injury." -circulation_biomarker_diagnosis_ns hsa-mir-21 Biliary Tract Neoplasms 24118467 "Plasma miR-21 is a novel diagnostic biomarker for BTC, and may be useful in distinguishing between BTC and BBD patients." -circulation_biomarker_diagnosis_ns hsa-mir-15b Peripheral Vascular Disease 24129591 "A 12-miRNA PAD-specific signature, which includes let 7e, miR-15b, -16, -20b, -25, -26b,-27b, -28-5p, -126, -195, -335, and -363, was further investigated and validated in 2 additional sample sets. Each of these 12 miRNAs exhibited good diagnostic value as evidenced by receiver operating characteristic curve analyses.miR-16, miR-363, and miR-15b had the best predictive values" -circulation_biomarker_diagnosis_ns hsa-mir-16 Peripheral Vascular Disease 24129591 "A 12-miRNA PAD-specific signature, which includes let 7e, miR-15b, -16, -20b, -25, -26b,-27b, -28-5p, -126, -195, -335, and -363, was further investigated and validated in 2 additional sample sets. Each of these 12 miRNAs exhibited good diagnostic value as evidenced by receiver operating characteristic curve analyses.miR-16, miR-363, and miR-15b had the best predictive values" -circulation_biomarker_diagnosis_ns hsa-mir-363 Peripheral Vascular Disease 24129591 "A 12-miRNA PAD-specific signature, which includes let 7e, miR-15b, -16, -20b, -25, -26b,-27b, -28-5p, -126, -195, -335, and -363, was further investigated and validated in 2 additional sample sets. Each of these 12 miRNAs exhibited good diagnostic value as evidenced by receiver operating characteristic curve analyses.miR-16, miR-363, and miR-15b had the best predictive values" -circulation_biomarker_diagnosis_ns hsa-mir-126 Peripheral Vascular Disease 24129592 "A 12-miRNA PAD-specific signature, which includes let 7e, miR-15b, -16, -20b, -25, -26b,-27b, -28-5p, -126, -195, -335, and -363, was further investigated and validated in 2 additional sample sets. Each of these 12 miRNAs exhibited good diagnostic value as evidenced by receiver operating characteristic curve analyses." -circulation_biomarker_diagnosis_ns hsa-mir-15b Peripheral Vascular Disease 24129592 "A 12-miRNA PAD-specific signature, which includes let 7e, miR-15b, -16, -20b, -25, -26b,-27b, -28-5p, -126, -195, -335, and -363, was further investigated and validated in 2 additional sample sets. Each of these 12 miRNAs exhibited good diagnostic value as evidenced by receiver operating characteristic curve analyses." -circulation_biomarker_diagnosis_ns hsa-mir-16 Peripheral Vascular Disease 24129592 "A 12-miRNA PAD-specific signature, which includes let 7e, miR-15b, -16, -20b, -25, -26b,-27b, -28-5p, -126, -195, -335, and -363, was further investigated and validated in 2 additional sample sets. Each of these 12 miRNAs exhibited good diagnostic value as evidenced by receiver operating characteristic curve analyses." -circulation_biomarker_diagnosis_ns hsa-mir-181a-2 Peripheral Vascular Disease 24129592 "A 12-miRNA PAD-specific signature, which includes let 7e, miR-15b, -16, -20b, -25, -26b,-27b, -28-5p, -126, -195, -335, and -363, was further investigated and validated in 2 additional sample sets. Each of these 12 miRNAs exhibited good diagnostic value as evidenced by receiver operating characteristic curve analyses." -circulation_biomarker_diagnosis_ns hsa-mir-195 Peripheral Vascular Disease 24129592 "A 12-miRNA PAD-specific signature, which includes let 7e, miR-15b, -16, -20b, -25, -26b,-27b, -28-5p, -126, -195, -335, and -363, was further investigated and validated in 2 additional sample sets. Each of these 12 miRNAs exhibited good diagnostic value as evidenced by receiver operating characteristic curve analyses." -circulation_biomarker_diagnosis_ns hsa-mir-20b Peripheral Vascular Disease 24129592 "A 12-miRNA PAD-specific signature, which includes let 7e, miR-15b, -16, -20b, -25, -26b,-27b, -28-5p, -126, -195, -335, and -363, was further investigated and validated in 2 additional sample sets. Each of these 12 miRNAs exhibited good diagnostic value as evidenced by receiver operating characteristic curve analyses." -circulation_biomarker_diagnosis_ns hsa-mir-25 Peripheral Vascular Disease 24129592 "A 12-miRNA PAD-specific signature, which includes let 7e, miR-15b, -16, -20b, -25, -26b,-27b, -28-5p, -126, -195, -335, and -363, was further investigated and validated in 2 additional sample sets. Each of these 12 miRNAs exhibited good diagnostic value as evidenced by receiver operating characteristic curve analyses." -circulation_biomarker_diagnosis_ns hsa-mir-26b Peripheral Vascular Disease 24129592 "A 12-miRNA PAD-specific signature, which includes let 7e, miR-15b, -16, -20b, -25, -26b,-27b, -28-5p, -126, -195, -335, and -363, was further investigated and validated in 2 additional sample sets. Each of these 12 miRNAs exhibited good diagnostic value as evidenced by receiver operating characteristic curve analyses." -circulation_biomarker_diagnosis_ns hsa-mir-27b Peripheral Vascular Disease 24129592 "A 12-miRNA PAD-specific signature, which includes let 7e, miR-15b, -16, -20b, -25, -26b,-27b, -28-5p, -126, -195, -335, and -363, was further investigated and validated in 2 additional sample sets. Each of these 12 miRNAs exhibited good diagnostic value as evidenced by receiver operating characteristic curve analyses." -circulation_biomarker_diagnosis_ns hsa-mir-28 Peripheral Vascular Disease 24129592 "A 12-miRNA PAD-specific signature, which includes let 7e, miR-15b, -16, -20b, -25, -26b,-27b, -28-5p, -126, -195, -335, and -363, was further investigated and validated in 2 additional sample sets. Each of these 12 miRNAs exhibited good diagnostic value as evidenced by receiver operating characteristic curve analyses." -circulation_biomarker_diagnosis_ns hsa-mir-335 Peripheral Vascular Disease 24129592 "A 12-miRNA PAD-specific signature, which includes let 7e, miR-15b, -16, -20b, -25, -26b,-27b, -28-5p, -126, -195, -335, and -363, was further investigated and validated in 2 additional sample sets. Each of these 12 miRNAs exhibited good diagnostic value as evidenced by receiver operating characteristic curve analyses." -circulation_biomarker_diagnosis_ns hsa-mir-363 Peripheral Vascular Disease 24129592 "A 12-miRNA PAD-specific signature, which includes let 7e, miR-15b, -16, -20b, -25, -26b,-27b, -28-5p, -126, -195, -335, and -363, was further investigated and validated in 2 additional sample sets. Each of these 12 miRNAs exhibited good diagnostic value as evidenced by receiver operating characteristic curve analyses." -circulation_biomarker_diagnosis_ns hsa-mir-423 Hereditary Breast Carcinoma 24129975 miR-4417 and miR-423-3p expressions differentiated 70.1 % of hereditary and non-hereditary BCs. Array miR expression profiles can differentiate the four study groups using FFPE BC. -circulation_biomarker_diagnosis_ns hsa-mir-4417 Hereditary Breast Carcinoma 24129975 miR-4417 and miR-423-3p expressions differentiated 70.1 % of hereditary and non-hereditary BCs. Array miR expression profiles can differentiate the four study groups using FFPE BC. -circulation_biomarker_diagnosis_ns hsa-mir-19a "Squamous Cell Carcinoma, Lung" 24130905 "Tumor cells secrete miRNA-containing exosomes into circulation, and that miRNA profiling of the exosomal plasma fraction may reveal powerful cancer biomarkers." -circulation_biomarker_diagnosis_ns hsa-mir-19b "Squamous Cell Carcinoma, Lung" 24130905 "Tumor cells secrete miRNA-containing exosomes into circulation, and that miRNA profiling of the exosomal plasma fraction may reveal powerful cancer biomarkers." -circulation_biomarker_diagnosis_ns hsa-mir-205 "Squamous Cell Carcinoma, Lung" 24130905 "Tumor cells secrete miRNA-containing exosomes into circulation, and that miRNA profiling of the exosomal plasma fraction may reveal powerful cancer biomarkers." -circulation_biomarker_diagnosis_ns hsa-mir-20a "Squamous Cell Carcinoma, Lung" 24130905 "Tumor cells secrete miRNA-containing exosomes into circulation, and that miRNA profiling of the exosomal plasma fraction may reveal powerful cancer biomarkers." -circulation_biomarker_diagnosis_ns hsa-mir-30b "Squamous Cell Carcinoma, Lung" 24130905 "Tumor cells secrete miRNA-containing exosomes into circulation, and that miRNA profiling of the exosomal plasma fraction may reveal powerful cancer biomarkers." -circulation_biomarker_diagnosis_ns hsa-mir-125b Alzheimer Disease 24139697 Our results indicate that serum miR-125b may serve as a useful noninvasive biomarker for AD. -circulation_biomarker_diagnosis_ns hsa-mir-150 Sepsis 24146790 microRNA miR-150 and miR-4772-5p-iso were able to discriminate between patients who have systemic inflammatory response syndrome and patients with sepsis. -circulation_biomarker_diagnosis_ns hsa-mir-24 Leukemia 24153013 "Altered expression of miR-24, miR-126 and miR-365 does not affect viability of childhood TCF3-rearranged leukemia cells." -circulation_biomarker_diagnosis_ns hsa-mir-365 Leukemia 24153013 "Altered expression of miR-24, miR-126 and miR-365 does not affect viability of childhood TCF3-rearranged leukemia cells." -circulation_biomarker_diagnosis_ns hsa-mir-127 Breast Neoplasms 24194846 Plasma microRNA panel for minimally invasive detection of breast cancer. -circulation_biomarker_diagnosis_ns hsa-mir-148b Breast Neoplasms 24194846 Plasma microRNA panel for minimally invasive detection of breast cancer. -circulation_biomarker_diagnosis_ns hsa-mir-376a Breast Neoplasms 24194846 Plasma microRNA panel for minimally invasive detection of breast cancer. -circulation_biomarker_diagnosis_ns hsa-mir-376c Breast Neoplasms 24194846 Plasma microRNA panel for minimally invasive detection of breast cancer. -circulation_biomarker_diagnosis_ns hsa-mir-409 Breast Neoplasms 24194846 Plasma microRNA panel for minimally invasive detection of breast cancer. -circulation_biomarker_diagnosis_ns hsa-mir-652 Breast Neoplasms 24194846 Plasma microRNA panel for minimally invasive detection of breast cancer. -circulation_biomarker_diagnosis_ns hsa-mir-801 Breast Neoplasms 24194846 Plasma microRNA panel for minimally invasive detection of breast cancer. -circulation_biomarker_diagnosis_ns hsa-mir-138 "Diabetes Mellitus, Type 2" 24204780 "This study is the first to show a panel of serum miRNAs for obesity, and compare them with miRNAs identified in serum for diabetes and obesity with diabetes. Our results support the use of some miRNAs extracted from serum samples as potential predictive tools for obesity and type 2 diabetes." -circulation_biomarker_diagnosis_ns hsa-mir-15b "Diabetes Mellitus, Type 2" 24204780 "This study is the first to show a panel of serum miRNAs for obesity, and compare them with miRNAs identified in serum for diabetes and obesity with diabetes. Our results support the use of some miRNAs extracted from serum samples as potential predictive tools for obesity and type 2 diabetes." -circulation_biomarker_diagnosis_ns hsa-mir-376a "Diabetes Mellitus, Type 2" 24204780 "This study is the first to show a panel of serum miRNAs for obesity, and compare them with miRNAs identified in serum for diabetes and obesity with diabetes. Our results support the use of some miRNAs extracted from serum samples as potential predictive tools for obesity and type 2 diabetes." -circulation_biomarker_diagnosis_ns hsa-mir-503 "Diabetes Mellitus, Type 2" 24204780 "This study is the first to show a panel of serum miRNAs for obesity, and compare them with miRNAs identified in serum for diabetes and obesity with diabetes. Our results support the use of some miRNAs extracted from serum samples as potential predictive tools for obesity and type 2 diabetes." -circulation_biomarker_diagnosis_ns hsa-mir-210 "Carcinoma, Renal Cell, Clear-Cell" 24212760 Serum miR-210 as a potential biomarker of early clear cell renal cell carcinoma. -circulation_biomarker_diagnosis_ns hsa-let-7b "Stroke, Ischemic" 24237608 "These data suggest that miR-30a, miR-126 and let-7b might be useful biomarkers for ischemic stroke in humans." -circulation_biomarker_diagnosis_ns hsa-mir-126 "Stroke, Ischemic" 24237608 "These data suggest that miR-30a, miR-126 and let-7b might be useful biomarkers for ischemic stroke in humans." -circulation_biomarker_diagnosis_ns hsa-mir-30a "Stroke, Ischemic" 24237608 "These data suggest that miR-30a, miR-126 and let-7b might be useful biomarkers for ischemic stroke in humans." -circulation_biomarker_diagnosis_ns hsa-mir-34a "Carcinoma, Adrenocortical" 24238045 We show that dysregulated miRNAs in ACC are detectable in human serum samples. MiR-34a and miR-483-5p are candidate serum biomarkers for distinguishing between benign and malignant adrenocortical tumors. -circulation_biomarker_diagnosis_ns hsa-mir-483 "Carcinoma, Adrenocortical" 24238045 We show that dysregulated miRNAs in ACC are detectable in human serum samples. MiR-34a and miR-483-5p are candidate serum biomarkers for distinguishing between benign and malignant adrenocortical tumors. -circulation_biomarker_diagnosis_ns hsa-mir-1 Acute Myocardial Infarction 24253456 Early in acute myocardial infarction the expression of miR-423-5p in plasma is significantly increased with subsequent normalization within 6 hours.Potentially it is an early marker of myocardial necrosis. -circulation_biomarker_diagnosis_ns hsa-mir-195 "Adenocarcinoma, Lung" 24282590 "Plasma levels of miR-195 and miR-122 expression were also associated with overall survival in the patients, especially in those with advanced stage (HR=0.23, 95%CI:0.07-0.84; and HR=0.22, 95%CI:0.06-0.77) and EGFR mutation (HR=0.27, 95%CI:0.08-0.96; and HR=0.23, 95%CI=0.06-0.81)." -circulation_biomarker_diagnosis_ns hsa-let-7b Myocardial Infarction 24284400 "The circulating let-7b is suspected to be the biomarker of acute MI and let-7i, the biomarker of DCM." -circulation_biomarker_diagnosis_ns hsa-mir-122 Liver Injury 24287929 Plasma miR-122 expression is correlated with hepatectomy-induced liver injury in patients with HCC. Increase in miR-122 expression could be used as an index of such injury before and after hepatectomy in these patients. -circulation_biomarker_diagnosis_ns hsa-mir-146b "Carcinoma, Thyroid, Papillary" 24301304 This study demonstrated that tumor levels of miR-222 and miR-146b are associated with PTC recurrence and that miR-222 and miR-146b levels in the circulation correspond to the presence of PTC. The potential of these miRNAs as tumor biomarkers to improve patient stratification according to the risk of recurrence and as circulating biomarkers for PTC surveillance warrants further study. -circulation_biomarker_diagnosis_ns hsa-mir-222 "Carcinoma, Thyroid, Papillary" 24301304 This study demonstrated that tumor levels of miR-222 and miR-146b are associated with PTC recurrence and that miR-222 and miR-146b levels in the circulation correspond to the presence of PTC. The potential of these miRNAs as tumor biomarkers to improve patient stratification according to the risk of recurrence and as circulating biomarkers for PTC surveillance warrants further study. -circulation_biomarker_diagnosis_ns hsa-mir-122 HELLP Syndrome 24304191 "In our proof of principle study, we demonstrated that patients with HELLP syndrome showed alterations of serum miRNA expression patterns. Data analysis goes along with the hypothesis that HELLP syndrome is regarded to be a heterogeneous disease." -circulation_biomarker_diagnosis_ns hsa-mir-133a HELLP Syndrome 24304191 "In our proof of principle study, we demonstrated that patients with HELLP syndrome showed alterations of serum miRNA expression patterns. Data analysis goes along with the hypothesis that HELLP syndrome is regarded to be a heterogeneous disease." -circulation_biomarker_diagnosis_ns hsa-mir-758 HELLP Syndrome 24304191 "In our proof of principle study, we demonstrated that patients with HELLP syndrome showed alterations of serum miRNA expression patterns. Data analysis goes along with the hypothesis that HELLP syndrome is regarded to be a heterogeneous disease." -circulation_biomarker_diagnosis_ns hsa-mir-122 "Fatty Liver, Non-Alcoholic" 24313922 We found that the hepatic and serum miR-122 levels were associated with hepatic steatosis and fibrosis. The serum miR-122 level can be a useful predictive marker of liver fibrosis in patients with NAFLD. -circulation_biomarker_diagnosis_ns hsa-mir-9 "Carcinoma, Nasopharyngeal" 24327016 Our study reports that plasma miR-9 may serve as a useful biomarker to predict NPC metastasis and to monitor tumour dynamics. -circulation_biomarker_diagnosis_ns hsa-mir-100 Adrenal Cortex Neoplasms 24336071 "In contrast, of the selected eight miRNAs reported in the literature as differentially expressed in ACT tissues, five (hsa-miR-100, hsa-miR-181b, hsa-miR-184, hsa-miR-210 and hsa-miR-483-5p) showed a statistically significant overexpression in adrenocortical cancer vs adenoma when normalized on hsa-miR-16 as a reference gene." -circulation_biomarker_diagnosis_ns hsa-mir-210 Adrenal Cortex Neoplasms 24336071 "In contrast, of the selected eight miRNAs reported in the literature as differentially expressed in ACT tissues, five (hsa-miR-100, hsa-miR-181b, hsa-miR-184, hsa-miR-210 and hsa-miR-483-5p) showed a statistically significant overexpression in adrenocortical cancer vs adenoma when normalized on hsa-miR-16 as a reference gene." -circulation_biomarker_diagnosis_ns hsa-mir-128 Mild Cognitive Impairment 24368295 Plasma microRNA biomarkers for detection of mild cognitive impairment: biomarker validation study. -circulation_biomarker_diagnosis_ns hsa-mir-132 Mild Cognitive Impairment 24368295 Plasma microRNA biomarkers for detection of mild cognitive impairment: biomarker validation study. -circulation_biomarker_diagnosis_ns hsa-mir-134 Mild Cognitive Impairment 24368295 Plasma microRNA biomarkers for detection of mild cognitive impairment: biomarker validation study. -circulation_biomarker_diagnosis_ns hsa-mir-323 Mild Cognitive Impairment 24368295 Plasma microRNA biomarkers for detection of mild cognitive impairment: biomarker validation study. -circulation_biomarker_diagnosis_ns hsa-mir-370 Mild Cognitive Impairment 24368295 Plasma microRNA biomarkers for detection of mild cognitive impairment: biomarker validation study. -circulation_biomarker_diagnosis_ns hsa-mir-382 Mild Cognitive Impairment 24368295 Plasma microRNA biomarkers for detection of mild cognitive impairment: biomarker validation study. -circulation_biomarker_diagnosis_ns hsa-mir-491 Mild Cognitive Impairment 24368295 Plasma microRNA biomarkers for detection of mild cognitive impairment: biomarker validation study. -circulation_biomarker_diagnosis_ns hsa-mir-874 Mild Cognitive Impairment 24368295 Plasma microRNA biomarkers for detection of mild cognitive impairment: biomarker validation study. -circulation_biomarker_diagnosis_ns hsa-mir-125b Uveal Melanoma 24370793 The development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. These changes are associated with changes in plasma and cellular levels of immune regulatory miRs. The results may help guide uveal melanoma immunotherapy and biomarker development. -circulation_biomarker_diagnosis_ns hsa-mir-146a Uveal Melanoma 24370793 The development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. These changes are associated with changes in plasma and cellular levels of immune regulatory miRs. The results may help guide uveal melanoma immunotherapy and biomarker development. -circulation_biomarker_diagnosis_ns hsa-mir-155 Uveal Melanoma 24370793 The development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. These changes are associated with changes in plasma and cellular levels of immune regulatory miRs. The results may help guide uveal melanoma immunotherapy and biomarker development. -circulation_biomarker_diagnosis_ns hsa-mir-20a Uveal Melanoma 24370793 The development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. These changes are associated with changes in plasma and cellular levels of immune regulatory miRs. The results may help guide uveal melanoma immunotherapy and biomarker development. -circulation_biomarker_diagnosis_ns hsa-mir-223 Uveal Melanoma 24370793 The development of metastasis in uveal melanoma is associated with changes in immune effector and regulatory cells consistent with lessening tumor immune surveillance. These changes are associated with changes in plasma and cellular levels of immune regulatory miRs. The results may help guide uveal melanoma immunotherapy and biomarker development. -circulation_biomarker_diagnosis_ns hsa-mir-21 "Lymphoma, Large B-Cell, Diffuse" 24400911 Clinical significance and detection of microRNA-21 in serum of patients with diffuse large B-cell lymphoma in Chinese population. -circulation_biomarker_diagnosis_ns hsa-mir-133a Sepsis 24413579 Levels of circulating miR-133a are elevated in sepsis and predict mortality in critically ill patients. -circulation_biomarker_diagnosis_ns hsa-mir-223 Immune Thrombocytopenic Purpura 24418947 Plasma microRNA profiling of pediatric patients with immune thrombocytopenic purpura. -circulation_biomarker_diagnosis_ns hsa-mir-302a Immune Thrombocytopenic Purpura 24418947 Plasma microRNA profiling of pediatric patients with immune thrombocytopenic purpura. -circulation_biomarker_diagnosis_ns hsa-mir-302c Immune Thrombocytopenic Purpura 24418947 Plasma microRNA profiling of pediatric patients with immune thrombocytopenic purpura. -circulation_biomarker_diagnosis_ns hsa-mir-410 Immune Thrombocytopenic Purpura 24418947 Plasma microRNA profiling of pediatric patients with immune thrombocytopenic purpura. -circulation_biomarker_diagnosis_ns hsa-mir-483 Immune Thrombocytopenic Purpura 24418947 Plasma microRNA profiling of pediatric patients with immune thrombocytopenic purpura. -circulation_biomarker_diagnosis_ns hsa-mir-544a Immune Thrombocytopenic Purpura 24418947 Plasma microRNA profiling of pediatric patients with immune thrombocytopenic purpura. -circulation_biomarker_diagnosis_ns hsa-mir-597 Immune Thrombocytopenic Purpura 24418947 Plasma microRNA profiling of pediatric patients with immune thrombocytopenic purpura. -circulation_biomarker_diagnosis_ns hsa-mir-122 Sepsis 24421215 Serum miR-122 levels are related to coagulation disorders in sepsis patients. -circulation_biomarker_diagnosis_ns hsa-mir-378 Colorectal Carcinoma 24423916 "Plasma levels of miR-378 could be used to discriminate CRC patients from healthy individuals, irrespective of the level of haemoglobin of plasma samples." -circulation_biomarker_diagnosis_ns hsa-mir-122 Pancreatic Neoplasms 24449318 MicroRNA biomarkers in whole blood for detection of pancreatic cancer. -circulation_biomarker_diagnosis_ns hsa-mir-126 Pancreatic Neoplasms 24449318 MicroRNA biomarkers in whole blood for detection of pancreatic cancer. -circulation_biomarker_diagnosis_ns hsa-mir-145 Pancreatic Neoplasms 24449318 MicroRNA biomarkers in whole blood for detection of pancreatic cancer. -circulation_biomarker_diagnosis_ns hsa-mir-150 Pancreatic Neoplasms 24449318 MicroRNA biomarkers in whole blood for detection of pancreatic cancer. -circulation_biomarker_diagnosis_ns hsa-mir-223 Pancreatic Neoplasms 24449318 MicroRNA biomarkers in whole blood for detection of pancreatic cancer. -circulation_biomarker_diagnosis_ns hsa-mir-26b Pancreatic Neoplasms 24449318 MicroRNA biomarkers in whole blood for detection of pancreatic cancer. -circulation_biomarker_diagnosis_ns hsa-mir-34a Pancreatic Neoplasms 24449318 MicroRNA biomarkers in whole blood for detection of pancreatic cancer. -circulation_biomarker_diagnosis_ns hsa-mir-505 Pancreatic Neoplasms 24449318 MicroRNA biomarkers in whole blood for detection of pancreatic cancer. -circulation_biomarker_diagnosis_ns hsa-mir-636 Pancreatic Neoplasms 24449318 MicroRNA biomarkers in whole blood for detection of pancreatic cancer. -circulation_biomarker_diagnosis_ns hsa-mir-885 Pancreatic Neoplasms 24449318 MicroRNA biomarkers in whole blood for detection of pancreatic cancer. -circulation_biomarker_diagnosis_ns hsa-mir-186 "Squamous Cell Carcinoma, Oral" 24452363 "miR-186, miR-3651 and miR-494: potential biomarkers for oral squamous cell carcinoma extracted from whole blood." -circulation_biomarker_diagnosis_ns hsa-mir-3651 "Squamous Cell Carcinoma, Oral" 24452363 "miR-186, miR-3651 and miR-494: potential biomarkers for oral squamous cell carcinoma extracted from whole blood." -circulation_biomarker_diagnosis_ns hsa-mir-494 "Squamous Cell Carcinoma, Oral" 24452363 "miR-186, miR-3651 and miR-494: potential biomarkers for oral squamous cell carcinoma extracted from whole blood." -circulation_biomarker_diagnosis_ns hsa-mir-126 "Diabetes Mellitus, Type 2" 24455723 Plasma miR-126 is a potential biomarker for early prediction of type 2 diabetes mellitus in susceptible individuals. -circulation_biomarker_diagnosis_ns hsa-mir-1827 "Leukemia, Myeloid, Chronic" 24460325 Selective miRNA expression profile in chronic myeloid leukemia K562 cell-derived exosomes. -circulation_biomarker_diagnosis_ns hsa-mir-1973 "Leukemia, Myeloid, Chronic" 24460325 Selective miRNA expression profile in chronic myeloid leukemia K562 cell-derived exosomes. -circulation_biomarker_diagnosis_ns hsa-mir-298 "Leukemia, Myeloid, Chronic" 24460325 Selective miRNA expression profile in chronic myeloid leukemia K562 cell-derived exosomes. -circulation_biomarker_diagnosis_ns hsa-mir-299 "Leukemia, Myeloid, Chronic" 24460325 Selective miRNA expression profile in chronic myeloid leukemia K562 cell-derived exosomes. -circulation_biomarker_diagnosis_ns hsa-mir-3201 "Leukemia, Myeloid, Chronic" 24460325 Selective miRNA expression profile in chronic myeloid leukemia K562 cell-derived exosomes. -circulation_biomarker_diagnosis_ns hsa-mir-3611 "Leukemia, Myeloid, Chronic" 24460325 Selective miRNA expression profile in chronic myeloid leukemia K562 cell-derived exosomes. -circulation_biomarker_diagnosis_ns hsa-mir-3646 "Leukemia, Myeloid, Chronic" 24460325 Selective miRNA expression profile in chronic myeloid leukemia K562 cell-derived exosomes. -circulation_biomarker_diagnosis_ns hsa-mir-3686 "Leukemia, Myeloid, Chronic" 24460325 Selective miRNA expression profile in chronic myeloid leukemia K562 cell-derived exosomes. -circulation_biomarker_diagnosis_ns hsa-mir-3915 "Leukemia, Myeloid, Chronic" 24460325 Selective miRNA expression profile in chronic myeloid leukemia K562 cell-derived exosomes. -circulation_biomarker_diagnosis_ns hsa-mir-423 "Leukemia, Myeloid, Chronic" 24460325 Selective miRNA expression profile in chronic myeloid leukemia K562 cell-derived exosomes. -circulation_biomarker_diagnosis_ns hsa-mir-4268 "Leukemia, Myeloid, Chronic" 24460325 Selective miRNA expression profile in chronic myeloid leukemia K562 cell-derived exosomes. -circulation_biomarker_diagnosis_ns hsa-mir-4279 "Leukemia, Myeloid, Chronic" 24460325 Selective miRNA expression profile in chronic myeloid leukemia K562 cell-derived exosomes. -circulation_biomarker_diagnosis_ns hsa-mir-4290 "Leukemia, Myeloid, Chronic" 24460325 Selective miRNA expression profile in chronic myeloid leukemia K562 cell-derived exosomes. -circulation_biomarker_diagnosis_ns hsa-mir-483 "Leukemia, Myeloid, Chronic" 24460325 Selective miRNA expression profile in chronic myeloid leukemia K562 cell-derived exosomes. -circulation_biomarker_diagnosis_ns hsa-mir-498 "Leukemia, Myeloid, Chronic" 24460325 Selective miRNA expression profile in chronic myeloid leukemia K562 cell-derived exosomes. -circulation_biomarker_diagnosis_ns hsa-mir-518b "Leukemia, Myeloid, Chronic" 24460325 Selective miRNA expression profile in chronic myeloid leukemia K562 cell-derived exosomes. -circulation_biomarker_diagnosis_ns hsa-mir-525 "Leukemia, Myeloid, Chronic" 24460325 Selective miRNA expression profile in chronic myeloid leukemia K562 cell-derived exosomes. -circulation_biomarker_diagnosis_ns hsa-mir-612 "Leukemia, Myeloid, Chronic" 24460325 Selective miRNA expression profile in chronic myeloid leukemia K562 cell-derived exosomes. -circulation_biomarker_diagnosis_ns hsa-mir-665 "Leukemia, Myeloid, Chronic" 24460325 Selective miRNA expression profile in chronic myeloid leukemia K562 cell-derived exosomes. -circulation_biomarker_diagnosis_ns hsa-mir-711 "Leukemia, Myeloid, Chronic" 24460325 Selective miRNA expression profile in chronic myeloid leukemia K562 cell-derived exosomes. -circulation_biomarker_diagnosis_ns hsa-mir-943 "Leukemia, Myeloid, Chronic" 24460325 Selective miRNA expression profile in chronic myeloid leukemia K562 cell-derived exosomes. -circulation_biomarker_diagnosis_ns hsa-mir-1 "Muscular Dystrophy, Duchenne" 24460924 Serum miR-206 and other muscle-specific microRNAs as non-invasive biomarkers for Duchenne muscular dystrophy. -circulation_biomarker_diagnosis_ns hsa-mir-133 "Muscular Dystrophy, Duchenne" 24460924 Serum miR-206 and other muscle-specific microRNAs as non-invasive biomarkers for Duchenne muscular dystrophy. -circulation_biomarker_diagnosis_ns hsa-mir-206 "Muscular Dystrophy, Duchenne" 24460924 Serum miR-206 and other muscle-specific microRNAs as non-invasive biomarkers for Duchenne muscular dystrophy. -circulation_biomarker_diagnosis_ns hsa-mir-628 Prostate Neoplasms 24477576 "Our results demonstrate that the three miRNAs, particularly miR-628-5p, may be further developed as a biomarker, which can serve as novel noninvasive biomarker for PCa diagnosis and prognosis." -circulation_biomarker_diagnosis_ns hsa-mir-126 "Leukemia, Myeloid, Acute" 24477595 Attenuation of microRNA-126 expression that drives CD34+38- stem/progenitor cells in acute myeloid leukemia leads to tumor eradication. -circulation_biomarker_diagnosis_ns hsa-mir-122 Gastric Neoplasms 24481716 Plasma miR-122 and miR-192 as potential novel biomarkers for the early detection of distant metastasis of gastric cancer. -circulation_biomarker_diagnosis_ns hsa-mir-192 Gastric Neoplasms 24481716 Plasma miR-122 and miR-192 as potential novel biomarkers for the early detection of distant metastasis of gastric cancer. -circulation_biomarker_diagnosis_ns hsa-mir-182 Breast Neoplasms 24498016 "This study provides insight into the underlying molecular portrait of Luminal A-like breast cancer subtype. From an initial 76 miRNAs, 4 were validated with altered expression in the blood of women with Luminal A-like breast cancer. The expression profiles of these 3 miRNAs, in combination with mammography, has potential to facilitate accurate subtype-specific breast tumor detection." -circulation_biomarker_diagnosis_ns hsa-mir-19b Breast Neoplasms 24498016 "This study provides insight into the underlying molecular portrait of Luminal A-like breast cancer subtype. From an initial 76 miRNAs, 4 were validated with altered expression in the blood of women with Luminal A-like breast cancer. The expression profiles of these 3 miRNAs, in combination with mammography, has potential to facilitate accurate subtype-specific breast tumor detection." -circulation_biomarker_diagnosis_ns hsa-mir-223 Breast Neoplasms 24498016 "This study provides insight into the underlying molecular portrait of Luminal A-like breast cancer subtype. From an initial 76 miRNAs, 4 were validated with altered expression in the blood of women with Luminal A-like breast cancer. The expression profiles of these 3 miRNAs, in combination with mammography, has potential to facilitate accurate subtype-specific breast tumor detection." -circulation_biomarker_diagnosis_ns hsa-mir-29a Breast Neoplasms 24498016 "This study provides insight into the underlying molecular portrait of Luminal A-like breast cancer subtype. From an initial 76 miRNAs, 4 were validated with altered expression in the blood of women with Luminal A-like breast cancer. The expression profiles of these 3 miRNAs, in combination with mammography, has potential to facilitate accurate subtype-specific breast tumor detection." -circulation_biomarker_diagnosis_ns hsa-mir-301a Breast Neoplasms 24498016 "This study provides insight into the underlying molecular portrait of Luminal A-like breast cancer subtype. From an initial 76 miRNAs, 4 were validated with altered expression in the blood of women with Luminal A-like breast cancer. The expression profiles of these 3 miRNAs, in combination with mammography, has potential to facilitate accurate subtype-specific breast tumor detection." -circulation_biomarker_diagnosis_ns hsa-mir-423 Breast Neoplasms 24498016 "This study provides insight into the underlying molecular portrait of Luminal A-like breast cancer subtype. From an initial 76 miRNAs, 4 were validated with altered expression in the blood of women with Luminal A-like breast cancer. The expression profiles of these 3 miRNAs, in combination with mammography, has potential to facilitate accurate subtype-specific breast tumor detection." -circulation_biomarker_diagnosis_ns hsa-mir-486 Breast Neoplasms 24498016 "This study provides insight into the underlying molecular portrait of Luminal A-like breast cancer subtype. From an initial 76 miRNAs, 4 were validated with altered expression in the blood of women with Luminal A-like breast cancer. The expression profiles of these 3 miRNAs, in combination with mammography, has potential to facilitate accurate subtype-specific breast tumor detection." -circulation_biomarker_diagnosis_ns hsa-mir-652 Breast Neoplasms 24498016 "This study provides insight into the underlying molecular portrait of Luminal A-like breast cancer subtype. From an initial 76 miRNAs, 4 were validated with altered expression in the blood of women with Luminal A-like breast cancer. The expression profiles of these 3 miRNAs, in combination with mammography, has potential to facilitate accurate subtype-specific breast tumor detection." -circulation_biomarker_diagnosis_ns hsa-mir-93 Breast Neoplasms 24498016 "This study provides insight into the underlying molecular portrait of Luminal A-like breast cancer subtype. From an initial 76 miRNAs, 4 were validated with altered expression in the blood of women with Luminal A-like breast cancer. The expression profiles of these 3 miRNAs, in combination with mammography, has potential to facilitate accurate subtype-specific breast tumor detection." -circulation_biomarker_diagnosis_ns hsa-mir-21 Myelodysplastic Syndromes 24503739 Serum microRNA-21 as a potential biomarker for response to hypomethylating agents in myelodysplastic syndromes. -circulation_biomarker_diagnosis_ns hsa-mir-29c Early-Stage Non-Small-Cell Lung Carcinoma 24523873 "The results of the current study suggest that detection of serum miR-29c and miR-429 expression should be further evaluated as a novel,non-invasive biomarker for early stage NSCLC." -circulation_biomarker_diagnosis_ns hsa-mir-429 Early-Stage Non-Small-Cell Lung Carcinoma 24523873 "The results of the current study suggest that detection of serum miR-29c and miR-429 expression should be further evaluated as a novel,non-invasive biomarker for early stage NSCLC." -circulation_biomarker_diagnosis_ns hsa-mir-93 Early-Stage Non-Small-Cell Lung Carcinoma 24523873 "The results of the current study suggest that detection of serum miR-29c and miR-429 expression should be further evaluated as a novel,non-invasive biomarker for early stage NSCLC." -circulation_biomarker_diagnosis_ns hsa-mir-499 Myocardial Infarction 24533109 "MiRNAs, especially miR-499 and miR-133a, may be suitable for use as diagnostic biomarkers of myocardial infarction." -circulation_biomarker_diagnosis_ns hsa-mir-499 "Carcinoma, Lung, Non-Small-Cell" 24549225 Serum miR-499 as a novel diagnostic and prognostic biomarker in non-small cell lung cancer. -circulation_biomarker_diagnosis_ns hsa-mir-206 Early-Stage Lung Carcinoma 24553369 4-(Methylnitrosamino)-1-(3-pyridyl) -1-butanone induces circulating microRNA deregulation in early lung carcinogenesis. -circulation_biomarker_diagnosis_ns hsa-mir-210 Early-Stage Lung Carcinoma 24553369 4-(Methylnitrosamino)-1-(3-pyridyl) -1-butanone induces circulating microRNA deregulation in early lung carcinogenesis. -circulation_biomarker_diagnosis_ns hsa-mir-223 Cardiovascular Diseases [unspecific] 24573468 Smoking alters circulating plasma microvesicle pattern and microRNA signatures. -circulation_biomarker_diagnosis_ns hsa-mir-29b Cardiovascular Diseases [unspecific] 24573468 Smoking alters circulating plasma microvesicle pattern and microRNA signatures. -circulation_biomarker_diagnosis_ns hsa-mir-34a Colorectal Carcinoma 24573638 Detection of miR-34a and miR-34b/c in stool sample as potential screening biomarkers for noninvasive diagnosis of colorectal cancer. -circulation_biomarker_diagnosis_ns hsa-mir-34b Colorectal Carcinoma 24573638 Detection of miR-34a and miR-34b/c in stool sample as potential screening biomarkers for noninvasive diagnosis of colorectal cancer. -circulation_biomarker_diagnosis_ns hsa-mir-34c Colorectal Carcinoma 24573638 Detection of miR-34a and miR-34b/c in stool sample as potential screening biomarkers for noninvasive diagnosis of colorectal cancer. -circulation_biomarker_diagnosis_ns hsa-let-7d Alzheimer Disease 24577456 Genome-wide serum microRNA expression profiling identifies serum biomarkers for Alzheimer's disease. -circulation_biomarker_diagnosis_ns hsa-mir-191 Alzheimer Disease 24577456 Genome-wide serum microRNA expression profiling identifies serum biomarkers for Alzheimer's disease. -circulation_biomarker_diagnosis_ns hsa-mir-342 Alzheimer Disease 24577456 Genome-wide serum microRNA expression profiling identifies serum biomarkers for Alzheimer's disease. -circulation_biomarker_diagnosis_ns hsa-mir-483 Alzheimer Disease 24577456 Genome-wide serum microRNA expression profiling identifies serum biomarkers for Alzheimer's disease. -circulation_biomarker_diagnosis_ns hsa-mir-885 Alzheimer Disease 24577456 Genome-wide serum microRNA expression profiling identifies serum biomarkers for Alzheimer's disease. -circulation_biomarker_diagnosis_ns hsa-mir-98 Alzheimer Disease 24577456 Genome-wide serum microRNA expression profiling identifies serum biomarkers for Alzheimer's disease. -circulation_biomarker_diagnosis_ns hsa-let-7a Breast Neoplasms 24584717 "In summary, the data suggested that miRNAs in milk from milk stasis patients may contribute to breast carcinogenesis and that they are more sensitive biomarkers for breast cancer than miRNAs in the blood." -circulation_biomarker_diagnosis_ns hsa-mir-10 Breast Neoplasms 24584717 "In summary, the data suggested that miRNAs in milk from milk stasis patients may contribute to breast carcinogenesis and that they are more sensitive biomarkers for breast cancer than miRNAs in the blood." -circulation_biomarker_diagnosis_ns hsa-mir-107 Breast Neoplasms 24584717 "In summary, the data suggested that miRNAs in milk from milk stasis patients may contribute to breast carcinogenesis and that they are more sensitive biomarkers for breast cancer than miRNAs in the blood." -circulation_biomarker_diagnosis_ns hsa-mir-140 Breast Neoplasms 24584717 "In summary, the data suggested that miRNAs in milk from milk stasis patients may contribute to breast carcinogenesis and that they are more sensitive biomarkers for breast cancer than miRNAs in the blood." -circulation_biomarker_diagnosis_ns hsa-mir-146 Breast Neoplasms 24584717 "In summary, the data suggested that miRNAs in milk from milk stasis patients may contribute to breast carcinogenesis and that they are more sensitive biomarkers for breast cancer than miRNAs in the blood." -circulation_biomarker_diagnosis_ns hsa-mir-21 Breast Neoplasms 24584717 "In summary, the data suggested that miRNAs in milk from milk stasis patients may contribute to breast carcinogenesis and that they are more sensitive biomarkers for breast cancer than miRNAs in the blood." -circulation_biomarker_diagnosis_ns hsa-mir-223 Breast Neoplasms 24584717 "In summary, the data suggested that miRNAs in milk from milk stasis patients may contribute to breast carcinogenesis and that they are more sensitive biomarkers for breast cancer than miRNAs in the blood." -circulation_biomarker_diagnosis_ns hsa-mir-29a Breast Neoplasms 24584717 "In summary, the data suggested that miRNAs in milk from milk stasis patients may contribute to breast carcinogenesis and that they are more sensitive biomarkers for breast cancer than miRNAs in the blood." -circulation_biomarker_diagnosis_ns hsa-mir-451 Breast Neoplasms 24584717 "In summary, the data suggested that miRNAs in milk from milk stasis patients may contribute to breast carcinogenesis and that they are more sensitive biomarkers for breast cancer than miRNAs in the blood." -circulation_biomarker_diagnosis_ns hsa-mir-486 Breast Neoplasms 24584717 "In summary, the data suggested that miRNAs in milk from milk stasis patients may contribute to breast carcinogenesis and that they are more sensitive biomarkers for breast cancer than miRNAs in the blood." -circulation_biomarker_diagnosis_ns hsa-mir-92 Breast Neoplasms 24584717 "In summary, the data suggested that miRNAs in milk from milk stasis patients may contribute to breast carcinogenesis and that they are more sensitive biomarkers for breast cancer than miRNAs in the blood." -circulation_biomarker_diagnosis_ns hsa-mir-21 Colorectal Carcinoma 24586105 Re: Serum miR-21 as a diagnostic and prognostic biomarker in colorectal cancer. -circulation_biomarker_diagnosis_ns hsa-mir-206 Amyotrophic Lateral Sclerosis 24586506 MicroRNA-206: a potential circulating biomarker candidate for amyotrophic lateral sclerosis. -circulation_biomarker_diagnosis_ns hsa-mir-122 Non-Neoplastic Diseases 24586876 "Only a subset of reported blood-based microRNA biomarkers have specificity for a particular disease. The remainder of the reported non-neoplastic biomarkers are either biologically implausible, non-specific, or uninterpretable due to limitations of our current understanding of microRNA expression." -circulation_biomarker_diagnosis_ns hsa-mir-126 Non-Neoplastic Diseases 24586876 "Only a subset of reported blood-based microRNA biomarkers have specificity for a particular disease. The remainder of the reported non-neoplastic biomarkers are either biologically implausible, non-specific, or uninterpretable due to limitations of our current understanding of microRNA expression." -circulation_biomarker_diagnosis_ns hsa-mir-146a Non-Neoplastic Diseases 24586876 "Only a subset of reported blood-based microRNA biomarkers have specificity for a particular disease. The remainder of the reported non-neoplastic biomarkers are either biologically implausible, non-specific, or uninterpretable due to limitations of our current understanding of microRNA expression." -circulation_biomarker_diagnosis_ns hsa-mir-155 Non-Neoplastic Diseases 24586876 "Only a subset of reported blood-based microRNA biomarkers have specificity for a particular disease. The remainder of the reported non-neoplastic biomarkers are either biologically implausible, non-specific, or uninterpretable due to limitations of our current understanding of microRNA expression." -circulation_biomarker_diagnosis_ns hsa-mir-16 Non-Neoplastic Diseases 24586876 "Only a subset of reported blood-based microRNA biomarkers have specificity for a particular disease. The remainder of the reported non-neoplastic biomarkers are either biologically implausible, non-specific, or uninterpretable due to limitations of our current understanding of microRNA expression." -circulation_biomarker_diagnosis_ns hsa-mir-21 Non-Neoplastic Diseases 24586876 "Only a subset of reported blood-based microRNA biomarkers have specificity for a particular disease. The remainder of the reported non-neoplastic biomarkers are either biologically implausible, non-specific, or uninterpretable due to limitations of our current understanding of microRNA expression." -circulation_biomarker_diagnosis_ns hsa-mir-223 Non-Neoplastic Diseases 24586876 "Only a subset of reported blood-based microRNA biomarkers have specificity for a particular disease. The remainder of the reported non-neoplastic biomarkers are either biologically implausible, non-specific, or uninterpretable due to limitations of our current understanding of microRNA expression." -circulation_biomarker_diagnosis_ns hsa-mir-16 Early-Stage Gastric Carcinoma 24595006 A five-microRNA panel in plasma was identified as potential biomarker for early detection of gastric cancer. -circulation_biomarker_diagnosis_ns hsa-mir-25 Early-Stage Gastric Carcinoma 24595006 A five-microRNA panel in plasma was identified as potential biomarker for early detection of gastric cancer. -circulation_biomarker_diagnosis_ns hsa-mir-451 Early-Stage Gastric Carcinoma 24595006 A five-microRNA panel in plasma was identified as potential biomarker for early detection of gastric cancer. -circulation_biomarker_diagnosis_ns hsa-mir-486 Early-Stage Gastric Carcinoma 24595006 A five-microRNA panel in plasma was identified as potential biomarker for early detection of gastric cancer. -circulation_biomarker_diagnosis_ns hsa-mir-92a Early-Stage Gastric Carcinoma 24595006 A five-microRNA panel in plasma was identified as potential biomarker for early detection of gastric cancer. -circulation_biomarker_diagnosis_ns hsa-mir-125b Hepatitis B Virus Infection 24595450 Profiles of serum microRNAs; miR-125b-5p and miR223-3p serve as novel biomarkers for HBV-positive hepatocellular carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-223 Hepatitis B Virus Infection 24595450 Profiles of serum microRNAs; miR-125b-5p and miR223-3p serve as novel biomarkers for HBV-positive hepatocellular carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-16 "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 24598659 Expression of miR-16 in patients with T lymphoblastic lymphoma/acute lymphoblastic leukemia. -circulation_biomarker_diagnosis_ns hsa-mir-425 Gastric Neoplasms 24603541 "Taken together, our results revealed the oncogenic roles of miR-191 and miR-425 in gastric carcinogenesis, and indicated the potential use of serum miR-191 as a novel and stable biomarker for GC diagnosis." -circulation_biomarker_diagnosis_ns hsa-mir-18a Gastric Neoplasms 24626859 Circulating miR-18a could be a useful biomarker for screening GC and monitoring tumor dynamics. -circulation_biomarker_diagnosis_ns hsa-mir-122 Myasthenia Gravis 24637658 Analysis of serum miRNA profiles of myasthenia gravis patients. -circulation_biomarker_diagnosis_ns hsa-mir-140 Myasthenia Gravis 24637658 Analysis of serum miRNA profiles of myasthenia gravis patients. -circulation_biomarker_diagnosis_ns hsa-mir-15b Myasthenia Gravis 24637658 Analysis of serum miRNA profiles of myasthenia gravis patients. -circulation_biomarker_diagnosis_ns hsa-mir-185 Myasthenia Gravis 24637658 Analysis of serum miRNA profiles of myasthenia gravis patients. -circulation_biomarker_diagnosis_ns hsa-mir-192 Myasthenia Gravis 24637658 Analysis of serum miRNA profiles of myasthenia gravis patients. -circulation_biomarker_diagnosis_ns hsa-mir-20b Myasthenia Gravis 24637658 Analysis of serum miRNA profiles of myasthenia gravis patients. -circulation_biomarker_diagnosis_ns hsa-mir-885 Myasthenia Gravis 24637658 Analysis of serum miRNA profiles of myasthenia gravis patients. -circulation_biomarker_diagnosis_ns hsa-mir-106b Ovarian Neoplasms 24641401 "This study shows that Solexa sequencing provides a promising method for cancer-related miRNA profiling, and selectively expressed miRNAs could be used as potential serum-based biomarkers for ovarian cancer diagnosis." -circulation_biomarker_diagnosis_ns hsa-mir-22 Ovarian Neoplasms 24641401 "This study shows that Solexa sequencing provides a promising method for cancer-related miRNA profiling, and selectively expressed miRNAs could be used as potential serum-based biomarkers for ovarian cancer diagnosis." -circulation_biomarker_diagnosis_ns hsa-mir-451 Ovarian Neoplasms 24641401 "This study shows that Solexa sequencing provides a promising method for cancer-related miRNA profiling, and selectively expressed miRNAs could be used as potential serum-based biomarkers for ovarian cancer diagnosis." -circulation_biomarker_diagnosis_ns hsa-mir-93 Ovarian Neoplasms 24641401 "This study shows that Solexa sequencing provides a promising method for cancer-related miRNA profiling, and selectively expressed miRNAs could be used as potential serum-based biomarkers for ovarian cancer diagnosis." -circulation_biomarker_diagnosis_ns hsa-mir-484 Early-Stage Breast Carcinoma 24641801 "In this study, we found that miR-484 is significantly differentially expressed in serum of early breast cancer patients compared to healthy volunteers. We did not however find any correlation between miR-484 levels with histopathological parameters of the breast cancers. With further studies, miR-484 may prove useful as an adjunct to mammography for detection of early breast cancer." -circulation_biomarker_diagnosis_ns hsa-mir-122 Chronic Hepatitis B 24643113 "Comparison of circulating, hepatocyte specific messenger RNA and microRNA as biomarkers for chronic hepatitis B and C." -circulation_biomarker_diagnosis_ns hsa-mir-122 Chronic Hepatitis C 24643113 "Comparison of circulating, hepatocyte specific messenger RNA and microRNA as biomarkers for chronic hepatitis B and C." -circulation_biomarker_diagnosis_ns hsa-mir-15b Colorectal Carcinoma 24646542 miR-15b and miR-17 Are Tumor-derived Plasma MicroRNAs Dysregulated in Colorectal Neoplasia. -circulation_biomarker_diagnosis_ns hsa-mir-17 Colorectal Carcinoma 24646542 miR-15b and miR-17 Are Tumor-derived Plasma MicroRNAs Dysregulated in Colorectal Neoplasia. -circulation_biomarker_diagnosis_ns hsa-mir-33 Psoriasis 24656994 In psoriasis patients plasma levels of lipid and glucose metabolism-related miRNA-33 are increased and correlated with insulin. The study of circulating miRNA-33 in psoriasis may provide new insights about the associated systemic inflammatory abnormalities. -circulation_biomarker_diagnosis_ns hsa-mir-223 "Lymphoma, Non-Hodgkin" 24675587 "Altered serum levels of miR-21, miR-122, and miR-223 are seen in HIV-infected individuals." -circulation_biomarker_diagnosis_ns hsa-mir-135b Colorectal Carcinoma 24691020 Stool-based miR-135b can be used as a noninvasive biomarker for the detection of CRC and advanced adenoma. -circulation_biomarker_diagnosis_ns hsa-mir-107 Early-Stage Breast Carcinoma 24694649 "We present herein a 9 miRNA signature capable of discriminating between ER-positive breast cancer and healthy controls. Using a specific algorithm based on the 9 miRNA signature, the risk for future individuals can be predicted. Since microRNAs are highly stable in blood components, this signature might be useful in the development of a blood-based multi-marker test to improve early detection of breast cancer. Such a test could potentially be used as a screening tool to identify individuals who would benefit from further diagnostic assessment." -circulation_biomarker_diagnosis_ns hsa-mir-133a Early-Stage Breast Carcinoma 24694649 "We present herein a 9 miRNA signature capable of discriminating between ER-positive breast cancer and healthy controls. Using a specific algorithm based on the 9 miRNA signature, the risk for future individuals can be predicted. Since microRNAs are highly stable in blood components, this signature might be useful in the development of a blood-based multi-marker test to improve early detection of breast cancer. Such a test could potentially be used as a screening tool to identify individuals who would benefit from further diagnostic assessment." -circulation_biomarker_diagnosis_ns hsa-mir-139 Early-Stage Breast Carcinoma 24694649 "We present herein a 9 miRNA signature capable of discriminating between ER-positive breast cancer and healthy controls. Using a specific algorithm based on the 9 miRNA signature, the risk for future individuals can be predicted. Since microRNAs are highly stable in blood components, this signature might be useful in the development of a blood-based multi-marker test to improve early detection of breast cancer. Such a test could potentially be used as a screening tool to identify individuals who would benefit from further diagnostic assessment." -circulation_biomarker_diagnosis_ns hsa-mir-143 Early-Stage Breast Carcinoma 24694649 "We present herein a 9 miRNA signature capable of discriminating between ER-positive breast cancer and healthy controls. Using a specific algorithm based on the 9 miRNA signature, the risk for future individuals can be predicted. Since microRNAs are highly stable in blood components, this signature might be useful in the development of a blood-based multi-marker test to improve early detection of breast cancer. Such a test could potentially be used as a screening tool to identify individuals who would benefit from further diagnostic assessment." -circulation_biomarker_diagnosis_ns hsa-mir-145 Early-Stage Breast Carcinoma 24694649 "We present herein a 9 miRNA signature capable of discriminating between ER-positive breast cancer and healthy controls. Using a specific algorithm based on the 9 miRNA signature, the risk for future individuals can be predicted. Since microRNAs are highly stable in blood components, this signature might be useful in the development of a blood-based multi-marker test to improve early detection of breast cancer. Such a test could potentially be used as a screening tool to identify individuals who would benefit from further diagnostic assessment." -circulation_biomarker_diagnosis_ns hsa-mir-15a Early-Stage Breast Carcinoma 24694649 "We present herein a 9 miRNA signature capable of discriminating between ER-positive breast cancer and healthy controls. Using a specific algorithm based on the 9 miRNA signature, the risk for future individuals can be predicted. Since microRNAs are highly stable in blood components, this signature might be useful in the development of a blood-based multi-marker test to improve early detection of breast cancer. Such a test could potentially be used as a screening tool to identify individuals who would benefit from further diagnostic assessment." -circulation_biomarker_diagnosis_ns hsa-mir-18a Early-Stage Breast Carcinoma 24694649 "We present herein a 9 miRNA signature capable of discriminating between ER-positive breast cancer and healthy controls. Using a specific algorithm based on the 9 miRNA signature, the risk for future individuals can be predicted. Since microRNAs are highly stable in blood components, this signature might be useful in the development of a blood-based multi-marker test to improve early detection of breast cancer. Such a test could potentially be used as a screening tool to identify individuals who would benefit from further diagnostic assessment." -circulation_biomarker_diagnosis_ns hsa-mir-365 Early-Stage Breast Carcinoma 24694649 "We present herein a 9 miRNA signature capable of discriminating between ER-positive breast cancer and healthy controls. Using a specific algorithm based on the 9 miRNA signature, the risk for future individuals can be predicted. Since microRNAs are highly stable in blood components, this signature might be useful in the development of a blood-based multi-marker test to improve early detection of breast cancer. Such a test could potentially be used as a screening tool to identify individuals who would benefit from further diagnostic assessment." -circulation_biomarker_diagnosis_ns hsa-mir-425 Early-Stage Breast Carcinoma 24694649 "We present herein a 9 miRNA signature capable of discriminating between ER-positive breast cancer and healthy controls. Using a specific algorithm based on the 9 miRNA signature, the risk for future individuals can be predicted. Since microRNAs are highly stable in blood components, this signature might be useful in the development of a blood-based multi-marker test to improve early detection of breast cancer. Such a test could potentially be used as a screening tool to identify individuals who would benefit from further diagnostic assessment." -circulation_biomarker_diagnosis_ns hsa-let-7f "Carcinoma, Hepatocellular" 24697119 "Serum miR-16, let-7f, and miR-21 are related with the biological behavior of HCC, which means that they could be considered as the potential indicators to estimate the tumor size or the recurrence of HCC." -circulation_biomarker_diagnosis_ns hsa-mir-16 "Carcinoma, Hepatocellular" 24697119 "Serum miR-16, let-7f, and miR-21 are related with the biological behavior of HCC, which means that they could be considered as the potential indicators to estimate the tumor size or the recurrence of HCC." -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Hepatocellular" 24697119 "Serum miR-16, let-7f, and miR-21 are related with the biological behavior of HCC, which means that they could be considered as the potential indicators to estimate the tumor size or the recurrence of HCC." -circulation_biomarker_diagnosis_ns hsa-mir-17 Influenza 24699363 Comprehensive characterization of serum microRNA profile in response to the emerging avian influenza A (H7N9) virus infection in humans. -circulation_biomarker_diagnosis_ns hsa-mir-20a Influenza 24699363 Comprehensive characterization of serum microRNA profile in response to the emerging avian influenza A (H7N9) virus infection in humans. -circulation_biomarker_diagnosis_ns hsa-mir-376c Influenza 24699363 Comprehensive characterization of serum microRNA profile in response to the emerging avian influenza A (H7N9) virus infection in humans. -circulation_biomarker_diagnosis_ns hsa-let-7g Colorectal Carcinoma 24709885 Identification of a circulating microRNA signature for colorectal cancer detection. -circulation_biomarker_diagnosis_ns hsa-mir-181b Colorectal Carcinoma 24709885 Identification of a circulating microRNA signature for colorectal cancer detection. -circulation_biomarker_diagnosis_ns hsa-mir-203 Colorectal Carcinoma 24709885 Identification of a circulating microRNA signature for colorectal cancer detection. -circulation_biomarker_diagnosis_ns hsa-mir-21 Colorectal Carcinoma 24709885 Identification of a circulating microRNA signature for colorectal cancer detection. -circulation_biomarker_diagnosis_ns hsa-mir-31 Colorectal Carcinoma 24709885 Identification of a circulating microRNA signature for colorectal cancer detection. -circulation_biomarker_diagnosis_ns hsa-mir-92a Colorectal Carcinoma 24709885 Identification of a circulating microRNA signature for colorectal cancer detection. -circulation_biomarker_diagnosis_ns hsa-mir-186 Myocardial Infarction 24727883 "In a validation phase, a miRNA panel including miR-132, miR-150, and miR-186 showed the highest discriminatory power" -circulation_biomarker_diagnosis_ns hsa-mir-105 Breast Neoplasms 24735924 "miR-105 can be detected in the circulation at the premetastatic stage, and its levels in the blood and tumor are associated with ZO-1 expression and metastatic progression in early-stage breast cancer." -circulation_biomarker_diagnosis_ns hsa-mir-150 Irritable Bowel Syndrome 24768587 "This preliminary study reports the association of two miRNAs,detected in whole blood, with IBS. These miRNAs link to pain and inflammatory pathways both of which are thought to be dysregulated in IBS. Larger sample sizes are needed to confirm their importance and potential as biomarkers." -circulation_biomarker_diagnosis_ns hsa-mir-342 Irritable Bowel Syndrome 24768587 "This preliminary study reports the association of two miRNAs,detected in whole blood, with IBS. These miRNAs link to pain and inflammatory pathways both of which are thought to be dysregulated in IBS. Larger sample sizes are needed to confirm their importance and potential as biomarkers." -circulation_biomarker_diagnosis_ns hsa-mir-1207 Metabolic Syndrome 24784704 Blood microRNA profile associates with the levels of serum lipids and metabolites associated with glucose metabolism and insulin resistance and pinpoints pathways underlying metabolic syndrome: the cardiovascular risk in Young Finns Study. -circulation_biomarker_diagnosis_ns hsa-mir-1237 Metabolic Syndrome 24784704 Blood microRNA profile associates with the levels of serum lipids and metabolites associated with glucose metabolism and insulin resistance and pinpoints pathways underlying metabolic syndrome: the cardiovascular risk in Young Finns Study. -circulation_biomarker_diagnosis_ns hsa-mir-1288 Metabolic Syndrome 24784704 Blood microRNA profile associates with the levels of serum lipids and metabolites associated with glucose metabolism and insulin resistance and pinpoints pathways underlying metabolic syndrome: the cardiovascular risk in Young Finns Study. -circulation_biomarker_diagnosis_ns hsa-mir-129-1 Metabolic Syndrome 24784704 Blood microRNA profile associates with the levels of serum lipids and metabolites associated with glucose metabolism and insulin resistance and pinpoints pathways underlying metabolic syndrome: the cardiovascular risk in Young Finns Study. -circulation_biomarker_diagnosis_ns hsa-mir-129-2 Metabolic Syndrome 24784704 Blood microRNA profile associates with the levels of serum lipids and metabolites associated with glucose metabolism and insulin resistance and pinpoints pathways underlying metabolic syndrome: the cardiovascular risk in Young Finns Study. -circulation_biomarker_diagnosis_ns hsa-mir-144 Metabolic Syndrome 24784704 Blood microRNA profile associates with the levels of serum lipids and metabolites associated with glucose metabolism and insulin resistance and pinpoints pathways underlying metabolic syndrome: the cardiovascular risk in Young Finns Study. -circulation_biomarker_diagnosis_ns hsa-mir-331 Metabolic Syndrome 24784704 Blood microRNA profile associates with the levels of serum lipids and metabolites associated with glucose metabolism and insulin resistance and pinpoints pathways underlying metabolic syndrome: the cardiovascular risk in Young Finns Study. -circulation_biomarker_diagnosis_ns hsa-mir-484 Metabolic Syndrome 24784704 Blood microRNA profile associates with the levels of serum lipids and metabolites associated with glucose metabolism and insulin resistance and pinpoints pathways underlying metabolic syndrome: the cardiovascular risk in Young Finns Study. -circulation_biomarker_diagnosis_ns hsa-mir-625 Metabolic Syndrome 24784704 Blood microRNA profile associates with the levels of serum lipids and metabolites associated with glucose metabolism and insulin resistance and pinpoints pathways underlying metabolic syndrome: the cardiovascular risk in Young Finns Study. -circulation_biomarker_diagnosis_ns hsa-mir-18a Neoplasms [unspecific] 24815829 Circulating miR-18a: a sensitive cancer screening biomarker in human cancer. -circulation_biomarker_diagnosis_ns hsa-mir-21 Acute Cerebral Infarction 24841240 Identification of miRNA-21 and miRNA-24 in plasma as potential early stage markers of acute cerebral infarction. -circulation_biomarker_diagnosis_ns hsa-mir-24 Acute Cerebral Infarction 24841240 Identification of miRNA-21 and miRNA-24 in plasma as potential early stage markers of acute cerebral infarction. -circulation_biomarker_diagnosis_ns hsa-mir-3620 Immune Thrombocytopenic Purpura 24851893 The plasma differential miRNA profiles are identified in ITP patients. And miRNA is involved in calcium signaling pathway and T cell receptor signaling pathway may be associated with ITP pathogenesis. -circulation_biomarker_diagnosis_ns hsa-mir-378i Immune Thrombocytopenic Purpura 24851893 The plasma differential miRNA profiles are identified in ITP patients. And miRNA is involved in calcium signaling pathway and T cell receptor signaling pathway may be associated with ITP pathogenesis. -circulation_biomarker_diagnosis_ns hsa-mir-4721 Immune Thrombocytopenic Purpura 24851893 The plasma differential miRNA profiles are identified in ITP patients. And miRNA is involved in calcium signaling pathway and T cell receptor signaling pathway may be associated with ITP pathogenesis. -circulation_biomarker_diagnosis_ns hsa-let-7g Glioma 24858071 miRNA profile of the peripheral blood may serve as a new biomarker for glioma diagnosis with high specificity and sensitivity. -circulation_biomarker_diagnosis_ns hsa-mir-320 Glioma 24858071 miRNA profile of the peripheral blood may serve as a new biomarker for glioma diagnosis with high specificity and sensitivity. -circulation_biomarker_diagnosis_ns hsa-mir-340 Glioma 24858071 miRNA profile of the peripheral blood may serve as a new biomarker for glioma diagnosis with high specificity and sensitivity. -circulation_biomarker_diagnosis_ns hsa-mir-576 Glioma 24858071 miRNA profile of the peripheral blood may serve as a new biomarker for glioma diagnosis with high specificity and sensitivity. -circulation_biomarker_diagnosis_ns hsa-mir-626 Glioma 24858071 miRNA profile of the peripheral blood may serve as a new biomarker for glioma diagnosis with high specificity and sensitivity. -circulation_biomarker_diagnosis_ns hsa-mir-7 Glioma 24858071 miRNA profile of the peripheral blood may serve as a new biomarker for glioma diagnosis with high specificity and sensitivity. -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Lung" 24865991 The current evidence suggests that serum miR-21 can be rapidly measured in lung carcinoma patients and has potential diagnostic value with moderate sensitivity and specificity. Further prospective studies to assess the early stage diagnostic value are needed in the future. -circulation_biomarker_diagnosis_ns hsa-mir-126 Cardiovascular Diseases [unspecific] 24874084 We have demonstrated that this panel of five serum miRNAs is expected to become potential non-invasive biomarkers for detection of MB. -circulation_biomarker_diagnosis_ns hsa-mir-151 Cardiovascular Diseases [unspecific] 24874084 We have demonstrated that this panel of five serum miRNAs is expected to become potential non-invasive biomarkers for detection of MB. -circulation_biomarker_diagnosis_ns hsa-mir-29b Cardiovascular Diseases [unspecific] 24874084 We have demonstrated that this panel of five serum miRNAs is expected to become potential non-invasive biomarkers for detection of MB. -circulation_biomarker_diagnosis_ns hsa-mir-503 Cardiovascular Diseases [unspecific] 24874084 We have demonstrated that this panel of five serum miRNAs is expected to become potential non-invasive biomarkers for detection of MB. -circulation_biomarker_diagnosis_ns hsa-mir-645 Cardiovascular Diseases [unspecific] 24874084 We have demonstrated that this panel of five serum miRNAs is expected to become potential non-invasive biomarkers for detection of MB. -circulation_biomarker_diagnosis_ns hsa-mir-483 "Carcinoma, Nasopharyngeal" 24874644 Plasma microRNA profiling in nasopharyngeal carcinoma patients reveals miR-548q and miR-483-5p as potential biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-548q "Carcinoma, Nasopharyngeal" 24874644 Plasma microRNA profiling in nasopharyngeal carcinoma patients reveals miR-548q and miR-483-5p as potential biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-19 Prostate Neoplasms 24893170 "miR-19, miR-345, miR-519c-5p serum levels predict adverse pathology in prostate cancer patients eligible for active surveillance." -circulation_biomarker_diagnosis_ns hsa-mir-345 Prostate Neoplasms 24893170 "miR-19, miR-345, miR-519c-5p serum levels predict adverse pathology in prostate cancer patients eligible for active surveillance." -circulation_biomarker_diagnosis_ns hsa-mir-519c Prostate Neoplasms 24893170 "miR-19, miR-345, miR-519c-5p serum levels predict adverse pathology in prostate cancer patients eligible for active surveillance." -circulation_biomarker_diagnosis_ns hsa-mir-143 Psoriasis 24909097 "We suggest that changes in the miR-223 and miR-143 expressions in PBMCs from patients with psoriasis may serve as novel biomarkers for disease activity in psoriasis; however, further investigations are warranted to clarify their specific roles." -circulation_biomarker_diagnosis_ns hsa-mir-223 Psoriasis 24909097 "We suggest that changes in the miR-223 and miR-143 expressions in PBMCs from patients with psoriasis may serve as novel biomarkers for disease activity in psoriasis; however, further investigations are warranted to clarify their specific roles." -circulation_biomarker_diagnosis_ns hsa-mir-138 Ovarian Neoplasms 24911418 our study suggests that detecting these ovarian cancer specific miRNAs in plasma might serve as novel non-invasive biomarkers for ovarian cancer. -circulation_biomarker_diagnosis_ns hsa-mir-126 Diabetes Mellitus 24927146 The role of circulating microRNA-126 (miR-126): a novel biomarker for screening prediabetes and newly diagnosed type 2 diabetes mellitus. -circulation_biomarker_diagnosis_ns hsa-mir-200c Gastric Neoplasms 24947260 "GDF15 and MMP7 serum levels have diagnostic value for GC. The combination marker formed by GDF15, MMP7 and miR-200c is indicative of adverse evolution in GC patients." -circulation_biomarker_diagnosis_ns hsa-mir-146a "Leukemia, Lymphoblastic, Acute" 24955371 these miRNAs not only may be used as biomarkers in diagnosis of ALL and monitoring the disease but also provide new insights into the potential roles of them in leukemogenesis. -circulation_biomarker_diagnosis_ns hsa-mir-155 "Leukemia, Lymphoblastic, Acute" 24955371 these miRNAs not only may be used as biomarkers in diagnosis of ALL and monitoring the disease but also provide new insights into the potential roles of them in leukemogenesis. -circulation_biomarker_diagnosis_ns hsa-mir-195 "Leukemia, Lymphoblastic, Acute" 24955371 these miRNAs not only may be used as biomarkers in diagnosis of ALL and monitoring the disease but also provide new insights into the potential roles of them in leukemogenesis. -circulation_biomarker_diagnosis_ns hsa-mir-152 Bladder Neoplasms 24961907 expression level of serum miR-152 could provide information on the recurrence risk of NMIBC. -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Hepatocellular" 24963487 Expression of serum exosomal microRNA-21 in human hepatocellular carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Esophageal" 24968850 "Both salivary and plasmatic miR-21 can be sensitive biomarkers for EC, and salivary miR-21 detection has the potential to replace plasma detection for EC diagnosis." -circulation_biomarker_diagnosis_ns hsa-mir-23a "Diabetes Mellitus, Type 2" 24981880 "Serum miR-23a, a potential biomarker for diagnosis of pre-diabetes and type 2 diabetes." -circulation_biomarker_diagnosis_ns hsa-mir-107 Breast Neoplasms 25004125 "A panel of 4 circulating miRNAs exhibited significantly altered levels following radical resection of primary ER+ breast cancers in post-menopausal women. These specific miRNAs may be involved in tumorigenesis and could potentially be used to monitor whether all cancer cells have been removed at surgery and/or, subsequently, whether the patients develop recurrence." -circulation_biomarker_diagnosis_ns hsa-mir-148a Breast Neoplasms 25004125 "A panel of 4 circulating miRNAs exhibited significantly altered levels following radical resection of primary ER+ breast cancers in post-menopausal women. These specific miRNAs may be involved in tumorigenesis and could potentially be used to monitor whether all cancer cells have been removed at surgery and/or, subsequently, whether the patients develop recurrence." -circulation_biomarker_diagnosis_ns hsa-mir-223 Breast Neoplasms 25004125 "A panel of 4 circulating miRNAs exhibited significantly altered levels following radical resection of primary ER+ breast cancers in post-menopausal women. These specific miRNAs may be involved in tumorigenesis and could potentially be used to monitor whether all cancer cells have been removed at surgery and/or, subsequently, whether the patients develop recurrence." -circulation_biomarker_diagnosis_ns hsa-mir-338 Breast Neoplasms 25004125 "A panel of 4 circulating miRNAs exhibited significantly altered levels following radical resection of primary ER+ breast cancers in post-menopausal women. These specific miRNAs may be involved in tumorigenesis and could potentially be used to monitor whether all cancer cells have been removed at surgery and/or, subsequently, whether the patients develop recurrence." -circulation_biomarker_diagnosis_ns hsa-mir-25 Pancreatic Neoplasms 25030590 "Plasma miR-21, miR-155, miR-25, miR-210 have diagnostic value for pancreatic cancer, and deserve further study." -circulation_biomarker_diagnosis_ns hsa-mir-1301 Preeclampsia 25064070 miR-1301 is dysregulated in early-onset preeclampsia and could possibly play a role in the regulation of leptin during pregnancy. -circulation_biomarker_diagnosis_ns hsa-mir-223 Preeclampsia 25064070 miR-1301 is dysregulated in early-onset preeclampsia and could possibly play a role in the regulation of leptin during pregnancy. -circulation_biomarker_diagnosis_ns hsa-mir-224 Preeclampsia 25064070 miR-1301 is dysregulated in early-onset preeclampsia and could possibly play a role in the regulation of leptin during pregnancy. -circulation_biomarker_diagnosis_ns hsa-mir-122 Hepatitis C Virus Infection 25065618 "miR-122, miR-126, miR-136 and miR-181a have been shown to be involved in HCV infection with different genotypes. Their expression has been associated with the gender, stage and grade of liver disease, mode of transmission, serum HCV load and the presence of steatosis." -circulation_biomarker_diagnosis_ns hsa-mir-126 Hepatitis C Virus Infection 25065618 "miR-122, miR-126, miR-136 and miR-181a have been shown to be involved in HCV infection with different genotypes. Their expression has been associated with the gender, stage and grade of liver disease, mode of transmission, serum HCV load and the presence of steatosis." -circulation_biomarker_diagnosis_ns hsa-mir-136 Hepatitis C Virus Infection 25065618 "miR-122, miR-126, miR-136 and miR-181a have been shown to be involved in HCV infection with different genotypes. Their expression has been associated with the gender, stage and grade of liver disease, mode of transmission, serum HCV load and the presence of steatosis." -circulation_biomarker_diagnosis_ns hsa-mir-181a Hepatitis C Virus Infection 25065618 "miR-122, miR-126, miR-136 and miR-181a have been shown to be involved in HCV infection with different genotypes. Their expression has been associated with the gender, stage and grade of liver disease, mode of transmission, serum HCV load and the presence of steatosis." -circulation_biomarker_diagnosis_ns hsa-mir-146a Sepsis 25086335 "So far, miR-223, miR-146a and miR-150 have been identified to have promising prognostic and diagnostic value to sepsis." -circulation_biomarker_diagnosis_ns hsa-mir-150 Sepsis 25086335 "So far, miR-223, miR-146a and miR-150 have been identified to have promising prognostic and diagnostic value to sepsis." -circulation_biomarker_diagnosis_ns hsa-mir-21 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 25099764 Combined detection of serum exosomal miR-21 and HOTAIR as diagnostic and prognostic biomarkers for laryngeal squamous cell carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-182 Colorectal Adenocarcinoma 25115394 Circulating miR-182 is a biomarker of colorectal adenocarcinoma progression. -circulation_biomarker_diagnosis_ns hsa-mir-25 "Squamous Cell Carcinoma, Esophageal" 25117812 Plasma miR-25 might be a clinically useful biomarker for cancer detection and the monitoring of tumour dynamics in ESCC patients. -circulation_biomarker_diagnosis_ns hsa-mir-193b Alzheimer Disease 25119742 MicroRNA-193b is a regulator of amyloid precursor protein in the blood and cerebrospinal fluid derived exosomal microRNA-193b is a biomarker of Alzheimer's disease. -circulation_biomarker_diagnosis_ns hsa-mir-375 Diabetes Mellitus 25120598 "Compared with the miR-375 levels in patients with normal glucose tolerance (NGT; n=53), the samples from patients with IGT (n=44) exhibited downregulation of miR-375, while those from patients with T2DM (n=54) exhibited upregulation of miR-375 in the plasma." -circulation_biomarker_diagnosis_ns hsa-mir-222 Gastric Neoplasms 25129310 Circulating miR-222 in plasma and its potential diagnostic and prognostic value in gastric cancer. -circulation_biomarker_diagnosis_ns hsa-mir-24 "Carcinoma, Hepatocellular" 25129312 Diagnostic and prognostic significance of serum miR-24-3p in HBV-related hepatocellular carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-124 Chronic Hepatitis B 25131617 Serum microRNA-124 is a novel biomarker for liver necroinflammation in patients with chronic hepatitis B virus infection. -circulation_biomarker_diagnosis_ns hsa-mir-29 Chronic Hepatitis B 25138057 Serum miR-29 levels are negatively correlated with liver fibrotic stages and necroinflammation grades in patients with chronic HBV infection. miR-29 appears to be a novel biomarkers for predicting disease progression in these patients. -circulation_biomarker_diagnosis_ns hsa-mir-1 Muscle Diseases [unspecific] 25146754 These miRNAs are potential biomarkers of muscle damage or adaptation to exercise. -circulation_biomarker_diagnosis_ns hsa-mir-1 "Muscular Dystrophy, Duchenne" 25150707 "Taken together, our data demonstrate that levels of miR-1, miR-133a, and miR-206 in serum of BMD and miR-1 in sera of LGMD and FSHD patients showed no significant differences compared with those of controls by Bonferroni correction. However, the results might need increase in sample sizes to evaluate these three miRNAs as variable biomarkers." -circulation_biomarker_diagnosis_ns hsa-mir-133a "Muscular Dystrophy, Duchenne" 25150707 "Taken together, our data demonstrate that levels of miR-1, miR-133a, and miR-206 in serum of BMD and miR-1 in sera of LGMD and FSHD patients showed no significant differences compared with those of controls by Bonferroni correction. However, the results might need increase in sample sizes to evaluate these three miRNAs as variable biomarkers." -circulation_biomarker_diagnosis_ns hsa-mir-206 "Muscular Dystrophy, Duchenne" 25150707 "Taken together, our data demonstrate that levels of miR-1, miR-133a, and miR-206 in serum of BMD and miR-1 in sera of LGMD and FSHD patients showed no significant differences compared with those of controls by Bonferroni correction. However, the results might need increase in sample sizes to evaluate these three miRNAs as variable biomarkers." -circulation_biomarker_diagnosis_ns hsa-mir-196a "Scleroderma, Localized" 25152444 Down-regulation of miR-196a and subsequent overexpression of type 1 collagen in dermal fibroblasts may play a key role in the pathogenesis of LSc. The serum levels of miR-196a may be useful as a diagnostic marker of LSc. -circulation_biomarker_diagnosis_ns hsa-mir-21 "Squamous Cell Carcinoma, Oral" 25174622 Circulating microRNA-21 (MIR-21) and phosphatase and tensin homolog (PTEN) are promising novel biomarkers for detection of oral squamous cell carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-148a Osteosarcoma 25185654 Circulating miR-148a is a significant diagnostic and prognostic biomarker for patients with osteosarcoma. -circulation_biomarker_diagnosis_ns hsa-mir-371a Germ Cell Tumor 25187505 MicroRNA miR-371a-3p in serum of patients with germ cell tumours: evaluations for establishing a serum biomarker. -circulation_biomarker_diagnosis_ns hsa-mir-192 Choriocarcinoma 25202432 "Normalization of miR-98 expression levels to those of U6 snRNA, miR-192 or a combination of these genes enabled the detection of a significant difference between BPE and LA-MPE samples." -circulation_biomarker_diagnosis_ns hsa-mir-708 "Leukemia, Lymphoblastic, Acute, Childhood" 25214155 MiR-708-5p is differentially expressed in childhood acute lymphoblastic leukemia but not strongly associated to clinical features. -circulation_biomarker_diagnosis_ns hsa-mir-483 Myeloma 25216866 Circulating microRNA 483-5p as a novel biomarker for diagnosis survival prediction in multiple myeloma. -circulation_biomarker_diagnosis_ns hsa-mir-106b Gastric Neoplasms 25218271 MicroRNA-106b~25 expressions in tumor tissues and plasma of patients with gastric cancers. -circulation_biomarker_diagnosis_ns hsa-mir-186 Focal Segmental Glomerulosclerosis 25218681 Plasma miR-186 may be a biomarker for FSGS with nephrotic proteinuria. -circulation_biomarker_diagnosis_ns hsa-mir-155 Systemic Lupus Erythematosus 25253569 Correcting the expression of miRNA-155 represses PP2Ac and enhances the release of IL-2 in PBMCs of juvenile SLE patients. -circulation_biomarker_diagnosis_ns hsa-mir-146a Sepsis 25265569 "miR-182, miR-143, miR-145, miR-146a, miR-150, and miR-155 were dysregulated in sepsis patients." -circulation_biomarker_diagnosis_ns hsa-mir-199a Colorectal Carcinoma 25269744 Circulating miR-199a-3p as a novel serum biomarker for colorectal cancer. -circulation_biomarker_diagnosis_ns hsa-mir-335 "Leukemia, Myeloid, Acute" 25301405 Our data offer the convincing evidence for the first time that serum miR-335 level may be markedly and consistently increased in pediatric AML patients. Serum miR-335 may serve as a promising marker for monitoring the progression and predicting the clinical outcome of patients with this disease. -circulation_biomarker_diagnosis_ns hsa-mir-182 Pancreatic Neoplasms 25326859 Circulating microRNA-182 in plasma and its potential diagnostic and prognostic value for pancreatic cancer. -circulation_biomarker_diagnosis_ns hsa-mir-126 Coronary Artery Disease 25327597 "Plasma miR-126 level is positively correlated to the CCC formation and is an independent predictor of CCC development in patients with severely narrowed coronary arteries, suggesting that plasma miR-126 might be a useful new, stable blood biomarker for predicting CCC formation in patients with severely narrowed coronary arteries." -circulation_biomarker_diagnosis_ns hsa-mir-126 Coronary Artery Disease 25349183 "In contrast, increased expression of miR-126 and miR-199a in circulating MVs was significantly associated with a lower major adverse CV event rate." -circulation_biomarker_diagnosis_ns hsa-mir-24 Heart Failure 25364765 miR-24 and miR-214 are bi-functional cardio-miRs. -circulation_biomarker_diagnosis_ns hsa-mir-29 Glioma 25367878 Identification and Evaluation of Serum MicroRNA-29 Family for Glioma Screening. -circulation_biomarker_diagnosis_ns hsa-mir-19a Acute Myocardial Infarction 25383678 Circulating microRNA-19a as a potential novel biomarker for diagnosis of acute myocardial infarction. -circulation_biomarker_diagnosis_ns hsa-mir-17 "Carcinoma, Hepatocellular" 25391771 "miR-30c-5p, miR-223-3p, miR-302c-3p and miR-17-8p could be used as novel non-invasive biomarkers of HCV-positive HCC in very early, even at cirrhosis stage of liver disease." -circulation_biomarker_diagnosis_ns hsa-mir-206 "Carcinoma, Hepatocellular" 25391771 "miR-30c-5p, miR-223-3p, miR-302c-3p and miR-17-9p could be used as novel non-invasive biomarkers of HCV-positive HCC in very early, even at cirrhosis stage of liver disease." -circulation_biomarker_diagnosis_ns hsa-mir-223 "Carcinoma, Hepatocellular" 25391771 "miR-30c-5p, miR-223-3p, miR-302c-3p and miR-17-6p could be used as novel non-invasive biomarkers of HCV-positive HCC in very early, even at cirrhosis stage of liver disease." -circulation_biomarker_diagnosis_ns hsa-mir-302c "Carcinoma, Hepatocellular" 25391771 "miR-30c-5p, miR-223-3p, miR-302c-3p and miR-17-7p could be used as novel non-invasive biomarkers of HCV-positive HCC in very early, even at cirrhosis stage of liver disease." -circulation_biomarker_diagnosis_ns hsa-mir-30c "Carcinoma, Hepatocellular" 25391771 "miR-30c-5p, miR-223-3p, miR-302c-3p and miR-17-5p could be used as novel non-invasive biomarkers of HCV-positive HCC in very early, even at cirrhosis stage of liver disease." -circulation_biomarker_diagnosis_ns hsa-mir-142 Systemic Lupus Erythematosus 25399392 "Circulating miRNA profiles are characteristic for SSc compared with both HC and SLE cases. Some of the predicted targets of the differentially regulated miRNA are of relevance for transforming growth factor-¦Â signaling andfibrosis, but need to be validated in independent studies." -circulation_biomarker_diagnosis_ns hsa-mir-150 Systemic Lupus Erythematosus 25399392 "Circulating miRNA profiles are characteristic for SSc compared with both HC and SLE cases. Some of the predicted targets of the differentially regulated miRNA are of relevance for transforming growth factor-¦Â signaling andfibrosis, but need to be validated in independent studies." -circulation_biomarker_diagnosis_ns hsa-mir-16 Systemic Lupus Erythematosus 25399392 "Circulating miRNA profiles are characteristic for SSc compared with both HC and SLE cases. Some of the predicted targets of the differentially regulated miRNA are of relevance for transforming growth factor-¦Â signaling andfibrosis, but need to be validated in independent studies." -circulation_biomarker_diagnosis_ns hsa-mir-223 Systemic Lupus Erythematosus 25399392 "Circulating miRNA profiles are characteristic for SSc compared with both HC and SLE cases. Some of the predicted targets of the differentially regulated miRNA are of relevance for transforming growth factor-¦Â signaling andfibrosis, but need to be validated in independent studies." -circulation_biomarker_diagnosis_ns hsa-mir-638 Systemic Lupus Erythematosus 25399392 "Circulating miRNA profiles are characteristic for SSc compared with both HC and SLE cases. Some of the predicted targets of the differentially regulated miRNA are of relevance for transforming growth factor-¦Â signaling andfibrosis, but need to be validated in independent studies." -circulation_biomarker_diagnosis_ns hsa-mir-125b Colorectal Carcinoma 25405754 "The measured levels of miRNAs in serum and plasma from same patients varied in the presence of hemolysis, and since hemolysis and other factors affected miRNA expression, it is important to consider these confounders while developing miRNA-based diagnostic assays." -circulation_biomarker_diagnosis_ns hsa-mir-16 Colorectal Carcinoma 25405754 "The measured levels of miRNAs in serum and plasma from same patients varied in the presence of hemolysis, and since hemolysis and other factors affected miRNA expression, it is important to consider these confounders while developing miRNA-based diagnostic assays." -circulation_biomarker_diagnosis_ns hsa-mir-21 Colorectal Carcinoma 25405754 "The measured levels of miRNAs in serum and plasma from same patients varied in the presence of hemolysis, and since hemolysis and other factors affected miRNA expression, it is important to consider these confounders while developing miRNA-based diagnostic assays." -circulation_biomarker_diagnosis_ns hsa-mir-29a Colorectal Carcinoma 25405754 "The measured levels of miRNAs in serum and plasma from same patients varied in the presence of hemolysis, and since hemolysis and other factors affected miRNA expression, it is important to consider these confounders while developing miRNA-based diagnostic assays." -circulation_biomarker_diagnosis_ns hsa-mir-124 Neoplasms [unspecific] 25416717 "This study describes a pipeline for robust diagnostic serum miRNA profiling in childhood solid tumors, and has identified candidate miRNA profiles for prospective testing." -circulation_biomarker_diagnosis_ns hsa-mir-1538 Neoplasms [unspecific] 25416717 "This study describes a pipeline for robust diagnostic serum miRNA profiling in childhood solid tumors, and has identified candidate miRNA profiles for prospective testing." -circulation_biomarker_diagnosis_ns hsa-mir-218 Neoplasms [unspecific] 25416717 "This study describes a pipeline for robust diagnostic serum miRNA profiling in childhood solid tumors, and has identified candidate miRNA profiles for prospective testing." -circulation_biomarker_diagnosis_ns hsa-mir-490 Neoplasms [unspecific] 25416717 "This study describes a pipeline for robust diagnostic serum miRNA profiling in childhood solid tumors, and has identified candidate miRNA profiles for prospective testing." -circulation_biomarker_diagnosis_ns hsa-mir-9 Neoplasms [unspecific] 25416717 "This study describes a pipeline for robust diagnostic serum miRNA profiling in childhood solid tumors, and has identified candidate miRNA profiles for prospective testing." -circulation_biomarker_diagnosis_ns hsa-mir-1179 Proliferative Diabetic Retinopathy 25427542 "serum miRNAs have the potential to be sensitive, cost-effective biomarkers for the early detection of PDR. These biomarkers could serve as a dynamic monitoring factor for detecting the progression of PDR from NPDR." -circulation_biomarker_diagnosis_ns hsa-mir-181c Proliferative Diabetic Retinopathy 25427542 "serum miRNAs have the potential to be sensitive, cost-effective biomarkers for the early detection of PDR. These biomarkers could serve as a dynamic monitoring factor for detecting the progression of PDR from NPDR." -circulation_biomarker_diagnosis_ns hsa-mir-21 Proliferative Diabetic Retinopathy 25427542 "serum miRNAs have the potential to be sensitive, cost-effective biomarkers for the early detection of PDR. These biomarkers could serve as a dynamic monitoring factor for detecting the progression of PDR from NPDR." -circulation_biomarker_diagnosis_ns hsa-mir-320a Macroglobulinemia 25428891 Combination of serum microRNA-320a and microRNA-320b as a marker for Waldenstr?m macroglobulinemia. -circulation_biomarker_diagnosis_ns hsa-mir-320b Macroglobulinemia 25428891 Combination of serum microRNA-320a and microRNA-321b as a marker for Waldenstr?m macroglobulinemia. -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Breast" 25431259 "MiR-21 has a relatively high diagnostic value for detecting breast cancer, and miR-21 assays based on plasma, serum, and tissue achieved relatively higher accuracy" -circulation_biomarker_diagnosis_ns hsa-mir-21 Neoplasms [unspecific] 25431259 "MiR-21 has a relatively high diagnostic value for detecting breast cancer, and miR-21 assays based on plasma, serum, and tissue achieved relatively higher accuracy" -circulation_biomarker_diagnosis_ns hsa-mir-505 Hypertension 25449503 "hsa-mir-505 is a novel circulating signature of hypertension, which may play a role in angiogenesis. Our results provide mechanistic insights into hypertension-associated pathogenesis and point " -circulation_biomarker_diagnosis_ns hsa-mir-122 Hepatitis B Virus Infection 25452043 Serum microRNA levels reflect differences in the etiology and stage of viral hepatitis. -circulation_biomarker_diagnosis_ns hsa-mir-125b Hepatitis B Virus Infection 25452043 Serum microRNA levels reflect differences in the etiology and stage of viral hepatitis. -circulation_biomarker_diagnosis_ns hsa-mir-1275 Hepatitis B Virus Infection 25452043 Serum microRNA levels reflect differences in the etiology and stage of viral hepatitis. -circulation_biomarker_diagnosis_ns hsa-mir-22 Hepatitis B Virus Infection 25452043 Serum microRNA levels reflect differences in the etiology and stage of viral hepatitis. -circulation_biomarker_diagnosis_ns hsa-mir-720 Hepatitis B Virus Infection 25452043 Serum microRNA levels reflect differences in the etiology and stage of viral hepatitis. -circulation_biomarker_diagnosis_ns hsa-mir-99a Hepatitis B Virus Infection 25452043 Serum microRNA levels reflect differences in the etiology and stage of viral hepatitis. -circulation_biomarker_diagnosis_ns hsa-mir-146b Thyroid Neoplasms 25456009 miR-146b and miR-155 helped to discriminate between benign and malignant lesions. Circulating miRNA is likely a useful alternate serological marker for PTC. This preliminary study suggested that circulating miRNAs may be useful as follow-up tools as well as diagnostic tools. -circulation_biomarker_diagnosis_ns hsa-mir-155 Thyroid Neoplasms 25456009 miR-146b and miR-155 helped to discriminate between benign and malignant lesions. Circulating miRNA is likely a useful alternate serological marker for PTC. This preliminary study suggested that circulating miRNAs may be useful as follow-up tools as well as diagnostic tools. -circulation_biomarker_diagnosis_ns hsa-mir-29 Endomyocardial Fibrosis 25457410 "Reply: MicroRNA-29, a mysterious regulator in myocardial fibrosis and circulating miR-29a as a biomarker." -circulation_biomarker_diagnosis_ns hsa-mir-21 Glomerulonephritis 25468389 "Furthermore, the glomerular and serum levels of miR-21, a putative microRNA ligand of TLR8, were higher in BXSB-Yaa mice than in BXSB mice." -circulation_biomarker_diagnosis_ns hsa-mir-150 Intrahepatic Cholangiocarcinoma 25482320 "combination of these two markers improved the power of screening ICC. Moreover, on the basis of the plasma miR-150 level, 15 ICC patients were divided into a low or high expression group. We found that plasma miR-150 is a potential diagnostic biomarker for ICC." -circulation_biomarker_diagnosis_ns hsa-mir-196a Oral Neoplasms 25485932 Combined determination of circulating miR-196a and miR-196b levels may serve as panel plasma biomarkers for the early detection of oral cancer. -circulation_biomarker_diagnosis_ns hsa-mir-196b Oral Neoplasms 25485932 Combined determination of circulating miR-196a and miR-196b levels may serve as panel plasma biomarkers for the early detection of oral cancer. -circulation_biomarker_diagnosis_ns hsa-mir-132 Schizophrenia 25487174 "miRNA expression is more significant in plasma than in PBMC, and suggest that miR-30e in plasma may be a more sensitive biomarker for schizophrenia diagnosis, although its aberrant expression can be detected in both plasma and PBMC." -circulation_biomarker_diagnosis_ns hsa-mir-181b Schizophrenia 25487174 "miRNA expression is more significant in plasma than in PBMC, and suggest that miR-30e in plasma may be a more sensitive biomarker for schizophrenia diagnosis, although its aberrant expression can be detected in both plasma and PBMC." -circulation_biomarker_diagnosis_ns hsa-mir-195 Schizophrenia 25487174 "miRNA expression is more significant in plasma than in PBMC, and suggest that miR-30e in plasma may be a more sensitive biomarker for schizophrenia diagnosis, although its aberrant expression can be detected in both plasma and PBMC." -circulation_biomarker_diagnosis_ns hsa-mir-212 Schizophrenia 25487174 "miRNA expression is more significant in plasma than in PBMC, and suggest that miR-30e in plasma may be a more sensitive biomarker for schizophrenia diagnosis, although its aberrant expression can be detected in both plasma and PBMC." -circulation_biomarker_diagnosis_ns hsa-mir-30e Schizophrenia 25487174 "miRNA expression is more significant in plasma than in PBMC, and suggest that miR-30e in plasma may be a more sensitive biomarker for schizophrenia diagnosis, although its aberrant expression can be detected in both plasma and PBMC." -circulation_biomarker_diagnosis_ns hsa-mir-346 Schizophrenia 25487174 "miRNA expression is more significant in plasma than in PBMC, and suggest that miR-30e in plasma may be a more sensitive biomarker for schizophrenia diagnosis, although its aberrant expression can be detected in both plasma and PBMC." -circulation_biomarker_diagnosis_ns hsa-mir-34a Schizophrenia 25487174 "miRNA expression is more significant in plasma than in PBMC, and suggest that miR-30e in plasma may be a more sensitive biomarker for schizophrenia diagnosis, although its aberrant expression can be detected in both plasma and PBMC." -circulation_biomarker_diagnosis_ns hsa-mir-432 Schizophrenia 25487174 "miRNA expression is more significant in plasma than in PBMC, and suggest that miR-30e in plasma may be a more sensitive biomarker for schizophrenia diagnosis, although its aberrant expression can be detected in both plasma and PBMC." -circulation_biomarker_diagnosis_ns hsa-mir-7 Schizophrenia 25487174 "miRNA expression is more significant in plasma than in PBMC, and suggest that miR-30e in plasma may be a more sensitive biomarker for schizophrenia diagnosis, although its aberrant expression can be detected in both plasma and PBMC." -circulation_biomarker_diagnosis_ns hsa-mir-148a Lung Neoplasms 25501703 miRNAs have great potential to serve as promising novel biomarkers in NSCLC screening. Further large-scale studies are needed to validate our results. -circulation_biomarker_diagnosis_ns hsa-mir-148b Lung Neoplasms 25501703 miRNAs have great potential to serve as promising novel biomarkers in NSCLC screening. Further large-scale studies are needed to validate our results. -circulation_biomarker_diagnosis_ns hsa-mir-152 Lung Neoplasms 25501703 miRNAs have great potential to serve as promising novel biomarkers in NSCLC screening. Further large-scale studies are needed to validate our results. -circulation_biomarker_diagnosis_ns hsa-mir-21 Lung Neoplasms 25501703 miRNAs have great potential to serve as promising novel biomarkers in NSCLC screening. Further large-scale studies are needed to validate our results. -circulation_biomarker_diagnosis_ns hsa-mir-377 "Leukemia, Myeloid, Acute" 25502508 a miRNA signature in human cord blood stem and progenitor cells with a potential role in hematopoietic stemness properties and possibly in leukemogenesis of specific AML subtypes. -circulation_biomarker_diagnosis_ns hsa-mir-4739 "Leukemia, Myeloid, Acute" 25502508 a miRNA signature in human cord blood stem and progenitor cells with a potential role in hematopoietic stemness properties and possibly in leukemogenesis of specific AML subtypes. -circulation_biomarker_diagnosis_ns hsa-mir-142 "Lymphoma, T-Cell" 25503151 miR profiling in CTCL may be a key to improving both diagnosis and risk prediction. -circulation_biomarker_diagnosis_ns hsa-mir-146b "Lymphoma, T-Cell" 25503151 miR profiling in CTCL may be a key to improving both diagnosis and risk prediction. -circulation_biomarker_diagnosis_ns hsa-mir-155 "Lymphoma, T-Cell" 25503151 miR profiling in CTCL may be a key to improving both diagnosis and risk prediction. -circulation_biomarker_diagnosis_ns hsa-mir-16 "Lymphoma, T-Cell" 25503151 miR profiling in CTCL may be a key to improving both diagnosis and risk prediction. -circulation_biomarker_diagnosis_ns hsa-mir-21 "Lymphoma, T-Cell" 25503151 miR profiling in CTCL may be a key to improving both diagnosis and risk prediction. -circulation_biomarker_diagnosis_ns hsa-mir-342 "Lymphoma, T-Cell" 25503151 miR profiling in CTCL may be a key to improving both diagnosis and risk prediction. -circulation_biomarker_diagnosis_ns hsa-mir-92a "Lymphoma, T-Cell" 25503151 miR profiling in CTCL may be a key to improving both diagnosis and risk prediction. -circulation_biomarker_diagnosis_ns hsa-mir-93 "Lymphoma, T-Cell" 25503151 miR profiling in CTCL may be a key to improving both diagnosis and risk prediction. -circulation_biomarker_diagnosis_ns hsa-mir-16 Chronic Hepatitis C 25505813 "the expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 target miRNAs in PBMCs of CHC may act as significant risk biomarkers for the development of CHC." -circulation_biomarker_diagnosis_ns hsa-mir-193b Chronic Hepatitis C 25505813 "the expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 target miRNAs in PBMCs of CHC may act as significant risk biomarkers for the development of CHC." -circulation_biomarker_diagnosis_ns hsa-mir-199a Chronic Hepatitis C 25505813 "the expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 target miRNAs in PBMCs of CHC may act as significant risk biomarkers for the development of CHC." -circulation_biomarker_diagnosis_ns hsa-mir-222 Chronic Hepatitis C 25505813 "the expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 target miRNAs in PBMCs of CHC may act as significant risk biomarkers for the development of CHC." -circulation_biomarker_diagnosis_ns hsa-mir-324 Chronic Hepatitis C 25505813 "the expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 target miRNAs in PBMCs of CHC may act as significant risk biomarkers for the development of CHC." -circulation_biomarker_diagnosis_ns hsa-mir-21 Breast Neoplasms 25516467 "miR-21 is a potential biomarker for early diagnosis of breast cancer with high sensitivity and specificity, and its clinical application warrants further investigation" -circulation_biomarker_diagnosis_ns hsa-mir-200a "Carcinoma, Hepatocellular, HBV-Related" 25519019 "only in the HCC group, miR-18a, miR-100, miR-145 and miR-223 were up-regulated 3.48-, 2.95-, 2.12- and 3.91-fold, respectively, and miR-200a and miR-222 were down-regulated 2.56- and 2.00-fold, respectively." -circulation_biomarker_diagnosis_ns hsa-let-7c Prostate Neoplasms 25521481 the combination of the studied circulating plasma miRNAs and serum PSA has the potential to be used as a noninvasive diagnostic biomarker for PC screening outperforming the PSA testing alone. -circulation_biomarker_diagnosis_ns hsa-mir-141 Prostate Neoplasms 25521481 the combination of the studied circulating plasma miRNAs and serum PSA has the potential to be used as a noninvasive diagnostic biomarker for PC screening outperforming the PSA testing alone. -circulation_biomarker_diagnosis_ns hsa-mir-30c Prostate Neoplasms 25521481 the combination of the studied circulating plasma miRNAs and serum PSA has the potential to be used as a noninvasive diagnostic biomarker for PC screening outperforming the PSA testing alone. -circulation_biomarker_diagnosis_ns hsa-mir-375 Prostate Neoplasms 25521481 the combination of the studied circulating plasma miRNAs and serum PSA has the potential to be used as a noninvasive diagnostic biomarker for PC screening outperforming the PSA testing alone. -circulation_biomarker_diagnosis_ns hsa-mir-21 Colorectal Carcinoma 25524942 Circulating miR-21 may be a suitable diagnostic biomarker for CRC with moderate sensitivity and specificity. Further studies should evaluate the diagnostic value of miR-21 for CRC in the future. -circulation_biomarker_diagnosis_ns hsa-mir-21 Neoplasms [unspecific] 25527152 the circulating miR-21 may be a potential biomarker as diagnostic tool for early-stage cancer diagnosis. -circulation_biomarker_diagnosis_ns hsa-mir-182 "Diabetes Mellitus, Type 2" 25530976 miR-182 can be a biomarker in diagnosis of the potential T2D that has benefits for medical purpose. -circulation_biomarker_diagnosis_ns hsa-mir-192 Prediabetes 25532038 "the pattern of circulating miRNAs is modified by defects in glucose metabolism in a similar manner in mice and humans. This circulating miRNA signature for prediabetes could be used as a new diagnostic tool, as well as to monitor response to intervention." -circulation_biomarker_diagnosis_ns hsa-mir-193b Prediabetes 25532038 "the pattern of circulating miRNAs is modified by defects in glucose metabolism in a similar manner in mice and humans. This circulating miRNA signature for prediabetes could be used as a new diagnostic tool, as well as to monitor response to intervention." -circulation_biomarker_diagnosis_ns hsa-mir-16 Multiple Myeloma 25593199 A serum microRNA signature associated with complete remission and progression after autologous stem-cell transplantation in patients with multiple myeloma. -circulation_biomarker_diagnosis_ns hsa-mir-17 Multiple Myeloma 25593199 A serum microRNA signature associated with complete remission and progression after autologous stem-cell transplantation in patients with multiple myeloma. -circulation_biomarker_diagnosis_ns hsa-mir-19b Multiple Myeloma 25593199 A serum microRNA signature associated with complete remission and progression after autologous stem-cell transplantation in patients with multiple myeloma. -circulation_biomarker_diagnosis_ns hsa-mir-20a Multiple Myeloma 25593199 A serum microRNA signature associated with complete remission and progression after autologous stem-cell transplantation in patients with multiple myeloma. -circulation_biomarker_diagnosis_ns hsa-mir-25 Multiple Myeloma 25593199 A serum microRNA signature associated with complete remission and progression after autologous stem-cell transplantation in patients with multiple myeloma. -circulation_biomarker_diagnosis_ns hsa-mir-331 Multiple Myeloma 25593199 A serum microRNA signature associated with complete remission and progression after autologous stem-cell transplantation in patients with multiple myeloma. -circulation_biomarker_diagnosis_ns hsa-mir-660 Multiple Myeloma 25593199 A serum microRNA signature associated with complete remission and progression after autologous stem-cell transplantation in patients with multiple myeloma. -circulation_biomarker_diagnosis_ns hsa-mir-199a "Carcinoma, Hepatocellular" 25618599 "circulating miR-199a-3p showed better predictive value in patients with long-term drinking. Our data suggested that circulating miR-375 and miR-199a-3p could be a novel serum biomarker for HCC. Nevertheless, further validating and improving study with larger sample should be conducted to confirm our results." -circulation_biomarker_diagnosis_ns hsa-mir-375 "Carcinoma, Hepatocellular" 25618599 "circulating miR-199a-3p showed better predictive value in patients with long-term drinking. Our data suggested that circulating miR-375 and miR-199a-3p could be a novel serum biomarker for HCC. Nevertheless, further validating and improving study with larger sample should be conducted to confirm our results." -circulation_biomarker_diagnosis_ns hsa-mir-125a Heart Failure 25619197 "Of these, miR-1233, -183-3p, -190a, -193b-3p, -193b-5p, -211-5p, -494, and -671-5p distinguished HF from controls." -circulation_biomarker_diagnosis_ns hsa-mir-211 Heart Failure 25619197 "Of these, miR-1233, -183-3p, -190a, -193b-3p, -193b-5p, -211-5p, -494, and -671-5p distinguished HF from controls." -circulation_biomarker_diagnosis_ns hsa-let-7a "Carcinoma, Urothelial, Upper Tract" 25629698 MicroRNA expression is altered in UUTUC. The analysis of circulating miR-141 may be useful to identify patients with UUTUC. -circulation_biomarker_diagnosis_ns hsa-let-7b "Carcinoma, Urothelial, Upper Tract" 25629698 MicroRNA expression is altered in UUTUC. The analysis of circulating miR-141 may be useful to identify patients with UUTUC. -circulation_biomarker_diagnosis_ns hsa-let-7c "Carcinoma, Urothelial, Upper Tract" 25629698 MicroRNA expression is altered in UUTUC. The analysis of circulating miR-141 may be useful to identify patients with UUTUC. -circulation_biomarker_diagnosis_ns hsa-let-7f "Carcinoma, Urothelial, Upper Tract" 25629698 MicroRNA expression is altered in UUTUC. The analysis of circulating miR-141 may be useful to identify patients with UUTUC. -circulation_biomarker_diagnosis_ns hsa-mir-10a "Carcinoma, Urothelial, Upper Tract" 25629698 MicroRNA expression is altered in UUTUC. The analysis of circulating miR-141 may be useful to identify patients with UUTUC. -circulation_biomarker_diagnosis_ns hsa-mir-1244 "Carcinoma, Urothelial, Upper Tract" 25629698 MicroRNA expression is altered in UUTUC. The analysis of circulating miR-141 may be useful to identify patients with UUTUC. -circulation_biomarker_diagnosis_ns hsa-mir-135 "Carcinoma, Urothelial, Upper Tract" 25629698 MicroRNA expression is altered in UUTUC. The analysis of circulating miR-141 may be useful to identify patients with UUTUC. -circulation_biomarker_diagnosis_ns hsa-mir-141 "Carcinoma, Urothelial, Upper Tract" 25629698 MicroRNA expression is altered in UUTUC. The analysis of circulating miR-141 may be useful to identify patients with UUTUC. -circulation_biomarker_diagnosis_ns hsa-mir-16 "Carcinoma, Urothelial, Upper Tract" 25629698 MicroRNA expression is altered in UUTUC. The analysis of circulating miR-141 may be useful to identify patients with UUTUC. -circulation_biomarker_diagnosis_ns hsa-mir-182 "Carcinoma, Urothelial, Upper Tract" 25629698 MicroRNA expression is altered in UUTUC. The analysis of circulating miR-141 may be useful to identify patients with UUTUC. -circulation_biomarker_diagnosis_ns hsa-mir-200b "Carcinoma, Urothelial, Upper Tract" 25629698 MicroRNA expression is altered in UUTUC. The analysis of circulating miR-141 may be useful to identify patients with UUTUC. -circulation_biomarker_diagnosis_ns hsa-mir-205 "Carcinoma, Urothelial, Upper Tract" 25629698 MicroRNA expression is altered in UUTUC. The analysis of circulating miR-141 may be useful to identify patients with UUTUC. -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Urothelial, Upper Tract" 25629698 MicroRNA expression is altered in UUTUC. The analysis of circulating miR-141 may be useful to identify patients with UUTUC. -circulation_biomarker_diagnosis_ns hsa-mir-429 "Carcinoma, Urothelial, Upper Tract" 25629698 MicroRNA expression is altered in UUTUC. The analysis of circulating miR-141 may be useful to identify patients with UUTUC. -circulation_biomarker_diagnosis_ns hsa-mir-520b "Carcinoma, Urothelial, Upper Tract" 25629698 MicroRNA expression is altered in UUTUC. The analysis of circulating miR-141 may be useful to identify patients with UUTUC. -circulation_biomarker_diagnosis_ns hsa-mir-96 "Carcinoma, Urothelial, Upper Tract" 25629698 MicroRNA expression is altered in UUTUC. The analysis of circulating miR-141 may be useful to identify patients with UUTUC. -circulation_biomarker_diagnosis_ns hsa-mir-143 Obesity 25637573 Obesity leads to alterations in miRNA expressions and miRNA-143 and -223s can be used as biomarkers for the metabolic changes in obesity. -circulation_biomarker_diagnosis_ns hsa-mir-223 Obesity 25637573 Obesity leads to alterations in miRNA expressions and miRNA-143 and -223s can be used as biomarkers for the metabolic changes in obesity. -circulation_biomarker_diagnosis_ns hsa-mir-125a Lung Neoplasms 25639977 the panel of miRNA biomarkers had the potential for the early detection of lung cancer. -circulation_biomarker_diagnosis_ns hsa-mir-126 Lung Neoplasms 25639977 the panel of miRNA biomarkers had the potential for the early detection of lung cancer. -circulation_biomarker_diagnosis_ns hsa-mir-25 Lung Neoplasms 25639977 the panel of miRNA biomarkers had the potential for the early detection of lung cancer. -circulation_biomarker_diagnosis_ns hsa-mir-132 Schizophrenia 25656957 A preliminary analysis of microRNA as potential clinical biomarker for schizophrenia. -circulation_biomarker_diagnosis_ns hsa-mir-181b Schizophrenia 25656957 A preliminary analysis of microRNA as potential clinical biomarker for schizophrenia. -circulation_biomarker_diagnosis_ns hsa-mir-212 Schizophrenia 25656957 A preliminary analysis of microRNA as potential clinical biomarker for schizophrenia. -circulation_biomarker_diagnosis_ns hsa-mir-30e Schizophrenia 25656957 A preliminary analysis of microRNA as potential clinical biomarker for schizophrenia. -circulation_biomarker_diagnosis_ns hsa-mir-346 Schizophrenia 25656957 A preliminary analysis of microRNA as potential clinical biomarker for schizophrenia. -circulation_biomarker_diagnosis_ns hsa-mir-432 Schizophrenia 25656957 A preliminary analysis of microRNA as potential clinical biomarker for schizophrenia. -circulation_biomarker_diagnosis_ns hsa-mir-149 Coronary Artery Disease 25664324 Circulating miR-765 and miR-149: potential noninvasive diagnostic biomarkers for geriatric coronary artery disease patients. -circulation_biomarker_diagnosis_ns hsa-mir-765 Coronary Artery Disease 25664324 Circulating miR-765 and miR-149: potential noninvasive diagnostic biomarkers for geriatric coronary artery disease patients. -circulation_biomarker_diagnosis_ns hsa-mir-223 Allergic Rhinitis 25675113 Serum hsa-miR-223 was significantly up-regulated in postseason compared with preseason samples. -circulation_biomarker_diagnosis_ns hsa-mir-103 "Diabetes Mellitus, Type 2" 25677225 "This meta-analysis confirms that 40 miRNAs are significantly dysregulated in type 2 diabetes. miR-29a, miR-34a, miR-375,miR-103, miR-107, miR-132, miR-142-3p and miR-144 are potential circulating biomarkers of type 2 diabetes. In addition, miR-199a-3p and miR-223 are potential tissue biomarkers of type 2 diabetes." -circulation_biomarker_diagnosis_ns hsa-mir-107 "Diabetes Mellitus, Type 2" 25677225 "This meta-analysis confirms that 40 miRNAs are significantly dysregulated in type 2 diabetes. miR-29a, miR-34a, miR-375,miR-103, miR-107, miR-132, miR-142-3p and miR-144 are potential circulating biomarkers of type 2 diabetes. In addition, miR-199a-3p and miR-223 are potential tissue biomarkers of type 2 diabetes." -circulation_biomarker_diagnosis_ns hsa-mir-132 "Diabetes Mellitus, Type 2" 25677225 "This meta-analysis confirms that 40 miRNAs are significantly dysregulated in type 2 diabetes. miR-29a, miR-34a, miR-375,miR-103, miR-107, miR-132, miR-142-3p and miR-144 are potential circulating biomarkers of type 2 diabetes. In addition, miR-199a-3p and miR-223 are potential tissue biomarkers of type 2 diabetes." -circulation_biomarker_diagnosis_ns hsa-mir-142 "Diabetes Mellitus, Type 2" 25677225 "This meta-analysis confirms that 40 miRNAs are significantly dysregulated in type 2 diabetes. miR-29a, miR-34a, miR-375,miR-103, miR-107, miR-132, miR-142-3p and miR-144 are potential circulating biomarkers of type 2 diabetes. In addition, miR-199a-3p and miR-223 are potential tissue biomarkers of type 2 diabetes." -circulation_biomarker_diagnosis_ns hsa-mir-144 "Diabetes Mellitus, Type 2" 25677225 "This meta-analysis confirms that 40 miRNAs are significantly dysregulated in type 2 diabetes. miR-29a, miR-34a, miR-375,miR-103, miR-107, miR-132, miR-142-3p and miR-144 are potential circulating biomarkers of type 2 diabetes. In addition, miR-199a-3p and miR-223 are potential tissue biomarkers of type 2 diabetes." -circulation_biomarker_diagnosis_ns hsa-mir-199a "Diabetes Mellitus, Type 2" 25677225 "This meta-analysis confirms that 40 miRNAs are significantly dysregulated in type 2 diabetes. miR-29a, miR-34a, miR-375,miR-103, miR-107, miR-132, miR-142-3p and miR-144 are potential circulating biomarkers of type 2 diabetes. In addition, miR-199a-3p and miR-223 are potential tissue biomarkers of type 2 diabetes." -circulation_biomarker_diagnosis_ns hsa-mir-223 "Diabetes Mellitus, Type 2" 25677225 "This meta-analysis confirms that 40 miRNAs are significantly dysregulated in type 2 diabetes. miR-29a, miR-34a, miR-375,miR-103, miR-107, miR-132, miR-142-3p and miR-144 are potential circulating biomarkers of type 2 diabetes. In addition, miR-199a-3p and miR-223 are potential tissue biomarkers of type 2 diabetes." -circulation_biomarker_diagnosis_ns hsa-mir-29a "Diabetes Mellitus, Type 2" 25677225 "This meta-analysis confirms that 40 miRNAs are significantly dysregulated in type 2 diabetes. miR-29a, miR-34a, miR-375,miR-103, miR-107, miR-132, miR-142-3p and miR-144 are potential circulating biomarkers of type 2 diabetes. In addition, miR-199a-3p and miR-223 are potential tissue biomarkers of type 2 diabetes." -circulation_biomarker_diagnosis_ns hsa-mir-30e "Diabetes Mellitus, Type 2" 25677225 "This meta-analysis confirms that 40 miRNAs are significantly dysregulated in type 2 diabetes. miR-29a, miR-34a, miR-375,miR-103, miR-107, miR-132, miR-142-3p and miR-144 are potential circulating biomarkers of type 2 diabetes. In addition, miR-199a-3p and miR-223 are potential tissue biomarkers of type 2 diabetes." -circulation_biomarker_diagnosis_ns hsa-mir-34a "Diabetes Mellitus, Type 2" 25677225 "This meta-analysis confirms that 40 miRNAs are significantly dysregulated in type 2 diabetes. miR-29a, miR-34a, miR-375,miR-103, miR-107, miR-132, miR-142-3p and miR-144 are potential circulating biomarkers of type 2 diabetes. In addition, miR-199a-3p and miR-223 are potential tissue biomarkers of type 2 diabetes." -circulation_biomarker_diagnosis_ns hsa-mir-375 "Diabetes Mellitus, Type 2" 25677225 "This meta-analysis confirms that 40 miRNAs are significantly dysregulated in type 2 diabetes. miR-29a, miR-34a, miR-375,miR-103, miR-107, miR-132, miR-142-3p and miR-144 are potential circulating biomarkers of type 2 diabetes. In addition, miR-199a-3p and miR-223 are potential tissue biomarkers of type 2 diabetes." -circulation_biomarker_diagnosis_ns hsa-mir-92a "Diabetes Mellitus, Type 2" 25677225 "This meta-analysis confirms that 40 miRNAs are significantly dysregulated in type 2 diabetes. miR-29a, miR-34a, miR-375,miR-103, miR-107, miR-132, miR-142-3p and miR-144 are potential circulating biomarkers of type 2 diabetes. In addition, miR-199a-3p and miR-223 are potential tissue biomarkers of type 2 diabetes." -circulation_biomarker_diagnosis_ns hsa-mir-1225 Focal Segmental Glomerulosclerosis 25682967 Patients with FSGS and minimal change disease (MCD) have a unique circulating and urinary miRNA profile. The diagnostic and prognostic potential of miRNAs in FSGS and minimal change disease (MCD) warrants further studies. -circulation_biomarker_diagnosis_ns hsa-mir-1915 Focal Segmental Glomerulosclerosis 25682967 Patients with FSGS and minimal change disease (MCD) have a unique circulating and urinary miRNA profile. The diagnostic and prognostic potential of miRNAs in FSGS and minimal change disease (MCD) warrants further studies. -circulation_biomarker_diagnosis_ns hsa-mir-30b Focal Segmental Glomerulosclerosis 25682967 Patients with FSGS and minimal change disease (MCD) have a unique circulating and urinary miRNA profile. The diagnostic and prognostic potential of miRNAs in FSGS and minimal change disease (MCD) warrants further studies. -circulation_biomarker_diagnosis_ns hsa-mir-30c Focal Segmental Glomerulosclerosis 25682967 Patients with FSGS and minimal change disease (MCD) have a unique circulating and urinary miRNA profile. The diagnostic and prognostic potential of miRNAs in FSGS and minimal change disease (MCD) warrants further studies. -circulation_biomarker_diagnosis_ns hsa-mir-342 Focal Segmental Glomerulosclerosis 25682967 Patients with FSGS and minimal change disease (MCD) have a unique circulating and urinary miRNA profile. The diagnostic and prognostic potential of miRNAs in FSGS and minimal change disease (MCD) warrants further studies. -circulation_biomarker_diagnosis_ns hsa-mir-34b Focal Segmental Glomerulosclerosis 25682967 Patients with FSGS and minimal change disease (MCD) have a unique circulating and urinary miRNA profile. The diagnostic and prognostic potential of miRNAs in FSGS and minimal change disease (MCD) warrants further studies. -circulation_biomarker_diagnosis_ns hsa-mir-34c Focal Segmental Glomerulosclerosis 25682967 Patients with FSGS and minimal change disease (MCD) have a unique circulating and urinary miRNA profile. The diagnostic and prognostic potential of miRNAs in FSGS and minimal change disease (MCD) warrants further studies. -circulation_biomarker_diagnosis_ns hsa-mir-663 Focal Segmental Glomerulosclerosis 25682967 Patients with FSGS and minimal change disease (MCD) have a unique circulating and urinary miRNA profile. The diagnostic and prognostic potential of miRNAs in FSGS and minimal change disease (MCD) warrants further studies. -circulation_biomarker_diagnosis_ns hsa-mir-21 Colorectal Carcinoma 25683351 The accuracy of circulating microRNA-21 in the diagnosis of colorectal cancer: a systematic review and meta-analysis. -circulation_biomarker_diagnosis_ns hsa-mir-127 "Carcinoma, Cervical" 25701838 Plasma miR-127 and miR-218 Might Serve as Potential Biomarkers for Cervical Cancer. -circulation_biomarker_diagnosis_ns hsa-mir-218 "Carcinoma, Cervical" 25701838 Plasma miR-127 and miR-218 Might Serve as Potential Biomarkers for Cervical Cancer. -circulation_biomarker_diagnosis_ns hsa-mir-28 Unstable Angina 25704294 "Our findings suggest that circulating miR-28-5p, involved in LXR¦Á-ABCA1 pathway, may be a potential biomarker for diagnosis and prognosis of unstable angina." -circulation_biomarker_diagnosis_ns hsa-mir-125a "Carcinoma, Biliary Tract" 25706130 Our results suggest that the assessment of these miRNA markers is clinically valuable to identify patients with pancreato-biliary cancers who could benefit from surgical intervention. -circulation_biomarker_diagnosis_ns hsa-mir-4294 "Carcinoma, Biliary Tract" 25706130 Our results suggest that the assessment of these miRNA markers is clinically valuable to identify patients with pancreato-biliary cancers who could benefit from surgical intervention. -circulation_biomarker_diagnosis_ns hsa-mir-4476 "Carcinoma, Biliary Tract" 25706130 Our results suggest that the assessment of these miRNA markers is clinically valuable to identify patients with pancreato-biliary cancers who could benefit from surgical intervention. -circulation_biomarker_diagnosis_ns hsa-mir-4530 "Carcinoma, Biliary Tract" 25706130 Our results suggest that the assessment of these miRNA markers is clinically valuable to identify patients with pancreato-biliary cancers who could benefit from surgical intervention. -circulation_biomarker_diagnosis_ns hsa-mir-6075 "Carcinoma, Biliary Tract" 25706130 Our results suggest that the assessment of these miRNA markers is clinically valuable to identify patients with pancreato-biliary cancers who could benefit from surgical intervention. -circulation_biomarker_diagnosis_ns hsa-mir-6799 "Carcinoma, Biliary Tract" 25706130 Our results suggest that the assessment of these miRNA markers is clinically valuable to identify patients with pancreato-biliary cancers who could benefit from surgical intervention. -circulation_biomarker_diagnosis_ns hsa-mir-6836 "Carcinoma, Biliary Tract" 25706130 Our results suggest that the assessment of these miRNA markers is clinically valuable to identify patients with pancreato-biliary cancers who could benefit from surgical intervention. -circulation_biomarker_diagnosis_ns hsa-mir-6880 "Carcinoma, Biliary Tract" 25706130 Our results suggest that the assessment of these miRNA markers is clinically valuable to identify patients with pancreato-biliary cancers who could benefit from surgical intervention. -circulation_biomarker_diagnosis_ns hsa-mir-21 Allergic Asthma 25707810 Serum MicroRNA-21 as a Biomarker for Allergic Inflammatory Disease in Children. -circulation_biomarker_diagnosis_ns hsa-mir-145 Ovarian Neoplasms 25722112 Serum microRNA-145 as a novel biomarker in human ovarian cancer. -circulation_biomarker_diagnosis_ns hsa-mir-100 Breast Neoplasms 25722304 These results point to using high levels of tRNA-derived small RNA fragments in combination with known miR signatures of tumors to distinguish tumor-derived EVs in circulation from EVs derived from other cell sources. Such biomarkers would be unique to the EVs where high abundances of tRNA fragments are amplified with respect to their cellular levels. -circulation_biomarker_diagnosis_ns hsa-let-7d Hyperactivity Disorder 25724585 Circulating MicroRNA Let-7d in Attention-Deficit/Hyperactivity Disorder. -circulation_biomarker_diagnosis_ns hsa-mir-92a Colorectal Carcinoma 25736690 All 3 miRNAs studied were positively inter-correlated. -circulation_biomarker_diagnosis_ns hsa-mir-196a Chronic Hepatitis C 25738504 Circulating microRNA-196a as a candidate diagnostic biomarker for chronic hepatitis C. -circulation_biomarker_diagnosis_ns hsa-mir-126 Preeclampsia 25738738 "the miRNAs identified in this study as being abnormally expressed in PE, may be useful as non-invasive diagnostic biomarkers. Co-regulated mRNAs and possible causal pathways involved in the pathogenesis of PE were also identified." -circulation_biomarker_diagnosis_ns hsa-mir-130a Preeclampsia 25738738 "the miRNAs identified in this study as being abnormally expressed in PE, may be useful as non-invasive diagnostic biomarkers. Co-regulated mRNAs and possible causal pathways involved in the pathogenesis of PE were also identified." -circulation_biomarker_diagnosis_ns hsa-mir-135b Preeclampsia 25738738 "the miRNAs identified in this study as being abnormally expressed in PE, may be useful as non-invasive diagnostic biomarkers. Co-regulated mRNAs and possible causal pathways involved in the pathogenesis of PE were also identified." -circulation_biomarker_diagnosis_ns hsa-mir-142 Preeclampsia 25738738 "the miRNAs identified in this study as being abnormally expressed in PE, may be useful as non-invasive diagnostic biomarkers. Co-regulated mRNAs and possible causal pathways involved in the pathogenesis of PE were also identified." -circulation_biomarker_diagnosis_ns hsa-mir-149 Preeclampsia 25738738 "the miRNAs identified in this study as being abnormally expressed in PE, may be useful as non-invasive diagnostic biomarkers. Co-regulated mRNAs and possible causal pathways involved in the pathogenesis of PE were also identified." -circulation_biomarker_diagnosis_ns hsa-mir-188 Preeclampsia 25738738 "the miRNAs identified in this study as being abnormally expressed in PE, may be useful as non-invasive diagnostic biomarkers. Co-regulated mRNAs and possible causal pathways involved in the pathogenesis of PE were also identified." -circulation_biomarker_diagnosis_ns hsa-mir-18a Preeclampsia 25738738 "the miRNAs identified in this study as being abnormally expressed in PE, may be useful as non-invasive diagnostic biomarkers. Co-regulated mRNAs and possible causal pathways involved in the pathogenesis of PE were also identified." -circulation_biomarker_diagnosis_ns hsa-mir-18b Preeclampsia 25738738 "the miRNAs identified in this study as being abnormally expressed in PE, may be useful as non-invasive diagnostic biomarkers. Co-regulated mRNAs and possible causal pathways involved in the pathogenesis of PE were also identified." -circulation_biomarker_diagnosis_ns hsa-mir-203 Preeclampsia 25738738 "the miRNAs identified in this study as being abnormally expressed in PE, may be useful as non-invasive diagnostic biomarkers. Co-regulated mRNAs and possible causal pathways involved in the pathogenesis of PE were also identified." -circulation_biomarker_diagnosis_ns hsa-mir-205 Preeclampsia 25738738 "the miRNAs identified in this study as being abnormally expressed in PE, may be useful as non-invasive diagnostic biomarkers. Co-regulated mRNAs and possible causal pathways involved in the pathogenesis of PE were also identified." -circulation_biomarker_diagnosis_ns hsa-mir-224 Preeclampsia 25738738 "the miRNAs identified in this study as being abnormally expressed in PE, may be useful as non-invasive diagnostic biomarkers. Co-regulated mRNAs and possible causal pathways involved in the pathogenesis of PE were also identified." -circulation_biomarker_diagnosis_ns hsa-mir-27a Preeclampsia 25738738 "the miRNAs identified in this study as being abnormally expressed in PE, may be useful as non-invasive diagnostic biomarkers. Co-regulated mRNAs and possible causal pathways involved in the pathogenesis of PE were also identified." -circulation_biomarker_diagnosis_ns hsa-mir-29a Preeclampsia 25738738 "the miRNAs identified in this study as being abnormally expressed in PE, may be useful as non-invasive diagnostic biomarkers. Co-regulated mRNAs and possible causal pathways involved in the pathogenesis of PE were also identified." -circulation_biomarker_diagnosis_ns hsa-mir-301a Preeclampsia 25738738 "the miRNAs identified in this study as being abnormally expressed in PE, may be useful as non-invasive diagnostic biomarkers. Co-regulated mRNAs and possible causal pathways involved in the pathogenesis of PE were also identified." -circulation_biomarker_diagnosis_ns hsa-mir-517c Preeclampsia 25738738 "the miRNAs identified in this study as being abnormally expressed in PE, may be useful as non-invasive diagnostic biomarkers. Co-regulated mRNAs and possible causal pathways involved in the pathogenesis of PE were also identified." -circulation_biomarker_diagnosis_ns hsa-mir-518 Preeclampsia 25738738 "the miRNAs identified in this study as being abnormally expressed in PE, may be useful as non-invasive diagnostic biomarkers. Co-regulated mRNAs and possible causal pathways involved in the pathogenesis of PE were also identified." -circulation_biomarker_diagnosis_ns hsa-mir-518e Preeclampsia 25738738 "the miRNAs identified in this study as being abnormally expressed in PE, may be useful as non-invasive diagnostic biomarkers. Co-regulated mRNAs and possible causal pathways involved in the pathogenesis of PE were also identified." -circulation_biomarker_diagnosis_ns hsa-mir-519d Preeclampsia 25738738 "the miRNAs identified in this study as being abnormally expressed in PE, may be useful as non-invasive diagnostic biomarkers. Co-regulated mRNAs and possible causal pathways involved in the pathogenesis of PE were also identified." -circulation_biomarker_diagnosis_ns hsa-mir-93 Preeclampsia 25738738 "the miRNAs identified in this study as being abnormally expressed in PE, may be useful as non-invasive diagnostic biomarkers. Co-regulated mRNAs and possible causal pathways involved in the pathogenesis of PE were also identified." -circulation_biomarker_diagnosis_ns hsa-mir-146a Heart Failure 25739750 "This study has shown for the first time that various miRNA combinations are useful biomarkers for HF, and also in the differentiation of HFpEF from HFrEF. The utility of these biomarker combinations can be altered by inclusion of natriuretic peptide. MiRNA biomarkers may support diagnostic strategies in subpopulations of patients with HF." -circulation_biomarker_diagnosis_ns hsa-mir-221 Heart Failure 25739750 "This study has shown for the first time that various miRNA combinations are useful biomarkers for HF, and also in the differentiation of HFpEF from HFrEF. The utility of these biomarker combinations can be altered by inclusion of natriuretic peptide. MiRNA biomarkers may support diagnostic strategies in subpopulations of patients with HF." -circulation_biomarker_diagnosis_ns hsa-mir-30c Heart Failure 25739750 "This study has shown for the first time that various miRNA combinations are useful biomarkers for HF, and also in the differentiation of HFpEF from HFrEF. The utility of these biomarker combinations can be altered by inclusion of natriuretic peptide. MiRNA biomarkers may support diagnostic strategies in subpopulations of patients with HF." -circulation_biomarker_diagnosis_ns hsa-mir-328 Heart Failure 25739750 "This study has shown for the first time that various miRNA combinations are useful biomarkers for HF, and also in the differentiation of HFpEF from HFrEF. The utility of these biomarker combinations can be altered by inclusion of natriuretic peptide. MiRNA biomarkers may support diagnostic strategies in subpopulations of patients with HF." -circulation_biomarker_diagnosis_ns hsa-mir-375 Heart Failure 25739750 "This study has shown for the first time that various miRNA combinations are useful biomarkers for HF, and also in the differentiation of HFpEF from HFrEF. The utility of these biomarker combinations can be altered by inclusion of natriuretic peptide. MiRNA biomarkers may support diagnostic strategies in subpopulations of patients with HF." -circulation_biomarker_diagnosis_ns hsa-mir-155 Male Infertility 25740880 Serum miR-155 as a potential biomarker of male fertility. -circulation_biomarker_diagnosis_ns hsa-mir-100 Acute Coronary Syndrome 25744750 Plasma microRNA-100 as a biomarker of coronary plaque vulnerability ¨C a new generation of biomarker for developing acute coronary syndrome. -circulation_biomarker_diagnosis_ns hsa-mir-93 Tuberculosis 25753045 Identification of miR-93 as a suitable miR for normalizing miRNA in plasma of tuberculosis patients. -circulation_biomarker_diagnosis_ns hsa-mir-375 Prostate Neoplasms 25754273 The combined serum levels of miR-375 and urokinase plasminogen activator receptor are suggested as diagnostic and prognostic biomarkers in prostate cancer. -circulation_biomarker_diagnosis_ns hsa-mir-125a "Carcinoma, Lung, Non-Small-Cell" 25755772 "These preliminary data suggest that serum miR-125a-5p, miR-145 and miR-146a may be useful noninvasive biomarkers for the clinical diagnosis of NSCLC." -circulation_biomarker_diagnosis_ns hsa-mir-145 "Carcinoma, Lung, Non-Small-Cell" 25755772 "These preliminary data suggest that serum miR-125a-5p, miR-145 and miR-146a may be useful noninvasive biomarkers for the clinical diagnosis of NSCLC." -circulation_biomarker_diagnosis_ns hsa-mir-146a "Carcinoma, Lung, Non-Small-Cell" 25755772 "These preliminary data suggest that serum miR-125a-5p, miR-145 and miR-146a may be useful noninvasive biomarkers for the clinical diagnosis of NSCLC." -circulation_biomarker_diagnosis_ns hsa-mir-210 Glioma 25756397 Serum miR-210 is a promising diagnostic and prognostic biomarker that can be detected in the peripheral blood of patients with glioma. -circulation_biomarker_diagnosis_ns hsa-let-7b Heart Failure 25763857 "Measured microRNA profiles did not separate the samples according to the clinical features of the patients. However, several previously identified heart failure marker microRNAs were detected. The pericardial fluid microRNA profile appeared to be a result of an active and selective secretory process indicating that microRNAs may act as paracrine signalling factors by mediating the local crosstalk between cardiac cells." -circulation_biomarker_diagnosis_ns hsa-mir-31 Lung Neoplasms 25765717 miRNA-31 may be a molecular marker for the diagnostic and prognostic evaluation of primary lung cancer. -circulation_biomarker_diagnosis_ns hsa-mir-195 Osteosarcoma 25775010 "Our data suggest that altered levels of circulating miRNAs might have great potential to serve as novel, non-invasive biomarkers for osteosarcoma." -circulation_biomarker_diagnosis_ns hsa-mir-199a Osteosarcoma 25775010 "Our data suggest that altered levels of circulating miRNAs might have great potential to serve as novel, non-invasive biomarkers for osteosarcoma." -circulation_biomarker_diagnosis_ns hsa-mir-320a Osteosarcoma 25775010 "Our data suggest that altered levels of circulating miRNAs might have great potential to serve as novel, non-invasive biomarkers for osteosarcoma." -circulation_biomarker_diagnosis_ns hsa-mir-374a Osteosarcoma 25775010 "Our data suggest that altered levels of circulating miRNAs might have great potential to serve as novel, non-invasive biomarkers for osteosarcoma." -circulation_biomarker_diagnosis_ns hsa-mir-21 Neoplasms [unspecific] 25777797 "Finally, the protocol was applied to monitor miRNA-21 expression in epithelial to mesenchymal transition (EMT)-induced MCF-7 cells, an epithelial tumor cell line. CK expression was lost in these cells,whereas miRNA-21 was still expressed, suggesting that miRNA-21 might be a good marker for detecting CTCs with an EMT phenotype." -circulation_biomarker_diagnosis_ns hsa-mir-1 Myocardial Ischemic-Reperfusion Injury 25791720 "A time-dependent change in miR-1/208a/499 levels occurred during open-heart surgery, and these were associated with levels of cTnI and CK-MB.These results reveal that miRNAs may be sensitive biomarkers for I/R injury during open-heart surgery." -circulation_biomarker_diagnosis_ns hsa-mir-208a Myocardial Ischemic-Reperfusion Injury 25791720 "A time-dependent change in miR-1/208a/499 levels occurred during open-heart surgery, and these were associated with levels of cTnI and CK-MB.These results reveal that miRNAs may be sensitive biomarkers for I/R injury during open-heart surgery." -circulation_biomarker_diagnosis_ns hsa-mir-21 Myocardial Ischemic-Reperfusion Injury 25791720 "A time-dependent change in miR-1/208a/499 levels occurred during open-heart surgery, and these were associated with levels of cTnI and CK-MB.These results reveal that miRNAs may be sensitive biomarkers for I/R injury during open-heart surgery." -circulation_biomarker_diagnosis_ns hsa-mir-499 Myocardial Ischemic-Reperfusion Injury 25791720 "A time-dependent change in miR-1/208a/499 levels occurred during open-heart surgery, and these were associated with levels of cTnI and CK-MB.These results reveal that miRNAs may be sensitive biomarkers for I/R injury during open-heart surgery." -circulation_biomarker_diagnosis_ns hsa-mir-423 Colorectal Carcinoma 25807655 The significance of detection of serum miR-423-5p and miR-484 for diagnosis of colorectal cancer. -circulation_biomarker_diagnosis_ns hsa-mir-484 Colorectal Carcinoma 25807655 The significance of detection of serum miR-423-5p and miR-484 for diagnosis of colorectal cancer. -circulation_biomarker_diagnosis_ns hsa-mir-223 Sepsis 25810564 "Recent reports on alterations in miR-223 serum levels during sepsis revealed contradictory results, preventing a potential use of this miRNA in clinical routine. We clearly show that miR-223 serum levels do not reflect the presence of sepsis neither in mouse models nor in a large cohort of ICU patients and do not indicate clinical outcome of critically ill patients. Thus miR-223 serum levels should not be used as a biomarker in this setting." -circulation_biomarker_diagnosis_ns hsa-let-7a "Carcinoma, Hepatocellular, HBV-Related" 25814782 "These findings highlight the importance of validating reference genes before quantifying target miRNAs.Furthermore, our findings will improve studies that monitor hepatitis progression and will aid in the discovery of noninvasive biomarkers to diagnose early stage HCC." -circulation_biomarker_diagnosis_ns hsa-mir-125a Liver Diseases [unspecific] 25815788 "Serum microRNA-125a-5p, a useful biomarker in liver diseases, correlates with disease progression." -circulation_biomarker_diagnosis_ns hsa-mir-223 Pancreatic Neoplasms 25819175 "Plasma miR-223 might be a clinically useful biomarker for screening PCa, and predicting malignant potential of IPMN and the invasiveness of PCa." -circulation_biomarker_diagnosis_ns hsa-let-7d Epilepsy 25825351 "Circulating miRNAs were differentially regulated in epilepsy patients as compared with controls. MiR-106b-5p may serve as a novel, noninvasive biomarker to improve the current diagnosis of epilepsy." -circulation_biomarker_diagnosis_ns hsa-mir-106b Epilepsy 25825351 "Circulating miRNAs were differentially regulated in epilepsy patients as compared with controls. MiR-106b-5p may serve as a novel, noninvasive biomarker to improve the current diagnosis of epilepsy." -circulation_biomarker_diagnosis_ns hsa-mir-130a Epilepsy 25825351 "Circulating miRNAs were differentially regulated in epilepsy patients as compared with controls. MiR-106b-5p may serve as a novel, noninvasive biomarker to improve the current diagnosis of epilepsy." -circulation_biomarker_diagnosis_ns hsa-mir-146a Epilepsy 25825351 "Circulating miRNAs were differentially regulated in epilepsy patients as compared with controls. MiR-106b-5p may serve as a novel, noninvasive biomarker to improve the current diagnosis of epilepsy." -circulation_biomarker_diagnosis_ns hsa-mir-15a Epilepsy 25825351 "Circulating miRNAs were differentially regulated in epilepsy patients as compared with controls. MiR-106b-5p may serve as a novel, noninvasive biomarker to improve the current diagnosis of epilepsy." -circulation_biomarker_diagnosis_ns hsa-mir-194 Epilepsy 25825351 "Circulating miRNAs were differentially regulated in epilepsy patients as compared with controls. MiR-106b-5p may serve as a novel, noninvasive biomarker to improve the current diagnosis of epilepsy." -circulation_biomarker_diagnosis_ns hsa-mir-155 "Cardiomyopathy, Dilated" 25840506 We identified specific miRNAs that are differentially regulated between children with DCM who need a transplant compared with children with DCM who recover. A unique biomarker signature of miRNAs that are specific to children with DCM who have the potential to recover would be valuable in risk stratification of this challenging patient population. -circulation_biomarker_diagnosis_ns hsa-mir-636 "Cardiomyopathy, Dilated" 25840506 We identified specific miRNAs that are differentially regulated between children with DCM who need a transplant compared with children with DCM who recover. A unique biomarker signature of miRNAs that are specific to children with DCM who have the potential to recover would be valuable in risk stratification of this challenging patient population. -circulation_biomarker_diagnosis_ns hsa-mir-639 "Cardiomyopathy, Dilated" 25840506 We identified specific miRNAs that are differentially regulated between children with DCM who need a transplant compared with children with DCM who recover. A unique biomarker signature of miRNAs that are specific to children with DCM who have the potential to recover would be valuable in risk stratification of this challenging patient population. -circulation_biomarker_diagnosis_ns hsa-mir-646 "Cardiomyopathy, Dilated" 25840506 We identified specific miRNAs that are differentially regulated between children with DCM who need a transplant compared with children with DCM who recover. A unique biomarker signature of miRNAs that are specific to children with DCM who have the potential to recover would be valuable in risk stratification of this challenging patient population. -circulation_biomarker_diagnosis_ns hsa-let-7 Neoplasms [unspecific] 25856466 "Let-7, mir-98 and mir-183 as biomarkers for cancer and schizophrenia [corrected]." -circulation_biomarker_diagnosis_ns hsa-mir-125b "Squamous Cell Carcinoma, Oral" 25858373 "Due to the satisfactory diagnostic performance, plasma miR-125b can be used as a promising biomarker in OSCC." -circulation_biomarker_diagnosis_ns hsa-let-7a "Carcinoma, Gallbladder" 25861754 "Our results suggest a possible pathological relationship between the differential expression of miRNA in peripheral blood and GBC, and these dysregulated miRNAs could be novel tumor biomarkers for early detection of GBC." -circulation_biomarker_diagnosis_ns hsa-mir-143 "Carcinoma, Gallbladder" 25861754 "Our results suggest a possible pathological relationship between the differential expression of miRNA in peripheral blood and GBC, and these dysregulated miRNAs could be novel tumor biomarkers for early detection of GBC." -circulation_biomarker_diagnosis_ns hsa-mir-187 "Carcinoma, Gallbladder" 25861754 "Our results suggest a possible pathological relationship between the differential expression of miRNA in peripheral blood and GBC, and these dysregulated miRNAs could be novel tumor biomarkers for early detection of GBC." -circulation_biomarker_diagnosis_ns hsa-mir-202 "Carcinoma, Gallbladder" 25861754 "Our results suggest a possible pathological relationship between the differential expression of miRNA in peripheral blood and GBC, and these dysregulated miRNAs could be novel tumor biomarkers for early detection of GBC." -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Gallbladder" 25861754 "Our results suggest a possible pathological relationship between the differential expression of miRNA in peripheral blood and GBC, and these dysregulated miRNAs could be novel tumor biomarkers for early detection of GBC." -circulation_biomarker_diagnosis_ns hsa-mir-335 "Carcinoma, Gallbladder" 25861754 "Our results suggest a possible pathological relationship between the differential expression of miRNA in peripheral blood and GBC, and these dysregulated miRNAs could be novel tumor biomarkers for early detection of GBC." -circulation_biomarker_diagnosis_ns hsa-mir-146a Chronic Hepatitis C 25877355 Involvement of TLR2-MyD88 in abnormal expression of miR-146a in peripheral blood monocytes of patients with chronic hepatitis C. -circulation_biomarker_diagnosis_ns hsa-mir-10b Huntington Disease 25889241 "These results demonstrate that miRNA expression in cortical BA9 provides insight into striatal involvement and support a role for these miRNAs,particularly miR-10b-5p, in HD pathogenicity. The miRNAs identified in our studies of postmortem brain tissue may be detectable in peripheral fluids and thus warrant consideration as accessible biomarkers for disease stage, rate of progression, and other important clinical characteristics of HD." -circulation_biomarker_diagnosis_ns hsa-mir-106b "Carcinoma, Hepatocellular" 25894380 We found that plasma miR-106b has clinical value in the detection of HCC from healthy people and CLD patients. Further large-scale study may be needed to validate our findings. -circulation_biomarker_diagnosis_ns hsa-mir-34b "Carcinoma, Colon" 25894979 Increased microRNA-34b and -34c predominantly expressed in stromal tissues is associated with poor prognosis in human colon cancer. -circulation_biomarker_diagnosis_ns hsa-mir-34c "Carcinoma, Colon" 25894979 Increased microRNA-34b and -34c predominantly expressed in stromal tissues is associated with poor prognosis in human colon cancer. -circulation_biomarker_diagnosis_ns hsa-mir-1275 Intrahepatic Cholangiocarcinoma 25903557 "The association of unique miRNA profiles with different ICC subtypes suggests the involvement of specific miRNAs during ICC tumor progression. In plasma, an eight-miRNA signature associated with ICC could form the foundation of an accessible (plasma-based) miRNA-based biomarker for the early detection of ICC." -circulation_biomarker_diagnosis_ns hsa-mir-193a Intrahepatic Cholangiocarcinoma 25903557 "The association of unique miRNA profiles with different ICC subtypes suggests the involvement of specific miRNAs during ICC tumor progression. In plasma, an eight-miRNA signature associated with ICC could form the foundation of an accessible (plasma-based) miRNA-based biomarker for the early detection of ICC." -circulation_biomarker_diagnosis_ns hsa-mir-199b Intrahepatic Cholangiocarcinoma 25903557 "The association of unique miRNA profiles with different ICC subtypes suggests the involvement of specific miRNAs during ICC tumor progression. In plasma, an eight-miRNA signature associated with ICC could form the foundation of an accessible (plasma-based) miRNA-based biomarker for the early detection of ICC." -circulation_biomarker_diagnosis_ns hsa-mir-320a Intrahepatic Cholangiocarcinoma 25903557 "The association of unique miRNA profiles with different ICC subtypes suggests the involvement of specific miRNAs during ICC tumor progression. In plasma, an eight-miRNA signature associated with ICC could form the foundation of an accessible (plasma-based) miRNA-based biomarker for the early detection of ICC." -circulation_biomarker_diagnosis_ns hsa-mir-483 Intrahepatic Cholangiocarcinoma 25903557 "The association of unique miRNA profiles with different ICC subtypes suggests the involvement of specific miRNAs during ICC tumor progression. In plasma, an eight-miRNA signature associated with ICC could form the foundation of an accessible (plasma-based) miRNA-based biomarker for the early detection of ICC." -circulation_biomarker_diagnosis_ns hsa-mir-505 Intrahepatic Cholangiocarcinoma 25903557 "The association of unique miRNA profiles with different ICC subtypes suggests the involvement of specific miRNAs during ICC tumor progression. In plasma, an eight-miRNA signature associated with ICC could form the foundation of an accessible (plasma-based) miRNA-based biomarker for the early detection of ICC." -circulation_biomarker_diagnosis_ns hsa-mir-874 Intrahepatic Cholangiocarcinoma 25903557 "The association of unique miRNA profiles with different ICC subtypes suggests the involvement of specific miRNAs during ICC tumor progression. In plasma, an eight-miRNA signature associated with ICC could form the foundation of an accessible (plasma-based) miRNA-based biomarker for the early detection of ICC." -circulation_biomarker_diagnosis_ns hsa-mir-148 "Carcinoma, Lung, Non-Small-Cell" 25904302 The results of present study suggest that the expression levels of circulating miR-148/152 family may serve as biomarkers for NSCLC. -circulation_biomarker_diagnosis_ns hsa-mir-152 "Carcinoma, Lung, Non-Small-Cell" 25904302 The results of present study suggest that the expression levels of circulating miR-148/152 family may serve as biomarkers for NSCLC. -circulation_biomarker_diagnosis_ns hsa-mir-21 Neoplasms [unspecific] 25907045 "we selectively detected cancer cell-derived exosomal miRNA-21 among heterogeneous exosome mixtures and in human serum. The method developed in the article is simple, fast, and sensitive, so it will offer great opportunities for the high-throughput diagnosis and prognosis of diseases." -circulation_biomarker_diagnosis_ns hsa-mir-221 "Carcinoma, Renal Cell" 25909813 Combined Influence of EGF+61G>A and TGFB+869T>C Functional Polymorphisms in Renal Cell Carcinoma Progression and Overall Survival: The Link to Plasma Circulating MiR-7 and MiR-221/222 Expression. -circulation_biomarker_diagnosis_ns hsa-mir-222 "Carcinoma, Renal Cell" 25909813 Combined Influence of EGF+61G>A and TGFB+869T>C Functional Polymorphisms in Renal Cell Carcinoma Progression and Overall Survival: The Link to Plasma Circulating MiR-7 and MiR-221/222 Expression. -circulation_biomarker_diagnosis_ns hsa-mir-7 "Carcinoma, Renal Cell" 25909813 Combined Influence of EGF+61G>A and TGFB+869T>C Functional Polymorphisms in Renal Cell Carcinoma Progression and Overall Survival: The Link to Plasma Circulating MiR-7 and MiR-221/222 Expression. -circulation_biomarker_diagnosis_ns hsa-let-7a "Squamous Cell Carcinoma, Esophageal" 25914476 Plasma miR-20a and let-7a levels are significantly altered in patients with ESCC and can be used as potential biomarkers in the diagnosis of ESCC. -circulation_biomarker_diagnosis_ns hsa-mir-20a "Squamous Cell Carcinoma, Esophageal" 25914476 Plasma miR-20a and let-7a levels are significantly altered in patients with ESCC and can be used as potential biomarkers in the diagnosis of ESCC. -circulation_biomarker_diagnosis_ns hsa-mir-122 Acute Coronary Syndrome 25933289 "Plasma miR-122, -140-3p, -720, -2861, and -3149 were associated with and potentially novel biomarkers for ACS." -circulation_biomarker_diagnosis_ns hsa-mir-3149 Acute Coronary Syndrome 25933289 "Plasma miR-122, -140-3p, -720, -2861, and -3149 were associated with and potentially novel biomarkers for ACS." -circulation_biomarker_diagnosis_ns hsa-mir-572 Multiple Sclerosis 25947625 Evaluation of miR-572 may serve as a non-invasive biomarker for remyelination. -circulation_biomarker_diagnosis_ns hsa-mir-126 Brain Disease [unspecific] 25947950 MiRNAs are detectable in cerebral microdialysate; a large group of miRNAs consistently showed a high RR in cerebral microdialysate. Measurement of cerebral interstitial miRNA concentrations may aid in the investigation of secondary brain injury in neurocritical conditions. -circulation_biomarker_diagnosis_ns hsa-mir-142 Brain Disease [unspecific] 25947950 MiRNAs are detectable in cerebral microdialysate; a large group of miRNAs consistently showed a high RR in cerebral microdialysate. Measurement of cerebral interstitial miRNA concentrations may aid in the investigation of secondary brain injury in neurocritical conditions. -circulation_biomarker_diagnosis_ns hsa-mir-146b Brain Disease [unspecific] 25947950 MiRNAs are detectable in cerebral microdialysate; a large group of miRNAs consistently showed a high RR in cerebral microdialysate. Measurement of cerebral interstitial miRNA concentrations may aid in the investigation of secondary brain injury in neurocritical conditions. -circulation_biomarker_diagnosis_ns hsa-mir-150 Brain Disease [unspecific] 25947950 MiRNAs are detectable in cerebral microdialysate; a large group of miRNAs consistently showed a high RR in cerebral microdialysate. Measurement of cerebral interstitial miRNA concentrations may aid in the investigation of secondary brain injury in neurocritical conditions. -circulation_biomarker_diagnosis_ns hsa-mir-155 Brain Disease [unspecific] 25947950 MiRNAs are detectable in cerebral microdialysate; a large group of miRNAs consistently showed a high RR in cerebral microdialysate. Measurement of cerebral interstitial miRNA concentrations may aid in the investigation of secondary brain injury in neurocritical conditions. -circulation_biomarker_diagnosis_ns hsa-mir-15b Brain Disease [unspecific] 25947950 MiRNAs are detectable in cerebral microdialysate; a large group of miRNAs consistently showed a high RR in cerebral microdialysate. Measurement of cerebral interstitial miRNA concentrations may aid in the investigation of secondary brain injury in neurocritical conditions. -circulation_biomarker_diagnosis_ns hsa-mir-191 Brain Disease [unspecific] 25947950 MiRNAs are detectable in cerebral microdialysate; a large group of miRNAs consistently showed a high RR in cerebral microdialysate. Measurement of cerebral interstitial miRNA concentrations may aid in the investigation of secondary brain injury in neurocritical conditions. -circulation_biomarker_diagnosis_ns hsa-mir-193a Brain Disease [unspecific] 25947950 MiRNAs are detectable in cerebral microdialysate; a large group of miRNAs consistently showed a high RR in cerebral microdialysate. Measurement of cerebral interstitial miRNA concentrations may aid in the investigation of secondary brain injury in neurocritical conditions. -circulation_biomarker_diagnosis_ns hsa-mir-29b Brain Disease [unspecific] 25947950 MiRNAs are detectable in cerebral microdialysate; a large group of miRNAs consistently showed a high RR in cerebral microdialysate. Measurement of cerebral interstitial miRNA concentrations may aid in the investigation of secondary brain injury in neurocritical conditions. -circulation_biomarker_diagnosis_ns hsa-mir-30c Brain Disease [unspecific] 25947950 MiRNAs are detectable in cerebral microdialysate; a large group of miRNAs consistently showed a high RR in cerebral microdialysate. Measurement of cerebral interstitial miRNA concentrations may aid in the investigation of secondary brain injury in neurocritical conditions. -circulation_biomarker_diagnosis_ns hsa-mir-32 Brain Disease [unspecific] 25947950 MiRNAs are detectable in cerebral microdialysate; a large group of miRNAs consistently showed a high RR in cerebral microdialysate. Measurement of cerebral interstitial miRNA concentrations may aid in the investigation of secondary brain injury in neurocritical conditions. -circulation_biomarker_diagnosis_ns hsa-mir-34a Brain Disease [unspecific] 25947950 MiRNAs are detectable in cerebral microdialysate; a large group of miRNAs consistently showed a high RR in cerebral microdialysate. Measurement of cerebral interstitial miRNA concentrations may aid in the investigation of secondary brain injury in neurocritical conditions. -circulation_biomarker_diagnosis_ns hsa-mir-744 Brain Disease [unspecific] 25947950 MiRNAs are detectable in cerebral microdialysate; a large group of miRNAs consistently showed a high RR in cerebral microdialysate. Measurement of cerebral interstitial miRNA concentrations may aid in the investigation of secondary brain injury in neurocritical conditions. -circulation_biomarker_diagnosis_ns hsa-mir-886 Brain Disease [unspecific] 25947950 MiRNAs are detectable in cerebral microdialysate; a large group of miRNAs consistently showed a high RR in cerebral microdialysate. Measurement of cerebral interstitial miRNA concentrations may aid in the investigation of secondary brain injury in neurocritical conditions. -circulation_biomarker_diagnosis_ns hsa-mir-146a Uveal Melanoma 25951497 "Our findings suggest the possibility to detect in VH and serum of UM patients diagnostic miRNAs released by the affected eye: based on this,miR-146a could be considered a potential circulating marker of UM." -circulation_biomarker_diagnosis_ns hsa-mir-21 Uveal Melanoma 25951497 "Our findings suggest the possibility to detect in VH and serum of UM patients diagnostic miRNAs released by the affected eye: based on this,miR-146a could be considered a potential circulating marker of UM." -circulation_biomarker_diagnosis_ns hsa-mir-34a Uveal Melanoma 25951497 "Our findings suggest the possibility to detect in VH and serum of UM patients diagnostic miRNAs released by the affected eye: based on this,miR-146a could be considered a potential circulating marker of UM." -circulation_biomarker_diagnosis_ns hsa-mir-130b Diabetic Nephropathy 25952368 "Our findings suggest that serum miR-130b may be a new biomarker for the early diagnosis of DN in T2DM. Circulating miR-130b may possibly be involved in the pathological mechanism of DN, such as lipid metabolic disorders, oxidative stress, extracellular matrix deposition and renal fibrosis." -circulation_biomarker_diagnosis_ns hsa-mir-27a Osteosarcoma 25960240 miR-27a expression may be elevated in sera of osteosarcoma patients and in turn contributes to aggressive progression of this malignancy. Detection of serum miR-27a levels may have clinical potentials as a non-invasive diagnostic/prognostic biomarker for osteosarcoma patients. -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Hepatocellular" 25973032 Significance of serum microRNA-21 in diagnosis of hepatocellular carcinoma (HCC):clinical analyses of patients and an HCC rat model. -circulation_biomarker_diagnosis_ns hsa-mir-194 Myelodysplastic Syndromes 25975751 MicroRNA-194-5p could serve as a diagnostic and prognostic biomarker in myelodysplastic syndromes. -circulation_biomarker_diagnosis_ns hsa-mir-181b Hepatitis B Virus Infection 25976622 Serum miR-181b is correlated with liver and serum HBV DNA levels as well as disease progression in CHB. -circulation_biomarker_diagnosis_ns hsa-mir-155 Preeclampsia 25981845 "The systemic effect of PE on maternal systems is evident in the circulating miRNAome with substantial alterations in miRNA expression in women who develop severe PE. In addition we provide novel evidence of disruption to miR-221 expression 1 year postpartum following a pregnancy complicated by PE compared to normotensive time-matched controls, which may allude to persistent inflammation in these women after delivery." -circulation_biomarker_diagnosis_ns hsa-mir-210 Preeclampsia 25981845 "The systemic effect of PE on maternal systems is evident in the circulating miRNAome with substantial alterations in miRNA expression in women who develop severe PE. In addition we provide novel evidence of disruption to miR-221 expression 1 year postpartum following a pregnancy complicated by PE compared to normotensive time-matched controls, which may allude to persistent inflammation in these women after delivery." -circulation_biomarker_diagnosis_ns hsa-mir-222 Preeclampsia 25981845 "The systemic effect of PE on maternal systems is evident in the circulating miRNAome with substantial alterations in miRNA expression in women who develop severe PE. In addition we provide novel evidence of disruption to miR-221 expression 1 year postpartum following a pregnancy complicated by PE compared to normotensive time-matched controls, which may allude to persistent inflammation in these women after delivery." -circulation_biomarker_diagnosis_ns hsa-mir-296 Preeclampsia 25981845 "The systemic effect of PE on maternal systems is evident in the circulating miRNAome with substantial alterations in miRNA expression in women who develop severe PE. In addition we provide novel evidence of disruption to miR-221 expression 1 year postpartum following a pregnancy complicated by PE compared to normotensive time-matched controls, which may allude to persistent inflammation in these women after delivery." -circulation_biomarker_diagnosis_ns hsa-mir-29b Preeclampsia 25981845 "The systemic effect of PE on maternal systems is evident in the circulating miRNAome with substantial alterations in miRNA expression in women who develop severe PE. In addition we provide novel evidence of disruption to miR-221 expression 1 year postpartum following a pregnancy complicated by PE compared to normotensive time-matched controls, which may allude to persistent inflammation in these women after delivery." -circulation_biomarker_diagnosis_ns hsa-mir-98 Preeclampsia 25981845 "The systemic effect of PE on maternal systems is evident in the circulating miRNAome with substantial alterations in miRNA expression in women who develop severe PE. In addition we provide novel evidence of disruption to miR-221 expression 1 year postpartum following a pregnancy complicated by PE compared to normotensive time-matched controls, which may allude to persistent inflammation in these women after delivery." -circulation_biomarker_diagnosis_ns hsa-mir-520h Breast Neoplasms 25982274 miR-520h is crucial for DAPK2 regulation and breast cancer progression. -circulation_biomarker_diagnosis_ns hsa-mir-19 Crohn Disease 25985247 These data identify miR-19-3p as a potential circulating marker of stricturing CD. Our data show that microRNAs have utility as noninvasive biomarkers of stricturing CD. Further longitudinal studies are required to determine the prognostic value of miR-19-3p at diagnosis. -circulation_biomarker_diagnosis_ns hsa-mir-182 Heart Failure 25985726 "miR-182 (p = 0.04), miR-200a* (p = 0.019), and miR-568 (p = 0.023) were found to be inversely correlated with LVM index (LVMI), while miR-155 (p = 0.019) and miR-595 (p = 0.04) were determined to be positively correlated with LVMI." -circulation_biomarker_diagnosis_ns hsa-mir-132 Schizophrenia 25985888 Alterations of miR-132 are novel diagnostic biomarkers in peripheral blood of schizophrenia patients. -circulation_biomarker_diagnosis_ns hsa-mir-18b Rectal Neoplasms 25990502 MicroRNA expression in patient plasma changes during preoperative CRT. The alteration is not continuous and the meaning requires additional analysis on a larger patient cohort. The co-occurrence of reduced miR-18b and miR-20a expression with lymph node negativity after preoperative CRT could help to stratify the surgical procedure with respect to total mesorectal excision and LR if validated prospectively. -circulation_biomarker_diagnosis_ns hsa-mir-20a Rectal Neoplasms 25990502 MicroRNA expression in patient plasma changes during preoperative CRT. The alteration is not continuous and the meaning requires additional analysis on a larger patient cohort. The co-occurrence of reduced miR-18b and miR-20a expression with lymph node negativity after preoperative CRT could help to stratify the surgical procedure with respect to total mesorectal excision and LR if validated prospectively. -circulation_biomarker_diagnosis_ns hsa-mir-30d Heart Failure 25995320 Baseline plasma miR-30d level is associated with response to CRT in HFDYS in this translational pilot study. MiR-30d increase in cardiomyocytes correlates with areas of increased wall stress in HFDYS and is protective against deleterious tumor necrosis factor signaling. -circulation_biomarker_diagnosis_ns hsa-mir-183 Human Immunodeficiency Virus Infection 25997625 "We show for the first time a joint miRNA and mRNA expression profile related to a HIV-1 latency phenotype, outline a dynamic network of potential regulators involving in HIV-1 latency or replication state, and gain new insights into the source messages for affecting HIV-1 latency." -circulation_biomarker_diagnosis_ns hsa-mir-125 Polycythemia Vera 26011312 "In conclusion, our data indicate that other factors such as aberrant miR-125 expression may influence on the disease phenotype in patients with PV and ET." -circulation_biomarker_diagnosis_ns hsa-mir-497 Bladder Neoplasms 26014226 Circulating miR-497 and miR-663b in plasma are potential novel biomarkers for bladder cancer. -circulation_biomarker_diagnosis_ns hsa-mir-663a Bladder Neoplasms 26014226 Circulating miR-497 and miR-663b in plasma are potential novel biomarkers for bladder cancer. -circulation_biomarker_diagnosis_ns hsa-mir-142 Vasculitis 26016752 "In this first study ever on circulating miRNA profiles in AAV, we find clear indication of their potential as biomarkers for diagnosis and classification, but more studies are needed to identify the best markers as well as the mechanisms responsible for variations." -circulation_biomarker_diagnosis_ns hsa-mir-20a Vasculitis 26016752 "In this first study ever on circulating miRNA profiles in AAV, we find clear indication of their potential as biomarkers for diagnosis and classification, but more studies are needed to identify the best markers as well as the mechanisms responsible for variations." -circulation_biomarker_diagnosis_ns hsa-mir-221 Vasculitis 26016752 "In this first study ever on circulating miRNA profiles in AAV, we find clear indication of their potential as biomarkers for diagnosis and classification, but more studies are needed to identify the best markers as well as the mechanisms responsible for variations." -circulation_biomarker_diagnosis_ns hsa-mir-29a Vasculitis 26016752 "In this first study ever on circulating miRNA profiles in AAV, we find clear indication of their potential as biomarkers for diagnosis and classification, but more studies are needed to identify the best markers as well as the mechanisms responsible for variations." -circulation_biomarker_diagnosis_ns hsa-mir-34a Vasculitis 26016752 "In this first study ever on circulating miRNA profiles in AAV, we find clear indication of their potential as biomarkers for diagnosis and classification, but more studies are needed to identify the best markers as well as the mechanisms responsible for variations." -circulation_biomarker_diagnosis_ns hsa-mir-383 Vasculitis 26016752 "In this first study ever on circulating miRNA profiles in AAV, we find clear indication of their potential as biomarkers for diagnosis and classification, but more studies are needed to identify the best markers as well as the mechanisms responsible for variations." -circulation_biomarker_diagnosis_ns hsa-mir-92a Vasculitis 26016752 "In this first study ever on circulating miRNA profiles in AAV, we find clear indication of their potential as biomarkers for diagnosis and classification, but more studies are needed to identify the best markers as well as the mechanisms responsible for variations." -circulation_biomarker_diagnosis_ns hsa-mir-24 "Carcinoma, Nasopharyngeal" 26018275 Plasma miR-24 may serve as a novel molecular biomarker for early diagnosis and prognosis of NPC. -circulation_biomarker_diagnosis_ns hsa-let-7g Osteoporosis 26026730 "In total 6 miRNAs, miR-10a-5p, miR-10b-5p, miR-133b, miR-22-3p, miR-328-3p, and let-7g-5p exhibited significantly different serum levels in response to fracture" -circulation_biomarker_diagnosis_ns hsa-mir-107 Breast Neoplasms 26033453 "Aberrant plasma levels of circulating miR-16, miR-107, miR-130a and miR-146a are associated with lymph node metastasis and receptor status of breast cancer patients." -circulation_biomarker_diagnosis_ns hsa-mir-130a Breast Neoplasms 26033453 "Aberrant plasma levels of circulating miR-16, miR-107, miR-130a and miR-146a are associated with lymph node metastasis and receptor status of breast cancer patients." -circulation_biomarker_diagnosis_ns hsa-mir-146a Breast Neoplasms 26033453 "Aberrant plasma levels of circulating miR-16, miR-107, miR-130a and miR-146a are associated with lymph node metastasis and receptor status of breast cancer patients." -circulation_biomarker_diagnosis_ns hsa-mir-16 Breast Neoplasms 26033453 "Aberrant plasma levels of circulating miR-16, miR-107, miR-130a and miR-146a are associated with lymph node metastasis and receptor status of breast cancer patients." -circulation_biomarker_diagnosis_ns hsa-mir-200c Neoplasms [unspecific] 26035744 "in clinicopathology analysis,miR-200c expression in blood was significantly associated with TNM stage, lymph node metastasis and distant metastasis. MiR-200c may have the potential to become a new blood biomarker to monitor cancer prognosis and progression." -circulation_biomarker_diagnosis_ns hsa-mir-125b Colorectal Carcinoma 26038573 "Because serum levels of miR-21, miR-29a, and miR-125b discriminated patients with early colorectal neoplasm from healthy controls, our data highlight the potential clinical use of these molecular signatures for noninvasive screening of patients with colorectal neoplasia." -circulation_biomarker_diagnosis_ns hsa-mir-21 Colorectal Carcinoma 26038573 "Because serum levels of miR-21, miR-29a, and miR-125b discriminated patients with early colorectal neoplasm from healthy controls, our data highlight the potential clinical use of these molecular signatures for noninvasive screening of patients with colorectal neoplasia." -circulation_biomarker_diagnosis_ns hsa-mir-29a Colorectal Carcinoma 26038573 "Because serum levels of miR-21, miR-29a, and miR-125b discriminated patients with early colorectal neoplasm from healthy controls, our data highlight the potential clinical use of these molecular signatures for noninvasive screening of patients with colorectal neoplasia." -circulation_biomarker_diagnosis_ns hsa-mir-1246 Melanoma 26039581 A profile of 2 miRNAs (miR-1246 and miR-185) significantly associated with metastatic melanoma with a sensitivity of 90.5% and a specificity of 89.1% was identified. This plasma miRNA profile may become an accurate non-invasive biomarker for melanoma. -circulation_biomarker_diagnosis_ns hsa-mir-185 Melanoma 26039581 A profile of 2 miRNAs (miR-1246 and miR-185) significantly associated with metastatic melanoma with a sensitivity of 90.5% and a specificity of 89.1% was identified. This plasma miRNA profile may become an accurate non-invasive biomarker for melanoma. -circulation_biomarker_diagnosis_ns hsa-mir-206 Melanoma 26045823 "Our results offer the convincing evidence that miR-206 may be implicated in aggressive progression of melanoma. More importantly, the serum level of miR-206 may be a noninvasive prognostic biomarker for the patients with melanoma." -circulation_biomarker_diagnosis_ns hsa-mir-586 Graft-Versus-Host Disease 26051902 Plasma microRNA-586 is a new biomarker for acute graft-versus-host disease. -circulation_biomarker_diagnosis_ns hsa-mir-101 Mycobacterium tuberculosis Infection 26053546 A unique signature of 11 microRNAs in human macrophages was identified to differentiate active MTB disease from LTBI and healthy controls. -circulation_biomarker_diagnosis_ns hsa-mir-140 Mycobacterium tuberculosis Infection 26053546 A unique signature of 11 microRNAs in human macrophages was identified to differentiate active MTB disease from LTBI and healthy controls. -circulation_biomarker_diagnosis_ns hsa-mir-146b Mycobacterium tuberculosis Infection 26053546 A unique signature of 11 microRNAs in human macrophages was identified to differentiate active MTB disease from LTBI and healthy controls. -circulation_biomarker_diagnosis_ns hsa-mir-150 Mycobacterium tuberculosis Infection 26053546 A unique signature of 11 microRNAs in human macrophages was identified to differentiate active MTB disease from LTBI and healthy controls. -circulation_biomarker_diagnosis_ns hsa-mir-193a Mycobacterium tuberculosis Infection 26053546 A unique signature of 11 microRNAs in human macrophages was identified to differentiate active MTB disease from LTBI and healthy controls. -circulation_biomarker_diagnosis_ns hsa-mir-21 Mycobacterium tuberculosis Infection 26053546 A unique signature of 11 microRNAs in human macrophages was identified to differentiate active MTB disease from LTBI and healthy controls. -circulation_biomarker_diagnosis_ns hsa-mir-296 Mycobacterium tuberculosis Infection 26053546 A unique signature of 11 microRNAs in human macrophages was identified to differentiate active MTB disease from LTBI and healthy controls. -circulation_biomarker_diagnosis_ns hsa-mir-485 Mycobacterium tuberculosis Infection 26053546 A unique signature of 11 microRNAs in human macrophages was identified to differentiate active MTB disease from LTBI and healthy controls. -circulation_biomarker_diagnosis_ns hsa-mir-125b Breast Neoplasms 26056355 Circulating miRNAs reflect the presence of breast tumors. The identification of deregulated miRNAs in plasma of patients with breast cancer supports the use of circulating miRNAs as a method for early breast cancer detection. -circulation_biomarker_diagnosis_ns hsa-mir-21 Breast Neoplasms 26056355 Circulating miRNAs reflect the presence of breast tumors. The identification of deregulated miRNAs in plasma of patients with breast cancer supports the use of circulating miRNAs as a method for early breast cancer detection. -circulation_biomarker_diagnosis_ns hsa-mir-505 Breast Neoplasms 26056355 Circulating miRNAs reflect the presence of breast tumors. The identification of deregulated miRNAs in plasma of patients with breast cancer supports the use of circulating miRNAs as a method for early breast cancer detection. -circulation_biomarker_diagnosis_ns hsa-mir-96 Breast Neoplasms 26056355 Circulating miRNAs reflect the presence of breast tumors. The identification of deregulated miRNAs in plasma of patients with breast cancer supports the use of circulating miRNAs as a method for early breast cancer detection. -circulation_biomarker_diagnosis_ns hsa-mir-185 Gastric Neoplasms 26059512 "In conclusion, we identified a five-miRNA signature in the peripheral plasma which could serve as a non-invasive biomarker in detection of GC." -circulation_biomarker_diagnosis_ns hsa-mir-20a Gastric Neoplasms 26059512 "In conclusion, we identified a five-miRNA signature in the peripheral plasma which could serve as a non-invasive biomarker in detection of GC." -circulation_biomarker_diagnosis_ns hsa-mir-210 Gastric Neoplasms 26059512 "In conclusion, we identified a five-miRNA signature in the peripheral plasma which could serve as a non-invasive biomarker in detection of GC." -circulation_biomarker_diagnosis_ns hsa-mir-92b Gastric Neoplasms 26059512 "In conclusion, we identified a five-miRNA signature in the peripheral plasma which could serve as a non-invasive biomarker in detection of GC." -circulation_biomarker_diagnosis_ns hsa-mir-103a Autism Spectrum Disorder 26061495 "this study provides the first global miRNA expression profile of ASD in China. The differentially expressed miR-34b may potentially explain the higher percentage of male ASD patients, and the aberrantly expressed miR-103a-3p may contribute to the abnormal ubiquitin-mediated proteolysis observed in ASD." -circulation_biomarker_diagnosis_ns hsa-mir-34b Autism Spectrum Disorder 26061495 "this study provides the first global miRNA expression profile of ASD in China. The differentially expressed miR-34b may potentially explain the higher percentage of male ASD patients, and the aberrantly expressed miR-103a-3p may contribute to the abnormal ubiquitin-mediated proteolysis observed in ASD." -circulation_biomarker_diagnosis_ns hsa-mir-21 Breast Neoplasms 26063582 "In conclusion, our findings demonstrate that serum miR-21 expression profile may serve as a potential non-invasive diagnostic and prognostic biomarker for breast cancer." -circulation_biomarker_diagnosis_ns hsa-mir-1246 "Leukemia, Myeloid, Acute" 26067326 "We propose development of serum exosome miRNA as a platform for a novel,sensitive compartment biomarker for prospective tracking and early detection of AML recurrence." -circulation_biomarker_diagnosis_ns hsa-mir-155 "Leukemia, Myeloid, Acute" 26067326 "We propose development of serum exosome miRNA as a platform for a novel,sensitive compartment biomarker for prospective tracking and early detection of AML recurrence." -circulation_biomarker_diagnosis_ns hsa-mir-199a Osteosarcoma 26069101 Identification of miR-199a-5p in serum as noninvasive biomarkers for detecting and monitoring osteosarcoma. -circulation_biomarker_diagnosis_ns hsa-mir-3662 Lung Neoplasms 26079400 Plasma circulating microRNA-944 and microRNA-3662 as potential histologic type-specific early lung cancer biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-944 Lung Neoplasms 26079400 Plasma circulating microRNA-944 and microRNA-3662 as potential histologic type-specific early lung cancer biomarkers. -circulation_biomarker_diagnosis_ns hsa-let-7a Liver Neoplasms 26082194 Assessment of endogenous reference gene suitability for serum exosomal microRNA expression analysis in liver carcinoma resection studies. -circulation_biomarker_diagnosis_ns hsa-mir-103 Liver Neoplasms 26082194 Assessment of endogenous reference gene suitability for serum exosomal microRNA expression analysis in liver carcinoma resection studies. -circulation_biomarker_diagnosis_ns hsa-mir-16 Liver Neoplasms 26082194 Assessment of endogenous reference gene suitability for serum exosomal microRNA expression analysis in liver carcinoma resection studies. -circulation_biomarker_diagnosis_ns hsa-mir-191 Liver Neoplasms 26082194 Assessment of endogenous reference gene suitability for serum exosomal microRNA expression analysis in liver carcinoma resection studies. -circulation_biomarker_diagnosis_ns hsa-mir-221 Liver Neoplasms 26082194 Assessment of endogenous reference gene suitability for serum exosomal microRNA expression analysis in liver carcinoma resection studies. -circulation_biomarker_diagnosis_ns hsa-mir-26a Liver Neoplasms 26082194 Assessment of endogenous reference gene suitability for serum exosomal microRNA expression analysis in liver carcinoma resection studies. -circulation_biomarker_diagnosis_ns hsa-mir-451 Liver Neoplasms 26082194 Assessment of endogenous reference gene suitability for serum exosomal microRNA expression analysis in liver carcinoma resection studies. -circulation_biomarker_diagnosis_ns hsa-mir-34c "Diabetes Mellitus, Type 2" 26083362 "The expression profile of microRNAs/mRNAs in monocytes of T2D patients indicates an altered adhesion, differentiation, and shape change potential. Monocyte inflammatory activation was only found in patients with normal serum lipids. Abnormal lipid values coincided with a reduced monocyte inflammatory state." -circulation_biomarker_diagnosis_ns hsa-mir-133a "Cardiomyopathy, Hypertrophic" 26086795 "We demonstrated that miR-29a and miR-29c show a specific signature to distinguish between aortic stenosis, hypertrophic non-obstructive and obstructive cardiomyopathies and thus could be developed into clinically useful biomarkers." -circulation_biomarker_diagnosis_ns hsa-mir-143 "Cardiomyopathy, Hypertrophic" 26086795 "We demonstrated that miR-29a and miR-29c show a specific signature to distinguish between aortic stenosis, hypertrophic non-obstructive and obstructive cardiomyopathies and thus could be developed into clinically useful biomarkers." -circulation_biomarker_diagnosis_ns hsa-mir-145 "Cardiomyopathy, Hypertrophic" 26086795 "We demonstrated that miR-29a and miR-29c show a specific signature to distinguish between aortic stenosis, hypertrophic non-obstructive and obstructive cardiomyopathies and thus could be developed into clinically useful biomarkers." -circulation_biomarker_diagnosis_ns hsa-mir-192 "Cardiomyopathy, Hypertrophic" 26086795 "We demonstrated that miR-29a and miR-29c show a specific signature to distinguish between aortic stenosis, hypertrophic non-obstructive and obstructive cardiomyopathies and thus could be developed into clinically useful biomarkers." -circulation_biomarker_diagnosis_ns hsa-mir-29a "Cardiomyopathy, Hypertrophic" 26086795 "We demonstrated that miR-29a and miR-29c show a specific signature to distinguish between aortic stenosis, hypertrophic non-obstructive and obstructive cardiomyopathies and thus could be developed into clinically useful biomarkers." -circulation_biomarker_diagnosis_ns hsa-mir-29c "Cardiomyopathy, Hypertrophic" 26086795 "We demonstrated that miR-29a and miR-29c show a specific signature to distinguish between aortic stenosis, hypertrophic non-obstructive and obstructive cardiomyopathies and thus could be developed into clinically useful biomarkers." -circulation_biomarker_diagnosis_ns hsa-mir-505 "Cardiomyopathy, Hypertrophic" 26086795 "We demonstrated that miR-29a and miR-29c show a specific signature to distinguish between aortic stenosis, hypertrophic non-obstructive and obstructive cardiomyopathies and thus could be developed into clinically useful biomarkers." -circulation_biomarker_diagnosis_ns hsa-mir-26a Cholangiocarcinoma 26087181 Serum miR-26a as a diagnostic and prognostic biomarker in cholangiocarcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-143 "Carcinoma, Hepatocellular" 26088272 "A serum microRNA classifier for early detection of hepatocellular carcinoma: a multicentre, retrospective, longitudinal biomarker identification study with a nested case-control study." -circulation_biomarker_diagnosis_ns hsa-mir-145 "Carcinoma, Hepatocellular" 26088272 "A serum microRNA classifier for early detection of hepatocellular carcinoma: a multicentre, retrospective, longitudinal biomarker identification study with a nested case-control study." -circulation_biomarker_diagnosis_ns hsa-mir-192 "Carcinoma, Hepatocellular" 26088272 "A serum microRNA classifier for early detection of hepatocellular carcinoma: a multicentre, retrospective, longitudinal biomarker identification study with a nested case-control study." -circulation_biomarker_diagnosis_ns hsa-mir-29a "Carcinoma, Hepatocellular" 26088272 "A serum microRNA classifier for early detection of hepatocellular carcinoma: a multicentre, retrospective, longitudinal biomarker identification study with a nested case-control study." -circulation_biomarker_diagnosis_ns hsa-mir-29c "Carcinoma, Hepatocellular" 26088272 "A serum microRNA classifier for early detection of hepatocellular carcinoma: a multicentre, retrospective, longitudinal biomarker identification study with a nested case-control study." -circulation_biomarker_diagnosis_ns hsa-mir-505 "Carcinoma, Hepatocellular" 26088272 "A serum microRNA classifier for early detection of hepatocellular carcinoma: a multicentre, retrospective, longitudinal biomarker identification study with a nested case-control study." -circulation_biomarker_diagnosis_ns hsa-mir-126a Acute Pancreatitis 26094040 Serum levels of unique miR-551-5p and endothelial-specific miR-126a-5p allow discrimination of patients in the early phase of acute pancreatitis. -circulation_biomarker_diagnosis_ns hsa-mir-551 Acute Pancreatitis 26094040 Serum levels of unique miR-551-5p and endothelial-specific miR-126a-6p allow discrimination of patients in the early phase of acute pancreatitis. -circulation_biomarker_diagnosis_ns hsa-mir-520d Neoplasms [unspecific] 26094174 "Among HKGs that were expressed in all samples, we suggest that RNU6 and miR-520d-5p were the best candidates for HKGs for studies of plasma miRNA because of the consistent and high Ct in all samples and a very narrow,reproducible SD." -circulation_biomarker_diagnosis_ns hsa-mir-145 Acute Ischemic Stroke 26096228 Circulating miR-145 is associated with plasma high-sensitivity C-reactive protein in acute ischemic stroke patients. -circulation_biomarker_diagnosis_ns hsa-mir-145 Acute Kidney Failure 26106607 "miR-200a/b/c, miR-145, miR-192, miR-194, miR-216a/b, miR-217, and miR-449a expression profiles are useful as biomarkers for identification of various kidney injuries." -circulation_biomarker_diagnosis_ns hsa-mir-192 Acute Kidney Failure 26106607 "miR-200a/b/c, miR-145, miR-192, miR-194, miR-216a/b, miR-217, and miR-449a expression profiles are useful as biomarkers for identification of various kidney injuries." -circulation_biomarker_diagnosis_ns hsa-mir-194 Acute Kidney Failure 26106607 "miR-200a/b/c, miR-145, miR-192, miR-194, miR-216a/b, miR-217, and miR-449a expression profiles are useful as biomarkers for identification of various kidney injuries." -circulation_biomarker_diagnosis_ns hsa-mir-200a Acute Kidney Failure 26106607 "miR-200a/b/c, miR-145, miR-192, miR-194, miR-216a/b, miR-217, and miR-449a expression profiles are useful as biomarkers for identification of various kidney injuries." -circulation_biomarker_diagnosis_ns hsa-mir-200b Acute Kidney Failure 26106607 "miR-200a/b/c, miR-145, miR-192, miR-194, miR-216a/b, miR-217, and miR-449a expression profiles are useful as biomarkers for identification of various kidney injuries." -circulation_biomarker_diagnosis_ns hsa-mir-200c Acute Kidney Failure 26106607 "miR-200a/b/c, miR-145, miR-192, miR-194, miR-216a/b, miR-217, and miR-449a expression profiles are useful as biomarkers for identification of various kidney injuries." -circulation_biomarker_diagnosis_ns hsa-mir-216a Acute Kidney Failure 26106607 "miR-200a/b/c, miR-145, miR-192, miR-194, miR-216a/b, miR-217, and miR-449a expression profiles are useful as biomarkers for identification of various kidney injuries." -circulation_biomarker_diagnosis_ns hsa-mir-216b Acute Kidney Failure 26106607 "miR-200a/b/c, miR-145, miR-192, miR-194, miR-216a/b, miR-217, and miR-449a expression profiles are useful as biomarkers for identification of various kidney injuries." -circulation_biomarker_diagnosis_ns hsa-mir-217 Acute Kidney Failure 26106607 "miR-200a/b/c, miR-145, miR-192, miR-194, miR-216a/b, miR-217, and miR-449a expression profiles are useful as biomarkers for identification of various kidney injuries." -circulation_biomarker_diagnosis_ns hsa-mir-449a Acute Kidney Failure 26106607 "miR-200a/b/c, miR-145, miR-192, miR-194, miR-216a/b, miR-217, and miR-449a expression profiles are useful as biomarkers for identification of various kidney injuries." -circulation_biomarker_diagnosis_ns hsa-mir-21 Lung Neoplasms 26109362 "MiR-21 expression levels in whole blood and peripheral blood cells did not show significant differences between lung cancer patients and healthy controls, and it might be ineffective to measure miR-21 expression to achieve an early diagnosis of lung cancer." -circulation_biomarker_diagnosis_ns hsa-mir-21 Hypertension 26114349 "The decreased levels of NOx and eNOS found in this study indicate the co-existence of endothelial dysfunction and hypertension once more. In the absence of microalbuminuria, the increased miR-21 expression in patients with iCIMT made us conclude that this miRNA might be involved in the early stages of atherosclerotic process in hypertensive patients." -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Hepatocellular" 26114756 Our current findings suggested that circulating miR-21 can serve as a potential co-biomarker for early-stage HCC diagnosis. Thorough large-scale studies are needed to confirm the generalizability of our findings. -circulation_biomarker_diagnosis_ns hsa-mir-15b "Carcinoma, Hepatocellular" 26119771 "Circulating miR-15b-5p, miR-338-5p, and miR-764 may be biomarkers for diagnosis of HCC." -circulation_biomarker_diagnosis_ns hsa-mir-338 "Carcinoma, Hepatocellular" 26119771 "Circulating miR-15b-5p, miR-338-5p, and miR-764 may be biomarkers for diagnosis of HCC." -circulation_biomarker_diagnosis_ns hsa-mir-764 "Carcinoma, Hepatocellular" 26119771 "Circulating miR-15b-5p, miR-338-5p, and miR-764 may be biomarkers for diagnosis of HCC." -circulation_biomarker_diagnosis_ns hsa-mir-144 Breast Neoplasms 26124344 Differentially expressed miRNAs from PBMCs may be potential non-invasive biomarkers for breast cancer prediction. Larger prospective studies are required to confirm whether our findings with specific miRNA loci were related to timing before diagnosis. -circulation_biomarker_diagnosis_ns hsa-mir-183 Breast Neoplasms 26124344 Differentially expressed miRNAs from PBMCs may be potential non-invasive biomarkers for breast cancer prediction. Larger prospective studies are required to confirm whether our findings with specific miRNA loci were related to timing before diagnosis. -circulation_biomarker_diagnosis_ns hsa-mir-451a Breast Neoplasms 26124344 Differentially expressed miRNAs from PBMCs may be potential non-invasive biomarkers for breast cancer prediction. Larger prospective studies are required to confirm whether our findings with specific miRNA loci were related to timing before diagnosis. -circulation_biomarker_diagnosis_ns hsa-mir-708 Breast Neoplasms 26124344 Differentially expressed miRNAs from PBMCs may be potential non-invasive biomarkers for breast cancer prediction. Larger prospective studies are required to confirm whether our findings with specific miRNA loci were related to timing before diagnosis. -circulation_biomarker_diagnosis_ns hsa-mir-146a Chronic Hepatitis B 26131144 Positive correlation was found between the levels of hsa- miR-146a and ALT -circulation_biomarker_diagnosis_ns hsa-mir-122 "Carcinoma, Hepatocellular" 26133725 The combination of serum miR-16 and serum AFP is a significant improvement on the current best practice of serum AFP for HCC in HCVpositive patients. Serum miR-199a and miR-16 could be used as potential indicators of the progress of HCC. -circulation_biomarker_diagnosis_ns hsa-mir-16 "Carcinoma, Hepatocellular" 26133725 The combination of serum miR-16 and serum AFP is a significant improvement on the current best practice of serum AFP for HCC in HCVpositive patients. Serum miR-199a and miR-18 could be used as potential indicators of the progress of HCC. -circulation_biomarker_diagnosis_ns hsa-mir-199a "Carcinoma, Hepatocellular" 26133725 The combination of serum miR-16 and serum AFP is a significant improvement on the current best practice of serum AFP for HCC in HCVpositive patients. Serum miR-199a and miR-17 could be used as potential indicators of the progress of HCC. -circulation_biomarker_diagnosis_ns hsa-mir-103 Colorectal Carcinoma 26134152 Circulating miR-103 and miR-720 as novel serum biomarkers for patients with colorectal cancer. -circulation_biomarker_diagnosis_ns hsa-mir-720 Colorectal Carcinoma 26134152 Circulating miR-103 and miR-720 as novel serum biomarkers for patients with colorectal cancer. -circulation_biomarker_diagnosis_ns hsa-mir-19b "Carcinoma, Lung" 26146958 The assessment of miRs-19b-3p and -29b-3p miRNAs may provide a new diagnostic approach for the early detection of non-small cell lung cancer -circulation_biomarker_diagnosis_ns hsa-mir-100 Coronary Atherosclerosis 26159918 "miR-221, miR-155, miR-100 and hsa-miR-1273,expression level can be used as potential markersfor early coronary atherosclerotic plaque formation." -circulation_biomarker_diagnosis_ns hsa-mir-1273 Coronary Atherosclerosis 26159918 "miR-221, miR-155, miR-100 and hsa-miR-1273,expression level can be used as potential markersfor early coronary atherosclerotic plaque formation." -circulation_biomarker_diagnosis_ns hsa-mir-155 Coronary Atherosclerosis 26159918 "miR-221, miR-155, miR-100 and hsa-miR-1273,expression level can be used as potential markersfor early coronary atherosclerotic plaque formation." -circulation_biomarker_diagnosis_ns hsa-mir-221 Coronary Atherosclerosis 26159918 "miR-221, miR-155, miR-100 and hsa-miR-1273,expression level can be used as potential markersfor early coronary atherosclerotic plaque formation." -circulation_biomarker_diagnosis_ns hsa-mir-103 Prediabetes 26164754 Dysregulated miR-103 and miR-143 expression in peripheral blood mononuclear cells from induced prediabetes and type 2 diabetes rats. -circulation_biomarker_diagnosis_ns hsa-mir-143 Prediabetes 26164754 Dysregulated miR-103 and miR-143 expression in peripheral blood mononuclear cells from induced prediabetes and type 2 diabetes rats. -circulation_biomarker_diagnosis_ns hsa-mir-25 "Carcinoma, Thyroid, Papillary" 26168287 Circulating miR-25-3p and miR-451a May Be Potential Biomarkers for the Diagnosis of Papillary Thyroid Carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-451a "Carcinoma, Thyroid, Papillary" 26168287 Circulating miR-25-3p and miR-451a May Be Potential Biomarkers for the Diagnosis of Papillary Thyroid Carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-141 "Carcinoma, Lung, Non-Small-Cell" 26202143 we identified a serum 4-miRNA signature that discriminated with high accuracy lung cancer patients from NC. Further prospective validation of this miRNA signature is warranted. -circulation_biomarker_diagnosis_ns hsa-mir-193b "Carcinoma, Lung, Non-Small-Cell" 26202143 we identified a serum 4-miRNA signature that discriminated with high accuracy lung cancer patients from NC. Further prospective validation of this miRNA signature is warranted. -circulation_biomarker_diagnosis_ns hsa-mir-200b "Carcinoma, Lung, Non-Small-Cell" 26202143 we identified a serum 4-miRNA signature that discriminated with high accuracy lung cancer patients from NC. Further prospective validation of this miRNA signature is warranted. -circulation_biomarker_diagnosis_ns hsa-mir-301 "Carcinoma, Lung, Non-Small-Cell" 26202143 we identified a serum 4-miRNA signature that discriminated with high accuracy lung cancer patients from NC. Further prospective validation of this miRNA signature is warranted. -circulation_biomarker_diagnosis_ns hsa-mir-200 Endometriosis 26206343 Circulating miR-200-family micro-RNAs have altered plasma levels in patients with endometriosis and vary with blood collection time. -circulation_biomarker_diagnosis_ns hsa-mir-10b Melanoma 26208390 "Evaluation of the expressions pattern of miR-10b, 21, 200c, 373 and 520c to find the correlation between epithelial-to-mesenchymal transition and melanoma stem cell potential in isolated cancer stem cells." -circulation_biomarker_diagnosis_ns hsa-mir-200c Melanoma 26208390 "Evaluation of the expressions pattern of miR-10b, 21, 200c, 373 and 520c to find the correlation between epithelial-to-mesenchymal transition and melanoma stem cell potential in isolated cancer stem cells." -circulation_biomarker_diagnosis_ns hsa-mir-21 Melanoma 26208390 "Evaluation of the expressions pattern of miR-10b, 21, 200c, 373 and 520c to find the correlation between epithelial-to-mesenchymal transition and melanoma stem cell potential in isolated cancer stem cells." -circulation_biomarker_diagnosis_ns hsa-mir-373 Melanoma 26208390 "Evaluation of the expressions pattern of miR-10b, 21, 200c, 373 and 520c to find the correlation between epithelial-to-mesenchymal transition and melanoma stem cell potential in isolated cancer stem cells." -circulation_biomarker_diagnosis_ns hsa-mir-520c Melanoma 26208390 "Evaluation of the expressions pattern of miR-10b, 21, 200c, 373 and 520c to find the correlation between epithelial-to-mesenchymal transition and melanoma stem cell potential in isolated cancer stem cells." -circulation_biomarker_diagnosis_ns hsa-mir-21 Heart Failure 26211628 MiR-21 levels were not different among the groups. -circulation_biomarker_diagnosis_ns hsa-let-7d Systemic Lupus Erythematosus 26225955 MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers. -circulation_biomarker_diagnosis_ns hsa-let-7e Systemic Lupus Erythematosus 26225955 MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-181c Systemic Lupus Erythematosus 26225955 MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-18b Systemic Lupus Erythematosus 26225955 MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-21 Systemic Lupus Erythematosus 26225955 MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-223 Systemic Lupus Erythematosus 26225955 MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-26a Systemic Lupus Erythematosus 26225955 MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-29b Systemic Lupus Erythematosus 26225955 MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-29c Systemic Lupus Erythematosus 26225955 MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-324 Systemic Lupus Erythematosus 26225955 MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-328 Systemic Lupus Erythematosus 26225955 MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-335 Systemic Lupus Erythematosus 26225955 MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-345 Systemic Lupus Erythematosus 26225955 MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-362 Systemic Lupus Erythematosus 26225955 MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-365 Systemic Lupus Erythematosus 26225955 MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-494 Systemic Lupus Erythematosus 26225955 MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-532 Systemic Lupus Erythematosus 26225955 MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-579 Systemic Lupus Erythematosus 26225955 MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-629 Systemic Lupus Erythematosus 26225955 MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-744 Systemic Lupus Erythematosus 26225955 MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-21 Intestinal Schistosomiasis 26230095 "The inconsistent levels of the host circulating miRNAs, miR-122, miR-21 and miR-34a in serum were confirmed in the two murine models during infection" -circulation_biomarker_diagnosis_ns hsa-mir-486 "Carcinoma, Lung, Non-Small-Cell" 26237047 The results suggest that miR-486 and miR-150 could be potential blood-based biomarkers for early diagnosis of NSCLC. Monitoring change of miR-486 expression in plasma might be an effective and non-invasive method for recurrence prediction of early-staged NSCLC patients. -circulation_biomarker_diagnosis_ns hsa-mir-146b Synovial Sarcoma 26250552 "Our results have identified a specific whole blood miRNA signature that may serve as an independent biomarker for the diagnosis of local recurrence or distant metastasis of synovial sarcoma. It even distinguishes synovial sarcoma from other sarcoma subtypes, thus potentially serving as a specific biomarker for synovial sarcoma." -circulation_biomarker_diagnosis_ns hsa-mir-148b Synovial Sarcoma 26250552 "Our results have identified a specific whole blood miRNA signature that may serve as an independent biomarker for the diagnosis of local recurrence or distant metastasis of synovial sarcoma. It even distinguishes synovial sarcoma from other sarcoma subtypes, thus potentially serving as a specific biomarker for synovial sarcoma." -circulation_biomarker_diagnosis_ns hsa-mir-195 Synovial Sarcoma 26250552 "Our results have identified a specific whole blood miRNA signature that may serve as an independent biomarker for the diagnosis of local recurrence or distant metastasis of synovial sarcoma. It even distinguishes synovial sarcoma from other sarcoma subtypes, thus potentially serving as a specific biomarker for synovial sarcoma." -circulation_biomarker_diagnosis_ns hsa-mir-223 Synovial Sarcoma 26250552 "Our results have identified a specific whole blood miRNA signature that may serve as an independent biomarker for the diagnosis of local recurrence or distant metastasis of synovial sarcoma. It even distinguishes synovial sarcoma from other sarcoma subtypes, thus potentially serving as a specific biomarker for synovial sarcoma." -circulation_biomarker_diagnosis_ns hsa-mir-500b Synovial Sarcoma 26250552 "Our results have identified a specific whole blood miRNA signature that may serve as an independent biomarker for the diagnosis of local recurrence or distant metastasis of synovial sarcoma. It even distinguishes synovial sarcoma from other sarcoma subtypes, thus potentially serving as a specific biomarker for synovial sarcoma." -circulation_biomarker_diagnosis_ns hsa-mir-505 Synovial Sarcoma 26250552 "Our results have identified a specific whole blood miRNA signature that may serve as an independent biomarker for the diagnosis of local recurrence or distant metastasis of synovial sarcoma. It even distinguishes synovial sarcoma from other sarcoma subtypes, thus potentially serving as a specific biomarker for synovial sarcoma." -circulation_biomarker_diagnosis_ns hsa-mir-99a Synovial Sarcoma 26250552 "Our results have identified a specific whole blood miRNA signature that may serve as an independent biomarker for the diagnosis of local recurrence or distant metastasis of synovial sarcoma. It even distinguishes synovial sarcoma from other sarcoma subtypes, thus potentially serving as a specific biomarker for synovial sarcoma." -circulation_biomarker_diagnosis_ns hsa-mir-210 Bladder Neoplasms 26252880 "Serum miR-210 Contributes to Tumor Detection, Stage Prediction and Dynamic Surveillance in Patients with Bladder Cancer." -circulation_biomarker_diagnosis_ns hsa-mir-192 Nephrotic Syndrome 26261628 Differential microRNA expression in the serum of patients with nephrotic syndrome and clinical correlation analysis. -circulation_biomarker_diagnosis_ns hsa-mir-210 Nephrotic Syndrome 26261628 Differential microRNA expression in the serum of patients with nephrotic syndrome and clinical correlation analysis. -circulation_biomarker_diagnosis_ns hsa-mir-30a Nephrotic Syndrome 26261628 Differential microRNA expression in the serum of patients with nephrotic syndrome and clinical correlation analysis. -circulation_biomarker_diagnosis_ns hsa-mir-586 Nephrotic Syndrome 26261628 Differential microRNA expression in the serum of patients with nephrotic syndrome and clinical correlation analysis. -circulation_biomarker_diagnosis_ns hsa-mir-942 Nephrotic Syndrome 26261628 Differential microRNA expression in the serum of patients with nephrotic syndrome and clinical correlation analysis. -circulation_biomarker_diagnosis_ns hsa-mir-21 "Adenocarcinoma, Pancreatic Ductal" 26262588 "Serum miR-21 and miR-34a are potentially useful diagnostic biomarkers of PDAC. In addition, our results suggest that these miRNAs are not differentially expressed in saliva, making them unsuitable for use as noninvasive biomarkers for diagnostic purposes." -circulation_biomarker_diagnosis_ns hsa-mir-34a "Adenocarcinoma, Pancreatic Ductal" 26262588 "Serum miR-21 and miR-34a are potentially useful diagnostic biomarkers of PDAC. In addition, our results suggest that these miRNAs are not differentially expressed in saliva, making them unsuitable for use as noninvasive biomarkers for diagnostic purposes." -circulation_biomarker_diagnosis_ns hsa-mir-143 "Carcinoma, Hepatocellular, HBV-Related" 26267843 "The miRNA expression profile of PBMCs is altered in patients with HBV-ACLF, and a signature of six miRNAs may be a promising biomarker for HBV-ACLF progression." -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Hepatocellular, HBV-Related" 26267843 "The miRNA expression profile of PBMCs is altered in patients with HBV-ACLF, and a signature of six miRNAs may be a promising biomarker for HBV-ACLF progression." -circulation_biomarker_diagnosis_ns hsa-mir-34c "Carcinoma, Hepatocellular, HBV-Related" 26267843 "The miRNA expression profile of PBMCs is altered in patients with HBV-ACLF, and a signature of six miRNAs may be a promising biomarker for HBV-ACLF progression." -circulation_biomarker_diagnosis_ns hsa-mir-374a "Carcinoma, Hepatocellular, HBV-Related" 26267843 "The miRNA expression profile of PBMCs is altered in patients with HBV-ACLF, and a signature of six miRNAs may be a promising biomarker for HBV-ACLF progression." -circulation_biomarker_diagnosis_ns hsa-mir-542 "Carcinoma, Hepatocellular, HBV-Related" 26267843 "The miRNA expression profile of PBMCs is altered in patients with HBV-ACLF, and a signature of six miRNAs may be a promising biomarker for HBV-ACLF progression." -circulation_biomarker_diagnosis_ns hsa-mir-155 "Carcinoma, Hepatocellular, HCV-Related" 26272105 "This study shows that some microRNAs are differently expressed in peripheral blood mononuclear cells from hepatitis C virus patients who develop hepatocellular carcinoma or lymphoma, while others share a common behavior. Thus,analysis of the expression of microRNAs could be a noninvasive marker of hepatitis C virus-related carcinogenesis. This analysis could be a suitable tool for identifying the existence of a malignancy and also discriminating between these two hepatitis C virus-related cancers." -circulation_biomarker_diagnosis_ns hsa-mir-16 "Carcinoma, Hepatocellular, HCV-Related" 26272105 "This study shows that some microRNAs are differently expressed in peripheral blood mononuclear cells from hepatitis C virus patients who develop hepatocellular carcinoma or lymphoma, while others share a common behavior. Thus,analysis of the expression of microRNAs could be a noninvasive marker of hepatitis C virus-related carcinogenesis. This analysis could be a suitable tool for identifying the existence of a malignancy and also discriminating between these two hepatitis C virus-related cancers." -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Hepatocellular, HCV-Related" 26272105 "This study shows that some microRNAs are differently expressed in peripheral blood mononuclear cells from hepatitis C virus patients who develop hepatocellular carcinoma or lymphoma, while others share a common behavior. Thus,analysis of the expression of microRNAs could be a noninvasive marker of hepatitis C virus-related carcinogenesis. This analysis could be a suitable tool for identifying the existence of a malignancy and also discriminating between these two hepatitis C virus-related cancers." -circulation_biomarker_diagnosis_ns hsa-mir-26b "Carcinoma, Hepatocellular, HCV-Related" 26272105 "This study shows that some microRNAs are differently expressed in peripheral blood mononuclear cells from hepatitis C virus patients who develop hepatocellular carcinoma or lymphoma, while others share a common behavior. Thus,analysis of the expression of microRNAs could be a noninvasive marker of hepatitis C virus-related carcinogenesis. This analysis could be a suitable tool for identifying the existence of a malignancy and also discriminating between these two hepatitis C virus-related cancers." -circulation_biomarker_diagnosis_ns hsa-mir-183 "Carcinoma, Hepatocellular" 26278140 "Sensitivity and specificity of miR-183 as a diagnostic marker of HCC were 57.9% and 76.2% in serum, and 78.9% and 81.0% in plasma" -circulation_biomarker_diagnosis_ns hsa-mir-122 Hepatitis C Virus Infection 26283876 Dysregulated Serum MicroRNA Expression Profile and Potential Biomarkers in Hepatitis C Virus-infected Patients. -circulation_biomarker_diagnosis_ns hsa-mir-134 Hepatitis C Virus Infection 26283876 Dysregulated Serum MicroRNA Expression Profile and Potential Biomarkers in Hepatitis C Virus-infected Patients. -circulation_biomarker_diagnosis_ns hsa-mir-424 Hepatitis C Virus Infection 26283876 Dysregulated Serum MicroRNA Expression Profile and Potential Biomarkers in Hepatitis C Virus-infected Patients. -circulation_biomarker_diagnosis_ns hsa-mir-629 Hepatitis C Virus Infection 26283876 Dysregulated Serum MicroRNA Expression Profile and Potential Biomarkers in Hepatitis C Virus-infected Patients. -circulation_biomarker_diagnosis_ns hsa-mir-21 Glioma 26284486 "Therefore, we concluded that the exosomal miR-21 levels could be demonstrated as a promising indicator for glioma diagnosis and prognosis, particularly with values to predict tumor recurrence or metastasis." -circulation_biomarker_diagnosis_ns hsa-mir-150 Melanoma 26288839 This panel was found to be superior to currently used serological markers for melanoma progression -circulation_biomarker_diagnosis_ns hsa-mir-15b Melanoma 26288839 This panel was found to be superior to currently used serological markers for melanoma progression -circulation_biomarker_diagnosis_ns hsa-mir-199a Melanoma 26288839 This panel was found to be superior to currently used serological markers for melanoma progression -circulation_biomarker_diagnosis_ns hsa-mir-211 Melanoma 26288839 This panel was found to be superior to currently used serological markers for melanoma progression -circulation_biomarker_diagnosis_ns hsa-mir-33a Melanoma 26288839 This panel was found to be superior to currently used serological markers for melanoma progression -circulation_biomarker_diagnosis_ns hsa-mir-424 Melanoma 26288839 This panel was found to be superior to currently used serological markers for melanoma progression -circulation_biomarker_diagnosis_ns hsa-mir-4487 Melanoma 26288839 This panel was found to be superior to currently used serological markers for melanoma progression -circulation_biomarker_diagnosis_ns hsa-mir-4706 Melanoma 26288839 This panel was found to be superior to currently used serological markers for melanoma progression -circulation_biomarker_diagnosis_ns hsa-mir-4731 Melanoma 26288839 This panel was found to be superior to currently used serological markers for melanoma progression -circulation_biomarker_diagnosis_ns hsa-mir-506 Melanoma 26288839 This panel was found to be superior to currently used serological markers for melanoma progression -circulation_biomarker_diagnosis_ns hsa-mir-509 Melanoma 26288839 This panel was found to be superior to currently used serological markers for melanoma progression -circulation_biomarker_diagnosis_ns hsa-mir-514 Melanoma 26288839 This panel was found to be superior to currently used serological markers for melanoma progression -circulation_biomarker_diagnosis_ns hsa-mir-514a Melanoma 26288839 This panel was found to be superior to currently used serological markers for melanoma progression -circulation_biomarker_diagnosis_ns hsa-mir-17 Bronchopulmonary Dysplasia 26291337 Our data are the first to demonstrate altered expression of the miR-17-92 cluster in bronchopulmonary dysplasia. The consistency between our autopsy and plasma findings further support our working hypothesis that the miR-17-92 cluster contributes to the molecular pathogenesis of bronchopulmonary dysplasia. -circulation_biomarker_diagnosis_ns hsa-mir-367 Neoplasms [unspecific] 26306513 Targeted miRNA-based blood tests for miR-371-3 and miR-367 clusters are currently under development and hold a great promise for the future. -circulation_biomarker_diagnosis_ns hsa-mir-185 "Squamous Cell Carcinoma, Esophageal" 26316588 "In conclusion, our findings shed novel light on the role of miR-185/RAGE in ESCC metastasis, and plasma miR-185 has potential as a novel diagnostic biomarker in ESCC." -circulation_biomarker_diagnosis_ns hsa-mir-196b "Leukemia, Myeloid, Acute" 26317787 "These results suggest that microRNA-155 is a potential diagnostic biomarker for all subgroups of paediatric AML, whereas microRNA-196b is specific for subgroups M4-M5." -circulation_biomarker_diagnosis_ns hsa-mir-210 Chronic Hepatitis B 26319884 "Serum miR-210 can be used as an indicator of HBV replication and translation, and a potential marker of necroinflammation in patients with CHB." -circulation_biomarker_diagnosis_ns hsa-mir-191 "Carcinoma, Urothelial, Upper Tract" 26323574 Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection. -circulation_biomarker_diagnosis_ns hsa-mir-22 "Carcinoma, Urothelial, Upper Tract" 26323574 Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection. -circulation_biomarker_diagnosis_ns hsa-mir-26a "Carcinoma, Urothelial, Upper Tract" 26323574 Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection. -circulation_biomarker_diagnosis_ns hsa-mir-33b "Carcinoma, Urothelial, Upper Tract" 26323574 Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection. -circulation_biomarker_diagnosis_ns hsa-mir-423 "Carcinoma, Urothelial, Upper Tract" 26323574 Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection. -circulation_biomarker_diagnosis_ns hsa-mir-431 "Carcinoma, Urothelial, Upper Tract" 26323574 Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection. -circulation_biomarker_diagnosis_ns hsa-mir-664a "Carcinoma, Urothelial, Upper Tract" 26323574 Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection. -circulation_biomarker_diagnosis_ns hsa-mir-92a "Carcinoma, Urothelial, Upper Tract" 26323574 Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection. -circulation_biomarker_diagnosis_ns hsa-let-7b Atherosclerosis 26333279 "A specific circulating miRNAs profile is associated with migraine without aura. Remarkably, the same miRNAs are known to be modulated in the setting of atherosclerosis and stroke in humans. This study represents a first step towards further characterization of MO diagnosis/pathophysiology, also in relation to its link with cardiovascular risk." -circulation_biomarker_diagnosis_ns hsa-let-7b Stroke 26333279 "A specific circulating miRNAs profile is associated with migraine without aura. Remarkably, the same miRNAs are known to be modulated in the setting of atherosclerosis and stroke in humans. This study represents a first step towards further characterization of MO diagnosis/pathophysiology, also in relation to its link with cardiovascular risk." -circulation_biomarker_diagnosis_ns hsa-mir-22 Atherosclerosis 26333279 "A specific circulating miRNAs profile is associated with migraine without aura. Remarkably, the same miRNAs are known to be modulated in the setting of atherosclerosis and stroke in humans. This study represents a first step towards further characterization of MO diagnosis/pathophysiology, also in relation to its link with cardiovascular risk." -circulation_biomarker_diagnosis_ns hsa-mir-22 Stroke 26333279 "A specific circulating miRNAs profile is associated with migraine without aura. Remarkably, the same miRNAs are known to be modulated in the setting of atherosclerosis and stroke in humans. This study represents a first step towards further characterization of MO diagnosis/pathophysiology, also in relation to its link with cardiovascular risk." -circulation_biomarker_diagnosis_ns hsa-mir-221 Atherosclerosis 26333279 "A specific circulating miRNAs profile is associated with migraine without aura. Remarkably, the same miRNAs are known to be modulated in the setting of atherosclerosis and stroke in humans. This study represents a first step towards further characterization of MO diagnosis/pathophysiology, also in relation to its link with cardiovascular risk." -circulation_biomarker_diagnosis_ns hsa-mir-221 Stroke 26333279 "A specific circulating miRNAs profile is associated with migraine without aura. Remarkably, the same miRNAs are known to be modulated in the setting of atherosclerosis and stroke in humans. This study represents a first step towards further characterization of MO diagnosis/pathophysiology, also in relation to its link with cardiovascular risk." -circulation_biomarker_diagnosis_ns hsa-mir-26a Atherosclerosis 26333279 "A specific circulating miRNAs profile is associated with migraine without aura. Remarkably, the same miRNAs are known to be modulated in the setting of atherosclerosis and stroke in humans. This study represents a first step towards further characterization of MO diagnosis/pathophysiology, also in relation to its link with cardiovascular risk." -circulation_biomarker_diagnosis_ns hsa-mir-26a Stroke 26333279 "A specific circulating miRNAs profile is associated with migraine without aura. Remarkably, the same miRNAs are known to be modulated in the setting of atherosclerosis and stroke in humans. This study represents a first step towards further characterization of MO diagnosis/pathophysiology, also in relation to its link with cardiovascular risk." -circulation_biomarker_diagnosis_ns hsa-mir-26b Atherosclerosis 26333279 "A specific circulating miRNAs profile is associated with migraine without aura. Remarkably, the same miRNAs are known to be modulated in the setting of atherosclerosis and stroke in humans. This study represents a first step towards further characterization of MO diagnosis/pathophysiology, also in relation to its link with cardiovascular risk." -circulation_biomarker_diagnosis_ns hsa-mir-26b Stroke 26333279 "A specific circulating miRNAs profile is associated with migraine without aura. Remarkably, the same miRNAs are known to be modulated in the setting of atherosclerosis and stroke in humans. This study represents a first step towards further characterization of MO diagnosis/pathophysiology, also in relation to its link with cardiovascular risk." -circulation_biomarker_diagnosis_ns hsa-mir-27b Atherosclerosis 26333279 "A specific circulating miRNAs profile is associated with migraine without aura. Remarkably, the same miRNAs are known to be modulated in the setting of atherosclerosis and stroke in humans. This study represents a first step towards further characterization of MO diagnosis/pathophysiology, also in relation to its link with cardiovascular risk." -circulation_biomarker_diagnosis_ns hsa-mir-27b Stroke 26333279 "A specific circulating miRNAs profile is associated with migraine without aura. Remarkably, the same miRNAs are known to be modulated in the setting of atherosclerosis and stroke in humans. This study represents a first step towards further characterization of MO diagnosis/pathophysiology, also in relation to its link with cardiovascular risk." -circulation_biomarker_diagnosis_ns hsa-mir-29b Atherosclerosis 26333279 "A specific circulating miRNAs profile is associated with migraine without aura. Remarkably, the same miRNAs are known to be modulated in the setting of atherosclerosis and stroke in humans. This study represents a first step towards further characterization of MO diagnosis/pathophysiology, also in relation to its link with cardiovascular risk." -circulation_biomarker_diagnosis_ns hsa-mir-29b Stroke 26333279 "A specific circulating miRNAs profile is associated with migraine without aura. Remarkably, the same miRNAs are known to be modulated in the setting of atherosclerosis and stroke in humans. This study represents a first step towards further characterization of MO diagnosis/pathophysiology, also in relation to its link with cardiovascular risk." -circulation_biomarker_diagnosis_ns hsa-mir-30b Atherosclerosis 26333279 "A specific circulating miRNAs profile is associated with migraine without aura. Remarkably, the same miRNAs are known to be modulated in the setting of atherosclerosis and stroke in humans. This study represents a first step towards further characterization of MO diagnosis/pathophysiology, also in relation to its link with cardiovascular risk." -circulation_biomarker_diagnosis_ns hsa-mir-30b Stroke 26333279 "A specific circulating miRNAs profile is associated with migraine without aura. Remarkably, the same miRNAs are known to be modulated in the setting of atherosclerosis and stroke in humans. This study represents a first step towards further characterization of MO diagnosis/pathophysiology, also in relation to its link with cardiovascular risk." -circulation_biomarker_diagnosis_ns hsa-mir-30e Atherosclerosis 26333279 "A specific circulating miRNAs profile is associated with migraine without aura. Remarkably, the same miRNAs are known to be modulated in the setting of atherosclerosis and stroke in humans. This study represents a first step towards further characterization of MO diagnosis/pathophysiology, also in relation to its link with cardiovascular risk." -circulation_biomarker_diagnosis_ns hsa-mir-30e Stroke 26333279 "A specific circulating miRNAs profile is associated with migraine without aura. Remarkably, the same miRNAs are known to be modulated in the setting of atherosclerosis and stroke in humans. This study represents a first step towards further characterization of MO diagnosis/pathophysiology, also in relation to its link with cardiovascular risk." -circulation_biomarker_diagnosis_ns hsa-mir-146a Myocardial Infarction 26337652 Circulating miR-146a and miR-21 may be novel biomarkers predictive of LVR after acute MI. Their combination may better predict LVR than either alone. -circulation_biomarker_diagnosis_ns hsa-mir-21 Myocardial Infarction 26337652 Circulating miR-146a and miR-21 may be novel biomarkers predictive of LVR after acute MI. Their combination may better predict LVR than either alone. -circulation_biomarker_diagnosis_ns hsa-let-7b "Carcinoma, Thyroid, Papillary" 26341226 MicroRNA is differentially expressed in the serum of patients with PTC. Serum miRNA has the potential to aid in thyroid cancer diagnosis. -circulation_biomarker_diagnosis_ns hsa-mir-10a "Carcinoma, Thyroid, Papillary" 26341226 MicroRNA is differentially expressed in the serum of patients with PTC. Serum miRNA has the potential to aid in thyroid cancer diagnosis. -circulation_biomarker_diagnosis_ns hsa-mir-146a "Carcinoma, Thyroid, Papillary" 26341226 MicroRNA is differentially expressed in the serum of patients with PTC. Serum miRNA has the potential to aid in thyroid cancer diagnosis. -circulation_biomarker_diagnosis_ns hsa-mir-199b "Carcinoma, Thyroid, Papillary" 26341226 MicroRNA is differentially expressed in the serum of patients with PTC. Serum miRNA has the potential to aid in thyroid cancer diagnosis. -circulation_biomarker_diagnosis_ns hsa-mir-27a Acute Heart Failure 26345695 Fifteen miRNAs found in the discovery phase to differ most significantly between healthy controls and patients with AHF -circulation_biomarker_diagnosis_ns hsa-mir-1 Essential Hypertension 26358152 Hypertrophic and antihypertrophic microRNA levels in peripheral blood mononuclear cells and their relationship to left ventricular hypertrophy in patients with essential hypertension. -circulation_biomarker_diagnosis_ns hsa-mir-133a Essential Hypertension 26358152 Hypertrophic and antihypertrophic microRNA levels in peripheral blood mononuclear cells and their relationship to left ventricular hypertrophy in patients with essential hypertension. -circulation_biomarker_diagnosis_ns hsa-mir-208b Essential Hypertension 26358152 Hypertrophic and antihypertrophic microRNA levels in peripheral blood mononuclear cells and their relationship to left ventricular hypertrophy in patients with essential hypertension. -circulation_biomarker_diagnosis_ns hsa-mir-21 Essential Hypertension 26358152 Hypertrophic and antihypertrophic microRNA levels in peripheral blood mononuclear cells and their relationship to left ventricular hypertrophy in patients with essential hypertension. -circulation_biomarker_diagnosis_ns hsa-mir-26b Essential Hypertension 26358152 Hypertrophic and antihypertrophic microRNA levels in peripheral blood mononuclear cells and their relationship to left ventricular hypertrophy in patients with essential hypertension. -circulation_biomarker_diagnosis_ns hsa-mir-499 Essential Hypertension 26358152 Hypertrophic and antihypertrophic microRNA levels in peripheral blood mononuclear cells and their relationship to left ventricular hypertrophy in patients with essential hypertension. -circulation_biomarker_diagnosis_ns hsa-mir-26a Osteosarcoma 26377680 "In conclusion, our findings suggested that expression level of miR-26a and miR-27a contributes to aggressive progression of this malignancy.Therefore, may have clinical potentials as a non-invasive diagnostic/prognostic biomarker for osteosarcoma patients." -circulation_biomarker_diagnosis_ns hsa-mir-27a Osteosarcoma 26377680 "In conclusion, our findings suggested that expression level of miR-26a and miR-27a contributes to aggressive progression of this malignancy.Therefore, may have clinical potentials as a non-invasive diagnostic/prognostic biomarker for osteosarcoma patients." -circulation_biomarker_diagnosis_ns hsa-mir-146a Epilepsy 26382856 "Those miRNAs that are altered in plasma before the first spontaneous seizure,like miR-9a-3p, may be proposed as putative biomarkers of epileptogenesis." -circulation_biomarker_diagnosis_ns hsa-mir-181c Epilepsy 26382856 "Those miRNAs that are altered in plasma before the first spontaneous seizure,like miR-9a-3p, may be proposed as putative biomarkers of epileptogenesis." -circulation_biomarker_diagnosis_ns hsa-mir-21 Epilepsy 26382856 "Those miRNAs that are altered in plasma before the first spontaneous seizure,like miR-9a-3p, may be proposed as putative biomarkers of epileptogenesis." -circulation_biomarker_diagnosis_ns hsa-mir-23a Epilepsy 26382856 "Those miRNAs that are altered in plasma before the first spontaneous seizure,like miR-9a-3p, may be proposed as putative biomarkers of epileptogenesis." -circulation_biomarker_diagnosis_ns hsa-mir-9a Epilepsy 26382856 "Those miRNAs that are altered in plasma before the first spontaneous seizure,like miR-9a-3p, may be proposed as putative biomarkers of epileptogenesis." -circulation_biomarker_diagnosis_ns hsa-mir-103 Obesity 26406295 This study provides the first identification of altered circulating miRNAs in maternal obesity and suggests a possible role of such miRNAS as markers for pre- and postnatal growth. -circulation_biomarker_diagnosis_ns hsa-mir-122 Obesity 26406295 This study provides the first identification of altered circulating miRNAs in maternal obesity and suggests a possible role of such miRNAS as markers for pre- and postnatal growth. -circulation_biomarker_diagnosis_ns hsa-mir-130a Obesity 26406295 This study provides the first identification of altered circulating miRNAs in maternal obesity and suggests a possible role of such miRNAS as markers for pre- and postnatal growth. -circulation_biomarker_diagnosis_ns hsa-mir-150 Obesity 26406295 This study provides the first identification of altered circulating miRNAs in maternal obesity and suggests a possible role of such miRNAS as markers for pre- and postnatal growth. -circulation_biomarker_diagnosis_ns hsa-mir-221 Obesity 26406295 This study provides the first identification of altered circulating miRNAs in maternal obesity and suggests a possible role of such miRNAS as markers for pre- and postnatal growth. -circulation_biomarker_diagnosis_ns hsa-mir-29c Obesity 26406295 This study provides the first identification of altered circulating miRNAs in maternal obesity and suggests a possible role of such miRNAS as markers for pre- and postnatal growth. -circulation_biomarker_diagnosis_ns hsa-mir-30a Obesity 26406295 This study provides the first identification of altered circulating miRNAs in maternal obesity and suggests a possible role of such miRNAS as markers for pre- and postnatal growth. -circulation_biomarker_diagnosis_ns hsa-mir-324 Obesity 26406295 This study provides the first identification of altered circulating miRNAs in maternal obesity and suggests a possible role of such miRNAS as markers for pre- and postnatal growth. -circulation_biomarker_diagnosis_ns hsa-mir-340 Obesity 26406295 This study provides the first identification of altered circulating miRNAs in maternal obesity and suggests a possible role of such miRNAS as markers for pre- and postnatal growth. -circulation_biomarker_diagnosis_ns hsa-mir-375 Obesity 26406295 This study provides the first identification of altered circulating miRNAs in maternal obesity and suggests a possible role of such miRNAS as markers for pre- and postnatal growth. -circulation_biomarker_diagnosis_ns hsa-mir-652 Obesity 26406295 This study provides the first identification of altered circulating miRNAs in maternal obesity and suggests a possible role of such miRNAS as markers for pre- and postnatal growth. -circulation_biomarker_diagnosis_ns hsa-mir-99b Obesity 26406295 This study provides the first identification of altered circulating miRNAs in maternal obesity and suggests a possible role of such miRNAS as markers for pre- and postnatal growth. -circulation_biomarker_diagnosis_ns hsa-let-7e "Stroke, Ischemic" 26415639 MicroRNA let-7e Is a Potential Circulating Biomarker of Acute Stage Ischemic Stroke. -circulation_biomarker_diagnosis_ns hsa-mir-210 "Carcinoma, Renal Cell" 26426010 Combination of MiR-378 and MiR-210 Serum Levels Enables Sensitive Detection of Renal Cell Carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-378 "Carcinoma, Renal Cell" 26426010 Combination of MiR-378 and MiR-210 Serum Levels Enables Sensitive Detection of Renal Cell Carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-3151 "Leukemia, Myeloid, Acute" 26430723 "In conclusion, the analysis of miR-3151 and BAALC expression may well contribute to an improved prognostic stratification of younger patients with IR-AML." -circulation_biomarker_diagnosis_ns hsa-let-7i Heart Failure 26430739 "Our data show a different miR expression pattern after LVAD support, suggesting that differentially expressed miRs are partially responsible for the cardiac morphological and functional changes observed after support. However, the miR expression patterns do not seem to significantly differ between pf- and cf-LVAD implying that most cardiac changes or clinical outcomes specific to each device do not relate to differences in miR expression levels." -circulation_biomarker_diagnosis_ns hsa-mir-129 Heart Failure 26430739 "Our data show a different miR expression pattern after LVAD support, suggesting that differentially expressed miRs are partially responsible for the cardiac morphological and functional changes observed after support. However, the miR expression patterns do not seem to significantly differ between pf- and cf-LVAD implying that most cardiac changes or clinical outcomes specific to each device do not relate to differences in miR expression levels." -circulation_biomarker_diagnosis_ns hsa-mir-146a Heart Failure 26430739 "Our data show a different miR expression pattern after LVAD support, suggesting that differentially expressed miRs are partially responsible for the cardiac morphological and functional changes observed after support. However, the miR expression patterns do not seem to significantly differ between pf- and cf-LVAD implying that most cardiac changes or clinical outcomes specific to each device do not relate to differences in miR expression levels." -circulation_biomarker_diagnosis_ns hsa-mir-155 Heart Failure 26430739 "Our data show a different miR expression pattern after LVAD support, suggesting that differentially expressed miRs are partially responsible for the cardiac morphological and functional changes observed after support. However, the miR expression patterns do not seem to significantly differ between pf- and cf-LVAD implying that most cardiac changes or clinical outcomes specific to each device do not relate to differences in miR expression levels." -circulation_biomarker_diagnosis_ns hsa-mir-21 Heart Failure 26430739 "Our data show a different miR expression pattern after LVAD support, suggesting that differentially expressed miRs are partially responsible for the cardiac morphological and functional changes observed after support. However, the miR expression patterns do not seem to significantly differ between pf- and cf-LVAD implying that most cardiac changes or clinical outcomes specific to each device do not relate to differences in miR expression levels." -circulation_biomarker_diagnosis_ns hsa-mir-221 Heart Failure 26430739 "Our data show a different miR expression pattern after LVAD support, suggesting that differentially expressed miRs are partially responsible for the cardiac morphological and functional changes observed after support. However, the miR expression patterns do not seem to significantly differ between pf- and cf-LVAD implying that most cardiac changes or clinical outcomes specific to each device do not relate to differences in miR expression levels." -circulation_biomarker_diagnosis_ns hsa-mir-222 Heart Failure 26430739 "Our data show a different miR expression pattern after LVAD support, suggesting that differentially expressed miRs are partially responsible for the cardiac morphological and functional changes observed after support. However, the miR expression patterns do not seem to significantly differ between pf- and cf-LVAD implying that most cardiac changes or clinical outcomes specific to each device do not relate to differences in miR expression levels." -circulation_biomarker_diagnosis_ns hsa-mir-378 Heart Failure 26430739 "Our data show a different miR expression pattern after LVAD support, suggesting that differentially expressed miRs are partially responsible for the cardiac morphological and functional changes observed after support. However, the miR expression patterns do not seem to significantly differ between pf- and cf-LVAD implying that most cardiac changes or clinical outcomes specific to each device do not relate to differences in miR expression levels." -circulation_biomarker_diagnosis_ns hsa-mir-200 "Carcinoma, Hepatocellular" 26447841 Circulating microRNA-200 family members are significantly deregulated in patients with HCC and liver cirrhosis. Further studies are necessary to confirm the diagnostic value of the microRNA-200 family as accurate serum marker for cirrhosis-associated HCC. -circulation_biomarker_diagnosis_ns hsa-mir-185 Glioma 26458593 These findings suggest that plasma miR-185 has become potential biomarkers for glioma and may be useful in clinical management for glioma patients. -circulation_biomarker_diagnosis_ns hsa-mir-126 Chronic Kidney Disease 26475583 Plasma levels of microRNA in chronic kidney disease: patterns in acute and chronic exercise. -circulation_biomarker_diagnosis_ns hsa-mir-146a Chronic Kidney Disease 26475583 Plasma levels of microRNA in chronic kidney disease: patterns in acute and chronic exercise. -circulation_biomarker_diagnosis_ns hsa-mir-150 Chronic Kidney Disease 26475583 Plasma levels of microRNA in chronic kidney disease: patterns in acute and chronic exercise. -circulation_biomarker_diagnosis_ns hsa-mir-21 Chronic Kidney Disease 26475583 Plasma levels of microRNA in chronic kidney disease: patterns in acute and chronic exercise. -circulation_biomarker_diagnosis_ns hsa-mir-210 Chronic Kidney Disease 26475583 Plasma levels of microRNA in chronic kidney disease: patterns in acute and chronic exercise. -circulation_biomarker_diagnosis_ns hsa-mir-199a Breast Neoplasms 26476723 "Our data demonstrate that the SdM-RT-PCR assay is an effective breast cancer profiling method that utilizes very small volumes and is compatible with Biobank.Furthermore, the identified 3-miRNA signature is a promising circulating biomarker for breast cancer diagnosis." -circulation_biomarker_diagnosis_ns hsa-mir-29c Breast Neoplasms 26476723 "Our data demonstrate that the SdM-RT-PCR assay is an effective breast cancer profiling method that utilizes very small volumes and is compatible with Biobank.Furthermore, the identified 3-miRNA signature is a promising circulating biomarker for breast cancer diagnosis." -circulation_biomarker_diagnosis_ns hsa-mir-424 Breast Neoplasms 26476723 "Our data demonstrate that the SdM-RT-PCR assay is an effective breast cancer profiling method that utilizes very small volumes and is compatible with Biobank.Furthermore, the identified 3-miRNA signature is a promising circulating biomarker for breast cancer diagnosis." -circulation_biomarker_diagnosis_ns hsa-mir-10a Chronic Hepatitis B 26483130 We constructed serum miRNA panels with considerable clinical value in diagnosing PNALT. -circulation_biomarker_diagnosis_ns hsa-mir-122 Chronic Hepatitis B 26483130 We constructed serum miRNA panels with considerable clinical value in diagnosing PNALT. -circulation_biomarker_diagnosis_ns hsa-mir-192 Chronic Hepatitis B 26483130 We constructed serum miRNA panels with considerable clinical value in diagnosing PNALT. -circulation_biomarker_diagnosis_ns hsa-mir-26a Chronic Hepatitis B 26483130 We constructed serum miRNA panels with considerable clinical value in diagnosing PNALT. -circulation_biomarker_diagnosis_ns hsa-mir-30b Chronic Hepatitis B 26483130 We constructed serum miRNA panels with considerable clinical value in diagnosing PNALT. -circulation_biomarker_diagnosis_ns hsa-mir-511 Chronic Hepatitis B 26483130 We constructed serum miRNA panels with considerable clinical value in diagnosing PNALT. -circulation_biomarker_diagnosis_ns hsa-mir-574 Chronic Hepatitis B 26483130 We constructed serum miRNA panels with considerable clinical value in diagnosing PNALT. -circulation_biomarker_diagnosis_ns hsa-mir-885 Chronic Hepatitis B 26483130 We constructed serum miRNA panels with considerable clinical value in diagnosing PNALT. -circulation_biomarker_diagnosis_ns hsa-mir-98 Chronic Hepatitis B 26483130 We constructed serum miRNA panels with considerable clinical value in diagnosing PNALT. -circulation_biomarker_diagnosis_ns hsa-mir-339 Ovarian Neoplasms 26485143 "10 miRNAs (miR-193a-5p, miR-375, miR-339-3p, miR-340-5p, miR-532-3p, miR-133a-3p, miR-25-3p, miR-10a-5p, miR-616-5p, and miR-148b-5p) displayed fold changes in concentration ranging from -2.9 to 4 (p<0.05), in recurrent platinum resistant ovarian cancer patients" -circulation_biomarker_diagnosis_ns hsa-mir-139 Behcet Disease 26486198 miR199-3p and miR720 deserve further confirmation as biomarkers of BD in larger studies. PBMCs from active BD displayed a unique signature of microRNAs which may be implicated in regulation of innate immunity activation and T-cell function. -circulation_biomarker_diagnosis_ns hsa-mir-720 Behcet Disease 26486198 miR199-3p and miR720 deserve further confirmation as biomarkers of BD in larger studies. PBMCs from active BD displayed a unique signature of microRNAs which may be implicated in regulation of innate immunity activation and T-cell function. -circulation_biomarker_diagnosis_ns hsa-mir-143 Bladder Neoplasms 26489968 MiRNAs detected in urine and serum/plasma will demonstrate their potentiality to describe the variegated scenario of BC and to become relevant clinical markers. -circulation_biomarker_diagnosis_ns hsa-mir-92a Bladder Neoplasms 26489968 MiRNAs detected in urine and serum/plasma will demonstrate their potentiality to describe the variegated scenario of BC and to become relevant clinical markers. -circulation_biomarker_diagnosis_ns hsa-mir-126 Diabetes Mellitus 26498351 MiR-21-5p and miR-126a-3p levels in plasma and circulating angiogenic cells:relationship with type 2 diabetes complications. -circulation_biomarker_diagnosis_ns hsa-mir-21 Diabetes Mellitus 26498351 MiR-21-5p and miR-126a-3p levels in plasma and circulating angiogenic cells:relationship with type 2 diabetes complications. -circulation_biomarker_diagnosis_ns hsa-mir-1 Heart Failure 26498537 Dysregulation of miR-1 and miR-21 expression may be essential for the development of HF; miR-1 might become a biomarker for predicting HF exacerbation. -circulation_biomarker_diagnosis_ns hsa-mir-208a Heart Failure 26498537 Dysregulation of miR-1 and miR-21 expression may be essential for the development of HF; miR-1 might become a biomarker for predicting HF exacerbation. -circulation_biomarker_diagnosis_ns hsa-mir-21 Heart Failure 26498537 Dysregulation of miR-1 and miR-21 expression may be essential for the development of HF; miR-1 might become a biomarker for predicting HF exacerbation. -circulation_biomarker_diagnosis_ns hsa-mir-744 Pancreatic Neoplasms 26505678 "Plasma miR-744 might be useful biomarker for screening PCa,monitoring, and predicting poor prognosis and chemoresistance in PCa patients." -circulation_biomarker_diagnosis_ns hsa-mir-494 "Carcinoma, Hepatocellular" 26509672 "Therefore, we show that circulating microRNAs deserve attention as non-invasive biomarkers in the diagnostic setting of HCC and that exosomal secretion contributes to discharging a subset of microRNAs into the extracellular compartment." -circulation_biomarker_diagnosis_ns hsa-mir-519d "Carcinoma, Hepatocellular" 26509672 "Therefore, we show that circulating microRNAs deserve attention as non-invasive biomarkers in the diagnostic setting of HCC and that exosomal secretion contributes to discharging a subset of microRNAs into the extracellular compartment." -circulation_biomarker_diagnosis_ns hsa-mir-595 "Carcinoma, Hepatocellular" 26509672 "Therefore, we show that circulating microRNAs deserve attention as non-invasive biomarkers in the diagnostic setting of HCC and that exosomal secretion contributes to discharging a subset of microRNAs into the extracellular compartment." -circulation_biomarker_diagnosis_ns hsa-mir-939 "Carcinoma, Hepatocellular" 26509672 "Therefore, we show that circulating microRNAs deserve attention as non-invasive biomarkers in the diagnostic setting of HCC and that exosomal secretion contributes to discharging a subset of microRNAs into the extracellular compartment." -circulation_biomarker_diagnosis_ns hsa-mir-21 Gastric Neoplasms 26509997 "In summary, we verified the diagnostic and prognostic value of tissue hsa-miR-21hsa-miR-21 and hsa-miR-29 in GC. Both of them can be potentially applied as novel and non-invasive biomarkers for GC." -circulation_biomarker_diagnosis_ns hsa-mir-29 Gastric Neoplasms 26509997 "In summary, we verified the diagnostic and prognostic value of tissue hsa-miR-21hsa-miR-21 and hsa-miR-29 in GC. Both of them can be potentially applied as novel and non-invasive biomarkers for GC." -circulation_biomarker_diagnosis_ns hsa-mir-126 Angiosarcoma 26512652 "Our findings suggest that these malignant endothelial proliferative diseases over-secreted miR-214 and miR-126, thus suggesting that these miRNAs have potential as diagnostic biomarkers for malignant endothelial proliferative diseases in canine and possible in human angiosarcoma." -circulation_biomarker_diagnosis_ns hsa-mir-214 Angiosarcoma 26512652 "Our findings suggest that these malignant endothelial proliferative diseases over-secreted miR-214 and miR-126, thus suggesting that these miRNAs have potential as diagnostic biomarkers for malignant endothelial proliferative diseases in canine and possible in human angiosarcoma." -circulation_biomarker_diagnosis_ns hsa-mir-15a Multiple Myeloma 26516702 "Therefore, our data suggest that the expression patterns of miR-15a/16-1 are different in MM patients, and miR-15a seems to be linked with disease progression and prognosis while miR-16-1 acts as a valuable diagnostic marker." -circulation_biomarker_diagnosis_ns hsa-mir-16-1 Multiple Myeloma 26516702 "Therefore, our data suggest that the expression patterns of miR-15a/16-1 are different in MM patients, and miR-15a seems to be linked with disease progression and prognosis while miR-16-1 acts as a valuable diagnostic marker." -circulation_biomarker_diagnosis_ns hsa-mir-10b Neoplasms [unspecific] 26522916 Heterogeneity of miR-10b expression in circulating tumor cells. -circulation_biomarker_diagnosis_ns hsa-mir-1 Acute Myocardial Infarction 26526403 "In summary, we confirmed the predictive values of plasma miR-1,miR-208 and miR-499 in AMI. In contrast to miR-1, the cardiac-specific miR-208 and miR-499 were supposed to be more reliable as biomarkers in AMI screening and prediction." -circulation_biomarker_diagnosis_ns hsa-mir-208 Acute Myocardial Infarction 26526403 "In summary, we confirmed the predictive values of plasma miR-1,miR-208 and miR-499 in AMI. In contrast to miR-1, the cardiac-specific miR-208 and miR-499 were supposed to be more reliable as biomarkers in AMI screening and prediction." -circulation_biomarker_diagnosis_ns hsa-mir-499 Acute Myocardial Infarction 26526403 "In summary, we confirmed the predictive values of plasma miR-1,miR-208 and miR-499 in AMI. In contrast to miR-1, the cardiac-specific miR-208 and miR-499 were supposed to be more reliable as biomarkers in AMI screening and prediction." -circulation_biomarker_diagnosis_ns hsa-mir-1183 Rheumatic Heart Diseases 26539505 Detection of Differentially Expressed MicroRNAs in Rheumatic Heart Disease:miR-1183 and miR-1299 as Potential Diagnostic Biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-1299 Rheumatic Heart Diseases 26539505 Detection of Differentially Expressed MicroRNAs in Rheumatic Heart Disease:miR-1183 and miR-1299 as Potential Diagnostic Biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-499 Acute Myocardial Infarction 26547429 "favorable sensitivity and selectivity,thus provides an alternative for the detection of miRNA. Most importantly, this effort may promote miRNA to work as an effective biomarker in the diagnosis of AMI." -circulation_biomarker_diagnosis_ns hsa-mir-10b "Squamous Cell Carcinoma, Esophageal" 26554762 "Predictive Value of Serum miR-10b, miR-29c, and miR-205 as Promising Biomarkers in Esophageal Squamous Cell Carcinoma Screening." -circulation_biomarker_diagnosis_ns hsa-mir-205 "Squamous Cell Carcinoma, Esophageal" 26554762 "Predictive Value of Serum miR-10b, miR-29c, and miR-205 as Promising Biomarkers in Esophageal Squamous Cell Carcinoma Screening." -circulation_biomarker_diagnosis_ns hsa-mir-29c "Squamous Cell Carcinoma, Esophageal" 26554762 "Predictive Value of Serum miR-10b, miR-29c, and miR-205 as Promising Biomarkers in Esophageal Squamous Cell Carcinoma Screening." -circulation_biomarker_diagnosis_ns hsa-mir-320d "Diabetes Mellitus, Type 2" 26554942 This study provided evidence that serum miRNAs had differential expressions between healthy controls and T2DM patients. These five differential expression miRNAs might be of help for subsequent study in T2DM. -circulation_biomarker_diagnosis_ns hsa-mir-3960 "Diabetes Mellitus, Type 2" 26554942 This study provided evidence that serum miRNAs had differential expressions between healthy controls and T2DM patients. These five differential expression miRNAs might be of help for subsequent study in T2DM. -circulation_biomarker_diagnosis_ns hsa-mir-451a "Diabetes Mellitus, Type 2" 26554942 This study provided evidence that serum miRNAs had differential expressions between healthy controls and T2DM patients. These five differential expression miRNAs might be of help for subsequent study in T2DM. -circulation_biomarker_diagnosis_ns hsa-mir-4534 "Diabetes Mellitus, Type 2" 26554942 This study provided evidence that serum miRNAs had differential expressions between healthy controls and T2DM patients. These five differential expression miRNAs might be of help for subsequent study in T2DM. -circulation_biomarker_diagnosis_ns hsa-mir-572 "Diabetes Mellitus, Type 2" 26554942 This study provided evidence that serum miRNAs had differential expressions between healthy controls and T2DM patients. These five differential expression miRNAs might be of help for subsequent study in T2DM. -circulation_biomarker_diagnosis_ns hsa-mir-146b "Colitis, Ulcerative" 26569605 "This is the first study to show the differential expression of miRNA involving different sites of colon in UC patients. Taking our data and previous reports into consideration, we propose that differential miRNA expression during UC perhaps contribute in the development of UC-associated CRC at the rectosigmoid area." -circulation_biomarker_diagnosis_ns hsa-mir-335 "Colitis, Ulcerative" 26569605 "This is the first study to show the differential expression of miRNA involving different sites of colon in UC patients. Taking our data and previous reports into consideration, we propose that differential miRNA expression during UC perhaps contribute in the development of UC-associated CRC at the rectosigmoid area." -circulation_biomarker_diagnosis_ns hsa-mir-342 "Colitis, Ulcerative" 26569605 "This is the first study to show the differential expression of miRNA involving different sites of colon in UC patients. Taking our data and previous reports into consideration, we propose that differential miRNA expression during UC perhaps contribute in the development of UC-associated CRC at the rectosigmoid area." -circulation_biomarker_diagnosis_ns hsa-mir-4732 "Colitis, Ulcerative" 26569605 "This is the first study to show the differential expression of miRNA involving different sites of colon in UC patients. Taking our data and previous reports into consideration, we propose that differential miRNA expression during UC perhaps contribute in the development of UC-associated CRC at the rectosigmoid area." -circulation_biomarker_diagnosis_ns hsa-mir-491 "Colitis, Ulcerative" 26569605 "This is the first study to show the differential expression of miRNA involving different sites of colon in UC patients. Taking our data and previous reports into consideration, we propose that differential miRNA expression during UC perhaps contribute in the development of UC-associated CRC at the rectosigmoid area." -circulation_biomarker_diagnosis_ns hsa-mir-644b "Colitis, Ulcerative" 26569605 "This is the first study to show the differential expression of miRNA involving different sites of colon in UC patients. Taking our data and previous reports into consideration, we propose that differential miRNA expression during UC perhaps contribute in the development of UC-associated CRC at the rectosigmoid area." -circulation_biomarker_diagnosis_ns hsa-mir-140 Gastric Neoplasms 26607322 "This study revealed a three-miRNA signature as a promising classifier for gastric cancer, and greatly enhances the feasibility of circulating miRNAs as non-invasive diagnostic marker for this disease." -circulation_biomarker_diagnosis_ns hsa-mir-18a Gastric Neoplasms 26607322 "This study revealed a three-miRNA signature as a promising classifier for gastric cancer, and greatly enhances the feasibility of circulating miRNAs as non-invasive diagnostic marker for this disease." -circulation_biomarker_diagnosis_ns hsa-mir-199a Gastric Neoplasms 26607322 "This study revealed a three-miRNA signature as a promising classifier for gastric cancer, and greatly enhances the feasibility of circulating miRNAs as non-invasive diagnostic marker for this disease." -circulation_biomarker_diagnosis_ns hsa-mir-627 Gastric Neoplasms 26607322 "This study revealed a three-miRNA signature as a promising classifier for gastric cancer, and greatly enhances the feasibility of circulating miRNAs as non-invasive diagnostic marker for this disease." -circulation_biomarker_diagnosis_ns hsa-mir-629 Gastric Neoplasms 26607322 "This study revealed a three-miRNA signature as a promising classifier for gastric cancer, and greatly enhances the feasibility of circulating miRNAs as non-invasive diagnostic marker for this disease." -circulation_biomarker_diagnosis_ns hsa-mir-652 Gastric Neoplasms 26607322 "This study revealed a three-miRNA signature as a promising classifier for gastric cancer, and greatly enhances the feasibility of circulating miRNAs as non-invasive diagnostic marker for this disease." -circulation_biomarker_diagnosis_ns hsa-mir-29b Glioma 26620922 miR-29b and VEGFA in blood were significantly different compared with the control group -circulation_biomarker_diagnosis_ns hsa-mir-193a "Carcinoma, Lung, Non-Small-Cell" 26629532 This serum miRNA panel holds the potential for diagnosing ethnically diverse NSCLC patients -circulation_biomarker_diagnosis_ns hsa-mir-214 "Carcinoma, Lung, Non-Small-Cell" 26629532 This serum miRNA panel holds the potential for diagnosing ethnically diverse NSCLC patients -circulation_biomarker_diagnosis_ns hsa-mir-25 "Carcinoma, Lung, Non-Small-Cell" 26629532 This serum miRNA panel holds the potential for diagnosing ethnically diverse NSCLC patients -circulation_biomarker_diagnosis_ns hsa-mir-483 "Carcinoma, Lung, Non-Small-Cell" 26629532 This serum miRNA panel holds the potential for diagnosing ethnically diverse NSCLC patients -circulation_biomarker_diagnosis_ns hsa-mir-7 "Carcinoma, Lung, Non-Small-Cell" 26629532 This serum miRNA panel holds the potential for diagnosing ethnically diverse NSCLC patients -circulation_biomarker_diagnosis_ns hsa-mir-125b "Carcinoma, Hepatocellular" 26637228 "A combination of serum miR-125b, miR-223, miR-27a, and miR-26a as a second-line tests could help detect HCC in AFP (-) subjects." -circulation_biomarker_diagnosis_ns hsa-mir-122 Rheumatoid Arthritis 26637811 "In conclusion, this study identified 9-plasma miRNAs signature in Chinese patients with RA which may serve as noninvasive biomarkers for the diagnosis of RA." -circulation_biomarker_diagnosis_ns hsa-mir-219-2 Rheumatoid Arthritis 26637811 "In conclusion, this study identified 9-plasma miRNAs signature in Chinese patients with RA which may serve as noninvasive biomarkers for the diagnosis of RA." -circulation_biomarker_diagnosis_ns hsa-mir-342 Rheumatoid Arthritis 26637811 "In conclusion, this study identified 9-plasma miRNAs signature in Chinese patients with RA which may serve as noninvasive biomarkers for the diagnosis of RA." -circulation_biomarker_diagnosis_ns hsa-mir-3925 Rheumatoid Arthritis 26637811 "In conclusion, this study identified 9-plasma miRNAs signature in Chinese patients with RA which may serve as noninvasive biomarkers for the diagnosis of RA." -circulation_biomarker_diagnosis_ns hsa-mir-3926 Rheumatoid Arthritis 26637811 "In conclusion, this study identified 9-plasma miRNAs signature in Chinese patients with RA which may serve as noninvasive biomarkers for the diagnosis of RA." -circulation_biomarker_diagnosis_ns hsa-mir-4634 Rheumatoid Arthritis 26637811 "In conclusion, this study identified 9-plasma miRNAs signature in Chinese patients with RA which may serve as noninvasive biomarkers for the diagnosis of RA." -circulation_biomarker_diagnosis_ns hsa-mir-4764 Rheumatoid Arthritis 26637811 "In conclusion, this study identified 9-plasma miRNAs signature in Chinese patients with RA which may serve as noninvasive biomarkers for the diagnosis of RA." -circulation_biomarker_diagnosis_ns hsa-mir-9 Rheumatoid Arthritis 26637811 "In conclusion, this study identified 9-plasma miRNAs signature in Chinese patients with RA which may serve as noninvasive biomarkers for the diagnosis of RA." -circulation_biomarker_diagnosis_ns hsa-mir-16-2 "Carcinoma, Cervical" 26656154 "Serum miRNAs panel (miR-16-2*, miR-195, miR-2861, miR-497) as novel non-invasive biomarkers for detection of cervical cancer." -circulation_biomarker_diagnosis_ns hsa-mir-195 "Carcinoma, Cervical" 26656154 "Serum miRNAs panel (miR-16-2*, miR-195, miR-2861, miR-497) as novel non-invasive biomarkers for detection of cervical cancer." -circulation_biomarker_diagnosis_ns hsa-mir-2861 "Carcinoma, Cervical" 26656154 "Serum miRNAs panel (miR-16-2*, miR-195, miR-2861, miR-497) as novel non-invasive biomarkers for detection of cervical cancer." -circulation_biomarker_diagnosis_ns hsa-mir-497 "Carcinoma, Cervical" 26656154 "Serum miRNAs panel (miR-16-2*, miR-195, miR-2861, miR-497) as novel non-invasive biomarkers for detection of cervical cancer." -circulation_biomarker_diagnosis_ns hsa-mir-34 Ewing Sarcoma 26659003 MicroRNA expression profiling may have some potential for prediction of disease progression and survival in Ewing sarcoma. -circulation_biomarker_diagnosis_ns hsa-mir-367 Germ Cell Tumor 26671749 A pipeline to quantify serum and cerebrospinal fluid microRNAs for diagnosis and detection of relapse in paediatric malignant germ-cell tumours. -circulation_biomarker_diagnosis_ns hsa-mir-371a Germ Cell Tumor 26671749 A pipeline to quantify serum and cerebrospinal fluid microRNAs for diagnosis and detection of relapse in paediatric malignant germ-cell tumours. -circulation_biomarker_diagnosis_ns hsa-mir-372 Germ Cell Tumor 26671749 A pipeline to quantify serum and cerebrospinal fluid microRNAs for diagnosis and detection of relapse in paediatric malignant germ-cell tumours. -circulation_biomarker_diagnosis_ns hsa-mir-373 Germ Cell Tumor 26671749 A pipeline to quantify serum and cerebrospinal fluid microRNAs for diagnosis and detection of relapse in paediatric malignant germ-cell tumours. -circulation_biomarker_diagnosis_ns hsa-mir-20a "Carcinoma, Lung, Non-Small-Cell" 26672767 "Among the top markers that were concordant between both studies we found hsa-miR-20b-5p, hsa-miR-20a-5p, hsa-miR-17-5p, and hsa-miR-106a-5p." -circulation_biomarker_diagnosis_ns hsa-mir-31 "Tuberculosis, Pulmonary" 26681217 "Therefore, miR-31 has the potential to be a diagnostic marker in pediatric TB patients." -circulation_biomarker_diagnosis_ns hsa-mir-21 Digestive System Neoplasms 26683919 Potential Role of Circulating MiR-21 in the Diagnosis and Prognosis of Digestive System Cancer: A Systematic Review and Meta-Analysis. -circulation_biomarker_diagnosis_ns hsa-mir-16 Spondylarthritis 26689798 The most repressed miRNA was miR-16 and is predicted to regulate the expression of activin A receptor -circulation_biomarker_diagnosis_ns hsa-mir-21 Gastric Neoplasms 26720919 Two-stage cyclic enzymatic amplification method for ultrasensitive electrochemical assay of microRNA-21 in the blood serum of gastric cancer patients. -circulation_biomarker_diagnosis_ns hsa-mir-1246 Breast Neoplasms 26749252 Novel combination of serum microRNA for detecting breast cancer in the early stage. -circulation_biomarker_diagnosis_ns hsa-mir-1307 Breast Neoplasms 26749252 Novel combination of serum microRNA for detecting breast cancer in the early stage. -circulation_biomarker_diagnosis_ns hsa-mir-4634 Breast Neoplasms 26749252 Novel combination of serum microRNA for detecting breast cancer in the early stage. -circulation_biomarker_diagnosis_ns hsa-mir-6861 Breast Neoplasms 26749252 Novel combination of serum microRNA for detecting breast cancer in the early stage. -circulation_biomarker_diagnosis_ns hsa-mir-6875 Breast Neoplasms 26749252 Novel combination of serum microRNA for detecting breast cancer in the early stage. -circulation_biomarker_diagnosis_ns hsa-mir-126 "Carcinoma, Hepatocellular" 26756996 Hepatic miR-126 is a potential plasma biomarker for detection of hepatitis B virus infected hepatocellular carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-155 Neoplasms [unspecific] 26765436 Appraising MicroRNA-155 as a Noninvasive Diagnostic Biomarker for Cancer Detection: A Meta-Analysis. -circulation_biomarker_diagnosis_ns hsa-mir-223 "Carcinoma, Hepatocellular" 26776075 Serum miR-30e and miR-224 as Novel Noninvasive Biomarkers for Hepatocellular Carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-30e "Carcinoma, Hepatocellular" 26776075 Serum miR-30e and miR-223 as Novel Noninvasive Biomarkers for Hepatocellular Carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-196a "Carcinoma, Cervical" 26782446 Clinical significance of serum miR-196a in cervical intraepithelial neoplasia and cervical cancer. -circulation_biomarker_diagnosis_ns hsa-mir-132 Stroke 26806865 "These results indicated that there was a substantial correlation between serum miR-132 expression and post-stroke cognitive functionality,suggesting that miR-132 may be a risk marker for PSCI. Because of the limitations of this study, the results should be treated with caution. cel-mir-39" -circulation_biomarker_diagnosis_ns hsa-mir-204 Pancreatic Adenocarcinoma 26807325 miR-223 and miR-204 were able to distinguish patients with early stage cancer from patients with CP -circulation_biomarker_diagnosis_ns hsa-mir-34b Major Depressive Disorder 26807671 "Differentially Notch-associated miRNAs expressions in peripheral blood might be involved in MDD, and the miR-34b-5p and miR-34c-5p levels in peripheral blood leukocytes are closely related to MDD, suicide idea and cognitive function, further studies with large sample size are warranted to test the feasibility of these miRNAs serving as biomarkers for MDD." -circulation_biomarker_diagnosis_ns hsa-mir-34c Major Depressive Disorder 26807671 "Differentially Notch-associated miRNAs expressions in peripheral blood might be involved in MDD, and the miR-34b-5p and miR-34c-5p levels in peripheral blood leukocytes are closely related to MDD, suicide idea and cognitive function, further studies with large sample size are warranted to test the feasibility of these miRNAs serving as biomarkers for MDD." -circulation_biomarker_diagnosis_ns hsa-mir-3663 Inherited Hemoglobin Disease 26837891 "Discussion Five of these microRNAs including U101, hsa-miR-4726-5p, hsa-miR7109 5p, hsa-miR3663, and hsa-miR940 had significant changes in expression and volume." -circulation_biomarker_diagnosis_ns hsa-mir-4726 Inherited Hemoglobin Disease 26837891 "Discussion Five of these microRNAs including U101, hsa-miR-4726-5p, hsa-miR7109 5p, hsa-miR3663, and hsa-miR940 had significant changes in expression and volume." -circulation_biomarker_diagnosis_ns hsa-mir-7109 Inherited Hemoglobin Disease 26837891 "Discussion Five of these microRNAs including U101, hsa-miR-4726-5p, hsa-miR7109 5p, hsa-miR3663, and hsa-miR940 had significant changes in expression and volume." -circulation_biomarker_diagnosis_ns hsa-mir-940 Inherited Hemoglobin Disease 26837891 "Discussion Five of these microRNAs including U101, hsa-miR-4726-5p, hsa-miR7109 5p, hsa-miR3663, and hsa-miR940 had significant changes in expression and volume." -circulation_biomarker_diagnosis_ns hsa-mir-200c Cholangiocarcinoma 26864161 miR-200c was found to be expressed differentially in PSC versus controls -circulation_biomarker_diagnosis_ns hsa-mir-222 Cholangiocarcinoma 26864161 a difference in the expression of miR-222 and miR-483-5p in CC versus PSC -circulation_biomarker_diagnosis_ns hsa-mir-21 Acute Myocardial Infarction 26875904 Plasma miR-21 may be a novel biomarker for the diagnosis of AMI. Our study may also provide implications for the development of new biomarkers. -circulation_biomarker_diagnosis_ns hsa-mir-132 Alzheimer Disease 26899870 Dysregulation of miRNA isoform level at 5' end in Alzheimer's disease. -circulation_biomarker_diagnosis_ns hsa-mir-136 Alzheimer Disease 26899870 Dysregulation of miRNA isoform level at 5' end in Alzheimer's disease. -circulation_biomarker_diagnosis_ns hsa-mir-137 Alzheimer Disease 26899870 Dysregulation of miRNA isoform level at 5' end in Alzheimer's disease. -circulation_biomarker_diagnosis_ns hsa-mir-103 Myotonic Dystrophy Type 1 26919350 "a selection of six candidate miRNAs, miR-103, miR-107, miR-21, miR-29a, miR-30c, and miR-652 all failed to show consistent differences in serum expression in subsequent validation experiments." -circulation_biomarker_diagnosis_ns hsa-mir-107 Myotonic Dystrophy Type 1 26919350 "a selection of six candidate miRNAs, miR-103, miR-107, miR-21, miR-29a, miR-30c, and miR-652 all failed to show consistent differences in serum expression in subsequent validation experiments." -circulation_biomarker_diagnosis_ns hsa-mir-107 Hirschsprung Disease 26933947 miRNA Profiling Reveals Dysregulation of RET and RET-Regulating Pathways in Hirschsprung's Disease. -circulation_biomarker_diagnosis_ns hsa-mir-142 Hirschsprung Disease 26933947 miRNA Profiling Reveals Dysregulation of RET and RET-Regulating Pathways in Hirschsprung's Disease. -circulation_biomarker_diagnosis_ns hsa-mir-146b Hirschsprung Disease 26933947 miRNA Profiling Reveals Dysregulation of RET and RET-Regulating Pathways in Hirschsprung's Disease. -circulation_biomarker_diagnosis_ns hsa-mir-369 Hirschsprung Disease 26933947 miRNA Profiling Reveals Dysregulation of RET and RET-Regulating Pathways in Hirschsprung's Disease. -circulation_biomarker_diagnosis_ns hsa-mir-429 Hirschsprung Disease 26933947 miRNA Profiling Reveals Dysregulation of RET and RET-Regulating Pathways in Hirschsprung's Disease. -circulation_biomarker_diagnosis_ns hsa-mir-638 Hirschsprung Disease 26933947 miRNA Profiling Reveals Dysregulation of RET and RET-Regulating Pathways in Hirschsprung's Disease. -circulation_biomarker_diagnosis_ns hsa-mir-885 Hirschsprung Disease 26933947 miRNA Profiling Reveals Dysregulation of RET and RET-Regulating Pathways in Hirschsprung's Disease. -circulation_biomarker_diagnosis_ns hsa-mir-938 Hirschsprung Disease 26933947 miRNA Profiling Reveals Dysregulation of RET and RET-Regulating Pathways in Hirschsprung's Disease. -circulation_biomarker_diagnosis_ns hsa-mir-133a Hypertension 26984682 miRNA-208b and miRNA-133a show distinct profiling in peripheral blood cells isolated from untreated patients -circulation_biomarker_diagnosis_ns hsa-mir-208b Hypertension 26984682 miRNA-208b and miRNA-133a show distinct profiling in peripheral blood cells isolated from untreated patients -circulation_biomarker_diagnosis_ns hsa-mir-26a Gastric Neoplasms 27010210 Circulating MicroRNA-26a in Plasma and Its Potential Diagnostic Value in Gastric Cancer. -circulation_biomarker_diagnosis_ns hsa-mir-146a Autoimmune Lymphoproliferative Syndrome 27060458 "miR-21-3p was over-expressed significantly (P = 0·0313) in the son, with no significant change in the expression of miR-146a, miR-146a-3p and miR-21." -circulation_biomarker_diagnosis_ns hsa-mir-130a "Carcinoma, Ovarian" 27062783 Expression of MiR-130a in Serum Samples of Patients with Epithelial Ovarian Cancer and Its Association with Platinum Resistance. -circulation_biomarker_diagnosis_ns hsa-mir-144 Glaucoma 27064390 "Our data illustrate the feasibility of miRNA analysis by NGS in small individual aqueous humor samples. Intraocular cells as well as blood plasma contribute to the extracellular aqueous humor miRNome. The data suggest possible roles of miRNA in intraocular cell adhesion and signaling by TGF-¦Â and Wnt, which are important in intraocular pressure regulation and glaucoma." -circulation_biomarker_diagnosis_ns hsa-mir-16 Glaucoma 27064390 "Our data illustrate the feasibility of miRNA analysis by NGS in small individual aqueous humor samples. Intraocular cells as well as blood plasma contribute to the extracellular aqueous humor miRNome. The data suggest possible roles of miRNA in intraocular cell adhesion and signaling by TGF-¦Â and Wnt, which are important in intraocular pressure regulation and glaucoma." -circulation_biomarker_diagnosis_ns hsa-mir-184 Glaucoma 27064390 "Our data illustrate the feasibility of miRNA analysis by NGS in small individual aqueous humor samples. Intraocular cells as well as blood plasma contribute to the extracellular aqueous humor miRNome. The data suggest possible roles of miRNA in intraocular cell adhesion and signaling by TGF-¦Â and Wnt, which are important in intraocular pressure regulation and glaucoma." -circulation_biomarker_diagnosis_ns hsa-mir-19a Glaucoma 27064390 "Our data illustrate the feasibility of miRNA analysis by NGS in small individual aqueous humor samples. Intraocular cells as well as blood plasma contribute to the extracellular aqueous humor miRNome. The data suggest possible roles of miRNA in intraocular cell adhesion and signaling by TGF-¦Â and Wnt, which are important in intraocular pressure regulation and glaucoma." -circulation_biomarker_diagnosis_ns hsa-mir-202 Glaucoma 27064390 "Our data illustrate the feasibility of miRNA analysis by NGS in small individual aqueous humor samples. Intraocular cells as well as blood plasma contribute to the extracellular aqueous humor miRNome. The data suggest possible roles of miRNA in intraocular cell adhesion and signaling by TGF-¦Â and Wnt, which are important in intraocular pressure regulation and glaucoma." -circulation_biomarker_diagnosis_ns hsa-mir-205 Glaucoma 27064390 "Our data illustrate the feasibility of miRNA analysis by NGS in small individual aqueous humor samples. Intraocular cells as well as blood plasma contribute to the extracellular aqueous humor miRNome. The data suggest possible roles of miRNA in intraocular cell adhesion and signaling by TGF-¦Â and Wnt, which are important in intraocular pressure regulation and glaucoma." -circulation_biomarker_diagnosis_ns hsa-mir-22 Glaucoma 27064390 "Our data illustrate the feasibility of miRNA analysis by NGS in small individual aqueous humor samples. Intraocular cells as well as blood plasma contribute to the extracellular aqueous humor miRNome. The data suggest possible roles of miRNA in intraocular cell adhesion and signaling by TGF-¦Â and Wnt, which are important in intraocular pressure regulation and glaucoma." -circulation_biomarker_diagnosis_ns hsa-mir-24 Glaucoma 27064390 "Our data illustrate the feasibility of miRNA analysis by NGS in small individual aqueous humor samples. Intraocular cells as well as blood plasma contribute to the extracellular aqueous humor miRNome. The data suggest possible roles of miRNA in intraocular cell adhesion and signaling by TGF-¦Â and Wnt, which are important in intraocular pressure regulation and glaucoma." -circulation_biomarker_diagnosis_ns hsa-mir-29a Glaucoma 27064390 "Our data illustrate the feasibility of miRNA analysis by NGS in small individual aqueous humor samples. Intraocular cells as well as blood plasma contribute to the extracellular aqueous humor miRNome. The data suggest possible roles of miRNA in intraocular cell adhesion and signaling by TGF-¦Â and Wnt, which are important in intraocular pressure regulation and glaucoma." -circulation_biomarker_diagnosis_ns hsa-mir-29c Glaucoma 27064390 "Our data illustrate the feasibility of miRNA analysis by NGS in small individual aqueous humor samples. Intraocular cells as well as blood plasma contribute to the extracellular aqueous humor miRNome. The data suggest possible roles of miRNA in intraocular cell adhesion and signaling by TGF-¦Â and Wnt, which are important in intraocular pressure regulation and glaucoma." -circulation_biomarker_diagnosis_ns hsa-mir-3074 Glaucoma 27064390 "Our data illustrate the feasibility of miRNA analysis by NGS in small individual aqueous humor samples. Intraocular cells as well as blood plasma contribute to the extracellular aqueous humor miRNome. The data suggest possible roles of miRNA in intraocular cell adhesion and signaling by TGF-¦Â and Wnt, which are important in intraocular pressure regulation and glaucoma." -circulation_biomarker_diagnosis_ns hsa-mir-30a Glaucoma 27064390 "Our data illustrate the feasibility of miRNA analysis by NGS in small individual aqueous humor samples. Intraocular cells as well as blood plasma contribute to the extracellular aqueous humor miRNome. The data suggest possible roles of miRNA in intraocular cell adhesion and signaling by TGF-¦Â and Wnt, which are important in intraocular pressure regulation and glaucoma." -circulation_biomarker_diagnosis_ns hsa-mir-30d Glaucoma 27064390 "Our data illustrate the feasibility of miRNA analysis by NGS in small individual aqueous humor samples. Intraocular cells as well as blood plasma contribute to the extracellular aqueous humor miRNome. The data suggest possible roles of miRNA in intraocular cell adhesion and signaling by TGF-¦Â and Wnt, which are important in intraocular pressure regulation and glaucoma." -circulation_biomarker_diagnosis_ns hsa-mir-4448 Glaucoma 27064390 "Our data illustrate the feasibility of miRNA analysis by NGS in small individual aqueous humor samples. Intraocular cells as well as blood plasma contribute to the extracellular aqueous humor miRNome. The data suggest possible roles of miRNA in intraocular cell adhesion and signaling by TGF-¦Â and Wnt, which are important in intraocular pressure regulation and glaucoma." -circulation_biomarker_diagnosis_ns hsa-mir-451a Glaucoma 27064390 "Our data illustrate the feasibility of miRNA analysis by NGS in small individual aqueous humor samples. Intraocular cells as well as blood plasma contribute to the extracellular aqueous humor miRNome. The data suggest possible roles of miRNA in intraocular cell adhesion and signaling by TGF-¦Â and Wnt, which are important in intraocular pressure regulation and glaucoma." -circulation_biomarker_diagnosis_ns hsa-mir-122 "Fatty Liver, Non-Alcoholic" 27077736 Association of Circulating Serum miR-34a and miR-122 with Dyslipidemia among Patients with Non-Alcoholic Fatty Liver Disease. -circulation_biomarker_diagnosis_ns hsa-mir-34a "Fatty Liver, Non-Alcoholic" 27077736 Association of Circulating Serum miR-34a and miR-122 with Dyslipidemia among Patients with Non-Alcoholic Fatty Liver Disease. -circulation_biomarker_diagnosis_ns hsa-mir-125b "Carcinoma, Ovarian" 27092777 Utility of Serum miR-125b as a Diagnostic and Prognostic Indicator and Its Alliance with a Panel of Tumor Suppressor Genes in Epithelial Ovarian Cancer. -circulation_biomarker_diagnosis_ns hsa-mir-126 Early-Stage Non-Small-Cell Lung Carcinoma 27093275 "Diagnostic Value of Serum miR-182, miR-183, miR-210, and miR-126 Levels in Patients with Early-Stage Non-Small Cell Lung Cancer." -circulation_biomarker_diagnosis_ns hsa-mir-182 Early-Stage Non-Small-Cell Lung Carcinoma 27093275 "Diagnostic Value of Serum miR-182, miR-183, miR-210, and miR-126 Levels in Patients with Early-Stage Non-Small Cell Lung Cancer." -circulation_biomarker_diagnosis_ns hsa-mir-183 Early-Stage Non-Small-Cell Lung Carcinoma 27093275 "Diagnostic Value of Serum miR-182, miR-183, miR-210, and miR-126 Levels in Patients with Early-Stage Non-Small Cell Lung Cancer." -circulation_biomarker_diagnosis_ns hsa-mir-210 Early-Stage Non-Small-Cell Lung Carcinoma 27093275 "Diagnostic Value of Serum miR-182, miR-183, miR-210, and miR-126 Levels in Patients with Early-Stage Non-Small Cell Lung Cancer." -circulation_biomarker_diagnosis_ns hsa-mir-372 "Carcinoma, Lung, Non-Small-Cell" 27122989 "A sputum mir-21, mir-210, and mir-372 expression profile might provide a sensitive and highly specific means for detecting nsclc." -circulation_biomarker_diagnosis_ns hsa-mir-122 "Stroke, Ischemic" 27151415 Two miRNAs (miR-145 and miR-122) may represent potential biomarkers in ischemic stroke -circulation_biomarker_diagnosis_ns hsa-let-7g Myocardial Infarction 27192016 we identified several miRs associated with future AMI -circulation_biomarker_diagnosis_ns hsa-mir-106a Myocardial Infarction 27192016 we identified several miRs associated with future AMI -circulation_biomarker_diagnosis_ns hsa-mir-144 Myocardial Infarction 27192016 we identified several miRs associated with future AMI -circulation_biomarker_diagnosis_ns hsa-mir-26a Myocardial Infarction 27192016 miR-424-5p and miR-26a-5p were associated exclusively with risk in men and women -circulation_biomarker_diagnosis_ns hsa-mir-424 Myocardial Infarction 27192016 we identified several miRs associated with future AMI -circulation_biomarker_diagnosis_ns hsa-mir-660 Myocardial Infarction 27192016 we identified several miRs associated with future AMI -circulation_biomarker_diagnosis_ns hsa-mir-122 Hepatitis C Virus Infection 27239848 Evaluation of miR-122 level in the plasma of chronically HCV infected patients. -circulation_biomarker_diagnosis_ns hsa-mir-122 Idiopathic Asthenospermia 27264812 Seminal plasma miR-122-3p and miR-141-5p stability and its diagnosis value for idiopathic asthenospermia. -circulation_biomarker_diagnosis_ns hsa-mir-141 Idiopathic Asthenospermia 27264812 Seminal plasma miR-122-3p and miR-141-5p stability and its diagnosis value for idiopathic asthenospermia. -circulation_biomarker_diagnosis_ns hsa-mir-122 "Carcinoma, Hepatocellular" 27271989 "Using miRNA panel of miR-122, miR-885-5p, and miR-29b with alpha fetoprotein (AFP) provided high diagnostic accuracy" -circulation_biomarker_diagnosis_ns hsa-mir-199a "Carcinoma, Hepatocellular" 27271989 using miRNA panel of miR-22 and miR-199a-3p with AFP provided high diagnostic accuracy -circulation_biomarker_diagnosis_ns hsa-mir-22 "Carcinoma, Hepatocellular" 27271989 using miRNA panel of miR-22 and miR-199a-3p with AFP provided high diagnostic accuracy -circulation_biomarker_diagnosis_ns hsa-mir-221 "Carcinoma, Hepatocellular" 27271989 "using miRNA panel of miR-122, miR-885-5p, miR-221, and miR-22 with AFP provided high diagnostic accuracy" -circulation_biomarker_diagnosis_ns hsa-mir-29b "Carcinoma, Hepatocellular" 27271989 "Using miRNA panel of miR-122, miR-885-5p, and miR-29b with alpha fetoprotein (AFP) provided high diagnostic accuracy" -circulation_biomarker_diagnosis_ns hsa-mir-885 "Carcinoma, Hepatocellular" 27271989 "Using miRNA panel of miR-122, miR-885-5p, and miR-29b with alpha fetoprotein (AFP) provided high diagnostic accuracy" -circulation_biomarker_diagnosis_ns hsa-mir-21 Breast Neoplasms 27311114 MicroRNA-21 (miR-21) is a promising diagnostic biomarker for breast cancer screening and disease progression -circulation_biomarker_diagnosis_ns hsa-mir-132 Spinal Muscular Atrophy 27377135 confirmed a significant alteration of miR-9 and miR-132 level in serum samples from SMA patients. -circulation_biomarker_diagnosis_ns hsa-mir-193b Pancreatic Neoplasms 27380024 "Patients with PDAC or IPMN showed significantly higher amounts of serum MAPK-associated miRNAs than those with AIP (p<0.009 for miR-7, p<0.002 for miR-34a, p<0.001 for miR-181d, p<0.002 for miR-193b)." -circulation_biomarker_diagnosis_ns hsa-mir-34a Pancreatic Neoplasms 27380024 "Patients with PDAC or IPMN showed significantly higher amounts of serum MAPK-associated miRNAs than those with AIP (p<0.009 for miR-7, p<0.002 for miR-34a, p<0.001 for miR-181d, p<0.002 for miR-193b)." -circulation_biomarker_diagnosis_ns hsa-mir-7 Pancreatic Neoplasms 27380024 "Patients with PDAC or IPMN showed significantly higher amounts of serum MAPK-associated miRNAs than those with AIP (p<0.009 for miR-7, p<0.002 for miR-34a, p<0.001 for miR-181d, p<0.002 for miR-193b)." -circulation_biomarker_diagnosis_ns hsa-mir-122 Sepsis 27434572 "The researches regarding circulating miRNA as biomarkers of sepsis were collected to analyze the characteristics of differential expression of miRNAs including miR-150, miR-133a, miR-122, miR-223, miR-4772, miR-297 and miR-574-5p etc." -circulation_biomarker_diagnosis_ns hsa-mir-133a Sepsis 27434572 "The researches regarding circulating miRNA as biomarkers of sepsis were collected to analyze the characteristics of differential expression of miRNAs including miR-150, miR-133a, miR-122, miR-223, miR-4772, miR-297 and miR-574-5p etc." -circulation_biomarker_diagnosis_ns hsa-mir-150 Sepsis 27434572 "The researches regarding circulating miRNA as biomarkers of sepsis were collected to analyze the characteristics of differential expression of miRNAs including miR-150, miR-133a, miR-122, miR-223, miR-4772, miR-297 and miR-574-5p etc." -circulation_biomarker_diagnosis_ns hsa-mir-223 Sepsis 27434572 "The researches regarding circulating miRNA as biomarkers of sepsis were collected to analyze the characteristics of differential expression of miRNAs including miR-150, miR-133a, miR-122, miR-223, miR-4772, miR-297 and miR-574-5p etc." -circulation_biomarker_diagnosis_ns hsa-mir-297 Sepsis 27434572 "The researches regarding circulating miRNA as biomarkers of sepsis were collected to analyze the characteristics of differential expression of miRNAs including miR-150, miR-133a, miR-122, miR-223, miR-4772, miR-297 and miR-574-5p etc." -circulation_biomarker_diagnosis_ns hsa-mir-4772 Sepsis 27434572 "The researches regarding circulating miRNA as biomarkers of sepsis were collected to analyze the characteristics of differential expression of miRNAs including miR-150, miR-133a, miR-122, miR-223, miR-4772, miR-297 and miR-574-5p etc." -circulation_biomarker_diagnosis_ns hsa-mir-574 Sepsis 27434572 "The researches regarding circulating miRNA as biomarkers of sepsis were collected to analyze the characteristics of differential expression of miRNAs including miR-150, miR-133a, miR-122, miR-223, miR-4772, miR-297 and miR-574-5p etc." -circulation_biomarker_diagnosis_ns hsa-mir-16 "Carcinoma, Pancreatic" 27464352 "We found that 34 miRNAs in serum from PC patients in the discovery cohort were expressed differently than in controls. These miRNAs were tested in the training cohort, and four diagnostic panels were constructed that included 5 or 12 miRNAs (miR-16, -18a, -20a, -24, -25, -27a, -29c, -30a.5p, -191, -323.3p, -345 and -483.5p)." -circulation_biomarker_diagnosis_ns hsa-mir-18a "Carcinoma, Pancreatic" 27464352 "We found that 34 miRNAs in serum from PC patients in the discovery cohort were expressed differently than in controls. These miRNAs were tested in the training cohort, and four diagnostic panels were constructed that included 5 or 12 miRNAs (miR-16, -18a, -20a, -24, -25, -27a, -29c, -30a.5p, -191, -323.3p, -345 and -483.5p)." -circulation_biomarker_diagnosis_ns hsa-mir-191 "Carcinoma, Pancreatic" 27464352 "We found that 34 miRNAs in serum from PC patients in the discovery cohort were expressed differently than in controls. These miRNAs were tested in the training cohort, and four diagnostic panels were constructed that included 5 or 12 miRNAs (miR-16, -18a, -20a, -24, -25, -27a, -29c, -30a.5p, -191, -323.3p, -345 and -483.5p)." -circulation_biomarker_diagnosis_ns hsa-mir-20a "Carcinoma, Pancreatic" 27464352 "We found that 34 miRNAs in serum from PC patients in the discovery cohort were expressed differently than in controls. These miRNAs were tested in the training cohort, and four diagnostic panels were constructed that included 5 or 12 miRNAs (miR-16, -18a, -20a, -24, -25, -27a, -29c, -30a.5p, -191, -323.3p, -345 and -483.5p)." -circulation_biomarker_diagnosis_ns hsa-mir-24 "Carcinoma, Pancreatic" 27464352 "We found that 34 miRNAs in serum from PC patients in the discovery cohort were expressed differently than in controls. These miRNAs were tested in the training cohort, and four diagnostic panels were constructed that included 5 or 12 miRNAs (miR-16, -18a, -20a, -24, -25, -27a, -29c, -30a.5p, -191, -323.3p, -345 and -483.5p)." -circulation_biomarker_diagnosis_ns hsa-mir-25 "Carcinoma, Pancreatic" 27464352 "We found that 34 miRNAs in serum from PC patients in the discovery cohort were expressed differently than in controls. These miRNAs were tested in the training cohort, and four diagnostic panels were constructed that included 5 or 12 miRNAs (miR-16, -18a, -20a, -24, -25, -27a, -29c, -30a.5p, -191, -323.3p, -345 and -483.5p)." -circulation_biomarker_diagnosis_ns hsa-mir-27a "Carcinoma, Pancreatic" 27464352 "We found that 34 miRNAs in serum from PC patients in the discovery cohort were expressed differently than in controls. These miRNAs were tested in the training cohort, and four diagnostic panels were constructed that included 5 or 12 miRNAs (miR-16, -18a, -20a, -24, -25, -27a, -29c, -30a.5p, -191, -323.3p, -345 and -483.5p)." -circulation_biomarker_diagnosis_ns hsa-mir-29c "Carcinoma, Pancreatic" 27464352 "We found that 34 miRNAs in serum from PC patients in the discovery cohort were expressed differently than in controls. These miRNAs were tested in the training cohort, and four diagnostic panels were constructed that included 5 or 12 miRNAs (miR-16, -18a, -20a, -24, -25, -27a, -29c, -30a.5p, -191, -323.3p, -345 and -483.5p)." -circulation_biomarker_diagnosis_ns hsa-mir-30a "Carcinoma, Pancreatic" 27464352 "We found that 34 miRNAs in serum from PC patients in the discovery cohort were expressed differently than in controls. These miRNAs were tested in the training cohort, and four diagnostic panels were constructed that included 5 or 12 miRNAs (miR-16, -18a, -20a, -24, -25, -27a, -29c, -30a.5p, -191, -323.3p, -345 and -483.5p)." -circulation_biomarker_diagnosis_ns hsa-mir-323 "Carcinoma, Pancreatic" 27464352 "We found that 34 miRNAs in serum from PC patients in the discovery cohort were expressed differently than in controls. These miRNAs were tested in the training cohort, and four diagnostic panels were constructed that included 5 or 12 miRNAs (miR-16, -18a, -20a, -24, -25, -27a, -29c, -30a.5p, -191, -323.3p, -345 and -483.5p)." -circulation_biomarker_diagnosis_ns hsa-mir-345 "Carcinoma, Pancreatic" 27464352 "We found that 34 miRNAs in serum from PC patients in the discovery cohort were expressed differently than in controls. These miRNAs were tested in the training cohort, and four diagnostic panels were constructed that included 5 or 12 miRNAs (miR-16, -18a, -20a, -24, -25, -27a, -29c, -30a.5p, -191, -323.3p, -345 and -483.5p)." -circulation_biomarker_diagnosis_ns hsa-mir-483 "Carcinoma, Pancreatic" 27464352 "We found that 34 miRNAs in serum from PC patients in the discovery cohort were expressed differently than in controls. These miRNAs were tested in the training cohort, and four diagnostic panels were constructed that included 5 or 12 miRNAs (miR-16, -18a, -20a, -24, -25, -27a, -29c, -30a.5p, -191, -323.3p, -345 and -483.5p)." -circulation_biomarker_diagnosis_ns hsa-mir-148b "Carcinoma, Thyroid, Follicular" 27473101 The best two-miRNA classifier (miR-484/miR-148b-3p) identified thyroid malignancy with a sensitivity of 89â€? and a specificity of 87â€?. -circulation_biomarker_diagnosis_ns hsa-mir-142 "Carcinoma, Colon" 27485599 "diagnostic four-microRNA signature consisting of miR-23a-3p, miR-27a-3p, miR-142-5p and miR-376c-3p was established (AUC = 0.917), distinguishing colon cancer patients from healthy donors." -circulation_biomarker_diagnosis_ns hsa-mir-23a "Carcinoma, Colon" 27485599 "A diagnostic four-microRNA signature consisting of miR-23a-3p, miR-27a-3p, miR-142-5p and miR-376c-3p was established (AUC = 0.917), distinguishing colon cancer patients from healthy donors with sensitivity of 89% and specificity of 81% (AUC = 0.922)." -circulation_biomarker_diagnosis_ns hsa-mir-27a "Carcinoma, Colon" 27485599 "A diagnostic four-microRNA signature consisting of miR-23a-3p, miR-27a-3p, miR-142-5p and miR-376c-3p was established (AUC = 0.917), distinguishing colon cancer patients from healthy donors with sensitivity of 89% and specificity of 81% (AUC = 0.922)." -circulation_biomarker_diagnosis_ns hsa-mir-376c "Carcinoma, Colon" 27485599 "A diagnostic four-microRNA signature consisting of miR-23a-3p, miR-27a-3p, miR-142-5p and miR-376c-3p was established (AUC = 0.917), distinguishing colon cancer patients from healthy donors with sensitivity of 89% and specificity of 81% (AUC = 0.922)." -circulation_biomarker_diagnosis_ns hsa-mir-206 Muscular Dystrophy 27529242 "miR-206 has potential as a ""liquid biopsy"" for carrier detection and genetic counseling in DMD." -circulation_biomarker_diagnosis_ns hsa-mir-221 Pancreatic Neoplasms 27539232 "Circulating microRNAs as Potential Diagnostic, Prognostic and Therapeutic Targets in Pancreatic Cancer." -circulation_biomarker_diagnosis_ns hsa-mir-96 Pancreatic Neoplasms 27539232 "Circulating microRNAs as Potential Diagnostic, Prognostic and Therapeutic Targets in Pancreatic Cancer." -circulation_biomarker_diagnosis_ns hsa-mir-26b Graft-Versus-Host Disease 27553380 The predictive value of selected serum microRNAs for acute GVHD by TaqMan MicroRNA arrays. -circulation_biomarker_diagnosis_ns hsa-mir-28 Graft-Versus-Host Disease 27553380 The predictive value of selected serum microRNAs for acute GVHD by TaqMan MicroRNA arrays. -circulation_biomarker_diagnosis_ns hsa-mir-374a Graft-Versus-Host Disease 27553380 The predictive value of selected serum microRNAs for acute GVHD by TaqMan MicroRNA arrays. -circulation_biomarker_diagnosis_ns hsa-mir-411 Graft-Versus-Host Disease 27553380 The predictive value of selected serum microRNAs for acute GVHD by TaqMan MicroRNA arrays. -circulation_biomarker_diagnosis_ns hsa-mir-489 Graft-Versus-Host Disease 27553380 The predictive value of selected serum microRNAs for acute GVHD by TaqMan MicroRNA arrays. -circulation_biomarker_diagnosis_ns hsa-mir-671 Graft-Versus-Host Disease 27553380 The predictive value of selected serum microRNAs for acute GVHD by TaqMan MicroRNA arrays. -circulation_biomarker_diagnosis_ns hsa-mir-23a "Squamous Cell Carcinoma, Esophageal" 27566562 Plasma microRNA profiles: identification of miR-23a as a novel biomarker for chemoresistance in esophageal squamous cell carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-21 Acute Coronary Syndrome 27590242 The role of serum levels of microRNA-21 and matrix metalloproteinase-9 in patients with acute coronary syndrome. -circulation_biomarker_diagnosis_ns hsa-mir-122 Acute Myocardial Infarction 27593229 Circulating miR-122-5p/miR-133b Ratio Is a Specific Early Prognostic Biomarker in Acute Myocardial Infarction. -circulation_biomarker_diagnosis_ns hsa-mir-133b Acute Myocardial Infarction 27593229 Circulating miR-122-5p/miR-133b Ratio Is a Specific Early Prognostic Biomarker in Acute Myocardial Infarction. -circulation_biomarker_diagnosis_ns hsa-mir-21 Hepatoblastoma 27601233 Diagnostic and prognostic values of serum exosomal microRNA-21 in children with hepatoblastoma: a Chinese population-based study. -circulation_biomarker_diagnosis_ns hsa-mir-208a Coronary Artery Disease 27602213 Analysis of plasma miR-208a and miR-370 expression levels for early diagnosis of coronary artery disease. -circulation_biomarker_diagnosis_ns hsa-mir-370 Coronary Artery Disease 27602213 Analysis of plasma miR-208a and miR-370 expression levels for early diagnosis of coronary artery disease. -circulation_biomarker_diagnosis_ns hsa-mir-27a Multiple Sclerosis 27606352 Comprehensive evaluation of serum microRNAs as biomarkers in multiple sclerosis. -circulation_biomarker_diagnosis_ns hsa-mir-206 "Carcinoma, Gastric" 27614739 Diagnostic and Prognostic Value of Serum MicroRNA-206 in Patients with Gastric Cancer. -circulation_biomarker_diagnosis_ns hsa-mir-22 "Carcinoma, Pancreatic" 27631726 "Plasma miR-22-3p, miR-642b-3p and miR-885-5p as diagnostic biomarkers for pancreatic cancer." -circulation_biomarker_diagnosis_ns hsa-mir-642b "Carcinoma, Pancreatic" 27631726 "Plasma miR-22-3p, miR-642b-3p and miR-885-5p as diagnostic biomarkers for pancreatic cancer." -circulation_biomarker_diagnosis_ns hsa-mir-885 "Carcinoma, Pancreatic" 27631726 "Plasma miR-22-3p, miR-642b-3p and miR-885-5p as diagnostic biomarkers for pancreatic cancer." -circulation_biomarker_diagnosis_ns hsa-mir-122 Colorectal Carcinoma 27632639 Plasma miR-122 and miR-200 family are prognostic markers in colorectal cancer. -circulation_biomarker_diagnosis_ns hsa-mir-200 Colorectal Carcinoma 27632639 Plasma miR-122 and miR-200 family are prognostic markers in colorectal cancer. -circulation_biomarker_diagnosis_ns hsa-mir-139 "Carcinoma, Hepatocellular" 27633066 Reanalysis of microRNA expression profiles identifies novel biomarkers for hepatocellular carcinoma prognosis. -circulation_biomarker_diagnosis_ns hsa-let-7f Liver Diseases [unspecific] 27639178 Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood. -circulation_biomarker_diagnosis_ns hsa-mir-29a Liver Diseases [unspecific] 27639178 Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood. -circulation_biomarker_diagnosis_ns hsa-mir-340 Liver Diseases [unspecific] 27639178 Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood. -circulation_biomarker_diagnosis_ns hsa-mir-25 "Carcinoma, Pancreatic" 27639768 Identification of Circulating MiR-25 as a Potential Biomarker for Pancreatic Cancer Diagnosis. -circulation_biomarker_diagnosis_ns hsa-mir-1 Aplastic Anemia 27658437 A plasma microRNA signature as a biomarker for acquired aplastic anemia. -circulation_biomarker_diagnosis_ns hsa-mir-146b Aplastic Anemia 27658437 A plasma microRNA signature as a biomarker for acquired aplastic anemia. -circulation_biomarker_diagnosis_ns hsa-mir-150 Aplastic Anemia 27658437 A plasma microRNA signature as a biomarker for acquired aplastic anemia. -circulation_biomarker_diagnosis_ns hsa-mir-125b Age-Related Macular Degeneration 27658786 "mir-17, miR-125b and miR-155 were dysregulated in multiple AMD mouse models as well as in human AMD plasma or retinae" -circulation_biomarker_diagnosis_ns hsa-mir-155 Age-Related Macular Degeneration 27658786 "mir-17, miR-125b and miR-155 were dysregulated in multiple AMD mouse models as well as in human AMD plasma or retinae" -circulation_biomarker_diagnosis_ns hsa-mir-17 Age-Related Macular Degeneration 27658786 "mir-17, miR-125b and miR-155 were dysregulated in multiple AMD mouse models as well as in human AMD plasma or retinae" -circulation_biomarker_diagnosis_ns hsa-mir-33a Atherosclerosis 27664032 Aberrant expression of plasma microRNA-33a in an atherosclerosis-risk group. -circulation_biomarker_diagnosis_ns hsa-let-7g "Tuberculosis, Pulmonary" 27682490 The expression of serum miRNAs in pneumoconiosis complicated with pulmonary tuberculosis patients. -circulation_biomarker_diagnosis_ns hsa-mir-155 "Tuberculosis, Pulmonary" 27682490 The expression of serum miRNAs in pneumoconiosis complicated with pulmonary tuberculosis patients. -circulation_biomarker_diagnosis_ns hsa-mir-16 "Tuberculosis, Pulmonary" 27682490 The expression of serum miRNAs in pneumoconiosis complicated with pulmonary tuberculosis patients. -circulation_biomarker_diagnosis_ns hsa-mir-192 "Tuberculosis, Pulmonary" 27682490 The expression of serum miRNAs in pneumoconiosis complicated with pulmonary tuberculosis patients. -circulation_biomarker_diagnosis_ns hsa-mir-200c "Tuberculosis, Pulmonary" 27682490 The expression of serum miRNAs in pneumoconiosis complicated with pulmonary tuberculosis patients. -circulation_biomarker_diagnosis_ns hsa-mir-204 "Tuberculosis, Pulmonary" 27682490 The expression of serum miRNAs in pneumoconiosis complicated with pulmonary tuberculosis patients. -circulation_biomarker_diagnosis_ns hsa-mir-206 "Tuberculosis, Pulmonary" 27682490 The expression of serum miRNAs in pneumoconiosis complicated with pulmonary tuberculosis patients. -circulation_biomarker_diagnosis_ns hsa-mir-21 "Tuberculosis, Pulmonary" 27682490 The expression of serum miRNAs in pneumoconiosis complicated with pulmonary tuberculosis patients. -circulation_biomarker_diagnosis_ns hsa-mir-29a "Tuberculosis, Pulmonary" 27682490 The expression of serum miRNAs in pneumoconiosis complicated with pulmonary tuberculosis patients. -circulation_biomarker_diagnosis_ns hsa-mir-30b "Tuberculosis, Pulmonary" 27682490 The expression of serum miRNAs in pneumoconiosis complicated with pulmonary tuberculosis patients. -circulation_biomarker_diagnosis_ns hsa-mir-21 Cholangiocarcinoma 27685844 Circulating Plasma Levels of MicroRNA-21 and MicroRNA-221 Are Potential Diagnostic Markers for Primary Intrahepatic Cholangiocarcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-221 Cholangiocarcinoma 27685844 Circulating Plasma Levels of MicroRNA-21 and MicroRNA-221 Are Potential Diagnostic Markers for Primary Intrahepatic Cholangiocarcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-23a Cardiovascular Diseases [unspecific] 27725938 Optimized Collection Protocol for Plasma MicroRNA Measurement in Patients with Cardiovascular Disease. -circulation_biomarker_diagnosis_ns hsa-mir-451a Cardiovascular Diseases [unspecific] 27725938 Optimized Collection Protocol for Plasma MicroRNA Measurement in Patients with Cardiovascular Disease. -circulation_biomarker_diagnosis_ns hsa-mir-150 "Leukemia, Lymphocytic, Chronic, B-Cell" 27730344 Expression of circulating miRNAs associated with lymphocyte differentiation and activation in CLL-another piece in the puzzle. -circulation_biomarker_diagnosis_ns hsa-mir-155 "Leukemia, Lymphocytic, Chronic, B-Cell" 27730344 Expression of circulating miRNAs associated with lymphocyte differentiation and activation in CLL-another piece in the puzzle. -circulation_biomarker_diagnosis_ns hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 27730344 Expression of circulating miRNAs associated with lymphocyte differentiation and activation in CLL-another piece in the puzzle. -circulation_biomarker_diagnosis_ns hsa-mir-29a "Leukemia, Lymphocytic, Chronic, B-Cell" 27730344 Expression of circulating miRNAs associated with lymphocyte differentiation and activation in CLL-another piece in the puzzle. -circulation_biomarker_diagnosis_ns hsa-mir-31 "Leukemia, Lymphocytic, Chronic, B-Cell" 27730344 Expression of circulating miRNAs associated with lymphocyte differentiation and activation in CLL-another piece in the puzzle. -circulation_biomarker_diagnosis_ns hsa-mir-34a "Leukemia, Lymphocytic, Chronic, B-Cell" 27730344 Expression of circulating miRNAs associated with lymphocyte differentiation and activation in CLL-another piece in the puzzle. -circulation_biomarker_diagnosis_ns hsa-mir-195 "Carcinoma, Lung, Non-Small-Cell" 27733164 Diagnostic and prognostic value of plasma microRNA-195 in patients with non-small cell lung cancer. -circulation_biomarker_diagnosis_ns hsa-mir-497 Osteosarcoma 27735043 miR-497 as a potential serum biomarker for the diagnosis and prognosis of osteosarcoma. -circulation_biomarker_diagnosis_ns hsa-mir-221 Parkinson Disease 27748571 Serum miR-221 serves as a biomarker for Parkinson's disease. -circulation_biomarker_diagnosis_ns hsa-mir-155 "Carcinoma, Hepatocellular" 27751368 Relationship Between Serum microRNA155 and Telomerase Expression in Hepatocellular Carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-146a Ischemia-Reperfusion Injury 27760486 Micro RNA-320 as a novel potential biomarker in renal ischemia reperfusion. -circulation_biomarker_diagnosis_ns hsa-mir-155 Hematologic Neoplasms 27761889 "EV miR155 may serve as an attractive new, non-invasive diagnostic biomarker in human hematologic malignancies" -circulation_biomarker_diagnosis_ns hsa-mir-183 "Carcinoma, Lung" 27768748 Plasma miR-19b and miR-183 as Potential Biomarkers of Lung Cancer. -circulation_biomarker_diagnosis_ns hsa-mir-19b "Carcinoma, Lung" 27768748 Plasma miR-19b and miR-183 as Potential Biomarkers of Lung Cancer. -circulation_biomarker_diagnosis_ns hsa-let-7e "Stroke, Ischemic" 27776139 Identification of Blood Let-7e-5p as a Biomarker for Ischemic Stroke. -circulation_biomarker_diagnosis_ns hsa-mir-21 Atherosclerosis 27785570 "Association of serum microRNA-21 levels with Visfatin, inflammation, and acute coronary syndromes." -circulation_biomarker_diagnosis_ns hsa-mir-150 "Carcinoma, Colon" 27798914 "miR-21, miR-221 and miR-150 Are Deregulated in Peripheral Blood of Patients with Colorectal Cancer." -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Colon" 27798914 "miR-21, miR-221 and miR-150 Are Deregulated in Peripheral Blood of Patients with Colorectal Cancer." -circulation_biomarker_diagnosis_ns hsa-mir-221 "Carcinoma, Colon" 27798914 "miR-21, miR-221 and miR-150 Are Deregulated in Peripheral Blood of Patients with Colorectal Cancer." -circulation_biomarker_diagnosis_ns hsa-mir-15a "Squamous Cell Carcinoma, Esophageal" 27802201 Serum microRNA-15a level acts as a potential diagnostic and prognostic biomarker for human esophageal squamous cell carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-106a "Carcinoma, Renal Cell" 27814278 Functional analysis of serum microRNAs miR-21 and miR-106a in renal cell carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Renal Cell" 27814278 Functional analysis of serum microRNAs miR-21 and miR-106a in renal cell carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-181a Systemic Lupus Erythematosus 27816459 "MicroRNA-21, microRNA-181a and microRNA-196a as potential biomarkers in adult Egyptian patients with systemic lupus erythematosus." -circulation_biomarker_diagnosis_ns hsa-mir-196a Systemic Lupus Erythematosus 27816459 "MicroRNA-21, microRNA-181a and microRNA-196a as potential biomarkers in adult Egyptian patients with systemic lupus erythematosus." -circulation_biomarker_diagnosis_ns hsa-mir-21 Systemic Lupus Erythematosus 27816459 "MicroRNA-21, microRNA-181a and microRNA-196a as potential biomarkers in adult Egyptian patients with systemic lupus erythematosus." -circulation_biomarker_diagnosis_ns hsa-mir-143 Mesial Temporal Lobe Epilepsy 27833019 Changes in serum miRNAs following generalized convulsive seizures in human mesial temporal lobe epilepsy. -circulation_biomarker_diagnosis_ns hsa-mir-145 Mesial Temporal Lobe Epilepsy 27833019 Changes in serum miRNAs following generalized convulsive seizures in human mesial temporal lobe epilepsy. -circulation_biomarker_diagnosis_ns hsa-mir-365a Mesial Temporal Lobe Epilepsy 27833019 Changes in serum miRNAs following generalized convulsive seizures in human mesial temporal lobe epilepsy. -circulation_biomarker_diagnosis_ns hsa-mir-532 Mesial Temporal Lobe Epilepsy 27833019 Changes in serum miRNAs following generalized convulsive seizures in human mesial temporal lobe epilepsy. -circulation_biomarker_diagnosis_ns hsa-mir-663b Mesial Temporal Lobe Epilepsy 27833019 Changes in serum miRNAs following generalized convulsive seizures in human mesial temporal lobe epilepsy. -circulation_biomarker_diagnosis_ns hsa-mir-221 Systemic Lupus Erythematosus 27835701 High-Throughput Sequencing Reveals Circulating miRNAs as Potential Biomarkers of Kidney Damage in Patients with Systemic Lupus Erythematosus. -circulation_biomarker_diagnosis_ns hsa-mir-3074 Systemic Lupus Erythematosus 27835701 High-Throughput Sequencing Reveals Circulating miRNAs as Potential Biomarkers of Kidney Damage in Patients with Systemic Lupus Erythematosus. -circulation_biomarker_diagnosis_ns hsa-mir-380 Systemic Lupus Erythematosus 27835701 High-Throughput Sequencing Reveals Circulating miRNAs as Potential Biomarkers of Kidney Damage in Patients with Systemic Lupus Erythematosus. -circulation_biomarker_diagnosis_ns hsa-mir-556 Systemic Lupus Erythematosus 27835701 High-Throughput Sequencing Reveals Circulating miRNAs as Potential Biomarkers of Kidney Damage in Patients with Systemic Lupus Erythematosus. -circulation_biomarker_diagnosis_ns hsa-mir-758 Systemic Lupus Erythematosus 27835701 High-Throughput Sequencing Reveals Circulating miRNAs as Potential Biomarkers of Kidney Damage in Patients with Systemic Lupus Erythematosus. -circulation_biomarker_diagnosis_ns hsa-mir-106b Epilepsy 27840934 Identification of serum miRNAs differentially expressed in human epilepsy at seizure onset and post-seizure. -circulation_biomarker_diagnosis_ns hsa-mir-15a Epilepsy 27840934 Identification of serum miRNAs differentially expressed in human epilepsy at seizure onset and post-seizure. -circulation_biomarker_diagnosis_ns hsa-mir-30a Epilepsy 27840934 Identification of serum miRNAs differentially expressed in human epilepsy at seizure onset and post-seizure. -circulation_biomarker_diagnosis_ns hsa-mir-378 Epilepsy 27840934 Identification of serum miRNAs differentially expressed in human epilepsy at seizure onset and post-seizure. -circulation_biomarker_diagnosis_ns hsa-mir-16 Acute Cerebral Infarction 27846323 "Plasma MicroRNA-16 Is a Biomarker for Diagnosis, Stratification, and Prognosis of Hyperacute Cerebral Infarction." -circulation_biomarker_diagnosis_ns hsa-mir-1266 Atrial Fibrillation 27855199 The Values of Coronary Circulating miRNAs in Patients with Atrial Fibrillation. -circulation_biomarker_diagnosis_ns hsa-mir-3149 Atrial Fibrillation 27855199 The Values of Coronary Circulating miRNAs in Patients with Atrial Fibrillation. -circulation_biomarker_diagnosis_ns hsa-mir-3171 Atrial Fibrillation 27855199 The Values of Coronary Circulating miRNAs in Patients with Atrial Fibrillation. -circulation_biomarker_diagnosis_ns hsa-mir-4279 Atrial Fibrillation 27855199 The Values of Coronary Circulating miRNAs in Patients with Atrial Fibrillation. -circulation_biomarker_diagnosis_ns hsa-mir-4666a Atrial Fibrillation 27855199 The Values of Coronary Circulating miRNAs in Patients with Atrial Fibrillation. -circulation_biomarker_diagnosis_ns hsa-mir-892a Atrial Fibrillation 27855199 The Values of Coronary Circulating miRNAs in Patients with Atrial Fibrillation. -circulation_biomarker_diagnosis_ns hsa-mir-222 Neoplasms [unspecific] 27859748 Use of Serum MicroRNAs as Biomarker for Hepatobiliary Diseases in Dogs. -circulation_biomarker_diagnosis_ns hsa-mir-126 "Diabetes Mellitus, Type 2" 27869909 Altered levels of circulating cytokines and microRNAs in lean and obese individuals with prediabetes and type 2 diabetes. -circulation_biomarker_diagnosis_ns hsa-mir-146a "Diabetes Mellitus, Type 2" 27869909 Altered levels of circulating cytokines and microRNAs in lean and obese individuals with prediabetes and type 2 diabetes. -circulation_biomarker_diagnosis_ns hsa-mir-148 "Diabetes Mellitus, Type 2" 27869909 Altered levels of circulating cytokines and microRNAs in lean and obese individuals with prediabetes and type 2 diabetes. -circulation_biomarker_diagnosis_ns hsa-mir-150 "Diabetes Mellitus, Type 2" 27869909 Altered levels of circulating cytokines and microRNAs in lean and obese individuals with prediabetes and type 2 diabetes. -circulation_biomarker_diagnosis_ns hsa-mir-155 "Diabetes Mellitus, Type 2" 27869909 Altered levels of circulating cytokines and microRNAs in lean and obese individuals with prediabetes and type 2 diabetes. -circulation_biomarker_diagnosis_ns hsa-mir-21 "Diabetes Mellitus, Type 2" 27869909 Altered levels of circulating cytokines and microRNAs in lean and obese individuals with prediabetes and type 2 diabetes. -circulation_biomarker_diagnosis_ns hsa-mir-223 "Diabetes Mellitus, Type 2" 27869909 Altered levels of circulating cytokines and microRNAs in lean and obese individuals with prediabetes and type 2 diabetes. -circulation_biomarker_diagnosis_ns hsa-mir-24 "Diabetes Mellitus, Type 2" 27869909 Altered levels of circulating cytokines and microRNAs in lean and obese individuals with prediabetes and type 2 diabetes. -circulation_biomarker_diagnosis_ns hsa-mir-27a "Diabetes Mellitus, Type 2" 27869909 Altered levels of circulating cytokines and microRNAs in lean and obese individuals with prediabetes and type 2 diabetes. -circulation_biomarker_diagnosis_ns hsa-mir-28 "Diabetes Mellitus, Type 2" 27869909 Altered levels of circulating cytokines and microRNAs in lean and obese individuals with prediabetes and type 2 diabetes. -circulation_biomarker_diagnosis_ns hsa-mir-29b "Diabetes Mellitus, Type 2" 27869909 Altered levels of circulating cytokines and microRNAs in lean and obese individuals with prediabetes and type 2 diabetes. -circulation_biomarker_diagnosis_ns hsa-mir-30d "Diabetes Mellitus, Type 2" 27869909 Altered levels of circulating cytokines and microRNAs in lean and obese individuals with prediabetes and type 2 diabetes. -circulation_biomarker_diagnosis_ns hsa-mir-34a "Diabetes Mellitus, Type 2" 27869909 Altered levels of circulating cytokines and microRNAs in lean and obese individuals with prediabetes and type 2 diabetes. -circulation_biomarker_diagnosis_ns hsa-mir-93 "Diabetes Mellitus, Type 2" 27869909 Altered levels of circulating cytokines and microRNAs in lean and obese individuals with prediabetes and type 2 diabetes. -circulation_biomarker_diagnosis_ns hsa-mir-155 "Carcinoma, Colon" 27872469 Preoperative Serum MicroRNA-155 Expression Independently Predicts Postoperative Cognitive Dysfunction After Laparoscopic Surgery for Colon Cancer. -circulation_biomarker_diagnosis_ns hsa-mir-34a "Carcinoma, Hepatocellular" 27893432 MicroRNA-34a expression levels in serum and intratumoral tissue can predict bone metastasis in patients with hepatocellular carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-126 Arteriosclerosis Obliterans 27900989 Negative Association of Circulating MicroRNA-126 with High-sensitive C-reactive Protein and Vascular Cell Adhesion Molecule-1 in Patients with Coronary Artery Disease Following Percutaneous Coronary Intervention. -circulation_biomarker_diagnosis_ns hsa-mir-103 "Carcinoma, Gastric" 27909811 "Plasma microRNA-103, microRNA-107, and microRNA-194 levels are not biomarkers for human diffuse gastric cancer." -circulation_biomarker_diagnosis_ns hsa-mir-107 "Carcinoma, Gastric" 27909811 "Plasma microRNA-103, microRNA-107, and microRNA-194 levels are not biomarkers for human diffuse gastric cancer." -circulation_biomarker_diagnosis_ns hsa-mir-194 "Carcinoma, Gastric" 27909811 "Plasma microRNA-103, microRNA-107, and microRNA-194 levels are not biomarkers for human diffuse gastric cancer." -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Colon" 27910062 Plasma and saliva miR-21 expression in colorectal cancer patients. -circulation_biomarker_diagnosis_ns hsa-mir-21 Osteosarcoma 27922432 miR-21 predicts poor prognosis in patients with osteosarcoma. -circulation_biomarker_diagnosis_ns hsa-mir-133 Cardiomyopathy 27922664 Expression of Bcl-2 and microRNAs in cardiac tissues of patients with dilated cardiomyopathy. -circulation_biomarker_diagnosis_ns hsa-mir-133a Cardiomyopathy 27922664 Expression of Bcl-2 and microRNAs in cardiac tissues of patients with dilated cardiomyopathy. -circulation_biomarker_diagnosis_ns hsa-mir-133b Cardiomyopathy 27922664 Expression of Bcl-2 and microRNAs in cardiac tissues of patients with dilated cardiomyopathy. -circulation_biomarker_diagnosis_ns hsa-mir-21 Cardiomyopathy 27922664 Expression of Bcl-2 and microRNAs in cardiac tissues of patients with dilated cardiomyopathy. -circulation_biomarker_diagnosis_ns hsa-mir-29 Cardiomyopathy 27922664 Expression of Bcl-2 and microRNAs in cardiac tissues of patients with dilated cardiomyopathy. -circulation_biomarker_diagnosis_ns hsa-mir-29a Cardiomyopathy 27922664 Expression of Bcl-2 and microRNAs in cardiac tissues of patients with dilated cardiomyopathy. -circulation_biomarker_diagnosis_ns hsa-mir-29b Cardiomyopathy 27922664 Expression of Bcl-2 and microRNAs in cardiac tissues of patients with dilated cardiomyopathy. -circulation_biomarker_diagnosis_ns hsa-mir-29c Cardiomyopathy 27922664 Expression of Bcl-2 and microRNAs in cardiac tissues of patients with dilated cardiomyopathy. -circulation_biomarker_diagnosis_ns hsa-mir-126 Cardiovascular Diseases [unspecific] 27924211 Circulating miR-126 and miR-499 reflect progression of cardiovascular disease; correlations with uric acid and ejection fraction. -circulation_biomarker_diagnosis_ns hsa-mir-122 "Fatty Liver, Non-Alcoholic" 27955628 Analysis of association between circulating miR-122 and histopathological features of nonalcoholic fatty liver disease in patients free of hepatocellular carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-34a "Fatty Liver, Non-Alcoholic" 27956809 Disease-specific miR-34a as diagnostic marker of non-alcoholic steatohepatitis in a Chinese population. -circulation_biomarker_diagnosis_ns hsa-mir-21 Ischemia-Reperfusion Injury 27979484 MicroRNA-125b as a new potential biomarker on diagnosis of renal ischemia-reperfusion injury. -circulation_biomarker_diagnosis_ns hsa-mir-199a Glioma 27981547 Circulating miR-199a-3p in plasma and its potential diagnostic and prognostic value in glioma. -circulation_biomarker_diagnosis_ns hsa-mir-125 "Carcinoma, Gastric" 27986464 Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer. -circulation_biomarker_diagnosis_ns hsa-mir-125b "Lymphoma, Burkitt" 27991481 "Circulating MicroRNA-21, MicroRNA-23a, and MicroRNA-125b as Biomarkers for Diagnosis and Prognosis of Burkitt Lymphoma in Children." -circulation_biomarker_diagnosis_ns hsa-mir-21 "Lymphoma, Burkitt" 27991481 "Circulating MicroRNA-21, MicroRNA-23a, and MicroRNA-125b as Biomarkers for Diagnosis and Prognosis of Burkitt Lymphoma in Children." -circulation_biomarker_diagnosis_ns hsa-mir-23a "Lymphoma, Burkitt" 27991481 "Circulating MicroRNA-21, MicroRNA-23a, and MicroRNA-125b as Biomarkers for Diagnosis and Prognosis of Burkitt Lymphoma in Children." -circulation_biomarker_diagnosis_ns hsa-mir-29a Atherosclerosis 27997904 The Relationship of Plasma miR-29a and Oxidized Low Density Lipoprotein with Atherosclerosis. -circulation_biomarker_diagnosis_ns hsa-mir-181a Acute Myocardial Infarction 27997916 Circulating miR-181a as a Potential Novel Biomarker for Diagnosis of Acute Myocardial Infarction. -circulation_biomarker_diagnosis_ns hsa-mir-135a Colorectal Carcinoma 27998467 Expression and significance of serum microRNA-135a-5p level in colorectal cancer. -circulation_biomarker_diagnosis_ns hsa-mir-155 "Carcinoma, Lung, Non-Small-Cell" 28002496 "a combination of miRs 21, 205, 155 and possibly other miRs as serum biomarkers for early detection of NSCLC" -circulation_biomarker_diagnosis_ns hsa-mir-205 "Carcinoma, Lung, Non-Small-Cell" 28002496 "a combination of miRs 21, 205, 155 and possibly other miRs as serum biomarkers for early detection of NSCLC" -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 28002496 "a combination of miRs 21, 205, 155 and possibly other miRs as serum biomarkers for early detection of NSCLC" -circulation_biomarker_diagnosis_ns hsa-mir-1246 "Carcinoma, Ovarian, Serous" 28017893 Circulating miRNA landscape identifies miR-1246 as promising diagnostic biomarker in high-grade serous ovarian carcinoma: A validation across two independent cohorts. -circulation_biomarker_diagnosis_ns hsa-mir-375 "Squamous Cell Carcinoma, Oral" 28030794 Circulating miRNAs as biomarkers for oral squamous cell carcinoma recurrence in operated patients. -circulation_biomarker_diagnosis_ns hsa-mir-10b "Carcinoma, Hepatocellular" 28049231 An Explorative Analysis for the Role of Serum miR-10b-3p Levels in Predicting Response to Sorafenib in Patients with Advanced Hepatocellular Carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-1 Lofgren Syndrome 28050119 The Serum Expression of Selected miRNAs in Pulmonary Sarcoidosis with/without L?fgren's Syndrome. -circulation_biomarker_diagnosis_ns hsa-mir-146 Lofgren Syndrome 28050119 The Serum Expression of Selected miRNAs in Pulmonary Sarcoidosis with/without L?fgren's Syndrome. -circulation_biomarker_diagnosis_ns hsa-mir-150 Lofgren Syndrome 28050119 The Serum Expression of Selected miRNAs in Pulmonary Sarcoidosis with/without L?fgren's Syndrome. -circulation_biomarker_diagnosis_ns hsa-mir-16 Lofgren Syndrome 28050119 The Serum Expression of Selected miRNAs in Pulmonary Sarcoidosis with/without L?fgren's Syndrome. -circulation_biomarker_diagnosis_ns hsa-mir-21 Lofgren Syndrome 28050119 The Serum Expression of Selected miRNAs in Pulmonary Sarcoidosis with/without L?fgren's Syndrome. -circulation_biomarker_diagnosis_ns hsa-mir-212 Lofgren Syndrome 28050119 The Serum Expression of Selected miRNAs in Pulmonary Sarcoidosis with/without L?fgren's Syndrome. -circulation_biomarker_diagnosis_ns hsa-mir-340 Lofgren Syndrome 28050119 The Serum Expression of Selected miRNAs in Pulmonary Sarcoidosis with/without L?fgren's Syndrome. -circulation_biomarker_diagnosis_ns hsa-mir-425 Lofgren Syndrome 28050119 The Serum Expression of Selected miRNAs in Pulmonary Sarcoidosis with/without L?fgren's Syndrome. -circulation_biomarker_diagnosis_ns hsa-mir-93 Lofgren Syndrome 28050119 The Serum Expression of Selected miRNAs in Pulmonary Sarcoidosis with/without L?fgren's Syndrome. -circulation_biomarker_diagnosis_ns hsa-mir-145 Acute Myocardial Infarction 28051023 Circulating MicroRNA-145 is Associated with Acute Myocardial Infarction and Heart Failure. -circulation_biomarker_diagnosis_ns hsa-mir-99a Acute Myocardial Infarction 28051249 The clinical value of circulating miR-99a in plasma of patients with acute myocardial infarction. -circulation_biomarker_diagnosis_ns hsa-mir-378 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 28051256 Expression of serum microRNA-378 and its clinical significance in laryngeal squamous cell carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-1 Heart Failure 28052002 Circulating miR-1 as a potential biomarker of doxorubicin-induced cardiotoxicity in breast cancer patients. -circulation_biomarker_diagnosis_ns hsa-mir-10b "Carcinoma, Lung, Non-Small-Cell" 28055956 Circulating exosomal microRNAs as prognostic biomarkers for non-small-cell lung cancer. -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 28055956 Circulating exosomal microRNAs as prognostic biomarkers for non-small-cell lung cancer. -circulation_biomarker_diagnosis_ns hsa-mir-23b "Carcinoma, Lung, Non-Small-Cell" 28055956 Circulating exosomal microRNAs as prognostic biomarkers for non-small-cell lung cancer. -circulation_biomarker_diagnosis_ns hsa-mir-192 Kidney Injury 28056546 Urinary MicroRNA-30c-5p and MicroRNA-192-5p as potential biomarkers of ischemia-reperfusion-induced kidney injury. -circulation_biomarker_diagnosis_ns hsa-mir-30c Kidney Injury 28056546 Urinary MicroRNA-30c-5p and MicroRNA-192-5p as potential biomarkers of ischemia-reperfusion-induced kidney injury. -circulation_biomarker_diagnosis_ns hsa-mir-132 "Carcinoma, Breast" 28058628 A pilot study on plasma levels of micro-RNAs involved in angiogenesis and vascular maturation in patients with breast cancer. -circulation_biomarker_diagnosis_ns hsa-mir-221 "Carcinoma, Breast" 28058628 A pilot study on plasma levels of micro-RNAs involved in angiogenesis and vascular maturation in patients with breast cancer. -circulation_biomarker_diagnosis_ns hsa-mir-27b "Carcinoma, Breast" 28058628 A pilot study on plasma levels of micro-RNAs involved in angiogenesis and vascular maturation in patients with breast cancer. -circulation_biomarker_diagnosis_ns hsa-mir-221 "Carcinoma, Thyroid, Papillary" 28061868 "MiR-221, a potential prognostic biomarker for recurrence in papillary thyroid cancer." -circulation_biomarker_diagnosis_ns hsa-mir-122 Liver Diseases [unspecific] 28070111 "circulating liver-specific miR-122 and miR-192 levels also increased 24 hr or later compared with ALT, suggesting that circulating miR-122 and miR-192 may serve as potential biomarkers to detect hepatotoxicity in cynomolgus monkeys" -circulation_biomarker_diagnosis_ns hsa-mir-192 Liver Diseases [unspecific] 28070111 "circulating liver-specific miR-122 and miR-192 levels also increased 24 hr or later compared with ALT, suggesting that circulating miR-122 and miR-192 may serve as potential biomarkers to detect hepatotoxicity in cynomolgus monkeys" -circulation_biomarker_diagnosis_ns hsa-let-7a Chronic Kidney Disease 28077372 "miRNA are associated with kidney fibrosis, and specific urinary and plasma miRNA profile may have diagnostic and prognostic utility in CKD" -circulation_biomarker_diagnosis_ns hsa-mir-1281 Chronic Kidney Disease 28077372 "miRNA are associated with kidney fibrosis, and specific urinary and plasma miRNA profile may have diagnostic and prognostic utility in CKD" -circulation_biomarker_diagnosis_ns hsa-mir-130a Chronic Kidney Disease 28077372 "miRNA are associated with kidney fibrosis, and specific urinary and plasma miRNA profile may have diagnostic and prognostic utility in CKD" -circulation_biomarker_diagnosis_ns hsa-mir-1825 Chronic Kidney Disease 28077372 "miRNA are associated with kidney fibrosis, and specific urinary and plasma miRNA profile may have diagnostic and prognostic utility in CKD" -circulation_biomarker_diagnosis_ns hsa-mir-423 Chronic Kidney Disease 28077372 "miRNA are associated with kidney fibrosis, and specific urinary and plasma miRNA profile may have diagnostic and prognostic utility in CKD" -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Breast, Triple Negative" 28078851 Mechanism of serum miR-21 in the pathogenesis of familial and triple negative breast cancer. -circulation_biomarker_diagnosis_ns hsa-mir-107 "Carcinoma, Hepatocellular" 28079796 Serum microRNA panel for early diagnosis of the onset of hepatocellular carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-16 "Carcinoma, Hepatocellular" 28079796 Serum microRNA panel for early diagnosis of the onset of hepatocellular carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-3126 "Carcinoma, Hepatocellular" 28079796 Serum microRNA panel for early diagnosis of the onset of hepatocellular carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-92 "Carcinoma, Hepatocellular" 28079796 Serum microRNA panel for early diagnosis of the onset of hepatocellular carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-19b "Carcinoma, Prostate" 28091918 Changes in the Level of Circulating hsa-miR-297 and hsa-miR-19b-3p miRNA Are Associated with Generalization of Prostate Cancer. -circulation_biomarker_diagnosis_ns hsa-mir-297 "Carcinoma, Prostate" 28091918 Changes in the Level of Circulating hsa-miR-297 and hsa-miR-19b-3p miRNA Are Associated with Generalization of Prostate Cancer. -circulation_biomarker_diagnosis_ns hsa-mir-196a "Squamous Cell Carcinoma, Esophageal" 28095062 MicroRNA-196a as a Potential Diagnostic Biomarker for Esophageal Squamous Cell Carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-92a "Carcinoma, Lung, Small-Cell" 28106539 Plasma miR-92a-2 as a biomarker for small cell lung cancer. -circulation_biomarker_diagnosis_ns hsa-mir-142 Traumatic Brain Injury 28117263 Plasma micro-RNA biomarkers for diagnosis and prognosis after traumatic brain injury: A pilot study. -circulation_biomarker_diagnosis_ns hsa-mir-423 Traumatic Brain Injury 28117263 Plasma micro-RNA biomarkers for diagnosis and prognosis after traumatic brain injury: A pilot study. -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Gastric" 28121346 miR-21 can be used for the diagnosis of gastric cancer and prognosis of lymph node metastasis in gastric cancer -circulation_biomarker_diagnosis_ns hsa-mir-222 "Adenocarcinoma, Lung" 28123597 Identification of A Panel of Serum microRNAs as Biomarkers for Early Detection of Lung Adenocarcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-223 "Adenocarcinoma, Lung" 28123597 Identification of A Panel of Serum microRNAs as Biomarkers for Early Detection of Lung Adenocarcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-208b Myocardial Infarction 28164501 Circulating miR-208b: A Potentially Sensitive and Reliable Biomarker for the Diagnosis and Prognosis of Acute Myocardial Infarction. -circulation_biomarker_diagnosis_ns hsa-mir-146a Sepsis 28164567 The Prognostic Value of Plasma MicroRNA-155 and MicroRNA-146a Level in Severe Sepsis and Sepsis-Induced Acute Lung Injury Patients. -circulation_biomarker_diagnosis_ns hsa-mir-155 Sepsis 28164567 The Prognostic Value of Plasma MicroRNA-155 and MicroRNA-146a Level in Severe Sepsis and Sepsis-Induced Acute Lung Injury Patients. -circulation_biomarker_diagnosis_ns hsa-mir-19a Colorectal Carcinoma 28177881 A panel of microRNA signature in serum for colorectal cancer diagnosis. -circulation_biomarker_diagnosis_ns hsa-mir-21 Colorectal Carcinoma 28177881 A panel of microRNA signature in serum for colorectal cancer diagnosis. -circulation_biomarker_diagnosis_ns hsa-mir-425 Colorectal Carcinoma 28177881 A panel of microRNA signature in serum for colorectal cancer diagnosis. -circulation_biomarker_diagnosis_ns hsa-mir-23a Polycystic Ovarian Syndrome 28193283 Circulatory microRNA 23a and microRNA 23b and polycystic ovary syndrome (PCOS): the effects of body mass index and sex hormones in an Eastern Han Chinese population. -circulation_biomarker_diagnosis_ns hsa-mir-23b Polycystic Ovarian Syndrome 28193283 Circulatory microRNA 23a and microRNA 23b and polycystic ovary syndrome (PCOS): the effects of body mass index and sex hormones in an Eastern Han Chinese population. -circulation_biomarker_diagnosis_ns hsa-mir-145 Coronary Artery Disease 28205634 "Circulating miR-155, miR-145 and let-7c as diagnostic biomarkers of the coronary artery disease." -circulation_biomarker_diagnosis_ns hsa-mir-122 Chronic Hepatitis C 28211229 Serum microRNAs as predictors for liver fibrosis staging in hepatitis C virus-associated chronic liver disease patients. -circulation_biomarker_diagnosis_ns hsa-mir-107 "Neuralgia, Postherpetic" 28225487 Comparing serum microRNA levels of acute herpes zoster patients with those of postherpetic neuralgia patients. -circulation_biomarker_diagnosis_ns hsa-mir-127 "Neuralgia, Postherpetic" 28225487 Comparing serum microRNA levels of acute herpes zoster patients with those of postherpetic neuralgia patients. -circulation_biomarker_diagnosis_ns hsa-mir-34c "Neuralgia, Postherpetic" 28225487 Comparing serum microRNA levels of acute herpes zoster patients with those of postherpetic neuralgia patients. -circulation_biomarker_diagnosis_ns hsa-mir-486 "Neuralgia, Postherpetic" 28225487 Comparing serum microRNA levels of acute herpes zoster patients with those of postherpetic neuralgia patients. -circulation_biomarker_diagnosis_ns hsa-mir-892b "Neuralgia, Postherpetic" 28225487 Comparing serum microRNA levels of acute herpes zoster patients with those of postherpetic neuralgia patients. -circulation_biomarker_diagnosis_ns hsa-let-7a "Carcinoma, Pancreatic" 28232049 A microRNA signature in circulating exosomes is superior to exosomal glypican-1 levels for diagnosing pancreatic cancer. -circulation_biomarker_diagnosis_ns hsa-mir-10b "Carcinoma, Pancreatic" 28232049 A microRNA signature in circulating exosomes is superior to exosomal glypican-1 levels for diagnosing pancreatic cancer. -circulation_biomarker_diagnosis_ns hsa-mir-181a "Carcinoma, Pancreatic" 28232049 A microRNA signature in circulating exosomes is superior to exosomal glypican-1 levels for diagnosing pancreatic cancer. -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Pancreatic" 28232049 A microRNA signature in circulating exosomes is superior to exosomal glypican-1 levels for diagnosing pancreatic cancer. -circulation_biomarker_diagnosis_ns hsa-mir-30c "Carcinoma, Pancreatic" 28232049 A microRNA signature in circulating exosomes is superior to exosomal glypican-1 levels for diagnosing pancreatic cancer. -circulation_biomarker_diagnosis_ns hsa-mir-122 Hepatitis C Virus Infection 28232800 Circulating ECV-Associated miRNAs as Potential Clinical Biomarkers in Early Stage HBV and HCV Induced Liver Fibrosis. -circulation_biomarker_diagnosis_ns hsa-mir-200b Hepatitis C Virus Infection 28232800 Circulating ECV-Associated miRNAs as Potential Clinical Biomarkers in Early Stage HBV and HCV Induced Liver Fibrosis. -circulation_biomarker_diagnosis_ns hsa-mir-146b "Carcinoma, Bladder" 28239818 Identification of miR-146b-5p in tissues as a novel biomarker for prognosis of gallbladder carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-383 "Carcinoma, Gastric" 28243881 "The Value of MiR-383, an Intronic MiRNA, as a Diagnostic and Prognostic Biomarker in Intestinal-Type Gastric Cancer." -circulation_biomarker_diagnosis_ns hsa-mir-193a Focal Segmental Glomerulosclerosis 28246603 Urinary Exosomal miR-193a Can Be a Potential Biomarker for the Diagnosis of Primary Focal Segmental Glomerulosclerosis in Children. -circulation_biomarker_diagnosis_ns hsa-mir-126 "Carcinoma, Lung, Non-Small-Cell" 28253725 Predicative values of serum microRNA-22 and microRNA-126 levels for non-small cell lung cancer development and metastasis: a case-control study. -circulation_biomarker_diagnosis_ns hsa-mir-22 "Carcinoma, Lung, Non-Small-Cell" 28253725 Predicative values of serum microRNA-22 and microRNA-126 levels for non-small cell lung cancer development and metastasis: a case-control study. -circulation_biomarker_diagnosis_ns hsa-mir-144 "Diabetes Mellitus, Type 2" 28260062 Serum microRNA profiling and bioinformatics analysis of patients with type 2 diabetes mellitus in a Chinese population. -circulation_biomarker_diagnosis_ns hsa-mir-409 "Diabetes Mellitus, Type 2" 28260062 Serum microRNA profiling and bioinformatics analysis of patients with type 2 diabetes mellitus in a Chinese population. -circulation_biomarker_diagnosis_ns hsa-mir-454 "Diabetes Mellitus, Type 2" 28260062 Serum microRNA profiling and bioinformatics analysis of patients with type 2 diabetes mellitus in a Chinese population. -circulation_biomarker_diagnosis_ns hsa-mir-455 "Diabetes Mellitus, Type 2" 28260062 Serum microRNA profiling and bioinformatics analysis of patients with type 2 diabetes mellitus in a Chinese population. -circulation_biomarker_diagnosis_ns hsa-mir-665 "Diabetes Mellitus, Type 2" 28260062 Serum microRNA profiling and bioinformatics analysis of patients with type 2 diabetes mellitus in a Chinese population. -circulation_biomarker_diagnosis_ns hsa-mir-766 "Diabetes Mellitus, Type 2" 28260062 Serum microRNA profiling and bioinformatics analysis of patients with type 2 diabetes mellitus in a Chinese population. -circulation_biomarker_diagnosis_ns hsa-mir-96 "Diabetes Mellitus, Type 2" 28260062 Serum microRNA profiling and bioinformatics analysis of patients with type 2 diabetes mellitus in a Chinese population. -circulation_biomarker_diagnosis_ns hsa-mir-208b Acute Myocardial Infarction 28272696 A meta-analysis of the relations between blood microRNA-208b detection and acute myocardial infarction. -circulation_biomarker_diagnosis_ns hsa-mir-141 "Carcinoma, Thyroid, Papillary" 28288173 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-200a "Carcinoma, Thyroid, Papillary" 28288173 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-132 Mesothelioma 28321148 Circulating miR-132-3p as a Candidate Diagnostic Biomarker for Malignant Mesothelioma. -circulation_biomarker_diagnosis_ns hsa-mir-124 Acute Myocardial Infarction 28338188 Implication of peripheral blood miRNA-124 in predicting acute myocardial infarction. -circulation_biomarker_diagnosis_ns hsa-mir-182 "Carcinoma, Breast" 28359916 Identification of microRNA biomarkers in the blood of breast cancer patients based on microRNA profiling. -circulation_biomarker_diagnosis_ns hsa-mir-30b "Carcinoma, Breast" 28359916 Identification of microRNA biomarkers in the blood of breast cancer patients based on microRNA profiling. -circulation_biomarker_diagnosis_ns hsa-mir-374b "Carcinoma, Breast" 28359916 Identification of microRNA biomarkers in the blood of breast cancer patients based on microRNA profiling. -circulation_biomarker_diagnosis_ns hsa-mir-942 "Carcinoma, Breast" 28359916 Identification of microRNA biomarkers in the blood of breast cancer patients based on microRNA profiling. -circulation_biomarker_diagnosis_ns hsa-mir-96 "Carcinoma, Breast" 28359916 Identification of microRNA biomarkers in the blood of breast cancer patients based on microRNA profiling. -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Colon" 28376502 Circulating Exosomal MicroRNA-21 as a Biomarker in Each Tumor Stage of Colorectal Cancer. -circulation_biomarker_diagnosis_ns hsa-mir-126 Cardiovascular Diseases [unspecific] 28379027 Regulatory RNAs and cardiovascular disease - with a special focus on circulating microRNAs. -circulation_biomarker_diagnosis_ns hsa-mir-143 Cardiovascular Diseases [unspecific] 28379027 Regulatory RNAs and cardiovascular disease - with a special focus on circulating microRNAs. -circulation_biomarker_diagnosis_ns hsa-mir-145 Cardiovascular Diseases [unspecific] 28379027 Regulatory RNAs and cardiovascular disease - with a special focus on circulating microRNAs. -circulation_biomarker_diagnosis_ns hsa-mir-221 Cardiovascular Diseases [unspecific] 28379027 Regulatory RNAs and cardiovascular disease - with a special focus on circulating microRNAs. -circulation_biomarker_diagnosis_ns hsa-mir-222 Cardiovascular Diseases [unspecific] 28379027 Regulatory RNAs and cardiovascular disease - with a special focus on circulating microRNAs. -circulation_biomarker_diagnosis_ns hsa-mir-26 Cardiovascular Diseases [unspecific] 28379027 Regulatory RNAs and cardiovascular disease - with a special focus on circulating microRNAs. -circulation_biomarker_diagnosis_ns hsa-mir-33 Cardiovascular Diseases [unspecific] 28379027 Regulatory RNAs and cardiovascular disease - with a special focus on circulating microRNAs. -circulation_biomarker_diagnosis_ns hsa-mir-758 Cardiovascular Diseases [unspecific] 28379027 Regulatory RNAs and cardiovascular disease - with a special focus on circulating microRNAs. -circulation_biomarker_diagnosis_ns hsa-mir-221 Glioblastoma 28381184 "microRNA expression levels was built, which has the potential to be used in clinics and thus to improve the survival status of glioblastoma multiforme patients" -circulation_biomarker_diagnosis_ns hsa-mir-222 Glioblastoma 28381184 "microRNA expression levels was built, which has the potential to be used in clinics and thus to improve the survival status of glioblastoma multiforme patients" -circulation_biomarker_diagnosis_ns hsa-mir-134 Mesial Temporal Lobe Epilepsy 28384161 MicroRNA hsa-miR-134 is a circulating biomarker for mesial temporal lobe epilepsy. -circulation_biomarker_diagnosis_ns hsa-mir-31 Foot-and-Mouth Disease 28388926 Proof-of-concept study: profile of circulating microRNAs in Bovine serum harvested during acute and persistent FMDV infection. -circulation_biomarker_diagnosis_ns hsa-mir-20a Gastric Neoplasms 28413641 Serum miR-20a is a promising biomarker for gastric cancer. -circulation_biomarker_diagnosis_ns hsa-let-7g Colon Neoplasms 28415718 Exosomal microRNAs isolated from plasma of mesenteric veins linked to liver metastases in resected patients with colon cancer. -circulation_biomarker_diagnosis_ns hsa-mir-155 Colon Neoplasms 28415718 Exosomal microRNAs isolated from plasma of mesenteric veins linked to liver metastases in resected patients with colon cancer. -circulation_biomarker_diagnosis_ns hsa-mir-126 "Aortic Aneurysm, Abdominal" 28425970 Aneurysm-Specific miR-221 and miR-146a Participates in Human Thoracic and Abdominal Aortic Aneurysms. -circulation_biomarker_diagnosis_ns hsa-mir-145 "Aortic Aneurysm, Abdominal" 28425970 Aneurysm-Specific miR-221 and miR-146a Participates in Human Thoracic and Abdominal Aortic Aneurysms. -circulation_biomarker_diagnosis_ns hsa-mir-361 Essential Hypertension 28445253 micro-RNA screening and prediction model construction for diagnosis of salt-sensitive essential hypertension. -circulation_biomarker_diagnosis_ns hsa-mir-362 Essential Hypertension 28445253 micro-RNA screening and prediction model construction for diagnosis of salt-sensitive essential hypertension. -circulation_biomarker_diagnosis_ns hsa-mir-16 Multiple Myeloma 28446295 Circulating Serum MicroRNA as Diagnostic Biomarkers for Multiple Myeloma. -circulation_biomarker_diagnosis_ns hsa-mir-375 "Adenocarcinoma, Lung" 28449331 miR-130A as a diagnostic marker to differentiate malignant mesothelioma from lung adenocarcinoma in pleural effusion cytology. -circulation_biomarker_diagnosis_ns hsa-mir-196a Pancreatic Adenocarcinoma 28466015 "Evaluation of Plasma MicroRNAs as Diagnostic and Prognostic Biomarkers in Pancreatic Adenocarcinoma: miR-196a and miR-210 Could Be Negative and Positive Prognostic Markers, Respectively." -circulation_biomarker_diagnosis_ns hsa-mir-210 Pancreatic Adenocarcinoma 28466015 "Evaluation of Plasma MicroRNAs as Diagnostic and Prognostic Biomarkers in Pancreatic Adenocarcinoma: miR-196a and miR-210 Could Be Negative and Positive Prognostic Markers, Respectively." -circulation_biomarker_diagnosis_ns hsa-mir-149 Cutaneous Melanoma 28466785 Identification of plasma microRNAs as new potential biomarkers with high diagnostic power in human cutaneous melanoma. -circulation_biomarker_diagnosis_ns hsa-mir-150 Cutaneous Melanoma 28466785 Identification of plasma microRNAs as new potential biomarkers with high diagnostic power in human cutaneous melanoma. -circulation_biomarker_diagnosis_ns hsa-mir-15b Cutaneous Melanoma 28466785 Identification of plasma microRNAs as new potential biomarkers with high diagnostic power in human cutaneous melanoma. -circulation_biomarker_diagnosis_ns hsa-mir-193a Cutaneous Melanoma 28466785 Identification of plasma microRNAs as new potential biomarkers with high diagnostic power in human cutaneous melanoma. -circulation_biomarker_diagnosis_ns hsa-mir-524 Cutaneous Melanoma 28466785 Identification of plasma microRNAs as new potential biomarkers with high diagnostic power in human cutaneous melanoma. -circulation_biomarker_diagnosis_ns hsa-mir-873 Ectopic Pregnancy 28472791 MicroRNA-873 is a Potential Serum Biomarker for the Detection of Ectopic Pregnancy. -circulation_biomarker_diagnosis_ns hsa-mir-1825 Glioma 28475008 A novel serum microRNA-based identification and classification biomarker of human glioma. -circulation_biomarker_diagnosis_ns hsa-mir-27a Heart Failure 28475616 Rodent heart failure models do not reflect the human circulating microRNA signature in heart failure. -circulation_biomarker_diagnosis_ns hsa-mir-125b Kidney Diseases [unspecific] 28522697 Circulating MicroRNA-125b Predicts the Presence and Progression of Uremic Vascular Calcification. -circulation_biomarker_diagnosis_ns hsa-mir-146a Sepsis 28552958 Characterization of basal and lipopolysaccharide-induced microRNA expression in equine peripheral blood mononuclear cells using Next-Generation Sequencing. -circulation_biomarker_diagnosis_ns hsa-mir-155 Sepsis 28552958 Characterization of basal and lipopolysaccharide-induced microRNA expression in equine peripheral blood mononuclear cells using Next-Generation Sequencing. -circulation_biomarker_diagnosis_ns hsa-mir-206 Pulmonary Hypertension 28554172 The Circulating MicroRNA-206 Level Predicts the Severity of Pulmonary Hypertension in Patients with Left Heart Diseases. -circulation_biomarker_diagnosis_ns hsa-mir-210 Rheumatoid Arthritis 28560518 miR-210 expression in PBMCs from patients with systemic lupus erythematosus and rheumatoid arthritis. -circulation_biomarker_diagnosis_ns hsa-mir-210 Systemic Lupus Erythematosus 28560518 miR-210 expression in PBMCs from patients with systemic lupus erythematosus and rheumatoid arthritis. -circulation_biomarker_diagnosis_ns hsa-mir-182 Chronic Hepatitis B 28562750 Circulating microRNA as a marker for predicting liver disease progression in patients with chronic hepatitis B. -circulation_biomarker_diagnosis_ns hsa-mir-125a Kideny Transplant Rejection 28577875 "Circulating miR-150, miR-192, miR-200b, and miR-423-3p as Non-invasive Biomarkers of Chronic Allograft Dysfunction." -circulation_biomarker_diagnosis_ns hsa-mir-150 Kideny Transplant Rejection 28577875 "Circulating miR-150, miR-192, miR-200b, and miR-423-3p as Non-invasive Biomarkers of Chronic Allograft Dysfunction." -circulation_biomarker_diagnosis_ns hsa-mir-192 Kideny Transplant Rejection 28577875 "Circulating miR-150, miR-192, miR-200b, and miR-423-3p as Non-invasive Biomarkers of Chronic Allograft Dysfunction." -circulation_biomarker_diagnosis_ns hsa-mir-200b Kideny Transplant Rejection 28577875 "Circulating miR-150, miR-192, miR-200b, and miR-423-3p as Non-invasive Biomarkers of Chronic Allograft Dysfunction." -circulation_biomarker_diagnosis_ns hsa-mir-423 Kideny Transplant Rejection 28577875 "Circulating miR-150, miR-192, miR-200b, and miR-423-3p as Non-invasive Biomarkers of Chronic Allograft Dysfunction." -circulation_biomarker_diagnosis_ns hsa-mir-499 Myocardial Infarction 28614255 miRNA-499 had better diagnostic accuracy over other miRNAs -circulation_biomarker_diagnosis_ns hsa-mir-130a Coronary Artery Disease 28628920 "Predictive Effects of Circulating miR-221, miR-130a and miR-155 for Coronary Heart Disease: A Multi-Ethnic Study in China." -circulation_biomarker_diagnosis_ns hsa-mir-155 Coronary Artery Disease 28628920 "Predictive Effects of Circulating miR-221, miR-130a and miR-155 for Coronary Heart Disease: A Multi-Ethnic Study in China." -circulation_biomarker_diagnosis_ns hsa-mir-221 Coronary Artery Disease 28628920 "Predictive Effects of Circulating miR-221, miR-130a and miR-155 for Coronary Heart Disease: A Multi-Ethnic Study in China." -circulation_biomarker_diagnosis_ns hsa-mir-143 Hyperhomocysteinemia 28633641 Expression levels of atherosclerosis-associated miR-143 and miR-145 in the plasma of patients with hyperhomocysteinaemia. -circulation_biomarker_diagnosis_ns hsa-mir-145 Hyperhomocysteinemia 28633641 Expression levels of atherosclerosis-associated miR-143 and miR-145 in the plasma of patients with hyperhomocysteinaemia. -circulation_biomarker_diagnosis_ns hsa-mir-16 "Carcinoma, Lung, Non-Small-Cell" 28634901 "Changes in plasma miR-9, miR-16, miR-205 and miR-486 levels after non-small cell lung cancer resection." -circulation_biomarker_diagnosis_ns hsa-mir-205 "Carcinoma, Lung, Non-Small-Cell" 28634901 "Changes in plasma miR-9, miR-16, miR-205 and miR-486 levels after non-small cell lung cancer resection." -circulation_biomarker_diagnosis_ns hsa-mir-375 Neoplasms [unspecific] 28638226 Validation of a serum microRNA panel as biomarkers for early diagnosis of hepatocellular carcinoma post-hepatitis C infection in Egyptian patients. -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Gastric" 28641313 Evaluation of serum microRNA biomarkers for gastric cancer based on blood and tissue pools profiling: the importance of miR-21 and miR-331. -circulation_biomarker_diagnosis_ns hsa-mir-331 "Carcinoma, Gastric" 28641313 Evaluation of serum microRNA biomarkers for gastric cancer based on blood and tissue pools profiling: the importance of miR-21 and miR-331. -circulation_biomarker_diagnosis_ns hsa-mir-146a Osteoarthritis 28647559 "miRNA-146a, miRNA-155 and JNK expression levels in peripheral blood mononuclear cells according to grade of knee osteoarthritis." -circulation_biomarker_diagnosis_ns hsa-mir-155 Osteoarthritis 28647559 "miRNA-146a, miRNA-155 and JNK expression levels in peripheral blood mononuclear cells according to grade of knee osteoarthritis." -circulation_biomarker_diagnosis_ns hsa-mir-1 Myocardial Infarction 28663047 Diagnostic and prognostic value of miR-1 and miR-29b on adverse ventricular remodeling after acute myocardial infarction -circulation_biomarker_diagnosis_ns hsa-mir-29b Myocardial Infarction 28663047 Diagnostic and prognostic value of miR-1 and miR-29b on adverse ventricular remodeling after acute myocardial infarction -circulation_biomarker_diagnosis_ns hsa-mir-133a Heart Failure 28666417 Identifying differential miR and gene consensus patterns in peripheral blood of patients with cardiovascular diseases from literature data. -circulation_biomarker_diagnosis_ns hsa-mir-155 Preeclampsia 28700503 MiR-210 and miR-155 as potential diagnostic markers for pre-eclampsia pregnancies. -circulation_biomarker_diagnosis_ns hsa-mir-210 Preeclampsia 28700503 MiR-210 and miR-155 as potential diagnostic markers for pre-eclampsia pregnancies. -circulation_biomarker_diagnosis_ns hsa-mir-21 Osteosarcoma 28742209 The expression significance of serum MiR-21 in patients with osteosarcoma and its relationship with chemosensitivity. -circulation_biomarker_diagnosis_ns hsa-mir-122 "Carcinoma, Hepatocellular" 28750770 Circulating microRNAs panel as a diagnostic tool for discrimination of HCV-associated hepatocellular carcinoma -circulation_biomarker_diagnosis_ns hsa-mir-122 Ischemic Heart Disease 28768728 "six miRNA mimics (miR-34a, -122, -133a, -142, -146a, and -208a) induced cytokine production in a dose-dependent manner" -circulation_biomarker_diagnosis_ns hsa-mir-133a Ischemic Heart Disease 28768728 "six miRNA mimics (miR-34a, -122, -133a, -142, -146a, and -208a) induced cytokine production in a dose-dependent manner" -circulation_biomarker_diagnosis_ns hsa-mir-142 Ischemic Heart Disease 28768728 "six miRNA mimics (miR-34a, -122, -133a, -142, -146a, and -208a) induced cytokine production in a dose-dependent manner" -circulation_biomarker_diagnosis_ns hsa-mir-146a Ischemic Heart Disease 28768728 "six miRNA mimics (miR-34a, -122, -133a, -142, -146a, and -208a) induced cytokine production in a dose-dependent manner" -circulation_biomarker_diagnosis_ns hsa-mir-208a Ischemic Heart Disease 28768728 "six miRNA mimics (miR-34a, -122, -133a, -142, -146a, and -208a) induced cytokine production in a dose-dependent manner" -circulation_biomarker_diagnosis_ns hsa-mir-34a Ischemic Heart Disease 28768728 "six miRNA mimics (miR-34a, -122, -133a, -142, -146a, and -208a) induced cytokine production in a dose-dependent manner" -circulation_biomarker_diagnosis_ns hsa-mir-155 Rheumatoid Arthritis 28782994 Serum miR-210 and miR-155 expression levels as novel biomarkers for rheumatoid arthritis diagnosis. -circulation_biomarker_diagnosis_ns hsa-mir-210 Rheumatoid Arthritis 28782994 Serum miR-210 and miR-155 expression levels as novel biomarkers for rheumatoid arthritis diagnosis. -circulation_biomarker_diagnosis_ns hsa-mir-33a Hyperlipoproteinemia Type III 28811385 Circulating miR-200c is up-regulated in paediatric patients with familial hypercholesterolaemia and correlates with miR-33a/b levels: implication of a ZEB1-dependent mechanism. -circulation_biomarker_diagnosis_ns hsa-mir-33b Hyperlipoproteinemia Type III 28811385 Circulating miR-200c is up-regulated in paediatric patients with familial hypercholesterolaemia and correlates with miR-33a/b levels: implication of a ZEB1-dependent mechanism. -circulation_biomarker_diagnosis_ns hsa-mir-454 Glioma 28815332 "A signature composed of miR-93, miR-590-3p, and miR-454 enabled to nearly perfectly separate patients from controls" -circulation_biomarker_diagnosis_ns hsa-mir-590 Glioma 28815332 "A signature composed of miR-93, miR-590-3p, and miR-454 enabled to nearly perfectly separate patients from controls" -circulation_biomarker_diagnosis_ns hsa-mir-93 Glioma 28815332 "A signature composed of miR-93, miR-590-3p, and miR-454 enabled to nearly perfectly separate patients from controls" -circulation_biomarker_diagnosis_ns hsa-mir-181a "Leukemia, Lymphocytic, Chronic, B-Cell" 28830603 Comparison of microRNA expression in high-count monoclonal B-cell lymphocytosis and Binet A chronic lymphocytic leukemia -circulation_biomarker_diagnosis_ns hsa-mir-181a Acute Respiratory Distress Syndrome 28856588 "miR-181a and miR-92a are risk biomarkers for ARDS, whereas miR-424 is a protective biomarker" -circulation_biomarker_diagnosis_ns hsa-mir-424 Acute Respiratory Distress Syndrome 28856588 "miR-181a and miR-92a are risk biomarkers for ARDS, whereas miR-424 is a protective biomarker" -circulation_biomarker_diagnosis_ns hsa-mir-92a Acute Respiratory Distress Syndrome 28856588 "miR-181a and miR-92a are risk biomarkers for ARDS, whereas miR-424 is a protective biomarker" -circulation_biomarker_diagnosis_ns hsa-mir-146a Peripheral Nervous System Diseases 28870579 Aberrant microRNA expression in patients with painful peripheral neuropathies. -circulation_biomarker_diagnosis_ns hsa-mir-155 Peripheral Nervous System Diseases 28870579 Aberrant microRNA expression in patients with painful peripheral neuropathies. -circulation_biomarker_diagnosis_ns hsa-mir-21 Peripheral Nervous System Diseases 28870579 Aberrant microRNA expression in patients with painful peripheral neuropathies. -circulation_biomarker_diagnosis_ns hsa-mir-9 Schizophrenia 28877483 Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells. -circulation_biomarker_diagnosis_ns hsa-mir-449a Celiac Disease 28878141 Intestinal and Circulating MicroRNAs in Coeliac Disease. -circulation_biomarker_diagnosis_ns hsa-mir-23a "Carcinoma, Hepatocellular" 28878865 MicroRNA 23a can be used as a screening test for early detection of HCC -circulation_biomarker_diagnosis_ns hsa-mir-143 "Leukemia, Myeloid, Acute" 28890884 "Circulating miR-92a, miR-143 and miR-342 in Plasma are Novel Potential Biomarkers for Acute Myeloid Leukemia" -circulation_biomarker_diagnosis_ns hsa-mir-342 "Leukemia, Myeloid, Acute" 28890884 "Circulating miR-92a, miR-143 and miR-342 in Plasma are Novel Potential Biomarkers for Acute Myeloid Leukemia" -circulation_biomarker_diagnosis_ns hsa-mir-92a "Leukemia, Myeloid, Acute" 28890884 "Circulating miR-92a, miR-143 and miR-342 in Plasma are Novel Potential Biomarkers for Acute Myeloid Leukemia" -circulation_biomarker_diagnosis_ns hsa-mir-155 Cervical Neoplasms 28934937 "MiR-9, miR-21, and miR-155 as potential biomarkers for HPV positive and negative cervical cancer" -circulation_biomarker_diagnosis_ns hsa-mir-21 Cervical Neoplasms 28934937 "MiR-9, miR-21, and miR-155 as potential biomarkers for HPV positive and negative cervical cancer" -circulation_biomarker_diagnosis_ns hsa-mir-9 Cervical Neoplasms 28934937 "MiR-9, miR-21, and miR-155 as potential biomarkers for HPV positive and negative cervical cancer" -circulation_biomarker_diagnosis_ns hsa-mir-21 Human Immunodeficiency Virus Infection 28955339 Deregulated MicroRNA-21 Expression in Monocytes from HIV-Infected Patients Contributes to Elevated IP-10 Secretion in HIV Infection. -circulation_biomarker_diagnosis_ns hsa-mir-100 "Diabetes Mellitus, Type 1" 28986402 "Regarding circulating miRNAs, 11 were consistently dysregulated in T1DM patients compared to controls: miR-21-5p, miR-24-3p, miR-100-5p, miR-146a-5p, miR-148a-3p, miR-150-5p, miR-181a-5p, miR-210-5p, miR-342-3p, miR-375 and miR-1275" -circulation_biomarker_diagnosis_ns hsa-mir-1275 "Diabetes Mellitus, Type 1" 28986402 "Regarding circulating miRNAs, 11 were consistently dysregulated in T1DM patients compared to controls: miR-21-5p, miR-24-3p, miR-100-5p, miR-146a-5p, miR-148a-3p, miR-150-5p, miR-181a-5p, miR-210-5p, miR-342-3p, miR-375 and miR-1275" -circulation_biomarker_diagnosis_ns hsa-mir-146a "Diabetes Mellitus, Type 1" 28986402 "Regarding circulating miRNAs, 11 were consistently dysregulated in T1DM patients compared to controls: miR-21-5p, miR-24-3p, miR-100-5p, miR-146a-5p, miR-148a-3p, miR-150-5p, miR-181a-5p, miR-210-5p, miR-342-3p, miR-375 and miR-1275" -circulation_biomarker_diagnosis_ns hsa-mir-148a "Diabetes Mellitus, Type 1" 28986402 "Regarding circulating miRNAs, 11 were consistently dysregulated in T1DM patients compared to controls: miR-21-5p, miR-24-3p, miR-100-5p, miR-146a-5p, miR-148a-3p, miR-150-5p, miR-181a-5p, miR-210-5p, miR-342-3p, miR-375 and miR-1275" -circulation_biomarker_diagnosis_ns hsa-mir-150 "Diabetes Mellitus, Type 1" 28986402 "Regarding circulating miRNAs, 11 were consistently dysregulated in T1DM patients compared to controls: miR-21-5p, miR-24-3p, miR-100-5p, miR-146a-5p, miR-148a-3p, miR-150-5p, miR-181a-5p, miR-210-5p, miR-342-3p, miR-375 and miR-1275" -circulation_biomarker_diagnosis_ns hsa-mir-181a "Diabetes Mellitus, Type 1" 28986402 "Regarding circulating miRNAs, 11 were consistently dysregulated in T1DM patients compared to controls: miR-21-5p, miR-24-3p, miR-100-5p, miR-146a-5p, miR-148a-3p, miR-150-5p, miR-181a-5p, miR-210-5p, miR-342-3p, miR-375 and miR-1275" -circulation_biomarker_diagnosis_ns hsa-mir-21 "Diabetes Mellitus, Type 1" 28986402 "Regarding circulating miRNAs, 11 were consistently dysregulated in T1DM patients compared to controls: miR-21-5p, miR-24-3p, miR-100-5p, miR-146a-5p, miR-148a-3p, miR-150-5p, miR-181a-5p, miR-210-5p, miR-342-3p, miR-375 and miR-1275" -circulation_biomarker_diagnosis_ns hsa-mir-210 "Diabetes Mellitus, Type 1" 28986402 "Regarding circulating miRNAs, 11 were consistently dysregulated in T1DM patients compared to controls: miR-21-5p, miR-24-3p, miR-100-5p, miR-146a-5p, miR-148a-3p, miR-150-5p, miR-181a-5p, miR-210-5p, miR-342-3p, miR-375 and miR-1275" -circulation_biomarker_diagnosis_ns hsa-mir-24 "Diabetes Mellitus, Type 1" 28986402 "Regarding circulating miRNAs, 11 were consistently dysregulated in T1DM patients compared to controls: miR-21-5p, miR-24-3p, miR-100-5p, miR-146a-5p, miR-148a-3p, miR-150-5p, miR-181a-5p, miR-210-5p, miR-342-3p, miR-375 and miR-1275" -circulation_biomarker_diagnosis_ns hsa-mir-342 "Diabetes Mellitus, Type 1" 28986402 "Regarding circulating miRNAs, 11 were consistently dysregulated in T1DM patients compared to controls: miR-21-5p, miR-24-3p, miR-100-5p, miR-146a-5p, miR-148a-3p, miR-150-5p, miR-181a-5p, miR-210-5p, miR-342-3p, miR-375 and miR-1275" -circulation_biomarker_diagnosis_ns hsa-mir-375 "Diabetes Mellitus, Type 1" 28986402 "Regarding circulating miRNAs, 11 were consistently dysregulated in T1DM patients compared to controls: miR-21-5p, miR-24-3p, miR-100-5p, miR-146a-5p, miR-148a-3p, miR-150-5p, miR-181a-5p, miR-210-5p, miR-342-3p, miR-375 and miR-1275" -circulation_biomarker_diagnosis_ns hsa-mir-19b "Leukemia, Myeloid, Acute" 28987820 Transfer of multidrug resistance among acute myeloid leukemia cells via extracellular vesicles and their microRNA cargo. -circulation_biomarker_diagnosis_ns hsa-mir-483 Adrenal Cortex Neoplasms 29029450 "we demonstrated that miR483-5p absolute plasma levels in ACC patients are powerful molecular markers that may help in the follow-up of patients after surgery and chemotherapy, and contribute to more accurately classify and predict tumor progression." -circulation_biomarker_diagnosis_ns hsa-mir-1 Myocardial Infarction 29030746 Platelet microRNA for predicting acute myocardial infarction. -circulation_biomarker_diagnosis_ns hsa-mir-126 Myocardial Infarction 29030746 Platelet microRNA for predicting acute myocardial infarction. -circulation_biomarker_diagnosis_ns hsa-mir-150 Myocardial Infarction 29030746 Platelet microRNA for predicting acute myocardial infarction. -circulation_biomarker_diagnosis_ns hsa-mir-21 Myocardial Infarction 29030746 Platelet microRNA for predicting acute myocardial infarction. -circulation_biomarker_diagnosis_ns hsa-mir-181b Diabetic Cardiomyopathies 29044172 Circulating miR-19b and miR-181b are potential biomarkers for diabetic cardiomyopathy. -circulation_biomarker_diagnosis_ns hsa-mir-19b Diabetic Cardiomyopathies 29044172 Circulating miR-19b and miR-181b are potential biomarkers for diabetic cardiomyopathy. -circulation_biomarker_diagnosis_ns hsa-mir-155 Hypertension 29057982 Characterization of serum miRNAs as molecular biomarkers for acute Stanford type A aortic dissection diagnosis. -circulation_biomarker_diagnosis_ns hsa-mir-19b Acute Myocardial Infarction 29085838 The miRNA Expression Profile in Acute Myocardial Infarct Using Sheep Model with Left Ventricular Assist Device Unloading. -circulation_biomarker_diagnosis_ns hsa-mir-1246 Pancreatic Neoplasms 29100367 Plasma exosome miR-196a and miR-1246 are potential indicators of localized pancreatic cancer. -circulation_biomarker_diagnosis_ns hsa-mir-196a Pancreatic Neoplasms 29100367 Plasma exosome miR-196a and miR-1246 are potential indicators of localized pancreatic cancer. -circulation_biomarker_diagnosis_ns hsa-mir-21 "Adenocarcinoma, Lung" 29103767 Circulating microRNA-339-5p and -21 in plasma as an early detection predictors of lung adenocarcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-339 "Adenocarcinoma, Lung" 29103767 Circulating microRNA-339-5p and -21 in plasma as an early detection predictors of lung adenocarcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-346 Schizophrenia 29127368 Diagnostic value of blood-derived microRNAs for schizophrenia: results of a meta-analysis and validation. -circulation_biomarker_diagnosis_ns hsa-mir-16 Transitional Cell Carcinoma 29141625 MicroRNA profiling of dogs with transitional cell carcinoma of the bladder using blood and urine samples. -circulation_biomarker_diagnosis_ns hsa-mir-34a Transitional Cell Carcinoma 29141625 MicroRNA profiling of dogs with transitional cell carcinoma of the bladder using blood and urine samples. -circulation_biomarker_diagnosis_ns hsa-mir-126 Hypertension 29186297 "Cardiovascular morbidity is associated with differential expression of myriad miRNAs; miR-21, miR-155, miR-126, miR-146a/b, miR-143/145, miR-223, and miR-221 are the top 9 most reported miRNAs in hypertension and atherosclerotic disease" -circulation_biomarker_diagnosis_ns hsa-mir-143 Hypertension 29186297 "Cardiovascular morbidity is associated with differential expression of myriad miRNAs; miR-21, miR-155, miR-126, miR-146a/b, miR-143/145, miR-223, and miR-221 are the top 9 most reported miRNAs in hypertension and atherosclerotic disease" -circulation_biomarker_diagnosis_ns hsa-mir-145 Hypertension 29186297 "Cardiovascular morbidity is associated with differential expression of myriad miRNAs; miR-21, miR-155, miR-126, miR-146a/b, miR-143/145, miR-223, and miR-221 are the top 9 most reported miRNAs in hypertension and atherosclerotic disease" -circulation_biomarker_diagnosis_ns hsa-mir-146a Hypertension 29186297 "Cardiovascular morbidity is associated with differential expression of myriad miRNAs; miR-21, miR-155, miR-126, miR-146a/b, miR-143/145, miR-223, and miR-221 are the top 9 most reported miRNAs in hypertension and atherosclerotic disease" -circulation_biomarker_diagnosis_ns hsa-mir-146b Hypertension 29186297 "Cardiovascular morbidity is associated with differential expression of myriad miRNAs; miR-21, miR-155, miR-126, miR-146a/b, miR-143/145, miR-223, and miR-221 are the top 9 most reported miRNAs in hypertension and atherosclerotic disease" -circulation_biomarker_diagnosis_ns hsa-mir-155 Hypertension 29186297 "Cardiovascular morbidity is associated with differential expression of myriad miRNAs; miR-21, miR-155, miR-126, miR-146a/b, miR-143/145, miR-223, and miR-221 are the top 9 most reported miRNAs in hypertension and atherosclerotic disease" -circulation_biomarker_diagnosis_ns hsa-mir-21 Hypertension 29186297 "Cardiovascular morbidity is associated with differential expression of myriad miRNAs; miR-21, miR-155, miR-126, miR-146a/b, miR-143/145, miR-223, and miR-221 are the top 9 most reported miRNAs in hypertension and atherosclerotic disease" -circulation_biomarker_diagnosis_ns hsa-mir-221 Hypertension 29186297 "Cardiovascular morbidity is associated with differential expression of myriad miRNAs; miR-21, miR-155, miR-126, miR-146a/b, miR-143/145, miR-223, and miR-221 are the top 9 most reported miRNAs in hypertension and atherosclerotic disease" -circulation_biomarker_diagnosis_ns hsa-mir-223 Hypertension 29186297 "Cardiovascular morbidity is associated with differential expression of myriad miRNAs; miR-21, miR-155, miR-126, miR-146a/b, miR-143/145, miR-223, and miR-221 are the top 9 most reported miRNAs in hypertension and atherosclerotic disease" -circulation_biomarker_diagnosis_ns hsa-mir-21 Myocardial Infarction 29188800 Chip-based digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction patients -circulation_biomarker_diagnosis_ns hsa-mir-499 Myocardial Infarction 29188800 Chip-based digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction patients -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Hepatocellular" 29215815 "Combination of plasma miRNA-21, -26a, and -29a-3p expression could predict early TACE refractoriness in patients with TACE-treated HCC" -circulation_biomarker_diagnosis_ns hsa-mir-26a "Carcinoma, Hepatocellular" 29215815 "Combination of plasma miRNA-21, -26a, and -29a-3p expression could predict early TACE refractoriness in patients with TACE-treated HCC" -circulation_biomarker_diagnosis_ns hsa-mir-29a "Carcinoma, Hepatocellular" 29215815 "Combination of plasma miRNA-21, -26a, and -29a-3p expression could predict early TACE refractoriness in patients with TACE-treated HCC" -circulation_biomarker_diagnosis_ns hsa-mir-145 Multiple Sclerosis 29246612 "miR-145, miR-223 and miR-326 expression profile is a promising diagnostic biomarker for MS and NPSLE, but not for NMOSD" -circulation_biomarker_diagnosis_ns hsa-mir-145 Systemic Lupus Erythematosus 29246612 "miR-145, miR-223 and miR-326 expression profile is a promising diagnostic biomarker for MS and NPSLE, but not for NMOSD" -circulation_biomarker_diagnosis_ns hsa-mir-223 Multiple Sclerosis 29246612 "miR-145, miR-223 and miR-326 expression profile is a promising diagnostic biomarker for MS and NPSLE, but not for NMOSD" -circulation_biomarker_diagnosis_ns hsa-mir-223 Systemic Lupus Erythematosus 29246612 "miR-145, miR-223 and miR-326 expression profile is a promising diagnostic biomarker for MS and NPSLE, but not for NMOSD" -circulation_biomarker_diagnosis_ns hsa-mir-326 Multiple Sclerosis 29246612 "miR-145, miR-223 and miR-326 expression profile is a promising diagnostic biomarker for MS and NPSLE, but not for NMOSD" -circulation_biomarker_diagnosis_ns hsa-mir-326 Systemic Lupus Erythematosus 29246612 "miR-145, miR-223 and miR-326 expression profile is a promising diagnostic biomarker for MS and NPSLE, but not for NMOSD" -circulation_biomarker_diagnosis_ns hsa-mir-223 Prostate Neoplasms 29246734 "A 3-miR (miRNA-223, miRNA-24 and miRNA-375) score was significant to predict patient reclassification" -circulation_biomarker_diagnosis_ns hsa-mir-24 Prostate Neoplasms 29246734 "A 3-miR (miRNA-223, miRNA-24 and miRNA-375) score was significant to predict patient reclassification" -circulation_biomarker_diagnosis_ns hsa-mir-375 Prostate Neoplasms 29246734 "A 3-miR (miRNA-223, miRNA-24 and miRNA-375) score was significant to predict patient reclassification" -circulation_biomarker_diagnosis_ns hsa-mir-146a Heart Failure 29258606 Inflammation-associated microRNA changes in circulating exosomes of heart failure patients -circulation_biomarker_diagnosis_ns hsa-mir-16 Heart Failure 29258606 Inflammation-associated microRNA changes in circulating exosomes of heart failure patients -circulation_biomarker_diagnosis_ns hsa-mir-1233 "Carcinoma, Renal Cell" 29262564 "Plasmatic miR-210, miR-221 and miR-1233 profile: potential liquid biopsies candidates for renal cell carcinoma" -circulation_biomarker_diagnosis_ns hsa-mir-210 "Carcinoma, Renal Cell" 29262564 "Plasmatic miR-210, miR-221 and miR-1233 profile: potential liquid biopsies candidates for renal cell carcinoma" -circulation_biomarker_diagnosis_ns hsa-mir-221 "Carcinoma, Renal Cell" 29262564 "Plasmatic miR-210, miR-221 and miR-1233 profile: potential liquid biopsies candidates for renal cell carcinoma" -circulation_biomarker_diagnosis_ns hsa-mir-598 Crohn Colitis 29272478 "Two miRNAs (miR-598, miR-642) were consistently different between the patient groups" -circulation_biomarker_diagnosis_ns hsa-mir-642 Crohn Colitis 29272478 "Two miRNAs (miR-598, miR-642) were consistently different between the patient groups" -circulation_biomarker_diagnosis_ns hsa-mir-145 Endometriosis 29308623 miR-31 and miR-145 as Potential Non-Invasive Regulatory Biomarkers in Patients with Endometriosis -circulation_biomarker_diagnosis_ns hsa-mir-31 Endometriosis 29308623 miR-31 and miR-145 as Potential Non-Invasive Regulatory Biomarkers in Patients with Endometriosis -circulation_biomarker_diagnosis_ns hsa-mir-106b "Carcinoma, Hepatocellular" 29312570 Serum microRNA signatures and metabolomics have high diagnostic value in hepatocellular carcinoma -circulation_biomarker_diagnosis_ns hsa-mir-182 "Carcinoma, Hepatocellular" 29312570 Serum microRNA signatures and metabolomics have high diagnostic value in hepatocellular carcinoma -circulation_biomarker_diagnosis_ns hsa-mir-126 Heart Failure 29314582 "A differential modulation of circulating levels of miR-423, -34a, -21-3p, -126, -199 and -30a was found across the aetiology groups" -circulation_biomarker_diagnosis_ns hsa-mir-199 Heart Failure 29314582 "A differential modulation of circulating levels of miR-423, -34a, -21-3p, -126, -199 and -30a was found across the aetiology groups" -circulation_biomarker_diagnosis_ns hsa-mir-21 Heart Failure 29314582 "A differential modulation of circulating levels of miR-423, -34a, -21-3p, -126, -199 and -30a was found across the aetiology groups" -circulation_biomarker_diagnosis_ns hsa-mir-30a Heart Failure 29314582 "A differential modulation of circulating levels of miR-423, -34a, -21-3p, -126, -199 and -30a was found across the aetiology groups" -circulation_biomarker_diagnosis_ns hsa-mir-34a Heart Failure 29314582 "A differential modulation of circulating levels of miR-423, -34a, -21-3p, -126, -199 and -30a was found across the aetiology groups" -circulation_biomarker_diagnosis_ns hsa-mir-423 Heart Failure 29314582 "A differential modulation of circulating levels of miR-423, -34a, -21-3p, -126, -199 and -30a was found across the aetiology groups" -circulation_biomarker_diagnosis_ns hsa-mir-125a "Carcinoma, Hepatocellular" 29333940 "the measurement of serum levels of miR-125a, miR-139, miR-145, and miR-199a can help to differentiate HCC from CHC and LC" -circulation_biomarker_diagnosis_ns hsa-mir-139 "Carcinoma, Hepatocellular" 29333940 "the measurement of serum levels of miR-125a, miR-139, miR-145, and miR-200a can help to differentiate HCC from CHC and LC" -circulation_biomarker_diagnosis_ns hsa-mir-145 "Carcinoma, Hepatocellular" 29333940 "the measurement of serum levels of miR-125a, miR-139, miR-145, and miR-201a can help to differentiate HCC from CHC and LC" -circulation_biomarker_diagnosis_ns hsa-mir-199a "Carcinoma, Hepatocellular" 29333940 "the measurement of serum levels of miR-125a, miR-139, miR-145, and miR-202a can help to differentiate HCC from CHC and LC" -circulation_biomarker_diagnosis_ns hsa-mir-1 Acute Coronary Syndrome 29350392 "although most investigated miRs levels differ significantly between patients with ACS and CIE, similar levels of circulating miR-1-3p, miR-133a-3p, miR-133b, and miR-375 were observed; furthermore, we identified several common miRs as possible risk factors for recurrent cardiovascular events" -circulation_biomarker_diagnosis_ns hsa-mir-133a Acute Coronary Syndrome 29350392 "although most investigated miRs levels differ significantly between patients with ACS and CIE, similar levels of circulating miR-1-3p, miR-133a-3p, miR-133b, and miR-375 were observed; furthermore, we identified several common miRs as possible risk factors for recurrent cardiovascular events" -circulation_biomarker_diagnosis_ns hsa-mir-133b Acute Coronary Syndrome 29350392 "although most investigated miRs levels differ significantly between patients with ACS and CIE, similar levels of circulating miR-1-3p, miR-133a-3p, miR-133b, and miR-375 were observed; furthermore, we identified several common miRs as possible risk factors for recurrent cardiovascular events" -circulation_biomarker_diagnosis_ns hsa-mir-375 Acute Coronary Syndrome 29350392 "although most investigated miRs levels differ significantly between patients with ACS and CIE, similar levels of circulating miR-1-3p, miR-133a-3p, miR-133b, and miR-375 were observed; furthermore, we identified several common miRs as possible risk factors for recurrent cardiovascular events" -circulation_biomarker_diagnosis_ns hsa-mir-146a Coronary Artery Disease 29357324 Circulating MiR-146a May be a Potential Biomarker of Coronary Heart Disease in Patients with Subclinical Hypothyroidism. -circulation_biomarker_diagnosis_ns hsa-mir-375 "Diabetes Mellitus, Type 2" 29373500 Evaluation of Two-Diabetes Related microRNAs Suitability as Earlier Blood Biomarkers for Detecting Prediabetes and type 2 Diabetes Mellitus -circulation_biomarker_diagnosis_ns hsa-mir-155 Coronary Artery Disease 29411649 serum miR-155 content may serve as a novel biomarker for evaluating severity of CHD -circulation_biomarker_diagnosis_ns hsa-mir-126 Diabetes Mellitus 29452547 Plasma miR-126 and miR-210 levels may be biomarkers for diabetes with or without CAD -circulation_biomarker_diagnosis_ns hsa-mir-106a Bicuspid Aortic Valve Disease 29462317 Expression of circulating miR-17 and miR-106a in the BAV root phenotype patients correlates with the severity of aortopathy and the risk of adverse aortic events -circulation_biomarker_diagnosis_ns hsa-mir-17 Bicuspid Aortic Valve Disease 29462317 Expression of circulating miR-17 and miR-106a in the BAV root phenotype patients correlates with the severity of aortopathy and the risk of adverse aortic events -circulation_biomarker_diagnosis_ns hsa-mir-136 Amyotrophic Lateral Sclerosis 29466830 "Changes in 4 miRNAs (miR-136-3p, miR-30b-5p, miR-331-3p, miR-496) correlated positively and change in 1 miRNA (miR-2110) correlated negatively with changes in clinical parameters in longitudinal analysis" -circulation_biomarker_diagnosis_ns hsa-mir-2110 Amyotrophic Lateral Sclerosis 29466830 "Changes in 4 miRNAs (miR-136-3p, miR-30b-5p, miR-331-3p, miR-496) correlated positively and change in 1 miRNA (miR-2110) correlated negatively with changes in clinical parameters in longitudinal analysis" -circulation_biomarker_diagnosis_ns hsa-mir-30b Amyotrophic Lateral Sclerosis 29466830 "Changes in 4 miRNAs (miR-136-3p, miR-30b-5p, miR-331-3p, miR-496) correlated positively and change in 1 miRNA (miR-2110) correlated negatively with changes in clinical parameters in longitudinal analysis" -circulation_biomarker_diagnosis_ns hsa-mir-331 Amyotrophic Lateral Sclerosis 29466830 "Changes in 4 miRNAs (miR-136-3p, miR-30b-5p, miR-331-3p, miR-496) correlated positively and change in 1 miRNA (miR-2110) correlated negatively with changes in clinical parameters in longitudinal analysis" -circulation_biomarker_diagnosis_ns hsa-mir-496 Amyotrophic Lateral Sclerosis 29466830 "Changes in 4 miRNAs (miR-136-3p, miR-30b-5p, miR-331-3p, miR-496) correlated positively and change in 1 miRNA (miR-2110) correlated negatively with changes in clinical parameters in longitudinal analysis" -circulation_biomarker_diagnosis_ns hsa-mir-208b Myocardial Infarction 29475914 plasma levels of circulating miR-208b and miR-499 could serve as potential AMI biomarkers -circulation_biomarker_diagnosis_ns hsa-mir-499 Myocardial Infarction 29475914 plasma levels of circulating miR-208b and miR-500 could serve as potential AMI biomarkers -circulation_biomarker_diagnosis_ns hsa-mir-25 Heart Failure 29499204 "miR-25 expression during different stages of heart disease, offers a new perspective for the role of miR-25 function in heart failure" -circulation_biomarker_diagnosis_ns hsa-mir-128 Friedreich Ataxia 29509186 "We found different expression profiles of miRNAs (hsa-miR-128-3p, hsa-miR-625-3p, hsa-miR-130b-5p, hsa-miR-151a-5p, hsa-miR-330-3p, hsa-miR-323a-3p, and hsa-miR-142-3p) between samples from patients and samples from healthy subjects" -circulation_biomarker_diagnosis_ns hsa-mir-130b Friedreich Ataxia 29509186 "We found different expression profiles of miRNAs (hsa-miR-128-3p, hsa-miR-625-3p, hsa-miR-130b-5p, hsa-miR-151a-5p, hsa-miR-330-3p, hsa-miR-323a-3p, and hsa-miR-142-3p) between samples from patients and samples from healthy subjects" -circulation_biomarker_diagnosis_ns hsa-mir-142 Friedreich Ataxia 29509186 "We found different expression profiles of miRNAs (hsa-miR-128-3p, hsa-miR-625-3p, hsa-miR-130b-5p, hsa-miR-151a-5p, hsa-miR-330-3p, hsa-miR-323a-3p, and hsa-miR-142-3p) between samples from patients and samples from healthy subjects" -circulation_biomarker_diagnosis_ns hsa-mir-151a Friedreich Ataxia 29509186 "We found different expression profiles of miRNAs (hsa-miR-128-3p, hsa-miR-625-3p, hsa-miR-130b-5p, hsa-miR-151a-5p, hsa-miR-330-3p, hsa-miR-323a-3p, and hsa-miR-142-3p) between samples from patients and samples from healthy subjects" -circulation_biomarker_diagnosis_ns hsa-mir-323a Friedreich Ataxia 29509186 "We found different expression profiles of miRNAs (hsa-miR-128-3p, hsa-miR-625-3p, hsa-miR-130b-5p, hsa-miR-151a-5p, hsa-miR-330-3p, hsa-miR-323a-3p, and hsa-miR-142-3p) between samples from patients and samples from healthy subjects" -circulation_biomarker_diagnosis_ns hsa-mir-330 Friedreich Ataxia 29509186 "We found different expression profiles of miRNAs (hsa-miR-128-3p, hsa-miR-625-3p, hsa-miR-130b-5p, hsa-miR-151a-5p, hsa-miR-330-3p, hsa-miR-323a-3p, and hsa-miR-142-3p) between samples from patients and samples from healthy subjects" -circulation_biomarker_diagnosis_ns hsa-mir-625 Friedreich Ataxia 29509186 "We found different expression profiles of miRNAs (hsa-miR-128-3p, hsa-miR-625-3p, hsa-miR-130b-5p, hsa-miR-151a-5p, hsa-miR-330-3p, hsa-miR-323a-3p, and hsa-miR-142-3p) between samples from patients and samples from healthy subjects" -circulation_biomarker_diagnosis_ns hsa-mir-146a Periodontitis 29517812 MicroRNA-146a and microRNA-155 as novel crevicular fluid biomarkers for periodontitis in non-diabetic and type 2 diabetic patients. -circulation_biomarker_diagnosis_ns hsa-mir-155 Periodontitis 29517812 MicroRNA-146a and microRNA-155 as novel crevicular fluid biomarkers for periodontitis in non-diabetic and type 2 diabetic patients. -circulation_biomarker_diagnosis_ns hsa-mir-191 "Aortic Aneurysm, Abdominal" 29518510 Expression in Whole Blood Samples of miRNA-191 and miRNA-455-3p in Patients with AAA and Their Relationship to Clinical Outcomes after Endovascular Repair. -circulation_biomarker_diagnosis_ns hsa-mir-455 "Aortic Aneurysm, Abdominal" 29518510 Expression in Whole Blood Samples of miRNA-191 and miRNA-455-3p in Patients with AAA and Their Relationship to Clinical Outcomes after Endovascular Repair. -circulation_biomarker_diagnosis_ns hsa-mir-128 Multiple Sclerosis 29527713 "Evaluation of serum miR-191-5p, miR-24-3p, miR-128-3p, and miR-376c-3 in multiple sclerosis patients." -circulation_biomarker_diagnosis_ns hsa-mir-191 Multiple Sclerosis 29527713 "Evaluation of serum miR-191-5p, miR-24-3p, miR-128-3p, and miR-376c-3 in multiple sclerosis patients." -circulation_biomarker_diagnosis_ns hsa-mir-24 Multiple Sclerosis 29527713 "Evaluation of serum miR-191-5p, miR-24-3p, miR-128-3p, and miR-376c-3 in multiple sclerosis patients." -circulation_biomarker_diagnosis_ns hsa-mir-376c Multiple Sclerosis 29527713 "Evaluation of serum miR-191-5p, miR-24-3p, miR-128-3p, and miR-376c-3 in multiple sclerosis patients." -circulation_biomarker_diagnosis_ns hsa-mir-126 Atherosclerosis 29531852 "A common microRNA profile to different atherosclerotic disease locations was identified, including deregulation of miR-21, miR-30, miR-126, and miR-221-4p" -circulation_biomarker_diagnosis_ns hsa-mir-21 Atherosclerosis 29531852 "A common microRNA profile to different atherosclerotic disease locations was identified, including deregulation of miR-21, miR-30, miR-126, and miR-221-3p" -circulation_biomarker_diagnosis_ns hsa-mir-221 Atherosclerosis 29531852 "A common microRNA profile to different atherosclerotic disease locations was identified, including deregulation of miR-21, miR-30, miR-126, and miR-221-5p" -circulation_biomarker_diagnosis_ns hsa-mir-30 Atherosclerosis 29531852 "A common microRNA profile to different atherosclerotic disease locations was identified, including deregulation of miR-21, miR-30, miR-126, and miR-221-3p" -circulation_biomarker_diagnosis_ns hsa-mir-196a Gastric Neoplasms 29535809 circulating miRNA-196a is a novel biomarker for detection of early gastric cancer and its precursor -circulation_biomarker_diagnosis_ns hsa-mir-204 Spinal Cord Injuries 29547407 "We identified 4 targeted miRNAs, including mir-204-5p, mir-519d-3p, mir-20b-5p, mir-6838-5p, which may be potential biomarkers for SCI patients" -circulation_biomarker_diagnosis_ns hsa-mir-20b Spinal Cord Injuries 29547407 "We identified 4 targeted miRNAs, including mir-204-5p, mir-519d-3p, mir-20b-5p, mir-6838-5p, which may be potential biomarkers for SCI patients" -circulation_biomarker_diagnosis_ns hsa-mir-519d Spinal Cord Injuries 29547407 "We identified 4 targeted miRNAs, including mir-204-5p, mir-519d-3p, mir-20b-5p, mir-6838-5p, which may be potential biomarkers for SCI patients" -circulation_biomarker_diagnosis_ns hsa-mir-6838 Spinal Cord Injuries 29547407 "We identified 4 targeted miRNAs, including mir-204-5p, mir-519d-3p, mir-20b-5p, mir-6838-5p, which may be potential biomarkers for SCI patients" -circulation_biomarker_diagnosis_ns hsa-mir-199a Multiple Sclerosis 29551498 "Analysis of the expression of mir-34a, mir-199a, mir-30c and mir-19a in peripheral blood CD4+T lymphocytes of relapsing-remitting multiple sclerosis patients." -circulation_biomarker_diagnosis_ns hsa-mir-19a Multiple Sclerosis 29551498 "Analysis of the expression of mir-34a, mir-199a, mir-30c and mir-19a in peripheral blood CD4+T lymphocytes of relapsing-remitting multiple sclerosis patients." -circulation_biomarker_diagnosis_ns hsa-mir-30c Multiple Sclerosis 29551498 "Analysis of the expression of mir-34a, mir-199a, mir-30c and mir-19a in peripheral blood CD4+T lymphocytes of relapsing-remitting multiple sclerosis patients." -circulation_biomarker_diagnosis_ns hsa-mir-34a Multiple Sclerosis 29551498 "Analysis of the expression of mir-34a, mir-199a, mir-30c and mir-19a in peripheral blood CD4+T lymphocytes of relapsing-remitting multiple sclerosis patients." -circulation_biomarker_diagnosis_ns hsa-mir-143 "Leukemia, Lymphoblastic, Acute, Childhood" 29556721 Clinical utility of miR-143/miR-182 levels in prognosis and risk stratification specificity of BFM-treated childhood acute lymphoblastic leukemia. -circulation_biomarker_diagnosis_ns hsa-mir-182 "Leukemia, Lymphoblastic, Acute, Childhood" 29556721 Clinical utility of miR-143/miR-182 levels in prognosis and risk stratification specificity of BFM-treated childhood acute lymphoblastic leukemia. -circulation_biomarker_diagnosis_ns hsa-mir-106a "Carcinoma, Breast" 29557526 Circulating microRNAs from the miR-106a-363 cluster on chromosome X as novel diagnostic biomarkers for breast cancer. -circulation_biomarker_diagnosis_ns hsa-mir-223 Dementia 29559383 Serum Exosomal miR-223 Serves as a Potential Diagnostic and Prognostic Biomarker for Dementia -circulation_biomarker_diagnosis_ns hsa-mir-208a Chagas Disease 29559958 Circulating Plasma MicroRNA-208a as Potential Biomarker of Chronic Indeterminate Phase of Chagas Disease -circulation_biomarker_diagnosis_ns hsa-let-7e Dengue Virus Infection 29566761 "six significantly differentially expressed miRNAs, including hsa-miR-184, hsa-let-7e-5p, hsa-miR-132-3p, hsa-miR-155-5p, and hsa-miR-1246, were chosen for RT-qPCR analysis" -circulation_biomarker_diagnosis_ns hsa-mir-1246 Dengue Virus Infection 29566761 "six significantly differentially expressed miRNAs, including hsa-miR-184, hsa-let-7e-5p, hsa-miR-132-3p, hsa-miR-155-5p, and hsa-miR-1246, were chosen for RT-qPCR analysis" -circulation_biomarker_diagnosis_ns hsa-mir-132 Dengue Virus Infection 29566761 "six significantly differentially expressed miRNAs, including hsa-miR-184, hsa-let-7e-5p, hsa-miR-132-3p, hsa-miR-155-5p, and hsa-miR-1246, were chosen for RT-qPCR analysis" -circulation_biomarker_diagnosis_ns hsa-mir-155 Dengue Virus Infection 29566761 "six significantly differentially expressed miRNAs, including hsa-miR-184, hsa-let-7e-5p, hsa-miR-132-3p, hsa-miR-155-5p, and hsa-miR-1246, were chosen for RT-qPCR analysis" -circulation_biomarker_diagnosis_ns hsa-mir-184 Dengue Virus Infection 29566761 "six significantly differentially expressed miRNAs, including hsa-miR-184, hsa-let-7e-5p, hsa-miR-132-3p, hsa-miR-155-5p, and hsa-miR-1246, were chosen for RT-qPCR analysis" -circulation_biomarker_diagnosis_ns hsa-mir-155 "Leukemia, Myeloid, Acute" 29601851 MicroRNA-155 expression and function in AML: An evolving paradigm. -circulation_biomarker_diagnosis_ns hsa-mir-33a "Diabetes Mellitus, Type 2" 29601916 B-RCA revealed circulating miR-33a/b associates with serum cholesterol in type 2 diabetes patients at high risk of ASCVD. -circulation_biomarker_diagnosis_ns hsa-mir-33b "Diabetes Mellitus, Type 2" 29601916 B-RCA revealed circulating miR-33a/b associates with serum cholesterol in type 2 diabetes patients at high risk of ASCVD. -circulation_biomarker_diagnosis_ns hsa-mir-126 Obesity 29607782 Dysregulation of circulating miRs may contribute mechanistically to the heightened inflammatory state associated with overweight and obesity -circulation_biomarker_diagnosis_ns hsa-mir-146a Obesity 29607782 Dysregulation of circulating miRs may contribute mechanistically to the heightened inflammatory state associated with overweight and obesity -circulation_biomarker_diagnosis_ns hsa-mir-150 Obesity 29607782 Dysregulation of circulating miRs may contribute mechanistically to the heightened inflammatory state associated with overweight and obesity -circulation_biomarker_diagnosis_ns hsa-mir-181b Obesity 29607782 Dysregulation of circulating miRs may contribute mechanistically to the heightened inflammatory state associated with overweight and obesity -circulation_biomarker_diagnosis_ns hsa-mir-34a Obesity 29607782 Dysregulation of circulating miRs may contribute mechanistically to the heightened inflammatory state associated with overweight and obesity -circulation_biomarker_diagnosis_ns hsa-mir-126 Hypertension 29615793 "Specifically, altered circulating expression of miR-17, miR-21, miR-34a, miR-92a, miR-126, miR-145, miR-146a, and miR-154 has been linked with the pathogenesis and progression of cardiovascular disease" -circulation_biomarker_diagnosis_ns hsa-mir-145 Hypertension 29615793 "Specifically, altered circulating expression of miR-17, miR-21, miR-34a, miR-92a, miR-126, miR-145, miR-146a, and miR-155 has been linked with the pathogenesis and progression of cardiovascular disease" -circulation_biomarker_diagnosis_ns hsa-mir-146a Hypertension 29615793 "Specifically, altered circulating expression of miR-17, miR-21, miR-34a, miR-92a, miR-126, miR-145, miR-146a, and miR-156 has been linked with the pathogenesis and progression of cardiovascular disease" -circulation_biomarker_diagnosis_ns hsa-mir-157 Hypertension 29615793 "Specifically, altered circulating expression of miR-17, miR-21, miR-34a, miR-92a, miR-126, miR-145, miR-146a, and miR-157 has been linked with the pathogenesis and progression of cardiovascular disease" -circulation_biomarker_diagnosis_ns hsa-mir-17 Hypertension 29615793 "Specifically, altered circulating expression of miR-17, miR-21, miR-34a, miR-92a, miR-126, miR-145, miR-146a, and miR-150 has been linked with the pathogenesis and progression of cardiovascular disease" -circulation_biomarker_diagnosis_ns hsa-mir-21 Hypertension 29615793 "Specifically, altered circulating expression of miR-17, miR-21, miR-34a, miR-92a, miR-126, miR-145, miR-146a, and miR-151 has been linked with the pathogenesis and progression of cardiovascular disease" -circulation_biomarker_diagnosis_ns hsa-mir-34a Hypertension 29615793 "Specifically, altered circulating expression of miR-17, miR-21, miR-34a, miR-92a, miR-126, miR-145, miR-146a, and miR-152 has been linked with the pathogenesis and progression of cardiovascular disease" -circulation_biomarker_diagnosis_ns hsa-mir-92a Hypertension 29615793 "Specifically, altered circulating expression of miR-17, miR-21, miR-34a, miR-92a, miR-126, miR-145, miR-146a, and miR-153 has been linked with the pathogenesis and progression of cardiovascular disease" -circulation_biomarker_diagnosis_ns hsa-mir-3162 Human Immunodeficiency Virus Infection 29627523 mircoRNA-3162-3p is a potential biomarker to identify new infections in HIV-1-infected patients. -circulation_biomarker_diagnosis_ns hsa-mir-200c "Leukemia, Lymphoblastic, Acute" 29630744 MicroRNA-326 and microRNA-200c: Two novel biomarkers for diagnosis and prognosis of pediatric acute lymphoblastic leukemia. -circulation_biomarker_diagnosis_ns hsa-mir-326 "Leukemia, Lymphoblastic, Acute" 29630744 MicroRNA-326 and microRNA-200c: Two novel biomarkers for diagnosis and prognosis of pediatric acute lymphoblastic leukemia. -circulation_biomarker_diagnosis_ns hsa-mir-141 Parkinson Disease 29631008 "Differential expression of miR-34a, miR-141, and miR-9 in MPP+-treated differentiated PC12 cells as a model of Parkinson's disease." -circulation_biomarker_diagnosis_ns hsa-mir-34a Parkinson Disease 29631008 "Differential expression of miR-34a, miR-141, and miR-9 in MPP+-treated differentiated PC12 cells as a model of Parkinson's disease." -circulation_biomarker_diagnosis_ns hsa-mir-9 Parkinson Disease 29631008 "Differential expression of miR-34a, miR-141, and miR-9 in MPP+-treated differentiated PC12 cells as a model of Parkinson's disease." -circulation_biomarker_diagnosis_ns hsa-mir-145 Endometriosis 29633787 miR-31 and miR-145 as Potential Non-Invasive Regulatory Biomarkers in Patients with Endometriosis -circulation_biomarker_diagnosis_ns hsa-mir-31 Endometriosis 29633787 miR-31 and miR-145 as Potential Non-Invasive Regulatory Biomarkers in Patients with Endometriosis -circulation_biomarker_diagnosis_ns hsa-mir-539 Azoospermia 29635626 a model that included miR-539-5p and miR-941 expression values is also described as being useful for predicting the presence of residual spermatogenesis in individuals with severe spermatogenic disorders with diagnostic accuracy -circulation_biomarker_diagnosis_ns hsa-mir-941 Azoospermia 29635626 a model that included miR-539-5p and miR-941 expression values is also described as being useful for predicting the presence of residual spermatogenesis in individuals with severe spermatogenic disorders with diagnostic accuracy -circulation_biomarker_diagnosis_ns hsa-mir-122 Liver Diseases [unspecific] 29636028 Comprehensive analysis of blood cells and plasma identifies tissue-specific miRNAs as potential novel circulating biomarkers -circulation_biomarker_diagnosis_ns hsa-mir-155 Inflammatory Bowel Diseases 29668922 "Target-based approach (miR-16, miR-21, miR-155, and miR-223) has been used to evaluate miRNA expression" -circulation_biomarker_diagnosis_ns hsa-mir-16 Inflammatory Bowel Diseases 29668922 "Target-based approach (miR-16, miR-21, miR-155, and miR-223) has been used to evaluate miRNA expression" -circulation_biomarker_diagnosis_ns hsa-mir-21 Inflammatory Bowel Diseases 29668922 "Target-based approach (miR-16, miR-21, miR-155, and miR-223) has been used to evaluate miRNA expression" -circulation_biomarker_diagnosis_ns hsa-mir-223 Inflammatory Bowel Diseases 29668922 "Target-based approach (miR-16, miR-21, miR-155, and miR-223) has been used to evaluate miRNA expression" -circulation_biomarker_diagnosis_ns hsa-let-7b Amyotrophic Lateral Sclerosis 29670510 "We observed significant aberrant dysregulation across our patient cohort for miR-124a, miR-206, miR-9, let-7b, and miR-638" -circulation_biomarker_diagnosis_ns hsa-mir-124a Amyotrophic Lateral Sclerosis 29670510 "We observed significant aberrant dysregulation across our patient cohort for miR-124a, miR-206, miR-9, let-7b, and miR-638" -circulation_biomarker_diagnosis_ns hsa-mir-206 Amyotrophic Lateral Sclerosis 29670510 "We observed significant aberrant dysregulation across our patient cohort for miR-124a, miR-206, miR-9, let-7b, and miR-638" -circulation_biomarker_diagnosis_ns hsa-mir-638 Amyotrophic Lateral Sclerosis 29670510 "We observed significant aberrant dysregulation across our patient cohort for miR-124a, miR-206, miR-9, let-7b, and miR-638" -circulation_biomarker_diagnosis_ns hsa-mir-9 Amyotrophic Lateral Sclerosis 29670510 "We observed significant aberrant dysregulation across our patient cohort for miR-124a, miR-206, miR-9, let-7b, and miR-638" -circulation_biomarker_diagnosis_ns hsa-mir-106a "Squamous Cell Carcinoma, Lung" 29673101 "a four-miRNA signature (miR-181a-5p, miR-21-5p, miR-106a-5p, and miR-93-5p) was identified for LSCC detection" -circulation_biomarker_diagnosis_ns hsa-mir-181a "Squamous Cell Carcinoma, Lung" 29673101 "a four-miRNA signature (miR-181a-5p, miR-21-5p, miR-106a-5p, and miR-93-5p) was identified for LSCC detection" -circulation_biomarker_diagnosis_ns hsa-mir-21 "Squamous Cell Carcinoma, Lung" 29673101 "a four-miRNA signature (miR-181a-5p, miR-21-5p, miR-106a-5p, and miR-93-5p) was identified for LSCC detection" -circulation_biomarker_diagnosis_ns hsa-mir-93 "Squamous Cell Carcinoma, Lung" 29673101 "a four-miRNA signature (miR-181a-5p, miR-21-5p, miR-106a-5p, and miR-93-5p) was identified for LSCC detection" -circulation_biomarker_diagnosis_ns hsa-let-7a Breast Neoplasms 29683112 "A panel of serum ncRNAs, including let-7a, miR-155, miR-574-5p, and MALAT1, was shown to be present in patients with breast cancer." -circulation_biomarker_diagnosis_ns hsa-mir-155 Breast Neoplasms 29683112 "A panel of serum ncRNAs, including let-7a, miR-155, miR-574-5p, and MALAT1, was shown to be present in patients with breast cancer." -circulation_biomarker_diagnosis_ns hsa-mir-574 Breast Neoplasms 29683112 "A panel of serum ncRNAs, including let-7a, miR-155, miR-574-5p, and MALAT1, was shown to be present in patients with breast cancer." -circulation_biomarker_diagnosis_ns hsa-mir-137 Schizophrenia 29684772 "Identification of miR-22-3p, miR-92a-3p, and miR-137 in peripheral blood as biomarker for schizophrenia" -circulation_biomarker_diagnosis_ns hsa-mir-22 Schizophrenia 29684772 "Identification of miR-22-3p, miR-92a-3p, and miR-137 in peripheral blood as biomarker for schizophrenia" -circulation_biomarker_diagnosis_ns hsa-mir-92a Schizophrenia 29684772 "Identification of miR-22-3p, miR-92a-3p, and miR-137 in peripheral blood as biomarker for schizophrenia" -circulation_biomarker_diagnosis_ns hsa-mir-3613 Liposarcoma 29689704 Whole blood miRNA expression analysis reveals miR-3613-3p as a potential biomarker for dedifferentiated liposarcoma. -circulation_biomarker_diagnosis_ns hsa-mir-1 Myocardial Infarction 29698386 "Following the identification of cardiac-specific microRNA miR-208a in circulation, more non-coding RNAs (miR-1, miR-499 and miR-133) have been identified as biomarkers not only for the diagnosis of AMI but also for prognosis post infarction" -circulation_biomarker_diagnosis_ns hsa-mir-133 Myocardial Infarction 29698386 "Following the identification of cardiac-specific microRNA miR-208a in circulation, more non-coding RNAs (miR-1, miR-499 and miR-133) have been identified as biomarkers not only for the diagnosis of AMI but also for prognosis post infarction" -circulation_biomarker_diagnosis_ns hsa-mir-208a Myocardial Infarction 29698386 "Following the identification of cardiac-specific microRNA miR-208a in circulation, more non-coding RNAs (miR-1, miR-499 and miR-133) have been identified as biomarkers not only for the diagnosis of AMI but also for prognosis post infarction" -circulation_biomarker_diagnosis_ns hsa-mir-499 Myocardial Infarction 29698386 "Following the identification of cardiac-specific microRNA miR-208a in circulation, more non-coding RNAs (miR-1, miR-499 and miR-133) have been identified as biomarkers not only for the diagnosis of AMI but also for prognosis post infarction" -circulation_biomarker_diagnosis_ns hsa-mir-21 "Leukemia, Lymphocytic, Chronic, B-Cell" 29730931 "specifically miR-21-5p and a 23 nucleotide long 5'-phosphorylated miRNA with 3'-uridylation (iso-miR-16-5p), were only detected in the CLL patients" -circulation_biomarker_diagnosis_ns hsa-let-7c Respiratory Syncytial Virus Pneumonia 29733865 "MicroRNA 146-5p, miR-let-7c-5p, miR-221 and miR-345-5p are differentially expressed in Respiratory Syncytial Virus (RSV) persistently infected HEp-2 cells." -circulation_biomarker_diagnosis_ns hsa-mir-146 Respiratory Syncytial Virus Pneumonia 29733865 "MicroRNA 146-5p, miR-let-7c-5p, miR-221 and miR-345-5p are differentially expressed in Respiratory Syncytial Virus (RSV) persistently infected HEp-2 cells." -circulation_biomarker_diagnosis_ns hsa-mir-221 Respiratory Syncytial Virus Pneumonia 29733865 "MicroRNA 146-5p, miR-let-7c-5p, miR-221 and miR-345-5p are differentially expressed in Respiratory Syncytial Virus (RSV) persistently infected HEp-2 cells." -circulation_biomarker_diagnosis_ns hsa-mir-345 Respiratory Syncytial Virus Pneumonia 29733865 "MicroRNA 146-5p, miR-let-7c-5p, miR-221 and miR-345-5p are differentially expressed in Respiratory Syncytial Virus (RSV) persistently infected HEp-2 cells." -circulation_biomarker_diagnosis_ns hsa-mir-146a Cerebral Malaria 29747626 "The differential expression profiles of these selected miRNA (miR-146a, miR-150, miR-193b, miR-205, miR-215, miR-467a, and miR-486) were analyzed in mouse MV" -circulation_biomarker_diagnosis_ns hsa-mir-150 Cerebral Malaria 29747626 "The differential expression profiles of these selected miRNA (miR-146a, miR-150, miR-193b, miR-205, miR-215, miR-467a, and miR-486) were analyzed in mouse MV" -circulation_biomarker_diagnosis_ns hsa-mir-193b Cerebral Malaria 29747626 "The differential expression profiles of these selected miRNA (miR-146a, miR-150, miR-193b, miR-205, miR-215, miR-467a, and miR-486) were analyzed in mouse MV" -circulation_biomarker_diagnosis_ns hsa-mir-205 Cerebral Malaria 29747626 "The differential expression profiles of these selected miRNA (miR-146a, miR-150, miR-193b, miR-205, miR-215, miR-467a, and miR-486) were analyzed in mouse MV" -circulation_biomarker_diagnosis_ns hsa-mir-215 Cerebral Malaria 29747626 "The differential expression profiles of these selected miRNA (miR-146a, miR-150, miR-193b, miR-205, miR-215, miR-467a, and miR-486) were analyzed in mouse MV" -circulation_biomarker_diagnosis_ns hsa-mir-467a Cerebral Malaria 29747626 "The differential expression profiles of these selected miRNA (miR-146a, miR-150, miR-193b, miR-205, miR-215, miR-467a, and miR-486) were analyzed in mouse MV" -circulation_biomarker_diagnosis_ns hsa-mir-486 Cerebral Malaria 29747626 "The differential expression profiles of these selected miRNA (miR-146a, miR-150, miR-193b, miR-205, miR-215, miR-467a, and miR-486) were analyzed in mouse MV" -circulation_biomarker_diagnosis_ns hsa-mir-106a Proliferative Glomerulonephritis 29748623 Plasma microRNA panel is a novel biomarker for focal segmental glomerulosclerosis and associated with podocyte apoptosis. -circulation_biomarker_diagnosis_ns hsa-mir-1229 Colorectal Carcinoma 29780253 "A 5-serum miRNA panel (miRNA-1246, miRNA-202-3p, miRNA-21-3p, miRNA-1229-3p, and miRNA-532-3p) effectively distinguished CRCs from HCs" -circulation_biomarker_diagnosis_ns hsa-mir-1246 Colorectal Carcinoma 29780253 "A 5-serum miRNA panel (miRNA-1246, miRNA-202-3p, miRNA-21-3p, miRNA-1229-3p, and miRNA-532-3p) effectively distinguished CRCs from HCs" -circulation_biomarker_diagnosis_ns hsa-mir-202 Colorectal Carcinoma 29780253 "A 5-serum miRNA panel (miRNA-1246, miRNA-202-3p, miRNA-21-3p, miRNA-1229-3p, and miRNA-532-3p) effectively distinguished CRCs from HCs" -circulation_biomarker_diagnosis_ns hsa-mir-21 Colorectal Carcinoma 29780253 "A 5-serum miRNA panel (miRNA-1246, miRNA-202-3p, miRNA-21-3p, miRNA-1229-3p, and miRNA-532-3p) effectively distinguished CRCs from HCs" -circulation_biomarker_diagnosis_ns hsa-mir-532 Colorectal Carcinoma 29780253 "A 5-serum miRNA panel (miRNA-1246, miRNA-202-3p, miRNA-21-3p, miRNA-1229-3p, and miRNA-532-3p) effectively distinguished CRCs from HCs" -circulation_biomarker_diagnosis_ns hsa-mir-451 Pulmonary Hypertension 29795360 Plasma miR-451 with echocardiography serves as a diagnostic reference for pulmonary hypertension. -circulation_biomarker_diagnosis_ns hsa-let-7a Diabetic Retinopathy 29812988 "a panel of three miRNAs (hsa-let-7a-5p, hsa-miR-novel-chr5_15976, and hsa-miR-28-3p) presented 0.92 sensitivity and 0.94 specificity for distinguishing T2DM-DR from T2DM-no-DR" -circulation_biomarker_diagnosis_ns hsa-mir-28 Diabetic Retinopathy 29812988 "a panel of three miRNAs (hsa-let-7a-5p, hsa-miR-novel-chr5_15976, and hsa-miR-28-3p) presented 0.92 sensitivity and 0.94 specificity for distinguishing T2DM-DR from T2DM-no-DR" -circulation_biomarker_diagnosis_ns hsa-mir-93 Uterine Cancer 29844841 Expression of serum Hsa-miR-93 in uterine cancer and its clinical significance. -circulation_biomarker_diagnosis_ns hsa-mir-192 Diabetic Nephropathy 29845236 Expression of microRNA?377 and microRNA?192 and their potential as blood?based biomarkers for early detection of type 2 diabetic nephropathy. -circulation_biomarker_diagnosis_ns hsa-mir-377 Diabetic Nephropathy 29845236 Expression of microRNA?377 and microRNA?192 and their potential as blood?based biomarkers for early detection of type 2 diabetic nephropathy. -circulation_biomarker_diagnosis_ns hsa-mir-29b Endometrial Neoplasms 29848072 Expression and prognostic value of miRNA-29b in peripheral blood for endometrial cancer. -circulation_biomarker_diagnosis_ns hsa-mir-21 Atrial Fibrillation 29848477 Circulating MicroRNA-21 Correlates With Left Atrial Low-Voltage Areas and Is Associated With Procedure Outcome in Patients Undergoing Atrial Fibrillation Ablation. -circulation_biomarker_diagnosis_ns hsa-mir-503 Coronary Artery Disease 29870767 The relationship of plasma miR-503 and coronary collateral circulation in patients with coronary artery disease. -circulation_biomarker_diagnosis_ns hsa-mir-122 Chronic Hepatitis B 29881991 Plasma miRNA-122-5p and miRNA-151a-3p identified as potential biomarkers for liver injury among CHB patients with PNALT. -circulation_biomarker_diagnosis_ns hsa-mir-151a Chronic Hepatitis B 29881991 Plasma miRNA-122-5p and miRNA-151a-3p identified as potential biomarkers for liver injury among CHB patients with PNALT. -circulation_biomarker_diagnosis_ns hsa-mir-107 Alzheimer Disease 29885309 "Only six of these were consistent in their direction of expression between studies (miR-107, miR-125b, miR-146a, miR-181c, miR-29b, and miR-342), and they were all shown to be down regulated in individuals with AD compared to controls" -circulation_biomarker_diagnosis_ns hsa-mir-125b Alzheimer Disease 29885309 "Only six of these were consistent in their direction of expression between studies (miR-107, miR-125b, miR-146a, miR-181c, miR-29b, and miR-342), and they were all shown to be down regulated in individuals with AD compared to controls" -circulation_biomarker_diagnosis_ns hsa-mir-146a Alzheimer Disease 29885309 "Only six of these were consistent in their direction of expression between studies (miR-107, miR-125b, miR-146a, miR-181c, miR-29b, and miR-342), and they were all shown to be down regulated in individuals with AD compared to controls" -circulation_biomarker_diagnosis_ns hsa-mir-181c Alzheimer Disease 29885309 "Only six of these were consistent in their direction of expression between studies (miR-107, miR-125b, miR-146a, miR-181c, miR-29b, and miR-342), and they were all shown to be down regulated in individuals with AD compared to controls" -circulation_biomarker_diagnosis_ns hsa-mir-29b Alzheimer Disease 29885309 "Only six of these were consistent in their direction of expression between studies (miR-107, miR-125b, miR-146a, miR-181c, miR-29b, and miR-342), and they were all shown to be down regulated in individuals with AD compared to controls" -circulation_biomarker_diagnosis_ns hsa-mir-342 Alzheimer Disease 29885309 "Only six of these were consistent in their direction of expression between studies (miR-107, miR-125b, miR-146a, miR-181c, miR-29b, and miR-342), and they were all shown to be down regulated in individuals with AD compared to controls" -circulation_biomarker_diagnosis_ns hsa-mir-509 Congenital Heart Diseases 29890280 Clinical diagnostic value of circulating serum miR-509-3p in pulmonary arterial hypertension with congenital heart disease. -circulation_biomarker_diagnosis_ns hsa-mir-16 Rheumatoid Arthritis 29892977 Circulating serum miR-223-3p and miR-16-5p as possible biomarkers of early rheumatoid arthritis. -circulation_biomarker_diagnosis_ns hsa-mir-223 Rheumatoid Arthritis 29892977 Circulating serum miR-223-3p and miR-16-5p as possible biomarkers of early rheumatoid arthritis. -circulation_biomarker_diagnosis_ns hsa-mir-17 Endometriosis 29901577 "the present study characterizes the role of miR-17, IL-4, and IL-6 in the pathogenesis of endometriosis, suggesting the feasibility of using miR-17 and selected cytokines as a noninvasive diagnostic test for the detection of endometriosis" -circulation_biomarker_diagnosis_ns hsa-mir-126 Diabetic Nephropathy 29902497 "6 miRNAs were consistently dysregulated in DKD patients compared to controls: miR-21-5p, miR-29a-3p, miR-126-3p, miR-192-5p, miR-214-3p, and miR-342-3p" -circulation_biomarker_diagnosis_ns hsa-mir-192 Diabetic Nephropathy 29902497 "6 miRNAs were consistently dysregulated in DKD patients compared to controls: miR-21-5p, miR-29a-3p, miR-126-3p, miR-192-5p, miR-214-3p, and miR-342-3p" -circulation_biomarker_diagnosis_ns hsa-mir-21 Diabetic Nephropathy 29902497 "6 miRNAs were consistently dysregulated in DKD patients compared to controls: miR-21-5p, miR-29a-3p, miR-126-3p, miR-192-5p, miR-214-3p, and miR-342-3p" -circulation_biomarker_diagnosis_ns hsa-mir-214 Diabetic Nephropathy 29902497 "6 miRNAs were consistently dysregulated in DKD patients compared to controls: miR-21-5p, miR-29a-3p, miR-126-3p, miR-192-5p, miR-214-3p, and miR-342-3p" -circulation_biomarker_diagnosis_ns hsa-mir-29a Diabetic Nephropathy 29902497 "6 miRNAs were consistently dysregulated in DKD patients compared to controls: miR-21-5p, miR-29a-3p, miR-126-3p, miR-192-5p, miR-214-3p, and miR-342-3p" -circulation_biomarker_diagnosis_ns hsa-mir-342 Diabetic Nephropathy 29902497 "6 miRNAs were consistently dysregulated in DKD patients compared to controls: miR-21-5p, miR-29a-3p, miR-126-3p, miR-192-5p, miR-214-3p, and miR-342-3p" -circulation_biomarker_diagnosis_ns hsa-mir-215 Osteosarcoma 29907935 Circulating miR-215-5p and miR-642a-5p as potential biomarker for diagnosis of osteosarcoma in Mexican population. -circulation_biomarker_diagnosis_ns hsa-mir-642a Osteosarcoma 29907935 Circulating miR-215-5p and miR-642a-5p as potential biomarker for diagnosis of osteosarcoma in Mexican population. -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Pancreatic" 29922178 the diagnostic value of miR-21 in PA was also demonstrated by the pooled sensitivity -circulation_biomarker_diagnosis_ns hsa-mir-122 Primary Sclerosing Cholangitis 29922759 Serum miRNA-122 is an independent biomarker of survival in patients with primary sclerosing cholangitis. -circulation_biomarker_diagnosis_ns hsa-let-7a Gastric Neoplasms 29923196 "deregulation of several circulating miRNAs (i.e., let-7a, miR-21, miR-93, miR-192a, miR-18a, and miR-10b for gastric cancer, and miR-21, miR-375, miR-25-3p, miR-151a-3p, and miR-100-3p for esophageal cancer)" -circulation_biomarker_diagnosis_ns hsa-mir-100 Esophageal Neoplasms 29923196 "deregulation of several circulating miRNAs (i.e., let-7a, miR-21, miR-93, miR-192a, miR-18a, and miR-10b for gastric cancer, and miR-21, miR-375, miR-25-3p, miR-151a-3p, and miR-100-3p for esophageal cancer)" -circulation_biomarker_diagnosis_ns hsa-mir-10b Gastric Neoplasms 29923196 "deregulation of several circulating miRNAs (i.e., let-7a, miR-21, miR-93, miR-192a, miR-18a, and miR-10b for gastric cancer, and miR-21, miR-375, miR-25-3p, miR-151a-3p, and miR-100-3p for esophageal cancer)" -circulation_biomarker_diagnosis_ns hsa-mir-151a Esophageal Neoplasms 29923196 "deregulation of several circulating miRNAs (i.e., let-7a, miR-21, miR-93, miR-192a, miR-18a, and miR-10b for gastric cancer, and miR-21, miR-375, miR-25-3p, miR-151a-3p, and miR-100-3p for esophageal cancer)" -circulation_biomarker_diagnosis_ns hsa-mir-18a Gastric Neoplasms 29923196 "deregulation of several circulating miRNAs (i.e., let-7a, miR-21, miR-93, miR-192a, miR-18a, and miR-10b for gastric cancer, and miR-21, miR-375, miR-25-3p, miR-151a-3p, and miR-100-3p for esophageal cancer)" -circulation_biomarker_diagnosis_ns hsa-mir-192a Gastric Neoplasms 29923196 "deregulation of several circulating miRNAs (i.e., let-7a, miR-21, miR-93, miR-192a, miR-18a, and miR-10b for gastric cancer, and miR-21, miR-375, miR-25-3p, miR-151a-3p, and miR-100-3p for esophageal cancer)" -circulation_biomarker_diagnosis_ns hsa-mir-21 Esophageal Neoplasms 29923196 "deregulation of several circulating miRNAs (i.e., let-7a, miR-21, miR-93, miR-192a, miR-18a, and miR-10b for gastric cancer, and miR-21, miR-375, miR-25-3p, miR-151a-3p, and miR-100-3p for esophageal cancer)" -circulation_biomarker_diagnosis_ns hsa-mir-21 Gastric Neoplasms 29923196 "deregulation of several circulating miRNAs (i.e., let-7a, miR-21, miR-93, miR-192a, miR-18a, and miR-10b for gastric cancer, and miR-21, miR-375, miR-25-3p, miR-151a-3p, and miR-100-3p for esophageal cancer)" -circulation_biomarker_diagnosis_ns hsa-mir-25 Esophageal Neoplasms 29923196 "deregulation of several circulating miRNAs (i.e., let-7a, miR-21, miR-93, miR-192a, miR-18a, and miR-10b for gastric cancer, and miR-21, miR-375, miR-25-3p, miR-151a-3p, and miR-100-3p for esophageal cancer)" -circulation_biomarker_diagnosis_ns hsa-mir-375 Esophageal Neoplasms 29923196 "deregulation of several circulating miRNAs (i.e., let-7a, miR-21, miR-93, miR-192a, miR-18a, and miR-10b for gastric cancer, and miR-21, miR-375, miR-25-3p, miR-151a-3p, and miR-100-3p for esophageal cancer)" -circulation_biomarker_diagnosis_ns hsa-mir-93 Gastric Neoplasms 29923196 "deregulation of several circulating miRNAs (i.e., let-7a, miR-21, miR-93, miR-192a, miR-18a, and miR-10b for gastric cancer, and miR-21, miR-375, miR-25-3p, miR-151a-3p, and miR-100-3p for esophageal cancer)" -circulation_biomarker_diagnosis_ns hsa-mir-106a Gastric Neoplasms 29929476 "circulating miR-21, miR-93, miR-106a and miR-106b could be used as diagnostic plasma biomarkers in gastric cancer patients" -circulation_biomarker_diagnosis_ns hsa-mir-106b Gastric Neoplasms 29929476 "circulating miR-21, miR-93, miR-106a and miR-106b could be used as diagnostic plasma biomarkers in gastric cancer patients" -circulation_biomarker_diagnosis_ns hsa-mir-21 Gastric Neoplasms 29929476 "circulating miR-21, miR-93, miR-106a and miR-106b could be used as diagnostic plasma biomarkers in gastric cancer patients" -circulation_biomarker_diagnosis_ns hsa-mir-93 Gastric Neoplasms 29929476 "circulating miR-21, miR-93, miR-106a and miR-106b could be used as diagnostic plasma biomarkers in gastric cancer patients" -circulation_biomarker_diagnosis_ns hsa-mir-21 Gastric Neoplasms 29936770 Clinical application value of combined detection of serum miR-378 and miR-21 in gastric cancer -circulation_biomarker_diagnosis_ns hsa-mir-378 Gastric Neoplasms 29936770 Clinical application value of combined detection of serum miR-378 and miR-21 in gastric cancer -circulation_biomarker_diagnosis_ns hsa-mir-146b Asthma 29940952 "Stepwise logistic regression yielded a 3-microRNA model (miR-146b, miR-206 and miR-720) that, combined with the exacerbation clinical score, had excellent predictive power with a 0.81 AUROC" -circulation_biomarker_diagnosis_ns hsa-mir-206 Asthma 29940952 "Stepwise logistic regression yielded a 3-microRNA model (miR-146b, miR-206 and miR-720) that, combined with the exacerbation clinical score, had excellent predictive power with a 0.81 AUROC" -circulation_biomarker_diagnosis_ns hsa-mir-720 Asthma 29940952 "Stepwise logistic regression yielded a 3-microRNA model (miR-146b, miR-206 and miR-720) that, combined with the exacerbation clinical score, had excellent predictive power with a 0.81 AUROC" -circulation_biomarker_diagnosis_ns hsa-mir-338 Colorectal Carcinoma 29952077 Circulating miR-338-5p is a potential diagnostic biomarker in colorectal cancer. -circulation_biomarker_diagnosis_ns hsa-mir-146a Pulmonary Sarcoidosis 29956871 "Our data provide evidence that exosomes and microvesicles as extracellular vesicles are present in the bronchoalveolar space of sarcoidosis patients and they differentially express EV miRNA (miR-146a and miR-150), the expression of which correlates negatively with pulmonary function indices" -circulation_biomarker_diagnosis_ns hsa-mir-150 Pulmonary Sarcoidosis 29956871 "Our data provide evidence that exosomes and microvesicles as extracellular vesicles are present in the bronchoalveolar space of sarcoidosis patients and they differentially express EV miRNA (miR-146a and miR-150), the expression of which correlates negatively with pulmonary function indices" -circulation_biomarker_diagnosis_ns hsa-mir-10a "Carcinoma, Hepatocellular" 29962816 "The four serum miRNAs (miR-375, miR-10a, miR-122 and miR-423) could potentially serve as novel biomarkers for the diagnostic and prognostic of HCC" -circulation_biomarker_diagnosis_ns hsa-mir-122 "Carcinoma, Hepatocellular" 29962816 "The four serum miRNAs (miR-375, miR-10a, miR-122 and miR-423) could potentially serve as novel biomarkers for the diagnostic and prognostic of HCC" -circulation_biomarker_diagnosis_ns hsa-mir-375 "Carcinoma, Hepatocellular" 29962816 "The four serum miRNAs (miR-375, miR-10a, miR-122 and miR-423) could potentially serve as novel biomarkers for the diagnostic and prognostic of HCC" -circulation_biomarker_diagnosis_ns hsa-mir-423 "Carcinoma, Hepatocellular" 29962816 "The four serum miRNAs (miR-375, miR-10a, miR-122 and miR-423) could potentially serve as novel biomarkers for the diagnostic and prognostic of HCC" -circulation_biomarker_diagnosis_ns hsa-let-7i Traumatic Brain Injury 29963002 "Promising miRNAs such as miR-21, miR-16 or let-7i were identified as suitable candidate biomarkers for TBI" -circulation_biomarker_diagnosis_ns hsa-mir-16 Traumatic Brain Injury 29963002 "Promising miRNAs such as miR-21, miR-16 or let-7i were identified as suitable candidate biomarkers for TBI" -circulation_biomarker_diagnosis_ns hsa-mir-21 Traumatic Brain Injury 29963002 "Promising miRNAs such as miR-21, miR-16 or let-7i were identified as suitable candidate biomarkers for TBI" -circulation_biomarker_diagnosis_ns hsa-mir-125a Lupus Nephritis 29963250 "mir-125a-5p, miR-146a-5p, and mir-221-3p were found to be statistically significant not only in the screening study but also in the real-time qPCR verification studies" -circulation_biomarker_diagnosis_ns hsa-mir-146a Lupus Nephritis 29963250 "mir-125a-5p, miR-146a-5p, and mir-221-3p were found to be statistically significant not only in the screening study but also in the real-time qPCR verification studies" -circulation_biomarker_diagnosis_ns hsa-mir-221 Lupus Nephritis 29963250 "mir-125a-5p, miR-146a-5p, and mir-221-3p were found to be statistically significant not only in the screening study but also in the real-time qPCR verification studies" -circulation_biomarker_diagnosis_ns hsa-mir-652 "Leukemia, Lymphoblastic, Acute" 29967774 Expression of miR-652-3p and Effect on Apoptosis and Drug Sensitivity in Pediatric Acute Lymphoblastic Leukemia. -circulation_biomarker_diagnosis_ns hsa-mir-146a Rheumatoid Arthritis 29968332 MiR-146a levels in rheumatoid arthritis and their correlation with disease activity: a meta-analysis. -circulation_biomarker_diagnosis_ns hsa-mir-100 Recurrent Spontaneous Abortion 29973278 "Circulating miR-23a-3p, miR-27a-3p, miR-29a-3p, miR-100-5p, miR-127-3p and miR-486-5 might be involved in RM pathogenesis and present potential diagnostic biomarkers for RM" -circulation_biomarker_diagnosis_ns hsa-mir-127 Recurrent Spontaneous Abortion 29973278 "Circulating miR-23a-3p, miR-27a-3p, miR-29a-3p, miR-100-5p, miR-127-3p and miR-486-5 might be involved in RM pathogenesis and present potential diagnostic biomarkers for RM" -circulation_biomarker_diagnosis_ns hsa-mir-23a Recurrent Spontaneous Abortion 29973278 "Circulating miR-23a-3p, miR-27a-3p, miR-29a-3p, miR-100-5p, miR-127-3p and miR-486-5 might be involved in RM pathogenesis and present potential diagnostic biomarkers for RM" -circulation_biomarker_diagnosis_ns hsa-mir-27a Recurrent Spontaneous Abortion 29973278 "Circulating miR-23a-3p, miR-27a-3p, miR-29a-3p, miR-100-5p, miR-127-3p and miR-486-5 might be involved in RM pathogenesis and present potential diagnostic biomarkers for RM" -circulation_biomarker_diagnosis_ns hsa-mir-29a Recurrent Spontaneous Abortion 29973278 "Circulating miR-23a-3p, miR-27a-3p, miR-29a-3p, miR-100-5p, miR-127-3p and miR-486-5 might be involved in RM pathogenesis and present potential diagnostic biomarkers for RM" -circulation_biomarker_diagnosis_ns hsa-mir-486 Recurrent Spontaneous Abortion 29973278 "Circulating miR-23a-3p, miR-27a-3p, miR-29a-3p, miR-100-5p, miR-127-3p and miR-486-5 might be involved in RM pathogenesis and present potential diagnostic biomarkers for RM" -circulation_biomarker_diagnosis_ns hsa-let-7b Graves Disease 29976201 Serum and thyroid tissue level of let-7b and their correlation with TRAb in Graves' disease. -circulation_biomarker_diagnosis_ns hsa-mir-21 "Adenocarcinoma, Pancreatic Ductal" 29976637 Pre-operative Plasma miR-21-5p Is a Sensitive Biomarker and Independent Prognostic Factor in Patients with Pancreatic Ductal Adenocarcinoma Undergoing Surgical Resection. -circulation_biomarker_diagnosis_ns hsa-mir-411 "Carcinoma, Lung, Non-Small-Cell" 29976955 "miR-411-5p edited in position 5 was significantly dysregulated in tissues as well as in exosomes of NSCLC patients, suggesting a potential targetome shift relevant to lung cancer biology" -circulation_biomarker_diagnosis_ns hsa-mir-19b "Lymphoma, Large B-Cell, Diffuse" 29977116 "miR-19b, miR-20a, and miR-451 could enable to differentiate, at the remission review, patients with residual tumor, from patients with complete remission." -circulation_biomarker_diagnosis_ns hsa-mir-20a "Lymphoma, Large B-Cell, Diffuse" 29977116 "miR-19b, miR-20a, and miR-451 could enable to differentiate, at the remission review, patients with residual tumor, from patients with complete remission." -circulation_biomarker_diagnosis_ns hsa-mir-451 "Lymphoma, Large B-Cell, Diffuse" 29977116 "miR-19b, miR-20a, and miR-451 could enable to differentiate, at the remission review, patients with residual tumor, from patients with complete remission." -circulation_biomarker_diagnosis_ns hsa-mir-155 "Carcinoma, Breast" 29981251 "the serum levels of c-miR16, c-miR21, c-miR155, and c-miR195 could be used as biomarkers to improve the early diagnosis of breast cancer" -circulation_biomarker_diagnosis_ns hsa-mir-16 "Carcinoma, Breast" 29981251 "the serum levels of c-miR16, c-miR21, c-miR155, and c-miR195 could be used as biomarkers to improve the early diagnosis of breast cancer" -circulation_biomarker_diagnosis_ns hsa-mir-195 "Carcinoma, Breast" 29981251 "the serum levels of c-miR16, c-miR21, c-miR155, and c-miR195 could be used as biomarkers to improve the early diagnosis of breast cancer" -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Breast" 29981251 "the serum levels of c-miR16, c-miR21, c-miR155, and c-miR195 could be used as biomarkers to improve the early diagnosis of breast cancer" -circulation_biomarker_diagnosis_ns hsa-mir-190 "Carcinoma, Breast" 29996899 "A combination of of miR-21, miR-23b and miR-190 showe higher sensitivity and specificity in ROC analyses compared to each miRNA alone" -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Breast" 29996899 "A combination of of miR-21, miR-23b and miR-190 showe higher sensitivity and specificity in ROC analyses compared to each miRNA alone" -circulation_biomarker_diagnosis_ns hsa-mir-23b "Carcinoma, Breast" 29996899 "A combination of of miR-21, miR-23b and miR-190 showe higher sensitivity and specificity in ROC analyses compared to each miRNA alone" -circulation_biomarker_diagnosis_ns hsa-mir-150 "Carcinoma, Hepatocellular" 30003924 Role of circulating miR-182 and miR-150 as biomarkers for cirrhosis and hepatocellular carcinoma post HCV infection in Egyptian patients. -circulation_biomarker_diagnosis_ns hsa-mir-182 "Carcinoma, Hepatocellular" 30003924 Role of circulating miR-182 and miR-150 as biomarkers for cirrhosis and hepatocellular carcinoma post HCV infection in Egyptian patients. -circulation_biomarker_diagnosis_ns hsa-mir-122 "Fatty Liver, Non-Alcoholic" 30006517 "we have re-examined the predictive value of these serum microRNAs and found that 9 of them (miR-34a, -192, -27b, -122, -22, -21, -197, -30c and -16) associated to NAFLD severity in our independent cohort" -circulation_biomarker_diagnosis_ns hsa-mir-16 "Fatty Liver, Non-Alcoholic" 30006517 "we have re-examined the predictive value of these serum microRNAs and found that 9 of them (miR-34a, -192, -27b, -122, -22, -21, -197, -30c and -16) associated to NAFLD severity in our independent cohort" -circulation_biomarker_diagnosis_ns hsa-mir-192 "Fatty Liver, Non-Alcoholic" 30006517 "we have re-examined the predictive value of these serum microRNAs and found that 9 of them (miR-34a, -192, -27b, -122, -22, -21, -197, -30c and -16) associated to NAFLD severity in our independent cohort" -circulation_biomarker_diagnosis_ns hsa-mir-197 "Fatty Liver, Non-Alcoholic" 30006517 "we have re-examined the predictive value of these serum microRNAs and found that 9 of them (miR-34a, -192, -27b, -122, -22, -21, -197, -30c and -16) associated to NAFLD severity in our independent cohort" -circulation_biomarker_diagnosis_ns hsa-mir-21 "Fatty Liver, Non-Alcoholic" 30006517 "we have re-examined the predictive value of these serum microRNAs and found that 9 of them (miR-34a, -192, -27b, -122, -22, -21, -197, -30c and -16) associated to NAFLD severity in our independent cohort" -circulation_biomarker_diagnosis_ns hsa-mir-22 "Fatty Liver, Non-Alcoholic" 30006517 "we have re-examined the predictive value of these serum microRNAs and found that 9 of them (miR-34a, -192, -27b, -122, -22, -21, -197, -30c and -16) associated to NAFLD severity in our independent cohort" -circulation_biomarker_diagnosis_ns hsa-mir-27b "Fatty Liver, Non-Alcoholic" 30006517 "we have re-examined the predictive value of these serum microRNAs and found that 9 of them (miR-34a, -192, -27b, -122, -22, -21, -197, -30c and -16) associated to NAFLD severity in our independent cohort" -circulation_biomarker_diagnosis_ns hsa-mir-30c "Fatty Liver, Non-Alcoholic" 30006517 "we have re-examined the predictive value of these serum microRNAs and found that 9 of them (miR-34a, -192, -27b, -122, -22, -21, -197, -30c and -16) associated to NAFLD severity in our independent cohort" -circulation_biomarker_diagnosis_ns hsa-mir-34a "Fatty Liver, Non-Alcoholic" 30006517 "we have re-examined the predictive value of these serum microRNAs and found that 9 of them (miR-34a, -192, -27b, -122, -22, -21, -197, -30c and -16) associated to NAFLD severity in our independent cohort" -circulation_biomarker_diagnosis_ns hsa-let-7a "Cardiomyopathy, Dilated" 30008018 "Among the candidates, let-7a-5p, miR-142-3p, miR-145-5p and miR-454-3p levels were significantly increased in LMNAMUT carriers compared to LMNAWT controls and iDCM patients" -circulation_biomarker_diagnosis_ns hsa-mir-142 "Cardiomyopathy, Dilated" 30008018 "Among the candidates, let-7a-5p, miR-142-3p, miR-145-5p and miR-454-3p levels were significantly increased in LMNAMUT carriers compared to LMNAWT controls and iDCM patients" -circulation_biomarker_diagnosis_ns hsa-mir-145 "Cardiomyopathy, Dilated" 30008018 "Among the candidates, let-7a-5p, miR-142-3p, miR-145-5p and miR-454-3p levels were significantly increased in LMNAMUT carriers compared to LMNAWT controls and iDCM patients" -circulation_biomarker_diagnosis_ns hsa-mir-454 "Cardiomyopathy, Dilated" 30008018 "Among the candidates, let-7a-5p, miR-142-3p, miR-145-5p and miR-454-3p levels were significantly increased in LMNAMUT carriers compared to LMNAWT controls and iDCM patients" -circulation_biomarker_diagnosis_ns hsa-mir-150 Diabetic Retinopathy 30008390 "Our data suggest a role for miR-150-5p, miR-21-3p and miR-30b-5p as potential biomarkers of the onset of diabetic retinopathy" -circulation_biomarker_diagnosis_ns hsa-mir-21 Diabetic Retinopathy 30008390 "Our data suggest a role for miR-150-5p, miR-21-3p and miR-30b-5p as potential biomarkers of the onset of diabetic retinopathy" -circulation_biomarker_diagnosis_ns hsa-mir-30b Diabetic Retinopathy 30008390 "Our data suggest a role for miR-150-5p, miR-21-3p and miR-30b-5p as potential biomarkers of the onset of diabetic retinopathy" -circulation_biomarker_diagnosis_ns hsa-let-7b Pulmonary Hypertension 30013141 "dysregulations in miRNAs let-7b-5p, -7c-5p, miR-1307-3p, -185-3p, -8084, -331-3p and -210-3p may be detrimental for the development and function of the lungs and pulmonary vasculature" -circulation_biomarker_diagnosis_ns hsa-let-7c Pulmonary Hypertension 30013141 "dysregulations in miRNAs let-7b-5p, -7c-5p, miR-1307-3p, -185-3p, -8084, -331-3p and -210-3p may be detrimental for the development and function of the lungs and pulmonary vasculature" -circulation_biomarker_diagnosis_ns hsa-mir-1307 Pulmonary Hypertension 30013141 "dysregulations in miRNAs let-7b-5p, -7c-5p, miR-1307-3p, -185-3p, -8084, -331-3p and -210-3p may be detrimental for the development and function of the lungs and pulmonary vasculature" -circulation_biomarker_diagnosis_ns hsa-mir-185 Pulmonary Hypertension 30013141 "dysregulations in miRNAs let-7b-5p, -7c-5p, miR-1307-3p, -185-3p, -8084, -331-3p and -210-3p may be detrimental for the development and function of the lungs and pulmonary vasculature" -circulation_biomarker_diagnosis_ns hsa-mir-210 Pulmonary Hypertension 30013141 "dysregulations in miRNAs let-7b-5p, -7c-5p, miR-1307-3p, -185-3p, -8084, -331-3p and -210-3p may be detrimental for the development and function of the lungs and pulmonary vasculature" -circulation_biomarker_diagnosis_ns hsa-mir-331 Pulmonary Hypertension 30013141 "dysregulations in miRNAs let-7b-5p, -7c-5p, miR-1307-3p, -185-3p, -8084, -331-3p and -210-3p may be detrimental for the development and function of the lungs and pulmonary vasculature" -circulation_biomarker_diagnosis_ns hsa-mir-8084 Pulmonary Hypertension 30013141 "dysregulations in miRNAs let-7b-5p, -7c-5p, miR-1307-3p, -185-3p, -8084, -331-3p and -210-3p may be detrimental for the development and function of the lungs and pulmonary vasculature" -circulation_biomarker_diagnosis_ns hsa-mir-18a Cystic Fibrosis 30014495 Expression levels of serum miR-18a-5p were correlated with increasing hepatic fibrosis stage in CFLD -circulation_biomarker_diagnosis_ns hsa-mir-1165 Allergic Asthma 30015513 A novel microRNA miR-1165-3p as a potential diagnostic biomarker for allergic asthma. -circulation_biomarker_diagnosis_ns hsa-mir-21 Hepatic Veno-Occlusive Disease 30019166 we found that LSEC-derived miR-21-5p and especially miR-511-3p in serum would serve as early phase biomarkers for SOS in response to LSEC damage -circulation_biomarker_diagnosis_ns hsa-mir-511 Hepatic Veno-Occlusive Disease 30019166 we found that LSEC-derived miR-21-5p and especially miR-511-3p in serum would serve as early phase biomarkers for SOS in response to LSEC damage -circulation_biomarker_diagnosis_ns hsa-mir-155 Lymphoma 30021904 Enhancer control of miR-155 expression in Epstein-Barr virus infected B cells. -circulation_biomarker_diagnosis_ns hsa-mir-122 "Fatty Liver, Non-Alcoholic" 30030064 "Plasma miR-17, miR-20a, miR-20b and miR-122 as potential biomarkers for diagnosis of NAFLD in type 2 diabetes mellitus patients." -circulation_biomarker_diagnosis_ns hsa-mir-17 "Fatty Liver, Non-Alcoholic" 30030064 "Plasma miR-17, miR-20a, miR-20b and miR-122 as potential biomarkers for diagnosis of NAFLD in type 2 diabetes mellitus patients." -circulation_biomarker_diagnosis_ns hsa-mir-20a "Fatty Liver, Non-Alcoholic" 30030064 "Plasma miR-17, miR-20a, miR-20b and miR-122 as potential biomarkers for diagnosis of NAFLD in type 2 diabetes mellitus patients." -circulation_biomarker_diagnosis_ns hsa-mir-20b "Fatty Liver, Non-Alcoholic" 30030064 "Plasma miR-17, miR-20a, miR-20b and miR-122 as potential biomarkers for diagnosis of NAFLD in type 2 diabetes mellitus patients." -circulation_biomarker_diagnosis_ns hsa-mir-126 Acute Ischemic Stroke 30030634 "Circulating miR-126 and miR-130a levels correlate with lower disease risk, disease severity, and reduced inflammatory cytokine levels in acute ischemic stroke patients." -circulation_biomarker_diagnosis_ns hsa-mir-130a Acute Ischemic Stroke 30030634 "Circulating miR-126 and miR-130a levels correlate with lower disease risk, disease severity, and reduced inflammatory cytokine levels in acute ischemic stroke patients." -circulation_biomarker_diagnosis_ns hsa-let-7c Graft-Versus-Host Disease 30042760 Differential MicroRNA Expression Levels in Cutaneous Acute Graft-Versus-Host Disease. -circulation_biomarker_diagnosis_ns hsa-mir-34a Graft-Versus-Host Disease 30042760 Differential MicroRNA Expression Levels in Cutaneous Acute Graft-Versus-Host Disease. -circulation_biomarker_diagnosis_ns hsa-mir-365a Graft-Versus-Host Disease 30042760 Differential MicroRNA Expression Levels in Cutaneous Acute Graft-Versus-Host Disease. -circulation_biomarker_diagnosis_ns hsa-mir-503 Graft-Versus-Host Disease 30042760 Differential MicroRNA Expression Levels in Cutaneous Acute Graft-Versus-Host Disease. -circulation_biomarker_diagnosis_ns hsa-mir-1915 "Carcinoma, Breast" 30048472 Identification of serum miR-1915-3p and miR-455-3p as biomarkers for breast cancer. -circulation_biomarker_diagnosis_ns hsa-mir-455 "Carcinoma, Breast" 30048472 Identification of serum miR-1915-3p and miR-455-3p as biomarkers for breast cancer. -circulation_biomarker_diagnosis_ns hsa-mir-142 Cerebral Malaria 30050092 "Differentially expressed microRNAs in experimental cerebral malaria and their involvement in endocytosis, adherens junctions, FoxO and TGF-¦Â signalling pathways." -circulation_biomarker_diagnosis_ns hsa-mir-19a Cerebral Malaria 30050092 "Differentially expressed microRNAs in experimental cerebral malaria and their involvement in endocytosis, adherens junctions, FoxO and TGF-¦Â signalling pathways." -circulation_biomarker_diagnosis_ns hsa-mir-19b Cerebral Malaria 30050092 "Differentially expressed microRNAs in experimental cerebral malaria and their involvement in endocytosis, adherens junctions, FoxO and TGF-¦Â signalling pathways." -circulation_biomarker_diagnosis_ns hsa-mir-223 Cerebral Malaria 30050092 "Differentially expressed microRNAs in experimental cerebral malaria and their involvement in endocytosis, adherens junctions, FoxO and TGF-¦Â signalling pathways." -circulation_biomarker_diagnosis_ns hsa-mir-126 Heart Failure 30054123 Serum microRNA-126 and -223 as new-generation biomarkers for sarcoidosis in patients with heart failure. -circulation_biomarker_diagnosis_ns hsa-mir-223 Heart Failure 30054123 Serum microRNA-126 and -223 as new-generation biomarkers for sarcoidosis in patients with heart failure. -circulation_biomarker_diagnosis_ns hsa-mir-488 "Carcinoma, Breast" 30061217 Circulating Pre-microRNA-488 in Peripheral Blood Is a Potential Biomarker for Predicting Recurrence in Breast Cancer. -circulation_biomarker_diagnosis_ns hsa-mir-144 "Carcinoma, Hepatocellular" 30065664 Extracellular Vesicle-Associated mir-21 and mir-144 Are Markedly Elevated in Serum of Patients With Hepatocellular Carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-21 "Carcinoma, Hepatocellular" 30065664 Extracellular Vesicle-Associated mir-21 and mir-144 Are Markedly Elevated in Serum of Patients With Hepatocellular Carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-106a Inflammatory Bowel Diseases 30069249 Micro-RNAs -106a and -362-3p in Peripheral Blood of Inflammatory Bowel Disease Patients. -circulation_biomarker_diagnosis_ns hsa-mir-362 Inflammatory Bowel Diseases 30069249 Micro-RNAs -106a and -362-3p in Peripheral Blood of Inflammatory Bowel Disease Patients. -circulation_biomarker_diagnosis_ns hsa-mir-183 Asthma 30074411 "Circulating miRs-183-5p, -206-3p and -381-3p may serve as novel biomarkers for 4,4'-methylene diphenyl diisocyanate exposure." -circulation_biomarker_diagnosis_ns hsa-mir-206 Asthma 30074411 "Circulating miRs-183-5p, -206-3p and -381-3p may serve as novel biomarkers for 4,4'-methylene diphenyl diisocyanate exposure." -circulation_biomarker_diagnosis_ns hsa-mir-381 Asthma 30074411 "Circulating miRs-183-5p, -206-3p and -381-3p may serve as novel biomarkers for 4,4'-methylene diphenyl diisocyanate exposure." -circulation_biomarker_diagnosis_ns hsa-mir-155 "Lymphoma, Large B-Cell, Diffuse" 30076183 "MicroRNA profiling of diffuse large B-cell lymphoma cells treated with OTX015 revealed changes in the expression levels of a limited number of microRNAs, including miR-92a-1-5p, miR-21-3p, miR-155-5p and miR-96-5p" -circulation_biomarker_diagnosis_ns hsa-mir-21 "Lymphoma, Large B-Cell, Diffuse" 30076183 "MicroRNA profiling of diffuse large B-cell lymphoma cells treated with OTX015 revealed changes in the expression levels of a limited number of microRNAs, including miR-92a-1-5p, miR-21-3p, miR-155-5p and miR-96-5p" -circulation_biomarker_diagnosis_ns hsa-mir-92a "Lymphoma, Large B-Cell, Diffuse" 30076183 "MicroRNA profiling of diffuse large B-cell lymphoma cells treated with OTX015 revealed changes in the expression levels of a limited number of microRNAs, including miR-92a-1-5p, miR-21-3p, miR-155-5p and miR-96-5p" -circulation_biomarker_diagnosis_ns hsa-mir-96 "Lymphoma, Large B-Cell, Diffuse" 30076183 "MicroRNA profiling of diffuse large B-cell lymphoma cells treated with OTX015 revealed changes in the expression levels of a limited number of microRNAs, including miR-92a-1-5p, miR-21-3p, miR-155-5p and miR-96-5p" -circulation_biomarker_diagnosis_ns hsa-mir-193b "Diabetes Mellitus, Type 2" 30083267 "Levels of miR-193b-3p, miR-199a-3p, miR-20a-3p, miR-26b-5p, miR-30b-5p, miR-30c-5p, miR-374a-5p, miR-409-3p, and miR-95-3p were significantly different between Ects obtained from patients with T2DM and those obtained from healthy controls" -circulation_biomarker_diagnosis_ns hsa-mir-199a "Diabetes Mellitus, Type 2" 30083267 "Levels of miR-193b-3p, miR-199a-3p, miR-20a-3p, miR-26b-5p, miR-30b-5p, miR-30c-5p, miR-374a-5p, miR-409-3p, and miR-95-3p were significantly different between Ects obtained from patients with T2DM and those obtained from healthy controls" -circulation_biomarker_diagnosis_ns hsa-mir-20a "Diabetes Mellitus, Type 2" 30083267 "Levels of miR-193b-3p, miR-199a-3p, miR-20a-3p, miR-26b-5p, miR-30b-5p, miR-30c-5p, miR-374a-5p, miR-409-3p, and miR-95-3p were significantly different between Ects obtained from patients with T2DM and those obtained from healthy controls" -circulation_biomarker_diagnosis_ns hsa-mir-26b "Diabetes Mellitus, Type 2" 30083267 "Levels of miR-193b-3p, miR-199a-3p, miR-20a-3p, miR-26b-5p, miR-30b-5p, miR-30c-5p, miR-374a-5p, miR-409-3p, and miR-95-3p were significantly different between Ects obtained from patients with T2DM and those obtained from healthy controls" -circulation_biomarker_diagnosis_ns hsa-mir-30b "Diabetes Mellitus, Type 2" 30083267 "Levels of miR-193b-3p, miR-199a-3p, miR-20a-3p, miR-26b-5p, miR-30b-5p, miR-30c-5p, miR-374a-5p, miR-409-3p, and miR-95-3p were significantly different between Ects obtained from patients with T2DM and those obtained from healthy controls" -circulation_biomarker_diagnosis_ns hsa-mir-30c "Diabetes Mellitus, Type 2" 30083267 "Levels of miR-193b-3p, miR-199a-3p, miR-20a-3p, miR-26b-5p, miR-30b-5p, miR-30c-5p, miR-374a-5p, miR-409-3p, and miR-95-3p were significantly different between Ects obtained from patients with T2DM and those obtained from healthy controls" -circulation_biomarker_diagnosis_ns hsa-mir-374a "Diabetes Mellitus, Type 2" 30083267 "Levels of miR-193b-3p, miR-199a-3p, miR-20a-3p, miR-26b-5p, miR-30b-5p, miR-30c-5p, miR-374a-5p, miR-409-3p, and miR-95-3p were significantly different between Ects obtained from patients with T2DM and those obtained from healthy controls" -circulation_biomarker_diagnosis_ns hsa-mir-409 "Diabetes Mellitus, Type 2" 30083267 "Levels of miR-193b-3p, miR-199a-3p, miR-20a-3p, miR-26b-5p, miR-30b-5p, miR-30c-5p, miR-374a-5p, miR-409-3p, and miR-95-3p were significantly different between Ects obtained from patients with T2DM and those obtained from healthy controls" -circulation_biomarker_diagnosis_ns hsa-mir-95 "Diabetes Mellitus, Type 2" 30083267 "Levels of miR-193b-3p, miR-199a-3p, miR-20a-3p, miR-26b-5p, miR-30b-5p, miR-30c-5p, miR-374a-5p, miR-409-3p, and miR-95-3p were significantly different between Ects obtained from patients with T2DM and those obtained from healthy controls" -circulation_biomarker_diagnosis_ns hsa-mir-134 Gastric Neoplasms 30083331 "We further validated the deregulation of miR-196a-5p in precursor lesions of gastric cancer and the deregulation of miR-134-5p, miR-144-3p and miR-451a in gastric cancer" -circulation_biomarker_diagnosis_ns hsa-mir-144 Gastric Neoplasms 30083331 "We further validated the deregulation of miR-196a-5p in precursor lesions of gastric cancer and the deregulation of miR-134-5p, miR-144-3p and miR-451a in gastric cancer" -circulation_biomarker_diagnosis_ns hsa-mir-196a Gastric Neoplasms 30083331 "We further validated the deregulation of miR-196a-5p in precursor lesions of gastric cancer and the deregulation of miR-134-5p, miR-144-3p and miR-451a in gastric cancer" -circulation_biomarker_diagnosis_ns hsa-mir-451a Gastric Neoplasms 30083331 "We further validated the deregulation of miR-196a-5p in precursor lesions of gastric cancer and the deregulation of miR-134-5p, miR-144-3p and miR-451a in gastric cancer" -circulation_biomarker_diagnosis_ns hsa-mir-19b Coronary Artery Disease 30088484 "Combination of peripheral blood mononuclear cell miR-19b-5p, miR- 221, miR-25-5p, and hypertension correlates with an increased heart failure risk in coronary heart disease patients." -circulation_biomarker_diagnosis_ns hsa-mir-221 Coronary Artery Disease 30088484 "Combination of peripheral blood mononuclear cell miR-19b-5p, miR- 221, miR-25-5p, and hypertension correlates with an increased heart failure risk in coronary heart disease patients." -circulation_biomarker_diagnosis_ns hsa-mir-25 Coronary Artery Disease 30088484 "Combination of peripheral blood mononuclear cell miR-19b-5p, miR- 221, miR-25-5p, and hypertension correlates with an increased heart failure risk in coronary heart disease patients." -circulation_biomarker_diagnosis_ns hsa-mir-22 Pulmonary Hypertension 30090067 Circulating MicroRNA Markers for Pulmonary Hypertension in Supervised Exercise Intervention and Nightly Oxygen Intervention. -circulation_biomarker_diagnosis_ns hsa-mir-451a Pulmonary Hypertension 30090067 Circulating MicroRNA Markers for Pulmonary Hypertension in Supervised Exercise Intervention and Nightly Oxygen Intervention. -circulation_biomarker_diagnosis_ns hsa-mir-126 "Diabetes Mellitus, Type 2" 30093963 "For instance, three miRNAs (miR-126-3p, miR-28-3p miR-486-5p) were dysregulated in prediabetes compared to screen-detected diabetes" -circulation_biomarker_diagnosis_ns hsa-mir-28 "Diabetes Mellitus, Type 2" 30093963 "For instance, three miRNAs (miR-126-3p, miR-28-3p miR-486-5p) were dysregulated in prediabetes compared to screen-detected diabetes" -circulation_biomarker_diagnosis_ns hsa-mir-486 "Diabetes Mellitus, Type 2" 30093963 "For instance, three miRNAs (miR-126-3p, miR-28-3p miR-486-5p) were dysregulated in prediabetes compared to screen-detected diabetes" -circulation_biomarker_diagnosis_ns hsa-mir-30a "Squamous Cell Carcinoma, Oral" 30098778 The proposed combination of miR-30a-5p and miR-769-5p in plasma from OSCC patients could serve as a minimal invasive biomarker for diagnosis and control of T-site recurrences -circulation_biomarker_diagnosis_ns hsa-mir-769 "Squamous Cell Carcinoma, Oral" 30098778 The proposed combination of miR-30a-5p and miR-769-5p in plasma from OSCC patients could serve as a minimal invasive biomarker for diagnosis and control of T-site recurrences -circulation_biomarker_diagnosis_ns hsa-mir-21 Systemic Lupus Erythematosus 30105262 "miR-22-3p¦¤CT and miR-21-5p¦¤CT, were negatively correlated with caspase-10 levels, which may repress extrinsic apoptosis and increase cell survival" -circulation_biomarker_diagnosis_ns hsa-mir-22 Systemic Lupus Erythematosus 30105262 "miR-22-3p¦¤CT and miR-21-5p¦¤CT, were negatively correlated with caspase-10 levels, which may repress extrinsic apoptosis and increase cell survival" -circulation_biomarker_diagnosis_ns hsa-mir-146a Hypertension 30107841 Urinary exosome miR-146a is a potential marker of albuminuria in essential hypertension. -circulation_biomarker_diagnosis_ns hsa-mir-221 Cardiovascular Diseases [unspecific] 30115076 The inverted pattern of circulating miR-221-3p and miR-222-3p associated with isolated low HDL-C phenotype. -circulation_biomarker_diagnosis_ns hsa-mir-222 Cardiovascular Diseases [unspecific] 30115076 The inverted pattern of circulating miR-221-3p and miR-222-3p associated with isolated low HDL-C phenotype. -circulation_biomarker_diagnosis_ns hsa-mir-21 Frailty 30116492 Positive correlations between miR-21 and AOPP and between miR-483 and IL-8 were detected -circulation_biomarker_diagnosis_ns hsa-mir-483 Frailty 30116492 Positive correlations between miR-21 and AOPP and between miR-483 and IL-8 were detected -circulation_biomarker_diagnosis_ns hsa-mir-103a Spinal Cord Injuries 30122113 "miR-125b-5p, miR-146a-5p, miR-328-3p, miR-191-5p, miR-103a-3p, and miR-30b-5p correlated with both oxLDL and cIMT, and showed distinct expression between the SCI-A and SCI-S groups" -circulation_biomarker_diagnosis_ns hsa-mir-125b Spinal Cord Injuries 30122113 "miR-125b-5p, miR-146a-5p, miR-328-3p, miR-191-5p, miR-103a-3p, and miR-30b-5p correlated with both oxLDL and cIMT, and showed distinct expression between the SCI-A and SCI-S groups" -circulation_biomarker_diagnosis_ns hsa-mir-146a Spinal Cord Injuries 30122113 "miR-125b-5p, miR-146a-5p, miR-328-3p, miR-191-5p, miR-103a-3p, and miR-30b-5p correlated with both oxLDL and cIMT, and showed distinct expression between the SCI-A and SCI-S groups" -circulation_biomarker_diagnosis_ns hsa-mir-191 Spinal Cord Injuries 30122113 "miR-125b-5p, miR-146a-5p, miR-328-3p, miR-191-5p, miR-103a-3p, and miR-30b-5p correlated with both oxLDL and cIMT, and showed distinct expression between the SCI-A and SCI-S groups" -circulation_biomarker_diagnosis_ns hsa-mir-30b Spinal Cord Injuries 30122113 "miR-125b-5p, miR-146a-5p, miR-328-3p, miR-191-5p, miR-103a-3p, and miR-30b-5p correlated with both oxLDL and cIMT, and showed distinct expression between the SCI-A and SCI-S groups" -circulation_biomarker_diagnosis_ns hsa-mir-328 Spinal Cord Injuries 30122113 "miR-125b-5p, miR-146a-5p, miR-328-3p, miR-191-5p, miR-103a-3p, and miR-30b-5p correlated with both oxLDL and cIMT, and showed distinct expression between the SCI-A and SCI-S groups" -circulation_biomarker_diagnosis_ns hsa-let-7b Liver Injury 30125006 "Identification of Specific MicroRNA Biomarkers in Early Stages of Hepatocellular Injury, Cholestasis, and Steatosis in Rats." -circulation_biomarker_diagnosis_ns hsa-mir-1 Liver Injury 30125006 "Identification of Specific MicroRNA Biomarkers in Early Stages of Hepatocellular Injury, Cholestasis, and Steatosis in Rats." -circulation_biomarker_diagnosis_ns hsa-mir-143 Liver Injury 30125006 "Identification of Specific MicroRNA Biomarkers in Early Stages of Hepatocellular Injury, Cholestasis, and Steatosis in Rats." -circulation_biomarker_diagnosis_ns hsa-mir-218a Liver Injury 30125006 "Identification of Specific MicroRNA Biomarkers in Early Stages of Hepatocellular Injury, Cholestasis, and Steatosis in Rats." -circulation_biomarker_diagnosis_ns hsa-mir-320 Liver Injury 30125006 "Identification of Specific MicroRNA Biomarkers in Early Stages of Hepatocellular Injury, Cholestasis, and Steatosis in Rats." -circulation_biomarker_diagnosis_ns hsa-mir-208a Coronary Artery Disease 30126654 "Droplet digital PCR of serum miR-499, miR-21 and miR-208a for the detection of functionally relevant coronary artery disease." -circulation_biomarker_diagnosis_ns hsa-mir-21 Coronary Artery Disease 30126654 "Droplet digital PCR of serum miR-499, miR-21 and miR-208a for the detection of functionally relevant coronary artery disease." -circulation_biomarker_diagnosis_ns hsa-mir-499 Coronary Artery Disease 30126654 "Droplet digital PCR of serum miR-499, miR-21 and miR-208a for the detection of functionally relevant coronary artery disease." -circulation_biomarker_diagnosis_ns hsa-mir-30d Multiple Myeloma 30132507 Serum miR-30d as a novel biomarker for multiple myeloma and its antitumor role in U266 cells through the targeting of the MTDH/PI3K/Akt signaling pathway. -circulation_biomarker_diagnosis_ns hsa-mir-1260a Melanoma 30132912 Differential expression of miR-150-5p and miR-1260a is present in plasma following surgical resection of metastatic melanoma in this small sample (n?=?6) of melanoma patients -circulation_biomarker_diagnosis_ns hsa-mir-150 Melanoma 30132912 Differential expression of miR-150-5p and miR-1260a is present in plasma following surgical resection of metastatic melanoma in this small sample (n?=?6) of melanoma patients -circulation_biomarker_diagnosis_ns hsa-mir-106 Hepatitis C Virus Infection 30133717 "miR-23b and miR-106 might be a useful biomarker for chronic hepatitis C (CHC). MiR-27a, miR-93, and miR-199 might have a potential role in the progression of liver diseases" -circulation_biomarker_diagnosis_ns hsa-mir-23b Hepatitis C Virus Infection 30133717 "miR-23b and miR-106 might be a useful biomarker for chronic hepatitis C (CHC). MiR-27a, miR-93, and miR-199 might have a potential role in the progression of liver diseases" -circulation_biomarker_diagnosis_ns hsa-let-7b "Leukemia, Lymphoblastic, Acute" 30139235 Expression of Micro-RNA 128 and Let-7b in Pediatric Acute Lymphoblastic Leukemia Cases -circulation_biomarker_diagnosis_ns hsa-mir-128 "Leukemia, Lymphoblastic, Acute" 30139235 Expression of Micro-RNA 128 and Let-7b in Pediatric Acute Lymphoblastic Leukemia Cases -circulation_biomarker_diagnosis_ns hsa-mir-125b Graft-Versus-Host Disease 30142940 "we selected the 10 miRNAs (miR-423-5p, miR-19a, miR-142-3p, miR-128, miR-193b, miR-30c, miR-193a, miR-191, miR-125b, and miR-574-3p) with the most significant differential expression" -circulation_biomarker_diagnosis_ns hsa-mir-128 Graft-Versus-Host Disease 30142940 "we selected the 10 miRNAs (miR-423-5p, miR-19a, miR-142-3p, miR-128, miR-193b, miR-30c, miR-193a, miR-191, miR-125b, and miR-574-3p) with the most significant differential expression" -circulation_biomarker_diagnosis_ns hsa-mir-142 Graft-Versus-Host Disease 30142940 "we selected the 10 miRNAs (miR-423-5p, miR-19a, miR-142-3p, miR-128, miR-193b, miR-30c, miR-193a, miR-191, miR-125b, and miR-574-3p) with the most significant differential expression" -circulation_biomarker_diagnosis_ns hsa-mir-191 Graft-Versus-Host Disease 30142940 "we selected the 10 miRNAs (miR-423-5p, miR-19a, miR-142-3p, miR-128, miR-193b, miR-30c, miR-193a, miR-191, miR-125b, and miR-574-3p) with the most significant differential expression" -circulation_biomarker_diagnosis_ns hsa-mir-193a Graft-Versus-Host Disease 30142940 "we selected the 10 miRNAs (miR-423-5p, miR-19a, miR-142-3p, miR-128, miR-193b, miR-30c, miR-193a, miR-191, miR-125b, and miR-574-3p) with the most significant differential expression" -circulation_biomarker_diagnosis_ns hsa-mir-193b Graft-Versus-Host Disease 30142940 "we selected the 10 miRNAs (miR-423-5p, miR-19a, miR-142-3p, miR-128, miR-193b, miR-30c, miR-193a, miR-191, miR-125b, and miR-574-3p) with the most significant differential expression" -circulation_biomarker_diagnosis_ns hsa-mir-19a Graft-Versus-Host Disease 30142940 "we selected the 10 miRNAs (miR-423-5p, miR-19a, miR-142-3p, miR-128, miR-193b, miR-30c, miR-193a, miR-191, miR-125b, and miR-574-3p) with the most significant differential expression" -circulation_biomarker_diagnosis_ns hsa-mir-30c Graft-Versus-Host Disease 30142940 "we selected the 10 miRNAs (miR-423-5p, miR-19a, miR-142-3p, miR-128, miR-193b, miR-30c, miR-193a, miR-191, miR-125b, and miR-574-3p) with the most significant differential expression" -circulation_biomarker_diagnosis_ns hsa-mir-423 Graft-Versus-Host Disease 30142940 "we selected the 10 miRNAs (miR-423-5p, miR-19a, miR-142-3p, miR-128, miR-193b, miR-30c, miR-193a, miR-191, miR-125b, and miR-574-3p) with the most significant differential expression" -circulation_biomarker_diagnosis_ns hsa-mir-574 Graft-Versus-Host Disease 30142940 "we selected the 10 miRNAs (miR-423-5p, miR-19a, miR-142-3p, miR-128, miR-193b, miR-30c, miR-193a, miR-191, miR-125b, and miR-574-3p) with the most significant differential expression" -circulation_biomarker_diagnosis_ns hsa-mir-144 Coronary Artery Disease 30143484 Altered Plasma miR-144 as a Novel Biomarker for Coronary Artery Disease. -circulation_biomarker_diagnosis_ns hsa-mir-12 Viral Infectious Disease 30146762 "To date, numerous biomarkers have been identified for thediagnostic or prognostic purpose; for instance, miR-182, miR-486, and miR15a in sepsis; miR-320 and miR505 in inflammatory bowel disease; miR-155 and miR-1260 in influenza; miR-12, miRVP-3p, and miR-184 in arboviruses; and miR-29b and miR-125 in hepatitis infection" -circulation_biomarker_diagnosis_ns hsa-mir-125 Hepatitis [unspecific] 30146762 "To date, numerous biomarkers have been identified for thediagnostic or prognostic purpose; for instance, miR-182, miR-486, and miR15a in sepsis; miR-320 and miR505 in inflammatory bowel disease; miR-155 and miR-1260 in influenza; miR-12, miRVP-3p, and miR-184 in arboviruses; and miR-29b and miR-125 in hepatitis infection" -circulation_biomarker_diagnosis_ns hsa-mir-1260 Influenza 30146762 "To date, numerous biomarkers have been identified for thediagnostic or prognostic purpose; for instance, miR-182, miR-486, and miR15a in sepsis; miR-320 and miR505 in inflammatory bowel disease; miR-155 and miR-1260 in influenza; miR-12, miRVP-3p, and miR-184 in arboviruses; and miR-29b and miR-125 in hepatitis infection" -circulation_biomarker_diagnosis_ns hsa-mir-155 Influenza 30146762 "To date, numerous biomarkers have been identified for thediagnostic or prognostic purpose; for instance, miR-182, miR-486, and miR15a in sepsis; miR-320 and miR505 in inflammatory bowel disease; miR-155 and miR-1260 in influenza; miR-12, miRVP-3p, and miR-184 in arboviruses; and miR-29b and miR-125 in hepatitis infection" -circulation_biomarker_diagnosis_ns hsa-mir-15a Sepsis 30146762 "To date, numerous biomarkers have been identified for thediagnostic or prognostic purpose; for instance, miR-182, miR-486, and miR15a in sepsis; miR-320 and miR505 in inflammatory bowel disease; miR-155 and miR-1260 in influenza; miR-12, miRVP-3p, and miR-184 in arboviruses; and miR-29b and miR-125 in hepatitis infection" -circulation_biomarker_diagnosis_ns hsa-mir-182 Sepsis 30146762 "To date, numerous biomarkers have been identified for thediagnostic or prognostic purpose; for instance, miR-182, miR-486, and miR15a in sepsis; miR-320 and miR505 in inflammatory bowel disease; miR-155 and miR-1260 in influenza; miR-12, miRVP-3p, and miR-184 in arboviruses; and miR-29b and miR-125 in hepatitis infection" -circulation_biomarker_diagnosis_ns hsa-mir-184 Viral Infectious Disease 30146762 "To date, numerous biomarkers have been identified for thediagnostic or prognostic purpose; for instance, miR-182, miR-486, and miR15a in sepsis; miR-320 and miR505 in inflammatory bowel disease; miR-155 and miR-1260 in influenza; miR-12, miRVP-3p, and miR-184 in arboviruses; and miR-29b and miR-125 in hepatitis infection" -circulation_biomarker_diagnosis_ns hsa-mir-29b Hepatitis [unspecific] 30146762 "To date, numerous biomarkers have been identified for thediagnostic or prognostic purpose; for instance, miR-182, miR-486, and miR15a in sepsis; miR-320 and miR505 in inflammatory bowel disease; miR-155 and miR-1260 in influenza; miR-12, miRVP-3p, and miR-184 in arboviruses; and miR-29b and miR-125 in hepatitis infection" -circulation_biomarker_diagnosis_ns hsa-mir-320 Inflammatory Bowel Diseases 30146762 "To date, numerous biomarkers have been identified for thediagnostic or prognostic purpose; for instance, miR-182, miR-486, and miR15a in sepsis; miR-320 and miR505 in inflammatory bowel disease; miR-155 and miR-1260 in influenza; miR-12, miRVP-3p, and miR-184 in arboviruses; and miR-29b and miR-125 in hepatitis infection" -circulation_biomarker_diagnosis_ns hsa-mir-486 Sepsis 30146762 "To date, numerous biomarkers have been identified for thediagnostic or prognostic purpose; for instance, miR-182, miR-486, and miR15a in sepsis; miR-320 and miR505 in inflammatory bowel disease; miR-155 and miR-1260 in influenza; miR-12, miRVP-3p, and miR-184 in arboviruses; and miR-29b and miR-125 in hepatitis infection" -circulation_biomarker_diagnosis_ns hsa-mir-505 Inflammatory Bowel Diseases 30146762 "To date, numerous biomarkers have been identified for thediagnostic or prognostic purpose; for instance, miR-182, miR-486, and miR15a in sepsis; miR-320 and miR505 in inflammatory bowel disease; miR-155 and miR-1260 in influenza; miR-12, miRVP-3p, and miR-184 in arboviruses; and miR-29b and miR-125 in hepatitis infection" -circulation_biomarker_diagnosis_ns hsa-mir-140 Osteoporosis 30171938 Serum miRNAs miR-140-3p and miR-23b-3p as potential biomarkers for osteoporosis and osteoporotic fracture in postmenopausal Mexican-Mestizo women. -circulation_biomarker_diagnosis_ns hsa-mir-23b Osteoporosis 30171938 Serum miRNAs miR-140-3p and miR-23b-3p as potential biomarkers for osteoporosis and osteoporotic fracture in postmenopausal Mexican-Mestizo women. -circulation_biomarker_diagnosis_ns hsa-let-7b Atherosclerosis 30178428 "miR-125b, miR-125a, let-7b, and let-7e could discriminate CARD patients from normal controls and other subtypes. Furthermore, ROC curves shown that miR-7-2-3p and miR-1908 showed significant area-under-the-curve values in both LAA and LAC patients" -circulation_biomarker_diagnosis_ns hsa-let-7e Atherosclerosis 30178428 "miR-125b, miR-125a, let-7b, and let-7e could discriminate CARD patients from normal controls and other subtypes. Furthermore, ROC curves shown that miR-7-2-3p and miR-1908 showed significant area-under-the-curve values in both LAA and LAC patients" -circulation_biomarker_diagnosis_ns hsa-mir-125a Atherosclerosis 30178428 "miR-125b, miR-125a, let-7b, and let-7e could discriminate CARD patients from normal controls and other subtypes. Furthermore, ROC curves shown that miR-7-2-3p and miR-1908 showed significant area-under-the-curve values in both LAA and LAC patients" -circulation_biomarker_diagnosis_ns hsa-mir-125b Atherosclerosis 30178428 "miR-125b, miR-125a, let-7b, and let-7e could discriminate CARD patients from normal controls and other subtypes. Furthermore, ROC curves shown that miR-7-2-3p and miR-1908 showed significant area-under-the-curve values in both LAA and LAC patients" -circulation_biomarker_diagnosis_ns hsa-mir-1908 Atherosclerosis 30178428 "miR-125b, miR-125a, let-7b, and let-7e could discriminate CARD patients from normal controls and other subtypes. Furthermore, ROC curves shown that miR-7-2-3p and miR-1908 showed significant area-under-the-curve values in both LAA and LAC patients" -circulation_biomarker_diagnosis_ns hsa-mir-7-2 Atherosclerosis 30178428 "miR-125b, miR-125a, let-7b, and let-7e could discriminate CARD patients from normal controls and other subtypes. Furthermore, ROC curves shown that miR-7-2-3p and miR-1908 showed significant area-under-the-curve values in both LAA and LAC patients" -circulation_biomarker_diagnosis_ns hsa-mir-376 Preeclampsia 30186390 Expression of miR-376 in blood of pregnant women with preeclampsia and its effect on 25-hydroxyvitamin D. -circulation_biomarker_diagnosis_ns hsa-mir-134 Kawasaki Syndrome 30186482 "Serum exosomal miR-328, miR-575, miR-134 and miR-671-5p as potential biomarkers for the diagnosis of Kawasaki disease and the prediction of therapeutic outcomes of intravenous immunoglobulin therapy." -circulation_biomarker_diagnosis_ns hsa-mir-328 Kawasaki Syndrome 30186482 "Serum exosomal miR-328, miR-575, miR-134 and miR-671-5p as potential biomarkers for the diagnosis of Kawasaki disease and the prediction of therapeutic outcomes of intravenous immunoglobulin therapy." -circulation_biomarker_diagnosis_ns hsa-mir-575 Kawasaki Syndrome 30186482 "Serum exosomal miR-328, miR-575, miR-134 and miR-671-5p as potential biomarkers for the diagnosis of Kawasaki disease and the prediction of therapeutic outcomes of intravenous immunoglobulin therapy." -circulation_biomarker_diagnosis_ns hsa-mir-671 Kawasaki Syndrome 30186482 "Serum exosomal miR-328, miR-575, miR-134 and miR-671-5p as potential biomarkers for the diagnosis of Kawasaki disease and the prediction of therapeutic outcomes of intravenous immunoglobulin therapy." -circulation_biomarker_diagnosis_ns hsa-mir-103a "Carcinoma, Breast" 30220214 miR-24 and miR-103a were valuable biomarkers for distinguishing AH and early-stage BC from healthy individuals/benign proliferative tumor patients -circulation_biomarker_diagnosis_ns hsa-mir-24 "Carcinoma, Breast" 30220214 miR-24 and miR-103a were valuable biomarkers for distinguishing AH and early-stage BC from healthy individuals/benign proliferative tumor patients -circulation_biomarker_diagnosis_ns hsa-mir-331 "Adenocarcinoma, Esophageal" 30228315 Serum miR-331-3p predicts tumor recurrence in esophageal adenocarcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-126 Glioma 30233327 "Many microRNAs (miRNAs) such as miR-183, miR-9, miR-137 and miR-126 expression change may be involved in the cross talk between glioma prevalence and schizophrenia" -circulation_biomarker_diagnosis_ns hsa-mir-126 Schizophrenia 30233327 "Many microRNAs (miRNAs) such as miR-183, miR-9, miR-137 and miR-126 expression change may be involved in the cross talk between glioma prevalence and schizophrenia" -circulation_biomarker_diagnosis_ns hsa-mir-137 Glioma 30233327 "Many microRNAs (miRNAs) such as miR-183, miR-9, miR-137 and miR-126 expression change may be involved in the cross talk between glioma prevalence and schizophrenia" -circulation_biomarker_diagnosis_ns hsa-mir-137 Schizophrenia 30233327 "Many microRNAs (miRNAs) such as miR-183, miR-9, miR-137 and miR-126 expression change may be involved in the cross talk between glioma prevalence and schizophrenia" -circulation_biomarker_diagnosis_ns hsa-mir-183 Glioma 30233327 "Many microRNAs (miRNAs) such as miR-183, miR-9, miR-137 and miR-126 expression change may be involved in the cross talk between glioma prevalence and schizophrenia" -circulation_biomarker_diagnosis_ns hsa-mir-183 Schizophrenia 30233327 "Many microRNAs (miRNAs) such as miR-183, miR-9, miR-137 and miR-126 expression change may be involved in the cross talk between glioma prevalence and schizophrenia" -circulation_biomarker_diagnosis_ns hsa-mir-9 Glioma 30233327 "Many microRNAs (miRNAs) such as miR-183, miR-9, miR-137 and miR-126 expression change may be involved in the cross talk between glioma prevalence and schizophrenia" -circulation_biomarker_diagnosis_ns hsa-mir-9 Schizophrenia 30233327 "Many microRNAs (miRNAs) such as miR-183, miR-9, miR-137 and miR-126 expression change may be involved in the cross talk between glioma prevalence and schizophrenia" -circulation_biomarker_diagnosis_ns hsa-mir-138 Lung Neoplasms 30233883 "We validated a panel of miRNAs (hsa-miR-199a-3p, hsa-miR-148a-3p, hsa-miR-210-3p, hsa-miR-378d and hsa-miR-138-5p) to aid early diagnosis of lung adenocarcinoma by blood test in lung cancer" -circulation_biomarker_diagnosis_ns hsa-mir-148a Lung Neoplasms 30233883 "We validated a panel of miRNAs (hsa-miR-199a-3p, hsa-miR-148a-3p, hsa-miR-210-3p, hsa-miR-378d and hsa-miR-138-5p) to aid early diagnosis of lung adenocarcinoma by blood test in lung cancer" -circulation_biomarker_diagnosis_ns hsa-mir-199a Lung Neoplasms 30233883 "We validated a panel of miRNAs (hsa-miR-199a-3p, hsa-miR-148a-3p, hsa-miR-210-3p, hsa-miR-378d and hsa-miR-138-5p) to aid early diagnosis of lung adenocarcinoma by blood test in lung cancer" -circulation_biomarker_diagnosis_ns hsa-mir-210 Lung Neoplasms 30233883 "We validated a panel of miRNAs (hsa-miR-199a-3p, hsa-miR-148a-3p, hsa-miR-210-3p, hsa-miR-378d and hsa-miR-138-5p) to aid early diagnosis of lung adenocarcinoma by blood test in lung cancer" -circulation_biomarker_diagnosis_ns hsa-mir-378d Lung Neoplasms 30233883 "We validated a panel of miRNAs (hsa-miR-199a-3p, hsa-miR-148a-3p, hsa-miR-210-3p, hsa-miR-378d and hsa-miR-138-5p) to aid early diagnosis of lung adenocarcinoma by blood test in lung cancer" -circulation_biomarker_diagnosis_ns hsa-mir-192 Diabetes Mellitus 30250222 Circulating microRNAs -192 and -194 are associated with the presence and incidence of diabetes mellitus. -circulation_biomarker_diagnosis_ns hsa-mir-194 Diabetes Mellitus 30250222 Circulating microRNAs -192 and -194 are associated with the presence and incidence of diabetes mellitus. -circulation_biomarker_diagnosis_ns hsa-mir-223 Prostate Neoplasms 30250541 Monitoring of platelet function parameters and microRNA expression levels in patients with prostate cancer treated with volumetric modulated arc radiotherapy. -circulation_biomarker_diagnosis_ns hsa-mir-122 "Fatty Liver, Non-Alcoholic" 30252499 "The liver-specific microRNAs including miR-122, miR-130,miR-183, miR-196, miR-209 and miR-96 are potential indicators of liver injury" -circulation_biomarker_diagnosis_ns hsa-mir-130 "Fatty Liver, Non-Alcoholic" 30252499 "The liver-specific microRNAs including miR-122, miR-130,miR-183, miR-196, miR-209 and miR-96 are potential indicators of liver injury" -circulation_biomarker_diagnosis_ns hsa-mir-183 "Fatty Liver, Non-Alcoholic" 30252499 "The liver-specific microRNAs including miR-122, miR-130,miR-183, miR-196, miR-209 and miR-96 are potential indicators of liver injury" -circulation_biomarker_diagnosis_ns hsa-mir-196 "Fatty Liver, Non-Alcoholic" 30252499 "The liver-specific microRNAs including miR-122, miR-130,miR-183, miR-196, miR-209 and miR-96 are potential indicators of liver injury" -circulation_biomarker_diagnosis_ns hsa-mir-209 "Fatty Liver, Non-Alcoholic" 30252499 "The liver-specific microRNAs including miR-122, miR-130,miR-183, miR-196, miR-209 and miR-96 are potential indicators of liver injury" -circulation_biomarker_diagnosis_ns hsa-mir-96 "Fatty Liver, Non-Alcoholic" 30252499 "The liver-specific microRNAs including miR-122, miR-130,miR-183, miR-196, miR-209 and miR-96 are potential indicators of liver injury" -circulation_biomarker_diagnosis_ns hsa-mir-183 "Carcinoma, Hepatocellular" 30256056 Expression Analysis of Serum microRNA-34a and microRNA-183 in Hepatocellular Carcinoma -circulation_biomarker_diagnosis_ns hsa-mir-34a "Carcinoma, Hepatocellular" 30256056 Expression Analysis of Serum microRNA-34a and microRNA-183 in Hepatocellular Carcinoma -circulation_biomarker_diagnosis_ns hsa-mir-22 Myocardial Infarction 30256407 Circulating miR-22-5p and miR-122-5p are promising novel biomarkers for diagnosis of acute myocardial infarction. -circulation_biomarker_diagnosis_ns hsa-mir-22 Myocardial Infarction 30256407 Circulating miR-22-5p and miR-122-5p are promising novel biomarkers for diagnosis of acute myocardial infarction. -circulation_biomarker_diagnosis_ns hsa-mir-199a Diabetes Mellitus 30258406 "Diabetes Modulates MicroRNAs 29b-3p, 29c-3p, 199a-5p and 532-3p Expression in Muscle: Possible Role in GLUT4 and HK2 Repression." -circulation_biomarker_diagnosis_ns hsa-mir-29b Diabetes Mellitus 30258406 "Diabetes Modulates MicroRNAs 29b-3p, 29c-3p, 199a-5p and 532-3p Expression in Muscle: Possible Role in GLUT4 and HK2 Repression." -circulation_biomarker_diagnosis_ns hsa-mir-29c Diabetes Mellitus 30258406 "Diabetes Modulates MicroRNAs 29b-3p, 29c-3p, 199a-5p and 532-3p Expression in Muscle: Possible Role in GLUT4 and HK2 Repression." -circulation_biomarker_diagnosis_ns hsa-mir-532 Diabetes Mellitus 30258406 "Diabetes Modulates MicroRNAs 29b-3p, 29c-3p, 199a-5p and 532-3p Expression in Muscle: Possible Role in GLUT4 and HK2 Repression." -circulation_biomarker_diagnosis_ns hsa-let-7g "Diabetes Mellitus, Type 1" 30259606 Temporal dynamics of serum let-7g expression mirror the decline of residual beta-cell function in longitudinal observation of children with type 1 diabetes. -circulation_biomarker_diagnosis_ns hsa-mir-136 Preeclampsia 30261165 "Role of mesenchymal stem cells exosomes derived microRNAs; miR-136, miR-494 and miR-495 in pre-eclampsia diagnosis and evaluation." -circulation_biomarker_diagnosis_ns hsa-mir-494 Preeclampsia 30261165 "Role of mesenchymal stem cells exosomes derived microRNAs; miR-136, miR-494 and miR-495 in pre-eclampsia diagnosis and evaluation." -circulation_biomarker_diagnosis_ns hsa-mir-495 Preeclampsia 30261165 "Role of mesenchymal stem cells exosomes derived microRNAs; miR-136, miR-494 and miR-495 in pre-eclampsia diagnosis and evaluation." -circulation_biomarker_diagnosis_ns hsa-mir-200 Ovarian Neoplasms 30275195 Increased Soluble PD-L1 Levels in the Plasma of Patients with Epithelial Ovarian Cancer Correlate with Plasma Levels of miR34a and miR200. -circulation_biomarker_diagnosis_ns hsa-mir-34a Ovarian Neoplasms 30275195 Increased Soluble PD-L1 Levels in the Plasma of Patients with Epithelial Ovarian Cancer Correlate with Plasma Levels of miR34a and miR200. -circulation_biomarker_diagnosis_ns hsa-mir-142a Myocardial Infarction 30279543 A novel system-level approach using RNA-sequencing data identifies miR-30-5p and miR-142a-5p as key regulators of apoptosis in myocardial infarction. -circulation_biomarker_diagnosis_ns hsa-mir-30 Myocardial Infarction 30279543 A novel system-level approach using RNA-sequencing data identifies miR-30-5p and miR-142a-5p as key regulators of apoptosis in myocardial infarction. -circulation_biomarker_diagnosis_ns hsa-mir-210 "Carcinoma, Renal Cell, Clear-Cell" 30304555 Serum exosomal miR-210 as a potential biomarker for clear cell renal cell carcinoma. -circulation_biomarker_diagnosis_ns hsa-mir-371b Systemic Lupus Erythematosus 30304699 Serum miRNA-371b-5p and miRNA-5100 act as biomarkers for systemic lupus erythematosus. -circulation_biomarker_diagnosis_ns hsa-mir-5100 Systemic Lupus Erythematosus 30304699 Serum miRNA-371b-5p and miRNA-5100 act as biomarkers for systemic lupus erythematosus. -circulation_biomarker_diagnosis_ns hsa-mir-146a Lupus Nephritis 30306067 "miR-3135b, miR-654-5p and miR-146a-5p in urinary exosomes could be used as novel non-invasive diagnostic markers for LNIV-CC" -circulation_biomarker_diagnosis_ns hsa-mir-3135b Lupus Nephritis 30306067 "miR-3135b, miR-654-5p and miR-146a-5p in urinary exosomes could be used as novel non-invasive diagnostic markers for LNIV-CC" -circulation_biomarker_diagnosis_ns hsa-mir-654 Lupus Nephritis 30306067 "miR-3135b, miR-654-5p and miR-146a-5p in urinary exosomes could be used as novel non-invasive diagnostic markers for LNIV-CC" -circulation_biomarker_diagnosis_ns hsa-mir-29c Atherosclerosis 30308507 Plasma MicroRNA-29c Levels Are Associated with Carotid Intima-Media Thickness and is a Potential Biomarker for the Early Detection of Atherosclerosis. -circulation_biomarker_diagnosis_ns hsa-mir-1254 Myocardial Infarction 30310086 Circulating miR-1254 predicts ventricular remodeling in patients with ST-Segment-Elevation Myocardial Infarction: A cardiovascular magnetic resonance study. -circulation_biomarker_diagnosis_ns hsa-mir-142a Alzheimer Disease 30314521 "four of these (miR-142a-5p, miR-146a-5p, miR-155-5p and miR-455-5p) are altered in AD patients" -circulation_biomarker_diagnosis_ns hsa-mir-146a Alzheimer Disease 30314521 "four of these (miR-142a-5p, miR-146a-5p, miR-155-5p and miR-455-5p) are altered in AD patients" -circulation_biomarker_diagnosis_ns hsa-mir-155 Alzheimer Disease 30314521 "four of these (miR-142a-5p, miR-146a-5p, miR-155-5p and miR-455-5p) are altered in AD patients" -circulation_biomarker_diagnosis_ns hsa-mir-455 Alzheimer Disease 30314521 "four of these (miR-142a-5p, miR-146a-5p, miR-155-5p and miR-455-5p) are altered in AD patients" -circulation_biomarker_diagnosis_ns hsa-mir-2166 "Stroke, Ischemic" 30316639 "Ten of these miRNA had not previously been associated with ischemic stroke (miR-664a-3p, -2116-5pp, -4531, -4765-5p, -647, -4709-3p, -4742-3p, -5584-3p, -4756-3p, and -5187-3p)" -circulation_biomarker_diagnosis_ns hsa-mir-4531 "Stroke, Ischemic" 30316639 "Ten of these miRNA had not previously been associated with ischemic stroke (miR-664a-3p, -2116-5pp, -4531, -4765-5p, -647, -4709-3p, -4742-3p, -5584-3p, -4756-3p, and -5187-3p)" -circulation_biomarker_diagnosis_ns hsa-mir-4709 "Stroke, Ischemic" 30316639 "Ten of these miRNA had not previously been associated with ischemic stroke (miR-664a-3p, -2116-5pp, -4531, -4765-5p, -647, -4709-3p, -4742-3p, -5584-3p, -4756-3p, and -5187-3p)" -circulation_biomarker_diagnosis_ns hsa-mir-4742 "Stroke, Ischemic" 30316639 "Ten of these miRNA had not previously been associated with ischemic stroke (miR-664a-3p, -2116-5pp, -4531, -4765-5p, -647, -4709-3p, -4742-3p, -5584-3p, -4756-3p, and -5187-3p)" -circulation_biomarker_diagnosis_ns hsa-mir-4756 "Stroke, Ischemic" 30316639 "Ten of these miRNA had not previously been associated with ischemic stroke (miR-664a-3p, -2116-5pp, -4531, -4765-5p, -647, -4709-3p, -4742-3p, -5584-3p, -4756-3p, and -5187-3p)" -circulation_biomarker_diagnosis_ns hsa-mir-4765 "Stroke, Ischemic" 30316639 "Ten of these miRNA had not previously been associated with ischemic stroke (miR-664a-3p, -2116-5pp, -4531, -4765-5p, -647, -4709-3p, -4742-3p, -5584-3p, -4756-3p, and -5187-3p)" -circulation_biomarker_diagnosis_ns hsa-mir-5187 "Stroke, Ischemic" 30316639 "Ten of these miRNA had not previously been associated with ischemic stroke (miR-664a-3p, -2116-5pp, -4531, -4765-5p, -647, -4709-3p, -4742-3p, -5584-3p, -4756-3p, and -5187-3p)" -circulation_biomarker_diagnosis_ns hsa-mir-5584 "Stroke, Ischemic" 30316639 "Ten of these miRNA had not previously been associated with ischemic stroke (miR-664a-3p, -2116-5pp, -4531, -4765-5p, -647, -4709-3p, -4742-3p, -5584-3p, -4756-3p, and -5187-3p)" -circulation_biomarker_diagnosis_ns hsa-mir-647 "Stroke, Ischemic" 30316639 "Ten of these miRNA had not previously been associated with ischemic stroke (miR-664a-3p, -2116-5pp, -4531, -4765-5p, -647, -4709-3p, -4742-3p, -5584-3p, -4756-3p, and -5187-3p)" -circulation_biomarker_diagnosis_ns hsa-mir-664a "Stroke, Ischemic" 30316639 "Ten of these miRNA had not previously been associated with ischemic stroke (miR-664a-3p, -2116-5pp, -4531, -4765-5p, -647, -4709-3p, -4742-3p, -5584-3p, -4756-3p, and -5187-3p)" -circulation_biomarker_diagnosis_ns hsa-mir-371a Testicular Germ Cell Tumor 30321995 MiR-371a-3p Serum Levels Are Increased in Recurrence of Testicular Germ Cell Tumor Patients. -circulation_biomarker_diagnosis_ns hsa-mir-210 Preeclampsia 30324123 miR-210 could serve as a novel biomarker to predict PE pathophysiology -circulation_biomarker_diagnosis_ns hsa-let-7b Prostate Neoplasms 30324582 "miR-1825, miR-484, miR-205, miR-141, and let-7b were shown to be highly specific for PCa" -circulation_biomarker_diagnosis_ns hsa-mir-141 Prostate Neoplasms 30324582 "miR-1825, miR-484, miR-205, miR-141, and let-7b were shown to be highly specific for PCa" -circulation_biomarker_diagnosis_ns hsa-mir-1825 Prostate Neoplasms 30324582 "miR-1825, miR-484, miR-205, miR-141, and let-7b were shown to be highly specific for PCa" -circulation_biomarker_diagnosis_ns hsa-mir-205 Prostate Neoplasms 30324582 "miR-1825, miR-484, miR-205, miR-141, and let-7b were shown to be highly specific for PCa" -circulation_biomarker_diagnosis_ns hsa-mir-484 Prostate Neoplasms 30324582 "miR-1825, miR-484, miR-205, miR-141, and let-7b were shown to be highly specific for PCa" -circulation_biomarker_diagnosis_ns hsa-mir-143 Sepsis 30332984 MicroRNAs 143 and 150 in whole blood enable detection of T-cell immunoparalysis in sepsis. -circulation_biomarker_diagnosis_ns hsa-mir-150 Sepsis 30332984 MicroRNAs 143 and 150 in whole blood enable detection of T-cell immunoparalysis in sepsis. -circulation_biomarker_diagnosis_ns hsa-mir-10a Vascular Myelopathy 30352301 "MicroRNA-10a, -210 and -563 as circulating biomarkers for Ossification of the Posterior Longitudinal Ligament." -circulation_biomarker_diagnosis_ns hsa-mir-210 Vascular Myelopathy 30352301 "MicroRNA-10a, -210 and -563 as circulating biomarkers for Ossification of the Posterior Longitudinal Ligament." -circulation_biomarker_diagnosis_ns hsa-mir-563 Vascular Myelopathy 30352301 "MicroRNA-10a, -210 and -563 as circulating biomarkers for Ossification of the Posterior Longitudinal Ligament." -circulation_biomarker_diagnosis_ns hsa-mir-3177 Aneurysmal Subarachnoid Hemorrhage 30354977 whole-blood miRNA levels of hsa-miR-3177-3p could serve as a biomarker for vasospasm -circulation_biomarker_diagnosis_ns hsa-mir-126 Colorectal Carcinoma 30357530 "Role of miRNA-210, miRNA-21 and miRNA-126 as diagnostic biomarkers in colorectal carcinoma: impact of HIF-1¦Á-VEGF signaling pathway." -circulation_biomarker_diagnosis_ns hsa-mir-21 Colorectal Carcinoma 30357530 "Role of miRNA-210, miRNA-21 and miRNA-126 as diagnostic biomarkers in colorectal carcinoma: impact of HIF-1¦Á-VEGF signaling pathway." -circulation_biomarker_diagnosis_ns hsa-mir-210 Colorectal Carcinoma 30357530 "Role of miRNA-210, miRNA-21 and miRNA-126 as diagnostic biomarkers in colorectal carcinoma: impact of HIF-1¦Á-VEGF signaling pathway." -circulation_biomarker_diagnosis_ns hsa-mir-128 Huntington Disease 30359470 "hsa-miR-338-3p, hsa-miR-128-3p, hsa-miR-23a-3p and hsa-miR-24-3p are potential HD-biomarkers" -circulation_biomarker_diagnosis_ns hsa-mir-23a Huntington Disease 30359470 "hsa-miR-338-3p, hsa-miR-128-3p, hsa-miR-23a-3p and hsa-miR-24-3p are potential HD-biomarkers" -circulation_biomarker_diagnosis_ns hsa-mir-24 Huntington Disease 30359470 "hsa-miR-338-3p, hsa-miR-128-3p, hsa-miR-23a-3p and hsa-miR-24-3p are potential HD-biomarkers" -circulation_biomarker_diagnosis_ns hsa-mir-338 Huntington Disease 30359470 "hsa-miR-338-3p, hsa-miR-128-3p, hsa-miR-23a-3p and hsa-miR-24-3p are potential HD-biomarkers" -circulation_biomarker_diagnosis_ns hsa-mir-122 Gastric Neoplasms 30364858 miR-122-5p as a novel biomarker for alpha-fetoprotein-producing gastric cancer. -circulation_biomarker_diagnosis_ns hsa-mir-142 Gastric Neoplasms 30373600 miR-338-3p and miR-142-3p may be promising predictive biomarkers for such patients -circulation_biomarker_diagnosis_ns hsa-mir-338 Gastric Neoplasms 30373600 miR-338-3p and miR-142-3p may be promising predictive biomarkers for such patients -circulation_biomarker_diagnosis_ns hsa-mir-1185-1 "Carcinoma, Bladder" 30382619 Circulating miRNA Panels for Specific and Early Detection in Bladder Cancer. -circulation_biomarker_diagnosis_ns hsa-mir-1343 "Carcinoma, Bladder" 30382619 Circulating miRNA Panels for Specific and Early Detection in Bladder Cancer. -circulation_biomarker_diagnosis_ns hsa-mir-3960 "Carcinoma, Bladder" 30382619 Circulating miRNA Panels for Specific and Early Detection in Bladder Cancer. -circulation_biomarker_diagnosis_ns hsa-mir-4695 "Carcinoma, Bladder" 30382619 Circulating miRNA Panels for Specific and Early Detection in Bladder Cancer. -circulation_biomarker_diagnosis_ns hsa-mir-6087 "Carcinoma, Bladder" 30382619 Circulating miRNA Panels for Specific and Early Detection in Bladder Cancer. -circulation_biomarker_diagnosis_ns hsa-mir-6724 "Carcinoma, Bladder" 30382619 Circulating miRNA Panels for Specific and Early Detection in Bladder Cancer. -circulation_biomarker_diagnosis_ns hsa-mir-6831 "Carcinoma, Bladder" 30382619 Circulating miRNA Panels for Specific and Early Detection in Bladder Cancer. -circulation_biomarker_diagnosis_up hsa-mir-155 "Lymphoma, Burkitt" 14695998 upregulated -circulation_biomarker_diagnosis_up hsa-mir-155 "Lymphoma, B-Cell" 15738415 upregulated -circulation_biomarker_diagnosis_up hsa-mir-155 "Lymphoma, Burkitt" 16195701 overexpression -circulation_biomarker_diagnosis_up hsa-mir-17 "Leukemia, B-Cell" 16224045 Overexpression -circulation_biomarker_diagnosis_up hsa-mir-18a "Leukemia, B-Cell" 16224045 Overexpression -circulation_biomarker_diagnosis_up hsa-mir-19a "Leukemia, B-Cell" 16224045 Overexpression -circulation_biomarker_diagnosis_up hsa-mir-19b-1 "Leukemia, B-Cell" 16224045 Overexpression -circulation_biomarker_diagnosis_up hsa-mir-20a "Leukemia, B-Cell" 16224045 Overexpression -circulation_biomarker_diagnosis_up hsa-mir-92a-1 "Leukemia, B-Cell" 16224045 Overexpression -circulation_biomarker_diagnosis_up hsa-mir-146a "Leukemia, Lymphocytic, Chronic, B-Cell" 16251535 overexpression -circulation_biomarker_diagnosis_up hsa-mir-146b "Leukemia, Lymphocytic, Chronic, B-Cell" 16251535 overexpression -circulation_biomarker_diagnosis_up hsa-mir-155 "Leukemia, Lymphocytic, Chronic, B-Cell" 16251535 overexpression -circulation_biomarker_diagnosis_up hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 16251535 overexpression -circulation_biomarker_diagnosis_up hsa-mir-195 "Leukemia, Lymphocytic, Chronic, B-Cell" 16251535 overexpression -circulation_biomarker_diagnosis_up hsa-mir-221 "Leukemia, Lymphocytic, Chronic, B-Cell" 16251535 overexpression -circulation_biomarker_diagnosis_up hsa-mir-23b "Leukemia, Lymphocytic, Chronic, B-Cell" 16251535 overexpression -circulation_biomarker_diagnosis_up hsa-mir-24-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 16251535 overexpression -circulation_biomarker_diagnosis_up hsa-mir-17 Lung Neoplasms 16266980 overexpressed -circulation_biomarker_diagnosis_up hsa-mir-18a Lung Neoplasms 16266980 overexpressed -circulation_biomarker_diagnosis_up hsa-mir-19a Lung Neoplasms 16266980 overexpressed -circulation_biomarker_diagnosis_up hsa-mir-19b-1 Lung Neoplasms 16266980 overexpressed -circulation_biomarker_diagnosis_up hsa-mir-20a Lung Neoplasms 16266980 overexpressed -circulation_biomarker_diagnosis_up hsa-mir-92a-1 Lung Neoplasms 16266980 overexpressed -circulation_biomarker_diagnosis_up hsa-mir-155 Breast Neoplasms 16466964 overexpressed -circulation_biomarker_diagnosis_up hsa-mir-155 "Leukemia, B-Cell" 16466964 overexpressed -circulation_biomarker_diagnosis_up hsa-mir-155 "Lymphoma, Burkitt" 16466964 overexpressed -circulation_biomarker_diagnosis_up hsa-mir-155 "Lymphoma, Hodgkin" 16466964 overexpressed -circulation_biomarker_diagnosis_up hsa-mir-21 Brain Neoplasms 16466964 overexpressed -circulation_biomarker_diagnosis_up hsa-mir-21 Glioblastoma 16466964 overexpressed -circulation_biomarker_diagnosis_up hsa-mir-155 "Leukemia, B-Cell" 16736018 upregulation of miR-155 and the miR-17-92 cluster -circulation_biomarker_diagnosis_up hsa-mir-17 "Leukemia, B-Cell" 16736018 upregulation of miR-155 and the miR-17-92 cluster -circulation_biomarker_diagnosis_up hsa-mir-18a "Leukemia, B-Cell" 16736018 upregulation of miR-155 and the miR-17-92 cluster -circulation_biomarker_diagnosis_up hsa-mir-19a "Leukemia, B-Cell" 16736018 upregulation of miR-155 and the miR-17-92 cluster -circulation_biomarker_diagnosis_up hsa-mir-19b-1 "Leukemia, B-Cell" 16736018 upregulation of miR-155 and the miR-17-92 cluster -circulation_biomarker_diagnosis_up hsa-mir-20a "Leukemia, B-Cell" 16736018 upregulation of miR-155 and the miR-17-92 cluster -circulation_biomarker_diagnosis_up hsa-mir-92a-1 "Leukemia, B-Cell" 16736018 upregulation of miR-155 and the miR-17-92 cluster -circulation_biomarker_diagnosis_up hsa-mir-127 Breast Neoplasms 16766263 upregulation -circulation_biomarker_diagnosis_up hsa-mir-145 Colon Neoplasms 16885332 Reduced accumulation in colon adenomas and carcinomas -circulation_biomarker_diagnosis_up hsa-mir-146a Thyroid Neoplasms 16885332 up-regulation -circulation_biomarker_diagnosis_up hsa-mir-146b Thyroid Neoplasms 16885332 up-regulation -circulation_biomarker_diagnosis_up hsa-mir-155 Breast Neoplasms 16885332 Overexpression in breast cancers -circulation_biomarker_diagnosis_up hsa-mir-17 Lung Neoplasms 16885332 Overexpressed in lung cancers -circulation_biomarker_diagnosis_up hsa-mir-17 Lymphoma 16885332 Primary transcripts overexpressed in lymphomas -circulation_biomarker_diagnosis_up hsa-mir-18a Lung Neoplasms 16885332 Overexpressed in lung cancers -circulation_biomarker_diagnosis_up hsa-mir-18a Lymphoma 16885332 Primary transcripts overexpressed in lymphomas -circulation_biomarker_diagnosis_up hsa-mir-19a Lung Neoplasms 16885332 Overexpressed in lung cancers -circulation_biomarker_diagnosis_up hsa-mir-19a Lymphoma 16885332 Primary transcripts overexpressed in lymphomas -circulation_biomarker_diagnosis_up hsa-mir-19b-1 Lung Neoplasms 16885332 Overexpressed in lung cancers -circulation_biomarker_diagnosis_up hsa-mir-19b-1 Lymphoma 16885332 Primary transcripts overexpressed in lymphomas -circulation_biomarker_diagnosis_up hsa-mir-20a Lung Neoplasms 16885332 Overexpressed in lung cancers -circulation_biomarker_diagnosis_up hsa-mir-20a Lymphoma 16885332 Primary transcripts overexpressed in lymphomas -circulation_biomarker_diagnosis_up hsa-mir-21 Breast Neoplasms 16885332 Overexpression in breast cancers -circulation_biomarker_diagnosis_up hsa-mir-21 Glioblastoma 16885332 Elevated levels in glioblastoma primary tumors and cell lines -circulation_biomarker_diagnosis_up hsa-mir-221 Thyroid Neoplasms 16885332 "It was shown that miR-221, highly overexpressed in papillary thyroid tumors, is also overexpressed in normal thyroid tissue adjacent to tumors but not in normal thyroid tissues from individuals without clinical thyroid disease." -circulation_biomarker_diagnosis_up hsa-mir-222 Thyroid Neoplasms 16885332 up-regulation -circulation_biomarker_diagnosis_up hsa-mir-92a-1 Lung Neoplasms 16885332 Overexpressed in lung cancers -circulation_biomarker_diagnosis_up hsa-mir-92a-1 Lymphoma 16885332 Primary transcripts overexpressed in lymphomas -circulation_biomarker_diagnosis_up hsa-mir-155 "Lymphoma, Burkitt" 16940181 Increased expression of the precursor of Mir-155has been detected in pediatric Burkitt lymphoma. -circulation_biomarker_diagnosis_up hsa-mir-21 Glioblastoma 17028302 "miR-21 is strongly overexpressed in this highly malignant brain tumor type, while knockdown of miR-21 in glioblastoma cells by an antisense-oligonucleotide triggered activation of caspases and led to increased apoptotic cell death, suggesting that miR-21 overexpression may contribute to the malignant phenotype by suppressing critical apoptosis-related genes." -circulation_biomarker_diagnosis_up hsa-mir-17 Neoplasms [unspecific] 17060945 overexpressed -circulation_biomarker_diagnosis_up hsa-mir-191 Neoplasms [unspecific] 17060945 overexpressed -circulation_biomarker_diagnosis_up hsa-mir-17 Neoplasms [unspecific] 17189674 "Co-expression of a cluster of miRNAs derived from one genomic locus (miR-17, -18, -19, and -20) caused a significant acceleration of tumorigenesis in a c-Myc driven mouse model of lymphomagenesis. The miR-17 cluster for instance was found to be highly expressed in follicular lymphoma, low grade B cell malignancy , several types of lymphoma and solid tumors and small cell lung cancer." -circulation_biomarker_diagnosis_up hsa-mir-18a Neoplasms [unspecific] 17189674 "Co-expression of a cluster of miRNAs derived from one genomic locus (miR-17, -18, -19, and -20) caused a significant acceleration of tumorigenesis in a c-Myc driven mouse model of lymphomagenesis. The miR-17§Ò§ÙC19 cluster for instance was found to be highly expressed in follicular lymphoma, low grade B cell malignancy , several types of lymphoma and solid tumors and small cell lung cancer." -circulation_biomarker_diagnosis_up hsa-mir-18b Neoplasms [unspecific] 17189674 "Co-expression of a cluster of miRNAs derived from one genomic locus (miR-17, -18, -19, and -20) caused a significant acceleration of tumorigenesis in a c-Myc driven mouse model of lymphomagenesis. The miR-17§Ò§ÙC19 cluster for instance was found to be highly expressed in follicular lymphoma, low grade B cell malignancy , several types of lymphoma and solid tumors and small cell lung cancer." -circulation_biomarker_diagnosis_up hsa-mir-19a Neoplasms [unspecific] 17189674 "Co-expression of a cluster of miRNAs derived from one genomic locus (miR-17, -18, -19, and -20) caused a significant acceleration of tumorigenesis in a c-Myc driven mouse model of lymphomagenesis. The miR-17§Ò§ÙC19 cluster for instance was found to be highly expressed in follicular lymphoma, low grade B cell malignancy , several types of lymphoma and solid tumors and small cell lung cancer." -circulation_biomarker_diagnosis_up hsa-mir-19b-1 Neoplasms [unspecific] 17189674 "Co-expression of a cluster of miRNAs derived from one genomic locus (miR-17, -18, -19, and -20) caused a significant acceleration of tumorigenesis in a c-Myc driven mouse model of lymphomagenesis. The miR-17§Ò§ÙC19 cluster for instance was found to be highly expressed in follicular lymphoma, low grade B cell malignancy , several types of lymphoma and solid tumors and small cell lung cancer." -circulation_biomarker_diagnosis_up hsa-mir-19b-2 Neoplasms [unspecific] 17189674 "Co-expression of a cluster of miRNAs derived from one genomic locus (miR-17, -18, -19, and -20) caused a significant acceleration of tumorigenesis in a c-Myc driven mouse model of lymphomagenesis. The miR-17§Ò§ÙC19 cluster for instance was found to be highly expressed in follicular lymphoma, low grade B cell malignancy , several types of lymphoma and solid tumors and small cell lung cancer." -circulation_biomarker_diagnosis_up hsa-mir-20a Neoplasms [unspecific] 17189674 "Co-expression of a cluster of miRNAs derived from one genomic locus (miR-17, -18, -19, and -20) caused a significant acceleration of tumorigenesis in a c-Myc driven mouse model of lymphomagenesis. The miR-17§Ò§ÙC19 cluster for instance was found to be highly expressed in follicular lymphoma, low grade B cell malignancy , several types of lymphoma and solid tumors and small cell lung cancer." -circulation_biomarker_diagnosis_up hsa-mir-20b Neoplasms [unspecific] 17189674 "Co-expression of a cluster of miRNAs derived from one genomic locus (miR-17, -18, -19, and -20) caused a significant acceleration of tumorigenesis in a c-Myc driven mouse model of lymphomagenesis. The miR-17§Ò§ÙC19 cluster for instance was found to be highly expressed in follicular lymphoma, low grade B cell malignancy , several types of lymphoma and solid tumors and small cell lung cancer." -circulation_biomarker_diagnosis_up hsa-mir-372 Testicular Neoplasms 17189674 "The relevance to human tumorigenesis was shown when it was found that these miRNAs are hyper-expressed in Testicular Germ Cell Tumors, a tumor type characterized by its prevalence of wild type p53." -circulation_biomarker_diagnosis_up hsa-mir-373 Testicular Neoplasms 17189674 "The relevance to human tumorigenesis was shown when it was found that these miRNAs are hyper-expressed in Testicular Germ Cell Tumors, a tumor type characterized by its prevalence of wild type p53." -circulation_biomarker_diagnosis_up hsa-let-7a-3 "Leukemia, Promyelocytic, Acute" 17260024 "We found upregulation of miR-15a, miR-15b, miR-16-1, let-7a-3, let-7c, let-7d, miR-223, miR-342 and miR-107, whereas miR-181b was downregulated. Among the upregulated miRNAs, miR-107 is predicted to target NFI-A, a gene that has been involved in a regulatory loop involving miR-223 and C/EBPa during granulocytic differentiation." -circulation_biomarker_diagnosis_up hsa-let-7c "Leukemia, Promyelocytic, Acute" 17260024 "We found upregulation of miR-15a, miR-15b, miR-16-1, let-7a-3, let-7c, let-7d, miR-223, miR-342 and miR-107, whereas miR-181b was downregulated. Among the upregulated miRNAs, miR-107 is predicted to target NFI-A, a gene that has been involved in a regulatory loop involving miR-223 and C/EBPa during granulocytic differentiation." -circulation_biomarker_diagnosis_up hsa-let-7d "Leukemia, Promyelocytic, Acute" 17260024 "We found upregulation of miR-15a, miR-15b, miR-16-1, let-7a-3, let-7c, let-7d, miR-223, miR-342 and miR-107, whereas miR-181b was downregulated. Among the upregulated miRNAs, miR-107 is predicted to target NFI-A, a gene that has been involved in a regulatory loop involving miR-223 and C/EBPa during granulocytic differentiation." -circulation_biomarker_diagnosis_up hsa-mir-107 "Leukemia, Promyelocytic, Acute" 17260024 "We found upregulation of miR-15a, miR-15b, miR-16-1, let-7a-3, let-7c, let-7d, miR-223, miR-342 and miR-107, whereas miR-181b was downregulated. Among the upregulated miRNAs, miR-107 is predicted to target NFI-A, a gene that has been involved in a regulatory loop involving miR-223 and C/EBPa during granulocytic differentiation." -circulation_biomarker_diagnosis_up hsa-mir-15a "Leukemia, Promyelocytic, Acute" 17260024 "We found upregulation of miR-15a, miR-15b, miR-16-1, let-7a-3, let-7c, let-7d, miR-223, miR-342 and miR-107, whereas miR-181b was downregulated. Among the upregulated miRNAs, miR-107 is predicted to target NFI-A, a gene that has been involved in a regulatory loop involving miR-223 and C/EBPa during granulocytic differentiation." -circulation_biomarker_diagnosis_up hsa-mir-15b "Leukemia, Promyelocytic, Acute" 17260024 "We found upregulation of miR-15a, miR-15b, miR-16-1, let-7a-3, let-7c, let-7d, miR-223, miR-342 and miR-107, whereas miR-181b was downregulated. Among the upregulated miRNAs, miR-107 is predicted to target NFI-A, a gene that has been involved in a regulatory loop involving miR-223 and C/EBPa during granulocytic differentiation." -circulation_biomarker_diagnosis_up hsa-mir-16-1 "Leukemia, Promyelocytic, Acute" 17260024 "We found upregulation of miR-15a, miR-15b, miR-16-1, let-7a-3, let-7c, let-7d, miR-223, miR-342 and miR-107, whereas miR-181b was downregulated. Among the upregulated miRNAs, miR-107 is predicted to target NFI-A, a gene that has been involved in a regulatory loop involving miR-223 and C/EBPa during granulocytic differentiation." -circulation_biomarker_diagnosis_up hsa-mir-223 "Leukemia, Promyelocytic, Acute" 17260024 "We found upregulation of miR-15a, miR-15b, miR-16-1, let-7a-3, let-7c, let-7d, miR-223, miR-342 and miR-107, whereas miR-181b was downregulated. Among the upregulated miRNAs, miR-107 is predicted to target NFI-A, a gene that has been involved in a regulatory loop involving miR-223 and C/EBPa during granulocytic differentiation." -circulation_biomarker_diagnosis_up hsa-mir-342 "Leukemia, Promyelocytic, Acute" 17260024 "We found upregulation of miR-15a, miR-15b, miR-16-1, let-7a-3, let-7c, let-7d, miR-223, miR-342 and miR-107, whereas miR-181b was downregulated. Among the upregulated miRNAs, miR-107 is predicted to target NFI-A, a gene that has been involved in a regulatory loop involving miR-223 and C/EBPa during granulocytic differentiation." -circulation_biomarker_diagnosis_up hsa-mir-155 "Leukemia, Lymphocytic, Chronic, B-Cell" 17327404 "Both approaches show that miR-21 and miR-155 are dramatically overexpressed in patients with CLL, although the corresponding genomic loci are not amplified. miR-150 and miR-92 are also significantly deregulated in patients with CLL. In addition, we detected a marked miR-15a and miR-16 decrease in about 11% of cases" -circulation_biomarker_diagnosis_up hsa-mir-21 "Leukemia, Lymphocytic, Chronic, B-Cell" 17327404 "Both approaches show that miR-21 and miR-155 are dramatically overexpressed in patients with CLL, although the corresponding genomic loci are not amplified. miR-150 and miR-92 are also significantly deregulated in patients with CLL. In addition, we detected a marked miR-15a and miR-16 decrease in about 11% of cases" -circulation_biomarker_diagnosis_up hsa-mir-141 Cholangiocarcinoma 17355635 These include miR-200b and miR-141 which have been shown to be highly overexpressed in malignant cholangiocytes and in colon carcinoma. -circulation_biomarker_diagnosis_up hsa-mir-141 Colon Neoplasms 17355635 These include miR-200b and miR-141 which have been shown to be highly overexpressed in malignant cholangiocytes and in colon carcinoma. -circulation_biomarker_diagnosis_up hsa-mir-146a Thyroid Neoplasms 17355635 "Recent studies in miRNA deregulation PTC found an aberrant miRNA expression profile in PTCs compared to normal thyroid tissues. In particular, a significant increase in mir-222, mir-221, mir-146." -circulation_biomarker_diagnosis_up hsa-mir-146b Thyroid Neoplasms 17355635 "Recent studies in miRNA deregulation PTC found an aberrant miRNA expression profile in PTCs compared to normal thyroid tissues. In particular, a significant increase in mir-222, mir-221, mir-146." -circulation_biomarker_diagnosis_up hsa-mir-200a Thyroid Neoplasms 17355635 "Three of these upregulated miRNAs showed significantly higher fold change than the other upregulated miRNAs, these are mir-200a, mir-200b and mir-141." -circulation_biomarker_diagnosis_up hsa-mir-200b Cholangiocarcinoma 17355635 These include miR-200b and miR-141 which have been shown to be highly overexpressed in malignant cholangiocytes and in colon carcinoma. -circulation_biomarker_diagnosis_up hsa-mir-200b Colon Neoplasms 17355635 These include miR-200b and miR-141 which have been shown to be highly overexpressed in malignant cholangiocytes and in colon carcinoma. -circulation_biomarker_diagnosis_up hsa-mir-200b Thyroid Neoplasms 17355635 "Three of these upregulated miRNAs showed significantly higher fold change than the other upregulated miRNAs, these are mir-200a, mir-200b and mir-141." -circulation_biomarker_diagnosis_up hsa-mir-221 Thyroid Neoplasms 17355635 "Recent studies in miRNA deregulation PTC found an aberrant miRNA expression profile in PTCs compared to normal thyroid tissues. In particular, a significant increase in mir-222, mir-221, mir-146." -circulation_biomarker_diagnosis_up hsa-mir-222 Thyroid Neoplasms 17355635 "Recent studies in miRNA deregulation PTC found an aberrant miRNA expression profile in PTCs compared to normal thyroid tissues. In particular, a significant increase in mir-222, mir-221, mir-146." -circulation_biomarker_diagnosis_up hsa-mir-208a Heart Failure 17379774 upregulation -circulation_biomarker_diagnosis_up hsa-mir-106a Colon Neoplasms 17442096 "Indeed, in human solid tumors, mir-106a expression is increased in colon, pancreas, and prostate tumors." -circulation_biomarker_diagnosis_up hsa-mir-106a Pancreatic Neoplasms 17442096 "Indeed, in human solid tumors, mir-106a expression is increased in colon, pancreas, and prostate tumors." -circulation_biomarker_diagnosis_up hsa-mir-106a Prostate Neoplasms 17442096 "Indeed, in human solid tumors, mir-106a expression is increased in colon, pancreas, and prostate tumors." -circulation_biomarker_diagnosis_up hsa-mir-17 Lung Neoplasms 17442096 The mir-17 cluster is also overexpressed in human lung cancer. -circulation_biomarker_diagnosis_up hsa-mir-132 Breast Neoplasms 17447837 "miR-132, previously shown to be differentially upregulated in six solid cancer types (breast, colon, lung, pancreas, prostate, and stomach carcinomas)" -circulation_biomarker_diagnosis_up hsa-mir-132 Colon Neoplasms 17447837 "miR-132, previously shown to be differentially upregulated in six solid cancer types (breast, colon, lung, pancreas, prostate, and stomach carcinomas)" -circulation_biomarker_diagnosis_up hsa-mir-132 Gastric Neoplasms 17447837 "miR-132, previously shown to be differentially upregulated in six solid cancer types (breast, colon, lung, pancreas, prostate, and stomach carcinomas)" -circulation_biomarker_diagnosis_up hsa-mir-132 Lung Neoplasms 17447837 "miR-132, previously shown to be differentially upregulated in six solid cancer types (breast, colon, lung, pancreas, prostate, and stomach carcinomas)" -circulation_biomarker_diagnosis_up hsa-mir-132 Pancreatic Neoplasms 17447837 "miR-132, previously shown to be differentially upregulated in six solid cancer types (breast, colon, lung, pancreas, prostate, and stomach carcinomas)" -circulation_biomarker_diagnosis_up hsa-mir-132 Prostate Neoplasms 17447837 "miR-132, previously shown to be differentially upregulated in six solid cancer types (breast, colon, lung, pancreas, prostate, and stomach carcinomas)" -circulation_biomarker_diagnosis_up hsa-mir-21 Focal Epithelial Hyperplasia 17478730 We found that miR-21 was one of the most upregulated miRNAs in the vascular wall after balloon injury. Our results strongly indicate that miR-21 is an important regulator for neointimal hyperplasia. -circulation_biomarker_diagnosis_up hsa-mir-155 "Lymphoma, Large B-Cell, Diffuse" 17487835 "DLBCL cases over-expressed miR-21, miR-155 and miR-221 by an average of 9.3, 4.6 and 2.3-fold respectively compared to normal peripheral blood B cells." -circulation_biomarker_diagnosis_up hsa-mir-21 "Lymphoma, Large B-Cell, Diffuse" 17487835 "DLBCL cases over-expressed miR-21, miR-155 and miR-221 by an average of 9.3, 4.6 and 2.3-fold respectively compared to normal peripheral blood B cells." -circulation_biomarker_diagnosis_up hsa-mir-221 "Lymphoma, Large B-Cell, Diffuse" 17487835 "DLBCL cases over-expressed miR-21, miR-155 and miR-221 by an average of 9.3, 4.6 and 2.3-fold respectively compared to normal peripheral blood B cells." -circulation_biomarker_diagnosis_up hsa-mir-195 "Cardiomyopathy, Hypertrophic" 17786230 "Cardiac-specific overexpression of miRNA-195 (miR-195), which is consistently upregulated in rodent and human hypertrophic hearts, for example, results in dilated cardiomyopathy and heart failure in mice as early as two weeks of age, implying that upregulation of miR-195 during cardiac hypertrophy actively contributes to the disease process." -circulation_biomarker_diagnosis_up hsa-mir-1-1 Coronary Artery Disease 17919180 elevated expression -circulation_biomarker_diagnosis_up hsa-mir-1-2 Coronary Artery Disease 17919180 elevated expression -circulation_biomarker_diagnosis_up hsa-mir-128b "Leukemia, Lymphoblastic, Acute" 17934639 "The five most highly expressed miRNAs were miR-128b, miR-204, miR-218, miR-331, and miR-181b-1 in ALL, and miR-331, miR-29a, miR-195, miR-34a, and miR-29c in CLL." -circulation_biomarker_diagnosis_up hsa-mir-17 "Leukemia, Lymphoblastic, Acute" 17934639 "The miR-17-92 cluster was also found to be up-regulated in ALL, as previously reported for some types of lymphomas." -circulation_biomarker_diagnosis_up hsa-mir-18 "Leukemia, Lymphoblastic, Acute" 17934639 "The miR-17-92 cluster was also found to be up-regulated in ALL, as previously reported for some types of lymphomas." -circulation_biomarker_diagnosis_up hsa-mir-181b-1 "Leukemia, Lymphoblastic, Acute" 17934639 "The five most highly expressed miRNAs were miR-128b, miR-204, miR-218, miR-331, and miR-181b-1 in ALL, and miR-331, miR-29a, miR-195, miR-34a, and miR-29c in CLL." -circulation_biomarker_diagnosis_up hsa-mir-195 "Leukemia, Lymphocytic, Chronic, B-Cell" 17934639 "The five most highly expressed miRNAs were miR-128b, miR-204, miR-218, miR-331, and miR-181b-1 in ALL, and miR-331, miR-29a, miR-195, miR-34a, and miR-29c in CLL." -circulation_biomarker_diagnosis_up hsa-mir-19a "Leukemia, Lymphoblastic, Acute" 17934639 "The miR-17-92 cluster was also found to be up-regulated in ALL, as previously reported for some types of lymphomas." -circulation_biomarker_diagnosis_up hsa-mir-19b-1 "Leukemia, Lymphoblastic, Acute" 17934639 "The miR-17-92 cluster was also found to be up-regulated in ALL, as previously reported for some types of lymphomas." -circulation_biomarker_diagnosis_up hsa-mir-204 "Leukemia, Lymphoblastic, Acute" 17934639 "The five most highly expressed miRNAs were miR-128b, miR-204, miR-218, miR-331, and miR-181b-1 in ALL, and miR-331, miR-29a, miR-195, miR-34a, and miR-29c in CLL." -circulation_biomarker_diagnosis_up hsa-mir-20a "Leukemia, Lymphoblastic, Acute" 17934639 "The miR-17-92 cluster was also found to be up-regulated in ALL, as previously reported for some types of lymphomas." -circulation_biomarker_diagnosis_up hsa-mir-218 "Leukemia, Lymphoblastic, Acute" 17934639 "The five most highly expressed miRNAs were miR-128b, miR-204, miR-218, miR-331, and miR-181b-1 in ALL, and miR-331, miR-29a, miR-195, miR-34a, and miR-29c in CLL." -circulation_biomarker_diagnosis_up hsa-mir-29a "Leukemia, Lymphocytic, Chronic, B-Cell" 17934639 "The five most highly expressed miRNAs were miR-128b, miR-204, miR-218, miR-331, and miR-181b-1 in ALL, and miR-331, miR-29a, miR-195, miR-34a, and miR-29c in CLL." -circulation_biomarker_diagnosis_up hsa-mir-29c "Leukemia, Lymphocytic, Chronic, B-Cell" 17934639 "The five most highly expressed miRNAs were miR-128b, miR-204, miR-218, miR-331, and miR-181b-1 in ALL, and miR-331, miR-29a, miR-195, miR-34a, and miR-29c in CLL." -circulation_biomarker_diagnosis_up hsa-mir-331 "Leukemia, Lymphoblastic, Acute" 17934639 "The five most highly expressed miRNAs were miR-128b, miR-204, miR-218, miR-331, and miR-181b-1 in ALL, and miR-331, miR-29a, miR-195, miR-34a, and miR-29c in CLL." -circulation_biomarker_diagnosis_up hsa-mir-331 "Leukemia, Lymphocytic, Chronic, B-Cell" 17934639 "The five most highly expressed miRNAs were miR-128b, miR-204, miR-218, miR-331, and miR-181b-1 in ALL, and miR-331, miR-29a, miR-195, miR-34a, and miR-29c in CLL." -circulation_biomarker_diagnosis_up hsa-mir-34a "Leukemia, Lymphocytic, Chronic, B-Cell" 17934639 "The five most highly expressed miRNAs were miR-128b, miR-204, miR-218, miR-331, and miR-181b-1 in ALL, and miR-331, miR-29a, miR-195, miR-34a, and miR-29c in CLL." -circulation_biomarker_diagnosis_up hsa-mir-92-1 "Leukemia, Lymphoblastic, Acute" 17934639 "The miR-17-92 cluster was also found to be up-regulated in ALL, as previously reported for some types of lymphomas." -circulation_biomarker_diagnosis_up hsa-mir-155 "Leukemia, B-Cell" 17940623 "miR-155 is encoded by nucleotides 241-262 of BIC, which was originally identified as a transcript derived from an integration site for the avian leucosis virus and found to be overexpressed in B-cell lymphomas. The role of miR-155 is not restricted to B cell lymphomas, however. Recent studies have reported that miR-155 is upregulated in breast, lung, colon, and thyroid cancers." -circulation_biomarker_diagnosis_up hsa-mir-1-1 "Cardiomyopathy, Hypertrophic" 17965831 "miR-1 is overexpressed in patients with coronary artery disease and that overexpression of miR-1 in a rat model of cardiac infarction exacerbated arrhythmogenesis. Cardiac hypertrophy may also be regulated by miR-1, which is significantly down-regulated in hypertrophic tissue." -circulation_biomarker_diagnosis_up hsa-mir-1-1 Coronary Artery Disease 17965831 "miR-1 is overexpressed in patients with coronary artery disease and that overexpression of miR-1 in a rat model of cardiac infarction exacerbated arrhythmogenesis. Cardiac hypertrophy may also be regulated by miR-1, which is significantly down-regulated in hypertrophic tissue." -circulation_biomarker_diagnosis_up hsa-mir-1-2 "Cardiomyopathy, Hypertrophic" 17965831 "miR-1 is overexpressed in patients with coronary artery disease and that overexpression of miR-1 in a rat model of cardiac infarction exacerbated arrhythmogenesis. Cardiac hypertrophy may also be regulated by miR-1, which is significantly down-regulated in hypertrophic tissue." -circulation_biomarker_diagnosis_up hsa-mir-1-2 Coronary Artery Disease 17965831 "miR-1 is overexpressed in patients with coronary artery disease and that overexpression of miR-1 in a rat model of cardiac infarction exacerbated arrhythmogenesis. Cardiac hypertrophy may also be regulated by miR-1, which is significantly down-regulated in hypertrophic tissue." -circulation_biomarker_diagnosis_up hsa-mir-146a Psoriasis 17965831 miR-146 is also expressed highly in the skin of psoriasis patients. -circulation_biomarker_diagnosis_up hsa-mir-146a Thyroid Neoplasms 17965831 "Numerous miRNAs are also up-regulated in papillary thyroid carcinoma, including miR-221, miR-22 and miR-146. This up-regulation was associated with a downregulation in the expression of the oncogene KIT, a tyrosine kinase important for the control of cell proliferation." -circulation_biomarker_diagnosis_up hsa-mir-146b Psoriasis 17965831 miR-146 is also expressed highly in the skin of psoriasis patients. -circulation_biomarker_diagnosis_up hsa-mir-146b Thyroid Neoplasms 17965831 "Numerous miRNAs are also up-regulated in papillary thyroid carcinoma, including miR-221, miR-22 and miR-146. This up-regulation was associated with a downregulation in the expression of the oncogene KIT, a tyrosine kinase important for the control of cell proliferation." -circulation_biomarker_diagnosis_up hsa-mir-22 Thyroid Neoplasms 17965831 "Numerous miRNAs are also up-regulated in papillary thyroid carcinoma, including miR-221, miR-22 and miR-146. This up-regulation was associated with a downregulation in the expression of the oncogene KIT, a tyrosine kinase important for the control of cell proliferation." -circulation_biomarker_diagnosis_up hsa-mir-221 Thyroid Neoplasms 17965831 "Numerous miRNAs are also up-regulated in papillary thyroid carcinoma, including miR-221, miR-22 and miR-146. This up-regulation was associated with a downregulation in the expression of the oncogene KIT, a tyrosine kinase important for the control of cell proliferation." -circulation_biomarker_diagnosis_up hsa-mir-16-1 Polycythemia Vera 17976518 "Comparative analyses of control and PV EPs suggested increased levels of miR-451, miR-16, miR-21, and miR-26b and decreased levels of miR-150 and miR-221 in PV group, Expression of miR-150 progressively declined with erythroid differentiation, its expression decreased ninefold (p < 0.05) from days 7 to 11." -circulation_biomarker_diagnosis_up hsa-mir-16-2 Polycythemia Vera 17976518 "Comparative analyses of control and PV EPs suggested increased levels of miR-451, miR-16, miR-21, and miR-26b and decreased levels of miR-150 and miR-221 in PV group, Expression of miR-150 progressively declined with erythroid differentiation, its expression decreased ninefold (p < 0.05) from days 7 to 11." -circulation_biomarker_diagnosis_up hsa-mir-21 Polycythemia Vera 17976518 "Comparative analyses of control and PV EPs suggested increased levels of miR-451, miR-16, miR-21, and miR-26b and decreased levels of miR-150 and miR-221 in PV group, Expression of miR-150 progressively declined with erythroid differentiation, its expression decreased ninefold (p < 0.05) from days 7 to 11." -circulation_biomarker_diagnosis_up hsa-mir-26b Polycythemia Vera 17976518 "Comparative analyses of control and PV EPs suggested increased levels of miR-451, miR-16, miR-21, and miR-26b and decreased levels of miR-150 and miR-221 in PV group, Expression of miR-150 progressively declined with erythroid differentiation, its expression decreased ninefold (p < 0.05) from days 7 to 11." -circulation_biomarker_diagnosis_up hsa-mir-451a Polycythemia Vera 17976518 "Comparative analyses of control and PV EPs suggested increased levels of miR-451, miR-16, miR-21, and miR-26b and decreased levels of miR-150 and miR-221 in PV group, Expression of miR-150 progressively declined with erythroid differentiation, its expression decreased ninefold (p < 0.05) from days 7 to 11." -circulation_biomarker_diagnosis_up hsa-mir-128a "Leukemia, Lymphoblastic" 18056805 "Among them, miR-128a and -128b are significantly overexpressed, whereas let-7b and miR-223 are significantly down-regulated in ALL compared with AML." -circulation_biomarker_diagnosis_up hsa-mir-128b "Leukemia, Lymphoblastic" 18056805 "Among them, miR-128a and -128b are significantly overexpressed, whereas let-7b and miR-223 are significantly down-regulated in ALL compared with AML." -circulation_biomarker_diagnosis_up hsa-mir-212 Liver Diseases [unspecific] 18162065 increased -circulation_biomarker_diagnosis_up hsa-mir-21 "Carcinoma, Hepatocellular" 18223217 increased -circulation_biomarker_diagnosis_up hsa-mir-128-2 Lung Neoplasms 18304967 increased -circulation_biomarker_diagnosis_up hsa-mir-150 Lymphoma 18348159 "Three of 15 miRNAs (miR-16, miR-21, and miR-150) showed a high expression level in both blood and lymph node samples. " -circulation_biomarker_diagnosis_up hsa-mir-16 Lymphoma 18348159 "Three of 15 miRNAs (miR-16, miR-21, and miR-150) showed a high expression level in both blood and lymph node samples. " -circulation_biomarker_diagnosis_up hsa-mir-21 Lymphoma 18348159 "Three of 15 miRNAs (miR-16, miR-21, and miR-150) showed a high expression level in both blood and lymph node samples. " -circulation_biomarker_diagnosis_up hsa-mir-146a Eczema Herpeticum 18419608 upregulation -circulation_biomarker_diagnosis_up hsa-mir-143 Polycythemia Vera 18508790 "We observed down-regulation of let-7a and up-regulation of miR-182 in polycythemia vera granulocytes, up-regulation of miR-143, miR-145 and miR-223 in polycythemia vera mononuclear cells, up-regulation of miR-26b in polycythemia vera platelets, and down-regulation of miR-30b, miR-30c and miR-150 in polycythemia vera reticulocytes." -circulation_biomarker_diagnosis_up hsa-mir-145 Polycythemia Vera 18508790 "We observed down-regulation of let-7a and up-regulation of miR-182 in polycythemia vera granulocytes, up-regulation of miR-143, miR-145 and miR-223 in polycythemia vera mononuclear cells, up-regulation of miR-26b in polycythemia vera platelets, and down-regulation of miR-30b, miR-30c and miR-150 in polycythemia vera reticulocytes." -circulation_biomarker_diagnosis_up hsa-mir-182 Polycythemia Vera 18508790 "We observed down-regulation of let-7a and up-regulation of miR-182 in polycythemia vera granulocytes, up-regulation of miR-143, miR-145 and miR-223 in polycythemia vera mononuclear cells, up-regulation of miR-26b in polycythemia vera platelets, and down-regulation of miR-30b, miR-30c and miR-150 in polycythemia vera reticulocytes." -circulation_biomarker_diagnosis_up hsa-mir-223 Polycythemia Vera 18508790 "We observed down-regulation of let-7a and up-regulation of miR-182 in polycythemia vera granulocytes, up-regulation of miR-143, miR-145 and miR-223 in polycythemia vera mononuclear cells, up-regulation of miR-26b in polycythemia vera platelets, and down-regulation of miR-30b, miR-30c and miR-150 in polycythemia vera reticulocytes." -circulation_biomarker_diagnosis_up hsa-mir-26b Polycythemia Vera 18508790 "We observed down-regulation of let-7a and up-regulation of miR-182 in polycythemia vera granulocytes, up-regulation of miR-143, miR-145 and miR-223 in polycythemia vera mononuclear cells, up-regulation of miR-26b in polycythemia vera platelets, and down-regulation of miR-30b, miR-30c and miR-150 in polycythemia vera reticulocytes." -circulation_biomarker_diagnosis_up hsa-let-7a-1 "Lymphoma, Hodgkin" 18583325 "let-7a: overexpressed, down-regulation of PRDM1/Blimp-1" -circulation_biomarker_diagnosis_up hsa-let-7a-2 "Lymphoma, Hodgkin" 18583325 "let-7a: overexpressed, down-regulation of PRDM1/Blimp-1" -circulation_biomarker_diagnosis_up hsa-let-7a-3 "Lymphoma, Hodgkin" 18583325 "let-7a: overexpressed, down-regulation of PRDM1/Blimp-1" -circulation_biomarker_diagnosis_up hsa-mir-9-1 "Lymphoma, Hodgkin" 18583325 "miR-9: overexpressed, down-regulation of PRDM1/Blimp-1" -circulation_biomarker_diagnosis_up hsa-mir-9-2 "Lymphoma, Hodgkin" 18583325 "miR-9: overexpressed, down-regulation of PRDM1/Blimp-1" -circulation_biomarker_diagnosis_up hsa-mir-9-3 "Lymphoma, Hodgkin" 18583325 "miR-9: overexpressed, down-regulation of PRDM1/Blimp-1" -circulation_biomarker_diagnosis_up hsa-mir-17 "Carcinoma, Hepatocellular" 18688024 miR-17: Elevated expression of the miR-17-92 polycistron and miR-21 contributes to the malignant phenotype -circulation_biomarker_diagnosis_up hsa-mir-18a "Carcinoma, Hepatocellular" 18688024 miR-18a: Elevated expression of the miR-17-92 polycistron and miR-21 contributes to the malignant phenotype -circulation_biomarker_diagnosis_up hsa-mir-19a "Carcinoma, Hepatocellular" 18688024 miR-19a: Elevated expression of the miR-17-92 polycistron and miR-21 contributes to the malignant phenotype -circulation_biomarker_diagnosis_up hsa-mir-19b-1 "Carcinoma, Hepatocellular" 18688024 miR-19b: Elevated expression of the miR-17-92 polycistron and miR-21 contributes to the malignant phenotype -circulation_biomarker_diagnosis_up hsa-mir-19b-2 "Carcinoma, Hepatocellular" 18688024 miR-19b: Elevated expression of the miR-17-92 polycistron and miR-21 contributes to the malignant phenotype -circulation_biomarker_diagnosis_up hsa-mir-20a "Carcinoma, Hepatocellular" 18688024 miR-20a: Elevated expression of the miR-17-92 polycistron and miR-21 contributes to the malignant phenotype -circulation_biomarker_diagnosis_up hsa-mir-21 "Carcinoma, Hepatocellular" 18688024 miR-21: Elevated expression of the miR-17-92 polycistron and miR-21 contributes to the malignant phenotype -circulation_biomarker_diagnosis_up hsa-mir-92a-1 "Carcinoma, Hepatocellular" 18688024 miR-92a: Elevated expression of the miR-17-92 polycistron and miR-21 contributes to the malignant phenotype -circulation_biomarker_diagnosis_up hsa-mir-92a-2 "Carcinoma, Hepatocellular" 18688024 miR-92a: Elevated expression of the miR-17-92 polycistron and miR-21 contributes to the malignant phenotype -circulation_biomarker_diagnosis_up hsa-mir-377 Diabetic Nephropathy 18716028 miR-377: MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy -circulation_biomarker_diagnosis_up hsa-mir-20a Breast Neoplasms 18777135 miR-20a: increased expression in c-Myc induced mouse mammary tumors -circulation_biomarker_diagnosis_up hsa-mir-20b Breast Neoplasms 18777135 miR-20b: increased expression in c-Myc induced mouse mammary tumors -circulation_biomarker_diagnosis_up hsa-mir-9-1 Breast Neoplasms 18777135 miR-9: increased expression in c-Myc induced mouse mammary tumors -circulation_biomarker_diagnosis_up hsa-mir-9-2 Breast Neoplasms 18777135 miR-9: increased expression in c-Myc induced mouse mammary tumors -circulation_biomarker_diagnosis_up hsa-mir-9-3 Breast Neoplasms 18777135 miR-9: increased expression in c-Myc induced mouse mammary tumors -circulation_biomarker_diagnosis_up hsa-mir-206 Muscular Dystrophy 18827405 miR-206: miR-206 high expression for muscle regeneration and maturation -circulation_biomarker_diagnosis_up hsa-mir-1-1 Retinal Degeneration 18834879 miR-1: upregulation -circulation_biomarker_diagnosis_up hsa-mir-1-2 Retinal Degeneration 18834879 miR-1: upregulation -circulation_biomarker_diagnosis_up hsa-mir-133b Retinal Degeneration 18834879 miR-133: upregulation -circulation_biomarker_diagnosis_up hsa-mir-142 Retinal Degeneration 18834879 miR-142: upregulation -circulation_biomarker_diagnosis_up hsa-mir-196b Leukemia 18923441 the expression of miR-196b was 500-fold higher in MLL-rearranged and 800-fold higher in 5 of 15 T-ALL cases as compared with the expression level in the remaining precursor B-ALL cases (P<0.001). -circulation_biomarker_diagnosis_up hsa-let-7b Neurodegenerative Diseases [unspecific] 18987751 let-7b: up-regulated -circulation_biomarker_diagnosis_up hsa-mir-139 Neurodegenerative Diseases [unspecific] 18987751 miR-139-5p: up-regulated -circulation_biomarker_diagnosis_up hsa-mir-146a Neurodegenerative Diseases [unspecific] 18987751 miR-146a: up-regulated -circulation_biomarker_diagnosis_up hsa-mir-328 Neurodegenerative Diseases [unspecific] 18987751 miR-328: up-regulated -circulation_biomarker_diagnosis_up hsa-mir-342 Neurodegenerative Diseases [unspecific] 18987751 miR-342-3p: up-regulated -circulation_biomarker_diagnosis_up hsa-let-7a-1 Lupus Vulgaris 18998140 let-7a: upregulation -circulation_biomarker_diagnosis_up hsa-let-7a-2 Lupus Vulgaris 18998140 let-7a: upregulation -circulation_biomarker_diagnosis_up hsa-let-7a-3 Lupus Vulgaris 18998140 let-7a: upregulation -circulation_biomarker_diagnosis_up hsa-let-7e Lupus Vulgaris 18998140 let-7e: upregulation -circulation_biomarker_diagnosis_up hsa-mir-130b Lupus Vulgaris 18998140 miR-130b: upregulation -circulation_biomarker_diagnosis_up hsa-mir-134 Lupus Vulgaris 18998140 miR-134: upregulation -circulation_biomarker_diagnosis_up hsa-mir-142 Lupus Vulgaris 18998140 miR-142-5p: upregulation -circulation_biomarker_diagnosis_up hsa-mir-184 Lupus Vulgaris 18998140 miR-184: upregulation -circulation_biomarker_diagnosis_up hsa-mir-185 Lupus Vulgaris 18998140 miR-185: upregulation -circulation_biomarker_diagnosis_up hsa-mir-195 Lupus Vulgaris 18998140 miR-195: upregulation -circulation_biomarker_diagnosis_up hsa-mir-197 Lupus Vulgaris 18998140 miR-197: upregulation -circulation_biomarker_diagnosis_up hsa-mir-198 Lupus Vulgaris 18998140 miR-198: upregulation -circulation_biomarker_diagnosis_up hsa-mir-200c Lupus Vulgaris 18998140 miR-200c: upregulation -circulation_biomarker_diagnosis_up hsa-mir-208b Lupus Vulgaris 18998140 miR-208: upregulation -circulation_biomarker_diagnosis_up hsa-mir-23a Lupus Vulgaris 18998140 miR-23a: upregulation -circulation_biomarker_diagnosis_up hsa-mir-30a Lupus Vulgaris 18998140 miR-30a-5p: upregulation -circulation_biomarker_diagnosis_up hsa-mir-433 Lupus Vulgaris 18998140 miR-433: upregulation -circulation_biomarker_diagnosis_up hsa-mir-494 Lupus Vulgaris 18998140 miR-494: upregulation -circulation_biomarker_diagnosis_up hsa-mir-516a-1 Lupus Vulgaris 18998140 miR-516-5p: upregulation -circulation_biomarker_diagnosis_up hsa-mir-516a-2 Lupus Vulgaris 18998140 miR-516-5p: upregulation -circulation_biomarker_diagnosis_up hsa-mir-516b-1 Lupus Vulgaris 18998140 miR-516-5p: upregulation -circulation_biomarker_diagnosis_up hsa-mir-516b-2 Lupus Vulgaris 18998140 miR-516-5p: upregulation -circulation_biomarker_diagnosis_up hsa-mir-518c Lupus Vulgaris 18998140 miR-518c*: upregulation -circulation_biomarker_diagnosis_up hsa-mir-575 Lupus Vulgaris 18998140 miR-575: upregulation -circulation_biomarker_diagnosis_up hsa-mir-583 Lupus Vulgaris 18998140 miR-583: upregulation -circulation_biomarker_diagnosis_up hsa-mir-600 Lupus Vulgaris 18998140 miR-600: upregulation -circulation_biomarker_diagnosis_up hsa-mir-601 Lupus Vulgaris 18998140 miR-601: upregulation -circulation_biomarker_diagnosis_up hsa-mir-608 Lupus Vulgaris 18998140 miR-608: upregulation -circulation_biomarker_diagnosis_up hsa-mir-612 Lupus Vulgaris 18998140 miR-612: upregulation -circulation_biomarker_diagnosis_up hsa-mir-622 Lupus Vulgaris 18998140 miR-622: upregulation -circulation_biomarker_diagnosis_up hsa-mir-638 Lupus Vulgaris 18998140 miR-638: upregulation -circulation_biomarker_diagnosis_up hsa-mir-657 Lupus Vulgaris 18998140 miR-657: upregulation -circulation_biomarker_diagnosis_up hsa-mir-658 Lupus Vulgaris 18998140 miR-658: upregulation -circulation_biomarker_diagnosis_up hsa-mir-662 Lupus Vulgaris 18998140 miR-662: upregulation -circulation_biomarker_diagnosis_up hsa-mir-125a Leukemia 19022373 miR-125a: upregulated during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal -circulation_biomarker_diagnosis_up hsa-mir-339 Leukemia 19022373 miR-339: upregulated during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal -circulation_biomarker_diagnosis_up hsa-mir-660 Leukemia 19022373 miR-660: upregulated during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal -circulation_biomarker_diagnosis_up hsa-mir-663a Leukemia 19022373 miR-663: upregulated during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal -circulation_biomarker_diagnosis_up hsa-mir-145 Colorectal Carcinoma 19047896 miR-145: increased expression -circulation_biomarker_diagnosis_up hsa-mir-181b-1 Colorectal Carcinoma 19047896 miR-181b: increased expression -circulation_biomarker_diagnosis_up hsa-mir-203 Colorectal Carcinoma 19047896 miR-203: increased expression -circulation_biomarker_diagnosis_up hsa-mir-20a Colorectal Carcinoma 19047896 miR-20a: increased expression -circulation_biomarker_diagnosis_up hsa-mir-21 Colorectal Carcinoma 19047896 miR-21: increased expression -circulation_biomarker_diagnosis_up hsa-mir-372 "Carcinoma, Embryonal" 19057917 miR-372: highly up-regulated -circulation_biomarker_diagnosis_up hsa-mir-372 Cerebellum Cancer 19057917 miR-372: highly up-regulated -circulation_biomarker_diagnosis_up hsa-mir-373 "Carcinoma, Embryonal" 19057917 miR-373: highly up-regulated -circulation_biomarker_diagnosis_up hsa-mir-373 Cerebellum Cancer 19057917 miR-373: highly up-regulated -circulation_biomarker_diagnosis_up hsa-mir-17 "Leukemia, Myeloid" 19155294 miR-17: overexpressed -circulation_biomarker_diagnosis_up hsa-mir-18a "Leukemia, Myeloid" 19155294 miR-18a: overexpressed -circulation_biomarker_diagnosis_up hsa-mir-19a "Leukemia, Myeloid" 19155294 miR-19a: overexpressed -circulation_biomarker_diagnosis_up hsa-mir-19b-1 "Leukemia, Myeloid" 19155294 miR-19b: overexpressed -circulation_biomarker_diagnosis_up hsa-mir-19b-2 "Leukemia, Myeloid" 19155294 miR-19b: overexpressed -circulation_biomarker_diagnosis_up hsa-mir-20a "Leukemia, Myeloid" 19155294 miR-20a: overexpressed -circulation_biomarker_diagnosis_up hsa-mir-92a-1 "Leukemia, Myeloid" 19155294 miR-92a: overexpressed -circulation_biomarker_diagnosis_up hsa-mir-92a-2 "Leukemia, Myeloid" 19155294 miR-92a: overexpressed -circulation_biomarker_diagnosis_up hsa-mir-155 "Lymphoma, Hodgkin" 19177201 miR-155: overexpressed -circulation_biomarker_diagnosis_up hsa-mir-16-1 "Lymphoma, Hodgkin" 19177201 miR-16: overexpressed -circulation_biomarker_diagnosis_up hsa-mir-16-2 "Lymphoma, Hodgkin" 19177201 miR-16: overexpressed -circulation_biomarker_diagnosis_up hsa-mir-17 "Lymphoma, Hodgkin" 19177201 miR-17: overexpressed -circulation_biomarker_diagnosis_up hsa-mir-18a "Lymphoma, Hodgkin" 19177201 miR-18a: overexpressed -circulation_biomarker_diagnosis_up hsa-mir-19a "Lymphoma, Hodgkin" 19177201 miR-19a: overexpressed -circulation_biomarker_diagnosis_up hsa-mir-19b-1 "Lymphoma, Hodgkin" 19177201 miR-19b: overexpressed -circulation_biomarker_diagnosis_up hsa-mir-19b-2 "Lymphoma, Hodgkin" 19177201 miR-19b: overexpressed -circulation_biomarker_diagnosis_up hsa-mir-20a "Lymphoma, Hodgkin" 19177201 miR-20a: overexpressed -circulation_biomarker_diagnosis_up hsa-mir-21 "Lymphoma, Hodgkin" 19177201 miR-21: overexpressed -circulation_biomarker_diagnosis_up hsa-mir-24-1 "Lymphoma, Hodgkin" 19177201 miR-24: overexpressed -circulation_biomarker_diagnosis_up hsa-mir-24-2 "Lymphoma, Hodgkin" 19177201 miR-24: overexpressed -circulation_biomarker_diagnosis_up hsa-mir-92a-1 "Lymphoma, Hodgkin" 19177201 miR-92a: overexpressed -circulation_biomarker_diagnosis_up hsa-mir-92a-2 "Lymphoma, Hodgkin" 19177201 miR-92a: overexpressed -circulation_biomarker_diagnosis_up hsa-mir-142 "Leukemia-Lymphoma, Precursor B-Cell Lymphoblastic" 19206004 miR-142-3p: up-regulated -circulation_biomarker_diagnosis_up hsa-mir-222 "Leukemia-Lymphoma, Precursor B-Cell Lymphoblastic" 19206004 miR-222: up-regulated -circulation_biomarker_diagnosis_up hsa-mir-339 "Leukemia-Lymphoma, Precursor B-Cell Lymphoblastic" 19206004 miR-339: up-regulated -circulation_biomarker_diagnosis_up hsa-mir-184 Tongue Neoplasms 19219377 miR-184: overexpressed -circulation_biomarker_diagnosis_up hsa-mir-31 Colorectal Carcinoma 19242066 miR-31: up-regulated compared with normal control -circulation_biomarker_diagnosis_up hsa-mir-1-1 Myocardial Infarction 19245789 miR-1: Upregulated expression in a rat model -circulation_biomarker_diagnosis_up hsa-mir-1-2 Myocardial Infarction 19245789 miR-1: Upregulated expression in a rat model -circulation_biomarker_diagnosis_up hsa-mir-206 Myocardial Infarction 19245789 miR-206: Upregulated expression in a rat model -circulation_biomarker_diagnosis_up hsa-mir-132 Autistic Disorder 19360674 miR-132: upregulated -circulation_biomarker_diagnosis_up hsa-mir-146a Autistic Disorder 19360674 miR-146a: upregulated -circulation_biomarker_diagnosis_up hsa-mir-146b Autistic Disorder 19360674 mir-146b: upregulated -circulation_biomarker_diagnosis_up hsa-mir-23a Autistic Disorder 19360674 miR-23a: upregulated -circulation_biomarker_diagnosis_up hsa-mir-23b Autistic Disorder 19360674 miR-23b: upregulated -circulation_biomarker_diagnosis_up hsa-mir-663a Autistic Disorder 19360674 miR-663: upregulated -circulation_biomarker_diagnosis_up hsa-mir-342 Prion Diseases 19712440 upregulated -circulation_biomarker_diagnosis_up hsa-mir-494 Prion Diseases 19712440 upregulated -circulation_biomarker_diagnosis_up hsa-mir-181a-2 "Leukemia, Lymphocytic, Chronic, B-Cell" 19717645 high expression -circulation_biomarker_diagnosis_up hsa-mir-15a Schizophrenia 19721432 upregulated -circulation_biomarker_diagnosis_up hsa-mir-15b Schizophrenia 19721432 upregulated -circulation_biomarker_diagnosis_up hsa-mir-196a-1 Pancreatic Adenocarcinoma 19723895 uperegulated -circulation_biomarker_diagnosis_up hsa-mir-196a-2 Pancreatic Adenocarcinoma 19723895 uperegulated -circulation_biomarker_diagnosis_up hsa-mir-122 Stroke 19745058 diagnostical sensitivity: illustrated liver and muscle toxicity -circulation_biomarker_diagnosis_up hsa-mir-124-1 Stroke 19745058 "diagnostical sensitivity:illustrated injuries in liver, muscle, and brain" -circulation_biomarker_diagnosis_up hsa-mir-124-2 Stroke 19745058 "diagnostical sensitivity:illustrated injuries in liver, muscle, and brain" -circulation_biomarker_diagnosis_up hsa-mir-124-3 Stroke 19745058 "diagnostical sensitivity:illustrated injuries in liver, muscle, and brain" -circulation_biomarker_diagnosis_up hsa-mir-133a-1 Stroke 19745058 diagnostical sensitivity: illustrated liver and muscle toxicity -circulation_biomarker_diagnosis_up hsa-mir-133a-2 Stroke 19745058 diagnostical sensitivity: illustrated liver and muscle toxicity -circulation_biomarker_diagnosis_up hsa-mir-208a Myocardial Infarction 20159880 Elevated cardiac-specific miR-208a in plasma may be a novel biomarker for early detection of myocardial injury in humans -circulation_biomarker_diagnosis_up hsa-mir-423 Heart Failure 20185794 MiR423-5p as a circulating biomarker for heart failure -circulation_biomarker_diagnosis_up hsa-mir-210 "Squamous Cell Carcinoma, Head and Neck" 20187102 Expression of hsa-miR-210 in head and neck cancer correlates with other approaches for assessing hypoxia and is associated with prognosis -circulation_biomarker_diagnosis_up hsa-mir-106a Neoplasms [unspecific] 20234369 "the plasma concentrations of miRNAs (miR-17-5p, miR-21, miR-106a, miR-106b) were significantly higher in GC patients than controls" -circulation_biomarker_diagnosis_up hsa-mir-17 Neoplasms [unspecific] 20234369 "the plasma concentrations of miRNAs (miR-17-5p, miR-21, miR-106a, miR-106b) were significantly higher in GC patients than controls" -circulation_biomarker_diagnosis_up hsa-mir-21 Neoplasms [unspecific] 20234369 "the plasma concentrations of miRNAs (miR-17-5p, miR-21, miR-106a, miR-106b) were significantly higher in GC patients than controls" -circulation_biomarker_diagnosis_up hsa-mir-210 Pancreatic Neoplasms 20360935 Circulating miR-210 as a Novel Hypoxia Marker in Pancreatic Cancer -circulation_biomarker_diagnosis_up hsa-mir-23a "Child Development Disorders, Pervasive" 20374639 up-regulation -circulation_biomarker_diagnosis_up hsa-mir-21 "Leukemia, Lymphocytic, Chronic, B-Cell" 20393129 microRNA fingerprinting of CLL patients with chromosome 17p deletion identify a miR-21 score that stratifies early survival -circulation_biomarker_diagnosis_up hsa-mir-499a Myocardial Infarction 20395621 Plasma microRNA 499 as a biomarker of acute myocardial infarction -circulation_biomarker_diagnosis_up hsa-mir-223 "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 20418243 miR-223:over-expression of miR-223 -circulation_biomarker_diagnosis_up hsa-mir-126 Atherosclerosis 20489169 miR-126:found high levels of expression for all of them in quiescent endothelial cells -circulation_biomarker_diagnosis_up hsa-mir-17 Atherosclerosis 20489169 miR-17-5p:found high levels of expression for all of them in quiescent endothelial cells -circulation_biomarker_diagnosis_up hsa-mir-21 Atherosclerosis 20489169 miR-21:found high levels of expression for all of them in quiescent endothelial cells -circulation_biomarker_diagnosis_up hsa-mir-210 Atherosclerosis 20489169 miR-210:found high levels of expression for all of them in quiescent endothelial cells -circulation_biomarker_diagnosis_up hsa-mir-221 Atherosclerosis 20489169 miR-221:found high levels of expression for all of them in quiescent endothelial cells -circulation_biomarker_diagnosis_up hsa-mir-222 Atherosclerosis 20489169 miR-222:found high levels of expression for all of them in quiescent endothelial cells -circulation_biomarker_diagnosis_up hsa-mir-296 Atherosclerosis 20489169 miR-296:found high levels of expression for all of them in quiescent endothelial cells -circulation_biomarker_diagnosis_up hsa-mir-148a "Leukemia, Lymphocytic, Chronic, B-Cell" 20504344 "miR-148a:miR-148a, miR-222 and miR-21 exhibited a significantly higher expression in non-responder patients" -circulation_biomarker_diagnosis_up hsa-mir-21 "Leukemia, Lymphocytic, Chronic, B-Cell" 20504344 "miR-21:miR-148a, miR-222 and miR-21 exhibited a significantly higher expression in non-responder patients" -circulation_biomarker_diagnosis_up hsa-mir-222 "Leukemia, Lymphocytic, Chronic, B-Cell" 20504344 "miR-222:miR-148a, miR-222 and miR-21 exhibited a significantly higher expression in non-responder patients" -circulation_biomarker_diagnosis_up hsa-let-7d Melanoma 20529253 let-7d:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-1249 Melanoma 20529253 miR-1249:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-125a Melanoma 20529253 miR-125a-5p:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-1280 Melanoma 20529253 miR-1280:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-142 Melanoma 20529253 miR-142-3p:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-145 Melanoma 20529253 miR-145:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-146a Melanoma 20529253 miR-146a:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-151a Melanoma 20529253 miR-151-3p:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-181a-2 Melanoma 20529253 miR-181a-2*:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-183 Melanoma 20529253 miR-183*:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-186 Melanoma 20529253 miR-186:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-18a Melanoma 20529253 miR-18a:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-199a-1 Melanoma 20529253 miR-199a-5p:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-199a-2 Melanoma 20529253 miR-199a-5p:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-22 Melanoma 20529253 miR-22*:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-30a Melanoma 20529253 miR-30a:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-30e Melanoma 20529253 miR-30e*:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-328 Melanoma 20529253 miR-328:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-342 Melanoma 20529253 miR-342-5p:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-361 Melanoma 20529253 miR-361-3p:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-362 Melanoma 20529253 miR-362-3p:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-365a Melanoma 20529253 miR-365:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-365b Melanoma 20529253 miR-365:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-378a Melanoma 20529253 miR-378*:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-422a Melanoma 20529253 miR-422a:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-501 Melanoma 20529253 miR-501-5p:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-550a-1 Melanoma 20529253 miR-550*:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-550a-2 Melanoma 20529253 miR-550*:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-584 Melanoma 20529253 miR-584:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-625 Melanoma 20529253 miR-625:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-664 Melanoma 20529253 miR-664:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-99a Melanoma 20529253 miR-99a:21 miRNAs that were downregulated in blood cells of melanoma patients and 30 miRNAs that were upregulated in blood cells of melanoma patients -circulation_biomarker_diagnosis_up hsa-mir-125b-1 "Leukemia, Myeloid" 20660734 "miR-125b:Overexpression of the most advantageous miRNA, miR-125b, caused a dose-dependent myeloproliferative disorder that progressed to a lethal myeloid leukemia in mice" -circulation_biomarker_diagnosis_up hsa-mir-125b-2 "Leukemia, Myeloid" 20660734 "miR-125b:Overexpression of the most advantageous miRNA, miR-125b, caused a dose-dependent myeloproliferative disorder that progressed to a lethal myeloid leukemia in mice" -circulation_biomarker_diagnosis_up hsa-mir-206 Rhabdomyosarcoma 20696132 "miR-206:miR-206, as landmark biomarkers for RMS" -circulation_biomarker_diagnosis_up hsa-mir-155 "Lymphoma, Large-Cell, Anaplastic" 20805506 "miR-155:Five members of the miR-17-92 cluster were expressed more highly in ALK(+) ALCL, whereas miR-155 was expressed more than 10-fold higher in ALK(-) ALCL" -circulation_biomarker_diagnosis_up hsa-mir-17 "Lymphoma, Large-Cell, Anaplastic" 20805506 "miR-17:Five members of the miR-17-92 cluster were expressed more highly in ALK(+) ALCL, whereas miR-155 was expressed more than 10-fold higher in ALK(-) ALCL" -circulation_biomarker_diagnosis_up hsa-mir-18a "Lymphoma, Large-Cell, Anaplastic" 20805506 "miR-18a:Five members of the miR-17-92 cluster were expressed more highly in ALK(+) ALCL, whereas miR-155 was expressed more than 10-fold higher in ALK(-) ALCL" -circulation_biomarker_diagnosis_up hsa-mir-19a "Lymphoma, Large-Cell, Anaplastic" 20805506 "miR-19a:Five members of the miR-17-92 cluster were expressed more highly in ALK(+) ALCL, whereas miR-155 was expressed more than 10-fold higher in ALK(-) ALCL" -circulation_biomarker_diagnosis_up hsa-mir-19b-1 "Lymphoma, Large-Cell, Anaplastic" 20805506 "miR-19b:Five members of the miR-17-92 cluster were expressed more highly in ALK(+) ALCL, whereas miR-155 was expressed more than 10-fold higher in ALK(-) ALCL" -circulation_biomarker_diagnosis_up hsa-mir-19b-2 "Lymphoma, Large-Cell, Anaplastic" 20805506 "miR-19b:Five members of the miR-17-92 cluster were expressed more highly in ALK(+) ALCL, whereas miR-155 was expressed more than 10-fold higher in ALK(-) ALCL" -circulation_biomarker_diagnosis_up hsa-mir-20a "Lymphoma, Large-Cell, Anaplastic" 20805506 "miR-20a:Five members of the miR-17-92 cluster were expressed more highly in ALK(+) ALCL, whereas miR-155 was expressed more than 10-fold higher in ALK(-) ALCL" -circulation_biomarker_diagnosis_up hsa-mir-92a-1 "Lymphoma, Large-Cell, Anaplastic" 20805506 "miR-92a:Five members of the miR-17-92 cluster were expressed more highly in ALK(+) ALCL, whereas miR-155 was expressed more than 10-fold higher in ALK(-) ALCL" -circulation_biomarker_diagnosis_up hsa-mir-92a-2 "Lymphoma, Large-Cell, Anaplastic" 20805506 "miR-92a:Five members of the miR-17-92 cluster were expressed more highly in ALK(+) ALCL, whereas miR-155 was expressed more than 10-fold higher in ALK(-) ALCL" -circulation_biomarker_diagnosis_up hsa-mir-208b Myocardial Infarction 20921333 miRs-208b and -499 were highly elevated in acute myocardial infarction plasma -circulation_biomarker_diagnosis_up hsa-mir-208b Viral Myocarditis 20921333 a milder but significant elevation of miRs-208b and -499 were highly elevated in Viral Myocarditis plasma -circulation_biomarker_diagnosis_up hsa-mir-499a Heart Failure 20921333 miR-499 was significantly elevated -circulation_biomarker_diagnosis_up hsa-mir-499a Myocardial Infarction 20921333 miRs-208b and -499 were highly elevated in acute myocardial infarction plasma -circulation_biomarker_diagnosis_up hsa-mir-499a Viral Myocarditis 20921333 a milder but significant elevation of miRs-208b and -499 were highly elevated in Viral Myocarditis plasma -circulation_biomarker_diagnosis_up hsa-let-7e Synovial Sarcoma 21140508 upregulated -circulation_biomarker_diagnosis_up hsa-mir-125a Synovial Sarcoma 21140508 miR-125a-3p: upregulated -circulation_biomarker_diagnosis_up hsa-mir-99b Synovial Sarcoma 21140508 upregulated -circulation_biomarker_diagnosis_up hsa-mir-326 Multiple Sclerosis 21151203 The expression of miRNA-326 in blood cells has been reported to increase during relapses. -circulation_biomarker_diagnosis_up hsa-mir-122 Liver Neoplasms 21154767 "in serum, miR-21, miR-122, and miR-223 were significantly higher in patients with HCC than those in healthy controls" -circulation_biomarker_diagnosis_up hsa-mir-223 Liver Neoplasms 21154767 "in serum, miR-21, miR-122, and miR-223 were significantly higher in patients with HCC than those in healthy controls" -circulation_biomarker_diagnosis_up hsa-mir-183 Urinary Bladder Cancer 21166959 "MiR-96 and miR-183 detection in urine serve as potential tumor markers of urothelial carcinoma: correlation with stage and grade, and comparison with urinary cytology." -circulation_biomarker_diagnosis_up hsa-mir-96 Urinary Bladder Cancer 21166959 "MiR-96 and miR-183 detection in urine serve as potential tumor markers of urothelial carcinoma: correlation with stage and grade, and comparison with urinary cytology." -circulation_biomarker_diagnosis_up hsa-mir-122 "Carcinoma, Hepatocellular" 21229610 "Our results indicate that serum miR-21, miR-122 and miR-223 are elevated in patients with HCC or chronic hepatitis and these miRNAs have strong potential to serve as novel biomarkers for liver injury but not specifically for HCC." -circulation_biomarker_diagnosis_up hsa-mir-21 "Carcinoma, Hepatocellular" 21229610 "Our results indicate that serum miR-21, miR-122 and miR-223 are elevated in patients with HCC or chronic hepatitis and these miRNAs have strong potential to serve as novel biomarkers for liver injury but not specifically for HCC." -circulation_biomarker_diagnosis_up hsa-mir-223 "Carcinoma, Hepatocellular" 21229610 "Our results indicate that serum miR-21, miR-122 and miR-223 are elevated in patients with HCC or chronic hepatitis and these miRNAs have strong potential to serve as novel biomarkers for liver injury but not specifically for HCC." -circulation_biomarker_diagnosis_up hsa-mir-100 "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 21242186 "aberrant downregulation of let-7b (~70-fold) in MLL-rearranged acute lymphoblastic leukemia was linked to upregulation of oncoprotein c-Myc (P<0.0001). Resistance to vincristine and daunorubicin was characterized by ~20-fold upregulation of miR-125b, miR-99a and miR-100 (P<0.002)." -circulation_biomarker_diagnosis_up hsa-mir-125b-1 "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 21242186 "aberrant downregulation of let-7b (~70-fold) in MLL-rearranged acute lymphoblastic leukemia was linked to upregulation of oncoprotein c-Myc (P<0.0001). Resistance to vincristine and daunorubicin was characterized by ~20-fold upregulation of miR-125b, miR-99a and miR-100 (P<0.002)." -circulation_biomarker_diagnosis_up hsa-mir-125b-2 "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 21242186 "aberrant downregulation of let-7b (~70-fold) in MLL-rearranged acute lymphoblastic leukemia was linked to upregulation of oncoprotein c-Myc (P<0.0001). Resistance to vincristine and daunorubicin was characterized by ~20-fold upregulation of miR-125b, miR-99a and miR-100 (P<0.002)." -circulation_biomarker_diagnosis_up hsa-mir-99a "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 21242186 "aberrant downregulation of let-7b (~70-fold) in MLL-rearranged acute lymphoblastic leukemia was linked to upregulation of oncoprotein c-Myc (P<0.0001). Resistance to vincristine and daunorubicin was characterized by ~20-fold upregulation of miR-125b, miR-99a and miR-100 (P<0.002)." -circulation_biomarker_diagnosis_up hsa-mir-181a-1 "Squamous Cell Carcinoma, Oral" 21244495 "miR-181 as a putative biomarker for lymph-node metastasis of oral squamous cell carcinoma.miR-181 may enhance lymph-node metastasis through regulating migration, which could potentially be exploited as a putative biomarker for patients with OSCC." -circulation_biomarker_diagnosis_up hsa-mir-181a-2 "Squamous Cell Carcinoma, Oral" 21244495 "miR-181 as a putative biomarker for lymph-node metastasis of oral squamous cell carcinoma.miR-181 may enhance lymph-node metastasis through regulating migration, which could potentially be exploited as a putative biomarker for patients with OSCC." -circulation_biomarker_diagnosis_up hsa-mir-181b-1 "Squamous Cell Carcinoma, Oral" 21244495 "miR-181 as a putative biomarker for lymph-node metastasis of oral squamous cell carcinoma.miR-181 may enhance lymph-node metastasis through regulating migration, which could potentially be exploited as a putative biomarker for patients with OSCC." -circulation_biomarker_diagnosis_up hsa-mir-181b-2 "Squamous Cell Carcinoma, Oral" 21244495 "miR-181 as a putative biomarker for lymph-node metastasis of oral squamous cell carcinoma.miR-181 may enhance lymph-node metastasis through regulating migration, which could potentially be exploited as a putative biomarker for patients with OSCC." -circulation_biomarker_diagnosis_up hsa-mir-181c "Squamous Cell Carcinoma, Oral" 21244495 "miR-181 as a putative biomarker for lymph-node metastasis of oral squamous cell carcinoma.miR-181 may enhance lymph-node metastasis through regulating migration, which could potentially be exploited as a putative biomarker for patients with OSCC." -circulation_biomarker_diagnosis_up hsa-mir-181d "Squamous Cell Carcinoma, Oral" 21244495 "miR-181 as a putative biomarker for lymph-node metastasis of oral squamous cell carcinoma.miR-181 may enhance lymph-node metastasis through regulating migration, which could potentially be exploited as a putative biomarker for patients with OSCC." -circulation_biomarker_diagnosis_up hsa-mir-1254-1 "Carcinoma, Lung, Non-Small-Cell" 21258252 miR-1254 and miR-574-5p: Serum-Based microRNA Biomarkers for Early-Stage Non-small Cell Lung Cancer. The expression of hsa-miR-1254 and hsa-miR-574-5p was significantly increased in the early-stage NSCLC samples with respect to the controls. The utility of miR-1254 and miR-574-5p serum-based biomarkers as minimally invasive screening and triage tools for subsequent diagnostic evaluation warrants additional validation. -circulation_biomarker_diagnosis_up hsa-mir-574 "Carcinoma, Lung, Non-Small-Cell" 21258252 miR-1254 and miR-574-5p: Serum-Based microRNA Biomarkers for Early-Stage Non-small Cell Lung Cancer. The expression of hsa-miR-1254 and hsa-miR-574-5p was significantly increased in the early-stage NSCLC samples with respect to the controls. The utility of miR-1254 and miR-574-5p serum-based biomarkers as minimally invasive screening and triage tools for subsequent diagnostic evaluation warrants additional validation. -circulation_biomarker_diagnosis_up hsa-mir-221 Melanoma 21273047 Malignant melanoma patients had significantly higher miR-221 levels than healthy controls in serum. -circulation_biomarker_diagnosis_up hsa-mir-141 Prostate Neoplasms 21274675 the miRNA levels in patient blood were higher than that of the controls -circulation_biomarker_diagnosis_up hsa-mir-21 Prostate Neoplasms 21274675 the miRNA levels in patient blood were higher than that of the controls -circulation_biomarker_diagnosis_up hsa-mir-221 Prostate Neoplasms 21274675 the miRNA levels in patient blood were higher than that of the controls -circulation_biomarker_diagnosis_up hsa-mir-21 Hypertrophy 21303526 "The downregulation of miR-1, miR-133a, and upregulation of miR-21 can be reversed by one single upstream regulator, SRF." -circulation_biomarker_diagnosis_up hsa-mir-148a Medulloblastoma 21358093 "A number of miRNAs like miR-193a, miR-224/miR-452 cluster, miR-182/miR-183/miR-96 cluster, and miR-148a having potential tumor/metastasis suppressive activity were found to be overexpressed in the WNT signaling associated medulloblastomas." -circulation_biomarker_diagnosis_up hsa-mir-182 Medulloblastoma 21358093 "A number of miRNAs like miR-193a, miR-224/miR-452 cluster, miR-182/miR-183/miR-96 cluster, and miR-148a having potential tumor/metastasis suppressive activity were found to be overexpressed in the WNT signaling associated medulloblastomas." -circulation_biomarker_diagnosis_up hsa-mir-183 Medulloblastoma 21358093 "A number of miRNAs like miR-193a, miR-224/miR-452 cluster, miR-182/miR-183/miR-96 cluster, and miR-148a having potential tumor/metastasis suppressive activity were found to be overexpressed in the WNT signaling associated medulloblastomas." -circulation_biomarker_diagnosis_up hsa-mir-193a Medulloblastoma 21358093 "A number of miRNAs like miR-193a, miR-224/miR-452 cluster, miR-182/miR-183/miR-96 cluster, and miR-148a having potential tumor/metastasis suppressive activity were found to be overexpressed in the WNT signaling associated medulloblastomas." -circulation_biomarker_diagnosis_up hsa-mir-193b Medulloblastoma 21358093 "A number of miRNAs like miR-193a, miR-224/miR-452 cluster, miR-182/miR-183/miR-96 cluster, and miR-148a having potential tumor/metastasis suppressive activity were found to be overexpressed in the WNT signaling associated medulloblastomas." -circulation_biomarker_diagnosis_up hsa-mir-224 Medulloblastoma 21358093 "A number of miRNAs like miR-193a, miR-224/miR-452 cluster, miR-182/miR-183/miR-96 cluster, and miR-148a having potential tumor/metastasis suppressive activity were found to be overexpressed in the WNT signaling associated medulloblastomas." -circulation_biomarker_diagnosis_up hsa-mir-452 Medulloblastoma 21358093 "A number of miRNAs like miR-193a, miR-224/miR-452 cluster, miR-182/miR-183/miR-96 cluster, and miR-148a having potential tumor/metastasis suppressive activity were found to be overexpressed in the WNT signaling associated medulloblastomas." -circulation_biomarker_diagnosis_up hsa-mir-96 Medulloblastoma 21358093 "A number of miRNAs like miR-193a, miR-224/miR-452 cluster, miR-182/miR-183/miR-96 cluster, and miR-148a having potential tumor/metastasis suppressive activity were found to be overexpressed in the WNT signaling associated medulloblastomas." -circulation_biomarker_diagnosis_up hsa-mir-210 Ischemic Diseases [unspecific] 21360638 "High levels of miR-210 have been linked to an in vivo hypoxic signature and associated with adverse prognosis in cancer patients. A wide spectrum of miR-210 targets have been identified, with roles in mitochondrial metabolism, angiogenesis, DNA repair, and cell survival." -circulation_biomarker_diagnosis_up hsa-mir-155 "Leukemia, Lymphocytic, Chronic, B-Cell" 21408091 upregulation -circulation_biomarker_diagnosis_up hsa-mir-342 "Leukemia, Lymphocytic, Chronic, B-Cell" 21408091 miR-342-3p upregulation -circulation_biomarker_diagnosis_up hsa-mir-34a "Leukemia, Lymphocytic, Chronic, B-Cell" 21408091 upregulation -circulation_biomarker_diagnosis_up hsa-mir-34b Huntington Disease 21421997 Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington's disease. -circulation_biomarker_diagnosis_up hsa-mir-1-1 "Muscular Dystrophy, Duchenne" 21479190 "the serum levels of several muscle-specific miRNAs (miR-1, miR-133a and miR-206) are increased" -circulation_biomarker_diagnosis_up hsa-mir-1-2 "Muscular Dystrophy, Duchenne" 21479190 "the serum levels of several muscle-specific miRNAs (miR-1, miR-133a and miR-206) are increased" -circulation_biomarker_diagnosis_up hsa-mir-133a-1 "Muscular Dystrophy, Duchenne" 21479190 "the serum levels of several muscle-specific miRNAs (miR-1, miR-133a and miR-206) are increased" -circulation_biomarker_diagnosis_up hsa-mir-133a-2 "Muscular Dystrophy, Duchenne" 21479190 "the serum levels of several muscle-specific miRNAs (miR-1, miR-133a and miR-206) are increased" -circulation_biomarker_diagnosis_up hsa-mir-206 "Muscular Dystrophy, Duchenne" 21479190 "the serum levels of several muscle-specific miRNAs (miR-1, miR-133a and miR-206) are increased" -circulation_biomarker_diagnosis_up hsa-mir-146a Systemic Lupus Erythematosus 21529448 Increased Expression in Peripheral Blood Mononuclear Cells in Patients with Systemic Lupus Erythematosus. -circulation_biomarker_diagnosis_up hsa-mir-9-1 Wounds and Injuries [unspecific] 21538484 Upregulated in in serum -circulation_biomarker_diagnosis_up hsa-mir-9-2 Wounds and Injuries [unspecific] 21538484 Upregulated in in serum -circulation_biomarker_diagnosis_up hsa-mir-9-3 Wounds and Injuries [unspecific] 21538484 Upregulated in in serum -circulation_biomarker_diagnosis_up hsa-mir-29c "Carcinoma, Lung, Non-Small-Cell" 21544802 "The expression of miR-146b, miR-221, let-7a, miR-155, miR-17-5p, miR-27a and miR-106a were significantly reduced in the serum of NSCLC cases while miR-29c was significantly increased." -circulation_biomarker_diagnosis_up hsa-mir-124-1 Acute Cerebral Infarction 21551949 "Plasma concentrations of miR-124 were significantly elevated at 6 h, and remained elevated at 48 h after middle cerebral artery occlusion introduction." -circulation_biomarker_diagnosis_up hsa-mir-124-2 Acute Cerebral Infarction 21551949 "Plasma concentrations of miR-124 were significantly elevated at 6 h, and remained elevated at 48 h after middle cerebral artery occlusion introduction." -circulation_biomarker_diagnosis_up hsa-mir-124-3 Acute Cerebral Infarction 21551949 "Plasma concentrations of miR-124 were significantly elevated at 6 h, and remained elevated at 48 h after middle cerebral artery occlusion introduction." -circulation_biomarker_diagnosis_up hsa-mir-128-1 Glioblastoma 21561454 upregulated in the peripheral blood of glioblastoma patients. -circulation_biomarker_diagnosis_up hsa-mir-128-2 Glioblastoma 21561454 upregulated in the peripheral blood of glioblastoma patients. -circulation_biomarker_diagnosis_up hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 21627863 "Plasma miR-21 was significantly higher in NSCLC patients than in age- and sex-matched controls (P < 0.001). miR-21 was related to TNM stage (P < 0.001), but not related to age, sex, smoking status, histological classification, lymph node status, and metastasis (all P > 0.05)." -circulation_biomarker_diagnosis_up hsa-mir-1-1 Myocardial Infarction 21642241 Increased MicroRNA-1 and MicroRNA-133a Levels in Serum of Patients With Cardiovascular Disease Indicate Myocardial Damage. -circulation_biomarker_diagnosis_up hsa-mir-1-2 Myocardial Infarction 21642241 Increased MicroRNA-1 and MicroRNA-133a Levels in Serum of Patients With Cardiovascular Disease Indicate Myocardial Damage. -circulation_biomarker_diagnosis_up hsa-mir-133a-1 Myocardial Infarction 21642241 Increased MicroRNA-1 and MicroRNA-133a Levels in Serum of Patients With Cardiovascular Disease Indicate Myocardial Damage. -circulation_biomarker_diagnosis_up hsa-mir-133a-2 Myocardial Infarction 21642241 Increased MicroRNA-1 and MicroRNA-133a Levels in Serum of Patients With Cardiovascular Disease Indicate Myocardial Damage. -circulation_biomarker_diagnosis_up hsa-mir-21 Myelodysplastic Syndromes 21649547 up-regulation -circulation_biomarker_diagnosis_up hsa-mir-720 Myelodysplastic Syndromes 21649547 up-regulation -circulation_biomarker_diagnosis_up hsa-mir-21 "Squamous Cell Carcinoma, Esophageal" 21673684 "the plasma level of miR-21 was significantly higher (P=0.0218) and that of miR-375 (P=0.0052) was significantly lower in ESCC patients than controls. (2) The high plasma miR-21 levels reflected tumour levels in all cases (100%). The plasma level of miR-21 was significantly reduced in postoperative samples (P=0.0058). (3) On validation analysis, the plasma level of miR-21 tended to be higher in ESCC patients (P=0.0649), while that of miR-375 was significantly lower (P<0.0001) and the miR-21/miR-375 ratio was significantly higher (P<0.0001) in ESCC patients than in controls. The value of the area under the receiver-operating characteristic curve (AUC) was 0.816 for the miR-21/miR-375 ratio assay. Patients with a high plasma level of miR-21 tended to have greater vascular invasion (P=0.1554) and to show a high correlation with recurrence (P=0.0164)." -circulation_biomarker_diagnosis_up hsa-mir-146a Glomerulonephritis 21694443 The expression levels of miR-146a and miR-155 in kidney biopsy and urine from patients with IgA nephropathy were elevated. -circulation_biomarker_diagnosis_up hsa-mir-155 Glomerulonephritis 21694443 The expression levels of miR-146a and miR-155 in kidney biopsy and urine from patients with IgA nephropathy were elevated. -circulation_biomarker_diagnosis_up hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 21721011 serum miR-21 expression was an independent prognostic factor for NSCLC patients. -circulation_biomarker_diagnosis_up hsa-mir-10a "Leukemia, Myeloid, Acute" 21784052 miR-10a overexpression is associated with NPM1 mutations and MDM4 downregulation in intermediate-risk acute myeloid leukemia. -circulation_biomarker_diagnosis_up hsa-mir-196a-1 "Leukemia, Myeloid, Acute" 21818844 "High miR-196a and -b expression was observed in patients carrying MLL gene rearrangements, NPM1 mutations, or FLT3-ITD in a cytogenetically normal background, compared to all other patients. In contrast, CEBPA mutated cases had a low expression of miR-196a and -b. Expression of miR-196a and -b was correlated with expression of neighboring HOXA and HOXB genes." -circulation_biomarker_diagnosis_up hsa-mir-196a-2 "Leukemia, Myeloid, Acute" 21818844 "High miR-196a and -b expression was observed in patients carrying MLL gene rearrangements, NPM1 mutations, or FLT3-ITD in a cytogenetically normal background, compared to all other patients. In contrast, CEBPA mutated cases had a low expression of miR-196a and -b. Expression of miR-196a and -b was correlated with expression of neighboring HOXA and HOXB genes." -circulation_biomarker_diagnosis_up hsa-mir-196b "Leukemia, Myeloid, Acute" 21818844 "High miR-196a and -b expression was observed in patients carrying MLL gene rearrangements, NPM1 mutations, or FLT3-ITD in a cytogenetically normal background, compared to all other patients. In contrast, CEBPA mutated cases had a low expression of miR-196a and -b. Expression of miR-196a and -b was correlated with expression of neighboring HOXA and HOXB genes." -circulation_biomarker_diagnosis_up hsa-mir-146a Atherosclerosis 21820659 "miR-21, miR-210, miR-34a, and miR-146a/b are up-regulated in human atherosclerotic plaques (compared to non-atherosclerotic left internal thoracic arteries (LITA)) in the Tampere Vascular Study." -circulation_biomarker_diagnosis_up hsa-mir-146b Atherosclerosis 21820659 "miR-21, miR-210, miR-34a, and miR-146a/b are up-regulated in human atherosclerotic plaques (compared to non-atherosclerotic left internal thoracic arteries (LITA)) in the Tampere Vascular Study." -circulation_biomarker_diagnosis_up hsa-mir-21 Atherosclerosis 21820659 "miR-21, miR-210, miR-34a, and miR-146a/b are up-regulated in human atherosclerotic plaques (compared to non-atherosclerotic left internal thoracic arteries (LITA)) in the Tampere Vascular Study." -circulation_biomarker_diagnosis_up hsa-mir-210 Atherosclerosis 21820659 "miR-21, miR-210, miR-34a, and miR-146a/b are up-regulated in human atherosclerotic plaques (compared to non-atherosclerotic left internal thoracic arteries (LITA)) in the Tampere Vascular Study." -circulation_biomarker_diagnosis_up hsa-mir-34a Atherosclerosis 21820659 "miR-21, miR-210, miR-34a, and miR-146a/b are up-regulated in human atherosclerotic plaques (compared to non-atherosclerotic left internal thoracic arteries (LITA)) in the Tampere Vascular Study." -circulation_biomarker_diagnosis_up hsa-mir-146a Multiple Sclerosis 21875645 "In peripheral mononuclear cells, a statistically significant increased expression of miR-21, miR-146a and -b was observed in relapsing remitting (RR)MS patients as compared with controls." -circulation_biomarker_diagnosis_up hsa-mir-146b Multiple Sclerosis 21875645 "In peripheral mononuclear cells, a statistically significant increased expression of miR-21, miR-146a and -b was observed in relapsing remitting (RR)MS patients as compared with controls." -circulation_biomarker_diagnosis_up hsa-mir-21 Multiple Sclerosis 21875645 "In peripheral mononuclear cells, a statistically significant increased expression of miR-21, miR-146a and -b was observed in relapsing remitting (RR)MS patients as compared with controls." -circulation_biomarker_diagnosis_up hsa-mir-133a-1 Myocardial Infarction 21881276 "The miR-133 levels in plasma from AMI patients exhibited a 4.4-fold increase compared with control subjects (p=0.006). Moreover, the increased miR-133 levels in whole blood were comparable with those in plasma samples." -circulation_biomarker_diagnosis_up hsa-mir-133a-2 Myocardial Infarction 21881276 "The miR-133 levels in plasma from AMI patients exhibited a 4.4-fold increase compared with control subjects (p=0.006). Moreover, the increased miR-133 levels in whole blood were comparable with those in plasma samples." -circulation_biomarker_diagnosis_up hsa-mir-133b Myocardial Infarction 21881276 "The miR-133 levels in plasma from AMI patients exhibited a 4.4-fold increase compared with control subjects (p=0.006). Moreover, the increased miR-133 levels in whole blood were comparable with those in plasma samples." -circulation_biomarker_diagnosis_up hsa-mir-328 Myocardial Infarction 21881276 "miR-328 levels in plasma and whole blood of AMI patients were markedly increased by 10.9-fold and 16.1-fold, respectively, compared to those in control subjects (p=0.033 and p<0.001)." -circulation_biomarker_diagnosis_up hsa-mir-142 "Scleroderma, Systemic" 21883400 "Serum miR-142-3p levels in patients with SSc (systemic sclerosis) were significantly higher than in patients with SSD (scleroderma spectrum disorder), SLE (systemic lupus erythematosus) or DM (dermatomyositis), and healthy control groups. Patients with increased miR-142-3p levels tended to have a short sublingual frenulum." -circulation_biomarker_diagnosis_up hsa-mir-122 "Fatty Liver, Alcoholic" 21886843 "Serum levels of miR-122, miR-34a and miR-16 were significantly higher in NAFLD patients than in controls. miR-122 and miR-34a levels positively correlated with disease severity from simple steatosis to steatohepatitis." -circulation_biomarker_diagnosis_up hsa-mir-122 Hepatitis C Virus Infection 21886843 "Extracellular levels of circulating miRNAs, miR-122, miR-34a and to a lesser extent miR-16, steadily increased during the course of HCV infection." -circulation_biomarker_diagnosis_up hsa-mir-16-1 "Fatty Liver, Alcoholic" 21886843 "Serum levels of miR-122, miR-34a and miR-16 were significantly higher in NAFLD patients than in controls. miR-122 and miR-34a levels positively correlated with disease severity from simple steatosis to steatohepatitis." -circulation_biomarker_diagnosis_up hsa-mir-16-1 Hepatitis C Virus Infection 21886843 "Extracellular levels of circulating miRNAs, miR-122, miR-34a and to a lesser extent miR-16, steadily increased during the course of HCV infection." -circulation_biomarker_diagnosis_up hsa-mir-16-2 "Fatty Liver, Alcoholic" 21886843 "Serum levels of miR-122, miR-34a and miR-16 were significantly higher in NAFLD patients than in controls. miR-122 and miR-34a levels positively correlated with disease severity from simple steatosis to steatohepatitis." -circulation_biomarker_diagnosis_up hsa-mir-16-2 Hepatitis C Virus Infection 21886843 "Extracellular levels of circulating miRNAs, miR-122, miR-34a and to a lesser extent miR-16, steadily increased during the course of HCV infection." -circulation_biomarker_diagnosis_up hsa-mir-34a "Fatty Liver, Alcoholic" 21886843 "Serum levels of miR-122, miR-34a and miR-16 were significantly higher in NAFLD patients than in controls. miR-122 and miR-34a levels positively correlated with disease severity from simple steatosis to steatohepatitis." -circulation_biomarker_diagnosis_up hsa-mir-34a Hepatitis C Virus Infection 21886843 "Extracellular levels of circulating miRNAs, miR-122, miR-34a and to a lesser extent miR-16, steadily increased during the course of HCV infection." -circulation_biomarker_diagnosis_up hsa-mir-155 Lung Neoplasms 21904633 "The levels of miR-155, miR-197, and miR-182 in the plasma of lung cancer including stage I patients were significantly elevated compared with controls (P<0.001). The combination of these 3 miRNAs yielded 81.33% sensitivity and 86.76% specificity in discriminating lung cancer patients from controls. The levels of miR-155 and miR-197 were higher in the plasma from lung cancer patients with metastasis than in those without metastasis (P<0.05) and were significantly decreased in responsive patients during chemotherapy (P<0.001)." -circulation_biomarker_diagnosis_up hsa-mir-182 Lung Neoplasms 21904633 "The levels of miR-155, miR-197, and miR-182 in the plasma of lung cancer including stage I patients were significantly elevated compared with controls (P<0.001). The combination of these 3 miRNAs yielded 81.33% sensitivity and 86.76% specificity in discriminating lung cancer patients from controls. The levels of miR-155 and miR-197 were higher in the plasma from lung cancer patients with metastasis than in those without metastasis (P<0.05) and were significantly decreased in responsive patients during chemotherapy (P<0.001)." -circulation_biomarker_diagnosis_up hsa-mir-197 Lung Neoplasms 21904633 "The levels of miR-155, miR-197, and miR-182 in the plasma of lung cancer including stage I patients were significantly elevated compared with controls (P<0.001). The combination of these 3 miRNAs yielded 81.33% sensitivity and 86.76% specificity in discriminating lung cancer patients from controls. The levels of miR-155 and miR-197 were higher in the plasma from lung cancer patients with metastasis than in those without metastasis (P<0.05) and were significantly decreased in responsive patients during chemotherapy (P<0.001)." -circulation_biomarker_diagnosis_up hsa-let-7e Hypertension 21924071 "MiR-296-5p (Fold change 0.47, P = 0.013) and miR-133b (Fold change 0.57, P = 0.033) were consistently down-regulated in the patient plasma, whereas let-7e (Fold change 1.62, P = 0.009) and hcmv-miR-UL112 (Fold change 2.72, P = 0.004), one human cytomegalovirus encoded microRNAs, were up-regulated in the patient samples." -circulation_biomarker_diagnosis_up hsa-mir-134 Pulmonary Embolism 21943159 "Plasma miRNA-134 (miR-134) level was significantly higher in the APE patients than in the healthy controls or non-APE patients. The ROC curve showed that plasma miR-134 was a specific diagnostic predictor of APE with an area under the curve of 0.833 (95% confidence interval, 0.737 to 0.929; P<0.001). The findings indicated that plasma miR-134 could be an important biomarker for the diagnosis of APE." -circulation_biomarker_diagnosis_up hsa-mir-29a Liver Cirrhosis 21946200 MiR-29 directly suppresses the expression of a variety of extracellular matrix components and regulates signaling pathways associated with fibrosis. The serum level of miR-29 in patients with liver disease is consistent with the degree of liver cirrhosis. -circulation_biomarker_diagnosis_up hsa-mir-29b-1 Liver Cirrhosis 21946200 MiR-29 directly suppresses the expression of a variety of extracellular matrix components and regulates signaling pathways associated with fibrosis. The serum level of miR-29 in patients with liver disease is consistent with the degree of liver cirrhosis. -circulation_biomarker_diagnosis_up hsa-mir-29b-2 Liver Cirrhosis 21946200 MiR-29 directly suppresses the expression of a variety of extracellular matrix components and regulates signaling pathways associated with fibrosis. The serum level of miR-29 in patients with liver disease is consistent with the degree of liver cirrhosis. -circulation_biomarker_diagnosis_up hsa-mir-29c Liver Cirrhosis 21946200 MiR-29 directly suppresses the expression of a variety of extracellular matrix components and regulates signaling pathways associated with fibrosis. The serum level of miR-29 in patients with liver disease is consistent with the degree of liver cirrhosis. -circulation_biomarker_diagnosis_up hsa-mir-106b "Carcinoma, Renal Cell" 21984948 "Up-regulation in serum and tissue of RCC patients: miR-7-1*, miR-93, miR-106b*, miR-210, miR-320b, miR-1233 and miR-1290" -circulation_biomarker_diagnosis_up hsa-mir-1233-1 "Carcinoma, Renal Cell" 21984948 "Up-regulation in serum and tissue of RCC patients: miR-7-1*, miR-93, miR-106b*, miR-210, miR-320b, miR-1233 and miR-1290" -circulation_biomarker_diagnosis_up hsa-mir-1233-2 "Carcinoma, Renal Cell" 21984948 "Up-regulation in serum and tissue of RCC patients: miR-7-1*, miR-93, miR-106b*, miR-210, miR-320b, miR-1233 and miR-1290" -circulation_biomarker_diagnosis_up hsa-mir-1290 "Carcinoma, Renal Cell" 21984948 "Up-regulation in serum and tissue of RCC patients: miR-7-1*, miR-93, miR-106b*, miR-210, miR-320b, miR-1233 and miR-1290" -circulation_biomarker_diagnosis_up hsa-mir-210 "Carcinoma, Renal Cell" 21984948 "Up-regulation in serum and tissue of RCC patients: miR-7-1*, miR-93, miR-106b*, miR-210, miR-320b, miR-1233 and miR-1290" -circulation_biomarker_diagnosis_up hsa-mir-320b-1 "Carcinoma, Renal Cell" 21984948 "Up-regulation in serum and tissue of RCC patients: miR-7-1*, miR-93, miR-106b*, miR-210, miR-320b, miR-1233 and miR-1290" -circulation_biomarker_diagnosis_up hsa-mir-320b-2 "Carcinoma, Renal Cell" 21984948 "Up-regulation in serum and tissue of RCC patients: miR-7-1*, miR-93, miR-106b*, miR-210, miR-320b, miR-1233 and miR-1290" -circulation_biomarker_diagnosis_up hsa-mir-7-1 "Carcinoma, Renal Cell" 21984948 "Up-regulation in serum and tissue of RCC patients: miR-7-1*, miR-93, miR-106b*, miR-210, miR-320b, miR-1233 and miR-1290" -circulation_biomarker_diagnosis_up hsa-mir-93 "Carcinoma, Renal Cell" 21984948 "Up-regulation in serum and tissue of RCC patients: miR-7-1*, miR-93, miR-106b*, miR-210, miR-320b, miR-1233 and miR-1290" -circulation_biomarker_diagnosis_up hsa-mir-155 "Tuberculosis, Pulmonary" 22037148 Analysis of microRNA expression profiling identifies miR-155 and miR-155* as potential diagnostic markers for active tuberculosis. -circulation_biomarker_diagnosis_up hsa-mir-18a Pancreatic Neoplasms 22045190 The expression of miR-18a was significantly higher in pancreatic cancer tissues (P=0.012) and pancreatic cancer cell lines (P=0.015) than in normal tissues and fibroblasts. Plasma concentrations of miR-18a were significantly higher in pancreatic cancer patients than in controls (P<0.0001). The value of the area under the receiver-operating characteristic curve (AUC) was 0.9369. Plasma levels of miR-18a were significantly lower in postoperative samples than in preoperative samples (P=0.0077). -circulation_biomarker_diagnosis_up hsa-mir-192 Liver Injury 22045675 Serum miR-122 and miR-192 were substantially higher in APAP-ALI patients. -circulation_biomarker_diagnosis_up hsa-mir-223 "Leukemia, Promyelocytic, Acute" 22053279 overexpression -circulation_biomarker_diagnosis_up hsa-mir-326 "Diabetes Mellitus, Type 1" 22069274 Increased expression of microRNA miR-326 in type 1 diabetic patients with ongoing islet autoimmunity. -circulation_biomarker_diagnosis_up hsa-mir-210 Preeclampsia 22095477 Serum expression level of miR-210 was up-regulated in preeclampsia patients. -circulation_biomarker_diagnosis_up hsa-mir-100 "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 22099053 "A significant association was observed between higher expression levels of miR-196b and T-ALL, miR-100 and patients with low white blood cell count at diagnosis and t(12;21) positive ALL." -circulation_biomarker_diagnosis_up hsa-mir-196b "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 22099053 "A significant association was observed between higher expression levels of miR-196b and T-ALL, miR-100 and patients with low white blood cell count at diagnosis and t(12;21) positive ALL." -circulation_biomarker_diagnosis_up hsa-mir-22 Heart Failure 22120965 significantly increased serum level -circulation_biomarker_diagnosis_up hsa-mir-320a Heart Failure 22120965 significantly increased serum level -circulation_biomarker_diagnosis_up hsa-mir-423 Heart Failure 22120965 miR-423-5p: significantly increased serum level -circulation_biomarker_diagnosis_up hsa-mir-92b Heart Failure 22120965 significantly increased serum level -circulation_biomarker_diagnosis_up hsa-mir-1266 Psoriasis 22133505 Increased serum levels of miR-1266 in patients with psoriasis vulgaris. -circulation_biomarker_diagnosis_up hsa-mir-1 Cardiovascular Diseases [unspecific] 22135162 miR-1 and miR-133 are highly expressed in cardiomyocytes and their precursors and regulate cardiomyogenesis. -circulation_biomarker_diagnosis_up hsa-mir-133 Cardiovascular Diseases [unspecific] 22135162 miR-1 and miR-133 are highly expressed in cardiomyocytes and their precursors and regulate cardiomyogenesis. -circulation_biomarker_diagnosis_up hsa-mir-140 Osteoarthritis 22143896 the expression of both miR-140-5p and miR-455-3p was increased in OA cartilage. -circulation_biomarker_diagnosis_up hsa-mir-455 Osteoarthritis 22143896 the expression of both miR-140-5p and miR-455-3p was increased in OA cartilage. -circulation_biomarker_diagnosis_up hsa-mir-92a-1 Myocardial Infarction 22153007 "In STEMI (ST-segment elevation myocardial infarction) patients, the expression of circulating miR-92a is up-regulated. PCI therapy may suppress such up-regulation. Survival rate is higher in patients showing down-regulation of miR-92a. Our data suggest that miR-92a might have potential for diagnosis and therapeutic application in the prevention and treatment of STEMI." -circulation_biomarker_diagnosis_up hsa-mir-92a-2 Myocardial Infarction 22153007 "In STEMI (ST-segment elevation myocardial infarction) patients, the expression of circulating miR-92a is up-regulated. PCI therapy may suppress such up-regulation. Survival rate is higher in patients showing down-regulation of miR-92a. Our data suggest that miR-92a might have potential for diagnosis and therapeutic application in the prevention and treatment of STEMI." -circulation_biomarker_diagnosis_up hsa-mir-103a-1 Preeclampsia 22187671 "Seven microRNAs, namely miR-24, miR-26a, miR-103, miR-130b, miR-181a, miR-342-3p, and miR-574-5p, were validated to be elevated in plasma from severe pre-eclamptic pregnancies by using real-time quantitative stem-loop reverse-transcription polymerase chain reaction analysis." -circulation_biomarker_diagnosis_up hsa-mir-103a-2 Preeclampsia 22187671 "Seven microRNAs, namely miR-24, miR-26a, miR-103, miR-130b, miR-181a, miR-342-3p, and miR-574-5p, were validated to be elevated in plasma from severe pre-eclamptic pregnancies by using real-time quantitative stem-loop reverse-transcription polymerase chain reaction analysis." -circulation_biomarker_diagnosis_up hsa-mir-103b-1 Preeclampsia 22187671 "Seven microRNAs, namely miR-24, miR-26a, miR-103, miR-130b, miR-181a, miR-342-3p, and miR-574-5p, were validated to be elevated in plasma from severe pre-eclamptic pregnancies by using real-time quantitative stem-loop reverse-transcription polymerase chain reaction analysis." -circulation_biomarker_diagnosis_up hsa-mir-103b-2 Preeclampsia 22187671 "Seven microRNAs, namely miR-24, miR-26a, miR-103, miR-130b, miR-181a, miR-342-3p, and miR-574-5p, were validated to be elevated in plasma from severe pre-eclamptic pregnancies by using real-time quantitative stem-loop reverse-transcription polymerase chain reaction analysis." -circulation_biomarker_diagnosis_up hsa-mir-130b Preeclampsia 22187671 "Seven microRNAs, namely miR-24, miR-26a, miR-103, miR-130b, miR-181a, miR-342-3p, and miR-574-5p, were validated to be elevated in plasma from severe pre-eclamptic pregnancies by using real-time quantitative stem-loop reverse-transcription polymerase chain reaction analysis." -circulation_biomarker_diagnosis_up hsa-mir-181a-1 Preeclampsia 22187671 "Seven microRNAs, namely miR-24, miR-26a, miR-103, miR-130b, miR-181a, miR-342-3p, and miR-574-5p, were validated to be elevated in plasma from severe pre-eclamptic pregnancies by using real-time quantitative stem-loop reverse-transcription polymerase chain reaction analysis." -circulation_biomarker_diagnosis_up hsa-mir-181a-2 Preeclampsia 22187671 "Seven microRNAs, namely miR-24, miR-26a, miR-103, miR-130b, miR-181a, miR-342-3p, and miR-574-5p, were validated to be elevated in plasma from severe pre-eclamptic pregnancies by using real-time quantitative stem-loop reverse-transcription polymerase chain reaction analysis." -circulation_biomarker_diagnosis_up hsa-mir-24-1 Preeclampsia 22187671 "Seven microRNAs, namely miR-24, miR-26a, miR-103, miR-130b, miR-181a, miR-342-3p, and miR-574-5p, were validated to be elevated in plasma from severe pre-eclamptic pregnancies by using real-time quantitative stem-loop reverse-transcription polymerase chain reaction analysis." -circulation_biomarker_diagnosis_up hsa-mir-24-2 Preeclampsia 22187671 "Seven microRNAs, namely miR-24, miR-26a, miR-103, miR-130b, miR-181a, miR-342-3p, and miR-574-5p, were validated to be elevated in plasma from severe pre-eclamptic pregnancies by using real-time quantitative stem-loop reverse-transcription polymerase chain reaction analysis." -circulation_biomarker_diagnosis_up hsa-mir-26a-1 Preeclampsia 22187671 "Seven microRNAs, namely miR-24, miR-26a, miR-103, miR-130b, miR-181a, miR-342-3p, and miR-574-5p, were validated to be elevated in plasma from severe pre-eclamptic pregnancies by using real-time quantitative stem-loop reverse-transcription polymerase chain reaction analysis." -circulation_biomarker_diagnosis_up hsa-mir-26a-2 Preeclampsia 22187671 "Seven microRNAs, namely miR-24, miR-26a, miR-103, miR-130b, miR-181a, miR-342-3p, and miR-574-5p, were validated to be elevated in plasma from severe pre-eclamptic pregnancies by using real-time quantitative stem-loop reverse-transcription polymerase chain reaction analysis." -circulation_biomarker_diagnosis_up hsa-mir-342 Preeclampsia 22187671 "Seven microRNAs, namely miR-24, miR-26a, miR-103, miR-130b, miR-181a, miR-342-3p, and miR-574-5p, were validated to be elevated in plasma from severe pre-eclamptic pregnancies by using real-time quantitative stem-loop reverse-transcription polymerase chain reaction analysis." -circulation_biomarker_diagnosis_up hsa-mir-574 Preeclampsia 22187671 "Seven microRNAs, namely miR-24, miR-26a, miR-103, miR-130b, miR-181a, miR-342-3p, and miR-574-5p, were validated to be elevated in plasma from severe pre-eclamptic pregnancies by using real-time quantitative stem-loop reverse-transcription polymerase chain reaction analysis." -circulation_biomarker_diagnosis_up hsa-mir-22 Multiple Sclerosis 22231906 "Six plasma miRNA (miR-614, miR-572, miR-648, miR-1826, miR-422a and miR-22) that were significantly up-regulated and one plasma miRNA (miR-1979) that was significantly down-regulated in MS individuals." -circulation_biomarker_diagnosis_up hsa-mir-422a Multiple Sclerosis 22231906 "Six plasma miRNA (miR-614, miR-572, miR-648, miR-1826, miR-422a and miR-22) that were significantly up-regulated and one plasma miRNA (miR-1979) that was significantly down-regulated in MS individuals." -circulation_biomarker_diagnosis_up hsa-mir-572 Multiple Sclerosis 22231906 "Six plasma miRNA (miR-614, miR-572, miR-648, miR-1826, miR-422a and miR-22) that were significantly up-regulated and one plasma miRNA (miR-1979) that was significantly down-regulated in MS individuals." -circulation_biomarker_diagnosis_up hsa-mir-614 Multiple Sclerosis 22231906 "Six plasma miRNA (miR-614, miR-572, miR-648, miR-1826, miR-422a and miR-22) that were significantly up-regulated and one plasma miRNA (miR-1979) that was significantly down-regulated in MS individuals." -circulation_biomarker_diagnosis_up hsa-mir-648 Multiple Sclerosis 22231906 "Six plasma miRNA (miR-614, miR-572, miR-648, miR-1826, miR-422a and miR-22) that were significantly up-regulated and one plasma miRNA (miR-1979) that was significantly down-regulated in MS individuals." -circulation_biomarker_diagnosis_up hsa-let-7a-1 Breast Neoplasms 22242178 let-7a* is up-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_up hsa-let-7a-2 Breast Neoplasms 22242178 let-7a* is up-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_up hsa-let-7a-3 Breast Neoplasms 22242178 let-7a* is up-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_up hsa-mir-106b Breast Neoplasms 22242178 The miRNA is up-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_up hsa-mir-1323 Breast Neoplasms 22242178 The miRNA is up-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_up hsa-mir-202 Breast Neoplasms 22242178 The miRNA is up-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_up hsa-mir-335 Breast Neoplasms 22242178 The miRNA is up-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_up hsa-mir-4257 Breast Neoplasms 22242178 The miRNA is up-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_up hsa-mir-4306 Breast Neoplasms 22242178 The miRNA is up-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_up hsa-mir-497 Breast Neoplasms 22242178 The miRNA is up-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_up hsa-mir-516b-1 Breast Neoplasms 22242178 The miRNA is up-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_up hsa-mir-516b-2 Breast Neoplasms 22242178 The miRNA is up-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_up hsa-mir-922 Breast Neoplasms 22242178 The miRNA is up-regulated in whole blood of breast cancer patients -circulation_biomarker_diagnosis_up hsa-mir-103a-1 Mesothelioma 22253921 miR-103 was identified as a potential biomarker for malignant mesothelioma -circulation_biomarker_diagnosis_up hsa-mir-103a-2 Mesothelioma 22253921 miR-103 was identified as a potential biomarker for malignant mesothelioma -circulation_biomarker_diagnosis_up hsa-mir-125b "Leukemia, Lymphoblastic" 22335948 "These three subtypes of leukemia could be identified by unsupervised hierarchical cluster analysis of microRNA expression and had specific up-regulation of miR-335, miR-126 and miR-125b, respectively." -circulation_biomarker_diagnosis_up hsa-mir-126 "Leukemia, Lymphoblastic" 22335948 "These three subtypes of leukemia could be identified by unsupervised hierarchical cluster analysis of microRNA expression and had specific up-regulation of miR-335, miR-126 and miR-125b, respectively." -circulation_biomarker_diagnosis_up hsa-mir-335 "Leukemia, Lymphoblastic" 22335948 "These three subtypes of leukemia could be identified by unsupervised hierarchical cluster analysis of microRNA expression and had specific up-regulation of miR-335, miR-126 and miR-125b, respectively." -circulation_biomarker_diagnosis_up hsa-mir-20a Breast Neoplasms 22350790 "Levels of preoperative serum miR-20a and miR-21 were significantly higher in patients with breast cancer and benign disease than in healthy women (p = 0.0001), but only serum miR-214 could discriminate malignant from benign tumors and healthy controls (p = 0.0001) with an area under the curve of 0.878 and 0.883 in ROC analysis, respectively." -circulation_biomarker_diagnosis_up hsa-mir-21 Breast Neoplasms 22350790 "Levels of preoperative serum miR-20a and miR-21 were significantly higher in patients with breast cancer and benign disease than in healthy women (p = 0.0001), but only serum miR-214 could discriminate malignant from benign tumors and healthy controls (p = 0.0001) with an area under the curve of 0.878 and 0.883 in ROC analysis, respectively." -circulation_biomarker_diagnosis_up hsa-mir-214 Breast Neoplasms 22350790 "Levels of preoperative serum miR-20a and miR-21 were significantly higher in patients with breast cancer and benign disease than in healthy women (p = 0.0001), but only serum miR-214 could discriminate malignant from benign tumors and healthy controls (p = 0.0001) with an area under the curve of 0.878 and 0.883 in ROC analysis, respectively." -circulation_biomarker_diagnosis_up hsa-mir-21 Esophageal Neoplasms 22354855 "Serum concentration of miRNA-21 in ESCC patients was significantly higher than that in healthy controls (P<0.001). A significant reduction in the serum miR-21 levels was observed in the postoperative samples versus the preoperative samples (P=0.003). Furthermore, miRNA-21 levels were significantly reduced in ESCC patients who responded to chemotherapy (P=0.003), whereas no significant change was observed in the non-responders." -circulation_biomarker_diagnosis_up hsa-mir-145 Cerebral Ischemia 22370881 Circulatory microRNA-145 expression is increased in cerebral ischemia. -circulation_biomarker_diagnosis_up hsa-mir-106a Crohn Disease 22386737 The miRNA showed significantly higher levels in the blood from patients with CD compared with the healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-107 Crohn Disease 22386737 The miRNA showed significantly higher levels in the blood from patients with CD compared with the healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-126 Crohn Disease 22386737 The miRNA showed significantly higher levels in the blood from patients with CD compared with the healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-16-1 Crohn Disease 22386737 The miRNA showed significantly higher levels in the blood from patients with CD compared with the healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-16-2 Crohn Disease 22386737 The miRNA showed significantly higher levels in the blood from patients with CD compared with the healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-191 Crohn Disease 22386737 The miRNA showed significantly higher levels in the blood from patients with CD compared with the healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-199a-1 Crohn Disease 22386737 The miRNA showed significantly higher levels in the blood from patients with CD compared with the healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-199a-2 Crohn Disease 22386737 The miRNA showed significantly higher levels in the blood from patients with CD compared with the healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-200c Crohn Disease 22386737 The miRNA showed significantly higher levels in the blood from patients with CD compared with the healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-23a Crohn Disease 22386737 The miRNA showed significantly higher levels in the blood from patients with CD compared with the healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-29a Crohn Disease 22386737 The miRNA showed significantly higher levels in the blood from patients with CD compared with the healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-362 Crohn Disease 22386737 The miRNA showed significantly higher levels in the blood from patients with CD compared with the healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-532 Crohn Disease 22386737 The miRNA showed significantly higher levels in the blood from patients with CD compared with the healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-103a-1 Breast Neoplasms 22387599 significantly increased in serum of breast cancer patients. -circulation_biomarker_diagnosis_up hsa-mir-222 Breast Neoplasms 22387599 significantly increased in serum of breast cancer patients. -circulation_biomarker_diagnosis_up hsa-mir-23a Breast Neoplasms 22387599 significantly increased in serum of breast cancer patients. -circulation_biomarker_diagnosis_up hsa-mir-23b Breast Neoplasms 22387599 significantly increased in serum of breast cancer patients. -circulation_biomarker_diagnosis_up hsa-mir-24-1 Breast Neoplasms 22387599 significantly increased in serum of breast cancer patients. -circulation_biomarker_diagnosis_up hsa-mir-25 Breast Neoplasms 22387599 significantly increased in serum of breast cancer patients. -circulation_biomarker_diagnosis_up hsa-mir-29a Breast Neoplasms 22387599 significantly increased in serum of breast cancer patients. -circulation_biomarker_diagnosis_up hsa-mir-210 "Carcinoma, Hepatocellular" 22387901 "Downregulation of miR-210 expression inhibits proliferation, induces apoptosis and enhances radiosensitivity in hypoxic human hepatoma cells in vitro." -circulation_biomarker_diagnosis_up hsa-mir-106b Eosinophilic Esophagitis 22391115 miR-106b*: upregulated -circulation_biomarker_diagnosis_up hsa-mir-132 Eosinophilic Esophagitis 22391115 upregulated -circulation_biomarker_diagnosis_up hsa-mir-142 Eosinophilic Esophagitis 22391115 upregulated -circulation_biomarker_diagnosis_up hsa-mir-146a Eosinophilic Esophagitis 22391115 "Plasma analysis of the most upregulated esophageal miRNAs identified miR-146a, miR-146b, and miR-223 as the most differentially expressed miRNAs in the plasma." -circulation_biomarker_diagnosis_up hsa-mir-146b Eosinophilic Esophagitis 22391115 "Plasma analysis of the most upregulated esophageal miRNAs identified miR-146a, miR-146b, and miR-223 as the most differentially expressed miRNAs in the plasma." -circulation_biomarker_diagnosis_up hsa-mir-21 Eosinophilic Esophagitis 22391115 "One of the most upregulated miRNA, which strongly correlated with esophageal eosinophil levels." -circulation_biomarker_diagnosis_up hsa-mir-212 Eosinophilic Esophagitis 22391115 upregulated -circulation_biomarker_diagnosis_up hsa-mir-222 Eosinophilic Esophagitis 22391115 miR-222*: upregulated -circulation_biomarker_diagnosis_up hsa-mir-223 Eosinophilic Esophagitis 22391115 "One of the most upregulated miRNA, which strongly correlated with esophageal eosinophil levels. And miR-223 is one of the most differentially expressed miRNAs in the plasma." -circulation_biomarker_diagnosis_up hsa-mir-29b-1 Eosinophilic Esophagitis 22391115 upregulated -circulation_biomarker_diagnosis_up hsa-mir-29b-2 Eosinophilic Esophagitis 22391115 upregulated -circulation_biomarker_diagnosis_up hsa-mir-339 Eosinophilic Esophagitis 22391115 miR-339-5p: upregulated -circulation_biomarker_diagnosis_up hsa-mir-592 Eosinophilic Esophagitis 22391115 upregulated -circulation_biomarker_diagnosis_up hsa-mir-7-1 Eosinophilic Esophagitis 22391115 upregulated -circulation_biomarker_diagnosis_up hsa-mir-7-2 Eosinophilic Esophagitis 22391115 upregulated -circulation_biomarker_diagnosis_up hsa-mir-7-3 Eosinophilic Esophagitis 22391115 upregulated -circulation_biomarker_diagnosis_up hsa-mir-92a-1 Eosinophilic Esophagitis 22391115 miR-92a-1*: upregulated -circulation_biomarker_diagnosis_up hsa-mir-323a Ectopic Pregnancy 22395025 "Concentrations of serum hCG, progesterone, miR-517a, miR-519d, and miR-525-3p were significantly lower in EP and SA cases than in VIP cases. In contrast, the concentration of miR-323-3p was significantly increased in EP cases, compared with SA and VIP cases. As a single marker, miR-323-3p had the highest sensitivity of 37.0% (at a fixed specificity of 90%)." -circulation_biomarker_diagnosis_up hsa-mir-130b "Carcinoma, Hepatocellular" 22403344 "Serum miR-15b, miR-21, miR-130b and miR-183 highly expressed in tumours. Combined miR-15b and miR-130b demonstrated as a classifier for HCC detection, yielding a receiver operating characteristic curve area of 0.98 (98.2% sensitivity and 91.5% specificity)." -circulation_biomarker_diagnosis_up hsa-mir-15b "Carcinoma, Hepatocellular" 22403344 "Serum miR-15b, miR-21, miR-130b and miR-183 highly expressed in tumours. Combined miR-15b and miR-130b demonstrated as a classifier for HCC detection, yielding a receiver operating characteristic curve area of 0.98 (98.2% sensitivity and 91.5% specificity)." -circulation_biomarker_diagnosis_up hsa-mir-183 "Carcinoma, Hepatocellular" 22403344 "Serum miR-15b, miR-21, miR-130b and miR-183 highly expressed in tumours. Combined miR-15b and miR-130b demonstrated as a classifier for HCC detection, yielding a receiver operating characteristic curve area of 0.98 (98.2% sensitivity and 91.5% specificity)." -circulation_biomarker_diagnosis_up hsa-mir-21 "Carcinoma, Hepatocellular" 22403344 "Serum miR-15b, miR-21, miR-130b and miR-183 highly expressed in tumours. Combined miR-15b and miR-130b demonstrated as a classifier for HCC detection, yielding a receiver operating characteristic curve area of 0.98 (98.2% sensitivity and 91.5% specificity)." -circulation_biomarker_diagnosis_up hsa-mir-126 "Carcinoma, Renal Cell" 22440013 miR-126*: Up-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-134 "Carcinoma, Renal Cell" 22440013 Up-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-144 "Carcinoma, Renal Cell" 22440013 miR-144*: Up-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-151a "Carcinoma, Renal Cell" 22440013 miR-151-30: Up-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-151b "Carcinoma, Renal Cell" 22440013 miR-151-30: Up-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-203 "Carcinoma, Renal Cell" 22440013 Up-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-26b "Carcinoma, Renal Cell" 22440013 miR-26b*: Up-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-29c "Carcinoma, Renal Cell" 22440013 miR-29c*: Up-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-320a "Carcinoma, Renal Cell" 22440013 Up-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-339 "Carcinoma, Renal Cell" 22440013 miR-339-3p: Up-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-365a "Carcinoma, Renal Cell" 22440013 Up-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-365b "Carcinoma, Renal Cell" 22440013 Up-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-378a "Carcinoma, Renal Cell" 22440013 Up-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-425 "Carcinoma, Renal Cell" 22440013 miR-425*: Up-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-454 "Carcinoma, Renal Cell" 22440013 miR-454*: Up-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-571 "Carcinoma, Renal Cell" 22440013 Up-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-625 "Carcinoma, Renal Cell" 22440013 miR-625*: Up-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-629 "Carcinoma, Renal Cell" 22440013 Up-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-655 "Carcinoma, Renal Cell" 22440013 Up-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-760 "Carcinoma, Renal Cell" 22440013 Up-regulated in the blook serum of patients with renal cell carcinoma compared to healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-148a Multiple Myeloma 22447484 Plasma level was significantly upregulated in MM.High levels of miR-20a and miR-148a were related to shorter relapse-free survival. -circulation_biomarker_diagnosis_up hsa-mir-181a-1 Multiple Myeloma 22447484 Plasma level was significantly upregulated in MM. -circulation_biomarker_diagnosis_up hsa-mir-181a-2 Multiple Myeloma 22447484 Plasma level was significantly upregulated in MM. -circulation_biomarker_diagnosis_up hsa-mir-20a Multiple Myeloma 22447484 Plasma level was significantly upregulated in MM. -circulation_biomarker_diagnosis_up hsa-mir-221 Multiple Myeloma 22447484 Plasma level was significantly upregulated in MM.High levels of miR-20a and miR-148a were related to shorter relapse-free survival. -circulation_biomarker_diagnosis_up hsa-mir-625 Multiple Myeloma 22447484 Plasma level was significantly upregulated in MM. -circulation_biomarker_diagnosis_up hsa-mir-99b Multiple Myeloma 22447484 Plasma level was significantly upregulated in MM. -circulation_biomarker_diagnosis_up hsa-mir-29b "Leukemia, Lymphoblastic, Acute" 22456238 "BCR-ABL1 positive cases, in contrast to negative ones, were characterized by slightly, but still significantly, higher expression levels of miR-29b." -circulation_biomarker_diagnosis_up hsa-let-7e Thyroid Neoplasms 22472564 "The expression of serum let-7e, miR-151-5p, and miR-222 was significantly increased in PTC (papillary thyroid carcinomas ) cases relative to benign cases and healthy controls. Serum let-7e, miR-151-5p, and miR-222 levels were found to be well correlated with certain clinicopathological variables, such as nodal status, tumor size, multifocal lesion status, and Tumor-Node-Metastasis stage." -circulation_biomarker_diagnosis_up hsa-mir-151a Thyroid Neoplasms 22472564 "The expression of serum let-7e, miR-151-5p, and miR-222 was significantly increased in PTC (papillary thyroid carcinomas ) cases relative to benign cases and healthy controls. Serum let-7e, miR-151-5p, and miR-222 levels were found to be well correlated with certain clinicopathological variables, such as nodal status, tumor size, multifocal lesion status, and Tumor-Node-Metastasis stage." -circulation_biomarker_diagnosis_up hsa-mir-151b Thyroid Neoplasms 22472564 "The expression of serum let-7e, miR-151-5p, and miR-222 was significantly increased in PTC (papillary thyroid carcinomas ) cases relative to benign cases and healthy controls. Serum let-7e, miR-151-5p, and miR-222 levels were found to be well correlated with certain clinicopathological variables, such as nodal status, tumor size, multifocal lesion status, and Tumor-Node-Metastasis stage." -circulation_biomarker_diagnosis_up hsa-mir-222 Thyroid Neoplasms 22472564 "The expression of serum let-7e, miR-151-5p, and miR-222 was significantly increased in PTC (papillary thyroid carcinomas ) cases relative to benign cases and healthy controls. Serum let-7e, miR-151-5p, and miR-222 levels were found to be well correlated with certain clinicopathological variables, such as nodal status, tumor size, multifocal lesion status, and Tumor-Node-Metastasis stage." -circulation_biomarker_diagnosis_up hsa-mir-21 "Lymphoma, Non-Hodgkin" 22487708 B-cell activation induced microRNA-21 is elevated in circulating B cells preceding the diagnosis of AIDS-related non-Hodgkin lymphomas. -circulation_biomarker_diagnosis_up hsa-mir-155 "Adenocarcinoma, Pancreatic Ductal" 22513294 "Quantification by real-time quantitative polymerase chain reaction revealed that miR-155, miR-21, and miR-210 were higher in serum of PDAC rats,similar to plasma of patients with PDAC" -circulation_biomarker_diagnosis_up hsa-mir-21 "Adenocarcinoma, Pancreatic Ductal" 22513294 "Quantification by real-time quantitative polymerase chain reaction revealed that miR-155, miR-21, and miR-210 were higher in serum of PDAC rats,similar to plasma of patients with PDAC" -circulation_biomarker_diagnosis_up hsa-mir-210 "Adenocarcinoma, Pancreatic Ductal" 22513294 "Quantification by real-time quantitative polymerase chain reaction revealed that miR-155, miR-21, and miR-210 were higher in serum of PDAC rats,similar to plasma of patients with PDAC" -circulation_biomarker_diagnosis_up hsa-mir-378a "Carcinoma, Renal Cell" 22542158 The level of miR-378 was significantly increased in serum of ccRCC patients. -circulation_biomarker_diagnosis_up hsa-mir-378b "Carcinoma, Renal Cell" 22542158 The level of miR-378 was significantly increased in serum of ccRCC patients. -circulation_biomarker_diagnosis_up hsa-mir-378c "Carcinoma, Renal Cell" 22542158 The level of miR-378 was significantly increased in serum of ccRCC patients. -circulation_biomarker_diagnosis_up hsa-mir-378d-1 "Carcinoma, Renal Cell" 22542158 The level of miR-378 was significantly increased in serum of ccRCC patients. -circulation_biomarker_diagnosis_up hsa-mir-378d-2 "Carcinoma, Renal Cell" 22542158 The level of miR-378 was significantly increased in serum of ccRCC patients. -circulation_biomarker_diagnosis_up hsa-mir-378e "Carcinoma, Renal Cell" 22542158 The level of miR-378 was significantly increased in serum of ccRCC patients. -circulation_biomarker_diagnosis_up hsa-mir-378f "Carcinoma, Renal Cell" 22542158 The level of miR-378 was significantly increased in serum of ccRCC patients. -circulation_biomarker_diagnosis_up hsa-mir-378g "Carcinoma, Renal Cell" 22542158 The level of miR-378 was significantly increased in serum of ccRCC patients. -circulation_biomarker_diagnosis_up hsa-mir-378h "Carcinoma, Renal Cell" 22542158 The level of miR-378 was significantly increased in serum of ccRCC patients. -circulation_biomarker_diagnosis_up hsa-mir-378i "Carcinoma, Renal Cell" 22542158 The level of miR-378 was significantly increased in serum of ccRCC patients. -circulation_biomarker_diagnosis_up hsa-mir-122 Coronary Artery Disease 22587332 Plasma levels of lipometabolism-related miR-122 and miR-370 are increased in patients with hyperlipidemia and associated with coronary artery disease. -circulation_biomarker_diagnosis_up hsa-mir-122 Hyperlipidemia 22587332 Plasma levels of lipometabolism-related miR-122 and miR-370 are increased in patients with hyperlipidemia and associated with coronary artery disease. -circulation_biomarker_diagnosis_up hsa-mir-370 Coronary Artery Disease 22587332 Plasma levels of lipometabolism-related miR-122 and miR-370 are increased in patients with hyperlipidemia and associated with coronary artery disease. -circulation_biomarker_diagnosis_up hsa-mir-370 Hyperlipidemia 22587332 Plasma levels of lipometabolism-related miR-122 and miR-370 are increased in patients with hyperlipidemia and associated with coronary artery disease. -circulation_biomarker_diagnosis_up hsa-mir-103a-1 Breast Neoplasms 22588912 "The serum levels of miR-103 expression were significantly higher in the cancer patients than in the healthy control group (P<0.01). In the cancer patients, high miR-103 expression was significantly correlated to advanced clinical stage (P<0.05) and lymph node metastasis (P<0.05)." -circulation_biomarker_diagnosis_up hsa-mir-103a-2 Breast Neoplasms 22588912 "The serum levels of miR-103 expression were significantly higher in the cancer patients than in the healthy control group (P<0.01). In the cancer patients, high miR-103 expression was significantly correlated to advanced clinical stage (P<0.05) and lymph node metastasis (P<0.05)." -circulation_biomarker_diagnosis_up hsa-mir-103b-1 Breast Neoplasms 22588912 "The serum levels of miR-103 expression were significantly higher in the cancer patients than in the healthy control group (P<0.01). In the cancer patients, high miR-103 expression was significantly correlated to advanced clinical stage (P<0.05) and lymph node metastasis (P<0.05)." -circulation_biomarker_diagnosis_up hsa-mir-103b-2 Breast Neoplasms 22588912 "The serum levels of miR-103 expression were significantly higher in the cancer patients than in the healthy control group (P<0.01). In the cancer patients, high miR-103 expression was significantly correlated to advanced clinical stage (P<0.05) and lymph node metastasis (P<0.05)." -circulation_biomarker_diagnosis_up hsa-mir-625 Mesothelioma 22617246 Increased circulating miR-625-3p is a potential biomarker for patients with malignant pleural mesothelioma. -circulation_biomarker_diagnosis_up hsa-mir-126 Systemic Lupus Erythematosus 22683424 miR-126 was specifically enriched only in the blood of the SLE patients -circulation_biomarker_diagnosis_up hsa-mir-1-1 Myocardial Infarction 22719221 Increased miR-1 and decreased miR-126 in plasma from patients with AMI after the onset of symptoms compared with healthy subjects were found. -circulation_biomarker_diagnosis_up hsa-mir-1-2 Myocardial Infarction 22719221 Increased miR-1 and decreased miR-126 in plasma from patients with AMI after the onset of symptoms compared with healthy subjects were found. -circulation_biomarker_diagnosis_up hsa-mir-21 Esophageal Neoplasms 22799367 "Serum miR-21 expression in ESCC samples was significantly higher than in paired cancer-free samples (P <0.05). Metastasis was associated with mir-21 expression in serum (P <0.05), ESCC patients with metastasis having 8.4-fold higher serum miR-21 concentrations than healthy controls." -circulation_biomarker_diagnosis_up hsa-let-7b Breast Neoplasms 22821209 "Potential biomarker microRNAs were identified, including let-7b, let-7g and miR-18b, with higher circulating levels associated with tumours." -circulation_biomarker_diagnosis_up hsa-let-7g Breast Neoplasms 22821209 "Potential biomarker microRNAs were identified, including let-7b, let-7g and miR-18b, with higher circulating levels associated with tumours." -circulation_biomarker_diagnosis_up hsa-mir-18b Breast Neoplasms 22821209 "Potential biomarker microRNAs were identified, including let-7b, let-7g and miR-18b, with higher circulating levels associated with tumours." -circulation_biomarker_diagnosis_up hsa-mir-21 Gastric Neoplasms 22860003 "The plasma levels of miR-223 (P<0.001) and miR-21 (P<0.001) were significantly higher in GC patients than in healthy controls, while miR-218 (P<0.001) was significantly lower. The ROC analyses yielded the AUC values of 0.9089 for miR-223, 0.7944 for miR-21 and 0.7432 for miR-218, and combined ROC analysis revealed the highest AUC value of 0.9531 in discriminating GC patients from healthy controls." -circulation_biomarker_diagnosis_up hsa-mir-223 Gastric Neoplasms 22860003 "The plasma levels of miR-223 (P<0.001) and miR-21 (P<0.001) were significantly higher in GC patients than in healthy controls, while miR-218 (P<0.001) was significantly lower. The ROC analyses yielded the AUC values of 0.9089 for miR-223, 0.7944 for miR-21 and 0.7432 for miR-218, and combined ROC analysis revealed the highest AUC value of 0.9531 in discriminating GC patients from healthy controls." -circulation_biomarker_diagnosis_up hsa-mir-18a "Carcinoma, Hepatocellular" 22865399 Serum miR-18a was significantly higher in HBV patients with HCC than healthy controls (p < 0.01). -circulation_biomarker_diagnosis_up hsa-mir-21 Colorectal Carcinoma 22868372 "In the plasma group, miR-21 differentiated CRC patients from controls with 90% specificity and sensitivity." -circulation_biomarker_diagnosis_up hsa-mir-21 Aortic Stenosis 22882958 The myocardial and plasma levels of miR-21 were significantly higher in the AS patients compared with the controls and correlated directly with the echocardiographic mean transvalvular gradients. -circulation_biomarker_diagnosis_up hsa-mir-155 "Leukemia-Lymphoma, Adult T-Cell" 22884882 The high and low plasma levels of miR-155 and miR-126 changed with ATL stage. -circulation_biomarker_diagnosis_up hsa-mir-141 Prostate Neoplasms 22887127 "MiR-375, miR-378*, and miR-141 were significantly over-expressed in serum from CRPC patients compared with serum from low-risk localized patients, while miR-409-3p was significantly under-expressed. In prostate primary tumor samples, miR-375 and miR-141 also had significantly higher expression levels compared with those in normal prostate tissue." -circulation_biomarker_diagnosis_up hsa-mir-375 Prostate Neoplasms 22887127 "MiR-375, miR-378*, and miR-141 were significantly over-expressed in serum from CRPC patients compared with serum from low-risk localized patients, while miR-409-3p was significantly under-expressed. In prostate primary tumor samples, miR-375 and miR-141 also had significantly higher expression levels compared with those in normal prostate tissue." -circulation_biomarker_diagnosis_up hsa-mir-378a Prostate Neoplasms 22887127 "MiR-375, miR-378*, and miR-141 were significantly over-expressed in serum from CRPC patients compared with serum from low-risk localized patients, while miR-409-3p was significantly under-expressed. In prostate primary tumor samples, miR-375 and miR-141 also had significantly higher expression levels compared with those in normal prostate tissue." -circulation_biomarker_diagnosis_up hsa-mir-378b Prostate Neoplasms 22887127 "MiR-375, miR-378*, and miR-141 were significantly over-expressed in serum from CRPC patients compared with serum from low-risk localized patients, while miR-409-3p was significantly under-expressed. In prostate primary tumor samples, miR-375 and miR-141 also had significantly higher expression levels compared with those in normal prostate tissue." -circulation_biomarker_diagnosis_up hsa-mir-378c Prostate Neoplasms 22887127 "MiR-375, miR-378*, and miR-141 were significantly over-expressed in serum from CRPC patients compared with serum from low-risk localized patients, while miR-409-3p was significantly under-expressed. In prostate primary tumor samples, miR-375 and miR-141 also had significantly higher expression levels compared with those in normal prostate tissue." -circulation_biomarker_diagnosis_up hsa-mir-378d-1 Prostate Neoplasms 22887127 "MiR-375, miR-378*, and miR-141 were significantly over-expressed in serum from CRPC patients compared with serum from low-risk localized patients, while miR-409-3p was significantly under-expressed. In prostate primary tumor samples, miR-375 and miR-141 also had significantly higher expression levels compared with those in normal prostate tissue." -circulation_biomarker_diagnosis_up hsa-mir-378d-2 Prostate Neoplasms 22887127 "MiR-375, miR-378*, and miR-141 were significantly over-expressed in serum from CRPC patients compared with serum from low-risk localized patients, while miR-409-3p was significantly under-expressed. In prostate primary tumor samples, miR-375 and miR-141 also had significantly higher expression levels compared with those in normal prostate tissue." -circulation_biomarker_diagnosis_up hsa-mir-378e Prostate Neoplasms 22887127 "MiR-375, miR-378*, and miR-141 were significantly over-expressed in serum from CRPC patients compared with serum from low-risk localized patients, while miR-409-3p was significantly under-expressed. In prostate primary tumor samples, miR-375 and miR-141 also had significantly higher expression levels compared with those in normal prostate tissue." -circulation_biomarker_diagnosis_up hsa-mir-378f Prostate Neoplasms 22887127 "MiR-375, miR-378*, and miR-141 were significantly over-expressed in serum from CRPC patients compared with serum from low-risk localized patients, while miR-409-3p was significantly under-expressed. In prostate primary tumor samples, miR-375 and miR-141 also had significantly higher expression levels compared with those in normal prostate tissue." -circulation_biomarker_diagnosis_up hsa-mir-378g Prostate Neoplasms 22887127 "MiR-375, miR-378*, and miR-141 were significantly over-expressed in serum from CRPC patients compared with serum from low-risk localized patients, while miR-409-3p was significantly under-expressed. In prostate primary tumor samples, miR-375 and miR-141 also had significantly higher expression levels compared with those in normal prostate tissue." -circulation_biomarker_diagnosis_up hsa-mir-378h Prostate Neoplasms 22887127 "MiR-375, miR-378*, and miR-141 were significantly over-expressed in serum from CRPC patients compared with serum from low-risk localized patients, while miR-409-3p was significantly under-expressed. In prostate primary tumor samples, miR-375 and miR-141 also had significantly higher expression levels compared with those in normal prostate tissue." -circulation_biomarker_diagnosis_up hsa-mir-378i Prostate Neoplasms 22887127 "MiR-375, miR-378*, and miR-141 were significantly over-expressed in serum from CRPC patients compared with serum from low-risk localized patients, while miR-409-3p was significantly under-expressed. In prostate primary tumor samples, miR-375 and miR-141 also had significantly higher expression levels compared with those in normal prostate tissue." -circulation_biomarker_diagnosis_up hsa-mir-21 Glioblastoma 22891879 Plasma MicroRNA-21 in glioblastoma was significantly higher than controls (p = .02) and decreased significantly in 9 patients (p = .05). One patient with increasing microRNA-21 developed a histopathologically proven recurrence after the second sample collection. -circulation_biomarker_diagnosis_up hsa-mir-223 Prostate Neoplasms 22892455 An increase in serum miR-223 and a decrease in miR-125b and miR-146a were observed in group B. -circulation_biomarker_diagnosis_up hsa-mir-10b Breast Neoplasms 22906258 Serum Overexpression of MicroRNA-10b in Patients with Bone Metastatic Primary Breast Cancer. -circulation_biomarker_diagnosis_up hsa-mir-148b Breast Neoplasms 22927033 "Four miRNAs (miR-148b, miR-376c, miR-409-3p and miR-801) were shown to be significantly upregulated in the plasma of breast cancer patients." -circulation_biomarker_diagnosis_up hsa-mir-376c Breast Neoplasms 22927033 "Four miRNAs (miR-148b, miR-376c, miR-409-3p and miR-801) were shown to be significantly upregulated in the plasma of breast cancer patients." -circulation_biomarker_diagnosis_up hsa-mir-409 Breast Neoplasms 22927033 "Four miRNAs (miR-148b, miR-376c, miR-409-3p and miR-801) were shown to be significantly upregulated in the plasma of breast cancer patients." -circulation_biomarker_diagnosis_up hsa-mir-100 "Carcinoma, Lung, Non-Small-Cell" 22937028 "High expression of miR-100 and low expression of miRNA-93, miRNA-134, miRNA-151 and miRNA-345 were associated with poor survival in both the training and validation cohort." -circulation_biomarker_diagnosis_up hsa-mir-141 Breast Neoplasms 22952344 "CTC (circulating tumour cells)-positive had significantly higher levels of miR-141, miR-200a, miR-200b, miR-200c, miR-203, miR-210, miR-375 and miR-801 than CTC-negative MBC and controls (P < 0.00001), while miR-768-3p was present in lower amounts in MBC (metastatic breast cancer) cases (P < 0.05)." -circulation_biomarker_diagnosis_up hsa-mir-200a Breast Neoplasms 22952344 "CTC (circulating tumour cells)-positive had significantly higher levels of miR-141, miR-200a, miR-200b, miR-200c, miR-203, miR-210, miR-375 and miR-801 than CTC-negative MBC and controls (P < 0.00001), while miR-768-3p was present in lower amounts in MBC (metastatic breast cancer) cases (P < 0.05)." -circulation_biomarker_diagnosis_up hsa-mir-200b Breast Neoplasms 22952344 "CTC (circulating tumour cells)-positive had significantly higher levels of miR-141, miR-200a, miR-200b, miR-200c, miR-203, miR-210, miR-375 and miR-801 than CTC-negative MBC and controls (P < 0.00001), while miR-768-3p was present in lower amounts in MBC (metastatic breast cancer) cases (P < 0.05)." -circulation_biomarker_diagnosis_up hsa-mir-200c Breast Neoplasms 22952344 "CTC (circulating tumour cells)-positive had significantly higher levels of miR-141, miR-200a, miR-200b, miR-200c, miR-203, miR-210, miR-375 and miR-801 than CTC-negative MBC and controls (P < 0.00001), while miR-768-3p was present in lower amounts in MBC (metastatic breast cancer) cases (P < 0.05)." -circulation_biomarker_diagnosis_up hsa-mir-203 Breast Neoplasms 22952344 "CTC (circulating tumour cells)-positive had significantly higher levels of miR-141, miR-200a, miR-200b, miR-200c, miR-203, miR-210, miR-375 and miR-801 than CTC-negative MBC and controls (P < 0.00001), while miR-768-3p was present in lower amounts in MBC (metastatic breast cancer) cases (P < 0.05)." -circulation_biomarker_diagnosis_up hsa-mir-210 Breast Neoplasms 22952344 "CTC (circulating tumour cells)-positive had significantly higher levels of miR-141, miR-200a, miR-200b, miR-200c, miR-203, miR-210, miR-375 and miR-801 than CTC-negative MBC and controls (P < 0.00001), while miR-768-3p was present in lower amounts in MBC (metastatic breast cancer) cases (P < 0.05)." -circulation_biomarker_diagnosis_up hsa-mir-375 Breast Neoplasms 22952344 "CTC (circulating tumour cells)-positive had significantly higher levels of miR-141, miR-200a, miR-200b, miR-200c, miR-203, miR-210, miR-375 and miR-801 than CTC-negative MBC and controls (P < 0.00001), while miR-768-3p was present in lower amounts in MBC (metastatic breast cancer) cases (P < 0.05)." -circulation_biomarker_diagnosis_up hsa-mir-200c Gastric Neoplasms 22954417 The miR-200c blood expression levels in GC patients were significantly higher than in normal controls (p = 0.018). increased miR-200c levels are detected in the blood of gastric cancer patients. MiR-200c has the potential to be a predictor of progression and survival. -circulation_biomarker_diagnosis_up hsa-mir-151a Gastric Neoplasms 22956063 Plasma miRNA-199a-3p and miRNA-151-5p were significantly elevated (p < 0.05) and were significantly reduced after surgery (p < 0.05) in gastric cancer patients. -circulation_biomarker_diagnosis_up hsa-mir-151b Gastric Neoplasms 22956063 Plasma miRNA-199a-3p and miRNA-151-5p were significantly elevated (p < 0.05) and were significantly reduced after surgery (p < 0.05) in gastric cancer patients. -circulation_biomarker_diagnosis_up hsa-mir-199a-1 Gastric Neoplasms 22956063 Plasma miRNA-199a-3p and miRNA-151-5p were significantly elevated (p < 0.05) and were significantly reduced after surgery (p < 0.05) in gastric cancer patients. -circulation_biomarker_diagnosis_up hsa-mir-199a-2 Gastric Neoplasms 22956063 Plasma miRNA-199a-3p and miRNA-151-5p were significantly elevated (p < 0.05) and were significantly reduced after surgery (p < 0.05) in gastric cancer patients. -circulation_biomarker_diagnosis_up hsa-mir-126 Kidney Diseases [unspecific] 23070235 Circulating levels of inflammation-associated miR-155 and endothelial-enriched miR-126 in patients with end-stage renal disease -circulation_biomarker_diagnosis_up hsa-mir-224 Systemic Lupus Erythematosus 23199328 Decreased microRNA(miR)-145 and increased miR-224 expression in T cells from patients with systemic lupus erythematosus involved in lupus immunopathogenesis -circulation_biomarker_diagnosis_up hsa-mir-21 Esophageal Neoplasms 23224754 Clinical impact of serum exosomal microRNA-21 as a clinical biomarker in human esophageal squamous cell carcinoma -circulation_biomarker_diagnosis_up hsa-mir-132 Inflammation 23264652 "In peptidoglycan (PGN)/TLR2-stimulated THP-1 monocytes, PBMCs, and primary macrophages showed rapid and dramatic miR-132 and miR-212 (miR-132/-212) upregulation." -circulation_biomarker_diagnosis_up hsa-mir-212 Inflammation 23264652 "In peptidoglycan (PGN)/TLR2-stimulated THP-1 monocytes, PBMCs, and primary macrophages showed rapid and dramatic miR-132 and miR-212 (miR-132/-212) upregulation." -circulation_biomarker_diagnosis_up hsa-mir-200a Ovarian Neoplasms 23272653 Elevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancer -circulation_biomarker_diagnosis_up hsa-mir-200b Ovarian Neoplasms 23272653 Elevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancer -circulation_biomarker_diagnosis_up hsa-mir-200c Ovarian Neoplasms 23272653 Elevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancer -circulation_biomarker_diagnosis_up hsa-mir-15b Fatty Liver [unspecific] 23287814 Upregulation of miR-15b in NAFLD models and in the serum of patients with fatty liver disease -circulation_biomarker_diagnosis_up hsa-mir-145 Hypertension 23339529 Overexpression of microRNA-145 in atherosclerotic plaques from hypertensive patients -circulation_biomarker_diagnosis_up hsa-mir-155 Breast Neoplasms 23372341 serum;miR-205 was down-regulated and miR-155 was up-regulated in BC patient serum -circulation_biomarker_diagnosis_up hsa-mir-205 Breast Neoplasms 23372341 serum;miR-205 was down-regulated and miR-155 was up-regulated in BC patient serum -circulation_biomarker_diagnosis_up hsa-mir-141 Prostate Neoplasms 23377530 serum;An elevated serum miR-141 level in patients with bone-metastatic prostate cancer is correlated with more bone lesions -circulation_biomarker_diagnosis_up hsa-mir-106b Heart Failure 23388090 "Quantitative real-time polymerase chain reaction (PCR) analysis for a selected panel of miRNAs indicated that circulating levels of miR-16, miR-20b, miR-93, miR-106b, miR-223, and miR-423-5p were significantly increased in response to hypertension-induced heart failure" -circulation_biomarker_diagnosis_up hsa-mir-16 Heart Failure 23388090 "Quantitative real-time polymerase chain reaction (PCR) analysis for a selected panel of miRNAs indicated that circulating levels of miR-16, miR-20b, miR-93, miR-106b, miR-223, and miR-423-5p were significantly increased in response to hypertension-induced heart failure" -circulation_biomarker_diagnosis_up hsa-mir-20b Heart Failure 23388090 "Quantitative real-time polymerase chain reaction (PCR) analysis for a selected panel of miRNAs indicated that circulating levels of miR-16, miR-20b, miR-93, miR-106b, miR-223, and miR-423-5p were significantly increased in response to hypertension-induced heart failure" -circulation_biomarker_diagnosis_up hsa-mir-223 Heart Failure 23388090 "Quantitative real-time polymerase chain reaction (PCR) analysis for a selected panel of miRNAs indicated that circulating levels of miR-16, miR-20b, miR-93, miR-106b, miR-223, and miR-423-5p were significantly increased in response to hypertension-induced heart failure" -circulation_biomarker_diagnosis_up hsa-mir-423 Heart Failure 23388090 "Quantitative real-time polymerase chain reaction (PCR) analysis for a selected panel of miRNAs indicated that circulating levels of miR-16, miR-20b, miR-93, miR-106b, miR-223, and miR-423-5p were significantly increased in response to hypertension-induced heart failure" -circulation_biomarker_diagnosis_up hsa-mir-93 Heart Failure 23388090 "Quantitative real-time polymerase chain reaction (PCR) analysis for a selected panel of miRNAs indicated that circulating levels of miR-16, miR-20b, miR-93, miR-106b, miR-223, and miR-423-5p were significantly increased in response to hypertension-induced heart failure" -circulation_biomarker_diagnosis_up hsa-mir-142 Systemic Lupus Erythematosus 23401079 "Seven miRNAs were statistically significantly differentially expressed in plasma from patients with SLE. The expression of miRNA-142-3p (miR-142-3p) and miR-181a was increased, and the expression of miR-106a, miR-17, miR-20a, miR-203,and miR-92a was decreased" -circulation_biomarker_diagnosis_up hsa-mir-181 Systemic Lupus Erythematosus 23401079 "Seven miRNAs were statistically significantly differentially expressed in plasma from patients with SLE. The expression of miRNA-142-3p (miR-142-3p) and miR-181a was increased, and the expression of miR-106a, miR-17, miR-20a, miR-203,and miR-92a was decreased" -circulation_biomarker_diagnosis_up hsa-mir-423-5p Heart Failure 23438607 Patients with DCM have elevated plasma miR-423-5p levels. The plasma concentration of miR-423-5p was positively correlated with the level of NT-proBNP. Circulating levels of miR-423-5p could be served as a diagnostic biomarker for heart failure caused by DCM. -circulation_biomarker_diagnosis_up hsa-mir-132 Hypertension 23712358 "The miR-132 and miR-212 are highly increased in the heart, aortic wall and kidney of rats with hypertension (159 ¡À 12 mm Hg) and cardiac hypertrophy following chronic AngII infusion." -circulation_biomarker_diagnosis_up hsa-mir-212 Hypertension 23712358 "The miR-132 and miR-212 are highly increased in the heart, aortic wall and kidney of rats with hypertension (159 ¡À 12 mm Hg) and cardiac hypertrophy following chronic AngII infusion." -circulation_biomarker_diagnosis_up hsa-mir-122 "Fatty Liver, Non-Alcoholic" 23727030 "Serum levels of miRNAs, miR-21, miR-34a, miR-122, and miR-451 were higher in participants with NAFLD. The serum level of miR-122 was correlated with the severity of liver steatosis." -circulation_biomarker_diagnosis_up hsa-mir-21 "Fatty Liver, Non-Alcoholic" 23727030 "Serum levels of miRNAs, miR-21, miR-34a, miR-122, and miR-451 were higher in participants with NAFLD. The serum level of miR-122 was correlated with the severity of liver steatosis." -circulation_biomarker_diagnosis_up hsa-mir-34a "Fatty Liver, Non-Alcoholic" 23727030 "Serum levels of miRNAs, miR-21, miR-34a, miR-122, and miR-451 were higher in participants with NAFLD. The serum level of miR-122 was correlated with the severity of liver steatosis." -circulation_biomarker_diagnosis_up hsa-mir-451 "Fatty Liver, Non-Alcoholic" 23727030 "Serum levels of miRNAs, miR-21, miR-34a, miR-122, and miR-451 were higher in participants with NAFLD. The serum level of miR-122 was correlated with the severity of liver steatosis." -circulation_biomarker_diagnosis_up hsa-mir-192 Heart Failure 23743335 "Among the 377 examined microRNAs, the serum level of only miR-192 was significantly upregulated in AMI patients with development of ischemic HF" -circulation_biomarker_diagnosis_up hsa-let-7d Alzheimer Disease 23895045 A blood based 12-miRNA signature of Alzheimer disease patients. -circulation_biomarker_diagnosis_up hsa-mir-112 Alzheimer Disease 23895045 A blood based 12-miRNA signature of Alzheimer disease patients. -circulation_biomarker_diagnosis_up hsa-mir-151a Alzheimer Disease 23895045 A blood based 12-miRNA signature of Alzheimer disease patients. -circulation_biomarker_diagnosis_up hsa-mir-161 Alzheimer Disease 23895045 A blood based 12-miRNA signature of Alzheimer disease patients. -circulation_biomarker_diagnosis_up hsa-mir-5010 Alzheimer Disease 23895045 A blood based 12-miRNA signature of Alzheimer disease patients. -circulation_biomarker_diagnosis_up hsa-mir-221 "Leukemia, Myeloid, Acute" 23895238 Overexpression of primary microRNA 221/222 in acute myeloid leukemia. -circulation_biomarker_diagnosis_up hsa-mir-222 "Leukemia, Myeloid, Acute" 23895238 Overexpression of primary microRNA 221/222 in acute myeloid leukemia. -circulation_biomarker_diagnosis_up hsa-mir-146a Breast Neoplasms 23898484 Overexpression of circulating miRNA-21 and miRNA-146a in plasma samples of breast cancer patients. -circulation_biomarker_diagnosis_up hsa-mir-21 Breast Neoplasms 23898484 Overexpression of circulating miRNA-21 and miRNA-146a in plasma samples of breast cancer patients. -circulation_biomarker_diagnosis_up hsa-mir-10b Choriocarcinoma 23933230 "we observed that miR-21 was significantly overexpressed in PDAC, and miR-10b was highly expressed in PanIN II-III." -circulation_biomarker_diagnosis_up hsa-mir-146a "Diabetes Mellitus, Type 2" 24023848 circulating miRNA-146a levels were significantly elevated in new-T2DM patients compared with healthy controls. Whether expression of circulating miRNA-146a holds predictive value for T2DM warrants further investigations. -circulation_biomarker_diagnosis_up hsa-mir-375 "Adenocarcinoma, Pancreatic Ductal" 24048453 "In the plasma-miRNA population, we find miRNA-375, which is selectively expressed in the endocrine pancreas under normal conditions, increased in PDAC cases compared with patients with other pancreatic or gastrointestinal diseases. The miRNA-375 does not outperform CA-19-9 diagnostically in the present cohort." -circulation_biomarker_diagnosis_up hsa-mir-202 Multiple Myeloma 24048721 "The relative expression of serum miR-202 in MM patients was significantly higher than that in healthy controls, and therefore it may prove to be useful in the auxiliary diagnosis of MM." -circulation_biomarker_diagnosis_up hsa-mir-146a Rheumatoid Arthritis 24120842 "Elevated expression of specific microRNAs (miRNA) in peripheral blood-derived mononuclear cells (PBMC), particularly miR-146a and miR-155, is associated with rheumatoid arthritis (RA)." -circulation_biomarker_diagnosis_up hsa-mir-155 Rheumatoid Arthritis 24120842 "Elevated expression of specific microRNAs (miRNA) in peripheral blood-derived mononuclear cells (PBMC), particularly miR-146a and miR-155, is associated with rheumatoid arthritis (RA)." -circulation_biomarker_diagnosis_up hsa-mir-369 Psoriasis 24135466 "The expression of miR-369-3p is increased in both serum samples and skin tissues from psoriasis patients, and its level in the skin positively correlates with disease severity. Further studies are needed to clarify the role of miR-369-3p in the pathogenesis of psoriasis." -circulation_biomarker_diagnosis_up hsa-mir-29a "Cardiomyopathy, Hypertrophic" 24161319 "cardiac remodeling associated with HCM determines a significant release of miRNAs into the bloodstream: the circulating levels of both cardiac- and non-cardiac-specific miRNAs are significantly increased in the plasma of HCM patients. However, correlation with left ventricular hypertrophy parameters holds true for only a few miRNAs (i.e.,miR-199a-5p, -27a, and -29a), whereas only miR-29a is significantly associated with both hypertrophy and fibrosis, identifying it as a potential biomarker for myocardial remodeling assessment in HCM." -circulation_biomarker_diagnosis_up hsa-mir-155 "Adenocarcinoma, Lung" 24190459 endogenous miR-155 stably existed in patient serum and could be sensitively and specifically measured. Overexpression of miR-155 in serum specimens could constitute a diagnostic marker for the early detection of lung adenocarcinoma. -circulation_biomarker_diagnosis_up hsa-mir-208a Acute Myocardial Infarction 24253456 Early in acute myocardial infarction the expression of miR-423-5p in plasma is significantly increased with subsequent normalization within 6 hours.Potentially it is an early marker of myocardial necrosis. -circulation_biomarker_diagnosis_up hsa-mir-423 Acute Myocardial Infarction 24253456 Early in acute myocardial infarction the expression of miR-423-5p in plasma is significantly increased with subsequent normalization within 6 hours.Potentially it is an early marker of myocardial necrosis. -circulation_biomarker_diagnosis_up hsa-mir-200c Kawasaki Syndrome 24259014 Elevated serum level of microRNA (miRNA)-200c and miRNA-371-5p in children with Kawasaki disease. -circulation_biomarker_diagnosis_up hsa-mir-371 Kawasaki Syndrome 24259014 Elevated serum level of microRNA (miRNA)-200c and miRNA-371-5p in children with Kawasaki disease. -circulation_biomarker_diagnosis_up hsa-mir-1 Essential Hypertension 24284386 "Hypertensive patients showed lower miR-143, miR-145 and miR-133 and higher miR-21 and miR-1 expression levels compared with controls" -circulation_biomarker_diagnosis_up hsa-mir-185 Idiopathic Short Stature 24342208 plasma miR-185 expression was significantly up-regulated -circulation_biomarker_diagnosis_up hsa-mir-208a Myocardial Infarction 24482699 Serum miR-208a was increased by 36-fold and 51-fold while miR-499 was elevated by 103-fold and 95-fold at 4 h and 24 h after AMI. -circulation_biomarker_diagnosis_up hsa-mir-499 Myocardial Infarction 24482699 Serum miR-208a was increased by 36-fold and 51-fold while miR-499 was elevated by 103-fold and 95-fold at 4 h and 24 h after AMI. -circulation_biomarker_diagnosis_up hsa-mir-22 Graves Disease 24533739 "Further analysis consistently showed that serum levels of miR-22, miR-375 and miR-451 were increased in patients with HT. On the other hand, the serum levels of miR-16, miR-22, miR-375 and miR-451 were increased in patients with GD compared with healthy subjects." -circulation_biomarker_diagnosis_up hsa-mir-192 Ischemia-Reperfusion Injury 24553149 "However, miR-10a, miR-192, and miR-194 were significantly increased in plasma of rats with renal ischemia-reperfusion injury, among which miR-10a was elevated within 1 h after reperfusion, whereas miR-192 and miR-194 were elevated at 6 h after injury." -circulation_biomarker_diagnosis_up hsa-mir-194 Ischemia-Reperfusion Injury 24553149 "However, miR-10a, miR-192, and miR-194 were significantly increased in plasma of rats with renal ischemia-reperfusion injury, among which miR-10a was elevated within 1 h after reperfusion, whereas miR-192 and miR-194 were elevated at 6 h after injury." -circulation_biomarker_diagnosis_up hsa-mir-21 Chronic Obstructive Pulmonary Disease 24556821 An increased ratio of serum miR-21 to miR-181a levels is associated with the early pathogenic process of chronic obstructive pulmonary disease in asymptomatic heavy smokers. -circulation_biomarker_diagnosis_up hsa-mir-29a Ankylosing Spondylitis 24593209 "We report for the first time elevated miR-29a expression in PBMCs of patients with ankylosing spondylitis, and miR-29a might be used as a useful diagnostic marker in new bone formation but cannot reflect disease activity." -circulation_biomarker_diagnosis_up hsa-mir-204 Kidney Injury 24641951 Our findings indicate that miR-204/miR-211 downregulation accounts at least partially for the Hmx1 upregulation and the miR-204/miR-211-Hmx1 signaling axis may contribute to immune-suppression in the host thereby the Candidemia-induced kidney dysfunction. -circulation_biomarker_diagnosis_up hsa-mir-211 Kidney Injury 24641951 Our findings indicate that miR-204/miR-211 downregulation accounts at least partially for the Hmx1 upregulation and the miR-204/miR-211-Hmx1 signaling axis may contribute to immune-suppression in the host thereby the Candidemia-induced kidney dysfunction. -circulation_biomarker_diagnosis_up hsa-mir-100 "Squamous Cell Carcinoma, Esophageal" 24651474 "Seven serum miRNAs were found to be significantly higher in ESCC than in controls; namely, miR-25, miR-100, miR-193-3p, miR-194, miR-223, miR-337-5p and miR-483-5p" -circulation_biomarker_diagnosis_up hsa-mir-193 "Squamous Cell Carcinoma, Esophageal" 24651474 "Seven serum miRNAs were found to be significantly higher in ESCC than in controls; namely, miR-25, miR-100, miR-193-3p, miR-194, miR-223, miR-337-5p and miR-483-5p" -circulation_biomarker_diagnosis_up hsa-mir-194 "Squamous Cell Carcinoma, Esophageal" 24651474 "Seven serum miRNAs were found to be significantly higher in ESCC than in controls; namely, miR-25, miR-100, miR-193-3p, miR-194, miR-223, miR-337-5p and miR-483-5p" -circulation_biomarker_diagnosis_up hsa-mir-223 "Squamous Cell Carcinoma, Esophageal" 24651474 "Seven serum miRNAs were found to be significantly higher in ESCC than in controls; namely, miR-25, miR-100, miR-193-3p, miR-194, miR-223, miR-337-5p and miR-483-5p" -circulation_biomarker_diagnosis_up hsa-mir-25 "Squamous Cell Carcinoma, Esophageal" 24651474 "Seven serum miRNAs were found to be significantly higher in ESCC than in controls; namely, miR-25, miR-100, miR-193-3p, miR-194, miR-223, miR-337-5p and miR-483-5p" -circulation_biomarker_diagnosis_up hsa-mir-337 "Squamous Cell Carcinoma, Esophageal" 24651474 "Seven serum miRNAs were found to be significantly higher in ESCC than in controls; namely, miR-25, miR-100, miR-193-3p, miR-194, miR-223, miR-337-5p and miR-483-5p" -circulation_biomarker_diagnosis_up hsa-mir-483 "Squamous Cell Carcinoma, Esophageal" 24651474 "Seven serum miRNAs were found to be significantly higher in ESCC than in controls; namely, miR-25, miR-100, miR-193-3p, miR-194, miR-223, miR-337-5p and miR-483-5p" -circulation_biomarker_diagnosis_up hsa-mir-21 Systemic Lupus Erythematosus 24659142 "Plasma miR-21 in SLE patients from Central China is overexpressed.Since circulating miR-21 is aberrantly expressed in many diseases, the applying of it as a disease biomarker should be considered carefully." -circulation_biomarker_diagnosis_up hsa-mir-146a Sepsis 24680405 "The expression levels of miR-146a and miR-223 in plasma in pediatric patients with sepsis was significantly upregulated, and had a positive correlation with IL-10 and IL-10/TNF-¦Á, which may be used as early diagnostic markers and can reflect the severity of condition to a certain degree." -circulation_biomarker_diagnosis_up hsa-mir-223 Sepsis 24680405 "The expression levels of miR-146a and miR-223 in plasma in pediatric patients with sepsis was significantly upregulated, and had a positive correlation with IL-10 and IL-10/TNF-¦Á, which may be used as early diagnostic markers and can reflect the severity of condition to a certain degree." -circulation_biomarker_diagnosis_up hsa-mir-516a "Systemic Lupus Erythematosus, With Pericarditis" 24687380 "High expression levels of microRNA-629, microRNA-525-5p and microRNA-516a-3p in paediatric systemic lupus erythematosus." -circulation_biomarker_diagnosis_up hsa-mir-525 "Systemic Lupus Erythematosus, With Pericarditis" 24687380 "High expression levels of microRNA-629, microRNA-525-5p and microRNA-516a-3p in paediatric systemic lupus erythematosus." -circulation_biomarker_diagnosis_up hsa-mir-629 "Systemic Lupus Erythematosus, With Pericarditis" 24687380 "High expression levels of microRNA-629, microRNA-525-5p and microRNA-516a-3p in paediatric systemic lupus erythematosus." -circulation_biomarker_diagnosis_up hsa-mir-193b Pancreatic Endocrine Carcinoma 24778027 "Evaluation of microRNAs appears to be promising in the assessment of pNEN. In particular, miR-193b, which is also increased in serum, may be a potential new biomarker of pNEN." -circulation_biomarker_diagnosis_up hsa-mir-21 Ankylosing Spondylitis 24786924 Higher expression of whole blood microRNA-21 in patients with ankylosing spondylitis associated with programmed cell death 4 mRNA expression and collagen cross-linked C-telopeptide concentration. -circulation_biomarker_diagnosis_up hsa-mir-21 Atherosclerosis 24848278 "In atherosclerosis, miR-21, 122, 130a, and 211 were significantly increased whereas miR-92a, 126, and 222 were markedly decreased." -circulation_biomarker_diagnosis_up hsa-mir-143 "Diabetes Mellitus, Type 2" 24927876 Elevated expression levels of miR-143/5 in saphenous vein smooth muscle cells from patients with Type 2 diabetes drive persistent changes in phenotype and function. -circulation_biomarker_diagnosis_up hsa-mir-145 "Diabetes Mellitus, Type 2" 24927876 Elevated expression levels of miR-143/5 in saphenous vein smooth muscle cells from patients with Type 2 diabetes drive persistent changes in phenotype and function. -circulation_biomarker_diagnosis_up hsa-mir-146a Sjogren Syndrome 24931100 "Our results demonstrated miR-146a overexpression and miR-155 underexpression in the peripheral mononuclear blood cells of the patients with pSS. Furthermore, the expression levels of these miRNAs correlated with the patients' clinical features. Our data suggest that miR-146a and miR-155 might play important roles in the pathogenesis of pSS and that their expression levels may be useful for diagnosing pSS and for predicting disease activity and therapeutic responses." -circulation_biomarker_diagnosis_up hsa-mir-196a Pancreatic Neoplasms 24956938 Serum levels of miR-196a and -196b were significantly higher in mice with PanIN2/3 lesions (n = 10) or PC (n = 8) as compared to control mice (n = 10) or mice with PanIN1 lesions (n = 10; P = .01). -circulation_biomarker_diagnosis_up hsa-mir-130a Moyamoya Disease 25093848 "In an independent MMD cohort, real-time PCR confirmed that miR-106b, miR-130a and miR-126 were significantly upregulated while miR-125a-3p was significantly downregulated in serum." -circulation_biomarker_diagnosis_up hsa-mir-21 Neoplasms [unspecific] 25098165 "Over-expression of mir-21, especially in cancerous tissue, was effectively predictive of worse prognosis in various carcinomas. Non-invasive circulating mir-21, however, exhibited modest ability to discriminate outcomes.Major concerns about mir-21 assay standardization and selection of specimen need to be fully addressed before its practical implementation in management of cancer." -circulation_biomarker_diagnosis_up hsa-mir-323 Acute Coronary Syndrome 25124998 Our study identifies miR-652 as a novel candidate biomarker for post-ACS prognosis beyond existing biomarkers of LVEF and NT-proBNP. Moreover circulating miR-323-3p was markedly elevated in patients for at least a year post-ACS and may be a stable biomarker for ACS. -circulation_biomarker_diagnosis_up hsa-mir-652 Acute Coronary Syndrome 25124998 Our study identifies miR-652 as a novel candidate biomarker for post-ACS prognosis beyond existing biomarkers of LVEF and NT-proBNP. Moreover circulating miR-323-3p was markedly elevated in patients for at least a year post-ACS and may be a stable biomarker for ACS. -circulation_biomarker_diagnosis_up hsa-mir-181a Sjogren Syndrome 25128511 "Together, these observations suggested that an elevated miRNA-181a level is a general phenomenon in Chinese patients with pSS." -circulation_biomarker_diagnosis_up hsa-mir-338 Amyotrophic Lateral Sclerosis 25130371 "miR-338-3p is over-expressed in blood, CFS, serum and spinal cord from sporadic amyotrophic lateral sclerosis patients." -circulation_biomarker_diagnosis_up hsa-mir-21 Colorectal Carcinoma 25178939 Elevated level of microRNA-21 in the serum of patients with colorectal cancer. -circulation_biomarker_diagnosis_up hsa-mir-1 Myocardial Infarction 25225581 the expression of plasma miR-1 was significantly increased in the AMI patients compared with the healthy controls -circulation_biomarker_diagnosis_up hsa-mir-92a "Lymphoma, Non-Hodgkin" 25236768 "MiR-92a was decreased exclusively in HBV-/HCV- B-NHLs, while miR-30b was increased in HBV+ and HCV+ samples, though only the HCV+ achieved full statistical significance." -circulation_biomarker_diagnosis_up hsa-mir-205 Pancreatic Neoplasms 25258651 "A marked difference in the profiles of four circulating miRNAs (miR-205, miR-210, miR-492, and miR-1427) was observed in pancreatic juice collected from patients with PDAC and those without pancreatic disease." -circulation_biomarker_diagnosis_up hsa-mir-210 Pancreatic Neoplasms 25258651 "A marked difference in the profiles of four circulating miRNAs (miR-205, miR-210, miR-492, and miR-1427) was observed in pancreatic juice collected from patients with PDAC and those without pancreatic disease." -circulation_biomarker_diagnosis_up hsa-mir-373 Breast Neoplasms 25333260 Increased serum levels of circulating exosomal microRNA-373 in receptor-negative breast cancer patients. -circulation_biomarker_diagnosis_up hsa-mir-195 Heart Failure 25364765 "Circulating miR-195 is elevated in acute myocardial infarction, breast cancer, prostate cancer and colorectal adenoma." -circulation_biomarker_diagnosis_up hsa-mir-21 Pancreatic Neoplasms 25384963 Circulating miR-483-3p and miR-21 is highly expressed in plasma of pancreatic cancer. -circulation_biomarker_diagnosis_up hsa-mir-483 Pancreatic Neoplasms 25384963 Circulating miR-483-3p and miR-21 is highly expressed in plasma of pancreatic cancer. -circulation_biomarker_diagnosis_up hsa-mir-221 Hepatitis C Virus Infection 25433287 HCVcc infection could upregulate the expression of miR-221 in NF-¦ÊB dependent manner. -circulation_biomarker_diagnosis_up hsa-mir-122 Chronic Hepatitis C 25461662 "serum microRNA-122 was elevated in acute and chronic hepatitis patients. However, this biomarker for acute liver injury did not reflect the liver inflammation activity in CHC patients." -circulation_biomarker_diagnosis_up hsa-mir-421 Gastric Neoplasms 25510566 miR-421 increased significantly in GC patients than in controls. miR-421 in either serum or PBMCs had higher sensitivity and specificity than CEA and CA-125 in GC diagnosis. -circulation_biomarker_diagnosis_up hsa-mir-203 Atopic Dermatitis 25531302 miR-203 and miR-483-5p were significantly up-regulated in serum of children with AD compared with healthy children. -circulation_biomarker_diagnosis_up hsa-mir-132 Mild Cognitive Impairment 25589731 circulating miR-206 and miR-132 as novel miRNAs upregulated in MCI patient were potential biomarkers for diagnosis of MCI. -circulation_biomarker_diagnosis_up hsa-mir-206 Mild Cognitive Impairment 25589731 circulating miR-206 and miR-132 as novel miRNAs upregulated in MCI patient were potential biomarkers for diagnosis of MCI. -circulation_biomarker_diagnosis_up hsa-mir-133 Arrhythmia 25625292 patients with SVT had lower miR-1 expression levels while those with VT had higher miR-133 expression levels. -circulation_biomarker_diagnosis_up hsa-mir-182 Heart Failure 25643195 "Microarray profiling revealed an increase in the expression of miR-21, miR-650, miR-744, miR-516-5p, miR-1292, miR-182, miR-1228, miR-595, miR-663b, miR-1296, miR-1825, miR-299-3p, miR-662 miR-122, miR-3148 and miR-518e and a decrease in the expression of miR-129-3p, miR-3155, miR-3175, miR-583, miR-568, miR-30d, miR-200a-star, miR-1979, miR-371-3p, miR-155-star and miR-502-5p in sera of CHF patients." -circulation_biomarker_diagnosis_up hsa-mir-299 Heart Failure 25643195 "Microarray profiling revealed an increase in the expression of miR-21, miR-650, miR-744, miR-516-5p, miR-1292, miR-182, miR-1228, miR-595, miR-663b, miR-1296, miR-1825, miR-299-3p, miR-662 miR-122, miR-3148 and miR-518e and a decrease in the expression of miR-129-3p, miR-3155, miR-3175, miR-583, miR-568, miR-30d, miR-200a-star, miR-1979, miR-371-3p, miR-155-star and miR-502-5p in sera of CHF patients." -circulation_biomarker_diagnosis_up hsa-mir-197 Breast Neoplasms 25644077 "The expression level of miR-29b-2, -155, -197 and -205 was significantly increased in the serum of breast cancer patients." -circulation_biomarker_diagnosis_up hsa-mir-10a "Leukemia, Myeloid, Acute" 25687041 "The high expression of miR-10a may be closely related to over-proliferation of promyelocyte and drug resistance of acute myeloid leukemia cells, except M3." -circulation_biomarker_diagnosis_up hsa-mir-126 Atherosclerosis 25697638 and the levels of miR-126 had positive correlation with cerebral atherosclerosis -circulation_biomarker_diagnosis_up hsa-mir-17 Atherosclerosis 25697638 he levels of miR-17 were significantly increased in acute stroke patients -circulation_biomarker_diagnosis_up hsa-mir-101 "Diabetes Mellitus, Type 2" 25726255 "The present findings demonstrated that the circulating miR-101, miR-375 and miR-802 levels are significantly increased in T2D patients versus NGT subjects and they may become the new biomarkers for type 2 diabetes." -circulation_biomarker_diagnosis_up hsa-mir-375 "Diabetes Mellitus, Type 2" 25726255 "The present findings demonstrated that the circulating miR-101, miR-375 and miR-802 levels are significantly increased in T2D patients versus NGT subjects and they may become the new biomarkers for type 2 diabetes." -circulation_biomarker_diagnosis_up hsa-mir-802 "Diabetes Mellitus, Type 2" 25726255 "The present findings demonstrated that the circulating miR-101, miR-375 and miR-802 levels are significantly increased in T2D patients versus NGT subjects and they may become the new biomarkers for type 2 diabetes." -circulation_biomarker_diagnosis_up hsa-mir-29a Colorectal Carcinoma 25736690 Significant upregulation of miR-29a in CRC was reported when compared to normal -circulation_biomarker_diagnosis_up hsa-mir-146a Oral Lichen Planus 25779071 The expressions of PBMC and plasma miRNA-155 and miRNA-146a are higher in OLP patients. The expressions of plasma miRNA-155 and miRNA-146a are associated with OLP severity. The over expression of miRNA-155 and miRNA-146a in OLP may play a role in the pathogenesis of OLP. -circulation_biomarker_diagnosis_up hsa-mir-155 Oral Lichen Planus 25779071 The expressions of PBMC and plasma miRNA-155 and miRNA-146a are higher in OLP patients. The expressions of plasma miRNA-155 and miRNA-146a are associated with OLP severity. The over expression of miRNA-155 and miRNA-146a in OLP may play a role in the pathogenesis of OLP. -circulation_biomarker_diagnosis_up hsa-mir-184 Oral Neoplasms 25784212 There was a highly significant increase in salivary miRNA-21 and miRNA-184 in OSCC and PMD -circulation_biomarker_diagnosis_up hsa-mir-296 Chronic Hepatitis C 25790297 "Serum miR-34a, miR-130a, miR-19a, miR-192, miR-195, and miR-296 were upregulated, whereas serum miR-146a was downregulated in CHC compared to controls." -circulation_biomarker_diagnosis_up hsa-mir-122 Hypertension 25837765 MiR-122 and miR-637 expressions were also significantly upregulated in the WCH group compared with the NT group -circulation_biomarker_diagnosis_up hsa-mir-10b "Carcinoma, Lung, Non-Small-Cell" 25869877 Prognostic value of microRNA-10b overexpression in peripheral blood mononuclear cells of nonsmall-cell lung cancer patients. -circulation_biomarker_diagnosis_up hsa-mir-192 Pancreatic Neoplasms 25894267 "Our data shows that miR-21, miR-192 and miR-200 could be used as new diagnostic markers for pancreatic cancer." -circulation_biomarker_diagnosis_up hsa-mir-200 Pancreatic Neoplasms 25894267 "Our data shows that miR-21, miR-192 and miR-200 could be used as new diagnostic markers for pancreatic cancer." -circulation_biomarker_diagnosis_up hsa-mir-21 Pancreatic Neoplasms 25894267 "Our data shows that miR-21, miR-192 and miR-200 could be used as new diagnostic markers for pancreatic cancer." -circulation_biomarker_diagnosis_up hsa-mir-182 "Carcinoma, Hepatocellular" 25903466 "our present study indicates that serum miR-182 and miR-331-3p, upregulated in HCC, can provide positive diagnostic and prognostic values for HCC" -circulation_biomarker_diagnosis_up hsa-mir-331 "Carcinoma, Hepatocellular" 25903466 Serum miR-182 and miR-331-3p as diagnostic and prognostic markers in patients with hepatocellular carcinoma. -circulation_biomarker_diagnosis_up hsa-mir-499 Myocardial Infarction 25922707 miR-499 was shown to substantially increase the diagnostic accuracy of CK-MB and cTnI in the diagnosis of AMI -circulation_biomarker_diagnosis_up hsa-mir-451 Mountain Sickness 25948209 "There is a certain level of microRNA-451 in healthy people, the expression of microRNA-451 in CMS patients is significantly higher than that in healthy people. MicroRNA-451 may play an important role in the process of chronic mountain sickness." -circulation_biomarker_diagnosis_up hsa-mir-499 Myocardial Infarction 25966174 the expression of microRNA-499 in serum of patients with AMI was significantly higher than in controls -circulation_biomarker_diagnosis_up hsa-mir-25 Pancreatic Neoplasms 25991015 "A combination of six serum miRNAs (miR-483-5p, miR-19a, miR-29a, miR-20a, miR-24, miR-25) was selected by qRT-PCR as a biomarker for PaC-DM." -circulation_biomarker_diagnosis_up hsa-mir-499 Acute Myocardial Infarction 26101645 miR-499 expression levels were significantly higher in the 53 AMI patients -circulation_biomarker_diagnosis_up hsa-mir-122 Hepatitis C Virus Infection 26157120 "During acute HCV infection, increases in miR-122 (P < 0.01) and miR-885-5p (Pcorrected < 0.05) and a decrease in miR-494 (Pcorrected < 0.05) were observed at the earliest time points after virus detection." -circulation_biomarker_diagnosis_up hsa-mir-223 Rheumatoid Arthritis 26164649 "MiR-16, miR-146a/b, miR-150, miR-155, and miR-223 described here were shown to be overexpressed at the systemic level: in both the periphery and RA joints." -circulation_biomarker_diagnosis_up hsa-mir-200a Cervical Neoplasms 26171195 The Solexa sequencing results revealed 12 markedly upregulated serum miRNAs in cervical cancer patients compared with controls -circulation_biomarker_diagnosis_up hsa-mir-146b Schizophrenia 26173148 "a nominally significant increase in the expression of several miRNAs was found in the 22q11.2 neurons that were previously found to be differentially expressed in autopsy samples and peripheral blood in SZ and autism spectrum disorders (e.g.,miR-34, miR-4449, miR-146b-3p, and miR-23a-5p)." -circulation_biomarker_diagnosis_up hsa-mir-23a Schizophrenia 26173148 "a nominally significant increase in the expression of several miRNAs was found in the 22q11.2 neurons that were previously found to be differentially expressed in autopsy samples and peripheral blood in SZ and autism spectrum disorders (e.g.,miR-34, miR-4449, miR-146b-3p, and miR-23a-5p)." -circulation_biomarker_diagnosis_up hsa-mir-34 Schizophrenia 26173148 "a nominally significant increase in the expression of several miRNAs was found in the 22q11.2 neurons that were previously found to be differentially expressed in autopsy samples and peripheral blood in SZ and autism spectrum disorders (e.g.,miR-34, miR-4449, miR-146b-3p, and miR-23a-5p)." -circulation_biomarker_diagnosis_up hsa-mir-4449 Schizophrenia 26173148 "a nominally significant increase in the expression of several miRNAs was found in the 22q11.2 neurons that were previously found to be differentially expressed in autopsy samples and peripheral blood in SZ and autism spectrum disorders (e.g.,miR-34, miR-4449, miR-146b-3p, and miR-23a-5p)." -circulation_biomarker_diagnosis_up hsa-mir-144 "Stroke, Ischemic" 26175178 "In conclusion, hyperglycemia may activate platelets through miR-144 and miR-223 to downregulate IRS-1 and upregulate P2Y12 expression in the platelets of T2DM patients through an IRS-1-PI3K-Akt signaling." -circulation_biomarker_diagnosis_up hsa-mir-223 "Stroke, Ischemic" 26175178 "In conclusion, hyperglycemia may activate platelets through miR-144 and miR-223 to downregulate IRS-1 and upregulate P2Y12 expression in the platelets of T2DM patients through an IRS-1-PI3K-Akt signaling." -circulation_biomarker_diagnosis_up hsa-mir-130b Schizophrenia 26183697 "The up-regulation of miR-130b and miR-193a-3p is a state-independent biomarker for schizophrenia, and these two miRNAs could be used to develop a diagnostic tool for schizophrenia." -circulation_biomarker_diagnosis_up hsa-mir-193a Schizophrenia 26183697 "The up-regulation of miR-130b and miR-193a-3p is a state-independent biomarker for schizophrenia, and these two miRNAs could be used to develop a diagnostic tool for schizophrenia." -circulation_biomarker_diagnosis_up hsa-mir-92a-2 Cardiac Allograft Vasculopathy 26198441 "Median plasma levels of miR-210-5p, miR-92a-3p, miR-126-3p, and miR-126-5p were higher in patients with CAV than in patients without CAV." -circulation_biomarker_diagnosis_up hsa-mir-133b Myocardial Infarction 26198874 "The level of miR-133a, miR-133b and miR-499-5p were significantly higher in both STEMI and NSTEMI patients compared to healthy volunteers" -circulation_biomarker_diagnosis_up hsa-mir-16 "Squamous Cell Carcinoma, Esophageal" 26221263 "Levels of four of the selected miRNAs were found to be significantly higher in ESCC patients than in controls; namely, miR-16, miR-21, miR-185, and miR-375 (P < 0.050)." -circulation_biomarker_diagnosis_up hsa-mir-370 Obesity 26223376 "circulating miR-27 (Pâ€?â€?.032), miR-378 (Pâ€?â€?.001) and miR-370 (Pâ€?â€?.045) in obese children were significantly higher" -circulation_biomarker_diagnosis_up hsa-mir-378 Obesity 26223376 "circulating miR-27 (Pâ€?â€?.032), miR-378 (Pâ€?â€?.001) and miR-370 (Pâ€?â€?.045) in obese children were significantly higher" -circulation_biomarker_diagnosis_up hsa-mir-33a Hypercholesterolaemia 26229086 Circulating miR-33a and miR-33b are up-regulated in familial hypercholesterolaemia in paediatric age. -circulation_biomarker_diagnosis_up hsa-mir-33b Hypercholesterolaemia 26229086 Circulating miR-33a and miR-33b are up-regulated in familial hypercholesterolaemia in paediatric age. -circulation_biomarker_diagnosis_up hsa-mir-21 Coronary Artery Disease 26248417 "miRNA-21 was significantly elevated in acute myocardial infarction subgroup than the control group. The level of miRNA-21 associates with the degree of coronary artery stenosis, and might be a potential marker for the diagnosis of acute myocardial infarction. miRNA-21 may play an important role in protecting myocardium from ischemia/reperfusion injury." -circulation_biomarker_diagnosis_up hsa-mir-223 Tuberculosis 26316141 "Leukocyte recruitment, measured as the expression of microRNA-223 was increased in pulmonary TB patients compared to LTBI" -circulation_biomarker_diagnosis_up hsa-mir-301a Autoimmune Diseases [unspecific] 26338824 Our data reveal a novel mechanism in which the elevated miR-301a in PBMC and inflamed mucosa of IBD promotes Th17 cell differentiation through downregulation of SNIP1. -circulation_biomarker_diagnosis_up hsa-mir-222 "Carcinoma, Hepatocellular" 26380927 "The serum levels of exosomal miR-18a, miR-221, miR-222 and miR-224 were significantly higher in patients with HCC" -circulation_biomarker_diagnosis_up hsa-mir-27b Diabetic Retinopathy 26395742 "miR-27b and miR-320a, were associated with incidence and with progression of retinopathy" -circulation_biomarker_diagnosis_up hsa-mir-107 Gastric Neoplasms 26406411 The overexpression of miR-107 in tumors and serum of gastric cancer patients and its correlation with HIF-1¦Á expression in tumor tissues was indicated that miR-107 may have a potential to use as a biomarker for detection of gastric cancer patients and hypoxia in gastric cancer tumor. -circulation_biomarker_diagnosis_up hsa-mir-191 Osteosarcoma 26406942 "Our data provide new insights for the involvement of miR-191 in osteosarcoma and suggest that the increased expression of miR-191 may be associated with aggressive tumor progression and adverse outcome. Of note, serum miR-191 quantification may be a promising biomarker for the diagnosis and prognosis in osteosarcoma." -circulation_biomarker_diagnosis_up hsa-mir-200b "Carcinoma, Ovarian" 26416421 Plasma miR-200b proved to have a greater average concentration in OvCa samples -circulation_biomarker_diagnosis_up hsa-mir-15a "Leukemia, Lymphoblastic, Acute" 26434860 "The results of our study indicate that resveratrol induces apoptosis in a time and dose-dependent manner in CCRF-CEM cells. Also, increased expression level of miR 16-1 and miR 15a by means of resveratrol in CCRF-CEM" -circulation_biomarker_diagnosis_up hsa-mir-16-1 "Leukemia, Lymphoblastic, Acute" 26434860 "The results of our study indicate that resveratrol induces apoptosis in a time and dose- dependent manner in CCRF-CEM cells. Also, increased expression level of miR 16-1 and miR 15a by means of resveratrol in CCRF-CEM" -circulation_biomarker_diagnosis_up hsa-mir-192 Cholangiocarcinoma 26456596 "We found that miR-192 was significantly higher in O. viverrini infected, PDF and also CCA groups (p<0.05) than in healthy controls." -circulation_biomarker_diagnosis_up hsa-mir-21 Cholangiocarcinoma 26456596 MiR-21 was significantly higher in PDF and CCA groups (p<0.05) than in healthy controls. -circulation_biomarker_diagnosis_up hsa-mir-18a "Leukemia, Myeloid, Chronic" 26458312 "up-regulated expression of oncogenic miRNAs (miR-17, miR-18a, miR-20a, miR-21, miR-27a and miR-155)" -circulation_biomarker_diagnosis_up hsa-mir-184 Neoplasms [unspecific] 26525105 "The increase of plasma miR-146a, miR-184 and miR-372 was detectable early in the induction, and it was particularly eminent at the most advanced lesion state." -circulation_biomarker_diagnosis_up hsa-mir-31 Neoplasms [unspecific] 26525105 "A progressive increase of miR-21, miR-31 and miR-146a in both saliva and plasma samples was also noted." -circulation_biomarker_diagnosis_up hsa-mir-372 Neoplasms [unspecific] 26525105 "The increase of plasma miR-146a, miR-184 and miR-372 was detectable early in the induction" -circulation_biomarker_diagnosis_up hsa-mir-208a Myocardial Infarction 26528525 miRNA-208a was increased in STEMI patients at the time of admission and nearly undetectable in CAD patients and controls. -circulation_biomarker_diagnosis_up hsa-mir-210 "Leukemia, Myeloid, Acute" 26549593 MiR-210 up-regulation was associated with poor prognosis in AML and it might be useful as a marker for predicting the clinical outcome of AML patients. -circulation_biomarker_diagnosis_up hsa-mir-423 Cardiovascular Diseases [unspecific] 26562412 "Our results suggested that miR-423-5p is enriched in PF, and serum miR-423-5p may be associate with uAP. Its expression pattern was different to that of muscle- and vascular-enriched miRNAs, miR-133a, miR-126, and miR-92a." -circulation_biomarker_diagnosis_up hsa-mir-223 Polycystic Ovarian Syndrome 26582398 "In conclusion, circulating miRNA-93 and miRNA-223 were higher in women with PCOS compared to age and weight matched controls independent of insulin resistance and testosterone levels, and miR-93 may represent a novel diagnostic biomarker for PCOS." -circulation_biomarker_diagnosis_up hsa-mir-93 Polycystic Ovarian Syndrome 26582398 "In conclusion, circulating miRNA-93 and miRNA-223 were higher in women with PCOS compared to age and weight matched controls independent of insulin resistance and testosterone levels, and miR-93 may represent a novel diagnostic biomarker for PCOS." -circulation_biomarker_diagnosis_up hsa-mir-208 Cardiomegaly 26622415 miR-208 expression levels are increased in the peripheral blood of patients with cardiac hypertrophy. -circulation_biomarker_diagnosis_up hsa-mir-195 Parkinson Disease 26631952 "miR-195 was up-regulated, and miR-185, miR-15b, miR-221 and miR-181a were down-regulated." -circulation_biomarker_diagnosis_up hsa-mir-206 Coronary Artery Disease 26685009 miRNA 206 and miRNA 574-5p are highly expression in coronary artery disease. -circulation_biomarker_diagnosis_up hsa-mir-574 Coronary Artery Disease 26685009 miRNA 206 and miRNA 574-5p are highly expression in coronary artery disease. -circulation_biomarker_diagnosis_up hsa-mir-196b "Leukemia, Myeloid, Acute" 26744876 The expression level of miR-155 was significantly higher in AML patients than in controls. -circulation_biomarker_diagnosis_up hsa-mir-191 Traumatic Brain Injury 26756543 "Elevated serum miR-93, miR-191, and miR-499 are noninvasive biomarkers for the presence and progression of traumatic brain injury." -circulation_biomarker_diagnosis_up hsa-mir-499 Traumatic Brain Injury 26756543 "Elevated serum miR-93, miR-191, and miR-499 are noninvasive biomarkers for the presence and progression of traumatic brain injury." -circulation_biomarker_diagnosis_up hsa-mir-93 Traumatic Brain Injury 26756543 "Elevated serum miR-93, miR-191, and miR-499 are noninvasive biomarkers for the presence and progression of traumatic brain injury." -circulation_biomarker_diagnosis_up hsa-mir-96 "Carcinoma, Hepatocellular" 26770453 Serum miR-96 levels in the HCC patients were remarkably higher than in the other groups -circulation_biomarker_diagnosis_up hsa-mir-92a Gastric Neoplasms 26790436 High expression of miR-92a compared with adjacent normal tissues was associated with shorter OS. -circulation_biomarker_diagnosis_up hsa-mir-125b Chronic Hepatitis B 26802212 serum miRNA-125b was positively correlated with the serum HBV DNA level. -circulation_biomarker_diagnosis_up hsa-mir-143 Pancreatic Adenocarcinoma 26807325 "Three miRNAs (miR-143, miR-223, and miR-30e) were significantly over-expressed in patients with Stage I cancer when compared with age-matched healthy individuals" -circulation_biomarker_diagnosis_up hsa-mir-223 Choriocarcinoma 26807325 "Three miRNAs (miR-143, miR-223, and miR-30e) were significantly over-expressed in patients with Stage I cancer when compared with age-matched healthy individuals" -circulation_biomarker_diagnosis_up hsa-mir-122 Chronic Hepatitis C 26812693 serum levels of miR-122 and miR-222 were significantly elevated in HCV patients -circulation_biomarker_diagnosis_up hsa-mir-222 Chronic Hepatitis C 26812693 the serum levels of miR-122 and miR-222 were significantly elevated in HCV patients -circulation_biomarker_diagnosis_up hsa-mir-21 Breast Neoplasms 26827795 the serum levels of miR-21 and miR-221 were significantly overexpressed in breast cancer patients -circulation_biomarker_diagnosis_up hsa-mir-221 Breast Neoplasms 26827795 the serum levels of miR-21 and miR-221 were significantly overexpressed in breast cancer patients -circulation_biomarker_diagnosis_up hsa-mir-885 Preeclampsia 26853698 "miR-885-5p is increased in plasma from pre-eclampsia compared with healthy pregnant women, and it is released into circulation mainly inside exosomes." -circulation_biomarker_diagnosis_up hsa-mir-122 Polycystic Ovarian Syndrome 26860517 "relative expression of miR-122, miR-193b, and miR-194 was up-regulated in PCOS patients" -circulation_biomarker_diagnosis_up hsa-mir-193b Polycystic Ovarian Syndrome 26860517 "relative expression of miR-122, miR-193b, and miR-194 was up-regulated in PCOS patients" -circulation_biomarker_diagnosis_up hsa-mir-194 Polycystic Ovarian Syndrome 26860517 "relative expression of miR-122, miR-193b, and miR-194 was up-regulated in PCOS patients" -circulation_biomarker_diagnosis_up hsa-mir-155 Lung Neoplasms 26867772 "Two miRNAs, miR-21 and miR-155, were found to be significantly upregulated in recurrent tumors compared to primary tumors." -circulation_biomarker_diagnosis_up hsa-mir-21 Lung Neoplasms 26867772 "Two miRNAs, miR-21 and miR-155, were found to be significantly upregulated in recurrent tumors compared to primary tumors." -circulation_biomarker_diagnosis_up hsa-mir-21 Multiple Myeloma 26909911 We found that the expression level of serum mir-21 in the MM group was significantly higher than the MGUS group and the NC group -circulation_biomarker_diagnosis_up hsa-let-7 Myasthenia Gravis 26943954 Disease specific enrichment of circulating let-7 family microRNA in MuSK+ myasthenia gravis. -circulation_biomarker_diagnosis_up hsa-mir-99b Chronic Fatigue Syndrome 26967895 "Microarray analysis identified differential expression of 34 miRNA, all of which were up-regulated." -circulation_biomarker_diagnosis_up hsa-mir-182 Glioma 26978735 Our findings showed that the level of circulating miR-182 in glioma patients was higher than that in healthy controls -circulation_biomarker_diagnosis_up hsa-mir-328 Atrial Fibrillation 26987792 Plasma levels of miR-328 were higher in patients with AF than in control subjects. -circulation_biomarker_diagnosis_up hsa-mir-96 Colorectal Adenocarcinoma 27044381 miR-96 is significantly upregulated in colorectal adenocarcinoma specimens compared to their non-cancerous counterparts -circulation_biomarker_diagnosis_up hsa-mir-15b Glioma 27047250 "we identified significantly increased levels of two candidate biomarkers, miR-15b and miR-21, in blood of patients affected by gliomas" -circulation_biomarker_diagnosis_up hsa-mir-16 Glioma 27047250 "we identified significantly increased levels of two candidate biomarkers, miR-15b and miR-21, in blood of patients affected by gliomas" -circulation_biomarker_diagnosis_up hsa-mir-21 Glioblastoma 27047250 "we identified significantly increased levels of two candidate biomarkers, miR-15b and miR-21, in blood of patients affected by gliomas" -circulation_biomarker_diagnosis_up hsa-mir-21 Glioma 27047250 "we identified significantly increased levels of two candidate biomarkers, miR-15b and miR-21, in blood of patients affected by gliomas" -circulation_biomarker_diagnosis_up hsa-mir-21 Autoimmune Lymphoproliferative Syndrome 27060458 "miR-21-3p was over-expressed significantly (P = 0·0313) in the son, with no significant change in the expression of miR-146a, miR-146a-3p and miR-21." -circulation_biomarker_diagnosis_up hsa-mir-21 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 27067271 "Compared with controls, miR-21 levels in tissue and plasma were significantly higher for both PLL and LSCC groups" -circulation_biomarker_diagnosis_up hsa-mir-124 Depression Disorder 27078210 expression levels of miR-124 from PBMCs in MDD patients were significantly higher than those in healthy controls -circulation_biomarker_diagnosis_up hsa-mir-133a Acute Myocardial Infarction 27124025 "circulating miR-133a is upregulated in AMI patients," -circulation_biomarker_diagnosis_up hsa-mir-135a Colorectal Carcinoma 27126269 Serum miR-135a-5p expression in colorectal cancer patients was higher than that in patients with colorectal polyps and healthy controls -circulation_biomarker_diagnosis_up hsa-mir-30c Aortic Stenosis 27129184 "Levels of miR-30c were higher in the AS group than in the controls (P<0.01), whereas levels of miR-106a, miR-148a, miR-204, miR-211, miR-31 and miR-424 were lower in the AS group than in the controls (P<0.01)." -circulation_biomarker_diagnosis_up hsa-mir-4449 Multiple Myeloma 27155004 The expression levels of serum miR-4449 in MM patients were significantly higher than in healthy controls -circulation_biomarker_diagnosis_up hsa-mir-499 Acute Myocardial Infarction 27162785 the circulating levels of miRNA-499 was increased in AMI patients. -circulation_biomarker_diagnosis_up hsa-mir-499 Heart Failure 27162785 the circulating levels of miRNA-499 was increased in AMI patients. -circulation_biomarker_diagnosis_up hsa-mir-21 Glioma 27166186 CSF-based miR-21 might serve as a potential biomarker for diagnosing brain cancer -circulation_biomarker_diagnosis_up hsa-mir-125b Myocardial Infarction 27176713 "miR-125b-5p and miR-30d-5p presented a diagnostic value for early diagnosis of AMI, and miRâ€?0dâ€?p may have a higher diagnostic value than cTnI." -circulation_biomarker_diagnosis_up hsa-mir-30d Acute Myocardial Infarction 27176713 "miR-125b-5p and miR-30d-5p presented a diagnostic value for early diagnosis of AMI, and miRâ€?0dâ€?p may have a higher diagnostic value than cTnI." -circulation_biomarker_diagnosis_up hsa-mir-146a Breast Neoplasms 27197674 "miR-21 (P < 0.001) and miR-146a (P = 0.001) were overexpressed, whereas miR-200c (P = 0.004) and miR-210 (P = 0.002) were underexpressed." -circulation_biomarker_diagnosis_up hsa-mir-21 Breast Neoplasms 27197674 "miR-21 (P < 0.001) and miR-146a (P = 0.001) were overexpressed, whereas miR-200c (P = 0.004) and miR-210 (P = 0.002) were underexpressed." -circulation_biomarker_diagnosis_up hsa-mir-125a Lupus Nephritis 27215082 "Elevated Serum Inflammatory Cytokines in Lupus Nephritis Patients, in Association with Promoted hsa-miR-125a." -circulation_biomarker_diagnosis_up hsa-mir-143 Sepsis 27225861 Serum miR-143 levels were significantly higher in patients with sepsis -circulation_biomarker_diagnosis_up hsa-mir-223 Viral Infectious Disease 27226534 vesicular stomatitis virus (VSV) infection induced significant up-regulation of miR-223 in murine macrophages. -circulation_biomarker_diagnosis_up hsa-mir-21 Stroke 27288814 The stroke with SAI group had significantly higher miRNA-21 expression -circulation_biomarker_diagnosis_up hsa-mir-16 Ischemia-Reperfusion Injury 27297958 urinary miR-16 was 100-fold higher in AKI patients. -circulation_biomarker_diagnosis_up hsa-mir-126 "Leukemia, B-Cell" 27300437 miRNA-126 is highly expressed in a subset of human B-ALL -circulation_biomarker_diagnosis_up hsa-mir-33b "Diabetes Mellitus, Type 2" 27301461 plasma miRNA33b may be useful as a new metabolic biomarker of dyslipidemia in patients with T2DM -circulation_biomarker_diagnosis_up hsa-let-7c Down Syndrome 27323694 "Seven miRNAs were verified as upregulated in DS placentas (miR-99a, miR-542-5p, miR-10b, miR-125b, miR-615, let-7c and miR-654)" -circulation_biomarker_diagnosis_up hsa-mir-199a Graft-Versus-Host Disease 27342518 "The expression of miR-423, miR-199a-3p, miR-93* are upregulated in aGVHD group, which can be used as biomarkes to monitor and to diagnose aGVHD." -circulation_biomarker_diagnosis_up hsa-mir-423 Graft-Versus-Host Disease 27342518 "The expression of miR-423, miR-199a-3p, miR-93* are upregulated in aGVHD group, which can be used as biomarkes to monitor and to diagnose aGVHD." -circulation_biomarker_diagnosis_up hsa-mir-93 Graft-Versus-Host Disease 27342518 "The expression of miR-423, miR-199a-3p, miR-93* are upregulated in aGVHD group, which can be used as biomarkes to monitor and to diagnose aGVHD." -circulation_biomarker_diagnosis_up hsa-mir-210 Myocardial Infarction 27346801 miRNA-499 and miRNA-210 expression levels were significantly increased -circulation_biomarker_diagnosis_up hsa-mir-499 Acute Coronary Syndrome 27346801 miRNA-499 and miRNA-210 expression levels were significantly increased -circulation_biomarker_diagnosis_up hsa-mir-499 Myocardial Infarction 27346801 miRNA-499 and miRNA-210 expression levels were significantly increased -circulation_biomarker_diagnosis_up hsa-mir-1266 Psoriasis 27371164 Increased MicroRNA-1266 levels as a biomarker for disease activity in psoriasis vulgaris. -circulation_biomarker_diagnosis_up hsa-mir-221 Acute Myocardial Infarction 27374153 Circulating miR-221-3p as a novel marker for early prediction of acute myocardial infarction. -circulation_biomarker_diagnosis_up hsa-mir-146b Acute Kidney Failure 27400799 "The results showed that in acute kidney injury induced by cisplatin, miR-146b in serum increased more quickly than did the usual indexes of kidney injury and decreased with restoration of MSCs." -circulation_biomarker_diagnosis_up hsa-mir-21 Prostate Neoplasms 27434290 The expression levels of miR-21 in PCa group were increased compared to BPH and control group -circulation_biomarker_diagnosis_up hsa-mir-133a Sepsis 27434558 The mRNA expressions of serum miR-155-5p and miR-133a-3p were gradually increased with the aggravation of sepsis. -circulation_biomarker_diagnosis_up hsa-mir-155 Sepsis 27434558 The mRNA expressions of serum miR-155-5p and miR-133a-3p were gradually increased with the aggravation of sepsis. -circulation_biomarker_diagnosis_up hsa-mir-223 Oral Neoplasms 27441818 "circulating miR-223 levels were significantly higher (~2-fold, P< 0.05) in patients with oral cancer (n = 31) than in those without cancer (n = 31)." -circulation_biomarker_diagnosis_up hsa-mir-30 Diabetic Nephropathy 27470555 "We found urinary exosomalmiR-133b, miR-342, and miR-30a were expressed at significantly elevated levels in T2DN patients (P<0.001) compared to normal." -circulation_biomarker_diagnosis_up hsa-mir-342 Diabetic Nephropathy 27470555 "We found urinary exosomalmiR-133b, miR-342, and miR-30a were expressed at significantly elevated levels in T2DN patients (P<0.001) compared to normal." -circulation_biomarker_diagnosis_up hsa-mir-122 Acute Pancreatitis 27477940 "In mice, we found that LPS-induced inflammation increases blood levels of MIR122, which reduces expression of Epo in the kidney;" -circulation_biomarker_diagnosis_up hsa-mir-22 Myocardial Infarction 27484208 Subsequent validation in an independent patient group confirmed that miRâ€?33b and miRâ€?2â€?p were significantly up‑regulated in the serum of patients with AMI. -circulation_biomarker_diagnosis_up hsa-mir-106b Schizophrenia 27489379 "Schizophrenia patients showed statistically significant upregulation of five microRNAs: miR9-5p (p=0.002), miR29a-3p (pï¼?.001), miR106b-5p (p=0.002), miR125a-3p (pï¼?.001), and miR125b-3p (p=0.018)." -circulation_biomarker_diagnosis_up hsa-mir-29a Schizophrenia 27489379 "Schizophrenia patients showed statistically significant upregulation of five microRNAs: miR9-5p (p=0.002), miR29a-3p (pï¼?.001), miR106b-5p (p=0.002), miR125a-3p (pï¼?.001), and miR125b-3p (p=0.018)." -circulation_biomarker_diagnosis_up hsa-mir-19a Allergic Rhinitis 27491928 "The results showed that the levels of miR-19a, but not the rest of the 5 members (miR-17, miR-18a, miR-19b, miR-20a, and miR-92a), were significantly higher in peripheral B cells from AR patients as than in B cells from healthy participants." -circulation_biomarker_diagnosis_up hsa-mir-146a Atherosclerosis 27502756 "In monocytes, miR124a and -125a were low, while miR-146a and miR-155 appeared elevated." -circulation_biomarker_diagnosis_up hsa-mir-21 Systemic Lupus Erythematosus 27510529 miR-21 was high expressed in SLE patients compared to their first-degree relatives and controls. -circulation_biomarker_diagnosis_up hsa-mir-147 Diabetes Mellitus 27518498 Analysis for serum microRNAs expression showed the distinctive and synergistic upregulation of miR-147 with periodontitis-induced effects in rats -circulation_biomarker_diagnosis_up hsa-mir-122 Acute Coronary Syndrome 27519051 "MiR-223, miR-92a, miR-486, miR-122, miR-125a and miR-146a levels were higher in the hyperglycemic ACS compared to normoglycemic sera." -circulation_biomarker_diagnosis_up hsa-mir-125a Acute Coronary Syndrome 27519051 "MiR-223, miR-92a, miR-486, miR-122, miR-125a and miR-146a levels were higher in the hyperglycemic ACS compared to normoglycemic sera." -circulation_biomarker_diagnosis_up hsa-mir-146a Acute Coronary Syndrome 27519051 "MiR-223, miR-92a, miR-486, miR-122, miR-125a and miR-146a levels were higher in the hyperglycemic ACS compared to normoglycemic sera." -circulation_biomarker_diagnosis_up hsa-mir-223 Acute Coronary Syndrome 27519051 "MiR-223, miR-92a, miR-486, miR-122, miR-125a and miR-146a levels were higher in the hyperglycemic ACS compared to normoglycemic sera." -circulation_biomarker_diagnosis_up hsa-mir-486 Acute Coronary Syndrome 27519051 "MiR-223, miR-92a, miR-486, miR-122, miR-125a and miR-146a levels were higher in the hyperglycemic ACS compared to normoglycemic sera." -circulation_biomarker_diagnosis_up hsa-mir-92a Acute Coronary Syndrome 27519051 "MiR-223, miR-92a, miR-486, miR-122, miR-125a and miR-146a levels were higher in the hyperglycemic ACS compared to normoglycemic sera." -circulation_biomarker_diagnosis_up hsa-mir-21 Kideny Transplant Rejection 27521993 our findings indicated that the aberrant urinary miR-21 and miR-200b expression levels were accompanied with renal allograft dysfunction and IFTA. -circulation_biomarker_diagnosis_up hsa-mir-217 "Diabetes Mellitus, Type 2" 27522360 "Compared with control, serum microRNA-217 levels were significantly increased in type 2 diabetes patients" -circulation_biomarker_diagnosis_up hsa-mir-146a Psoriasis 27535005 "Psoriasis patients presented, at baseline, increased expression of miRNA-155, let-7i, miRNA-146a, miRNA-21 and miRNA-223 in PBMCs, plus miRNA-21, miRNA-146a and miRNA-223 in plasma." -circulation_biomarker_diagnosis_up hsa-mir-155 Psoriasis 27535005 "Psoriasis patients presented, at baseline, increased expression of miRNA-155, let-7i, miRNA-146a, miRNA-21 and miRNA-223 in PBMCs, plus miRNA-21, miRNA-146a and miRNA-223 in plasma." -circulation_biomarker_diagnosis_up hsa-mir-21 Psoriasis 27535005 "Psoriasis patients presented, at baseline, increased expression of miRNA-155, let-7i, miRNA-146a, miRNA-21 and miRNA-223 in PBMCs, plus miRNA-21, miRNA-146a and miRNA-223 in plasma." -circulation_biomarker_diagnosis_up hsa-mir-223 Psoriasis 27535005 "Psoriasis patients presented, at baseline, increased expression of miRNA-155, let-7i, miRNA-146a, miRNA-21 and miRNA-223 in PBMCs, plus miRNA-21, miRNA-146a and miRNA-223 in plasma." -circulation_biomarker_diagnosis_up hsa-mir-181a "Lymphoma, B-Cell" 27535859 "The expression of hsa-miR-29a , hsa-miR-126 and has-miR-181 family were significantly different in B-ALL." -circulation_biomarker_diagnosis_up hsa-mir-181c "Leukemia, Lymphoblastic" 27535859 "The expression of hsa-miR-29a , hsa-miR-126 and has-miR-181 family were significantly different in B-ALL." -circulation_biomarker_diagnosis_up hsa-mir-155 Leukemia 27619068 MicroRNA-155 is upregulated in MLL-rearranged AML but its absence does not affect leukemia development. -circulation_biomarker_diagnosis_up hsa-mir-126 Arteriosclerosis Obliterans 27766047 "In smokers who completely attained smoking cessation, both RH-PAT index and plasma miR-126 values were increased" -circulation_biomarker_diagnosis_up hsa-mir-146a Melanoma 27895580 Increased Levels of miRNA-146a in Serum and Histologic Samples of Patients with Uveal Melanoma. -circulation_biomarker_diagnosis_up hsa-mir-127 "Carcinoma, Breast" 27983524 Combined detection of plasma miR-127-3p and HE4 improves the diagnostic efficacy of breast cancer. -circulation_biomarker_diagnosis_up hsa-mir-140 "Leukemia, Myeloid, Chronic" 28197964 Up-regulated exosomal miRNA-140-3p in CML patients with musculoskeletal pain associated with discontinuation of tyrosine kinase inhibitors. -circulation_biomarker_diagnosis_up hsa-mir-16 Hearing Loss 28224282 "The plasma levels of miR-24-3p, miR-16-5p,miR-185-5p, and miR-451a were upregulated during noise exposures, and increased levels of miR-21 have been found in vestibular schwannomas and human cholesteatoma" -circulation_biomarker_diagnosis_up hsa-mir-185 Hearing Loss 28224282 "The plasma levels of miR-24-3p, miR-16-5p,miR-185-5p, and miR-451a were upregulated during noise exposures, and increased levels of miR-21 have been found in vestibular schwannomas and human cholesteatoma" -circulation_biomarker_diagnosis_up hsa-mir-21 Cholesteatoma 28224282 "The plasma levels of miR-24-3p, miR-16-5p,miR-185-5p, and miR-451a were upregulated during noise exposures, and increased levels of miR-21 have been found in vestibular schwannomas and human cholesteatoma" -circulation_biomarker_diagnosis_up hsa-mir-21 Neurilemmoma 28224282 "The plasma levels of miR-24-3p, miR-16-5p,miR-185-5p, and miR-451a were upregulated during noise exposures, and increased levels of miR-21 have been found in vestibular schwannomas and human cholesteatoma" -circulation_biomarker_diagnosis_up hsa-mir-24 Hearing Loss 28224282 "The plasma levels of miR-24-3p, miR-16-5p,miR-185-5p, and miR-451a were upregulated during noise exposures, and increased levels of miR-21 have been found in vestibular schwannomas and human cholesteatoma" -circulation_biomarker_diagnosis_up hsa-mir-451a Hearing Loss 28224282 "The plasma levels of miR-24-3p, miR-16-5p,miR-185-5p, and miR-451a were upregulated during noise exposures, and increased levels of miR-21 have been found in vestibular schwannomas and human cholesteatoma" -circulation_biomarker_diagnosis_up hsa-mir-29a Atherosclerosis 28250354 Elevated Plasma miR-29a Levels Are Associated with Increased Carotid Intima-Media Thickness in Atherosclerosis Patients. -circulation_biomarker_diagnosis_up hsa-mir-155 Heart Failure 28319523 Plasma Levels of MicroRNA-155 Are Upregulated with Long-Term Left Ventricular Assist Device Support. -circulation_biomarker_diagnosis_up hsa-mir-142 Kideny Transplant Rejection 28380212 Upregulation of microRNA 142-3p in the peripheral blood and urinary cells of kidney transplant recipients with post-transplant graft dysfunction. -circulation_biomarker_diagnosis_up hsa-mir-155 "Leukemia, Lymphocytic, Chronic, B-Cell" 28407516 Quantitative miR analysis in chronic lymphocytic leukaemia/small lymphocytic lymphoma - proliferation centres are characterized by high miR-92a and miR-155 and low miR-150 expression. -circulation_biomarker_diagnosis_up hsa-mir-92a "Leukemia, Lymphocytic, Chronic, B-Cell" 28407516 Quantitative miR analysis in chronic lymphocytic leukaemia/small lymphocytic lymphoma - proliferation centres are characterized by high miR-92a and miR-155 and low miR-150 expression. -circulation_biomarker_diagnosis_up hsa-mir-125b "Leukemia-Lymphoma, Precursor B-Cell Lymphoblastic" 28415578 High expression of miR-125b-2 and SNORD116 noncoding RNA clusters characterize ERG-related B cell precursor acute lymphoblastic leukemia. -circulation_biomarker_diagnosis_up hsa-mir-21 Vascular Disease [unspecific] 28464406 "miR-21 and miR-92 levels increased, but did not reach the level of significance" -circulation_biomarker_diagnosis_up hsa-mir-92 Vascular Disease [unspecific] 28464406 "miR-21 and miR-92 levels increased, but did not reach the level of significance" -circulation_biomarker_diagnosis_up hsa-mir-196b "Leukemia, Myeloid, Acute" 28507466 High level of miR-196b at newly diagnosed pediatric acute myeloid leukemia predicts a poor outcome. -circulation_biomarker_diagnosis_up hsa-mir-155 Human Immunodeficiency Virus Infection 28627655 Elevated expression of miR-155 is associated with the differentiation of CD8+ T cells in patients with HIV-1. -circulation_biomarker_diagnosis_up hsa-mir-125b Rheumatoid Arthritis 28738524 Elevated microRNA-125b promotes inflammation in rheumatoid arthritis by activation of NF-¦ÊB pathway. -circulation_biomarker_diagnosis_up hsa-mir-126 Coronary Artery Disease 28751542 "patients with stenosis showed an increase of circulating miRNA-21, miRNA-126-3p, and miRNA-222 in response to cardiac stress" -circulation_biomarker_diagnosis_up hsa-mir-21 Coronary Artery Disease 28751542 "patients with stenosis showed an increase of circulating miRNA-21, miRNA-126-3p, and miRNA-222 in response to cardiac stress" -circulation_biomarker_diagnosis_up hsa-mir-222 Coronary Artery Disease 28751542 "patients with stenosis showed an increase of circulating miRNA-21, miRNA-126-3p, and miRNA-222 in response to cardiac stress" -circulation_biomarker_diagnosis_up hsa-mir-146a Osteoarthritis 28785809 "MBT can modify the expression of miR-155, miR-181a, miR-146a, and miR-223, which are upregulated in OA" -circulation_biomarker_diagnosis_up hsa-mir-155 Osteoarthritis 28785809 "MBT can modify the expression of miR-155, miR-181a, miR-146a, and miR-223, which are upregulated in OA" -circulation_biomarker_diagnosis_up hsa-mir-181a Osteoarthritis 28785809 "MBT can modify the expression of miR-155, miR-181a, miR-146a, and miR-223, which are upregulated in OA" -circulation_biomarker_diagnosis_up hsa-mir-223 Osteoarthritis 28785809 "MBT can modify the expression of miR-155, miR-181a, miR-146a, and miR-223, which are upregulated in OA" -circulation_biomarker_diagnosis_up hsa-mir-21 Human Immunodeficiency Virus Infection 28968466 upregulation of hsa-miR-21 and hsa-miR-222 by Tat may contribute to protect against apoptosis and to anergy observed in HIV-infected CD4+ T cells -circulation_biomarker_diagnosis_up hsa-mir-222 Human Immunodeficiency Virus Infection 28968466 upregulation of hsa-miR-21 and hsa-miR-222 by Tat may contribute to protect against apoptosis and to anergy observed in HIV-infected CD4+ T cells -circulation_biomarker_diagnosis_up hsa-mir-19b "Leukemia, Myeloid, Acute" 29032147 High bone marrow miR-19b level predicts poor prognosis and disease recurrence in de novo acute myeloid leukemia. -circulation_biomarker_diagnosis_up hsa-mir-144 Arrhythmia 29036525 "Plasma levels of miR-144-3p, 145-5p, 185-5p, and 494 were significantly elevated in definite ARVC patients with VA" -circulation_biomarker_diagnosis_up hsa-mir-145 Arrhythmia 29036525 "Plasma levels of miR-144-3p, 145-5p, 185-5p, and 494 were significantly elevated in definite ARVC patients with VA" -circulation_biomarker_diagnosis_up hsa-mir-185 Arrhythmia 29036525 "Plasma levels of miR-144-3p, 145-5p, 185-5p, and 494 were significantly elevated in definite ARVC patients with VA" -circulation_biomarker_diagnosis_up hsa-mir-494 Arrhythmia 29036525 "Plasma levels of miR-144-3p, 145-5p, 185-5p, and 494 were significantly elevated in definite ARVC patients with VA" -circulation_biomarker_diagnosis_up hsa-mir-146b Intrahepatic Cholangiocarcinoma 29095255 Both plasma and tumor tissue miR-146a high expression correlates with prolonged overall survival of surgical patients with intrahepatic cholangiocarcinoma. -circulation_biomarker_diagnosis_up hsa-let-7g Migraine 29126355 " migraine patients had upregulated expression of miR-155 (6.17-fold, p?=?0.018), miR-126 (6.17-fold, p?=?0.013), and let-7g (7.37-fold, p?=?0.005)" -circulation_biomarker_diagnosis_up hsa-mir-126 Migraine 29126355 " migraine patients had upregulated expression of miR-155 (6.17-fold, p?=?0.018), miR-126 (6.17-fold, p?=?0.013), and let-7g (7.37-fold, p?=?0.005)" -circulation_biomarker_diagnosis_up hsa-mir-155 Migraine 29126355 " migraine patients had upregulated expression of miR-155 (6.17-fold, p?=?0.018), miR-126 (6.17-fold, p?=?0.013), and let-7g (7.37-fold, p?=?0.005)" -circulation_biomarker_diagnosis_up hsa-mir-1 Myocardial Infarction 29150941 significantly elevated levels of miRNA-1 in post-MI old heart could be predictive of cardiac injury in older mice as the high risk biomarker for MI in older individuals -circulation_biomarker_diagnosis_up hsa-mir-210 Neoplasms [unspecific] 29187235 miR-210 was >?sixfold higher in the TCC group compared to the control group -circulation_biomarker_diagnosis_up hsa-mir-139 Rheumatoid Arthritis 29191214 "The expression levels of miR-139-3p, miR-204, miR-214, and miR-760 increased in RA patients receiving biologic agents" -circulation_biomarker_diagnosis_up hsa-mir-204 Rheumatoid Arthritis 29191214 "The expression levels of miR-139-3p, miR-204, miR-214, and miR-760 increased in RA patients receiving biologic agents" -circulation_biomarker_diagnosis_up hsa-mir-214 Rheumatoid Arthritis 29191214 "The expression levels of miR-139-3p, miR-204, miR-214, and miR-760 increased in RA patients receiving biologic agents" -circulation_biomarker_diagnosis_up hsa-mir-760 Rheumatoid Arthritis 29191214 "The expression levels of miR-139-3p, miR-204, miR-214, and miR-760 increased in RA patients receiving biologic agents" -circulation_biomarker_diagnosis_up hsa-mir-21 Myocardial Infarction 29197221 "Expression of miRNA-21 was upregulated in the serum of elderly patients with AMI, which inhibited TNF-a induced apoptosis in HCM by activating the JNK/p38/caspase-3 signaling pathway" -circulation_biomarker_diagnosis_up hsa-mir-126 Multiple Sclerosis 29325906 "The upregulation of miR-126-3p, miR-146b-5p, miR-155, miR-196a-5p, miR-21-5p, miR-223-3p, miR-326 and miR-379-5p in remission compared to relapse was observed" -circulation_biomarker_diagnosis_up hsa-mir-146b Multiple Sclerosis 29325906 "The upregulation of miR-126-3p, miR-146b-5p, miR-155, miR-196a-5p, miR-21-5p, miR-223-3p, miR-326 and miR-379-5p in remission compared to relapse was observed" -circulation_biomarker_diagnosis_up hsa-mir-155 Multiple Sclerosis 29325906 "The upregulation of miR-126-3p, miR-146b-5p, miR-155, miR-196a-5p, miR-21-5p, miR-223-3p, miR-326 and miR-379-5p in remission compared to relapse was observed" -circulation_biomarker_diagnosis_up hsa-mir-196a Multiple Sclerosis 29325906 "The upregulation of miR-126-3p, miR-146b-5p, miR-155, miR-196a-5p, miR-21-5p, miR-223-3p, miR-326 and miR-379-5p in remission compared to relapse was observed" -circulation_biomarker_diagnosis_up hsa-mir-21 Multiple Sclerosis 29325906 "The upregulation of miR-126-3p, miR-146b-5p, miR-155, miR-196a-5p, miR-21-5p, miR-223-3p, miR-326 and miR-379-5p in remission compared to relapse was observed" -circulation_biomarker_diagnosis_up hsa-mir-223 Multiple Sclerosis 29325906 "The upregulation of miR-126-3p, miR-146b-5p, miR-155, miR-196a-5p, miR-21-5p, miR-223-3p, miR-326 and miR-379-5p in remission compared to relapse was observed" -circulation_biomarker_diagnosis_up hsa-mir-326 Multiple Sclerosis 29325906 "The upregulation of miR-126-3p, miR-146b-5p, miR-155, miR-196a-5p, miR-21-5p, miR-223-3p, miR-326 and miR-379-5p in remission compared to relapse was observed" -circulation_biomarker_diagnosis_up hsa-mir-379 Multiple Sclerosis 29325906 "The upregulation of miR-126-3p, miR-146b-5p, miR-155, miR-196a-5p, miR-21-5p, miR-223-3p, miR-326 and miR-379-5p in remission compared to relapse was observed" -circulation_biomarker_diagnosis_up hsa-mir-21 Ovarian Neoplasms 29373877 miR-21 may be used as a diagnostic biomarker for human ovarian cancer -circulation_biomarker_diagnosis_up hsa-mir-191 Pancreatic Neoplasms 29385987 "An elevated expression of serum exosomal microRNA-191, -21, -451a of pancreatic neoplasm is considered to be efficient diagnostic marker" -circulation_biomarker_diagnosis_up hsa-mir-21 Pancreatic Neoplasms 29385987 "An elevated expression of serum exosomal microRNA-191, -21, -451a of pancreatic neoplasm is considered to be efficient diagnostic marker" -circulation_biomarker_diagnosis_up hsa-mir-451a Pancreatic Neoplasms 29385987 "An elevated expression of serum exosomal microRNA-191, -21, -451a of pancreatic neoplasm is considered to be efficient diagnostic marker" -circulation_biomarker_diagnosis_up hsa-mir-146b Stroke 29402769 upregulated serum miR-146b in acute ischemic stroke might be a potential biomarker for AIS evaluation -circulation_biomarker_diagnosis_up hsa-mir-210 Acute Cerebral Infarction 29434712 "miR-210 is upregulated in the serum of patients with ACI, and miR-210 may be involved in the pathogenesis of ACI through regulating the proliferation and apoptosis of endothelial cells" -circulation_biomarker_diagnosis_up hsa-mir-1 Cardiovascular Diseases [unspecific] 29506853 Plasma microRNAs reflecting cardiac and inflammatory injury in coronary artery bypass grafting surgery -circulation_biomarker_diagnosis_up hsa-mir-133a Cardiovascular Diseases [unspecific] 29506853 Plasma microRNAs reflecting cardiac and inflammatory injury in coronary artery bypass grafting surgery -circulation_biomarker_diagnosis_up hsa-mir-208a Cardiovascular Diseases [unspecific] 29506853 Plasma microRNAs reflecting cardiac and inflammatory injury in coronary artery bypass grafting surgery -circulation_biomarker_diagnosis_up hsa-mir-21 Cholangiocarcinoma 29516989 serum miR-21 was a promising biomarker for diagnosing the late stage CCA and would have potential to be a useful prognostic biomarker of CCA -circulation_biomarker_diagnosis_up hsa-mir-155 Hepatitis C Virus Infection 29528577 MicroRNA-155 is a relatively reliable marker for HCC detection -circulation_biomarker_diagnosis_up hsa-mir-208a Heart Failure 29559958 "miR-208a, a microRNA that is a key factor in promoting cardiovascular dysfunction during cardiac hypertrophy processes of heart failure, has its circulating levels increased during chronic indeterminate phase when compared to cardiac (CARD) clinical forms in patients with Chagas disease" -circulation_biomarker_diagnosis_up hsa-mir-21 Breast Neoplasms 29679553 "Assessment of miRNAs in serum samples can be applied as minimally non-invasive markers for early detection of breast cancer, and as discriminator between different clinicopathological characters" -circulation_biomarker_diagnosis_up hsa-mir-222 Breast Neoplasms 29679553 "Assessment of miRNAs in serum samples can be applied as minimally non-invasive markers for early detection of breast cancer, and as discriminator between different clinicopathological characters" -circulation_biomarker_diagnosis_up hsa-mir-373 Breast Neoplasms 29679553 "Assessment of miRNAs in serum samples can be applied as minimally non-invasive markers for early detection of breast cancer, and as discriminator between different clinicopathological characters" -circulation_biomarker_diagnosis_up hsa-mir-144 Familial Mediterranean Fever 29787577 "four miRNAs were upregulated (miR-144-3p, miR-21-5p, miR-4454, and miR-451a), and three were downregulated (miR-107, let-7d-5p, and miR-148b-3p)" -circulation_biomarker_diagnosis_up hsa-mir-21 Familial Mediterranean Fever 29787577 "four miRNAs were upregulated (miR-144-3p, miR-21-5p, miR-4454, and miR-451a), and three were downregulated (miR-107, let-7d-5p, and miR-148b-3p)" -circulation_biomarker_diagnosis_up hsa-mir-4454 Familial Mediterranean Fever 29787577 "four miRNAs were upregulated (miR-144-3p, miR-21-5p, miR-4454, and miR-451a), and three were downregulated (miR-107, let-7d-5p, and miR-148b-3p)" -circulation_biomarker_diagnosis_up hsa-mir-451a Familial Mediterranean Fever 29787577 "four miRNAs were upregulated (miR-144-3p, miR-21-5p, miR-4454, and miR-451a), and three were downregulated (miR-107, let-7d-5p, and miR-148b-3p)" -circulation_biomarker_diagnosis_up hsa-mir-21 "Leukemia, Myeloid" 29795410 MiR-21 was found to be normally upregulated in all types of ML -circulation_biomarker_diagnosis_up hsa-mir-300 Traumatic Brain Injury 29873258 miR-300-3p and miR-598-3p increased while miR-450-3p and miR-194-5p significantly decreased following TBI -circulation_biomarker_diagnosis_up hsa-mir-598 Traumatic Brain Injury 29873258 miR-300-3p and miR-598-3p increased while miR-450-3p and miR-194-5p significantly decreased following TBI -circulation_biomarker_diagnosis_up hsa-mir-195 "Diabetes Mellitus, Gestational" 29879500 "increased miRNA expression, especially miR-195-5p, in plasma is characteristic of and causally related to the development of GDM" -circulation_biomarker_diagnosis_up hsa-mir-144 "Carcinoma, Thyroid" 29885402 Evaluation of miRNAs expression in medullary thyroid carcinoma tissue samples: miR-34a and miR-144 as promising overexpressed markers in MTC. -circulation_biomarker_diagnosis_up hsa-mir-34a "Carcinoma, Thyroid" 29885402 Evaluation of miRNAs expression in medullary thyroid carcinoma tissue samples: miR-34a and miR-144 as promising overexpressed markers in MTC. -circulation_biomarker_diagnosis_up hsa-mir-223 Coronary Artery Disease 29888618 Association between elevated plasma microRNA-223 content and severity of coronary heart disease. -circulation_biomarker_diagnosis_up hsa-mir-4649 Chronic Brucellosis 29897958 The microRNA expression signature of CD4+ T cells in the transition of brucellosis into chronicity. -circulation_biomarker_diagnosis_up hsa-mir-182 Acute Lung Injury 29904430 "9 miRNAs were significantly upregulated (miR-1843-3p, miR-323-3p, miR-183-5p, miR-182 and miR-196b-3p) or downregulated (miR-547-3p, miR-301b-5p, miR-503-3p and miR-142-3p)" -circulation_biomarker_diagnosis_up hsa-mir-183 Acute Lung Injury 29904430 "9 miRNAs were significantly upregulated (miR-1843-3p, miR-323-3p, miR-183-5p, miR-182 and miR-196b-3p) or downregulated (miR-547-3p, miR-301b-5p, miR-503-3p and miR-142-3p)" -circulation_biomarker_diagnosis_up hsa-mir-1843 Acute Lung Injury 29904430 "9 miRNAs were significantly upregulated (miR-1843-3p, miR-323-3p, miR-183-5p, miR-182 and miR-196b-3p) or downregulated (miR-547-3p, miR-301b-5p, miR-503-3p and miR-142-3p)" -circulation_biomarker_diagnosis_up hsa-mir-196b Acute Lung Injury 29904430 "9 miRNAs were significantly upregulated (miR-1843-3p, miR-323-3p, miR-183-5p, miR-182 and miR-196b-3p) or downregulated (miR-547-3p, miR-301b-5p, miR-503-3p and miR-142-3p)" -circulation_biomarker_diagnosis_up hsa-mir-323 Acute Lung Injury 29904430 "9 miRNAs were significantly upregulated (miR-1843-3p, miR-323-3p, miR-183-5p, miR-182 and miR-196b-3p) or downregulated (miR-547-3p, miR-301b-5p, miR-503-3p and miR-142-3p)" -circulation_biomarker_diagnosis_up hsa-mir-135a Parkinson Disease 29935433 "We identified differential expression of 10 miRNA of which 5 were upregulated in PD (miR-9-5p, miR-135a-5p, miR-135b-5p, miR-449a, and miR-449b-5p) and 5 downregulated (miR-141-3p, miR-199a-5p, miR-299-5p, miR-518e-3p, and miR-519a-3p)" -circulation_biomarker_diagnosis_up hsa-mir-135b Parkinson Disease 29935433 "We identified differential expression of 10 miRNA of which 5 were upregulated in PD (miR-9-5p, miR-135a-5p, miR-135b-5p, miR-449a, and miR-449b-5p) and 5 downregulated (miR-141-3p, miR-199a-5p, miR-299-5p, miR-518e-3p, and miR-519a-3p)" -circulation_biomarker_diagnosis_up hsa-mir-449a Parkinson Disease 29935433 "We identified differential expression of 10 miRNA of which 5 were upregulated in PD (miR-9-5p, miR-135a-5p, miR-135b-5p, miR-449a, and miR-449b-5p) and 5 downregulated (miR-141-3p, miR-199a-5p, miR-299-5p, miR-518e-3p, and miR-519a-3p)" -circulation_biomarker_diagnosis_up hsa-mir-449b Parkinson Disease 29935433 "We identified differential expression of 10 miRNA of which 5 were upregulated in PD (miR-9-5p, miR-135a-5p, miR-135b-5p, miR-449a, and miR-449b-5p) and 5 downregulated (miR-141-3p, miR-199a-5p, miR-299-5p, miR-518e-3p, and miR-519a-3p)" -circulation_biomarker_diagnosis_up hsa-mir-9 Parkinson Disease 29935433 "We identified differential expression of 10 miRNA of which 5 were upregulated in PD (miR-9-5p, miR-135a-5p, miR-135b-5p, miR-449a, and miR-449b-5p) and 5 downregulated (miR-141-3p, miR-199a-5p, miR-299-5p, miR-518e-3p, and miR-519a-3p)" -circulation_biomarker_diagnosis_up hsa-mir-101a Peripheral Nerve Injury 29960630 "4 miRs (miR-101a, miR-138, miR-338, and miR-142) levels were finally validated for over-expression by quantitative (PCR) reaction" -circulation_biomarker_diagnosis_up hsa-mir-138 Peripheral Nerve Injury 29960630 "4 miRs (miR-101a, miR-138, miR-338, and miR-142) levels were finally validated for over-expression by quantitative (PCR) reaction" -circulation_biomarker_diagnosis_up hsa-mir-142 Peripheral Nerve Injury 29960630 "4 miRs (miR-101a, miR-138, miR-338, and miR-142) levels were finally validated for over-expression by quantitative (PCR) reaction" -circulation_biomarker_diagnosis_up hsa-mir-338 Peripheral Nerve Injury 29960630 "4 miRs (miR-101a, miR-138, miR-338, and miR-142) levels were finally validated for over-expression by quantitative (PCR) reaction" -circulation_biomarker_diagnosis_up hsa-mir-551b Acute Pancreatitis 29989302 Elevated Level of miR-551b-5p is Associated With Inflammation and Disease Progression in Patients With Severe Acute Pancreatitis. -circulation_biomarker_diagnosis_up hsa-mir-133a Glycogen Storage Disease II 29997386 miR-133a levels were significantly higher in Pompe disease patients than in controls and correlated with phenotype severity -circulation_biomarker_diagnosis_up hsa-mir-221 Hypertrophy 30009269 an elevated miR-221 level is potentially associated with an increased risk of SCD in subjects with cardiac hypertrophy -circulation_biomarker_diagnosis_up hsa-mir-10a Diabetic Nephropathy 30019103 "three up-regulated (miR-21-5p, miR-146a-5p, miR-10a-5p) and two down-regulated (miR-25-3p and miR-26a-5p) miRNAs" -circulation_biomarker_diagnosis_up hsa-mir-146a Diabetic Nephropathy 30019103 "three up-regulated (miR-21-5p, miR-146a-5p, miR-10a-5p) and two down-regulated (miR-25-3p and miR-26a-5p) miRNAs" -circulation_biomarker_diagnosis_up hsa-mir-21 Diabetic Nephropathy 30019103 "three up-regulated (miR-21-5p, miR-146a-5p, miR-10a-5p) and two down-regulated (miR-25-3p and miR-26a-5p) miRNAs" -circulation_biomarker_diagnosis_up hsa-mir-462a Anemia 30041004 "two miRNAs, miR-462a-5p and miR-125b-5p, showed increased and decreased expression, respectively, during ISAV infection" -circulation_biomarker_diagnosis_up hsa-mir-103 Colorectal Carcinoma 30058684 Upregulation of serum miR-103 predicts unfavorable prognosis in patients with colorectal cancer. -circulation_biomarker_diagnosis_up hsa-mir-100 "Squamous Cell Carcinoma, Esophageal" 30127929 "Among the 5 miRNAs considered (miR-21, miR-223, miR-375, miR-25 and miR-100), miR-21 and miR-223 were significantly overexpressed whereas miR-375 expression was reduced in patients with ESCC compared with healthy individuals" -circulation_biomarker_diagnosis_up hsa-mir-21 "Squamous Cell Carcinoma, Esophageal" 30127929 "Among the 5 miRNAs considered (miR-21, miR-223, miR-375, miR-25 and miR-100), miR-21 and miR-223 were significantly overexpressed whereas miR-375 expression was reduced in patients with ESCC compared with healthy individuals" -circulation_biomarker_diagnosis_up hsa-mir-223 "Squamous Cell Carcinoma, Esophageal" 30127929 "Among the 5 miRNAs considered (miR-21, miR-223, miR-375, miR-25 and miR-100), miR-21 and miR-223 were significantly overexpressed whereas miR-375 expression was reduced in patients with ESCC compared with healthy individuals" -circulation_biomarker_diagnosis_up hsa-mir-25 "Squamous Cell Carcinoma, Esophageal" 30127929 "Among the 5 miRNAs considered (miR-21, miR-223, miR-375, miR-25 and miR-100), miR-21 and miR-223 were significantly overexpressed whereas miR-375 expression was reduced in patients with ESCC compared with healthy individuals" -circulation_biomarker_diagnosis_up hsa-mir-125b Multiple Myeloma 30128020 The diagnostic and prognostic value of plasma microRNA-125b-5p in patients with multiple myeloma. -circulation_biomarker_diagnosis_up hsa-mir-221 Rheumatoid Arthritis 30132091 Upregulation of miR-221/222 expression in rheumatoid arthritis (RA) patients: correlation with disease activity. -circulation_biomarker_diagnosis_up hsa-mir-222 Rheumatoid Arthritis 30132091 Upregulation of miR-221/222 expression in rheumatoid arthritis (RA) patients: correlation with disease activity. -circulation_biomarker_diagnosis_up hsa-mir-1255a Stroke 30135469 "six microRNAs showed significantly increased expression - miR-371-3p, miR-524, miR-520g, miR-1255A, miR-453, and miR-583, while 3 showed significantly decreased expression - miR-941, miR-449b, and miR-581" -circulation_biomarker_diagnosis_up hsa-mir-371 Stroke 30135469 "six microRNAs showed significantly increased expression - miR-371-3p, miR-524, miR-520g, miR-1255A, miR-453, and miR-583, while 3 showed significantly decreased expression - miR-941, miR-449b, and miR-581" -circulation_biomarker_diagnosis_up hsa-mir-453 Stroke 30135469 "six microRNAs showed significantly increased expression - miR-371-3p, miR-524, miR-520g, miR-1255A, miR-453, and miR-583, while 3 showed significantly decreased expression - miR-941, miR-449b, and miR-581" -circulation_biomarker_diagnosis_up hsa-mir-520g Stroke 30135469 "six microRNAs showed significantly increased expression - miR-371-3p, miR-524, miR-520g, miR-1255A, miR-453, and miR-583, while 3 showed significantly decreased expression - miR-941, miR-449b, and miR-581" -circulation_biomarker_diagnosis_up hsa-mir-524 Stroke 30135469 "six microRNAs showed significantly increased expression - miR-371-3p, miR-524, miR-520g, miR-1255A, miR-453, and miR-583, while 3 showed significantly decreased expression - miR-941, miR-449b, and miR-581" -circulation_biomarker_diagnosis_up hsa-mir-583 Stroke 30135469 "six microRNAs showed significantly increased expression - miR-371-3p, miR-524, miR-520g, miR-1255A, miR-453, and miR-583, while 3 showed significantly decreased expression - miR-941, miR-449b, and miR-581" -circulation_biomarker_diagnosis_up hsa-mir-125a "Diabetes Mellitus, Type 2" 30150203 Up regulation of miR-125a in WAT of type 2 Diabetes mellitus have been observed -circulation_biomarker_diagnosis_up hsa-mir-148a Prostate Neoplasms 30160020 Increased levels of serum miR-148a-3p are associated with prostate cancer. -circulation_biomarker_diagnosis_up hsa-mir-122 Obesity 30160046 Pilot study on circulating miRNA signature in children with obesity born small for gestational age and appropriate for gestational age. -circulation_biomarker_diagnosis_up hsa-mir-423 Obesity 30160046 Pilot study on circulating miRNA signature in children with obesity born small for gestational age and appropriate for gestational age. -circulation_biomarker_diagnosis_up hsa-mir-484 Obesity 30160046 Pilot study on circulating miRNA signature in children with obesity born small for gestational age and appropriate for gestational age. -circulation_biomarker_diagnosis_up hsa-mir-486 Obesity 30160046 Pilot study on circulating miRNA signature in children with obesity born small for gestational age and appropriate for gestational age. -circulation_biomarker_diagnosis_up hsa-mir-532 Obesity 30160046 Pilot study on circulating miRNA signature in children with obesity born small for gestational age and appropriate for gestational age. -circulation_biomarker_diagnosis_up hsa-mir-92a Obesity 30160046 Pilot study on circulating miRNA signature in children with obesity born small for gestational age and appropriate for gestational age. -circulation_biomarker_diagnosis_up hsa-let-7i Diabetic Nephropathy 30165157 "a urinary EV miRNA signature was found to comprise increased levels of let-7i-3p, miR-24-3p and miR-27b-3p, and decreased levels of miR-15b-5p, to identify patients with MIC" -circulation_biomarker_diagnosis_up hsa-mir-24 Diabetic Nephropathy 30165157 "a urinary EV miRNA signature was found to comprise increased levels of let-7i-3p, miR-24-3p and miR-27b-3p, and decreased levels of miR-15b-5p, to identify patients with MIC" -circulation_biomarker_diagnosis_up hsa-mir-27b Diabetic Nephropathy 30165157 "a urinary EV miRNA signature was found to comprise increased levels of let-7i-3p, miR-24-3p and miR-27b-3p, and decreased levels of miR-15b-5p, to identify patients with MIC" -circulation_biomarker_diagnosis_up hsa-mir-21 Diabetic Nephropathy 30167868 "In the validation sample, miR-21-3p and miR-378-3p were confirmed to be upregulated in patients with severe DKD, while miR-16-5p and miR-29a-3p were downregulated in this group compared to T1DM controls and patients with moderate DKD" -circulation_biomarker_diagnosis_up hsa-mir-378 Diabetic Nephropathy 30167868 "In the validation sample, miR-21-3p and miR-378-3p were confirmed to be upregulated in patients with severe DKD, while miR-16-5p and miR-29a-3p were downregulated in this group compared to T1DM controls and patients with moderate DKD" -circulation_biomarker_diagnosis_up hsa-mir-203 "Carcinoma, Cervical" 30191988 "The upregulation of some circulating miRNAs, for example, miRNA-20a, miRNA-203, miRNA-21, miRNA-205, miRNA-218, and miR-485-5, as well as tissue-specific miRNAs, for example, miR-7, miR-10a, miR-17-5p, miR-135b, miR-149, and miR-203 have been found in patients with CC" -circulation_biomarker_diagnosis_up hsa-mir-205 "Carcinoma, Cervical" 30191988 "The upregulation of some circulating miRNAs, for example, miRNA-20a, miRNA-203, miRNA-21, miRNA-205, miRNA-218, and miR-485-5, as well as tissue-specific miRNAs, for example, miR-7, miR-10a, miR-17-5p, miR-135b, miR-149, and miR-203 have been found in patients with CC" -circulation_biomarker_diagnosis_up hsa-mir-20a "Carcinoma, Cervical" 30191988 "The upregulation of some circulating miRNAs, for example, miRNA-20a, miRNA-203, miRNA-21, miRNA-205, miRNA-218, and miR-485-5, as well as tissue-specific miRNAs, for example, miR-7, miR-10a, miR-17-5p, miR-135b, miR-149, and miR-203 have been found in patients with CC" -circulation_biomarker_diagnosis_up hsa-mir-21 "Carcinoma, Cervical" 30191988 "The upregulation of some circulating miRNAs, for example, miRNA-20a, miRNA-203, miRNA-21, miRNA-205, miRNA-218, and miR-485-5, as well as tissue-specific miRNAs, for example, miR-7, miR-10a, miR-17-5p, miR-135b, miR-149, and miR-203 have been found in patients with CC" -circulation_biomarker_diagnosis_up hsa-mir-218 "Carcinoma, Cervical" 30191988 "The upregulation of some circulating miRNAs, for example, miRNA-20a, miRNA-203, miRNA-21, miRNA-205, miRNA-218, and miR-485-5, as well as tissue-specific miRNAs, for example, miR-7, miR-10a, miR-17-5p, miR-135b, miR-149, and miR-203 have been found in patients with CC" -circulation_biomarker_diagnosis_up hsa-mir-485 "Carcinoma, Cervical" 30191988 "The upregulation of some circulating miRNAs, for example, miRNA-20a, miRNA-203, miRNA-21, miRNA-205, miRNA-218, and miR-485-5, as well as tissue-specific miRNAs, for example, miR-7, miR-10a, miR-17-5p, miR-135b, miR-149, and miR-203 have been found in patients with CC" -circulation_biomarker_diagnosis_up hsa-mir-20a "Diabetes Mellitus, Type 1" 30194557 "Increased expression of microRNAs, miR-20a and miR-326 in PBMCs of patients with type 1 diabetes." -circulation_biomarker_diagnosis_up hsa-mir-326 "Diabetes Mellitus, Type 1" 30194557 "Increased expression of microRNAs, miR-20a and miR-326 in PBMCs of patients with type 1 diabetes." -circulation_biomarker_diagnosis_up hsa-mir-150 "Diabetes Mellitus, Type 2" 30195754 "Cox regression analyses showed that patients with low miR-103, miR-28-3p, miR-29a, and miR-9 and high miR-30a-5p and miR-150 circulating levels have a higher risk of disease" -circulation_biomarker_diagnosis_up hsa-mir-30a "Diabetes Mellitus, Type 2" 30195754 "Cox regression analyses showed that patients with low miR-103, miR-28-3p, miR-29a, and miR-9 and high miR-30a-5p and miR-150 circulating levels have a higher risk of disease" -circulation_biomarker_diagnosis_up hsa-mir-126 Obesity 30248300 Circulating microRNAs are upregulated following acute aerobic exercise in obese individuals. -circulation_biomarker_diagnosis_up hsa-mir-130b Obesity 30248300 Circulating microRNAs are upregulated following acute aerobic exercise in obese individuals. -circulation_biomarker_diagnosis_up hsa-mir-21 Obesity 30248300 Circulating microRNAs are upregulated following acute aerobic exercise in obese individuals. -circulation_biomarker_diagnosis_up hsa-mir-221 Obesity 30248300 Circulating microRNAs are upregulated following acute aerobic exercise in obese individuals. -circulation_biomarker_diagnosis_up hsa-mir-222 Obesity 30248300 Circulating microRNAs are upregulated following acute aerobic exercise in obese individuals. -circulation_biomarker_diagnosis_up hsa-mir-26a Parkinson Disease 30267378 "Parkinsonian rats presented a significant increase in miR-26a and miR-34a, while miR-7 and Let7a were downregulated" -circulation_biomarker_diagnosis_up hsa-mir-34a Parkinson Disease 30267378 "Parkinsonian rats presented a significant increase in miR-26a and miR-34a, while miR-7 and Let7a were downregulated" -circulation_biomarker_diagnosis_up hsa-mir-1 Hyperactivity Disorder 30270454 "three miRNAs (miR-1-b, miR-741-3p, and miR-206-3p) were upregulated and four (miR-182, miR-471-5p, miR-183-5p, and miR-211-5p) were downregulated in the SHR group compared with the WKY group" -circulation_biomarker_diagnosis_up hsa-mir-206 Hyperactivity Disorder 30270454 "three miRNAs (miR-1-b, miR-741-3p, and miR-206-3p) were upregulated and four (miR-182, miR-471-5p, miR-183-5p, and miR-211-5p) were downregulated in the SHR group compared with the WKY group" -circulation_biomarker_diagnosis_up hsa-mir-741 Hyperactivity Disorder 30270454 "three miRNAs (miR-1-b, miR-741-3p, and miR-206-3p) were upregulated and four (miR-182, miR-471-5p, miR-183-5p, and miR-211-5p) were downregulated in the SHR group compared with the WKY group" -circulation_biomarker_diagnosis_up hsa-mir-106b Preeclampsia 30277561 "There was significant upregulation of miR-106b and miR-326 ( p?=?0.0048 and 0.028, respectively) in PE patients in comparison with the control group" -circulation_biomarker_diagnosis_up hsa-mir-326 Preeclampsia 30277561 "There was significant upregulation of miR-106b and miR-326 ( p?=?0.0048 and 0.028, respectively) in PE patients in comparison with the control group" -circulation_biomarker_diagnosis_up hsa-mir-1260b Aplastic Anemia 30298490 expression of miR-155-5p and miR-1260b were increased in both CAA and SAA patients compared with the normal controls -circulation_biomarker_diagnosis_up hsa-mir-155 Aplastic Anemia 30298490 expression of miR-155-5p and miR-1260b were increased in both CAA and SAA patients compared with the normal controls -circulation_biomarker_diagnosis_up hsa-mir-30a Heart Diseases [unspecific] 30308506 "Five miRNAs were upregulated (hsa-miR-4508, hsa-miR-novel-chr8_87373, hsa-miR-30a-3p, hsa-miR-novel-chr16_26099, hsa-miR-4306) and seven miRNAs (hsa-miR-744-5p, hsa-miR-320a, hsa-miR-novel-chr9_90035, hsa-miR-101-3p, hsa-miR-150-5p, hsa-miR-342-3p, and hsa-miR-140-3p) were downregulated" -circulation_biomarker_diagnosis_up hsa-mir-4306 Heart Diseases [unspecific] 30308506 "Five miRNAs were upregulated (hsa-miR-4508, hsa-miR-novel-chr8_87373, hsa-miR-30a-3p, hsa-miR-novel-chr16_26099, hsa-miR-4306) and seven miRNAs (hsa-miR-744-5p, hsa-miR-320a, hsa-miR-novel-chr9_90035, hsa-miR-101-3p, hsa-miR-150-5p, hsa-miR-342-3p, and hsa-miR-140-3p) were downregulated" -circulation_biomarker_diagnosis_up hsa-mir-4508 Heart Diseases [unspecific] 30308506 "Five miRNAs were upregulated (hsa-miR-4508, hsa-miR-novel-chr8_87373, hsa-miR-30a-3p, hsa-miR-novel-chr16_26099, hsa-miR-4306) and seven miRNAs (hsa-miR-744-5p, hsa-miR-320a, hsa-miR-novel-chr9_90035, hsa-miR-101-3p, hsa-miR-150-5p, hsa-miR-342-3p, and hsa-miR-140-3p) were downregulated" -circulation_biomarker_diagnosis_up hsa-mir-130 Metabolic Syndrome 30309709 "increased concentrations of miRNAS; miR-142-3p, miR-140-5p, miR-222 miR-143, miR-130, and decreased concentrations of miR-532-5p, miR-423-5p,miR-520c-3p, miR-146a, and miR-15a" -circulation_biomarker_diagnosis_up hsa-mir-140 Metabolic Syndrome 30309709 "increased concentrations of miRNAS; miR-142-3p, miR-140-5p, miR-222 miR-143, miR-130, and decreased concentrations of miR-532-5p, miR-423-5p,miR-520c-3p, miR-146a, and miR-15a" -circulation_biomarker_diagnosis_up hsa-mir-142 Metabolic Syndrome 30309709 "increased concentrations of miRNAS; miR-142-3p, miR-140-5p, miR-222 miR-143, miR-130, and decreased concentrations of miR-532-5p, miR-423-5p,miR-520c-3p, miR-146a, and miR-15a" -circulation_biomarker_diagnosis_up hsa-mir-143 Metabolic Syndrome 30309709 "increased concentrations of miRNAS; miR-142-3p, miR-140-5p, miR-222 miR-143, miR-130, and decreased concentrations of miR-532-5p, miR-423-5p,miR-520c-3p, miR-146a, and miR-15a" -circulation_biomarker_diagnosis_up hsa-mir-222 Metabolic Syndrome 30309709 "increased concentrations of miRNAS; miR-142-3p, miR-140-5p, miR-222 miR-143, miR-130, and decreased concentrations of miR-532-5p, miR-423-5p,miR-520c-3p, miR-146a, and miR-15a" -circulation_biomarker_diagnosis_up hsa-mir-135b Colon Neoplasms 30311185 "the expression of the miR-135b, miR-155, and KRAS was increased in the AOM group compared to the control group in both the plasma and the colon tissue samples" -circulation_biomarker_diagnosis_up hsa-mir-155 Colon Neoplasms 30311185 "the expression of the miR-135b, miR-155, and KRAS was increased in the AOM group compared to the control group in both the plasma and the colon tissue samples" -circulation_biomarker_diagnosis_up hsa-mir-144 Atopic Dermatitis 30312706 Hsa-mir-144-3p is increased in umbilical cord serum of infants developing atopic dermatitis. -circulation_biomarker_diagnosis_up hsa-mir-106b Behcet Disease 30317557 "T-cell-associated miRNA expression levels, miR-25, miR-106b, miR-326, and miR-93 were significantly upregulated, while miR-146a and miR-155 levels were lower in PBMCs of patients with BD" -circulation_biomarker_diagnosis_up hsa-mir-25 Behcet Disease 30317557 "T-cell-associated miRNA expression levels, miR-25, miR-106b, miR-326, and miR-93 were significantly upregulated, while miR-146a and miR-155 levels were lower in PBMCs of patients with BD" -circulation_biomarker_diagnosis_up hsa-mir-326 Behcet Disease 30317557 "T-cell-associated miRNA expression levels, miR-25, miR-106b, miR-326, and miR-93 were significantly upregulated, while miR-146a and miR-155 levels were lower in PBMCs of patients with BD" -circulation_biomarker_diagnosis_up hsa-mir-93 Behcet Disease 30317557 "T-cell-associated miRNA expression levels, miR-25, miR-106b, miR-326, and miR-93 were significantly upregulated, while miR-146a and miR-155 levels were lower in PBMCs of patients with BD" -circulation_biomarker_diagnosis_up hsa-mir-339 Amyloidosis 30332417 MiR-339-3p was increased in blood of patients with senile cardiac amyloidosis -circulation_biomarker_diagnosis-down hsa-mir-181b Obesity 30160046 Pilot study on circulating miRNA signature in children with obesity born small for gestational age and appropriate for gestational age. -circulation_biomarker_prognosis_down hsa-mir-326 Multiple Sclerosis 25642434 "Our longitudinal analysis revealed that miR-18a, miR-20b, miR-29a, and miR-103 were upregulated and predominantly expressed by CD4(+) T cells, whereas miR-326 was downregulated upon natalizumab treatment." -circulation_biomarker_prognosis_down hsa-let-7a-1 Lung Neoplasms 17940623 Studies by Takamizawa et al. and Yanaihara et al. have presented evidence that transcripts of certain let-7 homologs are significantly downregulated in human lung cancer and that low levels of let-7 correlate with poor prognosis. -circulation_biomarker_prognosis_down hsa-let-7a-2 Lung Neoplasms 17940623 Studies by Takamizawa et al. and Yanaihara et al. have presented evidence that transcripts of certain let-7 homologs are significantly downregulated in human lung cancer and that low levels of let-7 correlate with poor prognosis. -circulation_biomarker_prognosis_down hsa-let-7a-3 Lung Neoplasms 17940623 Studies by Takamizawa et al. and Yanaihara et al. have presented evidence that transcripts of certain let-7 homologs are significantly downregulated in human lung cancer and that low levels of let-7 correlate with poor prognosis. -circulation_biomarker_prognosis_down hsa-let-7b Lung Neoplasms 17940623 Studies by Takamizawa et al. and Yanaihara et al. have presented evidence that transcripts of certain let-7 homologs are significantly downregulated in human lung cancer and that low levels of let-7 correlate with poor prognosis. -circulation_biomarker_prognosis_down hsa-let-7c Lung Neoplasms 17940623 Studies by Takamizawa et al. and Yanaihara et al. have presented evidence that transcripts of certain let-7 homologs are significantly downregulated in human lung cancer and that low levels of let-7 correlate with poor prognosis. -circulation_biomarker_prognosis_down hsa-let-7d Lung Neoplasms 17940623 Studies by Takamizawa et al. and Yanaihara et al. have presented evidence that transcripts of certain let-7 homologs are significantly downregulated in human lung cancer and that low levels of let-7 correlate with poor prognosis. -circulation_biomarker_prognosis_down hsa-let-7e Lung Neoplasms 17940623 Studies by Takamizawa et al. and Yanaihara et al. have presented evidence that transcripts of certain let-7 homologs are significantly downregulated in human lung cancer and that low levels of let-7 correlate with poor prognosis. -circulation_biomarker_prognosis_down hsa-let-7f-1 Lung Neoplasms 17940623 Studies by Takamizawa et al. and Yanaihara et al. have presented evidence that transcripts of certain let-7 homologs are significantly downregulated in human lung cancer and that low levels of let-7 correlate with poor prognosis. -circulation_biomarker_prognosis_down hsa-let-7f-2 Lung Neoplasms 17940623 Studies by Takamizawa et al. and Yanaihara et al. have presented evidence that transcripts of certain let-7 homologs are significantly downregulated in human lung cancer and that low levels of let-7 correlate with poor prognosis. -circulation_biomarker_prognosis_down hsa-let-7g Lung Neoplasms 17940623 Studies by Takamizawa et al. and Yanaihara et al. have presented evidence that transcripts of certain let-7 homologs are significantly downregulated in human lung cancer and that low levels of let-7 correlate with poor prognosis. -circulation_biomarker_prognosis_down hsa-let-7i Lung Neoplasms 17940623 Studies by Takamizawa et al. and Yanaihara et al. have presented evidence that transcripts of certain let-7 homologs are significantly downregulated in human lung cancer and that low levels of let-7 correlate with poor prognosis. -circulation_biomarker_prognosis_down hsa-mir-9-1 Waldenstrom Macroglobulinemia 19074725 miR-9*: decreased expression -circulation_biomarker_prognosis_down hsa-mir-9-2 Waldenstrom Macroglobulinemia 19074725 miR-9*: decreased expression -circulation_biomarker_prognosis_down hsa-mir-9-3 Waldenstrom Macroglobulinemia 19074725 miR-9*: decreased expression -circulation_biomarker_prognosis_down hsa-mir-195 Breast Neoplasms 20134314 circulating levels of miR-195 and let-7a decreased in cancer patients postoperatively -circulation_biomarker_prognosis_down hsa-mir-296 Colon Neoplasms 22892953 Decrease in blood miR-296 predicts chemotherapy resistance and poor clinical outcome in patients receiving systemic chemotherapy for metastatic colon cancer. -circulation_biomarker_prognosis_down hsa-mir-100 Urinary Bladder Cancer 23173870 Reduced expression of microRNA-100 confers unfavorable prognosis in patients with bladder cancer -circulation_biomarker_prognosis_down hsa-mir-150 Hypertension 23220912 Reduced miR-150 is Associated with Poor Survival in Pulmonary Arterial Hypertension -circulation_biomarker_prognosis_down hsa-mir-129-1 "Lymphoma, Large B-Cell, Diffuse" 23463124 Low expression of microRNA-129-5p predicts poor clinical outcome in diffuse large B cell lymphoma (DLBCL) -circulation_biomarker_prognosis_down hsa-mir-129-2 "Lymphoma, Large B-Cell, Diffuse" 23463124 Low expression of microRNA-129-5p predicts poor clinical outcome in diffuse large B cell lymphoma (DLBCL) -circulation_biomarker_prognosis_down hsa-mir-100 "Carcinoma, Hepatocellular" 23842624 Downregulation of microRNA-100 correlates with tumor progression and poor prognosis in hepatocellular carcinoma. -circulation_biomarker_prognosis_down hsa-mir-150 Myocardial Infarction 23967079 "We enrolled 150 patients after AMI. Blood samples were obtained at discharge for determination of N-terminal pro-brain natriuretic peptide (Nt-proBNP) and levels of miR-16, miR-27a, miR-101 and miR-150." -circulation_biomarker_prognosis_down hsa-mir-124-1 "Leukemia, Myeloid, Acute" 24135052 These findings suggest that miR-124-1 underexpression is a common event and might have a favorable impact on prognosis in AML. -circulation_biomarker_prognosis_down hsa-mir-34a Gastric Neoplasms 24232982 "Decreased miR-34a expression and increased FOXP1, p53, and BCL2 coexpression to predict a poor OS for MALT lymphoma and DLBCL patients could become very important prognostic markers in daily clinical work. Further investigation of these changes may be of prognostic significance in clinical practice." -circulation_biomarker_prognosis_down hsa-mir-146b "Lymphoma, Large B-Cell, Diffuse" 24931464 "Low expression of microRNA-146b-5p and microRNA-320d predicts poor outcome of large B-cell lymphoma treated with cyclophosphamide, doxorubicin, vincristine,and prednisone." -circulation_biomarker_prognosis_down hsa-mir-320d "Lymphoma, Large B-Cell, Diffuse" 24931464 "Low expression of microRNA-146b-5p and microRNA-320d predicts poor outcome of large B-cell lymphoma treated with cyclophosphamide, doxorubicin, vincristine,and prednisone." -circulation_biomarker_prognosis_down hsa-mir-19a Myeloma 25220540 Low serum miR-19a expression as a novel poor prognostic indicator in multiple myeloma. -circulation_biomarker_prognosis_down hsa-let-7g "Squamous Cell Carcinoma, Head and Neck" 25677760 "decreased expressions of miR-153, miR-200c, miR-363, miR-203, miR-17, miR-205, miR-Let-7d, Let-7g, miR-34a, miR-126a, miR-375, miR-491-p5, miR 218, miR-451 and miR-125b were associated with poor prognosis." -circulation_biomarker_prognosis_down hsa-mir-204 "Leukemia, Myeloid, Acute" 26126974 We showed low miR-204 expression in AML and found it to be an independent prognostic factor in this patient population. -circulation_biomarker_prognosis_down hsa-mir-328 "Leukemia, Myeloid, Acute" 26185105 Low expression of circulating microRNA-328 is associated with poor prognosis in patients with acute myeloid leukemia. -circulation_biomarker_prognosis_down hsa-mir-128 Prostate Neoplasms 26339409 "Our data suggest that the decreased expression of miR-128 in both tissue and serum samples of PCa patients may be associated with tumor malignant progression and BCR-free survival. Particularly, serum miR-128 may be developed as a novel noninvasive biomarker for PCa diagnosis and prognosis." -circulation_biomarker_prognosis_down hsa-mir-153 "Carcinoma, Lung, Non-Small-Cell" 26339455 "Decreased expression of miR-153 might be a potential unfavorable prognostic factor for patients with NSCLC, and further studies would be needed to prove our findings." -circulation_biomarker_prognosis_down hsa-mir-17 Preeclampsia 26339600 "ur data indicate that short-term exposure of 3A villous first trimester trophoblasts to H2O2 significantly alters miRNA profile and mRNA expression of genes implicated in defective placental development. Our data, which indicate that oxidative stress alters miRNAs and RNAs expression, could partially explain some of the early changes in gene expression profiles and miRNA observed in PE." -circulation_biomarker_prognosis_down hsa-mir-204 "Carcinoma, Lung, Non-Small-Cell" 26497897 Decreased expression of miR-204 in plasma is associated with a poor prognosis in patients with non-small cell lung cancer. -circulation_biomarker_prognosis_down hsa-mir-1 "Carcinoma, Hepatocellular" 26554254 Low miR-1 expression is associated with shortened survival time.MiR-1 may act as a potential prognostic biomarker for HCC patients. -circulation_biomarker_prognosis_down hsa-mir-1 Acute Heart Failure 26580972 admission levels of miR-1 were lower in AHF and stable CHF patients compared to non-AHF patients -circulation_biomarker_prognosis_down hsa-mir-218 "Carcinoma, Hepatocellular" 26586116 "Consequently, our findings revealed that serum miR-218 levels were remarkably underexpressed in HCC patients as compared to BLD patients and healthy controls." -circulation_biomarker_prognosis_down hsa-mir-100 Bladder Neoplasms 26662386 "The present study demonstrated that the downregulation of miR-100 was associated with advanced clinical features and poor prognosis for bladder cancer patients, suggesting that miR-100 downregulation may be used as an unfavorable prognostic biomarker in bladder cancer." -circulation_biomarker_prognosis_down hsa-mir-215 "Leukemia, Myeloid, Acute" 26802165 Our study demonstrates that reduced microRNA-215 expression is a common event and is associated with poor clinical outcome in acute myeloid leukemia. -circulation_biomarker_prognosis_down hsa-mir-16 Colorectal Carcinoma 26934556 Serum miR-16 levels were significantly lower in the high blood glucose patients -circulation_biomarker_prognosis_down hsa-mir-199a Ovarian Neoplasms 26951510 Expression of miR-199a was found to be significantly downregulated in comparison with matched normal controls. -circulation_biomarker_prognosis_down hsa-mir-200a Choriocarcinoma 27081702 "Eleven miRNAs were significantly different between R and NR (miR-154, miR-409-3p, miR-127-3p, miR-214*, miR-299-5p and miR-125b overexpressed in NR; miR-33a, miR-30e, miR-338-3p, miR-200a and miR-378 decreased)." -circulation_biomarker_prognosis_down hsa-mir-34a "Adenocarcinoma, Pancreatic Ductal" 27458977 "A loss of expression of miR-34a, but not of miR-150, is associated with disease progression and poor prognosis in PDAC patients, and may be involved in the chemoresistance of PDAC cells." -circulation_biomarker_prognosis_down hsa-mir-145 "Carcinoma, Gastric" 27460730 "MiR-145-5p is down-expressed in GC, and can be used as a marker of poor prognosis in GC patients." -circulation_biomarker_prognosis_down hsa-mir-1300 "Carcinoma, Colon" 27485175 Low expression of miR-1300 and miR-939 was significantly correlated with shorter distant metastasis-free survival (DMFS) in Cox univariate analysis (p.adjusted = 0.049). -circulation_biomarker_prognosis_down hsa-mir-939 "Carcinoma, Colon" 27485175 Low expression of miR-1300 and miR-939 was significantly correlated with shorter distant metastasis-free survival (DMFS) in Cox univariate analysis (p.adjusted = 0.049). -circulation_biomarker_prognosis_down hsa-mir-126 Arteriosclerosis Obliterans 27497911 "Furthermore, plasma miR-126-5p levels were significantly down-regulated in CAD patients with multi-vessel disease, higher SYNTAX score, rather than isolated LMCA and low SYNTAX score." -circulation_biomarker_prognosis_down hsa-mir-126 Coronary Artery Disease 27497911 "Furthermore, plasma miR-126-5p levels were significantly down-regulated in CAD patients with multi-vessel disease, higher SYNTAX score, rather than isolated LMCA and low SYNTAX score." -circulation_biomarker_prognosis_down hsa-mir-126 Myocardial Infarction 27497911 "Furthermore, plasma miR-126-5p levels were significantly down-regulated in CAD patients with multi-vessel disease, higher SYNTAX score, rather than isolated LMCA and low SYNTAX score." -circulation_biomarker_prognosis_down hsa-mir-30c "Carcinoma, Lung, Non-Small-Cell" 27506865 MiR-30c-2* negative regulated MTA-1 expression involved in metastasis and drug resistance of HPV-infected non-small cell lung cancer. -circulation_biomarker_prognosis_down hsa-mir-30c Human Papilloma Virus Infection 27506865 MiR-30c-2* negative regulated MTA-1 expression involved in metastasis and drug resistance of HPV-infected non-small cell lung cancer. -circulation_biomarker_prognosis_down hsa-mir-29c "Carcinoma, Hepatocellular" 27525839 Our findings demonstrate that miR-29c expression is significantly downregulated in HCC patients and that miR-29c can act as an independent predictor of unfavorable clinical outcome. -circulation_biomarker_prognosis_down hsa-mir-135a "Carcinoma, Lung, Non-Small-Cell" 27525941 "the serum miR-135a level was downregulated in NSCLC patients, and was associated with poor prognosis." -circulation_biomarker_prognosis_down hsa-mir-148a Gastric Neoplasms 27529338 Down-regulation of miR-26a and miR-148a was significantly associated with shorter OS of GC patients -circulation_biomarker_prognosis_down hsa-mir-26a Gastric Neoplasms 27529338 Down-regulation of miR-26a and miR-148a was significantly associated with shorter OS of GC patients -circulation_biomarker_prognosis_down hsa-mir-218 Neoplasms [unspecific] 27631228 Prognostic significance of low microRNA-218 expression in patients with different types of cancer: Evidence from published studies. -circulation_biomarker_prognosis_down hsa-mir-99a "Carcinoma, Breast" 27706621 Low levels of serum miR-99a is a predictor of poor prognosis in breast cancer. -circulation_biomarker_prognosis_down hsa-mir-146a Coronary Artery Disease 28050558 Reduced Plasma miR-146a Is a Predictor of Poor Coronary Collateral Circulation in Patients with Coronary Artery Disease. -circulation_biomarker_prognosis_down hsa-let-7i "Leukemia, Myeloid, Chronic" 28512058 Downregulation of miR-224 and let-7i contribute to cell survival and chemoresistance in chronic myeloid leukemia cells by regulating ST3GAL IV expression. -circulation_biomarker_prognosis_down hsa-mir-224 "Leukemia, Myeloid, Chronic" 28512058 Downregulation of miR-224 and let-7i contribute to cell survival and chemoresistance in chronic myeloid leukemia cells by regulating ST3GAL IV expression. -circulation_biomarker_prognosis_down hsa-mir-19a Breast Neoplasms 29189128 "up-regulation of miR181b, miR-34a, miR-16, miR-15a and miR-146b-5p, and down-regulation of miR-19a and miR-19b have been shown following the treatment of several breast cancer cell lines with curcumin" -circulation_biomarker_prognosis_down hsa-mir-19b Breast Neoplasms 29189128 "up-regulation of miR181b, miR-34a, miR-16, miR-15a and miR-146b-5p, and down-regulation of miR-19a and miR-19b have been shown following the treatment of several breast cancer cell lines with curcumin" -circulation_biomarker_prognosis_down hsa-mir-122 "Leukemia, Myeloid, Acute" 29627222 Lower expression of bone marrow miR-122 is an independent risk factor for overall survival in cytogenetically normal acute myeloid leukemia. -circulation_biomarker_prognosis_down hsa-mir-21 Atrial Fibrillation 29676832 "The miRNAs had different expression profiles dependent on the AF condition, with higher expression in the acute new-onset AF than well-controlled AF" -circulation_biomarker_prognosis_down hsa-mir-451 "Carcinoma, Breast" 30099860 "baseline miR-222 overexpression, C2 miR-20a up-regulation and C2 miR-451 down-regulation were predictive markers of response to NCT in HR+/HER2- breast cancer" -circulation_biomarker_prognosis_down hsa-mir-146a Osteoarthritis 30105874 "Circulating miRNA expression profiles act as important roles in knee OA patients underwent celecoxib treatment, and miR-126-5p, miR-320a as well as miR-146a-5p might correlate with treatment response to celecoxib" -circulation_biomarker_prognosis_down hsa-mir-130b "Carcinoma, Breast" 30109140 "postoperatively downregulated circulating miR-130b-5p, miR-151a-5p, miR-206, and miR-222-3p may be potential biomarkers for breast cancer diagnosis and prognosis" -circulation_biomarker_prognosis_down hsa-mir-151a "Carcinoma, Breast" 30109140 "postoperatively downregulated circulating miR-130b-5p, miR-151a-5p, miR-206, and miR-222-3p may be potential biomarkers for breast cancer diagnosis and prognosis" -circulation_biomarker_prognosis_down hsa-mir-206 "Carcinoma, Breast" 30109140 "postoperatively downregulated circulating miR-130b-5p, miR-151a-5p, miR-206, and miR-222-3p may be potential biomarkers for breast cancer diagnosis and prognosis" -circulation_biomarker_prognosis_down hsa-mir-222 "Carcinoma, Breast" 30109140 "postoperatively downregulated circulating miR-130b-5p, miR-151a-5p, miR-206, and miR-222-3p may be potential biomarkers for breast cancer diagnosis and prognosis" -circulation_biomarker_prognosis_down hsa-mir-146a "Leukemia, Myeloid, Acute" 30242879 "the high expression of hsa-miR-509 and hsa-miR-542 were independent poor prognostic factors, whereas that of hsa-miR-146a and hsa-miR-3667 had a trend to be favorable factors" -circulation_biomarker_prognosis_down hsa-mir-3667 "Leukemia, Myeloid, Acute" 30242879 "the high expression of hsa-miR-509 and hsa-miR-542 were independent poor prognostic factors, whereas that of hsa-miR-146a and hsa-miR-3667 had a trend to be favorable factors" -circulation_biomarker_prognosis_ns hsa-mir-1 Chronic Hepatitis C 21070682 "The main aim of this study was to evaluate the expression of several miRNAs (miR-1, miR-30, miR-128, miR-196, miR-296) in peripheral blood mononuclear cells (PBMCs) from healthy individuals after in vitro IFN-treatment and in PBMCs from patients with chronic hepatitis C (CHC) before and 12 hours after the first injection of pegylated IFN alpha" -circulation_biomarker_prognosis_ns hsa-mir-128 Chronic Hepatitis C 21070682 "The main aim of this study was to evaluate the expression of several miRNAs (miR-1, miR-30, miR-128, miR-196, miR-296) in peripheral blood mononuclear cells (PBMCs) from healthy individuals after in vitro IFN-treatment and in PBMCs from patients with chronic hepatitis C (CHC) before and 12 hours after the first injection of pegylated IFN alpha" -circulation_biomarker_prognosis_ns hsa-mir-196 Chronic Hepatitis C 21070682 "The main aim of this study was to evaluate the expression of several miRNAs (miR-1, miR-30, miR-128, miR-196, miR-296) in peripheral blood mononuclear cells (PBMCs) from healthy individuals after in vitro IFN-treatment and in PBMCs from patients with chronic hepatitis C (CHC) before and 12 hours after the first injection of pegylated IFN alpha" -circulation_biomarker_prognosis_ns hsa-mir-296 Chronic Hepatitis C 21070682 "The main aim of this study was to evaluate the expression of several miRNAs (miR-1, miR-30, miR-128, miR-196, miR-296) in peripheral blood mononuclear cells (PBMCs) from healthy individuals after in vitro IFN-treatment and in PBMCs from patients with chronic hepatitis C (CHC) before and 12 hours after the first injection of pegylated IFN alpha" -circulation_biomarker_prognosis_ns hsa-mir-30 Chronic Hepatitis C 21070682 "The main aim of this study was to evaluate the expression of several miRNAs (miR-1, miR-30, miR-128, miR-196, miR-296) in peripheral blood mononuclear cells (PBMCs) from healthy individuals after in vitro IFN-treatment and in PBMCs from patients with chronic hepatitis C (CHC) before and 12 hours after the first injection of pegylated IFN alpha" -circulation_biomarker_prognosis_ns hsa-mir-126 Vascular Disease [unspecific] 23386708 plasma;Aspirin treatment hampers the use of plasma microRNA-126 as a biomarker for the progression of vascular disease -circulation_biomarker_prognosis_ns hsa-mir-103 Prostate Neoplasms 24583788 Serum microRNA expression patterns that predict early treatment failure in prostate cancer patients. -circulation_biomarker_prognosis_ns hsa-mir-125b Prostate Neoplasms 24583788 Serum microRNA expression patterns that predict early treatment failure in prostate cancer patients. -circulation_biomarker_prognosis_ns hsa-mir-222 Prostate Neoplasms 24583788 Serum microRNA expression patterns that predict early treatment failure in prostate cancer patients. -circulation_biomarker_prognosis_ns hsa-mir-103 Colorectal Carcinoma 26271186 Variability in microRNA recovery from plasma: Comparison of five commercial kits. -circulation_biomarker_prognosis_ns hsa-mir-18a Colorectal Carcinoma 26271186 Variability in microRNA recovery from plasma: Comparison of five commercial kits. -circulation_biomarker_prognosis_ns hsa-mir-191 Colorectal Carcinoma 26271186 Variability in microRNA recovery from plasma: Comparison of five commercial kits. -circulation_biomarker_prognosis_ns hsa-mir-21 Colorectal Carcinoma 26271186 Variability in microRNA recovery from plasma: Comparison of five commercial kits. -circulation_biomarker_prognosis_ns hsa-mir-23a Colorectal Carcinoma 26271186 Variability in microRNA recovery from plasma: Comparison of five commercial kits. -circulation_biomarker_prognosis_ns hsa-mir-29a Colorectal Carcinoma 26271186 Variability in microRNA recovery from plasma: Comparison of five commercial kits. -circulation_biomarker_prognosis_ns hsa-mir-451 Colorectal Carcinoma 26271186 Variability in microRNA recovery from plasma: Comparison of five commercial kits. -circulation_biomarker_prognosis_ns hsa-mir-34a "Carcinoma, Breast" 28178621 Changes of serum miR34a expression during neoadjuvant chemotherapy predict the treatment response and prognosis in stage II/III breast cancer. -circulation_biomarker_prognosis_ns hsa-mir-22 Atherosclerosis 28301500 Circulating progenitor cells in hypertensive subjects: Effectiveness of a treatment with olmesartan in improving cell number and miR profile in addition to expected pharmacological effects. -circulation_biomarker_prognosis_ns hsa-mir-221 Atherosclerosis 28301500 Circulating progenitor cells in hypertensive subjects: Effectiveness of a treatment with olmesartan in improving cell number and miR profile in addition to expected pharmacological effects. -circulation_biomarker_prognosis_ns hsa-mir-222 Atherosclerosis 28301500 Circulating progenitor cells in hypertensive subjects: Effectiveness of a treatment with olmesartan in improving cell number and miR profile in addition to expected pharmacological effects. -circulation_biomarker_prognosis_ns hsa-mir-145 Chronic Hepatitis 28368488 Plasma MicroRNA Levels Are Associated With Hepatitis B e Antigen Status and Treatment Response in Chronic Hepatitis B Patients. -circulation_biomarker_prognosis_ns hsa-mir-126 Atherosclerosis 28785651 Circulating level of microRNA-126 may be a potential biomarker for recovery from smoking-related vascular damage in middle-aged habitual smokers. -circulation_biomarker_prognosis_ns hsa-mir-208 Viral Myocarditis 29916103 "Circulating MicroRNAs: a Potential Biomarker for Cardiac Damage, Inflammatory Response, and Left Ventricular Function Recovery in Pediatric Viral Myocarditis." -circulation_biomarker_prognosis_ns hsa-mir-21 Viral Myocarditis 29916103 "Circulating MicroRNAs: a Potential Biomarker for Cardiac Damage, Inflammatory Response, and Left Ventricular Function Recovery in Pediatric Viral Myocarditis." -circulation_biomarker_prognosis_ns hsa-mir-125b Chronic Hepatitis B 30344656 Baseline serum miR-125b levels predict virologic response to nucleos(t)ide analogue treatment in patients with HBeAg-positive chronic hepatitis B. -circulation_biomarker_prognosis_ns hsa-let-7a-1 Lung Neoplasms 16885332 let-7a-1 expression correlates with poor survival of lung cancer patients -circulation_biomarker_prognosis_ns hsa-let-7a-2 Lung Neoplasms 16885332 let-7a-1 expression correlates with poor survival of lung cancer patients -circulation_biomarker_prognosis_ns hsa-let-7a-3 Lung Neoplasms 16885332 let-7a-1 expression correlates with poor survival of lung cancer patients -circulation_biomarker_prognosis_ns hsa-let-7b Lung Neoplasms 16885332 let-7a-1 expression correlates with poor survival of lung cancer patients -circulation_biomarker_prognosis_ns hsa-let-7c Lung Neoplasms 16885332 let-7a-1 expression correlates with poor survival of lung cancer patients -circulation_biomarker_prognosis_ns hsa-let-7d Lung Neoplasms 16885332 let-7a-1 expression correlates with poor survival of lung cancer patients -circulation_biomarker_prognosis_ns hsa-let-7e Lung Neoplasms 16885332 let-7a-1 expression correlates with poor survival of lung cancer patients -circulation_biomarker_prognosis_ns hsa-let-7f-1 Lung Neoplasms 16885332 let-7a-1 expression correlates with poor survival of lung cancer patients -circulation_biomarker_prognosis_ns hsa-let-7f-2 Lung Neoplasms 16885332 let-7a-1 expression correlates with poor survival of lung cancer patients -circulation_biomarker_prognosis_ns hsa-let-7g Lung Neoplasms 16885332 let-7a-1 expression correlates with poor survival of lung cancer patients -circulation_biomarker_prognosis_ns hsa-let-7i Lung Neoplasms 16885332 let-7a-1 expression correlates with poor survival of lung cancer patients -circulation_biomarker_prognosis_ns hsa-mir-16 Leukemia 19195700 Prognostic value of miR-16 expression in childhood acute lymphoblastic leukemia relationships to normal and malignant lymphocyte proliferation. -circulation_biomarker_prognosis_ns hsa-mir-181a-2 "Leukemia, Lymphocytic, Chronic, B-Cell" 20487546 "miR-181a:Differential expression of the sulfatase SULF2 and of miR-29a, -181a, and -221 was also observed between resistant and sensitive patients before treatment" -circulation_biomarker_prognosis_ns hsa-mir-221 "Leukemia, Lymphocytic, Chronic, B-Cell" 20487546 "miR-221:Differential expression of the sulfatase SULF2 and of miR-29a, -181a, and -221 was also observed between resistant and sensitive patients before treatment" -circulation_biomarker_prognosis_ns hsa-mir-29a "Leukemia, Lymphocytic, Chronic, B-Cell" 20487546 "miR-29a:Differential expression of the sulfatase SULF2 and of miR-29a, -181a, and -221 was also observed between resistant and sensitive patients before treatment" -circulation_biomarker_prognosis_ns hsa-mir-92a-1 Leukemia 21182798 The miR-92a expression in leukemia cells could be a prognostic factor in ALL patients -circulation_biomarker_prognosis_ns hsa-mir-92a-2 Leukemia 21182798 The miR-92a expression in leukemia cells could be a prognostic factor in ALL patients -circulation_biomarker_prognosis_ns hsa-let-7a-1 Myelodysplastic Syndromes 21332710 dysregulated -circulation_biomarker_prognosis_ns hsa-let-7a-2 Myelodysplastic Syndromes 21332710 dysregulated -circulation_biomarker_prognosis_ns hsa-let-7a-3 Myelodysplastic Syndromes 21332710 dysregulated -circulation_biomarker_prognosis_ns hsa-let-7b Myelodysplastic Syndromes 21332710 dysregulated -circulation_biomarker_prognosis_ns hsa-let-7c Myelodysplastic Syndromes 21332710 dysregulated -circulation_biomarker_prognosis_ns hsa-let-7d Myelodysplastic Syndromes 21332710 dysregulated -circulation_biomarker_prognosis_ns hsa-let-7e Myelodysplastic Syndromes 21332710 dysregulated -circulation_biomarker_prognosis_ns hsa-let-7f-1 Myelodysplastic Syndromes 21332710 dysregulated -circulation_biomarker_prognosis_ns hsa-let-7f-2 Myelodysplastic Syndromes 21332710 dysregulated -circulation_biomarker_prognosis_ns hsa-let-7g Myelodysplastic Syndromes 21332710 dysregulated -circulation_biomarker_prognosis_ns hsa-let-7i Myelodysplastic Syndromes 21332710 dysregulated -circulation_biomarker_prognosis_ns hsa-mir-181a-1 Myelodysplastic Syndromes 21332710 dysregulated -circulation_biomarker_prognosis_ns hsa-mir-181a-2 Myelodysplastic Syndromes 21332710 dysregulated -circulation_biomarker_prognosis_ns hsa-mir-181b-2 Myelodysplastic Syndromes 21332710 dysregulated -circulation_biomarker_prognosis_ns hsa-mir-181c Myelodysplastic Syndromes 21332710 dysregulated -circulation_biomarker_prognosis_ns hsa-mir-181d Myelodysplastic Syndromes 21332710 dysregulated -circulation_biomarker_prognosis_ns hsa-let-7a-1 Ovarian Neoplasms 21571355 let-7a is a potential marker for selection of paclitaxel in ovarian cancer management. -circulation_biomarker_prognosis_ns hsa-mir-155 Leukemia 22209839 "These results support that miR-128, let-7b, miR-223 and miR181a have a diagnosis value in AL, while miR-181a and miR-155 are of great prognostic significance in AML." -circulation_biomarker_prognosis_ns hsa-mir-181a Leukemia 22209839 "These results support that miR-128, let-7b, miR-223 and miR181a have a diagnosis value in AL, while miR-181a and miR-155 are of great prognostic significance in AML." -circulation_biomarker_prognosis_ns hsa-mir-17 Gastric Neoplasms 22406928 The concentrations of plasma miR-17-5p/20a were significantly associated with the differentiation status and TNM stages of gastric cancer. Kaplan-Meier curve analysis revealed that high expression levels of miR-17-5p/20a were significantly correlated with poor overall survival. Cox regression analysis demonstrated that the level of plasma miR-20a was an independent risk predictor for prognosis. -circulation_biomarker_prognosis_ns hsa-mir-20a Gastric Neoplasms 22406928 The concentrations of plasma miR-17-5p/20a were significantly associated with the differentiation status and TNM stages of gastric cancer. Kaplan-Meier curve analysis revealed that high expression levels of miR-17-5p/20a were significantly correlated with poor overall survival. Cox regression analysis demonstrated that the level of plasma miR-20a was an independent risk predictor for prognosis. -circulation_biomarker_prognosis_ns hsa-mir-21 Esophageal Neoplasms 22519435 Circulating miR-21 and miR-375 could be reliable prognostic markers for ESCC. -circulation_biomarker_prognosis_ns hsa-mir-375 Esophageal Neoplasms 22519435 Circulating miR-21 and miR-375 could be reliable prognostic markers for ESCC. -circulation_biomarker_prognosis_ns hsa-mir-125b-1 "Carcinoma, Lung, Non-Small-Cell" 22806310 Circulating miR-125b is a novel biomarker for screening non-small-cell lung cancer and predicts poor prognosis. -circulation_biomarker_prognosis_ns hsa-mir-125b-2 "Carcinoma, Lung, Non-Small-Cell" 22806310 Circulating miR-125b is a novel biomarker for screening non-small-cell lung cancer and predicts poor prognosis. -circulation_biomarker_prognosis_ns hsa-mir-223 "Lymphoma, Large B-Cell, Diffuse" 22932402 "As a potential prognostic biomarker, overexpression of miR-223 correlates with a longer OS of patients with DLBCL (diffuse large B cell lymphoma)." -circulation_biomarker_prognosis_ns hsa-mir-150 "Lymphoma, B-Cell" 22936066 miR-155 and miR-150 expression levels were associated with progression-free survival . -circulation_biomarker_prognosis_ns hsa-mir-155 "Lymphoma, B-Cell" 22936066 miR-155 and miR-150 expression levels were associated with progression-free survival . -circulation_biomarker_prognosis_ns hsa-mir-133a-1 Myocardial Infarction 23137501 Relation of circulating MicroRNA-133a concentrations with myocardial damage and clinical prognosis in ST-elevation myocardial infarction -circulation_biomarker_prognosis_ns hsa-mir-133a-2 Myocardial Infarction 23137501 Relation of circulating MicroRNA-133a concentrations with myocardial damage and clinical prognosis in ST-elevation myocardial infarction -circulation_biomarker_prognosis_ns hsa-mir-15a Ischemia 23233752 MicroRNA-15a and MicroRNA-16 Impair Human Circulating Proangiogenic Cell Functions and Are Increased in the Proangiogenic Cells and Serum of Patients With Critical Limb Ischemia -circulation_biomarker_prognosis_ns hsa-mir-16-1 "Leukemia-Lymphoma, Adult T-Cell" 23260326 Micro-RNA-16 expression in paraffin-embedded specimen correlates with overall survival of T-lymphoblastic lymphoma/leukemia -circulation_biomarker_prognosis_ns hsa-mir-16-2 "Leukemia-Lymphoma, Adult T-Cell" 23260326 Micro-RNA-16 expression in paraffin-embedded specimen correlates with overall survival of T-lymphoblastic lymphoma/leukemia -circulation_biomarker_prognosis_ns hsa-mir-21 Osteosarcoma 23321165 Identification of Serum MicroRNA-21 as a Biomarker for Chemosensitivity and Prognosis in Human Osteosarcoma -circulation_biomarker_prognosis_ns hsa-mir-126 Cardiovascular Diseases [unspecific] 23391580 "Platelets, endothelium, and circulating microRNA-126 as a prognostic biomarker in cardiovascular diseases: per aspirin ad astra." -circulation_biomarker_prognosis_ns hsa-mir-16-1 "Carcinoma, Lung, Non-Small-Cell" 23774211 MiR-16 exhibited the most statistically significant association: high expression of miR-16 was associated with a significantly better survival -circulation_biomarker_prognosis_ns hsa-mir-22 "Carcinoma, Lung, Non-Small-Cell" 23794259 "Circulating miR-22, miR-24 and miR-34a as novel predictive biomarkers to pemetrexed-based chemotherapy in advanced non-small cell lung cancer." -circulation_biomarker_prognosis_ns hsa-mir-24 "Carcinoma, Lung, Non-Small-Cell" 23794259 "Circulating miR-22, miR-24 and miR-34a as novel predictive biomarkers to pemetrexed-based chemotherapy in advanced non-small cell lung cancer." -circulation_biomarker_prognosis_ns hsa-mir-34a "Carcinoma, Lung, Non-Small-Cell" 23794259 "Circulating miR-22, miR-24 and miR-34a as novel predictive biomarkers to pemetrexed-based chemotherapy in advanced non-small cell lung cancer." -circulation_biomarker_prognosis_ns hsa-let-7 Prostate Neoplasms 23798998 Distinct microRNA expression profile in prostate cancer patients with early clinical failure and the impact of let-7 as prognostic marker in high-risk prostate cancer. -circulation_biomarker_prognosis_ns hsa-mir-155 Idiopathic Pulmonary Fibrosis 23822889 "These findings suggest that serum miR-21 is associated with IPF and the degree of damage indicated by FVC and radiologic examinations could correlate with miR-21 and miR-155 expression in serum. From another perspective, our study confirmed serum miRNA can be stable and detectable in serum of patients with IPF,which could prove useful as it could be considered as a new biomarker in serum for diagnosis and assessment of prognosis of IPF in the future." -circulation_biomarker_prognosis_ns hsa-mir-21 Idiopathic Pulmonary Fibrosis 23822889 "These findings suggest that serum miR-21 is associated with IPF and the degree of damage indicated by FVC and radiologic examinations could correlate with miR-21 and miR-155 expression in serum. From another perspective, our study confirmed serum miRNA can be stable and detectable in serum of patients with IPF,which could prove useful as it could be considered as a new biomarker in serum for diagnosis and assessment of prognosis of IPF in the future." -circulation_biomarker_prognosis_ns hsa-mir-21 Central Nervous System Embryonal Tumor 23832112 Serum miR-21 is a diagnostic and prognostic marker of primary central nervous system lymphoma. -circulation_biomarker_prognosis_ns hsa-mir-200c "Carcinoma, Esophageal" 23838916 The serum level of miR-200c can be useful for predicting the response to chemotherapy and the prognosis of patients with esophageal cancer who receive neoadjuvant chemotherapy. -circulation_biomarker_prognosis_ns hsa-mir-21 Colorectal Carcinoma 23970420 "Our results suggest that circulating serum miR-21 is a promising prognostic tumour marker, and they highlight the potential clinical utility of miR-21 expression as a prognostic marker for CRC prognosis." -circulation_biomarker_prognosis_ns hsa-mir-100 Gastric Neoplasms 23975664 Prognostic role of microRNA polymorphisms in advanced gastric cancer: a translational study of the Arbeitsgemeinschaft Internistische Onkologie (AIO). -circulation_biomarker_prognosis_ns hsa-mir-200c Colorectal Carcinoma 23982750 Serum miR-200c is a novel prognostic and metastasis-predictive biomarker in patients with colorectal cancer. -circulation_biomarker_prognosis_ns hsa-mir-21 Neoplasms [unspecific] 24076132 "Our findings suggest that circulating miR-21 may not suitable to be a diagnostic biomarker, but it has a prognostic value in patients with cancer." -circulation_biomarker_prognosis_ns hsa-mir-149 Neoplasms [unspecific] 24180461 The regression analysis identified tumour stage and miR-31 and miR-149 expression as independently associated with tumour progression and tumour stage and miR-149 expression as independently associated with cancer-specific survival. -circulation_biomarker_prognosis_ns hsa-let-7f Ovarian Neoplasms 24223734 Our findings indicate that plasma miR-205 and let-7f are biomarkers for ovarian cancer detection that complement CA-125; let-7f may be predictive of ovarian cancer prognosis. -circulation_biomarker_prognosis_ns hsa-mir-31 "Adenocarcinoma, Pancreatic Ductal" 24289824 "In a cohort of 70 patients, the high expression of miR-21 (p=0.018, HR=2.610; 95% CI=1.179-5.777) and miR-31 (p=0.039, HR=2.735; 95% CI=1.317-6.426), the low expression of miR-375 (p=0.022, HR=2.337; 95% CI=1.431-5.066) were associated with poor overall survival following resection, independent of clinical covariates." -circulation_biomarker_prognosis_ns hsa-mir-130 Colorectal Carcinoma 24304648 Circulating microRNA expressions in colorectal cancer as predictors of response to chemotherapy. -circulation_biomarker_prognosis_ns hsa-mir-145 Colorectal Carcinoma 24304648 Circulating microRNA expressions in colorectal cancer as predictors of response to chemotherapy. -circulation_biomarker_prognosis_ns hsa-mir-20a Colorectal Carcinoma 24304648 Circulating microRNA expressions in colorectal cancer as predictors of response to chemotherapy. -circulation_biomarker_prognosis_ns hsa-mir-216 Colorectal Carcinoma 24304648 Circulating microRNA expressions in colorectal cancer as predictors of response to chemotherapy. -circulation_biomarker_prognosis_ns hsa-mir-372 Colorectal Carcinoma 24304648 Circulating microRNA expressions in colorectal cancer as predictors of response to chemotherapy. -circulation_biomarker_prognosis_ns hsa-mir-221 Neoplasms [unspecific] 24319365 Lack of significant association between plasma/serum miR-221 expression and poor survival of carcinoma: a meta analysis. -circulation_biomarker_prognosis_ns hsa-mir-223 Intestinal Schistosomiasis 24330517 This study suggested that the circulating miR-223 could serve as a potential new biomarker for the detection of schistosome infection and the assessment of the response to chemotherapy. -circulation_biomarker_prognosis_ns hsa-mir-223 "Squamous Cell Carcinoma, Esophageal" 24390317 "miR-25, miR-223, and miR-375 were abnormally expressed in ESCC tissues and sera. Serum miR-223 and miR-375 are potential prognostic biomarkers for ESCC." -circulation_biomarker_prognosis_ns hsa-mir-25 "Squamous Cell Carcinoma, Esophageal" 24390317 "miR-25, miR-223, and miR-375 were abnormally expressed in ESCC tissues and sera. Serum miR-223 and miR-375 are potential prognostic biomarkers for ESCC." -circulation_biomarker_prognosis_ns hsa-mir-375 "Squamous Cell Carcinoma, Esophageal" 24390317 "miR-25, miR-223, and miR-375 were abnormally expressed in ESCC tissues and sera. Serum miR-223 and miR-375 are potential prognostic biomarkers for ESCC." -circulation_biomarker_prognosis_ns hsa-mir-16 Lymphoma 24447552 Significance of microRNA-16 and bcl-2 expression in T lymphoblastic lymphoma/leukemia and its relation with prognosis. -circulation_biomarker_prognosis_ns hsa-mir-19a Colorectal Carcinoma 24460313 Serum miR-19a predicts resistance to FOLFOX chemotherapy in advanced colorectal cancer cases. -circulation_biomarker_prognosis_ns hsa-mir-21 Gastric Neoplasms 24460332 Plasma post-operative miR-21 expression in the prognosis of gastric cancers. -circulation_biomarker_prognosis_ns hsa-mir-499 Myocardial Infarction 24461971 Admission levels of circulating miR-499-5p and risk of death in elderly patients after acute non-ST elevation myocardial infarction. -circulation_biomarker_prognosis_ns hsa-mir-146a "Carcinoma, Lung, Non-Small-Cell" 24531034 Serum levels of miR-19b and miR-146a as prognostic biomarkers for non-small cell lung cancer. -circulation_biomarker_prognosis_ns hsa-mir-19b "Carcinoma, Lung, Non-Small-Cell" 24531034 Serum levels of miR-19b and miR-146a as prognostic biomarkers for non-small cell lung cancer. -circulation_biomarker_prognosis_ns hsa-mir-103 "Carcinoma, Nasopharyngeal" 24563490 Differentially expressed plasma miRNAs as identified by next-generation sequencing can be helpful for predicting survival in NPC patients. -circulation_biomarker_prognosis_ns hsa-mir-29a "Carcinoma, Nasopharyngeal" 24563490 Differentially expressed plasma miRNAs as identified by next-generation sequencing can be helpful for predicting survival in NPC patients. -circulation_biomarker_prognosis_ns hsa-mir-483 "Carcinoma, Nasopharyngeal" 24563490 Differentially expressed plasma miRNAs as identified by next-generation sequencing can be helpful for predicting survival in NPC patients. -circulation_biomarker_prognosis_ns hsa-mir-21 Neoplasms [unspecific] 24664585 The present meta-analysis suggests that circulating miR-21 expression is associated with poor survival in patients with cancer and could be a prognostic biomarker for those patients. -circulation_biomarker_prognosis_ns hsa-mir-1236 "Lymphoma, Large B-Cell, Diffuse" 24858372 novel prognostic biomarkers to predict the clinical outcome of DLBCL patients treated with R-CHOP regimen. -circulation_biomarker_prognosis_ns hsa-mir-224 "Lymphoma, Large B-Cell, Diffuse" 24858372 novel prognostic biomarkers to predict the clinical outcome of DLBCL patients treated with R-CHOP regimen. -circulation_biomarker_prognosis_ns hsa-mir-33a "Lymphoma, Large B-Cell, Diffuse" 24858372 novel prognostic biomarkers to predict the clinical outcome of DLBCL patients treated with R-CHOP regimen. -circulation_biomarker_prognosis_ns hsa-mir-455 "Lymphoma, Large B-Cell, Diffuse" 24858372 novel prognostic biomarkers to predict the clinical outcome of DLBCL patients treated with R-CHOP regimen. -circulation_biomarker_prognosis_ns hsa-mir-520d "Lymphoma, Large B-Cell, Diffuse" 24858372 novel prognostic biomarkers to predict the clinical outcome of DLBCL patients treated with R-CHOP regimen. -circulation_biomarker_prognosis_ns hsa-let-7c Breast Neoplasms 24866763 "Our identified mRNAs and microRNAs were validated as prognostic factors of BC disease progression, and could potentially facilitate the implementation of assays for laboratory validation, due to their reduced number." -circulation_biomarker_prognosis_ns hsa-mir-139 Breast Neoplasms 24866763 "Our identified mRNAs and microRNAs were validated as prognostic factors of BC disease progression, and could potentially facilitate the implementation of assays for laboratory validation, due to their reduced number." -circulation_biomarker_prognosis_ns hsa-mir-320d Breast Neoplasms 24866763 "Our identified mRNAs and microRNAs were validated as prognostic factors of BC disease progression, and could potentially facilitate the implementation of assays for laboratory validation, due to their reduced number." -circulation_biomarker_prognosis_ns hsa-mir-567 Breast Neoplasms 24866763 "Our identified mRNAs and microRNAs were validated as prognostic factors of BC disease progression, and could potentially facilitate the implementation of assays for laboratory validation, due to their reduced number." -circulation_biomarker_prognosis_ns hsa-mir-29a "Carcinoma, Lung, Non-Small-Cell" 24928469 "Ten miRNA's were significantly associated with OS, with hsa-miR-29a being the strongest prognostic marker (HR=6.44, 95%-CI 2.39-17.33)." -circulation_biomarker_prognosis_ns hsa-mir-376a "Carcinoma, Lung, Non-Small-Cell" 24928469 "Six out of the 10 miRNA's (hsa-miRN-29a, hsa-miR-542-5p, hsa-miR-502-3p, hsa-miR-376a, hsa-miR-500a, hsa-miR-424) were insensitive to perturbations according to jackknife cross-validation on their HR for OS." -circulation_biomarker_prognosis_ns hsa-mir-424 "Carcinoma, Lung, Non-Small-Cell" 24928469 "Six out of the 10 miRNA's (hsa-miRN-29a, hsa-miR-542-5p, hsa-miR-502-3p, hsa-miR-376a, hsa-miR-500a, hsa-miR-424) were insensitive to perturbations according to jackknife cross-validation on their HR for OS." -circulation_biomarker_prognosis_ns hsa-mir-500a "Carcinoma, Lung, Non-Small-Cell" 24928469 "Six out of the 10 miRNA's (hsa-miRN-29a, hsa-miR-542-5p, hsa-miR-502-3p, hsa-miR-376a, hsa-miR-500a, hsa-miR-424) were insensitive to perturbations according to jackknife cross-validation on their HR for OS." -circulation_biomarker_prognosis_ns hsa-mir-502 "Carcinoma, Lung, Non-Small-Cell" 24928469 "Six out of the 10 miRNA's (hsa-miRN-29a, hsa-miR-542-5p, hsa-miR-502-3p, hsa-miR-376a, hsa-miR-500a, hsa-miR-424) were insensitive to perturbations according to jackknife cross-validation on their HR for OS." -circulation_biomarker_prognosis_ns hsa-mir-542 "Carcinoma, Lung, Non-Small-Cell" 24928469 "Six out of the 10 miRNA's (hsa-miRN-29a, hsa-miR-542-5p, hsa-miR-502-3p, hsa-miR-376a, hsa-miR-500a, hsa-miR-424) were insensitive to perturbations according to jackknife cross-validation on their HR for OS." -circulation_biomarker_prognosis_ns hsa-mir-210 "Carcinoma, Hepatocellular" 24935355 Serum miR-210 may represent a novel biomarker for predicting efficacy of transarterial chemoembolization and overall survival for patients with HCC. -circulation_biomarker_prognosis_ns hsa-let-7a Diabetes Mellitus 24937531 "Treatment-na?ve, poorly controlled diabetic patients show a significant dysregulation of miRNAs involved in the regulation of the adiponectin pathway, a phenomenon that may be reversed, at least in part, by improved glycemic control." -circulation_biomarker_prognosis_ns hsa-mir-143 Colorectal Carcinoma 24940606 We identified miR-345 in whole blood as a potential biomarker for clinical outcome. MiR-345 was a single prognostic biomarker for both OS and PFS in all patients and also in the non-KRAS mutant population. -circulation_biomarker_prognosis_ns hsa-mir-324 Colorectal Carcinoma 24940606 We identified miR-345 in whole blood as a potential biomarker for clinical outcome. MiR-345 was a single prognostic biomarker for both OS and PFS in all patients and also in the non-KRAS mutant population. -circulation_biomarker_prognosis_ns hsa-mir-345 Colorectal Carcinoma 24940606 We identified miR-345 in whole blood as a potential biomarker for clinical outcome. MiR-345 was a single prognostic biomarker for both OS and PFS in all patients and also in the non-KRAS mutant population. -circulation_biomarker_prognosis_ns hsa-mir-34a Colorectal Carcinoma 24940606 We identified miR-345 in whole blood as a potential biomarker for clinical outcome. MiR-345 was a single prognostic biomarker for both OS and PFS in all patients and also in the non-KRAS mutant population. -circulation_biomarker_prognosis_ns hsa-mir-628 Colorectal Carcinoma 24940606 We identified miR-345 in whole blood as a potential biomarker for clinical outcome. MiR-345 was a single prognostic biomarker for both OS and PFS in all patients and also in the non-KRAS mutant population. -circulation_biomarker_prognosis_ns hsa-mir-886 Colorectal Carcinoma 24940606 We identified miR-345 in whole blood as a potential biomarker for clinical outcome. MiR-345 was a single prognostic biomarker for both OS and PFS in all patients and also in the non-KRAS mutant population. -circulation_biomarker_prognosis_ns hsa-mir-218 Gastric Neoplasms 24944481 "miR-218 is deregulated in gastric cancer patients and is strongly correlated with tumor stage, grade and metastasis. Serum expression of miR-218 may be a prognostic marker." -circulation_biomarker_prognosis_ns hsa-mir-105 Pelvic Inflammatory Disease 24961692 Early microRNA expression profile as a prognostic biomarker for the development of pelvic inflammatory disease in a mouse model of chlamydial genital infection. -circulation_biomarker_prognosis_ns hsa-mir-132 Pelvic Inflammatory Disease 24961692 Early microRNA expression profile as a prognostic biomarker for the development of pelvic inflammatory disease in a mouse model of chlamydial genital infection. -circulation_biomarker_prognosis_ns hsa-mir-135a Pelvic Inflammatory Disease 24961692 Early microRNA expression profile as a prognostic biomarker for the development of pelvic inflammatory disease in a mouse model of chlamydial genital infection. -circulation_biomarker_prognosis_ns hsa-mir-142 Pelvic Inflammatory Disease 24961692 Early microRNA expression profile as a prognostic biomarker for the development of pelvic inflammatory disease in a mouse model of chlamydial genital infection. -circulation_biomarker_prognosis_ns hsa-mir-147 Pelvic Inflammatory Disease 24961692 Early microRNA expression profile as a prognostic biomarker for the development of pelvic inflammatory disease in a mouse model of chlamydial genital infection. -circulation_biomarker_prognosis_ns hsa-mir-155 Pelvic Inflammatory Disease 24961692 Early microRNA expression profile as a prognostic biomarker for the development of pelvic inflammatory disease in a mouse model of chlamydial genital infection. -circulation_biomarker_prognosis_ns hsa-mir-223 Pelvic Inflammatory Disease 24961692 Early microRNA expression profile as a prognostic biomarker for the development of pelvic inflammatory disease in a mouse model of chlamydial genital infection. -circulation_biomarker_prognosis_ns hsa-mir-298 Pelvic Inflammatory Disease 24961692 Early microRNA expression profile as a prognostic biomarker for the development of pelvic inflammatory disease in a mouse model of chlamydial genital infection. -circulation_biomarker_prognosis_ns hsa-mir-299a Pelvic Inflammatory Disease 24961692 Early microRNA expression profile as a prognostic biomarker for the development of pelvic inflammatory disease in a mouse model of chlamydial genital infection. -circulation_biomarker_prognosis_ns hsa-mir-325 Pelvic Inflammatory Disease 24961692 Early microRNA expression profile as a prognostic biomarker for the development of pelvic inflammatory disease in a mouse model of chlamydial genital infection. -circulation_biomarker_prognosis_ns hsa-mir-410 Pelvic Inflammatory Disease 24961692 Early microRNA expression profile as a prognostic biomarker for the development of pelvic inflammatory disease in a mouse model of chlamydial genital infection. -circulation_biomarker_prognosis_ns hsa-mir-202 Breast Neoplasms 24983365 "Based on their cancer-specific increase in breast cancer patients,circulating MAGE-A and BORIS mRNAs may be further explored for early detection of breast cancer and monitoring of MAGE-directed immunotherapies. Moreover, serum miR-202 is associated with prognosis." -circulation_biomarker_prognosis_ns hsa-mir-224 "Lymphoma, Large B-Cell, Diffuse" 25052605 miR-224 expression may play an important role in the development and progression of DLBCL and could be prognostic significance. -circulation_biomarker_prognosis_ns hsa-mir-21 Breast Neoplasms 25086636 "Changes in serum levels of miR-21, miR-210, and miR-373 in HER2-positive breast cancer patients undergoing neoadjuvant therapy" -circulation_biomarker_prognosis_ns hsa-mir-210 Breast Neoplasms 25086636 "Changes in serum levels of miR-21, miR-210, and miR-373 in HER2-positive breast cancer patients undergoing neoadjuvant therapy" -circulation_biomarker_prognosis_ns hsa-mir-373 Breast Neoplasms 25086636 "Changes in serum levels of miR-21, miR-210, and miR-373 in HER2-positive breast cancer patients undergoing neoadjuvant therapy" -circulation_biomarker_prognosis_ns hsa-mir-133b Osteosarcoma 25120799 Serum levels of microRNA-133b and microRNA-206 expression predict prognosis in patients with osteosarcoma. -circulation_biomarker_prognosis_ns hsa-mir-206 Osteosarcoma 25120799 Serum levels of microRNA-133b and microRNA-206 expression predict prognosis in patients with osteosarcoma. -circulation_biomarker_prognosis_ns hsa-mir-19a Breast Neoplasms 25137071 The combination of miR-19a and miR-205 in the serum may predict the chemosensitivity of luminal A subtype of breast cancer to epirubicin plus paclitaxel neoadjuvant chemotherapy. -circulation_biomarker_prognosis_ns hsa-mir-205 Breast Neoplasms 25137071 The combination of miR-19a and miR-205 in the serum may predict the chemosensitivity of luminal A subtype of breast cancer to epirubicin plus paclitaxel neoadjuvant chemotherapy. -circulation_biomarker_prognosis_ns hsa-mir-146a "Leukemia, Promyelocytic, Acute" 25161335 These findings indicated that miR-146a played an important role in the development of APL in part through the repression on Smad4 protein expression. miR-146a functioned as an oncogene and may be a novel prognostic biomarker in APL. -circulation_biomarker_prognosis_ns hsa-mir-454 Glioma 25190548 Plasma miR-454-3p as a potential prognostic indicator in human glioma. -circulation_biomarker_prognosis_ns hsa-mir-145 "Adenocarcinoma, Lung" 25192889 miRNA-145 is strongly associated with overall survival -circulation_biomarker_prognosis_ns hsa-mir-21 Glioma 25279461 "Moreover, in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses" -circulation_biomarker_prognosis_ns hsa-mir-10b Breast Neoplasms 25369070 "Moreover, miR-10b, miR-21 and miR-182 were significantly associated to lymph node metastases occurrence in triple negative breast carcinoma while only miR-10b was associated with grade III in non triple negative breast cancer cases." -circulation_biomarker_prognosis_ns hsa-mir-182 Breast Neoplasms 25369070 "Moreover, miR-10b, miR-21 and miR-182 were significantly associated to lymph node metastases occurrence in triple negative breast carcinoma" -circulation_biomarker_prognosis_ns hsa-mir-221 Lymphoma 25430553 serum miR-221 expression level has prognostic value in patients with CMM. -circulation_biomarker_prognosis_ns hsa-mir-155 Colorectal Carcinoma 25528214 the detection of miR-155 levels in the serum might serve as a new tumor biomarker in the diagnosis and assessment of prognosis of CRC. -circulation_biomarker_prognosis_ns hsa-mir-15a Glioma 25575767 "the expression of miR-15a is significantly correlated with prognosis in glioma patients, suggesting that the miR-15a may serve as independent prognostic marker." -circulation_biomarker_prognosis_ns hsa-mir-718 "Carcinoma, Hepatocellular" 25584485 Circulating miRs in serum exosomes have potential as novel biomarkers for predicting HCC recurrence. -circulation_biomarker_prognosis_ns hsa-mir-150 "Leukemia, Lymphocytic, Chronic, B-Cell" 25584781 Cellular and serum levels of miR-150 are associated with opposite clinical prognoses and could be used to molecularly monitor disease evolution as a new prognostic factor in CLL. -circulation_biomarker_prognosis_ns hsa-mir-224 Graves Ophthalmopathy 25588771 baseline serum miR-224-5p was associated with GC sensitivity in GO and in vitro overexpression of miR-224-5p restored GC sensitivity in a resistant cell model. A parameter combined serum miR-224-5p and TRAb could effectively predict GC ensitivity in GO patients. -circulation_biomarker_prognosis_ns hsa-mir-106b Breast Neoplasms 25619461 "MiR-106b was found to be associated with a high risk of recurrence of breast cancer, and miR-106b is a putative plasma marker for risk assessment in patients with breast cancer." -circulation_biomarker_prognosis_ns hsa-mir-141 Ovarian Neoplasms 25636451 miR-200c and miR-141 may be predictive biomarkers for ovarian cancer prognosis. Further large-scale studies are still needed to confirm our findings. -circulation_biomarker_prognosis_ns hsa-mir-200c Ovarian Neoplasms 25636451 miR-200c and miR-141 may be predictive biomarkers for ovarian cancer prognosis. Further large-scale studies are still needed to confirm our findings. -circulation_biomarker_prognosis_ns hsa-mir-128-2 "Carcinoma, Hepatocellular" 25642945 Serum miR-128-2 serves as a prognostic marker for patients with hepatocellular carcinoma. -circulation_biomarker_prognosis_ns hsa-let-7i Colorectal Carcinoma 25663689 We discovered a metastasis-specific miRNA signature in pCRCs and discovered novel tissue- and serum-based CRC metastasis-specific miRNA biomarkers through intensive validation. These unique miRNAs may be clinically applicable to predict prognosis and distant metastasis in CRC. -circulation_biomarker_prognosis_ns hsa-mir-10b Colorectal Carcinoma 25663689 We discovered a metastasis-specific miRNA signature in pCRCs and discovered novel tissue- and serum-based CRC metastasis-specific miRNA biomarkers through intensive validation. These unique miRNAs may be clinically applicable to predict prognosis and distant metastasis in CRC. -circulation_biomarker_prognosis_ns hsa-mir-221 Colorectal Carcinoma 25663689 We discovered a metastasis-specific miRNA signature in pCRCs and discovered novel tissue- and serum-based CRC metastasis-specific miRNA biomarkers through intensive validation. These unique miRNAs may be clinically applicable to predict prognosis and distant metastasis in CRC. -circulation_biomarker_prognosis_ns hsa-mir-320a Colorectal Carcinoma 25663689 We discovered a metastasis-specific miRNA signature in pCRCs and discovered novel tissue- and serum-based CRC metastasis-specific miRNA biomarkers through intensive validation. These unique miRNAs may be clinically applicable to predict prognosis and distant metastasis in CRC. -circulation_biomarker_prognosis_ns hsa-mir-885 Colorectal Carcinoma 25663689 We discovered a metastasis-specific miRNA signature in pCRCs and discovered novel tissue- and serum-based CRC metastasis-specific miRNA biomarkers through intensive validation. These unique miRNAs may be clinically applicable to predict prognosis and distant metastasis in CRC. -circulation_biomarker_prognosis_ns hsa-mir-122 Sepsis 25672224 Serum miR-122 correlates with short-term mortality in sepsis patients. -circulation_biomarker_prognosis_ns hsa-mir-224 "Carcinoma, Hepatocellular" 25688365 Serum miR-224 might be BCLC stage dependent. It can reflect the status of tumor and liver damage. It was an independent predictor for the survival of HCC patients. -circulation_biomarker_prognosis_ns hsa-mir-214 "Lymphoma, Large B-Cell, Diffuse" 25723320 Comprehensive miRNA sequence analysis reveals survival differences in diffuse large B-cell lymphoma patients -circulation_biomarker_prognosis_ns hsa-mir-28 "Lymphoma, Large B-Cell, Diffuse" 25723320 Comprehensive miRNA sequence analysis reveals survival differences in diffuse large B-cell lymphoma patients -circulation_biomarker_prognosis_ns hsa-mir-339 "Lymphoma, Large B-Cell, Diffuse" 25723320 Comprehensive miRNA sequence analysis reveals survival differences in diffuse large B-cell lymphoma patients -circulation_biomarker_prognosis_ns hsa-mir-5586 "Lymphoma, Large B-Cell, Diffuse" 25723320 Comprehensive miRNA sequence analysis reveals survival differences in diffuse large B-cell lymphoma patients -circulation_biomarker_prognosis_ns hsa-mir-210 "Adenocarcinoma, Lung" 25733977 "Significant correlations were found between miR-210 expression and lymph node metastasis, late disease stages, and poor prognosis in patients with adenocarcinoma." -circulation_biomarker_prognosis_ns hsa-mir-210 Melanoma 25749524 A direct plasma assay of circulating microRNA-210 of hypoxia can identify early systemic metastasis recurrence in melanoma patients. -circulation_biomarker_prognosis_ns hsa-mir-122 Hepatitis C Virus Infection 25811198 The expression levels of miR-21 and miR-122 were significantly different between the SVR and NR groups. -circulation_biomarker_prognosis_ns hsa-mir-141 Breast Neoplasms 25885099 "Circulating miR-200c and miR-141 were deregulated in BC comparing with controls. Furthermore, miR-200c and miR-141 were independent prognostic factors and associated with distinct outcomes of BC patients." -circulation_biomarker_prognosis_ns hsa-mir-200c Breast Neoplasms 25885099 "Circulating miR-200c and miR-141 were deregulated in BC comparing with controls. Furthermore, miR-200c and miR-141 were independent prognostic factors and associated with distinct outcomes of BC patients." -circulation_biomarker_prognosis_ns hsa-mir-208a Breast Neoplasms 26046768 Circulating mir-208a fails as a biomarker of doxorubicin-induced cardiotoxicity in breast cancer patients. -circulation_biomarker_prognosis_ns hsa-mir-200a Ovarian Neoplasms 26063644 "Our findings suggest that miR-200a, miR-200b, and miR-200c overexpressions are associated with the aggressive tumor progression and be recognized as reliable markers to predict the prognosis and survival in EOC patients." -circulation_biomarker_prognosis_ns hsa-mir-200b Ovarian Neoplasms 26063644 "Our findings suggest that miR-200a, miR-200b, and miR-200c overexpressions are associated with the aggressive tumor progression and be recognized as reliable markers to predict the prognosis and survival in EOC patients." -circulation_biomarker_prognosis_ns hsa-mir-200c Ovarian Neoplasms 26063644 "Our findings suggest that miR-200a, miR-200b, and miR-200c overexpressions are associated with the aggressive tumor progression and be recognized as reliable markers to predict the prognosis and survival in EOC patients." -circulation_biomarker_prognosis_ns hsa-mir-21 Gastric Neoplasms 26063956 Circulating MicroRNA-21 Is a Potential Diagnostic Biomarker in Gastric Cancer. -circulation_biomarker_prognosis_ns hsa-mir-197 Lung Neoplasms 26078336 Especially hsa-miR-197 could be validated by qRT-PCR as prognostic marker. -circulation_biomarker_prognosis_ns hsa-mir-126 Intermittent Claudication 26116711 "Whole blood expression of pro-angiogenic microRNA-126 increased after maximal exercise in the PLA session, but treatment with NAC prevented this response." -circulation_biomarker_prognosis_ns hsa-mir-10 "Leukemia, Myeloid, Acute" 26134365 Serum level of miR-10-5p as a prognostic biomarker for acute myeloid leukemia. -circulation_biomarker_prognosis_ns hsa-mir-106a Colorectal Carcinoma 26250939 The present study reveals novel serum-miRNA-based biomarkers for monitoring tumor dynamics as well as for predicting disease recurrence in patients with stage II/III CRC. -circulation_biomarker_prognosis_ns hsa-mir-145 Colorectal Carcinoma 26250939 The present study reveals novel serum-miRNA-based biomarkers for monitoring tumor dynamics as well as for predicting disease recurrence in patients with stage II/III CRC. -circulation_biomarker_prognosis_ns hsa-mir-17 Colorectal Carcinoma 26250939 The present study reveals novel serum-miRNA-based biomarkers for monitoring tumor dynamics as well as for predicting disease recurrence in patients with stage II/III CRC. -circulation_biomarker_prognosis_ns hsa-mir-101 Pleural Mesothelioma 26262875 "In conclusion, we suggest that miRNA signature A is predictive of sarcomatoid histotype and of worse prognosis in MPM." -circulation_biomarker_prognosis_ns hsa-mir-191 Pleural Mesothelioma 26262875 "In conclusion, we suggest that miRNA signature A is predictive of sarcomatoid histotype and of worse prognosis in MPM." -circulation_biomarker_prognosis_ns hsa-mir-223 Pleural Mesothelioma 26262875 "In conclusion, we suggest that miRNA signature A is predictive of sarcomatoid histotype and of worse prognosis in MPM." -circulation_biomarker_prognosis_ns hsa-mir-25 Pleural Mesothelioma 26262875 "In conclusion, we suggest that miRNA signature A is predictive of sarcomatoid histotype and of worse prognosis in MPM." -circulation_biomarker_prognosis_ns hsa-mir-26b Pleural Mesothelioma 26262875 "In conclusion, we suggest that miRNA signature A is predictive of sarcomatoid histotype and of worse prognosis in MPM." -circulation_biomarker_prognosis_ns hsa-mir-29a Pleural Mesothelioma 26262875 "In conclusion, we suggest that miRNA signature A is predictive of sarcomatoid histotype and of worse prognosis in MPM." -circulation_biomarker_prognosis_ns hsa-mir-335 Pleural Mesothelioma 26262875 "In conclusion, we suggest that miRNA signature A is predictive of sarcomatoid histotype and of worse prognosis in MPM." -circulation_biomarker_prognosis_ns hsa-mir-433 Pleural Mesothelioma 26262875 "In conclusion, we suggest that miRNA signature A is predictive of sarcomatoid histotype and of worse prognosis in MPM." -circulation_biomarker_prognosis_ns hsa-mir-516 Pleural Mesothelioma 26262875 "In conclusion, we suggest that miRNA signature A is predictive of sarcomatoid histotype and of worse prognosis in MPM." -circulation_biomarker_prognosis_ns hsa-mir-224 Lymphoma 26301883 MiR-224 expression level is implicated as a prognostic marker for DLBCL patients treated with R-CHOP. -circulation_biomarker_prognosis_ns hsa-mir-124 Toxic Epidermal Necrolysis 26394757 "The serum miR-124 concentration can be used as a disease activity marker for severe drug eruptions, reflecting the severity of keratinocyte apoptosis." -circulation_biomarker_prognosis_ns hsa-mir-4728 Breast Neoplasms 26406406 MiR-4728-3p had better ability in distinguishing patients with different status of HER2 than miR-4728-5p. And plasma miR-4728-3p might act as a non-invasive biomarker in predicting HER2 status. -circulation_biomarker_prognosis_ns hsa-mir-200c Malignant Neoplasms [unspecific] 26556949 "Our findings indicated that, compared to their tissue counterparts, the expression level of miR-200c and miR-141 in peripheral blood may be more effective for monitoring cancer prognosis. High miR-141 expression was better at predicting tumor progression than survival for malignant tumors." -circulation_biomarker_prognosis_ns hsa-mir-122 Autoimmune Hepatitis 26575387 Alternations of miR-21 and miR-122 serum levels could reflect their putative roles in the mediation of inflammatory processes in AIH. -circulation_biomarker_prognosis_ns hsa-mir-21 Autoimmune Hepatitis 26575387 Alternations of miR-21 and miR-122 serum levels could reflect their putative roles in the mediation of inflammatory processes in AIH. -circulation_biomarker_prognosis_ns hsa-mir-200c Gastric Neoplasms 26662382 Serum miR-200c expression level as a prognostic biomarker for gastric cancer. -circulation_biomarker_prognosis_ns hsa-mir-15a Sepsis 26683209 The plasma levels of miRNA are altered in patients with severe sepsis complicated by shock and may offer prognostic value as well as insights into the mechanisms of endothelial dysfunction in sepsis. -circulation_biomarker_prognosis_ns hsa-mir-27a Sepsis 26683209 The plasma levels of miRNA are altered in patients with severe sepsis complicated by shock and may offer prognostic value as well as insights into the mechanisms of endothelial dysfunction in sepsis. -circulation_biomarker_prognosis_ns hsa-mir-16 "Squamous Cell Carcinoma, Esophageal" 26692950 the level of miR-16 in the patients with good outcome was significantly higher than that in the patients with poor outcome -circulation_biomarker_prognosis_ns hsa-mir-197 Coronary Artery Disease 26720041 Serum-derived circulating miRNA-197 and miRNA-223 were identified as predictors for cardiovascular death in a large patient cohort with CAD. These results reinforce the assumption that circulating miRNAs are promising biomarkers with prognostic value with respect to future cardiovascular events. -circulation_biomarker_prognosis_ns hsa-mir-223 Coronary Artery Disease 26720041 Serum-derived circulating miRNA-197 and miRNA-223 were identified as predictors for cardiovascular death in a large patient cohort with CAD. These results reinforce the assumption that circulating miRNAs are promising biomarkers with prognostic value with respect to future cardiovascular events. -circulation_biomarker_prognosis_ns hsa-mir-122 "Carcinoma, Hepatocellular" 27074850 "HCC and/or histological components of NASH affected serum miR-122 levels, independently." -circulation_biomarker_prognosis_ns hsa-mir-455 "Squamous Cell Carcinoma, Head and Neck" 27109697 "miR-193b-3p and miR-455-5p were positively associated with survival, and miR-92a-3p and miR-497-5p were negatively associated with survival in OPSCC." -circulation_biomarker_prognosis_ns hsa-let-7 Lung Neoplasms 27133539 Patients with a high level of baseline serum let-7 expression level had significantly better overall survival -circulation_biomarker_prognosis_ns hsa-let-7 Chronic Hepatitis C 27227815 reduced levels of let-7a/7c/7d-5p (let-7s) in plasma were correlated with advanced histological hepatic fibrosis stage -circulation_biomarker_prognosis_ns hsa-mir-29a Acquired Immunodeficiency Syndrome 27232693 the expression level of miR-29a was found to be inversely correlated with HIV viral load -circulation_biomarker_prognosis_ns hsa-mir-29a Human Immunodeficiency Virus Infection 27232693 the expression level of miR-29a was found to be inversely correlated with HIV viral load -circulation_biomarker_prognosis_ns hsa-mir-125b "Carcinoma, Hepatocellular" 27267832 serum miR-125b can serve as a biomarker to reliably predict microvascular invasion -circulation_biomarker_prognosis_ns hsa-mir-181d Pancreatic Neoplasms 27380024 serum miR-181d was significantly associated with the presence of metastasis in patients with PDA -circulation_biomarker_prognosis_ns hsa-mir-106b Ependymoma 27390862 "Three miRNAs were shown to efficiently differentiate between grade II and III ependymomas: miR-17-5p, miR-19a-3p, and miR-106b-5p." -circulation_biomarker_prognosis_ns hsa-mir-196a Gastric Neoplasms 27420607 "Taken together, we propose that circulating miR-196a/b serve as a more sensitive and specific novel biomarker than carbohydrate antigen 19-9 for GC monitor, diagnosis and prognosis." -circulation_biomarker_prognosis_ns hsa-mir-196b Gastric Neoplasms 27420607 "Taken together, we propose that circulating miR-196a/b serve as a more sensitive and specific novel biomarker than carbohydrate antigen 19-9 for GC monitor, diagnosis and prognosis." -circulation_biomarker_prognosis_ns hsa-mir-484 "Carcinoma, Thyroid, Follicular" 27473101 The best two-miRNA classifier (miR-484/miR-148b-3p) identified thyroid malignancy with a sensitivity of 89â€? and a specificity of 87â€?. -circulation_biomarker_prognosis_ns hsa-mir-1296 "Carcinoma, Colon" 27485175 "The expression signature of five miRNAs (miR-1296, miR-135b, miR-539, miR-572 and miR-185) was found to be prognostic [p = 1.28E-07, HR 8.4 (95 % CI: 3.81-18.52)] for DMFS" -circulation_biomarker_prognosis_ns hsa-mir-135b "Carcinoma, Colon" 27485175 "The expression signature of five miRNAs (miR-1296, miR-135b, miR-539, miR-572 and miR-185) was found to be prognostic [p = 1.28E-07, HR 8.4 (95 % CI: 3.81-18.52)] for DMFS." -circulation_biomarker_prognosis_ns hsa-mir-185 "Carcinoma, Colon" 27485175 "The expression signature of five miRNAs (miR-1296, miR-135b, miR-539, miR-572 and miR-185) was found to be prognostic [p = 1.28E-07, HR 8.4 (95 % CI: 3.81-18.52)] for DMFS." -circulation_biomarker_prognosis_ns hsa-mir-539 "Carcinoma, Colon" 27485175 "The expression signature of five miRNAs (miR-1296, miR-135b, miR-539, miR-572 and miR-185) was found to be prognostic [p = 1.28E-07, HR 8.4 (95 % CI: 3.81-18.52)] for DMFS." -circulation_biomarker_prognosis_ns hsa-mir-572 "Carcinoma, Colon" 27485175 "The expression signature of five miRNAs (miR-1296, miR-135b, miR-539, miR-572 and miR-185) was found to be prognostic [p = 1.28E-07, HR 8.4 (95 % CI: 3.81-18.52)] for DMFS." -circulation_biomarker_prognosis_ns hsa-mir-592 "Carcinoma, Colon" 27485175 The expression of miR-592 was significantly associated with the MMR status (p.adjusted <0.01). -circulation_biomarker_prognosis_ns hsa-mir-516a Breast Neoplasms 27528030 "Finally, we show that a combination of 2 miRNAs (miR-190b and miR-516a-5p) exhibiting altered expression in TamR cell lines were predictive of treatment outcome in a cohort of ER+ breast cancer patients receiving adjuvant tamoxifen mono-therapy." -circulation_biomarker_prognosis_ns hsa-mir-34a "Carcinoma, Breast" 27561942 Human serum miR-34a as an indicator of exposure to ionizing radiation. -circulation_biomarker_prognosis_ns hsa-mir-18a Retinoblastoma 27574784 "Downregulation of inhibitor of apoptosis proteins, tumor miRNA-18a, altered serum cytokines, and serum miRNA-18a levels were observed upon NCL-APT treatment" -circulation_biomarker_prognosis_ns hsa-mir-21 "Carcinoma, Breast" 27696295 Serum microRNA-21 expression as a prognostic and therapeutic biomarker for breast cancer patients. -circulation_biomarker_prognosis_ns hsa-mir-15b Multiple Sclerosis 27725128 "Effect of fingolimod treatment on circulating miR-15b, miR23a and miR-223 levels in patients with multiple sclerosis." -circulation_biomarker_prognosis_ns hsa-mir-223 Multiple Sclerosis 27725128 "Effect of fingolimod treatment on circulating miR-15b, miR23a and miR-223 levels in patients with multiple sclerosis." -circulation_biomarker_prognosis_ns hsa-mir-23a Multiple Sclerosis 27725128 "Effect of fingolimod treatment on circulating miR-15b, miR23a and miR-223 levels in patients with multiple sclerosis." -circulation_biomarker_prognosis_ns hsa-mir-6826 "Carcinoma, Colon" 27878288 MicroRNA-6826 and -6875 in plasma are valuable non?invasive biomarkers that predict the efficacy of vaccine treatment against metastatic colorectal cancer. -circulation_biomarker_prognosis_ns hsa-mir-6875 "Carcinoma, Colon" 27878288 MicroRNA-6826 and -6875 in plasma are valuable non?invasive biomarkers that predict the efficacy of vaccine treatment against metastatic colorectal cancer. -circulation_biomarker_prognosis_ns hsa-let-7i "Carcinoma, Breast" 27959953 Identification of MicroRNAs as Breast Cancer Prognosis Markers through the Cancer Genome Atlas. -circulation_biomarker_prognosis_ns hsa-mir-103a "Carcinoma, Breast" 27959953 Identification of MicroRNAs as Breast Cancer Prognosis Markers through the Cancer Genome Atlas. -circulation_biomarker_prognosis_ns hsa-mir-140 "Carcinoma, Breast" 27959953 Identification of MicroRNAs as Breast Cancer Prognosis Markers through the Cancer Genome Atlas. -circulation_biomarker_prognosis_ns hsa-mir-200c "Carcinoma, Breast" 27959953 Identification of MicroRNAs as Breast Cancer Prognosis Markers through the Cancer Genome Atlas. -circulation_biomarker_prognosis_ns hsa-mir-21 "Carcinoma, Breast" 27959953 Identification of MicroRNAs as Breast Cancer Prognosis Markers through the Cancer Genome Atlas. -circulation_biomarker_prognosis_ns hsa-mir-25 "Carcinoma, Breast" 27959953 Identification of MicroRNAs as Breast Cancer Prognosis Markers through the Cancer Genome Atlas. -circulation_biomarker_prognosis_ns hsa-mir-30a "Carcinoma, Breast" 27959953 Identification of MicroRNAs as Breast Cancer Prognosis Markers through the Cancer Genome Atlas. -circulation_biomarker_prognosis_ns hsa-mir-30c "Carcinoma, Breast" 27959953 Identification of MicroRNAs as Breast Cancer Prognosis Markers through the Cancer Genome Atlas. -circulation_biomarker_prognosis_ns hsa-mir-320a "Carcinoma, Breast" 27959953 Identification of MicroRNAs as Breast Cancer Prognosis Markers through the Cancer Genome Atlas. -circulation_biomarker_prognosis_ns hsa-mir-361 "Carcinoma, Breast" 27959953 Identification of MicroRNAs as Breast Cancer Prognosis Markers through the Cancer Genome Atlas. -circulation_biomarker_prognosis_ns hsa-mir-374b "Carcinoma, Breast" 27959953 Identification of MicroRNAs as Breast Cancer Prognosis Markers through the Cancer Genome Atlas. -circulation_biomarker_prognosis_ns hsa-mir-651 "Carcinoma, Breast" 27959953 Identification of MicroRNAs as Breast Cancer Prognosis Markers through the Cancer Genome Atlas. -circulation_biomarker_prognosis_ns hsa-mir-101 Heart Transplant Rejection 28125729 Association of Serum MiR-142-3p and MiR-101-3p Levels with Acute Cellular Rejection after Heart Transplantation. -circulation_biomarker_prognosis_ns hsa-mir-142 Heart Transplant Rejection 28125729 Association of Serum MiR-142-3p and MiR-101-3p Levels with Acute Cellular Rejection after Heart Transplantation. -circulation_biomarker_prognosis_ns hsa-mir-33a "Carcinoma, Lung, Non-Small-Cell" 28141816 Association of microRNA-33a Molecular Signature with Non-Small Cell Lung Cancer Diagnosis and Prognosis after Chemotherapy. -circulation_biomarker_prognosis_ns hsa-let-7b Multiple Myeloma 28213378 Prognostic role of circulating exosomal miRNAs in multiple myeloma. -circulation_biomarker_prognosis_ns hsa-mir-18a Multiple Myeloma 28213378 Prognostic role of circulating exosomal miRNAs in multiple myeloma. -circulation_biomarker_prognosis_ns hsa-mir-30d Heart Failure 28214846 Circulating miR-30d Predicts Survival in Patients with Acute Heart Failure. -circulation_biomarker_prognosis_ns hsa-mir-106a Glioblastoma 28284220 Serum microRNA profiling in patients with glioblastoma: a survival analysis. -circulation_biomarker_prognosis_ns hsa-mir-145 Glioblastoma 28284220 Serum microRNA profiling in patients with glioblastoma: a survival analysis. -circulation_biomarker_prognosis_ns hsa-mir-182 Glioblastoma 28284220 Serum microRNA profiling in patients with glioblastoma: a survival analysis. -circulation_biomarker_prognosis_ns hsa-mir-20a Glioblastoma 28284220 Serum microRNA profiling in patients with glioblastoma: a survival analysis. -circulation_biomarker_prognosis_ns hsa-mir-222 Glioblastoma 28284220 Serum microRNA profiling in patients with glioblastoma: a survival analysis. -circulation_biomarker_prognosis_ns hsa-mir-1274a "Carcinoma, Ovarian" 28293063 Evaluation of Prognostic and Predictive Significance of Circulating MicroRNAs in Ovarian Cancer Patients. -circulation_biomarker_prognosis_ns hsa-mir-141 "Carcinoma, Ovarian" 28293063 Evaluation of Prognostic and Predictive Significance of Circulating MicroRNAs in Ovarian Cancer Patients. -circulation_biomarker_prognosis_ns hsa-mir-200b "Carcinoma, Ovarian" 28293063 Evaluation of Prognostic and Predictive Significance of Circulating MicroRNAs in Ovarian Cancer Patients. -circulation_biomarker_prognosis_ns hsa-mir-200c "Carcinoma, Ovarian" 28293063 Evaluation of Prognostic and Predictive Significance of Circulating MicroRNAs in Ovarian Cancer Patients. -circulation_biomarker_prognosis_ns hsa-mir-200 Neoplasms [unspecific] 28321402 Prognostic Role of the MicroRNA-200 Family in Various Carcinomas: A Systematic Review and Meta-Analysis. -circulation_biomarker_prognosis_ns hsa-mir-192 "Carcinoma, Periampullary" 28351309 Plasma microRNA192 in combination with serum CA19-9 as non-invasive prognostic biomarker in periampullary carcinoma. -circulation_biomarker_prognosis_ns hsa-mir-122 "Lymphoma, Hodgkin" 28377796 Redox Regulating Enzymes and Connected MicroRNA Regulators Have Prognostic Value in Classical Hodgkin Lymphomas. -circulation_biomarker_prognosis_ns hsa-mir-144 "Lymphoma, Hodgkin" 28377796 Redox Regulating Enzymes and Connected MicroRNA Regulators Have Prognostic Value in Classical Hodgkin Lymphomas. -circulation_biomarker_prognosis_ns hsa-mir-212 "Lymphoma, Hodgkin" 28377796 Redox Regulating Enzymes and Connected MicroRNA Regulators Have Prognostic Value in Classical Hodgkin Lymphomas. -circulation_biomarker_prognosis_ns hsa-mir-23b "Lymphoma, Hodgkin" 28377796 Redox Regulating Enzymes and Connected MicroRNA Regulators Have Prognostic Value in Classical Hodgkin Lymphomas. -circulation_biomarker_prognosis_ns hsa-mir-510 "Lymphoma, Hodgkin" 28377796 Redox Regulating Enzymes and Connected MicroRNA Regulators Have Prognostic Value in Classical Hodgkin Lymphomas. -circulation_biomarker_prognosis_ns hsa-mir-122 Chronic Hepatitis C 28401565 Serum and exosomal miR-122 and miR-199a as a biomarker to predict therapeutic efficacy of hepatitis C patients. -circulation_biomarker_prognosis_ns hsa-mir-199a Chronic Hepatitis C 28401565 Serum and exosomal miR-122 and miR-199a as a biomarker to predict therapeutic efficacy of hepatitis C patients. -circulation_biomarker_prognosis_ns hsa-mir-1 Atrial Fibrillation 28422282 "Analysis of Circulating miR-1, miR-23a, and miR-26a in Atrial Fibrillation Patients Undergoing Coronary Bypass Artery Grafting Surgery." -circulation_biomarker_prognosis_ns hsa-mir-23a Atrial Fibrillation 28422282 "Analysis of Circulating miR-1, miR-23a, and miR-26a in Atrial Fibrillation Patients Undergoing Coronary Bypass Artery Grafting Surgery." -circulation_biomarker_prognosis_ns hsa-mir-26a Atrial Fibrillation 28422282 "Analysis of Circulating miR-1, miR-23a, and miR-26a in Atrial Fibrillation Patients Undergoing Coronary Bypass Artery Grafting Surgery." -circulation_biomarker_prognosis_ns hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 28599250 Evaluation of MiR-15a and MiR-16-1 as prognostic biomarkers in chronic lymphocytic leukemia. -circulation_biomarker_prognosis_ns hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 28599250 Evaluation of MiR-15a and MiR-16-1 as prognostic biomarkers in chronic lymphocytic leukemia. -circulation_biomarker_prognosis_ns hsa-mir-21 Preeclampsia 28694210 Circulating microRNA expression as predictor of preeclampsia and its severity. -circulation_biomarker_prognosis_ns hsa-mir-125b "Carcinoma, Hepatocellular" 28814883 Serum exosomal miR-125b is a novel prognostic marker for hepatocellular carcinoma -circulation_biomarker_prognosis_ns hsa-mir-34a "Fatty Liver, Non-Alcoholic" 28853202 Potentially pro-apoptotic miR-34a was reduced in the vesicle-free fraction in serum but not in liver after UDCA treatment -circulation_biomarker_prognosis_ns hsa-mir-192 "Carcinoma, Urothelial" 28928837 "hsa-mir-7705, hsa-mir-192 and hsa-mir-518b can be applied as independent prognostic markers for bladder urothelial carcinoma" -circulation_biomarker_prognosis_ns hsa-mir-518b "Carcinoma, Urothelial" 28928837 "hsa-mir-7705, hsa-mir-192 and hsa-mir-518b can be applied as independent prognostic markers for bladder urothelial carcinoma" -circulation_biomarker_prognosis_ns hsa-mir-7705 "Carcinoma, Urothelial" 28928837 "hsa-mir-7705, hsa-mir-192 and hsa-mir-518b can be applied as independent prognostic markers for bladder urothelial carcinoma" -circulation_biomarker_prognosis_ns hsa-mir-181a "Leukemia, Myeloid, Acute" 29166738 Expression characteristics and prognosis significance of miRNA-181a in acute myeloid leukemia with normal karyotype -circulation_biomarker_prognosis_ns hsa-mir-122 "Carcinoma, Breast" 29243807 "some exosomal miRNAs including miR-126, miR-122, miR-92-1, miR-19a, and miR-29c together with circular miRNAs, such as miR-21-5p, miR-96-5p, and miR-125b-5p can provide a promising evaluation route in breast cancer prognosis" -circulation_biomarker_prognosis_ns hsa-mir-125b "Carcinoma, Breast" 29243807 "some exosomal miRNAs including miR-126, miR-122, miR-92-1, miR-19a, and miR-29c together with circular miRNAs, such as miR-21-5p, miR-96-5p, and miR-125b-5p can provide a promising evaluation route in breast cancer prognosis" -circulation_biomarker_prognosis_ns hsa-mir-126 "Carcinoma, Breast" 29243807 "some exosomal miRNAs including miR-126, miR-122, miR-92-1, miR-19a, and miR-29c together with circular miRNAs, such as miR-21-5p, miR-96-5p, and miR-125b-5p can provide a promising evaluation route in breast cancer prognosis" -circulation_biomarker_prognosis_ns hsa-mir-19a "Carcinoma, Breast" 29243807 "some exosomal miRNAs including miR-126, miR-122, miR-92-1, miR-19a, and miR-29c together with circular miRNAs, such as miR-21-5p, miR-96-5p, and miR-125b-5p can provide a promising evaluation route in breast cancer prognosis" -circulation_biomarker_prognosis_ns hsa-mir-21 "Carcinoma, Breast" 29243807 "some exosomal miRNAs including miR-126, miR-122, miR-92-1, miR-19a, and miR-29c together with circular miRNAs, such as miR-21-5p, miR-96-5p, and miR-125b-5p can provide a promising evaluation route in breast cancer prognosis" -circulation_biomarker_prognosis_ns hsa-mir-29c "Carcinoma, Breast" 29243807 "some exosomal miRNAs including miR-126, miR-122, miR-92-1, miR-19a, and miR-29c together with circular miRNAs, such as miR-21-5p, miR-96-5p, and miR-125b-5p can provide a promising evaluation route in breast cancer prognosis" -circulation_biomarker_prognosis_ns hsa-mir-92-1 "Carcinoma, Breast" 29243807 "some exosomal miRNAs including miR-126, miR-122, miR-92-1, miR-19a, and miR-29c together with circular miRNAs, such as miR-21-5p, miR-96-5p, and miR-125b-5p can provide a promising evaluation route in breast cancer prognosis" -circulation_biomarker_prognosis_ns hsa-mir-96 "Carcinoma, Breast" 29243807 "some exosomal miRNAs including miR-126, miR-122, miR-92-1, miR-19a, and miR-29c together with circular miRNAs, such as miR-21-5p, miR-96-5p, and miR-125b-5p can provide a promising evaluation route in breast cancer prognosis" -circulation_biomarker_prognosis_ns hsa-mir-148a "Carcinoma, Hepatocellular" 29291025 "tissue miR-9, miR-21, miR-22, miR-29c, miR-34a, miR-34c, miR-155, miR-199a, miR-200a, miR-203, miR-221 and blood miR-21, miR-148a, miR-192, miR-224 demonstrate significantly prognostic value" -circulation_biomarker_prognosis_ns hsa-mir-192 "Carcinoma, Hepatocellular" 29291025 "tissue miR-9, miR-21, miR-22, miR-29c, miR-34a, miR-34c, miR-155, miR-199a, miR-200a, miR-203, miR-221 and blood miR-21, miR-148a, miR-192, miR-224 demonstrate significantly prognostic value" -circulation_biomarker_prognosis_ns hsa-mir-21 "Carcinoma, Hepatocellular" 29291025 "tissue miR-9, miR-21, miR-22, miR-29c, miR-34a, miR-34c, miR-155, miR-199a, miR-200a, miR-203, miR-221 and blood miR-21, miR-148a, miR-192, miR-224 demonstrate significantly prognostic value" -circulation_biomarker_prognosis_ns hsa-mir-224 "Carcinoma, Hepatocellular" 29291025 "tissue miR-9, miR-21, miR-22, miR-29c, miR-34a, miR-34c, miR-155, miR-199a, miR-200a, miR-203, miR-221 and blood miR-21, miR-148a, miR-192, miR-224 demonstrate significantly prognostic value" -circulation_biomarker_prognosis_ns hsa-mir-16 "Carcinoma, Hepatocellular" 29333940 "Also, miR-16, miR-34a, and miR-221 serum levels would have a prognostic value" -circulation_biomarker_prognosis_ns hsa-mir-221 "Carcinoma, Hepatocellular" 29333940 "Also, miR-16, miR-34a, and miR-221 serum levels would have a prognostic value" -circulation_biomarker_prognosis_ns hsa-mir-34a "Carcinoma, Hepatocellular" 29333940 "Also, miR-16, miR-34a, and miR-221 serum levels would have a prognostic value" -circulation_biomarker_prognosis_ns hsa-mir-155 Leukemia 29654787 miR-155 might be a promising prognostic biomarker for this patient population -circulation_biomarker_prognosis_ns hsa-mir-126 Aplastic Anemia 29674506 "mir-126-5p, was negatively correlated with a response to therapy in aplastic anemia" -circulation_biomarker_prognosis_ns hsa-mir-215 Lung Neoplasms 29683761 "we identified a signature of seven microRNAs (miR-215-5p, miR-411-3p, miR-493-5p, miR-494-3p, miR-495-3p, miR-548j-5p and miR-93-3p) significantly associated with overall survival" -circulation_biomarker_prognosis_ns hsa-mir-411 Lung Neoplasms 29683761 "we identified a signature of seven microRNAs (miR-215-5p, miR-411-3p, miR-493-5p, miR-494-3p, miR-495-3p, miR-548j-5p and miR-93-3p) significantly associated with overall survival" -circulation_biomarker_prognosis_ns hsa-mir-493 Lung Neoplasms 29683761 "we identified a signature of seven microRNAs (miR-215-5p, miR-411-3p, miR-493-5p, miR-494-3p, miR-495-3p, miR-548j-5p and miR-93-3p) significantly associated with overall survival" -circulation_biomarker_prognosis_ns hsa-mir-494 Lung Neoplasms 29683761 "we identified a signature of seven microRNAs (miR-215-5p, miR-411-3p, miR-493-5p, miR-494-3p, miR-495-3p, miR-548j-5p and miR-93-3p) significantly associated with overall survival" -circulation_biomarker_prognosis_ns hsa-mir-495 Lung Neoplasms 29683761 "we identified a signature of seven microRNAs (miR-215-5p, miR-411-3p, miR-493-5p, miR-494-3p, miR-495-3p, miR-548j-5p and miR-93-3p) significantly associated with overall survival" -circulation_biomarker_prognosis_ns hsa-mir-548j Lung Neoplasms 29683761 "we identified a signature of seven microRNAs (miR-215-5p, miR-411-3p, miR-493-5p, miR-494-3p, miR-495-3p, miR-548j-5p and miR-93-3p) significantly associated with overall survival" -circulation_biomarker_prognosis_ns hsa-mir-93 Lung Neoplasms 29683761 "we identified a signature of seven microRNAs (miR-215-5p, miR-411-3p, miR-493-5p, miR-494-3p, miR-495-3p, miR-548j-5p and miR-93-3p) significantly associated with overall survival" -circulation_biomarker_prognosis_ns hsa-mir-3662 "Leukemia-Lymphoma, Adult T-Cell" 29684346 MicroRNA-3662 expression correlates with antiviral drug resistance in adult T-cell leukemia/lymphoma cells. -circulation_biomarker_prognosis_ns hsa-mir-142 Coronary Artery Disease 29891858 Plasma miR-142 predicts major adverse cardiovascular events as an intermediate biomarker of dual antiplatelet therapy. -circulation_biomarker_prognosis_ns hsa-mir-125b "Carcinoma, Pancreatic" 29913239 Plasma miR-125b-5p might act as an independent biomarker in predicting OS of PC patients -circulation_biomarker_prognosis_ns hsa-mir-21 Liver Cirrhosis 29935272 MicroRNA profiles in serum samples from patients with stable cirrhosis and miRNA-21 as a predictor of transplant-free survival. -circulation_biomarker_prognosis_ns hsa-mir-30a Myocardial Infarction 29959359 Circulating miR-30a-5p as a prognostic biomarker of left ventricular dysfunction after acute myocardial infarction. -circulation_biomarker_prognosis_ns hsa-mir-122 "Carcinoma, Hepatocellular" 30127924 Serum exosomal microRNA-122 and microRNA-21 as predictive biomarkers in transarterial chemoembolization-treated hepatocellular carcinoma patients. -circulation_biomarker_prognosis_ns hsa-mir-21 "Carcinoma, Hepatocellular" 30127924 Serum exosomal microRNA-122 and microRNA-21 as predictive biomarkers in transarterial chemoembolization-treated hepatocellular carcinoma patients. -circulation_biomarker_prognosis_ns hsa-mir-141 Colon Neoplasms 30138915 Prognostic Impact of miR-200 Family Members in Plasma and Exosomes from Tumor-Draining versus Peripheral Veins of Colon Cancer Patients. -circulation_biomarker_prognosis_ns hsa-mir-200a Colon Neoplasms 30138915 Prognostic Impact of miR-200 Family Members in Plasma and Exosomes from Tumor-Draining versus Peripheral Veins of Colon Cancer Patients. -circulation_biomarker_prognosis_ns hsa-mir-200b Colon Neoplasms 30138915 Prognostic Impact of miR-200 Family Members in Plasma and Exosomes from Tumor-Draining versus Peripheral Veins of Colon Cancer Patients. -circulation_biomarker_prognosis_ns hsa-mir-200c Colon Neoplasms 30138915 Prognostic Impact of miR-200 Family Members in Plasma and Exosomes from Tumor-Draining versus Peripheral Veins of Colon Cancer Patients. -circulation_biomarker_prognosis_ns hsa-mir-429 Colon Neoplasms 30138915 Prognostic Impact of miR-200 Family Members in Plasma and Exosomes from Tumor-Draining versus Peripheral Veins of Colon Cancer Patients. -circulation_biomarker_prognosis_ns hsa-mir-328 Colorectal Carcinoma 30166271 Serum-based microRNA signature predicts relapse and therapeutic outcome of adjuvant chemotherapy in colorectal cancer patients. -circulation_biomarker_prognosis_ns hsa-mir-342 Colorectal Carcinoma 30166271 Serum-based microRNA signature predicts relapse and therapeutic outcome of adjuvant chemotherapy in colorectal cancer patients. -circulation_biomarker_prognosis_ns hsa-mir-501 Colorectal Carcinoma 30166271 Serum-based microRNA signature predicts relapse and therapeutic outcome of adjuvant chemotherapy in colorectal cancer patients. -circulation_biomarker_prognosis_ns hsa-mir-652 Colorectal Carcinoma 30166271 Serum-based microRNA signature predicts relapse and therapeutic outcome of adjuvant chemotherapy in colorectal cancer patients. -circulation_biomarker_prognosis_ns hsa-mir-1202 Depression Disorder 30181751 "Serum-based microRNA biomarkers for major depression: MiR-16, miR-135a, and miR-1202." -circulation_biomarker_prognosis_ns hsa-mir-135a Depression Disorder 30181751 "Serum-based microRNA biomarkers for major depression: MiR-16, miR-135a, and miR-1202." -circulation_biomarker_prognosis_ns hsa-mir-16 Depression Disorder 30181751 "Serum-based microRNA biomarkers for major depression: MiR-16, miR-135a, and miR-1202." -circulation_biomarker_prognosis_ns hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 30190521 "combination of miR-1290, miR-196b and miR-135a in tumor tissue, and miR-21, miR-25, miR27b, and miR-326 in plasma were predictive for response to platinum-based chemotherapy in advanced NSCLC" -circulation_biomarker_prognosis_ns hsa-mir-25 "Carcinoma, Lung, Non-Small-Cell" 30190521 "combination of miR-1290, miR-196b and miR-135a in tumor tissue, and miR-21, miR-25, miR27b, and miR-326 in plasma were predictive for response to platinum-based chemotherapy in advanced NSCLC" -circulation_biomarker_prognosis_ns hsa-mir-27b "Carcinoma, Lung, Non-Small-Cell" 30190521 "combination of miR-1290, miR-196b and miR-135a in tumor tissue, and miR-21, miR-25, miR27b, and miR-326 in plasma were predictive for response to platinum-based chemotherapy in advanced NSCLC" -circulation_biomarker_prognosis_ns hsa-mir-326 "Carcinoma, Lung, Non-Small-Cell" 30190521 "combination of miR-1290, miR-196b and miR-135a in tumor tissue, and miR-21, miR-25, miR27b, and miR-326 in plasma were predictive for response to platinum-based chemotherapy in advanced NSCLC" -circulation_biomarker_prognosis_ns hsa-mir-125a "Leukemia, Lymphocytic, Chronic, B-Cell" 30242085 MiR-125a and MiR-34a expression predicts Richter syndrome in chronic lymphocytic leukemia patients. -circulation_biomarker_prognosis_ns hsa-mir-34a "Leukemia, Lymphocytic, Chronic, B-Cell" 30242085 MiR-125a and MiR-34a expression predicts Richter syndrome in chronic lymphocytic leukemia patients. -circulation_biomarker_prognosis_ns hsa-mir-21 "Adenocarcinoma, Pancreatic Ductal" 30336280 "Prognostic significance of circulating microRNA-21 expression in esophageal, pancreatic and colorectal cancers; a systematic review and meta-analysis." -circulation_biomarker_prognosis_ns hsa-mir-21 Colorectal Carcinoma 30336280 "Prognostic significance of circulating microRNA-21 expression in esophageal, pancreatic and colorectal cancers; a systematic review and meta-analysis." -circulation_biomarker_prognosis_ns hsa-mir-21 "Squamous Cell Carcinoma, Esophageal" 30336280 "Prognostic significance of circulating microRNA-21 expression in esophageal, pancreatic and colorectal cancers; a systematic review and meta-analysis." -circulation_biomarker_prognosis_ns hsa-mir-155 "Leukemia, Lymphoblastic, Acute" 30362157 miRNA-155 and miRNA-181a as prognostic biomarkers for pediatric acute lymphoblastic leukemia. -circulation_biomarker_prognosis_ns hsa-mir-181a "Leukemia, Lymphoblastic, Acute" 30362157 miRNA-155 and miRNA-181a as prognostic biomarkers for pediatric acute lymphoblastic leukemia. -circulation_biomarker_prognosis_up hsa-mir-29b Encephalitis 30196835 Increased serum microRNA-29b expression and bad recovery in Japanese encephalitis virus infected patients; A new component to improve the disease recovery. -circulation_biomarker_prognosis_up hsa-mir-155 Lung Neoplasms 17028302 A high expression of miR-155 has been suggested to be significantly associated with unfavorable prognosis in lung adenocarcinoma patients. -circulation_biomarker_prognosis_up hsa-mir-155 Lung Neoplasms 17028596 "High mir-155 associated with poor prognosis in lung cancer (Yanaihara et al., 2006)." -circulation_biomarker_prognosis_up hsa-mir-125b-1 Rectal Neoplasms 18695884 miR-125b: frequently upregulated in response to capecitabine chemoradiotherapy of rectal cancer -circulation_biomarker_prognosis_up hsa-mir-125b-2 Rectal Neoplasms 18695884 miR-125b: frequently upregulated in response to capecitabine chemoradiotherapy of rectal cancer -circulation_biomarker_prognosis_up hsa-mir-137 Rectal Neoplasms 18695884 miR-137: frequently upregulated in response to capecitabine chemoradiotherapy of rectal cancer -circulation_biomarker_prognosis_up hsa-mir-21 Breast Neoplasms 18812439 "miR-21: miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis" -circulation_biomarker_prognosis_up hsa-mir-211 "Carcinoma, Oral" 18946016 miR-211: Association between high miR-211 microRNA expression and the poor prognosis -circulation_biomarker_prognosis_up hsa-mir-155 Waldenstrom Macroglobulinemia 19074725 miR-155: increased expression -circulation_biomarker_prognosis_up hsa-mir-184 Waldenstrom Macroglobulinemia 19074725 miR-184: increased expression -circulation_biomarker_prognosis_up hsa-mir-206 Waldenstrom Macroglobulinemia 19074725 miR-206: increased expression -circulation_biomarker_prognosis_up hsa-mir-363 Waldenstrom Macroglobulinemia 19074725 miR-363*: increased expression -circulation_biomarker_prognosis_up hsa-mir-494 Waldenstrom Macroglobulinemia 19074725 miR-494: increased expression -circulation_biomarker_prognosis_up hsa-mir-542 Waldenstrom Macroglobulinemia 19074725 miR-542-3p: increased expression -circulation_biomarker_prognosis_up hsa-mir-21 Pancreatic Neoplasms 21139804 upregulated and correlated with worse survival -circulation_biomarker_prognosis_up hsa-mir-221 "Carcinoma, Hepatocellular" 21295551 "Serum miR-221, upregulated in HCC, can provide predictive significance for prognosis of HCC patients." -circulation_biomarker_prognosis_up hsa-mir-141 Colorectal Carcinoma 21445232 High levels of plasma miR-141 predicted poor survival in both cohorts and that miR-141 was an independent prognostic factor for advanced colon cancer. -circulation_biomarker_prognosis_up hsa-mir-200c Lung Neoplasms 21516486 High expression of serum miR-21 and tumor miR-200c associated with poor prognosis in patients with lung cancer -circulation_biomarker_prognosis_up hsa-mir-21 Lung Neoplasms 21516486 High expression of serum miR-21 and tumor miR-200c associated with poor prognosis in patients with lung cancer -circulation_biomarker_prognosis_up hsa-mir-663a "Leukemia, Myeloid, Acute" 21518431 Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663 -circulation_biomarker_prognosis_up hsa-mir-183 Lung Neoplasms 21920043 Expression levels of members of the miR-183 family in lung cancer tumor and sera were higher than that of their normal counterparts. The miR-96 expression in tumors was positively associated with its expression in sera. Log-rank and Cox regression analyses demonstrated that high expression of tumor and serum miRNAs of the miR-183 family were associated with overall poor survival in patients with lung cancer. -circulation_biomarker_prognosis_up hsa-mir-96 Lung Neoplasms 21920043 Expression levels of members of the miR-183 family in lung cancer tumor and sera were higher than that of their normal counterparts. The miR-96 expression in tumors was positively associated with its expression in sera. Log-rank and Cox regression analyses demonstrated that high expression of tumor and serum miRNAs of the miR-183 family were associated with overall poor survival in patients with lung cancer. -circulation_biomarker_prognosis_up hsa-mir-21 Lymphoma 22541087 The expression of miR-21 in plasma of lymphoma patient group significantly correlated with their serum LDH level. The expressions of miR-21 and miR-210 in plasma of previously untreated lymphoma patient group were higher than those of the patients treated for 6 or more courses -circulation_biomarker_prognosis_up hsa-mir-210 Lymphoma 22541087 The expression of miR-21 in plasma of lymphoma patient group significantly correlated with their serum LDH level. The expressions of miR-21 and miR-210 in plasma of previously untreated lymphoma patient group were higher than those of the patients treated for 6 or more courses -circulation_biomarker_prognosis_up hsa-let-7d Glioblastoma 22722712 "miR-181b, miR-153, miR-145, miR-137, and let-7d were significantly upregulated after treatment with both TMZ (temozolomide ) and OLE (Olea europaea leaf extract)." -circulation_biomarker_prognosis_up hsa-mir-155 Acute Myocardial Infarction 22995291 "Real-time RT-PCR confirmed that the serum levels of miR-155 and miR-380* were approximately 4- and 3-fold higher, respectively, in patients who experienced cardiac death within 1 year after discharge." -circulation_biomarker_prognosis_up hsa-mir-380 Acute Myocardial Infarction 22995291 "Real-time RT-PCR confirmed that the serum levels of miR-155 and miR-380* were approximately 4- and 3-fold higher, respectively, in patients who experienced cardiac death within 1 year after discharge." -circulation_biomarker_prognosis_up hsa-mir-100 "Leukemia, Myeloid, Acute" 23055746 Upregulation of microRNA-100 predicts poor prognosis in patients with pediatric acute myeloid leukemia -circulation_biomarker_prognosis_up hsa-mir-1 Heart Failure 23079087 Elevated plasma microRNA-1 predicts heart failure after acute myocardial infarction. -circulation_biomarker_prognosis_up hsa-mir-17 "Carcinoma, Hepatocellular" 23108086 High expression of serum miR-17-5p associated with poor prognosis in patients with hepatocellular carcinoma -circulation_biomarker_prognosis_up hsa-mir-200c "Lymphoma, Large B-Cell, Diffuse" 23232598 High expression of microRNA-200c predicts poor clinical outcome in diffuse large B-cell lymphoma -circulation_biomarker_prognosis_up hsa-mir-221 "Leukemia, Lymphoblastic, Acute" 23566596 Increased expression of miR-221 is associated with shorter overall survival in T-cell acute lymphoid leukemia -circulation_biomarker_prognosis_up hsa-mir-146b Prostate Neoplasms 23846169 Multivariate analysis revealed that miR-146b-3p possessed prognostic information beyond standard clinicopathological parameters. -circulation_biomarker_prognosis_up hsa-mir-194 Prostate Neoplasms 23846169 "Analysis of tissue cohorts revealed that miR-194 was robustly expressed in the prostate, elevated in metastases, and its expression in primary tumours was associated with a poor prognosis." -circulation_biomarker_prognosis_up hsa-mir-375 "Leukemia, Myeloid, Acute" 23864342 Upregulation of microRNA-375 is associated with poor prognosis in pediatric acute myeloid leukemia. -circulation_biomarker_prognosis_up hsa-mir-27a Neoplasms [unspecific] 24122958 miRNA27a is a biomarker for predicting chemosensitivity and prognosis in metastatic or recurrent gastric cancer. -circulation_biomarker_prognosis_up hsa-mir-221 "Carcinoma, Renal Cell" 24379138 Higher circulating expression levels of miR-221 associated with poor overall survival in renal cell carcinoma patients. -circulation_biomarker_prognosis_up hsa-mir-10b Breast Neoplasms 24416156 "High levels of miR-21 and miR-10b were present in the serum of patients with non-metastatic and metastatic HER2(+) breast cancer, respectively. High levels of serum miR-19a may represent a biomarker for IBC that is predictive for favorable clinical outcome in patients with metastatic HER2(+) IBC." -circulation_biomarker_prognosis_up hsa-mir-19a Breast Neoplasms 24416156 "High levels of miR-21 and miR-10b were present in the serum of patients with non-metastatic and metastatic HER2(+) breast cancer, respectively. High levels of serum miR-19a may represent a biomarker for IBC that is predictive for favorable clinical outcome in patients with metastatic HER2(+) IBC." -circulation_biomarker_prognosis_up hsa-mir-21 Breast Neoplasms 24416156 "High levels of miR-21 and miR-10b were present in the serum of patients with non-metastatic and metastatic HER2(+) breast cancer, respectively. High levels of serum miR-19a may represent a biomarker for IBC that is predictive for favorable clinical outcome in patients with metastatic HER2(+) IBC." -circulation_biomarker_prognosis_up hsa-mir-210 Aortic Stenosis 24626394 Circulating miR-210 levels are increased in patients with AS and provide independent prognostic information to established risk indices.Analytical characteristics were also excellent supporting the potential of micro-RNAs as novel CV biomarkers. -circulation_biomarker_prognosis_up hsa-mir-221 Prostate Neoplasms 24760272 Influence of peripheral whole-blood microRNA-7 and microRNA-221 high expression levels on the acquisition of castration-resistant prostate cancer: evidences from in vitro and in vivo studies. -circulation_biomarker_prognosis_up hsa-mir-7 Prostate Neoplasms 24760272 Influence of peripheral whole-blood microRNA-7 and microRNA-221 high expression levels on the acquisition of castration-resistant prostate cancer: evidences from in vitro and in vivo studies. -circulation_biomarker_prognosis_up hsa-mir-200c Neoplasms [unspecific] 24870778 Low expression of microRNA 200c in tumor tissue and high expression of microRNA 200c in serum are associated with worse survival in solid tumors. Further study is needed to elucidate this contradiction. -circulation_biomarker_prognosis_up hsa-mir-15b Melanoma 25155861 Serum miR-15b levels significantly increased over time in recurrent patients -circulation_biomarker_prognosis_up hsa-mir-21 Breast Neoplasms 25277099 "Women with metastatic breast cancer, especially CSII, presented up-regulated levels of miR-183, miR-494 and miR-21, which were associated with a poor prognosis." -circulation_biomarker_prognosis_up hsa-mir-221 "Carcinoma, Lung, Non-Small-Cell" 25466375 High serum miR-155 and miR-221 during the first 2 weeks of CRT were associated with the development of severe RIET -circulation_biomarker_prognosis_up hsa-mir-155 Breast Neoplasms 25503185 a possible involvement of miR-155 in surgery-induced angiogenesis and potential prognostic significance of high postoperative levels of circulating miR-195 in patients with breast cancer. -circulation_biomarker_prognosis_up hsa-mir-195 Breast Neoplasms 25503185 a possible involvement of miR-155 in surgery-induced angiogenesis and potential prognostic significance of high postoperative levels of circulating miR-195 in patients with breast cancer. -circulation_biomarker_prognosis_up hsa-mir-21 Breast Neoplasms 25503185 a possible involvement of miR-155 in surgery-induced angiogenesis and potential prognostic significance of high postoperative levels of circulating miR-195 in patients with breast cancer. -circulation_biomarker_prognosis_up hsa-mir-183 Colorectal Carcinoma 25629978 the elevated miR-183 in the plasma could be a promising biomarker for predicting the risk of tumor recurrence and poor survival in CRC patients. -circulation_biomarker_prognosis_up hsa-mir-122 "Carcinoma, Hepatocellular" 25636448 "high serum miR-122 level is independently associated with higher overall survival rate in hepatocellular carcinoma patients, and it is a good biomarker of better prognosis in patients with hepatocellular carcinoma." -circulation_biomarker_prognosis_up hsa-mir-24 "Leukemia, Acute" 25672522 High miR-24 expression is associated with risk of relapse and poor survival in acute leukemia. -circulation_biomarker_prognosis_up hsa-mir-18a "Squamous Cell Carcinoma, Head and Neck" 25677760 "significant elevated expressions of miR-21, miR-18a, miR-134a, miR-210, miR-181a, miR-19a, and miR-155 were associated with poor survival in human HNSCC." -circulation_biomarker_prognosis_up hsa-mir-18b Lymphoma 25736311 miR-18b overexpression identifies mantle cell lymphoma patients with poor outcome and improves the MIPI-B prognosticator. -circulation_biomarker_prognosis_up hsa-mir-183 Tuberculosis 25755759 High serum miR-183 level is associated with the bioactivity of macrophage derived from tuberculosis patients. -circulation_biomarker_prognosis_up hsa-mir-126 "Leukemia, Myeloid, Acute" 25759982 "The results of the present study demonstrated that higher expression levels of miR-126-5p/3p in patients with AML resulted in a poorer prognosis. Furthermore, miR-126-5p elevated the phosphorylation of Akt." -circulation_biomarker_prognosis_up hsa-mir-21 Brain Neoplasms 25790954 "microRNA-21 is associated with the prognosis of patients with brain tumors, and high expression of microRNA-21 can predict poor prognosis in patients with brain tumors." -circulation_biomarker_prognosis_up hsa-mir-206 Myotonic Muscular Dystrophy 25915631 "Specifically, miR-1, miR-133a, miR133b and miR-206 serum levels were found elevated in DM1 patients with progressive muscle wasting compared to disease stable DM1 patients." -circulation_biomarker_prognosis_up hsa-mir-155 Bladder Neoplasms 25918190 We found that elevated expression of miR-155 is correlated with a poor outcome for patients with bladder cancer; this suggests that miR-155 is a potential biomarker for bladder cancer prognosis. -circulation_biomarker_prognosis_up hsa-mir-17 Colorectal Carcinoma 26057451 Abundant expression of exosomal miR-19a in serum was identified as a prognostic biomarker for recurrence in CRC patients. -circulation_biomarker_prognosis_up hsa-mir-18 Colorectal Carcinoma 26057451 Abundant expression of exosomal miR-19a in serum was identified as a prognostic biomarker for recurrence in CRC patients. -circulation_biomarker_prognosis_up hsa-mir-19a Colorectal Carcinoma 26057451 Abundant expression of exosomal miR-19a in serum was identified as a prognostic biomarker for recurrence in CRC patients. -circulation_biomarker_prognosis_up hsa-mir-19b-1 Colorectal Carcinoma 26057451 Abundant expression of exosomal miR-19a in serum was identified as a prognostic biomarker for recurrence in CRC patients. -circulation_biomarker_prognosis_up hsa-mir-20a Colorectal Carcinoma 26057451 Abundant expression of exosomal miR-19a in serum was identified as a prognostic biomarker for recurrence in CRC patients. -circulation_biomarker_prognosis_up hsa-mir-92-1 Colorectal Carcinoma 26057451 Abundant expression of exosomal miR-19a in serum was identified as a prognostic biomarker for recurrence in CRC patients. -circulation_biomarker_prognosis_up hsa-mir-183 Kidney Neoplasms 26091793 High serum miR-183 level is associated with poor responsiveness of renal cancer to natural killer cells. -circulation_biomarker_prognosis_up hsa-mir-551b "Leukemia, Myeloid, Acute" 26108690 MicroRNA-551b is highly expressed in hematopoietic stem cells and a biomarker for relapse and poor prognosis in acute myeloid leukemia. -circulation_biomarker_prognosis_up hsa-mir-483 "Adenocarcinoma, Pancreatic Ductal" 26124009 Elevated miR-483-3p expression is an early event and indicates poor prognosis in pancreatic ductal adenocarcinoma. -circulation_biomarker_prognosis_up hsa-mir-122 "Carcinoma, Hepatocellular" 26129878 High plasma microRNA-122 expression was associated with poor OS in patients with HBV-related hepatocellular carcinoma who underwent RFA. -circulation_biomarker_prognosis_up hsa-mir-21 Prostate Neoplasms 26247873 "Our study demonstrates that high miR-21 expression levels in PBMCs were correlated with the presence, recurrence, and metastasis of PCa and that this may be a useful biomarker for screening PCa and monitoring the risk of Pca recurrence and metastasis." -circulation_biomarker_prognosis_up hsa-mir-141 Malignant Neoplasms [unspecific] 26556949 "Our findings indicated that, compared to their tissue counterparts, the expression level of miR-200c and miR-141 in peripheral blood may be more effective for monitoring cancer prognosis. High miR-141 expression was better at predicting tumor progression than survival for malignant tumors." -circulation_biomarker_prognosis_up hsa-mir-203 Colorectal Carcinoma 26701878 "Serum miR-203 levels were significantly upregulated in a stage-dependent manner, and high miR-203 expression was associated with poor survival in patients with CRC in both patient cohorts." -circulation_biomarker_prognosis_up hsa-mir-21 "Adenocarcinoma, Pancreatic Ductal" 26705427 Upregulation of these microRNAs was associated with a significantly shorter overall survival and recurrence-free survival -circulation_biomarker_prognosis_up hsa-mir-210 "Adenocarcinoma, Pancreatic Ductal" 26705427 Upregulation of these microRNAs was associated with a significantly shorter overall survival and recurrence-free survival -circulation_biomarker_prognosis_up hsa-mir-34a "Lymphoma, B-Cell" 26854484 High miR-34a expression improves response to doxorubicin in diffuse large B-cell lymphoma. -circulation_biomarker_prognosis_up hsa-mir-125b "Lymphoma, Large B-Cell" 26870228 high miR-125b indicated poor prognosis -circulation_biomarker_prognosis_up hsa-mir-21 "Adenocarcinoma, Pancreatic Ductal" 26969625 Our meta-analysis indicated that elevated miR-21 expression level can predict poor prognosis in patients with PDAC. -circulation_biomarker_prognosis_up hsa-mir-17 "Lymphoma, Burkitt" 27044389 miR-17-92 cluster components analysis in Burkitt lymphoma: overexpression of miR-17 is associated with poor prognosis. -circulation_biomarker_prognosis_up hsa-mir-20a "Lymphoma, Burkitt" 27044389 We found that upregulated expression of miR-17 and miR-20a correlates with lack of pro-apoptotic Bim expression. -circulation_biomarker_prognosis_up hsa-mir-125b Rectum Adenocarcinoma 27081702 High miR-125b expression in tissue and serum were associated with a poor treatment response in LARC patients -circulation_biomarker_prognosis_up hsa-mir-21 Cervical Neoplasms 27101583 Increased circulating miR-21 expression in serum is associated with lymph node metastasis in patients with cervical cancer. -circulation_biomarker_prognosis_up hsa-mir-29c Diabetic Nephropathy 27279796 "miR-21, miR-29a/b/c and miR-192 could reflect DN pathogenesis" -circulation_biomarker_prognosis_up hsa-mir-21 "Carcinoma, Urothelial" 27383043 miR-21 may be a prognostic marker for cancer progression. -circulation_biomarker_prognosis_up hsa-mir-1260b Colorectal Carcinoma 27399918 The high expression level of miR-1260b is an independent prognostic biomarker that indicates a worse prognosis for patients with CRC. -circulation_biomarker_prognosis_up hsa-mir-10b Pancreatic Adenocarcinoma 27456015 We conclude that elevated miRNA-10b levels in station 8 lymph nodes could be utilized to assess risk for early disease progression in patients with periampullary tumors. -circulation_biomarker_prognosis_up hsa-mir-522 "Carcinoma, Hepatocellular" 27466991 Upregulation of miR-522 is associated with poor outcome of hepatocellular carcinoma. -circulation_biomarker_prognosis_up hsa-mir-18b "Carcinoma, Colon" 27485175 "The expression of several novel miRNAs were found to be tumour specific, e.g. miR-888, miR-523, miR-18b, miR-302a, miR-423-5p, miR-582-3p (p < 0.05)." -circulation_biomarker_prognosis_up hsa-mir-302a "Carcinoma, Colon" 27485175 "The expression of several novel miRNAs were found to be tumour specific, e.g. miR-888, miR-523, miR-18b, miR-302a, miR-423-5p, miR-582-3p (p < 0.05)." -circulation_biomarker_prognosis_up hsa-mir-423 "Carcinoma, Colon" 27485175 "The expression of several novel miRNAs were found to be tumour specific, e.g. miR-888, miR-523, miR-18b, miR-302a, miR-423-5p, miR-582-3p (p < 0.05)." -circulation_biomarker_prognosis_up hsa-mir-523 "Carcinoma, Colon" 27485175 "The expression of several novel miRNAs were found to be tumour specific, e.g. miR-888, miR-523, miR-18b, miR-302a, miR-423-5p, miR-582-3p (p < 0.05)." -circulation_biomarker_prognosis_up hsa-mir-582 "Carcinoma, Colon" 27485175 "The expression of several novel miRNAs were found to be tumour specific, e.g. miR-888, miR-523, miR-18b, miR-302a, miR-423-5p, miR-582-3p (p < 0.05)." -circulation_biomarker_prognosis_up hsa-mir-888 "Carcinoma, Colon" 27485175 "The expression of several novel miRNAs were found to be tumour specific, e.g. miR-888, miR-523, miR-18b, miR-302a, miR-423-5p, miR-582-3p (p < 0.05)." -circulation_biomarker_prognosis_up hsa-mir-101 "Carcinoma, Hepatocellular" 27498785 "High miR-101 expression, vascular invasion, tumor size â‰? cm and late pathological stage were the risk factors of recurrence-free survival rate." -circulation_biomarker_prognosis_up hsa-mir-155 "Leukemia, Myeloid, Acute" 27511899 High miR-155 expression is an adverse prognostic factor in pediatric NK-AML patients. -circulation_biomarker_prognosis_up hsa-mir-133a Hypertension 27514547 The hypertensive ocean seamen had significantly higher expression levels of microRNA21 and MicroRNA133a than the healthy ocean seamen. -circulation_biomarker_prognosis_up hsa-mir-21 Hypertension 27514547 The hypertensive ocean seamen had significantly higher expression levels of microRNA21 and MicroRNA133a than the healthy ocean seamen. -circulation_biomarker_prognosis_up hsa-mir-21 Glioblastoma 27531352 Further subgroup analysis indicated that increased expression of miRNA-21 was also associated with OS in GBM patients. -circulation_biomarker_prognosis_up hsa-mir-21 Glioma 27531352 Our analysis revealed that the high expression of miRNA-21 is associated with the worse OS in gliomas. -circulation_biomarker_prognosis_up hsa-mir-155 "Leukemia, Myeloid, Acute" 27531760 The high expression of miR-155 is an poor prognostic factor for patients with AML. -circulation_biomarker_prognosis_up hsa-mir-181c Cholangiocarcinoma 27533020 Down-regulation of NDRG2 and overexpression of miR-181c or LIF are significantly associated with a poorer overall survival (OS) in CCA patients. -circulation_biomarker_prognosis_up hsa-mir-126 Diabetic Foot 27623390 Increasing the miR-126 expression in the peripheral blood of patients with diabetic foot ulcers treated with maggot debridement therapy. -circulation_biomarker_prognosis_up hsa-mir-21 B-cell Childhood Acute Lymphoblastic Leukemia 28253825 Upregulation of microRNA-21 is a poor prognostic marker in patients with childhood B cell acute lymphoblastic leukemia. -circulation_biomarker_prognosis_up hsa-mir-203 Breast Neoplasms 28351024 the upregulation of circulating miR-203 in blood was associated with poor prognosis in colorectal cancer and breast cancer -circulation_biomarker_prognosis_up hsa-mir-203 Colorectal Carcinoma 28351024 the upregulation of circulating miR-203 in blood was associated with poor prognosis in colorectal cancer and breast cancer -circulation_biomarker_prognosis_up hsa-mir-146b "Leukemia, Myeloid, Acute" 28473658 high expression of hsa-miR-146b was independent poor prognostic factor -circulation_biomarker_prognosis_up hsa-mir-181c "Leukemia, Myeloid, Acute" 28473658 high expression of hsa-miR-181c and hsa-miR-4786 appeared to be favorable factors -circulation_biomarker_prognosis_up hsa-mir-206 Rhabdomyosarcoma 28834127 "Serum microRNA-206 levels were elevated and remained high after three cycles of vincristine, dactinomycin, and cyclophosphamide (VAC)" -circulation_biomarker_prognosis_up hsa-mir-146b Breast Neoplasms 29189128 "up-regulation of miR181b, miR-34a, miR-16, miR-15a and miR-146b-5p, and down-regulation of miR-19a and miR-19b have been shown following the treatment of several breast cancer cell lines with curcumin" -circulation_biomarker_prognosis_up hsa-mir-15a Breast Neoplasms 29189128 "up-regulation of miR181b, miR-34a, miR-16, miR-15a and miR-146b-5p, and down-regulation of miR-19a and miR-19b have been shown following the treatment of several breast cancer cell lines with curcumin" -circulation_biomarker_prognosis_up hsa-mir-16 Breast Neoplasms 29189128 "up-regulation of miR181b, miR-34a, miR-16, miR-15a and miR-146b-5p, and down-regulation of miR-19a and miR-19b have been shown following the treatment of several breast cancer cell lines with curcumin" -circulation_biomarker_prognosis_up hsa-mir-181b Breast Neoplasms 29189128 "up-regulation of miR181b, miR-34a, miR-16, miR-15a and miR-146b-5p, and down-regulation of miR-19a and miR-19b have been shown following the treatment of several breast cancer cell lines with curcumin" -circulation_biomarker_prognosis_up hsa-mir-34a Breast Neoplasms 29189128 "up-regulation of miR181b, miR-34a, miR-16, miR-15a and miR-146b-5p, and down-regulation of miR-19a and miR-19b have been shown following the treatment of several breast cancer cell lines with curcumin" -circulation_biomarker_prognosis_up hsa-mir-155 Stevens-Johnson Syndrome 29644860 "MiR-155 up-regulation wasdetected in PBMCs from all hypersensitive patients 24 h after drug treatment, while miR-18a and miR-21 expression was up-regulated after 48 h" -circulation_biomarker_prognosis_up hsa-mir-133b Atrial Fibrillation 29676832 "The miRNAs had different expression profiles dependent on the AF condition, with higher expression in the acute new-onset AF than well-controlled AF" -circulation_biomarker_prognosis_up hsa-mir-328 Atrial Fibrillation 29676832 "The miRNAs had different expression profiles dependent on the AF condition, with higher expression in the acute new-onset AF than well-controlled AF" -circulation_biomarker_prognosis_up hsa-mir-499 Atrial Fibrillation 29676832 "The miRNAs had different expression profiles dependent on the AF condition, with higher expression in the acute new-onset AF than well-controlled AF" -circulation_biomarker_prognosis_up hsa-mir-103a "Diabetes Mellitus, Type 1" 29679626 "miR-103a-3p, miR-155-5p, miR-200a-3p, and miR-210-3p were confirmed as being upregulated in recently-diagnosed T1DM patients compared with controls or patients with ¡Ý5?years of diagnosis" -circulation_biomarker_prognosis_up hsa-mir-155 "Diabetes Mellitus, Type 1" 29679626 "miR-103a-3p, miR-155-5p, miR-200a-3p, and miR-210-3p were confirmed as being upregulated in recently-diagnosed T1DM patients compared with controls or patients with ¡Ý5?years of diagnosis" -circulation_biomarker_prognosis_up hsa-mir-200a "Diabetes Mellitus, Type 1" 29679626 "miR-103a-3p, miR-155-5p, miR-200a-3p, and miR-210-3p were confirmed as being upregulated in recently-diagnosed T1DM patients compared with controls or patients with ¡Ý5?years of diagnosis" -circulation_biomarker_prognosis_up hsa-mir-210 "Diabetes Mellitus, Type 1" 29679626 "miR-103a-3p, miR-155-5p, miR-200a-3p, and miR-210-3p were confirmed as being upregulated in recently-diagnosed T1DM patients compared with controls or patients with ¡Ý5?years of diagnosis" -circulation_biomarker_prognosis_up hsa-mir-502 Aneurysmal Subarachnoid Hemorrhage 29689401 Persistent High Levels of miR-502-5p Are Associated with Poor Neurologic Outcome in Patients with Aneurysmal Subarachnoid Hemorrhage. -circulation_biomarker_prognosis_up hsa-mir-20a "Carcinoma, Breast" 30099860 "baseline miR-222 overexpression, C2 miR-20a up-regulation and C2 miR-451 down-regulation were predictive markers of response to NCT in HR+/HER2- breast cancer" -circulation_biomarker_prognosis_up hsa-mir-222 "Carcinoma, Breast" 30099860 "baseline miR-222 overexpression, C2 miR-20a up-regulation and C2 miR-451 down-regulation were predictive markers of response to NCT in HR+/HER2- breast cancer" -circulation_biomarker_prognosis_up hsa-mir-126 Osteoarthritis 30105874 "Circulating miRNA expression profiles act as important roles in knee OA patients underwent celecoxib treatment, and miR-126-5p, miR-320a as well as miR-146a-5p might correlate with treatment response to celecoxib" -circulation_biomarker_prognosis_up hsa-mir-320a Osteoarthritis 30105874 "Circulating miRNA expression profiles act as important roles in knee OA patients underwent celecoxib treatment, and miR-126-5p, miR-320a as well as miR-146a-5p might correlate with treatment response to celecoxib" -circulation_biomarker_prognosis_up hsa-mir-509 "Leukemia, Myeloid, Acute" 30242879 "the high expression of hsa-miR-509 and hsa-miR-542 were independent poor prognostic factors, whereas that of hsa-miR-146a and hsa-miR-3667 had a trend to be favorable factors" -circulation_biomarker_prognosis_up hsa-mir-542 "Leukemia, Myeloid, Acute" 30242879 "the high expression of hsa-miR-509 and hsa-miR-542 were independent poor prognostic factors, whereas that of hsa-miR-146a and hsa-miR-3667 had a trend to be favorable factors" -circulation_biomarker_prognosis_up hsa-mir-1273g Ovarian Neoplasms 30264202 hsa-miR-1273g-3p may be used as a prognostic marker for recurrent EOC after chemotherapy -circulation_biomarker_prognosis_up hsa-mir-183 Major Depressive Disorder 30269040 Antidepressant treatment increased serum miR-183 and miR-212 levels in patients with major depressive disorder. -circulation_biomarker_prognosis_up hsa-mir-212 Major Depressive Disorder 30269040 Antidepressant treatment increased serum miR-183 and miR-212 levels in patients with major depressive disorder. -circulation_biomarker_prognosis_up hsa-mir-1246 Plasmodium Falciparum Malaria 30352683 "we identified five enriched upregulated miRNA sets (miR-3135b, miR-6780b-5p, miR-1246, miR-6126, and miR-3613-5p) as potential blood biomarkers of immunopathological status and prediction of early host responses, disease prognosis, and severe outcomes in AIFM" -circulation_biomarker_prognosis_up hsa-mir-3135b Plasmodium Falciparum Malaria 30352683 "we identified five enriched upregulated miRNA sets (miR-3135b, miR-6780b-5p, miR-1246, miR-6126, and miR-3613-5p) as potential blood biomarkers of immunopathological status and prediction of early host responses, disease prognosis, and severe outcomes in AIFM" -circulation_biomarker_prognosis_up hsa-mir-3613 Plasmodium Falciparum Malaria 30352683 "we identified five enriched upregulated miRNA sets (miR-3135b, miR-6780b-5p, miR-1246, miR-6126, and miR-3613-5p) as potential blood biomarkers of immunopathological status and prediction of early host responses, disease prognosis, and severe outcomes in AIFM" -circulation_biomarker_prognosis_up hsa-mir-6126 Plasmodium Falciparum Malaria 30352683 "we identified five enriched upregulated miRNA sets (miR-3135b, miR-6780b-5p, miR-1246, miR-6126, and miR-3613-5p) as potential blood biomarkers of immunopathological status and prediction of early host responses, disease prognosis, and severe outcomes in AIFM" -circulation_biomarker_prognosis_up hsa-mir-6780b Plasmodium Falciparum Malaria 30352683 "we identified five enriched upregulated miRNA sets (miR-3135b, miR-6780b-5p, miR-1246, miR-6126, and miR-3613-5p) as potential blood biomarkers of immunopathological status and prediction of early host responses, disease prognosis, and severe outcomes in AIFM" -circulation_biomarker_prognosis_up hsa-mir-200c Colorectal Carcinoma 30381824 Detection of Circulating MicroRNAs with Ago2 Complexes to Monitor the Tumor Dynamics of Colorectal Cancer Patients during Chemotherapy. -epigenetics hsa-mir-195 "Carcinoma, Hepatocellular" 17188425 "miRNA-195 expression is decreased in HCC compared to nontumor liver [59], and is also deleted in lung cancer [65], suggesting it is tumor related. miRNA-195 alters the expression of methyl-CpG binding protein 2 (which alters DNA methylation), the SKI oncogene, and a Bcl-2 like protein [59], suggesting miRNA-195 may act as a tumor suppressor in HCC." -epigenetics hsa-mir-127 Colon Neoplasms 17355635 "Human miR-127 is embedded in a CpG island and is silenced in several human cancers including bladder, prostate and colon cancer and has been suggested to play a role as a possible tumour suppressor gene." -epigenetics hsa-mir-127 Prostate Neoplasms 17355635 "Human miR-127 is embedded in a CpG island and is silenced in several human cancers including bladder, prostate and colon cancer and has been suggested to play a role as a possible tumour suppressor gene." -epigenetics hsa-mir-127 Urinary Bladder Cancer 17355635 "Human miR-127 is embedded in a CpG island and is silenced in several human cancers including bladder, prostate and colon cancer and has been suggested to play a role as a possible tumour suppressor gene." -epigenetics hsa-mir-29a Lung Neoplasms 17890317 "mir-29 family (29a,b,c) reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B." -epigenetics hsa-mir-29b Lung Neoplasms 17890317 MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. -epigenetics hsa-mir-29b-1 Lung Neoplasms 17890317 "mir-29 family (29a,b,c) reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B." -epigenetics hsa-mir-29c Lung Neoplasms 17890317 "mir-29 family (29a,b,c) reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B." -epigenetics hsa-mir-34b Colorectal Carcinoma 18519671 "Our results suggest that miR-34b/c and BTG4 are novel tumor suppressors in CRC and that the miR-34b/c CpG island, which bidirectionally regulates miR-34b/c and BTG4, is a frequent target of epigenetic silencing in CRC." -epigenetics hsa-mir-34c Colorectal Carcinoma 18519671 "Our results suggest that miR-34b/c and BTG4 are novel tumor suppressors in CRC and that the miR-34b/c CpG island, which bidirectionally regulates miR-34b/c and BTG4, is a frequent target of epigenetic silencing in CRC." -epigenetics hsa-mir-1 Cardiomegaly 18539123 "Microinjecting fragments of either the coding region or the related microRNA miR-1 led to high levels of expression of homologous RNA, resulting in an epigenetic defect, cardiac hypertrophy, whose efficient hereditary transmission correlated with the presence of miR-1 in the sperm nucleus." -epigenetics hsa-mir-34a Neoplasms [unspecific] 18719384 "miR-34a: inactivation, Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer" -epigenetics hsa-mir-34b Neoplasms [unspecific] 18768788 miR-34b: were found to undergo specific hypermethylation-associated silencing in cancer cells compared with normal tissues -epigenetics hsa-mir-34c Neoplasms [unspecific] 18768788 miR-34c: were found to undergo specific hypermethylation-associated silencing in cancer cells compared with normal tissues -epigenetics hsa-mir-9-1 Neoplasms [unspecific] 18768788 miR-9: were found to undergo specific hypermethylation-associated silencing in cancer cells compared with normal tissues -epigenetics hsa-mir-9-2 Neoplasms [unspecific] 18768788 miR-9: were found to undergo specific hypermethylation-associated silencing in cancer cells compared with normal tissues -epigenetics hsa-mir-9-3 Neoplasms [unspecific] 18768788 miR-9: were found to undergo specific hypermethylation-associated silencing in cancer cells compared with normal tissues -epigenetics hsa-mir-126 Neoplasms [unspecific] 19116145 miR-126: a tumor supressor: Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 -epigenetics hsa-mir-29b-1 "Leukemia, Myeloid, Acute" 19211935 miR-29b: induces global DNA hypomethylation and tumor suppressor gene re-expression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1 -epigenetics hsa-mir-29b-2 "Leukemia, Myeloid, Acute" 19211935 miR-29b: induces global DNA hypomethylation and tumor suppressor gene re-expression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1 -epigenetics hsa-mir-107 Pancreatic Neoplasms 19407485 Epigenetic silencing of MicroRNA miR-107 regulates cyclin-dependent kinase 6 expression in pancreatic cancer. -epigenetics hsa-mir-512 Gastric Neoplasms 19503096 Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells. -epigenetics hsa-mir-22 "Leukemia, Lymphoblastic, Acute" 19807731 "Thus, accumulation of H3K27triM independent of promoter DNA methylation may be a novel epigenetic mechanism for MIR22 silencing in ALL." -epigenetics hsa-mir-124-1 "Carcinoma, Hepatocellular" 19843643 miR-124:miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma. -epigenetics hsa-mir-124-2 "Carcinoma, Hepatocellular" 19843643 miR-124:miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma. -epigenetics hsa-mir-124-3 "Carcinoma, Hepatocellular" 19843643 miR-124:miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma. -epigenetics hsa-mir-203 "Carcinoma, Hepatocellular" 19843643 miR-203:miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma. -epigenetics hsa-mir-212 Gastric Neoplasms 20020497 miR-212:miR-212 is downregulated and suppresses methyl-CpG-binding protein MeCP2 in human gastric cancer -epigenetics hsa-mir-193b Prostate Neoplasms 20073067 miR-193b:miR-193b is an epigenetically regulated putative tumor suppressor in prostate cancer -epigenetics hsa-mir-181c Gastric Neoplasms 20080834 miR-181c:Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis. -epigenetics hsa-mir-137 "Squamous Cell Carcinoma, Oral" 20197299 miR-137:MicroRNA-137 promoter methylation in oral rinses from patients with squamous cell carcinoma of the head and neck is associated with gender and body mass index -epigenetics hsa-mir-148a Lung Neoplasms 20431052 miR-148a:The silencing of microRNA 148a production by DNA hypermethylation is an early event in pancreatic carcinogenesis -epigenetics hsa-mir-124-1 Myelodysplastic Syndromes 20448201 miRNA-124:Methylation and silencing of miRNA-124 by EVI1 and self-renewal exhaustion of hematopoietic stem cells in murine myelodysplastic syndrome -epigenetics hsa-mir-124-2 Myelodysplastic Syndromes 20448201 miRNA-124:Methylation and silencing of miRNA-124 by EVI1 and self-renewal exhaustion of hematopoietic stem cells in murine myelodysplastic syndrome -epigenetics hsa-mir-124-3 Myelodysplastic Syndromes 20448201 miRNA-124:Methylation and silencing of miRNA-124 by EVI1 and self-renewal exhaustion of hematopoietic stem cells in murine myelodysplastic syndrome -epigenetics hsa-mir-27a Pancreatic Neoplasms 20488920 "microRNA-27a:Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a" -epigenetics hsa-mir-206 Waldenstrom Macroglobulinemia 20519629 miR-206:Waldenstr?m macroglobulinemia (WM) cells present with increased expression of microRNA-206 (miRNA-206) and reduced expression of miRNA-9 -epigenetics hsa-mir-9-1 Waldenstrom Macroglobulinemia 20519629 miR-9:Waldenstr?m macroglobulinemia (WM) cells present with increased expression of microRNA-206 (miRNA-206) and reduced expression of miRNA-9 -epigenetics hsa-mir-9-2 Waldenstrom Macroglobulinemia 20519629 miR-9:Waldenstr?m macroglobulinemia (WM) cells present with increased expression of microRNA-206 (miRNA-206) and reduced expression of miRNA-9 -epigenetics hsa-mir-152 "Carcinoma, Hepatocellular" 20578129 microRNA-152:a tumor-suppressive role of miR-152 in the epigenetic aberration of HBV-related HCC -epigenetics hsa-mir-181b-1 Inflammation 20797623 miR-181b-1:STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer -epigenetics hsa-mir-181b-1 Neoplasms [unspecific] 20797623 miR-181b-1:STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer -epigenetics hsa-mir-21 Inflammation 20797623 miR-21:STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer -epigenetics hsa-mir-21 Neoplasms [unspecific] 20797623 miR-21:STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer -epigenetics hsa-mir-34b Gastric Neoplasms 20924086 "These results suggest that miR-34b and miR-34c are novel tumor suppressors frequently silenced by DNA methylation in GC, that methylation of miR-34b/c is involved in an epigenetic field defect and that the methylation might be a predictive marker of GC risk." -epigenetics hsa-mir-34c Gastrointestinal Neoplasms 20924086 "These results suggest that miR-34b and miR-34c are novel tumor suppressors frequently silenced by DNA methylation in GC, that methylation of miR-34b/c is involved in an epigenetic field defect and that the methylation might be a predictive marker of GC risk." -epigenetics hsa-mir-375 Breast Neoplasms 20978187 Epigenetically deregulated microRNA-375 is involved in a positive feedback loop with estrogen receptor alpha in breast cancer cells. -epigenetics hsa-mir-212 Gastrointestinal Neoplasms 21053104 "The conclusion could be deduced from the study that decreased expression of miR-212 may be due to hypermethylation of CPI in gastric cancer cells, and miR-212 might act on the progression of gastric cancer through the potential target gene Myc." -epigenetics hsa-mir-1224 Urinary Bladder Cancer 21138856 hypermethylation was more frequent and dense in CpG shores than islands -epigenetics hsa-mir-1227 Urinary Bladder Cancer 21138856 hypermethylation was more frequent and dense in CpG shores than islands -epigenetics hsa-mir-1229 Urinary Bladder Cancer 21138856 hypermethylation was more frequent and dense in CpG shores than islands -epigenetics hsa-mir-149 Urinary Bladder Cancer 21138856 hypermethylation was more frequent and dense in CpG shores than islands -epigenetics hsa-mir-210 Urinary Bladder Cancer 21138856 hypermethylation was more frequent and dense in CpG shores than islands -epigenetics hsa-mir-212 Urinary Bladder Cancer 21138856 hypermethylation was more frequent and dense in CpG shores than islands -epigenetics hsa-mir-328 Urinary Bladder Cancer 21138856 hypermethylation was more frequent and dense in CpG shores than islands -epigenetics hsa-mir-503 Urinary Bladder Cancer 21138856 hypermethylation was more frequent and dense in CpG shores than islands -epigenetics hsa-mir-9-1 Urinary Bladder Cancer 21138856 hypermethylation was more frequent and dense in CpG shores than islands -epigenetics hsa-mir-9-2 Urinary Bladder Cancer 21138856 hypermethylation was more frequent and dense in CpG shores than islands -epigenetics hsa-mir-9-3 Urinary Bladder Cancer 21138856 hypermethylation was more frequent and dense in CpG shores than islands -epigenetics hsa-mir-373 Cholangiocarcinoma 21165562 Methyl-CpG binding protein MBD2 is implicated in methylation-mediated suppression of miR-373 in hilar Cholangiocarcinoma. -epigenetics hsa-mir-126 Systemic Lupus Erythematosus 21165896 MicroRNA-126 regulates DNA methylation in CD4(+) T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1. -epigenetics hsa-mir-129-2 Gastric Neoplasms 21213213 "upstream CpG-rich regions of mir-34b and mir-129-2 are frequently methylated in gastric cancer tissues compared with adjacent normal tissues, and their methylation status correlated inversely with their expression patterns." -epigenetics hsa-mir-34b Gastric Neoplasms 21213213 "upstream CpG-rich regions of mir-34b and mir-129-2 are frequently methylated in gastric cancer tissues compared with adjacent normal tissues, and their methylation status correlated inversely with their expression patterns." -epigenetics hsa-mir-34a Breast Neoplasms 21225432 "Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas." -epigenetics hsa-mir-34a "Carcinoma, Renal Cell" 21225432 "Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas." -epigenetics hsa-mir-34a Colorectal Carcinoma 21225432 "Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas." -epigenetics hsa-mir-34a Ovarian Neoplasms 21225432 "Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas." -epigenetics hsa-mir-34a Pancreatic Neoplasms 21225432 "Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas." -epigenetics hsa-mir-34a Sarcoma [unspecific] 21225432 "Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas." -epigenetics hsa-mir-34a Urinary Bladder Cancer 21225432 "Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas." -epigenetics hsa-mir-34b Breast Neoplasms 21225432 "Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas." -epigenetics hsa-mir-34b "Carcinoma, Renal Cell" 21225432 "Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas." -epigenetics hsa-mir-34b Colorectal Carcinoma 21225432 "Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas." -epigenetics hsa-mir-34b Ovarian Neoplasms 21225432 "Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas." -epigenetics hsa-mir-34b Pancreatic Neoplasms 21225432 "Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas." -epigenetics hsa-mir-34b Sarcoma [unspecific] 21225432 "Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas." -epigenetics hsa-mir-34b Urinary Bladder Cancer 21225432 "Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas." -epigenetics hsa-mir-34c Breast Neoplasms 21225432 "Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas." -epigenetics hsa-mir-34c "Carcinoma, Renal Cell" 21225432 "Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas." -epigenetics hsa-mir-34c Colorectal Carcinoma 21225432 "Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas." -epigenetics hsa-mir-34c Ovarian Neoplasms 21225432 "Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas." -epigenetics hsa-mir-34c Pancreatic Neoplasms 21225432 "Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas." -epigenetics hsa-mir-34c Sarcoma [unspecific] 21225432 "Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas." -epigenetics hsa-mir-34c Urinary Bladder Cancer 21225432 "Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas." -epigenetics hsa-mir-196b Prostate Neoplasms 21255435 "We find miR-205, miR-21, and miR-196b to be epigenetically repressed, and miR-615 epigenetically activated in prostate cancer cells." -epigenetics hsa-mir-205 Prostate Neoplasms 21255435 "We find miR-205, miR-21, and miR-196b to be epigenetically repressed, and miR-615 epigenetically activated in prostate cancer cells." -epigenetics hsa-mir-21 Prostate Neoplasms 21255435 "We find miR-205, miR-21, and miR-196b to be epigenetically repressed, and miR-615 epigenetically activated in prostate cancer cells." -epigenetics hsa-mir-29b-1 Atherosclerosis 21266537 "OxLDL up-regulates microRNA-29b, leading to epigenetic modifications of MMP-2/MMP-9 genes: a novel mechanism for cardiovascular diseases." -epigenetics hsa-mir-29b-2 Atherosclerosis 21266537 "OxLDL up-regulates microRNA-29b, leading to epigenetic modifications of MMP-2/MMP-9 genes: a novel mechanism for cardiovascular diseases." -epigenetics hsa-mir-335 Breast Neoplasms 21289068 MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer. -epigenetics hsa-mir-200b Neoplasms [unspecific] 21292642 Depletion of miR-200 in arsenite-transformed cells involved induction of the EMT-inducing transcription factors ZEB1 (zinc-finger E-box-binding homeobox factor 1) and ZEB2 and increased methylation of miR-200 promoters. -epigenetics hsa-mir-199a-1 Breast Neoplasms 21317930 "Axl receptor expression can be regulated by miR-34a and miR-199a/b, which are suppressed by promoter methylation in solid cancer cells" -epigenetics hsa-mir-199a-1 "Carcinoma, Lung, Non-Small-Cell" 21317930 "Axl receptor expression can be regulated by miR-34a and miR-199a/b, which are suppressed by promoter methylation in solid cancer cells" -epigenetics hsa-mir-199a-1 Colorectal Carcinoma 21317930 "Axl receptor expression can be regulated by miR-34a and miR-199a/b, which are suppressed by promoter methylation in solid cancer cells" -epigenetics hsa-mir-199a-2 Breast Neoplasms 21317930 "Axl receptor expression can be regulated by miR-34a and miR-199a/b, which are suppressed by promoter methylation in solid cancer cells" -epigenetics hsa-mir-199a-2 "Carcinoma, Lung, Non-Small-Cell" 21317930 "Axl receptor expression can be regulated by miR-34a and miR-199a/b, which are suppressed by promoter methylation in solid cancer cells" -epigenetics hsa-mir-199a-2 Colorectal Carcinoma 21317930 "Axl receptor expression can be regulated by miR-34a and miR-199a/b, which are suppressed by promoter methylation in solid cancer cells" -epigenetics hsa-mir-199b Breast Neoplasms 21317930 "Axl receptor expression can be regulated by miR-34a and miR-199a/b, which are suppressed by promoter methylation in solid cancer cells" -epigenetics hsa-mir-199b "Carcinoma, Lung, Non-Small-Cell" 21317930 "Axl receptor expression can be regulated by miR-34a and miR-199a/b, which are suppressed by promoter methylation in solid cancer cells" -epigenetics hsa-mir-199b Colorectal Carcinoma 21317930 "Axl receptor expression can be regulated by miR-34a and miR-199a/b, which are suppressed by promoter methylation in solid cancer cells" -epigenetics hsa-mir-34a Breast Neoplasms 21317930 "Axl receptor expression can be regulated by miR-34a and miR-199a/b, which are suppressed by promoter methylation in solid cancer cells" -epigenetics hsa-mir-34a "Carcinoma, Lung, Non-Small-Cell" 21317930 "Axl receptor expression can be regulated by miR-34a and miR-199a/b, which are suppressed by promoter methylation in solid cancer cells" -epigenetics hsa-mir-34a Colorectal Carcinoma 21317930 "Axl receptor expression can be regulated by miR-34a and miR-199a/b, which are suppressed by promoter methylation in solid cancer cells" -epigenetics hsa-mir-203 "Leukemia, Myeloid, Acute" 21323860 The frequent hsa-miR-203 methylation in lymphoid malignancies suggested a pathogenetic role of hsa-miR-203 methylation. -epigenetics hsa-mir-1-1 Colorectal Carcinoma 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-1-1 Endometrial Neoplasms 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-1-1 Gastrointestinal Neoplasms 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-124-1 Colorectal Carcinoma 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-124-1 Endometrial Neoplasms 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-124-1 Gastrointestinal Neoplasms 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-124-2 Colorectal Carcinoma 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-124-2 Endometrial Neoplasms 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-124-2 Gastrointestinal Neoplasms 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-124-3 Colorectal Carcinoma 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-124-3 Endometrial Neoplasms 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-124-3 Gastrointestinal Neoplasms 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-148a Colorectal Carcinoma 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-148a Endometrial Neoplasms 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-148a Gastrointestinal Neoplasms 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-152 Colorectal Carcinoma 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-152 Endometrial Neoplasms 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-152 Gastrointestinal Neoplasms 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-18b Colorectal Carcinoma 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-18b Endometrial Neoplasms 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-18b Gastrointestinal Neoplasms 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-200a Colorectal Carcinoma 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-200a Endometrial Neoplasms 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-200a Gastrointestinal Neoplasms 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-208a Colorectal Carcinoma 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-208a Endometrial Neoplasms 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-208a Gastrointestinal Neoplasms 21327300 "Compared with the respective normal tissues, the predominant alteration in tumor tissues was increased methylation for the miRNAs 1-1, 124a-1, 124a-2, 124a-3, 148a, 152, and 18b; decreased methylation for 200a and 208a;" -epigenetics hsa-mir-145 Prostate Neoplasms 21349819 this is the first report documenting that downregulation of miR-145 is through DNA methylation and p53 mutation pathways in prostate cancer. -epigenetics hsa-mir-124-1 Gastric Neoplasms 21365509 "Significant associations were found between hypermethylation of hsa-miR-124a and tumor size, differentiation, lymphatic metastasis, and invasion depth(P<0.01)." -epigenetics hsa-mir-124-2 Gastric Neoplasms 21365509 "Significant associations were found between hypermethylation of hsa-miR-124a and tumor size, differentiation, lymphatic metastasis, and invasion depth(P<0.01)." -epigenetics hsa-mir-124-3 Gastric Neoplasms 21365509 "Significant associations were found between hypermethylation of hsa-miR-124a and tumor size, differentiation, lymphatic metastasis, and invasion depth(P<0.01)." -epigenetics hsa-mir-34b "Carcinoma, Lung, Non-Small-Cell" 21383543 DNA hypermethylation of microRNA-34b/c has prognostic value for stage ¢ñ non-small cell lung cancer. -epigenetics hsa-mir-34c "Carcinoma, Lung, Non-Small-Cell" 21383543 DNA hypermethylation of microRNA-34b/c has prognostic value for stage ¢ñ non-small cell lung cancer. -epigenetics hsa-mir-199a-1 Testicular Neoplasms 21383689 "PODXL is a downstream effector mediating the action of miR199a-5p. This report identifies DNA methylation, miR-199a dysregulation and PODXL as critical factors in tumor malignancy." -epigenetics hsa-mir-199a-2 Testicular Neoplasms 21383689 "PODXL is a downstream effector mediating the action of miR199a-5p. This report identifies DNA methylation, miR-199a dysregulation and PODXL as critical factors in tumor malignancy." -epigenetics hsa-mir-193a "Leukemia, Myeloid, Acute" 21399664 MicroRNA-193a represses c-kit expression and functions as a methylation-silenced tumor suppressor in acute myeloid leukemia. -epigenetics hsa-mir-137 "Squamous Cell Carcinoma, Head and Neck" 21425146 MicroRNA-137 promoter methylation is associated with poorer overall survival in patients with squamous cell carcinoma of the head and neck. -epigenetics hsa-mir-203 Lymphoma 21454413 Epigenetic silencing of microRNA-203 dysregulates ABL1 expression and drives Helicobacter-associated gastric lymphomagenesis. -epigenetics hsa-mir-203 Urinary Bladder Cancer 21461574 hypermethylation of miR-124a and miR-203 in the precursor lesions compared to the control samples -epigenetics hsa-mir-181a-2 "Carcinoma, Hepatocellular" 21464043 "HBx promotes stemness by activating {beta}-catenin and epigenetic up-regulation of miR-181, both of which target EpCAM." -epigenetics hsa-mir-181b-1 "Carcinoma, Hepatocellular" 21464043 "HBx promotes stemness by activating {beta}-catenin and epigenetic up-regulation of miR-181, both of which target EpCAM." -epigenetics hsa-mir-181b-2 "Carcinoma, Hepatocellular" 21464043 "HBx promotes stemness by activating {beta}-catenin and epigenetic up-regulation of miR-181, both of which target EpCAM." -epigenetics hsa-mir-181c "Carcinoma, Hepatocellular" 21464043 "HBx promotes stemness by activating {beta}-catenin and epigenetic up-regulation of miR-181, both of which target EpCAM." -epigenetics hsa-mir-181d "Carcinoma, Hepatocellular" 21464043 "HBx promotes stemness by activating {beta}-catenin and epigenetic up-regulation of miR-181, both of which target EpCAM." -epigenetics hsa-mir-375 Esophageal Neoplasms 21533613 Epigenetic Silencing of MicroRNA-375 Regulates PDK1 Expression in Esophageal Cancer -epigenetics hsa-mir-126 Systemic Lupus Erythematosus 21538319 MicroRNA-126 regulates DNA methylation in CD4+ T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1. -epigenetics hsa-mir-24-1 "Leukemia, Myeloid, Acute" 21544199 miR-124-1 is epigenetically inactivated in Haematological Malignancies. -epigenetics hsa-mir-24-1 Lymphoma 21544199 miR-124-1 is epigenetically inactivated in Haematological Malignancies. -epigenetics hsa-mir-24-1 Multiple Myeloma 21544199 miR-124-1 is epigenetically inactivated in Haematological Malignancies. -epigenetics hsa-mir-129-2 Esophageal Neoplasms 21547903 "The methylation ratio of miR-34a, miR-34b/c and miR-129-2 is 66.7%(36/54), 40.7%(22/54), and 96.3%(52/54) respectively in ESCC, which are significantly higher than that in corresponding non-tumor tissues(p<0.01)." -epigenetics hsa-mir-129-2 "Squamous Cell Carcinoma, Esophageal" 21547903 "The methylation ratio of miR-34a, miR-34b/c and miR-129-2 is 66.7%(36/54), 40.7%(22/54), and 96.3%(52/54) respectively in ESCC, which are significantly higher than that in corresponding non-tumor tissues(p<0.01)." -epigenetics hsa-mir-34a Esophageal Neoplasms 21547903 "The methylation ratio of miR-34a, miR-34b/c and miR-129-2 is 66.7%(36/54), 40.7%(22/54), and 96.3%(52/54) respectively in ESCC, which are significantly higher than that in corresponding non-tumor tissues(p<0.01)." -epigenetics hsa-mir-34a "Squamous Cell Carcinoma, Esophageal" 21547903 "The methylation ratio of miR-34a, miR-34b/c and miR-129-2 is 66.7%(36/54), 40.7%(22/54), and 96.3%(52/54) respectively in ESCC, which are significantly higher than that in corresponding non-tumor tissues(p<0.01)." -epigenetics hsa-mir-34b Esophageal Neoplasms 21547903 "The methylation ratio of miR-34a, miR-34b/c and miR-129-2 is 66.7%(36/54), 40.7%(22/54), and 96.3%(52/54) respectively in ESCC, which are significantly higher than that in corresponding non-tumor tissues(p<0.01)." -epigenetics hsa-mir-34b "Squamous Cell Carcinoma, Esophageal" 21547903 "The methylation ratio of miR-34a, miR-34b/c and miR-129-2 is 66.7%(36/54), 40.7%(22/54), and 96.3%(52/54) respectively in ESCC, which are significantly higher than that in corresponding non-tumor tissues(p<0.01)." -epigenetics hsa-mir-34c Esophageal Neoplasms 21547903 "The methylation ratio of miR-34a, miR-34b/c and miR-129-2 is 66.7%(36/54), 40.7%(22/54), and 96.3%(52/54) respectively in ESCC, which are significantly higher than that in corresponding non-tumor tissues(p<0.01)." -epigenetics hsa-mir-34c "Squamous Cell Carcinoma, Esophageal" 21547903 "The methylation ratio of miR-34a, miR-34b/c and miR-129-2 is 66.7%(36/54), 40.7%(22/54), and 96.3%(52/54) respectively in ESCC, which are significantly higher than that in corresponding non-tumor tissues(p<0.01)." -epigenetics hsa-mir-10b Gastric Neoplasms 21562367 "miR-10b methylation may be a useful molecular biomarker for assessing the risk of gastric cancer development, and modulation of miR-10b may represent a therapeutic approach for treating gastric cancer." -epigenetics hsa-mir-34b Colorectal Carcinoma 21610744 Epigenetically silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer. -epigenetics hsa-mir-34c Colorectal Carcinoma 21610744 Epigenetically silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer. -epigenetics hsa-mir-132 Pancreatic Neoplasms 21665894 Downregulation of miR-132 by promoter methylation contributes to pancreatic cancer development. -epigenetics hsa-mir-345 Colorectal Carcinoma 21665895 "MicroRNA 345, a methylation-sensitive microRNA is involved in cell proliferation and invasion in human colorectal cancer." -epigenetics hsa-mir-34b Mesothelioma 21673066 Epigenetic Silencing of MicroRNA-34b/c Plays an Important Role in the Pathogenesis of Malignant Pleural Mesothelioma. -epigenetics hsa-mir-34c Mesothelioma 21673066 Epigenetic Silencing of MicroRNA-34b/c Plays an Important Role in the Pathogenesis of Malignant Pleural Mesothelioma. -epigenetics hsa-mir-221 Breast Neoplasms 21673316 TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer. -epigenetics hsa-mir-196a-2 "Carcinoma, Hepatocellular" 21692953 The CC genotype of the miR-196a-2 rs11614913 polymorphism is associated with increased risk of HCC development in this Turkish population. -epigenetics hsa-mir-126 "Carcinoma, Lung, Non-Small-Cell" 21702040 mir-34b and mir-126 were silenced by DNA methylation. -epigenetics hsa-mir-34b "Carcinoma, Lung, Non-Small-Cell" 21702040 mir-34b and mir-126 were silenced by DNA methylation. -epigenetics hsa-mir-143 "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 21706045 Methylation-mediated repression of microRNA-143 enhances MLL-AF4 oncogene expression. -epigenetics hsa-mir-373 Liver Neoplasms 21706058 "Thus, histone deacetylation of CDH1 and downregulation of miR-373, together with the previously demonstrated hypermethylation of CDH1 by HBx, may be important for the understanding of HBV-related carcinogenesis." -epigenetics hsa-mir-203 Multiple Myeloma 21707582 MIR203 is epigeneticlly silenced in multiple myeloma. -epigenetics hsa-mir-373 Colorectal Carcinoma 21785829 Epigenetic silencing of microRNA-373 plays an important role in regulating cell proliferation in colon cancer. -epigenetics hsa-mir-200a "Carcinoma, Hepatocellular" 21837748 The histone deacetylase 4/Sp1/miR-200a regulatory network contributes to aberrant histone acetylation in hepatocellular carcinoma. -epigenetics hsa-mir-152 Endometrial Neoplasms 21868754 miR-152 is a tumor suppressor microRNA that is silenced by DNA hypermethylation in endometrial cancer. -epigenetics hsa-mir-17 "Leukemia, Myeloid, Acute" 21897363 We propose that upon macrophage differentiation PU.1 represses the miR-17-92 cluster promoter by an Egr-2/Jarid1b-mediated H3K4 demethylation mechanism whose deregulation may contribute to leukaemic states. -epigenetics hsa-mir-18 "Leukemia, Myeloid, Acute" 21897363 We propose that upon macrophage differentiation PU.1 represses the miR-17-92 cluster promoter by an Egr-2/Jarid1b-mediated H3K4 demethylation mechanism whose deregulation may contribute to leukaemic states. -epigenetics hsa-mir-19a "Leukemia, Myeloid, Acute" 21897363 We propose that upon macrophage differentiation PU.1 represses the miR-17-92 cluster promoter by an Egr-2/Jarid1b-mediated H3K4 demethylation mechanism whose deregulation may contribute to leukaemic states. -epigenetics hsa-mir-19b-1 "Leukemia, Myeloid, Acute" 21897363 We propose that upon macrophage differentiation PU.1 represses the miR-17-92 cluster promoter by an Egr-2/Jarid1b-mediated H3K4 demethylation mechanism whose deregulation may contribute to leukaemic states. -epigenetics hsa-mir-20a "Leukemia, Myeloid, Acute" 21897363 We propose that upon macrophage differentiation PU.1 represses the miR-17-92 cluster promoter by an Egr-2/Jarid1b-mediated H3K4 demethylation mechanism whose deregulation may contribute to leukaemic states. -epigenetics hsa-mir-92-1 "Leukemia, Myeloid, Acute" 21897363 We propose that upon macrophage differentiation PU.1 represses the miR-17-92 cluster promoter by an Egr-2/Jarid1b-mediated H3K4 demethylation mechanism whose deregulation may contribute to leukaemic states. -epigenetics hsa-mir-124-1 Gastric Neoplasms 21914401 The hypermethylation of miRNA-34b/c and miRNA-124a gene promoters may play a crucial role in the occurrence and development of gastric carcinoma. -epigenetics hsa-mir-34b Gastric Neoplasms 21914401 The hypermethylation of miRNA-34b/c and miRNA-124a gene promoters may play a crucial role in the occurrence and development of gastric carcinoma. -epigenetics hsa-mir-34c Gastric Neoplasms 21914401 The hypermethylation of miRNA-34b/c and miRNA-124a gene promoters may play a crucial role in the occurrence and development of gastric carcinoma. -epigenetics hsa-mir-124-2 "Carcinoma, Lung, Non-Small-Cell" 21917081 "The methylation of mir-9-3, -124-2, and -124-3 was individually associated with an advanced T factor independently of age, sex, and smoking habit." -epigenetics hsa-mir-124-3 "Carcinoma, Lung, Non-Small-Cell" 21917081 "The methylation of mir-9-3, -124-2, and -124-3 was individually associated with an advanced T factor independently of age, sex, and smoking habit." -epigenetics hsa-mir-9-3 "Carcinoma, Lung, Non-Small-Cell" 21917081 "The methylation of mir-9-3, -124-2, and -124-3 was individually associated with an advanced T factor independently of age, sex, and smoking habit." -epigenetics hsa-mir-139 Gastric Neoplasms 21925125 HER2 Interacts with CD44 to Upregulate CXCR4 via Epigenetic Silencing of microRNA-139 in Gastric Cancer Cells. -epigenetics hsa-mir-9-1 Gastric Neoplasms 21931274 "In this study, we demonstrate that three independent genetic loci encoding for miR-9 (miR-9-1, miR-9-2 and miR-9-3) are simultaneously modified by DNA methylation in gastric cancer cells. Methylation-mediated silencing of these three miR-9 genes can be reactivated in gastric cancer cells through 5-Aza-dC treatment." -epigenetics hsa-mir-9-2 Gastric Neoplasms 21931274 "In this study, we demonstrate that three independent genetic loci encoding for miR-9 (miR-9-1, miR-9-2 and miR-9-3) are simultaneously modified by DNA methylation in gastric cancer cells. Methylation-mediated silencing of these three miR-9 genes can be reactivated in gastric cancer cells through 5-Aza-dC treatment." -epigenetics hsa-mir-9-3 Gastric Neoplasms 21931274 "In this study, we demonstrate that three independent genetic loci encoding for miR-9 (miR-9-1, miR-9-2 and miR-9-3) are simultaneously modified by DNA methylation in gastric cancer cells. Methylation-mediated silencing of these three miR-9 genes can be reactivated in gastric cancer cells through 5-Aza-dC treatment." -epigenetics hsa-mir-129-1 Thyroid Neoplasms 21946411 "Two HDACi, Trichostatin A and vorinostat, induced miR-129-5p overexpression, histone acetylation and cell death. In addition, miR-129-5p alone was sufficient to induce cell death and knockdown experiments showed that expression of this miRNA was required for HDACi-induced cell death. Moreover, miR-129-5p was also able to improve the anti-proliferative effects of other cancer drugs such as etoposide or HAMLET (human alpha lactalbumin made letal for tumor cells). Taken together, the data show that miR-129-5p is involved in the antitumor activity of HDACi and highlight that miRNA-driven cell death may be an efficient approach to cancer treatment." -epigenetics hsa-mir-129-2 Thyroid Neoplasms 21946411 "Two HDACi, Trichostatin A and vorinostat, induced miR-129-5p overexpression, histone acetylation and cell death. In addition, miR-129-5p alone was sufficient to induce cell death and knockdown experiments showed that expression of this miRNA was required for HDACi-induced cell death. Moreover, miR-129-5p was also able to improve the anti-proliferative effects of other cancer drugs such as etoposide or HAMLET (human alpha lactalbumin made letal for tumor cells). Taken together, the data show that miR-129-5p is involved in the antitumor activity of HDACi and highlight that miRNA-driven cell death may be an efficient approach to cancer treatment." -epigenetics hsa-mir-129-2 Gastric Neoplasms 21960261 "The methylation-silenced expression of the miRNA could be reactivated in gastric cancer cells by treatment with demethylating drugs in a time-dependent manner.Analysis of the methylation status of these miRNAs showed that the upstream CpG-rich regions of mir-34b and mir-129-2 are frequently methylated in gastric cancer tissues compared to adjacent normal tissues, and their methylation status correlated inversely with their expression patterns. The expression of miR-34b and miR-129-3p was downregulated by DNA hypermethylation in primary gastric cancers, and the low expression was associated with poor clinicopathological features." -epigenetics hsa-mir-34b Gastric Neoplasms 21960261 "The methylation-silenced expression of the miRNA could be reactivated in gastric cancer cells by treatment with demethylating drugs in a time-dependent manner.Analysis of the methylation status of these miRNAs showed that the upstream CpG-rich regions of mir-34b and mir-129-2 are frequently methylated in gastric cancer tissues compared to adjacent normal tissues, and their methylation status correlated inversely with their expression patterns. The expression of miR-34b and miR-129-3p was downregulated by DNA hypermethylation in primary gastric cancers, and the low expression was associated with poor clinicopathological features." -epigenetics hsa-mir-185 Glioma 21962230 MiR-185 Targets the DNA Methyltransferases 1 and Regulates Global DNA Methylation in human glioma. -epigenetics hsa-let-7e Breast Neoplasms 21969366 Jumonji/Arid1 B (JARID1B) promotes breast tumor cell cycle progression through epigenetic repression of micro RNA let-7e. -epigenetics hsa-mir-191 "Carcinoma, Hepatocellular" 21969817 Hypomethylation of the hsa-miR-191 Locus Causes High Expression of hsa-miR-191 and Promotes the Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma. -epigenetics hsa-mir-34b "Carcinoma, Lung, Small-Cell" 22047961 Frequent methylation and oncogenic role of microRNA-34b/c in small-cell lung cancer. -epigenetics hsa-mir-34c "Carcinoma, Lung, Small-Cell" 22047961 Frequent methylation and oncogenic role of microRNA-34b/c in small-cell lung cancer. -epigenetics hsa-mir-29a Influenza 22072783 Epigenetic Changes Mediated by miR29 Activate Cyclooxygenase-2 and Interferon Production during Viral Infection. -epigenetics hsa-mir-34c Breast Neoplasms 22074923 MiR-34c down-regulation via DNA methylation promotes self-renewal and epithelial-mesenchymal transition in breast tumor-initiating cells. -epigenetics hsa-mir-34b Neoplasms [unspecific] 22082000 "miR-34b/c were homozygously methylated in HEL cells but heterozygously in MEG-01. In HEL cells, homozygous miR-34b/c methylation was associated with miR silencing, and 5-aza-2'-deoxycytidine treatment led to re-expression of both miR-34b and miR-34c, consistent with that both miRs are under the regulation of the same promoter CpG island. miR-34a was heterozygously methylated in MEG-01 and K-562. miR-203 was completely unmethylated in K-562 and SET-2 but no MSP amplification was found in both HEL and MEG-01, suggestive of miR deletion. In primary samples, four each had miR-34b/c and -203 methylation, in which two had concomitant methylation of miR-34b/c and -203. miR-34a was methylated in one patient and none had methylation of miR-124-1." -epigenetics hsa-mir-34c Neoplasms [unspecific] 22082000 "miR-34b/c were homozygously methylated in HEL cells but heterozygously in MEG-01. In HEL cells, homozygous miR-34b/c methylation was associated with miR silencing, and 5-aza-2'-deoxycytidine treatment led to re-expression of both miR-34b and miR-34c, consistent with that both miRs are under the regulation of the same promoter CpG island. miR-34a was heterozygously methylated in MEG-01 and K-562. miR-203 was completely unmethylated in K-562 and SET-2 but no MSP amplification was found in both HEL and MEG-01, suggestive of miR deletion. In primary samples, four each had miR-34b/c and -203 methylation, in which two had concomitant methylation of miR-34b/c and -203. miR-34a was methylated in one patient and none had methylation of miR-124-1." -epigenetics hsa-mir-369 "Leukemia, Myeloid, Chronic" 22089542 "The CpG islands in the upstream regions of miR-663, miR-369, miR-615, and miR-410, and promoter activity was detected in the upstream region of pre-miR-663. We found that a decrease in methylation of a CpG island could up-regulate the expression of miR-663, suggesting that miR-663 could be regulated by DNA methylation." -epigenetics hsa-mir-410 "Leukemia, Myeloid, Chronic" 22089542 "The CpG islands in the upstream regions of miR-663, miR-369, miR-615, and miR-410, and promoter activity was detected in the upstream region of pre-miR-663. We found that a decrease in methylation of a CpG island could up-regulate the expression of miR-663, suggesting that miR-663 could be regulated by DNA methylation." -epigenetics hsa-mir-615 "Leukemia, Myeloid, Chronic" 22089542 "The CpG islands in the upstream regions of miR-663, miR-369, miR-615, and miR-410, and promoter activity was detected in the upstream region of pre-miR-663. We found that a decrease in methylation of a CpG island could up-regulate the expression of miR-663, suggesting that miR-663 could be regulated by DNA methylation." -epigenetics hsa-mir-663a "Leukemia, Myeloid, Chronic" 22089542 "The CpG islands in the upstream regions of miR-663, miR-369, miR-615, and miR-410, and promoter activity was detected in the upstream region of pre-miR-663. We found that a decrease in methylation of a CpG island could up-regulate the expression of miR-663, suggesting that miR-663 could be regulated by DNA methylation." -epigenetics hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 22096249 "Histone deacetylases mediate the silencing of miR-15a, miR-16 and miR-29b in chronic lymphocytic leukemia." -epigenetics hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 22096249 "Histone deacetylases mediate the silencing of miR-15a, miR-16 and miR-29b in chronic lymphocytic leukemia." -epigenetics hsa-mir-16-2 "Leukemia, Lymphocytic, Chronic, B-Cell" 22096249 "Histone deacetylases mediate the silencing of miR-15a, miR-16 and miR-29b in chronic lymphocytic leukemia." -epigenetics hsa-mir-29b-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 22096249 "Histone deacetylases mediate the silencing of miR-15a, miR-16 and miR-29b in chronic lymphocytic leukemia." -epigenetics hsa-mir-29b-2 "Leukemia, Lymphocytic, Chronic, B-Cell" 22096249 "Histone deacetylases mediate the silencing of miR-15a, miR-16 and miR-29b in chronic lymphocytic leukemia." -epigenetics hsa-mir-212 "Carcinoma, Lung, Non-Small-Cell" 22110741 "We identified histone modifications rather than DNA hypermethylation as epigenetic events that regulate miR-212 levels in NSCLC. Moreover, we found that miR-212 silencing in vivo is closely associated with the severity of the disease." -epigenetics hsa-mir-193a "Carcinoma, Hepatocellular" 22117060 DNA methylation regulated miR-193a-3p dictates resistance of hepatocellular carcinoma to 5-fluorouracil via SRSF2. -epigenetics hsa-mir-127 "Carcinoma, Oral" 22132151 "MiR-375 is repressed and miR-127 activated in OSCC, and we confirm previous reports of miR-137 hypermethylation in oral cancer. The miR-200 s/miR-205 were epigenetically activated in tumors vs normal tissues, but repressed in the absence of DNA hypermethylation specifically in CD44(high) oral CSCs. Aberrant miR-375 and miR-200a expression and miR-200c-141 methylation could be detected in and distinguish OSCC patient oral rinse and saliva from healthy volunteers." -epigenetics hsa-mir-137 "Carcinoma, Oral" 22132151 "MiR-375 is repressed and miR-127 activated in OSCC, and we confirm previous reports of miR-137 hypermethylation in oral cancer. The miR-200 s/miR-205 were epigenetically activated in tumors vs normal tissues, but repressed in the absence of DNA hypermethylation specifically in CD44(high) oral CSCs. Aberrant miR-375 and miR-200a expression and miR-200c-141 methylation could be detected in and distinguish OSCC patient oral rinse and saliva from healthy volunteers." -epigenetics hsa-mir-141 "Carcinoma, Oral" 22132151 "MiR-375 is repressed and miR-127 activated in OSCC, and we confirm previous reports of miR-137 hypermethylation in oral cancer. The miR-200 s/miR-205 were epigenetically activated in tumors vs normal tissues, but repressed in the absence of DNA hypermethylation specifically in CD44(high) oral CSCs. Aberrant miR-375 and miR-200a expression and miR-200c-141 methylation could be detected in and distinguish OSCC patient oral rinse and saliva from healthy volunteers." -epigenetics hsa-mir-200a "Carcinoma, Oral" 22132151 "MiR-375 is repressed and miR-127 activated in OSCC, and we confirm previous reports of miR-137 hypermethylation in oral cancer. The miR-200 s/miR-205 were epigenetically activated in tumors vs normal tissues, but repressed in the absence of DNA hypermethylation specifically in CD44(high) oral CSCs. Aberrant miR-375 and miR-200a expression and miR-200c-141 methylation could be detected in and distinguish OSCC patient oral rinse and saliva from healthy volunteers." -epigenetics hsa-mir-200c "Carcinoma, Oral" 22132151 "MiR-375 is repressed and miR-127 activated in OSCC, and we confirm previous reports of miR-137 hypermethylation in oral cancer. The miR-200 s/miR-205 were epigenetically activated in tumors vs normal tissues, but repressed in the absence of DNA hypermethylation specifically in CD44(high) oral CSCs. Aberrant miR-375 and miR-200a expression and miR-200c-141 methylation could be detected in and distinguish OSCC patient oral rinse and saliva from healthy volunteers." -epigenetics hsa-mir-375 "Carcinoma, Oral" 22132151 "MiR-375 is repressed and miR-127 activated in OSCC, and we confirm previous reports of miR-137 hypermethylation in oral cancer. The miR-200 s/miR-205 were epigenetically activated in tumors vs normal tissues, but repressed in the absence of DNA hypermethylation specifically in CD44(high) oral CSCs. Aberrant miR-375 and miR-200a expression and miR-200c-141 methylation could be detected in and distinguish OSCC patient oral rinse and saliva from healthy volunteers." -epigenetics hsa-mir-9-1 "Squamous Cell Carcinoma, Oral" 22133638 Methylation of microRNA-9 is a specific and sensitive biomarker for oral and oropharyngeal squamous cell carcinomas. -epigenetics hsa-mir-9-3 "Squamous Cell Carcinoma, Oral" 22133638 Methylation of microRNA-9 is a specific and sensitive biomarker for oral and oropharyngeal squamous cell carcinomas. -epigenetics hsa-mir-148a Gastric Neoplasms 22167392 MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in gastric cancer. -epigenetics hsa-mir-29b Cardiovascular Diseases [unspecific] 22226905 This article is part of a Special Issue entitled OxLDL causes both epigenetic modification and signaling regulation on the microRNA-29b gene: Novel mechanisms for cardiovascular diseases. -epigenetics hsa-mir-200b Breast Neoplasms 22231446 Methylation of functional promoters of the Hsa-mir-200b is associated with metastasis or hormone receptor status in advanced breast cancer. -epigenetics hsa-mir-519d "Carcinoma, Hepatocellular" 22262409 "In hepatocellular carcinoma miR-519d is upregulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2." -epigenetics hsa-mir-125b-1 Breast Neoplasms 22277129 "We observed a significant reduction on the expression of miR-125b1 in cancer cells in comparison with controls, suggesting that DNA methylation at the CpG island might reduce miR-125b1 expression." -epigenetics hsa-mir-193a "Carcinoma, Lung, Non-Small-Cell" 22282464 Genome-Wide miRNA Expression Profiling Identifies miR-9-3 and miR-193a as Targets for DNA Methylation in Non-Small Cell Lung Cancers. -epigenetics hsa-mir-9-3 "Carcinoma, Lung, Non-Small-Cell" 22282464 Genome-Wide miRNA Expression Profiling Identifies miR-9-3 and miR-193a as Targets for DNA Methylation in Non-Small Cell Lung Cancers. -epigenetics hsa-mir-31 Breast Neoplasms 22289355 miR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancer. -epigenetics hsa-mir-152 Atherosclerosis 22295098 MicroRNA-152 mediates DNMT1-regulated DNA methylation in the estrogen receptor ¦Á gene. -epigenetics hsa-mir-17 Colorectal Carcinoma 22308110 Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR-17-92 cluster. -epigenetics hsa-mir-18a Colorectal Carcinoma 22308110 Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR-17-92 cluster. -epigenetics hsa-mir-19a Colorectal Carcinoma 22308110 Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR-17-92 cluster. -epigenetics hsa-mir-19b-1 Colorectal Carcinoma 22308110 Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR-17-92 cluster. -epigenetics hsa-mir-20a Colorectal Carcinoma 22308110 Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR-17-92 cluster. -epigenetics hsa-mir-92a-1 Colorectal Carcinoma 22308110 Histone deacetylase inhibition in colorectal cancer cells reveals competing roles for members of the oncogenic miR-17-92 cluster. -epigenetics hsa-mir-132 Prostate Neoplasms 22310291 DNA methylation silences miR-132 in prostate cancer. -epigenetics hsa-mir-34a Prostate Neoplasms 22347519 Epigenetic silencing of miR-34a in human prostate cancer cells and tumor tissue specimens can be reversed by BR-DIM treatment. -epigenetics hsa-let-7c "Carcinoma, Hepatocellular" 22370893 "Enhancer of zeste homolog 2 (EZH2) epigenetically silences multiple tumor suppressor miRNAs (miR-139-5p, miR-125b, miR-101, let-7c, and miR-200b) to promote liver cancer metastasis." -epigenetics hsa-mir-101-1 "Carcinoma, Hepatocellular" 22370893 "Enhancer of zeste homolog 2 (EZH2) epigenetically silences multiple tumor suppressor miRNAs (miR-139-5p, miR-125b, miR-101, let-7c, and miR-200b) to promote liver cancer metastasis." -epigenetics hsa-mir-125b-1 "Carcinoma, Hepatocellular" 22370893 "Enhancer of zeste homolog 2 (EZH2) epigenetically silences multiple tumor suppressor miRNAs (miR-139-5p, miR-125b, miR-101, let-7c, and miR-200b) to promote liver cancer metastasis." -epigenetics hsa-mir-125b-2 "Carcinoma, Hepatocellular" 22370893 "Enhancer of zeste homolog 2 (EZH2) epigenetically silences multiple tumor suppressor miRNAs (miR-139-5p, miR-125b, miR-101, let-7c, and miR-200b) to promote liver cancer metastasis." -epigenetics hsa-mir-139 "Carcinoma, Hepatocellular" 22370893 "Enhancer of zeste homolog 2 (EZH2) epigenetically silences multiple tumor suppressor miRNAs (miR-139-5p, miR-125b, miR-101, let-7c, and miR-200b) to promote liver cancer metastasis." -epigenetics hsa-mir-200b "Carcinoma, Hepatocellular" 22370893 "Enhancer of zeste homolog 2 (EZH2) epigenetically silences multiple tumor suppressor miRNAs (miR-139-5p, miR-125b, miR-101, let-7c, and miR-200b) to promote liver cancer metastasis." -epigenetics hsa-mir-675 Eosinophilic Esophagitis 22391115 EoE remission induced a single miRNA (miR-675) likely to be involved in DNA methylation. -epigenetics hsa-mir-203 Breast Neoplasms 22393463 Epigenetic Silencing of miR-203 Upregulates SNAI2 and Contributes to the Invasiveness of Malignant Breast Cancer Cells. -epigenetics hsa-mir-199b Medulloblastoma 22411914 "The micro-RNA 199b-5p regulatory circuit involves Hes1, CD15, and epigenetic modifications in medulloblastoma." -epigenetics hsa-mir-224 "Carcinoma, Hepatocellular" 22459148 MicroRNA-224 is up-regulated in hepatocellular carcinoma through epigenetic mechanisms. -epigenetics hsa-let-7b Liver Neoplasms 22683924 Downregulation of HMGA2 by the pan-deacetylase inhibitor panobinostat is dependent on hsa-let-7b expression in liver cancer cell lines. -epigenetics hsa-mir-137 Gastric Neoplasms 22703336 "Methylation frequency of 5 miR CpG islands (miR-9-1, miR-9-3, miR-137, miR-34b, and miR-210) gradually increased while the proportion of methylated miR-200b gradually decreased during gastric carcinogenesis" -epigenetics hsa-mir-210 Gastric Neoplasms 22703336 "Methylation frequency of 5 miR CpG islands (miR-9-1, miR-9-3, miR-137, miR-34b, and miR-210) gradually increased while the proportion of methylated miR-200b gradually decreased during gastric carcinogenesis" -epigenetics hsa-mir-34b Gastric Neoplasms 22703336 "Methylation frequency of 5 miR CpG islands (miR-9-1, miR-9-3, miR-137, miR-34b, and miR-210) gradually increased while the proportion of methylated miR-200b gradually decreased during gastric carcinogenesis" -epigenetics hsa-mir-9-1 Gastric Neoplasms 22703336 "Methylation frequency of 5 miR CpG islands (miR-9-1, miR-9-3, miR-137, miR-34b, and miR-210) gradually increased while the proportion of methylated miR-200b gradually decreased during gastric carcinogenesis" -epigenetics hsa-mir-9-3 Gastric Neoplasms 22703336 "Methylation frequency of 5 miR CpG islands (miR-9-1, miR-9-3, miR-137, miR-34b, and miR-210) gradually increased while the proportion of methylated miR-200b gradually decreased during gastric carcinogenesis" -epigenetics hsa-mir-218-1 Breast Neoplasms 22705304 miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer. -epigenetics hsa-mir-218-2 Breast Neoplasms 22705304 miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer. -epigenetics hsa-mir-7-1 Breast Neoplasms 22705304 miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer. -epigenetics hsa-mir-7-2 Breast Neoplasms 22705304 miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer. -epigenetics hsa-mir-7-3 Breast Neoplasms 22705304 miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer. -epigenetics hsa-mir-1-1 Colorectal Carcinoma 22766685 Silencing of miR-1-1 and miR-133a-2 cluster expression by DNA hypermethylation in colorectal cancer. -epigenetics hsa-mir-133a-1 Colorectal Carcinoma 22766685 Silencing of miR-1-1 and miR-133a-2 cluster expression by DNA hypermethylation in colorectal cancer. -epigenetics hsa-mir-133a-2 Colorectal Carcinoma 22766685 Silencing of miR-1-1 and miR-133a-2 cluster expression by DNA hypermethylation in colorectal cancer. -epigenetics hsa-mir-340 Neuroblastoma 22797059 miR-340 is upregulated by demethylation of an upstream genomic region that occurs during the process of neuroblastoma cell differentiation induced by all-trans retinoic acid (ATRA). -epigenetics hsa-mir-1256 Prostate Neoplasms 22805767 Epigenetic deregulation of miR-29a and miR-1256 by isoflavone contributes to the inhibition of prostate cancer cell growth and invasion. -epigenetics hsa-mir-29a Prostate Neoplasms 22805767 Epigenetic deregulation of miR-29a and miR-1256 by isoflavone contributes to the inhibition of prostate cancer cell growth and invasion. -epigenetics hsa-mir-124-1 Cholangiocarcinoma 22819820 Epigenetic regulation of miR-124 by Hepatitis C Virus core protein promotes migration and invasion of intrahepatic cholangiocarcinoma cells by targeting SMYD3. -epigenetics hsa-mir-124-2 Cholangiocarcinoma 22819820 Epigenetic regulation of miR-124 by Hepatitis C Virus core protein promotes migration and invasion of intrahepatic cholangiocarcinoma cells by targeting SMYD3. -epigenetics hsa-mir-149 Colorectal Carcinoma 22821729 SP1 mediates the link between methylation of the tumour suppressor miR-149 and outcome in colorectal cancer. -epigenetics hsa-mir-205 Prostate Neoplasms 22869146 Epigenetic-induced repression of microRNA-205 is associated with MED1 activation and a poorer prognosis in localized prostate cancer. -epigenetics hsa-mir-124a Colorectal Carcinoma 22870149 The results showed that the methylation of miR-124a and miR-34b/c occured early in colorectal carcinogenesis and certain CRCs may arise from a field defect defined by the epigenetic inactivation of miRs. -epigenetics hsa-mir-34b Colorectal Carcinoma 22870149 The results showed that the methylation of miR-124a and miR-34b/c occured early in colorectal carcinogenesis and certain CRCs may arise from a field defect defined by the epigenetic inactivation of miRs. -epigenetics hsa-mir-34c Colorectal Carcinoma 22870149 The results showed that the methylation of miR-124a and miR-34b/c occured early in colorectal carcinogenesis and certain CRCs may arise from a field defect defined by the epigenetic inactivation of miRs. -epigenetics hsa-mir-141 Esophageal Neoplasms 22921431 Inhibition of SOX17 by MicroRNA-141 and Methylation Activates the WNT Signaling Pathway in Esophageal Cancer. -epigenetics hsa-mir-31 Melanoma 22948084 Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma. -epigenetics hsa-mir-127 Osteosarcoma 22957032 "Treatment with 4-phenylbutyrate increased acetylation of histones associated with 14q32 miRNAs, but interestingly, robust restoration of 14q32 miRNA expression, attenuation of cMYC expression, and induction of apoptosis required concomitant treatment with 5-Azacytidine, an inhibitor of DNA methylation. combination of these chromatin-modifying drugs may be a useful adjuvant in the treatment of rapidly progressive osteosarcoma." -epigenetics hsa-mir-411 Osteosarcoma 22957032 "Treatment with 4-phenylbutyrate increased acetylation of histones associated with 14q32 miRNAs, but interestingly, robust restoration of 14q32 miRNA expression, attenuation of cMYC expression, and induction of apoptosis required concomitant treatment with 5-Azacytidine, an inhibitor of DNA methylation. combination of these chromatin-modifying drugs may be a useful adjuvant in the treatment of rapidly progressive osteosarcoma." -epigenetics hsa-mir-431 Osteosarcoma 22957032 "Treatment with 4-phenylbutyrate increased acetylation of histones associated with 14q32 miRNAs, but interestingly, robust restoration of 14q32 miRNA expression, attenuation of cMYC expression, and induction of apoptosis required concomitant treatment with 5-Azacytidine, an inhibitor of DNA methylation. combination of these chromatin-modifying drugs may be a useful adjuvant in the treatment of rapidly progressive osteosarcoma." -epigenetics hsa-mir-432 Osteosarcoma 22957032 "Treatment with 4-phenylbutyrate increased acetylation of histones associated with 14q32 miRNAs, but interestingly, robust restoration of 14q32 miRNA expression, attenuation of cMYC expression, and induction of apoptosis required concomitant treatment with 5-Azacytidine, an inhibitor of DNA methylation. combination of these chromatin-modifying drugs may be a useful adjuvant in the treatment of rapidly progressive osteosarcoma." -epigenetics hsa-mir-23b Prostate Neoplasms 23074286 miR-23b Represses Proto-oncogene Src Kinase and Functions as Methylation-Silenced Tumor Suppressor with Diagnostic and Prognostic Significance in Prostate Cancer -epigenetics hsa-mir-29b-1 Multiple Myeloma 23100393 DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma -epigenetics hsa-mir-29b-2 Multiple Myeloma 23100393 DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma -epigenetics hsa-mir-200a Breast Neoplasms 23112837 the expression and methylation status of miR-200f could be used as hypothetical biomarkers to assess the occurrence of EMT in breast cancer -epigenetics hsa-mir-200b Breast Neoplasms 23112837 the expression and methylation status of miR-200f could be used as hypothetical biomarkers to assess the occurrence of EMT in breast cancer -epigenetics hsa-mir-200c Breast Neoplasms 23112837 the expression and methylation status of miR-200f could be used as hypothetical biomarkers to assess the occurrence of EMT in breast cancer -epigenetics hsa-mir-149 Colorectal Carcinoma 23115050 Non-CpG island promoter hypomethylation and miR-149 regulate the expression of SRPX2 in colorectal cancer -epigenetics hsa-mir-137 "Squamous Cell Carcinoma, Oral" 23121285 MicroRNA-137 promoter methylation in oral lichen planus and oral squamous cell carcinoma -epigenetics hsa-mir-101-1 Hepatitis B Virus Infection 23124077 miR-101 is down-regulated by the hepatitis B virus x protein and induces aberrant DNA methylation by targeting DNA methyltransferase 3A -epigenetics hsa-mir-101-2 Hepatitis B Virus Infection 23124077 miR-101 is down-regulated by the hepatitis B virus x protein and induces aberrant DNA methylation by targeting DNA methyltransferase 3A -epigenetics hsa-mir-29b-1 Systemic Lupus Erythematosus 23142053 MicroRNA-29b contributes to DNA hypomethylation of CD4+ T cells in systemic lupus erythematosus by indirectly targeting DNA methyltransferase 1 -epigenetics hsa-mir-29b-2 Systemic Lupus Erythematosus 23142053 MicroRNA-29b contributes to DNA hypomethylation of CD4+ T cells in systemic lupus erythematosus by indirectly targeting DNA methyltransferase 1 -epigenetics hsa-mir-34b Prostate Neoplasms 23147995 "miRNA-34b Inhibits Prostate Cancer through Demethylation, Active Chromatin Modifications, and AKT Pathways" -epigenetics hsa-mir-29b-1 "Leukemia, Myeloid, Acute" 23178755 Increased anti-leukemic activity of decitabine via AR-42-induced upregulation of miR-29b: a novel epigenetic-targeting approach in acute myeloid leukemia -epigenetics hsa-mir-29b-2 "Leukemia, Myeloid, Acute" 23178755 Increased anti-leukemic activity of decitabine via AR-42-induced upregulation of miR-29b: a novel epigenetic-targeting approach in acute myeloid leukemia -epigenetics hsa-mir-29b-1 Ovarian Neoplasms 23179556 Anticancer role of MUC1 aptamer-miR-29b chimera in epithelial ovarian carcinoma cells through regulation of PTEN methylation -epigenetics hsa-mir-29b-2 Ovarian Neoplasms 23179556 Anticancer role of MUC1 aptamer-miR-29b chimera in epithelial ovarian carcinoma cells through regulation of PTEN methylation -epigenetics hsa-mir-211 Glioma 23183822 "Epigenetic Regulation of miRNA-211 by MMP-9 Governs Glioma Cell Apoptosis,Chemosensitivity and Radiosensitivity" -epigenetics hsa-mir-124 Bladder Neoplasms 23200812 "Among them, miR-137,miR-124-2, miR-124-3, and miR-9-3 were frequently and tumor-specifically methylated in primary cancers" -epigenetics hsa-mir-137 Bladder Neoplasms 23200812 "Among them, miR-137,miR-124-2, miR-124-3, and miR-9-3 were frequently and tumor-specifically methylated in primary cancers" -epigenetics hsa-mir-9 Bladder Neoplasms 23200812 "Among them, miR-137,miR-124-2, miR-124-3, and miR-9-3 were frequently and tumor-specifically methylated in primary cancers" -epigenetics hsa-mir-200a "Carcinoma, Hepatocellular" 23222811 Epigenetic activation of the MiR-200 family contributes to H19-mediated metastasis suppression in hepatocellular carcinoma -epigenetics hsa-mir-200b "Carcinoma, Hepatocellular" 23222811 Epigenetic activation of the MiR-200 family contributes to H19-mediated metastasis suppression in hepatocellular carcinoma -epigenetics hsa-mir-200c "Carcinoma, Hepatocellular" 23222811 Epigenetic activation of the MiR-200 family contributes to H19-mediated metastasis suppression in hepatocellular carcinoma -epigenetics hsa-mir-193a "Leukemia, Myeloid, Acute" 23223432 Epigenetic silencing of microRNA-193a contributes to leukemogenesis in t(8;21)acute myeloid leukemia by activating the PTEN/PI3K signal pathway -epigenetics hsa-mir-335 "Carcinoma, Hepatocellular" 23229728 Epigenetic silencing of miR-335 and its host gene MEST in hepatocellular carcinoma -epigenetics hsa-mir-31 Prostate Neoplasms 23233736 Epigenetic repression of miR-31 disrupts androgen receptor homeostasis and contributes to prostate cancer progression -epigenetics hsa-mir-34a Colon Neoplasms 23243217 Detection of miR-34a Promoter Methylation in Combination with Elevated Expression of c-Met and beta-Catenin Predicts Distant Metastasis of Colon Cancer -epigenetics hsa-mir-34a Breast Neoplasms 23292869 Downregulation of miR-34a in breast tumors is not associated with either p53 mutations or promoter hypermethylation while it correlates with metastasis -epigenetics hsa-mir-124-1 "Carcinoma, Renal Cell" 23321515 Hsa-mir-124-3 CpG island methylation is associated with advanced tumours and disease recurrence of patients with clear cell renal cell carcinoma -epigenetics hsa-mir-124-2 "Carcinoma, Renal Cell" 23321515 Hsa-mir-124-3 CpG island methylation is associated with advanced tumours and disease recurrence of patients with clear cell renal cell carcinoma -epigenetics hsa-mir-124-3 "Carcinoma, Renal Cell" 23321515 Hsa-mir-124-3 CpG island methylation is associated with advanced tumours and disease recurrence of patients with clear cell renal cell carcinoma -epigenetics hsa-mir-195 Gastric Neoplasms 23333942 MicroRNA-195 and microRNA-378 mediate tumor growth suppression by epigenetical regulation in gastric cancer -epigenetics hsa-mir-378a Gastric Neoplasms 23333942 MicroRNA-195 and microRNA-378 mediate tumor growth suppression by epigenetical regulation in gastric cancer -epigenetics hsa-mir-124-1 Pancreatic Neoplasms 23334332 Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1 -epigenetics hsa-mir-124-2 Pancreatic Neoplasms 23334332 Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1 -epigenetics hsa-mir-124-3 Pancreatic Neoplasms 23334332 Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1 -epigenetics hsa-mir-129-2 "Carcinoma, Hepatocellular" 23402613 Methylation-mediated repression of microRNA 129-2 enhances oncogenic SOX4 expression in HCC -epigenetics hsa-mir-200 Breast Neoplasms 23525011 Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem cell-like state -epigenetics hsa-mir-146a "Lymphoma, Burkitt" 23528241 "We concluded that similarly to the promoters of protein coding genes, both DNA methylation and histone modifications contribute to the host cell dependent expression of miR-146a." -epigenetics hsa-mir-129-1 "Carcinoma, Hepatocellular" 23580407 Frequent DNA methylation of MiR-129-2 and its potential clinical implication in hepatocellular carcinoma -epigenetics hsa-mir-129-2 "Carcinoma, Hepatocellular" 23580407 Frequent DNA methylation of MiR-129-2 and its potential clinical implication in hepatocellular carcinoma -epigenetics hsa-mir-1286 Human Papilloma Virus Infection 23732000 "We found hypermethylation of miR-432, miR-1286, miR-641, miR-1290, miR-1287 and miR-95 may have some relationship with HPV infection in cervical cell lines." -epigenetics hsa-mir-1287 Human Papilloma Virus Infection 23732000 "We found hypermethylation of miR-432, miR-1286, miR-641, miR-1290, miR-1287 and miR-95 may have some relationship with HPV infection in cervical cell lines." -epigenetics hsa-mir-1290 Human Papilloma Virus Infection 23732000 "We found hypermethylation of miR-432, miR-1286, miR-641, miR-1290, miR-1287 and miR-95 may have some relationship with HPV infection in cervical cell lines." -epigenetics hsa-mir-432 Human Papilloma Virus Infection 23732000 "We found hypermethylation of miR-432, miR-1286, miR-641, miR-1290, miR-1287 and miR-95 may have some relationship with HPV infection in cervical cell lines." -epigenetics hsa-mir-641 Human Papilloma Virus Infection 23732000 "We found hypermethylation of miR-432, miR-1286, miR-641, miR-1290, miR-1287 and miR-95 may have some relationship with HPV infection in cervical cell lines." -epigenetics hsa-mir-95 Human Papilloma Virus Infection 23732000 "We found hypermethylation of miR-432, miR-1286, miR-641, miR-1290, miR-1287 and miR-95 may have some relationship with HPV infection in cervical cell lines." -epigenetics hsa-mir-124a-2 "Carcinoma, Renal Cell" 23755536 "The frequency of methylation of six genes (miR-124a-2, -124a-3, -9-1, -9-3, -34b/c and -129-2) was significantly higher in tumor samples than in samples of histologically normal tissue" -epigenetics hsa-mir-124a-3 "Carcinoma, Renal Cell" 23755536 "The frequency of methylation of six genes (miR-124a-2, -124a-3, -9-1, -9-3, -34b/c and -129-2) was significantly higher in tumor samples than in samples of histologically normal tissue" -epigenetics hsa-mir-129-2 "Carcinoma, Renal Cell" 23755536 "The frequency of methylation of six genes (miR-124a-2, -124a-3, -9-1, -9-3, -34b/c and -129-2) was significantly higher in tumor samples than in samples of histologically normal tissue" -epigenetics hsa-mir-34b "Carcinoma, Renal Cell" 23755536 "The frequency of methylation of six genes (miR-124a-2, -124a-3, -9-1, -9-3, -34b/c and -129-2) was significantly higher in tumor samples than in samples of histologically normal tissue" -epigenetics hsa-mir-34c "Carcinoma, Renal Cell" 23755536 "The frequency of methylation of six genes (miR-124a-2, -124a-3, -9-1, -9-3, -34b/c and -129-2) was significantly higher in tumor samples than in samples of histologically normal tissue" -epigenetics hsa-mir-9-1 "Carcinoma, Renal Cell" 23755536 "The frequency of methylation of six genes (miR-124a-2, -124a-3, -9-1, -9-3, -34b/c and -129-2) was significantly higher in tumor samples than in samples of histologically normal tissue" -epigenetics hsa-mir-9-3 "Carcinoma, Renal Cell" 23755536 "The frequency of methylation of six genes (miR-124a-2, -124a-3, -9-1, -9-3, -34b/c and -129-2) was significantly higher in tumor samples than in samples of histologically normal tissue" -epigenetics hsa-mir-29a "Carcinoma, Hepatocellular" 23789939 miR-29a could regulate TGF-¦Â-induced EMT by affecting DNA methylation via the suppression of DNMT. -epigenetics hsa-mir-219 Breast Neoplasms 23813567 Aberrant DNA methylation of miR-219 promoter in long-term night shiftworkers. -epigenetics hsa-mir-10a Bladder Neoplasms 23867826 "Analyses in human urothelial cells identify methylation of miR-152, miR-200b and miR-10a genes as candidate bladder cancer biomarkers." -epigenetics hsa-mir-152 Bladder Neoplasms 23867826 "Analyses in human urothelial cells identify methylation of miR-152, miR-200b and miR-10a genes as candidate bladder cancer biomarkers." -epigenetics hsa-mir-200b Bladder Neoplasms 23867826 "Analyses in human urothelial cells identify methylation of miR-152, miR-200b and miR-10a genes as candidate bladder cancer biomarkers." -epigenetics hsa-mir-15a "Carcinoma, Lung, Non-Small-Cell" 23867991 Histone deacetylases inhibitor trichostatin A increases the expression of Dleu2/miR-15a/16-1 via HDAC3 in non-small cell lung cancer. -epigenetics hsa-mir-16-1 "Carcinoma, Lung, Non-Small-Cell" 23867991 Histone deacetylases inhibitor trichostatin A increases the expression of Dleu2/miR-15a/16-1 via HDAC3 in non-small cell lung cancer. -epigenetics hsa-mir-663 "Leukemia, Myeloid, Acute" 23870168 "Expression of miR-663 was significantly lower in pediatric AML cells compared to NBM controls; furthermore, a high frequency of miR-663 promoter hypermethylation was observed in both AML cell lines and pediatric AML samples.Inactivation of miR-663 by promoter hypermethylation could be affected by 5-Aza demethylation. These findings suggest that hypermethylation of the miR-663 promoter may be an early event in the development of pediatric AML." -epigenetics hsa-mir-126 Colorectal Carcinoma 23900443 Epigenetic silencing of miR-126 contributes to tumor invasion and angiogenesis in colorectal cancer. -epigenetics hsa-mir-29 "Carcinoma, Lung, Non-Small-Cell" 23939044 Suppression of Wnt signaling by the miR-29 family is mediated by demethylation of WIF-1 in non-small-cell lung cancer. -epigenetics hsa-mir-34b Gastric Neoplasms 23942619 Our results suggest that methylation of miR-34b/c in the mucosa of the noncancerous gastric body may be a useful biomarker for predicting the risk of metachronous GC. -epigenetics hsa-mir-34c Gastric Neoplasms 23942619 Our results suggest that methylation of miR-34b/c in the mucosa of the noncancerous gastric body may be a useful biomarker for predicting the risk of metachronous GC. -epigenetics hsa-mir-199a Testicular Neoplasms 23959088 "microRNA-199a-3p, DNMT3A, and aberrant DNA methylation in testicular cancer." -epigenetics hsa-mir-126 Systemic Lupus Erythematosus 23981988 The upregulation of miR-126 and its host gene EGFL7 expression in CD4+ T cells from SLE is associated with the hypomethylation of the EGFL7 promoter. -epigenetics hsa-mir-328 Breast Neoplasms 23991164 Methylation patterns in the miR-328 5'-flanking region are involved in the inter-individual difference in BCRP levels in human placenta -epigenetics hsa-mir-122 "Carcinoma, Hepatocellular" 24085423 The expression of miRNA-122 is regulated by DNA methylation and correlated with apoptosis of liver cancer cells. Methylation regulation of miRNA-122 expression might be involved in the development of hepatocellular carcinoma. -epigenetics hsa-mir-29 Neoplasms [unspecific] 24096364 The miR-29 family recurrently regulates active DNA demethylation pathway members TET1 and TDG. -epigenetics hsa-mir-203 "Leukemia, Myeloid, Acute, Pediatric" 24103876 miR-203 may not be regulated with methylation mechanism in pediatric acute leukemia. miR- 203 may be a protooncogene involved in the formation of pediatric acute leukemia and ALL. Further analyses indicated that high expression of miR-203 may be associated with poor prognosis of pediatric ALL and acute leukemia. -epigenetics hsa-mir-125b Melanoma 24118912 "the reduction in miR-125b expression in pigmented cells was at least partially due to the hypermethylation of the MIR125B-1 promoter, and miR-125b expression was regulated by intracellular cAMP levels." -epigenetics hsa-mir-200 Hepatoblastoma 24122292 The strong correlation between expression and DNA methylation suggests a major role for this epigenetic mark in the regulation of the miR-141-200c locus. -epigenetics hsa-mir-205 Hepatoblastoma 24122292 The strong correlation between expression and DNA methylation suggests a major role for this epigenetic mark in the regulation of the miR-141-200c locus. -epigenetics hsa-mir-214 Lung Fibrosis 24122720 "Stable decreases in miR-124 expression contribute to an epigenetically reprogrammed, highly proliferative, migratory, and inflammatory phenotype of hypertensive pulmonary adventitial fibroblasts. Thus, therapies directed at restoring miR-124 function, including histone deacetylase inhibitors,should be investigated." -epigenetics hsa-mir-34b Early-Stage Lung Adenocarcinoma 24130071 Epigenetic inactivation of microRNA-34b/c predicts poor disease-free survival in early-stage lung adenocarcinoma. -epigenetics hsa-mir-34c Early-Stage Lung Adenocarcinoma 24130071 Epigenetic inactivation of microRNA-34b/c predicts poor disease-free survival in early-stage lung adenocarcinoma. -epigenetics hsa-mir-29b Liver Fibrosis 24138392 Curcumin up-regulates phosphatase and tensin homologue deleted on chromosome 10 through microRNA-mediated control of DNA methylation--a novel mechanism suppressing liver fibrosis. -epigenetics hsa-mir-34b Pleural Mesothelioma 24168922 "Our digital MSP assay can quantify miR-34b/c methylation in serum-circulating DNA. The degree of miR-34b/c methylation in serum-circulating DNA is associated with MPM, suggesting that this approach might be useful for the establishment of a new detection system for MPM." -epigenetics hsa-mir-34c Pleural Mesothelioma 24168922 "Our digital MSP assay can quantify miR-34b/c methylation in serum-circulating DNA. The degree of miR-34b/c methylation in serum-circulating DNA is associated with MPM, suggesting that this approach might be useful for the establishment of a new detection system for MPM." -epigenetics hsa-mir-375 Prostate Neoplasms 24173286 Androgen receptor is negatively correlated with the methylation-mediated transcriptional repression of miR-375 in human prostate cancer cells. -epigenetics hsa-mir-143 Breast Neoplasms 24218337 MicroRNA-143 is downregulated in breast cancer and regulates DNA methyltransferases 3A in breast cancer cells. -epigenetics hsa-mir-124a Rheumatoid Arthritis 24223605 "The methylation status of miR-124a seen in this study concurs with that reported in tumor cells, indicating epigenetic dysregulation constituents, a mechanism in the development of rheumatoid arthritis." -epigenetics hsa-mir-203 Rhabdomyosarcoma 24247238 "miR-203, a tumor suppressor frequently down-regulated by promoter hypermethylation in rhabdomyosarcoma." -epigenetics hsa-mir-148b Breast Neoplasms 24257477 "Our data provide novel evidence of the mechanisms behind miRNA dysregulation in breast cancer. The study contributes to the understanding of how methylation and copy number alterations influence miRNA expression, emphasizing miRNA functionality through redundant encoding, and suggests novel miRNAs important in breast cancer." -epigenetics hsa-mir-151a Breast Neoplasms 24257477 "Our data provide novel evidence of the mechanisms behind miRNA dysregulation in breast cancer. The study contributes to the understanding of how methylation and copy number alterations influence miRNA expression, emphasizing miRNA functionality through redundant encoding, and suggests novel miRNAs important in breast cancer." -epigenetics hsa-mir-21 Breast Neoplasms 24257477 "Our data provide novel evidence of the mechanisms behind miRNA dysregulation in breast cancer. The study contributes to the understanding of how methylation and copy number alterations influence miRNA expression, emphasizing miRNA functionality through redundant encoding, and suggests novel miRNAs important in breast cancer." -epigenetics hsa-mir-29c Breast Neoplasms 24297604 Dysregulation of microRNA expression drives aberrant DNA hypermethylation in basal-like breast cancer. -epigenetics hsa-mir-199a Chronic Obstructive Pulmonary Disease 24299514 "miR-199a-5p is a key regulator of the unfolded protein response in AAT-deficient monocytes, and epigenetic silencing of its expression regulates this process in chronic obstructive pulmonary disease." -epigenetics hsa-mir-124a Melanoma 24303550 Epigenetic regulation of melanoma tumor suppressor miRNA-124a. -epigenetics hsa-mir-128a "Leukemia, T-Cell" 24316133 Epigenetic regulation of microRNA-128a expression contributes to the apoptosis-resistance of human T-cell leukaemia jurkat cells by modulating expression of fas-associated protein with death domain (FADD). -epigenetics hsa-mir-223 "Carcinoma, Hepatocellular" 24333181 Downregulation of miR-223 in HCC is associated with the epigenetic regulation by highly expressed sulfatide and involved in tumor metastasis. -epigenetics hsa-mir-205 Hepatitis B Virus Infection 24339740 Hepatitis B virus X protein inhibits tumor suppressor miR-205 through inducing hypermethylation of miR-205 promoter to enhance carcinogenesis. -epigenetics hsa-mir-9 Medulloblastoma 24346283 microRNA-9 is a methylation-silenced tumour suppressor that could be a potential candidate predictive marker for poor prognosis of medulloblastoma. -epigenetics hsa-mir-22 Ewing Sarcoma 24362521 The histone demethylase KDM3A is a microRNA-22-regulated tumor promoter in Ewing Sarcoma. -epigenetics hsa-let-7c Cardiomyopathy 24365598 Cardiomyogenesis is controlled by the miR-99a/let-7c cluster and epigenetic modifications. -epigenetics hsa-mir-99a Cardiomyopathy 24365598 Cardiomyogenesis is controlled by the miR-99a/let-7c cluster and epigenetic modifications. -epigenetics hsa-mir-375 "Diabetes Mellitus, Type 2" 24366165 Expression and DNA methylation status of microRNA-375 in patients with type 2 diabetes mellitus. -epigenetics hsa-mir-9 "Leukemia, Lymphocytic, Chronic, B-Cell" 24373626 "Of the miR-9 family, miR-9-3 is a tumor suppressor miRNA relatively frequently methylated, and hence silenced in CLL; whereas miR-9-1 methylation is rare in CLL. The role of miR-9-3 methylation in the constitutive activation of NF¦ÊB signaling pathway in CLL warrants further study." -epigenetics hsa-mir-124a-1 Breast Neoplasms 24375250 "Methylation of miR-124a-1, miR-124a-2, and miR-124a-3 genes correlates with aggressive and advanced breast cancer disease." -epigenetics hsa-mir-124a-2 Breast Neoplasms 24375250 "Methylation of miR-124a-1, miR-124a-2, and miR-124a-3 genes correlates with aggressive and advanced breast cancer disease." -epigenetics hsa-mir-124a-3 Breast Neoplasms 24375250 "Methylation of miR-124a-1, miR-124a-2, and miR-124a-3 genes correlates with aggressive and advanced breast cancer disease." -epigenetics hsa-mir-124 Pulmonary Hypertension 24385500 Deacetylation of MicroRNA-124 in fibroblasts: role in pulmonary hypertension. -epigenetics hsa-mir-297 Squamous Cell Carcinoma 24394434 Phospho-¦¤Np63¦Á/microRNA network modulates epigenetic regulatory enzymes in squamous cell carcinomas. -epigenetics hsa-mir-485 Squamous Cell Carcinoma 24394434 Phospho-¦¤Np63¦Á/microRNA network modulates epigenetic regulatory enzymes in squamous cell carcinomas. -epigenetics hsa-mir-92b Squamous Cell Carcinoma 24394434 Phospho-¦¤Np63¦Á/microRNA network modulates epigenetic regulatory enzymes in squamous cell carcinomas. -epigenetics hsa-mir-34a Bladder Neoplasms 24423412 "Cisplatin-based chemotherapy induced demethylation of miR-34a promoter and increased miR-34a expression, which in turn sensitized MIBC cells to cisplatin and decreased the tumorigenicity and proliferation of cancer cells that by reducing the production of CD44." -epigenetics hsa-let-7a-3 Neoplasms [unspecific] 24423609 Reduction of let-7a3/let-7b miRNA may be one of mechanisms leading to overexpression of HMGA2 in AT/RT tissues. -epigenetics hsa-mir-1258 Lung Neoplasms 24450160 Novel miRNA genes methylated in lung tumors. -epigenetics hsa-mir-137 Lung Neoplasms 24450160 Novel miRNA genes methylated in lung tumors. -epigenetics hsa-mir-375 Lung Neoplasms 24450160 Novel miRNA genes methylated in lung tumors. -epigenetics hsa-mir-21 Pancreatic Neoplasms 24460329 MiR-21 upregulation induced by histone acetylation in the promoter zone is associated with chemoresistance to gemcitabine and enhanced malignant potential in pancreatic cancer cells. -epigenetics hsa-mir-10b Gastric Neoplasms 24481854 "Taken together, these findings suggest that miR-10b may function as a novel tumor suppressor and is partially silenced by DNA hypermethylation in GC." -epigenetics hsa-mir-1260b Prostate Neoplasms 24504368 Our data suggest that genistein exerts its anti-tumour effect via downregulation of miR-1260b that targeted sRRP1 and Smad4 genes in prostate cancer cells. The expression of sFRP1 and Smad4 was also modulated by genistein via DNA methylation or histone modifications in PC cell lines. -epigenetics hsa-mir-203 "Carcinoma, Endometrial" 24530564 "Hypermethylation of miR-203 is a frequent event in endometrial carcinomas and is strongly associated with microsatellite instability and MLH1 methylation status. Thus, miR-203 methylation level might represent a marker for patients with endometrioid and clear endometrial sub-cancers." -epigenetics hsa-mir-34a "Leukemia, Lymphocytic, Chronic, B-Cell" 24559316 "Taken together, miR-34b/c is a tumor suppressor miRNA frequently methylated, and hence silenced in CLL. Together with DAPK1 methylation, miR-34b/c methylation is implicated in the disruption of the TP53-centered tumor suppressor network. Moreover, the association of miRNA methylation warrants further study." -epigenetics hsa-mir-34b "Leukemia, Lymphocytic, Chronic, B-Cell" 24559316 "Taken together, miR-34b/c is a tumor suppressor miRNA frequently methylated, and hence silenced in CLL. Together with DAPK1 methylation, miR-34b/c methylation is implicated in the disruption of the TP53-centered tumor suppressor network. Moreover, the association of miRNA methylation warrants further study." -epigenetics hsa-mir-34c "Leukemia, Lymphocytic, Chronic, B-Cell" 24559316 "Taken together, miR-34b/c is a tumor suppressor miRNA frequently methylated, and hence silenced in CLL. Together with DAPK1 methylation, miR-34b/c methylation is implicated in the disruption of the TP53-centered tumor suppressor network. Moreover, the association of miRNA methylation warrants further study." -epigenetics hsa-mir-375 "Carcinoma, Breast" 24571711 "Epigenetic silencing of miR-375 causes the upregulation of IGF1R,which at least partially underlies trastuzumab resistance of breast cancer cells.Our study has implications for miR-375 as a potential target in combination with trastuzumab for treating HER2-positive breast cancers." -epigenetics hsa-mir-429 "Carcinoma, Hepatocellular" 24572141 "Epigenetic modification of miR-429 can manipulate liver T-ICs by targeting the RBBP4/E2F1/OCT4 axis. This miRNA might be targeted to inactivate T-ICs, thus providing a novel strategy for HCC prevention and treatment." -epigenetics hsa-mir-199b Ovarian Neoplasms 24659709 Epigenetic silencing of microRNA-199b-5p is associated with acquired chemoresistance via activation of JAG1-Notch1 signaling in ovarian cancer. -epigenetics hsa-mir-127 Lung Neoplasms 24665010 Epigenetic analysis of microRNA genes in tumors from surgically resected lung cancer patients and association with survival. -epigenetics hsa-mir-491 Liver Neoplasms 24680928 Arsenic trioxide attenuates the invasion potential of human liver cancer cells through the demethylation-activated microRNA-491. -epigenetics hsa-mir-34 "Leukemia, Lymphocytic, Chronic, B-Cell" 24686393 microRNA-34b/c on chromosome 11q23 is aberrantly methylated in chronic lymphocytic leukemia. -epigenetics hsa-mir-34b "Leukemia, Lymphocytic, Chronic, B-Cell" 24686393 microRNA-34b/c on chromosome 11q23 is aberrantly methylated in chronic lymphocytic leukemia. -epigenetics hsa-mir-34c "Leukemia, Lymphocytic, Chronic, B-Cell" 24686393 microRNA-34b/c on chromosome 11q23 is aberrantly methylated in chronic lymphocytic leukemia. -epigenetics hsa-let-7a-3 "Leukemia, Myeloid, Acute" 24703161 "MicroRNA let-7a-3 gene methylation is associated with karyotyping, CEBPA promoter methylation, and survival in acute myeloid leukemia." -epigenetics hsa-mir-34b "Carcinoma, Hepatocellular" 24704024 Methylation-associated silencing of microRNA-34b in hepatocellular carcinoma cancer. -epigenetics hsa-mir-148a "Carcinoma, Hepatocellular" 24714841 MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in hepatocellular carcinogenesis. -epigenetics hsa-mir-200c Breast Neoplasms 24729530 Induction of the mesenchymal to epithelial transition by demethylation- activated microRNA-200c is involved in the anti-migration/invasion effects of arsenic trioxide on human breast cancer cells. -epigenetics hsa-mir-224 Prostate Neoplasms 24737792 "The GABRE-miR-452-miR-224 locus is downregulated and hypermethylated in prostate cancer and is a new promising epigenetic candidate biomarker for prostate cancer diagnosis and prognosis. Tumor-suppressive functions of the intronic miR-224 and miR-452 were demonstrated in two prostate cancer cell lines,suggesting that epigenetic silencing of GABRE/miR-452/miR-224 may be selected for in prostate cancer." -epigenetics hsa-mir-452 Prostate Neoplasms 24737792 "The GABRE-miR-452-miR-224 locus is downregulated and hypermethylated in prostate cancer and is a new promising epigenetic candidate biomarker for prostate cancer diagnosis and prognosis. Tumor-suppressive functions of the intronic miR-224 and miR-452 were demonstrated in two prostate cancer cell lines,suggesting that epigenetic silencing of GABRE/miR-452/miR-224 may be selected for in prostate cancer." -epigenetics hsa-mir-302 "Carcinoma, Hepatocellular" 24740829 "miR-302-mediated iPSC technology reprogrammed HCC cells and improved drug sensitivity through AOF2 down-regulation, which caused H3K4 methylation and c-Myc repression." -epigenetics hsa-mir-375 "Diabetes Mellitus, Type 2" 24741571 Ethnic differences in microRNA-375 expression level and DNA methylation status in type 2 diabetes of Han and Kazak populations. -epigenetics hsa-mir-31 "Adenocarcinoma, Colon" 24752710 "MicroRNA-31 expression in relation to BRAF mutation, CpG island methylation and colorectal continuum in serrated lesions." -epigenetics hsa-mir-615 "Adenocarcinoma, Pancreatic Ductal" 24769899 miR-615-5p is epigenetically inactivated and functions as a tumor suppressor in pancreatic ductal adenocarcinoma. -epigenetics hsa-mir-449a Gastric Neoplasms 24810364 Long noncoding RNA ANRIL indicates a poor prognosis of gastric cancer and promotes tumor growth by epigenetically silencing of miR-99a/miR-449a. -epigenetics hsa-mir-99a Gastric Neoplasms 24810364 Long noncoding RNA ANRIL indicates a poor prognosis of gastric cancer and promotes tumor growth by epigenetically silencing of miR-99a/miR-449a. -epigenetics hsa-mir-214 Rhabdomyosarcoma 24811402 MiR-214 and N-ras regulatory loop suppresses rhabdomyosarcoma cell growth and xenograft tumorigenesis. -epigenetics hsa-mir-34a "Leukemia, Promyelocytic, Acute" 24811488 "Epigenetic inactivation of DAPK1, p14ARF, mir-34a and -34b/c in acute promyelocytic leukaemia." -epigenetics hsa-mir-34b "Leukemia, Promyelocytic, Acute" 24811488 "Epigenetic inactivation of DAPK1, p14ARF, mir-34a and -34b/c in acute promyelocytic leukaemia." -epigenetics hsa-mir-34c "Leukemia, Promyelocytic, Acute" 24811488 "Epigenetic inactivation of DAPK1, p14ARF, mir-34a and -34b/c in acute promyelocytic leukaemia." -epigenetics hsa-mir-126 Myeloma 24875904 "TNF¦Á in the marrow microenvironment led to RANKL demethylation and re-expression in myeloma cells through DNMT1 repression and upregulation of miR-126-3p and miR-140, both known to repress DNMT1 translation." -epigenetics hsa-mir-140 Myeloma 24875904 "TNF¦Á in the marrow microenvironment led to RANKL demethylation and re-expression in myeloma cells through DNMT1 repression and upregulation of miR-126-3p and miR-140, both known to repress DNMT1 translation." -epigenetics hsa-mir-146a Prostate Neoplasms 24885368 "Up-regulating miR-146a expression via the hypomethylation of the miR-146a promoter by 5-Aza-CdR was correlated with delayed progression of castration-resistant prostate cancers. Moreover, site-specific DNA methylation may play an important role in miR-146a expression in androgen-dependent prostate cancer progression to androgen-independent prostate cancer and therefore provides a potentially useful biomarker for assessing drug efficacy in prostate cancer." -epigenetics hsa-mir-15a "Leukemia, Myeloid, Acute" 24885794 "The DLEU2 locus and embedded miRNA cluster miR-15a/16-1 is commonly deleted in adult cancers and shown to induce leukaemogenesis, however in paediatric AML we found the region to be transcriptionally repressed. In combination, our data highlights the utility of interrogating DNA methylation and microRNA in combination with underlying genetic status to provide novel insights into AML biology." -epigenetics hsa-mir-16-1 "Leukemia, Myeloid, Acute" 24885794 "The DLEU2 locus and embedded miRNA cluster miR-15a/16-1 is commonly deleted in adult cancers and shown to induce leukaemogenesis, however in paediatric AML we found the region to be transcriptionally repressed. In combination, our data highlights the utility of interrogating DNA methylation and microRNA in combination with underlying genetic status to provide novel insights into AML biology." -epigenetics hsa-mir-30b Gastric Neoplasms 24913034 Decreased miR-30b-5p expression by DNMT1 methylation regulation involved in gastric cancer metastasis. -epigenetics hsa-mir-200 Breast Neoplasms 24918286 SUMOylation of FOXM1B alters its transcriptional activity on regulation of MiR-200 family and JNK1 in MCF7 human breast cancer cells. -epigenetics hsa-mir-219 Chronic Inflammatory Pain 25031391 methylation-mediated epigenetic modification of spinal miR-219 expression regulates chronic inflammatory pain by targeting CaMKII¦Ã. -epigenetics hsa-mir-105 Neoplasms [unspecific] 25089631 A novel cancer-germline transcript carrying pro-metastatic miR-105 and TET-targeting miR-767 induced by DNA hypomethylation in tumors. -epigenetics hsa-mir-767 Neoplasms [unspecific] 25089631 A novel cancer-germline transcript carrying pro-metastatic miR-105 and TET-targeting miR-767 induced by DNA hypomethylation in tumors. -epigenetics hsa-mir-145 Chondrosarcoma 25145279 The epigenetic regulation of SOX9 by miR-145 in human chondrosarcoma. -epigenetics hsa-mir-149 Breast Neoplasms 25156775 Methylation-regulated miR-149 modulates chemoresistance by targeting GlcNAc N-deacetylase/N-sulfotransferase-1 in human breast cancer. -epigenetics hsa-mir-320a Breast Neoplasms 25159093 A methylation-based regulatory network for microRNA 320a in chemoresistant breast cancer. -epigenetics hsa-mir-200 Neoplasms [unspecific] 25178837 Zeb1 and Snail1 engage miR-200f transcriptional and epigenetic regulation during EMT. -epigenetics hsa-mir-210 Helicobacter pylori Infection 25187177 Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection. -epigenetics hsa-mir-193a Bladder Neoplasms 25188512 The DNA methylation-regulated miR-193a-3p dictates the multi-chemoresistance of bladder cancer via repression of SRSF2/PLAU/HIC2 expression. -epigenetics hsa-mir-101 Lung Neoplasms 25210796 Restoration of miR-101 suppresses lung tumorigenesis through inhibition of DNMT3a-dependent DNA methylation. -epigenetics hsa-mir-155 "Lymphoma, Non-Hodgkin" 25211095 Methylation of miR-155-3p in mantle cell lymphoma and other non-Hodgkin's lymphomas. -epigenetics hsa-mir-106b Polycystic Ovarian Syndrome 25243570 "Our data suggest that the expression of MCM7 and miR-93/25 is PCOSand IR related, whereas that of miR-106b is related to IR only. In 3T3-L1 adipocytes, neither hyperglycemia nor hyperinsulinemia altered the expression of miR-93 or miR-25, although increasing glucose levels down-regulated MCM7 and paradoxically increased that of miR-106b expression. The expression of the miR-25/93/106b family may be regulated through mechanisms distinct from its host gene, MCM7. Finally, our studies suggest potential epigenetic mechanisms for both IR and PCOS." -epigenetics hsa-mir-25 Polycystic Ovarian Syndrome 25243570 "Our data suggest that the expression of MCM7 and miR-93/25 is PCOSand IR related, whereas that of miR-106b is related to IR only. In 3T3-L1 adipocytes, neither hyperglycemia nor hyperinsulinemia altered the expression of miR-93 or miR-25, although increasing glucose levels down-regulated MCM7 and paradoxically increased that of miR-106b expression. The expression of the miR-25/93/106b family may be regulated through mechanisms distinct from its host gene, MCM7. Finally, our studies suggest potential epigenetic mechanisms for both IR and PCOS." -epigenetics hsa-mir-93 Polycystic Ovarian Syndrome 25243570 "Our data suggest that the expression of MCM7 and miR-93/25 is PCOSand IR related, whereas that of miR-106b is related to IR only. In 3T3-L1 adipocytes, neither hyperglycemia nor hyperinsulinemia altered the expression of miR-93 or miR-25, although increasing glucose levels down-regulated MCM7 and paradoxically increased that of miR-106b expression. The expression of the miR-25/93/106b family may be regulated through mechanisms distinct from its host gene, MCM7. Finally, our studies suggest potential epigenetic mechanisms for both IR and PCOS." -epigenetics hsa-mir-9 Gastric Neoplasms 25270964 Epigenetic silencing of miRNA-9 is correlated with promoter-proximal CpG island hypermethylation in gastric cancer in vitro and in vivo. -epigenetics hsa-mir-148a "Carcinoma, Nasopharyngeal" 25277193 Silencing of miRNA-148a by hypermethylation activates the integrin-mediated signaling pathway in nasopharyngeal carcinoma. -epigenetics hsa-mir-10b Squamous Cell Carcinoma 25312779 Reduction of TIP30 in esophageal squamous cell carcinoma cells involves promoter methylation and microRNA-10b. -epigenetics hsa-mir-24 "Carcinoma, Nasopharyngeal" 25319395 Involvement of microRNA-24 and DNA methylation in resistance of nasopharyngeal carcinoma to ionizing radiation. -epigenetics hsa-mir-129 Gastric Neoplasms 25344911 Methylation of miR-129-5p CpG island modulates multi-drug resistance in gastric cancer by targeting ABC transporters. -epigenetics hsa-mir-214 "Leukemia, Lymphocytic, Chronic, B-Cell" 25361012 "miR-26a and miR-214 down-regulate expression of the PTEN gene in chronic lymphocytic leukemia, but not PTEN mutation or promoter methylation." -epigenetics hsa-mir-26a "Leukemia, Lymphocytic, Chronic, B-Cell" 25361012 "miR-26a and miR-214 down-regulate expression of the PTEN gene in chronic lymphocytic leukemia, but not PTEN mutation or promoter methylation." -epigenetics hsa-mir-34b Breast Neoplasms 25398683 long-term shiftwork may increase the risk of breast cancer via methylation-based suppression of miR-34b and a consequent reduction in immunomediated anti-tumor capacity and support our previous findings that LAN may induce epigenetic alteration of cancer-relevant microRNAs. -epigenetics hsa-mir-142 "Lymphoma, T-Cell" 25405321 These results reveal a subgroup-specific epigenetically regulated microRNA signatures for MFt and CD30+ cALCL patients. -epigenetics hsa-mir-146a "Lymphoma, T-Cell" 25405321 These results reveal a subgroup-specific epigenetically regulated microRNA signatures for MFt and CD30+ cALCL patients. -epigenetics hsa-mir-155 "Lymphoma, T-Cell" 25405321 These results reveal a subgroup-specific epigenetically regulated microRNA signatures for MFt and CD30+ cALCL patients. -epigenetics hsa-mir-181b "Lymphoma, T-Cell" 25405321 These results reveal a subgroup-specific epigenetically regulated microRNA signatures for MFt and CD30+ cALCL patients. -epigenetics hsa-mir-21 "Lymphoma, T-Cell" 25405321 These results reveal a subgroup-specific epigenetically regulated microRNA signatures for MFt and CD30+ cALCL patients. -epigenetics hsa-mir-720 "Leukemia, Myeloid, Acute" 25417880 "The expression of miR-720 in AML patients reduced significantly, and DNA methylation-mediated epigenetic silencing of miR-720 contributed to maintain the malignant characteristics of AML." -epigenetics hsa-mir-34a Colorectal Carcinoma 25422210 "miRNA-34a-5p may play a role as a tumor suppressor gene in colorectal cancer, with involvement of DNA methylation." -epigenetics hsa-mir-106b "Carcinoma, Hepatocellular" 25424171 "DNA methylation plays an important and complex role in the regulation of miRNA expression in HCC, which may provide insights into the pathogenesis of HCC and thus may be used for diagnosis and intervention." -epigenetics hsa-mir-148a "Carcinoma, Hepatocellular" 25424171 "DNA methylation plays an important and complex role in the regulation of miRNA expression in HCC, which may provide insights into the pathogenesis of HCC and thus may be used for diagnosis and intervention." -epigenetics hsa-mir-195 "Carcinoma, Hepatocellular" 25424171 "DNA methylation plays an important and complex role in the regulation of miRNA expression in HCC, which may provide insights into the pathogenesis of HCC and thus may be used for diagnosis and intervention." -epigenetics hsa-mir-23a "Carcinoma, Hepatocellular" 25424171 "DNA methylation plays an important and complex role in the regulation of miRNA expression in HCC, which may provide insights into the pathogenesis of HCC and thus may be used for diagnosis and intervention." -epigenetics hsa-mir-25 "Carcinoma, Hepatocellular" 25424171 "DNA methylation plays an important and complex role in the regulation of miRNA expression in HCC, which may provide insights into the pathogenesis of HCC and thus may be used for diagnosis and intervention." -epigenetics hsa-mir-27a "Carcinoma, Hepatocellular" 25424171 "DNA methylation plays an important and complex role in the regulation of miRNA expression in HCC, which may provide insights into the pathogenesis of HCC and thus may be used for diagnosis and intervention." -epigenetics hsa-mir-375 "Carcinoma, Hepatocellular" 25424171 "DNA methylation plays an important and complex role in the regulation of miRNA expression in HCC, which may provide insights into the pathogenesis of HCC and thus may be used for diagnosis and intervention." -epigenetics hsa-mir-378 "Carcinoma, Hepatocellular" 25424171 "DNA methylation plays an important and complex role in the regulation of miRNA expression in HCC, which may provide insights into the pathogenesis of HCC and thus may be used for diagnosis and intervention." -epigenetics hsa-mir-497 "Carcinoma, Hepatocellular" 25424171 "DNA methylation plays an important and complex role in the regulation of miRNA expression in HCC, which may provide insights into the pathogenesis of HCC and thus may be used for diagnosis and intervention." -epigenetics hsa-mir-93 "Carcinoma, Hepatocellular" 25424171 "DNA methylation plays an important and complex role in the regulation of miRNA expression in HCC, which may provide insights into the pathogenesis of HCC and thus may be used for diagnosis and intervention." -epigenetics hsa-mir-155 Multiple Myeloma 25497370 "DNA methylation contributes to miR-155 expression in myeloma cells. Interestingly, the survival data showed an association between miR-155 expression and outcome of MM." -epigenetics hsa-mir-141 Gastric Neoplasms 25502084 "sion of miR-200c/141 induced by TGF-¦Â in SGC-7901 cells. Our study revealed that miR-200c/141 was downregulated by CpG island methylation and TGF-¦Â signaling, which decreased ZEB1/2 expression and increased E-cadherin expression to inhibit migration and invasion of gastric cancer cells and provides powerful evidence for the application of decitabine in gastric cancer treatment." -epigenetics hsa-mir-155 "Carcinoma, Colon" 25502084 "miR-200c/141 was downregulated by CpG island methylation and TGF-¦Â signaling, which decreased ZEB1/2 expression and increased E-cadherin expression to inhibit migration and invasion of gastric cancer cells and provides powerful evidence for the application of decitabine in gastric cancer treatment." -epigenetics hsa-mir-200 Gastric Neoplasms 25502084 "sion of miR-200c/141 induced by TGF-¦Â in SGC-7901 cells. Our study revealed that miR-200c/141 was downregulated by CpG island methylation and TGF-¦Â signaling, which decreased ZEB1/2 expression and increased E-cadherin expression to inhibit migration and invasion of gastric cancer cells and provides powerful evidence for the application of decitabine in gastric cancer treatment." -epigenetics hsa-mir-490 "Carcinoma, Gastric" 25503559 "hypermethylation-mediated silencing of miR-490-3p reactivates SMARCD1 to confer malignant phenotypes, mechanistically linking H. pylori, chromatin remodeling, and gastric carcinogenesis." -epigenetics hsa-mir-137 Neuroblastoma 25505154 "an epigenetic mechanism involving miR-137-mediated EZH2 repression in RSV-induced apoptosis and tumor suppression of neuroblastoma, which would provide a key potential therapeutic target in neuroblastoma treatment." -epigenetics hsa-mir-21 "Leukemia, Myeloid, Chronic" 25575817 RBP2 epigenetically downregulated miR-21 in blast transformation of CML. -epigenetics hsa-mir-34b Leukemia 25582471 "The hypermethylation of promoter leads to decrease in the expression levels of miR-34b in leukemia cell lines, which attenuate mechanism of proliferative inhibition may be one of the reasons of occurrence or development of childhood leukemia." -epigenetics hsa-mir-328 Osteosarcoma 25605016 the role of RESV-induced molecular and epigenetic regulation in suppressing tumor metastasis. -epigenetics hsa-mir-34b Wilms Tumor 25625843 Epigenetic analysis of sporadic and Lynch-associated ovarian cancers reveals histology-specific patterns of DNA methylation. -epigenetics hsa-mir-142 Systemic Lupus Erythematosus 25661834 "Data from this study suggest that MPA activates miR-142 and miR-146a expression through histone modification at the promoter region, which may partially explain the pharmacological mechanisms of MPA for SLE." -epigenetics hsa-mir-146a Systemic Lupus Erythematosus 25661834 "Data from this study suggest that MPA activates miR-142 and miR-146a expression through histone modification at the promoter region, which may partially explain the pharmacological mechanisms of MPA for SLE." -epigenetics hsa-mir-375 Myeloproliferative Neoplasms 25666256 Epigenetic deregulated miR-375 contributes to the constitutive activation of JAK2/STAT signaling in myeloproliferative neoplasm. -epigenetics hsa-mir-484 Colorectal Carcinoma 25727216 Methylation-induced loss of miR-484 in microsatellite-unstable colorectal cancer promotes both viability and IL-8 production via CD137L. -epigenetics hsa-mir-125b-2 Prostate Neoplasms 25728837 Our work underlined the importance of histone demethylation and DNA oxidation/repairing machinery in androgen-dependent transcription. The present finds have implications for research into new druggable targets for prostate cancer relying on the cascade of AR activity regulation. -epigenetics hsa-mir-133b Prostate Neoplasms 25728837 Our work underlined the importance of histone demethylation and DNA oxidation/repairing machinery in androgen-dependent transcription. The present finds have implications for research into new druggable targets for prostate cancer relying on the cascade of AR activity regulation. -epigenetics hsa-mir-145 Prostate Neoplasms 25749421 A feedback regulation between miR-145 and DNA methyltransferase 3b in prostate cancer cell and their responses to irradiation. -epigenetics hsa-mir-129-2 Glioma 25772485 MiR-129-2 functions as a tumor suppressor in glioma cells by targeting HMGB1 and is down-regulated by DNA methylation. -epigenetics hsa-mir-34b Soft Tissue Sarcoma 25773680 Hypermethylation of potential tumor suppressor miR-34b/c is correlated with late clinical stage in patients with soft tissue sarcomas. -epigenetics hsa-mir-34c Soft Tissue Sarcoma 25773680 Hypermethylation of potential tumor suppressor miR-34b/c is correlated with late clinical stage in patients with soft tissue sarcomas. -epigenetics hsa-mir-101 Glioma 25829251 MiR-101 reverses the hypomethylation of the LMO3 promoter in glioma cells. -epigenetics hsa-mir-9-1 Multiple Myeloma 25855800 "Hypermethylation of miR-9-3 and miR-9-1 is tumour-specific in MM,leading to reversible miRNA silencing. Frequent methylation of miR-9-3 and miR-9-1 in cell lines, but not in primary samples, may be acquired during in vitro culture, and indicates an unimportant role of miR-9 methylation in myelomagenesis." -epigenetics hsa-mir-9-3 Multiple Myeloma 25855800 "Hypermethylation of miR-9-3 and miR-9-1 is tumour-specific in MM,leading to reversible miRNA silencing. Frequent methylation of miR-9-3 and miR-9-1 in cell lines, but not in primary samples, may be acquired during in vitro culture, and indicates an unimportant role of miR-9 methylation in myelomagenesis." -epigenetics hsa-mir-34a Gastric Neoplasms 25860861 Sirt7 promotes gastric cancer growth and inhibits apoptosis by epigenetically inhibiting miR-34a. -epigenetics hsa-mir-124 Prostate Neoplasms 25860954 Regulation and methylation of tumor suppressor miR-124 by androgen receptor in prostate cancer cells. -epigenetics hsa-mir-29b Gastric Neoplasms 25874772 "Deregulation between miR-29b/c and DNMT3A is associated with epigenetic silencing of the CDH1 gene, affecting cell migration and invasion in gastric cancer." -epigenetics hsa-mir-29c Gastric Neoplasms 25874772 "Deregulation between miR-29b/c and DNMT3A is associated with epigenetic silencing of the CDH1 gene, affecting cell migration and invasion in gastric cancer." -epigenetics hsa-mir-24-2 Neoplasms [unspecific] 25943634 The conclusion drawn of hsa-miR-24-2 targeting the genes of cell survival correlated with the methylation profile and resultant transcription factor binding site gain or loss in support of absence of cell survival. -epigenetics hsa-mir-182 Lung Neoplasms 25975295 DNA methylation occurs in the miR-182 promoter region in lung cancer cell lines. This methylation can regulate the expression level of miR-182.Further study must be conducted to explore the function of miR-182 promoter methylation in lung cancer occurrence and development. -epigenetics hsa-mir-34b Neoplasms [unspecific] 25979762 "although results obtained by the different DNA methylation analysis techniques are largely comparable, an appropriate correction may be necessary for stringent comparison." -epigenetics hsa-mir-34c Neoplasms [unspecific] 25979762 "although results obtained by the different DNA methylation analysis techniques are largely comparable, an appropriate correction may be necessary for stringent comparison." -epigenetics hsa-mir-148a Breast Neoplasms 25980823 Glabridin inhibits cancer stem cell-like properties of human breast cancer cells:An epigenetic regulation of miR-148a/SMAd2 signaling. -epigenetics hsa-mir-137 Neoplasms [unspecific] 26066330 We also found that miR-137 and its host gene are epigenetically silenced in human cancer specimens and cell lines.These results support the development and testing of microRNA-based therapies (in particular based on restoring miR-137 levels) for targeting the oncogenic family of p160 SRCs in cancer. -epigenetics hsa-mir-129-2 Lung Neoplasms 26081366 Epigenetic regulation of miR-129-2 and its effects on the proliferation and invasion in lung cancer cells. -epigenetics hsa-mir-302c Chondrosarcoma 26094604 Epigenetic regulation of embryonic stem cell marker miR302C in human chondrosarcoma as determinant of antiproliferative activity of proline-rich polypeptide 1. -epigenetics hsa-mir-10a Atherosclerosis 26148682 "Methylation-specific PCR (MSP) confirmed differential CpG methylation of HOXA genes, the ER stress gene ATF4, inflammatory regulator microRNA-10a and ARHGAP25 that encodes a negative regulator of Rho GTPases involved in cytoskeleton remodeling." -epigenetics hsa-mir-137 Glioblastoma 26187071 Direct transfection of miR-137 mimics is more effective than DNA demethylation of miR-137 promoter to augment anti-tumor mechanisms of delphinidin in human glioblastoma U87MG and LN18 cells. -epigenetics hsa-mir-203 Melanoma 26225581 DNA methylation contributes toward silencing of antioncogenic microRNA-203 in human and canine melanoma cells. -epigenetics hsa-mir-210 Cardiovascular Diseases [unspecific] 26254226 Oxidized low-density lipoprotein is a common risk factor for cardiovascular diseases and gastroenterological cancers via epigenomical regulation of microRNA-210. -epigenetics hsa-mir-145 "Squamous Cell Carcinoma, Esophageal" 26254350 Suppressor microRNA-145 Is Epigenetically Regulated by Promoter Hypermethylation in Esophageal Squamous Cell Carcinoma. -epigenetics hsa-mir-139 "Carcinoma, Lung, Non-Small-Cell" 26256448 Histone methylation-mediated silencing of miR-139 enhances invasion of non-small-cell lung cancer. -epigenetics hsa-let-7 Neoplasms [unspecific] 26303212 Impact of Histone Deacetylase Inhibitors on microRNA Expression and Cancer Therapy: A Review. -epigenetics hsa-mir-106a Neoplasms [unspecific] 26303212 Impact of Histone Deacetylase Inhibitors on microRNA Expression and Cancer Therapy: A Review. -epigenetics hsa-mir-106b Neoplasms [unspecific] 26303212 Impact of Histone Deacetylase Inhibitors on microRNA Expression and Cancer Therapy: A Review. -epigenetics hsa-mir-15a Neoplasms [unspecific] 26303212 Impact of Histone Deacetylase Inhibitors on microRNA Expression and Cancer Therapy: A Review. -epigenetics hsa-mir-16 Neoplasms [unspecific] 26303212 Impact of Histone Deacetylase Inhibitors on microRNA Expression and Cancer Therapy: A Review. -epigenetics hsa-mir-17 Neoplasms [unspecific] 26303212 Impact of Histone Deacetylase Inhibitors on microRNA Expression and Cancer Therapy: A Review. -epigenetics hsa-mir-19b Neoplasms [unspecific] 26303212 Impact of Histone Deacetylase Inhibitors on microRNA Expression and Cancer Therapy: A Review. -epigenetics hsa-mir-148 Hematologic Neoplasms 26314468 "This article summarizes the expression of miR-148/152 family in hematological malignancies, aiming at expounding the signicance of relationship between DNA methylation modification and microRNA." -epigenetics hsa-mir-152 Hematologic Neoplasms 26314468 "This article summarizes the expression of miR-148/152 family in hematological malignancies, aiming at expounding the signicance of relationship between DNA methylation modification and microRNA." -epigenetics hsa-mir-20a Glioma 26337869 "In summary, DNMT1 mediated chemosensitivity by reducing methylation of the microRNA-20a promoter in glioma cells." -epigenetics hsa-mir-125b Neoplasms [unspecific] 26354435 "Taken together, our results demonstrated that miR-125b mediates PAR2-induced cancer cell migration by targeting Gab2 and that NSun2-dependent RNA methylation contributes to the down-regulation of miR-125b by PAR2 signaling. " -epigenetics hsa-let-7 Glioma 26463235 epigenetic modification is a crucial mechanism for controlling the expression of miR-126 in glioma. -epigenetics hsa-mir-126 Rheumatoid Arthritis 26464634 Correlation between miR-126 expression and DNA hypomethylation of CD4+ T cells in rheumatoid arthritis patients. -epigenetics hsa-mir-122 Germ Cell Tumor 26497383 "Cross platform analysis of methylation, miRNA and stem cell gene expression data in germ cell tumors highlights characteristic differences by tumor histology." -epigenetics hsa-mir-302a Germ Cell Tumor 26497383 "Cross platform analysis of methylation, miRNA and stem cell gene expression data in germ cell tumors highlights characteristic differences by tumor histology." -epigenetics hsa-mir-302d Germ Cell Tumor 26497383 "Cross platform analysis of methylation, miRNA and stem cell gene expression data in germ cell tumors highlights characteristic differences by tumor histology." -epigenetics hsa-mir-371 Germ Cell Tumor 26497383 "Cross platform analysis of methylation, miRNA and stem cell gene expression data in germ cell tumors highlights characteristic differences by tumor histology." -epigenetics hsa-mir-373 Germ Cell Tumor 26497383 "Cross platform analysis of methylation, miRNA and stem cell gene expression data in germ cell tumors highlights characteristic differences by tumor histology." -epigenetics hsa-mir-129-2 Breast Neoplasms 26519551 "In summary, the obtained data indicate the involvement of methylation in the down-regulation of the studied coding and miRNA genes and suggest the involvement of miR-129-2 in the deregulation of RASSF1(A) via a direct interaction or/and mediators in common pathways (according to KEGG, Gene Ontology (FDR < 0.01), and GeneCards data) in the examined gynecological tumors." -epigenetics hsa-mir-129-2 Ovarian Neoplasms 26519551 "In summary, the obtained data indicate the involvement of methylation in the down-regulation of the studied coding and miRNA genes and suggest the involvement of miR-129-2 in the deregulation of RASSF1(A) via a direct interaction or/and mediators in common pathways (according to KEGG, Gene Ontology (FDR < 0.01), and GeneCards data) in the examined gynecological tumors." -epigenetics hsa-mir-9-1 Breast Neoplasms 26519551 "In summary, the obtained data indicate the involvement of methylation in the down-regulation of the studied coding and miRNA genes and suggest the involvement of miR-129-2 in the deregulation of RASSF1(A) via a direct interaction or/and mediators in common pathways (according to KEGG, Gene Ontology (FDR < 0.01), and GeneCards data) in the examined gynecological tumors." -epigenetics hsa-mir-9-1 Ovarian Neoplasms 26519551 "In summary, the obtained data indicate the involvement of methylation in the down-regulation of the studied coding and miRNA genes and suggest the involvement of miR-129-2 in the deregulation of RASSF1(A) via a direct interaction or/and mediators in common pathways (according to KEGG, Gene Ontology (FDR < 0.01), and GeneCards data) in the examined gynecological tumors." -epigenetics hsa-mir-34b Leukemia 26524015 "CpG island methylation of miR-34b promoter region in leukemia cell lines can decrease the expression levels of miR-34b, which is also the reason why miR-34b can reduce the inhibition of cell proliferation, thus miR-34b might be a tumor suppressor gene involved in the regulation of leukemia." -epigenetics hsa-mir-29c Breast Neoplasms 26539832 Molecular Subtype-Specific Expression of MicroRNA-29c in Breast Cancer Is Associated with CpG Dinucleotide Methylation of the Promoter. -epigenetics hsa-mir-24 Colon Adenoma 26559563 "Butyrate and partial TSA reduced the expression of miR-135a, miR-135b, miR-24 and miR-let-7a (~0.5-fold, 24 h) and miR-24, miR-106b and miR-let-7a (~0.5-0.7-fold, 48 h) in LT97 cells." -epigenetics hsa-mir-143 Vascular Disease [unspecific] 26573388 "Taken together, these findings suggest that DNMT3a is a direct target of miR-143, and that the upregulation of DNMT3 is responsible for the hypermethylation of miR-143 in Hcy-induced VSMC proliferation." -epigenetics hsa-mir-145 "Adenocarcinoma, Lung" 26582602 "Taken together, DNA hyper-methylation in the miR-145 promoter region reduced its expression in LAC and miR-145 expression level might serve as a novel prognostic biomarker." -epigenetics hsa-mir-218 "Carcinoma, Esophageal" 26610476 "In conclusion, our results support that aberrant CpG hypermethylation at least partly accounts for miR-218 silencing in ESCC, which impairs its tumor-suppressive function." -epigenetics hsa-mir-148a Skin Neoplasms 26638007 "Taken together, the expression of miR-148a was regulated by DNA methylation and targeted by TGIF2.Its methylation may be a potential prognostic indicator in skin cancer." -epigenetics hsa-mir-125a Colorectal Carcinoma 26693202 "Our results suggest that DNA hypermethylation may be involved in the inactivation of miR-125a and miR-125b in CRC, and hypermethylation of miR-125 is a potential biomarker for clinical outcome." -epigenetics hsa-mir-125b Colorectal Carcinoma 26693202 "Our results suggest that DNA hypermethylation may be involved in the inactivation of miR-125a and miR-125b in CRC, and hypermethylation of miR-125 is a potential biomarker for clinical outcome." -epigenetics hsa-mir-34c Colorectal Carcinoma 26704889 "In conclusion, our results suggested the existence of E2F1-miR-34c-SCF negative feedback loop which was interrupted by the hyper-methylation of miR-34c promoter in CRC cells and increased cell proliferation." -epigenetics hsa-mir-140 Osteoarthritis 26723856 "Some miRNA have also been identified and more extensively characterized, such as delineation of the role played by miR-140 in chondrogenesis, followed by the discovery of numerous miRNA potentially involved in the epigenetic regulation of osteoarthritic disease." -epigenetics hsa-mir-21 Colorectal Carcinoma 26787105 This study suggests a high frequency of miR-21 overexpression and aberrant promoter methylation in down-regulation of PTEN expression in colorectal carcinoma. Loss of PTEN may be a prognostic factor for patients with CRC. -epigenetics hsa-mir-133a Cardiomegaly 26830171 Phe exposure led to methylation of CpG sites within the miR-133a locus and reduced miR-133a expression in H9C2 cells -epigenetics hsa-mir-34b Sarcomatoid Mesothelioma 26870271 miR-34b/c was heavily methylated in 2/4 established MPM cell lines -epigenetics hsa-mir-34c Sarcomatoid Mesothelioma 26870271 miR-34b/c was heavily methylated in 2/4 established MPM cell lines -epigenetics hsa-mir-34a Ovarian Neoplasms 26879132 "We demonstrated a clinical independent role of miR-34a in epithelial ovarian cancers. Moreover, we corroborated the correlation between miR-34a expression and its promoter methylation in a large set of ovarian cancers. The inverse association between miR-34a expression and grading, p53 mutation status and dualistic tumor type classification, together with its prognostic relevance may underline the tumor-suppressive character of miR-34a in ovarian cancer." -epigenetics hsa-mir-296 Glioblastoma 26898758 We show that miR-296-5p expression is repressed in a DNA methylation-dependent manner under conditions that promote GBM cell stemness -epigenetics hsa-mir-378 "Leukemia, Myeloid, Chronic" 26913395 Methylation of miR-378 in Chronic Myeloid Leukemia. -epigenetics hsa-mir-181c Glioblastoma 26983574 Epigenetic silencing of miR-181c by DNA methylation in glioblastoma cell lines. -epigenetics hsa-mir-10b "Squamous Cell Carcinoma, Head and Neck" 27002147 DOT1L-associated epigenetic changes induced by HA play pivotal roles in miR-10 production leading to up-regulation of RhoGTPase and survival proteins. -epigenetics hsa-mir-497 Hematologic Neoplasms 27075177 "Strikingly, low-dose decitabine was able to augment chemosensitivity in cancer stem cells, likely by the upregulation of miRNA-497" -epigenetics hsa-mir-155 Lymphoma 27110708 DNA methylation regulates miR-155 expression. -epigenetics hsa-mir-30d Ovarian Neoplasms 27141829 TET3 inhibits TGF-β1-induced epithelial-mesenchymal transition by demethylating miR-30d precursor gene in ovarian cancer cells -epigenetics hsa-mir-193b "Adenocarcinoma, Esophageal" 27176876 Aberrant methylation of microRNA-193b in human Barrett's esophagus and esophageal adenocarcinoma -epigenetics hsa-mir-141 Prostate Neoplasms 27198154 miR-200c and miR-141 are under epigenetic regulation in PCa cells. -epigenetics hsa-mir-200c Prostate Neoplasms 27198154 miR-200c and miR-141 are under epigenetic regulation in PCa cells. -epigenetics hsa-mir-153 Glioblastoma 27215075 MiR-153 as a Tumor Suppressor in Glioblastoma Multiforme is Downregulated by DNA Methylation. -epigenetics hsa-mir-211 Melanoma 27237979 DNMT1 mediated promoter methylation is a mechanism of miRNA suppression in melanoma -epigenetics hsa-mir-200b Cervical Neoplasms 27272214 Long noncoding RNA PVT1 promotes cervical cancer progression through epigenetically silencing miR-200b -epigenetics hsa-mir-27b Breast Neoplasms 27363334 MiR-27b is epigenetically downregulated in tamoxifen resistant breast cancer cells -epigenetics hsa-mir-19a Breast Neoplasms 27445062 "CAP treatment of MCF-7 induced hypermethylation at the promoter CpG sites and downregulation of miR-19a, which was known as an oncomiR." -epigenetics hsa-mir-34a "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 27450916 "Our study revealed that miR-34a promoter hypermethylation was a risk factor for LSCC, played a critical role in the disease progression and metastasis, and could serve as a poor prognostic factor for LSCC." -epigenetics hsa-mir-375 "Carcinoma, Breast" 27466996 "MiR-375 is downregulated in MCF-7/ADM and MCF-7/PTX cells, and its downregulation is a result of promoter methylation." -epigenetics hsa-mir-152 "Carcinoma, Breast" 27475839 DNA methylation and not H3K4 trimethylation dictates the expression status of miR-152 gene which inhibits migration of breast cancer cells via DNMT1/CDH1 loop. -epigenetics hsa-mir-615 "Carcinoma, Hepatocellular" 27487123 "In conclusion, our findings characterize miR-615-5p as an important epigenetically silenced miRNA involved in the Rab-Ras pathway in hepatocellular carcinoma and expand our understanding of the molecular mechanism underlying hepatocarcinogenesis and metastasis." -epigenetics hsa-let-7b "Carcinoma, Colon" 27525719 "G9a binds with and stabilizes RelB, thereby recruiting DNA methyltransferase 3 on the Let-7b promoter and repressing its expression." -epigenetics hsa-mir-34a "Carcinoma, Bladder" 27557899 MicroRNA epigenetic signatures in human disease. -epigenetics hsa-mir-34b Bladder Neoplasms 27557899 MicroRNA epigenetic signatures in human disease. -epigenetics hsa-mir-34c "Carcinoma, Bladder" 27557899 MicroRNA epigenetic signatures in human disease. -epigenetics hsa-mir-125b Chondrosarcoma 27576314 Induction of the mesenchymal to epithelial transition by demethylation-activated microRNA-125b is involved in the anti-migration/invasion effects of arsenic trioxide on human chondrosarcoma. -epigenetics hsa-mir-429 Cholangiocarcinoma 27593557 Cadherin-6 is a putative tumor suppressor and target of epigenetically dysregulated miR-429 in cholangiocarcinoma. -epigenetics hsa-mir-17 Bronchopulmonary Dysplasia 27694474 our data support a plausible role for epigenetically altered miR-17/92 cluster in the pathogenesis of severe BPD -epigenetics hsa-mir-18 Bronchopulmonary Dysplasia 27694474 our data support a plausible role for epigenetically altered miR-17/92 cluster in the pathogenesis of severe BPD -epigenetics hsa-mir-19a Bronchopulmonary Dysplasia 27694474 our data support a plausible role for epigenetically altered miR-17/92 cluster in the pathogenesis of severe BPD -epigenetics hsa-mir-19b-1 Bronchopulmonary Dysplasia 27694474 our data support a plausible role for epigenetically altered miR-17/92 cluster in the pathogenesis of severe BPD -epigenetics hsa-mir-20a Bronchopulmonary Dysplasia 27694474 our data support a plausible role for epigenetically altered miR-17/92 cluster in the pathogenesis of severe BPD -epigenetics hsa-mir-92-1 Bronchopulmonary Dysplasia 27694474 our data support a plausible role for epigenetically altered miR-17/92 cluster in the pathogenesis of severe BPD -epigenetics hsa-mir-200c "Carcinoma, Breast" 27717206 Epigenetic silencing of miR-200c in breast cancer is associated with aggressiveness and is modulated by ZEB1. -epigenetics hsa-mir-200 Ovarian Serous Cystadenocarcinoma 27746113 DNA methylation-regulated microRNA pathways in ovarian serous cystadenocarcinoma: A meta-analysis. -epigenetics hsa-mir-200 "Leukemia, Myeloid, Acute" 27756750 epigenetic silencing of the miR-200 family microRNAs affects ZEB2 expression -epigenetics hsa-mir-124 Cervical Neoplasms 27765948 Suppression of iASPP-dependent aggressiveness in cervical cancer through reversal of methylation silencing of microRNA-124. -epigenetics hsa-mir-126 "Carcinoma, Hepatocellular" 27774652 METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N6 -methyladenosine-dependent primary MicroRNA processing. -epigenetics hsa-mir-149 Glioblastoma 27783537 "MicroRNA-149 is epigenetically silenced tumor-suppressive microRNA, involved in cell proliferation and downregulation of AKT1 and cyclin?D1 in human glioblastoma multiforme." -epigenetics hsa-mir-181a Neurodegenerative Diseases [unspecific] 27789312 PPAR¦Â/¦Ä activation protects against corticosterone-induced ER?stress?in astrocytes by inhibiting the CpG hypermethylation of?microRNA-181a. -epigenetics hsa-mir-124a Rheumatoid Arthritis 27824863 Demethylation of MicroRNA-124a Genes Attenuated Proliferation of Rheumatoid Arthritis Derived Fibroblast-Like Synoviocytes and Synthesis of Tumor Necrosis Factor-¦Á. -epigenetics hsa-mir-107 "Carcinoma, Breast" 27830681 Novel miRNA genes hypermethylated in breast cancer. -epigenetics hsa-mir-1258 "Carcinoma, Breast" 27830681 Novel miRNA genes hypermethylated in breast cancer. -epigenetics hsa-mir-130b "Carcinoma, Breast" 27830681 Novel miRNA genes hypermethylated in breast cancer. -epigenetics hsa-mir-132 "Carcinoma, Breast" 27830681 Novel miRNA genes hypermethylated in breast cancer. -epigenetics hsa-mir-137 "Carcinoma, Breast" 27830681 Novel miRNA genes hypermethylated in breast cancer. -epigenetics hsa-mir-378a Liver Cirrhosis 27855367 The Epigenetically-Regulated microRNA-378a Targets TGF-¦Â2 in TGF-¦Â1-Treated Hepatic Stellate Cells. -epigenetics hsa-mir-148a Osteoporosis 27900532 MiR-148a the epigenetic regulator of bone homeostasis is increased in plasma of osteoporotic postmenopausal women. -epigenetics hsa-mir-124 "Carcinoma, Breast" 27998789 DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression. -epigenetics hsa-mir-125b "Carcinoma, Breast" 27998789 DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression. -epigenetics hsa-mir-127 "Carcinoma, Breast" 27998789 DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression. -epigenetics hsa-mir-132 "Carcinoma, Breast" 27998789 DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression. -epigenetics hsa-mir-137 "Carcinoma, Breast" 27998789 DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression. -epigenetics hsa-mir-148a "Carcinoma, Breast" 27998789 DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression. -epigenetics hsa-mir-191 "Carcinoma, Breast" 27998789 DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression. -epigenetics hsa-mir-193a "Carcinoma, Breast" 27998789 DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression. -epigenetics hsa-mir-203 "Carcinoma, Breast" 27998789 DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression. -epigenetics hsa-mir-212 "Carcinoma, Breast" 27998789 DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression. -epigenetics hsa-mir-34b "Carcinoma, Breast" 27998789 DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression. -epigenetics hsa-mir-375 "Carcinoma, Breast" 27998789 DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression. -epigenetics hsa-mir-9 "Carcinoma, Breast" 27998789 DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression. -epigenetics hsa-mir-149 Hematologic Neoplasms 28035377 Histone deacetylases meet microRNA-associated MMP-9 expression regulation in glucocorticoid-sensitive and -resistant cell lines. -epigenetics hsa-mir-520c Hematologic Neoplasms 28035377 Histone deacetylases meet microRNA-associated MMP-9 expression regulation in glucocorticoid-sensitive and -resistant cell lines. -epigenetics hsa-mir-106b "Adenocarcinoma, Esophageal" 28049580 Epigenetic regulation on the gene expression signature in esophagus adenocarcinoma. -epigenetics hsa-mir-129 "Carcinoma, Urothelial" 28081549 MicroRNA promoter methylation: a new tool for accurate detection of urothelial carcinoma. -epigenetics hsa-mir-663a "Carcinoma, Urothelial" 28081549 MicroRNA promoter methylation: a new tool for accurate detection of urothelial carcinoma. -epigenetics hsa-mir-200 "Carcinoma, Endometrioid Endometrial" 28088687 Whole-Genome DNA Methylation Profiling Identifies Epigenetic Signatures of Uterine Carcinosarcoma. -epigenetics hsa-mir-193b Prostate Neoplasms 28143614 MiR-193b promoter methylation accurately detects prostate cancer in urine sediments and miR-34b/c or miR-129-2 promoter methylation define subsets of clinically aggressive tumors. -epigenetics hsa-mir-371 Testicular Germ Cell Tumor 28199193 Epigenetic and risk factors of testicular germ cell tumors: a brief review. -epigenetics hsa-mir-373 Testicular Germ Cell Tumor 28199193 Epigenetic and risk factors of testicular germ cell tumors: a brief review. -epigenetics hsa-mir-1 Heart Diseases [unspecific] 28209718 Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo. -epigenetics hsa-mir-133 Heart Diseases [unspecific] 28209718 Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo. -epigenetics hsa-mir-208 Heart Diseases [unspecific] 28209718 Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo. -epigenetics hsa-mir-499 Heart Diseases [unspecific] 28209718 Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo. -epigenetics hsa-mir-137 "Carcinoma, Lung, Non-Small-Cell" 28223039 Oncogene LSD1 is epigenetically suppressed by miR-137 overexpression in human non-small cell lung cancer. -epigenetics hsa-mir-183 "Carcinoma, Hepatocellular" 28321157 hsa-mir-183 is frequently methylated and related to poor survival in human hepatocellular carcinoma. -epigenetics hsa-mir-210 Colorectal Carcinoma 28364795 The significance of DNA methylation profile in metastasis-related genes for the progression of colorectal cancer. -epigenetics hsa-mir-34 Colorectal Carcinoma 28364795 The significance of DNA methylation profile in metastasis-related genes for the progression of colorectal cancer. -epigenetics hsa-mir-9 Colorectal Carcinoma 28364795 The significance of DNA methylation profile in metastasis-related genes for the progression of colorectal cancer. -epigenetics hsa-mir-370 Cholangiocarcinoma 28545228 Aberrant DNA Methylation as a Biomarker and a Therapeutic Target of Cholangiocarcinoma. -epigenetics hsa-mir-10b Atherosclerosis 28601079 Variability of Methylation Profiles of CpG Sites in microrNA Genes in Leukocytes and Vascular Tissues of Patients with Atherosclerosis. -epigenetics hsa-mir-200 Lung Neoplasms 28698146 Epigenetic regulation of epithelial-mesenchymal transition by KDM6A histone demethylase in lung cancer cells. -epigenetics hsa-mir-200c Breast Neoplasms 28724364 Tamoxifen reverses epithelial-mesenchymal transition by demethylating miR-200c in triple-negative breast cancer cells. -epigenetics hsa-mir-21 Multiple Sclerosis 28766461 Hypermethylation of MIR21 in CD4+ T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes. -epigenetics hsa-mir-21 Nervous System Diseases [unspecific] 28903050 Changes in the Coding and Non-coding Transcriptome and DNA Methylome that Define the Schwann Cell Repair Phenotype after Nerve Injury. -epigenetics hsa-mir-34a Cholangiocarcinoma 28923203 Epigenetic Silencing of miRNA-34a in Human Cholangiocarcinoma via EZH2 and DNA Methylation: Impact on Regulation of Notch Pathway. -epigenetics hsa-mir-142 "Carcinoma, Hepatocellular" 28963738 Loss-of-function of miR-142 by hypermethylation promotes TGF-¦Â-mediated tumour growth and metastasis in hepatocellular carcinoma. -epigenetics hsa-mir-200b Cervical Neoplasms 29077234 DNA methylation regulated microRNAs in human cervical cancer. -epigenetics hsa-mir-342 Multiple Myeloma 29242101 Epigenetic silencing of EVL/miR-342 in multiple myeloma -epigenetics hsa-mir-101 Glioblastoma 29251856 Studies of intragenic and distant intergenic alterations in DNA methylation will help elucidate the nature of epigenetic deregulation in glioblastoma -epigenetics hsa-mir-29a "Lymphoma, Burkitt" 29318382 methylation-mediated miR-29 epigenetic silencing may occur during BL development -epigenetics hsa-mir-22 Cholangiocarcinoma 29406621 MicroRNA (miR)-433 and miR-22 dysregulations induce histone-deacetylase-6 overexpression and ciliary loss in cholangiocarcinoma. -epigenetics hsa-mir-433 Cholangiocarcinoma 29406621 MicroRNA (miR)-433 and miR-22 dysregulations induce histone-deacetylase-6 overexpression and ciliary loss in cholangiocarcinoma. -epigenetics hsa-mir-196b Prostate Neoplasms 29536528 "CLCA2 epigenetic regulation by CTBP1, HDACs, ZEB1, EP300 and miR-196b-5p impacts prostate cancer cell adhesion and EMT in metabolic syndrome disease." -epigenetics hsa-mir-34a Preeclampsia 29557690 Hypomethylation of the miRNA-34a gene promoter is associated with Severe Preeclampsia -epigenetics hsa-mir-1179 "Carcinoma, Lung, Non-Small-Cell" 29570800 DNA methylation of microRNA-coding genes in non-small-cell lung cancer patients. -epigenetics hsa-mir-148a Prostate Neoplasms 29596883 miR-148a is silenced by DNA methylation and ectopic expression of miR-148a suppresses DNMT1 expression and induced apoptotic genes expression in hormone-refractory prostate cancer cells -epigenetics hsa-mir-375 "Carcinoma, Ovarian" 29631007 Novel miRNA genes deregulated by aberrant methylation in ovarian carcinoma are involved in metastasis -epigenetics hsa-mir-449a "Carcinoma, Pancreatic" 29684857 MicroRNA-449a functions as a tumor suppressor in pancreatic cancer by the epigenetic regulation of ATDC expression. -epigenetics hsa-mir-34c Colorectal Carcinoma 29701273 SATB2 targeted by methylated miR-34c-5p suppresses proliferation and metastasis attenuating the epithelial-mesenchymal transition in colorectal cancer. -epigenetics hsa-mir-483 "Carcinoma, Lung, Non-Small-Cell" 29717264 Epigenetic silencing of miR-483-3p promotes acquired gefitinib resistance and EMT in EGFR-mutant NSCLC by targeting integrin ¦Â3. -epigenetics hsa-mir-570 Osteosarcoma 29795113 Inhibition of LCMR1 and ATG12 by demethylation-activated miR-570-3p is involved in the anti-metastasis effects of metformin on human osteosarcoma. -epigenetics hsa-mir-1271 Gastric Neoplasms 29862663 Epigenetic silencing of miR-1271 enhances MEK1 and TEAD4 expression in gastric cancer. -epigenetics hsa-mir-155 Glioma 29885519 Methylation-mediated miR-155-FAM133A axis contributes to the attenuated invasion and migration of IDH mutant gliomas. -epigenetics hsa-mir-34b Neoplasms [unspecific] 29893976 Regulation of miR-34b/c-targeted gene expression program by SUMOylation. -epigenetics hsa-mir-34c Neoplasms [unspecific] 29893976 Regulation of miR-34b/c-targeted gene expression program by SUMOylation. -epigenetics hsa-mir-34 "Carcinoma, Breast" 29916548 Methylation profiles of miR34 gene family in Vietnamese patients suffering from breast and lung cancers. -epigenetics hsa-mir-137 Endometrial Neoplasms 29955087 miR-137 is a tumor suppressor in endometrial cancer and is repressed by DNA hypermethylation. -epigenetics hsa-mir-124 "Carcinoma, Cervical" 29960712 "Methylation of the hsa-miR-124, SOX1, TERT, and LMX1A genes as biomarkers for precursor lesions in cervical cancer." -epigenetics hsa-mir-145 Ovarian Neoplasms 29993160 Double-negative feedback interaction between DNA methyltransferase 3A and microRNA-145 in the Warburg effect of ovarian cancer cells. -epigenetics hsa-mir-125a Gastric Neoplasms 30117667 Epigenetic silenced miR-125a-5p could be self-activated through targeting Suv39H1 in gastric cancer. -epigenetics hsa-mir-122 "Carcinoma, Hepatocellular" 30195653 LncRNA HOTAIR epigenetically suppresses miR-122 expression in hepatocellular carcinoma via DNA methylation. -epigenetics hsa-mir-4532 "Carcinoma, Breast" 30202238 Downregulation of hypermethylated in cancer-1 by miR-4532 promotes adriamycin resistance in breast cancer cells. -epigenetics hsa-mir-873 Liver Cirrhosis 30237481 MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis. -epigenetics hsa-mir-486 Colorectal Carcinoma 30305607 DNA-methylation-mediated silencing of miR-486-5p promotes colorectal cancer proliferation and migration through activation of PLAGL2/IGF2/¦Â-catenin signal pathways. -epigenetics hsa-mir-388 Gastric Neoplasms 30308487 Hypermethylation of miR-338-3p and Impact of its Suppression on Cell Metastasis Through N-Cadherin Accumulation at the Cell -Cell Junction and Degradation of MMP in Gastric Cancer. -epigenetics hsa-mir-107 Ovarian Neoplasms 30363055 "Hypermethylation of miR-107, miR-130b, miR-203a, miR-1258 Genes Associated with Ovarian Cancer Development and Metastasis" -epigenetics hsa-mir-1258 Ovarian Neoplasms 30363055 "Hypermethylation of miR-107, miR-130b, miR-203a, miR-1258 Genes Associated with Ovarian Cancer Development and Metastasis" -epigenetics hsa-mir-130b Ovarian Neoplasms 30363055 "Hypermethylation of miR-107, miR-130b, miR-203a, miR-1258 Genes Associated with Ovarian Cancer Development and Metastasis" -epigenetics hsa-mir-203a Ovarian Neoplasms 30363055 "Hypermethylation of miR-107, miR-130b, miR-203a, miR-1258 Genes Associated with Ovarian Cancer Development and Metastasis" -epigenetics hsa-mir-132 "Carcinoma, Pancreatic" 30387838 Dexamethasone-induced inhibition of miR-132 via methylation promotes TGF-¦Â-driven progression of pancreatic cancer. -genetics_GWAS hsa-mir-142 Leukemia 15737576 Some human miRNAs are linked to leukemias: the miR-15a/miR-16 locus is frequently deleted or down-regulated in patients with B-cell chronic lymphocytic leukemia and miR-142 is at a translocation site found in a case of aggressive B-cell leukemia. -genetics_GWAS hsa-mir-189 Tourette Syndrome 16224024 we identified a frameshift mutation and two independent occurrences of the identical variant in the binding site for microRNA hsa-miR-189 -genetics_GWAS hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 16251535 mutation -genetics_GWAS hsa-mir-187 "Leukemia, Lymphocytic, Chronic, B-Cell" 16251535 mutation -genetics_GWAS hsa-mir-206 "Leukemia, Lymphocytic, Chronic, B-Cell" 16251535 mutation -genetics_GWAS hsa-mir-27b "Leukemia, Lymphocytic, Chronic, B-Cell" 16251535 mutation -genetics_GWAS hsa-mir-29b-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 16251535 mutation -genetics_GWAS hsa-mir-103a-2 Breast Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-103a-2 Melanoma 16754881 copy number gain -genetics_GWAS hsa-mir-103a-2 Ovarian Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-106b Breast Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-106b Melanoma 16754881 copy number gain -genetics_GWAS hsa-mir-106b Ovarian Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-1-1 Breast Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-1-1 Melanoma 16754881 copy number gain -genetics_GWAS hsa-mir-1-1 Ovarian Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-133a-2 Breast Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-133a-2 Melanoma 16754881 copy number gain -genetics_GWAS hsa-mir-133a-2 Ovarian Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-135b Breast Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-135b Melanoma 16754881 copy number gain -genetics_GWAS hsa-mir-135b Ovarian Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-151a Breast Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-151a Melanoma 16754881 copy number gain -genetics_GWAS hsa-mir-151a Ovarian Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-153-2 Breast Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-153-2 Melanoma 16754881 copy number gain -genetics_GWAS hsa-mir-153-2 Ovarian Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-17 Breast Neoplasms 16754881 copy number loss -genetics_GWAS hsa-mir-17 Melanoma 16754881 copy number loss -genetics_GWAS hsa-mir-17 Ovarian Neoplasms 16754881 copy number loss -genetics_GWAS hsa-mir-18a Breast Neoplasms 16754881 copy number loss -genetics_GWAS hsa-mir-18a Melanoma 16754881 copy number loss -genetics_GWAS hsa-mir-18a Ovarian Neoplasms 16754881 copy number loss -genetics_GWAS hsa-mir-194-1 Breast Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-194-1 Melanoma 16754881 copy number gain -genetics_GWAS hsa-mir-194-1 Ovarian Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-199a-2 Breast Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-199a-2 Melanoma 16754881 copy number gain -genetics_GWAS hsa-mir-199a-2 Ovarian Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-19a Breast Neoplasms 16754881 copy number loss -genetics_GWAS hsa-mir-19a Melanoma 16754881 copy number loss -genetics_GWAS hsa-mir-19a Ovarian Neoplasms 16754881 copy number loss -genetics_GWAS hsa-mir-19b-1 Breast Neoplasms 16754881 copy number loss -genetics_GWAS hsa-mir-19b-1 Melanoma 16754881 copy number loss -genetics_GWAS hsa-mir-19b-1 Ovarian Neoplasms 16754881 copy number loss -genetics_GWAS hsa-mir-200a Breast Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-200a Melanoma 16754881 copy number gain -genetics_GWAS hsa-mir-200a Ovarian Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-200b Breast Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-200b Melanoma 16754881 copy number gain -genetics_GWAS hsa-mir-200b Ovarian Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-20a Breast Neoplasms 16754881 copy number loss -genetics_GWAS hsa-mir-20a Melanoma 16754881 copy number loss -genetics_GWAS hsa-mir-20a Ovarian Neoplasms 16754881 copy number loss -genetics_GWAS hsa-mir-214 Breast Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-214 Melanoma 16754881 copy number gain -genetics_GWAS hsa-mir-214 Ovarian Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-215 Breast Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-215 Melanoma 16754881 copy number gain -genetics_GWAS hsa-mir-215 Ovarian Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-218-1 Breast Neoplasms 16754881 copy number loss -genetics_GWAS hsa-mir-218-1 Melanoma 16754881 copy number loss -genetics_GWAS hsa-mir-218-1 Ovarian Neoplasms 16754881 copy number loss -genetics_GWAS hsa-mir-219-1 Breast Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-219-1 Melanoma 16754881 copy number gain -genetics_GWAS hsa-mir-219-1 Ovarian Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-25 Breast Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-25 Melanoma 16754881 copy number gain -genetics_GWAS hsa-mir-25 Ovarian Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-296 Breast Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-296 Melanoma 16754881 copy number gain -genetics_GWAS hsa-mir-296 Ovarian Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-302a Breast Neoplasms 16754881 copy number loss -genetics_GWAS hsa-mir-302a Melanoma 16754881 copy number loss -genetics_GWAS hsa-mir-302a Ovarian Neoplasms 16754881 copy number loss -genetics_GWAS hsa-mir-302b Breast Neoplasms 16754881 copy number loss -genetics_GWAS hsa-mir-302b Melanoma 16754881 copy number loss -genetics_GWAS hsa-mir-302b Ovarian Neoplasms 16754881 copy number loss -genetics_GWAS hsa-mir-302c Breast Neoplasms 16754881 copy number loss -genetics_GWAS hsa-mir-302c Melanoma 16754881 copy number loss -genetics_GWAS hsa-mir-302c Ovarian Neoplasms 16754881 copy number loss -genetics_GWAS hsa-mir-302d Breast Neoplasms 16754881 copy number loss -genetics_GWAS hsa-mir-302d Melanoma 16754881 copy number loss -genetics_GWAS hsa-mir-302d Ovarian Neoplasms 16754881 copy number loss -genetics_GWAS hsa-mir-30b Breast Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-30b Melanoma 16754881 copy number gain -genetics_GWAS hsa-mir-30b Ovarian Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-30d Breast Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-30d Melanoma 16754881 copy number gain -genetics_GWAS hsa-mir-30d Ovarian Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-320a Breast Neoplasms 16754881 copy number loss -genetics_GWAS hsa-mir-320a Melanoma 16754881 copy number loss -genetics_GWAS hsa-mir-320a Ovarian Neoplasms 16754881 copy number loss -genetics_GWAS hsa-mir-338 Breast Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-338 Melanoma 16754881 copy number gain -genetics_GWAS hsa-mir-338 Ovarian Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-339 Breast Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-339 Melanoma 16754881 copy number gain -genetics_GWAS hsa-mir-339 Ovarian Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-367 Breast Neoplasms 16754881 copy number loss -genetics_GWAS hsa-mir-367 Melanoma 16754881 copy number loss -genetics_GWAS hsa-mir-367 Ovarian Neoplasms 16754881 copy number loss -genetics_GWAS hsa-mir-383 Breast Neoplasms 16754881 copy number loss -genetics_GWAS hsa-mir-383 Melanoma 16754881 copy number loss -genetics_GWAS hsa-mir-383 Ovarian Neoplasms 16754881 copy number loss -genetics_GWAS hsa-mir-429 Breast Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-429 Melanoma 16754881 copy number gain -genetics_GWAS hsa-mir-429 Ovarian Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-488 Breast Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-488 Melanoma 16754881 copy number gain -genetics_GWAS hsa-mir-488 Ovarian Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-9-1 Breast Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-9-1 Melanoma 16754881 copy number gain -genetics_GWAS hsa-mir-9-1 Ovarian Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-93 Breast Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-93 Melanoma 16754881 copy number gain -genetics_GWAS hsa-mir-93 Ovarian Neoplasms 16754881 copy number gain -genetics_GWAS hsa-mir-1 Vascular Hypertrophy 17381315 we have identified an A-to-G transition in the 3'UTR of the GDF8 gene that reveals an illegitimate target site for microRNAs miR-1 and miR-206 that are highly expressed in skeletal muscle. -genetics_GWAS hsa-mir-206 Vascular Hypertrophy 17381315 we have identified an A-to-G transition in the 3'UTR of the GDF8 gene that reveals an illegitimate target site for microRNAs miR-1 and miR-206 that are highly expressed in skeletal muscle. -genetics_GWAS hsa-mir-146a Thyroid Neoplasms 17468766 "somatic mutations altering binding sites for miR-221, miR-222 and miR-146 have been observed in the 3'UTR of the KIT oncogene in papillary thyroid carcinoma." -genetics_GWAS hsa-mir-146b Thyroid Neoplasms 17468766 "somatic mutations altering binding sites for miR-221, miR-222 and miR-146 have been observed in the 3'UTR of the KIT oncogene in papillary thyroid carcinoma." -genetics_GWAS hsa-mir-221 Thyroid Neoplasms 17468766 "somatic mutations altering binding sites for miR-221, miR-222 and miR-146 have been observed in the 3'UTR of the KIT oncogene in papillary thyroid carcinoma." -genetics_GWAS hsa-mir-222 Thyroid Neoplasms 17468766 "somatic mutations altering binding sites for miR-221, miR-222 and miR-146 have been observed in the 3'UTR of the KIT oncogene in papillary thyroid carcinoma." -genetics_GWAS hsa-mir-198 Schizophrenia 17849003 SNP (rs1700) disease susceptibility -genetics_GWAS hsa-mir-206 Schizophrenia 17849003 SNP (rs17578796) disease susceptibility -genetics_GWAS hsa-mir-146a Thyroid Neoplasms 18474871 "Thus, our data suggest that a common polymorphism in pre-miR-146a affects the miR expression, contributes to the genetic predisposition to PTC, and plays a role in the tumorigenesis through somatic mutation." -genetics_GWAS hsa-mir-196a-2 Lung Neoplasms 18521189 "Therefore, the rs11614913 SNP in hsa-mir-196a2 may be a prognostic biomarker for NSCLC." -genetics_GWAS hsa-mir-510 Irritable Bowel Syndrome 18614545 First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor type 3E gene with diarrhea predominant irritable bowel syndrome. -genetics_GWAS hsa-mir-146a Breast Neoplasms 18634034 miR-146: rs2910164 were associated with increased risk of breast cancer in Chinese women -genetics_GWAS hsa-mir-146b Breast Neoplasms 18634034 miR-146: rs2910164 were associated with increased risk of breast cancer in Chinese women -genetics_GWAS hsa-mir-149 Breast Neoplasms 18634034 miR-149: rs2292832 were associated with increased risk of breast cancer in Chinese women -genetics_GWAS hsa-mir-196a-2 Breast Neoplasms 18634034 miR-196a-2: rs11614913 were associated with increased risk of breast cancer in Chinese women -genetics_GWAS hsa-mir-499a Breast Neoplasms 18634034 miR-499: rs3746444 were associated with increased risk of breast cancer in Chinese women -genetics_GWAS hsa-mir-146a Breast Neoplasms 18660546 miR-146a: A functional polymorphism (rs2910164) in the miR-146a gene and age of familial breast/ovarian cancer diagnosis -genetics_GWAS hsa-mir-146a Ovarian Neoplasms 18660546 miR-146a: A functional polymorphism (rs2910164) in the miR-146a gene and age of familial breast/ovarian cancer diagnosis -genetics_GWAS hsa-mir-146a "Carcinoma, Hepatocellular" 18711148 miR-146a: A functional polymorphism (rs2910164) in the miR-146a gene is associated with the risk for hepatocellular carcinoma -genetics_GWAS hsa-mir-659 Dementia 18723524 miR-659: Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia -genetics_GWAS hsa-let-7a "Carcinoma, Lung, Non-Small-Cell" 18922928 A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. -genetics_GWAS hsa-let-7a-1 "Carcinoma, Lung, Non-Small-Cell" 18922928 A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. -genetics_GWAS hsa-let-7a-1 Lung Neoplasms 18922928 let-7a: A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk -genetics_GWAS hsa-let-7a-2 "Carcinoma, Lung, Non-Small-Cell" 18922928 A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. -genetics_GWAS hsa-let-7a-2 Lung Neoplasms 18922928 let-7a: A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk -genetics_GWAS hsa-let-7a-3 "Carcinoma, Lung, Non-Small-Cell" 18922928 A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. -genetics_GWAS hsa-let-7a-3 Lung Neoplasms 18922928 let-7a: A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk -genetics_GWAS hsa-let-7b "Carcinoma, Lung, Non-Small-Cell" 18922928 A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. -genetics_GWAS hsa-let-7b Lung Neoplasms 18922928 let-7b: A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk -genetics_GWAS hsa-let-7c Lung Neoplasms 18922928 let-7c: A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk -genetics_GWAS hsa-let-7d "Carcinoma, Lung, Non-Small-Cell" 18922928 A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. -genetics_GWAS hsa-let-7d Lung Neoplasms 18922928 let-7d: A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk -genetics_GWAS hsa-let-7e Lung Neoplasms 18922928 let-7e: A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk -genetics_GWAS hsa-let-7f-1 Lung Neoplasms 18922928 let-7f: A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk -genetics_GWAS hsa-let-7f-2 Lung Neoplasms 18922928 let-7f: A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk -genetics_GWAS hsa-let-7g "Carcinoma, Lung, Non-Small-Cell" 18922928 A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. -genetics_GWAS hsa-let-7g Lung Neoplasms 18922928 let-7g: A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk -genetics_GWAS hsa-let-7i Lung Neoplasms 18922928 let-7i: A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk -genetics_GWAS hsa-mir-17 Breast Neoplasms 19048628 miR-17: mutations -genetics_GWAS hsa-mir-30c-1 Breast Neoplasms 19048628 miR-30c-1: mutations -genetics_GWAS hsa-mir-122 Hypertension 19067360 a polymorphism of the 3'UTR of the SLC7A1 gene affects the binding with miR-122 -genetics_GWAS hsa-mir-146a Thyroid Neoplasms 19164563 miR-146a: SNP rs2910164 contribute to thyroid cancer -genetics_GWAS hsa-mir-96 Sensorineural Hearing Loss 19363478 miR-96: An ENU-induced mutation -genetics_GWAS hsa-mir-96 Sensorineural Hearing Loss 19363479 miR-96: Mutations in the seed region -genetics_GWAS hsa-mir-128 Anxiety Disorders 19370765 Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders. -genetics_GWAS hsa-mir-148a Anxiety Disorders 19370765 Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders. -genetics_GWAS hsa-mir-148b Anxiety Disorders 19370765 Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders. -genetics_GWAS hsa-mir-152 Anxiety Disorders 19370765 Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders. -genetics_GWAS hsa-mir-485 Anxiety Disorders 19370765 Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders. -genetics_GWAS hsa-mir-509 Anxiety Disorders 19370765 Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders. -genetics_GWAS hsa-mir-765 Anxiety Disorders 19370765 Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders. -genetics_GWAS hsa-mir-125b Breast Neoplasms 19738052 A risk variant in an miR-125b binding site in BMPR1B is associated with breast cancer pathogenesis. -genetics_GWAS hsa-mir-196a-2 Gastric Neoplasms 19834808 miR-196a-2:Association of microRNA-196a-2 gene polymorphism with gastric cancer risk -genetics_GWAS hsa-mir-499 Breast Neoplasms 19847796 "Recently, the SNPs rs11614913 in hsa-mir-196a2 and rs3746444 in hsa-mir-499 were reported to be associated with increased breast cancer risk, and the SNP rs2910164 in hsa-mir-146a was shown to have an effect on age of breast cancer diagnosis." -genetics_GWAS hsa-mir-146a Prostate Neoplasms 19902466 "The natural genetic variation in pre-miR-146a affects the amount of mature miR-146a, contributes to the genetic predisposition to CaP." -genetics_GWAS hsa-mir-15a Multiple Myeloma 20031211 miR-15a:Micro-RNA-15a and micro-RNA-16 expression and chromosome 13 deletions in multiple myeloma -genetics_GWAS hsa-mir-16-1 Multiple Myeloma 20031211 miR-16:Micro-RNA-15a and micro-RNA-16 expression and chromosome 13 deletions in multiple myeloma -genetics_GWAS hsa-mir-16-2 Multiple Myeloma 20031211 miR-16:Micro-RNA-15a and micro-RNA-16 expression and chromosome 13 deletions in multiple myeloma -genetics_GWAS hsa-mir-492 Colorectal Carcinoma 20044760 "mir-492:In a univariate analysis, the progression-free survival of the patients with the combined mir492 C/G and G/G genotype was significantly worse than that of the patients with the mir492 C/C genotype (rs2289030) (P value = 0.0426)" -genetics_GWAS hsa-mir-218-1 Urinary Bladder Cancer 20163849 miR-218:Polymorphisms involved in the miR-218-LAMB3 pathway and susceptibility of cervical cancer -genetics_GWAS hsa-mir-218-2 Urinary Bladder Cancer 20163849 miR-218:Polymorphisms involved in the miR-218-LAMB3 pathway and susceptibility of cervical cancer -genetics_GWAS hsa-mir-191 Ovarian Neoplasms 20167074 Novel genetic variants in miR-191 gene and familial ovarian cancer -genetics_GWAS hsa-mir-196a-2 "Carcinoma, Hepatocellular" 20188135 miR-196a2:MIR196A2 polymorphism was associated with susceptibility to HBV-related HCC in a maleChinese population. -genetics_GWAS hsa-mir-196a-1 Glioma 20229273 A polymorphism of microRNA196a genome region was associated with decreased risk of glioma in Chinese population -genetics_GWAS hsa-mir-196a-2 Glioma 20229273 A polymorphism of microRNA196a genome region was associated with decreased risk of glioma in Chinese population -genetics_GWAS hsa-mir-128-2 "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 20237425 A novel mutation in the miR-128b gene reduces miRNA processing and leads to glucocorticoid resistance of MLL-AF4 acute lymphocytic leukemia cells. -genetics_GWAS hsa-mir-30e Schizophrenia 20347265 miR-30e:mir-30e ss178077483 plays a role in schizophrenia susceptibility -genetics_GWAS hsa-mir-204 Neoplasms [unspecific] 20439436 "miR-204:hsa-miR-30 and hsa-miR-204, were found to be physically altered at the DNA copy number level as well" -genetics_GWAS hsa-mir-20a Neoplasms [unspecific] 20439436 mir-20a:We correctly identified hsa-miR-17/92 family as amplified and the hsa-miR-143/145 cluster as deleted -genetics_GWAS hsa-mir-30a Neoplasms [unspecific] 20439436 "miR-30:hsa-miR-103/106 were downgraded in cancer, whereas hsa-miR-30 became most prominent" -genetics_GWAS hsa-mir-125b-1 "Leukemia, Biphenotypic, Acute" 20485370 miR-125b-1:A new recurrent translocation t(11;14)(q24;q32) involving IGH@ and miR-125b-1 in B-cell progenitor acute lymphoblastic leukemia -genetics_GWAS hsa-mir-196a-2 "Cardiomyopathy, Dilated" 20488170 mir-196a2:Common genetic polymorphisms in pre-microRNAs were associated with increased risk of dilated cardiomyopathy -genetics_GWAS hsa-mir-499a "Cardiomyopathy, Dilated" 20488170 mir-499:Common genetic polymorphisms in pre-microRNAs were associated with increased risk of dilated cardiomyopathy -genetics_GWAS hsa-mir-499 "Squamous Cell Carcinoma, Head and Neck" 20549817 "Of the 4 SNPs that were studied, the hsa-mir-499 AG and GG genotypes were associated with a reduced risk of SCCHN" -genetics_GWAS hsa-mir-30e Schizophrenia 20579744 Our previous study revealed a strong association between the polymorphism ss178077483 in the miRNA-30e precursor (pre-miR-30e) and the risk of SCZ. -genetics_GWAS hsa-mir-126 "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 20621067 miR-126:Alteration of processing induced by a single nucleotide polymorphism in pri-miR-126 -genetics_GWAS hsa-mir-146a Gastrointestinal Neoplasms 20653068 Pre-miR-146a C/G polymorphism might be associated with an elevatedrisk of gastric cancer in Chinese population. -genetics_GWAS hsa-mir-27a Gastric Neoplasms 20666778 mir-27a:mir-27a genetic variant contributes to gastric cancer susceptibility -genetics_GWAS hsa-mir-146a Gastrointestinal Neoplasms 20721625 This study revealed the combined effect of miR-146a rs2910164 G/G and TLR4 +3725 C allele on the increased risk of severe gastric atrophy among the H. pylori-infected Japanese subjects. -genetics_GWAS hsa-mir-155 Hypertension 20966899 "The interplay between miR-155 expression, +1166C polymorphism, and AT1R protein expression may have a role in the regulation of blood pressure." -genetics_GWAS hsa-mir-146a Gastrointestinal Neoplasms 21073609 The rs2910164 (G>C) SNP in the miR-146a is associated with susceptibility to GC. -genetics_GWAS hsa-mir-221 Melanoma 21119596 This KIT variant results in a mismatch in the seed region of a miR-221 complementary site and reporter data suggests that this mismatch can result in increased expression ofthe KIT oncogene. -genetics_GWAS hsa-mir-491 Colorectal Carcinoma 21128281 deleted -genetics_GWAS hsa-mir-646 Colorectal Carcinoma 21128281 deleted -genetics_GWAS hsa-mir-17 Breast Neoplasms 21140207 SNP (rs3739008) located at 3'UTR of NPAS2 and the C to T changing of the SNP may disrupt the binding of microRNA- (miR-)17-5p and miR-519e to the 3'UTR of NPAS2 -genetics_GWAS hsa-mir-519e Breast Neoplasms 21140207 SNP (rs3739008) located at 3'UTR of NPAS2 and the C to T changing of the SNP may disrupt the binding of microRNA- (miR-)17-5p and miR-519e to the 3'UTR of NPAS2 -genetics_GWAS hsa-mir-569 Systemic Lupus Erythematosus 21162035 Association of a functional polymorphism in the 3' untranslated region of SPI1 with systemic lupus erythematosus. -genetics_GWAS hsa-mir-196a-2 Colorectal Carcinoma 21241442 A variant ( rs11614913 ) in microRNA-196a2 is not associated with susceptibility to and progression of colorectal cancer in Chinese. -genetics_GWAS hsa-mir-196a-1 Crohn Disease 21278745 The common exonic synonymous SNP (c.313C>T) in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease. -genetics_GWAS hsa-mir-196a-2 Crohn Disease 21278745 The common exonic synonymous SNP (c.313C>T) in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease. -genetics_GWAS hsa-mir-196b Crohn Disease 21278745 The common exonic synonymous SNP (c.313C>T) in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease. -genetics_GWAS hsa-mir-124-1 Breast Neoplasms 21318219 Genetic variants (SNP rs1042538 A/T) at the miR-124 binding site on the cytoskeleton-organizing IQGAP1 gene confer differential predisposition to breast cancer. -genetics_GWAS hsa-mir-124-2 Breast Neoplasms 21318219 Genetic variants (SNP rs1042538 A/T) at the miR-124 binding site on the cytoskeleton-organizing IQGAP1 gene confer differential predisposition to breast cancer. -genetics_GWAS hsa-mir-124-3 Breast Neoplasms 21318219 Genetic variants (SNP rs1042538 A/T) at the miR-124 binding site on the cytoskeleton-organizing IQGAP1 gene confer differential predisposition to breast cancer. -genetics_GWAS hsa-mir-146a Esophageal Neoplasms 21319225 SNP (rs2910164 G/C): Significantly increased CSCC risks were found to be associated with G allele of rs2910164 -genetics_GWAS hsa-mir-146a "Squamous Cell Carcinoma, Cerevial" 21319225 SNP (rs2910164 G/C): Significantly increased CSCC risks were found to be associated with G allele of rs2910164 -genetics_GWAS hsa-mir-499a Esophageal Neoplasms 21319225 SNP (rs3746444 A/G): Significantly increased CSCC risks were found to be associated with G allele of rs3746444 -genetics_GWAS hsa-mir-499a "Squamous Cell Carcinoma, Cerevial" 21319225 SNP (rs3746444 A/G): Significantly increased CSCC risks were found to be associated with G allele of rs3746444 -genetics_GWAS hsa-mir-196a-2 Urinary Bladder Cancer 21345130 "Our results showed that the heterozygous genotype of rs11614913 (hsa-mir-196a2 C>T rs11614913) was higher in cases than controls but the results were marginally significant (p=0.055; odds ratio, 1.44)." -genetics_GWAS hsa-mir-196b Urinary Bladder Cancer 21345130 "Our results showed that the heterozygous genotype of rs11614913 (hsa-mir-196a2 C>T rs11614913) was higher in cases than controls but the results were marginally significant (p=0.055; odds ratio, 1.44)." -genetics_GWAS hsa-mir-569 Systemic Lupus Erythematosus 21360505 rs1057233 alters a target sequence for microRNA hsa-miR-569 (miR-569). -genetics_GWAS hsa-mir-328 Myopia 21421876 "SNPs rs644242 and rs662702 had marginal significance (p=0.063) and further analyses showed that these SNPs were associated with extreme myopia. The OR for extreme myopia was 2.1 (empirical p=0.007) for the CC genotype at SNP rs662702 at 3' UTR. The functional assay for SNP rs662702 demonstrated that the C allele had a significantly lower expression level than the T allele (P=0.0001). SNP rs662702 was predicted to be located in the microRNA-328 binding site, which may explain the differential allelic effect on gene expression." -genetics_GWAS hsa-let-7a-1 Ovarian Neoplasms 21482675 "rs12194974 (G>A), a SNP in a putative transcription factor binding site in the LIN28B promoter region (summary OR=0.90, 95% CI: 0.82-0.98; P=0.015). LIN28B LIN28B over-expression in epithelial ovarian cancer (EOC) contributes to tumorigenesis by repressing tumor suppressor let-7 expression." -genetics_GWAS hsa-let-7a-2 Ovarian Neoplasms 21482675 "rs12194974 (G>A), a SNP in a putative transcription factor binding site in the LIN28B promoter region (summary OR=0.90, 95% CI: 0.82-0.98; P=0.015). LIN28B LIN28B over-expression in epithelial ovarian cancer (EOC) contributes to tumorigenesis by repressing tumor suppressor let-7 expression." -genetics_GWAS hsa-let-7a-3 Ovarian Neoplasms 21482675 "rs12194974 (G>A), a SNP in a putative transcription factor binding site in the LIN28B promoter region (summary OR=0.90, 95% CI: 0.82-0.98; P=0.015). LIN28B LIN28B over-expression in epithelial ovarian cancer (EOC) contributes to tumorigenesis by repressing tumor suppressor let-7 expression." -genetics_GWAS hsa-mir-196a-2 Breast Neoplasms 21483822 "rs11614913 polymorphism:Overall, individuals with the TC/CC genotypes were associated with higher cancer risk than those with the TT genotype (OR=1.18, 95% CI=1.03-1.34, P<0.001 for heterogeneity test). In the stratified analyses, we observed that the CC genotype might modulate breast cancer risk (OR=1.11, 95%CI=1.01-1.23, P(heterogeneity)=0.210) and lung cancer risk (OR=1.25, 95%CI=1.06-1.46, P(heterogeneity)=0.958), comparing with the TC/TT genotype. Moreover, a significantly increased risk was found among Asian populations in a dominant model (TC/CC versus TT, OR=1.24, 95% CI=1.07-1.43, P(heterogeneity)=0.006)." -genetics_GWAS hsa-mir-196a-2 Lung Neoplasms 21483822 "rs11614913 polymorphism:Overall, individuals with the TC/CC genotypes were associated with higher cancer risk than those with the TT genotype (OR=1.18, 95% CI=1.03-1.34, P<0.001 for heterogeneity test). In the stratified analyses, we observed that the CC genotype might modulate breast cancer risk (OR=1.11, 95%CI=1.01-1.23, P(heterogeneity)=0.210) and lung cancer risk (OR=1.25, 95%CI=1.06-1.46, P(heterogeneity)=0.958), comparing with the TC/TT genotype. Moreover, a significantly increased risk was found among Asian populations in a dominant model (TC/CC versus TT, OR=1.24, 95% CI=1.07-1.43, P(heterogeneity)=0.006)." -genetics_GWAS hsa-mir-146a "Tuberculosis, Pulmonary" 21524676 "A polymorphism (rs2910164 G>C, in miR-146a) indicated an association with PTB risk in both Tibetan (p = 0.031) and Han (p = 0.000) populations. However, the role of the G allele of rs2910164, like the C allele in rs3746444, differed in the Tibetan (OR = 1.509, p < 0.05) and Han (OR = 0.575, p < 0.05) groups." -genetics_GWAS hsa-mir-499a "Tuberculosis, Pulmonary" 21524676 "There was no association between rs3746444 (in hsa-mir-499) and PTB risk (p = 0.118) in the Han population, but subjects carrying the C allele exhibited decreased PTB risk (odds ratio [OR] = 0.403 [95% confidence interval (95% CI) 0.278-0.583]). There was an association between rs3746444 and PTB in the Tibetan population, and individuals carrying the C allele exhibited increased PTB risk (OR = 1.870 [95% CI 1.218-2.871])." -genetics_GWAS hsa-mir-146a Urinary Bladder Cancer 21529907 Polymorphism (rs2910164) of the pre-miR-146a is associated with risk of cervical cancer in a Chinese population. The subjects carrying GG homozygote had a 1.496-foldincreased risk than those carrying CG/CC genotypes. The carriers of GG genotype had obviously more reduced miR-146a expression level compared with the carriers of CC genotype. -genetics_GWAS hsa-mir-137 Melanoma 21543894 miR-137 under expression was significantly associated with melanomas with the KRAS-variant. -genetics_GWAS hsa-mir-125b-1 Prostate Neoplasms 21556765 rs1434536 in the 3'UTR of BMPR1B gene affects the binding ability of miR-125b to BMPR1B mRNA and contributes to the genetic hspredisposition to localized prostate cancer and patients aged >70years. -genetics_GWAS hsa-mir-125b-2 Prostate Neoplasms 21556765 rs1434536 in the 3'UTR of BMPR1B gene affects the binding ability of miR-125b to BMPR1B mRNA and contributes to the genetic hspredisposition to localized prostate cancer and patients aged >70years. -genetics_GWAS hsa-mir-637 Hypertension 21558123 A common genetic variant (rs938671) in the 3'-UTR of Vacuolar H+-ATPase ATP6V0A1 creates a micro-RNA (hsa-miR-637) motif to alter Chromogranin A (CHGA) processing and hypertension risk. -genetics_GWAS hsa-mir-519a-1 Gout 21558165 There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls. There was a significantly increased risk of gout in carriers of the CC genotype.This SNP is homologous to miR-519 and miR-520. -genetics_GWAS hsa-mir-519a-2 Gout 21558165 There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls. There was a significantly increased risk of gout in carriers of the CC genotype.This SNP is homologous to miR-519 and miR-520. -genetics_GWAS hsa-mir-519b Gout 21558165 There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls. There was a significantly increased risk of gout in carriers of the CC genotype.This SNP is homologous to miR-519 and miR-520. -genetics_GWAS hsa-mir-519c Gout 21558165 There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls. There was a significantly increased risk of gout in carriers of the CC genotype.This SNP is homologous to miR-519 and miR-520. -genetics_GWAS hsa-mir-519d Gout 21558165 There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls. There was a significantly increased risk of gout in carriers of the CC genotype.This SNP is homologous to miR-519 and miR-520. -genetics_GWAS hsa-mir-519e Gout 21558165 There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls. There was a significantly increased risk of gout in carriers of the CC genotype.This SNP is homologous to miR-519 and miR-520. -genetics_GWAS hsa-mir-520a Gout 21558165 There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls. There was a significantly increased risk of gout in carriers of the CC genotype.This SNP is homologous to miR-519 and miR-520. -genetics_GWAS hsa-mir-520b Gout 21558165 There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls. There was a significantly increased risk of gout in carriers of the CC genotype.This SNP is homologous to miR-519 and miR-520. -genetics_GWAS hsa-mir-520d Gout 21558165 There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls. There was a significantly increased risk of gout in carriers of the CC genotype.This SNP is homologous to miR-519 and miR-520. -genetics_GWAS hsa-mir-520e Gout 21558165 There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls. There was a significantly increased risk of gout in carriers of the CC genotype.This SNP is homologous to miR-519 and miR-520. -genetics_GWAS hsa-mir-520f Gout 21558165 There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls. There was a significantly increased risk of gout in carriers of the CC genotype.This SNP is homologous to miR-519 and miR-520. -genetics_GWAS hsa-mir-520g Gout 21558165 There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls. There was a significantly increased risk of gout in carriers of the CC genotype.This SNP is homologous to miR-519 and miR-520. -genetics_GWAS hsa-mir-520h Gout 21558165 There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls. There was a significantly increased risk of gout in carriers of the CC genotype.This SNP is homologous to miR-519 and miR-520. -genetics_GWAS hsa-mir-196a-2 Chronic Obstructive Pulmonary Disease 21565178 "The TT genotype and T allele of miR-196a2 rs11614913 were significantly associated with a decreased risk for COPD (Chronic obstructive pulmonary disease), compared with the CC genotype and C allele. Similarly, the GG genotype and G allele of miR-499 rs3746444 were associated with a decreased risk for COPD, compared with the AA genotype and A allele." -genetics_GWAS hsa-mir-499a Chronic Obstructive Pulmonary Disease 21565178 "The TT genotype and T allele of miR-196a2 rs11614913 were significantly associated with a decreased risk for COPD (Chronic obstructive pulmonary disease), compared with the CC genotype and C allele. Similarly, the GG genotype and G allele of miR-499 rs3746444 were associated with a decreased risk for COPD, compared with the AA genotype and A allele." -genetics_GWAS hsa-mir-196a-2 Colorectal Carcinoma 21565628 A Functional Variant in MicroRNA-196a2 (rs11614913 SNP) Is Associated with Susceptibility of Colorectal Cancer in a Chinese Population. -genetics_GWAS hsa-mir-1302-1 Male Infertility 21601192 "Two SNPs from two genes (rs6631 of CGA and rs2303846 of CPEB1)(binding sites of miR-1302) were found to be associated with idiopathic male infertility. Functionally, the substitution of A by T in rs6631 results in decreased binding affinity of miR-1302 and overexpression of CGA in vitro." -genetics_GWAS hsa-mir-1302-2 Male Infertility 21601192 "Two SNPs from two genes (rs6631 of CGA and rs2303846 of CPEB1)(binding sites of miR-1302) were found to be associated with idiopathic male infertility. Functionally, the substitution of A by T in rs6631 results in decreased binding affinity of miR-1302 and overexpression of CGA in vitro." -genetics_GWAS hsa-mir-1302-3 Male Infertility 21601192 "Two SNPs from two genes (rs6631 of CGA and rs2303846 of CPEB1)(binding sites of miR-1302) were found to be associated with idiopathic male infertility. Functionally, the substitution of A by T in rs6631 results in decreased binding affinity of miR-1302 and overexpression of CGA in vitro." -genetics_GWAS hsa-mir-1302-4 Male Infertility 21601192 "Two SNPs from two genes (rs6631 of CGA and rs2303846 of CPEB1)(binding sites of miR-1302) were found to be associated with idiopathic male infertility. Functionally, the substitution of A by T in rs6631 results in decreased binding affinity of miR-1302 and overexpression of CGA in vitro." -genetics_GWAS hsa-mir-1302-5 Male Infertility 21601192 "Two SNPs from two genes (rs6631 of CGA and rs2303846 of CPEB1)(binding sites of miR-1302) were found to be associated with idiopathic male infertility. Functionally, the substitution of A by T in rs6631 results in decreased binding affinity of miR-1302 and overexpression of CGA in vitro." -genetics_GWAS hsa-mir-1302-6 Male Infertility 21601192 "Two SNPs from two genes (rs6631 of CGA and rs2303846 of CPEB1)(binding sites of miR-1302) were found to be associated with idiopathic male infertility. Functionally, the substitution of A by T in rs6631 results in decreased binding affinity of miR-1302 and overexpression of CGA in vitro." -genetics_GWAS hsa-mir-1302-7 Male Infertility 21601192 "Two SNPs from two genes (rs6631 of CGA and rs2303846 of CPEB1)(binding sites of miR-1302) were found to be associated with idiopathic male infertility. Functionally, the substitution of A by T in rs6631 results in decreased binding affinity of miR-1302 and overexpression of CGA in vitro." -genetics_GWAS hsa-mir-1302-8 Male Infertility 21601192 "Two SNPs from two genes (rs6631 of CGA and rs2303846 of CPEB1)(binding sites of miR-1302) were found to be associated with idiopathic male infertility. Functionally, the substitution of A by T in rs6631 results in decreased binding affinity of miR-1302 and overexpression of CGA in vitro." -genetics_GWAS hsa-mir-196a-2 Hepatitis C Virus Infection 21604580 SNP rs11614913 on miR196a-2 gene is associated with the antiviral therapy efficacy of hepatitis C patients.The TT genotype or T alleles be associated with the SVR while the CC genotype or C allele could be related to the NVR or recurrence. -genetics_GWAS hsa-mir-196a-2 "Carcinoma, Lung, Non-Small-Cell" 21617338 MicroRNA196a2 rs11614913 Genotypes are associated with the Risk of Non-Small Cell Lung Cancer in Korean Population. -genetics_GWAS hsa-mir-146a Gastric Neoplasms 21632853 "miR-146a levels in cancer tissues were significantly lower than those in the corresponding noncancerous tissue. Lower levels of miR-146a were associated with lymph node metastasis and venous invasion. Moreover, a lower level of miR-146a was an independent prognostic factor for overall survival.Ectopic expression of miR-146a inhibited migration and invasion and downregulated EGFR and IRAK1 expression in gastric cancer cells. In addition, G/C SNP within the pre-miR-146a seed sequence significantly reduced miR-146a levels in the GG genotype compared with the CC genotype." -genetics_GWAS hsa-mir-492 Psoriasis 21655935 "The rs8259 T allele was associated with significantly decreased psoriasis susceptibility (OR=0.758, 95% CI 0.638-0.901, p=0.002) compared to A allele. the rs8259 polymorphism was located in a seed region for miR-492 binding." -genetics_GWAS hsa-mir-1827 "Carcinoma, Lung, Small-Cell" 21676885 "Genetic Variation in an miRNA-1827 Binding Site in MYCL1 Alters Susceptibility to Small-Cell Lung Cancer. The rs3134615T allele was associated with a significantly increased risk of SCLC, with the OR for carrying the GT or TT genotype being 2.08 (95% confidence interval, 1.39-3.21; P = 0.0004) compared with the GG genotype." -genetics_GWAS hsa-mir-146a Systemic Lupus Erythematosus 21738483 A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus. -genetics_GWAS hsa-mir-146a Glioblastoma 21744077 "A functional polymorphism in the pre-miR-146a gene is associated with risk and prognosis in adult glioma. An increased glioma risk was observed among rs2910164 minor allele (C) carriers (per allele OR (95%CI)=1.22 (1.01-1.46, p (trend)=0.039)). The association was stronger among older subjects carrying at least one copy of the C allele (OR (95% CI)=1.38 (1.04-1.83, P=0.026). Mortality was increased among minor allele carriers (HR(95% CI)=1.33 (1.03-1.72, P=0.029)), with the association largely restricted to females (HR (95% CI)=2.02 (1.28-3.17, P=0.002))." -genetics_GWAS hsa-mir-101 "Carcinoma, Ovarian" 21765906 "a few of which have been found in the genomic fragile regions that are associated with abnormal deletion or amplification in cancer, such as miR-21, miR-101-1, miR-210 and miR-301a." -genetics_GWAS hsa-mir-21 "Carcinoma, Ovarian" 21765906 "a few of which have been found in the genomic fragile regions that are associated with abnormal deletion or amplification in cancer, such as miR-21, miR-101-1, miR-210 and miR-301a." -genetics_GWAS hsa-mir-210 "Carcinoma, Ovarian" 21765906 "a few of which have been found in the genomic fragile regions that are associated with abnormal deletion or amplification in cancer, such as miR-21, miR-101-1, miR-210 and miR-301a." -genetics_GWAS hsa-mir-301a "Carcinoma, Ovarian" 21765906 "a few of which have been found in the genomic fragile regions that are associated with abnormal deletion or amplification in cancer, such as miR-21, miR-101-1, miR-210 and miR-301a." -genetics_GWAS hsa-mir-155 Hypertrophy 21771600 the C allele of rs5186 was associated with a significant increase in SWT (p=0.003) and LVM (p=0.001). This functional polymorphism increases expression of AGTR1 by altering the binding site for miR-155 -genetics_GWAS hsa-mir-125a Habitual Abortion 21788734 "Two common SNPs (rs41275794, rs12976445) in pri-miR-125a alter the mature miRNA expression and associate with Abortion, Habitual in a Han-Chinese population." -genetics_GWAS hsa-mir-367 Breast Neoplasms 21810988 "Functional SNP (rs1044129, is present in binding region) in the microRNA-367 binding site in the 3'UTR of the calcium channel ryanodine receptor gene 3 (RYR3) affects breast cancer risk and calcification." -genetics_GWAS hsa-mir-196a-2 Colorectal Carcinoma 21815818 A Functional Polymorphism (rs11614913 (T>C)) in miRNA-196a2 Is Associated with Colorectal Cancer Risk in a Chinese Population. -genetics_GWAS hsa-mir-542 Colorectal Carcinoma 21822307 A common single-nucleotide polymorphism (T8473CA) in cyclooxygenase-2 disrupts microRNA (miR-542-3p)-mediated regulation. -genetics_GWAS hsa-mir-637 Hypertension 21846868 ATP6V0A1 Polymorphism and MicroRNA-637 may have A Pathogenetic Role for MicroRNAs in Essential Hypertension. -genetics_GWAS hsa-mir-146a "Carcinoma, Lung, Non-Small-Cell" 21902575 CG genotype of miR-146a(rs2910164 C-G) appeared associated to an increased risk for NSCLC (p=0.042 and 1.77 OR). -genetics_GWAS hsa-mir-146b "Carcinoma, Lung, Non-Small-Cell" 21902575 CG genotype of miR-146a(rs2910164 C-G) appeared associated to an increased risk for NSCLC (p=0.042 and 1.77 OR). -genetics_GWAS hsa-mir-196a-2 "Carcinoma, Lung, Non-Small-Cell" 21902575 "The authors clearly detected a significant increase (p<0.001) of miR-196a2 expression in NSCLC. In particular the authors found a significant association between miR-196a2 (rs11614913 C-T) CC genotype and high expression, whereas TT genotype showed a very low expression in comparison to both CT (p<0.005) and CC patients (p<0.01)." -genetics_GWAS hsa-mir-137 Schizophrenia 21926974 "GWAS analysis revealed that rs1625579 within an intron of a putative primary transcript for MIR137 (microRNA 137), a known regulator of neuronal development was associated with schizophrenia." -genetics_GWAS hsa-mir-184 "Squamous Cell Carcinoma, Head and Neck" 21934093 "The authors found that, compared with the rs8126 TT (a SNP of miR-184 Binding Site in TNFAIP2) genotype, the variant C allele were associated with increased SCCHN risk in an allele-dose response manner (adjusted odds ratio=1.48 and 95% confidence interval=1.06-2.05 for CC, respectively; P(trend)=0.009)." -genetics_GWAS hsa-mir-149 Gastric Neoplasms 21976437 "Marginally significant associations were found both for hsa-miR-149 rs2292832 with gastric cancer risk (TC+CC vs. TT, OR=0.68, 95% CI: 0.44-1.04) and for hsa-miR-605 rs2043556 with colorectal cancer risk (AG+GG vs. AA, OR=0.70, 95% CI: 0.48-1.02) in males." -genetics_GWAS hsa-mir-605 Gastric Neoplasms 21976437 "Marginally significant associations were found both for hsa-miR-149 rs2292832 with gastric cancer risk (TC+CC vs. TT, OR=0.68, 95% CI: 0.44-1.04) and for hsa-miR-605 rs2043556 with colorectal cancer risk (AG+GG vs. AA, OR=0.70, 95% CI: 0.48-1.02) in males." -genetics_GWAS hsa-mir-146a Thyroid Neoplasms 21978540 "Despite some limitations, this meta-analysis suggests that the miR-146a G allele is a low-penetrant risk factor for papillary thyroid carcinoma development." -genetics_GWAS hsa-mir-218-1 "Carcinoma, Hepatocellular" 22011248 "The AG genotype of pri-miR-218 rs11134527 A/G was associated with family history (p=0.018, odds ratio [OR]=2.96, 95% confidence interval [CI]: 1.16-7.56) and elevated serum alpha-fetoprotein (serum alpha-fetoprotein [AFP]) levels (¡Ý20 ng/mL; p=0.009, OR=1.92, 95% CI: 1.17-3.14) in HCC patients. These findings suggested that the AG genotype of pri-miR-218 rs11134527 might relate to genetic predisposition and be involved in regulating the expression of AFP in Chinese HCC patients." -genetics_GWAS hsa-mir-218-2 "Carcinoma, Hepatocellular" 22011248 "The AG genotype of pri-miR-218 rs11134527 A/G was associated with family history (p=0.018, odds ratio [OR]=2.96, 95% confidence interval [CI]: 1.16-7.56) and elevated serum alpha-fetoprotein (serum alpha-fetoprotein [AFP]) levels (¡Ý20 ng/mL; p=0.009, OR=1.92, 95% CI: 1.17-3.14) in HCC patients. These findings suggested that the AG genotype of pri-miR-218 rs11134527 might relate to genetic predisposition and be involved in regulating the expression of AFP in Chinese HCC patients." -genetics_GWAS hsa-mir-499a Rheumatoid Arthritis 22019503 "There was a significant difference in the levels of CRP and ESR among different genotypes in rs3746444 (hsa-mir-499) (p = 0.031 and p = 0.047, respectively) in Chinese Han people. The heterozygote CT had significantly higher levels of CRP and ESR compared with homozygotes CC and TT." -genetics_GWAS hsa-mir-423 Colorectal Carcinoma 22028396 "Two SNPs were identified to be significantly associated with recurrence-free survival and overall survival of the patients. The most significant SNP was rs6505162 in pre-miR-423. Compared to the homozygous wild-type genotype, the variant-containing genotypes of this SNP were significantly associated with both the overall survival (HR=2.12, 95% CI1.34--3.34, P=0.001) and the recurrence-free survival (HR=1.59, 95% CI1.08--2.36, P=0.019). Another SNP, rs4919510 in pre-miR-608, was also associated with altered recurrence-free survival (HR=0.61, 95% CI 0.41-0.92, P=0.017). These effects were evident only in patients receiving chemotherapy but not in those without chemotherapy. In addition, the combined analysis of the two SNPs conferred a 2.84-fold (95% CI 1.50-5.37, P=0.001) increased risk of recurrence and/or death. Similarly, this effect was only prominent in those receiving chemotherapy (P<0.001) but not in those without chemotherapy (P=0.999)." -genetics_GWAS hsa-mir-608 Colorectal Carcinoma 22028396 "Two SNPs were identified to be significantly associated with recurrence-free survival and overall survival of the patients. The most significant SNP was rs6505162 in pre-miR-423. Compared to the homozygous wild-type genotype, the variant-containing genotypes of this SNP were significantly associated with both the overall survival (HR=2.12, 95% CI1.34--3.34, P=0.001) and the recurrence-free survival (HR=1.59, 95% CI1.08--2.36, P=0.019). Another SNP, rs4919510 in pre-miR-608, was also associated with altered recurrence-free survival (HR=0.61, 95% CI 0.41-0.92, P=0.017). These effects were evident only in patients receiving chemotherapy but not in those without chemotherapy. In addition, the combined analysis of the two SNPs conferred a 2.84-fold (95% CI 1.50-5.37, P=0.001) increased risk of recurrence and/or death. Similarly, this effect was only prominent in those receiving chemotherapy (P<0.001) but not in those without chemotherapy (P=0.999)." -genetics_GWAS hsa-mir-196a-2 Breast Neoplasms 22074121 "The Chinese women with menarche age less than 16 years had increased breast cancer risk (OR = 2.10, 95% CI: 1.23-3.60). Marginally significant association between rs11614913 (hsa-miR-196a-2) CT/CC genotypes and reduced breast cancer risk was observed (OR = 0.65, 95% CI: 0.40-1.06)," -genetics_GWAS hsa-mir-502 "Carcinoma, Hepatocellular" 22095217 "We analysed a single nucleotide polymorphism (rs16917496) within the miR-502 microRNA seed region for the 3' UTR of SET8 in Chinese hepatocellular carcinoma (HCC) patients. The SET8 CC genotype was independently associated with longer post-operative survival in HCC patients by multivariate analysis (relative risk, 0.175; 95% CI, 0.053 - 0.577; p = 0.004). The SET8 CC genotype was associated with reduced SET8 protein levels based on the immunostaining of 51 HCC tissue samples. We also found the low SET8 levels was associated with longer HCC survival. Our data suggest that SET8 modifies HCC outcome by altering its expression, which depends, at least in part, on its binding affinity with miR502." -genetics_GWAS hsa-mir-30c-1 Gastric Neoplasms 22108846 "The genotype frequencies of pre-miR-30c A/G (Polymorphism rs928508 in pre-miR-30c) in gastric cancer patients were obviously different from those in the controls (P = 0.022). AA genotype carriers were associated with an increased risk of gastric cancer compared with GG genotype (adjusted odds ratio (OR) = 1.83, 95% confidence interval (CI): 1.07-3.15, P = 0.029). Moreover, the gastric cancer risk especially elevated in older individuals (aged >60 years), males, nonsmokers, and Helicobacter pylori (H. pylori)-infected individuals (adjusted OR = 2.66, 95% CI: 1.38-5.13, P = 0.004; adjusted OR = 1.90, 95% CI: 1.10-3.27, P = 0.022; adjusted OR = 1.94, 95% CI: 1.12-3.35, P = 0.018; adjusted OR = 1.83, 95% CI: 1.08-3.10, P = 0.024, respectively). Further stratified analysis indicated that AA genotype facilitated developing of gastric cancer with lymph node metastasis (adjusted OR = 2.23, 95% CI: 1.07-4.64, P = 0.032). Expression analysis detected that rs928508 AA showed a significantly increased level of mature miR-30c compared with GG or AG/GG genotype (P = 0.011 or P = 0.013). Patients with AA genotype were associated with unfavorable outcome in overall survival compared with AG/GG genotype (Log rank 5.848, P = 0.016). This study demonstrates that pre-miR-30c A/G polymorphism may be associated with an increased risk of gastric cancer in a Chinese population through altering mature miR-30c expression." -genetics_GWAS hsa-mir-30c-2 Gastric Neoplasms 22108846 "The genotype frequencies of pre-miR-30c A/G (Polymorphism rs928508 in pre-miR-30c) in gastric cancer patients were obviously different from those in the controls (P = 0.022). AA genotype carriers were associated with an increased risk of gastric cancer compared with GG genotype (adjusted odds ratio (OR) = 1.83, 95% confidence interval (CI): 1.07-3.15, P = 0.029). Moreover, the gastric cancer risk especially elevated in older individuals (aged >60 years), males, nonsmokers, and Helicobacter pylori (H. pylori)-infected individuals (adjusted OR = 2.66, 95% CI: 1.38-5.13, P = 0.004; adjusted OR = 1.90, 95% CI: 1.10-3.27, P = 0.022; adjusted OR = 1.94, 95% CI: 1.12-3.35, P = 0.018; adjusted OR = 1.83, 95% CI: 1.08-3.10, P = 0.024, respectively). Further stratified analysis indicated that AA genotype facilitated developing of gastric cancer with lymph node metastasis (adjusted OR = 2.23, 95% CI: 1.07-4.64, P = 0.032). Expression analysis detected that rs928508 AA showed a significantly increased level of mature miR-30c compared with GG or AG/GG genotype (P = 0.011 or P = 0.013). Patients with AA genotype were associated with unfavorable outcome in overall survival compared with AG/GG genotype (Log rank 5.848, P = 0.016). This study demonstrates that pre-miR-30c A/G polymorphism may be associated with an increased risk of gastric cancer in a Chinese population through altering mature miR-30c expression." -genetics_GWAS hsa-mir-629 Lung Neoplasms 22114071 "The rs2735383CC (NBS1 gene) genotype had a significantly increased risk of lung cancer under a recessive genetic model in the total 1559 cases versus 1679 controls (OR = 1.40, 95% C.I. = 1.18-1.66, P = 0.0001) when compared with GG or GC genotypes; the rs2735383CC genotype carriers had lower mRNA and protein expression levels in tumor tissues than those of other genotypes as qPCR and western blot shown. Luciferase assay revealed that the rs2735383C allele had a lower transcription activity than G allele; and the hsa-miR-629 but not hsa-miR-499-5P had effect on modulation of NBS1 gene in vitro. We further observed that the X-ray radiation induced more chromatid breaks in lymphocyte cells from the carriers of rs2735383CC homozygote than those from the subjects with other genotypes (P = 0.0008). Our data suggested that the rs2735383G>C variation contributes to an increased risk of lung cancer by diminishing gene's expression through binding of microRNA-629 to the polymorphic site in the 3'-UTR of NBS1 gene." -genetics_GWAS hsa-mir-196a-2 Coronary Artery Disease 22159951 "The variant genotypes CC/CT of hsa-mir-196a2 rs11614913 T ¡ú C were not associated with a significantly increased risk of CAD (adjusted OR = 1.02, 95% CI = 0.76-1.38), compared with wide genotype TT, but CC and CC/CT genotypes were associated with 34 and 35% increased risks of serious prognosis of CAD (adjusted HR = 1.34, 95% CI = 1.02-1.75 for CC; adjusted HR = 1.35, 95% CI = 1.03-1.75 for CC/CT). In the variant of hsa-mir-499 rs3746444A ¡ú G, GG was associated with the 223% increased risk of CAD (adjusted OR = 3.23, 95% CI = 1.56-6.67). Cox regression analysis showed that age, smoking status, numbers of pathological changes in coronary arteries, rs11614913 T ¡ú C, and diabetes mellitus were associated with serious prognosis of CAD." -genetics_GWAS hsa-mir-499a Coronary Artery Disease 22159951 "The variant genotypes CC/CT of hsa-mir-196a2 rs11614913 T ¡ú C were not associated with a significantly increased risk of CAD (adjusted OR = 1.02, 95% CI = 0.76-1.38), compared with wide genotype TT, but CC and CC/CT genotypes were associated with 34 and 35% increased risks of serious prognosis of CAD (adjusted HR = 1.34, 95% CI = 1.02-1.75 for CC; adjusted HR = 1.35, 95% CI = 1.03-1.75 for CC/CT). In the variant of hsa-mir-499 rs3746444A ¡ú G, GG was associated with the 223% increased risk of CAD (adjusted OR = 3.23, 95% CI = 1.56-6.67). Cox regression analysis showed that age, smoking status, numbers of pathological changes in coronary arteries, rs11614913 T ¡ú C, and diabetes mellitus were associated with serious prognosis of CAD." -genetics_GWAS hsa-mir-196a-2 Colorectal Carcinoma 22161766 The authors found a significantly increased colorectal cancer risk with the miR-196a2CC (rs11614913) genotype compared with the TT/CT genotype (AOR=1.50; 95% CI=1.11-2.04; P=0.01; FDR-P=0.04) in Korean population. -genetics_GWAS hsa-mir-146a "Squamous Cell Carcinoma, Oral" 22182931 "This study identifies that areca nut extract, TNFalpha and TGFbeta up-regulates miR-146a in OSCC cells. The increased expression of miR-146a enhanced the oncogenicity of OSCC cells. In addition, a G to C polymorphism (rs2910164), which is located in the pre-miR-146a and has been associated with functional alterations in miR-146a, was significantly more prevalent among OSCC patients having more advanced nodal involvement. Our analysis also suggested a higher miR-146a expression in OSCC tissues of patients carrying C polymorphism. The present study concluded a higher prevalence of the pre-mir-146a C-variant was associated with OSCC progression in patients with this disease." -genetics_GWAS hsa-mir-570 Gastric Neoplasms 22190470 A guanine-to-cytosine mutation at the 3'-UTR of CD274 mRNA led to CD274 over-expression by disrupting the miR-570 binding. A frequent somatic mutation in CD274 3'-UTR leads to protein over-expression in gastric cancer by disrupting miR-570 binding. -genetics_GWAS hsa-mir-200b Endometrial Neoplasms 22194984 Luciferase assays and Western blot analysis demonstrated that the miR-200b/200c/429 family recognized the MRE in the 3' UTR of AP-2alpha gene and negatively regulated the expression of endogenous AP-2alpha proteins. SNP rs1045385 A>C variation enhanced AP-2alpha. -genetics_GWAS hsa-mir-200c Endometrial Neoplasms 22194984 Luciferase assays and Western blot analysis demonstrated that the miR-200b/200c/429 family recognized the MRE in the 3' UTR of AP-2 alpha gene and negatively regulated the expression of endogenous AP-2 alpha proteins. SNP rs1045385 A>C variation enhanced AP-2 alpha expression. -genetics_GWAS hsa-mir-429 Endometrial Neoplasms 22194984 Luciferase assays and Western blot analysis demonstrated that the miR-200b/200c/429 family recognized the MRE in the 3' UTR of AP-2 alpha gene and negatively regulated the expression of endogenous AP-2 alpha proteins. SNP rs1045385 A>C variation enhanced AP-2 alpha expression. -genetics_GWAS hsa-mir-146a Systemic Lupus Erythematosus 22218224 "The SNP (rs2431697) was associated with the microRNA-146a, where the risk allele correlates with lower expression of the miRNA." -genetics_GWAS hsa-mir-196a-2 Habitual Abortion 22222140 "RSA(recurrent spontaneous abortion) patients exhibited significantly different frequencies of the miR-196a2CC (TT+TC vs. CC; adjusted odds ratio [AOR], 1.587; 95% confidence interval [CI], 1.042-2.417) and miR-499AG+GG genotypes (AOR, 1.671; 95% CI, 1.054-2.651) compared with the control group." -genetics_GWAS hsa-mir-499a Habitual Abortion 22222140 "RSA(recurrent spontaneous abortion) patients exhibited significantly different frequencies of the miR-196a2CC (TT+TC vs. CC; adjusted odds ratio [AOR], 1.587; 95% confidence interval [CI], 1.042-2.417) and miR-499AG+GG genotypes (AOR, 1.671; 95% CI, 1.054-2.651) compared with the control group." -genetics_GWAS hsa-mir-17 Ovarian Neoplasms 22235027 "The most notable cluster is the tumorigenic miR-17-92 cluster with five microRNAs, all of which are significantly associated with rs3814113" -genetics_GWAS hsa-mir-18a Ovarian Neoplasms 22235027 "The most notable cluster is the tumorigenic miR-17-92 cluster with five microRNAs, all of which are significantly associated with rs3814113" -genetics_GWAS hsa-mir-19a Ovarian Neoplasms 22235027 "The most notable cluster is the tumorigenic miR-17-92 cluster with five microRNAs, all of which are significantly associated with rs3814113" -genetics_GWAS hsa-mir-19b-1 Ovarian Neoplasms 22235027 "The most notable cluster is the tumorigenic miR-17-92 cluster with five microRNAs, all of which are significantly associated with rs3814113" -genetics_GWAS hsa-mir-20a Ovarian Neoplasms 22235027 "The most notable cluster is the tumorigenic miR-17-92 cluster with five microRNAs, all of which are significantly associated with rs3814113" -genetics_GWAS hsa-mir-92a-1 Ovarian Neoplasms 22235027 "The most notable cluster is the tumorigenic miR-17-92 cluster with five microRNAs, all of which are significantly associated with rs3814113" -genetics_GWAS hsa-let-7e Crohn Disease 22262659 The rs10889677 variant in the 3'-untranslated region of the IL-23R gene displays enhanced levels of both mRNA and protein production of IL-23R. This can be attributed to a loss of binding capacity for the microRNAs (miRNAs) Let-7e and Let-7f by the variant allele. -genetics_GWAS hsa-let-7f-1 Crohn Disease 22262659 The rs10889677 variant in the 3'-untranslated region of the IL-23R gene displays enhanced levels of both mRNA and protein production of IL-23R. This can be attributed to a loss of binding capacity for the microRNAs (miRNAs) Let-7e and Let-7f by the variant allele. -genetics_GWAS hsa-let-7f-2 Crohn Disease 22262659 The rs10889677 variant in the 3'-untranslated region of the IL-23R gene displays enhanced levels of both mRNA and protein production of IL-23R. This can be attributed to a loss of binding capacity for the microRNAs (miRNAs) Let-7e and Let-7f by the variant allele. -genetics_GWAS hsa-let-7a-1 Endometriosis 22307873 The authors detected a KRAS variant allele in 31% of women with endometriosis as opposed to 5% of a large diverse control population. -genetics_GWAS hsa-let-7a-2 Endometriosis 22307873 The authors detected a KRAS variant allele in 31% of women with endometriosis as opposed to 5% of a large diverse control population. -genetics_GWAS hsa-let-7a-3 Endometriosis 22307873 The authors detected a KRAS variant allele in 31% of women with endometriosis as opposed to 5% of a large diverse control population. -genetics_GWAS hsa-let-7b Endometriosis 22307873 The authors detected a KRAS variant allele in 31% of women with endometriosis as opposed to 5% of a large diverse control population. -genetics_GWAS hsa-let-7c Endometriosis 22307873 The authors detected a KRAS variant allele in 31% of women with endometriosis as opposed to 5% of a large diverse control population. -genetics_GWAS hsa-let-7d Endometriosis 22307873 The authors detected a KRAS variant allele in 31% of women with endometriosis as opposed to 5% of a large diverse control population. -genetics_GWAS hsa-let-7e Endometriosis 22307873 The authors detected a KRAS variant allele in 31% of women with endometriosis as opposed to 5% of a large diverse control population. -genetics_GWAS hsa-let-7f-1 Endometriosis 22307873 The authors detected a KRAS variant allele in 31% of women with endometriosis as opposed to 5% of a large diverse control population. -genetics_GWAS hsa-let-7f-2 Endometriosis 22307873 The authors detected a KRAS variant allele in 31% of women with endometriosis as opposed to 5% of a large diverse control population. -genetics_GWAS hsa-let-7g Endometriosis 22307873 The authors detected a KRAS variant allele in 31% of women with endometriosis as opposed to 5% of a large diverse control population. -genetics_GWAS hsa-let-7i Endometriosis 22307873 The authors detected a KRAS variant allele in 31% of women with endometriosis as opposed to 5% of a large diverse control population. -genetics_GWAS hsa-mir-1207 Glomerulonephritis 22319602 "A miR-1207-5p binding site polymorphism (C1936T, rs13385) abolishes regulation of HBEGF and is associated with disease severity in CFHR5 nephropathy." -genetics_GWAS hsa-mir-155 "Lymphoma, Non-Hodgkin" 22347493 "Variant rs928883, near miR-155, showed an association (OR per A-allele: 2.80 [95% CI: 1.63-4.82]; p(F)=0.027) with marginal zone lymphoma that is significant after correction for multiple testing." -genetics_GWAS hsa-mir-1273c Colorectal Carcinoma 22348132 "hsa-mir-1273c, hsa-mir-1303 and hsa-mir-567, with frequent and sometimes bi-allelic mutations in MSI tumors." -genetics_GWAS hsa-mir-1303 Colorectal Carcinoma 22348132 "hsa-mir-1273c, hsa-mir-1303 and hsa-mir-567, with frequent and sometimes bi-allelic mutations in MSI tumors." -genetics_GWAS hsa-mir-567 Colorectal Carcinoma 22348132 "hsa-mir-1273c, hsa-mir-1303 and hsa-mir-567, with frequent and sometimes bi-allelic mutations in MSI tumors." -genetics_GWAS hsa-mir-25 Lung Neoplasms 22349819 REV3L 3'UTR 460 T>C polymorphism in microRNA(miR-25/32) target sites contributes to lung cancer susceptibility. -genetics_GWAS hsa-mir-32 Lung Neoplasms 22349819 REV3L 3'UTR 460 T>C polymorphism in microRNA(miR-25/32) target sites contributes to lung cancer susceptibility. -genetics_GWAS hsa-mir-27a Gastric Neoplasms 22350505 The SNP rs895819 in the miR-27a gene with the minor allele C presented significantly reduced risk to gastric cancer in Chinese population. -genetics_GWAS hsa-mir-146a Breast Neoplasms 22363415 "The authors found that hs-miR-196a2 in premenopausal patients, and hs-miR-499, hs-miR-146a and hs-miR-196a2 in postmenopausal patients, may discriminate breast cancer patients from healthy individuals. In addition, we found a significant association between two microRNA polymorphisms (hs-miR-196a2 and hs-miR-499) and breast cancer risk." -genetics_GWAS hsa-mir-196a-2 Breast Neoplasms 22363415 "The authors found that hs-miR-196a2 in premenopausal patients, and hs-miR-499, hs-miR-146a and hs-miR-196a2 in postmenopausal patients, may discriminate breast cancer patients from healthy individuals. In addition, we found a significant association between two microRNA polymorphisms (hs-miR-196a2 and hs-miR-499) and breast cancer risk." -genetics_GWAS hsa-mir-499a Breast Neoplasms 22363415 "The authors found that hs-miR-196a2 in premenopausal patients, and hs-miR-499, hs-miR-146a and hs-miR-196a2 in postmenopausal patients, may discriminate breast cancer patients from healthy individuals. In addition, we found a significant association between two microRNA polymorphisms (hs-miR-196a2 and hs-miR-499) and breast cancer risk." -genetics_GWAS hsa-mir-146a Breast Neoplasms 22363684 Increased Risk of Breast Cancer Associated with CC Genotype of Has-miR-146a Rs2910164 Polymorphism in Europeans. -genetics_GWAS hsa-mir-499a Heart Failure 22374132 A naturally occurring miR-499 mutation(u17c in the 3' end) outside the critical seed sequence modifies mRNA targeting and end-organ function. -genetics_GWAS hsa-mir-106b "Carcinoma, Hepatocellular" 22393390 "A Genetic Variant (rs999885) in the Promoter Region of miR-106b-25 Cluster and Risk of HBV Infection and Hepatocellular Carcinoma.Compared with the HBV natural clearance subjects carrying rs999885 AA genotype, those with AG/GG genotypes had a decreased risk of chronic HBV infection with an adjusted odds ratio (OR) of 0.79 [95% confidence intervals (CIs)=0.67-0.93]. However, the AG/GG genotypes were significantly associated with an increased HCC risk in HBV persistent carriers (adjusted OR=1.25, 95% CIs=1.06-1.47). Expression analysis revealed that the expression level of miR-106b-25 cluster was significantly higher in AG/GG carriers than those in AA carriers in non-tumor liver tissues." -genetics_GWAS hsa-mir-106b Hepatitis B Virus Infection 22393390 "A Genetic Variant (rs999885) in the Promoter Region of miR-106b-25 Cluster and Risk of HBV Infection and Hepatocellular Carcinoma.Compared with the HBV natural clearance subjects carrying rs999885 AA genotype, those with AG/GG genotypes had a decreased risk of chronic HBV infection with an adjusted odds ratio (OR) of 0.79 [95% confidence intervals (CIs)=0.67-0.93]. However, the AG/GG genotypes were significantly associated with an increased HCC risk in HBV persistent carriers (adjusted OR=1.25, 95% CIs=1.06-1.47). Expression analysis revealed that the expression level of miR-106b-25 cluster was significantly higher in AG/GG carriers than those in AA carriers in non-tumor liver tissues." -genetics_GWAS hsa-mir-25 "Carcinoma, Hepatocellular" 22393390 "A Genetic Variant (rs999885) in the Promoter Region of miR-106b-25 Cluster and Risk of HBV Infection and Hepatocellular Carcinoma.Compared with the HBV natural clearance subjects carrying rs999885 AA genotype, those with AG/GG genotypes had a decreased risk of chronic HBV infection with an adjusted odds ratio (OR) of 0.79 [95% confidence intervals (CIs)=0.67-0.93]. However, the AG/GG genotypes were significantly associated with an increased HCC risk in HBV persistent carriers (adjusted OR=1.25, 95% CIs=1.06-1.47). Expression analysis revealed that the expression level of miR-106b-25 cluster was significantly higher in AG/GG carriers than those in AA carriers in non-tumor liver tissues." -genetics_GWAS hsa-mir-25 Hepatitis B Virus Infection 22393390 "A Genetic Variant (rs999885) in the Promoter Region of miR-106b-25 Cluster and Risk of HBV Infection and Hepatocellular Carcinoma.Compared with the HBV natural clearance subjects carrying rs999885 AA genotype, those with AG/GG genotypes had a decreased risk of chronic HBV infection with an adjusted odds ratio (OR) of 0.79 [95% confidence intervals (CIs)=0.67-0.93]. However, the AG/GG genotypes were significantly associated with an increased HCC risk in HBV persistent carriers (adjusted OR=1.25, 95% CIs=1.06-1.47). Expression analysis revealed that the expression level of miR-106b-25 cluster was significantly higher in AG/GG carriers than those in AA carriers in non-tumor liver tissues." -genetics_GWAS hsa-mir-325 Dyspepsia 22438098 "Genetic polymorphism ( rs5981521 (C>T)) of pri-microRNA 325, targeting SLC6A4 3'-UTR, is closely associated with the risk of functional dyspepsia in Japan." -genetics_GWAS hsa-mir-146a Gastric Neoplasms 22455393 A Functional Polymorphism (rs2910164) in Pre-miR-146a Is Associated with Susceptibility to Gastric Cancer in a Chinese Population. -genetics_GWAS hsa-mir-938 Gastric Neoplasms 22537748 "Genetic polymorphisms of IL17A ((rs2275913 (-197 G > A), rs3748067 (*1249 C > T)) and pri-microRNA-938 (pri-miR-938, rs2505901 (T > C).), targeting IL17A 3'-UTR, influence susceptibility to gastric cancer." -genetics_GWAS hsa-mir-520a Colorectal Carcinoma 22553375 A 3' untranslated region (UTR) mutation was also shown to be associated with increased sensitivity to saracatinib and have a reduced affinity for miR-520a and miR-525a. -genetics_GWAS hsa-mir-608 Breast Neoplasms 22586447 Polymorphism rs4919510:C>G in mature sequence of human microRNA-608 contributes to the risk of HER2-positive breast cancer but not other subtypes. -genetics_GWAS hsa-mir-423 Breast Neoplasms 22593246 A genetic variant (rs6505162:A>C) located in miR-423 is associated with reduced breast cancer risk. -genetics_GWAS hsa-mir-608 Colorectal Carcinoma 22606253 rs4919510 in hsa-mir-608 is associated with outcome but not risk of colorectal cancer. -genetics_GWAS hsa-mir-146a Moyamoya Disease 22659075 "Association of the miR-146aC>G, miR-196a2C>T, and miR-499A>G polymorphisms with moyamoya disease in the Korean population." -genetics_GWAS hsa-mir-196a-2 Moyamoya Disease 22659075 "Association of the miR-146aC>G, miR-196a2C>T, and miR-499A>G polymorphisms with moyamoya disease in the Korean population." -genetics_GWAS hsa-mir-219-1 Colorectal Carcinoma 22661538 "The mir219-1:rs213210 showed consistent association with death in the training set, the replication set, and combined data set" -genetics_GWAS hsa-mir-608 Colorectal Carcinoma 22661538 "In patients with stage III disease, mir608: rs4919510 was associated with increased risk for both recurrence and death." -genetics_GWAS hsa-mir-146a Nasopharyngeal Neoplasms 22711332 A single nucleotide polymorphism (rs2910164) in microRNA-146a is associated with the risk for nasopharyngeal carcinoma. -genetics_GWAS hsa-mir-182 Melanoma 22752337 Up-regulation of miR-182 expression after epigenetic modulation of human melanoma cells. -genetics_GWAS hsa-mir-499a "Squamous Cell Carcinoma, Oral" 22761899 "This study determined that a significant association of miRNA499 with CC genotype, as compared to the subjects with TT genotype, had a higher risk of oral squamous cell carcinoma." -genetics_GWAS hsa-mir-499b "Squamous Cell Carcinoma, Oral" 22761899 "This study determined that a significant association of miRNA499 with CC genotype, as compared to the subjects with TT genotype, had a higher risk of oral squamous cell carcinoma." -genetics_GWAS hsa-mir-7-1 Urinary Bladder Cancer 22768238 A microRNA-7 binding site polymorphism (1010A/G) in HOXB5 leads to differential gene expression in bladder cancer. -genetics_GWAS hsa-mir-7-2 Urinary Bladder Cancer 22768238 A microRNA-7 binding site polymorphism (1010A/G) in HOXB5 leads to differential gene expression in bladder cancer. -genetics_GWAS hsa-mir-7-3 Urinary Bladder Cancer 22768238 A microRNA-7 binding site polymorphism (1010A/G) in HOXB5 leads to differential gene expression in bladder cancer. -genetics_GWAS hsa-mir-146a Lung Neoplasms 22818121 Our findings suggest that polymorphisms in the rs2910164 of miR-146a and the rs11614913 of miR-196a2 are associated with prognosis in patients with completely resected NSCLC. -genetics_GWAS hsa-mir-196a Lung Neoplasms 22818121 Our findings suggest that polymorphisms in the rs2910164 of miR-146a and the rs11614913 of miR-196a2 are associated with prognosis in patients with completely resected NSCLC. -genetics_GWAS hsa-mir-146a Asthma 22823586 MiR-146a polymorphism is associated with asthma but not with systemic lupus erythematosus and juvenile rheumatoid arthritis in Mexican patients. -genetics_GWAS hsa-mir-1231 "Carcinoma, Hepatocellular" 22824466 A miR-1231 binding site polymorphism (rs17875871) in the 3'UTR of IFNAR1 is associated with hepatocellular carcinoma susceptibility. -genetics_GWAS hsa-mir-125b-1 "Leukemia, Myeloid, Acute" 22843432 MicroRNA-125b-1 accelerates a C-terminal mutant of C/EBP¦Á (C/EBP¦Á-C(m))-induced myeloid leukemia. -genetics_GWAS hsa-mir-34b Intracranial Aneurysm 22844323 "The CC genotype of miR-34b/c rs4938723 was significantly associated with a decreased risk of IA compared with the TT genotype. Moreover, a significant gene interaction of the carriers with the combined genotypes of miR-34b/c rs4938723CC and TP53 Arg72Pro CG/CC/GG had a decreased risk of IA, compared with those carrying miR-34b/c rs4938723CT/TT+TP53 Arg72Pro GG/CG/CC combined genotypes." -genetics_GWAS hsa-mir-34c Intracranial Aneurysm 22844323 "The CC genotype of miR-34b/c rs4938723 was significantly associated with a decreased risk of IA compared with the TT genotype. Moreover, a significant gene interaction of the carriers with the combined genotypes of miR-34b/c rs4938723CC and TP53 Arg72Pro CG/CC/GG had a decreased risk of IA, compared with those carrying miR-34b/c rs4938723CT/TT+TP53 Arg72Pro GG/CG/CC combined genotypes." -genetics_GWAS hsa-mir-146a Urinary Bladder Cancer 22846912 miR-146a rs2910164 C allele inhibited cell proliferation and significantly downregulates expression of IRAK1 and TRAF6 in bladder cancer cells. -genetics_GWAS hsa-mir-196a-1 Esophageal Neoplasms 22859270 MiR-196a binding-site SNP (rs6573) regulates RAP1A expression contributing to esophageal squamous cell carcinoma risk and metastasis. -genetics_GWAS hsa-mir-196a-2 Esophageal Neoplasms 22859270 MiR-196a binding-site SNP (rs6573) regulates RAP1A expression contributing to esophageal squamous cell carcinoma risk and metastasis. -genetics_GWAS hsa-mir-502 Ovarian Neoplasms 22867998 A polymorphism (rs16917496) at the miR-502 binding site in the 3' untranslated region of the SET8 gene is associated with the risk of epithelial ovarian cancer. -genetics_GWAS hsa-let-7a-2 Ovarian Neoplasms 22970210 "We found that there was a reduction in the copy number of let-7 genes in a cancer-type specific manner. Importantly, focal deletion of four let-7 family members was found in three cancer types: medulloblastoma (let-7a-2 and let-7e), breast cancer (let-7a-2), and ovarian cancer (let-7a-3/let-7b)." -genetics_GWAS hsa-let-7e Ovarian Neoplasms 22970210 "We found that there was a reduction in the copy number of let-7 genes in a cancer-type specific manner. Importantly, focal deletion of four let-7 family members was found in three cancer types: medulloblastoma (let-7a-2 and let-7e), breast cancer (let-7a-2), and ovarian cancer (let-7a-3/let-7b)." -genetics_GWAS hsa-mir-499 Breast Neoplasms 23053947 "In conclusion, this meta-analysis suggests that the miR-499 rs3746444 polymorphism (A>G) is a low-penetrant risk factor for cancer development among Asians and may contribute to breast cancer susceptibility." -genetics_GWAS hsa-mir-337 "Leukemia, Myeloid, Acute" 23065518 A polymorphism in the 3'-untranslated region of the NPM1 gene causes illegitimate regulation by microRNA-337-5p and correlates with adverse outcome in acute myeloid leukemia -genetics_GWAS hsa-mir-200c Gastric Neoplasms 23065816 G-A variant in miR-200c binding site of EFNA1 alters susceptibility to gastric cancer -genetics_GWAS hsa-mir-370 "Leukemia, Myeloid, Acute" 23077663 Integration of SNP and mRNA arrays with microRNA profiling reveals that MiR-370 is upregulated and targets NF1 in acute myeloid leukemia -genetics_GWAS hsa-mir-27a "Carcinoma, Renal Cell" 23118855 A genetic variant in pre-miR-27a is associated with a reduced renal cell cancer risk in a Chinese population -genetics_GWAS hsa-mir-196a-1 Lung Neoplasms 23143626 Hsa-miR-196a2 functional SNP is associated with severe toxicity after platinum-based chemotherapy of advanced nonsmall cell lung cancer patients in a Chinese population -genetics_GWAS hsa-mir-196a-2 Lung Neoplasms 23143626 Hsa-miR-196a2 functional SNP is associated with severe toxicity after platinum-based chemotherapy of advanced nonsmall cell lung cancer patients in a Chinese population -genetics_GWAS hsa-mir-30c-1 Lung Neoplasms 23159078 Single nucleotide polymorphism in flanking region of miR-30c influences the maturing process of miR-30c in lung carcinoma -genetics_GWAS hsa-mir-30c-2 Lung Neoplasms 23159078 Single nucleotide polymorphism in flanking region of miR-30c influences the maturing process of miR-30c in lung carcinoma -genetics_GWAS hsa-mir-146a Acute Cerebral Infarction 23202363 "Association of the miR-146a, miR-149, miR-196a2, and miR-499 Polymorphisms With Ischemic Stroke and Silent Brain Infarction Risk" -genetics_GWAS hsa-mir-149 Acute Cerebral Infarction 23202363 "Association of the miR-146a, miR-149, miR-196a2, and miR-499 Polymorphisms With Ischemic Stroke and Silent Brain Infarction Risk" -genetics_GWAS hsa-mir-196a-1 Acute Cerebral Infarction 23202363 "Association of the miR-146a, miR-149, miR-196a2, and miR-499 Polymorphisms With Ischemic Stroke and Silent Brain Infarction Risk" -genetics_GWAS hsa-mir-196a-2 Acute Cerebral Infarction 23202363 "Association of the miR-146a, miR-149, miR-196a2, and miR-499 Polymorphisms With Ischemic Stroke and Silent Brain Infarction Risk" -genetics_GWAS hsa-mir-146a Melanoma 23222547 The rs2910164 G>C polymorphism in microRNA-146a is associated with the incidence of malignant melanoma -genetics_GWAS hsa-mir-196a-1 Breast Neoplasms 23228090 Evaluation of single nucleotide polymorphisms in microRNAs (hsa-miR-196a2 rs11614913 C/T) from Brazilian women with breast cancer -genetics_GWAS hsa-mir-196a-2 Breast Neoplasms 23228090 Evaluation of single nucleotide polymorphisms in microRNAs (hsa-miR-196a2 rs11614913 C/T) from Brazilian women with breast cancer -genetics_GWAS hsa-mir-27a Gastric Neoplasms 23246964 Genetic variations in miR-27a gene decrease mature miR-27a level and reduce gastric cancer susceptibility -genetics_GWAS hsa-mir-146a Behcet Disease 23268366 MicroRNA-146a and Ets-1 gene polymorphisms in ocular Behcet's disease and Vogt-Koyanagi-Harada syndrome -genetics_GWAS hsa-mir-885 Head And Neck Neoplasms 23271051 A functional variant at the miR-885-5p binding site of CASP3 confers risk of both index and second primary malignancies in patients with head and neck cancer -genetics_GWAS hsa-mir-149 "Squamous Cell Carcinoma, Head and Neck" 23272122 The Association between Genetic Polymorphism and the Processing Efficiency of miR-149 Affects the Prognosis of Patients with Head and Neck Squamous Cell Carcinoma -genetics_GWAS hsa-mir-146a Hepatitis B Virus Infection 23292505 Association of a single-nucleotide polymorphism within the miR-146a gene with susceptibility for acute-on-chronic hepatitis B liver failure -genetics_GWAS hsa-mir-146a Colorectal Carcinoma 23306950 A genetic variant in miR-146a modifies colorectal cancer susceptibility in a chinese population -genetics_GWAS hsa-mir-218-1 Urinary Bladder Cancer 23320911 The pri-miR-218 rs11134527 SNP was significantly associated with the risk of cervical carcinoma in Eastern Chinese women -genetics_GWAS hsa-mir-218-2 Urinary Bladder Cancer 23320911 The pri-miR-218 rs11134527 SNP was significantly associated with the risk of cervical carcinoma in Eastern Chinese women -genetics_GWAS hsa-mir-520a Endometriosis 23364396 A microRNA-520 mirSNP at the MMP2 gene influences susceptibility to endometriosis in Chinese women -genetics_GWAS hsa-mir-520b Endometriosis 23364396 A microRNA-520 mirSNP at the MMP2 gene influences susceptibility to endometriosis in Chinese women -genetics_GWAS hsa-mir-520c Endometriosis 23364396 A microRNA-520 mirSNP at the MMP2 gene influences susceptibility to endometriosis in Chinese women -genetics_GWAS hsa-mir-520d Endometriosis 23364396 A microRNA-520 mirSNP at the MMP2 gene influences susceptibility to endometriosis in Chinese women -genetics_GWAS hsa-mir-520e Endometriosis 23364396 A microRNA-520 mirSNP at the MMP2 gene influences susceptibility to endometriosis in Chinese women -genetics_GWAS hsa-mir-520f Endometriosis 23364396 A microRNA-520 mirSNP at the MMP2 gene influences susceptibility to endometriosis in Chinese women -genetics_GWAS hsa-mir-520g Endometriosis 23364396 A microRNA-520 mirSNP at the MMP2 gene influences susceptibility to endometriosis in Chinese women -genetics_GWAS hsa-mir-520h Endometriosis 23364396 A microRNA-520 mirSNP at the MMP2 gene influences susceptibility to endometriosis in Chinese women -genetics_GWAS hsa-mir-22 Heart Failure 23372812 Common variation neighbouring micro-RNA 22 is associated with increased left ventricular mass. -genetics_GWAS hsa-mir-367 Colorectal Carcinoma 23393343 the functional variant (rs1044129) in the miR-367 binding site of RYR3 may be a potential marker for prognosis in patients following curative surgery for CRC -genetics_GWAS hsa-mir-151a Nasopharyngeal Neoplasms 23416081 A miR-151 binding site polymorphism in the 3'-untranslated region of the cyclin E1 gene associated with nasopharyngeal carcinoma -genetics_GWAS hsa-mir-151b Nasopharyngeal Neoplasms 23416081 A miR-151 binding site polymorphism in the 3'-untranslated region of the cyclin E1 gene associated with nasopharyngeal carcinoma -genetics_GWAS hsa-mir-125a Breast Neoplasms 23420759 rs12976445 variant in the pri-miR-125a correlates with a lower level of hsa-miR-125a and ERBB2 overexpression in breast cancer patients -genetics_GWAS hsa-mir-196a-2 Vitiligo 23433405 A Single Nucleotide Polymorphism of miR-196a-2 and Vitiligo: An Association Study and Functional Analysis in a Han Chinese Population -genetics_GWAS hsa-mir-146a Thyroid Neoplasms 23451063 Association between the rs2910164 Polymorphism in Pre-Mir-146a Sequence and Thyroid Carcinogenesis -genetics_GWAS hsa-mir-34b Nasopharyngeal Neoplasms 23504554 Interactions of miR-34b/c and TP-53 polymorphisms on the risk of nasopharyngeal carcinoma -genetics_GWAS hsa-mir-34c Nasopharyngeal Neoplasms 23504554 Interactions of miR-34b/c and TP-53 polymorphisms on the risk of nasopharyngeal carcinoma -genetics_GWAS hsa-mir-196a-1 Hepatitis B Virus Infection 23516510 Associations of pri-miR-34b/c and pre-miR-196a2 Polymorphisms and Their Multiplicative Interactions with Hepatitis B Virus Mutations with Hepatocellular Carcinoma Risk -genetics_GWAS hsa-mir-196a-2 Hepatitis B Virus Infection 23516510 Associations of pri-miR-34b/c and pre-miR-196a2 Polymorphisms and Their Multiplicative Interactions with Hepatitis B Virus Mutations with Hepatocellular Carcinoma Risk -genetics_GWAS hsa-mir-34b Hepatitis B Virus Infection 23516510 Associations of pri-miR-34b/c and pre-miR-196a2 Polymorphisms and Their Multiplicative Interactions with Hepatitis B Virus Mutations with Hepatocellular Carcinoma Risk -genetics_GWAS hsa-mir-34c Hepatitis B Virus Infection 23516510 Associations of pri-miR-34b/c and pre-miR-196a2 Polymorphisms and Their Multiplicative Interactions with Hepatitis B Virus Mutations with Hepatocellular Carcinoma Risk -genetics_GWAS hsa-mir-196a Neoplasms [unspecific] 23691458 "The meta-analysis demonstrated that the miR-196a-2 polymorphism is associated with cancer susceptibility, especially lung cancer, colorectal cancer, and breast cancer among Asian populations." -genetics_GWAS hsa-mir-184 Gastric Neoplasms 23724109 The miR-184 Binding-Site rs8126 T>C Polymorphism in TNFAIP2 Is Associated with Risk of Gastric Cancer. -genetics_GWAS hsa-mir-137 Psychiatric Disorders 23786914 Analysis of miR-137 expression and rs1625579 in dorsolateral prefrontal cortex. -genetics_GWAS hsa-mir-196a-2 "Carcinoma, Hepatocellular" 23791656 Three common functional polymorphisms in microRNA encoding genes in the susceptibility to hepatocellular carcinoma: a systematic review and meta-analysis. -genetics_GWAS hsa-mir-499 "Carcinoma, Hepatocellular" 23791656 Three common functional polymorphisms in microRNA encoding genes in the susceptibility to hepatocellular carcinoma: a systematic review and meta-analysis. -genetics_GWAS hsa-mir-146a "Squamous Cell Carcinoma, Esophageal" 23792053 "These findings indicated that functional polymorphism miR-196a2 rs11614913 T > C might contribute to decreased ESCC risk among women patients and patients who never smoking or drinking. However, our results were obtained with a limited sample size. Future larger studies with other ethnic populations and tissue-specific biological characterization are required to confirm current findings." -genetics_GWAS hsa-mir-196a-2 "Squamous Cell Carcinoma, Esophageal" 23792053 "These findings indicated that functional polymorphism miR-196a2 rs11614913 T > C might contribute to decreased ESCC risk among women patients and patients who never smoking or drinking. However, our results were obtained with a limited sample size. Future larger studies with other ethnic populations and tissue-specific biological characterization are required to confirm current findings." -genetics_GWAS hsa-mir-26a-1 "Squamous Cell Carcinoma, Esophageal" 23792053 "These findings indicated that functional polymorphism miR-196a2 rs11614913 T > C might contribute to decreased ESCC risk among women patients and patients who never smoking or drinking. However, our results were obtained with a limited sample size. Future larger studies with other ethnic populations and tissue-specific biological characterization are required to confirm current findings." -genetics_GWAS hsa-mir-27a "Squamous Cell Carcinoma, Esophageal" 23792053 "These findings indicated that functional polymorphism miR-196a2 rs11614913 T > C might contribute to decreased ESCC risk among women patients and patients who never smoking or drinking. However, our results were obtained with a limited sample size. Future larger studies with other ethnic populations and tissue-specific biological characterization are required to confirm current findings." -genetics_GWAS hsa-mir-499 "Squamous Cell Carcinoma, Esophageal" 23792053 "These findings indicated that functional polymorphism miR-196a2 rs11614913 T > C might contribute to decreased ESCC risk among women patients and patients who never smoking or drinking. However, our results were obtained with a limited sample size. Future larger studies with other ethnic populations and tissue-specific biological characterization are required to confirm current findings." -genetics_GWAS hsa-mir-146a Coronary Artery Disease 23794009 "miR-146a polymorphism influences levels of miR-146a, IRAK-1, and TRAF-6 in young patients with coronary artery disease." -genetics_GWAS hsa-mir-608 "Carcinoma, Nasopharyngeal" 23796562 A sequence polymorphism in miR-608 predicts recurrence after radiotherapy for nasopharyngeal carcinoma. -genetics_GWAS hsa-mir-124 Hepatitis B Virus Infection 23807362 Association between microRNA polymorphisms and humoral immunity to hepatitis B vaccine. -genetics_GWAS hsa-mir-146a Hepatitis B Virus Infection 23807362 Association between microRNA polymorphisms and humoral immunity to hepatitis B vaccine. -genetics_GWAS hsa-mir-149 Hepatitis B Virus Infection 23807362 Association between microRNA polymorphisms and humoral immunity to hepatitis B vaccine. -genetics_GWAS hsa-mir-196a-2 Hepatitis B Virus Infection 23807362 Association between microRNA polymorphisms and humoral immunity to hepatitis B vaccine. -genetics_GWAS hsa-mir-26a-1 Hepatitis B Virus Infection 23807362 Association between microRNA polymorphisms and humoral immunity to hepatitis B vaccine. -genetics_GWAS hsa-mir-27a Hepatitis B Virus Infection 23807362 Association between microRNA polymorphisms and humoral immunity to hepatitis B vaccine. -genetics_GWAS hsa-mir-146 Colorectal Carcinoma 23898084 "The current study provides evidence that the miR-146a rs2690164 polymorphism, as the dominant model of the G allele, is associated with the susceptibility and prognosis of CRC." -genetics_GWAS hsa-mir-182 Hyperactivity Disorder 23906647 Evaluation of single nucleotide polymorphisms in the miR-183-96-182 cluster in adulthood attention-deficit and hyperactivity disorder (ADHD) and substance use disorders (SUDs). -genetics_GWAS hsa-mir-183 Hyperactivity Disorder 23906647 Evaluation of single nucleotide polymorphisms in the miR-183-96-182 cluster in adulthood attention-deficit and hyperactivity disorder (ADHD) and substance use disorders (SUDs). -genetics_GWAS hsa-mir-96 Hyperactivity Disorder 23906647 Evaluation of single nucleotide polymorphisms in the miR-183-96-182 cluster in adulthood attention-deficit and hyperactivity disorder (ADHD) and substance use disorders (SUDs). -genetics_GWAS hsa-mir-34b "Carcinoma, Hepatocellular" 23935875 Lack of association of MiR-34b/c polymorphism (rs4938723) with hepatocellular carcinoma: a meta-analysis. -genetics_GWAS hsa-mir-31 Hypertension 23943853 Human angiotensinogen +11525 C/A polymorphism modulates its gene expression through microRNA binding. -genetics_GWAS hsa-mir-584 Hypertension 23943853 Human angiotensinogen +11525 C/A polymorphism modulates its gene expression through microRNA binding. -genetics_GWAS hsa-mir-27a Breast Neoplasms 23954879 A genetic variant in pre-miR-27a is associated with a reduced breast cancer risk in younger Chinese population. -genetics_GWAS hsa-mir-146a Gastric Neoplasms 23975664 Prognostic role of microRNA polymorphisms in advanced gastric cancer: a translational study of the Arbeitsgemeinschaft Internistische Onkologie (AIO). -genetics_GWAS hsa-mir-196a-2 Gastric Neoplasms 23975664 Prognostic role of microRNA polymorphisms in advanced gastric cancer: a translational study of the Arbeitsgemeinschaft Internistische Onkologie (AIO). -genetics_GWAS hsa-mir-219-1 Gastric Neoplasms 23975664 Prognostic role of microRNA polymorphisms in advanced gastric cancer: a translational study of the Arbeitsgemeinschaft Internistische Onkologie (AIO). -genetics_GWAS hsa-mir-26a-1 Gastric Neoplasms 23975664 Prognostic role of microRNA polymorphisms in advanced gastric cancer: a translational study of the Arbeitsgemeinschaft Internistische Onkologie (AIO). -genetics_GWAS hsa-mir-27a Gastric Neoplasms 23975664 Prognostic role of microRNA polymorphisms in advanced gastric cancer: a translational study of the Arbeitsgemeinschaft Internistische Onkologie (AIO). -genetics_GWAS hsa-mir-423 Gastric Neoplasms 23975664 Prognostic role of microRNA polymorphisms in advanced gastric cancer: a translational study of the Arbeitsgemeinschaft Internistische Onkologie (AIO). -genetics_GWAS hsa-mir-196a-2 Breast Neoplasms 23982873 "the current meta-analysis supports that the miR-196a-2 rs11614913*T, miR-499 rs3746444*T, miR-605 rs2043556*A, and miR-27a rs895919*C alleles might be protective factors for breast cancer" -genetics_GWAS hsa-mir-27a Breast Neoplasms 23982873 "the current meta-analysis supports that the miR-196a-2 rs11614913*T, miR-499 rs3746444*T, miR-605 rs2043556*A, and miR-27a rs895919*C alleles might be protective factors for breast cancer" -genetics_GWAS hsa-mir-499 Breast Neoplasms 23982873 "the current meta-analysis supports that the miR-196a-2 rs11614913*T, miR-499 rs3746444*T, miR-605 rs2043556*A, and miR-27a rs895919*C alleles might be protective factors for breast cancer" -genetics_GWAS hsa-mir-605 Breast Neoplasms 23982873 "the current meta-analysis supports that the miR-196a-2 rs11614913*T, miR-499 rs3746444*T, miR-605 rs2043556*A, and miR-27a rs895919*C alleles might be protective factors for breast cancer" -genetics_GWAS hsa-mir-146a Breast Neoplasms 24039706 "This meta-analysis demonstrates the compelling evidence that the rs11614913 CC genotype in miR-196a2 increases breast cancer risk, which provides useful information for the early diagnosis and prevention of breast cancer." -genetics_GWAS hsa-mir-196a Breast Neoplasms 24039706 "This meta-analysis demonstrates the compelling evidence that the rs11614913 CC genotype in miR-196a2 increases breast cancer risk, which provides useful information for the early diagnosis and prevention of breast cancer." -genetics_GWAS hsa-mir-499 Breast Neoplasms 24039706 "This meta-analysis demonstrates the compelling evidence that the rs11614913 CC genotype in miR-196a2 increases breast cancer risk, which provides useful information for the early diagnosis and prevention of breast cancer." -genetics_GWAS hsa-mir-149 "Carcinoma, Hepatocellular" 24040059 Results of this meta-analysis suggest that the hsa-miR-149 rs2292832 polymorphism is not associated with cancer risk in spite of the potentially protective role of C allele in hepatocellular carcinoma and male gastric cancer. -genetics_GWAS hsa-mir-21 Bladder Neoplasms 24078506 "In accordance to the observed similarity between TGF-¦Â variants and miR-21 gene expression alterations in bladder tumors, treating 5637 bladder cancer cell line with TGF-¦Â recombinant protein caused a significant upregulation of miR-21. The later finding further confirmed a correlated expression of TGF-¦Âand miR-21 in bladder tumors." -genetics_GWAS hsa-mir-499 Neoplasms [unspecific] 24085457 The miR-499 rs3746444 polymorphism is associated with an increased cancer risk. -genetics_GWAS hsa-mir-499 Gastric Neoplasms 24107911 The rs3746444 (A>G) SNP is not associated with susceptibility to GC in the Chinese population. -genetics_GWAS hsa-mir-218 "Carcinoma, Hepatocellular" 24118778 "rs11134527 may be a novel genetic risk factor of HCC in HBV-exposed subjects, can facilitate HBV preS deletion generation and predispose the host to the effect of T1674C/G and preS1 start codon mutation in hepatocarcinogenesis." -genetics_GWAS hsa-mir-137 Schizophrenia 24132022 Impact of the genome-wide schizophrenia risk single nucleotide polymorphism (rs1625579) in miR-137 on brain structures in healthy individuals. -genetics_GWAS hsa-mir-146a Colorectal Carcinoma 24136745 Association between microRNA genetic variants and susceptibility to colorectal cancer in Chinese population. -genetics_GWAS hsa-mir-184 Cataract 24138095 "C.57 C > T Mutation in MIR 184 is Responsible for Congenital Cataracts and Corneal Abnormalities in a Five-generation Family from Galicia, Spain." -genetics_GWAS hsa-mir-146a Lung Neoplasms 24144839 "These findings suggest that the rs2910164C>G in pre-miR-146a may contribute to genetic susceptibility to lung cancer, and that miR-146a might be involved in lung cancer development." -genetics_GWAS hsa-mir-502 "Carcinoma, Lung, Non-Small-Cell" 24146953 Our data suggested that the rs16917496 T>C located at miR-502 binding site contributes to NSCLC survival by altering SET8 expression through modulating miRNA-target interaction. -genetics_GWAS hsa-mir-561 "Carcinoma, Breast" 24166930 Genetic variant rs16430 6bp > 0bp at the microRNA-binding site in TYMS and risk of sporadic breast cancer risk in non-Hispanic white women aged ¡Ü 55 years. -genetics_GWAS hsa-mir-423 "Squamous Cell Carcinoma, Esophageal" 24205249 MicroRNA polymorphisms and environmental smoke exposure as risk factors for oesophageal squamous cell carcinoma. -genetics_GWAS hsa-mir-27a "Carcinoma, Lung, Non-Small-Cell" 24223174 Our results suggest that the pre-miR-27a rs895819 polymorphism may influence NSCLC patients' clinical outcome. Further large sample studies should be used to validate our findings. -genetics_GWAS hsa-mir-146a "Carcinoma, Lung" 24246082 The rs2910164 C allele in pre-miR-146a and rs11614913 C allele in pre-miR-196a2 were associated with increased genetic damage levels in coke oven workers -genetics_GWAS hsa-mir-196a-2 "Carcinoma, Lung" 24246082 The rs2910164 C allele in pre-miR-146a and rs11614913 C allele in pre-miR-196a2 were associated with increased genetic damage levels in coke oven workers -genetics_GWAS hsa-mir-146a Digestive System Neoplasms 24247819 miR-146a gene polymorphism rs2910164 and the risk of digestive tumors: A meta-analysis of 21 case-control studies. -genetics_GWAS hsa-mir-196a-2 Chronic Hepatitis B 24248733 MicroRNA-196A-2 polymorphisms and hepatocellular carcinoma in patients with chronic hepatitis B. -genetics_GWAS hsa-mir-499 Neoplasms [unspecific] 24258110 Quantitative assessment of the association between microRNA-499 rs3746444 A/G polymorphism and cancer risk. -genetics_GWAS hsa-mir-34b "Carcinoma, Esophageal" 24260422 Hsa-miR-34b/c rs4938723 T>C and hsa-miR-423 rs6505162 C>A polymorphisms are associated with the risk of esophageal cancer in a Chinese population. -genetics_GWAS hsa-mir-34c "Carcinoma, Esophageal" 24260422 Hsa-miR-34b/c rs4938723 T>C and hsa-miR-423 rs6505162 C>A polymorphisms are associated with the risk of esophageal cancer in a Chinese population. -genetics_GWAS hsa-mir-423 "Carcinoma, Esophageal" 24260422 Hsa-miR-34b/c rs4938723 T>C and hsa-miR-423 rs6505162 C>A polymorphisms are associated with the risk of esophageal cancer in a Chinese population. -genetics_GWAS hsa-mir-146a Neoplasms [unspecific] 24278149 Association between microRNA polymorphisms and cancer risk based on the findings of 66 case-control studies. -genetics_GWAS hsa-mir-149 Neoplasms [unspecific] 24278149 Association between microRNA polymorphisms and cancer risk based on the findings of 66 case-control studies. -genetics_GWAS hsa-mir-196a-2 Neoplasms [unspecific] 24278149 Association between microRNA polymorphisms and cancer risk based on the findings of 66 case-control studies. -genetics_GWAS hsa-mir-499 Neoplasms [unspecific] 24278149 Association between microRNA polymorphisms and cancer risk based on the findings of 66 case-control studies. -genetics_GWAS hsa-mir-100 "Squamous Cell Carcinoma, Esophageal" 24288122 "Taken together, these findings indicate that miRNA polymorphisms may predict prognosis in advanced ESCC patients receiving platinum-based chemotherapy." -genetics_GWAS hsa-mir-125a "Squamous Cell Carcinoma, Esophageal" 24288122 "Taken together, these findings indicate that miRNA polymorphisms may predict prognosis in advanced ESCC patients receiving platinum-based chemotherapy." -genetics_GWAS hsa-mir-146a "Squamous Cell Carcinoma, Esophageal" 24288122 "Taken together, these findings indicate that miRNA polymorphisms may predict prognosis in advanced ESCC patients receiving platinum-based chemotherapy." -genetics_GWAS hsa-mir-196a-2 "Squamous Cell Carcinoma, Esophageal" 24288122 "Taken together, these findings indicate that miRNA polymorphisms may predict prognosis in advanced ESCC patients receiving platinum-based chemotherapy." -genetics_GWAS hsa-mir-26a-1 "Squamous Cell Carcinoma, Esophageal" 24288122 "Taken together, these findings indicate that miRNA polymorphisms may predict prognosis in advanced ESCC patients receiving platinum-based chemotherapy." -genetics_GWAS hsa-mir-34b Oral Neoplasms 24297336 Genetic variations at microRNA and processing genes and risk of oral cancer. -genetics_GWAS hsa-mir-499 "Carcinoma, Hepatocellular" 24301908 miR-499A>G rs3746444 and miR-146aG>C expression and hepatocellular carcinoma risk in the Chinese population. -genetics_GWAS hsa-mir-27b Bladder Neoplasms 24312312 "Taken together, these findings suggested that DROSHA rs10719T>C polymorphism may be associated with bladder cancer risk in a Chinese population, and hsa-miR-27b can influence the expression of DROSHA protein by binding with 3'UTR." -genetics_GWAS hsa-mir-196a-2 "Squamous Cell Carcinoma, Esophageal" 24320161 These results suggest that the miRNA-196a2 functional polymorphism rs11614913 might be an effective genetic marker for ESCC risk assessment in individuals younger than 60 years of age from a region of high ESCC incidence in northern China. -genetics_GWAS hsa-mir-499 Rheumatoid Arthritis 24327058 This study suggested that miR-499 polymorphisms were associated with a significantly increased risk of RA in Mediterranean populations. -genetics_GWAS hsa-mir-21 "Squamous Cell Carcinoma, Head and Neck" 24327270 "CLU is a specific, functional target of oncogenic miRNA-21 in HNSCCs. CLU-1 isoform is the predominant growth-suppressive variant targeted by miRNA-21." -genetics_GWAS hsa-mir-34b Colorectal Carcinoma 24337371 Polymorphisms of the pri-miR-34b/c promoter and TP53 codon 72 are associated with risk of colorectal cancer. -genetics_GWAS hsa-mir-34c Colorectal Carcinoma 24337371 Polymorphisms of the pri-miR-34b/c promoter and TP53 codon 72 are associated with risk of colorectal cancer. -genetics_GWAS hsa-mir-125b Endometriosis 24339876 Genetic variation at the miR-125b binding site may play functional roles to protect against endometriosis progression. -genetics_GWAS hsa-mir-502 "Carcinoma, Lung, Non-Small-Cell" 24374662 Association of miR-502-binding site single nucleotide polymorphism in the 3'-untranslated region of SET8 and TP53 codon 72 polymorphism with non-small cell lung cancer in Chinese population. -genetics_GWAS hsa-mir-146a "Carcinoma, Hepatocellular" 24377574 "Our results demonstrate that miR-196a4 CC genotype and C allele have an important role in HCC risk in Chinese, especially in patients with HBV infection." -genetics_GWAS hsa-mir-196a "Carcinoma, Hepatocellular" 24377574 "Our results demonstrate that miR-196a2 CC genotype and C allele have an important role in HCC risk in Chinese, especially in patients with HBV infection." -genetics_GWAS hsa-mir-499 "Carcinoma, Hepatocellular" 24377574 "Our results demonstrate that miR-196a3 CC genotype and C allele have an important role in HCC risk in Chinese, especially in patients with HBV infection." -genetics_GWAS hsa-mir-146a Gastric Neoplasms 24379078 "Association of the miR-146aC>G, miR-149T>C, and miR-196a2T>C polymorphisms with gastric cancer risk and survival in the Greek population." -genetics_GWAS hsa-mir-149 Gastric Neoplasms 24379078 "Association of the miR-146aC>G, miR-149T>C, and miR-196a2T>C polymorphisms with gastric cancer risk and survival in the Greek population." -genetics_GWAS hsa-mir-196a-2 Gastric Neoplasms 24379078 "Association of the miR-146aC>G, miR-149T>C, and miR-196a2T>C polymorphisms with gastric cancer risk and survival in the Greek population." -genetics_GWAS hsa-mir-27a "Carcinoma, Cervical" 24380734 A genetic variant in pre-miR-27a is associated with a reduced cervical cancer risk in southern Chinese women. -genetics_GWAS hsa-mir-485 Hyperglycemia 24387992 An APOA5 3' UTR variant associated with plasma triglycerides triggers APOA5 downregulation by creating a functional miR-485-5p binding site. -genetics_GWAS hsa-mir-146a Colorectal Carcinoma 24399071 Effects of common polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on susceptibility to colorectal cancer: a systematic review meta-analysis. -genetics_GWAS hsa-mir-196a-2 Colorectal Carcinoma 24399071 Effects of common polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on susceptibility to colorectal cancer: a systematic review meta-analysis. -genetics_GWAS hsa-mir-106b "Carcinoma, Hepatocellular" 24416400 A genetic variant in the promoter region of miR-106b-25 cluster predict clinical outcome of HBV-related hepatocellular carcinoma in Chinese. -genetics_GWAS hsa-mir-330 Psychiatric Disorders 24436253 The effects of a MAP2K5 microRNA target site SNP on risk for anxiety and depressive disorders. -genetics_GWAS hsa-mir-146 Coronary Artery Disease 24447667 A common variant in pre-miR-146 is associated with coronary artery disease risk and its mature miRNA expression. -genetics_GWAS hsa-mir-135b "Carcinoma, Cervical" 24465869 Genetic variants in microRNA target sites of 37 selected cancer-related genes and the risk of cervical cancer. -genetics_GWAS hsa-mir-101-1 Breast Neoplasms 24475105 Genetic variations in the flanking regions of miR-101-2 are associated with increased risk of breast cancer. -genetics_GWAS hsa-mir-101-2 Breast Neoplasms 24475105 Genetic variations in the flanking regions of miR-101-2 are associated with increased risk of breast cancer. -genetics_GWAS hsa-mir-146a Immune Thrombocytopenic Purpura 24502829 hsa-mir-146a rs2910164 polymorphism and risk of immune thrombocytopenia. -genetics_GWAS hsa-mir-34b "Carcinoma, Renal Cell" 24503183 A potentially functional polymorphism in the promoter region of miR-34b/c is associated with renal cell cancer risk in a Chinese population. -genetics_GWAS hsa-mir-34c "Carcinoma, Renal Cell" 24503183 A potentially functional polymorphism in the promoter region of miR-34b/c is associated with renal cell cancer risk in a Chinese population. -genetics_GWAS hsa-mir-499 Breast Neoplasms 24521023 Our findings demonstrated that the hsa-mir-499 rs3746444 polymorphism is associated with higher risk of developing breast cancer in our population. -genetics_GWAS hsa-mir-146a Gastric Neoplasms 24528016 A genetic variant in MiR-146a modifies digestive system cancer risk: a meta-analysis. -genetics_GWAS hsa-mir-146a Colorectal Carcinoma 24568449 These findings supported that the miR-196a2 rs11614913 and miR-149 rs2292832 polymorphisms may contribute to susceptibility to CRC. -genetics_GWAS hsa-mir-149 Colorectal Carcinoma 24568449 These findings supported that the miR-196a2 rs11614913 and miR-149 rs2292832 polymorphisms may contribute to susceptibility to CRC. -genetics_GWAS hsa-mir-196a Colorectal Carcinoma 24568449 These findings supported that the miR-196a2 rs11614913 and miR-149 rs2292832 polymorphisms may contribute to susceptibility to CRC. -genetics_GWAS hsa-mir-499 Colorectal Carcinoma 24568449 These findings supported that the miR-196a2 rs11614913 and miR-149 rs2292832 polymorphisms may contribute to susceptibility to CRC. -genetics_GWAS hsa-mir-624 Gastric Neoplasms 24568522 Bioinformatic prediction of SNPs within miRNA binding sites of inflammatory genes associated with gastric cancer. -genetics_GWAS hsa-mir-146a Alzheimer Disease 24586483 A functional polymorphism in the promoter region of microRNA-146a is associated with the risk of Alzheimer disease and the rate of cognitive decline in patients. -genetics_GWAS hsa-mir-146a "Carcinoma, Hepatocellular" 24587132 "These results suggest that a significant association exists between miRNA499 SNPs and hepatocellular carcinoma. Gene-environment interactions of miRNA499 polymorphisms, smoking, and alcohol consumption might alter hepatocellular carcinoma susceptibility." -genetics_GWAS hsa-mir-149 "Carcinoma, Hepatocellular" 24587132 "These results suggest that a significant association exists between miRNA499 SNPs and hepatocellular carcinoma. Gene-environment interactions of miRNA499 polymorphisms, smoking, and alcohol consumption might alter hepatocellular carcinoma susceptibility." -genetics_GWAS hsa-mir-196 "Carcinoma, Hepatocellular" 24587132 "These results suggest that a significant association exists between miRNA499 SNPs and hepatocellular carcinoma. Gene-environment interactions of miRNA499 polymorphisms, smoking, and alcohol consumption might alter hepatocellular carcinoma susceptibility." -genetics_GWAS hsa-mir-499 "Carcinoma, Hepatocellular" 24587132 "These results suggest that a significant association exists between miRNA499 SNPs and hepatocellular carcinoma. Gene-environment interactions of miRNA499 polymorphisms, smoking, and alcohol consumption might alter hepatocellular carcinoma susceptibility." -genetics_GWAS hsa-mir-124 "Carcinoma, Cervical" 24589598 "miR-124 rs531564 polymorphism may play a role in cervical cancer susceptibility in Chinese Han women, and G allele is associated with a reduced risk of cervical cancer." -genetics_GWAS hsa-mir-526b "Carcinoma, Gastric" 24595048 The has-miR-526b binding-site rs8506G>a polymorphism in the lincRNA-NR_024015 exon identified by GWASs predispose to non-cardia gastric cancer risk. -genetics_GWAS hsa-mir-3649 Non-Syndromic Orofacial Clefts 24603642 "Taken together, these findings indicate that SNPs in the miRNA-binding sites might play an important role in the development of NSOCs. Furthermore, if confirmed in subsequent studies, the polymorphisms may be considered as additional markers for the evaluation of infants' risk of NSOCs." -genetics_GWAS hsa-mir-146a "Carcinoma, Hepatocellular" 24615520 miR-146a G>C polymorphisms and risk of hepatocellular carcinoma in a Chinese population. -genetics_GWAS hsa-mir-499 "Leukemia, Lymphoblastic, Acute" 24618566 "We found 11 SNPs significantly associated with ALL susceptibility. These included three SNPs present in miRNA genes (miR-612, miR-499, and miR-449b) and eight SNPs present in six miRNA biogenesis pathway genes (TNRC6B, DROSHA, DGCR8, EIF2C1, CNOT1, and CNOT6)." -genetics_GWAS hsa-mir-146a Alcohol Use Disorder 24630744 This is the first genetic association study to explore the relationship of miRNA polymorphisms with AUDs and to show an association of the miR-146a C>G rs2910164 allelic variant with this disease. -genetics_GWAS hsa-mir-196a-2 Liver Neoplasms 24633889 "Quantitative assessment of the association between miR-196a2 rs11614913 polymorphism and cancer risk: evidence based on 45,816 subjects." -genetics_GWAS hsa-mir-2278 Multiple Sclerosis 24638856 Assessment of microRNA-related SNP effects in the 3' untranslated region of the IL22RA2 risk locus in multiple sclerosis. -genetics_GWAS hsa-mir-411 Multiple Sclerosis 24638856 Assessment of microRNA-related SNP effects in the 3' untranslated region of the IL22RA2 risk locus in multiple sclerosis. -genetics_GWAS hsa-mir-146a Uveitis 24658012 This study shows that miR-146a and Ets-1 are both associated with pediatric uveitis in Han Chinese. SNP rs10893872 may affect the genetic predisposition to pediatric uveitis by modulating expression of Ets-1. -genetics_GWAS hsa-mir-4436b-1 Autism Spectrum Disorder 24667286 Assessing the impact of copy number variants on miRNA genes in autism by Monte Carlo simulation. -genetics_GWAS hsa-mir-4436b-2 Autism Spectrum Disorder 24667286 Assessing the impact of copy number variants on miRNA genes in autism by Monte Carlo simulation. -genetics_GWAS hsa-mir-424 Myelodysplastic Syndromes 24674452 Detection of an activated JAK3 variant and a Xq26.3 microdeletion causing loss of PHF6 and miR-424 expression in myelodysplastic syndromes by combined targeted next generation sequencing and SNP array analysis. -genetics_GWAS hsa-mir-224 Coronary Artery Disease 24676100 Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation. -genetics_GWAS hsa-mir-149 "Carcinoma, Renal Cell" 24681820 "We genotyped four common miRNA SNPs (i.e. miR-146a rs2910164, miR-149 rs2292832, miR-196a2 rs11614913 and miR-499 rs3746444) to assess their associations with RCC risk in a two-stage case-control study (355 cases and 362 controls in discovery set, meanwhile 647 cases and 660 controls in validation set), as well as RCC survival in 311 patients." -genetics_GWAS hsa-mir-518 Hypertension 24687999 Our results suggest that TGFBR2 and miR-518 harbor variants that increase the risk of EH and affect blood pressure homeostasis as well as efficacy of antihypertensive agents. -genetics_GWAS hsa-mir-146a Skin Neoplasms 24699816 "we investigated the impact of MIR146A SNP rs2910164 on cancer risk, and interaction with a SNP in one of its putative targets (RNASEL, rs486907)." -genetics_GWAS hsa-mir-146a Sepsis 24701036 The functional polymorphisms of miR-146a are associated with susceptibility to severe sepsis in the Chinese population. -genetics_GWAS hsa-mir-146a Dermatomyositis 24716199 MIRSNP rs2910164 of miR-146a is associated with the muscle involvement in polymyositis/dermatomyositis. -genetics_GWAS hsa-mir-146a Neoplasms [unspecific] 24716941 Association analysis of single nucleotide polymorphisms in miR-146a and miR-196a2 on the prevalence of cancer in elderly Japanese: a case-control study. -genetics_GWAS hsa-mir-196a-2 Neoplasms [unspecific] 24716941 Association analysis of single nucleotide polymorphisms in miR-146a and miR-196a2 on the prevalence of cancer in elderly Japanese: a case-control study. -genetics_GWAS hsa-mir-142 "Leukemia, Myeloid, Acute" 24724784 Absence of miR-142 mutation in Chinese patients with acute myeloid leukemia. -genetics_GWAS hsa-let-7 "Carcinoma, Colon" 24727325 "In the largest association study investigating the LCS6 polymorphism in colon cancers, the germline LCS6 genotype was not associated with KRAS mutation status or with clinical outcome in patients with stage III tumors." -genetics_GWAS hsa-let-7 Hepatitis B Virus Infection 24729511 Association of a functional RAD52 genetic variant locating in a miRNA binding site with risk of HBV-related hepatocellular carcinoma. -genetics_GWAS hsa-mir-146a Colorectal Carcinoma 24740563 Association of a genetic variant in microRNA-146a with risk of colorectal cancer: a population-based case-control study. -genetics_GWAS hsa-mir-378 "Carcinoma, Hepatocellular" 24751683 These findings indicate that rs1076064 may be a biomarker for HCC susceptibility and prognosis through altering pri-miR-378 transcription. -genetics_GWAS hsa-mir-143 Congenital Heart Diseases 24752771 No association of pri-miR-143 rs41291957 polymorphism with the risk of congenital heart disease in a Chinese population. -genetics_GWAS hsa-let-7a Gastric Neoplasms 24760009 "pri-let-7a-2 rs629367 CC genotype could increase the risks of gastric cancer as well as atrophic gastritis and was also associated with poor survival of gastric cancer, which possibly by affecting the mature let-7a expression, and could serve as a predicting biomarker for high-risk and poor prognosis of gastric cancer." -genetics_GWAS hsa-mir-218 Neoplasms [unspecific] 24761857 "The findings suggest that pre-miR-218 rs11134527 polymorphism may have some relation to cancer development in Chinese. However, well-designed studies with larger sample size and more detailed data are needed to confirm these conclusions." -genetics_GWAS hsa-mir-608 "Squamous Cell Carcinoma, Esophageal" 24770678 "The hereditary genetic polymorphisms of mir-608, RAN, and GEMIN4 can serve as predictors for clinical outcome in ESCC patients treated with concurrent chemoradiotherapy." -genetics_GWAS hsa-mir-146a IgA Nephropathy 24781267 These results indicated that rs2910164 may affect the susceptibility and severity of pediatric IgAN. Further studies are needed to validate these findings. -genetics_GWAS hsa-mir-182 Behcet Disease 24801147 Predisposition to Behcet's disease and VKH syndrome by genetic variants of miR-182. -genetics_GWAS hsa-mir-146a Systemic Lupus Erythematosus 24803388 Association of miR-146a polymorphisms with systemic lupus erythematosus: a meta-analysis. -genetics_GWAS hsa-mir-26b Obesity 24807789 "Expression of microRNA-26b, an obesity-related microRNA, is regulated by free fatty acids, glucose, dexamethasone and growth hormone in human adipocytes." -genetics_GWAS hsa-mir-146a "Carcinoma, Hepatocellular" 24816919 Association between miR-146aG>C and miR-196a2C>T polymorphisms and the risk of hepatocellular carcinoma in a Chinese population. -genetics_GWAS hsa-mir-196a-2 "Carcinoma, Hepatocellular" 24816919 Association between miR-146aG>C and miR-196a2C>T polymorphisms and the risk of hepatocellular carcinoma in a Chinese population. -genetics_GWAS hsa-mir-499 "Carcinoma, Hepatocellular" 24816919 Association between miR-146aG>C and miR-196a2C>T polymorphisms and the risk of hepatocellular carcinoma in a Chinese population. -genetics_GWAS hsa-mir-146a Rheumatoid Arthritis 24824381 Association of two polymorphisms rs2910164 in miRNA-146a and rs3746444 in miRNA-499 with rheumatoid arthritis: a meta-analysis. -genetics_GWAS hsa-mir-499 Rheumatoid Arthritis 24824381 Association of two polymorphisms rs2910164 in miRNA-146a and rs3746444 in miRNA-499 with rheumatoid arthritis: a meta-analysis. -genetics_GWAS hsa-mir-33b Hyperglycemia 24825092 Association of rs8066560 variant in the sterol regulatory element-binding protein 1 (SREBP-1) and miR-33b genes with hyperglycemia and insulin resistance. -genetics_GWAS hsa-mir-146a Myocardial Infarction 24850191 Association of microRNA polymorphisms with the risk of myocardial infarction in a Chinese population. -genetics_GWAS hsa-mir-149 Myocardial Infarction 24850191 Association of microRNA polymorphisms with the risk of myocardial infarction in a Chinese population. -genetics_GWAS hsa-mir-196a-2 Myocardial Infarction 24850191 Association of microRNA polymorphisms with the risk of myocardial infarction in a Chinese population. -genetics_GWAS hsa-mir-218 Myocardial Infarction 24850191 Association of microRNA polymorphisms with the risk of myocardial infarction in a Chinese population. -genetics_GWAS hsa-mir-499 Myocardial Infarction 24850191 Association of microRNA polymorphisms with the risk of myocardial infarction in a Chinese population. -genetics_GWAS hsa-mir-196a-2 "Carcinoma, Lung, Non-Small-Cell" 24853117 "Importantly, this method can be further applied to analyze the point mutation of mir-196a2 in the lung tissues of non small-cell lung cancer patients." -genetics_GWAS hsa-mir-499 "Carcinoma, Hepatocellular" 24854593 "miR-499 rs3746444 may contribute to the risk and prognosis of HCC, indicating that this SNP could be developed as a biomarker for HCC prediction." -genetics_GWAS hsa-mir-29a Oral Neoplasms 24885463 Variations in microRNAs and their processing genes modulated risk of precancer but further in-depth study is needed to understand mechanism of disease process. -genetics_GWAS hsa-mir-34b Oral Neoplasms 24885463 Variations in microRNAs and their processing genes modulated risk of precancer but further in-depth study is needed to understand mechanism of disease process. -genetics_GWAS hsa-mir-423 Oral Neoplasms 24885463 Variations in microRNAs and their processing genes modulated risk of precancer but further in-depth study is needed to understand mechanism of disease process. -genetics_GWAS hsa-mir-34c "Leukemia, Myeloid" 24886876 Our study implicates that microRNA-binding site polymorphisms modulate leukemia risk by interfering with the miRNA-mediated regulation. Our findings underscore the significance of variability in 3' untranslated regions in leukemia. -genetics_GWAS hsa-mir-449b "Leukemia, Myeloid" 24886876 Our study implicates that microRNA-binding site polymorphisms modulate leukemia risk by interfering with the miRNA-mediated regulation. Our findings underscore the significance of variability in 3' untranslated regions in leukemia. -genetics_GWAS hsa-let-7 Colorectal Carcinoma 24890702 Let-7 microRNA-binding-site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta-analysis. -genetics_GWAS hsa-mir-196a Breast Neoplasms 24922658 The current study provides evidence that the miR-196a rs11614913T>C polymorphisms are possible prognostic biomarker for patients with hormone receptor-expressing early breast cancer. -genetics_GWAS hsa-mir-603 Colorectal Carcinoma 24934365 "Our data suggest that hsa-miR-603 may be involved in colorectal tumorigenesis, and the genetic polymorphism in hsa-miR-603 is associated with CRC susceptibility." -genetics_GWAS hsa-mir-124 "Squamous Cell Carcinoma, Esophageal" 24945256 Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in Chinese populations. -genetics_GWAS hsa-mir-34b "Squamous Cell Carcinoma, Esophageal" 24945256 Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in Chinese populations. -genetics_GWAS hsa-mir-34c "Squamous Cell Carcinoma, Esophageal" 24945256 Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in Chinese populations. -genetics_GWAS hsa-mir-146a "Stroke, Ischemic" 24952884 miR-146a and miR-196a2 polymorphisms in patients with ischemic stroke in the northern Chinese Han population. -genetics_GWAS hsa-mir-196a-2 "Stroke, Ischemic" 24952884 miR-146a and miR-196a2 polymorphisms in patients with ischemic stroke in the northern Chinese Han population. -genetics_GWAS hsa-mir-196a-2 "Diabetes Mellitus, Type 2" 24972764 Our findings suggest that miRNA-196a2 T/C polymorphism (rs11614913) is associated with an increased risk of CVD in type 2 diabetes patients. This provides further insights on pathogenesis of cardiovascular disease in type 2 diabetes patients. -genetics_GWAS hsa-mir-132 Gastric Neoplasms 24981235 "A functional variant at miR-132-3p, miR-212-3p, and miR-361-5p binding site in CD80 gene alters susceptibility to gastric cancer in a Chinese Han population." -genetics_GWAS hsa-mir-212 Gastric Neoplasms 24981235 "A functional variant at miR-132-3p, miR-212-3p, and miR-361-5p binding site in CD80 gene alters susceptibility to gastric cancer in a Chinese Han population." -genetics_GWAS hsa-mir-361 Gastric Neoplasms 24981235 "A functional variant at miR-132-3p, miR-212-3p, and miR-361-5p binding site in CD80 gene alters susceptibility to gastric cancer in a Chinese Han population." -genetics_GWAS hsa-mir-410 Stroke 24990426 "We report a novel association between a microRNA target site variant and stroke incidence, which is modulated by diet in terms of decreasing triglycerides and possibly stroke risk in rs13702 C allele carriers after a high-unsaturated fat MedDiet intervention." -genetics_GWAS hsa-mir-125a Autoimmune Thyroiditis 24990808 Associations of single nucleotide polymorphisms in precursor-microRNA (miR)-125a and the expression of mature miR-125a with the development and prognosis of autoimmune thyroid diseases. -genetics_GWAS hsa-mir-122 "Carcinoma, Hepatocellular" 24995424 A genetic variant in microRNA-122 regulatory region confers risk for chronic hepatitis B virus infection and hepatocellular carcinoma in Han Chinese. -genetics_GWAS hsa-mir-485 Breast Neoplasms 25003827 miR-485-5p binding site SNP rs8752 in HPGD gene is associated with breast cancer risk. -genetics_GWAS hsa-mir-137 Schizophrenia 25044277 The miR-137 schizophrenia susceptibility variant rs1625579 does not predict variability in brain volume in a sample of schizophrenic patients and healthy individuals. -genetics_GWAS hsa-mir-146a Coronary Restenosis 25053223 we found a negative association for the G/C (P = 0.007) and a positive association for the C/C genotype with the risk of restenosis -genetics_GWAS hsa-mir-149 "Carcinoma, Hepatocellular" 25061729 Association of miR-149C>T and miR-500A>G polymorphisms with the risk of hepatocellular carcinoma in the Chinese population. -genetics_GWAS hsa-mir-499a "Carcinoma, Hepatocellular" 25061729 Association of miR-149C>T and miR-499A>G polymorphisms with the risk of hepatocellular carcinoma in the Chinese population. -genetics_GWAS hsa-mir-26a Neurodegenerative Diseases [unspecific] 25074322 A functional SNP catalog of overlapping miRNA-binding sites in genes implicated in prion disease and other neurodegenerative disorders. -genetics_GWAS hsa-mir-146a Lung Neoplasms 25077922 Effects of four single nucleotide polymorphisms in microRNA-coding genes on lung cancer risk. -genetics_GWAS hsa-mir-149 Lung Neoplasms 25077922 Effects of four single nucleotide polymorphisms in microRNA-coding genes on lung cancer risk. -genetics_GWAS hsa-mir-196a-2 Lung Neoplasms 25077922 Effects of four single nucleotide polymorphisms in microRNA-coding genes on lung cancer risk. -genetics_GWAS hsa-mir-499b Lung Neoplasms 25077922 Effects of four single nucleotide polymorphisms in microRNA-coding genes on lung cancer risk. -genetics_GWAS hsa-mir-27a Colorectal Carcinoma 25078482 Association between miR-27a genetic variants and susceptibility to colorectal cancer. -genetics_GWAS hsa-mir-146a Prostate Neoplasms 25084752 Association between genetic variant in hsa-miR-146a gene and prostate cancer progression -genetics_GWAS hsa-mir-146a Colorectal Carcinoma 25103961 "Lack of association between miR-27a, miR-146a, miR-196a-2, miR-492 and miR-608 gene polymorphisms and colorectal cancer." -genetics_GWAS hsa-mir-196a-2 Colorectal Carcinoma 25103961 "Lack of association between miR-27a, miR-146a, miR-196a-2, miR-492 and miR-608 gene polymorphisms and colorectal cancer." -genetics_GWAS hsa-mir-27a Colorectal Carcinoma 25103961 "Lack of association between miR-27a, miR-146a, miR-196a-2, miR-492 and miR-608 gene polymorphisms and colorectal cancer." -genetics_GWAS hsa-mir-125a Gastric Neoplasms 25109760 "In this study, we found that a germline mutation in the miR-125a coding region is associated with human gastric cancer." -genetics_GWAS hsa-mir-146a Lung Neoplasms 25154761 MicroRNA-146a rs2910164 polymorphism is associated with susceptibility to non-small cell lung cancer in the Chinese population. -genetics_GWAS hsa-mir-502 "Carcinoma, Cervical" 25169478 "These data suggest that there are significant associations between the miR-502-binding site SNP in the 3'-UTR of SET8 and the TP53 codon 72 polymorphism with cervical cancer in Chinese, and there is a gene-gene interaction." -genetics_GWAS hsa-mir-646 "Carcinoma, Hepatocellular" 25177719 Our findings support the view that the miR-646 SNP rs6513497 may contribute to the susceptibility of HCC. -genetics_GWAS hsa-mir-34a "Carcinoma, Hepatocellular" 25179842 A functional variant at miR-34a binding site in toll-like receptor 4 gene alters susceptibility to hepatocellular carcinoma in a Chinese Han population. -genetics_GWAS hsa-mir-146a Leprosy 25187983 Pre-miR-146a (rs2910164 G>C) single nucleotide polymorphism is genetically and functionally associated with leprosy. -genetics_GWAS hsa-mir-34b Neoplasms [unspecific] 25190019 The genetic association between pri-miR-34b/c polymorphism (rs4938723 T>C) and susceptibility to cancers: evidence from published studies. -genetics_GWAS hsa-mir-34c Neoplasms [unspecific] 25190019 The genetic association between pri-miR-34b/c polymorphism (rs4938723 T>C) and susceptibility to cancers: evidence from published studies. -genetics_GWAS hsa-mir-34b Gastric Neoplasms 25190020 Promoter polymorphisms of miR-34b/c are associated with risk of gastric cancer in a Chinese population. -genetics_GWAS hsa-mir-34c Gastric Neoplasms 25190020 Promoter polymorphisms of miR-34b/c are associated with risk of gastric cancer in a Chinese population. -genetics_GWAS hsa-mir-1 Coronary Artery Disease 25197382 Polymorphism in miRNA-1 target site and circulating miRNA-1 phenotype are associated with the decreased risk and prognosis of coronary artery disease. -genetics_GWAS hsa-mir-146a Psoriasis 25209759 A single-nucleotide polymorphism of miR-146a and psoriasis: an association and functional study. -genetics_GWAS hsa-mir-146a Systemic Lupus Erythematosus 25218914 "The present meta-analysis suggests important roles for the mir-499 rs3746444 polymorphism in RA, especially in the Caucasian population and for miR-146a rs57095329 polymorphism in SLE." -genetics_GWAS hsa-mir-149 "Carcinoma, Hepatocellular" 25222224 Role of miR-149C>T polymorphisms on the risk of hepatocellular carcinoma in a Chinese population. -genetics_GWAS hsa-mir-27a Colorectal Carcinoma 25222241 Association between a functional variant in microRNA-27a and susceptibility to colorectal cancer in a Chinese Han population. -genetics_GWAS hsa-mir-137 Schizophrenia 25241074 Lack of association between microRNA-137 SNP rs1625579 and schizophrenia in a replication study of Han Chinese. -genetics_GWAS hsa-mir-4513 Coronary Artery Disease 25256095 "A genetic variant in the seed region of miR-4513 shows pleiotropic effects on lipid and glucose homeostasis, blood pressure, and coronary artery disease." -genetics_GWAS hsa-mir-146a Arthritis 25269878 This meta-analysis suggests that the miR-499 rs374644 and IRAKI rs3027898 polymorphisms are associated with susceptibility to inflammatory arthritis. -genetics_GWAS hsa-mir-499 Arthritis 25269878 This meta-analysis suggests that the miR-499 rs374644 and IRAKI rs3027898 polymorphisms are associated with susceptibility to inflammatory arthritis. -genetics_GWAS hsa-mir-146a Colorectal Carcinoma 25283877 Effect of a common genetic variant microRNA-146a rs2910164 on colorectal cancer: a meta-analysis. -genetics_GWAS hsa-mir-146a Generalized Epilepsy with Febrile Seizures Plus 25319229 Association of genetic polymorphism of pre-microRNA-146a rs2910164 and serum high-mobility group box 1 with febrile seizures in Egyptian children. -genetics_GWAS hsa-mir-146a Gastric Neoplasms 25326754 The present meta-analysis suggests an increased risk between miR-146a rs2910164 GG genotype and gastric cancer susceptibility in Chinese based on published literatures. -genetics_GWAS hsa-mir-218 "Squamous Cell Carcinoma, Esophageal" 25337271 The impact of pri-miR-218 rs11134527 on the risk and prognosis of patients with esophageal squamous cell carcinoma. -genetics_GWAS hsa-mir-502 "Lymphoma, Non-Hodgkin" 25343552 the SNP in the miRNA binding site of the SET8 3'-untranslated region seems to influence survival of NHL. It may have possible prognostic and survival value in the clinic. -genetics_GWAS hsa-mir-143 Prostate Neoplasms 25354797 there is the significant association between the functional promoter variant rs4705342T>C in miR-143 and PCa risk -genetics_GWAS hsa-mir-518 Premature Ovarian Failure 25365407 "Association study of TGFBR2 and miR-518 gene polymorphisms with age at natural menopause, premature ovarian failure, and early menopause among Chinese Hanwomen." -genetics_GWAS hsa-mir-146a "Lymphoma, B-Cell" 25370733 MicroRNA-146a rs2910164 polymorphism and the risk of diffuse large B cell lymphoma in the Chinese Han population. -genetics_GWAS hsa-mir-184 "Squamous Cell Carcinoma, Esophageal" 25383966 Our data demonstrate that functional TNFAIP2 rs8126 genetic variant is a ESCC susceptibility SNP. -genetics_GWAS hsa-mir-146a Gastric Neoplasms 25386093 "The miR-146a rs2910164 polymorphism is associated with increased gastric cancer risk, particularly evident in high quality studies with small sample sized Caucasian populations." -genetics_GWAS hsa-mir-27a Gastric Neoplasms 25399405 rs895819 and rs11671784 inversely affect gastric cancer risk and the influence was closely related to their effects on miR-27a expression. -genetics_GWAS hsa-mir-148a Gastric Neoplasms 25399950 the SCRN1 rs6976789 polymorphism may play an important role in the GC development and progression. -genetics_GWAS hsa-mir-149 Thyroid Neoplasms 25405731 "Rs2292832 was possibly involved in the susceptibility and local progression of PTC in Chinese patients, by altering the expression level of mir-149-5p and its target genes." -genetics_GWAS hsa-mir-604 "Carcinoma, Hepatocellular" 25408584 "The T allele at miR-604 rs2368392 may be a risk allele for the chronicity of HBV infection, but may be a protective allele for the progression to HCC in chronic HBV carriers." -genetics_GWAS hsa-mir-499 Neoplasms [unspecific] 25433484 "hsa-mir-499 rs3746444 T > C polymorphism is associated with the risk of cancer in Asians, mainly in Iranian and Chinese population. However, rs3746444 T > C polymorphism is negatively associated with the risk of esophageal cancer." -genetics_GWAS hsa-mir-137 Schizophrenia 25434007 "rare noncoding risk variants are associated with SZ and BP at MIR137/MIR2682 locus, with risk alleles decreasing MIR137/MIR2682 expression." -genetics_GWAS hsa-mir-2682 Schizophrenia 25434007 "rare noncoding risk variants are associated with SZ and BP at MIR137/MIR2682 locus, with risk alleles decreasing MIR137/MIR2682 expression." -genetics_GWAS hsa-mir-611 Pleural Mesothelioma 25436799 MRP performance as diagnostic biomarker improved by considering the genotype rs1057147. This polymorphism most likely affects a binding site for miR-611. -genetics_GWAS hsa-mir-146a Hirschsprung Disease 25445498 "the polymorphism rs2910164 in pre-miR-146a might alter the production of mature miR-146a and then down-regulate the target gene ROBO1, which plays an important role in pathogenesis of HSCR." -genetics_GWAS hsa-mir-146a Gastric Neoplasms 25455160 "miR-146a rs2910164 polymorphism was associated with the susceptibility to gastric cancer, especially in Asian population." -genetics_GWAS hsa-mir-34b Colorectal Carcinoma 25475831 rs4938723 was a susceptible locus only for hepatocellular cancer and colorectal cancer. -genetics_GWAS hsa-mir-34c Colorectal Carcinoma 25475831 rs4938723 was a susceptible locus only for hepatocellular cancer and colorectal cancer. -genetics_GWAS hsa-mir-196a "Lymphoma, Non-Hodgkin" 25501512 the miR-196a2 polymorphism may increase the risk of NHL by altering the expression of mature miR-196a. -genetics_GWAS hsa-mir-146a Lung Neoplasms 25524943 mir-196a2 SNP influences the susceptibility of lung cancer. Mir-146a and mir-149 SNP do not play a role in lung cancer risk. These findings need more validation by larger studies. -genetics_GWAS hsa-mir-149 Lung Neoplasms 25524943 mir-196a2 SNP influences the susceptibility of lung cancer. Mir-146a and mir-149 SNP do not play a role in lung cancer risk. These findings need more validation by larger studies. -genetics_GWAS hsa-mir-196a-2 Lung Neoplasms 25524943 mir-196a2 SNP influences the susceptibility of lung cancer. Mir-146a and mir-149 SNP do not play a role in lung cancer risk. These findings need more validation by larger studies. -genetics_GWAS hsa-mir-34a Parkinson Disease 25541488 "down-regulation of miR-34b and miR-34c in the brain, as well as an SNP in the 3'-UTR of ¦Á-syn can increase ¦Á-syn expression, possibly contributing to PD pathogenesis." -genetics_GWAS hsa-mir-146a "Carcinoma, Hepatocellular" 25546664 "the miR-146a rs2910164 polymorphism contributes to increased HCC susceptibility, especially in Asian populations. Further large and well-designed studies are required to validate this association." -genetics_GWAS hsa-mir-196a-2 "Carcinoma, Hepatocellular" 25546664 "the miR-146a rs2910165 polymorphism contributes to increased HCC susceptibility, especially in Asian populations. Further large and well-designed studies are required to validate this association." -genetics_GWAS hsa-mir-146a Digestive System Neoplasms 25555557 "digestive tract neoplasms might associate with miR-146a variants, but not miR-196a2 variants" -genetics_GWAS hsa-mir-196a Digestive System Neoplasms 25555557 "digestive tract neoplasms might associate with miR-146a variants, but not miR-196a2 variants" -genetics_GWAS hsa-mir-27a Breast Neoplasms 25556434 an association between pre-miR-27a polymorphism rs895819 and cancer risk in Caucasians. The protective effect of rs895819 [G] allele in younger breast cancer and in the group of unilateral breast cancer patients await further confirmation since the included studies in this meta-analysis were limited. -genetics_GWAS hsa-mir-320b Coronary Artery Disease 25573129 "The common SNP (rs10916581) in the promoter region of pre-miR-320b-2 might have little contribution to the CHD predisposition in Chinese Han population, and it might not affect circulating miR-320b level. Conventional CHD risk factors (BMI, TC/HDL-C, hypertension and diabetes) might have effects on its circulating level." -genetics_GWAS hsa-mir-146a Multiple Sclerosis 25591770 rs2910164 may play a role in MS susceptibility in females. The rs2910164 G>C variation may affect the expression of miR-146a and the release of proinflammatory cytokines. -genetics_GWAS hsa-mir-499 Lung Neoplasms 25614447 "the rs3746444T>C polymorphism in mature miR-499 sequence could contribute to poor prognosis by modulating cancer-related genes' expression and thus involve tumorigenesis and anti-chemotherapy, which may be a useful biomarker to predict lung cancer patients' prognosis." -genetics_GWAS hsa-mir-208b "Cardiomyopathy, Hypertrophic" 25633875 Sequence variants in miRNAs of patients with HCM are not frequent and the contribution of these variants to the development of this disease was not demonstrated. -genetics_GWAS hsa-mir-367 "Cardiomyopathy, Hypertrophic" 25633875 Sequence variants in miRNAs of patients with HCM are not frequent and the contribution of these variants to the development of this disease was not demonstrated. -genetics_GWAS hsa-mir-499 Neoplasms [unspecific] 25640376 hsa-mir-499 rs3746444 A>G polymorphism is not associated with risk of cancer based on current evidence. -genetics_GWAS hsa-mir-146a "Tuberculosis, Pulmonary" 25650003 "Association of the miR-146a, miR-149, miR-196a2 and miR-499 polymorphisms with susceptibility to pulmonary tuberculosis in the Chinese Uygur, Kazak and Southern Han populations." -genetics_GWAS hsa-mir-149 "Tuberculosis, Pulmonary" 25650003 "Association of the miR-146a, miR-149, miR-196a2 and miR-499 polymorphisms with susceptibility to pulmonary tuberculosis in the Chinese Uygur, Kazak and Southern Han populations." -genetics_GWAS hsa-mir-196a-2 "Tuberculosis, Pulmonary" 25650003 "Association of the miR-146a, miR-149, miR-196a2 and miR-499 polymorphisms with susceptibility to pulmonary tuberculosis in the Chinese Uygur, Kazak and Southern Han populations." -genetics_GWAS hsa-mir-499 "Tuberculosis, Pulmonary" 25650003 "Association of the miR-146a, miR-149, miR-196a2 and miR-499 polymorphisms with susceptibility to pulmonary tuberculosis in the Chinese Uygur, Kazak and Southern Han populations." -genetics_GWAS hsa-mir-34b Gastric Neoplasms 25658980 rs4938723 polymorphism is associated with a decreased risk of gastric cancer. -genetics_GWAS hsa-mir-34c Gastric Neoplasms 25658980 rs4938723 polymorphism is associated with a decreased risk of gastric cancer. -genetics_GWAS hsa-mir-29c Gastric Neoplasms 25661340 A miR-29c binding site genetic variant in the 3'-untranslated region of LAMTOR3 gene is associated with gastric cancer risk. -genetics_GWAS hsa-mir-17 Osteosarcoma 25663449 "This study suggests that SNPs in RISC complex genes may be involved in osteosarcoma susceptibility, especially rs11866002 in CNOT1." -genetics_GWAS hsa-mir-18 Osteosarcoma 25663449 "This study suggests that SNPs in RISC complex genes may be involved in osteosarcoma susceptibility, especially rs11866002 in CNOT1." -genetics_GWAS hsa-mir-19a Osteosarcoma 25663449 "This study suggests that SNPs in RISC complex genes may be involved in osteosarcoma susceptibility, especially rs11866002 in CNOT1." -genetics_GWAS hsa-mir-19b-1 Osteosarcoma 25663449 "This study suggests that SNPs in RISC complex genes may be involved in osteosarcoma susceptibility, especially rs11866002 in CNOT1." -genetics_GWAS hsa-mir-20a Osteosarcoma 25663449 "This study suggests that SNPs in RISC complex genes may be involved in osteosarcoma susceptibility, especially rs11866002 in CNOT1." -genetics_GWAS hsa-mir-92-1 Osteosarcoma 25663449 "This study suggests that SNPs in RISC complex genes may be involved in osteosarcoma susceptibility, especially rs11866002 in CNOT1." -genetics_GWAS hsa-mir-124a "Diabetes Mellitus, Type 2" 25673459 "Affection of single-nucleotide polymorphisms in miR-27a, miR-124a, and miR-146a on susceptibility to type 2 diabetes mellitus in Chinese Han people." -genetics_GWAS hsa-mir-146a "Diabetes Mellitus, Type 2" 25673459 "Affection of single-nucleotide polymorphisms in miR-27a, miR-124a, and miR-146a on susceptibility to type 2 diabetes mellitus in Chinese Han people." -genetics_GWAS hsa-mir-27a "Diabetes Mellitus, Type 2" 25673459 "Affection of single-nucleotide polymorphisms in miR-27a, miR-124a, and miR-146a on susceptibility to type 2 diabetes mellitus in Chinese Han people." -genetics_GWAS hsa-mir-155 "Lymphoma, Large B-Cell, Diffuse" 25677902 "the miRs expression in B-NHLs[11q] provides a new suggestion, in addition to pathomorphological and clinical similarities between classical, i.e.,MYC translocation-positive BL, and B-NHLs[11q], to recognize the B-NHLs[11q] subgroup of DLBCL/BL category as a MYC translocation-negative variant of BL in most cases, and points to the potential utility of miR-155/BIC/miR-21/miR-26a for the differential diagnosis of a heterogeneous category of DLBCL/BL." -genetics_GWAS hsa-mir-21 "Lymphoma, Large B-Cell, Diffuse" 25677902 "the miRs expression in B-NHLs[11q] provides a new suggestion, in addition to pathomorphological and clinical similarities between classical, i.e.,MYC translocation-positive BL, and B-NHLs[11q], to recognize the B-NHLs[11q] subgroup of DLBCL/BL category as a MYC translocation-negative variant of BL in most cases, and points to the potential utility of miR-155/BIC/miR-21/miR-26a for the differential diagnosis of a heterogeneous category of DLBCL/BL." -genetics_GWAS hsa-mir-26a "Lymphoma, Large B-Cell, Diffuse" 25677902 "the miRs expression in B-NHLs[11q] provides a new suggestion, in addition to pathomorphological and clinical similarities between classical, i.e.,MYC translocation-positive BL, and B-NHLs[11q], to recognize the B-NHLs[11q] subgroup of DLBCL/BL category as a MYC translocation-negative variant of BL in most cases, and points to the potential utility of miR-155/BIC/miR-21/miR-26a for the differential diagnosis of a heterogeneous category of DLBCL/BL." -genetics_GWAS hsa-mir-17 Breast Neoplasms 25680407 Association of microRNA 17-92 cluster host gene (MIR17HG) polymorphisms with breast cancer. -genetics_GWAS hsa-mir-18 Breast Neoplasms 25680407 Association of microRNA 17-92 cluster host gene (MIR17HG) polymorphisms with breast cancer. -genetics_GWAS hsa-mir-19a Breast Neoplasms 25680407 Association of microRNA 17-92 cluster host gene (MIR17HG) polymorphisms with breast cancer. -genetics_GWAS hsa-mir-19b-1 Breast Neoplasms 25680407 Association of microRNA 17-92 cluster host gene (MIR17HG) polymorphisms with breast cancer. -genetics_GWAS hsa-mir-20a Breast Neoplasms 25680407 Association of microRNA 17-92 cluster host gene (MIR17HG) polymorphisms with breast cancer. -genetics_GWAS hsa-mir-92-1 Breast Neoplasms 25680407 Association of microRNA 17-92 cluster host gene (MIR17HG) polymorphisms with breast cancer. -genetics_GWAS hsa-mir-605 Li-Fraumeni Syndrome 25683625 A functional variant in miR-605 modifies the age of onset in Li-Fraumeni syndrome. -genetics_GWAS hsa-mir-3162 Prostate Neoplasms 25691096 "Findings from this large association study suggest that a focus on miRSNPs, including functional evaluation, can identify candidate risk loci below currently accepted statistical levels of genome-wide significance. Studies of miRNAs and their interactions with SNPs could provide further insights into the mechanisms of prostate cancer risk." -genetics_GWAS hsa-mir-370 Prostate Neoplasms 25691096 "Findings from this large association study suggest that a focus on miRSNPs, including functional evaluation, can identify candidate risk loci below currently accepted statistical levels of genome-wide significance. Studies of miRNAs and their interactions with SNPs could provide further insights into the mechanisms of prostate cancer risk." -genetics_GWAS hsa-mir-146a Gastrointestinal Neoplasms 25693929 "No significant association between miR-146a rs2910164G/C polymorphism and gastrointestinal cancer susceptibility was found in this meta-analysis. But for homozygous model, people with GG genotype may have increased risk of developing colorectal cancer." -genetics_GWAS hsa-mir-17 "Carcinoma, Lung, Non-Small-Cell" 25716425 The rs3660G>C affects KRT81 expression and thus influences survival in early-stage NSCLC. The analysis of the rs3660G>C polymorphism may be useful to identify patients at high risk of a poor disease outcome. -genetics_GWAS hsa-mir-20b "Carcinoma, Lung, Non-Small-Cell" 25716425 The rs3660G>C affects KRT81 expression and thus influences survival in early-stage NSCLC. The analysis of the rs3660G>C polymorphism may be useful to identify patients at high risk of a poor disease outcome. -genetics_GWAS hsa-mir-146a Chronic Obstructive Pulmonary Disease 25767384 "the rs2910164 CC and GC genotype was found to be associated with an improved lung function and milder disease stages, at least partially, mediated by its ability to increase in COX2 expression and PGE2 production." -genetics_GWAS hsa-mir-146b Psychiatric Disorders 25771167 Our findings highlight trans effects of common variants on microRNA-mediated gene expression as an integral part of the genetic architecture of complex disorders and traits. -genetics_GWAS hsa-mir-107 "Adenocarcinoma, Gastric" 25771723 miR-107 is dysregulated in GAC pathogenesis and the SNP rs2296616 may play a role in the process. -genetics_GWAS hsa-mir-1206 "Leukemia, Lymphocytic, Chronic, B-Cell" 25793711 These findings suggest that polymorphisms in genes involved in miRNAs biogenesis pathway as well as in pre-miRNAs contribute to the risk of CLL. Large-scale studies are needed to validate the current findings. -genetics_GWAS hsa-mir-196a-2 "Leukemia, Lymphocytic, Chronic, B-Cell" 25793711 These findings suggest that polymorphisms in genes involved in miRNAs biogenesis pathway as well as in pre-miRNAs contribute to the risk of CLL. Large-scale studies are needed to validate the current findings. -genetics_GWAS hsa-mir-146a Gastric Neoplasms 25795117 miR-27a rs895819 and miR-149 rs2292832 are of potential forewarning ability for gastric cancer risk. -genetics_GWAS hsa-mir-149 Gastric Neoplasms 25795117 miR-27a rs895819 and miR-149 rs2292832 are of potential forewarning ability for gastric cancer risk. -genetics_GWAS hsa-mir-196a-2 Gastric Neoplasms 25795117 miR-27a rs895819 and miR-149 rs2292832 are of potential forewarning ability for gastric cancer risk. -genetics_GWAS hsa-mir-27a Gastric Neoplasms 25795117 miR-27a rs895819 and miR-149 rs2292832 are of potential forewarning ability for gastric cancer risk. -genetics_GWAS hsa-mir-499 Gastric Neoplasms 25795117 miR-27a rs895819 and miR-149 rs2292832 are of potential forewarning ability for gastric cancer risk. -genetics_GWAS hsa-mir-548ac Multiple Sclerosis 25795118 Susceptibility variants in the CD58 gene locus point to a role of microRNA-548ac in the pathogenesis of multiple sclerosis. -genetics_GWAS hsa-mir-5481 Glaucoma 25809640 These data support the role of hsa-miR-548l as a regulator of FOXC1 translation and provide evidence for the c.*734A>T variant as a modifier factor for the activity of coding glaucoma-associated FOXC1 mutations. -genetics_GWAS hsa-mir-320e Cardiometabolic Disorders 25814643 We provide evidence for a model in which polymorphisms in miRNA-binding sites can both positively and negatively affect miRNA-mediated regulation of cardiometabolic genes. -genetics_GWAS hsa-mir-146a Autoimmune Diseases [unspecific] 25830862 MiR-146a rs2910164 G>C polymorphism was associated with the susceptibility of ADs. -genetics_GWAS hsa-mir-520a Colorectal Carcinoma 25834816 A functional variant at miR-520a binding site in PIK3CA alters susceptibility to colorectal cancer in a Chinese Han population. -genetics_GWAS hsa-mir-146a Ankylosing Spondylitis 25836258 Association between ankylosing spondylitis and the miR-146a and miR-499 polymorphisms. -genetics_GWAS hsa-mir-499 Ankylosing Spondylitis 25836258 Association between ankylosing spondylitis and the miR-146a and miR-499 polymorphisms. -genetics_GWAS hsa-mir-124-1 Neuropsychiatric Disorders [unspecific] 25841663 We showed for the first time the association of a functional polymorphism in MIR124-1 and aggressiveness. Known targets of miR-124 (such as BDNF and DRD4 genes) could explain the effect of this miRNA on behavior. A future analysis of additional novel functional polymorphisms in other brain expressed miRNAs could be useful for a deeper understanding of aggression in humans. -genetics_GWAS hsa-mir-608 "Carcinoma, Nasopharyngeal" 25861865 Polymorphism in mature microRNA-608 sequence is associated with an increased risk of nasopharyngeal carcinoma. -genetics_GWAS hsa-mir-146a Cardiovascular Diseases [unspecific] 25865299 Association of miR-146a rs2910164 polymorphism with cardio-cerebrovascular diseases: A systematic review and meta-analysis. -genetics_GWAS hsa-mir-499 "Carcinoma, Hepatocellular" 25867338 "subjects carrying the miR-499 A allele showed a greatly increased risk of HCC in subjects infected with HBV compared with subjects carrying the miR-499 A allele, with an adjusted odds ratio (95% confidence interval) of 1.53 (1.34-2.41). In conclusion, the miR-146aG>C and miR-499A>G polymorphisms do not have a role in the genetic susceptibility to HCC." -genetics_GWAS hsa-mir-146a Epilepsy 25891929 Our data indicate that the rs57095329 polymorphism in the promoter region of miR-146a is involved in the genetic susceptibility to DRE and the seizures frequency. -genetics_GWAS hsa-mir-196a-2 Vitiligo 25896941 miR-196a-2 rs11614913 polymorphism is associated with vitiligo by affecting heterodimeric molecular complexes of Tyr and Tyrp1. -genetics_GWAS hsa-mir-137 Schizophrenia 25921703 "The impact of genome wide supported microRNA-137 (MIR137) risk variants on frontal and striatal white matter integrity, neurocognitive functioning, and negative symptoms in schizophrenia." -genetics_GWAS hsa-mir-122 "Squamous Cell Carcinoma, Cerevial" 25955681 These findings indicate that the IL1A rs3783553 polymorphism may be associated with the etiology of CSCC. -genetics_GWAS hsa-mir-146a Metabolic Syndrome 25958310 The C allele of miRNA-146a rs2910164 showed positive association with increased susceptibility to metabolic syndrome and its phenotypes in the study population. -genetics_GWAS hsa-let-7c Hepatitis B Virus Infection 25966251 "The meta-analysis results indicated that the miR-196a-2*T,miR-122*del, miR-106b-25*A, and miR-let-7c*del alleles/carriers increase the risk of hepatitis B among the Asian population. However, the miR-146a, miR- 499,miR-149, miR-218, and miR-34b/c polymorphisms may not be linked with the risk of hepatitis B. Further investigations are warranted to determine the exact associations between microRNA mutations and hepatitis B susceptibility." -genetics_GWAS hsa-mir-106b Hepatitis B Virus Infection 25966251 "The meta-analysis results indicated that the miR-196a-2*T,miR-122*del, miR-106b-25*A, and miR-let-7c*del alleles/carriers increase the risk of hepatitis B among the Asian population. However, the miR-146a, miR- 499,miR-149, miR-218, and miR-34b/c polymorphisms may not be linked with the risk of hepatitis B. Further investigations are warranted to determine the exact associations between microRNA mutations and hepatitis B susceptibility." -genetics_GWAS hsa-mir-122 Hepatitis B Virus Infection 25966251 "The meta-analysis results indicated that the miR-196a-2*T,miR-122*del, miR-106b-25*A, and miR-let-7c*del alleles/carriers increase the risk of hepatitis B among the Asian population. However, the miR-146a, miR- 499,miR-149, miR-218, and miR-34b/c polymorphisms may not be linked with the risk of hepatitis B. Further investigations are warranted to determine the exact associations between microRNA mutations and hepatitis B susceptibility." -genetics_GWAS hsa-mir-146a Hepatitis B Virus Infection 25966251 "The meta-analysis results indicated that the miR-196a-2*T,miR-122*del, miR-106b-25*A, and miR-let-7c*del alleles/carriers increase the risk of hepatitis B among the Asian population. However, the miR-146a, miR- 499,miR-149, miR-218, and miR-34b/c polymorphisms may not be linked with the risk of hepatitis B. Further investigations are warranted to determine the exact associations between microRNA mutations and hepatitis B susceptibility." -genetics_GWAS hsa-mir-149 Hepatitis B Virus Infection 25966251 "The meta-analysis results indicated that the miR-196a-2*T,miR-122*del, miR-106b-25*A, and miR-let-7c*del alleles/carriers increase the risk of hepatitis B among the Asian population. However, the miR-146a, miR- 499,miR-149, miR-218, and miR-34b/c polymorphisms may not be linked with the risk of hepatitis B. Further investigations are warranted to determine the exact associations between microRNA mutations and hepatitis B susceptibility." -genetics_GWAS hsa-mir-196a-2 Hepatitis B Virus Infection 25966251 "The meta-analysis results indicated that the miR-196a-2*T,miR-122*del, miR-106b-25*A, and miR-let-7c*del alleles/carriers increase the risk of hepatitis B among the Asian population. However, the miR-146a, miR- 499,miR-149, miR-218, and miR-34b/c polymorphisms may not be linked with the risk of hepatitis B. Further investigations are warranted to determine the exact associations between microRNA mutations and hepatitis B susceptibility." -genetics_GWAS hsa-mir-218 Hepatitis B Virus Infection 25966251 "The meta-analysis results indicated that the miR-196a-2*T,miR-122*del, miR-106b-25*A, and miR-let-7c*del alleles/carriers increase the risk of hepatitis B among the Asian population. However, the miR-146a, miR- 499,miR-149, miR-218, and miR-34b/c polymorphisms may not be linked with the risk of hepatitis B. Further investigations are warranted to determine the exact associations between microRNA mutations and hepatitis B susceptibility." -genetics_GWAS hsa-mir-34b Hepatitis B Virus Infection 25966251 "The meta-analysis results indicated that the miR-196a-2*T,miR-122*del, miR-106b-25*A, and miR-let-7c*del alleles/carriers increase the risk of hepatitis B among the Asian population. However, the miR-146a, miR- 499,miR-149, miR-218, and miR-34b/c polymorphisms may not be linked with the risk of hepatitis B. Further investigations are warranted to determine the exact associations between microRNA mutations and hepatitis B susceptibility." -genetics_GWAS hsa-mir-34c Hepatitis B Virus Infection 25966251 "The meta-analysis results indicated that the miR-196a-2*T,miR-122*del, miR-106b-25*A, and miR-let-7c*del alleles/carriers increase the risk of hepatitis B among the Asian population. However, the miR-146a, miR- 499,miR-149, miR-218, and miR-34b/c polymorphisms may not be linked with the risk of hepatitis B. Further investigations are warranted to determine the exact associations between microRNA mutations and hepatitis B susceptibility." -genetics_GWAS hsa-mir-499 Hepatitis B Virus Infection 25966251 "The meta-analysis results indicated that the miR-196a-2*T,miR-122*del, miR-106b-25*A, and miR-let-7c*del alleles/carriers increase the risk of hepatitis B among the Asian population. However, the miR-146a, miR- 499,miR-149, miR-218, and miR-34b/c polymorphisms may not be linked with the risk of hepatitis B. Further investigations are warranted to determine the exact associations between microRNA mutations and hepatitis B susceptibility." -genetics_GWAS hsa-mir-27a Colorectal Carcinoma 25976406 miR-27a rs895819 polymorphism was associated with increased risk of colorectal cancer in Chinese population. -genetics_GWAS hsa-mir-122 Oral Neoplasms 25981582 "These results suggest that IL-1¦Á 3' UTR rs3783553 polymorphism may be functional and influence susceptibility to HPV16-associated OSCC, particularly for SCCOP. Validation of our findings is warranted." -genetics_GWAS hsa-mir-21 "Carcinoma, Cervical" 25987069 E6D25E of the HPV16As variant differed from the E6 prototype in its activities on epigenetic modulation and immune surveillance and this might be a key factor for the important role of this variant in cervical cancer progression. -genetics_GWAS hsa-mir-214 Gastric Neoplasms 25998065 "Our data suggested that rs114673809, which is located at the miR-214 binding site in the 3'-UTR of MTHFR, may play an important role in the development of gastric cancer in a Chinese Han population." -genetics_GWAS hsa-mir-146a Endometrial Neoplasms 26008204 "Association of SNPs in miR-146a, miR-196a2, and miR-499 with the risk of endometrial/ovarian cancer." -genetics_GWAS hsa-mir-196a-2 Endometrial Neoplasms 26008204 "Association of SNPs in miR-146a, miR-196a2, and miR-499 with the risk of endometrial/ovarian cancer." -genetics_GWAS hsa-mir-499 Endometrial Neoplasms 26008204 "Association of SNPs in miR-146a, miR-196a2, and miR-499 with the risk of endometrial/ovarian cancer." -genetics_GWAS hsa-mir-509 Colorectal Carcinoma 26010608 These findings suggest that the rs13347C/T in microRNA binding site may be potential biomarkers for genetic susceptibility to CRC. -genetics_GWAS hsa-mir-149 Rheumatoid Arthritis 26032077 "SNP rs22928323 in miR-149 is correlated with RA in the east of Chinese Han population, whereas there is no correlation between miR-149 polymorphism and clinical characteristics in patients with RA." -genetics_GWAS hsa-mir-146a Behcet Disease 26053525 Association of Pre-miRNA-499 rs3746444 and Pre-miRNA-146a rs2910164 Polymorphisms and Susceptibility to Behcet's Disease. -genetics_GWAS hsa-mir-499 Behcet Disease 26053525 Association of Pre-miRNA-499 rs3746444 and Pre-miRNA-146a rs2910164 Polymorphisms and Susceptibility to Behcet's Disease. -genetics_GWAS hsa-mir-4293 "Squamous Cell Carcinoma, Esophageal" 26055141 miR-449b rs10061133 and miR-4293 rs12220909 polymorphisms are associated with decreased esophageal squamous cell carcinoma in a Chinese population. -genetics_GWAS hsa-mir-449b "Squamous Cell Carcinoma, Esophageal" 26055141 miR-449b rs10061133 and miR-4293 rs12220909 polymorphisms are associated with decreased esophageal squamous cell carcinoma in a Chinese population. -genetics_GWAS hsa-mir-155 Melanoma 26068396 Polymorphisms in 3'UTR of TYRP1 mRNA can affect TYRP1 mRNA regulation by miR-155 and its subsequent translation into protein. These SNPs can render TYRP1 mRNA and protein expression nonsusceptible to miR-155 activity and disclose a prognostic value for TYRP1 protein in a subgroup of melanoma patients. These data support the interest in the prognostic value of melanogenic markers and propose TYRP1 to refine prognosis in patients with advanced disease. -genetics_GWAS hsa-mir-146a Lung Neoplasms 26083623 The interactions between miRNA SNPs and cooking oil fume exposure suggested by ORs of different combination were not statistically significant. -genetics_GWAS hsa-mir-196a-2 Lung Neoplasms 26083623 The interactions between miRNA SNPs and cooking oil fume exposure suggested by ORs of different combination were not statistically significant. -genetics_GWAS hsa-mir-27a Lung Neoplasms 26083623 The interactions between miRNA SNPs and cooking oil fume exposure suggested by ORs of different combination were not statistically significant. -genetics_GWAS hsa-mir-423 Lung Neoplasms 26083623 The interactions between miRNA SNPs and cooking oil fume exposure suggested by ORs of different combination were not statistically significant. -genetics_GWAS hsa-mir-608 Lung Neoplasms 26083623 The interactions between miRNA SNPs and cooking oil fume exposure suggested by ORs of different combination were not statistically significant. -genetics_GWAS hsa-mir-146a Alzheimer Disease 26095531 A single nucleotide polymorphism in primary-microRNA-146a reduces the expression of mature microRNA-146a in patients with Alzheimer's disease and is associated with the pathogenesis of Alzheimer's disease. -genetics_GWAS hsa-mir-196a-2 Prostate Neoplasms 26112096 "Assessment of association between genetic variants in microRNA genes hsa-miR-499,hsa-miR-196a2 and hsa-miR-27a and prostate cancer risk in Serbian population." -genetics_GWAS hsa-mir-27a Prostate Neoplasms 26112096 "Assessment of association between genetic variants in microRNA genes hsa-miR-499,hsa-miR-196a2 and hsa-miR-27a and prostate cancer risk in Serbian population." -genetics_GWAS hsa-mir-499 Prostate Neoplasms 26112096 "Assessment of association between genetic variants in microRNA genes hsa-miR-499,hsa-miR-196a2 and hsa-miR-27a and prostate cancer risk in Serbian population." -genetics_GWAS hsa-mir-146a Melanoma 26122011 Association of microRNA 146a polymorphism rs2910164 and the risk of melanoma in an Italian population. -genetics_GWAS hsa-mir-196a-2 Breast Neoplasms 26125831 Our results suggested that miR-146a rs2910164 G>C and miR-196a2 rs11614913 T>C may be biomarkers for predicting breast cancer risk in the Chinese population. -genetics_GWAS hsa-mir-3622a Colorectal Carcinoma 26147304 "Our results indicate variations in RAN rs14035, DICER1 rs3742330, XPO5 rs11077, and DROSHA rs10719 of Korean patients are significantly associated with their risk of CRC." -genetics_GWAS hsa-mir-5582 Colorectal Carcinoma 26147304 "Our results indicate variations in RAN rs14035, DICER1 rs3742330, XPO5 rs11077, and DROSHA rs10719 of Korean patients are significantly associated with their risk of CRC." -genetics_GWAS hsa-mir-125b Breast Neoplasms 26190157 Evaluation the susceptibility of five polymorphisms in microRNA-binding sites to female breast cancer risk in Chinese population. -genetics_GWAS hsa-mir-320 Breast Neoplasms 26190157 Evaluation the susceptibility of five polymorphisms in microRNA-binding sites to female breast cancer risk in Chinese population. -genetics_GWAS hsa-mir-367 Breast Neoplasms 26190157 Evaluation the susceptibility of five polymorphisms in microRNA-binding sites to female breast cancer risk in Chinese population. -genetics_GWAS hsa-mir-570 Viral Infectious Disease 26199425 it was demonstrated that human CYP2E1 was regulated by miR-570 in a genotype-dependent manner. This report describes the first proof that SNP in 3'-UTR of human P450 affects binding of miRNA to modulate the expression in the liver. -genetics_GWAS hsa-mir-146a Pulmonary Hypertension 26202355 "the results of this study demonstrate that the rs2910164 CC and GC genotype is associated with a decreased risk of pulmonary hypertension, which could be attributed to defective miRNA processing and compromised ability to inhibit production of COX-2 and PGI2." -genetics_GWAS hsa-mir-146a Intracranial Aneurysm 26214448 Association between the hsa-miR-146a rs2910164 functional polymorphism with susceptibility to intracranial aneurysm. -genetics_GWAS hsa-mir-146a "Squamous Cell Carcinoma, Oral" 26214637 "The miR-146a rs2910164 polymorphism is associated with increased risk for cervical and skin SCC. In contrast, rs2910164 in miR-146a is related to decreased risk for nasopharyngeal and oral SCC." -genetics_GWAS hsa-mir-483 Colorectal Carcinoma 26235181 Both the single nucleotide polymorphism variants showed a positive association toward risk of lung cancer. -genetics_GWAS hsa-mir-551a Colorectal Carcinoma 26235181 Both the single nucleotide polymorphism variants showed a positive association toward risk of lung cancer. -genetics_GWAS hsa-mir-219 Schizophrenia 26257337 "These findings suggest that GRIN2B may be associated with schizophrenia and interaction effects of the polymorphisms in hsa-miR-219, CAKM2G, GRIN2B and GRIN3A may confer susceptibility to schizophrenia in the Chinese Han population." -genetics_GWAS hsa-mir-100 "Squamous Cell Carcinoma, Esophageal" 26261633 Genetic variation in miR-100 rs1834306 is associated with decreased risk for esophageal squamous cell carcinoma in Kazakh patients in northwest China. -genetics_GWAS hsa-let-7c Essential Hypertension 26274321 "In conclusion, our experimental results provide evidence that the T allele of rs17168525 in the 3'-UTR of myotrophin might influence the level of myotrophin protein by interfering with let-7/miR-98 binding." -genetics_GWAS hsa-mir-503 Essential Hypertension 26274321 "In conclusion, our experimental results provide evidence that the T allele of rs17168525 in the 3'-UTR of myotrophin might influence the level of myotrophin protein by interfering with let-7/miR-98 binding." -genetics_GWAS hsa-mir-98 Essential Hypertension 26274321 "In conclusion, our experimental results provide evidence that the T allele of rs17168525 in the 3'-UTR of myotrophin might influence the level of myotrophin protein by interfering with let-7/miR-98 binding." -genetics_GWAS hsa-mir-146a Head And Neck Neoplasms 26277865 Significant association between functional microRNA polymorphisms and head and neck cancer susceptibility: a comprehensive meta-analysis. -genetics_GWAS hsa-mir-149 Head And Neck Neoplasms 26277865 Significant association between functional microRNA polymorphisms and head and neck cancer susceptibility: a comprehensive meta-analysis. -genetics_GWAS hsa-mir-196a-2 Head And Neck Neoplasms 26277865 Significant association between functional microRNA polymorphisms and head and neck cancer susceptibility: a comprehensive meta-analysis. -genetics_GWAS hsa-mir-499 Head And Neck Neoplasms 26277865 Significant association between functional microRNA polymorphisms and head and neck cancer susceptibility: a comprehensive meta-analysis. -genetics_GWAS hsa-mir-27a Colorectal Carcinoma 26302683 Genotype GG of rs895819 Functional Polymorphism Within miR-27a Might Increase Genetic Susceptibility to Colorectal Cancer in Han Chinese Population -genetics_GWAS hsa-mir-34b Digestive System Neoplasms 26320502 The current evidence supports the conclusion that the miR-34b/c rs4938723 polymorphism decreases an individual's susceptibility to digestive cancers. -genetics_GWAS hsa-mir-146a "Carcinoma, Renal Cell" 26323945 the observed association between the GG and GC genotype and poorer survival rate of RCC was at least partially mediated by the decreased expression of miR-146a. -genetics_GWAS hsa-mir-214 Diabetes Mellitus 26329304 "We have detected the interactions of hsa-miR-214-5p/hsa-miR-550a-5p and the 3'UTR SNP of the HNF1B gene by in vitro luciferase reporter assays, and propose that the binding of such miRNAs regulates the expression of the HNF1B gene and the susceptibility of T2DM." -genetics_GWAS hsa-mir-550a Diabetes Mellitus 26329304 "We have detected the interactions of hsa-miR-214-5p/hsa-miR-550a-5p and the 3'UTR SNP of the HNF1B gene by in vitro luciferase reporter assays, and propose that the binding of such miRNAs regulates the expression of the HNF1B gene and the susceptibility of T2DM." -genetics_GWAS hsa-mir-146a Neoplasms [unspecific] 26337564 We conclude that rs2910164 may represent a valuable biomarker associated with the risk of developing specific types of cancer. -genetics_GWAS hsa-mir-146a Gastric Neoplasms 26345764 "Overall, this meta-analysis failed to detect an association between five common miR-146a gene polymorphisms and GC susceptibility. However, this does not necessarily completely rule out a correlation between miRNA polymorphisms and GC susceptibility." -genetics_GWAS hsa-mir-149 Gastric Neoplasms 26345764 "Overall, this meta-analysis failed to detect an association between five common miR-146a gene polymorphisms and GC susceptibility. However, this does not necessarily completely rule out a correlation between miRNA polymorphisms and GC susceptibility." -genetics_GWAS hsa-mir-196a-2 Gastric Neoplasms 26345764 "Overall, this meta-analysis failed to detect an association between five common miR-146a gene polymorphisms and GC susceptibility. However, this does not necessarily completely rule out a correlation between miRNA polymorphisms and GC susceptibility." -genetics_GWAS hsa-mir-27a Gastric Neoplasms 26345764 "Overall, this meta-analysis failed to detect an association between five common miR-146a gene polymorphisms and GC susceptibility. However, this does not necessarily completely rule out a correlation between miRNA polymorphisms and GC susceptibility." -genetics_GWAS hsa-mir-499 Gastric Neoplasms 26345764 "Overall, this meta-analysis failed to detect an association between five common miR-146a gene polymorphisms and GC susceptibility. However, this does not necessarily completely rule out a correlation between miRNA polymorphisms and GC susceptibility." -genetics_GWAS hsa-mir-146a Gastric Neoplasms 26345790 "In summary, the results suggested that the miR-146a rs2910164 polymorphism was related to gastric cancer risk in Asians but not in Caucasians, and no distinct correlation seemed to exist between the miR-196a-2 rs11614913 polymorphism and the risk of gastric cancer." -genetics_GWAS hsa-mir-196a-2 Gastric Neoplasms 26345790 "In summary, the results suggested that the miR-146a rs2910164 polymorphism was related to gastric cancer risk in Asians but not in Caucasians, and no distinct correlation seemed to exist between the miR-196a-2 rs11614913 polymorphism and the risk of gastric cancer." -genetics_GWAS hsa-mir-196a-2 "Carcinoma, Hepatocellular" 26365437 "In conclusion,the donor miR-196a-2 rs11614913 polymorphism is associated with HCC recurrence after LT and improves the predictive value of clinical models. The overexpression of miR-196a in the liver might provide a tumor-favorable environment for the development of HCC." -genetics_GWAS hsa-mir-219-1 "Squamous Cell Carcinoma, Esophageal" 26379361 These findings indicated that functional polymorphisms miR-219-1 rs107822G > A might change individual susceptibility to Kazakh ESCC. -genetics_GWAS hsa-mir-505 Gastric Neoplasms 26394032 "The PSMD10 rs111638916 SNP is highly associated with an increased risk of GC in Chinese patients, and could serve as a novel biomarker for this disease." -genetics_GWAS hsa-mir-34b "Carcinoma, Thyroid, Papillary" 26402809 These findings indicate that the miR-34b/c rs4938723 and TP-53 Arg72Pro polymorphisms may contribute to the susceptibility of PTC. -genetics_GWAS hsa-mir-34c "Carcinoma, Thyroid, Papillary" 26402809 These findings indicate that the miR-34b/c rs4938723 and TP-53 Arg72Pro polymorphisms may contribute to the susceptibility of PTC. -genetics_GWAS hsa-mir-196a-2 Gastric Neoplasms 26406571 "Our studies suggested that the miR-146a rs2910164 polymorphism might marginally contribute to a decreased risk of gastric cancer, especially in Caucasians, whereas the miR-196a2 rs11614913 polymorphism might not be associated with susceptibility to GC." -genetics_GWAS hsa-mir-155 Epilepsy 26425555 "This study first demonstrates the association of MIR155HG/miR-155 tag SNPs with epilepsy and shows that rare CNVs were found exclusively in epileptic patients, clarifying the genetic role of miR-155 in epilepsy." -genetics_GWAS hsa-mir-146a Kidney Diseases [unspecific] 26426696 "There was no association of rs2910164 with susceptibility to IgAN in adults from a Chinese Han population. However, rs2910164 was correlated with the age of onset of IgAN in adult patients." -genetics_GWAS hsa-mir-137 Schizophrenia 26429811 A GWAS SNP for Schizophrenia Is Linked to the Internal MIR137 Promoter and Supports Differential Allele-Specific Expression. -genetics_GWAS hsa-mir-101-1 "Carcinoma, Hepatocellular" 26434859 "Our results revealed no significant association between miR-149 (rs2292832) and miR-101-1 (rs7536540) and the risk of HCC in our Thai population.However, this research is the first study of miR-149 (rs2292832) and miR-101-1 (rs7536541) in HCC in Thai populations and the results need to be confirmed with a larger population." -genetics_GWAS hsa-mir-149 "Carcinoma, Hepatocellular" 26434859 "Our results revealed no significant association between miR-149 (rs2292832) and miR-101-1 (rs7536540) and the risk of HCC in our Thai population.However, this research is the first study of miR-149 (rs2292832) and miR-101-1 (rs7536540) in HCC in Thai populations and the results need to be confirmed with a larger population." -genetics_GWAS hsa-mir-146a "Carcinoma, Cervical" 26464690 "The miR-146a (rs2910164) polymorphism is significantly correlated to ethnic factor and tumor diameters. miR-146a has differential expression in cervical tissues. Allele G of miR-146a (rs2910164) is related to the high expression of miR-146a, and the progression of cervical cancer." -genetics_GWAS hsa-mir-196a-2 "Carcinoma, Hepatocellular" 26464719 "In conclusion, miR-196a2 rs11614913 polymorphism may contribute to identifying individuals, especially in HBV-infected subjects, who are at high risk for HCC." -genetics_GWAS hsa-mir-92a Breast Neoplasms 26471763 "MDM4 SNP34091 status to be associated with reduced risk of breast cancer, in particular in individuals carrying the MDM2 SNP309GG genotype, but not to be associated with either lung-, colon- or prostate cancer." -genetics_GWAS hsa-mir-146a Breast Neoplasms 26476291 The microRNA miR146a has a potential role in the development of breast cancer and the effects of its SNPs require further inquiry to determine the nature of their influence on breast tissue and cancer. -genetics_GWAS hsa-mir-34b Male Infertility 26505368 Our results indicated that the MTHFR 3'-UTR rs55763075 polymorphism might modify the susceptibility to male infertility with idiopathic azoospermia. -genetics_GWAS hsa-mir-146a Carotid Atherosclerosis 26505665 "The miR-146a rs2910164 polymorphism might be associated with carotid vulnerable plaque risk in Chinese type 2 diabetes mellitus patients, particularly in older patients, females, those with diabetes duration of more than 10 years and those with hypertension. The transcriptional coactivator p300 rs20551 polymorphism may not be a risk factor for the development or progression of atherosclerosis in type 2 diabetes mellitus." -genetics_GWAS hsa-mir-423 "Squamous Cell Carcinoma, Esophageal" 26518769 "Four SNPs including miR-196a2 rs11614913, miR-146a rs2910164, miR-499 rs3746444, and miR-423 rs6505162 were selected with comprehensive collection strategy and genotyped using the SNaPshot Multiplex System." -genetics_GWAS hsa-let-7 Hematologic Neoplasms 26520014 our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies. -genetics_GWAS hsa-mir-146 Hematologic Neoplasms 26520014 our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies. -genetics_GWAS hsa-mir-150 Hematologic Neoplasms 26520014 our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies. -genetics_GWAS hsa-mir-155 Hematologic Neoplasms 26520014 our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies. -genetics_GWAS hsa-mir-15a Hematologic Neoplasms 26520014 our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies. -genetics_GWAS hsa-mir-16-1 Hematologic Neoplasms 26520014 our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies. -genetics_GWAS hsa-mir-21 Hematologic Neoplasms 26520014 our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies. -genetics_GWAS hsa-mir-221 Hematologic Neoplasms 26520014 our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies. -genetics_GWAS hsa-mir-222 Hematologic Neoplasms 26520014 our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies. -genetics_GWAS hsa-mir-29 Hematologic Neoplasms 26520014 our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies. -genetics_GWAS hsa-mir-34 Hematologic Neoplasms 26520014 our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies. -genetics_GWAS hsa-mir-372 Hematologic Neoplasms 26520014 our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies. -genetics_GWAS hsa-mir-373 Hematologic Neoplasms 26520014 our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies. -genetics_GWAS hsa-mir-708 Hematologic Neoplasms 26520014 our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies. -genetics_GWAS hsa-mir-196a-2 Liver Cirrhosis 26529280 "In summary, rs12304647 is associated with a reduced risk of progression to HCC in patients with chronic HBV infection." -genetics_GWAS hsa-mir-146a Acute Coronary Syndrome 26537765 These findings indicate that miR-146a rs2910164 may act as a novel molecular marker for ACS susceptibility. -genetics_GWAS hsa-mir-196a-2 Atrial Fibrillation 26554236 "Our data support that the pre-miR-196a2 polymorphism is associated with AF, and the C allele is a risk factor for AF." -genetics_GWAS hsa-mir-125 Diabetic Nephropathy 26563755 "We identified miR-125a as a direct regulator of IL-6R, and the genotype of rs12976445 might be a novel predictor of the development of DN in DM." -genetics_GWAS hsa-mir-145 Breast Neoplasms 26577090 Our study is the first to report an association between a miR-SNP in MIR145 and breast cancer risk in individuals of Caucasian background. This finding requires further validation through genotyping of larger cohorts or in individuals of different ethnicities to determine the potential significance of this finding as well as studies aimed to determine functional significance. -genetics_GWAS hsa-mir-499 Gastric Neoplasms 26597478 The present study indicated that miR-499 rs3746444 might contribute to GC risk and this SNP could be developed as a biomarker for GC prediction. -genetics_GWAS hsa-mir-146a "Stroke, Ischemic" 26608782 "Although the 3 SNPs might be associated with IS, the association varied significantly in different countries." -genetics_GWAS hsa-mir-196a-2 "Stroke, Ischemic" 26608782 "Although the 3 SNPs might be associated with IS, the association varied significantly in different countries." -genetics_GWAS hsa-mir-499 "Stroke, Ischemic" 26608782 "Although the 3 SNPs might be associated with IS, the association varied significantly in different countries." -genetics_GWAS hsa-mir-149 "Squamous Cell Carcinoma, Oral" 26625766 Our study suggests that miR-196a2C>T and miR-149C>T polymorphisms may play crucial roles in the development of OSCC in South Indian subjects. -genetics_GWAS hsa-mir-124 Neoplasms [unspecific] 26625819 This meta-analysis suggests that the miR-124 rs531564 C > G polymorphism is an important risk factor for cancers among the Chinese population. -genetics_GWAS hsa-let-7a "Carcinoma, Colon" 26630397 "Of the 327 SNPs identified in the literature as being important because of their potential regulation of miRNA expression levels, 12.5% had statistically significantly associations with miRNA expression. However, only two of these SNPs were significantly associated with colon cancer." -genetics_GWAS hsa-mir-143 "Carcinoma, Colon" 26630397 "Of the 327 SNPs identified in the literature as being important because of their potential regulation of miRNA expression levels, 12.5% had statistically significantly associations with miRNA expression. However, only two of these SNPs were significantly associated with colon cancer." -genetics_GWAS hsa-mir-145 "Carcinoma, Colon" 26630397 "Of the 327 SNPs identified in the literature as being important because of their potential regulation of miRNA expression levels, 12.5% had statistically significantly associations with miRNA expression. However, only two of these SNPs were significantly associated with colon cancer." -genetics_GWAS hsa-mir-146a "Carcinoma, Colon" 26630397 "Of the 327 SNPs identified in the literature as being important because of their potential regulation of miRNA expression levels, 12.5% had statistically significantly associations with miRNA expression. However, only two of these SNPs were significantly associated with colon cancer." -genetics_GWAS hsa-mir-19a "Carcinoma, Colon" 26630397 "Of the 327 SNPs identified in the literature as being important because of their potential regulation of miRNA expression levels, 12.5% had statistically significantly associations with miRNA expression. However, only two of these SNPs were significantly associated with colon cancer." -genetics_GWAS hsa-mir-19b "Carcinoma, Colon" 26630397 "Of the 327 SNPs identified in the literature as being important because of their potential regulation of miRNA expression levels, 12.5% had statistically significantly associations with miRNA expression. However, only two of these SNPs were significantly associated with colon cancer." -genetics_GWAS hsa-mir-214 "Carcinoma, Colon" 26630397 "Of the 327 SNPs identified in the literature as being important because of their potential regulation of miRNA expression levels, 12.5% had statistically significantly associations with miRNA expression. However, only two of these SNPs were significantly associated with colon cancer." -genetics_GWAS hsa-mir-25 "Carcinoma, Colon" 26630397 "Of the 327 SNPs identified in the literature as being important because of their potential regulation of miRNA expression levels, 12.5% had statistically significantly associations with miRNA expression. However, only two of these SNPs were significantly associated with colon cancer." -genetics_GWAS hsa-mir-525 "Carcinoma, Colon" 26630397 "Of the 327 SNPs identified in the literature as being important because of their potential regulation of miRNA expression levels, 12.5% had statistically significantly associations with miRNA expression. However, only two of these SNPs were significantly associated with colon cancer." -genetics_GWAS hsa-mir-140 Bladder Neoplasms 26695686 "Together, these results suggest that rs35592567 in TP63 may be a novel causal variant contributing to the susceptibility to bladder cancer, which provides additional insight into the pathogenesis of bladder carcinogenesis." -genetics_GWAS hsa-mir-196a-2 Breast Neoplasms 26710106 Somatic Mutation of the SNP rs11614913 and Its Association with Increased MIR 196A2 Expression in Breast Cancer. -genetics_GWAS hsa-mir-603 Breast Neoplasms 26718432 "In conclusion,the findings indicated that Mir603 rs11014002 T allele might contribute to decrease the risk of BC in a sample of Iranian population. Further studies with larger sample sizes and different ethnicities are warranted to confirm our findings." -genetics_GWAS hsa-mir-449a Gastric Neoplasms 26722545 "In conclusion, our findings suggest that miR-449a rs112310158 is a genetic risk factor for GC." -genetics_GWAS hsa-mir-146a "Carcinoma, Thyroid, Papillary" 26722556 "Our study indicated that the miR-146a polymorphism was significantly associated with PTC risk. In contrast, meta-analysis revealed no evidence of association between miR-146a variants and PTC risk. Further studies are required to elucidate the role of miR-146a in the etiology of PTC." -genetics_GWAS hsa-mir-492 "Carcinoma, Hepatocellular" 26753964 miR-492G>C polymorphism (rs2289030) is associated with overall survival of hepatocellular carcinoma patients. -genetics_GWAS hsa-mir-146a Breast Neoplasms 26785832 "e identified one rare variant in MIR146A, four in MIR146B, five in BRCA1 3'-UTR and one in BRCA2 3'-UTR in 716 index cases and 619 controls." -genetics_GWAS hsa-mir-146a Ovarian Neoplasms 26785832 "e identified one rare variant in MIR146A, four in MIR146B, five in BRCA1 3'-UTR and one in BRCA2 3'-UTR in 716 index cases and 619 controls." -genetics_GWAS hsa-mir-146b Breast Neoplasms 26785832 "we identified one rare variant in MIR146A, four in MIR146B, five in BRCA1 3'-UTR and one in BRCA2 3'-UTR in 716 index cases and 619 controls." -genetics_GWAS hsa-mir-146b Ovarian Neoplasms 26785832 "we identified one rare variant in MIR146A, four in MIR146B, five in BRCA1 3'-UTR and one in BRCA2 3'-UTR in 716 index cases and 619 controls." -genetics_GWAS hsa-mir-146a Colorectal Carcinoma 26813595 "SNPs in the miRNA genes are important for tumorigenesis. The changes by hsa-mir-146a rs1052918 C>G may result in loss of Wnt, constant activation of the Wnt signaling pathway, and uncontrolled cell proliferation and tumor progression." -genetics_GWAS hsa-mir-608 "Carcinoma, Hepatocellular" 26815502 MiR-608 rs4919510 is associated with prognosis of hepatocellular carcinoma. -genetics_GWAS hsa-mir-149 "Carcinoma, Hepatocellular" 26823863 "Predictive role of miR-146a rs2910164 (C>G), miR-149 rs2292832 (T>C), miR-196a2 rs11614913 (T>C) and miR-499 rs3746444 (T>C) in the development of hepatocellular carcinoma." -genetics_GWAS hsa-mir-137 Schizophrenia 26836412 Polymorphisms in MIR137HG and microRNA-137-regulated genes influence gray matter structure in schizophrenia. -genetics_GWAS hsa-mir-199a "Adenocarcinoma, Pancreatic Ductal" 26872370 our study demonstrates that host genetic variants could disturb the regulation of the miR-199a/HIF1A regulatory loop and alter PDAC risk and poor prognosis. -genetics_GWAS hsa-mir-146a Atherosclerosis 26875519 Apolipoprotein E Epsilon 4 Enhances the Association between the rs2910164 Polymorphism of miR-146a and Risk of Atherosclerotic Cerebral Infarction. -genetics_GWAS hsa-mir-146a Coronary Artery Disease 26909569 "Our data provide the first evidence for the association of miR-146a rs2910164 and TCF21 rs12190287 with CAD in an Iranian population, encouraging further research to elucidate the disease-related effects of miR-146a rs2910164." -genetics_GWAS hsa-mir-146a Lung Neoplasms 26926727 "Rs11614913, rs12894467 and rs2910164 polymorphism were potentially associated with primary lung cancer in Fujian Han population." -genetics_GWAS hsa-mir-196a-2 Lung Neoplasms 26926727 "Rs11614913, rs12894467 and rs2910164 polymorphism were potentially associated with primary lung cancer in Fujian Han population." -genetics_GWAS hsa-mir-26a-1 Lung Neoplasms 26926727 "Rs11614913, rs12894467 and rs2910164 polymorphism were potentially associated with primary lung cancer in Fujian Han population." -genetics_GWAS hsa-mir-27a Lung Neoplasms 26926727 "Rs11614913, rs12894467 and rs2910164 polymorphism were potentially associated with primary lung cancer in Fujian Han population." -genetics_GWAS hsa-mir-300 Lung Neoplasms 26926727 "Rs11614913, rs12894467 and rs2910164 polymorphism were potentially associated with primary lung cancer in Fujian Han population." -genetics_GWAS hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 26959643 mutations in the mir-15a/16-1 loci are responsible for decreased expression -genetics_GWAS hsa-mir-423 Lung Neoplasms 26973201 These findings suggest that miR-146a rs2910164C>G and miR-423 rs6505162C>A polymorphisms may contribute to genetic susceptibility to lung cancer and lung adenocarcinoma in Chinese non-smoking females. -genetics_GWAS hsa-mir-146a Diabetic Nephropathy 26997512 Rs2910164 is significantly associated with microvascular complications DN in patients with T1DM and DME in patients with T2DM. -genetics_GWAS hsa-mir-146a Diabetic Retinopathy 26997512 Rs2910164 is significantly associated with microvascular complications DN in patients with T1DM and DME in patients with T2DM. -genetics_GWAS hsa-mir-618 "Stroke, Ischemic" 27011381 Our findings suggest that miR-618 SNP rs2682818 may play an important role in the recurrence of ischemic stroke. -genetics_GWAS hsa-mir-149 Squamous Cell Carcinoma 27050146 hsa-mir-149 rs2292832 and hsa-mir-499 rs3746444 polymorphisms play a significant role in the prognosis of SCCNOP -genetics_GWAS hsa-mir-365 Neuropsychiatric Disorders [unspecific] 27074815 single nucleotide polymorphism (SNP) rs2235749 (in high linkage disequilibrium with rs910080) modifies striatal PDYN expression via impaired binding of miR-365 -genetics_GWAS hsa-mir-137 Schizophrenia 27096222 A single nucleotide polymorphism rs1625579 in the miR-137 gene has recently been reported to confer risk of schizophrenia -genetics_GWAS hsa-mir-146a Psoriasis 27098222 "The miR-146a SNPs rs2910164, rs57095329, rs2431697 are associated with susceptibility to certain autoimmune diseases." -genetics_GWAS hsa-mir-149 "Carcinoma, Hepatocellular" 27141902 "A meta-analysis of microRNA-149, microRNA-499 gene polymorphism and susceptibility to hepatocellular carcinoma" -genetics_GWAS hsa-mir-146a Graft-Versus-Host Disease 27156151 "expression levels of miR-146aC>G, miR-196a2T>C and putative gene-gene interaction between miR-146a, miR-196a2, miR-149 may be involved in RIF development in Korean women." -genetics_GWAS hsa-mir-149 Graft-Versus-Host Disease 27156151 "expression levels of miR-146aC>G, miR-196a2T>C and putative gene-gene interaction between miR-146a, miR-196a2, miR-149 may be involved in RIF development in Korean women." -genetics_GWAS hsa-mir-196a-2 Graft-Versus-Host Disease 27156151 "expression levels of miR-146aC>G, miR-196a2T>C and putative gene-gene interaction between miR-146a, miR-196a2, miR-149 may be involved in RIF development in Korean women." -genetics_GWAS hsa-mir-499a Graft-Versus-Host Disease 27156151 "expression levels of miR-146aC>G, miR-196a2T>C and putative gene-gene interaction between miR-146a, miR-196a2, miR-149 may be involved in RIF development in Korean women." -genetics_GWAS hsa-mir-124 Mesial Temporal Lobe Epilepsy 27188998 "In this study, the effect of the SNP of one neuronal miRNA, miR-124, on susceptibility to MTLE was investigated using a case control study." -genetics_GWAS hsa-mir-34b Osteoporosis 27227383 The present findings indicate that pri-miR-34b/c rs4938723 and TP53 Arg72Pro polymorphisms may contribute to the risk of OP. -genetics_GWAS hsa-mir-34c Osteoporosis 27227383 The present findings indicate that pri-miR-34b/c rs4938723 and TP53 Arg72Pro polymorphisms may contribute to the risk of OP. -genetics_GWAS hsa-let-7 Colorectal Carcinoma 27234654 rs868 is associated with lower TGFBR1 expression thereby increasing CRC risk. -genetics_GWAS hsa-mir-130a "Stroke, Ischemic" 27246008 "Association of miR-34a, miR-130a, miR-150 and miR-155 polymorphisms with the risk of ischemic stroke" -genetics_GWAS hsa-mir-150 "Stroke, Ischemic" 27246008 "Association of miR-34a, miR-130a, miR-150 and miR-155 polymorphisms with the risk of ischemic stroke" -genetics_GWAS hsa-mir-155 "Stroke, Ischemic" 27246008 "Association of miR-34a, miR-130a, miR-150 and miR-155 polymorphisms with the risk of ischemic stroke" -genetics_GWAS hsa-mir-34a "Stroke, Ischemic" 27246008 "Association of miR-34a, miR-130a, miR-150 and miR-155 polymorphisms with the risk of ischemic stroke" -genetics_GWAS hsa-mir-146a Gastric Neoplasms 27267319 rs2910164 of miR-146a is associated with GC -genetics_GWAS hsa-mir-27a "Diabetes Mellitus, Type 2" 27300034 The pre-mir-27a variant rs895819 may contribute to type 2 diabetes mellitus susceptibility -genetics_GWAS hsa-mir-501 "Carcinoma, Hepatocellular" 27310251 We identified a novel SNP located in miR-501 acting as an important factor of the HCC susceptibility -genetics_GWAS hsa-mir-214 "Squamous Cell Carcinoma, Esophageal" 27323028 esophageal squamous cell carcinoma -genetics_GWAS hsa-mir-146a Rheumatoid Arthritis 27342690 12 single nucleotide polymorphisms -genetics_GWAS hsa-mir-502 "Carcinoma, Renal Cell, Clear-Cell" 27346408 Polymorphism at the miR-502 binding site in the 3' untranslated region of SET8 gene is associated with the risk of clear cell renal cell carcinoma -genetics_GWAS hsa-mir-149 "Carcinoma, Hepatocellular" 27348444 MIR-149 gene rs2292832 polymorphism contributed to the risk of HCC -genetics_GWAS hsa-mir-370 Colorectal Carcinoma 27354594 "rs2279398G>A may affect the expression of DOK3 by altering the miRNA binding efficiency at the miRNA-binding sites of the 3'-UTR in DOK3, thereby impacting CRC tumorigenesis." -genetics_GWAS hsa-mir-1273d Tooth Agenesis 27362534 our findings indicate that rs15705 and rs317250 are associated with the susceptibility of non-syndromic tooth agenesis by possibly affecting miRNAs and mRNA interaction. -genetics_GWAS hsa-mir-4639 Tooth Agenesis 27362534 rs15705 and rs317250 are associated with the susceptibility of non-syndromic tooth agenesis by possibly affecting miRNAs and mRNA interaction. -genetics_GWAS hsa-mir-429 "Carcinoma, Lung, Non-Small-Cell" 27374108 rs9660710 in miR-200b/200a/429 cluster and rs763354 in miR-30a might modify the susceptibility to NSCLC. -genetics_GWAS hsa-mir-146a Hypertension 27379568 "This study suggests that the variant of miR-146aC>G polymorphism and allelic combinations, at least in Koreans, affect susceptibility to hypertension." -genetics_GWAS hsa-mir-6826 Breast Neoplasms 27380242 "We systematically put together a list of 822 and 10,468 genetic variants among primary miRNA sequences and 38 genes in the miRNA biogenesis pathway" -genetics_GWAS hsa-mir-608 Rectal Neoplasms 27381831 Sequence variation in mature microRNA-608 and benefit from neo-adjuvant treatment in locally advanced rectal cancer patients. -genetics_GWAS hsa-mir-152 Asthma 27383317 Single nucleotide polymorphisms in the promoter region of mir-133a-1 and in pre-mir-152 rs1707 may contribute to the risk of asthma in a Chinese Han population. -genetics_GWAS hsa-mir-142 "Lymphoma, Follicular" 27389057 "We found recurrent mutations of miR-142, which has not been previously been reported to be mutated in FL/tFL." -genetics_GWAS hsa-mir-142 "Lymphoma, Large B-Cell, Diffuse" 27390358 "Additionally, we detected recurrent mutations of hsa-miR-142 in diffuse large B-cell lymphomas and follicular lymphomas, and editing of the hsa-miR-376 cluster, providing evidence for microRNA editing in lymphomagenesis." -genetics_GWAS hsa-mir-376 "Lymphoma, Large B-Cell, Diffuse" 27390358 "we detected recurrent mutations of hsa-miR-142 in diffuse large B-cell lymphomas and follicular lymphomas, and editing of the hsa-miR-376 cluster, providing evidence for microRNA editing in lymphomagenesis." -genetics_GWAS hsa-mir-483 "Squamous Cell Carcinoma, Esophageal" 27420938 SNP at miR-483-5p-binding site in the 3'-untranslated region of the BSG gene is associated with susceptibility to esophageal cancer in a Chinese population. -genetics_GWAS hsa-mir-584 Pemphigus 27424220 "Collectively, these results suggest that a disease-associated SNP located within the 3'UTR of KLRG1 directly interferes with miR-584-5p binding, allowing for KLRG1 mRNA differential accumulation, which in turn may contribute to pathogenesis of autoimmune diseases, such as pemphigus." -genetics_GWAS hsa-mir-206 Schizophrenia 27424800 Our study therefore suggests that miR-206 may contribute to schizophrenia risk through allele-dependent regulation of the genome-wide significant gene NT5C2. -genetics_GWAS hsa-let-7a Osteosarcoma 27430246 "Taken together, the findings of the present study demonstrated that the KRAS 3'-UTR rs61764370 polymorphism interfered with miRNA/mRNA interaction, and showed that the minor allele was associated with an elevated risk of developing metastatic disease in OS." -genetics_GWAS hsa-mir-146a Coronary Artery Disease 27430349 "miRNA polymorphisms (miRâ€?46a, miRâ€?49, miRâ€?96a2 and miRâ€?99) are associated with the risk of coronary artery disease." -genetics_GWAS hsa-mir-149 Coronary Artery Disease 27430349 "miRNA polymorphisms (miRâ€?46a, miRâ€?49, miRâ€?96a2 and miRâ€?99) are associated with the risk of coronary artery disease." -genetics_GWAS hsa-mir-196a-2 Coronary Artery Disease 27430349 "miRNA polymorphisms (miRâ€?46a, miRâ€?49, miRâ€?96a2 and miRâ€?99) are associated with the risk of coronary artery disease." -genetics_GWAS hsa-mir-499 Coronary Artery Disease 27430349 "miRNA polymorphisms (miRâ€?46a, miRâ€?49, miRâ€?96a2 and miRâ€?99) are associated with the risk of coronary artery disease." -genetics_GWAS hsa-mir-146a Asthma 27431205 "The miRâ€?46a rs2910164 polymorphism CC genotype was identified to be significantly associated with a decreased risk of BHR in response to intubation when compared with the GG or GC genotype (odds ratio, 0.38; confidence interval, 0.18â€?.78)." -genetics_GWAS hsa-mir-125b Cataract 27431420 rs78378222 polymorphism in the 3'-untranslated region of TP53 contributes to development of age-associated cataracts by modifying microRNA-125b-induced apoptosis of lens epithelial cells. -genetics_GWAS hsa-mir-146a Breast Neoplasms 27434289 "Logistic regression data represented the C allele of rs2910164 (OR = 4.00, p= 0.0037) as the risk allele and associated with Her2-positive phenotype." -genetics_GWAS hsa-mir-143 Bladder Neoplasms 27438131 These findings suggest that the functional rs353293 polymorphism may be a useful biomarker to predict the risk of bladder cancer. -genetics_GWAS hsa-mir-145 Bladder Neoplasms 27438131 These findings suggest that the functional rs353293 polymorphism may be a useful biomarker to predict the risk of bladder cancer. -genetics_GWAS hsa-mir-145 Colorectal Carcinoma 27444415 These findings indicate that the rs353292 polymorphism is functional and may be a risk factor for the development of CRC. -genetics_GWAS hsa-mir-499 "Carcinoma, Hepatocellular" 27453271 miR-499 rs3746444 was significantly associated with an increased the risk of HCC. -genetics_GWAS hsa-mir-146a Ossification of Posterior Longitudinal Ligament 27454313 The miR-146a/-149/-196a2/-499 allele combinations may be a genetic risk factor for cervical OPLL in the Korean population. -genetics_GWAS hsa-mir-149 Ossification of Posterior Longitudinal Ligament 27454313 The miR-146a/-149/-196a2/-499 allele combinations may be a genetic risk factor for cervical OPLL in the Korean population. -genetics_GWAS hsa-mir-196a-2 Ossification of Posterior Longitudinal Ligament 27454313 The miR-146a/-149/-196a2/-499 allele combinations may be a genetic risk factor for cervical OPLL in the Korean population. -genetics_GWAS hsa-mir-499 Ossification of Posterior Longitudinal Ligament 27454313 The results indicate that GG genotype of miR-499 is associated with significantly higher risks of OPLL in the segmental OPLL group. -genetics_GWAS hsa-mir-196a-2 Asthma 27487239 microRNA-196a2 rs11614913 polymorphism might be associated with asthma severity in our sample of the Egyptian population. -genetics_GWAS hsa-mir-149 "Squamous Cell Carcinoma, Head and Neck" 27515039 "However, no significant association was detected between the other three SNPs (miR-149 rs2292832, miR-146a rs2910164, and miR-608 rs4919510) and HNSCC risk." -genetics_GWAS hsa-mir-1269b "Carcinoma, Oral" 27525378 "Genetic variants in microRNA-146a (C>G) and microRNA-1269b (G>C) are associated with the decreased risk of oral premalignant lesions, oral cancer, and pharyngeal cancer." -genetics_GWAS hsa-mir-146a "Carcinoma, Oral" 27525378 "Genetic variants in microRNA-146a (C>G) and microRNA-1269b (G>C) are associated with the decreased risk of oral premalignant lesions, oral cancer, and pharyngeal cancer." -genetics_GWAS hsa-mir-137 Schizophrenia 27525637 "Genome-wide association studies (GWAS) have identified a region at chromosome 1p21.3, containing the microRNA MIR137, to be among the most significant associations for schizophrenia." -genetics_GWAS hsa-let-7 "Stroke, Ischemic" 27530126 An rs13293512 polymorphism in the promoter of let-7 is associated with a reduced risk of ischemic stroke. -genetics_GWAS hsa-mir-155 Neoplasms [unspecific] 27531892 Our findings suggested that miR-155 and its functional variant rs767649 might contribute to the increased risk and poor prognosis of HCC -genetics_GWAS hsa-mir-182 Glaucoma 27537254 A Common Variant in MIR182 Is Associated With Primary Open-Angle Glaucoma in the NEIGHBORHOOD Consortium. -genetics_GWAS hsa-mir-27a Obesity 27537871 MicroRNAs and Drinking: Association between the Pre-miR-27a rs895819 Polymorphism and Alcohol Consumption in a Mediterranean Population. -genetics_GWAS hsa-mir-124a Osteosarcoma 27540978 Single nucleotide polymorphism of hsa-miR-124a affects risk and prognosis of osteosarcoma. -genetics_GWAS hsa-mir-526b "Squamous Cell Carcinoma, Esophageal" 27583835 A genetic polymorphism at miR-526b binding-site in the lincRNA-NR_024015 exon confers risk of esophageal squamous cell carcinoma in a population of North China. -genetics_GWAS hsa-mir-130b "Stroke, Ischemic" 27603512 "Association of the Single Nucleotide Polymorphisms in microRNAs 130b, 200b, and 495 with Ischemic Stroke Susceptibility and Post-Stroke Mortality." -genetics_GWAS hsa-mir-200b "Stroke, Ischemic" 27603512 "Association of the Single Nucleotide Polymorphisms in microRNAs 130b, 200b, and 495 with Ischemic Stroke Susceptibility and Post-Stroke Mortality." -genetics_GWAS hsa-mir-495 "Stroke, Ischemic" 27603512 "Association of the Single Nucleotide Polymorphisms in microRNAs 130b, 200b, and 495 with Ischemic Stroke Susceptibility and Post-Stroke Mortality." -genetics_GWAS hsa-mir-200b "Carcinoma, Breast" 27609814 "Mutation of putative miRNA-binding sites (miR-374a/b, miR-200b/c, miR-29a/b/c, miR-488) in these regions did not have significant impact on 3'UTR activity" -genetics_GWAS hsa-mir-200c "Carcinoma, Breast" 27609814 "Mutation of putative miRNA-binding sites (miR-374a/b, miR-200b/c, miR-29a/b/c, miR-488) in these regions did not have significant impact on 3'UTR activity" -genetics_GWAS hsa-mir-29a "Carcinoma, Breast" 27609814 "Mutation of putative miRNA-binding sites (miR-374a/b, miR-200b/c, miR-29a/b/c, miR-488) in these regions did not have significant impact on 4'UTR activity" -genetics_GWAS hsa-mir-29b "Carcinoma, Breast" 27609814 "Mutation of putative miRNA-binding sites (miR-374a/b, miR-200b/c, miR-29a/b/c, miR-488) in these regions did not have significant impact on 5'UTR activity" -genetics_GWAS hsa-mir-374a "Carcinoma, Breast" 27609814 "Mutation of putative miRNA-binding sites (miR-374a/b, miR-200b/c, miR-29a/b/c, miR-488) in these regions did not have significant impact on 6'UTR activity" -genetics_GWAS hsa-mir-374b "Carcinoma, Breast" 27609814 "Mutation of putative miRNA-binding sites (miR-374a/b, miR-200b/c, miR-29a/b/c, miR-488) in these regions did not have significant impact on 7'UTR activity" -genetics_GWAS hsa-mir-488 "Carcinoma, Breast" 27609814 "Mutation of putative miRNA-binding sites (miR-374a/b, miR-200b/c, miR-29a/b/c, miR-488) in these regions did not have significant impact on 8'UTR activity" -genetics_GWAS hsa-mir-214 "Carcinoma, Hepatocellular" 27619679 U/G SNP rs111904020 in 3'UTR of STAT3 regulated by miR-214 promotes hepatocellular carcinoma development in Chinese population. -genetics_GWAS hsa-mir-149 Lung Neoplasms 27685326 MicroRNA-149 rs2292832 polymorphism may not be associated with lung cancer risk in Chinese non-smoking female -genetics_GWAS hsa-mir-146a "Carcinoma, Ovarian" 27706635 miR-146a and miR-196a2 polymorphisms in ovarian cancer risk. -genetics_GWAS hsa-mir-196a-2 "Carcinoma, Ovarian" 27706635 miR-146a and miR-196a2 polymorphisms in ovarian cancer risk. -genetics_GWAS hsa-mir-146a "Carcinoma, Colon" 27706637 MicroRNA variants and colorectal cancer risk: a meta-analysis. -genetics_GWAS hsa-mir-149 "Carcinoma, Colon" 27706637 MicroRNA variants and colorectal cancer risk: a meta-analysis. -genetics_GWAS hsa-mir-196a "Carcinoma, Colon" 27706637 MicroRNA variants and colorectal cancer risk: a meta-analysis. -genetics_GWAS hsa-mir-27a "Carcinoma, Colon" 27706637 MicroRNA variants and colorectal cancer risk: a meta-analysis. -genetics_GWAS hsa-mir-499 "Carcinoma, Colon" 27706637 MicroRNA variants and colorectal cancer risk: a meta-analysis. -genetics_GWAS hsa-mir-146a "Carcinoma, Hepatocellular" 27706712 "Contributions of polymorphisms in miR146a, miR196a, and miR499 to the development of hepatocellular carcinoma." -genetics_GWAS hsa-mir-196a "Carcinoma, Hepatocellular" 27706712 "Contributions of polymorphisms in miR146a, miR196a, and miR499 to the development of hepatocellular carcinoma." -genetics_GWAS hsa-mir-499 "Carcinoma, Hepatocellular" 27706712 "Contributions of polymorphisms in miR146a, miR196a, and miR499 to the development of hepatocellular carcinoma." -genetics_GWAS hsa-mir-27a "Carcinoma, Colon" 27751356 Association between microRNA-27a rs895819 polymorphism and risk of colorectal cancer: A meta-analysis. -genetics_GWAS hsa-mir-196a-2 Glioma 27796868 Effect of rs11614913 Polymorphism on Mature miR196a2 Expression and its Target Gene HOXC8 Expression in Human Glioma. -genetics_GWAS hsa-mir-34a Neuroblastoma 27805929 Genetic variant rs3750625 in the 3'UTR of ADRA2A affects stress-dependent acute pain severity after trauma and alters a microRNA-34a regulatory site. -genetics_GWAS hsa-mir-627 "Carcinoma, Breast" 27807724 rs15869 at miRNA binding site in BRCA2 is associated with breast cancer susceptibility. -genetics_GWAS hsa-mir-34b "Carcinoma, Hepatocellular" 27808368 Association between polymorphisms in the promoter region of pri-miR-34b/c and risk of hepatocellular carcinoma. -genetics_GWAS hsa-mir-34c "Carcinoma, Hepatocellular" 27808368 Association between polymorphisms in the promoter region of pri-miR-34b/c and risk of hepatocellular carcinoma. -genetics_GWAS hsa-mir-196a-2 Congenital Heart Diseases 27813602 "Association of miR-196a2, miR-27a, and miR-499 polymorphisms with isolated congenital heart disease in a Chinese population." -genetics_GWAS hsa-mir-27a Congenital Heart Diseases 27813602 "Association of miR-196a2, miR-27a, and miR-499 polymorphisms with isolated congenital heart disease in a Chinese population." -genetics_GWAS hsa-mir-499 Congenital Heart Diseases 27813602 "Association of miR-196a2, miR-27a, and miR-499 polymorphisms with isolated congenital heart disease in a Chinese population." -genetics_GWAS hsa-mir-125a "Carcinoma, Hepatocellular" 27814341 Association Between microRNA-125a rs12976445 C>T Polymorphism and 18F-Fluorodeoxyglucose (18FDG) Uptake: Clinical and Metabolic Response in Patients with Non-Small Cell Lung Cancer. -genetics_GWAS hsa-mir-146a Kaposi Sarcoma 27819716 Association of genetic variations in miR-146a rs2910164 and miR-149 rs11614913 with the development of classic Kaposi sarcoma. -genetics_GWAS hsa-mir-149 Kaposi Sarcoma 27819716 Association of genetic variations in miR-146a rs2910164 and miR-149 rs11614913 with the development of classic Kaposi sarcoma. -genetics_GWAS hsa-mir-146a "Carcinoma, Colon" 27824903 miR-146a Polymorphism (rs2910164) Predicts Colorectal Cancer Patients' Susceptibility to Liver Metastasis. -genetics_GWAS hsa-mir-205 "Carcinoma, Breast" 27885248 Rs3842530 Polymorphism in MicroRNA-205 Host Gene in Lung and Breast Cancer Patients. -genetics_GWAS hsa-mir-146a "Carcinoma, Hepatocellular" 27886162 miR-146a rs2910164 and hepatocellular carcinoma: a meta-analysis. -genetics_GWAS hsa-mir-34b "Leukemia, Lymphoblastic, Acute, Childhood" 27886674 Pri-miR-34b/c rs4938723 polymorphism is associated with the risk of childhood acute lymphoblastic leukemia. -genetics_GWAS hsa-mir-34c "Leukemia, Lymphoblastic, Acute, Childhood" 27886674 Pri-miR-34b/c rs4938723 polymorphism is associated with the risk of childhood acute lymphoblastic leukemia. -genetics_GWAS hsa-mir-27a Human Immunodeficiency Virus Infection 27919232 microRNA-27a rs895819 is associated with obesity in HIV infected preeclamptic Black South African women on HAART. -genetics_GWAS hsa-mir-34b "Carcinoma, Prostate" 27983526 Pri-miR-34b/c rs4938723 polymorphism increased the risk of prostate cancer. -genetics_GWAS hsa-mir-34c "Carcinoma, Prostate" 27983526 Pri-miR-34b/c rs4938723 polymorphism increased the risk of prostate cancer. -genetics_GWAS hsa-let-7 Liver Cirrhosis 27992614 A Single Nucleotide Polymorphism in the RASGRF2 Gene Is Associated with Alcoholic Liver Cirrhosis in Men. -genetics_GWAS hsa-mir-3131 "Carcinoma, Hepatocellular" 28034876 An indel polymorphism within pre-miR3131 confers risk for hepatocellular carcinoma. -genetics_GWAS hsa-mir-1269a "Carcinoma, Hepatocellular" 28081866 A single nucleotide variant in microRNA-1269a promotes the occurrence and process of hepatocellular carcinoma by targeting to oncogenes SPATS2L and LRP6. -genetics_GWAS hsa-mir-122 Chronic Hepatitis C 28082397 Differential hepatitis C virus RNA target site selection and host factor activities of naturally occurring miR-122 3? variants. -genetics_GWAS hsa-mir-146a Rheumatoid Arthritis 28083614 Significance of Polymorphism and Expression of miR-146a and NFkB1 Genetic Variants in Patients with Rheumatoid Arthritis. -genetics_GWAS hsa-mir-146a "Diabetes Mellitus, Type 2" 28101643 Polymorphisms in genes encoding miR-155 and miR-146a are associated with protection to type 1 diabetes mellitus. -genetics_GWAS hsa-mir-155 "Diabetes Mellitus, Type 2" 28101643 Polymorphisms in genes encoding miR-155 and miR-146a are associated with protection to type 1 diabetes mellitus. -genetics_GWAS hsa-mir-34b Retinoblastoma 28106538 A polymorphism in mir-34b/c as a potential biomarker for early onset of hereditary retinoblastoma. -genetics_GWAS hsa-mir-34c Retinoblastoma 28106538 A polymorphism in mir-34b/c as a potential biomarker for early onset of hereditary retinoblastoma. -genetics_GWAS hsa-mir-1203 "Stroke, Ischemic" 28171870 Methylene Tetrahydrofolate Reductase (MTHFR) rs868014 Polymorphism Regulated by miR-1203 Associates with Risk and Short Term Outcome of Ischemic Stroke. -genetics_GWAS hsa-mir-149 Allergic Rhinitis 28181414 A functional variant of miRNA-149 confers risk for allergic rhinitis and comorbid asthma in Chinese children. -genetics_GWAS hsa-mir-146a "Carcinoma, Hepatocellular" 28188097 "Our findings supported the proposition that the polymorphisms of miR-146a rs2910164, miR-196a2 rs11614913, and miR-196a2 rs11614913 may contribute to the susceptibility of HCC" -genetics_GWAS hsa-mir-196a "Carcinoma, Hepatocellular" 28188097 "Our findings supported the proposition that the polymorphisms of miR-146a rs2910164, miR-196a2 rs11614913, and miR-196a2 rs11614913 may contribute to the susceptibility of HCC" -genetics_GWAS hsa-mir-27b "Carcinoma, Gastric" 28214904 rs10719 Polymorphism Located within DROSHA 3'-Untranslated Region is Responsible for Development of Primary Hypertension by Disrupting Binding with microRNA-27b. -genetics_GWAS hsa-mir-199a "Stroke, Ischemic" 28234972 the +936C/T variants significantly increased the risk of poorer stroke outcome by affecting the bindings of miR-199a and miR-199b to VEGF mRNA at the rs30250340 polymorphic site -genetics_GWAS hsa-mir-199b "Stroke, Ischemic" 28234972 the +936C/T variants significantly increased the risk of poorer stroke outcome by affecting the bindings of miR-199a and miR-199b to VEGF mRNA at the rs30250340 polymorphic site -genetics_GWAS hsa-mir-126 Endometriosis 28277133 mir-126 rs4636297 and TGF¦ÂRI rs334348 functional gene variants are associated with susceptibility to endometriosis and its severity. -genetics_GWAS hsa-mir-218 "Carcinoma, Gastric" 28298809 "Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis." -genetics_GWAS hsa-mir-219 "Carcinoma, Gastric" 28298809 "Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis." -genetics_GWAS hsa-mir-34b "Carcinoma, Gastric" 28298809 "Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis." -genetics_GWAS hsa-mir-34c "Carcinoma, Gastric" 28298809 "Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis." -genetics_GWAS hsa-mir-938 "Carcinoma, Gastric" 28298809 "Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis." -genetics_GWAS hsa-mir-196a "Colitis, Ulcerative" 28301487 Association of miR-196a-2 and miR-499 variants with ulcerative colitis and their correlation with expression of respective miRNAs. -genetics_GWAS hsa-mir-499 "Colitis, Ulcerative" 28301487 Association of miR-196a-2 and miR-499 variants with ulcerative colitis and their correlation with expression of respective miRNAs. -genetics_GWAS hsa-let-7 Macular Degeneration 28343170 "miRNAs, single nucleotide polymorphisms (SNPs) and age-related macular degeneration (AMD)." -genetics_GWAS hsa-let-7a Macular Degeneration 28343170 "miRNAs, single nucleotide polymorphisms (SNPs) and age-related macular degeneration (AMD)." -genetics_GWAS hsa-let-7b Macular Degeneration 28343170 "miRNAs, single nucleotide polymorphisms (SNPs) and age-related macular degeneration (AMD)." -genetics_GWAS hsa-let-7d Macular Degeneration 28343170 "miRNAs, single nucleotide polymorphisms (SNPs) and age-related macular degeneration (AMD)." -genetics_GWAS hsa-mir-146a Macular Degeneration 28343170 "miRNAs, single nucleotide polymorphisms (SNPs) and age-related macular degeneration (AMD)." -genetics_GWAS hsa-mir-155 Macular Degeneration 28343170 "miRNAs, single nucleotide polymorphisms (SNPs) and age-related macular degeneration (AMD)." -genetics_GWAS hsa-mir-101 "Carcinoma, Hepatocellular" 28366737 miRNA-101-1 and miRNA-221 expressions and their polymorphisms as biomarkers for early diagnosis of hepatocellular carcinoma. -genetics_GWAS hsa-mir-221 "Carcinoma, Hepatocellular" 28366737 miRNA-101-1 and miRNA-221 expressions and their polymorphisms as biomarkers for early diagnosis of hepatocellular carcinoma. -genetics_GWAS hsa-mir-4293 "Carcinoma, Lung, Non-Small-Cell" 28410417 Genetic variant of miR-4293 rs12220909 is associated with susceptibility to non-small cell lung cancer in a Chinese Han population. -genetics_GWAS hsa-mir-423 Neoplasms [unspecific] 28430524 miRNA-Related Polymorphisms in miR-423 (rs6505162) and PEX6 (rs1129186) and Risk of Esophageal Squamous Cell Carcinoma in an Iranian Cohort. -genetics_GWAS hsa-mir-122 "Carcinoma, Hepatocellular" 28512857 Interest of variations in microRNA-152 and -122 in a series of hepatocellular carcinomas related to hepatitis C virus infection. -genetics_GWAS hsa-mir-149 Gastric Neoplasms 28523307 miR-149 rs2292832 C>T polymorphism and risk of gastric cancer. -genetics_GWAS hsa-mir-608 "Carcinoma, Colon" 28653886 The miR-608 rs4919510 polymorphism may modify cancer susceptibility based on type. -genetics_GWAS hsa-mir-146a Melanoma 28654546 Sex-specific effect of RNASEL rs486907 and miR-146a rs2910164 polymorphisms' interaction as a susceptibility factor for melanoma skin cancer. -genetics_GWAS hsa-mir-146a Atherosclerosis 28674224 Association of NFKB1A and microRNAs variations and the susceptibility to atherosclerosis. -genetics_GWAS hsa-mir-181a Neuroinflammation 28769921 MicroRNA-181 Variants Regulate T Cell Phenotype in the Context of Autoimmune Neuroinflammation -genetics_GWAS hsa-mir-181b Neuroinflammation 28769921 MicroRNA-181 Variants Regulate T Cell Phenotype in the Context of Autoimmune Neuroinflammation. -genetics_GWAS hsa-mir-146a Thyroid Neoplasms 28899898 The rs2910164 variant in MIR146A is significantly associated with DTC -genetics_GWAS hsa-mir-149 "Squamous Cell Carcinoma, Oral" 29103762 miRNA genetic variants: As potential diagnostic biomarkers for oral cancer. -genetics_GWAS hsa-mir-146a Lung Neoplasms 29127520 MiR-146a rs2910164 polymorphism might be associated with the susceptibility to lung cancer and nasopharyngeal carcinoma -genetics_GWAS hsa-mir-146a Nasopharyngeal Neoplasms 29127520 MiR-146a rs2910164 polymorphism might be associated with the susceptibility to lung cancer and nasopharyngeal carcinoma -genetics_GWAS hsa-mir-122 Stroke 29145255 Functional polymorphism rs3783553 in the 3'-untranslated region of IL-1A increased the risk of ischemic stroke -genetics_GWAS hsa-mir-196a Crohn Disease 29152405 "Association of miR-146 rs2910164, miR-196a rs11614913, miR-221 rs113054794 and miR-224 rs188519172 polymorphisms with anti-TNF treatment response in a Greek population with Crohn's disease" -genetics_GWAS hsa-let-7i "Squamous Cell Carcinoma, Cerevial" 29154871 Association between genetic polymorphisms in the promoters of let-7 and risk of cervical squamous cell carcinoma -genetics_GWAS hsa-mir-146a Creutzfeldt-Jakob Disease 29216791 The associations of two SNPs in miRNA-146a and one SNP in ZBTB38-RASA2 with the disease susceptibility and the clinical features of the Chinese patients of sCJD and FFI. -genetics_GWAS hsa-mir-126 Myocardial Infarction 29304813 The association between pre-miR-27a rs895819 polymorphism and myocardial infarction risk in a Chinese Han population -genetics_GWAS hsa-mir-98 Osteoporosis 29307778 Computational and functional characterization of four SNPs in the SOST locus associated with osteoporosis -genetics_GWAS hsa-mir-423 Colorectal Carcinoma 29419695 Association of microRNA-423 rs6505162 C>A polymorphism with susceptibility and metastasis of colorectal carcinoma. -genetics_GWAS hsa-mir-146a Bladder Neoplasms 29491365 "miR-146a rs2910164 polymorphism is a risk factor for urological neoplasms, particularly for bladder cancer" -genetics_GWAS hsa-mir-6720 Lymphedema 29511529 "rs121909106 and rs121909107 were predicted to have the most harmful effects, while hsa-miR-6886-5p, hsa-miR-6886-5p and hsa-miR-6720-3p were predicted to be the most important miRNAs affected" -genetics_GWAS hsa-mir-6886 Lymphedema 29511529 "rs121909106 and rs121909107 were predicted to have the most harmful effects, while hsa-miR-6886-5p, hsa-miR-6886-5p and hsa-miR-6720-3p were predicted to be the most important miRNAs affected" -genetics_GWAS hsa-mir-146a Breast Neoplasms 29521182 "Effects of miR-27a, miR-196a2 and miR-146a polymorphisms on the risk of breast cancer" -genetics_GWAS hsa-mir-196a-2 Breast Neoplasms 29521182 "Effects of miR-27a, miR-196a2 and miR-148a polymorphisms on the risk of breast cancer" -genetics_GWAS hsa-mir-27a Breast Neoplasms 29521182 "Effects of miR-27a, miR-196a2 and miR-147a polymorphisms on the risk of breast cancer" -genetics_GWAS hsa-mir-556 "Carcinoma, Renal Cell, Clear-Cell" 29569387 A novel functional polymorphism of GSTM3 reduces clear cell renal cell carcinoma risk through enhancing its expression by interfering miR-556 binding. -genetics_GWAS hsa-mir-146a Psoriasis 29587639 "A single nucleotide polymorphism in the miR-146a gene (rs2910164), aberrantly alters its gene expression and linked with the pathogenesis of several disorders, including psoriasis and PsA" -genetics_GWAS hsa-mir-146a Psoriatic Arthritis 29587639 "A single nucleotide polymorphism in the miR-146a gene (rs2910164), aberrantly alters its gene expression and linked with the pathogenesis of several disorders, including psoriasis and PsA" -genetics_GWAS hsa-mir-1302 Infertility 29627965 Association of T/A polymorphism in miR-1302 binding site in CGA gene with male infertility in Isfahan population. -genetics_GWAS hsa-mir-146a Polycystic Ovarian Syndrome 29637801 "women with miR-146a variation are at a higher risk for developing PCOS, which can be due to up-regulation of miR-146a" -genetics_GWAS hsa-mir-196a-2 "Squamous Cell Carcinoma, Head and Neck" 29705927 "Single nucleotide polymorphism rs11614913 associated with CC genotype in miR-196a2 is overrepresented in laryngeal squamous cell carcinoma, but not salivary gland tumors in Polish population." -genetics_GWAS hsa-mir-146a Colorectal Carcinoma 29715515 Hsa-mir-149C/T rs2292832 and hsa-mir-146a G/C rs2910164 may influence CRC risk in an ethnicity-dependent manner by interfering with CRC progression parameters in Tunisian cohort -genetics_GWAS hsa-mir-149 Colorectal Carcinoma 29715515 Hsa-mir-149C/T rs2292832 and hsa-mir-146a G/C rs2910164 may influence CRC risk in an ethnicity-dependent manner by interfering with CRC progression parameters in Tunisian cohort -genetics_GWAS hsa-mir-149 Charcot-Marie-Tooth Disease Type 1A 29729827 Association of miR-149 polymorphism with onset age and severity in Charcot-Marie-Tooth disease type 1A. -genetics_GWAS hsa-mir-218 Neuroblastoma 29858046 the miR-34b/c rs4938723?T > C and miR-218 rs11134527 A > G polymorphisms displayed a protective role from neuroblastoma -genetics_GWAS hsa-mir-34b Neuroblastoma 29858046 the miR-34b/c rs4938723?T > C and miR-218 rs11134527 A > G polymorphisms displayed a protective role from neuroblastoma -genetics_GWAS hsa-mir-34c Neuroblastoma 29858046 the miR-34b/c rs4938723?T > C and miR-218 rs11134527 A > G polymorphisms displayed a protective role from neuroblastoma -genetics_GWAS hsa-mir-124-1 Gastric Neoplasms 29938592 Influence of single nucleotide polymorphisms in pri-miR-124-1 and STAT3 genes on gastric cancer susceptibility. -genetics_GWAS hsa-mir-499 "Carcinoma, Hepatocellular" 29946268 "miR-499 rs3746444 is associated with susceptibility of cervical squamous cell carcinoma, lung cancer, prostate cancer, and hepatocellular carcinoma" -genetics_GWAS hsa-mir-499 Lung Neoplasms 29946268 "miR-499 rs3746444 is associated with susceptibility of cervical squamous cell carcinoma, lung cancer, prostate cancer, and hepatocellular carcinoma" -genetics_GWAS hsa-mir-499 Prostate Neoplasms 29946268 "miR-499 rs3746444 is associated with susceptibility of cervical squamous cell carcinoma, lung cancer, prostate cancer, and hepatocellular carcinoma" -genetics_GWAS hsa-mir-499 "Squamous Cell Carcinoma, Cerevial" 29946268 "miR-499 rs3746444 is associated with susceptibility of cervical squamous cell carcinoma, lung cancer, prostate cancer, and hepatocellular carcinoma" -genetics_GWAS hsa-mir-499 "Carcinoma, Hepatocellular" 29970712 MiR-499 rs3746444 polymorphism and hepatocellular carcinoma risk: A meta-analysis. -genetics_GWAS hsa-mir-146a Prostate Neoplasms 30001553 "Polymorphisms of miR-196a2 rs11614913, miR-146a rs2910164, and miR-499 rs3746444 may contribute to the risk for developing prostate cancer in Asian descendants" -genetics_GWAS hsa-mir-196a Prostate Neoplasms 30001553 "Polymorphisms of miR-196a2 rs11614913, miR-146a rs2910164, and miR-499 rs3746444 may contribute to the risk for developing prostate cancer in Asian descendants" -genetics_GWAS hsa-mir-499 Prostate Neoplasms 30001553 "Polymorphisms of miR-196a2 rs11614913, miR-146a rs2910164, and miR-499 rs3746444 may contribute to the risk for developing prostate cancer in Asian descendants" -genetics_GWAS hsa-mir-122 Hepatitis C Virus Infection 30053137 "miR-122, small RNA annealing and sequence mutations alter the predicted structure of the Hepatitis C virus 5' UTR RNA to stabilize and promote viral RNA accumulation." -genetics_GWAS hsa-mir-146a Lung Neoplasms 30069329 "We found that an allele carriers of miR-146a rs2910164 (P=0.022, OR=1.315) and C allele carriers of miR-149 rs71428439 (P=0.042, OR=1.372) performance a high risk of lung cancer" -genetics_GWAS hsa-mir-149 Lung Neoplasms 30069329 "We found that an allele carriers of miR-146a rs2910164 (P=0.022, OR=1.315) and C allele carriers of miR-149 rs71428439 (P=0.042, OR=1.372) performance a high risk of lung cancer" -genetics_GWAS hsa-mir-499 Congenital Heart Diseases 30084801 Association of a MiR-499 SNP and risk of congenital heart disease in a Chinese population. -genetics_GWAS hsa-mir-499 Cardiovascular Diseases [unspecific] 30102014 A polymorphism rs3746444 within the pre-miR-499 alters the maturation of miR-499-5p and its antiapoptotic function. -genetics_GWAS hsa-mir-218 "Squamous Cell Carcinoma, Esophageal" 30120974 Association between miR-218 rs11134527 polymorphism and risk of selected types of cancer in Asian population: An updated meta-analysis of case-control studies. -genetics_GWAS hsa-mir-125a "Carcinoma, Breast" 30135399 "Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population." -genetics_GWAS hsa-mir-146a "Carcinoma, Breast" 30135399 "Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population." -genetics_GWAS hsa-mir-182 "Carcinoma, Breast" 30135399 "Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population." -genetics_GWAS hsa-mir-499 "Carcinoma, Breast" 30135399 "Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population." -genetics_GWAS hsa-mir-605 "Carcinoma, Breast" 30135399 "Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population." -genetics_GWAS hsa-mir-3161 Glaucoma 30148417 "MicroRNA-related polymorphisms in pseudoexfoliation syndrome, pseudoexfoliative glaucoma, and primary open-angle glaucoma." -genetics_GWAS hsa-mir-21 Atherosclerosis 30205366 rs145204276 was associated with the risk of atherosclerosis by affecting the proliferation and apoptosis of endothelial cells via regulating the GAS5/miR-21/PDCD4 signaling pathway -genetics_GWAS hsa-mir-499 "Stroke, Ischemic" 30229913 hsa-mir-499 rs3746444 A/G polymorphism may be associated with a significantly increased risk of IS in an Iranian population -genetics_GWAS hsa-mir-34a Gastric Neoplasms 30242897 Minor allele of rs1057317 polymorphism in TLR4 is associated with increased risk of Helicobacter pylori -induced gastric cancer. -genetics_GWAS hsa-mir-146a "Stroke, Ischemic" 30254431 the GG genotype of miR-146a (rs2910164) and CC genotype of miR-149 (rs2292832) may confer increased susceptibility to IS -genetics_GWAS hsa-mir-149 "Stroke, Ischemic" 30254431 the GG genotype of miR-146a (rs2910164) and CC genotype of miR-149 (rs2292832) may confer increased susceptibility to IS -genetics_GWAS hsa-mir-300 Lung Neoplasms 30271206 miR-300 rs12894467 polymorphism may be associated with susceptibility to primary lung cancer in the Chinese Han population. -genetics_GWAS hsa-mir-149 Gastric Neoplasms 30274913 Association Between miR-149 Gene rs2292832 Polymorphism and Risk of Gastric Cancer: A Case-control Study. -genetics_GWAS hsa-mir-146a "Colitis, Ulcerative" 30278502 Association of miRNA-146a rs2910164 and miRNA-196 rs11614913 polymorphisms in patients with ulcerative colitis: A meta-analysis and review. -genetics_GWAS hsa-mir-196a "Colitis, Ulcerative" 30278502 Association of miRNA-146a rs2910164 and miRNA-196 rs11614913 polymorphisms in patients with ulcerative colitis: A meta-analysis and review. -genetics_GWAS hsa-mir-423 Coronary Artery Disease 30289085 Potential impact of microRNA-423 gene variability in coronary artery disease. -genetics_GWAS hsa-mir-125a "Carcinoma, Lung" 30302847 Regulation of miR-125a expression by rs12976445 single-nucleotide polymorphism?is associated with radiotherapy-induced pneumonitis in lung carcinoma patients. -genetics_GWAS hsa-mir-589 Cataract 30315181 luciferase reporter gene expression can be down regulated by hsa-miR-589-5p in cells transfected with rs2229090 C allele compared to G allele -genetics_GWAS hsa-mir-579 Anxiety Disorders 30341278 A functional genetic variation of SLC6A2 repressor hsa-miR-579-3p upregulates sympathetic noradrenergic processes of fear and anxiety. -genetics_GWAS hsa-mir-21 Inflammation 30375257 Cigarette smoking affects microRNAs and inflammatory biomarkers in healthy individuals and an association to single nucleotide polymorphisms is indicated. -genetics_knock down_promote hsa-mir-15a Leukemia 12434020 deletion or downregulation -genetics_knock down_promote hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 12434020 deletion or downregulation -genetics_knock down_promote hsa-mir-16-1 Leukemia 12434020 deletion or downregulation -genetics_knock down_promote hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 12434020 deletion or downregulation -genetics_knock down_promote hsa-mir-125b-1 Breast Neoplasms 14973191 deletion -genetics_knock down_promote hsa-mir-125b-1 Lung Neoplasms 14973191 deletion -genetics_knock down_promote hsa-mir-125b-1 Ovarian Neoplasms 14973191 deletion -genetics_knock down_promote hsa-mir-125b-1 Urinary Bladder Cancer 14973191 deletion -genetics_knock down_promote hsa-mir-17 "Carcinoma, Hepatocellular" 15944709 loss of heterozygosity of this cluster -genetics_knock down_promote hsa-mir-18a "Carcinoma, Hepatocellular" 15944709 loss of heterozygosity of this cluster -genetics_knock down_promote hsa-mir-19a "Carcinoma, Hepatocellular" 15944709 loss of heterozygosity of this cluster -genetics_knock down_promote hsa-mir-19b-1 "Carcinoma, Hepatocellular" 15944709 loss of heterozygosity of this cluster -genetics_knock down_promote hsa-mir-20a "Carcinoma, Hepatocellular" 15944709 loss of heterozygosity of this cluster -genetics_knock down_promote hsa-mir-125b-1 "Leukemia-Lymphoma, Precursor B-Cell Lymphoblastic" 16151463 an insertion of pre-miRNA into the immunoglobulin heavy-chain locus -genetics_knock down_promote hsa-mir-15a Leukemia 16166262 the deletion or downregulation of mir-15a results in increased expression of BCL2. -genetics_knock down_promote hsa-mir-15a Lymphoma 16166262 the deletion or downregulation of mir-15a results in increased expression of BCL2. -genetics_knock down_promote hsa-mir-16-1 Leukemia 16166262 the deletion or downregulation of mir-15a results in increased expression of BCL2. -genetics_knock down_promote hsa-mir-16-1 Lymphoma 16166262 the deletion or downregulation of mir-15a results in increased expression of BCL2. -genetics_knock down_promote hsa-mir-125b-1 "Leukemia, B-Cell" 16885332 "In a precursor B-cell acute lymphoblastic leukemia, an insertion of miR-125b-1 into a rearranged immunoglobulin heavy chain locus was described." -genetics_knock down_promote hsa-mir-142 "Leukemia, B-Cell" 16885332 It was shown later that miR-142 is located at the chromosome 17 breakpoint and that c-Myc was rearranged under the control of the promoter of miR-142 with consequent overexpression. -genetics_knock down_promote hsa-mir-15a "Leukemia, B-Cell" 16885332 Deleted and down-regulated in the majority of B-CLLs -genetics_knock down_promote hsa-mir-15a Pituitary Neoplasms 16885332 a type of benign tumors displaying deletions at 13q14.3 and reduced expression of miR-16-1 and miR-15a -genetics_knock down_promote hsa-mir-16-1 "Leukemia, B-Cell" 16885332 Deleted and down-regulated in the majority of B-CLLs -genetics_knock down_promote hsa-mir-16-1 Pituitary Neoplasms 16885332 a type of benign tumors displaying deletions at 13q14.3 and reduced expression of miR-16-1 and miR-15a -genetics_knock down_promote hsa-mir-17 Breast Neoplasms 16940181 "The genomic location of Mir-17-5p also undergoesloss of heterozygosity in different types of cancer, including breast cancer." -genetics_knock down_promote hsa-mir-92a-1 Hematologic Neoplasms 17011485 The miR-17-92 cluster is amplified in hematopoietic malignancies. -genetics_knock down_promote hsa-mir-15a Breast Neoplasms 17012848 "Later on, deletion of mir-16-1 and mir-15a deletion were also identified in epithelial tumors, such as pituitary adenomas, ovarian and breast cancer." -genetics_knock down_promote hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 17012848 "It was found that mir-16-1 and mir-15a at 13q14 are deleted in more than 50% patients, with concurrent reduced expression in ~65% patients. Further studies demonstrated that these two miRNAs suppress BCL2 expression and may serve as tumor suppressor genes in this disease." -genetics_knock down_promote hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 17012848 "It was found that mir-16-1 and mir-15a at 13q14 are deleted in more than 50% patients, with concurrent reduced expression in ~65% patients. Further studies demonstrated that these two miRNAs suppress BCL2 expression and may serve as tumor suppressor genes in this disease." -genetics_knock down_promote hsa-mir-16-1 Ovarian Neoplasms 17012848 "Later on, deletion of mir-16-1 and mir-15a deletion were also identified in epithelial tumors, such as pituitary adenomas, ovarian and breast cancer." -genetics_knock down_promote hsa-mir-16-1 Pituitary Neoplasms 17012848 "Later on, deletion of mir-16-1 and mir-15a deletion were also identified in epithelial tumors, such as pituitary adenomas, ovarian and breast cancer." -genetics_knock down_promote hsa-mir-125b-1 "Leukemia, B-Cell" 17028302 "It is of note that insertion of miR-125b-1 into a rearranged immunoglobulin heavy chain gene locus was recently reported in a patient with precursor B-cell acute lymphoblastic leukemia, though the expression miR-125b-1 was not investigated." -genetics_knock down_promote hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 17028302 "Detailed analyses of deletion and expression status revealed these two miRNAs to be located within a 30 kb minimally deleted region in chronic lymphocytic leukemia (CLL) patients, both of which were deleted or downregulated in most CLL cases, suggesting that miR-15a and miR-16-1 may function as tumor suppressor genes." -genetics_knock down_promote hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 17028302 "Detailed analyses of deletion and expression status revealed these two miRNAs to be located within a 30 kb minimally deleted region in chronic lymphocytic leukemia (CLL) patients, both of which were deleted or downregulated in most CLL cases, suggesting that miR-15a and miR-16-1 may function as tumor suppressor genes." -genetics_knock down_promote hsa-mir-199a-1 "Carcinoma, Hepatocellular" 17188425 "This region encodes miRNA-199a-1 (19p13.2), whose expression levels are lower in HCC compared to nontumor liver [59] and is deleted in several other tumor types." -genetics_knock down_promote hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 17234972 "After years of futile attemptsto identify the gene(s) in the deleted 13q14 region that participatein the pathogenesis of chronic lymphocytic leukemia, Calin etal discovered that miR-15 and miR-16 are located within thissequence and that both are downregulated in 68% of cases." -genetics_knock down_promote hsa-mir-15b "Leukemia, Lymphocytic, Chronic, B-Cell" 17234972 "After years of futile attemptsto identify the gene(s) in the deleted 13q14 region that participatein the pathogenesis of chronic lymphocytic leukemia, Calin etal discovered that miR-15 and miR-16 are located within thissequence and that both are downregulated in 68% of cases." -genetics_knock down_promote hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 17234972 "After years of futile attemptsto identify the gene(s) in the deleted 13q14 region that participatein the pathogenesis of chronic lymphocytic leukemia, Calin etal discovered that miR-15 and miR-16 are located within thissequence and that both are downregulated in 68% of cases." -genetics_knock down_promote hsa-mir-16-2 "Leukemia, Lymphocytic, Chronic, B-Cell" 17234972 "After years of futile attemptsto identify the gene(s) in the deleted 13q14 region that participatein the pathogenesis of chronic lymphocytic leukemia, Calin etal discovered that miR-15 and miR-16 are located within thissequence and that both are downregulated in 68% of cases." -genetics_knock down_promote hsa-mir-181b-2 Urinary Bladder Cancer 17470785 "mir-181b-2 and mir-199b are 3.3 Mb from the peak of the colon Scc2 locus on Chr 2; homologous human miRNAs are located inside a cancer-associated genomic region, which is a region commonly deleted in bladder cancer." -genetics_knock down_promote hsa-mir-199b Urinary Bladder Cancer 17470785 "mir-181b-2 and mir-199b are 3.3 Mb from the peak of the colon Scc2 locus on Chr 2; homologous human miRNAs are located inside a cancer-associated genomic region, which is a region commonly deleted in bladder cancer." -genetics_knock down_promote hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 17531469 "The loss-of-function of miR-15a and miR-16-1 in CLL, and perhaps other cancers as well, may contribute to malignant transformation by upregulating Bcl2 thereby preventing apoptosis." -genetics_knock down_promote hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 17531469 "the loss-of-function of miR-15a and miR-16-1 in CLL, and perhaps other cancers as well, may contribute to malignant transformation by upregulating Bcl2 thereby preventing apoptosis." -genetics_knock down_promote hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 17940623 "The common loss of miR-15a and miR-16-1 in CLL, as well as the loss of 13q14 in mantle cell lymphoma (50 percent of cases), multiple myeloma (16 to 40 percent) and prostate cancer (60 percent), strongly suggests that these two miRNAs act as tumor suppressor genes. While their full target complement is unknown, they appear to mediate their effects largely by down-regulating the anti-apoptotic protein BCL2. This protein is often found expressed at high levels in CLL and is thought to be important for the survival of the malignant cells." -genetics_knock down_promote hsa-mir-15a "Lymphoma, Mantle-Cell" 17940623 "The common loss of miR-15a and miR-16-1 in CLL, as well as the loss of 13q14 in mantle cell lymphoma (50 percent of cases), multiple myeloma (16 to 40 percent) and prostate cancer (60 percent), strongly suggests that these two miRNAs act as tumor suppressor genes. While their full target complement is unknown, they appear to mediate their effects largely by down-regulating the anti-apoptotic protein BCL2. This protein is often found expressed at high levels in CLL and is thought to be important for the survival of the malignant cells." -genetics_knock down_promote hsa-mir-15a Multiple Myeloma 17940623 "The common loss of miR-15a and miR-16-1 in CLL, as well as the loss of 13q14 in mantle cell lymphoma (50 percent of cases), multiple myeloma (16 to 40 percent) and prostate cancer (60 percent), strongly suggests that these two miRNAs act as tumor suppressor genes. While their full target complement is unknown, they appear to mediate their effects largely by down-regulating the anti-apoptotic protein BCL2. This protein is often found expressed at high levels in CLL and is thought to be important for the survival of the malignant cells." -genetics_knock down_promote hsa-mir-15a Prostate Neoplasms 17940623 "The common loss of miR-15a and miR-16-1 in CLL, as well as the loss of 13q14 in mantle cell lymphoma (50 percent of cases), multiple myeloma (16 to 40 percent) and prostate cancer (60 percent), strongly suggests that these two miRNAs act as tumor suppressor genes. While their full target complement is unknown, they appear to mediate their effects largely by down-regulating the anti-apoptotic protein BCL2. This protein is often found expressed at high levels in CLL and is thought to be important for the survival of the malignant cells." -genetics_knock down_promote hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 17940623 "The common loss of miR-15a and miR-16-1 in CLL, as well as the loss of 13q14 in mantle cell lymphoma (50 percent of cases), multiple myeloma (16 to 40 percent) and prostate cancer (60 percent), strongly suggests that these two miRNAs act as tumor suppressor genes. While their full target complement is unknown, they appear to mediate their effects largely by down-regulating the anti-apoptotic protein BCL2. This protein is often found expressed at high levels in CLL and is thought to be important for the survival of the malignant cells." -genetics_knock down_promote hsa-mir-16-1 "Lymphoma, Mantle-Cell" 17940623 "The common loss of miR-15a and miR-16-1 in CLL, as well as the loss of 13q14 in mantle cell lymphoma (50 percent of cases), multiple myeloma (16 to 40 percent) and prostate cancer (60 percent), strongly suggests that these two miRNAs act as tumor suppressor genes. While their full target complement is unknown, they appear to mediate their effects largely by down-regulating the anti-apoptotic protein BCL2. This protein is often found expressed at high levels in CLL and is thought to be important for the survival of the malignant cells." -genetics_knock down_promote hsa-mir-16-1 Multiple Myeloma 17940623 "The common loss of miR-15a and miR-16-1 in CLL, as well as the loss of 13q14 in mantle cell lymphoma (50 percent of cases), multiple myeloma (16 to 40 percent) and prostate cancer (60 percent), strongly suggests that these two miRNAs act as tumor suppressor genes. While their full target complement is unknown, they appear to mediate their effects largely by down-regulating the anti-apoptotic protein BCL2. This protein is often found expressed at high levels in CLL and is thought to be important for the survival of the malignant cells." -genetics_knock down_promote hsa-mir-16-1 Prostate Neoplasms 17940623 "The common loss of miR-15a and miR-16-1 in CLL, as well as the loss of 13q14 in mantle cell lymphoma (50 percent of cases), multiple myeloma (16 to 40 percent) and prostate cancer (60 percent), strongly suggests that these two miRNAs act as tumor suppressor genes. While their full target complement is unknown, they appear to mediate their effects largely by down-regulating the anti-apoptotic protein BCL2. This protein is often found expressed at high levels in CLL and is thought to be important for the survival of the malignant cells." -genetics_knock down_promote hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 17965831 "miR-15a and miR-16 are often deleted from chromosome 13q14.2 in patients with B cell CLL, suggesting that these miRNAs may be involved in tumour suppression. Additionally, introduction of exogenous miR-16 into a malignant B-1 cell line resulted in increased apoptosis." -genetics_knock down_promote hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 17965831 "miR-15a and miR-16 are often deleted from chromosome 13q14.2 in patients with B cell CLL, suggesting that these miRNAs may be involved in tumour suppression. Additionally, introduction of exogenous miR-16 into a malignant B-1 cell line resulted in increased apoptosis." -genetics_knock down_promote hsa-mir-16-2 "Leukemia, Lymphocytic, Chronic, B-Cell" 17965831 "miR-15a and miR-16 are often deleted from chromosome 13q14.2 in patients with B cell CLL, suggesting that these miRNAs may be involved in tumour suppression. Additionally, introduction of exogenous miR-16 into a malignant B-1 cell line resulted in increased apoptosis." -genetics_knock down_promote hsa-mir-29a Alzheimer Disease 18434550 loss -genetics_knock down_promote hsa-mir-29b-1 Alzheimer Disease 18434550 loss -genetics_knock down_promote hsa-mir-1-1 "Carcinoma, Hepatocellular" 18593903 miR-1: silenced -genetics_knock down_promote hsa-mir-1-2 "Carcinoma, Hepatocellular" 18593903 miR-1: silenced -genetics_knock down_promote hsa-mir-34a Neoplasms [unspecific] 18834855 miR-34a: reduced or lost -genetics_knock down_promote hsa-mir-101-1 Neoplasms [unspecific] 19008416 miR-101: Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer -genetics_knock down_promote hsa-mir-101-2 Neoplasms [unspecific] 19008416 miR-101: Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer -genetics_knock down_promote hsa-mir-31 Neoplasms [unspecific] 20179198 miR-31 is associated with defects in the p53 pathway and functions in serous ovarian cancer and other cancers -genetics_knock down_promote hsa-mir-31 Ovarian Neoplasms 20179198 miR-31 is associated with defects in the p53 pathway and functions in serous ovarian cancer and other cancers -genetics_knock down_promote hsa-mir-143 Neoplasms [unspecific] 20439436 miR-143:We correctly identified hsa-miR-17/92 family as amplified and the hsa-miR-143/145 cluster as deleted -genetics_knock down_promote hsa-mir-145 Neoplasms [unspecific] 20439436 miR-145:We correctly identified hsa-miR-17/92 family as amplified and the hsa-miR-143/145 cluster as deleted -genetics_knock down_promote hsa-mir-31 Mesothelioma 20463022 miR-31:Pro-tumorigenic effects of miR-31 loss in mesothelioma -genetics_knock down_promote hsa-mir-301a Lung Neoplasms 20470754 "miR-301:blocking of miR-301 in A549 cells leads to a decrease in the expression of the host gene, ska2" -genetics_knock down_promote hsa-mir-29a "Leukemia, Myeloid, Acute" 20628397 miR-29a:The tumour-suppressive miR-29a/b1 cluster is regulated by CEBPA and blocked in human AML -genetics_knock down_promote hsa-mir-29b-1 "Leukemia, Myeloid, Acute" 20628397 miR-29b1:The tumour-suppressive miR-29a/b1 cluster is regulated by CEBPA and blocked in human AML -genetics_knock down_promote hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 21156224 often absent -genetics_knock down_promote hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 21156224 often absent -genetics_knock down_promote hsa-mir-107 Urinary Bladder Cancer 21388952 Specific deletion of p53 in urothelial cells is associated with specific overexpression of miR-18a and miR-19a and down-regulation of miR-107. -genetics_knock down_promote hsa-mir-486 Gastric Neoplasms 21415212 Genomic Loss of miR-486 Regulates Tumor Progression and the OLFM4 Anti-apoptotic Factor in Gastric Cancer. -genetics_knock down_promote hsa-mir-15a Prostate Neoplasms 21472816 The miR-15a-miR-16-1 locus is homozygously deleted in a subset of prostate cancers. -genetics_knock down_promote hsa-mir-16-1 Prostate Neoplasms 21472816 The miR-15a-miR-16-1 locus is homozygously deleted in a subset of prostate cancers. -genetics_knock down_promote hsa-mir-218-1 Urinary Bladder Cancer 21519788 miR-218 on the genomic loss region of chromosome 4p15.31 functions as a tumor suppressor in bladder cancer. -genetics_knock down_promote hsa-mir-218-2 Urinary Bladder Cancer 21519788 miR-218 on the genomic loss region of chromosome 4p15.31 functions as a tumor suppressor in bladder cancer. -genetics_knock down_promote hsa-mir-1-1 Myotonic Muscular Dystrophy 21685920 "As a consequence of miR-1 loss, expression of GJA1 (connexin 43) and CACNA1C (Cav1.2), which are targets of miR-1, is increased in both DM1- and DM2-affected hearts." -genetics_knock down_promote hsa-mir-1-2 Myotonic Muscular Dystrophy 21685920 "As a consequence of miR-1 loss, expression of GJA1 (connexin 43) and CACNA1C (Cav1.2), which are targets of miR-1, is increased in both DM1- and DM2-affected hearts." -genetics_knock down_promote hsa-mir-135a-1 Medulloblastoma 21793975 deletion -genetics_knock down_promote hsa-mir-135a-2 Medulloblastoma 21793975 deletion or amplification -genetics_knock down_promote hsa-mir-135b Medulloblastoma 21793975 deletion or amplification -genetics_knock down_promote hsa-mir-186 Medulloblastoma 21793975 deletion -genetics_knock down_promote hsa-mir-33b Medulloblastoma 21793975 "deletion, amplification or a mutation at the precursor miRNA" -genetics_knock down_promote hsa-mir-512-2 Medulloblastoma 21793975 "deletion. Antisense-based knockdown of miR-512-5p (mature sequence of miR-512-2) resulted in significant upregulation of MYCC expression in HeLa and A549 cells, while forced overexpression of miR-512-2 in medulloblastoma/PNET cell lines DAOY, UW-228-2, PFSK resulted in downregulation of MYCC protein." -genetics_knock down_promote hsa-mir-548d-1 Medulloblastoma 21793975 deletion -genetics_knock down_promote hsa-mir-548d-2 Medulloblastoma 21793975 deletion -genetics_knock down_promote hsa-mir-132 Progressive Supranuclear Palsy 21807765 "MicroRNA-132 loss is associated with tau exon 10 inclusion in Supranuclear Palsy, Progressive." -genetics_knock down_promote hsa-mir-101-1 Lung Neoplasms 21849855 miR-101 DNA Copy Loss is a Prominent Subtype Specific Event in Lung Cancer. -genetics_knock down_promote hsa-mir-101-2 Lung Neoplasms 21849855 miR-101 DNA Copy Loss is a Prominent Subtype Specific Event in Lung Cancer. -genetics_knock down_promote hsa-mir-145 Myelodysplastic Syndromes 21873545 miR-145 affects megakaryocyte and erythroid differentiation.Patients with del(5q) MDS have decreased expression of miR-145 and increased expression of Fli-1. Combined loss of miR-145 and RPS14 cooperate to alter erythroid-megakaryocytic differentiation in a manner similar to the 5q- syndrome. -genetics_knock down_promote hsa-mir-17 Musculoskeletal Abnormalities [unspecific] 21892160 Germline deletion of the miR-17-92 cluster causes skeletal and growth defects in humans. -genetics_knock down_promote hsa-mir-18a Musculoskeletal Abnormalities [unspecific] 21892160 Germline deletion of the miR-17-92 cluster causes skeletal and growth defects in humans. -genetics_knock down_promote hsa-mir-19a Musculoskeletal Abnormalities [unspecific] 21892160 Germline deletion of the miR-17-92 cluster causes skeletal and growth defects in humans. -genetics_knock down_promote hsa-mir-19b-1 Musculoskeletal Abnormalities [unspecific] 21892160 Germline deletion of the miR-17-92 cluster causes skeletal and growth defects in humans. -genetics_knock down_promote hsa-mir-20a Musculoskeletal Abnormalities [unspecific] 21892160 Germline deletion of the miR-17-92 cluster causes skeletal and growth defects in humans. -genetics_knock down_promote hsa-mir-92a-1 Musculoskeletal Abnormalities [unspecific] 21892160 Germline deletion of the miR-17-92 cluster causes skeletal and growth defects in humans. -genetics_knock down_promote hsa-mir-21 Hypertension 21920918 "Induction of miR-21 and miR-27a may be a critical component of BMP-induced growth suppression, loss of which likely contributes to vascular cell proliferation in HPAH (Heritable pulmonary arterial hypertension)." -genetics_knock down_promote hsa-mir-101-1 Pancreatic Neoplasms 21932133 Loss of MicroRNA-101 Promotes Overexpression of Histone Methyltransferase EZH2. -genetics_knock down_promote hsa-mir-101-2 Pancreatic Neoplasms 21932133 Loss of MicroRNA-101 Promotes Overexpression of Histone Methyltransferase EZH2. -genetics_knock down_promote hsa-mir-101-1 "Carcinoma, Lung, Non-Small-Cell" 21993632 "Down-regulation of miR-101 was associated with overexpression of Mcl-1 mRNA in NSCLC tissue when compared with corresponding normal tissue, with a negative correlation (r = -0.724, P < 0.01). MiR-101 expression was significantly associated with pathological stage (P = 0.004) and lymph node involvement (P = 0.012). Overexpression of Mcl-1 was associated with pathological grade (P = 0.022) and lymph node involvement (P = 0.017). A comparison of survival curves of low versus high expressers of miR-101 and Mcl-1 revealed a highly significant difference in NSCLC (P < 0.05), which suggests that reduced expression of miR-101 versus overexpression of Mcl-1 is associated with a poorer prognosis." -genetics_knock down_promote hsa-mir-101-2 "Carcinoma, Lung, Non-Small-Cell" 21993632 "Down-regulation of miR-101 was associated with overexpression of Mcl-1 mRNA in NSCLC tissue when compared with corresponding normal tissue, with a negative correlation (r = -0.724, P < 0.01). MiR-101 expression was significantly associated with pathological stage (P = 0.004) and lymph node involvement (P = 0.012). Overexpression of Mcl-1 was associated with pathological grade (P = 0.022) and lymph node involvement (P = 0.017). A comparison of survival curves of low versus high expressers of miR-101 and Mcl-1 revealed a highly significant difference in NSCLC (P < 0.05), which suggests that reduced expression of miR-101 versus overexpression of Mcl-1 is associated with a poorer prognosis." -genetics_knock down_promote hsa-mir-144 Thyroid Neoplasms 22049245 miR-199b-5p and miR-144 which were essentially lost in the carcinomas. -genetics_knock down_promote hsa-mir-199b Thyroid Neoplasms 22049245 miR-199b-5p and miR-144 which were essentially lost in the carcinomas. -genetics_knock down_promote hsa-mir-29a Kidney Diseases [unspecific] 22095944 Suppression of microRNA-29 Expression by TGF-beta1 Promotes Collagen Expression and Renal Fibrosis. -genetics_knock down_promote hsa-mir-29b-1 Kidney Diseases [unspecific] 22095944 Suppression of microRNA-29 Expression by TGF-beta1 Promotes Collagen Expression and Renal Fibrosis. -genetics_knock down_promote hsa-mir-29b-2 Kidney Diseases [unspecific] 22095944 Suppression of microRNA-29 Expression by TGF-beta1 Promotes Collagen Expression and Renal Fibrosis. -genetics_knock down_promote hsa-mir-29c Kidney Diseases [unspecific] 22095944 Suppression of microRNA-29 Expression by TGF-beta1 Promotes Collagen Expression and Renal Fibrosis. -genetics_knock down_promote hsa-mir-122 Hepatitis B Virus Infection 22105316 Loss of MiR-122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G1 modulated P53 activity. -genetics_knock down_promote hsa-mir-34a Rheumatoid Arthritis 22161761 Downregulation of microRNA-34a* in rheumatoid arthritis synovial fibroblasts promotes apoptosis resistance. -genetics_knock down_promote hsa-mir-124-1 Glioma 22253443 Loss of brain-enriched miR-124 enhances the stem-like traits and invasiveness of glioma cells. -genetics_knock down_promote hsa-mir-124-2 Glioma 22253443 Loss of brain-enriched miR-124 enhances the stem-like traits and invasiveness of glioma cells. -genetics_knock down_promote hsa-mir-124-3 Glioma 22253443 Loss of brain-enriched miR-124 enhances the stem-like traits and invasiveness of glioma cells. -genetics_knock down_promote hsa-mir-145 Ovarian Neoplasms 22285623 The loss of miR-145 can result in the activation of factors that promote oncogenesis and cellular pluripotency which in turn could lead to the development of ovarian cancer. -genetics_knock down_promote hsa-mir-133a-1 Breast Neoplasms 22292984 Loss of miR-133a expression associated with poor survival of breast cancer and restoration of miR-133a expression inhibited breast cancer cell growth and invasion. -genetics_knock down_promote hsa-mir-133a-2 Breast Neoplasms 22292984 Loss of miR-133a expression associated with poor survival of breast cancer and restoration of miR-133a expression inhibited breast cancer cell growth and invasion. -genetics_knock down_promote hsa-mir-29a "Muscular Dystrophy, Duchenne" 22434133 Loss of miR-29 in Myoblasts Contributes to Dystrophic Muscle Pathogenesis. -genetics_knock down_promote hsa-mir-29b-1 "Muscular Dystrophy, Duchenne" 22434133 Loss of miR-29 in Myoblasts Contributes to Dystrophic Muscle Pathogenesis. -genetics_knock down_promote hsa-mir-29b-2 "Muscular Dystrophy, Duchenne" 22434133 Loss of miR-29 in Myoblasts Contributes to Dystrophic Muscle Pathogenesis. -genetics_knock down_promote hsa-mir-29c "Muscular Dystrophy, Duchenne" 22434133 Loss of miR-29 in Myoblasts Contributes to Dystrophic Muscle Pathogenesis. -genetics_knock down_promote hsa-mir-101-1 Gastric Neoplasms 22450781 Lack of microRNA-101 causes E-cadherin functional deregulation through EZH2 upregulation in intestinal gastric cancer. -genetics_knock down_promote hsa-let-7c Prostate Neoplasms 22479342 MicroRNA let-7c Is Downregulated in Prostate Cancer and Suppresses Prostate Cancer Growth. -genetics_knock down_promote hsa-mir-205 Melanoma 22525428 Loss of microRNA-205 expression is associated with melanoma progression. -genetics_knock down_promote hsa-let-7g Melanoma 22551973 The downregulation of this miRNA was associated with selective genomic loss in SSM cell lines and primary tumors. -genetics_knock down_promote hsa-mir-126 Pancreatic Neoplasms 22845403 Loss of miR-126 is crucial to pancreatic cancer progression. -genetics_knock down_promote hsa-mir-148a Endometrial Neoplasms 22890324 Silencing of miR-148a in cancer-associated fibroblasts results in WNT10B-mediated stimulation of tumor cell motility. -genetics_knock down_promote hsa-mir-218-1 Breast Neoplasms 22898079 Silencing of miRNA-218 promotes migration and invasion of breast cancer via Slit2-Robo1 pathway. -genetics_knock down_promote hsa-mir-218-2 Breast Neoplasms 22898079 Silencing of miRNA-218 promotes migration and invasion of breast cancer via Slit2-Robo1 pathway. -genetics_knock down_promote hsa-mir-101-1 Colon Neoplasms 22930392 Loss of miR-101 Expression Promotes Wnt/beta-Catenin Signalling Pathway Activation and Malignancy in Colon Cancer Cells. -genetics_knock down_promote hsa-mir-200a Melanoma 22956368 "Loss of microRNA-200a and c, and microRNA-203 expression at the invasive front of primary cutaneous melanoma is associated with increased thickness and disease progression." -genetics_knock down_promote hsa-mir-200c Melanoma 22956368 "Loss of microRNA-200a and c, and microRNA-203 expression at the invasive front of primary cutaneous melanoma is associated with increased thickness and disease progression." -genetics_knock down_promote hsa-mir-203 Melanoma 22956368 "Loss of microRNA-200a and c, and microRNA-203 expression at the invasive front of primary cutaneous melanoma is associated with increased thickness and disease progression." -genetics_knock down_promote hsa-mir-370 Cholangiocarcinoma 23110045 Silencing of miR-370 in human cholangiocarcinoma by allelic loss and interleukin-6 induced maternal to paternal epigenotype switch -genetics_knock down_promote hsa-mir-126 Heart Failure 23136161 Loss of AngiomiR-126 and 130a in Angiogenic Early Outgrowth Cells From Patients With Chronic Heart Failure: Role for Impaired In Vivo Neovascularization and Cardiac Repair Capacity -genetics_knock down_promote hsa-mir-130a Heart Failure 23136161 Loss of AngiomiR-126 and 130a in Angiogenic Early Outgrowth Cells From Patients With Chronic Heart Failure: Role for Impaired In Vivo Neovascularization and Cardiac Repair Capacity -genetics_knock down_promote hsa-mir-204 Glioma 23204229 Loss of miR-204 Expression Enhances Glioma Migration and Stem Cell-like Phenotype -genetics_knock down_promote hsa-mir-132 Osteosarcoma 23801049 Loss of microRNA-132 predicts poor prognosis in patients with primary osteosarcoma. -genetics_knock down_promote hsa-let-7 Prostate Neoplasms 23977098 "MSCs co-evolve with prostate cancer cells in the tumor microenvironment, and the downregulation of let-7 by cancer-associated MSCs upregulates IL-6 expression." -genetics_knock down_promote hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 24026141 "There was a significantly decreased expression of both miRNAs in patients with biallelic deletion of the 13q14 region but only when deletions were present in 77% or more of cells, as detected by fluorescent in situ hybridization (FISH)." -genetics_knock down_promote hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 24026141 "There was a significantly decreased expression of both miRNAs in patients with biallelic deletion of the 13q14 region but only when deletions were present in 77% or more of cells, as detected by fluorescent in situ hybridization (FISH)." -genetics_knock down_promote hsa-mir-21 Ischemia-Reperfusion Injury 24098402 Our data clearly demonstrate that miR-21 is involved in IPost-mediated cardiac protection against I/R injury and dysfunction through the PTEN/Akt signaling pathway in vivo. -genetics_knock down_promote hsa-mir-10a Neoplasms [unspecific] 24204315 Loss of miR-10a activates lpo and collaborates with activated Wnt signaling in inducing intestinal neoplasia in female mice. -genetics_knock down_promote hsa-mir-200a Breast Neoplasms 24280074 Loss of microRNA-200a expression correlates with tumor progression in breast cancer. -genetics_knock down_promote hsa-mir-126 Prostate Neoplasms 24350576 These findings suggest for the first time that the loss of miR-126 expression may play a positive role in the malignant progression of PCa. -genetics_knock down_promote hsa-mir-214 "Carcinoma, Nasopharyngeal" 24465927 Knockdown of miR-214 promotes apoptosis and inhibits cell proliferation in nasopharyngeal carcinoma. -genetics_knock down_promote hsa-mir-223 Sepsis 24486439 "Taken together, these data indicate that loss of miR-223/-223* causes an aggravation of sepsis-induced inflammation, myocardial dysfunction and mortality." -genetics_knock down_promote hsa-mir-206 Amyotrophic Lateral Sclerosis 24664281 "in mutant mice lacking miR-206, reinnervation is impaired following nerve injury and loss of NMJs is accelerated in a mouse model of amyotrophic lateral sclerosis (ALS)." -genetics_knock down_promote hsa-mir-145 "Carcinoma, Hepatocellular" 24690171 "Our results demonstrated that miR-145 could inhibit HCC through targeting IRS1 and its downstream signaling, implicating the loss of miR-145 regulation may be a potential molecular mechanism causing aberrant oncogenic signaling in HCC." -genetics_knock down_promote hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 24732594 Allele-specific loss and transcription of the miR-15a/16-1 cluster in chronic lymphocytic leukemia. -genetics_knock down_promote hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 24732594 Allele-specific loss and transcription of the miR-15a/16-1 cluster in chronic lymphocytic leukemia. -genetics_knock down_promote hsa-mir-21 Pulmonary Hypertension 24732886 "In vivo, genetic deletion of microRNA-21 in mice (miR-21(-/-) mice) resulted in functional activation of the PDCD4/caspase-3 axis in the pulmonary tissues, leading to the onset of progressive PH." -genetics_knock down_promote hsa-mir-424 Hepatoblastoma 24796297 "Furthermore, miR-424 or miR-503 depletion enhanced extravasation to the lungs of hepatocarcinoma cells injected in the tail vein of mice." -genetics_knock down_promote hsa-mir-100 Prostate Neoplasms 24805183 "Loss of miR-100 enhances migration, invasion, epithelial-mesenchymal transition and stemness properties in prostate cancer cells through targeting Argonaute 2." -genetics_knock down_promote hsa-mir-451a "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 24918822 Loss of tumour suppressive miR-451a enhanced cancer cell migration and invasion in HSCC through direct regulation of ESDN. Our miRNA signature and functional analysis of targets regulated by tumour suppressive miR-451a provide new insights into the potential mechanisms of HSCC oncogenesis and metastasis. -genetics_knock down_promote hsa-mir-17 Atrial Fibrillation 24927531 "miR-17-92 and miR-106b-25 directly repress genes, such as Shox2 and Tbx3, that are required for sinoatrial node development.Together, to our knowledge, these findings provide the first genetic evidence for an miR loss-of-function that increases atrial fibrillation susceptibility." -genetics_knock down_promote hsa-mir-18 Atrial Fibrillation 24927531 "miR-17-92 and miR-106b-25 directly repress genes, such as Shox2 and Tbx3, that are required for sinoatrial node development.Together, to our knowledge, these findings provide the first genetic evidence for an miR loss-of-function that increases atrial fibrillation susceptibility." -genetics_knock down_promote hsa-mir-19a Atrial Fibrillation 24927531 "miR-17-92 and miR-106b-25 directly repress genes, such as Shox2 and Tbx3, that are required for sinoatrial node development.Together, to our knowledge, these findings provide the first genetic evidence for an miR loss-of-function that increases atrial fibrillation susceptibility." -genetics_knock down_promote hsa-mir-19b-1 Atrial Fibrillation 24927531 "miR-17-92 and miR-106b-25 directly repress genes, such as Shox2 and Tbx3, that are required for sinoatrial node development.Together, to our knowledge, these findings provide the first genetic evidence for an miR loss-of-function that increases atrial fibrillation susceptibility." -genetics_knock down_promote hsa-mir-20a Atrial Fibrillation 24927531 "miR-17-92 and miR-106b-25 directly repress genes, such as Shox2 and Tbx3, that are required for sinoatrial node development.Together, to our knowledge, these findings provide the first genetic evidence for an miR loss-of-function that increases atrial fibrillation susceptibility." -genetics_knock down_promote hsa-mir-92-1 Atrial Fibrillation 24927531 "miR-17-92 and miR-106b-25 directly repress genes, such as Shox2 and Tbx3, that are required for sinoatrial node development.Together, to our knowledge, these findings provide the first genetic evidence for an miR loss-of-function that increases atrial fibrillation susceptibility." -genetics_knock down_promote hsa-mir-203 Prostate Neoplasms 24980827 Loss of tumor suppressor mir-203 mediates overexpression of LIM and SH3 Protein 1 (LASP1) in high-risk prostate cancer thereby increasing cell proliferation and migration. -genetics_knock down_promote hsa-mir-155 Melanoma 25143000 Our current study showed that both B16-F10 melanoma and Lewis lung carcinoma tumors grew much faster in bic/miR-155 knockout (miR-155(-/-) ) mice -genetics_knock down_promote hsa-mir-378 Prostate Neoplasms 25153390 "Loss of miR-378 in prostate cancer, a common regulator of KLK2 and KLK4, correlates with aggressive disease phenotype and predicts the short-term relapse of the patients." -genetics_knock down_promote hsa-mir-100 "Carcinoma, Hepatocellular" 25361001 Downregulation of microRNA-100 enhances the ICMT-Rac1 signaling and promotes metastasis of hepatocellular carcinoma cells. -genetics_knock down_promote hsa-mir-101 "Carcinoma, Esophageal" 25400732 decreased expression of miR-101 might promote metastasis of human ESCC by inducing accumulation of EZH2 protein. -genetics_knock down_promote hsa-mir-101 Lung Neoplasms 25428391 "particle can induce the secretion of interleukin-1¦Â. Interleukin-1¦Â subsequently induces the downregulation of mir-101, which may result in the upregulated level of EZH2, and occurrence of lung cancer. We for the first time proposed the role interleukin-1¦Â-mir-101-EZH2 axes in the particle-induced lung cancer. Further study may be needed to decipher the detailed mechanism involved." -genetics_knock down_promote hsa-mir-34a Prostate Neoplasms 25436980 "the bone metastasis and anti-apoptotic effects found in Ras signaling-activated prostate cancer cells require miR-34a deficiency, which in turn aids in cell survival by activating the WNT and anti-apoptotic signaling pathways thereby inducing TCF7 and BIRC5 expressions." -genetics_knock down_promote hsa-mir-34a Diabetes Mellitus 25483877 "Knockdown of miR-34a slightly decreased proliferation, but as apoptosis and NO synthesis were highly reduced, miR-34a may be further investigated as a therapeutic target to reduce β-cell death and dysfunction." -genetics_knock down_promote hsa-mir-7 Breast Neoplasms 25532106 Suppression of miR-7 in the MCF-7 cell line resulted in enhanced colony formation activity but not cell migration -genetics_knock down_promote hsa-mir-204 Prostate Neoplasms 25630658 "not only tumor suppressor micro-RNA loss, but also significant genome rearrangement-driven regulatory loop perturbations play a role in the advanced cancer progression, conferring better pro-survival and metastatic potential." -genetics_knock down_promote hsa-mir-26a Neoplasms [unspecific] 25668004 Loss of tumour-suppressive miR-26a/b enhanced cancer cell migration and invasion in OSCC through direct regulation of TMEM184B. Our data describing pathways regulated by tumour-suppressive miR-26a/b provide new insights into the potential mechanisms of OSCC oncogenesis and metastasis. -genetics_knock down_promote hsa-mir-26b Neoplasms [unspecific] 25668004 Loss of tumour-suppressive miR-26a/b enhanced cancer cell migration and invasion in OSCC through direct regulation of TMEM184B. Our data describing pathways regulated by tumour-suppressive miR-26a/b provide new insights into the potential mechanisms of OSCC oncogenesis and metastasis. -genetics_knock down_promote hsa-mir-1 Prostate Neoplasms 25802280 Our data support the existence of an AR-miR-1-SRC regulatory network.We propose that loss of miR-1 is one mechanistic link between low canonical Androgen receptor (AR) output and SRC-promoted metastatic phenotypes. -genetics_knock down_promote hsa-mir-23a Idiopathic Pulmonary Hypertension 25815108 "Finally we found that silencing of miR23a resulted in an increase of the expression of PGC1¦Á, as well as in its well-known regulated genes CYC, SOD, NRF2,and HO1. The results point to the utility of circulating miRNA expression as a biomarker of disease progression." -genetics_knock down_promote hsa-mir-146b "Carcinoma, Thyroid, Papillary" 25819770 "The results showed that PTC cells overexpress miR-146b and miR-222 in exosomes; and that factors released by both normal thyroid and PTC cells alter proliferation of other cells in a complex manner. The intercellular interactions were likely conferred in part by exosomal miRNA, which can potentially be developed as biomarkers of PTC recurrence." -genetics_knock down_promote hsa-mir-222 "Carcinoma, Thyroid, Papillary" 25819770 "The results showed that PTC cells overexpress miR-146b and miR-222 in exosomes; and that factors released by both normal thyroid and PTC cells alter proliferation of other cells in a complex manner. The intercellular interactions were likely conferred in part by exosomal miRNA, which can potentially be developed as biomarkers of PTC recurrence." -genetics_knock down_promote hsa-mir-150 Heart Failure 25824147 we show that genetic deletion of miR-150 in mice causes abnormalities in cardiac structural and functional remodelling after MI. -genetics_knock down_promote hsa-mir-150 Myocardial Infarction 25824147 we show that genetic deletion of miR-150 in mice causes abnormalities in cardiac structural and functional remodelling after MI. -genetics_knock down_promote hsa-mir-155 "Lymphoma, B-Cell" 25829072 "A deficiency of miR-155 in the immune system causes attenuated immune functions. Clinically, several types of malignancy including diffuse large B-cell lymphoma have high miR-155 expression levels." -genetics_knock down_promote hsa-mir-21 Acute Kidney Failure 25844699 "Knockdown of miR-21 upregulated its target effectors programmed cell death protein 4 and phosphatase and tensin homolog deleted on chromosome 10 expression, resulted in an increase in apoptosis, and exacerbated lipopolysaccharide-induced acute kidney injury." -genetics_knock down_promote hsa-mir-155 Mycobacterium tuberculosis Infection 25846955 "Following infection, miR-155-deficient C57BL/6 mice died significantly earlier and had significantly higher numbers of CFU in lungs than wild-type mice." -genetics_knock down_promote hsa-mir-377 Lymphoma 25889255 Our results suggest that miR-377 is an important negative regulator of E2F and MAP3K7/NF-kB signaling pathway in melanoma cells; it is tempting to speculate that its silencing in melanoma promotes the tumorigenic and metastatic potential of the cells through activation of these pathways. -genetics_knock down_promote hsa-mir-142 Primary Immunodeficiency Disease 25931583 "miR-142 as an essential regulator of lymphopoiesis, and suggest that lesions in this miRNA gene may lead to primary immunodeficiency." -genetics_knock down_promote hsa-mir-132 Inflammation 26052826 Blockage of miR-132 using miR-132 inhibitor reversed the Ach action upon LPS-induced release of inflammatory mediators and reduction in AchE protein/activity. -genetics_knock down_promote hsa-mir-205 Prostate Neoplasms 26059417 Loss of tumor-suppressive microRNA-205 seems to enhance cancer cell migration and invasion in prostate cancer through direct regulation of centromere protein F. Our data describing pathways regulated by tumor-suppressive microRNA-205 provide new insights into the potential mechanisms of prostate cancer oncogenesis and metastasis. -genetics_knock down_promote hsa-mir-133a Heart Failure 26064437 attenuation of miR-133a contributes to the exacerbation of diabetes mediated cardiac autophagy and hypertrophy in heart failure -genetics_knock down_promote hsa-mir-133a Hypertrophy 26064437 attenuation of miR-133a contributes to the exacerbation of diabetes mediated cardiac autophagy and hypertrophy in heart failure -genetics_knock down_promote hsa-mir-21 "Carcinoma, Hepatocellular" 26282675 "microRNA-21 knockdown led to increased HBP1 and p53 and subsequently reduced lipogenesis and delayed G1/S transition, and the additional treatment of HBP1-siRNA antagonised the effect of microRNA-21-ASO, suggesting that HBP1 mediated the inhibitory effects of microRNA-21-ASO on both hepatic lipid accumulation and hepatocarcinogenesis." -genetics_knock down_promote hsa-mir-622 Colorectal Carcinoma 26333174 miR-622 inhibited tumor proliferation and migration in vitro. -genetics_knock down_promote hsa-mir-214 Parkinson Disease 26349993 "The loss of miR-214 in PD resulted in the increase of ¦Á-synuclein expression, which was the potential mechanism underlying the neuroprotective effects of Resveratrol." -genetics_knock down_promote hsa-mir-195 Cervical Neoplasms 26511972 reducing the endogenous miR-195 level by miR-195 inhibitor promoted the proliferation of cervical cancer cells. -genetics_knock down_promote hsa-mir-377 Ischemia-Reperfusion Injury 26564600 "These findings indicate that HF increased miR-377 expression in the myocardium, which is detrimental to stem cell function, and transplantation of miR-377 knockdown hCD34(+) cells into ischemic myocardium promoted their angiogenic ability, attenuating left ventricular remodeling and cardiac fibrosis." -genetics_knock down_promote hsa-mir-150 Sepsis 26743170 miR-150(-/-) mice died rapidly after sepsis. -genetics_knock down_promote hsa-mir-29b "Carcinoma, Renal Cell" 26823729 "Inhibition of miR-29b expression could promote apoptosis, and inhibit proliferation and invasion ability in SN12-PM6 cells." -genetics_knock down_promote hsa-mir-150 Obesity 26833392 miR-150KO mice displayed exacerbated obesity-associated tissue inflammation and systemic insulin resistance -genetics_knock down_promote hsa-mir-29c "Carcinoma, Embryonal" 26848028 "Inhibition of miRâ€?9c promoted proliferation, and suppressed the apoptosis and differentiation of P19 cells." -genetics_knock down_promote hsa-mir-196a Renal Fibrosis 26940097 depletion of renal miR-196a/b by miR-196a/b antagomirs substantially aggravated UUO-induced renal fibrosis. -genetics_knock down_promote hsa-mir-196b Renal Fibrosis 26940097 depletion of renal miR-196a/b by miR-196a/b antagomirs substantially aggravated UUO-induced renal fibrosis. -genetics_knock down_promote hsa-mir-126a Sepsis 26968021 "The down-regulation of miR-126a-3p in endothelial cells resulted in the increased apoptosis, and decreased proliferation and migration," -genetics_knock down_promote hsa-mir-124 Glioblastoma 26993295 inhibitor of miR-124 promoted the expression of STAT3 and cell proliferation. -genetics_knock down_promote hsa-mir-181 Autism Spectrum Disorder 27017280 this loss-of miR-181c function resulted in enhanced neurite sprouting and reduced synaptogenesis -genetics_knock down_promote hsa-mir-4282 Colorectal Carcinoma 27120047 "It was found that miR-4282 inhibition promoted cell growth, migration and invasion (P<0.05) of HT29 and HCT116 colorectal carcinoma cells while miR-4282 overexpression suppressed cell growth and mobility (P<0.05)." -genetics_knock down_promote hsa-mir-146a Ischemia-Reperfusion Injury 27250735 miR146a exerts a kidney protective effect through negative regulation of acute inflammatory response -genetics_knock down_promote hsa-mir-505 "Carcinoma, Hepatocellular" 27259809 "the up-regulation of miR-505 suppressed, whereas the down-regulation of miR-505 promoted proliferation, invasion and epithelial-mesenchymal transition in MHCC97." -genetics_knock down_promote hsa-mir-206 Rhabdomyosarcoma 27277678 Genetic deletion of miR-206 in a mouse model of FN-RMS accelerated and exacerbated tumor development -genetics_knock down_promote hsa-mir-150 Diabetic Retinopathy 27304911 deletion of miR-150 significantly increased the retinal pathological angiogenesis -genetics_knock down_promote hsa-mir-34a Obesity 27377585 miR-34a(-/-) mice are susceptible to diet-induced obesity. -genetics_knock down_promote hsa-mir-122 Pterygium 27415790 "Decreased expression of miR-122 in pterygium might result in abnormal cell apoptosis via its regulation of the expression of Bcl-w, and subsequently contribute to the development of pterygium." -genetics_knock down_promote hsa-mir-146a Ischemia-Reperfusion Injury 27444565 "After unilateral IRI, miR-146a-/- mice exhibited more extensive tubular injury, inflammatory infiltrates, and fibrosis than wild-type mice." -genetics_knock down_promote hsa-mir-145 Prostate Neoplasms 27465939 "ASC-derived conditioned medium (CM) significantly inhibited PC3M-luc2 cell proliferation, inducing apoptosis, but the effect was canceled by miR-145 knockdown in ASCs." -genetics_knock down_promote hsa-mir-200b "Squamous Cell Carcinoma, Esophageal" 27496804 "Correlating with the frequent loss of miR-200b in ESCC, both CDK2 and PAF levels are significantly increased in ESCC tumors compared to case-matched normal tissues." -genetics_knock down_promote hsa-mir-27a Rheumatoid Arthritis 27498552 "However, miR-27a inhibition promoted the migration and invasion of FLS." -genetics_knock down_promote hsa-mir-424 "Carcinoma, Lung, Non-Small-Cell" 27500472 It was found that down-regulation of miR-424-3p was pronouncedly associated with NSCLC progression and overall prognosis; -genetics_knock down_promote hsa-let-7 Kaposi Sarcoma 27531260 "Let-7 silencing may activate the replication of KSHV, possibly through up-regulating MAP4K4 and its downstream molecules COX-2, MMP-13, and phosphorylation of ERK1/2, finally results in the progression of Kaposi sarcoma." -genetics_knock down_promote hsa-mir-15a Leukemia 27533467 both miR-15a deficient HSC and B1P cells are capable of repopulating irradiated recipients and produce higher numbers of B1 cells than sources with normal miR-15a/16 levels. -genetics_knock down_promote hsa-mir-142 "Carcinoma, Hepatocellular" 28177895 Over-expression of Thrombospondin 4 correlates with loss of miR-142 and contributes to migration and vascular invasion of advanced hepatocellular carcinoma. -genetics_knock down_promote hsa-mir-7 Hypogonadotropic Hypogonadism 28218624 Loss of microRNA-7a2 induces hypogonadotropic hypogonadism and infertility. -genetics_knock down_promote hsa-mir-320a "Carcinoma, Hepatocellular" 28288874 Loss of exosomal miR-320a from cancer-associated fibroblasts contributes to HCC proliferation and metastasis. -genetics_knock down_promote hsa-mir-423 Glioma 28381178 miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway. -genetics_knock down_promote hsa-mir-126 "Carcinoma, Hepatocellular" 28639884 Loss of tumor suppressor miR-126 contributes to the development of hepatitis B virus-related hepatocellular carcinoma metastasis through the upregulation of ADAM9. -genetics_knock down_promote hsa-mir-200a "Squamous Cell Carcinoma, Oral" 29480379 lack of significant alterations in miR-31 and miR-200a levels in saliva of OLP patients may be indicative for absence of malignant transformation -genetics_knock down_promote hsa-mir-31 "Squamous Cell Carcinoma, Oral" 29480379 lack of significant alterations in miR-31 and miR-200a levels in saliva of OLP patients may be indicative for absence of malignant transformation -genetics_knock down_promote hsa-mir-146a Gout 29544526 "miR-146a provides negative feedback regulation of gouty arthritis development and lack of miR-146a enhances gouty arthritis via upregulation of TRAK6, IRAK-1, and the NALP3 inflammasome function" -genetics_knock down_promote hsa-mir-15a "Carcinoma, Lung, Non-Small-Cell" 29551936 Knocking down MiR-15a expression promotes the occurrence and development and induces the EMT of NSCLC cells in vitro -genetics_knock down_promote hsa-mir-125b "Leukemia, B-Cell" 29555645 physiological silencing of miR-125b is required for normal B-cell development and also acts as a mechanism of cancer suppression -genetics_knock down_promote hsa-mir-21 Spinal Cord Injuries 29934690 Knockdown of MicroRNA-21 Promotes Neurological Recovery After Acute Spinal Cord Injury. -genetics_knock down_promote hsa-mir-148b Endometrial Neoplasms 30146796 Loss of exosomal miR-148b from cancer-associated fibroblasts promotes endometrial cancer cell invasion and cancer metastasis. -genetics_knock down_promote hsa-mir-146b "Leukemia, Lymphoblastic, Acute, T-Cell" 30362152 Loss of miR-146b-5p promotes T cell acute lymphoblastic leukemia migration and invasion via the IL-17A pathway. -genetics_knock down_suppress hsa-mir-223 "Leukemia, Promyelocytic, Acute" 16325577 "In line with this, both RNAi against NFI-A and ectopic expression of miR-223 in acute promyelocytic leukemia (APL) cells enhance differentiation, whereas miR-223 knockdown inhibits the differentiation response to RA." -genetics_knock down_suppress hsa-mir-1-2 Chronic Heart Failure 17397913 deletion -genetics_knock down_suppress hsa-mir-24-1 Tourette Syndrome 17462786 "A mutation in the 3'UTR of the SLITRK1 gene which is associated with Tourette's syndrome was found to enhance repression of the SLITRK mRNA by miR-189, presumably preventing SLITRK1's promotion of dendritic growth." -genetics_knock down_suppress hsa-let-7a-1 Colon Neoplasms 17965831 "Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers." -genetics_knock down_suppress hsa-let-7a-1 Lung Neoplasms 17965831 "Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers." -genetics_knock down_suppress hsa-let-7a-2 Colon Neoplasms 17965831 "Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers." -genetics_knock down_suppress hsa-let-7a-2 Lung Neoplasms 17965831 "Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers." -genetics_knock down_suppress hsa-let-7a-3 Colon Neoplasms 17965831 "Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers." -genetics_knock down_suppress hsa-let-7a-3 Lung Neoplasms 17965831 "Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers." -genetics_knock down_suppress hsa-let-7b Colon Neoplasms 17965831 "Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers." -genetics_knock down_suppress hsa-let-7b Lung Neoplasms 17965831 "Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers." -genetics_knock down_suppress hsa-let-7c Colon Neoplasms 17965831 "Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers." -genetics_knock down_suppress hsa-let-7c Lung Neoplasms 17965831 "Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers." -genetics_knock down_suppress hsa-let-7d Colon Neoplasms 17965831 "Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers." -genetics_knock down_suppress hsa-let-7d Lung Neoplasms 17965831 "Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers." -genetics_knock down_suppress hsa-let-7e Colon Neoplasms 17965831 "Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers." -genetics_knock down_suppress hsa-let-7e Lung Neoplasms 17965831 "Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers." -genetics_knock down_suppress hsa-let-7f-1 Colon Neoplasms 17965831 "Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers." -genetics_knock down_suppress hsa-let-7f-1 Lung Neoplasms 17965831 "Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers." -genetics_knock down_suppress hsa-let-7f-2 Colon Neoplasms 17965831 "Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers." -genetics_knock down_suppress hsa-let-7f-2 Lung Neoplasms 17965831 "Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers." -genetics_knock down_suppress hsa-let-7g Colon Neoplasms 17965831 "Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers." -genetics_knock down_suppress hsa-let-7g Lung Neoplasms 17965831 "Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers." -genetics_knock down_suppress hsa-let-7i Colon Neoplasms 17965831 "Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers." -genetics_knock down_suppress hsa-let-7i Lung Neoplasms 17965831 "Furthermore, a reduction in the expression of let-7 was associated with lung cancers and in particular with reduced survival./ Mayr et al. demonstrated that a chromosomal translocation at 12q5 disrupts let-7 expression and consequently curtails inhibition of the oncogene High Mobility Group A2 (Hmga2). Let-7 has also been implicated in the development of colon cancers and the progression of colorectal cancers." -genetics_knock down_suppress hsa-mir-221 Carotid Artery Diseases 19150885 miR-221: knockdown of miR-221 and miR-222 in rat carotid arteries suppressed VSMC proliferation in vivo and neointimal lesion formation after angioplasty. The results indicate that miR-221 and miR-222 are novel regulators for VSMC proliferation and neointimal hype -genetics_knock down_suppress hsa-mir-222 Carotid Artery Diseases 19150885 miR-222: knockdown of miR-221 and miR-222 in rat carotid arteries suppressed VSMC proliferation in vivo and neointimal lesion formation after angioplasty. The results indicate that miR-221 and miR-222 are novel regulators for VSMC proliferation and neointimal hype -genetics_knock down_suppress hsa-mir-10b Myocardial Infarction 19595696 Knockdown of microRNA-181 by lentivirus decreases the arrhythmogenic effect of skeletal myoblast transplantation in rat with myocardial infarction. -genetics_knock down_suppress hsa-mir-150 "Carcinoma, Hepatocellular" 19617899 repressed in a subset of primary tumorscharacterized by poor prognosis; loss of miR-122 expression correlates with suppression of the hepatic phenotype and gain of metastatic properties; a diagnostic and prognostic marker -genetics_knock down_suppress hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 19744129 "Their aberrant expression has been associated with solid tumors and hematopoietic malignancies as suggested by the frequent deletion of mir-15a and mir-16-1 in chronic lymphocytic leukemia, the increased levels of mir-155 in diffuse large B-cell lymphomas and the increased levels of mir-181 in acute myeloid leukemia M1 and M2. " -genetics_knock down_suppress hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 19744129 "Their aberrant expression has been associated with solid tumors and hematopoietic malignancies as suggested by the frequent deletion of mir-15a and mir-16-1 in chronic lymphocytic leukemia, the increased levels of mir-155 in diffuse large B-cell lymphomas and the increased levels of mir-181 in acute myeloid leukemia M1 and M2. " -genetics_knock down_suppress hsa-mir-126 Asthma 19843690 Selective blockade of microRNA (miR)-126 suppressed the asthmatic phenotype -genetics_knock down_suppress hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 20129242 miR-15a and miR-16-1 were the first microRNAs linked to cancer because their genes are commonly deleted in human chronic lymphocytic leukemia (CLL) -genetics_knock down_suppress hsa-let-7a-1 Neoplasms [unspecific] 20614490 let-7a:Gastric carcinoma has relatively lower expression of let-7a -genetics_knock down_suppress hsa-let-7a-2 Neoplasms [unspecific] 20614490 let-7a:Gastric carcinoma has relatively lower expression of let-7a -genetics_knock down_suppress hsa-let-7a-3 Neoplasms [unspecific] 20614490 let-7a:Gastric carcinoma has relatively lower expression of let-7a -genetics_knock down_suppress hsa-mir-200a Neoplasms [unspecific] 20832727 miR-200a:Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells -genetics_knock down_suppress hsa-mir-200b Neoplasms [unspecific] 20832727 miR-200b:Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells -genetics_knock down_suppress hsa-mir-200c Neoplasms [unspecific] 20832727 miR-200c:Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells -genetics_knock down_suppress hsa-mir-21 Breast Neoplasms 21219636 "In vitro assays showed that ERBB2 is a direct target of miR-125a-5p, which potently suppressed the proliferation of gastric cancer cells" -genetics_knock down_suppress hsa-mir-221 "Carcinoma, Hepatocellular" 22009537 miR-221 silencing blocks hepatocellular carcinoma and promotes survival. -genetics_knock down_suppress hsa-mir-124-1 Neuroblastoma 22024478 "Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR." -genetics_knock down_suppress hsa-mir-124-2 Neuroblastoma 22024478 "Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR." -genetics_knock down_suppress hsa-mir-124-3 Neuroblastoma 22024478 "Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR." -genetics_knock down_suppress hsa-mir-183 "Carcinoma, Thyroid, Medullary" 22024754 MiR-183 knockdown in an MTC cell line (TT cells) reduced cellular proliferation in association with elevated LC3B expression. -genetics_knock down_suppress hsa-mir-143 Neoplasms [unspecific] 22330136 Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop. -genetics_knock down_suppress hsa-mir-145 Neoplasms [unspecific] 22330136 Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop. -genetics_knock down_suppress hsa-mir-122 Hepatitis C Virus Infection 22898980 The use of an HSP90 inhibitor or knockdown of HSP90 decreased GW182 and miR-122 expression and significantly reduced HCV replication. -genetics_knock down_suppress hsa-mir-181b-1 "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 22916024 Deletion of mir-181a-1/b-1 expression inhibits the development of Notch1 oncogene-induced T cell acute lymphoblastic leukemia (T-ALL). mir-181a-1/b-1 controls the strength and threshold of Notch activity in tumorigenesis in part by dampening multiple negative feedback regulators downstream of NOTCH and pre-T cell receptor (TCR) signaling pathways. -genetics_knock down_suppress hsa-mir-21 Heart Failure 22923342 "Atrial miR-21 knockdown suppresses atrial fibrosis and AF promotion, implicating miR-21 as an important signaling molecule for the AF substrate and pointing to miR-21 as a potential target for molecular interventions designed to prevent AF" -genetics_knock down_suppress hsa-let-7i "Carcinoma, Renal Cell" 22926558 "We also validated the prognostic value of miRNA let-7i in RCC. miR-138, located in chromosome 3p deletion, was also found to have suppressive effects on tumor proliferation and migration abilities." -genetics_knock down_suppress hsa-mir-138-1 "Carcinoma, Renal Cell" 22926558 "We also validated the prognostic value of miRNA let-7i in RCC. miR-138, located in chromosome 3p deletion, was also found to have suppressive effects on tumor proliferation and migration abilities." -genetics_knock down_suppress hsa-mir-138-2 "Carcinoma, Renal Cell" 22926558 "We also validated the prognostic value of miRNA let-7i in RCC. miR-138, located in chromosome 3p deletion, was also found to have suppressive effects on tumor proliferation and migration abilities." -genetics_knock down_suppress hsa-mir-21 Glioma 23077620 Silencing of microRNA-21 confers radio-sensitivity through inhibition of the PI3K/AKT pathway and enhancing autophagy in malignant glioma cell lines -genetics_knock down_suppress hsa-mir-150 Leukemia 23079661 Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia -genetics_knock down_suppress hsa-mir-204 Neoplasms [unspecific] 23285024 Genomic Loss of Tumor Suppressor miRNA-204 Promotes Cancer Cell Migration and Invasion by Activating AKT/mTOR/Rac1 Signaling and Actin Reorganization -genetics_knock down_suppress hsa-mir-21 Ischemia-Reperfusion Injury 23681145 "Knockdown of miR-21 induced significant up-regulation of programmed cell death protein 4 and phosphatase and tensin homolog deleted on chromosome 10, two proapoptotic target effectors of miR-21, and resulted in significant down-regulation of phosphorylated protein kinase B and increased tubular cell apoptosis." -genetics_knock down_suppress hsa-mir-21 Glioblastoma 23732394 Silencing of miR-21 by locked nucleic acid-lipid nanocapsule complexes sensitize human glioblastoma cells to radiation-induced cell death. -genetics_knock down_suppress hsa-mir-18a Immune System Disease [unspecific] 24131405 Treatment of cells with a microRNA-18a mimic in PCPS (PCPS/miR-18) knocked down 90% expression of the microRNA-18a target gene ATM. -genetics_knock down_suppress hsa-mir-17 Medulloblastoma 24145352 Silencing of the miR-17~92 cluster family inhibits medulloblastoma progression. -genetics_knock down_suppress hsa-mir-19a Medulloblastoma 24145352 Silencing of the miR-17~92 cluster family inhibits medulloblastoma progression. -genetics_knock down_suppress hsa-mir-23a "Squamous Cell Carcinoma, Head and Neck" 24317043 Transfection with anti-miR-23a inhibited the proliferation of HN4 cells and induced cell apoptosis. -genetics_knock down_suppress hsa-mir-196b "Leukemia, Myeloid, Acute" 24334453 "Therapeutic inhibition of microRNA-21 and microRNA-196b inhibited in vitro leukemic colony forming activity and depleted in vivo leukemia-initiating cell activity of HOX-based leukemias, which led to leukemia-free survival in a murine AML model and delayed disease onset in xenograft models." -genetics_knock down_suppress hsa-mir-21 "Leukemia, Myeloid, Acute" 24334453 "Therapeutic inhibition of microRNA-21 and microRNA-196b inhibited in vitro leukemic colony forming activity and depleted in vivo leukemia-initiating cell activity of HOX-based leukemias, which led to leukemia-free survival in a murine AML model and delayed disease onset in xenograft models." -genetics_knock down_suppress hsa-mir-92a "Leukemia, Promyelocytic, Acute" 24385779 Down-regulation of miR-92a in APL cell line (HL-60) by LNA antagomir extensively decreased cell viability in APL. -genetics_knock down_suppress hsa-let-7b Neoplasms [unspecific] 24423609 Reduction of let-7a3/let-7b miRNA may be one of mechanisms leading to overexpression of HMGA2 in AT/RT tissues. -genetics_knock down_suppress hsa-mir-21 Heart Failure 24551276 "After injection of miR-21 antagonist, the the cardiac atrophy and cardiac fibrosis were conspicuously ameliorated." -genetics_knock down_suppress hsa-mir-92a "Leukemia, Promyelocytic, Acute" 24627869 The assessment of the apoptosis and necrosis indicates that miR-92a inhibition can decrease the viable HL-60 cells and this is at least partially due to induction of apoptosis. -genetics_knock down_suppress hsa-mir-17 Multiple Sclerosis 24644282 T cell-specific miR-17-92 deficiency reduced TH17 differentiation and ameliorated experimental autoimmune encephalomyelitis (EAE) symptoms. -genetics_knock down_suppress hsa-mir-155 Encephalomyelitis 24648472 MiR-155 (-/-) mice are highly resistant to experimental autoimmune encephalomyelitis (EAE) -genetics_knock down_suppress hsa-mir-18a Prostate Neoplasms 24752237 "Interestingly, miR-18a knockdown decreased cell growth in prostate cancer cells and significantly decreased prostate tumor growth in in vivo nude mice experiments through STK4-mediated dephosphorylation of AKT and thereby inducing apoptosis." -genetics_knock down_suppress hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 24804226 Silencing miR-21 sensitizes non-small cell lung cancer A549 cells to ionizing radiation through inhibition of PI3K/Akt. -genetics_knock down_suppress hsa-mir-182 Ovarian Neoplasms 24825857 "we found that anti-miR182 treatment can significantly reduce tumor burden (size), local invasion, and distant metastasis compared with its control in both models." -genetics_knock down_suppress hsa-mir-17 Medulloblastoma 24928431 "Remarkably, deletion of the miR-17âˆ?2 cluster abolished the development of SHH-MB in Ptch1(+/-) mice." -genetics_knock down_suppress hsa-mir-92a Myocardial Ischemic-Reperfusion Injury 24941323 Inhibiting miR-92a can attenuate myocardiocyte apoptosis induced by hypoxia/reoxygenation by targeting Smad7. -genetics_knock down_suppress hsa-mir-221 "Carcinoma, Hepatocellular" 24993451 Bioinformatics analysis identifies miR-221 as a core regulator in hepatocellular carcinoma and its silencing suppresses tumor properties. -genetics_knock down_suppress hsa-mir-145 Atherosclerosis 25008143 Absence of miR-143/145 significantly reduced atherosclerotic plaque size and macrophage infiltration. -genetics_knock down_suppress hsa-mir-21 Lung Neoplasms 25065740 "PHF8 promotes miR-21 expression in human lung cancer, and miR-21 knockdown blocks the effects of PHF8 on proliferation and apoptosis of lung cancer cells." -genetics_knock down_suppress hsa-mir-21 Obesity 25141837 "MiR-21 inhibition reduced body weight, as well as adipocyte size and serum triglycerides were significantly decreased." -genetics_knock down_suppress hsa-mir-17 "Leukemia, Lymphocytic, Chronic, B-Cell" 25339346 In-vitro administration of antagomiR17 effectively reduced miR-17 expression and the proliferation of CLL-like MEC-1 cells. -genetics_knock down_suppress hsa-mir-21 Vascular Disease [unspecific] 25360215 "Low expression of miR-21 significantly inhibited VSMC proliferation, invasion and migration." -genetics_knock down_suppress hsa-mir-21 "Leukemia, Lymphoblastic, Acute" 25451263 "Transient inhibition of miR-21 resulted in increased apoptosis, PTEN upregulation and AKT dephosphorylation, whereas ectopic overexpression of miR-21 further conferred imatinib resistance." -genetics_knock down_suppress hsa-mir-19b "Carcinoma, Embryonal" 25483911 The results demonstrated that miR-19b knockdown inhibited the proliferation and apoptosis of P19 cells. -genetics_knock down_suppress hsa-let-7c Heart Failure 25505600 "Let-7c inhibitor prevented the deterioration of cardiac function postinfarction, as demonstrated by preserved LV ejection fraction and elevated cardiac output." -genetics_knock down_suppress hsa-mir-155 Neoplasms [unspecific] 25598954 the proper increase of miR-155 inhibitor concentration can inhibit miR-155 and consequently increase caspase-3 activity and induce apoptosis in the Jurkat cells leading to cell death ultimately. -genetics_knock down_suppress hsa-mir-17 "Leukemia, Myeloid, Chronic" 25647305 "Furthermore, overexpression of c-Myc or miR-17/20a alleviated NC induced differentiation and apoptosis in K562 cells." -genetics_knock down_suppress hsa-mir-20a "Leukemia, Myeloid, Chronic" 25647305 "Furthermore, overexpression of c-Myc or miR-17/20a alleviated NC induced differentiation and apoptosis in K562 cells." -genetics_knock down_suppress hsa-mir-155 Spinal Cord Injuries 25651871 Mir-155 deficiency suppresses Th17 cell differentiation and improves locomotor recovery after SCI. -genetics_knock down_suppress hsa-let-7b Neoplasms [unspecific] 25682900 "our findings suggest that let-7b contributes to the fidelity of cell division via regulation of Aurora B. Moreover, the loss of let-7b in aggressive tumors may drive tumorigenesis by up-regulation of Aurora B and other targets of the miRNA, which further supports the role of let-7b in tumor suppression." -genetics_knock down_suppress hsa-mir-21 Cholangiocarcinoma 25769721 anti-miR-21 treatment reduced liver tumor growth and prevented tumor development. -genetics_knock down_suppress hsa-mir-122 Hepatitis C Virus Infection 25848473 "miR-122 promotes HCV accumulation, inhibition of miR-122 has been shown as an effective therapy for the treatment of HCV infection in both chimpanzees and humans." -genetics_knock down_suppress hsa-mir-221 Rheumatoid Arthritis 25891943 Downregulation of miR-221 significantly suppressed the expression of pro-inflammatory cytokines and the chemokine -genetics_knock down_suppress hsa-mir-31 Myocardial Infarction 25925791 miR-31 downregulation alleviated myocardial infarct size in vivo. -genetics_knock down_suppress hsa-mir-208a Myocardial Infarction 25936493 Overexpression of antagomir-208a and pretreatment with atorvastatin and valsartan in the AMI group significantly decreased the area of myocardial fibrosis induced by infarction. -genetics_knock down_suppress hsa-mir-21 Glioblastoma 25991676 Both MPS1 and miR-21 depletion suppressed GBM cell proliferation -genetics_knock down_suppress hsa-mir-195 Diabetic Cardiomyopathies 25994075 Therapeutic silencing of miR-195 reduces myocardial hypertrophy and improves coronary blood flow and myocardial function in diabetes -genetics_knock down_suppress hsa-mir-21 Colorectal Carcinoma 25994220 "miR-21-knockout mice showed reduced expression of proinflammatory and procarcinogenic cytokines (interleukin (IL) 6, IL-23, IL-17A and IL-21) and a decrease in the size and number of tumours compared with the control mouse group." -genetics_knock down_suppress hsa-let-7 Neoplasms [unspecific] 26033159 "we found that expression of DICER1 hotspot mutants promoted cell proliferation, whereas wild-type (WT) DICER1 inhibited cell proliferation. Furthermore, targets of let-7 family miRNAs are enriched among the up-regulated genes, suggesting that loss of let-7 may be impacting downstream pathways. Our results reveal that DICER1 hotspot mutations are implicated in common malignancies and may constitute a unique oncogenic pathway." -genetics_knock down_suppress hsa-mir-34a Myocardial Infarction 26082557 locked nucleic acid-based anti-miR-34a treatment diminished post-MI miR-34a upregulation in adult hearts and significantly improved post-MI remodeling. -genetics_knock down_suppress hsa-mir-150 Myocardial Infarction 26109086 MicroRNA-150 deletion in mice protects kidney from myocardial infarction-induced acute kidney injury. -genetics_knock down_suppress hsa-mir-214 Liver Fibrosis 26122702 Pdgf-c Tg mice treated with LNA-antimiR-214 showed a marked reduction in fibrosis and tumor incidence compared with saline or LNA-miR-control-injected control mice. -genetics_knock down_suppress hsa-mir-17 Graft-Versus-Host Disease 26138686 "Furthermore, we evaluated a translational approach and found that systemic administration of antagomir to block miR-17 or miR-19b in this cluster significantly inhibited alloreactive T-cell expansion and interferon-γ (IFNγ) production, and prolonged" -genetics_knock down_suppress hsa-mir-19b Graft-Versus-Host Disease 26138686 systemic administration of antagomir to block miR-17 or miR-19b in this cluster significantly inhibited alloreactive T-cell expansion and interferon-γ (IFNγ) production -genetics_knock down_suppress hsa-mir-372 "Adenocarcinoma, Gastric" 26151747 "Subcutaneously delivered LNAs reduce tumor growth of AGS xenografts in mice, upon formation of a stable, specific heteroduplex with the targeted miR-372 and -373 and LATS2 upregulation." -genetics_knock down_suppress hsa-mir-150 Liver Injury 26196694 miR-150 deficiency prevents Fas-induced hepatocyte apoptosis and liver injury through regulation of the Akt pathway. -genetics_knock down_suppress hsa-mir-181a Ischemic Diseases [unspecific] 26283227 "Delivery of anti-miR-181a, which neutralizes endogenous miR-181a, significantly attenuated H2O2-induced decrease of HKII expression and disruption of mitochondrial membrane potential, improving the survival of MSCs exposed to H2O2." -genetics_knock down_suppress hsa-mir-31 "Squamous Cell Carcinoma, Esophageal" 26286729 anti-miR-31 reduced miR-31 overexpression (P = .002) and suppressed the esophageal preneoplasia in Zn-deficient rats. -genetics_knock down_suppress hsa-mir-214 "Adenocarcinoma, Lung" 26299367 "downregulation of miR-214 expression in CSLCs resulted in a significant decrease in spheroid formation and the expression of the stem-cell markers Nanog, Oct-4, and Sox-2." -genetics_knock down_suppress hsa-mir-21 "Fatty Liver, Non-Alcoholic" 26338827 "MicroRNA-21 inhibition or suppression decreases liver injury, inflammation and fibrosis" -genetics_knock down_suppress hsa-mir-155 Stroke 26354913 In Vivo Inhibition of miR-155 Promotes Recovery after Experimental Mouse Stroke. -genetics_knock down_suppress hsa-mir-20a "Carcinoma, Lung, Non-Small-Cell" 26356817 Stable knock down of miR-20a increases TβRII expression and inhibits tumorigenicity of lung cancer cells in vivo. -genetics_knock down_suppress hsa-mir-205 Neoplasms [unspecific] 26446417 "When HEC-50B cells and HEC-1-A cells were treated with anti-miR-205 inhibitor, the migration and invasion were decreased as compared with the negative control." -genetics_knock down_suppress hsa-mir-222 Pancreatic Neoplasms 26535064 "we co-transfected miR-222 inhibitor and p57 si-RNA into Capan-2 cells, and found that proliferation-suppressing effects of miR-222 inhibitor on Capan-2 cells could be partially reversed by silencing p57." -genetics_knock down_suppress hsa-mir-192 "Adenocarcinoma, Lung" 26550150 MiR-192 inhibitor treated tumor exhibits sensitivity to cisplatin and gemcitabine therapy. -genetics_knock down_suppress hsa-mir-503 "Carcinoma, Esophageal" 26580839 The specific inhibition of miR-503 expression remarkably suppressed proliferation and invasion of tumor cells. -genetics_knock down_suppress hsa-mir-96 Bladder Neoplasms 26582573 the inhibition of miR-96 expression remarkably decreased cell proliferation and promoted cell apoptosis of BC cell lines -genetics_knock down_suppress hsa-mir-155 Acute Myocardial Infarction 26589288 "We reveal that in vivo, miR-155 knockout improves left ventricular function, reduces infarct size, and attenuates collagen deposition, whereas overexpression of miR-155 produces the opposite effects." -genetics_knock down_suppress hsa-mir-106b "Carcinoma, Renal Cell" 26648244 Downregulation of miR-106b with a synthesized inhibitor suppressed cell migration and proliferation and induced renal cancer cell apoptosis -genetics_knock down_suppress hsa-mir-208a Myocardial Infarction 26688617 "Therapeutic inhibition of miR-208a decreased cardiac fibrosis, hypertrophy, and apoptosis and significantly improved cardiac function 28 days after MI." -genetics_knock down_suppress hsa-mir-210 Nervous System Diseases [unspecific] 26708520 "Application of miR-210 inhibitor efficiently downregulated endogenous miR-210, protected apoptosis and neurite retraction in bupivacaine damaged DRG neurons." -genetics_knock down_suppress hsa-mir-184 "Adenocarcinoma, Pancreatic Ductal" 26722418 "The transfection of inhibitor effectively suppressed the expression of miR-184, and further inhibited both cell proliferation and invasion abilities, in addition to the up-regulation of pro-apoptotic protein caspase 3 expression." -genetics_knock down_suppress hsa-mir-630 Ovarian Neoplasms 26725326 Treatment with the combination of anti-miR-630 and anti-vascular endothelial growth factor antibody in mice resulted in rescue of Dicer expression and significantly decreased tumor growth and metastasis. -genetics_knock down_suppress hsa-mir-15b Colorectal Carcinoma 26743779 "Inhibition of miR-15b activity by adenovirus carrying antimiR-15b sequence significantly increased MTSS1 and Klotho protein expression and subsequently decreased colony formation ability, invasion, and migration of HCT116 cells in vitro and liver metastasis of HCT116 tumors in vivo." -genetics_knock down_suppress hsa-mir-193 Gastric Neoplasms 26753960 "In AGS and MKN-45 cells, miR-193-3p downregulation reduced cancer proliferation, migration and 5-FU chemoresistance in vitro, and tumorigenicity in vivo." -genetics_knock down_suppress hsa-mir-126 Myocardial Infarction 26782549 miR-126 is down-regulated in myocardial ischemia-reperfusion injury and that the inhibition of miR-126 may protect against myocardial cell apoptosis caused by ischemia-reperfusion. -genetics_knock down_suppress hsa-mir-223 Encephalomyelitis 26783338 We demonstrate that miR-223-knockout mice display significantly reduced active and adoptive-transfer experimental autoimmune encephalomyelitis -genetics_knock down_suppress hsa-mir-125b Amyotrophic Lateral Sclerosis 26794445 "by restoring A20 levels, miR-125b inhibition then sustains motor neuron survival." -genetics_knock down_suppress hsa-mir-210 Myocardial Infarction 26807177 Inhibition of miR-210 expression improved the survival and cardiac function of MI mice. -genetics_knock down_suppress hsa-mir-130b "Carcinoma, Hepatocellular" 26861561 knockdown or overexpression of miR-130b inhibited and promoted proliferation and metastasis of HCC cells -genetics_knock down_suppress hsa-mir-21 Myocardial Ischemic-Reperfusion Injury 26862785 recombinant HMGB1-box treatment protects against I/R injury and the mechanisms may involve inhibition of miR-21 expression. -genetics_knock down_suppress hsa-mir-183 Pancreatic Adenocarcinoma 26870180 miR-183 knockdown decreased cell growth and motility in pancreatic cancer cells and significantly increased the expression of SOCS-6. -genetics_knock down_suppress hsa-mir-146b "Carcinoma, Thyroid, Papillary" 26883911 miR-146b-5p positively regulates migration and invasion of thyroid normal and tumor follicular cells -genetics_knock down_suppress hsa-mir-222 Neoplasms [unspecific] 26909602 "Anti-miR-222 inhibitor treatment decreased cell proliferation, migration, tube formation, and induced apoptosis." -genetics_knock down_suppress hsa-mir-199a Pancreatic Neoplasms 26918939 "Inhibition of miR-199a/-214 using hairpin inhibitors significantly inhibited TGFβ-induced differentiation markers (e.g. α-SMA, collagen, PDGFβR), migration and proliferation." -genetics_knock down_suppress hsa-mir-34a Cholangiocarcinoma 26923637 "The inhibition of miR-34a decreased proliferation, migration and invasion in cholangiocarcinoma cells." -genetics_knock down_suppress hsa-mir-125b Melanoma 26968260 inhibition of miR-125b reduces migratory and invasive potentials without affecting cell proliferation in vitro. -genetics_knock down_suppress hsa-mir-21 Ischemia-Reperfusion Injury 27030384 "With downregulation of miR-21, the protection of delayed IPC was attenuated and PHD2 protein was increased." -genetics_knock down_suppress hsa-mir-223 Multiple Sclerosis 27083389 "miR223 promotes EAE, probably through enhancing DC activation and subsequently the differentiation of naive T cells toward Th1 and Th17 effector cells." -genetics_knock down_suppress hsa-mir-25 Choriocarcinoma 27120728 Inhibition of miR-25 by its sponge in AGS cells resulted in suppressed cell viability (P<0.01) and promoted cell apoptosis (P<0.01) -genetics_knock down_suppress hsa-mir-192 Liver Injury 27129188 "Functional experiments confirmed a protective effect of down-regulation of miR-192-5p in hepatocytes, suggesting a role of miR-192-5p in limiting liver injury." -genetics_knock down_suppress hsa-mir-23b "Carcinoma, Nasopharyngeal" 27150436 "inhibition of miRâ€?3b could significantly suppress NPC cell proliferation, migration and invasion." -genetics_knock down_suppress hsa-mir-128 Myocardial Ischemic-Reperfusion Injury 27150726 miRâ€?28 antagomirs significantly reduced apoptosis in hearts subjected to I/R injury -genetics_knock down_suppress hsa-mir-125b "Leukemia, Myeloid, Chronic" 27158338 inhibition of miR-125b decreased the proliferation rates and promoted apoptosis with cell cycle arrest at the G0/G1 phase in both K562 and NB-4 cells -genetics_knock down_suppress hsa-mir-451 "Leukemia, Myeloid, Chronic" 27158338 inhibition of miR-125b decreased the proliferation rates and promoted apoptosis with cell cycle arrest at the G0/G1 phase in both K562 and NB-4 cells -genetics_knock down_suppress hsa-mir-224 Cerebral Ischemia 27165196 miR-224 inhibitor reduced neuronal cell apoptosis -genetics_knock down_suppress hsa-mir-544a Colorectal Carcinoma 27165435 miR-544a inhibitor and/or HOXA10 overexpression reduced lung metastases in HCT116 xenografts. -genetics_knock down_suppress hsa-mir-592 Colorectal Carcinoma 27167185 "miR-592 inhibitor exhibited a significant reduction of migration, proliferation, and clonogenicity in CRC cells." -genetics_knock down_suppress hsa-mir-21 Esophageal Neoplasms 27188433 "the proliferation, migration, and invasion of TE11 cells were less active in Inhibition-miR21 group." -genetics_knock down_suppress hsa-mir-138 Intervertebral Disc Degeneration 27207584 "inhibition of miR-138-5p downregulated PTEN protein expression and promoted activation of PI3K/AKT, and knockdown of either SIRT1 or the PI3K/Akt inhibitor (LY294002) abolished the effect of miR-138-5p on NP cell apoptosis." -genetics_knock down_suppress hsa-mir-27b "Carcinoma, Lung, Non-Small-Cell" 27221512 introduction of miRâ€?7b inhibitors significantly induced apoptosis and inhibited the proliferation of A549 cells. -genetics_knock down_suppress hsa-mir-21 Liver Cirrhosis 27226339 Ad-TuD-21 administered to liver fibrosis rats could remarkably suppress profibrotic gene expression -genetics_knock down_suppress hsa-mir-455 "Squamous Cell Carcinoma, Oral" 27235675 MiR-455-5p knockdown reduced both the anchorage-independent growth and the proliferative ability of oral cancer cells -genetics_knock down_suppress hsa-mir-454 "Carcinoma, Lung, Non-Small-Cell" 27261580 "Down-regulation of miR-454 could significantly reduce NSCLC cell proliferation, enhance cell apoptosis, and impair cell invasion and migration in vitro, while up-regulation of miR-454 showed opposite effects." -genetics_knock down_suppress hsa-mir-93 Cervical Neoplasms 27279231 Enforced miR-93 knockdown or RAB11FIP1 overexpression suppressed proliferation and promoted apoptosis -genetics_knock down_suppress hsa-mir-206 Mycobacterium tuberculosis Infection 27291149 Inhibition of miR-206 markedly suppressed inflammatory cytokine secretion -genetics_knock down_suppress hsa-mir-155 Graft-Versus-Host Disease 27296836 miR-155-/- mice showed resistance to cardiac rejection along with weakened T-cell-mediated inflammation -genetics_knock down_suppress hsa-mir-224 Gastric Neoplasms 27315344 "inhibition of miR-224 significantly reduced the expression of mTOR and improved caspase-9/3 expression while decreased cyclin D1/2 levels, attenuating gastric cancer cell proliferation." -genetics_knock down_suppress hsa-mir-214 Breast Neoplasms 27328731 "Depleting miR-214 or elevating miR-148b blocked the dissemination of melanoma or breast cancer cells, an effect that could be accentuated by dual alteration." -genetics_knock down_suppress hsa-mir-214 Melanoma 27328731 "Depleting miR-214 or elevating miR-148b blocked the dissemination of melanoma or breast cancer cells, an effect that could be accentuated by dual alteration." -genetics_knock down_suppress hsa-mir-154 Glioblastoma 27338789 Knockdown of miR-154 remarkably suppressed proliferation and migration of CD133(+) GBM cells. -genetics_knock down_suppress hsa-mir-24 "Squamous Cell Carcinoma, Tongue" 27350307 "Inhibition of miR-24 significantly suppressed the proliferation, migration and invasion of TSCC cells in vitro." -genetics_knock down_suppress hsa-mir-21 Colorectal Adenocarcinoma 27364574 Locked nucleic acid anti-miR-21 inhibits cell growth and invasive behaviors of a colorectal adenocarcinoma cell line -genetics_knock down_suppress hsa-mir-155 Acute Lung Injury 27371731 miR-155 gene inactivation protected mice from LPS-induced ALI -genetics_knock down_suppress hsa-mir-181a "Carcinoma, Hepatocellular" 27384977 "Exogenous miR-181a expression in HepG2 cells reduced apoptosis, whereas inhibition of miR-181a in Hpe3B cells increased apoptosis." -genetics_knock down_suppress hsa-mir-9 "Carcinoma, Breast, Triple Negative" 27402080 "miR-9 and miR-200 promoted and inhibited, respectively, the formation of vascular-like structures in vitro" -genetics_knock down_suppress hsa-mir-23a Macular Degeneration 27411920 Inhibition of the H2O2-induced miR-23a by antagomiR protected the RPE cells from the oxidative stress-induced cell death. -genetics_knock down_suppress hsa-mir-18a "Adenocarcinoma, Lung" 27412935 Downregulation of miR-18a or miR-328 can inhibit the invasion and migration abilities of A549 cells effectively. -genetics_knock down_suppress hsa-mir-328 "Adenocarcinoma, Lung" 27412935 Downregulation of miR-18a or miR-328 can inhibit the invasion and migration abilities of A549 cells effectively. -genetics_knock down_suppress hsa-mir-200a Breast Neoplasms 27433802 "We further showed that inhibition of miR-200a function, mimicking the effect of calorie restriction on this microRNA, inhibited proliferation in both rat (LA7) and human (MCF7) luminal mammary cancer cell lines." -genetics_knock down_suppress hsa-mir-942 Kaposi Sarcoma 27440900 "Suppression of miR-942-5p relieved I¦ÊB¦Á expression and reduced Vpr inhibition of KSHV replication, while overexpression of miR-942-5p enhanced Vpr inhibition of KSHV replication." -genetics_knock down_suppress hsa-mir-10b Endometrial Neoplasms 27447302 "The silence of miR-10b resulted in significantly enhanced cell apoptosis, and remarkably reduced cell proliferation, migration, and invasion (pâ€?â€?.05)." -genetics_knock down_suppress hsa-mir-9 Prostate Neoplasms 27447934 "Inhibition of miR-9 resulted in reduced migratory and invasive potential of the M12 cell line, and reduced tumour growth and metastases in male athymic nude mice." -genetics_knock down_suppress hsa-mir-21 Asthma 27448447 "Treatment with Ant-21, or the pan-PI3K inhibitor LY294002, reduced PI3K activity and restored HDAC2 levels. This led to suppression of airway hyperresponsiveness and restored steroid sensitivity to allergic airway disease." -genetics_knock down_suppress hsa-mir-106b Pituitary Neoplasms 27465551 "Down-regulation of miR-106b or up-regulation of PTEN could suppress cell proliferation and invasion of AtT-20 cells, and PTEN expression plasmid could partially simulate the function of miR-106b." -genetics_knock down_suppress hsa-mir-155 "Carcinoma, Cervical" 27470551 "Moreover, knockdown of miR-155 was demonstrated to inhibit cell proliferation, migration, and invasion in vitro." -genetics_knock down_suppress hsa-mir-210 Epilepsy 27471387 Our data showed that morphological changes of hippocampal neurons and apoptosis triggered by epilepsy were mitigated by miR-210 inhibition. -genetics_knock down_suppress hsa-mir-182 "Carcinoma, Breast, Triple Negative" 27476169 Knockdown of miR-182 promotes apoptosis via regulating RIP1 deubiquitination in TNF-α-treated triple-negative breast cancer cells. -genetics_knock down_suppress hsa-mir-137 Vascular Injuries 27497953 "Down-regulation of miR-137 ameliorates HG-induced injury in HUVECs by overexpression of AMPKα1, leading to increasing cellular reductive reactions and decreasing oxidative stress." -genetics_knock down_suppress hsa-mir-17 Lymphoma 27498867 "Loss of miR-17/92 in Myc(+) tumor cells leads to a global decrease in tumor cell metabolism, affecting both glycolytic and mitochondrial metabolism, whereas increased miR-17/92 expression is sufficient to drive increased nutrient usage by tumor cells." -genetics_knock down_suppress hsa-mir-126 "Carcinoma, Hepatocellular" 27499630 Inhibition of miR-126 expression increased Spred1 expression and decreased vascular endothelial growth factor expression (P<0.01). -genetics_knock down_suppress hsa-mir-346 "Carcinoma, Nasopharyngeal" 27501413 Inhibition of miR-346 significantly attenuated the migration and invasion of NPC cells. -genetics_knock down_suppress hsa-mir-106a "Carcinoma, Ovarian" 27510094 Downregulation of the expression of miR-106a inhibited cell growth and metastasis of ovarian cancer cells. -genetics_knock down_suppress hsa-mir-24 "Squamous Cell Carcinoma, Head and Neck" 27513190 "Inhibition of miR-24-3p reduced cell proliferation, colony formation efficiency and reversed chemoresistance in HNSCC cells." -genetics_knock down_suppress hsa-mir-21 Osteosarcoma 27513462 microRNA-21 inhibition slowed proliferation and exogenously expressed microRNA-21 promoted this process. -genetics_knock down_suppress hsa-mir-106b "Carcinoma, Breast" 27519168 "down-regulation of miR-106b increased the expression of FUT6 and resulted in an obvious decrease of cell migration, invasion, and proliferation in MDA-MB-231 cells." -genetics_knock down_suppress hsa-mir-127 Obesity 27532680 "On the other hand, locked nucleic acid inhibitor synthesized to target miR-127-5p significantly increased b-F1-ATPase translation efficiency in myotubes." -genetics_knock down_suppress hsa-mir-21 Melanoma 27533779 "MiR-21 can promote the proliferation, migration, and inhibit the apoptosis of human melanoma A375 cells by inhibiting SPRY1, PDCD4, and PTEN via ERK/NF-kB signaling pathway." -genetics_knock down_suppress hsa-mir-181a "Carcinoma, Cervical" 27534652 Inhibition of microRNA-181a may suppress proliferation and invasion and promote apoptosis of cervical cancer cells through the PTEN/Akt/FOXO1 pathway. -genetics_knock down_suppress hsa-mir-21 Liver Cirrhosis 27775690 Knockout of microRNA-21 reduces biliary hyperplasia and liver fibrosis in cholestatic bile duct ligated mice. -genetics_knock down_suppress hsa-mir-322 "Carcinoma, Breast" 28404630 miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy. -genetics_knock down_suppress hsa-mir-424 "Carcinoma, Breast" 28404630 miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy. -genetics_knock down_suppress hsa-mir-503 "Carcinoma, Breast" 28404630 miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy. -genetics_knock down_suppress hsa-mir-27a Colorectal Carcinoma 28423356 Knockdown of miR-27a sensitizes colorectal cancer stem cells to TRAIL by promoting the formation of Apaf-1-caspase-9 complex. -genetics_knock down_suppress hsa-mir-155 Infection [unspecific] 28804270 Knockdown of miR-155 protects microglia against LPS-induced inflammatory injury via targeting RACK1: a novel research for intracranial infection -genetics_knock down_suppress hsa-mir-29a "Carcinoma, Breast" 29021023 Knockdown of microRNA-29a Changes the Expression of Heat Shock Proteins in Breast Carcinoma MCF-7 Cells. -genetics_knock down_suppress hsa-mir-29a "Carcinoma, Breast" 29435304 Knockdown of microRNA-29a regulates the expression of apoptosis-related genes in MCF-7 breast carcinoma cells -genetics_knock down_suppress hsa-mir-21 Neoplasms [unspecific] 29540832 miR-21 depletion in macrophages promotes tumoricidal polarization and enhances PD-1 immunotherapy -genetics_knock down_suppress hsa-mir-146a Listeriosis 29587465 MicroRNA-146a Deficiency Protects against Listeria monocytogenes Infection by Modulating the Gut Microbiota -genetics_knock down_suppress hsa-mir-21 Colitis 29608690 Loss of microRNA-21 Influences the Gut Microbiota Causing Reduced Susceptibility in a Murine Model of Colitis -genetics_knock down_suppress hsa-mir-21 Alcoholic Hepatitis 29848019 Knockout of microRNA-21 attenuates alcoholic hepatitis through the VHL/NF-¦ÊB signaling pathway in hepatic stellate cells. -genetics_knock down_suppress hsa-mir-1246 "Carcinoma, Cervical" 30078258 Lentivirus media miR-1246 knockdown inhibits tumor growth and promotes apoptosis of SiHa cells -genetics_knock down_suppress hsa-mir-299 "Carcinoma, Hepatocellular" 30266288 Knockdown of miR-299-5p inhibits the progression of hepatocellular carcinoma by targeting SIAH1. -genetics_overexpression_promote hsa-mir-17 Lymphoma 16940181 "Mir-17-5p, also known as Mir-91,is located on chromosome 13q31; this gene is amplified in childhoodlymphoma." -genetics_overexpression_promote hsa-mir-17 Hematologic Neoplasms 17011485 The miR-17-92 cluster is amplified in hematopoietic malignancies. -genetics_overexpression_promote hsa-mir-18a Hematologic Neoplasms 17011485 The miR-17-92 cluster is amplified in hematopoietic malignancies. -genetics_overexpression_promote hsa-mir-19a Hematologic Neoplasms 17011485 The miR-17-92 cluster is amplified in hematopoietic malignancies. -genetics_overexpression_promote hsa-mir-19b-1 Hematologic Neoplasms 17011485 The miR-17-92 cluster is amplified in hematopoietic malignancies. -genetics_overexpression_promote hsa-mir-20a Hematologic Neoplasms 17011485 The miR-17-92 cluster is amplified in hematopoietic malignancies. -genetics_overexpression_promote hsa-mir-17 Colon Neoplasms 17965831 "The miRNA cluster miR-17-92 is located at 13q31.3 and has been associated with several types of cancer, including colorectal cancer and lung cancer, and is thought to be a potential oncogene [86, 87] that enhances cell proliferation." -genetics_overexpression_promote hsa-mir-17 Lung Neoplasms 17965831 "The miRNA cluster miR-17-92 is located at 13q31.3 and has been associated with several types of cancer, including colorectal cancer and lung cancer, and is thought to be a potential oncogene [86, 87] that enhances cell proliferation." -genetics_overexpression_promote hsa-mir-18a Colon Neoplasms 17965831 "The miRNA cluster miR-17-92 is located at 13q31.3 and has been associated with several types of cancer, including colorectal cancer and lung cancer, and is thought to be a potential oncogene [86, 87] that enhances cell proliferation." -genetics_overexpression_promote hsa-mir-18a Lung Neoplasms 17965831 "The miRNA cluster miR-17-92 is located at 13q31.3 and has been associated with several types of cancer, including colorectal cancer and lung cancer, and is thought to be a potential oncogene [86, 87] that enhances cell proliferation." -genetics_overexpression_promote hsa-mir-19a Colon Neoplasms 17965831 "The miRNA cluster miR-17-92 is located at 13q31.3 and has been associated with several types of cancer, including colorectal cancer and lung cancer, and is thought to be a potential oncogene [86, 87] that enhances cell proliferation." -genetics_overexpression_promote hsa-mir-19a Lung Neoplasms 17965831 "The miRNA cluster miR-17-92 is located at 13q31.3 and has been associated with several types of cancer, including colorectal cancer and lung cancer, and is thought to be a potential oncogene [86, 87] that enhances cell proliferation." -genetics_overexpression_promote hsa-mir-19b-1 Colon Neoplasms 17965831 "The miRNA cluster miR-17-92 is located at 13q31.3 and has been associated with several types of cancer, including colorectal cancer and lung cancer, and is thought to be a potential oncogene [86, 87] that enhances cell proliferation." -genetics_overexpression_promote hsa-mir-19b-1 Lung Neoplasms 17965831 "The miRNA cluster miR-17-92 is located at 13q31.3 and has been associated with several types of cancer, including colorectal cancer and lung cancer, and is thought to be a potential oncogene [86, 87] that enhances cell proliferation." -genetics_overexpression_promote hsa-mir-20a Colon Neoplasms 17965831 "The miRNA cluster miR-17-92 is located at 13q31.3 and has been associated with several types of cancer, including colorectal cancer and lung cancer, and is thought to be a potential oncogene [86, 87] that enhances cell proliferation." -genetics_overexpression_promote hsa-mir-20a Lung Neoplasms 17965831 "The miRNA cluster miR-17-92 is located at 13q31.3 and has been associated with several types of cancer, including colorectal cancer and lung cancer, and is thought to be a potential oncogene [86, 87] that enhances cell proliferation." -genetics_overexpression_promote hsa-mir-92a-1 Colon Neoplasms 17965831 "The miRNA cluster miR-17-92 is located at 13q31.3 and has been associated with several types of cancer, including colorectal cancer and lung cancer, and is thought to be a potential oncogene [86, 87] that enhances cell proliferation." -genetics_overexpression_promote hsa-mir-92a-1 Lung Neoplasms 17965831 "The miRNA cluster miR-17-92 is located at 13q31.3 and has been associated with several types of cancer, including colorectal cancer and lung cancer, and is thought to be a potential oncogene [86, 87] that enhances cell proliferation." -genetics_overexpression_promote hsa-let-7g "Carcinoma, Lung, Non-Small-Cell" 18308936 we observed significant growth reduction of both murine and human non-small cell lung tumors when overexpression of let-7g was induced from lentiviral vectors -genetics_overexpression_promote hsa-mir-184 Squamous Cell Carcinoma 18451220 "Overexpression of miR-184 might play an oncogenic role in the antiapoptotic and proliferative processes of tongue SCC. In addition, plasma miR-184 levels were associated with the presence of primary tumor. " -genetics_overexpression_promote hsa-mir-221 Prostate Neoplasms 19107213 miR-221: The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice -genetics_overexpression_promote hsa-mir-222 Prostate Neoplasms 19107213 miR-222: The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice -genetics_overexpression_promote hsa-mir-31 Leiomyosarcoma 19602040 overexpression; leads to HMGA2 overexpression; Disrupting the control of HMGA2 and let-7 pairs promotes ULMS cell growth in vitro. -genetics_overexpression_promote hsa-mir-125a Ovarian Neoplasms 19881956 Overexpression of miR-125a induces conversion of highly invasive ovarian cancer cells -genetics_overexpression_promote hsa-mir-26a Glioblastoma 20080666 "Overexpression of miR-26a in PTEN-competent and PTEN-deficient glioblastoma cells promoted tumor growth in vivo, and it further increased growth in cells overexpressing CDK4 or CENTG1." -genetics_overexpression_promote hsa-mir-17 Neoplasms [unspecific] 20439436 mir-17:We correctly identified hsa-miR-17/92 family as amplified and the hsa-miR-143/145 cluster as deleted -genetics_overexpression_promote hsa-mir-18a Neoplasms [unspecific] 20439436 mir-18a:We correctly identified hsa-miR-17/92 family as amplified and the hsa-miR-143/145 cluster as deleted -genetics_overexpression_promote hsa-mir-19a Neoplasms [unspecific] 20439436 mir-19a:We correctly identified hsa-miR-17/92 family as amplified and the hsa-miR-143/145 cluster as deleted -genetics_overexpression_promote hsa-mir-19b-1 Neoplasms [unspecific] 20439436 mir-19b:We correctly identified hsa-miR-17/92 family as amplified and the hsa-miR-143/145 cluster as deleted -genetics_overexpression_promote hsa-mir-19b-2 Neoplasms [unspecific] 20439436 mir-19b:We correctly identified hsa-miR-17/92 family as amplified and the hsa-miR-143/145 cluster as deleted -genetics_overexpression_promote hsa-mir-92a-1 Neoplasms [unspecific] 20439436 mir-92a:We correctly identified hsa-miR-17/92 family as amplified and the hsa-miR-143/145 cluster as deleted -genetics_overexpression_promote hsa-mir-92a-2 Neoplasms [unspecific] 20439436 mir-92a:We correctly identified hsa-miR-17/92 family as amplified and the hsa-miR-143/145 cluster as deleted -genetics_overexpression_promote hsa-mir-125b Leukemia 21118985 "Thus, we show that overexpression of miR-125b is sufficient both to shorten the latency of BCR-ABL-induced leukemia and to independently induce leukemia in a mouse model." -genetics_overexpression_promote hsa-mir-18a Urinary Bladder Cancer 21388952 Specific deletion of p53 in urothelial cells is associated with specific overexpression of miR-18a and miR-19a and down-regulation of miR-107. -genetics_overexpression_promote hsa-mir-19a Urinary Bladder Cancer 21388952 Specific deletion of p53 in urothelial cells is associated with specific overexpression of miR-18a and miR-19a and down-regulation of miR-107. -genetics_overexpression_promote hsa-mir-155 Hepatitis C Virus Infection 21750860 Coordinated increase of miRNA-155 and miRNA-196b expression correlates with the detection of the antigenomic strand of hepatitis C virus in peripheral blood mononuclear cells. -genetics_overexpression_promote hsa-mir-196b Hepatitis C Virus Infection 21750860 Coordinated increase of miRNA-155 and miRNA-196b expression correlates with the detection of the antigenomic strand of hepatitis C virus in peripheral blood mononuclear cells. -genetics_overexpression_promote hsa-mir-125b-2 Glioblastoma 21879257 miR-125b-2 overexpression might confer glioblastoma stem cells resistance to TMZ. -genetics_overexpression_promote hsa-mir-21 Breast Neoplasms 21917003 High expression of miR-21 in tumor stroma correlates with increased cancer cell proliferation in human breast cancer. -genetics_overexpression_promote hsa-mir-17 "Lymphoma, Burkitt" 21981616 The minimum common amplified region on 13q was at 13q31 and included the MIR17HG (MIR17-92) locus. Samples with this gain had higher levels of MIR17 RNA and showed a tendency for early relapse. -genetics_overexpression_promote hsa-mir-18a "Lymphoma, Burkitt" 21981616 The minimum common amplified region on 13q was at 13q31 and included the MIR17HG (MIR17-92) locus. Samples with this gain had higher levels of MIR17 RNA and showed a tendency for early relapse. -genetics_overexpression_promote hsa-mir-19a "Lymphoma, Burkitt" 21981616 The minimum common amplified region on 13q was at 13q31 and included the MIR17HG (MIR17-92) locus. Samples with this gain had higher levels of MIR17 RNA and showed a tendency for early relapse. -genetics_overexpression_promote hsa-mir-19b-1 "Lymphoma, Burkitt" 21981616 The minimum common amplified region on 13q was at 13q31 and included the MIR17HG (MIR17-92) locus. Samples with this gain had higher levels of MIR17 RNA and showed a tendency for early relapse. -genetics_overexpression_promote hsa-mir-20a "Lymphoma, Burkitt" 21981616 The minimum common amplified region on 13q was at 13q31 and included the MIR17HG (MIR17-92) locus. Samples with this gain had higher levels of MIR17 RNA and showed a tendency for early relapse. -genetics_overexpression_promote hsa-mir-92a-1 "Lymphoma, Burkitt" 21981616 The minimum common amplified region on 13q was at 13q31 and included the MIR17HG (MIR17-92) locus. Samples with this gain had higher levels of MIR17 RNA and showed a tendency for early relapse. -genetics_overexpression_promote hsa-mir-10b Pancreatic Neoplasms 22018284 "MicroRNA-10b is overexpressed in pancreatic cancer, promotes its invasiveness, and correlates with a poor prognosis." -genetics_overexpression_promote hsa-mir-17 Colon Neoplasms 22065543 "MiR-17-92 cluster and its paralogs were significantly overexpressed in colon tumor. No significant associations were found between the deregulation of certain miRNAs and the clinical and pathologic characteristics observed in patients. Kaplan-Meier curves demonstrated significantly reduced overall survival in patients expressing high levels of miR-17. In multivariate Cox models, miR-17 overexpression (HR 2.67; P=0.007) and TNM staging (HR 8.87; P=0.002) were significantly associated with a risk of death." -genetics_overexpression_promote hsa-mir-18a Colon Neoplasms 22065543 "MiR-17-92 cluster and its paralogs were significantly overexpressed in colon tumor. No significant associations were found between the deregulation of certain miRNAs and the clinical and pathologic characteristics observed in patients. Kaplan-Meier curves demonstrated significantly reduced overall survival in patients expressing high levels of miR-17. In multivariate Cox models, miR-17 overexpression (HR 2.67; P=0.007) and TNM staging (HR 8.87; P=0.002) were significantly associated with a risk of death." -genetics_overexpression_promote hsa-mir-19a Colon Neoplasms 22065543 "MiR-17-92 cluster and its paralogs were significantly overexpressed in colon tumor. No significant associations were found between the deregulation of certain miRNAs and the clinical and pathologic characteristics observed in patients. Kaplan-Meier curves demonstrated significantly reduced overall survival in patients expressing high levels of miR-17. In multivariate Cox models, miR-17 overexpression (HR 2.67; P=0.007) and TNM staging (HR 8.87; P=0.002) were significantly associated with a risk of death." -genetics_overexpression_promote hsa-mir-19b-1 Colon Neoplasms 22065543 "MiR-17-92 cluster and its paralogs were significantly overexpressed in colon tumor. No significant associations were found between the deregulation of certain miRNAs and the clinical and pathologic characteristics observed in patients. Kaplan-Meier curves demonstrated significantly reduced overall survival in patients expressing high levels of miR-17. In multivariate Cox models, miR-17 overexpression (HR 2.67; P=0.007) and TNM staging (HR 8.87; P=0.002) were significantly associated with a risk of death." -genetics_overexpression_promote hsa-mir-20a Colon Neoplasms 22065543 "MiR-17-92 cluster and its paralogs were significantly overexpressed in colon tumor. No significant associations were found between the deregulation of certain miRNAs and the clinical and pathologic characteristics observed in patients. Kaplan-Meier curves demonstrated significantly reduced overall survival in patients expressing high levels of miR-17. In multivariate Cox models, miR-17 overexpression (HR 2.67; P=0.007) and TNM staging (HR 8.87; P=0.002) were significantly associated with a risk of death." -genetics_overexpression_promote hsa-mir-92a-1 Colon Neoplasms 22065543 "MiR-17-92 cluster and its paralogs were significantly overexpressed in colon tumor. No significant associations were found between the deregulation of certain miRNAs and the clinical and pathologic characteristics observed in patients. Kaplan-Meier curves demonstrated significantly reduced overall survival in patients expressing high levels of miR-17. In multivariate Cox models, miR-17 overexpression (HR 2.67; P=0.007) and TNM staging (HR 8.87; P=0.002) were significantly associated with a risk of death." -genetics_overexpression_promote hsa-mir-125b-1 Rhinosinusitis 22071331 "Overexpression of miR-125b, a Novel Regulator of Innate Immunity, in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps." -genetics_overexpression_promote hsa-mir-125b-2 Rhinosinusitis 22071331 "Overexpression of miR-125b, a Novel Regulator of Innate Immunity, in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps." -genetics_overexpression_promote hsa-mir-155 "Carcinoma, Hepatocellular" 22071603 Up-regulation of microRNA-155 promotes cancer cell invasion and predicts poor survival of hepatocellular carcinoma following liver transplantation. -genetics_overexpression_promote hsa-mir-223 "Squamous Cell Carcinoma, Esophageal" 22108521 Overexpression of microRNA-223 regulates the ubiquitin ligase FBXW7 in oesophageal squamous cell carcinoma. -genetics_overexpression_promote hsa-mir-124-1 Neuroblastoma 22123030 "Ectopic overexpression of miR-124 resulted in the downregulation of CDK6, decreased cellular proliferation, and induced cellular morphological changes." -genetics_overexpression_promote hsa-mir-124-2 Neuroblastoma 22123030 "Ectopic overexpression of miR-124 resulted in the downregulation of CDK6, decreased cellular proliferation, and induced cellular morphological changes." -genetics_overexpression_promote hsa-mir-124-3 Neuroblastoma 22123030 "Ectopic overexpression of miR-124 resulted in the downregulation of CDK6, decreased cellular proliferation, and induced cellular morphological changes." -genetics_overexpression_promote hsa-mir-122 "Carcinoma, Hepatocellular" 22140464 "miR-122 expression is highly elevated in quiescent human primary hepatocytes (hPHs) but lost or attenuated in hESCs and HCCs, while an opposing expression pattern is observed for Pkm2. Depleting hESCs and HCCs of Pkm2, or overexpressing miR-122, leads to a common deficiency in self-renewal and proliferation." -genetics_overexpression_promote hsa-mir-223 "Leukemia, Lymphocytic, Chronic, B-Cell" 22145958 microRNA-223 expression is uniformly down-regulated in B cell lymphoproliferative disorders and is associated with poor survival in chronic lymphocytic leukemia patients. -genetics_overexpression_promote hsa-mir-200a Prostate Neoplasms 22161972 "miR-200a overexpression reduced prostate cancer cell growth and may have potential, in combination with other markers, in stratifying prostate cancer patients for more intensive monitoring and therapy." -genetics_overexpression_promote hsa-mir-28 Colorectal Carcinoma 22240480 "miR-28-5p altered expression of CCND1 and HOXB3, whereas miR-28-3p bound NM23-H1. Overexpression of miR-28-5p reduced CRC cell proliferation, migration, and invasion in vitro, whereas miR-28-3p increased CRC cell migration and invasion in vitro." -genetics_overexpression_promote hsa-mir-182 Ovarian Neoplasms 22322863 "miR-182 overexpression resulted in increased tumor transformation in vitro, and enhanced tumor invasiveness in vitro and metastasis in vivo. The oncogenic properties of miR-182 in ovarian cancer were mediated in part by its impaired repair of DNA double-strand breaks and negative regulation of breast cancer 1 (BRCA1) and metastasis suppressor 1 (MTSS1) expressions as well as its positive regulation of oncogene high-mobility group AT-hook 2 (HMGA2)." -genetics_overexpression_promote hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 22335905 Overexpression of miR-21 promotes proliferation and reduces apoptosis in non-small cell lung cancer]. -genetics_overexpression_promote hsa-mir-34a Myocardial Infarction 22403243 "IGF-1 significantly inhibited H(2)O(2)-induced miR-34a expression, and miR-34a overexpression abolished the anti-apoptotic effect of IGF-1." -genetics_overexpression_promote hsa-mir-17 Leukemia 22451425 "In both murine and human leukemias, p53 inactivation contributed to the selective overexpression of oncogenic miR-92a and miR-19a, and down-regulation of tumor-suppressive miR-17." -genetics_overexpression_promote hsa-mir-19a Acute Erythroid Leukemia 22451425 "overexpression of individual miRNAs from this locus, miR-19a or miR-92a, results in B-cell hyperplasia and erythroleukemia, respectively." -genetics_overexpression_promote hsa-mir-92a Acute Erythroid Leukemia 22451425 "overexpression of individual miRNAs from this locus, miR-19a or miR-92a, results in B-cell hyperplasia and erythroleukemia, respectively." -genetics_overexpression_promote hsa-mir-130a Ovarian Neoplasms 22455133 The over expression of miR-130a is associated with cisplatin resistance of ovarian cancer. Inhibiting miR-130a expression may help reverse the cisplatin resistance of ovarian cancer. -genetics_overexpression_promote hsa-mir-21 Breast Neoplasms 22547075 DNA damage induces NF-kB-dependent microRNA-21 upregulation and promotes breast cancer cell invasion. -genetics_overexpression_promote hsa-mir-125b "Leukemia, Myeloid, Acute" 22689670 "We previously described a t(2;11)(p21;q23) chromosomal translocation found in patients with myelodysplasia or acute myeloid leukemia that leads to over-expression of the microRNA miR-125b, and we showed that transplantation of mice with murine stem/progenitor cells overexpressing miR-125b is able to induce leukemia." -genetics_overexpression_promote hsa-mir-615 "Carcinoma, Hepatocellular" 22819824 miR-615-5p is restrictedly expressed in cirrhotic and cancerous liver tissues and its overexpression alleviates the tumorigenic effects in hepatocellular carcinoma. -genetics_overexpression_promote hsa-mir-221 Thyroid Neoplasms 22855362 Overexpression of miR-221 is associated with aggressive clinicopathologic characteristics and the BRAF mutation in papillary thyroid carcinomas. -genetics_overexpression_promote hsa-mir-132 Heart Failure 23011132 "MiR-212/132 null mice are protected from pressure-overload-induced heart failure, whereas cardiomyocyte-specific overexpression of the miR-212/132 family leads to pathological cardiac hypertrophy, heart failure and death in mice." -genetics_overexpression_promote hsa-mir-212 Heart Failure 23011132 "MiR-212/132 null mice are protected from pressure-overload-induced heart failure, whereas cardiomyocyte-specific overexpression of the miR-212/132 family leads to pathological cardiac hypertrophy, heart failure and death in mice." -genetics_overexpression_promote hsa-mir-221 Inflammation 23023232 "The overexpression of oncogenic miR-221 and miR-222 caused by HMGB1 is associated with an increase in malignancy scores, namely cell growth and motility." -genetics_overexpression_promote hsa-mir-222 "Carcinoma, Thyroid, Papillary" 23023232 "The overexpression of oncogenic miR-221 and miR-222 caused by HMGB1 is associated with an increase in malignancy scores, namely cell growth and motility." -genetics_overexpression_promote hsa-mir-17 Gastric Neoplasms 23333058 "Overexpression of miR-17-5p/20a promoted gastric cancer cell cycle progression and inhibited cell apoptosis, whereas knockdown of miR-17-5p/20a resulted in cell cycle arrest and increased apoptosis." -genetics_overexpression_promote hsa-mir-20a Gastric Neoplasms 23333058 "Overexpression of miR-17-5p/20a promoted gastric cancer cell cycle progression and inhibited cell apoptosis, whereas knockdown of miR-17-5p/20a resulted in cell cycle arrest and increased apoptosis." -genetics_overexpression_promote hsa-mir-100 "Carcinoma, Renal Cell" 23378187 miR-100 overexpression strongly associates with advanced tumor progression and unfavorable clinical outcome of patients with RCC -genetics_overexpression_promote hsa-mir-106b "Carcinoma, Hepatocellular" 23483935 Over-Expression of miR-106b Promotes Cell Migration and Metastasis in Hepatocellular Carcinoma by Activating Epithelial-Mesenchymal Transition Process -genetics_overexpression_promote hsa-mir-449a "Adenocarcinoma, Lung" 23614048 "Overexpression of miR-449a in CL1-0 cells effectively increased irradiation-induced DNA damage and apoptosis,altered the cell cycle distribution and eventually led to sensitization of CL1-0 to irradiation." -genetics_overexpression_promote hsa-mir-1 Myocardial Infarction 23615185 Overexpression of MicroRNA-1 improves the efficacy of mesenchymal stem cell transplantation after myocardial infarction. -genetics_overexpression_promote hsa-mir-146a Sepsis 23638011 Overexpression of miR-146a induces a state analogous to tolerance in BLP-stimulated cells and therefore may represent a future target for exogenous modulation of tolerance during microbial infection and sepsis. -genetics_overexpression_promote hsa-mir-9 Leukemia 23798388 miR-9 is an essential oncogenic microRNA specifically overexpressed in mixed lineage leukemia-rearranged leukemia. -genetics_overexpression_promote hsa-mir-146b Inflammation 23813877 MicroRNA-146b improves intestinal injury in mouse colitis by activating nuclear factor-¦ÊB and improving epithelial barrier function. -genetics_overexpression_promote hsa-mir-22 Heart Failure 24086656 microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription. -genetics_overexpression_promote hsa-mir-449a Retinoblastoma 24120948 We are the first to confirm an inhibitory effect of miR-449a and -449b in retinoblastoma by demonstrating significantly impaired proliferation and increased apoptosis of tumor cells when these miRNAs are overexpressed. -genetics_overexpression_promote hsa-mir-32 Colorectal Carcinoma 24123284 "MiR-32 overexpression was correlated with specific CRC clinicopathological features and may be a marker of poor prognosis in CRC patients. MiR-32 and PTEN expression were inversely correlated, and miR-32 may be associated with the development of CRC." -genetics_overexpression_promote hsa-mir-17 Leukemia 24145403 "The miR-17?92 overexpression was driven by the E?-enhancer and Ig heavy-chain promoter, and a 3' GFP tag was added to the transgene to track the miR expression." -genetics_overexpression_promote hsa-mir-18a "Leukemia, B-Cell" 24145403 "The miR-17?92 overexpression was driven by the E?-enhancer and Ig heavy-chain promoter, and a 3' GFP tag was added to the transgene to track the miR expression." -genetics_overexpression_promote hsa-mir-19a "Leukemia, B-Cell" 24145403 "The miR-17?92 overexpression was driven by the E?-enhancer and Ig heavy-chain promoter, and a 3' GFP tag was added to the transgene to track the miR expression." -genetics_overexpression_promote hsa-mir-19b "Leukemia, B-Cell" 24145403 "The miR-17?92 overexpression was driven by the E?-enhancer and Ig heavy-chain promoter, and a 3' GFP tag was added to the transgene to track the miR expression." -genetics_overexpression_promote hsa-mir-92a "Leukemia, B-Cell" 24145403 "The miR-17?92 overexpression was driven by the E?-enhancer and Ig heavy-chain promoter, and a 3' GFP tag was added to the transgene to track the miR expression." -genetics_overexpression_promote hsa-mir-21 Colorectal Carcinoma 24149370 "miR-21 is a key player in oncogenic EMT, its overexpression is controlled by the cooperation of genetic and epigenetic alterations, and its levels, along with ITG¦Â4 and PDCD4 expression, could be exploited as a prognostic tool for CRC metastasis." -genetics_overexpression_promote hsa-mir-18a Toxic Epidermal Necrolysis 24184144 Our results indicated that downregulated BCL2L10 caused by miR-18a-5p overexpression mediates intrinsic keratinocyte apoptosis in patients with TEN. Serum miR-18a-5p levels can be a useful disease marker for drug eruptions. -genetics_overexpression_promote hsa-let-7a Systemic Lupus Erythematosus 24240124 our results suggest that overexpression of let-7a may contribute to hyperplasia and the proinflammatory response in SLE. -genetics_overexpression_promote hsa-mir-296 Prostate Neoplasms 24263102 "Interestingly, ectopic expression of miR-296-3p in P69 increases the tolerance to NK cells whereas knockdown of miR-296-3p in M12 reduces the resistance to NK cells, which both phenotypes can be rescued by re-expression or silencing of ICAM-1 in P69 and M12, respectively." -genetics_overexpression_promote hsa-mir-9 Pulmonary Hypertension 24615545 "Knockdown of miR-9 followed by hypoxia exposure attenuated PASMCs proliferation and enhanced the expression of contractile genes in vascular smooth muscle cells (VSMCs), while overexpression of miR-9 in normoxia promoted a proliferative phenotype in PASMCs." -genetics_overexpression_promote hsa-mir-210 Gastrointestinal Stromal Tumor 24623741 "Overexpression of miR-210 is associated with SDH-related pheochromocytomas, paragangliomas, and gastrointestinal stromal tumours." -genetics_overexpression_promote hsa-mir-125a Myelodysplastic Syndromes 24690917 Overexpression of miR-125a in myelodysplastic syndrome CD34+ cells modulates NF-¦ÊB activation and enhances erythroid differentiation arrest. -genetics_overexpression_promote hsa-mir-30c Heart Failure 24789369 Taken together these data indicate impaired mitochondrial function due to OXPHOS protein depletion as a potential cause for the observed dilated cardiomyopathic phenotype in miRNA-30c transgenic mice. -genetics_overexpression_promote hsa-mir-429 Ovarian Neoplasms 24802724 Ectopic over-expression of miR-429 induces mesenchymal-to-epithelial transition (MET) and increased drug sensitivity in metastasizing ovarian cancer cells. -genetics_overexpression_promote hsa-mir-30a Nasopharyngeal Neoplasms 24812123 "Furthermore, over-expression of miR-30a transfected with precursor increased the ability of metastasis and invasion of NPC tumor cells in vivo and in vitro." -genetics_overexpression_promote hsa-mir-222 "Carcinoma, Hepatocellular" 24955159 "MiR-222 overexpression induced an enhancement of HepG2 cell proliferation in vitro, paralleling with an altered cell cycle progression via increased cell population in S phase." -genetics_overexpression_promote hsa-mir-23b Breast Neoplasms 24966325 Ectopic expression of the miRNAs in the weakly metastatic mouse 4TO7 mammary tumor cell line had no effect on proliferation or morphology of tumor cells in vitro but was found to increase lung metastasis in a mouse model of breast cancer metastasis. -genetics_overexpression_promote hsa-mir-24 Breast Neoplasms 24966325 Ectopic expression of the miRNAs in the weakly metastatic mouse 4TO7 mammary tumor cell line had no effect on proliferation or morphology of tumor cells in vitro but was found to increase lung metastasis in a mouse model of breast cancer metastasis. -genetics_overexpression_promote hsa-mir-27b Breast Neoplasms 24966325 Ectopic expression of the miRNAs in the weakly metastatic mouse 4TO7 mammary tumor cell line had no effect on proliferation or morphology of tumor cells in vitro but was found to increase lung metastasis in a mouse model of breast cancer metastasis. -genetics_overexpression_promote hsa-mir-9 Osteosarcoma 24969351 "The findings of our study suggest that increased miR-9 expression has a strong correlation with the aggressive progression of osteosarcoma and its overexpression is a statistically significant risk factor affecting overall survival, suggesting that increased miR-9 expression could be a valuable marker of tumor progression and for prognosis of osteosarcoma." -genetics_overexpression_promote hsa-mir-17 Gastric Neoplasms 25047501 Overexpression of miR-17 in gastric cancer is correlated with proliferation-associated oncogene amplification. -genetics_overexpression_promote hsa-mir-214 Cardiomegaly 25085702 Cardiac hypertrophy and dysfunction induced by overexpression of miR-214 in vivo. -genetics_overexpression_promote hsa-mir-195 Heart Failure 25100012 Cardiac overexpression of miR-195 results in pathological cardiac growth and heart failure in transgenic mice. -genetics_overexpression_promote hsa-mir-146a Breast Neoplasms 25123132 Overexpression of miR-146a in basal-like breast cancer cells confers enhanced tumorigenic potential in association with altered p53 status. -genetics_overexpression_promote hsa-mir-21 Gastric Neoplasms 25230738 "This meta-analysis indicates that miR-21 detection has a prognostic value in patients with gastric cancer. In addition, overexpression of miR-21 is associated with worse tumor differentiation, lymph node metastasis, and TNM stage." -genetics_overexpression_promote hsa-mir-196a Oral Neoplasms 25233933 "Functionally, miR-196 actively promoted cell migration and invasion without affecting cell growth." -genetics_overexpression_promote hsa-mir-21 Neoplasms [unspecific] 25241894 Ectopic expression of miR-21 and miR-29a promotes angiogenesis and tumor cell proliferation -genetics_overexpression_promote hsa-mir-223 Colorectal Carcinoma 25270282 Overexpression of miR-223 correlates with tumor metastasis and poor prognosis in patients with colorectal cancer. -genetics_overexpression_promote hsa-mir-410 Colorectal Carcinoma 25272045 MiR-410 is overexpressed in liver and colorectal tumors and enhances tumor cell growth by silencing FHL1 via a direct/indirect mechanism. -genetics_overexpression_promote hsa-mir-374a Neoplasms [unspecific] 25299640 The miR-545/374a cluster encoded in the Ftx lncRNA is overexpressed in HBV-related hepatocellular carcinoma and promotes tumorigenesis and tumor progression. -genetics_overexpression_promote hsa-mir-545 Neoplasms [unspecific] 25299640 The miR-545/374a cluster encoded in the Ftx lncRNA is overexpressed in HBV-related hepatocellular carcinoma and promotes tumorigenesis and tumor progression. -genetics_overexpression_promote hsa-mir-200c Breast Neoplasms 25329395 Overexpression of microRNA-200c predicts poor outcome in patients with PR-negative breast cancer. -genetics_overexpression_promote hsa-mir-184 "Squamous Cell Carcinoma, Head and Neck" 25351569 Treatment with the precursors of these miRNAs increases the proliferation and migration of HNSCC cells. -genetics_overexpression_promote hsa-mir-1269 "Carcinoma, Hepatocellular" 25472505 "overexpression of miR-1269 promotes cell proliferation in HCC through directly suppressing FOXO1, and functions as an oncomiR in HCC." -genetics_overexpression_promote hsa-mir-17 Hematologic Neoplasms 25597017 overexpression of miR-17-92 in a limited number of hematopoietic cells is sufficient to cause B cell malignancies. -genetics_overexpression_promote hsa-mir-34a Sensorineural Hearing Loss 25638533 "In the inner ear HEI-OC1 cell line, miR-34a overexpression inhibited SIRT1, leading to an increase in p53 acetylation and apoptosis." -genetics_overexpression_promote hsa-mir-29c Brain Disease [unspecific] 25678279 "over-expression of miR-29c effectively reduced Birc2 (also Bak1) mRNA and protein levels, increased infarct volume and apoptosis, and deteriorated neurological outcomes, whereas down-regulation played a neuroprotective role." -genetics_overexpression_promote hsa-mir-433 Ovarian Neoplasms 25684390 Overexpression of the microRNA miR-433 promotes resistance to paclitaxel through the induction of cellular senescence in ovarian cancer cells. -genetics_overexpression_promote hsa-mir-221 Neoplasms [unspecific] 25686829 Over-expression of miR-221 stimulated stem-like cells in luminal type of cancer and the miR-221 level was correlated with clinical outcome in breast cancer patients. -genetics_overexpression_promote hsa-mir-153 "Carcinoma, Hepatocellular" 25714700 Over-expression of miR-153 down-regulated the activity of Etoposide and Paclitaxel on cell cycle arrest of HepG2 cells and the effect of Sorafenib on the invasion and migration of HepG2 cells. -genetics_overexpression_promote hsa-mir-196a "Squamous Cell Carcinoma, Head and Neck" 25860510 "These results show that miR-196a and HOXB9 are overexpressed,perhaps co-ordinately, as HNSCC develops and exert a pro-tumourigenic phenotype in HNSCC and OPM cells." -genetics_overexpression_promote hsa-mir-21 "Carcinoma, Cervical" 25963606 Overexpression of miR-21 promotes the proliferation and migration of cervical cancer cells via the inhibition of PTEN. -genetics_overexpression_promote hsa-mir-125a Chronic Hepatitis B 25993287 "Conversely, the overexpression of miR-125a or knockdown of A20 mimicked HBx to enhance TRAIL susceptibility in hepatocytes." -genetics_overexpression_promote hsa-mir-196a Osteosarcoma 26045752 "Taken together, miR-196a should be an oncogene in osteosarcoma. The possible mechanism was that overexpression of miR-196a promoted proliferation of MG63 and U2OS cells by modulating the PTEN/PI3K/Akt signaling pathway." -genetics_overexpression_promote hsa-mir-221 "Carcinoma, Lung, Non-Small-Cell" 26131134 We found that miR-222 overexpression increased cell viability and proliferative rate in H460 cells while opposite effects were obtained by down-regulation of miR-222. -genetics_overexpression_promote hsa-mir-144 Diabetic Cardiomyopathies 26164195 The miR-144 mimics aggravated high glucose-induced ROS formation and apoptosis in cardiomyocytes -genetics_overexpression_promote hsa-mir-23a "Carcinoma, Laryngeal" 26171041 "Ectopic expression of miR-23a and knockdown of APAF-1 significantly promoted cell proliferation and colony formation, and inhibited early apoptosis in Hep2 cells." -genetics_overexpression_promote hsa-mir-132 "Diabetes Mellitus, Type 2" 26218441 Overexpression of miR-132 or miR-212 enhances glucose and GLP-1-stimulated insulin secretion. -genetics_overexpression_promote hsa-mir-212 "Diabetes Mellitus, Type 2" 26218441 Overexpression of miR-132 or miR-212 enhances glucose and GLP-1-stimulated insulin secretion. -genetics_overexpression_promote hsa-mir-331 Prostate Neoplasms 26259043 "Overexpression of miR-331-3p upregulated mesenchymal markers such as vimentin, N-cadherin, and snail and downregulated epithelial markers such as E-cadherin and desmoplakin in the prostate cancer cell line PC3." -genetics_overexpression_promote hsa-mir-93 "Squamous Cell Carcinoma, Esophageal" 26273410 "The introduction of miR-93 significantly promotes cell proliferation,cell cycle progression, and the metastatic capability of EC109 cells. " -genetics_overexpression_promote hsa-mir-20a Gastric Neoplasms 26286834 "ectopic expression of miR-20a dramatically decreased the expression of NFKBIB; increased the expression of p65, livin, and survivin" -genetics_overexpression_promote hsa-mir-215 Glioma 26317904 "In summary, miR-215 is overexpressed in human glioma, is involved in TGF-¦Â1-induced oncogenesis, and can be used as a marker of poor prognosis in glioma patients." -genetics_overexpression_promote hsa-mir-206 Cardiomegaly 26333362 Cardiac-specific overexpression of miR-206 in mice induced hypertrophy and protected the heart from ischemia/reperfusion injury -genetics_overexpression_promote hsa-mir-1207 Ovarian Neoplasms 26337084 MiR-1207 overexpression promotes cancer stem cell-like traits in ovarian cancer by activating the Wnt/¦Â-catenin signaling pathway. -genetics_overexpression_promote hsa-mir-302 Fanconi Anemia 26343459 "Taken together, our results suggest that overexpression of miR-302 plays a critical role in the regulation of FANCD2 monoubiquitination, resulting in characteristic defects in DNA repair within cells." -genetics_overexpression_promote hsa-mir-92a "Carcinoma, Lung, Non-Small-Cell" 26432332 "upregulation of miR-92a in NSCLC cells promoted cell proliferation, migration, and invasion, decreased apoptosis and caspase-3 activity, and enhanced chemoresistance of NSCLC cells, whereas downregulation of miR-92a showed the opposite effects." -genetics_overexpression_promote hsa-mir-451 "Squamous Cell Carcinoma, Head and Neck" 26506880 And overexpression of miRNA-451 in cells with low endogenous expression of miRNA-451 accelerated proliferation. -genetics_overexpression_promote hsa-mir-664 Osteosarcoma 26515813 Overexpression of miR-664 was associated with increased migration and invasive abilities of OS cells in vitro -genetics_overexpression_promote hsa-mir-221 Inflammation 26549234 Enforced expression of miR-221 significantly increased the production of proinflammatory cytokines -genetics_overexpression_promote hsa-mir-21 Asthma 26651881 "This study provides the first in vitro evidence that overexpression of miR-21 in HASM cells can trigger cell proliferation and migration, and the effects of miR-21 depend on the level of PTEN." -genetics_overexpression_promote hsa-mir-27b Cervical Neoplasms 26706910 "Upregulation of miR-27b significantly accelerated the proliferation, cell cycle transition from G1 to S phase, migration and invasion of C33A cells" -genetics_overexpression_promote hsa-mir-183 Colorectal Carcinoma 26717041 "over-expression of miR-183 resulted in the attenuation of rapamycin- or starvation-induced autophagy in cancer cells, whereas inhibition of endogenous miR-183 stimulated autophagy and apoptosis." -genetics_overexpression_promote hsa-mir-200a "Carcinoma, Nasopharyngeal" 26718506 Overexpression of miR-200a resulted in the proliferation of CNE2 cells. -genetics_overexpression_promote hsa-mir-203 Pancreatic Neoplasms 26719072 "miR-203 promotes proliferation, migration and invasion in pancreatic cancer cells" -genetics_overexpression_promote hsa-mir-421 Osteosarcoma 26758431 "overexpression of miR-421 promoted osteosarcoma cell line MG-63 proliferation, migration, and invasion." -genetics_overexpression_promote hsa-mir-21 Osteosarcoma 26779632 miR-21 overexpression in MG63 caused a significant raise in cell proliferation and invasion and a significant reduction in cell apoptosis. -genetics_overexpression_promote hsa-mir-222 Bladder Neoplasms 26800397 Overexpression of miR-222 attenuated cisplatin-induced cell death in bladder cancer cells. -genetics_overexpression_promote hsa-mir-96 Glioma 26846266 "In vivo, microRNA-96 overexpression inhibits the apoptosis and increases tumor growth." -genetics_overexpression_promote hsa-mir-21 Heart Failure 26865549 Overexpression of miR-21 in this monocyte cell line activated a fibrotic gene programme and promoted monocyte-to-fibrocyte transition -genetics_overexpression_promote hsa-mir-183 Glioma 26879754 "Introduction of miR-183 mimics into U251 cells could promoted, while its antisense oligos inhibited cell proliferation and invasion." -genetics_overexpression_promote hsa-mir-205 "Carcinoma, Nasopharyngeal" 26880795 "Overexpression of miR-205 increased the proliferation, migration and invasion of CNE2 cells" -genetics_overexpression_promote hsa-mir-21 "Carcinoma, Cervical" 26884851 "The overexpression of HPV E7 protein facilitated the expression of miR-21, which potentiated Hela cell proliferation and invasion." -genetics_overexpression_promote hsa-mir-138 Glioblastoma 26887050 Transient transfection of miR-138 mimics in glioma cells with low basal miR-138 expression increased glioma cell proliferation. -genetics_overexpression_promote hsa-mir-27b Cervical Neoplasms 26910911 "MiR-27b, up-regulated by E7, promoted CaSki and SiHa cell proliferation and invasion, inhibit paclitaxel-induced apoptosis." -genetics_overexpression_promote hsa-mir-195 Spinal Cord Injuries 26927342 "In addition, Ad-miR-195 also obviously increased the number of apoptotic cells and decreased the neurological recovery in the animals injected with Ad-miR-195." -genetics_overexpression_promote hsa-mir-449a Breast Neoplasms 26934316 "In vitro, miR-449a promoted breast cancer cell proliferation, clonogenic survival, migration, and invasion." -genetics_overexpression_promote hsa-mir-214 Breast Neoplasms 26951965 the overexpression of miRâ€?14 markedly increased cell viability and abrogated the apoptosis triggered by serum starvation -genetics_overexpression_promote hsa-mir-522 "Carcinoma, Hepatocellular" 26960688 "miR-522 overexpression promoted cell proliferation, colony formation, and cell cycle progression, whereas knockdown of miR-522 reduced these effects." -genetics_overexpression_promote hsa-mir-210 Kidney Neoplasms 26985942 ACHN cell proliferation and invasion were significantly increased and apoptosis was significantly decreased (P < 0.05) when miR-210 was overexpressed. -genetics_overexpression_promote hsa-mir-146a Chronic Hepatitis B 26996068 Overexpression of miR-146a reduced NK cell-mediated cytotoxicity -genetics_overexpression_promote hsa-mir-141 "Carcinoma, Nasopharyngeal" 27010857 ectopic expression of miR-141 can significantly promote cell proliferation and inhibit apoptosis in NPC -genetics_overexpression_promote hsa-mir-125a Juvenile Rheumatoid Arthritis 27014994 miR-125a-5p overexpression enhanced M2b polarization and altered other polarized populations -genetics_overexpression_promote hsa-mir-195 Myocardial Ischemic-Reperfusion Injury 27019437 "miR-195 expression was upregulated in myocardial I/R injury, and miR-195 overexpression may promote cardiomyocyte apoptosis by targeting Bcl-2 and inducing mitochondrial apoptotic pathway." -genetics_overexpression_promote hsa-mir-93 "Carcinoma, Gastric" 27021515 miR-93 promoted the development of gastric tumor growth in xenograft mice -genetics_overexpression_promote hsa-mir-9 Glioblastoma 27036038 "hsa-miR-9 overexpression leads to MAPKAP signaling inhibition, partially by interfering with the MAPK14/MAPKAP3 complex. Further, hsa-miR-9 overexpression initiates re-arrangement of actin filament" -genetics_overexpression_promote hsa-mir-221 Breast Neoplasms 27044817 "Enforced expression of miR-221/222 promoted breast cancer cell proliferation, migration and invasion via targeting PTEN/Akt pathway." -genetics_overexpression_promote hsa-mir-222 Breast Neoplasms 27044817 "Enforced expression of miR-221/222 promoted breast cancer cell proliferation, migration and invasion via targeting PTEN/Akt pathway." -genetics_overexpression_promote hsa-mir-373 "Squamous Cell Carcinoma, Esophageal" 27073718 "Overexpression of miR-373 in ECA109 cells enhanced proliferation, G1-phase cell proportion, migration, and invasion." -genetics_overexpression_promote hsa-mir-141 Breast Neoplasms 27075851 "Ectopic expression of miR-141 in nonexpressing MDA-MB-231 enhanced brain metastatic colonization (5/9 mice vs 0/10 mice,P= .02)." -genetics_overexpression_promote hsa-mir-92b "Carcinoma, Hepatocellular" 27100897 miR-92b could promote cell proliferation and metastasis of HCC in vitro and in vivo. -genetics_overexpression_promote hsa-mir-146a Multiple Myeloma 27102001 "overexpressing miR-146a in MSC, secretion of several cytokines and chemokines including CXCL1, IL6, IL-8, IP-10, MCP-1, and CCL-5 was elevated, resulting in the enhancement of MM cell viability and migration." -genetics_overexpression_promote hsa-mir-196a "Carcinoma, Hepatocellular" 27108614 "HCV core protein increased the expression of miRâ€?96a, and that overexpression of miRâ€?96a in the HepG2 and Huhâ€? HCC cell lines promoted cell proliferation by inducing the G1‑S transition." -genetics_overexpression_promote hsa-mir-449a Hepatitis B Virus Infection 27138288 "Ectopic miR-449a expression in HCC cells strongly enhanced HBV replication, transcription, progeny virions secretion, and antigen expression in a dose-dependent manner." -genetics_overexpression_promote hsa-mir-106a Gastric Neoplasms 27142596 "Abnormal over-expression of miR-106a significantly promoted gastric cancer cell proliferation, metastasis, inhibited the cell apoptosis." -genetics_overexpression_promote hsa-mir-96 "Carcinoma, Prostate" 27164937 Overexpressing miR-96 led to increased proliferation and colony formation of normal prostate epithelial cells. -genetics_overexpression_promote hsa-mir-410 Colorectal Carcinoma 27177325 overexpression of miRâ€?10 resulted in an increase in growth activity and decrease in the extent of apoptosis -genetics_overexpression_promote hsa-mir-937 Lung Neoplasms 27179609 Overexpression of miR-937 in A549 promoted anchorage -dependent and -independent growth -genetics_overexpression_promote hsa-mir-200b "Cytotoxicity Tests, Immunologic" 27183614 Cells overexpressing miR-200b/c or miR-217 showed reduced sensitivity to CDC -genetics_overexpression_promote hsa-mir-200c "Cytotoxicity Tests, Immunologic" 27183614 Cells overexpressing miR-200b/c or miR-217 showed reduced sensitivity to CDC -genetics_overexpression_promote hsa-mir-217 "Cytotoxicity Tests, Immunologic" 27183614 Cells overexpressing miR-200b/c or miR-217 showed reduced sensitivity to CDC -genetics_overexpression_promote hsa-mir-182 Liver Injury 27196584 "miR-182, which is associated with disease severity and liver injury." -genetics_overexpression_promote hsa-mir-126 "Neovascularization, Pathologic" 27203443 "silencing of miR-126-3p repressed angiogenesis, while overexpression of miR-126-5p enhanced angiogenesis." -genetics_overexpression_promote hsa-mir-21 Hypertrophic Scar 27207585 overexpression of miR-21 promoted fibroproliferative expression in fibroblasts. -genetics_overexpression_promote hsa-mir-125b "Carcinoma, Gastric" 27220320 Overexpression of miR-125b promoted gastric cancer cell migration and invasion in vitro and metastasis in vivo. -genetics_overexpression_promote hsa-mir-211 "Squamous Cell Carcinoma, Oral" 27221705 Induction of oral carcinogenesis in transgenic mice using 4-nitroquinoline 1-oxide (4NQO) resulted in more extensive and severe tongue tumorigenesis compared with control animals. -genetics_overexpression_promote hsa-mir-221 "Adenocarcinoma, Pancreatic Ductal" 27230035 Overexpressing miR-221 significantly increased cell vitality and promoted cell proliferation and G1-to-S phase transition of the cell cycle in Capan-2 cells -genetics_overexpression_promote hsa-mir-146a Alzheimer Disease 27241555 "Overexpression of miRNA-146a in SH-SY5Y cells significantly decreased Lrp2 expression, resulting in a reduction of Akt activation and induction of proapoptotic caspase-3, thereby increasing cell apoptosis." -genetics_overexpression_promote hsa-mir-182 Cerebral Ischemia 27242323 miR-182 plays an aggressive role in the cerebral ischemia injury -genetics_overexpression_promote hsa-mir-34a Osteoarthritis 27247228 Overexpression of miR-34a promoted apoptosis and inhibited cell proliferation in human chondrocytes -genetics_overexpression_promote hsa-mir-1908 Wound Healing 27256397 miR-1908 had a positive role in scar formation -genetics_overexpression_promote hsa-mir-1301 Prostate Neoplasms 27261573 miR-1301 promoted cell proliferation of prostate cancer. -genetics_overexpression_promote hsa-mir-205 Colorectal Carcinoma 27271572 miR-205 and miR-373 may differentially contribute to the aggressive phenotype of MAC in CRC. -genetics_overexpression_promote hsa-mir-373 Colorectal Carcinoma 27271572 miR-205 and miR-373 may differentially contribute to the aggressive phenotype of MAC in CRC. -genetics_overexpression_promote hsa-mir-206 Alzheimer Disease 27277332 miRâ€?06 upregulation enhanced LPS‑induced inflammation and Aβ release in microglia -genetics_overexpression_promote hsa-mir-21 Neuroblastoma 27285119 "Forced overexpression of miR-21 significantly increased NB cell proliferation, migration, and invasion." -genetics_overexpression_promote hsa-mir-18a "Squamous Cell Carcinoma, Esophageal" 27291152 upregulation of miR-18a promoted cell proliferation by increasing cylin D1 -genetics_overexpression_promote hsa-mir-429 Diabetes Mellitus 27299781 "increased miR-429 could down-regulate the expression of Ocln by targeting the Ocln 3'-UTR, which impaired intestinal barrier function in DM mice." -genetics_overexpression_promote hsa-mir-9 Influenza 27322373 Overexpression of miR-9 enhanced viral gene expression and production of infectious progeny -genetics_overexpression_promote hsa-mir-222 Gastric Neoplasms 27323780 "Gastrin-induced miR-222 overexpression resulted in reduced expression and cytoplasmic mislocalisation of p27kip1, which in turn caused actin remodelling and increased migration in AGSGR cells." -genetics_overexpression_promote hsa-mir-19a Glioma 27329239 Overexpression of miR-19a by a miR-19a mimic promoted glioma cell proliferation and invasion. -genetics_overexpression_promote hsa-mir-548a "Carcinoma, Hepatocellular" 27340352 "overexpression of miR-548a-5p in HCC cell lines promoted cell proliferation, increased colony forming ability and hampered cell apoptosis." -genetics_overexpression_promote hsa-mir-29a Atrial Fibrillation 27341015 miR-29a-3p transfection in cardiomyocytes produced the effects on the ICa -genetics_overexpression_promote hsa-mir-301b Lung Neoplasms 27352910 "ectopic expression of miR-301b enhanced cell population growth, reduced apoptosis and reduced sensitivity of cells to chemotherapy." -genetics_overexpression_promote hsa-mir-20a Uveal Melanoma 27356499 "miRâ€?0a mimics were transfected into UM cells, which led to increases in cell growth, migration and invasion activities." -genetics_overexpression_promote hsa-mir-92a "Carcinoma, Nasopharyngeal" 27366095 miR-92a overexpression potentiated the migration and invasion of 6-10B cells -genetics_overexpression_promote hsa-mir-340 Gastric Neoplasms 27374211 "Functionally, forced expression of miR-340 promoted cell viability, proliferation, colony formation and cell cycle progression in the SGC-7901 cells" -genetics_overexpression_promote hsa-mir-21 Cholesteatoma 27376830 miR-21 promotes the proliferation and invasion of cholesteatoma keratinocytes. -genetics_overexpression_promote hsa-mir-488 Osteosarcoma 27376839 "We also found that exogenous over-expression of microRNA-488 promotes the proliferation, reduces the apoptosis and decreases the sensitivity to chemotherapy (doxorubicin) of osteosarcoma cells" -genetics_overexpression_promote hsa-mir-205 Myelodysplastic Syndromes 27379838 Our findings suggest that miR-205-5p upregulation contributes to MDS by suppressing PTEN and that miR-205-5p thus acts as an oncogene in hematopoietic cells. -genetics_overexpression_promote hsa-mir-181b Gastric Neoplasms 27383203 Overexpression of miR-181b mimic induced an in vitro EMT-like change to a phenotype similar to that following TGF-β treatment alone and was reversed by miRNA-181b inhibitor. -genetics_overexpression_promote hsa-mir-27a Gastric Neoplasms 27409164 "And overexpression of miR-27a-3p, but not miR-27a-5p, markedly promoted gastric cancer cell proliferation in vitro as well as tumor growth in vivo." -genetics_overexpression_promote hsa-mir-92a Acute Myocardial Infarction 27411964 "Further, it could be observed in cellular experiments that treatment of miR-92a mimics can further upregulate endothelial injury markers." -genetics_overexpression_promote hsa-mir-92b Bladder Neoplasms 27430302 "In this study, we demonstrated that miR-92b could uniquely promote cell migration and invasion of BCa cells, but had no effect on cell proliferation." -genetics_overexpression_promote hsa-mir-1303 Neuroblastoma 27434867 "miR-1303 overexpression promoted the proliferation of SH-SY5Y NB cell investigated by MTT assay, colony formation assay and anchorage-independent growth ability assay, while miR-1303 knockdown reduced this effect." -genetics_overexpression_promote hsa-mir-146a Cerebral Ischemia 27449900 "In conclusion, our study revealed that miR-146a contributes to OGD/R injury in vitro." -genetics_overexpression_promote hsa-mir-940 "Carcinoma, Pancreatic" 27459115 Over-expression of microRNA-940 promotes cell proliferation by targeting GSK3β and sFRP1 in human pancreatic carcinoma. -genetics_overexpression_promote hsa-mir-181a Atherosclerosis 27460740 The exogenous overexpression of miR-181a accelerates the apoptosis rates of HUVECs in response to H2O2. -genetics_overexpression_promote hsa-mir-769 Melanoma 27470346 "Overexpression of miR-769 promoted cell proliferation in human melanoma cell line A375, whereas miR-769-in reverses the function." -genetics_overexpression_promote hsa-mir-183 "Carcinoma, Breast" 27476679 Overexpression of miR-183-5p significantly enhanced the cell proliferation and inhibited cell apoptosis in MCF-7 and MDA-MB-231 cells. -genetics_overexpression_promote hsa-mir-194 "Carcinoma, Ovarian" 27486333 "Overexpression of miR-194 in ovarian cancer cells promotes cell proliferation, migration, and invasion; in contrast, inhibition of the expression of miR-194 has the opposite effects." -genetics_overexpression_promote hsa-mir-195 Myocardial Ischemic-Reperfusion Injury 27489501 Up-regulation of miR-195 in ischemic cardiomyocytes promotes ischemic apoptosis by targeting Bcl-2. -genetics_overexpression_promote hsa-mir-363 Glioma 27495233 "Transfection of miR-363 induced cell survival, while inhibition of miR-363 significantly reduced glioma cell viability." -genetics_overexpression_promote hsa-mir-200c "Carcinoma, Gastric" 27498672 "Finally, ectopic expression of miR-200c or knockdown of DNMT3a expression impeded GC cell growth, migration and invasion." -genetics_overexpression_promote hsa-mir-15b "Carcinoma, Hepatocellular" 27499071 "It was observed that high expression of miR-15b promoted cell proliferation of the HCC cells, while low expression of miR-15b suppressed cell growth and induced the apoptosis of HepG2 cells." -genetics_overexpression_promote hsa-mir-17 Macular Degeneration 27505139 Transfection of miR-17-3p mimic in ARPE-19 induced cell death and exacerbated oxidative lethality that was alleviated by miR-17-3p inhibitor. -genetics_overexpression_promote hsa-mir-19b Lung Fibrosis 27508324 "Overexpression of miR-19b in small-airway epithelial cells promoted the mechanical stretch-induced EMT phenotypes, whereas inhibition of miR-19b attenuated it." -genetics_overexpression_promote hsa-mir-1 "Carcinoma, Colon" 27511117 overexpression of PIK3CA-premir1 in HCT116 and SW480 cells resulted in significant reduction of the sub-G1 cell distribution and apoptotic cell rate and resulted in increased cell proliferation. -genetics_overexpression_promote hsa-mir-483 "Carcinoma, Gastric" 27511210 overexpression of miRâ€?83â€?p by transfection with miRâ€?83â€?p mimics significantly increased cell proliferation and Annexin V‑propidium iodide staining indicated the suppression of cell apoptosis. -genetics_overexpression_promote hsa-mir-125b Retinoblastoma 27518550 overexpression of miR-125b apparently promotes RB cell proliferation and migration in vitro. -genetics_overexpression_promote hsa-mir-31 "Squamous Cell Carcinoma, Head and Neck" 27528032 miR-31 associated oncogenicities were rescued by ARID1A expression in HNSCC cells. -genetics_overexpression_promote hsa-mir-15b Neoplasms [unspecific] 27530410 increased miR-15b and decreased RECK expression may contribute to the pathobiology of LYO. -genetics_overexpression_promote hsa-mir-15b Uterine Leiomyoma 27530410 "Our findings suggest that miR-15b negatively regulates RECK expression in LYO, and increased miR-15b and decreased RECK expression may contribute to the pathobiology of LYO." -genetics_overexpression_promote hsa-mir-375 Liver Failure 27531059 "Thus miR-375 is identified as a novel repressor of UGT1A-mediated hepatic acetaminophen glucuronidation through reduced AhR expression, which could predispose some individuals to increased risk for acetaminophen-induced ALF" -genetics_overexpression_promote hsa-mir-181a "Leukemia, Myeloid, Acute" 27531761 Overexpression of miR-181a can promote AML cell proliferation. -genetics_overexpression_promote hsa-mir-29b Hearing Loss 27635430 miR-29b overexpression induces cochlear hair cell apoptosis through the regulation of SIRT1/PGC-1¦Á signaling: Implications for age-related hearing loss. -genetics_overexpression_promote hsa-mir-1288 "Squamous Cell Carcinoma, Esophageal" 27658568 Overexpression of miR-1288 play a key role in thepathogenesis of ESCCs and its modulation may have potential therapeutic value in patients with ESCC -genetics_overexpression_promote hsa-mir-9 Osteosarcoma 27724924 MiR-9 is overexpressed in spontaneous canine osteosarcoma and promotes a metastatic phenotype including invasion and migration in osteoblasts and osteosarcoma cell lines. -genetics_overexpression_promote hsa-mir-760 "Carcinoma, Ovarian" 27726922 MiR-760 overexpression promotes proliferation in ovarian cancer by downregulation of PHLPP2 expression. -genetics_overexpression_promote hsa-mir-182 "Squamous Cell Carcinoma, Head and Neck" 27744260 Overexpression of TP53 mutation-associated microRNA-182 promotes tumor cell proliferation and migration in head and neck squamous cell carcinoma. -genetics_overexpression_promote hsa-mir-138 Obesity 27762728 miR-138/miR-222 Overexpression Characterizes the miRNome of Amniotic Mesenchymal Stem Cells in Obesity. -genetics_overexpression_promote hsa-mir-222 Obesity 27762728 miR-138/miR-222 Overexpression Characterizes the miRNome of Amniotic Mesenchymal Stem Cells in Obesity. -genetics_overexpression_promote hsa-mir-212 "Adenocarcinoma, Pancreatic Ductal" 27814273 Overexpressions of miR-212 are associated with poor prognosis of patients with pancreatic ductal adenocarcinoma. -genetics_overexpression_promote hsa-mir-21 Choriocarcinoma 27922982 "miR-21 Is Overexpressed in Hydatidiform Mole Tissues and Promotes Proliferation, Migration, and Invasion in Choriocarcinoma Cells." -genetics_overexpression_promote hsa-mir-675 "Squamous Cell Carcinoma, Head and Neck" 27994496 Overexpression of lncRNA H19/miR-675 promotes tumorigenesis in head and neck squamous cell carcinoma. -genetics_overexpression_promote hsa-mir-375 Diabetes Mellitus 28017506 Insulin producing cells generation by overexpression of miR-375 in adipose-derived mesenchymal stem cells from diabetic patients. -genetics_overexpression_promote hsa-mir-223 Glioblastoma 28035389 "overexpression of miR-223 increases TMZ chemoresistance, while inhibition of miR-223 with antagomir markedly decreases TMZ chemoresistance in GBM cells" -genetics_overexpression_promote hsa-mir-92a Osteosarcoma 28069547 Overexpression of miR-92a promotes the tumor growth of osteosarcoma by suppressing F-box and WD repeat-containing protein 7. -genetics_overexpression_promote hsa-mir-205 Endometrial Neoplasms 28105153 Overexpression of microRNA-205 predicts lymph node metastasis and indicates an unfavorable prognosis in endometrial cancer. -genetics_overexpression_promote hsa-mir-196b Myelodysplastic Syndromes 28224273 Over-expression of miR-196b-5p is significantly associated with the progression of myelodysplastic syndrome. -genetics_overexpression_promote hsa-mir-214 Osteosarcoma 28260089 Overexpression of miR?214 promotes the progression of human osteosarcoma by regulating the Wnt/¦Â?catenin signaling pathway. -genetics_overexpression_promote hsa-mir-320 Ovarian Neoplasms 28338235 Overexpression of Hsa-miR-320 Is Associated With Invasion and Metastasis of Ovarian Cancer. -genetics_overexpression_promote hsa-mir-10b Colorectal Carcinoma 28345456 Overexpression of miR-10b in colorectal cancer patients: Correlation with TWIST-1 and E-cadherin expression. -genetics_overexpression_promote hsa-mir-221 Ovarian Neoplasms 28350128 Overexpression of miRNA-221 promotes cell proliferation by targeting the apoptotic protease activating factor-1 and indicates a poor prognosis in ovarian cancer. -genetics_overexpression_promote hsa-mir-196b "Carcinoma, Ovarian" 28387653 Overexpression of microRNA-196b Accelerates Invasiveness of Cancer Cells in Recurrent Epithelial Ovarian Cancer Through Regulation of Homeobox A9. -genetics_overexpression_promote hsa-mir-1 Myocardial Infarction 28397788 Over-expression of microRNA-1 causes arrhythmia by disturbing intracellular trafficking system. -genetics_overexpression_promote hsa-mir-34a Colorectal Adenocarcinoma 28624481 "miR-34a overexpression predicts poor prognostic outcome in colorectal adenocarcinoma, independently of clinicopathological factors with established prognostic value." -genetics_overexpression_promote hsa-let-7 "Carcinoma, Hepatocellular" 28796071 Overexpression of microRNA let-7 correlates with disease progression and poor prognosis in hepatocellular carcinoma -genetics_overexpression_promote hsa-let-7a "Carcinoma, Hepatocellular" 28796071 Overexpression of microRNA let-7 correlates with disease progression and poor prognosis in hepatocellular carcinoma -genetics_overexpression_promote hsa-let-7e "Carcinoma, Hepatocellular" 28796071 Overexpression of microRNA let-7 correlates with disease progression and poor prognosis in hepatocellular carcinoma -genetics_overexpression_promote hsa-mir-194 Colorectal Carcinoma 29109785 Overexpression of miR-194 Reverses HMGA2-driven Signatures in Colorectal Cancer. -genetics_overexpression_promote hsa-mir-10b Neoplasms [unspecific] 29262659 "the overexpression of miR-10b was significantly correlated with metastasis status, and indicated the potential clinical use of miR-10b as a molecular biomarker, particularly in assessing prognosis for patients with cancers" -genetics_overexpression_promote hsa-mir-130a "Leukemia, Myeloid, Acute" 29493383 MiR-130a is aberrantly overexpressed in adult acute myeloid leukemia with t(8;21) and its suppression induces AML cell death. -genetics_overexpression_promote hsa-mir-155 "Leukemia, Myeloid, Acute" 29657293 miR-155 overexpression plays a key pathogenic role in some lymphomas and acute myeloid leukemias has led to the development of an antagomir-based approach as a new promising therapeutic strategy -genetics_overexpression_promote hsa-mir-19a Multiple Myeloma 29665917 "miR-19a is overexpressed significantly in Lp-1 and U266 multiple myeloma cells, and promots the proliferation and invasion of the myeloma cells, but inhibits their apoptosis" -genetics_overexpression_promote hsa-mir-34a Pituitary Adenoma 30109259 Overexpression of microRNA-34a Attenuates Proliferation and Induces Apoptosis in Pituitary Adenoma Cells via SOX7. -genetics_overexpression_promote hsa-mir-221 "Carcinoma, Breast" 30110679 Our findings provide strong evidence that miR-9 and miR-221 can enhance the generation of cancer stem cells to yield an invasive phenotype and that overexpression of these miRNAs predicts a poor outcome for breast cancer patients -genetics_overexpression_promote hsa-mir-9 "Carcinoma, Breast" 30110679 Our findings provide strong evidence that miR-9 and miR-221 can enhance the generation of cancer stem cells to yield an invasive phenotype and that overexpression of these miRNAs predicts a poor outcome for breast cancer patients -genetics_overexpression_promote hsa-mir-214 Myeloma 30357841 "Bone marrow fibroblasts overexpress miR-27b and miR-214 in step with multiple myeloma progression, dependent on tumour cell-derived exosomes." -genetics_overexpression_promote hsa-mir-27b Myeloma 30357841 "Bone marrow fibroblasts overexpress miR-27b and miR-214 in step with multiple myeloma progression, dependent on tumour cell-derived exosomes." -genetics_overexpression_promote hsa-mir-301a Colorectal Carcinoma 30362160 Overexpression of miR-301a-3p promotes colorectal cancer cell proliferation and metastasis by targeting deleted in liver cancer-1 and runt-related transcription factor 3. -genetics_overexpression_promote hsa-mir-361 "Adenocarcinoma, Lung" 30365047 Overexpression of miR?361?5p plays an oncogenic role in human lung adenocarcinoma through the regulation of SMAD2. -genetics_overexpression_suppress hsa-mir-125b-1 "Carcinoma, Hepatocellular" 18649363 miR-125b: overexpression of miR-125b in HCC cell line could obviously suppress the cell growth and phosporylation of Akt -genetics_overexpression_suppress hsa-mir-125b-2 "Carcinoma, Hepatocellular" 18649363 miR-125b: overexpression of miR-125b in HCC cell line could obviously suppress the cell growth and phosporylation of Akt -genetics_overexpression_suppress hsa-mir-142 Lung Neoplasms 19228723 "miR-142-5p: were repressed, overexpression can inhibitu lung cancer growth" -genetics_overexpression_suppress hsa-mir-145 Lung Neoplasms 19228723 "miR-145: were repressed, overexpression can inhibitu lung cancer growth" -genetics_overexpression_suppress hsa-mir-34c Lung Neoplasms 19228723 "miR-34c: were repressed, overexpression can inhibitu lung cancer growth" -genetics_overexpression_suppress hsa-mir-100 Ovarian Neoplasms 20081105 "Overexpression of mir-100 inhibited mTOR signaling and enhanced sensitivity to the rapamycin analog RAD001 (everolimus), confirming the key relationship between mir-100 and the mTOR pathway." -genetics_overexpression_suppress hsa-mir-22 Ovarian Neoplasms 20081105 "overexpression of the putative tumor suppressor mir-22 repressed the EVI1 oncogene, which is known to suppress apoptosis by stimulating phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene homolog 1 signaling." -genetics_overexpression_suppress hsa-mir-194 Liver Neoplasms 20979124 The overexpression of miR-194 in liver mesenchymal-like cancer cells reduced the expression of the mesenchymal cell marker N-cadherin and suppressed invasion and migration of the mesenchymal-like cancer cells both in vitro and in vivo -genetics_overexpression_suppress hsa-let-7a-1 Hypertrophy 21183740 Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7. -genetics_overexpression_suppress hsa-let-7a-2 Hypertrophy 21183740 Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7. -genetics_overexpression_suppress hsa-let-7a-3 Hypertrophy 21183740 Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7. -genetics_overexpression_suppress hsa-let-7b Hypertrophy 21183740 Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7. -genetics_overexpression_suppress hsa-let-7c Hypertrophy 21183740 Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7. -genetics_overexpression_suppress hsa-let-7d Hypertrophy 21183740 Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7. -genetics_overexpression_suppress hsa-let-7e Hypertrophy 21183740 Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7. -genetics_overexpression_suppress hsa-let-7f-1 Hypertrophy 21183740 Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7. -genetics_overexpression_suppress hsa-let-7f-2 Hypertrophy 21183740 Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7. -genetics_overexpression_suppress hsa-let-7g Hypertrophy 21183740 Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7. -genetics_overexpression_suppress hsa-let-7i Hypertrophy 21183740 Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7. -genetics_overexpression_suppress hsa-mir-98 Hypertrophy 21183740 Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7. -genetics_overexpression_suppress hsa-mir-146a Atherosclerosis 21329689 Over-expression of miR-146a may be useful in the prevention and treatment of atherosclerosis. -genetics_overexpression_suppress hsa-mir-128 Glioblastoma 21358821 "Our analysis predicted a significant association between miR-128 and the protein kinase WEE1, which we subsequently validated experimentally by showing that the over-expression of the naturally under-expressed miR-128 in glioma cells resulted in the inhibition of WEE1 in glioblastoma cells." -genetics_overexpression_suppress hsa-mir-663 Leukemia 21518471 "miRNA-663 in K562 cells is up-regulated after 5-aza treatment. Over-expression of miR-663 can suppress the proliferation of K562 cells, which suggests that miR-663 may possesses suppressive effect for leukaemia." -genetics_overexpression_suppress hsa-mir-146b Lung Neoplasms 21789255 Overexpression of the Lung Cancer-Prognostic miR-146b MicroRNAs Has a Minimal and Negative Effect on the Malignant Phenotype of A549 Lung Cancer Cells. -genetics_overexpression_suppress hsa-mir-199a-1 "Carcinoma, Hepatocellular" 21847633 Lentivirus-Mediated Overexpression of MicroRNA-199a Inhibits Cell Proliferation of Human Hepatocellular Carcinoma. -genetics_overexpression_suppress hsa-mir-199a-2 "Carcinoma, Hepatocellular" 21847633 Lentivirus-Mediated Overexpression of MicroRNA-199a Inhibits Cell Proliferation of Human Hepatocellular Carcinoma. -genetics_overexpression_suppress hsa-mir-16 Acute Lung Injury 22185353 "Accordingly, over-expression of miR-16 could significantly suppress the luciferase activity of reporter fusion with the binding sites of TNF¦Á in its 3'UTR region, suggesting that miR-16 played its role in LPS-induced lung inflammation by a direct manner." -genetics_overexpression_suppress hsa-mir-10a "Leukemia, Myeloid, Acute" 22348345 miR-10a is aberrantly overexpressed in Nucleophosmin1 mutated Acute Myeloid Leukaemia and its suppression induces cell death. -genetics_overexpression_suppress hsa-mir-143 Colon Neoplasms 22362069 "Overexpression of three miRNA (miR200c*, miR143*, and miR424*) significantly abrogated invasive potential." -genetics_overexpression_suppress hsa-mir-200c Colon Neoplasms 22362069 "Overexpression of three miRNA (miR200c*, miR143*, and miR424*) significantly abrogated invasive potential." -genetics_overexpression_suppress hsa-mir-424 Colon Neoplasms 22362069 "Overexpression of three miRNA (miR200c*, miR143*, and miR424*) significantly abrogated invasive potential." -genetics_overexpression_suppress hsa-let-7a-1 Esophageal Neoplasms 22363450 "Curcumin treatment down-regulate the expressions of Notch-1 specific microRNAs miR-21 and miR-34a, and upregulated tumor suppressor let-7a miRNA." -genetics_overexpression_suppress hsa-let-7a-2 Esophageal Neoplasms 22363450 "Curcumin treatment down-regulate the expressions of Notch-1 specific microRNAs miR-21 and miR-34a, and upregulated tumor suppressor let-7a miRNA." -genetics_overexpression_suppress hsa-let-7a-3 Esophageal Neoplasms 22363450 "Curcumin treatment down-regulate the expressions of Notch-1 specific microRNAs miR-21 and miR-34a, and upregulated tumor suppressor let-7a miRNA." -genetics_overexpression_suppress hsa-mir-29a Ovarian Neoplasms 22479643 over-expression of miR-29a in vitro repressed several anti-correlated genes (including DNMT3A and DNMT3B) and substantially decreased ovarian cancer cell viability. -genetics_overexpression_suppress hsa-let-7a-1 Colorectal Carcinoma 22584434 High let-7a microRNA levels in KRAS-mutated colorectal carcinomas may rescue anti-EGFR therapy effects in patients with chemotherapy-refractory metastatic disease. -genetics_overexpression_suppress hsa-let-7a-2 Colorectal Carcinoma 22584434 High let-7a microRNA levels in KRAS-mutated colorectal carcinomas may rescue anti-EGFR therapy effects in patients with chemotherapy-refractory metastatic disease. -genetics_overexpression_suppress hsa-let-7a-3 Colorectal Carcinoma 22584434 High let-7a microRNA levels in KRAS-mutated colorectal carcinomas may rescue anti-EGFR therapy effects in patients with chemotherapy-refractory metastatic disease. -genetics_overexpression_suppress hsa-mir-92a-1 "Carcinoma, Hepatocellular" 22587342 Oxidative DNA damage correlates with cell immortalization and mir-92 expression in hepatocellular carcinoma. -genetics_overexpression_suppress hsa-mir-34b "Carcinoma, Lung, Non-Small-Cell" 22593438 Overexpression of miR-34b significantly reduced cell survival at lower than 4 Gy radiation doses. -genetics_overexpression_suppress hsa-mir-223 Rheumatoid Arthritis 22903258 Overexpression of microRNA-223 in rheumatoid arthritis synovium controls osteoclast differentiation. -genetics_overexpression_suppress hsa-let-7b "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 22918121 The enforced expression of let-7b in ALL cell lines with an MLL fusion gene inhibited their growth. -genetics_overexpression_suppress hsa-mir-34a Melanoma 22969970 "These results suggest that overexpression of miR-34a and c suppresses invasive and generative potentials, respectively, in human malignant melanoma." -genetics_overexpression_suppress hsa-mir-34c Melanoma 22969970 "All four melanoma cell lines showed significant expression of miR-34s - A375: miR-34a 0.6176, miR-34b 0.7625, miR-34c 0.7877; " -genetics_overexpression_suppress hsa-mir-124 Medulloblastoma 23172372 "MiR-124 overexpression inhibits the proliferation of medulloblastoma cells, and this effect is mediated mostly through the action of miR-124 upon CDK6." -genetics_overexpression_suppress hsa-mir-142 Gastric Neoplasms 23209550 Overexpression of miR-142-5p and miR-155 in Gastric Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma Resistant to Helicobacter pylori Eradication -genetics_overexpression_suppress hsa-mir-155 Gastric Neoplasms 23209550 Overexpression of miR-142-5p and miR-155 in Gastric Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma Resistant to Helicobacter pylori Eradication -genetics_overexpression_suppress hsa-mir-19b Cardiovascular Diseases [unspecific] 23443808 "Overexpression of miR-19b inhibited activation of the Wnt/¦Â-catenin signaling pathway in P19 cells, which may regulate cardiomyocyte differentiation." -genetics_overexpression_suppress hsa-mir-133a Hypertension 23460283 "In vitro overexpression of miR-27a,-29a, and -133a inhibited cardiomyocyte hypertrophy and reduced collagen expression. " -genetics_overexpression_suppress hsa-mir-27a Hypertension 23460283 "In vitro overexpression of miR-27a,-29a, and -133a inhibited cardiomyocyte hypertrophy and reduced collagen expression. " -genetics_overexpression_suppress hsa-mir-29a Hypertension 23460283 "In vitro overexpression of miR-27a,-29a, and -133a inhibited cardiomyocyte hypertrophy and reduced collagen expression. " -genetics_overexpression_suppress hsa-mir-155 Ovarian Neoplasms 23523916 overexpression of miR-155 may prevent tumorigenesis in human ovarian cancer through downregulation of CLDN1. -genetics_overexpression_suppress hsa-mir-138-1 Neuroblastoma 23562653 miR-138 Overexpression is more powerful than hTERT knockdown to potentiate apigenin for apoptosis in neuroblastoma in vitro and in vivo -genetics_overexpression_suppress hsa-mir-138-2 Neuroblastoma 23562653 miR-138 Overexpression is more powerful than hTERT knockdown to potentiate apigenin for apoptosis in neuroblastoma in vitro and in vivo -genetics_overexpression_suppress hsa-mir-34a Gastric Neoplasms 24068565 "miR-34a over-expression could improve the sensitivity of gastric cancer cells against cisplatin-based chemotherapies, with PI3K/AKT/survivin signaling pathway possibly involved in the mechanism." -genetics_overexpression_suppress hsa-mir-181b Atherosclerosis 24084690 overexpression of miR-181b in the aortic intima of apolipoprotein E-deficient mice and suppressed NF-¦ÊB signaling revealed by bioluminescence imaging and reduced target gene expression in the aortic arch in apolipoprotein E-deficient/NF-¦ÊB-luciferase transgenic mice. -genetics_overexpression_suppress hsa-mir-129 Medulloblastoma 24093088 Overexpression of miR-129-5p using mimics decreased DAOY proliferation -genetics_overexpression_suppress hsa-let-7a Neoplasms [unspecific] 24100239 Human Argonaute-3 specifically enhances the passenger strand expression and activity of the tumor suppressor microRNA let-7a. -genetics_overexpression_suppress hsa-mir-486 Breast Neoplasms 24104550 "in vitro functional screening of the downregulated miRNAs in non-malignant and breast cancer cell lines identified several possible tumor suppressor miRNAs, including miR-193b, miR-193a-3p, miR-126, miR-134, miR-132, miR-486-5p, miR-886-3p, miR-195 and miR-497, showing reduced growth when re-expressed in cancer cells" -genetics_overexpression_suppress hsa-let-7a "Diabetes Mellitus, Type 2" 24105413 "Expression of microRNA let-7a and let-7d, which are direct translational repressors of the IL-13 gene, was increased in skeletal muscle from T2DM patients. " -genetics_overexpression_suppress hsa-mir-200c Melanoma 24120113 Overexpression of microRna-200c in CD44+CD133+ CSCS inhibits the cellular migratory and invasion as well as tumorigenicity in mice. -genetics_overexpression_suppress hsa-mir-145 Melanoma 24248543 Overexpression of miR-145 increases the sensitivity of vemurafenib in drug-resistant colo205 cell line. -genetics_overexpression_suppress hsa-mir-449a "Adenocarcinoma, Gastric" 24260067 The overexpression of miR-449a inhibited gastric adenocarcinoma cell growth and promoted cell apoptosis in the MGC-803 and SGC-7901 gastric adenocarcinoma cell lines. -genetics_overexpression_suppress hsa-let-7a Ewing Sarcoma 24383407 "Restored let-7a expression inhibited cell proliferation, migration, as well as invasion; arrested cell cycle progression; and induced cell apoptosis of both cell lines." -genetics_overexpression_suppress hsa-mir-133b Gastric Neoplasms 24443799 MiR-133b is frequently decreased in gastric cancer and its overexpression reduces the metastatic potential of gastric cancer cells. -genetics_overexpression_suppress hsa-mir-24 Heart Failure 24454859 "In vivo delivery of miR-24 into a mouse MI model suppressed cardiac cell death, attenuated infarct size, and rescued cardiac dysfunction." -genetics_overexpression_suppress hsa-mir-34a "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 24482044 Ectopic expression of miR-34a and miR-34c in Hep-2 cells significantly induced the cell proliferation and migration ability in vitro. -genetics_overexpression_suppress hsa-mir-34c "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 24482044 Ectopic expression of miR-34a and miR-34c in Hep-2 cells significantly induced the cell proliferation and migration ability in vitro. -genetics_overexpression_suppress hsa-mir-107 Breast Neoplasms 24482686 "Overexpression of miR-107 suppressed MDA-MB-231 cell proliferation and migration, meanwhile the cells were arrested at G0/G1 phase." -genetics_overexpression_suppress hsa-mir-7 Liver Neoplasms 24491049 "Over-expression of miR-7 could significantly inhibit the growth of human lung cancer cells in vivo and in vitro, which might be related to the down-regulated expression of tumor growth-associated protein CGGBP1." -genetics_overexpression_suppress hsa-mir-21 Atherosclerosis 24502419 "Further analysis confirmed that overexpression of miR-21 by transfection with miR-21 mimics notably attenuated lipid accumulation and lipid-laden foam cell formation in LPS-stimulated macrophages, which was reversely up-regulated when silencing miR-21 expression via anti-miR-21 inhibitor transfection, indicating a reverse regulator of miR-21 in LPS-induced foam cell formation." -genetics_overexpression_suppress hsa-let-7c Ovarian Neoplasms 24507678 "After application of let-7c, number of T29A2+ cell clones was decreased significantly, however, after the application of Anti-let-7, the number of clones restored, and there was no significant difference compared with the negative control group." -genetics_overexpression_suppress hsa-mir-29a Diabetes Mellitus 24578127 "Diabetic miR-29a transgenic mice had better nephrin levels, podocyte viability, and renal function and less glomerular fibrosis and inflammation reaction compared with diabetic wild-type mice." -genetics_overexpression_suppress hsa-mir-206 Ovarian Neoplasms 24604205 microRNA-206 overexpression inhibits cellular proliferation and invasion of estrogen receptor ¦Á-positive ovarian cancer cells. -genetics_overexpression_suppress hsa-mir-183 Neuropathic Pain 24612023 "Intrathecal administration of lentivirions expressing miR-183 downregulated SNL-induced increases in the expression of Nav1.3 and brain-derived neurotrophic factor (BDNF), which correlated with the significant attenuation of SNL-induced mechanical allodynia." -genetics_overexpression_suppress hsa-mir-143 Leukemia 24626955 Overexpression of microRNA-143 inhibits growth and induces apoptosis in human leukemia cells. -genetics_overexpression_suppress hsa-mir-499 Heart Failure 24646523 "We report that cardiac-abundant miR-499 could protect neonatal rat cardiomyocytes against H 2O 2-induced apoptosis. Increased miR-499 level favored survival, while decreased miR-499 level favored apoptosis." -genetics_overexpression_suppress hsa-mir-499 Myocardial Infarction 24646523 "We report that cardiac-abundant miR-499 could protect neonatal rat cardiomyocytes against H 2O 2-induced apoptosis. Increased miR-499 level favored survival, while decreased miR-499 level favored apoptosis." -genetics_overexpression_suppress hsa-mir-155 Glioblastoma 24705102 "Over-expression of miR-136 and miR-634 miRNAs negatively affected proliferation, but not migration, while expression of miR-155 reduced migration but did not affect the proliferation of LN229 cells." -genetics_overexpression_suppress hsa-mir-155 Arthritis 24708712 Overexpression of miR-155 in the gouty SFMC leads to suppress SHIP-1 levels and enhance proinflammatory cytokines. -genetics_overexpression_suppress hsa-mir-34a "Carcinoma, Renal Cell" 24765202 "The Cell Counting Kit-8 identified that transient forced expression of miR-34a inhibited cell growth and resulted in cell cycle arrest, which was evaluated by flow cytometry." -genetics_overexpression_suppress hsa-mir-206 "Carcinoma, Hepatocellular" 24919811 "MicroRNA-206 overexpression promotes apoptosis, induces cell cycle arrest and inhibits the migration of human hepatocellular carcinoma HepG2 cells." -genetics_overexpression_suppress hsa-mir-99a Bladder Neoplasms 24944696 "It was found that miRNA-99a inhibits cell proliferation, migration and invasion in T24 and EJ cells." -genetics_overexpression_suppress hsa-mir-34a Glioma 24944883 "Ectopic expression of miR-34a in glioma stem cell-lines HNGC-2 and NSG-K16 decreased the proliferative and migratory potential of these cells, induced cell cycle arrest and caused apoptosis." -genetics_overexpression_suppress hsa-mir-146a Ischemia-Reperfusion Injury 24987958 "Overexpression of miR-146a directly decreased IRAK1 and TRAF6 expression and attenuated the release of proinflammatory cytokines through the inactivation of NF-κB P65 in hypoxia/reoxygenation (H/R)-induced macrophages, RAW264.7 cells." -genetics_overexpression_suppress hsa-let-7 Pancreatic Neoplasms 25017900 "Sulforaphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction and K-ras inhibition." -genetics_overexpression_suppress hsa-mir-7 Neurodegenerative Diseases [unspecific] 25071443 "Overexpression of miR-7 or miR-153 by adenoviral transduction protected cortical neurons from MPP(+)-induced toxicity, restored neuronal viability and anti-apoptotic BCL-2 protein levels while attenuated activation of caspase-3." -genetics_overexpression_suppress hsa-mir-155 Cerebral Malaria 25189739 AAV8-mediated in vivo overexpression of miR-155 enhances the protective capacity of genetically attenuated malarial parasites. -genetics_overexpression_suppress hsa-let-7d "Carcinoma, Renal Cell" 25193015 "Functional studies indicated that ectopic expression of let-7d significantly inhibited RCC cell proliferation, migration, and peripheral blood monocyte (PBMC) recruitment in vitro, as well as tumor growth, metastasis, and tumor macrophage infiltration in vivo." -genetics_overexpression_suppress hsa-let-7g Osteosarcoma 25197332 "Functional investigation revealed both restoration of let-7g and silencing Aurora-B induce cell apoptosis and suppressed cell viability, migratory and invasive ability in OS cells." -genetics_overexpression_suppress hsa-mir-449a "Carcinoma, Gastric" 25202363 The level of MGC-803 cell proliferation was decreased and the apoptosis level was increased by the upregulation of miR-449a expression -genetics_overexpression_suppress hsa-mir-200b Hypertrophic Scar 25228082 Overexpression of miR-200b inhibits the cell proliferation and promotes apoptosis of human hypertrophic scar fibroblasts in vitro. -genetics_overexpression_suppress hsa-mir-206 "Squamous Cell Carcinoma, Oral" 25246801 "upregulation of miR-206 in Tca8113 cells was able to reduce cell proliferation, invasion, and migration and promote cell apoptosis in vitro." -genetics_overexpression_suppress hsa-mir-200c Lung Neoplasms 25277203 miR-200c overexpression is associated with better efficacy of EGFR-TKIs in non-small cell lung cancer patients with EGFR wild-type. -genetics_overexpression_suppress hsa-mir-21 Ischemia-Reperfusion Injury 25322693 miR-21 is endowed with anti-apoptotic properties by suppressing the expression of PDCD4 gene and active caspase 3/8 fragments in the condition of renal IRI. -genetics_overexpression_suppress hsa-mir-7 Lung Neoplasms 25334070 "Restoration of miR-7 inhibited 3LL cell proliferation, induced cell apoptosis in vitro and reduced tumorigenicity in vivo." -genetics_overexpression_suppress hsa-mir-30b "Carcinoma, Laryngeal" 25356506 Overexpression of microRNA-30b improves adenovirus-mediated p53 cancer gene therapy for laryngeal carcinoma. -genetics_overexpression_suppress hsa-mir-218 "Carcinoma, Hepatocellular" 25374061 Overexpression of miR-218 inhibits hepatocellular carcinoma cell growth through RET. -genetics_overexpression_suppress hsa-let-7g "Carcinoma, Hepatocellular" 25435961 "the overexpression of let-7g/i significantly suppressed DNA replication, inhibited cell proliferation and promoted apoptosis of BEL-7402 hepatoma cells." -genetics_overexpression_suppress hsa-let-7i "Carcinoma, Hepatocellular" 25435961 "the overexpression of let-7g/i significantly suppressed DNA replication, inhibited cell proliferation and promoted apoptosis of BEL-7402 hepatoma cells." -genetics_overexpression_suppress hsa-mir-133a Myocardial Infarction 25465869 "miR-133a overexpression protected CPCs against cell death, targeting, among others, the proapoptotic genes Bim and Bmf." -genetics_overexpression_suppress hsa-mir-150 Myocardial Infarction 25466411 "In vivo studies showed that overexpression of miR-150 in mice resulted in improved cardiac function, reduced myocardial infarction size, inhibition of apoptosis, and reduced inflammatory Ly-6C(high) monocyte invasion levels after AMI." -genetics_overexpression_suppress hsa-let-7b Gastric Neoplasms 25510669 "Ectopic expression of let-7b suppressed the growth, migration, invasion, and tumorigenicity of GC cells, whereas let-7b knockdown promoted these phenotypes." -genetics_overexpression_suppress hsa-mir-16 Glioma 25511497 miR-16 can significantly inhibit the in vivo growth of U87MG glioma. -genetics_overexpression_suppress hsa-let-7 Gastric Neoplasms 25549793 There were significant negative correlations between serum let-7c and its target gene PGC expression -genetics_overexpression_suppress hsa-mir-10a Congenital Diaphragmatic Hernia 25563880 Human fetal hypoplastic CDH lungs have a specific miR-200/miR-10a signature. Survival after FETO is associated with increased miR-200 family expression. miR-200b overexpression in CDH lungs results in decreased TGF-¦Â/SMAD signaling. -genetics_overexpression_suppress hsa-mir-200 Congenital Diaphragmatic Hernia 25563880 Human fetal hypoplastic CDH lungs have a specific miR-200/miR-10a signature. Survival after FETO is associated with increased miR-200 family expression. miR-200b overexpression in CDH lungs results in decreased TGF-¦Â/SMAD signaling. -genetics_overexpression_suppress hsa-mir-200b Congenital Diaphragmatic Hernia 25563880 Human fetal hypoplastic CDH lungs have a specific miR-200/miR-10a signature. Survival after FETO is associated with increased miR-200 family expression. miR-200b overexpression in CDH lungs results in decreased TGF-¦Â/SMAD signaling. -genetics_overexpression_suppress hsa-mir-146b Cervical Neoplasms 25572123 "miRâ€?46bâ€?p was able to inhibit the proliferative, invasive and adhesive potential and block the cell cycle progression of Caski human cervical cancer cells" -genetics_overexpression_suppress hsa-mir-143 Osteosarcoma 25576341 Forced miR-143 expression significantly inhibited tumor growth in xenograft SAOS-2-Dox and U2OS-Dox animal models. -genetics_overexpression_suppress hsa-let-7b Uveal Melanoma 25588203 We then confirmed that let-7b mimics could inhibit UM growth both in vitro and in vivo. -genetics_overexpression_suppress hsa-mir-214 Ischemia-Reperfusion Injury 25593579 Transfection of miR-214 mimic showed protective effects on OGD-induced injury to H9c2 cells by reducing apoptosis -genetics_overexpression_suppress hsa-mir-17 Melanoma 25594054 "The melanoma tumors formed in mice overexpressing miR-17 were less than that in wild type mice. In addition, the miR-17 tumors were less invasive and less angiogenic." -genetics_overexpression_suppress hsa-let-7 Neoplasms [unspecific] 25597880 let-7 microRNA would be involved in over-expression of cofilin-1 mediated tumor suppression in vitro and in vivo. -genetics_overexpression_suppress hsa-mir-30a Hepatitis B Virus Infection 25620738 "HBx induces autophagosome formation via beclin-1 expression, whereas miRNA-30a overexpression could successfully inhibit the beclin-1 expression induced by HBx, thereby modulating autophagosome formation in hepatic cells." -genetics_overexpression_suppress hsa-mir-29a Glioblastoma 25625222 "Exogenous miR-29s substantially inhibited the proliferation, migration and invasion of U87MG cells, and promoted their apoptosis." -genetics_overexpression_suppress hsa-mir-135a Medulloblastoma 25639612 "Remarkably, enforced expression of miR-135a in HT CSCs strongly inhibited tumorigenesis by repressing the miR-135a direct target gene Arhgef6." -genetics_overexpression_suppress hsa-mir-133a Heart Failure 25658461 transfecting MSCs with miR-133a mimic improves survival of MSCs as determined by the MTT assay. -genetics_overexpression_suppress hsa-mir-124 Osteosarcoma 25667613 "transfection of miR-124 mimic into MG63 cells was able to reduce cell proliferation, invasion and migration, and promote cell apoptosis." -genetics_overexpression_suppress hsa-mir-184 "Carcinoma, Renal Cell" 25667660 "Our studies revealed that miR-184 mimic significantly inhibits cell migration, suppresses cell proliferation and induces renal cancer cell apoptosis in vitro when compared with the negative control (P<0.05)." -genetics_overexpression_suppress hsa-mir-16 Breast Neoplasms 25672252 "Overexpression of microRNA-16 declines cellular growth, proliferation and induces apoptosis in human breast cancer cells." -genetics_overexpression_suppress hsa-mir-1 "Squamous Cell Carcinoma, Esophageal" 25672418 Downregulation of microRNA-1 in esophageal squamous cell carcinoma correlates with an advanced clinical stage and its overexpression inhibits cell migration and invasion. -genetics_overexpression_suppress hsa-mir-150 "Leukemia, Lymphoblastic, Acute" 25687053 "miR-150 may be a putative oncoprotein in T-ALL cells. Overexpression of miR-150 has noticeable effects on the proliferation inhibition and apoptosis induction of Jurkat cells, which may be mediated by the negative regulation of PI3K/Akt /NF-¦ÊB signaling pathway." -genetics_overexpression_suppress hsa-mir-21 Immune System Disease [unspecific] 25688245 miR-21 has emerged as a key mediator of the anti-inflammatory response in macrophages. -genetics_overexpression_suppress hsa-mir-203 Brain Disease [unspecific] 25723469 enforced expression of miR-203 or MyD88 siRNA silencing inhibits downstream NF-¦Ê¦Â signaling and microglia activation -genetics_overexpression_suppress hsa-mir-126 Spinal Cord Injuries 25724143 "increased levels of miR-126 promoted angiogenesis, and inhibited leukocyte extravasation into the injured spinal cord" -genetics_overexpression_suppress hsa-let-7f Glioma 25735962 "The enhanced expression of Let-7f suppressed glioma cells proliferation, migration, and invasion via direct targeting perisotin oncogenic activity." -genetics_overexpression_suppress hsa-mir-122 Liver Neoplasms 25762642 "miR-107, mir-122, miR-29, miR-365 and miR-802 exhibited weak to moderate tumor suppressor potential." -genetics_overexpression_suppress hsa-mir-210 Cerebral Ischemia 25783636 Rats treated with VNS showed increased miR-210 expression as well as decreased apoptosis and antioxidant stress responses compared with the I/R group -genetics_overexpression_suppress hsa-mir-29b Prostate Neoplasms 25784815 forced expression of miR-29b inhibited cell proliferation and cell invasion and induced cell apoptosis in PCa. -genetics_overexpression_suppress hsa-mir-184 Retinal Neovascularization 25796186 miR-184 mimic inhibits Wnt signaling in the OIR retina -genetics_overexpression_suppress hsa-mir-26a Nervous System Diseases [unspecific] 25808510 We found that miR-26a up-regulation promoted neurite outgrowth and reduced apoptosis in bupivacaine-injured DRG neurons. -genetics_overexpression_suppress hsa-mir-21 Myocardial Infarction 25809568 "In miR-21 group, myocardial infarct size reduced by 36.9% in comparison with LV-GFP group." -genetics_overexpression_suppress hsa-let-7a Breast Neoplasms 25846193 "Cell proliferation, colony formation, migration and invasion were decreased after overexpression of let-7a in breast cancer cells and vice versa." -genetics_overexpression_suppress hsa-mir-193b Adenovirus Infection 25854561 The over-expression of miR-193b may suppress the proliferation of K562 cells. -genetics_overexpression_suppress hsa-mir-206 Medulloblastoma 25859932 "MiR-206, a Cerebellum Enriched miRNA Is Downregulated in All Medulloblastoma Subgroups and Its Overexpression Is Necessary for Growth Inhibition of Medulloblastoma Cells." -genetics_overexpression_suppress hsa-mir-26a Graft-Versus-Host Disease 25865461 The prolonged allograft survival induced by LV-Mir-26a was also completely abrogated by IL-6 overexpression. -genetics_overexpression_suppress hsa-let-7a "Carcinoma, Nasopharyngeal" 25884389 "synthetic let-7a mimics suppressed NPC cells migration, invasion and EMT process and knockdown of HMGA2 was consistent with the effects of let-7a in NPC cells." -genetics_overexpression_suppress hsa-mir-146a Atherosclerosis 25904598 cellular enrichment of miR-146a through the systemic delivery of miR-146a mimetics in Apoe(-/-)Ldlr(-/-) and Ldlr(-/-) mice attenuated monocyte/macrophage activation and atherosclerosis in the absence of plasma lipid reduction. -genetics_overexpression_suppress hsa-mir-145 Malignant Neoplasms [unspecific] 25926306 "cell proliferation level of OS-732 with microRNA-145 overexpression was significantly decreased, and OS-732 cell invasion capacity was also significantly decreased" -genetics_overexpression_suppress hsa-mir-145 Prostate Neoplasms 25951106 Overexpression of miR-145-5p inhibits proliferation of prostate cancer cells and reduces SOX2 expression. -genetics_overexpression_suppress hsa-mir-133a Heart Failure 25960234 The miR-133a mimic and miR-133a overexpression significantly caused a decrease in the fibrosis of heart in chronic heart failure rats. -genetics_overexpression_suppress hsa-mir-138 "Carcinoma, Gallbladder" 25962180 Expression of miR-138 is frequently reduced in gallbladder carcinoma when compared to normal cells. Overexpression of miR-138 inhibited cell proliferation by directly suppressing the expression of Bag-1. These results suggest that miR-138 plays an important role in inhibiting the growth of gallbladder carcinoma. -genetics_overexpression_suppress hsa-mir-95 "Adenocarcinoma, Lung" 25971210 Overexpression of microRNA-95-3p suppresses brain metastasis of lung adenocarcinoma through downregulation of cyclin D1. -genetics_overexpression_suppress hsa-mir-202 Multiple Myeloma 25971527 The growth rate of miR-202 mimics transfection cells was significantly lower than that of non-transfected cells. -genetics_overexpression_suppress hsa-mir-133a Vascular Hypertrophy 25995211 delivery of miR-1 and miR-133a suppressed inducible cAMP early repressor expression and prevented both electrical remodeling and hypertrophy. -genetics_overexpression_suppress hsa-mir-100 Osteosarcoma 26018508 Overexpression of miR-100 inhibits growth of osteosarcoma through FGFR3. -genetics_overexpression_suppress hsa-mir-214 Ischemia-Reperfusion Injury 26025394 214 may participate in the protective function of ischemic post conditioning by down regulating HIF1AN. -genetics_overexpression_suppress hsa-mir-16 Sarcoma [unspecific] 26044957 "miR-16, but not other downregulated miRNAs, was able to significantly suppress both migration and invasion in vitro" -genetics_overexpression_suppress hsa-mir-146a Sepsis 26048146 In vivo transfection of LmiR-146a attenuated sepsis-induced cardiac dysfunction. -genetics_overexpression_suppress hsa-mir-506 Breast Neoplasms 26059632 "MiR-506 over-expression significantly inhibits the proliferation,colony formation, and migration of breast cancer cells. miR-506 over-expression may thus be able to improve the malignant phenotype of breast cancer cells." -genetics_overexpression_suppress hsa-mir-16 "Adenocarcinoma, Lung" 26064212 enforced expression of mir-16 lead to reduced A549 cell proliferation and promote apoptosis. -genetics_overexpression_suppress hsa-mir-195 Colorectal Carcinoma 26064276 has-miR-195 can promote cell apoptosis and inhibit the invasion and metastasis by inhibiting the expression of Bcl-2. -genetics_overexpression_suppress hsa-mir-98 Neuroinflammation 26126865 "Overexpression of let-7 and miR-98 in vitro and in vivo resulted in reduced leukocyte adhesion to and migration across endothelium, diminished expression of pro-inflammatory cytokines, and increased BBB tightness, attenuating barrier 'leakiness' in neuroinflammation conditions." -genetics_overexpression_suppress hsa-mir-138 Cardiovascular Diseases [unspecific] 26129883 over-expression of miR-138 significantly enhanced the cell growth and significantly attenuated the cell apoptosis in hypoxic conditions. -genetics_overexpression_suppress hsa-mir-29a Prostate Neoplasms 26131109 "enforced expression of miR-29a in PC-3 and LNCaP cells inhibited proliferation, and induced apoptosis by repressing the expression of KDM5B." -genetics_overexpression_suppress hsa-mir-146a Sepsis 26138422 "Up-regulation of miR-146a inhibit the release of the inflammatory cytokine TNF-α stimulated by sepsis, and alleviate inflammatory reaction and lung tissue injury in mice with sepsis-induced ALI." -genetics_overexpression_suppress hsa-mir-27b Cardiovascular Diseases [unspecific] 26161255 miR-27b mimic had overall beneficial effects -genetics_overexpression_suppress hsa-mir-573 Rheumatoid Arthritis 26166764 miR-573 overexpression suppressed the expression of interleukin 6 (IL-6) and cyclooxygenase 2 in RASFs -genetics_overexpression_suppress hsa-mir-137 Melanoma 26186482 overexpression of miR-137 inhibited the proliferation of melanoma cells -genetics_overexpression_suppress hsa-mir-34c Diabetic Nephropathy 26191142 miR-34c was downregulated and that overexpression of miR-34c inhibited HG-induced podocyte apoptosis. -genetics_overexpression_suppress hsa-mir-221 Astrocytoma 26191177 Overexpression of miR-221 inhibits proliferation and promotes apoptosis of human astrocytoma cells. -genetics_overexpression_suppress hsa-mir-23b Neoplasms [unspecific] 26198058 "miR-23b, miR-199a, and miR-15a displayed increased expression during early AVC development whereas others such as miR-130a and miR-200a display decreased expression levels" -genetics_overexpression_suppress hsa-mir-26a "Diabetes Mellitus, Type 2" 26208605 Mir-26a suppresses autoimmune diabetes in NOD mice in part through promoted regulatory T cells (Tregs) expression. -genetics_overexpression_suppress hsa-mir-140 Osteosarcoma 26219893 "relative miR-140 expression was increased, cell proliferation was inhibited, cell population in G0/G1 phase was increased, cell population in G2/M phase and S phases and proliferation index (PI), and cell migration distance were decreased in the miR-140 mimic group" -genetics_overexpression_suppress hsa-mir-210 Osteoarthritis 26244598 "Transfection with miR-210 mimic inhibited LPS-induced pro-inflammatory cytokines production, cell viability reduction and cell apoptosis." -genetics_overexpression_suppress hsa-mir-1 Vascular Hypertrophy 26253469 the administration of a miR-1 mimic attenuated cardiac hypertrophy by suppressing the transverse aortic constriction-induced increase in myocardin expression -genetics_overexpression_suppress hsa-mir-302b "Carcinoma, Hepatocellular" 26254095 Overexpression of miR-302b suppressed HCC cell invasion and metastasis. -genetics_overexpression_suppress hsa-mir-143 Prostate Neoplasms 26269764 "miR-143 has an inhibitory effect on cell proliferation as evidenced by decreased cell viability, increased cell apoptosis and cell cycle arrest at the G1/S transition." -genetics_overexpression_suppress hsa-mir-125a Colon Neoplasms 26297542 overexpression of miR-125a-5p inhibited cell proliferation and induced cell apoptosis in colon cancer cells. -genetics_overexpression_suppress hsa-mir-31 "Adenocarcinoma, Lung" 26299665 overexpression of miR-31 led to the inhibition of adenocarcinoma cell proliferation. -genetics_overexpression_suppress hsa-mir-206 "Carcinoma, Lung, Non-Small-Cell" 26309565 "Forced overexpression of miR-206 significantly inhibited cell proliferation, migration and invasion of NSCLC cells." -genetics_overexpression_suppress hsa-mir-26a Ischemia-Reperfusion Injury 26320674 Mir-26a overexpression results in attenuated cardiac IR injury and inhibited HMGB1 expression. -genetics_overexpression_suppress hsa-mir-33b Colorectal Carcinoma 26329295 miR-33b inhibited tumor cell growth and induced cell cycle arrest. -genetics_overexpression_suppress hsa-mir-9 Inflammation 26354749 "miR-9 overexpression significantly repressed NF-κB expression and, thereby, suppressed inflammation but promoted LEC tube formation" -genetics_overexpression_suppress hsa-mir-9 Spinal Cord Injuries 26359086 miR-9 overexpression promoted osteoblast differentiation and angiogenesis -genetics_overexpression_suppress hsa-mir-634 Cervical Neoplasms 26367112 "miR-634 inhibited cell proliferation, migration and invasiveness in cervical cancer cells and the block of miR-634 enhances the mTOR expression at both the mRNA and protein levels which regulated the expression of mTOR negatively." -genetics_overexpression_suppress hsa-mir-16 Glioblastoma 26373393 "Overexpression of microRNA- 16 in the A172 and U87 GBM cell lines inhibited the activities of co-cultured endothelial cells, including proliferation, migration, extension and tubule formation." -genetics_overexpression_suppress hsa-mir-145 Glioblastoma 26374689 "CSCs expressed low levels of miR-145, and its introduction decreased self-renewal through reductions in AKT signaling and stem cell marker (SOX2, OCT4, and NANOG) expression" -genetics_overexpression_suppress hsa-mir-449a Liver Neoplasms 26375440 "Overexpression of miR-449a inhibited cell proliferation, induced G1 phase arrest and cell apoptosis in liver cancer." -genetics_overexpression_suppress hsa-mir-1 Myocardial Infarction 26380976 miR-1 and -21 jointly blocked hypoxia-induced cardiomyocytes apoptosis. -genetics_overexpression_suppress hsa-mir-21 Myocardial Infarction 26380976 miR-1 and -21 jointly blocked hypoxia-induced cardiomyocytes apoptosis. -genetics_overexpression_suppress hsa-mir-16 "Carcinoma, Nasopharyngeal" 26383521 "we identified upregulation of tumor suppressor miR-16a, which inhibited cell cycle progression and sensitized NPC cells to chemotherapy." -genetics_overexpression_suppress hsa-mir-221 Ischemia-Reperfusion Injury 26396139 "Mimics of miRNA-221, -150, and -206 were protective in both H9c2 and NRVM." -genetics_overexpression_suppress hsa-mir-133a "Cardiomyopathy, Hypertrophic" 26403739 miR-133a is an important regulator of phenylephrine-induced cardiomyocyte hypertrophy and negatively regulates this process. -genetics_overexpression_suppress hsa-mir-7 Adrenal Cortex Neoplasms 26452132 microRNA-7-5p (miR-7) reduces cell proliferation in vitro and induces G1 cell cycle arrest. -genetics_overexpression_suppress hsa-mir-125b Cholangiocarcinoma 26455324 "We also found that enforced expression of let-7c, miR-99a or miR-125b could reduce the activity of STAT3 and further suppress CCA tumorigenicity in vivo and inhibit the migration and invasion of CCA cells in vitro." -genetics_overexpression_suppress hsa-mir-34a Alzheimer Disease 26459758 "Importantly, the overexpression of TAp73α and miR-34a reversed cell cycle-related neuronal apoptosis (CRNA)." -genetics_overexpression_suppress hsa-mir-140 Rheumatoid Arthritis 26473405 "Overexpression of miRNAs 140-3p and 140-5p caused a reduction in expression, with correlated kinetic patterns, of their corresponding target molecules sirtuin 1 and stromal cell-derived factor 1 in the SFs and joints of mice." -genetics_overexpression_suppress hsa-mir-29a "Carcinoma, Thyroid, Papillary" 26482618 "overexpression of miR-29a markedly suppressed PTC cell proliferation, migration, and invasion and promoted PTC apoptosis and cell cycle arrest at G0/G1 phase." -genetics_overexpression_suppress hsa-mir-29c "Carcinoma, Embryonal" 26484393 MicroRNA-29c overexpression inhibits proliferation and promotes apoptosis and differentiation in P19 embryonal carcinoma cells. -genetics_overexpression_suppress hsa-mir-26a "Carcinoma, Lung, Non-Small-Cell" 26492332 "Overexpression of miR-26a in A549 cells inhibited G1-S transition, increased cell death in response to CDDP treatment, and decreased the colony formation of A549 cells." -genetics_overexpression_suppress hsa-mir-214 "Carcinoma, Hepatocellular" 26498144 Overexpression of miR-214 in HCC cells inhibited proliferation by inducing G1-S checkpoint arrest. -genetics_overexpression_suppress hsa-mir-138 Laryngeal Neoplasms 26499780 "miR-138 overexpression inhibited ZEB2-mediated cell invasiveness, while miR-138 depletion increased ZEB2-mediated cell invasiveness in LC cells." -genetics_overexpression_suppress hsa-mir-16 "Carcinoma, Hepatocellular" 26499886 "The results of this study suggest that the overexpression of miR-16 inhibits the proliferation, invasion and metastasis of HepG2 HCC cells, and that these effects are associated with the PI3K/Akt signaling pathway." -genetics_overexpression_suppress hsa-mir-152 Cervical Neoplasms 26515145 Overexpression of miR-152 repressed WNT1 and ERBB3 expression and decreased proliferation of HeLa cells. -genetics_overexpression_suppress hsa-mir-222 "Squamous Cell Carcinoma, Tongue" 26517090 "Moreover, miR-222 mimics and ABCG2 siRNA inhibited tumor growth and lung metastasis in vivo." -genetics_overexpression_suppress hsa-mir-449a Prostate Neoplasms 26520443 "Overexpression of miR-449a induces cell cycle arrest, apoptosis, and senescence" -genetics_overexpression_suppress hsa-mir-205 "Carcinoma, Skin" 26527515 "Ectopic expression of miR-205-5p in spindle cancer cells reduces Rap1a, mitigates cell invasiveness, decreases proliferation, and delays tumor onset." -genetics_overexpression_suppress hsa-mir-195 Thyroid Neoplasms 26527888 exogenous overexpression of miR-195 significantly inhibits the protein expression of Raf1 and blocks the thyroid cancer cell proliferation. -genetics_overexpression_suppress hsa-let-7b Myocardial Ischemic-Reperfusion Injury 26542107 intramyocardial injection of let-7b-modified MSCs significantly enhanced ventricular function and facilitated myocardial repair by protecting transplanted cells from apoptosis and autophagy in the rat cardiac ischemia-reperfusion model. -genetics_overexpression_suppress hsa-mir-363 Head And Neck Neoplasms 26545583 "These findings demonstrate that the overexpression of miR-363 reduces cellular migration in head and neck cancer and reveal the biological relationship between miR-363, myosin 1b, and HPV-positive SCCHN." -genetics_overexpression_suppress hsa-mir-150 Osteosarcoma 26561465 "restoration of miR-150 expression in OS cells could inhibit cell proliferation, migration, and invasion and induced apoptosis in vitro as well as suppressed tumor growth of OS in vivo." -genetics_overexpression_suppress hsa-mir-7-1 Glioblastoma 26573275 "In conclusion, our results clearly demonstrated that overexpression of miR-7-1-3p augmented the anti-tumor activities of LUT and SIL to inhibit autophagy and induce apoptosis for controlling growth of different human glioblastomas in vivo." -genetics_overexpression_suppress hsa-mir-15a "Carcinoma, Hepatocellular" 26581909 "Ectopic overexpression of miR-15a-5p suppressed cancer proliferation, induced cell cycle arrest in HepG2 or SNU-182 cells in vitro, and inhibited HCC tumor growth in vivo." -genetics_overexpression_suppress hsa-mir-16 Alzheimer Disease 26592823 Overexpression and inhibition of miR-16 in the cellular AD model with primary hippocampal neurons decreased and increased apoptosis -genetics_overexpression_suppress hsa-mir-125b Melanoma 26596831 Restored expression of miR-125b in melanoma suppressed cell proliferation and invasion both in vitro and in vivo. -genetics_overexpression_suppress hsa-mir-100 Ovarian Neoplasms 26607088 The expression of miR-100 is downregulated in SKOV3/DDP cells.Overexpressing miR-100 may effectively increase the sensitivity to cisplatin of human ovarian epithelial cancer SKOV3/DDP cells and may reverse cisplatin-resistance of EOC (epithelial ovarian cancer). -genetics_overexpression_suppress hsa-mir-145 "Carcinoma, Hepatocellular" 26615424 "Overexpression of miR-145 in HCC cell lines significantly inhibited cell proliferation, migration, and invasion in vitro." -genetics_overexpression_suppress hsa-mir-143 Breast Neoplasms 26618772 "Up-regulating miR-143 enhanced E-cadherin-mediated cell-cell adhesion ability, reduced mesenchymal markers, and decreased cell proliferation, migration, and invasion in vitro." -genetics_overexpression_suppress hsa-mir-18a "Carcinoma, Gastric" 26622381 The results showed that miR-18a overexpression was able to promote cell apoptosis and inhibit cell invasion. -genetics_overexpression_suppress hsa-mir-182 Glioma 26622652 "overexpression of miR-182 affected cell cycle regulation and cell migration capacity in vitro, which may have been associated with the promotion of apoptosis by this molecule." -genetics_overexpression_suppress hsa-mir-195 Cervical Neoplasms 26622903 "The expression of miR-195 mimics in the cervical cancer HeLa cell line significantly decreased the cell proliferation, migration and invasion capacities in vitro." -genetics_overexpression_suppress hsa-mir-302b Breast Neoplasms 26623722 "miR-302b overexpression enhances sensitivity to cisplatin in breast cancer cell lines, reducing cell viability and proliferation in response to the treatment." -genetics_overexpression_suppress hsa-mir-195 Cervical Neoplasms 26631043 overexpression of miR-195 played a suppressor role in the proliferation of HeLa and SiHa cells and promoted cell apoptosis. -genetics_overexpression_suppress hsa-mir-195 Breast Neoplasms 26632252 "ectopic expression of hsa-miR-195 in MCF-7 and MDA-MB-231 cells not only altered cellular cholesterol and triglyceride levels significantly but also resulted in reduced proliferation, invasion and migration." -genetics_overexpression_suppress hsa-mir-1 Cardiomegaly 26638879 miRNA-1 overexpression prevented cardiomyocyte hypertrophy. -genetics_overexpression_suppress hsa-mir-16 "Lymphoma, Non-Hodgkin" 26640145 The miR-16 transfection significantly decreased senescent cells and increased apoptotic cells -genetics_overexpression_suppress hsa-mir-16 "Lymphoma, T-Cell, Cutaneous" 26640145 The miR-16 transfection significantly decreased senescent cells and increased apoptotic cells -genetics_overexpression_suppress hsa-mir-16 "Carcinoma, Nasopharyngeal" 26655091 "Ectopic expression of miR-16 suppressed NPC cell proliferation, migration, and invasion in vitro and inhibited tumor growth and metastatic colonization in the lung in vivo." -genetics_overexpression_suppress hsa-mir-372 "Carcinoma, Endometrial" 26673619 miR-372 overexpression suppressed tumor growth -genetics_overexpression_suppress hsa-mir-222 Osteoarthritis 26673737 Over-expression of miR-222 significantly suppressed apoptotic death by down-regulating HDAC-4 and MMP-13 level. -genetics_overexpression_suppress hsa-mir-30a "Carcinoma, Ovarian" 26675258 "Overexpression of miR-30a decreased Akt and mitogen activated protein kinase signaling pathway activation, cell proliferation, invasion, plasticity, EMT marker levels, and vascular endothelial growth factor release." -genetics_overexpression_suppress hsa-mir-215 Ovarian Neoplasms 26676658 "Upregulation of miR-215 inhibited cell proliferation, promoted apoptosis and increased sensitivity to chemotherapy drugs in EOC cells." -genetics_overexpression_suppress hsa-mir-192 "Carcinoma, Hepatocellular" 26684241 miR-192 significantly suppressed metastasis of HCC cells in vitro and in vivo. -genetics_overexpression_suppress hsa-mir-181d "Squamous Cell Carcinoma, Oral" 26693182 Ectopic expression of miR-181a/d decreased anchorage independent growth and CSC phenotype of HPV16-transfected OSCC. -genetics_overexpression_suppress hsa-mir-494 "Carcinoma, Ovarian" 26695144 "overexpression of miR-494 in EOC cells could remarkably inhibit proliferation, colony formation, migration, and invasion and induce cell apoptosis, G0/G1 phase arrest." -genetics_overexpression_suppress hsa-mir-1 "Cardiomyopathy, Hypertrophic" 26699910 "miR-1 mimic, in parallel to CDK6 siRNA, could inhibit PE-induced hypertrophy of NRVCs, with decreases in cell size" -genetics_overexpression_suppress hsa-mir-148a Breast Neoplasms 26707142 The ectopic miR-148a expression inhibited the migration and invasion of MCF-7 and MDA-MB-231 breast cancer cells. -genetics_overexpression_suppress hsa-mir-145 Breast Neoplasms 26715279 "Overexpression of miR-145 in MCF-7 and BT-549 cell lines significantly inhibited cell proliferation, migration, and invasion in vitro." -genetics_overexpression_suppress hsa-mir-206 "Carcinoma, Renal Cell, Clear-Cell" 26718123 "upregulation of miR-206 inhibited renal cancer cell proliferation, invasion and migration" -genetics_overexpression_suppress hsa-mir-452 "Carcinoma, Lung, Non-Small-Cell" 26718215 "xpression of miR-452 via adenoviral (Ad) vector inhibits the proliferation, invasion, and migration of NSCLC cells A549 or H460." -genetics_overexpression_suppress hsa-mir-143 Prostate Neoplasms 26721309 miR-143 restoration decreased secreted MMP-2 and MMP-9 enzyme activities compared with scramble controls -genetics_overexpression_suppress hsa-mir-34c "Carcinoma, Hepatocellular, HBV-Related" 26722295 "The restoration of miR-34c in HepG2.2.15 cells suppressed TGIF2 expression, HBV replication and viral antigen synthesis; inhibited cell proliferation; and induced apoptosis." -genetics_overexpression_suppress hsa-mir-34a Prostate Neoplasms 26722316 The over-expression of miR-34a inhibited PC-3 cells growth and resulted in increased cell cycle arrest compared with the negative control (P<0.05). -genetics_overexpression_suppress hsa-mir-145 "Carcinoma, Breast, Triple Negative" 26733177 tumor necrosis factor-alpha (TNF-α)-induced apoptosis was expanded by the transfection of miR-145 in MDA-MB-231 which belongs to the TNBC cell lines. -genetics_overexpression_suppress hsa-mir-488 Gastric Neoplasms 26738864 "The ectopic expression of miR-488 suppressed the GC cell proliferation, cell cycle, colony information, and migration." -genetics_overexpression_suppress hsa-mir-125b Osteosarcoma 26744308 "stable overexpression of miR-125b in osteosarcoma cell lines U2OS and MG-63 inhibited cell proliferation, migration, and invasion." -genetics_overexpression_suppress hsa-let-7 Gastric Neoplasms 26745603 "overexpression of miR-let-7a markedly suppressed the proliferation, migration, and invasion of GC cells by down-regulating the expression of PKM2." -genetics_overexpression_suppress hsa-mir-23b Asthma 26748386 Overexpression of miR-23b significantly inhibited TGF-β1-induced ASMCs proliferation and promoted apoptosis. -genetics_overexpression_suppress hsa-mir-378 Breast Neoplasms 26749280 "ectopic expression of miR-378 in MDA-MB-231 cells inhibited Runx1 and suppressed migration and invasion, while inhibition of miR-378 in MCF7 cells increased Runx1 levels and cell migration." -genetics_overexpression_suppress hsa-let-7f Glioma 26750768 inhibiting the pro-migratory function of POSTN by the overexpression of miR-Let-7f significantly reduced the formation of VM. -genetics_overexpression_suppress hsa-mir-320 Cervical Neoplasms 26753959 "miR-320 induces apoptosis via down-regulation of Mcl-1 and activation of caspase-3 but inhibits cell proliferation, migration, invasion, and tumorigenesis in cervical cancer cells." -genetics_overexpression_suppress hsa-mir-340 Breast Neoplasms 26758430 miR-340 could dramatically down-regulate metastasis by targeting Wnt signaling in breast cancer cells. -genetics_overexpression_suppress hsa-mir-143 "Squamous Cell Carcinoma, Esophageal" 26758433 "miR-143 exerted a tumor-suppressing effect by inhibiting the proliferation, migration, and invasion and inducing G1/G0 phase arrest of ESCC cells via the negative regulation of FAM83F expression." -genetics_overexpression_suppress hsa-mir-381 Ovarian Neoplasms 26768613 "Overexpression of miR-381 significantly inhibited EOC cell proliferation, migration, and invasion." -genetics_overexpression_suppress hsa-mir-503 Osteosarcoma 26768615 miR-503 overexpression suppressed cell invasion and migration and inhibited epithelial-to-mesenchymal transition (EMT) of MG-63. -genetics_overexpression_suppress hsa-mir-29a Multiple Myeloma 26771839 "In addition, ectopic expression of miRNA-29a or exposure to PRIMA-1Met reduced cell proliferation and induced apoptosis in MM cells." -genetics_overexpression_suppress hsa-mir-30a "Carcinoma, Urothelial" 26775686 Both miR-30a and small interfering RNA Notch1 negatively regulated cell proliferation -genetics_overexpression_suppress hsa-mir-210 Hypoxia 26780211 miR-210 upregulation exerted amelioration on the hypoxia-induced apoptosis -genetics_overexpression_suppress hsa-mir-27b Gastric Neoplasms 26780940 miR-27b overexpression significantly inhibited H. pylori infection-induced cell proliferation and WNT signaling pathway activation in gastric cancer cells. -genetics_overexpression_suppress hsa-mir-20a "Squamous Cell Carcinoma, Oral" 26781875 "Upregulation of miR-20a by transfected plasmid HPV-16 E7 can significantly inhibit Cal27 cell proliferation, invasion, and migration." -genetics_overexpression_suppress hsa-mir-214 "Carcinoma, Hepatocellular" 26788207 enhanced expression of miR-214 or silencing of E2F3 inhibited the proliferation of HCC SMMC-7721 cells. -genetics_overexpression_suppress hsa-mir-382 Colorectal Carcinoma 26800338 "Transfection with miR-382 mimics impeded the growth, migration, and invasion of CRC cells." -genetics_overexpression_suppress hsa-mir-125b Bladder Neoplasms 26807182 "Overexpression of miR-125b inhibited cellular growth, suppressed cellular migration and caused an accumulation of cells in the G1 phase of the cell cycle" -genetics_overexpression_suppress hsa-mir-152 Colorectal Carcinoma 26820128 restoring the expression of miR-152 in CRC cells dramatically reduced the cell proliferation and cell migration and invasion and promoted apoptosis -genetics_overexpression_suppress hsa-mir-451 Rheumatoid Arthritis 26823778 miR-451 treatment significantly decreased cell proliferation ability -genetics_overexpression_suppress hsa-mir-30a "Adenocarcinoma, Lung" 26837415 overexpression of miR-30a in A549 cells inhibited migration and invasion but not cell proliferation and cell cycle progression -genetics_overexpression_suppress hsa-mir-137 Gastric Neoplasms 26840256 Overexpression of miR-9 and miR-137 downregulated the CUL4A-LATS1-Hippo signaling pathway and suppressed GC cell proliferation and invasion in vitro. -genetics_overexpression_suppress hsa-mir-9 Gastric Neoplasms 26840256 Overexpression of miR-9 and miR-137 downregulated the CUL4A-LATS1-Hippo signaling pathway and suppressed GC cell proliferation and invasion in vitro. -genetics_overexpression_suppress hsa-mir-21 Ischemia 26841045 over-expressing miR-21 in UCBMSCs could improve neovascularization in CLI -genetics_overexpression_suppress hsa-mir-448 Gastric Neoplasms 26852749 "Ectopic expression of miR-448 suppressed GC cell proliferation, colony formation, and invasion." -genetics_overexpression_suppress hsa-mir-200b Endometriosis 26854065 "up-regulation of miR-200b reverts EMT, emerging as a potential therapeutic approach to inhibit endometriotic cell motility and invasiveness." -genetics_overexpression_suppress hsa-mir-373 Glioma 26858153 "although miR-373 does not affect cell growth of U251, it inhibits migration and invasion of U251." -genetics_overexpression_suppress hsa-mir-144 "Lymphoma, Large B-Cell" 26865454 "forced expression of miR-144 significantly attenuated cell proliferation and invasion of OCI-Ly3 cells in vitro, and the tumor-suppressor effect of miR-144 was also confirmed using a xenograft mouse model in vivo Taken together" -genetics_overexpression_suppress hsa-mir-150 "Carcinoma, Hepatocellular" 26871477 "miR-150 overexpression inhibited cell proliferation, migration and invasion in vitro and tumor growth and metastasis in vivo." -genetics_overexpression_suppress hsa-mir-19a Lung Fibrosis 26873752 "intratracheal application of miR-19a, -19b, and 26b reduced the pulmonary fibrotic severity induced by bleomycin" -genetics_overexpression_suppress hsa-mir-19b Lung Fibrosis 26873752 "intratracheal application of miR-19a, -19b, and 26b reduced the pulmonary fibrotic severity induced by bleomycin" -genetics_overexpression_suppress hsa-mir-26b Lung Fibrosis 26873752 "intratracheal application of miR-19a, -19b, and 26b reduced the pulmonary fibrotic severity induced by bleomycin" -genetics_overexpression_suppress hsa-mir-223 Breast Neoplasms 26876200 both RT-induced miR-223 and peri-operative inhibition of EGFR efficiently prevented BC cell growth and reduced recurrence formation in mouse models of BC. -genetics_overexpression_suppress hsa-mir-203 "Squamous Cell Carcinoma, Head and Neck" 26882562 "oreover, ectopic overexpression of miR-203 suppressed the invasion and induced mesenchymal-epithelial transition (MET) in HNSCC cells." -genetics_overexpression_suppress hsa-mir-451 "Carcinoma, Renal Cell" 26884830 "microRNA-451 inhibited proliferation, migration and invasion of renal cell carcinomas cells." -genetics_overexpression_suppress hsa-mir-15b Liver Neoplasms 26884837 MiR-15b mimic transfection promoted miR-15b overexpression and inhibited HepG2 cell proliferation significantly -genetics_overexpression_suppress hsa-mir-26b "Carcinoma, Hepatocellular" 26891666 miR-26b-5p inhibited HCC cell growth and impaired the tube formation ability of the HCC cells -genetics_overexpression_suppress hsa-mir-15a Gastric Neoplasms 26894855 ectopic expression of miR-15a decreased Bmi-1 in gastric cancer cell lines with reduced proliferation and tumor invasion. -genetics_overexpression_suppress hsa-mir-23b Prostate Neoplasms 26898757 miR-23b/-27b expression in prostate cancer cells decreased seminal vesicle invasion and distant metastases -genetics_overexpression_suppress hsa-mir-27b Prostate Neoplasms 26898757 miR-23b/-27b expression in prostate cancer cells decreased seminal vesicle invasion and distant metastases -genetics_overexpression_suppress hsa-mir-99a Cardiovascular Diseases [unspecific] 26914935 Overexpression of microRNA-99a Attenuates Cardiac Hypertrophy. -genetics_overexpression_suppress hsa-mir-146a Glioblastoma 26916895 The upregulation of miR-146a in glioma cells through miR-146a mimic transfection led to reduction of cell viability and to an increase in the percentage of apoptosis. -genetics_overexpression_suppress hsa-mir-19b Myocardial Ischemic-Reperfusion Injury 26918829 we found that overexpression of miR-19b decreased H2O2-induced apoptosis and improved cell survival -genetics_overexpression_suppress hsa-mir-200b "Carcinoma, Hepatocellular" 26919246 "Forced expression of microRNA-200b in HCC cells dramatically repressed proliferation, colony formation, cell cycle progression, and invasion." -genetics_overexpression_suppress hsa-mir-24 "Carcinoma, Nasopharyngeal" 26922862 cell proliferation was suppressed and radiosensitivity increased when miR-24 was ectopically expressed in NPC cells. -genetics_overexpression_suppress hsa-mir-34b Osteosarcoma 26924291 Upregulation of miR-34b also induced apoptosis and increased the sensitivity of the cells to the anticancer drugs -genetics_overexpression_suppress hsa-mir-372 Gastric Neoplasms 26928593 inhibit proliferations of adenocarcinoma gastric cancer (AGS) cells overexpressing these miRNAs -genetics_overexpression_suppress hsa-mir-27a Endometrial Neoplasms 26934121 Enforced expression of miR-124 suppresses EC cell invasion and proliferation. -genetics_overexpression_suppress hsa-mir-204 "Carcinoma, Lung, Non-Small-Cell" 26935060 "Transient over-expression of miR-204 by transfecting with miR-204 mimics suppressed NSCLC cell proliferation, migration, and induced apoptosis and G1 arrest" -genetics_overexpression_suppress hsa-mir-200b "Carcinoma, Cervical" 26935156 miRâ€?00b suppressed the migratory potential of cervical carcinoma cells -genetics_overexpression_suppress hsa-mir-200c "Carcinoma, Lung, Non-Small-Cell" 26935975 Overexpression of miRâ€?00c significantly suppressed cell migration and invasion of A549 NSCLC cells. -genetics_overexpression_suppress hsa-mir-141 Neuroblastoma 26936280 "lentivirus-induced miR-141 upregulation inhibited cancer proliferation, cell cycle progression, migration and increased cisplatin chemosensitivity in vitro." -genetics_overexpression_suppress hsa-mir-181a "Lymphoma, Large B-Cell" 26941399 "miR-181a decreases DLBCL tumor cell proliferation and survival, and anti-miR-181a abrogates these effects." -genetics_overexpression_suppress hsa-mir-21 Acute Myocardial Infarction 26978580 combination of miR-21 and miR-146a has a greater protective effect against cardiac ischemia/hypoxia-induced apoptosis -genetics_overexpression_suppress hsa-mir-1 Colorectal Carcinoma 26980745 The ectopic expression of these miRs induced growth suppression and autophagic cell death -genetics_overexpression_suppress hsa-mir-200b "Carcinoma, Hepatocellular" 26986232 "Upregulated miRâ€?00b expression in HepG2 cells led to a decrease in DNMT3a expression levels, and an inhibition of cell proliferation." -genetics_overexpression_suppress hsa-mir-508 Glioma 27003587 over-expression of miR-508-5p was found to decrease glioma cell growth. -genetics_overexpression_suppress hsa-mir-7 Parkinson Disease 27003614 The upregulation of miR-7 promoted cell viability and suppressed cell apoptosis in MPP(+)-treated SH-SY5Y cells. -genetics_overexpression_suppress hsa-mir-182 Ischemic Diseases [unspecific] 27008992 Both exogenous miR-182 and Kenpaullone significantly suppressed hypoxia-induced cardiomyocyte death in vitro. -genetics_overexpression_suppress hsa-mir-134 Glioma 27012554 upregulated miR-134 expression restrained the proliferation and invasion of U251 cells in vitro. -genetics_overexpression_suppress hsa-mir-154 Glioblastoma 27013470 overexpression of miR-154 suppressed cell migration and invasion of U87 and U251 cells. -genetics_overexpression_suppress hsa-mir-20a Liver Diseases [unspecific] 27019188 miR-20a-5p mimic could reverse high glucose-induced impaired glycogenesis and AKT/GSK activation in NCTC1469 and Hep1-6 cells. -genetics_overexpression_suppress hsa-mir-490 Colorectal Carcinoma 27037061 miR-490-3p suppresses cancer cell proliferation by inducing apoptosis -genetics_overexpression_suppress hsa-let-7 "Carcinoma, Salivary Adenoid Cystic" 27042128 "the overexpression of miR-98 in ACC-M cells inhibited cell proliferation, invasion, and migration in vitro." -genetics_overexpression_suppress hsa-mir-130b Ovarian Neoplasms 27048832 overexpression of miR-130b reduced the expression of RUNX3 and inhibited cancer cell migration and invasion of EOC cells -genetics_overexpression_suppress hsa-mir-206 Muscle Atrophy 27054781 Injection of miR-206 (30 μg/rat) attenuated morphological and physiological deterioration of muscle characteristics -genetics_overexpression_suppress hsa-mir-429 Bladder Neoplasms 27058893 Exogenous mimic of miR-429 treatment dramatically inhibited the migratory ability of T24 cells. -genetics_overexpression_suppress hsa-mir-221 Neuropathic Pain 27059231 "Intrathecal injection of a miR-221 inhibitor attenuated CCI-induced mechanical allodynia and thermal hyperalgesia, and reduced proinflammatory cytokine expression" -genetics_overexpression_suppress hsa-mir-29a Endomyocardial Fibrosis 27060017 over-expression of miRNA-29a suppresses cardiac fibroblasts proliferation. -genetics_overexpression_suppress hsa-mir-506 Pancreatic Neoplasms 27065335 "miR-506 inhibited cell proliferation, induced cell cycle arrest at the G1/S transition and enhanced apoptosis and chemosensitivity of pancreatic cancer cells." -genetics_overexpression_suppress hsa-mir-101 Osteosarcoma 27073439 "Independent inhibition of c-FOS and overexpression of miR-101 expression levels significantly suppressed U2OS cell proliferation, migration and invasion (P<0.01)." -genetics_overexpression_suppress hsa-mir-124 "Carcinoma, Lung, Non-Small-Cell" 27073840 Overexpression of miR-124 apparently suppressed the proliferation and invasion of NSCLC cell lines in vitro. -genetics_overexpression_suppress hsa-mir-154 Prostate Neoplasms 27074041 "The forced expression of miR-154-5p or E2F5 knockdown significantly restrained cell growth, as well as the migratory and invasive capabilities." -genetics_overexpression_suppress hsa-mir-502 Breast Neoplasms 27080302 "Treatment with miR-502 or downregulation of SET8 suppressed cell proliferation and cell cycle, and reduced cell migration, invasion and EMT." -genetics_overexpression_suppress hsa-mir-15b Glioma 27082313 "Furthermore, miRâ€?5b inhibited proliferation and invasion, and promoted apoptosis of glioma cells while downregulating the expression of MMPâ€? and MMPâ€?." -genetics_overexpression_suppress hsa-mir-199a Breast Neoplasms 27094578 "Overexpression of miR-199a-5p reduced the mRNA and protein levels of Ets-1 in MCF-7 and MDA-MB-231 cells, whereas anti-miR-199a-5p elevated Ets-1." -genetics_overexpression_suppress hsa-mir-125a Retinoblastoma 27094723 The overexpression of miR-125a-5p significantly suppressed cell proliferation and tumor formation in retinoblastoma. -genetics_overexpression_suppress hsa-mir-138 Osteosarcoma 27095063 "miR-138 inhibited cell proliferation and invasion, and promoted cell apoptosis of human osteosarcoma cells." -genetics_overexpression_suppress hsa-mir-542 Melanoma 27107696 "Exogenous expression of miR-542-3p resulted in marked inhibition of melanoma cell migration, invasion and epithelial-mesenchymal transition (EMT) in vitro and lung metastasis in vivo." -genetics_overexpression_suppress hsa-mir-34a Lung Neoplasms 27109632 Systemic and local injection of ghR-form miR-34a (ghR-34a) suppressed tumor growth in a mouse model of RAS-induced lung cancer. -genetics_overexpression_suppress hsa-mir-130b Lupus Nephritis 27111096 overexpressing miR-130b suppressed signaling downstream from the type I IFN pathway in RMCs by targeting IFN regulatory factor 1 (IRF-1). -genetics_overexpression_suppress hsa-mir-1180 Bladder Neoplasms 27112784 miR-1180-5p also suppressed the tumor growth in vivo significantly -genetics_overexpression_suppress hsa-mir-9 Schizophrenia 27117414 "Overexpression of miR-9 was sufficient to ameliorate a previously reported neural migration deficit in SZ NPCs, whereas knockdown partially phenocopied aberrant migration in control NPCs." -genetics_overexpression_suppress hsa-mir-182 Osteosarcoma 27123060 "upregulation of miRNA-182 promotes cell apoptosis and inhibits cell viability, proliferation, invasion and migration." -genetics_overexpression_suppress hsa-let-7i "Carcinoma, Hepatocellular" 27126374 "Let-7i was downregulated in HCC tissues, and transfection of HuH-7 with let-7i inhibited malignant cell behaviors and decreased IGF2BPs transcripts." -genetics_overexpression_suppress hsa-mir-214 "Carcinoma, Hepatocellular" 27129291 Overexpression of miR-214 significantly attenuated cell proliferation. -genetics_overexpression_suppress hsa-mir-429 Cervical Neoplasms 27133071 "miR-429 over-expression and inhibition on cell elongation, migration, stress fiber formation, and invasion." -genetics_overexpression_suppress hsa-mir-370 Glioma 27138069 Overexpression of miR-370-3p showed a significant inhibitory effect on cell proliferation and accompanied cell cycle G0/G1 arrest in U251 and U87-MG cells. -genetics_overexpression_suppress hsa-mir-199b Colorectal Carcinoma 27145368 restoration of miR-199b considerably reduced cell invasion and migration in vitro and in vivo -genetics_overexpression_suppress hsa-mir-223 Inflammation 27148749 The overexpression of miR-223 in both J774A.1 and peritoneal macrophages induced a phenotypic change from M1 to M2 state -genetics_overexpression_suppress hsa-mir-133a Glioma 27154818 "Transfection of miR-150-5p or miR-133a mimics into glioma cell lines reduced MT1-MMP expression and MMP-2 activation by these cells, and cell proliferation and invasion/migration were also suppressed by it." -genetics_overexpression_suppress hsa-mir-150 Glioma 27154818 "Transfection of miR-150-5p or miR-133a mimics into glioma cell lines reduced MT1-MMP expression and MMP-2 activation by these cells, and cell proliferation and invasion/migration were also suppressed by it." -genetics_overexpression_suppress hsa-mir-140 Biliary Tract Neoplasms 27155525 Ectopic expression of miR-140-5p markedly decreased SEPT2 protein concentration in BTC cells and suppressed cell proliferation and colony formation in vitro. -genetics_overexpression_suppress hsa-mir-130a "Leukemia, Myeloid, Chronic" 27158382 over-expression of miR-130a in A562 CML cells dramatically suppresses cell proliferation and induces cell apoptosis both in vitro and in vivo. -genetics_overexpression_suppress hsa-mir-26a Ovarian Neoplasms 27158389 over-expression could significantly inhibit the proliferation of ovarian cancer cells and induce their apoptosis. -genetics_overexpression_suppress hsa-mir-1 "Squamous Cell Carcinoma, Head and Neck" 27169691 miR-1 and miR-206 significantly inhibited HNSCC cells' aggressiveness. -genetics_overexpression_suppress hsa-mir-206 "Squamous Cell Carcinoma, Head and Neck" 27169691 restoration of miR-1 and miR-206 significantly inhibited HNSCC cells' aggressiveness. -genetics_overexpression_suppress hsa-mir-196a "Carcinoma, Renal Cell" 27175581 "miRâ€?96a suppressed cell proliferation, apoptosis and migration of the 786‑O and ACHN RCC cell lines." -genetics_overexpression_suppress hsa-mir-195 Prostate Neoplasms 27175617 "miR-195 overexpression inhibited cell proliferation, cell cycle progression and tumorigenesis via directly targeting HMGA1." -genetics_overexpression_suppress hsa-mir-126 Thyroid Neoplasms 27175968 "upregulation of miRâ€?26 inhibited cell proliferation, migration and invasion in thyroid cancer cells." -genetics_overexpression_suppress hsa-mir-34a Glioma 27176117 "Overexpression of miRâ€?4a inhibited proliferation, and induced apoptosis of U87 cells." -genetics_overexpression_suppress hsa-mir-497 Osteosarcoma 27176490 "upregulation of miRâ€?97 inhibited cell proliferation, migration and invasion in osteosarcoma cell lines" -genetics_overexpression_suppress hsa-mir-223 "Carcinoma, Lung, Non-Small-Cell" 27177336 "The overexpression of miRâ€?23 may partially reverse the acquired resistance to epidermal growth factor receptor-TKIs, thus, providing a potential therapeutic strategy for TKI-resistant NSCLC." -genetics_overexpression_suppress hsa-mir-191 "Carcinoma, Lung, Non-Small-Cell" 27178817 cell proliferation was notably reduced by the miR-1908 mimic transfection -genetics_overexpression_suppress hsa-mir-126 Atherosclerosis 27180261 miR-126 up-regulation activates EPCs and ECs and contributes to vascular healing and neovessel formation -genetics_overexpression_suppress hsa-mir-328 Cervical Neoplasms 27181358 Enforced expression of miR-328 led to a decline in the expression of endogenous TCF7L2 in cervical cancer cells. -genetics_overexpression_suppress hsa-mir-448 "Squamous Cell Carcinoma, Oral" 27184799 Knockdown of N4BP2L1 and upregulation of miR-448 significantly reduced the invasive potential of oral squamous cell carcinoma cells. -genetics_overexpression_suppress hsa-mir-544 "Carcinoma, Breast, Triple Negative" 27186677 "overexpression of miR-544 in triple negative breast cancer cells significantly down-regulated expressions of Bcl6 and Stat3, which in turn severely inhibited cancer cell proliferation, migration and invasion in vitro." -genetics_overexpression_suppress hsa-mir-145 Ovarian Neoplasms 27191261 Activating miR-145 suppresses ovarian tumor growth and metastasis -genetics_overexpression_suppress hsa-let-7c Kidney Injury 27203438 miR-let7c-MSC therapy attenuated kidney injury -genetics_overexpression_suppress hsa-mir-30a Gastric Neoplasms 27208176 forced miR-30a over-expression in cancer cells can be a potential way to inhibit tumour development. -genetics_overexpression_suppress hsa-mir-320a Prostate Neoplasms 27212625 Restoration of mature miRâ€?20a in PCa cell lines showed that miRâ€?20a significantly inhibited cancer cell migration and invasion. -genetics_overexpression_suppress hsa-mir-320 Prostate Neoplasms 27216188 An miR-320a mimic suppressed AR protein expression together with growth suppression -genetics_overexpression_suppress hsa-mir-192 "Adenocarcinoma, Pancreatic Ductal" 27216198 overexpression of miR-192 was sufficient to reduce cell proliferation and invasion. -genetics_overexpression_suppress hsa-mir-150 Atherosclerosis 27216461 The suppressive effects of miR-150 on macrophage foam cell formation are mediated through targeting of AdipoR2. -genetics_overexpression_suppress hsa-mir-19a Hypoxia 27220268 miR-19a overexpression clearly ameliorated hypoxia-induced cell death (necrosis and apoptosis) -genetics_overexpression_suppress hsa-mir-34a "Carcinoma, Laryngeal" 27220728 expression of miR-34a inhibited cell proliferation and migration in laryngeal carcinoma cells. -genetics_overexpression_suppress hsa-mir-495 Glioma 27220777 restoration of hsa-miR-495 inhibited glioma cell proliferation and invasion in vitro. -genetics_overexpression_suppress hsa-mir-18b Melanoma 27220837 Ectopic expression of miR-18b decreased the proliferation of A375 and B16 cells -genetics_overexpression_suppress hsa-mir-874 Colorectal Carcinoma 27221209 expression of miR-874 was downregulated in CRC tissues and cell lines -genetics_overexpression_suppress hsa-mir-410 Breast Neoplasms 27221455 "miR-410-3p overexpression reduced cell growth, colony formation and the number of EdU-positive cells in the MDA-MB-231 cells." -genetics_overexpression_suppress hsa-mir-181a Cardiomegaly 27221738 "Over-expression of miR-30c or miR-181a decreased expression of p53, p21, ANP, cardiomyocyte cell size, and apoptosis in HG-treated cardiomyocytes." -genetics_overexpression_suppress hsa-mir-375 Colorectal Carcinoma 27222350 "miR-375 inhibited proliferation, invasion and migration in DLD1 and HCT8 cells." -genetics_overexpression_suppress hsa-mir-224 Osteosarcoma 27222381 "overexpression of miR-224 suppressed osteosarcoma cell proliferation, migration and invasion" -genetics_overexpression_suppress hsa-mir-214 Kidney Neoplasms 27226530 miR-214 significantly blocked IGF-1R-forced renal cancer cell proliferation -genetics_overexpression_suppress hsa-mir-137 Melanoma 27233613 Overexpression of miR-137 decreased cell proliferation and colony formation in vitro. -genetics_overexpression_suppress hsa-mir-126 "Carcinoma, Lung, Non-Small-Cell" 27236384 "Upregulation of miR-126 resulted in the decrease of the proliferation, migration, and invasive abilities of A549 cells" -genetics_overexpression_suppress hsa-mir-208b Myocardial Infarction 27236543 Overexpressing miR-208b improved myocardial functions -genetics_overexpression_suppress hsa-mir-134 "Carcinoma, Lung, Non-Small-Cell" 27241841 miR-134 suppressed tumour growth of A549 xenograft in nude mice. -genetics_overexpression_suppress hsa-mir-17 Mesothelioma 27245839 Transfection of MPM cells with a miR-17-5p mimic or KCNMA1-specific siRNAs reduced mRNA expression of KCa1.1 and inhibited MPM cell migration. -genetics_overexpression_suppress hsa-mir-450 Lung Neoplasms 27246609 transfection with lentivirus carrying miRâ€?50 upregulated miRâ€?50 expression and significantly attenuated lung cancer cell proliferation and invasion -genetics_overexpression_suppress hsa-mir-1 "Squamous Cell Carcinoma, Esophageal" 27247259 miRâ€? suppressed ESCC cell proliferation and increased apoptosis -genetics_overexpression_suppress hsa-mir-124 "Carcinoma, Lung" 27251409 overexpression of miR-124 in A549 cells suppressed cell migration and invasion activity -genetics_overexpression_suppress hsa-mir-218 "Cardiomyopathy, Hypertrophic" 27258257 Overexpression of miR-218 is sufficient to reduce hypertrophy -genetics_overexpression_suppress hsa-mir-497 Ischemia-Reperfusion Injury 27261611 miR-497 could inhibit inflammation and apoptosis of spinal cord IR through its targets -genetics_overexpression_suppress hsa-mir-744 Cervical Neoplasms 27261616 "up-regulation of miR-744 and down-regulation of Bcl-2 could stimulate Caspase-3 expression, promoting apoptosis of cervical cancer cells." -genetics_overexpression_suppress hsa-mir-663a "Carcinoma, Hepatocellular" 27261623 "miR-663a distinctly inhibited cell proliferation, migration and invasion." -genetics_overexpression_suppress hsa-mir-411 Breast Neoplasms 27264952 Ectopic expression of miR-411-5p suppressed the breast cancer cell proliferation -genetics_overexpression_suppress hsa-mir-26a Osteosarcoma 27270422 miR-26a overexpression inhibits the tumor cell growth both in vitro and in vivo. -genetics_overexpression_suppress hsa-mir-106b Atherosclerosis 27270534 Overexpression of miR-106b-5p with miR-106b-5p mimic inhibited PTEN expression and TNF-α-induced apoptosis in HUVEC. -genetics_overexpression_suppress hsa-mir-29b Liver Cirrhosis 27273381 miR-29b overexpression inhibited proliferation of LX-2 cells 24 h after transfection. -genetics_overexpression_suppress hsa-mir-320 "Carcinoma, Lung, Non-Small-Cell" 27277534 "miRâ€?20 inhibited cell growth, migration and invasion in NSCLC cells." -genetics_overexpression_suppress hsa-mir-375 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 27279635 "Overexpression of miR-375 led to a decreased protein level of Krüppel-like factor 4 (KLF4) and marked suppression of the proliferation and invasion, and induced apoptosis of LSCC cell line" -genetics_overexpression_suppress hsa-mir-24 "Carcinoma, Endometrial" 27279639 Up-regulation of miR-24 inhibited the cell proliferation -genetics_overexpression_suppress hsa-mir-205 Colon Neoplasms 27283988 miR-205 decreases cell proliferation and decreases migratory and invasive potential of colon cancer cells -genetics_overexpression_suppress hsa-mir-486 Colorectal Carcinoma 27284245 overexpression of miR-486-5p inhibited the tumor growth and lymphangiogenesis in nude mice -genetics_overexpression_suppress hsa-mir-210 Intervertebral Disc Degeneration 27284319 downregulation of miR-210 may promote Fas-mediated apoptosis in human IDD by regulating the expression of HOXA9. -genetics_overexpression_suppress hsa-mir-214 Ischemia-Reperfusion Injury 27288437 Overexpression of the two miRs in cardiomyocytes mimics the effects of carvedilol -genetics_overexpression_suppress hsa-mir-145 Liver Fibrosis 27289031 over-expression of miR-145 inhibited TGF-β1-induced the activation and proliferation of HSC-T6 cells in vitro. -genetics_overexpression_suppress hsa-mir-210 Colorectal Carcinoma 27293381 miR-210 mediated the induction of apoptosis -genetics_overexpression_suppress hsa-mir-153 Glioma 27295037 "Exogenous overexpression of miR-153 downregulated Rictor (mRNA and protein) and decreased p-Akt Ser473 in U87MG cells, leading to significant growth inhibition and apoptosis activation." -genetics_overexpression_suppress hsa-let-7 Neoplasms [unspecific] 27295554 genetic rescue of Let-7 miRNA activity in Dicer1-deficient TAMs partly restored their M2-like phenotype and decreased tumour-infiltrating CTLs. -genetics_overexpression_suppress hsa-mir-10b Cervical Neoplasms 27296950 overexpression of miR-10b in cervical cancer cells could inhibit the cell proliferation and invasion -genetics_overexpression_suppress hsa-mir-34b "Leukemia, Myeloid, Acute" 27296951 the miR-34b mimicked transfection-mediated restoration of miR-34b inhibited cell viability and promoted cell apoptosis of HL-60 and OCI-AML3 cell lines. -genetics_overexpression_suppress hsa-mir-149 "Carcinoma, Hepatocellular" 27300349 Overexpression of miR-149 or inhibition of PARP-2 expression could inhibit tumor growth but was more effective in sensitizing chemotherapy and radiotherapy in xenograft HCC animal models -genetics_overexpression_suppress hsa-mir-196b Lung Neoplasms 27302168 miR-196b reexpression also significantly reduced the growth of tumor xenografts. -genetics_overexpression_suppress hsa-mir-34 Pulmonary Hypertension 27302634 "miR-34a overexpression down-regulated platelet-derived growth factor receptor alpha (PDGFRA) expression, which is a key factor in PAH development." -genetics_overexpression_suppress hsa-mir-497 Breast Neoplasms 27303812 "Enforced miR-497 expression, accompanied with SMAD7 reduction, suppressed MDA-MB-231 and MCF-7 breast cancer cell growth" -genetics_overexpression_suppress hsa-mir-26b Bladder Neoplasms 27310702 Restoration of these miRNAs inhibited cell migration and invasion in BC. -genetics_overexpression_suppress hsa-mir-674 Liver Injury 27313091 miR-674-5p might be a negative regulator in 5-LO mediated autoimmune liver injury -genetics_overexpression_suppress hsa-mir-20a "Carcinoma, Hepatocellular" 27313460 growth of HepG2 cells in the miR-20a mimics group was significantly inhibited -genetics_overexpression_suppress hsa-mir-27a "Carcinoma, Renal Cell" 27313769 upregulated miR-27a attenuated RCC tumor growth in the tumor xenograft animal model -genetics_overexpression_suppress hsa-mir-494 Ovarian Neoplasms 27313773 Overexpression of miR-494 inhibited ovarian cancer cell proliferation by inducing apoptosis. -genetics_overexpression_suppress hsa-mir-218 "Carcinoma, Renal Cell" 27314976 cell proliferation was suppressed in miRâ€?18 mimic‑transfected RCC cells compared with control cells -genetics_overexpression_suppress hsa-mir-23a Osteoarthritis 27318087 miR-23a-3p overexpression suppresses type II collagen and aggrecan expression -genetics_overexpression_suppress hsa-mir-206 "Carcinoma, Breast, Triple Negative" 27318091 The miR-206 mimics inhibited TNBC breast cell invasion and angiogenesis. -genetics_overexpression_suppress hsa-let-7 Endometriosis 27320036 increased let-7f expression effectively reduced the migration of endometrial cells. -genetics_overexpression_suppress hsa-let-7f Endometriosis 27320036 increased let-7f expression effectively reduced the migration of endometrial cells. -genetics_overexpression_suppress hsa-mir-137 Glioblastoma 27328425 "overexpression of miR-137 in GBM cells also inhibited cell proliferation, migration, and invasion." -genetics_overexpression_suppress hsa-mir-148b Breast Neoplasms 27328731 "Depleting miR-214 or elevating miR-148b blocked the dissemination of melanoma or breast cancer cells, an effect that could be accentuated by dual alteration." -genetics_overexpression_suppress hsa-mir-148b Melanoma 27328731 "Depleting miR-214 or elevating miR-148b blocked the dissemination of melanoma or breast cancer cells, an effect that could be accentuated by dual alteration." -genetics_overexpression_suppress hsa-mir-30b "Carcinoma, Hepatocellular" 27333771 Gain- and loss-of-function studies revealed that miR-30b could dramatically inhibit in vitro HCC cell migration and invasion. -genetics_overexpression_suppress hsa-mir-141 "Carcinoma, Renal Cell, Clear-Cell" 27336447 a tumor suppressive effect of miR-141-3p and miR-145-5p by decreasing migration and invasion of RCC cells could be shown. -genetics_overexpression_suppress hsa-mir-145 "Carcinoma, Renal Cell, Clear-Cell" 27336447 a tumor suppressive effect of miR-141-3p and miR-145-5p by decreasing migration and invasion of RCC cells could be shown. -genetics_overexpression_suppress hsa-mir-18a "Carcinoma, Breast, Triple Negative" 27338042 Enforced miR-18a overexpression directly led to increased autophagy in MDA-MB-231 cells -genetics_overexpression_suppress hsa-mir-126 Age-Related Macular Degeneration 27338342 overexpression effects of miR-126 were also proven on human microvascular endothelial cells -genetics_overexpression_suppress hsa-mir-156a "Carcinoma, Nasopharyngeal" 27341697 synthetic miR156a mimic inhibited the EMT of NPC cells in vitro. -genetics_overexpression_suppress hsa-mir-376c Cervical Neoplasms 27345009 "Upregulation of miR-376c impaired cell proliferation, blocked G1/S checkpoint of cell cycle and suppressed cell invasion in vitro." -genetics_overexpression_suppress hsa-mir-195 Colon Neoplasms 27347317 "Overexpression of miR-195-5p inhibited cellular growth, suppressed cellular migration and invasion, and led to cell cycle arrest at G1 phase in vitro." -genetics_overexpression_suppress hsa-mir-132 Chronic Pain 27349406 Spinal administration of miR-132-3p antagonists via intrathecal (i.t.) catheters dose dependently reversed mechanical allodyina (p<0.001) and eliminated pain behavior -genetics_overexpression_suppress hsa-mir-24 Cerebral Ischemia 27349868 miR-24 overexpression or silencing of neurocan shows an antihypoxic effect in SH-SY5Y cells. -genetics_overexpression_suppress hsa-mir-24 Lacrimal Adenoid Cystic Carcinoma 27351203 overexpression of miR-24-3p decreased its malignant phenotype. -genetics_overexpression_suppress hsa-mir-449a Lung Fibrosis 27351886 miR-449a significantly reduced both the distribution and severity of lung lesions induced by silica. -genetics_overexpression_suppress hsa-mir-410 Systemic Lupus Erythematosus 27351906 overexpression of miR-410 significantly reduced the expression levels of IL-10. -genetics_overexpression_suppress hsa-mir-548an Pancreatic Neoplasms 27353169 overexpression of miR-548an significantly inhibited the proliferation and invasion of pancreatic cancer cell -genetics_overexpression_suppress hsa-mir-140 Gastric Neoplasms 27353653 miR-140 overexpression inhibited HGC-27 cell viability and colony formation and resulted in G0/G1 arrest. -genetics_overexpression_suppress hsa-mir-139 Bladder Neoplasms 27355528 Gain-of-function studies showed that miR-139-5p and miR-139-3p significantly inhibited cell migration and invasion by BC cells. -genetics_overexpression_suppress hsa-mir-335 Bladder Neoplasms 27356628 Overexpression of miRâ€?35 in T24 cells inhibited cell proliferation and induced apoptosis -genetics_overexpression_suppress hsa-mir-200b "Carcinoma, Lung, Non-Small-Cell" 27356635 Overexpression of miRâ€?00b significantly inhibited NSCLC cell migration and invasion. -genetics_overexpression_suppress hsa-mir-143 "Squamous Cell Carcinoma, Esophageal" 27358073 Ectopic expression of miR-143-3p also reduced the metastatic potential of cells by selectively regulating epithelial-mesenchymal transition regulatory proteins. -genetics_overexpression_suppress hsa-mir-330 Cutaneous Melanoma 27363653 Enforced expression of miR-330-5p inhibits malignant CMM cells proliferation and migration and led to downregulation of the TYR and PDIA3 protein. -genetics_overexpression_suppress hsa-mir-145 "Carcinoma, Breast, Triple Negative" 27364572 Upregulating miR-145 in HCC1937 cells dramatically suppressed cell proliferation and induced G1-phase arrest -genetics_overexpression_suppress hsa-mir-124 "Carcinoma, Lung, Non-Small-Cell" 27376157 "Overexpression of miR-124 significantly suppresses tumor cell proliferation, colony formation, migration, and induction of apoptosis in H322 and A549 cells." -genetics_overexpression_suppress hsa-mir-26a "Fatty Liver, Non-Alcoholic" 27377869 LV-26a-infected mice were protected from glucose dysmetabolism and showed markedly decreased total liver weight -genetics_overexpression_suppress hsa-mir-125b Ovarian Neoplasms 27383536 Ectopic expression of miR-125b in EOC cells significantly inhibited tumor invasion. -genetics_overexpression_suppress hsa-mir-106a Osteosarcoma 27383537 "Downregulation of miR-106a-5p was found in OS tissues, and upregulation of miR-106a-5p can inhibit the proliferation, migration, and invasion by targeting HMGA2 in OS cells." -genetics_overexpression_suppress hsa-mir-210 Acute Ischemic Stroke 27390218 Lentivirus-mediated miR-210 overexpression enhanced the microvessel density and the number of neural progenitor cells in the ischemic mouse brain (P < 0.05) and improved neurobehavioral outcomes in the ischemic mouse (P < 0.05). -genetics_overexpression_suppress hsa-mir-7 "Carcinoma, Hepatocellular" 27391479 Overexpression of miR-7 inhibited the HCC cell proliferation and invasion. Overexpression of miR-7 could suppress the direct target gene CCNE1 and PIK3CD expression. -genetics_overexpression_suppress hsa-mir-185 Idiopathic Pulmonary Fibrosis 27392970 "Furthermore, mimics of miR-185 and miR-186 blocked transforming growth factor-β-induced collagen V overexpression and alleviated transforming growth factor-β-induced epithelial-mesenchymal transition in A549 cells and HCC827 cells." -genetics_overexpression_suppress hsa-mir-186 Idiopathic Pulmonary Fibrosis 27392970 "Our findings suggest that attenuated expression of miR-185 and miR-186 may be responsible for collagen V overexpression during idiopathic pulmonary fibrosis, and these miRNAs may serve as pathogenesis-related biomarkers and treatment targets." -genetics_overexpression_suppress hsa-mir-449a "Carcinoma, Hepatocellular" 27398144 "Ectopic expression of miR-449a suppressed HCC cell proliferation, colony formation, migration and invasion." -genetics_overexpression_suppress hsa-mir-146a Liver Cirrhosis 27399683 "Overexpression of miR-146a-5p inhibited LPS induced pro-inflammatory cytokines secretion through down-regulating the expression levels of TLR-4, IL-1 receptor-associated kinase 1 (IRAK1), TNF receptor associated factor-6 (TRAF6) and phosphorylation of nuclear factor-kappa B (NF-κB)." -genetics_overexpression_suppress hsa-mir-200 "Carcinoma, Breast, Triple Negative" 27402080 "miR-9 and miR-200 promoted and inhibited, respectively, the formation of vascular-like structures in vitro" -genetics_overexpression_suppress hsa-mir-149 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 27403438 In vitro studies revealed that the exogenous expression of miRNA-149 inhibits the proliferation of human Hep-2 cells and induces cell apoptosis. -genetics_overexpression_suppress hsa-mir-218 Chronic Obstructive Pulmonary Disease 27409149 Perturbation experiments with a miR-218-5p mimic or inhibitor demonstrated a protective role of miR-218-5p in cigarette smoke-induced inflammation and COPD. -genetics_overexpression_suppress hsa-mir-133a Heart Diseases [unspecific] 27411382 "Our results revealed that miR-133a mimic treatment improved the contractility of the diabetic rat's heart concomitant with upregulation of TH, cardiac NE, β-AR, and downregulation of TAT and plasma levels of NE." -genetics_overexpression_suppress hsa-mir-141 "Carcinoma, Hepatocellular" 27412940 "Over-expression of miR-141 inhibits the proliferation, invasion and migration of hepatocellular carcinoma MHCC-97H cells" -genetics_overexpression_suppress hsa-mir-149 Colorectal Carcinoma 27415661 "Re-expression of miR-149 could enhance the 5-FU sensitivity of 5-FU-resistant CRC cells by increasing 5-FU-inducing apoptosis, while downregulation of miR-149 could decrease the 5-FU sensitivity of parental CRC cells by decreasing 5-FU-inducing apoptosis" -genetics_overexpression_suppress hsa-mir-18a "Carcinoma, Hepatocellular" 27421245 "We transfected HepG2.2.15 with miR-18a mimics and CTGF siRNA, finding that upregulated miR-18a and downregulated CTGF suppress the viability and cause cell cycle arrest." -genetics_overexpression_suppress hsa-mir-34a Leukemia 27424989 "Induced expression of miR-34a in TIM3 positive leukemia stem cells (LSC), inhibits the clonogenic expansion, tumor progression and metastasis of leukemia." -genetics_overexpression_suppress hsa-mir-320b "Carcinoma, Nasopharyngeal" 27428374 "Further studies showed that overexpression of miR-320b suppressed NPC cell proliferation and enhanced mitochondrial fragmentation and apoptosis both in vitro and in vivo, while silencing of miR-320b promoted tumor growth and suppressed apoptosis." -genetics_overexpression_suppress hsa-mir-497 Invasive Bladder Transitional Cell Carcinoma 27430325 "We also found that overexpression of miR-497 inhibited the proliferation, migration and invasion of bladder cancer cells by downregulating E2F3 (an miR-497 target gene) mRNA and protein and that siRNA against E2F3 inhibited cell proliferation, migration and invasion, which was similar to the effect of miR-497 overexpression in the BTCC cells." -genetics_overexpression_suppress hsa-mir-338 Lung Neoplasms 27431198 "Regaining the expression of miR-338 in lung cancer cell lines significantly impaired cellular adhesion, migration, invasion and lung tumor formation in nude mice." -genetics_overexpression_suppress hsa-mir-184 "Carcinoma, Renal Cell" 27431728 "Overexpression of pre-miR-184 changed the metabolic and proliferation features of ccRCC cells by reducing cell glucose consumption, lactate production and cell proliferation." -genetics_overexpression_suppress hsa-mir-183 "Carcinoma, Nasopharyngeal" 27431799 "Using transient or stable transfection, we showed that ectopic expression of miR-96 and miR-183 suppressed cell growth and tumor sphere formation in NPC." -genetics_overexpression_suppress hsa-mir-96 "Carcinoma, Nasopharyngeal" 27431799 "Using transient or stable transfection, we showed that ectopic expression of miR-96 and miR-183 suppressed cell growth and tumor sphere formation in NPC." -genetics_overexpression_suppress hsa-mir-30a Prostate Neoplasms 27431942 "miRâ€?0a overexpression resulted in a significant suppression of cell growth in vitro, and reduced tumorigenicity in vivo." -genetics_overexpression_suppress hsa-mir-200c Lung Neoplasms 27432063 "Over expression of miR-200c could significantly inhibit cell proliferation, induce G0/G1 cell cycle arrest and induce cell apoptosis." -genetics_overexpression_suppress hsa-mir-27a "Squamous Cell Carcinoma, Oral" 27432214 "Intriguingly, increased expression of miR-27a-3p could significantly decrease the expression level of YAP1 as well as several epithelial to mesenchymal transition (EMT)-related molecules in OSCC cell lines, including Twist and Snail." -genetics_overexpression_suppress hsa-mir-199a Testicular Neoplasms 27432288 it was determined that overexpression of miRâ€?99aâ€?p in Nteraâ€? cells caused suppression of cell growth and migration. -genetics_overexpression_suppress hsa-mir-541 "Carcinoma, Lung, Non-Small-Cell" 27448300 We found that expression of miR-541-3p was decreased obviously in NSCLC tissues and plasma. Down-regulation of miR-541-3p was associated with TNM stage and postoperative survival. -genetics_overexpression_suppress hsa-mir-26a Prostate Neoplasms 27449037 It was confirmed that miR-26a-5p was markedly downregulated in PC tissues compared with normal controls whose reduced expression was significantly associated with metastasis and poor overall prognosis and found that miR-26a-5p was able to prevent proliferation and motility of PC cells in vitro. -genetics_overexpression_suppress hsa-mir-613 Breast Neoplasms 27449609 "miR-613 mimics significantly inhibited the migration and invasion of breast cancer cells, whereas miR-613 inhibitors significantly increased cell migration and invasion." -genetics_overexpression_suppress hsa-mir-455 Gastric Neoplasms 27451075 "re-expression of miR-455-5p could inhibit human GC cell proliferation and invasion, overexpression of miR-455-5p could also promote GC cell apoptosis." -genetics_overexpression_suppress hsa-mir-338 "Carcinoma, Lung, Non-Small-Cell" 27453416 Forced expression of miR-338-3p in A549 cells led to the suppression of migration/invasion capacity and inhibition of epithelial markers. -genetics_overexpression_suppress hsa-mir-34a "Carcinoma, Cervical" 27456356 "While forced expression of miR-34a in CaCx and CRC cells inhibited HMGB1 mRNA and protein levels, proliferation, migration and invasion, inhibition of endogenous miR-34a enhanced these tumourigenic properties." -genetics_overexpression_suppress hsa-mir-34a Colorectal Carcinoma 27456356 "While forced expression of miR-34a in CaCx and CRC cells inhibited HMGB1 mRNA and protein levels, proliferation, migration and invasion, inhibition of endogenous miR-34a enhanced these tumourigenic properties." -genetics_overexpression_suppress hsa-mir-497 Breast Neoplasms 27456360 "Further, overexpression of miR-497 not only inhibited ERRα expression but also reduced MIF level and MMP9 activity, which led to significant decreases in cell proliferation, migration, and invasion of ERα negative breast cancer." -genetics_overexpression_suppress hsa-mir-15a "Carcinoma, Nasopharyngeal" 27458095 "As a result, miR-15a overexpression significantly reduced cell proliferation (pâ€?â€?.01 or pâ€?â€?.001) and induced cell apoptosis (pâ€?â€?.001), while miR-15a suppression got the opposite result for cell proliferation and apoptosis." -genetics_overexpression_suppress hsa-mir-451 "Carcinoma, Hepatocellular" 27461244 "In this study, overexpression of miR-451 clearly attenuated the promoting effects of HCC cells on cell proliferation, migration and tube formation of human umbilical vein endothelial cells (HUVECs)." -genetics_overexpression_suppress hsa-mir-1207 "Carcinoma, Hepatocellular" 27461404 Overexpression of miR-1207-5p significantly suppressed the cell growth and invasion of HCC cells. -genetics_overexpression_suppress hsa-mir-34c Prostate Neoplasms 27461446 "In this study, we identified that miR-34C was under-expressed in the purified CD133+ PCSCs and enforced introduction of miR-34C attenuated the stemness of CD133+ PCSCs." -genetics_overexpression_suppress hsa-mir-520a Lymphoma 27461820 "Our data indicated that the mimics of miRâ€?20a inhibited growth, proliferation of Raji cells and promoted its apoptosis, which was related to downregulation of AKT1, NF‑κB and ER stress response mediated by PERK/eIF2α pathway." -genetics_overexpression_suppress hsa-mir-520a "Lymphoma, Burkitt" 27461820 "Our data indicated that the mimics of miRâ€?20a inhibited growth, proliferation of Raji cells and promoted its apoptosis, which was related to downregulation of AKT1, NF‑κB and ER stress response mediated by PERK/eIF2α pathway." -genetics_overexpression_suppress hsa-mir-520a "Lymphoma, Hodgkin" 27461820 "Our data indicated that the mimics of miRâ€?20a inhibited growth, proliferation of Raji cells and promoted its apoptosis, which was related to downregulation of AKT1, NF‑κB and ER stress response mediated by PERK/eIF2α pathway." -genetics_overexpression_suppress hsa-mir-520a "Lymphoma, Non-Hodgkin" 27461820 "Our data indicated that the mimics of miRâ€?20a inhibited growth, proliferation of Raji cells and promoted its apoptosis, which was related to downregulation of AKT1, NF‑κB and ER stress response mediated by PERK/eIF2α pathway." -genetics_overexpression_suppress hsa-mir-132 "Carcinoma, Hepatocellular" 27467251 The tumor-suppressive role of miR-132 in HCC has been further confirmed by in vitro experiments. -genetics_overexpression_suppress hsa-mir-203 Glioblastoma 27467502 Conversely reconstitution of miR-203 expression induced apoptosis and inhibited migratory property of glioma cells. -genetics_overexpression_suppress hsa-mir-26a Osteosarcoma 27468358 "Using in vitro and in vivo assays, we confirmed that miR-26a could inhibit the abilities of in vitro proliferation and suppress in vivo tumor growth in mouse model." -genetics_overexpression_suppress hsa-mir-205 "Carcinoma, Breast" 27468619 Knock-up of miR-205 expression by transfection with its mimics promoted MDA-MB-468 cells apoptosis (P=0.006 1). -genetics_overexpression_suppress hsa-mir-137 "Carcinoma, Gastric" 27468717 "Over expression of miR-137 could inhibit the cell migration, proliferation, and promote cell cycle arrest in G0/G1 stage in BGC-823 and SGC-7901 cell lines." -genetics_overexpression_suppress hsa-mir-182 "Carcinoma, Renal Cell, Clear-Cell" 27468875 "Compared to the control group, cell viability, colony-forming ability, and numbers of migrated and invaded cells were significantly decreased by transfection with miR-182 mimic but were markedly increased by miR-182 inhibitor (all P < 0.05)." -genetics_overexpression_suppress hsa-mir-148a "Carcinoma, Ovarian" 27470550 "Moreover, cell experiments confirmed that miR-148a could inhibit proliferation, migration and invasion of ovarian cancer cells." -genetics_overexpression_suppress hsa-mir-122 Cholangiocarcinoma 27472451 "MiR-122 overexpression reduced cell invasion and migration ability, and inhibited cell apoptosis and p53 expression. Inhibiting miR-122 caused the opposite results." -genetics_overexpression_suppress hsa-mir-451 Glioma 27476171 "By targeting CAB 39, miRNA-451 likely triggers the LKB1/AMPK/PI3K/AKT pathway, which regulates GLUT1, to inhibit the glucose metabolism of, reduce the energy supply to, and inhibit the proliferation and invasion of glioma cells." -genetics_overexpression_suppress hsa-mir-29b Wound Healing 27477081 "Importantly, local delivery of miR-29b lentiviral particles inhibited HSP47 expression and collagen biosynthesis as well as suppressed angiogenesis, thus reducing scar formation in an excisional wound splinting model." -genetics_overexpression_suppress hsa-mir-194 "Squamous Cell Carcinoma, Esophageal" 27480251 miR-194 was found to inhibit proliferation and invasion and promote apoptosis of esophageal squamous cell carcinoma cells. -genetics_overexpression_suppress hsa-mir-203 Glioblastoma 27484906 MicroRNA-203 transfected GBM-SCs had reduced capacity for self-renewal in the cell sphere assay and increased expression of glial and neuronal differentiation markers. -genetics_overexpression_suppress hsa-mir-26a Vascular Hypertrophy 27485101 "Taken together, the present study suggested an anti‑hypertrophic role of miRâ€?6a in cardiac hypertrophy, possibly via inhibition of GATA4." -genetics_overexpression_suppress hsa-mir-101 "Carcinoma, Bladder" 27485165 "In addition, plasmid‑mediated overexpression of miRâ€?01 and small hairpin RNA‑mediated inhibition of c‑FOS significantly inhibited the proliferation and invasive capacity of T24 cells." -genetics_overexpression_suppress hsa-mir-610 Glioma 27485527 "Furthermore, the present study revealed that miRâ€?10 inhibited cell growth, migration and invasion in glioma cells." -genetics_overexpression_suppress hsa-mir-329 Osteosarcoma 27487475 "MiR-329 is able to inhibit osteosarcoma cell proliferation, promote apoptosis, and induce G0/G1 cell cycle arrest." -genetics_overexpression_suppress hsa-mir-29a "Carcinoma, Lung" 27488440 Restoration of miR-29a suppressed cancer cell aggressiveness and fibroblast migration. -genetics_overexpression_suppress hsa-mir-29a Idiopathic Pulmonary Fibrosis 27488440 Restoration of miR-29a suppressed cancer cell aggressiveness and fibroblast migration. -genetics_overexpression_suppress hsa-mir-29b Granular Corneal Dystrophy 27490049 Overexpression of miR-29b decreased ECM protein production in human corneal endothelial cells. -genetics_overexpression_suppress hsa-mir-1299 "Carcinoma, Hepatocellular" 27490780 "miR-1299 overexpression inhibited cell proliferation and arrested cell cycle in G0/G1 phase analyzed by MTT assay, soft agar assay, BrdU cell proliferation assay and cell cycle assay, while miR-1299 knockdown promoted cell proliferation and accelerated G1/S transition." -genetics_overexpression_suppress hsa-mir-15a Melanoma 27492455 miR-15a displayed inhibitory effects on proliferation and invasiveness of several malignant melanoma cell lines. -genetics_overexpression_suppress hsa-mir-137 "Carcinoma, Hepatocellular" 27492460 "Overexpression of miR-137 via adenoviral vector inhibited the proliferation and anchorage-independent growth of HCC cells, HepG2 and MHCC-97H." -genetics_overexpression_suppress hsa-mir-143 Leukemia 27492780 miRNA143 transfection inhibited K562 cell growth and induced its apoptosis. -genetics_overexpression_suppress hsa-mir-3178 "Carcinoma, Gastric" 27493095 "The condition medium from miR-3178 mimic transfected GES-1 cells could inhibit proliferation and induce apoptosis of inflammation-related gastric cancer cells SGC7901 and MGC803 by decreasing the production of inflammatory cytokines TNF-α and IL-6, which were secreted by GES-1 cells." -genetics_overexpression_suppress hsa-mir-187 "Carcinoma, Lung, Non-Small-Cell" 27495872 Overexpression of miR-187-5p inhibited the growth and metastasis of NSCLC cells. -genetics_overexpression_suppress hsa-mir-155 Allergy 27497617 miR-155 overexpression significantly suppressed IL-13-induced secretion of CCL11 and CCL26. -genetics_overexpression_suppress hsa-mir-509 "Carcinoma, Lung" 27498003 "In addition, over-expression of miR-509-3-5p markedly blocked A549 cell proliferation and sensitized the cells to CIS and ADR treatment." -genetics_overexpression_suppress hsa-let-7a "Carcinoma, Colon" 27498032 Further studies demonstrated that over-expressed let-7a could remarkably inhibit HCT-116 and SW620 cell growth and metastasis by directly down-regulating Rhotekin (RTKN). -genetics_overexpression_suppress hsa-mir-140 Glioma 27498787 "Restoration of miR-140 obviously suppressed glioma cell proliferation, migration and invasion." -genetics_overexpression_suppress hsa-mir-205 "Carcinoma, Renal Cell" 27498834 "It was revealed that miRâ€?05 promoted the apoptosis of RCC cells and suppressed their proliferation, metastasis and invasion compared with the negative control." -genetics_overexpression_suppress hsa-mir-124 Retinoblastoma 27498908 "The ectopic expression of miR-124 in the RB cell lines (Y79 and SO-RB50) suppresses cell proliferation, migration and invasion, induced cell apoptosis in vitro." -genetics_overexpression_suppress hsa-mir-186 "Carcinoma, Lung, Non-Small-Cell" 27498924 "Furthermore, overexpression of miR-186 suppressed lung cancer cell proliferation, migration and invasion, and induced cell apoptosis." -genetics_overexpression_suppress hsa-mir-107 "Carcinoma, Lung" 27498977 "Function assays showed that overexpression of miR-107 suppressed cell proliferation, migration and invasion in A549 cells in vitro, and inhibited NSCLC tumor growth in vivo." -genetics_overexpression_suppress hsa-mir-17 "Carcinoma, Ovarian" 27499367 "Forced expression of miR-17 led to markedly diminished adhesion and invasion of ovarian cancer cells in vitro, and notably reduced metastatic nodules inside the peritoneal cavity in in vivo SKOV3 xenografts model." -genetics_overexpression_suppress hsa-mir-370 "Carcinoma, Gastric" 27499479 Upregulation of microRNA-370 promotes cell apoptosis and inhibits proliferation by targeting PTEN in human gastric cancer. -genetics_overexpression_suppress hsa-mir-622 "Squamous Cell Carcinoma, Esophageal" 27501502 "Up-regulation of miR-622 could significantly reduce ESCC cell proliferation, enhance cell apoptosis, and impair cell invasion and migration in vitro, while down-regulation of miR-622 showed opposite effects." -genetics_overexpression_suppress hsa-mir-223 Ischemia-Reperfusion Injury 27502281 Precursor miR-223 (pre-miR-223) transgenic mouse hearts exhibited better recovery of contractile performance over reperfusion period and lesser degree of myocardial necrosis than wild type hearts upon ex vivo and in vivo myocardial ischemia. -genetics_overexpression_suppress hsa-mir-148b "Carcinoma, Cervical" 27505047 "miR-148b mimics significantly decreased the cell proliferation ability and invasion ability, and statistically induced apoptosis." -genetics_overexpression_suppress hsa-mir-139 "Carcinoma, Cervical" 27505862 "Overexpression of miR-139-3p significantly suppressed HeLa cell proliferation, migration and invasion and induced cell apoptosis." -genetics_overexpression_suppress hsa-mir-490 "Carcinoma, Breast, Triple Negative" 27506313 Gain-of-function studies revealed that miR-490-3p-3p overexpression inhibited cell growth and invasion in both MDA-MB-231 and MDA-MB-436 TNBC cells and impaired tumorigenesis of MDA-MB-231 cells in nude mice. -genetics_overexpression_suppress hsa-mir-122 Bladder Neoplasms 27508026 "Furthermore, miR-122 over-expression decreases bladder cancer cell migration, invasion, colony formation in vitro and slow bladder cancer growth and angiogenesis in vivo." -genetics_overexpression_suppress hsa-mir-145 Breast Neoplasms 27508031 Wound healing assay and transwell migration assay showed that ectopic expression of miR-145 significantly inhibited breast cancer cell migration. -genetics_overexpression_suppress hsa-mir-338 Ovarian Neoplasms 27508048 "Restoration of miR-338-3p expression in ovarian cancer cells could inhibit cell proliferation, lactate production and lactate production of ovarian cancer cells." -genetics_overexpression_suppress hsa-mir-20a "Squamous Cell Carcinoma, Esophageal" 27508097 "Together, our findings demonstrate that miR-17/20a suppresses cell migration and invasion of ESCC by modulating TGF-β/ITGB6 pathway." -genetics_overexpression_suppress hsa-mir-497 "Carcinoma, Ovarian" 27513319 Overexpression of microRNA-497 suppresses cell proliferation and induces apoptosis through targeting paired box 2 in human ovarian cancer. -genetics_overexpression_suppress hsa-mir-221 Lung Fibrosis 27513632 miRâ€?21 targets HMGA2 to inhibit bleomycin‑induced pulmonary fibrosis by regulating TGF‑Î?/Smad3-induced EMT. -genetics_overexpression_suppress hsa-mir-106a "Carcinoma, Bladder" 27513725 Overexpression of mir-106a suppressed the proliferation of bladder cancer cell in EJ. -genetics_overexpression_suppress hsa-mir-34a "Carcinoma, Gastric" 27513895 Upregulation of miR-34a enhanced the DDP sensitivity of SGC7901/DDP cells to DDP through the inhibition of cell proliferation and induction of cell apoptosis. -genetics_overexpression_suppress hsa-mir-101 "Leukemia, Myeloid, Chronic" 27517565 These findings suggest that miR-101 acts as a tumor suppressor by downregulating Jak2 expression and sensitizing K562 cells to imatinib. -genetics_overexpression_suppress hsa-mir-181a Leukemia 27517749 "NP-mediated upregulation of miR-181a led to reduced proliferation, impaired colony formation and increased sensitivity to chemotherapy." -genetics_overexpression_suppress hsa-mir-26a "Carcinoma, Breast" 27517917 MiR-26a overexpression resulted in a reduction in cell viability that was partially recovered by inhibiting it. -genetics_overexpression_suppress hsa-mir-148a "Carcinoma, Gastric" 27518872 "Ectopic expression of miR-148a inhibited tumor cell proliferation and migration in vitro, and inhibited tumor formation in vivo." -genetics_overexpression_suppress hsa-let-7b Glioma 27520092 "upregulation of Let-7b, a member of the Let-7 microRNA family, inhibited proliferation, migration, and invasion in glioma cell lines." -genetics_overexpression_suppress hsa-mir-34a "Carcinoma, Breast" 27524218 MiR-34a expression was remarkably down-regulated in BC tissues and cell lines compared with normal tissues and cell lines. -genetics_overexpression_suppress hsa-mir-132 "Carcinoma, Prostate" 27527117 "Notably, overexpression of miR-132/212 could inhibit TGF-¦Â (transforming growth factor-¦Â)-induced EMT in Vcap and Lncap cells at both the mRNA and protein expression levels." -genetics_overexpression_suppress hsa-mir-132 Prostate Neoplasms 27527117 "Notably, overexpression of miR-132/212 could inhibit TGF-¦Â (transforming growth factor-¦Â)-induced EMT in Vcap and Lncap cells at both the mRNA and protein expression levels." -genetics_overexpression_suppress hsa-mir-212 "Carcinoma, Prostate" 27527117 "Notably, overexpression of miR-132/212 could inhibit TGF-¦Â (transforming growth factor-¦Â)-induced EMT in Vcap and Lncap cells at both the mRNA and protein expression levels." -genetics_overexpression_suppress hsa-mir-210 Ischemic Diseases [unspecific] 27530798 "Neonatal rats show down-regulated expression of miRNA-210 after HI, suggesting that miRNA-210 may be involved in the development and progression of hypoxic-ischemic brain edema in neonatal rats." -genetics_overexpression_suppress hsa-mir-15a Diabetes Mellitus 27531575 "miR-15a overexpression led to modulation toward nondiabetic levels, rather than complete inhibition of ASM and VEGF-A providing therapeutic effect without detrimental consequences of ASM and VEGF-A deficiencies" -genetics_overexpression_suppress hsa-mir-15a Diabetic Retinopathy 27531575 "Over-expression of miR-15a downregulated, and inhibition of miR-15a upregulated ASM and VEGF-A expression in retinal cells." -genetics_overexpression_suppress hsa-mir-1 Heart Diseases [unspecific] 27531746 We also found that microRNAs (miRNAs) 1 and 21 bind PLN strongly and relieve PLN inhibition of SERCA to a greater extent than a similar length random sequence RNA mixture. -genetics_overexpression_suppress hsa-mir-21 Heart Diseases [unspecific] 27531746 We also found that microRNAs (miRNAs) 1 and 21 bind PLN strongly and relieve PLN inhibition of SERCA to a greater extent than a similar length random sequence RNA mixture. -genetics_overexpression_suppress hsa-mir-613 Ischemia-Reperfusion Injury 27534371 miR-613 inhibits I/R-induced cardiomyocyte apoptosis by targeting PDCD10 by regulating the PI3K/AKT signaling pathway -genetics_overexpression_suppress hsa-mir-613 Myocardial Ischemic-Reperfusion Injury 27534371 miR-613 inhibits I/R-induced cardiomyocyte apoptosis by targeting PDCD10 by regulating the PI3K/AKT signaling pathway. -genetics_overexpression_suppress hsa-mir-17 Rheumatoid Arthritis 27534557 MicroRNA-17 Suppresses TNF-B Signaling by Interfering with TRAF2 and cIAP2 Association in Rheumatoid Arthritis Synovial Fibroblasts. -genetics_overexpression_suppress hsa-mir-200a "Cardiomyopathy, Ischemic" 27573160 Overexpression of miR-200a protects cardiomyocytes against hypoxia-induced apoptosis by modulating the kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 signaling axis. -genetics_overexpression_suppress hsa-mir-21 Ischemia-Reperfusion Injury 27593550 Overexpression of microRNA-21 protects spinal cords against transient ischemia. -genetics_overexpression_suppress hsa-mir-140 Osteosarcoma 27624383 Overexpression of miR-140 Inhibits Proliferation of Osteosarcoma Cells via Suppression of Histone Deacetylase 4. -genetics_overexpression_suppress hsa-mir-422a Osteosarcoma 27779704 "Overexpression of miR-422a inhibits cell proliferation and invasion, and enhances chemosensitivity in osteosarcoma cells." -genetics_overexpression_suppress hsa-mir-21 "Carcinoma, Hepatocellular" 27793160 Overexpression of microRNA-21 strengthens stem cell-like characteristics in a hepatocellular carcinoma cell line. -genetics_overexpression_suppress hsa-mir-126 Atherosclerosis 27827458 MicroRNA-126 overexpression rescues diabetes-induced impairment in efferocytosis of apoptotic cardiomyocytes. -genetics_overexpression_suppress hsa-mir-93 Glaucoma 27878244 MicroRNA?93 is overexpressed and induces apoptosis in glaucoma trabecular meshwork cells. -genetics_overexpression_suppress hsa-mir-365 "Carcinoma, Breast" 27906431 Overexpression of microRNA-365 inhibits breast cancer cell growth and chemo-resistance through GALNT4. -genetics_overexpression_suppress hsa-mir-210 "Carcinoma, Pancreatic" 27940128 microRNA-210 overexpression inhibits tumor growth and potentially reverses gemcitabine resistance in pancreatic cancer. -genetics_overexpression_suppress hsa-mir-34a "Carcinoma, Colon" 28035390 "overexpression of miR-34a may inhibit the proliferation, invasion and metastasis of HCT116 cells" -genetics_overexpression_suppress hsa-mir-1 Heart Failure 28063219 MicroRNA-1 overexpression blunts cardiomyocyte hypertrophy elicited by thyroid hormone. -genetics_overexpression_suppress hsa-mir-142 "Carcinoma, Hepatocellular" 28081734 MicroRNA-142-5p Overexpression Inhibits Cell Growth and Induces Apoptosis by Regulating FOXO in Hepatocellular Carcinoma Cells. -genetics_overexpression_suppress hsa-mir-27b "Carcinoma, Lung, Non-Small-Cell" 28081743 "Overexpression of MicroRNA-27b Inhibits Proliferation, Migration, and Invasion via Suppression of MET Expression." -genetics_overexpression_suppress hsa-mir-29a Glioblastoma 28212562 Overexpression of miR-29a reduces the oncogenic properties of glioblastoma stem cells by downregulating Quaking gene isoform 6. -genetics_overexpression_suppress hsa-mir-519d "Adenocarcinoma, Lung" 28351305 Overexpression of miR-519d in lung adenocarcinoma inhibits cell proliferation and invasion via the association of eIF4H. -genetics_overexpression_suppress hsa-mir-138 Coronary Artery Disease 28371277 Overexpression of microRNA-138 alleviates human coronary artery endothelial cell injury and inflammatory response by inhibiting the PI3K/Akt/eNOS pathway. -genetics_overexpression_suppress hsa-mir-24 "Lymphoma, Hodgkin" 28432871 miR-24-3p Is Overexpressed in Hodgkin Lymphoma and Protects Hodgkin and Reed-Sternberg Cells from Apoptosis. -genetics_overexpression_suppress hsa-mir-125b "Leukemia, Myeloid, Acute" 28478034 "Overexpression of microRNA-125b inhibits human acute myeloid leukemia cells invasion, proliferation and promotes cells apoptosis by targeting NF-¦ÊB signaling pathway." -genetics_overexpression_suppress hsa-mir-194 Adenovirus Infection 28618953 Overexpression of microRNA-194 suppresses the epithelial-mesenchymal transition in targeting stem cell transcription factor Sox3 in endometrial carcinoma stem cells. -genetics_overexpression_suppress hsa-mir-183 "Carcinoma, Nasopharyngeal" 28631568 MiR-183 overexpression inhibits tumorigenesis and enhances DDP-induced cytotoxicity by targeting MTA1 in nasopharyngeal carcinoma. -genetics_overexpression_suppress hsa-mir-211 Thyroid Neoplasms 28703321 "Overexpression miR-211-5p hinders the proliferation, migration, and invasion of thyroid tumor cells by downregulating SOX11." -genetics_overexpression_suppress hsa-mir-124 Cardiovascular Diseases [unspecific] 28849090 Overexpressed microRNA-506 and microRNA-124 alleviate H2O2-induced human cardiomyocyte dysfunction by targeting kr¨¹ppel-like factor 4/5. -genetics_overexpression_suppress hsa-mir-506 Cardiovascular Diseases [unspecific] 28849090 Overexpressed microRNA-506 and microRNA-124 alleviate H2O2-induced human cardiomyocyte dysfunction by targeting kr¨¹ppel-like factor 4/5. -genetics_overexpression_suppress hsa-mir-34a "Carcinoma, Cervical" 28893346 Overexpression of MicroRNA-34a-5p Inhibits Proliferation and Promotes Apoptosis of Human Cervical Cancer Cells by Downregulation of Bcl-2. -genetics_overexpression_suppress hsa-mir-19a Colorectal Carcinoma 29207158 Overexpression of miR-19a inhibits colorectal cancer angiogenesis by suppressing KRAS expression -genetics_overexpression_suppress hsa-mir-150 Ischemia-Reperfusion Injury 29328381 Overexpressing microRNA-150 attenuates hypoxia-induced human cardiomyocyte cell apoptosis by targeting glucose-regulated protein-94 -genetics_overexpression_suppress hsa-mir-204 Ischemia-Reperfusion Injury 29421577 overexpression of miR-204 has a protective effect against myocardial I/R injury -genetics_overexpression_suppress hsa-mir-145 Breast Neoplasms 29425746 miR-145 overexpression triggers alteration of the whole transcriptome and inhibits breast cancer development -genetics_overexpression_suppress hsa-mir-143 "Carcinoma, Lung, Non-Small-Cell" 29630116 "overexpression of miR-143 downregulated cell proliferation, promoted the apoptosis, and suppressed the phosphorylation of EGFR, AKT and ERK1/2; thus, miR-143 may play a role in treatment of NSCLC to enhance therapeutic efficacy" -genetics_overexpression_suppress hsa-mir-203 "Fatty Liver, Alcoholic" 29670525 over-expression of miR-203 inhibited the liver lipids accumulation and the progression of AFL by targeting Lipin1 -genetics_overexpression_suppress hsa-mir-27b Atrial Fibrillation 29671258 Atrial overexpression of microRNA-27b attenuates angiotensin II-induced atrial fibrosis and fibrillation by targeting ALK5. -genetics_overexpression_suppress hsa-mir-132 Heart Failure 29682535 Overexpression of microRNA-132 dramatically increased the antioxidant stress and antiapoptotic ability of H9C2 cells and decreased the expression of TGF-¦Â1 and smad3 -genetics_overexpression_suppress hsa-mir-140 Intervertebral Disc Degeneration 29901170 Overexpression of miR-140-5p inhibits lipopolysaccharide-induced human intervertebral disc inflammation and degeneration by downregulating toll-like receptor 4. -genetics_overexpression_suppress hsa-mir-7 "Carcinoma, Hepatocellular" 29936764 Overexpression of miR-7 can inhibit the proliferation and invasion ability of hepatocellular carcinoma cells HepG2 by downregulating Raf1 in vitro -genetics_overexpression_suppress hsa-mir-410 "Carcinoma, Hepatocellular" 30086463 overexpression of miR-133a suppressed biological behaviour of HCC through TGF-¦Â/Smad3 signaling pathway -other hsa-mir-142 "Leukemia, B-Cell" 12007417 A translocation that make MYC overexpression -other hsa-mir-143 Colon Neoplasms 14573789 reduced miRNA levels -other hsa-mir-145 Colon Neoplasms 14573789 reduced miRNA levels -other hsa-mir-17 Lymphoma 16096373 "Herein, we propose a model in which the mir-17 cluster prevents excessive E2F1 activity, and thereby apoptosis, in response to activation of c-Myc." -other hsa-mir-122 Hepatitis C Virus Infection 16141076 interaction with non-coding regions of Hepatitis C help its replication -other hsa-mir-375 Diabetes Mellitus 16195701 mir-375 was found to modulate glucose-stimulated insulin secretion and exocytosis. -other hsa-mir-29a Acquired Immunodeficiency Syndrome 16236258 miRNAs expressed in T-cells can repress nef function and thus influence disease progression. -other hsa-mir-29b-1 Acquired Immunodeficiency Syndrome 16236258 miRNAs expressed in T-cells can repress nef function and thus influence disease progression. -other hsa-mir-181a Hematologic Neoplasms 16249029 "The stress-induced modulation of hematopoietic miR-181a levels through AChE, PKC and PKA cascade(s) suggests using miRNA mimics for diverting the fate of hematopoietic tumor cells towards differentiation and/or apoptosis." -other hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 16885332 The finding that essentially all indolent CLLs have lost miR-15a/miR-16-1 expression suggests that this event is the initiating event in the pathogenesis of the indolent form of CLL. -other hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 16885332 The finding that essentially all indolent CLLs have lost miR-15a/miR-16-1 expression suggests that this event is the initiating event in the pathogenesis of the indolent form of CLL. -other hsa-mir-372 Neoplasms [unspecific] 17028596 "mir-372/373 shown to be oncogenes cooperating with Ras (Voorhoeve et al., 2006)" -other hsa-mir-373 Neoplasms [unspecific] 17028596 "mir-372/373 shown to be oncogenes cooperating with Ras (Voorhoeve et al., 2006)" -other hsa-mir-17 Lymphoma 17093929 These data demonstrate that OncomiR-1 accelerates lymphoma and promotes a more disseminated disease. -other hsa-mir-18a Lymphoma 17093929 These data demonstrate that OncomiR-1 accelerates lymphoma and promotes a more disseminated disease. -other hsa-mir-18b Lymphoma 17093929 These data demonstrate that OncomiR-1 accelerates lymphoma and promotes a more disseminated disease. -other hsa-mir-19a Lymphoma 17093929 These data demonstrate that OncomiR-1 accelerates lymphoma and promotes a more disseminated disease. -other hsa-mir-19b-1 Lymphoma 17093929 These data demonstrate that OncomiR-1 accelerates lymphoma and promotes a more disseminated disease. -other hsa-mir-19b-2 Lymphoma 17093929 These data demonstrate that OncomiR-1 accelerates lymphoma and promotes a more disseminated disease. -other hsa-mir-20a Lymphoma 17093929 These data demonstrate that OncomiR-1 accelerates lymphoma and promotes a more disseminated disease. -other hsa-mir-20b Lymphoma 17093929 These data demonstrate that OncomiR-1 accelerates lymphoma and promotes a more disseminated disease. -other hsa-mir-92a-1 Lymphoma 17093929 These data demonstrate that OncomiR-1 accelerates lymphoma and promotes a more disseminated disease. -other hsa-mir-92a-2 Lymphoma 17093929 These data demonstrate that OncomiR-1 accelerates lymphoma and promotes a more disseminated disease. -other hsa-mir-92b Lymphoma 17093929 These data demonstrate that OncomiR-1 accelerates lymphoma and promotes a more disseminated disease. -other hsa-mir-32 Viral Infectious Disease 17096367 "The authors found that a cellular miRNA, miR-32, mediated antiviral defense in human cells, and regulated primate foamy virus type I (PFV-1) proliferation." -other hsa-mir-17 "Lymphoma, Burkitt" 17135268 "We recently demonstrated that a polycistronic cluster of miRNAs, miR-17-92, is oncogenic in a mouse model for Burkitt's lymphoma." -other hsa-mir-18 "Lymphoma, Burkitt" 17135268 "We recently demonstrated that a polycistronic cluster of miRNAs, miR-17-92, is oncogenic in a mouse model for Burkitt's lymphoma." -other hsa-mir-19a "Lymphoma, Burkitt" 17135268 "We recently demonstrated that a polycistronic cluster of miRNAs, miR-17-92, is oncogenic in a mouse model for Burkitt's lymphoma." -other hsa-mir-19b-1 "Lymphoma, Burkitt" 17135268 "We recently demonstrated that a polycistronic cluster of miRNAs, miR-17-92, is oncogenic in a mouse model for Burkitt's lymphoma." -other hsa-mir-20a "Lymphoma, Burkitt" 17135268 "We recently demonstrated that a polycistronic cluster of miRNAs, miR-17-92, is oncogenic in a mouse model for Burkitt's lymphoma." -other hsa-mir-92-1 "Lymphoma, Burkitt" 17135268 "We recently demonstrated that a polycistronic cluster of miRNAs, miR-17-92, is oncogenic in a mouse model for Burkitt's lymphoma." -other hsa-mir-155 "Lymphoma, Burkitt" 17173072 "Our data provide evidence for two levels of regulation for mature miR-155 expression: one at the transcriptional level involving PKC and NF-kappaB, and one at the processing level. Burkitt lymphoma cells not only express low levels of BIC, but also prevent processing of BIC via an, as yet, unknown mechanism." -other hsa-mir-143 Hepatitis C Virus Infection 17188425 "miRNA-143 and -145 levels increase as disease progresses from chronic hepatitis to cirrhosis, suggesting that they may turn on inflammatory or fibrosis related genes and/or turn off tumor suppressor genes." -other hsa-mir-145 Hepatitis C Virus Infection 17188425 "miRNA-143 and -145 levels increase as disease progresses from chronic hepatitis to cirrhosis, suggesting that they may turn on inflammatory or fibrosis related genes and/or turn off tumor suppressor genes." -other hsa-mir-223 "Leukemia, Promyelocytic, Acute" 17217039 "The activation of both pathways of transcriptional regulation by the myeloid lineage-specific transcription factor C/EBPalpha (CCAAT/enhancer-binding protein-alpha), and posttranscriptional regulation by miR-223 appears essential for granulocytic differentiation and clinical response of acute promyelocytic leukemia (APL) blasts to all-trans retinoic acid (ATRA)." -other hsa-mir-155 Vascular Disease [unspecific] 17293455 "As predicted, miRNA-155 transduction greatly reduced both myeloid and erythroid colony formation of normal human HSPCs." -other hsa-mir-34a Neuroblastoma 17297439 MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. -other hsa-mir-17 Lung Neoplasms 17384677 "In marked contrast, antisense ONs against miR-18a and miR-19a did not exhibit such inhibitory effects, whereas inhibition of miR-92-1 resulted in only modest reduction of cell growth, showing significant distinctions among miRNAs of the miR-17-92 cluster in terms of their roles in cancer cell growth." -other hsa-mir-18 Lung Neoplasms 17384677 "In marked contrast, antisense ONs against miR-18a and miR-19a did not exhibit such inhibitory effects, whereas inhibition of miR-92-1 resulted in only modest reduction of cell growth, showing significant distinctions among miRNAs of the miR-17-92 cluster in terms of their roles in cancer cell growth." -other hsa-mir-18a Lung Neoplasms 17384677 "In marked contrast, antisense ONs against miR-18a and miR-19a did not exhibit such inhibitory effects, whereas inhibition of miR-92-1 resulted in only modest reduction of cell growth, showing significant distinctions among miRNAs of the miR-17-92 cluster in terms of their roles in cancer cell growth." -other hsa-mir-19a Lung Neoplasms 17384677 "In marked contrast, antisense ONs against miR-18a and miR-19a did not exhibit such inhibitory effects, whereas inhibition of miR-92-1 resulted in only modest reduction of cell growth, showing significant distinctions among miRNAs of the miR-17-92 cluster in terms of their roles in cancer cell growth." -other hsa-mir-19b-1 Lung Neoplasms 17384677 "In marked contrast, antisense ONs against miR-18a and miR-19a did not exhibit such inhibitory effects, whereas inhibition of miR-92-1 resulted in only modest reduction of cell growth, showing significant distinctions among miRNAs of the miR-17-92 cluster in terms of their roles in cancer cell growth." -other hsa-mir-20a Lung Neoplasms 17384677 "In marked contrast, antisense ONs against miR-18a and miR-19a did not exhibit such inhibitory effects, whereas inhibition of miR-92-1 resulted in only modest reduction of cell growth, showing significant distinctions among miRNAs of the miR-17-92 cluster in terms of their roles in cancer cell growth." -other hsa-mir-92-1 Lung Neoplasms 17384677 "In marked contrast, antisense ONs against miR-18a and miR-19a did not exhibit such inhibitory effects, whereas inhibition of miR-92-1 resulted in only modest reduction of cell growth, showing significant distinctions among miRNAs of the miR-17-92 cluster in terms of their roles in cancer cell growth." -other hsa-mir-1-1 Arrhythmia 17401374 These data strongly indicate that miR-1 is an arrhythmogenic or proarrhythmic factor that is detrimental to the ischemic heart. Delivery of miR-1 into healthy hearts was also arrhythmogenic. -other hsa-mir-1-2 Arrhythmia 17401374 These data strongly indicate that miR-1 is an arrhythmogenic or proarrhythmic factor that is detrimental to the ischemic heart. Delivery of miR-1 into healthy hearts was also arrhythmogenic. -other hsa-mir-155 Down Syndrome 17468766 "Because miR-155 maps to chromosome 21, Setupathy et al. speculate that miR-155 overexpression in trisomics'a which they confirmed experimentally a accounts for the lower levels of diastolic and systolic blood pressure associated with Down syndrome." -other hsa-mir-194-1 Urinary Bladder Cancer 17470785 "The list of miRNAs at or near sites commonly altered in human cancers includes mir-215 and mir-194-1, which are <0.17 kb from D1Mit208, a marker that defines the peak of the colon Scc3 locus on Chr 1. Homologous human miRNAs are located inside the FRA1H at Chr 1q42.1; this fragile site is an HPV16 integration site involved in cervical cancer." -other hsa-mir-215 Urinary Bladder Cancer 17470785 "The list of miRNAs at or near sites commonly altered in human cancers includes mir-215 and mir-194-1, which are <0.17 kb from D1Mit208, a marker that defines the peak of the colon Scc3 locus on Chr 1. Homologous human miRNAs are located inside the FRA1H at Chr 1q42.1; this fragile site is an HPV16 integration site involved in cervical cancer." -other hsa-mir-21 "Cardiomyopathy, Hypertrophic" 17525252 Modulating miR-21 expression via antisense-mediated depletion (knockdown) had a significant negative effect on cardiomyocyte hypertrophy. -other hsa-mir-34a Pancreatic Neoplasms 17540599 "Therefore, it is likely that an important function of miR-34a is the modulation and fine-tuning of the gene expression program initiated by p53." -other hsa-let-7a Vascular Disease [unspecific] 17540974 The let-7 family and mir-27b appear to be attractive targets for modulating angiogenesis. -other hsa-let-7b Vascular Disease [unspecific] 17540974 The let-7 family and mir-27b appear to be attractive targets for modulating angiogenesis. -other hsa-let-7c Vascular Disease [unspecific] 17540974 The let-7 family and mir-27b appear to be attractive targets for modulating angiogenesis. -other hsa-let-7d Vascular Disease [unspecific] 17540974 The let-7 family and mir-27b appear to be attractive targets for modulating angiogenesis. -other hsa-let-7e Vascular Disease [unspecific] 17540974 The let-7 family and mir-27b appear to be attractive targets for modulating angiogenesis. -other hsa-let-7f Vascular Disease [unspecific] 17540974 The let-7 family and mir-27b appear to be attractive targets for modulating angiogenesis. -other hsa-let-7g Vascular Disease [unspecific] 17540974 The let-7 family and mir-27b appear to be attractive targets for modulating angiogenesis. -other hsa-let-7i Vascular Disease [unspecific] 17540974 The let-7 family and mir-27b appear to be attractive targets for modulating angiogenesis. -other hsa-let-7a Neoplasms [unspecific] 17554199 Other p53-induced miRNAs identified here may also have tumor suppressive potential as they are known to suppress the anti-apoptotic factor Bcl2 (miR-15a/16) and the oncogenes RAS and HMGA2 (let-7a). -other hsa-mir-17 Lymphoma 17608773 "The c13orf25/miR-17 cluster, which is responsible for 13q31-q32 amplification in malignant lymphoma, contains the microRNA-17-18-19-20-92 polycistron." -other hsa-mir-18 Lymphoma 17608773 "The c13orf25/miR-17 cluster, which is responsible for 13q31-q32 amplification in malignant lymphoma, contains the microRNA-17-18-19-20-92 polycistron." -other hsa-mir-19a Lymphoma 17608773 "The c13orf25/miR-17 cluster, which is responsible for 13q31-q32 amplification in malignant lymphoma, contains the microRNA-17-18-19-20-92 polycistron." -other hsa-mir-19b-1 Lymphoma 17608773 "The c13orf25/miR-17 cluster, which is responsible for 13q31-q32 amplification in malignant lymphoma, contains the microRNA-17-18-19-20-92 polycistron." -other hsa-mir-20a Lymphoma 17608773 "The c13orf25/miR-17 cluster, which is responsible for 13q31-q32 amplification in malignant lymphoma, contains the microRNA-17-18-19-20-92 polycistron." -other hsa-mir-92-1 Lymphoma 17608773 "The c13orf25/miR-17 cluster, which is responsible for 13q31-q32 amplification in malignant lymphoma, contains the microRNA-17-18-19-20-92 polycistron." -other hsa-mir-370 Neoplasms [unspecific] 17621267 "Thus, IL-6 may contribute to tumor growth by modulation of expression of selected miRNAs, such as miR-370. These studies define a mechanism by which inflammation-associated cytokines can epigenetically modulate gene expression and directly contribute to tumor biology." -other hsa-mir-16 Leukemia 17683260 "several confirmed miRNA targets appear in our high-confidence set, such as the interactions between miR-92 and the signal transduction gene MAP2K4, as well as the relationship between miR-16 and BCL2, an anti-apoptotic gene which has been implicated in chronic lymphocytic leukemia." -other hsa-mir-92 Leukemia 17683260 "several confirmed miRNA targets appear in our high-confidence set, such as the interactions between miR-92 and the signal transduction gene MAP2K4, as well as the relationship between miR-16 and BCL2, an anti-apoptotic gene which has been implicated in chronic lymphocytic leukemia." -other hsa-mir-372 Germ Cell And Embryonal Neoplasms 17695719 "we identified miR-372 and miR-373, each permitting proliferation and tumorigenesis of primary human cells that harbor both oncogenic RAS and active wild-type p53." -other hsa-mir-373 Germ Cell And Embryonal Neoplasms 17695719 "we identified miR-372 and miR-373, each permitting proliferation and tumorigenesis of primary human cells that harbor both oncogenic RAS and active wild-type p53." -other hsa-mir-21 Colon Neoplasms 17702597 "In colon cancer cells, at a clinically relevant concentration,the drug up-regulates or down-regulates in vitro the expression of 19 and 3 miR genes, respectively, by a factor of not less than two-fold. In some instances, 5-FU up-regulates miR genes that are already over-expressed in neoplastic tissues, including, for example, miR-21 that is associated with anti-apoptotic functions characterizing malignant cells. " -other hsa-mir-124a Teratocarcinoma 17716626 "Based on these observations, it is suggested that the miR-302 cluster and miR-124a may be useful molecular indicators in the assessmentof degree of undifferentiation and/or differentiation in the course of neuronal differentiation." -other hsa-mir-155 Lymphoma 17727326 "Cancer-associated microRNAs can act as both tumour suppressor molecules (e.g., miR-15a and miR-16-1) and have oncogenic properties (e.g., miR-155 and miR-17-92 cluster)." -other hsa-mir-15a Lymphoma 17727326 "Cancer-associated microRNAs can act as both tumour suppressor molecules (e.g., miR-15a and miR-16-1) and have oncogenic properties (e.g., miR-155 and miR-17-92 cluster)." -other hsa-mir-16-1 Lymphoma 17727326 "Cancer-associated microRNAs can act as both tumour suppressor molecules (e.g., miR-15a and miR-16-1) and have oncogenic properties (e.g., miR-155 and miR-17-92 cluster)." -other hsa-mir-17 Lymphoma 17727326 "Cancer-associated microRNAs can act as both tumour suppressor molecules (e.g., miR-15a and miR-16-1) and have oncogenic properties (e.g., miR-155 and miR-17-92 cluster)." -other hsa-mir-18 Lymphoma 17727326 "Cancer-associated microRNAs can act as both tumour suppressor molecules (e.g., miR-15a and miR-16-1) and have oncogenic properties (e.g., miR-155 and miR-17-92 cluster)." -other hsa-mir-19a Lymphoma 17727326 "Cancer-associated microRNAs can act as both tumour suppressor molecules (e.g., miR-15a and miR-16-1) and have oncogenic properties (e.g., miR-155 and miR-17-92 cluster)." -other hsa-mir-19b-1 Lymphoma 17727326 "Cancer-associated microRNAs can act as both tumour suppressor molecules (e.g., miR-15a and miR-16-1) and have oncogenic properties (e.g., miR-155 and miR-17-92 cluster)." -other hsa-mir-20a Lymphoma 17727326 "Cancer-associated microRNAs can act as both tumour suppressor molecules (e.g., miR-15a and miR-16-1) and have oncogenic properties (e.g., miR-155 and miR-17-92 cluster)." -other hsa-mir-92-1 Lymphoma 17727326 "Cancer-associated microRNAs can act as both tumour suppressor molecules (e.g., miR-15a and miR-16-1) and have oncogenic properties (e.g., miR-155 and miR-17-92 cluster)." -other hsa-mir-133b Parkinson Disease 17761882 "Expression of one of these precursor miRNAs, miR-133b, was specifically enriched in the midbrain and deficient in the context of Parkinson's disease patient samples, as determined by ribonuclease (RNase) protection assays, qPCR, and Northern blotting for mature miR-133b." -other hsa-mir-1-1 Arrhythmia 17786230 the finding that increasing or decreasing miR-1 expression causes lethal cardiac arrhythmias highlights not only the exquisite sensitivity of the heart to the levels of expression of this miRNA but also poses significant hurdles to the possible therapeutic manipulation of miR-1 levels in the settings of cardiac conduction abnormalities or myocardial repair. -other hsa-mir-1-2 Arrhythmia 17786230 the finding that increasing or decreasing miR-1 expression causes lethal cardiac arrhythmias highlights not only the exquisite sensitivity of the heart to the levels of expression of this miRNA but also poses significant hurdles to the possible therapeutic manipulation of miR-1 levels in the settings of cardiac conduction abnormalities or myocardial repair. -other hsa-mir-133a-1 Arrhythmia 17786230 "These results suggest an active role for miR-133 in the inhibition of cardiac hypertrophy. Xiao et al. reported miR-133 to play a role in cardiac conductance abnormalities during diabetes by lowering the protein levels of ether-a-go-go§Ò§ÙCrelated gene (ERG), which encodes a key K+ channel (IKr) responsible for rapid delayed rectifier K+ current in cardiac cells." -other hsa-mir-133a-1 "Cardiomyopathy, Hypertrophic" 17786230 "These results suggest an active role for miR-133 in the inhibition of cardiac hypertrophy. Xiao et al. reported miR-133 to play a role in cardiac conductance abnormalities during diabetes by lowering the protein levels of ether-a-go-go§Ò§ÙCrelated gene (ERG), which encodes a key K+ channel (IKr) responsible for rapid delayed rectifier K+ current in cardiac cells." -other hsa-mir-133a-2 Arrhythmia 17786230 "These results suggest an active role for miR-133 in the inhibition of cardiac hypertrophy. Xiao et al. reported miR-133 to play a role in cardiac conductance abnormalities during diabetes by lowering the protein levels of ether-a-go-go§Ò§ÙCrelated gene (ERG), which encodes a key K+ channel (IKr) responsible for rapid delayed rectifier K+ current in cardiac cells." -other hsa-mir-133a-2 "Cardiomyopathy, Hypertrophic" 17786230 "These results suggest an active role for miR-133 in the inhibition of cardiac hypertrophy. Xiao et al. reported miR-133 to play a role in cardiac conductance abnormalities during diabetes by lowering the protein levels of ether-a-go-go§Ò§ÙCrelated gene (ERG), which encodes a key K+ channel (IKr) responsible for rapid delayed rectifier K+ current in cardiac cells." -other hsa-mir-208a Endomyocardial Fibrosis 17786230 "Clearly, miR-208 is also essential for expression of the genes involved in cardiac fibrosis and hypertrophic growth." -other hsa-mir-208a Hypertrophy 17786230 "Clearly, miR-208 is also essential for expression of the genes involved in cardiac fibrosis and hypertrophic growth." -other hsa-mir-21 Heart Diseases [unspecific] 17786230 "Another miRNA consistently induced by cardiac stress, miR-21, appears to function as a regulator of cardiac growth and fetal gene activation in primary cardiomyocytes in vitro although some confusion remains regarding its exact role." -other hsa-mir-155 Kaposi Sarcoma 17881434 "Together, these findings indicate that KSHV miR-K12-11 is an ortholog of miR-155." -other hsa-mir-150 Leukemia 17923094 "Combining loss- and gain-of-function gene targeting approaches for miR-150 with conditional and partial ablation of c-Myb, we show that miR-150 indeed controls c-Myb expression in vivo in a dose-dependent manner over a narrow range of miRNA and c-Myb concentrations and that this dramatically affects lymphocyte development and response." -other hsa-mir-17 "Leukemia, B-Cell" 17940623 "These data suggested a direct involvement of this miRNA cluster in tumorigenesis. The miR-17-92 cluster encompassing six miRNAs: miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1 and miR-92-1." -other hsa-mir-18a "Leukemia, B-Cell" 17940623 "These data suggested a direct involvement of this miRNA cluster in tumorigenesis. The miR-17-92 cluster encompassing six miRNAs: miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1 and miR-92-1." -other hsa-mir-19a "Leukemia, B-Cell" 17940623 "These data suggested a direct involvement of this miRNA cluster in tumorigenesis. The miR-17-92 cluster encompassing six miRNAs: miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1 and miR-92-1." -other hsa-mir-19b-1 "Leukemia, B-Cell" 17940623 "These data suggested a direct involvement of this miRNA cluster in tumorigenesis. The miR-17-92 cluster encompassing six miRNAs: miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1 and miR-92-1." -other hsa-mir-20a "Leukemia, B-Cell" 17940623 "These data suggested a direct involvement of this miRNA cluster in tumorigenesis. The miR-17-92 cluster encompassing six miRNAs: miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1 and miR-92-1." -other hsa-mir-92a-1 "Leukemia, B-Cell" 17940623 "These data suggested a direct involvement of this miRNA cluster in tumorigenesis. The miR-17-92 cluster encompassing six miRNAs: miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1 and miR-92-1." -other hsa-mir-122 Lipid Metabolism Disorder 17965831 Inhibition of miR-122 resulted in decreased levels of cholesterol in the plasma and improved liver function in obese mice. -other hsa-mir-155 Kidney Diseases [unspecific] 17965831 miR-155 was shown to decrease the expression of angiotensin II type 1 receptor in human primary fibroblasts [175]. This suggests that miR-155 may regulate a diverse set of physiological functions including fluid homeostasis and renal function. -other hsa-mir-155 Lung Neoplasms 17965831 "miR-155 has also been implicated in a number of cancers including Burkitt_s lymphoma, Hodgkin lymphoma and lung cancer." -other hsa-mir-155 "Lymphoma, Burkitt" 17965831 "miR-155 has also been implicated in a number of cancers including Burkitt_s lymphoma, Hodgkin lymphoma and lung cancer." -other hsa-mir-155 "Lymphoma, Hodgkin" 17965831 "miR-155 has also been implicated in a number of cancers including Burkitt_s lymphoma, Hodgkin lymphoma and lung cancer." -other hsa-mir-208a "Cardiomyopathy, Hypertrophic" 17965831 "miR-208 was recently shown to enhance stress-related cardiac muscle growth by up-regulating a contractile protein, bMHC, possibly by repressing translation of thyroid hormone receptor-associated protein 1 (THRAP1)." -other hsa-mir-372 Testicular Neoplasms 17965831 miR-372 and miR-373 have been implicated in testicular germ cell tumours. -other hsa-mir-373 Testicular Neoplasms 17965831 miR-372 and miR-373 have been implicated in testicular germ cell tumours. -other hsa-mir-375 Diabetes Mellitus 17965831 "For instance, miR-375 was shown to directly regulate insulin secretion from pancreatic islet cells. Overexpression of miR-375 led to an enhanced inhibition of insulin exocytosis, whereas anti-sense to miR-375 enhanced insulin secretion by blocking the effects of the miRNA." -other hsa-mir-222 Polycythemia Vera 17976518 "Comparative analyses of control and PV EPs suggested increased levels of miR-451, miR-16, miR-21, and miR-26b and decreased levels of miR-150 and miR-221 in PV group, Expression of miR-150 progressively declined with erythroid differentiation, its expression decreased ninefold (p < 0.05) from days 7 to 11." -other hsa-mir-339 Polycythemia Vera 17976518 biphasic regulation -other hsa-mir-378a Polycythemia Vera 17976518 "Comparative analyses of control and PV EPs suggested increased levels of miR-451, miR-16, miR-21, and miR-26b and decreased levels of miR-150 and miR-221 in PV group, Expression of miR-150 progressively declined with erythroid differentiation, its expression decreased ninefold (p < 0.05) from days 7 to 11." -other hsa-mir-17 "Leukemia, B-Cell" 17989227 "the miR-17 cluster (8, 9) synergizes with MYC to induce B cell lymphoma." -other hsa-mir-132 Neoplasms [unspecific] 18075311 "In this review, we will discuss the specific roles of miRNA-(miR-)132 and miR-219 in the SCN, as well as a more general outlook on this newly elucidated layer of circadian clock regulation: inducible translation control via miRNAs." -other hsa-mir-219 Neoplasms [unspecific] 18075311 "In this review, we will discuss the specific roles of miRNA-(miR-)132 and miR-219 in the SCN, as well as a more general outlook on this newly elucidated layer of circadian clock regulation: inducible translation control via miRNAs." -other hsa-let-7g Colon Neoplasms 18172508 Non-coding MicroRNAs hsa-let-7g and hsa-miR-181b are Associated with Chemoresponse to S-1 in Colon Cancer. -other hsa-mir-181b Colon Neoplasms 18172508 Non-coding MicroRNAs hsa-let-7g and hsa-miR-181b are Associated with Chemoresponse to S-1 in Colon Cancer. -other hsa-let-7c Colon Neoplasms 18188765 "Let-7C was clearly present in lung, prostate, and colon cancers but undetectable in ovary and thyroid cancer samples" -other hsa-mir-155 Kaposi Sarcoma 18191785 "Two new papers provide strong evidence that a KSHV-encoded microRNA and mir-155 share a common set of mRNA targets and binding sites, implying a possible link between viral- and non-viral-mediated tumorigenesis." -other hsa-mir-373 Prostate Neoplasms 18193036 "Taken together, our findings indicate that miRNAs are involved in tumour migration and invasion, and implicate miR-373 and miR-520c as metastasis-promoting miRNAs." -other hsa-mir-214 Ovarian Neoplasms 18199536 These findings indicate that deregulation of miRNAs is a recurrent event in human ovarian cancer and that miR-214 induces cell survival and cisplatin resistance primarily through targeting the PTEN/Akt pathway. -other hsa-mir-10b Neoplasms [unspecific] 18256538 pro-metastatic -other hsa-mir-181a Inflammation 18291670 "MiRNAs are implicated in establishing and maintaining the cell fate of immune cells (e.g. miR-181a and miR-223), and they are involved in innate immunity by regulating Toll-like receptor signaling and ensuing cytokine response (e.g. miR-146)." -other hsa-mir-203 Inflammation 18291670 "MiRNAs are implicated in establishing and maintaining the cell fate of immune cells (e.g. miR-181a and miR-223), and they are involved in innate immunity by regulating Toll-like receptor signaling and ensuing cytokine response (e.g. miR-146)." -other hsa-mir-137 Melanoma 18316599 MicroRNA-137 targets microphthalmia-associated transcription factor in melanoma cell lines. -other hsa-mir-17 Lymphoma 18329372 These results provide key insights into the physiologic functions of this family of microRNAs and suggest a link between the oncogenic properties of miR-17 approximately 92 and its functionsduring B lymphopoiesis and lung development. -other hsa-mir-18 Lymphoma 18329372 These results provide key insights into the physiologic functions of this family of microRNAs and suggest a link between the oncogenic properties of miR-17 approximately 92 and its functionsduring B lymphopoiesis and lung development. -other hsa-mir-19a Lymphoma 18329372 These results provide key insights into the physiologic functions of this family of microRNAs and suggest a link between the oncogenic properties of miR-17 approximately 92 and its functionsduring B lymphopoiesis and lung development. -other hsa-mir-19b-1 Lymphoma 18329372 These results provide key insights into the physiologic functions of this family of microRNAs and suggest a link between the oncogenic properties of miR-17 approximately 92 and its functionsduring B lymphopoiesis and lung development. -other hsa-mir-20a Lymphoma 18329372 These results provide key insights into the physiologic functions of this family of microRNAs and suggest a link between the oncogenic properties of miR-17 approximately 92 and its functionsduring B lymphopoiesis and lung development. -other hsa-mir-92-1 Lymphoma 18329372 These results provide key insights into the physiologic functions of this family of microRNAs and suggest a link between the oncogenic properties of miR-17 approximately 92 and its functionsduring B lymphopoiesis and lung development. -other hsa-mir-146a "Lymphoma, Burkitt" 18347435 induced by EBV-encoded latent membrane protein 1 (LMP1) -other hsa-mir-155 "Lymphoma, Burkitt" 18347435 induced by EBV-encoded latent membrane protein 1 (LMP1) -other hsa-mir-155 "Lymphoma, Burkitt" 18354490 process BIC -other hsa-mir-206 Vascular Hypertrophy 18381085 The review is also intended to serve as a comprehensive resource for miR-206 with the hope of encouraging further research on the role of miR-206 in skeletal muscle. -other hsa-mir-200a Neoplasms [unspecific] 18381893 the epithelial-to-mesenchymal transition -other hsa-mir-200b Neoplasms [unspecific] 18381893 the epithelial-to-mesenchymal transition -other hsa-mir-200c Neoplasms [unspecific] 18381893 the epithelial-to-mesenchymal transition -other hsa-mir-146b Inflammation 18390754 "Overall, these studies indicate that rapid increase in miRNA-146a expression provides a novel mechanism for the negative regulation of severe inflammation during the innate immune response." -other hsa-mir-146a Osteoarthritis 18438844 This study shows that miR-146 is expressed in RA synovial tissue and that its expression is induced by stimulation with TNFalpha and IL-1beta. Further studies are required to elucidate the function of miR-146 in these tissues. -other hsa-mir-100 Ovarian Neoplasms 18451233 normal -other hsa-mir-125a Ovarian Neoplasms 18451233 normal -other hsa-mir-145 Ovarian Neoplasms 18451233 normal -other hsa-mir-21 Ovarian Neoplasms 18451233 normal -other hsa-mir-99a Ovarian Neoplasms 18451233 normal -other hsa-mir-7 Glioblastoma 18483236 microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma. -other hsa-mir-141 "Carcinoma, Rectal" 18483486 "Here, we report that ZEB1 directly suppresses transcription of microRNA-200 family members miR-141 and miR-200c, which strongly activate epithelial differentiation in pancreatic, colorectal and breast cancer cells." -other hsa-mir-200c "Carcinoma, Rectal" 18483486 "Here, we report that ZEB1 directly suppresses transcription of microRNA-200 family members miR-141 and miR-200c, which strongly activate epithelial differentiation in pancreatic, colorectal and breast cancer cells." -other hsa-mir-150 Leukemia 18536574 "Using animal models engineered to overexpress miR-150, miR-17 approximately 92 and miR-155 or to be deficient for miR-223, miR-155 and miR-17 approximately 92 expression, several groups have now shown that miRNAs are critical for B-lymphocyte development (miR-150 and miR-17 approximately 92), granulopoiesis (miR-223), immune function (miR-155) and B-lymphoproliferative disorders (miR-155 and miR-17 approximately 92)." -other hsa-mir-155 Leukemia 18536574 "Using animal models engineered to overexpress miR-150, miR-17 approximately 92 and miR-155 or to be deficient for miR-223, miR-155 and miR-17 approximately 92 expression, several groups have now shown that miRNAs are critical for B-lymphocyte development (miR-150 and miR-17 approximately 92), granulopoiesis (miR-223), immune function (miR-155) and B-lymphoproliferative disorders (miR-155 and miR-17 approximately 92)." -other hsa-mir-17 Leukemia 18536574 "Using animal models engineered to overexpress miR-150, miR-17 approximately 92 and miR-155 or to be deficient for miR-223, miR-155 and miR-17 approximately 92 expression, several groups have now shown that miRNAs are critical for B-lymphocyte development (miR-150 and miR-17 approximately 92), granulopoiesis (miR-223), immune function (miR-155) and B-lymphoproliferative disorders (miR-155 and miR-17 approximately 92)." -other hsa-mir-18 Leukemia 18536574 "Using animal models engineered to overexpress miR-150, miR-17 approximately 92 and miR-155 or to be deficient for miR-223, miR-155 and miR-17 approximately 92 expression, several groups have now shown that miRNAs are critical for B-lymphocyte development (miR-150 and miR-17 approximately 92), granulopoiesis (miR-223), immune function (miR-155) and B-lymphoproliferative disorders (miR-155 and miR-17 approximately 92)." -other hsa-mir-19a Leukemia 18536574 "Using animal models engineered to overexpress miR-150, miR-17 approximately 92 and miR-155 or to be deficient for miR-223, miR-155 and miR-17 approximately 92 expression, several groups have now shown that miRNAs are critical for B-lymphocyte development (miR-150 and miR-17 approximately 92), granulopoiesis (miR-223), immune function (miR-155) and B-lymphoproliferative disorders (miR-155 and miR-17 approximately 92)." -other hsa-mir-19b-1 Leukemia 18536574 "Using animal models engineered to overexpress miR-150, miR-17 approximately 92 and miR-155 or to be deficient for miR-223, miR-155 and miR-17 approximately 92 expression, several groups have now shown that miRNAs are critical for B-lymphocyte development (miR-150 and miR-17 approximately 92), granulopoiesis (miR-223), immune function (miR-155) and B-lymphoproliferative disorders (miR-155 and miR-17 approximately 92)." -other hsa-mir-20a Leukemia 18536574 "Using animal models engineered to overexpress miR-150, miR-17 approximately 92 and miR-155 or to be deficient for miR-223, miR-155 and miR-17 approximately 92 expression, several groups have now shown that miRNAs are critical for B-lymphocyte development (miR-150 and miR-17 approximately 92), granulopoiesis (miR-223), immune function (miR-155) and B-lymphoproliferative disorders (miR-155 and miR-17 approximately 92)." -other hsa-mir-223 Leukemia 18536574 "Using animal models engineered to overexpress miR-150, miR-17 approximately 92 and miR-155 or to be deficient for miR-223, miR-155 and miR-17 approximately 92 expression, several groups have now shown that miRNAs are critical for B-lymphocyte development (miR-150 and miR-17 approximately 92), granulopoiesis (miR-223), immune function (miR-155) and B-lymphoproliferative disorders (miR-155 and miR-17 approximately 92)." -other hsa-mir-92-1 Leukemia 18536574 "Using animal models engineered to overexpress miR-150, miR-17 approximately 92 and miR-155 or to be deficient for miR-223, miR-155 and miR-17 approximately 92 expression, several groups have now shown that miRNAs are critical for B-lymphocyte development (miR-150 and miR-17 approximately 92), granulopoiesis (miR-223), immune function (miR-155) and B-lymphoproliferative disorders (miR-155 and miR-17 approximately 92)." -other hsa-let-7f Vascular Disease [unspecific] 18550634 "Meanwhile, a few specific miRNAs that regulate endothelial cell functions and angiogenesis have been described. Let7-f, miR-27b, and mir-130a were identified as pro-angiogenic miRNAs" -other hsa-mir-130a Vascular Disease [unspecific] 18550634 "Meanwhile, a few specific miRNAs that regulate endothelial cell functions and angiogenesis have been described. Let7-f, miR-27b, and mir-130a were identified as pro-angiogenic miRNAs" -other hsa-mir-27b Vascular Disease [unspecific] 18550634 "Meanwhile, a few specific miRNAs that regulate endothelial cell functions and angiogenesis have been described. Let7-f, miR-27b, and mir-130a were identified as pro-angiogenic miRNAs" -other hsa-mir-122 Hepatitis C Virus Infection 18550664 miR-122: Liver-specific microRNA miR-122 enhances the replication of hepatitis C virus in nonhepatic cells -other hsa-mir-198 Schizophrenia 18552348 "Human microRNAs (Hsa-mir-198 and Hsa-mir-206) are predicted to bind to influenza, rubella, or poliovirus genes. Certain genes associated with schizophrenia, including those also concerned with neurophysiology, are intimately related to the life cycles of the pathogens implicated in the disease." -other hsa-mir-206 Schizophrenia 18552348 "Human microRNAs (Hsa-mir-198 and Hsa-mir-206) are predicted to bind to influenza, rubella, or poliovirus genes. Certain genes associated with schizophrenia, including those also concerned with neurophysiology, are intimately related to the life cycles of the pathogens implicated in the disease." -other hsa-mir-223 "Carcinoma, Hepatocellular" 18555017 miR-223: MicroRNA-223 is commonly reproessed in hepatocellular carcinoma and potentiates expression of Stathmin1 -other hsa-let-7a-1 Neoplasms [unspecific] 18560417 let-7a: A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication -other hsa-let-7a-2 Neoplasms [unspecific] 18560417 let-7a: A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication -other hsa-let-7a-3 Neoplasms [unspecific] 18560417 let-7a: A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication -other hsa-let-7b Neoplasms [unspecific] 18560417 let-7b: A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication -other hsa-let-7c Neoplasms [unspecific] 18560417 let-7c: A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication -other hsa-let-7d Neoplasms [unspecific] 18560417 let-7d: A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication -other hsa-let-7e Neoplasms [unspecific] 18560417 let-7e: A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication -other hsa-let-7f-1 Neoplasms [unspecific] 18560417 let-7f: A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication -other hsa-let-7f-2 Neoplasms [unspecific] 18560417 let-7f: A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication -other hsa-let-7g Neoplasms [unspecific] 18560417 let-7g: A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication -other hsa-let-7i Neoplasms [unspecific] 18560417 let-7i: A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication -other hsa-mir-124-1 Glioblastoma 18577219 miR-124: miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells -other hsa-mir-124-2 Glioblastoma 18577219 miR-124: miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells -other hsa-mir-124-3 Glioblastoma 18577219 miR-124: miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells -other hsa-mir-137 Glioblastoma 18577219 miR-137: miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells -other hsa-mir-100 Heart Failure 18582896 "To pursue the observation that changes in expression levels of individual miRNAs are functionally relevant, microRNA mimics and inhibitors to miR-92, miR-100 and miR-133b were expressed in primary cultures of neonatal rat cardiac myocytes." -other hsa-mir-133b Heart Failure 18582896 "To pursue the observation that changes in expression levels of individual miRNAs are functionally relevant, microRNA mimics and inhibitors to miR-92, miR-100 and miR-133b were expressed in primary cultures of neonatal rat cardiac myocytes." -other hsa-mir-92 Heart Failure 18582896 "To pursue the observation that changes in expression levels of individual miRNAs are functionally relevant, microRNA mimics and inhibitors to miR-92, miR-100 and miR-133b were expressed in primary cultures of neonatal rat cardiac myocytes." -other hsa-mir-126 Lung Neoplasms 18602365 miR-126: MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines -other hsa-mir-451a Breast Neoplasms 18645025 miR-451: Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin -other hsa-mir-126 Colon Neoplasms 18663744 miR-126: miR-126 suppresses the growth of neoplastic cells -other hsa-mir-150 Leukemia 18667440 Our findings suggest that c-Myb is an evolutionally conserved target of miR-150 and miR-150/c-Myb interaction is important for embryonic development and possibly oncogenesis. -other hsa-mir-145 Colon Neoplasms 18676867 miR-145: miR-145 potently suppressed growth of three different colon carcinoma cell lines -other hsa-mir-498 Colon Neoplasms 18676867 miR-498: correlated with the probability of recurrence-free survival -other hsa-mir-126 Myocardial Infarction 18694565 We show that an endothelial cell-restricted microRNA (miR-126) mediates developmental angiogenesis in vivo. -other hsa-mir-17 Neoplasms [unspecific] 18700987 miR-17-5p: The miR-17-5p microRNA is able to act as both an oncogene and a tumor suppressor in different cellular contexts -other hsa-mir-181a-2 Glioma 18710654 miR-181a: mir suppressor -other hsa-mir-181b-1 Glioma 18710654 miR-181b: mir suppressor -other hsa-mir-181b-2 Glioma 18710654 miR-181b: mir suppressor -other hsa-mir-302a Skin Neoplasms 18755840 miR-302: Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state -other hsa-mir-302b Skin Neoplasms 18755840 miR-302: Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state -other hsa-mir-302c Skin Neoplasms 18755840 miR-302: Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state -other hsa-mir-302d Skin Neoplasms 18755840 miR-302: Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state -other hsa-mir-210 Breast Neoplasms 18755890 "miR-210: associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer" -other hsa-mir-516a-1 Breast Neoplasms 18755890 "miR-516-3p: associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer" -other hsa-mir-516a-2 Breast Neoplasms 18755890 "miR-516-3p: associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer" -other hsa-mir-516b-1 Breast Neoplasms 18755890 "miR-516-3p: associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer" -other hsa-mir-516b-2 Breast Neoplasms 18755890 "miR-516-3p: associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer" -other hsa-mir-7-1 Breast Neoplasms 18755890 "miR-7: associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer" -other hsa-mir-7-2 Breast Neoplasms 18755890 "miR-7: associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer" -other hsa-mir-7-3 Breast Neoplasms 18755890 "miR-7: associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer" -other hsa-mir-221 Glioblastoma 18759060 Up-regulation of micro-RNA-221 (miRNA-221; chr Xp11.3) and caspase-3 accompanies down-regulation of the survivin-1 homolog BIRC1 (NAIP) in glioblastoma multiforme (GBM). -other hsa-mir-27a Gastric Neoplasms 18789835 miR-27a: MicroRNA-27a functions as an oncogene in gastric adenocarcinoma by targeting prohibitin -other hsa-mir-221 Breast Neoplasms 18790736 miR-221: MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer -other hsa-mir-222 Breast Neoplasms 18790736 miR-222: MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer -other hsa-mir-21 Gastric Neoplasms 18794849 miR-21: miR-21 plays a pivotal role in gastric cancer pathogenesis and progression -other hsa-mir-34b "Lymphoma, Burkitt" 18802929 These results indicate for the first time that hsa-mir-34b may influence c-Myc expression in Burkitt lymphoma as the more common aberrant control exercised by the immunoglobulin enhancer locus. -other hsa-mir-34a Gastric Neoplasms 18803879 miR-34: tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres -other hsa-mir-34b Gastric Neoplasms 18803879 miR-34: tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres -other hsa-mir-34c Gastric Neoplasms 18803879 miR-34: tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres -other hsa-mir-21 Glioblastoma 18829576 miR-21: MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma -other hsa-mir-126 "Leukemia, Myeloid, Acute" 18832181 "miR-126: discriminate CBF, t(15;17), and MLL-rearrangement AMLs" -other hsa-mir-17 "Leukemia, Myeloid, Acute" 18832181 "miR-17-5p: discriminate CBF, t(15;17), and MLL-rearrangement AMLs" -other hsa-mir-20a "Leukemia, Myeloid, Acute" 18832181 "miR-20a: discriminate CBF, t(15;17), and MLL-rearrangement AMLs" -other hsa-mir-224 "Leukemia, Myeloid, Acute" 18832181 "miR-224: discriminate CBF, t(15;17), and MLL-rearrangement AMLs" -other hsa-mir-382 "Leukemia, Myeloid, Acute" 18832181 "miR-382: discriminate CBF, t(15;17), and MLL-rearrangement AMLs" -other hsa-mir-183 Lung Neoplasms 18840437 miR-183: a potential metastasis-inhibitor -other hsa-mir-125b Psoriasis 18853072 "Recent findings report their involvement in hair follicle morphogenesis (ablation of miRNAs from keratinocytes causes several defects, such as evagination instead of invagination), in psoriasis (skin-specific expression of miR-203 and psoriasisspecific expression of miR-146a, miR-21 and miR-125b in the skin)" -other hsa-mir-146a Psoriasis 18853072 "Recent findings report their involvement in hair follicle morphogenesis (ablation of miRNAs from keratinocytes causes several defects, such as evagination instead of invagination), in psoriasis (skin-specific expression of miR-203 and psoriasisspecific expression of miR-146a, miR-21 and miR-125b in the skin)" -other hsa-mir-203 Psoriasis 18853072 "Recent findings report their involvement in hair follicle morphogenesis (ablation of miRNAs from keratinocytes causes several defects, such as evagination instead of invagination), in psoriasis (skin-specific expression of miR-203 and psoriasisspecific expression of miR-146a, miR-21 and miR-125b in the skin)" -other hsa-mir-21 Psoriasis 18853072 "Recent findings report their involvement in hair follicle morphogenesis (ablation of miRNAs from keratinocytes causes several defects, such as evagination instead of invagination), in psoriasis (skin-specific expression of miR-203 and psoriasisspecific expression of miR-146a, miR-21 and miR-125b in the skin)" -other hsa-mir-106b Neoplasms [unspecific] 18922889 miR-106b: key modulators of TGFbeta signaling -other hsa-mir-17 Neoplasms [unspecific] 18922889 miR-17: key modulators of TGFbeta signaling -other hsa-mir-18a Neoplasms [unspecific] 18922889 miR-18a: key modulators of TGFbeta signaling -other hsa-mir-19a Neoplasms [unspecific] 18922889 miR-19a: key modulators of TGFbeta signaling -other hsa-mir-19b-1 Neoplasms [unspecific] 18922889 miR-19b: key modulators of TGFbeta signaling -other hsa-mir-19b-2 Neoplasms [unspecific] 18922889 miR-19b: key modulators of TGFbeta signaling -other hsa-mir-20a Neoplasms [unspecific] 18922889 miR-20a: key modulators of TGFbeta signaling -other hsa-mir-25 Neoplasms [unspecific] 18922889 miR-25: key modulators of TGFbeta signaling -other hsa-mir-92a-1 Neoplasms [unspecific] 18922889 miR-92a: key modulators of TGFbeta signaling -other hsa-mir-92a-2 Neoplasms [unspecific] 18922889 miR-92a: key modulators of TGFbeta signaling -other hsa-mir-93 Neoplasms [unspecific] 18922889 miR-93: key modulators of TGFbeta signaling -other hsa-mir-141 Neoplasms [unspecific] 18927505 Several recent studies have identified the miR-200 family and miR-205 as key regulators of EMT and enforcers of the epithelial phenotype. -other hsa-mir-200a Neoplasms [unspecific] 18927505 Several recent studies have identified the miR-200 family and miR-205 as key regulators of EMT and enforcers of the epithelial phenotype. -other hsa-mir-200b Neoplasms [unspecific] 18927505 Several recent studies have identified the miR-200 family and miR-205 as key regulators of EMT and enforcers of the epithelial phenotype. -other hsa-mir-200c Neoplasms [unspecific] 18927505 Several recent studies have identified the miR-200 family and miR-205 as key regulators of EMT and enforcers of the epithelial phenotype. -other hsa-mir-205 Neoplasms [unspecific] 18927505 Several recent studies have identified the miR-200 family and miR-205 as key regulators of EMT and enforcers of the epithelial phenotype. -other hsa-mir-429 Neoplasms [unspecific] 18927505 Several recent studies have identified the miR-200 family and miR-205 as key regulators of EMT and enforcers of the epithelial phenotype. -other hsa-mir-21 Breast Neoplasms 18932017 miR-21: High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-beta1 -other hsa-mir-125b-1 "Leukemia, Myeloid, Acute" 18936236 miR-125b-1: Myeloid cell differentiation arrest by miR-125b-1 -other hsa-mir-21 Kaposi Sarcoma 18971265 "Therefore, K15M may contribute to KSHV-mediated tumor metastasis and angiogenesis via regulation of miR-21 and miR-31, which we show here for the first time to be a specific regulator of cell migration." -other hsa-mir-31 Kaposi Sarcoma 18971265 "Therefore, K15M may contribute to KSHV-mediated tumor metastasis and angiogenesis via regulation of miR-21 and miR-31, which we show here for the first time to be a specific regulator of cell migration." -other hsa-mir-125a Medulloblastoma 18973228 miR-125a: promote growth arrest and apoptosis of MB cells -other hsa-mir-9-1 Medulloblastoma 18973228 miR-9: promote growth arrest and apoptosis of MB cells -other hsa-mir-9-2 Medulloblastoma 18973228 miR-9: promote growth arrest and apoptosis of MB cells -other hsa-mir-9-3 Medulloblastoma 18973228 miR-9: promote growth arrest and apoptosis of MB cells -other hsa-mir-106a Gastric Neoplasms 18996190 miR-106a: oncogenic activity -other hsa-mir-34a "Carcinoma, Hepatocellular" 19006648 miR-34a: miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells -other hsa-mir-133a-1 Chronic Heart Failure 19015276 microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart -other hsa-mir-133a-2 Chronic Heart Failure 19015276 microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart -other hsa-mir-122 Hepatitis C Virus Infection 19020517 miR-122: microRNA-122 stimulates translation of hepatitis C virus RNA -other hsa-mir-18a "Carcinoma, Hepatocellular" 19027010 "miR-18a: prevents estrogen receptor-alpha expression, promoting proliferation" -other hsa-mir-453 Breast Neoplasms 19028706 "In contrast, the T allele attenuates the binding of miR-453, which might lead to a reduced miRNA-mediated ESR1 repression, in consequence higher ESR1 protein levels and an increased breast cancer risk." -other hsa-mir-21 Cardiomyopathy 19043405 miR-21: MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts -other hsa-mir-21 Cardiovascular Diseases [unspecific] 19043405 MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts -other hsa-mir-133a Heart Failure 19056878 "It will be interesting to see, if miR-133a is also involved in human heart diseases, especially VSD and dilated cardiomyopathy." -other hsa-mir-21 Neoplasms [unspecific] 19073608 miR-21: coordinately regulate EGFR signaling in multiple human cancer cell types -other hsa-mir-7-1 Neoplasms [unspecific] 19073608 miR-7: coordinately regulate EGFR signaling in multiple human cancer cell types -other hsa-mir-7-2 Neoplasms [unspecific] 19073608 miR-7: coordinately regulate EGFR signaling in multiple human cancer cell types -other hsa-mir-7-3 Neoplasms [unspecific] 19073608 miR-7: coordinately regulate EGFR signaling in multiple human cancer cell types -other hsa-mir-122 Chronic Hepatitis C 19085952 "Moreover, CD56(+) T SN treatment inhibited the expression of HCV-supportive micro RNA (miRNA)-122 and enhanced the levels of anti-HCV miRNA-196a in human hepatocytes." -other hsa-mir-196a Chronic Hepatitis C 19085952 "Moreover, CD56(+) T SN treatment inhibited the expression of HCV-supportive micro RNA (miRNA)-122 and enhanced the levels of anti-HCV miRNA-196a in human hepatocytes." -other hsa-mir-133a-1 Cardiomegaly 19096030 miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling -other hsa-mir-133a-1 Heart Failure 19096030 miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling -other hsa-mir-133a-2 Cardiomegaly 19096030 miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling -other hsa-mir-133a-2 Heart Failure 19096030 miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling -other hsa-mir-133b Cardiomegaly 19096030 miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling -other hsa-mir-133b Heart Failure 19096030 miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling -other hsa-mir-30a Cardiomegaly 19096030 miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling -other hsa-mir-30a Heart Failure 19096030 miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling -other hsa-mir-30b Cardiomegaly 19096030 miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling -other hsa-mir-30b Heart Failure 19096030 miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling -other hsa-mir-29a Acquired Immunodeficiency Syndrome 19102781 miR-29a: Human cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replication -other hsa-mir-520b Neoplasms [unspecific] 19109132 "miR-520b: miR-520b was induced by IFN-gamma, leading to a reduction in MICA surface protein levels" -other hsa-mir-106b Alzheimer Disease 19110058 miR-106b: endogenous regulators of APP expression -other hsa-mir-17 Alzheimer Disease 19110058 miR-17-5p: endogenous regulators of APP expression -other hsa-mir-20a Alzheimer Disease 19110058 miR-20a: endogenous regulators of APP expression -other hsa-mir-200c Pancreatic Neoplasms 19112422 Expression of microRNA was determined with microRNA array. Expression of miR-200c and miR-21 was detected by Northern blotting. -other hsa-mir-195 Schizophrenia 19121517 "Using a postmortem case-control design, the association between BDNF protein, NPY/SST/PV mRNAs, and two BDNF-regulating microRNAs (miR-195 and miR-30a-5p) was determined in samples from the PFC of 20 schizophrenia and 20 control subjects." -other hsa-mir-30a Schizophrenia 19121517 "Using a postmortem case-control design, the association between BDNF protein, NPY/SST/PV mRNAs, and two BDNF-regulating microRNAs (miR-195 and miR-30a-5p) was determined in samples from the PFC of 20 schizophrenia and 20 control subjects." -other hsa-mir-122 Hepatitis C Virus Infection 19122656 miR-122: Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy -other hsa-mir-101-1 Colon Neoplasms 19133256 miR-101: MiR-101 downregulation is involved in cyclooxygenase-2 overexpression -other hsa-mir-101-2 Colon Neoplasms 19133256 miR-101: MiR-101 downregulation is involved in cyclooxygenase-2 overexpression -other hsa-let-7a-1 Pituitary Neoplasms 19136928 let-7a: Overexpression of HMGA2 relates to reduction of the let-7 -other hsa-let-7a-2 Pituitary Neoplasms 19136928 let-7a: Overexpression of HMGA2 relates to reduction of the let-7 -other hsa-let-7a-3 Pituitary Neoplasms 19136928 let-7a: Overexpression of HMGA2 relates to reduction of the let-7 -other hsa-let-7b Pituitary Neoplasms 19136928 let-7b: Overexpression of HMGA2 relates to reduction of the let-7 -other hsa-let-7c Pituitary Neoplasms 19136928 let-7c: Overexpression of HMGA2 relates to reduction of the let-7 -other hsa-let-7d Pituitary Neoplasms 19136928 let-7d: Overexpression of HMGA2 relates to reduction of the let-7 -other hsa-let-7e Pituitary Neoplasms 19136928 let-7e: Overexpression of HMGA2 relates to reduction of the let-7 -other hsa-let-7f-1 Pituitary Neoplasms 19136928 let-7f: Overexpression of HMGA2 relates to reduction of the let-7 -other hsa-let-7f-2 Pituitary Neoplasms 19136928 let-7f: Overexpression of HMGA2 relates to reduction of the let-7 -other hsa-let-7g Pituitary Neoplasms 19136928 let-7g: Overexpression of HMGA2 relates to reduction of the let-7 -other hsa-let-7i Pituitary Neoplasms 19136928 let-7i: Overexpression of HMGA2 relates to reduction of the let-7 -other hsa-mir-199a-1 Hepatitis C Virus Infection 19144437 miR-199a: Regulation of the hepatitis C virus genome replication -other hsa-mir-199a-2 Hepatitis C Virus Infection 19144437 miR-199a: Regulation of the hepatitis C virus genome replication -other hsa-mir-21 Myocardial Infarction 19147588 miR-21: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue -other hsa-mir-223 "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 19148136 miR-223: regulated by Glucocorticoids (GCs) -other hsa-mir-198 Acquired Immunodeficiency Syndrome 19148268 miR-198: miR-198 inhibits HIV-1 gene expression and replication in monocytes -other hsa-mir-27a Gastric Neoplasms 19148490 miR-27a: There was a correlation between mir-27a and lymph node metastasis -other hsa-mir-1 Heart Failure 19149547 "miR-133 and miR-1 are specifically expressed in cardiac and skeletal muscle and control myogenesis, cardiac development, cardiac performance and cardiomyocyte hypertrophy (mainly by tuning transcription factors and other growth-related targets)." -other hsa-mir-133 Heart Failure 19149547 "miR-133 and miR-1 are specifically expressed in cardiac and skeletal muscle and control myogenesis, cardiac development, cardiac performance and cardiomyocyte hypertrophy (mainly by tuning transcription factors and other growth-related targets)." -other hsa-mir-34a "Leukemia, Promyelocytic, Acute" 19151778 miR-34: that enforced expression of miR-342 in APL cells stimulated ATRA-induced differentiation -other hsa-mir-34b "Leukemia, Promyelocytic, Acute" 19151778 miR-34: that enforced expression of miR-342 in APL cells stimulated ATRA-induced differentiation -other hsa-mir-34c "Leukemia, Promyelocytic, Acute" 19151778 miR-34: that enforced expression of miR-342 in APL cells stimulated ATRA-induced differentiation -other hsa-mir-101-1 "Carcinoma, Hepatocellular" 19155302 miR-101: a tumor suppressor -other hsa-mir-101-2 "Carcinoma, Hepatocellular" 19155302 miR-101: a tumor suppressor -other hsa-mir-143 Urinary Bladder Cancer 19157460 miR-143: a tumor suppressor -other hsa-mir-21 Brain Neoplasms 19175699 "Since its identification 3 years ago as the miRNA most commonly and strongly up-regulated in human brain tumour glioblastoma [1], miR-21 has attracted the attention of researchers in various fields" -other hsa-mir-143 Obesity 19188425 Our results provide the first experimental evidence for miR-103 function in adipose biology. -other hsa-mir-196b Leukemia 19188669 miR-196b: MLL normally regulates expression of mir-196b -other hsa-mir-143 Barrett Esophagus 19190970 miR-143: significantly higher -other hsa-mir-219 Nervous System Diseases [unspecific] 19196972 miR-219: MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction -other hsa-mir-17 Medulloblastoma 19196975 miR-17: collaborates with the Sonic Hedgehog pathway -other hsa-mir-18a Medulloblastoma 19196975 miR-18a: collaborates with the Sonic Hedgehog pathway -other hsa-mir-19a Medulloblastoma 19196975 miR-19a: collaborates with the Sonic Hedgehog pathway -other hsa-mir-19b-1 Medulloblastoma 19196975 miR-19b: collaborates with the Sonic Hedgehog pathway -other hsa-mir-19b-2 Medulloblastoma 19196975 miR-19b: collaborates with the Sonic Hedgehog pathway -other hsa-mir-20a Medulloblastoma 19196975 miR-20a: collaborates with the Sonic Hedgehog pathway -other hsa-mir-92a-1 Medulloblastoma 19196975 miR-92a: collaborates with the Sonic Hedgehog pathway -other hsa-mir-92a-2 Medulloblastoma 19196975 miR-92a: collaborates with the Sonic Hedgehog pathway -other hsa-mir-21 Liver Cirrhosis 19203462 miR-21: n/a -other hsa-mir-106a Lung Neoplasms 19209007 "High levels of miR-106a were associated with small-cell lung cancer (p = 0.031), and high levels of miR-19a with advanced NSCLC (p = 0.008)." -other hsa-let-7a-1 Neoplasms [unspecific] 19221491 let-7a: guardians against pluripotency and cancer progression -other hsa-let-7a-2 Neoplasms [unspecific] 19221491 let-7a: guardians against pluripotency and cancer progression -other hsa-let-7a-3 Neoplasms [unspecific] 19221491 let-7a: guardians against pluripotency and cancer progression -other hsa-let-7b Neoplasms [unspecific] 19221491 let-7b: guardians against pluripotency and cancer progression -other hsa-let-7c Neoplasms [unspecific] 19221491 let-7c: guardians against pluripotency and cancer progression -other hsa-let-7d Neoplasms [unspecific] 19221491 let-7d: guardians against pluripotency and cancer progression -other hsa-let-7e Neoplasms [unspecific] 19221491 let-7e: guardians against pluripotency and cancer progression -other hsa-let-7f-1 Neoplasms [unspecific] 19221491 let-7f: guardians against pluripotency and cancer progression -other hsa-let-7f-2 Neoplasms [unspecific] 19221491 let-7f: guardians against pluripotency and cancer progression -other hsa-let-7g Neoplasms [unspecific] 19221491 let-7g: guardians against pluripotency and cancer progression -other hsa-let-7i Neoplasms [unspecific] 19221491 let-7i: guardians against pluripotency and cancer progression -other hsa-mir-200a Neoplasms [unspecific] 19221491 miR-200: guardians against pluripotency and cancer progression -other hsa-mir-200b Neoplasms [unspecific] 19221491 miR-200: guardians against pluripotency and cancer progression -other hsa-mir-200c Neoplasms [unspecific] 19221491 miR-200: guardians against pluripotency and cancer progression -other hsa-mir-126 Lung Neoplasms 19223090 miR-126: inhibit the growth -other hsa-mir-205 Prostate Neoplasms 19244118 miR-205: miR-205 Exerts tumor-suppressive functions in human prostate through down-regulation of protein kinase Cepsilon -other hsa-mir-29a Breast Neoplasms 19247375 "miR-29a: miR-29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasis. Therefore, miRNAs can act as either oncogenes or tumour suppressors, depending on the context" -other hsa-mir-34a Urinary Bladder Cancer 19258450 miR-34a: Oncogenic HPV infection interrupts the expression of tumor-suppressive miR-34a through viral oncoprotein E6 -other hsa-mir-182 Prostate Neoplasms 19267923 miR-182: with high analytical sensitivity and specificity -other hsa-mir-21 Prostate Neoplasms 19267923 miR-21: with high analytical sensitivity and specificity -other hsa-mir-221 Prostate Neoplasms 19267923 miR-221: with high analytical sensitivity and specificity -other hsa-mir-222 Prostate Neoplasms 19267923 miR-222: with high analytical sensitivity and specificity -other hsa-mir-16-1 Neoplasms [unspecific] 19269153 miR-16: can be upregulated by Epigallocatechin gallate -other hsa-mir-16-2 Neoplasms [unspecific] 19269153 miR-16: can be upregulated by Epigallocatechin gallate -other hsa-mir-205 Lung Neoplasms 19273703 miR-205: hsa-miR-205 as a highly specific marker for squamous cell lung carcinoma -other hsa-mir-196b Neutropenia 19278956 miR-196b: regulated by Gfi1 -other hsa-mir-21 Neutropenia 19278956 miR-21: regulated by Gfi1 -other hsa-mir-101-1 Prostate Neoplasms 19285253 miR-101: decrease of miR-101 leads to the overexpression of EZH2 -other hsa-mir-101-2 Prostate Neoplasms 19285253 miR-101: decrease of miR-101 leads to the overexpression of EZH2 -other hsa-mir-196a-2 Lung Neoplasms 19293314 miR-196a-2: Susceptibility of Lung Cancer in Chinese -other hsa-mir-122 "Carcinoma, Hepatocellular" 19296470 miR-122: a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma -other hsa-mir-199b Medulloblastoma 19308264 miR-199b-5p: MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma -other hsa-mir-451a Gastrointestinal Neoplasms 19318487 miR-451: microRNA-451 Regulates Macrophage Migration Inhibitory Factor Proliferation of Gastrointestinal Cancer Cells Production -other hsa-mir-1 Heart Failure 19320780 "The implication of several miRNAs in cardiovascular diseases has been well documented such as miRNA-1 in arrhythmia,miRNA-29 in cardiac fibrosis, miRNA-126 in angiogenesis and miRNA-133 in cardiac hypertrophy." -other hsa-mir-126 Heart Failure 19320780 "The implication of several miRNAs in cardiovascular diseases has been well documented such as miRNA-1 in arrhythmia,miRNA-29 in cardiac fibrosis, miRNA-126 in angiogenesis and miRNA-133 in cardiac hypertrophy." -other hsa-mir-133 Heart Failure 19320780 "The implication of several miRNAs in cardiovascular diseases has been well documented such as miRNA-1 in arrhythmia,miRNA-29 in cardiac fibrosis, miRNA-126 in angiogenesis and miRNA-133 in cardiac hypertrophy." -other hsa-mir-29 Heart Failure 19320780 "The implication of several miRNAs in cardiovascular diseases has been well documented such as miRNA-1 in arrhythmia,miRNA-29 in cardiac fibrosis, miRNA-126 in angiogenesis and miRNA-133 in cardiac hypertrophy." -other hsa-let-7a-1 Pancreatic Neoplasms 19323605 Let-7a: inhibits in vitro cell proliferation but fails to alter tumor progression -other hsa-let-7a-2 Pancreatic Neoplasms 19323605 Let-7a: inhibits in vitro cell proliferation but fails to alter tumor progression -other hsa-let-7a-3 Pancreatic Neoplasms 19323605 Let-7a: inhibits in vitro cell proliferation but fails to alter tumor progression -other hsa-let-7b Pancreatic Neoplasms 19323605 Let-7b: inhibits in vitro cell proliferation but fails to alter tumor progression -other hsa-let-7c Pancreatic Neoplasms 19323605 Let-7c: inhibits in vitro cell proliferation but fails to alter tumor progression -other hsa-let-7d Pancreatic Neoplasms 19323605 Let-7d: inhibits in vitro cell proliferation but fails to alter tumor progression -other hsa-let-7e Pancreatic Neoplasms 19323605 Let-7e: inhibits in vitro cell proliferation but fails to alter tumor progression -other hsa-let-7f-1 Pancreatic Neoplasms 19323605 Let-7f: inhibits in vitro cell proliferation but fails to alter tumor progression -other hsa-let-7f-2 Pancreatic Neoplasms 19323605 Let-7f: inhibits in vitro cell proliferation but fails to alter tumor progression -other hsa-let-7g Pancreatic Neoplasms 19323605 Let-7g: inhibits in vitro cell proliferation but fails to alter tumor progression -other hsa-let-7i Pancreatic Neoplasms 19323605 Let-7i: inhibits in vitro cell proliferation but fails to alter tumor progression -other hsa-mir-146a Lupus Vulgaris 19333922 miR-146a: miR-146a contributes to abnormal activation of the type i interferon pathway in human lupus by targeting the key signaling proteins -other hsa-mir-221 Hyperglycemia 19351599 miR-221: induced expression -other hsa-mir-221 Vascular Disease [unspecific] 19351599 MicroRNA-221 regulates high glucose-induced endothelial dysfunction -other hsa-let-7c Prostate Neoplasms 19372056 "We hypothesize that miR-let7c, miR-100, and miR-218 may be involved in the process of metastasization of PC, and their role as controllers of the expression of RAS, c-myc, Laminin 5 ¦Â3, THAP2, SMARCA5, and BAZ2A should be matter of additional studies." -other hsa-mir-100 Prostate Neoplasms 19372056 "We hypothesize that miR-let7c, miR-100, and miR-218 may be involved in the process of metastasization of PC, and their role as controllers of the expression of RAS, c-myc, Laminin 5 ¦Â3, THAP2, SMARCA5, and BAZ2A should be matter of additional studies." -other hsa-mir-218 Prostate Neoplasms 19372056 "We hypothesize that miR-let7c, miR-100, and miR-218 may be involved in the process of metastasization of PC, and their role as controllers of the expression of RAS, c-myc, Laminin 5 ¦Â3, THAP2, SMARCA5, and BAZ2A should be matter of additional studies." -other hsa-mir-34a Neuroblastoma 19373781 "Neuroblastoma (NB) is the most common extracranial solid tumor in children below the age of 5 years. miR-34a, located in chromosome band 1p36, has been recently implicated as a tumor suppressor gene in NB." -other hsa-mir-124a Rheumatoid Arthritis 19404929 The results of this study suggest that miR-124a is a key miRNA in the posttranscriptional regulatory mechanisms of RA synoviocytes. -other hsa-mir-196a "Carcinoma, Rectal" 19418581 miR-196a exerts a pro-oncogenic influence in colorectal cancer. -other hsa-mir-143 Gastrointestinal Neoplasms 19439999 "Taken together, these findings suggest that miR-143 and miR-145 act as anti-oncomirs common to gastrointestinal tumors." -other hsa-mir-145 Gastrointestinal Neoplasms 19439999 "Taken together, these findings suggest that miR-143 and miR-145 act as anti-oncomirs common to gastrointestinal tumors." -other hsa-mir-34a Neuroblastoma 19461653 "In this review, the evidence for a role of miR-34a and miR-34b/c in the apoptotic response of normal and tumor cells is surveyed." -other hsa-mir-224 Pancreatic Neoplasms 19475450 miR-224 and miR-486 are associated with the progression of pancreatic ductal adenocarcinomas -other hsa-mir-486 Pancreatic Neoplasms 19475450 miR-224 and miR-486 are associated with the progression of pancreatic ductal adenocarcinomas -other hsa-let-7a Ovarian Neoplasms 19477633 Our study also suggests that lin-28B may promote ovarian cancer progression and serve as an unfavourable prognostic marker for the disease. -other hsa-mir-129 Bladder Neoplasms 19487295 "We identified several miRNAs with prognostic potential for predicting disease progression (e.g., miR-129, miR-133b, and miR-518c*)." -other hsa-mir-133b Bladder Neoplasms 19487295 "We identified several miRNAs with prognostic potential for predicting disease progression (e.g., miR-129, miR-133b, and miR-518c*)." -other hsa-mir-26a Glioma 19487573 The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo. -other hsa-mir-106a Mesothelioma 19502386 "The expression of miR-17-5p, miR-21, miR-29a, miR-30c, miR-30e-5p, miR-106a, and miR-143 was significantly associated with the histopathological subtype" -other hsa-mir-143 Mesothelioma 19502386 "The expression of miR-17-5p, miR-21, miR-29a, miR-30c, miR-30e-5p, miR-106a, and miR-143 was significantly associated with the histopathological subtype" -other hsa-mir-17 Mesothelioma 19502386 "The expression of miR-17-5p, miR-21, miR-29a, miR-30c, miR-30e-5p, miR-106a, and miR-143 was significantly associated with the histopathological subtype" -other hsa-mir-21 Mesothelioma 19502386 "The expression of miR-17-5p, miR-21, miR-29a, miR-30c, miR-30e-5p, miR-106a, and miR-143 was significantly associated with the histopathological subtype" -other hsa-mir-29a Mesothelioma 19502386 "The expression of miR-17-5p, miR-21, miR-29a, miR-30c, miR-30e-5p, miR-106a, and miR-143 was significantly associated with the histopathological subtype" -other hsa-mir-30c-1 Mesothelioma 19502386 "The expression of miR-17-5p, miR-21, miR-29a, miR-30c, miR-30e-5p, miR-106a, and miR-143 was significantly associated with the histopathological subtype" -other hsa-mir-30c-2 Mesothelioma 19502386 "The expression of miR-17-5p, miR-21, miR-29a, miR-30c, miR-30e-5p, miR-106a, and miR-143 was significantly associated with the histopathological subtype" -other hsa-mir-30e Mesothelioma 19502386 "The expression of miR-17-5p, miR-21, miR-29a, miR-30c, miR-30e-5p, miR-106a, and miR-143 was significantly associated with the histopathological subtype" -other hsa-mir-1 Heart Failure 19519553 MiR-1 influences susceptibility to cardiac arrhythmias after myocardial infarction. -other hsa-mir-208 Heart Failure 19519553 MiR-208 is involved in the shift toward a fetal gene expression pattern in contractile proteins in heart failure. -other hsa-mir-21 Heart Failure 19519553 MiR-29 is involved in fibrotic reaction after myocardial infarction while miR-21 may exert a fundamental role in post-angioplasty restenosis. -other hsa-mir-222 Glioblastoma 19520829 "Immunohistochemical and in situ hybridization analyses of 30 primary glioblastoma tissues demonstrated that expression of Dicer, miR-222, or miR-339 was inversely associated with ICAM-1 expression." -other hsa-mir-339 Glioblastoma 19520829 "Immunohistochemical and in situ hybridization analyses of 30 primary glioblastoma tissues demonstrated that expression of Dicer, miR-222, or miR-339 was inversely associated with ICAM-1 expression." -other hsa-mir-184 Neoplasms [unspecific] 19546886 "laryngeal carcinoma, upregulated; control of the G1-S phase transition;regulate BTG2, a cell cycle gene" -other hsa-mir-15a "Carcinoma, Lung, Non-Small-Cell" 19549910 miR-15a and miR-16 are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non-small cell lung cancer. -other hsa-mir-16 "Carcinoma, Lung, Non-Small-Cell" 19549910 miR-15a and miR-16 are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non-small cell lung cancer. -other hsa-mir-29a Breast Neoplasms 19567675 "potentially oncogenic role in breast tumorigenesis; significantly associated with decreased breast cancer risk; mutant precursors of miR-196a-2 into breast cancer cells led to less efficient processing of the miRNA precursor to its mature form as well as diminished capacity to regulate target genes, further showed that cell cycle response to mutagen challenge was significantly enhanced;" -other hsa-mir-23a Hepatitis C Virus Infection 19578061 "virus specific, miR-122-sensitive double-helical switch element in the 5' region--a new mechanism of action of micro-RNAs" -other hsa-mir-661 "Squamous Cell Carcinoma, Lung" 19584273 miR-146b alone have the strongest prediction accuracy for stratifying prognostic groups; -other hsa-let-7 Infection [unspecific] 19592657 "Our data suggest that miR-98 and let-7 confer cholangiocyte expression of CIS in response to microbial challenge, a process that may be relevant to the regulation of TLR-mediated epithelial innate immune response." -other hsa-mir-98 Infection [unspecific] 19592657 "Our data suggest that miR-98 and let-7 confer cholangiocyte expression of CIS in response to microbial challenge, a process that may be relevant to the regulation of TLR-mediated epithelial innate immune response." -other hsa-mir-141 Neoplasms [unspecific] 19593777 association with cancer progression -other hsa-mir-200b Neoplasms [unspecific] 19593777 association with cancer progression -other hsa-mir-200c Neoplasms [unspecific] 19593777 association with cancer progression -other hsa-mir-205 Neoplasms [unspecific] 19593777 association with cancer progression -other hsa-mir-21 Neoplasms [unspecific] 19593777 association with cancer progression -other hsa-mir-30a Neoplasms [unspecific] 19593777 association with cancer progression -other hsa-mir-30e Neoplasms [unspecific] 19593777 association with cancer progression -other hsa-mir-21 Prostate Neoplasms 19597470 acts as tumor suppressor and induces apoptosis of tumor cells through E2F1-mediated suppression of Akt phosphorylation -other hsa-mir-330 Prostate Neoplasms 19597470 MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation -other hsa-mir-122 Gastrointestinal Neoplasms 19607815 The down-regulation of miR-122a mediated by aberrant APC/beta-catenin signaling is important to the pathogenesis of gastrointestinal cancers. -other hsa-mir-125a Myelodysplastic Syndromes 19615744 Significant inverse correlation of microRNA-150/MYB and microRNA-222/p27 in myelodysplastic syndrome -other hsa-mir-221 Myelodysplastic Syndromes 19615744 Significant inverse correlation of microRNA-150/MYB and microRNA-222/p27 in myelodysplastic syndrome -other hsa-mir-222 Myelodysplastic Syndromes 19615744 Significant inverse correlation of microRNA-150/MYB and microRNA-222/p27 in myelodysplastic syndrome -other hsa-mir-599 Multiple Sclerosis 19617918 relevant at the time of relapse -other hsa-mir-96 Multiple Sclerosis 19617918 relevant at the time of relapse -other hsa-mir-206 Rhabdomyosarcoma 19620785 miR-1 was barely detectable in primary RMS -other hsa-mir-34c Rhabdomyosarcoma 19620785 "The muscle-specific microRNA miR-206, blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation" -other hsa-mir-188 Cardiovascular Diseases [unspecific] 19669742 These findings suggest that dicer and miRNAs especially miR-188 are involved in Hcy-induced cardiac remodeling -other hsa-mir-93 Urinary Bladder Cancer 19671845 control the EMT process and sensitivity to EGFR therapy -other hsa-mir-18b Breast Neoplasms 19684618 inhibit Eralpha signaling -other hsa-mir-193b Breast Neoplasms 19684618 inhibit Eralpha signaling -other hsa-mir-206 Breast Neoplasms 19684618 inhibit Eralpha signaling -other hsa-mir-302c Breast Neoplasms 19684618 inhibit Eralpha signaling -other hsa-mir-185 Lung Neoplasms 19688090 cell cycle arrest -other hsa-mir-18a Lung Neoplasms 19688090 cell cycle arrest -other hsa-mir-125a Muscular Dystrophy 19690046 regulation of §Ø©ãmyosin heavy chain gene -other hsa-mir-208b Muscular Dystrophy 19690046 regulation of §Ø©ãmyosin heavy chain gene -other hsa-mir-107 "Leukemia, Lymphocytic, Chronic, B-Cell" 19692702 "regulation of PLAG1 by miR-181a, miR-181b, miR-107, and miR-424" -other hsa-mir-182 Pain 19699278 "association with chronic neuropathic pain, mechanical hypersensitivity" -other hsa-mir-183 Pain 19699278 "association with chronic neuropathic pain, mechanical hypersensitivity" -other hsa-mir-34a Pain 19699278 "association with chronic neuropathic pain, mechanical hypersensitivity" -other hsa-mir-96 Pain 19699278 "association with chronic neuropathic pain, mechanical hypersensitivity" -other hsa-mir-155 Gastric Neoplasms 19702585 possible role in the intimate relationship -other hsa-mir-15a Myelodysplastic Syndromes 19702585 differentially expressed between low-risk and high-risk -other hsa-mir-21 Gastric Neoplasms 19702585 possible role in the intimate relationship -other hsa-mir-221 Gastric Neoplasms 19702585 possible role in the intimate relationship -other hsa-mir-222 Gastric Neoplasms 19702585 possible role in the intimate relationship -other hsa-mir-27a Gastric Neoplasms 19702585 possible role in the intimate relationship -other hsa-mir-125a Lung Neoplasms 19702827 "Taken together, our results provide compelling evidence that miR-125a-5p, an epidermal growth factor-signaling-regulated miRNA, may function as a metastatic suppressor." -other hsa-mir-200a Meningioma 19703647 Down-regulation Promotes Tumor Growth by reducing E-cadherin and Activating the Wnt/{beta} catenin Signaling Pathway -other hsa-mir-200a Meningioma 19703993 "This reveals a previously unrecognized signaling cascade involved in meningioma tumor development and highlights a novel molecular interaction between miR-200a and Wnt signaling, thereby providing insights into novel therapies for meningiomas." -other hsa-mir-128-1 Neuroblastoma 19713529 reduce cell motility and invasiveness -other hsa-mir-128-2 Neuroblastoma 19713529 reduce cell motility and invasiveness -other hsa-mir-34a Pancreatic Neoplasms 19714243 inhibits tumor-initiating cells. -other hsa-mir-34b Pancreatic Neoplasms 19714243 inhibits tumor-initiating cells. -other hsa-mir-34c Pancreatic Neoplasms 19714243 inhibits tumor-initiating cells. -other hsa-mir-146a "Leukemia, Lymphocytic, Chronic, B-Cell" 19717645 correlated with assessment of biological impact on Chronic Lymphocytic Leukemia -other hsa-mir-146b "Leukemia, Lymphocytic, Chronic, B-Cell" 19717645 correlated with assessment of biological impact on Chronic Lymphocytic Leukemia -other hsa-mir-148a "Leukemia, Lymphocytic, Chronic, B-Cell" 19717645 correlated with assessment of biological impact on Chronic Lymphocytic Leukemia -other hsa-mir-151a "Leukemia, Lymphocytic, Chronic, B-Cell" 19717645 correlated with assessment of biological impact on Chronic Lymphocytic Leukemia -other hsa-mir-155 "Leukemia, Lymphocytic, Chronic, B-Cell" 19717645 correlated with assessment of biological impact on Chronic Lymphocytic Leukemia -other hsa-mir-29b-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 19717645 correlated with assessment of biological impact on Chronic Lymphocytic Leukemia -other hsa-mir-29c "Leukemia, Lymphocytic, Chronic, B-Cell" 19717645 correlated with assessment of biological impact on Chronic Lymphocytic Leukemia -other hsa-mir-34a "Leukemia, Lymphocytic, Chronic, B-Cell" 19717645 correlated with assessment of biological impact on Chronic Lymphocytic Leukemia -other hsa-mir-640 "Leukemia, Lymphocytic, Chronic, B-Cell" 19717645 correlated with assessment of biological impact on Chronic Lymphocytic Leukemia -other hsa-mir-155 Intracerebral Hemorrhage 19724284 correlate -other hsa-mir-298 Intracerebral Hemorrhage 19724284 correlate -other hsa-mir-362 Intracerebral Hemorrhage 19724284 correlate -other hsa-mir-21 Pancreatic Adenocarcinoma 19730150 "Antisense Inhibition of microRNA-21 or -221 Arrests Cell Cycle, Induces Apoptosis, and Sensitizes the Effects of Gemcitabine in Pancreatic Adenocarcinoma." -other hsa-mir-221 Pancreatic Adenocarcinoma 19730150 "Antisense Inhibition of microRNA-21 or -221 Arrests Cell Cycle, Induces Apoptosis, and Sensitizes the Effects of Gemcitabine in Pancreatic Adenocarcinoma." -other hsa-mir-145 Breast Neoplasms 19730444 miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha in human breast cancer cells. -other hsa-mir-140 Colon Neoplasms 19734943 high-throughput microRNA (miRNA) expression analysis revealed that the expression of miR-140 was associated with chemosensitivity in osteosarcoma tumor xenografts -other hsa-mir-140 Osteosarcoma 19734943 high-throughput microRNA (miRNA) expression analysis revealed that the expression of miR-140 was associated with chemosensitivity in osteosarcoma tumor xenografts -other hsa-mir-34a Lung Neoplasms 19736307 relevant to the diagnosis -other hsa-mir-500a "Carcinoma, Hepatocellular" 19737067 oncofetal miRNA relevant to the diagnosis -other hsa-mir-21 "Adenocarcinoma, Colon" 19737943 predictors of prognosis -other hsa-mir-10a Pancreatic Neoplasms 19747919 Inhibition of miR-10a expression (with retinoic acid receptor antagonists) or function (with specific inhibitors) is a promising starting point for antimetastatic therapies. -other hsa-mir-126 "Leukemia, Lymphoblastic" 19760605 "ANOVA highlighted a set of six miRNAs-namely miR-425-5p, miR-191, miR-146b, miR-128, miR-629, and miR-126-that can discriminate B-lineage ALL subgroups harboring specific molecular lesions." -other hsa-mir-128 "Leukemia, Lymphoblastic" 19760605 "ANOVA highlighted a set of six miRNAs-namely miR-425-5p, miR-191, miR-146b, miR-128, miR-629, and miR-126-that can discriminate B-lineage ALL subgroups harboring specific molecular lesions." -other hsa-mir-146b "Leukemia, Lymphoblastic" 19760605 "ANOVA highlighted a set of six miRNAs-namely miR-425-5p, miR-191, miR-146b, miR-128, miR-629, and miR-126-that can discriminate B-lineage ALL subgroups harboring specific molecular lesions." -other hsa-mir-191 "Leukemia, Lymphoblastic" 19760605 "ANOVA highlighted a set of six miRNAs-namely miR-425-5p, miR-191, miR-146b, miR-128, miR-629, and miR-126-that can discriminate B-lineage ALL subgroups harboring specific molecular lesions." -other hsa-mir-425 "Leukemia, Lymphoblastic" 19760605 "ANOVA highlighted a set of six miRNAs-namely miR-425-5p, miR-191, miR-146b, miR-128, miR-629, and miR-126-that can discriminate B-lineage ALL subgroups harboring specific molecular lesions." -other hsa-mir-629 "Leukemia, Lymphoblastic" 19760605 "ANOVA highlighted a set of six miRNAs-namely miR-425-5p, miR-191, miR-146b, miR-128, miR-629, and miR-126-that can discriminate B-lineage ALL subgroups harboring specific molecular lesions." -other hsa-mir-17 Prostate Neoplasms 19771525 "MicroRNA-17-3p is a prostate tumor suppressor in vitro and in vivo, and is decreased in high grade prostate tumors analyzed by laser capture microdissection." -other hsa-mir-210 Pancreatic Neoplasms 19782034 "When human head and neck or pancreatic tumor cells ectopically expressing mir-210 were implanted into immunodeficient mice, mir-210 repressed initiation of tumor growth." -other hsa-let-7a Laryngeal Neoplasms 19787239 "Thus, we propose that let-7a may be a tumor suppressor in laryngeal cancer by inhibiting cell growth, inducing cell apoptosis and downregulating the oncogenes expression." -other hsa-mir-375 Diabetes Mellitus 19800254 "Recent studies, for example, implicate miR-375 in pancreatic islet cell viability and function, and removal or overexpression of miR-375 profoundly affects glucose metabolism. " -other hsa-mir-421 Gastrointestinal Neoplasms 19802518 miR-421 may involve in the early stage of stomach carcinogenesis and could be used as an efficient diagnostic biomarker. -other hsa-mir-106b Alopecia 19821055 "mir-106b:four microRNAs (miR-221, miR-125b, miR-106b and miR-410) that could participate in pathogenesis of MPB" -other hsa-mir-125b-1 Alopecia 19821055 "miR-125b:four microRNAs (miR-221, miR-125b, miR-106b and miR-410) that could participate in pathogenesis of MPB" -other hsa-mir-125b-2 Alopecia 19821055 "miR-125b:four microRNAs (miR-221, miR-125b, miR-106b and miR-410) that could participate in pathogenesis of MPB" -other hsa-mir-221 Alopecia 19821055 "miR-221:four microRNAs (miR-221, miR-125b, miR-106b and miR-410) that could participate in pathogenesis of MPB" -other hsa-mir-410 Alopecia 19821055 "miR-410:four microRNAs (miR-221, miR-125b, miR-106b and miR-410) that could participate in pathogenesis of MPB" -other hsa-mir-141 Colorectal Carcinoma 19830559 miR-141:miR-141 regulates SIP1 to inhibit migration and invasion of CRC cells -other hsa-mir-326 Multiple Sclerosis 19838199 miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis -other hsa-mir-200a Breast Neoplasms 19839049 miR-200a:microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells -other hsa-mir-200b Breast Neoplasms 19839049 miR-200b:microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells -other hsa-mir-200c Breast Neoplasms 19839049 miR-200c:microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells -other hsa-mir-143 Colorectal Carcinoma 19843160 "Collectively, the data obtained in the present study suggest anti-proliferative, chemosensitizer and putative pro-apoptotic roles for miR-143 in colon cancer." -other hsa-mir-143 Colorectal Carcinoma 19843336 In vitro functional studies indicated that miR-143 and miR-145 appear to function in opposing manners to either inhibit or augment cell proliferation in a metastatic CRC model. -other hsa-mir-145 Colorectal Carcinoma 19843336 In vitro functional studies indicated that miR-143 and miR-145 appear to function in opposing manners to either inhibit or augment cell proliferation in a metastatic CRC model. -other hsa-mir-130a Adrenal Cortex Neoplasms 19849700 miR-130a:miR-130a and miR-382 as putative diagnostic MMAD markers -other hsa-mir-382 Adrenal Cortex Neoplasms 19849700 miR-382:miR-130a and miR-382 as putative diagnostic MMAD markers -other hsa-mir-144 Schizophrenia 19849891 "The most promising miRNAs so far identified include miR-181, miR-346 and miR-195 in schizophrenia and miR-34a and miR-144 in bipolar disorder." -other hsa-mir-181 Schizophrenia 19849891 "The most promising miRNAs so far identified include miR-181, miR-346 and miR-195 in schizophrenia and miR-34a and miR-144 in bipolar disorder." -other hsa-mir-195 Schizophrenia 19849891 "The most promising miRNAs so far identified include miR-181, miR-346 and miR-195 in schizophrenia and miR-34a and miR-144 in bipolar disorder." -other hsa-mir-346 Schizophrenia 19849891 "The most promising miRNAs so far identified include miR-181, miR-346 and miR-195 in schizophrenia and miR-34a and miR-144 in bipolar disorder." -other hsa-mir-34a Schizophrenia 19849891 "The most promising miRNAs so far identified include miR-181, miR-346 and miR-195 in schizophrenia and miR-34a and miR-144 in bipolar disorder." -other hsa-mir-500 "Carcinoma, Hepatocellular" 19863192 "Our findings reveal that diverse changes of miRNAs occur during liver development and, one of these, miR-500 is an oncofetal miRNA relevant to the diagnosis of human HCC." -other hsa-mir-15a "Leukemia, Myeloid, Acute" 19883312 miR-15a in BM ( p = 0.034) and miR-16 in PB ( p = 0.005) were differentially expressed between low-risk and high-risk groups -other hsa-mir-222 "Leukemia, Myeloid, Acute" 19883312 miR-222 ( p = 0.0023) and miR-181a ( p = 0.014) expression was higher in AML than in MDS -other hsa-mir-326 Breast Neoplasms 19883630 Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1 -other hsa-mir-17 Neoplasms [unspecific] 19887902 miR-17-5p has initially been linked to tumorigenesis -other hsa-mir-18a Neoplasms [unspecific] 19887902 has initially been linked to tumorigenesis -other hsa-mir-19a Neoplasms [unspecific] 19887902 has initially been linked to tumorigenesis -other hsa-mir-20a Neoplasms [unspecific] 19887902 has initially been linked to tumorigenesis -other hsa-mir-138-1 Leukemia 19896708 miR-138:miR-138 might reverse multidrug resistance of leukemia cells -other hsa-mir-138-2 Leukemia 19896708 miR-138:miR-138 might reverse multidrug resistance of leukemia cells -other hsa-mir-145 Myelodysplastic Syndromes 19898489 "5q- syndrome deleted,Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype" -other hsa-mir-146a Myelodysplastic Syndromes 19898489 "5q- syndrome deleted,Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype" -other hsa-mir-17 Severe Acute Respiratory Syndrome Virus Infection 19915717 "Upregulated BASC miRNAs-17*, -574-5p, and -214 are co-opted by SARS-CoV to suppress its own replication and evade immune elimination" -other hsa-mir-214 Severe Acute Respiratory Syndrome Virus Infection 19915717 "Upregulated BASC miRNAs-17*, -574-5p, and -214 are co-opted by SARS-CoV to suppress its own replication and evade immune elimination" -other hsa-mir-574 Severe Acute Respiratory Syndrome Virus Infection 19915717 "Upregulated BASC miRNAs-17*, -574-5p, and -214 are co-opted by SARS-CoV to suppress its own replication and evade immune elimination" -other hsa-mir-126 Vascular Disease [unspecific] 19917099 "miR-126, miR-24 and miR-23a are selectively expressed in microvascular endothelial cells in vivo" -other hsa-mir-145 Vascular Disease [unspecific] 19917099 elevated levels of miR-145 reduced migration of microvascular cells in response to growth factor gradients in vitro -other hsa-mir-23a Vascular Disease [unspecific] 19917099 "miR-126, miR-24 and miR-23a are selectively expressed in microvascular endothelial cells in vivo" -other hsa-mir-25 Endomyocardial Fibrosis 19919989 both miR-25 and miR-29a were sufficient to decrease collagen gene expression -other hsa-mir-29a Endomyocardial Fibrosis 19919989 both miR-25 and miR-29a were sufficient to decrease collagen gene expression -other hsa-mir-27a Breast Neoplasms 19921425 "We hypothesize that the G-variant of rs895819 might impair the maturation of the oncogenic miR-27a and thus, is associated with familial breast cancer risk." -other hsa-mir-34a Lung Neoplasms 19921694 miR-34a:MicroRNA-34a is an important component of PRIMA-1-induced apoptotic network in human lung cancer cells -other hsa-mir-17 Lymphoma 19933089 "miR-17-5p can induce tumorigenesis, such as lymphoma and vascularized tumor as an oncogene" -other hsa-mir-18a Lymphoma 19933089 "it can induce tumorigenesis, such as lymphoma and vascularized tumor as an oncogene" -other hsa-mir-19a Lymphoma 19933089 "it can induce tumorigenesis, such as lymphoma and vascularized tumor as an oncogene" -other hsa-mir-20a Lymphoma 19933089 "it can induce tumorigenesis, such as lymphoma and vascularized tumor as an oncogene" -other hsa-mir-21 Glioma 19934272 the results of our study show that the downregulation of miR-21 contributes to the antitumor effects of IFN-beta and that miR-21 expression is negatively regulated by STAT3 activation. These results highlight the importance of understanding the transcriptional regulation of the miRNAs involved in oncogenesis. -other hsa-mir-140 Osteoarthritis 19948051 "We investigated whether two highly predicted microRNAs (miRNAs), miR-140 and miR-27a, regulate these two genes in human OA chondrocytes." -other hsa-mir-27a Osteoarthritis 19948051 "We investigated whether two highly predicted microRNAs (miRNAs), miR-140 and miR-27a, regulate these two genes in human OA chondrocytes." -other hsa-let-7g Gastric Neoplasms 19948396 "different miRNAs have been found to predict sensitivity to anticancer treatment: miR-30c, miR-130a and miR-335 are downregulated in various chemoresistant cell lines, hsa-Let-7g and hsa-miR-181b are strongly associated with response to 5-fluorouracil-based antimetabolite S-1" -other hsa-mir-181b Gastric Neoplasms 19948396 "different miRNAs have been found to predict sensitivity to anticancer treatment: miR-30c, miR-130a and miR-335 are downregulated in various chemoresistant cell lines, hsa-Let-7g and hsa-miR-181b are strongly associated with response to 5-fluorouracil-based antimetabolite S-1" -other hsa-mir-126 Gastrointestinal Neoplasms 19951901 "We have identified a seven-miRNA signature (miR-10b, miR-21, miR-223, miR-338, let-7a, miR-30a-5p, miR-126) for overall survival (p=0.0009) and relapse-free survival (p=0.0005) of gastric cancer patients. " -other hsa-mir-29a Irritable Bowel Syndrome 19951903 miR-29a:MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome -other hsa-mir-27a "Squamous Cell Carcinoma, Esophageal" 19960259 miR-27a:Down-regulation of miR-27a might reverse multidrug resistance of esophageal squamous cell carcinoma -other hsa-mir-146a Immune System Disease [unspecific] 19965651 "Our results demonstrate that several signaling pathways, other than inflammation, are influenced by miR-146a. In particular, we provide experimental evidence that miR-146a modulates activation-induced cell death (AICD), acting as an antiapoptotic factor, and that Fas-associated death domain (FADD) is a target of miR-146a." -other hsa-mir-122 Hepatitis C Virus Infection 19965718 a locked nucleic acid (LNA)-modified oligonucleotide (SPC3649) complementary to miR-122 leads to long-lasting suppression of HCV viremia -other hsa-mir-145 Breast Neoplasms 19996288 "Taken together, these results suggest that as a tumor suppressor, miR-145 inhibits not only tumor growth but also cell invasion and metastasis." -other hsa-mir-145 Prostate Neoplasms 19996289 miR-145 and miR-331-3p are predicted to target 3 of the 20 hub genes -other hsa-mir-331 Prostate Neoplasms 19996289 miR-145 and miR-331-3p are predicted to target 3 of the 20 hub genes -other hsa-mir-126 Atherosclerosis 19996457 Administration of apoptotic bodies or miR-126 limited atherosclerosis -other hsa-mir-21 Cystic Fibrosis 19997496 "mir-125b-1, mir-21, mir-30b, and mir-23b-27b-24-1 cluster genes were transactivated through promoter binding of the NF-kappaB p65 subunit following C. parvum infection" -other hsa-mir-23b Cystic Fibrosis 19997496 "mir-125b-1, mir-21, mir-30b, and mir-23b-27b-24-1 cluster genes were transactivated through promoter binding of the NF-kappaB p65 subunit following C. parvum infection" -other hsa-mir-27b Cystic Fibrosis 19997496 "mir-125b-1, mir-21, mir-30b, and mir-23b-27b-24-1 cluster genes were transactivated through promoter binding of the NF-kappaB p65 subunit following C. parvum infection" -other hsa-mir-30b Cystic Fibrosis 19997496 "mir-125b-1, mir-21, mir-30b, and mir-23b-27b-24-1 cluster genes were transactivated through promoter binding of the NF-kappaB p65 subunit following C. parvum infection" -other hsa-mir-31 Intestinal Schistosomiasis 19997615 "some nucleotides at many positions of Schistosoma miRNAs, such as miR-8, let-7, miR-10, miR-31, miR-92, miR-124, and miR-125, are indeed significantly distinct from other bilaterian orthologs" -other hsa-let-7a-1 Retinoblastoma 20004941 "Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation,invasion, and proliferation associated with let-7 down-regulation in retinoblastomas." -other hsa-let-7a-2 Retinoblastoma 20004941 "Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation,invasion, and proliferation associated with let-7 down-regulation in retinoblastomas." -other hsa-let-7a-3 Retinoblastoma 20004941 "Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation,invasion, and proliferation associated with let-7 down-regulation in retinoblastomas." -other hsa-let-7b Retinoblastoma 20004941 "Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation,invasion, and proliferation associated with let-7 down-regulation in retinoblastomas." -other hsa-let-7c Retinoblastoma 20004941 "Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation,invasion, and proliferation associated with let-7 down-regulation in retinoblastomas." -other hsa-let-7d Retinoblastoma 20004941 "Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation,invasion, and proliferation associated with let-7 down-regulation in retinoblastomas." -other hsa-let-7e Retinoblastoma 20004941 "Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation,invasion, and proliferation associated with let-7 down-regulation in retinoblastomas." -other hsa-let-7f-1 Retinoblastoma 20004941 "Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation,invasion, and proliferation associated with let-7 down-regulation in retinoblastomas." -other hsa-let-7f-2 Retinoblastoma 20004941 "Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation,invasion, and proliferation associated with let-7 down-regulation in retinoblastomas." -other hsa-let-7g Retinoblastoma 20004941 "Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation,invasion, and proliferation associated with let-7 down-regulation in retinoblastomas." -other hsa-let-7i Retinoblastoma 20004941 "Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation,invasion, and proliferation associated with let-7 down-regulation in retinoblastomas." -other hsa-mir-132 Inflammation 20005135 MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase -other hsa-mir-1181 Hepatitis C Virus Infection 20006370 "miR-24, miR-149, miR-638 and miR-1181 were identified to be involved in HCV entry, replication and propagation" -other hsa-mir-149 Hepatitis C Virus Infection 20006370 "miR-24, miR-149, miR-638 and miR-1181 were identified to be involved in HCV entry, replication and propagation" -other hsa-mir-24-1 Hepatitis C Virus Infection 20006370 "miR-24, miR-149, miR-638 and miR-1181 were identified to be involved in HCV entry, replication and propagation" -other hsa-mir-24-2 Hepatitis C Virus Infection 20006370 "miR-24, miR-149, miR-638 and miR-1181 were identified to be involved in HCV entry, replication and propagation" -other hsa-mir-638 Hepatitis C Virus Infection 20006370 "miR-24, miR-149, miR-638 and miR-1181 were identified to be involved in HCV entry, replication and propagation" -other hsa-mir-206 Amyotrophic Lateral Sclerosis 20007902 MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice -other hsa-mir-19a Neoplasms [unspecific] 20008935 miR-19 is a key oncogenic component of mir-17-92 -other hsa-mir-19b-1 Neoplasms [unspecific] 20008935 miR-19 is a key oncogenic component of mir-17-92 -other hsa-mir-19b-2 Neoplasms [unspecific] 20008935 miR-19 is a key oncogenic component of mir-17-92 -other hsa-mir-146a Chlamydial Infection 20011700 microRNA-146a is a negative regulator of Tolllike receptor (TLR) signaling -other hsa-mir-133a-1 "Cardiomyopathy, Hypertrophic" 20013939 miR133a regulates cardiomyocyte hypertrophy in diabetes -other hsa-mir-133a-2 "Cardiomyopathy, Hypertrophic" 20013939 miR133a regulates cardiomyocyte hypertrophy in diabetes -other hsa-let-7c "Carcinoma, Hepatocellular" 20018759 "A set of 12 miRNAs (including miR-21, miR-221/222, miR-34a, miR-519a, miR-93, miR-96, and let-7c) was linked to disease progression from normal liver through cirrhosis to full-blown HCC" -other hsa-mir-21 "Carcinoma, Hepatocellular" 20018759 "A set of 12 miRNAs (including miR-21, miR-221/222, miR-34a, miR-519a, miR-93, miR-96, and let-7c) was linked to disease progression from normal liver through cirrhosis to full-blown HCC" -other hsa-mir-222 "Carcinoma, Hepatocellular" 20018759 "A set of 12 miRNAs (including miR-21, miR-221/222, miR-34a, miR-519a, miR-93, miR-96, and let-7c) was linked to disease progression from normal liver through cirrhosis to full-blown HCC" -other hsa-mir-34a "Carcinoma, Hepatocellular" 20018759 "A set of 12 miRNAs (including miR-21, miR-221/222, miR-34a, miR-519a, miR-93, miR-96, and let-7c) was linked to disease progression from normal liver through cirrhosis to full-blown HCC" -other hsa-mir-93 "Carcinoma, Hepatocellular" 20018759 "A set of 12 miRNAs (including miR-21, miR-221/222, miR-34a, miR-519a, miR-93, miR-96, and let-7c) was linked to disease progression from normal liver through cirrhosis to full-blown HCC" -other hsa-mir-96 "Carcinoma, Hepatocellular" 20018759 "A set of 12 miRNAs (including miR-21, miR-221/222, miR-34a, miR-519a, miR-93, miR-96, and let-7c) was linked to disease progression from normal liver through cirrhosis to full-blown HCC" -other hsa-let-7a Retinoblastoma 20019750 "miRNA profiling of these tumors identified members of the let-7 and miR-34(34b,34c) families as candidate tumor suppressors in retinoblastoma." -other hsa-let-7b Retinoblastoma 20019750 "miRNA profiling of these tumors identified members of the let-7 and miR-34(34b,34c) families as candidate tumor suppressors in retinoblastoma." -other hsa-let-7c Retinoblastoma 20019750 "miRNA profiling of these tumors identified members of the let-7 and miR-34(34b,34c) families as candidate tumor suppressors in retinoblastoma." -other hsa-let-7d Retinoblastoma 20019750 "miRNA profiling of these tumors identified members of the let-7 and miR-34(34b,34c) families as candidate tumor suppressors in retinoblastoma." -other hsa-let-7e Retinoblastoma 20019750 "miRNA profiling of these tumors identified members of the let-7 and miR-34(34b,34c) families as candidate tumor suppressors in retinoblastoma." -other hsa-let-7f Retinoblastoma 20019750 "miRNA profiling of these tumors identified members of the let-7 and miR-34(34b,34c) families as candidate tumor suppressors in retinoblastoma." -other hsa-let-7g Retinoblastoma 20019750 "miRNA profiling of these tumors identified members of the let-7 and miR-34(34b,34c) families as candidate tumor suppressors in retinoblastoma." -other hsa-let-7i Retinoblastoma 20019750 "miRNA profiling of these tumors identified members of the let-7 and miR-34(34b,34c) families as candidate tumor suppressors in retinoblastoma." -other hsa-mir-202 Retinoblastoma 20019750 "miRNA profiling of these tumors identified members of the let-7 and miR-34(34b,34c) families as candidate tumor suppressors in retinoblastoma." -other hsa-mir-34b Retinoblastoma 20019750 "miRNA profiling of these tumors identified members of the let-7 and miR-34(34b,34c) families as candidate tumor suppressors in retinoblastoma." -other hsa-mir-34c Retinoblastoma 20019750 "miRNA profiling of these tumors identified members of the let-7 and miR-34(34b,34c) families as candidate tumor suppressors in retinoblastoma." -other hsa-mir-98 Retinoblastoma 20019750 "miRNA profiling of these tumors identified members of the let-7 and miR-34(34b,34c) families as candidate tumor suppressors in retinoblastoma." -other hsa-mir-20a "Carcinoma, Renal Cell" 20022054 Transfection of miR-20a inhibitor significantly decreased cell proliferation in a dose dependent manner. -other hsa-mir-100 Gastric Neoplasms 20022810 "progression-related signature, miR-125b, miR-199a, and miR-100 were the most important microRNAs involved" -other hsa-mir-146a Kaposi Sarcoma 20023696 Our results show that K13-induced NF-kappaB activity suppresses CXCR4 through upregulation of miR-146a. -other hsa-mir-200a Ovarian Neoplasms 20035894 miR-200a:involved in epithelial-to-mesenchymal transition (EMT) -other hsa-mir-200b Ovarian Neoplasms 20035894 miR-200b:involved in epithelial-to-mesenchymal transition (EMT) -other hsa-mir-200c Ovarian Neoplasms 20035894 miR-200c:involved in epithelial-to-mesenchymal transition (EMT) -other hsa-mir-1-1 Chordoma 20041488 miR-1:miRNA-1 may have a functional effect on chordoma tumor pathogenesis -other hsa-mir-1-2 Chordoma 20041488 miR-1:miRNA-1 may have a functional effect on chordoma tumor pathogenesis -other hsa-mir-128a Breast Neoplasms 20054641 These data suggest that the hormone-responsive miR-128a can modulate TGF¦Â signaling and survival of the letrozole-resistant cell lines. -other hsa-mir-132 Inflammation 20064444 Boosting the brain's ability to block inflammation via microRNA-132. -other hsa-mir-10b Esophageal Neoplasms 20075075 MicroRNA-10b promotes migration and invasion through KLF4 in human esophageal cancer cell lines. -other hsa-mir-21 Breast Neoplasms 20082533 Downregulation of miR-21 enhances chemotherapeutic effect of taxol in breast carcinoma cells -other hsa-mir-130a Ovarian Neoplasms 20083225 "we discuss several other microRNAs that have been associated with chemotherapy resistance, such as miR-214, miR-130a, miR-27a and miR-451. In the final section, we speculate on the possibilities of microRNA-based therapies and the use of microRNAs as diagnostic tools." -other hsa-mir-214 Ovarian Neoplasms 20083225 "we discuss several other microRNAs that have been associated with chemotherapy resistance, such as miR-214, miR-130a, miR-27a and miR-451. In the final section, we speculate on the possibilities of microRNA-based therapies and the use of microRNAs as diagnostic tools." -other hsa-mir-27a Ovarian Neoplasms 20083225 "we discuss several other microRNAs that have been associated with chemotherapy resistance, such as miR-214, miR-130a, miR-27a and miR-451. In the final section, we speculate on the possibilities of microRNA-based therapies and the use of microRNAs as diagnostic tools." -other hsa-mir-451 Ovarian Neoplasms 20083225 "we discuss several other microRNAs that have been associated with chemotherapy resistance, such as miR-214, miR-130a, miR-27a and miR-451. In the final section, we speculate on the possibilities of microRNA-based therapies and the use of microRNAs as diagnostic tools." -other hsa-mir-23a Neoplasms [unspecific] 20086171 "In addition to its known function in regulating the cell cycle and glucose metabolism, recent studies document a role for Myc in stimulating glutamine catabolism, in part through the repression of miRNAs miR-23a and miR-23b." -other hsa-mir-23b Neoplasms [unspecific] 20086171 "In addition to its known function in regulating the cell cycle and glucose metabolism, recent studies document a role for Myc in stimulating glutamine catabolism, in part through the repression of miRNAs miR-23a and miR-23b." -other hsa-mir-146a Diabetes Mellitus 20086228 "Our data identify miR-21, miR-34a, and miR-146a as novel players in beta-cell failure elicited in vitro and in vivo by proinflammatory cytokines,notably during the development of peri-insulitis that precedes overt diabetes in NOD mice." -other hsa-mir-21 Diabetes Mellitus 20086228 "Our data identify miR-21, miR-34a, and miR-146a as novel players in beta-cell failure elicited in vitro and in vivo by proinflammatory cytokines,notably during the development of peri-insulitis that precedes overt diabetes in NOD mice." -other hsa-mir-34a Diabetes Mellitus 20086228 "Our data identify miR-21, miR-34a, and miR-146a as novel players in beta-cell failure elicited in vitro and in vivo by proinflammatory cytokines,notably during the development of peri-insulitis that precedes overt diabetes in NOD mice." -other hsa-mir-29a "Lymphoma, B-Cell" 20086245 "our results in primary MCL cells indicate that down-regulation of miR-29 could cooperate with cyclin D1 in MCL pathogenesis. Thus, our findings provide not only miRNA expression signature but also a novel prognostic marker and pathogenetic factor for this malignancy." -other hsa-mir-106b Toxoplasma gondii Infection 20090903 play crucial roles in mammalian cell regulation and have been implicated in numerous hyperproliferative diseases -other hsa-mir-17 Toxoplasma gondii Infection 20090903 play crucial roles in mammalian cell regulation and have been implicated in numerous hyperproliferative diseases -other hsa-mir-18a Toxoplasma gondii Infection 20090903 play crucial roles in mammalian cell regulation and have been implicated in numerous hyperproliferative diseases -other hsa-mir-19a Toxoplasma gondii Infection 20090903 play crucial roles in mammalian cell regulation and have been implicated in numerous hyperproliferative diseases -other hsa-mir-19b-1 Toxoplasma gondii Infection 20090903 play crucial roles in mammalian cell regulation and have been implicated in numerous hyperproliferative diseases -other hsa-mir-19b-2 Toxoplasma gondii Infection 20090903 play crucial roles in mammalian cell regulation and have been implicated in numerous hyperproliferative diseases -other hsa-mir-20a Toxoplasma gondii Infection 20090903 play crucial roles in mammalian cell regulation and have been implicated in numerous hyperproliferative diseases -other hsa-mir-21 Prostate Neoplasms 20092645 oncogenic properties of miR-21 could be cell and tissue dependent -other hsa-mir-143 Colorectal Carcinoma 20094072 anti-oncomirs -other hsa-let-7a-1 Lung Neoplasms 20097187 inhibition of proliferation in non-small cell lung cancer -other hsa-let-7a-2 Lung Neoplasms 20097187 inhibition of proliferation in non-small cell lung cancer -other hsa-let-7a-3 Lung Neoplasms 20097187 inhibition of proliferation in non-small cell lung cancer -other hsa-mir-126 Lung Neoplasms 20097187 inhibition of proliferation in non-small cell lung cancer -other hsa-mir-145 Lung Neoplasms 20097187 inhibition of proliferation in non-small cell lung cancer -other hsa-mir-146a "Leukemia, Myeloid, Acute" 20110180 "Of them, three (i.e., miR-146a, miR-181a/c, and miR-221), five (i.e., miR-25, miR-26a, miR-29b, miR-146a, and miR-196b), and three (i.e.,miR-26a, miR-29b, and miR-146a) miRNAs are significantly associated with overall survival (P<0.05) of the 32 ALL, 53 AML, and 40 non-M3 AML patients," -other hsa-mir-146a "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 20110180 "Of them, three (i.e., miR-146a, miR-181a/c, and miR-221), five (i.e., miR-25, miR-26a, miR-29b, miR-146a, and miR-196b), and three (i.e.,miR-26a, miR-29b, and miR-146a) miRNAs are significantly associated with overall survival (P<0.05) of the 32 ALL, 53 AML, and 40 non-M3 AML patients," -other hsa-mir-181a-2 "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 20110180 "Of them, three (i.e., miR-146a, miR-181a/c, and miR-221), five (i.e., miR-25, miR-26a, miR-29b, miR-146a, and miR-196b), and three (i.e.,miR-26a, miR-29b, and miR-146a) miRNAs are significantly associated with overall survival (P<0.05) of the 32 ALL, 53 AML, and 40 non-M3 AML patients," -other hsa-mir-181c "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 20110180 "Of them, three (i.e., miR-146a, miR-181a/c, and miR-221), five (i.e., miR-25, miR-26a, miR-29b, miR-146a, and miR-196b), and three (i.e.,miR-26a, miR-29b, and miR-146a) miRNAs are significantly associated with overall survival (P<0.05) of the 32 ALL, 53 AML, and 40 non-M3 AML patients," -other hsa-mir-196b "Leukemia, Myeloid, Acute" 20110180 "Of them, three (i.e., miR-146a, miR-181a/c, and miR-221), five (i.e., miR-25, miR-26a, miR-29b, miR-146a, and miR-196b), and three (i.e.,miR-26a, miR-29b, and miR-146a) miRNAs are significantly associated with overall survival (P<0.05) of the 32 ALL, 53 AML, and 40 non-M3 AML patients," -other hsa-mir-221 "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 20110180 "Of them, three (i.e., miR-146a, miR-181a/c, and miR-221), five (i.e., miR-25, miR-26a, miR-29b, miR-146a, and miR-196b), and three (i.e.,miR-26a, miR-29b, and miR-146a) miRNAs are significantly associated with overall survival (P<0.05) of the 32 ALL, 53 AML, and 40 non-M3 AML patients," -other hsa-mir-25 "Leukemia, Myeloid, Acute" 20110180 "Of them, three (i.e., miR-146a, miR-181a/c, and miR-221), five (i.e., miR-25, miR-26a, miR-29b, miR-146a, and miR-196b), and three (i.e.,miR-26a, miR-29b, and miR-146a) miRNAs are significantly associated with overall survival (P<0.05) of the 32 ALL, 53 AML, and 40 non-M3 AML patients," -other hsa-mir-26a-1 "Leukemia, Myeloid, Acute" 20110180 "Of them, three (i.e., miR-146a, miR-181a/c, and miR-221), five (i.e., miR-25, miR-26a, miR-29b, miR-146a, and miR-196b), and three (i.e.,miR-26a, miR-29b, and miR-146a) miRNAs are significantly associated with overall survival (P<0.05) of the 32 ALL, 53 AML, and 40 non-M3 AML patients," -other hsa-mir-26a-2 "Leukemia, Myeloid, Acute" 20110180 "Of them, three (i.e., miR-146a, miR-181a/c, and miR-221), five (i.e., miR-25, miR-26a, miR-29b, miR-146a, and miR-196b), and three (i.e.,miR-26a, miR-29b, and miR-146a) miRNAs are significantly associated with overall survival (P<0.05) of the 32 ALL, 53 AML, and 40 non-M3 AML patients," -other hsa-mir-29b-1 "Leukemia, Myeloid, Acute" 20110180 "Of them, three (i.e., miR-146a, miR-181a/c, and miR-221), five (i.e., miR-25, miR-26a, miR-29b, miR-146a, and miR-196b), and three (i.e.,miR-26a, miR-29b, and miR-146a) miRNAs are significantly associated with overall survival (P<0.05) of the 32 ALL, 53 AML, and 40 non-M3 AML patients," -other hsa-mir-29b-2 "Leukemia, Myeloid, Acute" 20110180 "Of them, three (i.e., miR-146a, miR-181a/c, and miR-221), five (i.e., miR-25, miR-26a, miR-29b, miR-146a, and miR-196b), and three (i.e.,miR-26a, miR-29b, and miR-146a) miRNAs are significantly associated with overall survival (P<0.05) of the 32 ALL, 53 AML, and 40 non-M3 AML patients," -other hsa-mir-221 Inflammation 20110463 "Functional inhibition of miR-221 with anti-miR-221 induced ICAM-1 protein expression. Moreover, IFN-gamma stimulation decreased miR-221 expression in cholangiocytes in a signal transducer and activator of transcription 1-dependent manner." -other hsa-mir-146a Pancreatic Neoplasms 20124483 miR-146a suppresses invasion of pancreatic cancer cells. -other hsa-mir-200a Urinary Bladder Cancer 20124485 play important regulatory roles in cervical cancer control -other hsa-mir-196a-1 "Carcinoma, Hepatocellular" 20127796 miR-196:MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression -other hsa-mir-196a-2 "Carcinoma, Hepatocellular" 20127796 miR-196:MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression -other hsa-mir-27b Osteoarthritis 20131257 miR-27b:MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes -other hsa-mir-155 Lymphoma 20133617 "Together, our data helped explain miR-155 function, highlighted a hitherto unappreciated role of SMAD5 in lymphoma biology, and defined a unique mechanism used by cancer cells to escape TGF-beta's growth-inhibitory effects." -other hsa-mir-125b-1 Neoplasms [unspecific] 20144731 "miR-125b:in macrophages, miR-125b, miR-146, and miR-155 act as Pathogen Associated Molecular Pattern Molecule-associated microRNAs" -other hsa-mir-125b-2 Neoplasms [unspecific] 20144731 "miR-125b:in macrophages, miR-125b, miR-146, and miR-155 act as Pathogen Associated Molecular Pattern Molecule-associated microRNAs" -other hsa-mir-146a Neoplasms [unspecific] 20144731 "miR-146:in macrophages, miR-125b, miR-146, and miR-155 act as Pathogen Associated Molecular Pattern Molecule-associated microRNAs" -other hsa-mir-155 Neoplasms [unspecific] 20144731 "miR-155:in macrophages, miR-125b, miR-146, and miR-155 act as Pathogen Associated Molecular Pattern Molecule-associated microRNAs" -other hsa-mir-17 Neoplasms [unspecific] 20144731 "miR-17:Targets identified already in T cells include microRNAs, miR-17-92 family, miR-155, and miR-181a" -other hsa-mir-181a-1 Neoplasms [unspecific] 20144731 "miR-181a:Targets identified already in T cells include microRNAs, miR-17-92 family, miR-155, and miR-181a" -other hsa-mir-181a-2 Neoplasms [unspecific] 20144731 "miR-181a:Targets identified already in T cells include microRNAs, miR-17-92 family, miR-155, and miR-181a" -other hsa-mir-18a Neoplasms [unspecific] 20144731 "miR-18a:Targets identified already in T cells include microRNAs, miR-17-92 family, miR-155, and miR-181a" -other hsa-mir-19a Neoplasms [unspecific] 20144731 "miR-19a:Targets identified already in T cells include microRNAs, miR-17-92 family, miR-155, and miR-181a" -other hsa-mir-19b-1 Neoplasms [unspecific] 20144731 "miR-19b:Targets identified already in T cells include microRNAs, miR-17-92 family, miR-155, and miR-181a" -other hsa-mir-19b-2 Neoplasms [unspecific] 20144731 "miR-19b:Targets identified already in T cells include microRNAs, miR-17-92 family, miR-155, and miR-181a" -other hsa-mir-20a Neoplasms [unspecific] 20144731 "miR-20a:Targets identified already in T cells include microRNAs, miR-17-92 family, miR-155, and miR-181a" -other hsa-mir-214 Neoplasms [unspecific] 20144731 miR-214:miR-34C and miR-214 as Damage Associated Molecular Pattern Molecules-associated miRs -other hsa-mir-34c Neoplasms [unspecific] 20144731 miR-34c:miR-34C and miR-214 as Damage Associated Molecular Pattern Molecules-associated miRs -other hsa-mir-92a-1 Neoplasms [unspecific] 20144731 "miR-92a:Targets identified already in T cells include microRNAs, miR-17-92 family, miR-155, and miR-181a" -other hsa-mir-92a-2 Neoplasms [unspecific] 20144731 "miR-92a:Targets identified already in T cells include microRNAs, miR-17-92 family, miR-155, and miR-181a" -other hsa-mir-31 Neoplasms [unspecific] 20145132 miR-31 ablates expression of the HIF regulatory factor FIH to activate the HIF pathway in head and neck carcinoma -other hsa-mir-125b-1 Melanoma 20153427 "miR-125b:miRNA125b may be involved in the regulation of VDR expression and in the resistance against 1,25(OH)(2)D(3) in melanoma cells" -other hsa-mir-125b-2 Melanoma 20153427 "miR-125b:miRNA125b may be involved in the regulation of VDR expression and in the resistance against 1,25(OH)(2)D(3) in melanoma cells" -other hsa-mir-21 Prostate Neoplasms 20160498 "The transcriptional regulation of miR-21, its multiple transcripts, and their implication in prostate cancer" -other hsa-mir-1 Myocardial Infarction 20163779 We conclude that miR-1 and miR-133 seem to be important regulators of heart adaptation after ischaemic stress. -other hsa-mir-133b Myocardial Infarction 20163779 We conclude that miR-1 and miR-133 seem to be important regulators of heart adaptation after ischaemic stress. -other hsa-mir-27b Inflammation 20164187 We provide evidence that LPS-induced miR-27b contributes to destabilization of PPARgamma1 mRNA. Understanding molecular mechanisms decreasing PPARgamma might help to better appreciate inflammatory diseases. -other hsa-mir-9-1 "Cardiomyopathy, Hypertrophic" 20177053 miR-9 and NFATc3 regulate myocardin in cardiac hypertrophy -other hsa-mir-9-2 "Cardiomyopathy, Hypertrophic" 20177053 miR-9 and NFATc3 regulate myocardin in cardiac hypertrophy -other hsa-mir-9-3 "Cardiomyopathy, Hypertrophic" 20177053 miR-9 and NFATc3 regulate myocardin in cardiac hypertrophy -other hsa-let-7f "Carcinoma, Renal Cell" 20180642 Transfection of miR-224 into HEK-293 cells resulted in decreased KLK1 protein levels. A luciferase assay demonstrated that hsa-let-7f can target KLK10 in the RCC cell line ACHN. -other hsa-mir-224 "Carcinoma, Renal Cell" 20180642 Transfection of miR-224 into HEK-293 cells resulted in decreased KLK1 protein levels. A luciferase assay demonstrated that hsa-let-7f can target KLK10 in the RCC cell line ACHN. -other hsa-mir-34a Brain Neoplasms 20190569 microRNA-34a is tumor suppressive in brain tumors and glioma stem cells -other hsa-mir-34a Glioma 20190569 microRNA-34a is tumor suppressive in brain tumors and glioma stem cells -other hsa-mir-125b-2 Acute Megakaryoblastic Leukemia 20194440 we propose miR-125b-2 as a positive regulator of megakaryopoiesis and an oncomiR involved in the pathogenesis of trisomy 21-associated megakaryoblastic leukemia. -other hsa-mir-1-1 "Carcinoma, Lung, Non-Small-Cell" 20194856 significantly associated with overal survival -other hsa-mir-1-2 "Carcinoma, Lung, Non-Small-Cell" 20194856 significantly associated with overal survival -other hsa-mir-30d "Carcinoma, Lung, Non-Small-Cell" 20194856 significantly associated with overal survival -other hsa-mir-30d Lung Neoplasms 20194856 "levels of four miRNAs (ie, miR-486, miR-30d, miR-1 and miR-499) were significantly associated with overall survival" -other hsa-mir-486 "Carcinoma, Lung, Non-Small-Cell" 20194856 significantly associated with overal survival -other hsa-mir-486 Lung Neoplasms 20194856 "levels of four miRNAs (ie, miR-486, miR-30d, miR-1 and miR-499) were significantly associated with overall survival" -other hsa-mir-499a "Carcinoma, Lung, Non-Small-Cell" 20194856 significantly associated with overal survival -other hsa-mir-499a Lung Neoplasms 20194856 "levels of four miRNAs (ie, miR-486, miR-30d, miR-1 and miR-499) were significantly associated with overall survival" -other hsa-mir-146a Acute Coronary Syndrome 20195282 miR-146a in PBMCs modulates Th1 function in patients with acute coronary syndrome -other hsa-mir-146a Atherosclerosis 20195282 "this study also provided evidence that miR-146a treatment in vitro could induce the protein expression of TNF-alpha, MCP-1, NF-kappaB p65, which are key pro-inflammatory cytokines and critical transcription factor in AS" -other hsa-mir-17 Multiple Sclerosis 20201009 "Specifically, miR-17-5p, which is involved in autoimmunity, is upregulated in CD4(+) cells from MS patients" -other hsa-mir-216 "Carcinoma, Hepatocellular" 20206398 We also found an inverse correlation between IGF activation and miR-100/miR-216 levels (FDR<0.05). -other hsa-mir-146a Inflammation 20214679 miR-146a in reactive astrocytes supports the possible involvement of miRNAs in the modulation of the astroglial inflammatory response -other hsa-mir-21 Neoplasms [unspecific] 20219416 "miR-21 serves as a chemosensitive miRNA, while miR-214 and -23a serve as chemoresistant miRNAs in the tongue squamous cell carcinoma lines" -other hsa-mir-214 Neoplasms [unspecific] 20219416 "miR-21 serves as a chemosensitive miRNA, while miR-214 and -23a serve as chemoresistant miRNAs in the tongue squamous cell carcinoma lines" -other hsa-mir-23a Neoplasms [unspecific] 20219416 "miR-21 serves as a chemosensitive miRNA, while miR-214 and -23a serve as chemoresistant miRNAs in the tongue squamous cell carcinoma lines" -other hsa-mir-451a Glioma 20227367 MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells -other hsa-mir-17 Neoplasms [unspecific] 20227518 "mir-17-92, a cluster of miRNAs in the midst of the cancer network" -other hsa-mir-18a Neoplasms [unspecific] 20227518 "mir-17-92, a cluster of miRNAs in the midst of the cancer network" -other hsa-mir-19a Neoplasms [unspecific] 20227518 "mir-17-92, a cluster of miRNAs in the midst of the cancer network" -other hsa-mir-19b-1 Neoplasms [unspecific] 20227518 "mir-17-92, a cluster of miRNAs in the midst of the cancer network" -other hsa-mir-19b-2 Neoplasms [unspecific] 20227518 "mir-17-92, a cluster of miRNAs in the midst of the cancer network" -other hsa-mir-20a Neoplasms [unspecific] 20227518 "mir-17-92, a cluster of miRNAs in the midst of the cancer network" -other hsa-mir-92a-1 Neoplasms [unspecific] 20227518 "miR-92a:mir-17-92, a cluster of miRNAs in the midst of the cancer network" -other hsa-mir-92a-2 Neoplasms [unspecific] 20227518 "miR-92a:mir-17-92, a cluster of miRNAs in the midst of the cancer network" -other hsa-mir-134 Coronary Artery Disease 20230787 "a cluster of three microRNAs including miR-134, miR-198, and miR-370, suggesting that the microRNA signatures can be used to identify patients at risk for acute coronary syndromes" -other hsa-mir-198 Coronary Artery Disease 20230787 "a cluster of three microRNAs including miR-134, miR-198, and miR-370, suggesting that the microRNA signatures can be used to identify patients at risk for acute coronary syndromes" -other hsa-mir-370 Coronary Artery Disease 20230787 "a cluster of three microRNAs including miR-134, miR-198, and miR-370, suggesting that the microRNA signatures can be used to identify patients at risk for acute coronary syndromes" -other hsa-mir-210 Inflammation 20237418 miR-210 appears to function as a master microRNA relevant for the control of diverse functions in the hypoxic state -other hsa-mir-210 Ischemia 20237418 miR-210 appears to function as a master microRNA relevant for the control of diverse functions in the hypoxic state -other hsa-mir-210 Neoplasms [unspecific] 20237418 miR-210 appears to function as a master microRNA relevant for the control of diverse functions in the hypoxic state -other hsa-mir-21 Multiple Myeloma 20302778 miR-21 acts as an oncogene and miR-30b a tumor suppressor gene in MM -other hsa-mir-30b Multiple Myeloma 20302778 miR-21 acts as an oncogene and miR-30b a tumor suppressor gene in MM -other hsa-mir-151a Glioblastoma 20305651 "significantly increases HCC cell migration and invasion in vitro and in vivo, mainly through miR-151-5p, but not through miR-151-3p" -other hsa-mir-17 Glioblastoma 20305691 De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures -other hsa-mir-18a Glioblastoma 20305691 De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures -other hsa-mir-19a Glioblastoma 20305691 De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures -other hsa-mir-19b-1 Glioblastoma 20305691 De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures -other hsa-mir-19b-2 Glioblastoma 20305691 De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures -other hsa-mir-20a Glioblastoma 20305691 De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures -other hsa-mir-126 "Adenocarcinoma, Esophageal" 20309880 "we found that miR-126 expression was associated with tumor cell de-differentiation and lymph node metastasis," -other hsa-mir-16-2 "Adenocarcinoma, Esophageal" 20309880 miR-16-2 was associated with lymph node metastasis -other hsa-mir-195 "Adenocarcinoma, Esophageal" 20309880 miR-195p was associated with higher pathologic disease stages in patients with esophageal adenocarcinoma -other hsa-mir-129-2 Gastric Neoplasms 20331975 We also found that inactivation of SOX4 by siRNA and restoration of miR-129-2 induced apoptosis in gastric cancer cells. -other hsa-mir-1296 Prostate Neoplasms 20332239 Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer -other hsa-mir-155 Pancreatic Adenocarcinoma 20332664 Aberrant MicroRNA-155 expression is an early event in the multistep progression of pancreatic adenocarcinoma -other hsa-mir-21 Neoplasms [unspecific] 20335152 Expression of microRNA-21 in ovarian epithelial carcinoma and its clinical significance -other hsa-mir-107 Breast Neoplasms 20348243 "MicroRNAs are also integral components of this gene regulation network because miR-107, miR-424, miR-570, miR-618, and miR-760 are regulated by 17beta-estradiol along with other microRNAs that can target a significant number of transcripts belonging to one or more estrogen-responsive gene clusters." -other hsa-mir-424 Breast Neoplasms 20348243 "MicroRNAs are also integral components of this gene regulation network because miR-107, miR-424, miR-570, miR-618, and miR-760 are regulated by 17beta-estradiol along with other microRNAs that can target a significant number of transcripts belonging to one or more estrogen-responsive gene clusters." -other hsa-mir-570 Breast Neoplasms 20348243 "MicroRNAs are also integral components of this gene regulation network because miR-107, miR-424, miR-570, miR-618, and miR-760 are regulated by 17beta-estradiol along with other microRNAs that can target a significant number of transcripts belonging to one or more estrogen-responsive gene clusters." -other hsa-mir-618 Breast Neoplasms 20348243 "MicroRNAs are also integral components of this gene regulation network because miR-107, miR-424, miR-570, miR-618, and miR-760 are regulated by 17beta-estradiol along with other microRNAs that can target a significant number of transcripts belonging to one or more estrogen-responsive gene clusters." -other hsa-mir-760 Breast Neoplasms 20348243 "MicroRNAs are also integral components of this gene regulation network because miR-107, miR-424, miR-570, miR-618, and miR-760 are regulated by 17beta-estradiol along with other microRNAs that can target a significant number of transcripts belonging to one or more estrogen-responsive gene clusters." -other hsa-mir-155 Colorectal Carcinoma 20351277 Modulation of mismatch repair and genomic stability by miR-155 -other hsa-mir-10b Neoplasms [unspecific] 20351690 Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model -other hsa-mir-181a-2 Glioblastoma 20353279 MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients -other hsa-mir-181b-1 Glioblastoma 20353279 MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients -other hsa-mir-181b-2 Glioblastoma 20353279 MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients -other hsa-mir-181c Glioblastoma 20353279 MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients -other hsa-mir-181d Glioblastoma 20353279 MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients -other hsa-mir-21 Granulosa Cell Tumor 20357270 MicroRNA 21 Blocks Apoptosis in Mouse Periovulatory Granulosa Cells -other hsa-mir-9 Brain Disease [unspecific] 20362537 These results identify miR-9 as a novel regulator that coordinates the proliferation and migration of hNPCs. -other hsa-mir-204 Head And Neck Neoplasms 20369013 Network modeling identifies molecular functions targeted by miR-204 to suppress head and neck tumor metastasis -other hsa-mir-122 Hepatitis C Virus Infection 20371461 "miR-122, a major regulatory RNA in liver that fine-tunes the expression of over 100 cellular genes and enhances HCV replication" -other hsa-mir-122 Liver Neoplasms 20371461 "miR-122, a major regulatory RNA in liver that fine-tunes the expression of over 100 cellular genes and enhances HCV replication" -other hsa-mir-650 Gastric Neoplasms 20381459 we show that miR-650 is involved in lymphatic and distant metastasis in human gastric cancer -other hsa-mir-27a Breast Neoplasms 20382698 miR-27a:MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells -other hsa-mir-145 Ewing Sarcoma 20382729 EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cells. -other hsa-mir-146a Inflammation 20384865 "functional role of miR-146a in innate immune, inflammatory response, virus infection and human diseases" -other hsa-mir-200a Pancreatic Neoplasms 20388782 miR-200:Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF -other hsa-mir-21 Pancreatic Neoplasms 20388782 miR-21:Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF -other hsa-mir-199a-1 Ovarian Neoplasms 20400975 "miR-199a:TWISTing stemness, inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2/214" -other hsa-mir-199a-2 Ovarian Neoplasms 20400975 "miR-199a:TWISTing stemness, inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2/214" -other hsa-mir-214 Ovarian Neoplasms 20400975 "miR-214:TWISTing stemness, inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2/214" -other hsa-mir-21 Cardiovascular Diseases [unspecific] 20404348 MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand -other hsa-mir-21 Neoplasms [unspecific] 20404348 miR-21:function of AKT by which it inhibits apoptosis through miR-21-dependent suppression of FasL -other hsa-mir-146b Neoplasms [unspecific] 20406109 "miR-146b:potential importance of miR-221, miR-222, and miR-146b in determining the aggressive properties of PTCs" -other hsa-mir-221 Neoplasms [unspecific] 20406109 "miR-221:potential importance of miR-221, miR-222, and miR-146b in determining the aggressive properties of PTCs" -other hsa-mir-222 Neoplasms [unspecific] 20406109 "miR-222:potential importance of miR-221, miR-222, and miR-146b in determining the aggressive properties of PTCs" -other hsa-mir-17 Breast Neoplasms 20406904 microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling -other hsa-mir-20a Breast Neoplasms 20406904 microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling -other hsa-mir-20b Breast Neoplasms 20406904 microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling -other hsa-mir-107 Alzheimer Disease 20413881 MiR-107 is reduced in Alzheimer's disease brain neocortex: validation study. -other hsa-mir-296 Atherosclerosis 20415654 Tumor angiogenesis is additionally controlled by miR-296 and miR-378. -other hsa-let-7b Neurodegenerative Diseases [unspecific] 20423455 "Interestingly, both miRNAs are capable of binding directly to TDP-43 in different positions: within the miRNA sequence itself (let-7b) or in the hairpin precursor (miR-663)." -other hsa-mir-663 Neurodegenerative Diseases [unspecific] 20423455 "Interestingly, both miRNAs are capable of binding directly to TDP-43 in different positions: within the miRNA sequence itself (let-7b) or in the hairpin precursor (miR-663)." -other hsa-let-7a-1 "Leukemia, Myeloid, Acute" 20425795 "hsa-let-7a:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes." -other hsa-let-7a-2 "Leukemia, Myeloid, Acute" 20425795 "hsa-let-7a:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes." -other hsa-let-7a-3 "Leukemia, Myeloid, Acute" 20425795 "hsa-let-7a:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes." -other hsa-let-7b "Leukemia, Myeloid, Acute" 20425795 "hsa-let-7b:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes." -other hsa-let-7c "Leukemia, Myeloid, Acute" 20425795 "hsa-let-7c:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes." -other hsa-let-7d "Leukemia, Myeloid, Acute" 20425795 "hsa-let-7d:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes." -other hsa-let-7e "Leukemia, Myeloid, Acute" 20425795 "hsa-let-7e:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes." -other hsa-let-7f-1 "Leukemia, Myeloid, Acute" 20425795 "hsa-let-7f:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes." -other hsa-let-7f-2 "Leukemia, Myeloid, Acute" 20425795 "hsa-let-7f:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes." -other hsa-let-7g "Leukemia, Myeloid, Acute" 20425795 "hsa-let-7g:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes." -other hsa-let-7i "Leukemia, Myeloid, Acute" 20425795 "hsa-let-7i:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes." -other hsa-mir-126 "Leukemia, Myeloid, Acute" 20425795 "miR-126:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes." -other hsa-mir-155 "Leukemia, Myeloid, Acute" 20425795 "miR-155:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes." -other hsa-mir-196b "Leukemia, Myeloid, Acute" 20425795 "miR-196b:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes." -other hsa-mir-221 "Leukemia, Myeloid, Acute" 20425795 "miR-221:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes." -other hsa-mir-98 "Leukemia, Myeloid, Acute" 20425795 "hsa-mir-98:miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes." -other hsa-mir-34a Colon Neoplasms 20433755 "For instance, miR-34a up-regulation corresponded with a down-regulation of BCL2 protein. Treating Par-4-overexpressing HT29 cells with a miR-34a antagomir functionally reversed both BCL2 down-regulation and apoptosis by 5-FU." -other hsa-mir-125b Inflammation 20435889 "The process required to disrupt protein synthesis followed Toll-like receptor 4 (TLR4)-dependent induction of microRNA (miR)-221, miR-579, and miR-125b, which coupled with RNA-binding proteins TTP, AUF1, and TIAR at the 3'-untranslated region to arrest protein synthesis." -other hsa-mir-221 Inflammation 20435889 "The process required to disrupt protein synthesis followed Toll-like receptor 4 (TLR4)-dependent induction of microRNA (miR)-221, miR-579, and miR-125b, which coupled with RNA-binding proteins TTP, AUF1, and TIAR at the 3'-untranslated region to arrest protein synthesis." -other hsa-mir-579 Inflammation 20435889 "The process required to disrupt protein synthesis followed Toll-like receptor 4 (TLR4)-dependent induction of microRNA (miR)-221, miR-579, and miR-125b, which coupled with RNA-binding proteins TTP, AUF1, and TIAR at the 3'-untranslated region to arrest protein synthesis." -other hsa-mir-101-1 "Carcinoma, Hepatocellular" 20444294 miR-101:PKCalpha mediated induction of miR-101 in human hepatoma HepG2 cells -other hsa-mir-101-2 "Carcinoma, Hepatocellular" 20444294 miR-101:PKCalpha mediated induction of miR-101 in human hepatoma HepG2 cells -other hsa-mir-10a Glioblastoma 20444541 "miR-10a:miR-195, miR-455-3p and miR-10a( *) are implicated in acquired temozolomide resistance in glioblastoma multiforme cells" -other hsa-mir-195 Glioblastoma 20444541 "miR-195:miR-195, miR-455-3p and miR-10a( *) are implicated in acquired temozolomide resistance in glioblastoma multiforme cells" -other hsa-mir-455 Glioblastoma 20444541 "miR-455-3p:miR-195, miR-455-3p and miR-10a( *) are implicated in acquired temozolomide resistance in glioblastoma multiforme cells" -other hsa-mir-10b Neoplasms [unspecific] 20444703 miR-10b:miR-10b targets Tiam1: implications for Rac activation and carcinoma migration -other hsa-mir-21 "Carcinoma, Hepatocellular" 20447717 microRNA-21:MicroRNA-21 acts as an oncomir through multiple targets in human hepatocellular carcinoma -other hsa-mir-199a-1 Cardiomegaly 20458739 miR-199a:miR-199a is essential for the maintenance of cell size in cardiomyocytes -other hsa-mir-199a-1 Cardiovascular Diseases [unspecific] 20458739 miR-199a is essential for the maintenance of cell size in cardiomyocytes -other hsa-mir-199a-2 Cardiomegaly 20458739 miR-199a:miR-199a is essential for the maintenance of cell size in cardiomyocytes -other hsa-mir-199a-2 Cardiovascular Diseases [unspecific] 20458739 miR-199a is essential for the maintenance of cell size in cardiomyocytes -other hsa-mir-21 "Adenocarcinoma, Pancreatic Ductal" 20460539 miR-21:miR-21 expression correlated with outcome in PDAC patients treated with gemcitabine -other hsa-mir-221 Neoplasms [unspecific] 20461750 MiR-221:MiR-221 and MiR-222 alterations in sporadic ovarian carcinoma -other hsa-mir-222 Neoplasms [unspecific] 20461750 MiR-222:MiR-221 and MiR-222 alterations in sporadic ovarian carcinoma -other hsa-mir-542 Neuroblastoma 20466808 "miR-542-5p:the putative tumor suppressive microRNAs, miR-542-5p and miR-628, were expressed in favorable NBs and virtually absent in unfavorable NBs" -other hsa-mir-628 Neuroblastoma 20466808 "miR-628:the putative tumor suppressive microRNAs, miR-542-5p and miR-628, were expressed in favorable NBs and virtually absent in unfavorable NBs" -other hsa-mir-140 Osteoarthritis 20466812 "We show that miR-140 regulates cartilage development and homeostasis, and its loss contributes to the development of age-related OA-like changes." -other hsa-mir-125b-1 "Cardiomyopathy, Hypertrophic" 20470752 "miR-125b:miR-23a, miR-27b, miR-125b and miR-195 were induced during early hypertrophic growth" -other hsa-mir-125b-2 "Cardiomyopathy, Hypertrophic" 20470752 "miR-125b:miR-23a, miR-27b, miR-125b and miR-195 were induced during early hypertrophic growth" -other hsa-mir-195 "Cardiomyopathy, Hypertrophic" 20470752 "miR-195:miR-23a, miR-27b, miR-125b and miR-195 were induced during early hypertrophic growth" -other hsa-mir-23a "Cardiomyopathy, Hypertrophic" 20470752 "miR-23a:miR-23a, miR-27b, miR-125b and miR-195 were induced during early hypertrophic growth" -other hsa-mir-27b "Cardiomyopathy, Hypertrophic" 20470752 "miR-27b:miR-23a, miR-27b, miR-125b and miR-195 were induced during early hypertrophic growth" -other hsa-mir-196a-1 Melanoma 20480203 miR-196a:MicroRNA miR-196a is a central regulator of HOX-B7 and BMP4 expression in malignant melanoma -other hsa-mir-196a-2 Melanoma 20480203 miR-196a:MicroRNA miR-196a is a central regulator of HOX-B7 and BMP4 expression in malignant melanoma -other hsa-mir-100 Adrenal Cortex Neoplasms 20484036 "miR-100:differentially regulated in childhood adrenocortical tumors (ACT), including miR-99a and miR-100" -other hsa-mir-99a Adrenal Cortex Neoplasms 20484036 "miR-99a:differentially regulated in childhood adrenocortical tumors (ACT), including miR-99a and miR-100" -other hsa-mir-20b "Lymphoma, Mantle-Cell" 20485376 "miR-20b:miR-20b, whose lack of expression distinguished cases with a survival probability of 56% at 60 months" -other hsa-mir-26a-1 "Lymphoma, Mantle-Cell" 20485376 miR-26a:NF-kappaB subunit nuclear translocation to be regulated by the expression of miR-26a -other hsa-mir-26a-2 "Lymphoma, Mantle-Cell" 20485376 miR-26a:NF-kappaB subunit nuclear translocation to be regulated by the expression of miR-26a -other hsa-mir-21 Coronary Artery Disease 20489163 miR-21:We identified a novel miR-21-dependent mechanism of ADMA-mediated APC dysfunction -other hsa-mir-196b "Leukemia, Lymphoblastic, Acute, Childhood" 20494936 Expression of miR-196b is not exclusively MLL-driven but is especially linked to activation of HOXA genes in pediatric acute lymphoblastic leukemia. -other hsa-mir-27b Melanoma 20495621 "we identified miRNAs that are up- and down-regulated in melanoma cells exposed to a hESC microenvironment, such as miR-302a and miR-27b, respectively." -other hsa-mir-302a Melanoma 20495621 "we identified miRNAs that are up- and down-regulated in melanoma cells exposed to a hESC microenvironment, such as miR-302a and miR-27b, respectively." -other hsa-mir-30a Breast Neoplasms 20498642 Mir-30:Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells -other hsa-mir-21 Pancreatic Neoplasms 20498843 microRNA-21:Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer -other hsa-mir-520h Neoplasms [unspecific] 20501832 miR-520h:Downregulation of microRNA miR-520h by E1A contributes to anticancer activity -other hsa-mir-206 Rhabdomyosarcoma 20502458 MicroRNA-206:MicroRNA-206 expression levels correlate with clinical behaviour of rhabdomyosarcomas -other hsa-mir-21 Glioma 20514462 miR-21:Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3 -other hsa-mir-140 Osteoarthritis 20516192 miR-140:miR-140 has a critical and nonredundant role in cartilage development and homeostasis -other hsa-mir-26a-1 Hypertrophy 20525681 MiR-26a:stretch or enforced expression of miR-26a induces HASMC hypertrophy -other hsa-mir-26a-2 Hypertrophy 20525681 MiR-26a:stretch or enforced expression of miR-26a induces HASMC hypertrophy -other hsa-mir-222 Neoplasms [unspecific] 20525881 "miR-222:five miRNAs that negatively control cell proliferation, including miRNA-34a" -other hsa-mir-224 Neoplasms [unspecific] 20525881 "miR-224:five miRNAs that negatively control cell proliferation, including miRNA-34a" -other hsa-mir-29b-1 Neoplasms [unspecific] 20525881 "miR-29b:five miRNAs that negatively control cell proliferation, including miRNA-34a" -other hsa-mir-29b-2 Neoplasms [unspecific] 20525881 "miR-29b:five miRNAs that negatively control cell proliferation, including miRNA-34a" -other hsa-mir-34a Neoplasms [unspecific] 20525881 "miR-34a:five miRNAs that negatively control cell proliferation, including miRNA-34a" -other hsa-mir-532 Neoplasms [unspecific] 20525881 "miR-532:five miRNAs that negatively control cell proliferation, including miRNA-34a" -other hsa-mir-122 "Carcinoma, Hepatocellular" 20527935 miR-122:Small molecule modifiers of microRNA miR-122 function for the treatment of hepatitis C virus infection and hepatocellular carcinoma -other hsa-mir-122 Hepatitis C Virus Infection 20527935 miR-122:Small molecule modifiers of microRNA miR-122 function for the treatment of hepatitis C virus infection and hepatocellular carcinoma -other hsa-mir-140 Arteriosclerosis Obliterans 20528768 "Global analysis of predicted miRNA targets found significantly reduced expression of genes with target regions compared with those without: hsa-miR-140-3p (P=0.002), hsa-miR-182 (P=0.001), hsa-miR-92a and hsa-miR-92b (P=2.2x10-16)." -other hsa-mir-182 Arteriosclerosis Obliterans 20528768 "Global analysis of predicted miRNA targets found significantly reduced expression of genes with target regions compared with those without: hsa-miR-140-3p (P=0.002), hsa-miR-182 (P=0.001), hsa-miR-92a and hsa-miR-92b (P=2.2x10-16)." -other hsa-mir-92a Arteriosclerosis Obliterans 20528768 "Global analysis of predicted miRNA targets found significantly reduced expression of genes with target regions compared with those without: hsa-miR-140-3p (P=0.002), hsa-miR-182 (P=0.001), hsa-miR-92a and hsa-miR-92b (P=2.2x10-16)." -other hsa-mir-92b Arteriosclerosis Obliterans 20528768 "Global analysis of predicted miRNA targets found significantly reduced expression of genes with target regions compared with those without: hsa-miR-140-3p (P=0.002), hsa-miR-182 (P=0.001), hsa-miR-92a and hsa-miR-92b (P=2.2x10-16)." -other hsa-mir-31 Neoplasms [unspecific] 20530680 "miR-31:Concurrent suppression of integrin alpha5, radixin, and RhoA phenocopies the effects of miR-31 on metastasis" -other hsa-mir-221 Melanoma 20547861 microRNA-221:Human polynucleotide phosphorylase selectively and preferentially degrades microRNA-221 in human melanoma cells -other hsa-mir-196b "Leukemia, Lymphocytic, Chronic, B-Cell" 20549547 miR-196b:Potential tumor suppressive function of miR-196b in B-cell lineage acute lymphoblastic leukemia -other hsa-mir-125b Bladder Neoplasms 20549700 "Taken together, miR-125b may act as a tumor suppressor in bladder urothelium, and downregulation of miR-125b may contribute to the tumorigenesis of bladder cancer." -other hsa-mir-29a "Leukemia, Lymphocytic, Chronic, B-Cell" 20566844 miR-29:dysregulation of miR-29 can contribute to the pathogenesis of indolent B-CLL -other hsa-mir-196a Leukemia 20570349 our results identify miR-196a and miR-196b as ERG regulators and implicate a potential role for these miRNAs in acute leukemia. -other hsa-mir-196b Leukemia 20570349 our results identify miR-196a and miR-196b as ERG regulators and implicate a potential role for these miRNAs in acute leukemia. -other hsa-mir-181a-2 "Carcinoma, Hepatocellular" 20576283 miRNA-181a:Micro-RNA-181a regulates osteopontin-dependent metastatic function in hepatocellular cancer cell lines -other hsa-mir-196a Glioma 20601442 Our results suggest that miR-196 may play a role in the malignant progression of gliomas and may be a prognostic predictor in glioblastomas. -other hsa-mir-212 Cocaine Abuse 20613834 miR-212:miR-212 signalling has a key role in determining vulnerability to cocaine addiction -other hsa-mir-101 Neoplasms [unspecific] 20617180 "Up-regulating miR-101 efficiently reduced the protein levels of DNA-PKcs and ATM in these tumor cells and most importantly, sensitized the tumor cells to radiation in vitro and in vivo." -other hsa-mir-1-1 Distal Myopathy 20619221 miR-1:have a profound influence on multiple myopathies -other hsa-mir-1-1 Hypertrophy 20619221 miR-1:have a profound influence on multiple myopathies -other hsa-mir-1-2 Distal Myopathy 20619221 miR-1:have a profound influence on multiple myopathies -other hsa-mir-1-2 Hypertrophy 20619221 miR-1:have a profound influence on multiple myopathies -other hsa-mir-133a-1 Distal Myopathy 20619221 miR-133:have a profound influence on multiple myopathies -other hsa-mir-133a-1 Hypertrophy 20619221 miR-133:have a profound influence on multiple myopathies -other hsa-mir-133a-2 Distal Myopathy 20619221 miR-133:have a profound influence on multiple myopathies -other hsa-mir-133a-2 Hypertrophy 20619221 miR-133:have a profound influence on multiple myopathies -other hsa-mir-206 Distal Myopathy 20619221 miR-206:have a profound influence on multiple myopathies -other hsa-mir-206 Hypertrophy 20619221 miR-206:have a profound influence on multiple myopathies -other hsa-mir-141 "Carcinoma, Hepatocellular" 20619223 "miR-141:Hsa-miR-141 and hsa-miR-200c, microRNAs that promote epithelial phenotypes, had significantly higher levels in non-hepatic epithelial tumors" -other hsa-mir-200c "Carcinoma, Hepatocellular" 20619223 "miR-200c:Hsa-miR-141 and hsa-miR-200c, microRNAs that promote epithelial phenotypes, had significantly higher levels in non-hepatic epithelial tumors" -other hsa-mir-126 Gastric Neoplasms 20619534 miR-126:miR-126 functions as a tumour suppressor in human gastric cancer -other hsa-let-7i "Squamous Cell Carcinoma, Lung" 20620595 "let-7i:Seven human miRNAs (miR-126, miR-193a-3p, miR-30d, miR-30a, miR-101, let-7i, and miR-15a) were found to be significantly downregulated in lung SCC" -other hsa-mir-143 Colorectal Carcinoma 20620599 miR-143:MiR-21 and miR-143 expressions were quantified by using the quantitative reverse transcription polymerase chain reaction method -other hsa-mir-21 Colorectal Carcinoma 20620599 miR-21:Our results support the hypothesis about oncogenic function of miR-21 -other hsa-mir-134 Central Nervous System Embryonal Tumor 20622856 miR-134:A novel pathway regulates memory and plasticity via SIRT1 and miR-134 -other hsa-mir-34a Atherosclerosis 20627091 MiR-34a:MicroRNA-34a regulation of endothelial senescence -other hsa-mir-34a Cardiovascular Diseases [unspecific] 20627091 MiR-34a:MicroRNA-34a regulation of endothelial senescence -other hsa-let-7a-1 Asthma 20630862 let-7a:Proinflammatory role for let-7 microRNAS in experimental asthma -other hsa-let-7a-2 Asthma 20630862 let-7a:Proinflammatory role for let-7 microRNAS in experimental asthma -other hsa-let-7a-3 Asthma 20630862 let-7a:Proinflammatory role for let-7 microRNAS in experimental asthma -other hsa-let-7b Asthma 20630862 let-7b:Proinflammatory role for let-7 microRNAS in experimental asthma -other hsa-let-7c Asthma 20630862 let-7c:Proinflammatory role for let-7 microRNAS in experimental asthma -other hsa-let-7d Asthma 20630862 let-7d:Proinflammatory role for let-7 microRNAS in experimental asthma -other hsa-let-7e Asthma 20630862 let-7e:Proinflammatory role for let-7 microRNAS in experimental asthma -other hsa-let-7f-1 Asthma 20630862 let-7f:Proinflammatory role for let-7 microRNAS in experimental asthma -other hsa-let-7f-2 Asthma 20630862 let-7f:Proinflammatory role for let-7 microRNAS in experimental asthma -other hsa-let-7g Asthma 20630862 let-7g:Proinflammatory role for let-7 microRNAS in experimental asthma -other hsa-let-7i Asthma 20630862 let-7i:Proinflammatory role for let-7 microRNAS in experimental asthma -other hsa-mir-21 Lung Fibrosis 20643828 miR-21:These experiments demonstrate an important role for miR-21 in fibrotic lung diseases -other hsa-mir-16-1 Neoplasms [unspecific] 20668064 miR-16:miR-16 in the regulation of Wip1 phosphatase in the DNA damage response and mammary tumorigenesis -other hsa-mir-16-2 Neoplasms [unspecific] 20668064 miR-16:miR-16 in the regulation of Wip1 phosphatase in the DNA damage response and mammary tumorigenesis -other hsa-mir-132 Neoplasms [unspecific] 20676106 miR-132:miR-132 was highly expressed in the endothelium of human tumors and hemangiomas -other hsa-mir-146a "Carcinoma, Basal Cell" 20680470 These findings suggest that this functional SNP in pre-miR-146a could contribute to ESCC susceptibility and clinical outcome. -other hsa-mir-34a Prostate Neoplasms 20687223 MiR-34a:MiR-34a attenuates paclitaxel-resistance of hormone-refractory prostate cancer PC3 cells through direct and indirect mechanisms -other hsa-mir-21 "Lymphoma, B-Cell" 20693987 miR-21:OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma -other hsa-mir-212 Cocaine Abuse 20711185 miR-212:miR-212 in dorsal striatum may be important in regulating vulnerability to cocaine addiction -other hsa-mir-335 Neoplasms [unspecific] 20713524 miR-335:miR-335 activates the p53 tumor suppressor pathway to limit cell proliferation and neoplastic cell transformation -other hsa-mir-382 Renal Fibrosis 20716515 The study provided experimental evidence in the form of reciprocal expression at the protein level for a large number of predicted miRNA-target pairs and discovered a novel role of miR-382 and SOD2 in the loss of epithelial characteristics induced by TGF¦Â1. -other hsa-mir-125a "Carcinoma, Lung, Non-Small-Cell" 20719190 hsa-miR-125a-5p was poorly-expressed in lung cancer cells and it could enhance lung cancer cell invasion by up-regulating hsa-miR-125a-5p. -other hsa-mir-195 Colorectal Carcinoma 20727858 miR-195:microRNA-195 promotes apoptosis and suppresses tumorigenicity of human colorectal cancer cells -other hsa-mir-30b Schizophrenia 20732949 These preliminary findings point to the possibility that disease-related changes in the expression of small noncoding RNAs such as miR-30b in schizophrenia could be influenced by gender and potentially regulated by estrogen signaling. -other hsa-mir-145 Myelodysplastic Syndromes 20733155 "Other mouse modeling data suggest that haploinsufficiency of the microRNA genes miR-145 and miR-146a may contribute to the thrombocytosis seen in the 5q- syndrome. Lenalidomide has become an established therapy for the 5q- syndrome, although its precise mode of action remains uncertain." -other hsa-mir-146a Myelodysplastic Syndromes 20733155 "Other mouse modeling data suggest that haploinsufficiency of the microRNA genes miR-145 and miR-146a may contribute to the thrombocytosis seen in the 5q- syndrome. Lenalidomide has become an established therapy for the 5q- syndrome, although its precise mode of action remains uncertain." -other hsa-mir-34a "Carcinoma, Rectal" 20734047 Satraplatin treatment induces p53-related genes and its direct microRNA target of miR-34a independently. -other hsa-mir-205 Prostate Neoplasms 20737563 MicroRNA-205-directed transcriptional activation of tumor suppressor genes in prostate cancer. -other hsa-mir-320a Childhood Leukemia 20807887 "In summary our data suggest that TEL-AML1 might exert its antiapoptotic action at least in part by suppressing miRNA-494 and miRNA-320a, lowering their expression causing enhanced survivin expression." -other hsa-mir-494 Childhood Leukemia 20807887 "In summary our data suggest that TEL-AML1 might exert its antiapoptotic action at least in part by suppressing miRNA-494 and miRNA-320a, lowering their expression causing enhanced survivin expression." -other hsa-let-7a "Carcinoma, Gastric" 20809749 Lentiviral vector-mediated upregulation of let-7a inhibits gastric carcinoma cell growth in vitro and in vivo. -other hsa-mir-146a Ovarian Neoplasms 20810544 Association between hsa-mir-146a genotype and tumor age-of-onset in BRCA1/BRCA2-negative familial breast and ovarian cancer patients. -other hsa-mir-151 "Carcinoma, Hepatocellular" 20812359 MicroRNA-151 and its hosting gene FAK (focal adhesion kinase) regulate tumor cell migration and spreading of hepatocellular carcinoma. -other hsa-mir-451 Glioblastoma 20816946 MiRNA-451 plays a role as tumor suppressor in human glioma cells. -other hsa-mir-145 Breast Neoplasms 20818426 miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness. -other hsa-mir-200a "Carcinoma, Nasopharyngeal" 20826811 Our findings reveal for the first time the function of miR-200a in shifting nasopharyngeal carcinoma cell states via a reversible process coined as epithelial-mesenchymal to stem-like transition through differential and specific mechanisms. -other hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 20832755 miR-21:Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21 -other hsa-mir-210 Myocardial Infarction 20837903 "miR-210:MicroRNA-210 can improve angiogenesis, inhibit apoptosis, and improve cardiac function in a murine model of myocardial infarction." -other hsa-mir-16 Leukemia 20839343 "The murine disease is linked to a genetic abnormality in microRNA mir-15a/16-1 locus, resulting in decreased mature miR-15a/16." -other hsa-mir-146a Rheumatoid Arthritis 20840794 These results indicated that miR-146a was associated with IL-17 expression in the PBMC and synovium in RA patients. There is the possibility that miR-146a participates in the IL-17 expression. -other hsa-mir-17 "Leukemia, Lymphoblastic" 20855495 "NKX3.1 is necessary for T-ALL proliferation, can partially restore proliferation in TAL1 knockdown cells, and directly regulates miR-17-92." -other hsa-mir-18 "Leukemia, Lymphoblastic" 20855495 "NKX3.1 is necessary for T-ALL proliferation, can partially restore proliferation in TAL1 knockdown cells, and directly regulates miR-17-92." -other hsa-mir-19a "Leukemia, Lymphoblastic" 20855495 "NKX3.1 is necessary for T-ALL proliferation, can partially restore proliferation in TAL1 knockdown cells, and directly regulates miR-17-92." -other hsa-mir-19b-1 "Leukemia, Lymphoblastic" 20855495 "NKX3.1 is necessary for T-ALL proliferation, can partially restore proliferation in TAL1 knockdown cells, and directly regulates miR-17-92." -other hsa-mir-20a "Leukemia, Lymphoblastic" 20855495 "NKX3.1 is necessary for T-ALL proliferation, can partially restore proliferation in TAL1 knockdown cells, and directly regulates miR-17-92." -other hsa-mir-92-1 "Leukemia, Lymphoblastic" 20855495 "NKX3.1 is necessary for T-ALL proliferation, can partially restore proliferation in TAL1 knockdown cells, and directly regulates miR-17-92." -other hsa-mir-223 "Leukemia, Lymphocytic, Chronic, B-Cell" 20862275 "miR-223:ZAP70, LPL, CLLU1, microRNA-29c and microRNA-223 were measured by real time PCR in a cohort of 170 patients" -other hsa-mir-29c "Leukemia, Lymphocytic, Chronic, B-Cell" 20862275 "miR-29c:ZAP70, LPL, CLLU1, microRNA-29c and microRNA-223 were measured by real time PCR in a cohort of 170 patients" -other hsa-mir-22 Ovarian Neoplasms 20869762 miR-22:miR-22 might be involved in inhibiting ovarian cancer metastasis -other hsa-mir-380 Neuroblastoma 20871609 In vivo delivery of a miR-380-5p antagonist decreases tumor size in an orthotopic mouse model of neuroblastoma. -other hsa-mir-130b Prostate Neoplasms 20875868 miR-130b:The hsa-miR-130b also shows a high variance between samples. -other hsa-mir-122 Lipid Metabolism Disorder 20880716 "In addition to miR-33, miR-122 and miR-370 have been shown to play important roles in regulating cholesterol and fatty acid metabolism." -other hsa-mir-33 Lipid Metabolism Disorder 20880716 "In addition to miR-33, miR-122 and miR-370 have been shown to play important roles in regulating cholesterol and fatty acid metabolism." -other hsa-mir-370 Lipid Metabolism Disorder 20880716 "In addition to miR-33, miR-122 and miR-370 have been shown to play important roles in regulating cholesterol and fatty acid metabolism." -other hsa-mir-146b Colorectal Carcinoma 20881268 miR-146b-3p and miR-486-5p are more abundant in KRAS mutated samples after cetuximab treatment respect to wild-type ones -other hsa-mir-486 Colorectal Carcinoma 20881268 miR-146b-3p and miR-486-5p are more abundant in KRAS mutated samples after cetuximab treatment respect to wild-type ones -other hsa-mir-103 Metabolic Syndrome 20886002 "Interestingly, a strong correlation was observed between miR-103 and -107 expression, as well as miR-221 and -222 in both experiments." -other hsa-mir-143 Metabolic Syndrome 20886002 "Interestingly, a strong correlation was observed between miR-103 and -107 expression, as well as miR-221 and -222 in both experiments." -other hsa-mir-221 Metabolic Syndrome 20886002 "Interestingly, a strong correlation was observed between miR-103 and -107 expression, as well as miR-221 and -222 in both experiments." -other hsa-mir-222 Metabolic Syndrome 20886002 "Interestingly, a strong correlation was observed between miR-103 and -107 expression, as well as miR-221 and -222 in both experiments." -other hsa-mir-130b Prostate Neoplasms 20890088 We recommend using hsa-miR-130b or the geometric mean of hsa-miR-130b and small RNA RNU6-2 for normalization in miRNA expression studies of prostate cancer. -other hsa-mir-339 Breast Neoplasms 20932331 MiR-339-5p inhibits breast cancer cell migration and invasion in vitro and may be a potential biomarker for breast cancer prognosis. -other hsa-mir-17 Glioblastoma 20940405 "Together, our results define a pathway in which c-Myc activation of miR-17?92 attenuates the TGF¦Â signaling pathway to shut down clusterin expression, thereby stimulating angiogenesis and tumor cell growth." -other hsa-mir-18 Glioblastoma 20940405 "Together, our results define a pathway in which c-Myc activation of miR-17?92 attenuates the TGF¦Â signaling pathway to shut down clusterin expression, thereby stimulating angiogenesis and tumor cell growth." -other hsa-mir-19a Glioblastoma 20940405 "Together, our results define a pathway in which c-Myc activation of miR-17?92 attenuates the TGF¦Â signaling pathway to shut down clusterin expression, thereby stimulating angiogenesis and tumor cell growth." -other hsa-mir-19b-1 Glioblastoma 20940405 "Together, our results define a pathway in which c-Myc activation of miR-17?92 attenuates the TGF¦Â signaling pathway to shut down clusterin expression, thereby stimulating angiogenesis and tumor cell growth." -other hsa-mir-20a Glioblastoma 20940405 "Together, our results define a pathway in which c-Myc activation of miR-17?92 attenuates the TGF¦Â signaling pathway to shut down clusterin expression, thereby stimulating angiogenesis and tumor cell growth." -other hsa-mir-92-1 Glioblastoma 20940405 "Together, our results define a pathway in which c-Myc activation of miR-17?92 attenuates the TGF¦Â signaling pathway to shut down clusterin expression, thereby stimulating angiogenesis and tumor cell growth." -other hsa-mir-192 Multiple Myeloma 20951946 "Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development" -other hsa-mir-194-1 Multiple Myeloma 20951946 "Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development" -other hsa-mir-194-2 Multiple Myeloma 20951946 "Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development" -other hsa-mir-215 Multiple Myeloma 20951946 "Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development" -other hsa-mir-141 Melanoma 20957176 "Overall our findings call into question the general role of miR-200 in suppressing invasion and metastasis, and highlight novel distinguishing characteristics of individual miR-200 family members." -other hsa-mir-200a Melanoma 20957176 "Overall our findings call into question the general role of miR-200 in suppressing invasion and metastasis, and highlight novel distinguishing characteristics of individual miR-200 family members." -other hsa-mir-200b Melanoma 20957176 "Overall our findings call into question the general role of miR-200 in suppressing invasion and metastasis, and highlight novel distinguishing characteristics of individual miR-200 family members." -other hsa-mir-200c Melanoma 20957176 "Overall our findings call into question the general role of miR-200 in suppressing invasion and metastasis, and highlight novel distinguishing characteristics of individual miR-200 family members." -other hsa-mir-429 Melanoma 20957176 "Overall our findings call into question the general role of miR-200 in suppressing invasion and metastasis, and highlight novel distinguishing characteristics of individual miR-200 family members." -other hsa-mir-1 Myocardial Infarction 20959496 "Studies using various in vivo, ex vivo, and in vitro models have suggested the possible involvement of miR-1, miR-21, miR-29, miR-92a,miR-133, miR-199a, and miR-320 in ischemia-reperfusion injury and/or remodeling after myocardial infarction." -other hsa-mir-133 Myocardial Infarction 20959496 "Studies using various in vivo, ex vivo, and in vitro models have suggested the possible involvement of miR-1, miR-21, miR-29, miR-92a,miR-133, miR-199a, and miR-320 in ischemia-reperfusion injury and/or remodeling after myocardial infarction." -other hsa-mir-199a Myocardial Infarction 20959496 "Studies using various in vivo, ex vivo, and in vitro models have suggested the possible involvement of miR-1, miR-21, miR-29, miR-92a,miR-133, miR-199a, and miR-320 in ischemia-reperfusion injury and/or remodeling after myocardial infarction." -other hsa-mir-21 Myocardial Infarction 20959496 "Studies using various in vivo, ex vivo, and in vitro models have suggested the possible involvement of miR-1, miR-21, miR-29, miR-92a,miR-133, miR-199a, and miR-320 in ischemia-reperfusion injury and/or remodeling after myocardial infarction." -other hsa-mir-29 Myocardial Infarction 20959496 "Studies using various in vivo, ex vivo, and in vitro models have suggested the possible involvement of miR-1, miR-21, miR-29, miR-92a,miR-133, miR-199a, and miR-320 in ischemia-reperfusion injury and/or remodeling after myocardial infarction." -other hsa-mir-320 Myocardial Infarction 20959496 "Studies using various in vivo, ex vivo, and in vitro models have suggested the possible involvement of miR-1, miR-21, miR-29, miR-92a,miR-133, miR-199a, and miR-320 in ischemia-reperfusion injury and/or remodeling after myocardial infarction." -other hsa-mir-92a Myocardial Infarction 20959496 "Studies using various in vivo, ex vivo, and in vitro models have suggested the possible involvement of miR-1, miR-21, miR-29, miR-92a,miR-133, miR-199a, and miR-320 in ischemia-reperfusion injury and/or remodeling after myocardial infarction." -other hsa-mir-145 Leukemia 20962326 "As evidence that this subset of miRNAs is relevant to leukemia, we show that loss of 2 miRNAs identified in our analysis, miR-145 and miR-146a, results in leukemia in a mouse model." -other hsa-mir-146a Leukemia 20962326 "As evidence that this subset of miRNAs is relevant to leukemia, we show that loss of 2 miRNAs identified in our analysis, miR-145 and miR-146a, results in leukemia in a mouse model." -other hsa-let-7i "Carcinoma, Renal Cell" 20964835 "This pattern of regulation was also seen in renal cancer tissue for several of these miRNAs (miR-210, miR-155, let-7i and members of the miR-17-92 cluster) when compared with normal tissue." -other hsa-mir-155 "Carcinoma, Renal Cell" 20964835 "This pattern of regulation was also seen in renal cancer tissue for several of these miRNAs (miR-210, miR-155, let-7i and members of the miR-17-92 cluster) when compared with normal tissue." -other hsa-mir-17 "Carcinoma, Renal Cell" 20964835 "This pattern of regulation was also seen in renal cancer tissue for several of these miRNAs (miR-210, miR-155, let-7i and members of the miR-17-92 cluster) when compared with normal tissue." -other hsa-mir-18 "Carcinoma, Renal Cell" 20964835 "This pattern of regulation was also seen in renal cancer tissue for several of these miRNAs (miR-210, miR-155, let-7i and members of the miR-17-92 cluster) when compared with normal tissue." -other hsa-mir-19a "Carcinoma, Renal Cell" 20964835 "This pattern of regulation was also seen in renal cancer tissue for several of these miRNAs (miR-210, miR-155, let-7i and members of the miR-17-92 cluster) when compared with normal tissue." -other hsa-mir-19b-1 "Carcinoma, Renal Cell" 20964835 "This pattern of regulation was also seen in renal cancer tissue for several of these miRNAs (miR-210, miR-155, let-7i and members of the miR-17-92 cluster) when compared with normal tissue." -other hsa-mir-20a "Carcinoma, Renal Cell" 20964835 "This pattern of regulation was also seen in renal cancer tissue for several of these miRNAs (miR-210, miR-155, let-7i and members of the miR-17-92 cluster) when compared with normal tissue." -other hsa-mir-210 "Carcinoma, Renal Cell" 20964835 "This pattern of regulation was also seen in renal cancer tissue for several of these miRNAs (miR-210, miR-155, let-7i and members of the miR-17-92 cluster) when compared with normal tissue." -other hsa-mir-92-1 "Carcinoma, Renal Cell" 20964835 "This pattern of regulation was also seen in renal cancer tissue for several of these miRNAs (miR-210, miR-155, let-7i and members of the miR-17-92 cluster) when compared with normal tissue." -other hsa-mir-199a-1 Heart Failure 20965886 Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart -other hsa-mir-199a-2 Heart Failure 20965886 Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart -other hsa-mir-17 Neuroblastoma 20980091 "Mir-21, an established oncomir in a variety of cancer types, became strongly up-regulated upon MYCN knockdown and the subsequent differentiation." -other hsa-mir-210 "Squamous Cell Carcinoma, Esophageal" 21044961 "Taken together, our findings show an important role for miR-210 as a tumor-suppressive microRNA with effects on cancer cell proliferation." -other hsa-mir-141 Ovarian Neoplasms 21051560 "In conclusion, miR-200 family members(200a,200b,200c,141,429) affect the final ¦Â-tubulin III protein content of ovarian carcinomas. Furthermore, these microRNAs might constitute the biomarkers of response to paclitaxel-based treatments and relapse/progression of advanced stage ovarian carcinoma patients." -other hsa-mir-200a Ovarian Neoplasms 21051560 "In conclusion, miR-200 family members(200a,200b,200c,141,429) affect the final ¦Â-tubulin III protein content of ovarian carcinomas. Furthermore, these microRNAs might constitute the biomarkers of response to paclitaxel-based treatments and relapse/progression of advanced stage ovarian carcinoma patients." -other hsa-mir-200b Ovarian Neoplasms 21051560 "In conclusion, miR-200 family members(200a,200b,200c,141,429) affect the final ¦Â-tubulin III protein content of ovarian carcinomas. Furthermore, these microRNAs might constitute the biomarkers of response to paclitaxel-based treatments and relapse/progression of advanced stage ovarian carcinoma patients." -other hsa-mir-200c Ovarian Neoplasms 21051560 "In conclusion, miR-200 family members(200a,200b,200c,141,429) affect the final ¦Â-tubulin III protein content of ovarian carcinomas. Furthermore, these microRNAs might constitute the biomarkers of response to paclitaxel-based treatments and relapse/progression of advanced stage ovarian carcinoma patients." -other hsa-mir-429 Ovarian Neoplasms 21051560 "In conclusion, miR-200 family members(200a,200b,200c,141,429) affect the final ¦Â-tubulin III protein content of ovarian carcinomas. Furthermore, these microRNAs might constitute the biomarkers of response to paclitaxel-based treatments and relapse/progression of advanced stage ovarian carcinoma patients." -other hsa-mir-34a Melanoma 21051724 The authors' previous studies on miR-34a showed that miRNA can influence the growth of uveal melanoma cells. -other hsa-mir-31 Colon Neoplasms 21062447 "Suppression of microRNA-31 increases sensitivity to 5-FU at an early stage, and affects cell migration and invasion in HCT-116 colon cancer cells." -other hsa-mir-203 "Carcinoma, Rectal" 21063914 miR-203 may be related to the proliferation and invasion of gastric and colorectal cancers. -other hsa-let-7b Melanoma 21087605 "Taken together, the present study identifies let-7b as a tumor suppressor that represses cancer cell proliferation and migration as well as tumor metastasis in mouse melanoma cells." -other hsa-let-7a Lung Neoplasms 21097396 Construction of let-7a expression plasmid and its inhibitory effect on k-Ras protein in A549 lung cancer cells -other hsa-mir-20a Lymphoma 21114763 The pro-senescence role of miR-20a and miR-290 in MEF is apparently in contrast with their proliferative role in tumour and ES cells. -other hsa-mir-584 "Carcinoma, Renal Cell, Clear-Cell" 21119662 Tumour suppressor microRNA-584 directly targets oncogene Rock-1 and decreases invasion ability in human clear cell renal cell carcinoma. -other hsa-let-7a Ovarian Neoplasms 21122376 "Bioinformatic analysis indicated that let-7a, let-7e, let-7f, miR-22 and miR-886-5p may be involved in cancer invasion and metastasis." -other hsa-let-7e Ovarian Neoplasms 21122376 "Bioinformatic analysis indicated that let-7a, let-7e, let-7f, miR-22 and miR-886-5p may be involved in cancer invasion and metastasis." -other hsa-let-7f Ovarian Neoplasms 21122376 "Bioinformatic analysis indicated that let-7a, let-7e, let-7f, miR-22 and miR-886-5p may be involved in cancer invasion and metastasis." -other hsa-mir-22 Ovarian Neoplasms 21122376 "Bioinformatic analysis indicated that let-7a, let-7e, let-7f, miR-22 and miR-886-5p may be involved in cancer invasion and metastasis." -other hsa-mir-886 Ovarian Neoplasms 21122376 "Bioinformatic analysis indicated that let-7a, let-7e, let-7f, miR-22 and miR-886-5p may be involved in cancer invasion and metastasis." -other hsa-mir-203 "Carcinoma, Endometrial" 21125666 "In addition, miR-23b and miR-29c, which are involved in the inhibition of mesenchymal markers, and miR-203, which is involved in the inhibition of cell stemness" -other hsa-mir-23b "Carcinoma, Endometrial" 21125666 "In addition, miR-23b and miR-29c, which are involved in the inhibition of mesenchymal markers, and miR-203, which is involved in the inhibition of cell stemness" -other hsa-mir-29c "Carcinoma, Endometrial" 21125666 "In addition, miR-23b and miR-29c, which are involved in the inhibition of mesenchymal markers, and miR-203, which is involved in the inhibition of cell stemness" -other hsa-mir-192 Neoplasms [unspecific] 21128228 "The meta-analysis also revealed some novel tumor-related miRNAs such as hsa-miR-144, hsa-miR-130b, hsa-miR-132, hsa-miR-154, hsa-miR-192 and hsa-miR-345" -other hsa-mir-34a Cervical Neoplasms 21128241 "In summary, our study demonstrates an intimate connection among oncogenic HPV E6,p53, miR-34a and p18Ink4c and identifies p18Ink4c as a possible biomarker for cervical cancer." -other hsa-mir-21 Breast Neoplasms 21131358 Induction of MIR-21 by retinoic acid in estrogen-receptor-positive breast carcinoma cells: biological correlates and molecular targets -other hsa-mir-373 Prostate Neoplasms 21139802 "The oncogenic mi-croRNAs, miR-373 and miR-520c interact with CD44 in Prostate Cancer" -other hsa-mir-520c Prostate Neoplasms 21139802 "The oncogenic mi-croRNAs, miR-373 and miR-520c interact with CD44 in Prostate Cancer" -other hsa-let-7a-1 Prostate Neoplasms 21148031 RPS2 control let-7a expression in human prostate cancer. -other hsa-mir-92a-1 Esophageal Neoplasms 21148309 microRNA-92a promotes lymph node metastasis of human esophageal squamous cell carcinoma via E-cadherin. -other hsa-mir-92a-2 Esophageal Neoplasms 21148309 microRNA-92a promotes lymph node metastasis of human esophageal squamous cell carcinoma via E-cadherin. -other hsa-mir-206 Lung Neoplasms 21157919 MicroRNA-206 Is Associated With Invasion and Metastasis of Lung Cancer. -other hsa-mir-143 Pancreatic Neoplasms 21159815 Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway. -other hsa-mir-145 Pancreatic Neoplasms 21159815 Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway. -other hsa-mir-203 Prostate Neoplasms 21159887 miR-203 expression is specifically attenuated in bone metastatic prostate cancer suggesting a fundamental anti-metastatic role for this miRNA -other hsa-mir-138-2 Panic Disorder 21168126 "Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 Are Associated with Panic Disorder and Regulate Several Anxiety Candidate Genes and Related Pathways." -other hsa-mir-148a Panic Disorder 21168126 "Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 Are Associated with Panic Disorder and Regulate Several Anxiety Candidate Genes and Related Pathways." -other hsa-mir-22 Panic Disorder 21168126 "Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 Are Associated with Panic Disorder and Regulate Several Anxiety Candidate Genes and Related Pathways." -other hsa-mir-488 Panic Disorder 21168126 "Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 Are Associated with Panic Disorder and Regulate Several Anxiety Candidate Genes and Related Pathways." -other hsa-mir-101-1 Alzheimer Disease 21172309 MicroRNA-101 downregulates Alzheimer's amyloid-beta precursor protein levels in human cell cultures and is differentially expressed. -other hsa-let-7i Liver Neoplasms 21176238 let-7i* is overexpressed in side population of HCC cells compared to fetal liver cells -other hsa-mir-155 Endometrial Neoplasms 21176560 "Hsa-miR-155 may play an important role in the proliferation, and metastasis of endometrial cancer, which may be a indicator in the diagnosis and prognosis of endometrial cancer and may be used as a predictive biomarker." -other hsa-mir-30a Medulloblastoma 21177782 miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma. -other hsa-mir-30a Glioblastoma 21178384 the transcriptional BDNF inhibitor miR-30a-5p was also overexpressed at 6 and 12 h of paroxetine incubation -other hsa-mir-135a Heart Failure 21185128 Possible involvement of microRNAs (miR-135a?) in heart failure associated with 25bp deletion in MYBPC3 (cardiac myosin binding protein C) gene. -other hsa-mir-126 Coronary Artery Disease 21195052 Coronary Artery Disease -other hsa-mir-130a Coronary Artery Disease 21195052 Coronary Artery Disease -other hsa-mir-221 Coronary Artery Disease 21195052 Coronary Artery Disease -other hsa-mir-222 Coronary Artery Disease 21195052 Coronary Artery Disease -other hsa-mir-92a-1 Coronary Artery Disease 21195052 Coronary Artery Disease -other hsa-mir-92a-2 Coronary Artery Disease 21195052 Coronary Artery Disease -other hsa-mir-19a "Lymphoma, B-Cell" 21200023 diffuse large B-cell lymphoma -other hsa-mir-19b-1 "Lymphoma, B-Cell" 21200023 diffuse large B-cell lymphoma -other hsa-mir-19b-2 "Lymphoma, B-Cell" 21200023 diffuse large B-cell lymphoma -other hsa-mir-21 "Lymphoma, B-Cell" 21200023 diffuse large B-cell lymphoma -other hsa-mir-92a-1 "Lymphoma, B-Cell" 21200023 diffuse large B-cell lymphoma -other hsa-mir-92a-2 "Lymphoma, B-Cell" 21200023 diffuse large B-cell lymphoma -other hsa-mir-17 Prostate Neoplasms 21203553 miR-17* Suppresses Tumorigenicity of Prostate Cancer by Inhibiting Mitochondrial Antioxidant Enzymes. -other hsa-mir-100 Prostate Neoplasms 21212412 miR-99 family of microRNAs suppresses the expression of prostate specific antigen and prostate cancer cell proliferation. -other hsa-mir-99a Prostate Neoplasms 21212412 miR-99 family of microRNAs suppresses the expression of prostate specific antigen and prostate cancer cell proliferation. -other hsa-mir-99b Prostate Neoplasms 21212412 miR-99 family of microRNAs suppresses the expression of prostate specific antigen and prostate cancer cell proliferation. -other hsa-mir-153-1 Glioblastoma 21213215 Chromatin-modifying drugs induce miRNA-153 expression to suppress Irs-2 in glioblastoma cell lines -other hsa-mir-145 Ewing Sarcoma 21217773 Hsa-mir-145 is the top EWS-FLI1-repressed microRNA involved in a positive feedback loop in Ewing's sarcoma. -other hsa-mir-143 Gastrointestinal Neoplasms 21219233 "The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors." -other hsa-mir-145 Gastrointestinal Neoplasms 21219233 "The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors." -other hsa-mir-17 Gastrointestinal Neoplasms 21219233 "The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors." -other hsa-mir-18 Gastrointestinal Neoplasms 21219233 "The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors." -other hsa-mir-192 Gastrointestinal Neoplasms 21219233 "The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors." -other hsa-mir-194 Gastrointestinal Neoplasms 21219233 "The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors." -other hsa-mir-19a Gastrointestinal Neoplasms 21219233 "The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors." -other hsa-mir-19b-1 Gastrointestinal Neoplasms 21219233 "The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors." -other hsa-mir-20a Gastrointestinal Neoplasms 21219233 "The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors." -other hsa-mir-21 Gastrointestinal Neoplasms 21219233 "The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors." -other hsa-mir-215 Gastrointestinal Neoplasms 21219233 "The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors." -other hsa-mir-34 Gastrointestinal Neoplasms 21219233 "The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors." -other hsa-mir-7 Gastrointestinal Neoplasms 21219233 "The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors." -other hsa-mir-92-1 Gastrointestinal Neoplasms 21219233 "The review focuses on the role of specific miRNAs (miR-192/194/215 and miR-7) in the differentiation of gastrointestinal epithelium and on the role of tumor-suppressive (miR-34, miR-143, miR-145) and oncogenic miRNAs (miR-21,miR-17-92 cluster) in gastrointestinal tumors." -other hsa-mir-155 "Carcinoma, Lung, Non-Small-Cell" 21219656 The prognostic impact of miR-155 depends on histological subtype and nodal status in NSCLC. -other hsa-mir-221 "Squamous Cell Carcinoma, Oral" 21226887 miR-221 and miR-222 expression increased the growth and tumorigenesis of oral carcinoma cells. -other hsa-mir-222 "Squamous Cell Carcinoma, Oral" 21226887 miR-221 and miR-222 expression increased the growth and tumorigenesis of oral carcinoma cells. -other hsa-mir-200a Neoplasms [unspecific] 21237487 "Down-regulation of microRNAs of the miR-200 family and miR-205, and an altered expression of classic and desmosomal cadherins in spindle cell carcinoma of the head and neck-hallmark of epithelial-mesenchymal transition." -other hsa-mir-200b Neoplasms [unspecific] 21237487 "Down-regulation of microRNAs of the miR-200 family and miR-205, and an altered expression of classic and desmosomal cadherins in spindle cell carcinoma of the head and neck-hallmark of epithelial-mesenchymal transition." -other hsa-mir-200c Neoplasms [unspecific] 21237487 "Down-regulation of microRNAs of the miR-200 family and miR-205, and an altered expression of classic and desmosomal cadherins in spindle cell carcinoma of the head and neck-hallmark of epithelial-mesenchymal transition." -other hsa-mir-205 Neoplasms [unspecific] 21237487 "Down-regulation of microRNAs of the miR-200 family and miR-205, and an altered expression of classic and desmosomal cadherins in spindle cell carcinoma of the head and neck-hallmark of epithelial-mesenchymal transition." -other hsa-mir-378a Neoplasms [unspecific] 21242960 Myc/miR-378/TOB2/cyclin D1 functional module regulates oncogenic transformation. -other hsa-mir-23b Urinary Bladder Cancer 21242962 Human papillomavirus type 16 E6 induces cervical cancer cell migration through the p53/microRNA-23b/urokinase-type plasminogen activator pathway. -other hsa-mir-148a Esophageal Neoplasms 21246413 Mir-148a Improves Response to Chemotherapy in Sensitive and Resistant Oesophageal Adenocarcinoma and Squamous Cell Carcinoma Cells. -other hsa-mir-148a "Squamous Cell Carcinoma, Esophageal" 21246413 Mir-148a Improves Response to Chemotherapy in Sensitive and Resistant Oesophageal Adenocarcinoma and Squamous Cell Carcinoma Cells. -other hsa-let-7a Retinoblastoma 21247883 "E2F4 binding sites also occurred near regulatory elements for miRNAs such as let-7a and mir-17, suggestive of regulation of miRNAs by E2F4. Taken together, our genome-wide analysis provided evidence of versatile roles of E2F4 and insights into its functions." -other hsa-mir-17 Retinoblastoma 21247883 "E2F4 binding sites also occurred near regulatory elements for miRNAs such as let-7a and mir-17, suggestive of regulation of miRNAs by E2F4. Taken together, our genome-wide analysis provided evidence of versatile roles of E2F4 and insights into its functions." -other hsa-mir-200c Esophageal Neoplasms 21248297 Overexpression of miR-200c induces chemoresistance in esophageal cancers mediated through activation of the Akt signaling pathway. -other hsa-mir-146a "Diabetes Mellitus, Type 2" 21249428 Impaired miR-146a expression links subclinical inflammation and insulin resistance in Type 2 diabetes. -other hsa-mir-184 "Carcinoma, Renal Cell" 21253009 "miR-210, miR-184 and miR-206) play pivotal roles in ccRCC development" -other hsa-mir-206 "Carcinoma, Renal Cell" 21253009 "miR-210, miR-184 and miR-206) play pivotal roles in ccRCC development" -other hsa-mir-210 "Carcinoma, Renal Cell" 21253009 "miR-210, miR-184 and miR-206) play pivotal roles in ccRCC development" -other hsa-mir-146a Periodontal Diseases 21263019 Polymicrobial Infection with Periodontal Pathogens Specifically enhances miR-146a in ApoE-/- Mice during Experimental Periodontal Disease. -other hsa-mir-205 "Carcinoma, Lung, Non-Small-Cell" 21263248 "In conclusion, the relative quantification of miR-205 and miR-21 seems to be a promising diagnostic tool" -other hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 21263248 "In conclusion, the relative quantification of miR-205 and miR-21 seems to be a promising diagnostic tool" -other hsa-mir-34a Neuroblastoma 21266077 This microRNA is a potent tumor suppressor molecule in vivo in neuroblastoma. -other hsa-mir-1258 Breast Neoplasms 21266359 Suppresses Breast Cancer Brain Metastasis by Targeting Heparanase. -other hsa-mir-146b Glioblastoma 21266476 Induction of miR-146b by PDGF-BB is modulated via MAPK-dependent induction of c-fos. -other hsa-mir-146b Ovarian Neoplasms 21266476 Induction of miR-146b by PDGF-BB is modulated via MAPK-dependent induction of c-fos. -other hsa-mir-143 Colon Neoplasms 21276449 The ecotropic viral integration site 1 oncoprotein (Evi1) is a transcriptional suppressor of the miRNA-143 gene. -other hsa-mir-429 Ovarian Neoplasms 21277012 Overexpression of miR-429 induces mesenchymal-to-epithelial transition (MET) in metastatic ovarian cancer cells. -other hsa-mir-21 Colon Neoplasms 21279518 PDCD4 nuclear loss inversely correlates with miR-21 levels in colon carcinogenesis. -other hsa-mir-203 Rheumatoid Arthritis 21279994 elevated levels of miR-203 lead to increased secretion of MMP-1 and IL-6 via the NF-kB pathway and thereby contribute to the activated phenotype of synovial fibroblasts in RA. -other hsa-mir-155 Cystic Fibrosis 21282106 Elevated miR-155 promotes inflammation in cystic fibrosis by driving hyper-expression of interleukin-8. -other hsa-mir-155 Inflammation 21282106 Elevated miR-155 promotes inflammation in cystic fibrosis by driving hyper-expression of interleukin-8. -other hsa-mir-24-1 Inflammation 21282569 "Role of miR-204 in the regulation of apoptosis, ER stress response, and inflammation in human trabecular meshwork cells." -other hsa-mir-24-2 Inflammation 21282569 "Role of miR-204 in the regulation of apoptosis, ER stress response, and inflammation in human trabecular meshwork cells." -other hsa-mir-199a-1 Liver Cirrhosis 21283674 "In both the mouse and human studies, the expression levels of miR-199a, 199a*, 200a, and 200b were positively and significantly correlated to the progressed liver fibrosis." -other hsa-mir-199a-2 Liver Cirrhosis 21283674 "In both the mouse and human studies, the expression levels of miR-199a, 199a*, 200a, and 200b were positively and significantly correlated to the progressed liver fibrosis." -other hsa-mir-200a Liver Cirrhosis 21283674 "In both the mouse and human studies, the expression levels of miR-199a, 199a*, 200a, and 200b were positively and significantly correlated to the progressed liver fibrosis." -other hsa-mir-200b Liver Cirrhosis 21283674 "In both the mouse and human studies, the expression levels of miR-199a, 199a*, 200a, and 200b were positively and significantly correlated to the progressed liver fibrosis." -other hsa-mir-106b Colon Neoplasms 21283757 Butyrate-induced p21 protein expression was dampened by treatment with a miR-106b mimic. -other hsa-mir-200a Pancreatic Neoplasms 21285251 DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism. -other hsa-mir-33a Inflammation 21285396 "miR-33 reduces RIP140 coactivator activity for NF-kB, which is supported by the reduction in NF-kB reporter activity and the inflammatory potential in macrophages." -other hsa-mir-33b Inflammation 21285396 "miR-33 reduces RIP140 coactivator activity for NF-kB, which is supported by the reduction in NF-kB reporter activity and the inflammatory potential in macrophages." -other hsa-mir-375 Obesity 21291493 "Taken together, these data suggest that miR-375 promotes 3T3-L1 adipocyte differentiation, possibly through modulating the ERK-PPAR¦Ã2-aP2 pathway." -other hsa-let-7a-1 Head And Neck Neoplasms 21292542 MicroRNA let-7a represses chemoresistance and tumourigenicity in head and neck cancer via stem-like properties ablation. -other hsa-let-7a-2 Head And Neck Neoplasms 21292542 MicroRNA let-7a represses chemoresistance and tumourigenicity in head and neck cancer via stem-like properties ablation. -other hsa-let-7a-3 Head And Neck Neoplasms 21292542 MicroRNA let-7a represses chemoresistance and tumourigenicity in head and neck cancer via stem-like properties ablation. -other hsa-mir-193a "Squamous Cell Carcinoma, Head and Neck" 21293058 "miR-193a-5p, expression of which was repressed by p63, was activated by proapoptotic p73 isoforms in both normal cells and tumor cells in vivo." -other hsa-mir-200c Head And Neck Neoplasms 21294122 MicroRNA-200c attenuates tumour growth and metastasis of presumptive head and neck squamous cell carcinoma stem cells. -other hsa-mir-200c "Squamous Cell Carcinoma, Head and Neck" 21294122 MicroRNA-200c attenuates tumour growth and metastasis of presumptive head and neck squamous cell carcinoma stem cells. -other hsa-let-7e "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-let-7f-1 "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-let-7f-2 "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-100 "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-103a-1 "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-103a-2 "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-107 "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-1202 "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-125a "Carcinoma, Hepatocellular" 21298008 miR-125a-5p recurence related -other hsa-mir-125b-1 "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-125b-2 "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-126 "Carcinoma, Hepatocellular" 21298008 miR-126* recurence related -other hsa-mir-129-1 "Carcinoma, Hepatocellular" 21298008 miR-129-5p recurence related -other hsa-mir-129-2 "Carcinoma, Hepatocellular" 21298008 miR-129-5p recurence related -other hsa-mir-140 "Carcinoma, Hepatocellular" 21298008 miR-140-3p recurence related -other hsa-mir-142 "Carcinoma, Hepatocellular" 21298008 miR-142-3p recurence related -other hsa-mir-145 "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-148a "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-18a "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-18b "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-191 "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-195 "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-21 "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-22 "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-221 "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-222 "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-23a "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-24-1 "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-24-2 "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-27a "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-362 "Carcinoma, Hepatocellular" 21298008 miR-362-3p recurence related -other hsa-mir-378a "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-425 "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-497 "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-96 "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-99a "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-99b "Carcinoma, Hepatocellular" 21298008 recurence related -other hsa-mir-206 Breast Neoplasms 21302623 miR-206 may suppress invasion and migration of MDA-MB-231 cells in vitro partly via regulating actin cytoskeleton remodelling such as filopodia formation -other hsa-mir-146b Asthma 21305051 "Inverse correlation with the expression of potential mRNA targets identified mmu-miR-146b, -223, -29b, -29c, -483, -574-5p, -672 and -690 as the best candidates for an active implication in asthma pathogenesis. " -other hsa-mir-223 Asthma 21305051 "Inverse correlation with the expression of potential mRNA targets identified mmu-miR-146b, -223, -29b, -29c, -483, -574-5p, -672 and -690 as the best candidates for an active implication in asthma pathogenesis. " -other hsa-mir-29b Asthma 21305051 "Inverse correlation with the expression of potential mRNA targets identified mmu-miR-146b, -223, -29b, -29c, -483, -574-5p, -672 and -690 as the best candidates for an active implication in asthma pathogenesis. " -other hsa-mir-29c Asthma 21305051 "Inverse correlation with the expression of potential mRNA targets identified mmu-miR-146b, -223, -29b, -29c, -483, -574-5p, -672 and -690 as the best candidates for an active implication in asthma pathogenesis. " -other hsa-mir-483 Asthma 21305051 "Inverse correlation with the expression of potential mRNA targets identified mmu-miR-146b, -223, -29b, -29c, -483, -574-5p, -672 and -690 as the best candidates for an active implication in asthma pathogenesis. " -other hsa-mir-574 Asthma 21305051 "Inverse correlation with the expression of potential mRNA targets identified mmu-miR-146b, -223, -29b, -29c, -483, -574-5p, -672 and -690 as the best candidates for an active implication in asthma pathogenesis. " -other hsa-mir-672 Asthma 21305051 "Inverse correlation with the expression of potential mRNA targets identified mmu-miR-146b, -223, -29b, -29c, -483, -574-5p, -672 and -690 as the best candidates for an active implication in asthma pathogenesis. " -other hsa-mir-690 Asthma 21305051 "Inverse correlation with the expression of potential mRNA targets identified mmu-miR-146b, -223, -29b, -29c, -483, -574-5p, -672 and -690 as the best candidates for an active implication in asthma pathogenesis. " -other hsa-mir-542 Neuroblastoma 21310526 MicroRNA-542-5p as a novel tumor suppressor in neuroblastoma. -other hsa-mir-125a Hepatitis B Virus Infection 21317190 "hsa-mir-125a-5p, was found to interact with the viral sequence and to suppress the reporter activity markedly." -other hsa-mir-1224 Neoplasms [unspecific] 21320120 Lipopolysaccharide-induced miR-1224 negatively regulates tumour necrosis factor-alpha gene expression by modulating Sp1. -other hsa-mir-451a "Carcinoma, Lung, Non-Small-Cell" 21329503 Upregulation of microRNA-451 increases cisplatin sensitivity of non-small cell lung cancer cell line (A549). -other hsa-mir-205 "Carcinoma, Renal Cell" 21330408 MicroRNA-205 inhibits Src-mediated oncogenic pathways in renal cancer. -other hsa-mir-16-1 "Carcinoma, Hepatocellular" 21336967 P-glycoprotein enhances radiation-induced apoptotic cell death through the regulation of miR-16 and Bcl-2 expressions in hepatocellular carcinoma cells. -other hsa-mir-16-2 "Carcinoma, Hepatocellular" 21336967 P-glycoprotein enhances radiation-induced apoptotic cell death through the regulation of miR-16 and Bcl-2 expressions in hepatocellular carcinoma cells. -other hsa-mir-155 "Carcinoma, Lung, Non-Small-Cell" 21350005 "Elevated miR-21 (HR 2.06, 1.13-3.75), miR-17 (HR 2.00, 1.10-3.61), and miR-155 (HR 2.37, 1.27-4.42) was associated with worse cancer-specific mortality in the Maryland cohort." -other hsa-mir-17 "Carcinoma, Lung, Non-Small-Cell" 21350005 "Elevated miR-21 (HR 2.06, 1.13-3.75), miR-17 (HR 2.00, 1.10-3.61), and miR-155 (HR 2.37, 1.27-4.42) was associated with worse cancer-specific mortality in the Maryland cohort." -other hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 21350005 "Elevated miR-21 (HR 2.06, 1.13-3.75), miR-17 (HR 2.00, 1.10-3.61), and miR-155 (HR 2.37, 1.27-4.42) was associated with worse cancer-specific mortality in the Maryland cohort." -other hsa-mir-200b Diabetic Retinopathy 21357793 MicroRNA-200b Regulates Vascular Endothelial Growth Factor-Mediated Alterations in Diabetic Retinopathy. -other hsa-mir-29b-1 Breast Neoplasms 21359530 miR-29b regulates migration of human breast cancer cells. -other hsa-mir-29b-2 Breast Neoplasms 21359530 miR-29b regulates migration of human breast cancer cells. -other hsa-mir-145 Prostate Neoplasms 21360565 "SWAP70, actin-binding protein, function as an oncogene targeting tumor-suppressive miR-145 in prostate cancer." -other hsa-mir-144 "Tuberculosis, Pulmonary" 21367459 Modulation of T cell cytokine production by miR-144* with elevated expression in patients with pulmonary tuberculosis. -other hsa-mir-203 Prostate Neoplasms 21368580 "MiR-203 controls proliferation, migration and invasive potential of prostate cancer cell lines." -other hsa-let-7a-1 Breast Neoplasms 21368581 Micro(mi)RNA expression profile of breast cancer epithelial cells treated with the anti-diabetic drug metformin: Induction of the tumor suppressor miRNA let-7a and suppression of the TGFbeta-induced oncomiR miRNA-181a. -other hsa-let-7a-2 Breast Neoplasms 21368581 Micro(mi)RNA expression profile of breast cancer epithelial cells treated with the anti-diabetic drug metformin: Induction of the tumor suppressor miRNA let-7a and suppression of the TGFbe-induced oncomiR miRNA-181a. -other hsa-let-7a-3 Breast Neoplasms 21368581 Micro(mi)RNA expression profile of breast cancer epithelial cells treated with the anti-diabetic drug metformin: Induction of the tumor suppressor miRNA let-7a and suppression of the TGFbeta-induced oncomiR miRNA-181a. -other hsa-mir-181a-2 Breast Neoplasms 21368581 Micro(mi)RNA expression profile of breast cancer epithelial cells treated with the anti-diabetic drug metformin: Induction of the tumor suppressor miRNA let-7a and suppression of the TGFbeta-induced oncomiR miRNA-181a. -other hsa-mir-205 Prostate Neoplasms 21368878 Downregulation of miR-205 and miR-31 confers resistance to chemotherapy-induced apoptosis in prostate cancer cells. -other hsa-mir-31 Prostate Neoplasms 21368878 Downregulation of miR-205 and miR-31 confers resistance to chemotherapy-induced apoptosis in prostate cancer cells. -other hsa-mir-1 Inflammation 21385380 "Acute noxious stimulation with capsaicin also increased the expression of miR-1 and -16 in DRG cells but, on the other hand, in the spinal dorsal horn only a high dose of capsaicin was able to downregulate miR-206 expression." -other hsa-mir-16 Inflammation 21385380 "Acute noxious stimulation with capsaicin also increased the expression of miR-1 and -16 in DRG cells but, on the other hand, in the spinal dorsal horn only a high dose of capsaicin was able to downregulate miR-206 expression." -other hsa-mir-206 Inflammation 21385380 "Acute noxious stimulation with capsaicin also increased the expression of miR-1 and -16 in DRG cells but, on the other hand, in the spinal dorsal horn only a high dose of capsaicin was able to downregulate miR-206 expression." -other hsa-mir-210 Preeclampsia 21388516 Elevated levels of hypoxia-inducible microRNA-210 in preeclampsia. -other hsa-mir-301a Breast Neoplasms 21393507 miR-301 as a crucial oncogene in human breast cancer that acts through multiple pathways and mechanisms to promote nodal or distant relapses. -other hsa-mir-301b Breast Neoplasms 21393507 miR-301 as a crucial oncogene in human breast cancer that acts through multiple pathways and mechanisms to promote nodal or distant relapses. -other hsa-mir-125b-1 Colorectal Carcinoma 21399871 miR-125b is directly involved in cancer progression and is associated with poor prognosis in human colorectal cancer. Our findings suggest that miR-125b could be an important prognostic indicator for colorectal cancer patients. -other hsa-mir-125b-2 Colorectal Carcinoma 21399871 miR-125b is directly involved in cancer progression and is associated with poor prognosis in human colorectal cancer. Our findings suggest that miR-125b could be an important prognostic indicator for colorectal cancer patients. -other hsa-mir-34a Breast Neoplasms 21399894 increased expression of miR-34a in an acquired model of docetaxel resistance in breast cancer. -other hsa-mir-223 Multiple Myeloma 21401705 Expression of CD19 and lack of miR-223 distinguish extramedullary plasmacytoma from multiple myeloma. -other hsa-mir-31 Breast Neoplasms 21406558 Activation of miR-31 function in already-established metastases elicits metastatic regression. -other hsa-mir-16-1 Colorectal Carcinoma 21406606 "Diet and carcinogen exposure modulated a number of microRNAs (miR-16, miR-19b, miR-21, miR26b, miR27b, miR-93 and miR-203) linked to canonical oncogenic signaling pathways." -other hsa-mir-16-2 Colorectal Carcinoma 21406606 "Diet and carcinogen exposure modulated a number of microRNAs (miR-16, miR-19b, miR-21, miR26b, miR27b, miR-93 and miR-203) linked to canonical oncogenic signaling pathways." -other hsa-mir-19b-1 Colorectal Carcinoma 21406606 "Diet and carcinogen exposure modulated a number of microRNAs (miR-16, miR-19b, miR-21, miR26b, miR27b, miR-93 and miR-203) linked to canonical oncogenic signaling pathways." -other hsa-mir-19b-2 Colorectal Carcinoma 21406606 "Diet and carcinogen exposure modulated a number of microRNAs (miR-16, miR-19b, miR-21, miR26b, miR27b, miR-93 and miR-203) linked to canonical oncogenic signaling pathways." -other hsa-mir-203 Colorectal Carcinoma 21406606 "Diet and carcinogen exposure modulated a number of microRNAs (miR-16, miR-19b, miR-21, miR26b, miR27b, miR-93 and miR-203) linked to canonical oncogenic signaling pathways." -other hsa-mir-21 Colorectal Carcinoma 21406606 "Diet and carcinogen exposure modulated a number of microRNAs (miR-16, miR-19b, miR-21, miR26b, miR27b, miR-93 and miR-203) linked to canonical oncogenic signaling pathways." -other hsa-mir-26b Colorectal Carcinoma 21406606 "Diet and carcinogen exposure modulated a number of microRNAs (miR-16, miR-19b, miR-21, miR26b, miR27b, miR-93 and miR-203) linked to canonical oncogenic signaling pathways." -other hsa-mir-27b Colorectal Carcinoma 21406606 "Diet and carcinogen exposure modulated a number of microRNAs (miR-16, miR-19b, miR-21, miR26b, miR27b, miR-93 and miR-203) linked to canonical oncogenic signaling pathways." -other hsa-mir-93 Colorectal Carcinoma 21406606 "Diet and carcinogen exposure modulated a number of microRNAs (miR-16, miR-19b, miR-21, miR26b, miR27b, miR-93 and miR-203) linked to canonical oncogenic signaling pathways." -other hsa-mir-200a Pancreatic Neoplasms 21408027 "Anti-Tumor Activity of a Novel Compound-CDF Is Mediated by Regulating miR-21, miR-200, and PTEN in Pancreatic Cancer." -other hsa-mir-200b Pancreatic Neoplasms 21408027 in gemcitabine-resistant (MIAPaCa-2) PC cells containing high proportion of CSCs consistent with increased miR-21 and decreased miR-200. -other hsa-mir-200c Pancreatic Neoplasms 21408027 in gemcitabine-resistant (MIAPaCa-2) PC cells containing high proportion of CSCs consistent with increased miR-21 and decreased miR-200. -other hsa-mir-21 Pancreatic Neoplasms 21408027 "Anti-Tumor Activity of a Novel Compound-CDF Is Mediated by Regulating miR-21, miR-200, and PTEN in Pancreatic Cancer." -other hsa-let-7c Breast Neoplasms 21409395 "let7c, miR-125b, miR-126, miR-127-3p, miR-143, miR-145, miR-146b-5p, and miR-199a-3p), preferentially expressed in normal basal cells" -other hsa-let-7b Liposarcoma 21412931 Let-7 MicroRNA and HMGA2 levels of expression are not inversely linked in adipocytic tumors: Analysis of 56 lipomas and liposarcomas with molecular cytogenetic data. -other hsa-let-7g Liposarcoma 21412931 Let-7 MicroRNA and HMGA2 levels of expression are not inversely linked in adipocytic tumors: Analysis of 56 lipomas and liposarcomas with molecular cytogenetic data. -other hsa-mir-146a Lymphoma 21416002 "In addition, LMP1 can also modulate cellular gene expression programs by affecting, via the NF-¦ÊB pathway, levels of cellular microRNAs miR-146a and miR-155" -other hsa-mir-155 Lymphoma 21416002 "In addition, LMP1 can also modulate cellular gene expression programs by affecting, via the NF-¦ÊB pathway, levels of cellular microRNAs miR-146a and miR-155" -other hsa-mir-193a Esophageal Neoplasms 21420070 The expression of three miRNAs (miR-99b and miR-199a_3p and _5p) was associated with the presence of lymph node metastasis. -other hsa-mir-99b Esophageal Neoplasms 21420070 The expression of three miRNAs (miR-99b and miR-199a_3p and _5p) was associated with the presence of lymph node metastasis. -other hsa-mir-34a Ovarian Neoplasms 21423204 We propose that elevated TRP53 and miR-34a-c may exert negatively regulatory effects that reduce the proliferative potential of OSE cells leading to the low-grade serous adenocarcinoma phenotype. -other hsa-mir-21 "Squamous Cell Carcinoma, Tongue" 21426775 Anti-sense miRNA-21 oligonucleotide inhibits Tb 3.1 human tongue squamous cell carcinoma growth in vitro.] -other hsa-mir-143 Osteosarcoma 21427707 MicroRNA-143 Regulates Human Osteosarcoma Metastasis by Regulating Matrix Metalloprotease-13 Expression. -other hsa-mir-101-1 Prostate Neoplasms 21430074 Enforced Expression of miR-101 inhibits prostate cancer cell growth by modulating cyclooxygenase-2 pathway in vivo. -other hsa-mir-101-2 Prostate Neoplasms 21430074 Enforced Expression of miR-101 inhibits prostate cancer cell growth by modulating cyclooxygenase-2 pathway in vivo. -other hsa-mir-200c Prostate Neoplasms 21431706 Differentially expressed between androgen-dependent and androgen-independent metastatic prostate cancer cells -other hsa-mir-205 Prostate Neoplasms 21431706 Differentially expressed between androgen-dependent and androgen-independent metastatic prostate cancer cells -other hsa-mir-211 Melanoma 21435193 Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor. -other hsa-mir-381 Glioblastoma 21435336 Interaction of hsa-miR-381 and glioma suppressor LRRC4 is involved in glioma growth. -other hsa-let-7a Human Papilloma Virus Infection 21442230 "HPV-38 was predicted to express an miRNA conserved to human let-7a and the expression of let-7a, in HPV-38-positive non-melanoma skin cancer (NMSC) biopsies was 10-fold higher than those with HPV-positive (for other types except HPV-38) and HPV-negative NMSCs, suggesting that let-7a expression might be related to HPV-38 infection." -other hsa-mir-328 "Carcinoma, Lung, Non-Small-Cell" 21448905 MicroRNA-328 is associated with (non-small) cell lung cancer (NSCLC) brain metastasis and mediates NSCLC migration. -other hsa-mir-10 "Leukemia, Myeloid" 21455993 Our analysis identified a strong positive correlation between HOX-related genes and miR-10 and miR-20a. -other hsa-mir-128a Leukemia 21455993 "we observed a negative correlation between miR-181a and miR-181b, miR-155, and miR-146 expression with that of genes involved in immunity and inflammation (eg, IRF7 and TLR4) and a positive correlation between miR-23a, miR-26a, miR-128a, and miR-145 expression with that of proapoptotic genes (eg, BIM and PTEN)" -other hsa-mir-145 Leukemia 21455993 "we observed a negative correlation between miR-181a and miR-181b, miR-155, and miR-146 expression with that of genes involved in immunity and inflammation (eg, IRF7 and TLR4) and a positive correlation between miR-23a, miR-26a, miR-128a, and miR-145 expression with that of proapoptotic genes (eg, BIM and PTEN)" -other hsa-mir-146 Leukemia 21455993 "we observed a negative correlation between miR-181a and miR-181b, miR-155, and miR-146 expression with that of genes involved in immunity and inflammation (eg, IRF7 and TLR4) and a positive correlation between miR-23a, miR-26a, miR-128a, and miR-145 expression with that of proapoptotic genes (eg, BIM and PTEN)" -other hsa-mir-155 Leukemia 21455993 "we observed a negative correlation between miR-181a and miR-181b, miR-155, and miR-146 expression with that of genes involved in immunity and inflammation (eg, IRF7 and TLR4) and a positive correlation between miR-23a, miR-26a, miR-128a, and miR-145 expression with that of proapoptotic genes (eg, BIM and PTEN)" -other hsa-mir-181a Leukemia 21455993 "we observed a negative correlation between miR-181a and miR-181b, miR-155, and miR-146 expression with that of genes involved in immunity and inflammation (eg, IRF7 and TLR4) and a positive correlation between miR-23a, miR-26a, miR-128a, and miR-145 expression with that of proapoptotic genes (eg, BIM and PTEN)" -other hsa-mir-181b Leukemia 21455993 "we observed a negative correlation between miR-181a and miR-181b, miR-155, and miR-146 expression with that of genes involved in immunity and inflammation (eg, IRF7 and TLR4) and a positive correlation between miR-23a, miR-26a, miR-128a, and miR-145 expression with that of proapoptotic genes (eg, BIM and PTEN)" -other hsa-mir-20a "Leukemia, Myeloid" 21455993 Our analysis identified a strong positive correlation between HOX-related genes and miR-10 and miR-20a. -other hsa-mir-23a Leukemia 21455993 "we observed a negative correlation between miR-181a and miR-181b, miR-155, and miR-146 expression with that of genes involved in immunity and inflammation (eg, IRF7 and TLR4) and a positive correlation between miR-23a, miR-26a, miR-128a, and miR-145 expression with that of proapoptotic genes (eg, BIM and PTEN)" -other hsa-mir-26a Leukemia 21455993 "we observed a negative correlation between miR-181a and miR-181b, miR-155, and miR-146 expression with that of genes involved in immunity and inflammation (eg, IRF7 and TLR4) and a positive correlation between miR-23a, miR-26a, miR-128a, and miR-145 expression with that of proapoptotic genes (eg, BIM and PTEN)" -other hsa-mir-155 Breast Neoplasms 21460854 miR-155 promotes macroscopic tumor formation yet inhibits tumor dissemination from mammary fat pads to the lung by preventing EMT. -other hsa-mir-1 "Cardiomyopathy, Hypertrophic" 21464712 "The cardiac-enriched miRNAs, including miR-1, miR-133, and miR-208, as well as the ubiquitous miR-23a and miR-199b, play major roles in the development of cardiac hypertrophy." -other hsa-mir-133 "Cardiomyopathy, Hypertrophic" 21464712 "The cardiac-enriched miRNAs, including miR-1, miR-133, and miR-208, as well as the ubiquitous miR-23a and miR-199b, play major roles in the development of cardiac hypertrophy." -other hsa-mir-199a Ischemic Diseases [unspecific] 21464712 "On the other hand, miR-21, miR-199a, miR-210, and miR-494 have been proven critical for the myocytes' adaptation and survival during hypoxia/ischemia." -other hsa-mir-199b "Cardiomyopathy, Hypertrophic" 21464712 "The cardiac-enriched miRNAs, including miR-1, miR-133, and miR-208, as well as the ubiquitous miR-23a and miR-199b, play major roles in the development of cardiac hypertrophy." -other hsa-mir-208 "Cardiomyopathy, Hypertrophic" 21464712 "The cardiac-enriched miRNAs, including miR-1, miR-133, and miR-208, as well as the ubiquitous miR-23a and miR-199b, play major roles in the development of cardiac hypertrophy." -other hsa-mir-21 Ischemic Diseases [unspecific] 21464712 "On the other hand, miR-21, miR-199a, miR-210, and miR-494 have been proven critical for the myocytes' adaptation and survival during hypoxia/ischemia." -other hsa-mir-210 Ischemic Diseases [unspecific] 21464712 "On the other hand, miR-21, miR-199a, miR-210, and miR-494 have been proven critical for the myocytes' adaptation and survival during hypoxia/ischemia." -other hsa-mir-23a "Cardiomyopathy, Hypertrophic" 21464712 "The cardiac-enriched miRNAs, including miR-1, miR-133, and miR-208, as well as the ubiquitous miR-23a and miR-199b, play major roles in the development of cardiac hypertrophy." -other hsa-mir-494 Ischemic Diseases [unspecific] 21464712 "On the other hand, miR-21, miR-199a, miR-210, and miR-494 have been proven critical for the myocytes' adaptation and survival during hypoxia/ischemia." -other hsa-mir-210 Inflammation 21467158 miRNA-210 is a good example in this category that impairs wound closure. -other hsa-mir-21 Urinary Bladder Cancer 21468550 microRNA-21 modulates cell proliferation and sensitivity to doxorubicin in bladder cancer cells -other hsa-mir-21 Breast Neoplasms 21471222 Upregulation of MIR-21 mediates resistance to trastuzumab therapy for breast cancer. -other hsa-mir-10b Glioblastoma 21471404 Human glioma growth is controlled by microRNA-10b -other hsa-mir-146a "Carcinoma, Renal Cell" 21472233 "Carbamylated albumin stimulates microRNA-146, which is increased in human renal cell carcinoma." -other hsa-mir-146b "Carcinoma, Renal Cell" 21472233 "Carbamylated albumin stimulates microRNA-146, which is increased in human renal cell carcinoma." -other hsa-let-7g Lung Neoplasms 21472347 Precursor let-7g microRNA can supress A549 lung cancer cell migration. -other hsa-mir-146a Breast Neoplasms 21472990 Down-regulation of BRCA1 expression by miR-146a and miR-146b-5p in triple negative sporadic breast cancers. -other hsa-mir-146b Breast Neoplasms 21472990 Down-regulation of BRCA1 expression by miR-146a and miR-146b-5p in triple negative sporadic breast cancers. -other hsa-mir-517a Urinary Bladder Cancer 21479368 Restoration of miR-517a expression induces cell apoptosis in bladder cancer cell lines. -other hsa-mir-221 Neoplasms [unspecific] 21481725 miRNA-221/-222 control radiation sensitivity by regulating the PTEN/AKT pathway and can be explored as novel targets for radiosensitization. -other hsa-mir-222 Neoplasms [unspecific] 21481725 miRNA-221/-222 control radiation sensitivity by regulating the PTEN/AKT pathway and can be explored as novel targets for radiosensitization. -other hsa-mir-503 "Carcinoma, Hepatocellular" 21495032 microRNA-503 regulates metastatic function in hepatocellular cancer cell. -other hsa-mir-22 Neoplasms [unspecific] 21502362 miR-22 represses cancer progression by inducing cellular senescence. -other hsa-mir-150 Lymphoma 21502955 microRNA-150 is a tumor suppressor in malignant lymphoma -other hsa-mir-183 Lung Neoplasms 21503569 microRNA-182 inhibits the proliferation and invasion of human lung adenocarcinoma cells through its effect on human cortical actin-associated protein. -other hsa-mir-192 Retinoblastoma 21511813 MicroRNA-192 targeting retinoblastoma 1 inhibits cell proliferation and induces cell apoptosis in lung cancer cells. -other hsa-mir-193b Breast Neoplasms 21512034 "we present here a proteomic screen to identify targets of miR-193b, and a systems biological approach to mimic its effects at the level of cellular phenotypes." -other hsa-mir-1-1 Hepatitis B Virus Infection 21520166 "MiR-1 regulates the expression of several host genes to enhance HBV replication and reverse cancer cell phenotype, which is apparently beneficial for HBV replication." -other hsa-mir-1-2 Hepatitis B Virus Infection 21520166 "MiR-1 regulates the expression of several host genes to enhance HBV replication and reverse cancer cell phenotype, which is apparently beneficial for HBV replication." -other hsa-mir-181a Lymphoma 21525173 "A multivariate Cox regression analysis including the IPI, the 6-gene model-derived mortality predictor score and expression of the miR-18a, miR-181a, and miR-222, revealed that all variables were independent predictors of survival except the expression of miR-222 for OS and the expression of miR-18a for PFS." -other hsa-mir-18a Lymphoma 21525173 "A multivariate Cox regression analysis including the IPI, the 6-gene model-derived mortality predictor score and expression of the miR-18a, miR-181a, and miR-222, revealed that all variables were independent predictors of survival except the expression of miR-222 for OS and the expression of miR-18a for PFS." -other hsa-mir-222 Lymphoma 21525173 "A multivariate Cox regression analysis including the IPI, the 6-gene model-derived mortality predictor score and expression of the miR-18a, miR-181a, and miR-222, revealed that all variables were independent predictors of survival except the expression of miR-222 for OS and the expression of miR-18a for PFS." -other hsa-mir-15a Multiple Myeloma 21534877 Bone marrow stromal cells protect myeloma cells from bortezomib induced apoptosis by suppressing microRNA-15a expression. -other hsa-mir-16-1 Prostate Neoplasms 21539977 "We observed correlations with clinical-pathologic parameters: miR-16, miR-195, and miR-26a were significantly correlated with surgical margin positivity; miR-195 and miR-let7i were significantly correlated with the Gleason score." -other hsa-mir-16-2 Prostate Neoplasms 21539977 "We observed correlations with clinical-pathologic parameters: miR-16, miR-195, and miR-26a were significantly correlated with surgical margin positivity; miR-195 and miR-let7i were significantly correlated with the Gleason score." -other hsa-mir-195 Prostate Neoplasms 21539977 "We observed correlations with clinical-pathologic parameters: miR-16, miR-195, and miR-26a were significantly correlated with surgical margin positivity; miR-195 and miR-let7i were significantly correlated with the Gleason score." -other hsa-mir-26a-1 Prostate Neoplasms 21539977 "We observed correlations with clinical-pathologic parameters: miR-16, miR-195, and miR-26a were significantly correlated with surgical margin positivity; miR-195 and miR-let7i were significantly correlated with the Gleason score." -other hsa-mir-26a-2 Prostate Neoplasms 21539977 "We observed correlations with clinical-pathologic parameters: miR-16, miR-195, and miR-26a were significantly correlated with surgical margin positivity; miR-195 and miR-let7i were significantly correlated with the Gleason score." -other hsa-mir-155 Nasopharyngeal Neoplasms 21541331 Upregulation of MiR-155 in Nasopharyngeal Carcinoma is Partly Driven by LMP1 and LMP2A and Downregulates a Negative Prognostic Marker JMJD1A. -other hsa-mir-34a Melanoma 21541354 miR-34a and miR-185 were further shown to inhibit the growth of melanoma xenografts when implanted in SCID-NOD mice. -other hsa-mir-142 Melanoma 21543894 "miR-142-3p, miR-486, miR-214, miR-218, miR-362, miR-650 and miR-31, were significantly correlated with acral as compared to non-acral melanomas (p < 0.04)." -other hsa-mir-214 Melanoma 21543894 "miR-142-3p, miR-486, miR-214, miR-218, miR-362, miR-650 and miR-31, were significantly correlated with acral as compared to non-acral melanomas (p < 0.04)." -other hsa-mir-218-1 Melanoma 21543894 "miR-142-3p, miR-486, miR-214, miR-218, miR-362, miR-650 and miR-31, were significantly correlated with acral as compared to non-acral melanomas (p < 0.04)." -other hsa-mir-218-2 Melanoma 21543894 "miR-142-3p, miR-486, miR-214, miR-218, miR-362, miR-650 and miR-31, were significantly correlated with acral as compared to non-acral melanomas (p < 0.04)." -other hsa-mir-31 Melanoma 21543894 "miR-142-3p, miR-486, miR-214, miR-218, miR-362, miR-650 and miR-31, were significantly correlated with acral as compared to non-acral melanomas (p < 0.04)." -other hsa-mir-362 Melanoma 21543894 "miR-142-3p, miR-486, miR-214, miR-218, miR-362, miR-650 and miR-31, were significantly correlated with acral as compared to non-acral melanomas (p < 0.04)." -other hsa-mir-486 Melanoma 21543894 "miR-142-3p, miR-486, miR-214, miR-218, miR-362, miR-650 and miR-31, were significantly correlated with acral as compared to non-acral melanomas (p < 0.04)." -other hsa-mir-650 Melanoma 21543894 "miR-142-3p, miR-486, miR-214, miR-218, miR-362, miR-650 and miR-31, were significantly correlated with acral as compared to non-acral melanomas (p < 0.04)." -other hsa-let-7d Prostate Neoplasms 21548940 PBX3 is up-regulated in prostate cancer and post- transcriptionally regulated by androgen through Let-7d. -other hsa-mir-143 Urinary Bladder Cancer 21550168 MicroRNA-143 functions as a tumor suppressor in human bladder cancer T24 cells -other hsa-mir-135a-1 "Carcinoma, Lung, Non-Small-Cell" 21552288 miR-135a contributes to paclitaxel resistance in tumor cells both in vitro and in vivo. -other hsa-mir-135a-2 "Carcinoma, Lung, Non-Small-Cell" 21552288 miR-135a contributes to paclitaxel resistance in tumor cells both in vitro and in vivo. -other hsa-mir-200c Breast Neoplasms 21553120 "Suppression of miR-200c, miR-203, and miR-205 and increases in miR-222 and miR-221 are involved in the inducement of EMT and repression of the estrogen receptor." -other hsa-mir-203 Breast Neoplasms 21553120 "Suppression of miR-200c, miR-203, and miR-205 and increases in miR-222 and miR-221 are involved in the inducement of EMT and repression of the estrogen receptor." -other hsa-mir-205 Breast Neoplasms 21553120 "Suppression of miR-200c, miR-203, and miR-205 and increases in miR-222 and miR-221 are involved in the inducement of EMT and repression of the estrogen receptor." -other hsa-mir-221 Breast Neoplasms 21553120 "Suppression of miR-200c, miR-203, and miR-205 and increases in miR-222 and miR-221 are involved in the inducement of EMT and repression of the estrogen receptor." -other hsa-mir-222 Breast Neoplasms 21553120 "Suppression of miR-200c, miR-203, and miR-205 and increases in miR-222 and miR-221 are involved in the inducement of EMT and repression of the estrogen receptor." -other hsa-mir-146a Neoplasms [unspecific] 21555486 "miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice." -other hsa-mir-143 Rectal Neoplasms 21567082 Altered levels of the onco-microRNA 21 and the tumor-supressor microRNAs 143 and 145 in advanced rectal cancer indicate successful neoadjuvant chemoradiotherapy. -other hsa-mir-145 Rectal Neoplasms 21567082 Altered levels of the onco-microRNA 21 and the tumor-supressor microRNAs 143 and 145 in advanced rectal cancer indicate successful neoadjuvant chemoradiotherapy. -other hsa-mir-21 Rectal Neoplasms 21567082 Altered levels of the onco-microRNA 21 and the tumor-supressor microRNAs 143 and 145 in advanced rectal cancer indicate successful neoadjuvant chemoradiotherapy. -other hsa-mir-27a Gastric Neoplasms 21569481 Down-regulation of miR-27a might inhibit proliferation and drug resistance of gastric cancer cells. -other hsa-mir-92a-1 Neuroblastoma 21572098 MYCN-regulated miRNA-92 Inhibits Secretion of the Tumor Suppressor DICKKOPF-3 (DKK3) in Neuroblastoma. -other hsa-mir-92a-2 Neuroblastoma 21572098 MYCN-regulated miRNA-92 Inhibits Secretion of the Tumor Suppressor DICKKOPF-3 (DKK3) in Neuroblastoma. -other hsa-mir-92b Neuroblastoma 21572098 MYCN-regulated miRNA-92 Inhibits Secretion of the Tumor Suppressor DICKKOPF-3 (DKK3) in Neuroblastoma. -other hsa-mir-15a "Carcinoma, Lung, Non-Small-Cell" 21575235 miR-34a and miR-15a/16 are co-regulated in non-small cell lung cancer and control cell cycle progression in a synergistic and Rb-dependent manner. -other hsa-mir-16-1 "Carcinoma, Lung, Non-Small-Cell" 21575235 miR-34a and miR-15a/16 are co-regulated in non-small cell lung cancer and control cell cycle progression in a synergistic and Rb-dependent manner. -other hsa-mir-16-2 "Carcinoma, Lung, Non-Small-Cell" 21575235 miR-34a and miR-15a/16 are co-regulated in non-small cell lung cancer and control cell cycle progression in a synergistic and Rb-dependent manner. -other hsa-mir-34a "Carcinoma, Lung, Non-Small-Cell" 21575235 miR-34a and miR-15a/16 are co-regulated in non-small cell lung cancer and control cell cycle progression in a synergistic and Rb-dependent manner. -other hsa-mir-133a "Cardiomyopathy, Hypertrophic" 21586423 "Logistic regression analysis identified microRNA-133a as a significant positive predictor of LVM normalisation, whereas ¦Â-myosin heavy chain and BMI constituted negative predictors." -other hsa-mir-146a Ovarian Neoplasms 21591024 "In conclusion, the polymorphism in the miR-146a gene is unlikely to be of substantial significance regarding breast cancer risk." -other hsa-mir-335 Astrocytoma 21592405 Targeting oncogenic miR-335 inhibits growth and invasion of malignant astrocytoma cells. -other hsa-mir-7-1 Neoplasms [unspecific] 21592959 USP18 regulates EGF receptor expression and cancer cell survival via microrna-7. -other hsa-mir-7-2 Neoplasms [unspecific] 21592959 USP18 regulates EGF receptor expression and cancer cell survival via microrna-7. -other hsa-mir-7-3 Neoplasms [unspecific] 21592959 USP18 regulates EGF receptor expression and cancer cell survival via microrna-7. -other hsa-mir-214 Melanoma 21593728 miR-214 drives melanoma metastasis. -other hsa-mir-29a Hepatitis C Virus Infection 21606534 Hepatitis C Virus Infection and Hepatic Stellate Cell Activation Downregulate miR-29: miR-29 Overexpression Reduces Hepatitis C Viral Abundance in Culture. -other hsa-mir-29b-1 Hepatitis C Virus Infection 21606534 Hepatitis C Virus Infection and Hepatic Stellate Cell Activation Downregulate miR-29: miR-29 Overexpression Reduces Hepatitis C Viral Abundance in Culture. -other hsa-mir-29b-2 Hepatitis C Virus Infection 21606534 Hepatitis C Virus Infection and Hepatic Stellate Cell Activation Downregulate miR-29: miR-29 Overexpression Reduces Hepatitis C Viral Abundance in Culture. -other hsa-mir-29c Hepatitis C Virus Infection 21606534 Hepatitis C Virus Infection and Hepatic Stellate Cell Activation Downregulate miR-29: miR-29 Overexpression Reduces Hepatitis C Viral Abundance in Culture. -other hsa-mir-26a-1 "Carcinoma, Hepatocellular" 21610700 Tumor-specific Expression of MicroRNA-26a Suppresses Human Hepatocellular Carcinoma Growth via Cyclin-dependent and -independent Pathways. -other hsa-mir-26a-2 "Carcinoma, Hepatocellular" 21610700 Tumor-specific Expression of MicroRNA-26a Suppresses Human Hepatocellular Carcinoma Growth via Cyclin-dependent and -independent Pathways. -other hsa-mir-346 Rheumatoid Arthritis 21611196 miR-346 Controls Release of TNF-a Protein and Stability of Its mRNA in Rheumatoid Arthritis via Tristetraprolin Stabilization. -other hsa-mir-21 Diabetes Mellitus 21613227 microRNA-21 orchestrates high glucose-induced signals to TORC1 for renal cell pathology in diabetes. -other hsa-mir-21 Glioblastoma 21618027 A miR-21 inhibitor enhances apoptosis and reduces G(2)-M accumulation induced by ionizing radiation in human glioblastoma U251 cells. -other hsa-let-7 Ovarian Neoplasms 21618519 Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1. -other hsa-mir-183 Congenital Deafness 21621863 The quantitative real-time polymerase chain reaction result demonstrated that the miR-183 family exhibits cell-specific expression in cochlear progenitor cells compared with neural stem cells. -other hsa-mir-34a Pancreatic Neoplasms 21622730 "Two miRNA candidates known to be downregulated in the majority of pancreatic cancers were selected for nanovector delivery: miR-34a, which is a component of the p53 transcriptional network and regulates cancer stem cell survival, and the miR-143/145 cluster, which together repress the expression of KRAS2 and its downstream effector Ras-responsive element binding protein-1 (RREB1)." -other hsa-mir-22 Colorectal Carcinoma 21629773 MicroRNA-22 regulates hypoxia signaling in colon cancer cells. -other hsa-mir-1246 Down Syndrome 21637297 p53 downregulates Down syndrome-associated DYRK1A through miR-1246. -other hsa-mir-130a "Leukemia, Myeloid" 21638198 MicroRNAs 130a/b are regulated by BCR-ABL and downregulate expression of CCN3 in CML (Chronic Myeloid Leukaemia). -other hsa-mir-130b "Leukemia, Myeloid" 21638198 MicroRNAs 130a/b are regulated by BCR-ABL and downregulate expression of CCN3 in CML (Chronic Myeloid Leukaemia). -other hsa-mir-21 Wounds and Injuries [unspecific] 21647251 miR-21 promotes keratinocyte migration and re-epithelialization during wound healing. -other hsa-mir-143 Prostate Neoplasms 21647377 miRs-143 and -145 are associated with bone metastasis of prostate cancer and involved in the regulation of EMT. -other hsa-mir-145 Prostate Neoplasms 21647377 miRs-143 and -145 are associated with bone metastasis of prostate cancer and involved in the regulation of EMT. -other hsa-mir-10b Pancreatic Neoplasms 21652542 microRNA-10b Expression Correlates with Response to Neoadjuvant Therapy and Survival in Pancreatic Ductal Adenocarcinoma. -other hsa-mir-122 Hepatitis C Virus Infection 21653556 miR-122 activates hepatitis C virus translation by a specialized mechanism requiring particular RNA components. -other hsa-mir-143 Colon Neoplasms 21653642 "EGFR suppresses miR-143 and miR-145 in murine models of colon cancer. Furthermore, Western diet unmasks the tumor suppressor roles of these EGFR-regulated miRNAs." -other hsa-mir-145 Colon Neoplasms 21653642 "EGFR suppresses miR-143 and miR-145 in murine models of colon cancer. Furthermore, Western diet unmasks the tumor suppressor roles of these EGFR-regulated miRNAs." -other hsa-mir-103a-1 "Diabetes Mellitus, Type 2" 21654750 MicroRNAs 103 and 107 regulate insulin sensitivity. -other hsa-mir-103a-2 "Diabetes Mellitus, Type 2" 21654750 MicroRNAs 103 and 107 regulate insulin sensitivity. -other hsa-mir-17 Multiple Myeloma 21664042 miR-17-92 cluster microRNAs confers tumorigenicity in multiple myeloma. -other hsa-mir-18a Multiple Myeloma 21664042 miR-17-92 cluster microRNAs confers tumorigenicity in multiple myeloma. -other hsa-mir-19a Multiple Myeloma 21664042 miR-17-92 cluster microRNAs confers tumorigenicity in multiple myeloma. -other hsa-mir-19b-1 Multiple Myeloma 21664042 miR-17-92 cluster microRNAs confers tumorigenicity in multiple myeloma. -other hsa-mir-20a Multiple Myeloma 21664042 miR-17-92 cluster microRNAs confers tumorigenicity in multiple myeloma. -other hsa-mir-92a-1 Multiple Myeloma 21664042 miR-17-92 cluster microRNAs confers tumorigenicity in multiple myeloma. -other hsa-mir-483 Wounds and Injuries [unspecific] 21676945 miR-483-3p controls proliferation in wounded epithelial cells. -other hsa-mir-429 Gastric Neoplasms 21684154 miR-429 Modulates the expression of c-myc in human gastric carcinoma cells. -other hsa-mir-21 "Squamous Cell Carcinoma, Head and Neck" 21685938 Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells. -other hsa-mir-143 Liposarcoma 21693658 microRNA-143 is a tumor suppressor activity in liposarcoma -other hsa-mir-34a Urinary Bladder Cancer 21702042 MiR-34a chemo-sensitizes bladder cancer cells to cisplatin treatment regardless of P53-Rb pathway status. -other hsa-mir-125b-1 "Carcinoma, Hepatocellular" 21703189 microRNA-125b regulates of placenta growth factor in hepatocellular cancer -other hsa-mir-125b-2 "Carcinoma, Hepatocellular" 21703189 microRNA-125b regulates of placenta growth factor in hepatocellular cancer -other hsa-mir-519d Prostate Neoplasms 21703393 "miR-519d,and miR-647 could be used to separate patients with and without biochemical recurrence" -other hsa-mir-647 Prostate Neoplasms 21703393 "miR-519d,and miR-647 could be used to separate patients with and without biochemical recurrence" -other hsa-mir-378a Myelodysplastic Syndromes 21703983 "hsa-mir-378, hsa-miR-632, and hsa-miR-636 demonstrated particularly high discrimination between MDS and normal controls." -other hsa-mir-632 Myelodysplastic Syndromes 21703983 "hsa-mir-378, hsa-miR-632, and hsa-miR-636 demonstrated particularly high discrimination between MDS and normal controls." -other hsa-mir-636 Myelodysplastic Syndromes 21703983 "hsa-mir-378, hsa-miR-632, and hsa-miR-636 demonstrated particularly high discrimination between MDS and normal controls." -other hsa-mir-130a "Carcinoma, Hepatocellular" 21712254 The hepatitis B virus-associated estrogen receptor alpha (ER{alpha}) was regulated by microRNA-130a in HepG2.2.15 human hepatocellular carcinoma cells. -other hsa-mir-21 Cardiovascular Diseases [unspecific] 21712654 "The small regulatory RNA microRNA-21 (miR-21) plays a crucial role in a plethora of biological functions and diseases including development, cancer, cardiovascular diseases and inflammation." -other hsa-mir-21 Multiple Myeloma 21718132 Myeloma cell adhesion to bone marrow stromal cells confers drug resistance by microRNA-21 up-regulation. -other hsa-let-7b Colorectal Carcinoma 21722265 The miRNA has a role in colorectal liver metastases. -other hsa-mir-1275 Colorectal Carcinoma 21722265 The miRNA has a role in colorectal liver metastases. -other hsa-mir-143 Colorectal Carcinoma 21722265 The miRNA has a role in colorectal liver metastases. -other hsa-mir-145 Colorectal Carcinoma 21722265 The miRNA has a role in colorectal liver metastases. -other hsa-mir-194-1 Colorectal Carcinoma 21722265 The miRNA has a role in colorectal liver metastases. -other hsa-mir-194-2 Colorectal Carcinoma 21722265 The miRNA has a role in colorectal liver metastases. -other hsa-mir-19b-1 Colorectal Carcinoma 21722265 The miRNA has a role in colorectal liver metastases. -other hsa-mir-19b-2 Colorectal Carcinoma 21722265 The miRNA has a role in colorectal liver metastases. -other hsa-mir-638 Colorectal Carcinoma 21722265 The miRNA has a role in colorectal liver metastases. -other hsa-mir-375 Melanoma 21723283 "Ectopic expression of miR-375 inhibited melanoma cell proliferation, invasion, and cell motility, and induced cell shape changes, strongly suggesting that miR-375 may have an important function in the development and progression of human melanomas." -other hsa-mir-141 Prostate Neoplasms 21723797 miR-141 demonstrated high correlation with changes of the other biomarkers. -other hsa-let-7d "Squamous Cell Carcinoma, Oral" 21725603 Let-7d functions as novel regulator of epithelial-mesenchymal transition and chemoresistant property in oral cancer. -other hsa-mir-141 Choriocarcinoma 21726338 Reduction in miR-141 is induced by leukemia inhibitory factor and inhibits proliferation in choriocarcinoma cell line JEG-3. -other hsa-mir-125b "Leukemia-Lymphoma, Precursor B-Cell Lymphoblastic" 21738213 Our results provide direct evidence that miR-125b has important roles in the tumorigenesis of precursor B cells. -other hsa-mir-210 Breast Neoplasms 21738599 "MiR-210 associated with tumor proliferation, invasion and poor clinical outcome in breast cancer." -other hsa-let-7i Immune System Disease [unspecific] 21742974 Dynamic regulation of let-7i may fine-tune immune responses by inducing Ag-specific immune tolerance. -other hsa-mir-1286 Esophageal Neoplasms 21743970 "Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy." -other hsa-mir-199a-1 Esophageal Neoplasms 21743970 "Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy." -other hsa-mir-199a-2 Esophageal Neoplasms 21743970 "Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy." -other hsa-mir-302a Esophageal Neoplasms 21743970 "Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy." -other hsa-mir-302f Esophageal Neoplasms 21743970 "Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy." -other hsa-mir-342 Esophageal Neoplasms 21743970 "Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy." -other hsa-mir-425 Esophageal Neoplasms 21743970 "Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy." -other hsa-mir-455 Esophageal Neoplasms 21743970 "Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy." -other hsa-mir-486 Esophageal Neoplasms 21743970 "Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy." -other hsa-mir-519c Esophageal Neoplasms 21743970 "Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy." -other hsa-mir-548d-1 Esophageal Neoplasms 21743970 "Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy." -other hsa-mir-548d-2 Esophageal Neoplasms 21743970 "Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy." -other hsa-mir-617 Esophageal Neoplasms 21743970 "Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy." -other hsa-mir-758 Esophageal Neoplasms 21743970 "Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy." -other hsa-mir-766 Esophageal Neoplasms 21743970 "Thirteen miRNAs (miR-199a-5p, miR-302f, miR-320a, miR-342-3p, miR-425, miR-455-3p, miR-486-3p, miR-519c-5p, miR-548d-5p, miR-617, miR-758, miR-766, miR-1286) were deregulated after 24- and/or 72-h treatment by Chemotherapy." -other hsa-mir-22 "Carcinoma, Hepatocellular" 21750200 miR-22 promotes HBV related hepatocellular carcinoma development in males. -other hsa-mir-103a-1 Hypertension 21753805 MicroRNA-130a Mediates Proliferation of Vascular Smooth Muscle Cells in Hypertension. -other hsa-mir-103a-2 Hypertension 21753805 MicroRNA-130a Mediates Proliferation of Vascular Smooth Muscle Cells in Hypertension. -other hsa-mir-18a Breast Neoplasms 21755340 "miR-18a expression was much higher in ERa-negative than in ERa-positive tumors (P < 0.0001), with the expression levels of miR-18a not differing in ERa-positive breast cancer as a function of ERa protein level." -other hsa-mir-18b Breast Neoplasms 21755340 "Low miR-18b expression was significantly associated with improved survival in HER2-negative breast cancer, although miR-18b expression was not correlated with ERa protein expression." -other hsa-mir-193b Breast Neoplasms 21755340 "The expression levels of miR-193b and miR-221 were significantly lower in ERa-negative than in ERa-positive tumors (P = 0.0015 and P = 0.0045, respectively), and the levels of these miRNAs gradually increased as ERa protein expression increased." -other hsa-mir-221 Breast Neoplasms 21755340 "The expression levels of miR-193b and miR-221 were significantly lower in ERa-negative than in ERa-positive tumors (P = 0.0015 and P = 0.0045, respectively), and the levels of these miRNAs gradually increased as ERa protein expression increased." -other hsa-mir-542 Neoplasms [unspecific] 21756784 "miR-542-3p affects carcinogenesis induced by anti-benzo(a) pyrene-7,8-diol-9,10-epoxide" -other hsa-mir-130b Multiple Myeloma 21761344 "miR-130b, miR-181a, and miR-636 to be differentially expressed between GC-sensitive and GC-resistant MM.1 cell lines." -other hsa-mir-181a-1 Multiple Myeloma 21761344 "miR-130b, miR-181a, and miR-636 to be differentially expressed between GC-sensitive and GC-resistant MM.1 cell lines." -other hsa-mir-181a-2 Multiple Myeloma 21761344 "miR-130b, miR-181a, and miR-636 to be differentially expressed between GC-sensitive and GC-resistant MM.1 cell lines." -other hsa-mir-636 Multiple Myeloma 21761344 "miR-130b, miR-181a, and miR-636 to be differentially expressed between GC-sensitive and GC-resistant MM.1 cell lines." -other hsa-mir-155 Lung Neoplasms 21762626 "miR-155 could significantly inhibit the growth of human lung cancer 95D cells in vitro, which might be closely related to miR-155 induced G0/G1 phase arrest." -other hsa-mir-138-1 "Squamous Cell Carcinoma, Head and Neck" 21770894 MicroRNA-138 suppresses epithelial-mesenchymal transition in squamous cell carcinoma cell lines. -other hsa-mir-138-2 "Squamous Cell Carcinoma, Head and Neck" 21770894 MicroRNA-138 suppresses epithelial-mesenchymal transition in squamous cell carcinoma cell lines. -other hsa-mir-21 Medulloblastoma 21775132 MicroRNA-21 suppression impedes medulloblastoma cell migration. -other hsa-mir-221 Pancreatic Neoplasms 21779484 The miRNA is Potentially Associated with Antiproliferative Activity of Benzyl Isothiocyanate in Pancreatic Cancer -other hsa-mir-375 Pancreatic Neoplasms 21779484 The miRNA is Potentially Associated with Antiproliferative Activity of Benzyl Isothiocyanate in Pancreatic Cancer -other hsa-mir-29a Renal Fibrosis 21784902 TGF-{beta}/Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29. -other hsa-mir-29b-1 Renal Fibrosis 21784902 TGF-{beta}/Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29. -other hsa-mir-29b-2 Renal Fibrosis 21784902 TGF-{beta}/Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29. -other hsa-mir-29c Renal Fibrosis 21784902 TGF-{beta}/Smad3 Signaling Promotes Renal Fibrosis by Inhibiting miR-29. -other hsa-mir-203 "Carcinoma, Hepatocellular" 21786180 miR-203 expression predicts outcome after liver transplantation for hepatocellular carcinoma in cirrhotic liver. -other hsa-mir-138-1 "Carcinoma, Lung, Non-Small-Cell" 21787234 miR-138 could play an important role in the development of cisplatin resistance in non-small cell lung cancer (NSCLC) -other hsa-mir-138-2 "Carcinoma, Lung, Non-Small-Cell" 21787234 miR-138 could play an important role in the development of cisplatin resistance in non-small cell lung cancer (NSCLC) -other hsa-mir-205 Breast Neoplasms 21787752 ErbB2 down-regulates microRNA-205 in breast cancer. -other hsa-mir-155 Encephalomyelitis 21788439 Silencing MicroRNA-155 Ameliorates Experimental Autoimmune Encephalomyelitis. -other hsa-mir-24-1 Myocardial Infarction 21788589 MicroRNA-24 Regulates Vascularity After Myocardial Infarction -other hsa-mir-24-2 Myocardial Infarction 21788589 MicroRNA-24 Regulates Vascularity After Myocardial Infarction -other hsa-mir-19b-1 Antiphospholipid Syndrome 21794077 Down-regulation of miR-19b and miR-20a observed in patients with SLE and SAF could contribute to increase TF expression and thus provoke the hypercoagulable state characteristic of these patients. -other hsa-mir-19b-1 Systemic Lupus Erythematosus 21794077 Down-regulation of miR-19b and miR-20a observed in patients with SLE and SAF could contribute to increase TF expression and thus provoke the hypercoagulable state characteristic of these patients. -other hsa-mir-20a Antiphospholipid Syndrome 21794077 Down-regulation of miR-19b and miR-20a observed in patients with SLE and SAF could contribute to increase TF expression and thus provoke the hypercoagulable state characteristic of these patients. -other hsa-mir-20a Systemic Lupus Erythematosus 21794077 Down-regulation of miR-19b and miR-20a observed in patients with SLE and SAF could contribute to increase TF expression and thus provoke the hypercoagulable state characteristic of these patients. -other hsa-mir-155 Acute Coronary Syndrome 21804579 The altered expression of inflammation-related microRNAs with microRNA-155 expression correlates with Th17 differentiation in patients with acute coronary syndrome. -other hsa-mir-155 Colorectal Carcinoma 21806946 "Neurotensin Signaling Activates MicroRNAs -21 and -155 and Akt, Promotes Tumor Growth in Mice, and is Increased in Human Colon Tumors." -other hsa-mir-21 Colorectal Carcinoma 21806946 "Neurotensin Signaling Activates MicroRNAs -21 and -155 and Akt, Promotes Tumor Growth in Mice, and is Increased in Human Colon Tumors." -other hsa-mir-1-1 Acute Coronary Syndrome 21806992 The miRNA was independently associated with hsTnT levels. -other hsa-mir-1-2 Acute Coronary Syndrome 21806992 The miRNA was independently associated with hsTnT levels. -other hsa-mir-133a-1 Acute Coronary Syndrome 21806992 The miRNA was independently associated with hsTnT levels. Its level was significantly associated with the risk of death in univariate and age- and gender-adjusted analyses. -other hsa-mir-133a-2 Acute Coronary Syndrome 21806992 The miRNA was independently associated with hsTnT levels. Its level was significantly associated with the risk of death in univariate and age- and gender-adjusted analyses. -other hsa-mir-133b Acute Coronary Syndrome 21806992 The miRNA was independently associated with hsTnT levels. -other hsa-mir-208b Acute Coronary Syndrome 21806992 The miRNA was independently associated with hsTnT levels. Its level was significantly associated with the risk of death in univariate and age- and gender-adjusted analyses. -other hsa-mir-637 "Carcinoma, Hepatocellular" 21809363 Primate-specific miRNA-637 inhibits tumorigenesis in hepatocellular carcinoma by disrupting stat3 signaling. -other hsa-mir-17 Retinoblastoma 21816922 miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma. -other hsa-mir-18a Retinoblastoma 21816922 miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma. -other hsa-mir-19a Retinoblastoma 21816922 miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma. -other hsa-mir-19b-1 Retinoblastoma 21816922 miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma. -other hsa-mir-20a Retinoblastoma 21816922 miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma. -other hsa-mir-92a-1 Retinoblastoma 21816922 miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma. -other hsa-mir-21 Atherosclerosis 21817107 MicroRNA-21 Regulates Vascular Smooth Muscle Cell Function via Targeting Tropomyosin 1 in Arteriosclerosis Obliterans of Lower Extremities. -other hsa-mir-101-1 Ovarian Neoplasms 21818714 MicroRNA-101 Inhibits Growth of Epithelial Ovarian Cancer by Relieving Chromatin-Mediated Transcriptional Repression of p21(waf1/cip1). -other hsa-mir-101-2 Ovarian Neoplasms 21818714 MicroRNA-101 Inhibits Growth of Epithelial Ovarian Cancer by Relieving Chromatin-Mediated Transcriptional Repression of p21(waf1/cip1). -other hsa-mir-155 Pancreatic Neoplasms 21826251 preferential expression in holoclones -other hsa-mir-21 Pancreatic Neoplasms 21826251 preferential expression in holoclones -other hsa-mir-214 Pancreatic Neoplasms 21826251 preferential expression in holoclones -other hsa-mir-221 Pancreatic Neoplasms 21826251 preferential expression in holoclones -other hsa-mir-222 Pancreatic Neoplasms 21826251 preferential expression in holoclones -other hsa-mir-155 "Lymphoma, Burkitt" 21831295 miR-93 repressed human activation induced cytidine deaminase. -other hsa-mir-93 "Lymphoma, Burkitt" 21831295 miR-93 repressed human activation induced cytidine deaminase. -other hsa-mir-203 Urinary Bladder Cancer 21836020 Curcumin modulates microRNA-203 mediated regulation of the Src-Akt axis in bladder cancer. -other hsa-mir-15a Leukemia 21838537 These data indicate that miR-15a/16-1 plays an important role in the ATRA-induced differentiation of leukemic and primary AML cells. -other hsa-mir-184 "Carcinoma, Renal Cell" 21844955 miR-184 show abnormal expression in human renal carcinoma. -other hsa-mir-194-1 Gastric Neoplasms 21845495 There is an inverse Association between miR-194 Expression and Tumor Invasion in Gastric Cancer. -other hsa-mir-194-2 Gastric Neoplasms 21845495 There is an inverse Association between miR-194 Expression and Tumor Invasion in Gastric Cancer. -other hsa-mir-874 "Squamous Cell Carcinoma, Maxillary Sinus" 21847129 Tumour suppressive microRNA-874 regulates novel cancer networks in maxillary sinus squamous cell carcinoma. -other hsa-mir-708 "Carcinoma, Renal Cell" 21852381 MicroRNA-708 induces apoptosis and suppresses tumorigenicity in renal cancer cells. -other hsa-mir-21 Renal Fibrosis 21852586 Smad3-Mediated Upregulation of miR-21 Promotes Renal Fibrosis. -other hsa-mir-126 Ischemia 21856785 MicroRNA-126 modulates endothelial SDF-1 expression and mobilization of Sca-1+/Lin- progenitor cells in ischemia. -other hsa-mir-203 "Leukemia-Lymphoma, Adult T-Cell" 21865341 repressed -other hsa-mir-205 "Leukemia-Lymphoma, Adult T-Cell" 21865341 repressed -other hsa-mir-326 "Leukemia-Lymphoma, Adult T-Cell" 21865341 induced -other hsa-mir-663a "Leukemia-Lymphoma, Adult T-Cell" 21865341 induced -other hsa-mir-711 "Leukemia-Lymphoma, Adult T-Cell" 21865341 induced -other hsa-mir-15b Influenza 21872652 Ginsenoside metabolite protopanaxatriol showed significant suppression effect on IP-10 production upon H9N2/G1 infection through up-regulation of miR-15b expression. -other hsa-mir-200c Colorectal Carcinoma 21873159 Oncogenic KRAS Regulates miR-200c and miR-221/222 in a 3D-Specific Manner in Colorectal Cancer Cells. -other hsa-mir-221 Colorectal Carcinoma 21873159 Oncogenic KRAS Regulates miR-200c and miR-221/222 in a 3D-Specific Manner in Colorectal Cancer Cells. -other hsa-mir-222 Colorectal Carcinoma 21873159 Oncogenic KRAS Regulates miR-200c and miR-221/222 in a 3D-Specific Manner in Colorectal Cancer Cells. -other hsa-mir-149 Nasopharyngeal Neoplasms 21873783 miR-149 promotes epithelial-mesenchymal transition and invasion in nasopharyngeal carcinoma cells. -other hsa-mir-128-1 Glioblastoma 21874051 Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases. -other hsa-mir-128-2 Glioblastoma 21874051 Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases. -other hsa-mir-138-1 "Carcinoma, Renal Cell" 21875287 MiR-138 Suppresses Expression of Hypoxia-inducible factor 1a (HIF-1a) in Clear Cell Renal Cell Carcinoma 786-O Cells. -other hsa-mir-138-2 "Carcinoma, Renal Cell" 21875287 MiR-138 Suppresses Expression of Hypoxia-inducible factor 1a (HIF-1a) in Clear Cell Renal Cell Carcinoma 786-O Cells. -other hsa-mir-31 Neoplasms [unspecific] 21875932 miR-31 is a master regulator of integrins. The expression of miR-31 in cancer cells resulted in a significant repression of these integrin subunits both at the mRNA and protein levels. -other hsa-mir-101-1 "Carcinoma, Hepatocellular" 21876625 potential associated miRNA -other hsa-mir-101-1 Hepatitis B Virus Infection 21876625 potential associated miRNA -other hsa-mir-101-2 "Carcinoma, Hepatocellular" 21876625 potential associated miRNA -other hsa-mir-101-2 Hepatitis B Virus Infection 21876625 potential associated miRNA -other hsa-mir-106a "Carcinoma, Hepatocellular" 21876625 potential associated miRNA -other hsa-mir-106a Hepatitis B Virus Infection 21876625 potential associated miRNA -other hsa-mir-106b "Carcinoma, Hepatocellular" 21876625 potential associated miRNA -other hsa-mir-106b Hepatitis B Virus Infection 21876625 potential associated miRNA -other hsa-mir-18a "Carcinoma, Hepatocellular" 21876625 potential associated miRNA -other hsa-mir-18a Hepatitis B Virus Infection 21876625 potential associated miRNA -other hsa-mir-18b "Carcinoma, Hepatocellular" 21876625 potential associated miRNA -other hsa-mir-18b Hepatitis B Virus Infection 21876625 potential associated miRNA -other hsa-mir-125b-1 "Leukemia, Promyelocytic, Acute" 21880154 Upregulation of microRNA-125b contributes to leukemogenesis and increases drug resistance in pediatric acute promyelocytic leukemia. -other hsa-mir-29a "Leukemia, Myeloid, Acute" 21880628 miR-29a and miR-30c might contribute to the sensitivity to cytarabine -other hsa-mir-30c-1 "Leukemia, Myeloid, Acute" 21880628 miR-29a and miR-30c might contribute to the sensitivity to cytarabine -other hsa-mir-30c-2 "Leukemia, Myeloid, Acute" 21880628 miR-29a and miR-30c might contribute to the sensitivity to cytarabine -other hsa-mir-637 Osteoporosis 21880893 "miR-637 suppressed the growth of hMSCs and induced S-phase arrest. Expression of miR-637 was increased during adipocyte differentiation (AD) whereas it was decreased during osteoblast differentiation (OS), which suggests that miR-637 could act as a mediator of adipo-osteogenic differentiation. Disruption of this differentiation balance leads to various bone-related metabolic diseases, including osteoporosis. Therefore, miR-637 could contributes to osteoporosis." -other hsa-mir-155 Atrophic Gastritis 21880981 MicroRNA-155 Is Essential for the T Cell-Mediated Control of Helicobacter pylori Infection and for the Induction of Chronic Gastritis and Colitis. -other hsa-mir-155 Colitis 21880981 MicroRNA-155 Is Essential for the T Cell-Mediated Control of Helicobacter pylori Infection and for the Induction of Chronic Gastritis and Colitis. -other hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 21881595 Systemic in vivo lentiviral delivery of miR-15a/16 reduces malignancy in the NZB de novo mouse model of chronic lymphocytic leukemia. -other hsa-mir-16 "Leukemia, Lymphocytic, Chronic, B-Cell" 21881595 Systemic in vivo lentiviral delivery of miR-15a/16 reduces malignancy in the NZB de novo mouse model of chronic lymphocytic leukemia. -other hsa-mir-92a-1 Colon Neoplasms 21883694 miR-92 is a key oncogenic component of the miR-17-92 cluster in colon cancer -other hsa-mir-204 Hypertension 21890685 "These effects were associated with the inhibition of Src, STAT3, Pim1, NFATc2, and Survivin and the upregulation of BMPR2 and miR-204." -other hsa-mir-181c Glioblastoma 21895872 Evaluation of the miR-181c in combination with miR-21 predicted time to progression within six months from diagnosis with 92% sensitivity and 81% specificity (p < 0.0001). The combination of miR-181c and miR-21 could be a very sensitive and specific test to identify patients at high risk of early progression after surgery. -other hsa-mir-195 Glioblastoma 21895872 miR-195 (P=0.0124; log-rank test) has positively correlated with overall survival. -other hsa-mir-196b Glioblastoma 21895872 miR-196b (P=0.0492; log-rank test) has positively correlated with overall survival. -other hsa-mir-21 Glioblastoma 21895872 Evaluation of the miR-181c in combination with miR-21 predicted time to progression within six months from diagnosis with 92% sensitivity and 81% specificity (p < 0.0001). The combination of miR-181c and miR-21 could be a very sensitive and specific test to identify patients at high risk of early progression after surgery. -other hsa-mir-149 Melanoma 21896753 "p53 directly up-regulates microRNA-149* (miR-149*) that in turn targets glycogen synthase kinase-3§Ø©ã resulting in increased expression of Mcl-1 and resistance to apoptosis in melanoma cells. Although deficiency in miR-149* undermined survival of melanoma cells and inhibited melanoma growth in a mouse xenograft model, elevated expression of miR-149* was found in fresh human metastatic melanoma isolates, which was associated with decreased glycogen synthase kinase-3§Ø©ãand increased Mcl-1." -other hsa-mir-17 Periodontitis 21898695 MiR-17 Modulates Osteogenic Differentiation Through a Coherent Feed-Forward Loop in Mesenchymal Stem Cells Isolated from Periodontal Ligaments of Patients With Periodontitis. -other hsa-mir-26a-1 "Leukemia, Myeloid, Acute" 21901171 Critical Role of c-Myc in Acute Myeloid Leukemia Involving Direct Regulation of miR-26a and Histone Methyltransferase EZH2. -other hsa-mir-26a-2 "Leukemia, Myeloid, Acute" 21901171 Critical Role of c-Myc in Acute Myeloid Leukemia Involving Direct Regulation of miR-26a and Histone Methyltransferase EZH2. -other hsa-mir-122 Hepatitis B Virus Infection 21902631 "Hybridization between the host-encoded, liver-specific microRNA (miR-122) and the 5'-untranslated region of HCV genome was shown to be required for effective viral RNA replication." -other hsa-mir-122 Hepatitis B Virus Infection 21903935 "miR-122 may down-regulate HBV replication by binding to the viral target sequence, contributing to the persistent/chronic infection of HBV, and that HBV-induced modulation of miR-122 expression may represent a mechanism to facilitate viral pathogenesis." -other hsa-mir-155 Multiple Sclerosis 21908875 "Expression of three neurosteroid synthesis enzyme-specific micro-RNAs (miR-338, miR-155 and miR-491) showed a bias towards induction in patients with multiple sclerosis (P < 0.05)." -other hsa-mir-338 Multiple Sclerosis 21908875 "Expression of three neurosteroid synthesis enzyme-specific micro-RNAs (miR-338, miR-155 and miR-491) showed a bias towards induction in patients with multiple sclerosis (P < 0.05)." -other hsa-mir-491 Multiple Sclerosis 21908875 "Expression of three neurosteroid synthesis enzyme-specific micro-RNAs (miR-338, miR-155 and miR-491) showed a bias towards induction in patients with multiple sclerosis (P < 0.05)." -other hsa-mir-21 Cardiovascular Diseases [unspecific] 21909994 This review highlights the complex roles that miRNA-21 plays in cancer and cardiovascular diseases and its potential clinical applications. -other hsa-mir-16-1 Pancreatic Neoplasms 21913185 miR-16 and miR-196a possessed an independent role in discriminating PCa (pancreatic cancer) from normal and CP. -other hsa-mir-16-2 Pancreatic Neoplasms 21913185 miR-16 and miR-196a possessed an independent role in discriminating PCa (pancreatic cancer) from normal and CP. -other hsa-mir-196a-1 Pancreatic Neoplasms 21913185 miR-16 and miR-196a possessed an independent role in discriminating PCa (pancreatic cancer) from normal and CP. -other hsa-mir-196a-2 Pancreatic Neoplasms 21913185 miR-16 and miR-196a possessed an independent role in discriminating PCa (pancreatic cancer) from normal and CP. -other hsa-mir-125b-1 Hailey-Hailey Disease 21913998 Oxidative stress activation of miR-125b is part of the molecular switch for Hailey-Hailey disease manifestation. -other hsa-mir-122 "Carcinoma, Hepatocellular" 21917968 HepG2 cells expressing miR-122 support the entire hepatitis C virus life cycle. -other hsa-mir-151a Anemia 21921042 Expression of miR-26b and miR-151-3p were both associated with HbF levels at MTD (maximum tolerated dose). -other hsa-mir-26b Anemia 21921042 Expression of miR-26b and miR-151-3p were both associated with HbF levels at MTD (maximum tolerated dose). -other hsa-mir-375 "Squamous Cell Carcinoma, Maxillary Sinus" 21922130 Tumor suppressive microRNA-375 regulates lactate dehydrogenase B in maxillary sinus squamous cell carcinoma. -other hsa-mir-708 "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 21926415 miR-708 was also found to be associated with the in vivo glucocorticoid therapy response and with disease risk stratification. -other hsa-mir-144 Colorectal Carcinoma 21929751 Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism. -other hsa-mir-150 Lung Neoplasms 21935578 Anti-miR-150 vector can regress A549 lung cancer tumors. -other hsa-mir-15a Multiple Myeloma 21936961 Suppressing miRNA-15a/-16 expression by interleukin-6 enhances drug-resistance in myeloma cells. -other hsa-mir-16-1 Multiple Myeloma 21936961 Suppressing miRNA-15a/-16 expression by interleukin-6 enhances drug-resistance in myeloma cells. -other hsa-mir-15b Glioma 21937590 "MiR-15b and miR-21 were differentially expressed in CSF (cerebrospinal fluid) samples from patients with gliomas, compared to control subjects with various neurologic disorders, including patients with primary CNS lymphoma and carcinomatous brain metastases.In conclusion, the results of this pilot study demonstrate that miR-15b and miR-21 are markers for gliomas, which can be assessed in the CSF by means of qRT-PCR." -other hsa-mir-21 Glioma 21937590 "MiR-15b and miR-21 were differentially expressed in CSF (cerebrospinal fluid) samples from patients with gliomas, compared to control subjects with various neurologic disorders, including patients with primary CNS lymphoma and carcinomatous brain metastases.In conclusion, the results of this pilot study demonstrate that miR-15b and miR-21 are markers for gliomas, which can be assessed in the CSF by means of qRT-PCR." -other hsa-mir-21 Melanoma 21940630 MicroRNA-21 regulates the metastatic behavior of B16 melanoma cells. -other hsa-mir-451a "Leukemia, Myeloid, Chronic" 21944890 miRNA-451 is a putative predictor marker of Imatinib therapy response in chronic myeloid leukemia. -other hsa-mir-126 Atherosclerosis 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-126 Cardiomegaly 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-126 Coronary Artery Disease 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-126 Diabetes Mellitus 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-126 Hypertension 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-155 Atherosclerosis 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-155 Cardiomegaly 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-155 Coronary Artery Disease 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-155 Diabetes Mellitus 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-155 Hypertension 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-17 Atherosclerosis 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-17 Cardiomegaly 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-17 Coronary Artery Disease 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-17 Diabetes Mellitus 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-17 Hypertension 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-221 Atherosclerosis 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-221 Cardiomegaly 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-221 Coronary Artery Disease 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-221 Diabetes Mellitus 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-221 Hypertension 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-222 Atherosclerosis 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-222 Cardiomegaly 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-222 Coronary Artery Disease 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-222 Diabetes Mellitus 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-222 Hypertension 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-31 Atherosclerosis 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-31 Cardiomegaly 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-31 Coronary Artery Disease 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-31 Diabetes Mellitus 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-31 Hypertension 21946298 "Other known miRNAs,including miR-31, miR17-3p, miR-155, miR-221, miR-222, and miR-126, are important factors in the regulation of vascular inflammation." -other hsa-mir-548d-1 Pancreatic Neoplasms 21946813 MicroRNA miR-548d Is a Superior Regulator in Pancreatic Cancer. -other hsa-mir-548d-2 Pancreatic Neoplasms 21946813 MicroRNA miR-548d Is a Superior Regulator in Pancreatic Cancer. -other hsa-mir-146a Gastric Neoplasms 21947847 H. pylori related proinflammatory cytokines contribute to the induction of miR-146a in human gastric epithelial cells. -other hsa-mir-451a Colorectal Carcinoma 21948564 "Microrna-451 is Involved in the Self-Renewal, Tumorigenicity and Chemoresistance of Colorectal Cancer Stem Cells." -other hsa-mir-126 Myocardial Infarction 21949332 "miR-223 and miR-197 showed positive associations (multivariable HR 2.19 [95% CI 1.26 to 3.83], p=0.006, and 1.79 [95% CI 1.00 to 3.20], p=0.049) while miR-126 was inversely correlated with disease risk (multivariable HR 0.40 [95% CI 0.22 to 0.73], p=0.003)." -other hsa-mir-197 Myocardial Infarction 21949332 "miR-223 and miR-197 showed positive associations (multivariable HR 2.19 [95% CI 1.26 to 3.83], p=0.006, and 1.79 [95% CI 1.00 to 3.20], p=0.049) while miR-126 was inversely correlated with disease risk (multivariable HR 0.40 [95% CI 0.22 to 0.73], p=0.003)." -other hsa-mir-223 Myocardial Infarction 21949332 "miR-223 and miR-197 showed positive associations (multivariable HR 2.19 [95% CI 1.26 to 3.83], p=0.006, and 1.79 [95% CI 1.00 to 3.20], p=0.049) while miR-126 was inversely correlated with disease risk (multivariable HR 0.40 [95% CI 0.22 to 0.73], p=0.003)." -other hsa-mir-34b Melanoma 21949788 "Expression of miR-34b reduced cell invasion and motility rates of both WM1552C and A375, suggesting that the enhanced cell invasiveness and motility observed in metastatic melanoma cells may be related to their reduced expression of miR-34b." -other hsa-mir-10a Atherosclerosis 21952822 Endothelial inflammation is critically regulated by miRNAs such as miR-126 and miR-10a in vitro and in vivo. -other hsa-mir-126 Atherosclerosis 21952822 Endothelial inflammation is critically regulated by miRNAs such as miR-126 and miR-10a in vitro and in vivo. -other hsa-mir-146a Systemic Lupus Erythematosus 21952984 miR-146a has a role in the pathogenesis of systemic lupus erythematosus with atherosclerosis. -other hsa-mir-135b Pancreatic Neoplasms 21953293 "Using relative qRT-PCR to measure miR-135b normalized to miR-24 in 75 FFPE specimens (42 PDAC and 33 CP) covering a broad range of tumor content, the authors discriminated CP from PDAC with a sensitivity and specificity of 92.9% [95%CI=(80.5,98.5)] and 93.4% [95%CI=(79.8,99.3)], respectively. Therefore, miR-135b could be a novel biomarker for pancreatic ductal adenocarcinoma." -other hsa-mir-200b Lung Neoplasms 21954225 "Stably expressing microRNA-200b in As-p53lowHBECs (human bronchial epithelial cell) abolished Akt and Erk1/2 activation, and completely suppressed cell migration and invasion." -other hsa-mir-34a Dementia 21956116 miR-34a was among the most highly induced miRNAs in HIV-1 Tat-treated neurons. -other hsa-mir-34a Ewing Sarcoma 21960059 "miR-34a and miR490-3p achieved sufficient statistical power to predict prognosis.Patients with the highest expression of miR-34a did not experience adverse events in 5 years; in contrast, patients with the lowest expression recurred within two years." -other hsa-mir-490 Ewing Sarcoma 21960059 miR-34a and miR490-3p achieved sufficient statistical power to predict prognosis. -other hsa-mir-125b-1 Glioblastoma 21961478 altered expression after Polyunsaturated fatty acids (PUFAs) treatment -other hsa-mir-125b-2 Glioblastoma 21961478 altered expression after Polyunsaturated fatty acids (PUFAs) treatment -other hsa-mir-143 Glioblastoma 21961478 altered expression after Polyunsaturated fatty acids (PUFAs) treatment -other hsa-mir-145 Glioblastoma 21961478 altered expression after Polyunsaturated fatty acids (PUFAs) treatment -other hsa-mir-149 Glioblastoma 21961478 altered expression after Polyunsaturated fatty acids (PUFAs) treatment -other hsa-mir-16-1 Glioblastoma 21961478 altered expression after Polyunsaturated fatty acids (PUFAs) treatment -other hsa-mir-16-2 Glioblastoma 21961478 altered expression after Polyunsaturated fatty acids (PUFAs) treatment -other hsa-mir-17 Glioblastoma 21961478 altered expression after Polyunsaturated fatty acids (PUFAs) treatment -other hsa-mir-181a-2 Glioblastoma 21961478 altered expression after Polyunsaturated fatty acids (PUFAs) treatment -other hsa-mir-183 Glioblastoma 21961478 altered expression after Polyunsaturated fatty acids (PUFAs) treatment -other hsa-mir-206 Glioblastoma 21961478 altered expression after Polyunsaturated fatty acids (PUFAs) treatment -other hsa-mir-208a Glioblastoma 21961478 altered expression after Polyunsaturated fatty acids (PUFAs) treatment -other hsa-mir-208b Glioblastoma 21961478 altered expression after Polyunsaturated fatty acids (PUFAs) treatment -other hsa-mir-20a Glioblastoma 21961478 altered expression after Polyunsaturated fatty acids (PUFAs) treatment -other hsa-mir-20b Glioblastoma 21961478 altered expression after Polyunsaturated fatty acids (PUFAs) treatment -other hsa-mir-22 Glioblastoma 21961478 altered expression after Polyunsaturated fatty acids (PUFAs) treatment -other hsa-mir-224 Glioblastoma 21961478 altered expression after Polyunsaturated fatty acids (PUFAs) treatment -other hsa-mir-25 Glioblastoma 21961478 altered expression after Polyunsaturated fatty acids (PUFAs) treatment -other hsa-mir-26a-1 Glioblastoma 21961478 altered expression after Polyunsaturated fatty acids (PUFAs) treatment -other hsa-mir-26a-2 Glioblastoma 21961478 altered expression after Polyunsaturated fatty acids (PUFAs) treatment -other hsa-mir-29a Glioblastoma 21961478 altered expression after Polyunsaturated fatty acids (PUFAs) treatment -other hsa-mir-29c Glioblastoma 21961478 altered expression after Polyunsaturated fatty acids (PUFAs) treatment -other hsa-mir-30c-1 Glioblastoma 21961478 altered expression after Polyunsaturated fatty acids (PUFAs) treatment -other hsa-mir-30c-2 Glioblastoma 21961478 altered expression after Polyunsaturated fatty acids (PUFAs) treatment -other hsa-mir-126 Arteriosclerosis Obliterans 21969012 "Muscle-enriched miR-499 and miR-133a are released from the heart into the coronary circulation on myocardial injury, whereas the vascular miR-126 is consumed during transcoronary passage. " -other hsa-mir-133a Arteriosclerosis Obliterans 21969012 "Muscle-enriched miR-499 and miR-133a are released from the heart into the coronary circulation on myocardial injury, whereas the vascular miR-126 is consumed during transcoronary passage. " -other hsa-mir-499 Arteriosclerosis Obliterans 21969012 "Muscle-enriched miR-499 and miR-133a are released from the heart into the coronary circulation on myocardial injury, whereas the vascular miR-126 is consumed during transcoronary passage. " -other hsa-mir-142 Hepatitis C Virus Infection 21970718 "miR-128a, miR-196a and miR-142-3p were modulated in a concerted fashion in all three HCV clones" -other hsa-mir-196a-1 Hepatitis C Virus Infection 21970718 "miR-128a, miR-196a and miR-142-3p were modulated in a concerted fashion in all three HCV clones" -other hsa-mir-331 Prostate Neoplasms 21971048 The RNA-binding protein HuR opposes the repression of ERBB-2 expression by miR-331-3p in prostate cancer cells. -other hsa-mir-148a Ovarian Neoplasms 21971665 Ovarian Altered expression of miR-152 and miR-148a in ovarian cancer is related to cell proliferation. -other hsa-mir-152 Ovarian Neoplasms 21971665 Ovarian Altered expression of miR-152 and miR-148a in ovarian cancer is related to cell proliferation. -other hsa-mir-212 Heart Failure 21977024 "Conversely, alcohol-mediated inhibition of mTOR/S6K1, down-regulation of INS receptor and growth-inhibitory mir-200 family, and upregulation of mir-212 that promotes fetal gene program may exacerbate CRS-related cardiomyopathy." -other hsa-mir-146a Prostate Neoplasms 21980038 "Microdissected epithelial structures with CgA-positive cell clusters exhibited a more than 5- and 7-fold lower expression of miR-146a and miR-146b-5p than their CgA-negative counterparts. As focal basal cell layer disruptions and the reduction or loss of miR-146a and miR-146b-5p has been documented to correlate with prostate tumor invasion and hormone refractoriness, our findings suggest that aberrant CgA expression in epithelial structures with FBCLD may represent an early sign of these events." -other hsa-mir-126 Prostate Neoplasms 21980368 "miR-16, miR-34a, miR-126*, miR-145, miR-205 have been linked to prostate cancer metastasis" -other hsa-mir-145 Prostate Neoplasms 21980368 "miR-16, miR-34a, miR-126*, miR-145, miR-205 have been linked to prostate cancer metastasis" -other hsa-mir-16-1 Prostate Neoplasms 21980368 "miR-16, miR-34a, miR-126*, miR-145, miR-205 have been linked to prostate cancer metastasis" -other hsa-mir-16-2 Prostate Neoplasms 21980368 "miR-16, miR-34a, miR-126*, miR-145, miR-205 have been linked to prostate cancer metastasis" -other hsa-mir-205 Prostate Neoplasms 21980368 "miR-16, miR-34a, miR-126*, miR-145, miR-205 have been linked to prostate cancer metastasis" -other hsa-mir-34a Prostate Neoplasms 21980368 "miR-16, miR-34a, miR-126*, miR-145, miR-205 have been linked to prostate cancer metastasis" -other hsa-mir-146a "Carcinoma, Hepatocellular" 21982769 miR-146a suppresses the sensitivity to interferon-a in hepatocellular carcinoma cells. -other hsa-mir-206 "Carcinoma, Endometrioid Endometrial" 21983130 Expression of the tumor suppressor miR-206 is associated with cellular proliferative inhibition and impairs invasion in ER§Ø©ãpositive endometrioid adenocarcinoma. -other hsa-mir-205 Mesothelioma 21983934 "our findings indicate that epithelial-mesenchymal transition has a significant part in the morphological features of malignant mesothelioma. In particular, miR-205 down-regulation correlated ignificantly with both a mesenchymal phenotype and a more aggressive behavior." -other hsa-mir-15a "Lymphoma, Mantle-Cell" 22002311 Myc represses miR-15a/miR-16-1 expression through recruitment of HDAC3 in mantle cell and other non-Hodgkin B-cell lymphomas. -other hsa-mir-16-1 "Lymphoma, Mantle-Cell" 22002311 Myc represses miR-15a/miR-16-1 expression through recruitment of HDAC3 in mantle cell and other non-Hodgkin B-cell lymphomas. -other hsa-mir-181b Breast Neoplasms 22009755 "In conclusion, miR-221/222 and -181b facilitate growth factor signaling in tamoxifen-resistant breast cancer by down-regulating TIMP3, and corresponding anti-miRs can be used to render these tumors responsive to tamoxifen." -other hsa-mir-221 Breast Neoplasms 22009755 "In conclusion, miR-221/222 and -181b facilitate growth factor signaling in tamoxifen-resistant breast cancer by down-regulating TIMP3, and corresponding anti-miRs can be used to render these tumors responsive to tamoxifen." -other hsa-mir-222 Breast Neoplasms 22009755 "In conclusion, miR-221/222 and -181b facilitate growth factor signaling in tamoxifen-resistant breast cancer by down-regulating TIMP3, and corresponding anti-miRs can be used to render these tumors responsive to tamoxifen." -other hsa-mir-101-1 "Carcinoma, Lung, Non-Small-Cell" 22014955 "The endogenous miR-101 level was similar or lower in 13 NSCLC cell lines but was 11-fold higher in one cell line (H157) than in NL20 cells. Although ectopic miR-101 efficiently decreased the ATM and DNA-PKcs levels and increased the radiosensitization level in H1299, H1975, and A549 cells, it did not change the levels of the miR-101 targets or radiosensitivity in H157 cells." -other hsa-mir-101-2 "Carcinoma, Lung, Non-Small-Cell" 22014955 "The endogenous miR-101 level was similar or lower in 13 NSCLC cell lines but was 11-fold higher in one cell line (H157) than in NL20 cells. Although ectopic miR-101 efficiently decreased the ATM and DNA-PKcs levels and increased the radiosensitization level in H1299, H1975, and A549 cells, it did not change the levels of the miR-101 targets or radiosensitivity in H157 cells." -other hsa-mir-15b "Leukemia, Myeloid, Acute" 22015065 "miR-590-5p, miR-219-5p, miR-15b and miR-628-5p are commonly regulated by IL-3, GM-CSF and G-CSF in acute myeloid leukemia." -other hsa-mir-219 "Leukemia, Myeloid, Acute" 22015065 "miR-590-5p, miR-219-5p, miR-15b and miR-628-5p are commonly regulated by IL-3, GM-CSF and G-CSF in acute myeloid leukemia." -other hsa-mir-219-1 "Leukemia, Myeloid, Acute" 22015065 "miR-590-5p, miR-219-5p, miR-15b and miR-628-5p are commonly regulated by IL-3, GM-CSF and G-CSF in acute myeloid leukemia." -other hsa-mir-590 "Leukemia, Myeloid, Acute" 22015065 "miR-590-5p, miR-219-5p, miR-15b and miR-628-5p are commonly regulated by IL-3, GM-CSF and G-CSF in acute myeloid leukemia." -other hsa-mir-628 "Leukemia, Myeloid, Acute" 22015065 "miR-590-5p, miR-219-5p, miR-15b and miR-628-5p are commonly regulated by IL-3, GM-CSF and G-CSF in acute myeloid leukemia." -other hsa-mir-27a Gastric Neoplasms 22018270 miR-27 promotes human gastric cancer cell metastasis by inducing epithelial-to-mesenchymal transition. -other hsa-mir-27b Gastric Neoplasms 22018270 miR-27 promotes human gastric cancer cell metastasis by inducing epithelial-to-mesenchymal transition. -other hsa-mir-10b Breast Neoplasms 22020939 Cysteine rich 61-connective tissue growth factor-nephroblastoma-overexpressed 5 (CCN5)/Wnt-1-induced signaling protein-2(WISP-2) regulates microRNA-10b via hypoxia-inducible factor-1{alpha}-TWIST signaling networks in human breast cancer cells. -other hsa-mir-340 Coronary Artery Disease 22022480 Platelets in Patients with Premature Coronary Artery Disease Exhibit Upregulation of miRNA340* and miRNA624*. -other hsa-mir-624 Coronary Artery Disease 22022480 Platelets in Patients with Premature Coronary Artery Disease Exhibit Upregulation of miRNA340* and miRNA624*. -other hsa-mir-335 Breast Neoplasms 22034498 Aryl Hydrocarbon Receptor (AHR) Agonists Induce MicroRNA-335 Expression and Inhibit Lung Metastasis of Estrogen Receptor Negative Breast Cancer Cells. -other hsa-mir-101-1 "Carcinoma, Hepatocellular" 22035408 "Benzothiazole based compounds exhibited effective cytotoxicity at 4 M concentration and have shown G1 cell cycle arrest with decrease in levels of G1 cell cycle proteins such as cyclin D1 and Skp2. Involvement of tumour suppressor proteins such as PTEN and p53 was studied. Interestingly these compounds displayed decrease in the phosphorylated forms of AKT, p38 MAPK and ERK1/2 which play a vital role in cell proliferation. Compounds have exhibited strong and significant effect on the expression of micro RNAs such as miR-195a & miR-101-1 which regulate hepatic cell proliferation." -other hsa-mir-15b Anus Neoplasm 22045185 "The expression of miR-15b was shown to be highly correlated with that of five selected E2F-induced genes (CCNA2, CCNB1, CCNB2, MSH6 and MCM7). A knockdown of HPV16 E7 resulted in decreased levels of miR-15b in Ca Ski cells.Conclusion:MiR-15b expression correlates with E2F-regulated genes in anal carcinoma and appears to be part of the E2F-regulatory network." -other hsa-mir-200c "Carcinoma, Lung, Non-Small-Cell" 22045191 "Ectopic expression of mir-200c alters expression of EMT proteins, sensitivity to erlotinib, and migration in lung cells." -other hsa-mir-505 Breast Neoplasms 22051041 "miR-505 is a novel tumor suppressive miRNA and inhibits cell proliferation by inducing apoptosis. We also find that Akt3, correlate inversely with miR-505, modulates drug sensitivity in MCF7-ADR." -other hsa-mir-150 Colorectal Carcinoma 22052060 "Only one miR-150 was found to show a decrease in expression levels in the three tissue groups (normal, adenoma and cancer tissue) in parallel with increasing carcinogenesis of the colorectal tissue. In both ISH and qRT-PCR analysis, tumour tissue had reduced levels of miR-150 expression compared with paired non-cancerous tissue, which indicated that the levels of miR-150 expression were associated with CRC. Moreover, patients whose tumours had low miR-150 expression had shorter survival and a worse response to adjuvant chemotherapy than patients whose tumours had high miRNA expression." -other hsa-mir-378a "Carcinoma, Lung, Non-Small-Cell" 22052152 "MicroRNA-378 is associated with non-small cell lung cancer brain metastasis by promoting cell migration, invasion and tumor angiogenesis." -other hsa-mir-34b "Adenocarcinoma, Endometrial" 22052540 MicroRNA-34b functions as a potential tumor suppressor in endometrial serous adenocarcinoma. -other hsa-mir-155 Ischemia 22052914 Inhibition of miR-15 Protects Against Cardiac Ischemic Injury. -other hsa-let-7d Ependymoma 22053178 "Three miRNAs (let-7d, miR-596 and miR-367) strongly correlate to overall survival." -other hsa-mir-203 Ependymoma 22053178 miR-203 is an independent marker for relapse compared to the parameters that are currently used. -other hsa-mir-367 Ependymoma 22053178 "Three miRNAs (let-7d, miR-596 and miR-367) strongly correlate to overall survival." -other hsa-mir-596 Ependymoma 22053178 "Three miRNAs (let-7d, miR-596 and miR-367) strongly correlate to overall survival." -other hsa-mir-30d Ovarian Neoplasms 22058146 A combined array-based comparative genomic hybridization (aCGH) and functional library screening approach identifies mir-30d as an oncomir in cancer. -other hsa-mir-200a "Carcinoma, Renal Cell" 22082152 MiRNA-9 and MiRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS. -other hsa-mir-9-1 "Carcinoma, Renal Cell" 22082152 MiRNA-9 and MiRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS. -other hsa-mir-9-2 "Carcinoma, Renal Cell" 22082152 MiRNA-9 and MiRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS. -other hsa-mir-9-3 "Carcinoma, Renal Cell" 22082152 MiRNA-9 and MiRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS. -other hsa-mir-23a Hypertrophy 22084234 Cardiac hypertrophy is positively regulated by miR-23a. -other hsa-let-7a-1 Pancreatic Neoplasms 22086681 "We found that metformin significantly decreased cell survival, clonogenicity, wound healing capacity, sphere-forming capacity (pancreatospheres), and increased disintegration of pancreatospheres in both gemcitabine-sensitive and gemcitabine-resistant PC cells. Metformin also decreased the expression of CSC markers, CD44, EpCAM, EZH2, Notch-1, Nanog and Oct4, and caused re-expression of miRNAs (let-7a, b, miR-26a, miR-101, and miR-200b, c) that are typically lost in PC and especially in pancreatospheres. We also found that re-expression of miR-26a by transfection led to decreased expression of EZH2 and EpCAM in PC cells." -other hsa-let-7a-2 Pancreatic Neoplasms 22086681 "We found that metformin significantly decreased cell survival, clonogenicity, wound healing capacity, sphere-forming capacity (pancreatospheres), and increased disintegration of pancreatospheres in both gemcitabine-sensitive and gemcitabine-resistant PC cells. Metformin also decreased the expression of CSC markers, CD44, EpCAM, EZH2, Notch-1, Nanog and Oct4, and caused re-expression of miRNAs (let-7a, b, miR-26a, miR-101, and miR-200b, c) that are typically lost in PC and especially in pancreatospheres. We also found that re-expression of miR-26a by transfection led to decreased expression of EZH2 and EpCAM in PC cells." -other hsa-let-7a-3 Pancreatic Neoplasms 22086681 "We found that metformin significantly decreased cell survival, clonogenicity, wound healing capacity, sphere-forming capacity (pancreatospheres), and increased disintegration of pancreatospheres in both gemcitabine-sensitive and gemcitabine-resistant PC cells. Metformin also decreased the expression of CSC markers, CD44, EpCAM, EZH2, Notch-1, Nanog and Oct4, and caused re-expression of miRNAs (let-7a, b, miR-26a, miR-101, and miR-200b, c) that are typically lost in PC and especially in pancreatospheres. We also found that re-expression of miR-26a by transfection led to decreased expression of EZH2 and EpCAM in PC cells." -other hsa-let-7b Pancreatic Neoplasms 22086681 "We found that metformin significantly decreased cell survival, clonogenicity, wound healing capacity, sphere-forming capacity (pancreatospheres), and increased disintegration of pancreatospheres in both gemcitabine-sensitive and gemcitabine-resistant PC cells. Metformin also decreased the expression of CSC markers, CD44, EpCAM, EZH2, Notch-1, Nanog and Oct4, and caused re-expression of miRNAs (let-7a, b, miR-26a, miR-101, and miR-200b, c) that are typically lost in PC and especially in pancreatospheres. We also found that re-expression of miR-26a by transfection led to decreased expression of EZH2 and EpCAM in PC cells." -other hsa-mir-101-1 Pancreatic Neoplasms 22086681 "We found that metformin significantly decreased cell survival, clonogenicity, wound healing capacity, sphere-forming capacity (pancreatospheres), and increased disintegration of pancreatospheres in both gemcitabine-sensitive and gemcitabine-resistant PC cells. Metformin also decreased the expression of CSC markers, CD44, EpCAM, EZH2, Notch-1, Nanog and Oct4, and caused re-expression of miRNAs (let-7a, b, miR-26a, miR-101, and miR-200b, c) that are typically lost in PC and especially in pancreatospheres. We also found that re-expression of miR-26a by transfection led to decreased expression of EZH2 and EpCAM in PC cells." -other hsa-mir-101-2 Pancreatic Neoplasms 22086681 "We found that metformin significantly decreased cell survival, clonogenicity, wound healing capacity, sphere-forming capacity (pancreatospheres), and increased disintegration of pancreatospheres in both gemcitabine-sensitive and gemcitabine-resistant PC cells. Metformin also decreased the expression of CSC markers, CD44, EpCAM, EZH2, Notch-1, Nanog and Oct4, and caused re-expression of miRNAs (let-7a, b, miR-26a, miR-101, and miR-200b, c) that are typically lost in PC and especially in pancreatospheres. We also found that re-expression of miR-26a by transfection led to decreased expression of EZH2 and EpCAM in PC cells." -other hsa-mir-200b Pancreatic Neoplasms 22086681 "We found that metformin significantly decreased cell survival, clonogenicity, wound healing capacity, sphere-forming capacity (pancreatospheres), and increased disintegration of pancreatospheres in both gemcitabine-sensitive and gemcitabine-resistant PC cells. Metformin also decreased the expression of CSC markers, CD44, EpCAM, EZH2, Notch-1, Nanog and Oct4, and caused re-expression of miRNAs (let-7a, b, miR-26a, miR-101, and miR-200b, c) that are typically lost in PC and especially in pancreatospheres. We also found that re-expression of miR-26a by transfection led to decreased expression of EZH2 and EpCAM in PC cells." -other hsa-mir-200c Pancreatic Neoplasms 22086681 "We found that metformin significantly decreased cell survival, clonogenicity, wound healing capacity, sphere-forming capacity (pancreatospheres), and increased disintegration of pancreatospheres in both gemcitabine-sensitive and gemcitabine-resistant PC cells. Metformin also decreased the expression of CSC markers, CD44, EpCAM, EZH2, Notch-1, Nanog and Oct4, and caused re-expression of miRNAs (let-7a, b, miR-26a, miR-101, and miR-200b, c) that are typically lost in PC and especially in pancreatospheres. We also found that re-expression of miR-26a by transfection led to decreased expression of EZH2 and EpCAM in PC cells." -other hsa-mir-26a-1 Pancreatic Neoplasms 22086681 "We found that metformin significantly decreased cell survival, clonogenicity, wound healing capacity, sphere-forming capacity (pancreatospheres), and increased disintegration of pancreatospheres in both gemcitabine-sensitive and gemcitabine-resistant PC cells. Metformin also decreased the expression of CSC markers, CD44, EpCAM, EZH2, Notch-1, Nanog and Oct4, and caused re-expression of miRNAs (let-7a, b, miR-26a, miR-101, and miR-200b, c) that are typically lost in PC and especially in pancreatospheres. We also found that re-expression of miR-26a by transfection led to decreased expression of EZH2 and EpCAM in PC cells." -other hsa-mir-26a-2 Pancreatic Neoplasms 22086681 "We found that metformin significantly decreased cell survival, clonogenicity, wound healing capacity, sphere-forming capacity (pancreatospheres), and increased disintegration of pancreatospheres in both gemcitabine-sensitive and gemcitabine-resistant PC cells. Metformin also decreased the expression of CSC markers, CD44, EpCAM, EZH2, Notch-1, Nanog and Oct4, and caused re-expression of miRNAs (let-7a, b, miR-26a, miR-101, and miR-200b, c) that are typically lost in PC and especially in pancreatospheres. We also found that re-expression of miR-26a by transfection led to decreased expression of EZH2 and EpCAM in PC cells." -other hsa-mir-140 "Hand, Foot And Mouth Disease" 22087245 "A receiver operating characteristic (ROC) curve analysis revealed that six serum miRNAs (miR-148a, miR-143, miR-324-3p, miR-628-3p, miR-140-5p, and miR-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (AUC) values ranged from 0.828 to 0.934. The combined six miRNA using multiple logistic regression analysis provided not only a sensitivity of 97.1% and a specificity of 92.7% but also a unique profile that differentiated enterovirial infections from other microbial infections. Expression levels of five miRNAs (miR-148a, miR-143, miR-324-3p, miR-545, and miR-140-5p) were significantly increased in patients with CVA16 versus those with EV71 (p<0.05). Combination of miR-545, miR-324-3p, and miR-143 possessed a moderate ability to discrimination between CVA16 and EV71 with an AUC value of 0.761." -other hsa-mir-143 "Hand, Foot And Mouth Disease" 22087245 "A receiver operating characteristic (ROC) curve analysis revealed that six serum miRNAs (miR-148a, miR-143, miR-324-3p, miR-628-3p, miR-140-5p, and miR-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (AUC) values ranged from 0.828 to 0.934. The combined six miRNA using multiple logistic regression analysis provided not only a sensitivity of 97.1% and a specificity of 92.7% but also a unique profile that differentiated enterovirial infections from other microbial infections. Expression levels of five miRNAs (miR-148a, miR-143, miR-324-3p, miR-545, and miR-140-5p) were significantly increased in patients with CVA16 versus those with EV71 (p<0.05). Combination of miR-545, miR-324-3p, and miR-143 possessed a moderate ability to discrimination between CVA16 and EV71 with an AUC value of 0.761." -other hsa-mir-148a "Hand, Foot And Mouth Disease" 22087245 "A receiver operating characteristic (ROC) curve analysis revealed that six serum miRNAs (miR-148a, miR-143, miR-324-3p, miR-628-3p, miR-140-5p, and miR-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (AUC) values ranged from 0.828 to 0.934. The combined six miRNA using multiple logistic regression analysis provided not only a sensitivity of 97.1% and a specificity of 92.7% but also a unique profile that differentiated enterovirial infections from other microbial infections. Expression levels of five miRNAs (miR-148a, miR-143, miR-324-3p, miR-545, and miR-140-5p) were significantly increased in patients with CVA16 versus those with EV71 (p<0.05). Combination of miR-545, miR-324-3p, and miR-143 possessed a moderate ability to discrimination between CVA16 and EV71 with an AUC value of 0.761." -other hsa-mir-324 "Hand, Foot And Mouth Disease" 22087245 "A receiver operating characteristic (ROC) curve analysis revealed that six serum miRNAs (miR-148a, miR-143, miR-324-3p, miR-628-3p, miR-140-5p, and miR-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (AUC) values ranged from 0.828 to 0.934. The combined six miRNA using multiple logistic regression analysis provided not only a sensitivity of 97.1% and a specificity of 92.7% but also a unique profile that differentiated enterovirial infections from other microbial infections. Expression levels of five miRNAs (miR-148a, miR-143, miR-324-3p, miR-545, and miR-140-5p) were significantly increased in patients with CVA16 versus those with EV71 (p<0.05). Combination of miR-545, miR-324-3p, and miR-143 possessed a moderate ability to discrimination between CVA16 and EV71 with an AUC value of 0.761." -other hsa-mir-362 "Hand, Foot And Mouth Disease" 22087245 "A receiver operating characteristic (ROC) curve analysis revealed that six serum miRNAs (miR-148a, miR-143, miR-324-3p, miR-628-3p, miR-140-5p, and miR-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (AUC) values ranged from 0.828 to 0.934. The combined six miRNA using multiple logistic regression analysis provided not only a sensitivity of 97.1% and a specificity of 92.7% but also a unique profile that differentiated enterovirial infections from other microbial infections. Expression levels of five miRNAs (miR-148a, miR-143, miR-324-3p, miR-545, and miR-140-5p) were significantly increased in patients with CVA16 versus those with EV71 (p<0.05). Combination of miR-545, miR-324-3p, and miR-143 possessed a moderate ability to discrimination between CVA16 and EV71 with an AUC value of 0.761." -other hsa-mir-545 "Hand, Foot And Mouth Disease" 22087245 "A receiver operating characteristic (ROC) curve analysis revealed that six serum miRNAs (miR-148a, miR-143, miR-324-3p, miR-628-3p, miR-140-5p, and miR-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (AUC) values ranged from 0.828 to 0.934. The combined six miRNA using multiple logistic regression analysis provided not only a sensitivity of 97.1% and a specificity of 92.7% but also a unique profile that differentiated enterovirial infections from other microbial infections. Expression levels of five miRNAs (miR-148a, miR-143, miR-324-3p, miR-545, and miR-140-5p) were significantly increased in patients with CVA16 versus those with EV71 (p<0.05). Combination of miR-545, miR-324-3p, and miR-143 possessed a moderate ability to discrimination between CVA16 and EV71 with an AUC value of 0.761." -other hsa-mir-628 "Hand, Foot And Mouth Disease" 22087245 "A receiver operating characteristic (ROC) curve analysis revealed that six serum miRNAs (miR-148a, miR-143, miR-324-3p, miR-628-3p, miR-140-5p, and miR-362-3p) were able to discriminate patients with enterovirus infections from healthy controls with area under curve (AUC) values ranged from 0.828 to 0.934. The combined six miRNA using multiple logistic regression analysis provided not only a sensitivity of 97.1% and a specificity of 92.7% but also a unique profile that differentiated enterovirial infections from other microbial infections. Expression levels of five miRNAs (miR-148a, miR-143, miR-324-3p, miR-545, and miR-140-5p) were significantly increased in patients with CVA16 versus those with EV71 (p<0.05). Combination of miR-545, miR-324-3p, and miR-143 possessed a moderate ability to discrimination between CVA16 and EV71 with an AUC value of 0.761." -other hsa-mir-133a-1 Lung Neoplasms 22089643 Tumor suppressive microRNA-133a regulates novel molecular networks in lung squamous cell carcinoma. -other hsa-mir-15b Heart Failure 22093502 "The real-time PCR confirmed lower expression in LV recovery patients for 4 miRs (15b, -1.5-fold; 23a, -2.2-fold; 26a, -1.4-fold; and 195, -1.8-fold; all p < 0.04 vs. VAD dependent). The validation cohort similarly showed lower miRs expression in LV recovery patients (23a, -1.8-fold; and 195, -1.5-fold; both p < 0.03). Furthermore, miR 23a and 195 expression in nonfailing hearts was similar to LV recovery patients (both p < 0.04 vs. VAD dependent)." -other hsa-mir-195 Heart Failure 22093502 "The real-time PCR confirmed lower expression in LV recovery patients for 4 miRs (15b, -1.5-fold; 23a, -2.2-fold; 26a, -1.4-fold; and 195, -1.8-fold; all p < 0.04 vs. VAD dependent). The validation cohort similarly showed lower miRs expression in LV recovery patients (23a, -1.8-fold; and 195, -1.5-fold; both p < 0.03). Furthermore, miR 23a and 195 expression in nonfailing hearts was similar to LV recovery patients (both p < 0.04 vs. VAD dependent)." -other hsa-mir-23a Heart Failure 22093502 "The real-time PCR confirmed lower expression in LV recovery patients for 4 miRs (15b, -1.5-fold; 23a, -2.2-fold; 26a, -1.4-fold; and 195, -1.8-fold; all p < 0.04 vs. VAD dependent). The validation cohort similarly showed lower miRs expression in LV recovery patients (23a, -1.8-fold; and 195, -1.5-fold; both p < 0.03). Furthermore, miR 23a and 195 expression in nonfailing hearts was similar to LV recovery patients (both p < 0.04 vs. VAD dependent)." -other hsa-mir-26a-1 Heart Failure 22093502 "The real-time PCR confirmed lower expression in LV recovery patients for 4 miRs (15b, -1.5-fold; 23a, -2.2-fold; 26a, -1.4-fold; and 195, -1.8-fold; all p < 0.04 vs. VAD dependent). The validation cohort similarly showed lower miRs expression in LV recovery patients (23a, -1.8-fold; and 195, -1.5-fold; both p < 0.03). Furthermore, miR 23a and 195 expression in nonfailing hearts was similar to LV recovery patients (both p < 0.04 vs. VAD dependent)." -other hsa-mir-26a-2 Heart Failure 22093502 "The real-time PCR confirmed lower expression in LV recovery patients for 4 miRs (15b, -1.5-fold; 23a, -2.2-fold; 26a, -1.4-fold; and 195, -1.8-fold; all p < 0.04 vs. VAD dependent). The validation cohort similarly showed lower miRs expression in LV recovery patients (23a, -1.8-fold; and 195, -1.5-fold; both p < 0.03). Furthermore, miR 23a and 195 expression in nonfailing hearts was similar to LV recovery patients (both p < 0.04 vs. VAD dependent)." -other hsa-mir-26a-1 Breast Neoplasms 22094936 High miR-26a and low CDC2 levels associate with decreased EZH2 expression and with favorable outcome on tamoxifen in metastatic breast cancer. -other hsa-mir-26a-2 Breast Neoplasms 22094936 High miR-26a and low CDC2 levels associate with decreased EZH2 expression and with favorable outcome on tamoxifen in metastatic breast cancer. -other hsa-mir-155 Lymphoma 22096245 miR-155 regulates HGAL expression and increases lymphoma cell motility. -other hsa-mir-141 Ovarian Neoplasms 22101765 miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response. -other hsa-mir-200a Ovarian Neoplasms 22101765 miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response. -other hsa-mir-34a Melanoma 22102694 "Tumor suppressive microRNAs miR-34a/c control cancer cell expression of ULBP2, a stress induced ligand of the natural killer cell receptor NKG2D." -other hsa-mir-34c Melanoma 22102694 "Tumor suppressive microRNAs miR-34a/c control cancer cell expression of ULBP2, a stress induced ligand of the natural killer cell receptor NKG2D." -other hsa-mir-34a Breast Neoplasms 22102859 MiR-34a Expression Has an Effect for Lower Risk of Metastasis and Associates with Expression Patterns Predicting Clinical Outcome in Breast Cancer. -other hsa-mir-23b Colon Neoplasms 22109528 Genome-wide functional screening of miR-23b as a pleiotropic modulator suppressing cancer metastasis. -other hsa-mir-1 Heart Failure 22110643 "We conclude that miR-1 and -499 play differential roles in cardiac differentiation of hESCs in a context-dependent fashion. While miR-499 promotes ventricular specification of hESCs, miR-1 serves to facilitate electrophysiological maturation." -other hsa-mir-499 Heart Failure 22110643 "We conclude that miR-1 and -499 play differential roles in cardiac differentiation of hESCs in a context-dependent fashion. While miR-499 promotes ventricular specification of hESCs, miR-1 serves to facilitate electrophysiological maturation." -other hsa-mir-126 Myocardial Infarction 22113756 "Transplantation of MSCs transfected with miR-126 can improve angiogenesis and cardiac function in the infarcted area of the hearts of mice, which may be due to stimulation of the AKT/ERK-related pathway." -other hsa-mir-155 Waldenstrom Macroglobulinemia 22122052 "Among deregulated miRNAs, miR-155 and miR-9* play a pivotal role in the pathogenesis of this disease." -other hsa-mir-9 Waldenstrom Macroglobulinemia 22122052 "Among deregulated miRNAs, miR-155 and miR-9* play a pivotal role in the pathogenesis of this disease." -other hsa-mir-210 Ischemic Diseases [unspecific] 22123256 Upregulation of microRNA-210 regulates renal angiogenesis mediated by activation of VEGF signaling pathway under ischemia/perfusion injury in vivo and in vitro. -other hsa-let-7a Neoplasms [unspecific] 22129484 "The let-7 family of microRNAs has cancer suppressor activity, and recent evidence suggests that markedly reduced levels of let-7 are not only a typical feature of cancer stem cells, but may be largely responsible for cancer stemness." -other hsa-let-7b Neoplasms [unspecific] 22129484 "The let-7 family of microRNAs has cancer suppressor activity, and recent evidence suggests that markedly reduced levels of let-7 are not only a typical feature of cancer stem cells, but may be largely responsible for cancer stemness." -other hsa-let-7c Neoplasms [unspecific] 22129484 "The let-7 family of microRNAs has cancer suppressor activity, and recent evidence suggests that markedly reduced levels of let-7 are not only a typical feature of cancer stem cells, but may be largely responsible for cancer stemness." -other hsa-let-7d Neoplasms [unspecific] 22129484 "The let-7 family of microRNAs has cancer suppressor activity, and recent evidence suggests that markedly reduced levels of let-7 are not only a typical feature of cancer stem cells, but may be largely responsible for cancer stemness." -other hsa-let-7e Neoplasms [unspecific] 22129484 "The let-7 family of microRNAs has cancer suppressor activity, and recent evidence suggests that markedly reduced levels of let-7 are not only a typical feature of cancer stem cells, but may be largely responsible for cancer stemness." -other hsa-let-7f Neoplasms [unspecific] 22129484 "The let-7 family of microRNAs has cancer suppressor activity, and recent evidence suggests that markedly reduced levels of let-7 are not only a typical feature of cancer stem cells, but may be largely responsible for cancer stemness." -other hsa-let-7g Neoplasms [unspecific] 22129484 "The let-7 family of microRNAs has cancer suppressor activity, and recent evidence suggests that markedly reduced levels of let-7 are not only a typical feature of cancer stem cells, but may be largely responsible for cancer stemness." -other hsa-let-7i Neoplasms [unspecific] 22129484 "The let-7 family of microRNAs has cancer suppressor activity, and recent evidence suggests that markedly reduced levels of let-7 are not only a typical feature of cancer stem cells, but may be largely responsible for cancer stemness." -other hsa-mir-202 Neoplasms [unspecific] 22129484 "The let-7 family of microRNAs has cancer suppressor activity, and recent evidence suggests that markedly reduced levels of let-7 are not only a typical feature of cancer stem cells, but may be largely responsible for cancer stemness." -other hsa-mir-98 Neoplasms [unspecific] 22129484 "The let-7 family of microRNAs has cancer suppressor activity, and recent evidence suggests that markedly reduced levels of let-7 are not only a typical feature of cancer stem cells, but may be largely responsible for cancer stemness." -other hsa-mir-182 Medulloblastoma 22134538 MicroRNA-182 promotes leptomeningeal spread of non-sonic hedgehog-medulloblastoma. -other hsa-mir-143 Cardiovascular Diseases [unspecific] 22135162 "MicroRNAs are critical for vascular smooth muscle cell differentiation and phenotype regulation, and miR-143 and miR-145 play a particularly important role in this respect." -other hsa-mir-145 Cardiovascular Diseases [unspecific] 22135162 "MicroRNAs are critical for vascular smooth muscle cell differentiation and phenotype regulation, and miR-143 and miR-145 play a particularly important role in this respect." -other hsa-mir-135a-1 Glioma 22139076 MiR-135a functions as a selective killer of malignant glioma. -other hsa-mir-135a-2 Glioma 22139076 MiR-135a functions as a selective killer of malignant glioma. -other hsa-mir-7-1 Gastric Neoplasms 22139078 Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells. -other hsa-mir-7-2 Gastric Neoplasms 22139078 Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells. -other hsa-mir-7-3 Gastric Neoplasms 22139078 Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells. -other hsa-mir-30c-1 Endometrial Neoplasms 22139444 Endometrial Neoplasms -other hsa-mir-30c-2 Endometrial Neoplasms 22139444 Endometrial Neoplasms -other hsa-mir-494 Lung Neoplasms 22151897 MicroRNA-494 suppresses cell proliferation and induces senescence in A549 lung cancer cells. -other hsa-mir-30e Glioma 22156201 MicroRNA-30e* promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-§Ø¨mB/I§Ø¨mB§Ø©ãnegative feedback loop. -other hsa-mir-1301 "Carcinoma, Hepatocellular" 22159405 microRNA-1301-mediated inhibition of tumorigenesis. -other hsa-mir-96 "Carcinoma, Hepatocellular" 22160187 Suppression of microRNA-96 expression inhibits the invasion of hepatocellular carcinoma cells. -other hsa-mir-17 Hypertension 22161164 Inhibition of microRNA-17 Improves Lung and Heart Function in Experimental Pulmonary Hypertension. -other hsa-mir-1-1 Heart Failure 22163007 MicroRNA-1 and -133 Increase Arrhythmogenesis in Heart Failure by Dissociating Phosphatase Activity from RyR2 Complex. -other hsa-mir-1-2 Heart Failure 22163007 MicroRNA-1 and -133 Increase Arrhythmogenesis in Heart Failure by Dissociating Phosphatase Activity from RyR2 Complex. -other hsa-mir-133a-1 Heart Failure 22163007 MicroRNA-1 and -133 Increase Arrhythmogenesis in Heart Failure by Dissociating Phosphatase Activity from RyR2 Complex. -other hsa-mir-133a-2 Heart Failure 22163007 MicroRNA-1 and -133 Increase Arrhythmogenesis in Heart Failure by Dissociating Phosphatase Activity from RyR2 Complex. -other hsa-mir-133b Heart Failure 22163007 MicroRNA-1 and -133 Increase Arrhythmogenesis in Heart Failure by Dissociating Phosphatase Activity from RyR2 Complex. -other hsa-mir-29a Biliary Atresia 22167021 MicroRNA Profiling Identifies miR-29 as a Regulator of Disease-Associated Pathways in Experimental Biliary Atresia. -other hsa-mir-29b-1 Biliary Atresia 22167021 MicroRNA Profiling Identifies miR-29 as a Regulator of Disease-Associated Pathways in Experimental Biliary Atresia. -other hsa-let-7a Gastrointestinal Neoplasms 22168593 "The aim of the present review was to describe the mechanisms of several known miR, summarize recent studies on oncogenic miR (e.g. miR-21, miR-106a and miR-17), tumor suppressor miR (e.g. miR-101, miR-181, miR-449, miR-486, let-7a) and controversial roles of miR (e.g. miR-107, miR-126) for gastric cancer." -other hsa-mir-101 Gastrointestinal Neoplasms 22168593 "The aim of the present review was to describe the mechanisms of several known miR, summarize recent studies on oncogenic miR (e.g. miR-21, miR-106a and miR-17), tumor suppressor miR (e.g. miR-101, miR-181, miR-449, miR-486, let-7a) and controversial roles of miR (e.g. miR-107, miR-126) for gastric cancer." -other hsa-mir-106a Gastrointestinal Neoplasms 22168593 "The aim of the present review was to describe the mechanisms of several known miR, summarize recent studies on oncogenic miR (e.g. miR-21, miR-106a and miR-17), tumor suppressor miR (e.g. miR-101, miR-181, miR-449, miR-486, let-7a) and controversial roles of miR (e.g. miR-107, miR-126) for gastric cancer." -other hsa-mir-107 Gastrointestinal Neoplasms 22168593 "The aim of the present review was to describe the mechanisms of several known miR, summarize recent studies on oncogenic miR (e.g. miR-21, miR-106a and miR-17), tumor suppressor miR (e.g. miR-101, miR-181, miR-449, miR-486, let-7a) and controversial roles of miR (e.g. miR-107, miR-126) for gastric cancer." -other hsa-mir-126 Gastrointestinal Neoplasms 22168593 "The aim of the present review was to describe the mechanisms of several known miR, summarize recent studies on oncogenic miR (e.g. miR-21, miR-106a and miR-17), tumor suppressor miR (e.g. miR-101, miR-181, miR-449, miR-486, let-7a) and controversial roles of miR (e.g. miR-107, miR-126) for gastric cancer." -other hsa-mir-17 Gastrointestinal Neoplasms 22168593 "The aim of the present review was to describe the mechanisms of several known miR, summarize recent studies on oncogenic miR (e.g. miR-21, miR-106a and miR-17), tumor suppressor miR (e.g. miR-101, miR-181, miR-449, miR-486, let-7a) and controversial roles of miR (e.g. miR-107, miR-126) for gastric cancer." -other hsa-mir-181 Gastrointestinal Neoplasms 22168593 "The aim of the present review was to describe the mechanisms of several known miR, summarize recent studies on oncogenic miR (e.g. miR-21, miR-106a and miR-17), tumor suppressor miR (e.g. miR-101, miR-181, miR-449, miR-486, let-7a) and controversial roles of miR (e.g. miR-107, miR-126) for gastric cancer." -other hsa-mir-21 Gastrointestinal Neoplasms 22168593 "The aim of the present review was to describe the mechanisms of several known miR, summarize recent studies on oncogenic miR (e.g. miR-21, miR-106a and miR-17), tumor suppressor miR (e.g. miR-101, miR-181, miR-449, miR-486, let-7a) and controversial roles of miR (e.g. miR-107, miR-126) for gastric cancer." -other hsa-mir-449 Gastrointestinal Neoplasms 22168593 "The aim of the present review was to describe the mechanisms of several known miR, summarize recent studies on oncogenic miR (e.g. miR-21, miR-106a and miR-17), tumor suppressor miR (e.g. miR-101, miR-181, miR-449, miR-486, let-7a) and controversial roles of miR (e.g. miR-107, miR-126) for gastric cancer." -other hsa-mir-486 Gastrointestinal Neoplasms 22168593 "The aim of the present review was to describe the mechanisms of several known miR, summarize recent studies on oncogenic miR (e.g. miR-21, miR-106a and miR-17), tumor suppressor miR (e.g. miR-101, miR-181, miR-449, miR-486, let-7a) and controversial roles of miR (e.g. miR-107, miR-126) for gastric cancer." -other hsa-mir-335 Glioma 22172575 MiR-335 is Required for Differentiation of Malignant Glioma Cells Induced by Activation of cAMP/PKA Pathway. -other hsa-mir-574 Urinary Bladder Cancer 22179486 Novel oncogenic function of mesoderm development candidate 1 and its regulation by MiR-574-3p in bladder cancer cell lines. -other hsa-mir-1-1 Colon Neoplasms 22179665 MIR-1 DOWNREGULATION COOPERATES WITH MACC1 IN PROMOTING MET OVEREXPRESSION IN HUMAN COLON CANCER. -other hsa-mir-133b Urinary Bladder Cancer 22179829 MicroRNA-133b is a key promoter of cervical carcinoma development through the activation of the ERK and AKT1 pathways. -other hsa-mir-21 Breast Neoplasms 22187223 Re-expression of miR-21 contributes to migration and invasion by inducing epithelial-mesenchymal transition consistent with cancer stem cell characteristics in MCF-7 cells. -other hsa-mir-610 Gastric Neoplasms 22189055 MicroRNA-610 inhibits the migration and invasion of gastric cancer cells by suppressing the expression of vasodilator-stimulated phosphoprotein. -other hsa-mir-122 Hepatitis C Virus Infection 22189820 "Here we show that HCV IRES-dependent translation efficiency in the hepatoma cell line Huh7 is highest during the G 0 and G 1 phases of the cell cycle but significantly drops during the S phase and even more in the G 2/M phase. The superimposed stimulation of HCV translation by ectopic miR-122 works best during the G 0, G 1 and G 2/M phases but is lower during the S phase. However, the levels of Ago2 protein do not substantially change during cell cycle phases, indicating that other cellular factors involved in HCV translation stimulation by miR-122 may be differentially expressed in different cell cycle phases. Moreover, the levels of endogenously expressed miR-122 in Huh7 cells are lowest in the S phase, indicating that the predominant G 0/G 1 state of non-dividing hepatocytes in the liver facilitates high expression of the HCV genome and stimulation by miR-122, with yet unknown factors involved in the differential extent of stimulation by miR-122." -other hsa-mir-195 Heart Failure 22190509 "microRNA-195(miR-195) is an important member of the micro-15/16/195/424/497 family, and which is activated in multiple diseases, such as cancers, heart failure, and schizophrenia." -other hsa-mir-195 Schizophrenia 22190509 "microRNA-195(miR-195) is an important member of the micro-15/16/195/424/497 family, and which is activated in multiple diseases, such as cancers, heart failure, and schizophrenia." -other hsa-mir-34a Melanoma 22198089 "Our preliminary study suggests that miR-34a, although having a role in late tumorigenesis, does not contribute to the inherited susceptibility to cutaneous melanoma. " -other hsa-mir-106a Colorectal Carcinoma 22202009 "miR-20a, miR-21, miR-106a, miR-181b, miR-203, and miR-324-5p were stable in colorectal cancer archival tissue blocks." -other hsa-mir-181b-1 Colorectal Carcinoma 22202009 "miR-20a, miR-21, miR-106a, miR-181b, miR-203, and miR-324-5p were stable in colorectal cancer archival tissue blocks." -other hsa-mir-181b-2 Colorectal Carcinoma 22202009 "miR-20a, miR-21, miR-106a, miR-181b, miR-203, and miR-324-5p were stable in colorectal cancer archival tissue blocks." -other hsa-mir-203 Colorectal Carcinoma 22202009 "miR-20a, miR-21, miR-106a, miR-181b, miR-203, and miR-324-5p were stable in colorectal cancer archival tissue blocks." -other hsa-mir-20a Colorectal Carcinoma 22202009 "miR-20a, miR-21, miR-106a, miR-181b, miR-203, and miR-324-5p were stable in colorectal cancer archival tissue blocks." -other hsa-mir-21 Colorectal Carcinoma 22202009 "miR-20a, miR-21, miR-106a, miR-181b, miR-203, and miR-324-5p were stable in colorectal cancer archival tissue blocks." -other hsa-mir-324 Colorectal Carcinoma 22202009 "miR-20a, miR-21, miR-106a, miR-181b, miR-203, and miR-324-5p were stable in colorectal cancer archival tissue blocks." -other hsa-mir-451 Glioblastoma 22205943 "The model provides an explanation for the growth-invasion cycling patterns of glioma cells in response to high/low glucose uptake in microenvironment in vitro, and suggests new targets for drugs,associated with miR-451 upregulation." -other hsa-mir-31 Gastric Neoplasms 22212233 PDCD4 expression inversely correlated with miR-21 levels in gastric cancers. -other hsa-mir-520e "Carcinoma, Hepatocellular" 22212428 A novel tumor suppressor miRNA miR-520e contributes to suppression of hepatoma. -other hsa-mir-21 Cholangiocarcinoma 22213145 "Based on our data, we conclude that Ars2 is overexpressed in human CCA and may be a diagnostic marker. Ars2 depletion increases PTEN and PDCD4 protein levels via the reduction of miR-21." -other hsa-mir-125b-1 Melanoma 22213330 "Treatment with 5-Aza, but not with TSA, reduced the expression of miR-125b in the 1,25(OH)(2)D(3)-responsive and -resistant melanoma cell lines and in the NHM." -other hsa-mir-125b-2 Melanoma 22213330 "Treatment with 5-Aza, but not with TSA, reduced the expression of miR-125b in the 1,25(OH)(2)D(3)-responsive and -resistant melanoma cell lines and in the NHM." -other hsa-mir-27b Melanoma 22213330 "Treatment with 1,25(OH)(2)D(3) and/or epigenetic drugs (5-Aza, TSA) reduced the miR-27b expression in three out of four melanoma cell lines." -other hsa-mir-21 "Muscular Dystrophy, Duchenne" 22213800 PAI-1-regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophy. -other hsa-mir-126 Cardiovascular Diseases [unspecific] 22215713 miRNA-126 levels were reduced in SHRs with an increase of 51% in phosphoinositol-3 kinase regulatory subunit 2 expression but normalized in SHR-Ts. -other hsa-mir-26b Hypertrophy 22219180 GATA4 expression is primarily regulated via a miR-26b-dependent post-transcriptional mechanism during cardiac hypertrophy. -other hsa-mir-21 Pituitary Adenoma 22222153 "We speculated the mechanism of miR-21 is involved in tumorigenesis, leading to improvements in therapies and prevention of metastasis." -other hsa-mir-192 Diabetic Nephropathy 22223877 Inhibiting MicroRNA-192 Ameliorates Renal Fibrosis in Diabetic Nephropathy -other hsa-mir-650 "Leukemia, Lymphocytic, Chronic, B-Cell" 22234685 MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia. -other hsa-mir-34a Prostate Neoplasms 22235332 MicroRNA-34a modulates c-Myc transcriptional complexes to suppress malignancy in human prostate cancer cells. -other hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 22237007 "Increased miR-21 expression significantly increased the resistance of A549 cell to platinum, whereas reduced miR-21 decreased the resistance of A549/CDDP cell." -other hsa-mir-133b Parkinson Disease 22245218 "miR-133b is deficient in the PD midbrain as well as in mouse models, and miR-34b/34c are decreased in several affected brain regions in PD and incidental Lewy body disease." -other hsa-let-7c Pancreatic Neoplasms 22245693 "Metformin up-regulated the expression of miR-26a, miR-192 and let-7c in a dose-dependent manner." -other hsa-mir-192 Pancreatic Neoplasms 22245693 "Metformin up-regulated the expression of miR-26a, miR-192 and let-7c in a dose-dependent manner." -other hsa-mir-26a-1 Pancreatic Neoplasms 22245693 "Metformin up-regulated the expression of miR-26a, miR-192 and let-7c in a dose-dependent manner. Forced expression of miR-26a significantly inhibited cell proliferation, invasion, migration and increased cell apoptosis, whereas knockdown of miR-26a obtained the opposite effect." -other hsa-mir-26a-2 Pancreatic Neoplasms 22245693 "Metformin up-regulated the expression of miR-26a, miR-192 and let-7c in a dose-dependent manner. Forced expression of miR-26a significantly inhibited cell proliferation, invasion, migration and increased cell apoptosis, whereas knockdown of miR-26a obtained the opposite effect." -other hsa-mir-155 Breast Neoplasms 22245916 "Up-regulated miR-155 expression was associated with lymph node positivity (P=0.034), higher proliferation index (Ki-67 >10%) (P=0.019) and advanced breast cancer TNM clinical stage (P=0.002)." -other hsa-mir-100 "Carcinoma, Hepatocellular" 22249248 Sequential analysis of multistage hepatocarcinogenesis reveals that miR-100 and PLK1 dysregulation is an early event maintained along tumor progression. -other hsa-mir-155 Myelodysplastic Syndromes 22249254 Loss of SHIP-1 protein expression in high-risk myelodysplastic syndromes is associated with miR-210 and miR-155. -other hsa-mir-210 Myelodysplastic Syndromes 22249254 Loss of SHIP-1 protein expression in high-risk myelodysplastic syndromes is associated with miR-210 and miR-155. -other hsa-mir-21 "Carcinoma, Oral" 22249446 miR-21 inhibitor sensitizes human OSCC(oral squamous cell carcinoma) cells to cisplatin. -other hsa-mir-196a-1 Gastrointestinal Neoplasms 22258453 Upregulation of miR-196a and HOTAIR Drive Malignant Character in Gastrointestinal Stromal Tumors. -other hsa-mir-196a-2 Gastrointestinal Neoplasms 22258453 Upregulation of miR-196a and HOTAIR Drive Malignant Character in Gastrointestinal Stromal Tumors. -other hsa-mir-143 Breast Neoplasms 22260523 "E2 significantly induced bcl-2, cyclin D1 and survivin expression by suppressing the levels of a panel of miRNAs (miR-16, miR-143, miR-203) in MCF-7 cells." -other hsa-mir-16-1 Breast Neoplasms 22260523 "E2 significantly induced bcl-2, cyclin D1 and survivin expression by suppressing the levels of a panel of miRNAs (miR-16, miR-143, miR-203) in MCF-7 cells." -other hsa-mir-16-2 Breast Neoplasms 22260523 "E2 significantly induced bcl-2, cyclin D1 and survivin expression by suppressing the levels of a panel of miRNAs (miR-16, miR-143, miR-203) in MCF-7 cells." -other hsa-mir-203 Breast Neoplasms 22260523 "E2 significantly induced bcl-2, cyclin D1 and survivin expression by suppressing the levels of a panel of miRNAs (miR-16, miR-143, miR-203) in MCF-7 cells." -other hsa-mir-24-1 Myocardial Infarction 22260784 MicroRNA-24 Regulates Cardiac Fibrosis after Myocardial Infarction. -other hsa-mir-24-2 Myocardial Infarction 22260784 MicroRNA-24 Regulates Cardiac Fibrosis after Myocardial Infarction. -other hsa-mir-125b-1 Neoplasms [unspecific] 22268450 Camptothecin Induces Apoptosis in Cancer Cells via miR-125b Mediated Mitochondrial Pathways. -other hsa-mir-125b-2 Neoplasms [unspecific] 22268450 Camptothecin Induces Apoptosis in Cancer Cells via miR-125b Mediated Mitochondrial Pathways. -other hsa-mir-155 Lymphoma 22268450 Epstein-Barr virus latent membrane protein-1 protects B-cell lymphoma from rituximab-induced apoptosis through miR-155-mediated Akt activation and up-regulation of Mcl-1. -other hsa-mir-145 Glioma 22269208 Over-expression of miR-145 enhances the effectiveness of HSVtk gene therapy for malignant glioma. -other hsa-mir-140 Osteoarthritis 22273691 Expression of miRNA-140 and MMP-13 was elevated in IL-1¦Â-stimulated C28/I2 cells. -other hsa-mir-33a Atherosclerosis 22274626 microRNA-33a and b (miR-33a/b) were discovered as key regulators of metabolic programs including cholesterol and fatty acid homeostasis. -other hsa-mir-33b Atherosclerosis 22274626 microRNA-33a and b (miR-33a/b) were discovered as key regulators of metabolic programs including cholesterol and fatty acid homeostasis. -other hsa-mir-21 Colorectal Carcinoma 22281474 "Aging and DMH are associated with increases in CSLC biomarkers and miR21, each of which have been linked to colorectal cancer." -other hsa-mir-199a-1 Leukemia 22285730 Low microRNA-199a expression in human amniotic epithelial cell feeder layers maintains human-induced pluripotent stem cell pluripotency via increased leukemia inhibitory factor expression. -other hsa-mir-199a-2 Leukemia 22285730 Low microRNA-199a expression in human amniotic epithelial cell feeder layers maintains human-induced pluripotent stem cell pluripotency via increased leukemia inhibitory factor expression. -other hsa-mir-145 Urinary Bladder Cancer 22287315 Glucocorticoid regulation of a novel HPV E6-p53-miR-145 pathway modulates invasion and therapy resistance of cervical cancer cells. -other hsa-mir-200b Crohn Disease 22294131 miR-200b is involved in intestinal fibrosis of Crohn's disease. -other hsa-mir-106a "Carcinoma, Lung, Non-Small-Cell" 22295063 "The significantly altered angiogenesis-related miRs of high interest were miR-21, miR-106a, miR-126, miR-155, miR-182, miR-210 and miR-424. miR-155 correlated significantly with fibroblast growth factor 2 (FGF2) in the total cohort (r=0.17, P=0.002), though most prominent in the subgroup with nodal metastasis (r=0.34, P<0.001)." -other hsa-mir-126 "Carcinoma, Lung, Non-Small-Cell" 22295063 "The significantly altered angiogenesis-related miRs of high interest were miR-21, miR-106a, miR-126, miR-155, miR-182, miR-210 and miR-424. miR-155 correlated significantly with fibroblast growth factor 2 (FGF2) in the total cohort (r=0.17, P=0.002), though most prominent in the subgroup with nodal metastasis (r=0.34, P<0.001)." -other hsa-mir-155 "Carcinoma, Lung, Non-Small-Cell" 22295063 "The significantly altered angiogenesis-related miRs of high interest were miR-21, miR-106a, miR-126, miR-155, miR-182, miR-210 and miR-424. miR-155 correlated significantly with fibroblast growth factor 2 (FGF2) in the total cohort (r=0.17, P=0.002), though most prominent in the subgroup with nodal metastasis (r=0.34, P<0.001)." -other hsa-mir-182 "Carcinoma, Lung, Non-Small-Cell" 22295063 "The significantly altered angiogenesis-related miRs of high interest were miR-21, miR-106a, miR-126, miR-155, miR-182, miR-210 and miR-424. miR-155 correlated significantly with fibroblast growth factor 2 (FGF2) in the total cohort (r=0.17, P=0.002), though most prominent in the subgroup with nodal metastasis (r=0.34, P<0.001)." -other hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 22295063 "The significantly altered angiogenesis-related miRs of high interest were miR-21, miR-106a, miR-126, miR-155, miR-182, miR-210 and miR-424. miR-155 correlated significantly with fibroblast growth factor 2 (FGF2) in the total cohort (r=0.17, P=0.002), though most prominent in the subgroup with nodal metastasis (r=0.34, P<0.001)." -other hsa-mir-210 "Carcinoma, Lung, Non-Small-Cell" 22295063 "The significantly altered angiogenesis-related miRs of high interest were miR-21, miR-106a, miR-126, miR-155, miR-182, miR-210 and miR-424. miR-155 correlated significantly with fibroblast growth factor 2 (FGF2) in the total cohort (r=0.17, P=0.002), though most prominent in the subgroup with nodal metastasis (r=0.34, P<0.001)." -other hsa-mir-424 "Carcinoma, Lung, Non-Small-Cell" 22295063 "The significantly altered angiogenesis-related miRs of high interest were miR-21, miR-106a, miR-126, miR-155, miR-182, miR-210 and miR-424. miR-155 correlated significantly with fibroblast growth factor 2 (FGF2) in the total cohort (r=0.17, P=0.002), though most prominent in the subgroup with nodal metastasis (r=0.34, P<0.001)." -other hsa-let-7a-1 Lung Neoplasms 22301433 Reduced miR-31 and let-7 maintain the balance between differentiation and quiescence in lung cancer stem-like side population cells. -other hsa-let-7a-2 Lung Neoplasms 22301433 Reduced miR-31 and let-7 maintain the balance between differentiation and quiescence in lung cancer stem-like side population cells. -other hsa-let-7a-3 Lung Neoplasms 22301433 Reduced miR-31 and let-7 maintain the balance between differentiation and quiescence in lung cancer stem-like side population cells. -other hsa-let-7b Lung Neoplasms 22301433 Reduced miR-31 and let-7 maintain the balance between differentiation and quiescence in lung cancer stem-like side population cells. -other hsa-let-7c Lung Neoplasms 22301433 Reduced miR-31 and let-7 maintain the balance between differentiation and quiescence in lung cancer stem-like side population cells. -other hsa-let-7d Lung Neoplasms 22301433 Reduced miR-31 and let-7 maintain the balance between differentiation and quiescence in lung cancer stem-like side population cells. -other hsa-let-7e Lung Neoplasms 22301433 Reduced miR-31 and let-7 maintain the balance between differentiation and quiescence in lung cancer stem-like side population cells. -other hsa-let-7f-1 Lung Neoplasms 22301433 Reduced miR-31 and let-7 maintain the balance between differentiation and quiescence in lung cancer stem-like side population cells. -other hsa-let-7f-2 Lung Neoplasms 22301433 Reduced miR-31 and let-7 maintain the balance between differentiation and quiescence in lung cancer stem-like side population cells. -other hsa-let-7g Lung Neoplasms 22301433 Reduced miR-31 and let-7 maintain the balance between differentiation and quiescence in lung cancer stem-like side population cells. -other hsa-let-7i Lung Neoplasms 22301433 Reduced miR-31 and let-7 maintain the balance between differentiation and quiescence in lung cancer stem-like side population cells. -other hsa-mir-31 Lung Neoplasms 22301433 Reduced miR-31 and let-7 maintain the balance between differentiation and quiescence in lung cancer stem-like side population cells. -other hsa-mir-31 Barrett Esophagus 22302717 "The authors propose miR-31 and -375 as novel candidate microRNAs specifically associated with early- and late-stage malignant progression, respectively, in Barrett's esophagus." -other hsa-mir-375 Barrett Esophagus 22302717 "The authors propose miR-31 and -375 as novel candidate microRNAs specifically associated with early- and late-stage malignant progression, respectively, in Barrett's esophagus." -other hsa-mir-181c Fanconi Anemia 22310912 Downregulated expression of hsa-miR-181c in Fanconi anemia patients: implications in TNF§Ø©ãregulation and proliferation of hematopoietic progenitor cells. -other hsa-mir-146a Pancreatic Neoplasms 22311263 Aberrant elevated microRNA-146a in dendritic cells (DC) induced by human pancreatic cancer cell line BxPC-3-conditioned medium inhibits DC maturation and activation. -other hsa-mir-125a Gastric Neoplasms 22322911 "Low expression levels of miR-125a-3p were associated with indicators of enhanced malignant potential such as tumor size (p=0.0002), tumor invasion (p=0.0149), lymph node metastasis (p=0.018), liver metastasis (p=0.016), peritoneal dissemination (p=0.03), advanced clinical stage (p=0.0037) and poor prognosis (p=0.0083)." -other hsa-mir-10b Colorectal Carcinoma 22322955 MicroRNA-10b is a Prognostic Indicator in Colorectal Cancer and Confers Resistance to the Chemotherapeutic Agent 5-Fluorouracil in Colorectal Cancer Cells. -other hsa-mir-1 Heart Failure 22326846 These findings demonstrate the importance of miR-1 in cardiac function and in the pathogenesis of heart failure via Sorcin-dependent calcium homeostasis. -other hsa-mir-22 Colon Neoplasms 22328083 "MicroRNA-22 is induced by vitamin D and contributes to its antiproliferative, antimigratory and gene regulatory effects in colon cancer cells." -other hsa-mir-145 "Carcinoma, Lung, Non-Small-Cell" 22331473 "miR-145* inhibits cell invasion and metastasis, and is associated with brain metastasis." -other hsa-mir-15a Breast Neoplasms 22335947 "The expression level of miR-15a in MCF-7 cells was lower than that in the MCF-10A cells (0.253:1, P < 0.0001). The expression of MiR-15a was significantly inhibited by Bcl-2 (P < 0.05)." -other hsa-mir-199a-2 Sezary Disease 22336940 Deep-Sequencing Analysis Reveals that the miR-199a2/214 Cluster within DNM3os Represents the Vast Majority of Aberrantly Expressed MicroRNAs in S§Ú§Øzary Syndrome. -other hsa-mir-214 Sezary Disease 22336940 Deep-Sequencing Analysis Reveals that the miR-199a2/214 Cluster within DNM3os Represents the Vast Majority of Aberrantly Expressed MicroRNAs in S§Ú§Øzary Syndrome. -other hsa-mir-122 Hepatitis C Virus Infection 22342424 Suppression of hepatitis C virus replicon by adenovirus vector-mediated expression of tough decoy RNA against miR-122a. -other hsa-mir-1-1 Colorectal Carcinoma 22343615 MicroRNA profiling in colorectal cancer highlights miR-1 involvement in MET-dependent proliferation. -other hsa-mir-31 Pancreatic Neoplasms 22344632 Both inhibition and enhanced expression of miR-31 lead to reduced migration and invasion of pancreatic cancer cells. -other hsa-mir-21 Renal Fibrosis 22344686 MicroRNA-21 Promotes Fibrosis of the Kidney by Silencing Metabolic Pathways. -other hsa-mir-21 Kidney Neoplasms 22347428 Up-Regulation of MicroRNA-21 Correlates with Lower Kidney Cancer Survival. -other hsa-mir-197 Thyroid Neoplasms 22351693 "A SVM model with 4 miRNAs (miR-222, miR-328, miR-197 and miR-21) was initially estimated to have 86% predictive accuracy using cross-validation to differentiate Malignant from Benign." -other hsa-mir-21 Thyroid Neoplasms 22351693 "A SVM model with 4 miRNAs (miR-222, miR-328, miR-197 and miR-21) was initially estimated to have 86% predictive accuracy using cross-validation to differentiate Malignant from Benign." -other hsa-mir-222 Thyroid Neoplasms 22351693 "A SVM model with 4 miRNAs (miR-222, miR-328, miR-197 and miR-21) was initially estimated to have 86% predictive accuracy using cross-validation to differentiate Malignant from Benign." -other hsa-mir-328 Thyroid Neoplasms 22351693 "A SVM model with 4 miRNAs (miR-222, miR-328, miR-197 and miR-21) was initially estimated to have 86% predictive accuracy using cross-validation to differentiate Malignant from Benign." -other hsa-mir-128b Lung Neoplasms 22352917 "Among them, 11 miRNAs including miR-7 and miR-128b were confirmed by published experimental data or literatures." -other hsa-mir-7 Lung Neoplasms 22352917 "Among them, 11 miRNAs including miR-7 and miR-128b were confirmed by published experimental data or literatures." -other hsa-mir-101-1 Colon Neoplasms 22353936 MicroRNA-101 (miR-101) post-transcriptionally regulates the expression of EP4 receptor in colon cancers. -other hsa-mir-101-2 Colon Neoplasms 22353936 MicroRNA-101 (miR-101) post-transcriptionally regulates the expression of EP4 receptor in colon cancers. -other hsa-mir-21 "Aortic Aneurysm, Abdominal" 22357537 MicroRNA-21 Blocks Abdominal Aortic Aneurysm Development and Nicotine-Augmented Expansion. -other hsa-mir-196a-1 Keloid 22358059 miR-196a Downregulation Increases the Expression of Type I and III Collagens in Keloid Fibroblasts. -other hsa-mir-196a-2 Keloid 22358059 miR-196a Downregulation Increases the Expression of Type I and III Collagens in Keloid Fibroblasts. -other hsa-mir-941-1 "Colitis, Ulcerative" 22359580 UC susceptibility -other hsa-mir-941-3 "Colitis, Ulcerative" 22359580 UC susceptibility -other hsa-mir-941-4 "Colitis, Ulcerative" 22359580 UC susceptibility -other hsa-mir-1-1 Heart Failure 22362515 SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway. -other hsa-mir-1-2 Heart Failure 22362515 SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway. -other hsa-mir-132 Inflammation 22362752 we propose an outline of the current knowledge about miR-132 and miR-212 functions in neurons and immune cells -other hsa-mir-212 Inflammation 22362752 we propose an outline of the current knowledge about miR-132 and miR-212 functions in neurons and immune cells -other hsa-mir-148b Glomerulonephritis 22362909 Abnormal miR-148b Expression Promotes Aberrant Glycosylation of IgA1 in IgA Nephropathy. -other hsa-mir-146a Prion Diseases 22363497 MicroRNA 146a (miR-146a) Is Over-Expressed during Prion Disease and Modulates the Innate Immune Response and the Microglial Activation State. -other hsa-mir-200c Breast Neoplasms 22364742 IL6-Mediated Suppression of miR-200c Directs Constitutive Activation of Inflammatory Signaling Circuit Driving Transformation and Tumorigenesis. -other hsa-mir-142 Hypertrophy 22367739 Repression of miR-142 by p300 and MAPK is required for survival signaling via gp130 during adaptive hypertrophy. -other hsa-mir-124-1 "Carcinoma, Lung, Non-Small-Cell" 22370637 "The authors found a number of miRNAs (miR-17, miR-135, miR-520, miR-124-1, and miR-34c) that may rescue cell viability from caspase-8 activation." -other hsa-mir-135a-1 "Carcinoma, Lung, Non-Small-Cell" 22370637 "The authors found a number of miRNAs (miR-17, miR-135, miR-520, miR-124-1, and miR-34c) that may rescue cell viability from caspase-8 activation." -other hsa-mir-135a-2 "Carcinoma, Lung, Non-Small-Cell" 22370637 "The authors found a number of miRNAs (miR-17, miR-135, miR-520, miR-124-1, and miR-34c) that may rescue cell viability from caspase-8 activation." -other hsa-mir-135b "Carcinoma, Lung, Non-Small-Cell" 22370637 "The authors found a number of miRNAs (miR-17, miR-135, miR-520, miR-124-1, and miR-34c) that may rescue cell viability from caspase-8 activation." -other hsa-mir-17 "Carcinoma, Lung, Non-Small-Cell" 22370637 "The authors found a number of miRNAs (miR-17, miR-135, miR-520, miR-124-1, and miR-34c) that may rescue cell viability from caspase-8 activation." -other hsa-mir-520a "Carcinoma, Lung, Non-Small-Cell" 22370637 "The authors found a number of miRNAs (miR-17, miR-135, miR-520, miR-124-1, and miR-34c) that may rescue cell viability from caspase-8 activation." -other hsa-mir-520b "Carcinoma, Lung, Non-Small-Cell" 22370637 "The authors found a number of miRNAs (miR-17, miR-135, miR-520, miR-124-1, and miR-34c) that may rescue cell viability from caspase-8 activation." -other hsa-mir-520c "Carcinoma, Lung, Non-Small-Cell" 22370637 "The authors found a number of miRNAs (miR-17, miR-135, miR-520, miR-124-1, and miR-34c) that may rescue cell viability from caspase-8 activation." -other hsa-mir-520d "Carcinoma, Lung, Non-Small-Cell" 22370637 "The authors found a number of miRNAs (miR-17, miR-135, miR-520, miR-124-1, and miR-34c) that may rescue cell viability from caspase-8 activation." -other hsa-mir-520e "Carcinoma, Lung, Non-Small-Cell" 22370637 "The authors found a number of miRNAs (miR-17, miR-135, miR-520, miR-124-1, and miR-34c) that may rescue cell viability from caspase-8 activation." -other hsa-mir-152 Atherosclerosis 22370758 Co-expression in plaque tissue and classical monocytes. -other hsa-mir-422a Atherosclerosis 22370758 Co-expression in plaque tissue and non-classical monocytes. -other hsa-mir-99b Atherosclerosis 22370758 Co-expression in plaque tissue and classical monocytes. -other hsa-mir-146a Inflammation 22371089 miR-146a and miR-147 are involved in the resolution phase of inflammation. -other hsa-mir-147 Inflammation 22371089 miR-146a and miR-147 are involved in the resolution phase of inflammation. -other hsa-mir-21 Hypertension 22371328 MicroRNA-21 Integrates Pathogenic Signaling to Control Pulmonary Hypertension -other hsa-mir-493 Colon Neoplasms 22373578 miR-493 induction during carcinogenesis blocks metastatic settlement of colon cancer cells in liver. -other hsa-mir-143 Atherosclerosis 22373869 Secreted miRNAs (miR-143/145) suppress atherogenesis. -other hsa-mir-145 Atherosclerosis 22373869 Secreted miRNAs (miR-143/145) suppress atherogenesis. -other hsa-mir-146a Rheumatoid Arthritis 22374446 "In 2008, miR-146a and miR-155 were reported to be involved in the pathology of rheumatoid arthritis." -other hsa-mir-155 Rheumatoid Arthritis 22374446 "In 2008, miR-146a and miR-155 were reported to be involved in the pathology of rheumatoid arthritis." -other hsa-mir-145 "Carcinoma, Hepatocellular" 22378186 Tumorigenicity of cancer stem-like cells derived from hepatocarcinoma is regulated by microRNA-145. -other hsa-mir-26a-1 Breast Neoplasms 22384020 Trastuzumab Produces Therapeutic Actions by Upregulating miR-26a and miR-30b in Breast Cancer Cells. -other hsa-mir-26a-2 Breast Neoplasms 22384020 Trastuzumab Produces Therapeutic Actions by Upregulating miR-26a and miR-30b in Breast Cancer Cells. -other hsa-mir-30b Breast Neoplasms 22384020 Trastuzumab Produces Therapeutic Actions by Upregulating miR-26a and miR-30b in Breast Cancer Cells. -other hsa-mir-302b Colon Neoplasms 22384170 Ascl2 Knockdown Results in Tumor Growth Arrest by miRNA-302b-Related Inhibition of Colon Cancer Progenitor Cells. -other hsa-let-7b Hepatitis C Virus Infection 22391672 Let-7b is a novel regulator of hepatitis C virus replication. -other hsa-mir-146b Obesity 22393448 Decrease of miR-146b-5p in Monocytes during Obesity Is Associated with Loss of the Anti-Inflammatory but Not Insulin Signaling Action of Adiponectin. -other hsa-mir-376b Myocardial Ischemic-Reperfusion Injury 22396777 M(3) Subtype of Muscarinic Acetylcholine Receptor Promotes Cardioprotection via the Suppression of miR-376b-5p. -other hsa-mir-29b-1 "Carcinoma, Lung, Non-Small-Cell" 22399498 increased after necitumumab in combination with cisplatin/gemcitabine -other hsa-mir-29b-2 "Carcinoma, Lung, Non-Small-Cell" 22399498 increased after necitumumab in combination with cisplatin/gemcitabine -other hsa-mir-29b-1 Prostate Neoplasms 22402125 MicroRNA-29b Suppresses Prostate Cancer Metastasis by Regulating Epithelial-Mesenchymal Transition Signaling. -other hsa-mir-29b-2 Prostate Neoplasms 22402125 MicroRNA-29b Suppresses Prostate Cancer Metastasis by Regulating Epithelial-Mesenchymal Transition Signaling. -other hsa-mir-133a-1 Atrial Fibrillation 22407060 both miR-133 and miR-30 play an important role in controlling structural changes in chronic AF -other hsa-mir-133a-2 Atrial Fibrillation 22407060 both miR-133 and miR-30 play an important role in controlling structural changes in chronic AF -other hsa-mir-133b Atrial Fibrillation 22407060 both miR-133 and miR-30 play an important role in controlling structural changes in chronic AF -other hsa-mir-30a Atrial Fibrillation 22407060 both miR-133 and miR-30 play an important role in controlling structural changes in chronic AF -other hsa-mir-30b Atrial Fibrillation 22407060 both miR-133 and miR-30 play an important role in controlling structural changes in chronic AF -other hsa-mir-30c-1 Atrial Fibrillation 22407060 both miR-133 and miR-30 play an important role in controlling structural changes in chronic AF -other hsa-mir-30c-2 Atrial Fibrillation 22407060 both miR-133 and miR-30 play an important role in controlling structural changes in chronic AF -other hsa-mir-30d Atrial Fibrillation 22407060 both miR-133 and miR-30 play an important role in controlling structural changes in chronic AF -other hsa-mir-126 Inflammation 22419694 MicroRNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation. -other hsa-mir-223 "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 22424712 Notch-mediated repression of miR-223 contributes to IGF1R regulation in T-ALL. -other hsa-mir-145 "Carcinoma, Hepatocellular" 22431718 MiR-145 modulates multiple components of the insulin-like growth factor pathway in hepatocellular carcinoma. -other hsa-mir-192 "Carcinoma, Hepatocellular" 22433310 HBx gene down-regulates miR-192 expression and inhibits apoptosis of human hepatoma cell line HepG2. -other hsa-mir-103 Metabolic Syndrome 22436747 "Other metabolic miRNAs, such as miR-103 and miR-107, regulate insulin and glucose homeostasis, whereas miRNAs such as miR-34a are emerging as key regulators of hepatic lipid homeostasis." -other hsa-mir-107 Metabolic Syndrome 22436747 "Other metabolic miRNAs, such as miR-103 and miR-107, regulate insulin and glucose homeostasis, whereas miRNAs such as miR-34a are emerging as key regulators of hepatic lipid homeostasis." -other hsa-mir-33a Metabolic Syndrome 22436747 "miR-33a and miR-33b have a crucial role in controlling cholesterol and lipid metabolism in concert with their host genes, the sterol-regulatory element-binding protein (SREBP) transcription factors." -other hsa-mir-33b Metabolic Syndrome 22436747 "miR-33a and miR-33b have a crucial role in controlling cholesterol and lipid metabolism in concert with their host genes, the sterol-regulatory element-binding protein (SREBP) transcription factors." -other hsa-mir-34a Metabolic Syndrome 22436747 "Other metabolic miRNAs, such as miR-103 and miR-107, regulate insulin and glucose homeostasis, whereas miRNAs such as miR-34a are emerging as key regulators of hepatic lipid homeostasis." -other hsa-mir-193a Prostate Neoplasms 22438885 miR-193a-3p and miRPlus-E1245 observed to be specific to XMRV infection in all 4 cell types (Two prostate cell lines (LNCaP and DU145) and two primary cells). -other hsa-mir-34b Breast Neoplasms 22439831 "MiR-34b is associated with clinical outcome in triple-negative breast cancer patients.Expression levels of miR-34b significantly correlate with disease free survival (DFS) (p = 0.0020, log-rank test) and overall survival (OS) (p = 0.0008, log-rank test) of TNBC patients." -other hsa-mir-421 "Carcinoma, Hepatocellular" 22446874 Downregulation of Human Farnesoid X Receptor by miR-421 Promotes Proliferation and Migration of Hepatocellular Carcinoma Cells. -other hsa-mir-25 Esophageal Neoplasms 22450326 MicroRNA-25 promotes cell migration and invasion in esophageal squamous cell carcinoma. -other hsa-mir-20a Hypertension 22450430 AntagomiR directed against miR-20a restores functional BMPR2 signalling and prevents vascular remodelling in hypoxia-induced pulmonary hypertension. -other hsa-let-7c Influenza 22452878 Cellular MicroRNA let-7c Inhibits M1 Protein Expression of the H1N1 Influenza A Virus in Infected Human Lung Epithelial Cells. -other hsa-mir-146a Neoplasms [unspecific] 22453030 In this review we focus on recent progress in analyzing the functional role of miR-146a in the control of normal and malignant hematopoiesis. -other hsa-mir-372 Colorectal Carcinoma 22456107 MicroRNA-372 Is Associated with Poor Prognosis in Colorectal Cancer. -other hsa-mir-125b Inflammation 22456625 "Targets of miR-125b include key proteins regulating apoptosis, innate immunity, inflammation and hematopoietic differentiation." -other hsa-mir-34a Osteosarcoma 22457788 MicroRNA-34a Inhibits the Proliferation and Metastasis of Osteosarcoma Cells Both In Vitro and In Vivo. -other hsa-mir-29a Liver Diseases [unspecific] 22469499 Hepatic miR-29ab1 expression modulates chronic hepatic injury. -other hsa-mir-29b-1 Liver Diseases [unspecific] 22469499 Hepatic miR-29ab1 expression modulates chronic hepatic injury. -other hsa-mir-29b-2 Liver Diseases [unspecific] 22469499 Hepatic miR-29ab1 expression modulates chronic hepatic injury. -other hsa-mir-106a "Squamous Cell Carcinoma, Cerevial" 22472886 "The miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis." -other hsa-mir-143 "Squamous Cell Carcinoma, Cerevial" 22472886 "The miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis." -other hsa-mir-145 "Squamous Cell Carcinoma, Cerevial" 22472886 "The miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis." -other hsa-mir-15a "Squamous Cell Carcinoma, Cerevial" 22472886 "The miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis." -other hsa-mir-16-1 "Squamous Cell Carcinoma, Cerevial" 22472886 "The miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis." -other hsa-mir-16-2 "Squamous Cell Carcinoma, Cerevial" 22472886 "The miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis." -other hsa-mir-18b "Squamous Cell Carcinoma, Cerevial" 22472886 "The miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis." -other hsa-mir-195 "Squamous Cell Carcinoma, Cerevial" 22472886 "The miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis." -other hsa-mir-19b-2 "Squamous Cell Carcinoma, Cerevial" 22472886 "The miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis." -other hsa-mir-20b "Squamous Cell Carcinoma, Cerevial" 22472886 "The miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis." -other hsa-mir-363 "Squamous Cell Carcinoma, Cerevial" 22472886 "The miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis." -other hsa-mir-497 "Squamous Cell Carcinoma, Cerevial" 22472886 "The miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis." -other hsa-mir-92a-2 "Squamous Cell Carcinoma, Cerevial" 22472886 "The miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis." -other hsa-mir-103a-1 Pancreatic Neoplasms 22479426 "The driving miRNAs were miR-103, miR-23a and miR-15b in pancreatic cancers." -other hsa-mir-103a-2 Pancreatic Neoplasms 22479426 "The driving miRNAs were miR-103, miR-23a and miR-15b in pancreatic cancers." -other hsa-mir-103b-1 Pancreatic Neoplasms 22479426 "The driving miRNAs were miR-103, miR-23a and miR-15b in pancreatic cancers." -other hsa-mir-103b-2 Pancreatic Neoplasms 22479426 "The driving miRNAs were miR-103, miR-23a and miR-15b in pancreatic cancers." -other hsa-mir-1246 Colorectal Carcinoma 22479426 "The driving miRNAs were miR-195, miR-1280, miR-140-3p and miR-1246 in colorectal tumors." -other hsa-mir-1280 Colorectal Carcinoma 22479426 "The driving miRNAs were miR-195, miR-1280, miR-140-3p and miR-1246 in colorectal tumors." -other hsa-mir-140 Colorectal Carcinoma 22479426 "The driving miRNAs were miR-195, miR-1280, miR-140-3p and miR-1246 in colorectal tumors." -other hsa-mir-15b Pancreatic Neoplasms 22479426 "The driving miRNAs were miR-103, miR-23a and miR-15b in pancreatic cancers." -other hsa-mir-195 Colorectal Carcinoma 22479426 "The driving miRNAs were miR-195, miR-1280, miR-140-3p and miR-1246 in colorectal tumors." -other hsa-mir-23a Pancreatic Neoplasms 22479426 "The driving miRNAs were miR-103, miR-23a and miR-15b in pancreatic cancers." -other hsa-mir-92a Breast Neoplasms 22482439 We found that miR-221 levels are prognostic in breast cancer illustrating the high-throughput method and confirming that miRNAs can be valuable biomarkers in cancer. -other hsa-mir-122 "Diabetes Mellitus, Type 2" 22488426 "Recent studies have shown key roles for miR-33 and miR-122 in regulation of lipid metabolism, and further evidence implicates miR-370 in regulation of miR-122." -other hsa-mir-33 "Diabetes Mellitus, Type 2" 22488426 "Recent studies have shown key roles for miR-33 and miR-122 in regulation of lipid metabolism, and further evidence implicates miR-370 in regulation of miR-122." -other hsa-mir-370 "Diabetes Mellitus, Type 2" 22488426 "Recent studies have shown key roles for miR-33 and miR-122 in regulation of lipid metabolism, and further evidence implicates miR-370 in regulation of miR-122." -other hsa-mir-143 Glioblastoma 22490015 Serial selection for invasiveness increases expression of miR-143/miR-145 in glioblastoma cell lines. -other hsa-mir-145 Glioblastoma 22490015 Serial selection for invasiveness increases expression of miR-143/miR-145 in glioblastoma cell lines. -other hsa-mir-107 Head And Neck Neoplasms 22491216 Lipid-based Nanoparticle Delivery of Pre-miR-107 Inhibits the Tumorigenicity of Head and Neck Squamous Cell Carcinoma. -other hsa-mir-193b "Carcinoma, Lung, Non-Small-Cell" 22491710 "MicroRNA-193b modulates proliferation, migration, and invasion of non-small cell lung cancer cells." -other hsa-mir-127 "Carcinoma, Renal Cell" 22492545 "miR-127-3p, miR-145, and miR-126 are significantly correlated with relapse-free survival of nonmetastatic RCC patients." -other hsa-mir-142 "Leukemia, Myeloid, Acute" 22493297 MicroRNA-29a and microRNA-142-3p are regulators of myeloid differentiation and acute myeloid leukemia. -other hsa-mir-29a "Leukemia, Myeloid, Acute" 22493297 MicroRNA-29a and microRNA-142-3p are regulators of myeloid differentiation and acute myeloid leukemia. -other hsa-mir-214 "Carcinoma, Lung, Non-Small-Cell" 22502680 MicroRNA-214 Regulates the Acquired Resistance to Gefitinib via the PTEN/AKT Pathway in EGFR-mutant Cell Lines. -other hsa-mir-125 Leukemia 22504525 Here we discuss new findings concerning PU.1-controlled microRNAs and miR-125-regulated networks in normal and malignant myelopoiesis. -other hsa-mir-181b Pancreatic Neoplasms 22504911 "miR-181b and miR-210 discriminatedPCa from normal individuals with receiver operating characteristic (ROC) curves and area under curve (AUC-ROC) of 0.745 and 0.772, respectively." -other hsa-mir-143 Prostate Neoplasms 22505520 The authors experientially validated the miRNA-KLK interaction by transfecting miR-331-3p and miR-143 into a PCa cell line. -other hsa-mir-331 Prostate Neoplasms 22505520 The authors experientially validated the miRNA-KLK interaction by transfecting miR-331-3p and miR-143 into a PCa cell line. -other hsa-mir-375 Breast Neoplasms 22508479 Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer. -other hsa-mir-34a "Lymphoma, Large B-Cell, Diffuse" 22522790 Systemic microRNA-34a delivery induces apoptosis and abrogates growth of diffuse large B-cell lymphoma in vivo. -other hsa-mir-125b Human Immunodeficiency Virus Infection 22527633 "Researchers have recently demonstrated the presence of anti-HIV-1 microRNAs (miR-28, miR-125b, miR-150, miR-223, and miR-382) in monocytes, macrophages, and CD4+ T cells, which are the primary targets of HIV infection." -other hsa-mir-150 Human Immunodeficiency Virus Infection 22527633 "Researchers have recently demonstrated the presence of anti-HIV-1 microRNAs (miR-28, miR-125b, miR-150, miR-223, and miR-382) in monocytes, macrophages, and CD4+ T cells, which are the primary targets of HIV infection." -other hsa-mir-223 Human Immunodeficiency Virus Infection 22527633 "Researchers have recently demonstrated the presence of anti-HIV-1 microRNAs (miR-28, miR-125b, miR-150, miR-223, and miR-382) in monocytes, macrophages, and CD4+ T cells, which are the primary targets of HIV infection." -other hsa-mir-28 Human Immunodeficiency Virus Infection 22527633 "Researchers have recently demonstrated the presence of anti-HIV-1 microRNAs (miR-28, miR-125b, miR-150, miR-223, and miR-382) in monocytes, macrophages, and CD4+ T cells, which are the primary targets of HIV infection." -other hsa-mir-382 Human Immunodeficiency Virus Infection 22527633 "Researchers have recently demonstrated the presence of anti-HIV-1 microRNAs (miR-28, miR-125b, miR-150, miR-223, and miR-382) in monocytes, macrophages, and CD4+ T cells, which are the primary targets of HIV infection." -other hsa-mir-21 Glioblastoma 22528454 MicroRNA-21 inhibitor sensitizes human glioblastoma U251 stem cells to chemotherapeutic drug temozolomide. -other hsa-mir-21 Heart Failure 22529925 Transfection assay revealed that both Ago1 and Ago2 synergistically induced miR-21 and miR-21* when the mir-21 plasmid was co-transfected with either. -other hsa-mir-204 Hypertension 22534459 "This correlates with a down-regulation of miR-204 as well as an up-regulation of miR-21 in PLs, which in turn corresponds to enhanced cell proliferation." -other hsa-mir-21 Hypertension 22534459 "This correlates with a down-regulation of miR-204 as well as an up-regulation of miR-21 in PLs, which in turn corresponds to enhanced cell proliferation." -other hsa-mir-375 Colorectal Carcinoma 22535378 "In formalin-fixed paraffin-embedded surgical tissue samples, a combination of miR-375, miR-424 and miR-92a yielded an accuracy of 94% (AUC=0.968) in discriminating carcinomas from adenomas. " -other hsa-mir-424 Colorectal Carcinoma 22535378 "In formalin-fixed paraffin-embedded surgical tissue samples, a combination of miR-375, miR-424 and miR-92a yielded an accuracy of 94% (AUC=0.968) in discriminating carcinomas from adenomas. " -other hsa-mir-92a Colorectal Carcinoma 22535378 "In formalin-fixed paraffin-embedded surgical tissue samples, a combination of miR-375, miR-424 and miR-92a yielded an accuracy of 94% (AUC=0.968) in discriminating carcinomas from adenomas. " -other hsa-mir-206 Rhabdomyosarcoma 22541669 miR-206 integrates multiple components of differentiation pathways to control the transition from growth to differentiation in rhabdomyosarcoma cells. -other hsa-mir-125b Heart Failure 22545159 "These studies identified miR-125b as an important regulator of hESC differentiation in general, and the development of hESC-derived mesoderm and cardiac muscle in particular." -other hsa-mir-142 Systemic Lupus Erythematosus 22549634 Decreased miR-142-3p/5p expression causes CD4(+) T cell activation and B cell hyperstimulation in systemic lupus erythematosus. -other hsa-mir-126 "Carcinoma, Hepatocellular" 22552153 recurrence-related in hepatocellular carcinoma -other hsa-mir-147a "Carcinoma, Hepatocellular" 22552153 recurrence-related in hepatocellular carcinoma -other hsa-mir-19a "Carcinoma, Hepatocellular" 22552153 recurrence-related in hepatocellular carcinoma -other hsa-mir-223 "Carcinoma, Hepatocellular" 22552153 recurrence-related in hepatocellular carcinoma -other hsa-mir-24-1 "Carcinoma, Hepatocellular" 22552153 recurrence-related in hepatocellular carcinoma -other hsa-mir-24-2 "Carcinoma, Hepatocellular" 22552153 recurrence-related in hepatocellular carcinoma -other hsa-mir-708 Prostate Neoplasms 22552290 miRNA-708 control of CD44+ prostate cancer initiating cells. -other hsa-mir-21 Colorectal Carcinoma 22553926 "EGF/Ras efficiently induces the miR-21 primary transcript, but this does not rapidly and simply translate into higher mature miR-21 levels." -other hsa-mir-92a-1 Breast Neoplasms 22563438 Downregulation of miR-92a is associated with aggressive breast cancer features and increased tumour macrophage infiltration. -other hsa-mir-92a-2 Breast Neoplasms 22563438 Downregulation of miR-92a is associated with aggressive breast cancer features and increased tumour macrophage infiltration. -other hsa-mir-34a Glioma 22568628 MicroRNA-34a Suppresses Cell Proliferation and Induces Apoptosis in U87 Glioma Stem Cells. -other hsa-mir-22 Heart Failure 22570371 These data indicate that miR-22 functions as an integrator of Ca(2+) homeostasis and myofibrillar protein content during stress in the heart and shed light on the mechanisms that enhance propensity toward heart failure. -other hsa-mir-142 Glioblastoma 22570537 Integrated Analysis Reveals hsa-miR-142 as a Representative of a Lymphocyte-Specific Gene Expression and Methylation Signature. -other hsa-mir-145 Thrombocytosis 22571696 Recent evidence suggests that haploinsufficiency of the microRNA genes miR-145 and miR-146a may contribute to the thrombocytosis seen in the 5q- syndrome. -other hsa-mir-146a Thrombocytosis 22571696 Recent evidence suggests that haploinsufficiency of the microRNA genes miR-145 and miR-146a may contribute to the thrombocytosis seen in the 5q- syndrome. -other hsa-mir-221 Asthma 22572970 Inhibition of miRNA-221 Suppresses the Airway Inflammation in Asthma. -other hsa-mir-15a Colon Neoplasms 22574716 Vector-based miR-15a/16-1 plasmid inhibits colon cancer growth in vivo. -other hsa-mir-16-1 Colon Neoplasms 22574716 Vector-based miR-15a/16-1 plasmid inhibits colon cancer growth in vivo. -other hsa-mir-15a Immune System Disease [unspecific] 22578383 "In conclusion, our data support the involvement of elevated miR-15a in autoimmune disease development in B/W mice and suggest that decreasing this microRNA might be beneficial in B/W mice." -other hsa-mir-205 Breast Neoplasms 22578566 Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. -other hsa-mir-146a Asthma 22580216 "These observations suggest that microRNA-181a, -146a and -146b are proinflammatory factors in asthma, and that down-regulation of miRNA-146a may partially account for the anti-inflammatory effect of dexamethasone." -other hsa-mir-146b Asthma 22580216 "These observations suggest that microRNA-181a, -146a and -146b are proinflammatory factors in asthma, and that down-regulation of miRNA-146a may partially account for the anti-inflammatory effect of dexamethasone." -other hsa-mir-181a Asthma 22580216 "These observations suggest that microRNA-181a, -146a and -146b are proinflammatory factors in asthma, and that down-regulation of miRNA-146a may partially account for the anti-inflammatory effect of dexamethasone." -other hsa-mir-21 Cardiac Fibrosis 22580345 "we identify the protective transcriptome signature of enhanced PI3K¦Á signaling in the context of pathological hypertrophy, and demonstrate the regulation of TGF-¦Â/miR-21 by which enhanced PI3K¦Á signaling protects against cardiac fibrosis." -other hsa-mir-502 Colon Neoplasms 22580605 Inhibition of autophagy and tumor growth in colon cancer by miR-502. -other hsa-mir-9 Immune System Disease [unspecific] 22585398 "Using microarray and deep sequencing approaches, we detected an increase in the abundance of miR-9 in activated human CD4(+) T cells." -other hsa-mir-122 Hepatitis C Virus Infection 22593164 Expression of MicroRNA miR-122 Facilitates an Efficient Replication in Nonhepatic Cells upon Infection with Hepatitis C Virus. -other hsa-mir-155 "Lymphoma, Large B-Cell, Diffuse" 22609116 miR-155 Regulates the PI3K-AKT pathway in diffuse large B-cell lymphoma. -other hsa-mir-106b Myocardial Infarction 22613985 MiR-106b and MiR-15b modulate apoptosis and angiogenesis in myocardial infarction. -other hsa-let-7g Obesity 22614057 "Maternal obesity downregulates microRNA let-7g expression, a possible mechanism for enhanced adipogenesis during ovine fetal skeletal muscle development." -other hsa-mir-30a "Leukemia, Myeloid, Chronic" 22617440 microRNA 30A promotes autophagy in response to cancer therapy. -other hsa-mir-21 Breast Neoplasms 22618231 "Regulatory interplay between miR-21, JAG1 and 17beta-estradiol (E2) in breast cancer cells." -other hsa-mir-23a Colorectal Carcinoma 22628407 miR-23a promotes the transition from indolent to invasive colorectal cancer. -other hsa-mir-204 Breast Neoplasms 22629385 "Gene expression analysis of miR-204 and miR-379-transfected cells indicated that these miRNAs downregulated the expression of several genes involved in TGF-¦Â signaling, including prostaglandin-endoperoxide synthase 2 (PTGS2)." -other hsa-mir-379 Breast Neoplasms 22629385 "Gene expression analysis of miR-204 and miR-379-transfected cells indicated that these miRNAs downregulated the expression of several genes involved in TGF-¦Â signaling, including prostaglandin-endoperoxide synthase 2 (PTGS2)." -other hsa-mir-499a "Carcinoma, Hepatocellular" 22641068 Histone Deacetylases Activate Hepatocyte Growth Factor Signaling by Repressing MicroRNA-449 in Hepatocellular Carcinoma Cells. -other hsa-mir-499b "Carcinoma, Hepatocellular" 22641068 Histone Deacetylases Activate Hepatocyte Growth Factor Signaling by Repressing MicroRNA-449 in Hepatocellular Carcinoma Cells. -other hsa-let-7 Diffuse Lipomatosis 22642449 First description of inhibition of let-7 microRNA expression and HMGA2 overexpression in a case of deep-seated diffuse lipomatosis. -other hsa-mir-107 "Diabetes Mellitus, Type 2" 22645244 miR-107: a Toll-like receptor-regulated miRNA dysregulated in obesity and type II diabetes. -other hsa-mir-107 Obesity 22645244 miR-107: a Toll-like receptor-regulated miRNA dysregulated in obesity and type II diabetes. -other hsa-mir-20a Endometriosis 22648654 Hypoxia-induced microRNA-20a expression increases ERK phosphorylation and angiogenic gene expression in endometriotic stromal cells. -other hsa-mir-34a Cardiovascular Diseases [unspecific] 22651868 Micro-RNA-34a contributes to the impaired function of bone marrow-derived mononuclear cells from patients with cardiovascular disease. -other hsa-mir-31 Lung Fibrosis 22661007 miR-31 is a negative regulator of fibrogenesis and pulmonary fibrosis. -other hsa-mir-34a Neuroblastoma 22662276 Inhibition of neuroblastoma tumor growth by targeted delivery of microRNA-34a using anti-disialoganglioside GD2 coated nanoparticles. -other hsa-mir-9-1 Head And Neck Neoplasms 22664743 IRS-1 suppresses metastasis of head and neck cancer possibly through miR-9 -other hsa-mir-9-2 Head And Neck Neoplasms 22664743 IRS-1 suppresses metastasis of head and neck cancer possibly through miR-9 -other hsa-mir-9-3 Head And Neck Neoplasms 22664743 IRS-1 suppresses metastasis of head and neck cancer possibly through miR-9 -other hsa-mir-193b Melanoma 22665054 "Taken together, our study suggests that downregulation of miR-193b may contribute to increased STMN1 expression in melanoma, which consequently promotes migration and proliferation of tumor cells." -other hsa-mir-208a Hypertension 22666483 "this work reveals an original aldosterone-dependent inhibition of miR-208a in hypertension, resulting in the inhibition of ¦Â-myosin heavy chain expression through the induction of its transcriptional repressor Sox6." -other hsa-mir-208b Hypertension 22666483 "Besides, the AH-induced increase of ?MyHC and its intronic miRNA-208b was prevented in AS-Ren." -other hsa-mir-210 Pancreatic Neoplasms 22672828 "miR-210 expression in PC cells is induced by hypoxia through a HIF-1alpha-dependent pathway, but does not influence PC cell proliferation." -other hsa-mir-17 Colon Neoplasms 22677902 "miR-21, miR-17 and miR-19a induced by phosphatase of regenerating liver-3 promote the proliferation and metastasis of colon cancer." -other hsa-mir-19a Colon Neoplasms 22677902 "miR-21, miR-17 and miR-19a induced by phosphatase of regenerating liver-3 promote the proliferation and metastasis of colon cancer." -other hsa-mir-21 Colon Neoplasms 22677902 "miR-21, miR-17 and miR-19a induced by phosphatase of regenerating liver-3 promote the proliferation and metastasis of colon cancer." -other hsa-mir-155 "Leukemia, Myeloid, Acute" 22681934 MiR-424 and miR-155 deregulated expression in cytogenetically normal acute myeloid leukaemia: correlation with NPM1 and FLT3 mutation status. -other hsa-mir-424 "Leukemia, Myeloid, Acute" 22681934 MiR-424 and miR-155 deregulated expression in cytogenetically normal acute myeloid leukaemia: correlation with NPM1 and FLT3 mutation status. -other hsa-mir-10b Choriocarcinoma 22682079 The role of miR-10b in metastatic pancreatic ductal adenocarcinoma. -other hsa-mir-376a-1 "Carcinoma, Hepatocellular" 22684007 miR-376a suppresses proliferation and induces apoptosis in hepatocellular carcinoma. -other hsa-mir-376a-2 "Carcinoma, Hepatocellular" 22684007 miR-376a suppresses proliferation and induces apoptosis in hepatocellular carcinoma. -other hsa-mir-23a Colorectal Carcinoma 22684455 "miR-23a, a critical regulator of migRation and metastasis in colorectal cancer." -other hsa-mir-21 Esophageal Neoplasms 22689922 Dysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer. -other hsa-mir-31 Esophageal Neoplasms 22689922 Dysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer. -other hsa-mir-124 Glioblastoma 22701651 "Significantly, REST is highly expressed in self-renewing tumorigenic-competent GBM cells and its knock down strongly reduces their self-renewal in vitro and tumor-initiating capacity in vivo and affects levels of miR-124 and its downstream targets." -other hsa-mir-31 Esophageal Neoplasms 22706599 MicroRNA-31 modulates tumour sensitivity to radiation in oesophageal adenocarcinoma. -other hsa-mir-200c Cholangiocarcinoma 22707408 "Inactivation of miR-200c resulted in an induction of EMT, whereas activation of miR-200c led to a reduction of EMT including a reduced cell migration and invasion in ICC cells." -other hsa-mir-125b-1 Glioblastoma 22711523 miR-125b expression plays an essential role in the invasion of glioblastoma CD133-positive cells but not CD133-negative cells. -other hsa-mir-125b-2 Glioblastoma 22711523 miR-125b expression plays an essential role in the invasion of glioblastoma CD133-positive cells but not CD133-negative cells. -other hsa-mir-29b-1 Preeclampsia 22716646 "MicroRNA-29b contributes to pre-eclampsia through its effects on apoptosis, invasion and angiogenesis of trophoblast cells." -other hsa-mir-29b-2 Preeclampsia 22716646 "MicroRNA-29b contributes to pre-eclampsia through its effects on apoptosis, invasion and angiogenesis of trophoblast cells." -other hsa-mir-31 Oral Leukoplakia 22719913 Upregulation of miR-31* is negatively associated with recurrent/newly formed oral leukoplakia. -other hsa-mir-196b Glioblastoma 22723849 Upregulation of miR-196b confers a poor prognosis in glioblastoma patients via inducing a proliferative phenotype. -other hsa-mir-200c Colorectal Carcinoma 22735571 MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis. -other hsa-mir-31 Systemic Lupus Erythematosus 22736314 microRNA-31 is a novel regulator contributing to impaired IL-2 production in T cells from patients with systemic lupus erythematosus. -other hsa-mir-101 Bladder Neoplasms 22745731 "The combination of four (miR-101, miR-125a-5p, miR-148b, and miR-151-5p) or three (miR-148b, miR-181b, and miR-874,) reference miRNAs is recommended for normalization." -other hsa-mir-125a Bladder Neoplasms 22745731 "The combination of four (miR-101, miR-125a-5p, miR-148b, and miR-151-5p) or three (miR-148b, miR-181b, and miR-874,) reference miRNAs is recommended for normalization." -other hsa-mir-148b Bladder Neoplasms 22745731 "The combination of four (miR-101, miR-125a-5p, miR-148b, and miR-151-5p) or three (miR-148b, miR-181b, and miR-874,) reference miRNAs is recommended for normalization." -other hsa-mir-151 Bladder Neoplasms 22745731 "The combination of four (miR-101, miR-125a-5p, miR-148b, and miR-151-5p) or three (miR-148b, miR-181b, and miR-874,) reference miRNAs is recommended for normalization." -other hsa-mir-181b Bladder Neoplasms 22745731 "The combination of four (miR-101, miR-125a-5p, miR-148b, and miR-151-5p) or three (miR-148b, miR-181b, and miR-874,) reference miRNAs is recommended for normalization." -other hsa-mir-874 Bladder Neoplasms 22745731 "The combination of four (miR-101, miR-125a-5p, miR-148b, and miR-151-5p) or three (miR-148b, miR-181b, and miR-874,) reference miRNAs is recommended for normalization." -other hsa-mir-499 Heart Failure 22752967 "miR-499 is increased in human and murine cardiac hypertrophy and cardiomyopathy, is sufficient to cause murine heart failure, and accelerates maladaptation to pressure overloading. " -other hsa-mir-103 Breast Neoplasms 22753153 Identification of fifteen novel germline variants in the BRCA1 3'UTR reveals a variant in a breast cancer case that introduces a functional miR-103 target site. -other hsa-mir-21 Glioblastoma 22753745 MicroRNA-21 inhibition enhances in vitro chemosensitivity of temozolomide-resistant glioblastoma cells. -other hsa-mir-21 Myocardial Infarction 22760500 Activation of Rac1 by angiotensin II leads to a CTGF- and lysyl oxidase-mediated increase of miR-21 expression contributing to structural remodelling of the atrial myocardium. -other hsa-mir-21 "Carcinoma, Oral" 22761427 Keratinization-associated miR-7 and miR-21 Regulate Tumor Suppressor Reversion-inducing Cysteine-rich Protein with Kazal Motifs (RECK) in Oral Cancer. -other hsa-mir-7-1 "Carcinoma, Oral" 22761427 Keratinization-associated miR-7 and miR-21 Regulate Tumor Suppressor Reversion-inducing Cysteine-rich Protein with Kazal Motifs (RECK) in Oral Cancer. -other hsa-mir-7-2 "Carcinoma, Oral" 22761427 Keratinization-associated miR-7 and miR-21 Regulate Tumor Suppressor Reversion-inducing Cysteine-rich Protein with Kazal Motifs (RECK) in Oral Cancer. -other hsa-mir-7-3 "Carcinoma, Oral" 22761427 Keratinization-associated miR-7 and miR-21 Regulate Tumor Suppressor Reversion-inducing Cysteine-rich Protein with Kazal Motifs (RECK) in Oral Cancer. -other hsa-mir-24-1 Pancreatic Neoplasms 22761894 "We investigated this possibility by analysis of miR-24-1 expression profiles in parathyroid adenomatous tissues from MEN1 gene mutation carriers, in their sporadic non-MEN1 counterparts, and in normal parathyroid tissue." -other hsa-mir-10b Glioma 22766763 Co-inhibition of microRNA-10b and microRNA-21 exerts synergistic inhibition on the proliferation and invasion of human glioma cells. -other hsa-mir-21 Glioma 22766763 Co-inhibition of microRNA-10b and microRNA-21 exerts synergistic inhibition on the proliferation and invasion of human glioma cells. -other hsa-mir-182 Endometrial Neoplasms 22766795 "In distinguishing endometrial endometrial carcinoma from complex atypical hyperplasia, the composite panel of four miRNAs (miR-182, 183, 200a, 200c) produced 95% sensitivity and 91% specificity." -other hsa-mir-183 Endometrial Neoplasms 22766795 "In distinguishing endometrial endometrial carcinoma from complex atypical hyperplasia, the composite panel of four miRNAs (miR-182, 183, 200a, 200c) produced 95% sensitivity and 91% specificity." -other hsa-mir-200a Endometrial Neoplasms 22766795 "In distinguishing endometrial endometrial carcinoma from complex atypical hyperplasia, the composite panel of four miRNAs (miR-182, 183, 200a, 200c) produced 95% sensitivity and 91% specificity." -other hsa-mir-200c Endometrial Neoplasms 22766795 "In distinguishing endometrial endometrial carcinoma from complex atypical hyperplasia, the composite panel of four miRNAs (miR-182, 183, 200a, 200c) produced 95% sensitivity and 91% specificity." -other hsa-mir-221 Thyroid Neoplasms 22771635 While a combination of miR-221 and 222 when used in a diagnostic panel could provide fairly good accuracy additional markers may need to be investigated to augment their diagnostic utility. -other hsa-mir-222 Thyroid Neoplasms 22771635 While a combination of miR-221 and 222 when used in a diagnostic panel could provide fairly good accuracy additional markers may need to be investigated to augment their diagnostic utility. -other hsa-mir-93 "Carcinoma, Hepatocellular" 22773266 Downregulation of MiR-93 Expression Reduces Cell Proliferation and Clonogenicity of HepG2 Cells. -other hsa-mir-15a Multiple Myeloma 22781767 BMSCs suppress the proliferation of myeloma cells and regulate the drug sensitivity of myeloma cells through the inhibited expression of miRNA-15a/-16. IL-6 plays a pivotal role in the occurrence of drug resistance. -other hsa-mir-16 Multiple Myeloma 22781767 BMSCs suppress the proliferation of myeloma cells and regulate the drug sensitivity of myeloma cells through the inhibited expression of miRNA-15a/-16. IL-6 plays a pivotal role in the occurrence of drug resistance. -other hsa-mir-494 Cholangiocarcinoma 22785131 Coordinated effects of microRNA-494 induce G/M arrest in human cholangiocarcinoma. -other hsa-mir-21 Ischemia-Reperfusion Injury 22785173 "Thus, upregulation of miR-21 contributes to the protective effect of delayed ischemic preconditioning against subsequent renal ischemia-reperfusion injury." -other hsa-mir-21 Bladder Neoplasms 22788411 "The effect of normalization was tested with miR-21 as the target gene, as this was previously suggested to be upregulated in cancer patients' serum." -other hsa-mir-155 Lung Neoplasms 22796123 "The present study demonstrated that intracellular miR-155 could be successfully and quickly detected by novel miR-155 MBs. As a noninvasive monitoring approach, MBs could be used to diagnose lung cancer at early stage through molecular imaging." -other hsa-mir-335 Gastric Neoplasms 22802949 A high frequency recurrence and poor survival were observed in GC cases with high level of hsa-miR-335 (P<0.001). -other hsa-mir-200b Colorectal Carcinoma 22804917 In KRAS mutated tumours increased miR-200b and decreased miR-143 expression were associated with a good progression-free survival . -other hsa-mir-34a "Leukemia, Myeloid, Acute" 22810507 "Clinically, low miR-34a expression and TP53 alterations predicted for chemotherapy resistance and inferior outcome. Notably, in TP53(unaltered) CK-AML, high miR-34a expression predicted for inferior overall survival (OS), whereas in TP53(biallelic altered) CK-AML, high miR-34a expression pointed to better OS." -other hsa-mir-101-1 Endomyocardial Fibrosis 22811578 MicroRNA-101 Inhibited Postinfarct Cardiac Fibrosis and Improved Left Ventricular Compliance via the FBJ Osteosarcoma Oncogene/Transforming Growth Factor Pathway. -other hsa-mir-101-2 Endomyocardial Fibrosis 22811578 MicroRNA-101 Inhibited Postinfarct Cardiac Fibrosis and Improved Left Ventricular Compliance via the FBJ Osteosarcoma Oncogene/Transforming Growth Factor-§Ø©ã Pathway. -other hsa-let-7i Ovarian Neoplasms 22812695 Our study indicated that this MUC1/let-7i chimera can specifically reverse chemoresistance to paclitaxel. -other hsa-mir-205 Prostate Neoplasms 22815235 "Additionally, for two genes that are deregulated in PCa (heterogeneous nuclear ribonucleoprotein K, hnRNP-K, and vascular endothelial growth factor A, VEGF-A), we identified two regulatory miRNAs, miR-205 and miR-29b." -other hsa-mir-29b Prostate Neoplasms 22815235 "Additionally, for two genes that are deregulated in PCa (heterogeneous nuclear ribonucleoprotein K, hnRNP-K, and vascular endothelial growth factor A, VEGF-A), we identified two regulatory miRNAs, miR-205 and miR-29b." -other hsa-mir-122 "Carcinoma, Hepatocellular" 22820284 "Knockout mice also displayed hepatic inflammation, fibrosis, and a high incidence of hepatocellular carcinoma, suggesting that miR-122 has a tumor suppressor role in hepatocytes." -other hsa-mir-125b "Carcinoma, Hepatocellular" 22824797 "downregulation of miR-125b was a frequent event in hepatocellular carcinoma (HCC) tissues, and the miR-125b level was positively associated with the rate of apoptosis in HCC tissues." -other hsa-mir-9-1 Melanoma 22825752 MicroRNA-9 suppresses uveal melanoma cell migration and invasion through the NF-kB1 pathway. -other hsa-mir-9-2 Melanoma 22825752 MicroRNA-9 suppresses uveal melanoma cell migration and invasion through the NF-kB1 pathway. -other hsa-mir-9-3 Melanoma 22825752 MicroRNA-9 suppresses uveal melanoma cell migration and invasion through the NF-kB1 pathway. -other hsa-mir-124 Glioblastoma 22829753 "Our follow up topological and functional analyses of the subnetwork revealed that six miRNAs (miR-124, miR-137, miR-219-5p, miR-34a, miR-9, and miR-92b) might play important roles in GBM, including some results that are supported by previous studies." -other hsa-mir-137 Glioblastoma 22829753 "Our follow up topological and functional analyses of the subnetwork revealed that six miRNAs (miR-124, miR-137, miR-219-5p, miR-34a, miR-9, and miR-92b) might play important roles in GBM, including some results that are supported by previous studies." -other hsa-mir-219 Glioblastoma 22829753 "Our follow up topological and functional analyses of the subnetwork revealed that six miRNAs (miR-124, miR-137, miR-219-5p, miR-34a, miR-9, and miR-92b) might play important roles in GBM, including some results that are supported by previous studies." -other hsa-mir-34a Glioblastoma 22829753 "Our follow up topological and functional analyses of the subnetwork revealed that six miRNAs (miR-124, miR-137, miR-219-5p, miR-34a, miR-9, and miR-92b) might play important roles in GBM, including some results that are supported by previous studies." -other hsa-mir-9 Glioblastoma 22829753 "Our follow up topological and functional analyses of the subnetwork revealed that six miRNAs (miR-124, miR-137, miR-219-5p, miR-34a, miR-9, and miR-92b) might play important roles in GBM, including some results that are supported by previous studies." -other hsa-mir-92b Glioblastoma 22829753 "Our follow up topological and functional analyses of the subnetwork revealed that six miRNAs (miR-124, miR-137, miR-219-5p, miR-34a, miR-9, and miR-92b) might play important roles in GBM, including some results that are supported by previous studies." -other hsa-mir-210 Ischemic Diseases [unspecific] 22833359 miR-210 activates notch signaling pathway in angiogenesis induced by cerebral ischemia. -other hsa-mir-155 Glioblastoma 22834637 A relationship between knock-down of miR-155 and re-expression of GABRA 1 protein in vivo was recently individuated. -other hsa-mir-185 Glioma 22834685 LRRC4 inhibits glioma cell growth and invasion through a miR-185-dependent pathway. -other hsa-mir-210 Preeclampsia 22840297 MIR-210 modulates mitochondrial respiration in placenta with preeclampsia. -other hsa-mir-144 "Leukemia, Myeloid, Chronic" 22842456 Myc induced miR-144/451 contributes to the acquired imatinib resistance in chronic myelogenous leukemia cell K562. -other hsa-mir-451a "Leukemia, Myeloid, Chronic" 22842456 Myc induced miR-144/451 contributes to the acquired imatinib resistance in chronic myelogenous leukemia cell K562. -other hsa-mir-451b "Leukemia, Myeloid, Chronic" 22842456 Myc induced miR-144/451 contributes to the acquired imatinib resistance in chronic myelogenous leukemia cell K562. -other hsa-mir-21 Heart Failure 22842854 "TMZ improved RV function (as indicated by an increase in tricuspid annular plane systolic excursion), and inhibited fibrosis. TMZ also protects RVMCs againts apoptosis and increases miR-21 expression." -other hsa-mir-148b "Lymphoma, Non-Hodgkin" 22843616 MicroRNA-148b enhances the radiosensitivity of non-Hodgkin's Lymphoma cells by promoting radiation-induced apoptosis. -other hsa-mir-126 Colorectal Carcinoma 22848274 Elevated microRNA-126 is associated with high vascular endothelial growth factor receptor 2 expression levels and high microvessel density in colorectal cancer. -other hsa-mir-433 Myeloproliferative Neoplasms 22864358 miR-433 is aberrantly expressed in myeloproliferative neoplasms and suppresses hematopoietic cell growth and differentiation. -other hsa-mir-17 Retinoblastoma 22864477 "Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation." -other hsa-mir-18a Retinoblastoma 22864477 "Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation." -other hsa-mir-19b-1 Retinoblastoma 22864477 "Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation." -other hsa-mir-20a Retinoblastoma 22864477 "Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation." -other hsa-mir-92a-1 Retinoblastoma 22864477 "Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation." -other hsa-mir-21 Lung Neoplasms 22866162 The detection of miR-21 expression yielded 78.80% sensitivity and 100.00% specificity in the diagnosis of lung cancer. -other hsa-mir-200a "Carcinoma, Hepatocellular" 22868917 MicroRNA-200a and -200b Mediated Hepatocellular Carcinoma Cell Migration Through the Epithelial to Mesenchymal Transition Markers. -other hsa-mir-200b "Carcinoma, Hepatocellular" 22868917 MicroRNA-200a and -200b Mediated Hepatocellular Carcinoma Cell Migration Through the Epithelial to Mesenchymal Transition Markers. -other hsa-mir-21 Hypertrophy 22879939 TGFbeta-Stimulated MicroRNA-21 Utilizes PTEN to Orchestrate AKT/mTORC1 Signaling for Mesangial Cell Hypertrophy and Matrix Expansion. -other hsa-mir-124-1 Colorectal Carcinoma 22885837 Downregulation of microRNA-124 is an independent prognostic factor in patients with colorectal cancer. -other hsa-mir-124-2 Colorectal Carcinoma 22885837 Downregulation of microRNA-124 is an independent prognostic factor in patients with colorectal cancer. -other hsa-mir-205 Melanoma 22890556 miR-205 is a tumor suppressor microRNAin malignant melanoma. -other hsa-mir-204 Neuroblastoma 22892391 MicroRNA-204 increases sensitivity of neuroblastoma cells to cisplatin and is associated with a favourable clinical outcome. -other hsa-mir-27b Metabolic Syndrome 22893262 "we thus speculate that Rb1 may act though PPAR¦Ã to downregulate mir-27b gene transcription and mature miR-27b activity, which in turn promotes PPAR¦Ã expression and adipogenesis." -other hsa-mir-141 Ovarian Neoplasms 22897840 "Some genes involved in EMT, such as BMP and activin membrane-bound inhibitor (BAMBI), and mir-141 resulted in association with overall or progression free survival." -other hsa-mir-126 "Carcinoma, Lung, Non-Small-Cell" 22900072 MicroRNA-126 Inhibits Tumor Cell Growth and Its Expression Level Correlates with Poor Survival in Non-Small Cell Lung Cancer Patients. -other hsa-mir-320a Diabetes Mellitus 22900199 miR-320 Regulates Glucose-Induced Gene Expression in Diabetes. -other hsa-mir-20a Breast Neoplasms 22901144 Differential Distribution of miR-20a and miR-20b may Underly Metastatic Heterogeneity of Breast Cancers. -other hsa-mir-153-1 Rectal Neoplasms 22903298 "These signatures consisted of three miRNA transcripts (miR-16, miR-590-5p and miR-153) to predict complete vs. incomplete response and two miRNA transcript (miR-519c-3p and miR-561) to predict good vs. poor response with a median accuracy of 100 %." -other hsa-mir-153-2 Rectal Neoplasms 22903298 "These signatures consisted of three miRNA transcripts (miR-16, miR-590-5p and miR-153) to predict complete vs. incomplete response and two miRNA transcript (miR-519c-3p and miR-561) to predict good vs. poor response with a median accuracy of 100 %." -other hsa-mir-16-1 Rectal Neoplasms 22903298 "These signatures consisted of three miRNA transcripts (miR-16, miR-590-5p and miR-153) to predict complete vs. incomplete response and two miRNA transcript (miR-519c-3p and miR-561) to predict good vs. poor response with a median accuracy of 100 %." -other hsa-mir-16-2 Rectal Neoplasms 22903298 "These signatures consisted of three miRNA transcripts (miR-16, miR-590-5p and miR-153) to predict complete vs. incomplete response and two miRNA transcript (miR-519c-3p and miR-561) to predict good vs. poor response with a median accuracy of 100 %." -other hsa-mir-519c Rectal Neoplasms 22903298 "These signatures consisted of three miRNA transcripts (miR-16, miR-590-5p and miR-153) to predict complete vs. incomplete response and two miRNA transcript (miR-519c-3p and miR-561) to predict good vs. poor response with a median accuracy of 100 %." -other hsa-mir-561 Rectal Neoplasms 22903298 "These signatures consisted of three miRNA transcripts (miR-16, miR-590-5p and miR-153) to predict complete vs. incomplete response and two miRNA transcript (miR-519c-3p and miR-561) to predict good vs. poor response with a median accuracy of 100 %." -other hsa-mir-590 Rectal Neoplasms 22903298 "These signatures consisted of three miRNA transcripts (miR-16, miR-590-5p and miR-153) to predict complete vs. incomplete response and two miRNA transcript (miR-519c-3p and miR-561) to predict good vs. poor response with a median accuracy of 100 %." -other hsa-mir-181 Endometrial Neoplasms 22911744 "Three miRNAs families, miR-181, miR-183 and miR-200, are down-regulated during the decidualization process." -other hsa-mir-183 Endometrial Neoplasms 22911744 "Three miRNAs families, miR-181, miR-183 and miR-200, are down-regulated during the decidualization process." -other hsa-mir-200 Endometrial Neoplasms 22911744 "Three miRNAs families, miR-181, miR-183 and miR-200, are down-regulated during the decidualization process." -other hsa-mir-338 Hepatitis B Virus Infection 22912826 The Effect of miR-338-3p on HBx Deletion-Mutant (HBx-d382) Mediated Liver-Cell Proliferation through CyclinD1 Regulation. -other hsa-mir-124-1 Glioma 22918790 CDA-2 induces cell differentiation through suppressing Twist/SLUG signaling via miR-124 in glioma. -other hsa-mir-124-2 Glioma 22918790 CDA-2 induces cell differentiation through suppressing Twist/SLUG signaling via miR-124 in glioma. -other hsa-mir-15b Cervical Neoplasms 22920753 "These data suggested that down-regulation of NDRG2 could enhance sensitivity of Hela cells to cisplatin through inhibiting Bcl-2 protein expression, which might be mediated by up-regulating miR-15b and miR-16." -other hsa-mir-16 Cervical Neoplasms 22920753 "These data suggested that down-regulation of NDRG2 could enhance sensitivity of Hela cells to cisplatin through inhibiting Bcl-2 protein expression, which might be mediated by up-regulating miR-15b and miR-16." -other hsa-mir-138-1 Glioma 22921398 miR-138 has a critical role in promoting growth and survival of bona fide tumor-initiating cells with self-renewal potential. -other hsa-mir-138-2 Glioma 22921398 miR-138 has a critical role in promoting growth and survival of bona fide tumor-initiating cells with self-renewal potential. -other hsa-mir-141 Melanoma 22927992 "The strongest inhibitors of melanoma cell proliferation, including the miR-15/16, miR-141/200a and miR-96/182 families of miRNAs and miR-203." -other hsa-mir-15a Melanoma 22927992 "The strongest inhibitors of melanoma cell proliferation, including the miR-15/16, miR-141/200a and miR-96/182 families of miRNAs and miR-203." -other hsa-mir-15b Melanoma 22927992 "The strongest inhibitors of melanoma cell proliferation, including the miR-15/16, miR-141/200a and miR-96/182 families of miRNAs and miR-203." -other hsa-mir-16-1 Melanoma 22927992 "The strongest inhibitors of melanoma cell proliferation, including the miR-15/16, miR-141/200a and miR-96/182 families of miRNAs and miR-203." -other hsa-mir-16-2 Melanoma 22927992 "The strongest inhibitors of melanoma cell proliferation, including the miR-15/16, miR-141/200a and miR-96/182 families of miRNAs and miR-203." -other hsa-mir-182 Melanoma 22927992 "The strongest inhibitors of melanoma cell proliferation, including the miR-15/16, miR-141/200a and miR-96/182 families of miRNAs and miR-203." -other hsa-mir-200a Melanoma 22927992 "The strongest inhibitors of melanoma cell proliferation, including the miR-15/16, miR-141/200a and miR-96/182 families of miRNAs and miR-203." -other hsa-mir-203 Melanoma 22927992 "The strongest inhibitors of melanoma cell proliferation, including the miR-15/16, miR-141/200a and miR-96/182 families of miRNAs and miR-203." -other hsa-mir-96 Melanoma 22927992 "The strongest inhibitors of melanoma cell proliferation, including the miR-15/16, miR-141/200a and miR-96/182 families of miRNAs and miR-203." -other hsa-mir-151a Prostate Neoplasms 22928040 Genistein Suppresses Prostate Cancer Growth through Inhibition of Oncogenic MicroRNA-151. -other hsa-mir-151b Prostate Neoplasms 22928040 Genistein Suppresses Prostate Cancer Growth through Inhibition of Oncogenic MicroRNA-151. -other hsa-mir-143 Prostate Neoplasms 22929553 "Several miRNAs such as miR-96, miR-182, and miR-143 demonstrated high influence on their target protein complexes and could explain most of the gene expression changes in our analyzed prostate cancer data set." -other hsa-mir-182 Prostate Neoplasms 22929553 "Several miRNAs such as miR-96, miR-182, and miR-143 demonstrated high influence on their target protein complexes and could explain most of the gene expression changes in our analyzed prostate cancer data set." -other hsa-mir-96 Prostate Neoplasms 22929553 "Several miRNAs such as miR-96, miR-182, and miR-143 demonstrated high influence on their target protein complexes and could explain most of the gene expression changes in our analyzed prostate cancer data set." -other hsa-mir-143 Myelodysplastic Syndromes 22929976 Lenalidomide selectively abrogated progenitor activity in cells depleted of miR-143 and miR-145 supporting a key role for miR-143/145 in the sensitivity to lenalidomide of del(5q) myelodysplastic syndrome patients. -other hsa-mir-145 Myelodysplastic Syndromes 22929976 Lenalidomide selectively abrogated progenitor activity in cells depleted of miR-143 and miR-145 supporting a key role for miR-143/145 in the sensitivity to lenalidomide of del(5q) myelodysplastic syndrome patients. -other hsa-let-7b "Carcinoma, Hepatocellular" 22934260 TLR4 signaling induces the release of microparticles by tumor cells that regulate inflammatory cytokine IL-6 of macrophages via microRNA let-7b. -other hsa-mir-296 Esophageal Neoplasms 22939244 differentially regulated -other hsa-mir-127 "Lymphoma, Burkitt" 22941339 Epstein-Barr nuclear antigen 1 induces expression of the cellular microRNA hsa-miR-127 and impairing B-cell differentiation in EBV-infected memory B cells. -other hsa-mir-125b-1 "Carcinoma, Hepatocellular" 22942733 MicroRNA-125b Functions as a Tumor Suppressor in Hepatocellular Carcinoma Cells. -other hsa-mir-125b-2 "Carcinoma, Hepatocellular" 22942733 MicroRNA-125b Functions as a Tumor Suppressor in Hepatocellular Carcinoma Cells. -other hsa-mir-101-1 Pancreatic Neoplasms 22943841 Restoration of E-cadherin expression in pancreatic ductal adenocarcinoma treated with microRNA-101. -other hsa-mir-101-2 Pancreatic Neoplasms 22943841 Restoration of E-cadherin expression in pancreatic ductal adenocarcinoma treated with microRNA-101. -other hsa-mir-125b-1 Myelodysplastic Syndromes 22944560 Myelodysplastic syndrome with a t(2;11)(p21;q23-24) and translocation breakpoint close to miR-125b-1. -other hsa-mir-143 Prostate Neoplasms 22948942 miR-143 and miR-145 inhibit stem cell characteristics of PC-3 prostate cancer cells. -other hsa-mir-145 Prostate Neoplasms 22948942 miR-143 and miR-145 inhibit stem cell characteristics of PC-3 prostate cancer cells. -other hsa-mir-146a Breast Neoplasms 22949171 MicroRNA-146a suppresses metastatic activity in brain metastasis. -other hsa-mir-15a Infection [unspecific] 22953717 "Moreover, miR-664-5p, miR-451 and miR-15a appear as very promising candidates for microRNAs involved in response to pathogen infection." -other hsa-mir-451 Infection [unspecific] 22953717 "Moreover, miR-664-5p, miR-451 and miR-15a appear as very promising candidates for microRNAs involved in response to pathogen infection." -other hsa-mir-664 Infection [unspecific] 22953717 "Moreover, miR-664-5p, miR-451 and miR-15a appear as very promising candidates for microRNAs involved in response to pathogen infection." -other hsa-mir-138-1 Urinary Bladder Cancer 22954303 Decreasing miR-138 increased the cisplatin sensitivity in half of the cell lines and increasing miR-27a and miR-642 generally increased cisplatin sensitivity. -other hsa-mir-138-2 Urinary Bladder Cancer 22954303 Decreasing miR-138 increased the cisplatin sensitivity in half of the cell lines and increasing miR-27a and miR-642 generally increased cisplatin sensitivity. -other hsa-mir-27a Urinary Bladder Cancer 22954303 Decreasing miR-138 increased the cisplatin sensitivity in half of the cell lines and increasing miR-27a and miR-642 generally increased cisplatin sensitivity. -other hsa-mir-642a Urinary Bladder Cancer 22954303 Decreasing miR-138 increased the cisplatin sensitivity in half of the cell lines and increasing miR-27a and miR-642 generally increased cisplatin sensitivity. -other hsa-mir-642b Urinary Bladder Cancer 22954303 Decreasing miR-138 increased the cisplatin sensitivity in half of the cell lines and increasing miR-27a and miR-642 generally increased cisplatin sensitivity. -other hsa-mir-944 Urinary Bladder Cancer 22954303 "Three miRNAs were associated with both response (to chemotherapy) and survival (886-3p, 923, 944)." -other hsa-mir-23b Atherosclerosis 22955103 "In addition, members of the miR-23-27-24 cluster are increased and specifically miR-23b blocks cell cycle progression, whereas miR-27b was shown to reduce endothelial cell repulsive signals." -other hsa-mir-27b Atherosclerosis 22955103 "In addition, members of the miR-23-27-24 cluster are increased and specifically miR-23b blocks cell cycle progression, whereas miR-27b was shown to reduce endothelial cell repulsive signals." -other hsa-mir-219-2 Inflammation 22957142 "Delayed resolution undermines endogenous resolution programs, altering miR-219-2 expression, increasing pro-inflammatory mediators and compromising SPM production that contribute to failed catabasis and homeostasis." -other hsa-mir-210 Melanoma 22962263 "Our findings show how miR-210 induction links hypoxia to immune escape from CTL-mediated lysis, by providing a mechanistic understanding of how this miRNA mediates immunosuppression in oxygen-deprived regions of tumors where cancer stem-like cells and metastatic cellular behaviors are known to evolve." -other hsa-let-7c "Leukemia, Myeloid, Acute" 22964640 miRNA let-7c promotes granulocytic differentiation in acute myeloid leukemia. -other hsa-mir-122 Hepatitis C Virus Infection 22965312 "these findings indicate that miR-122 and functional lipid metabolism are involved in the tissue tropism of HCV infection. In this review, we would like to focus on the role of miR-122 and lipid metabolism in the cell tropism of HCV." -other hsa-mir-122 Metabolic Syndrome 22965541 "These results suggest that proanthocyanidin treatment increased hepatic cholesterol efflux to produce new HDL particles by repressing miR-33, and it reduced lipogenesis by repressing miR-122." -other hsa-mir-33 Metabolic Syndrome 22965541 "These results suggest that proanthocyanidin treatment increased hepatic cholesterol efflux to produce new HDL particles by repressing miR-33, and it reduced lipogenesis by repressing miR-122." -other hsa-mir-10a Gastric Neoplasms 22969895 miRNA expression profile in primary gastric cancers and paired lymph node metastases indicates that miR-10a plays a role in metastasis from primary gastric cancer to lymph nodes. -other hsa-mir-106a Gastrointestinal Neoplasms 22994734 "Under these experimental conditions, MTg-AMOs demonstrated better suppression of the expression of miR-221, miR-106a, miR-21 in gastric cancer cells than that of single AMOs" -other hsa-mir-21 Gastrointestinal Neoplasms 22994734 "Under these experimental conditions, MTg-AMOs demonstrated better suppression of the expression of miR-221, miR-106a, miR-21 in gastric cancer cells than that of single AMOs" -other hsa-mir-221 Gastrointestinal Neoplasms 22994734 "Under these experimental conditions, MTg-AMOs demonstrated better suppression of the expression of miR-221, miR-106a, miR-21 in gastric cancer cells than that of single AMOs" -other hsa-mir-29c Gastric Neoplasms 23001726 The tumor suppressor microRNA-29c is downregulated and restored by celecoxib in human gastric cancer cells. -other hsa-mir-182 Glioma 23006329 "we found that TGF-¦Â induced miR-182 expression, leading to prolonged NF-¦ÊB activation." -other hsa-mir-1 Neuroblastoma 23022474 "FOXP1 is upregulated as a result of gene fusion or amplification in DLBCL and MALT lymphoma and also repression of miRNAs, such as miR-1, miR-34a and miR-504." -other hsa-mir-34a Neuroblastoma 23022474 "FOXP1 is upregulated as a result of gene fusion or amplification in DLBCL and MALT lymphoma and also repression of miRNAs, such as miR-1, miR-34a and miR-504." -other hsa-mir-504 Neuroblastoma 23022474 "FOXP1 is upregulated as a result of gene fusion or amplification in DLBCL and MALT lymphoma and also repression of miRNAs, such as miR-1, miR-34a and miR-504." -other hsa-mir-29a "Carcinoma, Hepatocellular" 23023935 Our findings demonstrate that the expression of miR-29a is important in the regulation of the SPARC-AKT pathway and HCC growth. -other hsa-mir-146 Lung Neoplasms 23035181 "Other significantly differentiated miR families included carcinogenesis-related miR-146, miR-26, and miR-17 (P (FCS) < 0.05)." -other hsa-mir-17 Lung Neoplasms 23035181 "Other significantly differentiated miR families included carcinogenesis-related miR-146, miR-26, and miR-17 (P (FCS) < 0.05)." -other hsa-mir-26 Lung Neoplasms 23035181 "Other significantly differentiated miR families included carcinogenesis-related miR-146, miR-26, and miR-17 (P (FCS) < 0.05)." -other hsa-mir-34a Lung Neoplasms 23036084 microRNA-34a Sensitizes Lung Cancer Cell Lines to DDP Treatment Independent of p53 Status. -other hsa-mir-155 Colon Neoplasms 23036199 Adrenaline promotes cell proliferation and increases chemoresistance in colon cancer HT29 cells through induction of miR-155 -other hsa-mir-17 "Adenocarcinoma, Lung" 23036707 "Moreover, the expression pattern of miR-17, miR-21, and miR-200a in rBM 3-D culture correlated with the expression of their targets and acinar morphogenesis, a differentiation behavior of lung epithelial cells in rBM 3-D culture" -other hsa-mir-200a "Adenocarcinoma, Lung" 23036707 "Moreover, the expression pattern of miR-17, miR-21, and miR-200a in rBM 3-D culture correlated with the expression of their targets and acinar morphogenesis, a differentiation behavior of lung epithelial cells in rBM 3-D culture" -other hsa-mir-21 "Adenocarcinoma, Lung" 23036707 "Moreover, the expression pattern of miR-17, miR-21, and miR-200a in rBM 3-D culture correlated with the expression of their targets and acinar morphogenesis, a differentiation behavior of lung epithelial cells in rBM 3-D culture" -other hsa-mir-200c Prostate Neoplasms 23041061 Epithelial-to-mesenchymal transition leads to docetaxel resistance in prostate cancer and is mediated by reduced expression of miR-200c and miR-205 -other hsa-mir-205 Prostate Neoplasms 23041061 Epithelial-to-mesenchymal transition leads to docetaxel resistance in prostate cancer and is mediated by reduced expression of miR-200c and miR-205 -other hsa-mir-205 "Adenocarcinoma, Lung" 23043084 "Two microRNA panels yielded high diagnostic accuracy in discriminating SCLC from NSCLC (miR-29a and miR-375; area under the curve [AUC], 0.991 and 0.982 for training and validation data set, respectively) and in differentiating SQ from AC (miR-205 and miR-34a; AUC, 0.977 and 0.982 for training and validation data set, respectively) in FFPE surgical lung specimens." -other hsa-mir-29a "Carcinoma, Lung, Small-Cell" 23043084 "Two microRNA panels yielded high diagnostic accuracy in discriminating SCLC from NSCLC (miR-29a and miR-375; area under the curve [AUC], 0.991 and 0.982 for training and validation data set, respectively) and in differentiating SQ from AC (miR-205 and miR-34a; AUC, 0.977 and 0.982 for training and validation data set, respectively) in FFPE surgical lung specimens." -other hsa-mir-34a "Adenocarcinoma, Lung" 23043084 "Two microRNA panels yielded high diagnostic accuracy in discriminating SCLC from NSCLC (miR-29a and miR-375; area under the curve [AUC], 0.991 and 0.982 for training and validation data set, respectively) and in differentiating SQ from AC (miR-205 and miR-34a; AUC, 0.977 and 0.982 for training and validation data set, respectively) in FFPE surgical lung specimens." -other hsa-mir-375 "Carcinoma, Lung, Small-Cell" 23043084 "Two microRNA panels yielded high diagnostic accuracy in discriminating SCLC from NSCLC (miR-29a and miR-375; area under the curve [AUC], 0.991 and 0.982 for training and validation data set, respectively) and in differentiating SQ from AC (miR-205 and miR-34a; AUC, 0.977 and 0.982 for training and validation data set, respectively) in FFPE surgical lung specimens." -other hsa-mir-34a Heart Diseases [unspecific] 23047694 Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function. -other hsa-mir-155 Waldenstrom Macroglobulinemia 23048077 "Importantly, everolimus targeted Waldenstrom macroglobulinemia cells even in the context of bone marrow milieu, where it affected migration, adhesion, and angiogenesis.Everolimus-dependent anti-Waldenstrom macroglobulinemia activity was partially driven by miRNA-155." -other hsa-mir-196b Glioma 23049982 "We have provided the first evidence that expression of miR-196b was associated with the occurrence of pre-operative seizures in low-grade gliomas,and may predict seizure prognosis in patients without pre-operative seizures" -other hsa-mir-155 "Carcinoma, Renal Cell" 23050614 MicroRNA-155 is a predictive marker for survival in patients with clear cell renal cell carcinoma -other hsa-mir-21 Breast Neoplasms 23052036 Endocrine Disruptors Fludioxonil and Fenhexamid Stimulate miR-21 Expression in Breast Cancer Cells -other hsa-mir-451a Esophageal Neoplasms 23053883 Effect of miR-451 on the Biological Behavior of the Esophageal Carcinoma Cell Line EC9706 -other hsa-mir-498 Neoplasms [unspecific] 23055531 "1,25-Dihydroxyvitamin D3 suppresses telomerase expression and human cancer growth through microRNA-498" -other hsa-mir-122 Hepatitis B Virus Infection 23055569 Inhibition of Alpha Interferon (IFN-alpha)-Induced MicroRNA-122 Negatively Affects the Anti-Hepatitis B Virus Efficiency of IFN-§Ø©ã -other hsa-mir-148a Colorectal Carcinoma 23056401 The clinical significance of MiR-148a as a predictive biomarker in patients with advanced colorectal cancer -other hsa-mir-205 Urinary Bladder Cancer 23056551 miR-205 expression promotes cell proliferation and migration of human cervical cancer cells -other hsa-mir-187 Breast Neoplasms 23060431 miR-187 Is an Independent Prognostic Factor in Breast Cancer and Confers Increased Invasive Potential In Vitro -other hsa-mir-218-1 Neoplasms [unspecific] 23060446 miR-218 Directs a Wnt Signaling Circuit to Promote Differentiation of Osteoblasts and Osteomimicry of Metastatic Cancer Cells -other hsa-mir-218-2 Neoplasms [unspecific] 23060446 miR-218 Directs a Wnt Signaling Circuit to Promote Differentiation of Osteoblasts and Osteomimicry of Metastatic Cancer Cells -other hsa-mir-371a Thyroid Neoplasms 23062364 Activation of the two microRNA clusters C19MC and miR-371-3 does not play prominent role in thyroid cancer -other hsa-mir-133a "Cardiomyopathy, Hypertrophic" 23070543 "Consistent with these structural changes, the expression of molecular markers of cardiac hypertrophy were also increased [Nppb(BNP), Myh7-Myh6(¦ÂMHC-¦ÁMHC) (both P < 0.05) and mir-133a (P < 0.01)]." -other hsa-mir-143 Pancreatic Neoplasms 23070684 miR-143 inhibits the metastasis of pancreatic cancer and an associated signaling pathway -other hsa-mir-146b Colitis 23071818 our data indicates that miRNA-146b and PPAR¦Ã activation may be implicated in the regulation of Th17 responses and colitis in C. difficile-infected mice. -other hsa-mir-200c Ovarian Neoplasms 23074172 Restoration of miR-200c to Ovarian Cancer Reduces Tumor Burden and Increases Sensitivity to Paclitaxel -other hsa-mir-376a-1 Glioblastoma 23093778 Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells -other hsa-mir-376a-2 Glioblastoma 23093778 Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells -other hsa-mir-150 Human Immunodeficiency Virus Infection 23094138 "Here, we observed that the expression levels of the cellular factors Trim5¦Á, CypA, APOBEC3G, SAMHD-1, Trim22, tetherin and TREX-1, and the anti-HIV miRNAs miR-28, miR-150, miR-223 and miR-382 was upregulated by IFN-¦Á and IFN-¦Â in macrophages, which may account for the inhibiting effect on viral replication and the antiviral state of these cells." -other hsa-mir-223 Human Immunodeficiency Virus Infection 23094138 "Here, we observed that the expression levels of the cellular factors Trim5¦Á, CypA, APOBEC3G, SAMHD-1, Trim22, tetherin and TREX-1, and the anti-HIV miRNAs miR-28, miR-150, miR-223 and miR-382 was upregulated by IFN-¦Á and IFN-¦Â in macrophages, which may account for the inhibiting effect on viral replication and the antiviral state of these cells." -other hsa-mir-28 Human Immunodeficiency Virus Infection 23094138 "Here, we observed that the expression levels of the cellular factors Trim5¦Á, CypA, APOBEC3G, SAMHD-1, Trim22, tetherin and TREX-1, and the anti-HIV miRNAs miR-28, miR-150, miR-223 and miR-382 was upregulated by IFN-¦Á and IFN-¦Â in macrophages, which may account for the inhibiting effect on viral replication and the antiviral state of these cells." -other hsa-mir-382 Human Immunodeficiency Virus Infection 23094138 "Here, we observed that the expression levels of the cellular factors Trim5¦Á, CypA, APOBEC3G, SAMHD-1, Trim22, tetherin and TREX-1, and the anti-HIV miRNAs miR-28, miR-150, miR-223 and miR-382 was upregulated by IFN-¦Á and IFN-¦Â in macrophages, which may account for the inhibiting effect on viral replication and the antiviral state of these cells." -other hsa-mir-18a Nasopharyngeal Neoplasms 23097559 miR-18a promotes malignant progression by impairing microRNA biogenesis in nasopharyngeal carcinoma -other hsa-mir-222 Glioblastoma 23099529 Electrochemical detection of miRNA-222 by use of a magnetic bead-based bioassay. -other hsa-mir-21 Glioma 23104517 MiR-21 expression in the tumor cell compartment holds unfavorable prognostic value in gliomas -other hsa-mir-20a Leukemia 23114118 "It is concluded that the miR-20a sponge is constructed successfully, and Jurkat-S stable cell line is established, in which the expression of miR-20a is inhibited stably." -other hsa-mir-17 Pulmonary Hypertension 23114789 "MEX suppressed the hypoxic activation of signal transducer and activator of transcription 3 (STAT3) and the upregulation of the miR-17 superfamily of microRNA clusters, whereas it increased lung levels of miR-204, a key microRNA, the expression of which is decreased in human pulmonary hypertension." -other hsa-mir-7-1 Head And Neck Neoplasms 23115635 Regulation of epidermal growth factor receptor signaling and erlotinib sensitivity in head and neck cancer cells by miR-7 -other hsa-mir-7-2 Head And Neck Neoplasms 23115635 Regulation of epidermal growth factor receptor signaling and erlotinib sensitivity in head and neck cancer cells by miR-7 -other hsa-mir-7-3 Head And Neck Neoplasms 23115635 Regulation of epidermal growth factor receptor signaling and erlotinib sensitivity in head and neck cancer cells by miR-7 -other hsa-mir-122 Hepatitis C Virus Infection 23126531 Alcohol Facilitates HCV RNA Replication Via Up-Regulation of miR-122 Expression and Inhibition of Cyclin G1 in Human Hepatoma Cells -other hsa-mir-143 Colorectal Carcinoma 23128394 Analysis of the combined action of miR-143 and miR-145 on oncogenic pathways in colorectal cancer cells reveals a coordinate program of gene repression -other hsa-mir-145 Colorectal Carcinoma 23128394 Analysis of the combined action of miR-143 and miR-145 on oncogenic pathways in colorectal cancer cells reveals a coordinate program of gene repression -other hsa-mir-125b-1 Gastric Neoplasms 23128435 MicroRNA-125b expression in gastric adenocarcinoma and its effect on the proliferation of gastric cancer cells -other hsa-mir-125b-2 Gastric Neoplasms 23128435 MicroRNA-125b expression in gastric adenocarcinoma and its effect on the proliferation of gastric cancer cells -other hsa-mir-9-1 Human Immunodeficiency Virus Infection 23129528 The microRNA-9/B-lymphocyte-induced maturation protein-1/IL-2 axis is differentially regulated in progressive HIV infection -other hsa-mir-9-2 Human Immunodeficiency Virus Infection 23129528 The microRNA-9/B-lymphocyte-induced maturation protein-1/IL-2 axis is differentially regulated in progressive HIV infection -other hsa-mir-21 Lepromatous Leprosy 23134990 "miR-21 and STAT3 are increased in LL lesions with PEH, given their association with epithelial hyperproliferation; and Cbl-b is diminished in LL lesions with PEH compared to classic LL lesions." -other hsa-mir-101-1 Pancreatic Neoplasms 23139258 "The good, the bad and the ugly: a tale of miR-101, miR-21 and miR-155 in pancreatic intraductal papillary mucinous neoplasms" -other hsa-mir-101-2 Pancreatic Neoplasms 23139258 "The good, the bad and the ugly: a tale of miR-101, miR-21 and miR-155 in pancreatic intraductal papillary mucinous neoplasms" -other hsa-mir-155 Pancreatic Neoplasms 23139258 "The good, the bad and the ugly: a tale of miR-101, miR-21 and miR-155 in pancreatic intraductal papillary mucinous neoplasms" -other hsa-mir-21 Pancreatic Neoplasms 23139258 "The good, the bad and the ugly: a tale of miR-101, miR-21 and miR-155 in pancreatic intraductal papillary mucinous neoplasms" -other hsa-mir-101-1 Systemic Lupus Erythematosus 23139385 "MicroRNA-101, mitogen-activated protein kinases and mitogen-activated protein kinases phosphatase-1 in systemic lupus erythematosus" -other hsa-mir-101-2 Systemic Lupus Erythematosus 23139385 "MicroRNA-101, mitogen-activated protein kinases and mitogen-activated protein kinases phosphatase-1 in systemic lupus erythematosus" -other hsa-mir-34a Pancreatic Neoplasms 23140286 Genistein Inhibits Cell Growth and Induces Apoptosis Through Up-regulation of miR-34a in Pancreatic Cancer Cell -other hsa-mir-29c Nasopharyngeal Neoplasms 23142283 MicroRNA-29c enhances the sensitivities of human nasopharyngeal carcinoma to cisplatin-based chemotherapy and radiotherapy -other hsa-mir-1290 Colon Neoplasms 23142292 Up-regulation of microRNA-1290 impairs cytokinesis and affects the reprogramming of colon cancer cells -other hsa-mir-326 Lung Neoplasms 23142363 miR-326 associates with biochemical markers of bone turnover in lung cancer bone metastasis -other hsa-mir-137 Huntington Disease 23145961 "We also identified several microRNAs (miRNAs) whose aberrant repression is directly mediated by REST, including miR-137, which has not previously been shown to be a direct REST target in mouse." -other hsa-mir-96 "Carcinoma, Hepatocellular" 23151657 Inhibition of miR-96 expression reduces cell proliferation and clonogenicity of HepG2 hepatoma cells -other hsa-mir-181 Porcine Reproductive and Respiratory Syndrome Virus Infection 23152505 "As expected, miR-181 and other potential PRRSV-targeting miRNAs (such as miR-206) are expressed much more abundantly in minimally permissive cells or tissues than in highly permissive cells or tissues." -other hsa-mir-638 Neoplasms [unspecific] 23155245 Expression of human endogenous retrovirus-K coincides with that of micro-RNA-663 and -638 in germ-cell tumor cells -other hsa-mir-663a Neoplasms [unspecific] 23155245 Expression of human endogenous retrovirus-K coincides with that of micro-RNA-663 and -638 in germ-cell tumor cells -other hsa-mir-663b Neoplasms [unspecific] 23155245 Expression of human endogenous retrovirus-K coincides with that of micro-RNA-663 and -638 in germ-cell tumor cells -other hsa-mir-34b Mesothelioma 23155254 MicroRNA miR-34b/c enhances cellular radiosensitivity of malignant pleural mesothelioma cells -other hsa-mir-34c Mesothelioma 23155254 MicroRNA miR-34b/c enhances cellular radiosensitivity of malignant pleural mesothelioma cells -other hsa-mir-211 Pancreatic Neoplasms 23155457 High-throughput microRNA (miRNAs) arrays unravel the prognostic role of MiR-211 in pancreatic cancer -other hsa-mir-199a-1 Melanoma 23162627 Let-7b and microRNA-199a inhibit the proliferation of B16F10 melanoma cells -other hsa-mir-199a-2 Melanoma 23162627 Let-7b and microRNA-199a inhibit the proliferation of B16F10 melanoma cells -other hsa-mir-99a "Carcinoma, Renal Cell" 23173671 MicroRNA-99a induces G1-phase cell cycle arrest and suppresses tumorigenicity in renal cell carcinoma -other hsa-mir-99b "Carcinoma, Renal Cell" 23173671 MicroRNA-99a induces G1-phase cell cycle arrest and suppresses tumorigenicity in renal cell carcinoma -other hsa-mir-210 Neoplasms [unspecific] 23173806 "Considering that the exact function of miR-210 is still not well characterized and understood, more investigations should be performed to promote the success of therapeutic-clinical use of miR-210 in cancer" -other hsa-mir-29c Neoplasms [unspecific] 23175151 MicroRNA profiling of peripheral nerve sheath tumours identifies miR-29c as a tumour suppressor gene involved in tumour progression -other hsa-mir-27a Gastric Neoplasms 23175237 MicroRNA-27a inhibitors alone or in combination with perifosine suppress the growth of gastric cancer cells -other hsa-mir-302a Breast Neoplasms 23184229 MicroRNA-302 Replacement Therapy Sensitizes Breast Cancer Cells to Ionizing Radiation -other hsa-mir-22 Esophageal Neoplasms 23188185 Increased miRNA-22 expression sensitizes esophageal squamous cell carcinoma to irradiation -other hsa-mir-146a Cervical Neoplasms 23189617 "The oncogenic proteins E6, E7 and E5 expressed by HPV directly or indirectly lead to the dysregulation of multiple miRNAs such as miR-34a,miR-218, miR-29a and miR-146a" -other hsa-mir-218 Cervical Neoplasms 23189617 "The oncogenic proteins E6, E7 and E5 expressed by HPV directly or indirectly lead to the dysregulation of multiple miRNAs such as miR-34a,miR-218, miR-29a and miR-146a" -other hsa-mir-29a Cervical Neoplasms 23189617 "The oncogenic proteins E6, E7 and E5 expressed by HPV directly or indirectly lead to the dysregulation of multiple miRNAs such as miR-34a,miR-218, miR-29a and miR-146a" -other hsa-mir-34a Cervical Neoplasms 23189617 "The oncogenic proteins E6, E7 and E5 expressed by HPV directly or indirectly lead to the dysregulation of multiple miRNAs such as miR-34a,miR-218, miR-29a and miR-146a" -other hsa-mir-499 Acute Myocardial Infarction 23192357 "The target miRNA is miRNA-499, a biomarker candidate of AMI with low abundance in biological samples. " -other hsa-mir-7-1 Neuroblastoma 23192662 Overexpression of miR-7-1 Increases Efficacy of Green Tea Polyphenols for Induction of Apoptosis in Human Malignant Neuroblastoma SH-SY5Y and SK-N-DZ Cells -other hsa-mir-7-2 Neuroblastoma 23192662 Overexpression of miR-7-1 Increases Efficacy of Green Tea Polyphenols for Induction of Apoptosis in Human Malignant Neuroblastoma SH-SY5Y and SK-N-DZ Cells -other hsa-mir-133b Gastrointestinal Neoplasms 23196799 Fascin-1 overexpression and miR-133b downregulation in the progression of gastrointestinal stromal tumor -other hsa-mir-146a Neoplasms [unspecific] 23200854 Epistasis between MicroRNAs 155 and 146a during T Cell-Mediated Antitumor Immunity -other hsa-mir-155 Neoplasms [unspecific] 23200854 Epistasis between MicroRNAs 155 and 146a during T Cell-Mediated Antitumor Immunity -other hsa-mir-199a-1 Interstitial Cystitis 23201090 miR-199a-5p Regulates Urothelial Permeability and May Play a Role in Bladder Pain Syndrome -other hsa-mir-199a-2 Interstitial Cystitis 23201090 miR-199a-5p Regulates Urothelial Permeability and May Play a Role in Bladder Pain Syndrome -other hsa-mir-126 Cardiovascular Diseases [unspecific] 23201405 Synergistic induction of miR-126 by hypoxia and HDAC inhibitors in cardiac myocytes -other hsa-mir-21 Glioblastoma 23201752 MicroRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in glioblastoma -other hsa-mir-146a Myocardial Ischemic-Reperfusion Injury 23208587 Increased expression of microRNA-146a decreases myocardial ischaemia/reperfusion injury -other hsa-mir-195 Gastrointestinal Neoplasms 23212612 We demonstrated that miR-195-5p is a novel tumor suppressor miRNA and may contribute to gastric carcinogenesis. -other hsa-mir-21 Breast Neoplasms 23216894 Radiation resistance due to high expression of miR-21 and G2/M checkpoint arrest in breast cancer cells -other hsa-mir-106a Melanoma 23217102 "Levels of miR-199a were positively correlated and miR-106a negatively correlated with CEC pre-therapy. Decreases in miR-126 and miR-199a and increases in miR-16 and miR-106a were observed after interferon-alfa-2b, but not after dacarbazine." -other hsa-mir-126 Melanoma 23217102 "Levels of miR-199a were positively correlated and miR-106a negatively correlated with CEC pre-therapy. Decreases in miR-126 and miR-199a and increases in miR-16 and miR-106a were observed after interferon-alfa-2b, but not after dacarbazine." -other hsa-mir-16 Melanoma 23217102 "Levels of miR-199a were positively correlated and miR-106a negatively correlated with CEC pre-therapy. Decreases in miR-126 and miR-199a and increases in miR-16 and miR-106a were observed after interferon-alfa-2b, but not after dacarbazine." -other hsa-mir-199a Melanoma 23217102 "Levels of miR-199a were positively correlated and miR-106a negatively correlated with CEC pre-therapy. Decreases in miR-126 and miR-199a and increases in miR-16 and miR-106a were observed after interferon-alfa-2b, but not after dacarbazine." -other hsa-mir-122 Hepatitis C Virus Infection 23218444 Can tobacco use promote HCV-induced miR-122 hijacking and hepatocarcinogenesis -other hsa-mir-181a-2 Inflammation 23220232 miR-181a and inflammation: miRNA homeostasis response to inflammatory stimuli in vivo -other hsa-mir-34a Anemia 23222379 "Thus, in FA patients, increased apoptosis occurs in target epithelial cells of severe aGVHD, and this deleterious effect is linked to overexpression of miR-34a but not TP53." -other hsa-mir-21 Inflammatory Bowel Diseases 23224068 PDCD4/miR-21 dysregulation in inflammatory bowel disease-associated carcinogenesis -other hsa-mir-449a Hepatitis C Virus Infection 23226395 Hepatitis C Virus Mediated Changes in miRNA-449a Modulates Inflammatory Biomarker YKL40 through Components of the NOTCH Signaling Pathway -other hsa-mir-7-1 Breast Neoplasms 23227519 "An induction of microRNA, miR-7 through estrogen treatment in breast carcinoma" -other hsa-mir-7-2 Breast Neoplasms 23227519 "An induction of microRNA, miR-7 through estrogen treatment in breast carcinoma" -other hsa-mir-7-3 Breast Neoplasms 23227519 "An induction of microRNA, miR-7 through estrogen treatment in breast carcinoma" -other hsa-mir-1-1 Osteosarcoma 23229283 miRNA expression profile in human osteosarcoma: Role of miR-1 and miR-133b in proliferation and cell cycle control -other hsa-mir-1-2 Osteosarcoma 23229283 miRNA expression profile in human osteosarcoma: Role of miR-1 and miR-133b in proliferation and cell cycle control -other hsa-mir-133b Osteosarcoma 23229283 miRNA expression profile in human osteosarcoma: Role of miR-1 and miR-133b in proliferation and cell cycle control -other hsa-mir-30d Prostate Neoplasms 23231923 Identification of miR-30d as a novel prognostic maker of prostate cancer -other hsa-mir-21 Spinal Cord Injuries 23238710 microRNA-21 Regulates Astrocytic Response Following Spinal Cord Injury -other hsa-mir-27a Breast Neoplasms 23240057 MiR-27 as a Prognostic Marker for Breast Cancer Progression and Patient Survival -other hsa-mir-27b Breast Neoplasms 23240057 MiR-27 as a Prognostic Marker for Breast Cancer Progression and Patient Survival -other hsa-mir-206 Heart Failure 23242657 Recent data indicate that these miRNAs as well as miR-206 change their expression quickly in response to physical activity. -other hsa-mir-190a Neuroblastoma 23245204 MiR-190 leads to aggressive phenotype of neuroblastoma through indirect activation of TrkB pathway -other hsa-mir-190b Neuroblastoma 23245204 MiR-190 leads to aggressive phenotype of neuroblastoma through indirect activation of TrkB pathway -other hsa-mir-122 Hepatitis C Virus Infection 23245472 MicroRNA-122-dependent and -independent replication of Hepatitis C Virus in Hep3B human hepatoma cells -other hsa-mir-25 Neoplasms [unspecific] 23246404 Downregulation of the Mitochondrial Calcium Uniporter by Cancer-Related miR-25 -other hsa-mir-21 Multiple Myeloma 23247593 "Set9, NF-kB, and microRNA-21 mediate berberine-induced apoptosis of human multiple myeloma cells" -other hsa-mir-122 Hepatitis C Virus Infection 23248316 Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication -other hsa-let-7i Respiratory Syncytial Virus Pneumonia 23249809 we found that the RSV nonstructural genes NS1 and NS2 antagonized the upregulation of let-7i and miR-30b -other hsa-mir-30b Respiratory Syncytial Virus Pneumonia 23249809 we found that the RSV nonstructural genes NS1 and NS2 antagonized the upregulation of let-7i and miR-30b -other hsa-mir-196a-1 Breast Neoplasms 23250869 A MicroRNA196a2* and TP63 Circuit Regulated by Estrogen Receptor-alpha and ERK2 that Controls Breast Cancer Proliferation and Invasiveness Properties -other hsa-mir-196a-2 Breast Neoplasms 23250869 A MicroRNA196a2* and TP63 Circuit Regulated by Estrogen Receptor-alpha and ERK2 that Controls Breast Cancer Proliferation and Invasiveness Properties -other hsa-mir-155 Diabetes Mellitus 23250986 Global Remodeling of the Vascular Stem Cell Niche in Bone Marrow of Diabetic Patients: Implication of the miR-155/FOXO3a Signaling Pathway -other hsa-mir-125b-1 Human Immunodeficiency Virus Infection 23251514 Cocaine Enhances HIV-1 Replication in CD4+ T Cells by Down-Regulating MiR-125b -other hsa-mir-125b-2 Human Immunodeficiency Virus Infection 23251514 Cocaine Enhances HIV-1 Replication in CD4+ T Cells by Down-Regulating MiR-125b -other hsa-mir-182 Glioma 23252827 The miR-183/96/182 Cluster Regulates Oxidative Apoptosis and Sensitizes Cells to Chemotherapy in Gliomas -other hsa-mir-183 Glioma 23252827 The miR-183/96/182 Cluster Regulates Oxidative Apoptosis and Sensitizes Cells to Chemotherapy in Gliomas -other hsa-mir-96 Glioma 23252827 The miR-183/96/182 Cluster Regulates Oxidative Apoptosis and Sensitizes Cells to Chemotherapy in Gliomas -other hsa-mir-29b-1 Multiple Myeloma 23254643 miR-29b negatively regulates human osteoclastic cell differentiation and function: Implications for the treatment of multiple myeloma-related bone disease -other hsa-mir-29b-2 Multiple Myeloma 23254643 miR-29b negatively regulates human osteoclastic cell differentiation and function: Implications for the treatment of multiple myeloma-related bone disease -other hsa-mir-27a Ovarian Neoplasms 23254909 "The microRNA-27a: ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2 and survivin expression in ovarian epithelial cancer cells" -other hsa-mir-17 Lung Neoplasms 23263848 miR-17-5p may be potential biomarker for prediction the prognosis in patients with lung cancer. -other hsa-mir-146b Thyroid Neoplasms 23264400 Prognostic Implications of miR-146b Expression and Its Functional Role in Papillary Thyroid Carcinoma -other hsa-mir-21 Prostate Neoplasms 23272133 Resveratrol Reduces Prostate Cancer Growth and Metastasis by Inhibiting the Akt/MicroRNA-21 Pathway -other hsa-mir-194 Breast Neoplasms 23273170 Manipulation of the miR-194 expression level using a synthetic inhibiting RNA produced a small but significant suppression of cell proliferation and upregulation in the expression of several genes that are thought to act as tumor suppressors in MCF-7 and T47D breast cancer cells. -other hsa-mir-30d Neoplasms [unspecific] 23274497 mir-30d Regulates multiple genes in the autophagy pathway and impairs autophagy process in human cancer cells -other hsa-mir-137 Colorectal Carcinoma 23275153 Overexpression of paxillin induced by miR-137 suppression promotes tumor progression and metastasis in colorectal cancer -other hsa-mir-143 Esophageal Neoplasms 23276710 miR-143 may act as a tumor suppressor in ESCC -other hsa-mir-18a Rheumatoid Arthritis 23280137 The TNFa-induced miR-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-§Ø¨mB signaling -other hsa-mir-140 Osteoarthritis 23281373 Detection of the expression level of miR-140 using realtime fluorescent quantitative PCR in knee synovial fluid of osteoarthritis patients -other hsa-mir-7-1 Parkinson Disease 23281385 MiR-7 variation is not associated with PD in Chinese patients -other hsa-mir-7-2 Parkinson Disease 23281385 MiR-7 variation is not associated with PD in Chinese patients -other hsa-mir-7-3 Parkinson Disease 23281385 MiR-7 variation is not associated with PD in Chinese patients -other hsa-let-7e "Carcinoma, Hepatocellular" 23282077 "MiR-16, miR-30a, Let-7e and miR-204 were identified as key miRNA regulators contributed to HCC metastasis." -other hsa-mir-16 "Carcinoma, Hepatocellular" 23282077 "MiR-16, miR-30a, Let-7e and miR-204 were identified as key miRNA regulators contributed to HCC metastasis." -other hsa-mir-204 "Carcinoma, Hepatocellular" 23282077 "MiR-16, miR-30a, Let-7e and miR-204 were identified as key miRNA regulators contributed to HCC metastasis." -other hsa-mir-30a "Carcinoma, Hepatocellular" 23282077 "MiR-16, miR-30a, Let-7e and miR-204 were identified as key miRNA regulators contributed to HCC metastasis." -other hsa-mir-29a Hepatitis B Virus Infection 23285022 MicroRNA-29a-5p Is a Novel Predictor for Early Recurrence of Hepatitis B Virus-Related Hepatocellular Carcinoma after Surgical Resection -other hsa-mir-193b Lymphoma 23288923 "Interestingly, down-regulation of micro-RNAs mmu-miR-30a and mmu-miR-141 as well as hsa-miR-193b clearly contributes to enhance the expression of this gene in mouse and human lymphomas" -other hsa-mir-155 Inflammatory Bowel Diseases 23288924 OVER EXPRESSION OF MICRORNAS-155 AND 21 TARGETING MISMATCH REPAIR PROTEINS IN INFLAMMATORY BOWEL DISEASES -other hsa-mir-21 Inflammatory Bowel Diseases 23288924 OVER EXPRESSION OF MICRORNAS-155 AND 21 TARGETING MISMATCH REPAIR PROTEINS IN INFLAMMATORY BOWEL DISEASES -other hsa-mir-140 Osteoarthritis 23291479 "MiR-146a and -155 were mainly reported for RA, miR-140 was mainly reported for OA including cartilage development." -other hsa-mir-146a Rheumatoid Arthritis 23291479 "MiR-146a and -155 were mainly reported for RA, miR-140 was mainly reported for OA including cartilage development." -other hsa-mir-155 Rheumatoid Arthritis 23291479 "MiR-146a and -155 were mainly reported for RA, miR-140 was mainly reported for OA including cartilage development." -other hsa-mir-34a Neoplasms [unspecific] 23292172 Oncolytic adenovirus co-expressing miRNA-34a and IL-24 induces superior antitumor activity in experimental tumor model -other hsa-mir-146a Psychotic Disorders 23295264 Down-regulation of inflammation-protective microRNAs 146a and 212 in monocytes of patients with postpartum psychosis -other hsa-mir-212 Psychotic Disorders 23295264 Down-regulation of inflammation-protective microRNAs 146a and 212 in monocytes of patients with postpartum psychosis -other hsa-mir-200a Endometrial Neoplasms 23295740 Tamoxifen Represses miR-200 MicroRNAs and Promotes Epithelial-to-Mesenchymal Transition by Up-Regulating c-Myc in Endometrial Carcinoma Cell Lines -other hsa-mir-200b Endometrial Neoplasms 23295740 Tamoxifen Represses miR-200 MicroRNAs and Promotes Epithelial-to-Mesenchymal Transition by Up-Regulating c-Myc in Endometrial Carcinoma Cell Lines -other hsa-mir-200c Endometrial Neoplasms 23295740 Tamoxifen Represses miR-200 MicroRNAs and Promotes Epithelial-to-Mesenchymal Transition by Up-Regulating c-Myc in Endometrial Carcinoma Cell Lines -other hsa-mir-99a Glioblastoma 23298836 The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma -other hsa-mir-23b Prostate Neoplasms 23300597 The microRNA -23b/-27b Cluster Suppresses the Metastatic Phenotype of Castration-Resistant Prostate Cancer Cells -other hsa-mir-27b Prostate Neoplasms 23300597 The microRNA -23b/-27b Cluster Suppresses the Metastatic Phenotype of Castration-Resistant Prostate Cancer Cells -other hsa-mir-138-1 Neoplasms [unspecific] 23300839 MicroRNA-138 Suppresses Neutrophil Gelatinase-Associated Lipocalin Expression and Inhibits Tumorigenicity -other hsa-mir-138-2 Neoplasms [unspecific] 23300839 MicroRNA-138 Suppresses Neutrophil Gelatinase-Associated Lipocalin Expression and Inhibits Tumorigenicity -other hsa-mir-130a Glioblastoma 23302469 Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients -other hsa-mir-155 Glioblastoma 23302469 Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients -other hsa-mir-210 Glioblastoma 23302469 Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients -other hsa-mir-323a Glioblastoma 23302469 Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients -other hsa-mir-323b Glioblastoma 23302469 Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients -other hsa-mir-326 Glioblastoma 23302469 Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients -other hsa-mir-329-1 Glioblastoma 23302469 Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients -other hsa-mir-329-2 Glioblastoma 23302469 Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients -other hsa-mir-155 Breast Neoplasms 23302487 "miR-155, as an oncomir, promotes lymph node involvement and vascular invasion and accompanies over-expressed HER-2 on breast cancer FFPE tissue" -other hsa-mir-210 Heart Failure 23302636 MicroRNA 210 as a Biomarker for Congestive Heart Failure -other hsa-mir-10b Glioblastoma 23307328 Inhibition of miR-10b strongly reduced cell invasion and migration in glioblastoma cell and stem cell lines while overexpression of miR-10b induced cell migration and invasion -other hsa-mir-16-1 Colon Neoplasms 23308284 The Induction of microRNA-16 in Colon Cancer Cells by Protein Arginine Deiminase Inhibition Causes a p53-Dependent Cell Cycle Arrest -other hsa-mir-16-2 Colon Neoplasms 23308284 The Induction of microRNA-16 in Colon Cancer Cells by Protein Arginine Deiminase Inhibition Causes a p53-Dependent Cell Cycle Arrest -other hsa-mir-182 Urinary Bladder Cancer 23313739 MicroRNA-182 plays an onco-miRNA role in cervical cancer -other hsa-mir-34b Neoplasms [unspecific] 23314612 MicroRNA-34b functions as a tumor suppressor and acts as a nodal point in the feedback loop with Met -other hsa-mir-155 "Carcinoma, Hepatocellular" 23316018 These results suggest that S100A4 exerts its effects through the regulation of miR-155 expression in HCC cells -other hsa-mir-30b Vascular Disease [unspecific] 23316327 Bone Morphogenetic Protein-2 Decreases MicroRNA-30b and MicroRNA-30c to Promote Vascular Smooth Muscle Cell Calcification -other hsa-mir-30c-1 Vascular Disease [unspecific] 23316327 Bone Morphogenetic Protein-2 Decreases MicroRNA-30b and MicroRNA-30c to Promote Vascular Smooth Muscle Cell Calcification -other hsa-mir-30c-2 Vascular Disease [unspecific] 23316327 Bone Morphogenetic Protein-2 Decreases MicroRNA-30b and MicroRNA-30c to Promote Vascular Smooth Muscle Cell Calcification -other hsa-mir-200a Breast Neoplasms 23318438 WASF3 regulates miR-200 inactivation by ZEB1 through suppression of KISS1 leading to increased invasiveness in breast cancer cells -other hsa-mir-200b Breast Neoplasms 23318438 WASF3 regulates miR-200 inactivation by ZEB1 through suppression of KISS1 leading to increased invasiveness in breast cancer cells -other hsa-mir-200c Breast Neoplasms 23318438 WASF3 regulates miR-200 inactivation by ZEB1 through suppression of KISS1 leading to increased invasiveness in breast cancer cells -other hsa-mir-143 Prostate Neoplasms 23321517 Mir143 expression inversely correlates with nuclear ERK5 immunoreactivity in clinical prostate cancer -other hsa-mir-374a Breast Neoplasms 23321667 MicroRNA-374a activates Wnt/beta-catenin signaling to promote breast cancer metastasis -other hsa-mir-126 Atherosclerosis 23324496 whereas the endothelial cell-specific miRNA-126 signals the need for endothelial repair through its transfer from apoptotic endothelial cells in microvesicles -other hsa-mir-145 Atherosclerosis 23324496 "Downregulation of miR-145, which controls differentiation of smooth muscle cells, promotes lesion formation" -other hsa-mir-155 Atherosclerosis 23324496 Elevated miR-155 levels are characteristic of proinflammatory macrophages and atherosclerotic lesions -other hsa-mir-125a Colon Neoplasms 23327190 miR-125a/b Regulates the Activation of Cancer Stem Cells in Paclitaxel-resistant Colon Cancer -other hsa-mir-125b-1 Colon Neoplasms 23327190 miR-125a/b Regulates the Activation of Cancer Stem Cells in Paclitaxel-resistant Colon Cancer -other hsa-mir-125b-2 Colon Neoplasms 23327190 miR-125a/b Regulates the Activation of Cancer Stem Cells in Paclitaxel-resistant Colon Cancer -other hsa-mir-34a Choriocarcinoma 23327670 MiR-34a was either inhibited or ectopically expressed transiently in two choriocarcinoma cell lines (BeWo and JEG-3) respectively. -other hsa-mir-708 Breast Neoplasms 23328481 Our findings uncover a mechanistic role for miR-708 in metastasis and provide arationale for developing miR-708 as a therapeutic agent against metastatic breast cancer. -other hsa-mir-135b Gastric Neoplasms 23328512 "Quantitative real-time PCR was used to validate the reliability of microarray and detect miR-135b expression in the above clinical samples, as well as cell lines GES-1, BGC-823 and SGC-7901." -other hsa-let-7a Pancreatic Neoplasms 23335963 These data demonstrate an intricate post-transcriptional regulation of RRM2 and chemosensitivity by let-7a and that the manipulation of regulatory proteins involved in let-7a transcription/processing may provide a mechanism for improving chemotherapeutic and/or tumor growth control responses in pancreatic cancer. -other hsa-mir-199a-1 Breast Neoplasms 23337876 "our data identify miR-199a-5p as a novel and unique regulator of autophagy, which plays an important role in cancer biology and cancer therapy" -other hsa-mir-199a-2 Breast Neoplasms 23337876 "our data identify miR-199a-5p as a novel and unique regulator of autophagy, which plays an important role in cancer biology and cancer therapy" -other hsa-mir-124 Glioma 23338605 "Luciferase reporter assay confirmed that miR-124, miR-128, miR-146b and miR-218 conferred exogenous gene expression with glioma-specificity." -other hsa-mir-128 Glioma 23338605 "Luciferase reporter assay confirmed that miR-124, miR-128, miR-146b and miR-218 conferred exogenous gene expression with glioma-specificity." -other hsa-mir-146b Glioma 23338605 "Luciferase reporter assay confirmed that miR-124, miR-128, miR-146b and miR-218 conferred exogenous gene expression with glioma-specificity." -other hsa-mir-218 Glioma 23338605 "Luciferase reporter assay confirmed that miR-124, miR-128, miR-146b and miR-218 conferred exogenous gene expression with glioma-specificity." -other hsa-mir-23b Breast Neoplasms 23338610 "Pro-oncogenic factors miR-23b- and miR-27b are regulated by Her2/Neu, EGF, and TNFa in breast cancer" -other hsa-mir-146a Influenza 23343627 Host microRNA molecular signatures associated with human H1N1 and H3N2 influenza A viruses reveal an unanticipated antiviral activity for miR-146a -other hsa-let-7a "Carcinoma, Lung, Non-Small-Cell" 23349018 Expression levels of hsa-let-7a (P = 0.005) and miR-16 (P = 0.003) miRNA were significantly higher in squamous cell carcinoma than in adenocarcinoma samples. -other hsa-mir-16 "Carcinoma, Lung, Non-Small-Cell" 23349018 Expression levels of hsa-let-7a (P = 0.005) and miR-16 (P = 0.003) miRNA were significantly higher in squamous cell carcinoma than in adenocarcinoma samples. -other hsa-mir-15a Neoplasms [unspecific] 23353574 "Large-scale screening identifies a novel microRNA, miR-15a-3p, which induces apoptosis in human cancer cell lines" -other hsa-mir-21 Prostate Neoplasms 23353719 "miR-21, miR-221 and miR-222 expression and prostate cancer recurrence among obese and non-obese cases" -other hsa-mir-221 Prostate Neoplasms 23353719 "miR-21, miR-221 and miR-222 expression and prostate cancer recurrence among obese and non-obese cases" -other hsa-mir-222 Prostate Neoplasms 23353719 "miR-21, miR-221 and miR-222 expression and prostate cancer recurrence among obese and non-obese cases" -other hsa-mir-29b-1 Neoplasms [unspecific] 23354167 GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression -other hsa-mir-29b-2 Neoplasms [unspecific] 23354167 GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression -other hsa-mir-199a-1 Neoplasms [unspecific] 23354452 MicroRNA 199b-5p delivery through stable nucleic acid lipid particles (SNALPs) in tumorigenic cell lines -other hsa-mir-199a-2 Neoplasms [unspecific] 23354452 MicroRNA 199b-5p delivery through stable nucleic acid lipid particles (SNALPs) in tumorigenic cell lines -other hsa-mir-199b Neoplasms [unspecific] 23354452 MicroRNA 199b-5p delivery through stable nucleic acid lipid particles (SNALPs) in tumorigenic cell lines -other hsa-mir-92a Immune System Disease [unspecific] 23355465 "we have demonstrated that TLR-mediated miR-92a reduction feedback enhances TLR-triggered production of inflammatory cytokines in macrophages, thus outlining new mechanisms for fine-tuning the TLR-triggered inflammatory response." -other hsa-mir-132 Human Immunodeficiency Virus Infection 23357732 miR-132 enhances HIV-1 replication -other hsa-mir-18b Melanoma 23365201 The Role of miR-18b in MDM2-p53 Pathway Signaling and Melanoma Progression -other hsa-mir-451a Glioblastoma 23367447 "A computational multiscale model of glioblastoma growth: Regulation of cell migration and proliferation via microRNA-451, LKB1 and AMPK" -other hsa-mir-221 Osteosarcoma 23372675 MicroRNA-221 Induces Cell Survival and Cisplatin Resistance through PI3K/Akt Pathway in Human Osteosarcoma -other hsa-mir-376a-1 Retinoblastoma 23373993 Arsenic trioxide induced apoptosis in retinoblastoma cells by abnormal expression of microRNA-376a -other hsa-mir-376a-2 Retinoblastoma 23373993 Arsenic trioxide induced apoptosis in retinoblastoma cells by abnormal expression of microRNA-376a -other hsa-mir-7-1 Glioma 23373996 Regulation of Epidermal Growth Factor Receptor Signaling by plasmid-based MicroRNA-7 inhibits human malignant gliomas growth and metastasis in vivo -other hsa-mir-7-2 Glioma 23373996 Regulation of Epidermal Growth Factor Receptor Signaling by plasmid-based MicroRNA-7 inhibits human malignant gliomas growth and metastasis in vivo -other hsa-mir-7-3 Glioma 23373996 Regulation of Epidermal Growth Factor Receptor Signaling by plasmid-based MicroRNA-7 inhibits human malignant gliomas growth and metastasis in vivo -other hsa-mir-143 Glioblastoma 23376635 miR-143 inhibits glycolysis and depletes stemness of glioblastoma stem-like cells -other hsa-mir-24 Liver Neoplasms 23382622 "This feedback loop, governed by miR-24 and miR-629, promotes a hepatocyte nuclear factor-4¦Á transient inhibition resulting in miR-124 induction and signal transducer and activator of transcription 3 activation." -other hsa-mir-629 Liver Neoplasms 23382622 "This feedback loop, governed by miR-24 and miR-629, promotes a hepatocyte nuclear factor-4¦Á transient inhibition resulting in miR-124 induction and signal transducer and activator of transcription 3 activation." -other hsa-mir-210 Myocardial Infarction 23388440 These data demonstrated that a positive feedback loop involving miR-210 and HIF-1¦Á was important for MSC survival under hypoxic conditions. -other hsa-mir-200b Prostate Neoplasms 23389960 Down-regulation of miR-200b-3p by low p73 contributes to the androgen-independence of prostate cancer cells -other hsa-mir-198 "Carcinoma, Hepatocellular" 23391410 "Control of mitogenic and motogenic pathways by miR-198, diminishing hepatoma cell growth and migration" -other hsa-mir-181a-2 Leukemia 23393335 MicroRNA 181a Influences the Expression of HMGB1 and CD4 in Acute Leukemias -other hsa-mir-200c Ovarian Neoplasms 23394580 a model for the combined regulatory activity of miR-200c and HuR on TUBB3 expression in ovarian cancer -other hsa-mir-126 Breast Neoplasms 23396050 miR-126 and miR-126(*) repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis -other hsa-mir-142 Colorectal Carcinoma 23397547 Downregulation of anti-oncomirs miR-143/145 cluster occurs before APC gene aberration in the development of colorectal tumors -other hsa-mir-145 Colorectal Carcinoma 23397547 Downregulation of anti-oncomirs miR-143/145 cluster occurs before APC gene aberration in the development of colorectal tumors -other hsa-mir-29a Neoplasms [unspecific] 23401122 miR-29a inhibition normalizes HuR over-expression and aberrant AU-rich mRNA stability in invasive cancer -other hsa-mir-124-1 Melanoma 23404119 miR-124a could function as a potent tumor suppressor in the development of uveal melanoma -other hsa-mir-124-2 Melanoma 23404119 miR-124a could function as a potent tumor suppressor in the development of uveal melanoma -other hsa-mir-124-3 Melanoma 23404119 miR-124a could function as a potent tumor suppressor in the development of uveal melanoma -other hsa-mir-145 Prostate Neoplasms 23404342 Wild-type p53 suppresses the epithelial-mesenchymal transition and stemness in PC-3 prostate cancer cells by modulating miR-145 -other hsa-mir-7-1 Glioma 23404538 Poly(amido amine) is an ideal carrier of miR-7 for enhancing gene silencing effects on the EGFR pathway in U251 glioma cells -other hsa-mir-7-2 Glioma 23404538 Poly(amido amine) is an ideal carrier of miR-7 for enhancing gene silencing effects on the EGFR pathway in U251 glioma cells -other hsa-mir-7-3 Glioma 23404538 Poly(amido amine) is an ideal carrier of miR-7 for enhancing gene silencing effects on the EGFR pathway in U251 glioma cells -other hsa-mir-122 Hepatitis C Virus Infection 23405269 microRNA-122 Dependent Binding of Ago2 Protein to Hepatitis C Virus RNA Is Associated with Enhanced RNA Stability and Translation Stimulation -other hsa-mir-342 Breast Neoplasms 23408138 miR-342 is associated with estrogen receptor-§Ø©ãexpression and response to tamoxifen in breast cancer -other hsa-mir-99a Glioblastoma 23409016 Photofrin Based Photodynamic Therapy and miR-99a Transfection Inhibited FGFR3 and PI3K/Akt Signaling Mechanisms to Control Growth of Human Glioblastoma In Vitro and In Vivo -other hsa-mir-133a-1 Urinary Bladder Cancer 23410519 "A Common microRNA Signature Consisting of miR-133a, miR-139-3p, and miR-142-3p Clusters Bladder Carcinoma in Situ With Normal Umbrella Cells" -other hsa-mir-139 Urinary Bladder Cancer 23410519 "A Common microRNA Signature Consisting of miR-133a, miR-139-3p, and miR-142-3p Clusters Bladder Carcinoma in Situ With Normal Umbrella Cells" -other hsa-mir-142 Urinary Bladder Cancer 23410519 "A Common microRNA Signature Consisting of miR-133a, miR-139-3p, and miR-142-3p Clusters Bladder Carcinoma in Situ With Normal Umbrella Cells" -other hsa-mir-106a Glioblastoma 23416698 MiR-106a is an independent prognostic marker in patients with glioblastoma -other hsa-mir-146b Glioma 23419525 Intra-tumor injection of exosomes derived from miR-146-expressing MSCs significantly reduced glioma xenograft growth in a rat model of primary brain tumor. -other hsa-mir-181c Gastric Neoplasms 23425811 miR-181c expression level was significantly related to several clinicopathological features of gastric cancer -other hsa-mir-487b Lung Neoplasms 23426183 Cigarette smoke mediates epigenetic repression of miR-487b during pulmonary carcinogenesis -other hsa-mir-143 Osteosarcoma 23430952 "These effects were associated with decreased expression of Notch-1 and its downstream genes, such as vascular endothelial growth factor and matrix metalloproteinases, as well as increased expression of a panel of tumor-suppressive microRNAs (miRNAs), including miR-34a, miR-143, miR-145 and miR-200b/c that are typically lost in osteosarcoma. " -other hsa-mir-145 Osteosarcoma 23430952 "These effects were associated with decreased expression of Notch-1 and its downstream genes, such as vascular endothelial growth factor and matrix metalloproteinases, as well as increased expression of a panel of tumor-suppressive microRNAs (miRNAs), including miR-34a, miR-143, miR-145 and miR-200b/c that are typically lost in osteosarcoma. " -other hsa-mir-200b Osteosarcoma 23430952 "These effects were associated with decreased expression of Notch-1 and its downstream genes, such as vascular endothelial growth factor and matrix metalloproteinases, as well as increased expression of a panel of tumor-suppressive microRNAs (miRNAs), including miR-34a, miR-143, miR-145 and miR-200b/c that are typically lost in osteosarcoma. " -other hsa-mir-200c Osteosarcoma 23430952 "These effects were associated with decreased expression of Notch-1 and its downstream genes, such as vascular endothelial growth factor and matrix metalloproteinases, as well as increased expression of a panel of tumor-suppressive microRNAs (miRNAs), including miR-34a, miR-143, miR-145 and miR-200b/c that are typically lost in osteosarcoma. " -other hsa-mir-34a Osteosarcoma 23430952 "These effects were associated with decreased expression of Notch-1 and its downstream genes, such as vascular endothelial growth factor and matrix metalloproteinases, as well as increased expression of a panel of tumor-suppressive microRNAs (miRNAs), including miR-34a, miR-143, miR-145 and miR-200b/c that are typically lost in osteosarcoma. " -other hsa-mir-125b-1 Neoplasms [unspecific] 23437196 Forced expression of HER2 and HER3 rescued miR-199a- and miR-125b-inhibiting angiogenesis responses and Akt/p70S6K1/HIF-1§Ø©ãpathway. -other hsa-mir-125b-2 Neoplasms [unspecific] 23437196 Forced expression of HER2 and HER3 rescued miR-199a- and miR-125b-inhibiting angiogenesis responses and Akt/p70S6K1/HIF-1§Ø©ãpathway. -other hsa-mir-199a-1 Neoplasms [unspecific] 23437196 Forced expression of HER2 and HER3 rescued miR-199a- and miR-125b-inhibiting angiogenesis responses and Akt/p70S6K1/HIF-1§Ø©ãpathway. -other hsa-mir-199a-2 Neoplasms [unspecific] 23437196 Forced expression of HER2 and HER3 rescued miR-199a- and miR-125b-inhibiting angiogenesis responses and Akt/p70S6K1/HIF-1§Ø©ãpathway. -other hsa-mir-18a Colorectal Carcinoma 23437304 MicroRNA-18a Attenuates DNA Damage Repair through Suppressing the Expression of Ataxia Telangiectasia Mutated in Colorectal Cancer -other hsa-mir-200a Colorectal Carcinoma 23441132 Down-Regulation of the miRNA-200 Family at the Invasive Front of Colorectal Cancers with Degraded Basement Membrane Indicates EMT Is Involved in Cancer Progression -other hsa-mir-200b Colorectal Carcinoma 23441132 Down-Regulation of the miRNA-200 Family at the Invasive Front of Colorectal Cancers with Degraded Basement Membrane Indicates EMT Is Involved in Cancer Progression -other hsa-mir-200c Colorectal Carcinoma 23441132 Down-Regulation of the miRNA-200 Family at the Invasive Front of Colorectal Cancers with Degraded Basement Membrane Indicates EMT Is Involved in Cancer Progression -other hsa-mir-21 "Carcinoma, Hepatocellular" 23442323 Thyroid hormone regulation of miR-21 enhances migration and invasion of hepatoma -other hsa-mir-218-1 Urinary Bladder Cancer 23443110 MiR-218 Impairs Tumor Growth and Increases Chemo-Sensitivity to Cisplatin in Cervical Cancer -other hsa-mir-218-2 Urinary Bladder Cancer 23443110 MiR-218 Impairs Tumor Growth and Increases Chemo-Sensitivity to Cisplatin in Cervical Cancer -other hsa-mir-138-1 Head And Neck Neoplasms 23445815 Role of microRNA-138 as a Potential Tumor Suppressor in Head and Neck Squamous Cell Carcinoma -other hsa-mir-138-2 Head And Neck Neoplasms 23445815 Role of microRNA-138 as a Potential Tumor Suppressor in Head and Neck Squamous Cell Carcinoma -other hsa-mir-138 Cholangiocarcinoma 23446431 "Downregulation of microRNA-138 enhances the proliferation, migration and invasion of cholangiocarcinoma cells through the upregulation of RhoC/p-ERK/MMP-2/MMP-9." -other hsa-mir-208b Myocardial Infarction 23448306 During surgery miR-208b and miR-499-5p was released in the coronary sinus after cardioplegia-reperfusion to markedly higher levels than in a peripheral vein. -other hsa-mir-499 Myocardial Infarction 23448306 During surgery miR-208b and miR-499-5p was released in the coronary sinus after cardioplegia-reperfusion to markedly higher levels than in a peripheral vein. -other hsa-mir-195 Tongue Neoplasms 23451060 Prognostic Implications of MicoRNA miR-195 Expression in Human Tongue Squamous Cell Carcinoma -other hsa-mir-335 Prostate Neoplasms 23456549 Our data demonstrated for the first time the inhibitory effect of miR-335 on cell proliferation and invasion for PCa cells -other hsa-mir-126 Heart Failure 23465244 Expression of miR-126 and miR-508-5p in endothelial progenitor cells is associated with the prognosis of chronic heart failure patients -other hsa-mir-508 Heart Failure 23465244 Expression of miR-126 and miR-508-5p in endothelial progenitor cells is associated with the prognosis of chronic heart failure patients -other hsa-mir-27a "Carcinoma, Oral" 23472065 Primary Microcephaly Gene MCPH1 Shows Signatures of Tumor Suppressors and Is Regulated by miR-27a in Oral Squamous Cell Carcinoma -other hsa-mir-612 "Carcinoma, Hepatocellular" 23478189 miR-612 suppresses the invasive-metastatic cascade in hepatocellular carcinoma -other hsa-mir-21 Psoriasis 23479230 Mechanistic studies revealed a P2X7R-dependent mir-21 angiogenesis pathway that leads to the expression of vascular endothelial growth factor and IL-6 and that may be involved in the development of psoriatic lesions. -other hsa-mir-221 Multiple Myeloma 23479461 In Vitro and in Vivo Anti-tumor Activity of miR-221/222 Inhibitors in Multiple Myeloma -other hsa-mir-222 Multiple Myeloma 23479461 In Vitro and in Vivo Anti-tumor Activity of miR-221/222 Inhibitors in Multiple Myeloma -other hsa-mir-584 Breast Neoplasms 23479725 Micro-RNA-584 and the protein phosphatase and actin regulator 1 (PHACTR1): New Signaling Route Through Which Transforming Growth Factor-Beta Mediates the Migration and Actin Dynamics of Breast Cancer Cells -other hsa-mir-128-1 Glioblastoma 23482671 "NPV-LDE-225 (Erismodegib) inhibits epithelial mesenchymal transition and self-renewal of glioblastoma initiating cells by regulating miR-21, miR-128, and miR-200" -other hsa-mir-128-2 Glioblastoma 23482671 "NPV-LDE-225 (Erismodegib) inhibits epithelial mesenchymal transition and self-renewal of glioblastoma initiating cells by regulating miR-21, miR-128, and miR-200" -other hsa-mir-200 Glioblastoma 23482671 "NPV-LDE-225 (Erismodegib) inhibits epithelial mesenchymal transition and self-renewal of glioblastoma initiating cells by regulating miR-21, miR-128, and miR-200" -other hsa-mir-21 Glioblastoma 23482671 "NPV-LDE-225 (Erismodegib) inhibits epithelial mesenchymal transition and self-renewal of glioblastoma initiating cells by regulating miR-21, miR-128, and miR-200" -other hsa-mir-101-1 "Carcinoma, Hepatocellular" 23483142 miR-101 inhibits autophagy and enhances cisplatin-induced apoptosis in hepatocellular carcinoma cells -other hsa-mir-101-2 "Carcinoma, Hepatocellular" 23483142 miR-101 inhibits autophagy and enhances cisplatin-induced apoptosis in hepatocellular carcinoma cells -other hsa-mir-132 Epilepsy 23485811 "Functional studies employing antagomirs have identified contributions from miR-34a and miR-132 to seizure-induced neuronal death whereas silencing miR-134 potently reduced status epilepticus, seizure-damage and the later occurrence of spontaneous seizures." -other hsa-mir-34a Epilepsy 23485811 "Functional studies employing antagomirs have identified contributions from miR-34a and miR-132 to seizure-induced neuronal death whereas silencing miR-134 potently reduced status epilepticus, seizure-damage and the later occurrence of spontaneous seizures." -other hsa-mir-210 Lung Neoplasms 23492775 MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines -other hsa-mir-133a Vascular Hypertrophy 23493786 "Our study unraveled for the first time the cardioprotection of choline against cardiac hypertrophy, with correction of expression of miR-133a and calcineurin as a possible mechanism. " -other hsa-mir-17 Feingold Syndrome 23495052 De novo 13q31.1-q32.1 interstitial deletion encompassing the miR-17-92 cluster in a patient with Feingold syndrome-2. -other hsa-mir-18 Feingold Syndrome 23495052 De novo 13q31.1-q32.1 interstitial deletion encompassing the miR-17-92 cluster in a patient with Feingold syndrome-2. -other hsa-mir-19a Feingold Syndrome 23495052 De novo 13q31.1-q32.1 interstitial deletion encompassing the miR-17-92 cluster in a patient with Feingold syndrome-2. -other hsa-mir-19b-1 Feingold Syndrome 23495052 De novo 13q31.1-q32.1 interstitial deletion encompassing the miR-17-92 cluster in a patient with Feingold syndrome-2. -other hsa-mir-20a Feingold Syndrome 23495052 De novo 13q31.1-q32.1 interstitial deletion encompassing the miR-17-92 cluster in a patient with Feingold syndrome-2. -other hsa-mir-92-1 Feingold Syndrome 23495052 De novo 13q31.1-q32.1 interstitial deletion encompassing the miR-17-92 cluster in a patient with Feingold syndrome-2. -other hsa-mir-125b-1 Neoplasms [unspecific] 23497288 miR-125b develops chemoresistance in Ewing sarcoma/primitive neuroectodermal tumor -other hsa-mir-125b-2 Neoplasms [unspecific] 23497288 miR-125b develops chemoresistance in Ewing sarcoma/primitive neuroectodermal tumor -other hsa-mir-133a Arrhythmia 23497314 Multiple miR-133a isomiRs with potential different mRNA target profiles are present in the atrium in humans and mice. -other hsa-mir-155 "Leukemia, Myeloid, Acute" 23497456 Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia -other hsa-mir-92a-1 Ovarian Neoplasms 23499550 miR-92a Inhibits Peritoneal Dissemination of Ovarian Cancer Cells by Inhibiting Integrin Expression. -other hsa-mir-92a-2 Ovarian Neoplasms 23499550 miR-92a Inhibits Peritoneal Dissemination of Ovarian Cancer Cells by Inhibiting Integrin ¦Á5 Expression. -other hsa-mir-100 Prostate Neoplasms 23503652 "Tumor suppressor microRNAs, miR-100 and -125b, are regulated by 1,25-dihydroxyvitamin D in primary prostate cells and in patient tissue." -other hsa-mir-125b Prostate Neoplasms 23503652 "Tumor suppressor microRNAs, miR-100 and -125b, are regulated by 1,25-dihydroxyvitamin D in primary prostate cells and in patient tissue." -other hsa-mir-191 Breast Neoplasms 23505378 Estrogen Mediated-Activation of miR-191/425 Cluster Modulates Tumorigenicity of Breast Cancer Cells Depending on Estrogen Receptor Status -other hsa-mir-425 Breast Neoplasms 23505378 Estrogen Mediated-Activation of miR-191/425 Cluster Modulates Tumorigenicity of Breast Cancer Cells Depending on Estrogen Receptor Status -other hsa-mir-9-1 Human Immunodeficiency Virus Infection 23508624 Modulation of BK Channel by MicroRNA-9 in Neurons After Exposure to HIV and Methamphetamine -other hsa-mir-122 Hepatitis B Virus Infection 23508904 Circulating microRNA-22 correlates with microRNA-122 and represents viral replication and liver injury in patients with chronic hepatitis B -other hsa-mir-22 Hepatitis B Virus Infection 23508904 Circulating microRNA-22 correlates with microRNA-122 and represents viral replication and liver injury in patients with chronic hepatitis B -other hsa-mir-9-1 Leukemia 23509296 a unique role of miR-9 in myelopoiesis and in the pathogenesis of EVI1-induced myeloid neoplasms and provide insights into the epigenetic regulation of miR9 in tumorigenesis -other hsa-mir-9-2 Leukemia 23509296 a unique role of miR-9 in myelopoiesis and in the pathogenesis of EVI1-induced myeloid neoplasms and provide insights into the epigenetic regulation of miR9 in tumorigenesis -other hsa-mir-9-3 Leukemia 23509296 a unique role of miR-9 in myelopoiesis and in the pathogenesis of EVI1-induced myeloid neoplasms and provide insights into the epigenetic regulation of miR9 in tumorigenesis -other hsa-mir-155 Glioblastoma 23512614 "Cytokines (IL-1¦Â and TNF¦Á) also induce the expression of miR-155 and miR-155*, the microRNAs crucial in immunity and inflammation-induced oncogenesis and this is dose-dependently suppressed by IRF3. " -other hsa-mir-155 Atherosclerosis 23513069 The microRNA-342-5p Fosters Inflammatory Macrophage Activation Through an Akt1-and microRNA-155-Dependent Pathway during Atherosclerosis -other hsa-mir-342 Atherosclerosis 23513069 The microRNA-342-5p Fosters Inflammatory Macrophage Activation Through an Akt1-and microRNA-155-Dependent Pathway during Atherosclerosis -other hsa-mir-20a "Leukemia, Myeloid, Acute" 23515710 The clinical characteristics and prognostic significance of MN1 gene and MN1-associated microRNA expression in adult patients with de novo acute myeloid leukemia. -other hsa-mir-17 Rheumatoid Arthritis 23516027 The miR-17???92 Cluster: A Key Player in the Control of Inflammation during Rheumatoid Arthritis. -other hsa-mir-18 Rheumatoid Arthritis 23516027 The miR-17???92 Cluster: A Key Player in the Control of Inflammation during Rheumatoid Arthritis. -other hsa-mir-19a Rheumatoid Arthritis 23516027 The miR-17???92 Cluster: A Key Player in the Control of Inflammation during Rheumatoid Arthritis. -other hsa-mir-19b-1 Rheumatoid Arthritis 23516027 The miR-17???92 Cluster: A Key Player in the Control of Inflammation during Rheumatoid Arthritis. -other hsa-mir-20a Rheumatoid Arthritis 23516027 The miR-17???92 Cluster: A Key Player in the Control of Inflammation during Rheumatoid Arthritis. -other hsa-mir-92-1 Rheumatoid Arthritis 23516027 The miR-17???92 Cluster: A Key Player in the Control of Inflammation during Rheumatoid Arthritis. -other hsa-mir-125a Breast Neoplasms 23519125 "Functional cooperation of miR-125a, miR-125b, and miR-205 in entinostat-induced downregulation of erbB2/erbB3 and apoptosis in breast cancer cells" -other hsa-mir-125b-1 Breast Neoplasms 23519125 "Functional cooperation of miR-125a, miR-125b, and miR-205 in entinostat-induced downregulation of erbB2/erbB3 and apoptosis in breast cancer cells" -other hsa-mir-125b-2 Breast Neoplasms 23519125 "Functional cooperation of miR-125a, miR-125b, and miR-205 in entinostat-induced downregulation of erbB2/erbB3 and apoptosis in breast cancer cells" -other hsa-mir-205 Breast Neoplasms 23519125 "Functional cooperation of miR-125a, miR-125b, and miR-205 in entinostat-induced downregulation of erbB2/erbB3 and apoptosis in breast cancer cells" -other hsa-mir-222 "Leukemia, Acute" 23522449 MicroRNA profiling reveals aberrant microRNA expression in adult ETP-ALL and functional studies implicate a role for miR-222 in acute leukemia -other hsa-mir-26a-1 Pituitary Adenoma 23525216 miR-26a Plays an Important Role in Cell Cycle Regulation in ACTH-Secreting Pituitary Adenomas by Modulating Protein Kinase C -other hsa-mir-26a-2 Pituitary Adenoma 23525216 miR-26a Plays an Important Role in Cell Cycle Regulation in ACTH-Secreting Pituitary Adenomas by Modulating Protein Kinase C -other hsa-mir-34a "Leukemia, Lymphocytic, Chronic, B-Cell" 23525797 Inactivation of TP53 correlates with disease progression and low miR-34a expression in previously treated chronic lymphocytic leukemia patients -other hsa-mir-221 Breast Neoplasms 23529451 miR-221/222: promising biomarkers for breast cancer. -other hsa-mir-222 Breast Neoplasms 23529451 miR-221/222: promising biomarkers for breast cancer. -other hsa-mir-34a Glioma 23529798 These findings indicate the role of miR-34a in tumor progression may be closely associated with p53 mutation and inversely correlated to Bcl-2 expression -other hsa-mir-27a Colorectal Carcinoma 23530649 Resveratrol and Quercetin in Combination Have Anticancer Activity in Colon Cancer Cells and Repress Oncogenic microRNA-27a -other hsa-mir-215 Colorectal Carcinoma 23532818 MicroRNA-215 inhibits relapse of colorectal cancer patients following radical surgery -other hsa-mir-18a Glioma 23533157 Tumorigenic Potential of miR-18A* in Glioma Initiating Cells Requires NOTCH-1 Signaling -other hsa-mir-122 Hepatitis C Virus Infection 23537271 Down-regulating miR-122 expression by HCV core protein may give a new insight into the interaction between HCV and miR-122 and chronic HCV infection -other hsa-mir-155 Hematologic Neoplasms 23538486 Transfection of Kasumi-1 cells with a new type of polymer carriers loaded with miR-155 and antago-miR-155. -other hsa-mir-21 Colon Neoplasms 23544170 Down-regulation of miR-21 Induces Differentiation of Chemoresistant Colon Cancer Cells and Enhances Susceptibility to Therapeutic Regimens -other hsa-mir-200c Breast Neoplasms 23546450 miRNA-200c increases the sensitivity of breast cancer cells to doxorubicin through the suppression of E-cadherin-mediated PTEN/Akt signaling -other hsa-mir-92 "Carcinoma, Hepatocellular" 23546593 Expression and significance of PTEN and miR-92 in hepatocellular carcinoma -other hsa-mir-150 Myocardial Infarction 23547171 MicroRNA-150: A Novel Marker of Left Ventricular Remodeling After Acute Myocardial Infarction -other hsa-mir-21 "Lymphoma, B-Cell" 23548551 Inhibition of miR-21 Induces Biological and Behavioral Alterations in Diffuse Large B-Cell Lymphoma -other hsa-mir-515-1 Breast Neoplasms 23549953 Involvement of IGF-1R regulation by miR-515-5p modifies breast cancer risk among BRCA1 carriers -other hsa-mir-515-2 Breast Neoplasms 23549953 Involvement of IGF-1R regulation by miR-515-5p modifies breast cancer risk among BRCA1 carriers -other hsa-mir-181 Leukemia 23550642 We also present observations based on analyzes of miR-181 family genes that indicate the potential functions of primary and/or precursor miRNAs in target recognition and explore the impact of these findings on target identification. -other hsa-mir-17 Neoplasms [unspecific] 23550645 "Recent functional dissection of mir-17-92 indicates that individual mir-17-92 components perform distinct biological functions, which collectively regulate multiple related cellular processes during development and disease." -other hsa-mir-18 Neoplasms [unspecific] 23550645 "Recent functional dissection of mir-17-92 indicates that individual mir-17-92 components perform distinct biological functions, which collectively regulate multiple related cellular processes during development and disease." -other hsa-mir-19a Neoplasms [unspecific] 23550645 "Recent functional dissection of mir-17-92 indicates that individual mir-17-92 components perform distinct biological functions, which collectively regulate multiple related cellular processes during development and disease." -other hsa-mir-19b-1 Neoplasms [unspecific] 23550645 "Recent functional dissection of mir-17-92 indicates that individual mir-17-92 components perform distinct biological functions, which collectively regulate multiple related cellular processes during development and disease." -other hsa-mir-20a Neoplasms [unspecific] 23550645 "Recent functional dissection of mir-17-92 indicates that individual mir-17-92 components perform distinct biological functions, which collectively regulate multiple related cellular processes during development and disease." -other hsa-mir-92-1 Neoplasms [unspecific] 23550645 "Recent functional dissection of mir-17-92 indicates that individual mir-17-92 components perform distinct biological functions, which collectively regulate multiple related cellular processes during development and disease." -other hsa-mir-15a "Leukemia, B-Cell" 23551855 "DLEU2, which encodes miR-15a and miR-16-1, was discovered from 13q14 deletion in chronic lymphocytic leukemia, while C13orf25, which encodes six mature miRNA (miR-17, miR-18, miR-19a, miR-19b, miR-20a and miR-92a), was identified from 13q31 amplification in aggressive B-cell lymphomas." -other hsa-mir-16-1 "Leukemia, B-Cell" 23551855 "DLEU2, which encodes miR-15a and miR-16-1, was discovered from 13q14 deletion in chronic lymphocytic leukemia, while C13orf25, which encodes six mature miRNA (miR-17, miR-18, miR-19a, miR-19b, miR-20a and miR-92a), was identified from 13q31 amplification in aggressive B-cell lymphomas." -other hsa-mir-17 "Leukemia, B-Cell" 23551855 "DLEU2, which encodes miR-15a and miR-16-1, was discovered from 13q14 deletion in chronic lymphocytic leukemia, while C13orf25, which encodes six mature miRNA (miR-17, miR-18, miR-19a, miR-19b, miR-20a and miR-92a), was identified from 13q31 amplification in aggressive B-cell lymphomas." -other hsa-mir-18 "Leukemia, B-Cell" 23551855 "DLEU2, which encodes miR-15a and miR-16-1, was discovered from 13q14 deletion in chronic lymphocytic leukemia, while C13orf25, which encodes six mature miRNA (miR-17, miR-18, miR-19a, miR-19b, miR-20a and miR-92a), was identified from 13q31 amplification in aggressive B-cell lymphomas." -other hsa-mir-19a "Leukemia, B-Cell" 23551855 "DLEU2, which encodes miR-15a and miR-16-1, was discovered from 13q14 deletion in chronic lymphocytic leukemia, while C13orf25, which encodes six mature miRNA (miR-17, miR-18, miR-19a, miR-19b, miR-20a and miR-92a), was identified from 13q31 amplification in aggressive B-cell lymphomas." -other hsa-mir-19b "Leukemia, B-Cell" 23551855 "DLEU2, which encodes miR-15a and miR-16-1, was discovered from 13q14 deletion in chronic lymphocytic leukemia, while C13orf25, which encodes six mature miRNA (miR-17, miR-18, miR-19a, miR-19b, miR-20a and miR-92a), was identified from 13q31 amplification in aggressive B-cell lymphomas." -other hsa-mir-20a "Leukemia, B-Cell" 23551855 "DLEU2, which encodes miR-15a and miR-16-1, was discovered from 13q14 deletion in chronic lymphocytic leukemia, while C13orf25, which encodes six mature miRNA (miR-17, miR-18, miR-19a, miR-19b, miR-20a and miR-92a), was identified from 13q31 amplification in aggressive B-cell lymphomas." -other hsa-mir-92a "Leukemia, B-Cell" 23551855 "DLEU2, which encodes miR-15a and miR-16-1, was discovered from 13q14 deletion in chronic lymphocytic leukemia, while C13orf25, which encodes six mature miRNA (miR-17, miR-18, miR-19a, miR-19b, miR-20a and miR-92a), was identified from 13q31 amplification in aggressive B-cell lymphomas." -other hsa-mir-31 Ovarian Neoplasms 23552883 Downregulation of miRNA-31 induces taxane resistance in ovarian cancer cells through increase of receptor tyrosine kinase MET -other hsa-mir-101-1 Human Immunodeficiency Virus Infection 23554480 HIV-1 Tat C Modulates Expression of miRNA-101 to Suppress VE-Cadherin in Human Brain Microvascular Endothelial Cells -other hsa-mir-101-2 Human Immunodeficiency Virus Infection 23554480 HIV-1 Tat C Modulates Expression of miRNA-101 to Suppress VE-Cadherin in Human Brain Microvascular Endothelial Cells -other hsa-mir-181b Glioma 23554660 MiR-181b suppresses proliferation of and reduces chemoresistance to temozolomide in U87 glioma stem cells. -other hsa-mir-1228 Gastric Neoplasms 23554909 Restoration of miR-1228* Expression Suppresses Epithelial-Mesenchymal Transition in Gastric Cancer -other hsa-mir-574 Prostate Neoplasms 23554959 Genistein Up-Regulates Tumor Suppressor MicroRNA-574-3p in Prostate Cancer -other hsa-mir-221 Human Immunodeficiency Virus Infection 23555914 HIV Tat Induces Expression of ICAM-1 in HUVECs: Implications for miR-221/-222 in HIV-Associated Cardiomyopathy -other hsa-mir-222 Human Immunodeficiency Virus Infection 23555914 HIV Tat Induces Expression of ICAM-1 in HUVECs: Implications for miR-221/-222 in HIV-Associated Cardiomyopathy -other hsa-mir-146a Lung Neoplasms 23555954 "miR-146a Inhibits Cell Growth, Cell Migration and Induces Apoptosis in Non-Small Cell Lung Cancer Cells" -other hsa-mir-155 Diabetes Mellitus 23560074 Bone Marrow Progenitor Cell Therapy-Mediated Paracrine Regulation of Cardiac miRNA-155 Modulates Fibrotic Response in Diabetic Hearts -other hsa-let-7c "Adenocarcinoma, Lung" 23562878 "Ectopic let-7c expression increased the in vitro and in vivo chemo- or radiosensitivity of DTX-resistant LAD cells through enhanced apoptosis, reversal of epithelial-to-mesenchymal phenotypes, and inhibition of in vivo metastatic potential via inactivation of Akt phosphorylation, whereas a let-7c inhibitor decreased the chemo- or radiosensitivity of parental cells" -other hsa-mir-708 Bladder Neoplasms 23568547 miR-708 promotes the development of bladder carcinoma via direct repression of Caspase-2 -other hsa-mir-26 "Carcinoma, Hepatocellular" 23569435 Development of a miR-26 Companion Diagnostic Test for Adjuvant Interferon-alpha Therapy in Hepatocellular Carcinoma -other hsa-mir-107 Glioma 23572380 MicroRNA-107 Inhibits U87 Glioma Stem Cells Growth and Invasion -other hsa-mir-301a Diabetes Mellitus 23573265 MicroRNA-301a Mediated Regulation of Kv4.2 in Diabetes: Identification of Key Modulators -other hsa-mir-143 Colorectal Carcinoma 23574723 MicroRNA-143 inhibits tumor growth and angiogenesis and sensitizes chemosensitivity to oxaliplatin in colorectal cancers -other hsa-mir-19b-1 Osteosarcoma 23574781 MicroRNA-199b-5p is involved in the Notch signaling pathway in osteosarcoma -other hsa-mir-19b-2 Osteosarcoma 23574781 MicroRNA-199b-5p is involved in the Notch signaling pathway in osteosarcoma -other hsa-mir-345 "Carcinoma, Hepatocellular" 23577194 Hepatitis C Virus Core Protein Down-Regulates p21(Waf1/Cip1) and Inhibits Curcumin-Induced Apoptosis through MicroRNA-345 Targeting in Human Hepatoma Cells -other hsa-mir-221 Hepatitis E Virus Infection 23579640 Identification of miR-221 and -222 as important regulators in genotype IV swine hepatitis E virus ORF3-expressing HEK 293 cells -other hsa-mir-222 Hepatitis E Virus Infection 23579640 Identification of miR-221 and -222 as important regulators in genotype IV swine hepatitis E virus ORF3-expressing HEK 293 cells -other hsa-mir-378 "Leukemia, Myeloid, Acute" 23582927 Overexpression of miR-378 is frequent and may affect treatment outcomes in patients with acute myeloid leukemia. -other hsa-mir-223 Colon Neoplasms 23584479 Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells. -other hsa-let-7a Parkinson Disease 23600457 "Furthermore, the lack of LRRK2 leads to an up-regulation of neuronal differentiation-inducing processes, including the Let-7a pathway." -other hsa-mir-17 "Squamous Cell Carcinoma, Oral" 23602254 MicroRNA-17/20a functions to inhibit cell migration and can be used a prognostic marker in oral squamous cell carcinoma. -other hsa-mir-20a "Squamous Cell Carcinoma, Oral" 23602254 MicroRNA-17/20a functions to inhibit cell migration and can be used a prognostic marker in oral squamous cell carcinoma. -other hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 23608884 Loss of p53 and altered miR15-a/16-1¯ýMCL-1 pathway in CLL: insights from TCL1-Tg:p53(-/-) mouse model and primary human leukemia cells. -other hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 23608884 Loss of p53 and altered miR15-a/16-1¯ýMCL-1 pathway in CLL: insights from TCL1-Tg:p53(-/-) mouse model and primary human leukemia cells. -other hsa-mir-1 "Carcinoma, Lung, Non-Small-Cell" 23617628 "Interplay between heme oxygenase-1 and miR-378 affects non-small cell lung carcinoma growth, vascularization, and metastasis." -other hsa-mir-378 "Carcinoma, Lung, Non-Small-Cell" 23617628 "Interplay between heme oxygenase-1 and miR-378 affects non-small cell lung carcinoma growth, vascularization, and metastasis." -other hsa-mir-208a Cardiomegaly 23623871 MiRNA-208a and miRNA-208b are triggered in thyroid hormone-induced cardiac hypertrophy - role of type 1 Angiotensin II receptor (AT1R) on miRNA-208a/¦Á-MHC modulation. -other hsa-mir-208b Cardiomegaly 23623871 MiRNA-208a and miRNA-208b are triggered in thyroid hormone-induced cardiac hypertrophy - role of type 1 Angiotensin II receptor (AT1R) on miRNA-208a/¦Á-MHC modulation. -other hsa-mir-1 Myocardial Infarction 23625462 MicroRNA-1 enhances the angiogenic differentiation of human cardiomyocyte progenitor cells. -other hsa-mir-302a Testicular Germ Cell Tumor 23625774 "Up-regulation of miR-302a significantly increased the sensitivity of NT2 cells to cisplatin by enhancing cisplatin-induced G2/M phase arrest and the subsequent progression to apoptosis.MiR-302a also increased the killing effects of cisplatin by lowering the apoptotic threshold; the same result was also observed in another TGCT-derived cell line, NCCIT." -other hsa-mir-378 Cardiomegaly 23625957 MiR-378 controls cardiac hypertrophy by combined repression of mitogen-activated protein kinase pathway factors. -other hsa-mir-221 Breast Neoplasms 23637992 miR-221 promotes tumorigenesis in human triple negative breast cancer cells. -other hsa-mir-155 Pancreatic Serous Cystic Neoplasm 23638815 "Upregulation of miR-21, miR-155 and miR-708 was found to occur during IPMN malignant transformation." -other hsa-mir-21 Pancreatic Serous Cystic Neoplasm 23638815 "Upregulation of miR-21, miR-155 and miR-708 was found to occur during IPMN malignant transformation." -other hsa-mir-708 Pancreatic Serous Cystic Neoplasm 23638815 "Upregulation of miR-21, miR-155 and miR-708 was found to occur during IPMN malignant transformation." -other hsa-mir-34a Neuroblastoma 23647235 "using the TANA modified antisense oligonucleotide against miR-34a, intracellular levels of miR-34 can be reduced, and consequently, the expression of its target oncogene V-myc myelocytomatosis viral related oncogene, neuroblastoma derived (MYCN) is enhanced. " -other hsa-mir-15a "Carcinoma, Hepatocellular" 23649629 Hepatitis B viral RNA directly mediates down-regulation of the tumor suppressor microRNA miR-15a/miR-16-1 in hepatocytes. -other hsa-mir-16-1 "Carcinoma, Hepatocellular" 23649629 Hepatitis B viral RNA directly mediates down-regulation of the tumor suppressor microRNA miR-15a/miR-16-1 in hepatocytes. -other hsa-mir-183 Pheochromocytoma 23660872 We demonstrated that miR-183 and/or miR-96 impede NGF-induced differentiation in PC12 cells. -other hsa-mir-96 Pheochromocytoma 23660872 We demonstrated that miR-183 and/or miR-96 impede NGF-induced differentiation in PC12 cells. -other hsa-mir-19a Colon Neoplasms 23666757 MicroRNA-19a targets tissue factor to inhibit colon cancer cells migration and invasion. -other hsa-mir-150 "Carcinoma, Lung, Non-Small-Cell" 23670238 "These findings suggest that miR-150, p53 protein and relevant miRNAs are members of a regulatory network in NSCLC tumorigenesis." -other hsa-mir-186 "Carcinoma, Lung, Non-Small-Cell" 23671127 PTTG1 promotes migration and invasion of human non-small cell lung cancer cells and is modulated by miR-186. -other hsa-mir-449b Colorectal Carcinoma 23674142 These data suggest that miR-449b plays a tumor-suppressive role in colon cancer stem cells -other hsa-mir-103 Pancreatic Neoplasms 23674172 Our study demonstrates that the pathophysiology of HNF1A-MODY is associated with the overexpression of miR-103 and miR-224. -other hsa-mir-224 Pancreatic Neoplasms 23674172 Our study demonstrates that the pathophysiology of HNF1A-MODY is associated with the overexpression of miR-103 and miR-224. -other hsa-mir-200a Cervical Neoplasms 23679328 MiR-93 and miR-200a are associated with metastasis and invasion of cervical carcinoma. -other hsa-mir-93 Cervical Neoplasms 23679328 MiR-93 and miR-200a are associated with metastasis and invasion of cervical carcinoma. -other hsa-let-7d "Carcinoma, Hepatocellular" 23682578 "The MC recurrence-related miRNA included let-7d*, miR-328 and miR18a*, which potentially regulate K-ras gene expression. " -other hsa-mir-18a "Carcinoma, Hepatocellular" 23682578 "The MC recurrence-related miRNA included let-7d*, miR-328 and miR18a*, which potentially regulate K-ras gene expression. " -other hsa-mir-328 "Carcinoma, Hepatocellular" 23682578 "The MC recurrence-related miRNA included let-7d*, miR-328 and miR18a*, which potentially regulate K-ras gene expression. " -other hsa-mir-10a "Carcinoma, Thyroid, Medullary" 23685355 Overexpression of miR-10a and miR-375 and downregulation of YAP1 in medullary thyroid carcinoma. -other hsa-mir-375 "Carcinoma, Thyroid, Medullary" 23685355 Overexpression of miR-10a and miR-375 and downregulation of YAP1 in medullary thyroid carcinoma. -other hsa-mir-16 Lymphoma 23686310 Dysregulation of BMI1 and microRNA-16 collaborate to enhance an anti-apoptotic potential in the side population of refractory mantle cell lymphoma. -other hsa-mir-23a "Adenocarcinoma, Gastric" 23688986 "Suppression of miR-23a with ASO-23a obviously inhibited cell growth, colony formation and invasiveness of MGC803 cells and significantly enhanced the cell apoptosis." -other hsa-mir-1 Vascular Hypertrophy 23691029 "The synergistic effect of miR-21 and miR-1 were functionally validated for their significant influences on myocardial apoptosis, cardiac hypertrophy and fibrosis." -other hsa-mir-21 Vascular Hypertrophy 23691029 "The synergistic effect of miR-21 and miR-1 were functionally validated for their significant influences on myocardial apoptosis, cardiac hypertrophy and fibrosis." -other hsa-mir-124 Stroke 23696548 These data demonstrate that p53-mediated neuronal cell death after stroke can be nontranscriptionally regulated by a novel mechanism involving suppression of endogenous cell death inhibitors by miR-124. -other hsa-mir-375 Ovarian Neoplasms 23696927 Mir-375 enhances ruthenium-derived compound Rawq01 induced cell death in human ovarian cancer. -other hsa-mir-146a Chronic Inflammation 23705069 MicroRNA-146a (miR-146a) is a critical negative regulator of inflammation -other hsa-mir-200a "Carcinoma, Lung, Non-Small-Cell" 23708087 The microRNA-200 family targets multiple non-small cell lung cancer prognostic markers in H1299 cells and BEAS-2B cells. -other hsa-mir-200b "Carcinoma, Lung, Non-Small-Cell" 23708087 The microRNA-200 family targets multiple non-small cell lung cancer prognostic markers in H1299 cells and BEAS-2B cells. -other hsa-mir-197 Hepatitis B Virus Infection 23710316 miR-197 Expression in Peripheral Blood Mononuclear Cells from Hepatitis B Virus-Infected Patients. -other hsa-mir-21 Cardiovascular Diseases [unspecific] 23710745 MicroRNA-21 protects cardiomyocytes from tumor necrosis factor-¦Á induced apoptosis in vitro via modulating PTEN/AKT/FOXO3a pathway -other hsa-mir-1 Vascular Hypertrophy 23711953 the muscle-specific miR-1 and miR-133 are involved in cardiac development and hypertrophy -other hsa-mir-145 Pulmonary Hypertension 23713859 "Other microRNAs, such as miR-145, miR-21 and the miR17/92 cluster, have been associated with the disrupted BMPR2 pathway. " -other hsa-mir-17 Pulmonary Hypertension 23713859 "Other microRNAs, such as miR-145, miR-21 and the miR17/92 cluster, have been associated with the disrupted BMPR2 pathway. " -other hsa-mir-18 Pulmonary Hypertension 23713859 "Other microRNAs, such as miR-145, miR-21 and the miR17/92 cluster, have been associated with the disrupted BMPR2 pathway. " -other hsa-mir-19a Pulmonary Hypertension 23713859 "Other microRNAs, such as miR-145, miR-21 and the miR17/92 cluster, have been associated with the disrupted BMPR2 pathway. " -other hsa-mir-19b-1 Pulmonary Hypertension 23713859 "Other microRNAs, such as miR-145, miR-21 and the miR17/92 cluster, have been associated with the disrupted BMPR2 pathway. " -other hsa-mir-204 Pulmonary Hypertension 23713859 Recent studies demonstrated the role of miR-204 and miR- 206 in pulmonary artery smooth muscle cell (PASMC) proliferation. -other hsa-mir-206 Pulmonary Hypertension 23713859 Recent studies demonstrated the role of miR-204 and miR- 206 in pulmonary artery smooth muscle cell (PASMC) proliferation. -other hsa-mir-20a Pulmonary Hypertension 23713859 "Other microRNAs, such as miR-145, miR-21 and the miR17/92 cluster, have been associated with the disrupted BMPR2 pathway. " -other hsa-mir-21 Pulmonary Hypertension 23713859 "Other microRNAs, such as miR-145, miR-21 and the miR17/92 cluster, have been associated with the disrupted BMPR2 pathway. " -other hsa-mir-92-1 Pulmonary Hypertension 23713859 "Other microRNAs, such as miR-145, miR-21 and the miR17/92 cluster, have been associated with the disrupted BMPR2 pathway. " -other hsa-mir-126 Diabetes Mellitus 23713864 Recent studies identified circulating microRNA-126 as a biomarker for myocardial injury and vascular damage in diabetes. -other hsa-mir-125b-1 "Carcinoma, Lung, Non-Small-Cell" 23718732 MTA1 promotes the invasion and migration of non-small cell lung cancer cells by downregulating miR-125b. -other hsa-mir-125b-2 "Carcinoma, Lung, Non-Small-Cell" 23718732 MTA1 promotes the invasion and migration of non-small cell lung cancer cells by downregulating miR-125b. -other hsa-mir-21 Ischemia-Reperfusion Injury 23719532 MiR-21 expression is down-regulated and cell apoptosis is increased in rat myocardium during early ischemia-reperfusion injury. -other hsa-mir-34c Osteosarcoma 23720736 MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma. -other hsa-mir-34a Bladder Neoplasms 23720881 These findings suggest that the relative low expression of miRNA-34a might be involved in the tumorigenesis of bladder cancer. -other hsa-mir-139 Breast Neoplasms 23722663 "Some novel miRNAs without known association to breast cancer were also found, and the putative functions of their PINs were also elucidated. These include miR-139 and miR-383. " -other hsa-mir-383 Breast Neoplasms 23722663 "Some novel miRNAs without known association to breast cancer were also found, and the putative functions of their PINs were also elucidated. These include miR-139 and miR-383. " -other hsa-let-7f "Diabetes Mellitus, Type 2" 23723366 "let-7f, a microRNA which has been related to endothelial angiogenic function, is found to play key role in TSP-2 increase, but let-7f did not directly interact with TSP-2 mRNA." -other hsa-mir-491 "Carcinoma, Hepatocellular" 23725476 MicroRNA-491 is involved in metastasis of hepatocellular carcinoma by inhibitions of matrix metalloproteinase and epithelial to mesenchymal transition. -other hsa-mir-148a Influenza 23731466 "QRT-PCR assay and ROC curve analyses revealed that miR-31, miR-29a and miR-148a all had significant potential diagnostic value for critically ill patients infected with H1N1 influenza virus" -other hsa-mir-29a Influenza 23731466 "QRT-PCR assay and ROC curve analyses revealed that miR-31, miR-29a and miR-148a all had significant potential diagnostic value for critically ill patients infected with H1N1 influenza virus" -other hsa-mir-31 Influenza 23731466 "QRT-PCR assay and ROC curve analyses revealed that miR-31, miR-29a and miR-148a all had significant potential diagnostic value for critically ill patients infected with H1N1 influenza virus" -other hsa-mir-485 "Carcinoma, Lung, Non-Small-Cell" 23734217 hsa-mir-485 Prostatic Neoplasms Prostatic Neoplasms Cytotoxic treatment of DU-145 cells enhanced the release of PCS-miRNAs with the exception of miR-485-3p which was retained by surviving cells. -other hsa-mir-181a-1 Osteosarcoma 23740615 "MicroRNA 181a improves proliferation and invasion, suppresses apoptosis of osteosarcoma cell." -other hsa-mir-181a-2 Osteosarcoma 23740615 "MicroRNA 181a improves proliferation and invasion, suppresses apoptosis of osteosarcoma cell." -other hsa-mir-224 "Carcinoma, Hepatocellular" 23741247 miR-224 functions as an onco-miRNA in hepatocellular carcinoma cells by activating AKT signaling. -other hsa-mir-199a-1 "Carcinoma, Hepatocellular" 23742776 Propofol inhibits the adhesion of hepatocellular carcinoma cells by upregulating microRNA-199a and downregulating MMP-9 expression. -other hsa-mir-199a-2 "Carcinoma, Hepatocellular" 23742776 Propofol inhibits the adhesion of hepatocellular carcinoma cells by upregulating microRNA-199a and downregulating MMP-9 expression. -other hsa-mir-200a Endometrial Neoplasms 23743934 ZEB1 overexpression associated with E-cadherin and microRNA-200 downregulation is characteristic of undifferentiated endometrial carcinoma. -other hsa-mir-200b Endometrial Neoplasms 23743934 ZEB1 overexpression associated with E-cadherin and microRNA-200 downregulation is characteristic of undifferentiated endometrial carcinoma. -other hsa-mir-200c Endometrial Neoplasms 23743934 ZEB1 overexpression associated with E-cadherin and microRNA-200 downregulation is characteristic of undifferentiated endometrial carcinoma. -other hsa-mir-29c Glioma 23744344 Tumor-suppressive effects of miR-29c on gliomas. -other hsa-mir-129-1 Colorectal Carcinoma 23744359 miR-129 promotes apoptosis and enhances chemosensitivity to 5-fluorouracil in colorectal cancer. -other hsa-mir-129-2 Colorectal Carcinoma 23744359 miR-129 promotes apoptosis and enhances chemosensitivity to 5-fluorouracil in colorectal cancer. -other hsa-let-7f-1 Stroke 23745809 "antagomirs to miR-145, -497, -181a, -1 and let-7f have been found to be neuroprotective in vivo." -other hsa-let-7f-2 Stroke 23745809 "antagomirs to miR-145, -497, -181a, -1 and let-7f have been found to be neuroprotective in vivo." -other hsa-mir-1-1 Stroke 23745809 "antagomirs to miR-145, -497, -181a, -1 and let-7f have been found to be neuroprotective in vivo." -other hsa-mir-1-2 Stroke 23745809 "antagomirs to miR-145, -497, -181a, -1 and let-7f have been found to be neuroprotective in vivo." -other hsa-mir-145 Stroke 23745809 "antagomirs to miR-145, -497, -181a, -1 and let-7f have been found to be neuroprotective in vivo." -other hsa-mir-181a-1 Stroke 23745809 "antagomirs to miR-145, -497, -181a, -1 and let-7f have been found to be neuroprotective in vivo." -other hsa-mir-181a-2 Stroke 23745809 "antagomirs to miR-145, -497, -181a, -1 and let-7f have been found to be neuroprotective in vivo." -other hsa-mir-497 Stroke 23745809 "antagomirs to miR-145, -497, -181a, -1 and let-7f have been found to be neuroprotective in vivo." -other hsa-mir-96 Pancreatic Neoplasms 23752186 EVI1 oncogene promotes KRAS pathway through suppression of microRNA-96 in pancreatic carcinogenesis. -other hsa-mir-140 Breast Neoplasms 23752191 Downregulation of miR-140 promotes cancer stem cell formation in basal-like early stage breast cancer. -other hsa-mir-21 Pancreatic Neoplasms 23752880 Endoscopically Acquired Pancreatic Cyst Fluid MicroRNA 21 and 221 Are Associated With Invasive Cancer. -other hsa-mir-221 Pancreatic Neoplasms 23752880 Endoscopically Acquired Pancreatic Cyst Fluid MicroRNA 21 and 221 Are Associated With Invasive Cancer. -other hsa-mir-708 Glioblastoma 23754151 miR-708 acts as a tumor suppressor in human glioblastoma cells. -other hsa-mir-200c "Carcinoma, Renal Cell" 23754305 microRNA-200c modulates the epithelial-to-mesenchymal transition in human renal cell carcinoma metastasis. -other hsa-mir-124-1 Cerebral Ischemia 23754622 MicroRNA-124 protects against focal cerebral ischemia via mechanisms involving Usp14-dependent REST degradation. -other hsa-mir-124-2 Cerebral Ischemia 23754622 MicroRNA-124 protects against focal cerebral ischemia via mechanisms involving Usp14-dependent REST degradation. -other hsa-mir-146a Sepsis 23756365 Morphine induced exacerbation of sepsis is mediated by tempering endotoxin tolerance through modulation of miR-146a. -other hsa-mir-193a Colorectal Carcinoma 23758639 "Potentiality of a triple microRNA classifier: miR-193a-3p, miR-23a and miR-338-5p for early detection of colorectal cancer." -other hsa-mir-23a Colorectal Carcinoma 23758639 "Potentiality of a triple microRNA classifier: miR-193a-3p, miR-23a and miR-338-5p for early detection of colorectal cancer." -other hsa-mir-338 Colorectal Carcinoma 23758639 "Potentiality of a triple microRNA classifier: miR-193a-3p, miR-23a and miR-338-5p for early detection of colorectal cancer." -other hsa-mir-181a-2 Breast Neoplasms 23759567 MicroRNA-181a/b: Novel biomarkers to stratify breast cancer patients for PARPi treatment. -other hsa-mir-181b-1 Breast Neoplasms 23759567 MicroRNA-181a/b: Novel biomarkers to stratify breast cancer patients for PARPi treatment. -other hsa-mir-181b-2 Breast Neoplasms 23759567 MicroRNA-181a/b: Novel biomarkers to stratify breast cancer patients for PARPi treatment. -other hsa-mir-125b-1 Multiple Myeloma 23759586 Attenuation of dexamethasone-induced cell death in multiple myeloma is mediated by miR-125b expression. -other hsa-mir-125b-2 Multiple Myeloma 23759586 Attenuation of dexamethasone-induced cell death in multiple myeloma is mediated by miR-125b expression. -other hsa-mir-17 Polycystic Kidney Disease 23759744 miR-17-92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease. -other hsa-mir-18a Polycystic Kidney Disease 23759744 miR-17-92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease. -other hsa-mir-19a Polycystic Kidney Disease 23759744 miR-17-92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease. -other hsa-mir-19b-1 Polycystic Kidney Disease 23759744 miR-17-92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease. -other hsa-mir-20a Polycystic Kidney Disease 23759744 miR-17-92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease. -other hsa-mir-92a-1 Polycystic Kidney Disease 23759744 miR-17-92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease. -other hsa-mir-200a "Carcinoma, Hepatocellular" 23760980 MicroRNA-200a/b influenced the therapeutic effects of curcumin in hepatocellular carcinoma (HCC) cells. -other hsa-mir-200b "Carcinoma, Hepatocellular" 23760980 MicroRNA-200a/b influenced the therapeutic effects of curcumin in hepatocellular carcinoma (HCC) cells. -other hsa-mir-99a "Diabetes Mellitus, Type 2" 23762265 Insulin Promotes Glucose Consumption via Regulation of miR-99a/mTOR/PKM2 Pathway. -other hsa-mir-155 "Leukemia-Lymphoma, Adult T-Cell" 23762762 Cellular MicroRNA miR-155 has Important Roles in Leukemogenesis by Human T-Cell Leukemia Virus Type 1 Infection. -other hsa-mir-18b Nasopharyngeal Neoplasms 23764853 Loss of connective tissue growth factor as an unfavorable prognosis factor activates miR-18b by PI3K/AKT/C-Jun and C-Myc and promotes cell growth in nasopharyngeal carcinoma. -other hsa-mir-221 Colorectal Carcinoma 23770133 "In metastatic CRC cells, reduced levels of mir-221* and mir-224 increase levels of MBD2, thereby decreasing expression of the metastasis suppressor maspin. Increased activities of mir-221* and mir-224 reduce growth and metastasis of CRC xenograft tumors in mice; these mirs might be developed as therapeutic reagents or biomarkers of CRC progression." -other hsa-mir-224 Colorectal Carcinoma 23770133 "In metastatic CRC cells, reduced levels of mir-221* and mir-224 increase levels of MBD2, thereby decreasing expression of the metastasis suppressor maspin. Increased activities of mir-221* and mir-224 reduce growth and metastasis of CRC xenograft tumors in mice; these mirs might be developed as therapeutic reagents or biomarkers of CRC progression." -other hsa-mir-768 Melanoma 23770856 Repression of microRNA-768-3p by MEK/ERK signalling contributes to enhanced mRNA translation in human melanoma. -other hsa-mir-122 Hepatitis C Virus Infection 23770926 mir-122 and the Hepatitis C RNA genome: more than just stability. -other hsa-mir-223 Neoplasms [unspecific] 23772809 "mir-223: infection, inflammation and cancer." -other hsa-mir-126 Atherosclerosis 23774505 MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease. -other hsa-mir-133 Atherosclerosis 23774505 MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease. -other hsa-mir-146 Atherosclerosis 23774505 MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease. -other hsa-mir-155 Atherosclerosis 23774505 MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease. -other hsa-mir-21 Atherosclerosis 23774505 MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease. -other hsa-mir-29 Atherosclerosis 23774505 MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease. -other hsa-let-7 Breast Neoplasms 23774803 MicroRNA-profiling in breast- and salivary gland-derived adenoid cystic carcinomas -other hsa-let-7 Salivary Gland Neoplasms 23774803 MicroRNA-profiling in breast- and salivary gland-derived adenoid cystic carcinomas -other hsa-mir-181a-2 Breast Neoplasms 23774803 MicroRNA-profiling in breast- and salivary gland-derived adenoid cystic carcinomas -other hsa-mir-181a-2 Salivary Gland Neoplasms 23774803 MicroRNA-profiling in breast- and salivary gland-derived adenoid cystic carcinomas -other hsa-mir-24 Breast Neoplasms 23774803 MicroRNA-profiling in breast- and salivary gland-derived adenoid cystic carcinomas -other hsa-mir-24 Salivary Gland Neoplasms 23774803 MicroRNA-profiling in breast- and salivary gland-derived adenoid cystic carcinomas -other hsa-mir-155 Pancreatic Neoplasms 23776656 "It is possible that mirNA participates in the pathophysiology of pancreatic cancer, but the current popular methods do not accurately reveal the real-time mirNA function. Thus, this report provided a convenient, accurate, and sensitive approach to mirNA research." -other hsa-mir-200b Pancreatic Neoplasms 23776656 "It is possible that mirNA participates in the pathophysiology of pancreatic cancer, but the current popular methods do not accurately reveal the real-time mirNA function. Thus, this report provided a convenient, accurate, and sensitive approach to mirNA research." -other hsa-mir-132 Encephalomyelitis 23780851 MicroRNA-132 suppresses autoimmune encephalomyelitis by inducing cholinergic anti-inflammation: a new Ahr-based exploration. -other hsa-mir-144 Thyroid Neoplasms 23783103 Almost all microRNAs exhibit isoforms of variable length and potentially distinct function in thyroid tumorigenesis. -other hsa-mir-146b Thyroid Neoplasms 23783103 Almost all microRNAs exhibit isoforms of variable length and potentially distinct function in thyroid tumorigenesis. -other hsa-mir-221 Thyroid Neoplasms 23783103 Almost all microRNAs exhibit isoforms of variable length and potentially distinct function in thyroid tumorigenesis. -other hsa-mir-486 Thyroid Neoplasms 23783103 Almost all microRNAs exhibit isoforms of variable length and potentially distinct function in thyroid tumorigenesis. -other hsa-mir-551b Thyroid Neoplasms 23783103 Almost all microRNAs exhibit isoforms of variable length and potentially distinct function in thyroid tumorigenesis. -other hsa-mir-7 Thyroid Neoplasms 23783103 Almost all microRNAs exhibit isoforms of variable length and potentially distinct function in thyroid tumorigenesis. -other hsa-mir-21 Neoplasms [unspecific] 23784029 MiR-21/Smad 7 signaling determines TGF-¦Â1-induced CAF formation. -other hsa-mir-22 Gastric Neoplasms 23786758 Reduced expression of miR-22 in gastric cancer is related to clinicopathologic characteristics or patient prognosis.. -other hsa-mir-30a "Carcinoma, Ovarian, Serous" 23787480 miRNA expression pattern associated with prognosis in elderly patients with advanced OPSC and OCC. -other hsa-mir-30e "Carcinoma, Ovarian, Serous" 23787480 miRNA expression pattern associated with prognosis in elderly patients with advanced OPSC and OCC. -other hsa-mir-505 "Carcinoma, Ovarian, Serous" 23787480 miRNA expression pattern associated with prognosis in elderly patients with advanced OPSC and OCC. -other hsa-mir-21 Colorectal Carcinoma 23788041 Pleiotropic actions of miR-21 highlight the critical role of deregulated stromal microRNAs during colorectal cancer progression. -other hsa-mir-217 "Carcinoma, Renal Cell, Clear-Cell" 23790169 miR-217 plays a tumor suppressor role in ccRCC. -other hsa-mir-122 "Carcinoma, Breast" 23791885 MicroRNA 'signature' during estrogen-mediated mammary carcinogenesis and its reversal by ellagic acid intervention. -other hsa-mir-127 "Carcinoma, Breast" 23791885 MicroRNA 'signature' during estrogen-mediated mammary carcinogenesis and its reversal by ellagic acid intervention. -other hsa-mir-182 "Carcinoma, Breast" 23791885 MicroRNA 'signature' during estrogen-mediated mammary carcinogenesis and its reversal by ellagic acid intervention. -other hsa-mir-183 "Carcinoma, Breast" 23791885 MicroRNA 'signature' during estrogen-mediated mammary carcinogenesis and its reversal by ellagic acid intervention. -other hsa-mir-206 "Carcinoma, Breast" 23791885 MicroRNA 'signature' during estrogen-mediated mammary carcinogenesis and its reversal by ellagic acid intervention. -other hsa-mir-375 "Carcinoma, Breast" 23791885 MicroRNA 'signature' during estrogen-mediated mammary carcinogenesis and its reversal by ellagic acid intervention. -other hsa-mir-122 Hepatitis C Virus Infection 23793894 A miRNA-responsive cell-free translation system facilitates isolation of hepatitis C virus miRNP complexes. -other hsa-mir-7 "Carcinoma, Renal Cell" 23793934 Identification of miR-7 as an oncogene in renal cell carcinoma. -other hsa-mir-146a Neoplasms [unspecific] 23796062 "Our results indicated that ectopic expression of miR-146a could not independently induce differentiation in lymphoblastic cells. However, the expression of multiple genes involved in T-cell differentiation and T-cell CD markers were found to be affected. These results have suggested a potential tumor suppressive, immunomodulatory and cell activator role for miR146-a." -other hsa-mir-125b Neoplasms [unspecific] 23800395 The expression and regulation of microRNA-125b in cancers. -other hsa-mir-153 Breast Neoplasms 23803066 miR-153 silencing induces apoptosis in the MDA-MB-231 breast cancer cell line. -other hsa-mir-17 Lesch-Nyhan Syndrome 23804752 Deficiency of the purine metabolic gene HPRT dysregulates microRNA-17 family cluster and guanine-based cellular functions: a role for EPAC in Lesch-Nyhan syndrome. -other hsa-mir-335 Neuroblastoma 23806264 "We report, for the first time, that GRP-R-mediated tumorigenicity and increased metastatic potential in neuroblastoma are regulated, in part, by miR-335 and miR-363. A better understanding of the anti-tumor functions of miRNAs could provide valuable insights to discerning molecular mechanisms responsible for neuroblastoma metastasis." -other hsa-mir-363 Neuroblastoma 23806264 "We report, for the first time, that GRP-R-mediated tumorigenicity and increased metastatic potential in neuroblastoma are regulated, in part, by miR-335 and miR-363. A better understanding of the anti-tumor functions of miRNAs could provide valuable insights to discerning molecular mechanisms responsible for neuroblastoma metastasis." -other hsa-mir-200c Neoplasms [unspecific] 23806972 Targeted delivery of miR-200c/DOC to inhibit cancer stem cells and cancer cells by the gelatinases-stimuli nanoparticles. -other hsa-mir-122 Chronic Hepatitis C 23808991 Serum microRNA-122 kinetics in patients with chronic hepatitis C virus infection during antiviral therapy. -other hsa-mir-181b Glioma 23810250 Involvement of FOS-mediated miR-181b/miR-21 signalling in the progression of malignant gliomas. -other hsa-mir-21 Glioma 23810250 Involvement of FOS-mediated miR-181b/miR-21 signalling in the progression of malignant gliomas. -other hsa-mir-196a Huntington Disease 23810380 "miR-196a ameliorates phenotypes of Huntington disease in cell, transgenic mouse, and induced pluripotent stem cell models." -other hsa-mir-126 Coxsackievirus Infection 23811937 MiR-126 promotes coxsackievirus replication by mediating cross-talk of ERK1/2 and Wnt/¦Â-catenin signal pathways. -other hsa-mir-21 Neoplasms [unspecific] 23811941 "AC1MMYR2, an inhibitor of dicer-mediated biogenesis of Oncomir miR-21, reverses epithelial-mesenchymal transition and suppresses tumor growth and progression." -other hsa-mir-203 Glioma 23813496 "Our data validate an important clinical significance of miR-203 in gliomas, and reveal that it might be an intrinsic regulator of tumor progression and a potential prognostic factor for this dismal disease." -other hsa-mir-145 Glioblastoma 23814265 "Our study demonstrates that miR-145 has a tumor-suppressive function in glioblastoma in that it reduces proliferation, adhesion, and invasion of glioblastoma cells, apparently by suppressing the activity of oncogenic proteins Sox9 and ADD3. Reduced levels of miR-145 may lead to neoplastic transformation and malignant progression in glioma due to unregulated activity of these proteins." -other hsa-mir-223 "Leukemia, Lymphoblastic" 23815897 Expression of microRNA-223 in lymphocytic leukemia cells and its action mechanism -other hsa-mir-155 Lymphoma 23815945 Influence of miRNA-155 on lymphoma. -other hsa-mir-155 Hematologic Neoplasms 23815946 Relationship between microRNA-155 and hematological malignancies -other hsa-mir-381 Kidney Neoplasms 23816136 miR-381 increases sensitivity of 786-O cells to 5-FU by inhibitory WEE1 and increase of Cdc2 activity. -other hsa-mir-155 "Carcinoma, Lung, Non-Small-Cell" 23817461 This meta-analysis provides evidence that miR-21 and miR-155 are predicting factors for non-small-cell lung cancer prognosis and lymphoid infiltration. -other hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 23817461 This meta-analysis provides evidence that miR-21 and miR-155 are predicting factors for non-small-cell lung cancer prognosis and lymphoid infiltration. -other hsa-mir-30a Hypertension 23817492 miR-30a regulates endothelial tip cell formation and arteriolar branching. -other hsa-mir-155 Pancreatic Neoplasms 23817566 Regulation of miR-155 affects pancreatic cancer cell invasiveness and migration by modulating the STAT3 signaling pathway through SOCS1. -other hsa-mir-20a "Carcinoma, Cervical" 23819812 Our results suggested that the circulating miR-20a may be a potential biomarker for detecting the lymph node status of cervical cancer patients. -other hsa-mir-302c Neoplasms [unspecific] 23820258 "1,25(OH)2D3 facilitates the immuno-attack of NK cells against malignant cells partly through downregulation of miR-302c and miR-520c and hence upregulation of the NKG2D ligands MICA/B and ULBP2." -other hsa-mir-520c Neoplasms [unspecific] 23820258 "1,25(OH)2D3 facilitates the immuno-attack of NK cells against malignant cells partly through downregulation of miR-302c and miR-520c and hence upregulation of the NKG2D ligands MICA/B and ULBP2." -other hsa-let-7g "Carcinoma, Lung, Non-Small-Cell" 23820752 Let-7g and miR-21 expression in non-small cell lung cancer: correlation with clinicopathological and molecular features -other hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 23820752 Let-7g and miR-21 expression in non-small cell lung cancer: correlation with clinicopathological and molecular features -other hsa-mir-155 "Leukemia, Lymphocytic, Chronic, B-Cell" 23821659 Prognostic value of miR-155 in individuals with monoclonal B-cell lymphocytosis and patients with B chronic lymphocytic leukemia. -other hsa-mir-200c Lung Neoplasms 23824089 NF-¦ÊB-mediated inflammation leading to EMT via miR-200c is involved in cell transformation induced by cigarette smoke extract. -other hsa-mir-29a Salmonellosis 23826261 "Our study outlines for the first time important regulation pathways in intestinal Salmonella infection pointing out that focal adhesion and organisation of actin cytoskeleton are regulated by microRNAs. Functional relevance is shown by miR-29a mediated Caveolin 2 regulation, modulating the activation state of CDC42. Further analysis of examined interactions may support the discovery of novel strategies impairing the uptake of intracellular pathogens." -other hsa-mir-122 Hepatitis C Virus Infection 23826300 Modulation of hepatitis C virus RNA accumulation and translation by DDX6 and miR-122 are mediated by separate mechanisms. -other hsa-mir-25 "Squamous Cell Carcinoma, Tongue" 23827155 MiR-25-3p attenuates the proliferation of tongue squamous cell carcinoma cell line Tca8113. -other hsa-mir-155 Atherosclerosis 23827206 MicroRNA-155 in the pathogenesis of atherosclerosis -other hsa-mir-21 "Carcinoma, Colon" 23827854 Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA-21 mediated programmed cell death 4 (PDCD4) expression. -other hsa-mir-1 Mesothelioma 23828229 miR-1 induces growth arrest and apoptosis in malignant mesothelioma. -other hsa-mir-34 Neoplasms [unspecific] 23834144 Functional role of miR-34 family in human cancer. -other hsa-mir-145 Pancreatic Neoplasms 23834149 "insulingrowth factor-1 receptor expression (miR-7, miR-139, miR-145, miR-1); " -other hsa-mir-125 Glioblastoma 23835866 MicroRNA-125b inhibitor sensitizes human primary glioblastoma cells to chemotherapeutic drug temozolomide on invasion. -other hsa-mir-34a Neoplasms [unspecific] 23836017 TP53-independent function of miR-34a via HDAC1 and p21(CIP1/WAF1.). -other hsa-mir-24 Hypertension 23836801 MicroRNA-24 is a novel regulator of aldosterone and cortisol production in the human adrenal cortex. -other hsa-mir-208 Heart Failure 23839576 "Heart function has been restored in rodents by reprogramming non-myocytes into cardiomyocytes, by expressing transcription factors (GATA4, HAND2, myocyte-specific enhancer factor 2C (MEF2C) and T-box 5 (TBX5)) and microRNAs (miR-1, miR-133, miR-208 and miR-499) that control cardiomyocyte identity." -other hsa-mir-1234 "Lymphoma, Large B-Cell, Diffuse" 23841503 Expression of microRNA-1234 related signal transducer and activator of transcription 3 in patients with diffuse large B-cell lymphoma of activated B-cell like type from high and low infectious disease areas. -other hsa-mir-148a "Carcinoma, Lung, Non-Small-Cell" 23843100 Decreased miRNA-148a is associated with lymph node metastasis and poor clinical outcomes and functions as a suppressor of tumor metastasis in non-small cell lung cancer. -other hsa-mir-142 Testicular Germ Cell Tumor 23843459 Tumor-suppressive function of protein-tyrosine phosphatase non-receptor type 23 in testicular germ cell tumors is lost upon overexpression of miR142-3p microRNA. -other hsa-mir-302b Osteosarcoma 23845851 Epirubicin-mediated expression of miR-302b is involved in osteosarcoma apoptosis and cell cycle regulation. -other hsa-mir-21 Breast Neoplasms 23851508 The anti-metastatic activity of collagenase-2 in breast cancer cells is mediated by a signaling pathway involving decorin and miR-21. -other hsa-mir-29 Neoplasms [unspecific] 23857059 miR-29 represses the activities of DNA methyltransferases and DNA demethylases. -other hsa-mir-200 "Carcinoma, Hepatocellular" 23857252 MicroRNA/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human hepatocellular carcinoma (HCC). -other hsa-mir-21 Lung Neoplasms 23857284 Expression and significance of miRNA-21 and BTG2 in lung cancer. -other hsa-mir-133a Muscle Diseases [unspecific] 23858090 miRNA analysis for the assessment of exercise and amino acid effects on human skeletal muscle. -other hsa-mir-133b Muscle Diseases [unspecific] 23858090 miRNA analysis for the assessment of exercise and amino acid effects on human skeletal muscle. -other hsa-mir-206 Muscle Diseases [unspecific] 23858090 miRNA analysis for the assessment of exercise and amino acid effects on human skeletal muscle. -other hsa-mir-499 Muscle Diseases [unspecific] 23858090 miRNA analysis for the assessment of exercise and amino acid effects on human skeletal muscle. -other hsa-mir-21 Colorectal Carcinoma 23858763 Construction of microRNA-21 and PTEN eukaryotic expression and short hairpin RNA expression vectors -other hsa-mir-1 Vascular Hypertrophy 23859766 "In addition, microRNAs (miR) -133a, miR-208 and miR-1 which were elevated following high-fat feeding were attenuated by apelin treatment." -other hsa-mir-208 Vascular Hypertrophy 23859766 "In addition, microRNAs (miR) -133a, miR-208 and miR-1 which were elevated following high-fat feeding were attenuated by apelin treatment." -other hsa-mir-124 Stroke 23860031 We highlight interactions between the miR-124 and the miR17-92 cluster and the Notch and Sonic hedgehog signaling pathways in mediating stroke-induced neurogenesis. -other hsa-mir-625 Colorectal Carcinoma 23861214 Our results suggest that miR-625 may serve as an efficient clinical biomarker and a therapeutic tool for the inhibition of metastasis in CRC. -other hsa-mir-148a "Carcinoma, Hepatocellular" 23861222 Inhibitions of epithelial to mesenchymal transition and cancer stem cells-like properties are involved in miR-148a-mediated anti-metastasis of hepatocellular carcinoma. -other hsa-mir-190 Neoplasms [unspecific] 23863200 Transcriptional changes induced by the tumor dormancy-associated microRNA-190. -other hsa-mir-143 Colorectal Carcinoma 23866094 miR-143 blocks the TLR2 signalling pathway in human CRC cells. This knowledge may pave the way for new clinical applications utilising miR-143 mimics in the treatment of patients with CRC. -other hsa-mir-221 Obesity 23867206 Our results support the link between miR-221 and obesity development as well as obesity related inflammatory status. -other hsa-mir-148a Gastric Neoplasms 23869555 Quantitative proteomics reveals diverse roles of miR-148a from gastric cancer progression to neurological development. -other hsa-mir-29b "Aortic Aneurysm, Abdominal" 23871588 MicroRNA-29b regulation of abdominal aortic aneurysm development. -other hsa-mir-499 Acute Myocardial Infarction 23872321 We developed a novel reverse-transcription real-time PCR assay for human miR-499 quantification. The good reproducibility and wide linearity range may permit more use of it in the quantification of other human miRNAs in future. -other hsa-mir-148a Gastric Neoplasms 23873106 microRNA-148a suppresses human gastric cancer cell metastasis by reversing epithelial-to-mesenchymal transition. -other hsa-mir-145 Microvascular Disease 23875242 The role of miR-145 in microvasculature. -other hsa-mir-365 Schizophrenia 23876895 "This study analyzed possible circulating miRNAs in response to antipsychotic monotherapy for schizophrenia, the further mechanism need to be confirmed." -other hsa-let-7c Lung Neoplasms 23880305 "Additionally, antrocin increased microRNA let-7c expression and suppressed STAT signaling." -other hsa-mir-127 Gastric Neoplasms 23880861 The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer. -other hsa-mir-433 Gastric Neoplasms 23880861 The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer. -other hsa-mir-122 Hepatitis C Virus Infection 23881584 miR-122 promotion of the hepatitis C virus life cycle: sound in the silence. -other hsa-mir-497 Prostate Neoplasms 23886135 MicroRNA-497 suppresses proliferation and induces apoptosis in prostate cancer cells. -other hsa-mir-485 "Carcinoma, Breast" 23886178 miR-485 acts as a tumor suppressor by inhibiting cell growth and migration in breast carcinoma T47D cells. -other hsa-mir-146a "Leukemia, Lymphoblastic, Acute" 23888320 A functional polymorphism in the miR-146a gene is associated with the risk of childhood acute lymphoblastic leukemia: a preliminary report. -other hsa-mir-200a Ovarian Neoplasms 23888941 The biphasic expression pattern of miR-200a and E-cadherin in epithelial ovarian cancer and its correlation with clinicopathological features. -other hsa-mir-99a "Adenocarcinoma, Lung" 23893385 Clinic significance of microRNA-99a expression in human lung adenocarcinoma. -other hsa-mir-30b "Scleroderma, Systemic" 23893664 Down-regulation of miR-30b might be involved in the pathogenesis of SSc. -other hsa-mir-92a Ischemia-Reperfusion Injury 23897866 Inhibition of microRNA-92a protects against ischemia/reperfusion injury in a large-animal model. -other hsa-mir-143 "Adenocarcinoma, Gastric" 23898078 Differential miRNA expression patterns of gastric adenocarcinoma of the same histopathology from a small geographic region's population show homogenous correlations with the existence of common risk factors. -other hsa-mir-203 "Adenocarcinoma, Gastric" 23898078 Differential miRNA expression patterns of gastric adenocarcinoma of the same histopathology from a small geographic region's population show homogenous correlations with the existence of common risk factors. -other hsa-mir-205 "Adenocarcinoma, Gastric" 23898078 Differential miRNA expression patterns of gastric adenocarcinoma of the same histopathology from a small geographic region's population show homogenous correlations with the existence of common risk factors. -other hsa-mir-21 "Adenocarcinoma, Gastric" 23898078 Differential miRNA expression patterns of gastric adenocarcinoma of the same histopathology from a small geographic region's population show homogenous correlations with the existence of common risk factors. -other hsa-mir-223 "Adenocarcinoma, Gastric" 23898078 Differential miRNA expression patterns of gastric adenocarcinoma of the same histopathology from a small geographic region's population show homogenous correlations with the existence of common risk factors. -other hsa-mir-34a "Adenocarcinoma, Gastric" 23898078 Differential miRNA expression patterns of gastric adenocarcinoma of the same histopathology from a small geographic region's population show homogenous correlations with the existence of common risk factors. -other hsa-mir-93 "Adenocarcinoma, Gastric" 23898078 Differential miRNA expression patterns of gastric adenocarcinoma of the same histopathology from a small geographic region's population show homogenous correlations with the existence of common risk factors. -other hsa-mir-29a Pancreatic Neoplasms 23900458 MicroRNA-29a induces resistance to gemcitabine through the Wnt/¦Â-catenin signaling pathway in pancreatic cancer cells. -other hsa-mir-29 Neoplasms [unspecific] 23901138 miR-29 acts as a decoy in sarcomas to protect the tumor suppressor A20 mRNA from degradation by HuR. -other hsa-mir-210 "Carcinoma, Renal Cell" 23902947 "VHL, involved in tumorigenesis of PGLs and clear cell renal cell carcinomas, may be an important player in the pathogenesis of sporadic HNPGLs via activation of an HIF-1¦Á/miR-210 pHx pathway." -other hsa-mir-29 Ovarian Neoplasms 23904094 Downregulation of miR-29 contributes to cisplatin resistance of ovarian cancer cells. -other hsa-mir-21 Glioblastoma 23907387 "Furthermore, several modules associated with less well-reported molecular aberrations-such as chromosome 11 CNVs, CD40, PLXNB1 and GSTM1 methylations, and mir-21 expressions-were also validated by external information. " -other hsa-mir-100 Bladder Neoplasms 23911686 Aberrations in miR expression identified between non-muscle invasive BC and muscle-invasive BC provide insight into the molecular alterations known to distinguish the two parallel pathways of bladder carcinogenesis. The heterogeneity of tumor specimens and research methods limits the reproducibility of changes in miR expression profiles between studies and underscores theimportance of in vivo validation in a field that utilizes in silico miR target-prediction models. -other hsa-mir-101 Bladder Neoplasms 23911686 Aberrations in miR expression identified between non-muscle invasive BC and muscle-invasive BC provide insight into the molecular alterations known to distinguish the two parallel pathways of bladder carcinogenesis. The heterogeneity of tumor specimens and research methods limits the reproducibility of changes in miR expression profiles between studies and underscores theimportance of in vivo validation in a field that utilizes in silico miR target-prediction models. -other hsa-mir-145 Bladder Neoplasms 23911686 Aberrations in miR expression identified between non-muscle invasive BC and muscle-invasive BC provide insight into the molecular alterations known to distinguish the two parallel pathways of bladder carcinogenesis. The heterogeneity of tumor specimens and research methods limits the reproducibility of changes in miR expression profiles between studies and underscores theimportance of in vivo validation in a field that utilizes in silico miR target-prediction models. -other hsa-mir-21 Bladder Neoplasms 23911686 Aberrations in miR expression identified between non-muscle invasive BC and muscle-invasive BC provide insight into the molecular alterations known to distinguish the two parallel pathways of bladder carcinogenesis. The heterogeneity of tumor specimens and research methods limits the reproducibility of changes in miR expression profiles between studies and underscores theimportance of in vivo validation in a field that utilizes in silico miR target-prediction models. -other hsa-mir-373 Bladder Neoplasms 23911686 Aberrations in miR expression identified between non-muscle invasive BC and muscle-invasive BC provide insight into the molecular alterations known to distinguish the two parallel pathways of bladder carcinogenesis. The heterogeneity of tumor specimens and research methods limits the reproducibility of changes in miR expression profiles between studies and underscores theimportance of in vivo validation in a field that utilizes in silico miR target-prediction models. -other hsa-mir-99a Bladder Neoplasms 23911686 Aberrations in miR expression identified between non-muscle invasive BC and muscle-invasive BC provide insight into the molecular alterations known to distinguish the two parallel pathways of bladder carcinogenesis. The heterogeneity of tumor specimens and research methods limits the reproducibility of changes in miR expression profiles between studies and underscores theimportance of in vivo validation in a field that utilizes in silico miR target-prediction models. -other hsa-mir-106b "Carcinoma, Laryngeal" 23912048 MicroRNA-106b regulates the tumor suppressor RUNX3 in laryngeal carcinoma cells. -other hsa-mir-17 "Carcinoma, Hepatocellular" 23912452 Thyroid hormone receptor represses miR-17 expression to enhance tumor metastasis in human hepatoma cells. -other hsa-mir-31 Chordoma 23912551 MicroRNA expression profiling reveals the potential function of microRNA-31 in chordomas. -other hsa-mir-224 "Carcinoma, Hepatocellular" 23913306 "A noncanonical pathway links autophagy,miR-224, Smad4, and HBV-associated HCC. These findings open a new avenue for the treatment of HCC." -other hsa-mir-100 "Leukemia, Lymphoblastic, Acute" 23915977 "MiR-125b, miR-100 and miR-99a co-regulate vincristine resistance in childhood acute lymphoblastic leukemia." -other hsa-mir-125b "Leukemia, Lymphoblastic, Acute" 23915977 "MiR-125b, miR-100 and miR-99a co-regulate vincristine resistance in childhood acute lymphoblastic leukemia." -other hsa-mir-99a "Leukemia, Lymphoblastic, Acute" 23915977 "MiR-125b, miR-100 and miR-99a co-regulate vincristine resistance in childhood acute lymphoblastic leukemia." -other hsa-mir-34c Neoplasms [unspecific] 23922103 These findings provide a novel molecular mechanism of MET regulation in PCa and contribute to the increasing evidence that miR-34c has a key tumour suppressive role in PCa. -other hsa-mir-768 Lung Neoplasms 23928793 The brain microenvironment negatively regulates miRNA-768-3p to promote K-ras expression and lung cancer metastasis. -other hsa-mir-515 Breast Neoplasms 23928990 Downregulation of microRNA-515-5p by the estrogen receptor modulates sphingosine kinase 1 and breast cancer cell proliferation. -other hsa-mir-148a Colorectal Carcinoma 23933284 Clinical significance of microRNA-148a in patients with early relapse of stage II stage and III colorectal cancer after curative resection. -other hsa-mir-192 Influenza 23934176 MicroRNA-based strategy to mitigate the risk of gain-of-function influenza studies. -other hsa-mir-24 Multiple Myeloma 23934711 Contribution of microRNA 24-3p and Erk1/2 to interleukin-6 mediated plasma cell survival. -other hsa-mir-202 Gastric Neoplasms 23936094 "Decrease of miR-202-3p expression, a novel tumor suppressor, in gastric cancer." -other hsa-mir-140 Osteoarthritis 23942573 Molecular mechanisms of the cartilage-specific microRNA-140 in osteoarthritis. -other hsa-mir-29c Glioma 23943502 "MiR-29c inhibits glioma cell proliferation, migration, invasion and angiogenesis." -other hsa-mir-221 Asthma 23944957 Airway smooth muscle hyperproliferation is regulated by microRNA-221 in severe asthma. -other hsa-mir-100 Bladder Neoplasms 23945108 miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome. -other hsa-mir-29c Multiple Sclerosis 23946286 MicroRNA-29c in urinary exosome/microvesicle as a biomarker of renal fibrosis. -other hsa-mir-186 "Carcinoma, Endometrioid Endometrial" 23946815 "The qRT-PCR analysis further identified a profile of four serum miRNAs (miR-222, miR-223, miR-186 and miR-204) as a fingerprint for EEC detection." -other hsa-mir-155 Immune System Disease [unspecific] 23949802 MicroRNA-155 drives TH17 immune response and tissue injury in experimental crescentic GN. -other hsa-mir-153 Colorectal Carcinoma 23950211 miR-153 supports colorectal cancer progression via pleiotropic effects that enhance invasion and chemotherapeutic resistance. -other hsa-mir-106a Colorectal Carcinoma 23950216 Fecal miR-106a is a good molecular marker to identify colorectal cancer patients from among those with negative iFOBT results. FmiRT combined with iFOBT may improve the sensitivity to detect colorectal cancer. -other hsa-mir-105 Neoplasms [unspecific] 23950948 miR-105 inhibits prostate tumour growth by suppressing CDK6 levels. -other hsa-mir-185 Prostate Neoplasms 23951060 MicroRNA-185 and 342 inhibit tumorigenicity and induce apoptosis through blockade of the SREBP metabolic pathway in prostate cancer cells. -other hsa-mir-342 Prostate Neoplasms 23951060 MicroRNA-185 and 342 inhibit tumorigenicity and induce apoptosis through blockade of the SREBP metabolic pathway in prostate cancer cells. -other hsa-mir-136 "Carcinoma, Lung, Non-Small-Cell" 23959478 "miR-146a-5p circuitry uncouples cell proliferation and migration, but not differentiation, in human mesenchymal stem cells." -other hsa-mir-214 "Carcinoma, Hepatocellular" 23962428 Downregulation of microRNA-214 and overexpression of FGFR-1 contribute to hepatocellular carcinoma metastasis. -other hsa-mir-137 Huntington Disease 23965969 "Regulation of huntingtin gene expression by miRNA-137, -214, -148a, and their respective isomiRs." -other hsa-mir-148a Huntington Disease 23965969 "Regulation of huntingtin gene expression by miRNA-137, -214, -148a, and their respective isomiRs." -other hsa-mir-214 Huntington Disease 23965969 "Regulation of huntingtin gene expression by miRNA-137, -214, -148a, and their respective isomiRs." -other hsa-mir-503 "Carcinoma, Hepatocellular" 23967867 "Our data highlight an important role for miR-503 in cell cycle regulation and in the molecular etiology of HCC, and implicate the potential application of miR-503 in prognosis prediction and miRNA-based HCC therapy." -other hsa-mir-133a Colorectal Carcinoma 23968734 "miR-133a may play a key role in CRC genesis and metastasis, which suggests its potential role in the molecular therapy of cancer." -other hsa-mir-222 Lung Neoplasms 23974492 Metformin inhibits lung cancer cells proliferation through repressing microRNA-222. -other hsa-mir-17 "Lymphoma, Large-Cell, Anaplastic" 23975180 The microRNA-17~92 cluster is involved in lymphomagenesis of STAT3(+) ALCL and that its inhibition might represent an alternative avenue to interfere with ALK signaling in anaplastic large cell lymphomas. -other hsa-mir-21 Renal Fibrosis 23978520 Microvesicle-mediated delivery of miR-21 among tubular epithelial cells might shed new light on the mechanism of progressive renal fibrosis. -other hsa-mir-26b "Lymphoma, Non-Hodgkin" 23978716 Hepatitis C-associated B-cell non-Hodgkin lymphomas: the emerging role of miRNA-26b. -other hsa-mir-433 Liver Neoplasms 23979134 MicroRNA-433 inhibits liver cancer cell migration by repressing the protein expression and function of cAMP response element-binding protein. -other hsa-mir-338 Neurodegenerative Diseases [unspecific] 23979835 "The EnSCs can differentiate to oligodendrocyte cells by the overexpression of miR-338, and these cells can be used as a unique source for cell therapy of neurodegenerative disease." -other hsa-mir-486 Lung Neoplasms 23980150 "Insulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNA in lung cancer." -other hsa-mir-21 Kidney Neoplasms 23981302 NF¦ÊB-mediated cyclin D1 expression by microRNA-21 influences renal cancer cell proliferation. -other hsa-mir-23 Kaposi Sarcoma 23986579 Kaposi's sarcoma-associated herpesvirus encodes a mimic of cellular miR-23. -other hsa-mir-34a "Carcinoma, Colon" 23991105 MicroRNA-34a mediates the autocrine signaling of PAR2-activating proteinase and its role in colonic cancer cell proliferation. -other hsa-mir-16 Bladder Neoplasms 23991964 "miR-16 is an important regulator in bladder cancer, which will contribute to better understanding of important mis-regulated miRNAs." -other hsa-mir-222 Breast Neoplasms 23994196 MiR-222 and miR-29a contribute to the drug-resistance of breast cancer cells. -other hsa-mir-29a Breast Neoplasms 23994196 MiR-222 and miR-29a contribute to the drug-resistance of breast cancer cells. -other hsa-mir-216a Acute Pancreatitis 23995054 MiR-216a and miR-216b as markers for acute phased pancreatic injury. -other hsa-mir-216b Acute Pancreatitis 23995054 MiR-216a and miR-216b as markers for acute phased pancreatic injury. -other hsa-mir-126 Colorectal Adenocarcinoma 23996930 Pomegranate polyphenolics suppressed azoxymethane-induced colorectal aberrant crypt foci and inflammation: possible role of miR-126/VCAM-1 and miR-126/PI3K/AKT/mTOR. -other hsa-mir-21 "Carcinoma, Lung" 24004609 "Arsenite evokes IL-6 secretion, autocrine regulation of STAT3 signaling, and miR-21 expression, processes involved in the EMT and malignant transformation of human bronchial epithelial cells." -other hsa-mir-149 "Carcinoma, Lung, Non-Small-Cell" 24007627 A two miRNA signature (miR-149 and miR-375) was found predictive for response and was also associated to progression-free survival (p = 0.05). -other hsa-mir-1288 Colorectal Carcinoma 24009195 Regulation of microRNA-1288 in colorectal cancer: altered expression and its clinicopathological significance. -other hsa-mir-27a Ischemia-Reperfusion Injury 24009229 Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27. -other hsa-mir-21 Lung Neoplasms 24012885 "Angiogenesis, mediated by miR-21, is involved arsenite-induced carcinogenesis." -other hsa-mir-146a Autoimmune Diseases [unspecific] 24014244 Our data unravel the crucial immunomodulatory role of miR-146a in pDCs and may add to our understanding of aberrant responses in autoimmune diseases. -other hsa-mir-7 Neoplasms [unspecific] 24014594 "we review the current knowledge about the ciRS-7/miR-7 axis in cancer-related pathways and discuss possible models explaining the relevance of coexpressing miR-7 along with a circRNA inhibitor. c-mir-221-3p,c-mir-223-3p" -other hsa-mir-200 Neoplasms [unspecific] 24018975 The role of miR-200 in blocking cancer angiogenesis in a cancer-dependent context defines its utility as a potential therapeutic agent. -other hsa-mir-34a Lung Neoplasms 24019906 the highly tumorigenic CD44(hi) cells are enriched for cells in the G2 phase of cell cycle. -other hsa-mir-126 Atherosclerosis 24022569 "Increased miR-146a and miR-126 and reduced miR-155 levels were observed in both treatment groups (all, P<0.001)" -other hsa-mir-204 Pancreatic Neoplasms 24025188 Triptolide mediated miR-204 increase causes pancreatic cancer cell death via loss of Mcl-1. -other hsa-mir-145 "Adenocarcinoma, Lung" 24026105 miR-145 may have a cell type-specific function and play important roles in the process of BM from lung adenocarcinoma. -other hsa-mir-222 Pancreatic Neoplasms 24026657 "This study provides the first evidence of a potential link between Ki67 and micro-RNA-222, which are both relevant to cell proliferation. Our data suggest the potential of micro-RNA-222 as a prognostic biomarker for the pancreatic cancer." -other hsa-mir-130b Colorectal Carcinoma 24027433 MicroRNA-130b promotes tumor development and is associated with poor prognosis in colorectal cancer. -other hsa-mir-30 Glomerulonephritis 24029422 Downregulation of microRNA-30 facilitates podocyte injury and is prevented by glucocorticoids. -other hsa-mir-126 "Lymphoma, T-Cell, Cutaneous" 24033365 "Taken together, our findings suggest that both malignant and non-malignant T cells express miR-155 in situ in CTCL. Moreover, they indicate heterogeneity in miR-155 expression among malignant T cells." -other hsa-mir-155 "Lymphoma, T-Cell, Cutaneous" 24033365 "Taken together, our findings suggest that both malignant and non-malignant T cells express miR-155 in situ in CTCL. Moreover, they indicate heterogeneity in miR-155 expression among malignant T cells." -other hsa-mir-146 Inflammation 24035832 Our findings reveal a novel regulatory module of two miRNA-mediated negative feedback loops that allows for the fine-tuning of the dynamics of key mediators in inflammation. -other hsa-mir-21 Inflammation 24035832 Our findings reveal a novel regulatory module of two miRNA-mediated negative feedback loops that allows for the fine-tuning of the dynamics of key mediators in inflammation. -other hsa-mir-221 Melanoma 24035906 we report the production of circular microRNA sponges against miR-21 or miR-221 in cell lines using the self-splicing permuted intron-exon sequences derived from T4 bacteriophage gene td. -other hsa-mir-146a Myasthenia Gravis 24036458 We conclude that abnormal expression/regulation of miR-146a may play an important role in the regulation of AchR specific B cells and contribute to the pathogenesis of MG. -other hsa-mir-144 Muscle Diseases [unspecific] 24036467 Our results reveal that there are changes in expression of known and novel miRNAs with skeletal muscle aging and that CR may reverse some of these changes to a younger phenotype. -other hsa-mir-15a Muscle Diseases [unspecific] 24036467 Our results reveal that there are changes in expression of known and novel miRNAs with skeletal muscle aging and that CR may reverse some of these changes to a younger phenotype. -other hsa-mir-181b Muscle Diseases [unspecific] 24036467 Our results reveal that there are changes in expression of known and novel miRNAs with skeletal muscle aging and that CR may reverse some of these changes to a younger phenotype. -other hsa-mir-18a Muscle Diseases [unspecific] 24036467 Our results reveal that there are changes in expression of known and novel miRNAs with skeletal muscle aging and that CR may reverse some of these changes to a younger phenotype. -other hsa-mir-451 Muscle Diseases [unspecific] 24036467 Our results reveal that there are changes in expression of known and novel miRNAs with skeletal muscle aging and that CR may reverse some of these changes to a younger phenotype. -other hsa-mir-200 Breast Neoplasms 24037528 MiR-200 can repress breast cancer metastasis through ZEB1-independent but moesin-dependent pathways. -other hsa-mir-103 Polycystic Ovarian Syndrome 24037889 The present results suggest that miRNAs that play an important role in metabolic and immune system processes are influenced by obesity and circulating androgen concentrations. -other hsa-mir-155 Polycystic Ovarian Syndrome 24037889 The present results suggest that miRNAs that play an important role in metabolic and immune system processes are influenced by obesity and circulating androgen concentrations. -other hsa-mir-21 Polycystic Ovarian Syndrome 24037889 The present results suggest that miRNAs that play an important role in metabolic and immune system processes are influenced by obesity and circulating androgen concentrations. -other hsa-mir-27b Polycystic Ovarian Syndrome 24037889 The present results suggest that miRNAs that play an important role in metabolic and immune system processes are influenced by obesity and circulating androgen concentrations. -other hsa-mir-495 "Carcinoma, Lung, Non-Small-Cell" 24038379 miR-495 enhances the sensitivity of non-small cell lung cancer cells to platinum by modulation of copper-transporting P-type adenosine triphosphatase A (ATP7A). -other hsa-mir-151 Myocardial Infarction 24039836 Downregulation of miR-151-5p contributes to increased susceptibility to arrhythmogenesis during myocardial infarction with estrogen deprivation. -other hsa-mir-21 "Squamous Cell Carcinoma, Esophageal" 24039846 "MiR-21 expression is mostly confined to the SCC stroma and its release from fibroblasts influences the migration and invasion capacity of SCC cells. Moreover, miR-21 may be an important factor in activating fibroblasts to CAFs. These findings provide new insights into the role of CAFs and the extracellular matrix in tumor microenvironment formation and in tumor cell maintenance, and suggest miR-21 may contribute to cellular crosstalk in the tumor microenvironment." -other hsa-mir-31 "Squamous Cell Carcinoma, Esophageal" 24039884 Dissection of miRNA-miRNA interaction in esophageal squamous cell carcinoma. -other hsa-mir-338 "Squamous Cell Carcinoma, Esophageal" 24039884 Dissection of miRNA-miRNA interaction in esophageal squamous cell carcinoma. -other hsa-let-7a Pancreatic Neoplasms 24040120 DCLK1 regulates pluripotency and angiogenic factors via microRNA-dependent mechanisms in pancreatic cancer. -other hsa-mir-145 Pancreatic Neoplasms 24040120 DCLK1 regulates pluripotency and angiogenic factors via microRNA-dependent mechanisms in pancreatic cancer. -other hsa-mir-200 Pancreatic Neoplasms 24040120 DCLK1 regulates pluripotency and angiogenic factors via microRNA-dependent mechanisms in pancreatic cancer. -other hsa-mir-21 Neoplasms [unspecific] 24041029 Here we summarize current knowledge on miR-21 functions in human cancers and discuss how this finding provides insight into the role of miR-21 as an oncogenic regulator in stem/progenitor cell populations of human cancers. -other hsa-mir-125a Lung Neoplasms 24044511 MicroRNA hsa-miR-125a-3p activates p53 and induces apoptosis in lung cancer cells. -other hsa-mir-122 "Leukemia, Lymphocytic, Chronic, B-Cell" 24047131 Four-way junction formation promoting ultrasensitive electrochemical detection of microRNA. -other hsa-mir-100 Vulvar Squamous Cell Carcinoma 24048714 "In conclusion, our study demonstrates that microRNAs may be clinically important in vulvar carcinomas and our findings may help for further studies on functional implications of miRNA deregulation in this type of cancer." -other hsa-mir-133a Vulvar Squamous Cell Carcinoma 24048714 "In conclusion, our study demonstrates that microRNAs may be clinically important in vulvar carcinomas and our findings may help for further studies on functional implications of miRNA deregulation in this type of cancer." -other hsa-mir-19b-1 Vulvar Squamous Cell Carcinoma 24048714 "In conclusion, our study demonstrates that microRNAs may be clinically important in vulvar carcinomas and our findings may help for further studies on functional implications of miRNA deregulation in this type of cancer." -other hsa-mir-223 Vulvar Squamous Cell Carcinoma 24048714 "In conclusion, our study demonstrates that microRNAs may be clinically important in vulvar carcinomas and our findings may help for further studies on functional implications of miRNA deregulation in this type of cancer." -other hsa-mir-519b Vulvar Squamous Cell Carcinoma 24048714 "In conclusion, our study demonstrates that microRNAs may be clinically important in vulvar carcinomas and our findings may help for further studies on functional implications of miRNA deregulation in this type of cancer." -other hsa-mir-29 Liver Injury 24052410 "Our results indicate that miR-29a decreases cholestatic liver injury and fibrosis after BDL, at least partially, by modulating the extrinsic rather than intrinsic pathway of apoptosis." -other hsa-mir-1321 Pediatric Glioma 24053158 In the present study we identified the changed expression pattern of microRNAs in pediatric gliamas. Our study also provides a better understanding of pediatric brain tumor biology and may assist in the development of less toxic therapies and in the search for better markers for disease stratification. -other hsa-mir-513b Pediatric Glioma 24053158 In the present study we identified the changed expression pattern of microRNAs in pediatric gliamas. Our study also provides a better understanding of pediatric brain tumor biology and may assist in the development of less toxic therapies and in the search for better markers for disease stratification. -other hsa-mir-769 Pediatric Glioma 24053158 In the present study we identified the changed expression pattern of microRNAs in pediatric gliamas. Our study also provides a better understanding of pediatric brain tumor biology and may assist in the development of less toxic therapies and in the search for better markers for disease stratification. -other hsa-mir-29 Crohn Disease 24054330 The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release. -other hsa-mir-129 Gastric Neoplasms 24055727 Growth inhibitory effects of three miR-129 family members on gastric cancer. -other hsa-mir-1246 "Carcinoma, Hepatocellular" 24060847 The manipulation of one or more of these miRNAs could be an important approach for the improved management of paclitaxel therapy. -other hsa-mir-1260b "Carcinoma, Hepatocellular" 24060847 The manipulation of one or more of these miRNAs could be an important approach for the improved management of paclitaxel therapy. -other hsa-mir-1274a "Carcinoma, Hepatocellular" 24060847 The manipulation of one or more of these miRNAs could be an important approach for the improved management of paclitaxel therapy. -other hsa-mir-1290 "Carcinoma, Hepatocellular" 24060847 The manipulation of one or more of these miRNAs could be an important approach for the improved management of paclitaxel therapy. -other hsa-mir-183 "Carcinoma, Hepatocellular" 24060847 The manipulation of one or more of these miRNAs could be an important approach for the improved management of paclitaxel therapy. -other hsa-mir-21 "Carcinoma, Hepatocellular" 24060847 The manipulation of one or more of these miRNAs could be an important approach for the improved management of paclitaxel therapy. -other hsa-mir-508 "Carcinoma, Hepatocellular" 24060847 The manipulation of one or more of these miRNAs could be an important approach for the improved management of paclitaxel therapy. -other hsa-mir-877 "Carcinoma, Hepatocellular" 24060847 The manipulation of one or more of these miRNAs could be an important approach for the improved management of paclitaxel therapy. -other hsa-mir-126 Allergy 24063594 "Expression kinetics of miRNA involved in dermal toluene 2,4-diisocyanate sensitization." -other hsa-mir-155 Allergy 24063594 "Expression kinetics of miRNA involved in dermal toluene 2,4-diisocyanate sensitization." -other hsa-mir-21 Allergy 24063594 "Expression kinetics of miRNA involved in dermal toluene 2,4-diisocyanate sensitization." -other hsa-mir-210 Allergy 24063594 "Expression kinetics of miRNA involved in dermal toluene 2,4-diisocyanate sensitization." -other hsa-mir-22 Allergy 24063594 "Expression kinetics of miRNA involved in dermal toluene 2,4-diisocyanate sensitization." -other hsa-mir-27b Allergy 24063594 "Expression kinetics of miRNA involved in dermal toluene 2,4-diisocyanate sensitization." -other hsa-mir-31 Allergy 24063594 "Expression kinetics of miRNA involved in dermal toluene 2,4-diisocyanate sensitization." -other hsa-mir-1290 Celiac Disease 24063611 microRNA profiles in coeliac patients distinguish different clinical phenotypes and are modulated by gliadin peptides in primary duodenal fibroblasts. -other hsa-mir-192 Celiac Disease 24063611 microRNA profiles in coeliac patients distinguish different clinical phenotypes and are modulated by gliadin peptides in primary duodenal fibroblasts. -other hsa-mir-194 Celiac Disease 24063611 microRNA profiles in coeliac patients distinguish different clinical phenotypes and are modulated by gliadin peptides in primary duodenal fibroblasts. -other hsa-mir-31 Celiac Disease 24063611 microRNA profiles in coeliac patients distinguish different clinical phenotypes and are modulated by gliadin peptides in primary duodenal fibroblasts. -other hsa-mir-551a Celiac Disease 24063611 microRNA profiles in coeliac patients distinguish different clinical phenotypes and are modulated by gliadin peptides in primary duodenal fibroblasts. -other hsa-mir-551b Celiac Disease 24063611 microRNA profiles in coeliac patients distinguish different clinical phenotypes and are modulated by gliadin peptides in primary duodenal fibroblasts. -other hsa-mir-638 Celiac Disease 24063611 microRNA profiles in coeliac patients distinguish different clinical phenotypes and are modulated by gliadin peptides in primary duodenal fibroblasts. -other hsa-mir-144 "Carcinoma, Lung, Non-Small-Cell" 24066116 "Our results for the first time showed mir-144-ZFX pathway is involved in the development of NSCLC, which sheds a light for further investigations on underlying mechanisms toward better understanding and management of NSCLC." -other hsa-mir-199 Liver Neoplasms 24069256 "We exploited this miR-199 differential expression to develop a conditionally replication-competent oncolytic adenovirus, Ad-199T, and achieve tumor-specific viral expression and replication. " -other hsa-mir-23b Pancreatic Adenocarcinoma 24070722 "Mir-23B might be used as a biomarker for PDAC resistance to radiotherapy or chemotherapy. Or, patients with low tumor levels of Mir-23B might benefit from pharmacologic inhibitors of autophagy." -other hsa-let-7 Squamous Cell Carcinoma 24070899 "Phospho-¦¤Np63¦Á regulates AQP3, ALOX12B, CASP14 and CLDN1 expression through transcription and microRNA modulation." -other hsa-mir-143 "Carcinoma, Endometrial" 24071015 Down-regulation of miR-145 and miR-143 might be associated with DNA methyltransferase 3B overexpression and worse prognosis in endometrioid carcinomas. -other hsa-mir-145 "Carcinoma, Endometrial" 24071015 Down-regulation of miR-145 and miR-143 might be associated with DNA methyltransferase 3B overexpression and worse prognosis in endometrioid carcinomas. -other hsa-mir-151 Hantavirus Infection 24074584 Our data suggest that differential immune responses following hantavirus infection may be regulated in part by cellular miRNA through dysregulation of genes critical to the inflammatory process. -other hsa-mir-1973 Hantavirus Infection 24074584 Our data suggest that differential immune responses following hantavirus infection may be regulated in part by cellular miRNA through dysregulation of genes critical to the inflammatory process. -other hsa-mir-182 "Carcinoma, Ovarian, Serous" 24077281 "We describe several mechanisms responsible for FOXO3a inactivity, including chromosomal deletion (chromosome 6q21), upregulation of miRNA-182 and destabilization by activated PI3K and MEK." -other hsa-mir-182 Choriocarcinoma 24078156 " We have also shown the alterations in expressing profile of miR-31, miR-133a, miR-141, miR-145, miR-149, miR-182 and miR-194, which were observed even in the early stage of disease, and identified a set of genes, which take place in correct assigning of patients in dependence of CRC stage." -other hsa-mir-194 Choriocarcinoma 24078156 " We have also shown the alterations in expressing profile of miR-31, miR-133a, miR-141, miR-145, miR-149, miR-182 and miR-194, which were observed even in the early stage of disease, and identified a set of genes, which take place in correct assigning of patients in dependence of CRC stage." -other hsa-mir-31 Choriocarcinoma 24078156 " We have also shown the alterations in expressing profile of miR-31, miR-133a, miR-141, miR-145, miR-149, miR-182 and miR-194, which were observed even in the early stage of disease, and identified a set of genes, which take place in correct assigning of patients in dependence of CRC stage." -other hsa-mir-34a Preeclampsia 24081307 "The results support a role for miR-34a in the pathophysiology of preeclampsia, through deregulation of the pri-miRNA expression and its altered maturation." -other hsa-mir-29 Atrial Fibrillation 24085039 These new insights into mir29¡¯s functions further support a role for the adaptive immune system in the immunopathogenesis of AF. We recommend that AF investigators team up with immunologists in search for pathogenic T cells. -other hsa-mir-33 Atherosclerosis 24086374 "These results reveal a novel mechanism for the BA-mediated ABCA1 expression, which may provide new insights for developing strategies for modulating vascular inflammation and atherosclerosis." -other hsa-mir-200a Breast Neoplasms 24086551 "MiR-200b eRNA may be involved in the regulation of miR-200b~200a~429 gene expression and silencing. Taken together, these findings reveal the presence of a novel enhancer, which contributes to miR-200b~200a~429 transcriptional regulation in epithelial cells." -other hsa-mir-200b Breast Neoplasms 24086551 "MiR-200b eRNA may be involved in the regulation of miR-200b~200a~429 gene expression and silencing. Taken together, these findings reveal the presence of a novel enhancer, which contributes to miR-200b~200a~429 transcriptional regulation in epithelial cells." -other hsa-mir-429 Breast Neoplasms 24086551 "MiR-200b eRNA may be involved in the regulation of miR-200b~200a~429 gene expression and silencing. Taken together, these findings reveal the presence of a novel enhancer, which contributes to miR-200b~200a~429 transcriptional regulation in epithelial cells." -other hsa-mir-150 "Leukemia, Acute" 24086639 "miR-150 promotes myeloid differentiation, a previously uncharacterized role for this miRNA, and that absent or low miR-150 expression contributes to blocked myeloid differentiation in acute leukemia cells." -other hsa-mir-1227 Prostate Neoplasms 24091630 "Large oncosomes enhanced migration of cancer-associated fibroblasts (CAFs), an effect that was increased by miR-1227, a miRNA abundant in large oncosomes produced by RWPE-2 cells. " -other hsa-mir-34a Malignant Neoplasms [unspecific] 24091633 miR-34a can potentially be exploited for DNA damage-effecting therapies of malignancies. -other hsa-mir-29b Multiple Myeloma 24091729 miR-29b is endowed with epigenetic activity and mediates previously unknown functions of bortezomib in MM cells. -other hsa-mir-210 Neoplasms [unspecific] 24098326 hypoxia related mir-210 and apoptosis-related mir-296-5p in the cancer mechanisms -other hsa-mir-296 Neoplasms [unspecific] 24098326 hypoxia related mir-210 and apoptosis-related mir-296-5p in the cancer mechanisms -other hsa-mir-125b Breast Neoplasms 24098452 "The expression of ENPEP and CK2-¦Á was inversely correlated with miR-125b expression in breast tumors,indicating the relevance of these potential oncogenic proteins in breast cancer patients. " -other hsa-mir-210 Leishmaniasis 24098824 MicroRNA expression profile in human macrophages in response to Leishmania major infection. -other hsa-mir-92b "Carcinoma, Lung, Non-Small-Cell" 24099768 "The miR-92b play an oncogene roles by regulatescell growth, cisplatin chemosensitivity phenotype, and could serve as a novel potential maker for NSCLC therapy." -other hsa-mir-33a Liver Fibrosis 24100264 "the expression of miR-33a increased with the progression of liver fibrosis. These results suggested that anti-miR-33a inhibit activation and extracellular matrix production, at least in part, via the activation of PI3K/Akt pathway and PPAR-¦Á and anti sense of miR-33a may be a novel potential therapeutic approach for treating hepatic fibrosis in the future." -other hsa-mir-29a Human Immunodeficiency Virus Infection 24103357 "The lack of significant negative correlation of miR-29a and TTP expression levels suggests that while miR-29a may contribute to TTP regulation, additional factors are involved. Reduced TTP expression during acute infection is consistent with increased cytokine production during this phase of infection, but the increases in TTP observed during late-stage infection were insufficient to halt runaway cytokine levels." -other hsa-let-7a Breast Neoplasms 24104964 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. -other hsa-let-7b Breast Neoplasms 24104964 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. -other hsa-let-7c Breast Neoplasms 24104964 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. -other hsa-let-7d Breast Neoplasms 24104964 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. -other hsa-let-7f Breast Neoplasms 24104964 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. -other hsa-let-7g Breast Neoplasms 24104964 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. -other hsa-let-7i Breast Neoplasms 24104964 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. -other hsa-mir-141 Hereditary Breast Carcinoma 24104964 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. -other hsa-mir-15a Hereditary Breast Carcinoma 24104964 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. -other hsa-mir-15b Hereditary Breast Carcinoma 24104964 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. -other hsa-mir-16 Hereditary Breast Carcinoma 24104964 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. -other hsa-mir-195 Hereditary Breast Carcinoma 24104964 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. -other hsa-mir-200a Hereditary Breast Carcinoma 24104964 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. -other hsa-mir-200b Hereditary Breast Carcinoma 24104964 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. -other hsa-mir-200c Hereditary Breast Carcinoma 24104964 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. -other hsa-mir-29a Hereditary Breast Carcinoma 24104964 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. -other hsa-mir-29b Hereditary Breast Carcinoma 24104964 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. -other hsa-mir-29c Hereditary Breast Carcinoma 24104964 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. -other hsa-mir-30a Hereditary Breast Carcinoma 24104964 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. -other hsa-mir-30b Hereditary Breast Carcinoma 24104964 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. -other hsa-mir-30c Hereditary Breast Carcinoma 24104964 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. -other hsa-mir-30d Hereditary Breast Carcinoma 24104964 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. -other hsa-mir-30e Hereditary Breast Carcinoma 24104964 Our data demonstrate that BRCAX hereditary breast tumours can be sub-classified into four previously unknown homogenous groups characterised by specific miRNA expression signatures and histopathological features. -other hsa-mir-143 Sepsis 24105952 "The toll-like receptor 3 ligand, poly(I:C), improves immunosuppressive function and therapeutic effect of mesenchymal stem cells on sepsis via inhibiting MiR-143." -other hsa-mir-122 Hepatitis C Virus Infection 24106328 "By use of duplex and precursor miR-122 mimetic molecules that carried mutations in the passenger strand of miR-122, the effects on viral and reporter gene expression could be pinpointed to the action of precursor miR-122 molecules." -other hsa-mir-29a "Scleroderma, Systemic" 24107002 Hair miR-29a levels are decreased in patients with scleroderma. -other hsa-mir-196a-2 Colorectal Carcinoma 24107909 Meta-analysis of the association between a polymorphism in microRNA-196a2 and susceptibility to colorectal cancer. -other hsa-mir-9 Viral Infectious Disease 24109243 Human coronavirus OC43 nucleocapsid protein binds microRNA 9 and potentiates NF-¦ÊB activation. -other hsa-mir-21 "Carcinoma, Hepatocellular" 24112539 MicroRNA-21 promotes hepatocellular carcinoma HepG2 cell proliferation through repression of mitogen-activated protein kinase-kinase 3. -other hsa-mir-122 Liver Injury 24118944 M65 and microRNA-122 are potential biomarkers of DILI superior to ALT with respect to sensitivity and specificity. -other hsa-mir-378 "Squamous Cell Carcinoma, Oral" 24120010 MicroRNA in oral squamous cell carcinoma -other hsa-mir-122 Liver Diseases [unspecific] 24121065 miR-122 is a liver-specific microRNA associated with many liver diseases -other hsa-mir-155 Neoplasms [unspecific] 24122356 microRNA-155 has functions in the control of various cancers -other hsa-mir-101 Liver Neoplasms 24123132 Another myc in the wall: microRNA-101 controls important functions in liver cancer formation. -other hsa-mir-483 "Carcinoma, Hepatocellular" 24127413 Exploration of genome-wide circulating microRNA in hepatocellular carcinoma:MiR-483-5p as a potential biomarker. -other hsa-mir-122 "Carcinoma, Hepatocellular" 24130799 The continued expression of miR-122 in HCV-associated HCC may signify an important role for HCV replication late in the progression to malignancy. -other hsa-mir-106b Prostate Neoplasms 24135225 Down-regulation of RE-1 silencing transcription factor (REST) in advanced prostate cancer by hypoxia-induced miR-106b~25. -other hsa-mir-141 "Carcinoma, Hepatocellular" 24135722 Simultaneous silencing of miR-200c and miR-141 was likely to be responsible for the development of HCC-BDTT via ZEB1-directed EMT activation and Sec24a-mediated secretome. -other hsa-mir-200 "Carcinoma, Hepatocellular" 24135722 Simultaneous silencing of miR-200c and miR-141 was likely to be responsible for the development of HCC-BDTT via ZEB1-directed EMT activation and Sec23a-mediated secretome. -other hsa-mir-200c "Carcinoma, Hepatocellular" 24135722 Simultaneous silencing of miR-200c and miR-141 was likely to be responsible for the development of HCC-BDTT via ZEB1-directed EMT activation and Sec25a-mediated secretome. -other hsa-mir-155 "Leukemia, Lymphocytic, Chronic, B-Cell" 24136167 MicroRNA-155 controls RB phosphorylation in normal and malignant B lymphocytes via the noncanonical TGF-¦Â1/SMAD5 signaling module. -other hsa-mir-320 "Adenocarcinoma, Gastric" 24136787 Strain-specific suppression of microRNA-320 by carcinogenic Helicobacter pylori promotes expression of the antiapoptotic protein Mcl-1. -other hsa-mir-122 Hepatitis C Virus Infection 24141094 "The P body protein LSm1 contributes to stimulation of hepatitis C virus translation, but not replication, by microRNA-122." -other hsa-let-7 Perlman Syndrome 24141620 Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs. -other hsa-mir-196a-1 "Lymphoma, Hodgkin" 24145479 MicroRNA and gene networks in human Hodgkin's lymphoma. -other hsa-mir-9 "Lymphoma, Hodgkin" 24145479 MicroRNA and gene networks in human Hodgkin's lymphoma. -other hsa-mir-203 "Carcinoma, Esophageal" 24154605 Protamine sulfate-nanodiamond hybrid nanoparticles as a vector for MiR-203 restoration in esophageal carcinoma cells. -other hsa-mir-127 Breast Neoplasms 24155205 MicroRNA-127 is downregulated by Tudor-SN protein and contributes to metastasis and proliferation in breast cancer cell line MDA-MB-231. -other hsa-mir-133a Lung Neoplasms 24157646 A high-throughput screen identifies miRNA inhibitors regulating lung cancer cell survival and response to paclitaxel. -other hsa-mir-133b Lung Neoplasms 24157646 A high-throughput screen identifies miRNA inhibitors regulating lung cancer cell survival and response to paclitaxel. -other hsa-mir-346 Lung Neoplasms 24157646 A high-throughput screen identifies miRNA inhibitors regulating lung cancer cell survival and response to paclitaxel. -other hsa-mir-361 Lung Neoplasms 24157646 A high-throughput screen identifies miRNA inhibitors regulating lung cancer cell survival and response to paclitaxel. -other hsa-mir-361 "Carcinoma, Cervical" 24158756 MicroRNA-361-5p facilitates cervical cancer progression through mediation of epithelial-to-mesenchymal transition. -other hsa-mir-139 Breast Neoplasms 24158791 miR-139-5p is a regulator of metastatic pathways in breast cancer. -other hsa-mir-214 Renal Fibrosis 24158985 MicroRNA-214 antagonism protects against renal fibrosis. -other hsa-mir-25 Heart Failure 24161931 Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure. -other hsa-mir-106a Breast Neoplasms 24164962 Downregulation of miR-106b induced breast cancer cell invasion and motility in association with overexpression of matrix metalloproteinase 2. -other hsa-mir-125b Breast Neoplasms 24165569 Taken together our results show a mechanism for EPO/EPOR and ERBB2 co-regulation in breast cancer and confirm the importance of miR-125b in controlling clinically-relevant cancer features. -other hsa-mir-122 Obesity 24165878 Resveratrol and EGCG bind directly and distinctively to miR-33a and miR-122 and modulate divergently their levels in hepatic cells. -other hsa-mir-33 Obesity 24165878 Resveratrol and EGCG bind directly and distinctively to miR-33a and miR-122 and modulate divergently their levels in hepatic cells. -other hsa-mir-375 Neoplasms [unspecific] 24166096 The emerging role of miR-375 in cancer. -other hsa-mir-154 Prostate Neoplasms 24166498 "MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b,miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells." -other hsa-mir-299 Prostate Neoplasms 24166498 "MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b,miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells." -other hsa-mir-376a Prostate Neoplasms 24166498 "MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b,miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells." -other hsa-mir-376c Prostate Neoplasms 24166498 "MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b,miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells." -other hsa-mir-377 Prostate Neoplasms 24166498 "MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b,miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells." -other hsa-mir-381 Prostate Neoplasms 24166498 "MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b,miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells." -other hsa-mir-485 Prostate Neoplasms 24166498 "MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b,miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells." -other hsa-mir-487b Prostate Neoplasms 24166498 "MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b,miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells." -other hsa-mir-654 Prostate Neoplasms 24166498 "MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b,miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells." -other hsa-mir-200b Cholangiocarcinoma 24169343 Our study shows that miR-200b/c has a critical role in the regulation of the tumorigenic and metastatic capacity of cholangiocarcinoma and reveals the probable underlying mechanisms. -other hsa-mir-200c Cholangiocarcinoma 24169343 Our study shows that miR-200b/c has a critical role in the regulation of the tumorigenic and metastatic capacity of cholangiocarcinoma and reveals the probable underlying mechanisms. -other hsa-mir-27a Kidney Neoplasms 24173369 Combination of quercetin and hyperoside has anticancer effects on renal cancer cells through inhibition of oncogenic microRNA-27a. -other hsa-mir-183 Endometriosis 24173391 Downregulation of miR-183 inhibits apoptosis and enhances the invasive potential of endometrial stromal cells in endometriosis. -other hsa-mir-10b "Carcinoma, Nasopharyngeal" 24175854 miR-10b promotes migration and invasion in nasopharyngeal carcinoma cells. -other hsa-mir-125b Chondrosarcoma 24178909 "mTORC 1 inhibitor PRP-1 caused significant upregulation of tumor suppressors, such as miR20a, miR125b, and miR192; and downregulation of onco miRNAs, miR509-3p, miR589, miR490-3p, miR 550 in human chondrosarcoma JJ012 cell line" -other hsa-mir-192 Chondrosarcoma 24178909 "mTORC 1 inhibitor PRP-1 caused significant upregulation of tumor suppressors, such as miR20a, miR125b, and miR192; and downregulation of onco miRNAs, miR509-3p, miR589, miR490-3p, miR 550 in human chondrosarcoma JJ012 cell line" -other hsa-mir-20a Chondrosarcoma 24178909 "mTORC 1 inhibitor PRP-1 caused significant upregulation of tumor suppressors, such as miR20a, miR125b, and miR192; and downregulation of onco miRNAs, miR509-3p, miR589, miR490-3p, miR 550 in human chondrosarcoma JJ012 cell line" -other hsa-mir-490 Chondrosarcoma 24178909 "mTORC 1 inhibitor PRP-1 caused significant upregulation of tumor suppressors, such as miR20a, miR125b, and miR192; and downregulation of onco miRNAs, miR509-3p, miR589, miR490-3p, miR 550 in human chondrosarcoma JJ012 cell line" -other hsa-mir-509 Chondrosarcoma 24178909 "mTORC 1 inhibitor PRP-1 caused significant upregulation of tumor suppressors, such as miR20a, miR125b, and miR192; and downregulation of onco miRNAs, miR509-3p, miR589, miR490-3p, miR 550 in human chondrosarcoma JJ012 cell line" -other hsa-mir-550 Chondrosarcoma 24178909 "mTORC 1 inhibitor PRP-1 caused significant upregulation of tumor suppressors, such as miR20a, miR125b, and miR192; and downregulation of onco miRNAs, miR509-3p, miR589, miR490-3p, miR 550 in human chondrosarcoma JJ012 cell line" -other hsa-mir-589 Chondrosarcoma 24178909 "mTORC 1 inhibitor PRP-1 caused significant upregulation of tumor suppressors, such as miR20a, miR125b, and miR192; and downregulation of onco miRNAs, miR509-3p, miR589, miR490-3p, miR 550 in human chondrosarcoma JJ012 cell line" -other hsa-mir-184 "Carcinoma, Hepatocellular" 24183204 miR-184 functions as an oncogenic regulator in hepatocellular carcinoma (HCC). -other hsa-mir-29b Multiple Myeloma 24189534 miR-29b: a new demethylator in multiple myeloma. -other hsa-mir-206 "Carcinoma, Lung" 24189536 "miR-206 is capable of suppressing a known oncogene, it might be a true tumor suppressor gene and, as such, be deleted, modified, or directly repressed in human tumors." -other hsa-mir-4423 Lung Neoplasms 24191054 A primate-specific microRNA enters the lung cancer landscape. -other hsa-mir-19a Psoriasis 24192448 Our results indicated hair root miR-19a levels are effective as a disease marker. -other hsa-mir-200 Prostate Neoplasms 24193225 Regulation of epithelial plasticity by miR-424 and miR-200 in a new prostate cancer metastasis model. -other hsa-mir-424 Prostate Neoplasms 24193225 Regulation of epithelial plasticity by miR-424 and miR-200 in a new prostate cancer metastasis model. -other hsa-mir-524 Glioma 24194606 Comprehensive analysis of the functional microRNA-mRNA regulatory network identifies miRNA signatures associated with glioma malignant progression. -other hsa-mir-628 Glioma 24194606 Comprehensive analysis of the functional microRNA-mRNA regulatory network identifies miRNA signatures associated with glioma malignant progression. -other hsa-mir-101 Alzheimer Disease 24194717 "we found microRNAs, including miR-20a, miR-17, miR-34a, miR-155, miR-18a, miR-22, miR-26a, miR-101, miR-106b, and miR-125b, that might regulate the expression of nodes in the sub-network." -other hsa-mir-106b Alzheimer Disease 24194717 "we found microRNAs, including miR-20a, miR-17, miR-34a, miR-155, miR-18a, miR-22, miR-26a, miR-101, miR-106b, and miR-125b, that might regulate the expression of nodes in the sub-network." -other hsa-mir-17 Alzheimer Disease 24194717 "we found microRNAs, including miR-20a, miR-17, miR-34a, miR-155, miR-18a, miR-22, miR-26a, miR-101, miR-106b, and miR-125b, that might regulate the expression of nodes in the sub-network." -other hsa-mir-20a Alzheimer Disease 24194717 "we found microRNAs, including miR-20a, miR-17, miR-34a, miR-155, miR-18a, miR-22, miR-26a, miR-101, miR-106b, and miR-125b, that might regulate the expression of nodes in the sub-network." -other hsa-mir-141 Prostate Neoplasms 24195675 Sensitive detection of microRNA in complex biological samples via enzymatic signal amplification using DNA polymerase coupled with nicking endonuclease. -other hsa-mir-221 Breast Neoplasms 24197133 14-3-3¦Æ orchestrates mammary tumor onset and progression via miR-221-mediated cell proliferation. -other hsa-mir-10b "Carcinoma, Lung, Non-Small-Cell" 24198203 "microRNA expression profiles associated with survival, disease progression, and response to gefitinib in completely resected non-small-cell lung cancer with EGFR mutation." -other hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 24198203 "microRNA expression profiles associated with survival, disease progression, and response to gefitinib in completely resected non-small-cell lung cancer with EGFR mutation." -other hsa-mir-30 "Leukemia, Myeloid, Acute" 24199710 Adverse prognostic value of MYBL2 overexpression and association with microRNA-30 family in acute myeloid leukemia patients. -other hsa-mir-17 "Carcinoma, Lung, Non-Small-Cell" 24200043 "This work will provide a framework for constructing miRNA-TF synergistic regulatory networks, function analysis in diseases, and identification of the main regulators and regulatory motifs, which will be useful for understanding the putative regulatory motifs involving miRNAs and TFs, and for predicting new targets for cancer studies." -other hsa-mir-570 "Carcinoma, Lung, Non-Small-Cell" 24200043 "This work will provide a framework for constructing miRNA-TF synergistic regulatory networks, function analysis in diseases, and identification of the main regulators and regulatory motifs, which will be useful for understanding the putative regulatory motifs involving miRNAs and TFs, and for predicting new targets for cancer studies." -other hsa-mir-590 "Carcinoma, Lung, Non-Small-Cell" 24200043 "This work will provide a framework for constructing miRNA-TF synergistic regulatory networks, function analysis in diseases, and identification of the main regulators and regulatory motifs, which will be useful for understanding the putative regulatory motifs involving miRNAs and TFs, and for predicting new targets for cancer studies." -other hsa-mir-888 Prostate Neoplasms 24200968 miR-888 is an expressed prostatic secretions-derived microRNA that promotes prostate cell growth and migration. -other hsa-mir-223 Acute Coronary Syndrome 24202700 Decreased circulating microRNA-223 level predicts high on-treatment platelet reactivity in patients with troponin-negative non-ST elevation acute coronary syndrome. -other hsa-mir-130b Colorectal Carcinoma 24204200 MicroRNA-130b promotes tumor development and is associated with poor prognosis in colorectal cancer. -other hsa-mir-496 Breast Neoplasms 24204564 Methylated DNA binding domain protein 2 (MBD2) coordinately silences gene expression through activation of the microRNA hsa-mir-496 promoter in breast cancer cell line. -other hsa-mir-139 "Squamous Cell Carcinoma, Esophageal" 24204738 Tumor-suppressive function of miR-139-5p in esophageal squamous cell carcinoma. -other hsa-mir-125b "Carcinoma, Adrenocortical" 24205079 "miR-125b, miRNA-200b, miR-122, miRNA-466b, miR-138,vmiRNA-214, miRNA-503 and miRNA27a were down-regulated in response to 17¦Á-E2 treatment." -other hsa-mir-132 "Carcinoma, Adrenocortical" 24205079 "ACTH up-regulated the expression of miRNA-212, miRNA-182, miRNA-183, miRNA-132, and miRNA-96 and down-regulated the levels of miRNA-466b, miRNA-214, miRNA-503, and miRNA-27a." -other hsa-mir-212 "Carcinoma, Adrenocortical" 24205079 "The levels of miR-212,miRNA-183, miRNA-182, miRNA-132, miRNA-370, miRNA-377, and miRNA-96 were up-regulated, whereas miR-125b, miRNA-200b, miR-122, miRNA-466b, miR-138, miRNA-214, miRNA-503 and miRNA27a were down-regulated in response to 17¦Á-E2 treatment." -other hsa-mir-21 Glioblastoma 24205116 MiR-21 in the extracellular vesicles (EVs) of cerebrospinal fluid (CSF): a platform for glioblastoma biomarker development. -other hsa-mir-10b Head And Neck Neoplasms 24209638 The study of microRNA alterations in HNSCC is an essential step to the mechanistic understanding of tumor formation and could lead to the discovery of clinically relevant biomarkers. -other hsa-mir-196a Head And Neck Neoplasms 24209638 The study of microRNA alterations in HNSCC is an essential step to the mechanistic understanding of tumor formation and could lead to the discovery of clinically relevant biomarkers. -other hsa-mir-548a Influenza 24210102 Expression of non-structural-1A binding protein in lung epithelial cells is modulated by miRNA-548an on exposure to influenza A virus. -other hsa-mir-26a Glioblastoma 24211747 MiR-26a enhances the radiosensitivity of glioblastoma multiforme cells through targeting of ataxia-telangiectasia mutated. -other hsa-mir-27a Alzheimer Disease 24212398 Our pilot study highlights hsa-miR-27a-3p as a candidate biomarker for AD and provides the groundwork for further confirmation studies in larger cohorts and in other hospitals. -other hsa-mir-17 Cardiovascular Diseases [unspecific] 24212931 "The miR-17/92 cluster: a comprehensive update on its genomics, genetics,functions and increasingly important and numerous roles in health and disease." -other hsa-mir-18 Cardiovascular Diseases [unspecific] 24212931 "The miR-17/92 cluster: a comprehensive update on its genomics, genetics,functions and increasingly important and numerous roles in health and disease." -other hsa-mir-19a Cardiovascular Diseases [unspecific] 24212931 "The miR-17/92 cluster: a comprehensive update on its genomics, genetics,functions and increasingly important and numerous roles in health and disease." -other hsa-mir-19b-1 Cardiovascular Diseases [unspecific] 24212931 "The miR-17/92 cluster: a comprehensive update on its genomics, genetics,functions and increasingly important and numerous roles in health and disease." -other hsa-mir-20a Cardiovascular Diseases [unspecific] 24212931 "The miR-17/92 cluster: a comprehensive update on its genomics, genetics,functions and increasingly important and numerous roles in health and disease." -other hsa-mir-92-1 Cardiovascular Diseases [unspecific] 24212931 "The miR-17/92 cluster: a comprehensive update on its genomics, genetics,functions and increasingly important and numerous roles in health and disease." -other hsa-mir-185 Depression Disorder 24213247 "The involvement of microRNAs in major depression, suicidal behavior, and related disorders: a focus on miR-185 and miR-491-3p." -other hsa-mir-491 Depression Disorder 24213247 "The involvement of microRNAs in major depression, suicidal behavior, and related disorders: a focus on miR-185 and miR-491-3p." -other hsa-mir-192 "Carcinoma, Colon" 24213572 MicroRNA-192 suppresses liver metastasis of colon cancer. -other hsa-mir-21 Acute Kidney Failure 24214874 MicroRNA-21 in the pathogenesis of acute kidney injury. -other hsa-mir-125a Leukemia 24216483 ASXL1-MT resulted in derepression of homeobox A9 (Hoxa9) and microRNA-125a (miR-125a) expression through inhibition of polycomb repressive complex 2¨Cmediated (PRC2-mediated) methylation of histone H3K27. -other hsa-mir-320a Gastrointestinal Stromal Tumor 24217767 MiR-320a downregulation is associated with imatinib resistance in gastrointestinal stromal tumors. -other hsa-mir-203 "Carcinoma, Esophageal" 24219349 miR-203 inhibits the proliferation and self-renewal of esophageal cancer stem-like cells by suppressing stem renewal factor Bmi-1. -other hsa-mir-130 Neoplasms [unspecific] 24220575 Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif. -other hsa-mir-17 Neoplasms [unspecific] 24220575 Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif. -other hsa-mir-19 Neoplasms [unspecific] 24220575 Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif. -other hsa-mir-210 Neoplasms [unspecific] 24220575 Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif. -other hsa-mir-455 Neoplasms [unspecific] 24220575 Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif. -other hsa-mir-93 Neoplasms [unspecific] 24220575 Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif. -other hsa-mir-367 Ovarian Neoplasms 24220856 "Overexpression of miR-367 in the paclitaxel-sensitive cells [PA1; IC??, 1.69 nM, high miR-367 (2.997), low miR-30a-5p (-0.323)] further increased paclitaxel sensitivity, whereas miR-367 depletion decreased paclitaxel sensitivity." -other hsa-mir-1 Prostate Neoplasms 24222130 "In 22Rv1 cells, all AR isoforms were co-regulated by the cytoprotective factor HSPB1 and the tumor suppressor miR-1. Notably, our data provide evidence that HSPB1 inhibition is able to target expression of long as well as of short AR isoforms." -other hsa-mir-183 "Carcinoma, Hepatocellular" 24222732 Expression and significance of microRNA-183 in hepatocellular carcinoma. -other hsa-mir-196b Gastric Neoplasms 24222951 Co-activation of miR-196b and HOXA10 characterized a poor-prognosis subgroup of patients with gastric cancer. Elucidation of the biologic function of miR-196b and HOXA10 is warranted. -other hsa-mir-135b Multiple Myeloma 24223191 Upregulation of miR-135b is involved in the impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients. -other hsa-mir-4723 Prostate Neoplasms 24223753 MicroRNA-4723 inhibits prostate cancer growth through inactivation of the Abelson family of nonreceptor protein tyrosine kinases. -other hsa-mir-142 Neoplasms [unspecific] 24227773 Two specific miRNAs transferred efficiently between these cells--miR-142 and miR-223--and both were endogenously expressed in macrophages and not in HCCs. -other hsa-mir-429 Colorectal Carcinoma 24237355 miR-429 identified by dynamic transcriptome analysis is a new candidate biomarker for colorectal cancer prognosis. -other hsa-mir-4661 Inflammation 24238336 The bipolar role of miR-4661 in inflammation. -other hsa-mir-103a "Carcinoma, Colon" 24239208 "Our six-miRNA-based classifier is a reliable prognostic and predictive tool for disease recurrence in patients with stage II colon cancer,and might be able to predict which patients benefit from adjuvant chemotherapy.It might facilitate patient counselling and individualise management of patients with this disease." -other hsa-mir-106b "Carcinoma, Colon" 24239208 "Our six-miRNA-based classifier is a reliable prognostic and predictive tool for disease recurrence in patients with stage II colon cancer,and might be able to predict which patients benefit from adjuvant chemotherapy.It might facilitate patient counselling and individualise management of patients with this disease." -other hsa-mir-143 "Carcinoma, Colon" 24239208 "Our six-miRNA-based classifier is a reliable prognostic and predictive tool for disease recurrence in patients with stage II colon cancer,and might be able to predict which patients benefit from adjuvant chemotherapy.It might facilitate patient counselling and individualise management of patients with this disease." -other hsa-mir-20a "Carcinoma, Colon" 24239208 "Our six-miRNA-based classifier is a reliable prognostic and predictive tool for disease recurrence in patients with stage II colon cancer,and might be able to predict which patients benefit from adjuvant chemotherapy.It might facilitate patient counselling and individualise management of patients with this disease." -other hsa-mir-21 "Carcinoma, Colon" 24239208 "Our six-miRNA-based classifier is a reliable prognostic and predictive tool for disease recurrence in patients with stage II colon cancer,and might be able to predict which patients benefit from adjuvant chemotherapy.It might facilitate patient counselling and individualise management of patients with this disease." -other hsa-mir-215 "Carcinoma, Colon" 24239208 "Our six-miRNA-based classifier is a reliable prognostic and predictive tool for disease recurrence in patients with stage II colon cancer,and might be able to predict which patients benefit from adjuvant chemotherapy.It might facilitate patient counselling and individualise management of patients with this disease." -other hsa-mir-30c Adenovirus Infection 24239602 Comparison of RNAi with CCN2-modulating microRNA (miR) vectors expressing miR-30c or miR-133b showed higher efficacy of RNAi. -other hsa-mir-145 Pleural Mesothelioma 24240684 Protumorigenic effects of mir-145 loss in malignant pleural mesothelioma. -other hsa-mir-155 "Carcinoma, Nasopharyngeal" 24241359 MiR-155 up-regulation by LMP1 DNA contributes to increased nasopharyngeal carcinoma cell proliferation and migration. -other hsa-mir-141 "Adenocarcinoma, Pancreatic Ductal" 24242138 Prognostic significance of microRNA-141 expression and its tumor suppressor function in human pancreatic ductal adenocarcinoma. -other hsa-mir-31 Colorectal Carcinoma 24242331 "Association of microRNA-31 with BRAF mutation, colorectal cancer survival and serrated pathway." -other hsa-mir-663 Prostate Neoplasms 24243035 miR-663 induces castration-resistant prostate cancer transformation and predicts clinical recurrence. -other hsa-mir-124 Stroke 24244499 "miR-689, miR-124, and miR-155 were the most strongly associated miRNAs predicted to mediate pro-inflammatory pathways and M1-like activation phenotype." -other hsa-mir-155 Stroke 24244499 "miR-155, the most strongly up-regulated miRNA,regulates the signal transducer and activator of transcription 3 signaling pathway enabling the late phase response to M1-skewing stimulation. " -other hsa-mir-21 Breast Neoplasms 24248894 MicroRNA-21 in breast cancer: diagnostic and prognostic potential. -other hsa-mir-23a Colorectal Carcinoma 24249161 MicroRNA-23a antisense enhances 5-fluorouracil chemosensitivity through APAF-1/caspase-9 apoptotic pathway in colorectal cancer cells. -other hsa-let-7e Breast Neoplasms 24257477 "Our data provide novel evidence of the mechanisms behind miRNA dysregulation in breast cancer. The study contributes to the understanding of how methylation and copy number alterations influence miRNA expression, emphasizing miRNA functionality through redundant encoding, and suggests novel miRNAs important in breast cancer." -other hsa-mir-100 Neoplasms [unspecific] 24258109 Prognostic role of microRNA-100 in various carcinomas: evidence from six studies. -other hsa-mir-148a Osteoarthritis 24269634 "Overexpression of hsa-miR-148a inhibits hypertrophic differentiation and increases the production and deposition of type II collagen by OA chondrocytes, which is accompanied by an increased retention of proteoglycans.Hsa-miR-148a might be a potential disease-modifying compound in OA, as it promotes hyaline cartilage production." -other hsa-mir-23a Myocardial Infarction 24269648 MicroRNA-23a is involved in tumor necrosis factor-¦Á induced apoptosis in mesenchymal stem cells and myocardial infarction. -other hsa-mir-204 Pulmonary Hypertension 24270264 "We also showed that PARP-1 activation accounts for miR-204 downregulation (quantitative reverse transcription polymerase chain reaction) and the subsequent activation of the transcription factors nuclear factor of activated T cells and hypoxia-inducible factor 1-α in PAH-PASMCs, previously shown to be critical for PAH in several models." -other hsa-mir-9 "Leukemia, Myeloid, Acute" 24270738 miR-9 is a tumor suppressor in pediatric AML -other hsa-mir-122 Chronic Hepatitis C 24270780 "Reply to miR-122, IL28B genotype and the response to interferon in chronic hepatitis C virus infection." -other hsa-mir-122 Chronic Hepatitis C 24270782 "miR-122, IL28B genotype and the response to interferon in chronic hepatitis C virus infection." -other hsa-mir-214 Glioma 24277415 Combined aberrant expression of microRNA-214 and UBC9 is an independent unfavorable prognostic factor for patients with gliomas. -other hsa-mir-338 Colorectal Carcinoma 24277750 MicroRNA-338-3p could inhibit colorectal carcinoma cell invasion and migration by inhibiting smoothened expression. -other hsa-mir-503 Chikungunya Virus Infection 24278205 Combined miRNA and mRNA signature identifies key molecular players and pathways involved in chikungunya virus infection in human cells. -other hsa-mir-638 Chikungunya Virus Infection 24278205 Combined miRNA and mRNA signature identifies key molecular players and pathways involved in chikungunya virus infection in human cells. -other hsa-mir-744 Chikungunya Virus Infection 24278205 Combined miRNA and mRNA signature identifies key molecular players and pathways involved in chikungunya virus infection in human cells. -other hsa-mir-132 Epilepsy 24282394 "Targeting miR-34a, miR-132 and miR-184 has been reported to alter seizure-induced neuronal death, whereas targeting miR-134 was neuroprotective, reduced seizure severity during status epilepticus and reduced the later emergence of recurrent spontaneous seizures." -other hsa-mir-184 Epilepsy 24282394 "Targeting miR-34a, miR-132 and miR-184 has been reported to alter seizure-induced neuronal death, whereas targeting miR-134 was neuroprotective, reduced seizure severity during status epilepticus and reduced the later emergence of recurrent spontaneous seizures." -other hsa-mir-323 Alzheimer Disease 24283221 "MicroRNA-323-3p with clinical potential in rheumatoid arthritis, Alzheimer's disease and ectopic pregnancy." -other hsa-mir-155 "Aortic Aneurysm, Abdominal" 24283299 microRNA profiling in patients with abdominal aortic aneurysms: the significance of miR-155. -other hsa-mir-30b "Carcinoma, Lung, Non-Small-Cell" 24286402 Our study identified miR-30b and miR-30c as useful prognostic predictors in NSCLC patients who underwent first line treatment with TKIs. -other hsa-mir-30c "Carcinoma, Lung, Non-Small-Cell" 24286402 Our study identified miR-30b and miR-30c as useful prognostic predictors in NSCLC patients who underwent first line treatment with TKIs. -other hsa-mir-17 Breast Neoplasms 24287487 Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer. -other hsa-mir-20a Breast Neoplasms 24287487 Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer. -other hsa-mir-206 Dermatomyositis 24288551 Correlation between the frequency of Th17 cell and the expression of microRNA-206 in patients with dermatomyositis. -other hsa-mir-206 Melanoma 24289491 MicroRNA-206 induces G1 arrest in melanoma by inhibition of CDK4 and Cyclin D. -other hsa-mir-29 Breast Neoplasms 24289849 The inhibitory role of Mir-29 in growth of breast cancer cells. -other hsa-mir-196a-2 "Leukemia, Lymphoblastic, Acute" 24291415 Hsa-miR-196a2 polymorphism increases the risk of acute lymphoblastic leukemia in Chinese children. -other hsa-mir-146a Systemic Lupus Erythematosus 24292724 STAT1 and miR-146a may be upregulated during inflammation and via proinflammatory cytokines and chemokines in SLE. Prolonged upregulation of STAT1 and miR-146a appears to play an important role in anemia in SLE patients. -other hsa-mir-125b Alzheimer Disease 24293102 "Regulation of neurotropic signaling by the inducible, NF-kB-sensitive miRNA-125b in Alzheimer's disease (AD) and in primary human neuronal-glial (HNG) cells." -other hsa-let-7a Lung Neoplasms 24293999 Targeted delivery of let-7a microRNA encapsulated ephrin-A1 conjugated liposomal nanoparticles inhibit tumor growth in lung cancer. -other hsa-mir-26a "Carcinoma, Hepatocellular" 24296580 Hepatocellular carcinoma: New insight into angiogenesis in hepatocellular carcinoma: involvement of microRNA-26a. -other hsa-mir-205 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 24297308 MicroRNA-205 suppresses proliferation and promotes apoptosis in laryngeal squamous cell carcinoma. -other hsa-let-7b "Carcinoma, Hepatocellular" 24297460 Bioinformatic analysis of the membrane cofactor protein CD46 and microRNA expression in hepatocellular carcinoma. -other hsa-mir-17 "Carcinoma, Hepatocellular" 24297460 Bioinformatic analysis of the membrane cofactor protein CD46 and microRNA expression in hepatocellular carcinoma. -other hsa-mir-483 Neoplasms [unspecific] 24298054 The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis. -other hsa-mir-218 Lung Fibrosis 24298938 Andrographolide antagonizes cigarette smoke extract-induced inflammatory response and oxidative stress in human alveolar epithelial A549 cells through induction of microRNA-218. -other hsa-mir-146b Prostate Neoplasms 24301753 "After Gene Set Functional Similarity analysis, we obtained 20 abnormal PC-related candidate miRNAs, including hsa-miR-26a, hsa-miR-152, hsa-miR-19a, hsa-miR-30c, hsa-miR-19b, and hsa-miR-146b-5p, among others." -other hsa-mir-30c Prostate Neoplasms 24301753 "After Gene Set Functional Similarity analysis, we obtained 20 abnormal PC-related candidate miRNAs, including hsa-miR-26a, hsa-miR-152, hsa-miR-19a, hsa-miR-30c, hsa-miR-19b, and hsa-miR-146b-5p, among others." -other hsa-mir-381 Neoplasms [unspecific] 24303078 Changes in the expression of miR-381 and miR-495 are inversely associated with the expression of the MDR1 gene and development of multi-drug resistance. -other hsa-mir-495 Neoplasms [unspecific] 24303078 Changes in the expression of miR-381 and miR-495 are inversely associated with the expression of the MDR1 gene and development of multi-drug resistance. -other hsa-mir-18b Melanoma 24303553 Role of miR-18b/MDM2/p53 circuitry in melanoma progression. -other hsa-mir-155 Immune System Disease [unspecific] 24303979 Role of miR-155 in the regulation of lymphocyte immune function and disease. -other hsa-mir-96 Neurodegenerative Diseases [unspecific] 24304186 Widespread microRNA dysregulation in multiple system atrophy - disease-related alteration in miR-96. -other hsa-mir-210 "Carcinoma, Lung, Non-Small-Cell" 24305009 "We show that miR-210 in stromal cells, and co-expressed in cancer cells and stromal cells mediates an independent prognostic impact. It is a candidate marker for prognostic stratification in NSCLC." -other hsa-mir-328 Glioma 24305703 MiR-328 promotes glioma cell invasion via SFRP1-dependent Wnt-signaling activation. -other hsa-mir-17 Pediatric Glioma 24305714 Our results suggest that microRNA profiling represents a tool to distinguishing pediatric from adult HGG and that miR-17-92 cluster sustains pHGG. -other hsa-mir-18 Pediatric Glioma 24305714 Our results suggest that microRNA profiling represents a tool to distinguishing pediatric from adult HGG and that miR-17-92 cluster sustains pHGG. -other hsa-mir-19a Pediatric Glioma 24305714 Our results suggest that microRNA profiling represents a tool to distinguishing pediatric from adult HGG and that miR-17-92 cluster sustains pHGG. -other hsa-mir-19b-1 Pediatric Glioma 24305714 Our results suggest that microRNA profiling represents a tool to distinguishing pediatric from adult HGG and that miR-17-92 cluster sustains pHGG. -other hsa-mir-20a Pediatric Glioma 24305714 Our results suggest that microRNA profiling represents a tool to distinguishing pediatric from adult HGG and that miR-17-92 cluster sustains pHGG. -other hsa-mir-92-1 Pediatric Glioma 24305714 Our results suggest that microRNA profiling represents a tool to distinguishing pediatric from adult HGG and that miR-17-92 cluster sustains pHGG. -other hsa-mir-141 Osteosarcoma 24307282 Tumor-suppressing effects of miR-141 in human osteosarcoma. -other hsa-mir-1 Glioblastoma 24310399 Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1. -other hsa-mir-30e Gastrointestinal Neoplasms 24312366 Identification of miR-30e* regulation of Bmi1 expression mediated by tumor-associated macrophages in gastrointestinal cancer. -other hsa-mir-149 Gastrointestinal Neoplasms 24312386 "The present meta-analysis indicates that miR-499 may be associated with the risk to colorectal cancer. MiR-149 may confer a marginally increased risk of susceptibility to gastrointestinal cancer, especially for Asians." -other hsa-mir-499 Gastrointestinal Neoplasms 24312386 "The present meta-analysis indicates that miR-499 may be associated with the risk to colorectal cancer. MiR-149 may confer a marginally increased risk of susceptibility to gastrointestinal cancer, especially for Asians." -other hsa-mir-153 Fetal Alcohol Spectrum Disorder 24313161 Dysregulation of microRNA expression and function contributes to the etiology of fetal alcohol spectrum disorders. -other hsa-mir-21 Fetal Alcohol Spectrum Disorder 24313161 Dysregulation of microRNA expression and function contributes to the etiology of fetal alcohol spectrum disorders. -other hsa-mir-335 Fetal Alcohol Spectrum Disorder 24313161 Dysregulation of microRNA expression and function contributes to the etiology of fetal alcohol spectrum disorders. -other hsa-mir-9 Fetal Alcohol Spectrum Disorder 24313161 Dysregulation of microRNA expression and function contributes to the etiology of fetal alcohol spectrum disorders. -other hsa-mir-34 Asthma 24313771 Subtypes of asthma defined by epithelial cell expression of messenger RNA and microRNA. -other hsa-mir-449 Asthma 24313771 Subtypes of asthma defined by epithelial cell expression of messenger RNA and microRNA. -other hsa-mir-146a "Carcinoma, Hepatocellular" 24314246 "Drug-resistant HCC cells have abnormal expressed miRNAs, which may be explored to further investigate the association of miRNA expressions with multidrugs resistance in HCC." -other hsa-mir-146b "Carcinoma, Hepatocellular" 24314246 "Drug-resistant HCC cells have abnormal expressed miRNAs, which may be explored to further investigate the association of miRNA expressions with multidrugs resistance in HCC." -other hsa-mir-15a "Carcinoma, Hepatocellular" 24314246 "Drug-resistant HCC cells have abnormal expressed miRNAs, which may be explored to further investigate the association of miRNA expressions with multidrugs resistance in HCC." -other hsa-mir-16 "Carcinoma, Hepatocellular" 24314246 "Drug-resistant HCC cells have abnormal expressed miRNAs, which may be explored to further investigate the association of miRNA expressions with multidrugs resistance in HCC." -other hsa-mir-181d "Carcinoma, Hepatocellular" 24314246 "Drug-resistant HCC cells have abnormal expressed miRNAs, which may be explored to further investigate the association of miRNA expressions with multidrugs resistance in HCC." -other hsa-mir-194 "Carcinoma, Hepatocellular" 24314246 "Drug-resistant HCC cells have abnormal expressed miRNAs, which may be explored to further investigate the association of miRNA expressions with multidrugs resistance in HCC." -other hsa-mir-27b "Carcinoma, Hepatocellular" 24314246 "Drug-resistant HCC cells have abnormal expressed miRNAs, which may be explored to further investigate the association of miRNA expressions with multidrugs resistance in HCC." -other hsa-mir-30b "Carcinoma, Hepatocellular" 24314246 "Drug-resistant HCC cells have abnormal expressed miRNAs, which may be explored to further investigate the association of miRNA expressions with multidrugs resistance in HCC." -other hsa-mir-205 Human Papilloma Virus Infection 24314651 miR-24 and miR-205 expression is dependent on HPV onco-protein expression in keratinocytes. -other hsa-mir-24 Human Papilloma Virus Infection 24314651 miR-24 and miR-205 expression is dependent on HPV onco-protein expression in keratinocytes. -other hsa-mir-122 Hepatitis B Virus Infection 24314655 microRNA expression in hepatitis B virus infected primary treeshrew hepatocytes and the independence of intracellular miR-122 level for de novo HBV infection in culture. -other hsa-mir-221 Gastric Neoplasms 24317477 Relapse-associated microRNA in gastric cancer patients after S-1 adjuvant chemotherapy. -other hsa-mir-422a Gastric Neoplasms 24317477 Relapse-associated microRNA in gastric cancer patients after S-1 adjuvant chemotherapy. -other hsa-mir-4732 Gastric Neoplasms 24317477 Relapse-associated microRNA in gastric cancer patients after S-1 adjuvant chemotherapy. -other hsa-mir-4758 Gastric Neoplasms 24317477 Relapse-associated microRNA in gastric cancer patients after S-1 adjuvant chemotherapy. -other hsa-mir-92b Gastric Neoplasms 24317477 Relapse-associated microRNA in gastric cancer patients after S-1 adjuvant chemotherapy. -other hsa-mir-127 "Adenocarcinoma, Lung" 24317514 Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinoma. -other hsa-mir-376a "Adenocarcinoma, Lung" 24317514 Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinoma. -other hsa-mir-26a Pulmonary Hypertension 24328779 miR-26a linked to pulmonary hypertension by global assessment of circulating extracellular microRNAs. -other hsa-mir-193a "Carcinoma, Hepatocellular" 24330766 Effects of miR-193a and sorafenib on hepatocellular carcinoma cells. -other hsa-mir-155 Encephalomyelitis 24332164 MicroRNA-155 modulates Th1 and Th17 cell differentiation and is associated with multiple sclerosis and experimental autoimmune encephalomyelitis. -other hsa-mir-92a Pancreatic Neoplasms 24332650 miR-92a/DUSP10/JNK signalling axis promotes human pancreatic cancer cells proliferation. -other hsa-mir-302 "Carcinoma, Endometrial" 24333727 MicroRNA miR-302 inhibits the tumorigenicity of endometrial cancer cells by suppression of Cyclin D1 and CDK1. -other hsa-mir-29 Fuchs Endothelial Dystrophy 24334445 Decreased endothelial expression of miR-29 family members may be associated with increased subendothelial extracellular matrix accumulation in FECD. -other hsa-mir-491 "Squamous Cell Carcinoma, Oral" 24335959 miRNA-491-5p and GIT1 serve as modulators and biomarkers for oral squamous cell carcinoma invasion and metastasis. -other hsa-mir-148a Prostate Neoplasms 24337069 Comparative microRNA profiling of prostate carcinomas with increasing tumor stage by deep sequencing. -other hsa-mir-200b Prostate Neoplasms 24337069 Comparative microRNA profiling of prostate carcinomas with increasing tumor stage by deep sequencing. -other hsa-mir-20a Prostate Neoplasms 24337069 Comparative microRNA profiling of prostate carcinomas with increasing tumor stage by deep sequencing. -other hsa-mir-375 Prostate Neoplasms 24337069 Comparative microRNA profiling of prostate carcinomas with increasing tumor stage by deep sequencing. -other hsa-mir-7 "Carcinoma, Hepatocellular" 24339204 Downregulation of miR-7 upregulates Cullin 5 (CUL5) to facilitate G1/S transition in human hepatocellular carcinoma cells. -other hsa-mir-608 "Adenocarcinoma, Lung" 24339958 Bcl-xL silencing induces alterations in hsa-miR-608 expression and subsequent cell death in A549 and SK-LU1 human lung adenocarcinoma cells. -other hsa-mir-29 Bladder Outlet Obstruction 24340017 Mir-29 repression in bladder outlet obstruction contributes to matrix remodeling and altered stiffness. -other hsa-mir-323b Hepatitis B Virus Infection 24341744 Association of a microRNA-323b polymorphism with the persistence of hepatitis B virus infection by the enhancement of viral replication. -other hsa-mir-26a "Squamous Cell Carcinoma, Tongue" 24343426 "Expression, regulation and roles of miR-26a and MEG3 in tongue squamous cell carcinoma." -other hsa-mir-155 Lymphoma 24345320 Primary vitreoretinal B-cell lymphoma and uveitis might be characterized by distinct microRNA signatures. Quantification of ocular microRNA-155 might be helpful in the differential diagnosis of these 2 diseases. -other hsa-mir-30d Thyroid Neoplasms 24345332 Regulation of autophagy by miR-30d impacts sensitivity of anaplastic thyroid carcinoma to cisplatin. -other hsa-mir-712 Atherosclerosis 24346612 The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis. -other hsa-mir-29 "Diabetes Mellitus, Type 2" 24349318 "Urinary miR-29a correlated with albuminuria while urinary miR-29b correlated with carotid intima-media thickness (cIMT) in patients with type 2 diabetes. Therefore, they may have the potential to serve as alternative biomarker for diabetic nephropathy and atherosclerosis in type 2 diabetes." -other hsa-mir-19a "Leukemia, Myeloid, Acute" 24349422 HDAC inhibitors repress BARD1 isoform expression in acute myeloid leukemia cells via activation of miR-19a and/or b. -other hsa-mir-19b "Leukemia, Myeloid, Acute" 24349422 HDAC inhibitors repress BARD1 isoform expression in acute myeloid leukemia cells via activation of miR-19a and/or b. -other hsa-mir-126 Cardiovascular Diseases [unspecific] 24349482 miR-126 expression was depressed in the process of EPC EndMT. -other hsa-mir-494 Diabetes Mellitus 24349514 "MicroRNA-494, upregulated by tumor necrosis factor-¦Á, desensitizes insulin effect in C2C12 muscle cells." -other hsa-mir-217 Leukemia 24350829 "Downregulation of miR-217 correlates with resistance of Ph(+) leukemia cells to ABL tyrosine kinase inhibitors. miR-#-5p,miR-#-3p" -other hsa-mir-200 Gastric Neoplasms 24352645 We have uncovered a key microRNA regulatory network that defines the mesenchymal gastric cancer subtype significantly associated with poor overall survival in gastric cancer -other hsa-mir-185 Gastric Neoplasms 24352663 miR-185 is an independent prognosis factor and suppresses tumor metastasis in gastric cancer. -other hsa-mir-148b Alzheimer Disease 24352679 Constructing and characterizing a bioactive small molecule and microRNA association network for Alzheimer's disease. -other hsa-mir-15a Alzheimer Disease 24352679 Constructing and characterizing a bioactive small molecule and microRNA association network for Alzheimer's disease. -other hsa-mir-122 Liver Diseases [unspecific] 24354366 Roadmap of miR-122-related clinical application from bench to bedside. -other hsa-mir-106b "Carcinoma, Hepatocellular" 24358224 Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma cells. -other hsa-mir-17 "Carcinoma, Hepatocellular" 24358224 Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma cells. -other hsa-mir-18 "Carcinoma, Hepatocellular" 24358224 Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma cells. -other hsa-mir-191 "Carcinoma, Hepatocellular" 24358224 Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma cells. -other hsa-mir-19a "Carcinoma, Hepatocellular" 24358224 Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma cells. -other hsa-mir-19b-1 "Carcinoma, Hepatocellular" 24358224 Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma cells. -other hsa-mir-20a "Carcinoma, Hepatocellular" 24358224 Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma cells. -other hsa-mir-21 "Carcinoma, Hepatocellular" 24358224 Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma cells. -other hsa-mir-92-1 "Carcinoma, Hepatocellular" 24358224 Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma cells. -other hsa-mir-142 Systemic Mastocytosis 24361879 miR-142-3p enhances Fc¦ÅRI-mediated degranulation in mast cells. -other hsa-mir-2909 Viral Infectious Disease 24361962 Arsenic programmes cellular genomic-immunity through miR-2909 RNomics. -other hsa-mir-499 Myocardial Infarction 24363996 Treatment with cLA and nitrite significantly induced levels of miRNA-499 compared to untreated MI mice. -other hsa-mir-126 Neoplasms [unspecific] 24368110 miR-126 in human cancers: clinical roles and current perspectives. -other hsa-mir-144 "Carcinoma, Esophageal" 24369245 miRNA-144 in the saliva is a genetic marker for early diagnosis of esophageal cancer -other hsa-mir-205 Prostate Neoplasms 24370341 miR-205 impairs the autophagic flux and enhances cisplatin cytotoxicity in castration-resistant prostate cancer cells. -other hsa-mir-21 Diabetic Nephropathy 24370587 Tongxinluo ameliorates renal structure and function by regulating miR-21-induced epithelial-to-mesenchymal transition in diabetic nephropathy. -other hsa-mir-193b "Squamous Cell Carcinoma, Skin or Unspecific" 24374827 miR-193b/365a cluster controls progression of epidermal squamous cell carcinoma. -other hsa-mir-365a "Squamous Cell Carcinoma, Skin or Unspecific" 24374827 miR-193b/365a cluster controls progression of epidermal squamous cell carcinoma. -other hsa-mir-497 Colorectal Carcinoma 24375248 MicroRNA-497 and bufalin act synergistically to inhibit colorectal cancer metastasis. -other hsa-mir-200 Colorectal Carcinoma 24376848 The role of microRNA-200 in progression of human colorectal and breast cancer. -other hsa-mir-126 "Carcinoma, Cervical" 24377569 miR-126 Suppresses the proliferation of cervical cancer cells and alters cell sensitivity to the chemotherapeutic drug bleomycin -other hsa-mir-27b "Leukemia, Myeloid" 24378438 (6)-Gingerolinduced myeloid leukemia cell death is initiated by reactive oxygen species and activation of miR-27b expression. -other hsa-mir-92a "Diabetes Mellitus, Type 2" 24379347 "The updated subnetwork predicted that miR-126/-193b/-92a control CCL2 production by several TFs, including v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) (ETS1), MYC-associated factor X (MAX), and specificity protein 12 (SP1)." -other hsa-mir-155 Hepatitis C Virus Infection 24383923 MicroRNA-155 controls Toll-like receptor 3- and hepatitis C virus-induced immune responses in the liver. -other hsa-mir-130a Hepatitis C Virus Infection 24383925 MicroRNA-130a inhibits HCV replication by restoring the innate immune response. -other hsa-mir-122 Liver Neoplasms 24386085 ADAR2-mediated editing of miR-214 and miR-122 precursor and antisense RNA transcripts in liver cancers. -other hsa-mir-214 Liver Neoplasms 24386085 ADAR2-mediated editing of miR-214 and miR-122 precursor and antisense RNA transcripts in liver cancers. -other hsa-mir-17 Cardiovascular Diseases [unspecific] 24386440 "These findings revealed the role of miRNAs in h-ERG trafficking, which may contribute to the cardiac electrical disturbances associated with oxidative stress." -other hsa-mir-200 "Lymphoma, Large B-Cell, Diffuse" 24390222 Inhibition of ZEB1 by miR-200 characterizes Helicobacter pylori-positive gastric diffuse large B-cell lymphoma with a less aggressive behavior. -other hsa-mir-206 Lung Neoplasms 24390363 Quantitative proteomics and protein network analysis of A549 lung cancer cells affected by miR-206. -other hsa-mir-9-1 Methylmalonic Acidemia 24390963 A Primary Study on Down-Regulated miR-9-1 and Its Biological Significances in Methylmalonic Acidemia. -other hsa-mir-21 Wound Inflammation 24391209 Engulfment of apoptotic cells by macrophages: a role of microRNA-21 in the resolution of wound inflammation. -other hsa-mir-23b Skin Neoplasms 24391759 UVA and UVB irradiation differentially regulate microRNA expression in human primary keratinocytes. -other hsa-mir-155 Human Immunodeficiency Virus Infection 24391808 Cocaine enhances HIV-1 infectivity in monocyte derived dendritic cells by suppressing microRNA-155. -other hsa-mir-200b Prostate Neoplasms 24391862 "miR-200b inhibits prostate cancer EMT, growth and metastasis." -other hsa-mir-1 Prostate Neoplasms 24391925 Coordinate microRNA-mediated regulation of protein complexes in prostate cancer. -other hsa-mir-16 Prostate Neoplasms 24391925 Coordinate microRNA-mediated regulation of protein complexes in prostate cancer. -other hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 24392455 Hsa-miR-15a and Hsa-miR-16-1 expression is not related to proliferation centers abundance and other prognostic factors in chronic lymphocytic leukemia. -other hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 24392455 Hsa-miR-15a and Hsa-miR-16-1 expression is not related to proliferation centers abundance and other prognostic factors in chronic lymphocytic leukemia. -other hsa-let-7 Ovarian Neoplasms 24393345 Ovarian cancer cell invasiveness is associated with discordant exosomal sequestration of Let-7 miRNA and miR-200. -other hsa-mir-200 Ovarian Neoplasms 24393345 Ovarian cancer cell invasiveness is associated with discordant exosomal sequestration of Let-7 miRNA and miR-200. -other hsa-mir-210 Breast Neoplasms 24395300 Emerging roles of miR-210 and other non-coding RNAs in the hypoxic response. -other hsa-mir-210 Pancreatic Neoplasms 24395300 Emerging roles of miR-210 and other non-coding RNAs in the hypoxic response. -other hsa-mir-15a Diabetic Vasculopathy 24397367 "Vitamin D manipulates miR-181c, miR-20b and miR-15a in human umbilical vein endothelial cells exposed to a diabetic-like environment." -other hsa-mir-181c Diabetic Vasculopathy 24397367 "Vitamin D manipulates miR-181c, miR-20b and miR-15a in human umbilical vein endothelial cells exposed to a diabetic-like environment." -other hsa-mir-20b Diabetic Vasculopathy 24397367 "Vitamin D manipulates miR-181c, miR-20b and miR-15a in human umbilical vein endothelial cells exposed to a diabetic-like environment." -other hsa-mir-503 Lung Neoplasms 24398307 "MiR-503 was able to reverse the cisplatin resistance of A549/DDP.MiR-503 processed this kind of effect by inhibiting the drug efflux,downregulating the expression of drug-resistant related proteins and promoting cell apoptosis." -other hsa-mir-17 Breast Neoplasms 24398324 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets. -other hsa-mir-182 Breast Neoplasms 24398324 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets. -other hsa-mir-19a Breast Neoplasms 24398324 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets. -other hsa-mir-200b Breast Neoplasms 24398324 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets. -other hsa-mir-22 Breast Neoplasms 24398324 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets. -other hsa-mir-24 Breast Neoplasms 24398324 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets. -other hsa-mir-25 Breast Neoplasms 24398324 Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets. -other hsa-mir-602 "Carcinoma, Hepatocellular, HBV-Related" 24398562 Arctiin induces an UVB protective effect in human dermal fibroblast cells through microRNA expression changes. -other hsa-mir-194 "Adenocarcinoma, Pancreatic Ductal" 24398877 Upregulation of miR-194 contributes to tumor growth and progression in pancreatic ductal adenocarcinoma. -other hsa-mir-340 Pediatric Osteosarcoma 24398981 Combined microRNA-340 and ROCK1 mRNA profiling predicts tumor progression and prognosis in pediatric osteosarcoma. -other hsa-mir-223 Breast Neoplasms 24400121 miR-223 is a coordinator of breast cancer progression as revealed by bioinformatics predictions. -other hsa-let-7c "Carcinoma, Lung, Non-Small-Cell" 24400442 Modulation of let-7c altered the sensitivity of A549/DDP cells to DDP through regulating DDP-induced apopotis. -other hsa-mir-451 Rheumatoid Arthritis 24401767 Comprehensive analysis of miRNA expression in T-cell subsets of rheumatoid arthritis patients reveals defined signatures of naive and memory Tregs. -other hsa-mir-511 "Adenocarcinoma, Lung" 24402374 miR-511 induces the apoptosis of radioresistant lung adenocarcinoma cells by triggering BAX. -other hsa-mir-125b "Carcinoma, Cervical" 24402874 MicroRNAs as biomarkers of cervical cancer development: a literature review on miR-125b and miR-34a. -other hsa-mir-34a "Carcinoma, Cervical" 24402874 MicroRNAs as biomarkers of cervical cancer development: a literature review on miR-125b and miR-34a. -other hsa-mir-30a "Carcinoma, Renal Cell, Clear-Cell" 24402943 miR-30c-2-3p and miR-30a-3p: new pieces of the jigsaw puzzle in HIF2¦Á regulation. -other hsa-mir-30c-2 "Carcinoma, Renal Cell, Clear-Cell" 24402943 miR-30c-2-3p and miR-30a-3p: new pieces of the jigsaw puzzle in HIF2¦Á regulation. -other hsa-mir-375 "Carcinoma, Lung, Non-Small-Cell" 24404590 Decreased circulating miR-375: a potential biomarker for patients with non-small-cell lung cancer. -other hsa-mir-146a "Carcinoma, Cervical" 24406730 Increased exosomal microRNA-21 and microRNA-146a levels in the cervicovaginal lavage specimens of patients with cervical cancer. -other hsa-mir-21 "Carcinoma, Cervical" 24406730 Increased exosomal microRNA-21 and microRNA-146a levels in the cervicovaginal lavage specimens of patients with cervical cancer. -other hsa-mir-378a Colorectal Carcinoma 24412052 Clinical and biological significance of miR-378a-3p and miR-378a-5p in colorectal cancer. -other hsa-mir-23a "Carcinoma, Hepatocellular" 24417970 Correlation between miR-23a and onset of hepatocellular carcinoma. -other hsa-mir-16 Glioblastoma 24418124 MicroRNA-16 inhibits glioma cell growth and invasion through suppression of BCL2 and the nuclear factor-¦ÊB1/MMP9 signaling pathway. -other hsa-mir-337 Gastric Neoplasms 24422944 "These findings indicate that hsa-miR-337-3p plays a role in the reduction of gastric cancer cell invasion capacity, and further studies on the mechanism of hsa-miR-337-3p in gastric cancer metastasis are warranted." -other hsa-mir-107 Childhood Obesity 24423308 "Childhood obesity is associated with changes in immune cell frequency, inflammatory environment, and regulation of metabolic gene expression.These changes have been causally linked to the onset of metabolic disease in adulthood and suggest the future trajectory of obese children to the development of type 2 diabetes mellitus and premature cardiovascular disease." -other hsa-mir-33 Childhood Obesity 24423308 "Childhood obesity is associated with changes in immune cell frequency, inflammatory environment, and regulation of metabolic gene expression.These changes have been causally linked to the onset of metabolic disease in adulthood and suggest the future trajectory of obese children to the development of type 2 diabetes mellitus and premature cardiovascular disease." -other hsa-mir-20a Alzheimer Disease 24423585 "The results of microarray analysis showed that miR-329, miR-193b, miR-20a, miR-296, and miR-130b were all upregulated in H2O2-induced primary hippocampal neurons and different strains of senescence accelerated mice." -other hsa-mir-29b Uterine Leiomyoma 24424054 Down-regulation of miR-29b is essential for pathogenesis of uterine leiomyoma. -other hsa-mir-141 "Squamous Cell Carcinoma, Head and Neck" 24424572 Role of miR-200c/miR-141 in the regulation of epithelial-mesenchymal transition and migration in head and neck squamous cell carcinoma. -other hsa-mir-200c "Squamous Cell Carcinoma, Head and Neck" 24424572 Role of miR-200c/miR-141 in the regulation of epithelial-mesenchymal transition and migration in head and neck squamous cell carcinoma. -other hsa-mir-146a "Carcinoma, Nasopharyngeal" 24430575 Association of miR-146a gene polymorphism with risk of nasopharyngeal carcinoma in the central-southern Chinese population. -other hsa-mir-93 Inflammation 24433094 Expression of microRNA-93 and Interleukin-8 during Pseudomonas aeruginosa-mediated induction of proinflammatory responses. -other hsa-mir-215 Hepatitis B Virus Infection 24434140 Hepatitis B virus X protein mutant HBx¦¤127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT. -other hsa-mir-125b Human Immunodeficiency Virus Infection 24434277 Methamphetamine inhibits HIV-1 replication in CD4+ T cells by modulating anti-HIV-1 miRNA expression. -other hsa-mir-150 Human Immunodeficiency Virus Infection 24434277 Methamphetamine inhibits HIV-1 replication in CD4+ T cells by modulating anti-HIV-1 miRNA expression. -other hsa-mir-28 Human Immunodeficiency Virus Infection 24434277 Methamphetamine inhibits HIV-1 replication in CD4+ T cells by modulating anti-HIV-1 miRNA expression. -other hsa-mir-21 Gastric Neoplasms 24434352 the effect of celastrol on apoptosis was due to miR-21 inhibiting the PI3K/Akt-dependent NF-¦ÊB pathway. -other hsa-mir-205 Lung Neoplasms 24434435 We have demonstrated for the first time a new molecular pathway that connects TMPRSS4 and integrin ¦Á5 through miR-205 to regulate cancer cell invasion and metastasis. -other hsa-mir-34a Cardiovascular Diseases [unspecific] 24438466 MicroRNA-34a: role in cancer and cardiovascular disease. -other hsa-mir-34a Neoplasms [unspecific] 24438466 MicroRNA-34a: role in cancer and cardiovascular disease. -other hsa-mir-342 Alzheimer Disease 24440716 miR-342-5p decreases ankyrin G levels in Alzheimer's disease transgenic mouse models. -other hsa-mir-146a Meningitis 24442429 Induction of endotoxin tolerance by pathogenic Neisseria is correlated with the inflammatory potential of lipooligosaccharides and regulated by microRNA-146a. -other hsa-mir-106a Pancreatic Neoplasms 24444603 Upregulated miR-106a plays an oncogenic role in pancreatic cancer. -other hsa-mir-34a "Carcinoma, Lung, Non-Small-Cell" 24444609 Restoration of p53/miR-34a regulatory axis decreases survival advantage and ensures Bax-dependent apoptosis of non-small cell lung carcinoma cells. -other hsa-mir-200 Ovarian Neoplasms 24447705 Sequence variation among members of the miR-200 microRNA family is correlated with variation in the ability to induce hallmarks of mesenchymal-epithelial transition in ovarian cancer cells. -other hsa-mir-21 Cardiovascular Diseases [unspecific] 24447911 "Ang II induced miR-21 expression in primary mouse cardiac fibroblasts (CFs) via ERK-dependent AP-1 and STAT3 activation, and while a miR-21 inhibitor reversed Ang II-induced RECK suppression, a miR-21 mimic inhibited both RECK expression and Ang II-induced CF migration." -other hsa-mir-30c Prostate Neoplasms 24452717 MicroRNA-30c serves as an independent biochemical recurrence predictor and potential tumor suppressor for prostate cancer. -other hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 24452750 Expression of microRNA-21 in non-small cell lung cancer tissue increases with disease progression and is likely caused by growth conditional changes during malignant transformation. -other hsa-mir-147 Neoplasms [unspecific] 24454732 MicroRNA-147 induces a mesenchymal-to-epithelial transition (MET) and reverses EGFR inhibitor resistance. -other hsa-let-7 Osteosarcoma 24457375 the involvement of let-7 family miRNA in regulation of the cell proliferation as well as epithelial-mesenchymal transition of OS. -other hsa-mir-888 Prostate Neoplasms 24457835 miR-888 is an expressed prostatic secretions-derived microRNA that promotes prostate cell growth and migration. -other hsa-mir-10b Breast Neoplasms 24457988 Critical role of miR-10b in transforming growth factor-¦Â1-induced epithelial-mesenchymal transition in breast cancer. -other hsa-mir-520d "Carcinoma, Hepatocellular" 24458129 Hsa-miR-520d induces hepatoma cells to form normal liver tissues via a stemness-mediated process. -other hsa-mir-150 Atrial Fibrillation 24462065 Relation of reduced expression of MiR-150 in platelets to atrial fibrillation in patients with chronic systolic heart failure. -other hsa-mir-150 Heart Failure 24462065 Relation of reduced expression of MiR-150 in platelets to atrial fibrillation in patients with chronic systolic heart failure. -other hsa-mir-133a Colorectal Carcinoma 24464560 "DSS-induced chronic inflammation downregulates miR-133a and miR-143/145, which is reportedly associated with human colorectal cancer and PI3K/Akt activation." -other hsa-mir-300 Glioma 24464870 mir-300 promotes self-renewal and inhibits the differentiation of glioma stem-like cells. -other hsa-mir-206 Heart Failure 24465270 Provide a complex overview of microRNA-206. -other hsa-mir-137 Glioblastoma 24465609 Genomic analyses reveal broad impact of miR-137 on genes associated with malignant transformation and neuronal differentiation in glioblastoma cells. -other hsa-mir-26a Ovarian Neoplasms 24466274 MiR-26a promotes ovarian cancer proliferation and tumorigenesis. -other hsa-mir-21 IgA Nephropathy 24468088 Inhibition of miRNA-21 prevents fibrogenic activation in podocytes and tubular cells in IgA nephropathy. -other hsa-mir-1 Arrhythmia 24468403 Down-regulation of miR-1 could relieve arrhythmogenesis by the anti-miR-1 antisense oligonucleotides (AMO-1). -other hsa-mir-200c Lung Neoplasms 24468793 "Recent studies suggest that epithelial-mesenchymal transition (EMT) is the most important contributor to cancer metastasis. Induction of this complex process requires endogenously produced microRNAs; specifically, downregulation of the miRNA-200c causes an induction of EMT." -other hsa-mir-155 Cardiovascular Diseases [unspecific] 24475727 The role of miRNA-155 in cardiovascular diseases -other hsa-mir-182 Uterine Leiomyoma 24476133 "We observed that administration of MK-2206, an allosteric AKT inhibitor, increased levels of reactive oxygen species, up-regulated the microRNA miR-182 and several senescence-associated genes (including p16, p53, p21, and β-galactosidase), and drove leiomyoma cells into stress-induced premature senescence (SIPS)." -other hsa-mir-27a Pancreatic Neoplasms 24479798 Our findings demonstrated that genistein plays a tumor suppressor role in part through inhibition of miR-27a in pancreatic cancer cells. -other hsa-mir-92a Lipid Metabolism Disorder 24481837 MiR-92a: at the heart of lipid-driven endothelial dysfunction. -other hsa-mir-128 "Carcinoma, Breast, Triple Negative" 24485087 "This study provides evidence of posttranscriptional downregulation of Smurf2 in triple-negative breast cancers, and demonstrates that the loss of RB function is involved in microRNA-mediated interference with Smurf2 translation.The new link from RB inactivation to Smurf2 downregulation is likely to play a role in malignant phenotypes of triple-negative breast cancer cells." -other hsa-mir-15a "Carcinoma, Breast, Triple Negative" 24485087 "This study provides evidence of posttranscriptional downregulation of Smurf2 in triple-negative breast cancers, and demonstrates that the loss of RB function is involved in microRNA-mediated interference with Smurf2 translation.The new link from RB inactivation to Smurf2 downregulation is likely to play a role in malignant phenotypes of triple-negative breast cancer cells." -other hsa-mir-15b "Carcinoma, Breast, Triple Negative" 24485087 "This study provides evidence of posttranscriptional downregulation of Smurf2 in triple-negative breast cancers, and demonstrates that the loss of RB function is involved in microRNA-mediated interference with Smurf2 translation.The new link from RB inactivation to Smurf2 downregulation is likely to play a role in malignant phenotypes of triple-negative breast cancer cells." -other hsa-mir-16 "Carcinoma, Breast, Triple Negative" 24485087 "This study provides evidence of posttranscriptional downregulation of Smurf2 in triple-negative breast cancers, and demonstrates that the loss of RB function is involved in microRNA-mediated interference with Smurf2 translation.The new link from RB inactivation to Smurf2 downregulation is likely to play a role in malignant phenotypes of triple-negative breast cancer cells." -other hsa-mir-138 Cardiovascular Diseases [unspecific] 24486907 Induction of microRNA-138 by pro-inflammatory cytokines causes endothelial cell dysfunction. -other hsa-mir-21 Breast Neoplasms 24488617 The difference in miR-21 expression levels between invasive and non-invasive breast cancers emphasizes its role in breast cancer invasion. -other hsa-mir-1228 Neoplasms [unspecific] 24488924 Human miR-1228 as a stable endogenous control for the quantification of circulating microRNAs in cancer patients. -other hsa-mir-146b Breast Neoplasms 24498150 Unraveling the hidden heterogeneities of breast cancer based on functional miRNA cluster. -other hsa-mir-10b Neoplasms [unspecific] 24503738 Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor. -other hsa-mir-23b Glioma 24503899 A lentivirus-mediated miR-23b sponge diminishes the malignant phenotype of glioma cells in vitro and in vivo. -other hsa-let-7 Lung Neoplasms 24505620 Mechanistic links between COPD and lung cancer: a role of microRNA let-7 -other hsa-mir-423 Heart Failure 24506564 The difference in transcoronary gradients between HF outpatients and controls suggests that miR-423-5p has a cardiac origin. The positive correlation between miR-423-5p and BNP transcoronary gradients supports this hypothesis. -other hsa-mir-21 Neoplasms [unspecific] 24507038 "Our results demonstrated that HIF-1α could significantly upregulate α-smooth muscle actin expression, and reduced the E-cadherin expression in HK-2 cells during I/R injury. Moreover, miR-21 expression had a positive correlation with HIF-1α in this process." -other hsa-mir-145 Myelodysplastic Syndromes 24507813 "Other genes, as well as miR-145 and miR-146a, contribute to aberrant megakaryopoiesis and a selective advantage for the del(5q) clone." -other hsa-mir-192 Kidney Diseases [unspecific] 24508230 miR-192 induces G2/M growth arrest in aristolochic acid nephropathy. -other hsa-mir-429 Colorectal Carcinoma 24510588 "miR-200a, miR-200c, miR-141, and miR-429 expression levels may identify CRC patients, including those with stage II disease, who are most likely to benefit from adjuvant chemotherapy." -other hsa-mir-17 Feingold Syndrome 24511118 MicroRNA-17~92 is required for nephrogenesis and renal function. -other hsa-mir-18 Feingold Syndrome 24511118 MicroRNA-17~92 is required for nephrogenesis and renal function. -other hsa-mir-19a Feingold Syndrome 24511118 MicroRNA-17~92 is required for nephrogenesis and renal function. -other hsa-mir-19b-1 Feingold Syndrome 24511118 MicroRNA-17~92 is required for nephrogenesis and renal function. -other hsa-mir-20a Feingold Syndrome 24511118 MicroRNA-17~92 is required for nephrogenesis and renal function. -other hsa-mir-92-1 Feingold Syndrome 24511118 MicroRNA-17~92 is required for nephrogenesis and renal function. -other hsa-mir-335 "Carcinoma, Ovarian" 24515774 Our results indicate that miR-335 relates to the prognosis of patients with EOC and is a promising predictor of EOC recurrence. -other hsa-mir-155 Encephalitis 24516198 Critical role of microRNA-155 in herpes simplex encephalitis. miR-H2 -other hsa-mir-200 Breast Neoplasms 24518294 ¦Â1 integrin inhibition elicits a prometastatic switch through the TGF¦Â-miR-200-ZEB network in E-cadherin-positive triple-negative breast cancer. -other hsa-mir-92a Viral Infectious Disease 24518554 Reply to Shin and Bayry on An age-related decline of CD62L and vaccine response: a role of microRNA 92a. -other hsa-mir-203 "Squamous Cell Carcinoma, Esophageal" 24519530 Research on the typical miRNA and target genes in squamous cell carcinoma and adenocarcinoma of esophagus cancer with DNA microarray. -other hsa-mir-21 "Squamous Cell Carcinoma, Esophageal" 24519530 Research on the typical miRNA and target genes in squamous cell carcinoma and adenocarcinoma of esophagus cancer with DNA microarray. -other hsa-mir-155 Atopic Dermatitis 24521175 The presented concept offers a new option for the prevention of atopic diseases by the addition of physiological amounts of miR-155-enriched exosomes to infant formula for mothers incapable of breastfeeding. -other hsa-mir-200a Pancreatic Neoplasms 24521357 MiR-200a inhibits epithelial-mesenchymal transition of pancreatic cancer stem cell. -other hsa-mir-143 Osteosarcoma 24525123 Exosome-formed synthetic microRNA-143 is transferred to osteosarcoma cells and inhibits their migration. -other hsa-mir-155 Coronary Artery Disease 24525789 "miR-155 expression is associated inversely with complicated proatherogenic metabolic risk factors, and the severity of coronary stenotic lesions calculated by Gensini scores." -other hsa-mir-155 Lung Neoplasms 24528019 "As Hsa-miR-155 (miR-155) can be used as a diagnostic marker for non-small cell lung cancer (NSCLC), a smart molecular beacon of miR-155 was designed to image the expression of miR-155 in NSCLC cases." -other hsa-mir-150 Skin Disease [unspecific] 24530178 "miR-150 levels were significantly decreased in sera of scleroderma patients, and were inversely correlated with the prevalence of pitting scars/ulcers and the incidence of anti-topoisomerase I antibody." -other hsa-mir-140 "Carcinoma, Tounge" 24530397 Reciprocal effects between microRNA-140-5p and ADAM10 suppress migration and invasion of human tongue cancer cells. -other hsa-mir-95 "Carcinoma, Hepatocellular" 24530415 Role of microRNA-95 in the anticancer activity of Brucein D in hepatocellular carcinoma. -other hsa-mir-122 "Carcinoma, Hepatocellular" 24531873 Antitumor function of microRNA-122 against hepatocellular carcinoma. -other hsa-mir-34 Neoplasms [unspecific] 24532687 "Taken together, our results elucidated the intricate cross-talk between p53 and miR-34 miRNAs and revealed an important tumor suppressor effect generated by this positive feedback loop." -other hsa-mir-493 "Carcinoma, Colon" 24533778 MKK7 mediates miR-493-dependent suppression of liver metastasis of colon cancer cells. -other hsa-mir-132 Epilepsy 24553459 "miRNA represents a potentially important mechanism controlling protein levels in epilepsy. As such, miRNAs might be targeted to prevent or disrupt epilepsy as well as serve as diagnostic biomarkers of epileptogenesis." -other hsa-mir-146a Epilepsy 24553459 "miRNA represents a potentially important mechanism controlling protein levels in epilepsy. As such, miRNAs might be targeted to prevent or disrupt epilepsy as well as serve as diagnostic biomarkers of epileptogenesis." -other hsa-mir-23a Epilepsy 24553459 "miRNA represents a potentially important mechanism controlling protein levels in epilepsy. As such, miRNAs might be targeted to prevent or disrupt epilepsy as well as serve as diagnostic biomarkers of epileptogenesis." -other hsa-mir-34a Epilepsy 24553459 "miRNA represents a potentially important mechanism controlling protein levels in epilepsy. As such, miRNAs might be targeted to prevent or disrupt epilepsy as well as serve as diagnostic biomarkers of epileptogenesis." -other hsa-mir-34b Pleural Mesothelioma 24553485 Preclinical evaluation of microRNA-34b/c delivery for malignant pleural mesothelioma. -other hsa-mir-34c Pleural Mesothelioma 24553485 Preclinical evaluation of microRNA-34b/c delivery for malignant pleural mesothelioma. -other hsa-mir-137 Schizophrenia 24556472 Transcriptional consequences of schizophrenia candidate miR-137 manipulation in human neural progenitor cells. -other hsa-mir-548 Neoplasms [unspecific] 24556720 Identification of a tumor-suppressive human-specific microRNA within the FHIT tumor-suppressor gene. -other hsa-mir-124 Diabetic Nephropathy 24556741 These results provide a novel idea that curcumin prevents against podocytic adhesive capacity damage under mechanical stress by inhibitting miR-124 -other hsa-mir-146a Enterovirus Infection 24561744 Inhibition of miR-146a prevents enterovirus-induced death by restoring the production of type I interferon. -other hsa-mir-21 Atherosclerosis 24562307 "In ox-LDL treated VECs, transfection with a miR-21 mimic significantly increased miR-21 expression and inhibited PTEN expression, and attenuated the protective effects of paeonol pretreatment, whereas transfection with an miR-21 inhibitor significantly decreased miR-21 expression and increased PTEN expression, thus enhanced the protective effects of paeonol pretreatment." -other hsa-mir-137 Schizophrenia 24566148 miR-137: a new player in schizophrenia. -other hsa-mir-7 Gastric Neoplasms 24573489 miR-7 inhibits the invasion and metastasis of gastric cancer cells by suppressing epidermal growth factor receptor expression. -other hsa-mir-29 Neoplasms [unspecific] 24573597 Our review highlights the diverse relationship between miR-29 and cancer (particularly digestive system neoplasms). -other hsa-mir-21 Kidney Diseases [unspecific] 24576069 This review was performed to sum up the role of miR-21 and its signaling pathways in renal diseases. -other hsa-mir-146a Colorectal Carcinoma 24576899 A microRNA-operated switch of asymmetric-to-symmetric cancer stem cell divisions. -other hsa-mir-101 "Lymphoma, Burkitt" 24577510 "Histone deacetylase inhibitor prevents cell growth in Burkitt's lymphoma by regulating PI3K/Akt pathways and leads to upregulation of miR-143, miR-145, and miR-101." -other hsa-mir-143 "Lymphoma, Burkitt" 24577510 "Histone deacetylase inhibitor prevents cell growth in Burkitt's lymphoma by regulating PI3K/Akt pathways and leads to upregulation of miR-143, miR-145, and miR-101." -other hsa-mir-145 "Lymphoma, Burkitt" 24577510 "Histone deacetylase inhibitor prevents cell growth in Burkitt's lymphoma by regulating PI3K/Akt pathways and leads to upregulation of miR-143, miR-145, and miR-101." -other hsa-mir-146a Toxoplasma gondii Infection 24582962 miR-146a and miR-155 delineate a MicroRNA fingerprint associated with Toxoplasma persistence in the host brain. -other hsa-mir-155 Toxoplasma gondii Infection 24582962 miR-146a and miR-155 delineate a MicroRNA fingerprint associated with Toxoplasma persistence in the host brain. -other hsa-mir-17 Toxoplasma gondii Infection 24583285 "Taken together, we describe a novel STAT3-miR-17-92-Bim pathway, thus providing a mechanistic explanation for inhibition of apoptosis of host cells following Toxoplasma infection." -other hsa-mir-34a Neoplasms [unspecific] 24583844 miR-34a/SIRT6 in squamous differentiation and cancer. -other hsa-mir-183 Lung Neoplasms 24586048 TGF-¦Â-inducible microRNA-183 silences tumor-associated natural killer cells. -other hsa-mir-376a Viral Infectious Disease 24586166 MicroRNA editing facilitates immune elimination of HCMV infected cells. -other hsa-mir-210 Neoplasms [unspecific] 24586608 "This systematic review and meta-analysis suggests that miR-210 has a predictive effect on survival of patients with studied cancer types as indexed by disease-free survival, progression-free survival and relapse-free survival. While the predictive effect on overall survival, breast cancer overall survival, breast cancer disease-free survival, sarcoma overall survival and renal cancer overall survival was not statistically significant." -other hsa-mir-190b "Carcinoma, Hepatocellular" 24586785 Increased expression of miR-190 may cause decreased IGF-1 in HCC development. Insulin resistance appears to be a part of the physiopathologic significance of decreased IGF-1 levels in HCC progression. This study provides a novel miRNA-mediated regulatory mechanism for controlling IGF-1 expression in HCC and elucidates the biological relevance of this interaction in HCC. -other hsa-mir-34a Multiple Myeloma 24587182 In vivo activity of miR-34a mimics delivered by stable nucleic acid lipid particles (SNALPs) against multiple myeloma. -other hsa-mir-145 "Carcinoma, Endometrial" 24589415 Linc-RoR is a ceRNA and acts as a miR-145 sponge to inhibit mediation of the differentiation of ETs by miR-145. These results suggest that linc-RoR has an important role during endometrial carcinogenesis. -other hsa-mir-155 Hepatitis C Virus Infection 24591085 MicroRNA-155 and microRNA-196b: promising biomarkers in hepatitis C virus infection -other hsa-mir-196b Hepatitis C Virus Infection 24591085 MicroRNA-155 and microRNA-196b: promising biomarkers in hepatitis C virus infection -other hsa-mir-210 Breast Neoplasms 24591754 "Our studies suggested that microRNA-210 could predict the outcome of patients with varieties of tumors, especially in breast cancers." -other hsa-mir-499 Neoplasms [unspecific] 24593893 These results suggest that miR-499 delivered by the present system has excellent potency to treat cancer via integrative anticancer actions. -other hsa-mir-34a "Carcinoma, Lung, Non-Small-Cell" 24595209 The microRNA miR-34a inhibits non-small cell lung cancer (NSCLC) growth and the CD44hi stem-like NSCLC cells. -other hsa-mir-10 "Leukemia, Myeloid, Acute" 24596420 Implications of the miR-10 family in chemotherapy response of NPM1-mutated AML. -other hsa-mir-210 Chronic Hepatitis B 24597695 Studying the association of microRNA-210 level with chronic hepatitis B progression. -other hsa-mir-107 Kidney Diseases [unspecific] 24597825 This review was performed to sum up the role of miR-107 and its signaling pathways in renal diseases. -other hsa-mir-126 Multiple Sclerosis 24598267 "Our findings provided deeper insight into the mode of action of natalizumab, with possible implications for understanding both the effects of natalizumab on MS activity and its specific adverse event profile." -other hsa-mir-155 Sepsis 24598292 "The result of this study suggest that miR-155 is involved in the cell proliferation regulation of CD4(+)CD25(+) Treg cells, and play some role in the immunological dissonance in sepsis." -other hsa-mir-17 Neoplasms [unspecific] 24598644 Effect of microRNA-17-92 cluster on the biological characteristics of K562 cells and its mechanisms. -other hsa-mir-200 Viral Infectious Disease 24599990 Host microRNA regulation of human cytomegalovirus immediate early protein translation promotes viral latency. -other hsa-mir-16 Pancreatic Neoplasms 24600978 The combination of miR-16 and CA19-9 detections boosted the diagnostic performance in pancreatic cancer detection. -other hsa-mir-7 Glioblastoma 24603851 miR-7 inhibits glioblastoma growth by simultaneously interfering with the PI3K/ATK and Raf/MEK/ERK pathways. -other hsa-mir-155 Neuroinflammation 24604078 MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation. -other hsa-mir-208 Pancreatic Neoplasms 24604208 miR-208-induced epithelial to mesenchymal transition of pancreatic cancer cells promotes cell metastasis and invasion. -other hsa-mir-494 Gastric Neoplasms 24606447 Cinobufacin suppresses cell proliferation via miR-494 in BGC- 823 gastric cancer cells. -other hsa-mir-21 Retinoblastoma 24607444 Seed-targeting anti-miR-21 inhibiting malignant progression of retinoblastoma and analysis of their phosphorylation signaling pathways. -other hsa-mir-146a Inflammation 24607549 "In conclusion several aging-related mitomiRs may play a direct role in controlling mitochondrial function by regulating mitochondrial protein expression. Their modulation could thus mediate the loss of mitochondrial integrity and function in aging cells, inducing or contributing to the inflammatory response and to age-related diseases." -other hsa-mir-34a Inflammation 24607549 "In conclusion several aging-related mitomiRs may play a direct role in controlling mitochondrial function by regulating mitochondrial protein expression. Their modulation could thus mediate the loss of mitochondrial integrity and function in aging cells, inducing or contributing to the inflammatory response and to age-related diseases." -other hsa-mir-199a Kidney Neoplasms 24609899 miR-199a-3p inhibits hepatocyte growth factor/c-Met signaling in renal cancer carcinoma. -other hsa-mir-133b Prostate Neoplasms 24610824 "miR-133b might enhance tumor-promoting properties in less aggressive LNCaP cells, whereas this miR may act as a tumor suppressor in more aggressive PC-3 cells. miR-133b and RB1CC1 were independent prognostic indicators for prostate cancer." -other hsa-mir-214 Gastric Neoplasms 24614175 Clinicopathological significance of microRNA-214 in gastric cancer and its effect on cell biological behaviour. -other hsa-mir-27b "Carcinoma, Hepatocellular" 24614526 Fumonisin B modulates expression of human cytochrome P450 1b1 in human hepatoma (Hepg2) cells by repressing Mir-27b. -other hsa-mir-182 Colorectal Adenocarcinoma 24615484 The increased levels of the oncogene-like miR-182 increase the risk for disease progression and predict poor overall survival for colorectal adenocarcinoma patients. -other hsa-mir-214 Colorectal Carcinoma 24616020 Identification of microRNA-214 as a negative regulator of colorectal cancer liver metastasis by way of regulation of fibroblast growth factor receptor 1 expression. -other hsa-mir-648 Prostate Neoplasms 24618011 Our analysis revealed the scale-free features of the human miRNA-mRNA interaction network and showed the distinctive topological features of existing cancer miRNA biomarkers from previously published studies. A novel cancer miRNA biomarker prediction framework was designed based on these observations and applied to prostate cancer study. This method could be applied for miRNA biomarker prediction in other cancers. -other hsa-mir-150 "Lymphoma, T-Cell, Cutaneous" 24627548 "In this issue of Blood, Ito et al demonstrate pathogenic implications of microRNA-150 (miR-150) repression in an aggressive form of cutaneous T-cell lymphoma (CTCL)." -other hsa-mir-424 Psoriatic Arthritis 24628460 miR-424 levels in hair shaft are increased in psoriatic patients. -other hsa-mir-15a "Leukemia, Myeloid, Chronic" 24629639 "We found that dasatinib (DAS) modulated miR-let-7d, miR-let-7e, miR-15a, miR-16, miR-21, miR-130a and miR-142-3p expressions while IM modulated miR-15a and miR-130a levels. miR-16, miR-130a and miR-145 expressions were modulated by nilotinib (NIL)." -other hsa-mir-145 "Carcinoma, Hepatocellular" 24630966 MicroRNA-145: a promising biomarker for hepatocellular carcinoma (HCC). -other hsa-mir-210 Colorectal Carcinoma 24632577 Hypoxia-inducible MiR-210 is an independent prognostic factor and contributes to metastasis in colorectal cancer. -other hsa-mir-148b Colorectal Carcinoma 24632606 Altered p53 regulation of miR-148b and p55PIK contributes to tumor progression in colorectal cancer. -other hsa-mir-18a "Carcinoma, Breast" 24633304 Our findings identify a mechanically regulated microRNA circuit that can promote malignancy and suggest potential prognostic roles for HOXA9 and miR-18a levels in stratifying patients with luminal breast cancers. -other hsa-mir-150 Lymphoma 24633319 The previously reported up-regulation of miR-150 in marginal zone lymphoma of MALT type was verified in an independent cohort of lymphoma samples employing a modified methodology. This further substantiates the role of miR-150 as a potential oncomiR in MALT lymphoma. -other hsa-mir-150 Early-Stage Small-Cell Lung Carcinoma 24637927 A microRNA signature predicts survival in early stage small-cell lung cancer treated with surgery and adjuvant chemotherapy. -other hsa-mir-886 Early-Stage Small-Cell Lung Carcinoma 24637927 A microRNA signature predicts survival in early stage small-cell lung cancer treated with surgery and adjuvant chemotherapy. -other hsa-mir-29 Crohn Disease 24641356 In Crohn's disease fibrosis-reduced expression of the miR-29 family enhances collagen expression in intestinal fibroblasts. -other hsa-mir-144 Cardiovascular Diseases [unspecific] 24642088 7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144. -other hsa-let-7a Ovarian Neoplasms 24643702 "E(2) + P4 significantly inhibited the cell survival, promoted the cell apoptosis, induced the expression of let-7a and miR-34b, and reduced the expression of Bcl-2 in ovarian cancer cells." -other hsa-mir-34b Ovarian Neoplasms 24643702 "E(2) + P4 significantly inhibited the cell survival, promoted the cell apoptosis, induced the expression of let-7a and miR-34b, and reduced the expression of Bcl-2 in ovarian cancer cells." -other hsa-mir-106 Gastric Neoplasms 24643999 "Genetic association of gastric cancer with miRNA clusters including the cancer-related genes MIR29, MIR25, MIR93 and MIR106: results from the EPIC-EURGAST study." -other hsa-mir-25 Gastric Neoplasms 24643999 "Genetic association of gastric cancer with miRNA clusters including the cancer-related genes MIR29, MIR25, MIR93 and MIR106: results from the EPIC-EURGAST study." -other hsa-mir-29 Gastric Neoplasms 24643999 "Genetic association of gastric cancer with miRNA clusters including the cancer-related genes MIR29, MIR25, MIR93 and MIR106: results from the EPIC-EURGAST study." -other hsa-mir-93 Gastric Neoplasms 24643999 "Genetic association of gastric cancer with miRNA clusters including the cancer-related genes MIR29, MIR25, MIR93 and MIR106: results from the EPIC-EURGAST study." -other hsa-mir-200c Prostate Neoplasms 24646496 Words of wisdom: Re: TMPRSS2-ERG gene fusions induce prostate tumorigenesis by modulating microRNA miR-200c. -other hsa-mir-141 "Carcinoma, Renal Cell" 24647573 miR-141 serves as a potential biomarker for discriminating ccRCC from normal tissues and a crucial suppressor of ccRCC cell proliferation and metastasis by modulating the EphA2/p-FAK/p-AKT/MMPs signaling cascade. -other hsa-mir-200c Liver Neoplasms 24647918 Synergistic antitumor activity of resveratrol and miR-200c in human lung cancer. -other hsa-mir-452 Breast Neoplasms 24648265 MicroRNA-452 contributes to the docetaxel resistance of breast cancer cells. -other hsa-let-7a "Lymphoma, Non-Hodgkin" 24648290 "Accordingly, c-Myc-targeting microRNAs let-7a and miR-26a were induced in all treated lymphomas and the cap-dependent translation machinery components 4E-BP1, eIF4E and eIF4G, as well as their upstream regulators, Akt and PIM kinases, were inhibited in function of the cell sensitivity to ITF2357, and, in turn, c-Myc downregulation." -other hsa-mir-26a "Lymphoma, Non-Hodgkin" 24648290 "Accordingly, c-Myc-targeting microRNAs let-7a and miR-26a were induced in all treated lymphomas and the cap-dependent translation machinery components 4E-BP1, eIF4E and eIF4G, as well as their upstream regulators, Akt and PIM kinases, were inhibited in function of the cell sensitivity to ITF2357, and, in turn, c-Myc downregulation." -other hsa-mir-378a Neoplasms [unspecific] 24651706 A screen identifies the oncogenic micro-RNA miR-378a-5p as a negative regulator of oncogene-induced senescence. -other hsa-mir-223 Cardiovascular Diseases [unspecific] 24657505 miR-223 is one of the growing number of RNA biomarkers of various human metabolic diseases and is thus of special interest to both researchers and clinicians in the cardiovascular field. -other hsa-mir-132 Toxoplasma gondii Infection 24657774 MicroRNA-132 dysregulation in Toxoplasma gondii infection has implications for dopamine signaling pathway. -other hsa-mir-145 Neoplasms [unspecific] 24657914 miR-145 and its influence on tumor growth in systemic malignancies. -other hsa-mir-17 Breast Neoplasms 24658544 miR-17/20 sensitization of breast cancer cells to chemotherapy-induced apoptosis requires Akt1. -other hsa-mir-20 Breast Neoplasms 24658544 miR-17/20 sensitization of breast cancer cells to chemotherapy-induced apoptosis requires Akt1. -other hsa-let-7i Breast Neoplasms 24662829 "In breast cancer patients, significantly decreased let-7i levels were associated with missense mutations in p53." -other hsa-mir-122 Chronic Hepatitis C 24672032 Reduction of microRNA 122 expression in IFNL3 CT/TT carriers and during progression of fibrosis in patients with chronic hepatitis C. -other hsa-mir-221 Gastrointestinal Stromal Tumor 24674454 Multiple sporadic gastrointestinal stromal tumors concomitant with ampullary adenocarcinoma: a case report with KIT and PDGFRA mutational analysis and miR-221/222 expression profile. -other hsa-mir-222 Gastrointestinal Stromal Tumor 24674454 Multiple sporadic gastrointestinal stromal tumors concomitant with ampullary adenocarcinoma: a case report with KIT and PDGFRA mutational analysis and miR-221/222 expression profile. -other hsa-mir-940 Neoplasms [unspecific] 24675421 Retaining MKP1 expression and attenuating JNK-mediated apoptosis by RIP1 for cisplatin resistance through miR-940 inhibition. -other hsa-mir-21 Ischemia-Reperfusion Injury 24676391 microRNA-21 protects against ischemia-reperfusion and hypoxia-reperfusion-induced cardiocyte apoptosis via the phosphatase and tensin homolog/Akt-dependent mechanism. -other hsa-mir-21 "Squamous Cell Carcinoma, Oral" 24676554 STAT3 inhibitor WP1066 attenuates miRNA-21 to suppress human oral squamous cell carcinoma growth in vitro and in vivo. -other hsa-mir-24 Hyperlipidemia 24677249 Inhibition of microRNA-24 expression in liver prevents hepatic lipid accumulation and hyperlipidemia. -other hsa-mir-130a Fatty Liver [unspecific] 24677715 A novel function of microRNA 130a-3p in hepatic insulin sensitivity and liver steatosis. -other hsa-mir-203 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 24682952 MiR-203 is downregulated in laryngeal squamous cell carcinoma and can suppress proliferation and induce apoptosis of tumours. -other hsa-mir-155 Neoplasms [unspecific] 24687397 "In HepG2 cells, exogenous NO increases miR-155 expression, but endogenous basal NO inhibits it. Both effects are mediated via cGMP/PKG signaling. The upregulation of miR-155 by NO provides a new link between NO, inflammation, and cancer." -other hsa-mir-122 "Carcinoma, Hepatocellular, HCV-Related" 24690114 Regulation of gene expression by microRNA in HCV infection and HCV-mediated hepatocellular carcinoma. -other hsa-mir-194 "Adenocarcinoma, Colon" 24691499 miR-194 as a predictor for adenoma recurrence in patients with advanced colorectal adenoma after polypectomy. -other hsa-mir-138 Lung Neoplasms 24691972 Up-regulation of microRNA-138 induce radiosensitization in lung cancer cells. -other hsa-mir-203 "Squamous Cell Carcinoma, Esophageal" 24692008 MicroRNA-203 inhibits the progression of esophageal squamous cell carcinoma with restored epithelial tissue architecture in vivo. -other hsa-mir-101 "Carcinoma, Hepatocellular, HBV-Related" 24697700 Functional analysis of miR-101-3p and Rap1b involved in hepatitis B virus-related hepatocellular carcinoma pathogenesis. -other hsa-let-7 Neoplasms [unspecific] 24703842 We conclude that IMP3 RNPs may function as cytoplasmic safe houses and prevent miRNA-directed mRNA decay of oncogenes during tumor progression. -other hsa-mir-612 Liver Neoplasms 24704424 MiR-612 suppresses the stemness of liver cancer via Wnt/¦Â-catenin signaling. -other hsa-mir-302 Neoplasms [unspecific] 24705778 "In conclusion, the controversial role of miR-302-367 in different cell types may provide better understanding for its role in stemness level and its antitumorigenicity potential in different contexts." -other hsa-mir-218 Gastrointestinal Stromal Tumor 24706111 microRNA-218 increase the sensitivity of gastrointestinal stromal tumor to imatinib through PI3K/AKT pathway. -other hsa-mir-7 Breast Neoplasms 24707474 Trichostatin A suppresses EGFR expression through induction of microRNA-7 in an HDAC-independent manner in lapatinib-treated cells. -other hsa-mir-155 "Leukemia, Myeloid, Acute" 24708856 "This study provides evidence for an anti-leukaemic role for miR-155 in human FLT3-wildtype AML, by inducing cell apoptosis and myelomonocytic differentiation, which is in contrast to its previously hypothesized role as an oncogene. This highlights the complexity of gene regulation by microRNAs that may have tumour repressor or oncogenic effects depending on disease context or tissue type." -other hsa-mir-375 Neoplasms [unspecific] 24708873 "Taken together, miR-375-mediated suppression of multiple oncogenic components in HPV-associated carcinogenesis generates a cumulative biological response to rescue key tumor suppressors and diminish telomerase activity, which results in cell cycle arrest and cell proliferation inhibition." -other hsa-mir-208b Heart Failure 24714087 "These results demonstrated that circulating miR-208b and miR-34a could be useful biomarkers for predicting left ventricular remodeling after AMI, and the miRNA levels are associated with increased risk of mortality or heart failure." -other hsa-mir-34a Heart Failure 24714087 "These results demonstrated that circulating miR-208b and miR-34a could be useful biomarkers for predicting left ventricular remodeling after AMI, and the miRNA levels are associated with increased risk of mortality or heart failure." -other hsa-mir-451 Glioma 24714982 Selective ¦Â2 adrenergic agonist increases Cx43 and miR-451 expression via cAMP-Epac. -other hsa-mir-22 "Carcinoma, Endometrial" 24715036 miR-22 inhibits proliferation and invasion in estrogen receptor ¦Á-positive endometrial endometrioid carcinomas cells. -other hsa-mir-210 "Carcinoma, Ovarian" 24715221 Hypoxia-induced miR-210 in epithelial ovarian cancer enhances cancer cell viability via promoting proliferation and inhibiting apoptosis. -other hsa-mir-130b Prostate Neoplasms 24715691 "In addition to downregulation of the large tumor suppressor homolog2 and the programmed cell death protein 4, a neoplastic transformation inhibitor, the tumorigenic reprogramming of pASCs was associated with trafficking by PC cell-derived exosomes of oncogenic factors, including H-ras and K-ras transcripts, oncomiRNAs miR-125b, miR-130b, and miR-155 as well as the Ras superfamily of GTPases Rab1a, Rab1b, and Rab11a." -other hsa-mir-155 Neoplasms [unspecific] 24716910 "MiR-421, miR-155 and miR-650: emerging trends of regulation of cancer and apoptosis." -other hsa-mir-421 Neoplasms [unspecific] 24716910 "MiR-421, miR-155 and miR-650: emerging trends of regulation of cancer and apoptosis." -other hsa-mir-650 Neoplasms [unspecific] 24716910 "MiR-421, miR-155 and miR-650: emerging trends of regulation of cancer and apoptosis." -other hsa-mir-375 Gastric Neoplasms 24718681 miR-375 inhibits Helicobacter pylori-induced gastric carcinogenesis by blocking JAK2-STAT3 signaling. -other hsa-mir-214 "Carcinoma, Hepatocellular" 24719559 "Addition of NCTD to treat RAW264.7 or TAMs enhanced M1 polarization through increase of miR-214 expression. NCTD significantly inhibited β-catenin expression, which could be reversed by miR-214 inhibitor." -other hsa-mir-210 "Leukemia, Lymphoblastic, Acute, Childhood" 24720529 Effect of microRNA-210 on prognosis and response to chemotherapeutic drugs in pediatric acute lymphoblastic leukemia. -other hsa-mir-122 Hepatitis C Virus Infection 24721497 Hepatitis C virus and human miR-122: insights from the bench to the clinic. -other hsa-mir-34a "Carcinoma, Skin" 24726431 Our results demonstrate that p53 mutations increase apoptotic resistance in keratinocytes by interfering with miR-34a-mediated regulation of SIRT1 expression. -other hsa-mir-223 Breast Neoplasms 24727437 Contact inhibition modulates intracellular levels of miR-223 in a p27kip1-dependent manner. -other hsa-mir-20a Neoplasms [unspecific] 24732804 "Decreased expression of miR-27a/miR-20a:miR-17-5p by PEITC-induced ROS is a key step in triggering the miR-ZBTB Sp cascade leading to downregulation of Sp TFs, and this is due to ROS-dependent epigenetic effects associated with genome-wide shifts in repressor complexes, resulting in decreased expression of Myc and the Myc-regulated miRs." -other hsa-mir-155 Selective IgE Deficiency Disease 24734904 miRNA-155 controls mast cell activation by regulating the PI3K¦Ã pathway and anaphylaxis in a mouse model. -other hsa-mir-135b "Carcinoma, Colon" 24735923 MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. -other hsa-mir-155 Recurrent Spontaneous Abortion 24739646 "The expression of miR-155 and HIF-1¦Á is topically stimulated by oxygen signal.HIF-1¦Á adjusts the transcription and translation of VEGF, which together involved in placental trophoblast invasion and placental angiogenesis.The low expression of miR-155 could interfere with expression of HIF-1¦Á and VEGF,which might be involved in villous vascular dysplasia in URSA." -other hsa-mir-133b Parkinson Disease 24742361 Orchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson's disease. -other hsa-mir-21 Cardiomegaly 24743143 "In particular, a passenger strand miR, miR-21*, was identified as a potent paracrine factor that induces cardiomyocyte hypertrophy when shuttled through exosomes." -other hsa-mir-21 Heart Failure 24743143 "In particular, a passenger strand miR, miR-21*, was identified as a potent paracrine factor that induces cardiomyocyte hypertrophy when shuttled through exosomes." -other hsa-mir-146a Graves Ophthalmopathy 24743332 Increased microRNA-155 and decreased microRNA-146a may promote ocular inflammation and proliferation in Graves' ophthalmopathy. -other hsa-mir-155 Graves Ophthalmopathy 24743332 Increased microRNA-155 and decreased microRNA-146a may promote ocular inflammation and proliferation in Graves' ophthalmopathy. -other hsa-mir-491 Glioblastoma 24747968 Two mature products of MIR-491 coordinate to suppress key cancer hallmarks in glioblastoma. -other hsa-mir-122 "Carcinoma, Hepatocellular, HBV-Related" 24748463 Association of miRNA-122-binding site polymorphism at the interleukin-1 ¦Á gene and its interaction with hepatitis B virus mutations with hepatocellular carcinoma risk. -other hsa-mir-122 Chronic Hepatitis C 24752012 HMOX1 and miR-122 play an important role in the pathogenesis of CHC in HCV mono-and HIV/HCV co-infected patients. Reduced expression of HMOX1 in patients with HIV/HCV co-infection may indicate a worse prognosis in this group. Our results do not support the importance of Bach-1 in repression of HMOX1 in patients with chronic hepatitis C. -other hsa-mir-200c Breast Neoplasms 24754877 Glabridin attenuates the migratory and invasive capacity of breast cancer cells by activating microRNA-200c. -other hsa-mir-23b Neoplasms [unspecific] 24755453 Regulation of miR-23b expression and its dual role on ROS production and tumour development. -other hsa-mir-101 "Carcinoma, Hepatocellular" 24759835 "In human HCC, COX-2 mRNA but not COX-2 protein levels are associated with expression levels of angiogenic factors. MiR-21 levels are not associated with angiogenic molecules. MiR-16 and miR-101 levels do not correlate with COX-2 mRNA and protein levels." -other hsa-mir-16 "Carcinoma, Hepatocellular" 24759835 "In human HCC, COX-2 mRNA but not COX-2 protein levels are associated with expression levels of angiogenic factors. MiR-21 levels are not associated with angiogenic molecules. MiR-16 and miR-101 levels do not correlate with COX-2 mRNA and protein levels." -other hsa-mir-21 "Carcinoma, Hepatocellular" 24759835 "In human HCC, COX-2 mRNA but not COX-2 protein levels are associated with expression levels of angiogenic factors. MiR-21 levels are not associated with angiogenic molecules. MiR-16 and miR-101 levels do not correlate with COX-2 mRNA and protein levels." -other hsa-mir-143 Osteosarcoma 24762226 Propofol inhibits proliferation and invasion of osteosarcoma cells by regulation of microRNA-143 expression. -other hsa-mir-29b "Carcinoma, Ovarian" 24767251 Involvement of miR-29b signaling in the sensitivity to chemotherapy in patients with ovarian carcinoma. -other hsa-mir-155 Atherosclerosis 24767942 We hypothesized that native LDL and oxidized LDL played a key role in modulating the effects of miR-155 on macrophages at different stages of atherosclerosis. -other hsa-mir-552 "Adenocarcinoma, Lung" 24778034 "MicroRNA profiles predict the histology of primary lung carcinomas,and differentiate between primary lung adenocarcinomas and colorectal cancer metastases." -other hsa-mir-552 Colorectal Carcinoma 24778034 "MicroRNA profiles predict the histology of primary lung carcinomas,and differentiate between primary lung adenocarcinomas and colorectal cancer metastases." -other hsa-mir-592 "Adenocarcinoma, Lung" 24778034 "MicroRNA profiles predict the histology of primary lung carcinomas,and differentiate between primary lung adenocarcinomas and colorectal cancer metastases." -other hsa-mir-592 Colorectal Carcinoma 24778034 "MicroRNA profiles predict the histology of primary lung carcinomas,and differentiate between primary lung adenocarcinomas and colorectal cancer metastases." -other hsa-mir-125b Rheumatoid Arthritis 24778468 Circulating miRNA-125b is a potential biomarker predicting response to rituximab in rheumatoid arthritis. -other hsa-mir-31 "Carcinoma, Endometrial" 24779718 MIR31 functions as an oncogene in endometrial cancer by repressing the Hippo pathway. MIR31 is a potential new molecular marker for predicting the risk of recurrence and prognosis of endometrial cancer. -other hsa-mir-21 Colorectal Carcinoma 24780321 Correlation of over-expressions of miR-21 and Notch-1 in human colorectal cancer with clinical stages. -other hsa-mir-223 Osteosarcoma 24784921 Prognostic value of microRNA-223/epithelial cell transforming sequence 2 signaling in patients with osteosarcoma. -other hsa-mir-224 Glioblastoma 24785373 MiR-224 expression increases radiation sensitivity of glioblastoma cells. -other hsa-mir-26a Lung Neoplasms 24788552 MicroRNA-26a involved in Toll-like receptor 9-mediated lung cancer growth and migration. -other hsa-mir-126 "Squamous Cell Carcinoma, Oral" 24789258 Suppressive effect of microRNA-126 on oral squamous cell carcinoma in vitro. -other hsa-mir-486 Muscular Dystrophy 24789910 MicroRNA-486-dependent modulation of DOCK3/PTEN/AKT signaling pathways improves muscular dystrophy-associated symptoms. -other hsa-let-7g "Carcinoma, Hepatocellular" 24791593 Let-7g microRNA sensitizes fluorouracil-resistant human hepatoma cells. -other hsa-mir-96 "Squamous Cell Carcinoma, Cerevial" 24791792 Expressions of MicroRNA-96 before and after chemotherapy and its relationship with chemosensitivity in cervical squamous cell carcinoma. -other hsa-mir-200c Lung Neoplasms 24791940 Therapeutic delivery of miR-200c enhances radiosensitivity in lung cancer. -other hsa-mir-10b "Carcinoma, Renal Cell, Clear-Cell" 24793999 The miR(21/10b) ratio as a prognostic marker in clear cell renal cell carcinoma. -other hsa-mir-21 "Carcinoma, Renal Cell, Clear-Cell" 24793999 The miR(21/10b) ratio as a prognostic marker in clear cell renal cell carcinoma. -other hsa-mir-126 Essential Hypertension 24794206 MicroRNA-9 and microRNA-126 expression levels in patients with essential hypertension: potential markers of target-organ damage. -other hsa-mir-9 Essential Hypertension 24794206 MicroRNA-9 and microRNA-126 expression levels in patients with essential hypertension: potential markers of target-organ damage. -other hsa-mir-224 Gastric Neoplasms 24796455 Effect of antisense miR-224 on gastric cancer cell proliferation and apoptosis. -other hsa-mir-34a "Carcinoma, Gastric" 24796666 The RNA-binding protein PCBP2 facilitates gastric carcinoma growth by targeting miR-34a. -other hsa-mir-29 "Carcinoma, Hepatocellular" 24798303 Modulation of miR-29 expression by ¦Á-fetoprotein is linked to the hepatocellular carcinoma epigenome. -other hsa-mir-24 "Carcinoma, Hepatocellular" 24800232 MicroRNA-24 modulates aflatoxin B1-related hepatocellular carcinoma prognosis and tumorigenesis. -other hsa-mir-34c Osteosarcoma 24802328 MiR-34c inhibits osteosarcoma metastasis and chemoresistance. -other hsa-mir-148a "Carcinoma, Hepatocellular" 24806207 The repressive effect of miR-148a on TGF beta-SMADs signal pathway is involved in the glabridin-induced inhibition of the cancer stem cells-like properties in hepatocellular carcinoma cells. -other hsa-mir-23a "Carcinoma, Breast" 24806942 Downregulation of SP1 and increased miR-23a levels in MSCs after contact with tumor cell medium as well as enhanced TGFβ1 expression were identified as potential molecular regulators of CXCL12 activity in MSCs. -other hsa-mir-133a Long QT Syndrome 24809446 MicroRNAs in cardiac arrhythmia: DNA sequence variation of MiR-1 and MiR-133A in long QT syndrome. -other hsa-mir-141 "Carcinoma, Renal Cell" 24810210 Honokiol suppresses renal cancer cells' metastasis via dual-blocking epithelial-mesenchymal transition and cancer stem cell properties through modulating miR-141/ZEB2 signaling. -other hsa-mir-199a "Carcinoma, Thyroid, Papillary" 24810336 miR-199a-3p displays tumor suppressor functions in papillary thyroid carcinoma. -other hsa-mir-200a "Diabetes Mellitus, Type 2" 24812635 "miR-448, let-7b, miR-540, miR-296, miR-880, miR-200a, miR-500, miR-10b, miR-336, miR-30d, miR-208, let-7e, miR-142-5p, miR-874, miR-375, miR-879, miR-501, and miR-188 were upregulated, while miR-301b, miR-134, and miR-652 were downregulated in TMH group." -other hsa-mir-375 "Diabetes Mellitus, Type 2" 24812635 "Through target gene analysis and real-time PCR verification, we found that these miRNAs, especially miR-375 and miR-30d, can stimulate insulin secretion in islet." -other hsa-mir-1915 Colon Neoplasms 24814047 Tumor suppressor p53 induces miR-1915 processing to inhibit Bcl-2 in the apoptotic response to DNA damage. -other hsa-mir-200 Osteosarcoma 24815002 Busulfan inhibits growth of human osteosarcoma through miR-200 family microRNAs in vitro and in vivo. -other hsa-mir-34 Osteoporosis 24815299 "miR-34 has also been implicated in various non-cancerous diseases, such as brain disorders, osteoporosis, and cardiovascular complications." -other hsa-mir-100 Atherosclerosis 24815336 The co-inertia approach in identification of specific microRNA in early and advanced atherosclerosis plaque. -other hsa-mir-127 Atherosclerosis 24815336 The co-inertia approach in identification of specific microRNA in early and advanced atherosclerosis plaque. -other hsa-mir-145 Atherosclerosis 24815336 The co-inertia approach in identification of specific microRNA in early and advanced atherosclerosis plaque. -other hsa-mir-146 Atherosclerosis 24815336 The co-inertia approach in identification of specific microRNA in early and advanced atherosclerosis plaque. -other hsa-mir-155 Atherosclerosis 24815336 The co-inertia approach in identification of specific microRNA in early and advanced atherosclerosis plaque. -other hsa-mir-221 Atherosclerosis 24815336 The co-inertia approach in identification of specific microRNA in early and advanced atherosclerosis plaque. -other hsa-mir-222 Atherosclerosis 24815336 The co-inertia approach in identification of specific microRNA in early and advanced atherosclerosis plaque. -other hsa-mir-24 Atherosclerosis 24815336 The co-inertia approach in identification of specific microRNA in early and advanced atherosclerosis plaque. -other hsa-mir-718 Ovarian Neoplasms 24815691 MiR-718 represses VEGF and inhibits ovarian cancer cell progression. -other hsa-mir-223 Rheumatoid Arthritis 24816316 Increased miR-223 expression in T cells from patients with rheumatoid arthritis leads to decreased insulin-like growth factor-1-mediated interleukin-10 production. -other hsa-mir-133a "Carcinoma, Lung, Non-Small-Cell" 24816813 MicroRNA-133a suppresses multiple oncogenic membrane receptors and cell invasion in non-small cell lung carcinoma. -other hsa-mir-125b Glioblastoma 24817689 MicroRNA expression signatures and their correlation with clinicopathological features in glioblastoma multiforme -other hsa-mir-125a Multiple Myeloma 24819167 A p53-dependent tumor suppressor network is induced by selective miR-125a-5p inhibition in multiple myeloma cells. -other hsa-mir-223 Colorectal Carcinoma 24819398 MicroRNA-223 functions as an oncogene in human colorectal cancer cells. -other hsa-mir-422a Osteoporosis 24820117 MiR-422a as a potential cellular microRNA biomarker for postmenopausal osteoporosis. -other hsa-mir-27 Urinary Bladder Cancer 24821854 3'-Biotin-tagged microRNA-27 does not associate with Argonaute proteins in cells. -other hsa-mir-31 Hepatitis B Virus Infection 24824126 HBsAg regulation of miR-31 expression in HepG2 cells -other hsa-mir-125a Hepatitis B Virus Infection 24824183 Functional interplay between hepatitis B virus X protein and human miR-125a in HBV infection. -other hsa-mir-27a Hepatitis C Virus Infection 24824429 MicroRNA-27a modulates HCV infection in differentiated hepatocyte-like cells from adipose tissue-derived mesenchymal stem cells. -other hsa-mir-22 "Leukemia, Lymphocytic, Chronic, B-Cell" 24825182 Activation of the PI3K/AKT pathway by microRNA-22 results in CLL B-cell proliferation. -other hsa-mir-142 Glioma 24825189 MicroRNA 142-3p attenuates spread of replicating retroviral vector in hematopoietic lineage-derived cells while maintaining an antiviral immune response. -other hsa-mir-320 "Diabetes Mellitus, Type 2" 24825548 Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells. -other hsa-mir-124 "Colitis, Ulcerative" 24825593 attenuation of ischemic and inflammatory injury in cardiomyocytes. -other hsa-mir-21 Myocardial Ischemic-Reperfusion Injury 24825878 Na2S induces cardioprotective effects through miR-21-dependent attenuation of ischemic and inflammatory injury in cardiomyocytes. -other hsa-mir-4728 Breast Neoplasms 24828673 "we present here an alternative mode of miRNA regulation and demonstrate this dual function of the HER2 locus, linking the two major biomarkers in breast cancer." -other hsa-mir-509 Cystic Fibrosis 24829907 Exploitation of a very small peptide nucleic acid as a new inhibitor of miR-509-3p involved in the regulation of cystic fibrosis disease-gene expression. -other hsa-mir-19 Breast Neoplasms 24831732 Curcumin modulates miR-19/PTEN/AKT/p53 axis to suppress bisphenol A-induced MCF-7 breast cancer cell proliferation. -other hsa-mir-21 Colorectal Carcinoma 24832083 nuclear translocation of ¦Â-catenin increased by miR-21 promotes tumour malignancy and a poor outcome in APC-mutated patients but not in APC-wild-type colorectal cancer. -other hsa-mir-221 Central Nervous System Embryonal Tumor 24832085 "Downregulation of SUN2, a novel tumor suppressor, mediates miR-221/222-induced malignancy in central nervous system embryonal tumors." -other hsa-mir-222 Central Nervous System Embryonal Tumor 24832085 "Downregulation of SUN2, a novel tumor suppressor, mediates miR-221/222-induced malignancy in central nervous system embryonal tumors." -other hsa-mir-134 Acute Myocardial Infarction 24833470 Predictive value of circulating miR-328 and miR-134 for acute myocardial infarction. -other hsa-mir-328 Acute Myocardial Infarction 24833470 Predictive value of circulating miR-328 and miR-134 for acute myocardial infarction. -other hsa-mir-126 Atherosclerosis 24833799 MicroRNA-126 in atherosclerosis -other hsa-mir-765 Prostate Neoplasms 24837491 "Hsa-miRNA-765 as a key mediator for inhibiting growth, migration and invasion in fulvestrant-treated prostate cancer." -other hsa-mir-155 Breast Neoplasms 24840899 Increased circulating microRNA-155 as a potential biomarker for breast cancer screening: a meta-analysis. -other hsa-mir-451 "Carcinoma, Hepatocellular" 24841638 miR-451: potential role as tumor suppressor of human hepatoma cell growth and invasion. -other hsa-mir-223 Colorectal Carcinoma 24841830 fecal miR-223 and miR-451 hold promise in detecting CRC. -other hsa-mir-451 Colorectal Carcinoma 24841830 fecal miR-223 and miR-451 hold promise in detecting CRC. -other hsa-mir-218 "Carcinoma, Cervical" 24843318 MicroRNA-218 enhances the radiosensitivity of human cervical cancer via promoting radiation induced apoptosis. -other hsa-mir-122 Hepatitis C Virus Infection 24844965 "Different types of IFN increase the expression of miRNAs that inhibit HCV replication and decrease the expression of miRNA-122 that supports HCV replication. Thus the regulation of HCV replication-related miRNA expression is a general anti-HCV mechanism by different types of IFN. However, the regulation pattern by type II IFN is different from those by other types of IFNs,implying that type II IFN has different anti-HCV mechanisms from other types of IFN at miRNA level." -other hsa-mir-21 "Carcinoma, Hepatocellular" 24845419 Dehydroepiandrosterone-induces miR-21 transcription in HepG2 cells through estrogen receptor ¦Â and androgen receptor. -other hsa-mir-497 Gastric Neoplasms 24845562 The putative tumor suppressor microRNA-497 modulates gastric cancer cell proliferation and invasion by repressing eIF4E. -other hsa-mir-128 "Leukemia, Myeloid, Acute" 24846063 Effect of miR-128 in DNA damage of HL-60 acute myeloid leukemia cells. -other hsa-mir-106b "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 24846066 "miR-21, miR-106b and miR-375 as novel potential biomarkers for laryngeal squamous cell carcinoma." -other hsa-mir-21 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 24846066 "miR-21, miR-106b and miR-375 as novel potential biomarkers for laryngeal squamous cell carcinoma." -other hsa-mir-375 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 24846066 "miR-21, miR-106b and miR-375 as novel potential biomarkers for laryngeal squamous cell carcinoma." -other hsa-mir-200a Cervix Endometrial Stromal Tumor 24850415 "MicroRNA-200a locally attenuates progesterone signaling in the cervix, preventing embryo implantation." -other hsa-mir-26a Idiopathic Pulmonary Fibrosis 24853416 Integrated analyses identify the involvement of microRNA-26a in epithelial-mesenchymal transition during idiopathic pulmonary fibrosis. -other hsa-let-7a Salivary Gland Neoplasms 24853424 "Furthermore, WIF1 significantly increased the expression of microRNAs pri-let-7a and pri-miR-200c, negative regulators of stemness and cancer progression." -other hsa-mir-24 Ischemia-Reperfusion Injury 24854275 MicroRNA-24 antagonism prevents renal ischemia reperfusion injury. -other hsa-mir-127 "Carcinoma, Hepatocellular" 24854842 miR-127 plays a tumor-suppressor role and can serve as a potential diagnostic biomarker for HCC. -other hsa-mir-200a Meningioma 24858044 miR-200a-mediated suppression of non-muscle heavy chain IIb inhibits meningioma cell migration and tumor growth in vivo. -other hsa-mir-142 "Leukemia, Myeloid, Acute" 24858343 The protein phosphatase 2A regulatory subunit B55¦Á is a modulator of signaling and microRNA expression in acute myeloid leukemia cells. -other hsa-mir-191 "Leukemia, Myeloid, Acute" 24858343 The protein phosphatase 2A regulatory subunit B55¦Á is a modulator of signaling and microRNA expression in acute myeloid leukemia cells. -other hsa-mir-122 Glioma 24863942 MiR-122/Wnt/¦Â-catenin regulatory circuitry sustains glioma progression. -other hsa-mir-23 Myocardial Infarction 24864093 MicroRNA--a new diagnostic tool in coronary artery disease and myocardial infarction. -other hsa-mir-103a Breast Neoplasms 24865188 "Association of microRNA-93, 190, 200b and receptor status in core biopsies from stage III breast cancer patients." -other hsa-mir-190a "Carcinoma, Breast, Triple Negative" 24865188 "Association of microRNA-93, 190, 200b and receptor status in core biopsies from stage III breast cancer patients." -other hsa-mir-200b "Carcinoma, Breast, Triple Negative" 24865188 "Association of microRNA-93, 190, 200b and receptor status in core biopsies from stage III breast cancer patients." -other hsa-mir-93 "Carcinoma, Breast, Triple Negative" 24865188 "Association of microRNA-93, 190, 200b and receptor status in core biopsies from stage III breast cancer patients." -other hsa-mir-21 Ovarian Neoplasms 24865582 Upregulation of miR-21 in cisplatin resistant ovarian cancer via JNK-1/c-Jun pathway. -other hsa-mir-181c Brain Neoplasms 24867100 MiRNA-181c inhibits EGFR-signaling-dependent MMP9 activation via suppressing Akt phosphorylation in glioblastoma. -other hsa-mir-126 Atherosclerosis 24870014 These effects may explain the ability of pitavastatin to reduce the progression of atherosclerosis. The findings further suggest that inhibitory effect of pitavastatin on VCAM-1 is not related to miR-126 but depends on other ways. -other hsa-mir-122 Hepatitis C Virus Infection 24871972 "Representatively, miR-122 directly modulates the HCV life cycle by increasing HCV translation and genomic RNA stability." -other hsa-mir-196a Human Immunodeficiency Virus Infection 24872081 Involvement of miR-196a in HIV-associated neurocognitive disorders. -other hsa-mir-17 Leukemia 24872388 Inhibition of miR-17 and miR-20a by oridonin triggers apoptosis and reverses chemoresistance by derepressing BIM-S. -other hsa-mir-20a Leukemia 24872388 Inhibition of miR-17 and miR-20a by oridonin triggers apoptosis and reverses chemoresistance by derepressing BIM-S. -other hsa-mir-10b "Carcinoma, Hepatocellular" 24875649 the study reveals the comprehensive miRNome of hepatic tissue and provides new tools for investigation of microRNA dependent pathways in cirrhotic liver and hepatocellular carcinoma. This article is part of a Directed Issue entitled: Rare Cancers. -other hsa-mir-1269a "Carcinoma, Hepatocellular" 24875649 the study reveals the comprehensive miRNome of hepatic tissue and provides new tools for investigation of microRNA dependent pathways in cirrhotic liver and hepatocellular carcinoma. This article is part of a Directed Issue entitled: Rare Cancers. -other hsa-mir-183 "Carcinoma, Hepatocellular" 24875649 the study reveals the comprehensive miRNome of hepatic tissue and provides new tools for investigation of microRNA dependent pathways in cirrhotic liver and hepatocellular carcinoma. This article is part of a Directed Issue entitled: Rare Cancers. -other hsa-mir-199a "Carcinoma, Hepatocellular" 24875649 the study reveals the comprehensive miRNome of hepatic tissue and provides new tools for investigation of microRNA dependent pathways in cirrhotic liver and hepatocellular carcinoma. This article is part of a Directed Issue entitled: Rare Cancers. -other hsa-mir-199b "Carcinoma, Hepatocellular" 24875649 the study reveals the comprehensive miRNome of hepatic tissue and provides new tools for investigation of microRNA dependent pathways in cirrhotic liver and hepatocellular carcinoma. This article is part of a Directed Issue entitled: Rare Cancers. -other hsa-mir-214 "Carcinoma, Hepatocellular" 24875649 the study reveals the comprehensive miRNome of hepatic tissue and provides new tools for investigation of microRNA dependent pathways in cirrhotic liver and hepatocellular carcinoma. This article is part of a Directed Issue entitled: Rare Cancers. -other hsa-mir-3144 "Carcinoma, Hepatocellular" 24875649 the study reveals the comprehensive miRNome of hepatic tissue and provides new tools for investigation of microRNA dependent pathways in cirrhotic liver and hepatocellular carcinoma. This article is part of a Directed Issue entitled: Rare Cancers. -other hsa-mir-490 "Carcinoma, Hepatocellular" 24875649 the study reveals the comprehensive miRNome of hepatic tissue and provides new tools for investigation of microRNA dependent pathways in cirrhotic liver and hepatocellular carcinoma. This article is part of a Directed Issue entitled: Rare Cancers. -other hsa-mir-106b "Carcinoma, Hepatocellular" 24876719 miR-106b-25/miR-17-92 clusters: polycistrons with oncogenic roles in hepatocellular carcinoma. -other hsa-mir-17 "Carcinoma, Hepatocellular" 24876719 miR-106b-25/miR-17-92 clusters: polycistrons with oncogenic roles in hepatocellular carcinoma. -other hsa-mir-18 "Carcinoma, Hepatocellular" 24876719 miR-106b-25/miR-17-92 clusters: polycistrons with oncogenic roles in hepatocellular carcinoma. -other hsa-mir-19a "Carcinoma, Hepatocellular" 24876719 miR-106b-25/miR-17-92 clusters: polycistrons with oncogenic roles in hepatocellular carcinoma. -other hsa-mir-19b-1 "Carcinoma, Hepatocellular" 24876719 miR-106b-25/miR-17-92 clusters: polycistrons with oncogenic roles in hepatocellular carcinoma. -other hsa-mir-20a "Carcinoma, Hepatocellular" 24876719 miR-106b-25/miR-17-92 clusters: polycistrons with oncogenic roles in hepatocellular carcinoma. -other hsa-mir-92-1 "Carcinoma, Hepatocellular" 24876719 miR-106b-25/miR-17-92 clusters: polycistrons with oncogenic roles in hepatocellular carcinoma. -other hsa-mir-1291 Acute Myocardial Infarction 24885383 "This study demonstrated that the levels of miR-133, miR-1291 and miR-663b are associated with AMI. The potential of these miRNAs as biomarkers to improve patient stratification according to the risk of AMI and as circulating biomarkers for the AMI progonos warrants further study." -other hsa-mir-133 Acute Myocardial Infarction 24885383 "This study demonstrated that the levels of miR-133, miR-1291 and miR-663b are associated with AMI. The potential of these miRNAs as biomarkers to improve patient stratification according to the risk of AMI and as circulating biomarkers for the AMI progonos warrants further study." -other hsa-mir-663b Acute Myocardial Infarction 24885383 "This study demonstrated that the levels of miR-133, miR-1291 and miR-663b are associated with AMI. The potential of these miRNAs as biomarkers to improve patient stratification according to the risk of AMI and as circulating biomarkers for the AMI progonos warrants further study." -other hsa-mir-520b Hepatitis B Virus Infection 24886421 HBx accelerates hepatocarcinogenesis with partner survivin through modulating tumor suppressor miR-520b and oncoprotein HBXIP. -other hsa-mir-221 Breast Neoplasms 24886939 miR-221/222 promotes S-phase entry and cellular migration in control of basal-like breast cancer. -other hsa-mir-222 Breast Neoplasms 24886939 miR-221/222 promotes S-phase entry and cellular migration in control of basal-like breast cancer. -other hsa-mir-940 Tetralogy Of Fallot 24889693 miRNA-940 reduction contributes to human Tetralogy of Fallot development. -other hsa-mir-15b "Carcinoma, Pancreatic" 24892299 Expression of microRNA-15b and the glycosyltransferase GCNT3 correlates with antitumor efficacy of Rosemary diterpenes in colon and pancreatic cancer. -other hsa-mir-15b Colon Neoplasms 24892299 Expression of microRNA-15b and the glycosyltransferase GCNT3 correlates with antitumor efficacy of Rosemary diterpenes in colon and pancreatic cancer. -other hsa-mir-146a "Carcinoma, Hepatocellular" 24895573 Synergistic effect of MiR-146a mimic and cetuximab on hepatocellular carcinoma cells. -other hsa-mir-24 Pancreatic Neoplasms 24895587 The miR-24 was the most significantly powerful miRNA that regulated series of important genes. -other hsa-mir-16 Colorectal Carcinoma 24895601 "Our results have laid down a solid foundation in exploration of novel CRC mechanisms, and identification of miRNA roles as oncomirs or tumor suppressor mirs in CRC." -other hsa-mir-148a Pancreatic Neoplasms 24895996 miR-148a- and miR-216a-regulated oncolytic adenoviruses targeting pancreatic tumors attenuate tissue damage without perturbation of miRNA activity. -other hsa-mir-216a Pancreatic Neoplasms 24895996 miR-148a- and miR-216a-regulated oncolytic adenoviruses targeting pancreatic tumors attenuate tissue damage without perturbation of miRNA activity. -other hsa-mir-125a "Carcinoma, Nasopharyngeal" 24896104 Curcumin exerts inhibitory effects on undifferentiated nasopharyngeal carcinoma by inhibiting the expression of miR-125a-5p. -other hsa-mir-10b Breast Neoplasms 24897960 Our results provide evidences that the addition of miR-10b RERs to the prognostic factors used in clinical routine could improve the prediction abilities for both overall mortality and disease progression in breast cancer patients. -other hsa-mir-16 Multiple Sclerosis 24898268 "Further evidence indicated that DIM treatment significantly upregulated several miRNAs (miR-200c, miR-146a, miR-16, miR-93, and miR-22) in brain CD4(+) T cells during EAE while suppressing their associated target genes." -other hsa-mir-122 "Carcinoma, Colon" 24898807 Overexpression of microRNA-122 re-sensitizes 5-FU-resistant colon cancer cells to 5-FU through the inhibition of PKM2 in vitro and in vivo. -other hsa-mir-23a "Carcinoma, Lung, Non-Small-Cell" 24898878 There is an interaction between miR-23a and IRS-1 in the modulation of the migration and invasion of NSCLC cells. IRS-1 is variably expressed in NSCLC patients and correlates with NSCLC patient survival. -other hsa-mir-451 Glioblastoma 24899919 Those parameters are primarily linked to the reactions that involve the microRNA-451 and the thereof regulated protein MO25. -other hsa-mir-17 Multiple Sclerosis 24901013 Unraveling natalizumab effects on deregulated miR-17 expression in CD4+ T cells of patients with relapsing-remitting multiple sclerosis. -other hsa-mir-125a Obesity 24901105 Our results support the involvement of miR-125a-3p in regulating the insulin signalling pathway and imply that increased miR- 125a-3p expression in omental adipose tissues may be a characteristic feature of insulin resistance in obese men. -other hsa-mir-18a Ischemic Heart Disease 24903055 PNS treatment resulted in reduced expression of miR-18a in tumor and upregulated expression of miR-18a in heart. -other hsa-mir-100 Neoplasms [unspecific] 24903380 "the prognostic role of miR-100 in human cancers, and thus, much more works are needed in this field." -other hsa-mir-221 Breast Neoplasms 24905916 Trail resistance induces epithelial-mesenchymal transition and enhances invasiveness by suppressing PTEN via miR-221 in breast cancer. -other hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 24906642 Downregulation of miR-21 increases cisplatin sensitivity of non-small-cell lung cancer. -other hsa-mir-210 Neoplasms [unspecific] 24909053 Multiple functions of hypoxia-regulated miR-210 in cancer. -other hsa-mir-630 Neoplasms [unspecific] 24909689 E2F1-regulated DROSHA promotes miR-630 biosynthesis in cisplatin-exposed cancer cells. -other hsa-mir-124 Colorectal Carcinoma 24909917 KITENIN-targeting microRNA-124 suppresses colorectal cancer cell motility and tumorigenesis. -other hsa-mir-27a Colorectal Carcinoma 24909917 KITENIN-targeting microRNA-124 suppresses colorectal cancer cell motility and tumorigenesis. -other hsa-mir-30b Colorectal Carcinoma 24909917 KITENIN-targeting microRNA-124 suppresses colorectal cancer cell motility and tumorigenesis. -other hsa-let-7i Acute Ischemic Stroke 24911610 "Several miRNA are differentially expressed in blood cells of patients with acute ischemic stroke. These miRNA may regulate leukocyte gene expression in ischemic stroke including pathways involved in immune activation,leukocyte extravasation and thrombosis." -other hsa-mir-21 Neoplasms [unspecific] 24912785 Exosomal miR-21 derived from arsenite-transformed human bronchial epithelial cells promotes cell proliferation associated with arsenite carcinogenesis. -other hsa-mir-124 Prostate Neoplasms 24913567 "It was clear that PACE4 level was closely associated with malignancy and invasiveness of PCa in vivo or in vitro MiR-124, played a crucial role inhibiting PACE4 transcription thus exhibiting obvious effects of antiproliferation and antiaggression of PCa." -other hsa-mir-581 "Carcinoma, Hepatocellular" 24913918 miR-581 during hepatocarcinogenesis may lead to a reduction in HBsAg expression and impede HCC development. -other hsa-mir-155 "Leukemia, Lymphocytic, Chronic, B-Cell" 24914134 MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia. -other hsa-mir-132 Colorectal Carcinoma 24914372 Our study indicated that miR-132 plays an important role in the invasion and metastasis of CRC. -other hsa-mir-146a Neurodegenerative Diseases [unspecific] 24917789 "These findings together with the reduced expression of microRNA (miR)-124, and miR-155, decreased autophagy, enhanced senescence associated beta-galactosidase activity and elevated miR-146a expression, are suggestive that 16 DIV cells mainly correspond to irresponsive/senescent microglia." -other hsa-mir-146a Cholangiocarcinoma 24918778 "Significant variability was observed in the temporal function of all six miRNAs, which may play an important role in the development of CCA." -other hsa-mir-155 Cholangiocarcinoma 24918778 "Significant variability was observed in the temporal function of all six miRNAs, which may play an important role in the development of CCA." -other hsa-mir-200a Cholangiocarcinoma 24918778 "Significant variability was observed in the temporal function of all six miRNAs, which may play an important role in the development of CCA." -other hsa-mir-200b Cholangiocarcinoma 24918778 "Significant variability was observed in the temporal function of all six miRNAs, which may play an important role in the development of CCA." -other hsa-mir-21 Cholangiocarcinoma 24918778 "Significant variability was observed in the temporal function of all six miRNAs, which may play an important role in the development of CCA." -other hsa-mir-221 Cholangiocarcinoma 24918778 "Significant variability was observed in the temporal function of all six miRNAs, which may play an important role in the development of CCA." -other hsa-mir-17 Melanoma 24920276 Differential regulation of aggressive features in melanoma cells by members of the miR-17-92 complex. -other hsa-mir-18 Melanoma 24920276 Differential regulation of aggressive features in melanoma cells by members of the miR-17-92 complex. -other hsa-mir-19a Melanoma 24920276 Differential regulation of aggressive features in melanoma cells by members of the miR-17-92 complex. -other hsa-mir-19b-1 Melanoma 24920276 Differential regulation of aggressive features in melanoma cells by members of the miR-17-92 complex. -other hsa-mir-20a Melanoma 24920276 Differential regulation of aggressive features in melanoma cells by members of the miR-17-92 complex. -other hsa-mir-92-1 Melanoma 24920276 Differential regulation of aggressive features in melanoma cells by members of the miR-17-92 complex. -other hsa-mir-103 Hematologic Neoplasms 24921248 could discriminate between colorectal recurrences to lymph nodes and liver and between colorectal liver metastasis and primary hepatic tumor. -other hsa-mir-21 Hematologic Neoplasms 24921248 could discriminate between colorectal recurrences to lymph nodes and liver and between colorectal liver metastasis and primary hepatic tumor. -other hsa-mir-31 Hematologic Neoplasms 24921248 could discriminate between colorectal recurrences to lymph nodes and liver and between colorectal liver metastasis and primary hepatic tumor. -other hsa-mir-566 Hematologic Neoplasms 24921248 could discriminate between colorectal recurrences to lymph nodes and liver and between colorectal liver metastasis and primary hepatic tumor. -other hsa-mir-93 Hematologic Neoplasms 24921248 could discriminate between colorectal recurrences to lymph nodes and liver and between colorectal liver metastasis and primary hepatic tumor. -other hsa-mir-222 Breast Neoplasms 24923427 "Overall, this study suggested that both celecoxib and aspirin could prevent breast cancer growth by regulating proteins in the cell cycle and apoptosis without blocking estrogen synthesis. Besides, celecoxib might affect miR expression in an undesirable fashion." -other hsa-mir-378 Obesity 24923530 Insight into the effects of adipose tissue inflammation factors on miR-378 expression and the underlying mechanism. -other hsa-mir-106b Atrial Fibrillation 24927531 "miR-17-92 and miR-106b-25 directly repress genes, such as Shox2 and Tbx3, that are required for sinoatrial node development.Together, to our knowledge, these findings provide the first genetic evidence for an miR loss-of-function that increases atrial fibrillation susceptibility." -other hsa-mir-33a Hyperlipidemia 24928089 "all selected miRNAs were detected in α-lipoprotein fraction from sera, and miR-33a was also present in β-lipoprotein fraction;" -other hsa-mir-188 Osteoarthritis 24928913 "In IL-1β-stimulated human chondrocytes, chosen as a model of differentiated phenotype loss implicating the PPi transporter ANK, miR-9, miR-188 and let7e levels increased." -other hsa-mir-19a Ovarian Neoplasms 24929208 miR-19a was also transported via TnTs connecting transfected K7M2 cells and nontransfected stromal MC3T3 murine osteoblast cells. -other hsa-mir-146b Obesity 24931160 MiR-146b is a regulator of human visceral preadipocyte proliferation and differentiation and its expression is altered in human obesity. -other hsa-mir-126 Atherosclerosis 24933211 "Furthermore, significantly increased aortic expression of miR-26a, miR-21, miR-126a, miR-132, miR-146 and miR-155 and decreased expression of miR-20a and miR-92a were observed in the vehicle-treated ApoE-/- mice. While NR1 treatment led to a significant reduction in the expression of miR-21, miR-26a, miR-126 and increased expression of miR-20a." -other hsa-mir-155 Atherosclerosis 24933211 "Furthermore, significantly increased aortic expression of miR-26a, miR-21, miR-126a, miR-132, miR-146 and miR-155 and decreased expression of miR-20a and miR-92a were observed in the vehicle-treated ApoE-/- mice. While NR1 treatment led to a significant reduction in the expression of miR-21, miR-26a, miR-126 and increased expression of miR-20a." -other hsa-mir-20a Atherosclerosis 24933211 "Furthermore, significantly increased aortic expression of miR-26a, miR-21, miR-126a, miR-132, miR-146 and miR-155 and decreased expression of miR-20a and miR-92a were observed in the vehicle-treated ApoE-/- mice. While NR1 treatment led to a significant reduction in the expression of miR-21, miR-26a, miR-126 and increased expression of miR-20a." -other hsa-mir-133a Hypertension 24937684 "These results suggest that high salt intervention could down-regulate the expression of myocardial microRNA-133a, which may be one of the mechanisms involved in myocardial fibrosis in salt-sensitive hypertension." -other hsa-mir-155 Down Syndrome 24938108 "Analysis of mtDNA, miR-155 and BACH1 expression in hearts from donors with and without Down syndrome." -other hsa-mir-145 Colorectal Adenocarcinoma 24938624 This might be attributable to the fact that effects of miRNA activity may oscillate between gene product repression and activation. -other hsa-mir-21 Colorectal Adenocarcinoma 24938624 This might be attributable to the fact that effects of miRNA activity may oscillate between gene product repression and activation. -other hsa-mir-146a Osteoarthritis 24939082 Role of miR-146a in human chondrocyte apoptosis in response to mechanical pressure injury in vitro. -other hsa-mir-675 "Carcinoma, Hepatocellular" 24939300 inhibition of LncRNAH19 and miR-675 expression can promote migration and invasion of HCC cells via AKT/GSK-3¦Â/Cdc25A signaling pathway. -other hsa-let-7a Breast Neoplasms 24942235 Expression status of let-7a and miR-335 among breast tumors in patients with and without germ-line BRCA mutations. -other hsa-mir-335 Breast Neoplasms 24942235 Expression status of let-7a and miR-335 among breast tumors in patients with and without germ-line BRCA mutations. -other hsa-mir-139 Colorectal Carcinoma 24942287 Post-transcriptional regulation of the tumor suppressor miR-139-5p and a network of miR-139-5p-mediated mRNA interactions in colorectal cancer. -other hsa-mir-107 "Stroke, Ischemic" 24943094 Up-regulation of brain-enriched miR-107 promotes excitatory neurotoxicity through down-regulation of glutamate transporter-1 expression following ischaemic stroke. -other hsa-mir-1 "Diabetes Mellitus, Type 2" 24944010 "Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4). " -other hsa-mir-103 "Diabetes Mellitus, Type 2" 24944010 "Insulin resistance, obesity, and hyperlipidemia (high lipid levels in the blood) have a strong connection with T2D and several miRNAs influence these clinical outcomes such as miR-143, miR-103, and miR-107, miR-29a, and miR-27b." -other hsa-mir-107 "Diabetes Mellitus, Type 2" 24944010 "Insulin resistance, obesity, and hyperlipidemia (high lipid levels in the blood) have a strong connection with T2D and several miRNAs influence these clinical outcomes such as miR-143, miR-103, and miR-107, miR-29a, and miR-27b." -other hsa-mir-124a "Diabetes Mellitus, Type 2" 24944010 "The influence of miRNAs (miR-7, miR-124a, miR-9, miR-96, miR-15a/b, miR-34a, miR-195, miR-376, miR-103, miR-107, and miR-146) in insulin secretion and beta (β) cell development has been well discussed." -other hsa-mir-126 "Diabetes Mellitus, Type 2" 24944010 "Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4). " -other hsa-mir-128a "Diabetes Mellitus, Type 2" 24944010 "Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4). " -other hsa-mir-133a "Diabetes Mellitus, Type 2" 24944010 "Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4)." -other hsa-mir-133b "Diabetes Mellitus, Type 2" 24944010 "Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4)." -other hsa-mir-143 "Diabetes Mellitus, Type 2" 24944010 "Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4)." -other hsa-mir-145 "Diabetes Mellitus, Type 2" 24944010 "Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4)." -other hsa-mir-146 "Diabetes Mellitus, Type 2" 24944010 "The influence of miRNAs (miR-7, miR-124a, miR-9, miR-96, miR-15a/b, miR-34a, miR-195, miR-376, miR-103, miR-107, and miR-146) in insulin secretion and beta (β) cell development has been well discussed." -other hsa-mir-15a "Diabetes Mellitus, Type 2" 24944010 "The influence of miRNAs (miR-7, miR-124a, miR-9, miR-96, miR-15a/b, miR-34a, miR-195, miR-376, miR-103, miR-107, and miR-146) in insulin secretion and beta (β) cell development has been well discussed." -other hsa-mir-15b "Diabetes Mellitus, Type 2" 24944010 "The influence of miRNAs (miR-7, miR-124a, miR-9, miR-96, miR-15a/b, miR-34a, miR-195, miR-376, miR-103, miR-107, and miR-146) in insulin secretion and beta (β) cell development has been well discussed." -other hsa-mir-181b "Diabetes Mellitus, Type 2" 24944010 "Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4)." -other hsa-mir-195 "Diabetes Mellitus, Type 2" 24944010 "The influence of miRNAs (miR-7, miR-124a, miR-9, miR-96, miR-15a/b, miR-34a, miR-195, miR-376, miR-103, miR-107, and miR-146) in insulin secretion and beta (β) cell development has been well discussed." -other hsa-mir-21 "Diabetes Mellitus, Type 2" 24944010 "Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4)." -other hsa-mir-223 "Diabetes Mellitus, Type 2" 24944010 "Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4)." -other hsa-mir-27b "Diabetes Mellitus, Type 2" 24944010 "Insulin resistance, obesity, and hyperlipidemia (high lipid levels in the blood) have a strong connection with T2D and several miRNAs influence these clinical outcomes such as miR-143, miR-103, and miR-107, miR-29a, and miR-27b" -other hsa-mir-29 "Diabetes Mellitus, Type 2" 24944010 "Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4)." -other hsa-mir-29a "Diabetes Mellitus, Type 2" 24944010 "Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4)." -other hsa-mir-320 "Diabetes Mellitus, Type 2" 24944010 "Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4)." -other hsa-mir-33a "Diabetes Mellitus, Type 2" 24944010 "Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4)." -other hsa-mir-33b "Diabetes Mellitus, Type 2" 24944010 "Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4)." -other hsa-mir-34a "Diabetes Mellitus, Type 2" 24944010 "The influence of miRNAs (miR-7, miR-124a, miR-9, miR-96, miR-15a/b, miR-34a, miR-195, miR-376, miR-103, miR-107, and miR-146) in insulin secretion and beta (β) cell development has been well discussed." -other hsa-mir-376 "Diabetes Mellitus, Type 2" 24944010 "The influence of miRNAs (miR-7, miR-124a, miR-9, miR-96, miR-15a/b, miR-34a, miR-195, miR-376, miR-103, miR-107, and miR-146) in insulin secretion and beta (β) cell development has been well discussed." -other hsa-mir-383 "Diabetes Mellitus, Type 2" 24944010 "Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4)." -other hsa-mir-384 "Diabetes Mellitus, Type 2" 24944010 "Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4)." -other hsa-mir-7 "Diabetes Mellitus, Type 2" 24944010 "The influence of miRNAs (miR-7, miR-124a, miR-9, miR-96, miR-15a/b, miR-34a, miR-195, miR-376, miR-103, miR-107, and miR-146) in insulin secretion and beta (β) cell development has been well discussed." -other hsa-mir-9 "Diabetes Mellitus, Type 2" 24944010 "The influence of miRNAs (miR-7, miR-124a, miR-9, miR-96, miR-15a/b, miR-34a, miR-195, miR-376, miR-103, miR-107, and miR-146) in insulin secretion and beta (β) cell development has been well discussed." -other hsa-mir-96 "Diabetes Mellitus, Type 2" 24944010 "The influence of miRNAs (miR-7, miR-124a, miR-9, miR-96, miR-15a/b, miR-34a, miR-195, miR-376, miR-103, miR-107, and miR-146) in insulin secretion and beta (β) cell development has been well discussed." -other hsa-mir-146b "Carcinoma, Thyroid" 24946010 The roles of the epithelial-mesenchymal transition marker PRRX1 and miR-146b-5p in papillary thyroid carcinoma progression. -other hsa-mir-29c Bladder Neoplasms 24952510 Down-regulation of miR-29c in human bladder cancer and the inhibition of proliferation in T24 cell via PI3K-AKT pathway. -other hsa-mir-33 Atherosclerosis 24953492 "Taken together, these results reveal that C. pneumoniae may negatively regulate ABCA1 expression via TLR2-NF-¦ÊB and miR-33 pathways in THP-1 macrophage-derived foam cells, which may provide new insights for understandingthe effects of C. pneumoniae on the pathogenesis of atherosclerosis." -other hsa-mir-29c Influenza 24953694 Induction of the cellular miR-29c by influenza virus inhibits the innate immune response through protection of A20 mRNA. -other hsa-mir-130a "Carcinoma, Gallbladder" 24953832 "Together, these results suggest that HOTAIR is a c-Myc-activated driver of malignancy, which acts in part through repression of miRNA-130a." -other hsa-mir-124 Glioblastoma 24954504 MicroRNA-124 expression counteracts pro-survival stress responses in glioblastoma. -other hsa-mir-222 "Carcinoma, Lung, Non-Small-Cell" 24955421 MicroRNA-222 expression and its prognostic potential in non-small cell lung cancer. -other hsa-mir-199a Osteosarcoma 24957404 MicroRNA-199a-3p and microRNA-34a regulate apoptosis in human osteosarcoma cells. -other hsa-mir-34a Osteosarcoma 24957404 MicroRNA-199a-3p and microRNA-34a regulate apoptosis in human osteosarcoma cells. -other hsa-mir-101 Lung Neoplasms 24958470 IL-1¦Â-mediated repression of microRNA-101 is crucial for inflammation-promoted lung tumorigenesis. -other hsa-mir-126 Chronic Heart Failure 24958738 "In conclusion, the present study shows that HDL isolated from CHF patients (NYHA-III) reduces the expression of pro-angiogenic miRs (i.e. miR-126 and miR-21), which may contribute to atherogenesis and endothelial dysfunction. However, exercise training was able to attenuate the HDL-induced reduction in pro-angiogenic miRs expression." -other hsa-mir-21 Chronic Heart Failure 24958738 "In conclusion, the present study shows that HDL isolated from CHF patients (NYHA-III) reduces the expression of pro-angiogenic miRs (i.e. miR-126 and miR-21), which may contribute to atherogenesis and endothelial dysfunction. However, exercise training was able to attenuate the HDL-induced reduction in pro-angiogenic miRs expression." -other hsa-mir-214 Chronic Heart Failure 24958738 "In conclusion, the present study shows that HDL isolated from CHF patients (NYHA-III) reduces the expression of pro-angiogenic miRs (i.e. miR-126 and miR-21), which may contribute to atherogenesis and endothelial dysfunction. However, exercise training was able to attenuate the HDL-induced reduction in pro-angiogenic miRs expression." -other hsa-mir-221 Chronic Heart Failure 24958738 "In conclusion, the present study shows that HDL isolated from CHF patients (NYHA-III) reduces the expression of pro-angiogenic miRs (i.e. miR-126 and miR-21), which may contribute to atherogenesis and endothelial dysfunction. However, exercise training was able to attenuate the HDL-induced reduction in pro-angiogenic miRs expression." -other hsa-mir-222 Chronic Heart Failure 24958738 "In conclusion, the present study shows that HDL isolated from CHF patients (NYHA-III) reduces the expression of pro-angiogenic miRs (i.e. miR-126 and miR-21), which may contribute to atherogenesis and endothelial dysfunction. However, exercise training was able to attenuate the HDL-induced reduction in pro-angiogenic miRs expression." -other hsa-mir-21 Human Immunodeficiency Virus Infection 24961346 Relevance of miR-21 in HIV and non-HIV-related lymphomas. -other hsa-mir-145 "Carcinoma, Gallbladder" 24966896 miR-1 and miR-145 act as tumor suppressor microRNAs in gallbladder cancer. -other hsa-mir-200 Ovarian Neoplasms 24966949 Clinicopathological and prognostic implications of the miR-200 family in patients with epithelial ovarian cancer. -other hsa-mir-200 Breast Neoplasms 24967704 The tetraindole SK228 reverses the epithelial-to-mesenchymal transition of breast cancer cells by up-regulating members of the miR-200 family. -other hsa-mir-424 Neoplasms [unspecific] 24967963 Hypoxia-induced miR-424 decreases tumor sensitivity to chemotherapy by inhibiting apoptosis. -other hsa-mir-20a Neoplasms [unspecific] 24969314 "Furthermore, we demonstrated that upregulation of the miR-17-92 cluster (miR-20a/miR-17-5p) is involved in the regulation of E2F1-mediated negative feedback of the c-Myc/hTERT pathway." -other hsa-mir-31 Medulloblastoma 24970811 MicroRNA-31 suppresses medulloblastoma cell growth by inhibiting DNA replication through minichromosome maintenance 2. -other hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 24971479 Role of miR-15/16 in CLL. -other hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 24971479 Role of miR-15/16 in CLL. -other hsa-mir-124 Osteosarcoma 24971902 The tumor suppressor role of miR-124 in osteosarcoma. -other hsa-mir-630 Prostate Neoplasms 24971999 Gefitinib and luteolin cause growth arrest of human prostate cancer PC-3 cells via inhibition of cyclin G-associated kinase and induction of miR-630. -other hsa-mir-122 "Fatty Liver, Non-Alcoholic" 24973316 miR-122 plays a role of physiological significance in the biology of NAFLD; circulating miRNAs mirror the histological and molecular events occurring in the liver. NAFLD has a distinguishing circulating miRNA profile associated with a global dysmetabolic disease state and cardiovascular risk. -other hsa-mir-142 Glioma 24974128 These data indicate a unique role of miR-142-3p in glioma immunity by modulating M2 macrophages through the transforming growth factor beta signaling pathway. -other hsa-mir-18a "Carcinoma, Hepatocellular" 24975878 Elevated p53 promotes the processing of miR-18a to decrease estrogen receptor-¦Á in female hepatocellular carcinoma. -other hsa-mir-483 Vascular Disease [unspecific] 24976017 Angiotensin II-regulated microRNA 483-3p directly targets multiple components of the renin-angiotensin system. -other hsa-mir-31 Lung Neoplasms 24978700 Allelic imbalance in the miR-31 host gene locus in lung cancer--its potential role in carcinogenesis. -other hsa-mir-21 Breast Malignant Phyllodes Tumor 24980553 miR-21 induces myofibroblast differentiation and promotes the malignant progression of breast phyllodes tumors. -other hsa-mir-21 Multiple Myeloma 24981236 MicroRNA-21 and multiple myeloma: small molecule and big function. -other hsa-mir-630 Colorectal Carcinoma 24981248 MicroRNA-630 is a prognostic marker for patients with colorectal cancer. -other hsa-mir-34a Gastric Neoplasms 24981249 MiRNA-34a inhibits EGFR-signaling-dependent MMP7 activation in gastric cancer. -other hsa-mir-29a "Tuberculosis, Pulmonary" 24981709 Dynamics of T-cell IFN-¦Ã and miR-29a expression during active pulmonary tuberculosis. -other hsa-mir-1 Prostate Neoplasms 24982356 Heat-shock protein HSPB1 attenuates microRNA miR-1 expression thereby restoring oncogenic pathways in prostate cancer cells. -other hsa-mir-23b Breast Neoplasms 24985346 Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells. -other hsa-mir-34a Gastric Neoplasms 24988056 Luteolin Induces Apoptosis by Up-regulating miR-34a in Human Gastric Cancer Cells. -other hsa-mir-17 Synovial Sarcoma 24989082 SS18-SSX-regulated miR-17 promotes tumor growth of synovial sarcoma by inhibiting p21WAF1/CIP1. -other hsa-mir-155 "Lymphoma, Large B-Cell, Diffuse" 24989312 Role of miR-155 in pathogenesis of diffuse large B cell lymphoma and its possible mechanism -other hsa-mir-603 Glioblastoma 24994119 A genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomas. -other hsa-mir-146a Keratitis 24996260 Our data demonstrate that miR-146a controls nuclear factor kappa B-dependent inflammatory responses in keratinocytes and chronic skin inflammation in AD. -other hsa-mir-125b Alzheimer Disease 25001178 MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease. -other hsa-mir-17 Breast Neoplasms 25001613 Systematic analysis of metastasis-associated genes identifies miR-17-5p as a metastatic suppressor of basal-like breast cancer. -other hsa-mir-203 Prostate Neoplasms 25004126 Loss of EGFR signaling regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance. -other hsa-mir-125b Acute Lung Injury 25004393 Enforced expression of miR-125b attenuates LPS-induced acute lung injury. -other hsa-mir-152 Prostate Neoplasms 25004396 MicroRNA profiling of novel African American and Caucasian Prostate Cancer cell lines reveals a reciprocal regulatory relationship of miR-152 and DNA methyltranferase 1. -other hsa-mir-29b Hematologic Neoplasms 25004911 Recent research of miR-29 family in hematological malignancies has proven its oncogenic as well as tumor suppressive potential. -other hsa-mir-125b "Leukemia, Myeloid" 25006123 Dual mechanisms by which miR-125b represses IRF4 to induce myeloid and B-cell leukemias. -other hsa-mir-451 Pulmonary Hypertension 25006399 "In conclusion, transient inhibition of miR-451 attenuated the development of PAH in hypoxia-exposed rats." -other hsa-mir-204 Pulmonary Hypertension 25006436 "Novel research shows that miR-204, a microRNA recently found to be notably downregulated through induction of PARP-1 (poly [ADP-ribose] polymerase 1) by excessive DNA damage in PAH, inhibits activation of STAT3." -other hsa-mir-221 Breast Neoplasms 25007959 Exosomal miR-221/222 enhances tamoxifen resistance in recipient ER-positive breast cancer cells. -other hsa-mir-222 Breast Neoplasms 25007959 Exosomal miR-221/222 enhances tamoxifen resistance in recipient ER-positive breast cancer cells. -other hsa-mir-17 "Carcinoma, Renal Cell" 25011053 miR-17 inhibition enhances the formation of kidney cancer spheres with stem cell/tumor initiating cell properties. -other hsa-mir-101 Osteosarcoma 25013866 miR-101 blocks autophagy during the chemotherapy in osteosarcoma cells and enhances chemosensitivity in vitro. -other hsa-mir-34a Ewing Sarcoma 25015333 "By demonstrating its relationship with clinical outcome, we propose evaluation of miR-34a at diagnosis of EWS patients to allow early risk stratification. Validation of these results would nonetheless ultimately need a prospective assessment." -other hsa-mir-29a Osteosarcoma 25015394 Prognostic value of the microRNA-29 family in patients with primary osteosarcomas. -other hsa-mir-29b Osteosarcoma 25015394 Prognostic value of the microRNA-29 family in patients with primary osteosarcomas. -other hsa-mir-29c Osteosarcoma 25015394 Prognostic value of the microRNA-29 family in patients with primary osteosarcomas. -other hsa-mir-142 Liver Neoplasms 25015418 Regulatory role of miR-142-3p on the functional hepatic cancer stem cell marker CD133. -other hsa-mir-210 Myocardial Infarction 25016614 "MicroRNAs most highly enriched in EVs secreted by CPCs compared with fibroblasts included miR-210, miR-132, and miR-146a-3p." -other hsa-mir-1290 "Carcinoma, Lung, Non-Small-Cell" 25016979 miR-1290 suppresses cell viability and cell cycle progression. These data provide insight into miR-1290-mediated cellular mechanisms in asiatic acid-treated A549 non-small cell lung carcinoma cells. -other hsa-mir-9 Breast Neoplasms 25017439 FOXO1 3'UTR functions as a ceRNA in repressing the metastases of breast cancer cells via regulating miRNA activity. -other hsa-mir-128 Glioblastoma 25017996 miR-128 and miR-149 enhance the chemosensitivity of temozolomide by Rap1B-mediated cytoskeletal remodeling in glioblastoma. -other hsa-mir-149 Glioblastoma 25017996 miR-128 and miR-149 enhance the chemosensitivity of temozolomide by Rap1B-mediated cytoskeletal remodeling in glioblastoma. -other hsa-mir-122 "Carcinoma, Hepatocellular" 25023326 Baculovirus-mediated miRNA regulation to suppress hepatocellular carcinoma tumorigenicity and metastasis. -other hsa-mir-451 "Adenocarcinoma, Lung" 25026294 Acquisition of radioresistance in docetaxel-resistant human lung adenocarcinoma cells is linked with dysregulation of miR-451/c-Myc-survivin/rad-51 signaling. -other hsa-mir-302c "Carcinoma, Hepatocellular" 25027009 MiR-302c inhibits tumor growth of hepatocellular carcinoma by suppressing the endothelial-mesenchymal transition of endothelial cells. -other hsa-let-7 Epstein-Barr Virus Infection 25031339 Epstein-Barr virus EBNA1 protein regulates viral latency through effects on let-7 microRNA and dicer. -other hsa-mir-193b "Carcinoma, Hepatocellular" 25034398 Modulation of miRNAs expression might be a potential way to enhance response to sorafenib in HBV-associated HCC. -other hsa-mir-223 Gastric Neoplasms 25036956 Increased microRNA-223 in Helicobacter pylori-associated gastric cancer contributed to cancer cell proliferation and migration. -other hsa-mir-122 Liver Injury 25039534 "In mice and humans, miR-122 levels represent an independent and potent marker of ongoing liver injury and hepatic cell death regardless of the underlying disease." -other hsa-mir-340 Melanoma 25043973 MicroRNA-340 as a modulator of RAS-RAF-MAPK signaling in melanoma. -other hsa-mir-99a "Carcinoma, Lung, Non-Small-Cell" 25046358 A novel small-molecule compound diaporine A inhibits non-small cell lung cancer growth by regulating miR-99a/mTOR signaling. -other hsa-mir-941 "Carcinoma, Hepatocellular" 25049231 miR-941 and KDM6B regulated the epithelial-mesenchymal transition process and affected cell migratory/invasive properties. -other hsa-mir-21 Neoplasms [unspecific] 25049417 "PAPD5 and PARN mediate degradation of oncogenic miRNA miR-21 through a tailing and trimming process, and that this pathway is disrupted in cancer and other proliferative diseases." -other hsa-mir-133a Breast Neoplasms 25051376 both miR-148b and miR-133a have potential use as biomarkers for breast cancer detection -other hsa-mir-148b Breast Neoplasms 25051376 both miR-148b and miR-133a have potential use as biomarkers for breast cancer detection -other hsa-mir-34a Neoplasms [unspecific] 25052958 The well-formulated LPEI-CaPs with lc-miRNA-d have the potential to provide superior miRNA transfection efficiency and inhibition of cancer proliferation. -other hsa-mir-146a Osteoarthritis 25052989 "The mechanism underlying the inhibitory effects of denbinobin involved miR-146a induction, which in turn inhibited NF-κB signaling." -other hsa-mir-34a Prostate Neoplasms 25053345 "This study supports the extracellular environment as an important source of minimally invasive predictive biomarkers representing their cellular origin. Using miR-34a as example, we showed that biomarkers identified in this manner may also hold functional relevance." -other hsa-mir-150 Melanoma 25054912 Role of microRNA-150 and glycoprotein nonmetastatic melanoma protein B in angiogenesis during hyperoxia-induced neonatal lung injury. -other hsa-mir-200c Glioblastoma 25058589 Correlation between EGFR amplification and the expression of microRNA-200c in primary glioblastoma multiforme. -other hsa-mir-101 Breast Neoplasms 25059472 miR-101 promotes breast cancer cell apoptosis by targeting Janus kinase 2. -other hsa-mir-186 Diabetes Mellitus 25059983 Differentiation of human induced pluripotent stem cells into insulin-like cell clusters with miR-186 and miR-375 by using chemical transfection. -other hsa-mir-375 Diabetes Mellitus 25059983 Differentiation of human induced pluripotent stem cells into insulin-like cell clusters with miR-186 and miR-375 by using chemical transfection. -other hsa-mir-144 Ischemic Diseases [unspecific] 25060662 MicroRNA-144 is a circulating effector of remote ischemic preconditioning. -other hsa-mir-21 "Adenocarcinoma, Pancreatic Ductal" 25061297 "microRNAs miR-21, miR-221, miR-222, and miR-10 in PDCA cells, promoting an almost complete abolishment of microRNA expression. " -other hsa-mir-221 "Adenocarcinoma, Pancreatic Ductal" 25061297 "microRNAs miR-21, miR-221, miR-222, and miR-10 in PDCA cells, promoting an almost complete abolishment of microRNA expression. " -other hsa-mir-222 "Adenocarcinoma, Pancreatic Ductal" 25061297 "microRNAs miR-21, miR-221, miR-222, and miR-10 in PDCA cells, promoting an almost complete abolishment of microRNA expression. " -other hsa-mir-148a Breast Neoplasms 25063027 our findings offer important new insights into the ability of estrogenic GPER signaling to trigger HLA-G expression through inhibiting miR-148a that supports immune evasion in breast cancer. -other hsa-mir-26b Posterior Capsule Opacification 25063219 "MiRNA-26b inhibits the proliferation, migration, and epithelial-mesenchymal transition of lens epithelial cells." -other hsa-mir-34c Breast Neoplasms 25064703 "Together, our results support the role of miR-34c as a tumor suppressor miRNA also in breast cancer." -other hsa-mir-409 Prostate Neoplasms 25065597 Stromal fibroblast-derived miR-409 promotes epithelial-to-mesenchymal transition and prostate tumorigenesis. -other hsa-mir-26 Cardiovascular Diseases [unspecific] 25066487 An emerging role for the miR-26 family in cardiovascular disease. -other hsa-mir-34a Liver Cirrhosis 25068403 "This study demonstrates for the first time, that miRNA-34a mayoriginate to a large extent from the liver. Even though higher levels ofmiRNA-34a are possibly associated with better survival at long-term follow-up in cirrhotic patients with severe portal hypertension receiving TIPS, classical prognostic parameters predict the survival better." -other hsa-mir-100 Urinary Bladder Cancer 25071007 microRNAs-99a/100 mediate a direct relationship between FGFR3 and FOXA1 and potentially facilitate cross talk between these pathways in UCC. -other hsa-mir-99a Urinary Bladder Cancer 25071007 microRNAs-99a/100 mediate a direct relationship between FGFR3 and FOXA1 and potentially facilitate cross talk between these pathways in UCC. -other hsa-mir-146a Myelodysplastic Syndromes 25071842 "miR-146a is also implicated in the pathogenesis of human myelodysplastic syndromes (MDSs) as it is located within a commonly deleted region on chromosome 5, and miR-146a-deficient mice exhibit features of an MDS-like disease." -other hsa-mir-122 Breast Neoplasms 25078559 Neoadjuvant Chemotherapy in Breast Cancer Patients Induces miR-34a and miR-122 Expression. -other hsa-mir-34a Breast Neoplasms 25078559 Neoadjuvant Chemotherapy in Breast Cancer Patients Induces miR-34a and miR-122 Expression. -other hsa-mir-216b Breast Neoplasms 25078617 Regulation of the P2X7R by microRNA-216b in human breast cancer. -other hsa-mir-146a Gastric Neoplasms 25081668 MicroRNA-146a enhances Helicobacter pylori induced cell apoptosis in human gastric cancer epithelial cells. -other hsa-mir-487b Ischemic Diseases [unspecific] 25085941 The 14q32 microRNA gene cluster is highly involved in neovascularization. -other hsa-mir-494 Ischemic Diseases [unspecific] 25085941 The 14q32 microRNA gene cluster is highly involved in neovascularization. -other hsa-mir-495 Ischemic Diseases [unspecific] 25085941 The 14q32 microRNA gene cluster is highly involved in neovascularization. -other hsa-mir-155 Breast Neoplasms 25086633 "MicroRNA-9 is associated with epithelial-mesenchymal transition, breast cancer stem cell phenotype, and tumor progression in breast cancer." -other hsa-mir-200 Breast Neoplasms 25086633 "MicroRNA-9 is associated with epithelial-mesenchymal transition, breast cancer stem cell phenotype, and tumor progression in breast cancer." -other hsa-mir-9 Breast Neoplasms 25086633 "MicroRNA-9 is associated with epithelial-mesenchymal transition, breast cancer stem cell phenotype, and tumor progression in breast cancer." -other hsa-mir-210 Prostate Neoplasms 25091736 Senescent stroma promotes prostate cancer progression: the role of miR-210. -other hsa-mir-106b Renal Fibrosis 25094038 Expression of miR-106b-25 induced by salvianolic acid B inhibits epithelial-to-mesenchymal transition in HK-2 cells. -other hsa-mir-152 "Carcinoma, Laryngeal" 25095980 Expression and clinical significance of microRNA-152 in supragalottic laryngeal carcinoma. -other hsa-mir-508 "Squamous Cell Carcinoma, Esophageal" 25099196 miR-508 sustains phosphoinositide signalling and promotes aggressive phenotype of oesophageal squamous cell carcinoma. -other hsa-mir-146a Graves Ophthalmopathy 25100151 Circulating levels of miR-146a and IL-17 are significantly correlated with the clinical activity of Graves' ophthalmopathy. -other hsa-mir-34 Neoplasms [unspecific] 25102298 Role of microRNA-34 family in cancer with particular reference to cancer angiogenesis. -other hsa-mir-15 Cardiomegaly 25103110 We identified the miR-15 family as a novel regulator of cardiac hypertrophy and fibrosis acting by inhibition of the TGF¦Â-pathway. -other hsa-mir-133a Colorectal Carcinoma 25104873 The clinicopathological significance of miR-133a in colorectal cancer. -other hsa-mir-196a Focal Segmental Glomerulosclerosis 25107948 "The levels of urinary miR-196a, miR-30a-5p, and miR-490 are associated with FSGS disease activity." -other hsa-mir-30a Focal Segmental Glomerulosclerosis 25107948 "The levels of urinary miR-196a, miR-30a-5p, and miR-490 are associated with FSGS disease activity." -other hsa-mir-490 Focal Segmental Glomerulosclerosis 25107948 "The levels of urinary miR-196a, miR-30a-5p, and miR-490 are associated with FSGS disease activity." -other hsa-mir-100 "Squamous Cell Carcinoma, Esophageal" 25109390 MicroRNA-100 promotes migration and invasion through mammalian target of rapamycin in esophageal squamous cell carcinoma. -other hsa-mir-101 Bladder Neoplasms 25109742 Enforced expression of miR-101 enhances cisplatin sensitivity in human bladder cancer cells by modulating the cyclooxygenase-2 pathway. -other hsa-mir-218 "Carcinoma, Hepatocellular" 25110121 Prognostic significance of miR-218 in human hepatocellular carcinoma and its role in cell growth. -other hsa-mir-497 Acute Myocardial Infarction 25110754 High association between human circulating microRNA-497 and acute myocardial infarction. -other hsa-mir-499 Myocardial Infarction 25111390 "Our results demonstrate that circulating miR-499 is a novel, early biomarker for identifying perioperative myocardial infarction in cardiac surgery." -other hsa-mir-665 Heart Failure 25111814 MicroRNA-665 is involved in the regulation of the expression of the cardioprotective cannabinoid receptor CB2 in patients with severe heart failure. -other hsa-mir-124 Prostate Neoplasms 25115393 The miR-124-prolyl hydroxylase P4HA1-MMP1 axis plays a critical role in prostate cancer progression. -other hsa-mir-23b Prostate Neoplasms 25115396 The microRNA-23b/27b/24-1 cluster is a disease progression marker and tumor suppressor in prostate cancer. -other hsa-mir-24-1 Prostate Neoplasms 25115396 The microRNA-23b/27b/24-1 cluster is a disease progression marker and tumor suppressor in prostate cancer. -other hsa-mir-27b Prostate Neoplasms 25115396 The microRNA-23b/27b/24-1 cluster is a disease progression marker and tumor suppressor in prostate cancer. -other hsa-mir-1291 "Carcinoma, Pancreatic" 25115443 N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291-altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis. -other hsa-mir-138 Prostate Neoplasms 25116803 α-solanine downregulates oncogenic microRNA-21 (miR-21) and upregulates tumor suppressor miR-138 expression. -other hsa-mir-21 Prostate Neoplasms 25116803 α-solanine downregulates oncogenic microRNA-21 (miR-21) and upregulates tumor suppressor miR-138 expression. -other hsa-mir-122 "Fatty Liver, Non-Alcoholic" 25117675 Silencing of microRNA-122 is an early event during hepatocarcinogenesis from non-alcoholic steatohepatitis. -other hsa-mir-218 "Carcinoma, Hepatocellular" 25120782 miR-218 modulate hepatocellular carcinoma cell proliferation through PTEN/AKT/PI3K pathway and HoxA10. -other hsa-mir-30e Dengue Virus Infection 25122182 MicroRNA-30e* suppresses dengue virus replication by promoting NF-¦ÊB-dependent IFN production. -other hsa-mir-181b Pancreatic Neoplasms 25126577 "Some miRNAs were found to be specifically expressed in some ZHENGs, for instance, miR-17, miR-21, and miR-181b in Shi-Re ZHENG and miR-196a in Pi-Xu ZHENG." -other hsa-mir-1290 Prostate Neoplasms 25129854 Exosomal miR-1290 and miR-375 as prognostic markers in castration-resistant prostate cancer. -other hsa-mir-375 Prostate Neoplasms 25129854 Exosomal miR-1290 and miR-375 as prognostic markers in castration-resistant prostate cancer. -other hsa-mir-17 Leukemia 25130806 Anti-leukemia mechanism of miR-17 and miR-20a silencing mediated by miRNA sponge. -other hsa-mir-20a Leukemia 25130806 Anti-leukemia mechanism of miR-17 and miR-20a silencing mediated by miRNA sponge. -other hsa-mir-192 Cholangiocarcinoma 25131257 This finding indicates that elevated levels of miR-192 may be involved in CCA genesis and have a potential utility as a noninvasive prognostic indicator for CCA patients. -other hsa-mir-541 Prostate Neoplasms 25135278 Infiltrating T cells promote prostate cancer metastasis via modulation of FGF11¡úmiRNA-541¡úandrogen receptor (AR)¡úMMP9 signaling. -other hsa-mir-31 Neoplasms [unspecific] 25139099 Prognostic role of microRNA-31 in various cancers: a meta-analysis. -other hsa-mir-24 Osteosarcoma 25142229 Nucleotidyl transferase TUT1 inhibits lipogenesis in osteosarcoma cells through regulation of microRNA-24 and microRNA-29a. -other hsa-mir-29a Osteosarcoma 25142229 Nucleotidyl transferase TUT1 inhibits lipogenesis in osteosarcoma cells through regulation of microRNA-24 and microRNA-29a. -other hsa-mir-29a Cardiomegaly 25145535 MicroRNA-29a is a friend or foe for cardiac hypertrophy -other hsa-mir-618 Thyroid Neoplasms 25145559 MiR-618 inhibits anaplastic thyroid cancer by repressing XIAP in one ATC cell line. -other hsa-mir-21 Kidney Injury 25145934 MicroRNA-21 in glomerular injury. -other hsa-mir-15 Salmonellosis 25146723 Functional high-throughput screening identifies the miR-15 microRNA family as cellular restriction factors for Salmonella infection. -other hsa-mir-133a Muscle Diseases [unspecific] 25146754 These miRNAs are potential biomarkers of muscle damage or adaptation to exercise. -other hsa-mir-206 Muscle Diseases [unspecific] 25146754 These miRNAs are potential biomarkers of muscle damage or adaptation to exercise. -other hsa-mir-21 Neoplasms [unspecific] 25149066 miR-21-3p is a positive regulator of L1CAM in several human carcinomas. -other hsa-mir-7 Glioblastoma 25149532 Systemic miRNA-7 delivery inhibits tumor angiogenesis and growth in murine xenograft glioblastoma. -other hsa-mir-30a Neuroblastoma 25149854 Lithium/Valproic acid combination and L-glutamate induce similar pattern of changes in the expression of miR-30a-5p in SH-SY5Y neuroblastoma cells. -other hsa-mir-122 Breast Neoplasms 25150312 Breast cancer-specific TRAIL expression mediated by miRNA response elements of let-7 and miR-122. -other hsa-mir-451 Lung Neoplasms 25150396 MiR-451 suppresses cell proliferation and metastasis in A549 lung cancer cells. -other hsa-mir-130b Ovarian Neoplasms 25155039 MicroRNA 130b enhances drug resistance in human ovarian cancer cells. -other hsa-mir-125b "Carcinoma, Renal Cell, Clear-Cell" 25155155 Tumor miR-125b predicts recurrence and survival of patients with clear-cell renal cell carcinoma after surgical resection. -other hsa-mir-378 Aortic Stenosis 25157568 "Circulating levels of miR-1, miR-133 and miR-378 were decreased in AS patients, and miR-378 predicts LVH independent of the pressure gradient. Further prospective investigations are needed to elucidate whether these circulating miRs affect clinical outcome." -other hsa-mir-21 Ischemia-Reperfusion Injury 25159851 miR-21 in ischemia/reperfusion injury: a double-edged sword -other hsa-mir-106b Bladder Neoplasms 25168920 Urinary cell-free microRNA-106b as a novel biomarker for detection of bladder cancer. -other hsa-mir-520h Neoplasms [unspecific] 25169894 "PD-miRNAs that are currently implicated as cancer biomarkers or diagnostics: hsa-mir-202, hsa-mir-423, hsa-mir-196a-2, hsa-mir-520h, hsa-mir-647, hsa-mir-943, and hsa-mir-1908." -other hsa-mir-29 Breast Neoplasms 25174825 Aberrant miR-29 expression may account for reduced NMI expression in breast tumors and mesenchymal phenotype of cancer cells that promotes invasive growth. Reduction in NMI levels has a feed-forward impact on miR-29 levels. -other hsa-mir-29b-1 Osteosarcoma 25174983 "MicroRNA-29b-1 impairs in vitro cell proliferation, self-renewal and chemoresistance of human osteosarcoma 3AB-OS cancer stem cells." -other hsa-mir-124a Glioma 25175832 miR-124a restoration inhibits glioma cell proliferation and invasion by suppressing IQGAP1 and ¦Â-catenin. -other hsa-mir-21 "Squamous Cell Carcinoma, Head and Neck" 25175929 miR-21 increases the programmed cell death 4 gene-regulated cell proliferation in head and neck squamous carcinoma cell lines. -other hsa-mir-1 Heart Diseases [unspecific] 25177824 miRNA-1: functional roles and dysregulation in heart disease. -other hsa-mir-21 Colorectal Carcinoma 25178983 "Circulating miR21 level has potential value for colorectal cancer early detection, whereas high tissue miR21 level is associated with adverse colorectal cancer prognosis." -other hsa-mir-152 "Carcinoma, Lung, Non-Small-Cell" 25190353 MiR-152 suppresses the proliferation and invasion of NSCLC cells by inhibiting FGF2. -other hsa-mir-122 "Carcinoma, Ovarian" 25195148 A polymorphism at miRNA-122-binding site in the IL-1¦Á 3'UTR is associated with risk of epithelial ovarian cancer. -other hsa-mir-375 Neoplasms [unspecific] 25195536 "The CMAP database is a useful tool for identifying compounds affecting the same molecular pathways, particularly products that are difficult to apply via practical approaches, such as microRNAs." -other hsa-mir-1280 Melanoma 25195599 Antitumor activity of miR-1280 in melanoma by regulation of Src. -other hsa-mir-1 Colorectal Carcinoma 25196260 Tumor suppressor miR-1 restrains epithelial-mesenchymal transition and metastasis of colorectal carcinoma via the MAPK and PI3K/AKT pathway. -other hsa-mir-107 Colorectal Carcinoma 25197016 MiR-107 and miR-99a-3p were validated as predictors of response to standard fluoropyrimidine-based chemotherapy in patients with mCRC. -other hsa-mir-99a Colorectal Carcinoma 25197016 MiR-107 and miR-99a-3p were validated as predictors of response to standard fluoropyrimidine-based chemotherapy in patients with mCRC. -other hsa-mir-126 "Carcinoma, Colon" 25199818 The current population based study of patients operated for stage II colon cancer demonstrated correlations between several prognostic unfavourable characteristics and miRNA-126 and argues for a possible prognostic impact on overall survival. An influence on survival by the MVD estimate was not detected. -other hsa-mir-195 Aortic Aneurysm 25201911 "We provide the first evidence that miR-195 may contribute to the pathogenesis of aortic aneurysmal disease. Although inhibition of miR-29b proved more effective in preventing aneurysm formation in a preclinical model, miR-195represents a potent regulator of the aortic extracellular matrix. Notably, plasma levels of miR-195 were reduced in patients with abdominal aortic aneurysms suggesting that microRNAs might serve as a noninvasive biomarker of abdominal aortic aneurysms." -other hsa-mir-33a Glioma 25202981 miR-33a promotes glioma-initiating cell self-renewal via PKA and NOTCH pathways. -other hsa-mir-200a Liver Neoplasms 25203708 MiR-200a may play an important role in liver cancer development and may have diagnostic value for indicating early liver cancer. -other hsa-mir-21 Periodontal Diseases 25203845 microRNA-21 mediates stretch-induced osteogenic differentiation in human periodontal ligament stem cells. -other hsa-let-7d Glioblastoma 25212824 the current study is the first to demonstrate the effect of FCL on modulation of let-7d expression -other hsa-mir-193b Breast Neoplasms 25213330 Metformin-induced killing of triple-negative breast cancer cells is mediated by reduction in fatty acid synthase via miRNA-193b. -other hsa-mir-25 Heart Failure 25214573 miR-25 in heart failure. -other hsa-mir-185 "Carcinoma, Colon" 25216407 MicroRNA-185 suppresses growth and invasion of colon cancer cells through inhibition of the hypoxia-inducible factor-2¦Á pathway in vitro and in vivo. -other hsa-mir-199 Cholangiocarcinoma 25217977 the cell proliferation and inhibition of tumor suppression mediated by these miRNAs is common to both cancerous and non-cancerous cells. -other hsa-mir-22 Cardiovascular Diseases [unspecific] 25218673 miR-22 in cardiac remodeling and disease. -other hsa-mir-1246 Ebola Hemorrhagic Fever 25218824 "Hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p inhibitors can reduce the cytotoxicity of Ebola virus glycoprotein in vitro." -other hsa-mir-133b Parkinson Disease 25218846 Our observations suggest that miR-133b might be involved in ceruloplasmin dysmetabolism in PD patients and a further investigation is warranted to confirm this hypothesis. -other hsa-mir-34a Neoplasms [unspecific] 25220161 Dual drugs (microRNA-34a and paclitaxel)-loaded functional solid lipid nanoparticles for synergistic cancer cell suppression. -other hsa-mir-214 Neoplasms [unspecific] 25223704 Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth. -other hsa-mir-494 Lung Neoplasms 25226615 Overexpression of secretagogin inhibits cell apoptosis and induces chemoresistance in small cell lung cancer under the regulation of miR-494. -other hsa-mir-143 Osteosarcoma 25227664 MiR-143 inhibits EGFR-signaling-dependent osteosarcoma invasion. -other hsa-mir-34b Neoplasms [unspecific] 25227823 Association between a polymorphism in miR-34b/c and susceptibility to cancer--a meta-analysis. -other hsa-mir-34c Neoplasms [unspecific] 25227823 Association between a polymorphism in miR-34b/c and susceptibility to cancer--a meta-analysis. -other hsa-mir-155 Lung Neoplasms 25230125 Chitosan combined with molecular beacon for mir-155 detection and imaging in lung cancer. -other hsa-mir-34a "Carcinoma, Nasopharyngeal" 25231528 Hypofractionated radiotherapy induces miR-34a expression and enhances apoptosis in human nasopharyngeal carcinoma cells. -other hsa-mir-137 Glioblastoma 25232498 "OLE significantly induced the expression of miR-153, miR-145, and miR-137 and decreased the expression of the target genes of these miRNAs in GSCs" -other hsa-mir-145 Glioblastoma 25232498 "OLE significantly induced the expression of miR-153, miR-145, and miR-137 and decreased the expression of the target genes of these miRNAs in GSCs" -other hsa-mir-18a Colorectal Carcinoma 25233396 Stool-based miR-221 can be used as a non-invasive biomarker for the detection of CRC. -other hsa-mir-221 Colorectal Carcinoma 25233396 Stool-based miR-221 can be used as a non-invasive biomarker for the detection of CRC. -other hsa-mir-217 Lung Neoplasms 25234467 MicroRNA-217 functions as a tumour suppressor gene and correlates with cell resistance to cisplatin in lung cancer. -other hsa-mir-21 "Squamous Cell Carcinoma, Oral" 25236707 Human papillomavirus-stratified analysis of the prognostic role of miR-21 in oral cavity and oropharyngeal squamous cell carcinoma. -other hsa-mir-451a Melanoma 25237911 "A novel miR-451a isomiR, associated with amelanotypic phenotype, acts as a tumor suppressor in melanoma by retarding cell migration and invasion." -other hsa-mir-93 Breast Neoplasms 25238878 Identification of microRNA-93 as a functional dysregulated miRNA in triple-negative breast cancer. -other hsa-mir-92a Acute Myocardial Infarction 25240056 Early single intracoronary administration of encapsulated antagomir-92a in an adult pig model of reperfused AMI prevents left ventricular remodeling with no local or distant adverse effects -other hsa-mir-16 Glioma 25242314 MicroRNA-16 suppresses epithelial-mesenchymal transition-related gene expression in human glioma. -other hsa-mir-5481 Lung Neoplasms 25245053 These results suggested that miR-548l may play a causal role through AKT1 in NSCLC invasion and metastasis. -other hsa-mir-17 Diabetes Mellitus 25249581 "Ask1 deletion suppressed diabetes-induced IRE1α endoriboneclease activities, which led to X-box binding protein 1 mRNA cleavage, an ER stress marker, decreased expression of microRNAs, and increased expression of a miR-17 target" -other hsa-mir-137 Schizophrenia 25250332 Association of a miRNA-137 polymorphism with schizophrenia in a Southern Chinese Han population. -other hsa-mir-141 "Adenocarcinoma, Prostate" 25252191 "Based on this small pilot study, men with localized prostate cancers with lower miR-221 expression may have a greater risk for recurrence after surgery." -other hsa-mir-21 "Adenocarcinoma, Prostate" 25252191 "Based on this small pilot study, men with localized prostate cancers with lower miR-221 expression may have a greater risk for recurrence after surgery." -other hsa-mir-221 "Adenocarcinoma, Prostate" 25252191 "Based on this small pilot study, men with localized prostate cancers with lower miR-221 expression may have a greater risk for recurrence after surgery." -other hsa-mir-191 Lung Neoplasms 25252218 "MicroRNA-191, by promoting the EMT and increasing CSC-like properties, is involved in neoplastic and metastatic properties of transformed human bronchial epithelial cells." -other hsa-mir-132 Mycobacterium tuberculosis Infection 25252958 Mycobacterium tuberculosis decreases human macrophage IFN-¦Ã responsiveness through miR-132 and miR-26a. -other hsa-mir-26a Mycobacterium tuberculosis Infection 25252958 Mycobacterium tuberculosis decreases human macrophage IFN-¦Ã responsiveness through miR-132 and miR-26a. -other hsa-mir-96 Colorectal Carcinoma 25256312 MiR-96-5p influences cellular growth and is associated with poor survival in colorectal cancer patients. -other hsa-mir-148 Gastric Neoplasms 25261463 Polymorphisms and haplotypes of the miR-148/152 family are associated with the risk and clinicopathological features of gastric cancer in a Northern Chinese population. -other hsa-mir-152 Gastric Neoplasms 25261463 Polymorphisms and haplotypes of the miR-148/152 family are associated with the risk and clinicopathological features of gastric cancer in a Northern Chinese population. -other hsa-mir-210 "Adenocarcinoma, Lung" 25263437 Tissue inhibitor of metalloproteinases-1 induces a pro-tumourigenic increase of miR-210 in lung adenocarcinoma cells and their exosomes. -other hsa-mir-122 Viral Infectious Disease 25265013 MiR-122 directly inhibits human papillomavirus E6 gene and enhances interferon signaling through blocking suppressor of cytokine signaling 1 in SiHa cells. -other hsa-mir-148b Asthma 25266681 "We report that statins upregulate mir-148b and 152, and affect HLA-G expression in an rs1063320-dependent fashion." -other hsa-mir-152 Asthma 25266681 "We report that statins upregulate mir-148b and 152, and affect HLA-G expression in an rs1063320-dependent fashion." -other hsa-mir-21 Bladder Neoplasms 25266796 A lentiviral sponge for miRNA-21 diminishes aerobic glycolysis in bladder cancer T24 cells via the PTEN/PI3K/AKT/mTOR axis. -other hsa-mir-122 "Carcinoma, Hepatocellular" 25269820 MicroRNA sponge blocks the tumor-suppressing functions of microRNA-122 in human hepatoma and osteosarcoma cells. -other hsa-mir-122 Osteosarcoma 25269820 MicroRNA sponge blocks the tumor-suppressing functions of microRNA-122 in human hepatoma and osteosarcoma cells. -other hsa-mir-200 Gastric Neoplasms 25270520 MicroRNA-200 family members and ZEB2 are associated with brain metastasis in gastric adenocarcinoma. -other hsa-mir-34c Ovarian Neoplasms 25273528 Functional analysis of miR-34c as a putative tumor suppressor in high-grade serous ovarian cancer. -other hsa-mir-122 Hepatitis C Virus Infection 25275643 "Exosome-loading with a miR-122 inhibitor, or inhibition of HSP90, vacuolar H+-ATPases, and proton pumps, significantly suppressed exosome-mediated HCV transmission to naïve cells." -other hsa-mir-126 "Carcinoma, Renal Cell" 25279769 "Impact of miR-21, miR-126 and miR-221 as prognostic factors of clear cell renal cell carcinoma with tumor thrombus of the inferior vena cava." -other hsa-mir-21 "Carcinoma, Renal Cell" 25279769 "Impact of miR-21, miR-126 and miR-221 as prognostic factors of clear cell renal cell carcinoma with tumor thrombus of the inferior vena cava." -other hsa-mir-221 "Carcinoma, Renal Cell" 25279769 "Impact of miR-21, miR-126 and miR-221 as prognostic factors of clear cell renal cell carcinoma with tumor thrombus of the inferior vena cava." -other hsa-mir-105 "Carcinoma, Hepatocellular" 25280563 MicroRNA-105 suppresses cell proliferation and inhibits PI3K/AKT signaling in human hepatocellular carcinoma. -other hsa-mir-155 Prostate Neoplasms 25283513 Inhibition of transforming growth factor beta/SMAD signal by MiR-155 is involved in arsenic trioxide-induced anti-angiogenesis in prostate cancer. -other hsa-mir-3127 "Carcinoma, Lung, Non-Small-Cell" 25284075 Reduced miR-3127-5p expression promotes NSCLC proliferation/invasion and contributes to dasatinib sensitivity via the c-Abl/Ras/ERK pathway. -other hsa-mir-203 Squamous Cell Carcinoma 25284788 "Rewiring of an epithelial differentiation factor, miR-203, to inhibit human squamous cell carcinoma metastasis." -other hsa-mir-106b Neoplasms [unspecific] 25286029 miR-106b modulates cancer stem cell characteristics through TGF-¦Â/Smad signaling in CD44-positive gastric cancer cells. -other hsa-mir-495 "Carcinoma, Lung" 25286762 MicroRNA-495 mimics delivery inhibits lung tumor progression. -other hsa-mir-720 Lung Neoplasms 25286763 Evaluation of miR-720 prognostic significance in patients with colorectal cancer. -other hsa-mir-139 Colorectal Carcinoma 25286864 Gene module based regulator inference identifying miR-139 as a tumor suppressor in colorectal cancer. -other hsa-mir-7 "Carcinoma, Lung, Non-Small-Cell" 25289099 Upregulation of miR-7 enhanced the PTX-sensitivity of NSCLC cells by suppressing cell proliferation and promoting cell apoptosis -other hsa-mir-142 "Carcinoma, Hepatocellular" 25292173 This study reveals a novel role for propofol in the inhibition of HCC through MV-mediated transfer of miR-142-3p from macrophages to cancer cells in vivo. -other hsa-mir-204 Colorectal Carcinoma 25294901 Our results demonstrate for the first time that miR-204-5p acts as a tumor suppressor in colorectal cancer through inhibiting RAB22A and reveal RAB22A to be a new oncogene and prognostic factor for colorectal cancer. -other hsa-mir-490 Ovarian Neoplasms 25297343 microRNA 490-3P enhances the drug-resistance of human ovarian cancer cells. -other hsa-mir-212 "Carcinoma, Esophageal" 25299094 Overregulation of microRNA-212 in the poor prognosis of esophageal cancer patients. -other hsa-mir-122 Hepatitis B Virus Infection 25299106 Expression and clinical significance of miR-122 and miR-29 in hepatitis B virus-related liver disease. -other hsa-mir-29 Hepatitis B Virus Infection 25299106 Expression and clinical significance of miR-122 and miR-29 in hepatitis B virus-related liver disease. -other hsa-mir-491 "Carcinoma, Ovarian" 25299770 miR-491-5p-induced apoptosis in ovarian carcinoma depends on the direct inhibition of both BCL-XL and EGFR leading to BIM activation. -other hsa-mir-126 Inflammation 25300227 Polyphenolic extracts from cowpea (Vigna unguiculata) protect colonic myofibroblasts (CCD18Co cells) from lipopolysaccharide (LPS)-induced inflammation--modulation of microRNA 126. -other hsa-mir-30b Heart Failure 25301066 E2F1 transcriptionally represses miR-30b expression. -other hsa-mir-106a Helicobacter pylori Infection 25307786 A MDM2-dependent positive-feedback loop is involved in inhibition of miR-375 and miR-106b induced by Helicobacter pylori lipopolysaccharide. -other hsa-mir-375 Helicobacter pylori Infection 25307786 A MDM2-dependent positive-feedback loop is involved in inhibition of miR-375 and miR-106b induced by Helicobacter pylori lipopolysaccharide. -other hsa-mir-29a Vascular Hypertrophy 25308856 Effect of miR-29a inhibition on ventricular hypertrophy induced by pressure overload. -other hsa-mir-429 "Carcinoma, Hepatocellular, HBV-Related" 25312821 miR-429 represses cell proliferation and induces apoptosis in HBV-related HCC. -other hsa-mir-133a Cardiomegaly 25313674 Our observations supplied the possibility that circulating miR-133a could be a surrogate biomarker of cardiac hypertrophy in MHD patients. -other hsa-mir-126 Atherosclerosis 25315114 "MicroRNAs (miRNAs) encapsulated within microparticles (MPs) are likely to have a role in cell-to-cell signaling in a variety of diseases, including atherosclerosis." -other hsa-mir-21 "Carcinoma, Thyroid" 25316501 The PDCD4/miR-21 pathway in medullary thyroid carcinoma. -other hsa-mir-125b-1 "Leukemia, Myeloid" 25316507 "Myeloid neoplasm with translocation t(2;11)(p21;q23-24), elevated microRNA 125b-1, and JAK2 exon 12 mutation." -other hsa-mir-135a Gastric Neoplasms 25322930 Regulation of BGC-823 cell sensitivity to adriamycin via miRNA-135a-5p. -other hsa-mir-21 Lung Neoplasms 25323306 Effect of microRNA-21 on multidrug resistance reversal in A549/DDP human lung cancer cells. -other hsa-mir-146a Glioblastoma 25326894 The Downregulation of MicroRNA-146a Modulates TGF-¦Â Signaling Pathways Activityin Glioblastoma. -other hsa-mir-106b "Carcinoma, Hepatocellular" 25327652 Effects of miR-106b expression on the proliferation of human hepatocellular carcinoma cells. -other hsa-mir-200a Ovarian Neoplasms 25327865 Involvement of miR-200a in chemosensitivity regulation of ovarian cancer. -other hsa-mir-378 Colorectal Carcinoma 25328987 MicroRNA-378 inhibits cell growth and enhances L-OHP-induced apoptosis in human colorectal cancer. -other hsa-mir-33a Inflammation 25329888 Effects of miR-33a-5P on ABCA1/G1-mediated cholesterol efflux under inflammatory stress in THP-1 macrophages. -other hsa-mir-375 "Carcinoma, Cervical" 25330011 miR-375 mediated acquired chemo-resistance in cervical cancer by facilitating EMT. -other hsa-let-7a Colon Neoplasms 25330373 "63 miRNA are selectively enriched in the EVs--miR-19a/b-3p, miR-378a/c/d, and miR-577 and members of the let-7 and miR-8 families being the most prominent." -other hsa-let-7f Colon Neoplasms 25330373 "63 miRNA are selectively enriched in the EVs--miR-19a/b-3p, miR-378a/c/d, and miR-577 and members of the let-7 and miR-8 families being the most prominent." -other hsa-mir-96 Prostate Neoplasms 25333253 Biphasic regulation of autophagy by miR-96 in prostate cancer cells under hypoxia. -other hsa-mir-573 Breast Neoplasms 25333258 MiR-578 and miR-573 as potential players in BRCA-related breast cancer angiogenesis. -other hsa-mir-578 Breast Neoplasms 25333258 MiR-578 and miR-573 as potential players in BRCA-related breast cancer angiogenesis. -other hsa-mir-34a "Carcinoma, Colon" 25333573 Inhibition of lactate dehydrogenase A by microRNA-34a resensitizes colon cancer cells to 5-fluorouracil. -other hsa-mir-423 "Carcinoma, Laryngeal" 25337209 microRNA-423-3p promotes tumor progression via modulation of AdipoR2 in laryngeal carcinoma. -other hsa-mir-29b Osteosarcoma 25337211 A key role of microRNA-29b in suppression of osteosarcoma cell proliferation and migration via modulation of VEGF. -other hsa-mir-30c Lung Neoplasms 25340791 "Specifically, miR-30c, a FHIT-upregulated microRNA, contributes to FHIT function in suppression of EMT and metastasis" -other hsa-mir-92a Glioma 25342742 We conclude that glioma-derived miR-92a induces IL-6(+) IL-10(+) NKT cells; this fraction of NKT cells can suppress cytotoxic CD8(+) T cells. -other hsa-mir-29b Aortic Aneurysm 25342766 Battle of the bulge: miR-195 versus miR-29b in aortic aneurysm. -other hsa-mir-382 Osteosarcoma 25344865 miR-382 inhibits tumor growth and enhance chemosensitivity in osteosarcoma. -other hsa-mir-9 "Carcinoma, Cervical" 25344913 Activation of miR-9 by human papillomavirus in cervical cancer. -other hsa-mir-126 "Carcinoma, Hepatocellular" 25345948 Expression of miR-126/miR-126* in hepatocelluar carcinoma and its correlation with clinical outcomes. -other hsa-mir-939 "Squamous Cell Carcinoma, Esophageal" 25346128 Expression of microRNA-939 and its correlation with prognosis in esophageal squamous cell carcinoma. -other hsa-mir-23a Neoplasms [unspecific] 25347474 Targeting miR-23a in CD8+ cytotoxic T lymphocytes prevents tumor-dependent immunosuppression. -other hsa-mir-34a Medulloblastoma 25348795 MiR-34a deficiency accelerates medulloblastoma formation in vivo. -other hsa-mir-146a Systemic Lupus Erythematosus 25349113 The miR-146a polymorphism and susceptibility to systemic lupus erythematosus and rheumatoid arthritis : a meta-analysis. -other hsa-mir-132 Nervous System Diseases [unspecific] 25351997 Chronic infection of Toxoplasma gondii downregulates miR-132 expression in multiple brain regions in a sex-dependent manner. -other hsa-mir-24 "Aortic Aneurysm, Abdominal" 25358394 miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development. -other hsa-mir-106b Melanoma 25361006 Down-regulation of miRNA-106b inhibits growth of melanoma cells by promoting G1-phase cell cycle arrest and reactivation of p21/WAF1/Cip1 protein. -other hsa-mir-34a Colorectal Carcinoma 25362853 miR-34a-5p suppresses colorectal cancer metastasis and predicts recurrence in patients with stage II/III colorectal cancer. -other hsa-mir-200c Prostate Neoplasms 25363395 Effects of miR-200c on the migration and invasion abilities of human prostate cancer Du145 cells and the corresponding mechanism. -other hsa-mir-214 Neoplasms [unspecific] 25364765 "By contrast, miR-24, miR-125b, miR-195, and miR-214 function as oncogenic or tumor suppressor miRNAs in a cancer (sub)type-dependent manner." -other hsa-mir-24 Neoplasms [unspecific] 25364765 "By contrast, miR-24, miR-125b, miR-195, and miR-214 function as oncogenic or tumor suppressor miRNAs in a cancer (sub)type-dependent manner." -other hsa-mir-21 "Carcinoma, Ovarian, Clear Cell" 25366985 MicroRNA-21 is a candidate driver gene for 17q23-25 amplification in ovarian clear cell carcinoma. -other hsa-mir-29 "Carcinoma, Hepatocellular" 25367851 Negative feedback of miR-29 family TET1 involves in hepatocellular cancer. -other hsa-mir-509 "Leukemia, Lymphoblastic" 25368993 Regulation of RAB5C is important for the growth inhibitory effects of MiR-509 in human precursor-B acute lymphoblastic leukemia. -other hsa-mir-145 Multiple Myeloma 25369735 Synthetic miR-145 mimic inhibits multiple myeloma cell growth in vitro and in vivo. -other hsa-mir-93 Colorectal Carcinoma 25371073 MicroRNA-93 suppress colorectal cancer development via Wnt/¦Â-catenin pathway downregulating. -other hsa-mir-25 Prostate Neoplasms 25372501 "These effects were strongly associated with changes in reduced expression of the miR-106b cluster (miR-106b, miR-93, and miR-25)" -other hsa-mir-93 Prostate Neoplasms 25372501 "These effects were strongly associated with changes in reduced expression of the miR-106b cluster (miR-106b, miR-93, and miR-25)" -other hsa-mir-1 Glioblastoma 25374033 Targeted delivery of tumor suppressor microRNA-1 by transferrin-conjugated lipopolyplex nanoparticles to patient-derived glioblastoma stem cells. -other hsa-mir-9 Neoplasms [unspecific] 25375090 MicroRNA-9 promotes tumor metastasis via repressing E-cadherin in esophageal squamous cell carcinoma. -other hsa-mir-21 Neoplasms [unspecific] 25376700 MicroRNA-21 and the clinical outcomes of various carcinomas: a systematic review and meta-analysis. -other hsa-mir-18a Colorectal Carcinoma 25379703 miR-18a inhibits CDC42 and plays a tumour suppressor role in colorectal cancer cells. -other hsa-mir-410 Osteosarcoma 25385479 VEGF-mediated suppression of cell proliferation and invasion by miR-410 in osteosarcoma. -other hsa-mir-130b "Carcinoma, Hepatocellular" 25387077 MicroRNA-130b promotes cell aggressiveness by inhibiting peroxisome proliferator-activated receptor gamma in human hepatocellular carcinoma. -other hsa-mir-451 Osteosarcoma 25391425 miR-451 may play an important role in tumor growth and metastasis in osteosarcoma. -other hsa-mir-193a Lung Neoplasms 25391651 our findings provide the first clues regarding the role of miR-193a-3p as a tumor suppressor in lung cancer through the inhibition of ERBB4 translation. -other hsa-mir-107 Kidney Diseases [unspecific] 25392232 "new strategies for probing autonomic circulatory control and ultimately, susceptibility to hypertensive renal sequelae." -other hsa-mir-9 Gastric Neoplasms 25395097 "membranous ALCAM expression and high serum sALCAM levels are independent prognostic markers of poor survival for patients with GC, and that the overexpression of ALCAM may be due to the downregulation of miR-9." -other hsa-mir-34a Atherosclerosis 25395581 miR-34a is involved in the flow-dependent regulation of endothelial inflammation. -other hsa-mir-200 Breast Neoplasms 25401471 metastatic capability can be transferred by the uptake of extracellular vesicles. -other hsa-mir-122 Hepatitis C Virus Infection 25403145 "Our study provides insight into the interaction between miR-122 and HCV, including viral adaptation to reduced miR-122 bioavailability, and has implications for the development of anti-miR-122-based HCV drugs." -other hsa-mir-125b Neoplasms [unspecific] 25403182 these findings illuminate miR-125b as an important microRNA regulator that is shared between normal skin progenitors and their early malignant counterparts. -other hsa-mir-141 Neoplasms [unspecific] 25403569 our comprehensive pan-cancer analysis provided not only biological insights into metastasis but also brought to bear the clinical relevance of the proposed recurrent miRNA-gene associations. -other hsa-mir-200 Neoplasms [unspecific] 25403569 our comprehensive pan-cancer analysis provided not only biological insights into metastasis but also brought to bear the clinical relevance of the proposed recurrent miRNA-gene associations. -other hsa-mir-429 Neoplasms [unspecific] 25403569 our comprehensive pan-cancer analysis provided not only biological insights into metastasis but also brought to bear the clinical relevance of the proposed recurrent miRNA-gene associations. -other hsa-mir-375 "Carcinoma, Esophageal" 25404787 The findings from this meta-analysis suggest that miR-375 expression is associated with OS of patients with malignant tumors and could be a useful clinical prognostic biomarker. -other hsa-mir-23b Bladder Neoplasms 25405368 RNA networks regulated by tumor-suppressive miR-23b/27b provide new insights into the potential mechanisms of BC oncogenesis and metastasis. -other hsa-mir-27b Bladder Neoplasms 25405368 RNA networks regulated by tumor-suppressive miR-23b/27b provide new insights into the potential mechanisms of BC oncogenesis and metastasis. -other hsa-mir-429 Breast Neoplasms 25405387 our results offer an opportunity for further understanding of the recondite mechanisms underlying the bone metastasis of breast cancer. -other hsa-let-7a Cholesteatoma 25405753 reveal the crucial role of let-7a miRNA in the inhibition of growth and invasion of cholesteatoma keratinocytes. -other hsa-mir-21 Cholesteatoma 25405753 reveal the crucial role of let-7a miRNA in the inhibition of growth and invasion of cholesteatoma keratinocytes. -other hsa-let-7f Nervous System Diseases [unspecific] 25406171 EW-induced mitochondrial respiratory suppression was exacerbated by TSA treatment in a manner that was attenuated by let-7f antagomir cotreatment. -other hsa-mir-183 Prostate Neoplasms 25409297 "miRNAs 200b, 30a, 1, and 183 and the genes Twist1 and Vimentin might play important roles in the progression of prostate cancer and may eventually become important prognostic markers." -other hsa-mir-203 Prostate Neoplasms 25409297 "miRNAs 200b, 30a, 1, and 183 and the genes Twist1 and Vimentin might play important roles in the progression of prostate cancer and may eventually become important prognostic markers." -other hsa-mir-205 Prostate Neoplasms 25409297 "miRNAs 200b, 30a, 1, and 183 and the genes Twist1 and Vimentin might play important roles in the progression of prostate cancer and may eventually become important prognostic markers." -other hsa-mir-21 Prostate Neoplasms 25409297 "miRNAs 200b, 30a, 1, and 183 and the genes Twist1 and Vimentin might play important roles in the progression of prostate cancer and may eventually become important prognostic markers." -other hsa-mir-373 Prostate Neoplasms 25409297 "miRNAs 200b, 30a, 1, and 183 and the genes Twist1 and Vimentin might play important roles in the progression of prostate cancer and may eventually become important prognostic markers." -other hsa-mir-204 Mesial Temporal Lobe Epilepsy 25410734 miR-204 and miR-218 are developmentally regulated in the hippocampus and may contribute to the molecular mechanisms underlying the pathogenesis of MTLE and HS. -other hsa-mir-218 Mesial Temporal Lobe Epilepsy 25410734 miR-204 and miR-218 are developmentally regulated in the hippocampus and may contribute to the molecular mechanisms underlying the pathogenesis of MTLE and HS. -other hsa-mir-106b Coronary Artery Disease 25415674 "a relationship between the miR-17-92 family and lipid metabolism, which merits further study." -other hsa-mir-17 Coronary Artery Disease 25415674 "a relationship between the miR-17-93 family and lipid metabolism, which merits further study." -other hsa-mir-18a Coronary Artery Disease 25415674 "a relationship between the miR-17-94 family and lipid metabolism, which merits further study." -other hsa-mir-92a Coronary Artery Disease 25415674 "a relationship between the miR-17-95 family and lipid metabolism, which merits further study." -other hsa-mir-449b Prostate Neoplasms 25416653 High miR-449b expression was shown to be an independent predictor of biochemical recurrence after radical prostatectomy. -other hsa-mir-200a Colorectal Carcinoma 25422078 "PZH can inhibit metastasis of colorectal cancer cells via modulating TGF-¦Â1/ZEB/miR-200 signaling network, which might be one of the mechanisms whereby PZH exerts its anticancer function." -other hsa-mir-200b Colorectal Carcinoma 25422078 "PZH can inhibit metastasis of colorectal cancer cells via modulating TGF-¦Â1/ZEB/miR-200 signaling network, which might be one of the mechanisms whereby PZH exerts its anticancer function." -other hsa-mir-200c Colorectal Carcinoma 25422078 "PZH can inhibit metastasis of colorectal cancer cells via modulating TGF-¦Â1/ZEB/miR-200 signaling network, which might be one of the mechanisms whereby PZH exerts its anticancer function." -other hsa-mir-449a "Carcinoma, Lung, Non-Small-Cell" 25424357 The tumor suppression role of microRNA-449a could be due to its promotion of tumor cell proliferation and its inhibition of tumor cell apoptosis. -other hsa-mir-141 "Carcinoma, Hepatocellular" 25425543 miR-141 functions as a tumor suppressor in HCC cells through the inhibition of HNF-3¦Â translation. -other hsa-mir-10b Neoplasms [unspecific] 25426550 "miR-520d-5p leads to reduced proliferation of tumor cells, and that high levels of miR-520d-5p correlate with higher survival rates of cancer patients." -other hsa-mir-520d Neoplasms [unspecific] 25426550 "miR-520d-5p leads to reduced proliferation of tumor cells, and that high levels of miR-520d-5p correlate with higher survival rates of cancer patients." -other hsa-mir-155 "Leukemia, Myeloid, Acute" 25428263 this 3-microRNA scoring system is simple and powerful for risk stratification of de novo AML patients. -other hsa-mir-203 "Leukemia, Myeloid, Acute" 25428263 this 3-microRNA scoring system is simple and powerful for risk stratification of de novo AML patients. -other hsa-mir-9 "Leukemia, Myeloid, Acute" 25428263 this 3-microRNA scoring system is simple and powerful for risk stratification of de novo AML patients. -other hsa-mir-23a Neoplasms [unspecific] 25429623 HSP70 could be beneficial to tumor cells by helping to maintain the expression of oncogenic miRNAs under conditions of cellular stress. -other hsa-mir-210 Tibial Meniscus Injuries 25430980 An intra-articular injection of ds miR-210 was effective in the healing of the damaged white zone meniscus through promotion of the collagen type 2 production from meniscus cells and through upregulated of VEGF and FGF2 from synovial cells. -other hsa-mir-193b Psoriasis 25431026 "the altered local miRNA changes seen in the RD are reflected in the circulating immune cells, suggesting that miRNAs may contribute to the pathogenesis of psoriasis." -other hsa-mir-223 Psoriasis 25431026 "the altered local miRNA changes seen in the RD are reflected in the circulating immune cells, suggesting that miRNAs may contribute to the pathogenesis of psoriasis." -other hsa-mir-26a Breast Neoplasms 25434799 miR-26a functions as a tumour suppressor in TNBC development and serves as a prognostic marker for breast cancer. -other hsa-mir-1181 Pancreatic Neoplasms 25444909 miR-1181 plays a vital role in inhibiting the CSCs-like phenotypes in pancreatic cancer and might represent a potential target for anti-pancreatic cancer. -other hsa-mir-23a Breast Neoplasms 25445205 "The overall concordance rates between miR-23a with HRG and FOXM1 tissue RNAs were 91% and 79%, respectively. The median follow-up period was 49 months. mi-23a and HRG RNA were significant independent prognostic markers in relapse-free survival. miR-23a may have an oncogenic function and enhance BC progression by directly activating FOXM1 and HRG at RNA level." -other hsa-mir-21 Neoplasms [unspecific] 25445583 "Further, during the transformation of HBE cells, inhibition of miR-21 with an miR-21 inhibitor increased levels of PDCD4, an inhibitor of neoplastic transformation;" -other hsa-mir-134 "Carcinoma, Embryonal" 25447206 FOXM1 is essential for human pluripotent stem cells and miR-134 attenuates its expression during differentiation. -other hsa-mir-21 "Carcinoma, Hepatocellular" 25447674 "I3C could function as a miR-21 regulator, leading to repression of the PTEN/AKT pathway and opening a new avenue for eradication of drug-resistant cells, thus potentially helping to improve the therapeutic outcome in patients diagnosed with HCC." -other hsa-mir-221 "Carcinoma, Hepatocellular" 25447674 "I3C could function as a miR-19 regulator, leading to repression of the PTEN/AKT pathway and opening a new avenue for eradication of drug-resistant cells, thus potentially helping to improve the therapeutic outcome in patients diagnosed with HCC." -other hsa-mir-222 "Carcinoma, Hepatocellular" 25447674 "I3C could function as a miR-20 regulator, leading to repression of the PTEN/AKT pathway and opening a new avenue for eradication of drug-resistant cells, thus potentially helping to improve the therapeutic outcome in patients diagnosed with HCC." -other hsa-mir-221 Breast Neoplasms 25447917 miR-221-3p may give crucial information about molecular mechanism of the disease upon PAK1 activity or different mechanisms with respect to histopathology and severity of breast cancer. -other hsa-mir-197 Lung Neoplasms 25451482 ER stress plays a major role in STAT6-induced apoptosis. -other hsa-mir-320a Colorectal Carcinoma 25458952 "microRNA-320b may function in competing with microRNA-320a. Thus, our study has proposed one novel mechanism for controlling colorectal cancer proliferation and invasion through homologous competition between microRNAs. This mechanism may be important for colorectal cancer metastasis." -other hsa-mir-320b Colorectal Carcinoma 25458952 "microRNA-320b may function in competing with microRNA-320a. Thus, our study has proposed one novel mechanism for controlling colorectal cancer proliferation and invasion through homologous competition between microRNAs. This mechanism may be important for colorectal cancer metastasis." -other hsa-mir-126 Prostate Neoplasms 25462564 The regulation of these factors by miR-126 and miR-149 is essential for syndecan-1-mediated development of androgen-refractory prostate cancer. -other hsa-mir-149 Prostate Neoplasms 25462564 The regulation of these factors by miR-126 and miR-149 is essential for syndecan-1-mediated development of androgen-refractory prostate cancer. -other hsa-mir-223 Atherosclerosis 25463083 "MiR-223-mediated suppression of TF expression provides a novel molecular mechanism for the regulation of coagulation cascade, and suggests a clue against thrombogenesis during the process of atherosclerotic plaque rupture." -other hsa-mir-29a Heart Failure 25464262 "MicroRNA-29a (miR-29a), a key regulator of tissue fibrosis, was highly expressed in the exosomes and the marginal area of the RIC group." -other hsa-mir-145 Acute Myocardial Infarction 25465803 Circulating miR-145 may be a novel biomarker for predicting long-term outcome after acute myocardial infarction. -other hsa-mir-144 Breast Neoplasms 25465851 "4 miRNAs that are generally dysregulated in human pathologies. Although these markers are not specific to certain diseases they may add to the diagnosis in combination with other markers, building a specific signature. Besides these dysregulated miRNAs, we propose a set of constant miRNAs that may be used as control markers." -other hsa-mir-146a Enterovirus Infection 25469565 EV71-induced cell apoptosis is partly governed by altered miRNAs. -other hsa-mir-370 Enterovirus Infection 25469565 EV71-induced cell apoptosis is partly governed by altered miRNAs. -other hsa-mir-122 "Fatty Liver, Non-Alcoholic" 25470250 "Finally, the liver appears to be an important source of circulating EVs in NAFLD animals as evidenced by the enrichment in blood with miR-122 and 192--two microRNAs previously described in chronic liver diseases, coupled with a corresponding decrease in expression of these microRNAs in the liver." -other hsa-mir-143 Colorectal Carcinoma 25474488 a role of the miR-143/145 cluster as a tumor suppressor in colorectal cancer through the inhibition of IGF1R translation. -other hsa-mir-145 Colorectal Carcinoma 25474488 a role of the miR-143/145 cluster as a tumor suppressor in colorectal cancer through the inhibition of IGF1R translation. -other hsa-mir-196b Leukemia 25475721 "miRNA-196b may play an essential role in the development of MLL-associated leukemias through inhibiting cell differentiation and apoptosis, while promoting cell proliferation." -other hsa-mir-153 Lung Neoplasms 25475731 significance of miR-153 and ADAM19 in the development and progression of NSCLC. -other hsa-mir-145 Neoplasms [unspecific] 25476854 large-scale prospective studies and additional improvements are urgently needed to confirm our findings and its utilization for routine clinical diagnosis in future. -other hsa-mir-143 Neoplasms [unspecific] 25477374 differences in these tumor suppressors might contribute to regional differences in normal colonic gene expression and modulate site-specific differences in malignant predisposition. -other hsa-mir-145 Neoplasms [unspecific] 25477374 differences in these tumor suppressors might contribute to regional differences in normal colonic gene expression and modulate site-specific differences in malignant predisposition. -other hsa-mir-200a "Carcinoma, Hepatocellular" 25482402 miR-200a may be recognized as a novel potential biomarker to predict the survival of patients with HCCs following liver transplantation. -other hsa-mir-155 Breast Neoplasms 25484137 a role of miR-155 in thiamine homeostasis and suggests a function of this oncogenic miRNA on breast cancer metabolism. -other hsa-mir-21 Peripheral Nerve Injury 25484256 miR-21 and miR-222 inhibited neuronal apoptosis at least partially through suppressing TIMP3 after peripheral nerve injury. -other hsa-mir-222 Peripheral Nerve Injury 25484256 miR-21 and miR-222 inhibited neuronal apoptosis at least partially through suppressing TIMP3 after peripheral nerve injury. -other hsa-mir-146a Neurodegenerative Diseases [unspecific] 25484882 "We particularly focus on the role played by miR-146a in the regulation and signaling mediated by one of the main pattern recognition receptors, toll/IL-1 receptors (TLRs)." -other hsa-mir-143 Neoplasms [unspecific] 25486198 "identify new molecules and mechanisms involved in the DDR, and to examine their role in tumor suppression and the clinical outcome of cancer patients." -other hsa-mir-16 Neoplasms [unspecific] 25486198 "identify new molecules and mechanisms involved in the DDR, and to examine their role in tumor suppression and the clinical outcome of cancer patients." -other hsa-mir-34 Neoplasms [unspecific] 25486198 "identify new molecules and mechanisms involved in the DDR, and to examine their role in tumor suppression and the clinical outcome of cancer patients." -other hsa-mir-203 Choriocarcinoma 25486432 "Besides EZH2, increases in miR-203 expression in the crypts at days 6 and 12 post infection correlated with reduced levels of its target WIF1; overexpression of miR-203 in primary colonocytes decreased WIF1 mRNA and protein levels." -other hsa-mir-142 Multiple Sclerosis 25486582 "AHSCT normalizes microRNA and gene expression, thereby improving the immunoregulatory network. These mechanisms may be important for disease control in the early periods after AHSCT." -other hsa-mir-155 Multiple Sclerosis 25486582 "AHSCT normalizes microRNA and gene expression, thereby improving the immunoregulatory network. These mechanisms may be important for disease control in the early periods after AHSCT." -other hsa-mir-16 Multiple Sclerosis 25486582 "AHSCT normalizes microRNA and gene expression, thereby improving the immunoregulatory network. These mechanisms may be important for disease control in the early periods after AHSCT." -other hsa-mir-155 Neoplasms [unspecific] 25486872 miR-155 expression is associated with chemoimmunotherapy outcome and is modulated by Bruton's tyrosine kinase inhibition with Ibrutinib. -other hsa-mir-148a Chronic Inflammation 25486906 "Twist1 and T-bet not only control the differentiation and function of Th1 cells, but also their persistence in chronic inflammation." -other hsa-mir-29a Human Immunodeficiency Virus Infection 25486977 links miR-29a to viral latency and suggests another approach to activate and destroy latent HIV-1 reservoirs. -other hsa-mir-34a Osteosarcoma 25490093 cell response to etoposide-induced DNA damage was not compromised in cells with dominant-negative p53 expression. -other hsa-mir-221 Melanoma 25492219 The hair shaft miR-221 levels were significantly higher in patients with MM than controls. -other hsa-mir-21 Rectal Neoplasms 25496125 "miR-21-5p as a promising predictive biomarker, which should aid in the selection of patients with cCR to nCRT that potentially could be spared from radical surgery." -other hsa-mir-21 Pleural Mesothelioma 25497279 a novel 6-microRNA signature (miR-Score) that can accurately predict prognosis of MPM patients. -other hsa-mir-221 Pleural Mesothelioma 25497279 a novel 6-microRNA signature (miR-Score) that can accurately predict prognosis of MPM patients. -other hsa-mir-222 Pleural Mesothelioma 25497279 a novel 6-microRNA signature (miR-Score) that can accurately predict prognosis of MPM patients. -other hsa-mir-23a Pleural Mesothelioma 25497279 a novel 6-microRNA signature (miR-Score) that can accurately predict prognosis of MPM patients. -other hsa-mir-30e Pleural Mesothelioma 25497279 a novel 6-microRNA signature (miR-Score) that can accurately predict prognosis of MPM patients. -other hsa-mir-31 Pleural Mesothelioma 25497279 a novel 6-microRNA signature (miR-Score) that can accurately predict prognosis of MPM patients. -other hsa-mir-137 Lung Neoplasms 25498886 miR-137 may be an independent favorable prognostic factor in NSCLC patients. -other hsa-mir-494 Oral Neoplasms 25500095 the role of miR-494 as a tumor suppressor miRNA in oral cancer. -other hsa-mir-2909 Immune System Disease [unspecific] 25500259 a mechanistic-pathway is proposed that links the epigenomic-interplay between MALT1 and miR-2909. -other hsa-mir-206 Pancreatic Adenocarcinoma 25500542 "miR-206 as a pleiotropic modulator of different hallmarks of cancer, and as such raising the intriguing possibility that miR-206 may be an attractive candidate for miRNA-based anticancer therapies." -other hsa-mir-23a "Squamous Cell Carcinoma, Tongue" 25501015 the molecular mechanisms underlying TSCC chemoresistance. -other hsa-mir-210 Osteoporosis 25503465 miR-210 played an important role in ameliorating the estrogen deficiency caused-postmenopausal osteoporosis through promotion the VEGF expression and osteoblast differentiation. -other hsa-mir-130 Pulmonary Hypertension 25505270 olecular cross-talk among the diverse cellular populations involved in PH. -other hsa-mir-301 Pulmonary Hypertension 25505270 olecular cross-talk among the diverse cellular populations involved in PH. -other hsa-mir-21 Glioma 25510379 An independent meta-analysis of five included studies was conducted to evaluate the diagnostic efficacy of miR-21 in patients with glioma -other hsa-mir-27a Obesity 25510894 "Correspondingly, the expression of miR-27a and miR-27b were up-regulated by persimmon tannin from Day 2 to Day 8 significantly." -other hsa-mir-27b Obesity 25510894 "Correspondingly, the expression of miR-27a and miR-27b were up-regulated by persimmon tannin from Day 2 to Day 8 significantly." -other hsa-mir-7 Breast Neoplasms 25511742 miR-7-5p has a critical function through blocking REG¦Ã in breast cancer cells. -other hsa-mir-25 "Carcinoma, Neuroendocrine" 25512615 "The pathogenesis of prostatic SCNC involves a p53 and Aurora Kinase A signaling mechanism, both potentially targetable pathways." -other hsa-mir-17 Retinoblastoma 25513843 "the antiproliferative property of pri-apt in RB cell lines, which can be readily modified by developing appropriate vectors for the delivery of the aptamer specifically to cancer cells." -other hsa-mir-18a Retinoblastoma 25513843 "the antiproliferative property of pri-apt in RB cell lines, which can be readily modified by developing appropriate vectors for the delivery of the aptamer specifically to cancer cells." -other hsa-mir-19b Retinoblastoma 25513843 "the antiproliferative property of pri-apt in RB cell lines, which can be readily modified by developing appropriate vectors for the delivery of the aptamer specifically to cancer cells." -other hsa-mir-92a Colorectal Carcinoma 25515201 miR-92a is involved in lymph node metastasis of CRC patients through PTEN-regulated PI3K/AKT signaling pathway. -other hsa-mir-122 Obesity 25515554 Elevated circulating miR-122 is positively associated with obesity and insulin resistance in young adults. These findings provide a better understanding regarding the role of miRNAs in adiposity and insulin sensitivity. -other hsa-mir-210 Endometriosis 25516558 "This work was supported in part by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (no. 13237327 to K.N., no. 25861500 to Y.K. and no. 23592407 to H.N.). There are no conflicts of interest to declare." -other hsa-mir-193b Laryngeal Neoplasms 25517434 Culturing the IL-10(+) Mos with effector CD8(+) T cells resulted in the suppression of CD8(+) T-cell activitie -other hsa-mir-99 Heart Failure 25517466 concept for identifying and activating conserved molecular programs to regenerate the damaged heart. -other hsa-mir-133a "Squamous Cell Carcinoma, Lung" 25518741 Further analysis of novel cancer signaling pathways modulated by the tumor-suppressive cluster miR-1/133a will provide insights into the molecular mechanisms of lung-SCC oncogenesis and metastasis -other hsa-mir-100 Coronary Atherosclerosis 25519160 miR-100 might be released into the coronary circulation from vulnerable coronary plaques. This study provides insights into the role of miRNAs in coronary atherosclerotic disease. -other hsa-mir-1226 Lung Neoplasms 25519225 the screening approach used in this study can identify clinically relevant synthetic lethal interactions and that vitamin D receptor agonists may show enhanced efficacy in p53-negative lung cancer patients. -other hsa-mir-92a Lung Neoplasms 25519225 the screening approach used in this study can identify clinically relevant synthetic lethal interactions and that vitamin D receptor agonists may show enhanced efficacy in p53-negative lung cancer patients. -other hsa-mir-155 "Adenocarcinoma, Pancreatic Ductal" 25520858 "MiR-21, miR-155 and miR-216 in stool have the potential of becoming biomarkers for screening PDAC." -other hsa-mir-126 "Squamous Cell Carcinoma, Lung" 25521201 rule discovery followed by distance separation is a powerful computational method to identify reliable miRNA biomarkers. The visualization of the rules and the clear separation between the normal and cancer samples by our rules will help biology experts for their analysis and biological interpretation. -other hsa-mir-205 "Squamous Cell Carcinoma, Lung" 25521201 rule discovery followed by distance separation is a powerful computational method to identify reliable miRNA biomarkers. The visualization of the rules and the clear separation between the normal and cancer samples by our rules will help biology experts for their analysis and biological interpretation. -other hsa-mir-98 "Squamous Cell Carcinoma, Lung" 25521201 rule discovery followed by distance separation is a powerful computational method to identify reliable miRNA biomarkers. The visualization of the rules and the clear separation between the normal and cancer samples by our rules will help biology experts for their analysis and biological interpretation. -other hsa-mir-375 Tongue Neoplasms 25521291 the four anti-cancer drugs examined in this study induce the expression of tumor suppressor miR-375 in tongue cancer. -other hsa-mir-155 Breast Neoplasms 25523096 "the miRNA and isomiR levels in BC, which indicates biological roles of isomiRs." -other hsa-mir-21 Breast Neoplasms 25523096 "the miRNA and isomiR levels in BC, which indicates biological roles of isomiRs." -other hsa-mir-221 Breast Neoplasms 25523096 "the miRNA and isomiR levels in BC, which indicates biological roles of isomiRs." -other hsa-mir-25 Breast Neoplasms 25523096 "the miRNA and isomiR levels in BC, which indicates biological roles of isomiRs." -other hsa-mir-30e Breast Neoplasms 25523096 "the miRNA and isomiR levels in BC, which indicates biological roles of isomiRs." -other hsa-mir-143 Myeloproliferative Neoplasms 25527813 Our findings of aberrant miR-143 expression support the concept that factors other than JAK2 V617F mutation may contribute to the pathogenesis and some clinical signs of MPNs. -other hsa-mir-134 "Carcinoma, Endometrial" 25528443 endogenous miR-134 regulation in HuECSCs may suppress tumourigenesis in human endometrial carcinoma. -other hsa-mir-22 Vascular Disease [unspecific] 25530680 Mox-LDL interferes with parameters associated with angiogenesis. They suggest that high LDL levels in patients would impair their endothelial cell capacity to cope with a damaged endothelium contributing negatively to the progression of the atheroma plaque. -other hsa-mir-486 "Leukemia, Myeloid" 25533034 "miR-486-5p cooperates with GATA1s in supporting the growth and survival, and the aberrant erythroid phenotype of the megakaryocytic leukemias of DS." -other hsa-mir-21 Ischemia-Reperfusion Injury 25536091 isoflurane mediates protection of cardiomyocytes against oxidative stress via an miR-21/programmed cell death protein 4 pathway. -other hsa-mir-146a Ovarian Neoplasms 25537514 a proportion of patients with wild-type BRCA1/2 ovarian cancers benefit from platinum-based chemotherapy and that the patients who benefit could be predicted from BRCA1/2-directed miRNA signature. -other hsa-mir-148a Ovarian Neoplasms 25537514 a proportion of patients with wild-type BRCA1/2 ovarian cancers benefit from platinum-based chemotherapy and that the patients who benefit could be predicted from BRCA1/2-directed miRNA signature. -other hsa-mir-545 Ovarian Neoplasms 25537514 a proportion of patients with wild-type BRCA1/2 ovarian cancers benefit from platinum-based chemotherapy and that the patients who benefit could be predicted from BRCA1/2-directed miRNA signature. -other hsa-mir-92b Gastric Neoplasms 25537895 "miR-92b promotes the migration, adhesion and invasion of human gastric cancer cell line SGC7901 by mediating epithelial-mesenchymal transition, and may accelerate tumor cell metastasis via signaling pathways other than PI3K/Akt pathway." -other hsa-let-7a Cervical Neoplasms 25539644 "existence of a functional loop involving Let-7a, STAT3 and miR-21 which were found potentially regulated by viral oncoprotein E6." -other hsa-mir-21 Cervical Neoplasms 25539644 "existence of a functional loop involving Let-7a, STAT3 and miR-21 which were found potentially regulated by viral oncoprotein E6." -other hsa-mir-125b Breast Neoplasms 25539763 "context-dependent roles are not clear in breast cancer, a diverse expression pattern of ALCAM mRNA was detected in a panel of breast cancer patient samples. Differentially expressed/regulated cancer-related genes upon miR-125b expression along with the significant increase of ALCAM are of future interest to understand how deregulated expression of miR-125b may have a tumor suppressor role in breast and other cancers." -other hsa-mir-15a Neoplasms [unspecific] 25540364 viral RNAs can exert their functions as competing endogenous RNAs (ceRNAs) toward microRNA and participate in important cellular processes. -other hsa-mir-155 "Lymphoma, B-Cell" 25541152 "Importantly, the targeting of miRNAs (like use of anti-miR-155 or miR-34a mimic) could provide a novel therapeutic approach as evidenced by tumour regression in xenograft mouse models and initial promising data from clinical trials." -other hsa-mir-34a "Lymphoma, B-Cell" 25541152 "Importantly, the targeting of miRNAs (like use of anti-miR-155 or miR-34a mimic) could provide a novel therapeutic approach as evidenced by tumour regression in xenograft mouse models and initial promising data from clinical trials." -other hsa-mir-125a Glioblastoma 25542152 "TAZ deregulation in glioma cells, and also demonstrated a tumor suppressor role of miR-125a-5p in glioblastoma cells." -other hsa-mir-31 Colorectal Carcinoma 25543122 Overexpression of miR-31 and -182 in CRC leads to more aggressive cancer. -other hsa-mir-21 "Leukemia, Myeloid, Acute" 25543261 deregulated miR-21 expression may contribute to disease pathogenesis in NPM1-mutated AMLs -other hsa-mir-33a Lung Neoplasms 25544258 the treatment of lung cancer and clarify the mechanism of its progression. -other hsa-mir-133a Muscle Diseases [unspecific] 25547110 human skeletal muscle differentiation and development in healthy and disease states. -other hsa-mir-133b Muscle Diseases [unspecific] 25547110 human skeletal muscle differentiation and development in healthy and disease states. -other hsa-mir-206 Muscle Diseases [unspecific] 25547110 human skeletal muscle differentiation and development in healthy and disease states. -other hsa-mir-20a Muscle Diseases [unspecific] 25547110 human skeletal muscle differentiation and development in healthy and disease states. -other hsa-mir-26 Muscle Diseases [unspecific] 25547110 human skeletal muscle differentiation and development in healthy and disease states. -other hsa-mir-30 Muscle Diseases [unspecific] 25547110 human skeletal muscle differentiation and development in healthy and disease states. -other hsa-mir-155 Neoplasms [unspecific] 25548153 "overexpression of miR-155 in tumor-specific T cells can be used to increase the effectiveness of adoptive immunotherapies in a cell-intrinsic manner without the need for life-threatening, lymphodepleting maneuvers." -other hsa-mir-150 "Carcinoma, Hepatocellular" 25549355 re-expression of MMP14 in hepatoma cells partially reverses the effect of miR-150-5p in inhibiting cell invasion -other hsa-mir-21 Neoplasms [unspecific] 25550434 ESCRT-I complex in the regulation of productive free uptake of anti-miRs and reveal potential avenues for improving oligonucleotide free uptake by cancer cells. -other hsa-mir-193b Breast Neoplasms 25550792 "miR-193b as a novel tumor suppressor plays an important role in breast cancer progression, understanding the mechanisms could account for the aggressive behaviour of breast cancer." -other hsa-mir-451 Bladder Neoplasms 25550801 "miR451 should be a tumor-suppressing gene in bladder cancer. miR-451 could maintain the bladder tumor cells in epithelial phenotype, inhibit EMT process, thereby reducing the invasion and migration of tumor cells." -other hsa-mir-139 "Carcinoma, Colon" 25550849 miR-139-3p has potential as a prognostic biomarker for colon cancer. Further prospective studies are required to validate this result. -other hsa-mir-145 "Adenocarcinoma, Esophageal" 25551563 "While expression of miR-145 in ESCC stopped proliferation and invasion, expression of miR-145 in EAC cells enhanced invasion and anoikis resistance. Although more work is required to understand how miR-145 conveys these effects, expression of miR-145 appears to promote EAC progression by enhancing invasion and protection against anoikis, which could in turn facilitate distant metastasis." -other hsa-mir-9 "Carcinoma, Hepatocellular" 25552204 the potential of miR-9 as a novel prognostic biomarker for HCC. Large well-designed studies with diverse populations and functional evaluations are warranted to confirm and extend our findings. -other hsa-mir-183 Prostate Neoplasms 25556023 the regulation of prostate-specific antigen and may eventually affect clinical decision making in prostate cancer. -other hsa-mir-574 Breast Neoplasms 25560734 functional screening mediated by miRNA libraries can provide new insights into the genes essential for tamoxifen response in breast cancer. -other hsa-mir-146a Liver Diseases [unspecific] 25562147 a critical role for miRNAs in the pathogenesis of NAFLD. -other hsa-mir-146b Liver Diseases [unspecific] 25562147 a critical role for miRNAs in the pathogenesis of NAFLD. -other hsa-mir-152 Liver Diseases [unspecific] 25562147 a critical role for miRNAs in the pathogenesis of NAFLD. -other hsa-mir-200a Liver Diseases [unspecific] 25562147 a critical role for miRNAs in the pathogenesis of NAFLD. -other hsa-mir-200b Liver Diseases [unspecific] 25562147 a critical role for miRNAs in the pathogenesis of NAFLD. -other hsa-mir-200c Liver Diseases [unspecific] 25562147 a critical role for miRNAs in the pathogenesis of NAFLD. -other hsa-mir-222 Breast Neoplasms 25562151 "¦Â-elemene could influence MDR related miRNA expression and subsequently regulate the expression of the target genes PTEN and Pgp, which may lead to reduction of the viability of the chemo-resistant breast cancer cells." -other hsa-mir-29a Breast Neoplasms 25562151 "¦Â-elemene could influence MDR related miRNA expression and subsequently regulate the expression of the target genes PTEN and Pgp, which may lead to reduction of the viability of the chemo-resistant breast cancer cells." -other hsa-mir-34a Breast Neoplasms 25562151 "¦Â-elemene could influence MDR related miRNA expression and subsequently regulate the expression of the target genes PTEN and Pgp, which may lead to reduction of the viability of the chemo-resistant breast cancer cells." -other hsa-mir-452 Breast Neoplasms 25562151 "¦Â-elemene could influence MDR related miRNA expression and subsequently regulate the expression of the target genes PTEN and Pgp, which may lead to reduction of the viability of the chemo-resistant breast cancer cells." -other hsa-mir-223 Liver Failure 25562161 "miR-223 acted to inhibit IL-1¦Â production via AIM2 pathway, suppressing Kupffer cells pro-inflammatory activation at the early stage of ALF. Thus, it played an important role in the pathogenesis of ALF." -other hsa-mir-212 Osteosarcoma 25562164 The miR-212/Sox4 interaction plays an important role of in the osteosarcoma progression. -other hsa-mir-145 Glioblastoma 25564360 Synthetic miR-145 Mimic Enhances the Cytotoxic Effect of the Antiangiogenic Drug Sunitinib in Glioblastoma. -other hsa-mir-215 Renal Fibrosis 25565137 MicroRNA-215 Regulates Fibroblast Function: Insights from a Human Fibrotic Disease. -other hsa-mir-192 Bladder Neoplasms 25566965 miR-192 may be a suppressor for bladder cancer cells by cell cycle regulation. -other hsa-mir-28 "Leukemia, T-Cell" 25568327 miR-28 may play an important role in HTLV-1 transmission. -other hsa-mir-218 "Carcinoma, Gallbladder" 25569100 "CCAT1 is a driver of malignancy, which acts in part through 'spongeing' miRNA-218-5p." -other hsa-mir-34a Bladder Neoplasms 25572695 polyphenols in PRE can be potential molecular clusters to suppress bladder cancer cell EJ proliferation via p53/miR-34a axis. -other hsa-mir-125b Lung Neoplasms 25573191 miR-125b may function as an oncogene in lung cancer. -other hsa-mir-214 Coronary Artery Disease 25575606 increased miR-214 level may be used to predict the presence and severity of coronary lesions in CAD patients. -other hsa-mir-129 Oral Leukoplakia 25576219 "a miRNA-mRNA regulatory network associated with the malignant transformation of OLK, and screened out some miRNAs and transcription factors that may have prominent roles during OLK malignant progression." -other hsa-mir-31 Oral Leukoplakia 25576219 "a miRNA-mRNA regulatory network associated with the malignant transformation of OLK, and screened out some miRNAs and transcription factors that may have prominent roles during OLK malignant progression." -other hsa-mir-339 Oral Leukoplakia 25576219 "a miRNA-mRNA regulatory network associated with the malignant transformation of OLK, and screened out some miRNAs and transcription factors that may have prominent roles during OLK malignant progression." -other hsa-mir-93 "Squamous Cell Carcinoma, Head and Neck" 25578493 miR-93 may be a valuable marker for the prediction of metastasis and prognosis in HNSCC. -other hsa-mir-152 Neoplasms [unspecific] 25578780 XIST in GSCs and important clues for understanding the key roles of lncRNA-miRNA functionalnetwork in human glioma. -other hsa-mir-210 "Leukemia, Myeloid" 25579461 The suitability of the method for biological samples was tested by detecting microRNA-210 from transfected K562 cells. -other hsa-mir-34a Neoplasms [unspecific] 25579512 Regulatory mechanisms and clinical perspectives of miR-34a in cancer. -other hsa-mir-21 Glioblastoma 25582055 ADAR2 is a key factor for maintaining edited-miRNA population and balancing the expression of several essential miRNAs involved in cancer. -other hsa-mir-221 Glioblastoma 25582055 ADAR2 is a key factor for maintaining edited-miRNA population and balancing the expression of several essential miRNAs involved in cancer. -other hsa-mir-222 Glioblastoma 25582055 ADAR2 is a key factor for maintaining edited-miRNA population and balancing the expression of several essential miRNAs involved in cancer. -other hsa-mir-16 "Cardiomyopathy, Hypertrophic" 25583328 "Attenuation of microRNA-16 derepresses the cyclins D1, D2 and E1 to provoke cardiomyocyte hypertrophy." -other hsa-mir-221 Bladder Neoplasms 25585941 "The expression of MMP-2, MMP-9 and VEGF-C were reduced, resulting in reduced invasiveness and infiltration capability of bladder cancer cells, thereby inhibiting the immune evasion of bladder cancer cells." -other hsa-mir-200a Neoplasms [unspecific] 25586904 exposure to arsenic rapidly induces a multifaceted dedifferentiation program and miR-205 has potential to be used as a marker of\ arsenic exposure as well as a maker of early urothelial carcinoma detection. -other hsa-mir-200b Neoplasms [unspecific] 25586904 exposure to arsenic rapidly induces a multifaceted dedifferentiation program and miR-205 has potential to be used as a marker of\ arsenic exposure as well as a maker of early urothelial carcinoma detection. -other hsa-mir-200c Neoplasms [unspecific] 25586904 exposure to arsenic rapidly induces a multifaceted dedifferentiation program and miR-205 has potential to be used as a marker of\ arsenic exposure as well as a maker of early urothelial carcinoma detection. -other hsa-mir-205 Neoplasms [unspecific] 25586904 exposure to arsenic rapidly induces a multifaceted dedifferentiation program and miR-205 has potential to be used as a marker of\ arsenic exposure as well as a maker of early urothelial carcinoma detection. -other hsa-mir-29b-2 Diabetes Mellitus 25587719 The pathogenic role of persistent milk signaling in mTORC1- and milk-microRNA-driven type 2 diabetes mellitus. -other hsa-mir-1 Myocardial Infarction 25588055 Downregulation of IGF1 specific miRNA-1 and -133 but not miR-145 expression was also confirmed. -other hsa-mir-15 Breast Neoplasms 25594541 the expression of the miR-15 family contributes to increased radiosensitivity of breast cancer cells by influencing G2/M checkpoint proteins. -other hsa-mir-500 Gastric Neoplasms 25595906 "we report the uncovering of a novel mechanism for constitutive NF-¦ÊB activation, indicating the potentially pivotal role of miR-500 in the progression of gastric cancer." -other hsa-mir-34a "Carcinoma, Hepatocellular" 25596083 the expression of miR-34a in HCC biopsy specimens has an independent predictive value of early recurrence after RFA. -other hsa-mir-22 Liver Neoplasms 25596928 "bile acid-activated FXR stimulates miR-22-silenced CCNA2, a novel pathway for FXR to exert its protective effect in the gastrointestinal tract." -other hsa-mir-125b Prostate Neoplasms 25597828 "use of a combination of different types of genetic markers in ejaculate together with serum PSA are at least as sensitive as those reported in DRE urine. Furthermore, a combination of serum PSA and selected miRNAs improved prediction of prostate cancer status. This approach may be helpful in triaging patients for MRI and biopsy, when confirmed by larger studies." -other hsa-mir-200b Prostate Neoplasms 25597828 "use of a combination of different types of genetic markers in ejaculate together with serum PSA are at least as sensitive as those reported in DRE urine. Furthermore, a combination of serum PSA and selected miRNAs improved prediction of prostate cancer status. This approach may be helpful in triaging patients for MRI and biopsy, when confirmed by larger studies." -other hsa-mir-200c Prostate Neoplasms 25597828 "use of a combination of different types of genetic markers in ejaculate together with serum PSA are at least as sensitive as those reported in DRE urine. Furthermore, a combination of serum PSA and selected miRNAs improved prediction of prostate cancer status. This approach may be helpful in triaging patients for MRI and biopsy, when confirmed by larger studies." -other hsa-mir-375 Prostate Neoplasms 25597828 "use of a combination of different types of genetic markers in ejaculate together with serum PSA are at least as sensitive as those reported in DRE urine. Furthermore, a combination of serum PSA and selected miRNAs improved prediction of prostate cancer status. This approach may be helpful in triaging patients for MRI and biopsy, when confirmed by larger studies." -other hsa-mir-205 "Carcinoma, Renal Cell" 25600645 how overexpression of MALAT1 confers an oncogenic function in RCC that may offer a novel theranostic marker in this disease. -other hsa-mir-10b Colorectal Carcinoma 25606801 miR-10b is potentially involved in the invasion of colorectal cancer. -other hsa-mir-100 Pancreatic Neoplasms 25607660 This pilot study highlights miRNAs that may aid in preoperative risk stratification of IPMNs and provides novel insights into miRNA-mediated progression to pancreatic malignancy. The miRNAs identified here and in other recent investigations warrant evaluation in biofluids in a well-powered prospective cohort of individuals newly-diagnosed with IPMNs and other pancreatic cysts and those at increased genetic risk for these lesions. -other hsa-mir-126 Pancreatic Neoplasms 25607660 This pilot study highlights miRNAs that may aid in preoperative risk stratification of IPMNs and provides novel insights into miRNA-mediated progression to pancreatic malignancy. The miRNAs identified here and in other recent investigations warrant evaluation in biofluids in a well-powered prospective cohort of individuals newly-diagnosed with IPMNs and other pancreatic cysts and those at increased genetic risk for these lesions. -other hsa-mir-130a Pancreatic Neoplasms 25607660 This pilot study highlights miRNAs that may aid in preoperative risk stratification of IPMNs and provides novel insights into miRNA-mediated progression to pancreatic malignancy. The miRNAs identified here and in other recent investigations warrant evaluation in biofluids in a well-powered prospective cohort of individuals newly-diagnosed with IPMNs and other pancreatic cysts and those at increased genetic risk for these lesions. -other hsa-mir-342 Pancreatic Neoplasms 25607660 This pilot study highlights miRNAs that may aid in preoperative risk stratification of IPMNs and provides novel insights into miRNA-mediated progression to pancreatic malignancy. The miRNAs identified here and in other recent investigations warrant evaluation in biofluids in a well-powered prospective cohort of individuals newly-diagnosed with IPMNs and other pancreatic cysts and those at increased genetic risk for these lesions. -other hsa-mir-99a Pancreatic Neoplasms 25607660 This pilot study highlights miRNAs that may aid in preoperative risk stratification of IPMNs and provides novel insights into miRNA-mediated progression to pancreatic malignancy. The miRNAs identified here and in other recent investigations warrant evaluation in biofluids in a well-powered prospective cohort of individuals newly-diagnosed with IPMNs and other pancreatic cysts and those at increased genetic risk for these lesions. -other hsa-mir-99b Pancreatic Neoplasms 25607660 This pilot study highlights miRNAs that may aid in preoperative risk stratification of IPMNs and provides novel insights into miRNA-mediated progression to pancreatic malignancy. The miRNAs identified here and in other recent investigations warrant evaluation in biofluids in a well-powered prospective cohort of individuals newly-diagnosed with IPMNs and other pancreatic cysts and those at increased genetic risk for these lesions. -other hsa-let-7b Colorectal Carcinoma 25611389 Genome-wide mRNA and miRNA expression profiling reveal multiple regulatory networks in colorectal cancer. -other hsa-mir-375 Breast Neoplasms 25613180 biochanin A promoted ER¦Á-positive cell proliferation through miR-375 activation and this mechanism is possibly involving in a miR-375 and ER¦Á feedback loop. -other hsa-mir-205 Malignant Neoplasms [unspecific] 25613953 "miRNA-205 is a promising biomarker for predicting the recurrence and progression of patients with adenocarcinomas or breast cancer. Owing to its complex roles, further relevant studies are warranted." -other hsa-mir-558 Neuroblastoma 25616966 "miR-558 induces the transcriptional activation of HPSE via the binding site within promoter, thus facilitating the tumorigenesis and aggressiveness of NB." -other hsa-mir-28 Neoplasms [unspecific] 25617309 miR-28-5p promotes chromosomal instability in VHL-associated cancers by inhibiting Mad2 translation. -other hsa-mir-146b Atrial Fibrillation 25617731 miR-146b-5p probably acts as an intracellular mediator in the maladaptive remodeling in atrial fibrosis in atrial fibrillation. -other hsa-mir-210 Gastric Neoplasms 25618442 MIR210 is often highly overexpressed in gastric cancer -other hsa-mir-10b Bladder Neoplasms 25620614 "urine miR-210, miR-10b, and miR-29c are promising tumor markers for BC: bilharzial and nonbilharzial." -other hsa-mir-210 Bladder Neoplasms 25620614 "urine miR-210, miR-10b, and miR-29c are promising tumor markers for BC: bilharzial and nonbilharzial." -other hsa-mir-221 Bladder Neoplasms 25620614 "urine miR-210, miR-10b, and miR-29c are promising tumor markers for BC: bilharzial and nonbilharzial." -other hsa-mir-23a Bladder Neoplasms 25620614 "urine miR-210, miR-10b, and miR-29c are promising tumor markers for BC: bilharzial and nonbilharzial." -other hsa-mir-29c Bladder Neoplasms 25620614 "urine miR-210, miR-10b, and miR-29c are promising tumor markers for BC: bilharzial and nonbilharzial." -other hsa-mir-122 Breast Neoplasms 25621950 "by modifying glucose utilization by recipient premetastatic niche cells, cancer-derived extracellular miR-122 is able to reprogram systemic energy metabolism to facilitate disease progression." -other hsa-mir-551b Gastric Neoplasms 25623763 Expression of miR-551b-3p in gastric cancer cell lines and tissues and its clinical significance. -other hsa-mir-21 Glioblastoma 25628933 Dox and miR-21 inhibitor therapy can sensitize GBM resistant cells to anthracyclines by enhancing apoptosis. -other hsa-mir-451a Glioma 25629604 Effective control of growing cells near BV sites in addition to relocalization of invisible migratory cells back to the resection site was suggested as a way of eradicating these migratory cells. -other hsa-mir-146a Rheumatoid Arthritis 25630616 "the miRNA-146 GG genotype might increase the risk of RA in females, and CC genotype may influence disease activity when evaluated with DAS28 score." -other hsa-mir-181b Glioblastoma 25633526 NF-¦ÊB activation by DNA damage in GBM cells confers resistance to radiation-induced death. -other hsa-mir-145 "Carcinoma, Endometrial" 25634023 "OCT4-pg5 can act as an RNA sponge to protect OCT4 transcripts from being inhibited by miR-145, providing novel insight into the control of OCT4 expression." -other hsa-mir-29 Gastric Neoplasms 25634213 a global mechanism for understanding the efficacious effects of cytotoxic chemotherapy in gastric cancer. -other hsa-let-7g Atypical Teratoid Tumor 25638158 LIN28A knockdown led to increased expression of let-7b and let-7g microRNAs and a down-regulation of KRAS mRNA. -other hsa-mir-210 Gallstones 25639987 An integrated analysis of differential miRNA and mRNA expressions in human gallstones. -other hsa-mir-1266 Breast Neoplasms 25640367 Association of miR-1266 with recurrence/metastasis potential in estrogen receptor positive breast cancer patients. -other hsa-mir-221 "Carcinoma, Lung, Non-Small-Cell" 25641933 Growth inhibitory effects of miR-221 and miR-222 in non-small cell lung cancer cells. -other hsa-mir-222 "Carcinoma, Lung, Non-Small-Cell" 25641933 Growth inhibitory effects of miR-221 and miR-222 in non-small cell lung cancer cells. -other hsa-mir-484 Breast Neoplasms 25643696 Cytidine Deaminase Axis Modulated by miR-484 Differentially Regulates Cell Proliferation and Chemoresistance in Breast Cancer. -other hsa-mir-206 Rhabdomyosarcoma 25644430 SMYD1 and G6PD modulation are critical events for miR-206-mediated differentiation of rhabdomyosarcoma. -other hsa-mir-21 Cardiomegaly 25644540 miR-21: a star player in cardiac hypertrophy. -other hsa-mir-200b Malignant Neoplasms [unspecific] 25644713 YY1 acts as novel critical interface between epigenetic code and miRNAs machinery under chronic hypoxia in malignancy. -other hsa-mir-200c Malignant Neoplasms [unspecific] 25644713 YY1 acts as novel critical interface between epigenetic code and miRNAs machinery under chronic hypoxia in malignancy. -other hsa-mir-3189 Glioblastoma 25645911 Anti-tumoral effects of miR-3189-3p in glioblastoma. -other hsa-mir-155 Lymphoma 25645925 miR-155 controls the outcome of the GC reaction by modulating its initiation (Aicda) and termination (Socs1/p53 response) -other hsa-mir-328 Lung Neoplasms 25646356 The predictive value and potential mechanisms of miRNA-328 and miRNA-378 for brain metastases in operable and advanced non-small-cell lung cancer. -other hsa-mir-378 Lung Neoplasms 25646356 The predictive value and potential mechanisms of miRNA-328 and miRNA-378 for brain metastases in operable and advanced non-small-cell lung cancer. -other hsa-mir-146a Gout 25646371 Role of miR-146a in regulation of the acute inflammatory response to monosodium urate crystals. -other hsa-mir-188 "Leukemia, Myeloid" 25646775 Identification of let-7a-2-3p or/and miR-188-5p as prognostic biomarkers in cytogenetically normal acute myeloid leukemia. -other hsa-mir-122 Hepatitis C Virus Infection 25646812 Circulating miRNA-122 levels are associated with hepatic necroinflammation and portal hypertension in HIV/HCV coinfection. -other hsa-mir-34b Breast Neoplasms 25647415 The regulation and function of miR-21-FOXO3a-miR-34b/c signaling in breast cancer. -other hsa-mir-34c Breast Neoplasms 25647415 The regulation and function of miR-21-FOXO3a-miR-34b/c signaling in breast cancer. -other hsa-mir-206 Gastric Neoplasms 25653235 Activation of PAX3-MET pathways due to miR-206 loss promotes gastric cancer metastasis. -other hsa-mir-30a "Carcinoma, Hepatocellular" 25654285 "Effect of miR-30a-5p on the proliferation, apoptosis, invasion and migration of SMCC-7721 human hepatocellular carcinoma cells" -other hsa-mir-143 Vascular Disease [unspecific] 25655189 Myocyte Enhancer Factor 2A Regulates Hydrogen Peroxide-Induced Senescence of Vascular Smooth Muscle Cells Via microRNA-143. -other hsa-mir-145 Vascular Disease [unspecific] 25655189 Myocyte Enhancer Factor 2A Regulates Hydrogen Peroxide-Induced Senescence of Vascular Smooth Muscle Cells Via microRNA-143. -other hsa-mir-143 Gastric Neoplasms 25656032 Expression of miR-143 and miR-145 and their functional study in gastric carcinoma. -other hsa-mir-145 Gastric Neoplasms 25656032 Expression of miR-143 and miR-145 and their functional study in gastric carcinoma. -other hsa-mir-21 Multiple Myeloma 25656574 PSMB4 promotes multiple myeloma cell growth by activating NF-¦ÊB-miR-21 signaling. -other hsa-mir-29a "Carcinoma, Breast" 25656908 Epigenetic Regulation of miR-29s Affects the Lactation Activity of Dairy Cow Mammary Epithelial Cells. -other hsa-mir-29b "Carcinoma, Breast" 25656908 Epigenetic Regulation of miR-29s Affects the Lactation Activity of Dairy Cow Mammary Epithelial Cells. -other hsa-mir-29c "Carcinoma, Breast" 25656908 Epigenetic Regulation of miR-29s Affects the Lactation Activity of Dairy Cow Mammary Epithelial Cells. -other hsa-mir-21 Coronary Artery Disease 25656948 "MiR-34a, miR-21 and miR-23a as potential biomarkers for coronary artery disease: a pilot microarray study and confirmation in a 32 patient cohort." -other hsa-mir-23a Coronary Artery Disease 25656948 "MiR-34a, miR-21 and miR-23a as potential biomarkers for coronary artery disease: a pilot microarray study" -other hsa-mir-34a Coronary Artery Disease 25656948 "MiR-34a, miR-21 and miR-23a as potential biomarkers for coronary artery disease: a pilot microarray study and confirmation in a 32 patient cohort." -other hsa-mir-101 Bladder Neoplasms 25658842 "miR-101 suppresses VEGF-C expression, inhibits cell migration and invasion, and increases cisplatin sensitivity in bladder cancer cells. " -other hsa-mir-509 Breast Neoplasms 25659578 suppresses brain metastasis of breast cancer cells by modulating RhoC and TNF-¦Á. -other hsa-mir-494 Preeclampsia 25660325 we report an unrecognized mechanism of miR-494 affecting dMSC proliferation and function in the pathology of PE. -other hsa-mir-760 Breast Neoplasms 25661353 Systematic analysis of gene expression pattern in has-miR-760 overexpressed resistance of the MCF-7 human breast cancer cell to doxorubicin. -other hsa-mir-592 Colorectal Carcinoma 25661360 Up-regulation of miR-592 correlates with tumor progression and poor prognosis in patients with colorectal cancer. -other hsa-mir-145 "Carcinoma, Lung, Non-Small-Cell" 25661374 Low miR-145 expression level is associated with poor pathological differentiation and poor prognosis in non-small cell lung cancer. -other hsa-mir-122 Hepatitis C Virus Infection 25662750 miR-122 stimulates hepatitis C virus RNA synthesis by altering the balance of viral RNAs engaged in replication versus translation. -other hsa-mir-494 Glioblastoma 25662849 "miR-494-3p Regulates Cellular Proliferation, Invasion, Migration, and Apoptosis by PTEN/AKT Signaling in Human Glioblastoma Cells." -other hsa-mir-375 Breast Neoplasms 25663261 This study demonstrated that formononetin promoted ER¦Á-positive cell proliferation through miR-375 activation and this mechanism is possibly involving in a miR-375 and ER¦Á feedback loop. -other hsa-mir-137 "Carcinoma, Gastric" 25663388 Epigenetic silencing of miR-137 is a frequent event in gastric carcinogenesis. -other hsa-mir-423 Breast Neoplasms 25663458 Genetic analysis and preliminary function study of miR-423 in breast cancer. -other hsa-mir-199a Cystic Fibrosis 25665524 Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation. -other hsa-mir-15b Vascular Disease [unspecific] 25665638 "We focus on the diverse roles of miR-15b in the occurrence, progression and prognosis of vascular diseases,with particular emphasis on preeclampsia, a hypertensive disorder related to endovascular dysfunction in the placenta." -other hsa-mir-31 Inflammatory Bowel Diseases 25665881 Differential expression of miR-31 between inflammatory bowel disease and microscopic colitis. -other hsa-mir-155 Osteosarcoma 25666090 miR-155 promotes the growth of osteosarcoma in a HBP1-dependent mechanism. -other hsa-mir-145 "Carcinoma, Cervical" 25666710 MicroRNA-145 contributes to enhancing radiosensitivity of cervical cancer cells. -other hsa-let-7a "Carcinoma, Breast" 25669981 Metabolic reprogramming of metastatic breast cancer and melanoma by let-7a microRNA. -other hsa-mir-95 Colorectal Carcinoma 25671802 Glargine Promotes Human Colorectal Cancer Cell Proliferation via Upregulation of miR-95. -other hsa-mir-155 Glioma 25672607 miR-155 contributes to the progression of glioma by enhancing Wnt/¦Â-catenin pathway. -other hsa-mir-200c "Carcinoma, Gastric" 25672630 DZNep raises miR-200c expression to delay the invasion and migration of MGC-803 gastric carcinoma cells -other hsa-mir-25 Neoplasms [unspecific] 25672882 miR-25 is suggested to be important in TNF-¦Á-induced abnormal proliferation of vascular smooth muscle cells (VSMCs). -other hsa-mir-199a Hepatoblastoma 25673149 The miR-199a/Brm/EGR1 axis is a determinant of anchorage-independent growth in epithelial tumor cell lines. -other hsa-mir-182 Urinary Bladder Cancer 25676538 This study shows that the level of miR-182 is higher in cytology specimens from high-grade UCC patients as compared to normal controls.Measuring miR-182 may provide a potential alternative or adjunct approach for screening high-grade UCC. -other hsa-mir-17 Glioblastoma 25677619 Our findings suggest that engineering of tumor antigen-specific CD8(+) T-cells to express miR-17-92 may improve the potency of cancer immunotherapy. -other hsa-mir-18 Glioblastoma 25677619 Our findings suggest that engineering of tumor antigen-specific CD8(+) T-cells to express miR-17-92 may improve the potency of cancer immunotherapy. -other hsa-mir-19a Glioblastoma 25677619 Our findings suggest that engineering of tumor antigen-specific CD8(+) T-cells to express miR-17-92 may improve the potency of cancer immunotherapy. -other hsa-mir-19b-1 Glioblastoma 25677619 Our findings suggest that engineering of tumor antigen-specific CD8(+) T-cells to express miR-17-92 may improve the potency of cancer immunotherapy. -other hsa-mir-20a Glioblastoma 25677619 Our findings suggest that engineering of tumor antigen-specific CD8(+) T-cells to express miR-17-92 may improve the potency of cancer immunotherapy. -other hsa-mir-92-1 Glioblastoma 25677619 Our findings suggest that engineering of tumor antigen-specific CD8(+) T-cells to express miR-17-92 may improve the potency of cancer immunotherapy. -other hsa-mir-193b "Squamous Cell Carcinoma, Head and Neck" 25677760 Alteration in miR-193b expression level does not show any significant association with cancer survival. -other hsa-mir-206 Muscle Diseases [unspecific] 25678853 "MiR-206, a key modulator of skeletal muscle development and disease." -other hsa-mir-211 "Carcinoma, Breast, Triple Negative" 25680404 "MicroRNA-211, a direct negative regulator of CDC25B expression, inhibits triple-negative breast cancer cells' growth and migration." -other hsa-mir-135a Breast Neoplasms 25680412 This study aimed to screen potential microRNAs (miRNAs) and genes related to human primary breast cancer. -other hsa-mir-139 Breast Neoplasms 25680412 This study aimed to screen potential microRNAs (miRNAs) and genes related to human primary breast cancer. -other hsa-mir-375 Breast Neoplasms 25680412 This study aimed to screen potential microRNAs (miRNAs) and genes related to human primary breast cancer. -other hsa-mir-592 Breast Neoplasms 25680412 This study aimed to screen potential microRNAs (miRNAs) and genes related to human primary breast cancer. -other hsa-mir-9 Breast Neoplasms 25680412 This study aimed to screen potential microRNAs (miRNAs) and genes related to human primary breast cancer. -other hsa-mir-603 Glioma 25681036 miR-603 promotes glioma cell growth via Wnt/¦Â-catenin pathway by inhibiting WIF1 and CTNNBIP1. -other hsa-mir-130a Pulmonary Hypertension 25681685 These data suggest that miRNA family miR-130 plays an important role in the repression of CDKN1A by hypoxia.miR-130 enhances hypoxia-induced smooth muscle proliferation and might be involved in the development of right ventricular hypertrophy and vascular remodeling in pulmonary hypertension. -other hsa-mir-31 Wounds and Injuries [unspecific] 25685928 MicroRNA-31 Promotes Skin Wound Healing by Enhancing Keratinocyte Proliferation and Migration. -other hsa-mir-455 Melanoma 25686251 Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis. -other hsa-mir-512 "Carcinoma, Lung, Non-Small-Cell" 25687035 Inhibition of RAC1-GEF DOCK3 by miR-512-3p contributes to suppression of metastasis in non-small cell lung cancer. -other hsa-mir-21 Vascular Hypertrophy 25689721 Ursolic acid down-regulated miRNA-21 expression and up-regulated PTEN protein and mRNA expression. -other hsa-mir-30 Muscle Diseases [unspecific] 25689854 These findings indicate that the miR-30 family may be an interesting biomarker of perturbed muscle homeostasis and muscle disease. -other hsa-mir-150 Immune System Disease [unspecific] 25690461 Our current studies characterized TsF as regulatory miRNA-150 carried by T suppressor cell-derived exosomes that are antigen specific due to a surface coat of IgM antibody light chains produced by B1a cells. -other hsa-mir-139 Neoplasms [unspecific] 25691250 MiR-139-5p: promising biomarker for cancer. -other hsa-mir-205 Lung Neoplasms 25695220 MiR-205 and MiR-375 microRNA assays to distinguish squamous cell carcinoma from adenocarcinoma in lung cancer biopsies. -other hsa-mir-375 Lung Neoplasms 25695220 MiR-205 and MiR-375 microRNA assays to distinguish squamous cell carcinoma from adenocarcinoma in lung cancer biopsies. -other hsa-mir-663 Alzheimer Disease 25695604 Our results indicate that AICD has a novel role in suppression of neuronal differentiation via transcriptional regulation of miR-663 in human neural stem cells. -other hsa-mir-27b Liver Neoplasms 25698578 we propose that miR-27b synergizes with anticancer drugs in a defined subgroup of liver and kidney cancer patients. -other hsa-mir-155 Keratitis 25700796 Role of miR-155 in the pathogenesis of herpetic stromal keratitis. -other hsa-mir-185 "Carcinoma, Renal Cell, Clear-Cell" 25700976 "Our results suggest that the miR-185, as a tumor suppressor, plays a pivotal role by inhibiting VEGFA in VHL-inactivated ccRCC." -other hsa-mir-126 Obesity 25701361 Our study provides a bioinformatic basis for further research of molecular mechanism in obesity. -other hsa-mir-16 Obesity 25701361 Our study provides a bioinformatic basis for further research of molecular mechanism in obesity. -other hsa-mir-425 Obesity 25701361 Our study provides a bioinformatic basis for further research of molecular mechanism in obesity. -other hsa-mir-634 Obesity 25701361 Our study provides a bioinformatic basis for further research of molecular mechanism in obesity. -other hsa-mir-143 "Carcinoma, Nasopharyngeal" 25701793 Identification of miR-143 as a tumour suppressor in nasopharyngeal carcinoma based on microRNA expression profiling. -other hsa-mir-100 Gastric Neoplasms 25703026 The role of miR-100-mediated Notch pathway in apoptosis of gastric tumor cells. -other hsa-let-7d Obesity 25704235 Nonivamide enhances miRNA let-7d expression and decreases adipogenesis PPARγ expression in 3T3-L1 cells. -other hsa-mir-708 "Leukemia, Lymphocytic, Chronic, B-Cell" 25704289 Epigenetic silencing of miR-708 enhances NF-¦ÊB signaling in chronic lymphocytic leukemia. -other hsa-mir-128 "Carcinoma, Hepatocellular" 25704921 Suppression of CYP2C9 by microRNA hsa-miR-128-3p in human liver cells and association with hepatocellular carcinoma. -other hsa-mir-31 Liver Injury 25706292 "Both compounds also down-regulated miR-31, which directly targets caspase-2 and influences apoptosis in SEB-activated cells." -other hsa-mir-199a Atrial Fibrillation 25706326 Our combined transcriptomic analysis and miRNA microarray study of atrial samples from pAF patients revealed novel pathways and miRNA-mRNA regulations that may be relevant in the development of pAF. Future studies are required to investigate the potential involvement of the gonadotropin releasing hormone receptor and p53 pathways in AF pathogenesis. -other hsa-mir-21 Breast Neoplasms 25706383 "Our results indicated that miR-21 can predict unfavorable prognoses in breast cancer patients, especially in Asians." -other hsa-mir-17 Hepatitis C Virus Infection 25707620 Our rule discovery method is useful for integrating binding information and expression profile for identifying HCV miRNA-mRNA regulatory modules and can be applied to the study of the expression profiles of other complex human diseases. -other hsa-mir-557 Hepatitis C Virus Infection 25707620 Our rule discovery method is useful for integrating binding information and expression profile for identifying HCV miRNA-mRNA regulatory modules and can be applied to the study of the expression profiles of other complex human diseases. -other hsa-mir-765 Hepatitis C Virus Infection 25707620 Our rule discovery method is useful for integrating binding information and expression profile for identifying HCV miRNA-mRNA regulatory modules and can be applied to the study of the expression profiles of other complex human diseases. -other hsa-mir-153 "Carcinoma, Hepatocellular" 25708809 MicroRNA-153 promotes Wnt/¦Â-catenin activation in hepatocellular carcinoma through suppression of WWOX. -other hsa-mir-223 "Leukemia, Myeloid, Acute" 25710580 De Novo Acute Myeloid Leukemia in Adults: Suppression of MicroRNA-223 is Independent of LMO2 Protein Expression BUT Associate With Adverse Cytogenetic Profile and Undifferentiated Blast Morphology. -other hsa-let-7f Obesity 25710930 "genes modulated in RO-treated cells were found to be validated miRNAs targets, such as let-7f-1, miR-17, and miR-143." -other hsa-mir-27a Colorectal Carcinoma 25712055 Novel Evidence for Curcumin and Boswellic Acid-Induced Chemoprevention through Regulation of miR-34a and miR-27a in Colorectal Cancer. -other hsa-mir-34a Colorectal Carcinoma 25712055 Novel Evidence for Curcumin and Boswellic Acid-Induced Chemoprevention through Regulation of miR-34a and miR-27a in Colorectal Cancer. -other hsa-mir-335 "Carcinoma, Cervical" 25712373 MicroRNA-335 represents an independent prognostic marker in cervical cancer. -other hsa-mir-30a "Carcinoma, Renal Cell" 25712526 MiRNA-30a-mediated autophagy inhibition sensitizes renal cell carcinoma cells to sorafenib. -other hsa-mir-199a "Carcinoma, Hepatocellular" 25714015 "Increase of miR-199a-5p by protoporphyrin IX, a photocatalyzer, directly inhibits E2F3, sensitizing mesenchymal tumor cells to anti-cancer agents." -other hsa-mir-372 "Squamous Cell Carcinoma, Head and Neck" 25714028 miR-372 inhibits p62 in head and neck squamous cell carcinoma in vitro and in vivo. -other hsa-mir-148a Adenovirus Infection 25714032 "Thus, miRNA-control of late proteins constitutes a novel strategy to provide selectivity to adenoviruses." -other hsa-let-7 "Carcinoma, Lung, Non-Small-Cell" 25714397 Combinatorial Action of MicroRNAs let-7 and miR-34 Effectively Synergizes with Erlotinib to Suppress Non-small Cell Lung Cancer Cell Proliferation. -other hsa-mir-34 "Carcinoma, Lung, Non-Small-Cell" 25714397 Combinatorial Action of MicroRNAs let-7 and miR-34 Effectively Synergizes with Erlotinib to Suppress Non-small Cell Lung Cancer Cell Proliferation. -other hsa-mir-133a "Carcinoma, Hepatocellular" 25714665 These findings for the first time demonstrated that the involvement of miR-133a and miR-326 in MDR is mediated by ABCC1 in hepatocellular carcinoma cell line HepG2 and suggested that miR-133a and miR-326 may be efficient agents for preventing and reversing ADM resistance in cancer cells. -other hsa-mir-326 "Carcinoma, Hepatocellular" 25714665 These findings for the first time demonstrated that the involvement of miR-133a and miR-326 in MDR is mediated by ABCC1 in hepatocellular carcinoma cell line HepG2 and suggested that miR-133a and miR-326 may be efficient agents for preventing and reversing ADM resistance in cancer cells. -other hsa-mir-424 Neoplasms [unspecific] 25716682 TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation. -other hsa-mir-27a Liver Diseases [unspecific] 25716995 our study demonstrates the regulatory role of miR-27a in alcohol-induced monocyte activation and polarization. -other hsa-let-7c Human Immunodeficiency Virus Infection 25717002 "Our data suggest that HIV-1 exploits the host miRNA cellular systems in order to block the innate inhibition mechanism, allowing a more efficient infection process." -other hsa-mir-124a Human Immunodeficiency Virus Infection 25717002 "Our data suggest that HIV-1 exploits the host miRNA cellular systems in order to block the innate inhibition mechanism, allowing a more efficient infection process." -other hsa-mir-34a Human Immunodeficiency Virus Infection 25717002 "Our data suggest that HIV-1 exploits the host miRNA cellular systems in order to block the innate inhibition mechanism, allowing a more efficient infection process." -other hsa-mir-21 "Carcinoma, Hepatocellular" 25720799 High-Mobility Group Box 1 Promotes Hepatocellular Carcinoma Progression through miR-21-Mediated Matrix Metalloproteinase Activity. -other hsa-let-7a Breast Neoplasms 25722304 These results point to using high levels of tRNA-derived small RNA fragments in combination with known miR signatures of tumors to distinguish tumor-derived EVs in circulation from EVs derived from other cell sources. Such biomarkers would be unique to the EVs where high abundances of tRNA fragments are amplified with respect to their cellular levels. -other hsa-mir-125b Breast Neoplasms 25722304 These results point to using high levels of tRNA-derived small RNA fragments in combination with known miR signatures of tumors to distinguish tumor-derived EVs in circulation from EVs derived from other cell sources. Such biomarkers would be unique to the EVs where high abundances of tRNA fragments are amplified with respect to their cellular levels. -other hsa-mir-1274b Breast Neoplasms 25722304 These results point to using high levels of tRNA-derived small RNA fragments in combination with known miR signatures of tumors to distinguish tumor-derived EVs in circulation from EVs derived from other cell sources. Such biomarkers would be unique to the EVs where high abundances of tRNA fragments are amplified with respect to their cellular levels. -other hsa-mir-205 Breast Neoplasms 25722304 These results point to using high levels of tRNA-derived small RNA fragments in combination with known miR signatures of tumors to distinguish tumor-derived EVs in circulation from EVs derived from other cell sources. Such biomarkers would be unique to the EVs where high abundances of tRNA fragments are amplified with respect to their cellular levels. -other hsa-mir-21 Breast Neoplasms 25722304 These results point to using high levels of tRNA-derived small RNA fragments in combination with known miR signatures of tumors to distinguish tumor-derived EVs in circulation from EVs derived from other cell sources. Such biomarkers would be unique to the EVs where high abundances of tRNA fragments are amplified with respect to their cellular levels. -other hsa-mir-720 Breast Neoplasms 25722304 These results point to using high levels of tRNA-derived small RNA fragments in combination with known miR signatures of tumors to distinguish tumor-derived EVs in circulation from EVs derived from other cell sources. Such biomarkers would be unique to the EVs where high abundances of tRNA fragments are amplified with respect to their cellular levels. -other hsa-mir-630 "Carcinoma, Hepatocellular" 25731670 These results suggest that miR-630 is associated with tumor progression of hepatocellular carcinoma and may be a potential prognosis indicator. -other hsa-mir-526b Breast Neoplasms 25733698 COX-2 Elevates Oncogenic miR-526b in Breast Cancer by EP4 Activation. -other hsa-mir-324 "Carcinoma, Nasopharyngeal" 25735100 The loss of miRNA-324-3p and ectopic WNT2B might co-induce the initiation and progression of NPC. -other hsa-mir-222 Breast Neoplasms 25735339 Ginsenoside Rh2 differentially mediates microRNA expression to prevent chemoresistance of breast cancer. -other hsa-mir-29a Breast Neoplasms 25735339 Ginsenoside Rh2 differentially mediates microRNA expression to prevent chemoresistance of breast cancer. -other hsa-mir-34a Breast Neoplasms 25735339 Ginsenoside Rh2 differentially mediates microRNA expression to prevent chemoresistance of breast cancer. -other hsa-mir-21 Breast Neoplasms 25735723 MiR-21 controls in situ expansion of CCR6 regulatory T cells through PTEN/AKT pathway in breast cancer. -other hsa-mir-205 Glioblastoma 25736407 Pterostilbene suppressed irradiation-resistant glioma stem cells by modulating GRP78/miR-205 axis. -other hsa-mir-24 "Diabetes Mellitus, Type 2" 25737017 Pioglitazone increases circulating microRNA-24 with decrease in coronary neointimal hyperplasia in type 2 diabetic patients- optical coherence tomography analysis. -other hsa-mir-29b Uterine Corpus Choriocarcinoma 25738313 BAG3 increases the invasiveness of uterine corpus carcinoma cells by suppressing miR-29b and enhancing MMP2 expression. -other hsa-mir-10b Glioblastoma 25738367 MicroRNA-10b inhibition reduces E2F1-mediated transcription and miR-15/16 activity in glioblastoma. -other hsa-mir-15 Glioblastoma 25738367 MicroRNA-10b inhibition reduces E2F1-mediated transcription and miR-15/16 activity in glioblastoma. -other hsa-mir-16 Glioblastoma 25738367 MicroRNA-10b inhibition reduces E2F1-mediated transcription and miR-15/16 activity in glioblastoma. -other hsa-mir-182 "Carcinoma, Hepatocellular" 25739014 "A pleiotropic effect of the single clustered hepatic metastamiRs miR-96-5p and miR-182-5p on insulin-like growth factor II, insulin-like growth factor-1 receptor and insulin-like growth factor-binding protein-3 in hepatocellular carcinoma." -other hsa-mir-133a Arteriosclerosis Obliterans 25740337 MicroRNA-133a in the Development of Arteriosclerosis Obliterans. -other hsa-mir-216b "Carcinoma, Hepatocellular" 25741595 MiR-216b is involved in pathogenesis and progression of hepatocellular carcinoma through HBx-miR-216b-IGF2BP2 signaling pathway. -other hsa-mir-186 "Adenocarcinoma, Pancreatic Ductal" 25742499 miR-186 and 326 predict the prognosis of pancreatic ductal adenocarcinoma and affect the proliferation and migration of cancer cells. -other hsa-mir-326 "Adenocarcinoma, Pancreatic Ductal" 25742499 miR-186 and 326 predict the prognosis of pancreatic ductal adenocarcinoma and affect the proliferation and migration of cancer cells. -other hsa-mir-155 Breast Neoplasms 25744731 Role of miR-155 in drug resistance of breast cancer. -other hsa-mir-33a Lipid Metabolism Disorder 25744742 "we describe the current understanding of the function of miR-33a/b in lipid homeostasis, focusing on the thrifty aspect." -other hsa-mir-33b Lipid Metabolism Disorder 25744742 "we describe the current understanding of the function of miR-33a/b in lipid homeostasis, focusing on the thrifty aspect." -other hsa-mir-200c Breast Neoplasms 25746005 "Expression of miR-200c in claudin-low breast cancer alters stem cell functionality, enhances chemosensitivity and reduces metastatic potential." -other hsa-mir-1270 Inflammation 25746225 This coordinated regulatory architecture suggests a vital function for the innate immune system in maintaining precise physiological type I IFN levels via post-transcriptional regulatory mechanisms. -other hsa-mir-141 "Squamous Cell Carcinoma, Lung" 25746592 MicroRNA-141 is a biomarker for progression of squamous cell carcinoma and adenocarcinoma of the lung: clinical analysis of 125 patients. -other hsa-mir-29a "Lymphoma, Burkitt" 25746661 "Deregulation of DNMT1, DNMT3B and miR-29s in Burkitt lymphoma suggests novel contribution for disease pathogenesis." -other hsa-mir-29b "Lymphoma, Burkitt" 25746661 "Deregulation of DNMT1, DNMT3B and miR-29s in Burkitt lymphoma suggests novel contribution for disease pathogenesis." -other hsa-mir-29c "Lymphoma, Burkitt" 25746661 "Deregulation of DNMT1, DNMT3B and miR-29s in Burkitt lymphoma suggests novel contribution for disease pathogenesis." -other hsa-mir-17 "Carcinoma, Thyroid, Follicular" 25748447 Sphingosine-1-phosphate induces the migration of thyroid follicular carcinoma cells through the microRNA-17/PTK6/ERK1/2 pathway. -other hsa-mir-27a Osteosarcoma 25749032 miR-27a and miR-27a* contribute to metastatic properties of osteosarcoma cells. -other hsa-mir-16 Prostate Neoplasms 25750034 This study highlights that commonly used endogenous controls can be responsive to radiation and validation is required prior to gene/miRNAs expression studies. -other hsa-mir-331 "Carcinoma, Hepatocellular" 25750939 This provided useful information in exploring the mechanism of HCC induced by HBV infection. -other hsa-mir-204 "Carcinoma, Nasopharyngeal" 25752113 Clinical significance of miRNA-204 in nasopharyngeal carcinoma. -other hsa-mir-124 Glioblastoma 25753094 Gap Junctions Enhance the Antiproliferative Effect of MicroRNA-124-3p in Glioblastoma Cells. -other hsa-mir-223 Hematologic Neoplasms 25753223 "C/EBPα interacts with AP-1 proteins to bind hybrid DNA elements during monopoiesis, and induction of Gfi-1, C/EBPε, KLF5, and miR-223 by C/EBPα enables granulopoiesis." -other hsa-mir-142 Endometrial Stromal Sarcoma 25754227 miR-142-3p is a novel regulator of cell viability and proinflammatory signalling in endometrial stroma cells. -other hsa-mir-1179 "Squamous Cell Carcinoma, Esophageal" 25755718 miR-1179 promotes cell invasion through SLIT2/ROBO1 axis in esophageal squamous cell carcinoma. -other hsa-mir-18a "Carcinoma, Lung, Non-Small-Cell" 25755757 Effect of miR-18a overexpression on the radiosensitivity of non-small cell lung cancer. -other hsa-let-7a Pleural Mesothelioma 25756049 Specific microRNAs and mRNAs may have diagnostic utility in differentiating patients with malignant pleural mesothelioma from benign asbestos-related pleural effusion. These studies may be particularly helpful in patients who reside in a region with a high incidence of mesothelioma. -other hsa-mir-125a Pleural Mesothelioma 25756049 Specific microRNAs and mRNAs may have diagnostic utility in differentiating patients with malignant pleural mesothelioma from benign asbestos-related pleural effusion. These studies may be particularly helpful in patients who reside in a region with a high incidence of mesothelioma. -other hsa-mir-320 Pleural Mesothelioma 25756049 Specific microRNAs and mRNAs may have diagnostic utility in differentiating patients with malignant pleural mesothelioma from benign asbestos-related pleural effusion. These studies may be particularly helpful in patients who reside in a region with a high incidence of mesothelioma. -other hsa-mir-484 Pleural Mesothelioma 25756049 Specific microRNAs and mRNAs may have diagnostic utility in differentiating patients with malignant pleural mesothelioma from benign asbestos-related pleural effusion. These studies may be particularly helpful in patients who reside in a region with a high incidence of mesothelioma. -other hsa-mir-1204 "Carcinoma, Nasopharyngeal" 25756509 MiR-1204 sensitizes nasopharyngeal carcinoma cells to paclitaxel both in vitro and in vivo. -other hsa-let-7a Alzheimer Disease 25759134 "we demonstrate in detail the power of DNA/RNA chimera/AgNC probes in detecting two human miRNAs,let-7a and miR-200c. The DNA/RNA chimera-based probes are highly efficient to determine the level of miRNAs in several human cell lines." -other hsa-let-7a Asthma 25759134 "we demonstrate in detail the power of DNA/RNA chimera/AgNC probes in detecting two human miRNAs,let-7a and miR-200c. The DNA/RNA chimera-based probes are highly efficient to determine the level of miRNAs in several human cell lines." -other hsa-let-7a Autoimmune Diseases [unspecific] 25759134 "we demonstrate in detail the power of DNA/RNA chimera/AgNC probes in detecting two human miRNAs,let-7a and miR-200c. The DNA/RNA chimera-based probes are highly efficient to determine the level of miRNAs in several human cell lines." -other hsa-let-7a Cardiovascular Diseases [unspecific] 25759134 "we demonstrate in detail the power of DNA/RNA chimera/AgNC probes in detecting two human miRNAs,let-7a and miR-200c. The DNA/RNA chimera-based probes are highly efficient to determine the level of miRNAs in several human cell lines." -other hsa-let-7a Diabetes Mellitus 25759134 "we demonstrate in detail the power of DNA/RNA chimera/AgNC probes in detecting two human miRNAs,let-7a and miR-200c. The DNA/RNA chimera-based probes are highly efficient to determine the level of miRNAs in several human cell lines." -other hsa-let-7a Neoplasms [unspecific] 25759134 "we demonstrate in detail the power of DNA/RNA chimera/AgNC probes in detecting two human miRNAs,let-7a and miR-200c. The DNA/RNA chimera-based probes are highly efficient to determine the level of miRNAs in several human cell lines." -other hsa-mir-200c Alzheimer Disease 25759134 "we demonstrate in detail the power of DNA/RNA chimera/AgNC probes in detecting two human miRNAs,let-7a and miR-200c. The DNA/RNA chimera-based probes are highly efficient to determine the level of miRNAs in several human cell lines." -other hsa-mir-200c Asthma 25759134 "we demonstrate in detail the power of DNA/RNA chimera/AgNC probes in detecting two human miRNAs,let-7a and miR-200c. The DNA/RNA chimera-based probes are highly efficient to determine the level of miRNAs in several human cell lines." -other hsa-mir-200c Autoimmune Diseases [unspecific] 25759134 "we demonstrate in detail the power of DNA/RNA chimera/AgNC probes in detecting two human miRNAs,let-7a and miR-200c. The DNA/RNA chimera-based probes are highly efficient to determine the level of miRNAs in several human cell lines." -other hsa-mir-200c Cardiovascular Diseases [unspecific] 25759134 "we demonstrate in detail the power of DNA/RNA chimera/AgNC probes in detecting two human miRNAs,let-7a and miR-200c. The DNA/RNA chimera-based probes are highly efficient to determine the level of miRNAs in several human cell lines." -other hsa-mir-200c Diabetes Mellitus 25759134 "we demonstrate in detail the power of DNA/RNA chimera/AgNC probes in detecting two human miRNAs,let-7a and miR-200c. The DNA/RNA chimera-based probes are highly efficient to determine the level of miRNAs in several human cell lines." -other hsa-mir-200c Neoplasms [unspecific] 25759134 "we demonstrate in detail the power of DNA/RNA chimera/AgNC probes in detecting two human miRNAs,let-7a and miR-200c. The DNA/RNA chimera-based probes are highly efficient to determine the level of miRNAs in several human cell lines." -other hsa-mir-106a "Carcinoma, Hepatocellular" 25760076 The PDGF-D/miR-106a/Twist1 pathway orchestrates epithelial-mesenchymal transition in gemcitabine resistance hepatoma cells. -other hsa-mir-449a Neoplasms [unspecific] 25760387 microRNA-449a functions as a tumor suppressor in neuroblastoma through inducing cell differentiation and cell cycle arrest. -other hsa-mir-155 Atopic Dermatitis 25761610 MicroRNA-155 may be involved in the pathogenesis of atopic dermatitis by modulating the differentiation and function of T helper type 17 (Th17) cells. -other hsa-mir-34a "Squamous Cell Carcinoma, Head and Neck" 25762634 MiR-34a suppresses amphiregulin and tumor metastatic potential of head and neck squamous cell carcinoma (HNSCC). -other hsa-mir-125b Heart Failure 25763857 "Measured microRNA profiles did not separate the samples according to the clinical features of the patients. However, several previously identified heart failure marker microRNAs were detected. The pericardial fluid microRNA profile appeared to be a result of an active and selective secretory process indicating that microRNAs may act as paracrine signalling factors by mediating the local crosstalk between cardiac cells." -other hsa-mir-16 Heart Failure 25763857 "Measured microRNA profiles did not separate the samples according to the clinical features of the patients. However, several previously identified heart failure marker microRNAs were detected. The pericardial fluid microRNA profile appeared to be a result of an active and selective secretory process indicating that microRNAs may act as paracrine signalling factors by mediating the local crosstalk between cardiac cells." -other hsa-mir-21 Heart Failure 25763857 "Measured microRNA profiles did not separate the samples according to the clinical features of the patients. However, several previously identified heart failure marker microRNAs were detected. The pericardial fluid microRNA profile appeared to be a result of an active and selective secretory process indicating that microRNAs may act as paracrine signalling factors by mediating the local crosstalk between cardiac cells." -other hsa-mir-451a Heart Failure 25763857 "Measured microRNA profiles did not separate the samples according to the clinical features of the patients. However, several previously identified heart failure marker microRNAs were detected. The pericardial fluid microRNA profile appeared to be a result of an active and selective secretory process indicating that microRNAs may act as paracrine signalling factors by mediating the local crosstalk between cardiac cells." -other hsa-mir-128 "Squamous Cell Carcinoma, Head and Neck" 25764126 Functions of MiRNA-128 on the regulation of head and neck squamous cell carcinoma growth and apoptosis. -other hsa-mir-577 Glioblastoma 25764520 miR-577 inhibits glioblastoma tumor growth via the Wnt signaling pathway. -other hsa-mir-19b Atherosclerosis 25765596 The present study demonstrates that Dgn enhances ABCA1-dependent cholesterol efflux and inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression. -other hsa-mir-23b Gastric Neoplasms 25765901 Reciprocal repression between TUSC7 and miR-23b in gastric cancer. -other hsa-mir-122 Hepatitis C Virus Infection 25768906 Hepatitis C virus RNA functionally sequesters miR-122. -other hsa-mir-33a Obesity 25769350 "Deregulation of miR-33 and miR-122, as major regulators of lipid metabolism in liver, has been related to obesity and metabolic syndrome." -other hsa-mir-338 Kideny Transplant Rejection 25769569 miR-338-5p is closely correlated with the procedure of renal allograft antibody-mediated rejection. -other hsa-mir-125b "Carcinoma, Lung, Non-Small-Cell" 25772251 Matrix metalloproteinase 13: a potential intermediate between low expression of microRNA-125b and increasing metastatic potential of non-small cell lung cancer. -other hsa-mir-27a "Carcinoma, Lung, Non-Small-Cell" 25773791 Rs895819 within miR-27a might be involved in development of non small cell lung cancer in the Chinese Han population. -other hsa-mir-143 "Carcinoma, Renal Cell, Clear-Cell" 25776476 our data support the notion that sunitinib and everolimus are able to directly induce cell death in renal cancer cells and simultaneously affect the expression levels of their apoptosis-related microRNAs and BCL2 family members upon this process. -other hsa-mir-145 "Carcinoma, Renal Cell, Clear-Cell" 25776476 our data support the notion that sunitinib and everolimus are able to directly induce cell death in renal cancer cells and simultaneously affect the expression levels of their apoptosis-related microRNAs and BCL2 family members upon this process. -other hsa-mir-15a "Carcinoma, Renal Cell, Clear-Cell" 25776476 our data support the notion that sunitinib and everolimus are able to directly induce cell death in renal cancer cells and simultaneously affect the expression levels of their apoptosis-related microRNAs and BCL2 family members upon this process. -other hsa-mir-16 "Carcinoma, Renal Cell, Clear-Cell" 25776476 our data support the notion that sunitinib and everolimus are able to directly induce cell death in renal cancer cells and simultaneously affect the expression levels of their apoptosis-related microRNAs and BCL2 family members upon this process. -other hsa-mir-182 "Carcinoma, Renal Cell, Clear-Cell" 25776476 our data support the notion that sunitinib and everolimus are able to directly induce cell death in renal cancer cells and simultaneously affect the expression levels of their apoptosis-related microRNAs and BCL2 family members upon this process. -other hsa-mir-183 "Carcinoma, Renal Cell, Clear-Cell" 25776476 our data support the notion that sunitinib and everolimus are able to directly induce cell death in renal cancer cells and simultaneously affect the expression levels of their apoptosis-related microRNAs and BCL2 family members upon this process. -other hsa-mir-96 "Carcinoma, Renal Cell, Clear-Cell" 25776476 our data support the notion that sunitinib and everolimus are able to directly induce cell death in renal cancer cells and simultaneously affect the expression levels of their apoptosis-related microRNAs and BCL2 family members upon this process. -other hsa-mir-150 Prostate Neoplasms 25778313 miR-150 is a factor of survival in prostate cancer patients. -other hsa-mir-125a Androgenetic Alopecia 25778683 "These results demonstrated that the expression of miRNA was altered in the DHT-treated nHDPCs and suggest the potential mechanisms of DHT-induced cell growth repression, cell cycle arrest, cell death, senescence and induction of ROS." -other hsa-mir-485 Androgenetic Alopecia 25778683 "These results demonstrated that the expression of miRNA was altered in the DHT-treated nHDPCs and suggest the potential mechanisms of DHT-induced cell growth repression, cell cycle arrest, cell death, senescence and induction of ROS." -other hsa-mir-7 Androgenetic Alopecia 25778683 "These results demonstrated that the expression of miRNA was altered in the DHT-treated nHDPCs and suggest the potential mechanisms of DHT-induced cell growth repression, cell cycle arrest, cell death, senescence and induction of ROS." -other hsa-let-7b Neuroblastoma 25779425 Enterovirus 71 induces apoptosis of SH-SY5Y human neuroblastoma cells through stimulation of endogenous microRNA let-7b expression. -other hsa-mir-133a Gastric Neoplasms 25780292 Tumor suppressor role of miR-133a in gastric cancer by repressing IGF1R. -other hsa-mir-494 Neoplasms [unspecific] 25781916 "Specifically we have linked miR-134, miR-145, miR-146b-5p, miR-432 and miR-494 to the regulation of both apoptotic and anti-apoptotic genes expressed as a function of EGF treatment." -other hsa-mir-21 Breast Neoplasms 25784176 "3,6-Dihydroxyflavone Suppresses Breast Carcinogenesis by Epigenetically Regulating miR-34a and miR-21." -other hsa-mir-34a Breast Neoplasms 25784176 "3,6-Dihydroxyflavone Suppresses Breast Carcinogenesis by Epigenetically Regulating miR-34a and miR-21." -other hsa-mir-218-1 Hirschsprung Disease 25786906 SLIT2/ROBO1-miR-218-1-RET/PLAG1: a new disease pathway involved in Hirschsprung's disease. -other hsa-mir-16 Neoplasms [unspecific] 25787082 "In addition, we observed significantly reduced expression of microRNAs (miRNAs) including miR-16 and miR-19b, which are known to be significantly reduced in the semen of infertile men." -other hsa-mir-122 Chronic Hepatitis B 25788377 Clinical significance of circulating miR-122 in patients with dual chronic hepatitis B and C virus infection. -other hsa-let-7b Influenza 25788763 This approach provides an additional layer of biosafety and thus has great potential for the application in the rational development of safer and more effective influenza viral vaccines. -other hsa-mir-200a Liver Injury 25789565 our data indicate that the p53-dependent expression of miR-200a-3p promotes cell death by inhibiting a p38/p53/miR-200 feedback loop. -other hsa-mir-34a Breast Neoplasms 25789847 "Phytochemical regulation of the tumor suppressive microRNA, miR-34a, by p53-dependent and independent responses in human breast cancer cells." -other hsa-mir-205 "Carcinoma, Breast, Triple Negative" 25792283 Pterostilbene inhibits triple-negative breast cancer metastasis via inducing microRNA-205 expression and negatively modulates epithelial-to-mesenchymal transition. -other hsa-mir-486 "Adenocarcinoma, Gastric" 25793394 Expression and prognostic value of miR-486-5p in patients with gastric adenocarcinoma. -other hsa-mir-221 Ischemic Diseases [unspecific] 25796380 "Moreover, exosomes from MSCs and MSCs treated by BYHWD induced elevated microRNA (miRNA)-126 expression and reduced miR-221 and miR-222 expression." -other hsa-mir-222 Ischemic Diseases [unspecific] 25796380 "Moreover, exosomes from MSCs and MSCs treated by BYHWD induced elevated microRNA (miRNA)-126 expression and reduced miR-221 and miR-222 expression." -other hsa-mir-150 "Leukemia, Lymphoblastic, Acute" 25796601 "This study not only identifies differences in the pathways and networks of acute lymphocytic leukemia (ALL) relative to normal lymphocytes, but also identifies unique functional characteristics of lymphoid cells and distinct gene expression patterns during lymphoid development. The discovery of leukemia-related miRNAs may provide meaningful insights into the biology of the disease." -other hsa-mir-17 "Leukemia, Lymphoblastic, Acute" 25796601 "This study not only identifies differences in the pathways and networks of acute lymphocytic leukemia (ALL) relative to normal lymphocytes, but also identifies unique functional characteristics of lymphoid cells and distinct gene expression patterns during lymphoid development. The discovery of leukemia-related miRNAs may provide meaningful insights into the biology of the disease." -other hsa-mir-18 "Leukemia, Lymphoblastic, Acute" 25796601 "This study not only identifies differences in the pathways and networks of acute lymphocytic leukemia (ALL) relative to normal lymphocytes, but also identifies unique functional characteristics of lymphoid cells and distinct gene expression patterns during lymphoid development. The discovery of leukemia-related miRNAs may provide meaningful insights into the biology of the disease." -other hsa-mir-18a "Leukemia, Lymphoblastic, Acute" 25796601 "This study not only identifies differences in the pathways and networks of acute lymphocytic leukemia (ALL) relative to normal lymphocytes, but also identifies unique functional characteristics of lymphoid cells and distinct gene expression patterns during lymphoid development. The discovery of leukemia-related miRNAs may provide meaningful insights into the biology of the disease." -other hsa-mir-19a "Leukemia, Lymphoblastic, Acute" 25796601 "This study not only identifies differences in the pathways and networks of acute lymphocytic leukemia (ALL) relative to normal lymphocytes, but also identifies unique functional characteristics of lymphoid cells and distinct gene expression patterns during lymphoid development. The discovery of leukemia-related miRNAs may provide meaningful insights into the biology of the disease." -other hsa-mir-19b-1 "Leukemia, Lymphoblastic, Acute" 25796601 "This study not only identifies differences in the pathways and networks of acute lymphocytic leukemia (ALL) relative to normal lymphocytes, but also identifies unique functional characteristics of lymphoid cells and distinct gene expression patterns during lymphoid development. The discovery of leukemia-related miRNAs may provide meaningful insights into the biology of the disease." -other hsa-mir-20a "Leukemia, Lymphoblastic, Acute" 25796601 "This study not only identifies differences in the pathways and networks of acute lymphocytic leukemia (ALL) relative to normal lymphocytes, but also identifies unique functional characteristics of lymphoid cells and distinct gene expression patterns during lymphoid development. The discovery of leukemia-related miRNAs may provide meaningful insights into the biology of the disease." -other hsa-mir-222 "Leukemia, Lymphoblastic, Acute" 25796601 "This study not only identifies differences in the pathways and networks of acute lymphocytic leukemia (ALL) relative to normal lymphocytes, but also identifies unique functional characteristics of lymphoid cells and distinct gene expression patterns during lymphoid development. The discovery of leukemia-related miRNAs may provide meaningful insights into the biology of the disease." -other hsa-mir-92-1 "Leukemia, Lymphoblastic, Acute" 25796601 "This study not only identifies differences in the pathways and networks of acute lymphocytic leukemia (ALL) relative to normal lymphocytes, but also identifies unique functional characteristics of lymphoid cells and distinct gene expression patterns during lymphoid development. The discovery of leukemia-related miRNAs may provide meaningful insights into the biology of the disease." -other hsa-mir-92a "Leukemia, Lymphoblastic, Acute" 25796601 "This study not only identifies differences in the pathways and networks of acute lymphocytic leukemia (ALL) relative to normal lymphocytes, but also identifies unique functional characteristics of lymphoid cells and distinct gene expression patterns during lymphoid development. The discovery of leukemia-related miRNAs may provide meaningful insights into the biology of the disease." -other hsa-mir-200a "Carcinoma, Hepatocellular" 25797260 MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2. -other hsa-mir-432 "Carcinoma, Hepatocellular" 25797263 Downregulation of miR-432 activates Wnt/¦Â-catenin signaling and promotes human hepatocellular carcinoma proliferation. -other hsa-let-7e Cystic Fibrosis 25800681 "Ingenuity Pathway Analysis indicated that hsa-miR-99b and hsa-miR-125a could be associated with the phenotypes manifested by p.F508del patients. Here we provide novel elements in the mechanism of hsa-miR-99b and hsa-miR-125a biogenesis, and for the role of CFTR and DeltaF508-CFTR on the expression of this miRNA cluster. These findings augment existing data implicating miRNAs as putative CF modifiers." -other hsa-mir-125a Cystic Fibrosis 25800681 "Ingenuity Pathway Analysis indicated that hsa-miR-99b and hsa-miR-125a could be associated with the phenotypes manifested by p.F508del patients. Here we provide novel elements in the mechanism of hsa-miR-99b and hsa-miR-125a biogenesis, and for the role of CFTR and DeltaF508-CFTR on the expression of this miRNA cluster. These findings augment existing data implicating miRNAs as putative CF modifiers." -other hsa-mir-99b Cystic Fibrosis 25800681 "Ingenuity Pathway Analysis indicated that hsa-miR-99b and hsa-miR-125a could be associated with the phenotypes manifested by p.F508del patients. Here we provide novel elements in the mechanism of hsa-miR-99b and hsa-miR-125a biogenesis, and for the role of CFTR and DeltaF508-CFTR on the expression of this miRNA cluster. These findings augment existing data implicating miRNAs as putative CF modifiers." -other hsa-mir-548c Breast Neoplasms 25802200 "we showed that miR-548c-3p is implicated in doxorubicin-treated MCF-7 cell viability, suggesting a role for this miRNA in resistance." -other hsa-mir-130b Cholestasis 25802328 "These data support miR-130b as a potential negative regulator of drug metabolism by directly and/or indirectly affecting the expression of several ADME genes. This may be of relevance in pathophysiologic conditions such as cholestasis and inflammation, which are associated with increased miR-130b expression." -other hsa-let-7a "Squamous Cell Carcinoma, Lung" 25802847 "The novel candidate key drivers in this refined subnetwork, such as the methylation of ARHGDIB and HOXD3, microRNA let-7a and miR-31, and the CNV of AGAP2, were identified and analyzed." -other hsa-mir-20a "Carcinoma, Cervical" 25803820 MiR-20a promotes cervical cancer proliferation and metastasis in vitro and in vivo. -other hsa-mir-143 Bladder Neoplasms 25804644 "The cancer-related miR-143, miR-145 and miR-224 were investigated for the first time in the clinical setting of BlCa, and miR-143/145 cluster constitutes a novel marker helpful for providing an enhanced prediction of oncologic outcome for BlCa patients." -other hsa-mir-145 Bladder Neoplasms 25804644 "The cancer-related miR-143, miR-145 and miR-224 were investigated for the first time in the clinical setting of BlCa, and miR-143/145 cluster constitutes a novel marker helpful for providing an enhanced prediction of oncologic outcome for BlCa patients." -other hsa-mir-224 Bladder Neoplasms 25804644 "The cancer-related miR-143, miR-145 and miR-224 were investigated for the first time in the clinical setting of BlCa, and miR-143/145 cluster constitutes a novel marker helpful for providing an enhanced prediction of oncologic outcome for BlCa patients." -other hsa-mir-146a Inflammation 25805648 "the model of endotoxin tolerance is suitable for the antagonistic effects on the dysregulation of ABCA1/G1 induced by high dose of P.g LPS.Conversely, low-dose AGEs did not induce the model of P.g LPS-mediated tolerance." -other hsa-mir-1290 "Squamous Cell Carcinoma, Esophageal" 25805931 Our findings suggested that miR-1290 may play an oncogenic role in cellular processes of ESCC. -other hsa-mir-200c Neoplasms [unspecific] 25808651 "A Comprehensive Review on miR-200c, A Promising Cancer Biomarker with Therapeutic Potential." -other hsa-mir-29 Human Immunodeficiency Virus Infection 25808800 "The miRNA-29 family could influence the clinical progression of HIV-1 infection, the HIV-1 proviral load and the innate immune response against HIV-1." -other hsa-mir-9 "Adenocarcinoma, Cervical" 25809226 our results here present a tumor suppressor potential of miR-9 in cervical adenocarcinoma for the first time and suggest that miR-9 could repress tumorigenesis through inhibiting the activity of IL-6/Jak/STAT3 pathway.has-miR-146b-5p -other hsa-mir-210 Neoplasms [unspecific] 25809609 The role of hypoxia-induced miR-210 in cancer progression. -other hsa-mir-494 "Carcinoma, Nasopharyngeal" 25809707 Functional elucidation of miR-494 in the tumorigenesis of nasopharyngeal carcinoma. -other hsa-mir-15b Glioma 25811315 Decreased Expression of miR-15b in Human Gliomas is Associated with Poor Prognosis. -other hsa-mir-518a Colorectal Carcinoma 25812680 Downregulation of miR-518a-3p activates the NIK-dependent NF-¦ÊB pathway in colorectal cancer. -other hsa-mir-16 "Carcinoma, Renal Cell" 25815587 Upregulated microRNA-16 as an oncogene in renal cell carcinoma. -other hsa-mir-103-1 Bipolar Disorder 25817407 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. -other hsa-mir-103-1 Schizophrenia 25817407 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. -other hsa-mir-124 Bipolar Disorder 25817407 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. -other hsa-mir-124 Schizophrenia 25817407 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. -other hsa-mir-132 Bipolar Disorder 25817407 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. -other hsa-mir-132 Schizophrenia 25817407 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. -other hsa-mir-138 Bipolar Disorder 25817407 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. -other hsa-mir-138 Schizophrenia 25817407 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. -other hsa-mir-206 Bipolar Disorder 25817407 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. -other hsa-mir-206 Schizophrenia 25817407 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. -other hsa-mir-218-1 Bipolar Disorder 25817407 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. -other hsa-mir-218-1 Schizophrenia 25817407 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. -other hsa-mir-34a Bipolar Disorder 25817407 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. -other hsa-mir-34a Schizophrenia 25817407 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. -other hsa-mir-449a Bipolar Disorder 25817407 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. -other hsa-mir-449a Schizophrenia 25817407 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. -other hsa-mir-9-3 Bipolar Disorder 25817407 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. -other hsa-mir-9-3 Schizophrenia 25817407 Our approach of integrating PGC findings with eQTL results can be used to generate specific hypotheses regarding the role of miRNAs in SZ and BD. -other hsa-mir-340 Glioblastoma 25817794 "miR-340 inhibits glioblastoma cell proliferation by suppressing CDK6, cyclin-D1 and cyclin-D2." -other hsa-mir-124 Colorectal Carcinoma 25818238 MicroRNA-124 inhibits cancer cell growth through PTB1/PKM1/PKM2 feedback cascade in colorectal cancer. -other hsa-mir-155 "Lymphoma, Large-Cell, Anaplastic" 25820993 Oncogenic role of miR-155 in anaplastic large cell lymphoma lacking the t(2;5) translocation. -other hsa-mir-122 "Carcinoma, Hepatocellular" 25823567 Regulation of the oncogenic function of distal-less 4 by microRNA-122 in hepatocellular carcinoma. -other hsa-mir-93 Glioma 25823655 miR-93 promotes cell proliferation in gliomas through activation of PI3K/Akt signaling pathway. -other hsa-mir-1323 Lung Neoplasms 25823795 Knockdown of microRNA-1323 restores sensitivity to radiation by suppression of PRKDC activity in radiation-resistant lung cancer cells. -other hsa-mir-328 Breast Neoplasms 25824027 Arsenic trioxide inhibits breast cancer cell growth via microRNA-328/hERG pathway in MCF-7 cells. -other hsa-mir-223 Pleural Mesothelioma 25824152 Loss of miR-223 and JNK Signaling Contribute to Elevated Stathmin in Malignant Pleural Mesothelioma. -other hsa-mir-210 Pulmonary Hypertension 25825391 Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension. -other hsa-mir-193a Neoplasms [unspecific] 25826780 "Our findings have provided new insights into mechanisms of CIK cells production and tumor cytotoxic function, and shed light on their safety for clinical trial." -other hsa-mir-181c Breast Neoplasms 25828099 Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier. -other hsa-mir-208a Myocardial Infarction 25828373 Targeting MicroRNA-208a to Suppress Adverse Postmyocardial Infarction Remodelling Related to RNA Activation of Endoglin Gene Expression. -other hsa-mir-23a Heart Failure 25829494 Heat shock inhibition of CDK5 increases NOXA levels through miR-23a repression. -other hsa-mir-21 Lung Neoplasms 25831148 Abnormal Expression of miR-21 and miR-95 in Cancer Stem-Like Cells is Associated with Radioresistance of Lung Cancer. -other hsa-mir-95 Lung Neoplasms 25831148 Abnormal Expression of miR-21 and miR-95 in Cancer Stem-Like Cells is Associated with Radioresistance of Lung Cancer. -other hsa-mir-340 Glioblastoma 25831237 miR-340 suppresses glioblastoma multiforme. -other hsa-mir-200 "Carcinoma, Colon" 25832648 Loss of miR-200 family in 5-fluorouracil resistant colon cancer drives lymphendothelial invasiveness in vitro. -other hsa-mir-451 Glioblastoma 25833239 low levels of glucose affect metabolism and activate cell migration through the miR-451-AMPK control system -other hsa-mir-150 "Leukemia, Lymphocytic, Chronic, B-Cell" 25833959 "this study successfully characterized CLL exosomes, demonstrated the control of BCR signaling in the release of CLL exosomes, and uncovered a disease-relevant exosome microRNA profile." -other hsa-mir-155 "Leukemia, Lymphocytic, Chronic, B-Cell" 25833959 "this study successfully characterized CLL exosomes, demonstrated the control of BCR signaling in the release of CLL exosomes, and uncovered a disease-relevant exosome microRNA profile." -other hsa-mir-223 "Leukemia, Lymphocytic, Chronic, B-Cell" 25833959 "this study successfully characterized CLL exosomes, demonstrated the control of BCR signaling in the release of CLL exosomes, and uncovered a disease-relevant exosome microRNA profile." -other hsa-mir-29 "Leukemia, Lymphocytic, Chronic, B-Cell" 25833959 "this study successfully characterized CLL exosomes, demonstrated the control of BCR signaling in the release of CLL exosomes, and uncovered a disease-relevant exosome microRNA profile." -other hsa-mir-122 Hepatitis C Virus Infection 25836383 The binding of p68 onto HCV RNA can be specifically inhibited by miR-122 via a competitive binding process. -other hsa-mir-182 Glioblastoma 25838542 "miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma." -other hsa-mir-199a "Carcinoma, Ovarian" 25839163 The hypoxia-related microRNA miR-199a-3p displays tumor suppressor functions in ovarian carcinoma. -other hsa-mir-208 Heart Failure 25840809 miR-208 family is closely associated with the development of cardiac diseases -other hsa-mir-208 Vascular Hypertrophy 25840809 miR-208 family is closely associated with the development of cardiac diseases -other hsa-mir-203 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 25840888 Effect of microRNA-203 on tumor growth in human hypopharyngeal squamous cell carcinoma. -other hsa-mir-132 Pancreatic Neoplasms 25840985 Xenograft tumors treated with ormeloxifene in combination with gemcitabine restored the tumor-suppressor miR-132 and inhibited stromal cell infiltration into the tumor tissues. -other hsa-mir-889 "Squamous Cell Carcinoma, Esophageal" 25841337 miR-889 promotes proliferation of esophageal squamous cell carcinomas through DAB2IP. -other hsa-mir-942 "Squamous Cell Carcinoma, Esophageal" 25844602 miR-942 promotes cancer stem cell-like traits in esophageal squamous cell carcinoma through activation of Wnt/¦Â-catenin signalling pathway. -other hsa-mir-99a Chronic Hepatitis C 25844942 "IFI35, mir-99a and HCV genotype to predict sustained virological response to pegylated-interferon plus ribavirin in chronic hepatitis C." -other hsa-mir-154 Lung Neoplasms 25846246 miR-154 suppresses non-small cell lung cancer growth in vitro and in vivo. -other hsa-mir-210 Prostate Neoplasms 25846647 "Treatment with MIB led to an induction of miR-210 expression, a hypoxia-related miRNA" -other hsa-mir-221 Prostate Neoplasms 25846647 This observation indicates that this miRNA may have a more complex role in prostate cancer development than considered previously.Thus examining the effect of androgen receptor (AR) agonists and antagonists on miRNA expression can provide novel insights into the response of cells to androgen receptor (AR) ligands and subsequent downstream events. -other hsa-mir-335 "Carcinoma, Renal Cell, Clear-Cell" 25846734 miR-335 inhibits the proliferation and invasion of clear cell renal cell carcinoma cells through direct suppression of BCL-W. -other hsa-mir-9 "Carcinoma, Ovarian" 25846738 MicroRNA-9 promotes tumorigenesis and mediates sensitivity to cisplatin in primary epithelial ovarian cancer cells. -other hsa-mir-27b Congenital Heart Diseases 25847058 "The current study revealed for the first time that microRNAs may be important regulators in pulmonary arterial hypertension secondary to congenital heart disease, and demonstrated the correlation between microRNA-27b and pulmonary arterial hypertension with the implication of NOTCH1." -other hsa-mir-144 Osteosarcoma 25854173 "MicroRNA-144 inhibits the proliferation, apoptosis, invasion, and migration of osteosarcoma cell line F5M2." -other hsa-mir-125a Vascular Disease [unspecific] 25854878 These translational data emphasize the pathogenetic role of miR-125a in pulmonary vascular remodeling. -other hsa-mir-122 Hepatitis C Virus Infection 25855736 Regulation of Hepatitis C Virus Genome Replication by Xrn1 and MicroRNA-122 Binding to Individual Sites in the 5' Untranslated Region. -other hsa-mir-183 Neoplasms [unspecific] 25856466 "Let-7, mir-98 and mir-183 as biomarkers for cancer and schizophrenia [corrected]." -other hsa-mir-98 Neoplasms [unspecific] 25856466 "Let-7, mir-98 and mir-183 as biomarkers for cancer and schizophrenia [corrected]." -other hsa-mir-100 Cardiovascular Diseases [unspecific] 25857370 "In endothelial cells, activation of PPAR-¦Ä decreased VLDL receptor expression and VLDL uptake via the induction of miR-100. These results provided a novel mechanism for the vascular protective effect of PPAR-¦Ä agonists." -other hsa-mir-29a "Scleroderma, Systemic" 25857445 MicroRNA-29a induces apoptosis via increasing the Bax:Bcl-2 ratio in dermal fibroblasts of patients with systemic sclerosis. -other hsa-mir-25 "Carcinoma, Prostate" 25858144 miR-25 Modulates Invasiveness and Dissemination of Human Prostate Cancer Cells via Regulation of ¦Áv- and ¦Á6-Integrin Expression. -other hsa-mir-93 Viral Infectious Disease 25858415 Generation of a safe and effective live viral vaccine by virus self-attenuation using species-specific artificial microRNA. -other hsa-mir-29c "Leukemia, Lymphocytic, Chronic, B-Cell" 25860243 "Our data identify biological characteristics associated with subset #4 patients, providing further evidence for the putative role of BCR in shaping the features of the tumor cells in CLL." -other hsa-mir-497 "Leukemia, Lymphocytic, Chronic, B-Cell" 25860243 "Our data identify biological characteristics associated with subset #4 patients, providing further evidence for the putative role of BCR in shaping the features of the tumor cells in CLL." -other hsa-mir-1234 Gastric Neoplasms 25861021 These data provide a theoretical basis for the potential interaction between miRNA and the ¦Â-catenin signaling pathway in GC. -other hsa-mir-135b Gastric Neoplasms 25861021 These data provide a theoretical basis for the potential interaction between miRNA and the ¦Â-catenin signaling pathway in GC. -other hsa-mir-20a Gastric Neoplasms 25861021 These data provide a theoretical basis for the potential interaction between miRNA and the ¦Â-catenin signaling pathway in GC. -other hsa-mir-210 Gastric Neoplasms 25861021 These data provide a theoretical basis for the potential interaction between miRNA and the ¦Â-catenin signaling pathway in GC. -other hsa-mir-23b Gastric Neoplasms 25861021 These data provide a theoretical basis for the potential interaction between miRNA and the ¦Â-catenin signaling pathway in GC. -other hsa-mir-423 Gastric Neoplasms 25861021 These data provide a theoretical basis for the potential interaction between miRNA and the ¦Â-catenin signaling pathway in GC. -other hsa-mir-455 Gastric Neoplasms 25861021 These data provide a theoretical basis for the potential interaction between miRNA and the ¦Â-catenin signaling pathway in GC. -other hsa-mir-4739 Gastric Neoplasms 25861021 These data provide a theoretical basis for the potential interaction between miRNA and the ¦Â-catenin signaling pathway in GC. -other hsa-mir-494 "Carcinoma, Lung, Non-Small-Cell" 25861022 Expression and clinical evidence of miR-494 and PTEN in non-small cell lung cancer. -other hsa-mir-106b Pituitary Neoplasms 25862551 "Our results suggest microRNA involvement in malignant pituitary progression, whereby increased miR-20a, miR-106b and miR-17-5p promote metastasis by attenuating PTEN and TIMP2 in pituitary carcinoma." -other hsa-mir-17 Pituitary Neoplasms 25862551 "Our results suggest microRNA involvement in malignant pituitary progression, whereby increased miR-20a, miR-106b and miR-17-5p promote metastasis by attenuating PTEN and TIMP2 in pituitary carcinoma." -other hsa-mir-20a Pituitary Neoplasms 25862551 "Our results suggest microRNA involvement in malignant pituitary progression, whereby increased miR-20a, miR-106b and miR-17-5p promote metastasis by attenuating PTEN and TIMP2 in pituitary carcinoma." -other hsa-mir-29c Pancreatic Neoplasms 25863127 miR-29c suppresses pancreatic cancer liver metastasis in an orthotopic implantation model in nude mice and affects survival in pancreatic cancer patients. -other hsa-mir-222 Cardiovascular Diseases [unspecific] 25863248 These studies implicate miR-222 as necessary for exercise-induced cardiomyocyte growth and proliferation in the adult mammalian heart and show that it is sufficient to protect the heart against adverse remodeling. -other hsa-mir-148a Bladder Neoplasms 25865490 miR-148a dependent apoptosis of bladder cancer cells is mediated in part by the epigenetic modifier DNMT1. -other hsa-mir-150 "Lymphoma, Large B-Cell, Diffuse" 25866097 miR signature from DLBCL biopsies can discriminate between patients with favorable and poor prognoses. -other hsa-mir-155 "Lymphoma, Large B-Cell, Diffuse" 25866097 miR signature from DLBCL biopsies can discriminate between patients with favorable and poor prognoses. -other hsa-mir-18a "Lymphoma, Large B-Cell, Diffuse" 25866097 miR signature from DLBCL biopsies can discriminate between patients with favorable and poor prognoses. -other hsa-mir-221 "Lymphoma, Large B-Cell, Diffuse" 25866097 miR signature from DLBCL biopsies can discriminate between patients with favorable and poor prognoses. -other hsa-mir-222 "Lymphoma, Large B-Cell, Diffuse" 25866097 miR signature from DLBCL biopsies can discriminate between patients with favorable and poor prognoses. -other hsa-mir-342 "Lymphoma, Large B-Cell, Diffuse" 25866097 miR signature from DLBCL biopsies can discriminate between patients with favorable and poor prognoses. -other hsa-mir-621 Breast Neoplasms 25867061 MiRNA-621 sensitizes breast cancer to chemotherapy by suppressing FBXO11 and enhancing p53 activity. -other hsa-mir-149 "Stroke, Ischemic" 25867405 Effect of a pre-microRNA-149 (miR-149) genetic variation on the risk of ischemic stroke in a Chinese Han population. -other hsa-mir-103 Myocardial Infarction 25867756 This study provides more details on gene expression regulation and regulators involved in MI progression and recurrence. It also linked up and interpreted many previous results. -other hsa-mir-16 Myocardial Infarction 25867756 This study provides more details on gene expression regulation and regulators involved in MI progression and recurrence. It also linked up and interpreted many previous results. -other hsa-mir-26 Myocardial Infarction 25867756 This study provides more details on gene expression regulation and regulators involved in MI progression and recurrence. It also linked up and interpreted many previous results. -other hsa-mir-320 Myocardial Infarction 25867756 This study provides more details on gene expression regulation and regulators involved in MI progression and recurrence. It also linked up and interpreted many previous results. -other hsa-let-7b Melanoma 25868368 The concomitant inhibition of MMP-9 and MMP-13 affects prognosis and survival in skin melanoma. -other hsa-mir-21 Melanoma 25868368 The concomitant inhibition of MMP-9 and MMP-13 affects prognosis and survival in skin melanoma. -other hsa-mir-451 Osteosarcoma 25869073 Suppression of liver receptor homolog-1 by microRNA-451 represses the proliferation of osteosarcoma cells. -other hsa-let-7i Glioblastoma 25869098 MicroRNA profiling of Chinese primary glioblastoma reveals a temozolomide-chemoresistant subtype. -other hsa-mir-1238 Glioblastoma 25869098 MicroRNA profiling of Chinese primary glioblastoma reveals a temozolomide-chemoresistant subtype. -other hsa-mir-1280 Glioblastoma 25869098 MicroRNA profiling of Chinese primary glioblastoma reveals a temozolomide-chemoresistant subtype. -other hsa-mir-151 Glioblastoma 25869098 MicroRNA profiling of Chinese primary glioblastoma reveals a temozolomide-chemoresistant subtype. -other hsa-mir-423 Glioblastoma 25869098 MicroRNA profiling of Chinese primary glioblastoma reveals a temozolomide-chemoresistant subtype. -other hsa-mir-93 Glioblastoma 25869098 MicroRNA profiling of Chinese primary glioblastoma reveals a temozolomide-chemoresistant subtype. -other hsa-mir-938 Glioblastoma 25869098 MicroRNA profiling of Chinese primary glioblastoma reveals a temozolomide-chemoresistant subtype. -other hsa-mir-17 Lymphoma 25870038 "Functional interactions among members of the miR-17-92 cluster in lymphocyte development, differentiation and malignant transformation." -other hsa-mir-18 Lymphoma 25870038 "Functional interactions among members of the miR-17-92 cluster in lymphocyte development, differentiation and malignant transformation." -other hsa-mir-19a Lymphoma 25870038 "Functional interactions among members of the miR-17-92 cluster in lymphocyte development, differentiation and malignant transformation." -other hsa-mir-19b-1 Lymphoma 25870038 "Functional interactions among members of the miR-17-92 cluster in lymphocyte development, differentiation and malignant transformation." -other hsa-mir-20a Lymphoma 25870038 "Functional interactions among members of the miR-17-92 cluster in lymphocyte development, differentiation and malignant transformation." -other hsa-mir-92-1 Lymphoma 25870038 "Functional interactions among members of the miR-17-92 cluster in lymphocyte development, differentiation and malignant transformation." -other hsa-mir-101 Graves Disease 25871842 Our study highlights the possibility that miRNA-target gene network may be involved in the pathogenesis of GD and could provide new insights into understanding the pathophysiological mechanisms of GD. -other hsa-mir-96 Pulmonary Hypertension 25871906 "Increased 5-HT1BR expression may be a consequence of decreased miRNA-96 expression in female patient human pulmonary artery smooth muscle cell(PASMCs), and this may contribute to the development of pulmonary arterial hypertension (PAH)." -other hsa-mir-203 Pancreatic Neoplasms 25872941 This led to the identification of both its target gene miR-203 as a major drug sensitizer -other hsa-mir-155 Human Immunodeficiency Virus Infection 25873391 "we demonstrate that TRIM32, an E3 ubiquitin ligase, promotes reactivation from latency by directly modifying I¦ÊB¦Á, leading to a novel mechanism of NF-¦ÊB induction not involving I¦ÊB kinase activation." -other hsa-mir-326 Thrombosis 25875481 "The effect of miR-326 appeared to be limited to apoptosis,with no significant effect on platelet activation. These results provide new insight into the molecular mechanisms affecting differential platelet gene regulation, which may increase understanding of the role of platelet apoptosis in multiple diseases." -other hsa-mir-494 "Carcinoma, Cervical" 25877755 MiRNA-494 inhibits metastasis of cervical cancer through Pttg1. -other hsa-mir-23a "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 25879432 "miR-23a, an independent prognostic factor for laryngeal cancer,participates in the onset and progression of laryngeal cancer." -other hsa-mir-21 Breast Neoplasms 25880495 Formulation of Anti-miR-21 and 4-Hydroxytamoxifen Co-loaded Biodegradable Polymer Nanoparticles and Their Antiproliferative Effect on Breast Cancer Cells. -other hsa-mir-7 Schizophrenia 25882257 MicroRNA-7/Shank3 axis involved in schizophrenia pathogenesis. -other hsa-mir-21 Atherosclerosis 25882990 "In atherosclerosis, miR-21 is increased in the aorta and associated with vitamin D deficiency. Vitamin D deficiency may influence aberrant miR-21 expression in vasculature and bone contributing to the concurrent development of atherosclerosis and osteoporosis." -other hsa-mir-141 Bladder Neoplasms 25884322 "MiRNA-141 and miRNA-200b play important roles in the invasive ability and EMT phenotype of bladder cancer. Detection of miRNA-141 and miRNA-200b can help to identify patients undergoing cystectomy who are likely to have lymph node metastasis, and therefore those who may benefit from super-extended PLND." -other hsa-mir-200b Bladder Neoplasms 25884322 "MiRNA-141 and miRNA-200b play important roles in the invasive ability and EMT phenotype of bladder cancer. Detection of miRNA-141 and miRNA-200b can help to identify patients undergoing cystectomy who are likely to have lymph node metastasis, and therefore those who may benefit from super-extended PLND." -other hsa-mir-155 "Leukemia, Lymphocytic, Chronic, B-Cell" 25886051 Role of microRNA in chronic lymphocytic leukemia onset and progression. -other hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 25886051 Role of microRNA in chronic lymphocytic leukemia onset and progression. -other hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 25886051 Role of microRNA in chronic lymphocytic leukemia onset and progression. -other hsa-mir-17 "Leukemia, Lymphocytic, Chronic, B-Cell" 25886051 Role of microRNA in chronic lymphocytic leukemia onset and progression. -other hsa-mir-181b "Leukemia, Lymphocytic, Chronic, B-Cell" 25886051 Role of microRNA in chronic lymphocytic leukemia onset and progression. -other hsa-mir-29 "Leukemia, Lymphocytic, Chronic, B-Cell" 25886051 Role of microRNA in chronic lymphocytic leukemia onset and progression. -other hsa-mir-34 "Leukemia, Lymphocytic, Chronic, B-Cell" 25886051 Role of microRNA in chronic lymphocytic leukemia onset and progression. -other hsa-mir-92 "Leukemia, Lymphocytic, Chronic, B-Cell" 25886051 Role of microRNA in chronic lymphocytic leukemia onset and progression. -other hsa-mir-142 Crohn Disease 25886994 "A panel of miRNAs(miR-19a, miR-21, miR-31, miR-101, miR-146a, and miR-375) may be used as markers to identify and discriminate between CD and UC." -other hsa-mir-21 Crohn Disease 25886994 "A panel of miRNAs(miR-19a, miR-21, miR-31, miR-101, miR-146a, and miR-375) may be used as markers to identify and discriminate between CD and UC." -other hsa-mir-31 Crohn Disease 25886994 "A panel of miRNAs(miR-19a, miR-21, miR-31, miR-101, miR-146a, and miR-375) may be used as markers to identify and discriminate between CD and UC." -other hsa-mir-1307 Ovarian Neoplasms 25887170 Our results suggest that miRNA-1307 may play a role in the development of chemoresistance in ovarian cancer. -other hsa-mir-34a Cardiovascular Diseases [unspecific] 25887273 "Also, miR-125a-5p/-351, miR-200c/-429, miR-106b/-17, miR-363/-92b, miR-181b/-181d, miR-19a/-19b, let-7d/-7f, miR-18a/-18b, miR-128/-27b and miR-106a/-291a-3p pairs exhibited significant synergy and their association to aging and/or cardiovascular diseases is supported in many cases by a disease database and previous studies." -other hsa-mir-17 Neoplasms [unspecific] 25887381 "Our findings therefore identify the miR-17-92 cluster as a functionally determining family of miRNAs in CSCs, and highlight the putative potential of developing modulators of this cluster to overcome drug resistance in pancreatic CSCs." -other hsa-mir-18 Neoplasms [unspecific] 25887381 "Our findings therefore identify the miR-17-92 cluster as a functionally determining family of miRNAs in CSCs, and highlight the putative potential of developing modulators of this cluster to overcome drug resistance in pancreatic CSCs." -other hsa-mir-19a Neoplasms [unspecific] 25887381 "Our findings therefore identify the miR-17-92 cluster as a functionally determining family of miRNAs in CSCs, and highlight the putative potential of developing modulators of this cluster to overcome drug resistance in pancreatic CSCs." -other hsa-mir-19b-1 Neoplasms [unspecific] 25887381 "Our findings therefore identify the miR-17-92 cluster as a functionally determining family of miRNAs in CSCs, and highlight the putative potential of developing modulators of this cluster to overcome drug resistance in pancreatic CSCs." -other hsa-mir-20a Neoplasms [unspecific] 25887381 "Our findings therefore identify the miR-17-92 cluster as a functionally determining family of miRNAs in CSCs, and highlight the putative potential of developing modulators of this cluster to overcome drug resistance in pancreatic CSCs." -other hsa-mir-92-1 Neoplasms [unspecific] 25887381 "Our findings therefore identify the miR-17-92 cluster as a functionally determining family of miRNAs in CSCs, and highlight the putative potential of developing modulators of this cluster to overcome drug resistance in pancreatic CSCs." -other hsa-mir-125b "Carcinoma, Hepatocellular" 25889022 This finding provides the novel evidence for GLPS on inhibition of HCC through miR-125b inhibiting Tregs accumulation and function. -other hsa-mir-141 Neoplasms [unspecific] 25889350 "The DNA tweezers also show high selectivity toward the fuel strand and can be used to monitor miR-141 expression in cancer cells, which provides new opportunities for the application of the dynamic DNA devices in clinical diagnostics." -other hsa-mir-146a Japanese Encephalitis Virus Infection 25889446 Upregulation of miR-146a by JEV JaOArS982 strain leads to suppression of NF-¦ÊB activity and disruption of antiviral Jak-STAT signaling which helps the virus to evade the cellular immune response. This effect of JEV infection on miR-146a expression was found to be strain specific. -other hsa-mir-21 Muscular Dystrophy 25892183 Opposing roles of miR-21 and miR-29 in the progression of fibrosis in Duchenne muscular dystrophy. -other hsa-mir-29 Muscular Dystrophy 25892183 Opposing roles of miR-21 and miR-29 in the progression of fibrosis in Duchenne muscular dystrophy. -other hsa-mir-31 "Carcinoma, Cervical" 25894339 Our results suggested that miR-31 plays an oncogenetic role in the development and progression of cervical cancer. -other hsa-mir-129 Ovarian Neoplasms 25895125 A novel role for microRNA-129-5p in inhibiting ovarian cancer cell proliferation and survival via direct suppression of transcriptional co-activators YAP and TAZ. -other hsa-mir-34a Neoplasms [unspecific] 25896587 "miR-34a plays an important role in the anti-tumor effects of querctin in HCC, miR-34a may be a tiemolecule between the p53 and SIRT1 and is composed of a p53/miR-34a/SIRT1 signal feedback loop, which could enhance apoptosis signal and significantly promote cell apoptosis." -other hsa-mir-16 Gastric Neoplasms 25897338 Circulating MiR-16-5p and MiR-19b-3p as Two Novel Potential Biomarkers to Indicate Progression of Gastric Cancer. -other hsa-mir-19b Gastric Neoplasms 25897338 Circulating MiR-16-5p and MiR-19b-3p as Two Novel Potential Biomarkers to Indicate Progression of Gastric Cancer. -other hsa-mir-221 Gastrointestinal Stromal Tumor 25898773 miRNA-221 and miRNA-222 induce apoptosis via the KIT/AKT signalling pathway in gastrointestinal stromal tumours. -other hsa-mir-222 Gastrointestinal Stromal Tumor 25898773 miRNA-221 and miRNA-222 induce apoptosis via the KIT/AKT signalling pathway in gastrointestinal stromal tumours. -other hsa-mir-1 Neoplasms [unspecific] 25899823 "Our results suggest that the degradation status of ribosomal RNA is not always applicable to mRNA and microRNA. In fact, the stabilities of these RNA classes to exposure to ribonucleases are independent from each other, with microRNA being more stable than mRNA. The relative stability of microRNAs supports their potential and further development as biomarkers in a range of applications." -other hsa-mir-208 Neoplasms [unspecific] 25899823 "Our results suggest that the degradation status of ribosomal RNA is not always applicable to mRNA and microRNA. In fact, the stabilities of these RNA classes to exposure to ribonucleases are independent from each other, with microRNA being more stable than mRNA. The relative stability of microRNAs supports their potential and further development as biomarkers in a range of applications." -other hsa-mir-501 Neoplasms [unspecific] 25899823 "Our results suggest that the degradation status of ribosomal RNA is not always applicable to mRNA and microRNA. In fact, the stabilities of these RNA classes to exposure to ribonucleases are independent from each other, with microRNA being more stable than mRNA. The relative stability of microRNAs supports their potential and further development as biomarkers in a range of applications." -other hsa-mir-21 Lung Neoplasms 25901472 "The present study reports that DEPs increased miR-21 expression and then activated the PTEN/PI3K/AKT pathway in human bronchial epithelial (HBE) cells, which may serve as an important carcinogenic mechanism. However, the data revealed that short-term exposure to a high DEP concentration did not cause evident cell carcinogenesis in HBE cells." -other hsa-mir-21 Endomyocardial Fibrosis 25903305 Downregulation of miR-21 and p-ERK/ERK were observed in myocardial fibroblasts treated with UA in a dose-dependent manner compared with the control group both in vitro and in vivo. -other hsa-mir-21 Heart Failure 25903305 Downregulation of miR-21 and p-ERK/ERK were observed in myocardial fibroblasts treated with UA in a dose-dependent manner compared with the control group both in vitro and in vivo. -other hsa-mir-21 Vascular Hypertrophy 25903305 Downregulation of miR-21 and p-ERK/ERK were observed in myocardial fibroblasts treated with UA in a dose-dependent manner compared with the control group both in vitro and in vivo. -other hsa-let-7e Acute Coronary Syndrome 25903651 "These results demonstrate a significant reprogramming of the platelet miRNome during activation, with consequent significant changes in platelet proteome and provide for the first time substantial evidence that fine-tuning of resident mRNA translation by miRNAs is a key event in platelet pathophysiology." -other hsa-mir-107 Acute Coronary Syndrome 25903651 "These results demonstrate a significant reprogramming of the platelet miRNome during activation, with consequent significant changes in platelet proteome and provide for the first time substantial evidence that fine-tuning of resident mRNA translation by miRNAs is a key event in platelet pathophysiology." -other hsa-mir-15b Acute Coronary Syndrome 25903651 "These results demonstrate a significant reprogramming of the platelet miRNome during activation, with consequent significant changes in platelet proteome and provide for the first time substantial evidence that fine-tuning of resident mRNA translation by miRNAs is a key event in platelet pathophysiology." -other hsa-mir-486 Acute Coronary Syndrome 25903651 "These results demonstrate a significant reprogramming of the platelet miRNome during activation, with consequent significant changes in platelet proteome and provide for the first time substantial evidence that fine-tuning of resident mRNA translation by miRNAs is a key event in platelet pathophysiology." -other hsa-mir-92b Acute Coronary Syndrome 25903651 "These results demonstrate a significant reprogramming of the platelet miRNome during activation, with consequent significant changes in platelet proteome and provide for the first time substantial evidence that fine-tuning of resident mRNA translation by miRNAs is a key event in platelet pathophysiology." -other hsa-mir-103 Glioblastoma 25903655 "CSF exosomes were enriched for miRNAs relative to CSF microvesicles. In CSF, there is an average of one molecule of miRNA per 150-25,000 EVs. Most EVs derived from clinical biofluids are devoid of miRNA content." -other hsa-mir-125 Glioblastoma 25903655 "CSF exosomes were enriched for miRNAs relative to CSF microvesicles. In CSF, there is an average of one molecule of miRNA per 150-25,000 EVs. Most EVs derived from clinical biofluids are devoid of miRNA content." -other hsa-mir-21 Glioblastoma 25903655 "CSF exosomes were enriched for miRNAs relative to CSF microvesicles. In CSF, there is an average of one molecule of miRNA per 150-25,000 EVs. Most EVs derived from clinical biofluids are devoid of miRNA content." -other hsa-mir-24 Glioblastoma 25903655 "CSF exosomes were enriched for miRNAs relative to CSF microvesicles. In CSF, there is an average of one molecule of miRNA per 150-25,000 EVs. Most EVs derived from clinical biofluids are devoid of miRNA content." -other hsa-mir-145 "Adenocarcinoma, Gastric" 25904219 "Downregulation of the Genes Involved in Reprogramming (SOX2, c-MYC, miR-302,miR-145, and P21) in Gastric Adenocarcinoma." -other hsa-mir-302 "Adenocarcinoma, Gastric" 25904219 "Downregulation of the Genes Involved in Reprogramming (SOX2, c-MYC, miR-302,miR-145, and P21) in Gastric Adenocarcinoma." -other hsa-mir-146a "Lymphoma, B-Cell" 25906746 Together our findings illuminate a bona fide role for miR-146a in the modulation of B-cell oncogenesis and reveal the importance of understanding microRNA function in a cell- and disease-specific context. -other hsa-mir-150 Breast Neoplasms 25907662 "These results all indicated that when analyzing miRNAs in surgical pathology specimens of breast cancer as a biomarker, they should be examined as a cluster through miRNA profiling, rather than relying on the analysis of a single miRNA." -other hsa-mir-15b Breast Neoplasms 25907662 "These results all indicated that when analyzing miRNAs in surgical pathology specimens of breast cancer as a biomarker, they should be examined as a cluster through miRNA profiling, rather than relying on the analysis of a single miRNA." -other hsa-mir-191 Breast Neoplasms 25907662 "These results all indicated that when analyzing miRNAs in surgical pathology specimens of breast cancer as a biomarker, they should be examined as a cluster through miRNA profiling, rather than relying on the analysis of a single miRNA." -other hsa-mir-200c Breast Neoplasms 25907662 "These results all indicated that when analyzing miRNAs in surgical pathology specimens of breast cancer as a biomarker, they should be examined as a cluster through miRNA profiling, rather than relying on the analysis of a single miRNA." -other hsa-mir-21 Breast Neoplasms 25907662 "These results all indicated that when analyzing miRNAs in surgical pathology specimens of breast cancer as a biomarker, they should be examined as a cluster through miRNA profiling, rather than relying on the analysis of a single miRNA." -other hsa-mir-25 Breast Neoplasms 25907662 "These results all indicated that when analyzing miRNAs in surgical pathology specimens of breast cancer as a biomarker, they should be examined as a cluster through miRNA profiling, rather than relying on the analysis of a single miRNA." -other hsa-mir-96 Breast Neoplasms 25907662 "These results all indicated that when analyzing miRNAs in surgical pathology specimens of breast cancer as a biomarker, they should be examined as a cluster through miRNA profiling, rather than relying on the analysis of a single miRNA." -other hsa-mir-34a Lung Neoplasms 25909221 miR-497 and miR-34a retard lung cancer growth by co-inhibiting cyclin E1 (CCNE1). -other hsa-mir-497 Lung Neoplasms 25909221 miR-497 and miR-34a retard lung cancer growth by co-inhibiting cyclin E1 (CCNE1). -other hsa-let-7 Lung Neoplasms 25910758 MicroRNA as tools and therapeutics in lung cancer. -other hsa-mir-122 Lung Neoplasms 25910758 MicroRNA as tools and therapeutics in lung cancer. -other hsa-mir-126 Lung Neoplasms 25910758 MicroRNA as tools and therapeutics in lung cancer. -other hsa-mir-141 Lung Neoplasms 25910758 MicroRNA as tools and therapeutics in lung cancer. -other hsa-mir-182 Lung Neoplasms 25910758 MicroRNA as tools and therapeutics in lung cancer. -other hsa-mir-200 Lung Neoplasms 25910758 MicroRNA as tools and therapeutics in lung cancer. -other hsa-mir-205 Lung Neoplasms 25910758 MicroRNA as tools and therapeutics in lung cancer. -other hsa-mir-21 Lung Neoplasms 25910758 MicroRNA as tools and therapeutics in lung cancer. -other hsa-mir-221 Lung Neoplasms 25910758 MicroRNA as tools and therapeutics in lung cancer. -other hsa-mir-222 Lung Neoplasms 25910758 MicroRNA as tools and therapeutics in lung cancer. -other hsa-mir-29 Lung Neoplasms 25910758 MicroRNA as tools and therapeutics in lung cancer. -other hsa-mir-34 Lung Neoplasms 25910758 MicroRNA as tools and therapeutics in lung cancer. -other hsa-mir-522 Lung Neoplasms 25910758 MicroRNA as tools and therapeutics in lung cancer. -other hsa-mir-592 Lung Neoplasms 25910758 MicroRNA as tools and therapeutics in lung cancer. -other hsa-mir-7 Lung Neoplasms 25910758 MicroRNA as tools and therapeutics in lung cancer. -other hsa-mir-16 Lung Neoplasms 25912305 Lung tumorigenesis induced by human vascular endothelial growth factor (hVEGF)-A165 overexpression in transgenic mice and amelioration of tumor formation by miR-16. -other hsa-let-7e Systemic Lupus Erythematosus 25912736 "These data suggest that 17¦Â-estradiol amplifies the activation of IFN-¦Á signaling in B cells via IKK¦Å by down-regulating the expression of let-7e-5p, miR-98-5p and miR-145a-5p. Our findings may provide a new perspective for understanding the mechanism underlying the gender difference in the prevalence of SLE." -other hsa-mir-145a Systemic Lupus Erythematosus 25912736 "These data suggest that 17¦Â-estradiol amplifies the activation of IFN-¦Á signaling in B cells via IKK¦Å by down-regulating the expression of let-7e-5p, miR-98-5p and miR-145a-5p. Our findings may provide a new perspective for understanding the mechanism underlying the gender difference in the prevalence of SLE." -other hsa-mir-98 Systemic Lupus Erythematosus 25912736 "These data suggest that 17¦Â-estradiol amplifies the activation of IFN-¦Á signaling in B cells via IKK¦Å by down-regulating the expression of let-7e-5p, miR-98-5p and miR-145a-5p. Our findings may provide a new perspective for understanding the mechanism underlying the gender difference in the prevalence of SLE." -other hsa-mir-125b Leukemia 25915540 The Phosphoinositide 3-Kinase p110¦Á Isoform Regulates Leukemia Inhibitory Factor Receptor Expression via c-Myc and miR-125b to Promote Cell Proliferation in Medulloblastoma. -other hsa-mir-149 Neoplasms [unspecific] 25916550 Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment. -other hsa-mir-155 Ischemia-Reperfusion Injury 25916938 MicroRNA-155 aggravates ischemia-reperfusion injury by modulation of inflammatory cell recruitment and the respiratory oxidative burst. -other hsa-mir-101 Thyroid Adenomas 25916957 "These results support a role for miRNA in the regulation of extracellular matrix proteins and tissue remodeling occurring during tumor development, and in the important negative feedback of the cAMP pathway, which limits the consequences of its constitutive activation in these tumors." -other hsa-mir-144 Thyroid Adenomas 25916957 "These results support a role for miRNA in the regulation of extracellular matrix proteins and tissue remodeling occurring during tumor development, and in the important negative feedback of the cAMP pathway, which limits the consequences of its constitutive activation in these tumors." -other hsa-mir-155 Neoplasms [unspecific] 25918453 "Our data suggest that single miR-155 profiling has a potential to be used as a screening test for various carcinomas, and parallel testing of miR-155 confers an improved specificity compared to single miR-155 analysis." -other hsa-mir-224 Colorectal Carcinoma 25919696 "We describe a novel mechanism of KRAS regulation, and highlight the clinical utility of colorectal cancer-specific miRNAs as disease progression or clinical response biomarkers." -other hsa-mir-141 "Carcinoma, Prostate" 25921227 The work demonstrated here thus offers new opportunities for the construction of functional DNA nanostructures and for the application of these DNA nanostructures as an effective signal amplification means in the sensitive detection of nucleic acid biomarkers. -other hsa-mir-302a Prostate Neoplasms 25922934 MicroRNA-302a Suppresses Tumor Cell Proliferation by Inhibiting AKT in Prostate Cancer. -other hsa-mir-150 Colorectal Carcinoma 25924769 "We identified two circulating miRNAs capable of distinguishing patient groups with different diseases of the colon from each other, and patients with advanced cancer from benign disease groups." -other hsa-mir-34a Colorectal Carcinoma 25924769 "We identified two circulating miRNAs capable of distinguishing patient groups with different diseases of the colon from each other, and patients with advanced cancer from benign disease groups." -other hsa-let-7 Multiple Myeloma 25925570 "Our study establishes that the ribonuclease DIS3, targeting LIN28B, sustains the maturation of let-7 miRNAs and suggests the increased translation of critical oncogenes as one of the biological outcomes of DIS3 inactivation." -other hsa-mir-497 Colorectal Carcinoma 25926384 MiR-497 promotes metastasis of colorectal cancer cells through Nrdp1 inhibition. -other hsa-mir-148a Breast Neoplasms 25928008 Estradiol induces HOTAIR levels via GPER-mediated miR-148a inhibition in breast cancer. -other hsa-mir-155 Systemic Lupus Erythematosus 25929465 "These findings provide new insight into the mechanism underlying decreased CD1d expression on B cells in SLE, suggesting that inhibition of inflammation may increase CD1d expression in B cells to ameliorate SLE via modulating iNKT cells." -other hsa-mir-497 Colorectal Carcinoma 25929865 miRNA-497 Enhances the Sensitivity of Colorectal Cancer Cells to Neoadjuvant Chemotherapeutic Drug. -other hsa-mir-429 "Carcinoma, Hepatocellular" 25931210 our results here defined miR-429 as a key inducer for HCC pathogenesis and metastasis with potential utility for tumor intervention. -other hsa-mir-199a Osteosarcoma 25931818 Polymeric nanoparticle-based delivery of microRNA-199a-3p inhibits proliferation and growth of osteosarcoma cells. -other hsa-mir-106b Ovary Mixed Epithelial Carcinoma 25933027 Inhibition of Ovarian Epithelial Carcinoma Tumorigenesis and Progression by microRNA 106b Mediated through the RhoC Pathway. -other hsa-mir-10a Breast Neoplasms 25934412 "The data presented supports a potential tumour suppressor role for miR-10a in breast cancer, and highlights retinoic acid as a positive regulator of the microRNA." -other hsa-let-7c Cerebral Ischemia 25934573 MicroRNA let-7c-5p protects against cerebral ischemia injury via mechanisms involving the inhibition of microglia activation. -other hsa-mir-19 Colorectal Carcinoma 25934693 miR-19-Mediated Inhibition of Transglutaminase-2 Leads to Enhanced Invasion and Metastasis in Colorectal Cancer. -other hsa-mir-99a Prostate Neoplasms 25937401 A combination of low Ku80 expression and highly-induced miR-99a expression could be a promising marker for predicting rectal bleeding after radiotherapy. -other hsa-mir-135b "Squamous Cell Carcinoma, Skin or Unspecific" 25938461 MicroRNA-135b Regulates Leucine Zipper Tumor Suppressor 1 in Cutaneous Squamous Cell Carcinoma. -other hsa-mir-141 Multiple Sclerosis 25938517 "According to our results, miR-141 and miR-200a may be key miRNAs in progression of symptoms of MS through inducing differentiation of Th17 cells and inhibiting differentiation to Treg cells. Our data suggest that these miRNAs may probably inhibit negative regulators of Th17 cell differentiation, thus promoting its differentiation." -other hsa-mir-200a Multiple Sclerosis 25938517 "According to our results, miR-141 and miR-200a may be key miRNAs in progression of symptoms of MS through inducing differentiation of Th17 cells and inhibiting differentiation to Treg cells. Our data suggest that these miRNAs may probably inhibit negative regulators of Th17 cell differentiation, thus promoting its differentiation." -other hsa-mir-203 Alopecia 25939713 RBM28 contributes to HF growth regulation through modulation of miR-203 and p63 activity. -other hsa-mir-34a Neoplasms [unspecific] 25939820 Multivalent aptamer-RNA based fluorescent probes for carrier-free detection of cellular microRNA-34a in mucin1-expressing cancer cells. -other hsa-mir-301a Prostate Neoplasms 25940439 Infiltrated pre-adipocytes increase prostate cancer metastasis via modulation of the miR-301a/androgen receptor (AR)/TGF-¦Â1/Smad/MMP9 signals. -other hsa-mir-940 "Carcinoma, Hepatocellular" 25940592 MiR-940 inhibits hepatocellular carcinoma growth and correlates with prognosis of hepatocellular carcinoma patients. -other hsa-mir-218 Neoplasms [unspecific] 25940608 "A feedback loop between c-Src and miR-218 was revealed where c-Src inhibits transcription of SLIT2, which intronically hosts miR-218. These results show a novel regulatory pathway for RPTP¦Á-c-Src signalling." -other hsa-mir-9 Colorectal Carcinoma 25940709 Regulation of UHRF1 by microRNA-9 modulates colorectal cancer cell proliferation and apoptosis. -other hsa-mir-371 Neoplasms [unspecific] 25941115 MiR-371-373 cluster acts as a tumor-suppressor-miR and promotes cell cycle arrest in unrestricted somatic stem cells. -other hsa-mir-373 Neoplasms [unspecific] 25941115 MiR-371-373 cluster acts as a tumor-suppressor-miR and promotes cell cycle arrest in unrestricted somatic stem cells. -other hsa-mir-409 Kaposi Sarcoma 25942495 our data provide a more detailed understanding of KSHV latency and guide further studies of the biological significance of these changes. -other hsa-mir-708 Kaposi Sarcoma 25942495 our data provide a more detailed understanding of KSHV latency and guide further studies of the biological significance of these changes. -other hsa-mir-21 Neoplasms [unspecific] 25943710 We believe that this proposed sensitive and specific assay has great potential as a quantification method for miRNA detection in biomedical research and clinical diagnosis. -other hsa-mir-223 Diabetes Mellitus 25944670 "Thus, calpain inhibition may be one means of normalizing platelet miRNA processing as well as platelet function in diabetes mellitus." -other hsa-mir-15a Neoplasms [unspecific] 25945419 these data demonstrate that miR-15a/16 induced autophagy contribute partly to their inhibition of cell proliferation and enhanced chemotherapeutic efficacy of camptothecin(CPT). -other hsa-mir-16 Neoplasms [unspecific] 25945419 these data demonstrate that miR-15a/16 induced autophagy contribute partly to their inhibition of cell proliferation and enhanced chemotherapeutic efficacy of camptothecin(CPT). -other hsa-let-7b Neoplasms [unspecific] 25946136 Let-7 may represent a new class of chemosensitizer for the treatment of KRAS mutant tumors. -other hsa-mir-148a Pancreatic Neoplasms 25950085 The Interplay Between miR-148a and DNMT1 Might be Exploited for Pancreatic Cancer Therapy. -other hsa-mir-106a Glioma 25950430 The Effects and Molecular Mechanisms of MiR-106a in Multidrug Resistance Reversal in Human Glioma U87/DDP and U251/G Cell Lines. -other hsa-mir-4728 Neoplasms [unspecific] 25950472 ErbB2-intronic microRNA-4728: a novel tumor suppressor and antagonist of oncogenic MAPK signaling. -other hsa-mir-638 Lung Neoplasms 25952770 miR-638 is a new biomarker for outcome prediction of non-small cell lung cancer patients receiving chemotherapy. -other hsa-mir-137 "Carcinoma, Ovarian" 25955305 MicroRNA-137 suppresses tumor growth in epithelial ovarian cancer in vitro and in vivo. -other hsa-mir-206 Thyroid Neoplasms 25955685 miR-206 inhibits metastasis-relevant traits by degrading MRTF-A in anaplastic thyroid cancer. -other hsa-mir-221 Pancreatic Neoplasms 25955843 Metformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells. -other hsa-mir-650 Prostate Neoplasms 25956032 Oncogenic Activity of miR-650 in Prostate Cancer Is Mediated by Suppression of CSR1 Expression. -other hsa-mir-132 Brain Disease [unspecific] 25957996 "our findings demonstrate the novel role of TLR4-related microRNAs, especially miR-132, in the regulation of MRP8-induced astrocyte activation and highlight the importance of miR-132 in the modulation of innate immune response induced by endogenous ligands in neurological diseases." -other hsa-mir-146a Brain Disease [unspecific] 25957996 "our findings demonstrate the novel role of TLR4-related microRNAs, especially miR-132, in the regulation of MRP8-induced astrocyte activation and highlight the importance of miR-132 in the modulation of innate immune response induced by endogenous ligands in neurological diseases." -other hsa-mir-155 Brain Disease [unspecific] 25957996 "our findings demonstrate the novel role of TLR4-related microRNAs, especially miR-132, in the regulation of MRP8-induced astrocyte activation and highlight the importance of miR-132 in the modulation of innate immune response induced by endogenous ligands in neurological diseases." -other hsa-mir-126 Cardiovascular Diseases [unspecific] 25958013 "This review describes our current understanding of extracellular vesicle miRNA transfer, demonstrating the roles of miR-126, miR-146a, miR-143, and other miRNAs being shuttled from endothelial cells, stem cells, fibroblasts and others into myocytes, endothelial cells, and smooth muscle cells to activate cellular changes and modulate disease phenotypes." -other hsa-mir-143 Cardiovascular Diseases [unspecific] 25958013 "This review describes our current understanding of extracellular vesicle miRNA transfer, demonstrating the roles of miR-126, miR-146a, miR-143, and other miRNAs being shuttled from endothelial cells, stem cells, fibroblasts and others into myocytes, endothelial cells, and smooth muscle cells to activate cellular changes and modulate disease phenotypes." -other hsa-mir-146a Cardiovascular Diseases [unspecific] 25958013 "This review describes our current understanding of extracellular vesicle miRNA transfer, demonstrating the roles of miR-126, miR-146a, miR-143, and other miRNAs being shuttled from endothelial cells, stem cells, fibroblasts and others into myocytes, endothelial cells, and smooth muscle cells to activate cellular changes and modulate disease phenotypes." -other hsa-mir-194 "Squamous Cell Carcinoma, Oral" 25960215 miR-194 regulated AGK and inhibited cell proliferation of oral squamous cell carcinoma by reducing PI3K-Akt-FoxO3a signaling. -other hsa-mir-143 Breast Neoplasms 25961039 "In our integrated genomics analysis and experimental validation, a new frame to predict candidate biomarkers of breast cancer subtype is provided and offers assistance in order to understand the potential disease etiology of the breast cancer subtypes." -other hsa-mir-145 Breast Neoplasms 25961039 "In our integrated genomics analysis and experimental validation, a new frame to predict candidate biomarkers of breast cancer subtype is provided and offers assistance in order to understand the potential disease etiology of the breast cancer subtypes." -other hsa-mir-744 "Carcinoma, Nasopharyngeal" 25961434 MiR-744 functions as a proto-oncogene in nasopharyngeal carcinoma progression and metastasis via transcriptional control of ARHGAP5. -other hsa-mir-21 Atherosclerosis 25961718 resveratrol significantly reduced miR-21 expression -other hsa-mir-144 Uveal Melanoma 25961751 MiR-144 Inhibits Uveal Melanoma Cell Proliferation and Invasion by Regulating c-Met Expression. -other hsa-mir-30a "Carcinoma, Ovarian, Serous" 25962395 Urinary microRNA-30a-5p is a potential biomarker for ovarian serous adenocarcinoma. -other hsa-mir-214 "Squamous Cell Carcinoma, Tongue" 25962755 Cantharidin inhibits cell proliferation and promotes apoptosis in tongue squamous cell carcinoma through suppression of miR-214 and regulation of p53 and Bcl-2/Bax. -other hsa-mir-18a "Carcinoma, Cervical" 25963391 MicroRNA-18a enhances the radiosensitivity of cervical cancer cells by promoting radiation-induced apoptosis. -other hsa-mir-183 Liver Diseases [unspecific] 25963660 These results indicate that the modulation of miRNA processing by COX-2 is a key event in insulin signaling in liver and has potential clinical implications for the management of various hepatic dysfunctions. -other hsa-mir-122 Hepatitis C Virus Infection 25963774 The mechanism of HCV dyslipidemia is complex and could partly relate to the effect of miR-122 on lipid metabolism which requires further evaluation in a larger study. -other hsa-mir-125a Autoimmune Diseases [unspecific] 25963922 "Using a chemically synthesized miR-125a analogue,we show potential to re-programme the immune homeostasis in EAE models. These findings point to miR-125a as a critical factor that controls autoimmune diseases by stabilizing Treg-mediated immune homeostasis." -other hsa-mir-21 "Leukemia, Myeloid, Chronic" 25964959 "we demonstrate that in two CML cell lines exhibiting different biological characteristics, LQB-118 modulates NF¦ÊB subcellular localization, apparently independently of the AKT and MAPK pathways, partially inhibits proteasome activity, and alters the expression of microRNAs -9 and -21." -other hsa-mir-9 "Leukemia, Myeloid, Chronic" 25964959 "we demonstrate that in two CML cell lines exhibiting different biological characteristics, LQB-118 modulates NF¦ÊB subcellular localization, apparently independently of the AKT and MAPK pathways, partially inhibits proteasome activity, and alters the expression of microRNAs -9 and -21." -other hsa-mir-424 "Squamous Cell Carcinoma, Tongue" 25965165 "Our patient data show that microRNA-424 alterations are a marker of field cancerisation specific for tongue tumourigenesis, which also could have a role in development of tongue squamous cell carcinoma." -other hsa-mir-155 Bladder Neoplasms 25965824 MicroRNA-155 promotes bladder cancer growth by repressing the tumor suppressor DMTF1. -other hsa-let-7a Pregnancy Complications [unspecific] 25965838 "For samples measured preconception, ROC curve analysis demonstrated AUC 0.81 for adverse pregnancy outcome. Maternal PBMC microRNA can identify high-risk patients likely to benefit from immunotherapy with improved sensitivity and specificity compared with standard immune assays." -other hsa-mir-132 Pregnancy Complications [unspecific] 25965838 "For samples measured preconception, ROC curve analysis demonstrated AUC 0.81 for adverse pregnancy outcome. Maternal PBMC microRNA can identify high-risk patients likely to benefit from immunotherapy with improved sensitivity and specificity compared with standard immune assays." -other hsa-mir-146a Pregnancy Complications [unspecific] 25965838 "For samples measured preconception, ROC curve analysis demonstrated AUC 0.81 for adverse pregnancy outcome. Maternal PBMC microRNA can identify high-risk patients likely to benefit from immunotherapy with improved sensitivity and specificity compared with standard immune assays." -other hsa-mir-155 Pregnancy Complications [unspecific] 25965838 "For samples measured preconception, ROC curve analysis demonstrated AUC 0.81 for adverse pregnancy outcome. Maternal PBMC microRNA can identify high-risk patients likely to benefit from immunotherapy with improved sensitivity and specificity compared with standard immune assays." -other hsa-mir-16 Pregnancy Complications [unspecific] 25965838 "For samples measured preconception, ROC curve analysis demonstrated AUC 0.81 for adverse pregnancy outcome. Maternal PBMC microRNA can identify high-risk patients likely to benefit from immunotherapy with improved sensitivity and specificity compared with standard immune assays." -other hsa-mir-122 "Carcinoma, Hepatocellular" 25965999 "G¦Á12 overexpressed in hepatocellular carcinoma reduces microRNA-122 expression via HNF4¦Á inactivation, which causes c-Met induction." -other hsa-mir-200c "Carcinoma, Breast" 25967125 "our data suggests that expression of miR-200c-141 and ?Np63 in D492M can reverse EMT resulting in luminal- and myoepithelial differentiation, respectively,demonstrating the importance of these molecules in epithelial integrity in the human breast." -other hsa-mir-145 Prostate Neoplasms 25969144 miR-145 suppress the androgen receptor in prostate cancer cells and correlates to prostate cancer prognosis. -other hsa-mir-21 "Carcinoma, Hepatocellular" 25969534 Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells. -other hsa-mir-34a Oral Neoplasms 25973020 MiR-34a inhibits oral cancer progression partially by repression of interleukin-6-receptor. -other hsa-mir-101 Pheochromocytoma 25973039 Role of miR-101 in pheochromocytoma patients with SDHD mutation. -other hsa-mir-365 "Carcinoma, Hepatocellular" 25973057 Prognostic significance and anti-proliferation effect of microRNA-365 in hepatocellular carcinoma. -other hsa-mir-27a "Carcinoma, Renal Cell" 25973137 miR-27a promotes cell proliferation and metastasis in renal cell carcinoma. -other hsa-mir-122 Hepatitis [unspecific] 25973575 "These results demonstrate that first, exosomes mediate communication between hepatocytes and monocytes/macrophages and second, hepatocyte-derived miRNA-122 can reprogram monocytes inducing sensitization to LPS." -other hsa-mir-141 "Carcinoma, Renal Cell" 25974855 "We also constructed a five-miRNAs-based classifier as a reliable prognostic and predictive tool for CSS in patients with RCC, especially in clear cell RCC (ccRCC) (HR: 5.46, 95% CI: 1.51-19.66). This method might facilitate patient counselling and individualise management of RCC." -other hsa-mir-200c "Carcinoma, Renal Cell" 25974855 "We also constructed a five-miRNAs-based classifier as a reliable prognostic and predictive tool for CSS in patients with RCC, especially in clear cell RCC (ccRCC) (HR: 5.46, 95% CI: 1.51-19.66). This method might facilitate patient counselling and individualise management of RCC." -other hsa-mir-21 "Carcinoma, Renal Cell" 25974855 "We also constructed a five-miRNAs-based classifier as a reliable prognostic and predictive tool for CSS in patients with RCC, especially in clear cell RCC (ccRCC) (HR: 5.46, 95% CI: 1.51-19.66). This method might facilitate patient counselling and individualise management of RCC." -other hsa-mir-210 "Carcinoma, Renal Cell" 25974855 "We also constructed a five-miRNAs-based classifier as a reliable prognostic and predictive tool for CSS in patients with RCC, especially in clear cell RCC (ccRCC) (HR: 5.46, 95% CI: 1.51-19.66). This method might facilitate patient counselling and individualise management of RCC." -other hsa-mir-429 "Carcinoma, Renal Cell" 25974855 "We also constructed a five-miRNAs-based classifier as a reliable prognostic and predictive tool for CSS in patients with RCC, especially in clear cell RCC (ccRCC) (HR: 5.46, 95% CI: 1.51-19.66). This method might facilitate patient counselling and individualise management of RCC." -other hsa-mir-214 Bladder Neoplasms 25975233 "Urinary cell-free miR-214 is a hopeful biomarker for tumor stratification, early diagnosis and prognostic assessment of bladder cancer." -other hsa-mir-21 Cardiovascular Diseases [unspecific] 25975660 miR-21 and cardiac fibrosis: another brick in the wall -other hsa-mir-125a Myelodysplastic Syndromes 25976472 "In fact, regulatory factors have also been considered as miR-143/miR-145, miR-146a, miR-125a and MiR-21." -other hsa-mir-1307 Colorectal Carcinoma 25977444 The polymorphic terminal-loop of pre-miR-1307 binding with MBNL1 contributes to colorectal carcinogenesis via interference with Dicer1 recruitment. -other hsa-mir-17 Inflammation 25979460 Our finding that certain miRNAs may de-repress critical acute phase proteins within acute timeframes has important biological and clinical implications. -other hsa-mir-18 Inflammation 25979460 Our finding that certain miRNAs may de-repress critical acute phase proteins within acute timeframes has important biological and clinical implications. -other hsa-mir-19a Inflammation 25979460 Our finding that certain miRNAs may de-repress critical acute phase proteins within acute timeframes has important biological and clinical implications. -other hsa-mir-19b Inflammation 25979460 Our finding that certain miRNAs may de-repress critical acute phase proteins within acute timeframes has important biological and clinical implications. -other hsa-mir-19b-1 Inflammation 25979460 Our finding that certain miRNAs may de-repress critical acute phase proteins within acute timeframes has important biological and clinical implications. -other hsa-mir-20a Inflammation 25979460 Our finding that certain miRNAs may de-repress critical acute phase proteins within acute timeframes has important biological and clinical implications. -other hsa-mir-449c Inflammation 25979460 Our finding that certain miRNAs may de-repress critical acute phase proteins within acute timeframes has important biological and clinical implications. -other hsa-mir-455 Inflammation 25979460 Our finding that certain miRNAs may de-repress critical acute phase proteins within acute timeframes has important biological and clinical implications. -other hsa-mir-92-1 Inflammation 25979460 Our finding that certain miRNAs may de-repress critical acute phase proteins within acute timeframes has important biological and clinical implications. -other hsa-mir-21 Neoplasms [unspecific] 25979949 Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR-21-mediated tumor suppressor Pdcd4 repression. -other hsa-mir-373 Prostate Neoplasms 25980442 TR4 nuclear receptor increases prostate cancer invasion via decreasing the miR-373-3p expression to alter TGF¦ÂR2/p-Smad3 signals. -other hsa-mir-659 Neuroblastoma 25980492 Deregulation of focal adhesion pathway mediated by miR-659-3p is implicated in bone marrow infiltration of stage M neuroblastoma patients. -other hsa-mir-140 Colorectal Carcinoma 25980495 Inhibition of colorectal cancer stem cell survival and invasive potential by hsa-miR-140-5p mediated suppression of Smad2 and autophagy. -other hsa-mir-21 Atherosclerosis 25981603 miR-21 is involved in ischemic stroke pathology through atherosclerosis and provides neuroprotection by its anti-apoptotic features. -other hsa-mir-210 Atherosclerosis 25981603 miR-497 induces neuronal death and miR-210 is upregulated in hypoxic cells. -other hsa-mir-34b Hypoxia 25982511 "Sevoflurane preconditioning-inhibited apoptosis and preconditioning-enhanced cell viability of PC12 cells were significantly attenuated by transfection of miR-101a mimetic or miR-34b inhibitors, but were significantly enhanced by transfection of miR-34b mimetic." -other hsa-mir-183 Lung Neoplasms 25983004 MiR-183 promotes growth of non-small cell lung cancer cells through FoxO1 inhibition. -other hsa-mir-132 Glioma 25983322 TGF-¦Â induced miR-132 enhances the activation of TGF-¦Â signaling through inhibiting SMAD7 expression in glioma cells. -other hsa-mir-215 Neoplasms [unspecific] 25984907 "This potential path highlights the crucial role of BMP2,hsa-miR-24, AP2 and MYC as the up-stream regulators of the path and hsa-miR-215 and TYMS as potential indicator of chemotherapeutic benefit in STS metastasis." -other hsa-mir-24 Neoplasms [unspecific] 25984907 "This potential path highlights the crucial role of BMP2,hsa-miR-24, AP2 and MYC as the up-stream regulators of the path and hsa-miR-215 and TYMS as potential indicator of chemotherapeutic benefit in STS metastasis." -other hsa-mir-126 "Diabetes Mellitus, Type 2" 25986735 Circulating miR-126 is a potential biomarker to predict the onset of type 2 diabetes mellitus in susceptible individuals. -other hsa-mir-10b "Carcinoma, Lung, Non-Small-Cell" 25988292 microRNA miR-10b inhibition reduces cell proliferation and promotes apoptosis in non-small cell lung cancer (NSCLC) cells. -other hsa-mir-302 Glioblastoma 25991553 Expression of the miR-302/367 cluster in glioblastoma cells suppresses tumorigenic gene expression patterns and abolishes transformation related phenotypes. -other hsa-mir-367 Glioblastoma 25991553 Expression of the miR-302/367 cluster in glioblastoma cells suppresses tumorigenic gene expression patterns and abolishes transformation related phenotypes. -other hsa-mir-138 Lung Neoplasms 25994569 FOXP4 modulates tumor growth and independently associates with miR-138 in non-small cell lung cancer cells. -other hsa-mir-223 Inflammation 25997943 "we found that different doses of acute aerobic exercise induced a distinct and specific c-inflammamiR response, which may be associated with control of the exercise-induced inflammatory cascade. Our findings point to c-inflammamiRs as potential biomarkers of exercise-induced inflammation, and hence, exercise dose." -other hsa-mir-29a Inflammation 25997943 "we found that different doses of acute aerobic exercise induced a distinct and specific c-inflammamiR response, which may be associated with control of the exercise-induced inflammatory cascade. Our findings point to c-inflammamiRs as potential biomarkers of exercise-induced inflammation, and hence, exercise dose." -other hsa-mir-34a Inflammation 25997943 "we found that different doses of acute aerobic exercise induced a distinct and specific c-inflammamiR response, which may be associated with control of the exercise-induced inflammatory cascade. Our findings point to c-inflammamiRs as potential biomarkers of exercise-induced inflammation, and hence, exercise dose." -other hsa-mir-424 Inflammation 25997943 "we found that different doses of acute aerobic exercise induced a distinct and specific c-inflammamiR response, which may be associated with control of the exercise-induced inflammatory cascade. Our findings point to c-inflammamiRs as potential biomarkers of exercise-induced inflammation, and hence, exercise dose." -other hsa-mir-193b "Carcinoma, Hepatocellular" 25997995 miR-193b acts as a cisplatin sensitizer via the caspase-3-dependent pathway in HCC chemotherapy. -other hsa-mir-126 Neoplasms [unspecific] 25999416 "This pioneering work was followed by studies that reported intercellular exchange of miRs-143/145 and miR-21* within the vascular wall and the myocardium, respectively." -other hsa-mir-143 Neoplasms [unspecific] 25999416 "This pioneering work was followed by studies that reported intercellular exchange of miRs-143/145 and miR-21* within the vascular wall and the myocardium, respectively." -other hsa-mir-145 Neoplasms [unspecific] 25999416 "This pioneering work was followed by studies that reported intercellular exchange of miRs-143/145 and miR-21* within the vascular wall and the myocardium, respectively." -other hsa-mir-206 "Muscular Dystrophy, Duchenne" 25999854 "In contrast, local expression of mIGF-1 promotes the modulation of other microRNAs, such as miR-206 and miR-24, along with the modulation of muscle specific genes" -other hsa-mir-29a Influenza 26000345 "With assay optimization, the detection limit of our MARS assay for miR-29a-3p was found to be 1 nM, and this new assay could be completed within 1 hour without thermal cycling. This non-PCR assay with high selectivity for mature microRNA provides a new platform for rapid disease diagnosis, quarantine and disease control." -other hsa-mir-205 "Carcinoma, Lung, Non-Small-Cell" 26001154 the MiR-205 can also increase in the case with severe inflammation and benign tumor.3 The possibility of false-positive because of noncancerous lesion has to be further studied. -other hsa-mir-205 Lung Neoplasms 26001155 Reply to MiR-205 and miR-375 microRNA Assays to Distinguish Squamous Cell Carcinoma From Adenocarcinoma in Lung Cancer Biopsies. -other hsa-mir-375 Lung Neoplasms 26001155 Reply to MiR-205 and miR-375 microRNA Assays to Distinguish Squamous Cell Carcinoma From Adenocarcinoma in Lung Cancer Biopsies. -other hsa-mir-126 Atherosclerosis 26001902 "Conversely, CXCL12 expression can be induced by miR-126 in ECs through an auto-amplifying feedback loop to facilitate endothelial regeneration, thus limiting atherosclerosis and mediating plaque stabilization." -other hsa-mir-129 Inflammatory Bowel Diseases 26003847 "TLR9 aptamers may hence potentiate miRNA regulation that enhances cholinergic signaling and the resolution of inflammation, which opens new venues for manipulating bowel diseases." -other hsa-mir-186 Inflammatory Bowel Diseases 26003847 "TLR9 aptamers may hence potentiate miRNA regulation that enhances cholinergic signaling and the resolution of inflammation, which opens new venues for manipulating bowel diseases." -other hsa-mir-200c Inflammatory Bowel Diseases 26003847 "TLR9 aptamers may hence potentiate miRNA regulation that enhances cholinergic signaling and the resolution of inflammation, which opens new venues for manipulating bowel diseases." -other hsa-mir-338 "Squamous Cell Carcinoma, Esophageal" 26004521 MicroRNA-338-3p suppresses tumor growth of esophageal squamous cell carcinoma in vitro and in vivo. -other hsa-mir-101 Neoplasms [unspecific] 26005707 "eight miRNAs including miR-17-5p, miR-20a, miR-223, miR-21, miR-155, miR-494, miR-690 and miR-101 are of particular interest regarding MDSC accumulation and function." -other hsa-mir-137 Schizophrenia 26005852 The schizophrenia risk gene product miR-137 alters presynaptic plasticity. -other hsa-mir-21 "Carcinoma, Thyroid, Papillary" 26007293 MiR-9 and miR-21 as prognostic biomarkers for recurrence in papillary thyroid cancer. -other hsa-mir-9 "Carcinoma, Thyroid, Papillary" 26007293 MiR-9 and miR-21 as prognostic biomarkers for recurrence in papillary thyroid cancer. -other hsa-mir-21 "Carcinoma, Breast" 26008976 Our data revealed tissue specific changes of extracellular circulating miRNAs that would be otherwise unraveled using blood samples. -other hsa-mir-145 Gastric Neoplasms 26010149 Reverse Correlation between MicroRNA-145 and FSCN1 Affecting Gastric Cancer Migration and Invasion. -other hsa-mir-21 Cervicitis 26010154 Up-Regulation of miR-21 Is Associated with Cervicitis and Human Papillomavirus Infection in Cervical Tissues. -other hsa-mir-15 "Leukemia, Lymphocytic, Chronic, B-Cell" 26010203 "A rare but recurrent t(8;13)(q24;q14) translocation in B-cell chronic lymphocytic leukaemia causing MYC up-regulation and concomitant loss of PVT1, miR-15/16 and DLEU7." -other hsa-mir-16 "Leukemia, Lymphocytic, Chronic, B-Cell" 26010203 "A rare but recurrent t(8;13)(q24;q14) translocation in B-cell chronic lymphocytic leukaemia causing MYC up-regulation and concomitant loss of PVT1, miR-15/16 and DLEU7." -other hsa-mir-200b Lung Neoplasms 26012256 Nobiletin inhibited hypoxia-induced epithelial-mesenchymal transition of lung cancer cells by inactivating of Notch-1 signaling and switching on miR-200b. -other hsa-mir-20a "Carcinoma, Colon" 26012475 The Effects of miR-20a on p21: Two Mechanisms Blocking Growth Arrest in TGF-¦Â-Responsive Colon Carcinoma. -other hsa-mir-467 Breast Neoplasms 26018675 Inhibition of hyperglycemia-induced angiogenesis and breast cancer tumor growth by systemic injection of microRNA-467 antagonist. -other hsa-mir-1 "Carcinoma, Hepatocellular" 26019452 "MiR-1 might be a potential tumor activator. Inhibiting its expression could decrease proliferation, induce apoptosis, and inhibit the migration and invasion of TECs of human HCC." -other hsa-mir-24 Hyperglycemia 26022048 "In this issue of Blood, Xiang et al identify a novel mechanism, involving activation of the polyol pathway and repression of microRNA-24 (miR-24), through which hyperglycemia augments von Willebrand factor (VWF) expression and secretion." -other hsa-mir-15b "Carcinoma, Hepatocellular" 26023735 "miR-15b-5p induces endoplasmic reticulum stress and apoptosis in human hepatocellular carcinoma, both in vitro and in vivo, by suppressing Rab1A." -other hsa-mir-218 "Carcinoma, Hepatocellular" 26024833 "Hotair silence activates P16(Ink4a) and P14(ARF) signaling by enhancing miR-218 expression and suppressing Bmi-1 expression, resulting in the suppression of tumorigenesis in HCC." -other hsa-mir-1202 Mandibular Prognathism 26025627 "Our results indicated a possible association between the differentially expressed miRNAs and MP pathogenesis, and the precise mechanisms are needed to be further validated." -other hsa-mir-629 Mandibular Prognathism 26025627 "Our results indicated a possible association between the differentially expressed miRNAs and MP pathogenesis, and the precise mechanisms are needed to be further validated." -other hsa-mir-638 Mandibular Prognathism 26025627 "Our results indicated a possible association between the differentially expressed miRNAs and MP pathogenesis, and the precise mechanisms are needed to be further validated." -other hsa-mir-143 Colon Neoplasms 26025964 The data also showed that the restoration of hsa-miR-143 expression in SW480 leads to a significant translation repression of the introduced reporter and suicide genes. -other hsa-mir-21 Breast Neoplasms 26026077 miR-21 is a potential biomarker for breast cancer prognosis. -other hsa-mir-27 "Carcinoma, Esophageal" 26026166 miR-27 is associated with chemoresistance in esophageal cancer through transformation of normal fibroblasts to cancer-associated fibroblasts. -other hsa-mir-138 Nervous System Diseases [unspecific] 26026282 "Many studies have emerged which link miRNAs with OL and myelin pathology in various central nervous system (CNS) diseases including multiple sclerosis (MS), ischemic stroke,spinal cord injury, and adult-onset autosomal dominant leukodystrophy (ADLD)." -other hsa-mir-219 Nervous System Diseases [unspecific] 26026282 "Many studies have emerged which link miRNAs with OL and myelin pathology in various central nervous system (CNS) diseases including multiple sclerosis (MS), ischemic stroke,spinal cord injury, and adult-onset autosomal dominant leukodystrophy (ADLD)." -other hsa-mir-338 Nervous System Diseases [unspecific] 26026282 "Many studies have emerged which link miRNAs with OL and myelin pathology in various central nervous system (CNS) diseases including multiple sclerosis (MS), ischemic stroke,spinal cord injury, and adult-onset autosomal dominant leukodystrophy (ADLD)." -other hsa-mir-9 Nervous System Diseases [unspecific] 26026282 "Many studies have emerged which link miRNAs with OL and myelin pathology in various central nervous system (CNS) diseases including multiple sclerosis (MS), ischemic stroke,spinal cord injury, and adult-onset autosomal dominant leukodystrophy (ADLD)." -other hsa-let-7a Lung Neoplasms 26026830 "According to our literature survey and database validation, many of these results are biologically meaningful for understanding the mechanism of the complex post-transcriptional regulations in lung cancer." -other hsa-let-7b Lung Neoplasms 26026830 "According to our literature survey and database validation, many of these results are biologically meaningful for understanding the mechanism of the complex post-transcriptional regulations in lung cancer." -other hsa-let-7c Lung Neoplasms 26026830 "According to our literature survey and database validation, many of these results are biologically meaningful for understanding the mechanism of the complex post-transcriptional regulations in lung cancer." -other hsa-let-7f Lung Neoplasms 26026830 "According to our literature survey and database validation, many of these results are biologically meaningful for understanding the mechanism of the complex post-transcriptional regulations in lung cancer." -other hsa-mir-17 Feingold Syndrome 26026879 "respectively, of miR-17-92?/+ in comparison with WT mice, thus suggesting a possible link between cognitive deficits and altered brain neurotransmission" -other hsa-mir-18 Feingold Syndrome 26026879 "respectively, of miR-17-92?/+ in comparison with WT mice, thus suggesting a possible link between cognitive deficits and altered brain neurotransmission" -other hsa-mir-19a Feingold Syndrome 26026879 "respectively, of miR-17-92?/+ in comparison with WT mice, thus suggesting a possible link between cognitive deficits and altered brain neurotransmission" -other hsa-mir-19b-1 Feingold Syndrome 26026879 "respectively, of miR-17-92?/+ in comparison with WT mice, thus suggesting a possible link between cognitive deficits and altered brain neurotransmission" -other hsa-mir-20a Feingold Syndrome 26026879 "respectively, of miR-17-92?/+ in comparison with WT mice, thus suggesting a possible link between cognitive deficits and altered brain neurotransmission" -other hsa-mir-92-1 Feingold Syndrome 26026879 "respectively, of miR-17-92?/+ in comparison with WT mice, thus suggesting a possible link between cognitive deficits and altered brain neurotransmission" -other hsa-mir-21 Lung Neoplasms 26026961 Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR-mutated lung cancer via nickel-induced microRNA-21 expression. -other hsa-mir-125b Narcolepsy 26028057 "we would suggest the possible overexpression of these miRNAs subtypes in N1 patients close to disease onset. Yet, larger investigations are needed in the future to better determine if there is a causal association among inflammation, miRNAs, and narcolepsy." -other hsa-mir-130a Narcolepsy 26028057 "we would suggest the possible overexpression of these miRNAs subtypes in N1 patients close to disease onset. Yet, larger investigations are needed in the future to better determine if there is a causal association among inflammation, miRNAs, and narcolepsy." -other hsa-mir-155 Narcolepsy 26028057 "we would suggest the possible overexpression of these miRNAs subtypes in N1 patients close to disease onset. Yet, larger investigations are needed in the future to better determine if there is a causal association among inflammation, miRNAs, and narcolepsy." -other hsa-mir-26a Narcolepsy 26028057 "we would suggest the possible overexpression of these miRNAs subtypes in N1 patients close to disease onset. Yet, larger investigations are needed in the future to better determine if there is a causal association among inflammation, miRNAs, and narcolepsy." -other hsa-mir-30c Narcolepsy 26028057 "we would suggest the possible overexpression of these miRNAs subtypes in N1 patients close to disease onset. Yet, larger investigations are needed in the future to better determine if there is a causal association among inflammation, miRNAs, and narcolepsy." -other hsa-mir-663 "Adenocarcinoma, Pancreatic Ductal" 26028359 MicroRNA-663 activates the canonical Wnt signaling through the adenomatous polyposis coli suppression. -other hsa-mir-21 "Squamous Cell Carcinoma, Skin or Unspecific" 26029210 "Conversely, small HA-CD44 interaction stimulates RhoA activation, NFκB/Stat-3 signaling, and miR-21 production, resulting in inflammation and proliferation as well as SCC progression." -other hsa-mir-302 Nervous System Diseases [unspecific] 26030913 These results show that neuroblasts can be generated directly from adult human and mouse astrocytes by miR-302/367-driven induction. This approach seems promising for converting glial scar cells into neuroblasts in a wide range of neurological diseases. -other hsa-mir-367 Nervous System Diseases [unspecific] 26030913 These results show that neuroblasts can be generated directly from adult human and mouse astrocytes by miR-302/367-driven induction. This approach seems promising for converting glial scar cells into neuroblasts in a wide range of neurological diseases. -other hsa-mir-16 Neoplasms [unspecific] 26031775 Our findings provide the first clues regarding the role of miR-16 as a tumor suppressor in cancer cells through the inhibition of FEAT translation. -other hsa-mir-208 Prostate Neoplasms 26032092 Curcumin inhibits growth of prostate carcinoma via miR-208-mediated CDKN1A activation. -other hsa-mir-20a Multiple Myeloma 26032093 Expressions of miR-181a and miR-20a in RPMI8226 cell line and their potential as biomarkers for multiple myeloma. -other hsa-mir-200 "Diabetes Mellitus, Type 2" 26032109 Preventing ¦Â-cell apoptosis and T2DM with microRNAs--a role for miR-200 -other hsa-mir-320e Colorectal Carcinoma 26035698 "In two clinical trial cohorts, a systematic biomarker discovery and validation approach identified miR-320e to be a novel prognostic biomarker that is associated with adverse clinical outcome in stage III CRC patients treated with 5-FU-based adjuvant chemotherapy. These findings have important implications for the personalised management of CRC patients." -other hsa-mir-185 Pituitary Adenoma 26036598 MiR-185 enhanced the cell proliferation and inhibited the apoptosis of GH3 cells. -other hsa-mir-1 "Carcinoma, Renal Cell, Clear-Cell" 26036633 MiR-1 downregulation correlates with poor survival in clear cell renal cell carcinoma where it interferes with cell cycle regulation and metastasis. -other hsa-mir-323b Hepatitis B Virus Infection 26037063 The association between microRNA-323b polymorphism and hepatitis B virus persistent infection - some problems should be addressed. -other hsa-mir-323b Hepatitis B Virus Infection 26037064 The association between microRNA-323b polymorphism and hepatitis B virus persistent infection - some problems should be addressed. -other hsa-mir-17 "Leukemia, Myeloid, Acute" 26038136 "CDK inhibitor SNS-032 can induce apoptosis of AML HL-60 cells, which is associated with the inhibition of MCL-1,C-MYC and JAK2/STAT3, and down-regulation of miR-17-92 family." -other hsa-mir-103 Myocardial Infarction 26038570 "Our results reveal a novel myocardial necrosis regulation model,which is composed of H19, miR-103/107, and FADD. Modulation of their levels may provide a new approach for preventing myocardial necrosis." -other hsa-mir-107 Myocardial Infarction 26038570 "Our results reveal a novel myocardial necrosis regulation model,which is composed of H19, miR-103/107, and FADD. Modulation of their levels may provide a new approach for preventing myocardial necrosis." -other hsa-mir-494 Lung Neoplasms 26040900 Tumor-derived microRNA-494 promotes angiogenesis in non-small cell lung cancer. -other hsa-mir-29c Renal Fibrosis 26040904 "Overall, miR-29c correlated with the degree of renal chronicity but not with renal function, suggesting it could be used as a novel non-invasive marker of early progression to fibrosis in patients with LN." -other hsa-mir-17 Leukemia 26041742 Microenvironmental interleukin-6 suppresses toll-like receptor signaling in human leukemia cells through miR-17/19A. -other hsa-mir-19a Leukemia 26041742 Microenvironmental interleukin-6 suppresses toll-like receptor signaling in human leukemia cells through miR-17/19A. -other hsa-mir-124 Nervous System Diseases [unspecific] 26041995 "the link between dysregulation of miR-124 and CNS disorders, such as neurodegeneration, CNS stress, neuroimmune disorders, stroke, and brain tumors, has become evident" -other hsa-mir-130a "Carcinoma, Ovarian" 26043084 MiR-130a and MiR-374a Function as Novel Regulators of Cisplatin Resistance in Human Ovarian Cancer A2780 Cells. -other hsa-mir-374a "Carcinoma, Ovarian" 26043084 MiR-130a and MiR-374a Function as Novel Regulators of Cisplatin Resistance in Human Ovarian Cancer A2780 Cells. -other hsa-mir-449b "Carcinoma, Thyroid" 26044563 Regulation of MET-mediated proliferation of thyroid carcinoma cells by miR-449b. -other hsa-mir-191 Acute Myocardial Infarction 26044724 "miR-208b was significantly increased in the AMI compared with healthy people, while miR-26a and miR-191 were decreased. miR-26a, miR-191, and miR-208b were potential indices of AMI, and miR-208b was more effective in patients with non-ST-elevation myocardial infarction." -other hsa-mir-208b Acute Myocardial Infarction 26044724 "miR-208b was significantly increased in the AMI compared with healthy people, while miR-26a and miR-191 were decreased. miR-26a, miR-191, and miR-208b were potential indices of AMI, and miR-208b was more effective in patients with non-ST-elevation myocardial infarction." -other hsa-mir-26a Acute Myocardial Infarction 26044724 "miR-208b was significantly increased in the AMI compared with healthy people, while miR-26a and miR-191 were decreased. miR-26a, miR-191, and miR-208b were potential indices of AMI, and miR-208b was more effective in patients with non-ST-elevation myocardial infarction." -other hsa-mir-24 Gastric Neoplasms 26045155 These results suggest that the measurement of miR-24 expression from formalin-fixed paraffin-embedded (FFPE) samples is useful to identify radiation-associated GC. -other hsa-mir-374b Colorectal Carcinoma 26045793 The potential value of miR-1 and miR-374b as biomarkers for colorectal cancer. -other hsa-mir-27a "Carcinoma, Renal Cell, Clear-Cell" 26046464 Expression of miR-27a-3p is an independent predictive factor for recurrence in clear cell renal cell carcinoma. -other hsa-mir-106b Breast Neoplasms 26046581 These observations have been validated using an independent publicly available breast cancer dataset from The Cancer Genome Atlas. -other hsa-mir-148a Breast Neoplasms 26046581 These observations have been validated using an independent publicly available breast cancer dataset from The Cancer Genome Atlas. -other hsa-mir-15 Breast Neoplasms 26046581 These observations have been validated using an independent publicly available breast cancer dataset from The Cancer Genome Atlas. -other hsa-mir-16 Breast Neoplasms 26046581 These observations have been validated using an independent publicly available breast cancer dataset from The Cancer Genome Atlas. -other hsa-mir-17 Breast Neoplasms 26046581 These observations have been validated using an independent publicly available breast cancer dataset from The Cancer Genome Atlas. -other hsa-mir-18 Breast Neoplasms 26046581 These observations have been validated using an independent publicly available breast cancer dataset from The Cancer Genome Atlas. -other hsa-mir-19a Breast Neoplasms 26046581 These observations have been validated using an independent publicly available breast cancer dataset from The Cancer Genome Atlas. -other hsa-mir-19b-1 Breast Neoplasms 26046581 These observations have been validated using an independent publicly available breast cancer dataset from The Cancer Genome Atlas. -other hsa-mir-20a Breast Neoplasms 26046581 These observations have been validated using an independent publicly available breast cancer dataset from The Cancer Genome Atlas. -other hsa-mir-29a Breast Neoplasms 26046581 These observations have been validated using an independent publicly available breast cancer dataset from The Cancer Genome Atlas. -other hsa-mir-29c Breast Neoplasms 26046581 These observations have been validated using an independent publicly available breast cancer dataset from The Cancer Genome Atlas. -other hsa-mir-92-1 Breast Neoplasms 26046581 These observations have been validated using an independent publicly available breast cancer dataset from The Cancer Genome Atlas. -other hsa-mir-21 Heart Failure 26047574 "Torasemide but not furosemide inhibits CYP11B2 activity and reduces the expression of CTGF, LOX, and miR-21." -other hsa-mir-1264 Atherosclerosis 26047583 This could be a causative epigenetic mechanism associated with TNF-¦Á and IGF-1 induced smooth muscle cell proliferation involved in the pathogenesis of coronary artery hyperplasia and restenosis. -other hsa-mir-126 Parkinson Disease 26047984 "Our study provides evidence for a general association of miRNAs with the cellular function and identity of SN DA neurons, and with deregulated gene expression networks and signaling pathways related to PD pathogenesis that may be sex-specific." -other hsa-mir-21 "Carcinoma, Cervical" 26051842 "Overall, our study suggests that the microRNAs, miR-21 and let-7a function as clinically relevant integral components of STAT3 signaling and are responsible for maintaining activated state of STAT3 in HPV-infected cells during cervical carcinogenesis." -other hsa-mir-196a Neuroendocrine Tumors 26052033 Roles of miR-196a on gene regulation of neuroendocrine tumor cells. -other hsa-mir-22 Prostate Neoplasms 26052614 miR-22 and miR-29a Are Members of the Androgen Receptor Cistrome Modulating LAMC1 and Mcl-1 in Prostate Cancer. -other hsa-mir-29a Prostate Neoplasms 26052614 miR-22 and miR-29a Are Members of the Androgen Receptor Cistrome Modulating LAMC1 and Mcl-1 in Prostate Cancer. -other hsa-mir-32 Colorectal Carcinoma 26054686 Oridonin triggers apoptosis in colorectal carcinoma cells and suppression of microRNA-32 expression augments oridonin-mediated apoptotic effects. -other hsa-mir-155 Systemic Lupus Erythematosus 26055806 "We demonstrate that SLE patients have reduced IL-21 signaling capacity, decreased miR-155 levels, and increased SOCS1 levels compared to HCs.The reduced IL-21 signaling in SLE could be rescued by overexpression of miR-155,suggesting an important role for miR-155 in the reduced IL-21 signaling observed in SLE." -other hsa-mir-204 Coloboma 26056285 MiR-204 is responsible for inherited retinal dystrophy associated with ocular coloboma. -other hsa-mir-30e Breast Neoplasms 26057454 We highlighted a relevant and subtype-specific role in breast cancer for miR-30e* and demonstrated that adding miRNA markers to gene signatures and clinico-pathological features can help for a better prognostication. -other hsa-mir-21 "Carcinoma, Hepatocellular" 26060089 "Our results demonstrate that cisplatin inhibits the growth of HCC, possibly through the induction of G1 cell cycle arrest and apoptosis through the alteration of microRNA expression." -other hsa-mir-338 "Carcinoma, Hepatocellular" 26060089 "Our results demonstrate that cisplatin inhibits the growth of HCC, possibly through the induction of G1 cell cycle arrest and apoptosis through the alteration of microRNA expression." -other hsa-mir-34a "Carcinoma, Hepatocellular" 26060089 "Our results demonstrate that cisplatin inhibits the growth of HCC, possibly through the induction of G1 cell cycle arrest and apoptosis through the alteration of microRNA expression." -other hsa-mir-99a "Carcinoma, Hepatocellular" 26060089 "Our results demonstrate that cisplatin inhibits the growth of HCC, possibly through the induction of G1 cell cycle arrest and apoptosis through the alteration of microRNA expression." -other hsa-mir-130a Hepatitis C Virus Infection 26060358 Vitamin D Potentiates the Inhibitory Effect of MicroRNA-130a in Hepatitis C Virus Replication Independent of Type I Interferon Signaling Pathway. -other hsa-mir-181c Osteosarcoma 26062442 miR-181c associates with tumor relapse of high grade osteosarcoma. -other hsa-mir-217 Osteosarcoma 26062553 Quercetin Enhances Cisplatin Sensitivity of Human Osteosarcoma Cells by Modulating microRNA-217-KRAS Axis. -other hsa-mir-215 "Carcinoma, Pancreatic" 26063036 miR-215 overexpression distinguishes ampullary carcinomas from pancreatic carcinomas. -other hsa-mir-513c Glioblastoma 26063413 microRNA-513c suppresses the proliferation of human glioblastoma cells by repressing low-density lipoprotein receptor-related protein 6. -other hsa-mir-146b Oral Lichen Planus 26064947 The TF-miRNA Coregulation Network in Oral Lichen Planus. -other hsa-mir-190 Oral Lichen Planus 26064947 The TF-miRNA Coregulation Network in Oral Lichen Planus. -other hsa-mir-26b Oral Lichen Planus 26064947 The TF-miRNA Coregulation Network in Oral Lichen Planus. -other hsa-mir-29a Oral Lichen Planus 26064947 The TF-miRNA Coregulation Network in Oral Lichen Planus. -other hsa-mir-595 Oral Lichen Planus 26064947 The TF-miRNA Coregulation Network in Oral Lichen Planus. -other hsa-mir-628 Oral Lichen Planus 26064947 The TF-miRNA Coregulation Network in Oral Lichen Planus. -other hsa-mir-205 Oral Leukoplakia 26064958 Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia. -other hsa-mir-21 Oral Leukoplakia 26064958 Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia. -other hsa-mir-323 Oral Leukoplakia 26064958 Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia. -other hsa-mir-423 Oral Leukoplakia 26064958 Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia. -other hsa-mir-491 Oral Leukoplakia 26064958 Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia. -other hsa-mir-499 Oral Leukoplakia 26064958 Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia. -other hsa-mir-525 Oral Leukoplakia 26064958 Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia. -other hsa-mir-549 Oral Leukoplakia 26064958 Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia. -other hsa-mir-155 "Carcinoma, Renal Cell" 26064968 miR-155 and miR-484 Are Associated with Time to Progression in Metastatic Renal Cell Carcinoma Treated with Sunitinib. -other hsa-mir-484 "Carcinoma, Renal Cell" 26064968 miR-155 and miR-484 Are Associated with Time to Progression in Metastatic Renal Cell Carcinoma Treated with Sunitinib. -other hsa-mir-1 Myocardial Infarction 26065643 spironolactone could increase miRNA-1 expression in ischemic rat myocardium after MI -other hsa-mir-199a Colorectal Carcinoma 26065676 "It was found that miR-199a would reduce the proliferation, migration and invasion. However, overexpression of miR-199a on the apoptosis rate and cell cycles showed no significant results. The potential functionary mechanism of miR-199a might through HIF-1¦Á/VEGF pathway." -other hsa-mir-27b Breast Neoplasms 26065921 Loss of microRNA-27b contributes to breast cancer stem cell generation by activating ENPP1. -other hsa-mir-7 Viral Infectious Disease 26067353 "Results of this study identify a molecular mechanism of RNAi for antiviral defense, and extend our knowledge of the complex interplay between host and PV, which will provide a basis for the development of effective RNAi-based therapies designed to inhibit PV replication and protect host cells." -other hsa-mir-101 Prostate Neoplasms 26067553 RLIP76-dependent suppression of PI3K/AKT/Bcl-2 pathway by miR-101 induces apoptosis in prostate cancer. -other hsa-mir-200 Breast Neoplasms 26068592 "The upregulation of fibronectin and lysyl oxidase directly by miR-200 or indirectly through Fli-1 or TCF12 contributed to ECM remodeling, triggering the invasion and metastasis of breast cancer cells both in vitro and vivo" -other hsa-mir-205 "Adenocarcinoma, Lung" 26068980 "Surprisingly, expression of classifier miR-205 was intermediate between that of classical adenocarcinoma and squamous cell carcinoma suggesting that adenosquamous carcinoma is a transitional stage between these tumor types." -other hsa-mir-200 Neoplasms [unspecific] 26069247 Network-Based Approaches to Understand the Roles of miR-200 and Other microRNAs in Cancer. -other hsa-mir-184 Breast Neoplasms 26070602 These studies elucidate a new layer of regulation in the PI3K/AKT/mTOR pathway with relevance to mammary development and tumour progression and identify miR-184 as a putative breast tumour suppressor. -other hsa-mir-433 Parkinson Disease 26070653 Variation in the miRNA-433 binding site of FGF20 is a risk factor for Parkinson's disease in Iranian population. -other hsa-mir-101 Colorectal Carcinoma 26071354 MicroRNA-101 down-regulates sphingosine kinase 1 in colorectal cancer cells. -other hsa-mir-155 Infection [unspecific] 26072128 An update on the role of miRNA-155 in pathogenic microbial infections. -other hsa-mir-145 Chromosome 5q Deletion Syndrome 26075044 Loss of the microRNA genes miR-145 and miR-146a has been associated with the thrombocytosis observed in 5q- syndrome patients. -other hsa-mir-146a Chromosome 5q Deletion Syndrome 26075044 Loss of the microRNA genes miR-145 and miR-146a has been associated with the thrombocytosis observed in 5q- syndrome patients. -other hsa-mir-206 Lung Neoplasms 26075299 Comprehensive gene and microRNA expression profiling reveals miR-206 inhibits MET in lung cancer metastasis. -other hsa-mir-150 Acute Myocardial Infarction 26077801 "Results indicated that the levels of circulating miR-486 and miR-150 are associated with AMI. They may be novel and powerful biomarkers for AMI,especially for NSTEMI." -other hsa-mir-486 Acute Myocardial Infarction 26077801 "Results indicated that the levels of circulating miR-486 and miR-150 are associated with AMI. They may be novel and powerful biomarkers for AMI,especially for NSTEMI." -other hsa-mir-191 Prostate Neoplasms 26078486 "Our results proved miR-191 to be the most stable gene, showing the lowest degree of variation and the highest stability value.miR-25 and SNORD48 values fell beyond the cutoff of acceptability. In conclusion,we recommend the use of miR-191 for normalization purposes in post-DRE urine sediments." -other hsa-mir-25 Prostate Neoplasms 26078486 "Our results proved miR-191 to be the most stable gene, showing the lowest degree of variation and the highest stability value.miR-25 and SNORD48 values fell beyond the cutoff of acceptability. In conclusion,we recommend the use of miR-191 for normalization purposes in post-DRE urine sediments." -other hsa-mir-210 Lung Disease [unspecific] 26079696 this study demonstrates the added value of an integrated miRNA-mRNA approach for identifying molecular events altered by environmental pollutants in an in vitro human model. -other hsa-let-7 Neoplasms [unspecific] 26080928 these results suggest that cytoplasmic uridylation pathway actively participates in blockade of let-7 biogenesis by Lin28B. -other hsa-mir-184 Hepatoblastoma 26081234 miRNA-184 lentivirus-mediated human lens epithelial cells (HLEC) can inhibit the occurrence of epithelial-mesenchymal transition (EMT). -other hsa-mir-222 Inflammation 26081516 "In pathological hyperglycaemic conditions, EMP-mediated miR-222-dependent anti-inflammatory effects are reduced." -other hsa-mir-449a Prostate Neoplasms 26081756 Capsaicin causes inactivation and degradation of the androgen receptor by inducing the restoration of miR-449a in prostate cancer. -other hsa-mir-337 Neuroblastoma 26084291 miRNA-337-3p suppresses neuroblastoma progression by repressing the transcription of matrix metalloproteinase 14. -other hsa-mir-223 Pulmonary Hypertension 26084306 miR-223 reverses experimental pulmonary arterial hypertension. -other hsa-mir-502 Colorectal Carcinoma 26086375 "While the approach is here validated for CRC, the implementation of disease-specific miRNA target prediction algorithms can be easily adopted for other applications too. The identification of disease-specific miRNA target interactions may also facilitate the identification of potential drug targets." -other hsa-mir-650 Colorectal Carcinoma 26086375 "While the approach is here validated for CRC, the implementation of disease-specific miRNA target prediction algorithms can be easily adopted for other applications too. The identification of disease-specific miRNA target interactions may also facilitate the identification of potential drug targets." -other hsa-mir-7 Colorectal Carcinoma 26086375 "While the approach is here validated for CRC, the implementation of disease-specific miRNA target prediction algorithms can be easily adopted for other applications too. The identification of disease-specific miRNA target interactions may also facilitate the identification of potential drug targets." -other hsa-mir-760 Colorectal Carcinoma 26086375 "While the approach is here validated for CRC, the implementation of disease-specific miRNA target prediction algorithms can be easily adopted for other applications too. The identification of disease-specific miRNA target interactions may also facilitate the identification of potential drug targets." -other hsa-mir-93 Colorectal Carcinoma 26086375 "While the approach is here validated for CRC, the implementation of disease-specific miRNA target prediction algorithms can be easily adopted for other applications too. The identification of disease-specific miRNA target interactions may also facilitate the identification of potential drug targets." -other hsa-mir-101 Inflammation 26087518 "Advances in understanding the roles of microRNA-101 in inflammation, fibrosis and cancer" -other hsa-mir-93 "Carcinoma, Ovarian" 26087719 The results suggested that berberine modulated the sensitivity of cisplatin through miR-93/PTEN/AKT signaling pathway in the ovarian cancer cells. -other hsa-mir-22 Inflammation 26088024 extracellular Adenosine and uridine triphosphate (ATP and UTP) can attenuate ICAM-1 expression and leukocyte adhesion in endothelial cells through miR-22. -other hsa-mir-200a Breast Neoplasms 26088362 miR-200a inhibits migration of triple-negative breast cancer cells through direct repression of the EPHA2 oncogene. -other hsa-mir-133a Prostate Neoplasms 26089375 "Our data suggest that AA-specific/-enriched miRNA-mRNA pairings may play a critical role in the activation of oncogenic pathways in AA prostate cancer. Our findings also suggest that miR-133a/MCL1, miR-513c/STAT1, and miR-96/FOXO3A may have clinical significance in the development of novel strategies for treating aggressive prostate cancer." -other hsa-mir-145 Prostate Neoplasms 26089375 "Our data suggest that AA-specific/-enriched miRNA-mRNA pairings may play a critical role in the activation of oncogenic pathways in AA prostate cancer. Our findings also suggest that miR-133a/MCL1, miR-513c/STAT1, and miR-96/FOXO3A may have clinical significance in the development of novel strategies for treating aggressive prostate cancer." -other hsa-mir-34a Prostate Neoplasms 26089375 "Our data suggest that AA-specific/-enriched miRNA-mRNA pairings may play a critical role in the activation of oncogenic pathways in AA prostate cancer. Our findings also suggest that miR-133a/MCL1, miR-513c/STAT1, and miR-96/FOXO3A may have clinical significance in the development of novel strategies for treating aggressive prostate cancer." -other hsa-mir-513c Prostate Neoplasms 26089375 "Our data suggest that AA-specific/-enriched miRNA-mRNA pairings may play a critical role in the activation of oncogenic pathways in AA prostate cancer. Our findings also suggest that miR-133a/MCL1, miR-513c/STAT1, and miR-96/FOXO3A may have clinical significance in the development of novel strategies for treating aggressive prostate cancer." -other hsa-mir-96 Prostate Neoplasms 26089375 "Our data suggest that AA-specific/-enriched miRNA-mRNA pairings may play a critical role in the activation of oncogenic pathways in AA prostate cancer. Our findings also suggest that miR-133a/MCL1, miR-513c/STAT1, and miR-96/FOXO3A may have clinical significance in the development of novel strategies for treating aggressive prostate cancer." -other hsa-mir-9 "Lymphoma, Hodgkin" 26089393 We report a high-resolution time series study of transcriptome dynamics following antimiR-mediated inhibition of miR-9 in a Hodgkin lymphoma cell-line-the first such dynamic study of the microRNA inhibition response-revealing both general and specific aspects of the physiological response. -other hsa-mir-221 Hepatitis C Virus Infection 26090579 IFN-¦Á-Induced Downregulation of miR-221 in Dendritic Cells: Implications for HCV Pathogenesis and Treatment. -other hsa-mir-34a Toxic Encephalopathy 26091620 We also found that inhibition of astrocytic miR-34a after Lipopolysaccharide(LPS) stimulation can postpone dopaminergic neuron loss under neurotoxin stress. -other hsa-mir-29 Pancreatic Neoplasms 26095125 Pathophysiological role of microRNA-29 in pancreatic cancer stroma. -other hsa-mir-146a Breast Neoplasms 26095299 "our study provided new insights into the function of CXCR4 in breast cancer: it promotes tumor progression as both a protein-coding gene and a non-coding RNA, complicating the mechanism by which oncogenes promote tumor progression." -other hsa-mir-137 Intellectual Disability 26095359 "Our findings suggest that miR-137 is a key factor in the control of synaptic efficacy and mGluR-dependent synaptic plasticity, supporting the notion that glutamatergic dysfunction contributes to the pathogenesis of miR-137-linked cognitive impairments." -other hsa-mir-150 Myasthenia Gravis 26095457 "The immuno-microRNAs miR-150-5p and miR-21-5p show a disease specific signature, which suggests these microRNAs as possible biological autoimmune markers of myasthenia gravis (MG)." -other hsa-mir-21 Myasthenia Gravis 26095457 "The immuno-microRNAs miR-150-5p and miR-21-5p show a disease specific signature, which suggests these microRNAs as possible biological autoimmune markers of myasthenia gravis (MG)." -other hsa-mir-122 Hepatitis C Virus Infection 26096908 Hepatitis C virus addiction to liver miR-122 takes its Toll on the host. -other hsa-mir-29b Spinal Cord Injuries 26097563 Combinatorial effects of miR-20a and miR-29b on neuronal apoptosis induced by spinal cord injury. -other hsa-mir-196a "Carcinoma, Ovarian" 26097603 "In conclusion, miR-196a may play an important role in the progression of ovarian carcinoma, and could be used as an independent prognostic biomarker for patients with ovarian carcinoma." -other hsa-mir-19 Lung Neoplasms 26098000 MicroRNA-19 triggers epithelial-mesenchymal transition of lung cancer cells accompanied by growth inhibition. -other hsa-mir-21 Neoplasms [unspecific] 26101800 The IL-6/STAT3 pathway via miR-21 is involved in the neoplastic and metastatic properties of arsenite-transformed human keratinocytes. -other hsa-mir-21 Breast Neoplasms 26106867 Successful attempts were made in applying the approach to detect miR-21 in human cell lysate samples of breast cancer patients. -other hsa-mir-26a Obesity 26107166 These results unravel a new mechanism by which bile acid receptor TGR5 activates a miRNA gene expression. -other hsa-mir-133a Breast Neoplasms 26107945 MiR-133a Is Functionally Involved in Doxorubicin-Resistance in Breast Cancer Cells MCF-7 via Its Regulation of the Expression of Uncoupling Protein 2. -other hsa-mir-7 Lung Neoplasms 26108539 miR-7 modulates chemoresistance of small cell lung cancer by repressing MRP1/ABCC1. -other hsa-mir-21 Glioma 26109525 Tamoxifen-Induced Cell Death of Malignant Glioma Cells Is Brought About by Oxidative-Stress-Mediated Alterations in the Expression of BCL2 Family Members and Is Enhanced on miR-21 Inhibition. -other hsa-mir-23a Prostate Neoplasms 26110567 "By inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated metastatic ability in prostate cancer." -other hsa-mir-218 Neoplasms [unspecific] 26111662 Opposite effects of two estrogen receptors on tau phosphorylation through disparate effects on the miR-218/PTPA pathway. -other hsa-mir-148a Osteosarcoma 26111756 Bufalin Inhibits the Differentiation and Proliferation of Cancer Stem Cells Derived from Primary Osteosarcoma Cells through Mir-148a. -other hsa-mir-22 Liver Cirrhosis 26112332 MiR-22 promotes the development of cirrhosis through BMP7 suppression. -other hsa-mir-33a "Carcinoma, Pancreatic" 26113407 miR-33a suppresses the nuclear translocation of ¦Â-catenin to enhance gemcitabine sensitivity in human pancreatic cancer cells. -other hsa-mir-146a Coronary Artery Disease 26114385 Meta-Analysis of miR-146a Polymorphisms Association with Coronary Artery Diseases and Ischemic Stroke. -other hsa-mir-21 Lymphoma 26116372 MiR-21: an environmental driver of malignant melanoma -other hsa-mir-153 Parkinson Disease 26116522 Tanshinone IIA protects dopaminergic neurons against 6-hydroxydopamine-induced neurotoxicity through miR-153/NF-E2-related factor 2/antioxidant response element signaling pathway. -other hsa-mir-21 "Leukemia, Myelogenous, Chronic, BCR-ABL Positive" 26116834 Curcumin inhibits in vitro and in vivo chronic myelogenous leukemia cells growth:a possible role for exosomal disposal of miR-21. -other hsa-mir-17 Neoplasms [unspecific] 26117336 Oncogenic miR-17/20a Forms a Positive Feed-forward Loop with the p53 Kinase DAPK3 to Promote Tumorigenesis. -other hsa-mir-20a Neoplasms [unspecific] 26117336 Oncogenic miR-17/20a Forms a Positive Feed-forward Loop with the p53 Kinase DAPK3 to Promote Tumorigenesis. -other hsa-let-7c Pancreatic Neoplasms 26121640 "Our novel findings indicate that salivary miRNA are discriminatory in pancreatic cancer patients that are not eligible for surgery. In addition, we demonstrate in experimental models that salivary miRNA detection precedes systemic detection of cancer cells markers. This study stems for the use of salivary miRNA as biomarker for the early diagnosis of patients with unresectable pancreatic cancer." -other hsa-mir-21 Pancreatic Neoplasms 26121640 "Our novel findings indicate that salivary miRNA are discriminatory in pancreatic cancer patients that are not eligible for surgery. In addition, we demonstrate in experimental models that salivary miRNA detection precedes systemic detection of cancer cells markers. This study stems for the use of salivary miRNA as biomarker for the early diagnosis of patients with unresectable pancreatic cancer." -other hsa-mir-210 Pancreatic Neoplasms 26121640 "Our novel findings indicate that salivary miRNA are discriminatory in pancreatic cancer patients that are not eligible for surgery. In addition, we demonstrate in experimental models that salivary miRNA detection precedes systemic detection of cancer cells markers. This study stems for the use of salivary miRNA as biomarker for the early diagnosis of patients with unresectable pancreatic cancer." -other hsa-mir-216 Pancreatic Neoplasms 26121640 "Our novel findings indicate that salivary miRNA are discriminatory in pancreatic cancer patients that are not eligible for surgery. In addition, we demonstrate in experimental models that salivary miRNA detection precedes systemic detection of cancer cells markers. This study stems for the use of salivary miRNA as biomarker for the early diagnosis of patients with unresectable pancreatic cancer." -other hsa-mir-23a Pancreatic Neoplasms 26121640 "Our novel findings indicate that salivary miRNA are discriminatory in pancreatic cancer patients that are not eligible for surgery. In addition, we demonstrate in experimental models that salivary miRNA detection precedes systemic detection of cancer cells markers. This study stems for the use of salivary miRNA as biomarker for the early diagnosis of patients with unresectable pancreatic cancer." -other hsa-mir-23b Pancreatic Neoplasms 26121640 "Our novel findings indicate that salivary miRNA are discriminatory in pancreatic cancer patients that are not eligible for surgery. In addition, we demonstrate in experimental models that salivary miRNA detection precedes systemic detection of cancer cells markers. This study stems for the use of salivary miRNA as biomarker for the early diagnosis of patients with unresectable pancreatic cancer." -other hsa-mir-29c Pancreatic Neoplasms 26121640 "Our novel findings indicate that salivary miRNA are discriminatory in pancreatic cancer patients that are not eligible for surgery. In addition, we demonstrate in experimental models that salivary miRNA detection precedes systemic detection of cancer cells markers. This study stems for the use of salivary miRNA as biomarker for the early diagnosis of patients with unresectable pancreatic cancer." -other hsa-mir-132 Wounds and Injuries [unspecific] 26121747 MicroRNA-132 enhances transition from inflammation to proliferation during wound healing. -other hsa-mir-21 Glioma 26121981 DEAD-box RNA helicase DDX23 modulates glioma malignancy via elevating miR-21 biogenesis. -other hsa-mir-373 Breast Neoplasms 26122224 INFLUENCE OF miR-373 ON THE INVASION AND MIGRATION OF BREAST CANCER AND THE EXPRESSION LEVEL OF TARGET GENES TXNIP. -other hsa-mir-148a Neoplasms [unspecific] 26124099 MicroRNA-148a reduces tumorigenesis and increases TRAIL-induced apoptosis in NSCLC. -other hsa-mir-193a Pleural Mesothelioma 26125439 miR-193a-3p is a potential tumor suppressor in malignant pleural mesothelioma. -other hsa-mir-21 "Carcinoma, Esophageal" 26125864 Association of miR-21 with esophageal cancer prognosis: a meta-analysis. -other hsa-mir-182 "Carcinoma, Hepatocellular" 26126858 Our data showed that hypoxia regulated the expression of miR-182 and RASA1 to promote HCC angiogenesis. -other hsa-mir-125a Breast Neoplasms 26130254 "Relative levels of let-7a, miR-17, miR-27b, miR-125a, miR-125b and miR-206 as potential molecular markers to evaluate grade, receptor status and molecular type in breast cancer." -other hsa-mir-125b Breast Neoplasms 26130254 "Relative levels of let-7a, miR-17, miR-27b, miR-125a, miR-125b and miR-206 as potential molecular markers to evaluate grade, receptor status and molecular type in breast cancer." -other hsa-mir-17 Breast Neoplasms 26130254 "Relative levels of let-7a, miR-17, miR-27b, miR-125a, miR-125b and miR-206 as potential molecular markers to evaluate grade, receptor status and molecular type in breast cancer." -other hsa-mir-206 Breast Neoplasms 26130254 "Relative levels of let-7a, miR-17, miR-27b, miR-125a, miR-125b and miR-206 as potential molecular markers to evaluate grade, receptor status and molecular type in breast cancer." -other hsa-mir-27b Breast Neoplasms 26130254 "Relative levels of let-7a, miR-17, miR-27b, miR-125a, miR-125b and miR-206 as potential molecular markers to evaluate grade, receptor status and molecular type in breast cancer." -other hsa-mir-203 "Carcinoma, Lung" 26132195 miR-203 Inhibits Frizzled-2 Expression via CD82/KAI1 Expression in Human Lung Carcinoma Cells. -other hsa-mir-100 Colorectal Carcinoma 26132860 These findings suggest that extracellular miRNAs can function in target cells and uncover a potential new mode of action for mutant KRAS in CRC. -other hsa-mir-216a Pancreatic Neoplasms 26134156 MicroRNA-216a enhances the radiosensitivity of pancreatic cancer cells by inhibiting beclin-1-mediated autophagy. -other hsa-mir-21 Lung Neoplasms 26134223 A prognostic classifier comprising three types of genomic and epigenomic data may help guide the postoperative management of stage I lung cancer patients at high risk of recurrence. -other hsa-mir-17 Coronary Artery Disease 26134369 MiR-17-5p as circulating biomarkers for the severity of coronary atherosclerosis in coronary artery disease. -other hsa-mir-222 Intervertebral Disc Degeneration 26134418 "a comprehensive microRNA-222 and microRNA-589 gene regulatory network was constructed, which was found to be important in IDD progression." -other hsa-mir-589 Intervertebral Disc Degeneration 26134418 "a comprehensive microRNA-222 and microRNA-589 gene regulatory network was constructed, which was found to be important in IDD progression." -other hsa-mir-204 Glioma 26134825 "Decreased Expression of MiRNA-204-5p Contributes to Glioma Progression and Promotes Glioma Cell Growth, Migration and Invasion." -other hsa-mir-135 Glomerulonephritis 26134897 miR-135 family members mediate podocyte injury through the activation of Wnt/¦Â-catenin signaling. -other hsa-mir-152 "Carcinoma, Nasopharyngeal" 26135619 Our findings provide new insights into the metastasis of NPC regulated by EBV and advocate for developing clinical intervention strategies against NPC. -other hsa-mir-195 "Carcinoma, Nasopharyngeal" 26135619 Our findings provide new insights into the metastasis of NPC regulated by EBV and advocate for developing clinical intervention strategies against NPC. -other hsa-mir-138 Costello Syndrome 26138095 "These results allow us to conclude that the H-Ras G12S mutation plays an important role in miRNA expression and open up a new line of study to understand the consequences of this mutation on Costello syndrome. Furthermore,they suggest that oncogenes may have a sufficiently important impact on miRNA expression to promote the development of numerous cancers." -other hsa-mir-138 Neoplasms [unspecific] 26138095 "These results allow us to conclude that the H-Ras G12S mutation plays an important role in miRNA expression and open up a new line of study to understand the consequences of this mutation on Costello syndrome. Furthermore,they suggest that oncogenes may have a sufficiently important impact on miRNA expression to promote the development of numerous cancers." -other hsa-mir-206 Costello Syndrome 26138095 "These results allow us to conclude that the H-Ras G12S mutation plays an important role in miRNA expression and open up a new line of study to understand the consequences of this mutation on Costello syndrome. Furthermore,they suggest that oncogenes may have a sufficiently important impact on miRNA expression to promote the development of numerous cancers." -other hsa-mir-206 Neoplasms [unspecific] 26138095 "These results allow us to conclude that the H-Ras G12S mutation plays an important role in miRNA expression and open up a new line of study to understand the consequences of this mutation on Costello syndrome. Furthermore,they suggest that oncogenes may have a sufficiently important impact on miRNA expression to promote the development of numerous cancers." -other hsa-mir-330 Costello Syndrome 26138095 "These results allow us to conclude that the H-Ras G12S mutation plays an important role in miRNA expression and open up a new line of study to understand the consequences of this mutation on Costello syndrome. Furthermore,they suggest that oncogenes may have a sufficiently important impact on miRNA expression to promote the development of numerous cancers." -other hsa-mir-330 Neoplasms [unspecific] 26138095 "These results allow us to conclude that the H-Ras G12S mutation plays an important role in miRNA expression and open up a new line of study to understand the consequences of this mutation on Costello syndrome. Furthermore,they suggest that oncogenes may have a sufficiently important impact on miRNA expression to promote the development of numerous cancers." -other hsa-mir-342 Costello Syndrome 26138095 "These results allow us to conclude that the H-Ras G12S mutation plays an important role in miRNA expression and open up a new line of study to understand the consequences of this mutation on Costello syndrome. Furthermore,they suggest that oncogenes may have a sufficiently important impact on miRNA expression to promote the development of numerous cancers." -other hsa-mir-342 Neoplasms [unspecific] 26138095 "These results allow us to conclude that the H-Ras G12S mutation plays an important role in miRNA expression and open up a new line of study to understand the consequences of this mutation on Costello syndrome. Furthermore,they suggest that oncogenes may have a sufficiently important impact on miRNA expression to promote the development of numerous cancers." -other hsa-mir-99b Costello Syndrome 26138095 "These results allow us to conclude that the H-Ras G12S mutation plays an important role in miRNA expression and open up a new line of study to understand the consequences of this mutation on Costello syndrome. Furthermore,they suggest that oncogenes may have a sufficiently important impact on miRNA expression to promote the development of numerous cancers." -other hsa-mir-99b Neoplasms [unspecific] 26138095 "These results allow us to conclude that the H-Ras G12S mutation plays an important role in miRNA expression and open up a new line of study to understand the consequences of this mutation on Costello syndrome. Furthermore,they suggest that oncogenes may have a sufficiently important impact on miRNA expression to promote the development of numerous cancers." -other hsa-mir-31 Psoriasis 26138368 NF-¦ÊB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis. -other hsa-mir-125b Neoplasms [unspecific] 26138442 MAP3K11 might function as an important tumor suppressor neutralized by oncomiR-125b in B-cell leukemia. -other hsa-mir-133 Glioblastoma 26138587 Growth of glioblastoma is inhibited by miR-133-mediated EGFR suppression. -other hsa-mir-449c "Carcinoma, Gastric" 26141986 MiR-449c inhibits gastric carcinoma growth. -other hsa-mir-101 Neoplasms [unspecific] 26145175 MicroRNA-101 Suppresses Tumor Cell Proliferation by Acting as an Endogenous Proteasome Inhibitor via Targeting the Proteasome Assembly Factor POMP. -other hsa-mir-194 Lymphoma 26147452 modulation of microRNA-194 may constitute a novel approach to inhibiting proliferation of EBV(+) B cell lymphomas in PTLD. -other hsa-mir-15a Colorectal Adenoma 26148070 Oncogenic Role of miR-15a-3p in 13q Amplicon-Driven Colorectal Adenoma-to-Carcinoma Progression. -other hsa-mir-125a Obesity 26148871 miR-125a-3p and miR-483-5p promote adipogenesis via suppressing the RhoA/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis. -other hsa-mir-483 Obesity 26148871 miR-125a-3p and miR-483-5p promote adipogenesis via suppressing the RhoA/ROCK1/ERK1/2 pathway in multiple symmetric lipomatosis. -other hsa-mir-150 Influenza 26148929 The up-regulation of miR-150 is associated with poorer outcomes of A/H1N1 infection. The differential expression of miRNAs related with immune processes in severe A/H1N1 disease supports the potential role of these miRNAs as biomarkers of disease progression. -other hsa-mir-107 Glaucoma 26149270 "Experimental evidences indicate that the uveoscleral pathway, via suprachoroidal space, can provide a potential route of access from the anterior region to the posterior segment of the eye and could represent the path followed by biologic mediators to reach the inner layer of the peripapillary retina and transmit damage signals from the anterior to posterior segment during glaucoma course." -other hsa-mir-149 Glaucoma 26149270 "Experimental evidences indicate that the uveoscleral pathway, via suprachoroidal space, can provide a potential route of access from the anterior region to the posterior segment of the eye and could represent the path followed by biologic mediators to reach the inner layer of the peripapillary retina and transmit damage signals from the anterior to posterior segment during glaucoma course." -other hsa-mir-21 Glaucoma 26149270 "Experimental evidences indicate that the uveoscleral pathway, via suprachoroidal space, can provide a potential route of access from the anterior region to the posterior segment of the eye and could represent the path followed by biologic mediators to reach the inner layer of the peripapillary retina and transmit damage signals from the anterior to posterior segment during glaucoma course." -other hsa-mir-450 Glaucoma 26149270 "Experimental evidences indicate that the uveoscleral pathway, via suprachoroidal space, can provide a potential route of access from the anterior region to the posterior segment of the eye and could represent the path followed by biologic mediators to reach the inner layer of the peripapillary retina and transmit damage signals from the anterior to posterior segment during glaucoma course." -other hsa-mir-21 Lymphoma 26150475 Expression and clinicopathological significance of microRNA-21 and programmed cell death 4 in malignant melanoma. -other hsa-mir-1181 Ovarian Neoplasms 26151663 Activation of ARK5/miR-1181/HOXA10 axis promotes epithelial-mesenchymal transition in ovarian cancer. -other hsa-mir-133a Rhabdomyosarcoma 26153023 "ARS treatment in ERMS cells ROS-dependently induces the expression of the myo-miRs, miR-133a and miR-206, which are down-regulated in RMS, and reduces PAX7 protein levels." -other hsa-mir-126 Lung Neoplasms 26156018 most analyzed miRNA genes undergo substantial copy number alteration in lung cancer. -other hsa-mir-155 Lung Neoplasms 26156018 most analyzed miRNA genes undergo substantial copy number alteration in lung cancer. -other hsa-mir-17 Lung Neoplasms 26156018 most analyzed miRNA genes undergo substantial copy number alteration in lung cancer. -other hsa-mir-205 Lung Neoplasms 26156018 most analyzed miRNA genes undergo substantial copy number alteration in lung cancer. -other hsa-mir-21 Lung Neoplasms 26156018 "The most frequently amplified miRNA genes include the following: miR-30d, miR-21, miR-17 and miR-155." -other hsa-mir-30a Lung Neoplasms 26156018 "The most frequently amplified miRNA genes include the following: miR-30d, miR-21, miR-17 and miR-155." -other hsa-mir-30d Lung Neoplasms 26156018 "The most frequently amplified miRNA genes include the following: miR-30d, miR-21, miR-17 and miR-155." -other hsa-mir-31 Lung Neoplasms 26156018 most analyzed miRNA genes undergo substantial copy number alteration in lung cancer. -other hsa-mir-92 Lung Neoplasms 26156018 most analyzed miRNA genes undergo substantial copy number alteration in lung cancer. -other hsa-mir-21 Neoplasms [unspecific] 26156753 "This is the first study to demonstrate that kallistatin's heparin-binding site is crucial for preventing TGF-¦Â-induced miR-21 and oxidative stress, while its active site is key for stimulating the expression of antioxidant genes via interaction with an endothelial surface tyrosine kinase.These findings reveal novel mechanisms of kallistatin in protection against fibrosis and cancer by suppressing EndMT." -other hsa-mir-145 "Carcinoma, Esophageal" 26156802 The effect of recombinant lentiviral vector encoding miR-145 on human esophageal cancer cells. -other hsa-mir-146a "Squamous Cell Carcinoma, Oral" 26159827 Decrease of miR-146a is associated with the aggressiveness of human oral squamous cell carcinoma. -other hsa-mir-23a Osteosarcoma 26160225 MicroRNA-23a enhances migration and invasion through PTEN in osteosarcoma. -other hsa-mir-323 Prostate Neoplasms 26160610 Our data demonstrate that miR-323 may increase VEGF-A-mediated cancer vascularization in PC cells through AdipoR1 suppression. -other hsa-mir-451a Breast Neoplasms 26161389 miR-451a Inhibited Cell Proliferation and Enhanced Tamoxifen Sensitive in Breast Cancer via Macrophage Migration Inhibitory Factor. -other hsa-let-7b Influenza 26163223 These results indicate that the influenza virus containing microRNA response elements (MREs) is attenuated in vivo and can be used to design a live attenuated vaccine. -other hsa-mir-502 "Carcinoma, Hepatocellular" 26163264 miR-502 inhibits cell proliferation and tumor growth in hepatocellular carcinoma through suppressing phosphoinositide 3-kinase catalytic subunit gamma. -other hsa-mir-376c Prostate Neoplasms 26163549 Regulation of Human UGT2B15 and UGT2B17 by miR-376c in Prostate Cancer Cell Lines. -other hsa-mir-223 "Leukemia, Myeloid, Acute" 26163797 MicroRNA-223 dose levels fine tune proliferation and differentiation in human cord blood progenitors and acute myeloid leukemia. -other hsa-mir-141 Breast Neoplasms 26164002 miR-141 as potential suppressor of ¦Â-catenin in breast cancer. -other hsa-mir-451 "Carcinoma, Hepatocellular" 26164082 MicroRNA-451: epithelial-mesenchymal transition inhibitor and prognostic biomarker of hepatocelluar carcinoma. -other hsa-mir-31 Glioblastoma 26164206 Loss of tumor suppressive microRNA-31 enhances TRADD/NF-¦ÊB signaling in glioblastoma. -other hsa-mir-221 Prostate Neoplasms 26164758 Effects of microRNA-221/222 on cell proliferation and apoptosis in prostate cancer cells. -other hsa-mir-222 Prostate Neoplasms 26164758 Effects of microRNA-221/222 on cell proliferation and apoptosis in prostate cancer cells. -other hsa-mir-146 Cardiometabolic Disorders 26165231 Post-Transcriptional Regulation of Renalase Gene by miR-29 and miR-146 MicroRNAs:Implications for Cardiometabolic Disorders. -other hsa-mir-29 Cardiometabolic Disorders 26165231 Post-Transcriptional Regulation of Renalase Gene by miR-29 and miR-146 MicroRNAs:Implications for Cardiometabolic Disorders. -other hsa-mir-139 "Leukemia, Myeloid" 26165837 miR-139-5p controls translation in myeloid leukemia through EIF4G2. -other hsa-mir-15b Pancreatic Neoplasms 26166038 miR-15b promotes epithelial-mesenchymal transition by inhibiting SMURF2 in pancreatic cancer. -other hsa-mir-324 Breast Neoplasms 26166821 Sinomenine inhibits breast cancer cell invasion and migration by suppressing NF-¦ÊB activation mediated by IL-4/miR-324-5p/CUEDC2 axis. -other hsa-mir-21 Ischemia-Reperfusion Injury 26168042 "losartan treatment significantly increased microRNA (miR)-1, -15b, -92a, -133a, -133b, -210, and -499 expression but decreased miR-21 in the left ventricle." -other hsa-mir-21 Myocardial Infarction 26168042 "losartan treatment significantly increased microRNA (miR)-1, -15b, -92a, -133a, -133b, -210, and -499 expression but decreased miR-21 in the left ventricle." -other hsa-mir-145 Neoplasms [unspecific] 26168819 "Treatments of T-CIN+ cells with senescence-conditioned media induce sphere formation exclusively in cells with senescence-associated tumorigenicity, a capacity that depends on miR-145 repression." -other hsa-mir-125b Glioma 26170223 PI3K inhibitor combined with miR-125b inhibitor sensitize TMZ-induced anti-glioma stem cancer effects through inactivation of Wnt/¦Â-catenin signaling pathway. -other hsa-mir-183 Non-Sensory Diseases 26170234 the genomic organization and seeming redundancy of the miR-183 family cluster was conserved through 600 million years of evolution -other hsa-mir-150 Neoplasms [unspecific] 26170969 iR-150 may be a potential biomarker and therapeutic target in the diagnosis and treatment of various malignancies. -other hsa-mir-27a Sepsis 26171875 "RhTNFR:Fc improved cardiac function of sepsis mice, and markedly decreased miR-27a but increased Nrf2 expression level of myocardium in LPS treated mice." -other hsa-mir-375 "Squamous Cell Carcinoma, Head and Neck" 26172508 MicroRNA-375 Suppresses Extracellular Matrix Degradation and Invadopodial Activity in Head and Neck Squamous Cell Carcinoma. -other hsa-mir-31 Early-Stage Colon Carcinoma 26173758 The potential role of microRNA-31 expression in early colorectal cancer. -other hsa-mir-1246 Hemophilia A 26176629 Small ncRNA Expression-Profiling of Blood from Hemophilia A Patients Identifies miR-1246 as a Potential Regulator of Factor 8 Gene. -other hsa-mir-30a Atherosclerosis 26176854 "we here report the successful use of miRNA technology to silence a platelet protein in megakaryoblastic cells and demonstrate its usefulness in functional assays. Hence, we believe that artificial miRNAs are suitable tools to unravel the role of a protein of interest in stem cells, megakaryocytes and platelets, thereby expanding their application to novel fields of basic and translational research." -other hsa-mir-155 Melanoma 26176991 "hsa-mir-214-3p, hsa-miR-199a-3p,hsa-miR-155-5p in subsets of EVs released by melanoma cells, with significant similarities to clinical melanoma tissue, and provides unique insights into the contribution of EV associated extracellular RNA in cancer." -other hsa-mir-199a Melanoma 26176991 "hsa-mir-214-3p, hsa-miR-199a-3p,hsa-miR-155-5p in subsets of EVs released by melanoma cells, with significant similarities to clinical melanoma tissue, and provides unique insights into the contribution of EV associated extracellular RNA in cancer." -other hsa-mir-214 Melanoma 26176991 "hsa-mir-214-3p, hsa-miR-199a-3p,hsa-miR-155-5p in subsets of EVs released by melanoma cells, with significant similarities to clinical melanoma tissue, and provides unique insights into the contribution of EV associated extracellular RNA in cancer." -other hsa-mir-135b Colorectal Carcinoma 26178670 miR-135b and miR-146b-dependent silencing of calcium-sensing receptor expression in colorectal tumors. -other hsa-mir-146b Colorectal Carcinoma 26178670 miR-135b and miR-146b-dependent silencing of calcium-sensing receptor expression in colorectal tumors. -other hsa-mir-27a Colorectal Carcinoma 26178670 miR-135b and miR-146b-dependent silencing of calcium-sensing receptor expression in colorectal tumors. -other hsa-mir-9 Colorectal Carcinoma 26178670 miR-135b and miR-146b-dependent silencing of calcium-sensing receptor expression in colorectal tumors. -other hsa-let-7 Breast Neoplasms 26178901 "The most abundant exosome microRNAs (let-7a, miR-23b, miR-27a/b, miR-21, let-7, and miR-320b) are known to have anti-cancer and/or anti-angiogenic activity." -other hsa-let-7a Breast Neoplasms 26178901 "The most abundant exosome microRNAs (let-7a, miR-23b, miR-27a/b, miR-21, let-7, and miR-320b) are known to have anti-cancer and/or anti-angiogenic activity." -other hsa-mir-21 Breast Neoplasms 26178901 "The most abundant exosome microRNAs (let-7a, miR-23b, miR-27a/b, miR-21, let-7, and miR-320b) are known to have anti-cancer and/or anti-angiogenic activity." -other hsa-mir-23b Breast Neoplasms 26178901 "The most abundant exosome microRNAs (let-7a, miR-23b, miR-27a/b, miR-21, let-7, and miR-320b) are known to have anti-cancer and/or anti-angiogenic activity." -other hsa-mir-27a Breast Neoplasms 26178901 "The most abundant exosome microRNAs (let-7a, miR-23b, miR-27a/b, miR-21, let-7, and miR-320b) are known to have anti-cancer and/or anti-angiogenic activity." -other hsa-mir-27b Breast Neoplasms 26178901 "The most abundant exosome microRNAs (let-7a, miR-23b, miR-27a/b, miR-21, let-7, and miR-320b) are known to have anti-cancer and/or anti-angiogenic activity." -other hsa-mir-320b Breast Neoplasms 26178901 "The most abundant exosome microRNAs (let-7a, miR-23b, miR-27a/b, miR-21, let-7, and miR-320b) are known to have anti-cancer and/or anti-angiogenic activity." -other hsa-mir-141 Colorectal Carcinoma 26179333 Effects of Decitabine on Invasion and Exosomal Expression of miR-200c and miR-141 in Oxaliplatin-Resistant Colorectal Cancer Cells. -other hsa-mir-200c Colorectal Carcinoma 26179333 Effects of Decitabine on Invasion and Exosomal Expression of miR-200c and miR-141 in Oxaliplatin-Resistant Colorectal Cancer Cells. -other hsa-mir-122 "Carcinoma, Hepatocellular" 26179591 Single-Vehicular Delivery of Antagomir and Small Molecules to Inhibit miR-122 Function in Hepatocellular Carcinoma Cells by using Smart Mesoporous Silica Nanoparticles. -other hsa-mir-125b Human Papilloma Virus Infection 26180794 miR-34a and miR-125b Expression in HPV Infection and Cervical Cancer Development. -other hsa-mir-34a Human Papilloma Virus Infection 26180794 miR-34a and miR-125b Expression in HPV Infection and Cervical Cancer Development. -other hsa-mir-155 Human Immunodeficiency Virus Infection 26181817 Levels of miR-155 and miR-223 but not miR-92 were strongly correlated negatively with EV abundance and size in ART-naive patients. -other hsa-mir-223 Human Immunodeficiency Virus Infection 26181817 Levels of miR-155 and miR-223 but not miR-92 were strongly correlated negatively with EV abundance and size in ART-naive patients. -other hsa-mir-373 "Adenocarcinoma, Lung" 26182868 MiR-373-3p Promotes Invasion and Metastasis of Lung Adenocarcinoma Cells -other hsa-mir-3178 "Carcinoma, Hepatocellular" 26182877 Regulation of tumorigenesis and metastasis of hepatocellular carcinoma tumor endothelial cells by microRNA-3178 and underlying mechanism. -other hsa-mir-326 Glioma 26183397 Knockdown of long non-coding RNA HOTAIR inhibits malignant biological behaviors of human glioma cells via modulation of miR-326. -other hsa-mir-205 Colorectal Carcinoma 26183718 the integration of multiple omics methods allowed the comprehensive identification of direct and indirect effectors of p53 that provide new insights and leads into the mechanisms of p53-mediated tumor suppression. -other hsa-mir-34a Colorectal Carcinoma 26183718 the integration of multiple omics methods allowed the comprehensive identification of direct and indirect effectors of p53 that provide new insights and leads into the mechanisms of p53-mediated tumor suppression. -other hsa-mir-486 Colorectal Carcinoma 26183718 the integration of multiple omics methods allowed the comprehensive identification of direct and indirect effectors of p53 that provide new insights and leads into the mechanisms of p53-mediated tumor suppression. -other hsa-mir-142 "Carcinoma, Nasopharyngeal" 26183850 MiR-142-3p Suppresses SOCS6 Expression and Promotes Cell Proliferation in Nasopharyngeal Carcinoma. -other hsa-mir-21 Colorectal Carcinoma 26184038 IL6 Mediates Immune and Colorectal Cancer Cell Cross-talk via miR-21 and miR-29b. -other hsa-mir-29b Colorectal Carcinoma 26184038 IL6 Mediates Immune and Colorectal Cancer Cell Cross-talk via miR-21 and miR-29b. -other hsa-mir-33 Mitochondrial Metabolism Disease 26185207 Novel Role of miR-33 in Regulating of Mitochondrial Function. -other hsa-mir-206 Gastric Neoplasms 26186594 MicroRNA-206: Effective Inhibition of Gastric Cancer Progression through the c-Met Pathway. -other hsa-let-7 Neoplasms [unspecific] 26187994 "Our data reveal an unexpected role of Rho-associated, coiled-coil-containing protein kinase (ROCK1) as a cofactor of HNF4A in enhancing PAIP2 transcription. Rho-associated, coiled-coil-containing protein kinase (ROCK) inhibitors may be useful for the various pathologies associated with the impairment of global miRNA function." -other hsa-mir-122 Neoplasms [unspecific] 26187994 "Our data reveal an unexpected role of Rho-associated, coiled-coil-containing protein kinase (ROCK1) as a cofactor of HNF4A in enhancing PAIP2 transcription. Rho-associated, coiled-coil-containing protein kinase (ROCK) inhibitors may be useful for the various pathologies associated with the impairment of global miRNA function." -other hsa-mir-124 "Carcinoma, Hepatocellular" 26188282 PABPC1 interacts with AGO2 and is responsible for the microRNA mediated gene silencing in high grade hepatocellular carcinoma. -other hsa-mir-183 "Carcinoma, Hepatocellular" 26188282 PABPC1 interacts with AGO2 and is responsible for the microRNA mediated gene silencing in high grade hepatocellular carcinoma. -other hsa-mir-26a Pancreatic Neoplasms 26189069 Enhanced phosphorylation of p53 by microRNA-26a leading to growth inhibition of pancreatic cancer. -other hsa-mir-21 Neoplasms [unspecific] 26189797 RNA-binding protein HuR sequesters microRNA-21 to prevent translation repression of proinflammatory tumor suppressor gene programmed cell death 4. -other hsa-mir-155 Helicobacter pylori Infection 26191144 Inflammatory response of macrophages cultured with Helicobacter pylori strains was regulated by miR-155. -other hsa-mir-21 "Squamous Cell Carcinoma, Tongue" 26191145 The role of miR-21 in proliferation and invasion capacity of human tongue squamous cell carcinoma in vitro. -other hsa-mir-302a Ovarian Neoplasms 26191180 MiR-302a inhibits the tumorigenicity of ovarian cancer cells by suppression of SDC1. -other hsa-mir-188 Rheumatoid Arthritis 26191188 Expression and function of microRNA-188-5p in activated rheumatoid arthritis synovial fibroblasts. -other hsa-mir-34 Chronic Obstructive Pulmonary Disease 26191210 These proofs suggest that resveratrol inhibited dysfunction of dendritic cells (DCs) from COPD patients through promoting miR-34. -other hsa-mir-21 Neoplasms [unspecific] 26191606 The activated single-stranded DC can project the LAA headgroup into the hCA-II active site and is a robust hCA-II inhibitor (K(i) of 3.12 ¦ÌM). This work may spur research into developing new classes of cancer selective protein inhibitors. -other hsa-mir-155 Pancreatic Neoplasms 26195069 Pancreatic cancer-secreted miR-155 implicates in the conversion from normal fibroblasts to cancer-associated fibroblasts. -other hsa-mir-122 Growth Disorders 26198739 "Why is microRNA action tissue specific. A putative defense mechanism against growth disorders, tumor development or progression mediated by circulating microRNA" -other hsa-mir-15 Growth Disorders 26198739 "Why is microRNA action tissue specific. A putative defense mechanism against growth disorders, tumor development or progression mediated by circulating microRNA" -other hsa-mir-16 Growth Disorders 26198739 "Why is microRNA action tissue specific. A putative defense mechanism against growth disorders, tumor development or progression mediated by circulating microRNA" -other hsa-mir-21 Growth Disorders 26198739 "Why is microRNA action tissue specific. A putative defense mechanism against growth disorders, tumor development or progression mediated by circulating microRNA" -other hsa-mir-503 Growth Disorders 26198739 "Why is microRNA action tissue specific. A putative defense mechanism against growth disorders, tumor development or progression mediated by circulating microRNA" -other hsa-mir-221 "Carcinoma, Renal Cell" 26201448 Gain of function experiments showed that miR-221 and miR-222 decreased angiogenesis and cellular proliferation in human umbilical vein endothelial cells (HUVEC) while increasing cellular proliferation in ACHN cells. miRNAs represent potential predictive markers for sunitinib response. -other hsa-mir-222 "Carcinoma, Renal Cell" 26201448 Gain of function experiments showed that miR-221 and miR-222 decreased angiogenesis and cellular proliferation in human umbilical vein endothelial cells (HUVEC) while increasing cellular proliferation in ACHN cells. miRNAs represent potential predictive markers for sunitinib response. -other hsa-mir-573 "Carcinoma, Hepatocellular" 26201458 The miR-573/apoM/Bcl2A1-dependent signal transduction pathway is essential for hepatocyte apoptosis and hepatocarcinogenesis. -other hsa-mir-223 Pulmonary Hypertension 26201953 MicroRNAs and PARP: co-conspirators with ROS in pulmonary hypertension. Focus on miR-223 reverses experimental pulmonary arterial hypertension. -other hsa-mir-497 Osteosarcoma 26202364 "Taken together, our results suggest that miR-497 modulates the sensitivity to cisplatin at least in part through PI3K/Akt pathway in osteosarcoma cells." -other hsa-let-7a Digeorge Syndrome 26202964 "Collectively, our data suggest a novel mechanism that SUMOylation of DGCR8 controls direct functions of pri-miRNAs in gene silencing." -other hsa-mir-125b Aortic Insufficiency 26203686 MicroRNA-125b and chemokine CCL4 expression are associated with calcific aortic valve disease. -other hsa-mir-221 Viral Myocarditis 26206211 "The miR-221/-222 cluster orchestrates the antiviral and inflammatory immune response to viral infection of the heart. Its inhibition increases viral load, inflammation, and overall cardiac injury upon VM." -other hsa-mir-222 Viral Myocarditis 26206211 "The miR-221/-222 cluster orchestrates the antiviral and inflammatory immune response to viral infection of the heart. Its inhibition increases viral load, inflammation, and overall cardiac injury upon VM." -other hsa-mir-9 "Carcinoma, Hepatocellular" 26206264 this study revealed the involvement of the miR-9/PPARA/CDH1 signaling pathway in HCC oncogenesis. -other hsa-mir-100 Inflammation 26209130 Such delicately counterbalanced systems are a hallmark of immune plasticity and we propose that miR-100 editing is a novel mechanism toward this end. -other hsa-let-7a "Carcinoma, Cervical" 26209160 The effects of lanthanum chloride on proliferation and apoptosis of cervical cancer cells: involvement of let-7a and miR-34a microRNAs. -other hsa-mir-34a "Carcinoma, Cervical" 26209160 The effects of lanthanum chloride on proliferation and apoptosis of cervical cancer cells: involvement of let-7a and miR-34a microRNAs. -other hsa-mir-3651 "Squamous Cell Carcinoma, Esophageal" 26210449 Clinical potential of miR-3651 as a novel prognostic biomarker for esophageal squamous cell cancer. -other hsa-mir-203a "Carcinoma, Hepatocellular" 26210453 Downregulation of miRNA-30c and miR-204a is associated with hepatitis C virus core protein-induced epithelial-mesenchymal transition in normal hepatocytes and hepatocellular carcinoma cells. -other hsa-mir-30c "Carcinoma, Hepatocellular" 26210453 Downregulation of miRNA-30c and miR-203a is associated with hepatitis C virus core protein-induced epithelial-mesenchymal transition in normal hepatocytes and hepatocellular carcinoma cells. -other hsa-mir-146a Gastrointestinal Neoplasms 26211779 miR-146a cancer susceptibility gene polymorphism is closely associated with gastrointestinal cancers. -other hsa-mir-200 "Carcinoma, Ovarian" 26213923 The miR-200 Family: Versatile Players in Epithelial Ovarian Cancer. -other hsa-mir-17 Colorectal Carcinoma 26215320 Calycosin induces apoptosis by the regulation of ER¦Â/miR-17 signaling pathway in human colorectal cancer cells. -other hsa-mir-431 Muscle Diseases [unspecific] 26215566 our results suggest that the age-associated miR-431 plays a key role in maintaining the myogenic ability of skeletal muscle with age. -other hsa-mir-137 Breast Neoplasms 26215676 A contrasting function for miR-137 in embryonic mammogenesis and adult breast carcinogenesis. -other hsa-mir-150 "Carcinoma, Hepatocellular" 26215970 microRNA-150: a promising novel biomarker for hepatitis B virus-related hepatocellular carcinoma. -other hsa-mir-153 Lung Fibrosis 26216407 "These data suggest that miR-153 disturbs TGF-¦Â1 signal transduction and its effects on fibroblast activation, acting as an anti-fibrotic element in the development of pulmonary fibrosis." -other hsa-mir-375 Hypogonadism 26219823 "we identified miR-375 as an androgen regulated microRNA, which could play an important role for understanding the mechanism of the increase in visceral fat mass and the associated insulin resistance caused by testosterone deficiency." -other hsa-mir-21 Neoplasms [unspecific] 26220158 "preliminary mechanism of action studies propose a different mode of action compared to previously reported miR-21 inhibitors, thus affording a new chemical probe for future studies." -other hsa-mir-1 Atrial Fibrillation 26221584 The results suggest that immediate-early miRNA remodeling coupled with deregulation of TF expression underlies the onset of AF. -other hsa-mir-10a Atrial Fibrillation 26221584 The results suggest that immediate-early miRNA remodeling coupled with deregulation of TF expression underlies the onset of AF. -other hsa-mir-10b Atrial Fibrillation 26221584 The results suggest that immediate-early miRNA remodeling coupled with deregulation of TF expression underlies the onset of AF. -other hsa-mir-21 Atrial Fibrillation 26221584 The results suggest that immediate-early miRNA remodeling coupled with deregulation of TF expression underlies the onset of AF. -other hsa-mir-221 Atherosclerosis 26221589 Human miR-221/222 in Physiological and Atherosclerotic Vascular Remodeling. -other hsa-mir-222 Atherosclerosis 26221589 Human miR-221/222 in Physiological and Atherosclerotic Vascular Remodeling. -other hsa-mir-330 "Adenocarcinoma, Esophageal" 26221725 MicroRNA-330-5p as a Putative Modulator of Neoadjuvant Chemoradiotherapy Sensitivity in Oesophageal Adenocarcinoma. -other hsa-mir-106a "Carcinoma, Colon" 26224446 Long non-coding RNA Fer-1-like protein 4 suppresses oncogenesis and exhibits prognostic value by associating with miR-106a-5p in colon cancer. -other hsa-mir-124 "Squamous Cell Carcinoma, Head and Neck" 26227488 miR-124 Regulates the Epithelial-Restricted with Serine Box/Epidermal Growth Factor Receptor Signaling Axis in Head and Neck Squamous Cell Carcinoma. -other hsa-mir-34a Prostate Neoplasms 26231042 Registered report: the microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. -other hsa-mir-17 "Carcinoma, Hepatocellular" 26231474 MiR-17-95 cluster promotes hepatocarcinogenesis. -other hsa-mir-18 "Carcinoma, Hepatocellular" 26231474 MiR-17-95 cluster promotes hepatocarcinogenesis. -other hsa-mir-19a "Carcinoma, Hepatocellular" 26231474 MiR-17-95 cluster promotes hepatocarcinogenesis. -other hsa-mir-19b-1 "Carcinoma, Hepatocellular" 26231474 MiR-17-95 cluster promotes hepatocarcinogenesis. -other hsa-mir-20a "Carcinoma, Hepatocellular" 26231474 MiR-17-95 cluster promotes hepatocarcinogenesis. -other hsa-mir-92-1 "Carcinoma, Hepatocellular" 26231474 MiR-17-95 cluster promotes hepatocarcinogenesis. -other hsa-mir-4295 Thyroid Neoplasms 26231799 miR-4295 promotes cell proliferation and invasion in anaplastic thyroid carcinoma via CDKN1A. -other hsa-mir-17 "Carcinoma, Hepatocellular" 26232302 MiR-17-94 cluster promotes hepatocarcinogenesis. -other hsa-mir-18 "Carcinoma, Hepatocellular" 26232302 MiR-17-94 cluster promotes hepatocarcinogenesis. -other hsa-mir-19a "Carcinoma, Hepatocellular" 26232302 MiR-17-94 cluster promotes hepatocarcinogenesis. -other hsa-mir-19b-1 "Carcinoma, Hepatocellular" 26232302 MiR-17-94 cluster promotes hepatocarcinogenesis. -other hsa-mir-20a "Carcinoma, Hepatocellular" 26232302 MiR-17-94 cluster promotes hepatocarcinogenesis. -other hsa-mir-92-1 "Carcinoma, Hepatocellular" 26232302 MiR-17-94 cluster promotes hepatocarcinogenesis. -other hsa-mir-17 "Carcinoma, Hepatocellular" 26233130 MiR-17-93 cluster promotes hepatocarcinogenesis. -other hsa-mir-18 "Carcinoma, Hepatocellular" 26233130 MiR-17-93 cluster promotes hepatocarcinogenesis. -other hsa-mir-19a "Carcinoma, Hepatocellular" 26233130 MiR-17-93 cluster promotes hepatocarcinogenesis. -other hsa-mir-19b-1 "Carcinoma, Hepatocellular" 26233130 MiR-17-93 cluster promotes hepatocarcinogenesis. -other hsa-mir-20a "Carcinoma, Hepatocellular" 26233130 MiR-17-93 cluster promotes hepatocarcinogenesis. -other hsa-mir-92-1 "Carcinoma, Hepatocellular" 26233130 MiR-17-93 cluster promotes hepatocarcinogenesis. -other hsa-mir-106b Colorectal Carcinoma 26238857 MiR-106b induces cell radioresistance via the PTEN/PI3K/AKT pathways and p21 in colorectal cancer. -other hsa-mir-19a "Carcinoma, Gastric" 26239140 MicroRNA-19a mediates gastric carcinoma cell proliferation through the activation of nuclear factor-¦ÊB. -other hsa-mir-146a Glioblastoma 26239619 Induction of microRNA-146a is involved in curcumin-mediated enhancement of temozolomide cytotoxicity against human glioblastoma. -other hsa-mir-122 Osteoarthritis 26239639 An insertion/deletion polymorphism at the microRNA-122 binding site in the interleukin-1¦Á 3'-untranslated region is associated with a risk for osteoarthritis. -other hsa-let-7f Asthma 26242299 "17¦Â-E2+P4 increased IL-17A production from TH17 cells, providing a potential mechanism for the increased prevalence of severe asthma in women compared with men." -other hsa-mir-21 Meningioma 26242334 "Increased miR-21 and nestin mRNA levels were found in anaplastic meningiomas, in which recurrence is common, and the role of miR-21 and Nestin in meningiomas therefore warrants further investigation." -other hsa-mir-335 Osteoarthritis 26243143 Signature of microRNA expression during osteogenic differentiation of bone marrow MSCs reveals a putative role of miR-335-5p in osteoarthritis. -other hsa-mir-126 Thyroid Neoplasms 26244545 "To our knowledge, this is the first study to demonstrate that miR-126-3p has a tumor-suppressive function in thyroid cancer cells, and is associated with aggressive disease phenotype." -other hsa-mir-367 Medulloblastoma 26250335 miR-367 promotes proliferation and stem-like traits in medulloblastoma cells. -other hsa-mir-29a "Leukemia, Lymphoblastic, Acute" 26251039 Potential roles of microRNA-29a in the molecular pathophysiology of T-cell acute lymphoblastic leukemia. -other hsa-mir-199a Lymphoma 26251897 miR-199a and miR-497 Are Associated with Better Overall Survival due to Increased Chemosensitivity in Diffuse Large B-Cell Lymphoma Patients. -other hsa-mir-497 Lymphoma 26251897 miR-199a and miR-497 Are Associated with Better Overall Survival due to Increased Chemosensitivity in Diffuse Large B-Cell Lymphoma Patients. -other hsa-mir-144 Breast Neoplasms 26252024 "MicroRNA-144 affects radiotherapy sensitivity by promoting proliferation,migration and invasion of breast cancer cells." -other hsa-mir-374a "Carcinoma, Esophageal" 26252180 MicroRNA-374a promotes esophageal cancer cell proliferation via Axin2 suppression. -other hsa-mir-143 "Squamous Cell Carcinoma, Cerevial" 26252302 A Functional Polymorphism in the Promoter of MiR-143/145 Is Associated With the Risk of Cervical Squamous Cell Carcinoma in Chinese Women: A Case-Control Study. -other hsa-mir-145 "Squamous Cell Carcinoma, Cerevial" 26252302 A Functional Polymorphism in the Promoter of MiR-143/145 Is Associated With the Risk of Cervical Squamous Cell Carcinoma in Chinese Women: A Case-Control Study. -other hsa-mir-24 Respiratory Syncytial Virus Pneumonia 26253191 Human respiratory syncytial virus non-structural protein NS1 modifies miR-24 expression via transforming growth factor-¦Â. -other hsa-mir-148a "Squamous Cell Carcinoma, Skin or Unspecific" 26253263 Role of miR-148a in cutaneous squamous cell carcinoma by repression of MAPK pathway. -other hsa-mir-30a Glioma 26255203 MiR-30a-5p is induced by Wnt/¦Â-catenin pathway and promotes glioma cell invasion by repressing NCAM. -other hsa-mir-100 "Carcinoma, Rectal" 26255374 "The proposed methodology effectively made use of literature data and was able to show novel,significant miRNA-transcription associations in CRC." -other hsa-mir-630 "Carcinoma, Rectal" 26255374 "The proposed methodology effectively made use of literature data and was able to show novel,significant miRNA-transcription associations in CRC." -other hsa-mir-99a "Carcinoma, Rectal" 26255374 "The proposed methodology effectively made use of literature data and was able to show novel,significant miRNA-transcription associations in CRC." -other hsa-mir-17 Neoplasms [unspecific] 26255770 developmentally regulated pro-miRNA processing is a key step controlling miRNA expression and explains the posttranscriptional control of miR-17-92 expression in development. -other hsa-mir-451 Neoplasms [unspecific] 26257001 "Both, energy-conserving metabolic shift and resource-seeking behavioral change require brain tumor cell to shut down miR-451, while forced expression of miR-451 during stress leads to cytotoxicity [3]. The AMPK-dependent inactivation of the OCT1 transcriptional activator of miR-451 helps brain tumor cells to escape from metabolically stressful events/locations. MiR-451 thus provides an example of a molecule that is not deregulated in brain tumor cells, but is instead finely regulated by promoting or suppressing brain tumor cell phenotypes based on microenvironmental contexts." -other hsa-let-7i "Squamous Cell Carcinoma, Head and Neck" 26257063 IB suppresses EMT and stemness of HNSCC cells through inhibition of Twist1-mediated let-7i downregulation and Rac1 activation and the EMT signalling. -other hsa-mir-128 Neuroblastoma 26258008 Such miRNAs regulate genes involved in cellular processes -other hsa-mir-130a Neuroblastoma 26258008 Such miRNAs regulate genes involved in cellular processes -other hsa-mir-181a Neuroblastoma 26258008 Such miRNAs regulate genes involved in cellular processes -other hsa-mir-18a Neuroblastoma 26258008 Such miRNAs regulate genes involved in cellular processes -other hsa-mir-21 Neuroblastoma 26258008 Such miRNAs regulate genes involved in cellular processes -other hsa-mir-218 Neuroblastoma 26258008 Such miRNAs regulate genes involved in cellular processes -other hsa-mir-380 Neuroblastoma 26258008 Such miRNAs regulate genes involved in cellular processes -other hsa-mir-424 Neuroblastoma 26258008 Such miRNAs regulate genes involved in cellular processes -other hsa-mir-451 Neuroblastoma 26258008 Such miRNAs regulate genes involved in cellular processes -other hsa-mir-558 Neuroblastoma 26258008 Such miRNAs regulate genes involved in cellular processes -other hsa-mir-7 Neuroblastoma 26258008 Such miRNAs regulate genes involved in cellular processes -other hsa-mir-373 Breast Neoplasms 26258411 Epigenetic silencing of ITGA2 by MiR-373 promotes cell migration in breast cancer. -other hsa-mir-21 Ischemia-Reperfusion Injury 26259139 Isoflurane protects mouse hearts from ischemia-reperfusion injury by a microRNA-21-dependent mechanism. -other hsa-mir-15a Neoplasms [unspecific] 26260813 miRNA-15a/16: as tumor suppressors and more. -other hsa-mir-16 Neoplasms [unspecific] 26260813 miRNA-15a/16: as tumor suppressors and more. -other hsa-mir-127 Glioma 26261488 Knockdown of microRNA-127 reverses adriamycin resistance via cell cycle arrest and apoptosis sensitization in adriamycin-resistant human glioma cells. -other hsa-mir-1908 Glioblastoma 26265437 miRNA-1908 functions as an oncogene in glioblastoma by repressing the PTEN pathway. MiR-1908 is a potential new molecular marker for predicting the risk of recurrence and prognosis of glioblastoma. -other hsa-mir-21 Gastric Neoplasms 26265521 MicroRNA-21: Mechanisms of Oncogenesis and its Application in Diagnosis and Prognosis of Gastric Cancer. -other hsa-mir-124 Glioma 26269187 Our findings indicate a clear benefit in harnessing the wild-type virus replicative potency in development of next-generation oncolytic alphaviruses. -other hsa-mir-21 Breast Neoplasms 26270351 Breast Cancer/Stromal Cells Coculture on Polyelectrolyte Films Emulates Tumor Stages and miRNA Profiles of Clinical Samples. -other hsa-mir-21 Neoplasms [unspecific] 26271820 MicroRNA-Responsive Cancer Cell Imaging and Therapy with Functionalized Gold Nanoprobe. -other hsa-mir-429 Glioma 26272601 Our results indicated that BMK1 modulation by miR-429 has an important function in glioma invasion both in vitro and in vivo. -other hsa-let-7 Muscular Dystrophy 26272747 Our study therefore introduces additional biological players in the regulation of skeletal muscle structure and myogenesis that may contribute to unexplained disorders of MD. -other hsa-let-7e Muscular Dystrophy 26272747 Our study therefore introduces additional biological players in the regulation of skeletal muscle structure and myogenesis that may contribute to unexplained disorders of MD. -other hsa-mir-98 Muscular Dystrophy 26272747 Our study therefore introduces additional biological players in the regulation of skeletal muscle structure and myogenesis that may contribute to unexplained disorders of MD. -other hsa-mir-150 Autoimmune Diseases [unspecific] 26275076 dysregulated expression of miR-150 in immune cells might result in autoimmune diseases. -other hsa-mir-1 Breast Neoplasms 26275461 Our findings emphasized the potential role of miR-1 as tumor suppressive miRNA in breast cancer. -other hsa-mir-491 "Carcinoma, Esophageal" 26279431 miR-491 may play a critical role in EC. -other hsa-mir-132 Granulosa Cell Tumor 26282993 Our findings suggest that miR-132 is involved in the cAMP signaling pathway and promotes estradiol synthesis via the translational repression of Nurr1 in ovarian GCs. -other hsa-mir-200a Breast Neoplasms 26283635 Identification of miR-200a as a novel suppressor of connexin 43 in breast cancer cells. -other hsa-mir-92a Diabetes Mellitus 26283734 miR-92a Corrects CD34+ Cell Dysfunction in Diabetes by Modulating Core Circadian Genes Involved in Progenitor Differentiation. -other hsa-let-7 Malignant Neoplasms [unspecific] 26285684 "and messenger RNAs and microRNAs miR-21, miR-27a, let-7, miR-451, among others." -other hsa-mir-21 Malignant Neoplasms [unspecific] 26285684 "and messenger RNAs and microRNAs miR-21, miR-27a, let-7, miR-451, among others." -other hsa-mir-27a Malignant Neoplasms [unspecific] 26285684 "and messenger RNAs and microRNAs miR-21, miR-27a, let-7, miR-451, among others." -other hsa-mir-451 Malignant Neoplasms [unspecific] 26285684 "and messenger RNAs and microRNAs miR-21, miR-27a, let-7, miR-451, among others." -other hsa-mir-335 "Leukemia, Myeloid, Acute" 26287405 Our finding suggests that bone marrow miR-335 level may be used as a marker to predict the chemotherapy response and prognosis in adult AML patients. -other hsa-mir-200 Cystic Fibrosis 26292219 Transcription Factor Hepatocyte Nuclear Factor-1¦Â (HNF-1¦Â) Regulates MicroRNA-200 Expression through a Long Noncoding RNA. -other hsa-mir-21 Leukemia 26294715 "In this issue of Blood, Junker et al delineate a novel signaling axis involving miR-21 and the tumor suppressor Pdcd4 that is essential for Notch-mediated induction of T-cell acute lymphoblastic leukemia (T-ALL)." -other hsa-mir-24 Ovarian Neoplasms 26296081 Enrichment Analysis Identifies Functional MicroRNA-Disease Associations in Humans. -other hsa-mir-454 Uveal Melanoma 26296312 Our data revealed that ectopic expression of PTEN restored the effects of miR-454 on cell proliferation and invasion in uveal melanoma cells. These findings support an oncogene role of miR-454 in development of uveal melanoma. -other hsa-mir-30 Influenza 26296570 RNA interference of influenza A virus replication by microRNA-adapted lentiviral loop short hairpin RNA. -other hsa-mir-107 "Carcinoma, Hepatocellular" 26296971 miRNA-7/21/108 contribute to HBx-induced hepatocellular carcinoma progression through suppression of maspin. -other hsa-mir-21 "Carcinoma, Hepatocellular" 26296971 miRNA-7/21/109 contribute to HBx-induced hepatocellular carcinoma progression through suppression of maspin. -other hsa-mir-7 "Carcinoma, Hepatocellular" 26296971 miRNA-7/21/107 contribute to HBx-induced hepatocellular carcinoma progression through suppression of maspin. -other hsa-mir-137 "Diabetes Mellitus, Gestational" 26302821 Our data identified a miRNA signature involvement in GDM which may contribute to macrosomia through enhancing EGFR signaling. -other hsa-mir-27a "Diabetes Mellitus, Gestational" 26302821 Our data identified a miRNA signature involvement in GDM which may contribute to macrosomia through enhancing EGFR signaling. -other hsa-mir-30d "Diabetes Mellitus, Gestational" 26302821 Our data identified a miRNA signature involvement in GDM which may contribute to macrosomia through enhancing EGFR signaling. -other hsa-mir-33a "Diabetes Mellitus, Gestational" 26302821 Our data identified a miRNA signature involvement in GDM which may contribute to macrosomia through enhancing EGFR signaling. -other hsa-mir-362 "Diabetes Mellitus, Gestational" 26302821 Our data identified a miRNA signature involvement in GDM which may contribute to macrosomia through enhancing EGFR signaling. -other hsa-mir-502 "Diabetes Mellitus, Gestational" 26302821 Our data identified a miRNA signature involvement in GDM which may contribute to macrosomia through enhancing EGFR signaling. -other hsa-mir-508 "Diabetes Mellitus, Gestational" 26302821 Our data identified a miRNA signature involvement in GDM which may contribute to macrosomia through enhancing EGFR signaling. -other hsa-mir-9 "Diabetes Mellitus, Gestational" 26302821 Our data identified a miRNA signature involvement in GDM which may contribute to macrosomia through enhancing EGFR signaling. -other hsa-mir-92a "Diabetes Mellitus, Gestational" 26302821 Our data identified a miRNA signature involvement in GDM which may contribute to macrosomia through enhancing EGFR signaling. -other hsa-mir-19a Colorectal Carcinoma 26302825 "Collectively, miR-19a played an important role in mediating EMT and metastatic behavior in CRC. It may serve as a potential marker of lymph node metastasis." -other hsa-mir-22 Aortic Stenosis 26304936 "Despite holding great promise, circulating miRNA profiling requires further refinement before translation into clinical use as a biomarker in aortic stenosis." -other hsa-mir-24 Aortic Stenosis 26304936 "Despite holding great promise, circulating miRNA profiling requires further refinement before translation into clinical use as a biomarker in aortic stenosis." -other hsa-mir-382 Aortic Stenosis 26304936 "Despite holding great promise, circulating miRNA profiling requires further refinement before translation into clinical use as a biomarker in aortic stenosis." -other hsa-mir-451a Aortic Stenosis 26304936 "Despite holding great promise, circulating miRNA profiling requires further refinement before translation into clinical use as a biomarker in aortic stenosis." -other hsa-mir-223 Multiple Sclerosis 26305248 Variants of MicroRNA Genes: Gender-Specific Associations with Multiple Sclerosis Risk and Severity. -other hsa-mir-499a Multiple Sclerosis 26305248 Variants of MicroRNA Genes: Gender-Specific Associations with Multiple Sclerosis Risk and Severity. -other hsa-mir-23a "Carcinoma, Hepatocellular" 26305257 up-regulating the expression of miR-23a may activate the positive regulatory network of p53 and miR-23a involved in the mechanism underlying the anti-tumor effect of berberine in hepatocellular carcinoma (HCC). -other hsa-mir-663b "Leukemia, Lymphocytic, Chronic, B-Cell" 26305332 Interleukin 21 Controls mRNA and MicroRNA Expression in CD40-Activated Chronic Lymphocytic Leukemia Cells. -other hsa-mir-122 Hepatitis C Virus Infection 26305877 Supporting Role for GTPase Rab27a in Hepatitis C Virus RNA Replication through a Novel miR-122-Mediated Effect. -other hsa-mir-410 Diabetes Mellitus 26307561 miR-410 enhanced hESC-derived pancreatic endoderm transplant to alleviate gestational diabetes mellitus. -other hsa-mir-26b Colorectal Carcinoma 26308439 Clinical Value of miR-26b Discriminating Ulcerative Colitis-associated Colorectal Cancer in the Subgroup of Patients with Metastatic Disease. -other hsa-mir-29 Atherosclerosis 26309238 Transcriptional and posttranscriptional mechanisms contribute to the dysregulation of elastogenesis in Schimke immuno-osseous dysplasia. -other hsa-mir-30b Gastric Neoplasms 26309359 "Our findings describe a link between miR-30b and EIF5A2, which plays an important role in mediating epithelial-mesenchymal transition." -other hsa-mir-21 Coronary Artery Disease 26310808 Local anti-miR delivery: the latest in the arsenal of drug-eluting stents -other hsa-mir-200c Breast Neoplasms 26310899 "selected miRNAs, such as miR-200c and miR-34a, may influence response to chemotherapy in several tumor types" -other hsa-mir-205 "Carcinoma, Lung, Non-Small-Cell" 26311306 Validation for histology-driven diagnosis in non-small cell lung cancer using hsa-miR-205 and hsa-miR-21 expression by two different normalization strategies. -other hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 26311306 Validation for histology-driven diagnosis in non-small cell lung cancer using hsa-miR-205 and hsa-miR-21 expression by two different normalization strategies. -other hsa-mir-10b Gastric Neoplasms 26311318 "miR-10b promotes migration and invasion through Hoxd10 in human gastric cancer cell lines and may play an important role in tumorigenesis,progression, and prognosis." -other hsa-mir-375 Diabetes Mellitus 26311337 "This review analyzes the role of miRNAs in obesity and insulin resistance, focusing on the miR-17/92, miR-143-145, miR-130, let-7, miR-221/222, miR-200, miR-223, miR-29 and miR-375 families, as well as miRNA changes by relevant tissue" -other hsa-mir-126 Atrial Fibrillation 26313139 Biological significance of miR-126 expression in atrial fibrillation and heart failure. -other hsa-mir-126 Heart Failure 26313139 Biological significance of miR-126 expression in atrial fibrillation and heart failure. -other hsa-mir-15b Pancreatic Neoplasms 26314585 Pancreatic tumours are usually very aggressive cancer with a poor prognosis. -other hsa-mir-186 Pancreatic Neoplasms 26314585 Pancreatic tumours are usually very aggressive cancer with a poor prognosis. -other hsa-mir-190 Pancreatic Neoplasms 26314585 Pancreatic tumours are usually very aggressive cancer with a poor prognosis. -other hsa-mir-200b Pancreatic Neoplasms 26314585 Pancreatic tumours are usually very aggressive cancer with a poor prognosis. -other hsa-mir-221 Pancreatic Neoplasms 26314585 Pancreatic tumours are usually very aggressive cancer with a poor prognosis. -other hsa-mir-222 Pancreatic Neoplasms 26314585 Pancreatic tumours are usually very aggressive cancer with a poor prognosis. -other hsa-mir-95 Pancreatic Neoplasms 26314585 Pancreatic tumours are usually very aggressive cancer with a poor prognosis. -other hsa-mir-15a "Carcinoma, Lung, Non-Small-Cell" 26314859 We found that induced expression of hsa-miR-15a-3p via mimic transfection sensitised cisplatin-resistant cells to apoptosis and autophagy. -other hsa-mir-338 "Carcinoma, Hepatocellular" 26315112 HBV preS2 promotes the expression of TAZ via miRNA-338-3p to enhance the tumorigenesis of hepatocellular carcinoma. -other hsa-mir-424 "Carcinoma, Hepatocellular" 26315541 MicroRNA-424 inhibits Akt3/E2F3 axis and tumor growth in hepatocellular carcinoma. -other hsa-mir-138 Colorectal Carcinoma 26316117 Downregulation of miR-138 as a Contributing Mechanism to Lcn-2 Overexpression in Colorectal Cancer with Liver Metastasis. -other hsa-mir-155 Neoplasms [unspecific] 26317550 Our results demonstrate that miR-155 inhibits the ability of cancer cells to extravasate and/or colonize at distant organs and brings additional insight into the complexity of miR-155 regulation in metastatic seeding. -other hsa-mir-31 Diabetes Mellitus 26318001 "Comparative Genomic, MicroRNA, and Tissue Analyses Reveal Subtle Differences between Non-Diabetic and Diabetic Foot Skin." -other hsa-mir-140 "Carcinoma, Embryonal" 26318829 Role of miR-140 in embryonic bone development and cancer. -other hsa-mir-21 Malignant Neoplasms [unspecific] 26320972 Toehold-mediated nonenzymatic amplification circuit on graphene oxide fluorescence switching platform for sensitive and homogeneous microRNA detection. -other hsa-mir-155 "Carcinoma, Lung, Non-Small-Cell" 26322518 These results suggest that miR-155 expression is not significantly related to non-small cell lung cancer patients except in patients from Asian and America. -other hsa-mir-145 Breast Neoplasms 26324407 Physicochemical and biological characterization of chitosan-microRNA nanocomplexes for gene delivery to MCF-7 breast cancer cells. -other hsa-mir-15b "Leukemia, Lymphocytic, Chronic, B-Cell" 26324892 "These results are the first, to our knowledge, to suggest an important role of miR-15b/16-2 loss in the pathogenesis of B-cell chronic lymphocytic leukemia." -other hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 26324892 "These results are the first, to our knowledge, to suggest an important role of miR-15b/16-2 loss in the pathogenesis of B-cell chronic lymphocytic leukemia." -other hsa-mir-142 Heart Failure 26327117 miR-142-5p has been proposed to control adaptive growth in cardiomyocytes postnatally and its increase is associated with extensive apoptosis and cardiac dysfunction in a murine heart failure model. -other hsa-mir-122 Hepatitis C Virus Infection 26330540 These results show that hnRNP K is a cellular protein that binds and affects the accumulation of miR-122. Its ability to also bind HCV RNA near the miR-122 binding site suggests a role for miR-122 recognition of HCV RNA. -other hsa-mir-200c Neoplasms [unspecific] 26334100 "In summary, TKS5 and MYLK represent two mediators of invasive behavior of cancer cells that are regulated by the ZEB1/miR-200 feedback loop." -other hsa-mir-200b "Squamous Cell Carcinoma, Esophageal" 26334393 These data highlight that suppression of the Kindlin-2-integrin ¦Â1-AKT regulatory axis is an alternative mechanism underlying the tumor suppressor function of miR-200b in ESCC. -other hsa-mir-155 Leukemia 26337206 "Altogether, these data implicate QKI in the pathophysiology of inflammation and oncogenesis where miR-155 is involved." -other hsa-mir-222 Melanoma 26338962 miR-222 could function as a biomarker for the prediction of response to ipilimumab -other hsa-mir-205 Thyroid Neoplasms 26342107 The angiogenic and tumour-suppressive roles of miRNA-205 were demonstrated for the first time in thyroid cancer. The current experiments provided specific information on the functional consequences of VEGF manipulation via miRNA on cancer. -other hsa-mir-21 "Leukemia, Myeloid, Acute" 26344648 "GRh2 may be an effective treatment for pediatric leukemia, and GRh2 may induce apoptosis of leukemia cells through miR-21-modulated suppression of Bcl-2." -other hsa-mir-30a Nephrotic Syndrome 26345917 "Analysis of the expression of HMGB-1, CXCL16, miRNA-30a, and TGF-¦Â1 in primary nephritic syndrome patients and its significance." -other hsa-mir-223 Sepsis 26348153 Exosomal miR-223 Contributes to Mesenchymal Stem Cell-Elicited Cardioprotection in Polymicrobial Sepsis. -other hsa-let-7b Vascular Disease [unspecific] 26348824 only let-7b and miR-133a were markedly upregulated. -other hsa-mir-21 Breast Neoplasms 26349663 "These results indicate that miRNAs show promising associations with prognosis in breast cancer. Moreover, specific miRNAs such as miR-21 and miR-210 can predict poor survival rates in breast cancer patients." -other hsa-mir-210 Breast Neoplasms 26349663 "These results indicate that miRNAs show promising associations with prognosis in breast cancer. Moreover, specific miRNAs such as miR-21 and miR-210 can predict poor survival rates in breast cancer patients." -other hsa-mir-126 Malignant Neoplasms [unspecific] 26351404 Our results indicated that miR-126 could act as a significant biomarker in the prognosis of various cancers. -other hsa-mir-137 "Carcinoma, Hepatocellular" 26352279 Inhibition of cell proliferation and metastasis of human hepatocellular carcinoma by miR-137 is regulated by CDC42. -other hsa-mir-126 Aplastic Anemia 26354756 Identification of novel microRNA signatures linked to acquired aplastic anemia. -other hsa-mir-145 Aplastic Anemia 26354756 Identification of novel microRNA signatures linked to acquired aplastic anemia. -other hsa-mir-199a Aplastic Anemia 26354756 Identification of novel microRNA signatures linked to acquired aplastic anemia. -other hsa-mir-223 Aplastic Anemia 26354756 Identification of novel microRNA signatures linked to acquired aplastic anemia. -other hsa-mir-143 Bladder Neoplasms 26356996 Cisplatin and Paclitaxel Alter the Expression Pattern of miR-143/145 and miR-183/96/182 Clusters in T24 Bladder Cancer Cells. -other hsa-mir-145 Bladder Neoplasms 26356996 Cisplatin and Paclitaxel Alter the Expression Pattern of miR-143/145 and miR-183/96/182 Clusters in T24 Bladder Cancer Cells. -other hsa-mir-182 Bladder Neoplasms 26356996 Cisplatin and Paclitaxel Alter the Expression Pattern of miR-143/145 and miR-183/96/182 Clusters in T24 Bladder Cancer Cells. -other hsa-mir-183 Bladder Neoplasms 26356996 Cisplatin and Paclitaxel Alter the Expression Pattern of miR-143/145 and miR-183/96/182 Clusters in T24 Bladder Cancer Cells. -other hsa-mir-96 Bladder Neoplasms 26356996 Cisplatin and Paclitaxel Alter the Expression Pattern of miR-143/145 and miR-183/96/182 Clusters in T24 Bladder Cancer Cells. -other hsa-mir-34a Breast Neoplasms 26359358 These data provide evidence for the leptin-antagonist potential of HNK and reveal the involvement of LKB1 and miR-34a. -other hsa-mir-101 Breast Neoplasms 26360780 MiRNA-101 inhibits breast cancer growth and metastasis by targeting CX chemokine receptor 7. -other hsa-mir-122 Neoplasms [unspecific] 26360933 "In conclusion, administration of TSA in hepatogenic differentiation of hAT-MSCs resulted in higher expression levels of miR-122,facilitation of differentiation, and subsequently attenuation of AFP levels." -other hsa-mir-22 Panic Disorder 26361067 This is the first report to show possible associations of miR-22 and miR-491 with genetic susceptibility to PD in a Korean population. -other hsa-mir-491 Panic Disorder 26361067 This is the first report to show possible associations of miR-22 and miR-491 with genetic susceptibility to PD in a Korean population. -other hsa-mir-302 Kidney Neoplasms 26363379 Evolutionary conservation and function of the human embryonic stem cell specific miR-302/367 cluster. -other hsa-mir-367 Kidney Neoplasms 26363379 Evolutionary conservation and function of the human embryonic stem cell specific miR-302/367 cluster. -other hsa-mir-221 Gastric Neoplasms 26364844 The miR-221/miR-222-RECK axis might be an important path modulating H. pylori infection-related gastric cancer development. -other hsa-mir-222 Gastric Neoplasms 26364844 The miR-221/miR-222-RECK axis might be an important path modulating H. pylori infection-related gastric cancer development. -other hsa-mir-486 Lung Fibrosis 26370615 The Anti-fibrotic Effects and Mechanisms of MicroRNA-486-5p in Pulmonary Fibrosis. -other hsa-mir-16 Bladder Neoplasms 26373319 "Together, our results revealed that urothelial carcinoma-associated 1 regulated the expression of GLS2 through interfering with miR-16, and repressed ROS formation in bladder cancer cells." -other hsa-mir-148b "Carcinoma, Lung, Non-Small-Cell" 26377406 Our findings demonstrated that miR-148b may play a role as independent prognostic factor for patients with NSCLC. -other hsa-mir-140 Breast Neoplasms 26378051 the existence of common pathways driving breast carcinogenesis in both BRCA1 and BRCA2 germ-line mutation carriers. -other hsa-mir-320c Breast Neoplasms 26378051 the existence of common pathways driving breast carcinogenesis in both BRCA1 and BRCA2 germ-line mutation carriers. -other hsa-mir-335 Breast Neoplasms 26378051 the existence of common pathways driving breast carcinogenesis in both BRCA1 and BRCA2 germ-line mutation carriers. -other hsa-mir-486 Breast Neoplasms 26378051 the existence of common pathways driving breast carcinogenesis in both BRCA1 and BRCA2 germ-line mutation carriers. -other hsa-mir-200a Retinoblastoma 26379276 Novel miRNA-31 and miRNA-200a-Mediated Regulation of Retinoblastoma Proliferation. -other hsa-mir-31 Retinoblastoma 26379276 Novel miRNA-31 and miRNA-200a-Mediated Regulation of Retinoblastoma Proliferation. -other hsa-mir-375 Osteosarcoma 26381132 "Formononetin has inhibitory effects on the proliferation of U2SO cells, both in vitro and in vivo. This antitumor effect is directly correlated with formononetin concentration." -other hsa-mir-130a Myeloma 26389804 "Together, our data suggest connection between lower level of microRNA-130a and extramedullary disease and prompt further work to evaluate this miRNA as a marker of extramedullary disease in multiple myeloma." -other hsa-mir-122 "Carcinoma, Lung, Non-Small-Cell" 26389880 These results indicate that miR-122 would be a novel strategy for NSCLC radiation-therapy. -other hsa-mir-143 Colorectal Carcinoma 26392389 "These findings warrant further studies to investigate the relationship between miR-143, FXYD3 and fluoropyrimidines, and the clinical utility of miR-143 as biomarker." -other hsa-mir-221 Osteosarcoma 26397386 "Taken together, our results suggest that miR-221 enhances the proliferation,invasion and migration ability of osteosarcoma cells partly by suppressing PTEN." -other hsa-mir-146b Glioma 26397753 "In conclusion, the inhibition of miR-146b may increase hypoxia-induced cardiomyocyte apoptosis." -other hsa-mir-765 "Carcinoma, Breast" 26398721 These results provided novel insight into the regulatory mechanism of EMP3 in primary breast carcinoma. -other hsa-mir-199a Breast Neoplasms 26399456 "Thus, miR-199a/b-3p functions as a tumor suppressor and has an important role in breast cancer metastasis through PAK4/MEK/ERK signaling pathway." -other hsa-mir-199b Breast Neoplasms 26399456 "Thus, miR-199a/b-3p functions as a tumor suppressor and has an important role in breast cancer metastasis through PAK4/MEK/ERK signaling pathway." -other hsa-mir-183 Breast Neoplasms 26400174 "In conclusion,our findings provide evidence that post-transcriptional studies of BRCA will benefit from transcending the one-locus-one-miRNA paradigm and taking into account all isoforms from each miRNA locus as well as the patient's race." -other hsa-mir-23a Granulosa Cell Tumor 26400397 "These findings provide an improved understanding of the mechanisms underlying granulosa cell apoptosis, which could potentially be used for future clinical applications." -other hsa-mir-27a Granulosa Cell Tumor 26400397 "These findings provide an improved understanding of the mechanisms underlying granulosa cell apoptosis, which could potentially be used for future clinical applications." -other hsa-mir-183 "Carcinoma, Hepatocellular" 26400524 This study revealed a novel miR-21/miR-183-SOCS7 axis that might play an important role in modulating cell growth and invasion of HCC cells. -other hsa-mir-21 "Carcinoma, Hepatocellular" 26400524 This study revealed a novel miR-21/miR-183-SOCS6 axis that might play an important role in modulating cell growth and invasion of HCC cells. -other hsa-mir-1 Acute Kidney Failure 26400542 "Ramipril reduced cardiac hypertrophy, attenuated the increase in microRNA-212 and microRNA-132, and significantly increased microRNA-133 and microRNA-1 expression." -other hsa-mir-146 Immune System Disease [unspecific] 26400897 "Present review is focused on the current knowledge about the action of medicaments,microRNA molecules, exosomes and related vesicles on macrophages leading to modulation of their biological activity." -other hsa-mir-17 "Adenocarcinoma, Lung" 26402252 Identification of Biomarker and Co-Regulatory Motifs in Lung Adenocarcinoma Based on Differential Interactions. -other hsa-mir-423 Colorectal Carcinoma 26402653 "In conclusion, our findings demonstrated a critical impact of miR-423-3p on CRC growth." -other hsa-mir-532 Alzheimer Disease 26402772 "Although we could not consistently separate AD patients and controls in the whole group, we have found indications miRNA in CSF are able to reflect aging and perhaps also heterogeneity in AD. Further investigation requires optimizing RNA input, while maintaining strict age matching." -other hsa-mir-30c "Carcinoma, Esophageal" 26402921 "Factors such as core promoter-binding protein (CPBP), nuclear factor of activated T-cells 1 (NFAT-1), miR-30c-5p, were located in the central hub of this network, highlighting their vital roles in esophageal tumorigenesis." -other hsa-mir-34a Alcoholic Hepatitis 26403328 "These results constitute a demonstration of the altered regulation of miR-34a and miR-483-3p in the livers of AH and mice fed DDC where MDBs formed, providing further insight into the mechanism of MDB formation mediated by miR-34a and miR-483-3p in AH." -other hsa-mir-483 Alcoholic Hepatitis 26403328 "These results constitute a demonstration of the altered regulation of miR-34a and miR-483-3p in the livers of AH and mice fed DDC where MDBs formed, providing further insight into the mechanism of MDB formation mediated by miR-34a and miR-483-3p in AH." -other hsa-mir-34a "Carcinoma, Lung, Non-Small-Cell" 26406332 Aptamer-Dendrimer Bioconjugates for Targeted Delivery of miR-34a Expressing Plasmid and Antitumor Effects in Non-Small Cell Lung Cancer Cells. -other hsa-mir-21 Breast Neoplasms 26411332 The miR-21-triggered self-assembly of DNA nanostructures can also serve as a remarkable signal amplification platform to achieve ultrasensitive detection of miR-21 from as low as 10 MCF-7 human breast cancer cells. -other hsa-mir-124 Rhinosinusitis 26413631 The results from this study may further reveal the relationship between miRNA expressions and inflammation. These results can also provide an important mechanism (primitive data) on the occurrence of chronic sinusitis and nasal polyps. -other hsa-mir-125b Rhinosinusitis 26413631 The results from this study may further reveal the relationship between miRNA expressions and inflammation. These results can also provide an important mechanism (primitive data) on the occurrence of chronic sinusitis and nasal polyps. -other hsa-mir-146a Rhinosinusitis 26413631 The results from this study may further reveal the relationship between miRNA expressions and inflammation. These results can also provide an important mechanism (primitive data) on the occurrence of chronic sinusitis and nasal polyps. -other hsa-mir-155 Rhinosinusitis 26413631 The results from this study may further reveal the relationship between miRNA expressions and inflammation. These results can also provide an important mechanism (primitive data) on the occurrence of chronic sinusitis and nasal polyps. -other hsa-mir-181b Rhinosinusitis 26413631 The results from this study may further reveal the relationship between miRNA expressions and inflammation. These results can also provide an important mechanism (primitive data) on the occurrence of chronic sinusitis and nasal polyps. -other hsa-mir-26b Rhinosinusitis 26413631 The results from this study may further reveal the relationship between miRNA expressions and inflammation. These results can also provide an important mechanism (primitive data) on the occurrence of chronic sinusitis and nasal polyps. -other hsa-mir-92a Rhinosinusitis 26413631 The results from this study may further reveal the relationship between miRNA expressions and inflammation. These results can also provide an important mechanism (primitive data) on the occurrence of chronic sinusitis and nasal polyps. -other hsa-let-7e "Carcinoma, Thyroid, Papillary" 26414548 Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations. -other hsa-mir-21 Renal Fibrosis 26415649 "Collectively, these data present a unified model for a key role for miR-21 in the regulation of renal tubular extracellular matrix (ECM) synthesis and accumulation and provide important insights into the molecular pathways implicated in the progression of DN." -other hsa-let-7a Prostate Neoplasms 26415820 "In this review, we focus on the regulation of miRNAs in prostate cancer and their mechanisms which contribute to prostate carcinogenesis. The relation of miRNAs with androgen signaling is highlighted and the prospects of miRNAs for clinical therapies are discussed." -other hsa-mir-145 Prostate Neoplasms 26415820 "In this review, we focus on the regulation of miRNAs in prostate cancer and their mechanisms which contribute to prostate carcinogenesis. The relation of miRNAs with androgen signaling is highlighted and the prospects of miRNAs for clinical therapies are discussed." -other hsa-mir-18a Prostate Neoplasms 26415820 "In this review, we focus on the regulation of miRNAs in prostate cancer and their mechanisms which contribute to prostate carcinogenesis. The relation of miRNAs with androgen signaling is highlighted and the prospects of miRNAs for clinical therapies are discussed." -other hsa-mir-218 Prostate Neoplasms 26415820 "In this review, we focus on the regulation of miRNAs in prostate cancer and their mechanisms which contribute to prostate carcinogenesis. The relation of miRNAs with androgen signaling is highlighted and the prospects of miRNAs for clinical therapies are discussed." -other hsa-mir-23b Prostate Neoplasms 26415820 "In this review, we focus on the regulation of miRNAs in prostate cancer and their mechanisms which contribute to prostate carcinogenesis. The relation of miRNAs with androgen signaling is highlighted and the prospects of miRNAs for clinical therapies are discussed." -other hsa-mir-296 Prostate Neoplasms 26415820 "In this review, we focus on the regulation of miRNAs in prostate cancer and their mechanisms which contribute to prostate carcinogenesis. The relation of miRNAs with androgen signaling is highlighted and the prospects of miRNAs for clinical therapies are discussed." -other hsa-mir-429 Prostate Neoplasms 26415820 "In this review, we focus on the regulation of miRNAs in prostate cancer and their mechanisms which contribute to prostate carcinogenesis. The relation of miRNAs with androgen signaling is highlighted and the prospects of miRNAs for clinical therapies are discussed." -other hsa-mir-497 Prostate Neoplasms 26415820 "In this review, we focus on the regulation of miRNAs in prostate cancer and their mechanisms which contribute to prostate carcinogenesis. The relation of miRNAs with androgen signaling is highlighted and the prospects of miRNAs for clinical therapies are discussed." -other hsa-mir-134 Breast Neoplasms 26416415 miR-134 in extracellular vesicles reduces triple-negative breast cancer aggression and increases drug sensitivity. -other hsa-mir-200b "Adenocarcinoma, Lung" 26416454 These results provide new evidence for the mechanisms governing the microRNA (miRNA)-ATG12 network and their possible contribution to autophagy modulation and LAD chemoresistance. -other hsa-mir-574 Breast Neoplasms 26416693 Next generation sequencing profiling identifies miR-574-3p and miR-660-5p as potential novel prognostic markers for breast cancer. -other hsa-mir-660 Breast Neoplasms 26416693 Next generation sequencing profiling identifies miR-574-3p and miR-660-5p as potential novel prognostic markers for breast cancer. -other hsa-mir-4286 Pregnancy Complications [unspecific] 26418635 The findings highlight miRNAs in the human cervix as novel responders to maternal chemical exposure during pregnancy. -other hsa-mir-575 Pregnancy Complications [unspecific] 26418635 The findings highlight miRNAs in the human cervix as novel responders to maternal chemical exposure during pregnancy. -other hsa-let-7a Neoplasms [unspecific] 26420675 "Target-Catalyzed DNA Four-Way Junctions for CRET Imaging of MicroRNA,Concatenated Logic Operations, and Self-Assembly of DNA Nanohydrogels for Targeted Drug Delivery." -other hsa-mir-29a Hepatitis C Virus Infection 26429314 "This study showed that HCV infection might abrogate NK cytotoxic potential through altering PU.1, NKG2D receptor and perforin molecules." -other hsa-mir-222 Breast Neoplasms 26432333 exosomes transmit drug resistance through delivering miR-222. -other hsa-mir-155 Sepsis 26433115 A higher level of miR-155 indicated a more severe condition and poorer prognosis in sepsis patients. The possible underlying mechanism could be that miR-155 induces an increased percentage of CD39(+) Tregs and thus immunosuppression. -other hsa-mir-21 Glioblastoma 26433199 Dissociated microglia and monocytes/macrophages from tumor-bearing brains revealed increased levels of miR-21 and reduced levels of c-Myc mRNA. -other hsa-mir-21 Glioma 26433199 Dissociated microglia and monocytes/macrophages from tumor-bearing brains revealed increased levels of miR-21 and reduced levels of c-Myc mRNA. -other hsa-mir-204 Breast Neoplasms 26436206 Trichostatin A and Tamoxifen inhibit breast cancer cell growth by miR-204 and ER¦Á reducing AKT/mTOR pathway. -other hsa-mir-196b "Leukemia, Myeloid, Acute" 26436590 "The lincRNA HOTAIRM1, located in the HOXA genomic region, is expressed in acute myeloid leukemia, impacts prognosis in patients in the intermediate-risk cytogenetic category, and is associated with a distinctive microRNA signature." -other hsa-mir-25 Thyroid Neoplasms 26437444 "Together, our data suggest that IL-23 induces migration and invasion in thyroid cancer cells by mediating the miR-25/SOCS4 signaling pathway." -other hsa-mir-141 Neoplasms [unspecific] 26439017 Coupling hybridization chain reaction with catalytic hairpin assembly enables non-enzymatic and sensitive fluorescent detection of microRNA cancer biomarkers. -other hsa-mir-143 Breast Neoplasms 26439035 "UCA1 can directly interact with miR-143, lower its expression and affect its downstream regulation. Therefore, the UCA1-miR-143 axis constitutes a part of the oncogenic role of UCA1 in breast cancer." -other hsa-mir-23a Liver Neoplasms 26439986 we found expression of miR-23a was related to p53 functional status in the male-derived liver cell-lines -other hsa-mir-212 Prostate Neoplasms 26439987 "In conclusion, our study indicates a functional role of miR-212 in PCa and suggests the development of miR-212 based therapies." -other hsa-mir-16 "Colitis, Ulcerative" 26440311 "miR-16 suppression during the colitis-to-cancer sequence in colon epithelial cells, which was rescued by drinking Cl-amidine." -other hsa-mir-10b Pancreatic Neoplasms 26444644 "Our findings suggest that this unique technique can be used to design novel diagnostic strategies for pancreatic and other cancers based on the direct quantitative measurement of plasma and exosome microRNAs, and can be readily extended to other diseases with identifiable microRNA signatures." -other hsa-mir-210 Neoplasms [unspecific] 26446394 Potential Role of MicroRNA-210 as Biomarker in Human Cancers Detection: A Meta-Analysis. -other hsa-mir-130b Osteosarcoma 26446495 "Taken together, our data indicated that high miR-130b level and low level of miR-218 are associated with poor clinicopathological characteristics.Furthermore, miR-130b may play a key role in the progression of osteosarcoma." -other hsa-mir-218 Osteosarcoma 26446495 "Taken together, our data indicated that high miR-130b level and low level of miR-218 are associated with poor clinicopathological characteristics.Furthermore, miR-130b may play a key role in the progression of osteosarcoma." -other hsa-mir-125b Coronary Artery Disease 26446730 "We found several synergistic effects between miR-125b and classical risk factors, such as age,sex, CR, FBG and HDL-C; the proportion of CHD attributable to the interaction of miR-125b and age was as high as 80%. Therefore, miR-125b was shown to play an important role in individual's susceptibility to developing CHD." -other hsa-mir-26b Schizophrenia 26450699 "the notion that microRNAs fine-tune the amount of proteins acting in the same biological pathways in schizophrenia, giving further support to the emerging theory of competing endogenous RNAs." -other hsa-mir-335 Schizophrenia 26450699 "the notion that microRNAs fine-tune the amount of proteins acting in the same biological pathways in schizophrenia, giving further support to the emerging theory of competing endogenous RNAs." -other hsa-mir-221 Atherosclerosis 26451018 "Atherosclerotic plaque rupture is accompanied by a loss of miR-221 and miR-222 and an increase in p27Kip1 mRNA expression in the plaque shoulder,suggesting an association between these miRNAs and atherosclerotic plaque stability." -other hsa-mir-222 Atherosclerosis 26451018 "Atherosclerotic plaque rupture is accompanied by a loss of miR-221 and miR-222 and an increase in p27Kip1 mRNA expression in the plaque shoulder,suggesting an association between these miRNAs and atherosclerotic plaque stability." -other hsa-mir-106a Lung Neoplasms 26451608 These results encourage exploiting the MSC test for lung cancer monitoring in LDCT screening for lung cancer. -other hsa-mir-17 Lung Neoplasms 26451608 These results encourage exploiting the MSC test for lung cancer monitoring in LDCT screening for lung cancer. -other hsa-mir-197 Lung Neoplasms 26451608 These results encourage exploiting the MSC test for lung cancer monitoring in LDCT screening for lung cancer. -other hsa-mir-19b Lung Neoplasms 26451608 These results encourage exploiting the MSC test for lung cancer monitoring in LDCT screening for lung cancer. -other hsa-mir-486 Lung Neoplasms 26451608 These results encourage exploiting the MSC test for lung cancer monitoring in LDCT screening for lung cancer. -other hsa-mir-92a Lung Neoplasms 26451608 These results encourage exploiting the MSC test for lung cancer monitoring in LDCT screening for lung cancer. -other hsa-mir-506 "Carcinoma, Colon" 26452129 "Taking together, our study sheds light on the role of miR-506 as a suppressor for tumor growth and metastasis and raises the intriguing possibility that miR-506 may serve as a new potential marker for monitoring and treating colon cancer." -other hsa-mir-1254 "Squamous Cell Carcinoma, Head and Neck" 26452218 "Together, we demonstrate the feasibility of using a miRNA signature to predict the clinical responsiveness of HNSCC radiotherapy." -other hsa-mir-150 "Squamous Cell Carcinoma, Head and Neck" 26452218 "Together, we demonstrate the feasibility of using a miRNA signature to predict the clinical responsiveness of HNSCC radiotherapy." -other hsa-mir-16 "Squamous Cell Carcinoma, Head and Neck" 26452218 "Together, we demonstrate the feasibility of using a miRNA signature to predict the clinical responsiveness of HNSCC radiotherapy." -other hsa-mir-21 "Squamous Cell Carcinoma, Head and Neck" 26452218 "Together, we demonstrate the feasibility of using a miRNA signature to predict the clinical responsiveness of HNSCC radiotherapy." -other hsa-mir-210 "Squamous Cell Carcinoma, Head and Neck" 26452218 "Together, we demonstrate the feasibility of using a miRNA signature to predict the clinical responsiveness of HNSCC radiotherapy." -other hsa-mir-29 "Squamous Cell Carcinoma, Head and Neck" 26452218 "Together, we demonstrate the feasibility of using a miRNA signature to predict the clinical responsiveness of HNSCC radiotherapy." -other hsa-mir-373 "Squamous Cell Carcinoma, Head and Neck" 26452218 "Together, we demonstrate the feasibility of using a miRNA signature to predict the clinical responsiveness of HNSCC radiotherapy." -other hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 26453197 Up-Regulation of miR-21 Expression Predicate Advanced Clinicopathological Features and Poor Prognosis in Patients with Non-Small Cell Lung Cancer. -other hsa-mir-221 Astrocytoma 26454049 Loss of miR-221 function and cytotoxicity induced by the miR-221 DOXO MB provides combined therapeutic efficacy against cancers. -other hsa-mir-106b Hepatitis B Virus Infection 26456479 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. -other hsa-mir-106b Liver Cirrhosis 26456479 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. -other hsa-mir-122 Hepatitis B Virus Infection 26456479 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. -other hsa-mir-122 Liver Cirrhosis 26456479 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. -other hsa-mir-181b Hepatitis B Virus Infection 26456479 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. -other hsa-mir-181b Liver Cirrhosis 26456479 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. -other hsa-mir-185 Hepatitis B Virus Infection 26456479 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. -other hsa-mir-185 Liver Cirrhosis 26456479 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. -other hsa-mir-18a Hepatitis B Virus Infection 26456479 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. -other hsa-mir-18a Liver Cirrhosis 26456479 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. -other hsa-mir-21 Hepatitis B Virus Infection 26456479 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. -other hsa-mir-21 Liver Cirrhosis 26456479 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. -other hsa-mir-29c Hepatitis B Virus Infection 26456479 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. -other hsa-mir-29c Liver Cirrhosis 26456479 Our results provide important information for developing novel diagnostic tools for distinguishing chronic HBV hepatitis and their corresponding cirrhosis. -other hsa-mir-5193 Hepatitis B Virus Infection 26456535 "Therefore, miR-5193 might be useful and have a vital role for inhibition of HBV replication in the future." -other hsa-mir-101-2 Gastric Neoplasms 26458815 "Our expression analyses and in vitro functional assays suggest that miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in primary GCs as well as in GC-derived AGS cells." -other hsa-mir-125b-2 Gastric Neoplasms 26458815 "Our expression analyses and in vitro functional assays suggest that miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in primary GCs as well as in GC-derived AGS cells." -other hsa-mir-451a Gastric Neoplasms 26458815 "Our expression analyses and in vitro functional assays suggest that miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in primary GCs as well as in GC-derived AGS cells." -other hsa-mir-19b Coronary Artery Disease 26459935 Therefore our results indicate that miR-19b plays a key role in the attenuation of TNF-¦Á-induced endothelial cell apoptosis and that this function is closely linked to the Apaf1/caspase-dependent pathway. -other hsa-mir-650 Influenza 26460926 Together these findings reveal a novel link between miR-650 and the innate immune response in human MDDCs. -other hsa-mir-214 "Adenocarcinoma, Lung" 26462018 "Collectively, this study uncovers a previously unappreciated miR-214-Sufu pathway in controlling EMT and metastasis of LAD and suggests that interfering with miR-214 and Sufu could be a viable approach to treat late stage metastatic LAD patients." -other hsa-mir-9 "Leukemia, Myeloid, Acute" 26464168 Expression of a passenger miR-9* predicts favorable outcome in adults with acute myeloid leukemia less than 60 years of age. -other hsa-mir-184 Glioma 26464691 Inhibitory effect of miR-184 on the potential of proliferation and invasion in human glioma and breast cancer cells in vitro. -other hsa-mir-155 Lung Neoplasms 26467212 The candidate oncogene (MCRS1) promotes the growth of human lung cancer cells via the miR-155-Rb1 pathway. -other hsa-mir-1290 Human Immunodeficiency Virus Infection 26469550 "Our study emphasizes the role of cellular miRNAs in HIV-1 latency regulation, and it suggests that inhibitors of miR-196b and miR-1290 could be used to activate latent HIV-1." -other hsa-mir-196b Human Immunodeficiency Virus Infection 26469550 "Our study emphasizes the role of cellular miRNAs in HIV-1 latency regulation, and it suggests that inhibitors of miR-196b and miR-1290 could be used to activate latent HIV-1." -other hsa-mir-21 Glioma 26473373 These results suggest that miR-21 is associated with regulation of the migratory ability and survival in human glioma cells. These findings suggest novel mechanisms of malignancy and new potential combinatorial strategies for the management of malignant glioma. -other hsa-mir-27b Neoplasms [unspecific] 26473412 These findings show that miR-27b functions as a tumor suppressor by controlling ARFGEF1 and the paxillin/c-Src circuit at focal adhesions. -other hsa-mir-21 Human Immunodeficiency Virus Infection 26473639 "These data reveal specific regulation of plasma miR-21 in HIV,HIV/HCV coinfection, and PAH and suggest that miR-21 may integrate complex disease-specific signaling in the setting of HIV infection." -other hsa-mir-17 Neoplasms [unspecific] 26479035 "Our findings signify the dynamic and reciprocal cross-talk between tumour cells and the metastatic niche; importantly, they provide new opportunities for effective anti-metastasis therapies, especially of consequence for brain metastasis patients" -other hsa-mir-18 Neoplasms [unspecific] 26479035 "Our findings signify the dynamic and reciprocal cross-talk between tumour cells and the metastatic niche; importantly, they provide new opportunities for effective anti-metastasis therapies, especially of consequence for brain metastasis patients" -other hsa-mir-19a Neoplasms [unspecific] 26479035 "Our findings signify the dynamic and reciprocal cross-talk between tumour cells and the metastatic niche; importantly, they provide new opportunities for effective anti-metastasis therapies, especially of consequence for brain metastasis patients" -other hsa-mir-19b Neoplasms [unspecific] 26479035 "Our findings signify the dynamic and reciprocal cross-talk between tumour cells and the metastatic niche; importantly, they provide new opportunities for effective anti-metastasis therapies, especially of consequence for brain metastasis patients" -other hsa-mir-19b-1 Neoplasms [unspecific] 26479035 "Our findings signify the dynamic and reciprocal cross-talk between tumour cells and the metastatic niche; importantly, they provide new opportunities for effective anti-metastasis therapies, especially of consequence for brain metastasis patients" -other hsa-mir-20a Neoplasms [unspecific] 26479035 "Our findings signify the dynamic and reciprocal cross-talk between tumour cells and the metastatic niche; importantly, they provide new opportunities for effective anti-metastasis therapies, especially of consequence for brain metastasis patients" -other hsa-mir-92 Neoplasms [unspecific] 26479035 "Our findings signify the dynamic and reciprocal cross-talk between tumour cells and the metastatic niche; importantly, they provide new opportunities for effective anti-metastasis therapies, especially of consequence for brain metastasis patients" -other hsa-mir-92-1 Neoplasms [unspecific] 26479035 "Our findings signify the dynamic and reciprocal cross-talk between tumour cells and the metastatic niche; importantly, they provide new opportunities for effective anti-metastasis therapies, especially of consequence for brain metastasis patients" -other hsa-mir-125b-1 Neuroblastoma 26480000 "Identification of linc-NeD125, a novel long non coding RNA that hosts miR-125b-1 and negatively controls proliferation of human neuroblastoma cells." -other hsa-mir-21 "Carcinoma, Esophageal" 26481465 "In this study, miR-21 was identified as an independent prognostic biomarker for DSS in patients with EAC whereas miR-21 failed to show independent prognostic significance in ESCC. High miR-375 was not associated with enhanced survival in either histology." -other hsa-mir-375 "Carcinoma, Esophageal" 26481465 "In this study, miR-21 was identified as an independent prognostic biomarker for DSS in patients with EAC whereas miR-21 failed to show independent prognostic significance in ESCC. High miR-375 was not associated with enhanced survival in either histology." -other hsa-mir-1236 Kidney Neoplasms 26481573 Kidney cancer: RNA activation in RCC: p21 and miR-1236 are a promising pair. -other hsa-mir-17 "Carcinoma, Lung, Non-Small-Cell" 26482648 Our study indicates that miR-17 and miR-92 families play important roles in cisplatin resistance and can be used as potential biomarkers for better predicting the clinical response to platinum-based chemotherapy in NSCLC. -other hsa-mir-92a "Carcinoma, Lung, Non-Small-Cell" 26482648 Our study indicates that miR-17 and miR-92 families play important roles in cisplatin resistance and can be used as potential biomarkers for better predicting the clinical response to platinum-based chemotherapy in NSCLC. -other hsa-mir-22 Emphysema 26482970 MicroRNA miR-22 drives T(H)17 responses in emphysema. -other hsa-mir-486 Coronary Artery Disease 26485305 MiR-486 and miR-92a Identified in Circulating HDL Discriminate between Stable and Vulnerable Coronary Artery Disease Patients. -other hsa-mir-92a Coronary Artery Disease 26485305 MiR-486 and miR-92a Identified in Circulating HDL Discriminate between Stable and Vulnerable Coronary Artery Disease Patients. -other hsa-mir-497 "Carcinoma, Lung, Non-Small-Cell" 26485685 "Together, our data demonstrate a previously unappreciated role for miR-497 in suppression of VEGF-A-mediated NSCLC cancer cell growth and invasion." -other hsa-mir-21 Breast Neoplasms 26486006 Advances in Research on miR-21 and Breast Cancer. -other hsa-mir-146a Leukemia 26487345 Transcription factor and miRNA co-regulatory network reveals shared and specific regulators in the development of B cell and T cell. -other hsa-mir-20 Leukemia 26487345 Transcription factor and miRNA co-regulatory network reveals shared and specific regulators in the development of B cell and T cell. -other hsa-mir-122 Kidney Injury 26489516 "In mice,miR-122-5p, miR-151a-3p and miR-382-5p specifically reported APAP toxicity -being unaffected by drug-induced kidney injury. Profiling of acetaminophen toxicity identified multiple miRNAs that report acute liver injury and potential biomarkers of drug-induced kidney injury." -other hsa-mir-122 Liver Injury 26489516 "In mice,miR-122-5p, miR-151a-3p and miR-382-5p specifically reported APAP toxicity -being unaffected by drug-induced kidney injury. Profiling of acetaminophen toxicity identified multiple miRNAs that report acute liver injury and potential biomarkers of drug-induced kidney injury." -other hsa-mir-151a Kidney Injury 26489516 "In mice,miR-122-5p, miR-151a-3p and miR-382-5p specifically reported APAP toxicity -being unaffected by drug-induced kidney injury. Profiling of acetaminophen toxicity identified multiple miRNAs that report acute liver injury and potential biomarkers of drug-induced kidney injury." -other hsa-mir-151a Liver Injury 26489516 "In mice,miR-122-5p, miR-151a-3p and miR-382-5p specifically reported APAP toxicity -being unaffected by drug-induced kidney injury. Profiling of acetaminophen toxicity identified multiple miRNAs that report acute liver injury and potential biomarkers of drug-induced kidney injury." -other hsa-mir-382 Kidney Injury 26489516 "In mice,miR-122-5p, miR-151a-3p and miR-382-5p specifically reported APAP toxicity -being unaffected by drug-induced kidney injury. Profiling of acetaminophen toxicity identified multiple miRNAs that report acute liver injury and potential biomarkers of drug-induced kidney injury." -other hsa-mir-382 Liver Injury 26489516 "In mice,miR-122-5p, miR-151a-3p and miR-382-5p specifically reported APAP toxicity -being unaffected by drug-induced kidney injury. Profiling of acetaminophen toxicity identified multiple miRNAs that report acute liver injury and potential biomarkers of drug-induced kidney injury." -other hsa-mir-122 Coronary Artery Disease 26490079 MicroRNA Biomarkers for Coronary Artery Disease -other hsa-mir-96 Congenital Deafness 26490746 "Cx26-mediated intercellular communication is required for cochlear development and that deficiency of Cx26 can impair miRNA-mediated intercellular genetic communication in the cochlea, which may lead to cochlear developmental disorders and eventually congenital deafness as previously reported." -other hsa-mir-26a Colorectal Carcinoma 26494299 microRNA-26a and -584 inhibit the colorectal cancer progression through inhibition of the binding of hnRNP A1-CDK6 mRNA. -other hsa-mir-584 Colorectal Carcinoma 26494299 microRNA-26a and -584 inhibit the colorectal cancer progression through inhibition of the binding of hnRNP A1-CDK6 mRNA. -other hsa-mir-130a "Leukemia, Myeloid, Chronic" 26494558 Functional studies of miR-130a on the inhibitory pathways of apoptosis in patients with chronic myeloid leukemia. -other hsa-let-7d Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-100 Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-107 Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-129 Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-132 Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-136 Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-146b Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-148a Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-152 Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-15a Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-15b Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-160 Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-192 Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-193a Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-193b Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-194 Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-200a Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-200b Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-203 Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-205 Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-26b Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-29b Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-30a Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-30b Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-31 Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-335 Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-497 Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-664 Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-703 Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-709 Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-801 Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-923 Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-93 Peritoneal Dialysis Failure 26495316 microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis. -other hsa-mir-125a Multiple Myeloma 26496024 "Members of the miR-99b/let-7e/miR-125a cluster, or of its paralog, upregulated in t(4;14), were connected with the specific transcription factors PBX1 and CEBPA and several target genes." -other hsa-mir-378 Colorectal Carcinoma 26496897 Lauric acid can improve the sensitization of Cetuximab in KRAS/BRAF mutated colorectal cancer cells by retrievable microRNA-378 expression. -other hsa-mir-1 Breast Neoplasms 26497855 MicroRNA-1 down-regulates proliferation and migration of breast cancer stem cells by inhibiting the Wnt/¦Â-catenin pathway. -other hsa-mir-135a Pain 26498117 "These results show that circulating miRNA predict persistent severe axial pain after MVC and suggest that they may be involved in the pathogenesis of post-traumatic musculoskeletal pain. However, further studies are needed to determine if these miRNA play a direct causal role." -other hsa-mir-3613 Pain 26498117 "These results show that circulating miRNA predict persistent severe axial pain after MVC and suggest that they may be involved in the pathogenesis of post-traumatic musculoskeletal pain. However, further studies are needed to determine if these miRNA play a direct causal role." -other hsa-mir-33a Influenza 26498766 "In conclusion, we found that miR-33a is a novel inhibitory factor for influenza A virus replication." -other hsa-mir-21 Neoplasms [unspecific] 26503645 "Therefore,this study presents an improved method with shorten time to prepare a (99m)Tc radiolabeled AMO. In addition, it supports the role of (99m)Tc-AMO for noninvasive visualization of miR-21 in malignant tumors." -other hsa-mir-122 Chronic Hepatitis C 26503793 We demonstrated a substantial and prolonged decrease in plasma miR-122 levels in patients dosed with miravirsen. Plasma levels of other miRNAs were not significantly affected by antagonising miR-122. -other hsa-mir-146a Sjogren Syndrome 26505653 Dysregulated co-stimulatory molecule expression in a Sj?gren's syndrome mouse model with potential implications by microRNA-146a. -other hsa-let-7d Epilepsy 26506013 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. -other hsa-mir-106b Epilepsy 26506013 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. -other hsa-mir-130a Epilepsy 26506013 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. -other hsa-mir-146a Epilepsy 26506013 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. -other hsa-mir-155 Epilepsy 26506013 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. -other hsa-mir-15a Epilepsy 26506013 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. -other hsa-mir-194 Epilepsy 26506013 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. -other hsa-mir-221 Epilepsy 26506013 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. -other hsa-mir-222 Epilepsy 26506013 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. -other hsa-mir-223 Epilepsy 26506013 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. -other hsa-mir-301a Epilepsy 26506013 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. -other hsa-mir-30b Epilepsy 26506013 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. -other hsa-mir-342 Epilepsy 26506013 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. -other hsa-mir-4446 Epilepsy 26506013 This review highlights the immunological features underlying the pathogenesis of epileptic seizures and the possible miRNA mediated approaches for drug resistant epilepsies that modulate the immune-mediated pathogenesis. -other hsa-mir-33a Breast Neoplasms 26507842 These findings identified miR-33a as a negative regulator of breast cancer cell proliferation and metastasis. -other hsa-mir-34a Cardiomegaly 26508703 Neonatal HHR had higher cardiac telomerase activity and expression of Tert and miR-34a. -other hsa-mir-223 Disease of Metabolism 26512640 "the roles of miR-223 during the processes of osteoclast and osteoblast differentiation, as well as the potential clinical applications of miR-223 in bone metabolism disorders." -other hsa-mir-3619 "Carcinoma, Lung, Non-Small-Cell" 26512718 "Our data demonstrate a previously unappreciated role for miR-3619-5p,in suppression of ¦Â-catenin-mediated cancer growth and invasion in NSCLC cells,and highlight miR-3619-5p as a novel cancer suppressor in NSCLC." -other hsa-mir-22 Breast Neoplasms 26512777 These results provide mechanistic insight into TIP60 regulation and evidence for the utility of the combination of TIP60 and miR-22 as prognostic indicator of breast cancer progression. -other hsa-mir-371a Cardiomyopathy 26512958 "In conclusion, the presence of a g2252c polymorphism in the BAG3 3'-UTR determines loss of miR-371a-5p binding and results in an altered response to epi, potentially representing a new molecular mechanism that contributes to TTC pathogenesis." -other hsa-mir-429 "Carcinoma, Gastric" 26513239 Our data suggest that miR-429 suppression in GC promotes Bcl-2-mediated cancer cell survival against chemotherapy-induced cell death.Re-expression of miR-429 levels in GC cells may enhance cancer apoptosis during chemotherapy. -other hsa-mir-122 "Carcinoma, Hepatocellular" 26514126 The findings suggest that the export of miR-122 via AMSC exosomes represents a novel strategy to enhance HCC chemosensitivity. -other hsa-mir-24 "Carcinoma, Pancreatic" 26517093 The miR-24-Bim pathway promotes tumor growth and angiogenesis in pancreatic carcinoma. -other hsa-mir-155 "Lymphoma, Large B-Cell, Diffuse" 26523117 "In particular, it has been strongly implicated in the causation of diffuse large B-cell lymphomas." -other hsa-mir-185 Atherosclerosis 26523989 "These findings reveal that miR-185 controls cholesterol homeostasis as a key posttranscriptional LDLR modulator in hepatic cells, providing novel insight into the regulatory mechanism for LDLR expression and the anti-atherosclerosis effect of miR-185-inhibitor." -other hsa-mir-21 Lung Neoplasms 26525579 "These results, demonstrating the function of exosomal miR-21 from transformed HBE cells, provide a new perspective for intervention strategies to prevent carcinogenesis of lung cancer." -other hsa-mir-200 "Carcinoma, Skin" 26527515 only a functionally coherent group consisting of the miR-200 family members and miR-205-5p displays a pattern of progressive co-downregulation from the early toward the most aggressive stages of carcinogenesis. -other hsa-mir-124 Glioma 26530859 "In conclusion,miR-124 was found to suppress the migration and invasion of glioma cells in vitro via Capn4." -other hsa-mir-4697 Gastric Neoplasms 26531872 "The expression of TM4SF5, CTD-2354A18.1 and miR-4697-3P is in balance at physiological conditions, however, the balance is disrupted by some situations, which may contribute to gastric cancer. GO analysis and Pathway analysis also showed TM4SF5 played an important role in proliferation,differentiation and apoptosis. Therefore, TM4SF5-miR-4697-3P- CTD-2354A18.1 may play a key role in the pathogenesis of gastric cancer (Tab. 2, Fig. 4, Ref. 30)." -other hsa-mir-210 Melanoma 26536104 "methyl sulfone decreased expression of the master regulator of hypoxia, HIF-1α, and reduced levels of the glycolytic enzymes, PKM2, LDHA, GLUT1, the pro-angiogenic protein, VEGF, and the iron-sulfur metabolism molecules, miR-210 and transferrin, all of which promote metastasis." -other hsa-mir-122 Hepatitis B Virus Infection 26541590 Mopping up miRNA: An integrated HBV transcript disrupts liver homeostasis by sequestering miR-122. -other hsa-mir-10b "Squamous Cell Carcinoma, Oral" 26544609 "Results from both patient groups together stress the importance of miR196a-5p in OSCC malignancy in both never and ever smokers, and emphasize the overall similarity of miRNA expression in OSCCs in these two risk groups. It implies that there may be great similarity in etiology of OSCC in never and ever smokers and that classifying OSCC based on tobacco exposure may not be helpful in the clinic." -other hsa-mir-196a "Squamous Cell Carcinoma, Oral" 26544609 "Results from both patient groups together stress the importance of miR196a-5p in OSCC malignancy in both never and ever smokers, and emphasize the overall similarity of miRNA expression in OSCCs in these two risk groups. It implies that there may be great similarity in etiology of OSCC in never and ever smokers and that classifying OSCC based on tobacco exposure may not be helpful in the clinic." -other hsa-mir-31 "Squamous Cell Carcinoma, Oral" 26544609 "Results from both patient groups together stress the importance of miR196a-5p in OSCC malignancy in both never and ever smokers, and emphasize the overall similarity of miRNA expression in OSCCs in these two risk groups. It implies that there may be great similarity in etiology of OSCC in never and ever smokers and that classifying OSCC based on tobacco exposure may not be helpful in the clinic." -other hsa-mir-125b Prostate Neoplasms 26544868 "Thus, the dual action of hsa-miR-125b as a tumor suppressor and hsa-miR-22 as an oncomiR contributed to prostate tumorigenesis by modulations in PI3K/AKT and MAPK/ERK signaling pathways, key pathways known to influence prostate cancer progression." -other hsa-mir-17 Neoplasms [unspecific] 26545119 "In summary, our data demonstrate that vFLIP and vCyclin induce the oncogenic miR-17-92 cluster in endothelial cells and thereby interfere with the TGF-¦Â signaling pathway. Manipulation of the TGF-¦Â pathway via host miRNAs represents a novel mechanism that may be important for KSHV tumorigenesis and angiogenesis, a hallmark of KS." -other hsa-mir-18 Neoplasms [unspecific] 26545119 "In summary, our data demonstrate that vFLIP and vCyclin induce the oncogenic miR-17-92 cluster in endothelial cells and thereby interfere with the TGF-¦Â signaling pathway. Manipulation of the TGF-¦Â pathway via host miRNAs represents a novel mechanism that may be important for KSHV tumorigenesis and angiogenesis, a hallmark of KS." -other hsa-mir-19a Neoplasms [unspecific] 26545119 "In summary, our data demonstrate that vFLIP and vCyclin induce the oncogenic miR-17-92 cluster in endothelial cells and thereby interfere with the TGF-¦Â signaling pathway. Manipulation of the TGF-¦Â pathway via host miRNAs represents a novel mechanism that may be important for KSHV tumorigenesis and angiogenesis, a hallmark of KS." -other hsa-mir-19b-1 Neoplasms [unspecific] 26545119 "In summary, our data demonstrate that vFLIP and vCyclin induce the oncogenic miR-17-92 cluster in endothelial cells and thereby interfere with the TGF-¦Â signaling pathway. Manipulation of the TGF-¦Â pathway via host miRNAs represents a novel mechanism that may be important for KSHV tumorigenesis and angiogenesis, a hallmark of KS." -other hsa-mir-20a Neoplasms [unspecific] 26545119 "In summary, our data demonstrate that vFLIP and vCyclin induce the oncogenic miR-17-92 cluster in endothelial cells and thereby interfere with the TGF-¦Â signaling pathway. Manipulation of the TGF-¦Â pathway via host miRNAs represents a novel mechanism that may be important for KSHV tumorigenesis and angiogenesis, a hallmark of KS." -other hsa-mir-92-1 Neoplasms [unspecific] 26545119 "In summary, our data demonstrate that vFLIP and vCyclin induce the oncogenic miR-17-92 cluster in endothelial cells and thereby interfere with the TGF-¦Â signaling pathway. Manipulation of the TGF-¦Â pathway via host miRNAs represents a novel mechanism that may be important for KSHV tumorigenesis and angiogenesis, a hallmark of KS." -other hsa-mir-155 Down Syndrome 26546125 "The lentiviral miRNA-sponge strategy demonstrated the genome-wide regulatory effects of miR-155 and miR-802. Furthermore, the analysis combining predicted candidates and experimental transcriptomic data proved to retrieve genes with potential significance in DS-hippocampal phenotype bridging with DS other neurological-associated diseases such as Alzheimer's disease." -other hsa-mir-802 Down Syndrome 26546125 "The lentiviral miRNA-sponge strategy demonstrated the genome-wide regulatory effects of miR-155 and miR-802. Furthermore, the analysis combining predicted candidates and experimental transcriptomic data proved to retrieve genes with potential significance in DS-hippocampal phenotype bridging with DS other neurological-associated diseases such as Alzheimer's disease." -other hsa-mir-200 Neoplasms [unspecific] 26547426 "On the basis of these findings,we believe that this method has great potential for quantitative detection of miRNA in biomedical research and early clinical diagnostics." -other hsa-mir-155 "Leukemia, Myelogenous, Chronic, BCR-ABL Positive" 26548770 Analysis of microRNA and gene networks in human chronic myelogenous leukemia. -other hsa-mir-146a Neoplasms [unspecific] 26549232 Together our results uncover miRNAs as yet another negative mechanism controlling Merlin tumor suppressor functions. -other hsa-mir-223 Prostate Neoplasms 26552919 "For the first time, we disclose that celastrol could induce miR-223 in breast and prostate cancer cells, and that inhibiting miR-223 could further reduce the living cells in celastrol-treated cancer cell lines. We thus provide a novel way to increase celastrol's anti-cancer effects." -other hsa-mir-218 Lung Neoplasms 26553452 Our findings revealed an integrative tumor suppressor function of miR-218 in lung carcinogenesis and metastasis. -other hsa-mir-340 Melanoma 26554847 "This is the first study showing the relationship between miR-340-5p and expression of ABCB5, a transmembrane transporter involved in drug resistance considered as a marker of melanoma stem-like cells." -other hsa-mir-7 "Carcinoma, Lung, Non-Small-Cell" 26557760 We found that miR-7 significantly decreased the IC50 of gefitinib and inhibited cell growth -other hsa-mir-34 Cardiovascular Diseases [unspecific] 26559089 MicroRNA-34 Family and Its Role in Cardiovascular Disease. -other hsa-mir-146a Psoriasis 26559308 "It is found that genetic polymorphisms related to some of specific miRNAs, miR-146a for example, are associated with psoriasis susceptibility." -other hsa-mir-21 Glioblastoma 26559642 Nanoparticle-Delivered Antisense MicroRNA-21 Enhances the Effects of Temozolomide on Glioblastoma Cells. -other hsa-mir-214 Multiple Sclerosis 26563334 "Our data suggest that miR-27a may probably inhibit negative regulators of Th17 cell differentiation, thus promoting its differentiation while miR-214 has an adverse effect." -other hsa-mir-27a Multiple Sclerosis 26563334 "Our data suggest that miR-27a may probably inhibit negative regulators of Th17 cell differentiation, thus promoting its differentiation while miR-214 has an adverse effect." -other hsa-mir-377 Myocardial Infarction 26564601 "The present study is timely because the field is eagerly awaiting the results of the large phase III BAMI (Bone Marrow-Derived Mononuclear Cells on All-Cause Mortality in Myocardial Infarction; NCT01569178) clinical trial. If this clinical trial turns out positively, approaches such as the one developed by Joladarashi et al. will have additional relevance to the field." -other hsa-mir-130 Pulmonary Hypertension 26565914 Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit. -other hsa-mir-301 Pulmonary Hypertension 26565914 Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit. -other hsa-mir-124 Atrial Fibrillation 26567235 "In conclusion, the microRNA regulatory network sheds new light on the molecular mechanism of AF with this non-coding regulated model." -other hsa-mir-183 Atrial Fibrillation 26567235 "In conclusion, the microRNA regulatory network sheds new light on the molecular mechanism of AF with this non-coding regulated model." -other hsa-mir-192 Atrial Fibrillation 26567235 "In conclusion, the microRNA regulatory network sheds new light on the molecular mechanism of AF with this non-coding regulated model." -other hsa-mir-215 Atrial Fibrillation 26567235 "In conclusion, the microRNA regulatory network sheds new light on the molecular mechanism of AF with this non-coding regulated model." -other hsa-mir-26b Atrial Fibrillation 26567235 "In conclusion, the microRNA regulatory network sheds new light on the molecular mechanism of AF with this non-coding regulated model." -other hsa-mir-355p Atrial Fibrillation 26567235 "In conclusion, the microRNA regulatory network sheds new light on the molecular mechanism of AF with this non-coding regulated model." -other hsa-mir-21 "Carcinoma, Nasopharyngeal" 26568302 LMP1 greatly increased expression of miR-21 and downregulated expression of the miR-21 target -other hsa-mir-218 Glioma 26572167 MiR-218-5p inhibits the stem cell properties and invasive ability of the A2B5+CD133- subgroup of human glioma stem cells. -other hsa-mir-21 "Carcinoma, Renal Cell, Clear-Cell" 26572589 "Thus, a single miRNA may have an impact on the formation of highly tumorigenic cancer spheres in kidney cancer." -other hsa-mir-148b Kidney Neoplasms 26573018 The present study therefore suggested that miR-148b exerts an oncogenic function by enhancing the proliferation and apoptosis of renal cancer cells by inhibiting the MAPK/JNK pathway. -other hsa-mir-122 Liver Diseases [unspecific] 26574140 "miR-122 increased with moderate ethanol consumption, but the fold change was modest. As increases with acetaminophen toxicity are 100- to 10000-fold, moderate ethanol intoxication is unlikely to confound the use of this biomarker of hepatotoxicity." -other hsa-mir-122 Schizophrenia 26575446 Circulating miRNA biomarkers for schizophrenia -other hsa-mir-130 Schizophrenia 26575446 Circulating miRNA biomarkers for schizophrenia -other hsa-mir-652 Schizophrenia 26575446 Circulating miRNA biomarkers for schizophrenia -other hsa-mir-145 Prostate Neoplasms 26582710 Re: A Feedback Regulation between miR-145 and DNA Methyltransferase 3b in Prostate Cancer Cell and Their Responses to Irradiation. -other hsa-mir-34a Vascular Disease [unspecific] 26582729 overexpression of a miR-34a mimic prevents metformin-mediated protection. -other hsa-mir-494 Atherosclerosis 26583674 Treatment with GSO-494 results in smaller atherosclerotic lesions with increased plaque stability. Inhibition of miR-494 may decrease the risk of surgical complications or even avert endarterectomy surgery in some cases. -other hsa-mir-122 Hepatitis C Virus Infection 26587035 characteristics of the miR-122 and Let-7 families further highlight the suitability of tree shrew as the animal model in HCV research. -other hsa-let-7 Ischemic Heart Disease 26588727 Computational Model of MicroRNA Control of HIF-VEGF Pathway: Insights into the Pathophysiology of Ischemic Vascular Disease and Cancer. -other hsa-mir-17 Perlman Syndrome 26598317 "Our findings not only provide a novel insight into the molecular mechanisms of macrosomia, but also the clinical value of miR-17-92 cluster as a predictive biomarker for macrosomia." -other hsa-mir-18 Perlman Syndrome 26598317 "Our findings not only provide a novel insight into the molecular mechanisms of macrosomia, but also the clinical value of miR-17-92 cluster as a predictive biomarker for macrosomia." -other hsa-mir-19a Perlman Syndrome 26598317 "Our findings not only provide a novel insight into the molecular mechanisms of macrosomia, but also the clinical value of miR-17-92 cluster as a predictive biomarker for macrosomia." -other hsa-mir-19b-1 Perlman Syndrome 26598317 "Our findings not only provide a novel insight into the molecular mechanisms of macrosomia, but also the clinical value of miR-17-92 cluster as a predictive biomarker for macrosomia." -other hsa-mir-20a Perlman Syndrome 26598317 "Our findings not only provide a novel insight into the molecular mechanisms of macrosomia, but also the clinical value of miR-17-92 cluster as a predictive biomarker for macrosomia." -other hsa-mir-92-1 Perlman Syndrome 26598317 "Our findings not only provide a novel insight into the molecular mechanisms of macrosomia, but also the clinical value of miR-17-92 cluster as a predictive biomarker for macrosomia." -other hsa-mir-150 "Squamous Cell Carcinoma, Esophageal" 26606907 "Taken together, our results highlight the involvement of miRNAs in ribosomal regulation during tumorigenesis." -other hsa-mir-383 "Squamous Cell Carcinoma, Esophageal" 26606907 "Taken together, our results highlight the involvement of miRNAs in ribosomal regulation during tumorigenesis." -other hsa-mir-190a "Carcinoma, Hepatocellular" 26608035 Our results reveal the involvement of miR-190a-treRNA axis in hepatoma progression and shed light on lncRNA-based cancer therapies for hepatoma patients at high risk of metastasis. -other hsa-mir-21 Neoplasms [unspecific] 26610525 induction of miR-21 by type I IFN -other hsa-mir-1 Bladder Outlet Obstruction 26612603 "We discuss known and predicted functions of miR-1, miR-29, miR-30, miR-132/212, miR-204 and miR-221, all of which change in BOO." -other hsa-mir-132 Bladder Outlet Obstruction 26612603 "We discuss known and predicted functions of miR-1, miR-29, miR-30, miR-132/212, miR-204 and miR-221, all of which change in BOO." -other hsa-mir-204 Bladder Outlet Obstruction 26612603 "We discuss known and predicted functions of miR-1, miR-29, miR-30, miR-132/212, miR-204 and miR-221, all of which change in BOO." -other hsa-mir-212 Bladder Outlet Obstruction 26612603 "We discuss known and predicted functions of miR-1, miR-29, miR-30, miR-132/212, miR-204 and miR-221, all of which change in BOO." -other hsa-mir-221 Bladder Outlet Obstruction 26612603 "We discuss known and predicted functions of miR-1, miR-29, miR-30, miR-132/212, miR-204 and miR-221, all of which change in BOO." -other hsa-mir-29 Bladder Outlet Obstruction 26612603 "We discuss known and predicted functions of miR-1, miR-29, miR-30, miR-132/212, miR-204 and miR-221, all of which change in BOO." -other hsa-mir-30 Bladder Outlet Obstruction 26612603 "We discuss known and predicted functions of miR-1, miR-29, miR-30, miR-132/212, miR-204 and miR-221, all of which change in BOO." -other hsa-mir-34a Ewing Sarcoma 26616853 CD99 counteracts EWS-FLI1 in controlling NF-¦ÊB signaling through the miR-34a -other hsa-mir-106b Colorectal Carcinoma 26617763 "Taken together, these findings demonstrated that miR-106b knockdown could induce EMT which conferring cells migratory and invasive properties but could not accomplish distant metastatic colonization efficiently." -other hsa-mir-506 "Carcinoma, Esophageal" 26617801 "Taken together, our data identify a new role of miR-506 in esophageal cancer involving CREB1 suppression." -other hsa-mir-223 "Carcinoma, Cervical" 26617846 "In conclusion, miR-223 inhibited cell metastasis of human cervical cancer by modulating epithelial-mesenchymal transition." -other hsa-mir-146a "Squamous Cell Carcinoma, Head and Neck" 26621153 Characterizing the expression of miR-146a and miR-155 and their functional role in tumor biology underlined significantly their proliferation and migration potential suggesting relevance as potential prognostic markers in HNSCC. -other hsa-mir-155 "Squamous Cell Carcinoma, Head and Neck" 26621153 Characterizing the expression of miR-146a and miR-155 and their functional role in tumor biology underlined significantly their proliferation and migration potential suggesting relevance as potential prognostic markers in HNSCC. -other hsa-mir-125a Neoplasms [unspecific] 26625740 This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage. -other hsa-mir-125b Neoplasms [unspecific] 26625740 This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage. -other hsa-mir-15a Neoplasms [unspecific] 26625740 This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage. -other hsa-mir-16-1 Neoplasms [unspecific] 26625740 This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage. -other hsa-mir-195 Neoplasms [unspecific] 26625740 This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage. -other hsa-mir-205 Neoplasms [unspecific] 26625740 This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage. -other hsa-mir-24-2 Neoplasms [unspecific] 26625740 This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage. -other hsa-mir-29 Neoplasms [unspecific] 26625740 This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage. -other hsa-mir-34a Neoplasms [unspecific] 26625740 This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage. -other hsa-mir-365-2 Neoplasms [unspecific] 26625740 This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage. -other hsa-mir-504 Neoplasms [unspecific] 26625740 This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage. -other hsa-let-7d Lung Neoplasms 26627242 "microRNA classifiers are powerful diagnostic/prognostic tools in ALK-, EGFR-, and KRAS-driven lung cancers." -other hsa-mir-769 Lung Neoplasms 26627242 "microRNA classifiers are powerful diagnostic/prognostic tools in ALK-, EGFR-, and KRAS-driven lung cancers." -other hsa-mir-138 "Adenocarcinoma, Lung" 26631041 we discovered that α-solanine could affect the expression of miR-138 and focal adhesion kinase -other hsa-mir-21 Graft-Versus-Host Disease 26631756 MicroRNA-21 deficiency protects from lupus-like autoimmunity in the chronic graft-versus-host disease model of systemic lupus erythematosus. -other hsa-mir-197 Gastric Neoplasms 26632693 Associations of Il-1 Family-Related Polymorphisms With Gastric Cancer Risk and the Role of Mir-197 In Il-1f5 Expression. -other hsa-mir-145 Diabetes Mellitus 26636106 "CRT may lead to left ventricular reverse remodeling, with LVEF, NYHA functional class, and 6MWT improvement in both diabetic and nondiabetic adult patients.These observations have been confirmed by other authors in a population of elderly diabetic patients, a part of 6MWT improvement, that is not CRT-induced in elderly diabetes." -other hsa-mir-26b Diabetes Mellitus 26636106 "CRT may lead to left ventricular reverse remodeling, with LVEF, NYHA functional class, and 6MWT improvement in both diabetic and nondiabetic adult patients.These observations have been confirmed by other authors in a population of elderly diabetic patients, a part of 6MWT improvement, that is not CRT-induced in elderly diabetes." -other hsa-mir-29a Diabetes Mellitus 26636106 "CRT may lead to left ventricular reverse remodeling, with LVEF, NYHA functional class, and 6MWT improvement in both diabetic and nondiabetic adult patients.These observations have been confirmed by other authors in a population of elderly diabetic patients, a part of 6MWT improvement, that is not CRT-induced in elderly diabetes." -other hsa-mir-92a Diabetes Mellitus 26636106 "CRT may lead to left ventricular reverse remodeling, with LVEF, NYHA functional class, and 6MWT improvement in both diabetic and nondiabetic adult patients.These observations have been confirmed by other authors in a population of elderly diabetic patients, a part of 6MWT improvement, that is not CRT-induced in elderly diabetes." -other hsa-mir-200c Lymphoma 26639163 Coordinated loss of microRNA group causes defenseless signaling in malignant lymphoma. -other hsa-mir-203 Lymphoma 26639163 Coordinated loss of microRNA group causes defenseless signaling in malignant lymphoma. -other hsa-mir-31 Lymphoma 26639163 Coordinated loss of microRNA group causes defenseless signaling in malignant lymphoma. -other hsa-mir-381 "Carcinoma, Lung, Non-Small-Cell" 26640150 ADAR1 overexpression enhances the editing frequencies of target transcripts such as NEIL1 and miR-381. -other hsa-mir-210 Ovarian Neoplasms 26640557 "miR-923, miR-1246, miR-149*, miR-638 and miR-210 were upregulated and miR-99a, miR-181a-2* and miR-339-5p were downregulated following bafilomycin A1 treatment." -other hsa-mir-127 Lymphoma 26640803 "The result of cross validation indicates that MiRNAClassify significantly outperforms other methods and models. In addition, the newly added pre-miRNAs are used to further evaluate the ability of these methods to discover novel pre-miRNAs. MiRNAClassify still achieves consistently superior performance and can discover more pre-miRNAs." -other hsa-mir-192 Breast Neoplasms 26642352 MiR-192-Mediated Positive Feedback Loop Controls the Robustness of Stress-Induced p53 Oscillations in Breast Cancer Cells. -other hsa-mir-485 Viral Infectious Disease 26645583 These findings highlight the dual role of miR-485 in preventing spurious activation of antiviral signaling and restricting influenza virus infection. -other hsa-mir-1307 Liver Neoplasms 26646011 Transcriptomic Analysis of Chronic Hepatitis B and C and Liver Cancer Reveals MicroRNA-Mediated Control of Cholesterol Synthesis Programs. -other hsa-mir-21 Liver Neoplasms 26646011 Transcriptomic Analysis of Chronic Hepatitis B and C and Liver Cancer Reveals MicroRNA-Mediated Control of Cholesterol Synthesis Programs. -other hsa-mir-224 Liver Neoplasms 26646011 Transcriptomic Analysis of Chronic Hepatitis B and C and Liver Cancer Reveals MicroRNA-Mediated Control of Cholesterol Synthesis Programs. -other hsa-mir-27 Liver Neoplasms 26646011 Transcriptomic Analysis of Chronic Hepatitis B and C and Liver Cancer Reveals MicroRNA-Mediated Control of Cholesterol Synthesis Programs. -other hsa-mir-33 Liver Neoplasms 26646011 Transcriptomic Analysis of Chronic Hepatitis B and C and Liver Cancer Reveals MicroRNA-Mediated Control of Cholesterol Synthesis Programs. -other hsa-mir-144 Allergic Asthma 26646558 "Together, the pathogenesis of OVA-induced asthma is highly associated with oxidative stress,and DAS may be an effective supplement to alleviate this disease." -other hsa-mir-34a Allergic Asthma 26646558 "Together, the pathogenesis of OVA-induced asthma is highly associated with oxidative stress,and DAS may be an effective supplement to alleviate this disease." -other hsa-mir-34b Allergic Asthma 26646558 "Together, the pathogenesis of OVA-induced asthma is highly associated with oxidative stress,and DAS may be an effective supplement to alleviate this disease." -other hsa-mir-335 Prostate Neoplasms 26647850 "These findings suggested that miR-335 and -543 are associated with bone metastasis of PCa and indicated that they may have important roles in the bone metastasis, which may also be clinically used as novel biomarkers in discriminating the different stages of human PCa and predicting bone metastasis." -other hsa-mir-543 Prostate Neoplasms 26647850 "These findings suggested that miR-335 and -543 are associated with bone metastasis of PCa and indicated that they may have important roles in the bone metastasis, which may also be clinically used as novel biomarkers in discriminating the different stages of human PCa and predicting bone metastasis." -other hsa-mir-122 Infertility 26648257 Altered miRNA Signature of Developing Germ-cells in Infertile Patients Relates to the Severity of Spermatogenic Failure and Persists in Spermatozoa. -other hsa-mir-34c Infertility 26648257 Altered miRNA Signature of Developing Germ-cells in Infertile Patients Relates to the Severity of Spermatogenic Failure and Persists in Spermatozoa. -other hsa-mir-449a Infertility 26648257 Altered miRNA Signature of Developing Germ-cells in Infertile Patients Relates to the Severity of Spermatogenic Failure and Persists in Spermatozoa. -other hsa-mir-34a Neoplasms [unspecific] 26648462 "MiR-34a is associated with G1 cell cycle arrest, senescence and apoptosis, thereby possessing a tumor suppressor activity." -other hsa-let-7g "Carcinoma, Esophageal" 26655271 BAG3-mediated miRNA let-7g and let-7i inhibit proliferation and enhance apoptosis of human esophageal carcinoma cells by targeting the drug transporter ABCC10. -other hsa-let-7i "Carcinoma, Esophageal" 26655271 BAG3-mediated miRNA let-7g and let-7i inhibit proliferation and enhance apoptosis of human esophageal carcinoma cells by targeting the drug transporter ABCC10. -other hsa-mir-122 "Carcinoma, Hepatocellular" 26655273 Our data imply that an intimate correlation between miR-122 and IGF-1R abnormal expression is a critical determinant of sorafenib tolerance. -other hsa-mir-124 Ovarian Neoplasms 26655797 A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression. -other hsa-mir-155 Ovarian Neoplasms 26655797 A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression. -other hsa-mir-181b Ovarian Neoplasms 26655797 A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression. -other hsa-mir-517a Ovarian Neoplasms 26655797 A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression. -other hsa-mir-323 Glioma 26656446 MiRNA-323-5p inhibited human cerebral glioma U373 cell proliferation and promoted its apoptosis by reducing IGF-1R. -other hsa-mir-122 Inflammation 26657215 "In addition to the classical Jak-Stat antiviral signaling pathway,IFN-¦Ë1 inhibits HCV replication through the suppression of miRNA-122 transcription via an inflammatory Stat 3-HNF4¦Á feedback loop. Inflammatory feedback circuits activated by IFNs during chronic inflammation expose non-responders to the risk of hepatocellular carcinoma." -other hsa-mir-17 Diabetes Mellitus 26660634 miR-17 repression mediates the pro-apoptotic effect of high glucose -other hsa-mir-372 "Adenocarcinoma, Prostate" 26662140 "hsa-miR-372 and miR-373, we suggest that miR-ch21 down-regulation might be the result of specific silencing of miR genes mapped to chromosome 21" -other hsa-mir-27a Breast Neoplasms 26662313 knockdown of miR-27a by the specific inhibitors significantly increased the sensitivity of T-47D cells to cisplatin (CDDP) treatment. -other hsa-mir-126 Atherosclerosis 26662986 "In particular, the specific roles of miR-126 and miR-143/145, master regulators of EC and VSMC function, respectively, are deeply explored." -other hsa-mir-423 "Carcinoma, Hepatocellular" 26663009 miR423-5p contributed to the tumorigenesis and progression of HCC.It could be a new predictor in HCC patients beyond the Milan criteria and would help to improve patient outcomes and enlarge recipient pools of liver transplantation. -other hsa-mir-122 Liver Diseases [unspecific] 26669080 Biological function of miR-122 and its relationship with liver diseases. -other hsa-mir-34c Colorectal Carcinoma 26674205 "Res suppressed CRC by specifically activating miR-34c-KITLG in vitro and in vivo; and the effect was strengthened in the presence of p53. Besides, Resexerted a synergistic effect with Oxa in a miR-34c dependent manner. We also suggested that Res-increased miR-34c could interfere IL-6-triggered CRC progression." -other hsa-mir-155 Autoimmune Diseases [unspecific] 26674874 We have shown that mice in which the miR-155 host gene (MIR155HG) has been deactivated are resistant to EAE. -other hsa-let-7 Hematologic Neoplasms 26676759 "Taken together, our results reveal a previously unknown mechanism by which Myc induces apoptosis independent of the p53 pathway and as a response to HDACi in malignant hematopoietic cells." -other hsa-mir-15 Hematologic Neoplasms 26676759 "Taken together, our results reveal a previously unknown mechanism by which Myc induces apoptosis independent of the p53 pathway and as a response to HDACi in malignant hematopoietic cells." -other hsa-let-7d Osteosarcoma 26679758 Let-7d miRNA Shows Both Antioncogenic and Oncogenic Functions in Osteosarcoma-Derived 3AB-OS Cancer Stem Cells. -other hsa-mir-203 "Carcinoma, Lung, Non-Small-Cell" 26683818 "Our results suggest that LASP-1, mediated by miR-203,has crucial functions in the proliferation, migration and invasion of NSCLC." -other hsa-mir-196a "Carcinoma, Pancreatic" 26683934 "MiRNA-196a level may be a promising prognostic marker of recurrence in resected PanNETs, although further experimental investigation would be required." -other hsa-mir-520g Brain Neoplasms 26687818 Tissue Factor Regulation by miR-520g in Primitive Neuronal Brain Tumor Cells: A Possible Link between Oncomirs and the Vascular Tumor Microenvironment. -other hsa-mir-373 Laryngeal Neoplasms 26688807 Association of Polymorphic Variants of miRNA Processing Genes with Larynx Cancer Risk in a Polish Population. -other hsa-mir-202 Multiple Myeloma 26689580 miR-202 over-expression sensitized MM cells to bortezomib (Bort) but less to Thalidomide (Thal) and dexamethasone (Dex). -other hsa-let-7a Melanoma 26693896 "Aberrant activation of some known miRNAs, e.g. let-7a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR-214, miR-221 and 222, has been recognised to be linked with melanoma-associated genes" -other hsa-mir-221 Melanoma 26693896 "Aberrant activation of some known miRNAs, e.g. let-7a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR-214, miR-221 and 222, has been recognised to be linked with melanoma-associated genes" -other hsa-mir-125b Alzheimer Disease 26694372 MicroRNA (miRNA) Signaling in the Human CNS in Sporadic Alzheimer's Disease (AD)-Novel and Unique Pathological Features. -other hsa-mir-146a Alzheimer Disease 26694372 MicroRNA (miRNA) Signaling in the Human CNS in Sporadic Alzheimer's Disease (AD)-Novel and Unique Pathological Features. -other hsa-mir-155 Alzheimer Disease 26694372 MicroRNA (miRNA) Signaling in the Human CNS in Sporadic Alzheimer's Disease (AD)-Novel and Unique Pathological Features. -other hsa-mir-34a Alzheimer Disease 26694372 MicroRNA (miRNA) Signaling in the Human CNS in Sporadic Alzheimer's Disease (AD)-Novel and Unique Pathological Features. -other hsa-mir-7 Alzheimer Disease 26694372 MicroRNA (miRNA) Signaling in the Human CNS in Sporadic Alzheimer's Disease (AD)-Novel and Unique Pathological Features. -other hsa-mir-9 Alzheimer Disease 26694372 MicroRNA (miRNA) Signaling in the Human CNS in Sporadic Alzheimer's Disease (AD)-Novel and Unique Pathological Features. -other hsa-mir-1246 "Carcinoma, Lung, Non-Small-Cell" 26711929 "Anti-miR-1246 and anti-miR-1290 suppressed proliferation, sphere-formation, colony formation and invasion of NSCLC.CSCs-associated miR-1246, or miR-1290 may be important in the invasion or metastasis of NSCLC." -other hsa-mir-1290 "Carcinoma, Lung, Non-Small-Cell" 26711929 "Anti-miR-1246 and anti-miR-1290 suppressed proliferation, sphere-formation, colony formation and invasion of NSCLC.CSCs-associated miR-1246, or miR-1290 may be important in the invasion or metastasis of NSCLC." -other hsa-mir-21 Colorectal Carcinoma 26712035 "miR-21 followed by miR-34, miR-200 and miR-215 are the most reported miRNAs to have roles in colon CSC regulation." -other hsa-mir-215 Colorectal Carcinoma 26712035 "miR-21 followed by miR-34, miR-200 and miR-215 are the most reported miRNAs to have roles in colon CSC regulation." -other hsa-mir-208b Acute Myocardial Infarction 26712201 none -other hsa-mir-21 Neoplasms [unspecific] 26716902 LIF induces miR-21 expression through the activation of STAT3. -other hsa-mir-34a Neoplasms [unspecific] 26718338 MicroRNA-34a Negatively Regulates Efferocytosis by Tissue Macrophages in Part via SIRT1. -other hsa-mir-29b Multiple Myeloma 26718793 genistein could suppress the protein level of NF-κB and promote the expression of miR-29b in U266 cells. -other hsa-mir-106a Gastric Neoplasms 26722506 Diagnostic significance of miR-106a in gastric cancer. -other hsa-mir-340 Gastric Neoplasms 26722508 Effect of miR-340 on gastric cancer cell proliferation and apoptosis. -other hsa-mir-141 Ovarian Neoplasms 26725650 "These mechanisms have significant relevance in ovarian cancers and stress response, pathophysiological conditions in which miR-200c/141 exert key functions." -other hsa-mir-200c Ovarian Neoplasms 26725650 "These mechanisms have significant relevance in ovarian cancers and stress response, pathophysiological conditions in which miR-200c/141 exert key functions." -other hsa-mir-149 "Leukemia, Lymphoblastic, Acute" 26725775 miRNA-149* promotes cell proliferation and suppresses apoptosis by mediating JunB in T-cell acute lymphoblastic leukemia. -other hsa-mir-146a "Colitis, Ulcerative" 26730791 "Our results suggest that microRNAs may serve as a novel regulator in function and homoeostasis of UC Treg cells, providing a key role for them in pathophysiology of UC." -other hsa-mir-155 "Colitis, Ulcerative" 26730791 "Our results suggest that microRNAs may serve as a novel regulator in function and homoeostasis of UC Treg cells, providing a key role for them in pathophysiology of UC." -other hsa-mir-21 "Colitis, Ulcerative" 26730791 "Our results suggest that microRNAs may serve as a novel regulator in function and homoeostasis of UC Treg cells, providing a key role for them in pathophysiology of UC." -other hsa-mir-125 Malignant Neoplasms [unspecific] 26731991 "These results suggest that different members of the miR-125 family may have different functions in various cancers. Furthermore, miR-125a or miR-125b may be important clinical prognostic biomarkers for cancer patients." -other hsa-mir-143 Inflammation 26739093 Staphylococcal LTA-Induced miR-143 Inhibits Propionibacterium acnes-Mediated Inflammatory Response in Skin -other hsa-mir-155 "Carcinoma, Colon" 26744471 MicroRNA-155 deletion promotes tumorigenesis in the azoxymethane-dextran sulfate sodium model of colon cancer. -other hsa-mir-25 "Leukemia, Myeloid, Acute" 26744876 "Moreover, miR-155 level was positively associated with the white blood cell (WBC) count, serum lactate dehydrogenase (LDH) and C-reaction protein (CRP) value in peripheral blood (PB), as well as miR-25/miR-196b expression levels." -other hsa-mir-34a Gastric Neoplasms 26745070 Our study demonstrates chrysin loaded PLGA-PEG promises a natural and efficient system for anticancer drug delivery to fight gastric cancer. -other hsa-mir-892b Breast Neoplasms 26747895 miR-892b Silencing Activates NF-¦ÊB and Promotes Aggressiveness in Breast Cancer. -other hsa-let-7b Melanoma 26754091 EGCG up-regulated miRNA-let-7b expression through 67LR in melanoma cells. -other hsa-mir-142 Melanoma 26763444 "Identification, Review, and Systematic Cross-Validation of microRNA Prognostic Signatures in Metastatic Melanoma." -other hsa-mir-146b Melanoma 26763444 "Identification, Review, and Systematic Cross-Validation of microRNA Prognostic Signatures in Metastatic Melanoma." -other hsa-mir-150 Melanoma 26763444 "Identification, Review, and Systematic Cross-Validation of microRNA Prognostic Signatures in Metastatic Melanoma." -other hsa-mir-155 Melanoma 26763444 "Identification, Review, and Systematic Cross-Validation of microRNA Prognostic Signatures in Metastatic Melanoma." -other hsa-mir-342 Melanoma 26763444 "Identification, Review, and Systematic Cross-Validation of microRNA Prognostic Signatures in Metastatic Melanoma." -other hsa-mir-106b "Carcinoma, Cervical" 26769181 Our data suggest that the TGF-¦Â1/miR-106b/DAB2 axis may be involved in the pathogenesis of cervical carcinoma. -other hsa-mir-21 Breast Neoplasms 26769851 "miR-21, a well-documented oncogenic miRNA for promoting tumor cell metastasis, was also found to be involved in inhibitory activity of SSA in breast tumor cell motility through the modulation of TGFβ pathway." -other hsa-mir-590 Diabetes Mellitus 26770982 "In this study, we identified a LDHA-suppressing microRNA (hsa-miR-590-3p)and used it together with human embryonic stem cell (hESC) derived pancreatic endoderm (PE) transplantation into a high-fat diet induced T2D mouse model. The procedure significantly improved glucose metabolism and other symptoms of T2D." -other hsa-mir-155 Neoplasms [unspecific] 26771315 Screening of Pre-miRNA-155 Binding Peptides for Apoptosis Inducing Activity Using Peptide Microarrays. -other hsa-mir-194 Aneurysm 26771601 "Aneurysm miRNA Signature Differs, Depending on Disease Localization and Morphology." -other hsa-mir-19b-1 Aneurysm 26771601 "Aneurysm miRNA Signature Differs, Depending on Disease Localization and Morphology." -other hsa-mir-21 Aneurysm 26771601 "Aneurysm miRNA Signature Differs, Depending on Disease Localization and Morphology." -other hsa-mir-362 Aneurysm 26771601 "Aneurysm miRNA Signature Differs, Depending on Disease Localization and Morphology." -other hsa-mir-550 Aneurysm 26771601 "Aneurysm miRNA Signature Differs, Depending on Disease Localization and Morphology." -other hsa-mir-769 Aneurysm 26771601 "Aneurysm miRNA Signature Differs, Depending on Disease Localization and Morphology." -other hsa-mir-18a Gastric Neoplasms 26772615 "Down regulation of miR-18a, miR-21 and miR-221 genes in gastric cancer cell line by chrysin-loaded PLGA-PEG nanoparticles." -other hsa-mir-21 Gastric Neoplasms 26772615 "Down regulation of miR-18a, miR-21 and miR-221 genes in gastric cancer cell line by chrysin-loaded PLGA-PEG nanoparticles." -other hsa-mir-221 Gastric Neoplasms 26772615 "Down regulation of miR-18a, miR-21 and miR-221 genes in gastric cancer cell line by chrysin-loaded PLGA-PEG nanoparticles." -other hsa-mir-29b "Carcinoma, Lung, Non-Small-Cell" 26776158 knockdown of ETS1 led to upregulation of eight microRNAs and downregulation of miR-29b in the immune-evasion subtype. -other hsa-mir-145 "Carcinoma, Lung, Non-Small-Cell" 26780934 TP53 knockdown reduced the miRNA hsa-miR-145 -other hsa-mir-34a "Squamous Cell Carcinoma, Esophageal" 26782413 Clinical significance of microRNA-34a in esophageal squamous cell carcinoma. -other hsa-mir-29a Colorectal Carcinoma 26782449 Diagnostic performance of microRNA-29a for colorectal cancer: a meta-analysis. -other hsa-mir-125b Ewing Sarcoma 26782555 Circulating miR-125b as a biomarker of Ewing's sarcoma in Chinese children. -other hsa-let-7d Idiopathic Pulmonary Fibrosis 26787543 Lin28B causes epithelial-mesenchymal transition (EMT) by inhibition of let-7d. -other hsa-mir-203 Breast Neoplasms 26790955 Kallistatin induces breast cancer cell apoptosis and autophagy by modulating Wnt signaling and microRNA synthesis. -other hsa-mir-21 Breast Neoplasms 26790955 Kallistatin induces breast cancer cell apoptosis and autophagy by modulating Wnt signaling and microRNA synthesis. -other hsa-mir-34a Breast Neoplasms 26790955 Kallistatin induces breast cancer cell apoptosis and autophagy by modulating Wnt signaling and microRNA synthesis. -other hsa-mir-132 Alzheimer Disease 26792551 MicroRNA-132 and early growth response-1 in nucleus basalis of Meynert during the course of Alzheimer's disease. -other hsa-mir-155 Breast Neoplasms 26795347 miR-155 Drives Metabolic Reprogramming of ER+ Breast Cancer Cells Following Long-Term Estrogen Deprivation and Predicts Clinical Response to Aromatase Inhibitors. -other hsa-mir-34c "Carcinoma, Nasopharyngeal" 26795575 Our study presents the current knowledge of miRNA regulatory network in NPC with combination of bioinformatics analysis and literature research. The hypothesis of miR-34c regulatory pathway may be beneficial in guiding further studies on the molecular mechanism of NPC tumorigenesis. -other hsa-mir-221 "Squamous Cell Carcinoma, Oral" 26796268 depleting cells of miR-221 increases the sensitivity of the cells to Adriamycin. -other hsa-mir-151a Hepatitis B Virus Infection 26801621 "We identified miR-24-3p, miR-151a-5p, and miR-425-5p as the most valid combination of reference genes for microRNA RT-qPCR studies in our hepatitis B virus replicating HepG2 cell model." -other hsa-mir-24 Hepatitis B Virus Infection 26801621 "We identified miR-24-3p, miR-151a-5p, and miR-425-5p as the most valid combination of reference genes for microRNA RT-qPCR studies in our hepatitis B virus replicating HepG2 cell model." -other hsa-mir-425 Hepatitis B Virus Infection 26801621 "We identified miR-24-3p, miR-151a-5p, and miR-425-5p as the most valid combination of reference genes for microRNA RT-qPCR studies in our hepatitis B virus replicating HepG2 cell model." -other hsa-mir-17 "Carcinoma, Hepatocellular" 26804174 "SLU7 knockdown altered the splicing of the C13orf25 primary transcript, and markedly reduced the expression of its miR-17, miR-20 and miR-92a constituents." -other hsa-mir-92a "Carcinoma, Hepatocellular" 26804174 "SLU7 knockdown altered the splicing of the C13orf25 primary transcript, and markedly reduced the expression of its miR-17, miR-20 and miR-92a constituents." -other hsa-mir-132 Chronic Obstructive Pulmonary Disease 26807508 "Ectopic expression of PKR or miR-132 antagomiR alone failed to restore IFN-β induction, whereas cotreatment increased antiviral stress granule formation, induction of p300, and IFN-β in COPD pBECs." -other hsa-mir-301a Prostate Neoplasms 26813459 "Taken together, we demonstrated that miR-301a/b-NDRG2 might be an important axis modulating autophagy and viability of prostate cancer cells under hypoxia." -other hsa-mir-301b Prostate Neoplasms 26813459 "Taken together, we demonstrated that miR-301a/b-NDRG2 might be an important axis modulating autophagy and viability of prostate cancer cells under hypoxia." -other hsa-mir-223 Pulmonary Hypertension 26815432 "Inhibition of miR-223 did not attenuate MCT PAH, whereas human prostacyclin synthase overexpression restored miRNA levels in MCT PAH to levels detected in naive rats. These data may establish a paradigm linking attenuation of PAH to restoration of BMPR2 signaling." -other hsa-mir-205 "Carcinoma, Endometrial" 26817318 The role of miRNA in endometrial cancer in the context of miRNA 205 -other hsa-mir-199 Ovarian Neoplasms 26819477 "miR-199a-5p and miR-34a-5p showed specific association with the disease, including molecular and cellular functions" -other hsa-mir-34a Ovarian Neoplasms 26819477 "miR-199a-5p and miR-34a-5p showed specific association with the disease, including molecular and cellular functions" -other hsa-mir-150 Sepsis 26822049 "Lower microRNA-150 may indicate a poor prognosis, and Picco monitoring combined with microRNA 150 detection may improve the prognostic efficiency in septic shock patients." -other hsa-mir-224 Colorectal Carcinoma 26822534 Our research showed mechanistic links between miR-224 and Wnt/¦Â-catenin in the pathogenesis of CRC through modulation of GSK3¦Â and SFRP2. -other hsa-mir-143 Colon Neoplasms 26824186 miR-143 or miR-145 overexpression increases cetuximab-mediated antibody-dependent cellular cytotoxicity in human colon cancer cells -other hsa-mir-145 Colon Neoplasms 26824186 miR-143 or miR-145 overexpression increases cetuximab-mediated antibody-dependent cellular cytotoxicity in human colon cancer cells -other hsa-mir-21 Diabetes Mellitus 26826461 Role of microRNA 21 in diabetes and associated/related diseases. -other hsa-mir-101 Pancreatic Neoplasms 26828016 MicroRNA-101-3p reverses gemcitabine resistance by inhibition of ribonucleotide reductase M1 in pancreatic cancer. -other hsa-mir-126 "Leukemia, Myeloid, Acute" 26832662 miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells. -other hsa-mir-200c "Squamous Cell Carcinoma, Oral" 26839311 "suppression of the anti-inflammatory tumor suppressor microRNAs let-7d, miR-23b, and miR-200c was observed following PAR-2 stimulation." -other hsa-mir-148a Prostate Neoplasms 26843836 "decreased expressions of tumor suppressors: miR-34a, miR-143, miR-148a and miR-200 family are involved in resistance of anti-cancer drugs" -other hsa-mir-29a Myocardial Ischemic-Reperfusion Injury 26844226 "After Myocardial Ischemia-Reperfusion, miR-29a, and Let7 Could Affect Apoptosis through Regulating IGF-1." -other hsa-mir-155 Liver Injury 26844784 Role of miR-155 in fluorooctane sulfonate-induced oxidative hepatic damage via the Nrf2-dependent pathway. -other hsa-mir-133a Cardiomegaly 26845040 APN reversed miR-133a levels through AMPK activation -other hsa-mir-145 Cardiovascular Diseases [unspecific] 26845891 THERAPEUTIC POTENTIAL OF MICRORNA IN THE FIELD OF CARDIOVASCULAR SURGERY. -other hsa-mir-122 Hepatitis C Virus Infection 26845923 Mechanism of regulation of HCV replication by miR-122. -other hsa-mir-216b "Carcinoma, Lung, Non-Small-Cell" 26852748 microRNA (miR)-216b levels were significantly downregulated in paclitaxel-treated NSCLC cells. -other hsa-mir-145 Bladder Neoplasms 26852750 decreasing miR-145 expression reduced cisplatin sensitivity -other hsa-mir-30d Heart Failure 26858295 "Letter by Sardu et al Regarding Article, Circulating MicroRNA-30d Is Associated With Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study." -other hsa-mir-30d Heart Failure 26858296 "Response to Letter Regarding Article, Circulating MicroRNA-30d Is Associated With Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study." -other hsa-mir-126 Leukemia 26859449 miR-126 Drives Quiescence and Self-Renewal in Leukemic Stem Cells. -other hsa-mir-205 "Squamous Cell Carcinoma, Cerevial" 26864590 ΔNp63α attenuates tumor aggressiveness by suppressing miR-205/ZEB1-mediated epithelial-mesenchymal transition in cervical squamous cell carcinoma. -other hsa-mir-92a "Leukemia, Myeloid" 26866730 The human myeloid leukemia cell line K562 secretes exosomes containing a large amount of miR-92a that enhances angiogenesis under normoxic and hypoxic conditions. -other hsa-mir-182 Prostate Neoplasms 26870290 "mangiferin inhibited proliferation and induced apoptosis in PC3 human prostate cancer cells, and this effect was correlated with downregulation of Bcl-2 and upregulation of miR-182." -other hsa-mir-31 Colorectal Carcinoma 26871294 "In conclusion, an inverse association was identified between EZH2 and miR-31 in colorectal cancers." -other hsa-mir-26b Melanoma 26872428 MiR-26b inhibits melanoma cell proliferation and enhances apoptosis by suppressing TRAF5-mediated MAPK activation. -other hsa-mir-144 Bronchiolitis Obliterans Syndrome 26874429 MicroRNA-144 is unlikely to play a role in bronchiolitis obliterans syndrome. -other hsa-mir-375 "Carcinoma, Merkel Cell" 26877261 Roles for miR-375 in Neuroendocrine Differentiation and Tumor Suppression via Notch Pathway Suppression in Merkel Cell Carcinoma. -other hsa-mir-193b "Carcinoma, Esophageal" 26878873 These results highlight the importance of miR-193b in determining oesophageal cancer cell viability and demonstrate an enhancement of chemotoxicity that is independent of apoptosis induction. -other hsa-mir-200c "Squamous Cell Carcinoma, Oral" 26879838 Sulforaphane treatment resulted in a dose-dependent increase in the levels of tumor suppressive miR200c. -other hsa-mir-141 "Carcinoma, Gastrooesophageal" 26885979 "The miRNA profile predictive for sensitivity to cisplatin,epirubicine and capecitabine was shown to be independently associated with OS and DSS in patients with gastrooesophageal cancer." -other hsa-mir-200c "Carcinoma, Gastrooesophageal" 26885979 "The miRNA profile predictive for sensitivity to cisplatin,epirubicine and capecitabine was shown to be independently associated with OS and DSS in patients with gastrooesophageal cancer." -other hsa-mir-505 "Carcinoma, Gastrooesophageal" 26885979 "The miRNA profile predictive for sensitivity to cisplatin,epirubicine and capecitabine was shown to be independently associated with OS and DSS in patients with gastrooesophageal cancer." -other hsa-mir-99b "Carcinoma, Gastrooesophageal" 26885979 "The miRNA profile predictive for sensitivity to cisplatin,epirubicine and capecitabine was shown to be independently associated with OS and DSS in patients with gastrooesophageal cancer." -other hsa-mir-196a-2 Breast Neoplasms 26886638 "The Associations of Single Nucleotide Polymorphisms in miR196a2, miR-499, and miR-608 With Breast Cancer Susceptibility: A STROBE-Compliant Observational Study." -other hsa-mir-499 Breast Neoplasms 26886638 "The Associations of Single Nucleotide Polymorphisms in miR196a2, miR-499, and miR-608 With Breast Cancer Susceptibility: A STROBE-Compliant Observational Study." -other hsa-mir-608 Breast Neoplasms 26886638 "The Associations of Single Nucleotide Polymorphisms in miR196a2, miR-499, and miR-608 With Breast Cancer Susceptibility: A STROBE-Compliant Observational Study." -other hsa-mir-15a "Lymphoma, Burkitt" 26893685 Correlation between the overexpression of Yin Yang 1 and the expression levels of miRNAs -other hsa-mir-134 Colorectal Carcinoma 26897940 Decreased Expression of MIR-134 and its Clinical Significance in Human Colorectal Cancer. -other hsa-mir-23b Diabetic Nephropathy 26898629 Diabetic nephropathy: MiR-23b protects against fibrosis in diabetic nephropathy. -other hsa-mir-155 "Adenocarcinoma, Lung" 26899325 Role of miR-155 in invasion and metastasis of lung adenocarcinoma A549 cells. -other hsa-mir-328 Neurodegenerative Diseases [unspecific] 26900752 "These experiments reveal Dicer1-miR-328-Bace1 signalling as a determinant of BAT function, and highlight the potential of Bace1 inhibition as a therapeutic approach to improve not only neurodegenerative diseases" -other hsa-mir-146a "Adenocarcinoma, Lung" 26902276 Effects of microRNA-146a on Fas-associated factor 2 and inflammatory factors in human lung adenocarcinoma A549 cells under the stimulation of cigarette smoke extract. -other hsa-mir-200 Ovarian Neoplasms 26910180 The prognostic value of the miR-200 family in ovarian cancer: a meta-analysis. -other hsa-mir-222 Melanoma 26912358 vesicles released by miR-222-overexpressing cells were able to transfer miR-222-dependent malignancy when taken-up by recipient primary melanomas. -other hsa-mir-150 Stroke 26922365 "Upregulation of miR-150 expression could decrease vascular density of infarct border zone in rat after MCAO and decrease tube formation, proliferation, and migration of BMVECs." -other hsa-mir-296 Neurofibromatosis type 2 26923924 Neurofibromatosis 2 (NF2) controls the invasiveness of glioblastoma through YAP-dependent expression of CYR61/CCN1 and miR-296-3p. -other hsa-let-7a Breast Neoplasms 26924493 "Mir-206 and let-7 were up-regulated, and mir-21 expression was down-regulated in the exercise training compared to tumor group." -other hsa-mir-21 Breast Neoplasms 26924493 "Mir-206 and let-7 were up-regulated, and mir-21 expression was down-regulated in the exercise training compared to tumor group." -other hsa-mir-126 Breast Neoplasms 26926567 MALAT1 induced migration and invasion of human breast cancer cells by competitively binding miR-1 with cdc42. -other hsa-mir-122 Hepatitis C Virus Infection 26927063 miR-125a-5p and miR-1231 have been shown to directly target hepatitis B virus (HBV) transcripts -other hsa-mir-33 Alzheimer Disease 26936997 Understanding the Role of miR-33 in Brain Lipid Metabolism: Implications for Alzheimer's Disease. -other hsa-mir-376 Breast Neoplasms 26940843 MIR376 as an important microRNA family for cancer formation and progression -other hsa-mir-376 Glioma 26940843 MIR376 as an important microRNA family for cancer formation and progression -other hsa-mir-376 Leukemia 26940843 MIR376 as an important microRNA family for cancer formation and progression -other hsa-mir-376 Ovarian Neoplasms 26940843 MIR376 as an important microRNA family for cancer formation and progression -other hsa-mir-21 Liver Cirrhosis 26946098 "increasing concentrations of Corilagin improved the quality of life, inhibited the mRNA expression of miR-21, promoted smad7 protein expression, and inhibited CTGF protein expression (p<0.05 or 0.01)." -other hsa-mir-203 "Squamous Cell Carcinoma, Tongue" 26946357 miR-203 inhibits cell proliferation and promotes cisplatin induced cell death in tongue squamous cancer. -other hsa-mir-370 "Diabetes Mellitus, Type 2" 26948318 salidroside can directly decrease the expression of miR-370 in type 2 diabetic mice -other hsa-mir-155 Rheumatoid Arthritis 26950427 epigenetic regulators such as micro-RNAs (i.e. miR-155) are key regulators of myeloid cells activation in RA -other hsa-mir-125b Inflammation 26954942 MiRNA-Mediated Macrophage Polarization and its Potential Role in the Regulation of Inflammatory Response. -other hsa-mir-146a Inflammation 26956852 Effect of High MiR-146a Expression on the Inflammatory Reaction in BV2 Cells. -other hsa-mir-221 Neoplasms [unspecific] 26959615 biological significance of miR-221/222 in a variety of malignancies indicates that they will play a crucial role in the future of innovative therapeutic strategies -other hsa-mir-222 Neoplasms [unspecific] 26959615 biological significance of miR-221/222 in a variety of malignancies indicates that they will play a crucial role in the future of innovative therapeutic strategies -other hsa-mir-375 Breast Neoplasms 26962366 Hsa-miR-375 is a predictor of local control in early stage breast cancer. -other hsa-mir-223 Obesity 26962854 High-Density Lipoprotein-Associated miR-223 Is Altered after Diet-Induced Weight Loss in Overweight and Obese Males. -other hsa-mir-24 Neoplasms [unspecific] 26967561 "melatonin can inhibit cell proliferation and migration, at least in part, by downregulating miR-24." -other hsa-mir-211 Colorectal Carcinoma 26974151 Long Non-Coding RNA ucoo2kmd.1 Regulates CD44-Dependent Cell Growth by Competing for miR-211-3p in Colorectal Cancer. -other hsa-mir-203 Prostate Neoplasms 26976978 increase of miR-203 expression after ZA exposure -other hsa-mir-10a Ovarian Disease 26979400 AFSC-derived exosomes prevent ovarian follicular atresia in CTx-treated mice via the delivery of microRNAs in which both miR-146a and miR-10a are highly enriched and their potential target genes are critical to apoptosis. -other hsa-mir-146a Pneumonia 26984146 "pneumococci recognition induces a negative feedback loop, preventing excessive inflammation via miR-146a and potentially other miRNAs." -other hsa-mir-143 Neoplasms [unspecific] 26988859 The miR-143/miR-145 cluster and the tumor microenvironment: unexpected roles. -other hsa-mir-145 Neoplasms [unspecific] 26988859 The miR-143/miR-145 cluster and the tumor microenvironment: unexpected roles. -other hsa-mir-17 "Lymphoma, Follicular" 26997445 miR-31 and miR-17-5p levels change during transformation of follicular lymphoma. -other hsa-mir-31 "Lymphoma, Follicular" 26997445 miR-31 and miR-17-5p levels change during transformation of follicular lymphoma. -other hsa-mir-503 Neoplasms [unspecific] 26999740 miRNA-503 Promotes Tumor Progression and Is Associated with Early Recurrence and Poor Prognosis in Human Colorectal Cancer. -other hsa-mir-29a "Carcinoma, Gastric" 27000664 Cell-derived microvesicles mediate the delivery of miR-29a/c to suppress angiogenesis in gastric carcinoma. -other hsa-mir-29c "Carcinoma, Gastric" 27000664 Cell-derived microvesicles mediate the delivery of miR-29a/c to suppress angiogenesis in gastric carcinoma. -other hsa-mir-20a Leukemia 27010069 "Mechanistic study further shows that induction of SIRPα protein in APL cells by ATO is mediated through suppression of c-Myc, resulting in reduction of three SIRPα-targeting microRNAs: miR-17, miR-20a and miR-106a." -other hsa-mir-146 "Carcinoma, Thyroid, Papillary" 27011326 Family of microRNA-146 Regulates RAR¦Â in Papillary Thyroid Carcinoma. -other hsa-mir-153 Breast Neoplasms 27012032 MicroRNA-153 Regulates NRF2 Expression and is Associated with Breast Carcinogenesis. -other hsa-mir-186 "Leukemia, Myeloid, Acute" 27012040 Down-Regulation of miR-186 Correlates with Poor Survival in de novo Acute Myeloid Leukemia. -other hsa-mir-30e Breast Neoplasms 27012041 Abnormal miRNA-30e Expression is Associated with Breast Cancer Progression. -other hsa-mir-140 Chordoma 27016303 "This study uncovered the potential of miR-31, miR-140-3p, miR-148a, and miR-222-3p to be key molecules in the cell viability, cell cycle, and apoptosis in chordomas, as well as initiation,differentiation, and progression." -other hsa-mir-148a Chordoma 27016303 "This study uncovered the potential of miR-31, miR-140-3p, miR-148a, and miR-222-3p to be key molecules in the cell viability, cell cycle, and apoptosis in chordomas, as well as initiation,differentiation, and progression." -other hsa-mir-222 Chordoma 27016303 "This study uncovered the potential of miR-31, miR-140-3p, miR-148a, and miR-222-3p to be key molecules in the cell viability, cell cycle, and apoptosis in chordomas, as well as initiation,differentiation, and progression." -other hsa-mir-210 "Carcinoma, Hepatocellular" 27018975 Down-regulation of TIMP2 by HIF-1α/miR-210/HIF-3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma. -other hsa-mir-139 Neoplasms [unspecific] 27022656 The loss of MiR-139-5p promotes colitis-associated tumorigenesis by mediating PI3K/AKT/Wnt signaling. -other hsa-mir-186 Alzheimer Disease 27029568 miR-186 in Alzheimer's disease: a big hope for a small RNA -other hsa-mir-221 Breast Neoplasms 27031715 "5-aza treatment caused an increase of miRNA-10b, -122, -200b levels in MCF-7/S cells, miRNA-34a, -10b, -122, -200b and -320a levels in MCF-7/Dox cells and miRNA-34a, -10b, -200b and -320a levels in MCF-7/DDP cells." -other hsa-mir-182 Keratitis 27035623 Inactivation of the miR-183/96/182 Cluster Decreases the Severity of Pseudomonas aeruginosa-Induced Keratitis. -other hsa-mir-183 Keratitis 27035623 Inactivation of the miR-183/96/182 Cluster Decreases the Severity of Pseudomonas aeruginosa-Induced Keratitis. -other hsa-mir-96 Keratitis 27035623 Inactivation of the miR-183/96/182 Cluster Decreases the Severity of Pseudomonas aeruginosa-Induced Keratitis. -other hsa-mir-126 Dengue Virus Infection 27039024 "GRP75 is involved in processing of host miRNA, hsa-mir-126, that down regulates dengue virus replication." -other hsa-mir-23b Neoplasms [unspecific] 27040799 Among down-regulators of PRODH/POX is an oncogenic transcription factor c-MYC and miR-23b*. -other hsa-mir-200 Glioma 27041571 SHP-2 acts together with PI3K/AKT to regulate a ZEB1-miR-200 feedback loop in PDGFRα-driven gliomas. -other hsa-mir-196a-2 Chronic Obstructive Pulmonary Disease 27043015 Association of MicroRNA-196a2 Variant with Response to Short-Acting ¦Â2-Agonist in COPD: An Egyptian Pilot Study. -other hsa-mir-92a "Lymphoma, Burkitt" 27044389 "Our results describe for the first time miR-17, miR-19a, miR-19b, miR-20a, and miR-92a expression profiles in pBL." -other hsa-mir-144 Bronchiolitis Obliterans Syndrome 27044533 MicroRNA-144 is unlikely to play a role in bronchiolitis obliterans syndrome. -other hsa-mir-3646 Breast Neoplasms 27045586 MicroRNA-3646 Contributes to Docetaxel Resistance in Human Breast Cancer Cells by GSK-3¦Â/¦Â-Catenin Signaling Pathway. -other hsa-mir-21 "Leukemia, Myelogenous, Chronic, BCR-ABL Positive" 27050372 Exosomes released by CML cells treated with Curcumin contain a high amount of miR-21 -other hsa-mir-16 Colorectal Carcinoma 27055667 Prodigiosin caused a significant increase in miRNA-16-1 expression -other hsa-mir-1 Myocardial Infarction 27056419 miR-1/133a control cardiac conductance and automaticity by regulating all phases of the cardiac action potential -other hsa-mir-1 Vascular Hypertrophy 27056419 miR-1/133a control cardiac conductance and automaticity by regulating all phases of the cardiac action potential -other hsa-mir-133a Vascular Hypertrophy 27056419 miR-1/133a control cardiac conductance and automaticity by regulating all phases of the cardiac action potential. -other hsa-mir-208 Vascular Hypertrophy 27056419 miR-208/499 located in introns of the heavy chain myosin genes regulate expression of sarcomeric contractile proteins. -other hsa-mir-499 Myocardial Infarction 27056419 miR-208/499 located in introns of the heavy chain myosin genes regulate expression of sarcomeric contractile proteins. -other hsa-mir-17 "Leukemia, Lymphocytic, Chronic, B-Cell" 27059597 "Interestingly, TLR1/2 triggering restored BCR functionality, likely breaching the anergic state, and this was accompanied by induction of the miR-17âˆ?2 cluster" -other hsa-mir-155 Pancreatic Neoplasms 27060060 "A vast number of miRNAs, including the well-studied miR-21, miR-155 and miR-34, has been shown to regulate PDAC growth, invasion and metastasis" -other hsa-mir-21 Pancreatic Neoplasms 27060060 "A vast number of miRNAs, including the well-studied miR-21, miR-155 and miR-34, has been shown to regulate PDAC growth, invasion and metastasis" -other hsa-mir-34 Pancreatic Neoplasms 27060060 "A vast number of miRNAs, including the well-studied miR-21, miR-155 and miR-34, has been shown to regulate PDAC growth, invasion and metastasis" -other hsa-mir-126 "Colitis, Ulcerative" 27061150 mango polyphenols attenuated inflammatory response by modulating the PI3K/AKT/mTOR pathway at least in part through upregulation of miRNA-126 expression both in vitro and in vivo -other hsa-let-7a Melanoma 27063098 two other miRNA modulators of EMT (miR-191 and let-7a) in serum exosomes -other hsa-let-7i Melanoma 27063098 two other miRNA modulators of EMT (miR-191 and let-7a) in serum exosomes -other hsa-mir-191 Melanoma 27063098 two other miRNA modulators of EMT (miR-191 and let-7a) in serum exosomes -other hsa-mir-146a Oral Lichen Planus 27063128 "Detection of miR-155, miR-146a in PBNCs and tissues from patients with oral lichen planus." -other hsa-mir-155 Oral Lichen Planus 27063128 "Detection of miR-155, miR-146a in PBNCs and tissues from patients with oral lichen planus." -other hsa-mir-663 Graft-Versus-Host Disease 27063175 Role of miR-663 in acute renal graft rejection: an in vitro study. -other hsa-mir-126 Thyroid Neoplasms 27067785 Interactive role of miR-126 on VEGF-A and progression of papillary and undifferentiated thyroid carcinoma. -other hsa-mir-182 "Carcinoma, Lung, Non-Small-Cell" 27073334 MiR-1244 sensitizes the resistance of non-small cell lung cancer A549 cell to cisplatin -other hsa-mir-21 Recurrent Wheezing 27075111 Extracellular microRNA-21 and microRNA-26a increase in body fluids from rats with antigen induced pulmonary inflammation and children with recurrent wheezing. -other hsa-mir-26a Recurrent Wheezing 27075111 Extracellular microRNA-21 and microRNA-26a increase in body fluids from rats with antigen induced pulmonary inflammation and children with recurrent wheezing. -other hsa-mir-155 "Adenocarcinoma, Lung" 27081085 "We identified a regulatory network including miR-15b and miR-155, and transcription factors with prognostic value in lung cancer." -other hsa-mir-31 Colorectal Carcinoma 27082577 MicroRNA Expression Signatures Associated With BRAF-Mutated Versus KRAS-Mutated Colorectal Cancers. -other hsa-mir-362 Colorectal Carcinoma 27082577 MicroRNA Expression Signatures Associated With BRAF-Mutated Versus KRAS-Mutated Colorectal Cancers. -other hsa-mir-425 Colorectal Carcinoma 27082577 MicroRNA Expression Signatures Associated With BRAF-Mutated Versus KRAS-Mutated Colorectal Cancers. -other hsa-mir-877 Colorectal Carcinoma 27082577 MicroRNA Expression Signatures Associated With BRAF-Mutated Versus KRAS-Mutated Colorectal Cancers. -other hsa-let-7c Neoplasms [unspecific] 27087117 microRNA let-7c (let-7c) contributed to the anisomycin-induced apoptosis -other hsa-mir-191 "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 27093985 Expression of microRNA-191 in T lymphoblastic leukemia/lymphoma and its underlying mechanism. -other hsa-mir-200c Neoplasms [unspecific] 27094812 "miR-200c, an illustrious tumor suppressor, is one of the highly studied miRNAs in terms of development, stemness, proliferation, epithelial-mesenchymal transition (EMT), therapy resistance, and metastasis." -other hsa-let-7 Neoplasms [unspecific] 27097729 The insights of Let-7 miRNAs in oncogenesis and stem cell potency. -other hsa-mir-206 Myocardial Infarction 27103465 "In an acute model of myocardial infarction, transplanted hypoxic MSCs showed a significantly improved survival as compared with hypoxic MSCs overexpressing miR-206." -other hsa-mir-21 Atherosclerosis 27107761 "LaCM decreased apoptosis, necrosis and inflammatory miR-155 and conversely increased anti-apoptotic miR-21 in Ec-LPS-treated HUVECs." -other hsa-mir-21 Liver Diseases [unspecific] 27107786 "In L-02 cells exposed to arsenite, microRNA-21 (miRNA-21) is over-expressed" -other hsa-mir-200b Retinal Degeneration 27113191 Effect of MiR-200b on retinal endothelial cell function in high-glucose condition and the mechanism. -other hsa-mir-221 Asthma 27113449 The degranulation was found to be significantly increased in miR-221 overexpressed cells while it was found to be significantly decreased in miR-221 downregulated cells. -other hsa-let-7a Liver Cirrhosis 27115285 There was decreased expression of let-7a in BDL and Mdr2(-/-) cholangiocytes that was associated with increased NGF expression. -other hsa-mir-124 Neurodegenerative Diseases [unspecific] 27117821 MicroRNAs underlying memory deficits in neurodegenerative disorders. -other hsa-mir-132 Neurodegenerative Diseases [unspecific] 27117821 MicroRNAs underlying memory deficits in neurodegenerative disorders. -other hsa-mir-34 Neurodegenerative Diseases [unspecific] 27117821 MicroRNAs underlying memory deficits in neurodegenerative disorders. -other hsa-mir-363 "Leukemia, Lymphocytic, Chronic, B-Cell" 27118451 Our results reveal an enrichment of specific cellular miRNAs including miR-363 within EVs derived from CD40/IL-4-stimulated CLL cells compared with parental cell miRNA content and control EVs from unstimulated CLL cells. -other hsa-mir-21 Acute Kidney Failure 27122240 "In summary, we report noninvasive detection of AKI in humans by combining the sensitivity of KIM-1 along with mechanistic potentials of miR-21, -200c, and -423." -other hsa-mir-200c "Carcinoma, Renal Cell, Clear-Cell" 27123083 "Aza-induced upregulation of miR-200c may inhibit migration, invasion and EMT in ccRCC cells." -other hsa-mir-17 Leukemia 27123834 Combinatorial treatment against miR-17-5p and miR-19a-3p of the miR-17-92 cluster dramatically reduces colony forming ability of MLL-fusion containing cell lines relative to non-MLL acute myeloid leukemia (AML) controls. -other hsa-mir-124 Stroke 27126323 lithium increased miR-124 expression -other hsa-mir-20a Multiple Myeloma 27129167 "Moreover, nano-sized exosomes were isolated with significantly increasing internal RNAs and down-regulation of exosomal miR-16-5p, miR-15a-5p and miR-20a-5p, miR-17-5p was revealed in the patients resistant to Bz." -other hsa-mir-425 Cardiovascular Diseases [unspecific] 27132035 "After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo" -other hsa-mir-425 Hypertension 27132035 "After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo" -other hsa-mir-425 Peripheral Vascular Disease 27132035 "After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo" -other hsa-mir-103 Diabetes Mellitus 27137869 Long-term treatment with 500 μM CML during adipogenesis resulted in increases in miR-103 and miR-143 levels -other hsa-mir-143 Diabetes Mellitus 27137869 Long-term treatment with 500 μM CML during adipogenesis resulted in increases in miR-103 and miR-143 levels -other hsa-mir-203 Gastric Neoplasms 27142767 Berberine modulates cisplatin sensitivity of human gastric cancer cells by upregulation of miR-203. -other hsa-mir-107 Alzheimer Disease 27143098 osthole plays a neuroprotective activity role in part through up-regulate miR-107 in AD. -other hsa-mir-34a "Leukemia, Lymphoblastic, Acute" 27150988 Expression of miR-34a in Bone Marrow of Adult Acute Lymphoblastic Leukemia and Its Significance in Cell Drug Resistance. -other hsa-mir-34c Bone Disease [unspecific] 27156573 Vaspin regulates the osteogenic differentiation of MC3T3-E1 through the PI3K-Akt/miR-34c loop. -other hsa-mir-16 Gastric Neoplasms 27157613 MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1. -other hsa-mir-21 Vascular Hypertrophy 27160852 Celastrol also inhibited the miR-21/ERK signalling pathway. -other hsa-mir-181a "Carcinoma, Thyroid, Papillary" 27164936 MiRNA-21 and MiRNA-181a-5p were found to be expressed reciprocally in the exosomes of patients with papillary and follicular TC -other hsa-mir-21 "Carcinoma, Thyroid, Papillary" 27164936 MiRNA-21 and MiRNA-181a-5p were found to be expressed reciprocally in the exosomes of patients with papillary and follicular TC -other hsa-mir-140 Arthritis 27165343 estrogen acts via ER and miR-140 to inhibit the catabolic activity of proteases within the chondrocyte extracellular matrix. -other hsa-mir-140 Osteoarthritis 27165343 estrogen acts via ER and miR-140 to inhibit the catabolic activity of proteases within the chondrocyte extracellular matrix. -other hsa-mir-489 Breast Neoplasms 27171498 miR-489 could reverse the chemoresistance of breast cancer via the PI3K-Akt pathway by targeting SPIN1. -other hsa-mir-139 Colorectal Carcinoma 27173050 miR-139-5p sensitizes colorectal cancer cells to 5-fluorouracil by targeting NOTCH-1. -other hsa-mir-451 Gastric Neoplasms 27173190 "Propofol effectively inhibited proliferation and induced apoptosis in gastric cancer cells, which was partly owing to the downregulation of MMP-2 expression by miR-451." -other hsa-mir-155 Colorectal Carcinoma 27176480 S100A8 activated the NF-κB pathway in the macrophages and promoted the expression of miR-155 -other hsa-mir-126 Heart Failure 27180261 miR-126 up-regulation activates EPCs and ECs and contributes to vascular healing and neovessel formation. -other hsa-mir-126 Myocardial Infarction 27180261 miR-126 up-regulation activates EPCs and ECs and contributes to vascular healing and neovessel formation. -other hsa-mir-494 Muscle Diseases [unspecific] 27181718 Effects of microRNA-494 on the fiber type-specific skeletal myogenesis in human induced pluripotent stem cells. -other hsa-mir-145 Vascular Disease [unspecific] 27186305 MicroRNA-145 regulates platelet-derived growth factor-induced human aortic vascular smooth muscle cell proliferation and migration by targeting CD40 -other hsa-mir-200 "Carcinoma, Lung" 27189341 AKT2 can regulate miR-200a in a histology- or stage-specific manner -other hsa-mir-200a "Carcinoma, Lung" 27189341 AKT2 can regulate miR-200a in a histology- or stage-specific manner and that -other hsa-mir-122 "Carcinoma, Hepatocellular" 27194671 High expression levels of plasma miR-122 are associated with early TACE refractoriness in HCC patients treated with TACE. -other hsa-mir-29b "Carcinoma, Lung, Non-Small-Cell" 27199349 "Overall, our results reveal a complexity in cancer for miR-29b, which can act as either an oncogene or tumor suppressor gene depending on signaling context." -other hsa-mir-4505 Oral Neoplasms 27207653 a microRNA (miR) analysis revealed that LCN2 can suppress CAIX expression and cell migration through miR-4505 induction. -other hsa-mir-92a Cardiovascular Diseases [unspecific] 27208561 PDW/miR-92a-score with a specificity of 97.5% and a sensitivity of 80.0% in relation to detect aspirin resistance. -other hsa-mir-497 Cerebral Ischemia 27209189 "amikacin inhibits miR-497 maturation and promotes ischemic neuronal survival by upregulating anti-apoptotic protein, bcl-2." -other hsa-mir-494 Breast Neoplasms 27216190 Elevating Dicer expression increased levels of the AXL kinase targeting miRNA miR-494 -other hsa-mir-126 Diabetic Retinopathy 27225425 MicroRNA-126 (miR-126) plays a potential role in the pathogenesis in DR -other hsa-mir-203 Colorectal Carcinoma 27236538 overexpression of miR-203 sensitizes colon cancer cells -other hsa-mir-20a Glioma 27242439 The expression levels of miR-20a decreased significantly after U-87 and U-251 cells were treated with EMAP-II. -other hsa-mir-92a Liver Cirrhosis 27246196 miR-92a expression closely correlated with the frequency of a subset of IL-17-producing T helper cells (Th17) -other hsa-mir-181a Ovarian Neoplasms 27249598 miR-181a overexpression decreased the PTX sensitivity of SKOV3 cells and while miR-181a inhibition increased the sensitivity of SKOV3/PTX cells. -other hsa-mir-449a Prostate Neoplasms 27250340 Overexpression of miR-449a or knockdown of c-Myc promoted the sensitivity of LNCaP cells to IR. -other hsa-mir-27b Chondrosarcoma 27252405 Adiponectin promotes VEGF-C-dependent lymphangiogenesis by inhibiting miR-27b through a CaMKII/AMPK/p38 signaling pathway in human chondrosarcoma cells -other hsa-mir-146a Inflammation 27256622 These effects were partially mediated through RvD2 induction of microRNA-146a -other hsa-mir-200 Breast Neoplasms 27257068 "miR-200 levels increase following hPMR1 knockdown, and changes in miR-200 family microRNAs were matched by corresponding changes in miR-200 targets and reporter expression." -other hsa-mir-30e Schizophrenia 27258654 miRNA-30e is associated with cognitive impairment in schizophrenia and depression. -other hsa-mir-30 "Adenocarcinoma, Colon" 27261459 miR-30 family likely plays an important role in IEC homeostasis -other hsa-mir-182 "Carcinoma, Hepatocellular" 27262453 "Upon forcing miR-182 expression in the HCC NK-cells, upregulation of both receptors was observed." -other hsa-mir-152 "Carcinoma, Endometrial" 27263284 Effect of Progesterone-induced MicroRNA-152 on the Proliferation of Endometrial Epithelial Cells. -other hsa-mir-4496 Gastric Neoplasms 27265143 "Here, we show that rebamipide suppresses H. pylori CagA-induced β-catenin and its target cancer-initiating cells (C-IC) marker gene expression via upregulation of miRNA-320a and -4496." -other hsa-mir-379 "Carcinoma, Hepatocellular" 27266355 "Effects of microRNA-379-5p on proliferation, migration and invasion of hepatocellular carcinoma cell line." -other hsa-mir-21 Lung Neoplasms 27266356 The effect and mechanism of microRNA-21 on cis-dichlorodiamineplatinum resistance in lung cancer cell strain. -other hsa-mir-34a Glioma 27268916 miR-34a was downregulated under hypoxia but upregulated by resveratrol -other hsa-mir-21 Autoimmune Diseases [unspecific] 27271606 miR-21 was found to be correlated with the pathogenesis of autoimmune diseases -other hsa-mir-146b Prostate Neoplasms 27273955 MicroRNA-146b acts as a potential tumor suppressor in human prostate cancer. -other hsa-mir-141 Prostate Neoplasms 27278879 "hub hsa-miR3176, -141-3p, -5004-5p, -16-5p, -3915, -488â€?p, -23c, -3673 and -3654 were potential targets to hub gene androgen receptor (AR) and phosphatase and tensin homolog (PTEN)." -other hsa-mir-16 Prostate Neoplasms 27278879 "hub hsa-miR3176, -141-3p, -5004-5p, -16-5p, -3915, -488â€?p, -23c, -3673 and -3654 were potential targets to hub gene androgen receptor (AR) and phosphatase and tensin homolog (PTEN)." -other hsa-mir-23c Prostate Neoplasms 27278879 "hub hsa-miR3176, -141-3p, -5004-5p, -16-5p, -3915, -488â€?p, -23c, -3673 and -3654 were potential targets to hub gene androgen receptor (AR) and phosphatase and tensin homolog (PTEN)." -other hsa-mir-3176 Prostate Neoplasms 27278879 "hub hsa-miR3176, -141-3p, -5004-5p, -16-5p, -3915, -488â€?p, -23c, -3673 and -3654 were potential targets to hub gene androgen receptor (AR) and phosphatase and tensin homolog (PTEN)." -other hsa-mir-32 Prostate Neoplasms 27278879 "hub hsa-miR3176, -141-3p, -5004-5p, -16-5p, -3915, -488â€?p, -23c, -3673 and -3654 were potential targets to hub gene androgen receptor (AR) and phosphatase and tensin homolog (PTEN)." -other hsa-mir-3654 Prostate Neoplasms 27278879 "hub hsa-miR3176, -141-3p, -5004-5p, -16-5p, -3915, -488â€?p, -23c, -3673 and -3654 were potential targets to hub gene androgen receptor (AR) and phosphatase and tensin homolog (PTEN)." -other hsa-mir-3673 Prostate Neoplasms 27278879 "hub hsa-miR3176, -141-3p, -5004-5p, -16-5p, -3915, -488â€?p, -23c, -3673 and -3654 were potential targets to hub gene androgen receptor (AR) and phosphatase and tensin homolog (PTEN)." -other hsa-mir-381 Prostate Neoplasms 27278879 "hub hsa-miR3176, -141-3p, -5004-5p, -16-5p, -3915, -488â€?p, -23c, -3673 and -3654 were potential targets to hub gene androgen receptor (AR) and phosphatase and tensin homolog (PTEN)." -other hsa-mir-3915 Prostate Neoplasms 27278879 "hub hsa-miR3176, -141-3p, -5004-5p, -16-5p, -3915, -488â€?p, -23c, -3673 and -3654 were potential targets to hub gene androgen receptor (AR) and phosphatase and tensin homolog (PTEN)." -other hsa-mir-429 Prostate Neoplasms 27278879 "hub hsa-miR3176, -141-3p, -5004-5p, -16-5p, -3915, -488â€?p, -23c, -3673 and -3654 were potential targets to hub gene androgen receptor (AR) and phosphatase and tensin homolog (PTEN)." -other hsa-mir-488 Prostate Neoplasms 27278879 "hub hsa-miR3176, -141-3p, -5004-5p, -16-5p, -3915, -488â€?p, -23c, -3673 and -3654 were potential targets to hub gene androgen receptor (AR) and phosphatase and tensin homolog (PTEN)." -other hsa-mir-5004 Prostate Neoplasms 27278879 "hub hsa-miR3176, -141-3p, -5004-5p, -16-5p, -3915, -488â€?p, -23c, -3673 and -3654 were potential targets to hub gene androgen receptor (AR) and phosphatase and tensin homolog (PTEN)." -other hsa-mir-606 Prostate Neoplasms 27278879 "hub hsa-miR3176, -141-3p, -5004-5p, -16-5p, -3915, -488â€?p, -23c, -3673 and -3654 were potential targets to hub gene androgen receptor (AR) and phosphatase and tensin homolog (PTEN)." -other hsa-mir-206 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 27279635 co-transfection of miR-375 and miR-206 exhibited a less effective inhibitory effect -other hsa-mir-221 Intrahepatic Cholangiocarcinoma 27280413 no correlation was found between the expression levels of these molecular markers and histopathological differentiation grade. -other hsa-mir-15a "Leukemia, Lymphoblastic, Acute" 27281445 Prednisolone in concentration of 700 ?M was significantly increased the expression of miR 16-1 and miR 15a after 24 h and 48 h treatment -other hsa-mir-16 "Leukemia, Lymphoblastic, Acute" 27281445 Prednisolone in concentration of 700 ?M was significantly increased the expression of miR 16-1 and miR 15a after 24 h and 48 h treatment -other hsa-mir-1 Neoplasms [unspecific] 27286699 miR-1 is classified to be a tumor suppressor -other hsa-mir-21 Heart Failure 27292200 heart failure (miR-21 and miR-133a) -other hsa-mir-146a Infection [unspecific] 27297392 miR-146a was found to be differentially regulated in THP-1 cells between probiotic and pathogenic bacteria. -other hsa-mir-410 Blindness 27297412 antisense microRNA-410 (anti-miR-410) induces RPE differentiation from amniotic epithelial stem cells. -other hsa-let-7d Lymphoma 27300436 "ΔNp63 inhibition decreases the levels of its transcriptional target, DGCR8, and the maturation of let-7d and miR-128" -other hsa-mir-128 Lymphoma 27300436 "ΔNp63 inhibition decreases the levels of its transcriptional target, DGCR8, and the maturation of let-7d and miR-128" -other hsa-mir-30a Breast Neoplasms 27302063 regulation of lumen formation by miR-342 -other hsa-mir-122 Hepatitis C Virus Infection 27303683 HCV infection requires miR-122 -other hsa-mir-125b Prostate Neoplasms 27305142 MiRNAs were shown to be differently distributed between different fractions of extracellular vesicles. -other hsa-mir-16 Prostate Neoplasms 27305142 MiRNAs were shown to be differently distributed between different fractions of extracellular vesicles. -other hsa-mir-19b Prostate Neoplasms 27305142 MiRNAs were shown to be differently distributed between different fractions of extracellular vesicles. -other hsa-mir-205 Prostate Neoplasms 27305142 MiRNAs were shown to be differently distributed between different fractions of extracellular vesicles. -other hsa-mir-25 Prostate Neoplasms 27305142 MiRNAs were shown to be differently distributed between different fractions of extracellular vesicles. -other hsa-let-7 "Carcinoma, Thyroid, Papillary" 27314338 "let-7 miRNA was found to reduce RAS levels, acting as a tumor suppressor gene." -other hsa-mir-125b Neoplasms [unspecific] 27321180 Forced expression of hsa-miR-125b in these cells resulted in radiosensitivity -other hsa-mir-128 Breast Neoplasms 27322220 miR-128 in exosomes negatively regulates the level of Bax in MCF-7 recipient cells and inhibits cell proliferation. -other hsa-mir-29b Bladder Neoplasms 27322434 miR-21 and miR-29b depression have been shown in Snail-1 suppressed group in EJ-138 cells in vitro. -other hsa-mir-27b Chondrosarcoma 27345723 expression of microRNA-27b was negatively regulated by leptin -other hsa-mir-21 Colorectal Carcinoma 27349026 Plasma Expression Levels of Circulating miR-21 are not Useful for Diagnosing and Monitoring Colorectal Cancer. -other hsa-mir-1 Gastric Neoplasms 27349337 "miR-1, -133 and -206 family in GC" -other hsa-mir-133 Gastric Neoplasms 27349337 "miR-1, -133 and -206 family in GC" -other hsa-mir-206 Gastric Neoplasms 27349337 "miR-1, -133 and -206 family in GC" -other hsa-mir-1 Ovarian Neoplasms 27354590 loss of growth-inhibitory functionality of miR-1 -other hsa-mir-141 Kidney Neoplasms 27358122 Invasion and metastasis ability of renal cancer cell strains 786-0: under the influence of miR-141. -other hsa-mir-210 Cardiovascular Diseases [unspecific] 27359286 "miR-210 has also been shown to be associated with the development of different human diseases including various types of cancers, cardiovascular and cerebrovascular diseases, and immunological diseases." -other hsa-mir-122 Hepatitis C Virus Infection 27366906 Hepatitis C Virus Core Protein Promotes miR-122 Destabilization by Inhibiting GLD-2. -other hsa-mir-21 Squamous Cell Carcinoma 27371785 Blueberry also modulated the expression of the oncomiR miR-21 and the tumor suppressor let-7. -other hsa-mir-21 Breast Neoplasms 27372573 "MCF-7 has a high level of miR-21, miR-375, and miR-27a as target miRNAs." -other hsa-mir-27a Breast Neoplasms 27372573 "MCF-7 has a high level of miR-21, miR-375, and miR-27a as target miRNAs." -other hsa-mir-375 Breast Neoplasms 27372573 "MCF-7 has a high level of miR-21, miR-375, and miR-27a as target miRNAs." -other hsa-mir-132 Neuroblastoma 27374124 New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins. -other hsa-mir-212 Neuroblastoma 27374124 New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins. -other hsa-mir-25 Neuroblastoma 27374124 New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins. -other hsa-mir-132 Inflammation 27378528 LPS down-regulated the expression of miRNA-132. -other hsa-mir-34a Alzheimer Disease 27378912 Over-Expressed Pathogenic miRNAs in Alzheimer's Disease (AD) and Prion Disease (PrD) Drive Deficits in TREM2-Mediated A¦Â42 Peptide Clearance. -other hsa-let-7 Neuroblastoma 27383785 Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma. -other hsa-mir-19 Schizophrenia 27387650 Our study demonstrates the significance of posttranscriptional gene regulation by miR-19 in preventing the irregular migration of adult-born neurons that may contribute to the etiology of schizophrenia. -other hsa-mir-125b Wound Healing 27388239 "the uMSC-exosomal microRNAs were examined by high-throughput sequencing, with a group of specific microRNAs (miR-21, miR-23a, miR-125b, and miR-145) found to play key roles in suppressing myofibroblast formation by inhibiting excess α-smooth muscle actin and collagen deposition associated with activity of the transforming growth factor-β/SMAD2 signaling pathway." -other hsa-mir-145 Wound Healing 27388239 "the uMSC-exosomal microRNAs were examined by high-throughput sequencing, with a group of specific microRNAs (miR-21, miR-23a, miR-125b, and miR-145) found to play key roles in suppressing myofibroblast formation by inhibiting excess α-smooth muscle actin and collagen deposition associated with activity of the transforming growth factor-β/SMAD2 signaling pathway." -other hsa-mir-21 Wound Healing 27388239 "the uMSC-exosomal microRNAs were examined by high-throughput sequencing, with a group of specific microRNAs (miR-21, miR-23a, miR-125b, and miR-145) found to play key roles in suppressing myofibroblast formation by inhibiting excess α-smooth muscle actin and collagen deposition associated with activity of the transforming growth factor-β/SMAD2 signaling pathway." -other hsa-mir-23a Wound Healing 27388239 "the uMSC-exosomal microRNAs were examined by high-throughput sequencing, with a group of specific microRNAs (miR-21, miR-23a, miR-125b, and miR-145) found to play key roles in suppressing myofibroblast formation by inhibiting excess α-smooth muscle actin and collagen deposition associated with activity of the transforming growth factor-β/SMAD2 signaling pathway." -other hsa-mir-18a Wound Healing 27390086 "We found miR-18a was most susceptible to SH treatment, the target prediction of which were enriched in a bunch of pathways implicated in corneal wound healing." -other hsa-mir-122 "Carcinoma, Hepatocellular" 27391076 "we showed that the isomiR profiles of liver specific MiR122, and a few other miRNAs, correlated with MC-LR treatment." -other hsa-mir-122 Liver Cirrhosis 27391076 "we showed that the isomiR profiles of liver specific MiR122, and a few other miRNAs, correlated with MC-LR treatment." -other hsa-mir-122 Liver Diseases [unspecific] 27391076 "we showed that the isomiR profiles of liver specific MiR122, and a few other miRNAs, correlated with MC-LR treatment." -other hsa-mir-95 Colorectal Carcinoma 27393650 "In conclusion, calycosin exerts an inhibitory effect on proliferation of CRC cells in vivo and in vitro, through ERβ-mediated regulation of the IGF-1R, PI3K/Akt signaling pathways and of miR-95 expression." -other hsa-mir-9 Alzheimer Disease 27394443 These results demonstrated that osthole plays a neuroprotective activity role in part through upregulating miR-9 in AD. -other hsa-mir-17 Neuroblastoma 27396325 "Here, we demonstrate that this microRNA (miRNA) cluster selectively targets several members of the nuclear hormone receptor (NHR) superfamily, and we present a unique NHR signature associated with the survival of neuroblastoma patients." -other hsa-mir-518a Atrioventricular Septal Defect 27396555 "Furthermore, miRNA-DEG regulatory networks were constructed. IL1B was the hub-gene of PPI networks, and AUTS2 and KIAA2022 were predicted to be targeted by miR-518a, miR518e, miR-518f, miR-528a, and miR-96.IL1B, IL12RB2, AUTS2, and KIAA2022 might participate in AVSD in DS patients, and AUTS2 and KIAA2022 might be targeted by miR-518a, miR-518e, miR-518f, miR-528a, and miR-96." -other hsa-mir-518e Atrioventricular Septal Defect 27396555 "Furthermore, miRNA-DEG regulatory networks were constructed. IL1B was the hub-gene of PPI networks, and AUTS2 and KIAA2022 were predicted to be targeted by miR-518a, miR518e, miR-518f, miR-528a, and miR-96.IL1B, IL12RB2, AUTS2, and KIAA2022 might participate in AVSD in DS patients, and AUTS2 and KIAA2022 might be targeted by miR-518a, miR-518e, miR-518f, miR-528a, and miR-96." -other hsa-mir-518f Atrioventricular Septal Defect 27396555 "Furthermore, miRNA-DEG regulatory networks were constructed. IL1B was the hub-gene of PPI networks, and AUTS2 and KIAA2022 were predicted to be targeted by miR-518a, miR518e, miR-518f, miR-528a, and miR-96.IL1B, IL12RB2, AUTS2, and KIAA2022 might participate in AVSD in DS patients, and AUTS2 and KIAA2022 might be targeted by miR-518a, miR-518e, miR-518f, miR-528a, and miR-96." -other hsa-mir-528a Atrioventricular Septal Defect 27396555 "Furthermore, miRNA-DEG regulatory networks were constructed. IL1B was the hub-gene of PPI networks, and AUTS2 and KIAA2022 were predicted to be targeted by miR-518a, miR518e, miR-518f, miR-528a, and miR-96.IL1B, IL12RB2, AUTS2, and KIAA2022 might participate in AVSD in DS patients, and AUTS2 and KIAA2022 might be targeted by miR-518a, miR-518e, miR-518f, miR-528a, and miR-96." -other hsa-mir-96 Atrioventricular Septal Defect 27396555 "Furthermore, miRNA-DEG regulatory networks were constructed. IL1B was the hub-gene of PPI networks, and AUTS2 and KIAA2022 were predicted to be targeted by miR-518a, miR518e, miR-518f, miR-528a, and miR-96.IL1B, IL12RB2, AUTS2, and KIAA2022 might participate in AVSD in DS patients, and AUTS2 and KIAA2022 might be targeted by miR-518a, miR-518e, miR-518f, miR-528a, and miR-96." -other hsa-mir-200a "Carcinoma, Lung, Non-Small-Cell" 27396618 we show that down-regulating Zeb-1 by inducing miR-200a or β-Catenin siRNA can increase drug sensitivity of TKI-resistant cells. -other hsa-mir-494 Retinoblastoma 27399693 "The overexpression of miR-494-3p in SAS cells increased the population of senescence-associated β-galactosidase positive cells, the expression of p16(INK4a) and retinoblastoma 1 (RB1), as well as downregulated Bmi1." -other hsa-mir-494 "Squamous Cell Carcinoma, Oral" 27399693 "The overexpression of miR-494-3p in SAS cells increased the population of senescence-associated β-galactosidase positive cells, the expression of p16(INK4a) and retinoblastoma 1 (RB1), as well as downregulated Bmi1." -other hsa-mir-17 Pancreatic Neoplasms 27400681 "Mechanically, we discovered that high GFRα2 expression level leads to PTEN inactivation via enhancing Mir-17-5p level." -other hsa-mir-9 Osteoarthritis 27404795 IL-6 expression is achieved through increased recruitment of CEBPα to the MCPIP1 promoter and by relieving the miR-9-mediated inhibition of MCPIP1 expression in OA chondrocytes. -other hsa-mir-31 Psoriasis 27405090 Its own regulation is disrupted during the onset and progression of cancer and autoimmune disorders such as psoriasis and systemic lupus erythematosus. -other hsa-mir-31 Systemic Lupus Erythematosus 27405090 Its own regulation is disrupted during the onset and progression of cancer and autoimmune disorders such as psoriasis and systemic lupus erythematosus. -other hsa-mir-155 Ankylosing Spondylitis 27412942 Conclusion XFC could effectively improve hypercoagulative state in active AS patients. The potential mechanism may be associated with the inhibition of miR-155 and NF-κB signal pathway. -other hsa-let-7a "Carcinoma, Ovarian" 27419385 Identification of stably expressed reference small non-coding RNAs for microRNA quantification in high-grade serous ovarian carcinoma tissues. -other hsa-mir-103a "Carcinoma, Ovarian" 27419385 Identification of stably expressed reference small non-coding RNAs for microRNA quantification in high-grade serous ovarian carcinoma tissues. -other hsa-mir-16 "Carcinoma, Ovarian" 27419385 Identification of stably expressed reference small non-coding RNAs for microRNA quantification in high-grade serous ovarian carcinoma tissues. -other hsa-mir-191 "Carcinoma, Ovarian" 27419385 Identification of stably expressed reference small non-coding RNAs for microRNA quantification in high-grade serous ovarian carcinoma tissues. -other hsa-mir-423 "Carcinoma, Ovarian" 27419385 Identification of stably expressed reference small non-coding RNAs for microRNA quantification in high-grade serous ovarian carcinoma tissues. -other hsa-mir-92a "Carcinoma, Ovarian" 27419385 Identification of stably expressed reference small non-coding RNAs for microRNA quantification in high-grade serous ovarian carcinoma tissues. -other hsa-mir-221 Breast Neoplasms 27420990 "The expression of miR-221/222 in the serum of the patients with post-menopausal breast cancer was higher than that of T2DM patients (P < 0.05), but lower than that of the T2DM patients who were also positive for post-menopausal breast cancer (P < 0.05);" -other hsa-mir-221 "Diabetes Mellitus, Type 2" 27420990 "The expression of miR-221/222 in the serum of the patients with post-menopausal breast cancer was higher than that of T2DM patients (P < 0.05), but lower than that of the T2DM patients who were also positive for post-menopausal breast cancer (P < 0.05)" -other hsa-mir-222 Breast Neoplasms 27420990 "The expression of miR-221/222 in the serum of the patients with post-menopausal breast cancer was higher than that of T2DM patients (P < 0.05), but lower than that of the T2DM patients who were also positive for post-menopausal breast cancer (P < 0.05)" -other hsa-mir-222 "Diabetes Mellitus, Type 2" 27420990 "The expression of miR-221/222 in the serum of the patients with post-menopausal breast cancer was higher than that of T2DM patients (P < 0.05), but lower than that of the T2DM patients who were also positive for post-menopausal breast cancer (P < 0.05)" -other hsa-mir-130a "Leukemia, Myeloid, Chronic" 27421670 "Here, the L-amino acid oxidase from Calloselasma rhodostoma (CR-LAAO) venom altered the apoptotic machinery regulation by modulating the expression of the miR-145, miR-26a, miR-142-3p, miR-21, miR-130a, and miR-146a, and of the apoptosis-related proteins Bid, Bim, Bcl-2, Ciap-2, c-Flip, and Mcl-1 in Bcr-Abl(+) cells." -other hsa-mir-142 "Leukemia, Myeloid, Chronic" 27421670 "Here, the L-amino acid oxidase from Calloselasma rhodostoma (CR-LAAO) venom altered the apoptotic machinery regulation by modulating the expression of the miR-145, miR-26a, miR-142-3p, miR-21, miR-130a, and miR-146a, and of the apoptosis-related proteins Bid, Bim, Bcl-2, Ciap-2, c-Flip, and Mcl-1 in Bcr-Abl(+) cells." -other hsa-mir-145 "Leukemia, Myeloid, Chronic" 27421670 "Here, the L-amino acid oxidase from Calloselasma rhodostoma (CR-LAAO) venom altered the apoptotic machinery regulation by modulating the expression of the miR-145, miR-26a, miR-142-3p, miR-21, miR-130a, and miR-146a, and of the apoptosis-related proteins Bid, Bim, Bcl-2, Ciap-2, c-Flip, and Mcl-1 in Bcr-Abl(+) cells." -other hsa-mir-146a "Leukemia, Myeloid, Chronic" 27421670 "Here, the L-amino acid oxidase from Calloselasma rhodostoma (CR-LAAO) venom altered the apoptotic machinery regulation by modulating the expression of the miR-145, miR-26a, miR-142-3p, miR-21, miR-130a, and miR-146a, and of the apoptosis-related proteins Bid, Bim, Bcl-2, Ciap-2, c-Flip, and Mcl-1 in Bcr-Abl(+) cells." -other hsa-mir-21 "Leukemia, Myeloid, Chronic" 27421670 "Here, the L-amino acid oxidase from Calloselasma rhodostoma (CR-LAAO) venom altered the apoptotic machinery regulation by modulating the expression of the miR-145, miR-26a, miR-142-3p, miR-21, miR-130a, and miR-146a, and of the apoptosis-related proteins Bid, Bim, Bcl-2, Ciap-2, c-Flip, and Mcl-1 in Bcr-Abl(+) cells." -other hsa-mir-26a "Leukemia, Myeloid, Chronic" 27421670 "Here, the L-amino acid oxidase from Calloselasma rhodostoma (CR-LAAO) venom altered the apoptotic machinery regulation by modulating the expression of the miR-145, miR-26a, miR-142-3p, miR-21, miR-130a, and miR-146a, and of the apoptosis-related proteins Bid, Bim, Bcl-2, Ciap-2, c-Flip, and Mcl-1 in Bcr-Abl(+) cells." -other hsa-mir-21 "Lymphoma, T-Cell, Cutaneous" 27422033 "Our findings not only demonstrate a critical role for IL15-mediated inflammation in cutaneous T-cell lymphomagenesis, but also uncover a new oncogenic regulatory loop in CTCL involving IL15, HDAC1, HDAC6, and miR-21 that shows differential sensitivity to isotype-specific HDAC inhibitors." -other hsa-mir-98 "Squamous Cell Carcinoma, Esophageal" 27422937 "AmiR-98 mimic enforced the expression of miRNA-98 and made ESCC cells sensitive to radiotherapy, while anti-miR-98 reversed this process." -other hsa-mir-27a Osteosarcoma 27429847 "Moreover, our findings suggested that the modulatory effects of PG on EMMPRIN were due, at least in part, to regulation of an ROS-miR-27a/ZBTB10-Sp1 transcription factor pathway." -other hsa-mir-142 Periodontal Diseases 27429973 "In conclusion, five miRNAs have consistently been reported for periodontitis; however, their disease specificity, detectability, and expression in saliva and their importance as noninvasive markers are questionable." -other hsa-mir-146a Periodontal Diseases 27429973 "In conclusion, five miRNAs have consistently been reported for periodontitis; however, their disease specificity, detectability, and expression in saliva and their importance as noninvasive markers are questionable." -other hsa-mir-155 Periodontal Diseases 27429973 "In conclusion, five miRNAs have consistently been reported for periodontitis; however, their disease specificity, detectability, and expression in saliva and their importance as noninvasive markers are questionable." -other hsa-mir-203 Periodontal Diseases 27429973 "In conclusion, five miRNAs have consistently been reported for periodontitis; however, their disease specificity, detectability, and expression in saliva and their importance as noninvasive markers are questionable." -other hsa-mir-223 Periodontal Diseases 27429973 "In conclusion, five miRNAs have consistently been reported for periodontitis; however, their disease specificity, detectability, and expression in saliva and their importance as noninvasive markers are questionable." -other hsa-mir-16 Glioma 27430517 apigenin inhibits glioma cell growth through promoting miR?16 and suppression of BCL2 and NF-¦ÊB/MMP-9 -other hsa-mir-29b Multiple Myeloma 27430753 Paeoniflorin inhibits proliferation and promotes apoptosis of multiple myeloma cells via its effects on microRNAâ€?9b and matrix metalloproteinaseâ€?. -other hsa-mir-146b "Leukemia, Lymphocytic, Chronic, B-Cell" 27431016 "When evaluated in CLL cells from 38 patients pre and post treatment with ibrutinib, a subset of these miRNAs (miR-22, miR-34a, miR-146b and miR-181b) was significantly decreased in response to ibrutinib." -other hsa-mir-181b "Leukemia, Lymphocytic, Chronic, B-Cell" 27431016 "When evaluated in CLL cells from 38 patients pre and post treatment with ibrutinib, a subset of these miRNAs (miR-22, miR-34a, miR-146b and miR-181b) was significantly decreased in response to ibrutinib." -other hsa-mir-22 "Leukemia, Lymphocytic, Chronic, B-Cell" 27431016 "When evaluated in CLL cells from 38 patients pre and post treatment with ibrutinib, a subset of these miRNAs (miR-22, miR-34a, miR-146b and miR-181b) was significantly decreased in response to ibrutinib." -other hsa-mir-34a "Leukemia, Lymphocytic, Chronic, B-Cell" 27431016 "When evaluated in CLL cells from 38 patients pre and post treatment with ibrutinib, a subset of these miRNAs (miR-22, miR-34a, miR-146b and miR-181b) was significantly decreased in response to ibrutinib." -other hsa-mir-200c Kidney Injury 27431456 Chromium upper tertile was also associated with higher urinary miR-200c (500 copies/μl) and miR-423 (189 copies/μL). -other hsa-mir-423 Kidney Injury 27431456 Chromium upper tertile was also associated with higher urinary miR-200c (500 copies/μl) and miR-423 (189 copies/μL). -other hsa-mir-223 Spinal Cord Injuries 27432064 Naringenin inhibits spinal cord injury-induced activation of neutrophils through miR-223. -other hsa-mir-204 Diabetes Mellitus 27438705 "Its pathological functions have been observed in a few diseases including pulmonary arterial hypertension, diabetes, and various types of cancers." -other hsa-mir-204 Endometrial Neoplasms 27438705 "It is believed that miR-204 acts as a tumor-suppressor via promoting apoptosis, conferring the resistance of cancer cells to chemotherapy, and suppressing the self-renewal of cancer stem cells (CSCs) and the epithelial to mesenchymal transition (EMT)." -other hsa-mir-204 Hypertension 27438705 "Its pathological functions have been observed in a few diseases including pulmonary arterial hypertension, diabetes, and various types of cancers." -other hsa-mir-204 Prostate Neoplasms 27438705 "It is believed that miR-204 acts as a tumor-suppressor via promoting apoptosis, conferring the resistance of cancer cells to chemotherapy, and suppressing the self-renewal of cancer stem cells (CSCs) and the epithelial to mesenchymal transition (EMT)." -other hsa-mir-204 Pulmonary Hypertension 27438705 "Its pathological functions have been observed in a few diseases including pulmonary arterial hypertension, diabetes, and various types of cancers." -other hsa-mir-122 Hepatitis C Virus Infection 27440892 the expression of CAMP in nonhepatic 293T cells expressing claudin 1 and microRNA miR-122 confers complete propagation of HCV. -other hsa-mir-519d "Carcinoma, Lung, Non-Small-Cell" 27447710 "The aim of the study was to evaluate the expression levels of selected miRNAs: miR-26a, miR-29b and miR-519d, and their target gene, matrix metalloproteinase-2 (MMP-2) in patients with non-small cell lung cancer (NSCLC)." -other hsa-mir-137 Glioblastoma 27448441 "Furthermore, combining miR-137 and antimiR-10b synergizes with the receptor inhibitory function of aptamer carriers and prevents GSC expansion." -other hsa-mir-122 "Carcinoma, Hepatocellular" 27450327 "In this system, we developed a conditionally replicative adenovirus (CRAd) loaded on human umbilical cord-derived mesenchymal stem cells (HUMSCs), in which the CRAd contained an adenovirus E1A gene dual regulated by α-fetoprotein promoter and microRNA-122 target sequence." -other hsa-mir-7 Systemic Lupus Erythematosus 27450756 The clearest case is one circRNA CDR1as that serves as sponge of miR-7. -other hsa-mir-133a Preterm Labor 27452435 IAI is associated with a transcriptional signature consistent with acute inflammation in the villous trophoblast. -other hsa-mir-18a Preterm Labor 27452440 "MALP-2 did not cause apoptosis but did lead to significant secretion of IL-4, IL-6, and IL-8 (P < 0.05, 0.01, 0.001, respectively) and significant changes in miRNA-320a and miRNA-18a (P < 0.05)." -other hsa-mir-155 Pancreatic Adenocarcinoma 27456015 "whereas miRNA-30c, miRNA-21, and miRNA-155 levels and CK19 mRNA levels in station 8 nodes were variable and did not correlate with RFS or OS." -other hsa-mir-33b Gastric Neoplasms 27456358 Curcumin inhibits cell growth and induces cell apoptosis through upregulation of miR-33b in gastric cancer. -other hsa-mir-627 Colon Neoplasms 27458137 "In addition, overexpression of miR-627 or siRNA knockdown of CYP3A4 enhanced the efficacy of irinotecan in growth inhibition and apoptosis induction." -other hsa-mir-211 Chromosome 15q13.3 Microdeletion Syndrome 27459725 The 15q13.3 microdeletion syndrome is caused by a 1.5-MB hemizygous microdeletion located on 15q13.3 affecting seven genes: FAN1; MTMR10; TRPM1; miR-211; KLF13; OTUD7A; and CHRNA7 -other hsa-mir-326 "Adenocarcinoma, Lung" 27460077 Overexpression of miR-326 reversed cisplatin chemoresistance of LAD cells in vitro and in vivo. -other hsa-mir-200 "Carcinoma, Colon" 27460529 Niclosamide inhibits colon cancer progression through downregulation of the Notch pathway and upregulation of the tumor suppressor miR-200 family. -other hsa-mir-16 Osteosarcoma 27460987 "Moreover, GLIPR1 overexpression upregulated miR-16 in osteosarcoma cells." -other hsa-mir-146a Asthma 27463381 "Chitin induced the expression of miR-155, miR-146a and miR-21, each of which is known to up-regulate the expression of pro-inflammatory cytokines." -other hsa-mir-146a "Carcinoma, Lung" 27463381 "Chitin induced the expression of miR-155, miR-146a and miR-21, each of which is known to up-regulate the expression of pro-inflammatory cytokines." -other hsa-mir-155 Asthma 27463381 "Chitin induced the expression of miR-155, miR-146a and miR-21, each of which is known to up-regulate the expression of pro-inflammatory cytokines." -other hsa-mir-155 "Carcinoma, Lung" 27463381 "Chitin also induced the expression of the key pattern recognition receptors TLR2 and TLR4. Chitin induced the expression of miR-155, miR-146a and miR-21, each of which is known to up-regulate the expression of pro-inflammatory cytokines." -other hsa-mir-21 Asthma 27463381 "Chitin induced the expression of miR-155, miR-146a and miR-21, each of which is known to up-regulate the expression of pro-inflammatory cytokines." -other hsa-mir-21 "Carcinoma, Lung" 27463381 "Chitin induced the expression of miR-155, miR-146a and miR-21, each of which is known to up-regulate the expression of pro-inflammatory cytokines." -other hsa-mir-126 Rheumatoid Arthritis 27465842 CCN1 induced VEGF expression in osteoblasts and increased endothelial progenitor cells (EPCs) angiogenesis by inhibiting miR-126 via the protein kinase C-alpha (PKC-α) signaling pathway. -other hsa-mir-10b Glioblastoma 27467502 Regulation of Cell Proliferation and Migration by miR-203 via GAS41/miR-10b Axis in Human Glioblastoma Cells. -other hsa-mir-9 Breast Neoplasms 27468688 Exosome-mediated delivery of miR-9 induces cancer-associated fibroblast-like properties in human breast fibroblasts. -other hsa-mir-155 "Carcinoma, Breast" 27470349 "Therefore, through the anti-glycolytic effect and breakage of the JAK/STAT3/SOCS1 feedback loop via miR-155-5p, 3B may potentially serve as a potential therapeutic agent against breast cancer." -other hsa-mir-34a Holt-Oram Syndrome 27471727 This approach allowed to discover complex regulatory circuits involving novel miRNAs and protein coding genes not considered before in the HOS such as miR-34a and miR-30 and their targets. -other hsa-mir-195 Intrahepatic Cholangiocarcinoma 27474881 Extracellular vesicles carry microRNA-195 to intrahepatic cholangiocarcinoma and improve survival in a rat model. -other hsa-let-7a Cardiomyopathy 27475403 "Six miRNAs seem to be associated with these 2 pathways, which include hsa-miR-19b-1-5p, hsa-miR-1295a, hsa-let-7a-5p, hsa-miR-99b-3p, hsa-miR-16-1-3p, and hsa-miR-34b-3p" -other hsa-mir-1295a Cardiomyopathy 27475403 "Six miRNAs seem to be associated with these 2 pathways, which include hsa-miR-19b-1-5p, hsa-miR-1295a, hsa-let-7a-5p, hsa-miR-99b-3p, hsa-miR-16-1-3p, and hsa-miR-34b-3p" -other hsa-mir-16-1 Cardiomyopathy 27475403 "Six miRNAs seem to be associated with these 2 pathways, which include hsa-miR-19b-1-5p, hsa-miR-1295a, hsa-let-7a-5p, hsa-miR-99b-3p, hsa-miR-16-1-3p, and hsa-miR-34b-3p" -other hsa-mir-19b-1 Cardiomyopathy 27475403 "Six miRNAs seem to be associated with these 2 pathways, which include hsa-miR-19b-1-5p, hsa-miR-1295a, hsa-let-7a-5p, hsa-miR-99b-3p, hsa-miR-16-1-3p, and hsa-miR-34b-3p" -other hsa-mir-34b Cardiomyopathy 27475403 "Six miRNAs seem to be associated with these 2 pathways, which include hsa-miR-19b-1-5p, hsa-miR-1295a, hsa-let-7a-5p, hsa-miR-99b-3p, hsa-miR-16-1-3p, and hsa-miR-34b-3p" -other hsa-mir-99b Cardiomyopathy 27475403 "Six miRNAs seem to be associated with these 2 pathways, which include hsa-miR-19b-1-5p, hsa-miR-1295a, hsa-let-7a-5p, hsa-miR-99b-3p, hsa-miR-16-1-3p, and hsa-miR-34b-3p" -other hsa-mir-125b Psoriasis 27479112 "Based on our bioinformatical pipeline, ubiquitin-specific peptidase 2 was selected as a likely candidate for a mechanistic explanation for psoriasis association." -other hsa-mir-29a Liver Cirrhosis 27480597 MiR-29a exhibited anti-fibrotic effect without cell toxicity in vivo and directly suppressed the expression of PDGF-related genes as well as COL1A1 and induced apoptosis of LX-2 cells. -other hsa-mir-30d Choriocarcinoma 27481218 "Following transient transfection of mir-30d mimic, the disrupted attachment and outgrowth of JAR spheroids was partially restored in the model." -other hsa-mir-558 "Carcinoma, Lung" 27485693 "By contrast, in the cells exposed to 4, 6 or 8 Gy, the administration of miRâ€?58 mimics or AATK specific siRNA significantly promoted cell survival rate and overexpression of AATK reversed this effect." -other hsa-mir-206 Rhabdomyosarcoma 27488535 Heme Oxygenase-1 Controls an HDAC4-miR-206 Pathway of Oxidative Stress in Rhabdomyosarcoma. -other hsa-mir-17 Allergic Rhinitis 27491928 "The results showed that the levels of miR-19a, but not the rest of the 5 members (miR-17, miR-18a, miR-19b, miR-20a, and miR-92a), were significantly higher in peripheral B cells from AR patients as than in B cells from healthy participants." -other hsa-mir-18a Allergic Rhinitis 27491928 "The results showed that the levels of miR-19a, but not the rest of the 5 members (miR-17, miR-18a, miR-19b, miR-20a, and miR-92a), were significantly higher in peripheral B cells from AR patients as than in B cells from healthy participants." -other hsa-mir-19b Allergic Rhinitis 27491928 "The results showed that the levels of miR-19a, but not the rest of the 5 members (miR-17, miR-18a, miR-19b, miR-20a, and miR-92a), were significantly higher in peripheral B cells from AR patients as than in B cells from healthy participants." -other hsa-mir-20a Allergic Rhinitis 27491928 "The results showed that the levels of miR-19a, but not the rest of the 5 members (miR-17, miR-18a, miR-19b, miR-20a, and miR-92a), were significantly higher in peripheral B cells from AR patients as than in B cells from healthy participants." -other hsa-mir-92a Allergic Rhinitis 27491928 "The results showed that the levels of miR-19a, but not the rest of the 5 members (miR-17, miR-18a, miR-19b, miR-20a, and miR-92a), were significantly higher in peripheral B cells from AR patients as than in B cells from healthy participants." -other hsa-mir-23a "Adenocarcinoma, Lung" 27492069 "In addition, miR-23a was significantly enriched in the exosomes after mesenchymal transition." -other hsa-mir-34c Bone Disease [unspecific] 27492554 "Taken together, our studies suggested that Icariine restored LPS-induced bone loss by downregulating miR-34c level and suppressing JNKs, p38, and NF-kB pathways, which highlighted the potential use of Icariine as a therapeutic agent in the treatment of bacteria-induced bone loss diseases." -other hsa-mir-19b Neuroblastoma 27492819 Suppression of miR-19b may enhance the cytotoxic effects of mTOR inhibitors in neuroblastoma cells -other hsa-let-7 "Leukemia, Myeloid, Chronic" 27494666 "ADAR1 restores expression of let-7 and efficiently kills LSCs, providing an innovative therapeutic target in CML." -other hsa-mir-21 Multiple Myeloma 27494872 miR-21 and miR-221/222 could negatively modulate drug sensitivity of MM cells. -other hsa-let-7f Hepatitis C Virus Infection 27496568 "these functional miRNAs, mainly represented by let-7f, miR-145, miR-199a, and miR-221 released from uMSC-Exo, largely contributed to the suppression of HCV RNA replication." -other hsa-mir-145 Hepatitis C Virus Infection 27496568 "these functional miRNAs, mainly represented by let-7f, miR-145, miR-199a, and miR-221 released from uMSC-Exo, largely contributed to the suppression of HCV RNA replication." -other hsa-mir-199a Hepatitis C Virus Infection 27496568 "these functional miRNAs, mainly represented by let-7f, miR-145, miR-199a, and miR-221 released from uMSC-Exo, largely contributed to the suppression of HCV RNA replication." -other hsa-mir-221 Hepatitis C Virus Infection 27496568 "these functional miRNAs, mainly represented by let-7f, miR-145, miR-199a, and miR-221 released from uMSC-Exo, largely contributed to the suppression of HCV RNA replication." -other hsa-mir-29b "Carcinoma, Gastric" 27497248 "Taken together, our results suggested that RUNX3-mediated up-regulation of miR-29b inhibited the proliferation and migration of gastric cancer cells by targeting KDM2A, representing a novel molecular mechanism for the tumor suppression action of RUNX3." -other hsa-mir-200a Neoplasms [unspecific] 27497669 "In conclusion, LEFTY2 down-regulates MKi67 expression and FAK activity, up-regulates miR-200a and E-cadherin, and is thus a powerful negative regulator of endometrial cell proliferation and migration." -other hsa-mir-410 Neuroblastoma 27498840 "In conclusion, the present study demonstrates that the overexpression of SPARC in combination with radiation reduced tumor angiogenesis by downregulating VEGF-A via miR-410." -other hsa-let-7 Perlman Syndrome 27498873 we found that Dis3l2 specifically recognizes and degrades uridylated pre-let-7 microRNA -other hsa-mir-125b Neoplasms [unspecific] 27500388 "along with modulation of wt-p53 and miR-125b expression, we also show that the exosomes (i.e., wt-p53/exo, miR-125b/exo and combination/exo) have a reprogramed global miRNA profile." -other hsa-mir-21 Astrocytoma 27504157 "Our data showed that in 1321N1 cells, β-adrenergic-Epac pathway stimulation up and down-regulated Cx43 and miR-21 expression respectively." -other hsa-mir-21 Glioma 27504157 "Our data showed that in 1321N1 cells, E2-adrenergic-Epac pathway stimulation up and down-regulated Cx43 and miR-21 expression respectively." -other hsa-mir-4443 "Carcinoma, Breast" 27504971 "We revealed that miR-4443 induced malignancy of breast cancer mainly in chemo-resistance aspect for the very first time, providing a novel biomarker in breast cancer diagnosis and therapy." -other hsa-mir-17 Kaposi Sarcoma 27512057 "Here, we provide the first experimental evidence of JMRV miRNAs in vitro and demonstrate that one of these viral miRNAs can mimic the activity of the cellular miR-17/20/106 family." -other hsa-mir-17 Multiple Sclerosis 27512057 "Here, we provide the first experimental evidence of JMRV miRNAs in vitro and demonstrate that one of these viral miRNAs can mimic the activity of the cellular miR-17/20/106 family." -other hsa-mir-17 Polycystic Kidney Disease 27512774 One of the mechanisms through which the miR-17~92 cluster aggravates to cyst growth is by promoting proliferation of the cyst epithelial cells. -other hsa-mir-155 Myelodysplastic Syndromes 27513856 "In the current study, we identified overexpression of c-Fos-targeting miR-34a and miR-155 as the cause of impairment." -other hsa-mir-34a Myelodysplastic Syndromes 27513856 "In the current study, we identified overexpression of c-Fos-targeting miR-34a and miR-155 as the cause of impairment." -other hsa-mir-29a "Carcinoma, Breast" 27523474 miR-29a may be a potential target for the patients who acquired ADR-resistance during the treatment of breast cancer. -other hsa-mir-135a "Carcinoma, Prostate" 27524492 Our data support a model in which hsa-miR-135-1 acts as a potential tumor suppressor in metastatic prostate cancer. -other hsa-mir-210 Preeclampsia 27529341 "Some of the most frequently differentially expressed miRs in PE include miR-210, miR-223 and miR-126/126* which associate strongly with the etiological domains of hypoxia, immunology and angiogenesis." -other hsa-mir-126 "Leukemia, Lymphoblastic" 27535859 Bioinformatics analysis of microRNA comprehensive regulatory network in B- cell acute lymphoblastic leukemia. -other hsa-mir-138 "Carcinoma, Esophageal" 27536892 ¦Á-Solanine Modulates the Radiosensitivity of Esophageal Cancer Cells by Inducing MicroRNA 138 Expression. -other hsa-mir-214 "Carcinoma, Colon" 27537384 "MicroRNA-214 suppresses growth, migration and invasion through a novel target, high mobility group AT-hook 1, in human cervical and colorectal cancer cells." -other hsa-mir-124 Stroke 27539642 Dynamic Modulation of Microglia/Macrophage Polarization by miR-124 after Focal Cerebral Ischemia. -other hsa-mir-503 "Carcinoma, Breast" 27539783 An integrative transcriptomics approach identifies miR-503 as a candidate master regulator of the estrogen response in MCF-7 breast cancer cells. -other hsa-mir-1 "Carcinoma, Lung" 27541266 Reprogramming of Normal Fibroblasts into Cancer-Associated Fibroblasts by miRNAs-Mediated CCL2/VEGFA Signaling. -other hsa-mir-206 "Carcinoma, Lung" 27541266 Reprogramming of Normal Fibroblasts into Cancer-Associated Fibroblasts by miRNAs-Mediated CCL2/VEGFA Signaling. -other hsa-mir-31 "Carcinoma, Lung" 27541266 Reprogramming of Normal Fibroblasts into Cancer-Associated Fibroblasts by miRNAs-Mediated CCL2/VEGFA Signaling. -other hsa-mir-21 Vascular Hypertrophy 27542393 MicroRNA-21 Lowers Blood Pressure in Spontaneous Hypertensive Rats by Upregulating Mitochondrial Translation. -other hsa-mir-208b Atrial Fibrillation 27545043 miR-208b upregulation interferes with calcium handling in HL-1 atrial myocytes: Implications in human chronic atrial fibrillation. -other hsa-mir-21 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 27545281 MicroRNA-21 in laryngeal squamous cell carcinoma: Diagnostic and prognostic features. -other hsa-mir-211 Melanoma 27548915 Melanoma miRNA trafficking controls tumour primary niche formation. -other hsa-mir-429 "Carcinoma, Renal Cell, Clear-Cell" 27549611 Epithelial-mesenchymal transition-associated microRNA/mRNA signature is linked to metastasis and prognosis in clear-cell renal cell carcinoma. -other hsa-mir-146b "Leukemia, Lymphoblastic, Acute, T-Cell" 27550837 MiR-146b negatively regulates migration and delays progression of T-cell acute lymphoblastic leukemia. -other hsa-mir-210 "Carcinoma, Adrenocortical" 27550961 Preclinical progress and first translational steps for a liposomal chemotherapy protocol against adrenocortical carcinoma. -other hsa-mir-145 Osteogenesis Imperfecta 27551756 Ossotide promotes cell differentiation of human osteoblasts from osteogenesis imperfecta patients by up-regulating miR-145. -other hsa-mir-383 "Carcinoma, Lung, Non-Small-Cell" 27551765 MicroRNA-383 is a tumor suppressor and potential prognostic biomarker in human non-small cell lung caner. -other hsa-mir-483 "Carcinoma, Ovarian" 27554045 PKC-alpha modulation by miR-483-3p in platinum-resistant ovarian carcinoma cells. -other hsa-mir-29b "Carcinoma, Lung, Non-Small-Cell" 27555773 Aptamer-hybrid nanoparticle bioconjugate efficiently delivers miRNA-29b to non-small-cell lung cancer cells and inhibits growth by downregulating essential oncoproteins. -other hsa-mir-145 "Squamous Cell Carcinoma, Oral" 27557511 "Acquisition cancer stemness, mesenchymal transdifferentiation, and chemoresistance properties by chronic exposure of oral epithelial cells to arecoline." -other hsa-mir-206 Glioblastoma 27558109 MicroRNA-206 Inhibited the Progression of Glioblastoma Through BCL-2. -other hsa-let-7a "Diabetes Mellitus, Gestational" 27562513 Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA. -other hsa-let-7g "Diabetes Mellitus, Gestational" 27562513 Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA. -other hsa-mir-126 "Diabetes Mellitus, Gestational" 27562513 Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA. -other hsa-mir-130b "Diabetes Mellitus, Gestational" 27562513 Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA. -other hsa-mir-148a "Diabetes Mellitus, Gestational" 27562513 Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA. -other hsa-mir-30c "Diabetes Mellitus, Gestational" 27562513 Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA. -other hsa-mir-452 "Diabetes Mellitus, Gestational" 27562513 Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA. -other hsa-mir-139 "Carcinoma, Prostate" 27562849 MiR-139-5p is Increased in the Peripheral Blood of Patients with Prostate Cancer. -other hsa-mir-630 "Squamous Cell Carcinoma, Esophageal" 27563011 MiR-630 inhibits invasion and metastasis in esophageal squamous cell carcinoma. -other hsa-mir-21 Bronchiolitis Obliterans Syndrome 27564214 Identification of miRNAs Potentially Involved in Bronchiolitis Obliterans Syndrome: A Computational Study. -other hsa-mir-34a Bronchiolitis Obliterans Syndrome 27564214 Identification of miRNAs Potentially Involved in Bronchiolitis Obliterans Syndrome: A Computational Study. -other hsa-mir-222 "Carcinoma, Lung" 27566197 Panax notoginseng saponins attenuate lung cancer growth in part through modulating the level of Met/miR-222 axis. -other hsa-mir-383 "Carcinoma, Ovarian" 27567588 Inhibition of microRNA-383 has tumor suppressive effect in human epithelial ovarian cancer through the action on caspase-2 gene. -other hsa-mir-146a Psoriasis 27568078 MicroRNA-146a suppresses IL-17-mediated skin inflammation and is genetically associated with psoriasis. -other hsa-mir-222 "Carcinoma, Breast" 27569215 Mesenchymal Stem Cell-Derived Exosomes Stimulate Cycling Quiescence and Early Breast Cancer Dormancy in Bone Marrow. -other hsa-mir-223 "Carcinoma, Breast" 27569215 Mesenchymal Stem Cell-Derived Exosomes Stimulate Cycling Quiescence and Early Breast Cancer Dormancy in Bone Marrow. -other hsa-mir-29a "Adenocarcinoma, Lung" 27569280 Respiratory syncytial virus non-structural protein 1 facilitates virus replication through miR-29a-mediated inhibition of interferon-¦Á receptor. -other hsa-mir-21 Autism Spectrum Disorder 27571009 "Genome-wide, integrative analysis implicates microRNA dysregulation in autism spectrum disorder." -other hsa-mir-211 Melanoma 27571736 Pigmented melanosomes are now shown to have a relevant role in establishing a tumour niche in primary melanoma by reprogramming dermal fibroblasts into cancer-associated fibroblasts through the transfer of miR-211 -other hsa-mir-107 "Carcinoma, Hepatocellular" 27571925 Heme oxygenase-1 retards hepatocellular carcinoma progression through the microRNA pathway. -other hsa-mir-30d "Carcinoma, Hepatocellular" 27571925 Heme oxygenase-1 retards hepatocellular carcinoma progression through the microRNA pathway. -other hsa-mir-137 "Squamous Cell Carcinoma, Tongue" 27571935 "MicroRNA-137 suppresses tongue squamous carcinoma cell proliferation, migration and invasion." -other hsa-mir-204 Colorectal Carcinoma 27571956 Weighted gene co-expression network analysis of colorectal cancer liver metastasis genome sequencing data and screening of anti-metastasis drugs. -other hsa-mir-455 Colorectal Carcinoma 27571956 Weighted gene co-expression network analysis of colorectal cancer liver metastasis genome sequencing data and screening of anti-metastasis drugs. -other hsa-mir-195 Neoplasms [unspecific] 27572273 MicroRNA-195 targets VEGFR2 and has a tumor suppressive role in ACHN cells via PI3K/Akt and Raf/MEK/ERK signaling pathways. -other hsa-mir-144 "Carcinoma, Esophageal" 27572636 Possible tumor suppressive role of the miR-144/451 cluster in esophageal carcinoma as determined by principal component regression analysis. -other hsa-mir-451 "Carcinoma, Esophageal" 27572636 Possible tumor suppressive role of the miR-144/451 cluster in esophageal carcinoma as determined by principal component regression analysis. -other hsa-mir-194 Melanoma 27573550 miR-194 is a negative regulator of GEF-H1 pathway in melanoma. -other hsa-mir-1246 "Carcinoma, Biliary Tract" 27573701 miR?1246 and miR?4644 in salivary exosome as potential biomarkers for pancreatobiliary tract cancer. -other hsa-mir-4644 "Carcinoma, Biliary Tract" 27573701 miR?1246 and miR?4644 in salivary exosome as potential biomarkers for pancreatobiliary tract cancer. -other hsa-mir-892b "Carcinoma, Bladder" 27573859 "MicroRNA-892b influences proliferation, migration and invasion of bladder cancer cells by mediating the p19ARF/cyclin D1/CDK6 and Sp-1/MMP-9 pathways." -other hsa-mir-195 Glioma 27574009 TGF-¦Â1 regulating miR-205/miR-195 expression affects the TGF-¦Â signal pathway by respectively targeting SMAD2/SMAD7. -other hsa-mir-205 Glioma 27574009 TGF-¦Â1 regulating miR-205/miR-195 expression affects the TGF-¦Â signal pathway by respectively targeting SMAD2/SMAD7. -other hsa-let-7 "Carcinoma, Breast" 27574028 Let?7 miRNAs sensitize breast cancer stem cells to radiation?induced repression through inhibition of the cyclin?D1/Akt1/Wnt1 signaling pathway. -other hsa-mir-494 "Adenocarcinoma, Lung" 27575252 Discriminating between Terminal- and Non-Terminal Respiratory Unit-Type Lung Adenocarcinoma Based on MicroRNA Profiles. -other hsa-mir-551b "Adenocarcinoma, Lung" 27575252 Discriminating between Terminal- and Non-Terminal Respiratory Unit-Type Lung Adenocarcinoma Based on MicroRNA Profiles. -other hsa-mir-100 "Carcinoma, Hepatocellular" 27577856 MicroRNAs miR-125b and miR-100 suppress metastasis of hepatocellular carcinoma by disrupting the formation of vessels that encapsulate tumour clusters. -other hsa-mir-125b "Carcinoma, Hepatocellular" 27577856 MicroRNAs miR-125b and miR-100 suppress metastasis of hepatocellular carcinoma by disrupting the formation of vessels that encapsulate tumour clusters. -other hsa-mir-17 Neoplasms [unspecific] 27577994 "miR-17-5p is at the crossroads of aging, longevity and cancer and might represent a promising biomarker or even therapeutic tool and target in this context" -other hsa-mir-122 Hepatitis C Virus Infection 27578438 Unraveling the Mysterious Interactions Between Hepatitis C Virus RNA and Liver-Specific MicroRNA-122. -other hsa-mir-21 "Carcinoma, Breast" 27579604 Distinct Small RNA Signatures in Extracellular Vesicles Derived from Breast Cancer Cell Lines. -other hsa-mir-17 Psoriasis 27579777 miRNA miR-17-92 cluster is differentially regulated in the imiqumod-treated skin but is not required for imiqumod-induced psoriasis-like dermatitis in mice. -other hsa-mir-18 Psoriasis 27579777 miRNA miR-17-92 cluster is differentially regulated in the imiqumod-treated skin but is not required for imiqumod-induced psoriasis-like dermatitis in mice. -other hsa-mir-19a Psoriasis 27579777 miRNA miR-17-92 cluster is differentially regulated in the imiqumod-treated skin but is not required for imiqumod-induced psoriasis-like dermatitis in mice. -other hsa-mir-19b-1 Psoriasis 27579777 miRNA miR-17-92 cluster is differentially regulated in the imiqumod-treated skin but is not required for imiqumod-induced psoriasis-like dermatitis in mice. -other hsa-mir-20a Psoriasis 27579777 miRNA miR-17-92 cluster is differentially regulated in the imiqumod-treated skin but is not required for imiqumod-induced psoriasis-like dermatitis in mice. -other hsa-mir-92-1 Psoriasis 27579777 miRNA miR-17-92 cluster is differentially regulated in the imiqumod-treated skin but is not required for imiqumod-induced psoriasis-like dermatitis in mice. -other hsa-mir-200 "Carcinoma, Renal Cell" 27580029 Loss of fumarate hydratase is associated with suppression of miR-200 and the EMT signature in renal cancer and is associated with poor clinical outcome -other hsa-mir-146a Colorectal Carcinoma 27580100 Numb is involved in the non-random segregation of subcellular vesicles in colorectal cancer stem cells. -other hsa-mir-30a Multiple Sclerosis 27581464 Disulfiram and Diphenhydramine Hydrochloride Upregulate miR-30a to Suppress IL-17-Associated Autoimmune Inflammation. -other hsa-mir-126 Neoplasms [unspecific] 27583885 Potential role of microRNA-126 in the diagnosis of cancers: A systematic review and meta-analysis. -other hsa-mir-21 Psoriasis 27586798 the activation of S100A8/A9-dependent C3 complement as well as a miR-21-dependent TIMP-3/TACE pathway leading to TNF-¦Á shedding -other hsa-mir-155 Hypoxia 27587248 Effect of miR- 155 on immune- factors and its mechanism in mesenchymal stem cells under hypoxic environment. -other hsa-mir-141 "Carcinoma, Prostate" 27589398 Sensitive detection of microRNA in complex biological samples by using two stages DSN-assisted target recycling signal amplification method. -other hsa-mir-203 "Carcinoma, Nasopharyngeal" 27589832 A directly negative interaction of miR-203 and ZEB2 modulates tumor stemness and chemotherapy resistance in nasopharyngeal carcinoma. -other hsa-mir-148a Hepatitis C Virus Infection 27591428 "miR-148a and miR-30a limit HCV-dependent suppression of the lipid droplet protein, ADRP, in HCV infected cell models." -other hsa-mir-30a Chronic Hepatitis C 27591428 "miR-148a and miR-30a limit HCV-dependent suppression of the lipid droplet protein, ADRP, in HCV infected cell models." -other hsa-mir-122 "Diabetes Mellitus, Type 2" 27592052 HNF-4¦Á regulated miR-122 contributes to development of gluconeogenesis and lipid metabolism disorders in Type 2 diabetic mice and in palmitate-treated HepG2 cells. -other hsa-mir-183 Lung Neoplasms 27593936 TFAP2C promotes lung tumorigenesis and aggressiveness through miR-183- and miR-33a-mediated cell cycle regulation. -other hsa-mir-33a Lung Neoplasms 27593936 TFAP2C promotes lung tumorigenesis and aggressiveness through miR-183- and miR-33a-mediated cell cycle regulation. -other hsa-mir-582 "Carcinoma, Colon" 27595705 miR-582-5P induces colorectal cancer cell proliferation by targeting adenomatous polyposis coli. -other hsa-mir-146a Sepsis 27596437 "systemic inflammation induced an increase in EVs and associated pro-inflammatory miRNAs, including miR-146a and miR-155, in the CSF Interestingly, this was associated with an increase in amount of multivesicular bodies (MVBs) and exosomes per MVB in the CPE cells" -other hsa-mir-155 Sepsis 27596437 "systemic inflammation induced an increase in EVs and associated pro-inflammatory miRNAs, including miR-146a and miR-155, in the CSF Interestingly, this was associated with an increase in amount of multivesicular bodies (MVBs) and exosomes per MVB in the CPE cells" -other hsa-mir-4687 "Diabetes Mellitus, Type 2" 27597954 Role of miRNAs in Epicardial Adipose Tissue in CAD Patients with T2DM. -other hsa-mir-21 Retinoblastoma 27600360 MiR-21 inhibitor suppressed the progression of retinoblastoma via the modulation of PTEN/PI3K/AKT pathway. -other hsa-mir-17 Medulloblastoma 27600805 Dicer1 ablation impairs Shh-induced GNP proliferation by disrupting the expression of distinct cell cycle regulator genes that are targets of miR-17/92 cluster members -other hsa-mir-18 Medulloblastoma 27600805 Dicer1 ablation impairs Shh-induced GNP proliferation by disrupting the expression of distinct cell cycle regulator genes that are targets of miR-17/92 cluster members -other hsa-mir-19a Medulloblastoma 27600805 Dicer1 ablation impairs Shh-induced GNP proliferation by disrupting the expression of distinct cell cycle regulator genes that are targets of miR-17/92 cluster members -other hsa-mir-19b-1 Medulloblastoma 27600805 Dicer1 ablation impairs Shh-induced GNP proliferation by disrupting the expression of distinct cell cycle regulator genes that are targets of miR-17/92 cluster members -other hsa-mir-20a Medulloblastoma 27600805 Dicer1 ablation impairs Shh-induced GNP proliferation by disrupting the expression of distinct cell cycle regulator genes that are targets of miR-17/92 cluster members -other hsa-mir-92-1 Medulloblastoma 27600805 Dicer1 ablation impairs Shh-induced GNP proliferation by disrupting the expression of distinct cell cycle regulator genes that are targets of miR-17/92 cluster members -other hsa-mir-200c Ovarian Neoplasms 27601996 miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition. -other hsa-mir-143 "Carcinoma, Lung, Non-Small-Cell" 27602093 miR-143 suppresses the proliferation of NSCLC cells by inhibiting the epidermal growth factor receptor. -other hsa-mir-146b "Carcinoma, Thyroid, Anaplastic" 27602131 p21 participates in the regulation of anaplastic thyroid cancer cell proliferation by miR-146b. -other hsa-mir-27a Lung Neoplasms 27602162 Genistein inhibits A549 human lung cancer cell proliferation via miR-27a and MET signaling. -other hsa-mir-155 Neoplasms [unspecific] 27602769 MiR-155 promotes epithelial-mesenchymal transition in hepatocellular carcinoma cells through the activation of PI3K/SGK3/¦Â-catenin signaling pathways. -other hsa-mir-21 Chronic Kidney Disease 27610006 TGF-¦Â1/Smads and miR-21 in Renal Fibrosis and Inflammation. -other hsa-mir-10b Lymphoma 27611973 Profile of Exosomal and Intracellular microRNA in Gamma-Herpesvirus-Infected Lymphoma Cell Lines. -other hsa-mir-143 Lymphoma 27611973 Profile of Exosomal and Intracellular microRNA in Gamma-Herpesvirus-Infected Lymphoma Cell Lines. -other hsa-mir-27a Pulmonary Hypertension 27612006 Peroxisome Proliferator-Activated Receptor ¦Ã Regulates the V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1/microRNA-27a Axis to Reduce Endothelin-1 and Endothelial Dysfunction in the Sickle Cell Mouse Lung. -other hsa-mir-125b "Leukemia, Promyelocytic, Acute" 27613090 Identification of miR-125b targets involved in acute promyelocytic leukemia cell proliferation. -other hsa-mir-29b Schizophrenia 27613806 Epistatic and Independent Effects on Schizophrenia-Related Phenotypes Following Co-disruption of the Risk Factors Neuregulin-1 ¡Á DISC1. -other hsa-mir-122 Chronic Hepatitis C 27614072 TALEN/CRISPR-mediated engineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus. -other hsa-mir-7 "Carcinoma, Hepatocellular" 27614453 The circular RNA ciRS-7 (Cdr1as) acts as a risk factor of hepatic microvascular invasion in hepatocellular carcinoma. -other hsa-mir-616 Coronary Artery Disease 27615006 Relationship of microRNA 616 gene polymorphism with prognosis of patients with premature coronary artery disease. -other hsa-mir-141 Melanoma 27616325 Trans-nonachlor decreases miR-141-3p levels in human melanocytes in vitro promoting melanoma cell characteristics and shows a multigenerational impact on miR-8 levels in Drosophila. -other hsa-mir-429 "Carcinoma, Renal Cell" 27619681 MiR-429 is linked to metastasis and poor prognosis in renal cell carcinoma by affecting epithelial-mesenchymal transition. -other hsa-mir-92a Melanoma 27620505 miR-92a-3p and MYCBP2 are involved in MS-275-induced and c-myc-mediated TRAIL-sensitivity in melanoma cells. -other hsa-mir-196a "Carcinoma, Esophageal" 27621035 Inhibition of miR-196a affects esophageal cancer cell growth in vitro. -other hsa-mir-100 Vascular Injuries 27622243 Dicer generates a regulatory microRNA network in smooth muscle cells that limits neointima formation during vascular repair. -other hsa-mir-147 Vascular Injuries 27622243 Dicer generates a regulatory microRNA network in smooth muscle cells that limits neointima formation during vascular repair. -other hsa-mir-21 Vascular Injuries 27622243 Dicer generates a regulatory microRNA network in smooth muscle cells that limits neointima formation during vascular repair. -other hsa-mir-222 Vascular Injuries 27622243 Dicer generates a regulatory microRNA network in smooth muscle cells that limits neointima formation during vascular repair. -other hsa-mir-27a Vascular Injuries 27622243 Dicer generates a regulatory microRNA network in smooth muscle cells that limits neointima formation during vascular repair. -other hsa-mir-10b Cardiovascular Diseases [unspecific] 27624142 Potential role of microRNA-10b down-regulation in cardiomyocyte apoptosis in aortic stenosis patients. -other hsa-mir-4787 "Carcinoma, Pancreatic" 27624777 Inhibition of S-Adenosylmethionine-Dependent Methyltransferase Attenuates TGF¦Â1-Induced EMT and Metastasis in Pancreatic Cancer: Putative Roles of miR-663a and miR-4787-5p. -other hsa-mir-663a "Carcinoma, Pancreatic" 27624777 Inhibition of S-Adenosylmethionine-Dependent Methyltransferase Attenuates TGF¦Â1-Induced EMT and Metastasis in Pancreatic Cancer: Putative Roles of miR-663a and miR-4787-5p. -other hsa-mir-1284 "Carcinoma, Gastric" 27627897 MicroRNA-1284 inhibits proliferation and induces apoptosis in SGC-7901 human gastric cancer cells. -other hsa-mir-424 "Squamous Cell Carcinoma, Esophageal" 27628042 MiR-424-5p participates in esophageal squamous cell carcinoma invasion and metastasis via SMAD7 pathway mediated EMT. -other hsa-mir-490 "Squamous Cell Carcinoma, Skin or Unspecific" 27629145 Poly r(C) binding protein is post-transcriptionally repressed by MiR-490-3p to potentiate squamous cell carcinoma. -other hsa-mir-143 Colorectal Carcinoma 27629291 "we showed the importance of interactions between TP53, miR-143, KRAS, BCL2, and PLK1 with respect to colorectal cancer using bioinformatics approach" -other hsa-mir-31 "Carcinoma, Colon" 27630355 Efficacy and Toxicity of Panitumumab After Progression on Cetuximab and Predictive Value of MiR-31-5p in Metastatic Wild-type KRAS Colorectal Cancer Patients. -other hsa-mir-196a Huntington Disease 27631085 miR-196a Ameliorates Cytotoxicity and Cellular Phenotype in Transgenic Huntington's Disease Monkey Neural Cells. -other hsa-mir-378 Myelodysplastic Syndromes 27633496 miR-378 inhibits cell growth and enhances apoptosis in human myelodysplastic syndromes. -other hsa-mir-181a Glioblastoma 27633853 MicroRNA-181a promotes proliferation and inhibits apoptosis by suppressing CFIm25 in osteosarcoma. -other hsa-mir-34a Lung Fibrosis 27635790 miR-34a Inhibits Lung Fibrosis by Inducing Lung Fibroblast Senescence. -other hsa-mir-223 Ischemia-Reperfusion Injury 27635859 Neuroprotective effect of ischemic preconditioning via modulating the expression of cerebral miRNAs against transient cerebral ischemia in diabetic rats. -other hsa-mir-21 "Scleroderma, Systemic" 27637490 Inhibition of MicroRNA-21 induces apoptosis in dermal fibroblasts of patients with systemic sclerosis. -other hsa-mir-302f Congenital Heart Diseases 27637763 Copy-number variant analysis of classic heterotaxy highlights the importance of body patterning pathways. -other hsa-mir-122 Hepatitis C Virus Infection 27641985 "The history of hepatitis C virus (HCV): Basic research reveals unique features in phylogeny, evolution and the viral life cycle with new perspectives for epidemic control." -other hsa-mir-214 "Carcinoma, Lung" 27642589 cir-ITCH acted as sponge of oncogenic miR-7 and miR-214 to enhance ITCH expression and thus suppressed the activation of Wnt/¦Â-catenin signaling -other hsa-mir-7 "Carcinoma, Lung" 27642589 cir-ITCH acted as sponge of oncogenic miR-7 and miR-214 to enhance ITCH expression and thus suppressed the activation of Wnt/¦Â-catenin signaling -other hsa-mir-26a "Carcinoma, Lung, Small-Cell" 27644194 KH-type splicing regulatory protein (KHSRP) contributes to tumorigenesis by promoting miR-26a maturation in small cell lung cancer. -other hsa-mir-221 Atherosclerosis 27644883 Human aortic smooth muscle cell-derived exosomal miR-221/222 inhibits autophagy via a PTEN/Akt signaling pathway in human umbilical vein endothelial cells. -other hsa-mir-222 Atherosclerosis 27644883 Human aortic smooth muscle cell-derived exosomal miR-221/222 inhibits autophagy via a PTEN/Akt signaling pathway in human umbilical vein endothelial cells. -other hsa-mir-124a Neuropathic Pain 27646435 miR-124a and miR-155 enhance differentiation of regulatory T cells in patients with neuropathic pain. -other hsa-mir-155 Neuropathic Pain 27646435 miR-124a and miR-155 enhance differentiation of regulatory T cells in patients with neuropathic pain. -other hsa-mir-106b Multiple Myeloma 27647143 Integrative analysis of signaling pathways and diseases associated with the miR-106b/25 cluster and their function study in?berb?erine-induced multiple myeloma cells. -other hsa-mir-25 Multiple Myeloma 27647143 Integrative analysis of signaling pathways and diseases associated with the miR-106b/25 cluster and their function study in?berb?erine-induced multiple myeloma cells. -other hsa-let-7 Wilms Tumor 27647875 uridylated pre-let-7 miRNAs and mRNAs are targeted by the 3' to 5' exoribonuclease DIS3L2 -other hsa-mir-323b "Leukemia, Lymphoblastic, Acute, B-Cell" 27649261 MiR-pharmacogenetics of methotrexate in childhood B-cell acute lymphoblastic leukemia. -other hsa-mir-137 Glioblastoma 27649660 Circulating microRNA-137 is a potential biomarker for human glioblastoma. -other hsa-mir-137 Schizophrenia 27650867 MicroRNA-137 Inhibits EFNB2 Expression Affected by a Genetic Variant and Is Expressed Aberrantly in Peripheral Blood of Schizophrenia Patients. -other hsa-mir-205 Keloid 27651436 Upregulation of microRNA-205 suppresses vascular endothelial growth factor expression-mediated PI3K/Akt signaling transduction in human keloid fibroblasts. -other hsa-mir-125a "Carcinoma, Breast" 27651454 Structural dynamics control the MicroRNA maturation pathway. -other hsa-mir-628 Cardiac Allograft Vasculopathy 27653298 MicroRNA 628-5p as a Novel Biomarker for Cardiac Allograft Vasculopathy. -other hsa-mir-4697 Parkinson Disease 27653855 "SIPA1L2, MIR4697, GCH1 and VPS13C loci and risk of Parkinson's diseases in Iranian population: A case-control study." -other hsa-mir-203 "Carcinoma, Ovarian" 27655286 MiR-203 promotes the growth and migration of ovarian cancer cells by enhancing glycolytic pathway. -other hsa-mir-205 Endometrial Neoplasms 27655663 Locked nucleic acid-inhibitor of miR-205 decreases endometrial cancer cells proliferation in vitro and in vivo. -other hsa-let-7 Neoplasms [unspecific] 27659051 "Several proteins known to bind immature forms of these let-7 miRNAs were identified, but with an improved coverage compared to previous studies" -other hsa-let-7a Neoplasms [unspecific] 27659051 "Several proteins known to bind immature forms of these let-7 miRNAs were identified, but with an improved coverage compared to previous studies" -other hsa-let-7g Neoplasms [unspecific] 27659051 "Several proteins known to bind immature forms of these let-7 miRNAs were identified, but with an improved coverage compared to previous studies" -other hsa-mir-22 "Carcinoma, Gastric" 27662840 NTRK2 is an oncogene and associated with microRNA-22 regulation in human gastric cancer cell lines. -other hsa-mir-27b Hepatitis C Virus Infection 27665576 Lipoprotein lipase liberates free fatty acids to inhibit HCV infection and prevent hepatic lipid accumulation. -other hsa-mir-374 "Carcinoma, Pancreatic" 27665739 "MicroRNA miR-374, a potential radiosensitizer for carbon ion beam radiotherapy." -other hsa-let-7g Osteoporosis 27665867 An insertion/deletion polymorphism within the 3'?untranslated region of COL1A2 confers susceptibility to osteoporosis. -other hsa-mir-200 "Carcinoma, Colon" 27666412 Colorectal cancer cell-derived microRNA200 modulates the resistance of adjacent blood endothelial barriers in?vitro. -other hsa-mir-424 "Carcinoma, Lung, Non-Small-Cell" 27666545 Effects of miR-424 on Proliferation and Migration Abilities in Non-small Cell Lung Cancer A549 Cells and Its Molecular Mechanism. -other hsa-mir-21 "Cardiomyopathy, Ischemic" 27666568 "Trimetazidine protects against cardiac ischemia/reperfusion injury via effects on cardiac miRNA?21 expression, Akt and the Bcl?2/Bax pathway." -other hsa-mir-743a Wilms Tumor 27667021 Proliferation of metanephric mesenchymal cells is inhibited by miR-743a-mediated WT1 suppression in vitro. -other hsa-mir-139 Primary Biliary Cirrhosis 27668889 "MiR-139-5p is associated with inflammatory regulation through c-FOS suppression, and contributes to the progression of primary biliary cholangitis." -other hsa-mir-122 "Fatty Liver, Non-Alcoholic" 27669236 miR33a/miR33b* and miR122 as Possible Contributors to Hepatic Lipid Metabolism in Obese Women with Nonalcoholic Fatty Liver Disease. -other hsa-mir-33a "Fatty Liver, Non-Alcoholic" 27669236 miR33a/miR33b* and miR122 as Possible Contributors to Hepatic Lipid Metabolism in Obese Women with Nonalcoholic Fatty Liver Disease. -other hsa-mir-33b "Fatty Liver, Non-Alcoholic" 27669236 miR33a/miR33b* and miR122 as Possible Contributors to Hepatic Lipid Metabolism in Obese Women with Nonalcoholic Fatty Liver Disease. -other hsa-mir-146a Muscular Dystrophy 27671199 Chronic alcohol exposure induces muscle atrophy (myopathy) in zebrafish and alters the expression of microRNAs targeting the Notch pathway in skeletal muscle. -other hsa-mir-132 "Carcinoma, Ovarian" 27673409 "MicroRNA and long non-coding RNA have potential clinical utility in the diagnosis of ovarian cancer and predicting prognosis, metastasis, recurrence, and response to therapy" -other hsa-mir-26a "Carcinoma, Ovarian" 27673409 "MicroRNA and long non-coding RNA have potential clinical utility in the diagnosis of ovarian cancer and predicting prognosis, metastasis, recurrence, and response to therapy" -other hsa-mir-126 Hyperglycemia 27673690 Hyperglycemia and Advanced Glycation End Products Regulate miR-126 Expression in Endothelial Progenitor Cells. -other hsa-mir-223 Liver Injury 27679493 MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the IL-6-p47phox-oxidative stress pathway in neutrophils. -other hsa-mir-210 Preeclampsia 27683514 Predictive value of miR-210 as a novel biomarker for pre-eclampsia: a systematic review protocol. -other hsa-mir-155 Hypertension 27683672 Vascular mineralocorticoid receptor regulates microRNA-155 to promote vasoconstriction and rising blood pressure with aging. -other hsa-mir-221 "Carcinoma, Breast" 27686606 A small RNA (miR-221) target was determined via the impedimetric measurement of the hybridization event in a label-free and PCR-free approach -other hsa-mir-22 Heart Failure 27687198 Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction. -other hsa-mir-10a Autoimmune Diseases [unspecific] 27687891 "MicroRNAs such as miR-155, miR-126, and miR-10a also exert an important influence on the differentiation, development, and immunological functions of Tregs" -other hsa-mir-126 Autoimmune Diseases [unspecific] 27687891 "MicroRNAs such as miR-155, miR-126, and miR-10a also exert an important influence on the differentiation, development, and immunological functions of Tregs" -other hsa-mir-155 Autoimmune Diseases [unspecific] 27687891 "MicroRNAs such as miR-155, miR-126, and miR-10a also exert an important influence on the differentiation, development, and immunological functions of Tregs" -other hsa-mir-367 "Carcinoma, Hepatocellular" 27688096 The miR-367-3p Increases Sorafenib Chemotherapy Efficacy to Suppress Hepatocellular Carcinoma Metastasis through Altering the Androgen Receptor Signals. -other hsa-mir-21 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 27688683 "Metformin significantly inhibited FaDu cell proliferation , possibly via downregulation of miR-21-5p and upregulation of PDCD4" -other hsa-mir-146a Cystic Fibrosis 27689251 "miR-146a, miR-155, miR-370, and miR-708 Are CFTR-Dependent, Predicted FOXO1 Regulators and Change at Onset of CFRDs." -other hsa-mir-155 Cystic Fibrosis 27689251 "miR-146a, miR-155, miR-370, and miR-708 Are CFTR-Dependent, Predicted FOXO1 Regulators and Change at Onset of CFRDs." -other hsa-mir-370 Cystic Fibrosis 27689251 "miR-146a, miR-155, miR-370, and miR-708 Are CFTR-Dependent, Predicted FOXO1 Regulators and Change at Onset of CFRDs." -other hsa-mir-708 Cystic Fibrosis 27689251 "miR-146a, miR-155, miR-370, and miR-708 Are CFTR-Dependent, Predicted FOXO1 Regulators and Change at Onset of CFRDs." -other hsa-mir-122 Hepatitis C Virus Infection 27692039 Proposed update to the taxonomy of the genera Hepacivirus and Pegivirus within the Flaviviridae family. -other hsa-mir-195 Alzheimer Disease 27693395 MiR-195 dependent roles of mitofusin2 in the mitochondrial dysfunction of hippocampal neurons in SAMP8 mice. -other hsa-let-7a "Carcinoma, Hepatocellular" 27693636 Hepatitis B virus mRNAs functionally sequester let-7a and enhance hepatocellular carcinoma. -other hsa-mir-338 "Carcinoma, Hepatocellular" 27694002 Down-regulation of microRNA-338-3p promoted angiogenesis in hepatocellular carcinoma. -other hsa-mir-200 "Carcinoma, Lung" 27694892 ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis. -other hsa-mir-126 "Diabetes Mellitus, Type 2" 27696070 MicroRNA-126 and micro-/macrovascular complications of type 1 diabetes in the EURODIAB Prospective Complications Study. -other hsa-mir-494 "Leukemia, Myeloid, Acute" 27696394 MicroRNA-494 Activation Suppresses Bone Marrow Stromal Cell-Mediated Drug Resistance in Acute Myeloid Leukemia Cells. -other hsa-mir-133b "Carcinoma, Gastric" 27696637 MiR-133b inhibits growth of human gastric cancer cells by silencing pyruvate kinase muscle-splicer polypyrimidine tract-binding protein 1. -other hsa-mir-155 Systemic Lupus Erythematosus 27697141 Follicular T helper cells and IL-21 in rheumatic diseases. -other hsa-mir-21 Systemic Lupus Erythematosus 27697141 Follicular T helper cells and IL-21 in rheumatic diseases. -other hsa-mir-222 "Carcinoma, Breast" 27699665 miR-222 induces Adriamycin resistance in breast cancer through PTEN/Akt/p27kip1 pathway. -other hsa-mir-20b "Carcinoma, Esophageal" 27701465 "MicroRNA-20b (miR-20b) Promotes the Proliferation, Migration, Invasion, and Tumorigenicity in Esophageal Cancer Cells via the Regulation of Phosphatase and Tensin Homologue Expression." -other hsa-mir-129 Biliary Atresia 27706677 Effect of miR-29c and miR-129-5p on epithelial-mesenchymal transition in experimental biliary atresia mouse models. -other hsa-mir-29c Biliary Atresia 27706677 Effect of miR-29c and miR-129-5p on epithelial-mesenchymal transition in experimental biliary atresia mouse models. -other hsa-mir-137 Schizophrenia 27706734 Association between miR-137 polymorphism and risk of schizophrenia: a meta-analysis. -other hsa-mir-21 Myocardial Infarction 27708252 Effects of mir-21 on Cardiac Microvascular Endothelial Cells After Acute Myocardial Infarction in Rats: Role of Phosphatase and Tensin Homolog (PTEN)/Vascular Endothelial Growth Factor (VEGF) Signal Pathway. -other hsa-mir-133b "Carcinoma, Renal Cell" 27710896 miRNA-133b and miRNA-135a induce apoptosis via the JAK2/STAT3 signaling pathway in human renal carcinoma cells. -other hsa-mir-135a "Carcinoma, Renal Cell" 27710896 miRNA-133b and miRNA-135a induce apoptosis via the JAK2/STAT3 signaling pathway in human renal carcinoma cells. -other hsa-mir-155 "Diabetes Mellitus, Type 2" 27711113 MiR-155 Enhances Insulin Sensitivity by Coordinated Regulation of Multiple Genes in Mice. -other hsa-mir-877 Liver Injury 27713024 MicroRNA-877-5p is involved in the trovafloxacin-induced liver injury. -other hsa-mir-572 Neuroblastoma 27716787 Fluoxetine Increases the Expression of miR-572 and miR-663a in Human Neuroblastoma Cell Lines. -other hsa-mir-663a Neuroblastoma 27716787 Fluoxetine Increases the Expression of miR-572 and miR-663a in Human Neuroblastoma Cell Lines. -other hsa-mir-539 "Carcinoma, Hepatocellular" 27717846 microRNA-539 suppresses tumor growth and tumorigenesis and overcomes arsenic trioxide resistance in hepatocellular carcinoma. -other hsa-mir-155 "Carcinoma, Cervical" 27717891 The rs767649 polymorphism in the promoter of miR-155 contributes to the decreased risk for cervical cancer in a Chinese population. -other hsa-mir-378 Obesity 27721392 DNA methylation landscape of fat deposits and fatty acid composition in obese and lean pigs. -other hsa-mir-21 Epilepsy 27725160 Increased precursor microRNA-21 following status epilepticus can compete with mature microRNA-21 to alter translation. -other hsa-mir-21 "Carcinoma, Prostate" 27725205 "Methylated urolithin A, the modified ellagitannin-derived metabolite, suppresses cell viability of DU145 human prostate cancer cells via targeting miR-21." -other hsa-mir-34a "Carcinoma, Hepatocellular" 27725225 Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells. -other hsa-mir-140 Gout 27727249 microRNA-140 Inhibits Inflammation and Stimulates Chondrogenesis in a Model of Interleukin 1¦Â-induced Osteoarthritis. -other hsa-mir-30 "Carcinoma, Gastric" 27729002 miR-30 functions as an oncomiR in gastric cancer cells through regulation of P53-mediated mitochondrial apoptotic pathway. -other hsa-mir-372 "Carcinoma, Prostate" 27730751 Repression of MicroRNA-372 by Arsenic Sulphide Inhibits Prostate Cancer Cell Proliferation and Migration through Regulation of large tumour suppressor kinase 2. -other hsa-mir-224 Chronic Hepatitis B 27731343 MicroRNA-based diagnostic tools for advanced fibrosis and cirrhosis in patients with chronic hepatitis B and C. -other hsa-mir-224 Chronic Hepatitis C 27731343 MicroRNA-based diagnostic tools for advanced fibrosis and cirrhosis in patients with chronic hepatitis B and C. -other hsa-mir-221 Inflammation 27731391 Epithelial cell-derived microvesicles activate macrophages and promote inflammation via microvesicle-containing microRNAs. -other hsa-mir-940 "Carcinoma, Breast, Triple Negative" 27731867 MiR-940 Inhibited Cell Growth and Migration in Triple-Negative Breast Cancer. -other hsa-mir-9501 "Carcinoma, Lung, Non-Small-Cell" 27734264 "The novel miR-9501 inhibits cell proliferation, migration and activates apoptosis in non-small cell lung cancer." -other hsa-mir-6126 "Carcinoma, Ovarian" 27742688 Ubiquitous Release of Exosomal Tumor Suppressor miR-6126 from Ovarian Cancer Cells. -other hsa-mir-181c Heart Failure 27742689 Role of microRNA in metabolic shift during heart failure. -other hsa-mir-378 Heart Failure 27742689 Role of microRNA in metabolic shift during heart failure. -other hsa-mir-24 "Carcinoma, Gastric" 27743162 miR-24-3p Regulates Progression of Gastric Mucosal Lesions and Suppresses Proliferation and Invasiveness of N87 Via Peroxiredoxin 6. -other hsa-mir-223 "Carcinoma, Bladder" 27744452 Ginkgolide B Inhibits Human Bladder Cancer Cell Migration and Invasion Through MicroRNA-223-3p. -other hsa-mir-210 Preeclampsia 27746364 "Evaluation of MicroRNA-210 and Protein tyrosine phosphatase, non-receptor type 2 in Pre-eclampsia." -other hsa-mir-126 Atherosclerosis 27748840 Paeonol promotes microRNA-126 expression to inhibit monocyte adhesion to ox-LDL-injured vascular endothelial cells and block the activation of the PI3K/Akt/NF-¦ÊB pathway. -other hsa-mir-182 "Carcinoma, Ovarian" 27748882 Downregulation of DNMT3a expression increases miR-182-induced apoptosis of ovarian cancer through caspase-3?and?caspase-9-mediated apoptosis and DNA damage response. -other hsa-let-7a "Carcinoma, Cervical" 27748903 Let?7a suppresses cell proliferation via the TGF?¦Â/SMAD signaling pathway in cervical cancer. -other hsa-mir-100 "Carcinoma, Ovarian" 27748936 miR-100 resensitizes resistant epithelial ovarian cancer to cisplatin. -other hsa-mir-140 Infection [unspecific] 27749761 Microrna Expression Profiling of Macrophage Line Raw264.7 Infected by Candida Albicans. -other hsa-mir-29a Vascular Disease [unspecific] 27752152 Dynamic alteration of microRNA in high phosphorus induced calcification of vascular smooth muscle cell. -other hsa-mir-145 Multiple Sclerosis 27752929 miR-145 and miR20a-5p Potentially Mediate Pleiotropic Effects of Interferon-Beta Through Mitogen-Activated Protein Kinase Signaling Pathway in Multiple Sclerosis Patients. -other hsa-mir-20a Multiple Sclerosis 27752929 miR-145 and miR20a-5p Potentially Mediate Pleiotropic Effects of Interferon-Beta Through Mitogen-Activated Protein Kinase Signaling Pathway in Multiple Sclerosis Patients. -other hsa-mir-181b "Aortic Aneurysm, Abdominal" 27756793 MicroRNA-181b Controls Atherosclerosis and Aneurysms Through Regulation of TIMP-3 and Elastin. -other hsa-mir-21 Glioblastoma 27757032 Pluronic-based micelle encapsulation potentiates myricetin-induced cytotoxicity in human glioblastoma cells. -other hsa-mir-30a "Diabetes Mellitus, Type 2" 27758866 Mitochondrial Activity in Human White Adipocytes Is Regulated by the Ubiquitin Carrier Protein 9/microRNA-30a Axis. -other hsa-mir-376c "Squamous Cell Carcinoma, Head and Neck" 27760788 Dysregulation of RUNX2/Activin-A Axis upon miR-376c Downregulation Promotes Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma. -other hsa-mir-155 Chronic Hepatitis C 27765085 Differential Expression of MicroRNAs in Hepatitis C Virus-Mediated Liver Disease Between African Americans and Caucasians: Implications for Racial Health Disparities. -other hsa-mir-145 Pancreatic Adenocarcinoma 27765914 MiRNA-145 increases therapeutic sensibility to gemcitabine treatment of pancreatic adenocarcinoma cells. -other hsa-mir-145 "Squamous Cell Carcinoma, Lung" 27765924 Dual-strand tumor-suppressor microRNA-145 (miR-145-5p and miR-145-3p) coordinately targeted MTDH in lung squamous cell carcinoma. -other hsa-mir-214 Sezary Disease 27766406 "CD164 identifies CD4+ T cells highly expressing genes associated with malignancy in S¨¦zary syndrome: the S¨¦zary signature genes, FCRL3, Tox, and miR-214." -other hsa-mir-146a Colorectal Carcinoma 27769860 "microRNA-146a inhibits proliferation, migration and invasion of human cervical and colorectal cancer cells." -other hsa-mir-9 "Leukemia, Myeloid, Acute" 27770540 A minicircuitry of microRNA-9-1 and RUNX1-RUNX1T1 contributes to leukemogenesis in t(8;21) acute myeloid leukemia. -other hsa-mir-203 "Carcinoma, Colon" 27771718 Sodium Butyrate Upregulates miR-203 Expression to Exert Anti-Proliferation Effect on Colorectal Cancer Cells. -other hsa-let-7 "Carcinoma, Endometrial" 27775072 "Metformin acts by upregulating microRNA let-7 through AMPK activation, leading to degradation of H19 long noncoding RNA, which normally binds to and inactivates SAHH" -other hsa-mir-29b "Leukemia, Biphenotypic, Acute" 27775550 MicroRNA-29b mediates altered innate immune development in acute leukemia. -other hsa-mir-143 Atherosclerosis 27775792 miR-143 is involved in endothelial cell dysfunction through suppression of glycolysis and correlated with atherosclerotic plaques formation. -other hsa-mir-92b "Carcinoma, Lung, Non-Small-Cell" 27775799 Regulation of Twist in the metastasis of non-small cell lung cancer by miR-92b. -other hsa-mir-155 "Carcinoma, Thyroid, Papillary" 27777199 Expression of microRNA-155 in papillary thyroid carcinoma and its clinical significance. -other hsa-mir-29c Endometriosis 27778641 Progesterone Resistance in Endometriosis Is Modulated by the Altered Expression of MicroRNA-29c and FKBP4. -other hsa-mir-361 "Carcinoma, Lung, Non-Small-Cell" 27779659 "microRNA-361 targets Wilms' tumor 1 to inhibit the growth, migration and invasion of non-small-cell lung cancer cells." -other hsa-mir-129 "Carcinoma, Prostate" 27779679 miR-129 predicts prognosis and inhibits cell growth in human prostate carcinoma. -other hsa-mir-27a "Carcinoma, Breast" 27779715 miR-27a-mediated antiproliferative effects of metformin on the breast cancer cell line MCF-7. -other hsa-mir-106a Neoplasms [unspecific] 27780637 MiR-106a: Promising biomarker for cancer. -other hsa-mir-17 Neoplasms [unspecific] 27780637 MiR-106a: Promising biomarker for cancer. -other hsa-mir-7 "Leukemia, Myeloid, Acute" 27784745 Mutational Landscape and Gene Expression Patterns in Adult Acute Myeloid Leukemias with Monosomy 7 as a Sole Abnormality. -other hsa-let-7i Acute Ischemic Stroke 27784773 Leukocyte response is regulated by microRNA let7i in patients with acute ischemic stroke. -other hsa-let-7 "Carcinoma, Colon" 27789274 "H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-¦Â-Catenin Signaling in Colorectal Cancer." -other hsa-mir-206 Vascular Hypertrophy 27789288 Bladder overactivity involves overexpression of MicroRNA 132 and nerve growth factor. -other hsa-mir-130a Myocardial Infarction 27789328 Resveratrol increases microRNA-130a expression to promote angiogenesis and improve heart functions in mice after myocardial infarction. -other hsa-mir-126 Vascular Disease [unspecific] 27789478 MicroRNA-126a Directs Lymphangiogenesis Through Interacting With Chemokine and Flt4 Signaling in Zebrafish. -other hsa-mir-125b Tuberculosis 27789724 Downregulation of hsa-miR-337-3p and hsa-miR-125b-5p by miRNA sponges improved IL-23-mediated expansion of V¦Ã2V¦Ä2 T cells and restored the ability of these cells to produce anti-tuberculosis cytokines -other hsa-mir-337 Tuberculosis 27789724 Downregulation of hsa-miR-337-3p and hsa-miR-125b-5p by miRNA sponges improved IL-23-mediated expansion of V¦Ã2V¦Ä2 T cells and restored the ability of these cells to produce anti-tuberculosis cytokines -other hsa-mir-203a Gastric Cardia Adenocarcinoma 27791400 Downregulation of Potential Tumor Suppressor miR-203a by Promoter Methylation Contributes to the Invasiveness of Gastric Cardia Adenocarcinoma. -other hsa-mir-192 "Carcinoma, Colon" 27793841 Phospholipase D1 Acts through Akt/TopBP1 and RB1 to Regulate the E2F1-Dependent Apoptotic Program in Cancer Cells. -other hsa-mir-4465 "Carcinoma, Colon" 27793841 Phospholipase D1 Acts through Akt/TopBP1 and RB1 to Regulate the E2F1-Dependent Apoptotic Program in Cancer Cells. -other hsa-mir-489 "Carcinoma, Pancreatic" 27793842 KRAS/NF-¦ÊB/YY1/miR-489 Signaling Axis Controls Pancreatic Cancer Metastasis. -other hsa-mir-142 "Lymphoma, Burkitt" 27796281 Epstein-Barr Virus (EBV)-BamHI-A Rightward Transcript (BART)-6 and Cellular MicroRNA-142 Synergistically Compromise Immune Defense of Host Cells in EBV-Positive Burkitt Lymphoma. -other hsa-mir-155 IgA Nephropathy 27796698 MicroRNA-155-induced T lymphocyte subgroup drifting in IgA nephropathy. -other hsa-mir-146a Alzheimer Disease 27797173 Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in A¦Â-Mediated Microglial Inflammation. -other hsa-mir-21 "Carcinoma, Colon" 27798874 Prognostic Significance of MicroRNA-21 Expression in Patients with Unresectable Metastatic Colon Cancer. -other hsa-mir-324 "Carcinoma, Breast" 27798879 MicroRNA-324 in Human Cancer: miR-324-5p and miR-324-3p Have Distinct Biological Functions in Human Cancer. -other hsa-mir-193b "Carcinoma, Renal Cell" 27802451 MicroRNA 193b-3p as a predictive biomarker of chronic kidney disease in patients undergoing radical nephrectomy for renal cell carcinoma. -other hsa-mir-21 Ischemia-Reperfusion Injury 27804287 Fluorescent Nanocomposite for Visualizing Cross-Talk between MicroRNA-21 and Hydrogen Peroxide in Ischemia-Reperfusion Injury in Live Cells and In Vivo. -other hsa-mir-19b Heart Failure 27805004 miR-19b Regulates Ventricular Action Potential Duration in Zebrafish. -other hsa-mir-122 Chronic Hepatitis C 27805315 Inducing Hepatitis C Virus Resistance After Pig Liver Transplantation-A Proof of Concept of Liver Graft Modification Using Warm Ex Vivo Perfusion. -other hsa-mir-124 "Carcinoma, Cervical" 27806357 Virtues and Weaknesses of DNA Methylation as a Test for Cervical Cancer Prevention. -other hsa-mir-635 "Carcinoma, Lung, Non-Small-Cell" 27810784 The microRNA-635 suppresses tumorigenesis in non-small cell lung cancer. -other hsa-mir-17 "Carcinoma, Breast" 27811009 Penfluridol Represses Integrin Expression in Breast Cancer through Induction of Reactive Oxygen Species and Downregulation of Sp Transcription Factors. -other hsa-mir-20a "Carcinoma, Breast" 27811009 Penfluridol Represses Integrin Expression in Breast Cancer through Induction of Reactive Oxygen Species and Downregulation of Sp Transcription Factors. -other hsa-mir-27a "Carcinoma, Breast" 27811009 Penfluridol Represses Integrin Expression in Breast Cancer through Induction of Reactive Oxygen Species and Downregulation of Sp Transcription Factors. -other hsa-mir-129b "Carcinoma, Lung" 27813559 miR-129b suppresses cell proliferation in the human lung cancer cell lines A549 and H1299. -other hsa-mir-320 Melanoma 27816966 "HUR protects NONO from degradation by mir320, which is induced by p53 upon UV irradiation." -other hsa-mir-155 Biliary Atresia 27817193 Effect of microRNA-155 on the interferon-gamma signaling pathway in biliary atresia. -other hsa-mir-3658 "Carcinoma, Bladder" 27820650 Upregulation of miR-3658 in bladder cancer and tumor progression. -other hsa-let-7 "Carcinoma, Hepatocellular" 27821157 Let-7 inhibits self-renewal of hepatocellular cancer stem-like cells through regulating the epithelial-mesenchymal transition and the Wnt signaling pathway. -other hsa-mir-196b Glioma 27821299 Biomarkers related with seizure risk in glioma patients: A systematic review. -other hsa-mir-21 "Colitis, Ulcerative" 27824649 Downregulation of MicroRNA-21 in Colonic CD3+ T Cells in UC Remission. -other hsa-mir-126 Acute Brucellosis 27824867 MicroRNA Expression Patterns of CD8+ T Cells in Acute and Chronic Brucellosis. -other hsa-mir-4753 Acute Brucellosis 27824867 MicroRNA Expression Patterns of CD8+ T Cells in Acute and Chronic Brucellosis. -other hsa-mir-126 White Spot Syndrome Virus Infection 27825947 Characterization of microRNAs by deep sequencing in red claw crayfish Cherax quadricarinatus haematopoietic tissue cells after white spot syndrome virus infection. -other hsa-mir-184 White Spot Syndrome Virus Infection 27825947 Characterization of microRNAs by deep sequencing in red claw crayfish Cherax quadricarinatus haematopoietic tissue cells after white spot syndrome virus infection. -other hsa-mir-7 White Spot Syndrome Virus Infection 27825947 Characterization of microRNAs by deep sequencing in red claw crayfish Cherax quadricarinatus haematopoietic tissue cells after white spot syndrome virus infection. -other hsa-mir-206 Chondrosarcoma 27826039 Amphiregulin enhances VEGF-A production in human chondrosarcoma cells and promotes angiogenesis by inhibiting miR-206 via FAK/c-Src/PKC¦Ä pathway. -other hsa-mir-93 "Carcinoma, Endometrial" 27829043 MicroRNA-93 Promotes Epithelial-Mesenchymal Transition of Endometrial Carcinoma Cells. -other hsa-mir-155 Stroke 27829437 In vivo inhibition of miR-155 significantly alters post-stroke inflammatory response. -other hsa-mir-19a Myeloma 27830963 MicroRNA-19a functions as an oncogene by regulating PTEN/AKT/pAKT pathway in myeloma. -other hsa-mir-20b Myasthenia Gravis 27833920 miR-20b Inhibits T Cell Proliferation and Activation via NFAT Signaling Pathway in Thymoma-Associated Myasthenia Gravis. -other hsa-mir-125b Atherosclerosis 27835742 Silencing of CD40 in?vivo reduces progression of experimental atherogenesis through an NF-¦ÊB/miR-125b axis and reveals new potential mediators in the pathogenesis of atherosclerosis. -other hsa-mir-21 "Carcinoma, Breast" 27836600 A novel method for sensitive microRNA detection: Electropolymerization based doping. -other hsa-mir-221 Glioblastoma 27837435 Exosomal miR-221 targets DNM3 to induce tumor progression and temozolomide resistance in glioma. -other hsa-mir-200 Neoplasms [unspecific] 27837593 the full role of the miR-200 family in cancer progression and metastasis is not completely understood and seems to differ between different tumour types and different cellular backgrounds -other hsa-mir-152 "Carcinoma, Nasopharyngeal" 27840403 MicroRNA-152 Targets Phosphatase and Tensin Homolog to Inhibit Apoptosis and Promote Cell Migration of Nasopharyngeal Carcinoma Cells. -other hsa-mir-637 Glioma 27840895 Sevoflurane inhibits the migration and invasion of glioma cells by upregulating microRNA-637. -other hsa-mir-25 "Carcinoma, Hepatocellular" 27840896 Knockdown of miR-25 increases the sensitivity of liver cancer stem cells to TRAIL-induced apoptosis via PTEN/PI3K/Akt/Bad signaling pathway. -other hsa-mir-93 "Carcinoma, Breast, Triple Negative" 27840899 miR-93 inhibits the invasive potential of triple-negative breast cancer cells in vitro via protein kinase WNK1. -other hsa-mir-21 "Carcinoma, Ovarian" 27840916 Effects of celastrol on enhancing apoptosis of ovarian cancer cells via the downregulation of microRNA?21 and the suppression of the PI3K/Akt?NF?¦ÊB signaling pathway in an in?vitro model of ovarian carcinoma. -other hsa-mir-214 Osteosarcoma 27840941 Deregulated WWOX is involved in a negative feedback loop with microRNA-214-3p in osteosarcoma. -other hsa-mir-302a "Carcinoma, Colon" 27840990 MicroRNA-302a enhances 5-fluorouracil-induced cell death in human colon cancer cells. -other hsa-mir-208b Hepatitis [unspecific] 27841874 Hepatitis-C-virus-induced microRNAs dampen interferon-mediated antiviral signaling. -other hsa-mir-499a Hepatitis [unspecific] 27841874 Hepatitis-C-virus-induced microRNAs dampen interferon-mediated antiviral signaling. -other hsa-mir-135a Parkinson Disease 27842305 Involvement of microRNA-135a-5p in the Protective Effects of Hydrogen Sulfide Against Parkinson's Disease. -other hsa-mir-375 Neoplasms [unspecific] 27844328 Molecular Profiling of Thymoma and Thymic Carcinoma: Genetic Differences and Potential Novel Therapeutic Targets. -other hsa-mir-122 "Carcinoma, Hepatocellular" 27846390 ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5. -other hsa-mir-210 Spinal Cord Injuries 27847197 Synchrotron radiation micro-CT as a novel tool to evaluate the effect of agomir-210 in a rat spinal cord injury model. -other hsa-mir-29b Melanoma 27852308 Systems analysis identifies miR-29b regulation of invasiveness in melanoma. -other hsa-mir-219 Liver Cirrhosis 27855391 Suppression of MicroRNA-219-5p Activates Keratinocyte Growth Factor to Mitigate Severity of Experimental Cirrhosis. -other hsa-mir-34a Diabetic Nephropathy 27858840 Regulation of podocyte lesions in diabetic nephropathy via miR-34a in the Notch signaling pathway. -other hsa-mir-148a "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 27859417 RUNX3 inhibits laryngeal squamous cell carcinoma malignancy under the regulation of miR-148a-3p/DNMT1 axis. -other hsa-mir-455 Colon Neoplasms 27861461 MicroRNA-455-3p Inhibits Tumor Cell Proliferation and Induces Apoptosis in HCT116 Human Colon Cancer Cells. -other hsa-let-7 Hemoglobin Diseases 27861570 HMGA2 Moderately Increases Fetal Hemoglobin Expression in Human Adult Erythroblasts. -other hsa-mir-375 "Adenocarcinoma, Pancreatic Ductal" 27862697 ZFP36L2 promotes cancer cell aggressiveness and is regulated by antitumor microRNA-375 in pancreatic ductal adenocarcinoma. -other hsa-mir-139 "Carcinoma, Breast" 27864119 Role of miR-139 as a surrogate marker for tumor aggression in breast cancer. -other hsa-mir-146a Wound Inflammation 27864711 Mesenchymal stem cells-derived exosomal microRNAs contribute to wound inflammation. -other hsa-mir-181 Wound Inflammation 27864711 Mesenchymal stem cells-derived exosomal microRNAs contribute to wound inflammation. -other hsa-mir-21 Wound Inflammation 27864711 Mesenchymal stem cells-derived exosomal microRNAs contribute to wound inflammation. -other hsa-mir-124 Hematologic Neoplasms 27864740 Expression Levels of Warburg-Effect Related microRNAs Correlate with each Other and that of Histone Deacetylase Enzymes in Adult Hematological Malignancies with Emphasis on Acute Myeloid Leukemia. -other hsa-mir-125b Hematologic Neoplasms 27864740 Expression Levels of Warburg-Effect Related microRNAs Correlate with each Other and that of Histone Deacetylase Enzymes in Adult Hematological Malignancies with Emphasis on Acute Myeloid Leukemia. -other hsa-mir-155 Hematologic Neoplasms 27864740 Expression Levels of Warburg-Effect Related microRNAs Correlate with each Other and that of Histone Deacetylase Enzymes in Adult Hematological Malignancies with Emphasis on Acute Myeloid Leukemia. -other hsa-mir-23b Hematologic Neoplasms 27864740 Expression Levels of Warburg-Effect Related microRNAs Correlate with each Other and that of Histone Deacetylase Enzymes in Adult Hematological Malignancies with Emphasis on Acute Myeloid Leukemia. -other hsa-mir-26a Hematologic Neoplasms 27864740 Expression Levels of Warburg-Effect Related microRNAs Correlate with each Other and that of Histone Deacetylase Enzymes in Adult Hematological Malignancies with Emphasis on Acute Myeloid Leukemia. -other hsa-mir-378 Hematologic Neoplasms 27864740 Expression Levels of Warburg-Effect Related microRNAs Correlate with each Other and that of Histone Deacetylase Enzymes in Adult Hematological Malignancies with Emphasis on Acute Myeloid Leukemia. -other hsa-mir-708 Bipolar Disorder 27864917 Genetic variation in the miR-708 gene and its binding targets in bipolar disorder. -other hsa-mir-182 Acute Kidney Failure 27865759 miRNA-Coordinated Networks as Promising Therapeutic Targets for Acute Kidney Injury. -other hsa-mir-126 "Cardiomyopathy, Ischemic" 27866054 Comparison of miRNA signature versus conventional biomarkers before and after off-pump coronary artery bypass graft. -other hsa-mir-155 "Cardiomyopathy, Ischemic" 27866054 Comparison of miRNA signature versus conventional biomarkers before and after off-pump coronary artery bypass graft. -other hsa-mir-499 "Cardiomyopathy, Ischemic" 27866054 Comparison of miRNA signature versus conventional biomarkers before and after off-pump coronary artery bypass graft. -other hsa-mir-502 "Carcinoma, Gastric" 27866197 Rs56288038 (C/G) in 3'UTR of IRF-1 Regulated by MiR-502-5p Promotes Gastric Cancer Development. -other hsa-mir-188 Azoospermia 27868267 Reduced microRNA-188-3p expression contributes to apoptosis of spermatogenic cells in patients with azoospermia. -other hsa-mir-192 Ischemia-Reperfusion Injury 27870736 Lidocaine Administration Controls MicroRNAs Alterations Observed After Lung Ischemia-Reperfusion Injury. -other hsa-mir-182 Kidney Injury 27870928 miR-182-5p Inhibition Ameliorates Ischemic Acute Kidney Injury. -other hsa-mir-326 Glioblastoma 27871300 PI3 kinase pathway regulated miRNome in glioblastoma: identification of miR-326 as a tumour suppressor miRNA. -other hsa-let-7 "Carcinoma, Laryngeal" 27874955 Expression and significances of MiRNA Let-7 and HMGA2 in laryngeal carcinoma. -other hsa-mir-30a "Carcinoma, Gastric" 27876712 MiR-30a Decreases Multidrug Resistance (MDR) of Gastric Cancer Cells. -other hsa-mir-590 "Carcinoma, Colon" 27878255 Roles of mitochondrial transcription factor A and microRNA?590?3p in the development of colon cancer. -other hsa-mir-20b "Carcinoma, Colon" 27878272 miR-20b reduces 5-FU resistance by suppressing the ADAM9/EGFR signaling pathway in colon cancer. -other hsa-mir-375 "Squamous Cell Carcinoma, Tongue" 27878285 Trichostatin A increases radiosensitization of tongue squamous cell carcinoma via miR?375. -other hsa-mir-148a Obesity 27878286 Obesity?associated miR?148a is regulated by cytokines and adipokines via a transcriptional mechanism. -other hsa-mir-196a Lung Neoplasms 27880728 Analysis of miRNA profiles identified miR-196a as a crucial mediator of aberrant PI3K/AKT signaling in lung cancer cells. -other hsa-mir-21 "Carcinoma, Esophageal" 27885434 Evaluation of miR-21 and miR-375 as prognostic biomarkers in oesophageal cancer in high-risk areas in China. -other hsa-mir-375 "Carcinoma, Esophageal" 27885434 Evaluation of miR-21 and miR-375 as prognostic biomarkers in oesophageal cancer in high-risk areas in China. -other hsa-mir-99 Hepatitis B Virus Infection 27886437 The microRNA-99 family modulates hepatitis B virus replication by promoting IGF-1R/PI3K/Akt/mTOR/ULK1 signaling-induced autophagy. -other hsa-mir-18a Leukemia 27888798 miR-103 inhibits proliferation and sensitizes hemopoietic tumor cells for glucocorticoid-induced apoptosis. -other hsa-mir-20a Leukemia 27888798 miR-103 inhibits proliferation and sensitizes hemopoietic tumor cells for glucocorticoid-induced apoptosis. -other hsa-mir-124 "Squamous Cell Carcinoma, Oral" 27889233 Icaritin induces mitochondrial apoptosis by up-regulating miR-124 in human oral squamous cell carcinoma cells. -other hsa-mir-616 "Carcinoma, Lung" 27890917 Sulforaphane suppresses EMT and metastasis in human lung cancer through miR-616-5p-mediated GSK3¦Â/¦Â-catenin signaling pathways. -other hsa-mir-338 Schizophrenia 27892953 Thalamic miR-338-3p mediates auditory thalamocortical disruption and its late onset in models of 22q11.2 microdeletion. -other hsa-mir-128 Glioblastoma 27893811 The Inhibition of microRNA-128 on IGF-1-Activating mTOR Signaling Involves in Temozolomide-Induced Glioma Cell Apoptotic Death. -other hsa-mir-30b "Carcinoma, Hepatocellular" 27894814 Tanshinone IIA induced cell death via miR30b-p53-PTPN11/SHP2 signaling pathway in human hepatocellular carcinoma cells. -other hsa-mir-142 Wound Healing 27894934 MiR-142 Is Required for Staphylococcus aureus Clearance at Skin Wound Sites via Small GTPase-Mediated Regulation of the Neutrophil Actin Cytoskeleton. -other hsa-mir-210 Atherosclerosis 27895035 MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions. -other hsa-mir-122 "Carcinoma, Hepatocellular" 27895094 Crosstalk between microRNA-122 and FOX family genes in HepG2 cells. -other hsa-mir-18a Neuroblastoma 27895778 Regulatory network analysis of genes and microRNAs in human hepatoblastoma. -other hsa-mir-21 Leukemia 27895788 Effects of microRNA-21 on the biological functions of T-cell acute lymphoblastic lymphoma/leukemia. -other hsa-mir-451 Esophageal Neoplasms 27896643 A novel signaling role for miR-451 in esophageal tumor microenvironment and its contribution to tumor progression. -other hsa-mir-122 "Diabetes Mellitus, Type 2" 27899485 Circulating MicroRNA-122 Is Associated With the Risk of New-Onset Metabolic Syndrome and Type 2 Diabetes. -other hsa-mir-150 Leukemia 27899822 miR-150 exerts antileukemia activity in vitro and in vivo through regulating genes in multiple pathways. -other hsa-mir-152 Leiomyosarcoma 27900663 miR-152 down-regulation is associated with MET up-regulation in leiomyosarcoma and undifferentiated pleomorphic sarcoma. -other hsa-mir-31 "Carcinoma, Gastric" 27904131 MiR-31 Regulates Rho-Associated Kinase-Myosin Light Chain (ROCK-MLC) Pathway and Inhibits Gastric Cancer Invasion -other hsa-mir-221 "Carcinoma, Hepatocellular" 27904678 miR-221 promotes growth and invasion of hepatocellular carcinoma cells by constitutive activation of NF¦ÊB. -other hsa-mir-128 Cerebral Ischemia 27905005 MicroRNA-128-3p Protects Mouse Against Cerebral Ischemia Through Reducing p38¦Á Mitogen-Activated Protein Kinase Activity. -other hsa-mir-26a "Carcinoma, Hepatocellular" 27906498 "Sialyltransferase ST3GAL6 mediates the effect of microRNA-26a on cell growth, migration, and invasion in hepatocellular carcinoma through the protein kinase B/mammalian target of rapamycin pathway." -other hsa-mir-144 "Diabetes Mellitus, Type 2" 27906902 Comparison of Transcriptome Between Type 2 Diabetes Mellitus and Impaired Fasting Glucose. -other hsa-mir-192 "Diabetes Mellitus, Type 2" 27906902 Comparison of Transcriptome Between Type 2 Diabetes Mellitus and Impaired Fasting Glucose. -other hsa-mir-29a "Diabetes Mellitus, Type 2" 27906902 Comparison of Transcriptome Between Type 2 Diabetes Mellitus and Impaired Fasting Glucose. -other hsa-mir-145 Spinal Cord Injuries 27907012 The Signature of MicroRNA Dysregulation in Muscle Paralyzed by Spinal Cord Injury Includes Downregulation of MicroRNAs that Target Myostatin Signaling. -other hsa-mir-23a Spinal Cord Injuries 27907012 The Signature of MicroRNA Dysregulation in Muscle Paralyzed by Spinal Cord Injury Includes Downregulation of MicroRNAs that Target Myostatin Signaling. -other hsa-mir-21 Glioma 27909726 MicroRNA?21 promotes migration and invasion of glioma cells via activation of Sox2 and ¦Â?catenin signaling. -other hsa-mir-181a Vascular Disease [unspecific] 27911586 miRNA-181a/b Regulates Phenotypes of Vessel Smooth Muscle Cells Through Serum Response Factor. -other hsa-mir-181b Vascular Disease [unspecific] 27911586 miRNA-181a/b Regulates Phenotypes of Vessel Smooth Muscle Cells Through Serum Response Factor. -other hsa-mir-98 Inflammation 27913008 MicroRNA-98 plays a critical role in experimental myocarditis. -other hsa-mir-155 "Carcinoma, Hepatocellular" 27913196 NF-kB-regulated exosomal miR-155 promotes the inflammation associated with arsenite carcinogenesis. -other hsa-mir-155 Adenovirus Infection 27916071 The effect of curcumin on the expression of miR-155 to apoptosis and invasion of extravillus trophoblast cells treated by lipopolysaccharide. -other hsa-mir-34a Pain 27917453 "Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors." -other hsa-mir-200c Colorectal Carcinoma 27918105 "Resveratrol Inhibits Proliferation, Invasion, and Epithelial-Mesenchymal Transition by Increasing miR-200c Expression in HCT-116 Colorectal Cancer Cells." -other hsa-mir-497 Atherosclerosis 27918592 MicroRNA-497 Induces Apoptosis and Suppresses Proliferation via the Bcl-2/Bax-Caspase9-Caspase3 Pathway and Cyclin D2 Protein in HUVECs. -other hsa-mir-7 Colorectal Carcinoma 27919977 MicroRNA-7 Is Associated with Malignant Potential and Poor Prognosis in Human Colorectal Cancer. -other hsa-mir-33 Atherosclerosis 27920122 MicroRNA-33 Controls Adaptive Fibrotic Response in the Remodeling Heart by Preserving Lipid Raft Cholesterol. -other hsa-mir-328 "Carcinoma, Gastric" 27923017 Expression of microRNA-328 Functions as a Biomarker for Recurrence of Early Gastric Cancer (EGC) After Endoscopic Submucosal Dissection (ESD) by Modulating CD44. -other hsa-mir-126 Atherosclerosis 27923459 MicroRNAs in lipid metabolism and atherosclerosis. -other hsa-mir-33a Atherosclerosis 27923459 MicroRNAs in lipid metabolism and atherosclerosis. -other hsa-mir-92a Atherosclerosis 27923459 MicroRNAs in lipid metabolism and atherosclerosis. -other hsa-mir-29 Cardiovascular Diseases [unspecific] 27932253 Regulation of cyclin D1 by arsenic and microRNA inhibits adipogenesis. -other hsa-mir-29b Cardiovascular Diseases [unspecific] 27932253 Regulation of cyclin D1 by arsenic and microRNA inhibits adipogenesis. -other hsa-mir-550a Diabetes Mellitus 27935135 Micro RNA-550a interferes with vitamin D metabolism in peripheral B cells of patients with diabetes. -other hsa-mir-221 Liver Cirrhosis 27935974 Epigallocatechin-3-Gallate Upregulates miR-221 to Inhibit Osteopontin-Dependent Hepatic Fibrosis. -other hsa-mir-92a Cardiovascular Diseases [unspecific] 27936205 Hyperhomocysteinemia in ApoE-/- Mice Leads to Overexpression of Enhancer of Zeste Homolog 2 via miR-92a Regulation. -other hsa-mir-132 Intracerebral Hemorrhage 27940326 MicroRNA-132 attenuates neurobehavioral and neuropathological changes associated with intracerebral hemorrhage in mice. -other hsa-mir-221 "Carcinoma, Breast" 27940575 mda-7/IL-24 Mediates Cancer Cell-Specific Death via Regulation of miR-221 and the Beclin-1 Axis. -other hsa-mir-200 "Carcinoma, Biliary Tract" 27941621 Relevance of MicroRNA200 Family and MicroRNA205 for Epithelial to Mesenchymal Transition and Clinical Outcome in Biliary Tract Cancer Patients. -other hsa-mir-205 "Carcinoma, Biliary Tract" 27941621 Relevance of MicroRNA200 Family and MicroRNA205 for Epithelial to Mesenchymal Transition and Clinical Outcome in Biliary Tract Cancer Patients. -other hsa-mir-142 Autoimmune Diseases [unspecific] 27943367 Analysis of miR-146a and miR-142-3p as Potential Markers of Freshly Isolated or In Vitro-Expanded Human Treg cells. -other hsa-mir-146a Autoimmune Diseases [unspecific] 27943367 Analysis of miR-146a and miR-142-3p as Potential Markers of Freshly Isolated or In Vitro-Expanded Human Treg cells. -other hsa-mir-145 "Aortic Aneurysm, Abdominal" 27956160 MicroRNA-145 Mediates the Formation of Angiotensin II-Induced Murine Abdominal Aortic Aneurysm. -other hsa-mir-1271 Multiple Myeloma 27959416 MicroRNA-1271 inhibits proliferation and promotes apoptosis of multiple myeloma cells through inhibiting smoothened-mediated Hedgehog signaling pathway. -other hsa-mir-376c Gastric Neoplasms 27965982 hsa-miR-376c-3p Regulates Gastric Tumor Growth Both In Vitro and In Vivo. -other hsa-mir-205 "Squamous Cell Carcinoma, Esophageal" 27974696 Sp1-mediated transcriptional activation of miR-205 promotes radioresistance in esophageal squamous cell carcinoma. -other hsa-mir-9 Glioma 27975329 Density-Dependent Regulation of Glioma Cell Proliferation and Invasion Mediated by miR-9. -other hsa-mir-34a Diabetic Retinopathy 27977785 LGR4 Is a Direct Target of MicroRNA-34a and Modulates the Proliferation and Migration of Retinal Pigment Epithelial ARPE-19 Cells. -other hsa-mir-376a "Carcinoma, Ovarian" 27979415 MiR-376a promotion of proliferation and metastases in ovarian cancer -other hsa-mir-122 "Carcinoma, Hepatocellular" 27980102 Blocking the CCL2-CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model. -other hsa-mir-155 Inflammation 27981414 MicroRNA-155: a Novel Armamentarium Against Inflammatory Diseases. -other hsa-mir-760 "Carcinoma, Breast" 27981531 miR-760 mediates chemoresistance through inhibition of epithelial mesenchymal transition in breast cancer cells. -other hsa-mir-155 Human Immunodeficiency Virus Infection 27981723 MicroRNA-155 is a biomarker of T-cell activation and immune dysfunction in HIV-1-infected patients. -other hsa-mir-125a "Carcinoma, Hepatocellular" 27982429 MicroRNA-125a-5p Is a Downstream Effector of Sorafenib in Its Antiproliferative Activity Toward Human Hepatocellular Carcinoma Cells. -other hsa-mir-221 "Carcinoma, Hepatocellular" 27983537 Clinical potential of miRNA-221 as a novel prognostic biomarker for hepatocellular carcinoma. -other hsa-mir-210 Inflammation 27983913 Precise Regulation of miR-210 Is Critical for the Cellular Homeostasis Maintenance and Transplantation Efficacy Enhancement of Mesenchymal Stem Cells in Acute Liver Failure Therapy. -other hsa-mir-9 Rhabdomyosarcoma 27984116 MicroRNA and gene co-expression networks characterize biological and clinical behavior of rhabdomyosarcomas. -other hsa-mir-29a "Carcinoma, Breast" 27986463 Tamoxifen differentially regulates miR-29b-1 and miR-29a expression depending on endocrine-sensitivity in breast cancer cells. -other hsa-mir-29b "Carcinoma, Breast" 27986463 Tamoxifen differentially regulates miR-29b-1 and miR-29a expression depending on endocrine-sensitivity in breast cancer cells. -other hsa-mir-101 "Carcinoma, Pancreatic" 27988337 micorRNA-101 silences DNA-PKcs and sensitizes pancreatic cancer cells to gemcitabine. -other hsa-mir-125b Osteosarcoma 27990096 miR-125b and miR-100 Are Predictive Biomarkers of Response to Induction Chemotherapy in Osteosarcoma. -other hsa-mir-21 Neoplasms [unspecific] 27992999 Systematic Evaluation of Biophysical and Functional Characteristics of Selenomethylene-Locked Nucleic Acid-Mediated Inhibition of miR-21. -other hsa-mir-601 "Carcinoma, Pancreatic" 27993677 Identification of miR-601 as a novel regulator in the development of pancreatic cancer. -other hsa-mir-196a-2 Behcet Disease 27993883 Association of Reduced Heme Oxygenase-1 with Decreased MicroRNA-196a2 Expression in Peripheral Blood Mononuclear Cells of Patients with Intestinal Behcet's Disease. -other hsa-mir-34c Human Immunodeficiency Virus Infection 27993935 miRNA profiling of human naive CD4 T cells links miR-34c-5p to cell activation and HIV replication. -other hsa-mir-206 Coronary Artery Disease 27994218 MiR-206 Suppresses the Progression of Coronary Artery Disease by Modulating Vascular Endothelial Growth Factor (VEGF) Expression. -other hsa-mir-21 Leukemia 27995885 Targeted suppression of miRNA-21 inhibit K562 cells growth through PTEN-PI3K/AKT signaling pathway. -other hsa-mir-1 Viral Myocarditis 27997912 "Analysis of the Indicating Value of Cardiac Troponin I, Tumor Necrosis Factor-¦Á, Interleukin-18, Mir-1 and Mir-146b for Viral Myocarditis among Children." -other hsa-mir-146b Viral Myocarditis 27997912 "Analysis of the Indicating Value of Cardiac Troponin I, Tumor Necrosis Factor-¦Á, Interleukin-18, Mir-1 and Mir-146b for Viral Myocarditis among Children." -other hsa-mir-223 "Carcinoma, Hepatocellular" 27998765 MiR-223 modulates hepatocellular carcinoma cell proliferation through promoting apoptosis via the Rab1-mediated mTOR activation. -other hsa-mir-146a Inflammation 27998828 "we reported an anti-inflammatory effect of resveratrol and hydroxytyrosol at low, nutritionally relevant concentrations, involving the inhibition of granulocytes and monocytes activation, the modulation of miR-146a expression and the activation of Nrf2" -other hsa-mir-223 Inflammation 27999792 Inflammation Related MicroRNAs Are Modulated in Total Plasma and in Extracellular Vesicles from Rats with Chronic Ingestion of Sucrose. -other hsa-mir-22 Malignant Neoplasms [unspecific] 28000852 Molecular mechanisms and clinical applications of miR-22 in regulating malignant progression in human cancer -other hsa-mir-27a "Carcinoma, Thyroid" 28002594 "Effects of miR-27a upregulation on thyroid cancer cells migration, invasion, and angiogenesis." -other hsa-mir-200c "Carcinoma, Breast" 28003747 MicroRNA-200c delivered by solid lipid nanoparticles enhances the effect of paclitaxel on breast cancer stem cell. -other hsa-let-7 Neoplasms [unspecific] 28004230 "In Silico Mining of Conserved miRNAs of Indian Catfish Clarias batrachus (Linnaeus, 1758) from the Contigs, ESTs, and BAC End Sequences." -other hsa-mir-133 Neoplasms [unspecific] 28004230 "In Silico Mining of Conserved miRNAs of Indian Catfish Clarias batrachus (Linnaeus, 1758) from the Contigs, ESTs, and BAC End Sequences." -other hsa-mir-137 Neoplasms [unspecific] 28004230 "In Silico Mining of Conserved miRNAs of Indian Catfish Clarias batrachus (Linnaeus, 1758) from the Contigs, ESTs, and BAC End Sequences." -other hsa-mir-455 Neoplasms [unspecific] 28004230 "In Silico Mining of Conserved miRNAs of Indian Catfish Clarias batrachus (Linnaeus, 1758) from the Contigs, ESTs, and BAC End Sequences." -other hsa-mir-140 "Adenocarcinoma, Lung" 28005074 MiR-206 and miR-140 also suppressed lung adenocarcinoma cell metastasis in vitro and in vivo by regulating EMT-related factors -other hsa-mir-206 "Adenocarcinoma, Lung" 28005074 MiR-206 and miR-140 also suppressed lung adenocarcinoma cell metastasis in vitro and in vivo by regulating EMT-related factors -other hsa-mir-4286 Melanoma 28005927 Antiproliferative and Pro-Apoptotic Effects of MiR-4286 Inhibition in Melanoma Cells. -other hsa-mir-371 "Carcinoma, Prostate" 28005952 MicroRNA and Transcription Factor Gene Regulatory Network Analysis Reveals Key Regulatory Elements Associated with Prostate Cancer Progression. -other hsa-mir-512 "Carcinoma, Prostate" 28005952 MicroRNA and Transcription Factor Gene Regulatory Network Analysis Reveals Key Regulatory Elements Associated with Prostate Cancer Progression. -other hsa-mir-663 "Carcinoma, Prostate" 28005952 MicroRNA and Transcription Factor Gene Regulatory Network Analysis Reveals Key Regulatory Elements Associated with Prostate Cancer Progression. -other hsa-mir-665 "Carcinoma, Prostate" 28005952 MicroRNA and Transcription Factor Gene Regulatory Network Analysis Reveals Key Regulatory Elements Associated with Prostate Cancer Progression. -other hsa-mir-671 "Carcinoma, Prostate" 28005952 MicroRNA and Transcription Factor Gene Regulatory Network Analysis Reveals Key Regulatory Elements Associated with Prostate Cancer Progression. -other hsa-mir-21 Sepsis 28006751 miR-375 ameliorates sepsis by downregulating miR-21 level via inhibiting JAK2-STAT3 signaling. -other hsa-mir-375 Sepsis 28006751 miR-375 ameliorates sepsis by downregulating miR-21 level via inhibiting JAK2-STAT3 signaling. -other hsa-mir-215 Colorectal Carcinoma 28006930 Systemic administration of miRNA mimics by liposomal delivery system in animal model of colorectal carcinoma. -other hsa-mir-335 "Carcinoma, Breast" 28008602 MicroRNA-335-5p and -3p synergize to inhibit estrogen receptor alpha expression and promote tamoxifen resistance. -other hsa-mir-122 Chronic Hepatitis C 28008821 Cooperative enhancement of translation by two adjacent microRNA-122/Argonaute 2 complexes binding to the 5' untranslated region of hepatitis C virus RNA. -other hsa-let-7a "Carcinoma, Hepatocellular" 28012864 Germline and somatic DICER1 mutations in familial and sporadic liver tumors. -other hsa-mir-205 "Squamous Cell Carcinoma, Skin or Unspecific" 28013372 MiR-21 and miR-205 are induced in invasive cutaneous squamous cell carcinomas. -other hsa-mir-21 "Squamous Cell Carcinoma, Skin or Unspecific" 28013372 MiR-21 and miR-205 are induced in invasive cutaneous squamous cell carcinomas. -other hsa-mir-155 Cardiovascular Diseases [unspecific] 28018919 a recent clinical trial of Miravirsen targeting microRNA-122 sheds light on exploiting microRNA-155 as a novel target to develop effective therapeutic strategies for cardiovascular diseases in the near future -other hsa-mir-124 Myelodysplastic Syndromes 28024498 Reactivated Expression of MicroRNA-124 in Patients with Myelodysplastic Syndromes after Demethylating Therapy. -other hsa-mir-218 Gastrointestinal Neoplasms 28024574 miRNA-218-loaded carboxymethyl chitosan - Tocopherol nanoparticle to suppress the proliferation of gastrointestinal stromal tumor growth. -other hsa-mir-155 Stroke 28025572 Influence of miR-155 on Cell Apoptosis in Rats with Ischemic Stroke: Role of the Ras Homolog Enriched in Brain (Rheb)/mTOR Pathway. -other hsa-mir-200a Liver Cirrhosis 28025657 miR-200a controls hepatic stellate cell activation and fibrosis via SIRT1/Notch1 signal pathway. -other hsa-mir-1 Chronic Obstructive Pulmonary Disease 28025995 Prediction of key genes and miRNAs responsible for loss of muscle force in patients during an acute exacerbation of chronic obstructive pulmonary disease. -other hsa-mir-15a Chronic Obstructive Pulmonary Disease 28025995 Prediction of key genes and miRNAs responsible for loss of muscle force in patients during an acute exacerbation of chronic obstructive pulmonary disease. -other hsa-mir-16 Chronic Obstructive Pulmonary Disease 28025995 Prediction of key genes and miRNAs responsible for loss of muscle force in patients during an acute exacerbation of chronic obstructive pulmonary disease. -other hsa-mir-23a Chronic Obstructive Pulmonary Disease 28025995 Prediction of key genes and miRNAs responsible for loss of muscle force in patients during an acute exacerbation of chronic obstructive pulmonary disease. -other hsa-mir-9 Chronic Obstructive Pulmonary Disease 28025995 Prediction of key genes and miRNAs responsible for loss of muscle force in patients during an acute exacerbation of chronic obstructive pulmonary disease. -other hsa-mir-200a "Carcinoma, Esophageal" 28025999 miR-200a-3p promotes the proliferation of human esophageal cancer cells by post-transcriptionally regulating cytoplasmic collapsin response mediator protein-1. -other hsa-mir-9 Infection [unspecific] 28031262 Pseudomonas aeruginosa GroEL Stimulates Production of PTX3 by Activating the NF-¦ÊB Pathway and Simultaneously Downregulating MicroRNA-9. -other hsa-mir-15 Malignant Neoplasms [unspecific] 28032148 The relationship between platinum drug resistance and epithelial-mesenchymal transition. -other hsa-mir-186 Malignant Neoplasms [unspecific] 28032148 The relationship between platinum drug resistance and epithelial-mesenchymal transition. -other hsa-mir-210 Osteosarcoma 28032372 MicroRNA-210 is increased and it is required for dedifferentiation of osteosarcoma cell line. -other hsa-mir-192 Ischemia-Reperfusion Injury 28035621 Implications of dynamic changes in miR-192 expression in ischemic acute kidney injury. -other hsa-mir-210 Neoplasms [unspecific] 28036268 "Role of VHL, HIF1A and SDH on the expression of miR-210: Implications for tumoral pseudo-hypoxic fate." -other hsa-mir-143 Neoplasms [unspecific] 28038917 A positive feedback loop between GRP78 and VPS34 is critical for GRP78-mediated autophagy in cancer cells. -other hsa-mir-21 Systemic Lupus Erythematosus 28039018 Estrogen-regulated STAT1 activation promotes TLR8 expression to facilitate signaling via microRNA-21 in systemic lupus erythematosus. -other hsa-mir-192 Glioma 28039611 Alternative new mesenchymal stem cell source exerts tumor tropism through ALCAM and N-cadherin via regulation of microRNA-192 and -218. -other hsa-mir-218 Glioma 28039611 Alternative new mesenchymal stem cell source exerts tumor tropism through ALCAM and N-cadherin via regulation of microRNA-192 and -218. -other hsa-mir-1 "Leukemia, Myeloid, Acute" 28042875 "the PI3K/mTOR dual inhibitor BEZ235 effectively chemosensitizes AML cells via increasing miR-1-3p and subsequently down-regulating BAG4, EDN1 and ABCB1" -other hsa-mir-31 "Carcinoma, Nasopharyngeal" 28042945 Minicircle-oriP-miR-31 as a Novel EBNA1-Specific miRNA Therapy Approach for Nasopharyngeal Carcinoma. -other hsa-mir-190b "Carcinoma, Gastric" 28044223 MicroRNA-190b confers radio-sensitivity through negative regulation of Bcl-2 in gastric cancer cells. -other hsa-mir-34a "Carcinoma, Renal Cell" 28045889 Metformin Induces Growth Inhibition and Cell Cycle Arrest by Upregulating MicroRNA34a in Renal Cancer Cells. -other hsa-mir-182 Inflammation 28045967 Induction of Multiple miR-200/182 Members in the Brains of Mice Are Associated with Acute Herpes Simplex Virus 1 Encephalitis. -other hsa-mir-183 Inflammation 28045967 Induction of Multiple miR-200/182 Members in the Brains of Mice Are Associated with Acute Herpes Simplex Virus 1 Encephalitis. -other hsa-mir-210 Neoplasms [unspecific] 28046107 RNA Sequencing Reveals that Kaposi Sarcoma-Associated Herpesvirus Infection Mimics Hypoxia Gene Expression Signature. -other hsa-mir-214 "Carcinoma, Breast" 28051254 MiR-214 negatively regulates proliferation and WNT/¦Â-catenin signaling in breast cancer. -other hsa-mir-361 "Carcinoma, Lung, Non-Small-Cell" 28051257 Downregulation of miR-361-5p associates with aggressive clinicopathological features and unfavorable prognosis in non-small cell lung cancer. -other hsa-mir-379 "Carcinoma, Hepatocellular" 28051262 Bioinformatic identification of IGF1 as a hub gene in hepatocellular carcinoma (HCC) and in-vitro analysis of the chemosensitizing effect of miR-379 via suppressing the IGF1/IGF1R signaling pathway. -other hsa-mir-125a "Leukemia, Myeloid, Acute" 28053194 miR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism. -other hsa-mir-125b "Leukemia, Myeloid, Acute" 28053194 miR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism. -other hsa-mir-378 Renal Fibrosis 28053239 miR-378 reduces mesangial hypertrophy and kidney tubular fibrosis via MAPK signalling. -other hsa-mir-181a Chronic Hepatitis B 28053323 HBx promotes cell proliferation by disturbing the cross-talk between miR-181a and PTEN. -other hsa-mir-1292 Colorectal Carcinoma 28054337 Combined miRNA profiling and proteomics demonstrates that different miRNAs target a common set of proteins to promote colorectal cancer metastasis. -other hsa-mir-424 Colorectal Carcinoma 28054337 Combined miRNA profiling and proteomics demonstrates that different miRNAs target a common set of proteins to promote colorectal cancer metastasis. -other hsa-mir-503 Colorectal Carcinoma 28054337 Combined miRNA profiling and proteomics demonstrates that different miRNAs target a common set of proteins to promote colorectal cancer metastasis. -other hsa-mir-124 Ewing Sarcoma 28055964 miR-124 represses the mesenchymal features and suppresses metastasis in Ewing sarcoma. -other hsa-mir-504 Glioblastoma 28056026 "Integration of MicroRNA, mRNA, and Protein Expression Data for the Identification of Cancer-Related MicroRNAs." -other hsa-mir-152 "Carcinoma, Gastric" 28056089 Helicobacter Pylori Promote B7-H1 Expression by Suppressing miR-152 and miR-200b in Gastric Cancer Cells. -other hsa-mir-200b "Carcinoma, Gastric" 28056089 Helicobacter Pylori Promote B7-H1 Expression by Suppressing miR-152 and miR-200b in Gastric Cancer Cells. -other hsa-mir-497 "Adenocarcinoma, Lung" 28057758 Down-regulation of Claudin-2 Expression and Proliferation by Epigenetic Inhibitors in Human Lung Adenocarcinoma A549 Cells. -other hsa-mir-340 "Carcinoma, Gastric" 28057912 "miR-340 Inhibits Proliferation and Induces Apoptosis in Gastric Cancer Cell Line SGC-7901, Possibly via the AKT Pathway." -other hsa-let-7b Myocardial Infarction 28062497 Increased Proangiogenic Activity of Mobilized CD34+ Progenitor Cells of Patients With Acute ST-Segment-Elevation Myocardial Infarction: Role of Differential MicroRNA-378 Expression. -other hsa-mir-378 Myocardial Infarction 28062497 Increased Proangiogenic Activity of Mobilized CD34+ Progenitor Cells of Patients With Acute ST-Segment-Elevation Myocardial Infarction: Role of Differential MicroRNA-378 Expression. -other hsa-mir-9 "Carcinoma, Hepatocellular" 28062574 Loss of N-Acetylgalactosaminyltransferase-4 Orchestrates Oncogenic MicroRNA-9 in Hepatocellular Carcinoma. -other hsa-mir-181b "Adenocarcinoma, Pancreatic Ductal" 28064436 "MicroRNA-181b-5p, ETS1, and the c-Met pathway exacerbate the prognosis of pancreatic ductal adenocarcinoma after radiation therapy." -other hsa-mir-192 Lung Neoplasms 28067164 "pharmacological effects of curcumin in lung cancer are also mediated by modulation of several miRNAs, such as downregulation of oncogenic miR-21 and upregulation of oncosuppressive miR-192-5p and miR-215" -other hsa-mir-21 Lung Neoplasms 28067164 "pharmacological effects of curcumin in lung cancer are also mediated by modulation of several miRNAs, such as downregulation of oncogenic miR-21 and upregulation of oncosuppressive miR-192-5p and miR-215" -other hsa-mir-215 Lung Neoplasms 28067164 "pharmacological effects of curcumin in lung cancer are also mediated by modulation of several miRNAs, such as downregulation of oncogenic miR-21 and upregulation of oncosuppressive miR-192-5p and miR-215" -other hsa-mir-122 Chronic Hepatitis C 28067225 Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2. -other hsa-mir-16 "Carcinoma, Ovarian" 28067383 The functional consequences and prognostic value of dosage sensitivity in ovarian cancer. -other hsa-mir-98 "Carcinoma, Ovarian" 28067383 The functional consequences and prognostic value of dosage sensitivity in ovarian cancer. -other hsa-mir-34c "Carcinoma, Breast, Triple Negative" 28069384 Regulation of cancerous progression and epithelial-mesenchymal transition by miR-34c-3p via modulation of MAP3K2 signaling in triple-negative breast cancer cells. -other hsa-mir-133b "Squamous Cell Carcinoma, Esophageal" 28069586 SQLE induces epithelial-to-mesenchymal transition by regulating of miR-133b in esophageal squamous cell carcinoma. -other hsa-let-7 Neoplasms [unspecific] 28070818 "Entangling Relation of Micro RNA-let7, miRNA-200 and miRNA-125 with Various Cancers." -other hsa-mir-181 Leukemia 28072759 Induction of K562 Cell Apoptosis by As4S4 via Down-Regulating miR181. -other hsa-mir-221 Osteosarcoma 28074104 Bufalin Inhibits Proliferation and Induces Apoptosis in Osteosarcoma Cells by Downregulating MicroRNA-221. -other hsa-mir-124 "Carcinoma, Oral" 28077301 MiR-124 down-regulation is critical for cancer associated fibroblasts-enhanced tumor growth of oral carcinoma. -other hsa-mir-193b Polycystic Kidney Disease 28077374 "Expression of ErbB4 in vivo was increased in human ADPKD and Pkd1 cystic kidneys, both transcriptionally and posttranscriptionally by mir-193b-3p" -other hsa-mir-199a Cardiac Myocyte Injury 28077443 Single-Dose Intracardiac Injection of Pro-Regenerative MicroRNAs Improves Cardiac Function After Myocardial Infarction. -other hsa-mir-19a Hepatitis C Virus Infection 28077652 "Furthermore, we demonstrate the role of exosomal miR-19a in activation of the STAT3-TGF-¦Â pathway in HSC" -other hsa-mir-205 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 28078305 miR-375 and miR-205 Regulate the Invasion and Migration of Laryngeal Squamous Cell Carcinoma Synergistically via AKT-Mediated EMT. -other hsa-mir-375 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 28078305 miR-375 and miR-205 Regulate the Invasion and Migration of Laryngeal Squamous Cell Carcinoma Synergistically via AKT-Mediated EMT. -other hsa-mir-26a "Carcinoma, Hepatocellular" 28079894 MiR-26 enhances chemosensitivity and promotes apoptosis of hepatocellular carcinoma cells through inhibiting autophagy. -other hsa-mir-92a "Carcinoma, Cervical" 28081742 MicroRNA-92a Promotes Cell Proliferation in Cervical Cancer via Inhibiting p21 Expression and Promoting Cell Cycle Progression. -other hsa-mir-19a Asthma 28081849 Constitutive high expression of protein arginine methyltransferase 1 in asthmatic airway smooth muscle cells is caused by reduced microRNA-19a expression and leads to enhanced remodeling. -other hsa-mir-21 Infection [unspecific] 28083515 Genome-Wide Transcriptional and Post-transcriptional Regulation of Innate Immune and Defense Responses of Bovine Mammary Gland to Staphylococcus aureus. -other hsa-mir-223 Infection [unspecific] 28083515 Genome-Wide Transcriptional and Post-transcriptional Regulation of Innate Immune and Defense Responses of Bovine Mammary Gland to Staphylococcus aureus. -other hsa-mir-19b Liver Diseases [unspecific] 28083843 MicroRNA-19b Expression in Human Biliary Atresia Specimens and Its Role in BA-Related Fibrosis. -other hsa-mir-16 "Carcinoma, Thyroid, Papillary" 28085013 Expressions of miRNAs in papillary thyroid carcinoma and their associations with the clinical characteristics of PTC. -other hsa-mir-122 Chronic Hepatitis C 28087069 "Safety, tolerability, and antiviral effect of RG-101 in patients with chronic hepatitis C: a phase 1B, double-blind, randomised controlled trial." -other hsa-mir-24 Cholangiocarcinoma 28087162 miR-24 Inhibition Increases Menin Expression and Decreases Cholangiocarcinoma Proliferation. -other hsa-mir-143 Metabolic Syndrome 28088407 Far-off and close-up dry matter intake modulate indicators of immunometabolic adaptations to lactation in subcutaneous adipose tissue of pasture-based transition dairy cows. -other hsa-mir-29c "Carcinoma, Pancreatic" 28088520 Palmitic acid increases invasiveness of pancreatic cancer cells AsPC-1 through TLR4/ROS/NF-¦ÊB/MMP-9 signaling pathway. -other hsa-mir-21 "Adenocarcinoma, Lung" 28089356 Insertions and Deletions Target Lineage-Defining Genes in Human Cancers. -other hsa-mir-126 "Adenocarcinoma, Prostate" 28089917 "microRNAs and DICER1 are regulated by 1,25-dihydroxyvitamin D in prostate stroma." -other hsa-mir-154 "Adenocarcinoma, Prostate" 28089917 "microRNAs and DICER1 are regulated by 1,25-dihydroxyvitamin D in prostate stroma." -other hsa-mir-21 "Adenocarcinoma, Prostate" 28089917 "microRNAs and DICER1 are regulated by 1,25-dihydroxyvitamin D in prostate stroma." -other hsa-mir-125b Amyotrophic Lateral Sclerosis 28090150 M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b. -other hsa-mir-146a Sepsis 28090688 Exosomal miR-146a Contributes to the Enhanced Therapeutic Efficacy of Interleukin-1¦Â-Primed Mesenchymal Stem Cells Against Sepsis. -other hsa-mir-19b Heart Failure 28091585 MicroRNA-19b is a potential biomarker of increased myocardial collagen cross-linking in patients with aortic stenosis and heart failure. -other hsa-mir-1227 Glioma 28091986 miR-1227 may be associated with increased migration and miR-32 and miR-222 with decreased migration -other hsa-mir-222 Glioma 28091986 miR-1227 may be associated with increased migration and miR-32 and miR-222 with decreased migration -other hsa-mir-32 Glioma 28091986 miR-1227 may be associated with increased migration and miR-32 and miR-222 with decreased migration -other hsa-mir-29b Wound Healing 28092445 miR-29b promotes skin wound healing and reduces excessive scar formation by inhibition of the TGF-¦Â1/Smad/CTGF signaling pathway. -other hsa-mir-21 Breast Adenocarcinoma 28092843 "Moreover siRNA transfection had effects on breast adenocarcinoma cells and inhibits the migration (p<0.0001), proliferation (p<0.0001), cell cycle arrest (p=0.03) and induces apoptosis (p<0.0001) and reduces the expression of miR-21 (P=0.0014)" -other hsa-mir-4775 Colorectal Carcinoma 28095858 miR-4775 promotes colorectal cancer invasion and metastasis via the Smad7/TGF¦Â-mediated epithelial to mesenchymal transition. -other hsa-mir-221 "Carcinoma, Hepatocellular" 28096271 In Hepatocellular Carcinoma miR-221 Modulates Sorafenib Resistance through Inhibition of Caspase-3-Mediated Apoptosis. -other hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 28096685 The role of microRNA-21 in predicting brain metastases from non-small cell lung cancer. -other hsa-mir-34a Myelofibrosis 28098757 "the increased expression of miR-34a-5p in PMF HPCs could be important for the skewing of megakaryopoiesis and the production of monocytes, that are key players in BM fibrosis in PMF patients" -other hsa-mir-133b Colorectal Carcinoma 28098895 MicroRNA-133b is regulated by TAp63 while no gene mutation is present in colorectal cancer. -other hsa-mir-152 Colorectal Carcinoma 28098901 "after treatment with berberine and evodiamine for 24?h, respectively, increased expression of DNMT1, DNMT3A, DNMT3B and miR-152, miR-429, miR-29a was noted" -other hsa-mir-29a Colorectal Carcinoma 28098901 "after treatment with berberine and evodiamine for 24?h, respectively, increased expression of DNMT1, DNMT3A, DNMT3B and miR-152, miR-429, miR-29a was noted" -other hsa-mir-429 Colorectal Carcinoma 28098901 "after treatment with berberine and evodiamine for 24?h, respectively, increased expression of DNMT1, DNMT3A, DNMT3B and miR-152, miR-429, miR-29a was noted" -other hsa-mir-15a "Carcinoma, Renal Cell" 28098906 miR?15a?5p acts as an oncogene in renal cell carcinoma. -other hsa-mir-203 "Carcinoma, Hepatocellular" 28100026 miR-203 inhibits augmented proliferation and metastasis of hepatocellular carcinoma residual in the promoted regenerating liver. -other hsa-mir-142 Multiple Sclerosis 28100738 miR-142-3p Is a Key Regulator of IL-1¦Â-Dependent Synaptopathy in Neuroinflammation. -other hsa-mir-25 "Adenocarcinoma, Lung" 28101226 Evaluation of plasma microRNA levels to predict insensitivity of patients with advanced lung adenocarcinomas to pemetrexed and platinum. -other hsa-mir-146a "Carcinoma, Prostate" 28101571 Upregulation of miR-146a by YY1 depletion correlates with delayed progression of prostate cancer. -other hsa-mir-650 "Carcinoma, Breast" 28101578 A 22q11.2 amplification in the region encoding microRNA-650 correlates with the epithelial to mesenchymal transition in breast cancer primary cultures of Mexican patients. -other hsa-mir-126 Stroke 28101763 MiR-126 Affects Brain-Heart Interaction after Cerebral Ischemic Stroke. -other hsa-mir-125b Cervical Neoplasms 28102867 "Gene regulation of the DEGs also revealed important TFs and miRNAs such as ELF1, SRF, has-mir-125b-5p and has-mir-644a" -other hsa-mir-644a Cervical Neoplasms 28102867 "Gene regulation of the DEGs also revealed important TFs and miRNAs such as ELF1, SRF, has-mir-125b-5p and has-mir-644a" -other hsa-mir-146a "Carcinoma, Thyroid" 28103112 "Potassium Iodate Differently Regulates the Proliferation, Migration, and Invasion of Human Thyroid Cancer Cells via Modulating miR-146a." -other hsa-mir-133a Inflammatory Bowel Diseases 28104982 "miRNA-133a-UCP2 pathway regulates inflammatory bowel disease progress by influencing inflammation, oxidative stress and energy metabolism." -other hsa-mir-145 "Carcinoma, Bladder" 28106737 A Novel Combination RNAi toward Warburg Effect by Replacement with miR-145 and Silencing of PTBP1 Induces Apoptotic Cell Death in Bladder Cancer Cells. -other hsa-mir-130b Glioma 28107197 MTDH promotes glioma invasion through regulating miR-130b-ceRNAs. -other hsa-mir-142 Adrenal Cortex Neoplasms 28110695 "MEN1 and microRNAs: The link between sporadic pituitary, parathyroid and adrenocortical tumors" -other hsa-mir-24 Adrenal Cortex Neoplasms 28110695 "MEN1 and microRNAs: The link between sporadic pituitary, parathyroid and adrenocortical tumors" -other hsa-mir-382 Hemangioma 28112362 Downregulation of miR-382 by propranolol inhibits the progression of infantile hemangioma via the PTEN-mediated AKT/mTOR pathway. -other hsa-mir-145 "Carcinoma, Cervical" 28112371 MicroRNA-145 inhibits tumorigenesis and invasion of cervical cancer stem cells. -other hsa-mir-126 Intracerebral Hemorrhage 28112373 Protective role of microRNA-126 in intracerebral hemorrhage. -other hsa-mir-342 Glioma 28112756 Long noncoding RNA FTX is upregulated in gliomas and promotes proliferation and invasion of glioma cells by negatively regulating miR-342-3p. -other hsa-mir-200c "Carcinoma, Gastric" 28113080 "MicroRNA-200c binding to FN1 suppresses the proliferation, migration and invasion of gastric cancer cells." -other hsa-mir-1 Vascular Hypertrophy 28114137 Hydrogen Sulfide Protects Cardiomyocytes against Apoptosis in Ischemia/Reperfusion through MiR-1-Regulated Histone Deacetylase 4 Pathway. -other hsa-mir-26b Adenovirus Infection 28114818 Functional Screening Identifies Human miRNAs that Modulate Adenovirus Propagation in Prostate Cancer Cells. -other hsa-mir-122 "Carcinoma, Hepatocellular" 28114997 Targeted imaging and induction of apoptosis of drug-resistant hepatoma cells by miR-122-loaded graphene-InP nanocompounds. -other hsa-mir-183 "Adenocarcinoma, Lung" 28115792 Identification of Factors for the Preoperative Prediction of Tumour Subtype and Prognosis in Patients with T1 Lung Adenocarcinoma. -other hsa-mir-21 "Carcinoma, Breast" 28115844 Simultaneous delivery of anti-miR21 with doxorubicin prodrug by mimetic lipoprotein nanoparticles for synergistic effect against drug resistance in cancer cells. -other hsa-mir-155 Rheumatoid Arthritis 28118944 MicroRNA-155 contributes to enhanced resistance to apoptosis in monocytes from patients with rheumatoid arthritis. -other hsa-mir-508 Glioma 28121353 MiR-508-5p is a prognostic marker and inhibits cell proliferation and migration in glioma. -other hsa-mir-29b "Carcinoma, Cervical" 28122338 Chemotherapy-mediated miR-29b expression inhibits the invasion and angiogenesis of cervical cancer. -other hsa-mir-375 "Adenocarcinoma, Pancreatic Ductal" 28122349 The prognostic relevance of primary tumor location in patients undergoing resection for pancreatic ductal adenocarcinoma. -other hsa-mir-27a "Carcinoma, Laryngeal" 28122350 Transcriptional suppression of microRNA-27a contributes to laryngeal cancer differentiation via GSK-3¦Â-involved Wnt/¦Â-catenin pathway. -other hsa-mir-30e Atherosclerosis 28123167 "miR-30e in VSMCs exerted an anti-atherosclerosis effect via inhibiting proliferation and migration, and promoting apoptosis of VSMCs" -other hsa-mir-143 Bladder Neoplasms 28123579 miR-143 inhibits bladder cancer cell proliferation and enhances their sensitivity to gemcitabine by repressing IGF-1R signaling. -other hsa-mir-486 Lung Neoplasms 28124991 mir-660-p53-mir-486 Network: A New Key Regulatory Pathway in Lung Tumorigenesis. -other hsa-mir-660 Lung Neoplasms 28124991 mir-660-p53-mir-486 Network: A New Key Regulatory Pathway in Lung Tumorigenesis. -other hsa-mir-21 Pleural Mesothelioma 28125734 MiR-21-5p is suggested as novel regulator of MSLN with a possible functional role in cellular growth -other hsa-mir-126 "Carcinoma, Breast" 28125889 Micro RNA-126 coordinates cell behavior and signaling cascades according to characteristics of breast cancer cells. -other hsa-mir-133b Testicular Neoplasms 28126411 Perfluorooctanoic acid affects endocytosis involving clathrin light chain A and microRNA-133b-3p in mouse testes. -other hsa-mir-125b "Leukemia, Lymphocytic, Chronic, B-Cell" 28126961 miR-125b and miR-532-3p predict the efficiency of rituximab-mediated lymphodepletion in chronic lymphocytic leukemia patients. A French Innovative Leukemia Organization study. -other hsa-mir-532 "Leukemia, Lymphocytic, Chronic, B-Cell" 28126961 miR-125b and miR-532-3p predict the efficiency of rituximab-mediated lymphodepletion in chronic lymphocytic leukemia patients. A French Innovative Leukemia Organization study. -other hsa-mir-222 Cardiovascular Diseases [unspecific] 28127557 MiR-222 in Cardiovascular Diseases: Physiology and Pathology. -other hsa-mir-30c Diabetic Nephropathy 28127848 MiR-30c protects diabetic nephropathy by suppressing epithelial-to-mesenchymal transition in db/db mice. -other hsa-mir-155 Myocardial Infarction 28129114 Macrophage-Derived mir-155-Containing Exosomes Suppress Fibroblast Proliferation and Promote Fibroblast Inflammation during Cardiac Injury. -other hsa-mir-625 Melanoma 28129648 "microRNA-625 inhibits tumorigenicity by suppressing proliferation, migration and invasion in malignant melanoma." -other hsa-mir-155 Myelodysplastic Syndromes 28130497 Mechanisms of Impaired Neutrophil Migration by MicroRNAs in Myelodysplastic Syndromes. -other hsa-mir-34a Myelodysplastic Syndromes 28130497 Mechanisms of Impaired Neutrophil Migration by MicroRNAs in Myelodysplastic Syndromes. -other hsa-mir-204 "Carcinoma, Gastric" 28133610 Histological and Pathological Assessment of miR-204 and SOX4 Levels in Gastric Cancer Patients. -other hsa-mir-155 Neuroinflammation 28139244 MicroRNA 155 and viral-induced neuroinflammation. -other hsa-mir-483 Osteoarthritis 28139355 Intra-articular Delivery of Antago-miR-483-5p Inhibits Osteoarthritis by Modulating Matrilin 3 and Tissue Inhibitor of Metalloproteinase 2. -other hsa-mir-21 "Carcinoma, Bladder" 28139790 Formononetin inhibits human bladder cancer cell proliferation and invasiveness via regulation of miR-21 and PTEN. -other hsa-mir-125a Melanoma 28140520 MicroRNA-125a promotes resistance to BRAF inhibitors through suppression of the intrinsic apoptotic pathway. -other hsa-mir-126 Arteriosclerosis Obliterans 28143713 Intercellular transfer of miR-126-3p by endothelial microparticles reduces vascular smooth muscle cell proliferation and limits neointima formation by inhibiting LRP6. -other hsa-mir-34a Neuroblastoma 28145567 nanoparticles encapsulating miR©\34a and conjugated to a GD2 antibody facilitated tumor©\specific delivery following systemic administration into tumor bearing mice -other hsa-mir-135a Sepsis 28147298 MicroRNA-135a is up-regulated and aggravates myocardial depression in sepsis via regulating p38 MAPK/NF-¦ÊB pathway. -other hsa-mir-132 Alzheimer Disease 28148775 microRNA-132: a key noncoding RNA operating in the cellular phase of Alzheimer's disease. -other hsa-mir-126a Persistent Fetal Circulation Syndrome 28148930 MiR-126a-5p is involved in the hypoxia-induced endothelial-to-mesenchymal transition of neonatal pulmonary hypertension. -other hsa-mir-200b "Carcinoma, Breast" 28152297 miR-200b and miR-217 negatively regulated the expression of autophagy marker proteins -other hsa-mir-217 "Carcinoma, Breast" 28152297 miR-200b and miR-217 negatively regulated the expression of autophagy marker proteins -other hsa-mir-10b Glioblastoma 28153089 Genome Editing Reveals Glioblastoma Addiction to MicroRNA-10b. -other hsa-mir-24 "Carcinoma, Prostate" 28157714 The role of miR-24 as a race related genetic factor in prostate cancer. -other hsa-mir-30a "Carcinoma, Lung, Non-Small-Cell" 28158983 CD73/NT5E is a target of miR-30a-5p and plays an important role in the pathogenesis of non-small cell lung cancer. -other hsa-let-7b Cardiovascular Diseases [unspecific] 28159509 Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis. -other hsa-mir-598 "Carcinoma, Colon" 28161537 miR-598 inhibits metastasis in colorectal cancer by suppressing JAG1/Notch2 pathway stimulating EMT. -other hsa-mir-155 Neoplasms [unspecific] 28162271 Nitric Oxide: Genomic Instability And Synthetic Lethality. -other hsa-mir-200 "Carcinoma, Colon" 28163188 Transcriptional repression of miR-200 family members by Nanog in colon cancer cells induces epithelial-mesenchymal transition (EMT). -other hsa-mir-200b "Carcinoma, Colon" 28163188 Transcriptional repression of miR-200 family members by Nanog in colon cancer cells induces epithelial-mesenchymal transition (EMT). -other hsa-mir-200c "Carcinoma, Colon" 28163188 Transcriptional repression of miR-200 family members by Nanog in colon cancer cells induces epithelial-mesenchymal transition (EMT). -other hsa-mir-29b Lung Neoplasms 28164574 Expression and Function Analysis of MicroRNA-29b in Xuanwei Lung Cancer. -other hsa-mir-143 Aortic Aneurysm 28167124 P38 MAPK Signaling Pathway Mediates Angiotensin II-Induced miR143/145 Gene Cluster Downregulation during Aortic Dissection Formation. -other hsa-mir-145 Aortic Aneurysm 28167124 P38 MAPK Signaling Pathway Mediates Angiotensin II-Induced miR143/145 Gene Cluster Downregulation during Aortic Dissection Formation. -other hsa-mir-29a Fatty Liver [unspecific] 28167804 miR-29a modulates SCD expression and is regulated in response to a saturated fatty acid diet in juvenile genetically improved farmed tilapia (Oreochromis niloticus). -other hsa-mir-21 Myocardial Infarction 28170197 Enhanced Cardioprotection by Human Endometrium Mesenchymal Stem Cells Driven by Exosomal MicroRNA-21. -other hsa-mir-146b Diabetic Retinopathy 28170537 Adenosine Deaminase-2-Induced Hyperpermeability in Human Retinal Vascular Endothelial Cells Is Suppressed by MicroRNA-146b-3p. -other hsa-mir-1285 Wound Healing 28175294 miRNAs that associate with conjunctival inflammation and ocular Chlamydia trachomatis infection do not predict progressive disease. -other hsa-mir-147b Wound Healing 28175294 miRNAs that associate with conjunctival inflammation and ocular Chlamydia trachomatis infection do not predict progressive disease. -other hsa-mir-155 Wound Healing 28175294 miRNAs that associate with conjunctival inflammation and ocular Chlamydia trachomatis infection do not predict progressive disease. -other hsa-mir-184 Wound Healing 28175294 miRNAs that associate with conjunctival inflammation and ocular Chlamydia trachomatis infection do not predict progressive disease. -other hsa-mir-214 "Carcinoma, Ovarian" 28175963 Curcumin suppresses cisplatin resistance development partly via modulating extracellular vesicle-mediated transfer of MEG3 and miR-214 in ovarian cancer. -other hsa-mir-21 Colon Neoplasms 28176652 Mechanisms for the Inhibition of Colon Cancer Cells by Sulforaphane through Epigenetic Modulation of MicroRNA-21 and Human Telomerase Reverse Transcriptase (hTERT) Down-regulation. -other hsa-mir-944 "Carcinoma, Endometrial" 28178620 miR-944 acts as a prognostic marker and promotes the tumor progression in endometrial cancer. -other hsa-mir-17 "Carcinoma, Breast" 28178652 STAT3 is required for MiR-17-5p-mediated sensitization to chemotherapy-induced apoptosis in breast cancer cells. -other hsa-mir-191 Glioblastoma 28178667 "Anti-GD2-ch14.18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patient-derived GBM tumor cells." -other hsa-mir-122 "Carcinoma, Hepatocellular" 28179291 Synergistic Inhibitory Effect of Traditional Chinese Medicine Astragaloside IV and Curcumin on Tumor Growth and Angiogenesis in an Orthotopic Nude-Mouse Model of Human Hepatocellular Carcinoma. -other hsa-mir-100 Infection [unspecific] 28181552 MicroRNA-100 is involved in shrimp immune response to white spot syndrome virus (WSSV) and Vibrio alginolyticus infection. -other hsa-mir-216 Acute Pancreatitis 28183420 Circulating microRNA 216 as a Marker for the Early Identification of Severe Acute Pancreatitis. -other hsa-mir-183 Glioma 28184912 "Interaction between transcription factors PAX6/PAX6-5a and specific members of miR-183-96-182 cluster, may contribute to glioma progression in glioblastoma cell lines." -other hsa-mir-365 "Carcinoma, Hepatocellular" 28184920 miR-365 targets ADAM10 and suppresses the cell growth and metastasis of hepatocellular carcinoma. -other hsa-mir-181a "Leukemia, Lymphoblastic, Acute" 28184923 "miR-181a-5p, an inducer of Wnt-signaling, facilitates cell proliferation in acute lymphoblastic leukemia." -other hsa-mir-34a "Diabetes Mellitus, Type 1" 28185128 Effects of TRPM7/miR-34a Gene Silencing on Spatial Cognitive Function and Hippocampal Neurogenesis in Mice with Type 1 Diabetes Mellitus. -other hsa-mir-29b Neoplasms [unspecific] 28185889 MicroRNA hsa-miR-29b potentiates etoposide toxicity in HeLa cells via down-regulation of Mcl-1. -other hsa-mir-196b Pancreatic Neoplasms 28186267 MicroRNA-196b is an independent prognostic biomarker in patients with pancreatic cancer. -other hsa-mir-375 Colorectal Carcinoma 28186962 microRNA-375 inhibits colorectal cancer cells proliferation by downregulating JAK2/STAT3 and MAP3K8/ERK signaling pathways. -other hsa-mir-29a "Carcinoma, Breast" 28186968 XIAP 3'-untranslated region as a ceRNA promotes FSCN1 function in inducing the progression of breast cancer by binding endogenous miR-29a-5p. -other hsa-let-7a Vascular Hypertrophy 28187784 Let-7a-transfected mesenchymal stem cells ameliorate monocrotaline-induced pulmonary hypertension by suppressing pulmonary artery smooth muscle cell growth through STAT3-BMPR2 signaling. -other hsa-mir-210 Inflammation 28188219 Distinct Effects of miR-210 Reduction on Neurogenesis: Increased Neuronal Survival of Inflammation But Reduced Proliferation Associated with Mitochondrial Enhancement. -other hsa-mir-498 "Squamous Cell Carcinoma, Esophageal" 28188753 MiR-498 in esophageal squamous cell carcinoma: clinicopathological impacts and functional interactions. -other hsa-mir-29b Crohn Disease 28190086 MCL-1 is modulated in Crohn's disease fibrosis by miR-29b via IL-6 and IL-8. -other hsa-mir-221 "Carcinoma, Breast" 28191469 RNA-Binding Protein Dnd1 Promotes Breast Cancer Apoptosis by Stabilizing the Bim mRNA in a miR-221 Binding Site. -other hsa-mir-30a Glioma 28192116 PRRT2 inhibits the proliferation of glioma cells by modulating unfolded protein response pathway. -other hsa-mir-21 Colorectal Carcinoma 28192117 NR2F2 inhibits Smad7 expression and promotes TGF-¦Â-dependent epithelial-mesenchymal transition of CRC via transactivation of miR-21. -other hsa-mir-346 Graves Disease 28192819 MiR-346 and TRAb as Predicative Factors for Relapse in Graves' Disease Within One Year. -other hsa-mir-301a "Carcinoma, Colon" 28193514 MicroRNA 301A Promotes Intestinal Inflammation and Colitis-Associated Cancer Development by Inhibiting BTG1. -other hsa-mir-22 Preeclampsia 28193709 Testosterone Represses Estrogen Signaling by Upregulating miR-22: A Mechanism for Imbalanced Steroid Hormone Production in Preeclampsia. -other hsa-mir-34b Melanoma 28194372 MiR-34b-5p Suppresses Melanoma Differentiation-Associated Gene 5 (MDA5) Signaling Pathway to Promote Avian Leukosis Virus Subgroup J (ALV-J)-Infected Cells Proliferaction and ALV-J Replication. -other hsa-mir-125a Neoplasms [unspecific] 28197019 Inflammation and Cancer: Extra- and Intracellular Determinants of Tumor-Associated Macrophages as Tumor Promoters. -other hsa-mir-146a Neoplasms [unspecific] 28197019 Inflammation and Cancer: Extra- and Intracellular Determinants of Tumor-Associated Macrophages as Tumor Promoters. -other hsa-mir-155 Neoplasms [unspecific] 28197019 Inflammation and Cancer: Extra- and Intracellular Determinants of Tumor-Associated Macrophages as Tumor Promoters. -other hsa-mir-223 Neoplasms [unspecific] 28197019 Inflammation and Cancer: Extra- and Intracellular Determinants of Tumor-Associated Macrophages as Tumor Promoters. -other hsa-mir-511 Neoplasms [unspecific] 28197019 Inflammation and Cancer: Extra- and Intracellular Determinants of Tumor-Associated Macrophages as Tumor Promoters. -other hsa-mir-31 Lung Neoplasms 28197369 The transcriptome of lung tumor-infiltrating dendritic cells reveals a tumor-supporting phenotype and a microRNA signature with negative impact on clinical outcome. -other hsa-mir-21 Cholangiocarcinoma 28197636 miR-21 and KLF4 jointly augment epithelial?mesenchymal transition via the Akt/ERK1/2 pathway. -other hsa-mir-155 "Adenocarcinoma, Pancreatic Ductal" 28198398 MicroRNA-155 Controls Exosome Synthesis and Promotes Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma. -other hsa-mir-185 Stroke 28199366 MicroRNAs regulating cluster of differentiation 46 (CD46) in cardioembolic and non-cardioembolic stroke. -other hsa-mir-19a Stroke 28199366 MicroRNAs regulating cluster of differentiation 46 (CD46) in cardioembolic and non-cardioembolic stroke. -other hsa-mir-20a Stroke 28199366 MicroRNAs regulating cluster of differentiation 46 (CD46) in cardioembolic and non-cardioembolic stroke. -other hsa-mir-374b Stroke 28199366 MicroRNAs regulating cluster of differentiation 46 (CD46) in cardioembolic and non-cardioembolic stroke. -other hsa-mir-221 "Carcinoma, Breast" 28202520 Evolution of Cancer Stem-like Cells in Endocrine-Resistant Metastatic Breast Cancers Is Mediated by Stromal Microvesicles. -other hsa-mir-21 Glioma 28208619 "AKT Axis, miR-21, and RECK Play Pivotal Roles in Dihydroartemisinin Killing Malignant Glioma Cells." -other hsa-mir-17 Celiac Disease 28208686 Identification of Autophagy-Related Genes and Their Regulatory miRNAs Associated with Celiac Disease in Children. -other hsa-mir-30a Celiac Disease 28208686 Identification of Autophagy-Related Genes and Their Regulatory miRNAs Associated with Celiac Disease in Children. -other hsa-mir-132 Inflammation 28209997 Antisense miR-132 blockade via the AChE-R splice variant mitigates cortical inflammation. -other hsa-mir-375 "Squamous Cell Carcinoma, Lung" 28214218 Implication of downregulation and prospective pathway signaling of microRNA-375 in lung squamous cell carcinoma. -other hsa-mir-29b Cerebral Aneurysm 28214880 MiR-29b Downregulation Induces Phenotypic Modulation of Vascular Smooth Muscle Cells: Implication for Intracranial Aneurysm Formation and Progression to Rupture. -other hsa-mir-7 "Carcinoma, Ovarian" 28216373 TWEAK-stimulated macrophages inhibit metastasis of epithelial ovarian cancer via exosomal shuttling of microRNA. -other hsa-mir-21 Leukemia 28218044 Leukemia microvesicles affect healthy hematopoietic stem cells. -other hsa-mir-29a Leukemia 28218044 Leukemia microvesicles affect healthy hematopoietic stem cells. -other hsa-mir-18a "Carcinoma, Hepatocellular" 28219903 MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer. -other hsa-mir-223 "Carcinoma, Bladder" 28222670 MicroRNA-223-3p inhibits human bladder cancer cell migration and invasion. -other hsa-mir-137 Neuroblastoma 28223126 Targeted inhibition of HDAC8 increases the doxorubicin sensitivity of neuroblastoma cells via up regulation of miR-137. -other hsa-mir-125b "Carcinoma, Endometrial" 28225751 Proliferation and migration capability of endometrial carcinoma cells were detected after transfection of endometrial carcinoma cells with mir-125b mimic -other hsa-mir-100 "Carcinoma, Bladder" 28229968 Cytotoxic and toxicogenomic effects of silibinin in bladder cancer cells with different TP53 status. -other hsa-mir-203 "Carcinoma, Bladder" 28229968 Cytotoxic and toxicogenomic effects of silibinin in bladder cancer cells with different TP53 status. -other hsa-mir-7 "Carcinoma, Lung, Non-Small-Cell" 28229971 Breviscapine suppresses the growth of non-small cell lung cancer by enhancing microRNA-7 expression. -other hsa-mir-98 "Carcinoma, Breast" 28232182 SNHG16 contributes to breast cancer cell migration by competitively binding miR-98 with E2F5. -other hsa-mir-181a Machado-Joseph Disease 28236575 Unravelling Endogenous MicroRNA System Dysfunction as a New Pathophysiological Mechanism in Machado-Joseph Disease. -other hsa-mir-494 Machado-Joseph Disease 28236575 Unravelling Endogenous MicroRNA System Dysfunction as a New Pathophysiological Mechanism in Machado-Joseph Disease. -other hsa-mir-9 Machado-Joseph Disease 28236575 Unravelling Endogenous MicroRNA System Dysfunction as a New Pathophysiological Mechanism in Machado-Joseph Disease. -other hsa-mir-21 Colorectal Carcinoma 28236743 Direct binding of microRNA-21 pre-element with Regorafenib: An alternative mechanism for anti-colorectal cancer chemotherapy -other hsa-mir-185 "Carcinoma, Hepatocellular" 28240051 MicroRNA-185 induces potent autophagy via AKT signaling in hepatocellular carcinoma. -other hsa-mir-210 Neoplasms [unspecific] 28240549 Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit. -other hsa-mir-30d "Carcinoma, Prostate" 28241827 MicroRNA-30d promotes angiogenesis and tumor growth via MYPT1/c-JUN/VEGFA pathway and predicts aggressive outcome in prostate cancer. -other hsa-mir-142 "Carcinoma, Hepatocellular" 28243631 Identifying microRNA panels specifically associated with hepatocellular carcinoma and its different etiologies. -other hsa-mir-135b Multiple Myeloma 28245421 "Compared with those of the normal ones, exosomes in MM have less miR-15a and/or more miR-135b and miR-21" -other hsa-mir-15a Multiple Myeloma 28245421 "Compared with those of the normal ones, exosomes in MM have less miR-15a and/or more miR-135b and miR-21" -other hsa-mir-21 Multiple Myeloma 28245421 "Compared with those of the normal ones, exosomes in MM have less miR-15a and/or more miR-135b and miR-21" -other hsa-mir-200 "Carcinoma, Ovarian" 28245631 Role of Nerve Growth Factor (NGF) and miRNAs in Epithelial Ovarian Cancer. -other hsa-mir-23b "Carcinoma, Ovarian" 28245631 Role of Nerve Growth Factor (NGF) and miRNAs in Epithelial Ovarian Cancer. -other hsa-mir-17 Leukemia 28247308 Differential Maturation of miR-17?~?92 Cluster Members in Human Cancer Cell Lines. -other hsa-mir-20a Leukemia 28247308 Differential Maturation of miR-17?~?92 Cluster Members in Human Cancer Cell Lines. -other hsa-mir-92a Leukemia 28247308 Differential Maturation of miR-17?~?92 Cluster Members in Human Cancer Cell Lines. -other hsa-mir-210 Heart Failure 28249798 "Mesenchymal stem cells-derived extracellular vesicles, via miR-210, improve infarcted cardiac function by promotion of angiogenesis." -other hsa-mir-126 Human Immunodeficiency Virus Infection 28250134 MicroRNA miR-126-5p Enhances the Inflammatory Responses of Monocytes to Lipopolysaccharide Stimulation by Suppressing Cylindromatosis in Chronic HIV-1 Infection. -other hsa-mir-660 "Carcinoma, Breast" 28252173 Inhibition of miR-660-5p expression suppresses tumor development and metastasis in human breast cancer. -other hsa-mir-126 Cardiovascular Diseases [unspecific] 28253326 Prevention of neointimal formation using miRNA-126-containing nanoparticle-conjugated stents in a rabbit model. -other hsa-mir-423 "Carcinoma, Gastric" 28254439 The microRNA-423-3p-Bim Axis Promotes Cancer Progression and Activates Oncogenic Autophagy in Gastric Cancer. -other hsa-mir-150 Atherosclerosis 28254813 MicroRNA-150 Modulates Ischemia-Induced Neovascularization in Atherosclerotic Conditions. -other hsa-mir-200c Lung Fibrosis 28255128 Recent advances in miR-200c and fibrosis in organs. -other hsa-mir-195 Colorectal Carcinoma 28255246 miR-195 enhances the radiosensitivity of colorectal cancer cells by suppressing CARM1. -other hsa-mir-155 Neoplasms [unspecific] 28256712 Oncogenic role of microRNA-155 in mycosis fungoides: an in vitro and xenograft mouse model study. -other hsa-mir-138 "Carcinoma, Hepatocellular" 28258280 HCV core inhibits hepatocellular carcinoma cell replicative senescence through downregulating microRNA-138 expression. -other hsa-mir-155 "Carcinoma, Colon" 28259135 "miR-155 is positively regulated by CBX7 in mouse embryonic fibroblasts and colon carcinomas, and targets the KRAS oncogene." -other hsa-mir-30b "Carcinoma, Renal Cell" 28259953 Identification of miR?30b as an oncogene in renal cell carcinoma. -other hsa-mir-34a Parkinson Disease 28259991 The involvement of Eag1 potassium channels and miR-34a in rotenone-induced death of dopaminergic SH-SY5Y cells. -other hsa-mir-197 "Lymphoma, Burkitt" 28259992 EBV?BART?6?3p and cellular microRNA?197 compromise the immune defense of host cells in EBV?positive Burkitt lymphoma. -other hsa-mir-145 "Osteoporosis, Postmenopausal" 28260003 Estrogen stimulates osteoprotegerin expression via the suppression of miR-145 expression in MG-63 cells. -other hsa-mir-195 "Carcinoma, Renal Cell" 28260025 Identification of miR?195?3p as an oncogene in RCC. -other hsa-mir-149 Crohn Disease 28260036 Comprehensive bioinformatics analyses of Crohn's disease. -other hsa-mir-4447 Crohn Disease 28260036 Comprehensive bioinformatics analyses of Crohn's disease. -other hsa-mir-106a Parkinson Disease 28260060 Bioinformatics analysis on the differentiation of bone mesenchymal stem cells into osteoblasts and adipocytes. -other hsa-mir-203 Parkinson Disease 28260060 Bioinformatics analysis on the differentiation of bone mesenchymal stem cells into osteoblasts and adipocytes. -other hsa-mir-376a Parkinson Disease 28260060 Bioinformatics analysis on the differentiation of bone mesenchymal stem cells into osteoblasts and adipocytes. -other hsa-mir-382 Parkinson Disease 28260060 Bioinformatics analysis on the differentiation of bone mesenchymal stem cells into osteoblasts and adipocytes. -other hsa-mir-495 Parkinson Disease 28260060 Bioinformatics analysis on the differentiation of bone mesenchymal stem cells into osteoblasts and adipocytes. -other hsa-mir-543 Parkinson Disease 28260060 Bioinformatics analysis on the differentiation of bone mesenchymal stem cells into osteoblasts and adipocytes. -other hsa-mir-373 Breast Neoplasms 28260305 Effects of microRNA-373 on the proliferation and invasiveness of breast carcinoma and its mechanisms. -other hsa-mir-149 Chronic Obstructive Pulmonary Disease 28260877 Repression of Toll-like receptor-4 by microRNA-149-3p is associated with smoking-related COPD. -other hsa-mir-143 "Diabetes Mellitus, Type 2" 28270439 Comprehensive functional screening of miRNAs involved in fat cell insulin sensitivity among women. -other hsa-mir-652 "Diabetes Mellitus, Type 2" 28270439 Comprehensive functional screening of miRNAs involved in fat cell insulin sensitivity among women. -other hsa-mir-21 Diabetic Retinopathy 28270521 Pathogenic Role of microRNA-21 in Diabetic Retinopathy Through Downregulation of PPAR¦Á. -other hsa-mir-145 "Carcinoma, Colon" 28272349 The Influence of Spirulina platensis Filtrates on Caco-2 Proliferative Activity and Expression of Apoptosis-Related microRNAs and mRNA. -other hsa-mir-146 "Carcinoma, Colon" 28272349 The Influence of Spirulina platensis Filtrates on Caco-2 Proliferative Activity and Expression of Apoptosis-Related microRNAs and mRNA. -other hsa-mir-17 "Carcinoma, Colon" 28272349 The Influence of Spirulina platensis Filtrates on Caco-2 Proliferative Activity and Expression of Apoptosis-Related microRNAs and mRNA. -other hsa-mir-9 "Leukemia, Myeloid, Acute" 28272704 A minicircuitry comprised of microRNA-9 and SIRT1 contributes to leukemogenesis in t(8;21) acute myeloid leukemia. -other hsa-mir-34a Lung Fibrosis 28273432 p53 and miR-34a Feedback Promotes Lung Epithelial Injury and Pulmonary Fibrosis. -other hsa-mir-34a Hepatoblastoma 28277300 Exosomal miR-34s panel as potential novel diagnostic and prognostic biomarker in patients with hepatoblastoma. -other hsa-mir-34b Hepatoblastoma 28277300 Exosomal miR-34s panel as potential novel diagnostic and prognostic biomarker in patients with hepatoblastoma. -other hsa-mir-34c Hepatoblastoma 28277300 Exosomal miR-34s panel as potential novel diagnostic and prognostic biomarker in patients with hepatoblastoma. -other hsa-mir-27a Diabetic Nephropathy 28277542 MicroRNA-27a promotes podocyte injury via PPAR¦Ã-mediated ¦Â-catenin activation in diabetic nephropathy. -other hsa-mir-17 "Carcinoma, Pancreatic" 28280038 The NOP14/mutp53 axis suppressed p21 expression at both the transcriptional and posttranscriptional levels via induction of miR-17-5p in PDAC cells -other hsa-mir-194 Colorectal Carcinoma 28280361 MicroRNA-194 modulates epithelial-mesenchymal transition in human colorectal cancer metastasis. -other hsa-mir-489 "Carcinoma, Bladder" 28281959 miR-489 Suppresses Proliferation and Invasion of Human Bladder Cancer Cells. -other hsa-mir-183 "Squamous Cell Carcinoma, Tongue" 28281960 miR-183 Modulates Cell Apoptosis and Proliferation in Tongue Squamous Cell Carcinoma SCC25 Cell Line. -other hsa-mir-223 "Carcinoma, Lung" 28281961 MicroRNA-223 Promotes Tumor Progression in Lung Cancer A549 Cells via Activation of the NF-¦ÊB Signaling Pathway. -other hsa-mir-155 "Lymphoma, Large B-Cell, Diffuse" 28281962 MicroRNA-155 Downregulation Promotes Cell Cycle Arrest and Apoptosis in Diffuse Large B-Cell Lymphoma. -other hsa-mir-1284 "Carcinoma, Ovarian" 28281963 MicroRNA-1284 Inhibits Cell Viability and Induces Apoptosis of Ovarian Cancer Cell Line OVCAR3. -other hsa-mir-126 Influenza 28282445 Endothelial cell tropism is a determinant of H5N1 pathogenesis in mammalian species. -other hsa-mir-375 Prostate Neoplasms 28282880 Astaxanthin Inhibits PC-3 Xenograft Prostate Tumor Growth in Nude Mice. -other hsa-mir-487b Prostate Neoplasms 28282880 Astaxanthin Inhibits PC-3 Xenograft Prostate Tumor Growth in Nude Mice. -other hsa-mir-21 "Carcinoma, Lung" 28283413 Solasodine inhibits invasion of human lung cancer cell through downregulation of miR-21 and MMPs expression. -other hsa-mir-133a Heart Failure 28283551 A novel role for miR-133a in centrally mediated activation of the renin-angiotensin system in congestive heart failure. -other hsa-mir-122 Heart Diseases [unspecific] 28287427 The Role and Molecular Mechanism of Non-Coding RNAs in Pathological Cardiac Remodeling. -other hsa-mir-184 Heart Diseases [unspecific] 28287427 The Role and Molecular Mechanism of Non-Coding RNAs in Pathological Cardiac Remodeling. -other hsa-mir-34a Heart Diseases [unspecific] 28287427 The Role and Molecular Mechanism of Non-Coding RNAs in Pathological Cardiac Remodeling. -other hsa-mir-942 Preeclampsia 28287888 MiR-942 decreased before 20 weeks gestation in women with preeclampsia and was associated with the pathophysiology of preeclampsia in vitro. -other hsa-mir-106b Pituitary Adenoma 28288092 Effect of miR-106b on Invasiveness of Pituitary Adenoma via PTEN-PI3K/AKT. -other hsa-mir-200 "Colitis, Ulcerative" 28288169 The miR-200 family is increased in dysplastic lesions in ulcerative colitis patients. -other hsa-mir-15a "Diabetes Mellitus, Type 2" 28289072 Down-regulation of miR-15a/b accelerates fibrotic remodelling in the Type?2 diabetic human and mouse heart. -other hsa-mir-15b "Diabetes Mellitus, Type 2" 28289072 Down-regulation of miR-15a/b accelerates fibrotic remodelling in the Type?2 diabetic human and mouse heart. -other hsa-mir-223 Liver Injury 28295449 Hepatic mitochondrial DNA/Toll-like receptor 9/MicroRNA-223 forms a negative feedback loop to limit neutrophil overactivation and acetaminophen hepatotoxicity in mice. -other hsa-mir-122 Chronic Hepatitis C 28295463 "Immune phenotype and function of natural killer and T cells in chronic hepatitis C patients who received a single dose of anti-MicroRNA-122, RG-101." -other hsa-mir-33 Atherosclerosis 28296196 SIRT6 reduces macrophage foam cell formation by inducing autophagy and cholesterol efflux under ox-LDL condition. -other hsa-mir-7 Alzheimer Disease 28296235 the circular RNA circular RNA sponge for miR-7 (ciRS-7) has an important role in regulating BACE1 and APP protein levels -other hsa-mir-221 "Carcinoma, Thyroid, Papillary" 28297755 Expression of microRNA-221 and IL-17 in papillary thyroid carcinoma and correlation with clinicopathologic features. -other hsa-mir-146a "Adenocarcinoma, Lung" 28299977 Identification of lymph node metastasis-related microRNAs in lung adenocarcinoma and analysis of the underlying mechanisms using a bioinformatics approach. -other hsa-mir-150 "Adenocarcinoma, Lung" 28299977 Identification of lymph node metastasis-related microRNAs in lung adenocarcinoma and analysis of the underlying mechanisms using a bioinformatics approach. -other hsa-mir-342 "Adenocarcinoma, Lung" 28299977 Identification of lymph node metastasis-related microRNAs in lung adenocarcinoma and analysis of the underlying mechanisms using a bioinformatics approach. -other hsa-mir-375 "Carcinoma, Breast" 28300567 9-cis Retinoic acid modulates myotrophin expression and its miR in physiological and pathophysiological cell models. -other hsa-mir-18a "Carcinoma, Hepatocellular" 28302149 Identification and interaction analysis of key genes and microRNAs in hepatocellular carcinoma by bioinformatics analysis. -other hsa-mir-221 "Carcinoma, Hepatocellular" 28302149 Identification and interaction analysis of key genes and microRNAs in hepatocellular carcinoma by bioinformatics analysis. -other hsa-mir-21 Neoplasms [unspecific] 28302473 Quantitative relationship between chemical properties and bioactivities of anti-microRNA oligonucleotides targeted to tumor-associated microRNA-21. -other hsa-mir-4306 Neurodegenerative Diseases [unspecific] 28302480 Comprehensive investigation of aberrant microRNAs expression in cells culture model of MnCl2-induced neurodegenerative disease. -other hsa-mir-186 "Carcinoma, Colon" 28302487 TUG1 mediates methotrexate resistance in colorectal cancer via miR-186/CPEB2 axis. -other hsa-mir-205 "Carcinoma, Cervical" 28304186 miR-205 mediates the inhibition of cervical cancer cell proliferation using olmesartan. -other hsa-mir-21 Pancreatic Neoplasms 28304379 Development of bioluminescent chick chorioallantoic membrane (CAM) models for primary pancreatic cancer cells: a platform for drug testing. -other hsa-mir-7 "Squamous Cell Carcinoma, Esophageal" 28314263 Significance and Function of MicroRNA-7 in Oesophageal Squamous Cell Carcinoma. -other hsa-mir-21 "Squamous Cell Carcinoma, Oral" 28314265 Next-generation Sequencing for microRNA Profiling: MicroRNA-21-3p Promotes Oral Cancer Metastasis. -other hsa-mir-155 Lung Neoplasms 28315615 MIR155 Regulation of Ubiquilin1 and Ubiquilin2: Implications in Cellular Protection and Tumorigenesis. -other hsa-mir-135b Multiple Myeloma 28316065 Identification of key genes and construction of microRNA-mRNA regulatory networks in multiple myeloma by integrated multiple GEO datasets using bioinformatics analysis. -other hsa-mir-148a Multiple Myeloma 28316065 Identification of key genes and construction of microRNA-mRNA regulatory networks in multiple myeloma by integrated multiple GEO datasets using bioinformatics analysis. -other hsa-mir-181 Vascular Injuries 28316180 Effect and related mechanism of microRNA-181 attenuates oxidized low density lipoprotein induced vascular endothelial cell injury. -other hsa-mir-1 "Carcinoma, Prostate" 28317618 "MiR-1, a Potential Predictive Biomarker for Recurrence in Prostate Cancer After Radical Prostatectomy." -other hsa-mir-32 Cardiovascular Diseases [unspecific] 28319142 MicroRNA-32 promotes calcification in vascular smooth muscle cells: Implications as a novel marker for coronary artery calcification. -other hsa-mir-146a Infection [unspecific] 28319200 Induction of immunomodulatory miR-146a and miR-155 in small intestinal epithelium of Vibrio cholerae infected patients at acute stage of cholera. -other hsa-mir-155 Infection [unspecific] 28319200 Induction of immunomodulatory miR-146a and miR-155 in small intestinal epithelium of Vibrio cholerae infected patients at acute stage of cholera. -other hsa-mir-1 "Carcinoma, Prostate" 28320379 miRNAs associated with prostate cancer risk and progression. -other hsa-mir-145 "Carcinoma, Prostate" 28320379 miRNAs associated with prostate cancer risk and progression. -other hsa-mir-205 "Carcinoma, Prostate" 28320379 miRNAs associated with prostate cancer risk and progression. -other hsa-mir-21 "Carcinoma, Prostate" 28320379 miRNAs associated with prostate cancer risk and progression. -other hsa-mir-221 "Carcinoma, Prostate" 28320379 miRNAs associated with prostate cancer risk and progression. -other hsa-mir-375 "Carcinoma, Prostate" 28320379 miRNAs associated with prostate cancer risk and progression. -other hsa-mir-19b Wilms Tumor 28322459 "Effects of MicroRNA-19b on the Proliferation, Apoptosis, and Migration of Wilms' Tumor Cells Via the PTEN/PI3K/AKT Signaling Pathway." -other hsa-mir-133 "Cardiomyopathy, Hypertrophic" 28322824 MicroRNA-133 mediates cardiac diseases: Mechanisms and clinical implications. -other hsa-mir-608 Neuroinflammation 28326544 Personalized genetics of the cholinergic blockade of neuroinflammation. -other hsa-mir-29c Meningioma 28327132 Simultaneous analysis of miRNA-mRNA in human meningiomas by integrating transcriptome: A relationship between PTX3 and miR-29c. -other hsa-mir-30c Mitochondrial Metabolism Disease 28330939 Chlamydia preserves the mitochondrial network necessary for replication via microRNA-dependent inhibition of fission. -other hsa-mir-34a "Carcinoma, Breast" 28334277 "In bone metastasis miR-34a-5p absence inversely correlates with Met expression, while Met oncogene is unaffected by miR-34a-5p in non-metastatic and metastatic breast carcinomas." -other hsa-mir-200c "Carcinoma, Breast" 28334634 E3 Ubiquitin Ligase Cbl-b Prevents Tumor Metastasis by Maintaining the Epithelial Phenotype in Multiple Drug-Resistant Gastric and Breast Cancer Cells. -other hsa-mir-184 "Carcinoma, Breast" 28335433 Evaluation and Adaptation of a Laboratory-Based cDNA Library Preparation Protocol for Retrospective Sequencing of Archived MicroRNAs from up to 35-Year-Old Clinical FFPE Specimens. -other hsa-mir-221 "Carcinoma, Breast" 28335433 Evaluation and Adaptation of a Laboratory-Based cDNA Library Preparation Protocol for Retrospective Sequencing of Archived MicroRNAs from up to 35-Year-Old Clinical FFPE Specimens. -other hsa-mir-29a "Carcinoma, Breast" 28335433 Evaluation and Adaptation of a Laboratory-Based cDNA Library Preparation Protocol for Retrospective Sequencing of Archived MicroRNAs from up to 35-Year-Old Clinical FFPE Specimens. -other hsa-mir-363 "Carcinoma, Breast" 28335433 Evaluation and Adaptation of a Laboratory-Based cDNA Library Preparation Protocol for Retrospective Sequencing of Archived MicroRNAs from up to 35-Year-Old Clinical FFPE Specimens. -other hsa-mir-375 "Carcinoma, Breast" 28335433 Evaluation and Adaptation of a Laboratory-Based cDNA Library Preparation Protocol for Retrospective Sequencing of Archived MicroRNAs from up to 35-Year-Old Clinical FFPE Specimens. -other hsa-mir-455 "Carcinoma, Breast" 28335433 Evaluation and Adaptation of a Laboratory-Based cDNA Library Preparation Protocol for Retrospective Sequencing of Archived MicroRNAs from up to 35-Year-Old Clinical FFPE Specimens. -other hsa-mir-548p Atherosclerosis 28336556 Human MicroRNA-548p Decreases Hepatic Apolipoprotein B Secretion and Lipid Synthesis. -other hsa-mir-15a Breast Neoplasms 28337296 Tumor suppressor p53 induces miR-15a processing to inhibit neuronal apoptosis inhibitory protein (NAIP) in the apoptotic response DNA damage in breast cancer cell. -other hsa-mir-155 "Carcinoma, Breast" 28338193 Oncogenic miR-155 down-regulated upon activation of antitumor cytotoxic T lymphocytes by the fusion of dendritic cells with breast carcinoma cells. -other hsa-mir-576 "Carcinoma, Bladder" 28338199 MiR-576-3p is a novel marker correlated with poor clinical outcome in bladder cancer. -other hsa-mir-486 Osteosarcoma 28339053 miR-486 suppresses the development of osteosarcoma by regulating PKC-¦Ä pathway. -other hsa-mir-152 "Carcinoma, Hepatocellular" 28339081 HBx represses RIZ1 expression by DNA methyltransferase?1 involvement in decreased miR-152 in hepatocellular carcinoma. -other hsa-mir-126 Sjogren Syndrome 28339625 Cystatin S-a candidate biomarker for severity of submandibular gland involvement in Sj?gren's syndrome. -other hsa-mir-335 Sjogren Syndrome 28339625 Cystatin S-a candidate biomarker for severity of submandibular gland involvement in Sj?gren's syndrome. -other hsa-mir-122 Liver Injury 28341748 Drug-induced liver injury: recent advances in diagnosis and risk assessment. -other hsa-mir-124 Sepsis 28342874 Activation of PPAR¦Ã inhibits pro-inflammatory cytokines production by upregulation of miR-124 in?vitro and in?vivo. -other hsa-mir-503 Hepatitis C Virus Infection 28343379 Hepatitis C Virus Nonstructural 5A Protein (HCV-NS5A) Inhibits Hepatocyte Apoptosis through the NF-¦Êb/miR-503/bcl-2 Pathway. -other hsa-mir-551a "Carcinoma, Ovarian" 28345465 Demethoxycurcumin inhibited human epithelia ovarian cancer cells' growth via up-regulating miR-551a. -other hsa-mir-9 Breast Neoplasms 28345661 Stepwise analysis of MIR9 loci identifies miR-9-5p to be involved in Oestrogen regulated pathways in breast cancer patients. -other hsa-mir-21 Neoplasms [unspecific] 28346427 MiR-21 is required for anti-tumor immune response in mice: an implication for its bi-directional roles. -other hsa-mir-205 "Carcinoma, Breast" 28346474 The microRNA-205-5p is correlated to metastatic potential of 21T series: A breast cancer progression model. -other hsa-mir-145 "Carcinoma, Lung, Non-Small-Cell" 28347234 "Clinical value of miR-145-5p in NSCLC and potential molecular mechanism exploration: A retrospective study based on GEO, qRT-PCR, and TCGA data." -other hsa-mir-30 "Carcinoma, Breast" 28347244 The miR-30 family: Versatile players in breast cancer. -other hsa-mir-125b "Carcinoma, Bladder" 28347246 MicroRNA-125b predicts clinical outcome and suppressed tumor proliferation and migration in human gallbladder cancer. -other hsa-mir-186 Glioma 28351322 PVT1 affects growth of glioma microvascular endothelial cells by negatively regulating miR-186. -other hsa-mir-203 Liver Cirrhosis 28355233 Coding and non-coding gene regulatory networks underlie the immune response in liver cirrhosis. -other hsa-mir-219 Liver Cirrhosis 28355233 Coding and non-coding gene regulatory networks underlie the immune response in liver cirrhosis. -other hsa-mir-34a "Carcinoma, Hepatocellular" 28356025 Regulation of Apoptosis by SYB in HepG2 Liver Cancer Cells is Mediated by the P53/Caspase 9 Axis. -other hsa-mir-195 Colorectal Carcinoma 28356122 Integrated analysis identifies microRNA-195 as a suppressor of Hippo-YAP pathway in colorectal cancer. -other hsa-mir-149 "Squamous Cell Carcinoma, Tongue" 28356969 MicroRNA-149 targets specificity protein 1 to suppress human tongue squamous cell carcinoma cell proliferation and motility. -other hsa-mir-126 Multiple Sclerosis 28358058 MiR-126 and miR-126* regulate shear-resistant firm leukocyte adhesion to human brain endothelium. -other hsa-mir-92a Leukemia 28358188 Effective Integration of Targeted Tumor Imaging and Therapy Using Functionalized InP QDs with VEGFR2 Monoclonal Antibody and miR-92a Inhibitor. -other hsa-mir-608 Muscle Diseases [unspecific] 28358823 Genome-wide association screens for Achilles tendon and ACL tears and tendinopathy. -other hsa-mir-10b "Carcinoma, Renal Cell, Clear-Cell" 28360191 miR-10b is a prognostic marker in clear cell renal cell carcinoma. -other hsa-mir-155 Hypertension 28360962 Novel Immune Mechanisms in Hypertension and Cardiovascular Risk. -other hsa-mir-21 Hypertension 28360962 Novel Immune Mechanisms in Hypertension and Cardiovascular Risk. -other hsa-mir-1249 "Carcinoma, Hepatocellular" 28365245 Induced MiR-1249 expression by aberrant activation of Hedegehog signaling pathway in hepatocellular carcinoma. -other hsa-mir-181a Neuroblastoma 28365714 MicroRNA-181a Regulates Apoptosis and Autophagy Process in Parkinson's Disease by Inhibiting p38 Mitogen-Activated Protein Kinase (MAPK)/c-Jun N-Terminal Kinases (JNK) Signaling Pathways. -other hsa-mir-210 Atherosclerosis 28367268 Protection of Human Umbilical Vein Endothelial Cells against Oxidative Stress by MicroRNA-210. -other hsa-mir-21 Vascular Hypertrophy 28368454 Role and Regulation of MicroRNAs in Aldosterone-Mediated Cardiac Injury and Dysfunction in Male Rats. -other hsa-mir-200b Colitis 28370348 miR-200b-containing microvesicles attenuate experimental colitis associated intestinal fibrosis by inhibiting epithelial-mesenchymal transition. -other hsa-mir-451 Infection [unspecific] 28378118 miR-451 limits CD4+ T cell proliferative responses to infection in mice. -other hsa-mir-21 Asthma 28379062 Inhibition of MicroRNA-21 by an antagomir ameliorates allergic inflammation in a mouse model of asthma. -other hsa-mir-100 "Carcinoma, Gastric" 28381156 Characterization of exosomal RNAs derived from human gastric cancer cells by deep sequencing. -other hsa-mir-148a "Carcinoma, Gastric" 28381156 Characterization of exosomal RNAs derived from human gastric cancer cells by deep sequencing. -other hsa-mir-21 "Carcinoma, Gastric" 28381156 Characterization of exosomal RNAs derived from human gastric cancer cells by deep sequencing. -other hsa-mir-30a "Carcinoma, Gastric" 28381156 Characterization of exosomal RNAs derived from human gastric cancer cells by deep sequencing. -other hsa-let-7 "Carcinoma, Endometrial" 28381177 Dicer1 dysfunction promotes stemness and aggression in endometrial carcinoma. -other hsa-mir-125a Leukemia 28381182 Involvement of miR-125a in resistance to daunorubicin by inhibiting apoptosis in leukemia cell lines. -other hsa-mir-132 Fatty Liver [unspecific] 28381526 miRNA-132 induces hepatic steatosis and hyperlipidaemia by synergistic multitarget suppression. -other hsa-mir-16 Bronchopulmonary Dysplasia 28381639 Thus the intergenerational effects of gestational SS involve epigenetic regulation of HIF-1¦Á through specific miRs contributing to increased incidence of AA and BPD in the progenies -other hsa-mir-203 Pancreatic Neoplasms 28382422 The Role of Exosomes in Pancreatic Cancer Microenvironment. -other hsa-mir-21 Pancreatic Neoplasms 28382422 The Role of Exosomes in Pancreatic Cancer Microenvironment. -other hsa-mir-133a "Cardiomyopathy, Hypertrophic" 28382463 MicroRNAs Association in the Cardiac Hypertrophy Secondary to Complex Congenital Heart Disease in Children. -other hsa-mir-21 "Cardiomyopathy, Hypertrophic" 28382463 MicroRNAs Association in the Cardiac Hypertrophy Secondary to Complex Congenital Heart Disease in Children. -other hsa-mir-23b "Cardiomyopathy, Hypertrophic" 28382463 MicroRNAs Association in the Cardiac Hypertrophy Secondary to Complex Congenital Heart Disease in Children. -other hsa-mir-24 "Cardiomyopathy, Hypertrophic" 28382463 MicroRNAs Association in the Cardiac Hypertrophy Secondary to Complex Congenital Heart Disease in Children. -other hsa-mir-101 "Carcinoma, Prostate" 28384067 miR-101 Enhances Cisplatin-Induced DNA Damage Through Decreasing Nicotinamide Adenine Dinucleotide Phosphate Levels by Directly Repressing Tp53-Induced Glycolysis and Apoptosis Regulator Expression in Prostate Cancer Cells. -other hsa-let-7d Lung Fibrosis 28385811 Modified mesenchymal stem cells using miRNA transduction alter lung injury in a bleomycin model. -other hsa-mir-154 Lung Fibrosis 28385811 Modified mesenchymal stem cells using miRNA transduction alter lung injury in a bleomycin model. -other hsa-mir-122 Chronic Hepatitis C 28389707 The Race of 10 Synthetic RNAi-Based Drugs to the Pharmaceutical Market. -other hsa-mir-29c "Carcinoma, Colon" 28392396 p53 target miR-29c-3p suppresses colon cancer cell invasion and migration through inhibition of PHLDB2. -other hsa-mir-155 Influenza 28392443 Enhanced immunogenicity following miR-155 incorporation into the influenza A virus genome. -other hsa-mir-29b Infection [unspecific] 28394930 Analysis of host microRNA function uncovers a role for miR-29b-2-5p in Shigella capture by filopodia. -other hsa-mir-21 Graft-Versus-Host Disease 28396121 Antagonism of profibrotic microRNA-21 improves?outcome of murine chronic renal allograft dysfunction. -other hsa-mir-27b Ovarian Neoplasms 28396577 MicroRNA-27b functions as a new inhibitor of ovarian cancer-mediated vasculogenic mimicry through suppression of VE-cadherin expression. -other hsa-mir-200b Ovarian Neoplasms 28399108 Decreased levels of baseline and drug-induced tubulin polymerisation are hallmarks of resistance to taxanes in ovarian cancer cells and are associated with epithelial-to-mesenchymal transition. -other hsa-mir-200c Ovarian Neoplasms 28399108 Decreased levels of baseline and drug-induced tubulin polymerisation are hallmarks of resistance to taxanes in ovarian cancer cells and are associated with epithelial-to-mesenchymal transition. -other hsa-mir-155 "Carcinoma, Lung" 28400205 "Titanium dioxide aggregating nanoparticles induce autophagy and under-expression of microRNA 21 and 30a in A549 cell line: A comparative study with cobalt(II, III) oxide nanoparticles." -other hsa-mir-30a "Carcinoma, Lung" 28400205 "Titanium dioxide aggregating nanoparticles induce autophagy and under-expression of microRNA 21 and 30a in A549 cell line: A comparative study with cobalt(II, III) oxide nanoparticles." -other hsa-mir-10a "Lymphoma, Burkitt" 28400759 Human and Epstein-Barr Virus miRNA Profiling as Predictive Biomarkers for Endemic Burkitt Lymphoma. -other hsa-mir-21 Colorectal Carcinoma 28401648 Current Status and Perspectives Regarding LNA-Anti-miR Oligonucleotides and microRNA miR-21 Inhibitors as a Potential Therapeutic Option in Treatment of Colorectal Cancer. -other hsa-mir-210 "Carcinoma, Breast, Triple Negative" 28402752 The MicroRNA miR-210 Is Expressed by Cancer Cells but Also by the Tumor Microenvironment in Triple-Negative Breast Cancer. -other hsa-mir-155 Psoriasis 28402921 MiR-155 promotes cell proliferation and inhibits apoptosis by PTEN signaling pathway in the psoriasis. -other hsa-mir-29 "Diabetes Mellitus, Type 2" 28404597 Altered miR-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle. -other hsa-mir-155 Atherosclerosis 28407320 Role of TLR4 and miR-155 in peripheral blood mononuclear cell-mediated inflammatory reaction in coronary slow flow and coronary arteriosclerosis patients. -other hsa-mir-21 "Carcinoma, Gastric" 28407783 Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells. -other hsa-let-7e "Squamous Cell Carcinoma, Esophageal" 28408353 ZEB1 induced miR-99b/let-7e/miR-125a cluster promotes invasion and metastasis in esophageal squamous cell carcinoma. -other hsa-mir-125a "Squamous Cell Carcinoma, Esophageal" 28408353 ZEB1 induced miR-99b/let-7e/miR-125a cluster promotes invasion and metastasis in esophageal squamous cell carcinoma. -other hsa-mir-99b "Squamous Cell Carcinoma, Esophageal" 28408353 ZEB1 induced miR-99b/let-7e/miR-125a cluster promotes invasion and metastasis in esophageal squamous cell carcinoma. -other hsa-mir-122 Multiple Sclerosis 28411393 Global exosome transcriptome profiling reveals biomarkers for multiple sclerosis. -other hsa-mir-24 "Squamous Cell Carcinoma, Tongue" 28413152 Loss of PTEN Expression Is Associated With High MicroRNA 24 Level and Poor Prognosis in Patients With Tongue Squamous Cell Carcinoma. -other hsa-mir-21 Cardiovascular Diseases [unspecific] 28418864 Bone marrow-derived mesenchymal stem cells overexpressing MiR-21 efficiently repair myocardial damage in rats. -other hsa-mir-519b Osteoarthritis 28423042 Transforming growth factor ¦Â1 enhances heme oxygenase 1 expression in human synovial fibroblasts by inhibiting microRNA 519b synthesis. -other hsa-mir-155 Graft-Versus-Host Disease 28423578 Endothelial microparticles delivering microRNA-155 into T lymphocytes are involved in the initiation of acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation. -other hsa-mir-940 Ovarian Neoplasms 28423620 Exosomal miR-940 maintains SRC-mediated oncogenic activity in cancer cells: a possible role for exosomal disposal of tumor suppressor miRNAs. -other hsa-mir-143 Glaucoma 28424493 Regulation of intraocular pressure by microRNA cluster miR-143/145. -other hsa-mir-145 Glaucoma 28424493 Regulation of intraocular pressure by microRNA cluster miR-143/145. -other hsa-mir-21 Neoplasms [unspecific] 28427524 Kallistatin suppresses cancer development by multi-factorial actions. -other hsa-mir-33 Atherosclerosis 28428217 microRNA-33 Regulates Macrophage Autophagy in Atherosclerosis. -other hsa-mir-106b Glioma 28431179 miRNA Regulation in Gliomas: Usual Suspects in Glial Tumorigenesis and Evolving Clinical Applications. -other hsa-mir-21 Glioma 28431179 miRNA Regulation in Gliomas: Usual Suspects in Glial Tumorigenesis and Evolving Clinical Applications. -other hsa-mir-219 Glioma 28431179 miRNA Regulation in Gliomas: Usual Suspects in Glial Tumorigenesis and Evolving Clinical Applications. -other hsa-mir-26a Glioma 28431179 miRNA Regulation in Gliomas: Usual Suspects in Glial Tumorigenesis and Evolving Clinical Applications. -other hsa-mir-338 Glioma 28431179 miRNA Regulation in Gliomas: Usual Suspects in Glial Tumorigenesis and Evolving Clinical Applications. -other hsa-mir-203 Colon Neoplasms 28431272 Specific microRNA-mRNA Regulatory Network of Colon Cancer Invasion Mediated by Tissue Kallikrein-Related Peptidase 6. -other hsa-mir-155 "Leukemia, Myeloid, Acute" 28432220 miR-155 promotes FLT3-ITD-induced myeloproliferative disease through inhibition of the interferon response. -other hsa-mir-130b Diabetes Mellitus 28433632 inhibition of miR-130b-3p appears to improve mitochondrial biogenesis signaling and protect placental trophoblast cells from oxidative stress -other hsa-mir-93 "Carcinoma, Esophageal" 28434073 Direct Downregulation of B-Cell Translocation Gene 3 by microRNA-93 Is Required for Desensitizing Esophageal Cancer to Radiotherapy. -other hsa-mir-34a "Carcinoma, Rectal" 28435028 Antagonistic Effects of p53 and HIF1A on microRNA-34a Regulation of PPP1R11 and STAT3 and Hypoxia-induced Epithelial to Mesenchymal Transition in Colorectal Cancer Cells. -other hsa-mir-98 Atherosclerosis 28436142 Cortisol is associated with low frequency of interleukin 10-producing B cells in patients with atherosclerosis. -other hsa-mir-21 Sepsis 28437377 MicroRNA-21 Is Required for Local and Remote Ischemic Preconditioning in Multiple Organ Protection Against Sepsis. -other hsa-mir-214 Liver Diseases [unspecific] 28438567 A systematic evaluation of microRNAs in regulating human hepatic CYP2E1. -other hsa-mir-942 Liver Diseases [unspecific] 28438567 A systematic evaluation of microRNAs in regulating human hepatic CYP2E1. -other hsa-mir-21 Pancreatic Neoplasms 28438662 Never let it go: Stopping key mechanisms underlying metastasis to fight pancreatic cancer. -other hsa-mir-451 Glioblastoma 28440461 "The role of miR-451 in the switching between proliferation and migration in malignant glioma cells: AMPK signaling, mTOR modulation and Rac1 activation required." -other hsa-mir-122 Chronic Hepatitis C 28442604 Hepatitis C Virus Indirectly Disrupts DNA Damage-Induced p53 Responses by Activating Protein Kinase R. -other hsa-mir-140 Glioma 28443475 MicroRNA-140-5p inhibits cell proliferation and invasion by regulating VEGFA/MMP2 signaling in glioma. -other hsa-let-7 Neoplasms [unspecific] 28446596 Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1-3 family. -other hsa-mir-21 Cervical Neoplasms 28447761 miR-21 inhibitor suppresses cell proliferation and colony formation through regulating the PTEN/AKT pathway and improves paclitaxel sensitivity in cervical cancer cells. -other hsa-mir-7 "Carcinoma, Pancreatic" 28450156 microRNA-7 impairs autophagy-derived pools of glucose to suppress pancreatic cancer progression. -other hsa-mir-21 Brain Disease [unspecific] 28452880 Acute and subacute microRNA dysregulation is associated with cytokine responses in the rodent model of penetrating ballistic-like brain injury. -other hsa-mir-122 Chronic Hepatitis C 28456022 Cellular DEAD-box RNA helicase DDX6 modulates interaction of miR-122 with the 5' untranslated region of hepatitis C virus RNA. -other hsa-mir-372 "Carcinoma, Ovarian" 28456593 The role of miR-372 in ovarian carcinoma cell proliferation. -other hsa-mir-210 "Squamous Cell Carcinoma, Oral" 28459203 "Leptin acts on neoplastic behavior and expression levels of genes related to hypoxia, angiogenesis, and invasiveness in oral squamous cell carcinoma." -other hsa-mir-7 "Carcinoma, Hepatocellular" 28459371 Role of microRNA-7 and selenoprotein P in hepatocellular carcinoma. -other hsa-mir-7 Glioblastoma 28459998 Identification of miRNA-7 by genome-wide analysis as a critical sensitizer for TRAIL-induced apoptosis in glioblastoma cells. -other hsa-mir-30a Breast Neoplasms 28461244 miR-30a-5p suppresses breast tumor growth and metastasis through inhibition of LDHA-mediated Warburg effect. -other hsa-mir-21 Cardiovascular Diseases [unspecific] 28465657 The MicroRNA-21 signaling pathway is involved in prorenin receptor (PRR) -induced VEGF expression in ARPE-19 cells under a hyperglycemic condition. -other hsa-mir-21 Vascular Hypertrophy 28465975 "Review in Translational Cardiology: MicroRNAs and Myocardial Fibrosis in Aortic Valve Stenosis, a Deep Insight on Left Ventricular Remodeling." -other hsa-mir-146a "Carcinoma, Colon" 28466779 MicroRNA-146a induces immune suppression and drug-resistant colorectal cancer cells. -other hsa-mir-1 Preeclampsia 28466998 Cardiac remodelling and preeclampsia: an overview of overlapping miRNAs. -other hsa-mir-195 Preeclampsia 28466998 Cardiac remodelling and preeclampsia: an overview of overlapping miRNAs. -other hsa-mir-29b Preeclampsia 28466998 Cardiac remodelling and preeclampsia: an overview of overlapping miRNAs. -other hsa-mir-21 Prostate Neoplasms 28467474 Tonic suppression of PCAT29 by the IL-6 signaling pathway in prostate cancer: Reversal by resveratrol. -other hsa-mir-1180 "Carcinoma, Hepatocellular" 28468075 Bioinformatics on vascular invasion markers in hepatocellular carcinoma via Big-Data analysis. -other hsa-mir-149 "Carcinoma, Hepatocellular" 28468075 Bioinformatics on vascular invasion markers in hepatocellular carcinoma via Big-Data analysis. -other hsa-mir-744 "Carcinoma, Hepatocellular" 28468075 Bioinformatics on vascular invasion markers in hepatocellular carcinoma via Big-Data analysis. -other hsa-mir-940 "Carcinoma, Hepatocellular" 28468075 Bioinformatics on vascular invasion markers in hepatocellular carcinoma via Big-Data analysis. -other hsa-mir-155 Preeclampsia 28471953 "Association of microRNA-155, interleukin 17A, and proteinuria in preeclampsia." -other hsa-mir-29b Bronchopulmonary Dysplasia 28473324 miR-29b supplementation decreases expression of matrix proteins and improves alveolarization in mice exposed to maternal inflammation and neonatal hyperoxia. -other hsa-mir-204 Hypertension 28473439 Implication of Inflammation and Epigenetic Readers in Coronary Artery Remodeling in Patients With Pulmonary Arterial Hypertension. -other hsa-mir-223 Hypertension 28473439 Implication of Inflammation and Epigenetic Readers in Coronary Artery Remodeling in Patients With Pulmonary Arterial Hypertension. -other hsa-mir-122 Hepatitis C Virus Infection 28475652 Serum microRNA-122 and Wisteria floribunda agglutinin-positive Mac-2 binding protein are useful tools for liquid biopsy of the patients with hepatitis B virus and advanced liver fibrosis. -other hsa-mir-26a "Squamous Cell Carcinoma, Esophageal" 28476684 miR-26a and miR-26b inhibit esophageal squamous cancer cell proliferation through suppression of c-MYC pathway. -other hsa-mir-26b "Squamous Cell Carcinoma, Esophageal" 28476684 miR-26a and miR-26b inhibit esophageal squamous cancer cell proliferation through suppression of c-MYC pathway. -other hsa-mir-9 "Carcinoma, Gastric" 28476807 Expression of hsa-miR-9 and MYC Copy Number Variation in Hereditary Diffuse Gastric Cancer. -other hsa-mir-18a Retinoblastoma 28481041 Reduction of the tumorigenic potential of human retinoblastoma cell lines by TFF1 overexpression involves p53/caspase signaling and miR-18a regulation. -other hsa-let-7 Melanoma 28482074 The overexpression of Lin28B reduced mature let-7 microRNA expression in melanoma cell lines -other hsa-mir-181a "Carcinoma, Prostate" 28485104 MicroRNA-181a promotes docetaxel resistance in prostate cancer cells. -other hsa-mir-1 Gastric Neoplasms 28493075 MicroRNA-1 acts as a tumor suppressor microRNA by inhibiting angiogenesis-related growth factors in human gastric cancer. -other hsa-mir-122 Chronic Hepatitis C 28494029 Characterization of miR-122-independent propagation of HCV. -other hsa-let-7a Glioblastoma 28494471 Inhibition of neurotensin receptor 1 induces intrinsic apoptosis via let-7a-3p/Bcl-w axis in glioblastoma. -other hsa-mir-21 Peritoneal Dialysis Failure 28495592 miR-21 Promotes Fibrogenesis in Peritoneal Dialysis. -other hsa-mir-15a Chronic Hepatitis B 28498453 The inhibition of microRNA-15a suppresses hepatitis?B virus-associated liver cancer cell growth through the Smad/TGF-¦Â pathway. -other hsa-mir-125a "Carcinoma, Pancreatic" 28498896 "targeting the overexpression of PRDM14 suppresses cancer stem-like phenotypes, including liver metastasis, via miRNA regulation and siRNA-based therapy targeting it shows promise as a treatment for patients with pancreatic cancer" -other hsa-mir-24 Neoplasms [unspecific] 28500171 Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth. -other hsa-mir-200b Liver Cirrhosis 28502477 Knockdown of Hepatic Gonadotropin-Releasing Hormone by Vivo-Morpholino Decreases Liver Fibrosis in Multidrug Resistance Gene 2 Knockout Mice by Down-Regulation of miR-200b. -other hsa-mir-15a Breast Neoplasms 28509572 Effect of silibinin-loaded nano-niosomal coated with trimethyl chitosan on miRNAs expression in 2D and 3D models of T47D breast cancer cell line. -other hsa-mir-21 Breast Neoplasms 28509572 Effect of silibinin-loaded nano-niosomal coated with trimethyl chitosan on miRNAs expression in 2D and 3D models of T47D breast cancer cell line. -other hsa-mir-133a Coronary Artery Disease 28511772 Transcoronary Concentration Gradient of microRNA-133a and Outcome in Patients With Coronary Artery Disease. -other hsa-mir-34a Neoplasms [unspecific] 28511876 Chondroitin sulfate-functionalized polyamidoamine as a tumor-targeted carrier for miR-34a delivery. -other hsa-mir-34 "Adenocarcinoma, Lung" 28512015 The association between miR-34 dysregulation and distant metastases formation in lung adenocarcinoma. -other hsa-mir-10b Breast Ductal Carcinoma 28512126 Tumor-associated myoepithelial cells promote the invasive progression of ductal carcinoma in situ through activation of TGF¦Â signaling. -other hsa-mir-378 Melanoma 28513838 The emerging role of NPNT in tissue injury repair and bone homeostasis. -other hsa-mir-146a Rheumatoid Arthritis 28514293 The role of circulating miR-146a in patients with rheumatoid arthritis treated by Tripterygium wilfordii Hook F. -other hsa-mir-223 Sepsis 28515178 A model-specific role of microRNA-223 as a mediator of kidney injury during experimental sepsis. -other hsa-mir-125b "Carcinoma, Hepatocellular" 28521446 Candidate miRNAs and pathogenesis investigation for hepatocellular carcinoma based on bioinformatics analysis. -other hsa-mir-21 Polycythemia Vera 28522758 Decreased CAT results from hypoxia-induced miR-21 that downregulates CAT -other hsa-mir-133a Vascular Hypertrophy 28526870 these c-miRNAs may serve as markers for monitoring the RT responses -other hsa-mir-21 Vascular Hypertrophy 28526870 these c-miRNAs may serve as markers for monitoring the RT responses -other hsa-mir-199a "Carcinoma, Hepatocellular" 28529584 Anti-microRNA-21/221 and microRNA-199a transfected by ultrasound microbubbles induces the apoptosis of human hepatoma HepG2 cells. -other hsa-mir-21 "Carcinoma, Hepatocellular" 28529584 Anti-microRNA-21/221 and microRNA-199a transfected by ultrasound microbubbles induces the apoptosis of human hepatoma HepG2 cells. -other hsa-mir-221 "Carcinoma, Hepatocellular" 28529584 Anti-microRNA-21/221 and microRNA-199a transfected by ultrasound microbubbles induces the apoptosis of human hepatoma HepG2 cells. -other hsa-mir-375 "Adenocarcinoma, Lung" 28533502 miR-375 is essential for the progression of LUAD -other hsa-mir-92a "Carcinoma, Lung, Non-Small-Cell" 28534966 MicroRNA-92a promotes epithelial-mesenchymal transition through activation of PTEN/PI3K/AKT signaling pathway in non-small cell lung cancer metastasis. -other hsa-mir-129 Chondrosarcoma 28535514 MiR-129-5p Inhibits Proliferation and Invasion of Chondrosarcoma Cells by Regulating SOX4/Wnt/¦Â-Catenin Signaling Pathway. -other hsa-mir-145 "Adenocarcinoma, Lung" 28535533 MALAT1 Modulates TGF-¦Â1-Induced Endothelial-to-Mesenchymal Transition through Downregulation of miR-145. -other hsa-mir-33b Endometriosis 28537685 "MiR-33b can mediate cell apoptosis, alter VEGF and MMP-9 expression and affect proliferation and apoptosis of uterus endometrial cells, thus participating endometriosis formation" -other hsa-mir-126 Hemangioma 28538565 Urinary Excretion of MicroRNA-126 Is a Biomarker for Hemangioma Proliferation. -other hsa-mir-199a "Carcinoma, Colon" 28542779 Downregulation of miR-199a/b-5p is associated with GCNT2 induction upon epithelial-mesenchymal transition in colon cancer. -other hsa-mir-199b "Carcinoma, Colon" 28542779 Downregulation of miR-199a/b-5p is associated with GCNT2 induction upon epithelial-mesenchymal transition in colon cancer. -other hsa-mir-34a Bone Disease [unspecific] 28543623 Regulatory effect of microRNA-34a on osteogenesis and angiogenesis in glucocorticoid-induced osteonecrosis of the femoral head. -other hsa-mir-146a Arthritis 28545737 MicroRNA-146a governs fibroblast activation and joint pathology in arthritis. -other hsa-mir-146a Human Papilloma Virus Infection 28551628 Regulation of miRNA-146a and miRNA-150 Levels by Celecoxib in Premalignant Lesions of K14-HPV16 Mice. -other hsa-mir-150 Human Papilloma Virus Infection 28551628 Regulation of miRNA-146a and miRNA-150 Levels by Celecoxib in Premalignant Lesions of K14-HPV16 Mice. -other hsa-let-7a Spinal Cord Injuries 28552531 A causal relationship between the neurotherapeutic effects of miR182/7a and decreased expression of PRDM5. -other hsa-mir-182 Spinal Cord Injuries 28552531 A causal relationship between the neurotherapeutic effects of miR182/7a and decreased expression of PRDM5. -other hsa-mir-1 "Carcinoma, Colon" 28560697 The Cardiotoxic Mechanism of Doxorubicin (DOX) and Pegylated Liposomal DOX in Mice Bearing C-26 Colon Carcinoma: a Study Focused on microRNA Role for Toxicity Assessment of New Formulations. -other hsa-mir-21 "Carcinoma, Colon" 28560697 The Cardiotoxic Mechanism of Doxorubicin (DOX) and Pegylated Liposomal DOX in Mice Bearing C-26 Colon Carcinoma: a Study Focused on microRNA Role for Toxicity Assessment of New Formulations. -other hsa-mir-204 Hypertension 28565757 An exploratory study into the role of miR-204-5p in pregnancy-induced hypertension. -other hsa-mir-214 "Carcinoma, Gingival" 28565877 Elucidating the mechanism of miRNA-214 in the regulation of gingival carcinoma. -other hsa-mir-200c Colorectal Carcinoma 28567416 Negative Correlation between miR-200c and Decorin Plays an Important Role in the Pathogenesis of Colorectal Carcinoma. -other hsa-mir-7 "Carcinoma, Breast" 28571043 MicroRNA-7 suppresses the homing and migration potential of human endothelial cells to highly metastatic human breast cancer cells. -other hsa-mir-183 Neuropathic Pain 28572455 miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes. -other hsa-mir-375 "Carcinoma, Hepatocellular" 28577837 MiR-375 delivered by lipid-coated doxorubicin-calcium carbonate nanoparticles overcomes chemoresistance in hepatocellular carcinoma. -other hsa-mir-502 "Carcinoma, Prostate" 28578017 Functional polymorphism at the miR-502-binding site in the 3' untranslated region of the SETD8 gene increased the risk of prostate cancer in a sample of Iranian population. -other hsa-mir-21 Infection [unspecific] 28589100 MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection. -other hsa-mir-21 Human Cytomegalovirus Infection 28589873 Human cytomegalovirus microRNAs are carried by virions and dense bodies and are delivered to target cells. -other hsa-mir-218 Human Cytomegalovirus Infection 28589873 Human cytomegalovirus microRNAs are carried by virions and dense bodies and are delivered to target cells. -other hsa-mir-128 Glioblastoma 28591575 MicroRNA-Mediated Dynamic Bidirectional Shift between the Subclasses of Glioblastoma Stem-like Cells. -other hsa-mir-34a Acute Pancreatitis 28592850 NAD+ augmentation ameliorates acute pancreatitis through regulation of inflammasome signalling. -other hsa-mir-500 Human Immunodeficiency Virus Infection 28594894 "MicroRNAs upregulated during HIV infection target peroxisome biogenesis factors: Implications for virus biology, disease mechanisms and neuropathology." -other hsa-mir-93 Human Immunodeficiency Virus Infection 28594894 "MicroRNAs upregulated during HIV infection target peroxisome biogenesis factors: Implications for virus biology, disease mechanisms and neuropathology." -other hsa-mir-146a Psoriasis 28595995 miR-146b Probably Assists miRNA-146a in?the Suppression of Keratinocyte Proliferation and Inflammatory Responses?in Psoriasis. -other hsa-mir-146b Psoriasis 28595995 miR-146b Probably Assists miRNA-146a in?the Suppression of Keratinocyte Proliferation and Inflammatory Responses?in Psoriasis. -other hsa-mir-143 Preterm Labor 28596604 "miR-143 and miR-145 disrupt the cervical epithelial barrier through dysregulation of cell adhesion, apoptosis and proliferation." -other hsa-mir-145 Preterm Labor 28596604 "miR-143 and miR-145 disrupt the cervical epithelial barrier through dysregulation of cell adhesion, apoptosis and proliferation." -other hsa-mir-125b "Carcinoma, Renal Cell" 28599452 "miR-125b is associated with renal cell carcinoma cell migration, invasion and apoptosis." -other hsa-mir-21 Neuroblastoma 28599474 Reduction of miR-21 induces SK-N-SH cell apoptosis and inhibits proliferation via PTEN/PDCD4. -other hsa-mir-34a Ischemia-Reperfusion Injury 28599575 Suppression of miR-34a Expression in the Myocardium Protects Against Ischemia-Reperfusion Injury Through SIRT1 Protective Pathway. -other hsa-mir-494 Spinal Cord Injuries 28601045 MicroRNA-494 improves functional recovery and inhibits apoptosis by modulating PTEN/AKT/mTOR pathway in rats after spinal cord injury. -other hsa-mir-101 "Carcinoma, Ovarian" 28601063 "Clusters of microRNAs (miR-145, miR-31, miR-506, miR-101) most essential for metastasis of ovarian cancer including the families of microRNAs (miR-200, miR-214, miR-25) with dual role" -other hsa-mir-145 "Carcinoma, Ovarian" 28601063 "Clusters of microRNAs (miR-145, miR-31, miR-506, miR-101) most essential for metastasis of ovarian cancer including the families of microRNAs (miR-200, miR-214, miR-25) with dual role" -other hsa-mir-200 "Carcinoma, Ovarian" 28601063 "Clusters of microRNAs (miR-145, miR-31, miR-506, miR-101) most essential for metastasis of ovarian cancer including the families of microRNAs (miR-200, miR-214, miR-25) with dual role" -other hsa-mir-214 "Carcinoma, Ovarian" 28601063 "Clusters of microRNAs (miR-145, miR-31, miR-506, miR-101) most essential for metastasis of ovarian cancer including the families of microRNAs (miR-200, miR-214, miR-25) with dual role" -other hsa-mir-25 "Carcinoma, Ovarian" 28601063 "Clusters of microRNAs (miR-145, miR-31, miR-506, miR-101) most essential for metastasis of ovarian cancer including the families of microRNAs (miR-200, miR-214, miR-25) with dual role" -other hsa-mir-31 "Carcinoma, Ovarian" 28601063 "Clusters of microRNAs (miR-145, miR-31, miR-506, miR-101) most essential for metastasis of ovarian cancer including the families of microRNAs (miR-200, miR-214, miR-25) with dual role" -other hsa-mir-506 "Carcinoma, Ovarian" 28601063 "Clusters of microRNAs (miR-145, miR-31, miR-506, miR-101) most essential for metastasis of ovarian cancer including the families of microRNAs (miR-200, miR-214, miR-25) with dual role" -other hsa-mir-24 Liver Fibrosis 28602220 Inhibition of microRNA-24 increases liver fibrosis by enhanced menin expression in Mdr2-/- mice. -other hsa-mir-146a Amyotrophic Lateral Sclerosis 28612258 Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an?Early Stage. -other hsa-mir-155 Amyotrophic Lateral Sclerosis 28612258 Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an?Early Stage. -other hsa-mir-371a Testicular Germ Cell Tumor 28612337 microRNA-371a-3p as informative biomarker for the follow-up of testicular germ cell cancer patients. -other hsa-mir-125b Melanoma 28614272 Quantification of microRNA-21 and microRNA-125b in melanoma tissue. -other hsa-mir-205 Melanoma 28614272 Quantification of microRNA-21 and microRNA-125b in melanoma tissue. -other hsa-mir-182 Autism Spectrum Disorder 28617945 microRNA cluster 106a~363 is involved in T helper 17 cell differentiation. -other hsa-mir-212 Autism Spectrum Disorder 28617945 microRNA cluster 106a~363 is involved in T helper 17 cell differentiation. -other hsa-mir-363 Autism Spectrum Disorder 28617945 microRNA cluster 106a~363 is involved in T helper 17 cell differentiation. -other hsa-mir-124 Stroke 28624203 Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia. -other hsa-mir-494 Ischemic Diseases [unspecific] 28624225 Inhibition of Mef2a Enhances Neovascularization via Post-transcriptional Regulation of 14q32 MicroRNAs miR-329 and miR-494. -other hsa-mir-21 Breast Neoplasms 28628833 Urtica dioica extract suppresses miR-21 and metastasis-related genes in breast cancer. -other hsa-mir-451 Glioblastoma 28629521 Erythropoietin Promotes Glioblastoma via miR-451 Suppression. -other hsa-mir-200a Esophageal Neoplasms 28635228 MALAT1 functions as a competing endogenous RNA to regulate the expressions of ZEB1 and ZEB2 by sponging miR-200a and promotes invasion and migration of esophageal cancer cells through inducing epithelial-mesenchymal transition -other hsa-mir-34a Osteosarcoma 28635396 MicroRNA-34a inhibits tumor invasion and metastasis in osteosarcoma partly by effecting C-IAP2 and Bcl-2. -other hsa-mir-146a Muscular Dystrophy 28637335 Astrocyte-produced miR-146a as a mediator of motor neuron loss in spinal muscular atrophy. -other hsa-mir-146a Atherosclerosis 28637783 Paradoxical Suppression of Atherosclerosis in the Absence of microRNA-146a. -other hsa-mir-155 Ischemia-Reperfusion Injury 28640790 MicroRNA-155 Deficiency in Kupffer Cells Ameliorates Liver Ischemia-Reperfusion Injury in Mice. -other hsa-mir-145 Prostate Neoplasms 28641312 Impact of novel miR-145-3p regulatory networks on survival in patients with castration-resistant prostate cancer. -other hsa-mir-155 Human Cytomegalovirus Infection 28642130 mir-155 expression is downregulated in kidney transplant patients with human cytomegalovirus infection. -other hsa-mir-122 "Carcinoma, Hepatocellular" 28642869 Detection of MicroRNA in Hepatic Cirrhosis and Hepatocellular Carcinoma in Hepatitis C Genotype-4 in Egyptian Patients. -other hsa-mir-122 Chronic Hepatitis C 28642978 Ectopic delivery of miR-200c diminishes hepatitis C virus infectivity through transcriptional and translational repression of Occludin. -other hsa-mir-140 Gout 28647469 Intra-articular injection of microRNA-140 (miRNA-140) alleviates osteoarthritis (OA) progression by modulating extracellular matrix (ECM) homeostasis in rats. -other hsa-mir-30d "Carcinoma, Colon" 28651493 Mir-30d suppresses cell proliferation of colon cancer cells by inhibiting cell autophagy and promoting cell apoptosis. -other hsa-mir-34a Alzheimer Disease 28652929 TNF-¦Á and Beyond: Rapid Mitochondrial Dysfunction Mediates TNF-¦Á-Induced Neurotoxicity. -other hsa-mir-125b "Carcinoma, Hepatocellular" 28654261 Astragalin Reduces Hexokinase 2 through Increasing miR-125b to Inhibit the Proliferation of Hepatocellular Carcinoma Cells in Vitro and in Vivo. -other hsa-mir-96 "Carcinoma, Lung, Non-Small-Cell" 28656287 "Identification and characterization of miR-96, a potential biomarker of NSCLC, through bioinformatic analysis." -other hsa-mir-34a Neoplasms [unspecific] 28657476 Comparison of Peptide- and Lipid-Based Delivery of miR-34a-5p Mimic into PPC-1 Cells. -other hsa-mir-23a Vascular Disease [unspecific] 28662151 Bone marrow mesenchymal stem cell-derived vascular endothelial growth factor attenuates cardiac apoptosis via regulation of cardiac miRNA-23a and miRNA-92a in a rat model of myocardial infarction. -other hsa-mir-92a Vascular Disease [unspecific] 28662151 Bone marrow mesenchymal stem cell-derived vascular endothelial growth factor attenuates cardiac apoptosis via regulation of cardiac miRNA-23a and miRNA-92a in a rat model of myocardial infarction. -other hsa-mir-155 Systemic Lupus Erythematosus 28665018 "MiR-155*, miR-34b and miR-34a levels in T lymphocytes and corresponding MVs were deregulated in SLE when compared to healthy individuals" -other hsa-mir-34a Systemic Lupus Erythematosus 28665018 "MiR-155*, miR-34b and miR-34a levels in T lymphocytes and corresponding MVs were deregulated in SLE when compared to healthy individuals" -other hsa-mir-34b Systemic Lupus Erythematosus 28665018 "MiR-155*, miR-34b and miR-34a levels in T lymphocytes and corresponding MVs were deregulated in SLE when compared to healthy individuals" -other hsa-mir-155 "Carcinoma, Hepatocellular" 28670383 "MiR-155 up-regulated by TGF-¦Â promotes epithelial-mesenchymal transition, invasion and metastasis of human hepatocellular carcinoma cells in vitro." -other hsa-mir-16 Neoplasms [unspecific] 28670496 Resistance to cancer chemotherapeutic drugs is determined by pivotal microRNA regulators. -other hsa-mir-1 Sepsis 28673002 IGF-1 may predict the severity and outcome of patients with sepsis and be associated with microRNA-1 level changes. -other hsa-mir-21 Atherosclerosis 28674080 "Macrophage deficiency of miR-21 promotes apoptosis, plaque necrosis, and vascular inflammation during atherogenesis." -other hsa-mir-200c Lung Neoplasms 28675952 A novel fine tuning scheme of miR-200c in modulating lung cell redox homeostasis. -other hsa-let-7b Glioblastoma 28677425 IKBKE promotes glioblastoma progression by establishing the regulatory feedback loop of IKBKE/YAP1/miR-Let-7b/i. -other hsa-mir-200a "Squamous Cell Carcinoma, Head and Neck" 28677748 Salivary miR-93 and miR-200a as post-radiotherapy biomarkers in head and neck squamous cell carcinoma. -other hsa-mir-93 "Squamous Cell Carcinoma, Head and Neck" 28677748 Salivary miR-93 and miR-200a as post-radiotherapy biomarkers in head and neck squamous cell carcinoma. -other hsa-mir-126 Atherosclerosis 28678312 Identification of miRNAs as atherosclerosis biomarkers and functional role of miR-126 in atherosclerosis progression through MAPK signalling pathway. -other hsa-mir-122a "Carcinoma, Hepatocellular" 28686599 Flux balance analysis predicts Warburg-like effects of mouse hepatocyte deficient in miR-122a. -other hsa-mir-29a Bladder Neoplasms 28687357 Circular RNA MYLK as a competing endogenous RNA promotes bladder cancer progression through modulating VEGFA/VEGFR2 signaling pathway. -other hsa-let-7a "Carcinoma, Hepatocellular" 28691642 XIAP 3'-untranslated region serves as a competitor for HMGA2 by arresting endogenous let-7a-5p in human hepatocellular carcinoma. -other hsa-mir-125b "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 28693195 MicroRNA-125b targeted STAT3 to inhibit laryngeal squamous cell carcinoma cell growth and motility. -other hsa-mir-92b Ovarian Neoplasms 28693226 Screening of potentially crucial genes and regulatory factors involved in epithelial ovarian cancer using microarray analysis. -other hsa-mir-92b Colorectal Carcinoma 28693229 MicroRNAs as outcome predictors in patients with metastatic colorectal cancer treated with bevacizumab in combination with FOLFOX. -other hsa-mir-106a Colorectal Carcinoma 28693239 Biological effects and clinical characteristics of microRNA-106a in human colorectal cancer -other hsa-mir-296 Nasal Cavity Inverting Papilloma 28693263 Role of microRNA-296-3p in the malignant transformation of sinonasal inverted papilloma. -other hsa-mir-210 Prostate Neoplasms 28693582 Oncogenic miR-210-3p promotes prostate cancer cell EMT and bone metastasis via NF-¦ÊB signaling pathway. -other hsa-mir-24 Blood Coagulation Disorders 28694557 Overexpression of miR-24 Is Involved in the Formation of Hypocoagulation State after Severe Trauma by Inhibiting the Synthesis of Coagulation Factor X. -other hsa-mir-92a Cardiovascular Diseases [unspecific] 28696247 MicroRNA-92a Mediates Endothelial Dysfunction in CKD. -other hsa-mir-548f Leukemia 28698179 A Novel Regulatory Mechanism of Smooth Muscle ¦Á-Actin Expression by NRG-1/circACTA2/miR-548f-5p Axis. -other hsa-mir-27b "Diabetes Mellitus, Type 2" 28698281 MiR-27b augments bone marrow progenitor cell survival via suppressing the mitochondrial apoptotic pathway in Type 2 diabetes. -other hsa-mir-21 Myocardial Infarction 28699517 Circadian MicroRNAs in Cardioprotection. -other hsa-mir-29a Breast Neoplasms 28701793 The miR-29 transcriptome in endocrine-sensitive and resistant breast cancer cells. -other hsa-mir-21 "Carcinoma, Lung" 28705115 MicroRNA-21 versus microRNA-34: Lung cancer promoting and inhibitory microRNAs analysed in silico and in vitro and their clinical impact. -other hsa-mir-34 "Carcinoma, Lung" 28705115 MicroRNA-21 versus microRNA-34: Lung cancer promoting and inhibitory microRNAs analysed in silico and in vitro and their clinical impact. -other hsa-mir-21 Vascular Disease [unspecific] 28707876 Fluorescence Light-Up Biosensor for MicroRNA Based on the Distance-Dependent Photoinduced Electron Transfer. -other hsa-mir-34a Ischemia-Reperfusion Injury 28709867 Attenuation of the hypoxia-induced miR-34a protects cardiomyocytes through maintenance of glucose metabolism. -other hsa-mir-375 Oral Neoplasms 28713923 The differential regulation of microRNAs is associated with oral cancer -other hsa-mir-204 Ischemia-Reperfusion Injury 28714326 "miR-204 inhibitor upregulated the activity and expression of RAP2C, while miR-204 mimic played the opposite role" -other hsa-mir-21 "Carcinoma, Renal Cell" 28714373 Targeting miR-21 decreases expression of multi-drug resistant genes and promotes chemosensitivity of renal carcinoma. -other hsa-mir-424 Early-Stage Colon Adenocarcinoma 28714374 Screening key genes and miRNAs in early-stage colon adenocarcinoma by RNA-sequencing. -other hsa-mir-548am Early-Stage Colon Adenocarcinoma 28714374 Screening key genes and miRNAs in early-stage colon adenocarcinoma by RNA-sequencing. -other hsa-mir-548c Early-Stage Colon Adenocarcinoma 28714374 Screening key genes and miRNAs in early-stage colon adenocarcinoma by RNA-sequencing. -other hsa-mir-548i Early-Stage Colon Adenocarcinoma 28714374 Screening key genes and miRNAs in early-stage colon adenocarcinoma by RNA-sequencing. -other hsa-mir-661 "Carcinoma, Lung, Non-Small-Cell" 28716024 MiR-661 promotes tumor invasion and metastasis by directly inhibiting RB1 in non small cell lung cancer -other hsa-mir-613 Glioblastoma 28718378 MicroRNA-613 is downregulated in HCMV-positive glioblastoma and inhibits tumour progression by targeting arginase-2. -other hsa-mir-29b Myocardial Infarction 28722488 Berberine promotes ischemia-induced angiogenesis in mice heart via upregulation of microRNA-29b. -other hsa-mir-155 Glioma 28724215 Melatonin inhibits proliferation and invasion via repression of miRNA-155 in glioma cells. -other hsa-mir-21 Glioblastoma 28727188 we highlighted utilization of miR-21 as diagnostic and therapeutic biomarker for GBM patients -other hsa-mir-30a "Carcinoma, Hepatocellular" 28732393 MicroRNA-30a suppresses tumor progression by blocking Ras/Raf/MEK/ERK signaling pathway in hepatocellular carcinoma -other hsa-mir-18a Endomyocardial Fibrosis 28733035 MiR-18a-5p inhibits endothelial-mesenchymal transition and cardiac fibrosis through the Notch2 pathway. -other hsa-let-7 Neuroinflammation 28737113 "Key pro-inflammatory ( miR-155, miR-27b, miR-326), anti-inflammatory ( miR-124, miR-146a, miR-21, miR-223), and mixed immunomodulatory ( let-7 family) miRNAs regulate neuroinflammation in various pathologies" -other hsa-mir-124 Neuroinflammation 28737113 "Key pro-inflammatory ( miR-155, miR-27b, miR-326), anti-inflammatory ( miR-124, miR-146a, miR-21, miR-223), and mixed immunomodulatory ( let-7 family) miRNAs regulate neuroinflammation in various pathologies" -other hsa-mir-146a Neuroinflammation 28737113 "Key pro-inflammatory ( miR-155, miR-27b, miR-326), anti-inflammatory ( miR-124, miR-146a, miR-21, miR-223), and mixed immunomodulatory ( let-7 family) miRNAs regulate neuroinflammation in various pathologies" -other hsa-mir-155 Neuroinflammation 28737113 "Key pro-inflammatory ( miR-155, miR-27b, miR-326), anti-inflammatory ( miR-124, miR-146a, miR-21, miR-223), and mixed immunomodulatory ( let-7 family) miRNAs regulate neuroinflammation in various pathologies" -other hsa-mir-21 Neuroinflammation 28737113 "Key pro-inflammatory ( miR-155, miR-27b, miR-326), anti-inflammatory ( miR-124, miR-146a, miR-21, miR-223), and mixed immunomodulatory ( let-7 family) miRNAs regulate neuroinflammation in various pathologies" -other hsa-mir-223 Neuroinflammation 28737113 "Key pro-inflammatory ( miR-155, miR-27b, miR-326), anti-inflammatory ( miR-124, miR-146a, miR-21, miR-223), and mixed immunomodulatory ( let-7 family) miRNAs regulate neuroinflammation in various pathologies" -other hsa-mir-27b Neuroinflammation 28737113 "Key pro-inflammatory ( miR-155, miR-27b, miR-326), anti-inflammatory ( miR-124, miR-146a, miR-21, miR-223), and mixed immunomodulatory ( let-7 family) miRNAs regulate neuroinflammation in various pathologies" -other hsa-mir-326 Neuroinflammation 28737113 "Key pro-inflammatory ( miR-155, miR-27b, miR-326), anti-inflammatory ( miR-124, miR-146a, miR-21, miR-223), and mixed immunomodulatory ( let-7 family) miRNAs regulate neuroinflammation in various pathologies" -other hsa-mir-141 "Carcinoma, Colon" 28739727 miR-141 Inhibits Proliferation and Migration of Colorectal Cancer SW480 Cells. -other hsa-mir-96 "Adenocarcinoma, Colon" 28742206 Bioinformatics analysis of RNA-seq data revealed critical genes in colon adenocarcinoma -other hsa-mir-200c Colorectal Carcinoma 28745318 Core 3 mucin-type O-glycan restoration in colorectal cancer cells promotes MUC1/p53/miR-200c-dependent epithelial identity. -other hsa-mir-34a Hearing Loss 28756190 miR-34a/Bcl-2 signaling pathway contributes to age-related hearing loss by modulating hair cell apoptosis. -other hsa-mir-30a Medulloblastoma 28757413 "Restoration of miR-30a expression inhibits growth, tumorigenicity of medulloblastoma cells accompanied by autophagy inhibition." -other hsa-mir-34a Melanoma 28759238 Ternary Nanoparticles with a Sheddable Shell Efficiently Deliver MicroRNA-34a against CD44-Positive Melanoma. -other hsa-mir-375 "Carcinoma, Hepatocellular" 28769563 Delivery of miR-375 and doxorubicin hydrochloride by lipid-coated hollow mesoporous silica nanoparticles to overcome multiple drug resistance in hepatocellular carcinoma -other hsa-mir-16 "Carcinoma, Hepatocellular" 28770611 Clinical significance of miRNA-autophagy transcript expression in patients with hepatocellular carcinoma -other hsa-mir-221 Bladder Neoplasms 28770966 Inhibition of miR-221 influences bladder cancer cell proliferation and apoptosis. -other hsa-mir-146a Ischemia-Reperfusion Injury 28771774 MiR-146a protects small intestine against ischemia/reperfusion injury by down-regulating TLR4/TRAF6/NF-¦ÊB pathway. -other hsa-mir-1274a Neoplasms [unspecific] 28774834 "the present review discussed the role of FoxOs in association with miRNAs such as miR-182, miR-135b, miR-499-5p, miR-1274a, miR-150, miR-34b/c and miR-625" -other hsa-mir-135b Neoplasms [unspecific] 28774834 "the present review discussed the role of FoxOs in association with miRNAs such as miR-182, miR-135b, miR-499-5p, miR-1274a, miR-150, miR-34b/c and miR-623" -other hsa-mir-150 Neoplasms [unspecific] 28774834 "the present review discussed the role of FoxOs in association with miRNAs such as miR-182, miR-135b, miR-499-5p, miR-1274a, miR-150, miR-34b/c and miR-626" -other hsa-mir-182 Neoplasms [unspecific] 28774834 "the present review discussed the role of FoxOs in association with miRNAs such as miR-182, miR-135b, miR-499-5p, miR-1274a, miR-150, miR-34b/c and miR-622" -other hsa-mir-34b Neoplasms [unspecific] 28774834 "the present review discussed the role of FoxOs in association with miRNAs such as miR-182, miR-135b, miR-499-5p, miR-1274a, miR-150, miR-34b/c and miR-627" -other hsa-mir-34c Neoplasms [unspecific] 28774834 "the present review discussed the role of FoxOs in association with miRNAs such as miR-182, miR-135b, miR-499-5p, miR-1274a, miR-150, miR-34b/c and miR-628" -other hsa-mir-499 Neoplasms [unspecific] 28774834 "the present review discussed the role of FoxOs in association with miRNAs such as miR-182, miR-135b, miR-499-5p, miR-1274a, miR-150, miR-34b/c and miR-624" -other hsa-mir-622 Neoplasms [unspecific] 28774834 "the present review discussed the role of FoxOs in association with miRNAs such as miR-182, miR-135b, miR-499-5p, miR-1274a, miR-150, miR-34b/c and miR-629" -other hsa-mir-155 "Leukemia, Lymphocytic, Chronic, B-Cell" 28783166 Anti-leukemic activity of microRNA-26a in a chronic lymphocytic leukemia mouse model. -other hsa-mir-26a "Leukemia, Lymphocytic, Chronic, B-Cell" 28783166 Anti-leukemic activity of microRNA-26a in a chronic lymphocytic leukemia mouse model. -other hsa-mir-33b Asthma 28785038 Inhibition of airway inflammation in a cockroach allergen model of asthma by agonists of miRNA-33b. -other hsa-mir-20a Ovarian Neoplasms 28789409 MicroRNA-20a contributes to cisplatin-resistance and migration of OVCAR3 ovarian cancer cell line. -other hsa-mir-29c Lung Fibrosis 28799781 MicroRNA-29c Prevents Pulmonary Fibrosis by Regulating Epithelial Cell Renewal and Apoptosis. -other hsa-mir-223 Traumatic Brain Injury 28804446 Induction of miR-155 after Brain Injury Promotes Type 1 Interferon and has a Neuroprotective Effect. -other hsa-let-7a Multiple Myeloma 28808676 "a thymidine-kinase-deleted let-7a-regulated vaccinia virus was safe and effective for mice, warranting clinical trials in humans" -other hsa-mir-1275 "Carcinoma, Hepatocellular" 28817968 Destabilizing the interplay between miR-1275 and IGF2BPs by Tamarix articulata and quercetin in hepatocellular carcinoma. -other hsa-mir-18a Pancreatic Neoplasms 28822990 ¦ÁM and ¦ÃM can induce apoptosis and autophagy in pancreatic cancer cells and that their anti-cancer effect is likely to be associated with miR-18a -other hsa-mir-222 "Leukemia, Lymphocytic, Chronic, B-Cell" 28824233 Inhibition of MicroRNA miR-222 with LNA Inhibitor Can Reduce Cell Proliferation in B Chronic Lymphoblastic Leukemia -other hsa-mir-155 Neuronal Apoptosis-Related Diseases 28831740 "Expression of miR-155 associated with Toll-like receptors 3, 7, and 9 transcription in the olfactory bulbs of cattle naturally infected with BHV5." -other hsa-mir-145 Prostate Neoplasms 28843521 Curcumin suppresses proliferation and in vitro invasion of human prostate cancer stem cells by ceRNA effect of miR-145 and lncRNA-ROR. -other hsa-mir-122 Chronic Hepatitis C 28844749 Immune responses in DAA treated chronic hepatitis C patients with and without prior RG-101 dosing. -other hsa-mir-195 "Carcinoma, Lung, Non-Small-Cell" 28848163 Knockdown of Lncrna PVT1 Enhances Radiosensitivity in Non-Small Cell Lung Cancer by Sponging Mir-195. -other hsa-mir-140 Autism Spectrum Disorder 28848387 "Expression and Regulatory Network Analysis of miR-140-3p, a New Potential Serum Biomarker for Autism Spectrum Disorder." -other hsa-mir-205 Heart Failure 28849082 Short?term vagus nerve stimulation reduces myocardial apoptosis by downregulating microRNA?205 in rats with chronic heart failure. -other hsa-mir-146a Graft-Versus-Host Disease 28853768 Systemic Treatment with a miR-146a Mimic Suppresses Endotoxin Sensitivity and Partially Protects Mice from the Progression of Acute Graft-versus-Host Disease. -other hsa-mir-30a Stroke 28854438 Down-Regulation of Lncrna MALAT1 Attenuates Neuronal Cell Death Through Suppressing Beclin1-Dependent Autophagy by Regulating Mir-30a in Cerebral Ischemic Stroke. -other hsa-mir-222 Melanoma 28858076 KIT and mir-222 might be key genomic contributors toward the clinical differences observed -other hsa-mir-214 Sepsis 28858140 miRNA-214 Protects Sepsis-Induced Myocardial Injury. -other hsa-mir-223 Chronic Hepatitis C 28864162 "Treatment-Induced Viral Cure of Hepatitis C Virus-Infected Patients Involves a Dynamic Interplay among three Important Molecular Players in Lipid Homeostasis: Circulating microRNA (miR)-24, miR-223, and Proprotein Convertase Subtilisin/Kexin Type 9." -other hsa-mir-24 Chronic Hepatitis C 28864162 "Treatment-Induced Viral Cure of Hepatitis C Virus-Infected Patients Involves a Dynamic Interplay among three Important Molecular Players in Lipid Homeostasis: Circulating microRNA (miR)-24, miR-223, and Proprotein Convertase Subtilisin/Kexin Type 9." -other hsa-mir-31 Myocardial Infarction 28865712 MicroRNA-31 promotes adverse cardiac remodeling and dysfunction in ischemic heart disease. -other hsa-mir-29b Lung Neoplasms 28869603 "DNMT1 and KIT form a positive regulatory loop, in which ectopic DNMT1 expression increases, whereas targeted DNMT1 depletion abrogates KIT signaling cascade through Sp1/miR-29b network" -other hsa-mir-143 Infection [unspecific] 28870451 MicroRNA-based transcriptomic responses of Atlantic salmon during infection by the intracellular bacterium Piscirickettsia salmonis. -other hsa-mir-181 Infection [unspecific] 28870451 MicroRNA-based transcriptomic responses of Atlantic salmon during infection by the intracellular bacterium Piscirickettsia salmonis. -other hsa-mir-21 Infection [unspecific] 28870451 MicroRNA-based transcriptomic responses of Atlantic salmon during infection by the intracellular bacterium Piscirickettsia salmonis. -other hsa-mir-194 Rectum Adenocarcinoma 28870889 miR-194 as predictive biomarker of responsiveness to neoadjuvant chemoradiotherapy in patients with locally advanced rectal adenocarcinoma. -other hsa-mir-449a Colon Neoplasms 28878284 MicroRNA-449a deficiency promotes colon carcinogenesis. -other hsa-mir-494 Ischemic Diseases [unspecific] 28880896 Extract of Spatholobus suberctus Dunn ameliorates ischemia-induced injury by targeting miR-494. -other hsa-mir-200b Retinal Vascular Disease 28882646 Protective effect of miR-200b/c by inhibiting vasohibin-2 in human retinal microvascular endothelial cells. -other hsa-mir-200c Retinal Vascular Disease 28882646 Protective effect of miR-200b/c by inhibiting vasohibin-2 in human retinal microvascular endothelial cells. -other hsa-mir-146a Atherosclerosis 28882869 "EV-derived miRNAs from atherogenic macrophages, in particular miR-146a, may accelerate the development of atherosclerosis by decreasing cell migration and promoting macrophage entrapment in the vessel wall" -other hsa-mir-193b Liposarcoma 28882999 miR-193b-Regulated Signaling Networks Serve as Tumor Suppressors in Liposarcoma and Promote Adipogenesis in Adipose-Derived Stem Cells. -other hsa-mir-29 Alveolar Rhabdomyosarcoma 28883017 "the NF¦ÊB-YY1-miR-29 regulatory circuit is dysregulated, resulting in repression of miR-29 and loss of the associated tumor suppressor activity" -other hsa-mir-15a Heart Valve Disease 28888871 Interplay of mitochondria apoptosis regulatory factors and microRNAs in valvular heart disease. -other hsa-mir-29a Heart Valve Disease 28888871 Interplay of mitochondria apoptosis regulatory factors and microRNAs in valvular heart disease. -other hsa-mir-1 Myocardial Infarction 28894747 "regulatory effects on miR-1, miR-133, Cx43, and Cx45 might be a possible mechanism of WXKL in the treatment of MI at the gene level" -other hsa-mir-133 Myocardial Infarction 28894747 "regulatory effects on miR-1, miR-133, Cx43, and Cx45 might be a possible mechanism of WXKL in the treatment of MI at the gene level" -other hsa-mir-200b Colorectal Carcinoma 28899657 HIF-1¦Á/Ascl2/miR-200b regulatory feedback circuit modulated the epithelial-mesenchymal transition (EMT) in colorectal cancer cells. -other hsa-mir-17 Glioblastoma 28903422 The E2F1-regulated miR-17/92 cluster and its analogs are shown to be highly expressed in proneural GBM and in GSC lines -other hsa-mir-18 Glioblastoma 28903422 The E2F1-regulated miR-17/92 cluster and its analogs are shown to be highly expressed in proneural GBM and in GSC lines -other hsa-mir-19a Glioblastoma 28903422 The E2F1-regulated miR-17/92 cluster and its analogs are shown to be highly expressed in proneural GBM and in GSC lines -other hsa-mir-19b-1 Glioblastoma 28903422 The E2F1-regulated miR-17/92 cluster and its analogs are shown to be highly expressed in proneural GBM and in GSC lines -other hsa-mir-20a Glioblastoma 28903422 The E2F1-regulated miR-17/92 cluster and its analogs are shown to be highly expressed in proneural GBM and in GSC lines -other hsa-mir-92-1 Glioblastoma 28903422 The E2F1-regulated miR-17/92 cluster and its analogs are shown to be highly expressed in proneural GBM and in GSC lines -other hsa-mir-17 "Carcinoma, Hepatocellular" 28904393 MicroRNA pharmacogenomics based integrated model of miR-17-92 cluster in sorafenib resistant HCC cells reveals a strategy to forestall drug resistance. -other hsa-mir-18 "Carcinoma, Hepatocellular" 28904393 MicroRNA pharmacogenomics based integrated model of miR-17-92 cluster in sorafenib resistant HCC cells reveals a strategy to forestall drug resistance. -other hsa-mir-19a "Carcinoma, Hepatocellular" 28904393 MicroRNA pharmacogenomics based integrated model of miR-17-92 cluster in sorafenib resistant HCC cells reveals a strategy to forestall drug resistance. -other hsa-mir-19b-1 "Carcinoma, Hepatocellular" 28904393 MicroRNA pharmacogenomics based integrated model of miR-17-92 cluster in sorafenib resistant HCC cells reveals a strategy to forestall drug resistance. -other hsa-mir-20a "Carcinoma, Hepatocellular" 28904393 MicroRNA pharmacogenomics based integrated model of miR-17-92 cluster in sorafenib resistant HCC cells reveals a strategy to forestall drug resistance. -other hsa-mir-92-1 "Carcinoma, Hepatocellular" 28904393 MicroRNA pharmacogenomics based integrated model of miR-17-92 cluster in sorafenib resistant HCC cells reveals a strategy to forestall drug resistance. -other hsa-mir-155 Neoplasms [unspecific] 28912267 Antitumor immunity is defective in T cell-specific microRNA-155-deficient mice and is rescued by immune checkpoint blockade. -other hsa-mir-124 Alzheimer Disease 28912710 "A¦Â downregulated miR-155 and miR-124, and reduced the CD11b+ subpopulation in 2 DIV microglia" -other hsa-mir-155 Alzheimer Disease 28912710 "A¦Â downregulated miR-155 and miR-124, and reduced the CD11b+ subpopulation in 2 DIV microglia" -other hsa-mir-375 "Carcinoma, Hepatocellular" 28915706 The role of autophagy in hepatocellular carcinoma: friend or foe. -other hsa-mir-31 Mesothelioma 28918032 MicroRNA-31 Regulates Chemosensitivity in Malignant Pleural Mesothelioma. -other hsa-mir-146a Lymphoma 28918474 Induction of Immunogenic Cell Death in Lymphoma Cells by Wharton's Jelly Mesenchymal Stem Cell Conditioned Medium. -other hsa-mir-222 "Squamous Cell Carcinoma, Skin or Unspecific" 28925390 Alterations of microRNAs throughout the malignant evolution of cutaneous squamous cell carcinoma: the role of miR-497 in epithelial to mesenchymal transition of keratinocytes. -other hsa-mir-7 Colorectal Carcinoma 28929494 CRHR2/Ucn2 signaling is a novel regulator of miR-7/YY1/Fas circuitry contributing to reversal of colorectal cancer cell resistance to Fas-mediated apoptosis. -other hsa-mir-223 Lung Injury [unspecific] 28931657 Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice. -other hsa-mir-335 Neoplasms [unspecific] 28932769 MicroRNA expression in a phosphaturic mesenchymal tumour. -other hsa-mir-143 Breast Neoplasms 28933584 Circular RNA hsa_circ_0001982 Promotes Breast Cancer Cell Carcinogenesis Through Decreasing miR-143. -other hsa-mir-181b Sepsis 28934717 the CCAAT enhancer-binding protein C/EBP¦Â activates microRNA (miR)-21 and miR-181b expressions -other hsa-mir-21 Sepsis 28934717 the CCAAT enhancer-binding protein C/EBP¦Â activates microRNA (miR)-21 and miR-181b expressions -other hsa-mir-221 Melanoma 28936555 Resveratrol suppresses melanoma by inhibiting NF-¦ÊB/miR-221 and inducing TFG expression. -other hsa-mir-125b Bladder Neoplasms 28938585 The trophoblast cell surface antigen 2 and miR-125b axis in urothelial bladder cancer. -other hsa-let-7d "Squamous Cell Carcinoma, Head and Neck" 28941018 "The available literature supports differential expression of both microRNAs and long non-coding RNAs, which include oncogenic ncRNAs (miR-21, miR-31, miR-155, miR-211, HOTAIR, and MALAT1) and tumor suppressor ncRNAs (let7d, miR-17, miR-375, miR-139, and MEG3) in HPV+ve HNSCC tumors as compared to HPV-ve tumors and they have distinct role in the pathophysiology of these two types of HNSCCs" -other hsa-mir-139 "Squamous Cell Carcinoma, Head and Neck" 28941018 "The available literature supports differential expression of both microRNAs and long non-coding RNAs, which include oncogenic ncRNAs (miR-21, miR-31, miR-155, miR-211, HOTAIR, and MALAT1) and tumor suppressor ncRNAs (let7d, miR-17, miR-375, miR-139, and MEG3) in HPV+ve HNSCC tumors as compared to HPV-ve tumors and they have distinct role in the pathophysiology of these two types of HNSCCs" -other hsa-mir-155 "Squamous Cell Carcinoma, Head and Neck" 28941018 "The available literature supports differential expression of both microRNAs and long non-coding RNAs, which include oncogenic ncRNAs (miR-21, miR-31, miR-155, miR-211, HOTAIR, and MALAT1) and tumor suppressor ncRNAs (let7d, miR-17, miR-375, miR-139, and MEG3) in HPV+ve HNSCC tumors as compared to HPV-ve tumors and they have distinct role in the pathophysiology of these two types of HNSCCs" -other hsa-mir-17 "Squamous Cell Carcinoma, Head and Neck" 28941018 "The available literature supports differential expression of both microRNAs and long non-coding RNAs, which include oncogenic ncRNAs (miR-21, miR-31, miR-155, miR-211, HOTAIR, and MALAT1) and tumor suppressor ncRNAs (let7d, miR-17, miR-375, miR-139, and MEG3) in HPV+ve HNSCC tumors as compared to HPV-ve tumors and they have distinct role in the pathophysiology of these two types of HNSCCs" -other hsa-mir-21 "Squamous Cell Carcinoma, Head and Neck" 28941018 "The available literature supports differential expression of both microRNAs and long non-coding RNAs, which include oncogenic ncRNAs (miR-21, miR-31, miR-155, miR-211, HOTAIR, and MALAT1) and tumor suppressor ncRNAs (let7d, miR-17, miR-375, miR-139, and MEG3) in HPV+ve HNSCC tumors as compared to HPV-ve tumors and they have distinct role in the pathophysiology of these two types of HNSCCs" -other hsa-mir-211 "Squamous Cell Carcinoma, Head and Neck" 28941018 "The available literature supports differential expression of both microRNAs and long non-coding RNAs, which include oncogenic ncRNAs (miR-21, miR-31, miR-155, miR-211, HOTAIR, and MALAT1) and tumor suppressor ncRNAs (let7d, miR-17, miR-375, miR-139, and MEG3) in HPV+ve HNSCC tumors as compared to HPV-ve tumors and they have distinct role in the pathophysiology of these two types of HNSCCs" -other hsa-mir-31 "Squamous Cell Carcinoma, Head and Neck" 28941018 "The available literature supports differential expression of both microRNAs and long non-coding RNAs, which include oncogenic ncRNAs (miR-21, miR-31, miR-155, miR-211, HOTAIR, and MALAT1) and tumor suppressor ncRNAs (let7d, miR-17, miR-375, miR-139, and MEG3) in HPV+ve HNSCC tumors as compared to HPV-ve tumors and they have distinct role in the pathophysiology of these two types of HNSCCs" -other hsa-mir-375 "Squamous Cell Carcinoma, Head and Neck" 28941018 "The available literature supports differential expression of both microRNAs and long non-coding RNAs, which include oncogenic ncRNAs (miR-21, miR-31, miR-155, miR-211, HOTAIR, and MALAT1) and tumor suppressor ncRNAs (let7d, miR-17, miR-375, miR-139, and MEG3) in HPV+ve HNSCC tumors as compared to HPV-ve tumors and they have distinct role in the pathophysiology of these two types of HNSCCs" -other hsa-mir-130a Coronary Artery Disease 28947970 Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients. -other hsa-mir-210 Myocardial Infarction 28948298 "MicroRNA-210-mediated proliferation, survival, and angiogenesis promote cardiac repair post myocardial infarction in rodents." -other hsa-mir-182 Glioma 28956430 The feasibility of the method for sensitive determination of miRNA-182 and miRNA-381 from serum samples of glioma patients at different stages was demonstrated -other hsa-mir-381 Glioma 28956430 The feasibility of the method for sensitive determination of miRNA-182 and miRNA-381 from serum samples of glioma patients at different stages was demonstrated -other hsa-mir-10a "Carcinoma, Hepatocellular" 28958640 "our data showed potential role of miR-10a, miR-30e, miR-215, miR-125b and miR-148a as important mediators in HCC progression" -other hsa-mir-125b "Carcinoma, Hepatocellular" 28958640 "our data showed potential role of miR-10a, miR-30e, miR-215, miR-125b and miR-148a as important mediators in HCC progression" -other hsa-mir-148a "Carcinoma, Hepatocellular" 28958640 "our data showed potential role of miR-10a, miR-30e, miR-215, miR-125b and miR-148a as important mediators in HCC progression" -other hsa-mir-215 "Carcinoma, Hepatocellular" 28958640 "our data showed potential role of miR-10a, miR-30e, miR-215, miR-125b and miR-148a as important mediators in HCC progression" -other hsa-mir-30e "Carcinoma, Hepatocellular" 28958640 "our data showed potential role of miR-10a, miR-30e, miR-215, miR-125b and miR-148a as important mediators in HCC progression" -other hsa-mir-138 "Squamous Cell Carcinoma, Oral" 28962163 "miR-138 is able to inhibit the proliferation, migration and invasion of OSCC cell lines" -other hsa-mir-675 Dental Enamel Hypoplasia 28963438 DLX3 promotes bone marrow mesenchymal stem cell proliferation through H19/miR-675 axis. -other hsa-mir-16 Lymphoma 28976967 A viral Sm-class RNA base-pairs with mRNAs and recruits microRNAs to inhibit apoptosis. -other hsa-mir-1224 Leukemia 28977780 a similar expression pattern of hsa-miR-1224-3p and hsa-miR-21 were observed in urine samples collected from human leukemia patients preconditioned with TBI -other hsa-mir-21 Leukemia 28977780 a similar expression pattern of hsa-miR-1224-3p and hsa-miR-21 were observed in urine samples collected from human leukemia patients preconditioned with TBI -other hsa-mir-30d Mesothelioma 28979837 miR-30d is related to asbestos exposure and inhibits migration and invasion in NCI-H2452 cells. -other hsa-mir-145 Myocardial Infarction 28980287 Inducible miR-145 expression by HIF-1a protects cardiomyocytes against apoptosis via regulating SGK1 in simulated myocardial infarction hypoxic microenvironment. -other hsa-mir-1 Cardiomegaly 28985746 Porcine model of progressive cardiac hypertrophy and fibrosis with secondary postcapillary pulmonary hypertension. -other hsa-mir-29a Cardiomegaly 28985746 Porcine model of progressive cardiac hypertrophy and fibrosis with secondary postcapillary pulmonary hypertension. -other hsa-mir-7 "Leukemia, Myeloid, Chronic" 28986256 MicroRNA-7 inhibits cell proliferation of chronic myeloid leukemia and sensitizes it to imatinib in?vitro. -other hsa-mir-433 Parkinson Disease 28986288 Linking down-regulation of miRNA-7 and miRNA-433 with ¦Á-synuclein overexpression and risk of idiopathic Parkinson's disease. -other hsa-mir-7 Parkinson Disease 28986288 Linking down-regulation of miRNA-7 and miRNA-433 with ¦Á-synuclein overexpression and risk of idiopathic Parkinson's disease. -other hsa-mir-146a Gastric Neoplasms 28987948 MiR-146a functions as a small silent player in gastric cancer. -other hsa-mir-10b Neoplasms [unspecific] 28989695 Simultaneous visualization of the subfemtomolar expression of microRNA and microRNA target gene using HILO microscopy. -other hsa-mir-21 Glioblastoma 29023168 Development and characterization of cationic solid lipid nanoparticles for co-delivery of pemetrexed and miR-21 antisense oligonucleotide to glioblastoma cells. -other hsa-mir-132 Heart Failure 29027324 Circulating microRNA-132 levels improve risk prediction for heart failure hospitalization in patients with chronic heart failure. -other hsa-mir-200c Neoplasms [unspecific] 29029445 MicroRNA-200c increases radiosensitivity of human cancer cells with activated EGFR-associated signaling. -other hsa-mir-192 "Diabetes Mellitus, Type 2" 29040025 "Lower concentrations of miR-192 and miR-375 were also found, which correlated positively with HOMA-IR" -other hsa-mir-375 "Diabetes Mellitus, Type 2" 29040025 "Lower concentrations of miR-192 and miR-375 were also found, which correlated positively with HOMA-IR" -other hsa-mir-181a Melanoma 29041990 Piceatannol induced apoptosis through up-regulation of microRNA-181a in melanoma cells. -other hsa-mir-326 Multiple Sclerosis 29043654 "Evaluation of Selected MicroRNAs Expression in Remission Phase of Multiple Sclerosis and Their Potential Link to Cognition, Depression, and Disability." -other hsa-mir-181b Cystic Fibrosis 29044225 microRNA-181b is increased in cystic fibrosis cells and impairs lipoxin A4 receptor-dependent mechanisms of inflammation resolution and antimicrobial defense. -other hsa-mir-27b Brain Disease [unspecific] 29050310 MicroRNA-27b inhibition promotes Nrf2/ARE pathway activation and alleviates intracerebral hemorrhage-induced brain injury -other hsa-mir-206 Myocardial Infarction 29055786 Carbon monoxide releasing molecule improves structural and functional cardiac recovery after myocardial injury. -other hsa-mir-155 "Carcinoma, Renal Cell" 29056573 Noncoding RNA Expression and Targeted Next-Generation Sequencing Distinguish Tubulocystic Renal Cell Carcinoma (TC-RCC) from Other Renal Neoplasms. -other hsa-mir-21 Melanoma 29058784 MicroRNA-21 antisense oligonucleotide improves the sensitivity of A375 human melanoma cell to Cisplatin -other hsa-mir-30a "Carcinoma, Hepatocellular" 29061507 MicroRNA-30a suppresses autophagy-mediated anoikis resistance and metastasis in hepatocellular carcinoma. -other hsa-mir-22 Myocardial Infarction 29063105 miR-22 plays critical roles in MI and subsequent cardiac remodeling -other hsa-mir-375 Colorectal Carcinoma 29068474 The PI3K/AKT signaling pathway: Associations of miRNAs with dysregulated gene expression in colorectal cancer. -other hsa-let-7i Infection [unspecific] 29069656 Cyclosporine A Induces MicroRNAs Controlling Innate Immunity during Renal Bacterial Infection. -other hsa-mir-148a Ovarian Neoplasms 29069830 "The selected signature composed by VAT1L, CALR, LINC01456, RP11-484L8.1, MIR196A1 and MIR148A, separated the training group patients into high-risk or low-risk subgroup with significantly different survival time" -other hsa-mir-196a-1 Ovarian Neoplasms 29069830 "The selected signature composed by VAT1L, CALR, LINC01456, RP11-484L8.1, MIR196A1 and MIR148A, separated the training group patients into high-risk or low-risk subgroup with significantly different survival time" -other hsa-mir-21 "Carcinoma, Renal Cell" 29070781 Cordycepin induces apoptotic cell death and inhibits cell migration in renal cell carcinoma via regulation of microRNA-21 and PTEN phosphatase. -other hsa-mir-124 Neuroblastoma 29073265 MiRNA-124 is a link between measles virus persistent infection and cell division of human neuroblastoma cells. -other hsa-mir-9 "Squamous Cell Carcinoma, Oral" 29073835 miR-9 induces cell arrest and apoptosis of oral squamous cell carcinoma via CDK 4/6 pathway. -other hsa-mir-155 Neuroinflammation 29079998 Role of 3-Acetyl-11-Keto-Beta-Boswellic Acid in Counteracting LPS-Induced Neuroinflammation via Modulation of miRNA-155. -other hsa-mir-378 Glioblastoma 29081036 MicroRNA-378 enhances radiation response in ectopic and orthotopic implantation models of glioblastoma. -other hsa-mir-122 Chronic Hepatitis C 29084265 miRNA independent hepacivirus variants suggest a strong evolutionary pressure to maintain miR-122 dependence. -other hsa-mir-15a Laryngeal Neoplasms 29085504 "Curcumin inhibits cell proliferation and promotes apoptosis of laryngeal cancer cells through Bcl-2 and PI3K/Akt, and by upregulating miR-15a." -other hsa-mir-29b Brain Disease [unspecific] 29087603 MiR-29b expression is associated with a dexmedetomidine-mediated protective effect against oxygen-glucose deprivation-induced injury to SK-N-SH cells in vitro. -other hsa-mir-138 "Squamous Cell Carcinoma, Oral" 29088820 "Knockdown of fascin in OSCC cells promoted cell adhesion and inhibited migration, invasion and EMT, and forced expression of miR-138 in OSCC cells significantly decreased the expression of fascin" -other hsa-mir-21 Liver Neoplasms 29091291 Genetic and pharmacologic manipulation of miR-21 does not inhibit the development of liver fibrosis and liver cancer -other hsa-mir-1 Myocardial Infarction 29094045 Effect of Wenxin Granules on Gap Junction and MiR-1 in Rats with Myocardial Infarction. -other hsa-mir-140 Osteoarthritis 29095952 Computer simulation models as a tool to investigate the role of microRNAs in osteoarthritis. -other hsa-mir-222 Gastric Neoplasms 29098549 The GAS5/miR-222 Axis Regulates Proliferation of Gastric Cancer Cells Through the PTEN/Akt/mTOR Pathway. -other hsa-mir-24 Breast Neoplasms 29103019 Propofol induces apoptosis of breast cancer cells by downregulation of miR-24 signal pathway. -other hsa-mir-155 Allergic Asthma 29104649 Small interfering RNA directed against microRNA-155 delivered by a lentiviral vector attenuates asthmatic features in a mouse model of allergic asthma. -other hsa-mir-34a "Carcinoma, Renal Cell" 29104726 MicroRNA-34a: A Key Regulator in the Hallmarks of Renal Cell Carcinoma. -other hsa-mir-676 Hypohidrotic Ectodermal Dysplasia 29106399 A microRNA screen reveals that elevated hepatic ectodysplasin A expression contributes to obesity-induced insulin resistance in skeletal muscle. -other hsa-mir-132 Salivary Gland Neoplasms 29108921 "miR-17, miR-132, miR-195 and miR-221 seem to play an important role as tumor suppressor in salivary gland tumors" -other hsa-mir-17 Salivary Gland Neoplasms 29108921 "miR-17, miR-132, miR-195 and miR-221 seem to play an important role as tumor suppressor in salivary gland tumors" -other hsa-mir-195 Salivary Gland Neoplasms 29108921 "miR-17, miR-132, miR-195 and miR-221 seem to play an important role as tumor suppressor in salivary gland tumors" -other hsa-mir-221 Salivary Gland Neoplasms 29108921 "miR-17, miR-132, miR-195 and miR-221 seem to play an important role as tumor suppressor in salivary gland tumors" -other hsa-mir-210 Stroke 29111308 Inhibition of microRNA-210 suppresses pro-inflammatory response and reduces acute brain injury of ischemic stroke in mice. -other hsa-mir-10a Breast Neoplasms 29113237 MicroRNA-10a suppresses breast cancer progression via PI3K/Akt/mTOR pathway. -other hsa-mir-1 Heart Failure 29117535 Rescuing infusion of miRNA-1 prevents cardiac remodeling in a heart-selective miRNA deficient mouse. -other hsa-mir-17 Allergy 29122948 MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation. -other hsa-mir-34a "Carcinoma, Hepatocellular" 29128099 Regulation of Cellular Senescence by miR-34a in Alcoholic Liver Injury. -other hsa-mir-214 Gastric Neoplasms 29129783 Hypoxia-induced miR-214 expression promotes tumour cell proliferation and migration by enhancing the Warburg effect in gastric carcinoma cells. -other hsa-mir-16 "Carcinoma, Hepatocellular" 29136911 "microRNA-155 expression, essential in NK cell activation, was elevated in Foxo3-/- NK cells while its inhibition led to diminished IFN¦Ã production" -other hsa-mir-145 "Adenocarcinoma, Pancreatic Ductal" 29137251 Exportin 1 (XPO1) inhibition leads to restoration of tumor suppressor miR-145 and consequent suppression of pancreatic cancer cell proliferation and migration. -other hsa-mir-146a Status Epilepticus 29144992 Intracerebroventricular injection of miR-146a relieves seizures in an immature rat model of lithium-pilocarpine induced status epilepticus. -other hsa-mir-223 Hepatitis [unspecific] 29145157 BMSCs-derived miR-223-containing exosomes contribute to liver protection in experimental autoimmune hepatitis -other hsa-mir-21 Salivary Gland Disease 29154818 MicroRNA-21 promotes wound healing via the Smad7-Smad2/3-Elastin pathway. -other hsa-mir-221 Leukemia 29156756 "Increasing knowledge of biological changes, due to altered miRNA dynamics, is expected to have relevant translational implications for leukemia detection and treatment" -other hsa-mir-20a "Lymphoma, Large B-Cell, Diffuse" 29156774 MicroRNAs as predictors for CNS relapse of systemic diffuse large B-cell lymphoma -other hsa-mir-21 Multiple Myeloma 29158801 Gambogenic Acid Exerts Antitumor Activity in Hypoxic Multiple Myeloma Cells by Regulation of miR-21 -other hsa-mir-503 Bladder Neoplasms 29169421 miR-503-5p inhibits the proliferation of T24 and EJ bladder cancer cells by interfering with the Rb/E2F signaling pathway -other hsa-let-7b Alzheimer Disease 29170128 let-7b has an important association with the pathology of AD and can be used as an adjunct to improve the diagnostic performance of traditional AD biomarkers -other hsa-mir-21 Ischemia-Reperfusion Injury 29170412 Ischemic Postconditioning Protects Against Intestinal Ischemia/Reperfusion Injury via the HIF-1¦Á/miR-21 Axis -other hsa-mir-146a Human Papilloma Virus Infection 29181576 "HPV16 induces the overexpression of miR-146a in the initial stages of carcinogenesis (hyperplasia and dysplasia), whereas decreases its expression at later stages (CIS)" -other hsa-mir-21 Gastric Neoplasms 29185784 miR-21 Inhibitors Modulate Biological Functions of Gastric Cancer Cells via PTEN/PI3K/mTOR Pathway -other hsa-mir-21 Ischemia-Reperfusion Injury 29187695 the activation of the Akt pathway regulated by miR-21 participates in the protective effects of H2S against I/R-induced liver injury -other hsa-mir-133a Asthma 29191361 "The relative expression of miRNA-133a increased in the low-dose anti-IgE, high-dose anti-IgE, fluticasone+anti-IgE and anti-TNF groups" -other hsa-mir-106b Multiple Sclerosis 29194612 "our data revealed that the expression of a number of microRNAs including miR-16, miR-17-92, miR-27, miR-29b, miR-126, miR-128, miR-132, miR-155, miR-326, miR-550, miR-15a, miR-19b, miR-106b, miR-320a, miR-363, miR-31, miR-150, and miR-340 is regulated by nanocurcumin" -other hsa-mir-126 Multiple Sclerosis 29194612 "our data revealed that the expression of a number of microRNAs including miR-16, miR-17-92, miR-27, miR-29b, miR-126, miR-128, miR-132, miR-155, miR-326, miR-550, miR-15a, miR-19b, miR-106b, miR-320a, miR-363, miR-31, miR-150, and miR-340 is regulated by nanocurcumin" -other hsa-mir-128 Multiple Sclerosis 29194612 "our data revealed that the expression of a number of microRNAs including miR-16, miR-17-92, miR-27, miR-29b, miR-126, miR-128, miR-132, miR-155, miR-326, miR-550, miR-15a, miR-19b, miR-106b, miR-320a, miR-363, miR-31, miR-150, and miR-340 is regulated by nanocurcumin" -other hsa-mir-132 Multiple Sclerosis 29194612 "our data revealed that the expression of a number of microRNAs including miR-16, miR-17-92, miR-27, miR-29b, miR-126, miR-128, miR-132, miR-155, miR-326, miR-550, miR-15a, miR-19b, miR-106b, miR-320a, miR-363, miR-31, miR-150, and miR-340 is regulated by nanocurcumin" -other hsa-mir-150 Multiple Sclerosis 29194612 "our data revealed that the expression of a number of microRNAs including miR-16, miR-17-92, miR-27, miR-29b, miR-126, miR-128, miR-132, miR-155, miR-326, miR-550, miR-15a, miR-19b, miR-106b, miR-320a, miR-363, miR-31, miR-150, and miR-340 is regulated by nanocurcumin" -other hsa-mir-155 Multiple Sclerosis 29194612 "our data revealed that the expression of a number of microRNAs including miR-16, miR-17-92, miR-27, miR-29b, miR-126, miR-128, miR-132, miR-155, miR-326, miR-550, miR-15a, miR-19b, miR-106b, miR-320a, miR-363, miR-31, miR-150, and miR-340 is regulated by nanocurcumin" -other hsa-mir-15a Multiple Sclerosis 29194612 "our data revealed that the expression of a number of microRNAs including miR-16, miR-17-92, miR-27, miR-29b, miR-126, miR-128, miR-132, miR-155, miR-326, miR-550, miR-15a, miR-19b, miR-106b, miR-320a, miR-363, miR-31, miR-150, and miR-340 is regulated by nanocurcumin" -other hsa-mir-16 Multiple Sclerosis 29194612 "our data revealed that the expression of a number of microRNAs including miR-16, miR-17-92, miR-27, miR-29b, miR-126, miR-128, miR-132, miR-155, miR-326, miR-550, miR-15a, miR-19b, miR-106b, miR-320a, miR-363, miR-31, miR-150, and miR-340 is regulated by nanocurcumin" -other hsa-mir-17 Multiple Sclerosis 29194612 "our data revealed that the expression of a number of microRNAs including miR-16, miR-17-92, miR-27, miR-29b, miR-126, miR-128, miR-132, miR-155, miR-326, miR-550, miR-15a, miR-19b, miR-106b, miR-320a, miR-363, miR-31, miR-150, and miR-340 is regulated by nanocurcumin" -other hsa-mir-18 Multiple Sclerosis 29194612 "our data revealed that the expression of a number of microRNAs including miR-16, miR-17-92, miR-27, miR-29b, miR-126, miR-128, miR-132, miR-155, miR-326, miR-550, miR-15a, miR-19b, miR-106b, miR-320a, miR-363, miR-31, miR-150, and miR-340 is regulated by nanocurcumin" -other hsa-mir-19a Multiple Sclerosis 29194612 "our data revealed that the expression of a number of microRNAs including miR-16, miR-17-92, miR-27, miR-29b, miR-126, miR-128, miR-132, miR-155, miR-326, miR-550, miR-15a, miR-19b, miR-106b, miR-320a, miR-363, miR-31, miR-150, and miR-340 is regulated by nanocurcumin" -other hsa-mir-19b Multiple Sclerosis 29194612 "our data revealed that the expression of a number of microRNAs including miR-16, miR-17-92, miR-27, miR-29b, miR-126, miR-128, miR-132, miR-155, miR-326, miR-550, miR-15a, miR-19b, miR-106b, miR-320a, miR-363, miR-31, miR-150, and miR-340 is regulated by nanocurcumin" -other hsa-mir-19b-1 Multiple Sclerosis 29194612 "our data revealed that the expression of a number of microRNAs including miR-16, miR-17-92, miR-27, miR-29b, miR-126, miR-128, miR-132, miR-155, miR-326, miR-550, miR-15a, miR-19b, miR-106b, miR-320a, miR-363, miR-31, miR-150, and miR-340 is regulated by nanocurcumin" -other hsa-mir-20a Multiple Sclerosis 29194612 "our data revealed that the expression of a number of microRNAs including miR-16, miR-17-92, miR-27, miR-29b, miR-126, miR-128, miR-132, miR-155, miR-326, miR-550, miR-15a, miR-19b, miR-106b, miR-320a, miR-363, miR-31, miR-150, and miR-340 is regulated by nanocurcumin" -other hsa-mir-27 Multiple Sclerosis 29194612 "our data revealed that the expression of a number of microRNAs including miR-16, miR-17-92, miR-27, miR-29b, miR-126, miR-128, miR-132, miR-155, miR-326, miR-550, miR-15a, miR-19b, miR-106b, miR-320a, miR-363, miR-31, miR-150, and miR-340 is regulated by nanocurcumin" -other hsa-mir-29b Multiple Sclerosis 29194612 "our data revealed that the expression of a number of microRNAs including miR-16, miR-17-92, miR-27, miR-29b, miR-126, miR-128, miR-132, miR-155, miR-326, miR-550, miR-15a, miR-19b, miR-106b, miR-320a, miR-363, miR-31, miR-150, and miR-340 is regulated by nanocurcumin" -other hsa-mir-31 Multiple Sclerosis 29194612 "our data revealed that the expression of a number of microRNAs including miR-16, miR-17-92, miR-27, miR-29b, miR-126, miR-128, miR-132, miR-155, miR-326, miR-550, miR-15a, miR-19b, miR-106b, miR-320a, miR-363, miR-31, miR-150, and miR-340 is regulated by nanocurcumin" -other hsa-mir-320a Multiple Sclerosis 29194612 "our data revealed that the expression of a number of microRNAs including miR-16, miR-17-92, miR-27, miR-29b, miR-126, miR-128, miR-132, miR-155, miR-326, miR-550, miR-15a, miR-19b, miR-106b, miR-320a, miR-363, miR-31, miR-150, and miR-340 is regulated by nanocurcumin" -other hsa-mir-326 Multiple Sclerosis 29194612 "our data revealed that the expression of a number of microRNAs including miR-16, miR-17-92, miR-27, miR-29b, miR-126, miR-128, miR-132, miR-155, miR-326, miR-550, miR-15a, miR-19b, miR-106b, miR-320a, miR-363, miR-31, miR-150, and miR-340 is regulated by nanocurcumin" -other hsa-mir-340 Multiple Sclerosis 29194612 "our data revealed that the expression of a number of microRNAs including miR-16, miR-17-92, miR-27, miR-29b, miR-126, miR-128, miR-132, miR-155, miR-326, miR-550, miR-15a, miR-19b, miR-106b, miR-320a, miR-363, miR-31, miR-150, and miR-340 is regulated by nanocurcumin" -other hsa-mir-363 Multiple Sclerosis 29194612 "our data revealed that the expression of a number of microRNAs including miR-16, miR-17-92, miR-27, miR-29b, miR-126, miR-128, miR-132, miR-155, miR-326, miR-550, miR-15a, miR-19b, miR-106b, miR-320a, miR-363, miR-31, miR-150, and miR-340 is regulated by nanocurcumin" -other hsa-mir-550 Multiple Sclerosis 29194612 "our data revealed that the expression of a number of microRNAs including miR-16, miR-17-92, miR-27, miR-29b, miR-126, miR-128, miR-132, miR-155, miR-326, miR-550, miR-15a, miR-19b, miR-106b, miR-320a, miR-363, miR-31, miR-150, and miR-340 is regulated by nanocurcumin" -other hsa-mir-92-1 Multiple Sclerosis 29194612 "our data revealed that the expression of a number of microRNAs including miR-16, miR-17-92, miR-27, miR-29b, miR-126, miR-128, miR-132, miR-155, miR-326, miR-550, miR-15a, miR-19b, miR-106b, miR-320a, miR-363, miR-31, miR-150, and miR-340 is regulated by nanocurcumin" -other hsa-mir-204 Hypertension 29196166 "1,25(OH)2D3 was a promising therapeutic modality for treatment of PAH, function of which was exerted through miR-204 mediated Tgfbr2 signaling" -other hsa-mir-1273g Diabetic Retinopathy 29197896 miRNA-1273g-3p Involvement in Development of Diabetic Retinopathy by Modulating the Autophagy-Lysosome Pathway. -other hsa-mir-126 Atherosclerosis 29203244 MicroRNA-126 alleviates endothelial cells injury in atherosclerosis by restoring autophagic flux via inhibiting of PI3K/Akt/mTOR pathway -other hsa-mir-15b Alzheimer Disease 29207665 miR-15b play an important role in the cellular AD phenotype and might be involved in the pathogenesis of AD -other hsa-mir-211 Cone Dystrophy 29209045 MiR-211 is essential for adult cone photoreceptor maintenance and visual function. -other hsa-mir-1 Myocardial Infarction 29212255 "Soluble epoxide hydrolase inhibitors, t-AUCB, regulated microRNA-1 and its target genes in myocardial infarction mice" -other hsa-mir-155 Breast Neoplasms 29214365 "Profiling differential microRNA expression between in situ, infiltrative and lympho-vascular space invasive breast cancer: a pilot study" -other hsa-mir-10a Alzheimer Disease 29215712 miR-10a restrains synapse remodeling and neuronal cell proliferation while promoting apoptosis in AD rats via inhibiting BDNF-TrkB signaling pathway -other hsa-mir-193a Prostate Neoplasms 29216925 Silencing of miR-193a-5p increases the chemosensitivity of prostate cancer cells to docetaxel. -other hsa-mir-29a Neoplasms [unspecific] 29217524 "we discussed the functions of miR-29a and its potential application in the diagnosis, treatment and stages of carcinoma, which could provide additional insight to develop a novel therapeutic strategy" -other hsa-mir-124 Stroke 29221142 D-4F increases microRNA-124a and reduces neuroinflammation in diabetic stroke rats -other hsa-mir-130a Colon Neoplasms 29225578 Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/¦Â-Catenin Pathways via miR-130a -other hsa-mir-34a Breast Neoplasms 29226432 the intracellular function of miR-34a delivered by the nanocomplex to upregulate active Caspase-3 was imaged in real-time -other hsa-mir-155 Lymphoma 29228427 MiR-155 regulates lymphoma cell proliferation and apoptosis through targeting SOCS3/JAK-STAT3 signaling pathway -other hsa-mir-204 Prostate Neoplasms 29228612 MiR-204 enhances mitochondrial apoptosis in doxorubicin-treated prostate cancer cells by targeting SIRT1/p53 pathway -other hsa-mir-21 Liver Injury 29229992 miRNA-21 ablation protects against liver injury and necroptosis in cholestasis -other hsa-mir-128 Asthma 29231896 Downregulated miR-128 and miR-744 supports a Th2/Th17 type immune response in severe equine asthma -other hsa-mir-744 Asthma 29231896 Downregulated miR-128 and miR-744 supports a Th2/Th17 type immune response in severe equine asthma -other hsa-mir-126 Ischemia 29242072 Therapeutic angiogenesis by local sustained release of microRNA-126 using poly lactic-co-glycolic acid nanoparticles in murine hindlimb ischemia -other hsa-mir-27b Endometriosis 29247225 "Rg3 effectively altered fibrotic properties of HESCs from patients with endometriosis, which is likely associated with miR-27b-3p modulation" -other hsa-mir-124 "Carcinoma, Pancreatic" 29255366 circRNA_100782 regulates BxPC3 cell proliferation by acting as miR-124 sponge through the IL6-STAT3 pathway -other hsa-mir-30a "Squamous Cell Carcinoma, Esophageal" 29259372 Down-regulation of miR-30a-3p/5p promotes esophageal squamous cell carcinoma cell proliferation by activating the Wnt signaling pathway -other hsa-mir-144 Melanoma 29260980 Baohuoside-I suppresses cell proliferation and migration by up-regulating miR-144 in melanoma -other hsa-mir-155 Crohn Disease 29263823 a small subset had inflammatory responses almost comparable to wild-type patients on both gene and miR-155 regulatory levels -other hsa-mir-145 "Carcinoma, Lung, Non-Small-Cell" 29266356 Effect of microRNA-145 on proliferation and apoptosis of human non-small cell lung cancer A549 cells by regulating mTOR signaling pathway -other hsa-mir-320 IgA Nephropathy 29266359 MiR-320 promotes B cell proliferation and the production of aberrant glycosylated IgA1 in IgA nephropathy. -other hsa-mir-146a "Squamous Cell Carcinoma, Oral" 29269299 the activation of TLR2 by bacterial components can enhance the progression of OSCC and may be implicated in acquired resistance to cisplatin-induced apoptosis through regulation of the miR-146a pathway -other hsa-mir-144 Anemia 29269522 miR-144/451 represses the LKB1/AMPK/mTOR pathway to promote red cell precursor survival during recovery from acute anemia -other hsa-mir-221 Prostate Neoplasms 29281088 "Combining radiation dose parameters with microRNA expression in PBLs may be useful for predicting acute gastrointestinal toxicity of radiation therapy, thus contributing to personalized treatment of prostate cancer" -other hsa-mir-21 Allergic Contact Dermatitis 29282578 "MicroRNA-21-Mediated Inhibition of Mast Cell Degranulation Involved in the Protective Effect of Berberine on 2,4-Dinitrofluorobenzene-Induced Allergic Contact Dermatitis in Rats via p38 Pathway" -other hsa-mir-503 Diabetes Mellitus 29285014 microRNA-503 contribute to pancreatic beta cell dysfunction by targeting the mTOR pathway in gestational diabetes mellitus -other hsa-mir-106b Cholangiocarcinoma 29286255 miR-106b-responsive gene landscape identifies regulation of Kruppel-like factor family -other hsa-mir-214 "Adenocarcinoma, Lung" 29288987 Machine Learning Based Prediction of Brain Metastasis of Patients with IIIA-N2 Lung Adenocarcinoma by a Three-miRNA Signature -other hsa-mir-146a Osteoarthritis 29292727 the modification of miR-146a and miR-34a in OA chondrocytes subjected to H2O2 stimulus and we confirmed the antioxidant effect of taurine -other hsa-mir-34a Osteoarthritis 29292727 the modification of miR-146a and miR-34a in OA chondrocytes subjected to H2O2 stimulus and we confirmed the antioxidant effect of taurine -other hsa-mir-34a Pancreatic Neoplasms 29295989 Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer -other hsa-mir-21 Neurilemmoma 29298734 Ailanthone promotes human vestibular schwannoma cells apoptosis and autophagy by down-regulation of miR-21 -other hsa-mir-16 Coronary Artery Disease 29306454 "HDLs are depleted of miR-16, miR-92a and miR-223 during the transcoronary passage in patients with ACS compared to patients with stable CAD" -other hsa-mir-223 Coronary Artery Disease 29306454 "HDLs are depleted of miR-16, miR-92a and miR-223 during the transcoronary passage in patients with ACS compared to patients with stable CAD" -other hsa-mir-92a Coronary Artery Disease 29306454 "HDLs are depleted of miR-16, miR-92a and miR-223 during the transcoronary passage in patients with ACS compared to patients with stable CAD" -other hsa-mir-21 Multiple Myeloma 29320977 Ibrutinib targets microRNA-21 in multiple myeloma cells by inhibiting NF-¦ÊB and STAT3 -other hsa-mir-212 Prostate Neoplasms 29321092 MicroRNA-212 Targets Mitogen-Activated Protein Kinase 1 to Inhibit Proliferation and Invasion of Prostate Cancer Cells. -other hsa-mir-130a Hepatitis C Virus Infection 29321333 MicroRNA 130a Regulates both Hepatitis C Virus and Hepatitis B Virus Replication through a Central Metabolic Pathway. -other hsa-mir-15a Mitochondrial Metabolism Disease 29322081 Data of expression status of miR-29a and its putative target mitochondrial apoptosis regulatory gene DRP1 upon miR-15a and miR-214 inhibition -other hsa-mir-214 Mitochondrial Metabolism Disease 29322081 Data of expression status of miR-29a and its putative target mitochondrial apoptosis regulatory gene DRP1 upon miR-15a and miR-214 inhibition -other hsa-mir-221 "Carcinoma, Hepatocellular" 29322790 miR-221 and miR-222 might affect the pathogenesis of HCC -other hsa-mir-222 "Carcinoma, Hepatocellular" 29322790 miR-221 and miR-223 might affect the pathogenesis of HCC -other hsa-mir-1 Myocardial Infarction 29324314 "up-regulation of miR-1 and miR-208 in remote myocardium might play a role in cardiac remodeling after MI, at least to certain degree" -other hsa-mir-208 Myocardial Infarction 29324314 "up-regulation of miR-1 and miR-208 in remote myocardium might play a role in cardiac remodeling after MI, at least to certain degree" -other hsa-mir-181b "Adenocarcinoma, Lung" 29324442 ZEB1 initiates a miR-181b-regulated ceRNA network to drive metastasis -other hsa-mir-184 Age-Related Macular Degeneration 29325388 "miR-184 plays crucial regulatory roles in several ocular diseases, such as neovascularization, keratoconus, endothelial dystrophy, iris hypoplasia, congenital cataract, stromal thinning syndrome, corneal squamous cell carcinoma, age-related macular degeneration and cataract" -other hsa-mir-184 Cataract 29325388 "miR-184 plays crucial regulatory roles in several ocular diseases, such as neovascularization, keratoconus, endothelial dystrophy, iris hypoplasia, congenital cataract, stromal thinning syndrome, corneal squamous cell carcinoma, age-related macular degeneration and cataract" -other hsa-mir-184 Cornea Squamous Cell Carcinoma 29325388 "miR-184 plays crucial regulatory roles in several ocular diseases, such as neovascularization, keratoconus, endothelial dystrophy, iris hypoplasia, congenital cataract, stromal thinning syndrome, corneal squamous cell carcinoma, age-related macular degeneration and cataract" -other hsa-mir-122 Chronic Hepatitis C 29327233 DCAF1 is involved in HCV replication through regulation of miR-122 and thus provides new insights into the interaction between HCV and the host cell -other hsa-mir-203 "Carcinoma, Endometrial" 29331043 Role of miR-203 in estrogen receptor-mediated signaling in the rat uterus and endometrial carcinoma -other hsa-mir-146a Multiple Myeloma 29333170 Multiple Myeloma-Derived Exosomes Regulate the Functions of Mesenchymal Stem Cells Partially via Modulating miR-21 and miR-146a -other hsa-mir-21 Multiple Myeloma 29333170 Multiple Myeloma-Derived Exosomes Regulate the Functions of Mesenchymal Stem Cells Partially via Modulating miR-21 and miR-146a -other hsa-mir-466 Colorectal Carcinoma 29338680 MicroRNA-466 (miR-466) functions as a tumor suppressor and prognostic factor in colorectal cancer (CRC). -other hsa-mir-122 Chronic Hepatitis C 29343570 the 5'-proximal EHcV-specific region enhances viral replication and RNA stability in a miR-122-independent manner -other hsa-mir-16 "Carcinoma, Hepatocellular" 29344256 Pien Tze Huang inhibits the growth of hepatocellular carcinoma cells by upregulating miR-16 expression -other hsa-mir-155 Hepatitis B Virus Infection 29349567 HBeAg induces the expression of macrophage miR-155 to accelerate liver injury via promoting production of inflammatory cytokines. -other hsa-mir-17 Glioma 29351283 "The reduced miR-17 levels in glioma cells increased cell viability and migration, which correlates with increased expression of Cyclin D1, p-Akt and Akt" -other hsa-mir-125b Inflammation 29354323 "Up-Regulation of the Pro-Inflammatory Cytokines IL-6 and TNF¦Á, C-Reactive Protein (CRP) and miRNA-146a in Blood Serum" -other hsa-mir-146b Sciatic Nerve Injury 29356943 Inhibition of KLF7-Targeting MicroRNA 146b Promotes Sciatic Nerve Regeneration. -other hsa-mir-193a Wilms Tumor 29357419 Modulation of apolipoprotein L1-microRNA-193a axis prevents podocyte dedifferentiation in high-glucose milieu. -other hsa-mir-143 Colon Neoplasms 29360852 miR-143 might circumvent resistance of colon cancer cells to oxaliplatin via increased oxidative stress in HCT116 human colon cancer cells -other hsa-mir-145 "Carcinoma, Colon" 29360852 We show that approximately 100 proteins are differentially expressed in HCT116 human colon cancer cells stably transduced with miR-143 or miR-145 compared to Empty control cells -other hsa-mir-18a Hypoxia 29363860 ACE-EPCs-EXs have better protective effects on H/R injury in ageing ECs which could be through their carried miR-18a and subsequently down-regulating the Nox2/ROS pathway -other hsa-mir-31 Prostate Neoplasms 29364469 Estramustine phosphate induces prostate cancer cell line PC3 apoptosis by down-regulating miR-31 levels -other hsa-mir-155 Neoplasms [unspecific] 29366836 Increased miR-155 expression was associated with poorer survival in human carcinoma and as such may be valuable in predicting outcome -other hsa-mir-31 "Adenocarcinoma, Lung" 29367106 down-regulation of MIR31HG had no effect on the expression of miR-31 in lung adenocarcinoma cells -other hsa-mir-221 Alveolar Rhabdomyosarcoma 29367756 PAX3-FOXO1 drives miR-486-5p and represses miR-221 contributing to pathogenesis of alveolar rhabdomyosarcoma. -other hsa-mir-486 Alveolar Rhabdomyosarcoma 29367756 PAX3-FOXO1 drives miR-486-5p and represses miR-221 contributing to pathogenesis of alveolar rhabdomyosarcoma. -other hsa-mir-372 Neoplasms [unspecific] 29374231 Modulation of oncogenic miRNA biogenesis using functionalized polyamines -other hsa-mir-31 Medulloblastoma 29377269 Ginsenoside Rh2 inhibits proliferation and migration of medulloblastoma Daoy by down-regulation of microRNA-31 -other hsa-mir-124 Pediatric Ependymoma 29383182 "The tumor suppressor, hsa-miR-124, was down regulated in pediatric SEPN and it normally represses genes involved in cell-cell communication and metabolic processes" -other hsa-mir-17 Bladder Neoplasms 29386015 "Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression" -other hsa-mir-224 Bladder Neoplasms 29386015 "Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression" -other hsa-mir-224 "Carcinoma, Lung, Non-Small-Cell" 29387235 "Predictive relevance of miR-34a, miR-224 and miR-342 in patients with advanced squamous cell carcinoma of the lung undergoing palliative chemotherapy" -other hsa-mir-342 "Carcinoma, Lung, Non-Small-Cell" 29387235 "Predictive relevance of miR-34a, miR-224 and miR-342 in patients with advanced squamous cell carcinoma of the lung undergoing palliative chemotherapy" -other hsa-mir-34a "Carcinoma, Lung, Non-Small-Cell" 29387235 "Predictive relevance of miR-34a, miR-224 and miR-342 in patients with advanced squamous cell carcinoma of the lung undergoing palliative chemotherapy" -other hsa-mir-23a Neoplasms [unspecific] 29387410 the miR-23a/24-2/27a cluster may be a useful marker for predicting cancer prognosis and tumor progression -other hsa-mir-24-2 Neoplasms [unspecific] 29387410 the miR-23a/24-2/27a cluster may be a useful marker for predicting cancer prognosis and tumor progression -other hsa-mir-27a Neoplasms [unspecific] 29387410 the miR-23a/24-2/27a cluster may be a useful marker for predicting cancer prognosis and tumor progression -other hsa-mir-34a Liver Diseases [unspecific] 29391755 "After normalization of the steatosis-related circRNA by expression vector, analysis of miR-34a activity, peroxisome proliferator-activated receptor (PPAR)¦Á level, and expression of downstream genes were carried out so as to reveal its impact on the miR-34a/PPAR¦Á regulatory system" -other hsa-mir-27a Breast Neoplasms 29393459 Liraglutide inhibits the proliferation and promotes the apoptosis of MCF-7 human breast cancer cells through downregulation of microRNA-27a expression -other hsa-mir-17 Hypoxic-Ischemic Encephalopathy 29394934 IRE1¦Á inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic-ischemic brain injury in rats -other hsa-mir-17 Infertility 29402772 Ablation of the MiR-17-92 MicroRNA Cluster in Germ Cells Causes Subfertility in Female Mice -other hsa-mir-18 Infertility 29402772 Ablation of the MiR-17-92 MicroRNA Cluster in Germ Cells Causes Subfertility in Female Mice -other hsa-mir-19a Infertility 29402772 Ablation of the MiR-17-92 MicroRNA Cluster in Germ Cells Causes Subfertility in Female Mice -other hsa-mir-19b-1 Infertility 29402772 Ablation of the MiR-17-92 MicroRNA Cluster in Germ Cells Causes Subfertility in Female Mice -other hsa-mir-20a Infertility 29402772 Ablation of the MiR-17-92 MicroRNA Cluster in Germ Cells Causes Subfertility in Female Mice -other hsa-mir-92-1 Infertility 29402772 Ablation of the MiR-17-92 MicroRNA Cluster in Germ Cells Causes Subfertility in Female Mice -other hsa-mir-592 Ischemia 29402808 Effects of MicroRNA-592-5p on Hippocampal Neuron Injury Following Hypoxic-Ischemic Brain Damage in Neonatal Mice - Involvement of PGD2/DP and PTGDR. -other hsa-mir-16 Vascular Disease [unspecific] 29402872 "This revascularization is associated with a decrease in miRNA-16 expression permissive for increased VEGF protein expression, suggesting a mechanism for potential therapeutic application in vascular diseases" -other hsa-mir-370 Ovarian Neoplasms 29403287 Long noncoding RNA H19 promotes transforming growth factor-¦Â-induced epithelial-mesenchymal transition by acting as a competing endogenous RNA of miR-370-3p in ovarian cancer cells -other hsa-mir-145 Colorectal Carcinoma 29404790 the pattern of miRNA expression and its correlation with histological markers are potentially valuable to apply as diagnostic biomarkers for CRC -other hsa-mir-20a Colorectal Carcinoma 29404790 the pattern of miRNA expression and its correlation with histological markers are potentially valuable to apply as diagnostic biomarkers for CRC -other hsa-mir-21 Colorectal Carcinoma 29404790 the pattern of miRNA expression and its correlation with histological markers are potentially valuable to apply as diagnostic biomarkers for CRC -other hsa-mir-155 Allergic Contact Dermatitis 29404871 Involvement of the Negative Feedback of IL-33 Signaling in the Anti-Inflammatory Effect of Electro-acupuncture on Allergic Contact Dermatitis via Targeting MicroRNA-155 in Mast Cells -other hsa-let-7 Brain Disease [unspecific] 29408500 MicroRNA let-7c-5p improves neurological outcomes in a murine model of traumatic brain injury by suppressing neuroinflammation and regulating microglial activation -other hsa-mir-122 Hepatitis C Virus Infection 29411512 This result along with the idea about the driver function of circulating miRNAs will promote further investigations that eventually lead to the development of novel strategies to treat HCV infection-associated extrahepatic comorbidities -other hsa-mir-7 Ovarian Neoplasms 29411964 Enhanced Chemotherapeutic Efficacy of Paclitaxel Nanoparticles Co-delivered with MicroRNA-7 by Inhibiting Paclitaxel-Induced EGFR/ERK pathway Activation for Ovarian Cancer Therapy -other hsa-mir-21 Gastric Neoplasms 29422082 CBX7 regulates stem cell-like properties of gastric cancer cells via p16 and AKT-NF-¦ÊB-miR-21 pathways -other hsa-mir-181a Neuroblastoma 29426375 Triptolide inhibits proliferation and migration of human neuroblastoma SH-SY5Y cells by up-regulating microRNA-181a -other hsa-mir-409 Sarcoma [unspecific] 29430619 "A Regulatory Circuitry Between Gria2, miR-409, and miR-495 Is Affected by ALS FUS Mutation in ESC-Derived Motor Neurons." -other hsa-mir-495 Sarcoma [unspecific] 29430619 "A Regulatory Circuitry Between Gria2, miR-409, and miR-495 Is Affected by ALS FUS Mutation in ESC-Derived Motor Neurons." -other hsa-mir-449a Breast Neoplasms 29431182 Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-000911/miR-449a pathway in breast carcinogenesis -other hsa-mir-181b "Adenocarcinoma, Lung" 29434967 Celastrol suppresses the proliferation of lung adenocarcinoma cells by regulating microRNA-24 and microRNA-181b -other hsa-mir-24 "Adenocarcinoma, Lung" 29434967 Celastrol suppresses the proliferation of lung adenocarcinoma cells by regulating microRNA-24 and microRNA-181b -other hsa-mir-146a Atrial Fibrillation 29437577 MiR-146a Regulates Neutrophil Extracellular Trap Formation That Predicts Adverse Cardiovascular Events in Patients With Atrial Fibrillation -other hsa-mir-21 Ischemic Heart Disease 29444190 Bone marrow mesenchymal stem cell-derived exosomal miR-21 protects C-kit+ cardiac stem cells from oxidative injury through the PTEN/PI3K/Akt axis -other hsa-mir-223 Inflammation 29444433 MicroRNA-223 Suppresses the Canonical NF-¦ÊB Pathway in Basal Keratinocytes to Dampen Neutrophilic Inflammation -other hsa-mir-146a Atherosclerosis 29449647 "they express a remarkably high basal level of miR-146a, a microRNA known to negatively regulate the TLR pathway" -other hsa-mir-146a Osteoarthritis 29449647 "they express a remarkably high basal level of miR-147a, a microRNA known to negatively regulate the TLR pathway" -other hsa-mir-630 Ovarian Neoplasms 29452092 MicroRNA-630 inhibitor sensitizes chemoresistant ovarian cancer to chemotherapy by enhancing apoptosis. -other hsa-let-7f Asthma 29455573 A CREB-mediated increase in miRNA let-7f during prolonged ¦Â-agonist exposure: a novel mechanism of ¦Â2-adrenergic receptor down-regulation in airway smooth muscle -other hsa-mir-214 Gastric Neoplasms 29456019 Exosomes Serve as Nanoparticles to Deliver Anti-miR-214 to Reverse Chemoresistance to Cisplatin in Gastric Cancer -other hsa-mir-21 Cardiovascular Diseases [unspecific] 29456377 the stability of both DIM and pre-miR-21 was found to be inversely correlated to each other in binding condition -other hsa-mir-21 Vascular Disease [unspecific] 29456377 the stability of both DIM and pre-miR-22 was found to be inversely correlated to each other in binding condition -other hsa-mir-21 Colorectal Carcinoma 29456985 Evaluation of miR-21 Inhibition and its Impact on Cancer Susceptibility Candidate 2 Long Noncoding RNA in Colorectal Cancer Cell Line -other hsa-mir-145 Gastrointestinal Neoplasms 29459716 "miR-145, which blocked EGFR endocytosis, prolonged EGFR membrane signaling and altered responsiveness of colon cancer cells to EGFR-targeting drugs" -other hsa-mir-17 Gastrointestinal Neoplasms 29459716 "The regulation of EGF receptor (EGFR) endocytosis by two predicted miRNAs, namely miR-17 and miR-145, was confirmed experimentally" -other hsa-mir-125b Spinal Cord Injuries 29461585 MicroRNA-125b promotes the regeneration and repair of spinal cord injury through regulation of JAK/STAT pathway -other hsa-mir-143 Endometriosis 29463003 "miR-17-5p/20a, miR-200, miR-199a, miR-143, and miR-145 were explored for their pivotal role in the aetiopathogenesis of endometriosis" -other hsa-mir-145 Endometriosis 29463003 "miR-17-5p/20a, miR-200, miR-199a, miR-143, and miR-145 were explored for their pivotal role in the aetiopathogenesis of endometriosis" -other hsa-mir-17 Endometriosis 29463003 "miR-17-5p/20a, miR-200, miR-199a, miR-143, and miR-145 were explored for their pivotal role in the aetiopathogenesis of endometriosis" -other hsa-mir-199a Endometriosis 29463003 "miR-17-5p/20a, miR-200, miR-199a, miR-143, and miR-145 were explored for their pivotal role in the aetiopathogenesis of endometriosis" -other hsa-mir-200 Endometriosis 29463003 "miR-17-5p/20a, miR-200, miR-199a, miR-143, and miR-145 were explored for their pivotal role in the aetiopathogenesis of endometriosis" -other hsa-mir-20a Endometriosis 29463003 "miR-17-5p/20a, miR-200, miR-199a, miR-143, and miR-145 were explored for their pivotal role in the aetiopathogenesis of endometriosis" -other hsa-mir-145 Pancreatic Neoplasms 29464032 Selective packaging of miRNAs into EVs led to enrichment of stromal specific miR-145 in EVs secreted by TAS cells -other hsa-mir-155 Atherosclerosis 29465752 both the atherosclerosis inducer ox-LDL and atheroprotective factor KLF2 regulated inflammation-associated microRNA-155 (miR-155) expression in human umbilical vein endothelial cells (HUVECs) -other hsa-mir-675 Neuroblastoma 29465760 "Angelica sinensis polysaccharide inhibits proliferation, migration, and invasion by downregulating microRNA-675 in human neuroblastoma cell line SH-SY5Y." -other hsa-mir-132 Infection [unspecific] 29467760 MicroRNA Regulation of Host Immune Responses following Fungal Exposure -other hsa-mir-146a Infection [unspecific] 29467760 MicroRNA Regulation of Host Immune Responses following Fungal Exposure -other hsa-mir-126 Status Epilepticus 29468563 the analysis of miRNA levels in serum could provide clinicians with a tool to evaluate disease evolution and the efficacy of ¦Á-T therapy in SE -other hsa-mir-590 Gastric Neoplasms 29473240 Loss of PPM1F expression predicts tumour recurrence and is negatively regulated by miR-590-3p in gastric cancer. -other hsa-mir-371a Germ Cell Tumor 29474847 Serum miRNA Predicts Viable Disease after Chemotherapy in Patients with Testicular Nonseminoma Germ Cell Tumor. -other hsa-mir-182 Sensorineural Hearing Loss 29476110 "A mouse model of miR-96, miR-182 and miR-183 misexpression implicates miRNAs in cochlear cell fate and homeostasis" -other hsa-mir-183 Sensorineural Hearing Loss 29476110 "A mouse model of miR-96, miR-182 and miR-183 misexpression implicates miRNAs in cochlear cell fate and homeostasis" -other hsa-mir-96 Sensorineural Hearing Loss 29476110 "A mouse model of miR-96, miR-182 and miR-183 misexpression implicates miRNAs in cochlear cell fate and homeostasis" -other hsa-mir-126 Diabetes Mellitus 29477147 "While both miRs have differential functions on endothelial VCAM expression, miR-19a and miR-126 cooperate to exhibit anti-thrombotic properties via regulating vascular TF expression" -other hsa-mir-19a Diabetes Mellitus 29477147 "While both miRs have differential functions on endothelial VCAM expression, miR-19a and miR-126 cooperate to exhibit anti-thrombotic properties via regulating vascular TF expression" -other hsa-mir-30c Cardiovascular Diseases [unspecific] 29483230 Cocaine Exposure Increases Blood Pressure and Aortic Stiffness via the miR-30c-5p-Malic Enzyme 1-Reactive Oxygen Species Pathway. -other hsa-mir-210 Myocardial Infarction 29484401 MicroRNA-210 promotes angiogenesis in acute myocardial infarction -other hsa-mir-16 Acute Lung Injury 29484411 miR-16 inhibits hyperoxia-induced cell apoptosis in human alveolar epithelial cells -other hsa-mir-146a Non-Syndromic Orofacial Clefts 29484780 A functional polymorphism in the pre-miR-146a gene is associated with the risk of nonsyndromic orofacial cleft. -other hsa-mir-206 Amyotrophic Lateral Sclerosis 29486297 Muscle microRNA signatures as biomarkers of disease progression in amyotrophic lateral sclerosis. -other hsa-mir-31 "Adenocarcinoma, Pancreatic Ductal" 29486633 The AT-rich interactive domain 1A expression level in the cells was increased following microRNA-31 (miR-31) inhibitor transfection -other hsa-mir-122 Chronic Hepatitis C 29486652 Functional sequestration of microRNA-122 from Hepatitis C Virus by circular RNA sponges -other hsa-mir-133b Diabetic Retinopathy 29488353 Effects of microRNA-133b on retinal vascular endothelial cell proliferation and apoptosis through angiotensinogen-mediated angiotensin II- extracellular signal-regulated kinase 1/2 signalling pathway in rats with diabetic retinopathy. -other hsa-mir-9 "Adenocarcinoma, Lung" 29492899 differences in cell response (both miR-9 and proliferation) to dexamethasone in na?ve and desialylated cells may point to non-genomic dexamethasone effects -other hsa-mir-20a Colon Neoplasms 29492958 Targeting liver sinusoidal endothelial cells with miR-20a-loaded nanoparticles reduces murine colon cancer metastasis to the liver. -other hsa-mir-124 Stroke 29494665 MicroRNA-124-loaded nanoparticles increase survival and neuronal differentiation of neural stem cells in vitro but do not contribute to stroke outcome in vivo -other hsa-mir-9 Human Immunodeficiency Virus Infection 29497921 Exosomal miR-9 Released from HIV Tat Stimulated Astrocytes Mediates Microglial Migration -other hsa-mir-21 Lung Neoplasms 29501572 "Involvement of HIF-1¦Á-regulated miR-21, acting via the Akt/NF-¦ÊB pathway, in malignant transformation of HBE cells induced by cigarette smoke extract." -other hsa-mir-21 Atherosclerosis 29503197 Local Delivery of miR-21 Stabilizes Fibrous Caps in Vulnerable Atherosclerotic Lesions -other hsa-mir-144 "Carcinoma, Thyroid, Anaplastic" 29504819 Effects of miR-144 on the sensitivity of human anaplastic thyroid carcinoma cells to cisplatin by autophagy regulation. -other hsa-mir-126 "Leukemia, Myelogenous, Chronic, BCR-ABL Positive" 29505034 Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia -other hsa-mir-1 Myocardial Ischemic-Reperfusion Injury 29505745 Cardioprotective effect of paeonol against epirubicin-induced heart injury via regulating miR-1 and PI3K/AKT pathway -other hsa-mir-137 "Diabetes Mellitus, Gestational" 29505767 High glucose induces dysfunction of human umbilical vein endothelial cells by upregulating miR-137 in gestational diabetes mellitus. -other hsa-mir-208b Hypertension 29506053 "miR-26b, miR-208b and miR-499 show a distinct in profile in hypertensive patients with HFpEF that is related with functional capacity" -other hsa-mir-26b Hypertension 29506053 "miR-26b, miR-208b and miR-499 show a distinct in profile in hypertensive patients with HFpEF that is related with functional capacity" -other hsa-mir-499 Hypertension 29506053 "miR-26b, miR-208b and miR-499 show a distinct in profile in hypertensive patients with HFpEF that is related with functional capacity" -other hsa-mir-208a Myocardial Infarction 29506703 Droplet digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction -other hsa-mir-21 Arteriosclerosis Obliterans 29506703 Droplet digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction -other hsa-mir-21 Ischemia-Reperfusion Injury 29506703 Droplet digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction -other hsa-mir-21 Myocardial Infarction 29506703 Droplet digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction -other hsa-mir-499 Myocardial Infarction 29506703 Droplet digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction -other hsa-mir-384 Diabetic Encephalopathy 29511445 Control of macrophage autophagy by miR-384-5p in the development of diabetic encephalopathy. -other hsa-mir-191 "Carcinoma, Breast" 29511965 levels of miR-191-5p significantly increased during the six-month intervention -other hsa-mir-21 Colorectal Adenocarcinoma 29512659 An amplification-free electrochemical detection of exosomal miRNA-21 in serum samples -other hsa-mir-155 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 29517281 YB-1 promotes laryngeal squamous cell carcinoma progression by inducing miR-155 expression via c-Myb. -other hsa-mir-196a "Carcinoma, Hepatocellular" 29518473 Gene expression network regulated by DNA methylation and microRNA during microcystin-leucine arginine induced malignant transformation in human hepatocyte L02 cells. -other hsa-mir-221 "Carcinoma, Hepatocellular" 29518473 Gene expression network regulated by DNA methylation and microRNA during microcystin-leucine arginine induced malignant transformation in human hepatocyte L02 cells. -other hsa-mir-26a "Carcinoma, Hepatocellular" 29518473 Gene expression network regulated by DNA methylation and microRNA during microcystin-leucine arginine induced malignant transformation in human hepatocyte L02 cells. -other hsa-mir-320a "Carcinoma, Hepatocellular" 29518473 Gene expression network regulated by DNA methylation and microRNA during microcystin-leucine arginine induced malignant transformation in human hepatocyte L02 cells. -other hsa-mir-331 "Carcinoma, Hepatocellular" 29518473 Gene expression network regulated by DNA methylation and microRNA during microcystin-leucine arginine induced malignant transformation in human hepatocyte L02 cells. -other hsa-mir-145 Glioblastoma 29521593 Inhibition of glioblastoma cell invasion by hsa-miR-145-5p and hsa-miR-31-5p co-overexpression in human mesenchymal stem cells -other hsa-mir-31 Glioblastoma 29521593 Inhibition of glioblastoma cell invasion by hsa-miR-145-5p and hsa-miR-31-6p co-overexpression in human mesenchymal stem cells -other hsa-mir-204 Melanoma 29523154 "miR-204 represents a relevant mechanism in melanoma, with potential prognostic value and its loss seems to act in the CDKN2A pathway, in cooperation with NRAS" -other hsa-mir-124 Stroke 29524052 "this network-based approach to delineate miRNA, TF, and gene interactions might promote the development of effective therapeutics against ischemic stroke" -other hsa-mir-155 Stroke 29527155 the functions of the miRNA miR-155 and the effect of its in vivo inhibition on brain recovery following experimental cerebral ischemia -other hsa-mir-122 Hepatitis C Virus Infection 29528577 microRNA-122 is a potential marker of progression of hepatocytes injury in patients infected with HCV but not a reliable marker for diagnosis of HCC -other hsa-mir-27a "Adenocarcinoma, Cervical" 29531222 miR-27a inhibits cervical adenocarcinoma progression by downregulating the TGF-¦ÂRI signaling pathway. -other hsa-mir-200c Breast Neoplasms 29532351 Bioluminescence Imaging for Monitoring miR-200c Expression in Breast Cancer Cells and its Effects on Epithelial-Mesenchymal Transition Progress in Living Animals -other hsa-mir-130a Osteoarthritis 29532889 MicroRNA-130a regulates chondrocyte proliferation and alleviates osteoarthritis through PTEN/PI3K/Akt signaling pathway -other hsa-let-7i Diabetic Polyneuropathy 29533535 "let-7i is widely expressed in sensory neurons, supports their growth and is depleted in experimental DPN" -other hsa-mir-122 "Carcinoma, Hepatocellular" 29534065 "We identified a miRNA panel comprised of four miRNAs (miR-192, miR-122, miR-181b and miR-125a-5p) that may serve as a molecular tool for characterization of the CD134+ cells associated with different stages of hepatocarinogensis" -other hsa-mir-125a "Carcinoma, Hepatocellular" 29534065 "We identified a miRNA panel comprised of four miRNAs (miR-192, miR-122, miR-181b and miR-125a-5p) that may serve as a molecular tool for characterization of the CD136+ cells associated with different stages of hepatocarinogensis" -other hsa-mir-181b "Carcinoma, Hepatocellular" 29534065 "We identified a miRNA panel comprised of four miRNAs (miR-192, miR-122, miR-181b and miR-125a-5p) that may serve as a molecular tool for characterization of the CD135+ cells associated with different stages of hepatocarinogensis" -other hsa-mir-192 "Carcinoma, Hepatocellular" 29534065 "We identified a miRNA panel comprised of four miRNAs (miR-192, miR-122, miR-181b and miR-125a-5p) that may serve as a molecular tool for characterization of the CD133+ cells associated with different stages of hepatocarinogensis" -other hsa-mir-425 Respiratory System Disease 29535266 Prader-Willi region non-protein coding RNA 1 suppressed gastric cancer growth as a competing endogenous RNA of miR-425-5p. -other hsa-mir-181a Inflammation 29535629 we provide the first evidence for the negative regulation of miR-181a in LPS-induced inflammation via the suppression of ROS generation and TLR4-NF-¦ÊB pathway -other hsa-mir-21 "Carcinoma, Hepatocellular" 29538313 our analysis identified novel miR-21 targets that are likely to play a causal role in hepatocarcinogenesis -other hsa-mir-122 Hepatitis E Virus Infection 29540601 Positive regulation of hepatitis E virus replication by microRNA-122 -other hsa-mir-21 Chronic Obstructive Pulmonary Disease 29543496 MicroRNA-21 aggravates chronic obstructive pulmonary disease by promoting autophagy -other hsa-mir-29b Colon Neoplasms 29545333 A miR-29b Byproduct Sequence Exhibits Potent Tumor-Suppressive Activities via Inhibition of NF-¦ÊB Signaling in KRAS-Mutant Colon Cancer Cells -other hsa-mir-106b Brain Neoplasms 29547527 The Oncogenic Relevance of miR-17-92 Cluster and Its Paralogous miR-106b-25 and miR-106a-363 Clusters in Brain Tumors -other hsa-mir-17 Brain Neoplasms 29547527 The Oncogenic Relevance of miR-17-92 Cluster and Its Paralogous miR-106b-25 and miR-106a-363 Clusters in Brain Tumors -other hsa-mir-18 Brain Neoplasms 29547527 The Oncogenic Relevance of miR-17-92 Cluster and Its Paralogous miR-106b-25 and miR-106a-363 Clusters in Brain Tumors -other hsa-mir-19a Brain Neoplasms 29547527 The Oncogenic Relevance of miR-17-92 Cluster and Its Paralogous miR-106b-25 and miR-106a-363 Clusters in Brain Tumors -other hsa-mir-19b-1 Brain Neoplasms 29547527 The Oncogenic Relevance of miR-17-92 Cluster and Its Paralogous miR-106b-25 and miR-106a-363 Clusters in Brain Tumors -other hsa-mir-20a Brain Neoplasms 29547527 The Oncogenic Relevance of miR-17-92 Cluster and Its Paralogous miR-106b-25 and miR-106a-363 Clusters in Brain Tumors -other hsa-mir-25 Brain Neoplasms 29547527 The Oncogenic Relevance of miR-17-92 Cluster and Its Paralogous miR-106b-25 and miR-106a-363 Clusters in Brain Tumors -other hsa-mir-92-1 Brain Neoplasms 29547527 The Oncogenic Relevance of miR-17-92 Cluster and Its Paralogous miR-106b-25 and miR-106a-363 Clusters in Brain Tumors -other hsa-mir-93 Brain Neoplasms 29547527 The Oncogenic Relevance of miR-17-92 Cluster and Its Paralogous miR-106b-25 and miR-106a-363 Clusters in Brain Tumors -other hsa-mir-122 Hepatitis C Virus Infection 29549787 Identification of nucleotides in the 5'UTR and amino acids substitutions that are essential for the infectivity of 5'UTR-NS5A recombinant of hepatitis C virus genotype 1b (strain Con1). -other hsa-mir-106b "Squamous Cell Carcinoma, Esophageal" 29552108 miR-106b promotes cell invasion and metastasis via PTEN mediated EMT in ESCC -other hsa-mir-375 "Carcinoma, Hepatocellular" 29555460 "miR-375/Sf-LCC NPs can deliver sorafenib and miR-375 into HCC cells and tumor tissues, increase drug retention time in tumor, significantly inhibit autophagy and produce enhanced anti-tumor effect" -other hsa-mir-34a Myocardial Infarction 29559958 "miR-34a, a microRNA known to promote pro-apoptotic role in myocardial infarction during degenerative process of cardiac injuries thus indicating intrinsic differences in the nature of the mechanisms underlying the heart failure triggered by Trypanosoma cruzi infection." -other hsa-mir-155 Infectious Bursal Disease Virus 29564226 gga-miR-155 plays a critical role in cell response to IBDV infection -other hsa-mir-132 "Carcinoma, Breast" 29567542 MicroRNA-132 and microRNA-212 mediate doxorubicin resistance by down-regulating the PTEN-AKT/NF-¦ÊB signaling pathway in breast cancer. -other hsa-mir-212 "Carcinoma, Breast" 29567542 MicroRNA-132 and microRNA-212 mediate doxorubicin resistance by down-regulating the PTEN-AKT/NF-¦ÊB signaling pathway in breast cancer. -other hsa-let-7a Gastric Neoplasms 29567564 Simultaneous detection of gastric cancer-involved miR-106a and let-7a through a dual-signal-marked electrochemical nanobiosensor. -other hsa-mir-106a Gastric Neoplasms 29567564 Simultaneous detection of gastric cancer-involved miR-106a and let-7a through a dual-signal-marked electrochemical nanobiosensor. -other hsa-mir-135b Colorectal Carcinoma 29569786 The aggressive function of IL-13/STAT6/ZEB1 axis in colorectal cancer was impaired by propofol through miR-361 and miR-135b -other hsa-mir-361 Colorectal Carcinoma 29569786 The aggressive function of IL-13/STAT6/ZEB1 axis in colorectal cancer was impaired by propofol through miR-361 and miR-135b -other hsa-mir-192 "Squamous Cell Carcinoma, Lung" 29571988 MiR-192 and miR-662 enhance chemoresistance and invasiveness of squamous cell lung carcinoma -other hsa-mir-662 "Squamous Cell Carcinoma, Lung" 29571988 MiR-192 and miR-662 enhance chemoresistance and invasiveness of squamous cell lung carcinoma -other hsa-mir-92a Neoplasms [unspecific] 29574928 Our results show that miR-92a possesses a cell-type dependent function -other hsa-mir-19a "Carcinoma, Gallbladder" 29575299 The PLGF/c-MYC/miR-19a axis promotes metastasis and stemness in gallbladder cancer. -other hsa-mir-146a Osteoarthritis 29575548 miR-146a may be used to counter both aging-associated OA and mechanical injury-/inflammation-induced PTOA -other hsa-mir-155 Rheumatoid Arthritis 29575671 Rituximab may cause increased hepatitis C virus viremia in rheumatoid arthritis patients through declining exosomal microRNA-155 -other hsa-mir-34a "Carcinoma, Gastric" 29577459 "abnormal glycolysis was relieved by ASIV via regulation of the expressions of LDHA, p53, TIGAR, MCT1, MCT4, HIF-1¦Á, CD147, and miRNA-34a" -other hsa-mir-34a Toxic Encephalopathy 29578002 microRNA-34a could improve anesthesia-induced cognitive dysfunction by suppressing cell apoptosis and recovering the expression of genes associated with the MAPK/ERK signaling pathway -other hsa-mir-34a Hypoxia 29581146 Inhibition of miR-34a-5p alleviates hypoxia-reoxygenation injury by enhancing autophagy in steatotic hepatocytes -other hsa-mir-23a Renal Fibrosis 29582582 miRNA-23a/27a attenuates muscle atrophy and renal fibrosis through muscle-kidney crosstalk. -other hsa-mir-27a Renal Fibrosis 29582582 miRNA-23a/27a attenuates muscle atrophy and renal fibrosis through muscle-kidney crosstalk. -other hsa-mir-214 Heart Failure 29584819 "ROCR acted as a microRNA-214 sponge to release PTEN, which blocked activation of the PI3 kinase/Akt pathway to inhibit cardiomyocyte proliferation and ROCR may be a novel therapeutic target for preventing and treating heart failure" -other hsa-let-7i Colon Neoplasms 29588449 "Available gene expression data allowed us to associate miR-30b expression with axon guidance and let-7i expression with cell adhesion, migration, and motility" -other hsa-mir-30b Colon Neoplasms 29588449 "Available gene expression data allowed us to associate miR-30b expression with axon guidance and let-7i expression with cell adhesion, migration, and motility" -other hsa-mir-10b Breast Ductal Carcinoma 29599829 "miR-10b-positive expression was correlated with the expression of ER-¦Á, Her-2 and the molecular subtypes of early invasive ductal carcinoma of the breast" -other hsa-let-7a Monocytic Leukemia 29599918 FC-99 ameliorates sepsis-induced liver dysfunction by modulating monocyte/macrophage differentiation via Let-7a related monocytes apoptosis. -other hsa-mir-146 Inflammation 29601548 "the NF-¦ÊB-miR-146 and NF-¦ÊB-miR-155 networks fine-tune the activity, intensity, and duration of inflammation, while the NF-¦ÊB-miR-21 and NF-¦ÊB-miR-181b-1 amplifying loops link inflammation to cancer" -other hsa-mir-155 Inflammation 29601548 "the NF-¦ÊB-miR-146 and NF-¦ÊB-miR-155 networks fine-tune the activity, intensity, and duration of inflammation, while the NF-¦ÊB-miR-21 and NF-¦ÊB-miR-181b-1 amplifying loops link inflammation to cancer" -other hsa-mir-181b Neoplasms [unspecific] 29601548 "the NF-¦ÊB-miR-146 and NF-¦ÊB-miR-155 networks fine-tune the activity, intensity, and duration of inflammation, while the NF-¦ÊB-miR-21 and NF-¦ÊB-miR-181b-2 amplifying loops link inflammation to cancer" -other hsa-mir-21 Neoplasms [unspecific] 29601548 "the NF-¦ÊB-miR-146 and NF-¦ÊB-miR-155 networks fine-tune the activity, intensity, and duration of inflammation, while the NF-¦ÊB-miR-21 and NF-¦ÊB-miR-181b-3 amplifying loops link inflammation to cancer" -other hsa-mir-141 Neoplasms [unspecific] 29602800 The microRNA-200 family coordinately regulates cell adhesion and proliferation in hair morphogenesis. -other hsa-mir-200a Neoplasms [unspecific] 29602800 The microRNA-200 family coordinately regulates cell adhesion and proliferation in hair morphogenesis. -other hsa-mir-200b Neoplasms [unspecific] 29602800 The microRNA-200 family coordinately regulates cell adhesion and proliferation in hair morphogenesis. -other hsa-mir-200c Neoplasms [unspecific] 29602800 The microRNA-200 family coordinately regulates cell adhesion and proliferation in hair morphogenesis. -other hsa-mir-429 Neoplasms [unspecific] 29602800 The microRNA-200 family coordinately regulates cell adhesion and proliferation in hair morphogenesis. -other hsa-mir-566 "Carcinoma, Renal Cell" 29604591 miR-566 functions as an oncogene and a potential biomarker for prognosis in renal cell carcinoma. -other hsa-mir-31 Wound Healing 29605672 "these findings identify miR-31 as an important cell-autonomous mediator during the transition from inflammation to re-epithelialization phases of wound healing, suggesting a therapeutic potential for miR-31 in skin injury repair" -other hsa-mir-181a Vascular Disease [unspecific] 29608244 microRNA-181a inhibits ocular neovascularization by interfering with vascular endothelial growth factor expression. -other hsa-mir-146a Alzheimer Disease 29615954 Microbiome-Mediated Upregulation of MicroRNA-146a in Sporadic Alzheimer's Disease -other hsa-mir-150 Age-Related Macular Degeneration 29618664 miR-150 as pathogenic in AMD and provide potentially novel molecular insights into diseases of aging -other hsa-mir-642a "Carcinoma, Breast" 29620153 we examined the effects of synthetic miR-762 and miR-642a-3p inhibitors on SAHA-induced downregulation of Her2/neu and SAHA-induced apoptosis and PARP cleavage in BT474 cells -other hsa-mir-762 "Carcinoma, Breast" 29620153 we examined the effects of synthetic miR-762 and miR-642a-3p inhibitors on SAHA-induced downregulation of Her2/neu and SAHA-induced apoptosis and PARP cleavage in BT474 cells -other hsa-mir-210 Mitochondrial Metabolism Disease 29621777 Loading MiR-210 in Endothelial Progenitor Cells Derived Exosomes Boosts Their Beneficial Effects on Hypoxia/Reoxygeneation-Injured Human Endothelial Cells via Protecting Mitochondrial Function -other hsa-mir-20a Glioblastoma 29625108 "The findings of the current study demonstrate presence of the IDH1 R132H mutation in primary human glioblastoma cell lines with upregulated HIF-1¦Á expression, downregulating c-MYC activity and resulting in a consequential decrease in miR-20a, which is responsible for cell proliferation and resistance to standard temozolomide treatment" -other hsa-mir-20a Glioma 29625108 Oncogenic MicroRNA-20a is downregulated by the HIF-1¦Á/c-MYC pathway in IDH1 R132H-mutant glioma -other hsa-mir-378 Fatty Liver [unspecific] 29625129 A negative feedback loop between microRNA-378 and Nrf1 promotes the development of hepatosteatosis in mice treated with a high fat diet. -other hsa-mir-155 "Carcinoma, Cervical" 29627439 MiR-155-5p inhibits PDK1 and promotes autophagy via the mTOR pathway in cervical cancer. -other hsa-mir-21 Alzheimer Disease 29635890 "miR-21 can exert protective roles in AD, which might be dependent on PDCD4/PI3K/AKT/GSK-3¦Â signaling pathway in vitro" -other hsa-mir-21 Neuroblastoma 29635890 MiR-21 attenuates apoptosis-triggered by amyloid-¦Â via modulating PDCD4/PI3K/AKT/GSK-3¦Â pathway in SH-SY5Y cells -other hsa-mir-17 Feingold Syndrome 29636449 Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models. -other hsa-mir-18 Feingold Syndrome 29636449 Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models. -other hsa-mir-19a Feingold Syndrome 29636449 Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models. -other hsa-mir-19b-1 Feingold Syndrome 29636449 Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models. -other hsa-mir-20a Feingold Syndrome 29636449 Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models. -other hsa-mir-92-1 Feingold Syndrome 29636449 Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models. -other hsa-mir-1 Neoplasms [unspecific] 29642568 "A single sub-lethal dose of irradiation has been shown to result in compensatory up-regulation of the myocardial connexin-43 (Cx43), activation of the protein kinase C (PKC) signaling along with the decline of microRNA (miR)-1 and an increase of miR-21 levels in the left ventricle (LV)" -other hsa-mir-21 Neoplasms [unspecific] 29642568 Irradiation-Induced Cardiac Connexin-43 and miR-21 Responses Are Hampered by Treatment with Atorvastatin and Aspirin -other hsa-let-7 Neoplasms [unspecific] 29644076 These observations emphasize the central importance of IGF signaling pathways in the mediation of intragenomic conflicts over embryonic growth and identify possible targets for therapeutic interventions in cancer -other hsa-mir-2113 Proliferative Diabetic Retinopathy 29654764 Rg1 inhibits high glucose-induced mesenchymal activation and fibrosis via regulating miR-2113/RP11-982M15.8/Zeb1 pathway. -other hsa-mir-200c Colorectal Carcinoma 29656186 DCLK1 plays an important role in colorectal cancer tumorgenesis through the regulation of miR-200c. -other hsa-mir-146a "Leukemia, Myeloid, Acute" 29657293 miR-146 (146a and 146b) and miR-155 are among the first and most studied miRs for their multiple roles in the control of the innate and adaptive immune processes and for their deregulation and oncogenic role in some tumors -other hsa-mir-146b "Leukemia, Myeloid, Acute" 29657293 miR-146 (146a and 146b) and miR-155 are among the first and most studied miRs for their multiple roles in the control of the innate and adaptive immune processes and for their deregulation and oncogenic role in some tumors -other hsa-let-7 Ovarian Neoplasms 29658612 let-7d-3p is associated with apoptosis and response to neoadjuvant chemotherapy in ovarian cancer -other hsa-mir-21 Atherosclerosis 29659130 its involvement in the complex development of atherosclerosis has yet to be ascertained -other hsa-mir-21 Cardiovascular Diseases [unspecific] 29659130 "MicroRNA-21 (miR-21) is a short, non-coding RNA that has been implicated in cardiovascular diseases including proliferative vascular disease and ischaemic heart disease" -other hsa-mir-21 Vascular Disease [unspecific] 29659130 "MicroRNA-21 (miR-21) is a short, non-coding RNA that has been implicated in cardiovascular diseases including proliferative vascular disease and ischaemic heart disease" -other hsa-mir-449a Bladder Neoplasms 29659560 Androgen Receptor Is Inactivated and Degraded in Bladder Cancer Cells by Phenyl Glucosamine via miR-449a Restoration. -other hsa-mir-214 Endometriosis 29660008 Exosomal miR-214 from endometrial stromal cells inhibits endometriosis fibrosis. -other hsa-mir-148a "Carcinoma, Pancreatic Ductal" 29660218 Molecular pathogenesis of pancreatic ductal adenocarcinoma: Impact of passenger strand of pre-miR-148a on gene regulation. -other hsa-mir-30e Cholangiocarcinoma 29662654 Extracellular vesicle-encapsulated miR-30e suppresses cholangiocarcinoma cell invasion and migration via inhibiting epithelial-mesenchymal transition -other hsa-mir-200c "Carcinoma, Breast, Triple Negative" 29666469 the new p53/miR-30a/ZEB2 axis controls tumor cell invasion and distal spreading and impinges upon miR-200c expression -other hsa-mir-10b "Carcinoma, Renal Cell, Clear-Cell" 29672315 MicroRNA-10b Promotes Apoptosis via JNK Pathway in Clear Cell Renal Cell Carcinoma -other hsa-mir-122 Chronic Hepatitis C 29672716 "miR-122 does not impact recognition of the HCV genome by innate sensors of RNA but rather protects the 5' end from the cellular pyrophosphatases, DOM3Z and DUSP11" -other hsa-mir-155 "Carcinoma, Gastric" 29675003 Role of microRNAs and Exosomes in Helicobacter pylori and Epstein-Barr Virus Associated Gastric Cancers -other hsa-mir-155 Gastric Neoplasms 29675003 Role of microRNAs and Exosomes in Helicobacter pylori and Epstein-Barr Virus Associated Gastric Cancers -other hsa-mir-590 Influenza 29677213 IFN-¦Ë and microRNAs are important modulators of the pulmonary innate immune response against influenza A (H1N2) infection in pigs -other hsa-mir-143 "Diabetes Mellitus, Type 2" 29680463 "we will summarize the involvement of miR-143 in regulating the development of T2DM and the underlying mechanisms for potential diagnosis, prevention, and treatments, including exercise intervention for T2DM by targeting miR-143" -other hsa-mir-19a Multiple Myeloma 29687521 "Signal pathways, diseases, and functions associated with the miR-19a/92a cluster and the use of berberine to modulate the expression of this cluster in multiple myeloma cells." -other hsa-mir-92a Multiple Myeloma 29687521 "Signal pathways, diseases, and functions associated with the miR-19a/92a cluster and the use of berberine to modulate the expression of this cluster in multiple myeloma cells." -other hsa-mir-199a Arteriovenous Malformations of the Brain 29689389 "Functional annotation suggested that 15 of the predicted miRNA-targeted genes were involved in vascular endothelial growth factor signaling, in which 3 critical miRNAs were involved: miR-7-5p, miR-199a-5p, and miR-200b-3p" -other hsa-mir-200b Arteriovenous Malformations of the Brain 29689389 "Functional annotation suggested that 15 of the predicted miRNA-targeted genes were involved in vascular endothelial growth factor signaling, in which 3 critical miRNAs were involved: miR-7-5p, miR-199a-5p, and miR-200b-3p" -other hsa-mir-7 Arteriovenous Malformations of the Brain 29689389 "Functional annotation suggested that 15 of the predicted miRNA-targeted genes were involved in vascular endothelial growth factor signaling, in which 3 critical miRNAs were involved: miR-7-5p, miR-199a-5p, and miR-200b-3p" -other hsa-mir-181a "Carcinoma, Renal Cell" 29693121 microRNA?181a?5p functions as an oncogene in renal cell carcinoma. -other hsa-mir-214 "Adenocarcinoma, Lung" 29693173 TWIST1 upregulates miR-214 to promote epithelial-to-mesenchymal transition and metastasis in lung adenocarcinoma. -other hsa-mir-155 Rheumatoid Arthritis 29693176 PU.1 attenuates TNF?¦Á?induced proliferation and cytokine release of rheumatoid arthritis fibroblast?like synoviocytes by regulating miR?155 activity. -other hsa-mir-604 Gastric Neoplasms 29693274 miR-604 could become a new indicator in the diagnosis of drug-resistant GC and may be used to investigate the pathogenesis of resistance in GC -other hsa-mir-339 Acute Pancreatitis 29693276 MicroRNA-339-3p alleviates inflammation and edema and suppresses pulmonary microvascular endothelial cell apoptosis in mice with severe acute pancreatitis-associated acute lung injury by regulating Anxa3 via the Akt/mTOR signaling pathway. -other hsa-mir-139 "Carcinoma, Hepatocellular" 29693285 Higher variety and quantity of microRNA-139-5p isoforms confer suppressive role in hepatocellular carcinoma. -other hsa-mir-383 Coronary Artery Disease 29693751 The anti-inflammatory effect of microRNA-383-3p interacting with IL1R2 against homocysteine-induced endothelial injury in rat coronary arteries. -other hsa-mir-196a "Carcinoma, Renal Cell, Clear-Cell" 29695508 "ANKHD1 positively drives ccRCC cell mitosis via binding to and suppressing mainly miR-29a and to a lesser degree via miR-196a/205, leading to up-regulation in proliferative genes such as CCDN1" -other hsa-mir-205 "Carcinoma, Renal Cell, Clear-Cell" 29695508 "ANKHD1 positively drives ccRCC cell mitosis via binding to and suppressing mainly miR-29a and to a lesser degree via miR-196a/205, leading to up-regulation in proliferative genes such as CCDN1" -other hsa-mir-29a "Carcinoma, Renal Cell, Clear-Cell" 29695508 "ANKHD1 positively drives ccRCC cell mitosis via binding to and suppressing mainly miR-29a and to a lesser degree via miR-196a/205, leading to up-regulation in proliferative genes such as CCDN1" -other hsa-mir-221 Infection [unspecific] 29698854 Avian leukosis virus subgroup J promotes cell proliferation and cell cycle progression through miR-221 by targeting CDKN1B. -other hsa-mir-200b "Carcinoma, Breast" 29702103 The miR-200b/200a/429 cluster prevents metastasis and induces dormancy in a murine claudin-low mammary tumor cell line. -other hsa-mir-200c "Carcinoma, Breast" 29702103 The miR-200b/200a/429 cluster prevents metastasis and induces dormancy in a murine claudin-low mammary tumor cell line. -other hsa-mir-429 "Carcinoma, Breast" 29702103 The miR-200b/200a/429 cluster prevents metastasis and induces dormancy in a murine claudin-low mammary tumor cell line. -other hsa-mir-34c Becker Muscular Dystrophy 29703249 miR-708-5p and miR-34c-5p are involved in nNOS regulation in dystrophic context. -other hsa-mir-708 Becker Muscular Dystrophy 29703249 miR-708-5p and miR-34c-5p are involved in nNOS regulation in dystrophic context. -other hsa-mir-145 Atherosclerosis 29710501 Microrna-145 accelerates the inflammatory reaction through activation of NF-¦ÊB signaling in atherosclerosis cells and mice. -other hsa-mir-29c Colorectal Carcinoma 29710520 Inhibition of miR-29c could dramatically reverse Astragaloside IV-induced B7-H3 decrease and cell growth arrest -other hsa-mir-126 "Diabetes Mellitus, Type 2" 29710530 Resveratrol improves uric acid-induced pancreatic ¦Â-cells injury and dysfunction through regulation of miR-126. -other hsa-mir-125b "Carcinoma, Lung, Non-Small-Cell" 29722542 Repolarization of Tumor-Associated Macrophages in a Genetically Engineered Nonsmall Cell Lung Cancer Model by Intraperitoneal Administration of Hyaluronic Acid-Based Nanoparticles Encapsulating MicroRNA-125b. -other hsa-mir-142 Asthma 29722559 miR-142-3p is associated with aberrant WNT signaling during airway remodeling in asthma. -other hsa-mir-222 Glioblastoma 29723631 "the microRNAs (miRNAs) miR-27a, miR-222, miR-449 was observed after exposure to curcumin" -other hsa-mir-27a Glioblastoma 29723631 "the microRNAs (miRNAs) miR-27a, miR-222, miR-449 was observed after exposure to curcumin" -other hsa-mir-449 Glioblastoma 29723631 "the microRNAs (miRNAs) miR-27a, miR-222, miR-449 was observed after exposure to curcumin" -other hsa-mir-486 Hyperlipidemia 29725814 Inhibition of miR-486 and miR-92a decreases liver and plasma cholesterol levels by modulating lipid-related genes in hyperlipidemic hamsters. -other hsa-mir-92a Hyperlipidemia 29725814 Inhibition of miR-486 and miR-92a decreases liver and plasma cholesterol levels by modulating lipid-related genes in hyperlipidemic hamsters. -other hsa-mir-1910 Colorectal Carcinoma 29729381 STAT1-mediated upregulation of lncRNA LINC00174 functions a ceRNA for miR-1910-3p to facilitate colorectal carcinoma progression through regulation of TAZ. -other hsa-mir-186 Chondrosarcoma 29730230 Resistin facilitates VEGF-C-associated lymphangiogenesis by inhibiting miR-186 in human chondrosarcoma cells. -other hsa-mir-21 "Adenocarcinoma, Lung" 29730429 Lung adenocarcinoma cell-derived exosomal miR-21 facilitates osteoclastogenesis. -other hsa-mir-199 Cystic Fibrosis 29732561 Small RNA and transcriptome sequencing reveal the role of miR-199a-3p in inflammatory processes in cystic fibrosis airways. -other hsa-mir-221 Atherosclerosis 29737876 MicroRNA-221/222 expression in atherosclerotic coronary artery plaque versus internal mammarian artery and in peripheral blood samples. -other hsa-mir-222 Atherosclerosis 29737876 MicroRNA-221/222 expression in atherosclerotic coronary artery plaque versus internal mammarian artery and in peripheral blood samples. -other hsa-mir-141 "Squamous Cell Carcinoma, Esophageal" 29738771 "MiR-141-3p is upregulated in esophageal squamous cell carcinoma and targets pleckstrin homology domain leucine-rich repeat protein phosphatase-2, a negative regulator of the PI3K/AKT pathway." -other hsa-mir-1 "Muscular Dystrophy, Facioscapulohumeral" 29741619 Small noncoding RNAs in FSHD2 muscle cells reveal both DUX4- and SMCHD1-specific signatures. -other hsa-mir-133a "Muscular Dystrophy, Facioscapulohumeral" 29741619 Small noncoding RNAs in FSHD2 muscle cells reveal both DUX4- and SMCHD1-specific signatures. -other hsa-mir-206 "Muscular Dystrophy, Facioscapulohumeral" 29741619 Small noncoding RNAs in FSHD2 muscle cells reveal both DUX4- and SMCHD1-specific signatures. -other hsa-mir-1 Ischemia-Reperfusion Injury 29741915 The role of microRNA-1 targeting of MAPK3 in myocardial ischemia-reperfusion injury in rats undergoing sevoflurane preconditioning via the PI3K/Akt pathway. -other hsa-mir-380 Neoplasms [unspecific] 29743236 "2-hydroxyglutarate (2-HG) stabilizes hypoxia-inducible factor-2¦Á, which in turn activates the expression of miR-380-5p, a characterized microRNA against p53 expression" -other hsa-mir-10a Atherosclerosis 29748186 miR-10a expression was negatively correlated to the progression of atherosclerosis in humans -other hsa-mir-345 Prostate Neoplasms 29748958 Functional roles and potential clinical application of miRNA-345-5p in prostate cancer. -other hsa-mir-25 Breast Neoplasms 29765562 A myriad of roles of miR-25 in health and disease. -other hsa-mir-27a Bronchopneumonia 29772436 Tanshinone IIA ameliorates lipopolysaccharide-induced inflammatory response in bronchial epithelium cell line BEAS-2B by down-regulating miR-27a. -other hsa-mir-199a "Carcinoma, Renal Cell, Clear-Cell" 29773428 MiR-199a-3p acts as a tumor suppressor in clear cell renal cell carcinoma. -other hsa-mir-34a Chronic Inflammation 29773953 miR-34a-mediated regulation of XIST in female cells under inflammation. -other hsa-mir-1 Myocardial Infarction 29775643 Myocardial infarction-induced hippocampal microtubule damage by cardiac originating microRNA-1 in mice. -other hsa-mir-135a Cardiac Fibrosis 29775892 MicroRNA-135a inhibits cardiac fibrosis induced by isoproterenol via TRPM7 channel. -other hsa-mir-24 Hypertrophy 29786048 Cardiac Hypertrophy is Positively Regulated by MicroRNA?24 in Rats -other hsa-mir-200b Cardiac Fibrosis 29786779 DNMT3A controls miR-200b in cardiac fibroblast autophagy and cardiac fibrosis. -other hsa-mir-30e Sepsis 29787988 MicroRNA-30e promotes hepatocyte proliferation and inhibits apoptosis in cecal ligation and puncture-induced sepsis through the JAK/STAT signaling pathway by binding to FOSL2. -other hsa-let-7b Monocytic Leukemia 29790117 Regulatory roles of miR-155 and let-7b on the expression of inflammation-related genes in THP-1 cells: effects of fatty acids. -other hsa-mir-155 Monocytic Leukemia 29790117 Regulatory roles of miR-155 and let-7b on the expression of inflammation-related genes in THP-1 cells: effects of fatty acids. -other hsa-mir-146a Neoplasms [unspecific] 29800683 "We will specifically focus on three miRNAs that have been shown to regulate different aspects of T cell biology in both physiological and pathological conditions, namely miR-155, miR-146a and miR-181a" -other hsa-mir-155 Neoplasms [unspecific] 29800683 "We will specifically focus on three miRNAs that have been shown to regulate different aspects of T cell biology in both physiological and pathological conditions, namely miR-155, miR-146a and miR-181a" -other hsa-mir-181a Neoplasms [unspecific] 29800683 "We will specifically focus on three miRNAs that have been shown to regulate different aspects of T cell biology in both physiological and pathological conditions, namely miR-155, miR-146a and miR-181a" -other hsa-mir-15a Prostate Neoplasms 29803177 miR-15a/miR-16 cluster inhibits invasion of prostate cancer cells by suppressing TGF-¦Â signaling pathway. -other hsa-mir-16 Prostate Neoplasms 29803177 miR-15a/miR-16 cluster inhibits invasion of prostate cancer cells by suppressing TGF-¦Â signaling pathway. -other hsa-mir-204 "Carcinoma, Renal Cell, Clear-Cell" 29805586 hsa-miR-204 and hsa-miR-218 may be involved in the pathogenesis of ccRCC -other hsa-mir-218 "Carcinoma, Renal Cell, Clear-Cell" 29805586 hsa-miR-204 and hsa-miR-218 may be involved in the pathogenesis of ccRCC -other hsa-mir-106a Colorectal Carcinoma 29805629 MicroRNA-106a inhibits cell proliferation and induces apoptosis in colorectal cancer cells. -other hsa-mir-127 Glioma 29805677 Tudor-staphylococcal nuclease regulates the expression and biological function of alkylglycerone phosphate synthase via nuclear factor-¦ÊB and microRNA-127 in human glioma U87MG cells. -other hsa-mir-181b "Stroke, Ischemic" 29807144 Neuroprotective effects of isosteviol sodium through increasing CYLD by the downregulation of miRNA-181b. -other hsa-mir-21 Lung Fibrosis 29843043 Resveratrol inhibits pulmonary fibrosis by regulating miR-21 through MAPK/AP-1 pathways. -other hsa-mir-221 Retinoblastoma 29843209 Upregulated miR-221/222 promotes cell proliferation and invasion and is associated with invasive features in retinoblastoma. -other hsa-mir-222 Retinoblastoma 29843209 Upregulated miR-221/222 promotes cell proliferation and invasion and is associated with invasive features in retinoblastoma. -other hsa-mir-206 Rhabdomyosarcoma 29844345 "SNAIL silencing induces myogenic differentiation by upregulation of myogenic factors and muscle-specific microRNAs, such as miR-206." -other hsa-mir-143 Liver Neoplasms 29844837 The mechanism of miR-143 inducing apoptosis of liver carcinoma cells through regulation of the NF-¦ÊB pathway. -other hsa-mir-133 Acute Myocardial Infarction 29845217 "By searching the mir2disease database, four miRNAs associated with AMI were identified, including hsa-miR-21, hsa-miR-133, hsa-miR-29 and hsa-miR-30c." -other hsa-mir-21 Acute Myocardial Infarction 29845217 "By searching the mir2disease database, four miRNAs associated with AMI were identified, including hsa-miR-21, hsa-miR-133, hsa-miR-29 and hsa-miR-30c." -other hsa-mir-29 Acute Myocardial Infarction 29845217 "By searching the mir2disease database, four miRNAs associated with AMI were identified, including hsa-miR-21, hsa-miR-133, hsa-miR-29 and hsa-miR-30c." -other hsa-mir-30c Acute Myocardial Infarction 29845217 "By searching the mir2disease database, four miRNAs associated with AMI were identified, including hsa-miR-21, hsa-miR-133, hsa-miR-29 and hsa-miR-30c." -other hsa-mir-24 Aneurysmal Subarachnoid Hemorrhage 29845232 Upregulation of microRNA?24 causes vasospasm following subarachnoid hemorrhage by suppressing the expression of endothelial nitric oxide synthase. -other hsa-mir-16 Rheumatic Myocarditis 29845432 "significant downregulation of hsa-miR-16-5p, hsa-miR-223-3p and hsa-miR-92a-3p in children with rheumatic carditis" -other hsa-mir-223 Rheumatic Myocarditis 29845432 "significant downregulation of hsa-miR-16-5p, hsa-miR-223-3p and hsa-miR-92a-3p in children with rheumatic carditis" -other hsa-mir-92a Rheumatic Myocarditis 29845432 "significant downregulation of hsa-miR-16-5p, hsa-miR-223-3p and hsa-miR-92a-3p in children with rheumatic carditis" -other hsa-mir-130a "Diabetes Mellitus, Type 2" 29855803 Aerobic training improves platelet function in type 2 diabetic patients: role of microRNA-130a and GPIIb. -other hsa-mir-22 Neoplasms [unspecific] 29856481 "Triose-phosphate isomerase is a novel target of miR-22 and miR-28, with implications in tumorigenesis." -other hsa-mir-28 Neoplasms [unspecific] 29856481 "Triose-phosphate isomerase is a novel target of miR-22 and miR-28, with implications in tumorigenesis." -other hsa-mir-210 "Carcinoma, Hepatocellular" 29858059 Hepatocellular Carcinoma Cell-Secreted Exosomal MicroRNA-210 Promotes Angiogenesis In?Vitro and In?Vivo. -other hsa-mir-326 Lupus Nephritis 29858063 MicroRNA-326?Upregulates B Cell Activity and Autoantibody Production in Lupus Disease of MRL/lpr Mice. -other hsa-mir-449a "Carcinoma, Lung, Non-Small-Cell" 29858080 Targeting Nicotinamide N-Methyltransferase and miR-449a in EGFR-TKI-Resistant Non-Small-Cell Lung Cancer Cells. -other hsa-mir-122 Muscle Diseases [unspecific] 29858088 miR-24 and miR-122 Negatively Regulate the Transforming Growth Factor-¦Â/Smad Signaling Pathway in Skeletal Muscle Fibrosis. -other hsa-mir-24 Muscle Diseases [unspecific] 29858088 miR-24 and miR-122 Negatively Regulate the Transforming Growth Factor-¦Â/Smad Signaling Pathway in Skeletal Muscle Fibrosis. -other hsa-mir-132 Huntington Disease 29858092 Supplemental Treatment for Huntington's Disease with miR-132 that Is Deficient in Huntington's Disease Brain. -other hsa-mir-182 Parkinson Disease 29858093 miR-182-5p and miR-183-5p Act as GDNF Mimics in Dopaminergic Midbrain Neurons. -other hsa-mir-183 Parkinson Disease 29858093 miR-182-5p and miR-183-5p Act as GDNF Mimics in Dopaminergic Midbrain Neurons. -other hsa-mir-483 Neoplasms [unspecific] 29867024 The Glucose-Regulated MiR-483-3p Influences Key Signaling Pathways in Cancer. -other hsa-mir-101 Gastric Neoplasms 29872807 "miR-101-3p, miR-16-5p and miR-19b-3p were found to be located in the nuclei of MGC803 cells with granulated shapes" -other hsa-mir-16 Gastric Neoplasms 29872807 "miR-101-3p, miR-16-5p and miR-19b-3p were found to be located in the nuclei of MGC803 cells with granulated shapes" -other hsa-mir-19b Gastric Neoplasms 29872807 "miR-101-3p, miR-16-5p and miR-19b-3p were found to be located in the nuclei of MGC803 cells with granulated shapes" -other hsa-mir-106b Allergic Asthma 29875322 "This method identified 5 Th2-related miRs (mir27b, mir206, mir106b, mir203, and mir23b) whose antagonization led to a sharp reduction of the Th2 phenotype" -other hsa-mir-203 Allergic Asthma 29875322 "This method identified 5 Th2-related miRs (mir27b, mir206, mir106b, mir203, and mir23b) whose antagonization led to a sharp reduction of the Th2 phenotype" -other hsa-mir-206 Allergic Asthma 29875322 "This method identified 5 Th2-related miRs (mir27b, mir206, mir106b, mir203, and mir23b) whose antagonization led to a sharp reduction of the Th2 phenotype" -other hsa-mir-23b Allergic Asthma 29875322 "This method identified 5 Th2-related miRs (mir27b, mir206, mir106b, mir203, and mir23b) whose antagonization led to a sharp reduction of the Th2 phenotype" -other hsa-mir-27b Allergic Asthma 29875322 "This method identified 5 Th2-related miRs (mir27b, mir206, mir106b, mir203, and mir23b) whose antagonization led to a sharp reduction of the Th2 phenotype" -other hsa-mir-7 Glioma 29877083 Inhibition of the Proliferation and Invasion of C6 Glioma Cells by Tricin via the Upregulation of Focal-Adhesion-Kinase-Targeting MicroRNA-7. -other hsa-mir-208a Cardiac Myocyte Injury 29877301 MicroRNA-208a Correlates Apoptosis and Oxidative Stress Induced by H2O2 through Protein Tyrosine Kinase/Phosphatase Balance in Cardiomyocytes. -other hsa-mir-100 "Squamous Cell Carcinoma, Head and Neck" 29880533 "the expression of MIR100HG-embedded microRNA, miR-100, was significantly associated with overall survival in an independent cohort of HNSCC cases " -other hsa-mir-342 "Leukemia, Myeloid, Acute" 29880818 Aberrant mannosylation profile and FTX/miR-342/ALG3-axis contribute to development of drug resistance in acute myeloid leukemia. -other hsa-mir-514b Colorectal Carcinoma 29880874 The distinct role of strand-specific miR-514b-3p and miR-514b-5p in colorectal cancer metastasis. -other hsa-mir-139 Colorectal Carcinoma 29883634 miR-139 could be a potential biomarker for diagnosis of digestive system tumors especially colorectal cancer -other hsa-mir-21a Spinal Cord Injuries 29883711 MicroRNA-21a-5p promotes fibrosis in spinal fibroblasts after mechanical trauma. -other hsa-mir-145 Diabetic Retinopathy 29883722 MicroRNA-145 attenuates high glucose-induced oxidative stress and inflammation in retinal endothelial cells through regulating TLR4/NF-¦ÊB signaling. -other hsa-mir-187 "Carcinoma, Bladder" 29883941 "Oncogene miR-187-5p is associated with cellular proliferation, migration, invasion, apoptosis and an increased risk of recurrence in bladder cancer." -other hsa-mir-410 Cardiomyopathy 29884823 MicroRNA-410-5p exacerbates high-fat diet-induced cardiac remodeling in mice in an endocrine fashion. -other hsa-mir-1 Atrial Fibrillation 29885959 Increased right atrial appendage apoptosis is associated with differential regulation of candidate MicroRNAs 1 and 133A in patients who developed atrial fibrillation after cardiac surgery. -other hsa-mir-133a Atrial Fibrillation 29885959 Increased right atrial appendage apoptosis is associated with differential regulation of candidate MicroRNAs 1 and 133A in patients who developed atrial fibrillation after cardiac surgery. -other hsa-mir-31 "Colitis, Ulcerative" 29889228 "Our data suggest a role for TSLP in promoting mucosal healing and regulating inflammation in UC, whereas miR-31 can directly block this effect" -other hsa-mir-425 Myocardial Infarction 29890520 Overcoming Heparin-Associated RT-qPCR Inhibition and Normalization Issues for microRNA Quantification in Patients with Acute Myocardial Infarction. -other hsa-mir-197 "Lymphoma, Large B-Cell, Diffuse" 29890998 Clinicopathologic implication of microRNA-197 in diffuse large B cell lymphoma. -other hsa-mir-30 "Carcinoma, Breast" 29894647 MicroRNA-30 mediates cell invasion and metastasis in breast cancer. -other hsa-mir-200c Lung Neoplasms 29898461 miR-200c can be used as a highly sensitive molecular staging biomarker that will enhance nodal staging of lung cancer -other hsa-mir-210 Prostate Neoplasms 29901117 Effects of microRNA?210 on the diagnosis and treatment of prostate cancer. -other hsa-mir-122 Atrial Fibrillation 29901138 Upregulation of miR?122 is associated with cardiomyocyte apoptosis in atrial fibrillation. -other hsa-mir-381 "Carcinoma, Hepatocellular" 29904424 Expression and role of VEGFA and miR-381 in portal vein tumor thrombi in patients with hepatocellular carcinoma. -other hsa-mir-124a Kidney Diseases [unspecific] 29904949 Combination with miR-124a improves the protective action of BMSCs in rescuing injured rat podocytes from abnormal apoptosis and autophagy. -other hsa-mir-203 "Carcinoma, Hepatocellular" 29906128 MicroRNA-203 Increases Cell Radiosensitivity via Directly Targeting Bmi-1 in Hepatocellular Carcinoma. -other hsa-mir-199b Pulmonary Hypertension 29906222 "This study describes a novel microRNA signature of adaptive right ventricular hypertrophy, with particular attention to miR-199b and miR-29a" -other hsa-mir-29a Pulmonary Hypertension 29906222 "This study describes a novel microRNA signature of adaptive right ventricular hypertrophy, with particular attention to miR-199b and miR-29a" -other hsa-mir-505 Glioblastoma 29906532 Combination with TMZ and miR-505 inhibits the development of glioblastoma by regulating the WNT7B/Wnt/¦Â-catenin signaling pathway. -other hsa-mir-181a "Carcinoma, Breast" 29907248 Micro-RNA-181a suppresses progestin-promoted breast cancer cell growth. -other hsa-mir-98 Myocardial Infarction 29913449 Pre-Treatment with Melatonin Enhances Therapeutic Efficacy of Cardiac Progenitor Cells for Myocardial Infarction. -other hsa-mir-6853 "Diabetes Mellitus, Type 2" 29916530 miR?6835?3p regulates the function of pancreatic islet cells by modulating the expression of AdipoR1. -other hsa-mir-184 Osteosarcoma 29916553 Regulatory effects of microRNA?184 on osteosarcoma via the Wnt/¦Â?catenin signaling pathway. -other hsa-mir-26a Acute Cerebral Infarction 29917203 MiRNA-26a promotes angiogenesis in a rat model of cerebral infarction via PI3K/AKT and MAPK/ERK pathway. -other hsa-mir-499 Cardiovascular Diseases [unspecific] 29920798 Unlockable Nanocomplexes with Self-Accelerating Nucleic Acid Release for Effective Staged Gene Therapy of Cardiovascular Diseases. -other hsa-mir-107 "Carcinoma, Breast" 29921315 Expression of ID4 protein in breast cancer cells induces reprogramming of tumour-associated macrophages. -other hsa-mir-15b "Carcinoma, Breast" 29921315 Expression of ID4 protein in breast cancer cells induces reprogramming of tumour-associated macrophages. -other hsa-let-7g Lung Neoplasms 29923982 "Three miRNAs (let-7g-5p, miR-143-3p, and miR-374a-5p) were associated with postoperative recurrence in both microarray and TCGA data sets" -other hsa-mir-143 Lung Neoplasms 29923982 "Three miRNAs (let-7g-5p, miR-143-3p, and miR-374a-5p) were associated with postoperative recurrence in both microarray and TCGA data sets" -other hsa-mir-374a Lung Neoplasms 29923982 "Three miRNAs (let-7g-5p, miR-143-3p, and miR-374a-5p) were associated with postoperative recurrence in both microarray and TCGA data sets" -other hsa-mir-320b Acute Ischemic Stroke 29926387 Unique MicroRNAs Signature of Lymphocyte of Yang and Yin Syndromes in Acute Ischemic Stroke Patients. -other hsa-mir-93 Acute Ischemic Stroke 29926387 Unique MicroRNAs Signature of Lymphocyte of Yang and Yin Syndromes in Acute Ischemic Stroke Patients. -other hsa-mir-888 Colorectal Carcinoma 29928331 miR-888 functions as an oncogene and predicts poor prognosis in colorectal cancer. -other hsa-mir-148a "Carcinoma, Lung, Non-Small-Cell" 29928367 miR-148a may regulate a panel of tumor-associated proteins to suppress metastasis in NSCLC -other hsa-mir-130a Diabetic Peripheral Neuropathy 29932869 Exosomes derived from high-glucose-stimulated Schwann cells promote development of diabetic peripheral neuropathy. -other hsa-mir-28 Diabetic Peripheral Neuropathy 29932869 Exosomes derived from high-glucose-stimulated Schwann cells promote development of diabetic peripheral neuropathy. -other hsa-mir-31a Diabetic Peripheral Neuropathy 29932869 Exosomes derived from high-glucose-stimulated Schwann cells promote development of diabetic peripheral neuropathy. -other hsa-mir-496 "Carcinoma, Oropharyngeal" 29935424 Human papillomavirus 16 E6 modulates the expression of miR-496 in oropharyngeal cancer. -other hsa-mir-26b Ischemic Diseases [unspecific] 29937716 MicroRNA-26b Regulates the Microglial Inflammatory Response in Hypoxia/Ischemia and Affects the Development of Vascular Cognitive Impairment. -other hsa-mir-126 Fabry Disease 29937989 "miR-199a-5p, and miR-126-3p are involved in endothelial dysfunction and miR-423-5p and miR-451a in myocardial remodeling" -other hsa-mir-199a Fabry Disease 29937989 "miR-199a-5p, and miR-126-3p are involved in endothelial dysfunction and miR-423-5p and miR-451a in myocardial remodeling" -other hsa-mir-423 Fabry Disease 29937989 "miR-199a-5p, and miR-126-3p are involved in endothelial dysfunction and miR-423-5p and miR-451a in myocardial remodeling" -other hsa-mir-451a Fabry Disease 29937989 "miR-199a-5p, and miR-126-3p are involved in endothelial dysfunction and miR-423-5p and miR-451a in myocardial remodeling" -other hsa-mir-383 Colorectal Carcinoma 29938829 MicroRNA-383 acts as a tumor suppressor in colorectal cancer by modulating CREPT/RPRD1B expression. -other hsa-mir-7 "Carcinoma, Breast" 29941867 Association of microRNA-7 and its binding partner CDR1-AS with the prognosis and prediction of 1st-line tamoxifen therapy in breast cancer. -other hsa-mir-205 Ovarian Neoplasms 29943422 Tanshinone IIA induced cell apoptosis in ovarian carcinoma TOV-21G cells via direct upregulation of miR-205 -other hsa-mir-198 "Carcinoma, Lung, Non-Small-Cell" 29943841 MicroRNA-198 inhibition of HGF/c-MET signaling pathway overcomes resistance to radiotherapy and induces apoptosis in human non-small-cell lung cancer. -other hsa-mir-106a Gastric Neoplasms 29948558 Negative Regulation of Kruppel-Like Factor 4 on microRNA-106a at Upstream Transcriptional Level and the Role in Gastric Cancer Metastasis. -other hsa-mir-19 Ischemia-Reperfusion Injury 29953651 MicroRNA-19 restores vascular endothelial cell function in lower limb ischemia-reperfusion injury through the KLF10-dependent TGF-¦Â1/Smad signaling pathway in rats. -other hsa-mir-17 Gastric Neoplasms 29953965 MicroRNA-17 inhibition overcomes chemoresistance and suppresses epithelial-mesenchymal transition through a DEDD-dependent mechanism in gastric cancer. -other hsa-mir-26a "Aortic Aneurysm, Abdominal" 29956734 MicroRNA?26a protects vascular smooth muscle cells against H2O2?induced injury through activation of the PTEN/AKT/mTOR pathway. -other hsa-mir-361 Gastric Neoplasms 29960070 MiR-361-5p inhibits the mobility of gastric cancer cells through suppressing epithelial-mesenchymal transition via the Wnt/¦Â-catenin pathway. -other hsa-mir-19b Ovarian Neoplasms 29963131 MicroRNA-19b promotes the migration and invasion of ovarian cancer cells by inhibiting the PTEN/AKT signaling pathway. -other hsa-mir-202 "Carcinoma, Breast" 29963190 miR-202 acts as a potential tumor suppressor in breast cancer. -other hsa-mir-140 Porcine Reproductive and Respiratory Syndrome Virus Infection 29969475 Utilizing host endogenous microRNAs to negatively regulate the replication of porcine reproductive and respiratory syndrome virus in MARC-145 cells. -other hsa-mir-181 "Leukemia, Myeloid, Acute" 29969755 Circ-ANAPC7 is Upregulated in Acute Myeloid Leukemia and Appears to Target the MiR-181 Family. -other hsa-mir-106b "Carcinoma, Bladder" 29970902 Identification of microR-106b as a prognostic biomarker of p53-like bladder cancers by ActMiR. -other hsa-mir-155 Atherosclerosis 29977930 TRIF Regulates BIC/miR-155 via the ERK Signaling Pathway to Control the ox-LDL-Induced Macrophage Inflammatory Response. -other hsa-mir-199a "Lymphoma, Mantle-Cell" 29979193 MiR-199a mediated the dissemination of human mantle cell lymphoma by interacting with the CCR7/CCL21 pair. -other hsa-mir-142 Coronary Artery Disease 29979444 miR-142-3p and miR-17-5p might be potential targets for follow-up research in evaluating biomarkers of coronary artery disease -other hsa-mir-17 Coronary Artery Disease 29979444 miR-142-3p and miR-17-5p might be potential targets for follow-up research in evaluating biomarkers of coronary artery disease -other hsa-mir-132 Alzheimer Disease 29982852 MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways. -other hsa-mir-181 Cardiovascular Diseases [unspecific] 29985373 In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge. -other hsa-mir-135b Gastric Neoplasms 29985646 Helicobacter pylori-induced miR-135b-5p promotes cisplatin resistance in gastric cancer. -other hsa-mir-196a "Carcinoma, Pancreatic" 29986379 miR-196a Is Able to Restore the Aggressive Phenotype of Annexin A1 Knock-Out in Pancreatic Cancer Cells by CRISPR/Cas9 Genome Editing. -other hsa-mir-663 Neoplasms [unspecific] 29987196 "MiR-663, a MicroRNA Linked with Inflammation and Cancer That Is under the Influence of Resveratrol." -other hsa-mir-101 "Adenocarcinoma, Esophageal" 29987600 Two miRNA ratios (miR-4521/miR-340-5p and miR-101-3p/miR-451a) that predicted the pathological response to neoadjuvant chemoradiotherapy were found to be associated with relapse-free survival -other hsa-mir-340 "Adenocarcinoma, Esophageal" 29987600 Two miRNA ratios (miR-4521/miR-340-5p and miR-101-3p/miR-451a) that predicted the pathological response to neoadjuvant chemoradiotherapy were found to be associated with relapse-free survival -other hsa-mir-451a "Adenocarcinoma, Esophageal" 29987600 Two miRNA ratios (miR-4521/miR-340-5p and miR-101-3p/miR-451a) that predicted the pathological response to neoadjuvant chemoradiotherapy were found to be associated with relapse-free survival -other hsa-mir-4521 "Adenocarcinoma, Esophageal" 29987600 Two miRNA ratios (miR-4521/miR-340-5p and miR-101-3p/miR-451a) that predicted the pathological response to neoadjuvant chemoradiotherapy were found to be associated with relapse-free survival -other hsa-let-7b Rectum Adenocarcinoma 29988972 we identified an association between increased let-7b and worse clinical outcomes -other hsa-mir-152 "Carcinoma, Breast, Triple Negative" 29990486 Melatonin restrains angiogenic factors in triple-negative breast cancer by targeting miR-152-3p: In vivo and in vitro studies. -other hsa-mir-155 Heart Failure 29990505 Osteoglycin post-transcriptional regulation by miR-155 induces cellular architecture changes in H9c2 cardiomyoblasts. -other hsa-mir-21 "Carcinoma, Renal Cell" 29993250 Small Molecule Inhibition of MicroRNA miR-21 Rescues Chemosensitivity of Renal-Cell Carcinoma to Topotecan. -other hsa-mir-146a Amyotrophic Lateral Sclerosis 29995256 Data indicate that astrocytes in mSOD1 mice model acquire early phenotypic aberrancies and highlight downregulated miR-146a as a biomarker and drug target in ALS -other hsa-mir-149 Neoplasms [unspecific] 29999552 Regulation and functions of MicroRNA-149 in human cancers. -other hsa-mir-30a Obesity 30002134 miR-30a Remodels Subcutaneous Adipose Tissue Inflammation to Improve Insulin Sensitivity in Obesity. -other hsa-mir-4455 Gastric Neoplasms 30002604 "Vasodilator-stimulated phosphoprotein (VASP), a novel target of miR-4455, promotes gastric cancer cell proliferation, migration, and invasion, through activating the PI3K/AKT signaling pathway." -other hsa-mir-128 "Carcinoma, Breast" 30004628 TGF¦Â1 regulates HGF-induced cell migration and hepatocyte growth factor receptor MET expression via C-ets-1 and miR-128-3p in basal-like breast cancer. -other hsa-mir-200a "Carcinoma, Thyroid, Papillary" 30005075 A potential biomarker hsa-miR-200a-5p distinguishing between benign thyroid tumors with papillary hyperplasia and papillary thyroid carcinoma. -other hsa-mir-218 Amyotrophic Lateral Sclerosis 30007309 motor neuron-derived miR-218 may have a functional role in amyotrophic lateral sclerosis -other hsa-mir-218 Prostate Neoplasms 30008871 "MicroRNA-218 inhibits the migration, epithelial-mesenchymal transition and cancer stem cell properties of prostate cancer cells." -other hsa-mir-425 "Carcinoma, Renal Cell" 30008916 "Oncogenic miR-425-5p is associated with cellular migration, proliferation and apoptosis in renal cell carcinoma." -other hsa-mir-23a Gastric Neoplasms 30008935 MicroRNA-23a/27a/24-2 cluster promotes gastric cancer cell proliferation synergistically. -other hsa-mir-24-2 Gastric Neoplasms 30008935 MicroRNA-23a/27a/24-2 cluster promotes gastric cancer cell proliferation synergistically. -other hsa-mir-27a Gastric Neoplasms 30008935 MicroRNA-23a/27a/24-2 cluster promotes gastric cancer cell proliferation synergistically. -other hsa-mir-10a "Carcinoma, Breast" 30010434 "high expression of miR-134, miR-125b-5P, miRNA-30a, miR-10a-5p and miR-222 were significantly associated with short relapse-free time" -other hsa-mir-125b "Carcinoma, Breast" 30010434 "high expression of miR-134, miR-125b-5P, miRNA-30a, miR-10a-5p and miR-222 were significantly associated with short relapse-free time" -other hsa-mir-134 "Carcinoma, Breast" 30010434 "high expression of miR-134, miR-125b-5P, miRNA-30a, miR-10a-5p and miR-222 were significantly associated with short relapse-free time" -other hsa-mir-222 "Carcinoma, Breast" 30010434 "high expression of miR-134, miR-125b-5P, miRNA-30a, miR-10a-5p and miR-222 were significantly associated with short relapse-free time" -other hsa-mir-30a "Carcinoma, Breast" 30010434 "high expression of miR-134, miR-125b-5P, miRNA-30a, miR-10a-5p and miR-222 were significantly associated with short relapse-free time" -other hsa-mir-146a Periodontitis 30012943 "These results suggest that CyP may modulate the pro-inflammatory response induced by Pg-LPS, not only by blocking TLR4-MD2 complex, but also by preserving miR-146a expression" -other hsa-mir-9 Lung Neoplasms 30012957 Lamins in Lung Cancer: Biomarkers and Key Factors for Disease Progression through miR-9 Regulation -other hsa-mir-127 Ovarian Neoplasms 30013629 miR-127 was negatively associated with tumor grade -other hsa-mir-431 "Leukemia, Myeloid, Acute" 30013666 The transfection of miR-431 suppressed the migration and invasion of AML cells -other hsa-mir-122 Ischemia-Reperfusion Injury 30014282 "The Effect of Zinc Sulfate on miR-122, miR-34a, Atioxidants, Biochemical and Histopathological Parameters Following Hepatic Ischemia/Reperfusion Injury in Rats." -other hsa-mir-34a Ischemia-Reperfusion Injury 30014282 "The Effect of Zinc Sulfate on miR-122, miR-34a, Atioxidants, Biochemical and Histopathological Parameters Following Hepatic Ischemia/Reperfusion Injury in Rats." -other hsa-mir-133b Peripheral Nerve Injury 30018017 Intrathecal Injection of miR-133b-3p or miR-143-3p Prevents the Development of Persistent Cold and Mechanical Allodynia Following a Peripheral Nerve Injury in Rats. -other hsa-mir-143 Peripheral Nerve Injury 30018017 Intrathecal Injection of miR-133b-3p or miR-143-3p Prevents the Development of Persistent Cold and Mechanical Allodynia Following a Peripheral Nerve Injury in Rats. -other hsa-let-7f Thyroid Neoplasms 30018229 "Treatment with selumetinib caused a down-regulation of hsa-let-7f-5p, hsa-miR-146b-5p and hsa-miR-146b-3p in TPC1 and BCPAP cells" -other hsa-mir-146b Thyroid Neoplasms 30018229 "Treatment with selumetinib caused a down-regulation of hsa-let-7f-5p, hsa-miR-146b-5p and hsa-miR-146b-3p in TPC1 and BCPAP cells" -other hsa-let-7 "Carcinoma, Breast" 30018709 "microRNAs (miR-21, miR-155-5p and let-7) may participate in the ILF2 expression network in breast cancer" -other hsa-mir-155 "Carcinoma, Breast" 30018709 "microRNAs (miR-21, miR-155-5p and let-7) may participate in the ILF2 expression network in breast cancer" -other hsa-mir-21 "Carcinoma, Breast" 30018709 "microRNAs (miR-21, miR-155-5p and let-7) may participate in the ILF2 expression network in breast cancer" -other hsa-mir-4319 "Carcinoma, Breast, Triple Negative" 30021199 MiR-4319 Suppress the Malignancy of Triple-Negative Breast Cancer by Regulating Self-Renewal and Tumorigenesis of Stem Cells. -other hsa-mir-21 "Carcinoma, Salivary Adenoid Cystic" 30021341 Effect of simvastatin and microRNA-21 inhibitor on metastasis and progression of human salivary adenoid cystic carcinoma. -other hsa-mir-663a "Carcinoma, Renal Cell" 30021352 Oncogenic miR-663a is associated with cellular function and poor prognosis in renal cell carcinoma. -other hsa-mir-34a Sepsis 30021364 MicroRNA-34a promotes iNOS secretion from pulmonary macrophages in septic suckling rats through activating STAT3 pathway. -other hsa-mir-449a Osteoarthritis 30021388 MicroRNA-449a upregulation promotes chondrocyte extracellular matrix degradation in osteoarthritis. -other hsa-mir-7 "Carcinoma, Lung, Non-Small-Cell" 30022841 Overexpressed CDR1as functions as an oncogene to promote the tumor progression via miR-7 in non-small-cell lung cancer. -other hsa-mir-486 Lung Neoplasms 30023372 miR-486 inhibits PM2.5-induced apoptosis and oxidative stress in human lung alveolar epithelial A549 cells. -other hsa-mir-218 Chronic Obstructive Pulmonary Disease 30024625 "miR-218-5p may, therefore, play an important role in the pathogenesis of COPD" -other hsa-mir-137 Schizophrenia 30026708 Association of MIR137 With Symptom Severity and Cognitive Functioning in Belarusian Schizophrenia Patients. -other hsa-mir-10b Neoplasms [unspecific] 30028875 Potent and selective effect of the mir-10b inhibitor MN-anti-mir10b in human cancer cells of diverse primary disease origin. -other hsa-mir-1 Cardiac Myocyte Injury 30029588 "Six of them (miR-1, miR-208a-3p, miR-199a-5p, miR-21-5p, miR-146a-5p, and miR-30c-5p) were reported to be related to cardiac pathological functions" -other hsa-mir-146a Cardiac Myocyte Injury 30029588 "Six of them (miR-1, miR-208a-3p, miR-199a-5p, miR-21-5p, miR-146a-5p, and miR-30c-5p) were reported to be related to cardiac pathological functions" -other hsa-mir-199a Cardiac Myocyte Injury 30029588 "Six of them (miR-1, miR-208a-3p, miR-199a-5p, miR-21-5p, miR-146a-5p, and miR-30c-5p) were reported to be related to cardiac pathological functions" -other hsa-mir-208a Cardiac Myocyte Injury 30029588 "Six of them (miR-1, miR-208a-3p, miR-199a-5p, miR-21-5p, miR-146a-5p, and miR-30c-5p) were reported to be related to cardiac pathological functions" -other hsa-mir-21 Cardiac Myocyte Injury 30029588 "Six of them (miR-1, miR-208a-3p, miR-199a-5p, miR-21-5p, miR-146a-5p, and miR-30c-5p) were reported to be related to cardiac pathological functions" -other hsa-mir-30c Cardiac Myocyte Injury 30029588 "Six of them (miR-1, miR-208a-3p, miR-199a-5p, miR-21-5p, miR-146a-5p, and miR-30c-5p) were reported to be related to cardiac pathological functions" -other hsa-mir-124 Chronic Hepatitis B 30031388 "miRNA-15, miRNA-124, miRNA-218-5P with significant activation of Z-Score" -other hsa-mir-15 Chronic Hepatitis B 30031388 "miRNA-15, miRNA-124, miRNA-218-5P with significant activation of Z-Score" -other hsa-mir-218 Chronic Hepatitis B 30031388 "miRNA-15, miRNA-124, miRNA-218-5P with significant activation of Z-Score" -other hsa-mir-374a "Carcinoma, Bladder" 30032142 MicroRNA-374a Inhibits Aggressive Tumor Biological Behavior in Bladder Carcinoma by Suppressing Wnt/¦Â-Catenin Signaling. -other hsa-mir-16 Prostate Neoplasms 30032144 MiR-195/-16 Family Enhances Radiotherapy via T Cell Activation in the Tumor Microenvironment by Blocking the PD-L1 Immune Checkpoint. -other hsa-mir-195 Prostate Neoplasms 30032144 MiR-195/-16 Family Enhances Radiotherapy via T Cell Activation in the Tumor Microenvironment by Blocking the PD-L1 Immune Checkpoint. -other hsa-mir-141 Glioma 30034253 The miR-200 family: multiple effects on gliomas. -other hsa-mir-200a Glioma 30034253 The miR-200 family: multiple effects on gliomas. -other hsa-mir-200b Glioma 30034253 The miR-200 family: multiple effects on gliomas. -other hsa-mir-200c Glioma 30034253 The miR-200 family: multiple effects on gliomas. -other hsa-mir-429 Glioma 30034253 The miR-200 family: multiple effects on gliomas. -other hsa-mir-494 Spinal Cord Injuries 30036869 Effects of MicroRNA-494 on Astrocyte Proliferation and Synaptic Remodeling in the Spinal Cord of a Rat Model of Chronic Compressive Spinal Cord Injury by Regulating the Nogo/Ngr Signaling Pathway. -other hsa-mir-363 Ovarian Neoplasms 30037365 MiR-363 inhibits cisplatin chemoresistance of epithelial ovarian cancer by regulating snail-induced epithelial-mesenchymal transition. -other hsa-mir-17 "Lymphoma, Non-Hodgkin" 30038718 "Lymphomas clustered according to histological subtypes, driven by two miRNA clusters (the miR-29 family and the miR-17-92 cluster)" -other hsa-mir-18 "Lymphoma, Non-Hodgkin" 30038718 "Lymphomas clustered according to histological subtypes, driven by two miRNA clusters (the miR-29 family and the miR-17-92 cluster)" -other hsa-mir-19a "Lymphoma, Non-Hodgkin" 30038718 "Lymphomas clustered according to histological subtypes, driven by two miRNA clusters (the miR-29 family and the miR-17-92 cluster)" -other hsa-mir-19b-1 "Lymphoma, Non-Hodgkin" 30038718 "Lymphomas clustered according to histological subtypes, driven by two miRNA clusters (the miR-29 family and the miR-17-92 cluster)" -other hsa-mir-20a "Lymphoma, Non-Hodgkin" 30038718 "Lymphomas clustered according to histological subtypes, driven by two miRNA clusters (the miR-29 family and the miR-17-92 cluster)" -other hsa-mir-29a "Lymphoma, Non-Hodgkin" 30038718 "Lymphomas clustered according to histological subtypes, driven by two miRNA clusters (the miR-29 family and the miR-17-92 cluster)" -other hsa-mir-29b "Lymphoma, Non-Hodgkin" 30038718 "Lymphomas clustered according to histological subtypes, driven by two miRNA clusters (the miR-29 family and the miR-17-92 cluster)" -other hsa-mir-29c "Lymphoma, Non-Hodgkin" 30038718 "Lymphomas clustered according to histological subtypes, driven by two miRNA clusters (the miR-29 family and the miR-17-92 cluster)" -other hsa-mir-92-1 "Lymphoma, Non-Hodgkin" 30038718 "Lymphomas clustered according to histological subtypes, driven by two miRNA clusters (the miR-29 family and the miR-17-92 cluster)" -other hsa-mir-29c "Carcinoma, Renal Cell, Clear-Cell" 30041179 Upregulation of MIAT Regulates LOXL2 Expression by Competitively Binding MiR-29c in Clear Cell Renal Cell Carcinoma. -other hsa-mir-134 Parkinson Disease 30041414 Delivery of miRNA-Targeted Oligonucleotides in the Rat Striatum by Magnetofection with Neuromag?. -other hsa-mir-141 "Adenocarcinoma, Pancreatic Ductal" 30041660 WIPF1 antagonizes the tumor suppressive effect of miR-141/200c and is associated with poor survival in patients with PDAC. -other hsa-mir-200c "Adenocarcinoma, Pancreatic Ductal" 30041660 WIPF1 antagonizes the tumor suppressive effect of miR-141/200c and is associated with poor survival in patients with PDAC. -other hsa-mir-135a Lung Injury [unspecific] 30045018 MiR-135a Protects Vascular Endothelial Cells Against Ventilator-Induced Lung Injury by Inhibiting PHLPP2 to Activate PI3K/Akt Pathway. -other hsa-mir-21 Rheumatoid Arthritis 30045854 Maresin 1 improves the Treg/Th17 imbalance in rheumatoid arthritis through miR-21. -other hsa-mir-132 Inflammatory Bowel Diseases 30046303 "Regarding autophagy-related pathways, miR-146b, miR-221-5p, miR-132, miR-223, miR-155, and miR-21 regulate NF-¦ÊB or mTOR signaling to induce or inhibit autophagy in intestinal cells by releasing anti- or proinflammatory factors, respectively" -other hsa-mir-146b Inflammatory Bowel Diseases 30046303 "Regarding autophagy-related pathways, miR-146b, miR-221-5p, miR-132, miR-223, miR-155, and miR-21 regulate NF-¦ÊB or mTOR signaling to induce or inhibit autophagy in intestinal cells by releasing anti- or proinflammatory factors, respectively" -other hsa-mir-155 Inflammatory Bowel Diseases 30046303 "Regarding autophagy-related pathways, miR-146b, miR-221-5p, miR-132, miR-223, miR-155, and miR-21 regulate NF-¦ÊB or mTOR signaling to induce or inhibit autophagy in intestinal cells by releasing anti- or proinflammatory factors, respectively" -other hsa-mir-21 Inflammatory Bowel Diseases 30046303 "Regarding autophagy-related pathways, miR-146b, miR-221-5p, miR-132, miR-223, miR-155, and miR-21 regulate NF-¦ÊB or mTOR signaling to induce or inhibit autophagy in intestinal cells by releasing anti- or proinflammatory factors, respectively" -other hsa-mir-221 Inflammatory Bowel Diseases 30046303 "Regarding autophagy-related pathways, miR-146b, miR-221-5p, miR-132, miR-223, miR-155, and miR-21 regulate NF-¦ÊB or mTOR signaling to induce or inhibit autophagy in intestinal cells by releasing anti- or proinflammatory factors, respectively" -other hsa-mir-223 Inflammatory Bowel Diseases 30046303 "Regarding autophagy-related pathways, miR-146b, miR-221-5p, miR-132, miR-223, miR-155, and miR-21 regulate NF-¦ÊB or mTOR signaling to induce or inhibit autophagy in intestinal cells by releasing anti- or proinflammatory factors, respectively" -other hsa-mir-15a Neoplasms [unspecific] 30047999 miR-15a/16 deletion in macrophages holds a distinct biological significance from that of the microRNA deficiency in tumour cells -other hsa-mir-16 Neoplasms [unspecific] 30047999 miR-15a/16 deletion in macrophages holds a distinct biological significance from that of the microRNA deficiency in tumour cells -other hsa-mir-101 Neoplasms [unspecific] 30049386 A Nucleolar Stress-Specific p53-miR-101 Molecular Circuit Functions as an Intrinsic Tumor-Suppressor Network. -other hsa-mir-214 Hypertension 30049682 MicroRNA-214-3p in the Kidney Contributes to the Development of Hypertension. -other hsa-mir-26b Colorectal Carcinoma 30051451 miR-26b may promote the invasion and metastasis of colorectal cancer by accelerating the migration and invasion of colorectal cancer cells -other hsa-mir-190b "Carcinoma, Breast" 30055304 "Tree-based machine learning modelstrained in my analysis used hsa-miR-139 with hsa-miR-183 to classify breast tumors from normal samples, and hsa-miR4728 with hsa-miR190b to further classify these tumors into three major subtypes of breast cancer" -other hsa-mir-4728 "Carcinoma, Breast" 30055304 "Tree-based machine learning modelstrained in my analysis used hsa-miR-139 with hsa-miR-183 to classify breast tumors from normal samples, and hsa-miR4728 with hsa-miR190b to further classify these tumors into three major subtypes of breast cancer" -other hsa-mir-146a Colon Neoplasms 30056535 Fascin protein stabilization by miR-146a implicated in the process of a chronic inflammation-related colon carcinogenesis model. -other hsa-mir-122 Hepatitis C Virus Infection 30058773 Hepatitis C Virus Infection of Cultured Cells and Primary Human Hepatocytes. -other hsa-mir-145 Bicuspid Aortic Valve Disease 30059548 MiR-145 expression and rare NOTCH1 variants in bicuspid aortic valve-associated aortopathy. -other hsa-mir-192 Hepatitis B Virus Infection 30059664 HBV upregulates the expression of miR-192-5p and miR-194-5p in the host cell -other hsa-mir-194 Hepatitis B Virus Infection 30059664 HBV upregulates the expression of miR-192-5p and miR-194-5p in the host cell -other hsa-mir-218 Preeclampsia 30061037 MicroRNA-218-5p Promotes Endovascular Trophoblast Differentiation and Spiral Artery Remodeling. -other hsa-mir-205 "Carcinoma, Renal Cell, Clear-Cell" 30061948 Comparison of exosomal microRNAs secreted by 786-O clear cell renal carcinoma cells and HK-2 proximal tubule-derived cells in culture identifies microRNA-205 as a potential biomarker of clear cell renal carcinoma. -other hsa-mir-786 "Carcinoma, Renal Cell, Clear-Cell" 30061948 Comparison of exosomal microRNAs secreted by 786-O clear cell renal carcinoma cells and HK-2 proximal tubule-derived cells in culture identifies microRNA-205 as a potential biomarker of clear cell renal carcinoma. -other hsa-mir-331 "Carcinoma, Breast" 30063890 A comprehensive clinicopathological evaluation of the differential expression of microRNA-331 in breast tumors and its diagnostic significance. -other hsa-mir-21 Traumatic Brain Injury 30066160 MicroRNA-21 in the Pathogenesis of Traumatic Brain Injury. -other hsa-mir-142 "Leukemia, Lymphoblastic, Acute" 30066657 "We successfully identified two microRNAs, hsa-miR-142-3p and hsa-miR-17-5p, which are computationally predicted to closely relate to glucocorticoid resistance" -other hsa-mir-17 "Leukemia, Lymphoblastic, Acute" 30066657 "We successfully identified two microRNAs, hsa-miR-142-3p and hsa-miR-17-5p, which are computationally predicted to closely relate to glucocorticoid resistance" -other hsa-mir-205 Prostate Neoplasms 30066866 Ultrasound?targeted microbubble destruction?mediated miR?205 enhances cisplatin cytotoxicity in prostate cancer cells. -other hsa-mir-320a Neoplasms [unspecific] 30066913 "Transcriptional activation of miR-320a by ATF2, ELK1 and YY1 induces cancer cell apoptosis under ionizing radiation conditions." -other hsa-mir-124 Gastric Neoplasms 30068360 The targets of circHIPK3-miR-124/miR-29b axes involved in the progression of GC -other hsa-mir-29b Gastric Neoplasms 30068360 The targets of circHIPK3-miR-124/miR-29b axes involved in the progression of GC -other hsa-mir-146a Osteoarthritis 30071609 the reduced expression of miR-146a was found to be coupled to reduced type II collagen (COL2) in OA cartilage -other hsa-mir-24 Mesothelioma 30072395 A Polysome-Based microRNA Screen Identifies miR-24-3p as a Novel Promigratory miRNA in Mesothelioma. -other hsa-mir-146b Vascular Disease [unspecific] 30073586 Loss of miR-146b-3p Inhibits Perivascular Adipocyte Browning with Cold Exposure During Aging. -other hsa-mir-302b "Carcinoma, Bladder" 30075175 MiR-302b regulates cell functions and acts as a potential biomarker to predict recurrence in bladder cancer. -other hsa-mir-17 Leukemia 30076175 Transcriptional activation of the miR-17-92 cluster is involved in the growth-promoting effects of MYB in human Ph-positive leukemia cells. -other hsa-mir-18 Leukemia 30076175 Transcriptional activation of the miR-17-92 cluster is involved in the growth-promoting effects of MYB in human Ph-positive leukemia cells. -other hsa-mir-19a Leukemia 30076175 Transcriptional activation of the miR-17-92 cluster is involved in the growth-promoting effects of MYB in human Ph-positive leukemia cells. -other hsa-mir-19b-1 Leukemia 30076175 Transcriptional activation of the miR-17-92 cluster is involved in the growth-promoting effects of MYB in human Ph-positive leukemia cells. -other hsa-mir-20a Leukemia 30076175 Transcriptional activation of the miR-17-92 cluster is involved in the growth-promoting effects of MYB in human Ph-positive leukemia cells. -other hsa-mir-92-1 Leukemia 30076175 Transcriptional activation of the miR-17-92 cluster is involved in the growth-promoting effects of MYB in human Ph-positive leukemia cells. -other hsa-mir-214 Muscle Diseases [unspecific] 30076721 MiR-214 is an important regulator of the musculoskeletal metabolism and disease. -other hsa-mir-142 Colitis 30076847 "administration of tetracyclines led to increased mucosal protection, associated with up-regulated expression of CCL2, miR-142 and miR-375" -other hsa-mir-375 Colitis 30076847 "administration of tetracyclines led to increased mucosal protection, associated with up-regulated expression of CCL2, miR-142 and miR-375" -other hsa-mir-548 Subacute Sclerosing Panencephalitis 30077763 "IL28B, IL29 and micro-RNA 548 in subacute sclerosing panencephalitis as a rare disease." -other hsa-mir-195 Preeclampsia 30078346 Regulatory effect of miR-195 in the placental dysfunction of preeclampsia. -other hsa-mir-142 Rheumatoid Arthritis 30081592 "Experimental and bioinformatics analyses revealed 8 miRNAs (miR-22, miR-27a, miR-96, miR-142, miR-223, miR-296, miR-298, and miR-451) and their target genes in functional pathways important for RA pathogenesis" -other hsa-mir-22 Rheumatoid Arthritis 30081592 "Experimental and bioinformatics analyses revealed 8 miRNAs (miR-22, miR-27a, miR-96, miR-142, miR-223, miR-296, miR-298, and miR-451) and their target genes in functional pathways important for RA pathogenesis" -other hsa-mir-223 Rheumatoid Arthritis 30081592 "Experimental and bioinformatics analyses revealed 8 miRNAs (miR-22, miR-27a, miR-96, miR-142, miR-223, miR-296, miR-298, and miR-451) and their target genes in functional pathways important for RA pathogenesis" -other hsa-mir-27a Rheumatoid Arthritis 30081592 "Experimental and bioinformatics analyses revealed 8 miRNAs (miR-22, miR-27a, miR-96, miR-142, miR-223, miR-296, miR-298, and miR-451) and their target genes in functional pathways important for RA pathogenesis" -other hsa-mir-296 Rheumatoid Arthritis 30081592 "Experimental and bioinformatics analyses revealed 8 miRNAs (miR-22, miR-27a, miR-96, miR-142, miR-223, miR-296, miR-298, and miR-451) and their target genes in functional pathways important for RA pathogenesis" -other hsa-mir-298 Rheumatoid Arthritis 30081592 "Experimental and bioinformatics analyses revealed 8 miRNAs (miR-22, miR-27a, miR-96, miR-142, miR-223, miR-296, miR-298, and miR-451) and their target genes in functional pathways important for RA pathogenesis" -other hsa-mir-451 Rheumatoid Arthritis 30081592 "Experimental and bioinformatics analyses revealed 8 miRNAs (miR-22, miR-27a, miR-96, miR-142, miR-223, miR-296, miR-298, and miR-451) and their target genes in functional pathways important for RA pathogenesis" -other hsa-mir-96 Rheumatoid Arthritis 30081592 "Experimental and bioinformatics analyses revealed 8 miRNAs (miR-22, miR-27a, miR-96, miR-142, miR-223, miR-296, miR-298, and miR-451) and their target genes in functional pathways important for RA pathogenesis" -other hsa-mir-145 "Adenocarcinoma, Lung" 30082847 Dual strands of the miR-145 duplex (miR-145-5p and miR-145-3p) regulate oncogenes in lung adenocarcinoma pathogenesis. -other hsa-mir-388 Pemphigus 30083474 Usefulness of miRNA-338-3p in the diagnosis of pemphigus and its correlation with disease severity. -other hsa-mir-144 Myocardial Infarction 30084039 Intravenous miR-144 reduces left ventricular remodeling after myocardial infarction. -other hsa-mir-199a "Carcinoma, Breast, Triple Negative" 30086965 "Design, development and evaluation of microRNA-199a-5p detecting electrochemical nanobiosensor with diagnostic application in Triple Negative Breast Cancer." -other hsa-mir-373 Hepatitis C Virus Infection 30089699 Association between MicroRNA-373 and Long Noncoding RNA NORAD in Hepatitis C Virus-Infected Hepatocytes Impairs Wee1 Expression for Growth Promotion. -other hsa-mir-17 Intervertebral Disc Degeneration 30089772 whereas circRNA_104670 and miRNA-17-3p inhibition mice had a higher IDD grade compared with circRNA_104670 inhibition mice -other hsa-mir-203 "Carcinoma, Breast" 30091053 Lack of effective translational regulation of PLD expression and exosome biogenesis in triple-negative breast cancer cells. -other hsa-mir-142 "Carcinoma, Breast" 30091683 miR-142-3p attenuates breast cancer stem cell characteristics and decreases radioresistance in vitro. -other hsa-mir-17 Liver Diseases [unspecific] 30092337 Bone marrow mesenchymal stromal cells attenuate liver allograft rejection may via upregulation PD-L1 expression through downregulation of miR-17-5p. -other hsa-mir-15a Premature Ovarian Failure 30092342 Induction of miR-15a expression by tripterygium glycosides caused premature ovarian failure by suppressing the Hippo-YAP/TAZ signaling effector Lats1. -other hsa-mir-1 Viral Myocarditis 30097120 Astragalus Root dry extract restores connexin43 expression by targeting miR-1 in viral myocarditis. -other hsa-mir-885 "Carcinoma, Salivary Adenoid Cystic" 30098429 Comprehensive and in-depth analysis of microRNA and mRNA expression profile in salivary adenoid cystic carcinoma. -other hsa-mir-9 Myocardial Infarction 30101604 Inhibition of MicroRNA-9-5p Protects Against Cardiac Remodeling Following Myocardial Infarction in Mice. -other hsa-mir-324 Colorectal Carcinoma 30103475 4-Acetyl-Antroquinonol B Suppresses SOD2-Enhanced Cancer Stem Cell-Like Phenotypes and Chemoresistance of Colorectal Cancer Cells by Inducing hsa-miR-324 re-Expression. -other hsa-mir-675 "Squamous Cell Carcinoma, Esophageal" 30106155 MicroRNA?675?3p promotes esophageal squamous cell cancer cell migration and invasion. -other hsa-mir-221 Parkinson Disease 30107296 The Parkinson's disease gene product DJ-1 modulates miR-221 to promote neuronal survival against oxidative stress. -other hsa-mir-449a "Carcinoma, Hepatocellular" 30108016 MicroRNA-449a suppresses hepatocellular carcinoma cell growth via G1 phase arrest and the HGF/MET c-Met pathway. -other hsa-mir-144 Lung Neoplasms 30108506 Lico A Causes ER Stress and Apoptosis via Up-Regulating miR-144-3p in Human Lung Cancer Cell Line H292. -other hsa-mir-15a Neoplasms [unspecific] 30110127 "TEC treated with HLSC-EVs significantly enhanced expression of miR-15a, miR-181b, miR-320c and miR-874 associated with the down-regulation of FGF1 and PLAU" -other hsa-mir-181b Neoplasms [unspecific] 30110127 "TEC treated with HLSC-EVs significantly enhanced expression of miR-15a, miR-181b, miR-320c and miR-874 associated with the down-regulation of FGF1 and PLAU" -other hsa-mir-320c Neoplasms [unspecific] 30110127 "TEC treated with HLSC-EVs significantly enhanced expression of miR-15a, miR-181b, miR-320c and miR-874 associated with the down-regulation of FGF1 and PLAU" -other hsa-mir-874 Neoplasms [unspecific] 30110127 "TEC treated with HLSC-EVs significantly enhanced expression of miR-15a, miR-181b, miR-320c and miR-874 associated with the down-regulation of FGF1 and PLAU" -other hsa-mir-199a Autism Spectrum Disorder 30111726 Alterations in the MicroRNA of the Blood of Autism Spectrum Disorder Patients: Effects on Epigenetic Regulation and Potential Biomarkers. -other hsa-mir-16 Gastric Neoplasms 30112563 "The miR-16-5p, which has binding sites with hsa_circ_0008106 and hsa_circ_0060456, has been confirmed to be involved in the development of gastric cancer" -other hsa-mir-21 Neoplasms [unspecific] 30113161 we used an alternative target (miR-21) and FRET pair for direct and absolute quantification of miR-21 in RNA extracts from human cancer and normal cell lines -other hsa-mir-199a Hypertension 30116316 MicroRNA-199a-5p aggravates primary hypertension by damaging vascular endothelial cells through inhibition of autophagy and promotion of apoptosis. -other hsa-mir-1826 "Carcinoma, Hepatocellular" 30116730 "we identified 7 DV-only miRNAs (hsa-miR-1826, hsa-miR-191, hsa-miR-194-star, hsa-miR-222, hsa-miR-502-3p, hsa-miR-93, and hsa-miR-99b) using the proposed method, one (hsa-miR-1826) of which has not yet been reported to be related to HCC in the literature" -other hsa-mir-191 "Carcinoma, Hepatocellular" 30116730 "we identified 7 DV-only miRNAs (hsa-miR-1826, hsa-miR-191, hsa-miR-194-star, hsa-miR-222, hsa-miR-502-3p, hsa-miR-93, and hsa-miR-99b) using the proposed method, one (hsa-miR-1826) of which has not yet been reported to be related to HCC in the literature" -other hsa-mir-194 "Carcinoma, Hepatocellular" 30116730 "we identified 7 DV-only miRNAs (hsa-miR-1826, hsa-miR-191, hsa-miR-194-star, hsa-miR-222, hsa-miR-502-3p, hsa-miR-93, and hsa-miR-99b) using the proposed method, one (hsa-miR-1826) of which has not yet been reported to be related to HCC in the literature" -other hsa-mir-222 "Carcinoma, Hepatocellular" 30116730 "we identified 7 DV-only miRNAs (hsa-miR-1826, hsa-miR-191, hsa-miR-194-star, hsa-miR-222, hsa-miR-502-3p, hsa-miR-93, and hsa-miR-99b) using the proposed method, one (hsa-miR-1826) of which has not yet been reported to be related to HCC in the literature" -other hsa-mir-502 "Carcinoma, Hepatocellular" 30116730 "we identified 7 DV-only miRNAs (hsa-miR-1826, hsa-miR-191, hsa-miR-194-star, hsa-miR-222, hsa-miR-502-3p, hsa-miR-93, and hsa-miR-99b) using the proposed method, one (hsa-miR-1826) of which has not yet been reported to be related to HCC in the literature" -other hsa-mir-93 "Carcinoma, Hepatocellular" 30116730 "we identified 7 DV-only miRNAs (hsa-miR-1826, hsa-miR-191, hsa-miR-194-star, hsa-miR-222, hsa-miR-502-3p, hsa-miR-93, and hsa-miR-99b) using the proposed method, one (hsa-miR-1826) of which has not yet been reported to be related to HCC in the literature" -other hsa-mir-99b "Carcinoma, Hepatocellular" 30116730 "we identified 7 DV-only miRNAs (hsa-miR-1826, hsa-miR-191, hsa-miR-194-star, hsa-miR-222, hsa-miR-502-3p, hsa-miR-93, and hsa-miR-99b) using the proposed method, one (hsa-miR-1826) of which has not yet been reported to be related to HCC in the literature" -other hsa-mir-21 Osteoporosis 30116953 The pivotal role of microRNA-21 in osteoclastogenesis inhibition by anthracycline glycoside aloin. -other hsa-mir-1 Heart Failure 30117672 Lycium barbarum polysaccharides restore adverse structural remodelling and cardiac contractile dysfunction induced by overexpression of microRNA-1. -other hsa-mir-92a Wound Healing 30118158 A synthetic microRNA-92a inhibitor (MRG-110) accelerates angiogenesis and wound healing in diabetic and nondiabetic wounds. -other hsa-mir-192 Mild Cognitive Impairment 30118321 Up-regulated miR-192-5p expression rescues cognitive impairment and restores neural function in mice with depression via the Fbln2-mediated TGF-¦Â1 signaling pathway. -other hsa-mir-144 "Adenocarcinoma, Lung" 30121641 IL-1¦Â-Mediated Up-Regulation of WT1D via miR-144-3p and Their Synergistic Effect with NF-¦ÊB/COX-2/HIF-1¦Á Pathway on Cell Proliferation in LUAD. -other hsa-mir-26b Glioma 30124166 the TFAP2C and hsa-miR-26b-5p might play important roles in the development and progression mechanisms of DIPG -other hsa-mir-146a Lichen Planus 30125971 Forkhead box p3 controls progression of oral lichen planus by regulating microRNA-146a. -other hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 30127862 MicroRNA-21: A promising biomarker for the prognosis and diagnosis of non-small cell lung cancer. -other hsa-mir-182 Amyotrophic Lateral Sclerosis 30128653 Memory Decline and Its Reversal in Aging and Neurodegeneration Involve miR-183/96/182 Biogenesis. -other hsa-mir-183 Amyotrophic Lateral Sclerosis 30128653 Memory Decline and Its Reversal in Aging and Neurodegeneration Involve miR-183/96/182 Biogenesis. -other hsa-mir-96 Amyotrophic Lateral Sclerosis 30128653 Memory Decline and Its Reversal in Aging and Neurodegeneration Involve miR-183/96/182 Biogenesis. -other hsa-mir-31 Cutaneous Lupus Erythematosus 30130620 MicroRNA Expression Profiling Identifies miR-31 and miR-485-3p as Regulators in the Pathogenesis of Discoid Cutaneous Lupus. -other hsa-mir-485 Cutaneous Lupus Erythematosus 30130620 MicroRNA Expression Profiling Identifies miR-31 and miR-485-3p as Regulators in the Pathogenesis of Discoid Cutaneous Lupus. -other hsa-mir-299 "Diabetes Mellitus, Type 2" 30131392 Glucolipotoxicity-Inhibited miR-299-5p Regulates Pancreatic ¦Â-Cell Function and Survival. -other hsa-mir-181 Chronic Kidney Disease 30132347 Electrically stimulated acupuncture increases renal blood flow through exosomes-carried miR-181. -other hsa-mir-132 "Carcinoma, Cervical" 30132864 HPV16 E7-induced upregulation of KDM2A promotes cervical cancer progression by regulating miR-132-radixin pathway. -other hsa-mir-199 Hepatitis C Virus Infection 30133717 "miR-23b and miR-106 might be a useful biomarker for chronic hepatitis C (CHC). MiR-27a, miR-93, and miR-199 might have a potential role in the progression of liver diseases" -other hsa-mir-27a Hepatitis C Virus Infection 30133717 "miR-23b and miR-106 might be a useful biomarker for chronic hepatitis C (CHC). MiR-27a, miR-93, and miR-199 might have a potential role in the progression of liver diseases" -other hsa-mir-93 Hepatitis C Virus Infection 30133717 "miR-23b and miR-106 might be a useful biomarker for chronic hepatitis C (CHC). MiR-27a, miR-93, and miR-199 might have a potential role in the progression of liver diseases" -other hsa-mir-145 Prostate Neoplasms 30136305 MiR-145 affected the circular RNA expression in prostate cancer LNCaP cells. -other hsa-mir-92a Acute Lung Injury 30138892 MicroRNA-92a antagonism attenuates lipopolysaccharide (LPS)-induced pulmonary inflammation and injury in mice through suppressing the PTEN/AKT/NF-¦ÊB signaling pathway. -other hsa-mir-195 Wound Healing 30141361 Negative-Pressure Wound Therapy Promotes Wound Healing by Enhancing Angiogenesis Through Suppression of NLRX1 via miR-195 Upregulation. -other hsa-mir-1908 Autoimmune Diseases [unspecific] 30143393 Evidence for a potential role of miR-1908-5p and miR-3614-5p in autoimmune disease risk using integrative bioinformatics. -other hsa-mir-3614 Autoimmune Diseases [unspecific] 30143393 Evidence for a potential role of miR-1908-5p and miR-3614-5p in autoimmune disease risk using integrative bioinformatics. -other hsa-mir-200a Hypertrophy 30144391 miR-200a-5p augments cardiomyocyte hypertrophy induced by glucose metabolism disorder via the regulation of selenoproteins. -other hsa-mir-205 Prostate Neoplasms 30149628 miRNA-205 Nanoformulation Sensitizes Prostate Cancer Cells to Chemotherapy. -other hsa-mir-375 "Diabetes Mellitus, Type 1" 30150203 Several types of miRNAs are playing important roles in type 1 diabetes mellitus including miR-375 and miR-375 with intolerance to glucose and decreased beta cells account due to impaired proliferation -other hsa-mir-320a Chronic Pain 30150364 A Functional riboSNitch in the 3' Untranslated Region of FKBP5 Alters MicroRNA-320a Binding Efficiency and Mediates Vulnerability to Chronic Post-Traumatic Pain. -other hsa-mir-155 Melanoma 30150674 Inhibition of miR-155 and miR-210 activity by transfection of miRNA inhibitors into HMEX reversed the exosome-induced metabolic reprogramming of HADF -other hsa-mir-210 Melanoma 30150674 Inhibition of miR-155 and miR-210 activity by transfection of miRNA inhibitors into HMEX reversed the exosome-induced metabolic reprogramming of HADF -other hsa-mir-139 "Carcinoma, Lung, Non-Small-Cell" 30153566 BMP4?Upregulation Is Associated with Acquired Drug Resistance and Fatty Acid Metabolism in EGFR-Mutant Non-Small-Cell Lung Cancer Cells. -other hsa-mir-16 "Carcinoma, Breast" 30154547 "Different signatures of miR-16, miR-30b and miR-93 in exosomes from breast cancer and DCIS patients." -other hsa-mir-30b "Carcinoma, Breast" 30154547 "Different signatures of miR-16, miR-30b and miR-93 in exosomes from breast cancer and DCIS patients." -other hsa-mir-93 "Carcinoma, Breast" 30154547 "Different signatures of miR-16, miR-30b and miR-93 in exosomes from breast cancer and DCIS patients." -other hsa-mir-124 Bone Disease [unspecific] 30155647 miR-124-3p is a chronic regulator of gene expression after brain injury. -other hsa-mir-570 Chronic Obstructive Pulmonary Disease 30156909 MicroRNA-570 is a novel regulator of cellular senescence and inflammaging. -other hsa-mir-214 Colorectal Carcinoma 30157478 Down-Regulation of MicroRNA-214 Contributed to the Enhanced Mitochondrial Transcription Factor A and Inhibited Proliferation of Colorectal Cancer Cells. -other hsa-mir-410 Lung Fibrosis 30157485 Prodigiosin Alleviates Pulmonary Fibrosis Through Inhibiting miRNA-410 and TGF-¦Â1/ADAMTS-1 Signaling Pathway. -other hsa-mir-218 Rheumatoid Arthritis 30157923 Osteogenic differentiation of fibroblast-like synovial cells in rheumatoid arthritis is induced by microRNA-218 through a ROBO/Slit pathway. -other hsa-mir-182 "Diabetes Mellitus, Type 2" 30160993 Intestinal bile acid sequestration improves glucose control by stimulating hepatic miR-182-5p in type 2 diabetes. -other hsa-mir-10b Neoplasms [unspecific] 30166612 "we further propose that miR-10b expression levels, due to the newly described ""hijacking"" effect, may be used as a biomarker to select patients for linifanib treatment" -other hsa-mir-187 Retinal Vascular Disease 30170060 Down-regulated miR-187 promotes oxidative stress-induced retinal cell apoptosis through P2X7 receptor. -other hsa-mir-17 Gastric Neoplasms 30170406 miR-17-92 cluster is connected with disease progression and oxaliplatin/capecitabine chemotherapy efficacy in advanced gastric cancer patients: A preliminary study. -other hsa-mir-18 Gastric Neoplasms 30170406 miR-17-92 cluster is connected with disease progression and oxaliplatin/capecitabine chemotherapy efficacy in advanced gastric cancer patients: A preliminary study. -other hsa-mir-19a Gastric Neoplasms 30170406 miR-17-92 cluster is connected with disease progression and oxaliplatin/capecitabine chemotherapy efficacy in advanced gastric cancer patients: A preliminary study. -other hsa-mir-19b-1 Gastric Neoplasms 30170406 miR-17-92 cluster is connected with disease progression and oxaliplatin/capecitabine chemotherapy efficacy in advanced gastric cancer patients: A preliminary study. -other hsa-mir-20a Gastric Neoplasms 30170406 miR-17-92 cluster is connected with disease progression and oxaliplatin/capecitabine chemotherapy efficacy in advanced gastric cancer patients: A preliminary study. -other hsa-mir-92-1 Gastric Neoplasms 30170406 miR-17-92 cluster is connected with disease progression and oxaliplatin/capecitabine chemotherapy efficacy in advanced gastric cancer patients: A preliminary study. -other hsa-mir-372 Colorectal Carcinoma 30171794 miR-372 and miR-373 enhance the stemness of colorectal cancer cells by repressing differentiation signaling pathways. -other hsa-mir-373 Colorectal Carcinoma 30171794 miR-372 and miR-373 enhance the stemness of colorectal cancer cells by repressing differentiation signaling pathways. -other hsa-mir-30c-2 "Carcinoma, Breast" 30182731 Circular RNA hsa_circ_0072995 promotes breast cancer cell migration and invasion through sponge for miR-30c-2-3p. -other hsa-mir-497 "Carcinoma, Renal Cell, Clear-Cell" 30183478 MicroRNA-497-5p down-regulation increases PD-L1 expression in clear cell renal cell carcinoma. -other hsa-mir-27a Gastric Neoplasms 30184548 Exosomal miR-27a Derived from Gastric Cancer Cells Regulates the Transformation of Fibroblasts into Cancer-Associated Fibroblasts. -other hsa-mir-3607 "Carcinoma, Hepatocellular" 30186744 "mir-424, miR-93 and miR-3607 are three hub DEmiRNAs of the HCC-specific DEmiRNA-DEmRNA interaction network." -other hsa-mir-424 "Carcinoma, Hepatocellular" 30186744 "mir-424, miR-93 and miR-3607 are three hub DEmiRNAs of the HCC-specific DEmiRNA-DEmRNA interaction network." -other hsa-mir-93 "Carcinoma, Hepatocellular" 30186744 "mir-424, miR-93 and miR-3607 are three hub DEmiRNAs of the HCC-specific DEmiRNA-DEmRNA interaction network." -other hsa-mir-17 Gastric Neoplasms 30186751 "MicroRNA-17 as a promising diagnostic biomarker of gastric cancer: An investigation combining TCGA, GEO, meta-analysis, and bioinformatics." -other hsa-mir-106b Recurrent Spontaneous Abortion 30187472 Altered T-cell subpopulations in recurrent pregnancy loss patients with cellular immune abnormalities. -other hsa-mir-25 Recurrent Spontaneous Abortion 30187472 Altered T-cell subpopulations in recurrent pregnancy loss patients with cellular immune abnormalities. -other hsa-mir-93 Recurrent Spontaneous Abortion 30187472 Altered T-cell subpopulations in recurrent pregnancy loss patients with cellular immune abnormalities. -other hsa-mir-520a Hepatitis B Virus Infection 30191752 MicroRNA-520a suppresses HBV replication in HepG2.2.15 cells by inactivating AKT. -other hsa-mir-21 Colorectal Carcinoma 30191984 Fusobacterium nucleatum and colorectal cancer: A mechanistic overview. -other hsa-mir-199a Coronary Artery Disease 30192743 MicroRNA 199a Is Downregulated in Patients After Coronary Artery Bypass Graft Surgery and Is Associated with Increased Levels of Sirtuin 1 (SIRT 1) Protein and Major Adverse Cardiovascular Events at 3-Year Follow-Up. -other hsa-mir-215 "Carcinoma, Breast" 30194145 Pax-5 Inhibits Breast Cancer Proliferation Through MiR-215 Up-regulation. -other hsa-mir-17 Prostate Neoplasms 30194146 "we identified a panel of 5-miRNA (miR-17-3p, miR-27a-3p, miR-200a-3p, miR-375, and miR-376b-3p) with a risk score strongly associated with metastasis" -other hsa-mir-200a Prostate Neoplasms 30194146 "we identified a panel of 5-miRNA (miR-17-3p, miR-27a-3p, miR-200a-3p, miR-375, and miR-376b-3p) with a risk score strongly associated with metastasis" -other hsa-mir-27a Prostate Neoplasms 30194146 "we identified a panel of 5-miRNA (miR-17-3p, miR-27a-3p, miR-200a-3p, miR-375, and miR-376b-3p) with a risk score strongly associated with metastasis" -other hsa-mir-375 Prostate Neoplasms 30194146 "we identified a panel of 5-miRNA (miR-17-3p, miR-27a-3p, miR-200a-3p, miR-375, and miR-376b-3p) with a risk score strongly associated with metastasis" -other hsa-mir-376b Prostate Neoplasms 30194146 "we identified a panel of 5-miRNA (miR-17-3p, miR-27a-3p, miR-200a-3p, miR-375, and miR-376b-3p) with a risk score strongly associated with metastasis" -other hsa-mir-155 "Squamous Cell Carcinoma, Oral" 30194167 Potential Oncogenic Role and Prognostic Implication of MicroRNA-155-5p in Oral Squamous Cell Carcinoma. -other hsa-mir-96 "Adenocarcinoma, Prostate" 30195637 "The lncRNAs MESTIT1, PCA3, and UCA1; mRNAs CYP19A1 and TDRD1; as well as miR-96 might affect the pathogenesis of PRAD" -other hsa-mir-1271 Colorectal Carcinoma 30195762 "sequester miR-135a, miR-143, miR-214, and miR-1271, protecting ANLN, BIRC5, IPO7, KIF2A, and KIF23 from microRNA (miRNA)-induced degradation" -other hsa-mir-135a Colorectal Carcinoma 30195762 "sequester miR-135a, miR-143, miR-214, and miR-1271, protecting ANLN, BIRC5, IPO7, KIF2A, and KIF23 from microRNA (miRNA)-induced degradation" -other hsa-mir-143 Colorectal Carcinoma 30195762 "sequester miR-135a, miR-143, miR-214, and miR-1271, protecting ANLN, BIRC5, IPO7, KIF2A, and KIF23 from microRNA (miRNA)-induced degradation" -other hsa-mir-214 Colorectal Carcinoma 30195762 "sequester miR-135a, miR-143, miR-214, and miR-1271, protecting ANLN, BIRC5, IPO7, KIF2A, and KIF23 from microRNA (miRNA)-induced degradation" -other hsa-mir-501 Gastric Neoplasms 30195794 miR-501 might be a potential target for doxorubicin resistance and gastric cancer therapy -other hsa-mir-126 Johne Disease 30197143 "A model was developed using a combination of 4 miRNA (miR-1976, miR-873-3p, miR-520f-3p, and miR-126-3p), which distinguished moderate and severely infected animals from noninfected animal" -other hsa-mir-1976 Johne Disease 30197143 "A model was developed using a combination of 4 miRNA (miR-1976, miR-873-3p, miR-520f-3p, and miR-126-3p), which distinguished moderate and severely infected animals from noninfected animal" -other hsa-mir-520f Johne Disease 30197143 "A model was developed using a combination of 4 miRNA (miR-1976, miR-873-3p, miR-520f-3p, and miR-126-3p), which distinguished moderate and severely infected animals from noninfected animal" -other hsa-mir-873 Johne Disease 30197143 "A model was developed using a combination of 4 miRNA (miR-1976, miR-873-3p, miR-520f-3p, and miR-126-3p), which distinguished moderate and severely infected animals from noninfected animal" -other hsa-mir-193b Melanoma 30197759 "miR-193b and miR-30c-1* inhibit, whereas miR-576-5p enhances melanoma cell invasion in vitro." -other hsa-mir-30c-1 Melanoma 30197759 "miR-193b and miR-30c-1* inhibit, whereas miR-576-5p enhances melanoma cell invasion in vitro." -other hsa-mir-576 Melanoma 30197759 "miR-193b and miR-30c-1* inhibit, whereas miR-576-5p enhances melanoma cell invasion in vitro." -other hsa-mir-143 Intracranial Aneurysm 30201338 The miR-143/145 cluster reverses the regulation effect of KLF5 in smooth muscle cells with proliferation and contractility in intracranial aneurysm. -other hsa-mir-145 Intracranial Aneurysm 30201338 The miR-143/145 cluster reverses the regulation effect of KLF5 in smooth muscle cells with proliferation and contractility in intracranial aneurysm. -other hsa-mir-9 "Carcinoma, Renal Cell" 30201928 miR-9-5p in Nephrectomy Specimens is a Potential Predictor of Primary Resistance to First-Line Treatment with Tyrosine Kinase Inhibitors in Patients with Metastatic Renal Cell Carcinoma. -other hsa-mir-128 Inflammation 30203508 NEAT1 contributes to ox-LDL-induced inflammation and oxidative stress in macrophages through inhibiting miR-128. -other hsa-mir-4633 Melanoma 30205394 Identification and Functional Evaluation of miR-4633-5p as a Biomarker and Tumor Suppressor in Metastatic Melanoma. -other hsa-mir-21 "Fatty Liver, Non-Alcoholic" 30206377 Targeting a phospho-STAT3-miRNAs pathway improves vesicular hepatic steatosis in an in vitro and in vivo model. -other hsa-mir-520a "Carcinoma, Thyroid, Papillary" 30206929 "MicroRNA-520a-3p suppresses epithelial-mesenchymal transition, invasion, and migration of papillary thyroid carcinoma cells via the JAK1-mediated JAK/STAT signaling pathway." -other hsa-mir-146a "Leukemia, Myeloid, Acute" 30208330 Upregulated microRNA-146a expression induced by granulocyte colony-stimulating factor enhanced low-dosage chemotherapy response in aged acute myeloid leukemia patients. -other hsa-mir-122 Hepatitis C Virus Infection 30209483 Simple and rational design of a polymer nano-platform for high performance of HCV related miR-122 reduction in the liver. -other hsa-mir-146a Obesity 30212608 Physical Activity Modulates the Overexpression of the Inflammatory miR-146a-5p in Obese Patients. -other hsa-mir-200c "Carcinoma, Breast" 30213797 Reversal of Triple-negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immune-Suppression. -other hsa-mir-203 "Carcinoma, Lung, Non-Small-Cell" 30214583 H19 contributes to poor clinical features in NSCLC patients and leads to enhanced invasion in A549 cells through regulating miRNA-203-mediated epithelial-mesenchymal transition. -other hsa-mir-214 Gastric Neoplasms 30215537 hsa_circ_0000993 may inhibit metastasis of gastric cancer through sequestering miR-214-5p -other hsa-mir-198 "Lymphoma, Large B-Cell, Diffuse" 30216798 Bortezomib inhibited the progression of diffuse large B-cell lymphoma via targeting miR-198. -other hsa-mir-27b "Adenocarcinoma, Esophageal" 30217293 microRNAs: Key regulators of chemotherapy response and metastatic potential via complex control of target pathways in esophageal adenocarcinoma. -other hsa-mir-1290 "Carcinoma, Cervical" 30219071 Exosomal miR-1290 is a potential biomarker of high-grade serous ovarian carcinoma and can discriminate patients from those with malignancies of other histological types. -other hsa-mir-146a Lung Injury [unspecific] 30220173 Effect and mechanism of MicroRNA-146a on TLR4 inflammatory signal pathway in the lung tissues of rats with mechanical ventilator-induced lung injury -other hsa-mir-155 Acute Lung Injury 30220274 miR-155 ASO has the effect of inhibiting LPS-induced inflammatory response and improving prognosis in ALI mice -other hsa-mir-142 Colon Neoplasms 30220706 BM-MSC-derived exosomes promote colon cancer stem cell-like traits via miR-142-3p -other hsa-mir-30 "Carcinoma, Pancreatic" 30221677 Establishment of a non?coding RNAomics screening platform for the regulation of KRAS in pancreatic cancer by RNA sequencing. -other hsa-mir-34 "Carcinoma, Pancreatic" 30221677 Establishment of a non?coding RNAomics screening platform for the regulation of KRAS in pancreatic cancer by RNA sequencing. -other hsa-mir-320 Inflammation 30224451 IL-33 promotes recovery from acute colitis by inducing miR-320 to stimulate epithelial restitution and repair. -other hsa-mir-124 Amyotrophic Lateral Sclerosis 30233312 we observed enhanced retrograde transport of miR-124-Cy3 -other hsa-mir-199a "Diabetes Mellitus, Type 2" 30233719 Reduced expression of microRNA-199a-3p is associated with vascular endothelial cell injury induced by type 2 diabetes mellitus. -other hsa-mir-191 Cholangiocarcinoma 30235453 miR-191 Inhibition Induces Apoptosis Through Reactivating Secreted Frizzled-Related Protein-1 in Cholangiocarcinoma. -other hsa-mir-21 Neoplasms [unspecific] 30237038 "we discuss the role of miR-21 and miR-375 in the RAS pathway as well as their role in cancer diagnosis and progression, along with the role of other select miRNAs in cancer immune surveillance" -other hsa-mir-375 Neoplasms [unspecific] 30237038 "we discuss the role of miR-21 and miR-375 in the RAS pathway as well as their role in cancer diagnosis and progression, along with the role of other select miRNAs in cancer immune surveillance" -other hsa-mir-221 Neoplasms [unspecific] 30237739 The correlation between microRNA-221/222 cluster overexpression and malignancy: an updated meta-analysis including 2693 patients. -other hsa-mir-222 Neoplasms [unspecific] 30237739 The correlation between microRNA-221/222 cluster overexpression and malignancy: an updated meta-analysis including 2693 patients. -other hsa-mir-106 "Carcinoma, Hepatocellular" 30238497 Development and validation of serum exosomal microRNAs as diagnostic and prognostic biomarkers for hepatocellular carcinoma. -other hsa-mir-17 Acute Respiratory Distress Syndrome 30239899 transfer of miR-17-5p strongly downregulated expression of the antiviral factor Mx1 and significantly enhanced IAV replication -other hsa-let-7a "Leukemia, Lymphoblastic, Acute, T-Cell" 30241379 "we then showed the utility of the combination of three miRNAs as endogenous normalizers (hsa-miR-16-5p, hsa-miR-25-3p, and hsa-let-7a-5p)" -other hsa-mir-16 "Leukemia, Lymphoblastic, Acute, T-Cell" 30241379 "we then showed the utility of the combination of three miRNAs as endogenous normalizers (hsa-miR-16-5p, hsa-miR-25-3p, and hsa-let-7a-5p)" -other hsa-mir-25 "Leukemia, Lymphoblastic, Acute, T-Cell" 30241379 "we then showed the utility of the combination of three miRNAs as endogenous normalizers (hsa-miR-16-5p, hsa-miR-25-3p, and hsa-let-7a-5p)" -other hsa-mir-34a Oral Neoplasms 30243489 Cancer-associated fibroblasts contribute to oral cancer cells proliferation and metastasis via exosome-mediated paracrine miR-34a-5p. -other hsa-mir-142 Idiopathic Pulmonary Fibrosis 30244194 we found a negative correlation between miR-142-3p and diffusing capacity of the lungs for carbon monoxide/alveolar volume -other hsa-mir-148a Ischemia-Reperfusion Injury 30244246 Role of miR-148a in Mitigating Hepatic Ischemia-Reperfusion Injury by Repressing the TLR4 Signaling Pathway via Targeting CaMKII¦Á in Vivo and in Vitro. -other hsa-mir-126 Sepsis 30244405 Application of Deacetylated Poly-N-Acetyl Glucosamine Nanoparticles for the Delivery of miR-126 for the Treatment of Cecal Ligation and Puncture-Induced Sepsis. -other hsa-mir-206 "Carcinoma, Lung, Non-Small-Cell" 30245277 "miR-206 and miR-613, were significantly associated with NSCLC" -other hsa-mir-613 "Carcinoma, Lung, Non-Small-Cell" 30245277 "miR-206 and miR-613, were significantly associated with NSCLC" -other hsa-mir-155 Asthma 30245919 MiR-155 may play a role in mediating allergic inflammation in T-cells and could be an anti-inflammatory target of steroids -other hsa-mir-146a "Carcinoma, Breast" 30245930 "The role of miRNAs 34a, 146a, 320a and 542 in the synergistic anticancer effects of methyl 2-(5-fluoro-2-hydroxyphenyl)-1H- benzo[d]imidazole-5-carboxylate (MBIC) with doxorubicin in breast cancer cells." -other hsa-mir-320a "Carcinoma, Breast" 30245930 "The role of miRNAs 34a, 146a, 320a and 542 in the synergistic anticancer effects of methyl 2-(5-fluoro-2-hydroxyphenyl)-1H- benzo[d]imidazole-5-carboxylate (MBIC) with doxorubicin in breast cancer cells." -other hsa-mir-34a "Carcinoma, Breast" 30245930 "The role of miRNAs 34a, 146a, 320a and 542 in the synergistic anticancer effects of methyl 2-(5-fluoro-2-hydroxyphenyl)-1H- benzo[d]imidazole-5-carboxylate (MBIC) with doxorubicin in breast cancer cells." -other hsa-mir-542 "Carcinoma, Breast" 30245930 "The role of miRNAs 34a, 146a, 320a and 542 in the synergistic anticancer effects of methyl 2-(5-fluoro-2-hydroxyphenyl)-1H- benzo[d]imidazole-5-carboxylate (MBIC) with doxorubicin in breast cancer cells." -other hsa-mir-15a Neoplasms [unspecific] 30246332 The miR-15a/16 gene cluster in human cancer: A systematic review. -other hsa-mir-16 Neoplasms [unspecific] 30246332 The miR-15a/16 gene cluster in human cancer: A systematic review. -other hsa-mir-1271 Glioblastoma 30248541 Chemo-resistance of A172 glioblastoma cells is controlled by miR-1271-regulated Bcl-2. -other hsa-mir-125a Gastrointestinal Stromal Tumor 30249101 Hsa-miR-28-5p and hsa-miR-125a-5p may be involved in the development and progression of GIST -other hsa-mir-28 Gastrointestinal Stromal Tumor 30249101 Hsa-miR-28-5p and hsa-miR-125a-5p may be involved in the development and progression of GIST -other hsa-mir-1247 "Carcinoma, Breast" 30249392 Downregulated miR-1247-5p associates with poor prognosis and facilitates tumor cell growth via DVL1/Wnt/¦Â-catenin signaling in breast cancer. -other hsa-mir-23 Coronary Artery Disease 30249504 miR-23 regulates cell proliferation and apoptosis of vascular smooth muscle cells in coronary heart disease. -other hsa-mir-195 "Carcinoma, Hepatocellular" 30249878 "Identification of potential transcription factors, long noncoding RNAs, and microRNAs associated with hepatocellular carcinoma." -other hsa-mir-196a "Squamous Cell Carcinoma, Esophageal" 30249885 Association of serum annexin A1 with treatment response and prognosis in patients with esophageal squamous cell carcinoma. -other hsa-mir-130a "Carcinoma, Breast" 30250584 Target gene prediction and pathway analysis revealed the involvement of miR-130a and miR-425 in pathways associated with malignant cell proliferation -other hsa-mir-425 "Carcinoma, Breast" 30250584 Target gene prediction and pathway analysis revealed the involvement of miR-130a and miR-425 in pathways associated with malignant cell proliferation -other hsa-mir-17 Small Intestine Carcinoma 30255827 Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and WNT-pathway-related markers of bowel cancer risk. -other hsa-mir-374a "Carcinoma, Hepatocellular" 30257238 "Propofol Inhibits Proliferation, Migration, Invasion and Promotes Apoptosis Through Down-Regulating miR-374a in Hepatocarcinoma Cell Lines." -other hsa-mir-23a Hypoxia 30257251 Astragaloside IV Protects Rat Cardiomyocytes from Hypoxia-Induced Injury by Down-Regulation of miR-23a and miR-92a. -other hsa-mir-92a Hypoxia 30257251 Astragaloside IV Protects Rat Cardiomyocytes from Hypoxia-Induced Injury by Down-Regulation of miR-23a and miR-92a. -other hsa-mir-106b Neoplasms [unspecific] 30257332 The emerging roles of the polycistronic miR-106b?25 cluster in cancer - A comprehensive review. -other hsa-mir-106 "Carcinoma, Bladder" 30257376 Baicalein inhibits proliferation and migration of bladder cancer cell line T24 by down-regulation of microRNA-106. -other hsa-mir-18a Glioma 30257388 c-Fos/microRNA-18a feedback loop modulates the tumor growth via HMBOX1 in human gliomas. -other hsa-mir-204 Diabetes Mellitus 30257973 miR-29c overexpression and miR-204 inhibition per se attenuated VSMC phenotypic switch in DM -other hsa-mir-29c Diabetes Mellitus 30257973 miR-29c overexpression and miR-204 inhibition per se attenuated VSMC phenotypic switch in DM -other hsa-mir-10a "Carcinoma, Breast" 30259272 MicroRNA Profiling of Salivary Duct Carcinoma Versus Her2/Neu Overexpressing Breast Carcinoma Identify miR-10a as a Putative Breast Related Oncogene. -other hsa-mir-124a Cardiovascular Diseases [unspecific] 30260095 "Pearson analysis revealed a correlation between MPs miR-124a and miR150 and adiponectin, TNF¦Á, or IL-6 levels" -other hsa-mir-150 Cardiovascular Diseases [unspecific] 30260095 "Pearson analysis revealed a correlation between MPs miR-124a and miR150 and adiponectin, TNF¦Á, or IL-6 levels" -other hsa-let-7e Melanoma 30260323 "we describe a set of microRNAs (miR-146a, miR-155, miR-125b, miR-100, let-7e, miR-125a, miR-146b, miR-99b) that are associated with MDSCs and with resistance to treatment with immune checkpoint inhibitors in melanoma patients" -other hsa-mir-100 Melanoma 30260323 "we describe a set of microRNAs (miR-146a, miR-155, miR-125b, miR-100, let-7e, miR-125a, miR-146b, miR-99b) that are associated with MDSCs and with resistance to treatment with immune checkpoint inhibitors in melanoma patients" -other hsa-mir-125a Melanoma 30260323 "we describe a set of microRNAs (miR-146a, miR-155, miR-125b, miR-100, let-7e, miR-125a, miR-146b, miR-99b) that are associated with MDSCs and with resistance to treatment with immune checkpoint inhibitors in melanoma patients" -other hsa-mir-125b Melanoma 30260323 "we describe a set of microRNAs (miR-146a, miR-155, miR-125b, miR-100, let-7e, miR-125a, miR-146b, miR-99b) that are associated with MDSCs and with resistance to treatment with immune checkpoint inhibitors in melanoma patients" -other hsa-mir-146a Melanoma 30260323 "we describe a set of microRNAs (miR-146a, miR-155, miR-125b, miR-100, let-7e, miR-125a, miR-146b, miR-99b) that are associated with MDSCs and with resistance to treatment with immune checkpoint inhibitors in melanoma patients" -other hsa-mir-146b Melanoma 30260323 "we describe a set of microRNAs (miR-146a, miR-155, miR-125b, miR-100, let-7e, miR-125a, miR-146b, miR-99b) that are associated with MDSCs and with resistance to treatment with immune checkpoint inhibitors in melanoma patients" -other hsa-mir-155 Melanoma 30260323 "we describe a set of microRNAs (miR-146a, miR-155, miR-125b, miR-100, let-7e, miR-125a, miR-146b, miR-99b) that are associated with MDSCs and with resistance to treatment with immune checkpoint inhibitors in melanoma patients" -other hsa-mir-99b Melanoma 30260323 "we describe a set of microRNAs (miR-146a, miR-155, miR-125b, miR-100, let-7e, miR-125a, miR-146b, miR-99b) that are associated with MDSCs and with resistance to treatment with immune checkpoint inhibitors in melanoma patients" -other hsa-mir-350 Inflammation 30260716 miR-350-3p Contributes to Age-Associated Impairment of IL-6 Production by Macrophages. -other hsa-mir-146a "Diabetes Mellitus, Type 1" 30260972 miR-146a-5p could play a role in type 1 diabetes development -other hsa-mir-200 Lung Neoplasms 30268479 Exosomal RNA-profiling of pleural effusions identifies adenocarcinoma patients through elevated miR-200 and LCN2 expression. -other hsa-mir-326 Cataract 30268497 MiR-326 antagomir delays the progression of age-related cataract by upregulating FGF1-mediated expression of betaB2-crystallin. -other hsa-mir-145 Psoriasis 30269330 Downregulation of miR-145-5p contributes to hyperproliferation of keratinocytes and skin inflammation in psoriasis. -other hsa-mir-122 "Fatty Liver, Non-Alcoholic" 30271077 "miR-34a, miR-122 and miR-155 are most involved in the pathogenesis of NAFLD" -other hsa-mir-155 "Fatty Liver, Non-Alcoholic" 30271077 "miR-34a, miR-122 and miR-155 are most involved in the pathogenesis of NAFLD" -other hsa-mir-34a "Fatty Liver, Non-Alcoholic" 30271077 "miR-34a, miR-122 and miR-155 are most involved in the pathogenesis of NAFLD" -other hsa-mir-132 Myocardial Infarction 30271437 "MicroRNA-132, Delivered by Mesenchymal Stem Cell-Derived Exosomes, Promote Angiogenesis in Myocardial Infarction." -other hsa-mir-3148 Neoplasms [unspecific] 30275189 miR-3148 Is a Novel Onco-microRNA that Potentiates Tumor Growth In Vivo. -other hsa-mir-138 Neoplasms [unspecific] 30278099 apigenin-induced apoptotic rate was significantly higher when used in combination with miR-423-5p inhibitors or miR-138 mimics -other hsa-mir-423 Neoplasms [unspecific] 30278099 apigenin-induced apoptotic rate was significantly higher when used in combination with miR-423-5p inhibitors or miR-138 mimics -other hsa-mir-141 Aneurysm 30280445 The mir-200 family regulates key pathogenic events in ascending aortas of individuals with bicuspid aortic valves. -other hsa-mir-200a Aneurysm 30280445 The mir-200 family regulates key pathogenic events in ascending aortas of individuals with bicuspid aortic valves. -other hsa-mir-200b Aneurysm 30280445 The mir-200 family regulates key pathogenic events in ascending aortas of individuals with bicuspid aortic valves. -other hsa-mir-200c Aneurysm 30280445 The mir-200 family regulates key pathogenic events in ascending aortas of individuals with bicuspid aortic valves. -other hsa-mir-429 Aneurysm 30280445 The mir-200 family regulates key pathogenic events in ascending aortas of individuals with bicuspid aortic valves. -other hsa-mir-378 Fatty Liver [unspecific] 30281809 LXR¦Á Promotes Hepatosteatosis in Part via Activation of MicroRNA-378 Transcription and Inhibition of Ppargc1¦Â Expression. -other hsa-mir-223 Diabetes Mellitus 30287053 "celastrol reverses PA-induced IR-related alterations, in part via miR-223 in HepG2 cells" -other hsa-mir-181a Osteoarthritis 30287418 microRNA-181a-5p antisense oligonucleotides attenuate osteoarthritis in facet and knee joints. -other hsa-mir-495 Thrombosis 30287499 Effect of microRNA-495 on lower extremity deep vein thrombosis through the TLR4 signaling pathway by regulation of IL1R1. -other hsa-mir-133a "Carcinoma, Oropharyngeal" 30289952 Smoking-induced control of miR-133a-3p alters the expression of EGFR and HuR in HPV-infected oropharyngeal cancer. -other hsa-mir-296 Neoplasms [unspecific] 30293950 Epigenetic mechanisms and upstream transcription factors are responsible for the regulation of miR-296 expression in cancer -other hsa-mir-15b Cardiovascular Diseases [unspecific] 30295821 "Our bioinformatic analysis revealed three highly expressed eNOS-targeting miRNAs (miR-15b, miR-16, and miR-30b) in human endothelial cells (ECs)" -other hsa-mir-16 Cardiovascular Diseases [unspecific] 30295821 "Our bioinformatic analysis revealed three highly expressed eNOS-targeting miRNAs (miR-15b, miR-16, and miR-30b) in human endothelial cells (ECs)" -other hsa-mir-30b Cardiovascular Diseases [unspecific] 30295821 "Our bioinformatic analysis revealed three highly expressed eNOS-targeting miRNAs (miR-15b, miR-16, and miR-30b) in human endothelial cells (ECs)" -other hsa-mir-29a Intervertebral Disc Degeneration 30296017 Sustained and Bioresponsive Two-Stage Delivery of Therapeutic miRNA via Polyplex Micelle-Loaded Injectable Hydrogels for Inhibition of Intervertebral Disc Fibrosis. -other hsa-mir-34 Heart Failure 30298011 Generation of MicroRNA-34 Sponges and Tough Decoys for the Heart: Developments and Challenges. -other hsa-mir-101 Atherosclerosis 30300747 "miR-10a, -19a, -23b, -17~92, -21, -663, -92a, -143/145, -101, -126, -712, -205, and -155 that play a critical role in endothelial function and atherosclerosis by targeting inflammation, cell cycle, proliferation, migration, apoptosis, and nitric oxide signaling" -other hsa-mir-10a Atherosclerosis 30300747 "miR-10a, -19a, -23b, -17~92, -21, -663, -92a, -143/145, -101, -126, -712, -205, and -155 that play a critical role in endothelial function and atherosclerosis by targeting inflammation, cell cycle, proliferation, migration, apoptosis, and nitric oxide signaling" -other hsa-mir-126 Atherosclerosis 30300747 "miR-10a, -19a, -23b, -17~92, -21, -663, -92a, -143/145, -101, -126, -712, -205, and -155 that play a critical role in endothelial function and atherosclerosis by targeting inflammation, cell cycle, proliferation, migration, apoptosis, and nitric oxide signaling" -other hsa-mir-143 Atherosclerosis 30300747 "miR-10a, -19a, -23b, -17~92, -21, -663, -92a, -143/145, -101, -126, -712, -205, and -155 that play a critical role in endothelial function and atherosclerosis by targeting inflammation, cell cycle, proliferation, migration, apoptosis, and nitric oxide signaling" -other hsa-mir-145 Atherosclerosis 30300747 "miR-10a, -19a, -23b, -17~92, -21, -663, -92a, -143/145, -101, -126, -712, -205, and -155 that play a critical role in endothelial function and atherosclerosis by targeting inflammation, cell cycle, proliferation, migration, apoptosis, and nitric oxide signaling" -other hsa-mir-155 Atherosclerosis 30300747 "miR-10a, -19a, -23b, -17~92, -21, -663, -92a, -143/145, -101, -126, -712, -205, and -155 that play a critical role in endothelial function and atherosclerosis by targeting inflammation, cell cycle, proliferation, migration, apoptosis, and nitric oxide signaling" -other hsa-mir-17 Atherosclerosis 30300747 "miR-10a, -19a, -23b, -17~92, -21, -663, -92a, -143/145, -101, -126, -712, -205, and -155 that play a critical role in endothelial function and atherosclerosis by targeting inflammation, cell cycle, proliferation, migration, apoptosis, and nitric oxide signaling" -other hsa-mir-18 Atherosclerosis 30300747 "miR-10a, -19a, -23b, -17~92, -21, -663, -92a, -143/145, -101, -126, -712, -205, and -155 that play a critical role in endothelial function and atherosclerosis by targeting inflammation, cell cycle, proliferation, migration, apoptosis, and nitric oxide signaling" -other hsa-mir-19a Atherosclerosis 30300747 "miR-10a, -19a, -23b, -17~92, -21, -663, -92a, -143/145, -101, -126, -712, -205, and -155 that play a critical role in endothelial function and atherosclerosis by targeting inflammation, cell cycle, proliferation, migration, apoptosis, and nitric oxide signaling" -other hsa-mir-19b-1 Atherosclerosis 30300747 "miR-10a, -19a, -23b, -17~92, -21, -663, -92a, -143/145, -101, -126, -712, -205, and -155 that play a critical role in endothelial function and atherosclerosis by targeting inflammation, cell cycle, proliferation, migration, apoptosis, and nitric oxide signaling" -other hsa-mir-205 Atherosclerosis 30300747 "miR-10a, -19a, -23b, -17~92, -21, -663, -92a, -143/145, -101, -126, -712, -205, and -155 that play a critical role in endothelial function and atherosclerosis by targeting inflammation, cell cycle, proliferation, migration, apoptosis, and nitric oxide signaling" -other hsa-mir-20a Atherosclerosis 30300747 "miR-10a, -19a, -23b, -17~92, -21, -663, -92a, -143/145, -101, -126, -712, -205, and -155 that play a critical role in endothelial function and atherosclerosis by targeting inflammation, cell cycle, proliferation, migration, apoptosis, and nitric oxide signaling" -other hsa-mir-21 Atherosclerosis 30300747 "miR-10a, -19a, -23b, -17~92, -21, -663, -92a, -143/145, -101, -126, -712, -205, and -155 that play a critical role in endothelial function and atherosclerosis by targeting inflammation, cell cycle, proliferation, migration, apoptosis, and nitric oxide signaling" -other hsa-mir-23b Atherosclerosis 30300747 "miR-10a, -19a, -23b, -17~92, -21, -663, -92a, -143/145, -101, -126, -712, -205, and -155 that play a critical role in endothelial function and atherosclerosis by targeting inflammation, cell cycle, proliferation, migration, apoptosis, and nitric oxide signaling" -other hsa-mir-663 Atherosclerosis 30300747 "miR-10a, -19a, -23b, -17~92, -21, -663, -92a, -143/145, -101, -126, -712, -205, and -155 that play a critical role in endothelial function and atherosclerosis by targeting inflammation, cell cycle, proliferation, migration, apoptosis, and nitric oxide signaling" -other hsa-mir-712 Atherosclerosis 30300747 "miR-10a, -19a, -23b, -17~92, -21, -663, -92a, -143/145, -101, -126, -712, -205, and -155 that play a critical role in endothelial function and atherosclerosis by targeting inflammation, cell cycle, proliferation, migration, apoptosis, and nitric oxide signaling" -other hsa-mir-92-1 Atherosclerosis 30300747 "miR-10a, -19a, -23b, -17~92, -21, -663, -92a, -143/145, -101, -126, -712, -205, and -155 that play a critical role in endothelial function and atherosclerosis by targeting inflammation, cell cycle, proliferation, migration, apoptosis, and nitric oxide signaling" -other hsa-mir-92a Atherosclerosis 30300747 "miR-10a, -19a, -23b, -17~92, -21, -663, -92a, -143/145, -101, -126, -712, -205, and -155 that play a critical role in endothelial function and atherosclerosis by targeting inflammation, cell cycle, proliferation, migration, apoptosis, and nitric oxide signaling" -other hsa-mir-155 "Carcinoma, Breast" 30301470 Specific microRNA signatures in exosomes of triple-negative and HER2-positive breast cancer patients undergoing neoadjuvant therapy within the GeparSixto trial. -other hsa-mir-301 "Carcinoma, Breast" 30301470 Specific microRNA signatures in exosomes of triple-negative and HER2-positive breast cancer patients undergoing neoadjuvant therapy within the GeparSixto trial. -other hsa-mir-155 Atrial Fibrillation 30302809 Ablation alleviates atrial fibrillation by regulating the signaling pathways of endothelial nitric oxide synthase/nitric oxide via miR-155-5p and miR-24-3p. -other hsa-mir-24 Atrial Fibrillation 30302809 Ablation alleviates atrial fibrillation by regulating the signaling pathways of endothelial nitric oxide synthase/nitric oxide via miR-155-5p and miR-24-3p. -other hsa-mir-125b "Carcinoma, Lung, Non-Small-Cell" 30305431 Reduced miR-125a-5p level in non-small-cell lung cancer is associated with tumour progression. -other hsa-mir-194 Spinal Cord Injuries 30308510 Lycium Barbarum Polysaccharides Alleviates Oxidative Damage Induced by H2O2 Through Down-Regulating MicroRNA-194 in PC-12 and SH-SY5Y Cells. -other hsa-mir-19a Giant Cell Tumor of Bone 30309658 Downregulation of miR-223 and miR-19a induces differentiation and promotes recruitment of osteoclast cells in giant-cell tumor of the bone via the Runx2/TWIST-RANK/RANKL pathway. -other hsa-mir-223 Giant Cell Tumor of Bone 30309658 Downregulation of miR-223 and miR-19a induces differentiation and promotes recruitment of osteoclast cells in giant-cell tumor of the bone via the Runx2/TWIST-RANK/RANKL pathway. -other hsa-mir-106a "Carcinoma, Breast" 30311168 "The three-miRNAs risk score (miR-19a, miR-93, and miR-106a) was developed using the TCGA cohort, which predicted poor prognosis (p?=?0.0005) independently of known clinical risk factors" -other hsa-mir-19a "Carcinoma, Breast" 30311168 "The three-miRNAs risk score (miR-19a, miR-93, and miR-106a) was developed using the TCGA cohort, which predicted poor prognosis (p?=?0.0005) independently of known clinical risk factors" -other hsa-mir-93 "Carcinoma, Breast" 30311168 "The three-miRNAs risk score (miR-19a, miR-93, and miR-106a) was developed using the TCGA cohort, which predicted poor prognosis (p?=?0.0005) independently of known clinical risk factors" -other hsa-mir-494 Cholangiocarcinoma 30314946 "MicroRNA-494-dependent WDHDI inhibition suppresses epithelial-mesenchymal transition, tumor growth and metastasis in cholangiocarcinoma." -other hsa-mir-224 Acute Coronary Syndrome 30317569 Downregulated microRNA-224 aggravates vulnerable atherosclerotic plaques and vascular remodeling in acute coronary syndrome through activation of the TGF-¦Â/Smad pathway. -other hsa-mir-370 Diabetic Nephropathy 30317577 Effects of microRNA-370 on mesangial cell proliferation and extracellular matrix accumulation by binding to canopy 1 in a rat model of diabetic nephropathy. -other hsa-mir-101 Neoplasms [unspecific] 30319254 Cationic graphene oxide nanoplatform mediates miR-101 delivery to promote apoptosis by regulating autophagy and stress. -other hsa-mir-143 Glioblastoma 30322013 Targeting MicroRNA-143 Leads to Inhibition of Glioblastoma Tumor Progression. -other hsa-mir-708 "Osteoporosis, Postmenopausal" 30322266 Identification of miR-708-5p in peripheral blood monocytes: Potential marker for postmenopausal osteoporosis in Mexican-Mestizo population. -other hsa-mir-143 Helicobacter pylori Infection 30324743 "the expression of miR-28-3p, miR-143-3p, miR-151a-3p, and miR-148a-3p were closely associated with H pylori infection" -other hsa-mir-148a Helicobacter pylori Infection 30324743 "the expression of miR-28-3p, miR-143-3p, miR-151a-3p, and miR-148a-3p were closely associated with H pylori infection" -other hsa-mir-151a Helicobacter pylori Infection 30324743 "the expression of miR-28-3p, miR-143-3p, miR-151a-3p, and miR-148a-3p were closely associated with H pylori infection" -other hsa-mir-28 Helicobacter pylori Infection 30324743 "the expression of miR-28-3p, miR-143-3p, miR-151a-3p, and miR-148a-3p were closely associated with H pylori infection" -other hsa-mir-449a Osteoarthritis 30326428 Inhibition of miR-449a Promotes Cartilage Regeneration and Prevents Progression of Osteoarthritis in In?Vivo Rat Models. -other hsa-mir-192 Polycystic Kidney Disease 30332302 Impact of miR-192 and miR-194 on cyst enlargement through EMT in autosomal dominant polycystic kidney disease. -other hsa-mir-194 Polycystic Kidney Disease 30332302 Impact of miR-192 and miR-194 on cyst enlargement through EMT in autosomal dominant polycystic kidney disease. -other hsa-mir-21 "Carcinoma, Cervical" 30332981 Deregulation of miR-21 and miR-29a in Cervical Cancer Related to HPV Infection. -other hsa-mir-29a "Carcinoma, Cervical" 30332981 Deregulation of miR-21 and miR-29a in Cervical Cancer Related to HPV Infection. -other hsa-mir-107 Graft-Versus-Host Disease 30333363 Decreased Expression of MicroRNA-107 in B Lymphocytes of Patients with Antibody-Mediated Renal Allograft Rejection. -other hsa-mir-3158 "Diabetes Mellitus, Gestational" 30335885 "The key transcription factors include Sp1 transcription factor, pancreatic and duodenal homeobox 1, and hepatocyte nuclear factor 4 alpha, whereas miRNA includes has-miR-5699-5p and has-miR-3158-3p" -other hsa-mir-5699 "Diabetes Mellitus, Gestational" 30335885 "The key transcription factors include Sp1 transcription factor, pancreatic and duodenal homeobox 1, and hepatocyte nuclear factor 4 alpha, whereas miRNA includes has-miR-5699-5p and has-miR-3158-3p" -other hsa-mir-315 White Spot Syndrome Virus Infection 30337920 White Spot Syndrome Virus-Induced Shrimp miR-315 Attenuates Prophenoloxidase Activation via PPAE3 Gene Suppression. -other hsa-mir-711 Ischemic Diseases [unspecific] 30338821 Dexmedetomidine protects liver cell line L-02 from oxygen-glucose deprivation-induced injury by down-regulation of microRNA-711. -other hsa-mir-485 "Carcinoma, Pancreatic" 30341009 Bioselection Reveals miR-99b and miR-485 as Enhancers of Adenoviral Oncolysis in Pancreatic Cancer. -other hsa-mir-99b "Carcinoma, Pancreatic" 30341009 Bioselection Reveals miR-99b and miR-485 as Enhancers of Adenoviral Oncolysis in Pancreatic Cancer. -other hsa-mir-133a Lung Neoplasms 30341388 Up-regulated miR-133a orchestrates epithelial-mesenchymal transition of airway epithelial cells. -other hsa-mir-132 Psychiatric Disorders 30342060 miR-132/212 is induced by stress and its dysregulation triggers anxiety-related behavior. -other hsa-mir-212 Psychiatric Disorders 30342060 miR-132/212 is induced by stress and its dysregulation triggers anxiety-related behavior. -other hsa-mir-31 "Carcinoma, Hepatocellular" 30342168 CircRNA has_circ_0078710 acts as the sponge of microRNA-31 involved in hepatocellular carcinoma progression. -other hsa-mir-19b "Carcinoma, Breast" 30343695 MiR-19b non-canonical binding is directed by HuR and confers chemosensitivity through regulation of P-glycoprotein in breast cancer. -other hsa-mir-122 Fatty Liver [unspecific] 30344495 "High Fat Diet-Induced miR-122 Regulates Lipid Metabolism and Fat Deposition in Genetically Improved Farmed Tilapia (GIFT, Oreochromis niloticus) Liver." -other hsa-mir-146a Coronary Artery Disease 30344699 Endothelial stem cells attenuate cardiac apoptosis via downregulating cardiac microRNA-146a in a rat model of coronary heart disease. -other hsa-mir-21 Neoplasms [unspecific] 30346694 Tumor Cell-Derived Extracellular Vesicle-Coated Nanocarriers: An Efficient Theranostic Platform for the Cancer-Specific Delivery of Anti-miR-21 and Imaging Agents. -other hsa-mir-28 "Leukemia, Lymphocytic, Chronic, B-Cell" 30348117 NDRG2 mRNA levels and miR-28-5p and miR-650 activity in chronic lymphocytic leukemia. -other hsa-mir-650 "Leukemia, Lymphocytic, Chronic, B-Cell" 30348117 NDRG2 mRNA levels and miR-28-5p and miR-650 activity in chronic lymphocytic leukemia. -other hsa-mir-106b "Carcinoma, Breast" 30348127 "Several age-related miRNAs correlated with clinical frailty (miR-106b, miR-191, miR-301a, miR-320b, miR-374a), as well as with other biomarkers of aging, particularly Interleukin-6 (IL-6) and Monocyte Chemoattractant Protein-1 (MCP-1) (miR-106b, miR-301a, miR-374a-5p, miR-378a-3p)" -other hsa-mir-191 "Carcinoma, Breast" 30348127 "Several age-related miRNAs correlated with clinical frailty (miR-106b, miR-191, miR-301a, miR-320b, miR-374a), as well as with other biomarkers of aging, particularly Interleukin-6 (IL-6) and Monocyte Chemoattractant Protein-1 (MCP-1) (miR-106b, miR-301a, miR-374a-5p, miR-378a-3p)" -other hsa-mir-301a "Carcinoma, Breast" 30348127 "Several age-related miRNAs correlated with clinical frailty (miR-106b, miR-191, miR-301a, miR-320b, miR-374a), as well as with other biomarkers of aging, particularly Interleukin-6 (IL-6) and Monocyte Chemoattractant Protein-1 (MCP-1) (miR-106b, miR-301a, miR-374a-5p, miR-378a-3p)" -other hsa-mir-320b "Carcinoma, Breast" 30348127 "Several age-related miRNAs correlated with clinical frailty (miR-106b, miR-191, miR-301a, miR-320b, miR-374a), as well as with other biomarkers of aging, particularly Interleukin-6 (IL-6) and Monocyte Chemoattractant Protein-1 (MCP-1) (miR-106b, miR-301a, miR-374a-5p, miR-378a-3p)" -other hsa-mir-374a "Carcinoma, Breast" 30348127 "Several age-related miRNAs correlated with clinical frailty (miR-106b, miR-191, miR-301a, miR-320b, miR-374a), as well as with other biomarkers of aging, particularly Interleukin-6 (IL-6) and Monocyte Chemoattractant Protein-1 (MCP-1) (miR-106b, miR-301a, miR-374a-5p, miR-378a-3p)" -other hsa-mir-6798 Glioblastoma 30349053 Ars2 promotes cell proliferation and tumorigenicity in glioblastoma through regulating miR-6798-3p. -other hsa-mir-132 Neuropsychiatric Disorders [unspecific] 30352481 MicroRNA-132 directs human periodontal ligament-derived neural crest stem cell neural differentiation. -other hsa-mir-34a "Carcinoma, Cervical" 30354014 co-incubation of these two MINRCs with U87MG and HeLa cells led to cell-selective delivery of miR-34a -other hsa-mir-148b IgA Nephropathy 30355654 Renal microRNA-148b is associated with megalin downregulation in IgA nephropathy. -other hsa-mir-122 Sepsis 30355788 "a group of host cellular microRNAs (miRNAs; miR-34a-5p, miR-122-5p, miR-145-5p, miR-146a-5p, miR-210-3p) are released into the blood during sepsis, some of which are capable of inducing complement activation, cytokine production, and leukocyte migration" -other hsa-mir-145 Sepsis 30355788 "a group of host cellular microRNAs (miRNAs; miR-34a-5p, miR-122-5p, miR-145-5p, miR-146a-5p, miR-210-3p) are released into the blood during sepsis, some of which are capable of inducing complement activation, cytokine production, and leukocyte migration" -other hsa-mir-146a Sepsis 30355788 "a group of host cellular microRNAs (miRNAs; miR-34a-5p, miR-122-5p, miR-145-5p, miR-146a-5p, miR-210-3p) are released into the blood during sepsis, some of which are capable of inducing complement activation, cytokine production, and leukocyte migration" -other hsa-mir-210 Sepsis 30355788 "a group of host cellular microRNAs (miRNAs; miR-34a-5p, miR-122-5p, miR-145-5p, miR-146a-5p, miR-210-3p) are released into the blood during sepsis, some of which are capable of inducing complement activation, cytokine production, and leukocyte migration" -other hsa-mir-34a Sepsis 30355788 "a group of host cellular microRNAs (miRNAs; miR-34a-5p, miR-122-5p, miR-145-5p, miR-146a-5p, miR-210-3p) are released into the blood during sepsis, some of which are capable of inducing complement activation, cytokine production, and leukocyte migration" -other hsa-mir-224 Colorectal Carcinoma 30361904 "The study highlighted the involvement of non-target genes VEGFA, TGF¦Â1, IGF1, CD105 and CD44 in mediating anti- and pro-migratory effect of miR-375 and miR-224, respectively, and validated MAP4K4 as a direct target of anti-migratory miR-145" -other hsa-mir-375 Colorectal Carcinoma 30361904 "The study highlighted the involvement of non-target genes VEGFA, TGF¦Â1, IGF1, CD105 and CD44 in mediating anti- and pro-migratory effect of miR-375 and miR-224, respectively, and validated MAP4K4 as a direct target of anti-migratory miR-145" -other hsa-mir-1972 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 30362598 hsa-miR-20a-3p and hsa-miR-1972 were noted to be important in the etiology of larynx cancer -other hsa-mir-20a "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 30362598 hsa-miR-20a-3p and hsa-miR-1972 were noted to be important in the etiology of larynx cancer -other hsa-mir-126 "Carcinoma, Lung, Small-Cell" 30364292 "MiR-126, DACH1, GRM8, MET, GSR, and HCP5 were implicated in the lymph node metastasis process of SCLC" -other hsa-mir-27a "Carcinoma, Breast" 30365154 miR?27a promotes human breast cancer cell migration by inducing EMT in a FBXW7?dependent manner. -other hsa-mir-34a Stroke 30365981 MiR-34a and stroke: Assessment of non-modifiable biological risk factors in cerebral ischemia. -other hsa-mir-146a Behcet Disease 30366049 Determination of mir-155 and mir-146a expression rates and its association with expression level of TNF-¦Á and CTLA4 genes in patients with Behcet's disease. -other hsa-mir-155 Behcet Disease 30366049 Determination of mir-155 and mir-146a expression rates and its association with expression level of TNF-¦Á and CTLA4 genes in patients with Behcet's disease. -other hsa-mir-135 "Diabetes Mellitus, Type 2" 30368872 "Network of three specific microRNAs(miR-135, miR-202, and miR-214) influence type 2 diabetes through inducing insulin resistance in muscle cell lines." -other hsa-mir-202 "Diabetes Mellitus, Type 2" 30368872 "Network of three specific microRNAs(miR-135, miR-202, and miR-214) influence type 2 diabetes through inducing insulin resistance in muscle cell lines." -other hsa-mir-214 "Diabetes Mellitus, Type 2" 30368872 "Network of three specific microRNAs(miR-135, miR-202, and miR-214) influence type 2 diabetes through inducing insulin resistance in muscle cell lines." -other hsa-mir-155 Atherosclerosis 30369883 Increased Expression of Resistin in MicroRNA-155-Deficient White Adipose Tissues May Be a Possible Driver of Metabolically Healthy Obesity Transition to Classical Obesity. -other hsa-mir-31 Neoplasms [unspecific] 30372817 Functions and mechanisms of microRNA-31 in human cancers. -other hsa-mir-378 Muscular Dystrophy 30373812 microRNA-378 promotes autophagy and inhibits apoptosis in skeletal muscle. -other hsa-mir-22 Hypertension 30375479 platelet miR-22 and miR-223 levels are reduced according to the hypertension status and they are negatively correlated with SBP levels -other hsa-mir-223 Hypertension 30375479 platelet miR-22 and miR-223 levels are reduced according to the hypertension status and they are negatively correlated with SBP levels -other hsa-mir-144 "Squamous Cell Carcinoma, Lung" 30375717 Involvement of dual-strand of the miR-144 duplex and their targets in the pathogenesis of lung squamous cell carcinoma. -other hsa-mir-122 "Carcinoma, Hepatocellular" 30377095 "we unveiled how HBV is deciphering the cellular miRNAs like miR-26a, miR-15a, miR-16-1, miR-148a, miR-132, miR-122, miR-34a, miR-21, miR-29a, miR-222 and miR-199a/b-3p to modulate the Wnt/FZD/¦Â-catenin signaling pathway and develop HCC" -other hsa-mir-132 "Carcinoma, Hepatocellular" 30377095 "we unveiled how HBV is deciphering the cellular miRNAs like miR-26a, miR-15a, miR-16-1, miR-148a, miR-132, miR-122, miR-34a, miR-21, miR-29a, miR-222 and miR-199a/b-3p to modulate the Wnt/FZD/¦Â-catenin signaling pathway and develop HCC" -other hsa-mir-148a "Carcinoma, Hepatocellular" 30377095 "we unveiled how HBV is deciphering the cellular miRNAs like miR-26a, miR-15a, miR-16-1, miR-148a, miR-132, miR-122, miR-34a, miR-21, miR-29a, miR-222 and miR-199a/b-3p to modulate the Wnt/FZD/¦Â-catenin signaling pathway and develop HCC" -other hsa-mir-15a "Carcinoma, Hepatocellular" 30377095 "we unveiled how HBV is deciphering the cellular miRNAs like miR-26a, miR-15a, miR-16-1, miR-148a, miR-132, miR-122, miR-34a, miR-21, miR-29a, miR-222 and miR-199a/b-3p to modulate the Wnt/FZD/¦Â-catenin signaling pathway and develop HCC" -other hsa-mir-16 "Carcinoma, Hepatocellular" 30377095 "we unveiled how HBV is deciphering the cellular miRNAs like miR-26a, miR-15a, miR-16-1, miR-148a, miR-132, miR-122, miR-34a, miR-21, miR-29a, miR-222 and miR-199a/b-3p to modulate the Wnt/FZD/¦Â-catenin signaling pathway and develop HCC" -other hsa-mir-199a "Carcinoma, Hepatocellular" 30377095 "we unveiled how HBV is deciphering the cellular miRNAs like miR-26a, miR-15a, miR-16-1, miR-148a, miR-132, miR-122, miR-34a, miR-21, miR-29a, miR-222 and miR-199a/b-3p to modulate the Wnt/FZD/¦Â-catenin signaling pathway and develop HCC" -other hsa-mir-199b "Carcinoma, Hepatocellular" 30377095 "we unveiled how HBV is deciphering the cellular miRNAs like miR-26a, miR-15a, miR-16-1, miR-148a, miR-132, miR-122, miR-34a, miR-21, miR-29a, miR-222 and miR-199a/b-3p to modulate the Wnt/FZD/¦Â-catenin signaling pathway and develop HCC" -other hsa-mir-21 "Carcinoma, Hepatocellular" 30377095 "we unveiled how HBV is deciphering the cellular miRNAs like miR-26a, miR-15a, miR-16-1, miR-148a, miR-132, miR-122, miR-34a, miR-21, miR-29a, miR-222 and miR-199a/b-3p to modulate the Wnt/FZD/¦Â-catenin signaling pathway and develop HCC" -other hsa-mir-222 "Carcinoma, Hepatocellular" 30377095 "we unveiled how HBV is deciphering the cellular miRNAs like miR-26a, miR-15a, miR-16-1, miR-148a, miR-132, miR-122, miR-34a, miR-21, miR-29a, miR-222 and miR-199a/b-3p to modulate the Wnt/FZD/¦Â-catenin signaling pathway and develop HCC" -other hsa-mir-26a "Carcinoma, Hepatocellular" 30377095 "we unveiled how HBV is deciphering the cellular miRNAs like miR-26a, miR-15a, miR-16-1, miR-148a, miR-132, miR-122, miR-34a, miR-21, miR-29a, miR-222 and miR-199a/b-3p to modulate the Wnt/FZD/¦Â-catenin signaling pathway and develop HCC" -other hsa-mir-29a "Carcinoma, Hepatocellular" 30377095 "we unveiled how HBV is deciphering the cellular miRNAs like miR-26a, miR-15a, miR-16-1, miR-148a, miR-132, miR-122, miR-34a, miR-21, miR-29a, miR-222 and miR-199a/b-3p to modulate the Wnt/FZD/¦Â-catenin signaling pathway and develop HCC" -other hsa-mir-34a "Carcinoma, Hepatocellular" 30377095 "we unveiled how HBV is deciphering the cellular miRNAs like miR-26a, miR-15a, miR-16-1, miR-148a, miR-132, miR-122, miR-34a, miR-21, miR-29a, miR-222 and miR-199a/b-3p to modulate the Wnt/FZD/¦Â-catenin signaling pathway and develop HCC" -other hsa-mir-122 Liver Neoplasms 30378424 Multiple MicroRNA Quantification Based on Acoustic Levitation of Single Microspheres after One-Pot Sandwich Interparticle Hybridizations. -other hsa-mir-21 Liver Neoplasms 30378424 Multiple MicroRNA Quantification Based on Acoustic Levitation of Single Microspheres after One-Pot Sandwich Interparticle Hybridizations. -other hsa-mir-168 Colorectal Carcinoma 30378765 "Plant-derived miR-168 is ubiquitously present in feces, normal mucosa and cancer" -other hsa-mir-155 Leukemia 30382602 "we discuss miR-155 dose-dependent effects in leukemias, and analyze results showing that miR-155 intermediate levels tend to be detrimental, while high levels of miR-155 expression usually prove beneficial" -other hsa-mir-105 Amyotrophic Lateral Sclerosis 30385300 MiR-105 and miR-9 regulate the mRNA stability of neuronal intermediate filaments. Implications for the pathogenesis of amyotrophic lateral sclerosis (ALS). -other hsa-mir-9 Amyotrophic Lateral Sclerosis 30385300 MiR-105 and miR-9 regulate the mRNA stability of neuronal intermediate filaments. Implications for the pathogenesis of amyotrophic lateral sclerosis (ALS). -other hsa-mir-30a Colorectal Carcinoma 30387187 miR-30a promoter variation contributes to the increased risk of colorectal cancer in an Iranian population. -other hsa-mir-21 Ischemia-Reperfusion Injury 23988020 "Our results demonstrate that besides miR-21, miR-17-5p, and miR-106a are additionally activated during the maintenance and recovery phases of renal I/R injury." -other hsa-mir-17 Ischemia-Reperfusion Injury 23988020 "Our results demonstrate that besides miR-21, miR-17-5p, and miR-106a are additionally activated during the maintenance and recovery phases of renal I/R injury." -other hsa-mir-106a Ischemia-Reperfusion Injury 23988020 "Our results demonstrate that besides miR-21, miR-17-5p, and miR-106a are additionally activated during the maintenance and recovery phases of renal I/R injury." -lncRNA target hsa-let-7a-1 Neoplasms [unspecific] 19211792 let-7a: Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation -lncRNA target hsa-let-7a-2 Neoplasms [unspecific] 19211792 let-7a: Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation -lncRNA target hsa-let-7a-3 Neoplasms [unspecific] 19211792 let-7a: Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation -lncRNA target hsa-let-7b Neoplasms [unspecific] 19211792 let-7b: Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation -lncRNA target hsa-let-7c Neoplasms [unspecific] 19211792 let-7c: Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation -lncRNA target hsa-let-7d Neoplasms [unspecific] 19211792 let-7d: Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation -lncRNA target hsa-let-7e Neoplasms [unspecific] 19211792 let-7e: Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation -lncRNA target hsa-let-7f-1 Neoplasms [unspecific] 19211792 let-7f: Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation -lncRNA target hsa-let-7f-2 Neoplasms [unspecific] 19211792 let-7f: Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation -lncRNA target hsa-let-7g Neoplasms [unspecific] 19211792 let-7g: Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation -lncRNA target hsa-let-7i Neoplasms [unspecific] 19211792 let-7i: Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation -lncRNA target hsa-let-7g Lung Neoplasms 19745602 increased with response to ionizing radiation when knockdown LIN28B -lncRNA target hsa-let-7a-1 Neoplasms [unspecific] 20005451 Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras -lncRNA target hsa-let-7a-2 Neoplasms [unspecific] 20005451 Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras -lncRNA target hsa-let-7a-3 Neoplasms [unspecific] 20005451 Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras -lncRNA target hsa-let-7b Neoplasms [unspecific] 20005451 Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras -lncRNA target hsa-let-7c Neoplasms [unspecific] 20005451 Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras -lncRNA target hsa-let-7d Neoplasms [unspecific] 20005451 Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras -lncRNA target hsa-let-7e Neoplasms [unspecific] 20005451 Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras -lncRNA target hsa-let-7f-1 Neoplasms [unspecific] 20005451 Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras -lncRNA target hsa-let-7f-2 Neoplasms [unspecific] 20005451 Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras -lncRNA target hsa-let-7g Neoplasms [unspecific] 20005451 Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras -lncRNA target hsa-let-7i Neoplasms [unspecific] 20005451 Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras -lncRNA target hsa-let-7a Retinal Degeneration 20935637 The opposing actions of Lin-28 and let-7 miRNAs on M¨¹ller glia differentiation and dedifferentiation are similar to that of embryonic stem cells and suggest novel targets for stimulating M¨¹ller glia dedifferentiation and retinal regeneration in mammals. -lncRNA target hsa-let-7b Retinal Degeneration 20935637 The opposing actions of Lin-28 and let-7 miRNAs on M¨¹ller glia differentiation and dedifferentiation are similar to that of embryonic stem cells and suggest novel targets for stimulating M¨¹ller glia dedifferentiation and retinal regeneration in mammals. -lncRNA target hsa-let-7c Retinal Degeneration 20935637 The opposing actions of Lin-28 and let-7 miRNAs on M¨¹ller glia differentiation and dedifferentiation are similar to that of embryonic stem cells and suggest novel targets for stimulating M¨¹ller glia dedifferentiation and retinal regeneration in mammals. -lncRNA target hsa-let-7d Retinal Degeneration 20935637 The opposing actions of Lin-28 and let-7 miRNAs on M¨¹ller glia differentiation and dedifferentiation are similar to that of embryonic stem cells and suggest novel targets for stimulating M¨¹ller glia dedifferentiation and retinal regeneration in mammals. -lncRNA target hsa-let-7e Retinal Degeneration 20935637 The opposing actions of Lin-28 and let-7 miRNAs on M¨¹ller glia differentiation and dedifferentiation are similar to that of embryonic stem cells and suggest novel targets for stimulating M¨¹ller glia dedifferentiation and retinal regeneration in mammals. -lncRNA target hsa-let-7f Retinal Degeneration 20935637 The opposing actions of Lin-28 and let-7 miRNAs on M¨¹ller glia differentiation and dedifferentiation are similar to that of embryonic stem cells and suggest novel targets for stimulating M¨¹ller glia dedifferentiation and retinal regeneration in mammals. -lncRNA target hsa-let-7g Retinal Degeneration 20935637 The opposing actions of Lin-28 and let-7 miRNAs on M¨¹ller glia differentiation and dedifferentiation are similar to that of embryonic stem cells and suggest novel targets for stimulating M¨¹ller glia dedifferentiation and retinal regeneration in mammals. -lncRNA target hsa-let-7i Retinal Degeneration 20935637 The opposing actions of Lin-28 and let-7 miRNAs on M¨¹ller glia differentiation and dedifferentiation are similar to that of embryonic stem cells and suggest novel targets for stimulating M¨¹ller glia dedifferentiation and retinal regeneration in mammals. -lncRNA target hsa-let-7a Neoplasms [unspecific] 21045151 "Our data provide evidence that cancer stem cells may arise through a ""reprogramming-like"" mechanism. A rebalancing of the LIN28/let-7 regulatory loop could be a novel therapeutic strategy to target ALDH1+ cancer stem cells." -lncRNA target hsa-let-7b Neoplasms [unspecific] 21045151 "Our data provide evidence that cancer stem cells may arise through a ""reprogramming-like"" mechanism. A rebalancing of the LIN28/let-7 regulatory loop could be a novel therapeutic strategy to target ALDH1+ cancer stem cells." -lncRNA target hsa-let-7c Neoplasms [unspecific] 21045151 "Our data provide evidence that cancer stem cells may arise through a ""reprogramming-like"" mechanism. A rebalancing of the LIN28/let-7 regulatory loop could be a novel therapeutic strategy to target ALDH1+ cancer stem cells." -lncRNA target hsa-let-7d Neoplasms [unspecific] 21045151 "Our data provide evidence that cancer stem cells may arise through a ""reprogramming-like"" mechanism. A rebalancing of the LIN28/let-7 regulatory loop could be a novel therapeutic strategy to target ALDH1+ cancer stem cells." -lncRNA target hsa-let-7e Neoplasms [unspecific] 21045151 "Our data provide evidence that cancer stem cells may arise through a ""reprogramming-like"" mechanism. A rebalancing of the LIN28/let-7 regulatory loop could be a novel therapeutic strategy to target ALDH1+ cancer stem cells." -lncRNA target hsa-let-7f Neoplasms [unspecific] 21045151 "Our data provide evidence that cancer stem cells may arise through a ""reprogramming-like"" mechanism. A rebalancing of the LIN28/let-7 regulatory loop could be a novel therapeutic strategy to target ALDH1+ cancer stem cells." -lncRNA target hsa-let-7g Neoplasms [unspecific] 21045151 "Our data provide evidence that cancer stem cells may arise through a ""reprogramming-like"" mechanism. A rebalancing of the LIN28/let-7 regulatory loop could be a novel therapeutic strategy to target ALDH1+ cancer stem cells." -lncRNA target hsa-let-7i Neoplasms [unspecific] 21045151 "Our data provide evidence that cancer stem cells may arise through a ""reprogramming-like"" mechanism. A rebalancing of the LIN28/let-7 regulatory loop could be a novel therapeutic strategy to target ALDH1+ cancer stem cells." -lncRNA target hsa-let-7a-1 Breast Neoplasms 22081076 LIN28: A regulator of tumor-suppressing activity of let-7 microRNA in human breast cancer. -lncRNA target hsa-let-7a-2 Breast Neoplasms 22081076 LIN28: A regulator of tumor-suppressing activity of let-7 microRNA in human breast cancer. -lncRNA target hsa-let-7a-3 Breast Neoplasms 22081076 LIN28: A regulator of tumor-suppressing activity of let-7 microRNA in human breast cancer. -lncRNA target hsa-let-7c Breast Neoplasms 22081076 LIN28: A regulator of tumor-suppressing activity of let-7 microRNA in human breast cancer. -lncRNA target hsa-let-7d Breast Neoplasms 22081076 LIN28: A regulator of tumor-suppressing activity of let-7 microRNA in human breast cancer. -lncRNA target hsa-let-7f-1 Breast Neoplasms 22081076 LIN28: A regulator of tumor-suppressing activity of let-7 microRNA in human breast cancer. -lncRNA target hsa-let-7f-2 Breast Neoplasms 22081076 LIN28: A regulator of tumor-suppressing activity of let-7 microRNA in human breast cancer. -lncRNA target hsa-let-7a-1 Breast Neoplasms 22808086 "Lin28 Mediates Paclitaxel Resistance by Modulating p21, Rb and Let-7a miRNA in Breast Cancer Cells." -lncRNA target hsa-let-7a-2 Breast Neoplasms 22808086 "Lin28 Mediates Paclitaxel Resistance by Modulating p21, Rb and Let-7a miRNA in Breast Cancer Cells." -lncRNA target hsa-let-7a-3 Breast Neoplasms 22808086 "Lin28 Mediates Paclitaxel Resistance by Modulating p21, Rb and Let-7a miRNA in Breast Cancer Cells." -lncRNA target hsa-let-7 Perlman Syndrome 23594738 A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway. -lncRNA target hsa-mir-221 Atherosclerosis 23697773 "We further discovered that an Ang II-regulated lncRNA functions as the host transcript for miR-221 and miR-222, 2 microRNAs implicated in cell proliferation. " -lncRNA target hsa-mir-675 Gastric Neoplasms 24388988 The long non-coding RNA H19-derived miR-675 modulates human gastric cancer cell proliferation by targeting tumor suppressor RUNX1. -lncRNA target hsa-mir-675 Glioma 24466011 Long non-coding RNA H19 promotes glioma cell invasion by deriving miR-675. -lncRNA target hsa-mir-21 Osteoarthritis 25196583 "A long non-coding RNA, GAS5, plays a critical role in the regulation of miR-21 during osteoarthritis." -lncRNA target hsa-mir-216b "Carcinoma, Hepatocellular" 25760077 Upregulated lncRNA-UCA1 contributes to progression of hepatocellular carcinoma through inhibition of miR-216b and activation of FGFR1/ERK signaling pathway. -lncRNA target hsa-mir-193a "Leukemia, Myeloid, Acute" 25979172 Long non-coding RNA HOTAIR modulates c-KIT expression through sponging miR-193a in acute myeloid leukemia. -lncRNA target hsa-mir-200c Gastric Neoplasms 25986864 LncRNA-ATB plays an important role in EMT to promote invasion and metastasis through the TGF-β/miR-200s/ZEB axis -lncRNA target hsa-let-7 Melanoma 26071398 "we discovered that Lin28B, a well-characterized inhibitor of let-7 miRNA biogenesis, was a direct target of miR-125a-5p in melanoma." -lncRNA target hsa-mir-107 Neoplasms [unspecific] 26158177 Lin28 could mediate cancer chemotherapy resistance via regulation of miR107 and Let-7 MiRNA. -lncRNA target hsa-mir-152 Gastric Neoplasms 26187665 Long non-coding RNA HOTAIR promotes HLA-G expression via inhibiting miR-152 in gastric cancer cells. -lncRNA target hsa-mir-145 Cervical Neoplasms 26311052 Long non-coding RNA MALAT1 modulates radiosensitivity of HR-HPV+ cervical cancer via sponging miR-145. -lncRNA target hsa-let-7 Neoplasms [unspecific] 26440890 These findings refine the current model of let-7 regulation by LIN28 proteins and have important implications for understanding the LIN28/let-7 axis in development and disease. -lncRNA target hsa-mir-222 Liver Fibrosis 26446789 GAS5 could directly bind to miR-222. -lncRNA target hsa-mir-141 "Carcinoma, Renal Cell, Clear-Cell" 26461224 LncRNA MALAT1 functions as a competing endogenous RNA to regulate ZEB2 expression by sponging miR-200s in clear cell kidney carcinoma. -lncRNA target hsa-mir-200a "Carcinoma, Renal Cell, Clear-Cell" 26461224 LncRNA MALAT1 functions as a competing endogenous RNA to regulate ZEB2 expression by sponging miR-200s in clear cell kidney carcinoma. -lncRNA target hsa-mir-200b "Carcinoma, Renal Cell, Clear-Cell" 26461224 LncRNA MALAT1 functions as a competing endogenous RNA to regulate ZEB2 expression by sponging miR-200s in clear cell kidney carcinoma. -lncRNA target hsa-mir-200c "Carcinoma, Renal Cell, Clear-Cell" 26461224 LncRNA MALAT1 functions as a competing endogenous RNA to regulate ZEB2 expression by sponging miR-200s in clear cell kidney carcinoma. -lncRNA target hsa-mir-429 "Carcinoma, Renal Cell, Clear-Cell" 26461224 LncRNA MALAT1 functions as a competing endogenous RNA to regulate ZEB2 expression by sponging miR-200s in clear cell kidney carcinoma. -lncRNA target hsa-mir-103 "Carcinoma, Endometrial" 26511107 "In summary, we demonstrate that GAS5 acts as an tumor suppressor lncRNA in endometrial cancer. Through inhibiting the expression of miR-103, GAS5 significantly enhanced the expression of PTEN to promote cancer cell apoptosis,and, thus, could be an important mediator in the pathogenesis of endometrial cancer." -lncRNA target hsa-mir-320a Embryonal Testis Carcinoma 26539909 "The accumulation of NLC1-C in the nucleus repressed miR-320a and miR-383 transcript and promoted testicular embryonal carcinoma cell proliferation by binding to Nucleolin. Here, we define a novel mechanism by which lncRNAs modulate miRNA expression at the transcriptional level by binding to RNA-binding proteins to regulate human spermatogenesis." -lncRNA target hsa-mir-193b "Adenocarcinoma, Pancreatic Ductal" 26549028 MIR31HG is negatively regulated by miR-193b. -lncRNA target hsa-mir-107 Gastric Neoplasms 26636340 Our results suggest that the Lin28/miR-107 pathway could be one of many signaling pathways regulated by Lin28 and associated with gastric cancer chemo-resistance. -lncRNA target hsa-mir-145 Pancreatic Neoplasms 26636540 ROR functions as a ceRNA to regulate Nanog expression by sponging miR-145 and predicts poor prognosis in pancreatic cancer. -lncRNA target hsa-mir-194 "Carcinoma, Gallbladder" 26803515 "overexpression of H19 in GBC-SD cells downregulated miR-194-5p and markedly increased AKT2 expression, and miR-194-5p mimic reversed these effects." -lncRNA target hsa-mir-485 Ovarian Neoplasms 26867765 UCA1 could function as an endogenous sponge by directly binding to miR-485-5p. -lncRNA target hsa-mir-9 Atherosclerosis 26981838 HULC regulated TNF-α-induced apoptosis through regulation of miR-9 expression. -lncRNA target hsa-mir-10a "Carcinoma, Hepatocellular" 27002617 Long non-coding RNA TUSC7 acts a molecular sponge for miR-10a and suppresses EMT in hepatocellular carcinoma. -lncRNA target hsa-mir-204 "Carcinoma, Nasopharyngeal" 27020592 The long non-coding RNA NEAT1 regulates epithelial to mesenchymal transition and radioresistance in through miR-204/ZEB1 axis in nasopharyngeal carcinoma. -lncRNA target hsa-mir-384 Glioma 27058823 "Moreover, CRNDE promoted cell malignant behavior by decreasing miR-384 expression." -lncRNA target hsa-mir-374a "Carcinoma, Hepatocellular" 27065331 Long noncoding RNA FTX inhibits hepatocellular carcinoma proliferation and metastasis by binding MCM2 and miR-374a. -lncRNA target hsa-mir-145 Colon Neoplasms 27071407 "Knockdown of lincRNA-ROR restored the expression of miR-145, and had a significant influence on colon cancer cell proliferation, migration and invasion." -lncRNA target hsa-mir-206 Gastric Neoplasms 27192121 "Acting as a miR-206 sponge, RMRP modulated cell cycle by regulating Cyclin D2 expression." -lncRNA target hsa-mir-218 Lung Neoplasms 27212446 miR-218 is negatively regulated by CCAT1 in HBE cells exposed to CSE. -lncRNA target hsa-mir-143 Neuroblastoma 27263970 Binding and release of miR-143-3p by LncND control the expression of Notch receptors. -lncRNA target hsa-mir-10a Glioblastoma 27270310 Long noncoding RNA RP11-838N2.4 enhances the cytotoxic effects of temozolomide by inhibiting the functions of miR-10a in glioblastoma cell lines. -lncRNA target hsa-mir-299 Glioblastoma 27345398 TUG1 enhances tumor-induced angiogenesis and VEGF expression through inhibiting miR-299. -lncRNA target hsa-mir-26a "Carcinoma, Gallbladder" 27345740 Upregulation of MINCR and enhancer of zeste homolog 2 (EZH2) in GBC coincided with the downregulation of miR-26a-5p in GBC. -lncRNA target hsa-mir-26a Glioma 27363339 Long non-coding RNA TUG1 acts as a miR-26a sponge in human glioma cells -lncRNA target hsa-mir-507 Melanoma 27389544 "We found that miR-507 could directly bind to UCA1 at the miRNA recognition site, and that there was a negative correlation between miR-507 and UCA1." -lncRNA target hsa-mir-139 Glioma 27434586 "HCP5 regulated the malignant behavior of glioma cells by binding to microRNA-139, which functions as a tumor suppressor." -lncRNA target hsa-mir-34a "Carcinoma, Nasopharyngeal" 27461945 Long non-coding RNA XIST exerts oncogenic functions in human nasopharyngeal carcinoma by targeting miR-34a-5p -lncRNA target hsa-mir-373 "Carcinoma, Ovarian" 27484896 LncRNA HOTAIR controls the expression of Rab22a by sponging miR-373 in ovarian cancer. -lncRNA target hsa-let-7a Cervical Neoplasms 27487126 LncRNA RSU1P2 contributes to tumorigenesis by acting as a ceRNA against let-7a in cervical cancer cells. -lncRNA target hsa-mir-125a Immune Thrombocytopenic Purpura 27522004 Long non-coding RNA MEG3 inhibits microRNA-125a-5p expression and induces immune imbalance of Treg/Th17 in immune thrombocytopenic purpura. -lncRNA target hsa-mir-34a Osteoarthritis 27529373 "Furthermore, we found that UFC1 regulates survival of OA chondrocytes through physically association with miR-34a." -lncRNA target hsa-let-7 Neoplasms [unspecific] 27548809 "We anticipate that much can be learned from the use of this first reported small molecule antagonist of Lin28, including the potential of the Lin28/let-7 interaction as a new drug target for selected cancers" -lncRNA target hsa-let-7c "Adenocarcinoma, Lung" 27566568 the oncogenic function of CCAT1 in docetaxel-resistant LAD cells depended on the sponging of let-7c -lncRNA target hsa-mir-148a "Carcinoma, Cervical" 27574106 Long non-coding RNA HOTAIR modulates HLA-G expression by absorbing miR-148a in human cervical cancer. -lncRNA target hsa-mir-196a "Carcinoma, Bladder" 27591936 Long non-coding RNA UCA1 promotes cisplatin/gemcitabine resistance through CREB modulating miR-196a-5p in bladder cancer cells. -lncRNA target hsa-mir-140 "Carcinoma, Hepatocellular" 27597739 Long non-coding RNA Unigene56159 promotes epithelial-mesenchymal transition by acting as a ceRNA of miR-140-5p in hepatocellular carcinoma cells. -lncRNA target hsa-mir-645 Osteosarcoma 27609068 Long non-coding RNA LINC00161 sensitises osteosarcoma cells to cisplatin-induced apoptosis by regulating the miR-645-IFIT2 axis. -lncRNA target hsa-mir-181b Liver Cirrhosis 27610008 Identification of a Novel lincRNA-p21-miR-181b-PTEN Signaling Cascade in Liver Fibrosis. -lncRNA target hsa-mir-18a "Carcinoma, Breast" 27629141 Long non-coding RNA UCA1 enhances tamoxifen resistance in breast cancer cells through a miR-18a-HIF1¦Á feedback regulatory loop. -lncRNA target hsa-mir-197 "Carcinoma, Bladder" 27631965 LINC00312 inhibits the migration and invasion of bladder cancer cells by targeting miR-197-3p. -lncRNA target hsa-mir-193a "Carcinoma, Colon" 27633443 the involvement of competing endogenous RNAs mechanism in Linc00152/miR-193a-3p/ERBB4/AKT signaling axis may provide a novel choice in the investigation of drug resistance -lncRNA target hsa-mir-150 Myocardial Infarction 27649667 LncRNA MIAT enhances cardiac hypertrophy partly through sponging miR-150. -lncRNA target hsa-mir-1297 "Carcinoma, Gastric" 27651312 "HOXA11-AS/miR-1297/EZH2 cross-talk serve as critical effectors in gastric cancer tumorigenesis and progression, suggesting new therapeutic directions in gastric cancer" -lncRNA target hsa-mir-9 Osteosarcoma 27658774 Long non-coding RNA TUG1 contributes to tumorigenesis of human osteosarcoma by sponging miR-9-5p and regulating POU2F1 expression. -lncRNA target hsa-mir-204 "Carcinoma, Esophageal" 27667646 lncRNA-UCA1 enhances cell proliferation through functioning as a ceRNA of Sox4 in esophageal cancer. -lncRNA target hsa-mir-494 "Carcinoma, Hepatocellular" 27689326 An artificial lncRNA targeting multiple miRNAs overcomes sorafenib resistance in hepatocellular carcinoma cells. -lncRNA target hsa-mir-140 Glioma 27693036 The lncRNA H19 interacts with miR-140 to modulate glioma growth by targeting iASPP. -lncRNA target hsa-mir-200c "Carcinoma, Endometrioid Endometrial" 27693631 Disrupting MALAT1/miR-200c sponge decreases invasion and migration in endometrioid endometrial carcinoma. -lncRNA target hsa-mir-27b "Carcinoma, Gastric" 27694794 Long Non-Coding RNA (LncRNA) Urothelial Carcinoma Associated 1 (UCA1) Increases Multi-Drug Resistance of Gastric Cancer via Downregulating miR-27b. -lncRNA target hsa-mir-125b Leukemia 27740626 "HOTAIRM1 was revealed to act as a microRNA sponge in a pathway that included miR-20a/106b, miR-125b and their targets ULK1, E2F1 and DRAM2" -lncRNA target hsa-mir-410 Glioma 27765628 Long non-coding RNA CCAT1 promotes glioma cell proliferation via inhibiting microRNA-410. -lncRNA target hsa-mir-124 "Carcinoma, Pancreatic" 27785603 Linc-ROR confers gemcitabine resistance to pancreatic cancer cells via inducing autophagy and modulating the miR-124/PTBP1/PKM2 axis. -lncRNA target hsa-mir-146a Prostate Neoplasms 27794184 LncRNA PVT1 regulates prostate cancer cell growth by inducing the methylation of miR-146a. -lncRNA target hsa-mir-195 Osteosarcoma 27813492 Long non-coding RNA PVT1 promotes osteosarcoma development by acting as a molecular sponge to regulate miR-195. -lncRNA target hsa-mir-200 "Carcinoma, Lung" 27852821 MEG3 regulated the recruitment of JARID2 and EZH2 and histone H3 methylation on the regulatory regions of CDH1 and microRNA-200 family genes for transcriptional repression -lncRNA target hsa-mir-16 Leukemia 27854515 lncRNA UCA1 Contributes to Imatinib Resistance by Acting as a ceRNA Against miR-16 in Chronic Myeloid Leukemia Cells. -lncRNA target hsa-mir-32 "Carcinoma, Gastric" 27871067 The lncRNA SNHG5/miR-32 axis regulates gastric cancer cell proliferation and migration by targeting KLF4. -lncRNA target hsa-mir-107 Glioma 27878295 Silencing of the long non-coding RNA NEAT1 suppresses glioma stem-like properties through modulation of the miR-107/CDK6 pathway. -lncRNA target hsa-mir-506 "Carcinoma, Pancreatic" 27888106 Long non-coding RNA NEAT1 facilitates pancreatic cancer progression through negative modulation of miR-506-3p. -lncRNA target hsa-mir-206 "Carcinoma, Lung" 27906963 "RMRP acted as an oncogene LncRNA to promote the expression of KRAS, FMNL2 and SOX9 by inhibiting miR-206 expression in lung cancer" -lncRNA target hsa-mir-195 "Carcinoma, Hepatocellular" 27932778 Expression of Long Non-Coding RNA (lncRNA) Small Nucleolar RNA Host Gene 1 (SNHG1) Exacerbates Hepatocellular Carcinoma Through Suppressing miR-195. -lncRNA target hsa-mir-23c Diabetic Nephropathy 27964927 Long noncoding RNA MALAT1 regulates renal tubular epithelial pyroptosis by modulated miR-23c targeting of ELAVL1 in diabetic nephropathy. -lncRNA target hsa-mir-183 Melanoma 27966454 Deregulation of miR-183 promotes melanoma development via lncRNA MALAT1 regulation and ITGB1 signal activation. -lncRNA target hsa-mir-675 Glioma 27981546 "LncRNA H19 is overexpressed in glioma tissue, is negatively associated with patient survival, and promotes tumor growth through its derivative miR-675." -lncRNA target hsa-mir-101 "Carcinoma, Bladder" 27998761 LncRNA SPRY4-IT1 sponges miR-101-3p to promote proliferation and metastasis of bladder cancer cells through up-regulating EZH2. -lncRNA target hsa-mir-214 "Carcinoma, Thyroid" 28000845 Long non-coding RNA NEAT1 promotes malignant progression of thyroid carcinoma by regulating miRNA-214. -lncRNA target hsa-mir-101 "Carcinoma, Breast" 28034643 The long non-coding RNA NEAT1 interacted with miR-101 modulates breast cancer growth by targeting EZH2. -lncRNA target hsa-mir-15a "Carcinoma, Hepatocellular" 28035067 "Long non-coding RNA AK058003, as a precursor of miR-15a, interacts with HuR to inhibit the expression of ¦Ã-synuclein in hepatocellular carcinoma cells." -lncRNA target hsa-mir-9 Breast Neoplasms 28053623 LncRNA Taurine-Upregulated Gene 1 Promotes Cell Proliferation by Inhibiting MicroRNA-9 in MCF-7 Cells. -lncRNA target hsa-mir-204 Choriocarcinoma 28059437 "Long Non-Coding RNA MALAT1 Interacts With miR-204 to Modulate Human Hilar Cholangiocarcinoma Proliferation, Migration, and Invasion by Targeting CXCR4." -lncRNA target hsa-mir-205 "Carcinoma, Breast" 28063065 Effects of long noncoding RNA-ROR on tamoxifen resistance of breast cancer cells by regulating microRNA-205. -lncRNA target hsa-mir-200a "Leukemia, Myeloid, Chronic" 28069548 HULC could modulate c-Myc and Bcl-2 by miR-200a as an endogenous sponge -lncRNA target hsa-mir-218 Colorectal Carcinoma 28069878 "the interaction between lncRNA MALAT1 and miR-218 was observed, which further indicated its prognostic value in patients who received standard FOLFOX treatment" -lncRNA target hsa-let-7 Malignant Neoplasms [unspecific] 28076679 Molecular Dynamics Simulations for Deciphering the Structural Basis of Recognition of Pre-let-7 miRNAs by LIN28. -lncRNA target hsa-mir-181a Colorectal Carcinoma 28086904 The lncRNA CRNDE promotes colorectal cancer cell proliferation and chemoresistance via miR-181a-5p-mediated regulation of Wnt/¦Â-catenin signaling. -lncRNA target hsa-mir-218 Retinoblastoma 28088735 Long non-coding RNA CCAT1 promotes human retinoblastoma SO-RB50 and Y79 cells through negative regulation of miR-218-5p. -lncRNA target hsa-mir-224 "Squamous Cell Carcinoma, Oral" 28093311 Long non-coding RNA FTH1P3 facilitates oral squamous cell carcinoma progression by acting as a molecular sponge of miR-224-5p to modulate fizzled 5 expression. -lncRNA target hsa-let-7a "Carcinoma, Nasopharyngeal" 28117929 Downregulation of lncRNA ANRIL represses tumorigenicity and enhances cisplatin-induced cytotoxicity via regulating microRNA let-7a in nasopharyngeal carcinoma. -lncRNA target hsa-mir-181a Glioma 28121023 LncRNA CASC2 Interacts With miR-181a to Modulate Glioma Growth and Resistance to TMZ Through PTEN Pathway. -lncRNA target hsa-mir-186 "Carcinoma, Gastric" 28122299 The long noncoding RNA PVT1 functions as a competing endogenous RNA by sponging miR-186 in gastric cancer. -lncRNA target hsa-mir-29b Liver Cirrhosis 28129115 HOTAIR Epigenetically Modulates PTEN Expression via MicroRNA-29b: A Novel Mechanism in Regulation of Liver Fibrosis. -lncRNA target hsa-mir-100 "Carcinoma, Colon" 28130225 "Cellular Model of Colon Cancer Progression Reveals Signatures of mRNAs, miRNA, lncRNAs, and Epigenetic Modifications Associated with Metastasis." -lncRNA target hsa-mir-125b "Carcinoma, Colon" 28130225 "Cellular Model of Colon Cancer Progression Reveals Signatures of mRNAs, miRNA, lncRNAs, and Epigenetic Modifications Associated with Metastasis." -lncRNA target hsa-mir-99a "Carcinoma, Colon" 28130225 "Cellular Model of Colon Cancer Progression Reveals Signatures of mRNAs, miRNA, lncRNAs, and Epigenetic Modifications Associated with Metastasis." -lncRNA target hsa-mir-182 Glioma 28137422 The lncRNA UCA1 interacts with miR-182 to modulate glioma proliferation and migration by targeting iASPP. -lncRNA target hsa-mir-101 "Carcinoma, Lung, Non-Small-Cell" 28147312 Upregulated lncRNA SNHG1 contributes to progression of non-small cell lung cancer through inhibition of miR-101-3p and activation of Wnt/¦Â-catenin signaling pathway. -lncRNA target hsa-mir-34c Inflammatory Bowel Diseases 28153728 MiR-34c and PlncRNA1 mediated the function of intestinal epithelial barrier by regulating tight junction proteins in inflammatory bowel disease. -lncRNA target hsa-mir-200a Colorectal Carcinoma 28164117 The lncRNA H19 Promotes Cell Proliferation by Competitively Binding to miR-200a and Derepressing ¦Â-Catenin Expression in Colorectal Cancer. -lncRNA target hsa-mir-300 "Carcinoma, Bladder" 28178615 Long non-coding RNA TUG1 promotes cell proliferation and metastasis by negatively regulating miR-300 in gallbladder carcinoma. -lncRNA target hsa-mir-200 "Carcinoma, Breast" 28187158 Role of the long non-coding RNA PVT1 in the dysregulation of the ceRNA-ceRNA network in human breast cancer. -lncRNA target hsa-mir-21 Leukemia 28190319 LncRNA MEG3 Regulates Imatinib Resistance in Chronic Myeloid Leukemia via Suppressing MicroRNA-21. -lncRNA target hsa-mir-17 Non-Traumatic Osteonecrosis 28207735 Long non-coding RNA HOTAIR inhibits miR-17-5p to regulate osteogenic differentiation and proliferation in non-traumatic osteonecrosis of femoral head. -lncRNA target hsa-mir-211 "Carcinoma, Colon" 28214867 The Novel Long Noncoding RNA TUSC7 Inhibits Proliferation by Sponging MiR-211 in Colorectal Cancer. -lncRNA target hsa-mir-139 "Carcinoma, Hepatocellular" 28231734 Long non-coding RNA XIST promotes cell growth by regulating miR-139-5p/PDK1/AKT axis in hepatocellular carcinoma. -lncRNA target hsa-mir-214 "Carcinoma, Nasopharyngeal" 28245169 Long Noncoding RNA LINC0086 Functions as a Tumor Suppressor in Nasopharyngeal Carcinoma by Targeting miR-214. -lncRNA target hsa-mir-29b Diabetic Retinopathy 28246353 Long non-coding RNA MIAT acts as a biomarker in diabetic retinopathy by absorbing miR-29b and regulating cell apoptosis. -lncRNA target hsa-mir-449a "Carcinoma, Lung, Non-Small-Cell" 28248928 "The lncRNA XIST exhibits oncogenic properties via regulation of miR-449a and Bcl-2 in human non-small cell lung cancerThis article has been corrected since Advanced Online Publication, and an erratum is also printed in this issue." -lncRNA target hsa-mir-124 "Carcinoma, Tounge" 28260102 Long non-coding RNA MALAT1 interacts with miR-124 and modulates tongue cancer growth by targeting JAG1. -lncRNA target hsa-mir-125b Hepatitis B Virus Infection 28267418 MicroRNA-125b-5p mediates post-transcriptional regulation of hepatitis B virus replication via the LIN28B/let-7 axis. -lncRNA target hsa-mir-203 "Carcinoma, Hepatocellular" 28271214 Long non-coding RNA UCA1 regulates the expression of Snail2 by miR-203 to promote hepatocellular carcinoma progression. -lncRNA target hsa-mir-204 Uterine Corpus Endometrial Carcinoma 28280730 Cancer-Related Triplets of mRNA-lncRNA-miRNA Revealed by Integrative Network in Uterine Corpus Endometrial Carcinoma. -lncRNA target hsa-mir-320 Uterine Corpus Endometrial Carcinoma 28280730 Cancer-Related Triplets of mRNA-lncRNA-miRNA Revealed by Integrative Network in Uterine Corpus Endometrial Carcinoma. -lncRNA target hsa-mir-150 Myocardial Infarction 28295592 Knockdown of Long Non-Coding RNA-ZFAS1 Protects Cardiomyocytes Against Acute Myocardial Infarction Via Anti-Apoptosis by Regulating miR-150/CRP. -lncRNA target hsa-mir-200a Hepatitis C Virus Infection 28302418 LncRNA-ATB/microRNA-200a/¦Â-catenin regulatory axis involved in the progression of HCV-related hepatic fibrosis. -lncRNA target hsa-mir-200b Hepatitis C Virus Infection 28302418 LncRNA-ATB/microRNA-200a/¦Â-catenin regulatory axis involved in the progression of HCV-related hepatic fibrosis. -lncRNA target hsa-mir-24 "Carcinoma, Colon" 28306719 "Chromosome 19q13 disruption alters expressions of CYP2A7, MIA and MIA-RAB4B lncRNA and contributes to FAP-like phenotype in APC mutation-negative familial colorectal cancer patients." -lncRNA target hsa-mir-770 Gastric Cardia Adenocarcinoma 28345805 "Promoter hypermethylation-mediated downregulation of miR-770 and its host gene MEG3, a long non-coding RNA, in the development of gastric cardia adenocarcinoma." -lncRNA target hsa-mir-129 Osteosarcoma 28346809 MALAT1 promotes osteosarcoma development by regulation of HMGB1 via miR-142-3p and miR-129-5p. -lncRNA target hsa-mir-142 Osteosarcoma 28346809 MALAT1 promotes osteosarcoma development by regulation of HMGB1 via miR-142-3p and miR-129-5p. -lncRNA target hsa-mir-181a "Carcinoma, Nasopharyngeal" 28358263 LncRNA CCAT1 modulates the sensitivity of paclitaxel in nasopharynx cancers cells via miR-181a/CPEB2 axis. -lncRNA target hsa-mir-138 "Carcinoma, Colon" 28358427 H19 promotes the migration and invasion of colon cancer by sponging miR-138 to upregulate the expression of HMGA1. -lncRNA target hsa-mir-490 "Carcinoma, Colon" 28381168 Long non-coding RNA colon cancer-associated transcript 1 functions as a competing endogenous RNA to regulate cyclin-dependent kinase 1 expression by sponging miR-490-3p in hepatocellular carcinoma progression. -lncRNA target hsa-mir-145 "Adenocarcinoma, Lung" 28388536 Long noncoding RNA ROR regulates chemoresistance in docetaxel-resistant lung adenocarcinoma cells via epithelial mesenchymal transition pathway. -lncRNA target hsa-mir-199a "Carcinoma, Prostate" 28400279 SNHG1 lncRNA negatively regulates miR-199a-3p to enhance CDK7 expression and promote cell proliferation in prostate cancer. -lncRNA target hsa-mir-200a "Carcinoma, Hepatocellular" 28403886 The long non-coding RNA TP73-AS1 modulates HCC cell proliferation through miR-200a-dependent HMGB1/RAGE regulation. -lncRNA target hsa-mir-26b Melanoma 28409552 Long Noncoding RNA PVT1 Promotes Melanoma Progression via Endogenous Sponging miR-26b. -lncRNA target hsa-mir-153 Osteosarcoma 28411362 Knockdown of Long Noncoding RNA TUG1 Inhibits the Proliferation and Cellular Invasion of Osteosarcoma Cells by Sponging miR-153. -lncRNA target hsa-mir-210 Osteosarcoma 28415557 "lncRNA CTA is an essential regulator in DOX-induced OS cell apoptosis, and the lncRNA CTA-miR-210 axis plays an important role in reducing OS chemoresistance" -lncRNA target hsa-mir-19b Medulloblastoma 28415684 The long noncoding RNA linc-NeD125 controls the expression of medulloblastoma driver genes by microRNA sponge activity. -lncRNA target hsa-mir-372 "Carcinoma, Hepatocellular" 28415780 Long noncoding RNA PCAT-14 induces proliferation and invasion by hepatocellular carcinoma cells by inducing methylation of miR-372. -lncRNA target hsa-mir-21 Glioblastoma 28423669 "The novel long non-coding RNA TALNEC2, regulates tumor cell growth and the stemness and radiation response of glioma stem cells." -lncRNA target hsa-mir-145 "Carcinoma, Oral" 28443494 Expression profiling of long non-coding RNA identifies linc-RoR as a prognostic biomarker in oral cancer. -lncRNA target hsa-mir-186 "Carcinoma, Lung, Non-Small-Cell" 28448993 The Long Non-Coding RNA XIST Controls Non-Small Cell Lung Cancer Proliferation and Invasion by Modulating miR-186-5p. -lncRNA target hsa-mir-495 "Carcinoma, Renal Cell" 28466784 LncRNA UCA1 promotes renal cell carcinoma proliferation through epigenetically repressing p21 expression and negatively regulating miR-495. -lncRNA target hsa-mir-217 "Carcinoma, Colon" 28472810 The Long Non-Coding RNA CRNDE Promotes Colorectal Carcinoma Progression by Competitively Binding miR-217 with TCF7L2 and Enhancing the Wnt/¦Â-Catenin Signaling Pathway. -lncRNA target hsa-mir-200b Melanoma 28487474 "Long noncoding RNA HEIH promotes melanoma cell proliferation, migration and invasion via inhibition of miR-200b/a/429." -lncRNA target hsa-mir-429 Melanoma 28487474 "Long noncoding RNA HEIH promotes melanoma cell proliferation, migration and invasion via inhibition of miR-200b/a/429." -lncRNA target hsa-mir-145 "Carcinoma, Gastric" 28490034 Long Noncoding RNA CRNDE Promotes Proliferation of Gastric Cancer Cells by Targeting miR-145. -lncRNA target hsa-mir-26a Glioblastoma 28499919 Long non-coding RNA AC023115.3 suppresses chemoresistance of glioblastoma by reducing autophagy. -lncRNA target hsa-mir-221 Osteosarcoma 28519068 Long Noncoding RNA GAS5 Suppresses Cell Growth and Epithelial-Mesenchymal Transition in Osteosarcoma by Regulating the miR-221/ARHI Pathway. -lncRNA target hsa-mir-9 "Carcinoma, Hepatocellular" 28520103 Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression. -lncRNA target hsa-mir-21 Cardiac Fibrosis 28526319 LncRNA GAS5 controls cardiac fibroblast activation and fibrosis by targeting miR-21 via PTEN/MMP-2 signaling pathway. -lncRNA target hsa-mir-129 "Carcinoma, Hepatocellular" 28526689 Long non-coding RNA NEAT1 promotes hepatocellular carcinoma cell proliferation through the regulation of miR-129-5p-VCP-I¦ÊB. -lncRNA target hsa-mir-9 "Carcinoma, Esophageal" 28539329 Aberrant Methylation-Mediated Silencing of lncRNA MEG3 Functions as a ceRNA in Esophageal Cancer. -lncRNA target hsa-mir-20a Neoplasms [unspecific] 28542387 LncRNA-AF113014 promotes the expression of Egr2 by interaction with miR-20a to inhibit proliferation of hepatocellular carcinoma cells. -lncRNA target hsa-let-7 Pancreatic Neoplasms 28580169 "linc-ROR functioned as a competing endogenous RNA (ceRNA) to several tumor suppressor microRNAs, particularly some members of let-7 family" -lncRNA target hsa-mir-7 Gastric Neoplasms 28608528 Overexpression of Circular RNA ciRS-7 Abrogates the Tumor Suppressive Effect of miR-7 on Gastric Cancer via PTEN/PI3K/AKT Signaling Pathway. -lncRNA target hsa-mir-335 "Carcinoma, Gastric" 28618927 Long non-coding RNA MSTO2P promotes the proliferation and colony formation in gastric cancer by indirectly regulating miR-335 expression. -lncRNA target hsa-mir-143 Colorectal Carcinoma 28619512 PART-1 functions as a competitive endogenous RNA for promoting tumor progression by sponging miR-143 in colorectal cancer. -lncRNA target hsa-mir-218 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 28631575 Long non-coding RNA CCAT1/miR-218/ZFX axis modulates the progression of laryngeal squamous cell cancer. -lncRNA target hsa-mir-214 "Carcinoma, Pancreatic" 28639886 "A competing endogenous RNA network identifies novel mRNA, miRNA and lncRNA markers for the prognosis of diabetic pancreatic cancer." -lncRNA target hsa-mir-429 "Carcinoma, Pancreatic" 28639886 "A competing endogenous RNA network identifies novel mRNA, miRNA and lncRNA markers for the prognosis of diabetic pancreatic cancer." -lncRNA target hsa-mir-200b "Squamous Cell Carcinoma, Esophageal" 28640252 Long non-coding RNA ATB promotes malignancy of esophageal squamous cell carcinoma by regulating miR-200b/Kindlin-2 axis. -lncRNA target hsa-mir-23b "Carcinoma, Endometrial" 28653877 Long non-coding RNA tumor suppressor candidate 7 advances chemotherapy sensitivity of endometrial carcinoma through targeted silencing of miR-23b. -lncRNA target hsa-mir-150 Lung Injury [unspecific] 28655711 Long noncoding RNA FOXD3-AS1 regulates oxidative stress-induced apoptosis via sponging microRNA-150. -lncRNA target hsa-mir-186 "Carcinoma, Hepatocellular" 28656879 Long non-coding RNA PVT1 serves as a competing endogenous RNA for miR-186-5p to promote the tumorigenesis and metastasis of hepatocellular carcinoma. -lncRNA target hsa-mir-196a "Carcinoma, Cervical" 28671039 LncRNA GAS5 suppresses the tumorigenesis of cervical cancer by downregulating miR-196a and miR-205. -lncRNA target hsa-mir-205 "Carcinoma, Cervical" 28671039 LncRNA GAS5 suppresses the tumorigenesis of cervical cancer by downregulating miR-196a and miR-205. -lncRNA target hsa-mir-17 Atherosclerosis 28676341 "The Circular RNA Interacts with STAT3, Increasing Its Nuclear Translocation and Wound Repair by Modulating Dnmt3a and miR-17 Function." -lncRNA target hsa-let-7 "Leukemia, Myeloid, Acute" 28693523 "LIN28B/let-7/IGF2BP1, in leukemogenesis and provide a rationale to target this pathway as effective therapeutic strategy" -lncRNA target hsa-mir-125b Osteosarcoma 28695772 "Circular RNA GLI2 promotes osteosarcoma cell proliferation, migration, and invasion by targeting miR-125b-5p." -lncRNA target hsa-mir-204 "Carcinoma, Hepatocellular" 28720061 The long non-coding RNA MALAT1 promotes the migration and invasion of hepatocellular carcinoma by sponging miR-204 and releasing SIRT1. -lncRNA target hsa-mir-101 "Carcinoma, Colon" 28720069 Long non-coding RNA SPRY4-IT1 promotes proliferation and invasion by acting as a ceRNA of miR-101-3p in colorectal cancer cells. -lncRNA target hsa-mir-195 "Carcinoma, Hepatocellular" 28722813 Knockdown of long non-coding RNA MALAT1 inhibits growth and motility of human hepatoma cells via modulation of miR-195. -lncRNA target hsa-mir-19a "Carcinoma, Hepatocellular" 28724429 its pro-metastatic phenotype can partially be attributed to the HOXD-AS1/miR19a/ARHGAP11A signaling axis -lncRNA target hsa-mir-134 "Carcinoma, Nasopharyngeal" 28728844 Long non-coding RNA PCAT7 regulates ELF2 signaling through inhibition of miR-134-5p in nasopharyngeal carcinoma. -lncRNA target hsa-mir-19b Breast Neoplasms 28731027 PTENP1 acts as a ceRNA to regulate PTEN by sponging miR-19b and explores the biological role of PTENP1 in breast cancer -lncRNA target hsa-mir-92a Coronary Artery Disease 28760552 CDKN2B-AS may indirectly regulate coronary artery disease-associated genes via targeting miR-92a. -lncRNA target hsa-mir-144 Lung Neoplasms 28762326 Long Noncoding RNA Urothelial Carcinoma Associated 1 Promotes the Proliferation and Metastasis of Human Lung Tumor Cells by Regulating MicroRNA-144. -lncRNA target hsa-mir-29c Osteosarcoma 28789596 WITHDRAWN: Circular RNA hsa_circ_0001564 facilitates tumorigenesis of osteosarcoma via sponging miR-29c-3p. -lncRNA target hsa-mir-21 Multiple Myeloma 28801664 "we identified microRNA-21 as a STAT3 target gene with strong anti-apoptotic potential, suggesting that noncoding RNAs have an impact on the pathogenesis of human multiple myeloma" -lncRNA target hsa-mir-34a Osteosarcoma 28810936 "lncRNA C2dat1 Promotes Cell Proliferation, Migration, and Invasion by Targeting miR-34a-5p in Osteosarcoma Cells." -lncRNA target hsa-mir-205 Neoplasms [unspecific] 28825698 Functionally the lncRNA-PNUTS serves as a competitive sponge for miR-205 during epithelial-mesenchymal transition (EMT) -lncRNA target hsa-mir-150 Myocardial Infarction 28843520 The long non-coding RNA MIAT regulates zinc finger E-box binding homeobox 1 expression by sponging miR-150 and promoteing cell invasion in non-small-cell lung cancer. -lncRNA target hsa-let-7 Neoplasms [unspecific] 28846452 "Concise Review: LIN28/let-7 Signaling, a Critical Double-Negative Feedback Loop During Pluripotency, Reprogramming, and Tumorigenicity." -lncRNA target hsa-mir-106b "Carcinoma, Ovarian" 28864116 lncRNA PCA3 may coordinate EOC tumorigenesis through disrupting miR-106b regulated gene expression -lncRNA target hsa-mir-138 "Carcinoma, Lung, Non-Small-Cell" 28872894 Knockdown of Long Noncoding RNA Small Nucleolar RNA Host Gene 12 Inhibits Cell Growth and Induces Apoptosis by Upregulating miR-138 in Nonsmall Cell Lung Cancer. -lncRNA target hsa-mir-125b "Squamous Cell Carcinoma, Oral" 28926115 Long non-coding RNA MALAT1 promotes oral squamous cell carcinoma development via microRNA-125b/STAT3 axis. -lncRNA target hsa-let-7 "Adenocarcinoma, Pancreatic Ductal" 28947981 "Lin28B, a Lin28 homologue, represses the biogenesis of let-7 microRNAs (miRNAs), has a role in tumorigenesis, and is considered a potential therapeutic target for various human malignancies" -lncRNA target hsa-mir-21 Colon Neoplasms 28954383 Long non-coding RNA CASC7 inhibits the proliferation and migration of colon cancer cells via inhibiting microRNA-21. -lncRNA target hsa-mir-31 Chordoma 28963737 Long non-coding RNA LOC554202 modulates chordoma cell proliferation and invasion by recruiting EZH2 and regulating miR-31 expression. -lncRNA target hsa-mir-124 "Carcinoma, Lung, Non-Small-Cell" 29034803 LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human non-small cell lung cancer cells. -lncRNA target hsa-mir-34a Breast Neoplasms 29037220 circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a. -lncRNA target hsa-mir-124 Cardiovascular Diseases [unspecific] 29042195 Circular RNA WDR77 target FGF-2 to regulate vascular smooth muscle cells proliferation and migration by sponging miR-124. -lncRNA target hsa-mir-34a Gastric Neoplasms 29080815 Knockdown of long non-coding RNA HOTAIR inhibits cisplatin resistance of gastric cancer cells through inhibiting the PI3K/Akt and Wnt/¦Â-catenin signaling pathways by up-regulating miR-34a. -lncRNA target hsa-mir-939 Colorectal Carcinoma 29081216 Long Noncoding RNA HEIH Promotes Colorectal Cancer Tumorigenesis via Counteracting miR-939?Mediated Transcriptional Repression of Bcl-xL. -lncRNA target hsa-mir-200c Lung Fibrosis 29113749 Long non-coding RNA-ATB promotes EMT during silica-induced pulmonary fibrosis by competitively binding miR-200c. -lncRNA target hsa-mir-184 "Squamous Cell Carcinoma, Oral" 29125238 LncRNA UCA1 promotes proliferation and cisplatin resistance of oral squamous cell carcinoma by sunppressing miR-184 expression. -lncRNA target hsa-mir-9 Glioma 29137410 LINC00461 knockdown decreased expression levels of microRNA miR-9 and flanking genes MEF2C and TMEM161B -lncRNA target hsa-mir-195 Wilms Tumor 29159834 LINC00473 as an oncogene is up-regulated to participate into the molecular pathogenesis of Wilms tumour via miR-195/IKK¦Á -lncRNA target hsa-mir-613 "Carcinoma, Lung, Non-Small-Cell" 29187267 Long Noncoding RNA (lncRNA) HOTAIR Affects Tumorigenesis and Metastasis of Non-Small Cell Lung Cancer by Upregulating miR-613. -lncRNA target hsa-mir-215 Colorectal Carcinoma 29187907 Long non-coding RNA UICLM promotes colorectal cancer liver metastasis by acting as a ceRNA for microRNA-215 to regulate ZEB2 expression -lncRNA target hsa-mir-34a Cervical Neoplasms 29218240 "The long noncoding RNA LINC00473, a target of microRNA 34a, promotes tumorigenesis by inhibiting ILF2 degradation in cervical cancer" -lncRNA target hsa-mir-32 Pancreatic Neoplasms 29225772 Long non-coding RNA GAS5 suppresses pancreatic cancer metastasis through modulating miR-32-5p/PTEN axis -lncRNA target hsa-mir-125b Sepsis 29227823 "MALAT1 aggravates cardiac inflammation and dysfunction in sepsis, which is achieved via interaction with miR-125b and p38 MAPK/NF¦ÊB" -lncRNA target hsa-mir-21 "Stroke, Ischemic" 29238035 "our data uncovers a novel mechanism of lncRNA MEG3 as a ceRNA by targeting miR-21/PDCD4 signaling pathway in regulating ischemic neuronal death, which may help develop new strategies for the therapeutic interventions in cerebral ischemic stroke" -lncRNA target hsa-mir-373 Glioma 29310118 Long Non-Coding RNA HOXA-AS2 Regulates Malignant Glioma Behaviors and Vasculogenic Mimicry Formation via the MiR-373/EGFR Axis -lncRNA target hsa-mir-21 Osteosarcoma 29323740 "Long non-coding RNA ASBEL promotes osteosarcoma cell proliferation, migration and invasion by regulating microRNA-21" -lncRNA target hsa-mir-27a Diabetic Nephropathy 29334763 Long Noncoding RNA LINC01619 Regulates MicroRNA-27a/Forkhead Box Protein O1 and Endoplasmic Reticulum Stress-Mediated Podocyte Injury in Diabetic Nephropathy -lncRNA target hsa-let-7a "Squamous Cell Carcinoma, Esophageal" 29393461 Lin28/microRNA-let-7a promotes metastasis under circumstances of hyperactive Wnt signaling in esophageal squamous cell carcinoma -lncRNA target hsa-mir-10a Glioblastoma 29397407 Long non-coding RNA TUSC7 inhibits temozolomide resistance by targeting miR-10a in glioblastoma -lncRNA target hsa-mir-196a Lung Fibrosis 29411215 The lncRNA H19 Mediates Pulmonary Fibrosis by Regulating the miR-196a/COL1A1 Axis. -lncRNA target hsa-mir-124 Glioma 29412778 TP73-AS1 was specificallyupregulated in brain glioma cell lines and promoted glioma cell growth through targeting miR-124TP73-AS1 was specifically upregulated in brain glioma cell lines and promoted glioma cell growth through targeting miR-124 -lncRNA target hsa-mir-23a Hypoxic-Ischemic Encephalopathy 29428721 GAS5 regulated hippocampal neuron function by sponging miR-23a -lncRNA target hsa-mir-18a Prostate Neoplasms 29465000 Long non-coding RNA FENDRR reduces prostate cancer malignancy by competitively binding miR-18a-5p with RUNX1. -lncRNA target hsa-mir-145 "Carcinoma, Lung, Non-Small-Cell" 29466052 Long noncoding RNA SNHG1 promotes non-small cell lung cancer progression by up-regulating MTDH via sponging miR-145-5p. -lncRNA target hsa-mir-101 Glioblastoma 29479863 Long noncoding RNA MALAT1 knockdown reverses chemoresistance to temozolomide via promoting microRNA-101 in glioblastoma -lncRNA target hsa-mir-21 "Carcinoma, Lung" 29503447 "We found that LIN28B overexpression significantly increased the number of CD44+/CD326+ tumor cells, upregulated VEGF-A and miR-21 and promoted tumor angiogenesis and epithelial-to-mesenchymal transition (EMT) accompanied by enhanced AKT phosphorylation and nuclear translocation of c-MYC" -lncRNA target hsa-mir-181a "Carcinoma, Skin" 29514220 Long non-coding RNA CASC2 inhibits tumorigenesis via the miR-181a/PLXNC1 axis in melanoma. -lncRNA target hsa-mir-145 "Carcinoma, Hepatocellular" 29559320 Long non-coding RNA ROR promotes radioresistance in hepatocelluar carcinoma cells by acting as a ceRNA for microRNA-145 to regulate RAD18 expression -lncRNA target hsa-mir-503 Prostate Neoplasms 29571017 Long noncoding RNA SNHG7 accelerates prostate cancer proliferation and cycle progression through cyclin D1 by sponging miR-503. -lncRNA target hsa-mir-513c "Carcinoma, Hepatocellular" 29574975 "LncRNA FLVCR1-AS1 acts as miR-513c sponge to modulate cancer cell proliferation, migration, and invasion in hepatocellular carcinoma." -lncRNA target hsa-mir-140 "Carcinoma, Cervical" 29604594 LncRNA SNHG20 promotes cell proliferation and invasion via miR-140-5p-ADAM10 axis in cervical cancer. -lncRNA target hsa-mir-26b "Carcinoma, Breast" 29620147 lncRNA PVT1 promotes the angiogenesis of vascular endothelial cell by targeting miR?26b to activate CTGF/ANGPT2. -lncRNA target hsa-mir-5095 Cholangiocarcinoma 29620172 Long noncoding RNA LINC01296 promotes tumor growth and progression by sponging miR-5095 in human cholangiocarcinoma. -lncRNA target hsa-let-7 "Colitis, Ulcerative" 29621481 "H19 lncRNA bound to p53 and microRNAs that inhibit cell proliferation, including microRNA 34a and let-7; H19 lncRNA binding blocked their function, leading to increased expression of genes that promote regeneration of the epithelium" -lncRNA target hsa-mir-125a Oral Neoplasms 29635126 The role of long non-coding RNA ANRIL in the carcinogenesis of oral cancer by targeting miR-125a. -lncRNA target hsa-mir-758 "Carcinoma, Lung, Non-Small-Cell" 29635134 The long non-coding RNA-DANCR exerts oncogenic functions in non-small cell lung cancer via miR-758-3p. -lncRNA target hsa-mir-329 "Carcinoma, Bladder" 29653362 The long noncoding RNA ZFAS1 facilitates bladder cancer tumorigenesis by sponging miR-329. -lncRNA target hsa-mir-34c Osteosarcoma 29654165 Knockdown of the oncogene LncRNA NEAT1 restores the availability of miR-34c and improves the sensitivity to cisplatin in osteosarcoma -lncRNA target hsa-mir-182 Glioblastoma 29655792 Long non-coding RNA UCA1/miR-182/PFKFB2 axis modulates glioblastoma-associated stromal cells-mediated glycolysis and invasion of glioma cells. -lncRNA target hsa-mir-125a "Leukemia, Myeloid, Acute" 29663500 Knockdown of LncRNA-UCA1 suppresses chemoresistance of pediatric AML by inhibiting glycolysis through the microRNA-125a/hexokinase 2 pathway -lncRNA target hsa-mir-204 Acute Kidney Failure 29669307 Long non-coding RNA NEAT1 plays an important role in sepsis-induced acute kidney injury by targeting miR-204 and modulating the NF-¦ÊB pathway -lncRNA target hsa-mir-100 Pneumonia 29673591 Long noncoding RNA HAGLROS regulates cell apoptosis and autophagy in lipopolysaccharides-induced WI-38?cells via modulating miR-100/NF-¦ÊB axis. -lncRNA target hsa-mir-143 "Carcinoma, Bladder" 29674277 Long noncoding RNA FOXD2-AS1 accelerates the gemcitabine-resistance of bladder cancer by sponging miR-143. -lncRNA target hsa-mir-1253 Osteosarcoma 29678578 Circular RNA circNASP modulates the malignant behaviors in osteosarcoma via miR-1253/FOXF1 pathway. -lncRNA target hsa-mir-34a Colon Neoplasms 29679755 Long non-coding RNA XIST sponges miR-34a to promotes colon cancer progression via Wnt/¦Â-catenin signaling pathway. -lncRNA target hsa-mir-125a "Carcinoma, Hepatocellular" 29689270 Mutual suppression of miR-125a and Lin28b in human hepatocellular carcinoma cells. -lncRNA target hsa-mir-145 Colon Neoplasms 29690669 "LincRNA-ROR functions as a ceRNA to regulate Oct4, Sox2, and Nanog expression by sponging miR-145 and its effect on biologic characteristics of colonic cancer stem cells" -lncRNA target hsa-mir-4302 Lung Neoplasms 29698681 Circular RNA hsa_circRNA_103809 promotes lung cancer progression via facilitating ZNF121-dependent MYC expression by sequestering miR-4302. -lncRNA target hsa-mir-142 "Diabetes Mellitus, Type 2" 29704494 "Metformin, a first-line drug for type 2 diabetes mellitus, disrupts the MALAT1/miR-142-3p sponge to decrease invasion and migration in cervical cancer cells." -lncRNA target hsa-let-7 Neoplasms [unspecific] 29724816 Modulation of LIN28B/Let-7 Signaling by Propranolol Contributes to Infantile Hemangioma Involution. -lncRNA target hsa-mir-124 Invasive Bladder Transitional Cell Carcinoma 29736319 LncRNA MALAT1 promotes tumor growth and metastasis by targeting miR-124/foxq1 in bladder transitional cell carcinoma (BTCC). -lncRNA target hsa-mir-185 Colorectal Carcinoma 29737580 Long non-coding RNA FOXD2-AS1 contributes to colorectal?cancer proliferation through its interaction with?microRNA-185-5p. -lncRNA target hsa-mir-148a Prostate Neoplasms 29749452 MEF2?activated long non?coding RNA PCGEM1 promotes cell proliferation in hormone?refractory prostate cancer through downregulation of miR?148a. -lncRNA target hsa-mir-204 "Carcinoma, Pancreatic" 29753015 LncRNA ZEB2-AS1 promotes pancreatic cancer cell growth and invasion through regulating the miR-204/HMGB1 axis. -lncRNA target hsa-mir-30a Gastric Neoplasms 29761936 upregulated expression of linc00483 in gastric cancer acts as a sponge to absorb endogenous tumour suppressor miR-30a-3p -lncRNA target hsa-mir-30b Osteosarcoma 29772430 "LncRNA DICER1-AS1 promotes the proliferation, invasion and autophagy of osteosarcoma cells via miR-30b/ATG5." -lncRNA target hsa-mir-133 "Carcinoma, Pancreatic" 29772434 The interaction of long non-coding RNA MIAT and miR-133 play a role in the proliferation and metastasis of pancreatic carcinoma. -lncRNA target hsa-mir-21 "Leukemia, Myeloid, Chronic" 29772439 Long noncoding RNA MEG3 inhibits proliferation of chronic myeloid leukemia cells by sponging microRNA21. -lncRNA target hsa-mir-369 Colorectal Carcinoma 29773344 LncRNA OIP5-AS1 regulates radioresistance by targeting DYRK1A through miR-369-3p in colorectal cancer cells. -lncRNA target hsa-mir-141 "Carcinoma, Endometrial" 29775889 LncRNA MIR22HG negatively regulates miR-141-3p to enhance DAPK1 expression and inhibits endometrial carcinoma cells proliferation. -lncRNA target hsa-mir-23b "Carcinoma, Hepatocellular" 29778425 LncRNA HOTAIR contributes to the malignancy of hepatocellular carcinoma by enhancing epithelial-mesenchymal transition via sponging miR-23b-3p from ZEB1. -lncRNA target hsa-mir-150 Hypertrophy 29786749 Long noncoding RNA myocardial infarction?associated transcript is associated with the microRNA?150?5p/P300 pathway in cardiac hypertrophy. -lncRNA target hsa-mir-138 "Carcinoma, Renal Cell" 29789714 Estrogen receptor ¦Â promotes renal cell carcinoma progression via regulating LncRNA HOTAIR-miR-138/200c/204/217 associated CeRNA network. -lncRNA target hsa-mir-200c "Carcinoma, Renal Cell" 29789714 Estrogen receptor ¦Â promotes renal cell carcinoma progression via regulating LncRNA HOTAIR-miR-138/200c/204/217 associated CeRNA network. -lncRNA target hsa-mir-204 "Carcinoma, Renal Cell" 29789714 Estrogen receptor ¦Â promotes renal cell carcinoma progression via regulating LncRNA HOTAIR-miR-138/200c/204/217 associated CeRNA network. -lncRNA target hsa-mir-217 "Carcinoma, Renal Cell" 29789714 Estrogen receptor ¦Â promotes renal cell carcinoma progression via regulating LncRNA HOTAIR-miR-138/200c/204/217 associated CeRNA network. -lncRNA target hsa-mir-382 Ovarian Neoplasms 29790629 Long non-coding RNA NEAT1 promoted ovarian cancer cells' metastasis through regulation of miR-382-3p/ROCK1 axial. -lncRNA target hsa-mir-873 Lung Neoplasms 29790668 The effects of aberrant expression of LncRNA DGCR5/miR-873-5p/TUSC3 in lung cancer cell progression. -lncRNA target hsa-mir-196a "Carcinoma, Breast, Triple Negative" 29793177 Long noncoding RNA GAS5 suppresses triple negative breast cancer progression through inhibition of proliferation and invasion by competitively binding miR-196a-5p. -lncRNA target hsa-let-7b Epilepsy 29795132 Long non-coding RNA H19 contributes to apoptosis of hippocampal neurons by inhibiting let-7b in a rat model of temporal lobe epilepsy. -lncRNA target hsa-mir-223 Lupus Nephritis 29800915 Long non-coding RNA TUG1 protects renal tubular epithelial cells against injury induced by lipopolysaccharide via regulating microRNA-223. -lncRNA target hsa-mir-30a "Carcinoma, Thyroid, Papillary" 29803929 Long noncoding RNA PVT1 enhances the viability and invasion of papillary thyroid carcinoma cells by functioning as ceRNA of microRNA-30a through mediating expression of insulin like growth factor 1 receptor. -lncRNA target hsa-mir-449a "Carcinoma, Lung, Non-Small-Cell" 29803931 Long noncoding RNA TP73-AS1 promotes non-small cell lung cancer progression by competitively sponging miR-449a/EZH2. -lncRNA target hsa-mir-9 "Carcinoma, Lung, Non-Small-Cell" 29805671 "Regulatory interactions between long noncoding RNA LINC00968 and miR-9-3p in non-small cell lung cancer: A bioinformatic analysis based on miRNA microarray, GEO and TCGA." -lncRNA target hsa-mir-29a Colorectal Carcinoma 29807108 Functional role of a long non-coding RNA LIFR-AS1/miR-29a/TNFAIP3 axis in colorectal cancer resistance to pohotodynamic therapy. -lncRNA target hsa-mir-137 "Carcinoma, Lung, Non-Small-Cell" 29812958 Knockdown of LncRNA-XIST Suppresses Proliferation and TGF-¦Â1-Induced EMT in NSCLC Through the Notch-1 Pathway by Regulation of miR-137. -lncRNA target hsa-mir-129 Lung Neoplasms 29857296 "LncRNA NNT-AS1 promotes the proliferation, and invasion of lung cancer cells via regulating miR-129-5p expression." -lncRNA target hsa-mir-142 Osteosarcoma 29864904 Knockdown of long non-coding RNA TP73-AS1 inhibits osteosarcoma cell proliferation and invasion through sponging miR-142. -lncRNA target hsa-mir-124 Myocardial Infarction 29864957 TUG1 alleviates hypoxia injury by targeting miR-124 in H9c2 cells. -lncRNA target hsa-mir-610 Multiple Myeloma 29864963 Long non-coding RNA FEZF1-AS1 promotes cell growth in multiple myeloma via miR-610/Akt3 axis. -lncRNA target hsa-mir-211 "Carcinoma, Ovarian" 29874124 miR-211 sponges lncRNA MALAT1 to suppress tumor growth and progression through inhibiting PHF19 in ovarian carcinoma. -lncRNA target hsa-mir-137 "Carcinoma, Renal Cell" 29874202 Long Noncoding RNA Small Nucleolar RNA Host Gene 1 (SNHG1) Promotes Renal Cell Carcinoma Progression and Metastasis by Negatively Regulating miR-137. -lncRNA target hsa-mir-6873 Chronic Hepatitis B 29888838 regression analysis of gene expression revealed a strong positive correlation between hsa_circ_0000650 and TGF¦Â2 and a negative correlation between hsa_circ_0000650 and miR-6873-3p -lncRNA target hsa-mir-30 Cardiac Fibrosis 29889825 Long Noncoding RNA (lncRNA) n379519 Promotes Cardiac Fibrosis in Post-Infarct Myocardium by Targeting miR-30. -lncRNA target hsa-mir-1245 Lung Neoplasms 29891014 Hsa_circ_0046264 up-regulated BRCA2 to suppress lung cancer through targeting hsa-miR-1245. -lncRNA target hsa-mir-4695 Osteosarcoma 29901121 Long noncoding RNA AFAP1?AS1 enhances cell proliferation and invasion in osteosarcoma through regulating miR?4695?5p/TCF4?¦Â?catenin signaling. -lncRNA target hsa-mir-122 Metabolic Syndrome 29922126 "Those include the HOTAIR and MIAT lncRNAs and their targets, such as miR-122, -150, -155, -182, -197, -375, -608 and HLA-DRA" -lncRNA target hsa-mir-150 Metabolic Syndrome 29922126 "Those include the HOTAIR and MIAT lncRNAs and their targets, such as miR-122, -150, -155, -182, -197, -375, -608 and HLA-DRA" -lncRNA target hsa-mir-155 Metabolic Syndrome 29922126 "Those include the HOTAIR and MIAT lncRNAs and their targets, such as miR-122, -150, -155, -182, -197, -375, -608 and HLA-DRA" -lncRNA target hsa-mir-182 Metabolic Syndrome 29922126 "Those include the HOTAIR and MIAT lncRNAs and their targets, such as miR-122, -150, -155, -182, -197, -375, -608 and HLA-DRA" -lncRNA target hsa-mir-197 Metabolic Syndrome 29922126 "Those include the HOTAIR and MIAT lncRNAs and their targets, such as miR-122, -150, -155, -182, -197, -375, -608 and HLA-DRA" -lncRNA target hsa-mir-375 Metabolic Syndrome 29922126 "Those include the HOTAIR and MIAT lncRNAs and their targets, such as miR-122, -150, -155, -182, -197, -375, -608 and HLA-DRA" -lncRNA target hsa-mir-608 Metabolic Syndrome 29922126 "Those include the HOTAIR and MIAT lncRNAs and their targets, such as miR-122, -150, -155, -182, -197, -375, -608 and HLA-DRA" -lncRNA target hsa-mir-21 Colorectal Carcinoma 29928882 CircRNA circ_0026344 as a prognostic biomarker suppresses colorectal cancer progression via microRNA-21 and microRNA-31. -lncRNA target hsa-mir-31 Colorectal Carcinoma 29928882 CircRNA circ_0026344 as a prognostic biomarker suppresses colorectal cancer progression via microRNA-21 and microRNA-31. -lncRNA target hsa-mir-378a "Carcinoma, Pancreatic" 29930719 this circRNA was most likely to regulate the expression of miR-378a-3p -lncRNA target hsa-mir-375 "Adenocarcinoma, Lung" 29932500 "We built a network of hsa_circ_0000792-targeted miRNA gene interactions, including miR-375 and the corresponding messenger RNAs" -lncRNA target hsa-mir-324 Alzheimer Disease 29956723 Regulatory effects of the long non?coding RNA RP11?543N12.1 and microRNA?324?3p axis on the neuronal apoptosis induced by the inflammatory reactions of microglia. -lncRNA target hsa-mir-4310 Colon Neoplasms 29956772 LncRNA CASC15 promotes colon cancer cell proliferation and metastasis by regulating the miR?4310/LGR5/Wnt/¦Â?catenin signaling pathway. -lncRNA target hsa-mir-125b Sepsis 29962507 "Expression of the Long Intergenic Non-Coding RNA (lincRNA) of the NED25 Gene Modulates the microRNA-125b, STAT3, Nitric Oxide, and Procalcitonin Signaling Pathways in Patients with Sepsis." -lncRNA target hsa-mir-5003 Gastric Neoplasms 29991048 Long Non-Coding RNA RP11-789C1.1 Suppresses Epithelial to Mesenchymal Transition in Gastric Cancer Through the RP11-789C1.1/MiR-5003/E-Cadherin Axis. -lncRNA target hsa-mir-199a "Carcinoma, Breast" 30001527 Linc00518 Contributes to Multidrug Resistance Through Regulating the MiR-199a/MRP1 Axis in Breast Cancer. -lncRNA target hsa-mir-23a "Carcinoma, Breast" 30007957 Effect of the LncRNA GAS5-MiR-23a-ATG3 Axis in Regulating Autophagy in Patients with Breast Cancer. -lncRNA target hsa-mir-518d "Carcinoma, Cervical" 30007986 "CircRNA8924 Promotes Cervical Cancer Cell Proliferation, Migration and Invasion by Competitively Binding to MiR-518d-5p /519-5p Family and Modulating the Expression of CBX8." -lncRNA target hsa-mir-519 "Carcinoma, Cervical" 30007986 "CircRNA8924 Promotes Cervical Cancer Cell Proliferation, Migration and Invasion by Competitively Binding to MiR-518d-5p /519-5p Family and Modulating the Expression of CBX8." -lncRNA target hsa-mir-874 Sepsis 30021355 LncRNA H19 functions as an Aquaporin 1 competitive endogenous RNA to regulate microRNA-874 expression in LPS sepsis. -lncRNA target hsa-mir-182 "Carcinoma, Thyroid" 30021359 LncRNA MEG3 enhances 131I sensitivity in thyroid carcinoma via sponging miR-182. -lncRNA target hsa-mir-193a "Adenocarcinoma, Lung" 30036873 The LncRNA NEAT1 Accelerates Lung Adenocarcinoma Deterioration and Binds to Mir-193a-3p as a Competitive Endogenous RNA. -lncRNA target hsa-mir-203 Ischemia-Reperfusion Injury 30041794 LncRNA MALAT1 sponges miR-203 to promote inflammation in myocardial ischemia-reperfusion injury. -lncRNA target hsa-mir-302 Pituitary Neoplasms 30048990 Lnc-SNHG1 Activates the TGFBR2/SMAD3 and RAB11A/Wnt/¦Â-Catenin Pathway by Sponging MiR-302/372/373/520 in Invasive Pituitary Tumors. -lncRNA target hsa-mir-372 Pituitary Neoplasms 30048990 Lnc-SNHG1 Activates the TGFBR2/SMAD3 and RAB11A/Wnt/¦Â-Catenin Pathway by Sponging MiR-302/372/373/520 in Invasive Pituitary Tumors. -lncRNA target hsa-mir-373 Pituitary Neoplasms 30048990 Lnc-SNHG1 Activates the TGFBR2/SMAD3 and RAB11A/Wnt/¦Â-Catenin Pathway by Sponging MiR-302/372/373/520 in Invasive Pituitary Tumors. -lncRNA target hsa-mir-520 Pituitary Neoplasms 30048990 Lnc-SNHG1 Activates the TGFBR2/SMAD3 and RAB11A/Wnt/¦Â-Catenin Pathway by Sponging MiR-302/372/373/520 in Invasive Pituitary Tumors. -lncRNA target hsa-mir-132 Glioma 30053878 Knockdown of long non-coding RNA NEAT1 inhibits c cell migration and invasion via modulation of SOX2 targeted by miR-132. -lncRNA target hsa-mir-637 Hirschsprung Disease 30062828 Long non-coding RNA FAL1 functions as a ceRNA to antagonize the effect of miR-637 on the down-regulation of AKT1 in Hirschsprung's disease. -lncRNA target hsa-mir-124 "Squamous Cell Carcinoma, Oral" 30078268 Circular RNA circHIPK3 acts as the sponge of microRNA-124 to promote human oral squamous cell carcinoma cells proliferation -lncRNA target hsa-mir-155 "Carcinoma, Hepatocellular" 30091314 XIST Induced by JPX Suppresses Hepatocellular Carcinoma by Sponging miR-155-5p. -lncRNA target hsa-mir-219a Osteosarcoma 30099814 "TUG1 accelerated osteosarcoma proliferation, migration, and invasion by competitively sponging miR-219a-5p, leading to upregulation of Phosphatidylinositol-4, 5-Bisphosphate 3-Kinase Catalytic Subunit Alpha and activation of the protein kinase B (AKT) signaling pathway" -lncRNA target hsa-mir-454 "Adenocarcinoma, Lung" 30099826 LncRNA HOXA11-AS drives cisplatin resistance of human LUAD cells via modulating miR-454-3p/Stat3. -lncRNA target hsa-mir-126 Melanoma 30104884 LINC00888 promoted tumorigenicity of melanoma via miR-126/CRK signaling axis. -lncRNA target hsa-mir-140 Multiple Myeloma 30121664 Knockdown of Linc00515 Inhibits Multiple Myeloma Autophagy and Chemoresistance by Upregulating miR-140-5p and Downregulating ATG14. -lncRNA target hsa-mir-15a Colorectal Carcinoma 30126852 LINC00473 promotes the Taxol resistance via miR-15a in colorectal cancer. -lncRNA target hsa-mir-22 Sepsis 30130540 LncRNA HOX transcript antisense RNA accelerated kidney injury induced by urine-derived sepsis through the miR-22/high mobility group box 1 pathway. -lncRNA target hsa-mir-181a Multiple Myeloma 30134227 Long Non-Coding RNA MEG3 Functions as a Competing Endogenous RNA to Regulate HOXA11 Expression by Sponging miR-181a in Multiple Myeloma. -lncRNA target hsa-mir-593 "Carcinoma, Breast" 30139516 Downregulation of hsa_circ_0007534 suppresses breast cancer cell proliferation and invasion by targeting miR-593/MUC19 signal pathway. -lncRNA target hsa-mir-185 Melanoma 30144501 Long non-coding RNA UCA1 targets miR-185-5p and regulates cell mobility by affecting epithelial-mesenchymal transition in melanoma via Wnt/¦Â-catenin signaling pathway. -lncRNA target hsa-mir-134 Atherosclerosis 30158376 LncRNA DIGIT Accelerates Tube Formation of Vascular Endothelial Cells by Sponging miR-134. -lncRNA target hsa-mir-120 Thrombosis 30171660 "LncRNA WTAPP1 promotes migration and angiogenesis of endothelial progenitor cells via MMP1 through microRNA 3,120 and Akt/PI3K/autophagy pathways." -lncRNA target hsa-mir-3 Thrombosis 30171660 "LncRNA WTAPP1 promotes migration and angiogenesis of endothelial progenitor cells via MMP1 through microRNA 3,120 and Akt/PI3K/autophagy pathways." -lncRNA target hsa-mir-214 Glioma 30179681 LncRNA LOC728196/miR-513c axis facilitates glioma carcinogenesis by targeting TCF7. -lncRNA target hsa-mir-136 Neuropathic Pain 30203524 LINC00657 expedites neuropathic pain development by modulating miR-136/ZEB1 axis in a rat model. -lncRNA target hsa-mir-26a Gastric Neoplasms 30205370 miR-26a/HOXC9 Dysregulation Promotes Metastasis and Stem Cell-Like Phenotype of Gastric Cancer. -lncRNA target hsa-mir-206 Ovarian Neoplasms 30205383 LncRNA HOTAIR Regulates CCND1 and CCND2 Expression by Sponging miR-206 in Ovarian Cancer. -lncRNA target hsa-mir-331 "Carcinoma, Cervical" 30207103 LncRNA XLOC_006390 facilitates cervical cancer tumorigenesis and metastasis as a ceRNA against miR-331-3p and miR-338-3p. -lncRNA target hsa-mir-338 "Carcinoma, Cervical" 30207103 LncRNA XLOC_006390 facilitates cervical cancer tumorigenesis and metastasis as a ceRNA against miR-331-3p and miR-338-3p. -lncRNA target hsa-mir-214 Ovarian Neoplasms 30207107 Upregulation of long non-coding RNA XIST has anticancer effects on epithelial ovarian cancer cells through inverse downregulation of hsa-miR-214-3p. -lncRNA target hsa-mir-143 "Carcinoma, Salivary Adenoid Cystic" 30217729 ADAMTS9-AS2 promotes migration and invasion in SACC by competing with miR-143-3p -lncRNA target hsa-mir-107 "Carcinoma, Cervical" 30231238 lncRNA DLG1-AS1 Promotes Cell Proliferation by Competitively Binding with miR-107 and Up-Regulating ZHX1 Expression in Cervical Cancer. -lncRNA target hsa-mir-1207 Nasopharyngeal Neoplasms 30243935 Long non-coding RNA 319 facilitates nasopharyngeal carcinoma carcinogenesis through regulation of miR-1207-5p/KLF12 axis. -lncRNA target hsa-mir-671 "Carcinoma, Hepatocellular" 30250300 Hypoxia-induced TUFT1 promotes the growth and metastasis of hepatocellular carcinoma by activating the Ca2+/PI3K/AKT pathway. -lncRNA target hsa-mir-451 Osteoarthritis 30272288 LncRNA?p21 promotes chondrocyte apoptosis in osteoarthritis by acting as a sponge for miR?451. -lncRNA target hsa-mir-144 "Carcinoma, Renal Cell, Clear-Cell" 30278113 Construction and comprehensive analysis of dysregulated long non-coding RNA-associated competing endogenous RNA network in clear cell renal cell carcinoma. -lncRNA target hsa-mir-155 "Carcinoma, Renal Cell, Clear-Cell" 30278113 Construction and comprehensive analysis of dysregulated long non-coding RNA-associated competing endogenous RNA network in clear cell renal cell carcinoma. -lncRNA target hsa-mir-21 "Carcinoma, Renal Cell, Clear-Cell" 30278113 Construction and comprehensive analysis of dysregulated long non-coding RNA-associated competing endogenous RNA network in clear cell renal cell carcinoma. -lncRNA target hsa-mir-30a "Carcinoma, Hepatocellular" 30278452 Long Non-Coding MALAT1 Functions as a Competing Endogenous RNA to Regulate Vimentin Expression by Sponging miR-30a-5p in Hepatocellular Carcinoma. -lncRNA target hsa-mir-130a Glioma 30282068 H19 Functions as a Competing Endogenous RNA to Regulate EMT by Sponging miR-130a-3p in Glioma. -lncRNA target hsa-mir-182 "Carcinoma, Bladder" 30285878 Circular RNA BCRC-3 suppresses bladder cancer proliferation through miR-182-5p/p27 axis. -lncRNA target hsa-mir-675 Cataract 30286462 H19 regulates HLECs function through miR-675-mediated CRYAA expression. This finding would provide a novel insight into the pathogenesis of nuclear ARC -lncRNA target hsa-mir-34a Neoplasms [unspecific] 30289954 Dual biomarkers long non-coding RNA GAS5 and microRNA-34a co-expression signature in common solid tumors. -lncRNA target hsa-mir-330 Cardiovascular Diseases [unspecific] 30297107 The long noncoding RNA XIST protects cardiomyocyte hypertrophy by targeting miR-330-3p. -lncRNA target hsa-mir-154 Neuropathic Pain 30335888 LncRNA X inactive specific transcript contributes to neuropathic pain development by sponging miR-154-5p via inducing toll-like receptor 5 in CCI rat models. -lncRNA target hsa-mir-20b Ischemia-Reperfusion Injury 30367982 Long noncoding RNA HOTAIR regulates autophagy via the miR-20b-5p/ATG7 axis in hepatic ischemia/reperfusion injury. -lncRNA target hsa-mir-129 Neoplasms [unspecific] 30374364 "NEAT1 functions as a scaffold RNA molecule by interacting with EZH2 (a subunit of the polycomb repressive complex) to influence the expression of downstream effectors of EZH2, it also acts as a microRNA (miRNA) sponge to suppress the interactions between miRNAs and target mRNAs, and affects the expression of miR-129 by promoting the DNA methylation of the miR-129 promoter region" -lncRNA target hsa-mir-153 Intervertebral Disc Degeneration 30378116 LINC00641 regulates autophagy and intervertebral disc degeneration by acting as a competitive endogenous RNA of miR-153-3p under nutrition deprivation stress. -target gene hsa-let-7a-1 Lung Neoplasms 15172979 decreased abundance; negatively regulate the RAS gene. -target gene hsa-let-7a-2 Lung Neoplasms 15172979 decreased abundance; negatively regulate the RAS gene. -target gene hsa-let-7a-3 Lung Neoplasms 15172979 decreased abundance; negatively regulate the RAS gene. -target gene hsa-let-7b Lung Neoplasms 15172979 decreased abundance; negatively regulate the RAS gene. -target gene hsa-let-7c Lung Neoplasms 15172979 decreased abundance; negatively regulate the RAS gene. -target gene hsa-let-7d Lung Neoplasms 15172979 decreased abundance; negatively regulate the RAS gene. -target gene hsa-let-7e Lung Neoplasms 15172979 decreased abundance; negatively regulate the RAS gene. -target gene hsa-let-7f-1 Lung Neoplasms 15172979 decreased abundance; negatively regulate the RAS gene. -target gene hsa-let-7f-2 Lung Neoplasms 15172979 decreased abundance; negatively regulate the RAS gene. -target gene hsa-let-7g Lung Neoplasms 15172979 decreased abundance; negatively regulate the RAS gene. -target gene hsa-let-7i Lung Neoplasms 15172979 decreased abundance; negatively regulate the RAS gene. -target gene hsa-mir-143 Obesity 16195701 "Modified oligonucleotide complementary to miR-143 effectively suppressed adipocyte differentiation by modulation of its putative target ERK5, a protein previously known to be implicated in MAP kinase signaling pathways." -target gene hsa-mir-372 Testicular Neoplasms 16564011 A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. -target gene hsa-mir-373 Testicular Neoplasms 16564011 A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. -target gene hsa-mir-122 "Carcinoma, Hepatocellular" 16777601 inhibite CAT-1 -target gene hsa-mir-155 Gastrointestinal Neoplasms 16875667 "Therefore, we concluded that artificial miRNA can depress the expression of PRL-3, and that PRL-3 might be a potential therapeutic target for gastric cancer peritoneal metastasis." -target gene hsa-mir-20a Breast Neoplasms 17011485 "TGF-b-2 receptor is expressed in the epithelium of breast cancer and can be regulated by miR-20a, which is down- regulated in breast cancer." -target gene hsa-mir-127 Neoplasms [unspecific] 17012848 "For example, mir-127, which is generally expressed in normal cells but absent in cancer cells, was markedly induced after treatment. Intriguingly, a predicted target of mir-127, BCL6, was translationally downregulated after treatment." -target gene hsa-mir-146a Thyroid Neoplasms 17012848 "Mir-221, mir-22 and mir-146 are significantly upregulated in this disease, whereas the expression of their predicted target gene KIT is lost, concurrently with the miRNA upregulation." -target gene hsa-mir-146b Thyroid Neoplasms 17012848 "Mir-221, mir-22 and mir-146 are significantly upregulated in this disease, whereas the expression of their predicted target gene KIT is lost, concurrently with the miRNA upregulation." -target gene hsa-mir-22 Thyroid Neoplasms 17012848 "Mir-221, mir-22 and mir-146 are significantly upregulated in this disease, whereas the expression of their predicted target gene KIT is lost, concurrently with the miRNA upregulation." -target gene hsa-mir-221 Thyroid Neoplasms 17012848 "Mir-221, mir-22 and mir-146 are significantly upregulated in this disease, whereas the expression of their predicted target gene KIT is lost, concurrently with the miRNA upregulation." -target gene hsa-mir-19a "Carcinoma, Hepatocellular" 17188425 miRNA-19a/b activates PI3K by blocking expression of the tumor suppressor PTEN. -target gene hsa-mir-19b-1 "Carcinoma, Hepatocellular" 17188425 miRNA-19a/b activates PI3K by blocking expression of the tumor suppressor PTEN. -target gene hsa-mir-19b-2 "Carcinoma, Hepatocellular" 17188425 miRNA-19a/b activates PI3K by blocking expression of the tumor suppressor PTEN. -target gene hsa-mir-200a "Carcinoma, Hepatocellular" 17188425 "Integration at FRA1A may silence expression of miRNA-200a, which is known to be decreased in HCC compared to nontumor [59] and [65]. Since most miRNAs suppress their target proteins, and miRNA-200a is known to regulate the expression of RAB30, a member of" -target gene hsa-mir-224 Hepatitis C Virus Infection 17188425 "miRNA-224 regulates PDGFR expression, and decreases as disease progresses from chronic hepatitis to cirrhosis [59], suggesting that miRNA normally suppresses PDGFR in the liver until HBV integration and genetic instability upsets this balance. miRNA-224 a" -target gene hsa-let-7c Leiomyoma 17243163 HMGA2 was identified as one of target genes of the let-7 family of miRNAs and has been found to be suppressed by let-7 in vitro. -target gene hsa-mir-206 Breast Neoplasms 17312270 The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-alpha (ERalpha) and represses ERalpha messenger RNA and protein expression in breast cancer cell lines. -target gene hsa-let-7a-1 Neoplasms [unspecific] 17322030 Disrupting the pairing between let-7 and Hmga2 -target gene hsa-let-7a-2 Neoplasms [unspecific] 17322030 Disrupting the pairing between let-7 and Hmga2 -target gene hsa-let-7a-3 Neoplasms [unspecific] 17322030 Disrupting the pairing between let-7 and Hmga2 -target gene hsa-let-7b Neoplasms [unspecific] 17322030 Disrupting the pairing between let-7 and Hmga2 -target gene hsa-let-7c Neoplasms [unspecific] 17322030 Disrupting the pairing between let-7 and Hmga2 -target gene hsa-let-7d Neoplasms [unspecific] 17322030 Disrupting the pairing between let-7 and Hmga2 -target gene hsa-let-7e Neoplasms [unspecific] 17322030 Disrupting the pairing between let-7 and Hmga2 -target gene hsa-let-7f-1 Neoplasms [unspecific] 17322030 Disrupting the pairing between let-7 and Hmga2 -target gene hsa-let-7f-2 Neoplasms [unspecific] 17322030 Disrupting the pairing between let-7 and Hmga2 -target gene hsa-let-7g Neoplasms [unspecific] 17322030 Disrupting the pairing between let-7 and Hmga2 -target gene hsa-let-7i Neoplasms [unspecific] 17322030 Disrupting the pairing between let-7 and Hmga2 -target gene hsa-mir-302b Thyroid Neoplasms 17355635 "Genetically PTC is defined by several alterations which cause abnormal activation of the mitogen-activated protein kinase (MAPK) pathway, the most prevalent being point mutations in the intracellular signalling kinase BRAF. Of particular interest in this study is the downregulation of miR-323 and miR-302b in BRAF mutated cell line. miRBASE target database predicted that the BRAF transcript has binding sites for miR-323 and miR-302b to potentially bind and down- regulate BRAF expression." -target gene hsa-mir-323a Thyroid Neoplasms 17355635 "Genetically PTC is defined by several alterations which cause abnormal activation of the mitogen-activated protein kinase (MAPK) pathway, the most prevalent being point mutations in the intracellular signalling kinase BRAF. Of particular interest in this study is the downregulation of miR-323 and miR-302b in BRAF mutated cell line. miRBASE target database predicted that the BRAF transcript has binding sites for miR-323 and miR-302b to potentially bind and down- regulate BRAF expression." -target gene hsa-mir-122 Hepatitis C Virus Infection 17462786 "Although miRNA regulation of cellular target genes through 3'UTR binding seems to be only negative, the hepatitis C virus (HCV) has creatively made use of the liver-specific and abundantly expressed miR-122 to promote viral replication." -target gene hsa-mir-32 Viral Infectious Disease 17462786 "This has been reported for the retrovirus primate foamy virus-1 (PFV-1), which can be targeted by the host miR-32 [150], which was suggested to restrict its infection." -target gene hsa-mir-124a Pancreatic Neoplasms 17462994 MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic beta-cell lines. -target gene hsa-mir-1 Arrhythmia 17516552 "we also designed the microRNA-masking antisense based on the miR-1 and miR-133 target sites in the 3'UTRs of HCN2 and HCN4 and found that these antisense oligodeoxynucleotides markedly enhanced HCN2/HCN4 expression and function, as reflected by increased protein levels of HCN2/HCN4 and If conductance, by removing the repression of HCN2/HCN4 expression induced by endogenous miR-1/miR-133." -target gene hsa-mir-133 Arrhythmia 17516552 "we also designed the microRNA-masking antisense based on the miR-1 and miR-133 target sites in the 3'UTRs of HCN2 and HCN4 and found that these antisense oligodeoxynucleotides markedly enhanced HCN2/HCN4 expression and function, as reflected by increased protein levels of HCN2/HCN4 and If conductance, by removing the repression of HCN2/HCN4 expression induced by endogenous miR-1/miR-133." -target gene hsa-mir-221 Prostate Neoplasms 17569667 miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1. -target gene hsa-mir-222 Prostate Neoplasms 17569667 miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1. -target gene hsa-mir-122 "Carcinoma, Hepatocellular" 17616664 "Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma." -target gene hsa-mir-125b Alzheimer Disease 17629564 "The main finding was that these ROS-generating neurotoxic metal sulfates also up-regulate a specific set of miRNAs that includes miR-9, miR-125b and miR-128. Notably, these same miRNAs are up-regulated in AD brain." -target gene hsa-let-7i Immune System Disease [unspecific] 17660297 These results indicate that let-7i regulates TLR4 expression in cholangiocytes and contributes to epithelial immune responses against C. parvum infection. -target gene hsa-mir-155 Hypertension 17668390 "Since hsa-miR-155 is on chromosome 21, we hypothesize that the observed lower blood pressure in trisomy 21 is partially caused by the overexpression of hsa-miR-155 leading to allele-specific underexpression of AGTR1." -target gene hsa-mir-103a-1 Myotonic Muscular Dystrophy 17697356 "These results support a role for miRNAs in DM1 pathogenesis, and, in particular, highlight mir-107 and mir-103 as attractive candidates for binding to DMPK." -target gene hsa-mir-103a-2 Myotonic Muscular Dystrophy 17697356 "These results support a role for miRNAs in DM1 pathogenesis, and, in particular, highlight mir-107 and mir-103 as attractive candidates for binding to DMPK." -target gene hsa-mir-107 Myotonic Muscular Dystrophy 17697356 "These results support a role for miRNAs in DM1 pathogenesis, and, in particular, highlight mir-107 and mir-103 as attractive candidates for binding to DMPK." -target gene hsa-mir-145 Colon Neoplasms 17827156 Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells. -target gene hsa-mir-17 Neuroblastoma 17894887 miRNAs from the miR-17-92 cluster modulate tumor formation and function as oncogenes by influencing the translation of E2F1 mRNA. -target gene hsa-mir-18 Neuroblastoma 17894887 miRNAs from the miR-17-92 cluster modulate tumor formation and function as oncogenes by influencing the translation of E2F1 mRNA. -target gene hsa-mir-19a Neuroblastoma 17894887 miRNAs from the miR-17-92 cluster modulate tumor formation and function as oncogenes by influencing the translation of E2F1 mRNA. -target gene hsa-mir-19b-1 Neuroblastoma 17894887 miRNAs from the miR-17-92 cluster modulate tumor formation and function as oncogenes by influencing the translation of E2F1 mRNA. -target gene hsa-mir-20a Neuroblastoma 17894887 miRNAs from the miR-17-92 cluster modulate tumor formation and function as oncogenes by influencing the translation of E2F1 mRNA. -target gene hsa-mir-34a Neuroblastoma 17894887 miR-34a acts as a suppressor of neuroblastoma tumorigenesis by targeting the mRNA encoding E2F3 and reducing E2F3 protein levels. -target gene hsa-mir-92-1 Neuroblastoma 17894887 miRNAs from the miR-17-92 cluster modulate tumor formation and function as oncogenes by influencing the translation of E2F1 mRNA. -target gene hsa-mir-125b Human Immunodeficiency Virus Infection 17906637 "We have found that the 3' ends of HIV-1 messenger RNAs are targeted by a cluster of cellular miRNAs including miR-28, miR-125b, miR-150, miR-223 and miR-382, which are enriched in resting CD4+ T cells as compared to activated CD4+ T cells." -target gene hsa-mir-150 Human Immunodeficiency Virus Infection 17906637 "We have found that the 3' ends of HIV-1 messenger RNAs are targeted by a cluster of cellular miRNAs including miR-28, miR-125b, miR-150, miR-223 and miR-382, which are enriched in resting CD4+ T cells as compared to activated CD4+ T cells." -target gene hsa-mir-223 Human Immunodeficiency Virus Infection 17906637 "We have found that the 3' ends of HIV-1 messenger RNAs are targeted by a cluster of cellular miRNAs including miR-28, miR-125b, miR-150, miR-223 and miR-382, which are enriched in resting CD4+ T cells as compared to activated CD4+ T cells." -target gene hsa-mir-28 Human Immunodeficiency Virus Infection 17906637 "We have found that the 3' ends of HIV-1 messenger RNAs are targeted by a cluster of cellular miRNAs including miR-28, miR-125b, miR-150, miR-223 and miR-382, which are enriched in resting CD4+ T cells as compared to activated CD4+ T cells." -target gene hsa-mir-382 Human Immunodeficiency Virus Infection 17906637 "We have found that the 3' ends of HIV-1 messenger RNAs are targeted by a cluster of cellular miRNAs including miR-28, miR-125b, miR-150, miR-223 and miR-382, which are enriched in resting CD4+ T cells as compared to activated CD4+ T cells." -target gene hsa-mir-155 Pancreatic Neoplasms 17911264 "Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development." -target gene hsa-mir-130a Neoplasms [unspecific] 17957028 "From these data, we conclude that miR-130a is a regulator of the angiogenic phenotype of vascular ECs largely through its ability to modulate the expression of GAX and HOXA5." -target gene hsa-mir-133a-1 Arrhythmia 17965831 miR-133 was shown to inhibit the expression of ERG (ether-a-go-go-related gene) and cause depression of the potassium channel I(Kr). This inhibition contributed to long QT syndrome and arrhythmia in a diabetic rat model. -target gene hsa-mir-133a-1 Long QT Syndrome 17965831 miR-133 was shown to inhibit the expression of ERG (ether-a-go-go-related gene) and cause depression of the potassium channel I(Kr). This inhibition contributed to long QT syndrome and arrhythmia in a diabetic rat model. -target gene hsa-mir-133a-2 Arrhythmia 17965831 miR-133 was shown to inhibit the expression of ERG (ether-a-go-go-related gene) and cause depression of the potassium channel I(Kr). This inhibition contributed to long QT syndrome and arrhythmia in a diabetic rat model. -target gene hsa-mir-133a-2 Long QT Syndrome 17965831 miR-133 was shown to inhibit the expression of ERG (ether-a-go-go-related gene) and cause depression of the potassium channel I(Kr). This inhibition contributed to long QT syndrome and arrhythmia in a diabetic rat model. -target gene hsa-mir-181b Neoplasms [unspecific] 17965831 "Many miRNAs are located at chromosomal break points or fragile sites associated with cancer. Indeed miR-29a and miR-29b are associated with the fragile site FRA7H. In addition, miR-29b along with miR-181b may target the oncogene TCL1 in CLL patients [163]" -target gene hsa-mir-21 Brain Neoplasms 17965831 "The overexpression of miR-21 was recognized in malignant brain tumours, and knockdown of this miRNA in cultured glioblastoma cells resulted in caspase activation and apoptosis. The tumour suppressor tropomyosin 1 (TPM1) was demonstrated to be a target for miR-21, explaining why inhibition of miR-21 results in reduced tumour growth." -target gene hsa-mir-29a Neoplasms [unspecific] 17965831 "Many miRNAs are located at chromosomal break points or fragile sites associated with cancer. Indeed miR-29a and miR-29b are associated with the fragile site FRA7H. In addition, miR-29b along with miR-181b may target the oncogene TCL1 in CLL patients [163], while miR-29b reduced Mcl-1 protein and rendered cholangiocarcinoma cells more susceptible to apoptosis." -target gene hsa-mir-29b-1 Neoplasms [unspecific] 17965831 "Many miRNAs are located at chromosomal break points or fragile sites associated with cancer. Indeed miR-29a and miR-29b are associated with the fragile site FRA7H. In addition, miR-29b along with miR-181b may target the oncogene TCL1 in CLL patients [163], while miR-29b reduced Mcl-1 protein and rendered cholangiocarcinoma cells more susceptible to apoptosis." -target gene hsa-mir-29b-2 Neoplasms [unspecific] 17965831 "Many miRNAs are located at chromosomal break points or fragile sites associated with cancer. Indeed miR-29a and miR-29b are associated with the fragile site FRA7H. In addition, miR-29b along with miR-181b may target the oncogene TCL1 in CLL patients [163]" -target gene hsa-mir-34a Neuroblastoma 17965831 "miR-34a induces apoptosis in neuroblastoma cells, possibly by targeting the transcription factor E2F3. This p53-induced up-regulation of miR-34a results in an enhanced reduction in cell proliferation, strongly suggesting that miR-34a reinforces the tumour suppressor function of p53." -target gene hsa-mir-134 Fragile X Syndrome 17982590 spine morphology in patients with Fragile-X mental retardation syndrome (FXS) is not dissimilar from the spine structure observed on miR-134 overexpression or in neurons deficient for the miR-134 target Limk1 -target gene hsa-let-7a-1 Neoplasms [unspecific] 17989227 let-7 family members have been suggested to serve as tumor suppressors by directly inhibiting the Hmg2A and RAS protooncogenes -target gene hsa-let-7a-2 Neoplasms [unspecific] 17989227 let-7 family members have been suggested to serve as tumor suppressors by directly inhibiting the Hmg2A and RAS protooncogenes -target gene hsa-let-7a-3 Neoplasms [unspecific] 17989227 let-7 family members have been suggested to serve as tumor suppressors by directly inhibiting the Hmg2A and RAS protooncogenes -target gene hsa-let-7b Neoplasms [unspecific] 17989227 let-7 family members have been suggested to serve as tumor suppressors by directly inhibiting the Hmg2A and RAS protooncogenes -target gene hsa-let-7c Neoplasms [unspecific] 17989227 let-7 family members have been suggested to serve as tumor suppressors by directly inhibiting the Hmg2A and RAS protooncogenes -target gene hsa-let-7d Neoplasms [unspecific] 17989227 let-7 family members have been suggested to serve as tumor suppressors by directly inhibiting the Hmg2A and RAS protooncogenes -target gene hsa-let-7e Neoplasms [unspecific] 17989227 let-7 family members have been suggested to serve as tumor suppressors by directly inhibiting the Hmg2A and RAS protooncogenes -target gene hsa-let-7f-1 Neoplasms [unspecific] 17989227 let-7 family members have been suggested to serve as tumor suppressors by directly inhibiting the Hmg2A and RAS protooncogenes -target gene hsa-let-7f-2 Neoplasms [unspecific] 17989227 let-7 family members have been suggested to serve as tumor suppressors by directly inhibiting the Hmg2A and RAS protooncogenes -target gene hsa-let-7g Neoplasms [unspecific] 17989227 let-7 family members have been suggested to serve as tumor suppressors by directly inhibiting the Hmg2A and RAS protooncogenes -target gene hsa-let-7i Neoplasms [unspecific] 17989227 let-7 family members have been suggested to serve as tumor suppressors by directly inhibiting the Hmg2A and RAS protooncogenes -target gene hsa-mir-372 Neoplasms [unspecific] 17989227 "the related miR-372/373 miRNAs promote tumorigenesis in combination with oncogenic RAS, at least in part by directly inhibiting the tumor suppressor LATS2." -target gene hsa-mir-373 Neoplasms [unspecific] 17989227 "the related miR-372/373 miRNAs promote tumorigenesis in combination with oncogenic RAS, at least in part by directly inhibiting the tumor suppressor LATS2." -target gene hsa-mir-218 Cervical Neoplasms 17998940 We also show that LAMB3 expression is increased in the presence of the HPV-16 E6 oncogene and this effect is mediated through miR-218. These findings may contribute to a better understanding of the molecular mechanisms involved in cervical carcinogenesis. -target gene hsa-let-7c Neoplasms [unspecific] 18006822 "In addition to known genes, siRNAs targeting CDK4, PTGS1, ALG2, CLCN3, IRAK4, and MAP3K8 altered TRAIL-induced caspase-3 activation responses. Introduction of the miRNAs let-7c, mir-10a, mir-144, mir-150, mir-155, and mir-193 also affected the activation of the caspase cascade." -target gene hsa-mir-10a Neoplasms [unspecific] 18006822 "In addition to known genes, siRNAs targeting CDK4, PTGS1, ALG2, CLCN3, IRAK4, and MAP3K8 altered TRAIL-induced caspase-3 activation responses. Introduction of the miRNAs let-7c, mir-10a, mir-144, mir-150, mir-155, and mir-193 also affected the activation of the caspase cascade." -target gene hsa-mir-144 Neoplasms [unspecific] 18006822 "In addition to known genes, siRNAs targeting CDK4, PTGS1, ALG2, CLCN3, IRAK4, and MAP3K8 altered TRAIL-induced caspase-3 activation responses. Introduction of the miRNAs let-7c, mir-10a, mir-144, mir-150, mir-155, and mir-193 also affected the activation of the caspase cascade." -target gene hsa-mir-150 Neoplasms [unspecific] 18006822 "In addition to known genes, siRNAs targeting CDK4, PTGS1, ALG2, CLCN3, IRAK4, and MAP3K8 altered TRAIL-induced caspase-3 activation responses. Introduction of the miRNAs let-7c, mir-10a, mir-144, mir-150, mir-155, and mir-193 also affected the activation of the caspase cascade." -target gene hsa-mir-155 Neoplasms [unspecific] 18006822 "In addition to known genes, siRNAs targeting CDK4, PTGS1, ALG2, CLCN3, IRAK4, and MAP3K8 altered TRAIL-induced caspase-3 activation responses. Introduction of the miRNAs let-7c, mir-10a, mir-144, mir-150, mir-155, and mir-193 also affected the activation of the caspase cascade." -target gene hsa-mir-193 Neoplasms [unspecific] 18006822 "In addition to known genes, siRNAs targeting CDK4, PTGS1, ALG2, CLCN3, IRAK4, and MAP3K8 altered TRAIL-induced caspase-3 activation responses. Introduction of the miRNAs let-7c, mir-10a, mir-144, mir-150, mir-155, and mir-193 also affected the activation of the caspase cascade." -target gene hsa-mir-27a Breast Neoplasms 18006846 The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells. -target gene hsa-let-7b Retinoblastoma 18026111 We experimentally verified our predictions by investigating the result of let-7b downregulation in retinoblastoma using quantitative reverse transcriptase (RT)-PCR and microarray profiling: some of our verified let-7b targets include CDC25A and BCL7A. -target gene hsa-mir-221 Vascular Disease [unspecific] 18068232 "miR-221 and miR-222 block endothelial cell migration, proliferation and angiogenesis in vitro by targeting the stem cell factor receptor c-Kit and indirectly regulating expression of endothelial nitric oxide synthase." -target gene hsa-mir-222 Vascular Disease [unspecific] 18068232 "miR-221 and miR-222 block endothelial cell migration, proliferation and angiogenesis in vitro by targeting the stem cell factor receptor c-Kit and indirectly regulating expression of endothelial nitric oxide synthase." -target gene hsa-mir-378 Neoplasms [unspecific] 18077375 "Our results suggest that miR-378 transfection enhanced cell survival, tumor growth, and angiogenesis through repression of the expression of two tumor suppressors, Sufu and Fus-1." -target gene hsa-mir-101 Neoplasms [unspecific] 18096665 "The most up-regulated miR-196b and its precursors are highly expressed in the skin and showed similar tissue-specific expression patterns after treatment, indicating a common pattern of regulation by E(2). MiR-196b was shown to fine-tune the expression of its target gene Hoxb8a after treatment in whole-body homogenates." -target gene hsa-mir-146a Prostate Neoplasms 18174313 "Given that ROCK1 is one of the key kinases for the activation of hyaluronan (HA)-mediated HRPC transformation in vivo and in PC3 cells, mir-146a may function as a tumor-suppressor gene in modulating HA/ROCK1-mediated tumorigenecity in androgen-dependent prostate cancer." -target gene hsa-mir-433 Parkinson Disease 18252210 Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein. -target gene hsa-mir-224 "Carcinoma, Hepatocellular" 18319255 Profiling microRNA expression in hepatocellular carcinoma reveals microRNA-224 up-regulation and apoptosis inhibitor-5 as a microRNA-224-specific target. -target gene hsa-mir-106b Gastrointestinal Neoplasms 18328430 "Together, these results suggest that the miR-106b-25 cluster is involved in E2F1 posttranscriptional regulation and may play a key role in the development of TGFbeta resistance in gastric cancer." -target gene hsa-mir-21 Neoplasms [unspecific] 18372920 The demonstration that miR-21 promotes cell transformation supports the concept that mir-21 functions as an oncogene by a mechanism that involves translational repression of the tumor suppressor Pdcd4. -target gene hsa-mir-141 Breast Neoplasms 18376396 The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. -target gene hsa-mir-200a Breast Neoplasms 18376396 The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. -target gene hsa-mir-200b Breast Neoplasms 18376396 The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. -target gene hsa-mir-200c Breast Neoplasms 18376396 The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. -target gene hsa-mir-205 Breast Neoplasms 18376396 The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. -target gene hsa-mir-429 Breast Neoplasms 18376396 The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. -target gene hsa-let-7b Melanoma 18379589 MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth. -target gene hsa-let-7c Leiomyoma 18403645 Our findings suggest that the Let-7-mediated repression of HMGA2 mechanism can be an important molecular event in leiomyoma growth. -target gene hsa-mir-199a Ovarian Neoplasms 18408758 "Furthermore, we describe for the first time the identification of the microRNA hsa-miR-199a as a regulator of IKKbeta expression. Our study describes the property of ovarian cancer cells to enhance the inflammatory microenvironment as a result of the expression of an active IKKbeta pathway." -target gene hsa-let-7a Gastric Neoplasms 18413822 Clinical significance of high mobility group A2 in human gastric cancer and its relationship to let-7 microRNA family. -target gene hsa-mir-15b Gastric Neoplasms 18449891 miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells. -target gene hsa-mir-16-1 Gastric Neoplasms 18449891 miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells. -target gene hsa-mir-16-2 Gastric Neoplasms 18449891 miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells. -target gene hsa-mir-1-1 Hypertrophy 18458081 Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart. -target gene hsa-mir-1-2 Hypertrophy 18458081 Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart. -target gene hsa-mir-133a-1 Hypertrophy 18458081 Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart. -target gene hsa-mir-133a-2 Hypertrophy 18458081 Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart. -target gene hsa-mir-133b Hypertrophy 18458081 Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart. -target gene hsa-mir-16-1 "Lymphoma, Mantle-Cell" 18483394 Truncation in CCND1 mRNA alters miR-16-1 regulation in mantle cell lymphoma. -target gene hsa-mir-203 "Squamous Cell Carcinoma, Head and Neck" 18483491 "we have shown that miR-203 can regulate DeltaNp63 levels upon genotoxic damage in head and neck squamous cell carcinoma cells, thus controlling cell survival." -target gene hsa-mir-17 Neuroblastoma 18493594 Antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIM -target gene hsa-mir-34a Neuroblastoma 18504438 The MYCN oncogene is a direct target of miR-34a. -target gene hsa-mir-34a Neuroblastoma 18505919 A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene. -target gene hsa-mir-106a Colon Neoplasms 18521848 Deregulated expression of miR-106a predicts survival in human colon cancer patients. -target gene hsa-mir-17 Colon Neoplasms 18521848 Deregulated expression of miR-106a predicts survival in human colon cancer patients. -target gene hsa-mir-221 Vascular Disease [unspecific] 18550634 "In contrast, miR-221 and miR-222 inhibit endothelial cell migration, proliferation, and angiogenesis in vitro by targeting the stem cell factor receptor c-kit and indirectly regulating endothelial nitric oxide synthase expression." -target gene hsa-mir-222 Vascular Disease [unspecific] 18550634 "In contrast, miR-221 and miR-222 inhibit endothelial cell migration, proliferation, and angiogenesis in vitro by targeting the stem cell factor receptor c-kit and indirectly regulating endothelial nitric oxide synthase expression." -target gene hsa-mir-21 Glioma 18591254 MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. -target gene hsa-mir-206 Breast Neoplasms 18593897 miR-206 Expression is down-regulated in estrogen receptor alpha-positive human breast cancer. -target gene hsa-mir-20a Leukemia 18596985 "Here we report, for the first time, that LRF is post-transcriptionally regulated by miR-20a. Using a gene reporter assay, direct interaction of miR-20a with the LRF 3'UTR is demonstrated." -target gene hsa-mir-124-1 Medulloblastoma 18607543 miR-124: regulates cyclin dependent kinase 6 -target gene hsa-mir-124-2 Medulloblastoma 18607543 miR-124: regulates cyclin dependent kinase 6 -target gene hsa-mir-124-3 Medulloblastoma 18607543 miR-124: regulates cyclin dependent kinase 6 -target gene hsa-mir-27a Neoplasms [unspecific] 18619946 miR-27a: miR-27a and miR-451 regulate expression of MDR1/P-glycoprotein -target gene hsa-mir-451a Neoplasms [unspecific] 18619946 miR-451: miR-27a and miR-451 regulate expression of MDR1/P-glycoprotein -target gene hsa-mir-135a-1 Colorectal Carcinoma 18632633 miR-135a: miR-135 family: Regulation of the adenomatous polyposis coli gene -target gene hsa-mir-135a-2 Colorectal Carcinoma 18632633 miR-135a: miR-135 family: Regulation of the adenomatous polyposis coli gene -target gene hsa-mir-135b Colorectal Carcinoma 18632633 miR-135b: miR-135 family: Regulation of the adenomatous polyposis coli gene -target gene hsa-mir-196b Neoplasms [unspecific] 18663355 miR-196: MicroRNA-196a targets annexin A1: a microRNA-mediated mechanism of annexin A1 downregulation in cancers -target gene hsa-let-7a-1 Melanoma 18679415 let-7a: Integrin beta 3 expression is regulated by let-7a miRNA in malignant melanoma -target gene hsa-let-7a-2 Melanoma 18679415 let-7a: Integrin beta 3 expression is regulated by let-7a miRNA in malignant melanoma -target gene hsa-let-7a-3 Melanoma 18679415 let-7a: Integrin beta 3 expression is regulated by let-7a miRNA in malignant melanoma -target gene hsa-let-7b Melanoma 18679415 let-7b: Integrin beta 3 expression is regulated by let-7a miRNA in malignant melanoma -target gene hsa-let-7c Melanoma 18679415 let-7c: Integrin beta 3 expression is regulated by let-7a miRNA in malignant melanoma -target gene hsa-let-7d Melanoma 18679415 let-7d: Integrin beta 3 expression is regulated by let-7a miRNA in malignant melanoma -target gene hsa-let-7e Melanoma 18679415 let-7e: Integrin beta 3 expression is regulated by let-7a miRNA in malignant melanoma -target gene hsa-let-7f-1 Melanoma 18679415 let-7f: Integrin beta 3 expression is regulated by let-7a miRNA in malignant melanoma -target gene hsa-let-7f-2 Melanoma 18679415 let-7f: Integrin beta 3 expression is regulated by let-7a miRNA in malignant melanoma -target gene hsa-let-7g Melanoma 18679415 let-7g: Integrin beta 3 expression is regulated by let-7a miRNA in malignant melanoma -target gene hsa-let-7i Melanoma 18679415 let-7i: Integrin beta 3 expression is regulated by let-7a miRNA in malignant melanoma -target gene hsa-mir-122 "Carcinoma, Hepatocellular" 18692484 "miR-122 targets an anti-apoptotic gene, Bcl-w, in human hepatocellular carcinoma cell lines." -target gene hsa-mir-17 Breast Neoplasms 18695042 A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. -target gene hsa-mir-20a Breast Neoplasms 18695042 A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. -target gene hsa-mir-181a Immune System Disease [unspecific] 18701320 "In addition to facilitating cell fate decisions of immune cells (e.g. miR-181a and miR-223), miRs also regulate central elements of the adaptive immune response such as antigen presentation (e.g. miR-155) and T cell receptor signaling (mir-181a)." -target gene hsa-mir-221 Breast Neoplasms 18708351 miR-221: MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1 -target gene hsa-mir-222 Breast Neoplasms 18708351 miR-222: MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1 -target gene hsa-mir-34a Neoplasms [unspecific] 18755897 "Finally, miR-34a itself is a transcriptional target of p53, suggesting a positive feedback loop between p53 and miR-34a. Thus, miR-34a functions as a tumor suppressor, in part, through a SIRT1-p53 pathway." -target gene hsa-mir-125b Medulloblastoma 18756266 "Specifically, we identify miR-125b and miR-326 as suppressors of the pathway activator Smoothened together with miR-324-5p, which also targets the downstream transcription factor Gli1." -target gene hsa-mir-324 Medulloblastoma 18756266 "Specifically, we identify miR-125b and miR-326 as suppressors of the pathway activator Smoothened together with miR-324-5p, which also targets the downstream transcription factor Gli1." -target gene hsa-mir-326 Medulloblastoma 18756266 "Specifically, we identify miR-125b and miR-326 as suppressors of the pathway activator Smoothened together with miR-324-5p, which also targets the downstream transcription factor Gli1." -target gene hsa-let-7a-1 Neoplasms [unspecific] 18758960 Let-7a: Let-7a microRNA suppresses therapeutics-induced cancer cell death by targeting caspase-3 -target gene hsa-let-7a-2 Neoplasms [unspecific] 18758960 Let-7a: Let-7a microRNA suppresses therapeutics-induced cancer cell death by targeting caspase-3 -target gene hsa-let-7a-3 Neoplasms [unspecific] 18758960 Let-7a: Let-7a microRNA suppresses therapeutics-induced cancer cell death by targeting caspase-3 -target gene hsa-mir-223 Inflammation 18791161 "miR-223, which is markedly enhanced by estrogen,regulates LPS-induced IFNgamma, but not iNOS or nitric oxide in splenic lymphocytes. Inhibition of miR-223 activity decreased LPS-induced IFNgamma in splenic lymphocytes from estrogen-treated mice." -target gene hsa-mir-221 "Carcinoma, Thyroid, Papillary" 18794255 Microarray analysis showed thousands of genes were directly and indirectly regulated by miR-221 and shifted the gene expression pattern of normal thyroid cells toward PTC. -target gene hsa-mir-155 Breast Neoplasms 18794355 These data suggest that miR-155 may play an important role in TGF-beta-induced EMT and cell migration and invasion by targeting RhoA and indicate that it is a potential therapeutic target for breast cancer intervention. -target gene hsa-mir-146a Alzheimer Disease 18801740 An NF-kB-sensitive microRNA-146a-mediated inflammatory circuit in Alzheimer's disease and in stressed human brain cells. -target gene hsa-mir-128 Glioma 18810376 MicroRNA-128 inhibits glioma cells proliferation by targeting transcription factor E2F3a. -target gene hsa-mir-215 Glioma 18810376 MicroRNA-128 inhibits glioma cells proliferation by targeting transcription factor E2F3a. -target gene hsa-mir-15a Leukemia 18818396 "Using a luciferase reporter assay, we found that miR-15a directly binds the 3'-UTR of c-myb mRNA. By transfecting K562 myeloid leukemia cells with a miR-15a mimic, functionality of binding was shown." -target gene hsa-mir-192 Inflammation 18835392 "Macrophage inflammatory peptide (MIP)-2 alpha, a chemokine expressed by epithelial cells, was identified as a target of miR-192." -target gene hsa-mir-302b "Carcinoma, Embryonal" 18930031 miR-302b: miR-302b maintains stemness of human embryonal carcinoma cells by post-transcriptional regulation of Cyclin D2 expression -target gene hsa-mir-15a Prostate Neoplasms 18931683 The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities. -target gene hsa-mir-16-1 Prostate Neoplasms 18931683 The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities. -target gene hsa-mir-16-2 Prostate Neoplasms 18931683 miR-16: The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities -target gene hsa-mir-15a Polycystic Kidney Disease 18949056 miR-15a: MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis -target gene hsa-mir-296 Brain Neoplasms 18977327 "Growth factor-induced miR-296 contributes significantly to angiogenesis by directly targeting the hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) mRNA, leading to decreased levels of HGS and thereby reducing HGS-mediated degradation of the growth factor receptors VEGFR2 and PDGFRbeta." -target gene hsa-mir-128 Glioblastoma 19010882 This showed that miR-128 specifically blocked glioma self-renewal consistent with Bmi-1 down-regulation. -target gene hsa-mir-21 Glioblastoma 19013014 miR-21: MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G -target gene hsa-mir-223 Leukemia 19017354 "Thus,our results suggest that miR-223 reversibly regulates erythroid and megakaryocytic differentiation of K562 cells via down-modulation of LMO2." -target gene hsa-mir-34a Melanoma 19029026 miR-34a: MicroRNA-34a inhibits uveal melanoma cell proliferation and migration through downregulation of c-Met -target gene hsa-mir-143 "Carcinoma, Colon" 19062714 "The increased accumulation of miR-143 inhibits the proliferation of transfected cells, and results in down-regulation of K-ras protein in colorectal carcinoma." -target gene hsa-mir-29a Neoplasms [unspecific] 19079265 "miR-29a: miR-29 directly suppress p85 alpha and CDC42, both of which negatively regulate p53" -target gene hsa-mir-221 Vascular Disease [unspecific] 19088079 "Our study demonstrates that PDGF signaling, by modulating the expression of miR-221, regulates two critical determinants of the vSMC phenotype; they are SMC gene expression and cell proliferation." -target gene hsa-mir-106b "Leukemia, Lymphocytic, Chronic, B-Cell" 19096009 "miR-106b: Specific activation of microRNA106b enables the p73 apoptotic response in chronic lymphocytic leukemia by targeting the ubiquitin ligase, Itch for degradation" -target gene hsa-mir-15a Head And Neck Neoplasms 19117988 "miR-15a: feed-forward loop: PKCalpha down-regulates miR-15a, which directly inhibits protein synthesis of cyclin E" -target gene hsa-mir-221 Melanoma 19126397 miR-221: mir-221 can directly interact with c-kit 3'UTR and inhibit cKit protein translation -target gene hsa-mir-1-1 Arrhythmia 19131648 miR-1 overexpression enhances Ca(2+) release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and causing CaMKII-dependent hyperphosphorylation of RyR2 -target gene hsa-mir-1-2 Arrhythmia 19131648 miR-1 overexpression enhances Ca(2+) release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and causing CaMKII-dependent hyperphosphorylation of RyR2 -target gene hsa-mir-101-1 "Carcinoma, Hepatocellular" 19133651 miR-101: MicroRNA-101 regulates expression of the v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS) oncogene -target gene hsa-mir-101-2 "Carcinoma, Hepatocellular" 19133651 miR-101: MicroRNA-101 regulates expression of the v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS) oncogene -target gene hsa-mir-15b Glioma 19135980 MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells. -target gene hsa-mir-143 Colorectal Carcinoma 19137007 miR-143 directly recognize the 3'-untranslated region of KRAS transcripts -target gene hsa-mir-155 Immune System Disease [unspecific] 19144316 "Our studies suggest that Foxp3-dependent regulation of miR155 maintains competitive fitness of Treg cell subsets by targeting SOCS1, and they provide experimental support for a proposed role for miRNAs in ensuring the robustness of cellular phenotypes." -target gene hsa-mir-15a "Carcinoma, Nasopharyngeal" 19144710 "We found that the tumor suppressor BRCA-1 is a target of miR-15a as well as miR-16, suggesting a miRNA role in NPC pathogenesis." -target gene hsa-mir-106b Gastric Neoplasms 19153141 "miR-106b: inhibite p21,p27, and p57" -target gene hsa-mir-221 Gastric Neoplasms 19153141 "miR-221: inhibite p21,p27, and p57" -target gene hsa-mir-222 Gastric Neoplasms 19153141 "miR-222: inhibite p21,p27, and p57" -target gene hsa-mir-25 Gastric Neoplasms 19153141 "miR-25: inhibite p21,p27, and p57" -target gene hsa-mir-93 Gastric Neoplasms 19153141 "miR-93: inhibite p21,p27, and p57" -target gene hsa-mir-141 Neoplasms [unspecific] 19182522 "miR-141: miR-200 family:inhibit the initiating step of metastasis, epithelial-mesenchymal transition (EMT), by maintaining the epithelial phenotype through direct targeting of transcriptional repressors of E-cadherin, ZEB1 and ZEB2" -target gene hsa-mir-200a Neoplasms [unspecific] 19182522 "miR-200a: miR-200 family:inhibit the initiating step of metastasis, epithelial-mesenchymal transition (EMT), by maintaining the epithelial phenotype through direct targeting of transcriptional repressors of E-cadherin, ZEB1 and ZEB2" -target gene hsa-mir-200b Neoplasms [unspecific] 19182522 "miR-200b: miR-200 family:inhibit the initiating step of metastasis, epithelial-mesenchymal transition (EMT), by maintaining the epithelial phenotype through direct targeting of transcriptional repressors of E-cadherin, ZEB1 and ZEB2" -target gene hsa-mir-200c Neoplasms [unspecific] 19182522 "miR-200c: miR-200 family:inhibit the initiating step of metastasis, epithelial-mesenchymal transition (EMT), by maintaining the epithelial phenotype through direct targeting of transcriptional repressors of E-cadherin, ZEB1 and ZEB2" -target gene hsa-mir-429 Neoplasms [unspecific] 19182522 "miR-429: miR-200 family:inhibit the initiating step of metastasis, epithelial-mesenchymal transition (EMT), by maintaining the epithelial phenotype through direct targeting of transcriptional repressors of E-cadherin, ZEB1 and ZEB2" -target gene hsa-mir-1-1 Cardiomegaly 19188439 miR-1: MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes -target gene hsa-mir-1-2 Cardiomegaly 19188439 miR-1: MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes -target gene hsa-mir-182 Melanoma 19188590 miR-182: Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor -target gene hsa-mir-18a "Carcinoma, Hepatocellular" 19203451 miR-18: target BTG2 -target gene hsa-mir-18b "Carcinoma, Hepatocellular" 19203451 miR-18: target BTG2 -target gene hsa-mir-34 Neoplasms [unspecific] 19221490 "Based on this observation, we propose a positive feedback loop, in which p53 induces expression of miR-34a which suppresses SIRT1, increasing p53 activity." -target gene hsa-mir-30e Neoplasms [unspecific] 19223510 miR-30e: directly targets Ubc9 -target gene hsa-mir-10a Breast Neoplasms 19232136 miR-10a: miR-10a inhibits transcriptional of Hoxd4 -target gene hsa-mir-16-1 Breast Neoplasms 19250063 "Two new miR-16 targets: Caprin-1 and HMGA1, proteins implicated in cell proliferation" -target gene hsa-mir-16-2 Breast Neoplasms 19250063 "Two new miR-16 targets: Caprin-1 and HMGA1, proteins implicated in cell proliferation" -target gene hsa-mir-449a Prostate Neoplasms 19252524 miR-449a targets HDAC-1 and induces growth arrest in prostate cancer. -target gene hsa-mir-34b "Leukemia, Myeloid, Acute" 19258499 miR-34b: miR-34b targets cyclic AMP-responsive element binding protein -target gene hsa-mir-101-1 Urinary Bladder Cancer 19258506 miR-101: putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2 -target gene hsa-mir-101-2 Urinary Bladder Cancer 19258506 miR-101: putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2 -target gene hsa-mir-221 Marek Disease 19264608 miR-221: miR-221/222 target p27Kip1 in Marek's disease virus-transformed tumour cell line MSB-1 -target gene hsa-mir-222 Marek Disease 19264608 miR-222: miR-221/222 target p27Kip1 in Marek's disease virus-transformed tumour cell line MSB-1 -target gene hsa-mir-146b Glioma 19265686 microRNA-146b inhibits glioma cell migration and invasion by targeting MMPs. -target gene hsa-mir-328 Breast Neoplasms 19270061 MicroRNA-328 negatively regulates the expression of breast cancer resistance protein (BCRP/ABCG2) in human cancer cells. -target gene hsa-mir-205 Breast Neoplasms 19276373 miR-205: a new oncosuppressor regulates HER3 -target gene hsa-mir-21 Prostate Neoplasms 19302977 miR-21: MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells -target gene hsa-mir-21 "Cardiomyopathy, Hypertrophic" 19336275 miR-21: miR-21 can protect this by targeting PDCD4 -target gene hsa-mir-21 Heart Failure 19336275 miR-21: miR-21 can protect this by targeting PDCD4 -target gene hsa-mir-21 Myocardial Infarction 19336275 miR-21: miR-21 can protect this by targeting PDCD4 -target gene hsa-mir-21 Myocardial Ischemic-Reperfusion Injury 19336275 miR-21: miR-21 can protect this by targeting PDCD4 -target gene hsa-mir-532 Melanoma 19336521 "miR-532-5p: miR-532-5p is a regulatory factor of RUNX3, which is down-regulated during melanoma progression" -target gene hsa-mir-92a-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 19336759 "miR-92-1: overexpressed, can target the VHL transcript" -target gene hsa-mir-145 Breast Neoplasms 19360360 miR-145 inhibits breast cancer cell growth through RTKN. -target gene hsa-mir-18a "Adenocarcinoma, Colon" 19372139 The miR-18a* microRNA functions as a potential tumor suppressor by targeting on K-Ras -target gene hsa-mir-15a Multiple Myeloma 19401561 MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma. -target gene hsa-mir-16 Multiple Myeloma 19401561 MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma. -target gene hsa-mir-22 Breast Neoplasms 19414598 miR-22 inhibits estrogen signaling by directly targeting the estrogen receptor alpha mRNA. -target gene hsa-mir-106b Barrett Esophagus 19422085 "MiRs-93 and -106b targeted and inhibited p21, whereas miR-25 targeted and inhibited Bim" -target gene hsa-mir-25 Barrett Esophagus 19422085 "MiRs-93 and -106b targeted and inhibited p21, whereas miR-25 targeted and inhibited Bim" -target gene hsa-mir-93 Barrett Esophagus 19422085 "MiRs-93 and -106b targeted and inhibited p21, whereas miR-25 targeted and inhibited Bim" -target gene hsa-mir-221 Glioma 19424584 Co-suppression of miR-221/222 cluster suppresses human glioma cell growth by targeting p27kip1 in vitro and in vivo. -target gene hsa-mir-222 Glioma 19424584 Co-suppression of miR-221/222 cluster suppresses human glioma cell growth by targeting p27kip1 in vitro and in vivo. -target gene hsa-mir-124 Medulloblastoma 19427019 miR-124 is frequently down-regulated in medulloblastoma and is a negative regulator of SLC16A1. -target gene hsa-mir-143 Hepatoblastoma 19472311 Up-regulated microRNA-143 transcribed by nuclear factor kappa B enhances hepatocarcinoma metastasis by repressing fibronectin expression. -target gene hsa-mir-222 "Squamous Cell Carcinoma, Tongue" 19487542 MicroRNA-222 regulates cell invasion by targeting matrix metalloproteinase 1(MMP1) and manganese superoxide dismutase 2 (SOD2) in tongue squamous cellcarcinoma cell lines. -target gene hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 19498445 "miR-15a and miR-16-1 function by targeting multiple oncogenes, including BCL2, MCL1, CCND1, and WNT3A. Down-regulation of these miRNAs has been reported in chronic lymphocytic lymphoma (CLL), pituitary adenomas, and prostate carcinoma." -target gene hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 19498445 "miR-15a and miR-16-1 function by targeting multiple oncogenes, including BCL2, MCL1, CCND1, and WNT3A. Down-regulation of these miRNAs has been reported in chronic lymphocytic lymphoma (CLL), pituitary adenomas, and prostate carcinoma." -target gene hsa-mir-373 Esophageal Neoplasms 19501585 we demonstrated that the direct inhibition of LATS2 protein was mediated by miR-373 and manipulated the expression of miR-373 to affect esophageal cancer cells growth. -target gene hsa-mir-105 Inflammation 19509287 We identified miRNA (miR)-105 as a modulator of TLR-2 protein translation in human gingival keratinocytes. -target gene hsa-mir-127 "Lymphoma, Burkitt" 19530237 B cell differentiation in EBV-positive Burkitt Lymphoma is impaired at post-transcriptional level by miRNA altered expression. -target gene hsa-mir-34b "Leukemia, Lymphocytic, Chronic, B-Cell" 19536169 miR-34b/miR-34c: a regulator of TCL1 expression in 11q- chronic lymphocytic leukaemia -target gene hsa-mir-34c "Leukemia, Lymphocytic, Chronic, B-Cell" 19536169 miR-34b/miR-34c: a regulator of TCL1 expression in 11q- chronic lymphocytic leukaemia -target gene hsa-mir-25 Inflammation 19541842 Our study demonstrates that inhibition of miR-25 in cytokine-stimulated ASM cells up-regulates KLF4 expression via a post-transcriptional mechanism. -target gene hsa-mir-145 Prostate Neoplasms 19544444 "regulates PDGF-D, which mediate epithelial-mesenchymal transition, adhesion, and invasion, which was associated with the downregulation of ZEB1, ZEB2,and Snail2 expression;" -target gene hsa-mir-155 Glioblastoma 19559015 overexpressed; contributes to tumor resistance to VM-26 chemotherapy; targets LRRFIP1; -target gene hsa-mir-21 Glioblastoma 19559015 MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme. -target gene hsa-mir-21 Human Immunodeficiency Virus Infection 19560422 highly abundant; specifically targets the HIV-1 3'UTR region; Inhibiting miR-29a enhanced HIV-1 viral production and infectivity; specific miR-29a-HIV-1 mRNA interactions enhance viral mRNA association with RISC and P body proteins -target gene hsa-mir-200b "Adenocarcinoma, Pancreatic Ductal" 19569050 "regulate EP300, a metastasis suppressor gene; these miRs are related to reduced EP300 mRNA and protein;" -target gene hsa-mir-200c "Adenocarcinoma, Pancreatic Ductal" 19569050 "regulate EP300, a metastasis suppressor gene; these miRs are related to reduced EP300 mRNA and protein;" -target gene hsa-mir-429 "Adenocarcinoma, Pancreatic Ductal" 19569050 "regulate EP300, a metastasis suppressor gene; these miRs are related to reduced EP300 mRNA and protein;" -target gene hsa-mir-125b Breast Neoplasms 19570947 "In conclusion, this study clearly demonstrates that miR-125b post-transcriptionally regulates the CYP24, which serves as a possible mechanism for the high CYP24 expression in cancer tissues." -target gene hsa-mir-182 Breast Neoplasms 19574223 "Coordinate Regulate FOXO1; highly expressed; a novel mechanism of FOXO1 regulation, and targeting of FOXO1 by microRNAs may contribute to transformation or maintenance of an oncogenic state in breast cancer cells" -target gene hsa-mir-27a Breast Neoplasms 19574223 "Coordinate Regulation of FOXO1 by miR-27a, miR-96, and miR-182 in Breast Cancer Cells." -target gene hsa-mir-31 Breast Neoplasms 19574223 "Coordinate Regulate FOXO1; highly expressed; a novel mechanism of FOXO1 regulation, and targeting of FOXO1 by microRNAs may contribute to transformation or maintenance of an oncogenic state in breast cancer cells" -target gene hsa-mir-96 Breast Neoplasms 19574223 "Coordinate Regulate FOXO1; highly expressed; a novel mechanism of FOXO1 regulation, and targeting of FOXO1 by microRNAs may contribute to transformation or maintenance of an oncogenic state in breast cancer cells" -target gene hsa-mir-27a Prostate Neoplasms 19584056 "decreased in prostate cancer; Regulates ERBB-2 Expression; blocked downstream phosphatidylinositol 3-kinase/AKT signaling, reducing activity of an androgen-stimulated prostate-specific antigen promoter and blocking prostate-specific antigen expression" -target gene hsa-mir-331 Prostate Neoplasms 19584056 miR-311-3p regulate ERBB-2 expression and androgen receptor signaling in prostate cancer -target gene hsa-mir-331 Neoplasms [unspecific] 19584269 "miR-331-3p; a c/EBPalpha target,; Inhibits metastatic tumor antigen 1" -target gene hsa-mir-122 Neoplasms [unspecific] 19584290 "down-regulated; modulates expression of immunoinhibitory molecule B7-H3;directly target B7-H3 3' untranslated region, and knock-in and knockdown of miR-29a led to down-regulation and up-regulation of B7-H3 protein expression; potential immune based therapy" -target gene hsa-mir-122 Multiple Sclerosis 19617918 The genes targeted by hsa-miR-96 are involved inimmunological pathways as Interleukin signaling and in other pathways as wnt signaling -target gene hsa-mir-143 Colorectal Carcinoma 19638978 MicroRNA-143 targets DNA methyltransferases 3A in colorectal cancer. -target gene hsa-mir-143 Melanoma 19639204 miR-27a and its target gene ZBTB10 significantly different based on the dose of genistein -target gene hsa-mir-210 Lung Neoplasms 19654003 "low expression, targets pro-survival molecules MCL-1 and BCL2L2" -target gene hsa-mir-200b Breast Neoplasms 19665978 "downregulated, modulate Expression of BMI1, suppressed tumor formation of normal stem cell" -target gene hsa-mir-200c Neoplasms [unspecific] 19665999 inhibits through down-regulating LRP1 -target gene hsa-mir-17 Lymphoma 19666108 "The expression of these genes was also reduced in response to miR-17 and miR-20a transfection, and more specifically they were also shown to contain functional miRNA recognition elements for members of the miR-17 family by reporter gene assay." -target gene hsa-mir-20a Lymphoma 19666108 "The expression of these genes was also reduced in response to miR-17 and miR-20a transfection, and more specifically they were also shown to contain functional miRNA recognition elements for members of the miR-17 family by reporter gene assay." -target gene hsa-mir-205 "Lymphoma, Hodgkin" 19666866 "Regulates JAK2, prognostic impact" -target gene hsa-mir-197 Lung Neoplasms 19671678 regulate tumor suppressor gene FUS1 -target gene hsa-mir-93 Lung Neoplasms 19671678 regulate tumor suppressor gene FUS1 -target gene hsa-mir-98 Lung Neoplasms 19671678 regulate tumor suppressor gene FUS1 -target gene hsa-mir-221 "Carcinoma, Hepatocellular" 19671867 MicroRNA-221 targets Bmf in hepatocellular carcinoma and correlates with tumor multifocality. -target gene hsa-mir-17 Glioblastoma 19676043 "inhibite Bcl-2 and Mcl-1, induce apoptosis" -target gene hsa-mir-18a Glioblastoma 19676043 "inhibite Bcl-2 and Mcl-1, induce apoptosis" -target gene hsa-mir-19a Glioblastoma 19676043 "inhibite Bcl-2 and Mcl-1, induce apoptosis" -target gene hsa-mir-145 Vascular Disease [unspecific] 19690387 MicroRNA-modulated targeting of vascular smooth muscle cells -target gene hsa-mir-17 Vascular Disease [unspecific] 19690387 miR-17-92 and miR-17-5p/miR-20a; MicroRNA-modulated targeting of vascular smooth muscle cells -target gene hsa-mir-18a Vascular Disease [unspecific] 19690387 miR-17-92 and miR-17-5p/miR-20a; MicroRNA-modulated targeting of vascular smooth muscle cells -target gene hsa-mir-19a Vascular Disease [unspecific] 19690387 miR-17-92 and miR-17-5p/miR-20a; MicroRNA-modulated targeting of vascular smooth muscle cells -target gene hsa-mir-20a Vascular Disease [unspecific] 19690387 miR-17-92 and miR-17-5p/miR-20a; MicroRNA-modulated targeting of vascular smooth muscle cells -target gene hsa-mir-193b Breast Neoplasms 19701247 Downregulation of miR-193b contributes to enhance urokinase-type plasminogen activator (uPA) expression and tumor progression and invasion in human breast cancer. -target gene hsa-mir-9 Ovarian Neoplasms 19702828 "Ovarian cancer tissues display significantly low expression of miR-9 and a high level of NF-kappaB1 compared with normal tissues, indicating that regulation of NF-kappaB1 by miR-9 is an important mechanism for miR-9 to inhibit ovarian cancer proliferation." -target gene hsa-let-7d Cocaine Abuse 19703567 downregulated;These miRNAs target many genes involved in cocaine addiction. Precursor and mature miRNA quantification by qRT-PCR showed that miR-124 and let-7d are significantly downregulated -target gene hsa-mir-124-1 Cocaine Abuse 19703567 downregulated;These miRNAs target many genes involved in cocaine addiction. Precursor and mature miRNA quantification by qRT-PCR showed that miR-124 and let-7d are significantly downregulated -target gene hsa-mir-124-2 Cocaine Abuse 19703567 downregulated;These miRNAs target many genes involved in cocaine addiction. Precursor and mature miRNA quantification by qRT-PCR showed that miR-124 and let-7d are significantly downregulated -target gene hsa-mir-124-3 Cocaine Abuse 19703567 downregulated;These miRNAs target many genes involved in cocaine addiction. Precursor and mature miRNA quantification by qRT-PCR showed that miR-124 and let-7d are significantly downregulated -target gene hsa-mir-181a-2 Cocaine Abuse 19703567 "miR-124, let-7d and miR-181a may be involved in a complex feedback loop with cocaine-responsive plasticity genes" -target gene hsa-mir-1-1 Rhabdomyosarcoma 19710019 inhibits rhabdomyosarcoma through downregulating c-Met -target gene hsa-mir-1-2 Rhabdomyosarcoma 19710019 inhibits rhabdomyosarcoma through downregulating c-Met -target gene hsa-mir-206 Rhabdomyosarcoma 19710019 inhibits rhabdomyosarcoma through downregulating c-Met -target gene hsa-mir-15a Arthritis 19714650 "induction of apoptosis in the synovium of mice,suppresses apoptosis through inhibition of Bcl-2" -target gene hsa-mir-15a Psoriatic Arthritis 19714650 suppresses apoptosis through inhibition of Bcl-2 -target gene hsa-mir-133a-1 Cardiovascular Diseases [unspecific] 19720047 MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes -target gene hsa-mir-133a-2 Cardiovascular Diseases [unspecific] 19720047 MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes -target gene hsa-mir-133b Cardiovascular Diseases [unspecific] 19720047 MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes -target gene hsa-mir-206 Neoplasms [unspecific] 19723635 inhibits Notch3 -target gene hsa-mir-122 "Carcinoma, Hepatocellular" 19726678 "The liver specific miR-122 is frequently suppressed in primary hepatocellular carcinomas (HCCs). ADAM-10 (a distintegrin and metalloprotease family-10), SRF (serum response factor), and Igf1R (insulin like growth factor 1 receptor) that promote tumorigenesis were validated as targets of miR- 122 and were repressed by the microRNA." -target gene hsa-mir-125b-1 Breast Neoplasms 19738052 hsa-mir-125b binding site in BMPR1B is Associated with Breast cancer pathogenesis -target gene hsa-mir-125b-2 Breast Neoplasms 19738052 hsa-mir-125b binding site in BMPR1B is Associated with Breast cancer pathogenesis -target gene hsa-mir-100 Nasopharyngeal Neoplasms 19739117 miR-100 can directly target Plk1 -target gene hsa-mir-196a "Adenocarcinoma, Esophageal" 19773200 "Recent findings include the following: firstly, miRNA expression profiles can distinguish between BE and EAC; secondly, miR-196a is upregulated in EAC tissues targeting annexin A1, thereby exerting antiapoptotic effects and contributing to EAC cell survival" -target gene hsa-mir-34a Glioblastoma 19773441 MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes -target gene hsa-mir-10b "Fatty Liver, Non-Alcoholic" 19780876 "Effect of miRNA-10b in regulating cellular steatosis level by targeting PPAR-alpha expression, a novel mechanism for the pathogenesis of NAFLD" -target gene hsa-mir-125b Breast Neoplasms 19825990 "Thus, the short hairpin-looped ODN-Raf, targeting the same region of c-raf-1 as miR-125b, is a multifunctional molecule reducing the expression of oncoproteins and stimulating cell death. Both features may be useful to interfere with tumor growth." -target gene hsa-mir-449a Neoplasms [unspecific] 19833767 "Our study reveals a tumor suppressor function of miR-449a/b through regulating Rb/E2F1 activity, and suggests that escape from this regulation through an aberrant epigenetic event contributes to E2F1 deregulation and unrestricted proliferation in human cancer." -target gene hsa-mir-449b Neoplasms [unspecific] 19833767 "Our study reveals a tumor suppressor function of miR-449a/b through regulating Rb/E2F1 activity, and suggests that escape from this regulation through an aberrant epigenetic event contributes to E2F1 deregulation and unrestricted proliferation in human cancer." -target gene hsa-mir-214 Cervical Neoplasms 19859982 these results suggest that miR-214 negatively regulates HeLa cell proliferation by targeting the noncoding regions of MEK3 and JNK1 mRNAs. -target gene hsa-mir-125a Breast Neoplasms 19875930 MicroRNA-125a represses cell growth by targeting HuR in breast cancer -target gene hsa-mir-513 Infection [unspecific] 19916867 These data suggest a role of miR-513 in regulating B7-H1 expression by cholangiocytes in response to C. parvum infection. -target gene hsa-mir-372 Gastric Neoplasms 19937137 "Taken together, these findings demonstrate an oncogenic role for miR-372 in controlling cell growth, cell cycle, and apoptosis through down-regulation of a tumor suppressor gene, LATS2." -target gene hsa-mir-17 Inflammation 19949084 "In this study, we report that TNF-mediated induction of endothelial adhesion molecules can be regulated by miRNAs that are induced by TNF. Specifically, E-selectin and ICAM-1 are targets of TNF-induced miRNAs miR-31 and miR-17-3p, respectively." -target gene hsa-mir-31 Inflammation 19949084 "In this study, we report that TNF-mediated induction of endothelial adhesion molecules can be regulated by miRNAs that are induced by TNF. Specifically, E-selectin and ICAM-1 are targets of TNF-induced miRNAs miR-31 and miR-17-3p, respectively." -target gene hsa-mir-221 Glioblastoma 19953484 Up-regulation of p27(kip1) by miR-221/222 antisense oligonucleotides enhances the radiosensitivity of U251 glioblastoma] -target gene hsa-mir-222 Glioblastoma 19953484 Up-regulation of p27(kip1) by miR-221/222 antisense oligonucleotides enhances the radiosensitivity of U251 glioblastoma] -target gene hsa-mir-181b "Carcinoma, Hepatocellular" 20023698 TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3. -target gene hsa-let-7a-1 Neoplasms [unspecific] 20033209 let-7a:The let-7a microRNA protects from growth of lung carcinoma by suppression of k-Ras and c-Myc in nude mice -target gene hsa-let-7a-2 Neoplasms [unspecific] 20033209 let-7a:The let-7a microRNA protects from growth of lung carcinoma by suppression of k-Ras and c-Myc in nude mice -target gene hsa-let-7a-3 Neoplasms [unspecific] 20033209 let-7a:The let-7a microRNA protects from growth of lung carcinoma by suppression of k-Ras and c-Myc in nude mice -target gene hsa-mir-491 Colorectal Carcinoma 20039318 "miR-491:Functional screening identifies a microRNA, miR-491 that induces apoptosis by targeting Bcl-X(L) in colorectal cancer cells" -target gene hsa-mir-106a Neoplasms [unspecific] 20049626 "miR-106:Our results also indicated that miR-16/34a-c, miR-17-5p, miR-125, miR-106, and miR-150 were the upstream factors, which could regulate the expression of BCL-2, E2F1, E2F3, RB1, and P53" -target gene hsa-mir-125a Neoplasms [unspecific] 20049626 "miR-125:Our results also indicated that miR-16/34a-c, miR-17-5p, miR-125, miR-106, and miR-150 were the upstream factors, which could regulate the expression of BCL-2, E2F1, E2F3, RB1, and P53" -target gene hsa-mir-150 Neoplasms [unspecific] 20049626 "miR-150:Our results also indicated that miR-16/34a-c, miR-17-5p, miR-125, miR-106, and miR-150 were the upstream factors, which could regulate the expression of BCL-2, E2F1, E2F3, RB1, and P53" -target gene hsa-mir-16-1 Neoplasms [unspecific] 20049626 "miR-16:Our results also indicated that miR-16/34a-c, miR-17-5p, miR-125, miR-106, and miR-150 were the upstream factors, which could regulate the expression of BCL-2, E2F1, E2F3, RB1, and P53" -target gene hsa-mir-16-2 Neoplasms [unspecific] 20049626 "miR-16:Our results also indicated that miR-16/34a-c, miR-17-5p, miR-125, miR-106, and miR-150 were the upstream factors, which could regulate the expression of BCL-2, E2F1, E2F3, RB1, and P53" -target gene hsa-mir-17 Neoplasms [unspecific] 20049626 "miR-17:miR-16, miR-17, miR-34a-c, and miR-125 served as tumor suppressor miRNAs, while miR-20, miR-106, and miR-150 acted as oncogenic miRNAs" -target gene hsa-mir-20a Neoplasms [unspecific] 20049626 "miR-20:miR-16, miR-17, miR-34a-c, and miR-125 served as tumor suppressor miRNAs, while miR-20, miR-106, and miR-150 acted as oncogenic miRNAs" -target gene hsa-mir-34a Neoplasms [unspecific] 20049626 "miR-34a:Our results also indicated that miR-16/34a-c, miR-17-5p, miR-125, miR-106, and miR-150 were the upstream factors, which could regulate the expression of BCL-2, E2F1, E2F3, RB1, and P53" -target gene hsa-mir-34b Neoplasms [unspecific] 20049626 "miR-34c:Our results also indicated that miR-16/34a-c, miR-17-5p, miR-125, miR-106, and miR-150 were the upstream factors, which could regulate the expression of BCL-2, E2F1, E2F3, RB1, and P53" -target gene hsa-mir-34c Neoplasms [unspecific] 20049626 "miR-34c:Our results also indicated that miR-16/34a-c, miR-17-5p, miR-125, miR-106, and miR-150 were the upstream factors, which could regulate the expression of BCL-2, E2F1, E2F3, RB1, and P53" -target gene hsa-mir-497 Cerebral Ischemia 20053374 "Taken together, our data suggest that miR-497 promotes ischemic neuronal death by negatively regulating antiapoptotic proteins, bcl-2 and bcl-w." -target gene hsa-mir-27a Obesity 20060380 "Together, these results suggest that miR-27a would suppress adipocyte differentiation through targeting PPARgamma and thereby down-regulation of miR-27a might be associated with adipose tissue dysregulation in obesity." -target gene hsa-mir-24 Gastrointestinal Neoplasms 20062076 These findings establish a novel regulation of miR-24-related AE1 expression in gastric carcinogenesis and erythropoiesis. -target gene hsa-mir-150 Gastric Neoplasms 20067763 MiR-150 promotes gastric cancer proliferation by negatively regulating the pro-apoptotic gene EGR2 -target gene hsa-mir-15a Leukemia 20068100 "Compared with M non-IGHV3-23 CLL, the gene expression profile of M IGHV3-23 CLL was deprived in genes, including the growth/tumor suppressor genes PDCD4, TIA1, and RASSF5, whose downregulation is under control of miR-15a and miR-16-1." -target gene hsa-mir-16-1 Leukemia 20068100 "Compared with M non-IGHV3-23 CLL, the gene expression profile of M IGHV3-23 CLL was deprived in genes, including the growth/tumor suppressor genes PDCD4, TIA1, and RASSF5, whose downregulation is under control of miR-15a and miR-16-1." -target gene hsa-mir-18a Neuroblastoma 20080637 miR-18a and miR-19a target and repress the expression of estrogen receptor-alpha (ESR1) -target gene hsa-mir-19a Neuroblastoma 20080637 miR-18a and miR-19a target and repress the expression of estrogen receptor-alpha (ESR1) -target gene hsa-mir-223 "Diabetes Mellitus, Type 2" 20080987 "These data demonstrate a role for miR-223 in Glut4 regulation and glucose metabolism in the heart, reveal the pleiotropic effects of miRNAs across tissues, and show that miRNAs can upregulate target genes in terminally differentiated cardiomyocytes." -target gene hsa-mir-126 Immune System Disease [unspecific] 20083669 These data show that miR-126 is differentially regulated in CF versus non-CF airway epithelial cells and that TOM1 is a miR-126 target that may have an important role in regulating innate immune responses in the CF lung. -target gene hsa-mir-145 Colon Neoplasms 20098684 MicroRNA-145 targets YES and STAT1 in colon cancer cells. -target gene hsa-mir-7-1 Breast Neoplasms 20099276 miR-7:miR-345 and miR-7 target the human multidrug resistance-associated protein 1 -target gene hsa-mir-7-2 Breast Neoplasms 20099276 miR-7:miR-345 and miR-7 target the human multidrug resistance-associated protein 1 -target gene hsa-mir-7-3 Breast Neoplasms 20099276 miR-7:miR-345 and miR-7 target the human multidrug resistance-associated protein 1 -target gene hsa-mir-9-1 Gastric Neoplasms 20102618 miR-9 targets NF-kappaB1 and regulates gastric cancer cell growth -target gene hsa-mir-9-2 Gastric Neoplasms 20102618 miR-9 targets NF-kappaB1 and regulates gastric cancer cell growth -target gene hsa-mir-9-3 Gastric Neoplasms 20102618 miR-9 targets NF-kappaB1 and regulates gastric cancer cell growth -target gene hsa-mir-181a "Carcinoma, Lung, Non-Small-Cell" 20145152 miR-181a and miR-630 regulate cisplatin-induced cancer cell death. -target gene hsa-mir-630 "Carcinoma, Lung, Non-Small-Cell" 20145152 miR-181a and miR-630 regulate cisplatin-induced cancer cell death. -target gene hsa-mir-148a Cholangiocarcinoma 20146264 "These data indicate that IL-6 can regulate the activity of DNMT-1 and expression of methylation-dependent tumor suppressor genes by modulation of miR-148a and miR-152, and provide a link between this inflammation-associated cytokine and oncogenesis in cholangiocarcinoma." -target gene hsa-mir-152 Cholangiocarcinoma 20146264 "These data indicate that IL-6 can regulate the activity of DNMT-1 and expression of methylation-dependent tumor suppressor genes by modulation of miR-148a and miR-152, and provide a link between this inflammation-associated cytokine and oncogenesis in cholangiocarcinoma." -target gene hsa-mir-17 Multiple Sclerosis 20148420 Functional experiments with a synthetic inhibitor of miR-17 supported the link between miRNA expression and the altered target gene expression. -target gene hsa-mir-15b Neoplasms [unspecific] 20154725 "miR-15b:RECK is a target of at least three groups of miRNAs (miR-15b/16, miR-21 and miR-372/373)" -target gene hsa-mir-16-1 Neoplasms [unspecific] 20154725 "miR-16:RECK is a target of at least three groups of miRNAs (miR-15b/16, miR-21 and miR-372/373)" -target gene hsa-mir-16-2 Neoplasms [unspecific] 20154725 "miR-16:RECK is a target of at least three groups of miRNAs (miR-15b/16, miR-21 and miR-372/373)" -target gene hsa-mir-21 Neoplasms [unspecific] 20154725 "miR-21:RECK is a target of at least three groups of miRNAs (miR-15b/16, miR-21 and miR-372/373)" -target gene hsa-mir-372 Neoplasms [unspecific] 20154725 "miR-372:RECK is a target of at least three groups of miRNAs (miR-15b/16, miR-21 and miR-372/373)" -target gene hsa-mir-373 Neoplasms [unspecific] 20154725 "miR-373:RECK is a target of at least three groups of miRNAs (miR-15b/16, miR-21 and miR-372/373)" -target gene hsa-mir-181b-1 Gastric Neoplasms 20162574 miR-181b modulates multidrug resistance by targeting BCL2 in human cancer cell lines -target gene hsa-mir-181b-1 Lung Neoplasms 20162574 miR-181b modulates multidrug resistance by targeting BCL2 in human cancer cell lines -target gene hsa-mir-181b-2 Gastric Neoplasms 20162574 miR-181b modulates multidrug resistance by targeting BCL2 in human cancer cell lines -target gene hsa-mir-181b-2 Lung Neoplasms 20162574 miR-181b modulates multidrug resistance by targeting BCL2 in human cancer cell lines -target gene hsa-mir-9 Breast Neoplasms 20173740 "Here we show that miR-9, which is upregulated in breast cancer cells, directly targets CDH1, the E-cadherin-encoding messenger RNA, leading to increased cell motility and invasiveness. " -target gene hsa-mir-130b Gastric Neoplasms 20176475 miR-130b:MicroRNA-130b regulates the tumour suppressor RUNX3 in gastric cancer -target gene hsa-mir-133a Cardiomegaly 20177001 Our data show that reciprocal repression between miR-133 and calcineurin regulates cardiac hypertrophy. -target gene hsa-mir-133b Cardiomegaly 20177001 Our data show that reciprocal repression between miR-133 and calcineurin regulates cardiac hypertrophy. -target gene hsa-mir-146a Human Immunodeficiency Virus Infection 20181935 mir-146a:CCL8/MCP-2 is a target for mir-146a in HIV-1-infected human microglial cells -target gene hsa-mir-29a Alzheimer Disease 20202123 miR-29a decreased in Alzheimer disease brains targets neuron navigator-3 -target gene hsa-mir-181a Glioblastoma 20204284 MicroRNA-181a sensitizes human malignant glioma U87MG cells to radiation by targeting Bcl-2. -target gene hsa-mir-29a "Leukemia, Myeloid, Acute" 20212066 Our data indicate that miR-29a regulates early hematopoiesis and suggest that miR-29a initiates AML by converting myeloid progenitors into self-renewing LSC. -target gene hsa-mir-21 Lung Neoplasms 20223231 MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC) -target gene hsa-mir-375 Liver Neoplasms 20226166 MicroRNA-375 targets Hippo-signaling effector YAP in liver cancer and inhibits tumor properties -target gene hsa-mir-20b Breast Neoplasms 20232316 miR-20b modulates VEGF expression by targeting HIF-1alpha and STAT3 in MCF-7 breast cancer cells -target gene hsa-mir-138-1 Neoplasms [unspecific] 20232393 we demonstrate that miR-138 suppresses TSCC cell migration and invasion by regulating two key genes in the Rho GTPase signaling pathway -target gene hsa-mir-138-2 Neoplasms [unspecific] 20232393 we demonstrate that miR-138 suppresses TSCC cell migration and invasion by regulating two key genes in the Rho GTPase signaling pathway -target gene hsa-mir-218-1 Gastric Neoplasms 20300657 MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor. -target gene hsa-mir-218-2 Gastric Neoplasms 20300657 MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor. -target gene hsa-mir-193b Melanoma 20304954 MicroRNA-193b Represses Cell Proliferationand Regulates Cyclin D1 in Melanoma -target gene hsa-mir-107 Neoplasms [unspecific] 20308559 Taken together these data suggest that miR-107 can mediate p53 regulation of hypoxic signaling and tumor angiogenesis. -target gene hsa-let-7g "Carcinoma, Hepatocellular" 20309945 Hsa-let-7g inhibits proliferation of hepatocellular carcinoma Cells by down-regulation of c-Myc and Up-regulation of p16(INK4A). -target gene hsa-mir-145 Prostate Neoplasms 20332243 MicroRNA145 targets BNIP3 and suppresses prostate cancer progression. -target gene hsa-let-7g "Carcinoma, Hepatocellular" 20338660 Let-7g targets collagen type I alpha2 and inhibits cell migration in hepatocellular carcinoma. -target gene hsa-mir-21 Breast Neoplasms 20346171 our data suggests that miR-21 could promote invasion in breast cancer cells via its regulation of TIMP3 -target gene hsa-let-7a-1 "Carcinoma, Hepatocellular" 20347499 hsa-let-7a:The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma -target gene hsa-let-7a-2 "Carcinoma, Hepatocellular" 20347499 hsa-let-7a:The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma -target gene hsa-let-7a-3 "Carcinoma, Hepatocellular" 20347499 hsa-let-7a:The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma -target gene hsa-let-7b "Carcinoma, Hepatocellular" 20347499 hsa-let-7b:The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma -target gene hsa-let-7c "Carcinoma, Hepatocellular" 20347499 hsa-let-7c:The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma -target gene hsa-let-7d "Carcinoma, Hepatocellular" 20347499 hsa-let-7d:The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma -target gene hsa-let-7e "Carcinoma, Hepatocellular" 20347499 hsa-let-7e:The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma -target gene hsa-let-7f-1 "Carcinoma, Hepatocellular" 20347499 hsa-let-7f:The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma -target gene hsa-let-7f-2 "Carcinoma, Hepatocellular" 20347499 hsa-let-7f:The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma -target gene hsa-let-7g "Carcinoma, Hepatocellular" 20347499 hsa-let-7g:The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma -target gene hsa-let-7i "Carcinoma, Hepatocellular" 20347499 hsa-let-7i:The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma -target gene hsa-mir-34a Neoplasms [unspecific] 20351093 miR-34a:MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells -target gene hsa-mir-143 Prostate Neoplasms 20353999 Our data indicate that miR-143 and miR-145 are involved in the regulation of MYO6 expression and possibly in the development of prostate cancer -target gene hsa-mir-145 Prostate Neoplasms 20353999 Our data indicate that miR-143 and miR-145 are involved in the regulation of MYO6 expression and possibly in the development of prostate cancer -target gene hsa-mir-155 Breast Neoplasms 20354188 MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene -target gene hsa-let-7f-1 Ovarian Neoplasms 20354523 "When we co-transfected cells with pMIR-KLK10 and either let-7f, miR-224, or mR-516a, we saw decreased luciferase signal, suggesting that these miRNAs can target KLK10." -target gene hsa-let-7f-2 Ovarian Neoplasms 20354523 "When we co-transfected cells with pMIR-KLK10 and either let-7f, miR-224, or mR-516a, we saw decreased luciferase signal, suggesting that these miRNAs can target KLK10." -target gene hsa-mir-224 Ovarian Neoplasms 20354523 "When we co-transfected cells with pMIR-KLK10 and either let-7f, miR-224, or mR-516a, we saw decreased luciferase signal, suggesting that these miRNAs can target KLK10." -target gene hsa-mir-516a-1 Ovarian Neoplasms 20354523 "When we co-transfected cells with pMIR-KLK10 and either let-7f, miR-224, or mR-516a, we saw decreased luciferase signal, suggesting that these miRNAs can target KLK10." -target gene hsa-mir-516a-2 Ovarian Neoplasms 20354523 "When we co-transfected cells with pMIR-KLK10 and either let-7f, miR-224, or mR-516a, we saw decreased luciferase signal, suggesting that these miRNAs can target KLK10." -target gene hsa-mir-181 "Leukemia, Lymphocytic, Chronic, B-Cell" 20357824 We recently reported that levels of TCL1 expression in B-CLL are regulated by miR-29 and miR-181 that target 3' UTR of TCL1. -target gene hsa-mir-29 "Leukemia, Lymphocytic, Chronic, B-Cell" 20357824 We recently reported that levels of TCL1 expression in B-CLL are regulated by miR-29 and miR-181 that target 3' UTR of TCL1. -target gene hsa-mir-602 "Carcinoma, Hepatocellular" 20364114 MicroRNA-602 regulating tumor suppressive gene RASSF1A is overexpressed in hepatitis B virus-infected liver and hepatocellular carcinoma -target gene hsa-mir-602 Hepatitis B Virus Infection 20364114 MicroRNA-602 regulating tumor suppressive gene RASSF1A is overexpressed in hepatitis B virus-infected liver and hepatocellular carcinoma -target gene hsa-mir-155 Breast Neoplasms 20371610 "MicroRNA-155 regulates cell survival, growth and chemosensitivity by targeting FOXO3a in breast cancer" -target gene hsa-mir-512-1 "Carcinoma, Hepatocellular" 20372864 miR-512-3p:Inhibition of c-FLIP expression by miR-512-3p contributes to taxol-induced apoptosis in hepatocellular carcinoma cells -target gene hsa-mir-512-2 "Carcinoma, Hepatocellular" 20372864 miR-512-3p:Inhibition of c-FLIP expression by miR-512-3p contributes to taxol-induced apoptosis in hepatocellular carcinoma cells -target gene hsa-mir-219 "Child Development Disorders, Pervasive" 20374639 "Putative gene targets (ID3 and PLK2) of two RT-PCR-confirmed brain-specific miRNAs (hsa-miR-29b and hsa-miR-219-5p),were validated by miRNA overexpression or knockdown assays" -target gene hsa-mir-29b "Child Development Disorders, Pervasive" 20374639 "Putative gene targets (ID3 and PLK2) of two RT-PCR-confirmed brain-specific miRNAs (hsa-miR-29b and hsa-miR-219-5p),were validated by miRNA overexpression or knockdown assays" -target gene hsa-mir-15 Neoplasms [unspecific] 20385127 "Our data thus imply that miR-15a regulates cell size and proliferation by fine-tuning Dlk1 among others, and further emphasize miR-15a and DLK1 levels to play important roles in growth signaling networks." -target gene hsa-mir-212 "Carcinoma, Lung, Non-Small-Cell" 20388802 miR-212:miR-212 increases tumor necrosis factor-related apoptosis-inducing ligand sensitivity in non-small cell lung cancer by targeting the antiapoptotic protein PED -target gene hsa-mir-101 Alzheimer Disease 20395292 "Thus, miR-101 is a negative regulator of APP expression and affects the accumulation of Abeta, suggesting a possible role for miR-101 in neuropathological conditions." -target gene hsa-mir-129 Colorectal Carcinoma 20404570 our data indicate that miR-129 plays an important role in regulating cell proliferation by downregulation of Cdk6. -target gene hsa-mir-148a Prostate Neoplasms 20406806 "miR-148a:MiR-148a attenuates paclitaxel resistance of hormone-refractory, drug-resistant prostate cancer PC3 cells by regulating MSK1 expression" -target gene hsa-mir-17 Leukemia 20406979 The miR-17-92 microRNA Polycistron Regulates MLL Leukemia Stem Cell Potential by Modulating p21 Expression -target gene hsa-mir-17 "Leukemia, Myeloid, Acute" 20406979 miR-17:The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression -target gene hsa-mir-18a Leukemia 20406979 The miR-17-92 microRNA Polycistron Regulates MLL Leukemia Stem Cell Potential by Modulating p21 Expression -target gene hsa-mir-18a "Leukemia, Myeloid, Acute" 20406979 miR-18a:The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression -target gene hsa-mir-19a Leukemia 20406979 The miR-17-92 microRNA Polycistron Regulates MLL Leukemia Stem Cell Potential by Modulating p21 Expression -target gene hsa-mir-19a "Leukemia, Myeloid, Acute" 20406979 miR-19a:The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression -target gene hsa-mir-19b-1 Leukemia 20406979 The miR-17-92 microRNA Polycistron Regulates MLL Leukemia Stem Cell Potential by Modulating p21 Expression -target gene hsa-mir-19b-1 "Leukemia, Myeloid, Acute" 20406979 miR-19b:The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression -target gene hsa-mir-19b-2 Leukemia 20406979 The miR-17-92 microRNA Polycistron Regulates MLL Leukemia Stem Cell Potential by Modulating p21 Expression -target gene hsa-mir-19b-2 "Leukemia, Myeloid, Acute" 20406979 miR-19b:The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression -target gene hsa-mir-20a Leukemia 20406979 The miR-17-92 microRNA Polycistron Regulates MLL Leukemia Stem Cell Potential by Modulating p21 Expression -target gene hsa-mir-20a "Leukemia, Myeloid, Acute" 20406979 miR-20a:The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression -target gene hsa-mir-92a-1 "Leukemia, Myeloid, Acute" 20406979 miR-92a:The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression -target gene hsa-mir-92a-2 "Leukemia, Myeloid, Acute" 20406979 miR-92a:The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression -target gene hsa-mir-145 Atherosclerosis 20415654 "MicroRNAs also regulate smooth muscle cell phenotypes and control neointima formation and atherosclerosis. In this respect, miR-143 and miR-145 have been shown to play a crucial role." -target gene hsa-mir-182 Lung Neoplasms 20420807 mir-182:Hsa-mir-182 suppresses lung tumorigenesis through down regulation of RGS17 expression in vitro -target gene hsa-mir-26a Lymphoma 20441582 MicroRNA-26a-mediated regulation of interleukin-2 expression in transformed avian lymphocyte lines. -target gene hsa-mir-151a Neoplasms [unspecific] 20445018 "miR-151:down-modulating MPL and other targets of miR-28, and of related miR-708 and miR-151, could contribute to MPN pathogenicity" -target gene hsa-mir-28 Neoplasms [unspecific] 20445018 "miR-28:down-modulating MPL and other targets of miR-28, and of related miR-708 and miR-151, could contribute to MPN pathogenicity" -target gene hsa-mir-708 Neoplasms [unspecific] 20445018 "miR-708:down-modulating MPL and other targets of miR-28, and of related miR-708 and miR-151, could contribute to MPN pathogenicity" -target gene hsa-mir-155 Preeclampsia 20452491 miR-155:MicroRNA-155 contributes to preeclampsia by down-regulating CYR61 -target gene hsa-mir-20a Ovarian Neoplasms 20458444 miR-20a:miR-20a promotes proliferation and invasion by targeting APP in human ovarian cancer cells -target gene hsa-mir-125b-1 Breast Neoplasms 20460378 MicroRNA-125b:MicroRNA-125b confers the resistance of breast cancer cells to paclitaxel through suppression of pro-apoptotic Bcl-2 antagonist killer 1 (Bak1) expression -target gene hsa-mir-125b-2 Breast Neoplasms 20460378 MicroRNA-125b:MicroRNA-125b confers the resistance of breast cancer cells to paclitaxel through suppression of pro-apoptotic Bcl-2 antagonist killer 1 (Bak1) expression -target gene hsa-mir-133b Parkinson Disease 20468068 MiR-133b has been implicated in Parkinson's disease (PD) by a mechanism that involves the regulation of the transcription factor PITX3. -target gene hsa-mir-34a Glioma 20470934 "Our results demonstrate that miR-34a acts as a tumor suppressor in p53-mutant glioma cells U251, partially through regulating SIRT1." -target gene hsa-mir-21 Osteosarcoma 20480266 MicroRNA-21 is involved in osteosarcoma cell invasion and migration. -target gene hsa-mir-92a-1 Breast Neoplasms 20484043 miR-92:Estrogen receptor {beta}1 expression is regulated by miR-92 in breast cancer -target gene hsa-mir-92a-2 Breast Neoplasms 20484043 miR-92:Estrogen receptor {beta}1 expression is regulated by miR-92 in breast cancer -target gene hsa-mir-146a Chronic Heart Failure 20495188 These findings suggested that the up-regulation of miR-146a after Dox treatment is involved in acute Dox-induced cardiotoxicity by targeting ErbB4. -target gene hsa-mir-146a Psoriatic Arthritis 20500689 miR-146a:The role of microRNA-146a (miR-146a) and its target IL-1R-associated kinase (IRAK1) in psoriatic arthritis susceptibility -target gene hsa-mir-199a-1 "Carcinoma, Hepatocellular" 20501828 MiR-199a-3p:MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells -target gene hsa-mir-199a-2 "Carcinoma, Hepatocellular" 20501828 MiR-199a-3p:MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells -target gene hsa-mir-17 Breast Neoplasms 20505989 These findings suggest that miR-17-5p plays an important role in breast cancer cell invasion and migration by suppressing HBP1 and subsequent activation of Wnt/¦Â-catenin. -target gene hsa-mir-331 Gastric Neoplasms 20510161 miRNA-331-3p:miRNA-331-3p directly targets E2F1 and induces growth arrest in human gastric cancer -target gene hsa-mir-200a Breast Neoplasms 20514023 miR-200a:Our results suggest that the miR-200 family has a tumor-suppressor function by negatively regulating EGF-driven cell invasion -target gene hsa-mir-200b Breast Neoplasms 20514023 miR-200b:Our results suggest that the miR-200 family has a tumor-suppressor function by negatively regulating EGF-driven cell invasion -target gene hsa-mir-200c Breast Neoplasms 20514023 mir-200c:Our results suggest that the miR-200 family has a tumor-suppressor function by negatively regulating EGF-driven cell invasion -target gene hsa-mir-1226 Hematologic Neoplasms 20514397 These findings indicate that expression of the MUC1 oncoprotein is downregulated by miR-1226 and that miR-1226 thereby functions as a tumor suppressor by promoting the induction of cell death. -target gene hsa-mir-25 "Muscular Dystrophy, Facioscapulohumeral" 20519410 "miR-25:We report for the first time that FXR1P is regulated through miRNA binding, with one site being the miR-25/32/92/363/367 seed sequence" -target gene hsa-mir-32 "Muscular Dystrophy, Facioscapulohumeral" 20519410 "miR-32:We report for the first time that FXR1P is regulated through miRNA binding, with one site being the miR-25/32/92/363/367 seed sequence" -target gene hsa-mir-363 "Muscular Dystrophy, Facioscapulohumeral" 20519410 "miR-363:We report for the first time that FXR1P is regulated through miRNA binding, with one site being the miR-25/32/92/363/367 seed sequence" -target gene hsa-mir-367 "Muscular Dystrophy, Facioscapulohumeral" 20519410 "miR-367:We report for the first time that FXR1P is regulated through miRNA binding, with one site being the miR-25/32/92/363/367 seed sequence" -target gene hsa-mir-92a-1 "Muscular Dystrophy, Facioscapulohumeral" 20519410 "miR-92:We report for the first time that FXR1P is regulated through miRNA binding, with one site being the miR-25/32/92/363/367 seed sequence" -target gene hsa-mir-92a-2 "Muscular Dystrophy, Facioscapulohumeral" 20519410 "miR-92:We report for the first time that FXR1P is regulated through miRNA binding, with one site being the miR-25/32/92/363/367 seed sequence" -target gene hsa-mir-661 Breast Neoplasms 20543867 miR-661:miR-661 expression in SNAI1-induced epithelial to mesenchymal transition contributes to breast cancer cell invasion by targeting Nectin-1 and StarD10 messengers -target gene hsa-mir-375 Gastric Neoplasms 20548334 MiR-375:MiR-375 frequently downregulated in gastric cancer inhibits cell proliferation by targeting JAK2 -target gene hsa-mir-155 Cardiovascular Diseases [unspecific] 20550618 MicroRNA-155 prevents necrotic cell death in human cardiomyocyte progenitor cells via targeting RIP1. -target gene hsa-mir-200a Pancreatic Neoplasms 20551052 miR-200a:The elevated serum levels of miR-200a and miR-200b in most patients with pancreatic cancer could have diagnostic utility -target gene hsa-mir-200b Pancreatic Neoplasms 20551052 miR-200b:The elevated serum levels of miR-200a and miR-200b in most patients with pancreatic cancer could have diagnostic utility -target gene hsa-mir-23b Kidney Neoplasms 20562915 "miR-23b:miR-23b targets proline oxidase, a novel tumor suppressor protein in renal cancer" -target gene hsa-mir-22 Neoplasms [unspecific] 20562918 miR-22:miR-22 acts as a tumor suppressor through direct repression of MYCBP expression and subsequent reduction of oncogenic c-Myc activities. -target gene hsa-mir-1 Cardiomegaly 20571053 "Taken together, our results demonstrate that the cytoskeleton regulatory protein twinfilin-1 is a novel target of miR-1, and that reduction of miR-1 by hypertrophic stimuli induces the upregulation of twinfilin-1, which in turn evokes hypertrophy through the regulation of cardiac cytoskeleton." -target gene hsa-mir-101-1 Neoplasms [unspecific] 20586854 miR-101:Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiation -target gene hsa-mir-101-2 Neoplasms [unspecific] 20586854 miR-101:Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiation -target gene hsa-mir-185 Neoplasms [unspecific] 20603620 miRNA-185:MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers -target gene hsa-mir-96 Pancreatic Neoplasms 20610624 miRNA-96:miRNA-96 suppresses KRAS and functions as a tumor suppressor gene in pancreatic cancer -target gene hsa-mir-149 Neoplasms [unspecific] 20623644 miR-149:miR-149* induces apoptosis by inhibiting Akt1 and E2F1 in human cancer cells -target gene hsa-mir-27a Ovarian Neoplasms 20624637 MiR-27a:MiR-27a modulates MDR1/P-glycoprotein expression by targeting HIPK2 in human ovarian cancer cells -target gene hsa-mir-10a Atherosclerosis 20624982 miR-10a:miR-10a contributes to the regulation of proinflammatory endothelial phenotypes in athero-susceptible regions in vivo -target gene hsa-mir-135a Inflammation 20634564 "Specifically, miR-181a and b, miR-9, miR-204, miR-199b, and miR-135a suppressed SIRT1 protein expression." -target gene hsa-mir-181a Inflammation 20634564 "Specifically, miR-181a and b, miR-9, miR-204, miR-199b, and miR-135a suppressed SIRT1 protein expression." -target gene hsa-mir-181b Inflammation 20634564 "Specifically, miR-181a and b, miR-9, miR-204, miR-199b, and miR-135a suppressed SIRT1 protein expression." -target gene hsa-mir-199b Inflammation 20634564 "Specifically, miR-181a and b, miR-9, miR-204, miR-199b, and miR-135a suppressed SIRT1 protein expression." -target gene hsa-mir-204 Inflammation 20634564 "Specifically, miR-181a and b, miR-9, miR-204, miR-199b, and miR-135a suppressed SIRT1 protein expression." -target gene hsa-mir-9 Inflammation 20634564 "Specifically, miR-181a and b, miR-9, miR-204, miR-199b, and miR-135a suppressed SIRT1 protein expression." -target gene hsa-mir-137 Melanoma 20644734 miR-137:Our data show that miR-148 and miR-137 present an additional level of regulating Mitf expression in melanocytes and melanoma cells. -target gene hsa-mir-148a Melanoma 20644734 miR-148:Our data show that miR-148 and miR-137 present an additional level of regulating Mitf expression in melanocytes and melanoma cells. -target gene hsa-mir-27a Ovarian Neoplasms 20646448 "The expression of miR-27a is upregulated in A2780/Taxol cells, which may regulate MDR1 and P-gp expression by targeting HIPK2." -target gene hsa-mir-326 Glioma 20667897 Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells -target gene hsa-mir-217 Pancreatic Neoplasms 20675343 The miR-217 microRNA functions as a potential tumor suppressor in pancreatic ductal adenocarcinoma by targeting KRAS. -target gene hsa-mir-489 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 20700123 miR-489:miR-489 is a tumour-suppressive miRNA target PTPN11 in hypopharyngeal squamous cell carcinoma -target gene hsa-mir-21 Barrett Esophagus 20702469 "These data support a significant role for PDCD4 downregulation in the progression of BM to BAc, and confirm miR-21 as a negative regulator of PDCD4 in vivo. Further efforts are needed to validate PDCD4 as a potential prognostic marker in patients with Barrett's oesophagus." -target gene hsa-mir-106b Alzheimer Disease 20709030 miR-106b aberrantly expressed in a double transgenic mouse model for Alzheimer's disease targets TGF-¦Â type II receptor. -target gene hsa-mir-146a "Carcinoma, Renal Cell" 20709800 Loss of inducible nitric oxide synthase expression in the mouse renal cell carcinoma cell line RENCA is mediated by microRNA miR-146a. -target gene hsa-mir-101-1 Gastric Neoplasms 20712078 miR-101-3p: MicroRNA-101 is down-regulated in gastric cancer and involved in cell migration and invasion -target gene hsa-mir-101-2 Gastric Neoplasms 20712078 miR-101-3p: MicroRNA-101 is down-regulated in gastric cancer and involved in cell migration and invasion -target gene hsa-mir-125a "Carcinoma, Lung, Non-Small-Cell" 20723344 hsa-miR-125a-5p could up-regulate Rock-1 and enhance invasion in lung cancer cells. -target gene hsa-mir-145 Colon Neoplasms 20737575 "Taken together, these results suggest that miR-145 functions as a tumor suppressor by down-regulating oncogenic FLI1 in colon cancer." -target gene hsa-mir-221 Glioblastoma 20813046 "To our knowledge, these data indicate for the first time that miR-221/222 directly regulate apoptosis by targeting PUMA in glioblastoma and that miR-221/222 could be potential therapeutic targets for glioblastoma intervention." -target gene hsa-mir-222 Glioblastoma 20813046 "To our knowledge, these data indicate for the first time that miR-221/222 directly regulate apoptosis by targeting PUMA in glioblastoma and that miR-221/222 could be potential therapeutic targets for glioblastoma intervention." -target gene hsa-mir-24-1 "Squamous Cell Carcinoma, Tongue" 20816961 miR-24:MicroRNA-24 targeting RNA-binding protein DND1 in tongue squamous cell carcinoma -target gene hsa-mir-24-2 "Squamous Cell Carcinoma, Tongue" 20816961 miR-24:MicroRNA-24 targeting RNA-binding protein DND1 in tongue squamous cell carcinoma -target gene hsa-mir-148a Prostate Neoplasms 20820187 miR-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression. -target gene hsa-mir-21 "Carcinoma, Colon" 20826792 miR-21 and miR-31 converge on TIAM1 to regulate migration and invasion of colon carcinoma cells. -target gene hsa-mir-31 "Carcinoma, Colon" 20826792 miR-21 and miR-31 converge on TIAM1 to regulate migration and invasion of colon carcinoma cells. -target gene hsa-mir-21 "Squamous Cell Carcinoma, Oral" 20831814 Programmed cell death 4 loss increases tumor cell invasion and is regulated by miR-21 in oral squamous cell carcinoma. -target gene hsa-mir-494 Ischemia 20837890 miR-494:MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/reperfusion-induced cardiac injury -target gene hsa-mir-494 Ischemia-Reperfusion Injury 20837890 miR-494:MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/reperfusion-induced cardiac injury -target gene hsa-mir-145 Vascular Injuries 20841497 "In addition, specific miRNAs such as miR-145, miR-21, and miR-221 have been found to regulate neointimal hyperplasia following vascular injury, which provides interesting possibilities for future herapeutical targets against vascular disease." -target gene hsa-mir-1 Bladder Neoplasms 20843712 "Our data indicate that LASP1 may have an oncogenic function and that it might be regulated by miR-1, miR-133a, and miR-218, which may function as tumor suppressive miRNAs in BC." -target gene hsa-mir-133a Bladder Neoplasms 20843712 "Our data indicate that LASP1 may have an oncogenic function and that it might be regulated by miR-1, miR-133a, and miR-218, which may function as tumor suppressive miRNAs in BC." -target gene hsa-mir-145 Bladder Neoplasms 20843712 "Our data indicate that LASP1 may have an oncogenic function and that it might be regulated by miR-1, miR-133a, and miR-218, which may function as tumor suppressive miRNAs in BC." -target gene hsa-mir-17 Neoplasms [unspecific] 20851997 "miR-17-92 inhibits apoptosis by suppressing Pten via the miR-19 components, our results indicate that this miRNA cluster promotes tumorigenesis by antagonizing both tumor-suppressing mechanisms, apoptosis, and senescence, through the activities of different miRNA components encoded in this cluster" -target gene hsa-mir-18 Neoplasms [unspecific] 20851997 "miR-17-92 inhibits apoptosis by suppressing Pten via the miR-19 components, our results indicate that this miRNA cluster promotes tumorigenesis by antagonizing both tumor-suppressing mechanisms, apoptosis, and senescence, through the activities of different miRNA components encoded in this cluster" -target gene hsa-mir-19a Neoplasms [unspecific] 20851997 "miR-17-92 inhibits apoptosis by suppressing Pten via the miR-19 components, our results indicate that this miRNA cluster promotes tumorigenesis by antagonizing both tumor-suppressing mechanisms, apoptosis, and senescence, through the activities of different miRNA components encoded in this cluster" -target gene hsa-mir-19b-1 Neoplasms [unspecific] 20851997 "miR-17-92 inhibits apoptosis by suppressing Pten via the miR-19 components, our results indicate that this miRNA cluster promotes tumorigenesis by antagonizing both tumor-suppressing mechanisms, apoptosis, and senescence, through the activities of different miRNA components encoded in this cluster" -target gene hsa-mir-20a Neoplasms [unspecific] 20851997 "miR-17-92 inhibits apoptosis by suppressing Pten via the miR-19 components, our results indicate that this miRNA cluster promotes tumorigenesis by antagonizing both tumor-suppressing mechanisms, apoptosis, and senescence, through the activities of different miRNA components encoded in this cluster" -target gene hsa-mir-92-1 Neoplasms [unspecific] 20851997 "miR-17-92 inhibits apoptosis by suppressing Pten via the miR-19 components, our results indicate that this miRNA cluster promotes tumorigenesis by antagonizing both tumor-suppressing mechanisms, apoptosis, and senescence, through the activities of different miRNA components encoded in this cluster" -target gene hsa-mir-107 Leukemia 20884628 "Recent findings indicate that GRN is regulated strongly by the microRNA miR-107, which functionally overlaps with miR-15, miR-16, and miR-195 due to a common 5' sequence critical for target specificity. " -target gene hsa-mir-15 Leukemia 20884628 "Recent findings indicate that GRN is regulated strongly by the microRNA miR-107, which functionally overlaps with miR-15, miR-16, and miR-195 due to a common 5' sequence critical for target specificity. " -target gene hsa-mir-16 Leukemia 20884628 "Recent findings indicate that GRN is regulated strongly by the microRNA miR-107, which functionally overlaps with miR-15, miR-16, and miR-195 due to a common 5' sequence critical for target specificity. " -target gene hsa-mir-195 Leukemia 20884628 "Recent findings indicate that GRN is regulated strongly by the microRNA miR-107, which functionally overlaps with miR-15, miR-16, and miR-195 due to a common 5' sequence critical for target specificity. " -target gene hsa-mir-181a Congenital Heart Diseases 20884876 "We showed that Dicer loss of function was, at least in part, mediated by miRNA-21 (miR-21) and miRNA-181a (miR-181a), which in turn repressed the protein level of Sprouty 2, an inhibitor of Erk1/2 signaling." -target gene hsa-mir-21 Congenital Heart Diseases 20884876 "We showed that Dicer loss of function was, at least in part, mediated by miRNA-21 (miR-21) and miRNA-181a (miR-181a), which in turn repressed the protein level of Sprouty 2, an inhibitor of Erk1/2 signaling." -target gene hsa-mir-196b "Leukemia, Lymphoblastic, Acute" 20924650 Results of the present study revealed that miR-196b becomes non-functional in T-cell ALL as a consequence of mutations in 3'-UTR of c-myc gene in T-cell ALL cellular models. -target gene hsa-mir-125b Neoplasms [unspecific] 20935678 "Thus, beyond miR-125b and miR-504, the human TP53 gene is negatively regulated by two more miRNAs: miR-25 and miR-30d." -target gene hsa-mir-25 Neoplasms [unspecific] 20935678 "Thus, beyond miR-125b and miR-504, the human TP53 gene is negatively regulated by two more miRNAs: miR-25 and miR-30d." -target gene hsa-mir-30d Neoplasms [unspecific] 20935678 "Thus, beyond miR-125b and miR-504, the human TP53 gene is negatively regulated by two more miRNAs: miR-25 and miR-30d." -target gene hsa-mir-504 Neoplasms [unspecific] 20935678 "Thus, beyond miR-125b and miR-504, the human TP53 gene is negatively regulated by two more miRNAs: miR-25 and miR-30d." -target gene hsa-mir-146b Inflammation 20956612 "e.g., miR-146b targeted NF-¦ÊB signaling, and miR-219 targeted 5-lipoxygenase and reduced leukotriene production." -target gene hsa-mir-219 Inflammation 20956612 "e.g., miR-146b targeted NF-¦ÊB signaling, and miR-219 targeted 5-lipoxygenase and reduced leukotriene production." -target gene hsa-mir-93 Glioblastoma 20956944 MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-¦Â8. -target gene hsa-mir-16 Multiple Myeloma 20962322 "We validated designated genes showing binding sites within the conserved 3'-UTR and also within the mRNA coding region as direct miR-16 targets, thus indicating that the miRNAs may have many more targets than anticipated by conventional prediction methods." -target gene hsa-mir-31 Endometrial Neoplasms 20980827 "These findings provide new insights into tumor-stroma interaction and document that miR-31 and its target gene SATB2, are involved in regulation of tumor cell motility." -target gene hsa-mir-107 Gastrointestinal Neoplasms 21029372 "MicroRNA-107, an oncogene microRNA that regulates tumour invasion and metastasis by targeting DICER1 in gastric cancer." -target gene hsa-mir-137 Melanoma 21051724 The results showed that miR-137 can act as a tumor suppressor in uveal melanoma cell proliferation through downregulation of the targets MITF and CDK6. miR-137 may be epigenetically silenced during uveal melanoma tumorigenesis. -target gene hsa-mir-34a "Carcinoma, Rectal" 21067862 "These findings suggest that miR-34a targeting the Sirt1 and E2F3 genes could negatively regulate, at least in part, the resistance to 5-FU in human colorectal cancer DLD-1 cells." -target gene hsa-mir-101 Immune System Disease [unspecific] 21068409 "Together, these results indicate that miR-101 regulates the innate immune responses of macrophages to LPS through targeting MKP-1." -target gene hsa-mir-221 Prostate Neoplasms 21071579 This study demonstrates for the first time that prostate cancer cells have decreased level of ARHI which could be caused by direct targeting of 3'UTR of ARHI by miR221/222. -target gene hsa-mir-211 Melanoma 21072171 "our findings that miR-211 is a direct posttranscriptional regulator of KCNMA1 expression as well as the dependence of this miRNA's expression on MITF activity, establishes miR-211 as an important regulatory agent in human melanoma." -target gene hsa-mir-196a Melanoma 21077158 "As it was stated before that miR-196a might negatively regulate expression of the transcription factor HOX-C8, we analyzed HOX-C8 levels in NHEMs and melanoma cells and found a strong up-regulation of HOX-C8 expression in malignant melanoma cell lines and tissue samples compared with melanocytes." -target gene hsa-mir-138 "Squamous Cell Carcinoma, Tongue" 21079996 Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma. -target gene hsa-mir-191 Ovarian Neoplasms 21084273 "We conclude that acquisition of an illegitimate miR-191 target site causes downregulation of MDM4 expression,thereby significantly delaying ovarian carcinoma progression and tumor-related death." -target gene hsa-mir-373 Cholangiocarcinoma 21086164 "miR-373 is one negative regulator of MBD2. In hilar cholangiocarcinoma, down-expression of miR-373 leads to increase of MBD2, which in turn suppresses the methylation-mediated gene such as RASSF1A." -target gene hsa-mir-145 Lung Neoplasms 21092188 miRNA-145 inhibits non-small cell lung cancer cell proliferation by targeting c-Myc. -target gene hsa-mir-221 Glioblastoma 21109963 "These results were confirmed by the protein expression of p27kip1, the validated target of miR-221/222, the effect on cell cycle arrest in G1 phase, and the impact on cell apoptosis." -target gene hsa-mir-222 Glioblastoma 21109963 "These results were confirmed by the protein expression of p27kip1, the validated target of miR-221/222, the effect on cell cycle arrest in G1 phase, and the impact on cell apoptosis." -target gene hsa-let-7 Ovarian Neoplasms 21109987 Involvement of let-7/miR-98 microRNAs in the regulation of progesterone receptor membrane component 1 expression in ovarian cancer cells. -target gene hsa-mir-98 Ovarian Neoplasms 21109987 Involvement of let-7/miR-98 microRNAs in the regulation of progesterone receptor membrane component 1 expression in ovarian cancer cells. -target gene hsa-mir-10a Neuroblastoma 21118818 MicroRNAs-10a and -10b contribute to retinoic acid-induced differentiation of neuroblastoma cells and target the alternative splicing regulatory factor SFRS1 -target gene hsa-mir-296 Prostate Neoplasms 21138859 Regulation of HMGA1 expression by microRNA296 affects prostate cancer growth and invasion -target gene hsa-mir-128-1 Neuroblastoma 21143953 Overexpression of miR-128 specifically inhibits the truncated isoform of NTRK3 and upregulates BCL2 in SH-SY5Y neuroblastoma cells. -target gene hsa-mir-128-2 Neuroblastoma 21143953 Overexpression of miR-128 specifically inhibits the truncated isoform of NTRK3 and upregulates BCL2 in SH-SY5Y neuroblastoma cells. -target gene hsa-mir-17 Neuroblastoma 21145484 The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-beta Pathway in Neuroblastoma. -target gene hsa-mir-18a Neuroblastoma 21145484 The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-beta Pathway in Neuroblastoma. -target gene hsa-mir-19a Neuroblastoma 21145484 The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-beta Pathway in Neuroblastoma. -target gene hsa-mir-19b-1 Neuroblastoma 21145484 The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-beta Pathway in Neuroblastoma. -target gene hsa-mir-20a Neuroblastoma 21145484 The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-beta Pathway in Neuroblastoma. -target gene hsa-mir-92a-1 Neuroblastoma 21145484 The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-beta Pathway in Neuroblastoma. -target gene hsa-mir-43c Gastrointestinal Neoplasms 21156161 "Furthermore, a luciferase reporter assay demonstrates that miR-43c directly targets adherens junctions' transmembrane protein (VEZT) and suppresses VEZT protein expression." -target gene hsa-mir-218-1 "Carcinoma, Lung, Non-Small-Cell" 21159652 Paxillin Predicts Survival and Relapse in Non-Small Cell Lung Cancer by MicroRNA-218 Targeting. -target gene hsa-mir-218-2 "Carcinoma, Lung, Non-Small-Cell" 21159652 Paxillin Predicts Survival and Relapse in Non-Small Cell Lung Cancer by MicroRNA-218 Targeting. -target gene hsa-mir-146a Thyroid Neoplasms 21159845 Papillary Thyroid Carcinoma (PTC). Direct interaction with THRB was shown for miR-21 and miR-146a. -target gene hsa-mir-21 Thyroid Neoplasms 21159845 Papillary Thyroid Carcinoma (PTC). Direct interaction with THRB was shown for miR-21 and miR-146a. -target gene hsa-mir-181a-1 "Squamous Cell Carcinoma, Oral" 21167132 miR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras -target gene hsa-mir-181a-2 "Squamous Cell Carcinoma, Oral" 21167132 miR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras -target gene hsa-mir-21 Dementia 21170291 MicroRNA-21 dysregulates the expression of MEF2C in neurons in monkey and human SIV/HIV neurological disease. -target gene hsa-mir-593 Esophageal Neoplasms 21170987 Polo-like kinase 1 regulates cell proliferation and is targeted by miR-593* in esophageal cancer. -target gene hsa-mir-103a-1 Alzheimer Disease 21179570 "microRNAs 103 and 107 repress translation of cofilin, and that reduced levels of miR-103 or miR-107 are associated with elevated cofilin protein levels and formation of rod-like structures in a transgenic mouse model of AD" -target gene hsa-mir-103a-2 Alzheimer Disease 21179570 "microRNAs 103 and 107 repress translation of cofilin, and that reduced levels of miR-103 or miR-107 are associated with elevated cofilin protein levels and formation of rod-like structures in a transgenic mouse model of AD" -target gene hsa-mir-107 Alzheimer Disease 21179570 "microRNAs 103 and 107 repress translation of cofilin, and that reduced levels of miR-103 or miR-107 are associated with elevated cofilin protein levels and formation of rod-like structures in a transgenic mouse model of AD" -target gene hsa-mir-34a Neuroblastoma 21182263 "YY1 is a negative regulator of p53, and it plays an essential role in cancer biology. Therefore, YY1 is another important direct target of miR-34a which closely regulates TP53 activities." -target gene hsa-mir-185 Colorectal Carcinoma 21186079 "miR-185 targets RhoA and Cdc42 expression and inhibits the proliferation potential of human colorectal cells.miR-185 is a negative regulator of RhoA and Cdc42 and their cellular activities, and could inhibit proliferation and invasion of colorectal cancer" -target gene hsa-mir-21 Leukemia 21187093 Involvement of miR-21 in resistance to daunorubicin by regulating PTEN expression in the leukaemia K562 cell line. -target gene hsa-mir-199a-1 Neoplasms [unspecific] 21189327 microRNAs miR-199a-5p and -3p target the Brm subunit of SWI/SNF to generate a double-negative feedback loop in a variety of human cancers. -target gene hsa-mir-199a-2 Neoplasms [unspecific] 21189327 microRNAs miR-199a-5p and -3p target the Brm subunit of SWI/SNF to generate a double-negative feedback loop in a variety of human cancers. -target gene hsa-mir-135a "Carcinoma, Rectal" 21192341 "In this issue, Li and colleagues describe a novel way of targeting miRNA, by using a naturally occurring anti-cancer compound found in mistletoe which they showed to down-regulate miR-135a&b, which target the 3' untranslated region of adenomatous polyposis coli gene, the inactivation of which is a major initiating event in colorectal tumourigenesis." -target gene hsa-mir-135b "Carcinoma, Rectal" 21192341 "In this issue, Li and colleagues describe a novel way of targeting miRNA, by using a naturally occurring anti-cancer compound found in mistletoe which they showed to down-regulate miR-135a&b, which target the 3' untranslated region of adenomatous polyposis coli gene, the inactivation of which is a major initiating event in colorectal tumourigenesis." -target gene hsa-mir-143 Prostate Neoplasms 21197560 miR-143 decreases prostate cancer cells proliferation and migration and enhances their sensitivity to docetaxel through suppression of KRAS -target gene hsa-mir-26a-1 Nasopharyngeal Neoplasms 21199804 MiR-26a Inhibits Cell Growth and Tumorigenesis of Nasopharyngeal Carcinoma through Repression of EZH2 -target gene hsa-mir-26a-2 Nasopharyngeal Neoplasms 21199804 MiR-26a Inhibits Cell Growth and Tumorigenesis of Nasopharyngeal Carcinoma through Repression of EZH2 -target gene hsa-mir-96 Breast Neoplasms 21203424 Unregulated miR-96 Induces Cell Proliferation in Human Breast Cancer by Downregulating Transcriptional Factor FOXO3a. -target gene hsa-mir-203 Urinary Bladder Cancer 21205209 microRNA-203 suppresses bladder cancer development by repressing bcl-w expression. -target gene hsa-mir-15a Patau Syndrome 21205891 MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. -target gene hsa-mir-16-1 Patau Syndrome 21205891 MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. -target gene hsa-mir-16-2 Patau Syndrome 21205891 MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. -target gene hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 21205967 A microRNA/TP53 feedback circuitry is associated with CLL pathogenesis and outcome. Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. -target gene hsa-mir-15b "Leukemia, Lymphocytic, Chronic, B-Cell" 21205967 A microRNA/TP53 feedback circuitry is associated with CLL pathogenesis and outcome. Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. -target gene hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 21205967 A microRNA/TP53 feedback circuitry is associated with CLL pathogenesis and outcome. Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. -target gene hsa-mir-16-2 "Leukemia, Lymphocytic, Chronic, B-Cell" 21205967 A microRNA/TP53 feedback circuitry is associated with CLL pathogenesis and outcome. Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. -target gene hsa-mir-195 "Leukemia, Lymphocytic, Chronic, B-Cell" 21205967 A microRNA/TP53 feedback circuitry is associated with CLL pathogenesis and outcome. Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. -target gene hsa-mir-34b "Leukemia, Lymphocytic, Chronic, B-Cell" 21205967 A microRNA/TP53 feedback circuitry is associated with CLL pathogenesis and outcome. Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. -target gene hsa-mir-34c "Leukemia, Lymphocytic, Chronic, B-Cell" 21205967 A microRNA/TP53 feedback circuitry is associated with CLL pathogenesis and outcome. Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. -target gene hsa-mir-10a Neuroblastoma 21212796 MicroRNAs 10a and 10b are potent inducers of neuroblastoma cell differentiation through targeting of nuclear receptor corepressor 2. -target gene hsa-mir-10b Neuroblastoma 21212796 MicroRNAs 10a and 10b are potent inducers of neuroblastoma cell differentiation through targeting of nuclear receptor corepressor 2. -target gene hsa-mir-31 "Muscular Dystrophy, Duchenne" 21212803 miR-31 represses dystrophin expression by targeting its 3' untranslated region. -target gene hsa-mir-214 Urinary Bladder Cancer 21216304 Plexin-B1 is a target of miR-214 in cervical cancer and promotes the growth and invasion of HeLa Cells. -target gene hsa-mir-328 Breast Neoplasms 21219875 Breast cancer resistance protein BCRP/ABCG2 regulatory microRNAs (hsa-miR-328; -519c and -520h) and their differential expression in stem-like ABCG2+ cancer cells. -target gene hsa-mir-519c Breast Neoplasms 21219875 Breast cancer resistance protein BCRP/ABCG2 regulatory microRNAs (hsa-miR-328; -519c and -520h) and their differential expression in stem-like ABCG2+ cancer cells. -target gene hsa-mir-520h Breast Neoplasms 21219875 Breast cancer resistance protein BCRP/ABCG2 regulatory microRNAs (hsa-miR-328; -519c and -520h) and their differential expression in stem-like ABCG2+ cancer cells. -target gene hsa-mir-125a Gastric Neoplasms 21220473 "MicroRNA-125a-5p is an independent prognostic factor in gastric cancer,and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab." -target gene hsa-mir-137 Gastric Neoplasms 21221794 miR-137 Is Frequently Down-Regulated in Gastric Cancer and Is a Negative Regulator of Cdc42. -target gene hsa-mir-616 Prostate Neoplasms 21224345 microRNA-616 Induces Androgen-Independent Growth of Prostate Cancer Cells by Suppressing Expression of Tissue Factor Pathway Inhibitor TFPI-2. -target gene hsa-mir-376c Ovarian Neoplasms 21224400 MicroRNA 376c enhances ovarian cancer cell survival by targeting activin receptor-like kinase 7: implications for chemoresistance. -target gene hsa-mir-200a Prostate Neoplasms 21224847 Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells. -target gene hsa-mir-200b Prostate Neoplasms 21224847 Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells. -target gene hsa-mir-200c Prostate Neoplasms 21224847 Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells. -target gene hsa-mir-200a Breast Neoplasms 21224848 The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells. -target gene hsa-mir-200a Pancreatic Neoplasms 21224848 The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells. -target gene hsa-mir-200b Breast Neoplasms 21224848 The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells. -target gene hsa-mir-200b Pancreatic Neoplasms 21224848 The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells. -target gene hsa-mir-200c Breast Neoplasms 21224848 The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells. -target gene hsa-mir-200c Pancreatic Neoplasms 21224848 The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells. -target gene hsa-mir-9-1 Gastric Neoplasms 21225631 MiR-9 down-regulates CDX2 expression in gastric cancer cells. -target gene hsa-mir-9-2 Gastric Neoplasms 21225631 MiR-9 down-regulates CDX2 expression in gastric cancer cells. -target gene hsa-mir-9-3 Gastric Neoplasms 21225631 MiR-9 down-regulates CDX2 expression in gastric cancer cells. -target gene hsa-mir-340 Breast Neoplasms 21225860 miR-340 inhibition of breast cancer cell migration and invasion through targeting of oncoprotein c-Met -target gene hsa-mir-885 Neuroblastoma 21233845 "MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival." -target gene hsa-mir-155 Preeclampsia 21234519 microRNA-155 regulates angiotensin II type 1 receptor expression in umbilical vein endothelial cells from severely pre-eclamptic pregnant women. -target gene hsa-mir-146a Atherosclerosis 21236257 Our study clearly revealed that miRNA-146a regulates the maturation process and pro-inflammatory cytokine secretion in DCs by targeting CD40L in ox-LDL-stimulated DCs. -target gene hsa-mir-34a Prostate Neoplasms 21240262 The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. -target gene hsa-mir-20a Colorectal Carcinoma 21242194 miR-20a targets BNIP2 and contributes chemotherapeutic resistance in colorectal adenocarcinoma SW480 and SW620 cell lines. -target gene hsa-mir-126 Breast Neoplasms 21249429 Endothelial-specific intron-derived miR-126 is down-regulated in human breast cancer and targets both VEGFA and PIK3R2. -target gene hsa-mir-485 Leukemia 21252292 Novel regulation of NF-YB by miR-485-3p affects expression of DNA topoisomerase II{alpha} and drug responsiveness in human lymphoblastic leukemia CEM cells. -target gene hsa-mir-145 Prostate Neoplasms 21258769 "Restoration of miR-145 expression suppresses cell proliferation, migration and invasion in prostate cancer by targeting FSCN1." -target gene hsa-mir-497 Gastrointestinal Neoplasms 21258880 miR-497 modulates multidrug resistance of human cancer cell lines by targeting BCL2. -target gene hsa-mir-497 Lung Neoplasms 21258880 miR-497 modulates multidrug resistance of human cancer cell lines by targeting BCL2. -target gene hsa-mir-26b Glioma 21264258 "This study demonstrated that miR-26b may act as a tumor suppressor in glioma and it directly regulates EphA2 expression. EphA2 is a direct target of miR-26b, and the down-regulation of EphA2 mediated by miR-26b is dependent on the binding of miR-26b to a" -target gene hsa-mir-107 Gastrointestinal Neoplasms 21264532 "miR-107 targets cyclin-dependent kinase 6 expression, induces cell cycle G1 arrest and inhibits invasion in gastric cancer cells." -target gene hsa-mir-101-1 "Carcinoma, Lung, Non-Small-Cell" 21270667 MicroRNA-101 Exerts Tumor-Suppressive Functions in Non-small Cell Lung Cancer through Directly Targeting Enhancer of Zeste Homolog 2. -target gene hsa-mir-101-2 "Carcinoma, Lung, Non-Small-Cell" 21270667 MicroRNA-101 Exerts Tumor-Suppressive Functions in Non-small Cell Lung Cancer through Directly Targeting Enhancer of Zeste Homolog 2. -target gene hsa-mir-19a Esophageal Neoplasms 21271217 TNF-alpha is a novel target of miR-19a. -target gene hsa-mir-381 Systemic Mastocytosis 21273305 We found that miR-539 and miR-381 are downregulated by KIT signaling and they repressed MITF expression through conserved miRNA binding sites in the MITF 3' UTR. -target gene hsa-mir-539 Systemic Mastocytosis 21273305 We found that miR-539 and miR-381 are downregulated by KIT signaling and they repressed MITF expression through conserved miRNA binding sites in the MITF 3' UTR. -target gene hsa-mir-29a Inflammation 21276447 microRNA-29a could regulate pro-inflammatory cytokine secretion and scavenger receptor expression by targeting lipoprotein lipase in oxLDL-stimulated dendritic cells. -target gene hsa-mir-221 Colorectal Carcinoma 21278784 MicroRNA-221 inhibits CDKN1C/p57 expression in human colorectal carcinoma. -target gene hsa-mir-21 Glioma 21278789 Downregulation of Spry2 by miR-21 triggers malignancy in human gliomas. -target gene hsa-mir-137 Melanoma 21278922 MicroRNA-137 Targets Carboxyl-terminal Binding Protein 1 in Melanoma Cell Lines. -target gene hsa-mir-145 Lung Neoplasms 21289483 MiR-145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1. -target gene hsa-mir-141 Esophageal Neoplasms 21289630 MicroRNA-141 confers resistance to cisplatin-induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma. -target gene hsa-mir-101 Glioblastoma 21297974 Down-regulation of miR-101 in endothelial cells promotes blood vessel formation through reduced repression of EZH2. -target gene hsa-mir-203 Esophageal Neoplasms 21299870 MicroRNA-203 inhibits cell proliferation by repressing DeltaNp63 expression in human esophageal squamous cell carcinoma. -target gene hsa-mir-203 "Squamous Cell Carcinoma, Esophageal" 21299870 MicroRNA-203 inhibits cell proliferation by repressing DeltaNp63 expression in human esophageal squamous cell carcinoma. -target gene hsa-mir-1-1 Urinary Bladder Cancer 21304530 The tumour-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer. -target gene hsa-mir-1-2 Urinary Bladder Cancer 21304530 The tumour-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer. -target gene hsa-mir-133a-1 Urinary Bladder Cancer 21304530 The tumour-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer. -target gene hsa-mir-133a-2 Urinary Bladder Cancer 21304530 The tumour-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer. -target gene hsa-mir-126 Gastrointestinal Neoplasms 21304604 "miR-126 is a novel miRNA that targets SOX2, and PLAC1 may be a novel downstream target gene of SOX2 in gastric cancer cells. These findings suggest that aberrant over-expression of miR-126 and consequent SOX2 down-regulation may contribute to gastric carc" -target gene hsa-mir-125b-1 Prostate Neoplasms 21308711 "miR-125b suppresses MUC1 translation in LNCaP cells and that an anti-sense miR-125b upregulates expression of MUC1 protein. In addition, stable expression of miR-125b in DU145 cells resulted in decreases in MUC1 levels." -target gene hsa-mir-125b-2 Prostate Neoplasms 21308711 "miR-125b suppresses MUC1 translation in LNCaP cells and that an anti-sense miR-125b upregulates expression of MUC1 protein. In addition, stable expression of miR-125b in DU145 cells resulted in decreases in MUC1 levels." -target gene hsa-mir-155 Inflammation 21310411 "HUVECs highly expressed miR-155 may co-target AT1R and Ets-1 while miR-221/222 targets Ets-1, which indirectly regulate the expression of several inflammatory molecules of ECs, and therefore attenuate the adhesion of Jurkat T cells to activated HUVECs and" -target gene hsa-mir-221 Inflammation 21310411 "HUVECs highly expressed miR-155 may co-target AT1R and Ets-1 while miR-221/222 targets Ets-1, which indirectly regulate the expression of several inflammatory molecules of ECs, and therefore attenuate the adhesion of Jurkat T cells to activated HUVECs and" -target gene hsa-mir-222 Inflammation 21310411 "HUVECs highly expressed miR-155 may co-target AT1R and Ets-1 while miR-221/222 targets Ets-1, which indirectly regulate the expression of several inflammatory molecules of ECs, and therefore attenuate the adhesion of Jurkat T cells to activated HUVECs and" -target gene hsa-mir-29c Diabetes Mellitus 21310958 "MicroRNA-29c is a signature MicroRNA under high glucose conditions which targets sprouty homolog 1, and its in vivo knockdown prevents progression of diabetic nephropathy." -target gene hsa-mir-21 Prostate Neoplasms 21317927 MicroRNA-21 targets tumor suppressor genes ANP32A and SMARCA4 -target gene hsa-mir-21 Neoplasms [unspecific] 21328460 miR-21 downregulates the tumor suppressor P12(CDK2AP1) and Stimulates Cell Proliferation and Invasion. -target gene hsa-mir-132 Pancreatic Neoplasms 21329664 "miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor, rb1." -target gene hsa-mir-212 Pancreatic Neoplasms 21329664 miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor. -target gene hsa-mir-34b Colorectal Carcinoma 21329882 "MK5 regulates translation of Myc, since it is required for expression of miR-34b and miR-34c that bind to the 3'UTR of MYC. MK5 activates miR-34b/c expression via phosphorylation of FoxO3a, thereby promoting nuclear localization of FoxO3a and enabling it" -target gene hsa-mir-34c Colorectal Carcinoma 21329882 "MK5 regulates translation of Myc, since it is required for expression of miR-34b and miR-34c that bind to the 3'UTR of MYC. MK5 activates miR-34b/c expression via phosphorylation of FoxO3a, thereby promoting nuclear localization of FoxO3a and enabling it" -target gene hsa-mir-520b Breast Neoplasms 21343296 miR-520b regulates migration of breast cancer cells through targeting hepatitis B X-interacting protein and interleukin-8. -target gene hsa-mir-135b Prostate Neoplasms 21343391 "3'UTR-binding assays validated 13 miRNAs that are able to regulate this long AR 3'UTR (miR-135b, miR-185, miR-297, miR-299-3p, miR-34a, miR-34c, miR-371-3p, miR-421, miR-449a, miR-449b, miR-634, miR-654-5p, and miR-9)." -target gene hsa-mir-127 Breast Neoplasms 21343399 "Analyses of miRNA expression profiles identified numerous miRNAs implicated in cell proliferation including miR-127, -197, -222, and -223 targeting CXCL12." -target gene hsa-let-7a-1 Gastrointestinal Neoplasms 21349817 let-7a is significant in suppressing gastric cancer growth in vivo and in vitro and provided the first evidence that RAB40C is negatively regulated by let-7a at the post-transcriptional level via binding to the 3'-untranslated region of RAB40C mRNA in gas -target gene hsa-let-7a-2 Gastrointestinal Neoplasms 21349817 let-7a is significant in suppressing gastric cancer growth in vivo and in vitro and provided the first evidence that RAB40C is negatively regulated by let-7a at the post-transcriptional level via binding to the 3'-untranslated region of RAB40C mRNA in gas -target gene hsa-let-7a-3 Gastrointestinal Neoplasms 21349817 let-7a is significant in suppressing gastric cancer growth in vivo and in vitro and provided the first evidence that RAB40C is negatively regulated by let-7a at the post-transcriptional level via binding to the 3'-untranslated region of RAB40C mRNA in gas -target gene hsa-mir-133a-1 "Squamous Cell Carcinoma, Esophageal" 21351259 "miR-145, miR-133a and miR-133b: Tumor-suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma." -target gene hsa-mir-133a-2 "Squamous Cell Carcinoma, Esophageal" 21351259 "miR-145, miR-133a and miR-133b: Tumor-suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma." -target gene hsa-mir-133b "Squamous Cell Carcinoma, Esophageal" 21351259 "miR-145, miR-133a and miR-133b: Tumor-suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma." -target gene hsa-mir-145 "Squamous Cell Carcinoma, Esophageal" 21351259 "miR-145, miR-133a and miR-133b: Tumor-suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma." -target gene hsa-mir-451a "Carcinoma, Lung, Non-Small-Cell" 21358675 MicroRNA-451 functions as a tumor suppressor in human non-small cell lung cancer by targeting ras-related protein 14 (RAB14). -target gene hsa-mir-16-1 Laryngeal Neoplasms 21360639 MicroRNA-16 targets zyxin and promotes cell motility in human laryngeal carcinoma cell line HEp-2. -target gene hsa-mir-16-2 Laryngeal Neoplasms 21360639 MicroRNA-16 targets zyxin and promotes cell motility in human laryngeal carcinoma cell line HEp-2. -target gene hsa-mir-145 "Adenocarcinoma, Endometrial" 21365617 Up-regulation of microRNA-145 promotes differentiation by repressing OCT4 in human endometrial adenocarcinoma cells. -target gene hsa-mir-34a Leukemia 21367750 miR-34a induces the down-regulation of both E2F1 and B-Myb oncogenes in leukemic cells. -target gene hsa-mir-101-1 Nasopharyngeal Neoplasms 21368858 "Enhancer of Zeste homolog 2 (EZH2) is overexpressed in recurrent nasopharyngeal carcinoma and is regulated by miR-26a, miR-101, and miR-98." -target gene hsa-mir-101-2 Nasopharyngeal Neoplasms 21368858 "Enhancer of Zeste homolog 2 (EZH2) is overexpressed in recurrent nasopharyngeal carcinoma and is regulated by miR-26a, miR-101, and miR-98." -target gene hsa-mir-26a-1 Nasopharyngeal Neoplasms 21368858 "Enhancer of Zeste homolog 2 (EZH2) is overexpressed in recurrent nasopharyngeal carcinoma and is regulated by miR-26a, miR-101, and miR-98." -target gene hsa-mir-26a-2 Nasopharyngeal Neoplasms 21368858 "Enhancer of Zeste homolog 2 (EZH2) is overexpressed in recurrent nasopharyngeal carcinoma and is regulated by miR-26a, miR-101, and miR-98." -target gene hsa-mir-98 Nasopharyngeal Neoplasms 21368858 "Enhancer of Zeste homolog 2 (EZH2) is overexpressed in recurrent nasopharyngeal carcinoma and is regulated by miR-26a, miR-101, and miR-98." -target gene hsa-mir-21 Pancreatic Neoplasms 21376256 Bcl-2 Upregulation Induced by miR-21 Via a Direct Interaction Is Associated with Apoptosis and Chemoresistance in MIA PaCa-2 Pancreatic Cancer Cells. -target gene hsa-mir-1-1 Head And Neck Neoplasms 21378409 miR-1 as a tumor suppressive microRNA targeting TAGLN2 in head and neck squamous cell carcinoma. -target gene hsa-mir-1-1 "Squamous Cell Carcinoma, Head and Neck" 21378409 miR-1 as a tumor suppressive microRNA targeting TAGLN2 in head and neck squamous cell carcinoma. -target gene hsa-mir-1-2 Head And Neck Neoplasms 21378409 miR-1 as a tumor suppressive microRNA targeting TAGLN2 in head and neck squamous cell carcinoma. -target gene hsa-mir-1-2 "Squamous Cell Carcinoma, Head and Neck" 21378409 miR-1 as a tumor suppressive microRNA targeting TAGLN2 in head and neck squamous cell carcinoma. -target gene hsa-mir-9-1 Glioblastoma 21385897 miR-9 suppresses mesenchymal differentiation in glioblastoma by downregulating expression of JAK kinases and inhibiting activation of STAT3. -target gene hsa-mir-9-2 Glioblastoma 21385897 miR-9 suppresses mesenchymal differentiation in glioblastoma by downregulating expression of JAK kinases and inhibiting activation of STAT3. -target gene hsa-mir-9-3 Glioblastoma 21385897 miR-9 suppresses mesenchymal differentiation in glioblastoma by downregulating expression of JAK kinases and inhibiting activation of STAT3. -target gene hsa-mir-218-1 Nasopharyngeal Neoplasms 21385904 miR-218 Suppresses Nasopharyngeal Cancer Progression through Downregulation of Survivin and the SLIT2-ROBO1 Pathway. -target gene hsa-mir-218-2 Nasopharyngeal Neoplasms 21385904 miR-218 Suppresses Nasopharyngeal Cancer Progression through Downregulation of Survivin and the SLIT2-ROBO1 Pathway. -target gene hsa-mir-133a-1 Urinary Bladder Cancer 21396852 MiR-133a induces apoptosis through direct regulation of GSTP1 in bladder cancer cell lines. -target gene hsa-mir-204 Endometrial Neoplasms 21400511 Dysregulation of microRNA-204 mediates migration and invasion of endometrial cancer by regulating FOXC1. -target gene hsa-mir-125b-1 Psoriasis 21412257 "MiR-125b, a MicroRNA Downregulated in Psoriasis, Modulates Keratinocyte Proliferation by Targeting FGFR2." -target gene hsa-mir-125b-2 Psoriasis 21412257 "MiR-125b, a MicroRNA Downregulated in Psoriasis, Modulates Keratinocyte Proliferation by Targeting FGFR2." -target gene hsa-mir-204 Gastric Neoplasms 21416062 "MiR-204, which was predicted to target ezrin, was downregulated in gastric cancer cells and gastric carcinomas. MiR-204 inhibited ezrin expression, Ras activation, cell growth and cell migration" -target gene hsa-mir-10b Glioblastoma 21419107 MicroRNA-10b induces glioma cell invasion by modulating MMP-14 and uPAR expression via HOXD10. -target gene hsa-mir-205 Esophageal Neoplasms 21426561 MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells. -target gene hsa-mir-205 "Squamous Cell Carcinoma, Esophageal" 21426561 MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells. -target gene hsa-mir-95 Colorectal Carcinoma 21427358 MicroRNA-95 Promotes Cell Proliferation and Targets Sorting Nexin 1 in Human Colorectal Carcinoma. -target gene hsa-mir-126 "Carcinoma, Lung, Non-Small-Cell" 21439283 miR-126 inhibits proliferation of small cell lung cancer cells by targeting SLC7A5. -target gene hsa-mir-125b-1 Breast Neoplasms 21444677 miR-125b is Methylated and Functions as A Tumor Suppressor by Regulating the ETS1 proto-oncogene in Human Invasive Breast Cancer. -target gene hsa-mir-125b-2 Breast Neoplasms 21444677 miR-125b is Methylated and Functions as A Tumor Suppressor by Regulating the ETS1 proto-oncogene in Human Invasive Breast Cancer. -target gene hsa-mir-204 Prostate Neoplasms 21446014 "PDEF expression is regulated via a functional microRNA-204 (miR-204) binding site within the 3'UTR. Furthermore, we demonstrate the biologic significance of miR-204 expression and that miR-204 is over-expressed in human prostate cancer specimens." -target gene hsa-mir-205 Melanoma 21454583 miR-205 suppresses melanoma cell proliferation and induces senescence via regulation of E2F1. -target gene hsa-mir-7-1 Neurofibromatosis type 2 21454924 "We found that miR-7 functions as a tumor suppressor by targeting proteins in three major oncogenic pathways - EGFR, Pak1, and Ack1." -target gene hsa-mir-7-2 Neurofibromatosis type 2 21454924 "We found that miR-7 functions as a tumor suppressor by targeting proteins in three major oncogenic pathways - EGFR, Pak1, and Ack1." -target gene hsa-mir-7-3 Neurofibromatosis type 2 21454924 "We found that miR-7 functions as a tumor suppressor by targeting proteins in three major oncogenic pathways - EGFR, Pak1, and Ack1." -target gene hsa-mir-148a Colorectal Carcinoma 21455217 MiR-148a promotes apoptosis by targeting Bcl-2 in colorectal cancer. -target gene hsa-mir-24-2 Breast Neoplasms 21463514 miR-24-2 controls H2AFX expression regardless of gene copy number alteration and induces apoptosis by targeting anti-apoptotic gene BCL-2: a potential for therapeutic intervention. -target gene hsa-let-7g Lung Neoplasms 21464588 miR-9 and let-7g enhance the sensitivity to ionizing radiation by suppression of NFKB1. -target gene hsa-mir-9-1 Lung Neoplasms 21464588 miR-9 and let-7g enhance the sensitivity to ionizing radiation by suppression of NFKB1. -target gene hsa-mir-9-2 Lung Neoplasms 21464588 miR-9 and let-7g enhance the sensitivity to ionizing radiation by suppression of NFKB1. -target gene hsa-mir-9-3 Lung Neoplasms 21464588 miR-9 and let-7g enhance the sensitivity to ionizing radiation by suppression of NFKB1. -target gene hsa-mir-155 Melanoma 21466664 MicroRNA-155 Targets the SKI Gene in Human Melanoma Cell Lines -target gene hsa-mir-214 Melanoma 21468029 miR-214 is highly expressed in human melanomas and contributes to melanoma tumour progression through suppression of TFAP2C -target gene hsa-mir-100 Endometrial Neoplasms 21472251 "hsa-mir-100 and hsa-miR-99a were predicted to target ESR1, and hsa-miR-378 and hsa-miR-768-3p to target PGR. Hsa-miR-100 was significantly down-regulated in the estrogen-dependent endometrial cancer samples as compared to the estrogen-independent samples and thus has the potential to target ESR1." -target gene hsa-mir-378a Endometrial Neoplasms 21472251 "hsa-mir-100 and hsa-miR-99a were predicted to target ESR1, and hsa-miR-378 and hsa-miR-768-3p to target PGR. Hsa-miR-100 was significantly down-regulated in the estrogen-dependent endometrial cancer samples as compared to the estrogen-independent samples and thus has the potential to target ESR1." -target gene hsa-mir-99a Endometrial Neoplasms 21472251 "hsa-mir-100 and hsa-miR-99a were predicted to target ESR1, and hsa-miR-378 and hsa-miR-768-3p to target PGR. Hsa-miR-100 was significantly down-regulated in the estrogen-dependent endometrial cancer samples as compared to the estrogen-independent samples and thus has the potential to target ESR1." -target gene hsa-mir-145 Lung Neoplasms 21479367 microRNA-145 suppresses lung adenocarcinoma-initiating cell proliferation by targeting OCT4. -target gene hsa-mir-373 "Carcinoma, Hepatocellular" 21481188 miR-373 can regulate cell cycle progression by targeting PPP6C transcripts and promotes the growth activity of hepatocellular carcinoma cells in vitro. This miRNA functions as an oncogene in hepatocellular carcinoma. -target gene hsa-mir-142 "Carcinoma, Hepatocellular" 21482222 "MicroRNA-142-3p, a new regulator of RAC1, suppresses the migration and invasion of hepatocellular carcinoma cells." -target gene hsa-mir-221 Prostate Neoplasms 21487968 MiR-221 expression affects invasion potential of human prostate carcinoma cell lines by targeting DVL2. -target gene hsa-mir-223 "Carcinoma, Hepatocellular" 21492514 microRNA-223 and its target gene oncogene c-myc have roles in hepatocellular carcinoma pathogenesis. -target gene hsa-mir-145 Lung Neoplasms 21496429 miR-145 Inhibits Lung Adenocarcinoma Stem Cells Proliferation by Targeting OCT4 Gene. -target gene hsa-mir-18a Heart Failure 21501375 MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure. -target gene hsa-mir-18b Heart Failure 21501375 MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure. -target gene hsa-mir-19a Heart Failure 21501375 MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure. -target gene hsa-mir-19b-1 Heart Failure 21501375 MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure. -target gene hsa-mir-19b-2 Heart Failure 21501375 MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure. -target gene hsa-mir-26b Breast Neoplasms 21510944 MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11. -target gene hsa-mir-143 Leukemia 21518477 "the expression of miR-143 was negatively correlated with the expression of DNMT3A mRNA, a known target gene of miR-143." -target gene hsa-mir-519d "Carcinoma, Hepatocellular" 21524841 MicroRNA-519d targets MKi67 and suppresses cell growth in the hepatocellular carcinoma cell line QGY-7703. -target gene hsa-mir-622 Gastric Neoplasms 21528065 Down-regulation of miR-622 in gastric cancer promotes cellular invasion and tumor metastasis by targeting ING1 gene. -target gene hsa-mir-200a Ovarian Neoplasms 21529905 MicroRNA-200a inhibits CD133/1+ ovarian cancer stem cells migration and invasion by targeting E-cadherin repressor ZEB2. -target gene hsa-mir-9-1 Glioblastoma 21531766 ID4 Imparts Chemoresistance and Cancer Stemness to Glioma Cells by Derepressing miR-9*-Mediated Suppression of SOX2. -target gene hsa-mir-9-2 Glioblastoma 21531766 ID4 Imparts Chemoresistance and Cancer Stemness to Glioma Cells by Derepressing miR-9*-Mediated Suppression of SOX2. -target gene hsa-mir-9-3 Glioblastoma 21531766 ID4 Imparts Chemoresistance and Cancer Stemness to Glioma Cells by Derepressing miR-9*-Mediated Suppression of SOX2. -target gene hsa-mir-101-1 "Squamous Cell Carcinoma, Head and Neck" 21532618 The tumor suppressor gene rap1GAP is silenced by miR-101-mediated EZH2 overexpression in invasive squamous cell carcinoma. -target gene hsa-mir-101-2 "Squamous Cell Carcinoma, Head and Neck" 21532618 The tumor suppressor gene rap1GAP is silenced by miR-101-mediated EZH2 overexpression in invasive squamous cell carcinoma. -target gene hsa-let-7f-1 Gastric Neoplasms 21533124 MicroRNA Let-7f Inhibits Tumor Invasion and Metastasis by Targeting MYH9 in Human Gastric Cancer. -target gene hsa-let-7f-2 Gastric Neoplasms 21533124 MicroRNA Let-7f Inhibits Tumor Invasion and Metastasis by Targeting MYH9 in Human Gastric Cancer. -target gene hsa-mir-221 Colorectal Carcinoma 21538272 MicroRNA-221 controls CDKN1C/P57 expression in human colorectal carcinoma -target gene hsa-mir-379 "Carcinoma, Hepatocellular" 21540293 Down-regulation of ABCC2 protein expression in HepG2 cells after rifampicin treatment is mediated by microRNA-379. -target gene hsa-mir-21 Colorectal Carcinoma 21546206 "This study demonstrates the inverse relationship between miR-21 and PDCD4, thus suggesting that miR-21 post-transcriptionally modulates PDCD4 via mRNA degradation. Pharmacological manipulation of the miR-21/PDCD4 axis could represent a novel therapeutic strategy in the treatment of colorectal cancer." -target gene hsa-mir-29c Esophageal Neoplasms 21551130 miR-29c induces cell cycle arrest in Esophageal Squamous Cell Carcinoma by modulating Cyclin E expression. -target gene hsa-mir-29c "Squamous Cell Carcinoma, Esophageal" 21551130 miR-29c induces cell cycle arrest in Esophageal Squamous Cell Carcinoma by modulating Cyclin E expression. -target gene hsa-mir-148a Gastric Neoplasms 21552422 miR-148a Promoted Cell Proliferation by Targeting p27 in Gastric Cancer Cells. -target gene hsa-mir-375 Gastrointestinal Neoplasms 21557705 "The genes targeted by miR-375, including JAK2 and 3'-phosphoinositide dependent protein kinase-1(PDK1), are also candidates for gastric cancer therapy" -target gene hsa-mir-146a Sepsis 21562054 MicroRNA-146a regulates both transcription silencing and translation disruption of TNF-¦Á during TLR4-induced gene reprogramming. -target gene hsa-mir-342 Colorectal Carcinoma 21565830 MicroRNA-342 Inhibits Colorectal Cancer Cell Proliferation and Invasion by Directly Targeting DNA Methyltransferase 1. -target gene hsa-mir-34a "Leukemia, Lymphocytic, Chronic, B-Cell" 21565980 Nicotinamide blocks proliferation and induces apoptosis of chronic lymphocytic leukemia cells through activation of the p53/miR-34a/SIRT1 tumor suppressor network. -target gene hsa-mir-29a "Carcinoma, Hepatocellular" 21573166 Upregulated MicroRNA-29a by Hepatitis B Virus X Protein Enhances Hepatoma Cell Migration by Targeting PTEN in Cell Culture Model. -target gene hsa-mir-150 Inflammatory Bowel Diseases 21590770 "Together, the present study presents the first evidence that miR-150 and its targeting of c-Myb may serve as a new mechanism underlying the colonic epithelial disruption in DSS-induced murine experimental colitis and in active human IBD." -target gene hsa-mir-375 Prostate Neoplasms 21593139 miRNA-375 Downregulated Sec23A protein in prostate carcinoma. -target gene hsa-mir-22 Colorectal Carcinoma 21594648 Overexpression of miR-22 reverses paclitaxel-induced chemoresistance through activation of PTEN signaling in p53-mutated colon cancer cells. -target gene hsa-let-7a Esophageal Neoplasms 21600139 "Eighteen miRNAs had their target genes, 10 of them had the potential to individually target up to 200 mRNAs. Hsa-let-7a, hsa-miR-185, hsa-miR-141, hsa-miR-92b, hsa-miR-22 and hsa-miR-301a were known as important genes associated with radioresistance." -target gene hsa-mir-141 Esophageal Neoplasms 21600139 "Eighteen miRNAs had their target genes, 10 of them had the potential to individually target up to 200 mRNAs. Hsa-let-7a, hsa-miR-185, hsa-miR-141, hsa-miR-92b, hsa-miR-22 and hsa-miR-301a were known as important genes associated with radioresistance." -target gene hsa-mir-185 Esophageal Neoplasms 21600139 "Eighteen miRNAs had their target genes, 10 of them had the potential to individually target up to 200 mRNAs. Hsa-let-7a, hsa-miR-185, hsa-miR-141, hsa-miR-92b, hsa-miR-22 and hsa-miR-301a were known as important genes associated with radioresistance." -target gene hsa-mir-22 Esophageal Neoplasms 21600139 "Eighteen miRNAs had their target genes, 10 of them had the potential to individually target up to 200 mRNAs. Hsa-let-7a, hsa-miR-185, hsa-miR-141, hsa-miR-92b, hsa-miR-22 and hsa-miR-301a were known as important genes associated with radioresistance." -target gene hsa-mir-301a Esophageal Neoplasms 21600139 "Eighteen miRNAs had their target genes, 10 of them had the potential to individually target up to 200 mRNAs. Hsa-let-7a, hsa-miR-185, hsa-miR-141, hsa-miR-92b, hsa-miR-22 and hsa-miR-301a were known as important genes associated with radioresistance." -target gene hsa-mir-92b Esophageal Neoplasms 21600139 "Eighteen miRNAs had their target genes, 10 of them had the potential to individually target up to 200 mRNAs. Hsa-let-7a, hsa-miR-185, hsa-miR-141, hsa-miR-92b, hsa-miR-22 and hsa-miR-301a were known as important genes associated with radioresistance." -target gene hsa-mir-21 Systemic Lupus Erythematosus 21602271 miR-21 regulates aberrant T cell responses through regulation of PDCD4 expression.Upregulated miR-21 affects PDCD4 expression and regulates aberrant T cell responses in human SLE. -target gene hsa-mir-372 Hepatitis B Virus Infection 21608007 MicroRNAs-372/373 promote the expression of hepatitis B Virus through the targeting of nuclear factor I/B. -target gene hsa-mir-373 Hepatitis B Virus Infection 21608007 MicroRNAs-372/373 promote the expression of hepatitis B Virus through the targeting of nuclear factor I/B. -target gene hsa-mir-146a Lymphoma 21610143 "MicroRNA-146a downregulates NF{kappa}B activity via targeting TRAF6, and functions as a tumor suppressor having strong prognostic implications in NK/T cell lymphoma." -target gene hsa-let-7a-1 Inflammation 21616524 Let-7 microRNAs inhibit IL-13 expression and represent a major regulatory mechanism for modulating IL-13 secretion in IL-13-producing cell types and thereby T(H)2 inflammation. -target gene hsa-let-7a-2 Inflammation 21616524 Let-7 microRNAs inhibit IL-13 expression and represent a major regulatory mechanism for modulating IL-13 secretion in IL-13-producing cell types and thereby T(H)2 inflammation. -target gene hsa-let-7a-3 Inflammation 21616524 Let-7 microRNAs inhibit IL-13 expression and represent a major regulatory mechanism for modulating IL-13 secretion in IL-13-producing cell types and thereby T(H)2 inflammation. -target gene hsa-let-7b Inflammation 21616524 Let-7 microRNAs inhibit IL-13 expression and represent a major regulatory mechanism for modulating IL-13 secretion in IL-13-producing cell types and thereby T(H)2 inflammation. -target gene hsa-let-7c Inflammation 21616524 Let-7 microRNAs inhibit IL-13 expression and represent a major regulatory mechanism for modulating IL-13 secretion in IL-13-producing cell types and thereby T(H)2 inflammation. -target gene hsa-let-7d Inflammation 21616524 Let-7 microRNAs inhibit IL-13 expression and represent a major regulatory mechanism for modulating IL-13 secretion in IL-13-producing cell types and thereby T(H)2 inflammation. -target gene hsa-let-7e Inflammation 21616524 Let-7 microRNAs inhibit IL-13 expression and represent a major regulatory mechanism for modulating IL-13 secretion in IL-13-producing cell types and thereby T(H)2 inflammation. -target gene hsa-let-7f-1 Inflammation 21616524 Let-7 microRNAs inhibit IL-13 expression and represent a major regulatory mechanism for modulating IL-13 secretion in IL-13-producing cell types and thereby T(H)2 inflammation. -target gene hsa-let-7f-2 Inflammation 21616524 Let-7 microRNAs inhibit IL-13 expression and represent a major regulatory mechanism for modulating IL-13 secretion in IL-13-producing cell types and thereby T(H)2 inflammation. -target gene hsa-let-7g Inflammation 21616524 Let-7 microRNAs inhibit IL-13 expression and represent a major regulatory mechanism for modulating IL-13 secretion in IL-13-producing cell types and thereby T(H)2 inflammation. -target gene hsa-let-7i Inflammation 21616524 Let-7 microRNAs inhibit IL-13 expression and represent a major regulatory mechanism for modulating IL-13 secretion in IL-13-producing cell types and thereby T(H)2 inflammation. -target gene hsa-mir-335 Breast Neoplasms 21618216 "Breast miR-335 regulates the known BRCA1 activators ER§Ø©ã IGF1R, SP1 and the repressor ID4, including a feedback regulation of miR-335 expression by estrogens. Overexpression of miR-335 resulted in an upregulation of BRCA1 mRNA expression.miR-335 affects different targets in the upstream BRCA1-regulatory cascade with impact on key cellular functions such as proliferation and apoptosis." -target gene hsa-mir-195 Cardiovascular Diseases [unspecific] 21622680 MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating Sirt1. -target gene hsa-mir-143 Pancreatic Neoplasms 21622730 "Two miRNA candidates known to be downregulated in the majority of pancreatic cancers were selected for nanovector delivery: miR-34a, which is a component of the p53 transcriptional network and regulates cancer stem cell survival, and the miR-143/145 cluster, which together repress the expression of KRAS2 and its downstream effector Ras-responsive element binding protein-1 (RREB1)." -target gene hsa-mir-145 Pancreatic Neoplasms 21622730 "Two miRNA candidates known to be downregulated in the majority of pancreatic cancers were selected for nanovector delivery: miR-34a, which is a component of the p53 transcriptional network and regulates cancer stem cell survival, and the miR-143/145 cluster, which together repress the expression of KRAS2 and its downstream effector Ras-responsive element binding protein-1 (RREB1)." -target gene hsa-mir-29a "Carcinoma, Hepatocellular" 21625215 microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer. -target gene hsa-mir-29b-1 "Carcinoma, Hepatocellular" 21625215 microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer. -target gene hsa-mir-29b-2 "Carcinoma, Hepatocellular" 21625215 microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer. -target gene hsa-mir-29c "Carcinoma, Hepatocellular" 21625215 microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer. -target gene hsa-mir-223 Gastric Neoplasms 21628394 miRNA-223 Promotes Gastric Cancer Invasion and Metastasis by Targeting Tumor Suppressor EPB41L3. -target gene hsa-mir-100 Breast Neoplasms 21634028 micro-RNA 100 Regulated beta-tubulin isotypes in MCF7 breast cancer cells. -target gene hsa-mir-100 Urinary Bladder Cancer 21636267 Reduced expression and had carcinogenic effect through targeting PLK1 protein. -target gene hsa-mir-21 Glioblastoma 21636706 Downregulation of Pdcd4 by mir-21 facilitates glioblastoma proliferation in vivo. -target gene hsa-mir-21 Inflammation 21636785 MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation. -target gene hsa-mir-100 "Leukemia, Myeloid, Acute" 21643017 "MiR-100 regulates cell differentiation and survival by targeting RBSP3, a phosphatase-like tumor suppressor in acute myeloid leukemia." -target gene hsa-mir-372 Urinary Bladder Cancer 21646351 "MicroRNA-372 Is Down-regulated and Targets Cyclin-dependent Kinase 2 (CDK2) and Cyclin A1 in Human Cervical Cancer, Which May Contribute to Tumorigenesis." -target gene hsa-mir-106a Glioblastoma 21656380 MiR-106a inhibits glioma cell growth by targeting E2F1 independent of p53 status. -target gene hsa-mir-198 "Carcinoma, Hepatocellular" 21658389 miR-198 inhibits migration and invasion of hepatocellular carcinoma cells by targeting the HGF/c-MET pathway. -target gene hsa-let-7i "Carcinoma, Hepatocellular" 21665888 "In addition, we showed that HBx up-regulated CD59 by let-7i at post-transcriptional regulation level. " -target gene hsa-mir-338 "Carcinoma, Hepatocellular" 21671467 miR-338-3p suppresses invasion of liver cancer cell by targeting smoothened. -target gene hsa-mir-192 "Carcinoma, Hepatocellular" 21672525 MiR-192 inhibits nucleotide excision repair by targeting ERCC3 and ERCC4 in HepG2.2.15 cells. -target gene hsa-mir-124-1 "Carcinoma, Hepatocellular" 21672940 The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2. -target gene hsa-mir-124-2 "Carcinoma, Hepatocellular" 21672940 The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2. -target gene hsa-mir-124-3 "Carcinoma, Hepatocellular" 21672940 The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2. -target gene hsa-mir-200c Breast Neoplasms 21682933 "Decreased expression of miRNAs of the miR-200 family has been implicated in the growth and metastasis of breast cancer cells. Of this family, miR-200c has garnered particular attention as a consequence of its ability to target ZEB1 and ZEB2, mediators of epithelial- mesenchymal transition." -target gene hsa-mir-9-1 Cardiovascular Diseases [unspecific] 21684288 MicroRNA-9 is an activation-induced regulator of PDGFR-beta expression in cardiomyocytes. -target gene hsa-mir-9-2 Cardiovascular Diseases [unspecific] 21684288 MicroRNA-9 is an activation-induced regulator of PDGFR-beta expression in cardiomyocytes. -target gene hsa-mir-9-3 Cardiovascular Diseases [unspecific] 21684288 MicroRNA-9 is an activation-induced regulator of PDGFR-beta expression in cardiomyocytes. -target gene hsa-mir-99a Psoriasis 21687694 differentially expressed. miR-99a is one of the regulators of the IGF-1R signaling pathway in keratinocytes. Activation of IGF1 signaling results in elevation of miR-99a which represses the expression of IGF-1R. -target gene hsa-mir-214 Gastric Neoplasms 21688200 Down-Regulated miRNA-214 Induces a Cell Cycle G1 Arrest in Gastric Cancer Cells by Up-Regulating the PTEN Protein. -target gene hsa-mir-340 Breast Neoplasms 21692045 miR-340 inhibites breast cancer cell migration and invasion through targeting of oncoprotein c-Met. -target gene hsa-mir-130a "Carcinoma, Lung, Non-Small-Cell" 21706050 miR-130a targets MET and induces TRAIL-sensitivity in NSCLC by downregulating miR-221 and 222. -target gene hsa-mir-221 "Carcinoma, Lung, Non-Small-Cell" 21706050 miR-130a targets MET and induces TRAIL-sensitivity in NSCLC by downregulating miR-221 and 222. -target gene hsa-mir-222 "Carcinoma, Lung, Non-Small-Cell" 21706050 miR-130a targets MET and induces TRAIL-sensitivity in NSCLC by downregulating miR-221 and 222. -target gene hsa-mir-155 Intervertebral Disc Degeneration 21706480 Deregulated miR-155 promotes Fas-mediated apoptosis in human intervertebral disc degeneration by targeting FADD and caspase-3. -target gene hsa-mir-23a Ischemia 21709246 miR-23a regulation of X-linked inhibitor of apoptosis (XIAP) contributes to sex differences in the response to cerebral ischemia. -target gene hsa-mir-148a Pancreatic Neoplasms 21709669 MicroRNA-148a is down-regulated in human pancreatic ductal adenocarcinomas and regulates cell survival by targeting CDC25B. -target gene hsa-mir-488 Prostate Neoplasms 21710544 miR 488* inhibits androgen receptor expression in prostate carcinoma cells. -target gene hsa-mir-302a Glioblastoma 21720384 The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network. -target gene hsa-mir-302b Glioblastoma 21720384 The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network. -target gene hsa-mir-302c Glioblastoma 21720384 The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network. -target gene hsa-mir-302d Glioblastoma 21720384 The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network. -target gene hsa-mir-367 Glioblastoma 21720384 The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network. -target gene hsa-mir-181c Alzheimer Disease 21720722 "Taken together, our study identifies putative target genes of miRNAs miR-9 and 181c, which may function in brain homeostasis and disease pathogenesis." -target gene hsa-mir-9 Alzheimer Disease 21720722 "Taken together, our study identifies putative target genes of miRNAs miR-9 and 181c, which may function in brain homeostasis and disease pathogenesis." -target gene hsa-mir-193b "Leukemia, Myeloid, Acute" 21724256 MicroRNA-193b regulates c-Kit proto-oncogene and represses cell proliferation in acute myeloid leukemia. -target gene hsa-mir-187 Ovarian Neoplasms 21725366 microRNA-187 Regulates of ovarian cancer progression through targeting Disabled homolog-2. -target gene hsa-mir-15b Tongue Neoplasms 21725369 MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1. -target gene hsa-mir-200b Tongue Neoplasms 21725369 MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1. -target gene hsa-mir-122 "Carcinoma, Hepatocellular" 21725618 miR-122 inhibits viral replication and cell proliferation in hepatitis B virus-related hepatocellular carcinoma and targets NDRG3. -target gene hsa-mir-206 Myocardial Infarction 21731608 "HMGB1 injected into chronically failing hearts enhanced LV function and attenuated LV remodelling; these effects were associated with cardiac regeneration, increased collagenolytic activity, miR-206 overexpression and miR-206 -mediated inhibition of TIMP-3." -target gene hsa-mir-10 Pancreatic Neoplasms 21738581 Predicted target mRNAs FGFR1 (miR-10) and MLH1 (miR-155) were found downregulated. -target gene hsa-mir-155 Pancreatic Neoplasms 21738581 Predicted target mRNAs FGFR1 (miR-10) and MLH1 (miR-155) were found downregulated. -target gene hsa-mir-34a Glioblastoma 21743299 MicroRNA-34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme. -target gene hsa-mir-221 Glioblastoma 21743492 miR-221/222 overexpession in human glioblastoma increases invasiveness by targeting the protein phosphate PTP mu. -target gene hsa-mir-222 Glioblastoma 21743492 miR-221/222 overexpession in human glioblastoma increases invasiveness by targeting the protein phosphate PTP mu. -target gene hsa-mir-7-1 "Carcinoma, Lung, Non-Small-Cell" 21750649 MicroRNA-7 inhibits the growth of human non-small cell lung cancer A549 cells through targeting BCL-2. -target gene hsa-mir-7-2 "Carcinoma, Lung, Non-Small-Cell" 21750649 MicroRNA-7 inhibits the growth of human non-small cell lung cancer A549 cells through targeting BCL-2. -target gene hsa-mir-7-3 "Carcinoma, Lung, Non-Small-Cell" 21750649 MicroRNA-7 inhibits the growth of human non-small cell lung cancer A549 cells through targeting BCL-2. -target gene hsa-mir-1-1 Thyroid Neoplasms 21752897 "MiR-1 suppress Thyroid Cancer by Targeting CCND2, CXCR4, and SDF-1{alpha}" -target gene hsa-mir-1-2 Thyroid Neoplasms 21752897 "MiR-1 suppress Thyroid Cancer by Targeting CCND2, CXCR4, and SDF-1{alpha}" -target gene hsa-mir-375 "Squamous Cell Carcinoma, Head and Neck" 21753766 Tumor suppressive microRNA-375 regulates oncogene AEG-1/MTDH in head and neck squamous cell carcinoma (HNSCC). -target gene hsa-mir-21 Breast Neoplasms 21761201 "3,3'-Diindolylmethane inhibits breast cancer cell growth via miR-21-mediated Cdc25A degradation." -target gene hsa-mir-29c "Carcinoma, Hepatocellular" 21763284 "miR-29c targets TNFAIP3, inhibits cell proliferation and induces apoptosis in hepatitis B virus-related hepatocellular carcinoma." -target gene hsa-mir-106a Breast Neoplasms 21765466 "The experimental results using MDA-MB-231 and MCF-7 human breast cancer cells confirm that miRNAs derived from these clusters, containing miR-17-5p, miR-20a, miR-106a, miR-106b and miR-93, negatively regulate ZBTB4 expression." -target gene hsa-mir-106b Breast Neoplasms 21765466 "The experimental results using MDA-MB-231 and MCF-7 human breast cancer cells confirm that miRNAs derived from these clusters, containing miR-17-5p, miR-20a, miR-106a, miR-106b and miR-93, negatively regulate ZBTB4 expression." -target gene hsa-mir-17 Breast Neoplasms 21765466 "The experimental results using MDA-MB-231 and MCF-7 human breast cancer cells confirm that miRNAs derived from these clusters, containing miR-17-5p, miR-20a, miR-106a, miR-106b and miR-93, negatively regulate ZBTB4 expression." -target gene hsa-mir-20a Breast Neoplasms 21765466 "The experimental results using MDA-MB-231 and MCF-7 human breast cancer cells confirm that miRNAs derived from these clusters, containing miR-17-5p, miR-20a, miR-106a, miR-106b and miR-93, negatively regulate ZBTB4 expression." -target gene hsa-mir-93 Breast Neoplasms 21765466 "The experimental results using MDA-MB-231 and MCF-7 human breast cancer cells confirm that miRNAs derived from these clusters, containing miR-17-5p, miR-20a, miR-106a, miR-106b and miR-93, negatively regulate ZBTB4 expression." -target gene hsa-mir-133a-1 Hypertension 21769867 "MiR-133a regulates collagen 1A1, which has potential role in myocardial fibrosis in angiotensin II dependent hypertension." -target gene hsa-mir-133a-2 Hypertension 21769867 "MiR-133a regulates collagen 1A1, which has potential role in myocardial fibrosis in angiotensin II dependent hypertension." -target gene hsa-mir-125a Lung Neoplasms 21777146 MicroRNA HSA-miR-125a-5p induces apoptosis by activating p53 in lung cancer cells. -target gene hsa-mir-143 Urinary Bladder Cancer 21790228 Expression of miR-143 Reduces Growth and Migration of Human Bladder Carcinoma Cells by Targeting Cyclooxygenase-2. -target gene hsa-mir-29b-1 "Carcinoma, Hepatocellular" 21793034 "MicroRNA-29b suppresses tumor angiogenesis, invasion and metastasis by regulating MMP-2 expression." -target gene hsa-mir-29b-2 "Carcinoma, Hepatocellular" 21793034 "MicroRNA-29b suppresses tumor angiogenesis, invasion and metastasis by regulating MMP-2 expression." -target gene hsa-mir-218-1 "Squamous Cell Carcinoma, Oral" 21795477 The tumor suppressive microRNA miR-218 targets the mTOR component Rictor and inhibits AKT phosphorylation in oral cancer. -target gene hsa-mir-218-2 "Squamous Cell Carcinoma, Oral" 21795477 The tumor suppressive microRNA miR-218 targets the mTOR component Rictor and inhibits AKT phosphorylation in oral cancer. -target gene hsa-mir-17 Neuroblastoma 21796614 Dickkopf-3 is regulated by the MYCN-induced miR-17-92 cluster in neuroblastoma -target gene hsa-mir-18a Neuroblastoma 21796614 Dickkopf-3 is regulated by the MYCN-induced miR-17-92 cluster in neuroblastoma -target gene hsa-mir-19a Neuroblastoma 21796614 Dickkopf-3 is regulated by the MYCN-induced miR-17-92 cluster in neuroblastoma -target gene hsa-mir-19b-1 Neuroblastoma 21796614 Dickkopf-3 is regulated by the MYCN-induced miR-17-92 cluster in neuroblastoma -target gene hsa-mir-20a Neuroblastoma 21796614 Dickkopf-3 is regulated by the MYCN-induced miR-17-92 cluster in neuroblastoma -target gene hsa-mir-92a-1 Neuroblastoma 21796614 Dickkopf-3 is regulated by the MYCN-induced miR-17-92 cluster in neuroblastoma -target gene hsa-mir-210 Preeclampsia 21801864 miR-210 Targets Iron-Sulfur Cluster Scaffold Homologue -target gene hsa-mir-491 Hepatitis C Virus Infection 21802413 miR-491 was involved in regulation of HCV replication via the PI3 kinase/Akt pathway. -target gene hsa-mir-122 "Carcinoma, Hepatocellular" 21802841 MicroRNA-122 sensitizes HCC cancer cells to adriamycin and vincristine through modulating expression of MDR and inducing cell cycle arrest. -target gene hsa-mir-199a-1 "Carcinoma, Hepatocellular" 21807947 MicroRNA miR-199a-3p regulates cell proliferation and survival by targeting caveolin-2. -target gene hsa-mir-199a-1 Urinary Bladder Cancer 21807947 MicroRNA miR-199a-3p regulates cell proliferation and survival by targeting caveolin-2. -target gene hsa-mir-199a-2 "Carcinoma, Hepatocellular" 21807947 MicroRNA miR-199a-3p regulates cell proliferation and survival by targeting caveolin-2. -target gene hsa-mir-199a-2 Urinary Bladder Cancer 21807947 MicroRNA miR-199a-3p regulates cell proliferation and survival by targeting caveolin-2. -target gene hsa-mir-147 Dengue Virus Infection 21810247 "a microRNA which may negatively regulate pro-inflammatory cytokines in dengue infected peripheral blood cells, mIR-147 (NMES1)." -target gene hsa-mir-375 "Squamous Cell Carcinoma, Esophageal" 21813472 MicroRNA-375 inhibits tumour growth and metastasis in oesophageal squamous cell carcinoma through repressing insulin-like growth factor 1 receptor. -target gene hsa-mir-34a Breast Neoplasms 21814748 Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR-34a microRNA. -target gene hsa-mir-106b Laryngeal Neoplasms 21819631 MiR-106b promotes cell proliferation via targeting RB in laryngeal carcinoma. -target gene hsa-mir-21 "Carcinoma, Renal Cell" 21820586 miR-21 Modulates Cell Apoptosis by Targeting Multiple Genes in Renal Cell Carcinoma. -target gene hsa-mir-21 Breast Neoplasms 21820606 MicroRNA-21 Modulates Chemosensitivity of Breast Cancer Cells to Doxorubicin by Targeting PTEN. -target gene hsa-mir-335 Gastric Neoplasms 21822301 MicroRNA-335 acts as a metastasis suppressor in gastric cancer by targeting Bcl-w and specificity protein 1. -target gene hsa-mir-146b Pancreatic Neoplasms 21823013 miR-146b-5p has inhibitory effects of on cell migration and invasion of pancreatic cancer by targeting MMP16. -target gene hsa-mir-125b-1 Ovarian Neoplasms 21823019 miR-125b confers resistance of ovarian cancer cells to cisplatin by targeting pro-apoptotic Bcl-2 antagonist killer 1. -target gene hsa-mir-125b-2 Ovarian Neoplasms 21823019 miR-125b confers resistance of ovarian cancer cells to cisplatin by targeting pro-apoptotic Bcl-2 antagonist killer 1. -target gene hsa-mir-21 Prostate Neoplasms 21826097 Spry1 is a target for miR-21-mediated gene silencing. -target gene hsa-mir-451a Diabetic Nephropathy 21827757 MicroRNA-451 regulates p38 MAPK signaling by targeting of Ywhaz and suppresses the mesangial hypertrophy in early Diabetic Nephropathies. -target gene hsa-let-7e Ischemia-Reperfusion Injury 21827835 MicroRNA let-7e regulates the expression of caspase-3 during apoptosis of PC12 cells following anoxia/reoxygenation injury. -target gene hsa-mir-144 "Diabetes Mellitus, Type 2" 21829658 MicroRNA 144 Impairs Insulin Signaling by Inhibiting the Expression of Insulin Receptor Substrate 1 in Type 2 Diabetes Mellitus. -target gene hsa-mir-107 Breast Neoplasms 21841313 miR-107 promotes tumor progression by targeting the let-7 microRNA in mice and humans. -target gene hsa-mir-194-1 Endometrial Neoplasms 21851624 MicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting oncogene BMI-1. -target gene hsa-mir-194-2 Endometrial Neoplasms 21851624 MicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting oncogene BMI-1. -target gene hsa-let-7a-1 Ewing Sarcoma 21853155 Let-7a Is a Direct EWS-FLI-1 Target Implicated in Ewing's Sarcoma Development. -target gene hsa-let-7a-2 Ewing Sarcoma 21853155 Let-7a Is a Direct EWS-FLI-1 Target Implicated in Ewing's Sarcoma Development. -target gene hsa-let-7a-3 Ewing Sarcoma 21853155 Let-7a Is a Direct EWS-FLI-1 Target Implicated in Ewing's Sarcoma Development. -target gene hsa-mir-375 Lung Neoplasms 21856745 miR-375 is activated by ASH1 and inhibits YAP1 in a lineage dependent manner in lung cancer. -target gene hsa-mir-9-1 Glioblastoma 21857646 CAMTA1 is a novel tumour suppressor regulated by miR-9/9(*) in glioblastoma stem cells. -target gene hsa-mir-9-2 Glioblastoma 21857646 CAMTA1 is a novel tumour suppressor regulated by miR-9/9(*) in glioblastoma stem cells. -target gene hsa-mir-9-3 Glioblastoma 21857646 CAMTA1 is a novel tumour suppressor regulated by miR-9/9(*) in glioblastoma stem cells. -target gene hsa-mir-494 Urinary Bladder Cancer 21859890 miR-494 Competitively regulates Nucleolin expression with HuR. -target gene hsa-mir-542 Neoplasms [unspecific] 21860426 downregulation of miR-542-3p is significantly correlated with the upregulation of c-Src and ILK. Our results suggest that the novel c-Src-miR-542-3p-ILK-FAK circuit plays a crucial role in controlling tumor progression. -target gene hsa-mir-221 Breast Neoplasms 21868360 miR-221/222 Targeting of Trichorhinophalangeal 1 (TRPS1) Promotes Epithelial-to-Mesenchymal Transition in Breast Cancer. -target gene hsa-mir-222 Breast Neoplasms 21868360 miR-221/222 Targeting of Trichorhinophalangeal 1 (TRPS1) Promotes Epithelial-to-Mesenchymal Transition in Breast Cancer. -target gene hsa-let-7a-1 Mesothelioma 21869823 "EphrinA1 inhibits malignant mesothelioma tumor growth via let-7 microRNA-mediated repression of the RAS oncogene.EphrinA1 activation induced several fold increases in let-7a1, let-7a3, let-7f1 and let-7f2 miRNA expression in MMCs." -target gene hsa-let-7a-3 Mesothelioma 21869823 "EphrinA1 inhibits malignant mesothelioma tumor growth via let-7 microRNA-mediated repression of the RAS oncogene.EphrinA1 activation induced several fold increases in let-7a1, let-7a3, let-7f1 and let-7f2 miRNA expression in MMCs." -target gene hsa-let-7f-1 Mesothelioma 21869823 "EphrinA1 inhibits malignant mesothelioma tumor growth via let-7 microRNA-mediated repression of the RAS oncogene.EphrinA1 activation induced several fold increases in let-7a1, let-7a3, let-7f1 and let-7f2 miRNA expression in MMCs." -target gene hsa-let-7f-2 Mesothelioma 21869823 "EphrinA1 inhibits malignant mesothelioma tumor growth via let-7 microRNA-mediated repression of the RAS oncogene.EphrinA1 activation induced several fold increases in let-7a1, let-7a3, let-7f1 and let-7f2 miRNA expression in MMCs." -target gene hsa-mir-140 Osteoarthritis 21872590 MiR-140 is co-expressed with Wwp2-C transcript and activated by Sox9 to target Sp1 in maintaining the chondrocyte proliferation. -target gene hsa-mir-21 Colorectal Carcinoma 21872591 "miR-21 targets the tumor suppressor RhoB and regulates proliferation, invasion and apoptosis in colorectal cancer cells." -target gene hsa-mir-146b Thyroid Neoplasms 21874046 MicroRNA miR-146b-5p regulates signal transduction of TGF-beta by repressing SMAD4 in thyroid cancer. -target gene hsa-mir-216b Nasopharyngeal Neoplasms 21878506 miR-216b suppresses tumor growth and invasion by targeting KRAS in nasopharyngeal carcinoma. -target gene hsa-mir-98 "Carcinoma, Lung, Non-Small-Cell" 21880462 miR-98 regulates cisplatin-induced A549 cell death by inhibiting TP53 pathway. -target gene hsa-mir-125b-1 Huntington Disease 21887328 "The authors conclude that (i) miR-125b and miR-150 target p53, which in turn regulates RelA/NFkB and miR-146a expressions; (ii) reduced miR-125b and miR-150 expressions, increased p53 level and decreased RelA/NFkB and miR-146a expressions originate from mutant HTT (iii) p53 directly or indirectly regulates the expression of miR-146a." -target gene hsa-mir-125b-2 Huntington Disease 21887328 "The authors conclude that (i) miR-125b and miR-150 target p53, which in turn regulates RelA/NFkB and miR-146a expressions; (ii) reduced miR-125b and miR-150 expressions, increased p53 level and decreased RelA/NFkB and miR-146a expressions originate from mutant HTT (iii) p53 directly or indirectly regulates the expression of miR-146a." -target gene hsa-mir-146a Huntington Disease 21887328 "The authors conclude that (i) miR-125b and miR-150 target p53, which in turn regulates RelA/NFkB and miR-146a expressions; (ii) reduced miR-125b and miR-150 expressions, increased p53 level and decreased RelA/NFkB and miR-146a expressions originate from mutant HTT (iii) p53 directly or indirectly regulates the expression of miR-146a." -target gene hsa-mir-150 Huntington Disease 21887328 "The authors conclude that (i) miR-125b and miR-150 target p53, which in turn regulates RelA/NFkB and miR-146a expressions; (ii) reduced miR-125b and miR-150 expressions, increased p53 level and decreased RelA/NFkB and miR-146a expressions originate from mutant HTT (iii) p53 directly or indirectly regulates the expression of miR-146a." -target gene hsa-mir-423 "Carcinoma, Hepatocellular" 21890460 MicroRNA-423 Promotes Cell Growth and Regulates G1/S Transition by Targeting p21Cip1/Waf1 in Hepatocellular Carcinoma -target gene hsa-mir-193b Melanoma 21893020 "miR-193b is expressed at a significantly lower level in malignant melanoma than in benign nevi. In a survey of melanoma samples, the level of Mcl-1 is inversely correlated with the level of miR-193b. Overexpression of miR-193b in melanoma cells represses Mcl-1 expression. Furthermore, the effect of miR-193b on the expression of Mcl-1 seems to be mediated by direct interaction between miR-193b and seed and seedless pairing sequences in the 3' untranslated region of Mcl-1 mRNA." -target gene hsa-mir-373 Fibrosarcoma 21898400 miR-520c and miR-373 increased the expression of MMP9 by directly targeting the 3'UTRs of mRNAs of mTOR and SIRT1 and suppressing their translation; resulting in activation of the Ras/Raf/MEK/Erk signaling pathway and NF-§Ø¨mB; and finally increasing the mRN -target gene hsa-mir-520c Fibrosarcoma 21898400 miR-520c and miR-373 increased the expression of MMP9 by directly targeting the 3'UTRs of mRNAs of mTOR and SIRT1 and suppressing their translation; resulting in activation of the Ras/Raf/MEK/Erk signaling pathway and NF-§Ø¨mB; and finally increasing the mRN -target gene hsa-mir-200c Head And Neck Neoplasms 21899661 "The expression of ZEB1, a target mRNA for miR-200c, was up-regulated 3 and 6 hours after HGF stimulation." -target gene hsa-mir-200c "Squamous Cell Carcinoma, Head and Neck" 21899661 "The expression of ZEB1, a target mRNA for miR-200c, was up-regulated 3 and 6 hours after HGF stimulation." -target gene hsa-mir-27b Head And Neck Neoplasms 21899661 "The expression of ST14/matriptase an enzyme for extracellular matrix (ECM) degradation and HGF activation and a target mRNA for miR-27b, was drastically up-regulated in protein level after HGF stimulation." -target gene hsa-mir-27b "Squamous Cell Carcinoma, Head and Neck" 21899661 "The expression of ST14/matriptase an enzyme for extracellular matrix (ECM) degradation and HGF activation and a target mRNA for miR-27b, was drastically up-regulated in protein level after HGF stimulation." -target gene hsa-let-7i Coronary Artery Disease 21899916 "This study suggests that atorvastatin down-regulates TLR4 signal via let-7i expression in CAD patients, possibly contributing to the beneficial effects of atorvastatin on let-7i-mediated TLR4 signal in this disorder." -target gene hsa-mir-26b Lung Neoplasms 21901137 "Expression of miR-26b was down regulated, and its target activating transcription factor 2 (ATF2) mRNA was up regulated in §Ø©ãirradiated H1299 cells." -target gene hsa-mir-224 "Carcinoma, Renal Cell" 21912701 MiR-224 Targets the 3'UTR of Type 1 5'-Iodothyronine Deiodinase Possibly Contributing to Tissue Hypothyroidism in Renal Cancer. -target gene hsa-mir-145 Colon Neoplasms 21917858 The expression of miR-145 is downregulated in colon and ovarian cancer tissues and cell lines. MiR-145 directly targets p70S6K1 in cancer cells to inhibit tumor growth and angiogenesis. -target gene hsa-mir-145 Ovarian Neoplasms 21917858 The expression of miR-145 is downregulated in colon and ovarian cancer tissues and cell lines. MiR-145 directly targets p70S6K1 in cancer cells to inhibit tumor growth and angiogenesis. -target gene hsa-mir-1-1 Laryngeal Neoplasms 21924268 miRNA-1 targets fibronectin1 and suppresses the migration and invasion of the HEp2 laryngeal squamous carcinoma cell line. -target gene hsa-mir-1-1 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 21924268 miRNA-1 targets fibronectin1 and suppresses the migration and invasion of the HEp2 laryngeal squamous carcinoma cell line. -target gene hsa-mir-1-2 Laryngeal Neoplasms 21924268 miRNA-1 targets fibronectin1 and suppresses the migration and invasion of the HEp2 laryngeal squamous carcinoma cell line. -target gene hsa-mir-1-2 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 21924268 miRNA-1 targets fibronectin1 and suppresses the migration and invasion of the HEp2 laryngeal squamous carcinoma cell line. -target gene hsa-mir-200a Breast Neoplasms 21926171 miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells. -target gene hsa-mir-23a Muscular Dystrophy 21926429 miR-23a suppresses the translation of both MAFbx/atrogin-1 and MuRF1 in a 3UTR-dependent manner. Ectopic expression of miR-23a is sufficient to protect muscles from atrophy in vitro and in vivo. -target gene hsa-mir-504 "Squamous Cell Carcinoma, Oral" 21927029 Connective tissue growth factor modulates oral squamous cell carcinoma invasion by activating a miR-504/FOXP1 signalling. -target gene hsa-mir-34a Medulloblastoma 21931765 MiR-34a Targeting of Notch Ligand Delta-Like 1 Impairs CD15/CD133 Tumor-Propagating Cells and Supports Neural Differentiation in Medulloblastoma. -target gene hsa-mir-499a Colorectal Carcinoma 21934092 microRNA-499-5p promotes cellular invasion and tumor metastasis in colorectal cancer by targeting FOXO4 and PDCD4. -target gene hsa-mir-18a Urinary Bladder Cancer 21935572 "microRNA-18a, a member of the oncogenic miR-17-92 cluster, targets Dicer and suppresses cell proliferation in bladder cancer T24 cells." -target gene hsa-mir-375 Urinary Bladder Cancer 21945323 "miR-375, Down-Regulated in Squamous Cervical Cancer, Inhibits Cell Migration and Invasion via Targeting Transcription Factor SP1." -target gene hsa-mir-145 Atherosclerosis 21945499 We showed that miR-145 can regulate the fate and phenotype of human ES-pre-SMCs as they become fully differentiated SMCs. -target gene hsa-mir-195 "Carcinoma, Hepatocellular" 21947305 miRNA-195 sensitizes human hepatocellular carcinoma cells to 5-FU by targeting BCL-w. -target gene hsa-mir-191 Gastric Neoplasms 21947487 MicroRNA-191 targets N-deacetylase/N-sulfotransferase 1 and promotes cell growth in human gastric carcinoma cell line MGC803. -target gene hsa-mir-29b-1 Multiple Myeloma 21951844 Overexpression of microRNA-29b induces apoptosis of multiple myeloma cells through down regulating Mcl-1. -target gene hsa-mir-25 Cholangiocarcinoma 21953056 miR-25 targets TRAIL death Receptor-4 and promotes apoptosis resistance in cholangiocarcinoma. -target gene hsa-mir-128-1 Breast Neoplasms 21953503 Reduced miR-128 in breast tumor-initiating cells induces chemotherapeutic resistance via Bmi-1 and ABCC5. -target gene hsa-mir-106a "Lymphoma, Hodgkin" 21953646 MiR-17/106b seed family regulates p21 in Hodgkin's lymphoma. -target gene hsa-mir-106b "Lymphoma, Hodgkin" 21953646 MiR-17/106b seed family regulates p21 in Hodgkin's lymphoma. -target gene hsa-mir-17 "Lymphoma, Hodgkin" 21953646 MiR-17/106b seed family regulates p21 in Hodgkin's lymphoma. -target gene hsa-mir-191 Thyroid Neoplasms 21956418 miR-191 Down-Regulation Plays a Role in Thyroid Follicular Tumors through CDK6 Targeting. -target gene hsa-mir-135a-1 Endometriosis 21956427 miR-135a Regulates HOXA10 Expression in Endometriosis. -target gene hsa-mir-135a-2 Endometriosis 21956427 miR-135a Regulates HOXA10 Expression in Endometriosis. -target gene hsa-mir-135b Endometriosis 21956427 miR-135b Regulates HOXA10 Expression in Endometriosis. -target gene hsa-mir-93 Osteosarcoma 21959981 "Levels of miR-93 were significantly higher in metastases from osteosarcoma than in paired primary tumours. When 143B and MG-63 were transfected with miR-93, clones appeared to respond differently to microRNA overexpression. Ectopic expression of miR-93 more significantly increased cell proliferation and invasivity in 143B than in MG-63 clones. Furthermore, increased mRNA and protein levels of E2F1, one of the potential miR-93 targets, were seen in osteosarcoma cellular clones and its involvement in 143B cell proliferation was confirmed by E2F1 silencing." -target gene hsa-mir-125b-1 Endometrial Neoplasms 21970405 MiR-125b promotes proliferation and migration of type II endometrial carcinoma cells through targeting TP53INP1 tumor suppressor in vitro and in vivo. -target gene hsa-mir-125b-2 Endometrial Neoplasms 21970405 MiR-125b promotes proliferation and migration of type II endometrial carcinoma cells through targeting TP53INP1 tumor suppressor in vitro and in vivo. -target gene hsa-mir-142 "Leukemia-Lymphoma, Adult T-Cell" 21979877 miR-142-3p plans an oncogenic role in human T-cell acute lymphoblastic leukemia (T-ALL) by targeting glucocorticoid receptor-§Ø©ãand cAMP/PKA pathways. -target gene hsa-mir-150 Pancreatic Neoplasms 21983127 MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells. -target gene hsa-mir-181a-2 Ischemia 21983159 miR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo. -target gene hsa-mir-1293 Kaposi Sarcoma 21984125 "We show a direct repression of vIL-6 by hsa-miR-1293 and hIL-6 by hsa-miR-608. The repression of vIL-6 by miR-1293 was reversed by disruption of the vIL-6 miR-1293 seed match through the introduction of point mutations. In addition, expression of vIL-6 or" -target gene hsa-mir-608 Kaposi Sarcoma 21984125 "We show a direct repression of vIL-6 by hsa-miR-1293 and hIL-6 by hsa-miR-608. The repression of vIL-6 by miR-1293 was reversed by disruption of the vIL-6 miR-1293 seed match through the introduction of point mutations. In addition, expression of vIL-6 or" -target gene hsa-let-7c Colorectal Carcinoma 21984339 Let-7c functions as a metastasis suppressor by targeting MMP11 and PBX3 in colorectal cancer. -target gene hsa-mir-24-1 Breast Neoplasms 21986943 miR-24 was found to be implicated in the regulation of the EMT program in response to TGF-beta and was shown to be directly involved in the TGF-§Ø©ãinduced breast cancer cell invasiveness through Net1A regulation. -target gene hsa-mir-24-2 Breast Neoplasms 21986943 miR-24 was found to be implicated in the regulation of the EMT program in response to TGF-beta and was shown to be directly involved in the TGF-§Ø©ãinduced breast cancer cell invasiveness through Net1A regulation. -target gene hsa-mir-199a-1 Endometriosis 21989168 MiR-199a attenuates endometrial stromal cell invasiveness through suppression of the IKK{beta}/NF-kB pathway and reduced interleukin-8 expression. -target gene hsa-mir-199a-2 Endometriosis 21989168 MiR-199a attenuates endometrial stromal cell invasiveness through suppression of the IKK{beta}/NF-kB pathway and reduced interleukin-8 expression. -target gene hsa-mir-155 "Carcinoma, Hepatocellular" 21989846 Aberrant expression of microRNA 155 may accelerate cell proliferation by targeting sex-determining region Y box 6 in hepatocellular carcinoma. -target gene hsa-mir-200b "Carcinoma, Lung, Non-Small-Cell" 21993663 miR-200bc/429 cluster modulates multidrug resistance of human cancer cell lines by targeting BCL2 and XIAP. -target gene hsa-mir-200b Gastric Neoplasms 21993663 miR-200bc/429 cluster modulates multidrug resistance of human cancer cell lines by targeting BCL2 and XIAP. -target gene hsa-mir-200c "Carcinoma, Lung, Non-Small-Cell" 21993663 miR-200bc/429 cluster modulates multidrug resistance of human cancer cell lines by targeting BCL2 and XIAP. -target gene hsa-mir-200c Gastric Neoplasms 21993663 miR-200bc/429 cluster modulates multidrug resistance of human cancer cell lines by targeting BCL2 and XIAP. -target gene hsa-mir-429 "Carcinoma, Lung, Non-Small-Cell" 21993663 miR-200bc/429 cluster modulates multidrug resistance of human cancer cell lines by targeting BCL2 and XIAP. -target gene hsa-mir-429 Gastric Neoplasms 21993663 miR-200bc/429 cluster modulates multidrug resistance of human cancer cell lines by targeting BCL2 and XIAP. -target gene hsa-mir-148a Gastric Neoplasms 21994419 MicroRNA-148a Suppresses Tumor Cell Invasion and Metastasis by Downregulating ROCK1 in Gastric Cancer. -target gene hsa-mir-1-1 Chronic Obstructive Pulmonary Disease 21998125 "A reduction in expression of miR-1 (2.5-fold, p=0.01) and the myocardin-related transcription factors (MRTFs) A and B was observed in patients compared with controls (MRTF-A mRNA: twofold, p=0.028; MRTF-B mRNA: fourfold, p=0.011). miR-1 expression was associated with smoking history, lung function, fat-free mass index, 6 min walk distance and percentage of type 1 fibres. miR-133 and miR-206 were negatively correlated with daily physical activity. Insulin-like growth factor 1 mRNA was increased in the patients and miR-1 was negatively correlated with phosphorylation of the kinase Akt. Furthermore, the protein levels of histone deacetylase 4, another miR-1 target, were increased in the patients." -target gene hsa-mir-1-2 Chronic Obstructive Pulmonary Disease 21998125 "A reduction in expression of miR-1 (2.5-fold, p=0.01) and the myocardin-related transcription factors (MRTFs) A and B was observed in patients compared with controls (MRTF-A mRNA: twofold, p=0.028; MRTF-B mRNA: fourfold, p=0.011). miR-1 expression was associated with smoking history, lung function, fat-free mass index, 6 min walk distance and percentage of type 1 fibres. miR-133 and miR-206 were negatively correlated with daily physical activity. Insulin-like growth factor 1 mRNA was increased in the patients and miR-1 was negatively correlated with phosphorylation of the kinase Akt. Furthermore, the protein levels of histone deacetylase 4, another miR-1 target, were increased in the patients." -target gene hsa-mir-133a-1 Chronic Obstructive Pulmonary Disease 21998125 "A reduction in expression of miR-1 (2.5-fold, p=0.01) and the myocardin-related transcription factors (MRTFs) A and B was observed in patients compared with controls (MRTF-A mRNA: twofold, p=0.028; MRTF-B mRNA: fourfold, p=0.011). miR-1 expression was associated with smoking history, lung function, fat-free mass index, 6 min walk distance and percentage of type 1 fibres. miR-133 and miR-206 were negatively correlated with daily physical activity. Insulin-like growth factor 1 mRNA was increased in the patients and miR-1 was negatively correlated with phosphorylation of the kinase Akt. Furthermore, the protein levels of histone deacetylase 4, another miR-1 target, were increased in the patients." -target gene hsa-mir-133a-2 Chronic Obstructive Pulmonary Disease 21998125 "A reduction in expression of miR-1 (2.5-fold, p=0.01) and the myocardin-related transcription factors (MRTFs) A and B was observed in patients compared with controls (MRTF-A mRNA: twofold, p=0.028; MRTF-B mRNA: fourfold, p=0.011). miR-1 expression was associated with smoking history, lung function, fat-free mass index, 6 min walk distance and percentage of type 1 fibres. miR-133 and miR-206 were negatively correlated with daily physical activity. Insulin-like growth factor 1 mRNA was increased in the patients and miR-1 was negatively correlated with phosphorylation of the kinase Akt. Furthermore, the protein levels of histone deacetylase 4, another miR-1 target, were increased in the patients." -target gene hsa-mir-133b Chronic Obstructive Pulmonary Disease 21998125 "A reduction in expression of miR-1 (2.5-fold, p=0.01) and the myocardin-related transcription factors (MRTFs) A and B was observed in patients compared with controls (MRTF-A mRNA: twofold, p=0.028; MRTF-B mRNA: fourfold, p=0.011). miR-1 expression was associated with smoking history, lung function, fat-free mass index, 6 min walk distance and percentage of type 1 fibres. miR-133 and miR-206 were negatively correlated with daily physical activity. Insulin-like growth factor 1 mRNA was increased in the patients and miR-1 was negatively correlated with phosphorylation of the kinase Akt. Furthermore, the protein levels of histone deacetylase 4, another miR-1 target, were increased in the patients." -target gene hsa-mir-206 Chronic Obstructive Pulmonary Disease 21998125 "A reduction in expression of miR-1 (2.5-fold, p=0.01) and the myocardin-related transcription factors (MRTFs) A and B was observed in patients compared with controls (MRTF-A mRNA: twofold, p=0.028; MRTF-B mRNA: fourfold, p=0.011). miR-1 expression was associated with smoking history, lung function, fat-free mass index, 6 min walk distance and percentage of type 1 fibres. miR-133 and miR-206 were negatively correlated with daily physical activity. Insulin-like growth factor 1 mRNA was increased in the patients and miR-1 was negatively correlated with phosphorylation of the kinase Akt. Furthermore, the protein levels of histone deacetylase 4, another miR-1 target, were increased in the patients." -target gene hsa-mir-29a Gastric Neoplasms 21998710 MiR-29a Inhibits Cell Proliferation and Induces Cell Cycle Arrest through the Downregulation of p42.3 in Human Gastric Cancer. -target gene hsa-mir-21 Urinary Bladder Cancer 22001440 MiR-21 is involved in cervical squamous cell tumorigenesis and regulates CCL20. -target gene hsa-mir-137 Intellectual Disability 22003227 "The patients displayed a significantly decreased expression of both precursor and mature miR-137 levels, as well as significantly increased expression of the validated downstream targets microphthalmia-associated transcription factor (MITF) and Enhancer of Zeste, Drosophila, Homologue 2 (EZH2), and the newly identified target Kruppel-like factor 4 (KLF4). The study also demonstrated significant enrichment of miR-137 at the synapses of cortical and hippocampal neurons, suggesting a role of miR-137 in regulating local synaptic protein synthesis machinery." -target gene hsa-mir-126 Endometriosis 22012249 "The expression level of miR-126 was significantly downregulated in ECs versus EUs (p = 5.45E(-5)) in the experimental group and in EUs versus ENs (p = 0.019).miR-126 may play an initial role in the development and progression of EMs. Crk may be regulated by miR-126, and synergism between abnormal expressions may play an important role in the pathogenesis of EMs." -target gene hsa-let-7a-1 Endometrial Neoplasms 22014978 "The activated estrogen receptor can suppress the expression of BAX by upregulating a group of microRNAs including hsa-let-7 family members and hsa-miR-27a, thereby promoting an increased BCL2/BAX ratio as well as enhanced survival and proliferation in the affected cells." -target gene hsa-let-7a-2 Endometrial Neoplasms 22014978 "The activated estrogen receptor can suppress the expression of BAX by upregulating a group of microRNAs including hsa-let-7 family members and hsa-miR-27a, thereby promoting an increased BCL2/BAX ratio as well as enhanced survival and proliferation in the affected cells." -target gene hsa-let-7a-3 Endometrial Neoplasms 22014978 "The activated estrogen receptor can suppress the expression of BAX by upregulating a group of microRNAs including hsa-let-7 family members and hsa-miR-27a, thereby promoting an increased BCL2/BAX ratio as well as enhanced survival and proliferation in the affected cells." -target gene hsa-let-7b Endometrial Neoplasms 22014978 "The activated estrogen receptor can suppress the expression of BAX by upregulating a group of microRNAs including hsa-let-7 family members and hsa-miR-27a, thereby promoting an increased BCL2/BAX ratio as well as enhanced survival and proliferation in the affected cells." -target gene hsa-let-7c Endometrial Neoplasms 22014978 "The activated estrogen receptor can suppress the expression of BAX by upregulating a group of microRNAs including hsa-let-7 family members and hsa-miR-27a, thereby promoting an increased BCL2/BAX ratio as well as enhanced survival and proliferation in the affected cells." -target gene hsa-let-7d Endometrial Neoplasms 22014978 "The activated estrogen receptor can suppress the expression of BAX by upregulating a group of microRNAs including hsa-let-7 family members and hsa-miR-27a, thereby promoting an increased BCL2/BAX ratio as well as enhanced survival and proliferation in the affected cells." -target gene hsa-let-7e Endometrial Neoplasms 22014978 "The activated estrogen receptor can suppress the expression of BAX by upregulating a group of microRNAs including hsa-let-7 family members and hsa-miR-27a, thereby promoting an increased BCL2/BAX ratio as well as enhanced survival and proliferation in the affected cells." -target gene hsa-let-7f-1 Endometrial Neoplasms 22014978 "The activated estrogen receptor can suppress the expression of BAX by upregulating a group of microRNAs including hsa-let-7 family members and hsa-miR-27a, thereby promoting an increased BCL2/BAX ratio as well as enhanced survival and proliferation in the affected cells." -target gene hsa-let-7f-2 Endometrial Neoplasms 22014978 "The activated estrogen receptor can suppress the expression of BAX by upregulating a group of microRNAs including hsa-let-7 family members and hsa-miR-27a, thereby promoting an increased BCL2/BAX ratio as well as enhanced survival and proliferation in the affected cells." -target gene hsa-let-7g Endometrial Neoplasms 22014978 "The activated estrogen receptor can suppress the expression of BAX by upregulating a group of microRNAs including hsa-let-7 family members and hsa-miR-27a, thereby promoting an increased BCL2/BAX ratio as well as enhanced survival and proliferation in the affected cells." -target gene hsa-let-7i Endometrial Neoplasms 22014978 "The activated estrogen receptor can suppress the expression of BAX by upregulating a group of microRNAs including hsa-let-7 family members and hsa-miR-27a, thereby promoting an increased BCL2/BAX ratio as well as enhanced survival and proliferation in the affected cells." -target gene hsa-mir-200c Endometrial Neoplasms 22015043 "We found that miR-200c expression was increased in endometrial carcinoma compared with normal endometrial tissues. Anti-miR or pre-miR-200c could regulate cell survival, proliferation, and apoptosis and affect cytotoxicity in endometrial cancer cells. Through mRNA microarray analysis, we found that miR-200c inhibits the expression of BRD7, which was recently reported as a potential tumor suppressor gene. MiR-200c regulated the translocation of §Ø©ãcatenin from the cytoplasm to the nucleus via inhibition of BRD7, resulting in increased expression of its transcriptional target genes, cyclinD1 and c-myc." -target gene hsa-let-7a-1 Colorectal Carcinoma 22018986 NIRF is frequently upregulated in colorectal cancer and its oncogenicity can be suppressed by let-7a microRNA. -target gene hsa-let-7a-2 Colorectal Carcinoma 22018986 NIRF is frequently upregulated in colorectal cancer and its oncogenicity can be suppressed by let-7a microRNA. -target gene hsa-let-7a-3 Colorectal Carcinoma 22018986 NIRF is frequently upregulated in colorectal cancer and its oncogenicity can be suppressed by let-7a microRNA. -target gene hsa-mir-148b Colorectal Carcinoma 22020560 MicroRNA-148b suppresses cell growth by targeting cholecystokinin-2 receptor in colorectal cancer. -target gene hsa-mir-146a Gastric Neoplasms 22020746 Increased miR-146a in gastric cancer directly targets SMAD4 and is involved in modulating cell proliferation and apoptosis. -target gene hsa-mir-30c-1 Ovarian Neoplasms 22024689 MicroRNA-30c-2* expressed in ovarian cancer cells suppresses growth factor induced cellular proliferation and downregulates the oncogene BCL9. -target gene hsa-mir-30c-2 Ovarian Neoplasms 22024689 MicroRNA-30c-2* expressed in ovarian cancer cells suppresses growth factor induced cellular proliferation and downregulates the oncogene BCL9. -target gene hsa-mir-150 "Carcinoma, Hepatocellular" 22025269 microRNA-150 inhibits human CD133-positive liver cancer stem cells through negative regulation of the transcription factor c-Myb. -target gene hsa-mir-155 Lung Neoplasms 22027557 "Hypoxic conditions induce miR-155 expression in lung cancer cells and trigger a corresponding decrease in a validated target, FOXO3A. Furthermore, we find that increased levels of miR-155 radioprotects lung cancer cells, while inhibition of miR-155 radiosensitizes these cells. Moreover, we reveal a therapeutically important link between miR-155 expression, hypoxia, and irradiation by demonstrating that anti-miR-155 molecules also sensitize hypoxic lung cancer cells to irradiation. Our study helps explain how miR-155 becomes elevated in lung cancers, which contain extensive hypoxic microenvironments, and demonstrates that inhibition of miR-155 may have important therapeutic potential as a means to radiosensitize hypoxic lung cancer cells." -target gene hsa-mir-194-1 Colorectal Carcinoma 22028325 p53-responsive miR-194 inhibits thrombospondin-1 and promotes angiogenesis in colon cancers. -target gene hsa-mir-194-2 Colorectal Carcinoma 22028325 p53-responsive miR-194 inhibits thrombospondin-1 and promotes angiogenesis in colon cancers. -target gene hsa-mir-375 Head And Neck Neoplasms 22031094 "MiR-375 expression was significantly reduced (p=0.01), and conversely, MTDH was significantly increased (p=0.0001) in NPC samples. Quantitative RT-PCR, western blots and luciferase assays corroborated MTDH as a target of miR-375. Re-expression of miR-375 and siRNA knock-down of MTDH both decreased cell viability and clonogenic survival, cell migration/invasion, as well as in vivo tumour formation. NPC patients whose tumours expressed high levels of MTDH experienced significantly lower survival, and in particular, higher distant relapse rates (5-year distant relapse rates: 26% vs. 5%; p=0.005)." -target gene hsa-mir-506 Colon Neoplasms 22036718 MicroRNA 506 regulates expression of PPAR alpha in hydroxycamptothecin-resistant human colon cancer cells. -target gene hsa-mir-23a Vascular Disease [unspecific] 22038739 Our results suggest that miR-23a may be involved in TNF-¦Á-induced endothelial cell apoptosis through regulation of the caspase-7 and serine/threonine kinase?4-caspase-3 pathways. -target gene hsa-mir-150 Myocardial Infarction 22039399 microRNA-150 regulates mobilization and migration of bone marrow-derived mononuclear cells by targeting Cxcr4. -target gene hsa-mir-7-1 Glioblastoma 22040413 MicroRNA-7 regulates glioblastoma cell invasion via targeting focal adhesion kinase expression. -target gene hsa-mir-7-2 Glioblastoma 22040413 MicroRNA-7 regulates glioblastoma cell invasion via targeting focal adhesion kinase expression. -target gene hsa-mir-7-3 Glioblastoma 22040413 MicroRNA-7 regulates glioblastoma cell invasion via targeting focal adhesion kinase expression. -target gene hsa-mir-494 Gastrointestinal Neoplasms 22042971 MicroRNA-494 Downregulates KIT and Inhibits Gastrointestinal Stromal Tumor Cell Proliferation. -target gene hsa-mir-1 Heart Failure 22045061 MicroRNA-1 represses Cx43 expression in viral myocarditis. -target gene hsa-mir-125b-1 Huntington Disease 22048026 "Micro RNA -214,-150,-146a and-125b target Huntingtin gene." -target gene hsa-mir-125b-2 Huntington Disease 22048026 "Micro RNA -214,-150,-146a and-125b target Huntingtin gene." -target gene hsa-mir-146a Huntington Disease 22048026 "Micro RNA -214,-150,-146a and-125b target Huntingtin gene." -target gene hsa-mir-150 Huntington Disease 22048026 "Micro RNA -214,-150,-146a and-125b target Huntingtin gene." -target gene hsa-mir-214 Huntington Disease 22048026 "Micro RNA -214,-150,-146a and-125b target Huntingtin gene." -target gene hsa-mir-375 "Carcinoma, Hepatocellular" 22056881 MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo. -target gene hsa-mir-493 Urinary Bladder Cancer 22057916 Tumor suppressor microRNA-493 decreases cell motility and migration ability in human bladder cancer cells by down-regulating RhoC and FZD4. -target gene hsa-mir-1-1 Nasopharyngeal Neoplasms 22059741 MicroRNA-1 induces apoptosis by targeting prothymosin alpha in nasopharyngeal carcinoma cells. -target gene hsa-mir-1-2 Nasopharyngeal Neoplasms 22059741 MicroRNA-1 induces apoptosis by targeting prothymosin alpha in nasopharyngeal carcinoma cells. -target gene hsa-mir-126 Pancreatic Neoplasms 22064652 MiR-126 acts as a tumor suppressor in pancreatic cancer cells via the regulation of ADAM9. -target gene hsa-mir-1-1 Prostate Neoplasms 22068816 Tumour suppressors miR-1 and miR-133a target the oncogenic function of purine nucleoside phosphorylase (PNP) in prostate cancer. -target gene hsa-mir-1-2 Prostate Neoplasms 22068816 Tumour suppressors miR-1 and miR-133a target the oncogenic function of purine nucleoside phosphorylase (PNP) in prostate cancer. -target gene hsa-mir-133a-1 Prostate Neoplasms 22068816 Tumour suppressors miR-1 and miR-133a target the oncogenic function of purine nucleoside phosphorylase (PNP) in prostate cancer. -target gene hsa-mir-133a-2 Prostate Neoplasms 22068816 Tumour suppressors miR-1 and miR-133a target the oncogenic function of purine nucleoside phosphorylase (PNP) in prostate cancer. -target gene hsa-mir-433 Ovarian Neoplasms 22069160 "MAD2 protein expression levels were downregulated in pre-miR-433 transfected A2780 cells. Secondly, Pre-miR-433 suppressed the activity of a reporter construct containing the 3'-UTR of MAD2. Thirdly, blocking miR-433 binding to the MAD2 3'UTR protected MAD2 from miR-433 induced protein downregulation. Importantly, reduced MAD2 protein expression in pre-miR-433 transfected A2780 cells rendered these cells less sensitive to paclitaxel. In conclusion, loss of MAD2 protein expression results in increased resistance to paclitaxel in EOC cells." -target gene hsa-mir-885 "Squamous Cell Carcinoma, Head and Neck" 22071691 "miR-885-3p modulated the cisplatin-induced TP53-dependent mitochondrial apoptosis by up regulation of MDM4 levels and down regulation of BCL2 levels in mitochondria. Altogether, our results support the notion that miR-885-3p might contribute in regulation of cell viability, apoptosis and/or autophagy in squamous cell carcinoma cells upon cisplatin exposure." -target gene hsa-mir-21 Colon Neoplasms 22072622 MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFbetaR2) in colon cancer cells. -target gene hsa-mir-221 Glioma 22075712 Downregulation of miR-221/222 sensitizes glioma cells to temozolomide by regulating apoptosis independently of p53 status. -target gene hsa-mir-222 Glioma 22075712 Downregulation of miR-221/222 sensitizes glioma cells to temozolomide by regulating apoptosis independently of p53 status. -target gene hsa-mir-25 Ovarian Neoplasms 22076535 MiR-25 regulates apoptosis by targeting Bim in human ovarian cancer. -target gene hsa-mir-155 Human Immunodeficiency Virus Infection 22080513 "microRNA-223 levels were significantly enriched in HIV-1-infected CD4(+)CD8(-) PBMCs, microRNA-29a/b, microRNA-155 and microRNA-21 levels were significantly reduced. Based on the potential for microRNA binding sites in a conserved sequence of the Nef-3'-LTR, several host microRNAs potentially could affect HIV-1 gene expression. Among those microRNAs, the microRNA-29 family has seed complementarity in the HIV-1 3'-UTR, but the potential suppressive effect of microRNA-29 on HIV-1 is severely blocked by the secondary structure of the target region." -target gene hsa-mir-21 Human Immunodeficiency Virus Infection 22080513 "microRNA-223 levels were significantly enriched in HIV-1-infected CD4(+)CD8(-) PBMCs, microRNA-29a/b, microRNA-155 and microRNA-21 levels were significantly reduced. Based on the potential for microRNA binding sites in a conserved sequence of the Nef-3'-LTR, several host microRNAs potentially could affect HIV-1 gene expression. Among those microRNAs, the microRNA-29 family has seed complementarity in the HIV-1 3'-UTR, but the potential suppressive effect of microRNA-29 on HIV-1 is severely blocked by the secondary structure of the target region." -target gene hsa-mir-223 Human Immunodeficiency Virus Infection 22080513 "microRNA-223 levels were significantly enriched in HIV-1-infected CD4(+)CD8(-) PBMCs, microRNA-29a/b, microRNA-155 and microRNA-21 levels were significantly reduced. Based on the potential for microRNA binding sites in a conserved sequence of the Nef-3'-LTR, several host microRNAs potentially could affect HIV-1 gene expression. Among those microRNAs, the microRNA-29 family has seed complementarity in the HIV-1 3'-UTR, but the potential suppressive effect of microRNA-29 on HIV-1 is severely blocked by the secondary structure of the target region." -target gene hsa-mir-29a Human Immunodeficiency Virus Infection 22080513 "microRNA-223 levels were significantly enriched in HIV-1-infected CD4(+)CD8(-) PBMCs, microRNA-29a/b, microRNA-155 and microRNA-21 levels were significantly reduced. Based on the potential for microRNA binding sites in a conserved sequence of the Nef-3'-LTR, several host microRNAs potentially could affect HIV-1 gene expression. Among those microRNAs, the microRNA-29 family has seed complementarity in the HIV-1 3'-UTR, but the potential suppressive effect of microRNA-29 on HIV-1 is severely blocked by the secondary structure of the target region." -target gene hsa-mir-124-1 Breast Neoplasms 22085528 miR-124 suppresses multiple steps of breast cancer metastasis by targeting a cohort of pro-metastatic genes in vitro. -target gene hsa-mir-124-2 Breast Neoplasms 22085528 miR-124 suppresses multiple steps of breast cancer metastasis by targeting a cohort of pro-metastatic genes in vitro. -target gene hsa-mir-124-3 Breast Neoplasms 22085528 miR-124 suppresses multiple steps of breast cancer metastasis by targeting a cohort of pro-metastatic genes in vitro. -target gene hsa-mir-31 Glioma 22089331 Human miR-31 targets radixin and inhibits migration and invasion of glioma cells. -target gene hsa-mir-199a-1 "Carcinoma, Renal Cell" 22093618 Re-expression of miR-199a suppresses renal cancer cell proliferation and survival by targeting GSK-3 -target gene hsa-mir-145 Glioblastoma 22098779 "The expression of miR145 (a tumor-suppressive miRNA) is inversely correlated with the levels of Oct4 and Sox2 in GBM-CD133(+) cells and malignant glioma specimens.miR145 negatively regulates GBM tumorigenesis by targeting Oct4 and Sox2 in GBM-CD133(+). Using polyurethane-short branch polyethylenimine (PU-PEI) as a therapeutic-delivery vehicle, PU-PEI-mediated miR145 delivery to GBM-CD133(+) significantly inhibited their tumorigenic and CSC-like abilities and facilitated their differentiation into CD133(-)-non-CSCs. Furthermore, PU-PEI-miR145-treated GBM-CD133(+) effectively suppressed the expression of drug-resistance and anti-apoptotic genes and increased the sensitivity of the cells to radiation and temozolomide. Finally, the in vivo delivery of PU-PEI-miR145 alone significantly suppressed tumorigenesis with stemness, and synergistically improved the survival rate when used in combination with radiotherapy and temozolomide in orthotopic GBM-CD133(+)-transplanted immunocompromised mice. Therefore, PU-PEI-miR145 is a novel therapeutic approach for malignant brain tumors." -target gene hsa-mir-21 Colorectal Carcinoma 22099878 miR-21 functionally interacts with the 3'UTR of chemokine CCL20 and down-regulates CCL20 expression in miR-21 transfected colorectal cancer cells. -target gene hsa-mir-520e "Carcinoma, Hepatocellular" 22105365 MicroRNA-520e suppresses growth of hepatoma cells by targeting the NF-kB-inducing kinase (NIK). -target gene hsa-mir-19a Rheumatoid Arthritis 22105995 "TLR2 Expression Is Regulated by MicroRNA miR-19 in Rheumatoid Fibroblast-like Synoviocytes.Downregulation of miR-19b and miR-19a, which belongs to the same cluster, was confirmed by real-time quantitative PCR. Transfection of RA FLS with miR-19a/b mimics decreased TLR2 protein expression. In parallel, we found that both IL-6 and matrix metalloproteinase 3 secretion was significantly downregulated in activated FLS transfected with either mimic. Moreover, using a luciferase assay, we showed that miR-19a/b directly target Tlr2 mRNA." -target gene hsa-mir-19b-1 Rheumatoid Arthritis 22105995 "TLR2 Expression Is Regulated by MicroRNA miR-19 in Rheumatoid Fibroblast-like Synoviocytes.Downregulation of miR-19b and miR-19a, which belongs to the same cluster, was confirmed by real-time quantitative PCR. Transfection of RA FLS with miR-19a/b mimics decreased TLR2 protein expression. In parallel, we found that both IL-6 and matrix metalloproteinase 3 secretion was significantly downregulated in activated FLS transfected with either mimic. Moreover, using a luciferase assay, we showed that miR-19a/b directly target Tlr2 mRNA." -target gene hsa-mir-19b-2 Rheumatoid Arthritis 22105995 "TLR2 Expression Is Regulated by MicroRNA miR-19 in Rheumatoid Fibroblast-like Synoviocytes.Downregulation of miR-19b and miR-19a, which belongs to the same cluster, was confirmed by real-time quantitative PCR. Transfection of RA FLS with miR-19a/b mimics decreased TLR2 protein expression. In parallel, we found that both IL-6 and matrix metalloproteinase 3 secretion was significantly downregulated in activated FLS transfected with either mimic. Moreover, using a luciferase assay, we showed that miR-19a/b directly target Tlr2 mRNA." -target gene hsa-mir-143 Urinary Bladder Cancer 22108519 The miR-143/-145 cluster regulates plasminogen activator inhibitor-1 in bladder cancer. -target gene hsa-mir-145 Urinary Bladder Cancer 22108519 The miR-143/-145 cluster regulates plasminogen activator inhibitor-1 in bladder cancer. -target gene hsa-mir-206 Laryngeal Neoplasms 22110210 Down-regulation of MiR-206 Promotes Proliferation and Invasion of Laryngeal Cancer by Regulating VEGF Expression. -target gene hsa-mir-34b Breast Neoplasms 22113133 "In this study, we identified one such estrogen down-regulated microRNA, miR-34b, as an onco-suppressor that targets cyclin D1 and JAG-1 (jagged 1) in a ER-positive/wild-type p53 breast cancer cell line (MCF-7) as well as in ovarian and endometrial cells," -target gene hsa-mir-17 "Lymphoma, Mantle-Cell" 22116552 The miRNA-17-92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation. -target gene hsa-mir-18a "Lymphoma, Mantle-Cell" 22116552 The miRNA-17-92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation. -target gene hsa-mir-19a "Lymphoma, Mantle-Cell" 22116552 The miRNA-17-92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation. -target gene hsa-mir-19b-1 "Lymphoma, Mantle-Cell" 22116552 The miRNA-17-92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation. -target gene hsa-mir-20a "Lymphoma, Mantle-Cell" 22116552 The miRNA-17-92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation. -target gene hsa-mir-92a-1 "Lymphoma, Mantle-Cell" 22116552 The miRNA-17-92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation. -target gene hsa-mir-378a Cardiovascular Diseases [unspecific] 22119805 Overexpression of microRNA-378 attenuates ischemia-induced apoptosis by inhibiting caspase-3 expression in cardiac myocytes. -target gene hsa-mir-100 Lung Neoplasms 22120675 MiR-100 Resensitizes Docetaxel-Resistant Human Lung Adenocarcinoma Cells (SPC-A1) to Docetaxel by Targeting Plk1. -target gene hsa-mir-27b Neuroblastoma 22120719 "MiR-27b targets PPARgamma to inhibit growth, tumor progression and the inflammatory response in neuroblastoma cells." -target gene hsa-mir-1915 Colorectal Carcinoma 22121083 miR-1915 inhibits Bcl-2 to modulate multidrug resistance by increasing drug-sensitivity in human colorectal carcinoma cells. -target gene hsa-mir-221 Colon Neoplasms 22126772 MicroRNA-221 promotes colon carcinoma cell proliferation in vitro by inhibiting CDKN1C/p57 expression. -target gene hsa-let-7c Prostate Neoplasms 22128178 MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells. -target gene hsa-mir-21 Melanoma 22130252 "Increased levels of microRNA-21 expression were shown from dysplastic nevi to primary cutaneous melanomas to melanoma metastases. Moreover, high miR-21 expression was found to be correlated with Breslow thickness and advanced clinical stage. Patients with high microRNA-21 expression showed shorter 5-year disease-free or overall survival than those with low microRNA-21 expression. Furthermore, multivariate regression analysis showed that the status of microRNA-21 expression was an independent prognostic factor for overall survival of patients. Antisense-mediated microRNA-21 inhibition could significantly suppress growth, increase apoptosis and enhance chemo- or radiosensitivity of human cutaneous melanoma cells by inducing the increased Bax/Bcl-2 ratio. Thus, the status of microRNA-21 might be an independent prognostic factor for patients with cutaneous melanoma, and microRNA-21 has the potential of being a novel molecular target for the treatment of human cutaneous melanoma." -target gene hsa-mir-17 Colorectal Carcinoma 22132820 "Up-regulated miR-17 promotes cell proliferation, tumor growth and cell cycle progression by targeting RND3 tumor suppressor gene in colorectal carcinoma." -target gene hsa-mir-330 Colon Neoplasms 22132977 "Expression of miR-330 in various colon and lung cancer cell lines, as measured by QRT-PCR, varied five-fold between samples and correlated with in-vitro gemcitabine resistance (R = 0.82, p = 0.04). Exposure to gemcitabine also appeared to influence miR-330 levels in these cell lines. Furthermore, in our cell line panel, miR-330 expression negatively correlated with dCK mRNA expression (R = 0.74), suggesting a role of miR-330 in post-transcriptional regulation of dCK." -target gene hsa-mir-330 Lung Neoplasms 22132977 "Expression of miR-330 in various colon and lung cancer cell lines, as measured by QRT-PCR, varied five-fold between samples and correlated with in-vitro gemcitabine resistance (R = 0.82, p = 0.04). Exposure to gemcitabine also appeared to influence miR-330 levels in these cell lines. Furthermore, in our cell line panel, miR-330 expression negatively correlated with dCK mRNA expression (R = 0.74), suggesting a role of miR-330 in post-transcriptional regulation of dCK." -target gene hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 22133358 miR-15a and miR-16-1 inhibit the proliferation of leukemic cells by down-regulating WT1 protein level. -target gene hsa-mir-15a "Leukemia, Myeloid, Acute" 22133358 miR-15a and miR-16-1 inhibit the proliferation of leukemic cells by down-regulating WT1 protein level. -target gene hsa-mir-15a Multiple Myeloma 22133358 miR-15a and miR-16-1 inhibit the proliferation of leukemic cells by down-regulating WT1 protein level. -target gene hsa-mir-320a Colorectal Carcinoma 22134529 microRNA-320a inhibits tumor invasion by targeting neuropilin 1 and is associated with liver metastasis in colorectal cancer. -target gene hsa-mir-24-1 Laryngeal Neoplasms 22139384 miR-24 functions as a tumor suppressor in Hep2 laryngeal carcinoma cells partly through down-regulation of the S100A8 protein. -target gene hsa-mir-24-2 Laryngeal Neoplasms 22139384 miR-24 functions as a tumor suppressor in Hep2 laryngeal carcinoma cells partly through down-regulation of the S100A8 protein. -target gene hsa-mir-200b Lung Neoplasms 22139708 MicroRNA-200b reverses chemoresistance of docetaxel-resistant human lung adenocarcinoma cells by targeting E2F3. -target gene hsa-mir-125b-1 "Leukemia, B-Cell" 22139839 MiR-125b and miR-155 contribute to BCL2 repression and proliferation in response to CD40 ligand (CD154) in human leukemic B-cells. -target gene hsa-mir-125b-2 "Leukemia, B-Cell" 22139839 MiR-125b and miR-155 contribute to BCL2 repression and proliferation in response to CD40 ligand (CD154) in human leukemic B-cells. -target gene hsa-mir-155 "Leukemia, B-Cell" 22139839 MiR-125b and miR-155 contribute to BCL2 repression and proliferation in response to CD40 ligand (CD154) in human leukemic B-cells. -target gene hsa-mir-210 "Carcinoma, Hepatocellular" 22144109 Hypoxia-inducible MicroRNA-210 augments the metastatic potential of tumor cells by targeting vacuole membrane protein 1 in hepatocellular carcinoma. -target gene hsa-mir-200c Breast Neoplasms 22144583 MicroRNA-200c represses migration and invasion of breast cancer cells by targeting actin-regulatory proteins FHOD1 and PPM1F. -target gene hsa-mir-421 Biliary Tract Neoplasms 22146319 MicroRNA-421 functions as an oncogenic miRNA in biliary tract cancer through down-regulating farnesoid X receptor expression. -target gene hsa-mir-23b Pain 22149086 MiR23b Ameliorates Neuropathic Pain in Spinal Cord by Silencing NOX4. -target gene hsa-mir-221 "Carcinoma, Hepatocellular" 22152314 MiR-221 contributes to the growth of hepatocellular carcinoma cells and miR-221 inhibition can induce cell apoptosis. miR-221 has the potential to become one of the new molecular targets for liver cancer therapy. -target gene hsa-let-7a "Carcinoma, Renal Cell" 22155254 Our results suggest for the first time that let-7a acts as a tumor suppressor in RCC cell lines by down-regulating c-myc and c-myc target genes. -target gene hsa-mir-103a-1 Lung Neoplasms 22157681 "Here we report that miR-30b, miR-30c, miR-221 and miR-222 are modulated by both epidermal growth factor (EGF) and MET receptors, whereas miR-103 and miR-203 are controlled only by MET. We showed that these miRNAs have important roles in gefitinib-induced apoptosis and epithelial-mesenchymal transition of NSCLC cells in vitro and in vivo by inhibiting the expression of the genes encoding BCL2-like 11 (BIM), apoptotic peptidase activating factor 1 (APAF-1), protein kinase C ? (PKC-?) and sarcoma viral oncogene homolog (SRC)." -target gene hsa-mir-103a-2 Lung Neoplasms 22157681 "Here we report that miR-30b, miR-30c, miR-221 and miR-222 are modulated by both epidermal growth factor (EGF) and MET receptors, whereas miR-103 and miR-203 are controlled only by MET. We showed that these miRNAs have important roles in gefitinib-induced apoptosis and epithelial-mesenchymal transition of NSCLC cells in vitro and in vivo by inhibiting the expression of the genes encoding BCL2-like 11 (BIM), apoptotic peptidase activating factor 1 (APAF-1), protein kinase C ? (PKC-?) and sarcoma viral oncogene homolog (SRC)." -target gene hsa-mir-103b-1 Lung Neoplasms 22157681 "Here we report that miR-30b, miR-30c, miR-221 and miR-222 are modulated by both epidermal growth factor (EGF) and MET receptors, whereas miR-103 and miR-203 are controlled only by MET. We showed that these miRNAs have important roles in gefitinib-induced apoptosis and epithelial-mesenchymal transition of NSCLC cells in vitro and in vivo by inhibiting the expression of the genes encoding BCL2-like 11 (BIM), apoptotic peptidase activating factor 1 (APAF-1), protein kinase C ? (PKC-?) and sarcoma viral oncogene homolog (SRC)." -target gene hsa-mir-103b-2 Lung Neoplasms 22157681 "Here we report that miR-30b, miR-30c, miR-221 and miR-222 are modulated by both epidermal growth factor (EGF) and MET receptors, whereas miR-103 and miR-203 are controlled only by MET. We showed that these miRNAs have important roles in gefitinib-induced apoptosis and epithelial-mesenchymal transition of NSCLC cells in vitro and in vivo by inhibiting the expression of the genes encoding BCL2-like 11 (BIM), apoptotic peptidase activating factor 1 (APAF-1), protein kinase C ? (PKC-?) and sarcoma viral oncogene homolog (SRC)." -target gene hsa-mir-203 Lung Neoplasms 22157681 "Here we report that miR-30b, miR-30c, miR-221 and miR-222 are modulated by both epidermal growth factor (EGF) and MET receptors, whereas miR-103 and miR-203 are controlled only by MET. We showed that these miRNAs have important roles in gefitinib-induced apoptosis and epithelial-mesenchymal transition of NSCLC cells in vitro and in vivo by inhibiting the expression of the genes encoding BCL2-like 11 (BIM), apoptotic peptidase activating factor 1 (APAF-1), protein kinase C ? (PKC-?) and sarcoma viral oncogene homolog (SRC)." -target gene hsa-mir-221 Lung Neoplasms 22157681 "Here we report that miR-30b, miR-30c, miR-221 and miR-222 are modulated by both epidermal growth factor (EGF) and MET receptors, whereas miR-103 and miR-203 are controlled only by MET. We showed that these miRNAs have important roles in gefitinib-induced apoptosis and epithelial-mesenchymal transition of NSCLC cells in vitro and in vivo by inhibiting the expression of the genes encoding BCL2-like 11 (BIM), apoptotic peptidase activating factor 1 (APAF-1), protein kinase C ? (PKC-?) and sarcoma viral oncogene homolog (SRC)." -target gene hsa-mir-222 Lung Neoplasms 22157681 "Here we report that miR-30b, miR-30c, miR-221 and miR-222 are modulated by both epidermal growth factor (EGF) and MET receptors, whereas miR-103 and miR-203 are controlled only by MET. We showed that these miRNAs have important roles in gefitinib-induced apoptosis and epithelial-mesenchymal transition of NSCLC cells in vitro and in vivo by inhibiting the expression of the genes encoding BCL2-like 11 (BIM), apoptotic peptidase activating factor 1 (APAF-1), protein kinase C ? (PKC-?) and sarcoma viral oncogene homolog (SRC)." -target gene hsa-mir-30b Lung Neoplasms 22157681 "Here we report that miR-30b, miR-30c, miR-221 and miR-222 are modulated by both epidermal growth factor (EGF) and MET receptors, whereas miR-103 and miR-203 are controlled only by MET. We showed that these miRNAs have important roles in gefitinib-induced apoptosis and epithelial-mesenchymal transition of NSCLC cells in vitro and in vivo by inhibiting the expression of the genes encoding BCL2-like 11 (BIM), apoptotic peptidase activating factor 1 (APAF-1), protein kinase C ? (PKC-?) and sarcoma viral oncogene homolog (SRC)." -target gene hsa-mir-30c-1 Lung Neoplasms 22157681 "Here we report that miR-30b, miR-30c, miR-221 and miR-222 are modulated by both epidermal growth factor (EGF) and MET receptors, whereas miR-103 and miR-203 are controlled only by MET. We showed that these miRNAs have important roles in gefitinib-induced apoptosis and epithelial-mesenchymal transition of NSCLC cells in vitro and in vivo by inhibiting the expression of the genes encoding BCL2-like 11 (BIM), apoptotic peptidase activating factor 1 (APAF-1), protein kinase C ? (PKC-?) and sarcoma viral oncogene homolog (SRC)." -target gene hsa-mir-30c-2 Lung Neoplasms 22157681 "Here we report that miR-30b, miR-30c, miR-221 and miR-222 are modulated by both epidermal growth factor (EGF) and MET receptors, whereas miR-103 and miR-203 are controlled only by MET. We showed that these miRNAs have important roles in gefitinib-induced apoptosis and epithelial-mesenchymal transition of NSCLC cells in vitro and in vivo by inhibiting the expression of the genes encoding BCL2-like 11 (BIM), apoptotic peptidase activating factor 1 (APAF-1), protein kinase C ? (PKC-?) and sarcoma viral oncogene homolog (SRC)." -target gene hsa-mir-30a Breast Neoplasms 22157765 MicroRNA-30a sensitizes tumor cells to cis-platinum via suppressing beclin 1-mediated autophagy. -target gene hsa-mir-30a "Carcinoma, Hepatocellular" 22157765 MicroRNA-30a sensitizes tumor cells to cis-platinum via suppressing beclin 1-mediated autophagy. -target gene hsa-mir-30a Ovarian Neoplasms 22157765 MicroRNA-30a sensitizes tumor cells to cis-platinum via suppressing beclin 1-mediated autophagy. -target gene hsa-mir-373 Breast Neoplasms 22158050 MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-kB and TGF-beta signaling pathways. -target gene hsa-mir-520a Breast Neoplasms 22158050 MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-kB and TGF-beta signaling pathways. -target gene hsa-mir-520b Breast Neoplasms 22158050 MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-kB and TGF-beta signaling pathways. -target gene hsa-mir-520c Breast Neoplasms 22158050 MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-kB and TGF-beta signaling pathways. -target gene hsa-mir-520d Breast Neoplasms 22158050 MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-kB and TGF-beta signaling pathways. -target gene hsa-mir-1245a Breast Neoplasms 22158906 Upregulation of miR-1245 by c-myc targets BRCA2 and impairs DNA repair. -target gene hsa-mir-1245b Breast Neoplasms 22158906 Upregulation of miR-1245 by c-myc targets BRCA2 and impairs DNA repair. -target gene hsa-mir-34a "Carcinoma, Renal Cell" 22159222 MicroRNA-34a suppresses malignant transformation by targeting c-Myc transcriptional complexes in human renal cell carcinoma. -target gene hsa-mir-205 Glioblastoma 22159356 MicroRNA-205 functions as a tumor suppressor in human glioblastoma cells by targeting VEGF-A. -target gene hsa-mir-143 Urinary Bladder Cancer 22160209 miR-143 is downregulated in cervical cancer and promotes apoptosis and inhibits tumor formation by targeting Bcl-2. -target gene hsa-mir-34a Neuroblastoma 22160687 "Notably, the axis TAp73/miR-34a/synaptotagmin-1 is conserved in brains from Alzheimer's patients. " -target gene hsa-mir-146a Prostate Neoplasms 22161865 MiR-146a suppresses tumor growth and progression by targeting EGFR pathway and in a p-ERK-dependent manner in castration-resistant prostate cancer. -target gene hsa-mir-146a "Carcinoma, Hepatocellular" 22167321 "The authors demonstrate that miR-146a, miR-99b and miR-205, induced in HCC1937 BRCA1-expressing cells, bind and regulate TRAF2 gene. In addition, re-expression of miR-146a, miR-99b or miR-205 in HCC1937 BRCA1-null cells was sufficient to modulate NF-§Ø¨mB activity." -target gene hsa-mir-205 "Carcinoma, Hepatocellular" 22167321 "The authors demonstrate that miR-146a, miR-99b and miR-205, induced in HCC1937 BRCA1-expressing cells, bind and regulate TRAF2 gene. In addition, re-expression of miR-146a, miR-99b or miR-205 in HCC1937 BRCA1-null cells was sufficient to modulate NF-§Ø¨mB activity." -target gene hsa-mir-99b "Carcinoma, Hepatocellular" 22167321 "The authors demonstrate that miR-146a, miR-99b and miR-205, induced in HCC1937 BRCA1-expressing cells, bind and regulate TRAF2 gene. In addition, re-expression of miR-146a, miR-99b or miR-205 in HCC1937 BRCA1-null cells was sufficient to modulate NF-§Ø¨mB activity." -target gene hsa-mir-21 Ovarian Neoplasms 22176994 miR-21 might play an important role in the proliferation and apoptosis of ovarian epithelial carcinoma cells through negatively control the expression of PDCD4. -target gene hsa-mir-1-1 Urinary Bladder Cancer 22178073 Tumor suppressive microRNA-1 mediated novel apoptosis pathways through direct inhibition of splicing factor serine/arginine-rich 9 (SRSF9/SRp30c) in bladder cancer. -target gene hsa-mir-1-2 Urinary Bladder Cancer 22178073 Tumor suppressive microRNA-1 mediated novel apoptosis pathways through direct inhibition of splicing factor serine/arginine-rich 9 (SRSF9/SRp30c) in bladder cancer. -target gene hsa-mir-124-1 Alzheimer Disease 22178568 The miR-124 regulates the expression of BACE1/-secretase correlated with cell death in Alzheimer's disease. -target gene hsa-mir-124-2 Alzheimer Disease 22178568 The miR-124 regulates the expression of BACE1/-secretase correlated with cell death in Alzheimer's disease. -target gene hsa-mir-124-3 Alzheimer Disease 22178568 The miR-124 regulates the expression of BACE1/-secretase correlated with cell death in Alzheimer's disease. -target gene hsa-mir-320a Breast Neoplasms 22179046 Expression of the Pten-miR-320-Ets2-regulated secretome distinguished human normal breast stroma from tumour stroma and robustly correlated with recurrence in breast cancer patients. This work reveals miR-320 as a critical component of the Pten tumour-suppressor axis that acts in stromal fibroblasts to reprogramme the tumour microenvironment and curtail tumour progression. -target gene hsa-mir-320b-1 Breast Neoplasms 22179046 Expression of the Pten-miR-320-Ets2-regulated secretome distinguished human normal breast stroma from tumour stroma and robustly correlated with recurrence in breast cancer patients. This work reveals miR-320 as a critical component of the Pten tumour-suppressor axis that acts in stromal fibroblasts to reprogramme the tumour microenvironment and curtail tumour progression. -target gene hsa-mir-320b-2 Breast Neoplasms 22179046 Expression of the Pten-miR-320-Ets2-regulated secretome distinguished human normal breast stroma from tumour stroma and robustly correlated with recurrence in breast cancer patients. This work reveals miR-320 as a critical component of the Pten tumour-suppressor axis that acts in stromal fibroblasts to reprogramme the tumour microenvironment and curtail tumour progression. -target gene hsa-mir-320c-1 Breast Neoplasms 22179046 Expression of the Pten-miR-320-Ets2-regulated secretome distinguished human normal breast stroma from tumour stroma and robustly correlated with recurrence in breast cancer patients. This work reveals miR-320 as a critical component of the Pten tumour-suppressor axis that acts in stromal fibroblasts to reprogramme the tumour microenvironment and curtail tumour progression. -target gene hsa-mir-320c-2 Breast Neoplasms 22179046 Expression of the Pten-miR-320-Ets2-regulated secretome distinguished human normal breast stroma from tumour stroma and robustly correlated with recurrence in breast cancer patients. This work reveals miR-320 as a critical component of the Pten tumour-suppressor axis that acts in stromal fibroblasts to reprogramme the tumour microenvironment and curtail tumour progression. -target gene hsa-mir-320d-1 Breast Neoplasms 22179046 Expression of the Pten-miR-320-Ets2-regulated secretome distinguished human normal breast stroma from tumour stroma and robustly correlated with recurrence in breast cancer patients. This work reveals miR-320 as a critical component of the Pten tumour-suppressor axis that acts in stromal fibroblasts to reprogramme the tumour microenvironment and curtail tumour progression. -target gene hsa-mir-320d-2 Breast Neoplasms 22179046 Expression of the Pten-miR-320-Ets2-regulated secretome distinguished human normal breast stroma from tumour stroma and robustly correlated with recurrence in breast cancer patients. This work reveals miR-320 as a critical component of the Pten tumour-suppressor axis that acts in stromal fibroblasts to reprogramme the tumour microenvironment and curtail tumour progression. -target gene hsa-mir-320e Breast Neoplasms 22179046 Expression of the Pten-miR-320-Ets2-regulated secretome distinguished human normal breast stroma from tumour stroma and robustly correlated with recurrence in breast cancer patients. This work reveals miR-320 as a critical component of the Pten tumour-suppressor axis that acts in stromal fibroblasts to reprogramme the tumour microenvironment and curtail tumour progression. -target gene hsa-mir-451a Glioma 22179124 MicroRNA miR-451 downregulates the PI3K/AKT pathway through CAB39 in human glioma. -target gene hsa-mir-409 Gastric Neoplasms 22179828 MicroRNA-409 suppresses tumour cell invasion and metastasis by directly targeting radixin in gastric cancers. -target gene hsa-mir-137 Schizophrenia 22182936 "Schizophrenia-associated genes CSMD1, C10orf26, CACNA1C and TCF4 are miR-137 targets." -target gene hsa-mir-200a Lymphoma 22183793 "MicroRNA-200 is commonly repressed in conjunctival MALT lymphoma, and targets cyclin E2." -target gene hsa-mir-200b Lymphoma 22183793 "MicroRNA-200 is commonly repressed in conjunctival MALT lymphoma, and targets cyclin E2." -target gene hsa-mir-200c Lymphoma 22183793 "MicroRNA-200 is commonly repressed in conjunctival MALT lymphoma, and targets cyclin E2." -target gene hsa-mir-365a Lung Neoplasms 22185756 MiR-365 regulates lung cancer and developmental gene thyroid transcription factor 1. -target gene hsa-mir-365b Lung Neoplasms 22185756 MiR-365 regulates lung cancer and developmental gene thyroid transcription factor 1. -target gene hsa-mir-20a Osteosarcoma 22186140 miR-20a increases the metastatic potential of osteosarcoma cells by regulating Fas expression. -target gene hsa-mir-34a Colon Neoplasms 22198213 MicroRNA-34a inhibits migration and invasion of colon cancer cells via targeting to Fra-1. -target gene hsa-mir-210 Preeclampsia 22203747 Hydroxysteroid (17-beta) Dehydrogenase 1 Is Dysregulated by Mir-210 and Mir-518c That Are Aberrantly Expressed in Preeclamptic Placentas. -target gene hsa-mir-518c Preeclampsia 22203747 Hydroxysteroid (17-beta) Dehydrogenase 1 Is Dysregulated by Mir-210 and Mir-518c That Are Aberrantly Expressed in Preeclamptic Placentas. -target gene hsa-mir-181d Glioma 22207524 MiR-181d acts as a tumor suppressor in glioma by targeting K-ras and Bcl-2. -target gene hsa-mir-203 Breast Neoplasms 22207897 Anti-miR-203 Upregulates SOCS3 Expression in Breast Cancer Cells and Enhances Cisplatin Chemosensitivity. -target gene hsa-mir-195 Glioblastoma 22217655 MicroRNA-195 plays a tumor-suppressor role in human glioblastoma cells by targeting signaling pathways involved in cellular proliferation and invasion. -target gene hsa-mir-1236 Inflammation 22223733 Mirtron MicroRNA-1236 Inhibits VEGFR-3 Signaling During Inflammatory Lymphangiogenesis. -target gene hsa-mir-17 Schizophrenia 22228753 Expression of NPAS3 in the Human Cortex is regulated by miR-17 During Development and has Implications for Schizophrenia. -target gene hsa-mir-7-1 "Carcinoma, Hepatocellular" 22234835 miR-7 inhibits tumor growth and metastasis by targeting the PI3K/AKT pathway in hepatocellular carcinoma. -target gene hsa-mir-7-2 "Carcinoma, Hepatocellular" 22234835 miR-7 inhibits tumor growth and metastasis by targeting the PI3K/AKT pathway in hepatocellular carcinoma. -target gene hsa-mir-7-3 "Carcinoma, Hepatocellular" 22234835 miR-7 inhibits tumor growth and metastasis by targeting the PI3K/AKT pathway in hepatocellular carcinoma. -target gene hsa-mir-122 Lymphoma 22235305 miR-122 regulates p53/Akt signalling and the chemotherapy-induced apoptosis in cutaneous T-cell lymphoma. -target gene hsa-mir-211 Colorectal Carcinoma 22235338 MicroRNA-211 expression promotes colorectal cancer cell growth in vitro and in vivo by targeting tumor suppressor CHD5. -target gene hsa-mir-212 "Leukemia, Myeloid, Chronic" 22241070 ABCG2 protein was 7.2-fold elevated after long-term treatment with imatinib and decreased gradually at higher concentrations. miRNAs miR-212 and miR-328 were identified to correlate inversely with ABCG2 expression under these conditions. -target gene hsa-mir-328 "Leukemia, Myeloid, Chronic" 22241070 ABCG2 protein was 7.2-fold elevated after long-term treatment with imatinib and decreased gradually at higher concentrations. miRNAs miR-212 and miR-328 were identified to correlate inversely with ABCG2 expression under these conditions. -target gene hsa-mir-34a Laryngeal Neoplasms 22246523 MicroRNA-34a affects the occurrence of laryngeal squamous cell carcinoma by targeting the antiapoptotic gene survivin. -target gene hsa-mir-663a Nasopharyngeal Neoplasms 22249270 "MiR-663, a microRNA targeting p21(WAF1/CIP1), promotes the proliferation and tumorigenesis of nasopharyngeal carcinoma." -target gene hsa-mir-124-1 Medulloblastoma 22249617 hsa-mir-124a targeted 3'UTR of HMGA1 and negatively modulated the expression in MB cells. -target gene hsa-let-7a-1 Breast Neoplasms 22251626 MicroRNA let-7a suppresses breast cancer cell migration and invasion through downregulation of C-C chemokine receptor type 7. -target gene hsa-let-7a-2 Breast Neoplasms 22251626 MicroRNA let-7a suppresses breast cancer cell migration and invasion through downregulation of C-C chemokine receptor type 7. -target gene hsa-let-7a-3 Breast Neoplasms 22251626 MicroRNA let-7a suppresses breast cancer cell migration and invasion through downregulation of C-C chemokine receptor type 7. -target gene hsa-let-7i Pancreatic Neoplasms 22261338 "The miRNAs, let-7i and miR-143 was found to target Ras, and forced re-expression of let-7i and miR-143 inhibited Ras activity, cell proliferation and colony formation in vitro." -target gene hsa-mir-143 Pancreatic Neoplasms 22261338 "The miRNAs, let-7i and miR-143 was found to target Ras, and forced re-expression of let-7i and miR-143 inhibited Ras activity, cell proliferation and colony formation in vitro." -target gene hsa-mir-31 Leukemia 22264793 Polycomb-mediated loss of miR-31 activates NIK-dependent NF-kB pathway in adult T cell leukemia and other cancers. -target gene hsa-mir-195 Urinary Bladder Cancer 22265971 MicroRNA-195-5p suppresses glucose uptake and proliferation of human bladder cancer T24 cells by regulating GLUT3 expression. -target gene hsa-mir-449a Urinary Bladder Cancer 22266187 MicroRNA-449a acts as a tumor suppressor in human bladder cancer through the regulation of pocket proteins. -target gene hsa-mir-133a-1 Head And Neck Neoplasms 22266319 Tumor suppressive microRNA-133a regulates novel targets: Moesin contributes to cancer cell proliferation and invasion in head and neck squamous cell carcinoma. -target gene hsa-mir-32 Prostate Neoplasms 22266859 Androgen-regulated miR-32 targets BTG2 and is overexpressed in castration-resistant prostate cancer. -target gene hsa-mir-21 Gastric Neoplasms 22267008 microRNA-21 promotes tumor proliferation and invasion in gastric cancer by targeting PTEN. -target gene hsa-mir-21 Colorectal Carcinoma 22267128 Significant inverse correlations were demonstrated between PDCD4 and miR-21. -target gene hsa-mir-223 Gastric Neoplasms 22270966 MicroRNA-223 functions as an oncogene in human gastric cancer by targeting FBXW7/hCdc4. -target gene hsa-mir-221 Hypertrophy 22275134 MiR-221 promotes cardiac hypertrophy in vitro through the modulation of p27 expression. -target gene hsa-mir-122 "Carcinoma, Hepatocellular" 22276989 MicroRNA-122 suppresses cell proliferation and induces cell apoptosis in hepatocellular carcinoma by directly targeting Wnt/§Ø©ãcatenin pathway. -target gene hsa-mir-181a-2 Leukemia 22285729 miR-181a sensitizes a multidrug-resistant leukemia cell line K562/A02 to daunorubicin by targeting BCL-2. -target gene hsa-mir-21 Leprosy 22286305 MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy -target gene hsa-mir-106b Breast Neoplasms 22286770 "The miR-106b-25 cluster targets Smad7, activates TGF-beta signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer." -target gene hsa-mir-25 Breast Neoplasms 22286770 "The miR-106b-25 cluster targets Smad7, activates TGF-beta signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer." -target gene hsa-mir-30a Colon Neoplasms 22287560 MiR-30a-5p suppresses tumor growth in colon carcinoma by targeting DTL. -target gene hsa-mir-127 Inflammation 22287715 MicroRNA-127 Inhibits Lung Inflammation by Targeting IgG Fcgamma Receptor I. -target gene hsa-mir-195 Urinary Bladder Cancer 22289176 Cyclin-dependent kinase 4 is a novel target in micoRNA-195-mediated cell cycle arrest in bladder cancer cells. -target gene hsa-mir-29b-1 "Carcinoma, Lung, Non-Small-Cell" 22290228 miR-29b is an upstream molecule of PTEN. miR-29b regulates PTEN gene expression through downregulating Dnmts expression and subsequently induces hypomethylation in PTEN promoter. -target gene hsa-mir-29b-2 "Carcinoma, Lung, Non-Small-Cell" 22290228 miR-29b is an upstream molecule of PTEN. miR-29b regulates PTEN gene expression through downregulating Dnmts expression and subsequently induces hypomethylation in PTEN promoter. -target gene hsa-mir-125b-1 "Carcinoma, Hepatocellular" 22293115 MicroRNA-125b induces cancer cell apoptosis through suppression of Bcl-2 expression. -target gene hsa-mir-125b-2 "Carcinoma, Hepatocellular" 22293115 MicroRNA-125b induces cancer cell apoptosis through suppression of Bcl-2 expression. -target gene hsa-mir-10b Gastric Neoplasms 22293682 miR-10b promotes cell invasion through RhoC-AKT signaling pathway by targeting HOXD10 in gastric cancer. -target gene hsa-mir-221 Glioblastoma 22294051 miR-221/222 is the regulator of Cx43 expression in human glioblastoma cells. -target gene hsa-mir-1285-1 "Carcinoma, Renal Cell" 22294552 Tumor suppressive microRNA-1285 regulates novel molecular targets: Aberrant expression and functional significance in renal cell carcinoma. -target gene hsa-mir-1285-2 "Carcinoma, Renal Cell" 22294552 Tumor suppressive microRNA-1285 regulates novel molecular targets: Aberrant expression and functional significance in renal cell carcinoma. -target gene hsa-mir-125b-1 Alzheimer Disease 22302353 miR-125b and miR-146a regulate Complement Factor H (CFH) in Alzheimer's Disease (AD) Brain. -target gene hsa-mir-125b-2 Alzheimer Disease 22302353 miR-125b and miR-146a regulate Complement Factor H (CFH) in Alzheimer's Disease (AD) Brain. -target gene hsa-mir-146a Alzheimer Disease 22302353 miR-125b and miR-146a regulate Complement Factor H (CFH) in Alzheimer's Disease (AD) Brain. -target gene hsa-mir-203 Laryngeal Neoplasms 22306317 MicroRNA-203 leads to G1 phase cell cycle arrest in laryngeal carcinoma cells by directly targeting survivin. -target gene hsa-mir-205 Nasopharyngeal Neoplasms 22306986 MiR-205 determines the radioresistance of human nasopharyngeal carcinoma by directly targeting PTEN. -target gene hsa-mir-125b-1 Breast Neoplasms 22307404 miR-125b targets ARID3B in breast cancer cells. -target gene hsa-mir-125b-2 Breast Neoplasms 22307404 miR-125b targets ARID3B in breast cancer cells. -target gene hsa-mir-155 "Carcinoma, Renal Cell" 22307849 microRNA-155 silencing inhibits proliferation and migration and induces apoptosis by upregulating BACH1 in renal cancer cells. -target gene hsa-mir-9-1 "Lymphoma, Hodgkin" 22310293 Inhibition of miR-9 de-represses HuR and DICER1 and impairs Hodgkin lymphoma tumour outgrowth in vivo. -target gene hsa-mir-9-2 "Lymphoma, Hodgkin" 22310293 Inhibition of miR-9 de-represses HuR and DICER1 and impairs Hodgkin lymphoma tumour outgrowth in vivo. -target gene hsa-mir-9-3 "Lymphoma, Hodgkin" 22310293 Inhibition of miR-9 de-represses HuR and DICER1 and impairs Hodgkin lymphoma tumour outgrowth in vivo. -target gene hsa-mir-135a-1 Gastric Neoplasms 22310976 MiR-135a targets JAK2 and inhibits gastric cancer cell proliferation. -target gene hsa-mir-135a-2 Gastric Neoplasms 22310976 MiR-135a targets JAK2 and inhibits gastric cancer cell proliferation. -target gene hsa-mir-499a "Carcinoma, Hepatocellular" 22311030 "hsa-mir-499 (rs3746444; adenine to guanine [C-T]) .Significant differences were found in frequency and distribution of the genotypes of miRNA-499 between the HCC and the control group. Compared with miRNA-499 T/T, the odds ratio (OR) of patients with miRNA-499 C/C for developing HCC was 3.630 (95% CI: 1.545-8.532), and OR for developing HBV-related HCC was 3.133 (95% CI: 1.248-7.861)." -target gene hsa-mir-200b Gastric Neoplasms 22311119 "MicroRNA-200b Regulates Cell Proliferation, Invasion, and Migration by Directly Targeting ZEB2 in Gastric Carcinoma." -target gene hsa-mir-141 Prostate Neoplasms 22314666 miR-141 modulates androgen receptor transcriptional activity in human prostate cancer cells through targeting the small heterodimer partner protein. -target gene hsa-mir-23a "Carcinoma, Hepatocellular" 22318941 Stat3-mediated activation of miR-23a suppresses gluconeogenesis in hepatocellular carcinoma by downregulating G6PC and PGC-1§Ø©ã -target gene hsa-mir-520b "Carcinoma, Hepatocellular" 22319632 MicroRNA-520b inhibits growth of hepatoma cells by targeting MEKK2 and cyclin D1. -target gene hsa-mir-30c-1 "Carcinoma, Hepatocellular" 22320217 miR-30c-1* promotes natural killer cell cytotoxicity against human hepatoma cells by targeting the transcription factor HMBOX1. -target gene hsa-mir-30c-2 "Carcinoma, Hepatocellular" 22320217 miR-30c-1* promotes natural killer cell cytotoxicity against human hepatoma cells by targeting the transcription factor HMBOX1. -target gene hsa-mir-222 Gastric Neoplasms 22321642 Increased miR-222 in H. pylori-associated gastric cancer correlated with tumor progression by promoting cancer cell proliferation and targeting RECK. -target gene hsa-mir-21 "Carcinoma, Hepatocellular" 22322403 miR-21 promotes migration and invasion by the miR-21-PDCD4-AP-1 feedback loop in human hepatocellular carcinoma. -target gene hsa-mir-21 Colon Neoplasms 22322462 microRNA-21-mediated regulation of Sprouty2 protein expression enhances the cytotoxic effect of 5-fluorouracil and metformin in colon cancer cells. -target gene hsa-mir-182 Gastric Neoplasms 22325466 MicroRNA-182 targets cAMP-responsive element-binding protein 1 and suppresses cell growth in human gastric adenocarcinoma. -target gene hsa-mir-195 Breast Neoplasms 22328513 "miR-195, miR-24-2 and miR-365-2 act as negative regulators of BCL2 through direct binding to their respective binding sites in the 3' UTR of human BCL2 gene.over expression of these miRNAs not only caused an increase in apoptosis but also augmented the ap" -target gene hsa-mir-24-2 Breast Neoplasms 22328513 "miR-195, miR-24-2 and miR-365-2 act as negative regulators of BCL2 through direct binding to their respective binding sites in the 3' UTR of human BCL2 gene.over expression of these miRNAs not only caused an increase in apoptosis but also augmented the ap" -target gene hsa-mir-365b Breast Neoplasms 22328513 "miR-195, miR-24-2 and miR-365-2 act as negative regulators of BCL2 through direct binding to their respective binding sites in the 3' UTR of human BCL2 gene.over expression of these miRNAs not only caused an increase in apoptosis but also augmented the ap" -target gene hsa-mir-106a Rhabdomyosarcoma 22330340 "Downregulation of microRNAs miR-1, -206 and -29 stabilizes PAX3 and CCND2 expression in rhabdomyosarcoma." -target gene hsa-mir-1-1 Rhabdomyosarcoma 22330340 "Downregulation of microRNAs miR-1, -206 and -29 stabilizes PAX3 and CCND2 expression in rhabdomyosarcoma." -target gene hsa-mir-1-2 Rhabdomyosarcoma 22330340 "Downregulation of microRNAs miR-1, -206 and -29 stabilizes PAX3 and CCND2 expression in rhabdomyosarcoma." -target gene hsa-mir-29a Rhabdomyosarcoma 22330340 "Downregulation of microRNAs miR-1, -206 and -29 stabilizes PAX3 and CCND2 expression in rhabdomyosarcoma." -target gene hsa-mir-29b-1 Rhabdomyosarcoma 22330340 "Downregulation of microRNAs miR-1, -206 and -29 stabilizes PAX3 and CCND2 expression in rhabdomyosarcoma." -target gene hsa-mir-29b-2 Rhabdomyosarcoma 22330340 "Downregulation of microRNAs miR-1, -206 and -29 stabilizes PAX3 and CCND2 expression in rhabdomyosarcoma." -target gene hsa-mir-29c Rhabdomyosarcoma 22330340 "Downregulation of microRNAs miR-1, -206 and -29 stabilizes PAX3 and CCND2 expression in rhabdomyosarcoma." -target gene hsa-mir-29a Breast Neoplasms 22330642 "Progestin treatment decreases miR-29, thereby relieving repression of one of its direct targets, the gene encoding ATPase, Na(+)/K(+) transporting, beta 1 polypeptide (ATP1B1). ATP1B1 serves to limit migration and invasion in breast cancer cells. Lastly," -target gene hsa-mir-29b-1 Breast Neoplasms 22330642 "Progestin treatment decreases miR-29, thereby relieving repression of one of its direct targets, the gene encoding ATPase, Na(+)/K(+) transporting, beta 1 polypeptide (ATP1B1). ATP1B1 serves to limit migration and invasion in breast cancer cells. Lastly," -target gene hsa-mir-29b-2 Breast Neoplasms 22330642 "Progestin treatment decreases miR-29, thereby relieving repression of one of its direct targets, the gene encoding ATPase, Na(+)/K(+) transporting, beta 1 polypeptide (ATP1B1). ATP1B1 serves to limit migration and invasion in breast cancer cells. Lastly," -target gene hsa-mir-29c Breast Neoplasms 22330642 "Progestin treatment decreases miR-29, thereby relieving repression of one of its direct targets, the gene encoding ATPase, Na(+)/K(+) transporting, beta 1 polypeptide (ATP1B1). ATP1B1 serves to limit migration and invasion in breast cancer cells. Lastly," -target gene hsa-mir-513a-1 Breast Neoplasms 22330642 "Progestin treatment decreases miR-29, thereby relieving repression of one of its direct targets, the gene encoding ATPase, Na(+)/K(+) transporting, beta 1 polypeptide (ATP1B1). ATP1B1 serves to limit migration and invasion in breast cancer cells. Lastly," -target gene hsa-mir-513a-2 Breast Neoplasms 22330642 "Progestin treatment decreases miR-29, thereby relieving repression of one of its direct targets, the gene encoding ATPase, Na(+)/K(+) transporting, beta 1 polypeptide (ATP1B1). ATP1B1 serves to limit migration and invasion in breast cancer cells. Lastly," -target gene hsa-mir-124-1 Breast Neoplasms 22333974 "miR-124, miR-147 and miR-193a-3p are three novel tumor suppressors that co-target EGFR-driven cell-cycle network proteins and inhibit cell-cycle progression and proliferation in breast cancer." -target gene hsa-mir-124-2 Breast Neoplasms 22333974 "miR-124, miR-147 and miR-193a-3p are three novel tumor suppressors that co-target EGFR-driven cell-cycle network proteins and inhibit cell-cycle progression and proliferation in breast cancer." -target gene hsa-mir-124-3 Breast Neoplasms 22333974 "miR-124, miR-147 and miR-193a-3p are three novel tumor suppressors that co-target EGFR-driven cell-cycle network proteins and inhibit cell-cycle progression and proliferation in breast cancer." -target gene hsa-mir-147a Breast Neoplasms 22333974 "miR-124, miR-147 and miR-193a-3p are three novel tumor suppressors that co-target EGFR-driven cell-cycle network proteins and inhibit cell-cycle progression and proliferation in breast cancer." -target gene hsa-mir-193a Breast Neoplasms 22333974 "miR-124, miR-147 and miR-193a-3p are three novel tumor suppressors that co-target EGFR-driven cell-cycle network proteins and inhibit cell-cycle progression and proliferation in breast cancer." -target gene hsa-mir-24-1 Retinoblastoma 22336108 Regulation of p14ARF expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development. -target gene hsa-mir-24-2 Retinoblastoma 22336108 Regulation of p14ARF expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development. -target gene hsa-mir-141 Aortic Stenosis 22336757 miRNA-141 is a novel regulator of BMP-2-mediated calcification in aortic stenosis. -target gene hsa-mir-196a-1 Gastric Neoplasms 22343731 MiR-196a Is Up-regulated in Gastric cancer and Promotes Cell proliferation by Down-regulating p27kip1. -target gene hsa-mir-196a-2 Gastric Neoplasms 22343731 MiR-196a Is Up-regulated in Gastric cancer and Promotes Cell proliferation by Down-regulating p27kip1. -target gene hsa-mir-17 "Leukemia, Lymphocytic, Chronic, B-Cell" 22343732 The miR-17-92 family regulates the response to toll-like receptor 9 triggering of CLL cells with unmutated IGHV genes. -target gene hsa-mir-18a "Leukemia, Lymphocytic, Chronic, B-Cell" 22343732 The miR-17-92 family regulates the response to toll-like receptor 9 triggering of CLL cells with unmutated IGHV genes. -target gene hsa-mir-19a "Leukemia, Lymphocytic, Chronic, B-Cell" 22343732 The miR-17-92 family regulates the response to toll-like receptor 9 triggering of CLL cells with unmutated IGHV genes. -target gene hsa-mir-19b-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 22343732 The miR-17-92 family regulates the response to toll-like receptor 9 triggering of CLL cells with unmutated IGHV genes. -target gene hsa-mir-20a "Leukemia, Lymphocytic, Chronic, B-Cell" 22343732 The miR-17-92 family regulates the response to toll-like receptor 9 triggering of CLL cells with unmutated IGHV genes. -target gene hsa-mir-92a-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 22343732 The miR-17-92 family regulates the response to toll-like receptor 9 triggering of CLL cells with unmutated IGHV genes. -target gene hsa-mir-127 Lung Neoplasms 22349807 "Bberrant expression of miRNAs such as miR-29ab, miR-183, miR-17-5p and miR-127-3P may play an important role in regulating the bio-behavior of TICs (tumor initiating cells)." -target gene hsa-mir-17 Lung Neoplasms 22349807 "Bberrant expression of miRNAs such as miR-29ab, miR-183, miR-17-5p and miR-127-3P may play an important role in regulating the bio-behavior of TICs (tumor initiating cells)." -target gene hsa-mir-183 Lung Neoplasms 22349807 "Bberrant expression of miRNAs such as miR-29ab, miR-183, miR-17-5p and miR-127-3P may play an important role in regulating the bio-behavior of TICs (tumor initiating cells)." -target gene hsa-mir-29a Lung Neoplasms 22349807 "Bberrant expression of miRNAs such as miR-29ab, miR-183, miR-17-5p and miR-127-3P may play an important role in regulating the bio-behavior of TICs (tumor initiating cells)." -target gene hsa-mir-29b-1 Lung Neoplasms 22349807 "Bberrant expression of miRNAs such as miR-29ab, miR-183, miR-17-5p and miR-127-3P may play an important role in regulating the bio-behavior of TICs (tumor initiating cells)." -target gene hsa-mir-29b-2 Lung Neoplasms 22349807 "Bberrant expression of miRNAs such as miR-29ab, miR-183, miR-17-5p and miR-127-3P may play an important role in regulating the bio-behavior of TICs (tumor initiating cells)." -target gene hsa-mir-155 Liposarcoma 22350414 MiR-155 is a liposarcoma oncogene that targets casein kinase-1§Ø©ãand enhances §Ø©ãcatenin signaling. -target gene hsa-mir-130a "Leukemia, Lymphocytic, Chronic, B-Cell" 22350415 MicroRNA-130a targets ATG2B and DICER1 to inhibit autophagy and trigger killing of chronic lymphocytic leukemia cells. -target gene hsa-mir-21 Glioblastoma 22353043 Ursolic Acid Inhibits Proliferation and Induces Apoptosis in Human Glioblastoma Cell Lines U251 by Suppressing TGF-beta1/miR-21 /PDCD4 Pathway. -target gene hsa-mir-196b Leukemia 22353710 miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia. -target gene hsa-mir-143 Breast Neoplasms 22354042 A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells. -target gene hsa-mir-155 Breast Neoplasms 22354042 A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells. -target gene hsa-mir-203 Melanoma 22354972 Anti-oncogenic MicroRNA-203 Induces Senescence by Targeting E2F3 in Human Melanoma Cells. -target gene hsa-mir-223 Melanoma 22356618 "MiRTrail identified several deregulated miRNAs that target deregulated mRNAs including miRNAs hsa-miR-23b and hsa-miR-223, which target the highest numbers of deregulated mRNAs and regulate the pathway ""basal cell carcinoma""." -target gene hsa-mir-23b Melanoma 22356618 "MiRTrail identified several deregulated miRNAs that target deregulated mRNAs including miRNAs hsa-miR-23b and hsa-miR-223, which target the highest numbers of deregulated mRNAs and regulate the pathway ""basal cell carcinoma""." -target gene hsa-mir-212 "Carcinoma, Lung, Non-Small-Cell" 22357618 MiR-212 displays Tumor Promoting properties in NSCLC Cells and targets the Hedgehog Pathway Receptor PTCH1. -target gene hsa-mir-138-1 "Carcinoma, Hepatocellular" 22362728 MiR-138 induces cell cycle arrest by targeting cyclin D3 in hepatocellular carcinoma. -target gene hsa-mir-138-2 "Carcinoma, Hepatocellular" 22362728 MiR-138 induces cell cycle arrest by targeting cyclin D3 in hepatocellular carcinoma. -target gene hsa-mir-19a "Leukemia-Lymphoma, Adult T-Cell" 22362744 miR-19 inhibits CYLD in T-cell acute lymphoblastic leukemia. -target gene hsa-mir-19b-1 "Leukemia-Lymphoma, Adult T-Cell" 22362744 miR-19 inhibits CYLD in T-cell acute lymphoblastic leukemia. -target gene hsa-mir-19b-2 "Leukemia-Lymphoma, Adult T-Cell" 22362744 miR-19 inhibits CYLD in T-cell acute lymphoblastic leukemia. -target gene hsa-mir-34a Coronary Artery Disease 22364258 "MicroRNA-34a regulates the longevity-associated protein, SIRT1, in coronary artery disease." -target gene hsa-mir-125b-1 Leukemia 22366319 Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A. -target gene hsa-mir-125b-2 Leukemia 22366319 Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A. -target gene hsa-mir-34c "Carcinoma, Lung, Non-Small-Cell" 22370637 "The authors found a number of miRNAs (miR-17, miR-135, miR-520, miR-124-1, and miR-34c) that may rescue cell viability from caspase-8 activation. miR-34c-5p markedly increased resistance to paclitaxel-induced apoptosis. We demonstrate that Bmf (Bcl-2-modifying factor) is a target of miR-34c-5p, and that its silencing, together with that of c-myc, a known target of miR-34c-5p, contributes to resistance to apoptosis induced by paclitaxel through p53 downregulation." -target gene hsa-mir-1-1 Prostate Neoplasms 22370643 "Mir-1 and miR-200 were reduced with progression of prostate adenocarcinoma, and we identify Slug as one of the phylogenetically conserved targets of these miRs. The authors demonstrate that SLUG is a direct repressor of miR-1 and miR-200 transcription. Th" -target gene hsa-mir-1-2 Prostate Neoplasms 22370643 "Mir-1 and miR-200 were reduced with progression of prostate adenocarcinoma, and we identify Slug as one of the phylogenetically conserved targets of these miRs. The authors demonstrate that SLUG is a direct repressor of miR-1 and miR-200 transcription. Th" -target gene hsa-mir-200a Prostate Neoplasms 22370643 "Mir-1 and miR-200 were reduced with progression of prostate adenocarcinoma, and we identify Slug as one of the phylogenetically conserved targets of these miRs. The authors demonstrate that SLUG is a direct repressor of miR-1 and miR-200 transcription. Th" -target gene hsa-mir-200b Prostate Neoplasms 22370643 "Mir-1 and miR-200 were reduced with progression of prostate adenocarcinoma, and we identify Slug as one of the phylogenetically conserved targets of these miRs. The authors demonstrate that SLUG is a direct repressor of miR-1 and miR-200 transcription. Th" -target gene hsa-mir-200c Prostate Neoplasms 22370643 "Mir-1 and miR-200 were reduced with progression of prostate adenocarcinoma, and we identify Slug as one of the phylogenetically conserved targets of these miRs. The authors demonstrate that SLUG is a direct repressor of miR-1 and miR-200 transcription. Th" -target gene hsa-mir-301a "Carcinoma, Hepatocellular" 22373864 miR-301a Is a Candidate Oncogene that Targets the Homeobox Gene Gax in Human Hepatocellular Carcinoma. -target gene hsa-mir-15b Liver Failure 22374434 miR-15b and miR-16 regulate TNF mediated hepatocyte apoptosis via BCL2 in acute liver failure. -target gene hsa-mir-16-1 Liver Failure 22374434 miR-15b and miR-16 regulate TNF mediated hepatocyte apoptosis via BCL2 in acute liver failure. -target gene hsa-mir-16-2 Liver Failure 22374434 miR-15b and miR-16 regulate TNF mediated hepatocyte apoptosis via BCL2 in acute liver failure. -target gene hsa-mir-205 Nasopharyngeal Neoplasms 22374676 MiR-205 determines the radioresistance of human nasopharyngeal carcinoma by directly targeting PTEN. -target gene hsa-mir-199b "Leukemia, Myeloid, Acute" 22374871 miR-199b-5p directly targets PODXL and DDR1 and decreased levels of miR-199b-5p correlate with elevated expressions of PODXL and DDR1 in acute myeloid leukemia. -target gene hsa-mir-133a Head And Neck Neoplasms 22378351 The genome-wide gene expression analysis and bioinformatics study showed that actin-related protein 2/3 complex subunit 5 (ARPC5) is a candidate target of miR-133a. -target gene hsa-mir-1 Bladder Neoplasms 22378464 Novel molecular targets regulated by tumor suppressors microRNA-1 and microRNA-133a in bladder cancer. -target gene hsa-mir-133a Bladder Neoplasms 22378464 Novel molecular targets regulated by tumor suppressors microRNA-1 and microRNA-133a in bladder cancer. -target gene hsa-mir-335 Neuroblastoma 22382496 MiRNA-335 Suppresses Neuroblastoma Cell Invasiveness By Direct Targeting of Multiple Genes from the non-Canonical TGF-§Ø©ãSignalling Pathway. -target gene hsa-mir-506 Liver Cirrhosis 22383162 Upregulation of mir-506 leads to decreased AE2 expression in biliary epithelium of patients with primary biliary cirrhosis -target gene hsa-mir-17 Hemangiosarcoma 22383169 The miR-17-92 cluster and its target THBS1 are differentially expressed in angiosarcomas dependent on MYC amplification. -target gene hsa-mir-18a Hemangiosarcoma 22383169 The miR-17-92 cluster and its target THBS1 are differentially expressed in angiosarcomas dependent on MYC amplification. -target gene hsa-mir-19a Hemangiosarcoma 22383169 The miR-17-92 cluster and its target THBS1 are differentially expressed in angiosarcomas dependent on MYC amplification. -target gene hsa-mir-19b-1 Hemangiosarcoma 22383169 The miR-17-92 cluster and its target THBS1 are differentially expressed in angiosarcomas dependent on MYC amplification. -target gene hsa-mir-20a Hemangiosarcoma 22383169 The miR-17-92 cluster and its target THBS1 are differentially expressed in angiosarcomas dependent on MYC amplification. -target gene hsa-mir-92a-1 Hemangiosarcoma 22383169 The miR-17-92 cluster and its target THBS1 are differentially expressed in angiosarcomas dependent on MYC amplification. -target gene hsa-let-7d Pancreatic Neoplasms 22384141 The miRNA is downregulated and regulate known PDAC oncogenes -target gene hsa-mir-126 Pancreatic Neoplasms 22384141 The miRNA is downregulated and regulate known PDAC oncogenes -target gene hsa-mir-16-1 Pancreatic Neoplasms 22384141 The miRNA is downregulated and regulate known PDAC oncogenes -target gene hsa-mir-16-2 Pancreatic Neoplasms 22384141 The miRNA is downregulated and regulate known PDAC oncogenes -target gene hsa-mir-409 Gastric Neoplasms 22388101 MicroRNA-409-3p regulates cell proliferation and apoptosis by targeting PHF10 in gastric cancer. -target gene hsa-mir-216a "Carcinoma, Hepatocellular" 22392644 The androgen pathway stimulates microRNA-216a transcription to suppress the TSLC1 tumor suppressor gene in early hepatocarcinogenesis. -target gene hsa-mir-328 Hypertension 22392900 The MicroRNA-328 Regulates Hypoxic Pulmonary Hypertension by Targeting at Insulin Growth Factor 1 Receptor and L-Type Calcium Channel-alpha1C. -target gene hsa-mir-30a "Leukemia, Myeloid, Chronic-Phase" 22395361 Targeting microRNA-30a-mediated autophagy enhances imatinib activity against human chronic myeloid leukemia cells. -target gene hsa-mir-221 "Carcinoma, Hepatocellular" 22396537 SND1-induced activation of NF-kappaB resulted in induction of miR-221 and subsequent induction of angiogenic factors Angiogenin and CXCL16. Inhibition of either of these components resulted in significant inhibition of SND1-induced angiogenesis thus highlighting the importance of this molecular cascade in regulating SND1 function. -target gene hsa-mir-214 Urinary Bladder Cancer 22399294 MicroRNA-214 Suppresses The Growth and Invasiveness of Cervical Cancer Cells by Targeting UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7. -target gene hsa-mir-25 Thyroid Neoplasms 22399519 Down-Regulation of the miR-25 and miR-30d Contributes to the Development of Anaplastic Thyroid Carcinoma Targeting the Polycomb Protein EZH2. -target gene hsa-mir-30d Thyroid Neoplasms 22399519 Down-Regulation of the miR-25 and miR-30d Contributes to the Development of Anaplastic Thyroid Carcinoma Targeting the Polycomb Protein EZH2. -target gene hsa-mir-182 Medulloblastoma 22402744 "Pleiotropic effects of miR-183~96~182 converge to regulate cell survival, proliferation and migration in medulloblastoma." -target gene hsa-mir-183 Medulloblastoma 22402744 "Pleiotropic effects of miR-183~96~182 converge to regulate cell survival, proliferation and migration in medulloblastoma." -target gene hsa-mir-96 Medulloblastoma 22402744 "Pleiotropic effects of miR-183~96~182 converge to regulate cell survival, proliferation and migration in medulloblastoma." -target gene hsa-mir-133a-1 Prostate Neoplasms 22407299 "microRNA-133 inhibits cell proliferation, migration and invasion in prostate cancer cells by targeting the epidermal growth factor receptor." -target gene hsa-mir-133a-2 Prostate Neoplasms 22407299 "microRNA-133 inhibits cell proliferation, migration and invasion in prostate cancer cells by targeting the epidermal growth factor receptor." -target gene hsa-mir-133b Prostate Neoplasms 22407299 "microRNA-133 inhibits cell proliferation, migration and invasion in prostate cancer cells by targeting the epidermal growth factor receptor." -target gene hsa-mir-200c Colorectal Carcinoma 22407310 miR-200c inhibits invasion and migration in human colon cancer cells SW480/620 by targeting ZEB1.miR-200c inhibits metastatic ability by targeting ZEB1 in colon cancer cells SW480/620 and suggested that modulation of miR-200c could serve as therapeutic to -target gene hsa-mir-10a Pancreatic Neoplasms 22407312 "Based on the microarray data, the authors found frequent and marked overexpression of miR-10a, miR-92, and miR-17-5p in pancreatic cancer cell lines. MicroRNA-10a is Overexpressed in Human Pancreatic Cancer and Involved in Its Invasiveness Partially via Suppression of the HOXA1 Gene." -target gene hsa-mir-17 Pancreatic Neoplasms 22407312 "Based on the microarray data, the authors found frequent and marked overexpression of miR-10a, miR-92, and miR-17-5p in pancreatic cancer cell lines. MicroRNA-10a is Overexpressed in Human Pancreatic Cancer and Involved in Its Invasiveness Partially via Suppression of the HOXA1 Gene." -target gene hsa-mir-92a-1 Pancreatic Neoplasms 22407312 "Based on the microarray data, the authors found frequent and marked overexpression of miR-10a, miR-92, and miR-17-5p in pancreatic cancer cell lines. MicroRNA-10a is Overexpressed in Human Pancreatic Cancer and Involved in Its Invasiveness Partially via Suppression of the HOXA1 Gene." -target gene hsa-mir-27a Breast Neoplasms 22407812 "Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: Role of Sp transcription factors and microRNA-27a:ZBTB10.BA induced cell cycle arrest in the G2/M phase and increased Myt-1 mRNA (a microRNA-27a target gene), which causes inhibition in G2/M by phosphorylation of cdc2." -target gene hsa-let-7f-1 Breast Neoplasms 22407818 "Aromatase inhibitor treatment of breast cancer cells increases the expression of let-7f, a microRNA targeting CYP19A1." -target gene hsa-mir-148a Myositis Ossificans 22408438 "ACVR1, a Therapeutic Target of Fibrodysplasia Ossificans Progressiva, Is Negatively Regulated by miR-148a." -target gene hsa-mir-520h Lung Neoplasms 22410781 MiR-520h-mediated FOXC2 regulation is critical for inhibition of lung cancer progression by resveratrol. -target gene hsa-mir-365a Polycystic Kidney Disease 22411058 PKHD1 post-transcriptionally modulated by miR-365-1 inhibits cell-cell adhesion. -target gene hsa-mir-125b-1 Glioblastoma 22415301 Myc-associated zinc finger protein (MAZ) is regulated by miR-125b and mediates VEGF-induced angiogenesis in glioblastoma. -target gene hsa-mir-125b-2 Glioblastoma 22415301 Myc-associated zinc finger protein (MAZ) is regulated by miR-125b and mediates VEGF-induced angiogenesis in glioblastoma. -target gene hsa-mir-34b Melanoma 22419847 MicroRNA-34b/c suppresses uveal melanoma cell proliferation and migration through multiple targets. -target gene hsa-mir-34c Melanoma 22419847 MicroRNA-34b/c suppresses uveal melanoma cell proliferation and migration through multiple targets. -target gene hsa-mir-542 Lung Neoplasms 22426479 miR-542-5p targets EGFR and inhibited the growth of human lung cancer cells. -target gene hsa-mir-25 Glioblastoma 22431589 "In this study, two miRNAs, miR-25 and -32, are identified as p53-repressed miRNAs by p53-dependent negative regulation of their transcriptional regulators, E2F1 and MYC. However, miR-25 and -32 result in p53 accumulation by directly targeting Mdm2 and TSC1, which are negative regulators of p53." -target gene hsa-mir-32 Glioblastoma 22431589 "In this study, two miRNAs, miR-25 and -32, are identified as p53-repressed miRNAs by p53-dependent negative regulation of their transcriptional regulators, E2F1 and MYC. However, miR-25 and -32 result in p53 accumulation by directly targeting Mdm2 and TSC1, which are negative regulators of p53." -target gene hsa-mir-141 Kidney Neoplasms 22431721 "miR-192, miR-194, miR-215, miR-200c and miR-141 are downregulated and their common target ACVR2B is strongly expressed in renal childhood neoplasms." -target gene hsa-mir-192 Kidney Neoplasms 22431721 "miR-192, miR-194, miR-215, miR-200c and miR-141 are downregulated and their common target ACVR2B is strongly expressed in renal childhood neoplasms." -target gene hsa-mir-200c Kidney Neoplasms 22431721 "miR-192, miR-194, miR-215, miR-200c and miR-141 are downregulated and their common target ACVR2B is strongly expressed in renal childhood neoplasms." -target gene hsa-mir-215 Kidney Neoplasms 22431721 "miR-192, miR-194, miR-215, miR-200c and miR-141 are downregulated and their common target ACVR2B is strongly expressed in renal childhood neoplasms." -target gene hsa-let-7c "Carcinoma, Hepatocellular" 22433309 let-7c can inhibit proliferation of HCCLM3 cells and increase the proportion of cells in G1 phase. The mechanism may be that let-7c represses the expressions of cyclin D1 at both protein and mRNA levels. -target gene hsa-mir-21 Breast Neoplasms 22435731 MiR-21 regulates EMT phenotype and HIF-1§Ø©ãexpression in third-sphereforming breast cancer stem cell-like cells. -target gene hsa-mir-17 Preeclampsia 22438230 "Preeclampsia Up-Regulates Angiogenesis-Associated MicroRNA (i.e., miR-17, -20a, and -20b) That Target Ephrin-B2 and EPHB4 in Human Placenta." -target gene hsa-mir-20a Preeclampsia 22438230 "Preeclampsia Up-Regulates Angiogenesis-Associated MicroRNA (i.e., miR-17, -20a, and -20b) That Target Ephrin-B2 and EPHB4 in Human Placenta." -target gene hsa-mir-20b Preeclampsia 22438230 "Preeclampsia Up-Regulates Angiogenesis-Associated MicroRNA (i.e., miR-17, -20a, and -20b) That Target Ephrin-B2 and EPHB4 in Human Placenta." -target gene hsa-mir-135a-1 Breast Neoplasms 22439757 miRNA-135a promotes breast cancer cell migration and invasion by targeting HOXA10. -target gene hsa-mir-135a-2 Breast Neoplasms 22439757 miRNA-135a promotes breast cancer cell migration and invasion by targeting HOXA10. -target gene hsa-mir-128-1 Glioma 22442669 miR-128 expression levels were decreased in glioma. MiR-128 Inhibits Tumor Growth and Angiogenesis by Targeting p70S6K1. -target gene hsa-mir-128-2 Glioma 22442669 miR-128 expression levels were decreased in glioma. MiR-128 Inhibits Tumor Growth and Angiogenesis by Targeting p70S6K1. -target gene hsa-mir-181b-1 Liver Cirrhosis 22446332 miR-181b Promotes hepatic stellate cells proliferation by targeting p27 and is elevated in the serum of cirrhosis patients. -target gene hsa-mir-181b-2 Liver Cirrhosis 22446332 miR-181b Promotes hepatic stellate cells proliferation by targeting p27 and is elevated in the serum of cirrhosis patients. -target gene hsa-mir-328 Myopia 22447870 MicroRNA-328 may influence myopia development by mediating the PAX6 gene. -target gene hsa-mir-219 "Carcinoma, Hepatocellular" 22449976 MiR-219-5p inhibits hepatocellular carcinoma cell proliferation by targeting glypican-3. -target gene hsa-mir-20a Urinary Bladder Cancer 22449978 miR-20a promotes migration and invasion by regulating TNKS2 in human cervical cancer cells. -target gene hsa-mir-124-1 Gastric Neoplasms 22450659 MiR-124 Inhibits Cell Proliferation in Gastric Cancer through Downregulation of SPHK1. -target gene hsa-mir-124-2 Gastric Neoplasms 22450659 MiR-124 Inhibits Cell Proliferation in Gastric Cancer through Downregulation of SPHK1. -target gene hsa-mir-124-3 Gastric Neoplasms 22450659 MiR-124 Inhibits Cell Proliferation in Gastric Cancer through Downregulation of SPHK1. -target gene hsa-mir-372 Lung Neoplasms 22451061 "In addition, there is evidence that miR-372 posttranscriptionally downregulates large tumor suppressor, homolog 2 (Lats2), resulting in tumorigenesis and proliferation. " -target gene hsa-mir-133a-1 Ovarian Neoplasms 22452920 "Other pairs of potentially biological relevance include: hsa-miR-145/E2F3, hsa-miR-139-5p/TOP2A, and hsa-miR-133a/GCLC." -target gene hsa-mir-133a-2 Ovarian Neoplasms 22452920 "Other pairs of potentially biological relevance include: hsa-miR-145/E2F3, hsa-miR-139-5p/TOP2A, and hsa-miR-133a/GCLC." -target gene hsa-mir-145 Ovarian Neoplasms 22452920 "Other pairs of potentially biological relevance include: hsa-miR-145/E2F3, hsa-miR-139-5p/TOP2A, and hsa-miR-133a/GCLC." -target gene hsa-mir-328 Colorectal Carcinoma 22453125 MicroRNA expression profiling identifies miR-328 regulates cancer stem cell-like SP cells in colorectal cancer. -target gene hsa-mir-23a Colorectal Carcinoma 22455847 "MiR-23a expression promotes colon carcinoma cell growth, invasion and metastasis through inhibition of MTSS gene." -target gene hsa-mir-143 Esophageal Neoplasms 22457808 The Cluster of miR-143 and miR-145 Affects the Risk for Esophageal Squamous Cell Carcinoma through Co-Regulating Fascin Homolog 1. -target gene hsa-mir-145 Esophageal Neoplasms 22457808 The Cluster of miR-143 and miR-145 Affects the Risk for Esophageal Squamous Cell Carcinoma through Co-Regulating Fascin Homolog 1. -target gene hsa-mir-320a Colorectal Carcinoma 22459450 MicroRNA-320a suppresses human colon cancer cell proliferation by directly targeting beta-catenin. -target gene hsa-mir-125b-1 Endometrial Neoplasms 22460089 MicroRNA-125b down-regulation mediates endometrial cancer invasion by targeting ERBB2. -target gene hsa-mir-125b-2 Endometrial Neoplasms 22460089 MicroRNA-125b down-regulation mediates endometrial cancer invasion by targeting ERBB2. -target gene hsa-mir-21 Gastric Neoplasms 22464652 "MicroRNA-21 inhibits Serpini1, a gene with novel tumour suppressive effects in gastric cancer." -target gene hsa-mir-483 Glioma 22465663 MiR-483-5p suppresses the proliferation of glioma cells via directly targeting ERK1. -target gene hsa-mir-93 Ovarian Neoplasms 22465665 "Involvement of microRNA-93, a new regulator of PTEN/Akt signaling pathway, in regulation of chemotherapeutic drug cisplatin chemosensitivity in ovarian cancer cells." -target gene hsa-mir-26a-1 Lung Neoplasms 22469510 MicroRNA-26a regulates tumorigenic properties of EZH2 in human lung carcinoma cells. -target gene hsa-mir-26a-2 Lung Neoplasms 22469510 MicroRNA-26a regulates tumorigenic properties of EZH2 in human lung carcinoma cells. -target gene hsa-mir-125b-1 "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 22469780 B-cell regulator of immunoglobulin heavy chain transcription (Bright)/ARID3a is a direct target of the oncomir microRNA-125b in progenitor B-cells. -target gene hsa-mir-125b-2 "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 22469780 B-cell regulator of immunoglobulin heavy chain transcription (Bright)/ARID3a is a direct target of the oncomir microRNA-125b in progenitor B-cells. -target gene hsa-mir-495 Gastric Neoplasms 22469786 MiR-495 and miR-551a inhibit the migration and invasion of human gastric cancer cells by directly interacting with PRL-3. -target gene hsa-mir-551a Gastric Neoplasms 22469786 MiR-495 and miR-551a inhibit the migration and invasion of human gastric cancer cells by directly interacting with PRL-3. -target gene hsa-mir-183 Ovarian Neoplasms 22469921 "Tiam1, negatively regulated by miR-22, miR-183 and miR-31, is involved in migration, invasion and viability of ovarian cancer cells." -target gene hsa-mir-22 Ovarian Neoplasms 22469921 "Tiam1, negatively regulated by miR-22, miR-183 and miR-31, is involved in migration, invasion and viability of ovarian cancer cells." -target gene hsa-mir-31 Ovarian Neoplasms 22469921 "Tiam1, negatively regulated by miR-22, miR-183 and miR-31, is involved in migration, invasion and viability of ovarian cancer cells." -target gene hsa-mir-143 Head And Neck Neoplasms 22469988 miR-143 regulates hexokinase 2 expression in cancer cells. -target gene hsa-mir-155 Glioblastoma 22470130 miR-155 is up-regulated in primary and secondary glioblastoma and promotes tumour growth by inhibiting GABA receptors. -target gene hsa-mir-140 "Squamous Cell Carcinoma, Oral" 22470160 "miR-140-3p, miR-29c, and miR-29a were differentially expressed in metastasis versus nonmetastatic samples and had a strong positive correlation with their DNA copy numbers and a negative correlation with the expression of their target genes." -target gene hsa-mir-29a "Squamous Cell Carcinoma, Oral" 22470160 "miR-140-3p, miR-29c, and miR-29a were differentially expressed in metastasis versus nonmetastatic samples and had a strong positive correlation with their DNA copy numbers and a negative correlation with the expression of their target genes." -target gene hsa-mir-29c "Squamous Cell Carcinoma, Oral" 22470160 "miR-140-3p, miR-29c, and miR-29a were differentially expressed in metastasis versus nonmetastatic samples and had a strong positive correlation with their DNA copy numbers and a negative correlation with the expression of their target genes." -target gene hsa-mir-223 Gastric Neoplasms 22470493 Stathmin1 Plays Oncogenic Role and Is a Target of MicroRNA-223 in Gastric Cancer. -target gene hsa-mir-145 Osteosarcoma 22472569 MicroRNA-145 targets vascular endothelial growth factor and inhibits invasion and metastasis of osteosarcoma cells. -target gene hsa-mir-135b Prostate Neoplasms 22473899 The results show that MUC1-C activates a posttranscriptional mechanism involving miR-135b-mediated downregulation of AR mRNA levels. -target gene hsa-mir-30a Breast Neoplasms 22476851 MicroRNA-30a inhibits cell migration and invasion by downregulating vimentin expression and is a potential prognostic marker in breast cancer. -target gene hsa-mir-34a Colon Neoplasms 22479251 "miR-34a induces colon cancer apoptosis through SIRT1, and miR-34a also promotes senescence in endothelial cells via SIRT1." -target gene hsa-mir-34a Glioma 22479456 miR-34a Repression in Proneural Malignant Gliomas Upregulates Expression of Its Target PDGFRA and Promotes Tumorigenesis. -target gene hsa-mir-141 Hepatitis B Virus Infection 22479552 MicroRNA-141 Represses HBV Replication by Targeting PPARA -target gene hsa-mir-107 Myocardial Infarction 22482882 IPC enhances stem cell survival via the combined participation of hypoxia responsive miRs miR-107 and miR-210 via their respective putative target genes Pdcd10 and Casp8ap2. -target gene hsa-mir-210 Myocardial Infarction 22482882 IPC enhances stem cell survival via the combined participation of hypoxia responsive miRs miR-107 and miR-210 via their respective putative target genes Pdcd10 and Casp8ap2. -target gene hsa-mir-26a-1 Cholangiocarcinoma 22484120 MicroRNA-26a Promotes Cholangiocarcinoma Growth by Activating beta-catenin. -target gene hsa-mir-26a-2 Cholangiocarcinoma 22484120 MicroRNA-26a Promotes Cholangiocarcinoma Growth by Activating beta-catenin. -target gene hsa-mir-22 Lung Neoplasms 22484852 miR-22 suppresses lung cancer cell progression through post-transcriptional regulation of ErbB3. -target gene hsa-mir-302c Skin Neoplasms 22486352 "Co-treatment with decitabine and doxorubicin results first in increased OCT4 and mir-145, then a decrease in both, suggesting that OCT4 and mir-145 regulate each other." -target gene hsa-mir-1258 "Carcinoma, Lung, Non-Small-Cell" 22488243 The miR-1258 regulates the expression level of HPSE to influence the morbidity and metastasis of NSCLC. -target gene hsa-mir-574 Colorectal Carcinoma 22490519 miR-574-5p negatively regulates Qki6/7 to impact §Ø©ãcatenin/Wnt signalling and the development of colorectal cancer. -target gene hsa-mir-199a-1 Ovarian Neoplasms 22498306 MicroRNA-199a targets CD44 to suppress the tumorigenicity and multi-drug resistance of ovarian cancer-initiating cells. -target gene hsa-mir-199a-2 Ovarian Neoplasms 22498306 MicroRNA-199a targets CD44 to suppress the tumorigenicity and multi-drug resistance of ovarian cancer-initiating cells. -target gene hsa-mir-375 "Carcinoma, Hepatocellular" 22504094 miR-375 was down-regulated in HCC cells and tissues; it inhibited autophagy under hypoxic conditions by suppressing the conversion of LC3I to LC3II and thereby autophagic flux. -target gene hsa-mir-145 Barrett Esophagus 22504665 microRNA-145 in Barrett's oesophagus: regulating BMP4 signalling via GATA6. -target gene hsa-mir-27a Prostate Neoplasms 22505583 "Androgen regulated processing of the oncomir MiR-27a, which targets Prohibitin in prostate cancer." -target gene hsa-mir-101 Prostate Neoplasms 22505648 The repressing activity of EZH2 on RKIP expression was dependent on histone deacetylase promoter recruitment and was negatively regulated upstream by miR-101. -target gene hsa-mir-126 "Carcinoma, Lung, Non-Small-Cell" 22510476 miR-126 enhances the sensitivity of non-small cell lung cancer cells to anticancer agents by targeting vascular endothelial growth factor A. -target gene hsa-mir-204 "Carcinoma, Renal Cell" 22516261 VHL-Regulated MiR-204 Suppresses Tumor Growth through Inhibition of LC3B-Mediated Autophagy in Renal Clear Cell Carcinoma. -target gene hsa-mir-301a Demyelinating Diseases 22517757 "Both in vivo and in vitro, myelin antigen stimulation resulted in significant up-regulation of miR-301a, miR-21, and miR-155. miR-301a has a role in regulating the function of myelin-reactive T-helper type 17 cells, supporting a role for miR-301a as candidate for therapeutic targets for controlling of autoimmune demyelination." -target gene hsa-mir-298 Breast Neoplasms 22521303 Increased expression of P-glycoprotein and doxorubicin chemoresistance of metastatic breast cancer is regulated by miR-298. -target gene hsa-mir-126 Diabetes Mellitus 22525256 "Downregulation of microRNA-126 in endothelial progenitor cells from diabetes patients, impairs their functional properties, via target gene Spred-1." -target gene hsa-mir-183 Osteosarcoma 22525461 Down-regulation of miR-183 promotes migration and invasion of osteosarcoma by targeting Ezrin. -target gene hsa-mir-10b "Carcinoma, Hepatocellular" 22528944 MicroRNA-10b promotes migration and invasion through CADM1 in human hepatocellular carcinoma cells. -target gene hsa-mir-3151 "Leukemia, Myeloid, Acute" 22529287 miR-3151 interplays with its host gene BAALC and independently affects outcome of patients with cytogenetically normal acute myeloid leukemia. -target gene hsa-mir-143 Colorectal Carcinoma 22533346 MicroRNA-143 targets MACC1 to inhibit cell invasion and migration in colorectal cancer. -target gene hsa-mir-181b-1 Gastric Neoplasms 22539488 MicroRNA-181b targets cAMP responsive element binding protein 1 in gastric adenocarcinomas. -target gene hsa-mir-181b-2 Gastric Neoplasms 22539488 MicroRNA-181b targets cAMP responsive element binding protein 1 in gastric adenocarcinomas. -target gene hsa-mir-214 Cholangiocarcinoma 22540680 Downregulated miR-214 contributes to intrahepatic cholangiocarcinoma metastasis by targeting Twist. -target gene hsa-mir-143 Colorectal Carcinoma 22549179 Down-regulation of KRAS-interacting miRNA-143 predicts poor prognosis but not response to EGFR-targeted agents in colorectal cancer. -target gene hsa-mir-27a Breast Neoplasms 22553354 Betulinic Acid Targets YY1 and ErbB2 through Cannabinoid Receptor-dependent Disruption of MicroRNA-27a:ZBTB10 in Breast Cancer. -target gene hsa-mir-205 Prostate Neoplasms 22555458 miR-205 regulates basement membrane deposition in human prostate. -target gene hsa-mir-106b Leiomyoma 22556343 "miR-93/106b and Their Host Gene, MCM7, Are Differentially Expressed in Leiomyomas and Functionally Target F3 and IL-8." -target gene hsa-mir-93 Leiomyoma 22556343 "miR-93/106b and Their Host Gene, MCM7, Are Differentially Expressed in Leiomyomas and Functionally Target F3 and IL-8." -target gene hsa-mir-10a Glioblastoma 22558405 "a tumor suppressor, CSMD1, as a downstream target of miR-10a and miR-10b, two of the up-regulated miRNAs." -target gene hsa-mir-10b Glioblastoma 22558405 "a tumor suppressor, CSMD1, as a downstream target of miR-10a and miR-10b, two of the up-regulated miRNAs." -target gene hsa-mir-19a Urinary Bladder Cancer 22561557 MicroRNA-19a and -19b regulate cervical carcinoma cell proliferation and invasion by targeting CUL5. -target gene hsa-mir-19b-1 Urinary Bladder Cancer 22561557 MicroRNA-19a and -19b regulate cervical carcinoma cell proliferation and invasion by targeting CUL5. -target gene hsa-mir-19b-2 Urinary Bladder Cancer 22561557 MicroRNA-19a and -19b regulate cervical carcinoma cell proliferation and invasion by targeting CUL5. -target gene hsa-mir-9-1 Neuroblastoma 22564723 "microRNA-9 targets matrix metalloproteinase 14 to inhibit invasion, metastasis, and angiogenesis of neuroblastoma cells." -target gene hsa-mir-9-2 Neuroblastoma 22564723 "microRNA-9 targets matrix metalloproteinase 14 to inhibit invasion, metastasis, and angiogenesis of neuroblastoma cells." -target gene hsa-mir-9-3 Neuroblastoma 22564723 "microRNA-9 targets matrix metalloproteinase 14 to inhibit invasion, metastasis, and angiogenesis of neuroblastoma cells." -target gene hsa-mir-181d Glioblastoma 22570426 miR-181d: a predictive glioblastoma biomarker that downregulates MGMT expression. -target gene hsa-mir-10b Breast Neoplasms 22573479 Targeting of syndecan-1 by microRNA miR-10b promotes breast cancer cell motility and invasiveness via a Rho-GTPase- and E-cadherin-dependent mechanism. -target gene hsa-mir-139 Colorectal Carcinoma 22580051 MiR-139 inhibits invasion and metastasis of colorectal cancer by targeting the type I insulin-like growth factor receptor. -target gene hsa-mir-34a Glioblastoma 22580610 miR-34a functions as a tumor suppressor modulating EGFR in glioblastoma multiforme. -target gene hsa-mir-181a-2 Gastric Neoplasms 22581522 MicroRNA-181a promotes gastric cancer by negatively regulating tumor suppressor KLF6. -target gene hsa-mir-93 Colorectal Carcinoma 22581829 MicroRNA-93 inhibits tumor growth and early relapse of human colorectal cancer by affecting genes involved in the cell cycle. -target gene hsa-mir-381 Lung Neoplasms 22592211 MicroRNA-381 represses ID1 and is deregulated in lung adenocarcinoma. -target gene hsa-mir-145 Breast Neoplasms 22592534 MiR-145 inhibits tumor angiogenesis and growth by N-RAS and VEGF. -target gene hsa-mir-103a-1 Colorectal Carcinoma 22593189 miR-103/107 Promote Metastasis of Colorectal Cancer by Targeting the Metastasis Suppressors DAPK and KLF4. -target gene hsa-mir-103a-2 Colorectal Carcinoma 22593189 miR-103/107 Promote Metastasis of Colorectal Cancer by Targeting the Metastasis Suppressors DAPK and KLF4. -target gene hsa-mir-103b-1 Colorectal Carcinoma 22593189 miR-103/107 Promote Metastasis of Colorectal Cancer by Targeting the Metastasis Suppressors DAPK and KLF4. -target gene hsa-mir-103b-2 Colorectal Carcinoma 22593189 miR-103/107 Promote Metastasis of Colorectal Cancer by Targeting the Metastasis Suppressors DAPK and KLF4. -target gene hsa-mir-107 Colorectal Carcinoma 22593189 miR-103/107 Promote Metastasis of Colorectal Cancer by Targeting the Metastasis Suppressors DAPK and KLF4. -target gene hsa-mir-150 Adenovirus Infection 22595456 Our study demonstrates that miR-150 regulates surfactant secretion through P2X7R. -target gene hsa-mir-181a-2 "Leukemia, Lymphocytic, Chronic, B-Cell" 22610076 miR-181a/b significantly enhances drug sensitivity in chronic lymphocytic leukemia cells via targeting multiple anti-apoptosis genes. -target gene hsa-mir-181b-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 22610076 miR-181a/b significantly enhances drug sensitivity in chronic lymphocytic leukemia cells via targeting multiple anti-apoptosis genes. -target gene hsa-mir-181b-2 "Leukemia, Lymphocytic, Chronic, B-Cell" 22610076 miR-181a/b significantly enhances drug sensitivity in chronic lymphocytic leukemia cells via targeting multiple anti-apoptosis genes. -target gene hsa-mir-7-1 Gastric Neoplasms 22614005 MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulin-like growth factor-1 receptor. -target gene hsa-mir-7-2 Gastric Neoplasms 22614005 MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulin-like growth factor-1 receptor. -target gene hsa-mir-7-3 Gastric Neoplasms 22614005 MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulin-like growth factor-1 receptor. -target gene hsa-mir-27a Glioma 22614734 Lentiviral expression of anti-microRNAs targeting miR-27a inhibits proliferation and invasiveness of U87 glioma cells. -target gene hsa-mir-27b Cryptosporidium infection 22615562 miR-27b targets KSRP to coordinate TLR4-mediated epithelial defense against Cryptosporidium parvum infection. -target gene hsa-mir-181b Inflammation 22622040 MicroRNA-181b regulates NF-¦ÊB-mediated vascular inflammation. -target gene hsa-mir-21 Glioma 22630347 MicroRNA-21 expression is regulated by §Ø©ãcatenin/STAT3 pathway and promotes glioma cell invasion by direct targeting RECK. -target gene hsa-mir-10a Urinary Bladder Cancer 22634495 "MicroRNA-10a targets CHL1 and promotes cell growth, migration and invasion in human cervical cancer cells." -target gene hsa-mir-200a Pancreatic Neoplasms 22637745 Re-expression of miR-200 by novel approaches regulates the expression of PTEN and MT1-MMP in pancreatic cancer. -target gene hsa-mir-200b Pancreatic Neoplasms 22637745 Re-expression of miR-200 by novel approaches regulates the expression of PTEN and MT1-MMP in pancreatic cancer. -target gene hsa-mir-200c Pancreatic Neoplasms 22637745 Re-expression of miR-200 by novel approaches regulates the expression of PTEN and MT1-MMP in pancreatic cancer. -target gene hsa-mir-133a-1 Esophageal Neoplasms 22641236 CD47 expression regulated by the miR-133a tumor suppressor is a novel prognostic marker in esophageal squamous cell carcinoma. -target gene hsa-mir-133a-2 Esophageal Neoplasms 22641236 CD47 expression regulated by the miR-133a tumor suppressor is a novel prognostic marker in esophageal squamous cell carcinoma. -target gene hsa-mir-139 Colorectal Carcinoma 22642900 Regulation of RAP1B by miR-139 suppresses human colorectal carcinoma cell proliferation. -target gene hsa-mir-21 Prostate Neoplasms 22642976 "miR-21 may acts as an oncomir by targeting RECK, a matrix metalloproteinase regulator, in prostate cancer." -target gene hsa-mir-23b Inflammation 22660635 "The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-a." -target gene hsa-mir-26a Heart Failure 22664106 Up-regulation of miR-26a promotes apoptosis of hypoxic rat neonatal cardiomyocytes by repressing GSK-3¦Â protein expression. -target gene hsa-mir-1-1 "Carcinoma, Hepatocellular" 22664953 MicroRNA-1 and microRNA-499 downregulate the expression of the ets1 proto-oncogene in HepG2 cells. -target gene hsa-mir-1-2 "Carcinoma, Hepatocellular" 22664953 MicroRNA-1 and microRNA-499 downregulate the expression of the ets1 proto-oncogene in HepG2 cells. -target gene hsa-mir-499a "Carcinoma, Hepatocellular" 22664953 MicroRNA-1 and microRNA-499 downregulate the expression of the ets1 proto-oncogene in HepG2 cells. -target gene hsa-mir-499b "Carcinoma, Hepatocellular" 22664953 MicroRNA-1 and microRNA-499 downregulate the expression of the ets1 proto-oncogene in HepG2 cells. -target gene hsa-mir-193b Colorectal Carcinoma 22674437 "MicroRNA-199a-3p, microRNA-193b, and microRNA-320c are correlated to aging and regulate human cartilage metabolism." -target gene hsa-mir-199a-1 Colorectal Carcinoma 22674437 "MicroRNA-199a-3p, microRNA-193b, and microRNA-320c are correlated to aging and regulate human cartilage metabolism." -target gene hsa-mir-199a-2 Colorectal Carcinoma 22674437 "MicroRNA-199a-3p, microRNA-193b, and microRNA-320c are correlated to aging and regulate human cartilage metabolism." -target gene hsa-mir-320c-1 Colorectal Carcinoma 22674437 "MicroRNA-199a-3p, microRNA-193b, and microRNA-320c are correlated to aging and regulate human cartilage metabolism." -target gene hsa-mir-320c-2 Colorectal Carcinoma 22674437 "MicroRNA-199a-3p, microRNA-193b, and microRNA-320c are correlated to aging and regulate human cartilage metabolism." -target gene hsa-mir-297 Colorectal Carcinoma 22676135 miR-297 modulates multidrug resistance in human colorectal carcinoma by down-regulating MRP-2. -target gene hsa-mir-222 Colorectal Carcinoma 22677042 MiR-222 modulates multidrug resistance in human colorectal carcinoma by down-regulating ADAM-17. -target gene hsa-mir-625 Gastric Neoplasms 22677169 Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK. -target gene hsa-mir-101 "Leukemia, Lymphoblastic, Acute" 22677230 We also found that p23 was regulated by hsa-miR-101 which was down-regulated in childhood ALL cases. -target gene hsa-mir-21 Breast Neoplasms 22678116 miR-21 is targeted by omega-3 polyunsaturated fatty acid to regulate breast tumor CSF-1 expression. -target gene hsa-mir-203 Inflammation 22679274 The top-ranked predicted target of the highly down-regulated miRNA-203 in asthmatic cells was the aquaporin gene AQP4. -target gene hsa-mir-34a Glioma 22684560 MicroRNA-34a inhibits human brain glioma cell growth by down-regulation of Notch1. -target gene hsa-mir-34a Urinary Bladder Cancer 22684561 microRNA-34a inhibit cell migration and invasion of invasive urothelial bladder carcinoma by targeting Notch1. -target gene hsa-mir-15a Odontogenic Tumors 22684875 miR-15a/16-1 influences BCL2 expression in keratocystic odontogenic tumors. -target gene hsa-mir-16-1 Odontogenic Tumors 22684875 miR-15a/16-1 influences BCL2 expression in keratocystic odontogenic tumors. -target gene hsa-mir-16-2 Odontogenic Tumors 22684875 miR-15a/16-1 influences BCL2 expression in keratocystic odontogenic tumors. -target gene hsa-mir-590 "Carcinoma, Hepatocellular" 22684895 MicroRNA-590-5p regulates proliferation and invasion in human hepatocellular carcinoma cells by targeting TGF-beta RII. -target gene hsa-mir-200a Leiomyoma 22685266 "miR-200c is aberrantly expressed in leiomyomas in an ethnic-dependent manner and targets ZEBs, VEGFA, TIMP2, and FBLN5." -target gene hsa-mir-200c Leiomyoma 22685266 "miR-200c is aberrantly expressed in leiomyomas in an ethnic-dependent manner and targets ZEBs, VEGFA, TIMP2, and FBLN5." -target gene hsa-mir-93 Breast Neoplasms 22685420 MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells. -target gene hsa-mir-21 "Carcinoma, Renal Cell" 22685542 microRNA-21 governs TORC1 activation in renal cancer cell proliferation and invasion. -target gene hsa-mir-143 Colon Neoplasms 22691140 microRNA-143 down-regulates Hexokinase 2 in colon cancer cells. -target gene hsa-mir-125b-1 Breast Neoplasms 22693547 MicroRNA-125b induces metastasis by targeting STARD13 in MCF-7 and MDA-MB-231 breast cancer cells. -target gene hsa-mir-125b-2 Breast Neoplasms 22693547 MicroRNA-125b induces metastasis by targeting STARD13 in MCF-7 and MDA-MB-231 breast cancer cells. -target gene hsa-mir-30c-1 Breast Neoplasms 22701724 miR-30c overexpression inhibited proliferation of breast cancer cells.miR-30c binds the 3'UTR of KRAS transcripts and expression of pre-miR-30c down-regulated KRAS mRNA and protein. -target gene hsa-mir-30c-2 Breast Neoplasms 22701724 miR-30c overexpression inhibited proliferation of breast cancer cells.miR-30c binds the 3'UTR of KRAS transcripts and expression of pre-miR-30c down-regulated KRAS mRNA and protein. -target gene hsa-mir-34a Neuroblastoma 22703967 Inhibition of cyclin-dependent kinase 1-induced cell death in neuroblastoma cells through the microRNA-34a-MYCN-survivin pathway. -target gene hsa-mir-21 Glioblastoma 22709411 MiR-21 Modulates hTERT Through a STAT3-Dependent Manner on Glioblastoma Cell Growth. -target gene hsa-mir-23b Prostate Neoplasms 22710126 MicroRNA-23b downregulates peroxiredoxin III in human prostate cancer. -target gene hsa-mir-497 Colorectal Carcinoma 22710713 MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer. -target gene hsa-mir-632 Breast Neoplasms 22710984 Micro-RNA-632 downregulates DNAJB6 in breast cancer. -target gene hsa-mir-146a Gastric Neoplasms 22711166 microRNA-146a targets the L1 cell adhesion molecule and suppresses the metastatic potential of gastric cancer. -target gene hsa-mir-203 Breast Neoplasms 22713668 MicroRNA-203 suppresses cell proliferation and migration by targeting BIRC5 and LASP1 in human triple-negative breast cancer cells. -target gene hsa-mir-204 Nervous System Diseases [unspecific] 22718995 MicroRNA-204 critically regulates carcinogenesis in malignant peripheral nerve sheath tumors. -target gene hsa-mir-155 Gastrointestinal Neoplasms 22719182 "As a possible new mechanism underlying MSI, overexpression of miR-155 has been shown to downregulate expression of MLH1, MSH2, and MSH6. Thus, a subset of MSI-positive (MSI+) cancers without known MMR defects may result from miR-155 overexpression. " -target gene hsa-mir-195 Alzheimer Disease 22721728 MicroRNA-195 downregulates Alzheimer's disease amyloid-beta production by targeting BACE1. -target gene hsa-mir-708 Ewing Sarcoma 22723308 "EWS/FLI1 Regulates EYA3 in Ewing Sarcoma via Modulation of miRNA-708, Resulting in Increased Cell Survival and Chemoresistance." -target gene hsa-mir-195 Preeclampsia 22723898 Downregulated miR-195 detected in preeclamptic placenta affects trophoblast cell invasion via modulating ActRIIA expression. -target gene hsa-mir-137 Breast Neoplasms 22723937 MiR-137 targets estrogen-related receptor alpha and impairs the proliferative and migratory capacity of breast cancer cells. -target gene hsa-mir-337 "Carcinoma, Lung, Non-Small-Cell" 22723956 miR-337-3p and its targets STAT3 and RAP1A modulate taxane sensitivity in non-small cell lung cancers. -target gene hsa-mir-17 Urinary Bladder Cancer 22730212 MiR-17-5p targets TP53INP1 and regulates cell proliferation and apoptosis of cervical cancer cells. -target gene hsa-mir-153-1 Alzheimer Disease 22733824 MicroRNA-153 physiologically inhibits expression of amyloid-beta precursor protein in cultured human fetal brain cells and is dysregulated in a subset of Alzheimer disease patients. -target gene hsa-mir-153-2 Alzheimer Disease 22733824 MicroRNA-153 physiologically inhibits expression of amyloid-beta precursor protein in cultured human fetal brain cells and is dysregulated in a subset of Alzheimer disease patients. -target gene hsa-mir-155 Breast Neoplasms 22736789 This is the first review examining the role of miR-155 in breast cancer progression. The collated data of target genes and biologic pathways of miR-155 identified in this review suggest new avenues of research for this oncogenic miRNA. -target gene hsa-mir-138-1 Nasopharyngeal Neoplasms 22739938 MiR-138 suppressed nasopharyngeal carcinoma growth and tumorigenesis by targeting the CCND1 oncogene. -target gene hsa-mir-138-2 Nasopharyngeal Neoplasms 22739938 MiR-138 suppressed nasopharyngeal carcinoma growth and tumorigenesis by targeting the CCND1 oncogene. -target gene hsa-mir-23b Glioblastoma 22745829 miRNA expression profiling in migrating glioblastoma cells: regulation of cell migration and invasion by miR-23b via targeting of Pyk2. -target gene hsa-mir-513a-1 Lung Neoplasms 22749944 miR-513a-3p sensitizes human lung adenocarcinoma cells to chemotherapy by targeting GSTP1. -target gene hsa-mir-513a-2 Lung Neoplasms 22749944 miR-513a-3p sensitizes human lung adenocarcinoma cells to chemotherapy by targeting GSTP1. -target gene hsa-mir-410 Glioma 22750473 MiR-410 regulates MET to influence the proliferation and invasion of glioma. -target gene hsa-mir-34a Glioblastoma 22750848 microRNA Regulatory Network Inference Identifies miR-34a as a Novel Regulator of TGF-beta Signaling in Glioblastoma. -target gene hsa-mir-29a Breast Neoplasms 22751119 Progestin suppression of miR-29 potentiates dedifferentiation of breast cancer cells via KLF4. -target gene hsa-mir-29b-1 Breast Neoplasms 22751119 Progestin suppression of miR-29 potentiates dedifferentiation of breast cancer cells via KLF4. -target gene hsa-mir-29b-2 Breast Neoplasms 22751119 Progestin suppression of miR-29 potentiates dedifferentiation of breast cancer cells via KLF4. -target gene hsa-mir-29c Breast Neoplasms 22751119 Progestin suppression of miR-29 potentiates dedifferentiation of breast cancer cells via KLF4. -target gene hsa-mir-23a Lung Neoplasms 22752005 MiR-23a regulates TGF-beta-induced epithelial-mesenchymal transition by targeting E-cadherin in lung cancer cells. -target gene hsa-mir-9-1 Breast Neoplasms 22761433 MicroRNA-9 Inhibition of Cell Proliferation and Identification of Novel miR-9 Targets by Transcriptome Profiling in Breast Cancer Cells. -target gene hsa-mir-9-2 Breast Neoplasms 22761433 MicroRNA-9 Inhibition of Cell Proliferation and Identification of Novel miR-9 Targets by Transcriptome Profiling in Breast Cancer Cells. -target gene hsa-mir-9-3 Breast Neoplasms 22761433 MicroRNA-9 Inhibition of Cell Proliferation and Identification of Novel miR-9 Targets by Transcriptome Profiling in Breast Cancer Cells. -target gene hsa-mir-145 Colon Neoplasms 22766504 MiR-145 regulates PAK4 via the MAPK pathway and exhibits an antitumor effect in human colon cells. -target gene hsa-mir-138-1 "Carcinoma, Renal Cell" 22766839 Tumor suppressive microRNA-138 contributes to cell migration and invasion through its targeting of vimentin in renal cell carcinoma. -target gene hsa-mir-138-2 "Carcinoma, Renal Cell" 22766839 Tumor suppressive microRNA-138 contributes to cell migration and invasion through its targeting of vimentin in renal cell carcinoma. -target gene hsa-mir-218-1 Glioblastoma 22766851 MiR-218 reverses high invasiveness of glioblastoma cells by targeting the oncogenic transcription factor LEF1. -target gene hsa-mir-218-2 Glioblastoma 22766851 MiR-218 reverses high invasiveness of glioblastoma cells by targeting the oncogenic transcription factor LEF1. -target gene hsa-mir-125a "Carcinoma, Hepatocellular" 22768249 Ectopic expression of MiR-125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF. -target gene hsa-mir-21 Cholangiocarcinoma 22770403 PTEN and PDCD4 are bona fide targets of microRNA-21 in human cholangiocarcinoma. -target gene hsa-mir-29a Multiple Sclerosis 22772450 miR-29ab Deficiency Identifies a Negative Feedback Loop Controlling Th1 Bias That Is Dysregulated in Multiple Sclerosis. -target gene hsa-mir-29b-1 Multiple Sclerosis 22772450 miR-29ab Deficiency Identifies a Negative Feedback Loop Controlling Th1 Bias That Is Dysregulated in Multiple Sclerosis. -target gene hsa-mir-29b-2 Multiple Sclerosis 22772450 miR-29ab Deficiency Identifies a Negative Feedback Loop Controlling Th1 Bias That Is Dysregulated in Multiple Sclerosis. -target gene hsa-mir-125b-1 "Squamous Cell Carcinoma, Skin or Unspecific" 22782903 "MicroRNA-125b Down-regulates Matrix Metallopeptidase 13 and Inhibits Cutaneous Squamous Cell Carcinoma Cell Proliferation, Migration, and Invasion." -target gene hsa-mir-125b-2 "Squamous Cell Carcinoma, Skin or Unspecific" 22782903 "MicroRNA-125b Down-regulates Matrix Metallopeptidase 13 and Inhibits Cutaneous Squamous Cell Carcinoma Cell Proliferation, Migration, and Invasion." -target gene hsa-mir-103a-1 Endometrial Neoplasms 22783422 microRNA-103 regulates the growth and invasion of endometrial cancer cells through the downregulation of tissue inhibitor of metalloproteinase 3. -target gene hsa-mir-103a-2 Endometrial Neoplasms 22783422 microRNA-103 regulates the growth and invasion of endometrial cancer cells through the downregulation of tissue inhibitor of metalloproteinase 3. -target gene hsa-mir-103b-1 Endometrial Neoplasms 22783422 microRNA-103 regulates the growth and invasion of endometrial cancer cells through the downregulation of tissue inhibitor of metalloproteinase 3. -target gene hsa-mir-103b-2 Endometrial Neoplasms 22783422 microRNA-103 regulates the growth and invasion of endometrial cancer cells through the downregulation of tissue inhibitor of metalloproteinase 3. -target gene hsa-mir-20a Prostate Neoplasms 22785209 CX43 expression is suppressed by miR-20a in the progression of human prostate cancer. -target gene hsa-mir-21 Gastric Neoplasms 22792096 miR-21 Is a Promising Novel Biomarker for Lymph Node Metastasis in Patients with Gastric Cancer. -target gene hsa-mir-125b-1 Melanoma 22797068 MicroRNA miR-125b controls melanoma progression by direct regulation of c-Jun protein expression. -target gene hsa-mir-125b-2 Melanoma 22797068 MicroRNA miR-125b controls melanoma progression by direct regulation of c-Jun protein expression. -target gene hsa-mir-193b Prostate Neoplasms 22797075 CFTR suppresses tumor progression through miR-193b targeting urokinase plasminogen activator (uPA) in prostate cancer. -target gene hsa-mir-200a Thyroid Neoplasms 22797360 The miR-200 family regulates the epithelial-mesenchymal transition induced by EGF/EGFR in anaplastic thyroid cancer cells. -target gene hsa-mir-200b Thyroid Neoplasms 22797360 The miR-200 family regulates the epithelial-mesenchymal transition induced by EGF/EGFR in anaplastic thyroid cancer cells. -target gene hsa-mir-200c Thyroid Neoplasms 22797360 The miR-200 family regulates the epithelial-mesenchymal transition induced by EGF/EGFR in anaplastic thyroid cancer cells. -target gene hsa-mir-155 "Leukemia, Lymphocytic, Chronic, B-Cell" 22797699 "In the present study, we show that an 8-mer locked nucleic acid anti-miR-155 oligonucleotide targeting the seed region of miR-155 inhibits WM and chronic lymphocytic leukemia cell proliferation in vitro." -target gene hsa-mir-21 Lung Neoplasms 22806311 miR-21 induces cell cycle at S phase and modulates cell proliferation by down-regulating hMSH2 in lung cancer. -target gene hsa-mir-224 Breast Neoplasms 22809510 MicroRNA-224 targets RKIP to control cell invasion and expression of metastasis genes in human breast cancer cells. -target gene hsa-mir-107 Pituitary Neoplasms 22811466 MicroRNA miR-107 is overexpressed in pituitary adenomas and in vitro inhibits the expression of aryl hydrocarbon receptor-interacting protein (AIP). -target gene hsa-mir-324 Kidney Diseases [unspecific] 22822076 MicroRNA-324-3p Promotes Renal Fibrosis and Is a Target of ACE Inhibition. -target gene hsa-mir-124-1 "Squamous Cell Carcinoma, Skin or Unspecific" 22828925 Down-regulation of miR-124/-214 in cutaneous squamous cell carcinoma mediates abnormal cell proliferation via the induction of ERK. -target gene hsa-mir-124-2 "Squamous Cell Carcinoma, Skin or Unspecific" 22828925 Down-regulation of miR-124/-214 in cutaneous squamous cell carcinoma mediates abnormal cell proliferation via the induction of ERK. -target gene hsa-mir-214 "Squamous Cell Carcinoma, Skin or Unspecific" 22828925 Down-regulation of miR-124/-214 in cutaneous squamous cell carcinoma mediates abnormal cell proliferation via the induction of ERK. -target gene hsa-mir-146a "Leukemia, Myeloid, Acute" 22829170 "miR-146a and AMD3100, acting through different mechanism, downmodulate CXCR4 protein levels, impair leukemic cell proliferation and then may be used in combination with anti-leukemia drugs, for development of new therapeutic strategies." -target gene hsa-mir-194-1 Breast Neoplasms 22829924 Modulation of MicroRNA-194 and Cell Migration by HER2-Targeting Trastuzumab in Breast Cancer. -target gene hsa-mir-194-2 Breast Neoplasms 22829924 Modulation of MicroRNA-194 and Cell Migration by HER2-Targeting Trastuzumab in Breast Cancer. -target gene hsa-mir-21 Breast Neoplasms 22832383 Matrine Inhibits Breast Cancer Growth Via miR-21/PTEN/Akt Pathway in MCF-7 Cells. -target gene hsa-mir-126 "Carcinoma, Oral" 22836510 Downregulation of miR-126 induces angiogenesis and lymphangiogenesis by activation of VEGF-A in oral cancer. -target gene hsa-mir-130a "Carcinoma, Hepatocellular" 22846564 Upregulated miR-130a increases drug resistance by regulating RUNX3 and Wnt signaling in cisplatin-treated HCC cell. -target gene hsa-mir-203 Inflammation 22846677 "miR-203 may regulate expression of the novel nociceptive mediator PLAA after incision. Furthermore, the regulation of miR-203 and PLAA levels is reliant upon intact substance P signaling." -target gene hsa-mir-10b Breast Neoplasms 22847191 MicroRNA-10b targets E-cadherin and modulates breast cancer metastasis. -target gene hsa-mir-181a-1 Urinary Bladder Cancer 22847611 MiR-181a confers resistance of cervical cancer to radiation therapy through targeting the pro-apoptotic PRKCD gene. -target gene hsa-mir-181a-2 Urinary Bladder Cancer 22847611 MiR-181a confers resistance of cervical cancer to radiation therapy through targeting the pro-apoptotic PRKCD gene. -target gene hsa-mir-182 Melanoma 22848417 "miR-182, a p53 dependent miRNA, suppressed the expression of MITF, BCL2, cyclin D2 and functioned as a potent tumor suppressor in uveal melanoma cells." -target gene hsa-mir-31 "Carcinoma, Oral" 22854067 Passenger strand miRNA miR-31* regulates the phenotypes of oral cancer cells by targeting RhoA. -target gene hsa-mir-222 Prostate Neoplasms 22854542 Tumor suppressive microRNAs (miR-222 and miR-31) regulate molecular pathways based on microRNA expression signature in prostate cancer. -target gene hsa-mir-31 Prostate Neoplasms 22854542 Tumor suppressive microRNAs (miR-222 and miR-31) regulate molecular pathways based on microRNA expression signature in prostate cancer. -target gene hsa-mir-15a Leukemia 22856663 "we review the main achievements made on targeting of prosurvival Bcl-2 proteins through the use of different approaches, i.e. anti-sense methodology, small molecules that mimic the action of BH3 domain and microRNAs (mainly miRNA-15a and miRNA-16-1)." -target gene hsa-mir-29b-1 Breast Neoplasms 22864815 "Three mRNAs (C1QTNF6, SPARC, and COL4A2) that are down-regulated by microRNA-29b and promote invasion ability in the breast cancer cell line MCF-7." -target gene hsa-mir-29b-2 Breast Neoplasms 22864815 "Three mRNAs (C1QTNF6, SPARC, and COL4A2) that are down-regulated by microRNA-29b and promote invasion ability in the breast cancer cell line MCF-7." -target gene hsa-mir-1271 "Carcinoma, Hepatocellular" 22865282 "miR-96, miR-129-1-3p, miR-1271, miR-1291 and miR-1303 differentially control GPC3 expression in HCC cells." -target gene hsa-mir-129-1 "Carcinoma, Hepatocellular" 22865282 "miR-96, miR-129-1-3p, miR-1271, miR-1291 and miR-1303 differentially control GPC3 expression in HCC cells." -target gene hsa-mir-129-2 "Carcinoma, Hepatocellular" 22865282 "miR-96, miR-129-1-3p, miR-1271, miR-1291 and miR-1303 differentially control GPC3 expression in HCC cells." -target gene hsa-mir-1303 "Carcinoma, Hepatocellular" 22865282 "miR-96, miR-129-1-3p, miR-1271, miR-1291 and miR-1303 differentially control GPC3 expression in HCC cells." -target gene hsa-mir-96 "Carcinoma, Hepatocellular" 22865282 "miR-96, miR-129-1-3p, miR-1271, miR-1291 and miR-1303 differentially control GPC3 expression in HCC cells." -target gene hsa-mir-214 Esophageal Neoplasms 22867052 microRNA-98 and microRNA-214 post-transcriptionally regulate enhancer of zeste homolog 2 and inhibit migration and invasion in human esophageal squamous cell carcinoma. -target gene hsa-mir-98 Esophageal Neoplasms 22867052 microRNA-98 and microRNA-214 post-transcriptionally regulate enhancer of zeste homolog 2 and inhibit migration and invasion in human esophageal squamous cell carcinoma. -target gene hsa-mir-145 Glioblastoma 22869051 "NEDD9, a novel target of miR-145, increases the invasiveness of glioblastoma." -target gene hsa-mir-542 Glioma 22871495 The Putative Tumor Suppressor miR-524-5p Directly Targets Jagged-1 and Hes-1 in Glioma. -target gene hsa-mir-205 Melanoma 22871739 E2F1 confers anticancer drug resistance by targeting ABC transporter family members and Bcl-2 via the p73/DNp73-miR-205 circuitry. -target gene hsa-mir-7-1 Breast Neoplasms 22876288 MicroRNA-7 Inhibits Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer Cells via Targeting FAK Expression. -target gene hsa-mir-7-2 Breast Neoplasms 22876288 MicroRNA-7 Inhibits Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer Cells via Targeting FAK Expression. -target gene hsa-mir-7-3 Breast Neoplasms 22876288 MicroRNA-7 Inhibits Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer Cells via Targeting FAK Expression. -target gene hsa-mir-196a-1 "Carcinoma, Lung, Non-Small-Cell" 22876840 MicroRNA-196a promotes non-small cell lung cancer cell proliferation and invasion through targeting HOXA5. -target gene hsa-mir-196a-2 "Carcinoma, Lung, Non-Small-Cell" 22876840 MicroRNA-196a promotes non-small cell lung cancer cell proliferation and invasion through targeting HOXA5. -target gene hsa-mir-1 Coronary Artery Disease 22883088 Association study on the microRNA-1 target gene polymorphism and the risk of premature coronary artery disease -target gene hsa-mir-137 Schizophrenia 22883350 Candidate schizophrenia gene ZNF804A is a target for hsa-miR-137. -target gene hsa-mir-133b "Carcinoma, Lung, Non-Small-Cell" 22883469 MicroRNA-133b Inhibits the Growth of Non-small Cell Lung Cancer by Targeting the Epidermal Growth Factor Receptor. -target gene hsa-mir-26a-1 Lung Neoplasms 22885155 MiR-26a enhances metastasis potential of lung cancer cells via AKT pathway by targeting PTEN. -target gene hsa-mir-26a-2 Lung Neoplasms 22885155 MiR-26a enhances metastasis potential of lung cancer cells via AKT pathway by targeting PTEN. -target gene hsa-mir-203 "Carcinoma, Hepatocellular" 22886454 miR-203 inhibits proliferation of hepatocellular carcinoma cells by targeting survivin. -target gene hsa-mir-335 Meningioma 22886530 miR-335 promotes cell proliferation by directly targeting Rb1 in meningiomas. -target gene hsa-mir-195 "Carcinoma, Hepatocellular" 22888524 MiR-195 regulates cell apoptosis of human hepatocellular carcinoma cells by targeting LATS2. -target gene hsa-mir-24 Heart Failure 22891046 MiR-24-mediated suppression of JP2 expression provides a novel molecular mechanism for E-C coupling regulation in heart cells and suggests a new target against heart failure. -target gene hsa-mir-124-1 Colorectal Carcinoma 22895557 "miR-124, miR-137 and miR-340 regulate colorectal cancer growth via inhibition of the Warburg effect." -target gene hsa-mir-124-2 Colorectal Carcinoma 22895557 "miR-124, miR-137 and miR-340 regulate colorectal cancer growth via inhibition of the Warburg effect." -target gene hsa-mir-137 Colorectal Carcinoma 22895557 "miR-124, miR-137 and miR-340 regulate colorectal cancer growth via inhibition of the Warburg effect." -target gene hsa-mir-340 Colorectal Carcinoma 22895557 "miR-124, miR-137 and miR-340 regulate colorectal cancer growth via inhibition of the Warburg effect." -target gene hsa-mir-92a-1 Glioblastoma 22895567 miR-92a is a critical regulator of the apoptosis pathway in glioblastoma with inverse expression of BCL2L11. -target gene hsa-mir-92a-2 Glioblastoma 22895567 miR-92a is a critical regulator of the apoptosis pathway in glioblastoma with inverse expression of BCL2L11. -target gene hsa-mir-132 Dementia 22895706 "TMEM106B, the Risk Gene for Frontotemporal Dementia, Is Regulated by the microRNA-132/212 Cluster and Affects Progranulin Pathways." -target gene hsa-mir-212 Dementia 22895706 "TMEM106B, the Risk Gene for Frontotemporal Dementia, Is Regulated by the microRNA-132/212 Cluster and Affects Progranulin Pathways." -target gene hsa-mir-140 "Carcinoma, Hepatocellular" 22898998 MiRNA-140 acts as a liver tumor suppressor by controlling NF-kB activity via directly targeting Dnmt1 expression. -target gene hsa-mir-370 "Leukemia, Myeloid, Acute" 22900969 The tumor suppressive role of miRNA-370 by targeting FoxM1 in acute myeloid leukemia. -target gene hsa-mir-193a Endometrial Neoplasms 22907428 YY1 overexpression was found to be a consequence of miR-193a-5p downregulation through direct miR-193a-5p-YY1 interplay. -target gene hsa-mir-331 Prostate Neoplasms 22908221 "Regulation of expression of deoxyhypusine hydroxylase (DOHH), the enzyme that catalyzes the activation of eIF5A, by miR-331-3p and miR-642-5p in prostate cancer cells." -target gene hsa-mir-642a Prostate Neoplasms 22908221 "Regulation of expression of deoxyhypusine hydroxylase (DOHH), the enzyme that catalyzes the activation of eIF5A, by miR-331-3p and miR-642-5p in prostate cancer cells." -target gene hsa-mir-642b Prostate Neoplasms 22908221 "Regulation of expression of deoxyhypusine hydroxylase (DOHH), the enzyme that catalyzes the activation of eIF5A, by miR-331-3p and miR-642-5p in prostate cancer cells." -target gene hsa-mir-128-1 Ovarian Neoplasms 22909061 "Both miR-128 and miR-152 down-regulate CSF-1 mRNA and protein expression in ovarian cancer cells leading to decreased cell motility and adhesion in vitro, two major aspects of the metastatic potential of cancer cells." -target gene hsa-mir-128-2 Ovarian Neoplasms 22909061 "Both miR-128 and miR-152 down-regulate CSF-1 mRNA and protein expression in ovarian cancer cells leading to decreased cell motility and adhesion in vitro, two major aspects of the metastatic potential of cancer cells." -target gene hsa-mir-24-2 Breast Neoplasms 22911661 Preferential star strand biogenesis of pre-miR-24-2 targets PKC-alpha and suppresses cell survival in MCF-7 breast cancer cells. -target gene hsa-mir-106a Colorectal Carcinoma 22912877 "MiR-106a inhibits the expression of transforming growth factor-beta receptor 2 (TGFBR2), leading to increased CRC cell migration and invasion. Importantly, miR-106a expression levels in primary CRCs are correlated with clinical cancer progression." -target gene hsa-mir-122 Prostate Neoplasms 22914437 "miR122 regulation of Ad6 significantly improves its safety profile after systemic administration, which allows increasing therapeutic doses leading to improved anticancer efficacy of systemic treatment for castration-resistant prostate cancer." -target gene hsa-mir-10b Neoplasms [unspecific] 22915757 "MiR-10b downregulates the stress-induced cell surface molecule MICB, a critical ligand for cancer cell recognition by natural killer cells." -target gene hsa-let-7c Atherosclerosis 22917031 Our data suggest that let-7c contributes to endothelial apoptosis through suppression of Bcl-xl -target gene hsa-mir-182 Peripheral Nerve Injury 22917588 "Our data indicate that nerve injury inhibits SC proliferation and migration through rapid regulation of miR-182 by targeting FGF9 and NTM, providing novel insights into the roles of miRNAs in nerve injury and repair." -target gene hsa-mir-203 Psoriasis 22917968 Our findings suggest that miR-203 serves to fine-tune cytokine signaling and may dampen skin immune responses by repressing key pro-inflammatory cytokines. -target gene hsa-mir-183 Osteosarcoma 22922800 miR-183 inhibits the metastasis of osteosarcoma via downregulation of the expression of Ezrin in F5M2 cells. -target gene hsa-mir-15a Osteosarcoma 22922827 miR-15a and miR-16-1 downregulate CCND1 and induce apoptosis and cell cycle arrest in osteosarcoma. -target gene hsa-mir-16-1 Osteosarcoma 22922827 miR-15a and miR-16-1 downregulate CCND1 and induce apoptosis and cell cycle arrest in osteosarcoma. -target gene hsa-mir-100 Breast Neoplasms 22926517 miR-100 suppresses IGF2 and inhibits breast tumorigenesis by interfering with proliferation and survival signaling. -target gene hsa-mir-214 Ovarian Neoplasms 22927443 MiR-214 regulates ovarian cancer cell stemness by targeting p53/nanog. -target gene hsa-mir-214 "Carcinoma, Lung, Non-Small-Cell" 22929890 "miRNA-214 modulates radiotherapy response of non-small cell lung cancer cells through regulation of p38MAPK, apoptosis and senescence." -target gene hsa-mir-29b-1 Nervous System Diseases [unspecific] 22932723 Exosome-mediated shuttling of microRNA-29b regulates HIV Tat and morphine-mediated Neuronal dysfunction. -target gene hsa-mir-29b-2 Nervous System Diseases [unspecific] 22932723 Exosome-mediated shuttling of microRNA-29b regulates HIV Tat and morphine-mediated Neuronal dysfunction. -target gene hsa-mir-544a Gastric Neoplasms 22934698 Oncogenic miR-544 is an Important Molecular Target in Gastric Cancer. -target gene hsa-mir-544b Gastric Neoplasms 22934698 Oncogenic miR-544 is an Important Molecular Target in Gastric Cancer. -target gene hsa-mir-148a Breast Neoplasms 22935141 "Overexpression of miR-148a or miR-152 significantly inhibits BC cell proliferation, colony formation and tumor angiogenesis via targeting IGF-IR and IRS1 and suppressing their downstream AKT and MAPK/ERK signaling pathways." -target gene hsa-mir-152 Breast Neoplasms 22935141 "Overexpression of miR-148a or miR-152 significantly inhibits BC cell proliferation, colony formation and tumor angiogenesis via targeting IGF-IR and IRS1 and suppressing their downstream AKT and MAPK/ERK signaling pathways." -target gene hsa-mir-124-1 "Carcinoma, Hepatocellular" 22940133 MiR-124 suppresses cell proliferation in hepatocellular carcinoma by targeting PIK3CA. -target gene hsa-mir-124-2 "Carcinoma, Hepatocellular" 22940133 MiR-124 suppresses cell proliferation in hepatocellular carcinoma by targeting PIK3CA. -target gene hsa-mir-203 Esophageal Neoplasms 22940702 miR-203 inhibits the migration and invasion of esophageal squamous cell carcinoma by regulating LASP1. -target gene hsa-mir-338 Hepatitis B Virus Infection 22942717 miR-338-3p Is Down-Regulated by Hepatitis B Virus X and Inhibits Cell Proliferation by Targeting the 3'-UTR Region of CyclinD1. -target gene hsa-mir-205 Prostate Neoplasms 22949650 Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. -target gene hsa-mir-19a Breast Neoplasms 22952885 "These results suggest that the IMPDH1 and NPEPL1 genes are direct targets of miR-19a in breast cancer, while the exogenous expression of these genes is not associated with the growth suppression of MCF-7 cells." -target gene hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 22956424 "MicroRNA-21 (miR-21) expression promotes growth, metastasis, and chemo- or radioresistance in non-small cell lung cancer cells by targeting PTEN." -target gene hsa-mir-181a Atherosclerosis 22956783 "Thus, abundance of miR-181a reduced c-Fos protein, whereas inhibition of miR-181a increased c-Fos protein in BMDCs. We therefore suggest that miR-181a attenuates ox-LDL-stimulated immune inflammation responses by targeting c-Fos in DCs." -target gene hsa-mir-122 Hepatitis C Virus Infection 22957141 Silencing of microRNA-122 enhances interferon-alpha signaling in the liver through regulating SOCS3 promoter methylation. -target gene hsa-let-7a Lung Neoplasms 22970031 "The upregulation of let-7a/7g repressed the expression of their targets,C-MYC and the regulatory protein of LIN-28, at the mRNA and protein levels." -target gene hsa-let-7g Lung Neoplasms 22970031 "The upregulation of let-7a/7g repressed the expression of their targets,C-MYC and the regulatory protein of LIN-28, at the mRNA and protein levels." -target gene hsa-mir-16 "Leukemia, Myeloid, Acute" 22970245 our data demonstrated that over-expression of miR-16 mimics suppressed Pim-1 expression in FD-FLT3/ITD cells suggesting that increased miR-16 expression contributes to depletion of Pim-1 after FLT3 inhibition and that miR-16 repression may be associated with up-regulated Pim-1 in FLT3/ITD expressing cells. -target gene hsa-mir-101 Lung Neoplasms 22977606 Overexpression of miR-101 induced a marked reduction in EZH2 mRNA levels in several lung cancer cell lines -target gene hsa-mir-200c Melanoma 22982443 miR-200c inhibits melanoma progression and drug resistance through down-regulation of BMI-1. -target gene hsa-mir-10a "Carcinoma, Hepatocellular" 22996586 Our findings highlight the importance of miR-10a in regulating the metastatic properties of HCC by directly targeting EphA4 and may provide new insights into the pathogenesis of HCC -target gene hsa-mir-34a Breast Neoplasms 23001043 Our results demonstrate that miR-34a/c functions as a metastasis suppressor to regulate breast cancer migration and invasion through targeting Fra-1 oncogene and suggest a therapeutic application of miR-34 in breast cancer. -target gene hsa-mir-34c Breast Neoplasms 23001043 Our results demonstrate that miR-34a/c functions as a metastasis suppressor to regulate breast cancer migration and invasion through targeting Fra-1 oncogene and suggest a therapeutic application of miR-34 in breast cancer. -target gene hsa-mir-494 "Carcinoma, Lung, Non-Small-Cell" 23012423 MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non-small-cell lung cancer through BIM down-regulation. -target gene hsa-mir-125a Myeloproliferative Neoplasms 23012470 "we demonstrate that miR-125a targets multiple protein phosphatases. Our data demonstrate that miR-125a-induced MPN is addicted to its sustained overexpression, and highlight the complex nature of oncogenic miRNA dependence in an early neoplastic state." -target gene hsa-let-7c Bladder Neoplasms 23013190 "Expression of 5 miRNAs (miR-34a, let-7c, miR-16, miR-103b, and miR-106b) that target p53, Rb, or Bcl-2 protein pathways was determined for bladder samples and cells via quantitative real-time PCR assay." -target gene hsa-mir-103b Bladder Neoplasms 23013190 "Expression of 5 miRNAs (miR-34a, let-7c, miR-16, miR-103b, and miR-106b) that target p53, Rb, or Bcl-2 protein pathways was determined for bladder samples and cells via quantitative real-time PCR assay." -target gene hsa-mir-106b Bladder Neoplasms 23013190 "Expression of 5 miRNAs (miR-34a, let-7c, miR-16, miR-103b, and miR-106b) that target p53, Rb, or Bcl-2 protein pathways was determined for bladder samples and cells via quantitative real-time PCR assay." -target gene hsa-mir-16 Bladder Neoplasms 23013190 "Expression of 5 miRNAs (miR-34a, let-7c, miR-16, miR-103b, and miR-106b) that target p53, Rb, or Bcl-2 protein pathways was determined for bladder samples and cells via quantitative real-time PCR assay." -target gene hsa-mir-34a Bladder Neoplasms 23013190 "Expression of 5 miRNAs (miR-34a, let-7c, miR-16, miR-103b, and miR-106b) that target p53, Rb, or Bcl-2 protein pathways was determined for bladder samples and cells via quantitative real-time PCR assay." -target gene hsa-mir-135a "Carcinoma, Rectal" 23017832 MiR-135a promotes growth and invasion of colorectal cancer via metastasis suppressor 1 in vitro. -target gene hsa-mir-146a Psoriasis 23018031 Inability of miR-146a inhibiting target gene IRAK1 may contribute to the persistent inflammation in lesions of psoriasis. -target gene hsa-mir-200c Vascular Hypertrophy 23020145 "Increased miR-21 and miR-200c contents were associated with reduced expression of their targets, Sprouty-1 and ZEB2, respectively." -target gene hsa-mir-21 Vascular Hypertrophy 23020145 "Increased miR-21 and miR-200c contents were associated with reduced expression of their targets, Sprouty-1 and ZEB2, respectively." -target gene hsa-mir-128 "Leukemia, Myeloid, Acute" 23022987 "A Renilla-luciferase assay and flow cytometry after transfection with pre-microRNAs confirmed that RET is regulated by miR-218, miR-128, miR-27b, miR-15a and miR-195." -target gene hsa-mir-15a "Leukemia, Myeloid, Acute" 23022987 "A Renilla-luciferase assay and flow cytometry after transfection with pre-microRNAs confirmed that RET is regulated by miR-218, miR-128, miR-27b, miR-15a and miR-195." -target gene hsa-mir-195 "Leukemia, Myeloid, Acute" 23022987 "A Renilla-luciferase assay and flow cytometry after transfection with pre-microRNAs confirmed that RET is regulated by miR-218, miR-128, miR-27b, miR-15a and miR-195." -target gene hsa-mir-218 "Leukemia, Myeloid, Acute" 23022987 "A Renilla-luciferase assay and flow cytometry after transfection with pre-microRNAs confirmed that RET is regulated by miR-218, miR-128, miR-27b, miR-15a and miR-195." -target gene hsa-mir-27b "Leukemia, Myeloid, Acute" 23022987 "A Renilla-luciferase assay and flow cytometry after transfection with pre-microRNAs confirmed that RET is regulated by miR-218, miR-128, miR-27b, miR-15a and miR-195." -target gene hsa-mir-1 Heart Failure 23024758 "Time-course analysis revealed that decreased expression of miR-1 and miR-133a commences at a pre-disease stage, and precedes upregulation of target genes causal of cardiac hypertrophy and extracellular matrix remodelling, suggesting a role for miR-1 and miR-133a in early disease development." -target gene hsa-mir-133a Heart Failure 23024758 "Time-course analysis revealed that decreased expression of miR-1 and miR-133a commences at a pre-disease stage, and precedes upregulation of target genes causal of cardiac hypertrophy and extracellular matrix remodelling, suggesting a role for miR-1 and miR-133a in early disease development." -target gene hsa-mir-155 Atherosclerosis 23041630 MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages -target gene hsa-mir-141 Ovarian Neoplasms 23045278 miR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cells -target gene hsa-mir-145 Breast Neoplasms 23049906 MiR-145 regulates epithelial to mesenchymal transition of breast cancer cells by targeting Oct4 -target gene hsa-mir-1280 Urinary Bladder Cancer 23056431 MicroRNA-1280 inhibits invasion and metastasis by targeting ROCK1 in bladder cancer -target gene hsa-mir-17 Leukemia 23056458 we demonstrated that physiological re-expression of exogenous miR-17 and miR-20a are able to partially rescue the proliferation loss induced by Fli-1 knock-down and identified HBP1 as a target of these miRNA in erythroleukemic cells. -target gene hsa-mir-20a Leukemia 23056458 we demonstrated that physiological re-expression of exogenous miR-17 and miR-20a are able to partially rescue the proliferation loss induced by Fli-1 knock-down and identified HBP1 as a target of these miRNA in erythroleukemic cells. -target gene hsa-mir-122 Breast Neoplasms 23056576 MiR-122 inhibits cell proliferation and tumorigenesis of breast cancer by targeting IGF1R -target gene hsa-mir-17 "Leukemia, Myeloid" 23059786 HIF-1a downregulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation -target gene hsa-mir-20a "Leukemia, Myeloid" 23059786 HIF-1a downregulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation -target gene hsa-mir-153-1 Prostate Neoplasms 23060044 Upregulation of miR-153 promotes cell proliferation via downregulation of the PTEN tumor suppressor gene in human prostate cancer -target gene hsa-mir-153-2 Prostate Neoplasms 23060044 Upregulation of miR-153 promotes cell proliferation via downregulation of the PTEN tumor suppressor gene in human prostate cancer -target gene hsa-mir-214 "Carcinoma, Hepatocellular" 23068095 MiR-214 inhibits cell growth in hepatocellular carcinoma through suppression of beta-catenin -target gene hsa-mir-198 Prostate Neoplasms 23069480 Livin expression may be regulated by miR-198 in human prostate cancer cell lines -target gene hsa-mir-124-1 Prostate Neoplasms 23069658 Tumor suppressive miR-124 targets androgen receptor and inhibits proliferation of prostate cancer cells -target gene hsa-mir-124-2 Prostate Neoplasms 23069658 Tumor suppressive miR-124 targets androgen receptor and inhibits proliferation of prostate cancer cells -target gene hsa-mir-124-3 Prostate Neoplasms 23069658 Tumor suppressive miR-124 targets androgen receptor and inhibits proliferation of prostate cancer cells -target gene hsa-mir-133a Cardiac Myocyte Injury 23069713 We also discovered that luciferase activity is exclusively decreased by targeting EGFR in hMSCs transfected with miR-133a mimic. These results suggest that EGFR plays a key role in the regulation of cardiogenic differentiation in hMSCs. -target gene hsa-mir-1297 Lung Neoplasms 23071539 miR-511 and miR-1297 inhibit human lung adenocarcinoma cell proliferation by targeting oncogene TRIB2 -target gene hsa-mir-511 Lung Neoplasms 23071539 miR-511 and miR-1297 inhibit human lung adenocarcinoma cell proliferation by targeting oncogene TRIB2 -target gene hsa-mir-101-1 Breast Neoplasms 23071542 MiR-101 is involved in human breast carcinogenesis by targeting Stathmin1 -target gene hsa-mir-101-2 Breast Neoplasms 23071542 MiR-101 is involved in human breast carcinogenesis by targeting Stathmin1 -target gene hsa-mir-203 Lung Neoplasms 23073851 miR-203 negatively regulates survivin protein expression and inhibits the proliferation and invasion of lung cancer cells -target gene hsa-mir-145 Glioma 23076445 MiR-145 reduces ADAM17 expression and inhibits in vitro migration and invasion of glioma cells -target gene hsa-mir-125a "Carcinoma, Hepatocellular" 23079745 SIRT7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors mir-125a-5p and mir-125b -target gene hsa-mir-125b-1 "Carcinoma, Hepatocellular" 23079745 SIRT7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors mir-125a-5p and mir-125b -target gene hsa-mir-125b-2 "Carcinoma, Hepatocellular" 23079745 SIRT7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors mir-125a-5p and mir-125b -target gene hsa-mir-21 Neuroblastoma 23084187 Micro-RNA-21 regulates the sensitivity to cisplatin in human neuroblastoma cells -target gene hsa-mir-34a Breast Neoplasms 23085450 MicroRNA-34a modulates chemosensitivity of breast cancer cells to adriamycin by targeting Notch1 -target gene hsa-mir-181a-1 Neoplasms [unspecific] 23085757 "miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer" -target gene hsa-mir-181a-2 Neoplasms [unspecific] 23085757 "miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer" -target gene hsa-mir-199a-1 Neoplasms [unspecific] 23085757 "miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer" -target gene hsa-mir-199a-2 Neoplasms [unspecific] 23085757 "miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer" -target gene hsa-mir-30d Neoplasms [unspecific] 23085757 "miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer" -target gene hsa-mir-17 Prostate Neoplasms 23095762 miR-17-5p targets the p300/CBP-associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells -target gene hsa-mir-26a-1 "Leukemia, Myeloid, Acute" 23096114 The microRNA-26a target E2F7 sustains cell proliferation and inhibits monocytic differentiation of acute myeloid leukemia cells -target gene hsa-mir-26a-2 "Leukemia, Myeloid, Acute" 23096114 The microRNA-26a target E2F7 sustains cell proliferation and inhibits monocytic differentiation of acute myeloid leukemia cells -target gene hsa-mir-181a-2 "Leukemia, Myeloid, Acute" 23100311 Lenalidomide-mediated enhanced translation of C/EBPalpha-p30 protein up-regulates expression of the antileukemic microRNA-181a in acute myeloid leukemia -target gene hsa-mir-133a Ischemia-Reperfusion Injury 23102905 "Therefore, targeting of microRNA-133a represents a potentially novel means for regulating the cascade of profibrotic events after ischemia-reperfusion." -target gene hsa-mir-15a Multiple Myeloma 23104180 miR-15a and miR-16 affect the angiogenesis of multiple myeloma by targeting VEGF -target gene hsa-mir-16-1 Multiple Myeloma 23104180 miR-15a and miR-16 affect the angiogenesis of multiple myeloma by targeting VEGF -target gene hsa-mir-16-2 Multiple Myeloma 23104180 miR-15a and miR-16 affect the angiogenesis of multiple myeloma by targeting VEGF -target gene hsa-mir-143 Urinary Bladder Cancer 23104321 Replacement treatment with microRNA-143 and -145 induces synergistic inhibition of the growth of human bladder cancer cells by regulating PI3K/Akt and MAPK signaling pathways -target gene hsa-mir-145 Urinary Bladder Cancer 23104321 Replacement treatment with microRNA-143 and -145 induces synergistic inhibition of the growth of human bladder cancer cells by regulating PI3K/Akt and MAPK signaling pathways -target gene hsa-mir-21 Laryngeal Neoplasms 23104547 Downregulation of miR-21 regulates MMP-2 expression and suppress migration of Laryngeal squamous cell carcinoma -target gene hsa-mir-210 Neuroblastoma 23108914 MicroRNA-210 targets antiapoptotic Bcl-2 expression and mediates hypoxia-induced apoptosis of neuroblastoma cells -target gene hsa-mir-26a-1 Esophageal Neoplasms 23108995 MiR-26a regulates cell cycle and anoikis of human esophageal adenocarcinoma cells through Rb1-E2F1 signaling pathway -target gene hsa-mir-26a-2 Esophageal Neoplasms 23108995 MiR-26a regulates cell cycle and anoikis of human esophageal adenocarcinoma cells through Rb1-E2F1 signaling pathway -target gene hsa-mir-429 Colorectal Carcinoma 23111103 MiR-429 is an independent prognostic factor in colorectal cancer and exerts its anti-apoptotic function by targeting SOX2 -target gene hsa-mir-29a Osteosarcoma 23113351 data obtained highlight the role of miRNA-29a in the regulation of osteoblastic cell apoptosis by silencing Bcl-2 and Mcl-1 and inducing E2F1 and E2F3 expression -target gene hsa-mir-29a "Leukemia, Myeloid, Chronic-Phase" 23113544 Regulation of Human RNase-L by the miR-29 Family Reveals a Novel Oncogenic Role in Chronic Myelogenous Leukemia -target gene hsa-mir-29b-1 "Leukemia, Myeloid, Chronic-Phase" 23113544 Regulation of Human RNase-L by the miR-29 Family Reveals a Novel Oncogenic Role in Chronic Myelogenous Leukemia -target gene hsa-mir-29b-2 "Leukemia, Myeloid, Chronic-Phase" 23113544 Regulation of Human RNase-L by the miR-29 Family Reveals a Novel Oncogenic Role in Chronic Myelogenous Leukemia -target gene hsa-mir-27a Lung Neoplasms 23117485 miR-27a regulates the self renewal of the H446 small cell lung cancer cell line in vitro -target gene hsa-mir-144 Nasopharyngeal Neoplasms 23125220 "MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN" -target gene hsa-mir-205 Parkinson Disease 23125283 MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein -target gene hsa-mir-17 Sarcoma [unspecific] 23128393 "Interestingly, the levels of onco-miR-17 locus coded miRNAs (miR-17-5p and miR-20a) were decreased upon TAF15 depletion and shown to affect the post-transcriptional regulation of TAF15-dependent genes,such as CDKN1A/p21." -target gene hsa-mir-20a Sarcoma [unspecific] 23128393 "Interestingly, the levels of onco-miR-17 locus coded miRNAs (miR-17-5p and miR-20a) were decreased upon TAF15 depletion and shown to affect the post-transcriptional regulation of TAF15-dependent genes,such as CDKN1A/p21." -target gene hsa-mir-574 Lung Neoplasms 23133627 MicroRNA-574-5p was pivotal for TLR9 signaling enhanced tumor progression via down-regulating checkpoint suppressor 1 in human lung cancer -target gene hsa-mir-7-1 Lung Neoplasms 23135998 "MicroRNA-7-regulated TLR9 signaling-enhanced growth and metastatic potential of human lung cancer cells by altering the phosphoinositide-3-kinase, regulatory subunit 3/Akt pathway" -target gene hsa-mir-7-2 Lung Neoplasms 23135998 "MicroRNA-7-regulated TLR9 signaling-enhanced growth and metastatic potential of human lung cancer cells by altering the phosphoinositide-3-kinase, regulatory subunit 3/Akt pathway" -target gene hsa-mir-7-3 Lung Neoplasms 23135998 "MicroRNA-7-regulated TLR9 signaling-enhanced growth and metastatic potential of human lung cancer cells by altering the phosphoinositide-3-kinase, regulatory subunit 3/Akt pathway" -target gene hsa-let-7a Ovarian Neoplasms 23136250 The hsa-let-7 family member hsa-let-7a is a modulator of KLK6 protein expression that is independent of the KLK6 copy number status. -target gene hsa-mir-186 Colorectal Carcinoma 23137536 "miR-186, miR-216b, miR-337-3p, and miR-760 cooperatively induce cellular senescence by targeting alpha subunit of protein kinase CKII in human colorectal cancer cells" -target gene hsa-mir-216b Colorectal Carcinoma 23137536 "miR-186, miR-216b, miR-337-3p, and miR-760 cooperatively induce cellular senescence by targeting alpha subunit of protein kinase CKII in human colorectal cancer cells" -target gene hsa-mir-337 Colorectal Carcinoma 23137536 "miR-186, miR-216b, miR-337-3p, and miR-760 cooperatively induce cellular senescence by targeting alpha subunit of protein kinase CKII in human colorectal cancer cells" -target gene hsa-mir-760 Colorectal Carcinoma 23137536 "miR-186, miR-216b, miR-337-3p, and miR-760 cooperatively induce cellular senescence by targeting alpha subunit of protein kinase CKII in human colorectal cancer cells" -target gene hsa-mir-196a-1 Colorectal Carcinoma 23138850 "miR-186, miR-216b, miR-337-3p, and miR-760 cooperatively induce cellular senescence by targeting alpha subunit of protein kinase CKII in human colorectal cancer cells" -target gene hsa-mir-196a-2 Colorectal Carcinoma 23138850 "miR-186, miR-216b, miR-337-3p, and miR-760 cooperatively induce cellular senescence by targeting alpha subunit of protein kinase CKII in human colorectal cancer cells" -target gene hsa-mir-197 Pancreatic Neoplasms 23139153 MiR-197 induces epithelial-mesenchymal transition in pancreatic cancer cells by targeting p120 catenin -target gene hsa-mir-1 Heart Failure 23141496 Biochemical assays and an inducible cardiac-specific transgenic mouse model overexpressing miR-1 were used to demonstrate that heart-type fatty acid-binding protein-3 (FABP3) is a target of miR-1. -target gene hsa-mir-1-1 Lung Neoplasms 23142026 MicroRNA-1 targets Slug and endows lung cancer A549 cells with epithelial and anti-tumorigenic properties -target gene hsa-mir-1-2 Lung Neoplasms 23142026 MicroRNA-1 targets Slug and endows lung cancer A549 cells with epithelial and anti-tumorigenic properties -target gene hsa-mir-152 Glioma 23142217 MiR-15b and miR-152 reduce glioma cell invasion and angiogenesis via NRP-2 and MMP-3 -target gene hsa-mir-15b Glioma 23142217 MiR-15b and miR-152 reduce glioma cell invasion and angiogenesis via NRP-2 and MMP-3 -target gene hsa-mir-24-1 Glioma 23142218 MiR-24 regulates the proliferation and invasion of glioma by ST7L via beta-catenin/Tcf-4 signaling -target gene hsa-mir-24-2 Glioma 23142218 MiR-24 regulates the proliferation and invasion of glioma by ST7L via beta-catenin/Tcf-4 signaling -target gene hsa-mir-517a "Carcinoma, Hepatocellular" 23142219 Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2 -target gene hsa-mir-517c "Carcinoma, Hepatocellular" 23142219 Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2 -target gene hsa-mir-27a Cardiomyopathy 23143062 MicroRNA-27a regulates cardiomyocytic apoptosis during cardioplegia-induced cardiac arrest by targeting interleukin 10-related pathways -target gene hsa-mir-135b Colorectal Carcinoma 23143558 Estradiol regulates miR-135b and mismatch repair gene expressions via estrogen receptor-beta in colorectal cells -target gene hsa-mir-146a Ischemia-Reperfusion Injury 23143987 MicroRNA-146a-mediated downregulation of IRAK1 protects mouse and human small intestine against ischemia/reperfusion injury. -target gene hsa-mir-149 Gastric Neoplasms 23144691 MicroRNA-149 inhibits proliferation and cell cycle progression through the targeting of ZBTB2 in human gastric cancer -target gene hsa-mir-550a-1 "Carcinoma, Hepatocellular" 23145039 MicroRNA-550a acts as a pro-metastatic gene and directly targets cytoplasmic polyadenylation element-binding protein 4 in hepatocellular carcinoma -target gene hsa-mir-550a-2 "Carcinoma, Hepatocellular" 23145039 MicroRNA-550a acts as a pro-metastatic gene and directly targets cytoplasmic polyadenylation element-binding protein 4 in hepatocellular carcinoma -target gene hsa-mir-550a-3 "Carcinoma, Hepatocellular" 23145039 MicroRNA-550a acts as a pro-metastatic gene and directly targets cytoplasmic polyadenylation element-binding protein 4 in hepatocellular carcinoma -target gene hsa-mir-100 Lung Neoplasms 23151088 MicroRNA-100 is a potential molecular marker of non-small cell lung cancer and functions as a tumor suppressor by targeting polo-like kinase 1 -target gene hsa-mir-137 Melanoma 23151846 miR-137 Inhibits the Invasion of Melanoma Cells through Downregulation of Multiple Oncogenic Target Genes -target gene hsa-mir-204 Gastric Neoplasms 23152059 miR-204 targets Bcl-2 expression and enhances responsiveness of gastric cancer -target gene hsa-mir-182 Human Immunodeficiency Virus Infection 23153509 Down-regulation of NAMPT expression by miR-182 is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation -target gene hsa-mir-1-1 Cardiomegaly 23156720 Effects of microRNA-1 on negatively regulating L-type calcium channel beta2 subunit gene expression during cardiac hypertrophy -target gene hsa-mir-1-2 Cardiomegaly 23156720 Effects of microRNA-1 on negatively regulating L-type calcium channel beta2 subunit gene expression during cardiac hypertrophy -target gene hsa-mir-200c Urinary Bladder Cancer 23159064 "Epithelial-mesenchymal transition, a novel target of sulforaphane via COX-2/MMP2,9/Snail, ZEB1 and miR-200c/ZEB1 pathways in human bladder cancer cells" -target gene hsa-mir-21 Wounds and Injuries [unspecific] 23159215 miR-21 regulates skin wound healing by targeting multiple aspects of the healing process -target gene hsa-mir-218-1 "Squamous Cell Carcinoma, Head and Neck" 23159910 Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion through targeting laminin-332 in head and neck squamous cell carcinoma -target gene hsa-mir-218-2 "Squamous Cell Carcinoma, Head and Neck" 23159910 Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion through targeting laminin-332 in head and neck squamous cell carcinoma -target gene hsa-mir-125b-1 Urinary Bladder Cancer 23160634 MiR-125b Inhibits Tumor Growth and Promotes Apoptosis of Cervical Cancer Cells by Targeting Phosphoinositide 3-Kinase Catalytic Subunit Delta -target gene hsa-mir-125b-2 Urinary Bladder Cancer 23160634 MiR-125b Inhibits Tumor Growth and Promotes Apoptosis of Cervical Cancer Cells by Targeting Phosphoinositide 3-Kinase Catalytic Subunit Delta -target gene hsa-mir-195 Osteosarcoma 23162665 microRNA-195 suppresses osteosarcoma cell invasion and migration in vitro by targeting FASN -target gene hsa-mir-133a-1 Cardiomegaly 23166348 Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy -target gene hsa-mir-133a-2 Cardiomegaly 23166348 Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy -target gene hsa-mir-361 "Squamous Cell Carcinoma, Skin or Unspecific" 23166713 The expression levels of microRNA-361-5p and its target VEGFA are inversely correlated in human cutaneous squamous cell carcinoma -target gene hsa-mir-222 Colorectal Carcinoma 23173124 "On the other hand, miR-222 targeting ADAM-17, a disintegrin and metalloproteinase, and miR-328 interacting with ABCG2, an ABC transporter, may overcome drug resistance of cancer cells." -target gene hsa-mir-29a Colorectal Carcinoma 23173124 "microRNA levels may serve as a predictive CRC marker, which was confirmed by the serum level of miR-29a targeting KLF4, a marker of cell stemness, and the plasma level of miR-221 down-regulating c-Kit, Stat5A and ETS1, which are signal transducers and transcription factor, respectively" -target gene hsa-mir-21 Colorectal Carcinoma 23174819 MiR-21 regulates biological behavior through the PTEN/PI-3 K/Akt signaling pathway in human colorectal cancer cells -target gene hsa-mir-16-1 Glioma 23175429 Zyxin may be one of putative target genes of miR-16-1 -target gene hsa-mir-16-2 Glioma 23175429 Zyxin may be one of putative target genes of miR-16-1 -target gene hsa-mir-657 "Carcinoma, Hepatocellular" 23175432 MiR-657 promotes tumorigenesis in hepatocellular carcinoma by targeting transducin-like enhancer protein 1 through NF-kB pathways -target gene hsa-mir-15a Neuroblastoma 23176145 MicroRNA-15a promotes neuroblastoma migration by targeting reversion-inducing cysteine-rich protein with Kazal motifs (RECK) and regulating matrix metalloproteinase-9 expression -target gene hsa-mir-135a-1 "Carcinoma, Renal Cell" 23176581 Tumor-suppressive microRNA-135a inhibits cancer cell proliferation by targeting the c-MYC oncogene in renal cell carcinoma -target gene hsa-mir-135a-2 "Carcinoma, Renal Cell" 23176581 Tumor-suppressive microRNA-135a inhibits cancer cell proliferation by targeting the c-MYC oncogene in renal cell carcinoma -target gene hsa-mir-21 Pancreatic Neoplasms 23177026 "The serum miR-21 level serves as a predictor for the chemosensitivity of advanced pancreatic cancer, and miR-21 expression confers chemoresistance by targeting FasL" -target gene hsa-mir-137 Lung Neoplasms 23178712 miR-137 inhibits the proliferation of lung cancer cells by targeting Cdc42 and Cdk6 -target gene hsa-mir-101-1 Neoplasms [unspecific] 23178713 MicroRNA-101 suppresses SOX9-dependent tumorigenicity and promotes favorable prognosis of human hepatocellular carcinoma -target gene hsa-mir-101-2 Neoplasms [unspecific] 23178713 MicroRNA-101 suppresses SOX9-dependent tumorigenicity and promotes favorable prognosis of human hepatocellular carcinoma -target gene hsa-mir-137 Neoplasms [unspecific] 23178914 miR-137 restoration sensitizes multidrug-resistant MCF-7/ADM cells to anticancer agents by targeting YB-1 -target gene hsa-mir-1290 Breast Neoplasms 23183268 MiR-1290 and its potential targets are associated with characteristics of estrogen receptor alpha-positive breast cancer -target gene hsa-mir-133a-1 Liver Cirrhosis 23183523 miR-133a mediates TGF-beta-dependent de-repression of collagen-synthesis in hepatic stellate cells during liver fibrosis -target gene hsa-mir-133a-2 Liver Cirrhosis 23183523 miR-133a mediates TGF-beta-dependent de-repression of collagen-synthesis in hepatic stellate cells during liver fibrosis -target gene hsa-mir-302a Urinary Bladder Cancer 23185040 The microRNA-302-367 cluster suppresses the proliferation of cervical carcinoma cells through the novel target AKT1 -target gene hsa-mir-367 Urinary Bladder Cancer 23185040 The microRNA-302-367 cluster suppresses the proliferation of cervical carcinoma cells through the novel target AKT1 -target gene hsa-mir-214 Glioma 23187003 microRNA-214-mediated UBC9 expression in glioma -target gene hsa-mir-320a Prostate Neoplasms 23188675 MicroRNA-320 suppresses the stem cell-like characteristics of prostate cancer cells by downregulating the Wnt/beta-catenin signaling pathway -target gene hsa-mir-98 Prostate Neoplasms 23188821 Identification of microRNA-98 as a Therapeutic Target Inhibiting Prostate Cancer Growth and a Biomarker Induced by Vitamin D -target gene hsa-mir-23b "Carcinoma, Renal Cell" 23189187 Inhibition of PTEN gene expression by oncogenic miR-23b-3p in renal cancer -target gene hsa-mir-17 Pancreatic Neoplasms 23194063 "The mechanism of curcumin-/RL197-induced repression of Sp transcription factors was ROS-dependent and due to induction of the Sp repressors ZBTB10 and ZBTB4 and downregulation of microRNAs (miR)-27a, miR-20a and miR-17-5p that regulate these repressors." -target gene hsa-mir-20a Pancreatic Neoplasms 23194063 "The mechanism of curcumin-/RL197-induced repression of Sp transcription factors was ROS-dependent and due to induction of the Sp repressors ZBTB10 and ZBTB4 and downregulation of microRNAs (miR)-27a, miR-20a and miR-17-5p that regulate these repressors." -target gene hsa-mir-27a Pancreatic Neoplasms 23194063 "The mechanism of curcumin-/RL197-induced repression of Sp transcription factors was ROS-dependent and due to induction of the Sp repressors ZBTB10 and ZBTB4 and downregulation of microRNAs (miR)-27a, miR-20a and miR-17-5p that regulate these repressors." -target gene hsa-mir-320a Myasthenia Gravis 23196978 MiR-320a is Downregulated in Patients with Myasthenia Gravis and Modulates Inflammatory Cytokines Production by Targeting Mitogen-activated Protein Kinase 1 -target gene hsa-mir-200b Endometrial Neoplasms 23205572 MicroRNA-200b Is Overexpressed in Endometrial Adenocarcinomas and Enhances MMP2 Activity by Downregulating TIMP2 in Human Endometrial Cancer Cell Line HEC-1A Cells -target gene hsa-mir-133a-1 Urinary Bladder Cancer 23206218 "MicroRNA-133 inhibits cell proliferation, migration and invasion by targeting epidermal growth factor receptor and its downstream effector proteins in bladder cancer" -target gene hsa-mir-133a-2 Urinary Bladder Cancer 23206218 "MicroRNA-133 inhibits cell proliferation, migration and invasion by targeting epidermal growth factor receptor and its downstream effector proteins in bladder cancer" -target gene hsa-mir-133b Urinary Bladder Cancer 23206218 "MicroRNA-133 inhibits cell proliferation, migration and invasion by targeting epidermal growth factor receptor and its downstream effector proteins in bladder cancer" -target gene hsa-mir-375 Lung Neoplasms 23206448 miR-375 is a novel prognostic indicator in NSCLC and might be a potential target for diagnosis and gene therapy -target gene hsa-mir-7-1 Melanoma 23206698 "miR-7-5p may represent a novel tumor suppressor miRNA in melanoma, acting at least in part via its inhibition of IRS-2 expression and oncogenic Akt signaling" -target gene hsa-mir-7-2 Melanoma 23206698 "miR-7-5p may represent a novel tumor suppressor miRNA in melanoma, acting at least in part via its inhibition of IRS-2 expression and oncogenic Akt signaling" -target gene hsa-mir-7-3 Melanoma 23206698 "miR-7-5p may represent a novel tumor suppressor miRNA in melanoma, acting at least in part via its inhibition of IRS-2 expression and oncogenic Akt signaling" -target gene hsa-mir-10b Endometriosis 23206733 Targeting of syndecan-1 by micro-ribonucleic acid miR-10b modulates invasiveness of endometriotic cells via dysregulation of the proteolytic milieu and interleukin-6 secretion -target gene hsa-mir-21 "Carcinoma, Renal Cell" 23206776 miR-21 Downregulated TCF21 to Inhibit KISS1 in Renal Cancer -target gene hsa-mir-223 Osteosarcoma 23208072 Heat Shock Protein 90B1 Plays an Oncogenic Role and is a Target of microRNA-223 in Human Osteosarcoma -target gene hsa-mir-7-1 Colorectal Carcinoma 23208495 microRNA-7 is a novel inhibitor of YY1 contributing to colorectal tumorigenesis -target gene hsa-mir-7-2 Colorectal Carcinoma 23208495 microRNA-7 is a novel inhibitor of YY1 contributing to colorectal tumorigenesis -target gene hsa-mir-7-3 Colorectal Carcinoma 23208495 microRNA-7 is a novel inhibitor of YY1 contributing to colorectal tumorigenesis -target gene hsa-mir-200a Breast Neoplasms 23209748 miR-200c Sensitizes Breast Cancer Cells to Doxorubicin Treatment by Decreasing TrkB and Bmi1 Expression -target gene hsa-mir-200b Breast Neoplasms 23209748 miR-200c Sensitizes Breast Cancer Cells to Doxorubicin Treatment by Decreasing TrkB and Bmi1 Expression -target gene hsa-mir-200c Breast Neoplasms 23209748 miR-200c Sensitizes Breast Cancer Cells to Doxorubicin Treatment by Decreasing TrkB and Bmi1 Expression -target gene hsa-mir-98 Neoplasms [unspecific] 23211491 MicroRNA miR-98 inhibits tumor angiogenesis and invasion by targeting activin receptor-like kinase-4 and matrix metalloproteinase-11 -target gene hsa-mir-150 Cardiomegaly 23211718 miR-150 regulates high glucose-induced cardiomyocyte hypertrophy by targeting the transcriptional co-activator p300 -target gene hsa-mir-205 "Carcinoma, Oral" 23212344 "MicroRNA-205 directly regulates the tumor suppressor, interleukin-24, in human KB oral cancer cells" -target gene hsa-mir-218-1 Medulloblastoma 23212916 MicroRNA 218 acts as a tumor suppressor by targeting multiple cancer phenotype associated genes in medulloblastoma -target gene hsa-mir-218-2 Medulloblastoma 23212916 MicroRNA 218 acts as a tumor suppressor by targeting multiple cancer phenotype associated genes in medulloblastoma -target gene hsa-mir-145 Neuroblastoma 23222716 "MicroRNA-145 inhibits the growth, invasion, metastasis and angiogenesis of neuroblastoma cells through targeting hypoxia-inducible factor 2 alpha" -target gene hsa-mir-30c-1 Breast Neoplasms 23224145 MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion. -target gene hsa-mir-30c-2 Breast Neoplasms 23224145 MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion. -target gene hsa-mir-16-1 "Carcinoma, Hepatocellular" 23226427 Cyclooxygenase-2 Is a Target of MicroRNA-16 in Human Hepatoma Cells -target gene hsa-mir-16-2 "Carcinoma, Hepatocellular" 23226427 Cyclooxygenase-2 Is a Target of MicroRNA-16 in Human Hepatoma Cells -target gene hsa-mir-182 Urinary Bladder Cancer 23226455 Oncogenic miRNA-182-5p Targets Smad4 and RECK in Human Bladder Cancer -target gene hsa-mir-21 "Carcinoma, Endometrioid Endometrial" 23226804 microRNA-21 overexpression contributes to cell proliferation by targeting PTEN in endometrioid endometrial cancer -target gene hsa-mir-383 Medulloblastoma 23227829 MiR-383 is Downregulated in Medulloblastoma and Targets Peroxiredoxin 3 (PRDX3) -target gene hsa-mir-125b-1 "Carcinoma, Oral" 23230394 "Subsite-based alterations in miR-21, miR-125b, and miR-203 in squamous cell carcinoma of the oral cavity and correlation to important target proteins" -target gene hsa-mir-125b-2 "Carcinoma, Oral" 23230394 "Subsite-based alterations in miR-21, miR-125b, and miR-203 in squamous cell carcinoma of the oral cavity and correlation to important target proteins" -target gene hsa-mir-203 "Carcinoma, Oral" 23230394 "Subsite-based alterations in miR-21, miR-125b, and miR-203 in squamous cell carcinoma of the oral cavity and correlation to important target proteins" -target gene hsa-mir-21 "Carcinoma, Oral" 23230394 "Subsite-based alterations in miR-21, miR-125b, and miR-203 in squamous cell carcinoma of the oral cavity and correlation to important target proteins" -target gene hsa-mir-370 "Carcinoma, Oral" 23231387 miR-370 modulates insulin receptor substrate-1 expression and inhibits the tumor phenotypes of oral carcinoma -target gene hsa-mir-335 Lung Neoplasms 23232114 Genetic variation in a miR-335 binding site in BIRC5 alters susceptibility to lung cancer in Chinese Han populations -target gene hsa-mir-145 Gastric Neoplasms 23233482 "microRNA-145 targets v-ets erythroblastosis virus E26 oncogene homolog 1 to suppress the invasion, metastasis and angiogenesis of gastric cancer cells" -target gene hsa-mir-148b Breast Neoplasms 23233531 "miR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS,and CSF1" -target gene hsa-mir-31 Psoriasis 23233723 MicroRNA-31 Is Overexpressed in Psoriasis and Modulates Inflammatory Cytokine and Chemokine Production in Keratinocytes via Targeting Serine/Threonine Kinase 40 -target gene hsa-mir-596 "Carcinoma, Oral" 23233740 Potential of tumor-suppressive miR-596 targeting LGALS3BP as a therapeutic agent in oral cancer -target gene hsa-mir-27a "Leukemia, Myeloid, Acute" 23236401 MiR-27a Functions as a Tumor Suppressor in Acute Leukemia by Regulating 14-3-3 -target gene hsa-mir-372 Gastric Neoplasms 23242208 microRNA-372 maintains oncogene characteristics by targeting TNFAIP1 and affects NFkB signaling in human gastric carcinoma cells -target gene hsa-mir-218-1 Glioma 23243056 MiR-218 sensitizes glioma cells to apoptosis and inhibits tumorigenicity by regulating ECOP-mediated suppression of NF-kB activity -target gene hsa-mir-218-2 Glioma 23243056 MiR-218 sensitizes glioma cells to apoptosis and inhibits tumorigenicity by regulating ECOP-mediated suppression of NF-kB activity -target gene hsa-mir-29a Melanoma 23245396 Interferon-gamma-induced activation of Signal Transducer and Activator of Transcription 1 (STAT1) up-regulates the tumor suppressing microRNA-29 family in melanoma cells -target gene hsa-mir-29b-1 Melanoma 23245396 Interferon-gamma-induced activation of Signal Transducer and Activator of Transcription 1 (STAT1) up-regulates the tumor suppressing microRNA-29 family in melanoma cells -target gene hsa-mir-29b-2 Melanoma 23245396 Interferon-gamma-induced activation of Signal Transducer and Activator of Transcription 1 (STAT1) up-regulates the tumor suppressing microRNA-29 family in melanoma cells -target gene hsa-mir-17 Myelodysplastic Syndromes 23246221 "Expression analysis of mir-17-5p, mir-20a and let-7a microRNAs and their target proteins in CD34+ bone marrow cells of patients with myelodysplastic syndromes" -target gene hsa-mir-20a Myelodysplastic Syndromes 23246221 "Expression analysis of mir-17-5p, mir-20a and let-7a microRNAs and their target proteins in CD34+ bone marrow cells of patients with myelodysplastic syndromes" -target gene hsa-mir-363 Head And Neck Neoplasms 23246488 Dysregulated miR-363 affects head and neck cancer invasion and metastasis by targeting podoplanin -target gene hsa-mir-18a Glioblastoma 23249750 Targeting of TGFbeta signature and its essential component CTGF by miR-18 correlates with improved survival in glioblastoma -target gene hsa-mir-143 Glioma 23250070 Rapamycin inhibits human glioma cell proliferation through down-regulating mammalian target of rapamycin pathway and up-regulating microRNA-143 -target gene hsa-mir-17 Colorectal Carcinoma 23250421 Elevated oncofoetal miR-17-5p expression regulates colorectal cancer progression by repressing its target gene P130 -target gene hsa-mir-124-1 Breast Neoplasms 23250910 MiR-124 targets Slug to regulate epithelial-mesenchymal transition and metastasis of breast cancer -target gene hsa-mir-124-2 Breast Neoplasms 23250910 MiR-124 targets Slug to regulate epithelial-mesenchymal transition and metastasis of breast cancer -target gene hsa-mir-124-3 Breast Neoplasms 23250910 MiR-124 targets Slug to regulate epithelial-mesenchymal transition and metastasis of breast cancer -target gene hsa-mir-145 Choriocarcinoma 23251245 Cell proliferation and invasion ability of human choriocarcinoma cells lessened due to inhibition of Sox2 expression by microRNA-145 -target gene hsa-mir-137 Oligodendroglioma 23252729 "MIR-137 Suppresses Growth and Invasion, is Downregulated in Oligodendroglial Tumors and Targets CSE1L" -target gene hsa-mir-21 Cholangiocarcinoma 23254774 "These data indicated that TPM1 is downregulated in HuCCT1 cells and that the Ras signaling pathway as well as DNA methylation, histone deacetylation and miR-21 upregulation play important roles in the suppression of TPM1 expression in HuCCT1 cells. Thus, compounds that inhibit genetic and epigenetic mechanisms may be promising agents in treating cholangiocarcinoma." -target gene hsa-mir-24-1 Glioma 23254855 miR-24-3p and miR-27a-3p promote cell proliferation in glioma cells via cooperative regulation of MXI1 -target gene hsa-mir-24-2 Glioma 23254855 miR-24-3p and miR-27a-3p promote cell proliferation in glioma cells via cooperative regulation of MXI1 -target gene hsa-mir-27a Glioma 23254855 miR-24-3p and miR-27a-3p promote cell proliferation in glioma cells via cooperative regulation of MXI1 -target gene hsa-mir-218-1 Colon Neoplasms 23255074 MicroRNA-218 inhibits cell cycle progression and promotes apoptosis in colon cancer by downregulating oncogene BMI-1 -target gene hsa-mir-218-2 Colon Neoplasms 23255074 MicroRNA-218 inhibits cell cycle progression and promotes apoptosis in colon cancer by downregulating oncogene BMI-1 -target gene hsa-mir-491 Acute Cerebral Infarction 23257658 A functional polymorphism at miR-491-5p binding site in the 3'-UTR of MMP-9 gene confers increased risk for atherosclerotic cerebral infarction in a Chinese population -target gene hsa-mir-31 Colon Neoplasms 23258531 miR-31 acts as an oncogene in colon cancer and identified RhoBTB1 as a new target of miR-31 further study demonstrated that miR-31 contributed to the development of colon cancer at least partly by targeting RhoBTB1 -target gene hsa-mir-122 Atherosclerosis 23260873 "Several miRNAs have been described to finely regulate lipid metabolism and the progression and regression of atherosclerosis including, miR-33, miR-122." -target gene hsa-mir-33 Atherosclerosis 23260873 "Several miRNAs have been described to finely regulate lipid metabolism and the progression and regression of atherosclerosis including, miR-33, miR-122." -target gene hsa-mir-424 Hypertension 23263626 An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension -target gene hsa-mir-503 Hypertension 23263626 An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension -target gene hsa-mir-34a Gastric Neoplasms 23264087 Expression and regulatory function of miRNA-34a in targeting survivin in gastric cancer cells -target gene hsa-mir-501 Hepatitis B Virus Infection 23266610 MicroRNA-501 promotes HBV replication by targeting HBXIP -target gene hsa-let-7d Ovarian Neoplasms 23268403 Construction of let-7d expression vector and its inhibitory effect on HMGA2 and ras expression in human ovarian cancer cells in vitro -target gene hsa-mir-100 Urinary Bladder Cancer 23270926 MicroRNA-100 inhibits human bladder urothelial carcinogenesis by directly targeting mTOR -target gene hsa-mir-21 "Lymphoma, Large B-Cell, Diffuse" 23275230 MicroRNA-21 regulates the sensitivity of diffuse large B-cell lymphoma cells to the CHOP chemotherapy regimen -target gene hsa-mir-362 Colorectal Carcinoma 23280316 "MiRNA-362-3p induces cell cycle arrest through targeting of E2F1, USF2 and PTPN1 and is associated with recurrence of colorectal cancer" -target gene hsa-mir-182 Urinary Bladder Cancer 23284967 Synthetic miRNA-Mowers Targeting miR-183-96-182 Cluster or miR-210 Inhibit Growth and Migration and Induce Apoptosis in Bladder Cancer Cells -target gene hsa-mir-183 Urinary Bladder Cancer 23284967 Synthetic miRNA-Mowers Targeting miR-183-96-182 Cluster or miR-210 Inhibit Growth and Migration and Induce Apoptosis in Bladder Cancer Cells -target gene hsa-mir-210 Urinary Bladder Cancer 23284967 Synthetic miRNA-Mowers Targeting miR-183-96-182 Cluster or miR-210 Inhibit Growth and Migration and Induce Apoptosis in Bladder Cancer Cells -target gene hsa-mir-96 Urinary Bladder Cancer 23284967 Synthetic miRNA-Mowers Targeting miR-183-96-182 Cluster or miR-210 Inhibit Growth and Migration and Induce Apoptosis in Bladder Cancer Cells -target gene hsa-mir-126 "Colitis, Ulcerative" 23285182 Up-Regulation of microRNA-126 May Contribute to Pathogenesis of Ulcerative Colitis via Regulating NF-kappaB Inhibitor I§Ø¨mB§Ø©ã -target gene hsa-mir-9-1 Nasopharyngeal Neoplasms 23291181 miR-9 modulates the expression of interferon-regulated genes and MHC class I molecules in human nasopharyngeal carcinoma cells -target gene hsa-mir-9-2 Nasopharyngeal Neoplasms 23291181 miR-9 modulates the expression of interferon-regulated genes and MHC class I molecules in human nasopharyngeal carcinoma cells -target gene hsa-mir-100 Esophageal Neoplasms 23292834 MicroRNA-99a/100 promotes apoptosis by targeting mTOR in human esophageal squamous cell carcinoma -target gene hsa-mir-99a Esophageal Neoplasms 23292834 MicroRNA-99a/100 promotes apoptosis by targeting mTOR in human esophageal squamous cell carcinoma -target gene hsa-mir-196b Endometriosis 23293219 "miR-196b targets c-myc and Bcl-2 expression, inhibits proliferation and induces apoptosis in endometriotic stromal cells" -target gene hsa-mir-133b Gastric Neoplasms 23296701 miR-133b acts as a tumor suppressor and negatively regulates FGFR1 in gastric cancer -target gene hsa-mir-199b Breast Neoplasms 23296799 MiR-199b-5p targets HER2 in breast cancer cells -target gene hsa-mir-182 Ovarian Neoplasms 23296900 "MicroRNA-182 promotes cell growth, invasion and chemoresistance by targeting programmed cell death 4 (PDCD4) in human ovarian carcinomas" -target gene hsa-mir-149 Glioma 23298478 MicroRNA-149 inhibits proliferation and invasion of glioma cells via blockade of AKT1 signaling -target gene hsa-mir-107 Glioma 23299462 MicroRNA-107 inhibits glioma cell migration and invasion by modulating Notch2 expression -target gene hsa-mir-150 Esophageal Neoplasms 23301507 MiR-150 regulates the EMT-inducer ZEB1 in esophageal squamous cell carcinoma.Wound healing assays of premiR-150-treated esophageal squamous cell carcinoma TE-8 cells -target gene hsa-mir-16-1 Ovarian Neoplasms 23302126 "MicroRNA-16 regulates the proliferation, invasion and apoptosis of ovarian epithelial carcinoma cells in vitro" -target gene hsa-mir-16-2 Ovarian Neoplasms 23302126 "MicroRNA-16 regulates the proliferation, invasion and apoptosis of ovarian epithelial carcinoma cells in vitro" -target gene hsa-mir-34b Pancreatic Neoplasms 23305226 MicroRNA-34b inhibits pancreatic cancer metastasis through repressing Smad3 -target gene hsa-mir-636 "Carcinoma, Hepatocellular" 23306701 "ANT2 suppression by shRNA restores miR-636 expression, thereby downregulating Ras and inhibiting tumorigenesis of hepatocellular carcinoma" -target gene hsa-mir-145 Endometriosis 23312222 "MicroRNA miR-145 inhibits proliferation, invasiveness, and stem cell phenotype of an in vitro endometriosis model by targeting multiple cytoskeletal elements and pluripotency factors" -target gene hsa-mir-34a Osteosarcoma 23314380 miR-34a inhibits the metastasis of osteosarcoma cells by repressing the expression of CD44. -target gene hsa-mir-384 Myocardial Ischemic-Reperfusion Injury 23315007 "MicroRNA-384-5p regulates ischemia-induced cardioprotection by targeting phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta (PI3Kp110§Ø©¤)" -target gene hsa-mir-152 Ovarian Neoplasms 23318422 MiR-152 and miR-185 co-contribute to ovarian cancer cells cisplatin sensitivity by targeting DNMT1 directly: a novel epigenetic therapy independent of decitabine -target gene hsa-mir-185 Ovarian Neoplasms 23318422 MiR-152 and miR-185 co-contribute to ovarian cancer cells cisplatin sensitivity by targeting DNMT1 directly: a novel epigenetic therapy independent of decitabine -target gene hsa-mir-138 "Squamous Cell Carcinoma, Esophageal" 23319823 Downregulation of miR-138 sustains NF-¦ÊB activation and promotes lipid raft formation in esophageal squamous cell carcinoma. -target gene hsa-mir-18a Gastric Neoplasms 23322197 MicroRNA-18a modulates STAT3 activity through negative regulation of PIAS3 during gastric adenocarcinogenesis -target gene hsa-mir-31 Colorectal Carcinoma 23322774 MicroRNA-31 activates the Ras pathway and functions as an oncogenic microRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1(RASA1). -target gene hsa-mir-30a "Cardiomyopathy, Hypertrophic" 23326547 miR-30a induced alterations in beclin-1 gene expression and autophagy in cardiomyocytes. -target gene hsa-mir-122 Infertility 23327642 MicroRNA-122 influences the development of sperm abnormalities from human induced pluripotent stem cells by regulating TNP2 expression. -target gene hsa-mir-182 Prostate Neoplasms 23329838 MicroRNA-182 and microRNA-200a control G-protein subunit alpha-13 (GNA13) expression and cell invasion synergistically in prostate cancer cells. -target gene hsa-mir-200a Prostate Neoplasms 23329838 MicroRNA-182 and microRNA-200a control G-protein subunit alpha-13 (GNA13) expression and cell invasion synergistically in prostate cancer cells. -target gene hsa-mir-221 Coronary Artery Disease 23333386 "Overall, these findings demonstrate that miR-221 affects the MEK/ERK pathway by targeting PAK1 to inhibit the proliferation of EPCs." -target gene hsa-mir-182 Breast Neoplasms 23333633 Up-regulation of miR-182 by beta-catenin in breast cancer increases tumorigenicity and invasiveness by targeting the matrix metalloproteinase inhibitor RECK -target gene hsa-mir-193b Neoplasms [unspecific] 23335975 MicroRNA-193b enhances tumor progression via down regulation of neurofibromin 1 -target gene hsa-mir-330 Colorectal Carcinoma 23337504 miR-330 regulates the proliferation of colorectal cancer cells by targeting Cdc42 -target gene hsa-mir-301a Gastric Neoplasms 23338485 Overexpressed miR-301a promotes cell proliferation and invasion by targeting RUNX3 in gastric cancer -target gene hsa-mir-200a Breast Neoplasms 23340296 MicroRNA-200a Promotes Anoikis Resistance and Metastasis by Targeting YAP1 in Human Breast Cancer -target gene hsa-let-7a Head And Neck Neoplasms 23340306 "miR-21, miR-31, miR-504 and miR-10b are important oncogenic miRNAs that are involved in HNSCC and target tumour suppressor genes. The tumour suppressor roles of the let-7 family, the miR-99 family, miR-107, miR-133a, miR-137, miR-138 and miR-375 with respect to their targeting of oncogenes are unequivocal and have been confirmed by many studies." -target gene hsa-let-7b Head And Neck Neoplasms 23340306 "miR-21, miR-31, miR-504 and miR-10b are important oncogenic miRNAs that are involved in HNSCC and target tumour suppressor genes. The tumour suppressor roles of the let-7 family, the miR-99 family, miR-107, miR-133a, miR-137, miR-138 and miR-375 with respect to their targeting of oncogenes are unequivocal and have been confirmed by many studies." -target gene hsa-let-7c Head And Neck Neoplasms 23340306 "miR-21, miR-31, miR-504 and miR-10b are important oncogenic miRNAs that are involved in HNSCC and target tumour suppressor genes. The tumour suppressor roles of the let-7 family, the miR-99 family, miR-107, miR-133a, miR-137, miR-138 and miR-375 with respect to their targeting of oncogenes are unequivocal and have been confirmed by many studies." -target gene hsa-let-7d Head And Neck Neoplasms 23340306 "miR-21, miR-31, miR-504 and miR-10b are important oncogenic miRNAs that are involved in HNSCC and target tumour suppressor genes. The tumour suppressor roles of the let-7 family, the miR-99 family, miR-107, miR-133a, miR-137, miR-138 and miR-375 with respect to their targeting of oncogenes are unequivocal and have been confirmed by many studies." -target gene hsa-let-7e Head And Neck Neoplasms 23340306 "miR-21, miR-31, miR-504 and miR-10b are important oncogenic miRNAs that are involved in HNSCC and target tumour suppressor genes. The tumour suppressor roles of the let-7 family, the miR-99 family, miR-107, miR-133a, miR-137, miR-138 and miR-375 with respect to their targeting of oncogenes are unequivocal and have been confirmed by many studies." -target gene hsa-let-7f Head And Neck Neoplasms 23340306 "miR-21, miR-31, miR-504 and miR-10b are important oncogenic miRNAs that are involved in HNSCC and target tumour suppressor genes. The tumour suppressor roles of the let-7 family, the miR-99 family, miR-107, miR-133a, miR-137, miR-138 and miR-375 with respect to their targeting of oncogenes are unequivocal and have been confirmed by many studies." -target gene hsa-let-7g Head And Neck Neoplasms 23340306 "miR-21, miR-31, miR-504 and miR-10b are important oncogenic miRNAs that are involved in HNSCC and target tumour suppressor genes. The tumour suppressor roles of the let-7 family, the miR-99 family, miR-107, miR-133a, miR-137, miR-138 and miR-375 with respect to their targeting of oncogenes are unequivocal and have been confirmed by many studies." -target gene hsa-let-7i Head And Neck Neoplasms 23340306 "miR-21, miR-31, miR-504 and miR-10b are important oncogenic miRNAs that are involved in HNSCC and target tumour suppressor genes. The tumour suppressor roles of the let-7 family, the miR-99 family, miR-107, miR-133a, miR-137, miR-138 and miR-375 with respect to their targeting of oncogenes are unequivocal and have been confirmed by many studies." -target gene hsa-mir-10b Head And Neck Neoplasms 23340306 "miR-21, miR-31, miR-504 and miR-10b are important oncogenic miRNAs that are involved in HNSCC and target tumour suppressor genes. The tumour suppressor roles of the let-7 family, the miR-99 family, miR-107, miR-133a, miR-137, miR-138 and miR-375 with respect to their targeting of oncogenes are unequivocal and have been confirmed by many studies." -target gene hsa-mir-21 Head And Neck Neoplasms 23340306 "miR-21, miR-31, miR-504 and miR-10b are important oncogenic miRNAs that are involved in HNSCC and target tumour suppressor genes. The tumour suppressor roles of the let-7 family, the miR-99 family, miR-107, miR-133a, miR-137, miR-138 and miR-375 with respect to their targeting of oncogenes are unequivocal and have been confirmed by many studies." -target gene hsa-mir-31 Head And Neck Neoplasms 23340306 "miR-21, miR-31, miR-504 and miR-10b are important oncogenic miRNAs that are involved in HNSCC and target tumour suppressor genes. The tumour suppressor roles of the let-7 family, the miR-99 family, miR-107, miR-133a, miR-137, miR-138 and miR-375 with respect to their targeting of oncogenes are unequivocal and have been confirmed by many studies." -target gene hsa-mir-504 Head And Neck Neoplasms 23340306 "miR-21, miR-31, miR-504 and miR-10b are important oncogenic miRNAs that are involved in HNSCC and target tumour suppressor genes. The tumour suppressor roles of the let-7 family, the miR-99 family, miR-107, miR-133a, miR-137, miR-138 and miR-375 with respect to their targeting of oncogenes are unequivocal and have been confirmed by many studies." -target gene hsa-mir-30c-1 Breast Neoplasms 23340433 MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11 -target gene hsa-mir-30c-2 Breast Neoplasms 23340433 MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11 -target gene hsa-mir-138-1 Lung Neoplasms 23343715 MiR-138 Inhibits Tumor Growth Through Repression of EZH2 in Non-Small Cell Lung Cancer -target gene hsa-mir-138-2 Lung Neoplasms 23343715 MiR-138 Inhibits Tumor Growth Through Repression of EZH2 in Non-Small Cell Lung Cancer -target gene hsa-mir-206 Gastric Neoplasms 23348698 MiR-206 inhibits gastric cancer proliferation in part by repressing CyclinD2 -target gene hsa-mir-30a Glioma 23348703 PRDM1 is directly targeted by miR-30a-5p and modulates the Wnt/beta-catenin pathway in a Dkk1-dependent manner during glioma growth -target gene hsa-mir-34a Lung Neoplasms 23349340 "Ectopic expression of miR-34a enhances radiosensitivity of non-small cell lung cancer cells, partly by suppressing the LyGDI signaling pathway" -target gene hsa-mir-22 Huntington Disease 23349832 MicroRNA-22 (miR-22) Overexpression Is Neuroprotective via General Anti-Apoptotic Effects and May also Target Specific Huntington's Disease-Related Mechanisms -target gene hsa-mir-296 Gastric Neoplasms 23353818 MicroRNA-296-5p increases proliferation in gastric cancer through repression of Caudal-related homeobox 1 -target gene hsa-mir-155 Breast Neoplasms 23353819 Upregulation of miRNA-155 promotes tumour angiogenesis by targeting VHL and is associated with poor prognosis and triple-negative breast cance -target gene hsa-mir-145 Prostate Neoplasms 23355420 HEF1 promotes epithelial mesenchymal transition and bone invasion in prostate cancer under the regulation of microRNA-145 -target gene hsa-mir-21 Pancreatic Neoplasms 23359184 Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR-21 regulation of BCL-2 expression -target gene hsa-mir-24 Breast Neoplasms 23359482 "Downregulation of HR genes correlated with increased levels of their predicted microRNAs (miRNAs), miR-183 (predicted target RAD50) and miR-24 (predicted target BRCA1), suggesting that PE may regulate miRNAs involved in DNA repair processes." -target gene hsa-mir-199a-1 Cardiomyopathy 23360823 TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy -target gene hsa-mir-199a-2 Cardiomyopathy 23360823 TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy -target gene hsa-mir-199b Cardiomyopathy 23360823 TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy -target gene hsa-mir-214 Cardiomyopathy 23360823 TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy -target gene hsa-mir-34a Neoplasms [unspecific] 23361983 Modeling miRNA Regulation in Cancer Signaling Systems: miR-34a Regulation of the p53/Sirt1 Signaling Module -target gene hsa-mir-31 Breast Neoplasms 23364795 microRNA-31 sensitizes human breast cells to apoptosis by direct targeting of protein kinase C epsilon -target gene hsa-mir-100 Pancreatic Neoplasms 23373509 MicroRNA-100 regulates IGF1-receptor expression in metastatic pancreatic cancer cells -target gene hsa-mir-122 Liver Neoplasms 23373973 Effect of miR-122 and its target gene cationic amino acid transporter 1 on colorectal liver metastasis -target gene hsa-mir-26b Breast Neoplasms 23374284 MiRNA-26b inhibits proliferation by targeting PTGS2 in breast cancer -target gene hsa-mir-106b Glioma 23377830 miR-106b facilitates glioma cell growth by promoting cell cycle progression through the negative regulation of RBL2 -target gene hsa-mir-16-1 Colorectal Carcinoma 23380758 microRNA-16 represses colorectal cancer cell growth in vitro by regulating the p53/survivin signaling pathway -target gene hsa-mir-16-2 Colorectal Carcinoma 23380758 microRNA-16 represses colorectal cancer cell growth in vitro by regulating the p53/survivin signaling pathway -target gene hsa-mir-200a Gastric Neoplasms 23381389 Downregulated microRNA-200a promotes EMT and tumor growth through the wnt/beta-catenin pathway by targeting the E-cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma -target gene hsa-mir-195 Glioma 23383003 MicroRNA-195 Inhibits the Proliferation of Human Glioma Cells by Directly Targeting Cyclin D1 and Cyclin E1 -target gene hsa-mir-30a Glioma 23383034 MiR-30a-5p Antisense Oligonucleotide Suppresses Glioma Cell Growth by Targeting SEPT7 -target gene hsa-mir-182 Prostate Neoplasms 23383207 "MicroRNA-182-5p Promotes Cell Invasion and Proliferation by Down Regulating FOXF2, RECK and MTSS1 Genes in Human Prostate Cancer" -target gene hsa-mir-9-1 Gastric Neoplasms 23383271 "microRNA-9 Suppresses the Proliferation, Invasion and Metastasis of Gastric Cancer Cells through Targeting Cyclin D1 and Ets1" -target gene hsa-mir-9-2 Gastric Neoplasms 23383271 "microRNA-9 Suppresses the Proliferation, Invasion and Metastasis of Gastric Cancer Cells through Targeting Cyclin D1 and Ets1" -target gene hsa-mir-9-3 Gastric Neoplasms 23383271 "microRNA-9 Suppresses the Proliferation, Invasion and Metastasis of Gastric Cancer Cells through Targeting Cyclin D1 and Ets1" -target gene hsa-mir-143 Prostate Neoplasms 23383988 Up-regulated microRNA-143 in cancer stem cells differentiation promotes prostate cancer cells metastasis by modulating FNDC3B expression -target gene hsa-mir-7-1 Breast Neoplasms 23384942 miR-7 Suppresses Brain Metastasis of Breast Cancer Stem-Like Cells By Modulating KLF4 -target gene hsa-mir-7-2 Breast Neoplasms 23384942 miR-7 Suppresses Brain Metastasis of Breast Cancer Stem-Like Cells By Modulating KLF4 -target gene hsa-mir-7-3 Breast Neoplasms 23384942 miR-7 Suppresses Brain Metastasis of Breast Cancer Stem-Like Cells By Modulating KLF4 -target gene hsa-mir-138-1 Ovarian Neoplasms 23389731 MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1a -target gene hsa-mir-138-2 Ovarian Neoplasms 23389731 MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1a -target gene hsa-mir-26a-1 "Carcinoma, Hepatocellular" 23389848 MicroRNA-26a suppresses tumor growth and metastasis of human hepatocellular carcinoma by targeting IL-6-Stat3 pathway -target gene hsa-mir-26a-2 "Carcinoma, Hepatocellular" 23389848 MicroRNA-26a suppresses tumor growth and metastasis of human hepatocellular carcinoma by targeting IL-6-Stat3 pathway -target gene hsa-mir-145 Glioma 23390502 MicroRNA-145 Is Downregulated in Glial Tumors and Regulates Glioma Cell Migration by Targeting Connective Tissue Growth Factor -target gene hsa-mir-17 Glioblastoma 23391506 Stress Response of Glioblastoma Cells Mediated by miR-17-5p Targeting PTEN and the Passenger Strand miR-17-3p Targeting MDM2 -target gene hsa-mir-145 Urinary Bladder Cancer 23392170 "socs7, a target gene of microRNA-145, regulates interferon-alpha induction through STAT3 nuclear translocation in bladder cancer cells" -target gene hsa-mir-130b Endometrial Neoplasms 23392577 miR-130b is an EMT-related microRNA that targets DICER1 for aggression in endometrial cancer -target gene hsa-mir-130a Colorectal Carcinoma 23393589 The Oncogenic Role of microRNA-130a/301a/454 in Human Colorectal Cancer via Targeting Smad4 Expression -target gene hsa-mir-301a Colorectal Carcinoma 23393589 The Oncogenic Role of microRNA-130a/301a/454 in Human Colorectal Cancer via Targeting Smad4 Expression -target gene hsa-mir-454 Colorectal Carcinoma 23393589 The Oncogenic Role of microRNA-130a/301a/454 in Human Colorectal Cancer via Targeting Smad4 Expression -target gene hsa-mir-17 Ovarian Neoplasms 23396109 Downregulation of miR-17~92 Expression Increase Paclitaxel Sensitivity in Human Ovarian Carcinoma SKOV3-TR30 Cells via BIM Instead of PTEN -target gene hsa-mir-92a-1 Ovarian Neoplasms 23396109 Downregulation of miR-17~92 Expression Increase Paclitaxel Sensitivity in Human Ovarian Carcinoma SKOV3-TR30 Cells via BIM Instead of PTEN -target gene hsa-mir-92a-2 Ovarian Neoplasms 23396109 Downregulation of miR-17~92 Expression Increase Paclitaxel Sensitivity in Human Ovarian Carcinoma SKOV3-TR30 Cells via BIM Instead of PTEN -target gene hsa-mir-224 Inflammatory Bowel Diseases 23399735 MicroRNA-224 Negatively Regulates p21 Expression During Late Neoplastic Progression in Inflammatory Bowel Disease -target gene hsa-mir-137 Neuroblastoma 23400681 "miR-137 directly targets KDM1A mRNA in neuroblastoma cells, and activates cell properties consistent with tumor suppression" -target gene hsa-mir-140 "Carcinoma, Hepatocellular" 23401231 MicroRNA-140-5p suppresses tumor growth and metastasis by targeting TGFBR1 and FGF9 in hepatocellular carcinoma -target gene hsa-mir-34c Endometrial Neoplasms 23412924 "Furthermore, miR-34c mimics significantly enhanced apoptosis in Ishikawa cells by inhibiting IL-6R expression. Therefore, a combination of miR-34c mimics and DDP could be an effective therapeutic strategy for controlling Ishikawa cell proliferation." -target gene hsa-mir-92b Glioma 23416699 miR-92b controls glioma proliferation and invasion through regulating Wnt/beta-catenin signaling via Nemo-like kinase -target gene hsa-mir-125b-1 Head And Neck Neoplasms 23416980 Loss of miR-125b-1 contributes to head and neck cancer development by dysregulating TACSTD2 and MAPK pathway -target gene hsa-mir-125b-2 Head And Neck Neoplasms 23416980 Loss of miR-125b-1 contributes to head and neck cancer development by dysregulating TACSTD2 and MAPK pathway -target gene hsa-mir-185 Prostate Neoplasms 23417242 "MicroRNA-185 suppresses proliferation, invasion, migration, and tumorigenicity of human prostate cancer cells through targeting androgen receptor" -target gene hsa-mir-21 Liver Cirrhosis 23417858 Overexpression of microRNA-21 regulating PDCD4 during tumorigenesis of liver fluke-associated cholangiocarcinoma contributes to tumor growth and metastasis -target gene hsa-mir-17 "Carcinoma, Hepatocellular" 23418359 "Mature MiR-17-5p and passenger miR-17-3p induce hepatocellular carcinoma by targeting PTEN, GalNT7, and vimentin in different signal pathways" -target gene hsa-mir-24-1 Neoplasms [unspecific] 23418360 MicroRNA miR-24 Enhances Tumor Invasion and Metastasis by Targeting PTPN9 and PTPRF to Promote EGF Signaling -target gene hsa-mir-24-2 Neoplasms [unspecific] 23418360 MicroRNA miR-24 Enhances Tumor Invasion and Metastasis by Targeting PTPN9 and PTPRF to Promote EGF Signaling -target gene hsa-mir-320d-1 Kaposi Sarcoma 23418466 Cellular MicroRNAs 498 and 320d Regulate Herpes Simplex Virus 1 Induction of Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication by Targeting RTA -target gene hsa-mir-320d-2 Kaposi Sarcoma 23418466 Cellular MicroRNAs 498 and 320d Regulate Herpes Simplex Virus 1 Induction of Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication by Targeting RTA -target gene hsa-mir-498 Kaposi Sarcoma 23418466 Cellular MicroRNAs 498 and 320d Regulate Herpes Simplex Virus 1 Induction of Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication by Targeting RTA -target gene hsa-mir-34c Gastric Neoplasms 23423488 Regulation of microtubule-associated protein tau (MAPT) by miR-34c-5p determines the chemosensitivity of gastric cancer to paclitaxel -target gene hsa-mir-125b-1 Urinary Bladder Cancer 23425975 microRNA-125b inhibits cell migration and invasion by targeting matrix metallopeptidase 13 in bladder cancer -target gene hsa-mir-125b-2 Urinary Bladder Cancer 23425975 microRNA-125b inhibits cell migration and invasion by targeting matrix metallopeptidase 13 in bladder cancer -target gene hsa-mir-34a Acute Myocardial Infarction 23426265 "these results identify age-induced expression of miR-34a and inhibition of its target PNUTS as a key mechanism that regulates cardiac contractile function during ageing and after acute myocardial infarction, by inducing DNA damage responses and telomere attrition." -target gene hsa-mir-154 Prostate Neoplasms 23428540 miR-154 inhibits prostate cancer cell proliferation by targeting CCND2 -target gene hsa-mir-570 Gastric Neoplasms 23430453 A miR-570 binding site polymorphism in the B7-H1 gene is associated with the risk of gastric adenocarcinoma -target gene hsa-mir-182 Breast Neoplasms 23430586 Expression and regulatory function of miRNA-182 in triple-negative breast cancer cells through its targeting of profilin 1 -target gene hsa-mir-181b-1 Glioma 23431408 MiRNA-181b suppresses IGF-1R and functions as a tumor suppressor gene in gliomas -target gene hsa-mir-181b-2 Glioma 23431408 MiRNA-181b suppresses IGF-1R and functions as a tumor suppressor gene in gliomas -target gene hsa-mir-25 Colorectal Carcinoma 23435373 MicroRNA-25 functions as a potential tumor suppressor in colon cancer by targeting Smad7 -target gene hsa-mir-146a Gastric Neoplasms 23435376 MicroRNA-146a acts as a metastasis suppressor in gastric cancer by targeting WASF2 -target gene hsa-mir-1 Heart Failure 23436819 The decrease of miR-1 and increase of AnxA5 appear as important modulators of NCX1 expression and activity during heart failure. -target gene hsa-mir-155 Laryngeal Neoplasms 23437123 Overexpression of miR -155 Promotes Proliferation and Invasion of Human Laryngeal Squamous Cell Carcinoma via Targeting SOCS1 and STAT3 -target gene hsa-mir-23a "Adenocarcinoma, Lung" 23437179 "Among them, we confirmed TGF-¦Â-mediated induction of miR-23a in lung epithelial cell lines,target genes of which were further identified by gene expression profiling." -target gene hsa-mir-126 Melanoma 23437250 miR-126&126* Restored Expressions Play a Tumor Suppressor Role by Directly Regulating ADAM9 and MMP7 in Melanoma -target gene hsa-mir-27a Ovarian Neoplasms 23438830 Oncogenic MicroRNA-27a is a Target for Genistein in Ovarian Cancer Cells -target gene hsa-mir-135a-1 Neoplasms [unspecific] 23438844 "MiR-138 and MiR-135 Directly Target Focal Adhesion Kinase, Inhibit Cell Invasion, and Increase Sensitivity to Chemotherapy in Cancer Cells" -target gene hsa-mir-135a-2 Neoplasms [unspecific] 23438844 "MiR-138 and MiR-135 Directly Target Focal Adhesion Kinase, Inhibit Cell Invasion, and Increase Sensitivity to Chemotherapy in Cancer Cells" -target gene hsa-mir-138-1 Neoplasms [unspecific] 23438844 "MiR-138 and MiR-135 Directly Target Focal Adhesion Kinase, Inhibit Cell Invasion, and Increase Sensitivity to Chemotherapy in Cancer Cells" -target gene hsa-mir-138-2 Neoplasms [unspecific] 23438844 "MiR-138 and MiR-135 Directly Target Focal Adhesion Kinase, Inhibit Cell Invasion, and Increase Sensitivity to Chemotherapy in Cancer Cells" -target gene hsa-mir-181b "Adenocarcinoma, Pancreatic Ductal" 23440261 miRNA-181b increases the sensitivity of pancreatic ductal adenocarcinoma cells to gemcitabine in vitro and in nude mice by targeting BCL-2. -target gene hsa-mir-145 "Carcinoma, Renal Cell" 23441135 MicroRNA-145 Targets the Metalloprotease ADAM17 and Is Suppressed in Renal Cell Carcinoma Patients -target gene hsa-mir-29c Gastric Neoplasms 23442884 MiR-29c is downregulated in gastric carcinomas and regulates cell proliferation by targeting RCC2 -target gene hsa-mir-30a Breast Neoplasms 23445407 MicroRNA miR-30 family regulates non-attachment growth of breast cancer cells -target gene hsa-mir-21 Multiple Myeloma 23446999 Targeting miR-21 inhibits in vitro and in vivo multiple myeloma cell growth -target gene hsa-mir-378a Cardiomegaly 23447532 "A cardiac enriched microRNA, miR-378 blocks cardiac hypertrophy by targeting Ras-signaling" -target gene hsa-mir-210 "Carcinoma, Renal Cell" 23449350 "miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis" -target gene hsa-mir-27a Hepatitis C Virus Infection 23449803 MicroRNA-27a regulates lipid metabolism and inhibits hepatitis C virus replication in human hepatoma cells -target gene hsa-mir-23a Endometriosis 23450049 MicroRNA23a and MicroRNA23b Deregulation Derepresses SF-1 and Upregulates Estrogen Signaling in Ovarian Endometriosis -target gene hsa-mir-23b Endometriosis 23450049 MicroRNA23a and MicroRNA23b Deregulation Derepresses SF-1 and Upregulates Estrogen Signaling in Ovarian Endometriosis -target gene hsa-mir-30a Systemic Lupus Erythematosus 23450709 MicroRNA-30a promotes B cell hyperactivity in patient with SLE by direct interaction with LYN -target gene hsa-mir-133b Prostate Neoplasms 23451058 "miR-133b is directly up-regulated by AR, and represses CDC2L5, PTPRK, RB1CC1, and CPNE3, respectively. Moreover, we found miR-133b is essential to PCa cell survival. " -target gene hsa-mir-19a Prostate Neoplasms 23451058 "miR-19a is directly up-regulated by AR, and represses SUZ12, RAB13, SC4MOL, PSAP and ABCA1, respectively. " -target gene hsa-mir-27a Prostate Neoplasms 23451058 "miR-27a is directly up-regulated by AR, and represses ABCA1 and PDS5B. " -target gene hsa-mir-497 Urinary Bladder Cancer 23453369 MicroRNA-497 is a potential prognostic marker in human cervical cancer and functions as a tumor suppressor by targeting the insulin-like growth factor 1 receptor -target gene hsa-let-7i "Squamous Cell Carcinoma, Head and Neck" 23454123 "In clinical HNSCC samples, let-7i expression was inversely correlated with BMP4 expression. Our results revealed that let-7i attenuates mesenchymal-mode migration of HNSCC cells through repression of a novel target, BMP4." -target gene hsa-mir-218-1 "Carcinoma, Renal Cell" 23454155 microRNA-218 inhibits cell migration and invasion in renal cell carcinoma through targeting caveolin-2 involved in focal adhesion pathway -target gene hsa-mir-218-2 "Carcinoma, Renal Cell" 23454155 microRNA-218 inhibits cell migration and invasion in renal cell carcinoma through targeting caveolin-2 involved in focal adhesion pathway -target gene hsa-mir-146a Thyroid Neoplasms 23457043 MicroRNA-146a targets PRKCE to modulate papillary thyroid tumor development -target gene hsa-mir-152 Prostate Neoplasms 23460133 miR-152 controls migration and invasive potential by targeting TGF¦Á in prostate cancer cell lines -target gene hsa-mir-21 Gastric Neoplasms 23466500 miR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN -target gene hsa-mir-134 Glioblastoma 23467648 MiR-134 regulates the proliferation and invasion of glioblastoma cells by reducing Nanog expression -target gene hsa-mir-195 "Carcinoma, Hepatocellular" 23468064 "MicroRNA-195 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting the expression of VEGF, VAV2 and CDC42" -target gene hsa-mir-3148 Systemic Lupus Erythematosus 23468661 MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus -target gene hsa-mir-216a "Carcinoma, Hepatocellular" 23471579 MiR-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer -target gene hsa-mir-217 "Carcinoma, Hepatocellular" 23471579 MiR-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer -target gene hsa-mir-27a Colorectal Carcinoma 23471840 The drug resistance suppression induced by curcuminoids in colon cancer SW-480 cells is mediated by reactive oxygen species-induced disruption of the microRNA-27a-ZBTB10-Sp axis -target gene hsa-mir-183 Sensorineural Hearing Loss 23472202 The miR-183/Taok1 target pair is implicated in cochlear responses to acoustic trauma. -target gene hsa-mir-182 Breast Neoplasms 23474751 Suppression of MIM by microRNA-182 activates RhoA and promotes breast cancer metastasis -target gene hsa-mir-486 Lung Neoplasms 23474761 Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer -target gene hsa-mir-214 Nasopharyngeal Neoplasms 23479198 miR-214 promotes tumorigenesis by targeting lactotransferrin in nasopharyngeal carcinoma -target gene hsa-mir-21 Cholangiocarcinoma 23480766 "The expression level of miR-21 had an inverse correlation with the mRNA level of its target RECK, a metastasis suppressor, in human CCA" -target gene hsa-mir-145 Prostate Neoplasms 23480797 The proto-oncogene ERG is a target of microRNA miR-145 in prostate cancer -target gene hsa-mir-218-1 Cervical Neoplasms 23483249 Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion by targeting focal adhesion pathways in cervical squamous cell carcinoma -target gene hsa-mir-218-2 Cervical Neoplasms 23483249 Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion by targeting focal adhesion pathways in cervical squamous cell carcinoma -target gene hsa-mir-30a Colorectal Carcinoma 23486085 miR-30a Suppresses Cell Migration and Invasion Through Downregulation of PIK3CD in Colorectal Carcinoma -target gene hsa-mir-195 "Carcinoma, Hepatocellular" 23487264 Genome-wide screening revealed that miR-195 targets the TNF-alpha/NF-kB pathway by downregulating IKK and TAB3 in hepatocellular carcinoma -target gene hsa-mir-205 Neoplasms [unspecific] 23487795 Arf tumor suppressor and miR-205 regulate cell adhesion and formation of extraembryonic endoderm from pluripotent stem cells -target gene hsa-mir-93 Breast Neoplasms 23492819 MicroRNA-93 regulates NRF2 expression and is associated with breast carcinogenesis. -target gene hsa-mir-29b-1 "Leukemia, Myeloid, Acute" 23493348 Targeted Delivery of microRNA-29b by Transferrin Conjugated Anionic Lipopolyplex Nanoparticles: A Novel Therapeutic Strategy in Acute Myeloid Leukemia -target gene hsa-mir-29b-2 "Leukemia, Myeloid, Acute" 23493348 Targeted Delivery of microRNA-29b by Transferrin Conjugated Anionic Lipopolyplex Nanoparticles: A Novel Therapeutic Strategy in Acute Myeloid Leukemia -target gene hsa-mir-93 Polycystic Ovarian Syndrome 23493574 miRNA-93 inhibits GLUT4 and is overexpressed in adipose tissue of Polycystic Ovary Syndrome patients and women with insulin resistance -target gene hsa-mir-145 Colorectal Carcinoma 23499891 Tumor-suppressive microRNA-145 targets catenin to regulate Wnt/beta-catenin signaling in human colon cancer cells -target gene hsa-mir-145 "Carcinoma, Hepatocellular" 23499894 MiR-145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer -target gene hsa-mir-21 Esophageal Neoplasms 23504349 "miR-21 Down-Regulation Suppresses Cell Growth, Invasion and Induces Cell Apoptosis by Targeting FASL, TIMP3, and RECK Genes in Esophageal Carcinoma" -target gene hsa-mir-16-1 Osteosarcoma 23507142 miR-16 inhibits cell proliferation by targeting IGF1R and the Raf1-MEK1/2-ERK1/2 pathway in osteosarcoma -target gene hsa-mir-16-2 Osteosarcoma 23507142 miR-16 inhibits cell proliferation by targeting IGF1R and the Raf1-MEK1/2-ERK1/2 pathway in osteosarcoma -target gene hsa-mir-30e Renal Fibrosis 23515048 A microRNA-30e/mitochondrial uncoupling protein 2 axis mediates TGF-¦Â1-induced tubular epithelial cell extracellular matrix production and kidney fibrosis. -target gene hsa-mir-181a Inflammation 23516523 we provide the first evidence for anti-inflammatory effects of miR-181a mediated at least in part by down-regulating IL1a. -target gene hsa-mir-150 Lymphoma 23521217 Re-expression of miR-150 induces EBV-positive Burkitt lymphoma differentiation by modulating c-Myb in vitro -target gene hsa-mir-9 Inflammation 23525285 MicroRNA-9 regulates the expression of peroxisome proliferator-activated receptor ¦Ä in human monocytes during the inflammatory response. -target gene hsa-mir-195 Colorectal Carcinoma 23526568 MicroRNA-195 chemosensitizes colon cancer cells to the chemotherapeutic drug doxorubicin by targeting the first binding site of BCL2L2 mRNA -target gene hsa-mir-128-1 Breast Neoplasms 23526655 Downregulation of miRNA-128 sensitizes breast cancer cell to chemodrugs by targeting Bax -target gene hsa-mir-128-2 Breast Neoplasms 23526655 Downregulation of miRNA-128 sensitizes breast cancer cell to chemodrugs by targeting Bax -target gene hsa-mir-22 Gastric Neoplasms 23529765 "miR-22 is down-regulated in gastric cancer, and its overexpression inhibits cell migration and invasion via targeting transcription factor Sp1" -target gene hsa-mir-9-1 Breast Neoplasms 23530058 miR-9-3p targets integrin beta 1 to sensitize claudin-low breast cancer cells to MEK inhibition -target gene hsa-mir-9-2 Breast Neoplasms 23530058 miR-9-3p targets integrin beta 1 to sensitize claudin-low breast cancer cells to MEK inhibition -target gene hsa-mir-9-3 Breast Neoplasms 23530058 miR-9-3p targets integrin beta 1 to sensitize claudin-low breast cancer cells to MEK inhibition -target gene hsa-mir-497 Neuroblastoma 23531080 MicroRNA-497 increases apoptosis in MYCN amplified neuroblastoma cells by targeting the key cell cycle regulator WEE1 -target gene hsa-mir-34a Neoplasms [unspecific] 23533633 "CD24 Induces Expression of the Oncomir miR-21 via Src, and CD24 and Src Are Both Post-Transcriptionally Downregulated by the Tumor Suppressor miR-34a" -target gene hsa-mir-148a Asthma 23534973 These combined results are consistent with +3142 allele-specific targeting of HLA-G by the miR-152 family and support our hypothesis that miRNA regulation of sHLA-G in the airway is influenced by both the asthma status of the subject's mother and the subject's genotype. -target gene hsa-mir-148b Asthma 23534973 These combined results are consistent with +3142 allele-specific targeting of HLA-G by the miR-152 family and support our hypothesis that miRNA regulation of sHLA-G in the airway is influenced by both the asthma status of the subject's mother and the subject's genotype. -target gene hsa-mir-152 Asthma 23534973 These combined results are consistent with +3142 allele-specific targeting of HLA-G by the miR-152 family and support our hypothesis that miRNA regulation of sHLA-G in the airway is influenced by both the asthma status of the subject's mother and the subject's genotype. -target gene hsa-mir-183 Prostate Neoplasms 23538390 microRNA-183 is an oncogene targeting Dkk-3 and SMAD4 in prostate cancer -target gene hsa-mir-31 Neoplasms [unspecific] 23539435 MicroRNA-31-5p modulates cell cycle by targeting human mutL homolog 1 in human cancer cells -target gene hsa-mir-200b Glioma 23543137 MicroRNA-200b targets CREB1 and suppresses cell growth in human malignant glioma -target gene hsa-mir-195 "Carcinoma, Hepatocellular" 23544130 The Tumor-Suppressive miR-497-195 Cluster Targets Multiple Cell-Cycle Regulators in Hepatocellular Carcinoma -target gene hsa-mir-497 "Carcinoma, Hepatocellular" 23544130 The Tumor-Suppressive miR-497-195 Cluster Targets Multiple Cell-Cycle Regulators in Hepatocellular Carcinoma -target gene hsa-mir-145 Head And Neck Neoplasms 23548270 miR145 targets the SOX9/ADAM17 axis to inhibit tumor initiating cells and IL-6-mediated paracrine effects in head and neck cancer -target gene hsa-mir-148a Gastric Neoplasms 23549984 MicroRNA-148a can regulate runt-related transcription factor 3 gene expression via modulation of DNA methyltransferase 1 in gastric cancer -target gene hsa-mir-139 Glioma 23551751 MiR-139 Inhibits Mcl-1 Expression and Potentiates TMZ-Induced Apoptosis in Glioma -target gene hsa-mir-15a Leukemia 23551855 miR-15a/16-1 is known to regulate Bcl2 in chronic lymphocytic leukemia -target gene hsa-mir-16-1 Leukemia 23551855 miR-15a/16-1 is known to regulate Bcl2 in chronic lymphocytic leukemia -target gene hsa-mir-23a Gastric Neoplasms 23553990 MiR-23a in Amplified 19p13.13 Loci Targets Metallothionein 2A and Promotes Growth in Gastric Cancer Cells -target gene hsa-mir-874 "Squamous Cell Carcinoma, Head and Neck" 23558898 Tumour-suppressive microRNA-874 contributes to cell proliferation through targeting of histone deacetylase 1 in head and neck squamous cell carcinoma -target gene hsa-mir-21 "Carcinoma, Renal Cell" 23558936 "MiR-21 is overexpressed in RCC tissue and modulates the growth, apoptosis and cell cycle progression of RCC cells and regulates the expression of PDCD4 and TPM1" -target gene hsa-mir-205 "Carcinoma, Nasopharyngeal" 23564023 "Our research group established the radioresistant NPC cell line CNE2R derived from the CNE2 cell line, and demonstrated that irradiation-induced miR-205 determined the resistance of NPC through directly targeting PTEN." -target gene hsa-mir-383 Glioma 23564324 Downregulation of miR-383 promotes glioma cell invasion by targeting insulin-like growth factor 1 receptor -target gene hsa-mir-34a Osteosarcoma 23569431 MicroRNA-34a Inhibits Human Osteosarcoma Proliferation by Downregulating Ether go-go 1 Expression -target gene hsa-mir-205 Prostate Neoplasms 23571738 miR-205 negatively regulates the androgen receptor and is associated with adverse outcome of prostate cancer patients -target gene hsa-mir-155 Viral Infectious Disease 23572582 "NK cells constitutively expressing Noxa and SOCS1 exhibit profound defects in expansion during the response to MCMV infection, suggesting that their regulation by miR-155 promotes antiviral immunity." -target gene hsa-mir-370 Gastric Neoplasms 23576572 Fork head box M1 is overexpressed in Helicobacter pylori-induced gastric carcinogenesis and is negatively regulated by hsa-miR-370 -target gene hsa-mir-24-1 Osteosarcoma 23578572 MicroRNA-24 Inhibits Osteosarcoma Cell Proliferation Both In Vitro and In Vivo by Targeting LPAAT -target gene hsa-mir-24-2 Osteosarcoma 23578572 MicroRNA-24 Inhibits Osteosarcoma Cell Proliferation Both In Vitro and In Vivo by Targeting LPAAT -target gene hsa-mir-193a Ovarian Neoplasms 23588298 We demonstrated that miR-193a decreased the amount of MCL1 protein by binding 3'UTR of its mRNA. -target gene hsa-mir-155 "Leukemia, Lymphocytic, Chronic, B-Cell" 23597135 "Here we review studies that provide evidence suggesting that certain miRNAs (e.g. miR-155, miR-17-92, miR-181, miR-29) can regulate the activated phenotype of CLL cells and/or fitness of the surface-immunoglobulin (sIg) B cell receptor (BCR) complex expressed by CLL cells, thereby accounting for the differential leukemia-cell expression of these miRNAs in different CLL prognostic subgroups." -target gene hsa-mir-17 "Leukemia, Lymphocytic, Chronic, B-Cell" 23597135 "Here we review studies that provide evidence suggesting that certain miRNAs (e.g. miR-155, miR-17-92, miR-181, miR-29) can regulate the activated phenotype of CLL cells and/or fitness of the surface-immunoglobulin (sIg) B cell receptor (BCR) complex expressed by CLL cells, thereby accounting for the differential leukemia-cell expression of these miRNAs in different CLL prognostic subgroups." -target gene hsa-mir-18 "Leukemia, Lymphocytic, Chronic, B-Cell" 23597135 "Here we review studies that provide evidence suggesting that certain miRNAs (e.g. miR-155, miR-17-92, miR-181, miR-29) can regulate the activated phenotype of CLL cells and/or fitness of the surface-immunoglobulin (sIg) B cell receptor (BCR) complex expressed by CLL cells, thereby accounting for the differential leukemia-cell expression of these miRNAs in different CLL prognostic subgroups." -target gene hsa-mir-181 "Leukemia, Lymphocytic, Chronic, B-Cell" 23597135 "Here we review studies that provide evidence suggesting that certain miRNAs (e.g. miR-155, miR-17-92, miR-181, miR-29) can regulate the activated phenotype of CLL cells and/or fitness of the surface-immunoglobulin (sIg) B cell receptor (BCR) complex expressed by CLL cells, thereby accounting for the differential leukemia-cell expression of these miRNAs in different CLL prognostic subgroups." -target gene hsa-mir-19a "Leukemia, Lymphocytic, Chronic, B-Cell" 23597135 "Here we review studies that provide evidence suggesting that certain miRNAs (e.g. miR-155, miR-17-92, miR-181, miR-29) can regulate the activated phenotype of CLL cells and/or fitness of the surface-immunoglobulin (sIg) B cell receptor (BCR) complex expressed by CLL cells, thereby accounting for the differential leukemia-cell expression of these miRNAs in different CLL prognostic subgroups." -target gene hsa-mir-19b-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 23597135 "Here we review studies that provide evidence suggesting that certain miRNAs (e.g. miR-155, miR-17-92, miR-181, miR-29) can regulate the activated phenotype of CLL cells and/or fitness of the surface-immunoglobulin (sIg) B cell receptor (BCR) complex expressed by CLL cells, thereby accounting for the differential leukemia-cell expression of these miRNAs in different CLL prognostic subgroups." -target gene hsa-mir-20a "Leukemia, Lymphocytic, Chronic, B-Cell" 23597135 "Here we review studies that provide evidence suggesting that certain miRNAs (e.g. miR-155, miR-17-92, miR-181, miR-29) can regulate the activated phenotype of CLL cells and/or fitness of the surface-immunoglobulin (sIg) B cell receptor (BCR) complex expressed by CLL cells, thereby accounting for the differential leukemia-cell expression of these miRNAs in different CLL prognostic subgroups." -target gene hsa-mir-29 "Leukemia, Lymphocytic, Chronic, B-Cell" 23597135 "Here we review studies that provide evidence suggesting that certain miRNAs (e.g. miR-155, miR-17-92, miR-181, miR-29) can regulate the activated phenotype of CLL cells and/or fitness of the surface-immunoglobulin (sIg) B cell receptor (BCR) complex expressed by CLL cells, thereby accounting for the differential leukemia-cell expression of these miRNAs in different CLL prognostic subgroups." -target gene hsa-mir-92-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 23597135 "Here we review studies that provide evidence suggesting that certain miRNAs (e.g. miR-155, miR-17-92, miR-181, miR-29) can regulate the activated phenotype of CLL cells and/or fitness of the surface-immunoglobulin (sIg) B cell receptor (BCR) complex expressed by CLL cells, thereby accounting for the differential leukemia-cell expression of these miRNAs in different CLL prognostic subgroups." -target gene hsa-mir-19a Gastrointestinal Neoplasms 23603256 MicroRNA-19a/b regulates multidrug resistance in human gastric cancer cells by targeting PTEN. -target gene hsa-mir-19b Gastrointestinal Neoplasms 23603256 MicroRNA-19a/b regulates multidrug resistance in human gastric cancer cells by targeting PTEN. -target gene hsa-mir-150 Leukemia 23604034 "In conclusion, we demonstrate that miR-150 is a potent leukemic tumor suppressor that regulates multiple oncogenes." -target gene hsa-mir-101 Bladder Neoplasms 23618864 MicroRNA-101 suppresses motility of bladder cancer cells by targeting c-Met. -target gene hsa-mir-21 Cholangiocarcinoma 23621247 MicroRNA-21 regulates the invasion and metastasis in cholangiocarcinoma and may be a potential biomarker for cancer prognosis. -target gene hsa-mir-19a Gastrointestinal Neoplasms 23621248 miR-19a promotes cell growth and tumorigenesis through targeting SOCS1 in gastric cancer. -target gene hsa-mir-145 "Carcinoma, Hepatocellular" 23621665 miR-145 suppresses cell invasion in hepatocellular carcinoma cells: miR-145 targets ADAM17. -target gene hsa-mir-135b Breast Neoplasms 23623609 miR-135b coordinates progression of ErbB2-driven mammary carcinomas through suppression of MID1 and MTCH2. -target gene hsa-mir-124 Glioblastoma 23624869 Downregulation of miR-124 promotes the growth and invasiveness of glioblastoma cells involving upregulation of PPP1R13L. -target gene hsa-mir-124 Glioblastoma 23636127 miR-124 inhibits STAT3 signaling to enhance T cell-mediated immune clearance of glioma. -target gene hsa-mir-205 Melanoma 23638671 Our data suggest that miR-203 is a new prognostic factor in canine oral MMs and that miR-205 functions as a tumour suppressor by targeting erbb3 in both canine and human MM cells. -target gene hsa-mir-143 "Adenocarcinoma, Pancreatic Ductal" 23661430 "SEL1L mRNA expression levels were found to correlate inversely with the expression of hsa-mir-143, hsa-mir-155, and hsa-mir-223 (P?A mutation in the GFPT1 gene leads to illegitimate binding of microRNA resulting in reduced protein expression. We confirm that c.*22C>A is a causative mutation and suggest that formation of microRNA target sites might be a relevant pathomechanism in Mendelian disorders. Variants in the 3'-UTRs should be considered in genetic diagnostic procedures. -target gene hsa-mir-940 "Adenocarcinoma, Pancreatic Ductal" 25766528 Low level of miR-940 and high level of MyD88 in PDAC promoted PDAC cells growth which might be related to the low survival rate of PDAC patients.MiR-940 exerted its effect by targeting MyD88. -target gene hsa-mir-122 Hepatitis B Virus Infection 25766860 Down-regulation of suppressor of cytokine signaling 3 by miR-122 enhances interferon-mediated suppression of hepatitis B virus. -target gene hsa-mir-21 "Carcinoma, Cervical" 25769949 miR-21 modulates resistance of HR-HPV positive cervical cancer cells to radiation through targeting LATS1. -target gene hsa-mir-199a Colorectal Carcinoma 25772759 FZD6 expression is negatively regulated by miR-199a-5p in human colorectal cancer. -target gene hsa-mir-155 Chronic Hepatitis C 25772938 MicroRNA-155 regulates interferon-¦Ã production in natural killer cells via Tim-3 signalling in chronic hepatitis C virus infection. -target gene hsa-mir-191 Osteosarcoma 25773391 MicroRNA-191 promotes osteosarcoma cells proliferation by targeting checkpoint kinase 2. -target gene hsa-mir-196a Gastric Neoplasms 25773825 "Overexpression of mir-196a-5p is associated with lymph node metastasis and clinical stage, and enriched KEGG pathway analyses showed that targeted genes regulated by mir-196a-5p may contribute to tumorgenesis,suggesting roles as an oncogenic miRNA biomarker in gastric cancer." -target gene hsa-mir-155 Systemic Lupus Erythematosus 25775145 "The results of the present study demonstrated for the first time that there is a differential expression and inverse correlation between the levels the miR-155, miR-17, and miR-181b and target molecules, AID and IFN-¦Á mRNAs, in PBMCs of untreated SLE patients. These alterations may contribute to the pathogenesis of SLE." -target gene hsa-mir-17 Systemic Lupus Erythematosus 25775145 "The results of the present study demonstrated for the first time that there is a differential expression and inverse correlation between the levels the miR-155, miR-17, and miR-181b and target molecules, AID and IFN-¦Á mRNAs, in PBMCs of untreated SLE patients. These alterations may contribute to the pathogenesis of SLE." -target gene hsa-mir-181b Systemic Lupus Erythematosus 25775145 "The results of the present study demonstrated for the first time that there is a differential expression and inverse correlation between the levels the miR-155, miR-17, and miR-181b and target molecules, AID and IFN-¦Á mRNAs, in PBMCs of untreated SLE patients. These alterations may contribute to the pathogenesis of SLE." -target gene hsa-mir-215 Colorectal Carcinoma 25775580 The CDX1-microRNA-215 axis regulates colorectal cancer stem cell differentiation. -target gene hsa-mir-377 "Carcinoma, Renal Cell, Clear-Cell" 25776481 miR-377 functions as a tumor suppressor in human clear cell renal cell carcinoma by targeting ETS1. -target gene hsa-mir-325 "Carcinoma, Lung, Non-Small-Cell" 25776482 Expression of MicroRNA-325-3p and its potential functions by targeting HMGB1 in non-small cell lung cancer. -target gene hsa-mir-183 Pancreatic Neoplasms 25776494 "miR-183 induces cell proliferation, migration, and invasion by regulating PDCD4 expression in the SW1990 pancreatic cancer cell line." -target gene hsa-mir-411 "Carcinoma, Hepatocellular" 25776495 miR-411 regulated ITCH expression and promoted cell proliferation in human hepatocellular carcinoma cells. -target gene hsa-mir-522 Glioblastoma 25776496 MiR-522 contributes to cell proliferation of human glioblastoma cells by suppressing PHLPP1 expression. -target gene hsa-mir-423 Chronic Heart Failure 25776937 the results of the present study indicated that miR-423-5p was involved in CHF via the direct targeting of OGT and the induction of apoptosis in cardiomyocytes. -target gene hsa-mir-27a Glioma 25777779 Emerging role of microRNA-27a in human malignant glioma cell survival via targeting of prohibitin. -target gene hsa-mir-128 Glioma 25781272 Proteomic screening and identification of microRNA-128 targets in glioma cells. -target gene hsa-mir-224 Meningioma 25783051 MicroRNA-224 targets ERG2 and contributes to malignant progressions of meningioma. -target gene hsa-mir-15b Breast Neoplasms 25783158 EGF induces microRNAs that target suppressors of cell migration: miR-15b targets MTSS1 in breast cancer. -target gene hsa-mir-34a Breast Neoplasms 25783790 MicroRNA-34a suppresses the breast cancer stem cell-like characteristics by downregulating Notch1 pathway. -target gene hsa-mir-191 Colorectal Carcinoma 25784653 miR-191 promotes tumorigenesis of human colorectal cancer through targeting C/EBP¦Â. -target gene hsa-mir-17 Atherosclerosis 25785043 miR-93 and miR-17 repress ABCA1 expression through directly targeting 3'UTR. -target gene hsa-mir-29a "Carcinoma, Nasopharyngeal" 25786138 miR-29a/b enhances cell migration and invasion in nasopharyngeal carcinoma progression by regulating SPARC and COL3A1 gene expression. -target gene hsa-mir-29b "Carcinoma, Nasopharyngeal" 25786138 miR-29a/b enhances cell migration and invasion in nasopharyngeal carcinoma progression by regulating SPARC and COL3A1 gene expression. -target gene hsa-mir-34a Leukemia 25788289 MiR-34a regulates blood-tumor barrier function by targeting protein kinase C¦Å. -target gene hsa-mir-200c Cardiovascular Diseases [unspecific] 25791170 These results demonstrate that induction of a miR-200c-SUMOylated KLF4 feedback loop is a significant aspect of the PDGF-BB proliferative response in VSMCs and that targeting Ubc9 represents a novel approach for the prevention of restenosis. -target gene hsa-mir-153 Osteosarcoma 25793604 MicroRNA-153 inhibits osteosarcoma cells proliferation and invasion by targeting TGF-¦Â2. -target gene hsa-mir-153 Breast Neoplasms 25794773 MiR-153 inhibits epithelial-mesenchymal transition by targeting metadherin in human breast cancer. -target gene hsa-mir-204 Prostate Neoplasms 25797256 A dual yet opposite growth-regulating function of miR-204 and its target XRN1 in prostate adenocarcinoma cells and neuroendocrine-like prostate cancer cells. -target gene hsa-mir-31 Liver Neoplasms 25797269 MicroRNA-31 functions as a tumor suppressor by regulating cell cycle and epithelial-mesenchymal transition regulatory proteins in liver cancer. -target gene hsa-mir-182 Lung Neoplasms 25798833 The miR-200 family and the miR-183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers. -target gene hsa-mir-183 Lung Neoplasms 25798833 The miR-200 family and the miR-183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers. -target gene hsa-mir-200 Lung Neoplasms 25798833 The miR-200 family and the miR-183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers. -target gene hsa-mir-96 Lung Neoplasms 25798833 The miR-200 family and the miR-183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers. -target gene hsa-mir-30c Colorectal Carcinoma 25799050 Role of microRNA-30c targeting ADAM19 in colorectal cancer. -target gene hsa-mir-194 "Adenocarcinoma, Gastric" 25800782 "We showed evidence that HNF4γ (upregulated in intestinal metaplasia) is targeted by miR-30 and that miR-194 targets a known co-regulator of HNF4 activity, NR2F2 (downregulated in intestinal metaplasia)." -target gene hsa-mir-30a "Adenocarcinoma, Gastric" 25800782 "We showed evidence that HNF4γ (upregulated in intestinal metaplasia) is targeted by miR-30 and that miR-194 targets a known co-regulator of HNF4 activity, NR2F2 (downregulated in intestinal metaplasia)." -target gene hsa-mir-26a Atherosclerosis 25801675 MicroRNA-26a prevents endothelial cell apoptosis by directly targeting TRPC6 in the setting of atherosclerosis. -target gene hsa-mir-152 Diabetic Retinopathy 25802486 "We have demonstrated that miR-152 interacting with PRR regulates downstream VEGF, VRGFR-2, and TGF¦Â1 expressions in hRECs in HG conditions. These studies suggest miR-152 and PRR may play a role in the pathogenesis of diabetic retinopathy (DR)." -target gene hsa-mir-21 Cholangiocarcinoma 25803229 MiR-21 promotes intrahepatic cholangiocarcinoma proliferation and growth in vitro and in vivo by targeting PTPN14 and PTEN. -target gene hsa-mir-146a Hepatitis B Virus Infection 25805734 Upregulation of microRNA-146a by hepatitis B virus X protein contributes to hepatitis development by downregulating complement factor H. -target gene hsa-mir-28 Ischemic Diseases [unspecific] 25807426 These findings suggest that miR-28 promotes myocardial ischemia through the inhibition of ALDH2 expression in mus. miRNAs is as a probable index in identification of myocardial ischemia after acute myocardial infarction. -target gene hsa-mir-106b Pancreatic Neoplasms 25807437 Our findings may provide new insights into the knowledge of molecular mechanisms of pancreatic cancer and development of novel targeting therapies. -target gene hsa-mir-125a Pancreatic Neoplasms 25807437 Our findings may provide new insights into the knowledge of molecular mechanisms of pancreatic cancer and development of novel targeting therapies. -target gene hsa-mir-153 Pancreatic Neoplasms 25807437 Our findings may provide new insights into the knowledge of molecular mechanisms of pancreatic cancer and development of novel targeting therapies. -target gene hsa-mir-181c Pancreatic Neoplasms 25807437 Our findings may provide new insights into the knowledge of molecular mechanisms of pancreatic cancer and development of novel targeting therapies. -target gene hsa-mir-101 "Carcinoma, Hepatocellular" 25808945 Our results demonstrate that miR-101 regulates HCC cell phenotype by upregulating the epithelial marker genes and suppressing the mesenchymal ones. -target gene hsa-mir-221 Inflammation 25810396 "Moreover, downregulation of KIT expression by miRNA-221 overexpression or the proteasome inhibitor bortezomib also reduced 3BP2 and MITF expression." -target gene hsa-mir-134 "Carcinoma, Renal Cell" 25811077 miR-134 functions as a tumor suppressor in cell proliferation and epithelial-to-mesenchymal Transition by targeting KRAS in renal cell carcinoma cells. -target gene hsa-mir-155 Stroke 25811992 miR-155 mediates inflammatory responses in ischemic cerebral tissue by modulating TLR4/MyD88 and SOCS1 expression -target gene hsa-mir-218 Cardiac Myxoma 25812649 miR-218 suppresses cardiac myxoma proliferation by targeting myocyte enhancer factor 2D. -target gene hsa-mir-200a "Carcinoma, Renal Cell" 25813153 Tumor suppressive microRNA-200a inhibits renal cell carcinoma development by directly targeting TGFB2. -target gene hsa-mir-141 Breast Neoplasms 25813250 miR-141 confers docetaxel chemoresistance of breast cancer cells via regulation of EIF4E expression. -target gene hsa-mir-7 Parkinson Disease 25814668 "microRNA-7, by down-regulating RelA,augments Glut3 expression, promotes glycolysis, and subsequently prevents MPP(+)-induced cell death. This protective effect of microRNA-7 could be exploited to correct the defects in oxidative phosphorylation in Parkinson disease." -target gene hsa-mir-200b "Diabetes Mellitus, Type 2" 25814674 This study reports that (1) inflammation underlying nonhealing wounds in patients with type 2 diabetes mellitus influences plasma miRNA concentrations and (2) miR-191 modulates cellular migration and angiogenesis via paracrine regulation of zonula occludens-1 to delay the tissue repair process. -target gene hsa-mir-191 "Carcinoma, Hepatocellular, HBV-Related" 25814782 "These findings highlight the importance of validating reference genes before quantifying target miRNAs.Furthermore, our findings will improve studies that monitor hepatitis progression and will aid in the discovery of noninvasive biomarkers to diagnose early stage HCC." -target gene hsa-mir-221 "Carcinoma, Hepatocellular, HBV-Related" 25814782 "These findings highlight the importance of validating reference genes before quantifying target miRNAs.Furthermore, our findings will improve studies that monitor hepatitis progression and will aid in the discovery of noninvasive biomarkers to diagnose early stage HCC." -target gene hsa-mir-26a "Carcinoma, Hepatocellular, HBV-Related" 25814782 "These findings highlight the importance of validating reference genes before quantifying target miRNAs.Furthermore, our findings will improve studies that monitor hepatitis progression and will aid in the discovery of noninvasive biomarkers to diagnose early stage HCC." -target gene hsa-mir-146b Diabetes Mellitus 25815338 MicroRNA-146b-3p regulates retinal inflammation by suppressing adenosine deaminase-2 in diabetes. -target gene hsa-mir-133a "Carcinoma, Gastric" 25815687 "MicroRNA-133a inhibits proliferation and invasion, and induces apoptosis in gastric carcinoma cells via targeting fascin actin-bundling protein 1." -target gene hsa-mir-509 "Carcinoma, Renal Cell" 25815776 MicroRNA-509-3p inhibits cancer cell proliferation and migration by targeting the mitogen-activated protein kinase kinase kinase 8 oncogene in renal cell carcinoma. -target gene hsa-mir-218 "Carcinoma, Hepatocellular" 25816091 MicroRNA-218 and microRNA-520a inhibit cell proliferation by downregulating E2F2 in hepatocellular carcinoma. -target gene hsa-mir-520a "Carcinoma, Hepatocellular" 25816091 MicroRNA-218 and microRNA-520a inhibit cell proliferation by downregulating E2F2 in hepatocellular carcinoma. -target gene hsa-let-7g Follicular Atresia 25817543 let-7g regulates the apoptosis of GCs in the pig ovary by targeting TGFBR1 and down-regulating the TGF-β signaling pathway. -target gene hsa-mir-93 Intervertebral Disc Degeneration 25818544 "Taken together, we demonstrated that miR-93 contributed to abnormal NP cell type II collagen expression by targeting MMP3, involved in intervertebral disc degeneration." -target gene hsa-mir-709 "Carcinoma, Hepatocellular" 25818666 These results suggest that miR-709 may positively regulate invasion and metastasis of HCC through targeting GPC5. -target gene hsa-mir-449a Lung Neoplasms 25818739 "Our data indicate that miR-449a may function as a suppressor of lung cancer, and affects the expression of NEAT1 in lung cancer cells." -target gene hsa-mir-200a Colorectal Carcinoma 25818799 "miR-200a plays a role in regulating the invasiveness and metastasis of CRC, and overexpression of miR-200a causes a significant reduction of cell proliferation and migration and promotes apoptosis and cell-cell adhesion in LoVo cells." -target gene hsa-mir-490 Ovary Mixed Epithelial Carcinoma 25819031 MicroRNA-490-3P targets CDK1 and inhibits ovarian epithelial carcinoma tumorigenesis and progression. -target gene hsa-mir-191 Endometriosis 25819812 "miR-191 can directly regulate TIMP3 expression, thereby affecting cell proliferation rate and invasion ability. The miR-191-TIMP3 axis might be critical in the malignant transformation of endometriosis to EAOC." -target gene hsa-mir-494 "Carcinoma, Hepatocellular" 25820676 MicroRNA-494 is a master epigenetic regulator of multiple invasion-suppressor microRNAs by targeting ten eleven translocation 1 in invasive human hepatocellular carcinoma tumors. -target gene hsa-mir-195 Osteosarcoma 25823925 MicroRNA profiling identifies MiR-195 suppresses osteosarcoma cell metastasis by targeting CCND1. -target gene hsa-mir-155 "Squamous Cell Carcinoma, Esophageal" 25823933 "a novel pattern of differential miRNA-target expression was constructed, which with further investigation, may provide novel targets for diagnosing and understanding the mechanism of ESCC." -target gene hsa-mir-202 "Squamous Cell Carcinoma, Esophageal" 25823933 "a novel pattern of differential miRNA-target expression was constructed, which with further investigation, may provide novel targets for diagnosing and understanding the mechanism of ESCC." -target gene hsa-mir-107 "Adenocarcinoma, Gastric" 25824045 miR-107 and miR-25 simultaneously target LATS2 and regulate proliferation and invasion of gastric adenocarcinoma (GAC) cells. -target gene hsa-mir-25 "Adenocarcinoma, Gastric" 25824045 miR-107 and miR-25 simultaneously target LATS2 and regulate proliferation and invasion of gastric adenocarcinoma (GAC) cells. -target gene hsa-mir-520b "Carcinoma, Hepatocellular" 25824049 MiR-520b suppresses proliferation of hepatoma cells through targeting ten-eleven translocation 1 (TET1) mRNA. -target gene hsa-mir-146b Inflammation 25824148 "Ang-1 disrupts TLR4 signalling, resulting in inhibition of LPS-induced inflammatory responses in endothelial cells. This inhibition occurs through selective targeting of IRAK1 and TRAF6 proteins by miR-146b-5p." -target gene hsa-mir-454 Colorectal Carcinoma 25824771 MiR-454 prompts cell proliferation of human colorectal cancer cells by repressing CYLD expression. -target gene hsa-mir-21 Multiple Myeloma 25825239 "Downregulation of Sprouty homolog 2 by microRNA-21 inhibits proliferation,metastasis and invasion, however promotes the apoptosis of multiple myeloma cells." -target gene hsa-mir-34a Breast Neoplasms 25826085 Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness. -target gene hsa-mir-200b Colorectal Carcinoma 25826661 microRNA-200b and microRNA-200c promote colorectal cancer cell proliferation via targeting the reversion-inducing cysteine-rich protein with Kazal motifs. -target gene hsa-mir-200c Colorectal Carcinoma 25826661 microRNA-200b and microRNA-200c promote colorectal cancer cell proliferation via targeting the reversion-inducing cysteine-rich protein with Kazal motifs. -target gene hsa-mir-16 Breast Neoplasms 25830480 MicroRNA-16 modulates HuR regulation of cyclin E1 in breast cancer cells. -target gene hsa-mir-142 Vascular Disease [unspecific] 25832008 this study demonstrates that miR-142-3p is a key regulator of the TGF¦Â-mediated contractile phenotype of VSMCs that acts through inhibiting cell migration through targeting DOCK6. -target gene hsa-mir-193a "Carcinoma, Lung, Non-Small-Cell" 25833338 miR-193a-3p inhibited the metastasis of lung cancer cells by deregulating the expression of tumor-related proteins. These findings may improve the understanding of the molecular mechanisms underlying the metastatic-inhibitory effect of miR-193a-3p on lung cancer cells. -target gene hsa-mir-429 "Adenocarcinoma, Pancreatic Ductal" 25833382 Low level of miR-429 and high level of TBK1 in PDAC promoted PDAC cells growth which might be related to the low survival rate of PDAC patients.MiR-429 play its role in PDAC by targeting TBK1. -target gene hsa-mir-489 "Carcinoma, Lung, Non-Small-Cell" 25833694 Down-regulation of miR-489 contributes into NSCLC cell invasion through targeting SUZ12. -target gene hsa-mir-197 Ovarian Neoplasms 25833695 MiR-197 induces Taxol resistance in human ovarian cancer cells by regulating NLK. -target gene hsa-mir-139 Neoplasms [unspecific] 25833697 miR-139-5p suppresses cancer cell migration and invasion through targeting ZEB1 and ZEB2 in GBM. -target gene hsa-mir-125a "Carcinoma, Lung, Small-Cell" 25833836 Chemotherapy-Regulated microRNA-125-HER2 Pathway as a Novel Therapeutic Target for Trastuzumab-Mediated Cellular Cytotoxicity in Small Cell Lung Cancer. -target gene hsa-mir-195 "Carcinoma, Lung, Non-Small-Cell" 25840419 MiR-195 suppresses non-small cell lung cancer by targeting CHEK1. -target gene hsa-mir-30 Glioma 25840690 miR-30 overexpression promotes glioma stem cells by regulating Jak/STAT3 signaling pathway. -target gene hsa-mir-483 "Squamous Cell Carcinoma, Tongue" 25843291 miR-483-5p determines mitochondrial fission and cisplatin sensitivity in tongue squamous cell carcinoma by targeting FIS1. -target gene hsa-mir-30d "Carcinoma, Lung, Non-Small-Cell" 25843294 MicroRNA-30d-5p inhibits tumour cell proliferation and motility by directly targeting CCNE2 in non-small cell lung cancer. -target gene hsa-mir-21 "Carcinoma, Ovarian" 25845681 "Icariin regulates the proliferation and apoptosis of human ovarian cancer cells through microRNA-21 by targeting PTEN, RECK and Bcl-2." -target gene hsa-mir-34c "Carcinoma, Endometrial" 25846116 "our study demonstrated that miR-34c plays a role of tumor suppressor in HEC-1-B cells, and E2F3 protein may be a target of miR-34c." -target gene hsa-mir-21 "Adenocarcinoma, Pancreatic Ductal" 25846727 "Our results demonstrate that p85¦Á expression is a determinant of chemosensitivity in PDAC. Additionally, we provide novel evidence that miR-21 can influence PI3K-AKT signaling via its direct regulation of p85¦Á. These data provide insight into potential mechanisms for the known relationship between increased p85¦Á expression and improved survival in PDAC." -target gene hsa-mir-506 Gastric Neoplasms 25846731 MicroRNA-506 inhibits gastric cancer proliferation and invasion by directly targeting Yap1. -target gene hsa-mir-4717 Anxiety Disorders 25847876 data indicate that MIR4717 regulates human RGS2 and contributes to the genetic risk towards anxiety-related traits. -target gene hsa-mir-210 Hemoglobin Diseases 25849663 microRNA-210 and raptor are involved in mithramycin-mediated erythroid differentiation of K562 cells and participate to the fine-tuning and control of ¦Ã-globin gene expression in erythroid precursor cells. -target gene hsa-mir-3127 "Carcinoma, Hepatocellular" 25849943 MicroRNA-3127 promotes cell proliferation and tumorigenicity in hepatocellular carcinoma by disrupting of PI3K/AKT negative regulation. -target gene hsa-mir-107 "Carcinoma, Breast, Triple Negative" 25851994 MiR-107 down-regulates SIAH1 expression in human breast cancer cells and silencing of miR-107 inhibits tumor growth in a nude mouse model of triple-negative breast cancer. -target gene hsa-mir-155 Melanoma 25853464 "microRNA-155, induced by interleukin-1?, represses the expression of microphthalmia-associated transcription factor (MITF-M) in melanoma cells." -target gene hsa-mir-199a Glioma 25854175 MicroRNA-199a-3p suppresses glioma cell proliferation by regulating the AKT/mTOR signaling pathway. -target gene hsa-mir-506 "Carcinoma, Nasopharyngeal" 25856555 MiR-506 suppresses tumor proliferation and invasion by targeting FOXQ1 in nasopharyngeal carcinoma. -target gene hsa-mir-192 Hirschsprung Disease 25857602 Nidogen-1 is a common target of microRNAs MiR-192/215 in the pathogenesis of Hirschsprung's disease. -target gene hsa-mir-215 Hirschsprung Disease 25857602 Nidogen-1 is a common target of microRNAs MiR-192/215 in the pathogenesis of Hirschsprung's disease. -target gene hsa-mir-200c Ovarian Neoplasms 25860109 "This network included four separate types of interactions among miRNAs and genes. Simply analyzing each interaction component in isolation, such as the eQTL associations, the miRNA-target interactions or the protein-protein interactions, would create a much more limited network than the integrated one." -target gene hsa-mir-22 Ovarian Neoplasms 25860109 "This network included four separate types of interactions among miRNAs and genes. Simply analyzing each interaction component in isolation, such as the eQTL associations, the miRNA-target interactions or the protein-protein interactions, would create a much more limited network than the integrated one." -target gene hsa-mir-124 "Carcinoma, Renal Cell" 25861751 miR-124 represses FZD5 to attenuate P-glycoprotein-mediated chemo-resistance in renal cell carcinoma. -target gene hsa-mir-492 "Carcinoma, Colon" 25862460 MiR-492 is functionally involved in Oxaliplatin resistance in colon cancer cells LS174T via its regulating the expression of CD147. -target gene hsa-mir-7 "Carcinoma, Ovarian" 25862909 "There is a link between miR-7 expression and TP53 status and tumour grade in serous OC. Molecular mechanisms of these relationships need to be elucidated. Of the two postulated miR-7 target genes we examined, BCL2, but not EGFR, seems to be a possible miR-7 target in OC." -target gene hsa-mir-375 Neuroblastoma 25864587 Targeting MYCN IRES in MYCN-amplified neuroblastoma with miR-375 inhibits tumor growth and sensitizes tumor cells to radiation. -target gene hsa-mir-221 Inflammation 25865302 these results indicated that miR-221 targets AdipoR1 to regulate endothelial inflammatory response. -target gene hsa-mir-186 Ovarian Neoplasms 25867064 miR-186 regulation of Twist1 and ovarian cancer sensitivity to cisplatin. -target gene hsa-mir-133 "Adenocarcinoma, Lung" 25868726 Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) regulates serum response factor through miR-133 as a competing endogenous RNA in myogenesis. -target gene hsa-mir-33b Melanoma 25868853 "Cordycepin (3'-deoxyadenosine) suppressed HMGA2, Twist1 and ZEB1-dependent melanoma invasion and metastasis by targeting miR-33b." -target gene hsa-mir-217 Gastric Neoplasms 25869101 microRNA-217 inhibits tumor progression and metastasis by downregulating EZH2 and predicts favorable prognosis in gastric cancer. -target gene hsa-mir-155 Down Syndrome 25869329 These results suggest that regulation of TFAM by hsa-miR-155-5p impacts mitochondrial biogenesis in the diploid setting but not in the DS setting. -target gene hsa-mir-124 Lung Neoplasms 25869366 "Novel potential regulatory miRNAs for RHOA (miR-9-1/-3, -34b/c, -129-2, -125b-1, -375, -1258) and NKIRAS1 (miR-34b/c, -129-2, -125b-1, -193a, -124a-1/-2/-3, -212, -132) genes in lung cancer were identified." -target gene hsa-mir-1258 Lung Neoplasms 25869366 "Novel potential regulatory miRNAs for RHOA (miR-9-1/-3, -34b/c, -129-2, -125b-1, -375, -1258) and NKIRAS1 (miR-34b/c, -129-2, -125b-1, -193a, -124a-1/-2/-3, -212, -132) genes in lung cancer were identified." -target gene hsa-mir-129 Lung Neoplasms 25869366 "Novel potential regulatory miRNAs for RHOA (miR-9-1/-3, -34b/c, -129-2, -125b-1, -375, -1258) and NKIRAS1 (miR-34b/c, -129-2, -125b-1, -193a, -124a-1/-2/-3, -212, -132) genes in lung cancer were identified." -target gene hsa-mir-132 Lung Neoplasms 25869366 "Novel potential regulatory miRNAs for RHOA (miR-9-1/-3, -34b/c, -129-2, -125b-1, -375, -1258) and NKIRAS1 (miR-34b/c, -129-2, -125b-1, -193a, -124a-1/-2/-3, -212, -132) genes in lung cancer were identified." -target gene hsa-mir-193a Lung Neoplasms 25869366 "Novel potential regulatory miRNAs for RHOA (miR-9-1/-3, -34b/c, -129-2, -125b-1, -375, -1258) and NKIRAS1 (miR-34b/c, -129-2, -125b-1, -193a, -124a-1/-2/-3, -212, -132) genes in lung cancer were identified." -target gene hsa-mir-212 Lung Neoplasms 25869366 "Novel potential regulatory miRNAs for RHOA (miR-9-1/-3, -34b/c, -129-2, -125b-1, -375, -1258) and NKIRAS1 (miR-34b/c, -129-2, -125b-1, -193a, -124a-1/-2/-3, -212, -132) genes in lung cancer were identified." -target gene hsa-mir-34b Lung Neoplasms 25869366 "Novel potential regulatory miRNAs for RHOA (miR-9-1/-3, -34b/c, -129-2, -125b-1, -375, -1258) and NKIRAS1 (miR-34b/c, -129-2, -125b-1, -193a, -124a-1/-2/-3, -212, -132) genes in lung cancer were identified." -target gene hsa-mir-34c Lung Neoplasms 25869366 "Novel potential regulatory miRNAs for RHOA (miR-9-1/-3, -34b/c, -129-2, -125b-1, -375, -1258) and NKIRAS1 (miR-34b/c, -129-2, -125b-1, -193a, -124a-1/-2/-3, -212, -132) genes in lung cancer were identified." -target gene hsa-mir-375 Lung Neoplasms 25869366 "Novel potential regulatory miRNAs for RHOA (miR-9-1/-3, -34b/c, -129-2, -125b-1, -375, -1258) and NKIRAS1 (miR-34b/c, -129-2, -125b-1, -193a, -124a-1/-2/-3, -212, -132) genes in lung cancer were identified." -target gene hsa-mir-9 Lung Neoplasms 25869366 "Novel potential regulatory miRNAs for RHOA (miR-9-1/-3, -34b/c, -129-2, -125b-1, -375, -1258) and NKIRAS1 (miR-34b/c, -129-2, -125b-1, -193a, -124a-1/-2/-3, -212, -132) genes in lung cancer were identified." -target gene hsa-mir-183 Graves Disease 25871842 Our study highlights the possibility that miRNA-target gene network may be involved in the pathogenesis of GD and could provide new insights into understanding the pathophysiological mechanisms of GD. -target gene hsa-mir-197 Graves Disease 25871842 Our study highlights the possibility that miRNA-target gene network may be involved in the pathogenesis of GD and could provide new insights into understanding the pathophysiological mechanisms of GD. -target gene hsa-mir-22 Graves Disease 25871842 Our study highlights the possibility that miRNA-target gene network may be involved in the pathogenesis of GD and could provide new insights into understanding the pathophysiological mechanisms of GD. -target gene hsa-mir-660 Graves Disease 25871842 Our study highlights the possibility that miRNA-target gene network may be involved in the pathogenesis of GD and could provide new insights into understanding the pathophysiological mechanisms of GD. -target gene hsa-mir-203 Oral Submucous Fibrosis 25872484 "Thus, we provide evidence to illustrate that miR-203 plays a role in the pathogenesis of OSF, which may be a target for OSF management." -target gene hsa-mir-181b Retinoblastoma 25872572 Hypoxia-induced miR-181b enhances angiogenesis of retinoblastoma cells by targeting PDCD10 and GATA6. -target gene hsa-mir-494 "Carcinoma, Colon" 25873402 MicroRNA-494 sensitizes colon cancer cells to fluorouracil through regulation of DPYD. -target gene hsa-mir-15a "Carcinoma, Lung, Non-Small-Cell" 25874488 MicroRNA-15a induces cell apoptosis and inhibits metastasis by targeting BCL2L2 in non-small cell lung cancer. -target gene hsa-mir-1 Gastric Neoplasms 25874496 MicroRNA-1 (miR-1) inhibits gastric cancer cell proliferation and migration by targeting MET. -target gene hsa-mir-10b "Carcinoma, Laryngeal" 25875782 MicroRNA-10b Triggers the Epithelial-Mesenchymal Transition (EMT) of Laryngeal Carcinoma Hep-2 Cells by Directly Targeting the E-cadherin. -target gene hsa-mir-200b Glioma 25877314 miR-200b may suppress cell invasion by targeting PROM1 in glioma. -target gene hsa-mir-34a Bladder Neoplasms 25878394 miR-34a inhibits proliferation and invasion of bladder cancer cells by targeting orphan nuclear receptor HNF4G. -target gene hsa-mir-33a Osteoarthritis 25880168 "Our findings suggest, for the first time to our knowledge, that miR-33a regulates cholesterol synthesis through the TGF-¦Â1/Akt/SREBP-2 pathway,as well as cholesterol efflux-related genes ABCA1 and ApoA1, in OA chondrocytes, pointing to its identification as a novel target for ameliorating the OA phenotype." -target gene hsa-mir-372 "Carcinoma, Hepatocellular" 25880458 miR-372 may play an important role in hepatic carcinogenesis and may serve as a new target or method to detect and treat HCC in the future. -target gene hsa-mir-7 Lung Neoplasms 25880778 KCNJ2/Kir2.1 modulates cell growth and drug resistance by regulating MRP1/ABCC1 expression and is simultaneously regulated by the Ras/MAPK pathway and miR-7. KCNJ2/Kir2.1 may be a prognostic predictor and a potentially novel target for interfering with chemoresistance in SCLC. -target gene hsa-mir-223 Lung Neoplasms 25881295 Our study demonstrates for the first time that platelet-secreted miR-223 via P-MVs can promote lung cancer cell invasion via targeting tumor suppressor EPB41L3. -target gene hsa-mir-221 Pancreatic Neoplasms 25883224 miR-221/222 induces pancreatic cancer progression through the regulation of matrix metalloproteinases. -target gene hsa-mir-222 Pancreatic Neoplasms 25883224 miR-221/222 induces pancreatic cancer progression through the regulation of matrix metalloproteinases. -target gene hsa-mir-200b Diabetes Mellitus 25884496 Polycomb repressive complex 2 regulates MiR-200b in retinal endothelial cells:potential relevance in diabetic retinopathy. -target gene hsa-mir-132 Autism Spectrum Disorder 25885346 We found that through p-CREB/miR-132 signaling cascade is involved in MeCP2-mediated pain transduction. -target gene hsa-mir-200 Breast Neoplasms 25886595 "The ADAM12-L 3'UTR is a direct target of miR-29 and miR-200 family members. Since the miR-29 and miR-200 families play important roles in breast cancer progression, these results may help explain the different prognostic and chemopredictive values of ADAM12-L and ADAM12-S in breast cancer." -target gene hsa-mir-29 Breast Neoplasms 25886595 "The ADAM12-L 3'UTR is a direct target of miR-29 and miR-200 family members. Since the miR-29 and miR-200 families play important roles in breast cancer progression, these results may help explain the different prognostic and chemopredictive values of ADAM12-L and ADAM12-S in breast cancer." -target gene hsa-mir-126 Obesity 25887648 We identified 23 active miRNA-TF-gene regulatory pathways that were significantly related to obesity-related inflammation. -target gene hsa-mir-145 Obesity 25887648 We identified 23 active miRNA-TF-gene regulatory pathways that were significantly related to obesity-related inflammation. -target gene hsa-mir-193b Obesity 25887648 We identified 23 active miRNA-TF-gene regulatory pathways that were significantly related to obesity-related inflammation. -target gene hsa-mir-21 Obesity 25887648 We identified 23 active miRNA-TF-gene regulatory pathways that were significantly related to obesity-related inflammation. -target gene hsa-mir-29b Obesity 25887648 We identified 23 active miRNA-TF-gene regulatory pathways that were significantly related to obesity-related inflammation. -target gene hsa-mir-223 "Carcinoma, Gastric" 25888377 Our findings revealed the roles of miR-223/FBXW7 signaling in the DDP resistance of GC cells and targeting it will be a potential strategic approach for reversing the DDP resistance in human GC. -target gene hsa-mir-29c "Carcinoma, Hepatocellular" 25888625 A suppressive role of ionizing radiation-responsive miR-29c in the development of liver carcinoma via targeting WIP1. -target gene hsa-mir-211 "Carcinoma, Hepatocellular" 25888635 miR-211 suppresses hepatocellular carcinoma by downregulating SATB2. -target gene hsa-mir-135a "Carcinoma, Bladder" 25888950 "Our study demonstrates that miR-135a promotes cell proliferation in bladder cancer by targeting PHLPP2 and FOXO1, and is performed as an onco-miR." -target gene hsa-mir-31 Breast Neoplasms 25889182 These data provide strong evidence that GNA13 expression in breast cancer cells is regulated by post-transcriptional mechanisms involving miR-31.Additionally our data shows that miR-31 regulates breast cancer cell invasion partially via targeting GNA13 expression in breast cancer cells. Loss of miR-31 expression and increased GNA13 expression could be used as biomarkers of breast cancer progression. -target gene hsa-mir-196b Neoplasms [unspecific] 25889892 we identified IGF2BP1 as a direct and functional target of miR-196b and showed that miR-196b overexpression reverses the chemoresistance induced by hypoxia. These results emphasize that the chemoresistance induced by hypoxia is a complex mechanism. -target gene hsa-mir-203 Kidney Neoplasms 25890121 Our study suggested that miR-203 could be a potential prognostic marker and functions as a tumor suppressor in human renal cancer by post-transcriptionally targeting FGF2. -target gene hsa-mir-21 Prostate Neoplasms 25890570 Androgen receptor and microRNA-21 axis downregulates transforming growth factor beta receptor II (TGFBR2) expression in prostate cancer. -target gene hsa-mir-9 "Carcinoma, Nasopharyngeal" 25891118 "These data demonstrated that miR-9 did not modulate the sensitivity of the CNE2 cells to UV radiation through E-cadherin, but suggested that miR-9 regulated radiosensitivity through its effects on glutathione. These findings suggest that miR-9 may be a potential target for modulating the radiosensitivity of NPC cells." -target gene hsa-mir-155 Inflammation 25892184 "miR-155-dependent regulation of mammalian sterile 20-like kinase 2 (MST2) coordinates inflammation, oxidative stress and proliferation in vascular smooth muscle cells." -target gene hsa-mir-93 "Carcinoma, Nasopharyngeal" 25892549 MicroRNA-93 promotes cell growth and invasion in nasopharyngeal carcinoma by targeting disabled homolog-2. -target gene hsa-mir-572 "Carcinoma, Ovarian" 25893382 Upregulation of miR-572 transcriptionally suppresses SOCS1 and p21 and contributes to human ovarian cancer progression. -target gene hsa-mir-4717 Hepatitis B Virus Infection 25895129 microRNA-4717 differentially interacts with its polymorphic target in the PD1 3' untranslated region: A mechanism for regulating PD-1 expression and function in HBV-associated liver diseases. -target gene hsa-mir-34a Ovarian Neoplasms 25895459 MiR-34a suppresses ovarian cancer proliferation and motility by targeting AXL. -target gene hsa-mir-342 Obesity 25895816 "miR-342-3p is a powerful enhancer of the adipogenesis of human adipose-derived MSCs that acts by inhibiting CtBP2 and releasing the key adipogenic regulator C/EBP¦Á from CtBP2 binding, subsequently activating the expression of adipogenic transcription factors and markers." -target gene hsa-mir-141 "Carcinoma, Hepatocellular" 25896253 "Our study showed that miR-141 plays a key role in 5-FU resistance by down-regulating Keap1 expression, thereby reactivating the Nrf2-dependent antioxidant pathway, which may serve as a potential target for overcoming 5-FU resistance in hepatocellular carcinoma cells." -target gene hsa-mir-21 Cardiovascular Diseases [unspecific] 25898844 "In cardiac fibrosis related to Ang II, miR-21 is transcriptionally activated and targets PTEN/SMAD7 resulting in increased fibroblast survival. OPN KO animals are protected from miR-21 increase and fibrosis development due to impaired AP-1 activation and fibroblast activation." -target gene hsa-mir-218 Breast Neoplasms 25900794 miR-218 targets survivin and regulates resistance to chemotherapeutics in breast cancer. -target gene hsa-mir-320 Glioma 25901521 MicroRNA-320 inhibits cell proliferation in glioma by targeting E2F1. -target gene hsa-mir-15b Glioma 25901555 Mangiferin regulates proliferation and apoptosis in glioma cells by induction of microRNA-15b and inhibition of MMP-9 expression. -target gene hsa-mir-148a Glioblastoma 25903473 "miR-31 and miR-148a regulate glioma growth by maintaining tumor stem cells and their niche, and providing the tumor a way to activate angiogenesis even in a normoxic environment.This is the first study that demonstrates intratumoral uptake and growth-inhibiting effects of uncomplexed antagomirs in orthotopic glioma." -target gene hsa-mir-31 Glioblastoma 25903473 "miR-31 and miR-148a regulate glioma growth by maintaining tumor stem cells and their niche, and providing the tumor a way to activate angiogenesis even in a normoxic environment.This is the first study that demonstrates intratumoral uptake and growth-inhibiting effects of uncomplexed antagomirs in orthotopic glioma." -target gene hsa-mir-193b Pancreatic Neoplasms 25905463 Deregulation of the MiR-193b-KRAS Axis Contributes to Impaired Cell Growth in Pancreatic Cancer. -target gene hsa-mir-135b Prostate Neoplasms 25907805 "MicroRNA-135b regulates ER¦Á, AR and HIF1AN and affects breast and prostate cancer cell growth." -target gene hsa-mir-144 Neoplasms [unspecific] 25907866 MicroRNA-144 suppresses tumorigenesis and tumor progression of astrocytoma by targeting EZH2. -target gene hsa-mir-218 "Carcinoma, Cervical" 25908215 MicroRNA-218 increases cellular sensitivity to Rapamycin via targeting Rictor in cervical cancer. -target gene hsa-mir-200b "Carcinoma, Hepatocellular" 25909223 MiR-200b/200c/429 subfamily negatively regulates Rho/ROCK signaling pathway to suppress hepatocellular carcinoma metastasis. -target gene hsa-mir-200c "Carcinoma, Hepatocellular" 25909223 MiR-200b/200c/428 subfamily negatively regulates Rho/ROCK signaling pathway to suppress hepatocellular carcinoma metastasis. -target gene hsa-mir-429 "Carcinoma, Hepatocellular" 25909223 MiR-200b/200c/427 subfamily negatively regulates Rho/ROCK signaling pathway to suppress hepatocellular carcinoma metastasis. -target gene hsa-mir-21 "Lymphoma, B-Cell" 25909227 MicroRNA-21 plays an oncogenic role by targeting FOXO1 and activating the PI3K/AKT pathway in diffuse large B-cell lymphoma. -target gene hsa-let-7c "Carcinoma, Hepatocellular" 25909324 MicroRNA let-7c Inhibits Cell Proliferation and Induces Cell Cycle Arrest by Targeting CDC25A in Human Hepatocellular Carcinoma. -target gene hsa-mir-21 "Leukemia, Lymphocytic, Chronic, B-Cell" 25909590 IL-4 Up-Regulates MiR-21 and the MiRNAs Hosted in the CLCN5 Gene in Chronic Lymphocytic Leukemia. -target gene hsa-mir-144 Osteosarcoma 25912304 MicroRNA-144 suppresses osteosarcoma growth and metastasis by targeting ROCK1 and ROCK2. -target gene hsa-mir-129 "Carcinoma, Hepatocellular" 25912876 MicroRNA-129-5p inhibits hepatocellular carcinoma cell metastasis and invasion via targeting ETS1. -target gene hsa-mir-3144 Human Papilloma Virus Infection 25913515 Two less common human microRNAs miR-875 and miR-3144 target a conserved site of E6 oncogene in most high-risk human papillomavirus subtypes. -target gene hsa-mir-875 Human Papilloma Virus Infection 25913515 Two less common human microRNAs miR-875 and miR-3144 target a conserved site of E6 oncogene in most high-risk human papillomavirus subtypes. -target gene hsa-mir-145 Colorectal Carcinoma 25913620 Tumor suppressor miR-145 reverses drug resistance by directly targeting DNA damage-related gene RAD18 in colorectal cancer. -target gene hsa-mir-185 Hepatitis C Virus Infection 25914460 HCV core protein disturbs the cholesterol homeostasis in HepG2 cells via the SREBP2 pathway; miR-185-5p is involved in the regulation of SREBP2 by the core protein. -target gene hsa-mir-451 Multiple Myeloma 25915427 MicroRNA-451 regulates stemness of side population cells via PI3K/Akt/mTOR signaling pathway in multiple myeloma. -target gene hsa-mir-33b Breast Neoplasms 25919570 "MicroRNA-33b Inhibits Breast Cancer Metastasis by Targeting HMGA2, SALL4 and Twist1." -target gene hsa-mir-18a Neoplasms [unspecific] 25923049 "this probe can be used for cell-specific intracellular miRNA sensing with a confocal microscope. Using miRNA-18a as a target model, the dynamic changes of its expression level inside living cells can be monitored with the proposed method. This method possesses promising applications in the study of miRNA related bioprocesses and biomedicine." -target gene hsa-mir-144 Gastric Neoplasms 25927670 MicroRNA-144 inhibits the metastasis of gastric cancer by targeting MET expression. -target gene hsa-mir-148b "Carcinoma, Lung, Non-Small-Cell" 25927928 miR-148b reverses cisplatin-resistance in non-small cell cancer cells via negatively regulating DNMT1 expression. -target gene hsa-mir-145 "Carcinoma, Colon" 25928322 "Our current observations suggest that miR-21, miR-145, and their networks play critical roles in regulating CSCs growth and/or differentiation in the colon cancer and progression of chemo-resistance." -target gene hsa-mir-21 "Carcinoma, Colon" 25928322 "Our current observations suggest that miR-21, miR-145, and their networks play critical roles in regulating CSCs growth and/or differentiation in the colon cancer and progression of chemo-resistance." -target gene hsa-mir-124 "Carcinoma, Esophageal" 25928665 "Collectively, these data suggest that miR-124 functions as a tumor suppressor in esophageal cancer through, at least partially, targeting STAT3 signaling pathway." -target gene hsa-mir-23a Colorectal Carcinoma 25929864 Elevated microRNA-23a Expression Enhances the Chemoresistance of Colorectal Cancer Cells with Microsatellite Instability to 5-Fluorouracil by Directly Targeting ABCF1. -target gene hsa-mir-193a Inflammatory Bowel Diseases 25931122 "These findings suggest that miR-193a-3p regulation of PepT1 mediates the uptake of bacterial products and is a potent mechanism during the colonic inflammation process. Overall, we believe miR-193a-3p may be a potent regulator of colonic PepT1 for maintaining intestinal homeostasis." -target gene hsa-mir-1291 Neoplasms [unspecific] 25934574 Chimeric MicroRNA-1291 Biosynthesized Efficiently in Escherichia coli Is Effective to Reduce Target Gene Expression in Human Carcinoma Cells and Improve Chemosensitivity. -target gene hsa-mir-330 "Carcinoma, Lung, Non-Small-Cell" 25935837 miR-330-3p controls cell proliferation by targeting early growth response 2 in non-small-cell lung cancer. -target gene hsa-mir-383 Glioma 25936342 "MicroRNA-383 expression regulates proliferation, migration, invasion, and apoptosis in human glioma cells." -target gene hsa-mir-135b Glioblastoma 25936394 MicroRNA-135b exerts oncogenic activity in glioblastoma via the inhibition of glycerol kinase 5 expression. -target gene hsa-mir-16 Spinal Cord Injuries 25936407 "A number of microRNAs (e.g. miR210, miR-487b and miR-16) were observed to target cholesterol metabolism-associated DGEs." -target gene hsa-mir-19a Prostate Neoplasms 25936765 MicroRNA-19a regulates proliferation and apoptosis of castration-resistant prostate cancer cells by targeting BTG1. -target gene hsa-mir-145 "Carcinoma, Ovarian" 25937243 Quercetin induces the apoptosis of human ovarian carcinoma cells by upregulating the expression of microRNA-145. -target gene hsa-mir-137 Glioblastoma 25939439 MiR-137 inhibits proliferation and angiogenesis of human glioblastoma cells by targeting EZH2. -target gene hsa-mir-137 Colorectal Carcinoma 25940441 Tumor suppressive microRNA-137 negatively regulates Musashi-1 and colorectal cancer progression. -target gene hsa-mir-25 Gastric Neoplasms 25944166 "MicroRNA-25 promotes gastric cancer proliferation, invasion, and migration by directly targeting F-box and WD-40 Domain Protein 7, FBXW7." -target gene hsa-mir-132 Ischemic Diseases [unspecific] 25945589 The miR-132/212 cluster promotes arteriogenesis by modulating Ras-MAPK signalling via direct targeting of its inhibitors Rasa1 and Spred1. -target gene hsa-mir-212 Ischemic Diseases [unspecific] 25945589 The miR-132/212 cluster promotes arteriogenesis by modulating Ras-MAPK signalling via direct targeting of its inhibitors Rasa1 and Spred1. -target gene hsa-mir-338 Gastric Neoplasms 25945841 MiR-338-3p inhibits epithelial-mesenchymal transition in gastric cancer cells by targeting ZEB2 and MACC1/Met/Akt signaling. -target gene hsa-mir-2278 Leukemia 25953263 Revealing genome-wide mRNA and microRNA expression patterns in leukemic cells highlighted hsa-miR-2278 as a tumor suppressor for regain of chemotherapeutic imatinib response due to targeting STAT5A. -target gene hsa-mir-429 "Carcinoma, Renal Cell" 25953723 These results revealed a tumor suppressive role for miR-429 in renal cell carcinoma through directly targeting BMI1 and E2F3. -target gene hsa-mir-125b Liver Neoplasms 25953743 MicroRNA-125b attenuates epithelial-mesenchymal transitions and targets stem-like liver cancer cells through small mothers against decapentaplegic 2 and 4. -target gene hsa-mir-34a "Squamous Cell Carcinoma, Esophageal" 25954903 miR-34a inhibits the migration and invasion of esophageal squamous cell carcinoma by targeting Yin Yang-1. -target gene hsa-mir-153 Ovarian Neoplasms 25954928 MicroRNA-153 functions as a tumor suppressor by targeting SET7 and ZEB2 in ovarian cancer cells. -target gene hsa-mir-1 "Carcinoma, Endometrial" 25955017 The tumor-suppressive microRNA-1/133a cluster targets PDE7A and inhibits cancer cell migration and invasion in endometrial cancer. -target gene hsa-mir-133a "Carcinoma, Endometrial" 25955017 The tumor-suppressive microRNA-1/133a cluster targets PDE7A and inhibits cancer cell migration and invasion in endometrial cancer. -target gene hsa-mir-494 Breast Neoplasms 25955111 miR-494 suppresses the progression of breast cancer in vitro by targeting CXCR4 through the Wnt/¦Â-catenin signaling pathway. -target gene hsa-mir-139 Pancreatic Neoplasms 25955258 miR-139 and miR-200c regulate pancreatic cancer endothelial cell migration and angiogenesis. -target gene hsa-mir-200c Pancreatic Neoplasms 25955258 miR-139 and miR-200c regulate pancreatic cancer endothelial cell migration and angiogenesis. -target gene hsa-mir-18a Pregnancy Complications [unspecific] 25955393 "The results of the present study suggested that miR-18a expression suppression led to a decrease in JEG-3 cell invasion and an increase in JEG-3 cell apoptosis, by inducing ESR¦Á expression. The present study provides evidence for the involvement of miR-18a in the pathogenesis of pre-eclamptic pregnancies." -target gene hsa-mir-29a Breast Neoplasms 25955714 MicroRNA-29a inhibits cell migration and invasion by targeting Roundabout 1 in breast cancer cells. -target gene hsa-mir-216a "Squamous Cell Carcinoma, Oral" 25955794 MicroRNA-216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eukaryotic translation initiation factor 4B. -target gene hsa-mir-29 Ependymoma 25958202 microRNA network analysis identifies miR-29 cluster as key regulator of LAMA2 in ependymoma. -target gene hsa-mir-25 Glioma 25960208 miR-25 promotes glioma cell proliferation by targeting CDKN1C. -target gene hsa-mir-939 "Carcinoma, Ovarian" 25960217 MiR-939 promotes the proliferation of human ovarian cancer cells by repressing APC2 expression. -target gene hsa-mir-20a Glioblastoma 25960225 miR-20a mediates temozolomide-resistance in glioblastoma cells via negatively regulating LRIG1 expression. -target gene hsa-mir-146b "Carcinoma, Thyroid" 25960292 Inhibition of miR-146b expression increases radioiodine-sensitivity in poorly differential thyroid carcinoma via positively regulating NIS expression. -target gene hsa-mir-1225 Breast Neoplasms 25961594 "our study demonstrates that HIPK2-kinase and the PLCXD1-phospholipase-C are novel targets of miR-193a-5p/miR-210-3p and miR-575/miR-1225-5p, respectively." -target gene hsa-mir-125a Breast Neoplasms 25961594 "our study demonstrates that HIPK2-kinase and the PLCXD1-phospholipase-C are novel targets of miR-193a-5p/miR-210-3p and miR-575/miR-1225-5p, respectively." -target gene hsa-mir-193 Breast Neoplasms 25961594 "our study demonstrates that HIPK2-kinase and the PLCXD1-phospholipase-C are novel targets of miR-193a-5p/miR-210-3p and miR-575/miR-1225-5p, respectively." -target gene hsa-mir-210 Breast Neoplasms 25961594 "our study demonstrates that HIPK2-kinase and the PLCXD1-phospholipase-C are novel targets of miR-193a-5p/miR-210-3p and miR-575/miR-1225-5p, respectively." -target gene hsa-mir-29a Breast Neoplasms 25961594 "our study demonstrates that HIPK2-kinase and the PLCXD1-phospholipase-C are novel targets of miR-193a-5p/miR-210-3p and miR-575/miR-1225-5p, respectively." -target gene hsa-mir-575 Breast Neoplasms 25961594 "our study demonstrates that HIPK2-kinase and the PLCXD1-phospholipase-C are novel targets of miR-193a-5p/miR-210-3p and miR-575/miR-1225-5p, respectively." -target gene hsa-mir-874 Breast Neoplasms 25961594 "our study demonstrates that HIPK2-kinase and the PLCXD1-phospholipase-C are novel targets of miR-193a-5p/miR-210-3p and miR-575/miR-1225-5p, respectively." -target gene hsa-mir-622 Colorectal Carcinoma 25961730 Radiation-induced microRNA-622 causes radioresistance in colorectal cancer cells by down-regulating Rb. -target gene hsa-mir-125a Leukemia 25961914 microRNA-125a (miR-125a) was identified as a miRNA that suppressed WT1 expression via binding to the WT1-3'UTR. -target gene hsa-mir-125a Breast Neoplasms 25962054 MicroRNA-125a influences breast cancer stem cells by targeting leukemia inhibitory factor receptor which regulates the Hippo signaling pathway. -target gene hsa-mir-1973 Lung Neoplasms 25962089 This may open the door for using epigenetic profile/miRNA expression of some cancer cells as resistance markers/targets to improve response of resistant cells to doxorubicin and for the use of combination doxorubicin/epigenetic modifiers to reduce doxorubicin toxicity. -target gene hsa-mir-29b Lung Neoplasms 25962089 This may open the door for using epigenetic profile/miRNA expression of some cancer cells as resistance markers/targets to improve response of resistant cells to doxorubicin and for the use of combination doxorubicin/epigenetic modifiers to reduce doxorubicin toxicity. -target gene hsa-mir-4286 Lung Neoplasms 25962089 This may open the door for using epigenetic profile/miRNA expression of some cancer cells as resistance markers/targets to improve response of resistant cells to doxorubicin and for the use of combination doxorubicin/epigenetic modifiers to reduce doxorubicin toxicity. -target gene hsa-mir-494 Lung Neoplasms 25962089 This may open the door for using epigenetic profile/miRNA expression of some cancer cells as resistance markers/targets to improve response of resistant cells to doxorubicin and for the use of combination doxorubicin/epigenetic modifiers to reduce doxorubicin toxicity. -target gene hsa-mir-128 "Carcinoma, Hepatocellular" 25962360 miR-128-3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients. -target gene hsa-mir-9 "Carcinoma, Breast, Triple Negative" 25963903 Overexpression of Notch signaling via Notch1 intracellular domain in MDA-MB-231 cell line was suppressed by lentiviruses expressing miR-9. -target gene hsa-mir-494 Pancreatic Neoplasms 25965392 "Ectopic expression of miR-494 inhibited the proliferation, invasion and chemoresistance of pancreatic cancer by regulating SIRT1 and c-Myc." -target gene hsa-mir-361 Colorectal Carcinoma 25965817 MiR-361-5p inhibits colorectal and gastric cancer growth and metastasis by targeting staphylococcal nuclease domain containing-1. -target gene hsa-mir-212 "Carcinoma, Hepatocellular" 25965836 MicroRNA-212 suppresses tumor growth of human hepatocellular carcinoma by targeting FOXA1. -target gene hsa-mir-218 Bladder Neoplasms 25967457 "MicroRNA-218 inhibits bladder cancer cell proliferation, migration, and invasion by targeting BMI-1." -target gene hsa-mir-125b Liver Diseases [unspecific] 25968989 "Our data suggest a mechanism for the marked changes in hepatic gene expression between the fetal and pediatric developmental periods, and support a role for these age-dependent miRNAs in regulating drug disposition." -target gene hsa-mir-34a Liver Diseases [unspecific] 25968989 "Our data suggest a mechanism for the marked changes in hepatic gene expression between the fetal and pediatric developmental periods, and support a role for these age-dependent miRNAs in regulating drug disposition." -target gene hsa-mir-448 "Carcinoma, Hepatocellular" 25969175 miR-448 may contribute to the progression of HCC via regulating ROCK2 expression. -target gene hsa-mir-124 Prostate Neoplasms 25969668 overexpression of miR-124 by transient transfection of mimics led to a significant decrease in talin 1 levels. -target gene hsa-mir-187 Prostate Neoplasms 25969992 MiR-187 Targets the Androgen-Regulated Gene ALDH1A3 in Prostate Cancer. -target gene hsa-mir-33a "Carcinoma, Pancreatic" 25971209 MicroRNA-33a-mediated downregulation of Pim-3 kinase expression renders human pancreatic cancer cells sensitivity to gemcitabine. -target gene hsa-mir-155 "Leukemia, Myeloid, Acute" 25971362 Pharmacological targeting of miR-155 via the NEDD8-activating enzyme inhibitor MLN4924 (Pevonedistat) in FLT3-ITD acute myeloid leukemia. -target gene hsa-mir-148a Glioblastoma 25971746 "These findings uncover a plausible mechanism for NF-¦ÊB-sustained TGF-¦Â/Smad activation via miR-148a in glioblastoma, and may suggest a new target for clinical intervention in human cancer." -target gene hsa-let-7g Gastric Neoplasms 25972194 Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes. -target gene hsa-mir-205 Neoplasms [unspecific] 25973003 These results indicate that miR-205 might inhibitor the proliferation of A549 cells by regulating the expression of PTEN. -target gene hsa-mir-145 Colorectal Carcinoma 25973017 MicroRNA-145 suppresses cell migration and invasion by targeting paxillin in human colorectal cancer cells. -target gene hsa-mir-1247 Osteosarcoma 25973030 MiRNA profile of osteosarcoma with CD117 and stro-1 expression: miR-1247 functions as an onco-miRNA by targeting MAP3K9. -target gene hsa-mir-877 "Carcinoma, Hepatocellular" 25973036 Up-regulation of miR-877 induced by paclitaxel inhibits hepatocellular carcinoma cell proliferation though targeting FOXM1. -target gene hsa-mir-126 Liver Cirrhosis 25974152 "Further, miR-126 promoted TNF-a-induced TGF-¦Â1 and collagen I mRNA expression in LX-2 cells. miR-126 may play an important role in hepatic fibrosis by downregulating the expression of I¦ÊB¦Á partly through the NF-¦ÊB signaling pathway." -target gene hsa-mir-141 Gastric Neoplasms 25975736 MicroRNA-141 inhibits migration of gastric cancer by targeting zinc finger E-box-binding homeobox 2. -target gene hsa-mir-24 Osteomyelitis 25976273 "The Role of MicroRNA, miR-24, and Its Target CHI3L1 in Osteomyelitis Caused by Staphylococcus aureus." -target gene hsa-mir-370 "Carcinoma, Lung, Non-Small-Cell" 25976502 MicroRNA-370 inhibits the progression of non-small cell lung cancer by downregulating oncogene TRAF4. -target gene hsa-mir-142 "Carcinoma, Cervical" 25976503 MicroRNA-142-3p inhibits cell proliferation and invasion of cervical cancer cells by targeting FZD7. -target gene hsa-mir-34 Wounds and Injuries [unspecific] 25978377 "our results provide compelling evidence supporting the existence of 106 novel miRNAs and the dynamic expression of miRNAs that extensively targets the TGF-¦Â pathway at different gestational ages in fetal KCs.MiRNAs showing altered expression at different gestational ages in fetal KCs may contribute to scarless wound healing in early- to mid-gestational fetal Keratinocytes (KCs), and thus may be new targets for potential scar prevention and reduction therapies." -target gene hsa-mir-144 Bronchiolitis Obliterans Syndrome 25979625 "miR-144 is a critical regulator of the TGF-¦Â signaling cascade and is over-expressed in lungs with BOS. Therefore, miR-144 is a potential target toward preventing fibrosis leading to BOS after lung transplant." -target gene hsa-mir-514a Melanoma 25980496 miR-514a regulates the tumour suppressor NF1 and modulates BRAFi sensitivity in melanoma. -target gene hsa-mir-194 Inflammation 25984739 We conclude that miR-194 negatively regulates the TLR4 signal pathway which is activated by PA through directly negative TRAF6 expression. -target gene hsa-mir-19a "Carcinoma, Hepatocellular" 25985117 A systematic investigation based on microRNA-mediated gene regulatory network reveals that dysregulation of microRNA-19a/Cyclin D1 axis confers an oncogenic potential and a worse prognosis in human hepatocellular carcinoma. -target gene hsa-mir-200 "Diabetes Mellitus, Type 2" 25985365 The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes. -target gene hsa-mir-125b Myeloma 25987254 Selective targeting of IRF4 by synthetic microRNA-125b-5p mimics induces anti-multiple myeloma activity in vitro and in vivo. -target gene hsa-mir-197 Uterine Leiomyoma 25990270 Upregulation of miR-197 inhibits cell proliferation by directly targeting IGFBP5 in human uterine leiomyoma cells. -target gene hsa-mir-184 "Carcinoma, Lung, Non-Small-Cell" 25990966 MiR-184 as a tumor suppressor miR inhibits cell proliferation and invasion capability via targeting CDC25A and c-Myc. Low miR-184 level may predict worse prognosis in NSCLC patients. -target gene hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 25990966 MiR-184 as a tumor suppressor miR inhibits cell proliferation and invasion capability via targeting CDC25A and c-Myc. Low miR-184 level may predict worse prognosis in NSCLC patients. -target gene hsa-mir-409 Colorectal Carcinoma 25991585 MicroRNA-409-3p suppresses colorectal cancer invasion and metastasis partly by targeting GAB1 expression. -target gene hsa-mir-193a Bladder Neoplasms 25991669 The miR-193a-3p-regulated ING5 gene activates the DNA damage response pathway and inhibits multi-chemoresistance in bladder cancer. -target gene hsa-mir-191 Neoplasms [unspecific] 25992613 MiR-191 Regulates Primary Human Fibroblast Proliferation and Directly Targets Multiple Oncogenes. -target gene hsa-mir-100 Alzheimer Disease 25992776 "Referring to the Ingenuity database we could identify a set of AD associated genes that are targeted by these miRNAs. Highly predicted targets included genes involved in the regulation of tau and amyloid pathways in AD like MAPT, BACE1 and mTOR." -target gene hsa-mir-103 Alzheimer Disease 25992776 "Referring to the Ingenuity database we could identify a set of AD associated genes that are targeted by these miRNAs. Highly predicted targets included genes involved in the regulation of tau and amyloid pathways in AD like MAPT, BACE1 and mTOR." -target gene hsa-mir-21 Alzheimer Disease 25992776 "Referring to the Ingenuity database we could identify a set of AD associated genes that are targeted by these miRNAs. Highly predicted targets included genes involved in the regulation of tau and amyloid pathways in AD like MAPT, BACE1 and mTOR." -target gene hsa-mir-219 Alzheimer Disease 25992776 "Referring to the Ingenuity database we could identify a set of AD associated genes that are targeted by these miRNAs. Highly predicted targets included genes involved in the regulation of tau and amyloid pathways in AD like MAPT, BACE1 and mTOR." -target gene hsa-mir-296 Alzheimer Disease 25992776 "Referring to the Ingenuity database we could identify a set of AD associated genes that are targeted by these miRNAs. Highly predicted targets included genes involved in the regulation of tau and amyloid pathways in AD like MAPT, BACE1 and mTOR." -target gene hsa-mir-3622b Alzheimer Disease 25992776 "Referring to the Ingenuity database we could identify a set of AD associated genes that are targeted by these miRNAs. Highly predicted targets included genes involved in the regulation of tau and amyloid pathways in AD like MAPT, BACE1 and mTOR." -target gene hsa-mir-375 Alzheimer Disease 25992776 "Referring to the Ingenuity database we could identify a set of AD associated genes that are targeted by these miRNAs. Highly predicted targets included genes involved in the regulation of tau and amyloid pathways in AD like MAPT, BACE1 and mTOR." -target gene hsa-mir-4467 Alzheimer Disease 25992776 "Referring to the Ingenuity database we could identify a set of AD associated genes that are targeted by these miRNAs. Highly predicted targets included genes involved in the regulation of tau and amyloid pathways in AD like MAPT, BACE1 and mTOR." -target gene hsa-mir-505 Alzheimer Disease 25992776 "Referring to the Ingenuity database we could identify a set of AD associated genes that are targeted by these miRNAs. Highly predicted targets included genes involved in the regulation of tau and amyloid pathways in AD like MAPT, BACE1 and mTOR." -target gene hsa-mir-708 Alzheimer Disease 25992776 "Referring to the Ingenuity database we could identify a set of AD associated genes that are targeted by these miRNAs. Highly predicted targets included genes involved in the regulation of tau and amyloid pathways in AD like MAPT, BACE1 and mTOR." -target gene hsa-mir-766 Alzheimer Disease 25992776 "Referring to the Ingenuity database we could identify a set of AD associated genes that are targeted by these miRNAs. Highly predicted targets included genes involved in the regulation of tau and amyloid pathways in AD like MAPT, BACE1 and mTOR." -target gene hsa-mir-15a "Aortic Aneurysm, Abdominal" 25993295 Our data emphasize the potential of miR-15a-3p and miR-30a-5p as biomarkers of AAA but also as triggers of ATLO evolution. Further investigations will be required to evaluate their targets in order to better understand AAA pathophysiology. -target gene hsa-mir-30a "Aortic Aneurysm, Abdominal" 25993295 Our data emphasize the potential of miR-15a-3p and miR-30a-5p as biomarkers of AAA but also as triggers of ATLO evolution. Further investigations will be required to evaluate their targets in order to better understand AAA pathophysiology. -target gene hsa-mir-489 "Aortic Aneurysm, Abdominal" 25993295 Our data emphasize the potential of miR-15a-3p and miR-30a-5p as biomarkers of AAA but also as triggers of ATLO evolution. Further investigations will be required to evaluate their targets in order to better understand AAA pathophysiology. -target gene hsa-mir-1 Myocardial Infarction 25995211 These experiments revealed the role of inducible cAMP early repressor as a repressor of miR-1 and Ito -target gene hsa-mir-1 Vascular Hypertrophy 25995211 These experiments revealed the role of inducible cAMP early repressor as a repressor of miR-1 and Ito -target gene hsa-mir-23b Gastric Neoplasms 25996293 miR-23b-3p regulates the chemoresistance of gastric cancer cells by targeting ATG12 and HMGB2. -target gene hsa-mir-21 Neoplasms [unspecific] 25997617 Our results suggest that miR-21 may regulate intestinal epithelial tight junction permeability through PTEN/PI3K/Akt signalling pathway. This promotes the feasibility of targeting miR-21 in the clinical to preserve the intestinal barrier. -target gene hsa-mir-148b Liver Neoplasms 25997710 miRNA-148b suppresses hepatic cancer stem cell by targeting neuropilin-1. -target gene hsa-mir-335 Neoplasms [unspecific] 25997740 miR-335 Targets SIAH2 and Confers Sensitivity to Anti-Cancer Drugs by Increasing the Expression of HDAC3. -target gene hsa-mir-29a Gastric Neoplasms 25997819 MicroRNA-29a inhibits cell migration and invasion via targeting Roundabout homolog 1 in gastric cancer cells. -target gene hsa-mir-377 Gastric Neoplasms 25998046 MicroRNA-377 predicts poor clinical outcome of gastric cancer and induces tumorigenesis by targeting multiple tumor-suppressor genes. -target gene hsa-mir-125a "Carcinoma, Lung, Non-Small-Cell" 25998575 "miR-125a-3p targets MTA1 to suppress NSCLC cell proliferation, migration, and invasion." -target gene hsa-mir-204 Osteosarcoma 25998694 "MicroRNA-204 inhibits proliferation, migration, invasion and epithelial-mesenchymal transition in osteosarcoma cells via targeting Sirtuin 1." -target gene hsa-mir-155 "Colitis, Ulcerative" 25998827 MiR-155 modulates the inflammatory phenotype of intestinal myofibroblasts by targeting SOCS1 in ulcerative colitis. -target gene hsa-mir-25 Lung Neoplasms 25998847 miR-25 targets the modulator of apoptosis 1 gene in lung cancer. -target gene hsa-mir-218 "Squamous Cell Carcinoma, Esophageal" 25999024 MicroRNA-218 inhibits the proliferation and metastasis of esophageal squamous cell carcinoma cells by targeting BMI1. -target gene hsa-mir-103 Adenovirus Infection 26000071 miR-103 Regulates Oxidative Stress by Targeting the BCL2/Adenovirus E1B 19kDa Interacting Protein 3 in HUVECs. -target gene hsa-mir-182 "Fatty Liver, Non-Alcoholic" 26001595 E3 ubiquitin protein ligase (FBXW7) as potential targets of miR-182 -target gene hsa-mir-526a Neoplasms [unspecific] 26002288 miR-526a regulates apoptotic cell growth in human carcinoma cells. -target gene hsa-mir-582 "Carcinoma, Hepatocellular" 26002580 miR-582-5p inhibits proliferation of hepatocellular carcinoma by targeting CDK1 and AKT3. -target gene hsa-mir-148a Ovarian Neoplasms 26004124 MicroRNA-148a inhibits the proliferation and promotes the paclitaxel-induced apoptosis of ovarian cancer cells by targeting PDIA3. -target gene hsa-mir-148a Ovarian Neoplasms 26004261 MicroRNA-148a inhibits migration and invasion of ovarian cancer cells via targeting sphingosine-1-phosphate receptor 1. -target gene hsa-mir-300 Osteosarcoma 26010572 Up-Regulation of MiR-300 Promotes Proliferation and Invasion of Osteosarcoma by Targeting BRD7. -target gene hsa-mir-200b Breast Neoplasms 26011542 53BP1 suppresses epithelial-mesenchymal transition by downregulating ZEB1 through microRNA-200b/429 in breast cancer. -target gene hsa-mir-429 Breast Neoplasms 26011542 53BP1 suppresses epithelial-mesenchymal transition by downregulating ZEB1 through microRNA-200b/429 in breast cancer. -target gene hsa-mir-155 Vascular Disease [unspecific] 26012521 "knockdown of miR155 could modulate ROS production, NO generation, apoptosis and function of HBMECs via regulating diverse gene expression, such as caspase-3, ICAM-1 and EGFR/ERK/p38 MAPK and PI3K/Akt pathways." -target gene hsa-mir-218 Glioblastoma 26012781 MiR-218 Inhibited Growth and Metabolism of Human Glioblastoma Cells by Directly Targeting E2F2. -target gene hsa-mir-106b Vascular Disease [unspecific] 26013412 The knowledge of molecular targets that change during the senescence can ultimately contribute to a better understanding and prevention of age-related vascular diseases. -target gene hsa-mir-16 Vascular Disease [unspecific] 26013412 The knowledge of molecular targets that change during the senescence can ultimately contribute to a better understanding and prevention of age-related vascular diseases. -target gene hsa-mir-28 Vascular Disease [unspecific] 26013412 The knowledge of molecular targets that change during the senescence can ultimately contribute to a better understanding and prevention of age-related vascular diseases. -target gene hsa-mir-376a Vascular Disease [unspecific] 26013412 The knowledge of molecular targets that change during the senescence can ultimately contribute to a better understanding and prevention of age-related vascular diseases. -target gene hsa-mir-886 Vascular Disease [unspecific] 26013412 The knowledge of molecular targets that change during the senescence can ultimately contribute to a better understanding and prevention of age-related vascular diseases. -target gene hsa-mir-133 Osteoporosis 26013661 "Estrogen deficiency is associated with miR-133 overexpression.MiR-133 can induce postmenopausal osteoporosis by weakening osteogenic differentiation of hMSCs, at least partly through repressing SLC39A1 expression." -target gene hsa-mir-26b Obesity 26016996 Obesity-associated microRNA-26b regulates the proliferation of human preadipocytes via arrest of the G1/S transition. -target gene hsa-mir-106a Kidney Neoplasms 26018509 miR-106a* inhibits the proliferation of renal carcinoma cells by targeting IRS-2. -target gene hsa-mir-301a Pancreatic Neoplasms 26019136 MiR-301a-3p functions as a novel oncogene in PDAC and the oncogenic activity may involve its inhibition of the target gene SMAD4. -target gene hsa-mir-495 Breast Neoplasms 26020378 Downregulated miR-495 [Corrected] Inhibits the G1-S Phase Transition by Targeting Bmi-1 in Breast Cancer. -target gene hsa-mir-483 Prostate Neoplasms 26020509 "Based on our findings, we suggest that blood-based miRNA expression profiling can be used in the diagnosis and maybe even prognosis of the disease.In the future, miRNA profiling could possibly be used in targeted screening,together with Prostate Specific Antigene (PSA) testing, to identify men with an elevated PrCa risk." -target gene hsa-mir-26a "Carcinoma, Hepatocellular" 26021873 miR-26a expression reduced M-CSF expression and recruitment of macrophages in hepatocellular carcinoma(HCC). -target gene hsa-mir-139 "Carcinoma, Hepatocellular" 26022123 "miR-139-5p inhibits epithelial-mesenchymal transition, migration and invasion of hepatocellular carcinoma cells by targeting ZEB1 and ZEB2." -target gene hsa-mir-101 Rheumatic Heart Diseases 26022377 The present study confirmed that miR-101 targets TLR2 3'UTR and represses TLR2 expression. This work also found an association between down-regulated miR-101 and rheumatic heart disease. -target gene hsa-mir-30a Lung Neoplasms 26025408 MiR-30a suppresses non-small cell lung cancer progression through AKT signaling pathway by targeting IGF1R. -target gene hsa-mir-200 "Carcinoma, Ovarian" 26025631 The miR-200 family differentially regulates sensitivity to paclitaxel and carboplatin in human ovarian carcinoma OVCAR-3 and MES-OV cells. -target gene hsa-mir-150 "Leukemia-Lymphoma, Adult T-Cell" 26025667 STAT1: A Novel Target of miR-150 and miR-223 Is Involved in the Proliferation of HTLV-I-Transformed and ATL Cells. -target gene hsa-mir-223 "Leukemia-Lymphoma, Adult T-Cell" 26025667 STAT1: A Novel Target of miR-150 and miR-223 Is Involved in the Proliferation of HTLV-I-Transformed and ATL Cells. -target gene hsa-mir-199a "Squamous Cell Carcinoma, Skin or Unspecific" 26026896 "These results suggested that miR-199a-5p plays a role in pathogenesis of cSCC via inhibition of invasiveness through regulation of BCAM, FZD6 and DDR1 expression." -target gene hsa-mir-199a Hepatitis C Virus Infection 26027911 Inhibition of microRNA-199a-5p reduces the replication of HCV via regulating the pro-survival pathway. -target gene hsa-let-7 Glioma 26028311 MDM4 regulation by the let-7 miRNA family in the DNA damage response of glioma cells. -target gene hsa-mir-101 Atherosclerosis 26033364 miR-101 promotes intracellular cholesterol retention under inflammatory conditions through suppressing ABCA1 expression and suggests that the miR-101-ABCA1 axis may play an intermediary role in the development of NAFLD and vascular atherosclerosis. -target gene hsa-mir-491 "Carcinoma, Cervical" 26034994 MicroRNA-491-5p suppresses cervical cancer cell growth by targeting hTERT. -target gene hsa-mir-126 "Adenocarcinoma, Lung" 26035298 "These DEGs, and DEG-related histone modifications, TFs and miRNAs may be important in the pathogenesis of lung adenocarcinoma. The present results may indicate directions for the next step in the study of the further elucidation and targeted prevention of lung adenocarcinoma." -target gene hsa-mir-30c-2 "Adenocarcinoma, Lung" 26035298 "These DEGs, and DEG-related histone modifications, TFs and miRNAs may be important in the pathogenesis of lung adenocarcinoma. The present results may indicate directions for the next step in the study of the further elucidation and targeted prevention of lung adenocarcinoma." -target gene hsa-mir-153 "Carcinoma, Hepatocellular" 26035427 miR-153 inhibits epithelial-to-mesenchymal transition in hepatocellular carcinoma by targeting Snail. -target gene hsa-mir-34a Gastric Neoplasms 26035691 Depletion of histone deacetylase 1 inhibits metastatic abilities of gastric cancer cells by regulating the miR-34a/CD44 pathway. -target gene hsa-mir-29a Pancreatic Neoplasms 26036346 Micro-RNAs miR-29a and miR-330-5p function as tumor suppressors by targeting the MUC1 mucin in pancreatic cancer cells. -target gene hsa-mir-330 Pancreatic Neoplasms 26036346 Micro-RNAs miR-29a and miR-330-5p function as tumor suppressors by targeting the MUC1 mucin in pancreatic cancer cells. -target gene hsa-mir-101 "Carcinoma, Breast, Triple Negative" 26036638 MicroRNA-101 inhibits cell progression and increases paclitaxel sensitivity by suppressing MCL-1 expression in human triple-negative breast cancer. -target gene hsa-mir-375 Osteosarcoma 26036761 MicroRNA-375 functions as a tumor suppressor in osteosarcoma by targeting PIK3CA. -target gene hsa-mir-18b "Leukemia, Promyelocytic, Acute" 26041820 PML/RAR¦Á-Regulated miR-181a/b Cluster Targets the Tumor Suppressor RASSF1A in Acute Promyelocytic Leukemia. -target gene hsa-mir-522 "Carcinoma, Colon" 26043974 MicroRNA-522 reverses drug resistance of doxorubicin-induced HT29 colon cancer cell by targeting ABCB5. -target gene hsa-mir-24 Breast Neoplasms 26044523 miRNA-24-3p promotes cell proliferation and inhibits apoptosis in human breast cancer by targeting p27Kip1. -target gene hsa-mir-494 "Carcinoma, Hepatocellular" 26045065 "miR-494 promotes cell proliferation, migration and invasion, and increased sorafenib resistance in hepatocellular carcinoma by targeting PTEN." -target gene hsa-mir-138 Psoriasis 26045321 MicroRNA-138 regulates the balance of Th1/Th2 via targeting RUNX3 in psoriasis. -target gene hsa-mir-98 "Aortic Aneurysm, Abdominal" 26045772 "our data provide compelling evidence on the association between hypoxia and inflammation triggered by hypoxia and then mediated by MCP-1/miR-98/IL-6/p38 regulatory loop, which leads to hASMCs apoptosis via Stat1 activation to contribute to AAA formation and progression." -target gene hsa-mir-570 "Carcinoma, Lung" 26045791 MicroRNA-570 promotes lung carcinoma proliferation through targeting tumor suppressor KLF9. -target gene hsa-mir-503 "Carcinoma, Breast" 26047605 MiR-503 inhibited cell proliferation of human breast cancer cells by suppressing CCND1 expression. -target gene hsa-let-7 "Carcinoma, Cervical" 26051842 "Overall, our study suggests that the microRNAs, miR-21 and let-7a function as clinically relevant integral components of STAT3 signaling and are responsible for maintaining activated state of STAT3 in HPV-infected cells during cervical carcinogenesis." -target gene hsa-mir-206 "Carcinoma, Breast, Triple Negative" 26053033 "Consistent with increased levels of miR-206 in MaCSCs, the expression of both PDCD4 and CX43 was suppressed in these cells relative to control cells." -target gene hsa-mir-106b Giant Cell Tumor of Bone 26053181 MicroRNA-106b inhibits osteoclastogenesis and osteolysis by targeting RANKL in giant cell tumor of bone. -target gene hsa-mir-199a Liver Neoplasms 26054020 MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer. -target gene hsa-mir-498 Ovarian Neoplasms 26054675 MiR-498 regulated FOXO3 expression and inhibited the proliferation of human ovarian cancer cells. -target gene hsa-mir-485 "Carcinoma, Hepatocellular" 26054676 Involvement of miR-485-5p in hepatocellular carcinoma progression targeting EMMPRIN. -target gene hsa-mir-126 Gastric Neoplasms 26054677 MicroRNA-126 inhibits cell proliferation in gastric cancer by targeting LAT-1. -target gene hsa-mir-892a Colorectal Carcinoma 26054685 miR-892a regulated PPP2R2A expression and promoted cell proliferation of human colorectal cancer cells. -target gene hsa-mir-217 Osteosarcoma 26054690 miR-217 targeting Wnt5a in osteosarcoma functions as a potential tumor suppressor. -target gene hsa-mir-197 Colorectal Carcinoma 26055341 miR-197 mediates the response of colorectal cancer cells to 5-FU by regulating TYMS expression. -target gene hsa-mir-99a Thrombocytopenia 26055579 "We believe that miR-99a regulates CTDSPL, which induces the G1/Stransition by increasing Cyclin expression and play a significant role in proliferation of CB-MKs." -target gene hsa-mir-223 "Carcinoma, Nasopharyngeal" 26055874 "MiR-223 negatively regulates the growth and migration of NPC cells via reducing MAFB expression, and this finding provides a novel insight into understanding miR-223 regulation mechanism in nasopharyngeal carcinoma tumorigenesis." -target gene hsa-mir-29a Atherosclerosis 26056009 "our study demonstrates that miR-29a inhibits QKI, which in turn results in upregulation of scavenger receptor A (SRA) and lipid uptake." -target gene hsa-mir-144 Bladder Neoplasms 26057453 miR-144-5p functions as tumour suppressor in BC cells. CCNE1 and CCNE2 were directly regulated by miR-144-5p and might be good prognostic markers for survival of BC patients. -target gene hsa-mir-429 "Carcinoma, Colon" 26058485 MicroRNA-429 inhibits the migration and invasion of colon cancer cells by targeting PAK6/cofilin signaling. -target gene hsa-mir-19a "Carcinoma, Renal Cell" 26058752 Downregulation of miR-19a exhibits inhibitory effects on metastatic renal cell carcinoma by targeting PIK3CA and inactivating Notch signaling in vitro. -target gene hsa-mir-16 "Adenocarcinoma, Lung" 26061016 Quercetin Decreases Claudin-2 Expression Mediated by Up-Regulation of microRNA miR-16 in Lung Adenocarcinoma A549 Cells. -target gene hsa-mir-135b Colorectal Carcinoma 26061281 miR-135b Promotes Cancer Progression by Targeting Transforming Growth Factor Beta Receptor II (TGFBR2) in Colorectal Cancer. -target gene hsa-mir-141 Prostate Neoplasms 26062412 miR-141-3p regulates the expression of androgen receptor by targeting its 3'UTR in prostate cancer LNCaP cells -target gene hsa-mir-221 Bone Disease [unspecific] 26062554 Intercellular adhesion molecule-1 was upregulated by microRNA-221 in mesenchymal stem cells because microRNAs are key regulators of various biological functions via gene expression. -target gene hsa-mir-92a Neoplasms [unspecific] 26062558 An In Vivo Method to Identify microRNA Targets Not Predicted by Computation Algorithms: p21 Targeting by miR-92a in Cancer. -target gene hsa-mir-200b "Carcinoma, Breast, Triple Negative" 26062653 Dual regulation by microRNA-200b-3p and microRNA-200b-5p in the inhibition of epithelial-to-mesenchymal transition in triple-negative breast cancer. -target gene hsa-mir-153 "Adenocarcinoma, Pancreatic Ductal" 26062664 MicroRNA-153 is a prognostic marker and inhibits cell migration and invasion by targeting SNAI1 in human pancreatic ductal adenocarcinoma. -target gene hsa-mir-183 "Carcinoma, Thyroid, Papillary" 26063221 miR-183 regulates biological behavior in papillary thyroid carcinoma by targeting the programmed cell death 4. -target gene hsa-mir-26a Prostate Neoplasms 26063484 MicroRNA-26a/b directly regulate La-related protein 1 and inhibit cancer cell invasion in prostate cancer. -target gene hsa-mir-26b Prostate Neoplasms 26063484 MicroRNA-26a/b directly regulate La-related protein 1 and inhibit cancer cell invasion in prostate cancer. -target gene hsa-mir-141 "Carcinoma, Prostate" 26065649 "The presence of the microRNA-141 target molecules activates the DNA molecular machine powered by the DNA fuel strands, leading to non-enzymatic target cyclic reuse of microRNA-141 and significantly amplified fluorescent signals for sensitive monitoring of microRNA-141 from low numbers of human prostate cancer cells." -target gene hsa-mir-26b Lung Neoplasms 26068649 Down-regulation of microRNA-26b modulates non-small cell lung cancer cells chemoresistance and migration through the association of PTEN. -target gene hsa-mir-145 "Carcinoma, Hepatocellular" 26068913 miR-145 regulates chemoresistance in hepatocellular carcinoma via epithelial mesenchymal transition. -target gene hsa-mir-620 Neoplasms [unspecific] 26068950 miR-620 promotes tumor radioresistance by targeting 15-hydroxyprostaglandin dehydrogenase (HPGD). -target gene hsa-let-7c Moyamoya Disease 26070522 "Increased expression of let-7c in MMD patients may contribute to MMD pathogenesis by targeting RNF213. Thus, let-7c may be a potential biomarker for the diagnosis of MMD." -target gene hsa-mir-125a Melanoma 26071398 "we discovered that Lin28B, a well-characterized inhibitor of let-7 miRNA biogenesis, was a direct target of miR-125a-5p in melanoma." -target gene hsa-mir-365 "Squamous Cell Carcinoma, Skin or Unspecific" 26072217 microRNA-365-targeted nuclear factor I/B transcriptionally represses cyclin-dependent kinase 6 and 4 to inhibit the progression of cutaneous squamous cell carcinoma. -target gene hsa-mir-362 Neuroblastoma 26073258 miR-362-5p inhibits proliferation and migration of neuroblastoma cells by targeting phosphatidylinositol 3-kinase-C2¦Â. -target gene hsa-mir-21 "Adenocarcinoma, Pancreatic Ductal" 26077422 The role of miR-21 and miR-211 on MMP9 regulation in pancreatic ductal adenocarcinoma: cooperation in invasiveness behaviors -target gene hsa-mir-211 "Adenocarcinoma, Pancreatic Ductal" 26077422 The role of miR-21 and miR-211 on MMP9 regulation in pancreatic ductal adenocarcinoma: cooperation in invasiveness behaviors -target gene hsa-mir-34a Cholangiocarcinoma 26077733 microRNA-34a inhibits epithelial mesenchymal transition in human cholangiocarcinoma by targeting Smad4 through transforming growth factor-beta/Smad pathway. -target gene hsa-mir-144 Leukemia 26078353 The long noncoding RNA TUG1 regulates blood-tumor barrier permeability by targeting miR-144. -target gene hsa-mir-200b Neoplasms [unspecific] 26079153 Our results demonstrate that the p53 target miR-200b/200c/429 miRNAs are negative regulators of the CRKL oncogene. -target gene hsa-mir-200c Neoplasms [unspecific] 26079153 Our results demonstrate that the p53 target miR-200b/200c/429 miRNAs are negative regulators of the CRKL oncogene. -target gene hsa-mir-429 Neoplasms [unspecific] 26079153 Our results demonstrate that the p53 target miR-200b/200c/429 miRNAs are negative regulators of the CRKL oncogene. -target gene hsa-mir-199a Osteosarcoma 26079799 CD44 is a direct target of miR-199a-3p and contributes to aggressive progression in osteosarcoma. -target gene hsa-mir-139 Breast Neoplasms 26079880 MicroRNA-139 suppresses proliferation in luminal type breast cancer cells by targeting Topoisomerase II alpha. -target gene hsa-mir-144 Osteosarcoma 26081423 MicroRNA-144 acts as a tumor suppressor by targeting Rho-associated coiled-coil containing protein kinase 1 in osteosarcoma cells. -target gene hsa-mir-219 Glioblastoma 26081620 MicroRNA-219-5p exerts tumor suppressor function by targeting ROBO1 in glioblastoma. -target gene hsa-mir-4649 "Carcinoma, Nasopharyngeal" 26081980 MicroRNA-4649-3p inhibits cell proliferation by targeting protein tyrosine phosphatase SHP-1 in nasopharyngeal carcinoma cells. -target gene hsa-mir-21 Neoplasms [unspecific] 26082192 "we describe the ever-expanding role of miR-21 and its target genes in different cancers, and provide insight into how this oncogenic miRNA regulates cancer cell proliferation, migration, and apoptosis by suppressing the expression of tumor suppressors." -target gene hsa-mir-340 Heart Failure 26084457 microRNA-340-5p Functions Downstream of Cardiotrophin-1 to Regulate Cardiac Eccentric Hypertrophy and Heart Failure via Target Gene Dystrophin. -target gene hsa-mir-107 Glioma 26084601 Upregulation of miR-107 Inhibits Glioma Angiogenesis and VEGF Expression. -target gene hsa-mir-570 "Carcinoma, Hepatocellular" 26084609 MiR-570 inhibited the cell proliferation and invasion through directly targeting B7-H1 in hepatocellular carcinoma. -target gene hsa-mir-15b Myasthenia Gravis 26087886 "This study is the first to report the miR-15b-IL-15 axis can directly regulate IL15 expression, which helps to further explain the abnormal IL-15 expression in MG patients and the pathogenesis of MG." -target gene hsa-mir-26b Rheumatoid Arthritis 26088648 "MiR-26b regulates ¦Â-catenin and CyclinD1 levels by inhibiting GSK-3¦Â expression, which in-turn alters the Wnt/GSK-3¦Â/¦Â-catenin pathway to lower RAFLS proliferation and elevate cell apoptosis and the secretion of TNF-¦Á,IL-1¦Â and IL-6 cytokines. Therefore, our results show that miR-26B plays a central role in inhibiting the inflammation associated with rheumatoid arthritis." -target gene hsa-mir-9 Neoplasms [unspecific] 26091714 our findings have identified a critical role of miR-9 in regulating the differentiation and function of Myeloid-derived suppressor cells (MDSCs). -target gene hsa-mir-206 Breast Neoplasms 26093295 "Overexpression of miR-206 suppresses glycolysis, proliferation and migration in breast cancer cells via PFKFB3 targeting." -target gene hsa-mir-132 Liver Neoplasms 26096363 Hsa-miR-132 inhibits proliferation of hepatic carcinoma cells by targeting YAP. -target gene hsa-mir-29a Neoplasms [unspecific] 26096783 Tumour-suppressive microRNA-29s directly regulate LOXL2 expression and inhibit cancer cell migration and invasion in renal cell carcinoma. -target gene hsa-mir-29b Neoplasms [unspecific] 26096783 Tumour-suppressive microRNA-29s directly regulate LOXL2 expression and inhibit cancer cell migration and invasion in renal cell carcinoma. -target gene hsa-mir-29c Neoplasms [unspecific] 26096783 Tumour-suppressive microRNA-29s directly regulate LOXL2 expression and inhibit cancer cell migration and invasion in renal cell carcinoma. -target gene hsa-mir-34c "Carcinoma, Gastric" 26097561 PABPC1 exerts carcinogenesis in gastric carcinoma by targeting miR-34c. -target gene hsa-mir-106a Lung Neoplasms 26097565 miR-106a promotes growth and metastasis of non-small cell lung cancer by targeting PTEN. -target gene hsa-mir-139 Lung Neoplasms 26097570 Our results indicated that miR-139-5p acts as a tumor suppressor in non-small cell lung cancer (NSCLC) partially via down-regulating IGF1R expression. -target gene hsa-mir-144 Liver Fibrosis 26097586 miR-144 regulates transforming growth factor-¦Â1 iduced hepatic stellate cell activation in human fibrotic liver. -target gene hsa-mir-217 Gastric Neoplasms 26098560 The MicroRNA-217 Functions as a Potential Tumor Suppressor in Gastric Cancer by Targeting GPC5. -target gene hsa-mir-21 Breast Neoplasms 26098771 The LPA1/ZEB1/miR-21-activation pathway regulates metastasis in basal breast cancer. -target gene hsa-mir-34a Liver Diseases [unspecific] 26100857 miR-34a-HNF4¦Á pathway is activated under common conditions of metabolic stress and may have a role in the pathogenesis of Non-alcoholic fatty liver disease(NAFLD) and in regulating plasma lipoprotein metabolism. -target gene hsa-mir-137 "Carcinoma, Gastric" 26102366 MicroRNA-137 Contributes to Dampened Tumorigenesis in Human Gastric Cancer by Targeting AKT2. -target gene hsa-mir-34a Colorectal Carcinoma 26103003 MicroRNA-34a targets FMNL2 and E2F5 and suppresses the progression of colorectal cancer. -target gene hsa-mir-370 Osteoarthritis 26103880 "miR-370 and miR-373 regulate the pathogenesis of osteoarthritis by modulating one-carbon metabolism via SHMT-2 and MECP-2, respectively." -target gene hsa-mir-373 Osteoarthritis 26103880 "miR-370 and miR-373 regulate the pathogenesis of osteoarthritis by modulating one-carbon metabolism via SHMT-2 and MECP-2, respectively." -target gene hsa-mir-448 Ovarian Neoplasms 26103953 "Our data indicate that miR-448 functions as a tumor suppressor in ovarian cancer, which exerts its activity by suppressing the expression of CXCL12." -target gene hsa-mir-9 Melanoma 26104682 These results identify a novel YY1~miR-9~RYBP axis involved in melanoma tumorigenesis and reinforce the idea that regulatory circuitries involving miRNAs and TFs are prevalent mechanisms. -target gene hsa-mir-9 Osteosarcoma 26107195 miR-9 Modulates Osteosarcoma Cell Growth by Targeting the GCIP Tumor Suppressor. -target gene hsa-mir-34b Prostate Neoplasms 26107383 Deregulation of MiR-34b/Sox2 Predicts Prostate Cancer Progression. -target gene hsa-mir-326 "Adenocarcinoma, Lung" 26111641 "Adam17, a Target of Mir-326, Promotes Emt-Induced Cells Invasion in Lung Adenocarcinoma." -target gene hsa-mir-129 "Carcinoma, Hepatocellular" 26116538 miR-129 suppresses tumor cell growth and invasion by targeting PAK5 in hepatocellular carcinoma. -target gene hsa-mir-15a Multiple Myeloma 26117022 "High expression of miR-15a can induce cell cycle arrest and apoptosis of MM cells, then inhibit their growth. The mechanisms may be related with the negative regulation of BMI-1 and BCL-2 genes in post-transcription level caused by miR-15a." -target gene hsa-mir-1 Ovarian Neoplasms 26117268 "The mRNA level of HOTAIR and MAPK1 in ovarian SKOV3 decreased when transected with miR-1, miR-214-3p, or miR-330-5p compared to negative control (p<0.05)." -target gene hsa-mir-19b Atherosclerosis 26117405 "Taken together, these results demonstrate that PGC-1¦Á plays a protective role against the vascular complications of atherosclerosis. Moreover, the posttranscriptional regulation of PGC-1¦Á by miR-19b/221/222 was unveiled,which provides a novel mechanism in which a panel of microRNAs can modulate endothelial cell apoptosis via the regulation mitochondrial function." -target gene hsa-mir-221 Atherosclerosis 26117405 "Taken together, these results demonstrate that PGC-1¦Á plays a protective role against the vascular complications of atherosclerosis. Moreover, the posttranscriptional regulation of PGC-1¦Á by miR-19b/221/222 was unveiled,which provides a novel mechanism in which a panel of microRNAs can modulate endothelial cell apoptosis via the regulation mitochondrial function." -target gene hsa-mir-222 Atherosclerosis 26117405 "Taken together, these results demonstrate that PGC-1¦Á plays a protective role against the vascular complications of atherosclerosis. Moreover, the posttranscriptional regulation of PGC-1¦Á by miR-19b/221/222 was unveiled,which provides a novel mechanism in which a panel of microRNAs can modulate endothelial cell apoptosis via the regulation mitochondrial function." -target gene hsa-mir-193 Liver Fibrosis 26120970 These results suggest that miR-30 and miR-193 are members of a network of miRNAs modifying the TGF-¦Â-dependent regulation of extracellular matrix-related genes in HSCs in the manifestation and resolution of liver fibrosis. -target gene hsa-mir-30 Liver Fibrosis 26120970 These results suggest that miR-30 and miR-193 are members of a network of miRNAs modifying the TGF-¦Â-dependent regulation of extracellular matrix-related genes in HSCs in the manifestation and resolution of liver fibrosis. -target gene hsa-mir-153 Glioma 26124081 MicroRNA-153/Nrf-2/GPx1 pathway regulates radiosensitivity and stemness of glioma stem cells via reactive oxygen species. -target gene hsa-mir-106b Prostate Neoplasms 26124181 miR-93/miR-106b/miR-375-CIC-CRABP1: a novel regulatory axis in prostate cancer progression. -target gene hsa-mir-375 Prostate Neoplasms 26124181 miR-93/miR-106b/miR-375-CIC-CRABP1: a novel regulatory axis in prostate cancer progression. -target gene hsa-mir-93 Prostate Neoplasms 26124181 miR-93/miR-106b/miR-375-CIC-CRABP1: a novel regulatory axis in prostate cancer progression. -target gene hsa-mir-155 "Diabetes Mellitus, Type 2" 26125263 "In type 2 diabetes mellitus (T2DM) retinopathy, miR-155 may play an important role in the pathogenesis of T2DM retinopathy by regulating the Treg cells with TGF-¦Â." -target gene hsa-mir-206 Breast Neoplasms 26125274 Our results suggest hsa-miR-206 may repress the tumor proliferation and invasion in breast cancer by targeting Cx43. -target gene hsa-mir-9 "Carcinoma, Hepatocellular" 26125451 MicroRNA-9-3p was identified as the tumour-suppressor miR targetting TAZ expression in HCC cells. -target gene hsa-mir-410 Pituitary Neoplasms 26125663 Downregulation of miR-410 targeting the cyclin B1 gene plays a role in pituitary gonadotroph tumors. -target gene hsa-let-7 "Carcinoma, Nasopharyngeal" 26125802 The let-7 and miR-29 families may be related to the development of NPC by regulating the genes involved in cell cycle and ECM-receptor interaction. -target gene hsa-mir-29 "Carcinoma, Nasopharyngeal" 26125802 The let-7 and miR-29 families may be related to the development of NPC by regulating the genes involved in cell cycle and ECM-receptor interaction. -target gene hsa-mir-193b Prostate Neoplasms 26129688 Epigenetically altered miR-193b targets cyclin D1 in prostate cancer. -target gene hsa-mir-205 "Carcinoma, Hepatocellular" 26129839 MicroRNA-205 regulates ubiquitin specific peptidase 7 protein expression in hepatocellular carcinoma cells. -target gene hsa-mir-100 Breast Neoplasms 26130569 The role of miR-100 in regulating apoptosis of breast cancer cells. -target gene hsa-mir-130a Gastric Neoplasms 26134263 "miR-130a acts as a potential diagnostic biomarker and promotes gastric cancer migration, invasion and proliferation by targeting RUNX3." -target gene hsa-mir-133a "Carcinoma, Cervical" 26134491 miR-133a inhibits cervical cancer growth by targeting EGFR. -target gene hsa-mir-99b "Carcinoma, Hepatocellular" 26134929 miR-99b promotes metastasis of hepatocellular carcinoma through inhibition of claudin 11 expression and may serve as a prognostic marker. -target gene hsa-mir-7 Lung Neoplasms 26135959 MicroRNA-7 inhibits the malignant phenotypes of non-small cell lung cancer in vitro by targeting Pax6. -target gene hsa-mir-203 Neuroblastoma 26136151 MicroRNA-203 inhibits the malignant progression of neuroblastoma by targeting Sam68. -target gene hsa-mir-196 Neoplasms [unspecific] 26141604 The miR-196 miRNA gene family located within the Hox gene clusters hsa been shown to function during embryogenesis and to be aberrantly expressed in various malignancies -target gene hsa-mir-21 Glioblastoma 26142886 Targeting strategies on miRNA-21 and PDCD4 for glioblastoma. -target gene hsa-mir-216a Pancreatic Neoplasms 26149212 miR-216a may inhibit pancreatic tumor growth by targeting JAK2. -target gene hsa-mir-410 Lung Neoplasms 26149213 MicroRNA-410 promotes cell proliferation by targeting BRD7 in non-small cell lung cancer. -target gene hsa-mir-1283 Hypertension 26149214 inhibition of miR-1283 in HA-VSMCs enhanced the expression of Activating transcription factor 1 mRNA as well as the ROS levels. -target gene hsa-mir-9 Bladder Neoplasms 26150338 miR-9 promotes cell proliferation and inhibits apoptosis by targeting LASS2 in bladder cancer. -target gene hsa-mir-221 Epstein-Barr Virus Infection 26153983 Epstein-Barr Virus Proteins EBNA3A and EBNA3C Together Induce Expression of the Oncogenic MicroRNA Cluster miR-221/miR-222 and Ablate Expression of Its Target p57KIP2. ebv-miR-BART20-5p -target gene hsa-mir-222 Epstein-Barr Virus Infection 26153983 Epstein-Barr Virus Proteins EBNA3A and EBNA3C Together Induce Expression of the Oncogenic MicroRNA Cluster miR-221/miR-222 and Ablate Expression of Its Target p57KIP2. ebv-miR-BART20-5p -target gene hsa-mir-29b Glioblastoma 26155940 miR-29b attenuates tumorigenicity and stemness maintenance in human glioblastoma multiforme by directly targeting BCL2L2. -target gene hsa-mir-133a "Carcinoma, Hepatocellular" 26156803 MicroRNA-133a functions as a tumor suppressor by targeting IGF-1R in hepatocellular carcinoma. -target gene hsa-mir-612 Colorectal Carcinoma 26158514 miR-612 negatively regulates colorectal cancer growth and metastasis by targeting AKT2. -target gene hsa-mir-101 "Carcinoma, Hepatocellular" 26158762 MiR-101 targets DUSP1 to regulate the TGF-¦Â secretion in sorafenib inhibits macrophage-induced growth of hepatocarcinoma. -target gene hsa-mir-17 Melanoma 26158900 miR-17 regulates melanoma cell motility by inhibiting the translation of ETV1. -target gene hsa-mir-155 Atherosclerosis 26159489 microRNA-155 works as a promoter in the atherosclerotic procession. Its mechanism may include enhancing inflammatory response in atherosclerosis by increasing STAT3 and NF-¦ÊB signaling via targeting SOCS1. -target gene hsa-mir-1271 Gastric Neoplasms 26159618 "MiR-1271 Inhibits Cell Proliferation, Invasion and EMT in Gastric Cancer by Targeting FOXQ1." -target gene hsa-mir-499 "Carcinoma, Esophageal" 26159783 MiR-499 Enhances the Cisplatin Sensitivity of Esophageal Carcinoma Cell Lines by Targeting DNA Polymerase ¦Â. -target gene hsa-mir-141 Gastric Neoplasms 26160158 "These results were the first to demonstrate that H19 and miR-141 could compete with each other and affect their target genes in gastric cancer,which provide important clues for understanding the key roles of lncRNA-miRNA functional network in cancer." -target gene hsa-mir-495 Medulloblastoma 26160158 Our results suggest that miR-495 may be a prognostic predictor in medulloblastoma and that Gfi1 is a potential functional target of miR-495. -target gene hsa-mir-28 "Carcinoma, Hepatocellular" 26160280 Down-regulated miR-28-5p in human hepatocellular carcinoma correlated with tumor proliferation and migration by targeting insulin-like growth factor-1 (IGF-1). -target gene hsa-mir-1275 "Carcinoma, Hepatocellular" 26160756 miR-1275: A single microRNA that targets the three IGF2-mRNA-binding proteins hindering tumor growth in hepatocellular carcinoma. -target gene hsa-mir-503 "Carcinoma, Hepatocellular" 26163260 miR-503 suppresses metastasis of hepatocellular carcinoma cell by targeting PRMT1. -target gene hsa-mir-137 Schizophrenia 26163462 Experimental validation of candidate schizophrenia gene CALN1 as a target for microRNA-137. -target gene hsa-mir-99a "Carcinoma, Thyroid, Anaplastic" 26163618 MiR-99a Inhibits Cell Proliferation and Tumorigenesis through Targeting mTOR in Human Anaplastic Thyroid Cancer. -target gene hsa-mir-27a Glioma 26164457 MiR-27a regulates Wnt/beta-catenin signaling through targeting SFRP1 in glioma. -target gene hsa-mir-95 Glioma 26165303 "Downregulation of miR-95-3p inhibits proliferation, and invasion promoting apoptosis of glioma cells by targeting CELF2." -target gene hsa-mir-20a Kidney Injury 26165754 MiR-20a-5p mediates hypoxia-induced autophagy by targeting ATG16L1 in ischemic kidney injury. -target gene hsa-mir-20b Bladder Neoplasms 26166554 "MicroRNA-20b inhibits the proliferation, migration and invasion of bladder cancer EJ cells via the targeting of cell cycle regulation and Sp-1-mediated MMP-2 expression." -target gene hsa-mir-134 Lung Neoplasms 26166818 MicroRNA-134 regulates lung cancer cell H69 growth and apoptosis by targeting WWOX gene and suppressing the ERK1/2 signaling pathway. -target gene hsa-mir-208 "Carcinoma, Hepatocellular" 26169693 miR-208-3p promotes hepatocellular carcinoma cell proliferation and invasion through regulating ARID2 expression. -target gene hsa-mir-144 Neoplasms [unspecific] 26169798 Our approach provides important insights into miRNAs and their role in regulatory networks. The methodology can be applied to systematically investigate the differences in target genes and pathways of arbitrary miRNA sets. -target gene hsa-mir-205 Osteoporosis 26170952 The miR-205 antisense largely abolished the inhibitory effect of STAT3 activation on the levels of CHOP protein. -target gene hsa-mir-7 Prostate Neoplasms 26172296 MicroRNA-7 inhibits the stemness of prostate cancer stem-like cells and tumorigenesis by repressing KLF4/PI3K/Akt/p21 pathway. -target gene hsa-mir-133a "Carcinoma, Hepatocellular" 26173501 "MicroRNA-145 and MicroRNA-133a Inhibited Proliferation, Migration, and Invasion, While Promoted Apoptosis in Hepatocellular Carcinoma Cells Via Targeting FSCN1." -target gene hsa-mir-145 "Carcinoma, Hepatocellular" 26173501 "MicroRNA-145 and MicroRNA-133a Inhibited Proliferation, Migration, and Invasion, While Promoted Apoptosis in Hepatocellular Carcinoma Cells Via Targeting FSCN1." -target gene hsa-mir-18a Gastric Neoplasms 26173586 MicroRNA-18a modulates P53 expression by targeting IRF2 in gastric cancer patients. -target gene hsa-mir-206 Coronary Artery Disease 26175229 "Role of the microRNA, miR-206, and its target PIK3C2¦Á in endothelial progenitor cell function ¨C potential link with coronary artery disease." -target gene hsa-mir-17 Systemic Lupus Erythematosus 26175399 Targeting E2F1 and c-Myc expression by microRNA-17-5p represses interferon-stimulated gene MxA in peripheral blood mononuclear cells of pediatric systemic lupus erythematosus patients. -target gene hsa-mir-139 Ischemic Heart Disease 26175501 "Gene enrichment studies of hsa-miR-139-5p,hsa-miR-483-3p targets demonstrated an association with cardiovascular disease, cell death,and metabolism." -target gene hsa-mir-483 Ischemic Heart Disease 26175501 "Gene enrichment studies of hsa-miR-139-5p,hsa-miR-483-3p targets demonstrated an association with cardiovascular disease, cell death,and metabolism." -target gene hsa-mir-302c Glioma 26176806 MiR-302c-3p suppresses invasion and proliferation of glioma cells via down-regulating metadherin (MTDH) expression. -target gene hsa-mir-324 "Carcinoma, Hepatocellular" 26177288 MiR-324-5p Suppresses Hepatocellular Carcinoma Cell Invasion by Counteracting ECM Degradation through Post-Transcriptionally Downregulating ETS1 and SP1. -target gene hsa-mir-203a Lung Neoplasms 26177443 "ERGIC3, which is regulated by miR-203a, is a potential biomarker for non-small cell lung cancer." -target gene hsa-mir-129 Glioblastoma 26180082 Neurotensin signaling stimulates glioblastoma cell proliferation by upregulating c-Myc and inhibiting miR-29b-1 and miR-129-3p. -target gene hsa-mir-29b-1 Glioblastoma 26180082 Neurotensin signaling stimulates glioblastoma cell proliferation by upregulating c-Myc and inhibiting miR-29b-1 and miR-129-3p. -target gene hsa-mir-4487 Neuroblastoma 26183158 we identified that miR-4487 and miR-595 could target ULK1 and experimentally verified they could negatively or positively regulate ULK1-mediated autophagy -target gene hsa-mir-595 Neuroblastoma 26183158 Identification of ULK1 as a novel biomarker involved in miR-4487 and miR-595 regulation in neuroblastoma SH-SY5Y cell autophagy. -target gene hsa-mir-200a Lung Neoplasms 26184032 "MicroRNA-200a Targets EGFR and c-Met to Inhibit Migration, Invasion, and Gefitinib Resistance in Non-Small Cell Lung Cancer." -target gene hsa-mir-16 Infection [unspecific] 26184511 miR- 16 targeted the 3â€?untranslated region of IL-6 and suppressed its translation in mesangial cells induced by SIgA. -target gene hsa-mir-135b Atherosclerosis 26184978 MiR-135b-5p and MiR-499a-3p Promote Cell Proliferation and Migration in Atherosclerosis by Directly Targeting MEF2C. -target gene hsa-mir-499a Atherosclerosis 26184978 MiR-135b-5p and MiR-499a-3p Promote Cell Proliferation and Migration in Atherosclerosis by Directly Targeting MEF2C. -target gene hsa-mir-34a Human Immunodeficiency Virus Infection 26188041 "The miRNA miR-34a enhances HIV-1 replication by targeting PNUTS/PPP1R10, which negatively regulates HIV-1 transcriptional complex formation." -target gene hsa-mir-1238 Lung Neoplasms 26189214 miR-1238 inhibits cell proliferation by targeting LHX2 in non-small cell lung cancer. -target gene hsa-mir-122a "Carcinoma, Hepatocellular" 26189916 Targeted Regression of Hepatocellular Carcinoma by Cancer-Specific RNA Replacement through miR-122a Regulation. -target gene hsa-mir-302a Colorectal Carcinoma 26191138 Up-regulation of microRNA-302a inhibited the proliferation and invasion of colorectal cancer cells by regulation of the MAPK and PI3K/Akt signaling pathways. -target gene hsa-mir-139 Oral Neoplasms 26191149 MiRNA-139 regulates oral cancer Tca8113 cells apoptosis through Akt signaling pathway. -target gene hsa-mir-21 Cholangiocarcinoma 26191158 MicroRNA-21 regulates biological behavior by inducing EMT in human cholangiocarcinoma. -target gene hsa-mir-199a Endometriosis 26191163 MiR-199a inhibits the angiogenic potential of endometrial stromal cells under hypoxia by targeting HIF-1¦Á/VEGF pathway. -target gene hsa-mir-126 "Squamous Cell Carcinoma, Esophageal" 26191164 MicroRNA-126 is down-regulated in human esophageal squamous cell carcinoma and inhibits the proliferation and migration in EC109 cell via PI3K/AKT signaling pathway. -target gene hsa-mir-182 "Carcinoma, Cervical" 26191165 miR-182 induces cervical cancer cell apoptosis through inhibiting the expression of DNMT3a. -target gene hsa-mir-21 "Squamous Cell Carcinoma, Tongue" 26191167 Targeting miR-21 with AS-miR-21 suppresses aggressive growth of human tongue squamous cell carcinoma in vivo. -target gene hsa-mir-26b "Carcinoma, Hepatocellular" 26191168 "MiR-26b inhibits hepatocellular carcinoma cell proliferation, migration, and invasion by targeting EphA2." -target gene hsa-mir-365 Lymphoma 26191184 "MicroRNA-365 inhibits growth, invasion and metastasis of malignant melanoma by targeting NRP1 expression." -target gene hsa-mir-191 Endometriosis 26191186 MiR-191 inhibits TNF-¦Á induced apoptosis of ovarian endometriosis and endometrioid carcinoma cells by targeting DAPK1. -target gene hsa-mir-1297 "Carcinoma, Hepatocellular" 26191190 MicroRNA-1297 regulates hepatocellular carcinoma cell proliferation and apoptosis by targeting EZH2. -target gene hsa-mir-204 Breast Neoplasms 26191195 MicroRNA-204 targets JAK2 in breast cancer and induces cell apoptosis through the STAT3/BCl-2/survivin pathway. -target gene hsa-mir-185 Gastric Neoplasms 26191199 TRIM29 functions as an oncogene in gastric cancer and is regulated by miR-185. -target gene hsa-mir-10b "Carcinoma, Gastric" 26191201 Augmented miR-10b expression associated with depressed expression of its target gene KLF4 involved in gastric carcinoma. -target gene hsa-mir-107 "Carcinoma, Hepatocellular" 26191213 Our observations suggested that miR-107 could promote HCC cells proliferation via targeting Axin2 and might represent a potential therapeutic target for HCC. -target gene hsa-mir-144 Lung Neoplasms 26191328 "Expression of miR-144 is reduced in malignant SPN tissues and peripheral blood, being of clinical value in the diagnosis of malignant SPN.miR-144 promotes the apoptosis of lung cancer cells, and inhibits the proliferation, invasion and migration of lung cancer by regulating ZEB1 gene." -target gene hsa-mir-21 "Carcinoma, Colon" 26193421 The S100P/RAGE signaling pathway regulates expression of microRNA-21 in colon cancer cells. -target gene hsa-mir-325 "Carcinoma, Hepatocellular" 26194496 These findings implied that miR-325 regulates cell invasion and proliferation via targeting HMGB1 and may be a potential prognostic marker for HCC. -target gene hsa-mir-21 Neoplasms [unspecific] 26194786 "the miRNA-21 target is cyclically reused, and many MB-DNA fuel strands are attached to the sensor surface, leading to a significantly amplified current response for sensitive detection of miRNA-21 down to 1.4 fM. The developed sensor also shows high sequence discrimination capability and can be used to monitor miRNA-21 expression levels in cancer cells. Moreover, this sensor avoids the involvement of any enzymes for target recycling amplification and features with highly minimized background noise for miRNA detection, which makes this method hold great potential for convenient monitoring of different miRNA biomarkers for early diagnosis of various cancers." -target gene hsa-mir-34a Bladder Neoplasms 26198939 MicroRNA-34a regulates cell cycle by targeting CD44 in human bladder carcinoma cells. -target gene hsa-mir-720 Chronic Hepatitis B 26199080 therapies targeting miR-720 may help restore impaired immunity in chronic HBV infection (CHB) patients. -target gene hsa-mir-29a Diabetes Mellitus 26199111 "Using gain- and loss-of-function studies, five of these genes were confirmed as endogenous targets of miR-29a" -target gene hsa-mir-15b Japanese Encephalitis Virus Infection 26202983 MicroRNA-15b Modulates Japanese Encephalitis Virus-Mediated Inflammation via Targeting RNF125. -target gene hsa-mir-200c Neoplasms [unspecific] 26203557 miR-200c dampens cancer cell migration via regulation of protein kinase A subunits. -target gene hsa-mir-26b "Carcinoma, Ovarian" 26204489 MiR-26b/KPNA2 axis inhibits epithelial ovarian carcinoma proliferation and metastasis through downregulating OCT4. -target gene hsa-mir-335 Neoplasms [unspecific] 26204513 Our data suggest that differences in response to miR-335 by tumor cells may lie in part in the mechanism of regulation of MT1-MMP production. -target gene hsa-mir-539 Thyroid Neoplasms 26206083 MiR-539 inhibits thyroid cancer cell migration and invasion by directly targeting CARMA1. -target gene hsa-mir-21 Pulmonary Hypertension 26208095 these results demonstrate that PPAR¦Ã ligands regulate proliferative responses to hypoxia by preventing hypoxic increases in miR-21 and reductions in PTEN. These findings further clarify molecular mechanisms that support targeting PPAR¦Ã to attenuate pathogenic derangements in PH. -target gene hsa-mir-25 Glioblastoma 26209061 miR-25 promotes glioblastoma cell proliferation and invasion by directly targeting NEFL. -target gene hsa-mir-1246 "Carcinoma, Lung, Non-Small-Cell" 26209100 "These results suggested that the miR-1246 may promote cell metastasis by targeting CPEB4. Meanwhile, the level of CPEB4 could be used as a potential marker in NSCLC patients. Our findings unraveled novel functions of miR-1246 in lung cancer cells and shed light on NSCLC prognosis." -target gene hsa-mir-21 "Carcinoma, Hepatocellular" 26210448 MiR-21 promoted proliferation and migration in hepatocellular carcinoma through negative regulation of Navigator-3. -target gene hsa-mir-205 Prostate Neoplasms 26211479 Editorial Comment to MicroRNA-205 inhibits cancer cell migration and invasion via modulation of centromere protein F regulating pathways in prostate cancer. -target gene hsa-mir-29c Alzheimer Disease 26212654 miR-29c regulates NAV3 protein expression in a transgenic mouse model of Alzheimer's disease. -target gene hsa-mir-335 Gastrointestinal Stromal Tumor 26214687 "Our results suggest that miR-34a and miR-335 are candidate tumor suppressive miRNAs in GISTs, and that they are frequent targets of epigenetic silencing in GISTs." -target gene hsa-mir-34a Gastrointestinal Stromal Tumor 26214687 "Our results suggest that miR-34a and miR-335 are candidate tumor suppressive miRNAs in GISTs, and that they are frequent targets of epigenetic silencing in GISTs." -target gene hsa-mir-194 "Carcinoma, Hepatocellular" 26221053 NF-¦ÊB signaling relieves negative regulation by miR-194 in hepatocellular carcinoma by suppressing the transcription factor HNF-1¦Á. -target gene hsa-mir-143 Cardiovascular Diseases [unspecific] 26221598 We discuss the potential role of miR-143/-145 as valuable biomarkers for cardiovascular diseases and explore the potential strategy of targeting miR-143 and miR-145. -target gene hsa-mir-145 Cardiovascular Diseases [unspecific] 26221598 We discuss the potential role of miR-143/-145 as valuable biomarkers for cardiovascular diseases and explore the potential strategy of targeting miR-143 and miR-145. -target gene hsa-mir-223 Coronary Artery Disease 26221610 "our recent data demonstrated that the level of both intraplatelet and circulating miR-223 is an independent predictor for HTPR, thus providing a link between miR-223 and MACE. These lines of evidence indicate that miR-223 may serve as a potential regulatory target for HTPR, as well as a diagnostic tool for identification of HTPR in clinical settings." -target gene hsa-mir-149 Ovarian Neoplasms 26223974 Our findings suggest that miRNA-149 mediates the susceptibility of paclitaxel by regulating MyD88 expression in ovarian cancer cells. -target gene hsa-mir-375 "Carcinoma, Cervical" 26224081 miR-375 Modulates Radiosensitivity of HR-HPV-Positive Cervical Cancer Cells by Targeting UBE3A through the p53 Pathway. -target gene hsa-mir-204 Pulmonary Hypertension 26224795 BRD4 expression in PAH is microRNA-204 dependent -target gene hsa-mir-198 Neoplasms [unspecific] 26225959 we have identified that miR-198 inhibited HaCaT cell proliferation by directly targeting CCND2. -target gene hsa-mir-320a "Leukemia, Myeloid, Chronic" 26228085 MicroRNA-320a acts as a tumor suppressor by targeting BCR/ABL oncogene in chronic myeloid leukemia. -target gene hsa-mir-21 Bladder Neoplasms 26230405 microRNA-21 Regulates Cell Proliferation and Migration and Cross Talk with PTEN and p53 in Bladder Cancer. -target gene hsa-mir-503 Prostate Neoplasms 26231797 miR-503 suppresses tumor cell proliferation and metastasis by directly targeting RNF31 in prostate cancer. -target gene hsa-mir-214 "Squamous Cell Carcinoma, Esophageal" 26234674 Overexpression of miR-214-3p in esophageal squamous cancer cells enhances sensitivity to cisplatin by targeting survivin directly and indirectly through CUG-BP1. -target gene hsa-mir-135a Lung Neoplasms 26235874 MiR-135a inhibits migration and invasion and regulates EMT-related marker genes by targeting KLF8 in lung cancer cells. -target gene hsa-mir-219 "Carcinoma, Colon" 26238082 miR-219-5p plays a tumor suppressive role in colon cancer by targeting oncogene Sall4. -target gene hsa-mir-497 Ovarian Neoplasms 26238185 MiR-497 decreases cisplatin resistance in ovarian cancer cells by targeting mTOR/P70S6K1. -target gene hsa-mir-145 "Carcinoma, Lung, Non-Small-Cell" 26238532 MicroRNA-145 inhibits migration and invasion via inhibition of fascin 1 protein expression in non-small-cell lung cancer cells. -target gene hsa-mir-146a "Carcinoma, Lung, Non-Small-Cell" 26238771 MicroRNA-146a inhibits epithelial mesenchymal transition in non-small cell lung cancer by targeting insulin receptor substrate 2. -target gene hsa-mir-138 "Squamous Cell Carcinoma, Oral" 26239136 miR-138 suppresses the proliferation of oral squamous cell carcinoma cells by targeting Yes-associated protein 1. -target gene hsa-mir-126 "Carcinoma, Thyroid" 26239517 miR-126 inhibits papillary thyroid carcinoma growth by targeting LRP6. -target gene hsa-mir-205 Breast Neoplasms 26239614 MicroRNA-205 inhibits the proliferation and invasion of breast cancer by regulating AMOT expression. -target gene hsa-mir-29b-2 Glioblastoma 26240386 "our findings reveal a novel function of YB-1 in regulating non-coding RNA expression, which has important implications in tumorigenesis." -target gene hsa-mir-224 "Squamous Cell Carcinoma, Esophageal" 26245343 "The current study demonstrated that miR-224 acts as an oncogenic miRNA in esophageal squamous cell carcinoma (ESCC), possibly by targeting PHLPP1 and PHLPP2." -target gene hsa-mir-587 Colorectal Carcinoma 26247730 MicroRNA-587 antagonizes 5-FU-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer. -target gene hsa-mir-124 Colorectal Carcinoma 26248089 miR124 inhibits DNA synthesis and proliferation by reducing levels of pentose phosphate pathway enzymes in CRC cells. Expression of miR124 and its targets correlate with survival times and might be used in prognosis. -target gene hsa-mir-200c "Carcinoma, Renal Cell" 26248649 miR-200c Targets CDK2 and Suppresses Tumorigenesis in Renal Cell Carcinoma. -target gene hsa-mir-221 Multiple Myeloma 26249174 Targeting the miR-221-222/PUMA/BAK/BAX Pathway Abrogates Dexamethasone Resistance in Multiple Myeloma. -target gene hsa-mir-222 Multiple Myeloma 26249174 Targeting the miR-221-222/PUMA/BAK/BAX Pathway Abrogates Dexamethasone Resistance in Multiple Myeloma. -target gene hsa-mir-638 "Carcinoma, Gastric" 26250158 MicroRNA-638 inhibits cell proliferation by targeting phospholipase D1 in human gastric carcinoma. -target gene hsa-mir-34c "Carcinoma, Lung, Non-Small-Cell" 26250586 "miR-34c-3p directly targeted eIF4E and reduced miR-34c-3p expression in NSCLC, promoting cell cycle progression, proliferation, migration and invasion." -target gene hsa-mir-144 Glioblastoma 26250785 miR-144-3p exerts anti-tumor effects in glioblastoma by targeting c-Met. -target gene hsa-mir-221 "Carcinoma, Hepatocellular" 26251599 Targeted delivery of chemically modified anti-miR-221 to hepatocellular carcinoma with negatively charged liposomes. -target gene hsa-mir-24 Bladder Neoplasms 26252200 "MicroRNA-24 upregulation inhibits proliferation, metastasis and induces apoptosis in bladder cancer cells by targeting CARMA3." -target gene hsa-mir-122 "Carcinoma, Hepatocellular" 26252254 MicroRNA-122 affects cell aggressiveness and apoptosis by targeting PKM2 in human hepatocellular carcinoma. -target gene hsa-mir-21 Prostate Neoplasms 26252635 IL-6 Inhibits the Targeted Modulation of PDCD4 by miR-21 in Prostate Cancer. -target gene hsa-mir-132 "Carcinoma, Hepatocellular" 26252738 "MiR-132 inhibits cell proliferation, invasion and migration of hepatocellular carcinoma by targeting PIK3R3." -target gene hsa-mir-338 Breast Neoplasms 26252944 MicroRNA-338-3p functions as tumor suppressor in breast cancer by targeting SOX4. -target gene hsa-let-7a Allergic Asthma 26253882 "miRNAs are important post-transcriptional regulators of gene expression and have a role in allergic type 2 immune responses through their activity in multiple immune and non-immune cell subsets. Detailed mechanistic studies are critically needed to understand and leverage miRNAs to advance the field and inform clinical investigation. miRNAs act through multiple direct targets to regulate networks of genes, and their specificity and potency depends on the dynamics of individual miRNA-target interactions. Identifying which miRNAs and which targets are important for promoting or restraining allergy will help to identify vulnerable nodes in allergic inflammation, enhancing our mechanistic understanding of miRNA in the immune system and providing novel, possibly druggable, targets for these increasingly prevalent diseases." -target gene hsa-mir-106a Allergic Asthma 26253882 "miRNAs are important post-transcriptional regulators of gene expression and have a role in allergic type 2 immune responses through their activity in multiple immune and non-immune cell subsets. Detailed mechanistic studies are critically needed to understand and leverage miRNAs to advance the field and inform clinical investigation. miRNAs act through multiple direct targets to regulate networks of genes, and their specificity and potency depends on the dynamics of individual miRNA-target interactions. Identifying which miRNAs and which targets are important for promoting or restraining allergy will help to identify vulnerable nodes in allergic inflammation, enhancing our mechanistic understanding of miRNA in the immune system and providing novel, possibly druggable, targets for these increasingly prevalent diseases." -target gene hsa-mir-124 Allergic Asthma 26253882 "miRNAs are important post-transcriptional regulators of gene expression and have a role in allergic type 2 immune responses through their activity in multiple immune and non-immune cell subsets. Detailed mechanistic studies are critically needed to understand and leverage miRNAs to advance the field and inform clinical investigation. miRNAs act through multiple direct targets to regulate networks of genes, and their specificity and potency depends on the dynamics of individual miRNA-target interactions. Identifying which miRNAs and which targets are important for promoting or restraining allergy will help to identify vulnerable nodes in allergic inflammation, enhancing our mechanistic understanding of miRNA in the immune system and providing novel, possibly druggable, targets for these increasingly prevalent diseases." -target gene hsa-mir-126 Allergic Asthma 26253882 "miRNAs are important post-transcriptional regulators of gene expression and have a role in allergic type 2 immune responses through their activity in multiple immune and non-immune cell subsets. Detailed mechanistic studies are critically needed to understand and leverage miRNAs to advance the field and inform clinical investigation. miRNAs act through multiple direct targets to regulate networks of genes, and their specificity and potency depends on the dynamics of individual miRNA-target interactions. Identifying which miRNAs and which targets are important for promoting or restraining allergy will help to identify vulnerable nodes in allergic inflammation, enhancing our mechanistic understanding of miRNA in the immune system and providing novel, possibly druggable, targets for these increasingly prevalent diseases." -target gene hsa-mir-135 Allergic Asthma 26253882 "miRNAs are important post-transcriptional regulators of gene expression and have a role in allergic type 2 immune responses through their activity in multiple immune and non-immune cell subsets. Detailed mechanistic studies are critically needed to understand and leverage miRNAs to advance the field and inform clinical investigation. miRNAs act through multiple direct targets to regulate networks of genes, and their specificity and potency depends on the dynamics of individual miRNA-target interactions. Identifying which miRNAs and which targets are important for promoting or restraining allergy will help to identify vulnerable nodes in allergic inflammation, enhancing our mechanistic understanding of miRNA in the immune system and providing novel, possibly druggable, targets for these increasingly prevalent diseases." -target gene hsa-mir-142 Allergic Asthma 26253882 "miRNAs are important post-transcriptional regulators of gene expression and have a role in allergic type 2 immune responses through their activity in multiple immune and non-immune cell subsets. Detailed mechanistic studies are critically needed to understand and leverage miRNAs to advance the field and inform clinical investigation. miRNAs act through multiple direct targets to regulate networks of genes, and their specificity and potency depends on the dynamics of individual miRNA-target interactions. Identifying which miRNAs and which targets are important for promoting or restraining allergy will help to identify vulnerable nodes in allergic inflammation, enhancing our mechanistic understanding of miRNA in the immune system and providing novel, possibly druggable, targets for these increasingly prevalent diseases." -target gene hsa-mir-145 Allergic Asthma 26253882 "miRNAs are important post-transcriptional regulators of gene expression and have a role in allergic type 2 immune responses through their activity in multiple immune and non-immune cell subsets. Detailed mechanistic studies are critically needed to understand and leverage miRNAs to advance the field and inform clinical investigation. miRNAs act through multiple direct targets to regulate networks of genes, and their specificity and potency depends on the dynamics of individual miRNA-target interactions. Identifying which miRNAs and which targets are important for promoting or restraining allergy will help to identify vulnerable nodes in allergic inflammation, enhancing our mechanistic understanding of miRNA in the immune system and providing novel, possibly druggable, targets for these increasingly prevalent diseases." -target gene hsa-mir-146 Allergic Asthma 26253882 "miRNAs are important post-transcriptional regulators of gene expression and have a role in allergic type 2 immune responses through their activity in multiple immune and non-immune cell subsets. Detailed mechanistic studies are critically needed to understand and leverage miRNAs to advance the field and inform clinical investigation. miRNAs act through multiple direct targets to regulate networks of genes, and their specificity and potency depends on the dynamics of individual miRNA-target interactions. Identifying which miRNAs and which targets are important for promoting or restraining allergy will help to identify vulnerable nodes in allergic inflammation, enhancing our mechanistic understanding of miRNA in the immune system and providing novel, possibly druggable, targets for these increasingly prevalent diseases." -target gene hsa-mir-150 Allergic Asthma 26253882 "miRNAs are important post-transcriptional regulators of gene expression and have a role in allergic type 2 immune responses through their activity in multiple immune and non-immune cell subsets. Detailed mechanistic studies are critically needed to understand and leverage miRNAs to advance the field and inform clinical investigation. miRNAs act through multiple direct targets to regulate networks of genes, and their specificity and potency depends on the dynamics of individual miRNA-target interactions. Identifying which miRNAs and which targets are important for promoting or restraining allergy will help to identify vulnerable nodes in allergic inflammation, enhancing our mechanistic understanding of miRNA in the immune system and providing novel, possibly druggable, targets for these increasingly prevalent diseases." -target gene hsa-mir-155 Allergic Asthma 26253882 "miRNAs are important post-transcriptional regulators of gene expression and have a role in allergic type 2 immune responses through their activity in multiple immune and non-immune cell subsets. Detailed mechanistic studies are critically needed to understand and leverage miRNAs to advance the field and inform clinical investigation. miRNAs act through multiple direct targets to regulate networks of genes, and their specificity and potency depends on the dynamics of individual miRNA-target interactions. Identifying which miRNAs and which targets are important for promoting or restraining allergy will help to identify vulnerable nodes in allergic inflammation, enhancing our mechanistic understanding of miRNA in the immune system and providing novel, possibly druggable, targets for these increasingly prevalent diseases." -target gene hsa-mir-193 Allergic Asthma 26253882 "miRNAs are important post-transcriptional regulators of gene expression and have a role in allergic type 2 immune responses through their activity in multiple immune and non-immune cell subsets. Detailed mechanistic studies are critically needed to understand and leverage miRNAs to advance the field and inform clinical investigation. miRNAs act through multiple direct targets to regulate networks of genes, and their specificity and potency depends on the dynamics of individual miRNA-target interactions. Identifying which miRNAs and which targets are important for promoting or restraining allergy will help to identify vulnerable nodes in allergic inflammation, enhancing our mechanistic understanding of miRNA in the immune system and providing novel, possibly druggable, targets for these increasingly prevalent diseases." -target gene hsa-mir-21 Allergic Asthma 26253882 "miRNAs are important post-transcriptional regulators of gene expression and have a role in allergic type 2 immune responses through their activity in multiple immune and non-immune cell subsets. Detailed mechanistic studies are critically needed to understand and leverage miRNAs to advance the field and inform clinical investigation. miRNAs act through multiple direct targets to regulate networks of genes, and their specificity and potency depends on the dynamics of individual miRNA-target interactions. Identifying which miRNAs and which targets are important for promoting or restraining allergy will help to identify vulnerable nodes in allergic inflammation, enhancing our mechanistic understanding of miRNA in the immune system and providing novel, possibly druggable, targets for these increasingly prevalent diseases." -target gene hsa-mir-221 Allergic Asthma 26253882 "miRNAs are important post-transcriptional regulators of gene expression and have a role in allergic type 2 immune responses through their activity in multiple immune and non-immune cell subsets. Detailed mechanistic studies are critically needed to understand and leverage miRNAs to advance the field and inform clinical investigation. miRNAs act through multiple direct targets to regulate networks of genes, and their specificity and potency depends on the dynamics of individual miRNA-target interactions. Identifying which miRNAs and which targets are important for promoting or restraining allergy will help to identify vulnerable nodes in allergic inflammation, enhancing our mechanistic understanding of miRNA in the immune system and providing novel, possibly druggable, targets for these increasingly prevalent diseases." -target gene hsa-mir-223 Allergic Asthma 26253882 "miRNAs are important post-transcriptional regulators of gene expression and have a role in allergic type 2 immune responses through their activity in multiple immune and non-immune cell subsets. Detailed mechanistic studies are critically needed to understand and leverage miRNAs to advance the field and inform clinical investigation. miRNAs act through multiple direct targets to regulate networks of genes, and their specificity and potency depends on the dynamics of individual miRNA-target interactions. Identifying which miRNAs and which targets are important for promoting or restraining allergy will help to identify vulnerable nodes in allergic inflammation, enhancing our mechanistic understanding of miRNA in the immune system and providing novel, possibly druggable, targets for these increasingly prevalent diseases." -target gene hsa-mir-29 Allergic Asthma 26253882 "miRNAs are important post-transcriptional regulators of gene expression and have a role in allergic type 2 immune responses through their activity in multiple immune and non-immune cell subsets. Detailed mechanistic studies are critically needed to understand and leverage miRNAs to advance the field and inform clinical investigation. miRNAs act through multiple direct targets to regulate networks of genes, and their specificity and potency depends on the dynamics of individual miRNA-target interactions. Identifying which miRNAs and which targets are important for promoting or restraining allergy will help to identify vulnerable nodes in allergic inflammation, enhancing our mechanistic understanding of miRNA in the immune system and providing novel, possibly druggable, targets for these increasingly prevalent diseases." -target gene hsa-mir-365 Allergic Asthma 26253882 "miRNAs are important post-transcriptional regulators of gene expression and have a role in allergic type 2 immune responses through their activity in multiple immune and non-immune cell subsets. Detailed mechanistic studies are critically needed to understand and leverage miRNAs to advance the field and inform clinical investigation. miRNAs act through multiple direct targets to regulate networks of genes, and their specificity and potency depends on the dynamics of individual miRNA-target interactions. Identifying which miRNAs and which targets are important for promoting or restraining allergy will help to identify vulnerable nodes in allergic inflammation, enhancing our mechanistic understanding of miRNA in the immune system and providing novel, possibly druggable, targets for these increasingly prevalent diseases." -target gene hsa-mir-375 Allergic Asthma 26253882 "miRNAs are important post-transcriptional regulators of gene expression and have a role in allergic type 2 immune responses through their activity in multiple immune and non-immune cell subsets. Detailed mechanistic studies are critically needed to understand and leverage miRNAs to advance the field and inform clinical investigation. miRNAs act through multiple direct targets to regulate networks of genes, and their specificity and potency depends on the dynamics of individual miRNA-target interactions. Identifying which miRNAs and which targets are important for promoting or restraining allergy will help to identify vulnerable nodes in allergic inflammation, enhancing our mechanistic understanding of miRNA in the immune system and providing novel, possibly druggable, targets for these increasingly prevalent diseases." -target gene hsa-mir-452 Allergic Asthma 26253882 "miRNAs are important post-transcriptional regulators of gene expression and have a role in allergic type 2 immune responses through their activity in multiple immune and non-immune cell subsets. Detailed mechanistic studies are critically needed to understand and leverage miRNAs to advance the field and inform clinical investigation. miRNAs act through multiple direct targets to regulate networks of genes, and their specificity and potency depends on the dynamics of individual miRNA-target interactions. Identifying which miRNAs and which targets are important for promoting or restraining allergy will help to identify vulnerable nodes in allergic inflammation, enhancing our mechanistic understanding of miRNA in the immune system and providing novel, possibly druggable, targets for these increasingly prevalent diseases." -target gene hsa-mir-615 Allergic Asthma 26253882 "miRNAs are important post-transcriptional regulators of gene expression and have a role in allergic type 2 immune responses through their activity in multiple immune and non-immune cell subsets. Detailed mechanistic studies are critically needed to understand and leverage miRNAs to advance the field and inform clinical investigation. miRNAs act through multiple direct targets to regulate networks of genes, and their specificity and potency depends on the dynamics of individual miRNA-target interactions. Identifying which miRNAs and which targets are important for promoting or restraining allergy will help to identify vulnerable nodes in allergic inflammation, enhancing our mechanistic understanding of miRNA in the immune system and providing novel, possibly druggable, targets for these increasingly prevalent diseases." -target gene hsa-mir-130a Liver Fibrosis 26255201 These findings suggest that miR-130a and miR-130b are involved in downregulation of PPARγ in liver fibrosis. -target gene hsa-mir-27b Liver Fibrosis 26255201 "In carbon tetrachloride injection (CCl4) and common bile duct ligation (CBDL) liver fibrosis models, miRNAs miR-130a, miR-130b, miR-301a, miR-27b and miR-340 levels were found to be increased and PPARγ expression decreased." -target gene hsa-mir-378a Breast Neoplasms 26255816 miR-378a-3p modulates tamoxifen sensitivity in breast cancer MCF-7 cells through targeting GOLT1A. -target gene hsa-mir-145 Intrahepatic Cholangiocarcinoma 26255969 MiR-145 functions as a tumor suppressor targeting NUAK1 in human intrahepatic cholangiocarcinoma. -target gene hsa-mir-512 "Squamous Cell Carcinoma, Head and Neck" 26258591 miR-512-5p suppresses tumor growth by targeting hTERT in telomerase positive head and neck squamous cell carcinoma in vitro and in vivo. -target gene hsa-mir-512 Alzheimer Disease 26258756 Reduced miR-512 and the Elevated Expression of Its Targets cFLIP and MCL1 Localize to Neurons With Hyperphosphorylated Tau Protein in Alzheimer Disease. -target gene hsa-mir-99b Colorectal Carcinoma 26259252 miRNA-99b-5p suppresses liver metastasis of colorectal cancer by down-regulating mTOR. -target gene hsa-mir-124 Osteosarcoma 26259653 MicroRNA-124 suppresses the migration and invasion of osteosarcoma cells via targeting ROR2-mediated non-canonical Wnt signaling. -target gene hsa-mir-744 Inflammation 26259828 "our data indicate that by targeting PTP1B, miR-744 plays a feed-forward role in regulating type I IFN signaling pathway. These findings give us new insights into the functions of renal miRNAs in regulating important signaling pathways." -target gene hsa-mir-338 "Carcinoma, Nasopharyngeal" 26260688 MicroRNA-338 inhibits migration and proliferation by targeting hypoxia-induced factor 1¦Á in nasopharyngeal carcinoma. -target gene hsa-mir-155 Lymphoma 26261072 Oncogenic microRNA-155 and its target PU.1: an integrative gene expression study in six of the most prevalent lymphomas. -target gene hsa-mir-7 "Carcinoma, Gastric" 26261179 MicroRNA-7/NF-¦ÊB signaling regulatory feedback circuit regulates gastric carcinogenesis. -target gene hsa-mir-218 Gastric Neoplasms 26261515 These findings suggest that miR-218 inhibits MDR of gastric cancer cells by down-regulating SMO expression. -target gene hsa-mir-15a Osteosarcoma 26261520 "MiRNA-15a inhibits proliferation, migration and invasion by targeting TNFAIP1 in human osteosarcoma cells." -target gene hsa-mir-126 Breast Neoplasms 26261534 "Thus, our study revealed that miR-126 may act as a tumor suppressor via inhibition of cell invasion by downregulating ADAM9 in breast cancer development." -target gene hsa-mir-630 Colorectal Carcinoma 26263387 CREB-miR-630-BCL2L2 and TP53RK comprise a novel signaling cascade regulating radiosensitivity in CRC cell lines by inducing cell apoptosis and death. -target gene hsa-mir-17 Myocardial Infarction 26265044 "The delivery of exogenous miR-17 suppressed Apaf-1 expression and consequently attenuated formation of the apoptosome complex containing caspase-9, as demonstrated by co-immunoprecipitation and immunocytochemistry." -target gene hsa-mir-106a Cardiovascular Diseases [unspecific] 26266261 Our current special issue presents a series of original researches and reviews on recent advances in miRNAs regulating the pathophysiology aspects of CVD that will hopefully set the stage for future research initiatives aimed at expanding our understanding of these important mediators of cardiovascular function. -target gene hsa-mir-106b Cardiovascular Diseases [unspecific] 26266261 Our current special issue presents a series of original researches and reviews on recent advances in miRNAs regulating the pathophysiology aspects of CVD that will hopefully set the stage for future research initiatives aimed at expanding our understanding of these important mediators of cardiovascular function. -target gene hsa-mir-125 Cardiovascular Diseases [unspecific] 26266261 Our current special issue presents a series of original researches and reviews on recent advances in miRNAs regulating the pathophysiology aspects of CVD that will hopefully set the stage for future research initiatives aimed at expanding our understanding of these important mediators of cardiovascular function. -target gene hsa-mir-126 Cardiovascular Diseases [unspecific] 26266261 Our current special issue presents a series of original researches and reviews on recent advances in miRNAs regulating the pathophysiology aspects of CVD that will hopefully set the stage for future research initiatives aimed at expanding our understanding of these important mediators of cardiovascular function. -target gene hsa-mir-143 Cardiovascular Diseases [unspecific] 26266261 Our current special issue presents a series of original researches and reviews on recent advances in miRNAs regulating the pathophysiology aspects of CVD that will hopefully set the stage for future research initiatives aimed at expanding our understanding of these important mediators of cardiovascular function. -target gene hsa-mir-145 Cardiovascular Diseases [unspecific] 26266261 Our current special issue presents a series of original researches and reviews on recent advances in miRNAs regulating the pathophysiology aspects of CVD that will hopefully set the stage for future research initiatives aimed at expanding our understanding of these important mediators of cardiovascular function. -target gene hsa-mir-17 Cardiovascular Diseases [unspecific] 26266261 Our current special issue presents a series of original researches and reviews on recent advances in miRNAs regulating the pathophysiology aspects of CVD that will hopefully set the stage for future research initiatives aimed at expanding our understanding of these important mediators of cardiovascular function. -target gene hsa-mir-18 Cardiovascular Diseases [unspecific] 26266261 Our current special issue presents a series of original researches and reviews on recent advances in miRNAs regulating the pathophysiology aspects of CVD that will hopefully set the stage for future research initiatives aimed at expanding our understanding of these important mediators of cardiovascular function. -target gene hsa-mir-19a Cardiovascular Diseases [unspecific] 26266261 Our current special issue presents a series of original researches and reviews on recent advances in miRNAs regulating the pathophysiology aspects of CVD that will hopefully set the stage for future research initiatives aimed at expanding our understanding of these important mediators of cardiovascular function. -target gene hsa-mir-19b-1 Cardiovascular Diseases [unspecific] 26266261 Our current special issue presents a series of original researches and reviews on recent advances in miRNAs regulating the pathophysiology aspects of CVD that will hopefully set the stage for future research initiatives aimed at expanding our understanding of these important mediators of cardiovascular function. -target gene hsa-mir-20a Cardiovascular Diseases [unspecific] 26266261 Our current special issue presents a series of original researches and reviews on recent advances in miRNAs regulating the pathophysiology aspects of CVD that will hopefully set the stage for future research initiatives aimed at expanding our understanding of these important mediators of cardiovascular function. -target gene hsa-mir-221 Cardiovascular Diseases [unspecific] 26266261 Our current special issue presents a series of original researches and reviews on recent advances in miRNAs regulating the pathophysiology aspects of CVD that will hopefully set the stage for future research initiatives aimed at expanding our understanding of these important mediators of cardiovascular function. -target gene hsa-mir-222 Cardiovascular Diseases [unspecific] 26266261 Our current special issue presents a series of original researches and reviews on recent advances in miRNAs regulating the pathophysiology aspects of CVD that will hopefully set the stage for future research initiatives aimed at expanding our understanding of these important mediators of cardiovascular function. -target gene hsa-mir-223 Cardiovascular Diseases [unspecific] 26266261 Our current special issue presents a series of original researches and reviews on recent advances in miRNAs regulating the pathophysiology aspects of CVD that will hopefully set the stage for future research initiatives aimed at expanding our understanding of these important mediators of cardiovascular function. -target gene hsa-mir-2861 Cardiovascular Diseases [unspecific] 26266261 Our current special issue presents a series of original researches and reviews on recent advances in miRNAs regulating the pathophysiology aspects of CVD that will hopefully set the stage for future research initiatives aimed at expanding our understanding of these important mediators of cardiovascular function. -target gene hsa-mir-3960 Cardiovascular Diseases [unspecific] 26266261 Our current special issue presents a series of original researches and reviews on recent advances in miRNAs regulating the pathophysiology aspects of CVD that will hopefully set the stage for future research initiatives aimed at expanding our understanding of these important mediators of cardiovascular function. -target gene hsa-mir-92-1 Cardiovascular Diseases [unspecific] 26266261 Our current special issue presents a series of original researches and reviews on recent advances in miRNAs regulating the pathophysiology aspects of CVD that will hopefully set the stage for future research initiatives aimed at expanding our understanding of these important mediators of cardiovascular function. -target gene hsa-mir-138 "Squamous Cell Carcinoma, Cerevial" 26267680 "miR-138 and miR-720 are the down-regulated target miRNAs in HPV16-positive squamous carcinoma of the cervix in the Uygur of southern Xinjiang. The common target gene for miR-138 and miR-720 is EZH2, which might be related to cervical squamous carcinoma invasion and metastasis." -target gene hsa-mir-720 "Squamous Cell Carcinoma, Cerevial" 26267680 "miR-138 and miR-720 are the down-regulated target miRNAs in HPV16-positive squamous carcinoma of the cervix in the Uygur of southern Xinjiang. The common target gene for miR-138 and miR-720 is EZH2, which might be related to cervical squamous carcinoma invasion and metastasis." -target gene hsa-mir-503 Microvascular Disease 26268439 "Collectively, our data demonstrate that miR-503 regulates pericyte-endothelial crosstalk in microvascular diabetic complications." -target gene hsa-mir-126 "Leukemia, Promyelocytic, Acute" 26274316 "These results demonstrate that ATO inhibits the growth of HUVECs and induces apoptosis by downregulating VEGFA. One mechanism by which this occurs is Ets-2 upregulation, which results in an increase in miR-126 levels and downregulation of VEGFA expression." -target gene hsa-mir-202 Osteosarcoma 26276504 This study provides new insights into miRNA-202 in osteosarcoma as a potential molecular target for chemotherapy. -target gene hsa-mir-761 "Carcinoma, Lung, Non-Small-Cell" 26278569 miR-761 promotes progression and metastasis of NSCLC by targeting ING4 and TIMP2. -target gene hsa-mir-205 "Carcinoma, Laryngeal" 26281062 miRNA-205 might promote the proliferation of Hep-2 cells by regulating the expression of PTEN. -target gene hsa-mir-185 Congenital Microtia 26282502 "The expression of has-miR-203, has-miR-200c and has-miR-451 were significantly different in microtia. Target gene of SOCS3, TFs of STAT1 and STAT2, and lncRNA of MALAT1 may play important roles in the development of the external ear." -target gene hsa-mir-200c Congenital Microtia 26282502 "The expression of has-miR-203, has-miR-200c and has-miR-451 were significantly different in microtia. Target gene of SOCS3, TFs of STAT1 and STAT2, and lncRNA of MALAT1 may play important roles in the development of the external ear." -target gene hsa-mir-203 Congenital Microtia 26282502 "The expression of has-miR-203, has-miR-200c and has-miR-451 were significantly different in microtia. Target gene of SOCS3, TFs of STAT1 and STAT2, and lncRNA of MALAT1 may play important roles in the development of the external ear." -target gene hsa-mir-451 Congenital Microtia 26282502 "The expression of has-miR-203, has-miR-200c and has-miR-451 were significantly different in microtia. Target gene of SOCS3, TFs of STAT1 and STAT2, and lncRNA of MALAT1 may play important roles in the development of the external ear." -target gene hsa-mir-664 Lymphoma 26287415 "Taken together, our results suggest that miR-664 may play an important role in suppressing proliferation of CMM cells and present a novel mechanism of miR-mediated direct suppression of PLP2 expression in cancer cells." -target gene hsa-mir-215 Colorectal Carcinoma 26287603 Identification of miR-215 mediated targets/pathways via translational immunoprecipitation expression analysis (TrIP-chip). -target gene hsa-mir-34a "Carcinoma, Rectal" 26287733 "Although miR-34a and miR-34c can regulate Axl expression in vitro,our data indicates that the miR-34 family members are not the primary regulators of Axl expression in RCC." -target gene hsa-mir-411 Rhabdomyosarcoma 26291313 "These results establish an autoregulatory loop between TGF-¦Â1/miR-411-5p/SPRY4 and MAPK in RMS, which governs the switch between proliferation and differentiation." -target gene hsa-mir-223 Tuberculosis 26296289 It is concluded that miR-223 can regulate macrophage function by inhibition of cytokine production and NF-¦ÊB activation. -target gene hsa-let-7b Ischemia-Reperfusion Injury 26296645 we report that let-7b targets caspase-3 to regulate apoptosis and autophagy in MSCs exposed to ROS. -target gene hsa-mir-139 Breast Neoplasms 26299922 MiR-139-5p not only attenuated the development of breast cancer cells but also mediated drug-resistance by regulating the expression of the downstream target gene Notch1. -target gene hsa-mir-137 Osteosarcoma 26302771 "We revealed novel functional role of miR-137 in osteosarcoma regulation, likely through FXYD6 binding." -target gene hsa-mir-155 Colorectal Carcinoma 26303353 "Thus, it is hypothesized that miR-155 may be a promising target for antagonizing COX-2 expression in colorectal and other cancers." -target gene hsa-mir-195 "Colitis, Ulcerative" 26303523 miR-195 plays a role in steroid resistance of ulcerative colitis by targeting Smad7. -target gene hsa-mir-203 "Carcinoma, Nasopharyngeal" 26304234 MiRNA-203 Reduces Nasopharyngeal Carcinoma Radioresistance by Targeting IL8/AKT Signaling. -target gene hsa-mir-17 "Lymphoma, Large B-Cell, Diffuse" 26305986 "In the present review, we focus on the role of the miR-17-92 cluster in lymphoproliferative disorders, including diagnostic/prognostic implications, and on the potential applications of anti-miRNAs based therapies targeting miRNAs belonging to the cluster." -target gene hsa-mir-18 "Lymphoma, Large B-Cell, Diffuse" 26305986 "In the present review, we focus on the role of the miR-17-92 cluster in lymphoproliferative disorders, including diagnostic/prognostic implications, and on the potential applications of anti-miRNAs based therapies targeting miRNAs belonging to the cluster." -target gene hsa-mir-19a "Lymphoma, Large B-Cell, Diffuse" 26305986 "In the present review, we focus on the role of the miR-17-92 cluster in lymphoproliferative disorders, including diagnostic/prognostic implications, and on the potential applications of anti-miRNAs based therapies targeting miRNAs belonging to the cluster." -target gene hsa-mir-19b-1 "Lymphoma, Large B-Cell, Diffuse" 26305986 "In the present review, we focus on the role of the miR-17-92 cluster in lymphoproliferative disorders, including diagnostic/prognostic implications, and on the potential applications of anti-miRNAs based therapies targeting miRNAs belonging to the cluster." -target gene hsa-mir-20a "Lymphoma, Large B-Cell, Diffuse" 26305986 "In the present review, we focus on the role of the miR-17-92 cluster in lymphoproliferative disorders, including diagnostic/prognostic implications, and on the potential applications of anti-miRNAs based therapies targeting miRNAs belonging to the cluster." -target gene hsa-mir-92-1 "Lymphoma, Large B-Cell, Diffuse" 26305986 "In the present review, we focus on the role of the miR-17-92 cluster in lymphoproliferative disorders, including diagnostic/prognostic implications, and on the potential applications of anti-miRNAs based therapies targeting miRNAs belonging to the cluster." -target gene hsa-mir-214 Huntington Disease 26307536 "In summary, we have shown that increased expression of miR-214 observed in HD cell model could target MFN2, altered mitochondrial morphology and deregulated cell cycle. Inhibition of miR-214 could be a possible target of intervention in HD pathogenesis." -target gene hsa-mir-712 Atherosclerosis 26308181 Multifunctional Nanoparticles Facilitate Molecular Targeting and miRNA Delivery to Inhibit Atherosclerosis in ApoE(-/-) Mice. -target gene hsa-mir-15a Pituitary Neoplasms 26309203 GAA-induced decrease in cell proliferation is associated with decreased expression of Bcl-2 and increased miR-15a. -target gene hsa-mir-18a Leukemia 26314433 The miR-18a can regulated the sensitivity of leukemia HL-60 cells to VP-16 and VCR by targeting ATM. -target gene hsa-mir-26a "Lymphoma, T-Cell" 26314438 that abnormal expression of miR-26a may participate in genesis and development of ENKTCL through regulating the expression of its target gene CDK6. -target gene hsa-mir-23a "Carcinoma, Nasopharyngeal" 26314966 MiR-23a sensitizes nasopharyngeal carcinoma to irradiation by targeting IL-8/Stat3 pathway. -target gene hsa-mir-99b "Squamous Cell Carcinoma, Oral" 26315788 miRNA-99b-3p functions as a potential tumor suppressor by targeting glycogen synthase kinase-3¦Â in oral squamous cell carcinoma Tca-8113 cells. -target gene hsa-mir-340 "Carcinoma, Esophageal" 26316084 MiR-340 functions as a tumor suppressor by modulating the expression of PSAT1 and may contribute to the progression and invasiveness of ESCC. -target gene hsa-mir-130b Lupus Nephritis 26316103 MiR-130b-3p negatively regulated ERBB2IP expression by directly targeting the 3'-UTR of ERBB2IP The circulating miR-130b-3p might serve as a biomarker and play an important role in renal damage in early stage LN patients. -target gene hsa-mir-10a "Carcinoma, Lung, Non-Small-Cell" 26317552 We found that PTEN was a direct target of miR-10a in NSCLC. Also miR-10a activated the PTEN/AKT/ERK pathway. We suggest that miR-10a contributes to NSCLC by targeting PTEN. -target gene hsa-mir-494 Chondrosarcoma 26317788 MicroRNA-494 inhibits cell proliferation and invasion of chondrosarcoma cells in vivo and in vitro by directly targeting SOX9. -target gene hsa-mir-940 Gastric Neoplasms 26317898 MicroRNA-940 promotes tumor cell invasion and metastasis by downregulating ZNF24 in gastric cancer. -target gene hsa-mir-134 Breast Neoplasms 26318721 MicroRNA-134 modulates resistance to doxorubicin in breast cancer cells by downregulating the expression of ABCC1 which is known to encode the multidrug resistance-associated protein 1. -target gene hsa-mir-34a "Squamous Cell Carcinoma, Head and Neck" 26323460 MicroRNA-34a regulates epithelial-mesenchymal transition and cancer stem cell phenotype of head and neck squamous cell carcinoma in vitro. -target gene hsa-mir-542 "Carcinoma, Esophageal" 26323919 "Taken together, our results indicated that miR-542-3p is a tumor suppressor of esophageal cancer acting at steps that regulate cell growth." -target gene hsa-mir-155 Tuberculosis 26324048 "From these results, it was concluded that mycobacteria can improve the level of miR-155, while BCG can induce apoptosis in THP-1 cells. The results suggested FOXO3 is a downstream target gene of miR-155, which combines 3'-UTRs to inhibit the expression of FOXO3." -target gene hsa-mir-34a "Carcinoma, Colon" 26324236 These findings demonstrate that miR-34a may act as a negative regulator in colon cancer by targeting PDGFRA. -target gene hsa-mir-221 Prostate Neoplasms 26325107 Loss of the tumour-suppressive miR-221/222 cluster enhanced migration and invasion in PCa cells. Our data describing targets regulated by the tumour-suppressive miR-221/222 cluster provide insights into the mechanisms of PCa and CRPC progression. -target gene hsa-mir-222 Prostate Neoplasms 26325107 Loss of the tumour-suppressive miR-221/222 cluster enhanced migration and invasion in PCa cells. Our data describing targets regulated by the tumour-suppressive miR-221/222 cluster provide insights into the mechanisms of PCa and CRPC progression. -target gene hsa-mir-206 Neoplasms [unspecific] 26325180 "Taken together, our results demonstrated that miR-206 suppressed c-Met and Bcl2 expression in NSCLS and could function as a potent tumor suppressor in c-Met/Bcl2-over expressing tumors. Inhibition of miR-206 function could contribute to aberrant cell proliferation, migration, invasion and apoptosis,leading to NSCLS development." -target gene hsa-mir-1908 Osteosarcoma 26328886 "Collectively, the results showed that, miR-1908 promotes proliferation and invasion of osteosarcoma cells by repressing PTEN expression." -target gene hsa-mir-372 "Carcinoma, Renal Cell" 26332146 Our data indicated that miR-372 seemed to function as a tumour suppressor in renal cell carcinoma progression by inhibiting the IGF2BP1 expression. -target gene hsa-mir-29a "Scleroderma, Systemic" 26335042 miRNA-29a in systemic sclerosis: A valid target. -target gene hsa-mir-212 Pancreatic Neoplasms 26337469 Pancreatic cancer-derived exosomes transfer miRNAs to dendritic cells and inhibit RFXAP expression via miR-212-3p. -target gene hsa-mir-1207 "Carcinoma, Lung, Non-Small-Cell" 26338522 "The three miR-1207-5p, miR-1228* and miR-939 are the most connected miRNA that regulated a large number of genes." -target gene hsa-mir-1228 "Carcinoma, Lung, Non-Small-Cell" 26338522 "The three miR-1207-5p, miR-1228* and miR-939 are the most connected miRNA that regulated a large number of genes." -target gene hsa-mir-939 "Carcinoma, Lung, Non-Small-Cell" 26338522 "The three miR-1207-5p, miR-1228* and miR-939 are the most connected miRNA that regulated a large number of genes." -target gene hsa-mir-182 Lung Neoplasms 26338969 These results suggest that modulation of miR-182 and miR-185 and their target genes may contribute to lung carcinogenesis attributable to PM2.5 exposure. -target gene hsa-mir-185 Lung Neoplasms 26338969 These results suggest that modulation of miR-182 and miR-185 and their target genes may contribute to lung carcinogenesis attributable to PM2.5 exposure. -target gene hsa-mir-124 Osteosarcoma 26339404 Our findings may help to understand the molecular mechanisms of OS and identify targets of effective targeted therapies for OS. -target gene hsa-mir-19b Osteosarcoma 26339404 Our findings may help to understand the molecular mechanisms of OS and identify targets of effective targeted therapies for OS. -target gene hsa-mir-20a Osteosarcoma 26339404 Our findings may help to understand the molecular mechanisms of OS and identify targets of effective targeted therapies for OS. -target gene hsa-mir-155 Colorectal Carcinoma 26340059 We further showed that miR-155 acted to repress the Warburg effect through the mechanism of inactivating the IL-6/STAT3 pathway. -target gene hsa-mir-200a "Squamous Cell Carcinoma, Esophageal" 26341629 These results reaffirm the potential role of MSA as a chemopreventive agent via the regulation of KLF4/miR-200a/Keap1/Nrf2 axis in ESCC cells. -target gene hsa-mir-21 "Carcinoma, Esophageal" 26345812 "Together,these results suggest that miR- 21 might be involved in the development and metastasis of esophageal cancer, through interaction with its PDCD4 and K-ras target genes." -target gene hsa-mir-101 Lung Neoplasms 26349988 miR-101 represses lung cancer by inhibiting interaction of fibroblasts and cancer cells by down-regulating CXCL12. -target gene hsa-mir-16 Osteoarthritis 26350536 Our results indicate that miR-16-5p is an important regulator of SMAD3 expression in human chondrocytes and may contribute to the development of OA. -target gene hsa-mir-128 Colorectal Carcinoma 26352220 "Taken together, these data suggested that miR-128 serves as a tumor suppressor and blocks CRC growth and metastasis by targeting IRS1." -target gene hsa-mir-675 Breast Neoplasms 26353930 H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b. -target gene hsa-mir-183 Endometriosis 26357653 "These findings, together with the fact that ITGB1 is a critical factor for cell adhesion and invasiveness, suggest that miR-183 may be involved in the development of endometriosis by regulating ITGB1 in endometrial stromal cells." -target gene hsa-mir-10b Breast Neoplasms 26359455 Combining miR-10b-Targeted Nanotherapy with Low-Dose Doxorubicin Elicits Durable Regressions of Metastatic Breast Cancer. -target gene hsa-mir-326 Gastric Neoplasms 26359764 "Our study demonstrated that miR-326 overexpression was a poor prognostic marker for gastric cancer patients, and miR-326 served as a tumor suppressor in gastric cancer via directly regulating FSCN1." -target gene hsa-mir-506 Gastric Neoplasms 26362716 "In conclusion, miR-506 was identified as an ETS1 targeting suppressor of metastatic invasion and angiogenesis in gastric cancer." -target gene hsa-mir-21 Breast Neoplasms 26363493 An immobilization-free electrochemical impedance biosensor based on duplex-specific nuclease assisted target recycling for amplified detection of microRNA. -target gene hsa-mir-19a Lung Neoplasms 26367773 Uncovering Direct Targets of MiR-19a Involved in Lung Cancer Progression. -target gene hsa-mir-141 Ischemic Heart Disease 26371161 MicroRNA-141 regulates the expression level of ICAM-1 on endothelium to decrease myocardial ischemia-reperfusion injury. -target gene hsa-mir-203 Osteosarcoma 26382657 "Take together, our results demonstrated that miR-203 act as a tumor suppressor miRNA through regulating RAB22A expression and suggested its involvement in osteosarcoma progression and carcinogenesis." -target gene hsa-mir-21 Coronary Artery Disease 26383248 "Because the smad7 expression pattern was similar to that of TGF-¦Â,our study suggests that miR-21 can negatively regulate the frequency of circulating Treg cells through a TGF-¦Â1/smad-independent signaling pathway in PBMCs." -target gene hsa-mir-34a "Carcinoma, Hepatocellular" 26385595 MiR-34a is Involved in the Decrease of ATP Contents Induced by Resistin Through Target on ATP5S in HepG2 Cells. -target gene hsa-mir-519c Colorectal Carcinoma 26386386 Exploiting a novel miR-519c-HuR-ABCG2 regulatory pathway to overcome chemoresistance in colorectal cancer. -target gene hsa-mir-185 "Carcinoma, Nasopharyngeal" 26390174 "Combined low miR-185-3p and miR-324-3p might be important markers for prediction of low response to RT/CRT and poor overall survival and recurrence-free survival.MiR-185-3p and miR-324-3p can modulate NPC cell growth and apoptosis, at least partly through targeting SMAD7." -target gene hsa-mir-324 "Carcinoma, Nasopharyngeal" 26390174 "Combined low miR-185-3p and miR-324-3p might be important markers for prediction of low response to RT/CRT and poor overall survival and recurrence-free survival.MiR-185-3p and miR-324-3p can modulate NPC cell growth and apoptosis, at least partly through targeting SMAD7." -target gene hsa-mir-10b Breast Neoplasms 26392359 Our work provides evidence for the involvement of specific miRNAs in triple-negative breast cancer development through regulating BRCA1 expression. -target gene hsa-mir-146a Breast Neoplasms 26392359 Our work provides evidence for the involvement of specific miRNAs in triple-negative breast cancer development through regulating BRCA1 expression. -target gene hsa-mir-153 Breast Neoplasms 26392359 Our work provides evidence for the involvement of specific miRNAs in triple-negative breast cancer development through regulating BRCA1 expression. -target gene hsa-mir-26a Breast Neoplasms 26392359 Our work provides evidence for the involvement of specific miRNAs in triple-negative breast cancer development through regulating BRCA1 expression. -target gene hsa-mir-32 Neoplasms [unspecific] 26394836 SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes -target gene hsa-mir-590 Neoplasms [unspecific] 26394836 SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes -target gene hsa-mir-133b Ovarian Neoplasms 26396496 "MicroRNA-133b may reduce ovarian cancer drug resistance by silencing the expression of the drug-resistance-related proteins, GST-¦Ð and MDR1. In future, the combination of miR-133b with chemotherapy agents may prevent the development of drug resistance in ovarian cancers." -target gene hsa-mir-205 "Carcinoma, Adrenocortical" 26397843 "In conclusion, miR-205 suppresses the growth of ACC SW-13 cells via targeting the anti-apoptotic gene Bcl-2." -target gene hsa-mir-18a Colorectal Carcinoma 26398009 "These findings demonstrate that miR-18a exhibits a protective role in CRC via inhibiting proliferation, invasion and migration of CRC cells by directly targeting the TBPL1 gene." -target gene hsa-mir-125a Gastric Neoplasms 26398444 "Collectively, our results indicated that miR-125a regulated the paracrine of VEGF-A in gastric cancer and thereby controlled the angiogenesis of the tumor." -target gene hsa-mir-222 Alzheimer Disease 26398571 "In conclusion, these results suggest that the abnormal expression of miR-222 may contribute to dysregulation of the cell-cycle in AD, at least in part by affecting the expression of p27Kip1." -target gene hsa-mir-211 "Carcinoma, Hepatocellular" 26398845 miR-211 promotes invasion of carcinoma cells by directly targeting ESR1. -target gene hsa-mir-200c Pancreatic Neoplasms 26400206 "More importantly, garcinol treatment led to the upregulation of several tumor suppressor microRNAs, and miR-200c increased by garcinol treatment was found to target and downregulate Notch1." -target gene hsa-mir-200c Breast Neoplasms 26400441 PDCD10 is a target gene of miR-200c and also a possible mechanism by which miR-200c plays a role in regulating the stemness of BCSCs and MaSCs. -target gene hsa-mir-34c Alzheimer Disease 26402112 MicroRNA-34c Downregulation Ameliorates Amyloid-¦Â-Induced Synaptic Failure and Memory Deficits by Targeting VAMP2. -target gene hsa-mir-140 Colorectal Carcinoma 26402430 Our results suggested a tumor suppressive role of miR-140-5p in CRC tumorigenesis and progression by targeting VEGFA. -target gene hsa-mir-100 Gastric Neoplasms 26404754 This study demonstrated that miR-100 could be induced by C/EBP¦Á and may act as a tumor suppressor gene by inhibiting ZBTB7A. -target gene hsa-mir-584 "Carcinoma, Thyroid" 26405762 "These results indicate that miR-584 could inhibit the expression of ROCK1, and ROCK1 knockdown would further affect the migration ability of K1 cells." -target gene hsa-mir-217 Lung Neoplasms 26415832 "The results indicate that miR-217 regulation of EZH2/H3K27me3 via MALAT1 is involved in CSE-induced EMT and malignant transformation of HBE cells. The posttranscriptional silencing of MALAT1 by miR-217 provides a link, through EZH2,between ncRNAs and the EMT and establishes a mechanism for CSE-induced lung carcinogenesis." -target gene hsa-mir-25 Lung Neoplasms 26416661 Elevated microRNA-25 inhibits cell apoptosis in lung cancer by targeting RGS3. -target gene hsa-mir-21 "Carcinoma, Colon" 26418978 "MiR-21 can mediate the drug resistance to 5-FU by inhibiting its target PDCD4,which can regulate the expression of ABCC5 and CD44 genes." -target gene hsa-mir-96 "Carcinoma, Renal Cell" 26419932 These results suggest that miR-96 suppresses RCC invasion by modulating Ezrin expression. -target gene hsa-mir-21 Colorectal Carcinoma 26419959 Our data support a possible role of tumor epigenetic deregulation by noncoding RNA in suppressing the antitumor T-cell-mediated adaptive immune response and suggest MIR21 as a potential target for immunotherapy and prevention in colorectal cancer. -target gene hsa-mir-222 "Carcinoma, Hepatocellular" 26420065 all the four miRNAs synergistically target PBX3 -target gene hsa-mir-21 Polycystic Ovarian Syndrome 26427146 "In comparison with normal subjects, serum miR-21 is obviously increased in PCOS patients. Through targeting LATS1, miR-21 could prompt PCOS progression and could act as a novel non-invasive biomarker for diagnosis of PCOS." -target gene hsa-mir-135b "Carcinoma, Hepatocellular" 26429530 miR-135b promotes the invasion and metastasis possibly by targeting the Hippo pathway genes. -target gene hsa-mir-133 Roberts Syndrome 26434741 miR-133-dependent cx43 overexpression rescues esco2-dependent growth defects -target gene hsa-mir-130a Chronic Inflammation 26436920 "Therefore,miR-142-5p and miR-130a-3p regulate macrophage profibrogenic gene expression in chronic inflammation." -target gene hsa-mir-142 Chronic Inflammation 26436920 "Therefore,miR-142-5p and miR-130a-3p regulate macrophage profibrogenic gene expression in chronic inflammation." -target gene hsa-mir-92 Breast Neoplasms 26437339 miR-92 is gradually lost in breast epithelial cells during cancer progression correlating with a shift in ER¦Â1 immunoreactivity from nuclei to the cytoplasm. Our data support a functional role in fibroblasts where modification of miR-92 expression can influence the invasive capacity of breast cancer epithelial cells. However in silico analysis suggests that ER¦Â1 may not be the most important miR-92 target in breast cancer. -target gene hsa-mir-137 Astrocytoma 26440052 miR-137 acts as a tumor suppressor in astrocytoma by targeting RASGRF1. -target gene hsa-mir-145 Lung Neoplasms 26440147 "In aggregate, our results attribute to miR-145-5p and its direct targets pivotal roles in malignancy progression and in metastasis." -target gene hsa-mir-133a Heart Failure 26440278 miR-133a acts as a repressor of SRF and CTGF expression -target gene hsa-mir-139 Glioblastoma 26449464 We concluded that ectopic expression of miR-139-5p in GBM cell lines significantly suppressed cell proliferation and inducing apoptosis. Bioinformatics coupled with luciferase and western blot assays also revealed that miR-139-5p suppresses glioma cell proliferation by targeting ELTD1 and regulating cell cycle. -target gene hsa-mir-93 Glioma 26449498 "In conclusion, our results suggest an increasing role of miR-93 in regulating the level of expression of several genes involved in the angiogenesis of gliomas." -target gene hsa-mir-19b "Carcinoma, Hepatocellular" 26453548 "The overexpression of miR-19b was significantly correlated with better disease-free and overall survival in patients with HCC presenting with vascular invasion or multifocal disease after curative surgery. MiR-19b may influence the expression of NDRG1, EPCAM, HMGB2, HIF1A, and MAPK14." -target gene hsa-mir-29c Uterine Leiomyoma 26453978 "MiR-29c expression is suppressed in leiomyoma, resulting in an increase in expression of its targets COL3A1 and DNMT3A. The suppression of miR-29c in LSMC is primarily mediated by SP1, NF-¦ÊB signaling, and epigenetic modification. Collectively, these results indicate a significant role for miR-29c in leiomyoma pathogenesis." -target gene hsa-mir-302b "Carcinoma, Hepatocellular" 26457704 This study showed that miR-302b could enhance the sensitivity to 5-FU in HCC cell lines and verified its two putative targeted genes responsible for its 5-FU sensitivity. -target gene hsa-mir-26a Gastric Neoplasms 26458859 "Our results suggest that miR-26a can improve the sensitivity of GC cells to cisplatin-based chemotherapies through targeting NRAS and E2F2, and provide the first evidence of the potential utility of miR-26a as a sensitizer in chemotherapy for GC." -target gene hsa-let-7a Breast Neoplasms 26460550 "Our research revealed the mechanisms through which miR-208a functioned in breast cancer and BrCSCs, and identified the miR-208a-SOX2/¦Â-catenin-LIN28-let-7a-DICER1 regulatory feedback loop in regulations of stem cells renewal." -target gene hsa-mir-208a Breast Neoplasms 26460550 "Our research revealed the mechanisms through which miR-208a functioned in breast cancer and BrCSCs, and identified the miR-208a-SOX2/¦Â-catenin-LIN28-let-7a-DICER1 regulatory feedback loop in regulations of stem cells renewal." -target gene hsa-mir-101 Gastric Neoplasms 26460960 "We conclude that miR-27b,miR-101 and miR-128 inhibit angiogenesis by down-regulating VEGF-C expression in gastric cancers." -target gene hsa-mir-128 Gastric Neoplasms 26460960 "We conclude that miR-27b,miR-101 and miR-128 inhibit angiogenesis by down-regulating VEGF-C expression in gastric cancers." -target gene hsa-mir-27b Gastric Neoplasms 26460960 "We conclude that miR-27b,miR-101 and miR-128 inhibit angiogenesis by down-regulating VEGF-C expression in gastric cancers." -target gene hsa-mir-221 Cardiovascular Diseases [unspecific] 26461283 "Among differentially-expressed miRNAs are those involved in the regulation of inflammation or cell adhesion, such as miR-221 and miR-181." -target gene hsa-mir-7 "Carcinoma, Lung, Non-Small-Cell" 26464649 This study further extends the biological role of miR-7 in NSCLC A549 and H460 cells and identifies BCL-2 as a novel target possibly involved in miR-7-mediated growth suppression and apoptosis induction of NSCLC cells. -target gene hsa-mir-29 Neoplasms [unspecific] 26470025 MiR-29 restrained K562 cell growth and proliferation. MiR-29 induced K562 cell apoptosis through down-regulating FoxM1. -target gene hsa-mir-182 Ovarian Neoplasms 26472020 "In normal FTSE cells, miR-182 overexpression triggers cellular senescence by p53-mediated upregulation of p21." -target gene hsa-mir-320a "Carcinoma, Cervical" 26472185 CREB1-driven expression of miR-320a promotes mitophagy by down-regulating VDAC1 expression during serum starvation in cervical cancer cells. -target gene hsa-mir-378g Neoplasms [unspecific] 26473472 "MiR-378g enhanced radiosensitivity partially by targeting SHP-1 in NPC cells. Cell invasion was also partially inhibited by miR-378g, but the effect was not mediated by SHP-1." -target gene hsa-mir-30a Neoplasms [unspecific] 26473838 "In summary, we uncovered the protective function of miR30a targeting NFATc3 in the regulation of podocyte injury response to EMT." -target gene hsa-mir-138 Prostate Neoplasms 26474967 "miR-138 specifically targeted K2 and inhibited its expression, thereby regulating a miR-138/K2/β1-integrin signaling axis in mCRPC that is critical for the modulation of sensitivity to chemotherapeutics." -target gene hsa-mir-1 Cardiomegaly 26476318 "Further findings indicated that miR-1, which was depressed by Nkx2.5, might play a fundamental role in mediating cardiac hypertrophy and arrhythmia via its target genes Mef2a and Irx5 after HBCD treatment." -target gene hsa-mir-1271 Ovarian Neoplasms 26477861 Low levels of miR-1271 in ovarian cancer tissues promoted cancer cell growth. MiR-1271 may be a new predictor of prognosis in ovarian cancer.MiR-1271 exerted its role by targeting CCNG1. -target gene hsa-mir-125b Sepsis 26482503 miR-125b modulates PCT expression by manipulating the amount and transcriptional activity of Stat3. -target gene hsa-mir-19a Atherosclerosis 26483345 Endothelial Hypoxia-Inducible Factor-1¦Á Promotes Atherosclerosis and Monocyte Recruitment by Upregulating MicroRNA-19a. -target gene hsa-mir-342 Lung Neoplasms 26483346 miR-342-3p regulates MYC transcriptional activity via direct repression of E2F1 in human lung cancer. -target gene hsa-mir-30 Atherosclerosis 26488467 Upregulation of miR-30 by HFD may impair the protective effects of endothelial cell autophagy against development of atherosclerosis through suppressing protein translation of ATG6. -target gene hsa-mir-146a Osteoarthritis 26492575 "Simply, hypoxia induced HIF-1α, and HIF-1α increased miR-146a, but miR-146a suppressed Bcl-2, an autophagy inhibitor." -target gene hsa-mir-124 Colorectal Carcinoma 26497367 "In conclusion, our data showed that miR-124 and miR-506 inhibit progression and increase sensitivity to chemotherapy by targeting DNMT3B and DNMT1 in CRC. These findings may provide novel avenues for the development of targeted therapies." -target gene hsa-mir-506 Colorectal Carcinoma 26497367 "In conclusion, our data showed that miR-124 and miR-506 inhibit progression and increase sensitivity to chemotherapy by targeting DNMT3B and DNMT1 in CRC. These findings may provide novel avenues for the development of targeted therapies." -target gene hsa-mir-331 "Carcinoma, Hepatocellular" 26497554 "Upregulated in Hepatitis B virus-associated hepatocellular carcinoma cells,miR-331-3p promotes proliferation of hepatocellular carcinoma cells by targeting ING5." -target gene hsa-mir-155 "Lymphoma, B-Cell" 26497687 "miR-155 targeting of DET1, NIAM, TRIM32, HOMEZ, PSIP1 and JARID2." -target gene hsa-mir-139 Lung Neoplasms 26497851 "Taken together, our results demonstrated that miR-139-5p plays a pivotal role in lung cancer through inhibiting cell proliferation, metastasis, and promoting apoptosis by targeting oncogenic c-Met." -target gene hsa-mir-542 Osteosarcoma 26498360 "Taken together, our results indicated that miR-542-5p plays a critical role in the proliferation of osteosarcoma and targets HUWE1." -target gene hsa-mir-652 Pancreatic Neoplasms 26498682 MiR-652 inhibits acidic microenvironment-induced epithelial-mesenchymal transition of pancreatic cancer cells by targeting ZEB1. -target gene hsa-mir-34a Prostate Neoplasms 26499184 "Collectively, miR-34a enhances chemosensitivity by directly downregulating ATG4B-induced autophagy through AMPK/mTOR pathway in PCa." -target gene hsa-mir-616 "Carcinoma, Hepatocellular" 26499912 "Based on these results, we conclude that miR-616 is a promising prognostic biomarker of HCC and targeting miR-616 may be a potential option to prevent the progression of HCC." -target gene hsa-mir-519 "Leukemia, Myeloid, Acute" 26499919 The results of the present study indicate that miR-519 may contribute to HL60 cell apoptosis by regulating the expression of HuR. -target gene hsa-mir-221 Choriocarcinoma 26501139 "In conclusion, our results suggested that miR-221 promotes EMT through targeting PTEN and forms a positive feedback loop with ¦Â-catenin/c-Jun signaling pathway in EHCC." -target gene hsa-mir-19a "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 26502748 "Our preliminary outcomes suggest the utility of miR-19a in the challenging differential diagnosis of laryngeal VSCC. Although miR-19a has been found to regulate SOCS-1 expression, this evidence was not confirmed by this investigation." -target gene hsa-mir-449a Glioma 26502848 "The expression of microRNA-449a is low in patients with glioma,which may inhibit the proliferation of glioma and promote its cell apoptosis via affecting the expression of PKC¦Á." -target gene hsa-mir-221 Breast Neoplasms 26503209 "a pro-apoptotic Bcl-2 family protein, was up-regulated by the knockdown of miR-221." -target gene hsa-mir-154 "Carcinoma, Hepatocellular" 26503460 "In conclusion, these results indicate that miR-154 functions as a tumor suppressor in HCC by suppressing ZEB2,suggesting that miR-154 may serve as a potential target for HCC." -target gene hsa-mir-125b Gastric Neoplasms 26504803 miR-125b Suppresses Proliferation and Invasion by Targeting MCL1 in Gastric Cancer. -target gene hsa-mir-223 Tuberculosis 26505221 "Our data provide new clues for the essential role of miR-223 in the regulation of anti-Mtb-directed immune responses, which relies on the regulation of FOXO3 expression." -target gene hsa-mir-223 Prostate Neoplasms 26509963 Tumor-suppressive microRNA-223 inhibits cancer cell migration and invasion by targeting ITGA3/ITGB1 signaling in prostate cancer. -target gene hsa-mir-7 "Carcinoma, Breast, Triple Negative" 26513016 "Our results not only revealed IL-6 as a key regulator of lapatinib-induced metastasis, but also explored the requirement of miR7/Raf-1/MAPK/AP-1 axis in lapatinib-induced IL-6 expression." -target gene hsa-mir-30a Enterovirus Infection 26515789 "We provided further evidence that by modulating cellular miR-30a level through either overexpression or inhibition, one can inhibit or promote EV71 replication, respectively, through regulating autophagic activity." -target gene hsa-mir-451 Breast Neoplasms 26516138 "Increased miR-451 expression may negatively regulate Bcl-2 mRNA and protein expression, followed by affecting the protein expression of caspase 3,and accelerate the apoptosis in breast cancer, indicating that miR-451 might influence the drug resistances of the Paclitaxel-resistant breast cancer cell line." -target gene hsa-mir-182 Hepatitis C Virus Infection 26518141 "miR-182 was never investigated before, neither in HCV infection nor in NK cells, and we found it to have dysregulated expression in both liver tissues and NK cells of HCV-infected patients compared to control. In addition to that, miR-182 was found to have a contradicting effect in both effector cell and its HCV-infected target cell regarding HCV replication." -target gene hsa-mir-346 "Carcinoma, Cervical" 26518874 miR-346 Up-regulates Argonaute 2 (AGO2) Protein Expression to Augment the Activity of Other MicroRNAs (miRNAs) and Contributes to Cervical Cancer Cell Malignancy. -target gene hsa-mir-27b Atherosclerosis 26520906 The results presented here provide evidence that short-term modulation of miR-27b expression in wild-type mice regulates hepatic LDLR and ABCA1 expression but does not influence plasma and hepatic lipid levels. -target gene hsa-mir-126 Systemic Lupus Erythematosus 26531267 miRNA-126 expression is reduced in SLE patients. miRNA-126 may be involved in the initiation and development of SLE by inhibiting the production of IFN. -target gene hsa-mir-125b Breast Neoplasms 26531722 miR-125a-5p/miR-125b suppress the expression of TSTA3 -target gene hsa-mir-21 Breast Neoplasms 26531758 "In conclusion, our results demonstrated that plasma miR-21 levels may serve as a diagnostic marker in breast cancers, whereas miR-21 promotes breast cancer cell proliferation and invasion by suppressing smad7, which enhances EGF and TGF-¦Â pathways." -target gene hsa-mir-19 Pancreatic Neoplasms 26531836 A positive feedback loop of p53/miR-19/TP53INP1 modulates pancreatic cancer cell proliferation and apoptosis. -target gene hsa-let-7b Prostate Neoplasms 26540468 "Finally, we hypothesized that miR-218, miR-145, miR-197, miR-149, miR-122, and let-7b may contribute to the development of CRPC through the influence of Ras, Rho proteins,and the SCF complex. Further investigation is needed to verify the functions of the identified novel pathways in CRPC development." -target gene hsa-mir-122 Prostate Neoplasms 26540468 "Finally, we hypothesized that miR-218, miR-145, miR-197, miR-149, miR-122, and let-7b may contribute to the development of CRPC through the influence of Ras, Rho proteins,and the SCF complex. Further investigation is needed to verify the functions of the identified novel pathways in CRPC development." -target gene hsa-mir-124 Prostate Neoplasms 26540468 "Finally, we hypothesized that miR-218, miR-145, miR-197, miR-149, miR-122, and let-7b may contribute to the development of CRPC through the influence of Ras, Rho proteins,and the SCF complex. Further investigation is needed to verify the functions of the identified novel pathways in CRPC development." -target gene hsa-mir-125b Prostate Neoplasms 26540468 "Finally, we hypothesized that miR-218, miR-145, miR-197, miR-149, miR-122, and let-7b may contribute to the development of CRPC through the influence of Ras, Rho proteins,and the SCF complex. Further investigation is needed to verify the functions of the identified novel pathways in CRPC development." -target gene hsa-mir-145 Prostate Neoplasms 26540468 "Finally, we hypothesized that miR-218, miR-145, miR-197, miR-149, miR-122, and let-7b may contribute to the development of CRPC through the influence of Ras, Rho proteins,and the SCF complex. Further investigation is needed to verify the functions of the identified novel pathways in CRPC development." -target gene hsa-mir-149 Prostate Neoplasms 26540468 "Finally, we hypothesized that miR-218, miR-145, miR-197, miR-149, miR-122, and let-7b may contribute to the development of CRPC through the influence of Ras, Rho proteins,and the SCF complex. Further investigation is needed to verify the functions of the identified novel pathways in CRPC development." -target gene hsa-mir-197 Prostate Neoplasms 26540468 "Finally, we hypothesized that miR-218, miR-145, miR-197, miR-149, miR-122, and let-7b may contribute to the development of CRPC through the influence of Ras, Rho proteins,and the SCF complex. Further investigation is needed to verify the functions of the identified novel pathways in CRPC development." -target gene hsa-mir-218 Prostate Neoplasms 26540468 "Finally, we hypothesized that miR-218, miR-145, miR-197, miR-149, miR-122, and let-7b may contribute to the development of CRPC through the influence of Ras, Rho proteins,and the SCF complex. Further investigation is needed to verify the functions of the identified novel pathways in CRPC development." -target gene hsa-mir-340 "Squamous Cell Carcinoma, Oral" 26541225 The findings suggest that miR-340 might act as a molecular switch that contributes to the regulation of glycolysis in OSCC by regulating Glut1 expression. -target gene hsa-mir-381 Kidney Neoplasms 26541837 "MiRNA-381 can inhibit cell invasion in renal cancer by block the function of CBP, ¦Â-catenin and LEF-1." -target gene hsa-mir-33a "Carcinoma, Cervical" 26541838 "Twist1 is critical for the invasiveness of cervical cancer cells;miR-33a, as a tumor suppressor gene, functions as an upstream regulator of Twist1 and is involved in the invasiveness of cervical cancer cell." -target gene hsa-mir-506 Liver Neoplasms 26549227 "Thus, we conclude that miR-506 depresses the angiogenesis of liver cancer through targeting 3'UTR of SPHK1 mRNA. Our finding provides new insights into the mechanism of tumor angiogenesis." -target gene hsa-mir-21 Breast Neoplasms 26549725 "Our data suggest that miR-21 expression is increased in breast cancer and plays an important role as a tumor gene by targeting STAT3, which may act as a double-response controller in breast cancer." -target gene hsa-mir-150 Inflammation 26549736 "miR-150 can effectively prevent CD28/B7 co-stimulatory signaling transduction, decrease production of inflammatory cytokines, such as IL-2 and TNF, and elicit the induction of immune tolerance." -target gene hsa-mir-133a Vascular Hypertrophy 26553694 Of 37 direct targets of miR-133a defined in unstressed hearts -target gene hsa-mir-30a Preeclampsia 26555189 MiR-30a attenuates immunosuppressive functions of IL-1¦Â-elicited mesenchymal stem cells via targeting TAB3 -target gene hsa-mir-590 Glioblastoma 26556542 "miR-590-3p suppresses cancer cell migration, invasion and epithelial-mesenchymal transition in glioblastoma multiforme by targeting ZEB1 and ZEB2." -target gene hsa-mir-21 Glioblastoma 26558781 "Further, analysis of the miR-21-Sox2 relationship in mouse neural stem cells and in the mouse brain at different developmental stages indicates that miR-21 and Sox2 are predominantly expressed in mutually exclusive patterns, suggesting a role in normal neural development." -target gene hsa-mir-29b Gastric Neoplasms 26564501 miR-29b can enhance the sensitivity of S gastric cancer cell by directly targeting PI3K/Akt pathway. -target gene hsa-mir-181b Breast Neoplasms 26572075 "In summary, the results of the present study suggest that miR-181b functions as an oncogene during breast cancer development, and the miR-181b/Bim pathway may be a novel target used to overcome the chemoresistance in breast cancer." -target gene hsa-mir-214 Cardiomegaly 26572862 These results provide the first clear link between miRNAs and direct regulation of XBP1 in heart failure and reveal that miR-214 and miR-30* synergistically regulates cardiac VEGF expression and angiogenesis by targeting XBP1 in the progression from adaptive hypertrophy to heart failure. -target gene hsa-mir-214 Heart Failure 26572862 These results provide the first clear link between miRNAs and direct regulation of XBP1 in heart failure and reveal that miR-214 and miR-30* synergistically regulates cardiac VEGF expression and angiogenesis by targeting XBP1 in the progression from adaptive hypertrophy to heart failure. -target gene hsa-mir-30 Cardiomegaly 26572862 These results provide the first clear link between miRNAs and direct regulation of XBP1 in heart failure and reveal that miR-214 and miR-30* synergistically regulates cardiac VEGF expression and angiogenesis by targeting XBP1 in the progression from adaptive hypertrophy to heart failure. -target gene hsa-mir-30 Heart Failure 26572862 These results provide the first clear link between miRNAs and direct regulation of XBP1 in heart failure and reveal that miR-214 and miR-30* synergistically regulates cardiac VEGF expression and angiogenesis by targeting XBP1 in the progression from adaptive hypertrophy to heart failure. -target gene hsa-mir-130a Ovarian Neoplasms 26573160 "NRP1 is targeted by miR-130a and miR-130b, and is associated with multidrug resistance in epithelial ovarian cancer based on integrated gene network analysis." -target gene hsa-mir-130b Ovarian Neoplasms 26573160 "NRP1 is targeted by miR-130a and miR-130b, and is associated with multidrug resistance in epithelial ovarian cancer based on integrated gene network analysis." -target gene hsa-mir-101 Gastric Neoplasms 26573417 "In conclusion, the results of the present study suggested that miR-101 inhibited the proliferation and promoted DDP-induced apoptosis of DDP-resistant gastric cancer cells, at least in part via targeting VEGF-C." -target gene hsa-mir-382 Ovarian Neoplasms 26575700 "these findings revealed that miR-382 inhibits migration and invision by targeting ROR1 through regulating EMT in ovarian cancer, and might serve as a tumor suppressor in ovarian cancer." -target gene hsa-mir-181a "Leukemia, Lymphoblastic, Acute" 26580398 ectopic expression of miR-181a also resulted in decreased CD10 hyperexpression in ETV6/RUNX1+ primary patient samples. -target gene hsa-mir-197 Enterovirus Infection 26581983 Host MicroRNA miR-197 Plays a Negative Regulatory Role in the Enterovirus 71 Infectious Cycle by Targeting the RAN Protein. -target gene hsa-mir-3151 Malignant Neoplasms [unspecific] 26582795 "In conclusion, we identify miR-3151 as a previously unidentified player in MM and PTC pathogenesis, which is driven by BRAF-dependent and BRAF-independent mechanisms. Characterization of TP53 as a downstream effector of miR-3151 provides evidence for a causal link between BRAF mutations and TP53 inactivation." -target gene hsa-mir-661 Glioma 26585488 "These results indicate that miR-661 can inhibit glioma cell proliferation,migration and invasion by targeting hTERT." -target gene hsa-mir-196b "Carcinoma, Lung, Non-Small-Cell" 26586336 homeobox A9 (HOXA9) as a target gene of miR-196b -target gene hsa-mir-205 Neoplasms [unspecific] 26586569 miR-205 is upregulated upon NF-κB activation and suppresses COMMD1 expression in stemness-enriched cancer cells. -target gene hsa-mir-124 Alzheimer Disease 26592243 "our study indicates that miR-124 plays neuroprotective roles in AD Drosophila by targeting Delta in Notch signaling pathway, which helps further our understanding of miRNAs in the molecular pathology of AD." -target gene hsa-mir-762 Breast Neoplasms 26597380 These results demonstrate that miR-762 tumour effect was achieved by targeting IRF7 in human breast cancer specimens. -target gene hsa-mir-211 Melanoma 26599548 Overexpression of mature miR-211 in Bcl-2 overexpressing cells rescued Bcl-2 ability to increase cell migration. -target gene hsa-mir-203 Bladder Neoplasms 26599571 "In conclusion, decreased miR-203 predicts progression and poor prognosis for BC patients treated with cisplatin-based chemotherapy while miR-203 overexpression can enhance cisplatin sensitization by promoting apoptosis via directly targeting Bcl-w and Survivin." -target gene hsa-mir-302c Influenza 26602079 Mir-302c mediates influenza A virus-induced IFN¦Â expression by targeting NF-¦ÊB inducing kinase. -target gene hsa-mir-181c Neoplasms [unspecific] 26607087 Transfection with miR-181 mimics can suppress glycolysis in CAFs by inhibiting HK2 expression. -target gene hsa-mir-4458 "Carcinoma, Colon" 26607110 "In conclusion, our findings suggested that miR-4458 inhibited the progression of colon cancer cells by inhibition of glycolysis and lactate production via directly targeting HK2 mRNA." -target gene hsa-mir-99 Neoplasms [unspecific] 26608597 "We have developed an efficient SVM-based model for miRNA target prediction using recent CLIP-seq data, demonstrating superior performance, evaluated using ROC curves, specifically about 20 % better than the state-of-the-art, for different species (human or mouse), or different target types (canonical or non-canonical). To the best of our knowledge we provide the first distributed framework for microRNA target prediction based on Apache Hadoop and Spark." -target gene hsa-mir-200c Pancreatic Neoplasms 26609108 "Paradoxically, targeting eIF4E, the best-characterized effector of MNKs, increases ZEB1 mRNA expression through repression of ZEB1-targeting miRNAs, miR-200c and miR-141." -target gene hsa-mir-200b Retinal Degeneration 26617758 MiR-200b can regulate RECs growth and proliferation by changing VEGF and TGF¦Â1 expression to delay DR. -target gene hsa-mir-133b Ovarian Neoplasms 26617770 "Altogether, our results indicated that miR-133b overexpression was shown to inhibit proliferation and invasion of OC cells through suppression of the MAPK and PI3K/Akt signaling pathways by targeting EGFR." -target gene hsa-mir-203 Chronic Obstructive Pulmonary Disease 26617776 miR-203 represses NF-¦ÊB signaling via targeting TAK1 and PI3KCA and miR-203 overexpression may contribute to the COPD initiation. -target gene hsa-mir-631 Prostate Neoplasms 26620225 "In all, our study demonstrates that miR-631 decreases PCa cell migration and invasion by dampening ZAP70 expression." -target gene hsa-mir-181b "Carcinoma, Lung, Non-Small-Cell" 26620926 "Consequently, miR-181b functions as a tumor suppressor and has an important role in proliferation, chemosensitivity to DDP and metastasis of NSCLC by targeting TGF¦ÂR1/Smad signaling pathway." -target gene hsa-mir-181b Acute Lung Injury 26622531 he overexpression of miR-181b resulted in the induction of an increment in interleukin (IL)-6 levels. -target gene hsa-mir-143 "Squamous Cell Carcinoma, Oral" 26625772 "Low levels of miR-380-5p and miR-504 that directly target the 3'UTR of TP53 suggest that p53 may not be repressed by these two miRNAs in OSCC. On the other hand, low levels of miR-34a or miR-143 may relieve MDM4 and SIRT1 or MDM2 respectively, which will sequester p53 indicating an indirect mode of p53 suppression in oral tumors." -target gene hsa-mir-34a "Squamous Cell Carcinoma, Oral" 26625772 "Low levels of miR-380-5p and miR-504 that directly target the 3'UTR of TP53 suggest that p53 may not be repressed by these two miRNAs in OSCC. On the other hand, low levels of miR-34a or miR-143 may relieve MDM4 and SIRT1 or MDM2 respectively, which will sequester p53 indicating an indirect mode of p53 suppression in oral tumors." -target gene hsa-mir-151a Asthenozoospermia 26626315 These results indicate that miR-151a-5p may participate in the regulation of cellular respiration and ATP production through targeting Cytb. -target gene hsa-mir-186 Ovarian Neoplasms 26626440 Our results are the first to demonstrate that miR-186 may sensitize ovarian cancer cell to paclitaxel and cisplatin by targeting ABCB1 and modulating the expression of GST-¦Ð. -target gene hsa-mir-96 "Squamous Cell Carcinoma, Tongue" 26629033 MiR-96 is confirmed to be a direct target of MTSS1 gene and could regulate MTSS1 mediated Tca8113 cells proliferation and metastasis. -target gene hsa-mir-16 Cervical Neoplasms 26629104 CCNE1 gene is targeted by miR-16-1 in CC cells. -target gene hsa-mir-212 Post-Traumatic Stress Disorder 26632874 "DICER1 is an enzyme that generates mature microRNAs (miRNAs), which regulate gene expression post-transcriptionally in brain and other tissues and is involved in synaptic maturation and plasticity. Here, through genome-wide differential gene expression survey of post-traumatic stress disorder (PTSD) with comorbid depression (PTSD&Dep), we find that blood DICER1 expression is significantly reduced in cases versus controls, and replicate this in two independent cohorts. " -target gene hsa-mir-3130 Post-Traumatic Stress Disorder 26632874 "DICER1 is an enzyme that generates mature microRNAs (miRNAs), which regulate gene expression post-transcriptionally in brain and other tissues and is involved in synaptic maturation and plasticity. Here, through genome-wide differential gene expression survey of post-traumatic stress disorder (PTSD) with comorbid depression (PTSD&Dep), we find that blood DICER1 expression is significantly reduced in cases versus controls, and replicate this in two independent cohorts. " -target gene hsa-mir-153 Neuroblastoma 26633009 A Proteomics Approach to Investigate miR-153-3p and miR-205-5p Targets in Neuroblastoma Cells. -target gene hsa-mir-205 Neuroblastoma 26633009 A Proteomics Approach to Investigate miR-153-3p and miR-205-5p Targets in Neuroblastoma Cells. -target gene hsa-mir-150 Prostate Neoplasms 26636522 Increased miR-150 expression might participate in the development and progression of human prostate CSC by suppressing p27. This supported our previous study which found miR-150 was positively correlated with prostate tumor recurrence or metastasis. -target gene hsa-mir-375 Lung Neoplasms 26642205 "Thus, our study demonstrates the differential expression profiles of miR-375 in 3 subtypes of lung carcinomas and finds thatmiR-375 directly targets ITPKB and promoted cell growth in SCLC cell line." -target gene hsa-mir-512 "Carcinoma, Lung, Non-Small-Cell" 26648284 "In conclusion, our present study revealed miR-512-5p was able to target p21 to induce apoptosis and inhibit glycolysis in A549 and H1299 cell lines." -target gene hsa-mir-1908 Renal Fibrosis 26648305 miR-1908 could inhibit renal fibrosis through targeting TGF-¦Â1. -target gene hsa-mir-200b Glioma 26648487 MicroRNA-200b inhibits the growth and metastasis of glioma cells via targeting ZEB2. -target gene hsa-mir-1290 "Squamous Cell Carcinoma, Esophageal" 26653554 "Taken together, our findings suggested that miR-1290 functions as a tumor oncogene in the progression of ESCC by targeting NFIX." -target gene hsa-mir-30b Osteoarthritis 26653555 "In conclusion, miR-30b was involved in the process of OA, and it probably functioned through its target gene ERG." -target gene hsa-mir-130b Glioma 26653558 "In conclusion, miR-130b is an independent prognostic biomarker for indicating survival of glioma patients and promotes glioma cell migration and invasion by targeting PPAR¦Ã." -target gene hsa-mir-193a Lung Neoplasms 26655272 "Overall, we concluded that UCA1 functions as an oncogene in NSCLC, acting mechanistically by upregulating ERBB4 in part through 'spongeing' miR-193a-3p." -target gene hsa-mir-127 Neoplasms [unspecific] 26655997 "Restoration of miR-127-3p and miR-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1, GLE1 and PDIA6." -target gene hsa-mir-376a Neoplasms [unspecific] 26655997 "Restoration of miR-127-3p and miR-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1, GLE1 and PDIA6." -target gene hsa-mir-142 "Carcinoma, Breast" 26657485 "microRNA miR-142-3p Inhibits Breast Cancer Cell Invasiveness by Synchronous Targeting of WASL, Integrin Alpha V, and Additional Cytoskeletal Elements. HrC-9698" -target gene hsa-mir-31 Lung Neoplasms 26657862 Our study distinguishes miR-31 as a driver of lung tumorigenesis that promotes mutant KRAS-mediated oncogenesis and reveals that miR-31 directly targets and reduces expression of negative regulators of RAS/MAPK signaling. -target gene hsa-mir-31 Neoplasms [unspecific] 26663584 "We identified VAV3, a regulator of actin remodeling and MRTF-A activity, as a miR-31 target." -target gene hsa-mir-34a Lung Neoplasms 26667302 "Therefore, we propose that AXL is autoregulated by miR-34a in a feedback loop; this may provide a novel opportunity for developing AXL-targeted anticancer therapies." -target gene hsa-mir-29 "Squamous Cell Carcinoma, Lung" 26676674 Elucidation of the novel lung SCC molecular pathways and targets regulated by tumor-suppressive miR-29s will provide new insights into the potential mechanisms of oncogenesis and metastasis of the disease. -target gene hsa-mir-203 Glioma 26678661 "These data demonstrate that miR-203 potentially controls DNA damage repair via the PI3K/AKT and JAK/STAT3 pathways and may collectively contribute to the modulation of radiation sensitivity in MG cells by inhibiting DNA damage repair, prosurvival signaling, and epithelium-mesenchyme transition. Taken together, these findings demonstrate that miR-203 could be a target for overcoming the radiation resistance of GBM." -target gene hsa-mir-26b Osteosarcoma 26681033 "miR- 26b may inhibit osteosarcoma cell proliferation, migration, and invasion by regulating PFKFB3 protein expression.miR-26b may have a tumor suppressor role in tumor occurrence and development." -target gene hsa-mir-145 Glioblastoma 26681767 ISO attenuated SOX2 expression by specific induction of miR-145 -target gene hsa-mir-494 Neoplasms [unspecific] 26686085 the regulatory effect of p100 on PTEN expression is mediated by its downregulation of miR-494 as a result of the inactivation of extracellular signal-regulated kinase 2 -target gene hsa-mir-15a Neoplasms [unspecific] 26686086 In vivo inhibition of a PPARγ-regulated miR-15a/angiopoietin-1 pathway blocked increased angiogenesis and MSC expansion. -target gene hsa-mir-27a Neoplasms [unspecific] 26687066 "Importantly, we find that Six1 expression leads to marked resistance to therapies targeting the p53-MDM2 interaction. Thus, we identify a competitive mechanism of p53 regulation, which may have consequences for drugs aimed at reinstating p53 function in tumours." -target gene hsa-mir-21 Multiple Myeloma 26687742 "STAT3 and hsa-miR-125b, PIAS3 and hsa-miR-21 respectively formed self adaptation feedback regulations." -target gene hsa-mir-155 Asthma 26693910 MicroRNA Expression Is Altered in an Ovalbumin-Induced Asthma Model and Targeting miR-155 with Antagomirs Reveals Cellular Specificity. -target gene hsa-mir-155 "Squamous Cell Carcinoma, Head and Neck" 26694378 MicroRNA-Target Network Inference and Local Network Enrichment Analysis Identify Two microRNA Clusters with Distinct Functions in Head and Neck Squamous Cell Carcinoma. -target gene hsa-mir-106a "Squamous Cell Carcinoma, Head and Neck" 26694379 MicroRNA-Target Network Inference and Local Network Enrichment Analysis Identify Two microRNA Clusters with Distinct Functions in Head and Neck Squamous Cell Carcinoma. -target gene hsa-mir-125b "Squamous Cell Carcinoma, Head and Neck" 26694379 MicroRNA-Target Network Inference and Local Network Enrichment Analysis Identify Two microRNA Clusters with Distinct Functions in Head and Neck Squamous Cell Carcinoma. -target gene hsa-mir-15b "Squamous Cell Carcinoma, Head and Neck" 26694379 MicroRNA-Target Network Inference and Local Network Enrichment Analysis Identify Two microRNA Clusters with Distinct Functions in Head and Neck Squamous Cell Carcinoma. -target gene hsa-mir-193b "Squamous Cell Carcinoma, Head and Neck" 26694379 MicroRNA-Target Network Inference and Local Network Enrichment Analysis Identify Two microRNA Clusters with Distinct Functions in Head and Neck Squamous Cell Carcinoma. -target gene hsa-mir-20b "Squamous Cell Carcinoma, Head and Neck" 26694379 MicroRNA-Target Network Inference and Local Network Enrichment Analysis Identify Two microRNA Clusters with Distinct Functions in Head and Neck Squamous Cell Carcinoma. -target gene hsa-mir-548b "Squamous Cell Carcinoma, Head and Neck" 26694379 MicroRNA-Target Network Inference and Local Network Enrichment Analysis Identify Two microRNA Clusters with Distinct Functions in Head and Neck Squamous Cell Carcinoma. -target gene hsa-mir-582 "Squamous Cell Carcinoma, Head and Neck" 26694379 MicroRNA-Target Network Inference and Local Network Enrichment Analysis Identify Two microRNA Clusters with Distinct Functions in Head and Neck Squamous Cell Carcinoma. -target gene hsa-mir-9-1 "Squamous Cell Carcinoma, Head and Neck" 26694379 MicroRNA-Target Network Inference and Local Network Enrichment Analysis Identify Two microRNA Clusters with Distinct Functions in Head and Neck Squamous Cell Carcinoma. -target gene hsa-mir-9-2 "Squamous Cell Carcinoma, Head and Neck" 26694379 MicroRNA-Target Network Inference and Local Network Enrichment Analysis Identify Two microRNA Clusters with Distinct Functions in Head and Neck Squamous Cell Carcinoma. -target gene hsa-mir-27b Diabetic Retinopathy 26696637 "The authors assessed 155 baseline or DR progressors and 145 control samples (selected from 3,326 study participants) for a panel of 29 candidate miRNAs that were based on previous studies related to diabetes and myocardial infarction. They identified miR-27b and miR-320a as being significantly and independently associated with high DR risk. Complementing this analysis, they also elucidated the potential mechanism using cultured human endothelial cells and identified antiangiogenic thrombospondin-1 as a common target of these two miRNAs." -target gene hsa-mir-320a Diabetic Retinopathy 26696637 "The authors assessed 155 baseline or DR progressors and 145 control samples (selected from 3,326 study participants) for a panel of 29 candidate miRNAs that were based on previous studies related to diabetes and myocardial infarction. They identified miR-27b and miR-320a as being significantly and independently associated with high DR risk. Complementing this analysis, they also elucidated the potential mechanism using cultured human endothelial cells and identified antiangiogenic thrombospondin-1 as a common target of these two miRNAs." -target gene hsa-mir-155 "Carcinoma, Nasopharyngeal" 26698246 This study found that aberrant miR-155 expression driven by LMP1 can modulate radio-sensitivity of the NPC cell at least partly through targeting UBQLN1. -target gene hsa-mir-705 Osteoporosis 26700816 "Mechanistically, TNF-¦Á activated NF-¦ÊB pathway to promote microRNA-705 expression, which function as a repressor of FoxO1 through post-transcriptional regulation." -target gene hsa-mir-21 Glioma 26701969 "These findings suggest that miR-21 is linked to glioma angiogenesis,that miR-21 is unlikely to regulate PTEN, and that miR-21-positive tumor cells do not possess stem cell characteristics." -target gene hsa-mir-218 Iron Metabolism Disease 26703568 "Taken together, our results show that miR-218 inhibits erythroid differentiation and alters iron metabolism by targeting ALAS2 in K562 cells." -target gene hsa-mir-125b "Carcinoma, Hepatocellular" 26704017 miR-125b has been reported to down-regulate SIRT7 by binding to its 3'UTR -target gene hsa-mir-1275 Lymphoma 26705180 "MiR-664b-5p, miR-1275, miR-4739, miR-4736 and miR-504-5p may become an important indicator in the differentiation ALK-negative anaplastic large cell lymphoma from CD30-positive peripheral T cell lymphoma (not otherwise specified).MiR-4739, miR-4736 and miR-1275 may play important role in pathogenesis of negative-anaplastic large cell lymphoma by target genes: TNFRSF8 and TMOD1." -target gene hsa-mir-4736 Lymphoma 26705180 "MiR-664b-5p, miR-1275, miR-4739, miR-4736 and miR-504-5p may become an important indicator in the differentiation ALK-negative anaplastic large cell lymphoma from CD30-positive peripheral T cell lymphoma (not otherwise specified).MiR-4739, miR-4736 and miR-1275 may play important role in pathogenesis of negative-anaplastic large cell lymphoma by target genes: TNFRSF8 and TMOD1." -target gene hsa-mir-4739 Lymphoma 26705180 "MiR-664b-5p, miR-1275, miR-4739, miR-4736 and miR-504-5p may become an important indicator in the differentiation ALK-negative anaplastic large cell lymphoma from CD30-positive peripheral T cell lymphoma (not otherwise specified).MiR-4739, miR-4736 and miR-1275 may play important role in pathogenesis of negative-anaplastic large cell lymphoma by target genes: TNFRSF8 and TMOD1." -target gene hsa-mir-504 Lymphoma 26705180 "MiR-664b-5p, miR-1275, miR-4739, miR-4736 and miR-504-5p may become an important indicator in the differentiation ALK-negative anaplastic large cell lymphoma from CD30-positive peripheral T cell lymphoma (not otherwise specified).MiR-4739, miR-4736 and miR-1275 may play important role in pathogenesis of negative-anaplastic large cell lymphoma by target genes: TNFRSF8 and TMOD1." -target gene hsa-mir-664b Lymphoma 26705180 "MiR-664b-5p, miR-1275, miR-4739, miR-4736 and miR-504-5p may become an important indicator in the differentiation ALK-negative anaplastic large cell lymphoma from CD30-positive peripheral T cell lymphoma (not otherwise specified).MiR-4739, miR-4736 and miR-1275 may play important role in pathogenesis of negative-anaplastic large cell lymphoma by target genes: TNFRSF8 and TMOD1." -target gene hsa-mir-106b Liver Transplant Rejection 26707312 "These results suggest that miR-18b, miR-340, and miR-106b, which regulate the expression of specific immunophenotypes, can be used as potential biomarkers to identify long-term stable liver transplant recipients from recipients with acute rejection." -target gene hsa-mir-18b Liver Transplant Rejection 26707312 "These results suggest that miR-18b, miR-340, and miR-106b, which regulate the expression of specific immunophenotypes, can be used as potential biomarkers to identify long-term stable liver transplant recipients from recipients with acute rejection." -target gene hsa-mir-340 Liver Transplant Rejection 26707312 "These results suggest that miR-18b, miR-340, and miR-106b, which regulate the expression of specific immunophenotypes, can be used as potential biomarkers to identify long-term stable liver transplant recipients from recipients with acute rejection." -target gene hsa-mir-205 Osteosarcoma 26708425 "In conclusion, our study suggested that miR-205 may function as a tumor suppressor via targeting TGF-¦Á in OS, and the abnormal expression of miR-205 might be a key factor in OS progression." -target gene hsa-mir-363 Gastric Neoplasms 26709677 MiR-363-3p showed low levels in GC tissues and cells. Enforced expression of miR-363-3p inhibited cell growth and migration of GC cells and vice versa. NOTCH1 is the targeted gene of miR-363-3p. CONCLUSIONS MiR-363-3p plays a tumor suppressor role in GC. -target gene hsa-mir-135b "Carcinoma, Breast, Triple Negative" 26711213 "The expressions of miRNA-135b were higher in most triple-negative breast cancer cell lines than others. miRNA-135b could promote the proliferation,invasion and migration in triple-negative breast cancer cell lines MDA-MB-231 and MDA-MB-468, and APC was one of the target genes of miRNA- 135b by participating in the process of regulation." -target gene hsa-mir-199a Ovarian Neoplasms 26711828 "miR-199a regulates the sensitivity of ovarian cancer cells to cisplatin through modulating expression of mTOR, and involves in the cisplatin resistance process of ovarian cancer cells." -target gene hsa-mir-125a Leukemia 26713860 miR-125a suppressed Zbtb7a expression through its direct binding to the Zbtb7a-3'UTR. -target gene hsa-mir-125a Neoplasms [unspecific] 26713860 miR-125a suppressed Zbtb7a expression through its direct binding to the Zbtb7a-3'UTR. -target gene hsa-mir-150 "Carcinoma, Cervical" 26715362 "Taken together, our data demonstrated that elevated miR-150 targets FOXO4 expression and therefore regulates multiple genes expression, resulting in cervical cancer cell growth and survival." -target gene hsa-mir-663 Glioblastoma 26717894 "MicroRNA-663 inhibits the proliferation, migration and invasion of glioblastoma cells via targeting TGF-¦Â1." -target gene hsa-mir-92a Intracranial Aneurysm 26718427 "In conclusion, our research demonstrated that miR-92a and KLF2 were negative correlation in intracranial aneurysm model, and miR-92a could directly target KLF2 in endothelial cells through complementary sequence of 3'UTR region." -target gene hsa-mir-331 Colorectal Carcinoma 26718987 "Overall, we identified that miR-331-3p is underexpressed in CRC and contributes to cell growth regulation by targeting HER2 through activating the PI3K/Akt and ERK1/2 signaling pathways." -target gene hsa-mir-129 Breast Neoplasms 26720492 The miR-129-5p/HMGB1 axis can regulate irradiation-induced autophagy in breast cancer and might be an important pathway in regulating radiosensitivity of breast cancer cells. -target gene hsa-mir-194 "Carcinoma, Hepatocellular" 26722431 MicroRNA-194 acts as a prognostic marker and inhibits proliferation in hepatocellular carcinoma by targeting MAP4K4. -target gene hsa-mir-592 "Carcinoma, Hepatocellular" 26722432 MicroRNA-592 targets DEK oncogene and suppresses cell growth in the hepatocellular carcinoma cell line HepG2. -target gene hsa-mir-214 Glioma 26722446 "In summary, our data indicate that miR-214 may function as tumor suppressor in glioma by targeting PCBP2." -target gene hsa-mir-34c "Carcinoma, Hepatocellular" 26722462 "miR-34c-3p inhibits cell proliferation, migration and invasion of hepatocellular carcinoma by targeting MARCKS." -target gene hsa-mir-204 "Carcinoma, Esophageal" 26722467 miR-204 inhibits invasion and epithelial-mesenchymal transition by targeting FOXM1 in esophageal cancer. -target gene hsa-mir-140 Lung Neoplasms 26722475 "MicroRNA-140-3p inhibits proliferation, migration and invasion of lung cancer cells by targeting ATP6AP2." -target gene hsa-mir-365 Osteosarcoma 26728377 miR-365 could inhibit the proliferation and promote the apoptosis in SOSP-9607 osteosarcoma cells probably by mediating the expression of KRAS. -target gene hsa-let-7b Retinoblastoma 26730174 "Several critical miRNAs were identified in RB progression.Hsa-miR-373 might regulate RB invasion and metastasis, hsa-miR-181a might involve in the CDKN1B-mediated cell cycle pathway, and hsa-miR-125b and hsa-let-7b might serve as tumor suppressors by coregulating CDK6, CDC25A, and LIN28A. The miRNAs hsa-miR-25, hsa-miR-18a, and hsa-miR-20a might exert their function by coregulating BCL2L1." -target gene hsa-mir-125b Retinoblastoma 26730174 "Several critical miRNAs were identified in RB progression.Hsa-miR-373 might regulate RB invasion and metastasis, hsa-miR-181a might involve in the CDKN1B-mediated cell cycle pathway, and hsa-miR-125b and hsa-let-7b might serve as tumor suppressors by coregulating CDK6, CDC25A, and LIN28A. The miRNAs hsa-miR-25, hsa-miR-18a, and hsa-miR-20a might exert their function by coregulating BCL2L1." -target gene hsa-mir-18a Retinoblastoma 26730174 "Several critical miRNAs were identified in RB progression.Hsa-miR-373 might regulate RB invasion and metastasis, hsa-miR-181a might involve in the CDKN1B-mediated cell cycle pathway, and hsa-miR-125b and hsa-let-7b might serve as tumor suppressors by coregulating CDK6, CDC25A, and LIN28A. The miRNAs hsa-miR-25, hsa-miR-18a, and hsa-miR-20a might exert their function by coregulating BCL2L1." -target gene hsa-mir-20a Retinoblastoma 26730174 "Several critical miRNAs were identified in RB progression.Hsa-miR-373 might regulate RB invasion and metastasis, hsa-miR-181a might involve in the CDKN1B-mediated cell cycle pathway, and hsa-miR-125b and hsa-let-7b might serve as tumor suppressors by coregulating CDK6, CDC25A, and LIN28A. The miRNAs hsa-miR-25, hsa-miR-18a, and hsa-miR-20a might exert their function by coregulating BCL2L1." -target gene hsa-mir-25 Retinoblastoma 26730174 "Several critical miRNAs were identified in RB progression.Hsa-miR-373 might regulate RB invasion and metastasis, hsa-miR-181a might involve in the CDKN1B-mediated cell cycle pathway, and hsa-miR-125b and hsa-let-7b might serve as tumor suppressors by coregulating CDK6, CDC25A, and LIN28A. The miRNAs hsa-miR-25, hsa-miR-18a, and hsa-miR-20a might exert their function by coregulating BCL2L1." -target gene hsa-mir-373 Retinoblastoma 26730174 "Several critical miRNAs were identified in RB progression.Hsa-miR-373 might regulate RB invasion and metastasis, hsa-miR-181a might involve in the CDKN1B-mediated cell cycle pathway, and hsa-miR-125b and hsa-let-7b might serve as tumor suppressors by coregulating CDK6, CDC25A, and LIN28A. The miRNAs hsa-miR-25, hsa-miR-18a, and hsa-miR-20a might exert their function by coregulating BCL2L1." -target gene hsa-mir-31 "Carcinoma, Thyroid, Papillary" 26731986 Down regulation of miR-31 contributed to the malignant progression of papillary thyroid carcinoma cells by targeting HuR. -target gene hsa-mir-935 "Carcinoma, Gastric, Signet Ring Cell" 26742429 miR-935 suppresses gastric signet ring cell carcinoma tumorigenesis by targeting Notch1 expression. -target gene hsa-mir-193a "Carcinoma, Esophageal" 26743123 miR-193a-3p regulation of chemoradiation resistance in oesophageal cancer cells via the PSEN1 gene. -target gene hsa-mir-320 Inflammatory Bowel Diseases 26752466 Exogenous miR-320 transfection in HT29 cells leads to a significant decrease of NOD2 expression -target gene hsa-mir-19 Gastric Neoplasms 26762410 "MEF2D is a direct target of miR-19, which was found to be decreased in gastric cancer clinical specimens." -target gene hsa-mir-4480 Macular Degeneration 26765636 Functional single nucleotide polymorphism in IL-17A 3' untranslated region is targeted by miR-4480 in vitro and may be associated with age-related macular degeneration. -target gene hsa-mir-215 Glioma 26766590 MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B. -target gene hsa-mir-328 "Carcinoma, Esophageal" 26773497 MiR-328 suppresses the survival of esophageal cancer cells by targeting PLCE1. -target gene hsa-mir-367 "Squamous Cell Carcinoma, Esophageal" 26777997 MiR-367 is a potential biomarker for ESCC and may act as an oncogene in regulating ESCC development. -target gene hsa-mir-155 Ovarian Neoplasms 26779627 miR-155 mediates cisplatin-induced apoptosis by targeting XIAP in ovarian cancer -target gene hsa-mir-205 "Aortic Aneurysm, Abdominal" 26781079 a significant downregulation of LRP1 protein expression was shown in miR-205-overexpressing VSMCs -target gene hsa-mir-96 Cardiomegaly 26782545 miR-96 inhibits cardiac hypertrophy by targeting growth factor receptor-bound 2. -target gene hsa-mir-141 "Carcinoma, Hepatocellular" 26790956 MiR-141 suppression may cause aberrant expression of SPAG9 and promote HCC tumorigenesis via JNK pathway. -target gene hsa-mir-148a Lupus Nephritis 26791485 miR-148a-3p overexpression contributes to glomerular cell proliferation by targeting PTEN in lupus nephritis. -target gene hsa-mir-200a "Carcinoma, Renal Cell" 26797273 MicroRNA-200a-3p suppresses tumor proliferation and induces apoptosis by targeting SPAG9 in renal cell carcinoma. -target gene hsa-mir-31 Glioma 26801671 the suppressive effect of miR-31 on glioma cell migration and invasion is p21-dependent -target gene hsa-mir-29a "Carcinoma, Breast" 26802653 "inhibitors of microRNA-29a promote apoptosis through upregulation of HSP60 level and downregulation of HSP27, HSP40, HSP70, and HSP90 levels" -target gene hsa-mir-142 Neoplasms [unspecific] 26805039 Our observations suggest that miR-142-3p functioned as a tumor suppressor by targeting CDC25C. -target gene hsa-mir-625 Breast Neoplasms 26806308 miR-625 suppresses cell proliferation and migration by targeting HMGA1 in breast cancer. -target gene hsa-mir-143 "Squamous Cell Carcinoma, Esophageal" 26806810 MiR-143 inhibits tumor cell proliferation and invasion by targeting STAT3 in esophageal squamous cell carcinoma. -target gene hsa-mir-34c Prostate Neoplasms 26808578 Functional analysis revealed that miR-34c and miR-297 overexpression down-regulated AR expression and inhibited the expression of downstream AR targets -target gene hsa-mir-21 Colorectal Carcinoma 26811607 "MicroRNA-21 increases the levels of IL-10 and prostaglandin E2, which suppress antitumor T-cell-mediated adaptive immunity" -target gene hsa-mir-133a Dengue Virus Infection 26818704 miRNA-133a regulates DENV replication possibly through the modulation of a host factor such as PTB. Further investigations are needed to verify whether miRNA-133a has an anti-DENV effect in vivo. -target gene hsa-mir-33a Japanese Encephalitis Virus Infection 26819305 MicroRNA-33a-5p Modulates Japanese Encephalitis Virus Replication by Targeting Eukaryotic Translation Elongation Factor 1A1. -target gene hsa-mir-519 Gastric Neoplasms 26819420 MiR-may inhibit the gastric cancer cell activity through suppression of HuR expression. -target gene hsa-mir-187 Colorectal Carcinoma 26820227 "MicroRNA-187, a downstream effector of TGF¦Â pathway, suppresses Smad-mediated epithelial-mesenchymal transition in colorectal cancer." -target gene hsa-mir-142 Fever 26825461 "RBM3 regulates temperature sensitive miR-142-5p and miR-143 (thermomiRs), which target immune genes and control fever." -target gene hsa-mir-143 Fever 26825461 "RBM3 regulates temperature sensitive miR-142-5p and miR-143 (thermomiRs), which target immune genes and control fever." -target gene hsa-mir-26b "Carcinoma, Lung, Non-Small-Cell" 26827826 MicroRNA-26b suppresses the metastasis of non-small cell lung cancer by targeting MIEN1 via NF-¦ÊB/MMP-9/VEGF pathways. -target gene hsa-mir-489 Breast Neoplasms 26828271 GSE1 negative regulation by miR-489-5p promotes breast cancer cell proliferation and invasion. -target gene hsa-mir-20a Breast Neoplasms 26829385 MiR-20a and miR-20b negatively regulate autophagy by targeting RB1CC1/FIP200 in breast cancer cells. -target gene hsa-mir-20b Breast Neoplasms 26829385 MiR-20a and miR-20b negatively regulate autophagy by targeting RB1CC1/FIP200 in breast cancer cells. -target gene hsa-mir-205 Neoplasms [unspecific] 26831618 "This alteration inverts relative expression levels of ZEB1 and its antagonizing microRNAs, miR-205 and miR-200c" -target gene hsa-mir-7 "Carcinoma, Hepatocellular" 26831666 miR-7 suppressed the expression of VDAC1 -target gene hsa-mir-505 "Carcinoma, Endometrial" 26832151 "Taken together, this study demonstrates that miR-505 acts as tumor suppressor in EC by regulating TGF-¦Á." -target gene hsa-mir-103 Atherosclerosis 26837267 Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4. -target gene hsa-mir-497 Colorectal Carcinoma 26840372 Thus our results provide evidence that miR-497 might function as a metastasis suppressor in CRC. Targeting miR-497 may provide a strategy for blocking its metastasis. -target gene hsa-mir-302a Breast Neoplasms 26842910 Our results indicate that miR-302 cooperatively sensitizes breast cancer cells to adriamycin via suppressing P-glycoprotein by targeting MEKK1 of ERK pathway. miR-302 gene cluster may be a potential target for reversing P-gp-mediated chemoresistance in breast cancer. -target gene hsa-mir-302b Breast Neoplasms 26842910 Our results indicate that miR-302 cooperatively sensitizes breast cancer cells to adriamycin via suppressing P-glycoprotein by targeting MEKK1 of ERK pathway. miR-302 gene cluster may be a potential target for reversing P-gp-mediated chemoresistance in breast cancer. -target gene hsa-mir-302c Breast Neoplasms 26842910 Our results indicate that miR-302 cooperatively sensitizes breast cancer cells to adriamycin via suppressing P-glycoprotein by targeting MEKK1 of ERK pathway. miR-302 gene cluster may be a potential target for reversing P-gp-mediated chemoresistance in breast cancer. -target gene hsa-mir-302d Breast Neoplasms 26842910 Our results indicate that miR-302 cooperatively sensitizes breast cancer cells to adriamycin via suppressing P-glycoprotein by targeting MEKK1 of ERK pathway. miR-302 gene cluster may be a potential target for reversing P-gp-mediated chemoresistance in breast cancer. -target gene hsa-mir-26b "Carcinoma, Hepatocellular" 26843134 MicroRNA-26b Enhances the Radiosensitivity of Hepatocellular Carcinoma Cells by Targeting EphA2. -target gene hsa-let-7 Myocardial Ischemic-Reperfusion Injury 26844226 "After Myocardial Ischemia-Reperfusion, miR-29a, and Let7 Could Affect Apoptosis through Regulating IGF-1." -target gene hsa-mir-15a Myasthenia Gravis 26845678 MiR-15a contributes abnormal immune response in myasthenia gravis by targeting CXCL10. -target gene hsa-mir-182 "Adenocarcinoma, Endometrial" 26847831 miR-182 expression is epigenetically increased leading to decreased CUL5 expression and increased cellular proliferation. -target gene hsa-mir-34a Colon Neoplasms 26849305 miR-34a directly suppresses Numb in early-stage colon cancer stem cells (CCSCs) -target gene hsa-mir-873 Ovarian Neoplasms 26850595 overexpression of miR-873 increased the sensitivity of ovarian cancer cells to cisplatin and paclitaxel by targeting MDR1 expression. -target gene hsa-mir-320a Ischemia-Reperfusion Injury 26850728 intrathecal infusion of miR-320a mimic attenuated IR-induced lower limb motor function deficits -target gene hsa-mir-1 "Carcinoma, Nasopharyngeal" 26852690 "miR-1, regulated by LMP1, suppresses tumour growth and metastasis by targeting K-ras in nasopharyngeal carcinoma." -target gene hsa-mir-504 Glioma 26854715 "A tumor-suppressive microRNA, miR-504, inhibits cell proliferation and promotes apoptosis by targeting FOXP1 in human glioma." -target gene hsa-mir-26a Osteoarthritis 26854724 MicroRNA-26a-5p regulates the expression of inducible nitric oxide synthase via activation of NF-¦ÊB pathway in human osteoarthritis chondrocytes. -target gene hsa-mir-133b Glioblastoma 26857280 "several miRNAs (miR-133b, miR-30b-3p, miR-145-5p, and miR-146a-5p) targeting EGFR" -target gene hsa-mir-145 Glioblastoma 26857280 "several miRNAs (miR-133b, miR-30b-3p, miR-145-5p, and miR-146a-5p) targeting EGFR" -target gene hsa-mir-146a Glioblastoma 26857280 "several miRNAs (miR-133b, miR-30b-3p, miR-145-5p, and miR-146a-5p) targeting EGFR" -target gene hsa-mir-193b Glioblastoma 26857280 "microRNAs (miRNAs) (miR-193b-3p, miR-518b, miR-520f-3p, and miR-506-5p) targeting PDGFRB were downregulated" -target gene hsa-mir-30b Glioblastoma 26857280 "miRNAs (miR-133b, miR-30b-3p, miR-145-5p, and miR-146a-5p) targeting EGFR" -target gene hsa-mir-506 Glioblastoma 26857280 "microRNAs (miRNAs) (miR-193b-3p, miR-518b, miR-520f-3p, and miR-506-5p) targeting PDGFRB were downregulated" -target gene hsa-mir-518b Glioblastoma 26857280 "microRNAs (miRNAs) (miR-193b-3p, miR-518b, miR-520f-3p, and miR-506-5p) targeting PDGFRB were downregulated" -target gene hsa-mir-520f Glioblastoma 26857280 "microRNAs (miRNAs) (miR-193b-3p, miR-518b, miR-520f-3p, and miR-506-5p) targeting PDGFRB were downregulated" -target gene hsa-mir-17 Diabetes Mellitus 26858253 "In fact, miR-17 knockdown was able to mimic the IFNγ effects on TXNIP, whereas miR-17 overexpression blunted the cytokine effect." -target gene hsa-mir-146 "Carcinoma, Renal Cell" 26859141 "We identified novel target genes of dysregulated miRNAs, which are involved in the transition from primary RCC without metastases into tumors generating distant metastasis." -target gene hsa-mir-208a Myocardial Infarction 26861724 miR-208a can promote Ang II-induced cardiomyocyte apoptosis via negatively regulating NLK expression -target gene hsa-mir-92a "Carcinoma, Rectal" 26865277 Integrated genomic profiling identifies microRNA-92a regulation of IQGAP2 in locally advanced rectal cancer. -target gene hsa-mir-124 Viral Infectious Disease 26865716 "Our data show that microRNA targeting can be used to further increase the safety of an attenuated mengovirus, providing a basis for its development as an oncolytic platform." -target gene hsa-mir-125 Viral Infectious Disease 26865716 "Our data show that microRNA targeting can be used to further increase the safety of an attenuated mengovirus, providing a basis for its development as an oncolytic platform." -target gene hsa-mir-133 Viral Infectious Disease 26865716 "Our data show that microRNA targeting can be used to further increase the safety of an attenuated mengovirus, providing a basis for its development as an oncolytic platform." -target gene hsa-mir-142 Viral Infectious Disease 26865716 "Our data show that microRNA targeting can be used to further increase the safety of an attenuated mengovirus, providing a basis for its development as an oncolytic platform." -target gene hsa-mir-208 Viral Infectious Disease 26865716 "Our data show that microRNA targeting can be used to further increase the safety of an attenuated mengovirus, providing a basis for its development as an oncolytic platform." -target gene hsa-mir-499 Oral Neoplasms 26867589 This study describes the regulation of PDCD4 specifically in tonsil SCC by miR-499 and miR-21 and has documented the loss of PDCD4 in tonsil SCCs.These findings highlight the complex interplay between miRNAs and tumour suppressor gene regulation and suggest that PDCD4 loss may be an important step in tonsillar carcinogenesis. -target gene hsa-mir-486 Ovarian Neoplasms 26871282 "OLFM4 is downregulated by miR-486-5p, which contributes to ovarian cancer tumorigenesis." -target gene hsa-mir-23b Ovarian Neoplasms 26872615 Our findings show that miR-23b may inhibit ovarian cancer tumorigenesis and progression by downregulating CCNG1 and the expression of the relevant genes. MiR-23b is a potentially novel application for regulating ovarian carcinoma progression. -target gene hsa-mir-130b Colorectal Carcinoma 26873488 colorectal cancer -target gene hsa-mir-206 Breast Neoplasms 26879016 significantly negative correlation between miR-206 and Cx43 expression -target gene hsa-mir-503 Nephrotic Syndrome 26882816 "In this study, we determined that serum miR-503 was significantly decreased in NS children. MiR-503 contributes to the aberrant proliferation of RMCs by targeting cyclin E, which may represent potential diagnostic and prognostic biomarkers for idiopathic pediatric NS." -target gene hsa-mir-195 "Squamous Cell Carcinoma, Tongue" 26885901 Relationships between microRNA expressions and prognosis in patients with tongue squamous cell carcinoma and the mechanisms microRNA regulating tongue squamous cell carcinoma biological behavior. -target gene hsa-mir-26a "Squamous Cell Carcinoma, Tongue" 26885901 Relationships between microRNA expressions and prognosis in patients with tongue squamous cell carcinoma and the mechanisms microRNA regulating tongue squamous cell carcinoma biological behavior. -target gene hsa-mir-29b "Squamous Cell Carcinoma, Tongue" 26885901 Relationships between microRNA expressions and prognosis in patients with tongue squamous cell carcinoma and the mechanisms microRNA regulating tongue squamous cell carcinoma biological behavior. -target gene hsa-mir-34a "Squamous Cell Carcinoma, Tongue" 26885901 Relationships between microRNA expressions and prognosis in patients with tongue squamous cell carcinoma and the mechanisms microRNA regulating tongue squamous cell carcinoma biological behavior. -target gene hsa-mir-375 "Squamous Cell Carcinoma, Tongue" 26885901 Relationships between microRNA expressions and prognosis in patients with tongue squamous cell carcinoma and the mechanisms microRNA regulating tongue squamous cell carcinoma biological behavior. -target gene hsa-mir-199a Atrial Fibrillation 26888839 "miRNAs regulate the occurrence and development of AF. RFA can change the expression of miRNAs in AF patients, which may be important for reversing the electrical and structural remodeling and maintaining sinus rhythm after RFA.miRNAs, such as miR-30b-5p, miR-377-5p and miR-199a-3p/miR-199b-3p etc., might become the target markers for early diagnosis and intervention of AF in future." -target gene hsa-mir-199b Atrial Fibrillation 26888839 "miRNAs regulate the occurrence and development of AF. RFA can change the expression of miRNAs in AF patients, which may be important for reversing the electrical and structural remodeling and maintaining sinus rhythm after RFA.miRNAs, such as miR-30b-5p, miR-377-5p and miR-199a-3p/miR-199b-3p etc., might become the target markers for early diagnosis and intervention of AF in future." -target gene hsa-mir-30b Atrial Fibrillation 26888839 "miRNAs regulate the occurrence and development of AF. RFA can change the expression of miRNAs in AF patients, which may be important for reversing the electrical and structural remodeling and maintaining sinus rhythm after RFA.miRNAs, such as miR-30b-5p, miR-377-5p and miR-199a-3p/miR-199b-3p etc., might become the target markers for early diagnosis and intervention of AF in future." -target gene hsa-mir-377 Atrial Fibrillation 26888839 "miRNAs regulate the occurrence and development of AF. RFA can change the expression of miRNAs in AF patients, which may be important for reversing the electrical and structural remodeling and maintaining sinus rhythm after RFA.miRNAs, such as miR-30b-5p, miR-377-5p and miR-199a-3p/miR-199b-3p etc., might become the target markers for early diagnosis and intervention of AF in future." -target gene hsa-mir-122 Sepsis 26889043 These findings demonstrate that host cellular RNA and specific miRNAs are released into the circulation during polymicrobial sepsis and may function as extracellular mediators capable of promoting cfB production and AP activation through specific TLR7 and MyD88 signaling. -target gene hsa-mir-145 Sepsis 26889043 These findings demonstrate that host cellular RNA and specific miRNAs are released into the circulation during polymicrobial sepsis and may function as extracellular mediators capable of promoting cfB production and AP activation through specific TLR7 and MyD88 signaling. -target gene hsa-mir-146a Sepsis 26889043 These findings demonstrate that host cellular RNA and specific miRNAs are released into the circulation during polymicrobial sepsis and may function as extracellular mediators capable of promoting cfB production and AP activation through specific TLR7 and MyD88 signaling. -target gene hsa-mir-210 Sepsis 26889043 These findings demonstrate that host cellular RNA and specific miRNAs are released into the circulation during polymicrobial sepsis and may function as extracellular mediators capable of promoting cfB production and AP activation through specific TLR7 and MyD88 signaling. -target gene hsa-mir-34a Sepsis 26889043 These findings demonstrate that host cellular RNA and specific miRNAs are released into the circulation during polymicrobial sepsis and may function as extracellular mediators capable of promoting cfB production and AP activation through specific TLR7 and MyD88 signaling. -target gene hsa-mir-96 "Carcinoma, Lung, Non-Small-Cell" 26893673 "overexpression of miR-96 in NSCLC cells markedly decreased SAMD9 expression and cisplatin-induced apoptosis, and increased the cisplatin IC50" -target gene hsa-mir-451a Breast Neoplasms 26896688 "Over-expression of miR-451a can enhance the sensitivity of breast cancer cells to tamoxifen by regulating 14-3-3¦Æ, estrogen receptor ¦Á, and autophagy." -target gene hsa-mir-9 Diabetic Cardiomyopathies 26898797 Inhibition of miR-9 upregulates ELAVL1 expression and activates caspase-1. -target gene hsa-mir-34a Breast Neoplasms 26902416 LDHA was a direct target of miR-34a -target gene hsa-mir-27a Colorectal Carcinoma 26913609 miR-27a modulates a group of proteins involved in MHC class I cell surface exposure -target gene hsa-mir-193a Osteosarcoma 26913720 "MiR-193a-3p and miR-193a-5p suppress the metastasis of human osteosarcoma cells by down-regulating Rab27B and SRR, respectively." -target gene hsa-mir-21 Granular Corneal Dystrophy 26915797 "TGF-¦Â regulates TGFBIp expression in corneal fibroblasts via miR-21, miR-181a,and Smad signaling." -target gene hsa-mir-30a Breast Neoplasms 26918943 we linked miR-30a to increased expression of claudins -target gene hsa-mir-26b Prostate Neoplasms 26920049 MiR-26b inhibits autophagy by targeting ULK2 in prostate cancer cells. -target gene hsa-mir-137 Schizophrenia 26925706 MicroRNA-137 (miR-137) is a brain-enriched RNA with a critical role in regulating brain development and in mediating synaptic plasticity. -target gene hsa-mir-101 Breast Neoplasms 26927545 miR-101 inhibits the proliferation and migration of breast cancer cells via downregulating the expression of DNA methyltransferase 3a. -target gene hsa-mir-1227 Diabetic Nephropathy 26930277 "In conclusion, urinary exosomal miRNA content is altered in type II diabetic patients with DN. Deregulated miR-320c, which might have an impact on the TGF-¦Â-signaling pathway via targeting thrombospondin 1 (TSP-1) shows promise as a novel candidate marker for disease progression in type II DN that should be evaluated in future studies." -target gene hsa-mir-1234 Diabetic Nephropathy 26930277 "In conclusion, urinary exosomal miRNA content is altered in type II diabetic patients with DN. Deregulated miR-320c, which might have an impact on the TGF-¦Â-signaling pathway via targeting thrombospondin 1 (TSP-1) shows promise as a novel candidate marker for disease progression in type II DN that should be evaluated in future studies." -target gene hsa-mir-1915 Diabetic Nephropathy 26930277 "In conclusion, urinary exosomal miRNA content is altered in type II diabetic patients with DN. Deregulated miR-320c, which might have an impact on the TGF-¦Â-signaling pathway via targeting thrombospondin 1 (TSP-1) shows promise as a novel candidate marker for disease progression in type II DN that should be evaluated in future studies." -target gene hsa-mir-2861 Diabetic Nephropathy 26930277 "In conclusion, urinary exosomal miRNA content is altered in type II diabetic patients with DN. Deregulated miR-320c, which might have an impact on the TGF-¦Â-signaling pathway via targeting thrombospondin 1 (TSP-1) shows promise as a novel candidate marker for disease progression in type II DN that should be evaluated in future studies." -target gene hsa-mir-30d Diabetic Nephropathy 26930277 "In conclusion, urinary exosomal miRNA content is altered in type II diabetic patients with DN. Deregulated miR-320c, which might have an impact on the TGF-¦Â-signaling pathway via targeting thrombospondin 1 (TSP-1) shows promise as a novel candidate marker for disease progression in type II DN that should be evaluated in future studies." -target gene hsa-mir-30e Diabetic Nephropathy 26930277 "In conclusion, urinary exosomal miRNA content is altered in type II diabetic patients with DN. Deregulated miR-320c, which might have an impact on the TGF-¦Â-signaling pathway via targeting thrombospondin 1 (TSP-1) shows promise as a novel candidate marker for disease progression in type II DN that should be evaluated in future studies." -target gene hsa-mir-320c Diabetic Nephropathy 26930277 "In conclusion, urinary exosomal miRNA content is altered in type II diabetic patients with DN. Deregulated miR-320c, which might have an impact on the TGF-¦Â-signaling pathway via targeting thrombospondin 1 (TSP-1) shows promise as a novel candidate marker for disease progression in type II DN that should be evaluated in future studies." -target gene hsa-mir-371b Diabetic Nephropathy 26930277 "In conclusion, urinary exosomal miRNA content is altered in type II diabetic patients with DN. Deregulated miR-320c, which might have an impact on the TGF-¦Â-signaling pathway via targeting thrombospondin 1 (TSP-1) shows promise as a novel candidate marker for disease progression in type II DN that should be evaluated in future studies." -target gene hsa-mir-4270 Diabetic Nephropathy 26930277 "In conclusion, urinary exosomal miRNA content is altered in type II diabetic patients with DN. Deregulated miR-320c, which might have an impact on the TGF-¦Â-signaling pathway via targeting thrombospondin 1 (TSP-1) shows promise as a novel candidate marker for disease progression in type II DN that should be evaluated in future studies." -target gene hsa-mir-4739 Diabetic Nephropathy 26930277 "In conclusion, urinary exosomal miRNA content is altered in type II diabetic patients with DN. Deregulated miR-320c, which might have an impact on the TGF-¦Â-signaling pathway via targeting thrombospondin 1 (TSP-1) shows promise as a novel candidate marker for disease progression in type II DN that should be evaluated in future studies." -target gene hsa-mir-4778 Diabetic Nephropathy 26930277 "In conclusion, urinary exosomal miRNA content is altered in type II diabetic patients with DN. Deregulated miR-320c, which might have an impact on the TGF-¦Â-signaling pathway via targeting thrombospondin 1 (TSP-1) shows promise as a novel candidate marker for disease progression in type II DN that should be evaluated in future studies." -target gene hsa-mir-572 Diabetic Nephropathy 26930277 "In conclusion, urinary exosomal miRNA content is altered in type II diabetic patients with DN. Deregulated miR-320c, which might have an impact on the TGF-¦Â-signaling pathway via targeting thrombospondin 1 (TSP-1) shows promise as a novel candidate marker for disease progression in type II DN that should be evaluated in future studies." -target gene hsa-mir-6068 Diabetic Nephropathy 26930277 "In conclusion, urinary exosomal miRNA content is altered in type II diabetic patients with DN. Deregulated miR-320c, which might have an impact on the TGF-¦Â-signaling pathway via targeting thrombospondin 1 (TSP-1) shows promise as a novel candidate marker for disease progression in type II DN that should be evaluated in future studies." -target gene hsa-mir-6126 Diabetic Nephropathy 26930277 "In conclusion, urinary exosomal miRNA content is altered in type II diabetic patients with DN. Deregulated miR-320c, which might have an impact on the TGF-¦Â-signaling pathway via targeting thrombospondin 1 (TSP-1) shows promise as a novel candidate marker for disease progression in type II DN that should be evaluated in future studies." -target gene hsa-mir-6133 Diabetic Nephropathy 26930277 "In conclusion, urinary exosomal miRNA content is altered in type II diabetic patients with DN. Deregulated miR-320c, which might have an impact on the TGF-¦Â-signaling pathway via targeting thrombospondin 1 (TSP-1) shows promise as a novel candidate marker for disease progression in type II DN that should be evaluated in future studies." -target gene hsa-mir-638 Diabetic Nephropathy 26930277 "In conclusion, urinary exosomal miRNA content is altered in type II diabetic patients with DN. Deregulated miR-320c, which might have an impact on the TGF-¦Â-signaling pathway via targeting thrombospondin 1 (TSP-1) shows promise as a novel candidate marker for disease progression in type II DN that should be evaluated in future studies." -target gene hsa-mir-200b Cervical Neoplasms 26935796 miRâ€?00b was shown to inhibit the function of RhoE and suppress the EMT of cervical cancer -target gene hsa-mir-16 Atherosclerosis 26936421 miRâ€?6 is a direct negative regulator of PDCD4 in atherosclerosis. -target gene hsa-mir-19b Japanese Encephalitis Virus Infection 26937036 MicroRNA-19b-3p Modulates Japanese Encephalitis Virus-Mediated Inflammation via Targeting RNF11. -target gene hsa-mir-34a Complex Regional Pain Syndrome 26940669 We show that hsa-miR-34a is a negative regulator of CRHR1; overexpression of hsa-miR-34a in Jurkat cells resulted in reduction of CRH-mediated POMC expression. -target gene hsa-mir-1271 Pancreatic Neoplasms 26940738 "miR-1271 inhibits migration, invasion and epithelial-mesenchymal transition by targeting ZEB1 and TWIST1 in pancreatic cancer cells." -target gene hsa-mir-34a Sickle Cell Anemia 26940952 "miR-34a promoted cell differentiation supported by increased expression of KLF1, glycophorin A, and the erythropoietin receptor." -target gene hsa-mir-200c "Carcinoma, Renal Cell, Clear-Cell" 26941587 "miRNA-200c that could regulate COL5A2 and COL5A3, miRNA-15a that could regulate ATP6V0B and miRNA-155 may play key roles in ccRCC progression." -target gene hsa-mir-126 Leishmaniasis 26941729 Development of Th2 type specific immune response can be suppressed by binding of miR-135 and miR-126 miRNAs over the 3'-UTR region of GATA-3 transcription factor of Th2 specific CD4(+) T helper cells. -target gene hsa-mir-21 Oral Submucous Fibrosis 26943153 PDGF-BB Enhances the Proliferation of Cells in Human Orbital Fibroblasts by Suppressing PDCD4 Expression Via Up-Regulation of microRNA-21. -target gene hsa-mir-379 "Carcinoma, Hepatocellular" 26944318 MicroRNA-379-5p inhibits tumor invasion and metastasis by targeting FAK/AKT signaling in hepatocellular carcinoma. -target gene hsa-mir-133b Liver Neoplasms 26945106 miR-133b regulation of CTGF is a novel mechanism critical for the proliferation and migration of HCC cells and OC response. -target gene hsa-mir-33a Alcoholic Hepatitis 26945479 The relative expression of miR-33a and miR-144 correlated inversely with ABCA1 but not with ABCG1 protein levels. -target gene hsa-let-7c "Carcinoma, Lung, Non-Small-Cell" 26945572 "Also, let-7c directly targeted the 3'-untranslated regions of JMJD1A and EZH2." -target gene hsa-mir-183 "Adenocarcinoma, Lung" 26951513 overexpression of miR-183 in CSLCs decreased PTPN4 protein levels while inhibition of miR-183 increased PTPN4 protein levels. -target gene hsa-mir-183 Choriocarcinoma 26951513 overexpression of miR-183 in CSLCs decreased PTPN4 protein levels while inhibition of miR-183 increased PTPN4 protein levels. -target gene hsa-mir-130b Lung Fibrosis 26953888 miR-130b-3p Modulates Epithelial-Mesenchymal Crosstalk in Lung Fibrosis by Targeting IGF-1. -target gene hsa-mir-3162 Asthma 26959414 MiR-3162-3p Is a Novel MicroRNA That Exacerbates Asthma by Regulating ¦Â-Catenin. -target gene hsa-mir-30 Pancreatic Neoplasms 26965588 high expression of the miR-30 family modulated by CD133 promotes migratory and invasive abilities in CD133(+) pancreatic cancer cells. -target gene hsa-mir-30e "Carcinoma, Hepatocellular" 26966067 MiR-30e suppresses proliferation of hepatoma cells via targeting prolyl 4-hydroxylase subunit alpha-1 (P4HA1) mRNA. -target gene hsa-mir-125b Neoplasms [unspecific] 26966351 miR-125b acts as a tumor suppressor in chondrosarcoma cells by the sensitization to doxorubicin through direct targeting the ErbB2-regulated glucose metabolism. -target gene hsa-mir-138 "Leukemia, Myeloid, Chronic" 26967056 miR-138 in BCR-ABL tyrosine kinase -target gene hsa-mir-17 "Leukemia, Myeloid, Chronic" 26967056 "and miR-17, miR-19a, miR-17-92 cluster with MAPK/ERK proteins." -target gene hsa-mir-181a "Leukemia, Myeloid, Chronic" 26967056 "miR-155, miR-181a with SOS proteins;" -target gene hsa-mir-19a "Leukemia, Myeloid, Chronic" 26967056 "miR-155, miR-19a, with KRAS proteins; miR-19a with RAF1 protein;" -target gene hsa-mir-21 Endomyocardial Fibrosis 26968995 miR-21 specific degradation of Smad7 may decrease the inhibitory feedback regulation of TGF-β1/Smad signaling -target gene hsa-mir-198 Osteosarcoma 26970302 MicroRNA-198 inhibited tumorous behaviors of human osteosarcoma through directly targeting ROCK1. -target gene hsa-mir-31 Sepsis 26978146 Down-regulation of MicroRNA-31 in CD4+ T Cells Contributes to Immunosuppression in Human Sepsis by Promoting TH2 Skewing. -target gene hsa-mir-203 Gastric Neoplasms 26980572 MicroRNA-203 suppresses gastric cancer growth by targeting PIBF1/Akt signaling. -target gene hsa-mir-26a "Carcinoma, Renal Cell" 26983694 "two genes promoting metastasis, LOXL2 and PLOD2, were epigenetically regulated by tumor-suppressive microRNAs, miR-26a and miR-26b" -target gene hsa-mir-124 Alzheimer Disease 26984601 The activation of EPAC-Rap1 pathway was involved in the inhibition of miR-124 in hippocampus under hypoxia or Aβ insult. -target gene hsa-mir-122 Liver Neoplasms 26987776 Differential TGF¦Â pathway targeting by miR-122 in humans and mice affects liver cancer metastasis. -target gene hsa-mir-203 Essential Thrombocythemia 26990535 miR-203 and miR-221 regulate SOCS1 and SOCS3 in essential thrombocythemia. -target gene hsa-mir-221 Essential Thrombocythemia 26990535 miR-203 and miR-221 regulate SOCS1 and SOCS3 in essential thrombocythemia. -target gene hsa-let-7a Hirschsprung Disease 26991540 Our study demonstrates that the miR-24-1*/let-7a*-ARP2/3 complex-RAC isoforms pathway may represent a novel pathogenic mechanism for HSCR. -target gene hsa-mir-24 Hirschsprung Disease 26991540 Our study demonstrates that the miR-24-1*/let-7a*-ARP2/3 complex-RAC isoforms pathway may represent a novel pathogenic mechanism for HSCR. -target gene hsa-mir-145 Atherosclerosis 26992033 miR-145 modulates the phenotypic switch of VSMCs from a contractile to a proliferative state via KLF5 and MYOCD in atherosclerosis. -target gene hsa-mir-409 Osteosarcoma 26992637 MicroRNA-409-3p inhibits osteosarcoma cell migration and invasion by targeting catenin-¦Ä1. -target gene hsa-mir-16 Breast Neoplasms 26993770 miR-16 sensitizes breast cancer cells to Taxol through the suppression of IKBKB expression -target gene hsa-mir-200a Pterygium 26995143 Up-regulated miR-200a levels were positively correlated with and p53 protein expression -target gene hsa-mir-138 Cerebral Ischemia 26998035 The expression of Lcn-2 was inhibited by miR-138 mimics and enhanced by miR-138 inhibitors -target gene hsa-mir-27a "Leukemia, Myeloid, Acute" 27013583 "Overexpression of miR-424&27a, by targeting the 3'UTR of PLAG1, enhanced TRAIL sensitivity in AML cells." -target gene hsa-mir-26b Psoriasis 27015452 Psoriasis Skin Inflammation-Induced microRNA-26b Targets NCEH1 in Underlying Subcutaneous Adipose Tissue. -target gene hsa-mir-138 Osteosarcoma 27019355 MiR-138 Acts as a Tumor Suppressor by Targeting EZH2 and Enhances Cisplatin-Induced Apoptosis in Osteosarcoma Cells. -target gene hsa-mir-495 Prostate Neoplasms 27031291 MicroRNA-495 Regulates Migration and Invasion in Prostate Cancer Cells Via Targeting Akt and mTOR Signaling. -target gene hsa-mir-181a Breast Neoplasms 27033456 "miR-181a, already demonstrated to inhibit ABCG2 translation, was down-regulated by GNT, explaining translational induction." -target gene hsa-mir-140 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 27033573 miR-140-5p affects the migration and invasion of hypopharyngeal carcinoma cells by downregulating ADAM10 expression. -target gene hsa-mir-720 "Carcinoma, Breast, Triple Negative" 27039296 miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells. -target gene hsa-mir-130a Cervical Neoplasms 27040383 miR-130a accelerates cervical cancer cell proliferation by targeting the phosphatase and tensin homolog on chromosome 10 (PTEN) -target gene hsa-mir-192 Neoplasms [unspecific] 27041221 A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer. -target gene hsa-mir-143 Atopic Dermatitis 27048505 "The forced expression of microRNA-143 mimic blocked the IL-13-induced downregulation of filaggrin, loricrin, and involucrin in epidermal keratinocytes." -target gene hsa-mir-491 "Carcinoma, Hepatocellular" 27053618 "miR-491 inhibits the proliferation, invasion and migration of hepatocellular carcinoma cell via down-regulating TPX2 expression." -target gene hsa-mir-181b Osteosarcoma 27063156 microRNA-181b promotes migration and invasion of osteosarcoma cells by targeting N-myc downstream regulated gene 2. -target gene hsa-mir-155 Breast Neoplasms 27065318 miR-155 potently suppresses ErbB2 in breast cancer cells. -target gene hsa-mir-221 "Carcinoma, Thyroid, Papillary" 27077469 miR-221 exacerbated PTC by downregulating the expression of TIMP3. -target gene hsa-mir-192 Choriocarcinoma 27079614 microRNA-192 suppresses the expression of FXR and FXR target genes in vitro and in vivo. -target gene hsa-mir-143 Glioblastoma 27081712 "miRâ€?43 inhibited the proliferation, migration and invasion of the glioblastoma cells." -target gene hsa-mir-205 Gastric Neoplasms 27082508 "transfection with miRâ€?05, the epithelial marker CDH1 (E‑cadherin) was upregulated, and the mesenchymal markers CDH2 (N‑cadherin) and vimentin were suppressed." -target gene hsa-mir-30c Malignant Neoplasms [unspecific] 27085140 "miR-30c-1-3p altered basal and induced expression of cytochrome P450 3A4 (CYP3A4), a prototypical target gene of PXR." -target gene hsa-mir-4701 "Leukemia, Myeloid, Chronic" 27088512 miR-4701-5p directly targeted ST3GAL1 to reduce CML cells resistance to multiple chemotherapeutics in vitro and to convert tumor cells from adriamycin resistant to susceptible in vivo of mice. -target gene hsa-mir-124 Astrocytoma 27088547 "We showed that the repression of PIM1 in astrocytoma cancer cells by miR-124-3p suppressed proliferation, invasion, and aerobic glycolysis and promoted apoptosis." -target gene hsa-mir-3188 "Carcinoma, Nasopharyngeal" 27095304 miR-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR-p-PI3K/AKT-c-JUN. -target gene hsa-mir-144 Thyroid Neoplasms 27099512 "Transcription factor zinc finger E-box-binding homeobox 1 (ZEB1), as one of the key inducers of epithelial-mesenchymal transition, has been reported to be regulated by microRNA-144 and Bcl-2-associated athanogene 3" -target gene hsa-mir-206 Breast Neoplasms 27100732 Tbx3 is directly repressed by miR-206 -target gene hsa-mir-181b Breast Neoplasms 27102539 miR-181b-3p promotes epithelial-mesenchymal transition in breast cancer cells through Snail stabilization by directly targeting YWHAG. -target gene hsa-mir-155 Gastric Neoplasms 27113301 Target research on tumor biology characteristics of mir-155-5p regulation on gastric cancer cell. -target gene hsa-mir-200a Diabetes Mellitus 27121251 "Transfection with an miR-200a inhibitor increased Rheb protein levels and enhanced the feedback action on insulin receptor substrate-dependent insulin signaling, whereas transfection with an miR-200a mimic produced the opposite effects." -target gene hsa-mir-29b Thyroid Neoplasms 27125250 Functional assays confirmed PATZ1 as a target of miR-29b -target gene hsa-mir-126 Diabetes Mellitus 27127202 low miR-126 levels to be associated with markedly increased TF protein and TF-mediated thrombogenicity. -target gene hsa-mir-200a "Carcinoma, Gastric" 27144885 "Depleting endogenous Bart9 of SNU-719 induced a surged expression of miR-200a and miR-141, accompanied by decreased proliferative and invasive ability." -target gene hsa-mir-204 Pulmonary Hypertension 27149112 miR-204 diminution promotes RUNX2 up-regulation -target gene hsa-mir-183 Breast Neoplasms 27155522 "among MTUS1 targeting miRNAs, miR-183-5p was identified to be overexpressed in breast cancer and down-regulated in fibroadenoma tissues." -target gene hsa-mir-138 Breast Neoplasms 27155849 Only 8 APOBEC3B targeting miRNAs were observed to regulate the fusion transcript of which miR-34b-3p and miR-138-5p were found to be frequently downregulated in cancers suggesting miRNA-mediated deregulation of APOBEC3A expression in cancer patients harbouring this particular deletion polymorphism. -target gene hsa-mir-34b Breast Neoplasms 27155849 Only 8 APOBEC3B targeting miRNAs were observed to regulate the fusion transcript of which miR-34b-3p and miR-138-5p were found to be frequently downregulated in cancers suggesting miRNA-mediated deregulation of APOBEC3A expression in cancer patients harbouring this particular deletion polymorphism. -target gene hsa-mir-146a Infection [unspecific] 27156837 The in?vitro study suggested that transfected mmu-miR-146a-5p inhibitor upregulated TNF-¦Á and its target gene Traf6 in microglia following stimulation with A. cantonensis larval antigen. -target gene hsa-mir-135b Myxoid Liposarcoma 27157622 "Decreased THBS2 expression by miR-135b increases the total amount of matrix metalloproteinase 2 (MMP2) and influences cellular density and an extracellular matrix structure, thereby resulting in morphological change in tumor." -target gene hsa-mir-7 Parkinson Disease 27158385 The altered molecular expressions downstream of Bax and Sirt2 are also involved in miR-7 regulation of the MPP(+)-triggered neuronal apoptosis. -target gene hsa-mir-21 "Carcinoma, Basal Cell" 27159391 "Moreover, our results identify a miR21/GRHL3/D3 axis that reduces TH in the tumor microenvironment and has potential to be targeted as a therapeutic approach to BCC." -target gene hsa-mir-29 "Carcinoma, Hepatocellular" 27164857 "SETDB1 is a target of miR-29, which is frequently downregulated in human HCCs." -target gene hsa-mir-146a Breast Neoplasms 27175941 invasion activity in MDA-MB-231 breast cancer cells could be directly influenced by altering miR-146a expression. -target gene hsa-mir-195 Preeclampsia 27176145 miR-195 could directly target and suppress the expression of ActRIIB -target gene hsa-mir-143 Cervical Neoplasms 27177038 upregulation of miRâ€?43 expression reduced Bclâ€? expression and increased Bax expression in HeLa cells. -target gene hsa-mir-577 "Fatty Liver, Non-Alcoholic" 27179781 "NS5ATP6 regulated the expression of miR-577, which directly targeted and regulated FGF21." -target gene hsa-mir-105 Heart Failure 27185878 "miR-155 and miR-105, were found to modulate ANP production in human cardiomyocytes" -target gene hsa-mir-105 Hypertension 27185878 "miR-155 and miR-105, were found to modulate ANP production in human cardiomyocytes" -target gene hsa-mir-155 Heart Failure 27185878 "miR-155 and miR-105, were found to modulate ANP production in human cardiomyocytes" -target gene hsa-mir-155 Hypertension 27185878 "miR-155 and miR-105, were found to modulate ANP production in human cardiomyocytes" -target gene hsa-mir-425 Heart Failure 27185878 microRNA 425 (miR-425) was found to regulate ANP production -target gene hsa-mir-425 Hypertension 27185878 microRNA 425 (miR-425) was found to regulate ANP production -target gene hsa-mir-296 Ovarian Neoplasms 27186401 deregulated miR-296/S100A4 promotes tumor progression -target gene hsa-mir-23a "Leukemia, Myeloid, Acute" 27197200 overexpression of miR-23a decreased RKIP mRNA and protein expression -target gene hsa-mir-186 Myocardial Infarction 27205869 MicroRNA-186 promotes macrophage lipid accumulation and pro-inflammatory cytokine secretion by targeting cystathionine γ-lyase in THP-1 macrophages. -target gene hsa-mir-1 Heart Failure 27213338 miR-1 repressed the expression of gap junction protein α1 (GJA1) in VMC -target gene hsa-mir-19b Heart Failure 27213338 "a miR-19b inhibitor increased, while its mimics suppressed the expression of GJA1 in HL-1 cells." -target gene hsa-mir-31 "Adenocarcinoma, Lung" 27215092 MiR-31 Functions as a Tumor Suppressor in Lung Adenocarcinoma Mainly by Targeting HuR. -target gene hsa-mir-4271 Parkinson Disease 27217159 "hsa-miR-4271 was downregulated, which could influence EFNA3 translation" -target gene hsa-mir-21 Cervical Neoplasms 27220494 "MiR-21 overexpression decreases PTEN, increases p-Akt, and subsequently increases HIF-1α expression" -target gene hsa-mir-194 Breast Neoplasms 27221739 These findings demonstrate that nucleolin expression is down-regulated by miR-194 and miR-206 and upregulated by HuR -target gene hsa-mir-377 "Carcinoma, Hepatocellular" 27222047 IRX3 is a direct target of miR-377 -target gene hsa-mir-135b "Carcinoma, Endometrial" 27222184 MiR-135b promotes proliferation of endometrial carcinoma cells by targeting FOXO1. -target gene hsa-mir-21 "Carcinoma, Renal Cell" 27222255 miRâ€?1 was able to decrease the expression of CASC2 in 786‑O and A498 cells. -target gene hsa-mir-143 "Muscular Dystrophy, Duchenne" 27223470 miRNA-143 as a direct regulator of β-dystrobrevin expression -target gene hsa-mir-206 Pancreatic Neoplasms 27233476 "Mechanistically, the Nampt expression was independent of Kras and p16 status, but it was directly regulated by miR-206" -target gene hsa-mir-203 "Carcinoma, Lung, Non-Small-Cell" 27237033 Both miR-145 and miR-203 can directly target the 3'-untranslated region (3'-UTR) of SMAD3 -target gene hsa-mir-183 Neuroblastoma 27239679 Our results reveal the MCM complex to be a critical and directly regulated node within the miR-183 signaling network in MYCN-amplified neuroblastoma cells. -target gene hsa-mir-182 Glioma 27246830 miR-182-5p negatively regulated PCDH8 expression by directly targeting its 3'-untranslated region. -target gene hsa-mir-21 "Carcinoma, Hepatocellular" 27261510 "Here, we demonstrated that TNFα stimulation induced transcriptional downregulation of MSH2, a member of the mismatch repair family, via NF-κB-dependent miR-21 expression in hepatocytes." -target gene hsa-mir-374a "Carcinoma, Nasopharyngeal" 27270423 miR-374a direct targeting of CCND1 is modulated by tumor suppressor PDCD4 via suppressing pPI3K/pAKT/c-JUN signaling. -target gene hsa-mir-375 Prostate Neoplasms 27270433 The transcription factor YAP1 was found to be a direct target of miR-375 in prostate cancer. -target gene hsa-mir-17 Colon Neoplasms 27278684 miRâ€?7 overexpression led to the degradation of CYP7B1 mRNA expression in DLD1 cells. -target gene hsa-mir-218 Prostate Neoplasms 27278788 ectopic expression of these miRNAs suppressed PCa cell aggressiveness -target gene hsa-mir-26a Prostate Neoplasms 27278788 the lysyl oxidase-like 2 (LOXL2) gene was directly controlled by these tumor-suppressive miRNAs -target gene hsa-mir-26b Prostate Neoplasms 27278788 the lysyl oxidase-like 2 (LOXL2) gene was directly controlled by these tumor-suppressive miRNAs -target gene hsa-mir-29a Prostate Neoplasms 27278788 the lysyl oxidase-like 2 (LOXL2) gene was directly controlled by these tumor-suppressive miRNAs -target gene hsa-mir-29b Prostate Neoplasms 27278788 the lysyl oxidase-like 2 (LOXL2) gene was directly controlled by these tumor-suppressive miRNAs -target gene hsa-mir-29c Prostate Neoplasms 27278788 the lysyl oxidase-like 2 (LOXL2) gene was directly controlled by these tumor-suppressive miRNAs -target gene hsa-mir-23a "Carcinoma, Hepatocellular" 27279136 "the miR-23a mimic downregulated IFNγ-induced IRF-1 protein expression, while the miR-23a inhibitor increased IRF-1." -target gene hsa-mir-205 "Carcinoma, Lung, Non-Small-Cell" 27279345 overexpression of miRâ€?05 suppressed the expression of Smad4 -target gene hsa-let-7b Hypertension 27286171 micro-RNA Let-7b in post-transcriptional regulation -target gene hsa-mir-381 Tuberculosis 27296666 inhibition of miR-381-3p could reverse suppression of CD1c expression and promote T cell responses against BCG infection. -target gene hsa-mir-34a Diabetes Mellitus 27297797 "Subsequent overexpression of miR-34a inhibited Fndc5 expression, whereas blockade of miR-34a increased Fndc5 expression in myoblasts." -target gene hsa-mir-122 "Carcinoma, Hepatocellular" 27302319 "miR-122*, the passenger strand of miR-122, regulates the activity of p53 by targeting Mdm2." -target gene hsa-mir-183 Leukemia 27307158 FOXP3-induced miR-183 expression reduced β-TrCP mRNA stability and suppressed β-TrCP-mediated Sp1 degradation -target gene hsa-mir-200b Osteosarcoma 27307751 "miR-200b inhibits the proliferation, migration, and invasion of osteosarcoma cells, probably via the inhibition of ZEB1 expression." -target gene hsa-mir-200c Colorectal Carcinoma 27315529 ZEB1 expression was seen in connection with decreased miR-200c expression -target gene hsa-mir-134 Liver Fibrosis 27321552 Dieckol suppresses liver fibrosis via caspase activation and miR134 mediated JNK activation and NF-kB inhibition. -target gene hsa-mir-301a Osteosarcoma 27323075 Upregulated microRNA-301a in osteosarcoma promotes tumor progression by targeting CDC14A. -target gene hsa-mir-22 Vascular Disease [unspecific] 27325558 "miR-22-3p, had its binding site on the 3' UTR of VASH1 mRNA" -target gene hsa-mir-511 Alzheimer Disease 27334923 miR-511 is a functional regulator of FKBP5 and can contribute to neuronal differentiation. -target gene hsa-mir-335 "Carcinoma, Lung, Small-Cell" 27336605 miR-335 negatively regulated the MDR of WBP5 by targeting its 3'UTR -target gene hsa-mir-330 "Leukemia, Myeloid, Acute" 27341144 miR-330-5p is able to strongly silence TIM-3 expression (98.15% silencing) in HL-60 cell line (p = 0.0001). -target gene hsa-mir-128 Breast Neoplasms 27341528 AurkA suppressed the expression of miR-128 -target gene hsa-mir-103 Alzheimer Disease 27343180 "miR-103 and miR-107, regulate CDK5R1 expression and affect the levels of p35" -target gene hsa-let-7a Breast Neoplasms 27345399 let-7a and let-7b mimics attenuated p62-mediated MYC mRNA stabilization -target gene hsa-let-7b Breast Neoplasms 27345399 let-7a and let-7b mimics attenuated p62-mediated MYC mRNA stabilization -target gene hsa-mir-21 Anaplastic Astrocytoma 27347075 PTEN and miR-21 have been observed to form feedback loops. -target gene hsa-mir-25 Anaplastic Astrocytoma 27347075 "PTEN which is targeted by miR-21 and miR-106b, regulates miR-25 which in turn targets TP53" -target gene hsa-mir-21 Colorectal Carcinoma 27350731 PTEN is one of the direct target genes of miR-21. -target gene hsa-mir-144 Neurodegenerative Diseases [unspecific] 27370936 the expression of 14-3-3γ was upregulated following transfection with miR-7 and miR-144 mimics. -target gene hsa-mir-203 Neurodegenerative Diseases [unspecific] 27370936 miR-203 resulted in a down-regulation of 14-3-3θ transcript -target gene hsa-mir-7 Neurodegenerative Diseases [unspecific] 27370936 the expression of 14-3-3γ was upregulated following transfection with miR-7 and miR-144 mimics. -target gene hsa-mir-106a Lung Neoplasms 27372519 An inverse correlation of miR-106a and ULK1 expression was seen in lung adenocarcinoma. -target gene hsa-mir-155 Preeclampsia 27375191 These miRNAs have previously been linked to PE and are predicted to regulate members of the TGF-β pathway. -target gene hsa-mir-26a Preeclampsia 27375191 These miRNAs have previously been linked to PE and are predicted to regulate members of the TGF-β pathway. -target gene hsa-mir-204 Diabetes Mellitus 27384111 "Taken together, we have identified PERK as a novel target of miR-204 and show that miR-204 inhibits PERK signaling and increases ER stress-induced cell death, revealing for the first time a link between this miRNA and UPR." -target gene hsa-mir-145 Human Papilloma Virus Infection 27386862 KLF4 levels are increased in HPV-positive cells through a post-transcriptional mechanism involving E7-mediated suppression of cellular miR-145 -target gene hsa-mir-21 "Carcinoma, Renal Cell" 27388719 "in cells treated with AU-1, transient elevation of miR-34 leads to the downregulation of SIRT1, thereby miR-21 is freed from SIRT1-dependent suppression." -target gene hsa-mir-34 "Carcinoma, Renal Cell" 27388719 "in cells treated with AU-1, transient elevation of miR-34 leads to the downregulation of SIRT1, thereby miR-21 is freed from SIRT1-dependent suppression. Then, elevated miR-21 upregulates p21/Cip1 protein, followed by the suppression of miR-34 expression." -target gene hsa-mir-99a Atherosclerosis 27403035 MiR-99a inhibited the LPS-induced HUVECs inflammation via inhibition of the mTOR/NF-κB signal. -target gene hsa-mir-99a Cardiovascular Diseases [unspecific] 27403035 MiR-99a inhibited the LPS-induced HUVECs inflammation via inhibition of the mTOR/NF-κB signal. -target gene hsa-mir-133a Diabetes Mellitus 27411382 "Our results revealed that miR-133a mimic treatment improved the contractility of the diabetic rat's heart concomitant with upregulation of TH, cardiac NE, β-AR, and downregulation of TAT and plasma levels of NE." -target gene hsa-mir-145 Cardiovascular Diseases [unspecific] 27412561 miR-145 is involved in the anti-proliferation and anti-inflammation effects of aspirin on VSMCs by inhibiting the expression of CD40. -target gene hsa-mir-26a Retinoblastoma 27421000 "Beclin 1 is the target of miR-26a in human RB cell lines Y79 and WERi-RB-1, and miR-26a inhibits the expression of Beclin 1 by reducing its mRNA and protein levels." -target gene hsa-mir-20b Diabetic Retinopathy 27421659 "Transfection of miR-20b mimic in high glucose (HG)-treated human retinal endothelial cells (HRECs) increased miR-20b expression and decreased the expression level of VEGF mRNA, while transfection of miR-20b inhibitor in control HRECs reduced the miR-20b expression with a corresponding increase of VEGF mRNA." -target gene hsa-mir-1273g Hepatitis C Virus Infection 27423040 "Overexpression of miR-1273g-3p could inhibit translation of PTEN, increase the expression of α-SMA, Col1A1, and reduce apoptosis in HSCs." -target gene hsa-mir-1273g Liver Cirrhosis 27423040 "Overexpression of miR-1273g-3p could inhibit translation of PTEN, increase the expression of α-SMA, Col1A1, and reduce apoptosis in HSCs." -target gene hsa-mir-696 "Diabetes Mellitus, Type 2" 27432632 "Taken together, our findings demonstrate that miR-696 plays an important role in the development of hepatic gluconeogenesis and insulin resistance through the inhibition of PGC-1α translation in the liver." -target gene hsa-mir-29a Focal Segmental Glomerulosclerosis 27460630 We also demonstrated that miR-29a acts as a positive regulator of Wnt/β-catenin signaling in cultured mesangial cells and functions to protect cell apoptosis and fibrosis. -target gene hsa-mir-203 "Carcinoma, Cervical" 27466497 "Although preliminary, the expression levels of ΔNp63 mRNA and miR-203 seem to be promising for cervical cancer screening." -target gene hsa-mir-23b "Diabetes Mellitus, Type 2" 27467285 Survival of autoreactive T lymphocytes by microRNA-mediated regulation of apoptosis through TRAIL and Fas in type 1 diabetes. -target gene hsa-mir-590 "Diabetes Mellitus, Type 2" 27467285 "Transcriptome analysis revealed reduced expression of TRAIL, TRAIL-R2, FAS and FASLG (members of the extrinsic apoptosis pathway) in patient-derived compared with healthy donor-derived T cells. This was mirrored by increased expression of microRNAs predicted to regulate these particular genes, namely miR-98, miR-23b and miR-590-5p." -target gene hsa-mir-98 "Diabetes Mellitus, Type 2" 27467285 "Transcriptome analysis revealed reduced expression of TRAIL, TRAIL-R2, FAS and FASLG (members of the extrinsic apoptosis pathway) in patient-derived compared with healthy donor-derived T cells. This was mirrored by increased expression of microRNAs predicted to regulate these particular genes, namely miR-98, miR-23b and miR-590-5p." -target gene hsa-mir-124 Breast Neoplasms 27468577 Decreased miR-124-3p Expression Prompted Breast Cancer Cell Progression Mainly by Targeting Beclin-1. -target gene hsa-mir-216b "Carcinoma, Hepatocellular" 27474751 Regulation of UGT2B Expression and Activity by miR-216b-5p in Liver Cancer Cell Lines. -target gene hsa-mir-21 Choriocarcinoma 27475963 "We find various mechanisms of PTEN protein loss in the different tumour cell populations, including allelic PTEN deletions, gross chromosomal 10 aberrations and altered miR-21 expression." -target gene hsa-mir-214 "Carcinoma, Lung" 27494742 miR-214 inhibits lung cancer progression by targeting CPD. -target gene hsa-mir-34a Gastric Neoplasms 27497057 "Our NVs-mediated miR-34a delivery system specifically increased endogenous target miR levels, thereby attenuating proliferation and migration of gastric cancer cells by repressing the expression of CD44 with decreased levels of Bcl-2, Oct 3/4 and Nanog genes." -target gene hsa-mir-128 Glioblastoma 27507538 We demonstrated that miR-31 and miR-128 can bind to the 3'UTR of PVRL4 and decrease PVRL4 levels while anti-miR-31/128 increase PVRL4 levels suggesting that PVRL4 is miRNA targeted. -target gene hsa-mir-6734 "Carcinoma, Colon" 27509128 "Collectively, our results demonstrated that miR-6734 inhibits the growth of colon cancer cells by up-regulating p21 gene expression and subsequent induction of cell cycle arrest and apoptosis, suggesting its role as an important endogenous regulator of cancer cell proliferation and survival." -target gene hsa-mir-199a Osteoarthritis 27515563 Transfection of OA chondrocytes with anti-miR-199a-3p significantly enhanced COX-2 expression and PGE2 production (P < 0.001). -target gene hsa-mir-9 "Carcinoma, Breast" 27520371 CYP4Z1 3'UTR was the potential target of miR-9. CYP4Z1 3'UTR could inhibit the migration and EMT of breast cancer cells via acting as a ceRNA for E-cadherin. -target gene hsa-mir-106b Alzheimer Disease 27520374 miR-106b inhibits A¦Â1-42-induced tau phosphorylation at Tyr18 by targeting Fyn. -target gene hsa-mir-216b "Carcinoma, Hepatocellular" 27524242 this study firstly revealed that there is a HIF-2¦Á-MALAT1-miR-216b axis regulating MDR of HCC cells via modulating autophagy. -target gene hsa-mir-125a Retinal Degeneration 27527066 "Possibly more than 30 miRNAs interact with Rac1 in retina, targeting both UTRs and coding regions." -target gene hsa-mir-142 Retinal Degeneration 27527066 "Possibly more than 30 miRNAs interact with Rac1 in retina, targeting both UTRs and coding regions." -target gene hsa-mir-96 Retinal Degeneration 27527066 "Validation of miRNA-target mRNA interactions for miR-1, miR-96/182 and miR-96 targeting Ctbp2, Rac1 and Slc6a9, respectively, was demonstrated in vitro." -target gene hsa-mir-155 "Leukemia, Myeloid, Acute" 27530922 "our evidence show that IRF3 overexpression in AML promotes cell growth and survival, and miR-155 is involved, indicating that IRF3 may be a potential new biomarker and therapeutic target for AML." -target gene hsa-mir-137 Multiple Myeloma 27531781 The miR137-MITF is an important index in judging the prognosis of multiple myeloma. -target gene hsa-mir-144 "Carcinoma, Hepatocellular" 27536132 "MiR-144 suppresses cell proliferation, migration, and invasion in hepatocellular carcinoma by targeting SMAD4." -target gene hsa-mir-23a "Carcinoma, Ovarian" 27537390 miR-23a promotes IKK¦Á expression but suppresses ST7L expression to contribute to the malignancy of epithelial ovarian cancer cells. -target gene hsa-mir-1283 Vascular Injuries 27537404 miRNA-1283 Regulates the PERK/ATF4 Pathway in Vascular Injury by Targeting ATF4. -target gene hsa-mir-22 Coronary Artery Disease 27537567 miR-22 contributes to the pathogenesis of patients with coronary artery disease by targeting MCP-1: An observational study. -target gene hsa-mir-24 "Carcinoma, Nasopharyngeal" 27538493 Exosomal miR-24-3p impedes T-cell function by targeting FGF11 and serves as a potential prognostic biomarker for nasopharyngeal carcinoma. -target gene hsa-mir-98 Alzheimer Disease 27541017 miR-98-5p Acts as a Target for Alzheimer's Disease by Regulating A¦Â Production Through Modulating SNX6 Expression. -target gene hsa-mir-146a Juvenile Rheumatoid Arthritis 27541693 MiR-146a modulates macrophage polarization in systemic juvenile idiopathic arthritis by targeting INHBA. -target gene hsa-mir-200a "Carcinoma, Hepatocellular" 27542259 Elevated CXCL1 increases hepatocellular carcinoma aggressiveness and is inhibited by miRNA-200a. -target gene hsa-mir-203 "Carcinoma, Gastric" 27542403 MiR-203 inhibits tumor invasion and metastasis in gastric cancer by ATM. -target gene hsa-mir-154 "Cardiomyopathy, Ischemic" 27542661 MiR-154 directly suppresses DKK2 to activate Wnt signaling pathway and enhance activation of cardiac fibroblasts. -target gene hsa-mir-384 "Carcinoma, Hepatocellular" 27542674 MiR-384 regulated IRS1 expression and suppressed cell proliferation of human hepatocellular carcinoma. -target gene hsa-mir-100 IgA Nephropathy 27542871 MiR-100-3p and miR-877-3p regulate overproduction of IL-8 and IL-1¦Â in mesangial cells activated by secretory IgA from IgA nephropathy patients. -target gene hsa-mir-877 IgA Nephropathy 27542871 MiR-100-3p and miR-877-3p regulate overproduction of IL-8 and IL-1¦Â in mesangial cells activated by secretory IgA from IgA nephropathy patients. -target gene hsa-mir-29a Glioma 27543358 Long non-coding RNA H19 regulates glioma angiogenesis and the biological behavior of glioma-associated endothelial cells by inhibiting microRNA-29a. -target gene hsa-mir-187 "Carcinoma, Hepatocellular" 27544906 miR-187-3p inhibits the metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting S100A4. -target gene hsa-mir-613 Alzheimer Disease 27545218 MicroRNA-613 regulates the expression of brain-derived neurotrophic factor in Alzheimer's disease. -target gene hsa-mir-21 Cardiovascular Diseases [unspecific] 27545313 Viral Vector-Based Targeting of miR-21 in Cardiac Nonmyocyte Cells Reduces Pathologic Remodeling of the Heart. -target gene hsa-mir-200b Glioma 27545608 MicroRNA-200b-3p suppresses epithelial-mesenchymal transition and inhibits tumor growth of glioma through down-regulation of ERK5. -target gene hsa-mir-331 "Carcinoma, Cervical" 27548144 MicroRNA-331-3p Suppresses Cervical Cancer Cell Proliferation and E6/E7 Expression by Targeting NRP2. -target gene hsa-mir-29a "Carcinoma, Colon" 27548517 MiR-29a Regulates Radiosensitivity in Human Intestinal Cells by Targeting PTEN Gene. -target gene hsa-mir-297 "Adenocarcinoma, Lung" 27554041 miR-297 acts as an oncogene by targeting GPC5 in lung adenocarcinoma. -target gene hsa-mir-33b "Carcinoma, Lung" 27559850 DNA damage responsive miR-33b-3p promoted lung cancer cells survival and cisplatin resistance by targeting p21WAF1/CIP1. -target gene hsa-mir-138 "Carcinoma, Prostate" 27562865 MiR-26a and miR-138 block the G1/S transition by targeting the cell cycle regulating network in prostate cancer cells. -target gene hsa-mir-26a "Carcinoma, Prostate" 27562865 MiR-26a and miR-138 block the G1/S transition by targeting the cell cycle regulating network in prostate cancer cells. -target gene hsa-mir-106a "Cardiomyopathy, Hypertrophic" 27565029 miR-106a promotes cardiac hypertrophy by targeting mitofusin 2. -target gene hsa-mir-124 "Carcinoma, Cervical" 27571703 "MicroRNA-124 inhibits proliferation, invasion, migration and epithelial-mesenchymal transition of cervical carcinoma cells by targeting astrocyte-elevated gene-1." -target gene hsa-mir-127 "Carcinoma, Ovarian" 27571744 MicroRNA-127-3p acts as a tumor suppressor in epithelial ovarian cancer by regulating the BAG5 gene. -target gene hsa-mir-451 "Carcinoma, Bladder" 27571748 miR-451 suppresses bladder cancer cell migration and invasion via directly targeting c-Myc. -target gene hsa-mir-21 "Carcinoma, Hepatocellular" 27571873 HBx-induced miR-21 suppresses cell apoptosis in hepatocellular carcinoma by targeting interleukin-12. -target gene hsa-mir-588 "Squamous Cell Carcinoma, Lung" 27571908 MicroRNA-588 suppresses tumor cell migration and invasion by targeting GRN in lung squamous cell carcinoma. -target gene hsa-mir-145 Colorectal Carcinoma 27572146 miR-145 suppresses colorectal cancer cell migration and invasion by targeting an ETS-related gene. -target gene hsa-mir-181d "Squamous Cell Carcinoma, Esophageal" 27572270 MicroRNA-181d is a tumor suppressor in human esophageal squamous cell carcinoma inversely regulating Derlin-1. -target gene hsa-mir-411 "Carcinoma, Breast" 27572271 miRNA-411 acts as a potential tumor suppressor miRNA via the downregulation of specificity protein 1 in breast cancer. -target gene hsa-mir-19b "Carcinoma, Gastric" 27572553 MicroRNA-19b inhibits proliferation of gastric cancer cells by targeting B-cell CLL/lymphoma 3. -target gene hsa-mir-15a Human Papilloma Virus Infection 27573302 miR-15a induces cell apoptosis by targeting BCL2L2 and BCL2 in HPV-positive hypopharyngeal squamous cell carcinoma. -target gene hsa-mir-23b "Squamous Cell Carcinoma, Oral" 27573718 The tumor-suppressive microRNA-23b/27b cluster regulates the MET oncogene in oral squamous cell carcinoma. -target gene hsa-mir-27b "Squamous Cell Carcinoma, Oral" 27573718 The tumor-suppressive microRNA-23b/27b cluster regulates the MET oncogene in oral squamous cell carcinoma. -target gene hsa-mir-328 Inflammation 27573788 UPF1 regulates myeloid cell functions and S100A9 expression by the hnRNP E2/miRNA-328 balance. -target gene hsa-mir-195 "Carcinoma, Hepatocellular" 27574422 Aptamer-functionalized peptide H3CR5C as a novel nanovehicle for codelivery of fasudil and miRNA-195 targeting hepatocellular carcinoma. -target gene hsa-mir-491 Hypercholesterolaemia 27575876 Atorvastatin attenuation of ABCB1 expression is mediated by microRNA miR-491-3p in Caco-2 cells. -target gene hsa-mir-30a Colorectal Carcinoma 27576787 MiR-30a-5p Suppresses Tumor Metastasis of Human Colorectal Cancer by Targeting ITGB3. -target gene hsa-mir-216 Bladder Neoplasms 27578985 MiR-126 regulates proliferation and invasion in the bladder cancer BLS cell line by targeting the PIK3R2-mediated PI3K/Akt signaling pathway. -target gene hsa-mir-19a "Squamous Cell Carcinoma, Oral" 27581787 Micronome revealed miR-19a/b as key regulator of SOCS3 during cancer related inflammation of oral squamous cell carcinoma. -target gene hsa-mir-19b "Squamous Cell Carcinoma, Oral" 27581787 Micronome revealed miR-19a/b as key regulator of SOCS3 during cancer related inflammation of oral squamous cell carcinoma. -target gene hsa-mir-421 "Carcinoma, Breast" 27583980 MicroRNA-421 inhibits breast cancer metastasis by targeting metastasis associated 1. -target gene hsa-mir-7 Intervertebral Disc Degeneration 27583982 MicroRNA-7 regulates IL-1¦Â-induced extracellular matrix degeneration by targeting GDF5 in human nucleus pulposus cells. -target gene hsa-mir-98 Osteoarthritis 27590063 MiR-98 promotes chondrocyte apoptosis by decreasing Bcl-2 expression in a rat model of osteoarthritis. -target gene hsa-mir-125b Heart Failure 27592695 MiR-125b regulates SFRP5 expression to promote growth and activation of cardiac fibroblasts. -target gene hsa-mir-31 "Carcinoma, Breast, Triple Negative" 27593563 MiR-31 inhibits migration and invasion by targeting SATB2 in triple negative breast cancer. -target gene hsa-mir-27a Prostate Neoplasms 27594411 Androgen-induced miR-27A acted as a tumor suppressor by targeting MAP2K4 and mediated prostate cancer progression. -target gene hsa-mir-15a "Carcinoma, Breast" 27596816 miR-15a/miR-16 induces mitochondrial dependent apoptosis in breast cancer cells by suppressing oncogene BMI1. -target gene hsa-mir-16 "Carcinoma, Breast" 27596816 miR-15a/miR-16 induces mitochondrial dependent apoptosis in breast cancer cells by suppressing oncogene BMI1. -target gene hsa-mir-141 "Carcinoma, Breast" 27596953 p16INK4A induces senescence and inhibits EMT through microRNA-141/microRNA-146b-5p-dependent repression of AUF1. -target gene hsa-mir-146b "Carcinoma, Breast" 27596953 p16INK4A induces senescence and inhibits EMT through microRNA-141/microRNA-146b-5p-dependent repression of AUF1. -target gene hsa-mir-15a Myeloma 27596960 "MiR-15a/16 regulates the growth of myeloma cells, angiogenesis and antitumor immunity by inhibiting Bcl-2, VEGF-A and IL-17 expression in multiple myeloma." -target gene hsa-mir-16 Myeloma 27596960 "MiR-15a/16 regulates the growth of myeloma cells, angiogenesis and antitumor immunity by inhibiting Bcl-2, VEGF-A and IL-17 expression in multiple myeloma." -target gene hsa-mir-199a "Carcinoma, Hepatocellular" 27599545 Anti-invasion and anti-migration effects of miR-199a-3p in hepatocellular carcinoma are due in part to targeting CD151. -target gene hsa-mir-3666 "Carcinoma, Lung, Non-Small-Cell" 27599551 MicroRNA-3666-induced suppression of SIRT7 inhibits the growth of non-small cell lung cancer cells. -target gene hsa-mir-181a Osteosarcoma 27600004 miR-181a promotes the proliferation and metastasis of osteosarcoma cells by targeting RASSF1A. -target gene hsa-mir-150 "Leukemia, Myeloid, Acute" 27601730 AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB. -target gene hsa-mir-155 "Leukemia, Myeloid, Acute" 27601730 AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB. -target gene hsa-mir-23a "Carcinoma, Endometrioid Endometrial" 27601936 MicroRNA-23a regulates epithelial-to-mesenchymal transition in endometrial endometrioid adenocarcinoma by targeting SMAD3. -target gene hsa-mir-19b Breast Neoplasms 27602768 MiR-19b suppresses PTPRG to promote breast tumorigenesis. -target gene hsa-mir-9 Knee Osteoarthritis 27603333 MicroRNA-9 regulates the development of knee osteoarthritis through the NF-kappaB1 pathway in chondrocytes. -target gene hsa-mir-139 Leukemia 27605510 MicroRNA-139-5p regulates proliferation of hematopoietic progenitors and is repressed during BCR-ABL-mediated leukemogenesis. -target gene hsa-mir-15a Endometriosis 27608888 miRNA-15a-5p regulates VEGFA in endometrial mesenchymal stem cells and contributes to the pathogenesis of endometriosis. -target gene hsa-mir-141 Glioma 27608897 MiR-200c and miR-141 inhibit ZEB1 synergistically and suppress glioma cell growth and migration. -target gene hsa-mir-200c Glioma 27608897 MiR-200c and miR-141 inhibit ZEB1 synergistically and suppress glioma cell growth and migration. -target gene hsa-mir-135a "Carcinoma, Hepatocellular" 27609066 "HBXIP is able to depress the gluconeogenesis through suppressing PCK1 to promote hepatocarcinogenesis, involving miR-135a/FOXO1 axis and PI3K/Akt/p-FOXO1 pathway" -target gene hsa-mir-148a Ischemia-Reperfusion Injury 27609576 The miR-148a alleviates hepatic ischemia/reperfusion injury in mice via targeting CaMKII¦Á. -target gene hsa-mir-34a Influenza 27610823 MicroRNA 34a contributes to virus-mediated apoptosis through binding to its target gene Bax in influenza A virus infection. -target gene hsa-mir-126 Neoplasms [unspecific] 27611944 MicroRNA-126 inhibits tumor proliferation and angiogenesis of hepatocellular carcinoma by down-regulating EGFL7 expression. -target gene hsa-mir-21 Gastric Neoplasms 27611950 MicroRNA-21 promotes TGF-¦Â1-induced epithelial-mesenchymal transition in gastric cancer through up-regulating PTEN expression. -target gene hsa-mir-34a "Carcinoma, Oral" 27612478 "miR5423p and miR34a targets the CD44v6-Nanog-PTEN axis, thus playing a vital role in regulating the CSC properties" -target gene hsa-mir-542 "Carcinoma, Oral" 27612478 "miR5423p and miR34a targets the CD44v6-Nanog-PTEN axis, thus playing a vital role in regulating the CSC properties" -target gene hsa-mir-451 Colorectal Carcinoma 27612504 Expression pattern of miR-451 and its target MIF (macrophage migration inhibitory factor) in colorectal cancer. -target gene hsa-mir-1271 "Diabetes Mellitus, Type 2" 27613089 MiR-1271 upregulated by saturated fatty acid palmitate provokes impaired insulin signaling by repressing INSR and IRS-1 expression in HepG2 cells. -target gene hsa-mir-26a Neoplasms [unspecific] 27613140 MiR-26a inhibits proliferation and migration of HaCaT keratinocytes through regulating PTEN expression. -target gene hsa-mir-223 "Carcinoma, Breast, Triple Negative" 27618431 MicroRNA-223 Increases the Sensitivity of Triple-Negative Breast Cancer Stem Cells to TRAIL-Induced Apoptosis by Targeting HAX-1. -target gene hsa-mir-106b "Squamous Cell Carcinoma, Esophageal" 27619676 MiR-106b promotes migration and invasion through enhancing EMT via downregulation of Smad 7 in Kazakh's esophageal squamous cell carcinoma. -target gene hsa-mir-214 "Squamous Cell Carcinoma, Esophageal" 27619677 miR-214 inhibits invasion and migration via downregulating GALNT7 in esophageal squamous cell cancer. -target gene hsa-mir-346 Preeclampsia 27619846 miR-346 and miR-582-3p-regulated EG-VEGF expression and trophoblast invasion via matrix metalloproteinases 2 and 9. -target gene hsa-mir-582 Preeclampsia 27619846 miR-346 and miR-582-3p-regulated EG-VEGF expression and trophoblast invasion via matrix metalloproteinases 2 and 9. -target gene hsa-let-7 "Carcinoma, Bladder" 27620744 A let-7 microRNA binding site polymorphism in the KRAS 3'UTR is associated with increased risk and reduced survival for gallbladder cancer in North Indian population. -target gene hsa-mir-126 "Carcinoma, Gastric" 27622325 MicroRNA-126 increases chemosensitivity in drug-resistant gastric cancer cells by targeting EZH2. -target gene hsa-mir-224 "Carcinoma, Cervical" 27626930 Over-Expressed miR-224 Promotes the Progression of Cervical Cancer via Targeting RASSF8. -target gene hsa-mir-4262 "Carcinoma, Breast" 27629257 miR-4262 Promotes Proliferation and Invasion of Human Breast Cancer Cells Through Directly Targeting KLF6 and KLF15. -target gene hsa-mir-22 Parkinson Disease 27631550 Neuroprotective Role of MicroRNA-22 in a 6-Hydroxydopamine-Induced Cell Model of Parkinson's Disease via Regulation of Its Target Gene TRPM7. -target gene hsa-mir-7 "Carcinoma, Thyroid, Papillary" 27633373 "MicroRNA-7 inhibits proliferation, migration and invasion of thyroid papillary cancer cells via targeting CKS2." -target gene hsa-mir-330 "Carcinoma, Colon" 27633518 MicroRNA-330-5p negatively regulates ITGA5 expression in human colorectal cancer. -target gene hsa-mir-218 "Squamous Cell Carcinoma, Lung" 27633630 Regulation of TPD52 by antitumor microRNA-218 suppresses cancer cell migration and invasion in lung squamous cell carcinoma. -target gene hsa-mir-30c Heart Failure 27633839 MiRNA-30e mediated cardioprotection of ACE2 in rats with Doxorubicin-induced heart failure through inhibiting cardiomyocytes autophagy. -target gene hsa-mir-30e Heart Failure 27633839 MiRNA-30e mediated cardioprotection of ACE2 in rats with Doxorubicin-induced heart failure through inhibiting cardiomyocytes autophagy. -target gene hsa-let-7g Glioblastoma 27634309 Let-7g-5p inhibits epithelial-mesenchymal transition consistent with reduction of glioma stem cell phenotypes by targeting VSIG4 in glioblastoma. -target gene hsa-mir-187 "Carcinoma, Lung" 27634346 MicroRNA?187 is an independent prognostic factor in lung cancer and promotes lung cancer cell invasion via targeting of PTRF. -target gene hsa-mir-377 "Carcinoma, Pancreatic" 27638830 MiR-377 inhibits the proliferation of pancreatic cancer by targeting Pim-3. -target gene hsa-mir-17 Pulmonary Hypertension 27640178 Upregulated miR-17 Regulates Hypoxia-Mediated Human Pulmonary Artery Smooth Muscle Cell Proliferation and Apoptosis by Targeting Mitofusin 2. -target gene hsa-mir-182 Lung Neoplasms 27641336 The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis. -target gene hsa-mir-181b Psoriasis 27641447 MicroRNA-181b negatively regulates the proliferation of human epidermal keratinocytes in psoriasis through targeting TLR4. -target gene hsa-mir-361 "Carcinoma, Hepatocellular" 27641667 miR-361-5p inhibits hepatocellular carcinoma cell proliferation and invasion by targeting VEGFA. -target gene hsa-mir-1304 "Carcinoma, Lung, Non-Small-Cell" 27641735 MicroRNA-1304 suppresses human non-small cell lung cancer cell growth in vitro by targeting heme oxygenase-1. -target gene hsa-mir-218 "Carcinoma, Gastric" 27642088 "miR-218 Inhibits Proliferation, Migration, and EMT of Gastric Cancer Cells by Targeting WASF3." -target gene hsa-mir-135b "Carcinoma, Lung, Non-Small-Cell" 27643554 miR-135b reverses chemoresistance of non-small cell lung cancer cells by downregulation of FZD1. -target gene hsa-mir-185 "Carcinoma, Hepatocellular" 27643556 our findings enlarged our knowledge about the roles of PLAC8 in HCC progression and miR-185-5p/PLAC8/¦Â-catenin axis might be a novel pathway for HCC treatment -target gene hsa-mir-141 "Carcinoma, Esophageal" 27644195 Involvement of microRNA-141-3p in 5-fluorouracil and oxaliplatin chemo-resistance in esophageal cancer cells via regulation of PTEN. -target gene hsa-mir-124 Osteosarcoma 27644254 The tumor suppressor miR-124 inhibits cell proliferation and invasion by targeting B7-H3 in osteosarcoma. -target gene hsa-mir-21 Leukemia 27644439 Bmi-1 regulates stem cell-like properties of gastric cancer cells via modulating miRNAs. -target gene hsa-mir-127 "Squamous Cell Carcinoma, Esophageal" 27645894 MicroRNA-127 is a tumor suppressor in human esophageal squamous cell carcinoma through the regulation of oncogene FMNL3. -target gene hsa-mir-181b Colorectal Carcinoma 27647131 miR-181b functions as an oncomiR in colorectal cancer by targeting PDCD4. -target gene hsa-mir-494 "Carcinoma, Colon" 27648301 Targeting the metabolic pathway of human colon cancer overcomes resistance to TRAIL-induced apoptosis. -target gene hsa-mir-138 Pulmonary Hypertension 27648837 "MicroRNA-138 and MicroRNA-25 Down-regulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype." -target gene hsa-mir-25 Pulmonary Hypertension 27648837 "MicroRNA-138 and MicroRNA-25 Down-regulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype." -target gene hsa-mir-29 Osteosarcoma 27649654 Targeting miR-29 induces apoptosis of osteosarcoma MG-63 cells via regulation of TGF-¦Â1/PUMA signal. -target gene hsa-mir-24 "Carcinoma, Hepatocellular" 27650047 MiR-24-3p enhances cell growth in hepatocellular carcinoma by targeting metallothionein 1M. -target gene hsa-mir-185 "Carcinoma, Breast" 27651238 RKIP suppresses the proliferation and metastasis of breast cancer cell lines through up-regulation of miR-185 targeting HMGA2. -target gene hsa-mir-30a "Carcinoma, Nasopharyngeal" 27656832 IGF-I Induces Epithelial-to-Mesenchymal Transition via the IGF-IR-Src-MicroRNA-30a-E-Cadherin Pathway in Nasopharyngeal Carcinoma Cells. -target gene hsa-mir-124 Melanoma 27657824 Upregulation of miR-124 by physcion 8-O-¦Â-glucopyranoside inhibits proliferation and invasion of malignant melanoma cells via repressing RLIP76. -target gene hsa-mir-92b "Squamous Cell Carcinoma, Esophageal" 27659550 "RAB23, regulated by miR-92b, promotes the progression of esophageal squamous cell carcinoma." -target gene hsa-mir-33b Osteosarcoma 27662380 MicroRNA-33b Inhibits the Proliferation and Migration of Osteosarcoma Cells via Targeting Hypoxia-Inducible Factor-1¦Á. -target gene hsa-mir-199a Liver Cirrhosis 27662798 Fibrogenic Signaling Is Suppressed in Hepatic Stellate Cells through Targeting of Connective Tissue Growth Factor (CCN2) by Cellular or Exosomal MicroRNA-199a-5p. -target gene hsa-mir-21 Cardiovascular Diseases [unspecific] 27663503 "DDAH1 3'-UTR as a target for miR-21, and endogenous miR-21 showed increased inhibitory effect on DDAH1-V3 transcript" -target gene hsa-mir-215 "Carcinoma, Colon" 27663660 "MicroRNA-215 suppresses cell proliferation, migration and invasion of colon cancer by repressing Yin-Yang 1." -target gene hsa-mir-224 "Carcinoma, Ovarian" 27663866 Upregulated microRNA-224 promotes ovarian cancer cell proliferation by targeting KLLN. -target gene hsa-mir-463 Diabetes Mellitus 27664094 MicroRNA-463-3p/ABCG4: A new axis in glucose-stimulated insulin secretion. -target gene hsa-mir-181a "Carcinoma, Renal Cell" 27664584 microRNAs target SRSF7 splicing factor to modulate the expression of osteopontin splice variants in renal cancer cells. -target gene hsa-mir-30a "Carcinoma, Renal Cell" 27664584 microRNAs target SRSF7 splicing factor to modulate the expression of osteopontin splice variants in renal cancer cells. -target gene hsa-mir-370 Hepatitis B Virus Infection 27664977 miR-370 suppresses HBV gene expression and replication by targeting nuclear factor IA. -target gene hsa-mir-138 "Carcinoma, Lung, Non-Small-Cell" 27665963 MicroRNA-138 inhibits migration and invasion of non-small cell lung cancer cells by targeting LIMK1. -target gene hsa-mir-200c "Carcinoma, Lung" 27666124 miR-200c regulates crizotinib-resistant ALK-positive lung cancer cells by reversing epithelial-mesenchymal transition via targeting ZEB1. -target gene hsa-let-7a "Squamous Cell Carcinoma, Lung" 27666488 MicroRNAs modulate the expression of the SOX18 transcript in lung squamous cell carcinoma. -target gene hsa-mir-24 "Squamous Cell Carcinoma, Lung" 27666488 MicroRNAs modulate the expression of the SOX18 transcript in lung squamous cell carcinoma. -target gene hsa-mir-210 "Carcinoma, Hepatocellular" 27666683 MicroRNA-210 promotes cancer angiogenesis by targeting fibroblast growth factor receptor-like?1 in hepatocellular carcinoma. -target gene hsa-mir-19a Diabetes Mellitus 27666763 "MicroRNA-19a-3p enhances the proliferation and insulin secretion, while it inhibits the apoptosis of pancreatic ¦Â?cells via the inhibition of SOCS3." -target gene hsa-mir-101 "Leukemia, Lymphoblastic, Acute, T-Cell" 27666896 MicroRNA-101 regulates T-cell acute lymphoblastic leukemia progression and chemotherapeutic sensitivity by targeting Notch1. -target gene hsa-mir-372 "Carcinoma, Prostate" 27673408 microRNA-372 Suppresses Migration and Invasion by Targeting p65 in Human Prostate Cancer Cells. -target gene hsa-mir-122 Chronic Hepatitis C 27677491 microRNA-122 target sites in the hepatitis C virus RNA NS5B coding region and 3' untranslated region: function in replication and influence of RNA secondary structure. -target gene hsa-mir-16 "Carcinoma, Gastric" 27683052 Direct targeting of HGF by miR-16 regulates proliferation and migration in gastric cancer. -target gene hsa-mir-192 Osteosarcoma 27683056 Upregulation of miR-192 inhibits cell growth and invasion and induces cell apoptosis by targeting TCF7 in human osteosarcoma. -target gene hsa-mir-490 "Carcinoma, Lung" 27683057 MicroRNA-490 regulates lung cancer metastasis by targeting poly r(C)-binding protein 1. -target gene hsa-mir-204 "Carcinoma, Prostate" 27686228 The UCA1/miR-204/Sirt1 axis modulates docetaxel sensitivity of prostate cancer cells. -target gene hsa-mir-451 "Carcinoma, Lung" 27686452 MicroRNA-451 sensitizes lung cancer cells to cisplatin through regulation of Mcl-1. -target gene hsa-mir-122 "Carcinoma, Hepatocellular" 27687586 WNT1 Gene from WNT Signaling Pathway Is a Direct Target of miR-122 in Hepatocellular Carcinoma. -target gene hsa-mir-483 Cervical Neoplasms 27693430 miR-483 is a self-regulating microRNA and can activate its own expression via USF1 in HeLa cells. -target gene hsa-mir-214 "Carcinoma, Breast" 27693451 "Crosstalk between the vitamin D receptor (VDR) and miR-214 in regulating SuFu, a hedgehog pathway inhibitor in breast cancer cells." -target gene hsa-mir-939 "Carcinoma, Breast" 27693459 Breast cancer-secreted miR-939 downregulates VE-cadherin and destroys the barrier function of endothelial monolayers. -target gene hsa-mir-1207 "Carcinoma, Prostate" 27693493 miR-1207-3p regulates the androgen receptor in prostate cancer via FNDC1/fibronectin. -target gene hsa-mir-125a "Carcinoma, Breast" 27693788 Enforced expression of hsa-miR-125a-3p in breast cancer cells potentiates docetaxel sensitivity via modulation of BRCA1 signaling. -target gene hsa-mir-9 "Carcinoma, Laryngeal" 27694005 Enhanced miR-9 promotes laryngocarcinoma cell survival via down-regulating PTEN. -target gene hsa-mir-34a Cardiovascular Diseases [unspecific] 27694688 it could be considered as a circulating biomarker for anthracycline-induced cardiac damage -target gene hsa-mir-218 "Carcinoma, Gastric" 27696291 "MicroRNA-218 inhibits the proliferation, migration, and invasion and promotes apoptosis of gastric cancer cells by targeting LASP1." -target gene hsa-mir-935 "Carcinoma, Hepatocellular" 27697092 miR-935 Promotes Liver Cancer Cell Proliferation and Migration by Targeting SOX7. -target gene hsa-mir-509 "Carcinoma, Gastric" 27697095 MicroRNA-509-3p Inhibits Cancer Cell Proliferation and Migration via Upregulation of XIAP in Gastric Cancer Cells. -target gene hsa-mir-1298 Lung Neoplasms 27698189 miR-1298 Inhibits Mutant KRAS-Driven Tumor Growth by Repressing FAK and LAMB3. -target gene hsa-mir-186 Melanoma 27698793 miR-186 suppressed CYLD expression and promoted cell proliferation in human melanoma. -target gene hsa-mir-182 "Squamous Cell Carcinoma, Tongue" 27698823 miRNA-335 and miRNA-182 affect the occurrence of tongue squamous cell carcinoma by targeting survivin. -target gene hsa-mir-101 "Carcinoma, Hepatocellular" 27702662 Upregulation of SNHG6 regulates ZEB1 expression by competitively binding miR-101-3p and interacting with UPF1 in hepatocellular carcinoma. -target gene hsa-mir-34c "Carcinoma, Hepatocellular" 27704267 MicroRNA-34c-3p promotes cell proliferation and invasion in hepatocellular carcinoma by regulation of NCKAP1 expression. -target gene hsa-mir-27b "Carcinoma, Hepatocellular" 27704356 MicroRNA-27b exerts an oncogenic function by targeting Fbxw7 in human hepatocellular carcinoma. -target gene hsa-mir-491 Osteosarcoma 27704627 Up-regulation of microRNA-491-5p suppresses cell proliferation and promotes apoptosis by targeting FOXP4 in human osteosarcoma. -target gene hsa-mir-15a Breast Neoplasms 27713175 Fatty acid synthase is a primary target of MiR-15a and MiR-16-1 in breast cancer. -target gene hsa-mir-16 Breast Neoplasms 27713175 Fatty acid synthase is a primary target of MiR-15a and MiR-16-1 in breast cancer. -target gene hsa-mir-186 "Carcinoma, Lung, Non-Small-Cell" 27714074 miR-186 regulates chemo-sensitivity to paclitaxel via targeting MAPT in non-small cell lung cancer (NSCLC). -target gene hsa-mir-296 "Carcinoma, Hepatocellular" 27714806 miR-296 inhibits proliferation and induces apoptosis by targeting FGFR1 in human hepatocellular carcinoma. -target gene hsa-mir-144 "Carcinoma, Renal Cell" 27717821 miR-144-3p serves as a tumor suppressor for renal cell carcinoma and inhibits its invasion and metastasis by targeting MAP3K8. -target gene hsa-mir-216b "Carcinoma, Breast" 27720715 miR-216b suppresses breast cancer growth and metastasis by targeting SDCBP. -target gene hsa-mir-320 Osteosarcoma 27721258 Inhibitory roles of miR-320 in osteosarcoma via regulating E2F1. -target gene hsa-mir-326 Osteosarcoma 27723574 MiR-326 is a diagnostic biomarker and regulates cell survival and apoptosis by targeting Bcl-2 in osteosarcoma. -target gene hsa-mir-221 Pancreatic Neoplasms 27726102 MiRNA-221-3p desensitizes pancreatic cancer cells to 5-fluorouracil by targeting RB1. -target gene hsa-mir-126 Rheumatoid Arthritis 27729613 MicroRNA-126 affects rheumatoid arthritis synovial fibroblast proliferation and apoptosis by targeting PIK3R2 and regulating PI3K-AKT signal pathway. -target gene hsa-mir-133a "Carcinoma, Laryngeal" 27730543 "MicroRNA-133a suppresses the proliferation, migration, and invasion of laryngeal carcinoma cells by targeting CD47." -target gene hsa-mir-145 Atherosclerosis 27731400 miRNA-145 inhibits VSMC proliferation by targeting CD40. -target gene hsa-mir-139 Epilepsy 27731509 MicroRNA-139-5p negatively regulates NR2A-containing NMDA receptor in the rat pilocarpine model and patients with temporal lobe epilepsy. -target gene hsa-mir-203 "Adenocarcinoma, Lung" 27733346 Direct interaction between miR-203 and ZEB2 suppresses epithelial-mesenchymal transition signaling and reduces lung adenocarcinoma chemoresistance. -target gene hsa-mir-494 "Carcinoma, Gastric" 27735036 miR-494 inhibits invasion and proliferation of gastric cancer by targeting IGF-1R. -target gene hsa-mir-124 "Carcinoma, Lung" 27735038 MicroRNA-124 suppresses Slug-mediated lung cancer metastasis. -target gene hsa-mir-132 "Carcinoma, Lung, Non-Small-Cell" 27735039 "MicroRNA-132 inhibits migration, invasion and epithelial-mesenchymal transition by regulating TGF¦Â1/Smad2 in human non-small cell lung cancer." -target gene hsa-mir-21 Wound Healing 27735045 microRNA-21 mediates the TGF-¦Â1-induced migration of keratinocytes via targeting PTEN. -target gene hsa-mir-590 "Carcinoma, Colon" 27735951 MiR-590-5p inhibits colorectal cancer angiogenesis and metastasis by regulating nuclear factor 90/vascular endothelial growth factor A axis. -target gene hsa-mir-105 Glioma 27736002 MicroRNA-105 targets SOX9 and inhibits human glioma cell progression. -target gene hsa-mir-149 "Diabetes Mellitus, Type 1" 27737950 "MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic ¦Â-Cells." -target gene hsa-mir-23a "Diabetes Mellitus, Type 1" 27737950 "MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic ¦Â-Cells." -target gene hsa-mir-23b "Diabetes Mellitus, Type 1" 27737950 "MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic ¦Â-Cells." -target gene hsa-mir-183 "Leukemia, Myeloid, Acute, Pediatric" 27738758 MicroRNA-183 promotes cell proliferation via regulating programmed cell death 6 in pediatric acute myeloid leukemia. -target gene hsa-mir-585 "Carcinoma, Lung, Non-Small-Cell" 27743168 MicroRNA-585 acts as a tumor suppressor in non-small-cell lung cancer by targeting hSMG-1. -target gene hsa-mir-551b "Carcinoma, Ovarian" 27743201 "Downregulation of Foxo3 and TRIM31 by miR-551b in side population promotes cell proliferation, invasion, and drug resistance of ovarian cancer." -target gene hsa-mir-124 Osteosarcoma 27743351 MicroRNA-124 upregulation inhibits proliferation and invasion of osteosarcoma cells by targeting sphingosine kinase 1. -target gene hsa-mir-25 "Carcinoma, Cervical" 27743413 miR-25-3p reverses epithelial-mesenchymal transition via targeting Sema4C in cisplatin-resistance cervical cancer cells. -target gene hsa-mir-96 "Carcinoma, Prostate" 27746161 Epidermal growth factor receptor signaling promotes metastatic prostate cancer through microRNA-96-mediated downregulation of the tumor suppressor ETV6. -target gene hsa-mir-1297 "Carcinoma, Prostate" 27746178 MicroRNA-1297 inhibits prostate cancer cell proliferation and invasion by targeting the AEG-1/Wnt signaling pathway. -target gene hsa-mir-155 Idiopathic Pulmonary Fibrosis 27746237 The role of microRNA-155/liver X receptor pathway in experimental and idiopathic pulmonary fibrosis. -target gene hsa-mir-16 Recurrent Spontaneous Abortion 27748453 MicroRNA-16 inhibits feto-maternal angiogenesis and causes recurrent spontaneous abortion by targeting vascular endothelial growth factor. -target gene hsa-mir-204 "Carcinoma, Hepatocellular" 27748572 miR-204-5p targeting SIRT1 regulates hepatocellular carcinoma progression. -target gene hsa-mir-16 Glioma 27748823 "MicroRNA-16 inhibits the proliferation, migration and invasion of glioma cells by targeting Sal-like protein?4." -target gene hsa-mir-203 Myeloma 27748826 miR-203 inhibits cell growth and regulates G1/S transition by targeting Bmi-1 in myeloma cells. -target gene hsa-mir-382 "Carcinoma, Prostate" 27748848 MicroRNA-382 inhibits prostate cancer cell proliferation and metastasis through targeting COUP-TFII. -target gene hsa-mir-455 "Carcinoma, Hepatocellular" 27748890 MicroRNA-455 regulates migration and invasion of human hepatocellular carcinoma by targeting Runx2. -target gene hsa-mir-124 "Carcinoma, Breast" 27748910 MicroRNA-124 inhibits cell proliferation and migration by regulating SNAI2 in breast cancer. -target gene hsa-mir-20a "Carcinoma, Hepatocellular" 27748919 MicroRNA-20a-5p targets RUNX3 to regulate proliferation and migration of human hepatocellular cancer cells. -target gene hsa-mir-520a "Carcinoma, Lung, Non-Small-Cell" 27748920 microRNA-520a-3p inhibits proliferation and cancer stem cell phenotype by targeting HOXD8 in non-small cell lung cancer. -target gene hsa-mir-132 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 27751825 MiR-132 plays an oncogenic role in laryngeal squamous cell carcinoma by targeting FOXO1 and activating the PI3K/AKT pathway. -target gene hsa-mir-27b Atherosclerosis 27755984 miRNA-27b modulates endothelial cell angiogenesis by directly targeting Naa15 in atherogenesis. -target gene hsa-mir-10b "Carcinoma, Hepatocellular" 27756250 miR-10b exerts oncogenic activity in human hepatocellular carcinoma cells by targeting expression of CUB and sushi multiple domains 1 (CSMD1). -target gene hsa-mir-302 Neoplasms [unspecific] 27756792 A MicroRNA302-367-Erk1/2-Klf2-S1pr1 Pathway Prevents Tumor Growth via Restricting Angiogenesis and Improving Vascular Stability. -target gene hsa-mir-9 Cardiac Fibrosis 27756824 "MicroRNA-9 inhibits high glucose-induced proliferation, differentiation and collagen accumulation of cardiac fibroblasts by down-regulation of TGFBR2." -target gene hsa-mir-9 "Fatty Liver, Non-Alcoholic" 27756894 Altered microRNA-9 Expression Level is Directly Correlated with Pathogenesis of Nonalcoholic Fatty Liver Disease by Targeting Onecut2 and SIRT1. -target gene hsa-mir-182 Heart Failure 27763637 miR-182 negatively regulated Nogo-C expression and was downregulated during MI -target gene hsa-mir-10b Osteosarcoma 27764757 miR-10b promotes invasion by targeting KLF4 in osteosarcoma cells. -target gene hsa-mir-451 "Leukemia, Myeloid, Acute" 27764807 c-Myc suppresses miR-451?YWTAZ/AKT axis via recruiting HDAC3 in acute myeloid leukemia. -target gene hsa-mir-21 Arteriosclerosis Obliterans 27765464 Cigarette smoking represses expression of cytokine IL-12 and its regulator miR-21-An observational study in patients with coronary artery disease. -target gene hsa-mir-29c Idiopathic Pulmonary Fibrosis 27765762 "MicroRNA-29c regulates apoptosis sensitivity via modulation of the cell-surface death receptor, Fas, in lung fibroblasts." -target gene hsa-mir-33a "Carcinoma, Gallbladder" 27769047 The microRNA miR-33a suppresses IL-6-induced tumor progression by binding Twist in gallbladder cancer. -target gene hsa-mir-16 Chronic Inflammatory Pain 27770129 MicroRNA-16 Alleviates Inflammatory Pain by Targeting Ras-Related Protein 23 (RAB23) and Inhibiting p38 MAPK Activation. -target gene hsa-mir-590 "Carcinoma, Lung, Non-Small-Cell" 27770372 microRNA-590 suppresses the tumorigenesis and invasiveness of non-small cell lung cancer cells by targeting ADAM9. -target gene hsa-let-7i Neoplasms [unspecific] 27770612 Let-7i-Induced Atg4B Suppression Is Essential for Autophagy of Placental Trophoblast in Preeclampsia. -target gene hsa-mir-145 "Squamous Cell Carcinoma, Esophageal" 27771733 MicroRNA-145 Inhibits Cell Migration and Invasion and Regulates Epithelial-Mesenchymal Transition (EMT) by Targeting Connective Tissue Growth Factor (CTGF) in Esophageal Squamous Cell Carcinoma. -target gene hsa-mir-218 "Carcinoma, Colon" 27773352 DCC Confers Susceptibility to Depression-like Behaviors in Humans and Mice and Is Regulated by miR-218. -target gene hsa-mir-107 "Carcinoma, Hepatocellular" 27773820 MiR-107 suppresses proliferation of hepatoma cells through targeting HMGA2 mRNA 3'UTR. -target gene hsa-mir-125b Diabetic Nephropathy 27775793 microRNA-125b contributes to high glucose-induced reactive oxygen species generation and apoptosis in HK-2 renal tubular epithelial cells by targeting angiotensin-converting enzyme 2. -target gene hsa-mir-1 Osteosarcoma 27777493 "miR-1 Inhibits Cell Growth, Migration, and Invasion by Targeting VEGFA in Osteosarcoma Cells." -target gene hsa-mir-375 "Squamous Cell Carcinoma, Esophageal" 27779648 Regulation of MMP13 by antitumor microRNA-375 markedly inhibits cancer cell migration and invasion in esophageal squamous cell carcinoma. -target gene hsa-mir-19a "Carcinoma, Renal Cell, Clear-Cell" 27779660 miR-19a correlates with poor prognosis of clear cell renal cell carcinoma patients via promoting cell proliferation and suppressing PTEN/SMAD4 expression. -target gene hsa-mir-4262 Cutaneous Melanoma 27779691 miR-4262 promotes the proliferation of human cutaneous malignant melanoma cells through KLF6-mediated EGFR inactivation and p21 upregulation. -target gene hsa-mir-574 "Carcinoma, Prostate" 27779701 Downregulation of microRNA?574 in cancer stem cells causes recurrence of prostate cancer via targeting REL. -target gene hsa-mir-300 "Carcinoma, Colon" 27779716 miR-300 promotes proliferation and EMT-mediated colorectal cancer migration and invasion by targeting p53. -target gene hsa-mir-148a "Carcinoma, Thyroid" 27779717 miR-148a inhibits self-renewal of thyroid cancer stem cells via repressing INO80 expression. -target gene hsa-mir-218 Colorectal Carcinoma 27779719 Downregulation of YEATS4 by miR-218 sensitizes colorectal cancer cells to L-OHP-induced cell apoptosis by inhibiting cytoprotective autophagy. -target gene hsa-mir-24 "Carcinoma, Hepatocellular" 27780140 MicroRNA-24 increases hepatocellular carcinoma cell metastasis and invasion by targeting p53: miR-24 targeted p53. -target gene hsa-mir-34b Spinal Cord Injuries 27780189 Changes in the Expression of miR-34a and its Target Genes Following Spinal Cord Injury In Rats. -target gene hsa-mir-34c Spinal Cord Injuries 27780189 Changes in the Expression of miR-34a and its Target Genes Following Spinal Cord Injury In Rats. -target gene hsa-mir-203a "Carcinoma, Hepatocellular" 27780730 miR-203a is involved in HBx-induced inflammation by targeting Rap1a. -target gene hsa-mir-379 Osteosarcoma 27781416 MicroRNA-379 suppresses osteosarcoma progression by targeting PDK1. -target gene hsa-mir-155 "Leukemia, Myeloid, Acute" 27786352 Targeting miR-155 suppresses proliferation and induces apoptosis of HL-60 cells by targeting Slug/PUMA signal. -target gene hsa-mir-101 Glioblastoma 27792996 MicroRNA-101 reverses temozolomide resistance by inhibition of GSK3¦Â in glioblastoma. -target gene hsa-mir-637 Pulmonary Hypertension 27794186 Downregulation of microRNA-637 Increases Risk of Hypoxia-Induced Pulmonary Hypertension by Modulating Expression of Cyclin Dependent Kinase 6 (CDK6) in Pulmonary Smooth Muscle Cells. -target gene hsa-mir-133a Osteosarcoma 27794430 Down-regulation of RBP-J mediated by microRNA-133a suppresses dendritic cells and functions as a potential tumor suppressor in osteosarcoma. -target gene hsa-mir-182 "Carcinoma, Pancreatic" 27797718 MicroRNA-182 promotes pancreatic cancer cell proliferation and migration by targeting ¦Â-TrCP2. -target gene hsa-mir-106b "Carcinoma, Lung" 27797825 "MCM7 and its hosted miR-25, 93 and 106b cluster elicit YAP/TAZ oncogenic activity in lung cancer." -target gene hsa-mir-25 "Carcinoma, Lung" 27797825 "MCM7 and its hosted miR-25, 93 and 106b cluster elicit YAP/TAZ oncogenic activity in lung cancer." -target gene hsa-mir-93 "Carcinoma, Lung" 27797825 "MCM7 and its hosted miR-25, 93 and 106b cluster elicit YAP/TAZ oncogenic activity in lung cancer." -target gene hsa-mir-145 Polycystic Ovarian Syndrome 27799458 MicroRNA-145 Negatively Regulates Cell Proliferation Through Targeting IRS1 in Isolated Ovarian Granulosa Cells From Patients With Polycystic Ovary Syndrome. -target gene hsa-mir-25 Melanoma 27801786 Upregulated MicroRNA-25 Mediates the Migration of Melanoma Cells by Targeting DKK3 through the WNT/¦Â-Catenin Pathway. -target gene hsa-mir-92a Glioma 27801803 miR-92a-3p Exerts Various Effects in Glioma and Glioma Stem-Like Cells Specifically Targeting CDH1/¦Â-Catenin and Notch-1/Akt Signaling Pathways. -target gene hsa-mir-133b "Carcinoma, Ovarian" 27802259 Down-Regulation of MicroRNA-133b Suppresses Apoptosis of Lens Epithelial Cell by Up-Regulating BCL2L2 in Age-Related Cataracts. -target gene hsa-mir-181a Acute Lung Injury 27802900 Downregulation of miR-181a protects mice from LPS-induced acute lung injury by targeting Bcl-2. -target gene hsa-mir-20a Tuberculosis 27803889 microRNA-20a Inhibits Autophagic Process by Targeting ATG7 and ATG16L1 and Favors Mycobacterial Survival in Macrophage Cells. -target gene hsa-mir-92a "Lymphoma, Large B-Cell" 27806315 Primary mediastinal large B-cell lymphoma: transcriptional regulation by miR-92a through FOXP1 targeting. -target gene hsa-mir-940 "Carcinoma, Hepatocellular" 27807540 miR-940 Suppresses Tumor Cell Invasion and Migration via Regulation of CXCR2 in Hepatocellular Carcinoma. -target gene hsa-mir-27b "Carcinoma, Breast" 27809310 Downregulation of microRNA-27b-3p enhances tamoxifen resistance in breast cancer by increasing NR5A2 and CREB1 expression. -target gene hsa-mir-222 Ovarian Neoplasms 27811362 MicroRNA-222-3p/GNAI2/AKT axis inhibits epithelial ovarian cancer cell growth and associates with good overall survival. -target gene hsa-mir-155 "Carcinoma, Lung, Non-Small-Cell" 27811366 "MiR-21 and MiR-155 promote non-small cell lung cancer progression by downregulating SOCS1, SOCS6, and PTEN." -target gene hsa-mir-214 "Carcinoma, Colon" 27811858 The FOXD3/miR-214/MED19 axis suppresses tumour growth and metastasis in human colorectal cancer. -target gene hsa-let-7f Cerebral Ischemia 27812761 Let-7f Regulates the Hypoxic Response in Cerebral Ischemia by Targeting NDRG3. -target gene hsa-mir-34a "Carcinoma, Breast" 27813227 MiR-34a modulates ErbB2 in breast cancer. -target gene hsa-mir-199a "Carcinoma, Bladder" 27814720 miR-199a-5p suppresses human bladder cancer cell metastasis by targeting CCR7. -target gene hsa-mir-542 "Carcinoma, Hepatocellular" 27815069 MicroRNA-542-3p inhibits the growth of hepatocellular carcinoma cells by targeting FZD7/Wnt signaling pathway. -target gene hsa-mir-106a Glioblastoma 27815074 MicroRNA-106a-5p facilitates human glioblastoma cell proliferation and invasion by targeting adenomatosis polyposis coli protein. -target gene hsa-mir-10a "Lymphoma, Large B-Cell, Diffuse" 27815824 miR-10a inhibits cell proliferation and promotes cell apoptosis by targeting BCL6 in diffuse large B-cell lymphoma. -target gene hsa-mir-124 "Carcinoma, Breast" 27815936 MicroRNA-124 enhances response to radiotherapy in human epidermal growth factor receptor 2-positive breast cancer cells by targeting signal transducer and activator of transcription 3. -target gene hsa-mir-1 Neoplasms [unspecific] 27819721 miR-1 association with cell proliferation inhibition and apoptosis in vestibular schwannoma by targeting VEGFA. -target gene hsa-mir-203 Glioblastoma 27820599 Tissue mechanics promote IDH1-dependent HIF1¦Á-tenascin C feedback to regulate glioblastoma?aggression. -target gene hsa-mir-3117 "Carcinoma, Hepatocellular" 27822662 miR-3117 regulates hepatocellular carcinoma cell proliferation by targeting PHLPPL. -target gene hsa-mir-143 "Carcinoma, Colon" 27827523 MicroRNA-143 inhibits colorectal cancer cell proliferation by targeting MMP7. -target gene hsa-mir-639 "Carcinoma, Thyroid" 27829546 MiR-639 promoted cell proliferation and cell cycle in human thyroid cancer by suppressing CDKN1A expression. -target gene hsa-mir-503 Atherosclerosis 27829550 miR-503 inhibits platelet-derived growth factor-induced human aortic vascular smooth muscle cell proliferation and migration through targeting the insulin receptor. -target gene hsa-mir-17 "Carcinoma, Breast" 27831559 Decreased expression of microRNA-17 and microRNA-20b promotes breast cancer resistance to taxol therapy by upregulation of NCOA3. -target gene hsa-mir-20b "Carcinoma, Breast" 27831559 Decreased expression of microRNA-17 and microRNA-20b promotes breast cancer resistance to taxol therapy by upregulation of NCOA3. -target gene hsa-mir-129 "Carcinoma, Breast" 27831649 MiR-129-5p is downregulated in breast cancer cells partly due to promoter H3K27m3 modification and regulates epithelial-mesenchymal transition and multi-drug resistance. -target gene hsa-mir-378a Liver Cirrhosis 27832641 Activation of Hepatic Stellate Cells is Inhibited by microRNA-378a-3p via Wnt10a. -target gene hsa-mir-146a "Squamous Cell Carcinoma, Esophageal" 27832663 miR-146a-5p mediates epithelial-mesenchymal transition of oesophageal squamous cell carcinoma via targeting Notch2. -target gene hsa-mir-199a "Carcinoma, Hepatocellular" 27832779 "miR-199a-3p inhibits cell proliferation and induces apoptosis by targeting YAP1, suppressing Jagged1-Notch signaling in human hepatocellular carcinoma." -target gene hsa-mir-375 "Carcinoma, Prostate" 27832783 miR-375 induces docetaxel resistance in prostate cancer by targeting SEC23A and YAP1. -target gene hsa-mir-22 Astrocytoma 27834627 Promotion of astrocytoma cell invasion by micro RNA-22 targeting of tissue inhibitor of matrix metalloproteinase-2. -target gene hsa-mir-125a Inflammation 27836539 these findings identify a PPAR¦Ã-miR-125a-NOD1 signaling axis in endothelial cells that is critical in the regulation of inflammation-mediated angiogenesis -target gene hsa-mir-34a "Carcinoma, Lung" 27836543 miR-34a sensitizes lung cancer cells to cisplatin via p53/miR-34a/MYCN axis. -target gene hsa-mir-215 Glioma 27837373 MicroRNA-215 enhances invasion and migration by targeting retinoblastoma tumor suppressor gene 1 in high-grade glioma. -target gene hsa-mir-141 "Carcinoma, Lung, Non-Small-Cell" 27840955 miR-141 regulation of EIF4E expression affects docetaxel chemoresistance of non-small cell lung cancer. -target gene hsa-mir-503 "Carcinoma, Hepatocellular" 27840964 miR-503 inhibits proliferation making human hepatocellular carcinoma cells susceptible to 5?fluorouracil by targeting EIF4E. -target gene hsa-mir-34a Cataract 27840975 miR?34a suppresses proliferation and induces apoptosis of human lens epithelial cells by targeting E2F3. -target gene hsa-mir-124 Breast Neoplasms 27842510 miR-124-3p functions as a tumor suppressor in breast cancer by targeting CBL. -target gene hsa-mir-148a Multiple Myeloma 27842905 MiR-148a participates in the growth of RPMI8226 multiple myeloma cells by regulating CDKN1B. -target gene hsa-mir-27b "Carcinoma, Gastric" 27844448 miR-27b inhibits gastric cancer metastasis by targeting NR2F2. -target gene hsa-mir-146a Osteoarthritis 27845876 Hypoxia-induced microRNA-146a represses Bcl-2 through Traf6/IRAK1 but not Smad4 to promote chondrocyte autophagy. -target gene hsa-mir-33a "Carcinoma, Lung, Non-Small-Cell" 27856248 MiR-33a suppresses proliferation of NSCLC cells via targeting METTL3 mRNA. -target gene hsa-mir-16 Colorectal Carcinoma 27857191 Deregulation of the miR-16-KRAS axis promotes colorectal cancer. -target gene hsa-mir-383 "Carcinoma, Lung" 27862077 MicroRNA-383 is a tumor suppressor in human lung cancer by targeting endothelial PAS domain-containing protein 1. -target gene hsa-mir-187 "Carcinoma, Gastric" 27864146 MicroRNA-187 regulates gastric cancer progression by targeting the tumor suppressor CRMP1. -target gene hsa-mir-335 "Carcinoma, Lung, Small-Cell" 27871924 MiR-335 regulates the chemo-radioresistance of small cell lung cancer cells by targeting PARP-1. -target gene hsa-mir-377 "Carcinoma, Lung, Non-Small-Cell" 27874949 miR-377 inhibited tumorous behaviors of non-small cell lung cancer through directly targeting CDK6. -target gene hsa-mir-194 "Carcinoma, Gastric" 27874950 miR-194 inhibits gastric cancer cell proliferation and tumorigenesis by targeting KDM5B. -target gene hsa-mir-373 "Lymphoma, T-Cell" 27874957 Restoration of microRNA-373 suppresses growth of human T-cell lymphoma cells by repressing CCND1. -target gene hsa-mir-137 "Carcinoma, Ovarian" 27875524 microRNA-137 promotes apoptosis in ovarian cancer cells via the regulation of XIAP. -target gene hsa-mir-371 Lupus Nephritis 27878241 Hsa?miR?371?5p inhibits human mesangial cell proliferation and promotes apoptosis in lupus nephritis by directly targeting hypoxia?inducible factor 1¦Á. -target gene hsa-mir-200b "Carcinoma, Pancreatic" 27878247 Oridonin inhibition and miR?200b?3p/ZEB1 axis in human pancreatic cancer. -target gene hsa-mir-362 "Carcinoma, Cervical" 27878258 "MicroRNA-362 is downregulated in cervical cancer and inhibits cell proliferation, migration and invasion by directly targeting SIX1." -target gene hsa-mir-3619 "Carcinoma, Prostate" 27878260 miR-3619-5p inhibits prostate cancer cell growth by activating CDKN1A expression. -target gene hsa-mir-638 "Carcinoma, Hepatocellular" 27878280 Loss of miR-638 promotes invasion and epithelial-mesenchymal transition by targeting SOX2 in hepatocellular carcinoma. -target gene hsa-mir-148a "Carcinoma, Renal Cell" 27878305 miR-148a suppresses human renal cell carcinoma malignancy by targeting AKT2. -target gene hsa-mir-429 "Carcinoma, Cervical" 27883176 miR-429 is involved in regulation of NF-¦ÊBactivity by targeting IKK¦Â and suppresses oncogenic activity in cervical cancer cells. -target gene hsa-mir-421 "Carcinoma, Cervical" 27886335 microRNA 421 induces apoptosis of c-33a cervical cancer cells via down-regulation of Bcl-xL. -target gene hsa-mir-202 "Adenocarcinoma, Lung" 27887846 Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 regulates the expression of Gli2 by miR-202 to strengthen gastric cancer progression. -target gene hsa-mir-136 "Carcinoma, Ovarian" 27887917 MicroRNA-136 inhibits cancer stem cell activity and enhances the anti-tumor effect of paclitaxel against chemoresistant ovarian cancer cells by targeting Notch3. -target gene hsa-mir-24 Colon Neoplasms 27888625 "TRIM11, a direct target of miR-24-3p, promotes cell proliferation and inhibits apoptosis in colon cancer." -target gene hsa-let-7g Pulmonary Hypertension 27889560 MicroRNA let-7g inhibited hypoxia-induced proliferation of PASMCs via G0/G1 cell cycle arrest by targeting c-myc. -target gene hsa-mir-22 "Leukemia, Myeloid, Chronic" 27889568 FosB regulates expression of miR-22 during PMA induced differentiation of K562?cells to megakaryocytes. -target gene hsa-mir-181 "Leukemia, T-Cell" 27889686 MicroRNA-181 contributes to downregulation of SAMHD1 expression in CD4+ T-cells derived from S¨¨zary syndrome patients. -target gene hsa-mir-146a Dermatomyositis 27889748 MiR-146a Regulates Inflammatory Infiltration by Macrophages in Polymyositis/Dermatomyositis by Targeting TRAF6 and Affecting IL-17/ICAM-1 Pathway. -target gene hsa-mir-98 "Carcinoma, Hepatocellular" 27890434 miR-98 inhibits hepatocellular carcinoma cell proliferation via targeting EZH2 and suppressing Wnt/¦Â-catenin signaling pathway. -target gene hsa-mir-383 "Carcinoma, Prostate" 27893706 MicroRNA-383 located in frequently deleted chromosomal locus 8p22 regulates CD44 in prostate cancer. -target gene hsa-mir-214 Ischemia-Reperfusion Injury 27894079 MicroRNA-214 protects against hypoxia/reoxygenation induced cell damage and myocardial ischemia/reperfusion injury via suppression of PTEN and Bim1 expression. -target gene hsa-mir-509 "Carcinoma, Lung, Non-Small-Cell" 27894843 "MiR-509-5p suppresses the proliferation, migration, and invasion of non-small cell lung cancer by targeting YWHAG." -target gene hsa-mir-9 Melanoma 27895497 "MicroRNA-9 suppresses the growth, migration, and invasion of malignant melanoma cells via targeting NRP1." -target gene hsa-mir-15b Glioblastoma 27896672 miR-15b Inhibits the Progression of Glioblastoma Cells Through Targeting Insulin-like Growth Factor Receptor 1. -target gene hsa-mir-26a Prostate Neoplasms 27900011 Downregulated microRNA-26a modulates prostate cancer cell proliferation and apoptosis by targeting COX-2. -target gene hsa-mir-150 Osteosarcoma 27900020 MicroRNA-150 upregulation reduces osteosarcoma cell invasion and metastasis by downregulating Ezrin. -target gene hsa-mir-138 Cervical Neoplasms 27900047 "MicroRNA-138 inhibits proliferation, migration and invasion through targeting hTERT in cervical cancer." -target gene hsa-mir-31 Colitis 27901018 The signaling axis of microRNA-31/interleukin-25 regulates Th1/Th17-mediated inflammation response in colitis. -target gene hsa-mir-145 Asthma 27902892 MicroRNA-145 influences the balance of Th1/Th2 via regulating RUNX3 in asthma patients. -target gene hsa-mir-125b Myeloma 27903272 "BETi-mediated inhibition of cMYC correlates with the upregulation of miR-125b-5p and the downregulation of the cMYC/miR-125b-5p target gene IRF4, a transcriptional repressor of MICA" -target gene hsa-mir-206 Bladder Neoplasms 27904673 MicroRNA-206 acts as a tumor suppressor in bladder cancer via targeting YRDC. -target gene hsa-mir-101 "Squamous Cell Carcinoma, Oral" 27904690 miRNA-101 acts as a tumor suppressor in oral squamous cell carcinoma by targeting CX chemokine receptor 7. -target gene hsa-mir-491 Glioma 27905892 miR-491 regulates glioma cells proliferation by targeting TRIM28 in vitro. -target gene hsa-mir-140 Gout 27906093 microRNA -140-5p inhibits colorectal cancer invasion and metastasis by targeting ADAMTS5 and IGFBP5. -target gene hsa-mir-185 "Carcinoma, Lung, Non-Small-Cell" 27906433 MicroRNA-185-5p modulates chemosensitivity of human non-small cell lung cancer to cisplatin via targeting ABCC1. -target gene hsa-mir-451 Osteosarcoma 27908732 "miR-451 inhibits cell growth, migration and angiogenesis in human osteosarcoma via down-regulating IL 6R." -target gene hsa-mir-146a Vascular Disease [unspecific] 27908889 MicroRNA-146a Induces Lineage-Negative Bone Marrow Cell Apoptosis and Senescence by Targeting Polo-Like Kinase 2 Expression. -target gene hsa-mir-101 Glioblastoma 27911279 "MicroRNA-101 inhibits proliferation, migration and invasion of human glioblastoma by targeting SOX9." -target gene hsa-mir-346 "Carcinoma, Breast" 27913185 MiR-346 promotes the biological function of breast cancer cells by targeting SRCIN1 and reduces chemosensitivity to docetaxel. -target gene hsa-mir-181a Keloid 27915346 MiR-181a Targets PHLPP2 to Augment AKT Signaling and Regulate Proliferation and Apoptosis in Human Keloid Fibroblasts. -target gene hsa-mir-21 Lung Fibrosis 27916096 miR-21 promotes pulmonary fibrosis in rats via down-regulating the expression of ADAMTS-1. -target gene hsa-mir-217 "Carcinoma, Breast" 27916422 PGC-1 alpha interacts with microRNA-217 to functionally regulate breast cancer cell proliferation. -target gene hsa-mir-223 Colorectal Carcinoma 27916606 FBX8 is a metastasis suppressor downstream of miR-223 and targeting mTOR for degradation in colorectal carcinoma. -target gene hsa-mir-139 "Carcinoma, Breast" 27916718 Loss of the Opa interacting protein 5 inhibits breast cancer proliferation through miR-139-5p/NOTCH1 pathway. -target gene hsa-mir-15a Osteoarthritis 27916780 MiR-15a-5p regulates viability and matrix degradation of human osteoarthritis chondrocytes via targeting VEGFA. -target gene hsa-mir-33a "Carcinoma, Prostate" 27921232 Biological function and mechanism of miR-33a in prostate cancer survival and metastasis: via downregulating Engrailed-2. -target gene hsa-mir-145 Osteoarthritis 27922673 Effects of miR-145 on the inhibition of chondrocyte proliferation and fibrosis by targeting TNFRSF11B in human osteoarthritis. -target gene hsa-mir-152 "Carcinoma, Hepatocellular" 27922690 MicroRNA-152 inhibits tumor cell growth by directly targeting RTKN in hepatocellular carcinoma. -target gene hsa-mir-211 "Carcinoma, Cervical" 27923652 MiR-211 inhibits invasion and epithelial-to-mesenchymal transition (EMT) of cervical cancer cells via targeting MUC4. -target gene hsa-mir-483 Kawasaki Syndrome 27923814 miR-483 Targeting of CTGF Suppresses Endothelial-to-Mesenchymal Transition: Therapeutic Implications in Kawasaki Disease. -target gene hsa-mir-124 "Carcinoma, Lung, Non-Small-Cell" 27924500 miR-124 modulates gefitinib resistance through SNAI2 and STAT3 in non-small cell lung cancer. -target gene hsa-mir-206 "Carcinoma, Renal Cell" 27924503 miR-206 inhibits renal cell cancer growth by targeting GAK. -target gene hsa-mir-205 Cervical Neoplasms 27929537 Upregulation of MiR-205 under hypoxia promotes epithelial-mesenchymal transition by targeting ASPP2. -target gene hsa-mir-205 Lung Neoplasms 27929537 Upregulation of MiR-205 under hypoxia promotes epithelial-mesenchymal transition by targeting ASPP2. -target gene hsa-mir-151 "Carcinoma, Breast" 27930738 miR-151-3p Targets TWIST1 to Repress Migration of Human Breast Cancer Cells. -target gene hsa-mir-200c "Carcinoma, Lung, Non-Small-Cell" 27930974 miR-200c enhances sensitivity of drug-resistant non-small cell lung cancer to gefitinib by suppression of PI3K/Akt signaling pathway and inhibites cell migration via targeting ZEB1. -target gene hsa-let-7a "Carcinoma, Hepatocellular" 27932893 Let-7a enhances the sensitivity of hepatocellular carcinoma cells to cetuximab by regulating STAT3 expression. -target gene hsa-mir-145 "Carcinoma, Cervical" 27933466 "microRNA-145 modulates epithelial-mesenchymal transition and suppresses proliferation, migration and invasion by targeting SIP1 in human cervical cancer cells." -target gene hsa-mir-125b Preeclampsia 27935985 miR-125b Enhances IL-8 Production in Early-Onset Severe Preeclampsia by Targeting Sphingosine-1-Phosphate Lyase 1. -target gene hsa-mir-138 Psoriasis 27936398 MicroRNA138 regulates keratin 17 protein expression to affect HaCaT cell proliferation and apoptosis by targeting hTERT in psoriasis vulgaris. -target gene hsa-mir-23a Rheumatoid Arthritis 27936459 MiR-23a inhibited IL-17-mediated proinflammatory mediators expression via targeting IKK¦Á in articular chondrocytes. -target gene hsa-mir-181b Glioma 27938503 MicroRNA-181b Inhibits Cellular Proliferation and Invasion of Glioma Cells via Targeting Sal-Like Protein 4. -target gene hsa-mir-98 "Carcinoma, Lung, Non-Small-Cell" 27938506 MicroRNA-98 Plays a Suppressive Role in Non-Small Cell Lung Cancer Through Inhibition of SALL4 Protein Expression. -target gene hsa-mir-150 Systemic Lupus Erythematosus 27940256 Enhanced expression of TREM-1 in splenic cDCs in lupus prone mice and it was modulated by miRNA-150. -target gene hsa-mir-141 "Carcinoma, Prostate" 27956179 MiR-141-3p promotes prostate cancer cell proliferation through inhibiting kruppel-like factor-9 expression. -target gene hsa-mir-7 "Squamous Cell Carcinoma, Esophageal" 27956498 "In cytoplasm, CCAT1 regulates HOXB13 as a molecular decoy for miR-7, a microRNA that targets both CCAT1 and HOXB13, thus facilitating cell growth and migration" -target gene hsa-mir-194 "Carcinoma, Prostate" 27959429 MicroRNA-194 suppresses prostate cancer migration and invasion by downregulating human nuclear distribution protein. -target gene hsa-mir-326 Neoplasms [unspecific] 27960279 Resveratrol Induces Cancer Cell Apoptosis through MiR-326/PKM2-Mediated ER Stress and Mitochondrial Fission. -target gene hsa-mir-320a Polycystic Ovarian Syndrome 27965096 Deregulation of RUNX2 by miR-320a deficiency impairs steroidogenesis in cumulus granulosa cells from polycystic ovary syndrome (PCOS) patients. -target gene hsa-mir-451a Cardiomyopathy 27974462 Down-regulation of microRNA-451a facilitates the activation and proliferation of CD4+ T cells by targeting Myc in patients with dilated cardiomyopathy. -target gene hsa-mir-124 Inflammatory Bowel Diseases 27977009 Downregulated expression of microRNA-124 in pediatric intestinal failure patients modulates macrophages activation by inhibiting STAT3 and AChE. -target gene hsa-mir-138 "Carcinoma, Bladder" 27978829 miR-138-5p contributes to cell proliferation and invasion by targeting Survivin in bladder cancer cells. -target gene hsa-mir-200b Inflammatory Bowel Diseases 27979826 miR-200b inhibits TNF-¦Á-induced IL-8 secretion and tight junction disruption of intestinal epithelial cells in vitro. -target gene hsa-mir-200a "Carcinoma, Colon" 27983967 MiR-200a acts as an oncogene in colorectal carcinoma by targeting PTEN. -target gene hsa-mir-494 "Carcinoma, Ovarian" 27983981 CUL4A functions as an oncogene in ovarian cancer and is directly regulated by miR-494. -target gene hsa-mir-130a "Carcinoma, Prostate" 27984115 Epigenetic disruption of miR-130a promotes prostate cancer by targeting SEC23B and DEPDC1. -target gene hsa-mir-497 Heart Failure 27992564 MicroRNA-497 Inhibits Cardiac Hypertrophy by Targeting Sirt4. -target gene hsa-mir-126 Atherosclerosis 27993686 MicroRNA-126 suppresses inflammation in endothelial cells under hyperglycemic condition by targeting HMGB1. -target gene hsa-mir-506 "Carcinoma, Colon" 27993882 MicroRNA-506 Inhibits Malignancy of Colorectal Carcinoma Cells by Targeting LAMC1. -target gene hsa-mir-29c Breast Neoplasms 27994679 Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells. -target gene hsa-mir-22 Heart Failure 27997889 MiR-22 may Suppress Fibrogenesis by Targeting TGF¦ÂR I in Cardiac Fibroblasts. -target gene hsa-mir-520b "Carcinoma, Gastric" 27997901 MiR-520b/e Regulates Proliferation and Migration by Simultaneously Targeting EGFR in Gastric Cancer. -target gene hsa-mir-520e "Carcinoma, Gastric" 27997901 MiR-520b/e Regulates Proliferation and Migration by Simultaneously Targeting EGFR in Gastric Cancer. -target gene hsa-mir-143 "Carcinoma, Cervical" 27998464 miR-143 inhibits cell proliferation through targeted regulating the expression of K-ras gene in HeLa cells. -target gene hsa-mir-340 "Carcinoma, Hepatocellular" 27998770 MicroRNA-340 inhibits the proliferation and invasion of hepatocellular carcinoma cells by targeting JAK1. -target gene hsa-mir-130a Osteoarthritis 27999816 "miR-204, which targets RUNX2, and miR-130a, which inhibits PPAR¦Ã, were lower and higher, respectively, in F versus OA serum samples" -target gene hsa-mir-204 Osteoarthritis 27999816 "miR-204, which targets RUNX2, and miR-130a, which inhibits PPAR¦Ã, were lower and higher, respectively, in F versus OA serum samples" -target gene hsa-mir-487b Colorectal Carcinoma 28000854 Identification of microRNA-487b as a negative regulator of liver metastasis by regulation of KRAS in colorectal cancer. -target gene hsa-mir-101 Colorectal Carcinoma 28000868 Methyl jasmonate induces the apoptosis of human colorectal cancer cells via downregulation of EZH2 expression by microRNA?101. -target gene hsa-mir-1290 "Leukemia, Lymphoblastic, Acute" 28000876 miR-196b/miR-1290 participate in the antitumor effect of resveratrol via regulation of IGFBP3 expression in acute lymphoblastic leukemia. -target gene hsa-mir-196b Leukemia 28000876 miR-196b/miR-1290 participate in the antitumor effect of resveratrol via regulation of IGFBP3 expression in acute lymphoblastic leukemia. -target gene hsa-mir-302a Glioma 28000880 "MicroRNA-302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma." -target gene hsa-mir-152 "Carcinoma, Nasopharyngeal" 28000885 "MicroRNA?152 inhibits cell proliferation, migration and invasion by directly targeting MAFB in nasopharyngeal carcinoma." -target gene hsa-mir-631 Multiple Myeloma 28000886 hsa-miR-631 resensitizes bortezomib-resistant multiple myeloma cell lines by inhibiting UbcH10. -target gene hsa-mir-26a "Adenocarcinoma, Lung" 28000891 Expression of miR?26a exhibits a negative correlation with HMGA1 and regulates cancer progression by targeting HMGA1 in lung adenocarcinoma cells. -target gene hsa-mir-223 Testicular Germ Cell Tumor 28000896 miR?223?3p regulates cell growth and apoptosis via FBXW7 suggesting an oncogenic role in human testicular germ cell tumors. -target gene hsa-mir-367 "Carcinoma, Lung, Non-Small-Cell" 28000899 miR-367 promotes the proliferation and invasion of non-small cell lung cancer via targeting FBXW7. -target gene hsa-mir-24 "Carcinoma, Bladder" 28000900 "miR-24-3p regulates bladder cancer cell proliferation, migration, invasion and autophagy by targeting DEDD." -target gene hsa-mir-375 "Squamous Cell Carcinoma, Oral" 28000902 MicroRNA?375 inhibits oral squamous cell carcinoma cell migration and invasion by targeting platelet?derived growth factor?A. -target gene hsa-mir-221 Neuroblastoma 28003306 microRNA-221 Enhances MYCN via Targeting Nemo-like Kinase and Functions as an Oncogene Related to Poor Prognosis in Neuroblastoma. -target gene hsa-mir-20a Colorectal Carcinoma 28004114 miR-20a-directed regulation of BID is associated with the TRAIL sensitivity in colorectal cancer. -target gene hsa-mir-592 "Carcinoma, Lung, Non-Small-Cell" 28004116 miR-592 functions as a tumor suppressor in human non-small cell lung cancer by targeting SOX9. -target gene hsa-mir-382 "Carcinoma, Lung, Non-Small-Cell" 28006750 miR-382 inhibits tumor progression by targeting SETD8 in non-small cell lung cancer. -target gene hsa-mir-155 Ischemia-Reperfusion Injury 28006785 MiR-155 is Involved in Renal Ischemia-Reperfusion Injury via Direct Targeting of FoxO3a and Regulating Renal Tubular Cell Pyroptosis. -target gene hsa-mir-215 Hirschsprung Disease 28006787 Role of MiR-215 in Hirschsprung's Disease Pathogenesis by Targeting SIGLEC-8. -target gene hsa-mir-320a "Carcinoma, Gastric" 28008607 "MicroRNA-320a and microRNA-4496 attenuate Helicobacter pylori cytotoxin-associated gene A (CagA)-induced cancer-initiating potential and chemoresistance by targeting ¦Â-catenin and ATP-binding cassette, subfamily G, member 2." -target gene hsa-mir-4496 "Carcinoma, Gastric" 28008607 "MicroRNA-320a and microRNA-4496 attenuate Helicobacter pylori cytotoxin-associated gene A (CagA)-induced cancer-initiating potential and chemoresistance by targeting ¦Â-catenin and ATP-binding cassette, subfamily G, member 2." -target gene hsa-mir-194 "Carcinoma, Prostate" 28011622 MicroRNA-194 Promotes Prostate Cancer Metastasis by Inhibiting SOCS2. -target gene hsa-mir-3941 "Adenocarcinoma, Lung" 28012229 miR-3941: A novel microRNA that controls IGBP1 expression and is associated with malignant progression of lung adenocarcinoma. -target gene hsa-mir-381 "Carcinoma, Breast" 28012397 "miR-381 inhibited breast cancer cells proliferation, epithelial-to-mesenchymal transition and metastasis by targeting CXCR4." -target gene hsa-mir-129 "Carcinoma, Gastric" 28012924 MiR-129 regulates cisplatin-resistance in human gastric cancer cells by targeting P-gp. -target gene hsa-mir-590 "Adenocarcinoma, Lung" 28012926 miR-590 accelerates lung adenocarcinoma migration and invasion through directly suppressing functional target OLFM4. -target gene hsa-mir-149 "Leukemia, Myeloid, Acute" 28013316 Inhibition of MicroRNA-149-5p Induces Apoptosis of Acute Myeloid Leukemia Cell Line THP-1 by Targeting Fas Ligand (FASLG). -target gene hsa-mir-98 "Carcinoma, Colon" 28025745 MicroRNA-98 Suppress Warburg Effect by Targeting HK2 in Colon Cancer Cells. -target gene hsa-mir-33b "Carcinoma, Hepatocellular" 28026002 MicroRNA-33b suppresses the proliferation and metastasis of hepatocellular carcinoma cells through the inhibition of Sal-like protein 4 expression. -target gene hsa-mir-19b Antiphospholipid Syndrome 28028298 MicroRNA expression in antiphospholipid syndrome: a systematic review and microRNA target genes analysis. -target gene hsa-mir-20a Antiphospholipid Syndrome 28028298 MicroRNA expression in antiphospholipid syndrome: a systematic review and microRNA target genes analysis. -target gene hsa-mir-200b "Carcinoma, Prostate" 28028835 TIMP4 expression is regulated by miR-200b-3p in prostate cancer cells. -target gene hsa-mir-200c Neoplasms [unspecific] 28029649 MiR-200c is a cMyc-activated miRNA that promotes nasopharyngeal carcinoma by downregulating PTEN. -target gene hsa-mir-195 Osteosarcoma 28032380 MicroRNA-195-5p suppresses osteosarcoma cell proliferation and invasion by suppressing naked cuticle homolog 1. -target gene hsa-mir-216a "Carcinoma, Pancreatic" 28034748 "MiR-216a decreases MALAT1 expression, induces G2/M arrest and apoptosis in pancreatic cancer cells." -target gene hsa-mir-137 "Carcinoma, Colon" 28035913 MicroRNA-137 chemosensitizes colon cancer cells to the chemotherapeutic drug oxaliplatin (OXA) by targeting YBX1. -target gene hsa-mir-603 "Carcinoma, Breast, Triple Negative" 28036267 MicroRNA 603 acts as a tumor suppressor and inhibits triple-negative breast cancer tumorigenesis by targeting elongation factor 2 kinase. -target gene hsa-mir-224 Pancreatic Neoplasms 28036293 A retrospective study of NENs and miR-224 promotes apoptosis of BON-1 cells by targeting PCSK9 inhibition. -target gene hsa-mir-96 "Diabetes Mellitus, Type 2" 28036389 Induction of miR-96 by Dietary Saturated Fatty Acids Exacerbates Hepatic Insulin Resistance through the Suppression of INSR and IRS-1. -target gene hsa-mir-10b Ankylosing Spondylitis 28039186 miR-10b-5p is a novel Th17 regulator present in Th17 cells from ankylosing spondylitis. -target gene hsa-mir-194 Psoriasis 28040329 MicroRNA-194 regulates keratinocyte proliferation and differentiation by targeting Grainyhead-like 2 in psoriasis. -target gene hsa-mir-124 Glioblastoma 28040710 REST represses miR-124 and miR-203 to regulate distinct oncogenic properties of glioblastoma stem cells. -target gene hsa-mir-203 Glioblastoma 28040710 REST represses miR-124 and miR-203 to regulate distinct oncogenic properties of glioblastoma stem cells. -target gene hsa-mir-130b "Carcinoma, Bladder" 28042869 Genome-Wide Screen of miRNAs and Targeting mRNAs Reveals the Negatively Regulatory Effect of miR-130b-3p on PTEN by PI3K and Integrin ¦Â1 Signaling Pathways in Bladder Carcinoma. -target gene hsa-mir-486 Leukemia 28043832 Exosomal miR-486 regulates hypoxia-induced erythroid differentiation of erythroleukemia cells through targeting Sirt1. -target gene hsa-mir-181a "Carcinoma, Gastric" 28043911 miR-181a-5p promotes the progression of gastric cancer via RASSF6-mediated MAPK signalling activation. -target gene hsa-mir-134 "Carcinoma, Ovarian" 28043921 MicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A. -target gene hsa-mir-330 "Carcinoma, Hepatocellular" 28050784 Roles of microRNA-330 and Its Target Gene ING4 in the Development of Aggressive Phenotype in Hepatocellular Carcinoma Cells. -target gene hsa-mir-204 "Carcinoma, Prostate" 28050800 Micro-RNA-204 Participates in TMPRSS2/ERG Regulation and Androgen Receptor Reprogramming in Prostate Cancer. -target gene hsa-mir-365 Atherosclerosis 28051250 MiR-365 participates in coronary atherosclerosis through regulating IL-6. -target gene hsa-mir-145 Osteosarcoma 28051259 "MicroRNA-145 inhibits tumour growth and metastasis in osteosarcoma by targeting cyclin-dependent kinase, CDK6." -target gene hsa-mir-138 "Carcinoma, Pancreatic" 28052003 miR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1. -target gene hsa-mir-761 "Carcinoma, Breast, Triple Negative" 28054302 microRNA-761 induces aggressive phenotypes in triple-negative breast cancer cells by repressing TRIM29 expression. -target gene hsa-mir-223 Rheumatoid Arthritis 28056105 miR-223-3p may contribute to the pathogenesis of RA by downregulating the expression of IL-17RD and upregulating that of IL-6 in synovial cells -target gene hsa-mir-93 Osteosarcoma 28056303 MiR-93 targets NKD2 to promote proliferation and inhibit apoptosis of osteosarcoma cells -target gene hsa-let-7a Neoplasms [unspecific] 28057739 the let-7-HMGA2 axis plays a prominent role in the pathogenesis of the disease that leads to unique clinical phenotypes -target gene hsa-mir-92a "Leukemia, Myeloid, Acute" 28059050 miR-92a Inhibits Proliferation and Induces Apoptosis by Regulating Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) Expression in Acute Myeloid Leukemia. -target gene hsa-let-7a Heart Failure 28060734 Let-7a regulates expression of ¦Â1-adrenoceptors and forms a negative feedback circuit with the ¦Â1-adrenoceptor signaling pathway in chronic ischemic heart failure. -target gene hsa-mir-107 Acute Kidney Failure 28063928 MiR-107 induces TNF-¦Á secretion in endothelial cells causing tubular cell injury in patients with septic acute kidney injury. -target gene hsa-mir-148a "Carcinoma, Breast" 28063929 MiR-148a and miR-152 reduce tamoxifen resistance in ER+ breast cancer via downregulating ALCAM. -target gene hsa-mir-152 "Carcinoma, Breast" 28063929 MiR-148a and miR-152 reduce tamoxifen resistance in ER+ breast cancer via downregulating ALCAM. -target gene hsa-mir-129 Glioblastoma 28068630 "Potential mechanisms of microRNA-129-5p in inhibiting cell processes including viability, proliferation, migration and invasiveness of glioblastoma cells U87 through targeting FNDC3B." -target gene hsa-mir-202 "Scleroderma, Systemic" 28068631 MicroRNA-202-3p regulates scleroderma fibrosis by targeting matrix metalloproteinase 1. -target gene hsa-mir-495 "Carcinoma, Bladder" 28069380 microRNA-495 promotes bladder cancer cell growth and invasion by targeting phosphatase and tensin homolog. -target gene hsa-mir-375 "Squamous Cell Carcinoma, Esophageal" 28069583 MiR-375 suppresses invasion and metastasis by direct targeting of SHOX2 in esophageal squamous cell carcinoma. -target gene hsa-mir-150 Osteosarcoma 28070040 MicroRNA-150 inhibits osteosarcoma cell proliferation by targeting RUNX2 gene. -target gene hsa-mir-718 "Carcinoma, Hepatocellular" 28070994 "Involvement of microRNA-718, a new regulator of EGR3, in regulation of malignant phenotype of HCC cells." -target gene hsa-mir-34c Osteosarcoma 28075441 miR?34c?3p acts as a tumor suppressor gene in osteosarcoma by targeting MARCKS. -target gene hsa-mir-191 "Carcinoma, Lung, Non-Small-Cell" 28075452 "A novel pathway in NSCLC cells: miR?191, targeting NFIA, is induced by chronic hypoxia, and promotes cell proliferation and migration." -target gene hsa-mir-375 "Carcinoma, Breast" 28075453 miR-375 inhibits cancer stem cell phenotype and tamoxifen resistance by degrading HOXB3 in human ER-positive breast cancer. -target gene hsa-mir-138 "Carcinoma, Nasopharyngeal" 28075468 MicroRNA-138-5p controls sensitivity of nasopharyngeal carcinoma to radiation by targeting EIF4EBP1. -target gene hsa-mir-134 "Carcinoma, Lung, Non-Small-Cell" 28075475 miR-134 suppresses the migration and invasion of non?small cell lung cancer by targeting ITGB1. -target gene hsa-mir-214 "Carcinoma, Lung, Non-Small-Cell" 28076844 Sulforaphane inhibits cancer stem-like cell properties and cisplatin resistance through miR-214-mediated downregulation of c-MYC in non-small cell lung cancer. -target gene hsa-mir-15a Intervertebral Disc Degeneration 28081468 Role of miR-15a in intervertebral disc degeneration through targeting MAP3K9. -target gene hsa-mir-200a "Carcinoma, Hepatocellular" 28081727 MicroRNA-200a Suppresses Cell Invasion and Migration by Directly Targeting GAB1 in Hepatocellular Carcinoma. -target gene hsa-mir-377 "Carcinoma, Hepatocellular" 28081730 MicroRNA-377 Downregulates Bcl-xL and Increases Apoptosis in Hepatocellular Carcinoma Cells. -target gene hsa-mir-17 Glioma 28081732 Inhibition of Beclin-1-Mediated Autophagy by MicroRNA-17-5p Enhanced the Radiosensitivity of Glioma Cells. -target gene hsa-mir-214 Osteosarcoma 28081735 miR-214-5p Targets ROCK1 and Suppresses Proliferation and Invasion of Human Osteosarcoma Cells. -target gene hsa-mir-940 "Carcinoma, Ovarian" 28081739 miR-940 Upregulation Suppresses Cell Proliferation and Induces Apoptosis by Targeting PKC-¦Ä in Ovarian Cancer OVCAR3 Cells. -target gene hsa-mir-424 "Carcinoma, Cervical" 28082020 miR424-5p functions as an anti-oncogene in cervical cancer cell growth by targeting KDM5B via the Notch signaling pathway. -target gene hsa-mir-125b Inflammatory Bowel Diseases 28082316 miR-16 and miR-125b are involved in barrier function dysregulation through the modulation of claudin-2 and cingulin expression in the jejunum in IBS with diarrhoea. -target gene hsa-mir-16 Inflammatory Bowel Diseases 28082316 miR-16 and miR-125b are involved in barrier function dysregulation through the modulation of claudin-2 and cingulin expression in the jejunum in IBS with diarrhoea. -target gene hsa-mir-23b Chondrosarcoma 28085008 Inhibition of Src by microRNA-23b increases the cisplatin sensitivity of chondrosarcoma cells. -target gene hsa-mir-130a Psoriasis 28085489 microRNA-130a Promotes Human Keratinocyte Viability and Migration and Inhibits Apoptosis Through Direct Regulation of STK40-Mediated NF-¦ÊB Pathway and Indirect Regulation of SOX9-Meditated JNK/MAPK Pathway: A Potential Role in Psoriasis. -target gene hsa-mir-451 Osteosarcoma 28086136 "MiR-451 suppresses proliferation, migration and promotes apoptosis of the human osteosarcoma by targeting macrophage migration inhibitory factor." -target gene hsa-mir-1307 "Carcinoma, Ovarian" 28086946 MiR-1307 promotes ovarian cancer cell chemoresistance by targeting the ING5 expression. -target gene hsa-mir-449a Liver Neoplasms 28088579 The microRNA-449 family inhibits TGF-¦Â-mediated liver cancer cell migration by targeting SOX4. -target gene hsa-mir-449b Liver Neoplasms 28088579 The microRNA-449 family inhibits TGF-¦Â-mediated liver cancer cell migration by targeting SOX4. -target gene hsa-mir-30c "Fatty Liver, Non-Alcoholic" 28088781 MiR-30c-5p ameliorates hepatic steatosis in leptin receptor-deficient (db/db) mice via down-regulating FASN. -target gene hsa-mir-195 "Carcinoma, Renal Cell, Clear-Cell" 28089832 Androgen receptor (AR) promotes clear cell renal cell carcinoma (ccRCC) migration and invasion via altering the circHIAT1/miR-195-5p/29a-3p/29c-3p/CDC42 signals. -target gene hsa-mir-29a "Carcinoma, Renal Cell, Clear-Cell" 28089832 Androgen receptor (AR) promotes clear cell renal cell carcinoma (ccRCC) migration and invasion via altering the circHIAT1/miR-195-5p/29a-3p/29c-3p/CDC42 signals. -target gene hsa-mir-29c "Carcinoma, Renal Cell, Clear-Cell" 28089832 Androgen receptor (AR) promotes clear cell renal cell carcinoma (ccRCC) migration and invasion via altering the circHIAT1/miR-195-5p/29a-3p/29c-3p/CDC42 signals. -target gene hsa-mir-141 "Carcinoma, Ovarian" 28095864 MicroRNA-141 enhances anoikis resistance in metastatic progression of ovarian cancer through targeting KLF12/Sp1/survivin axis. -target gene hsa-mir-155 Human Immunodeficiency Virus Infection 28096489 "miR-155 and miR-92a, were reported previously to at least weakly bind HIV-1 transcripts" -target gene hsa-mir-92a Human Immunodeficiency Virus Infection 28096489 "miR-155 and miR-92a, were reported previously to at least weakly bind HIV-1 transcripts" -target gene hsa-mir-345 "Carcinoma, Hepatocellular" 28098858 miR-345 inhibits tumor metastasis and EMT by targeting IRF1-mediated mTOR/STAT3/AKT pathway in hepatocellular carcinoma. -target gene hsa-mir-34b "Carcinoma, Hepatocellular" 28098861 Triptolide inhibits viability and induces apoptosis in liver cancer cells through activation of the tumor suppressor gene p53. -target gene hsa-mir-34c "Carcinoma, Hepatocellular" 28098861 Triptolide inhibits viability and induces apoptosis in liver cancer cells through activation of the tumor suppressor gene p53. -target gene hsa-mir-187 "Carcinoma, Gastric" 28098868 MicroRNA-187 promotes growth and metastasis of gastric cancer by inhibiting FOXA2. -target gene hsa-mir-148a "Carcinoma, Renal Cell" 28098870 miR-148a increases the sensitivity to cisplatin by targeting Rab14 in renal cancer cells. -target gene hsa-mir-375 "Carcinoma, Lung, Non-Small-Cell" 28098887 miRNA?375 regulates the cell survival and apoptosis of human non?small cell carcinoma by targeting HER2. -target gene hsa-mir-194 Glioma 28098896 MicroRNA-194 represses glioma cell epithelial?to?mesenchymal transition by targeting Bmi1. -target gene hsa-mir-9 Liver Cirrhosis 28098912 MicroRNA-9 limits hepatic fibrosis by suppressing the activation and proliferation of hepatic stellate cells by directly targeting MRP1/ABCC1. -target gene hsa-mir-1296 "Carcinoma, Gastric" 28099468 miR 1296-5p Inhibits the Migration and Invasion of Gastric Cancer Cells by Repressing ERBB2 Expression. -target gene hsa-mir-27a "Carcinoma, Breast" 28099945 "In vivo and in vitro effects of microRNA-27a on proliferation, migration and invasion of breast cancer cells through targeting of SFRP1 gene via Wnt/¦Â-catenin signaling pathway." -target gene hsa-mir-221 "Squamous Cell Carcinoma, Oral" 28101204 Downregulation of miR-221/222 by a microRNA sponge promotes apoptosis in oral squamous cell carcinoma cells through upregulation of PTEN. -target gene hsa-mir-222 "Squamous Cell Carcinoma, Oral" 28101204 Downregulation of miR-221/222 by a microRNA sponge promotes apoptosis in oral squamous cell carcinoma cells through upregulation of PTEN. -target gene hsa-mir-15a "Leukemia, Lymphoblastic, Acute, B-Cell" 28101583 we proposed a cellular model to discuss MYC/miR-15a-5p/FLT3 feed-forward loop?(FFL) with Jak-STAT signaling pathway in B-ALL -target gene hsa-mir-181a "Leukemia, Myelogenous, Chronic, BCR-ABL Positive" 28103766 inhibition of miR-181a using a microRNA sponge inhibitor resulted in decreased transcription of SOX2 and SALL4 -target gene hsa-mir-145 "Carcinoma, Hepatocellular" 28104805 MicroRNA-145 Modulates N6-Methyladenosine Levels by Targeting the 3'-Untranslated mRNA Region of the N6-Methyladenosine Binding YTH Domain Family 2 Protein. -target gene hsa-mir-150 Lung Neoplasms 28108217 CDK3 is a major target of miR-150 in cell proliferation and anti-cancer effect. -target gene hsa-mir-543 Osteosarcoma 28108312 CTGF promotes osteosarcoma angiogenesis by regulating miR-543/angiopoietin 2 signaling. -target gene hsa-mir-125b Melanoma 28108732 FAK regulates E-cadherin expression via p-SrcY416/p-ERK1/2/p-Stat3Y705 and PPAR¦Ã/miR-125b/Stat3 signaling pathway in B16F10 melanoma cells. -target gene hsa-mir-143 "Carcinoma, Prostate" 28109198 miR-143 Induces the Apoptosis of Prostate Cancer LNCap Cells by Suppressing Bcl-2 Expression. -target gene hsa-mir-214 Bone Disease [unspecific] 28109866 "miR-214 suppresses osteogenesis by targeting BIRC7, providing a possible therapeutic target for bone degenerative diseases" -target gene hsa-mir-150 Atherosclerosis 28110404 MicroRNA-150 targets ELK1 and modulates the apoptosis induced by ox-LDL in endothelial cells. -target gene hsa-mir-144 "Carcinoma, Gastric" 28111340 MicroRNA-144-3p suppresses gastric cancer progression by inhibiting epithelial-to-mesenchymal transition through targeting PBX3. -target gene hsa-mir-191a Inflammatory Bowel Diseases 28111380 Baicalin Protects against TNF-¦Á-Induced Injury by Down-Regulating miR-191a That Targets the Tight Junction Protein ZO-1 in IEC-6 Cells. -target gene hsa-mir-520c "Carcinoma, Breast" 28112380 miR520c blocks EMT progression of human breast cancer cells by repressing STAT3. -target gene hsa-mir-22 Heart Failure 28112401 MicroRNA-22 regulates inflammation and angiogenesis via targeting VE-cadherin. -target gene hsa-mir-206 Vascular Hypertrophy 28114137 MiR-206 affected the process of cardiomyocytes hypertrophy by regulating histone deacetylase 4 (HDAC4) -target gene hsa-mir-939 Coronary Artery Disease 28115160 MicroRNA-939 governs vascular integrity and angiogenesis through targeting ¦Ã-catenin in endothelial cells. -target gene hsa-mir-141 "Carcinoma, Gastric" 28115163 Lnc-ATB contributes to gastric cancer growth through a MiR-141-3p/TGF¦Â2 feedback loop. -target gene hsa-mir-379 "Carcinoma, Lung, Non-Small-Cell" 28117895 Suppression of EIF4G2 by miR-379 potentiates the cisplatin chemosensitivity in nonsmall cell lung cancer cells. -target gene hsa-mir-518 "Squamous Cell Carcinoma, Esophageal" 28119087 miR-518 inhibited the proliferation and invasion of esophageal squamous cell carcinoma (ESCC) cells possibly by targeting RAP1B -target gene hsa-mir-145 "Adenocarcinoma, Lung" 28120164 MiRNA-145 suppresses lung adenocarcinoma cell invasion and migration by targeting N-cadherin. -target gene hsa-mir-542 "Carcinoma, Breast" 28121348 miR-542-3p targets sphingosine-1-phosphate receptor 1 and regulates cell proliferation and invasion of breast cancer cells. -target gene hsa-mir-590 "Carcinoma, Breast" 28121351 MicroRNA miR-590-5p inhibits breast cancer cell stemness and metastasis by targeting SOX2. -target gene hsa-mir-1307 "Carcinoma, Prostate" 28122308 miR-1307 promotes the proliferation of prostate cancer by targeting FOXO3A. -target gene hsa-mir-125b "Carcinoma, Thyroid, Anaplastic" 28122310 MiR-125b inhibits anaplastic thyroid cancer cell migration and invasion by targeting PIK3CD. -target gene hsa-mir-182 "Carcinoma, Thyroid, Medullary" 28122586 MiR-182 promotes cancer invasion by linking RET oncogene activated NF-¦ÊB to loss of the HES1/Notch1 regulatory circuit. -target gene hsa-let-7a Vascular Hypertrophy 28123343 Let-7a Is an Antihypertrophic Regulator in the Heart via Targeting Calmodulin. -target gene hsa-mir-18a Glioblastoma 28123848 The malignancy of miR-18a in human glioblastoma via directly targeting CBX7. -target gene hsa-mir-34c Neoplasms [unspecific] 28125315 miRNA-34c inhibits myoblasts proliferation by targeting YY1. -target gene hsa-mir-199a "Carcinoma, Breast" 28126676 MiR-199a-3p enhances breast cancer cell sensitivity to cisplatin by downregulating TFAM (TFAM). -target gene hsa-mir-26a Neoplasms [unspecific] 28126920 Sustained expression of miR-26a promotes chromosomal instability and tumorigenesis through regulation of CHFR. -target gene hsa-mir-9 "Carcinoma, Gastric" 28127811 MicroRNA-9 inhibits the gastric cancer cell proliferation by targeting TNFAIP8. -target gene hsa-mir-187 "Carcinoma, Cervical" 28128400 miR-187 induces apoptosis of SiHa cervical carcinoma cells by downregulating Bcl-2. -target gene hsa-mir-146 Breast Neoplasms 28128741 miR-146a and miR-146-5p silencing BRCA1 may trigger formation of triple-negative and basal-like sporadic BC cases -target gene hsa-mir-92a Alzheimer Disease 28129110 "the AD-like tau accumulation induces anxiety through disrupting miR92a-vGAT-GABA signaling, which reveals molecular mechanisms underlying the anxiety behavior in AD patients and potentially leads to the development of new therapeutics for tauopathies" -target gene hsa-mir-21 Immune System Disease [unspecific] 28129531 MicroRNA-21 contributes to suppress cytokines production by targeting TLR28 in teleost fish. -target gene hsa-mir-650 Rheumatoid Arthritis 28129626 "MiR-650 inhibits proliferation, migration and invasion of rheumatoid arthritis synovial fibroblasts by targeting AKT2." -target gene hsa-mir-34a "Carcinoma, Hepatocellular" 28129650 MicroRNA-34a regulates liver regeneration and the development of liver cancer in rats by targeting Notch signaling pathway. -target gene hsa-mir-365 Heart Failure 28130111 MicroRNA-365 accelerates cardiac hypertrophy by inhibiting autophagy via the modulation of Skp2 expression. -target gene hsa-mir-18a Lung Fibrosis 28131417 miR-18a-5p Inhibits Sub-pleural Pulmonary Fibrosis by Targeting TGF-¦Â Receptor II. -target gene hsa-mir-146a Influenza 28131813 MicroRNA-146a induction during influenza H3N2 virus infection targets and regulates TRAF6 levels in human nasal epithelial cells (hNECs). -target gene hsa-mir-141 Hepatitis B Virus Infection 28135713 MicroRNA-141 Targets Sirt1 and Inhibits Autophagy to Reduce HBV Replication. -target gene hsa-mir-214 "Carcinoma, Cervical" 28137590 miR-214 down-regulates ARL2 and suppresses growth and invasion of cervical cancer cells. -target gene hsa-mir-21 "Squamous Cell Carcinoma, Head and Neck" 28138036 Suppression of the Growth and Invasion of Human Head and Neck Squamous Cell Carcinomas via Regulating STAT3 Signaling and the miR-21/¦Â-catenin Axis with HJC0152. -target gene hsa-mir-410 Osteosarcoma 28138700 MicroRNA-410 regulates autophagy-related gene ATG16L1 expression and enhances chemosensitivity via autophagy inhibition in osteosarcoma. -target gene hsa-mir-101 "Carcinoma, Renal Cell, Clear-Cell" 28138701 Hypoxia-induced hsa-miR-101 promotes glycolysis by targeting TIGAR mRNA in clear cell renal cell carcinoma. -target gene hsa-mir-155 "Carcinoma, Pancreatic" 28152544 "Exosomes confer chemoresistance to pancreatic cancer cells by promoting ROS detoxification and miR-155-mediated suppression of key gemcitabine-metabolising enzyme, DCK." -target gene hsa-mir-138 Leukemia 28153721 MiR-138 indirectly regulates the MDR1 promoter by NF-¦ÊB/p65 silencing. -target gene hsa-mir-1271 "Carcinoma, Prostate" 28153722 Inhibition of DIXDC1 by microRNA-1271 suppresses the proliferation and invasion of prostate cancer cells. -target gene hsa-mir-34a "Leukemia, Myeloid, Chronic" 28157629 The epigenetically-regulated miR-34a targeting c-SRC suppresses RAF/MEK/ERK signaling pathway in K-562 cells. -target gene hsa-mir-1 Breast Neoplasms 28159933 Tumor suppressor miR-1 inhibits tumor growth and metastasis by simultaneously targeting multiple genes. -target gene hsa-mir-495 "Carcinoma, Gastric" 28159956 MicroRNA-495 Inhibits Gastric Cancer Cell Migration and Invasion Possibly via Targeting High Mobility Group AT-Hook 2 (HMGA2). -target gene hsa-mir-320a Glioma 28160566 "miR-320a functions as a suppressor for gliomas by targeting SND1 and ¦Â-catenin, and predicts the prognosis of patients." -target gene hsa-mir-130b "Carcinoma, Breast" 28163094 miR-130b-3p inhibits cell invasion and migration by targeting the Notch ligand Delta-like 1 in breast carcinoma. -target gene hsa-mir-29b Cardiovascular Diseases [unspecific] 28164126 The Involvement of miR-29b-3p in Arterial Calcification by Targeting Matrix Metalloproteinase-2. -target gene hsa-mir-15b "Squamous Cell Carcinoma, Skin or Unspecific" 28165568 MicroRNA15b regulates apoptosis of cutaneous squamous cell carcinoma SCL-1 cell line: a mechanism study. -target gene hsa-mir-212 "Carcinoma, Cervical" 28165569 Effect of miR-212 targeting TCF7L2 on the proliferation and metastasis of cervical cancer. -target gene hsa-mir-599 "Carcinoma, Lung, Non-Small-Cell" 28167280 The miR-599 promotes non-small cell lung cancer cell invasion via SATB2. -target gene hsa-mir-29c Gastric Neoplasms 28173777 microRNA-29c inhibits cell proliferation by targeting NASP in human gastric cancer. -target gene hsa-mir-224 "Carcinoma, Gastric" 28173803 "Hypoxia-inducible microRNA-224 promotes the cell growth, migration and invasion by directly targeting RASSF8 in gastric cancer." -target gene hsa-mir-143 "Squamous Cell Carcinoma, Oral" 28174335 "MicroRNA-143 suppresses oral squamous cell carcinoma cell growth, invasion and glucose metabolism through targeting hexokinase 2." -target gene hsa-mir-181 Osteoarthritis 28177757 MicroRNA-181 inhibits proliferation and promotes apoptosis of chondrocytes in osteoarthritis by targeting PTEN. -target gene hsa-mir-361 Glioma 28184914 MicroRNA-361-5p inhibits epithelial-to-mesenchymal transition of glioma cells through targeting Twist1. -target gene hsa-mir-30d "Squamous Cell Carcinoma, Esophageal" 28184915 MicroRNA-30d inhibits the migration and invasion of human esophageal squamous cell carcinoma cells via the post?transcriptional regulation of enhancer of zeste homolog?2. -target gene hsa-mir-922 "Carcinoma, Hepatocellular" 28184924 miR-922 regulates CYLD expression and promotes the cell proliferation of human hepatocellular carcinoma. -target gene hsa-mir-217 "Carcinoma, Hepatocellular" 28184926 "miR-217 suppresses proliferation, migration, and invasion promoting apoptosis via targeting MTDH in hepatocellular carcinoma." -target gene hsa-mir-520c Glioma 28184932 MicroRNA-520c inhibits glioma cell migration and invasion by the suppression of transforming growth factor-¦Â receptor type?2. -target gene hsa-mir-93 Bone Disease [unspecific] 28186136 FOXO1-suppressed miR-424 regulates the proliferation and osteogenic differentiation of MSCs by targeting FGF2 under oxidative stress. -target gene hsa-mir-28 "Lymphoma, Hodgkin" 28188132 miR-28 regulates the germinal center reaction and blocks tumor growth in preclinical models of non-Hodgkin lymphoma. -target gene hsa-mir-125a "Carcinoma, Breast" 28188287 A-to-I RNA Editing Up-regulates Human Dihydrofolate Reductase in Breast Cancer. -target gene hsa-mir-25 "Carcinoma, Breast" 28188287 A-to-I RNA Editing Up-regulates Human Dihydrofolate Reductase in Breast Cancer. -target gene hsa-mir-675 "Carcinoma, Colon" 28189050 "H19 Overexpression Induces Resistance to 1,25(OH)2D3 by Targeting VDR Through miR-675-5p in Colon Cancer Cells." -target gene hsa-mir-29a Diabetic Retinopathy 28189547 Role of microRNA-29a in the development of diabetic retinopathy by targeting AGT gene in a rat model. -target gene hsa-mir-24 Osteosarcoma 28189676 miR-24 represses metastasis of human osteosarcoma cells by targeting Ack1 via AKT/MMPs pathway. -target gene hsa-mir-30b "Carcinoma, Esophageal" 28189678 "miR-30b inhibits cancer cell growth, migration, and invasion by targeting homeobox A1 in esophageal cancer." -target gene hsa-mir-218 "Carcinoma, Lung" 28192397 Downregulation of miR-218 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer by targeting Slug/ZEB2 signaling. -target gene hsa-mir-143 "Adenocarcinoma, Pancreatic Ductal" 28194669 MiR-143 Targeting TAK1 Attenuates Pancreatic Ductal Adenocarcinoma Progression via MAPK and NF-¦ÊB Pathway In Vitro. -target gene hsa-mir-451 "Carcinoma, Pancreatic" 28197410 MiR-451 Promotes Cell Proliferation and Metastasis in Pancreatic Cancer through Targeting CAB39. -target gene hsa-mir-133a Ischemia-Reperfusion Injury 28198596 Propofol protects against hepatic ischemia/reperfusion injury via miR-133a-5p regulating the expression of MAPK6. -target gene hsa-mir-205 Lung Neoplasms 28199217 MicroRNA-205 targets SMAD4 in non-small cell lung cancer and promotes lung cancer cell growth in vitro and in vivo. -target gene hsa-mir-146a "Carcinoma, Lung, Non-Small-Cell" 28202053 Up-regulation of miR-146a increases the sensitivity of non-small cell lung cancer to DDP by downregulating cyclin J. -target gene hsa-mir-146a Stroke 28202285 Decreased miR-146a expression in acute ischemic stroke directly targets the Fbxl10 mRNA and is involved in modulating apoptosis. -target gene hsa-mir-101 Alzheimer Disease 28202389 Targeting the HDAC2/HNF-4A/miR-101b/AMPK Pathway Rescues Tauopathy and Dendritic Abnormalities in Alzheimer's Disease. -target gene hsa-mir-520f Neoplasms [unspecific] 28209612 miRNA-520f Reverses Epithelial-to-Mesenchymal Transition by Targeting ADAM9 and TGFBR2. -target gene hsa-mir-92a "Carcinoma, Ovarian" 28209618 The STAT3-miRNA-92-Wnt Signaling Pathway Regulates Spheroid Formation and Malignant Progression in Ovarian Cancer. -target gene hsa-mir-718 Sepsis 28209713 miR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN). -target gene hsa-mir-124 "Squamous Cell Carcinoma, Head and Neck" 28212569 MiR-124 acts as a tumor suppressor by inhibiting the expression of sphingosine kinase 1 and its downstream signaling in head and neck squamous cell carcinoma. -target gene hsa-mir-216a "Carcinoma, Colon" 28213952 Down-regulation of KIAA1199/CEMIP by miR-216a suppresses tumor invasion and metastasis in colorectal cancer. -target gene hsa-mir-155 Osteosarcoma 28214207 MicroRNA-155 targets MAP3K10 and regulates osteosarcoma cell growth. -target gene hsa-mir-15a "Aortic Aneurysm, Abdominal" 28214350 Upregulation of MicroRNA-15a Contributes to Pathogenesis of Abdominal Aortic Aneurysm (AAA) by Modulating the Expression of Cyclin-Dependent Kinase Inhibitor 2B (CDKN2B). -target gene hsa-mir-183 Pain 28214854 MicroRNA-183 Suppresses Neuropathic Pain and Expression of AMPA Receptors by Targeting mTOR/VEGF Signaling Pathway. -target gene hsa-mir-26a "Adenocarcinoma, Lung" 28214878 MiRNA-26a Contributes to the Acquisition of Malignant Behaviors of Doctaxel-Resistant Lung Adenocarcinoma Cells through Targeting EZH2. -target gene hsa-mir-32 Mycobacterium tuberculosis Infection 28215633 TLR-4/miRNA-32-5p/FSTL1 signaling regulates mycobacterial survival and inflammatory responses in Mycobacterium tuberculosis-infected macrophages. -target gene hsa-mir-153 Glioblastoma 28218035 MicroRNA-153 regulates glutamine metabolism in glioblastoma through targeting glutaminase. -target gene hsa-mir-139 Alzheimer Disease 28218780 MicroRNA-139 modulates Alzheimer's-associated pathogenesis in SAMP8 mice by targeting cannabinoid receptor type 2. -target gene hsa-mir-218 "Carcinoma, Bladder" 28222430 MicroRNA-218 Increases the Sensitivity of Bladder Cancer to Cisplatin by Targeting Glut1. -target gene hsa-mir-29b "Carcinoma, Endometrial" 28222438 MicroRNA-29b Inhibits Angiogenesis by Targeting VEGFA through the MAPK/ERK and PI3K/Akt Signaling Pathways in Endometrial Carcinoma. -target gene hsa-mir-29a Breast Neoplasms 28222663 miR-29a suppresses MCF-7 cell growth by downregulating tumor necrosis factor receptor 1. -target gene hsa-mir-181 "Carcinoma, Breast" 28224609 miR-181 elevates Akt signaling by co-targeting PHLPP2 and INPP4B phosphatases in luminal breast cancer. -target gene hsa-mir-216a Melanoma 28225180 microRNA-216b inhibits cell proliferation and migration in human melanoma by targeting FOXM1 in vitro and in vivo. -target gene hsa-mir-15b Multiple Sclerosis 28228555 MicroRNA-15b Suppresses Th17 Differentiation and Is Associated with Pathogenesis of Multiple Sclerosis by Targeting O-GlcNAc Transferase. -target gene hsa-mir-144 "Carcinoma, Hepatocellular" 28229969 "MicroRNA-144 inhibits hepatocellular carcinoma cell proliferation, invasion and migration by targeting ZFX." -target gene hsa-mir-21 Diabetes Mellitus 28230206 MiRNA-21 mediates the antiangiogenic activity of metformin through targeting PTEN and SMAD7 expression and PI3K/AKT pathway. -target gene hsa-mir-302b "Carcinoma, Lung" 28231299 miR-34a-5p/miR-34c-5p/miR-302b-3p-LEF1-CCND1/WNT2/MYC axis may be a crucial mechanism in inhibition of lung cancer metastasis by curcumin -target gene hsa-mir-34a "Carcinoma, Lung" 28231299 miR-34a-5p/miR-34c-5p/miR-302b-3p-LEF1-CCND1/WNT5/MYC axis may be a crucial mechanism in inhibition of lung cancer metastasis by curcumin -target gene hsa-mir-34c "Carcinoma, Lung" 28231299 miR-34a-5p/miR-34c-5p/miR-302b-3p-LEF1-CCND1/WNT6/MYC axis may be a crucial mechanism in inhibition of lung cancer metastasis by curcumin -target gene hsa-mir-22 "Carcinoma, Prostate" 28231399 MTA1-activated Epi-microRNA-22 regulates E-cadherin and prostate cancer invasiveness. -target gene hsa-mir-543 "Carcinoma, Cervical" 28231728 MicroRNA-543 acts as a prognostic marker and promotes the cell proliferation in cervical cancer by BRCA1-interacting protein 1. -target gene hsa-mir-122 "Carcinoma, Renal Cell" 28231730 MiR-122 promotes renal cancer cell proliferation by targeting Sprouty2. -target gene hsa-mir-221 Liver Injury 28232457 Dicer-dependent production of microRNA221 in hepatocytes inhibits p27 and is required for liver regeneration in mice. -target gene hsa-let-7 "Carcinoma, Lung, Non-Small-Cell" 28235063 Disturbance of the let-7/LIN28 double-negative feedback loop is associated with radio- and chemo-resistance in non-small cell lung cancer. -target gene hsa-mir-106b Acute Myocardial Infarction 28235791 High-throughput screening identifies microRNAs that target Nox2 and improve function after acute myocardial infarction. -target gene hsa-mir-148b Acute Myocardial Infarction 28235791 High-throughput screening identifies microRNAs that target Nox2 and improve function after acute myocardial infarction. -target gene hsa-mir-204 Acute Myocardial Infarction 28235791 High-throughput screening identifies microRNAs that target Nox2 and improve function after acute myocardial infarction. -target gene hsa-mir-181b Aortic Valve Disease 28236165 Mechanosensitive microRNA-181b Regulates Aortic Valve Endothelial Matrix Degradation by Targeting TIMP3. -target gene hsa-mir-26a "Carcinoma, Lung" 28237093 MiR-26a enhances invasive capacity by suppressing GSK3¦Â in human lung cancer cells. -target gene hsa-mir-15b "Carcinoma, Hepatocellular" 28239814 microRNA15b induced SMCC7721 apoptosis via down-regulation of XIAP. -target gene hsa-mir-137 "Carcinoma, Lung, Non-Small-Cell" 28239819 MiR-137 and its target TGFA modulate cell growth and tumorigenesis of non-small cell lung cancer. -target gene hsa-mir-29c "Adenocarcinoma, Lung" 28241836 MicroRNA-29c functions as a tumor suppressor by targeting VEGFA in lung adenocarcinoma. -target gene hsa-mir-520e "Carcinoma, Lung, Non-Small-Cell" 28242196 MicroRNA-520e suppresses non-small-cell lung cancer cell growth by targeting Zbtb7a-mediated Wnt signaling pathway. -target gene hsa-mir-124 Glioblastoma 28242198 miR-124 suppresses glioblastoma growth and potentiates chemosensitivity by inhibiting AURKA. -target gene hsa-mir-130 Obesity 28242765 APCDD1 positively regulates adipogenic differentiation and that its down-regulation by miR-130 during DIO may contribute to impaired adipogenic differentiation and obesity-related metabolic disease -target gene hsa-mir-98 "Carcinoma, Hepatocellular" 28244848 MicroRNA-98-5p Inhibits Cell Proliferation and Induces Cell Apoptosis in Hepatocellular Carcinoma via Targeting IGF2BP1. -target gene hsa-mir-543 "Carcinoma, Prostate" 28245474 MiR-543 Promotes Proliferation and Epithelial-Mesenchymal Transition in Prostate Cancer via Targeting RKIP. -target gene hsa-mir-155 Wound Healing 28247149 miR-155 promotes cutaneous wound healing through enhanced keratinocytes migration by MMP-2. -target gene hsa-mir-20b Viral Myocarditis 28247213 MicroRNA-20b suppresses the expression of ZFP-148 in viral myocarditis. -target gene hsa-mir-98 Endomyocardial Fibrosis 28251559 MicroRNA-98 inhibits TGF-¦Â1-induced differentiation and collagen production of cardiac fibroblasts by targeting TGFBR1. -target gene hsa-mir-15b Coronary Artery Disease 28254819 MiR-15b-5p Regulates Collateral Artery Formation by Targeting AKT3 (Protein Kinase B-3). -target gene hsa-mir-19a "Carcinoma, Colon" 28257633 miR-19a promotes colorectal cancer proliferation and migration by targeting TIA1. -target gene hsa-mir-133a Atherosclerosis 28257760 Induction of MiR133a expression by IL-19 targets LDLRAP1 and reduces oxLDL uptake in VSMC. -target gene hsa-mir-185 Keloid 28259900 MicroRNA?185 regulates transforming growth factor?¦Â1 and collagen?1 in hypertrophic scar fibroblasts. -target gene hsa-mir-7 "Carcinoma, Pancreatic" 28259961 MicroRNA-7 functions as a tumor-suppressor gene by regulating ILF2 in pancreatic carcinoma. -target gene hsa-mir-30a "Carcinoma, Lung, Non-Small-Cell" 28259977 miR-30a radiosensitizes non-small cell lung cancer by targeting ATF1 that is involved in the phosphorylation of ATM. -target gene hsa-mir-365 Glioma 28260020 "MicroRNA-365 inhibits proliferation, migration and invasion of glioma by targeting PIK3R3." -target gene hsa-mir-134 "Carcinoma, Gastric" 28260021 MicroRNA-134 suppresses cell proliferation in gastric cancer cells via targeting of GOLPH3. -target gene hsa-mir-125b "Carcinoma, Nasopharyngeal" 28260044 microRNA-125b reverses the multidrug resistance of nasopharyngeal carcinoma cells via targeting of Bcl-2. -target gene hsa-mir-126 "Carcinoma, Gastric" 28260063 ADAM9 functions as a promoter of gastric cancer growth which is negatively and post-transcriptionally regulated by miR-126. -target gene hsa-mir-125b Osteoarthritis 28260078 Upregulation of microRNA-125b-5p is involved in the pathogenesis of osteoarthritis by downregulating SYVN1. -target gene hsa-mir-1271 "Carcinoma, Lung, Non-Small-Cell" 28260088 Foxk2 inhibits non-small cell lung cancer epithelial-mesenchymal transition and proliferation through the repression of different key target genes. -target gene hsa-mir-92a Osteosarcoma 28260104 miR-92a promotes tumor growth of osteosarcoma by targeting PTEN/AKT signaling pathway. -target gene hsa-mir-21 Osteosarcoma 28260111 miR-21-5p may be associated with metastasis via target genes -target gene hsa-mir-9 "Leukemia, Myeloid, Chronic" 28260112 miR-9 regulates the multidrug resistance of chronic myelogenous leukemia by targeting ABCB1. -target gene hsa-mir-199a "Carcinoma, Hepatocellular" 28261837 MiR-199a-5p suppresses tumorigenesis by targeting clathrin heavy chain in hepatocellular carcinoma. -target gene hsa-mir-23b "Carcinoma, Hepatocellular" 28262617 microRNA-23b suppresses epithelial-mesenchymal transition (EMT) and metastasis in hepatocellular carcinoma via targeting Pyk2. -target gene hsa-mir-377 "Squamous Cell Carcinoma, Oral" 28267394 Downregulation of miR-377 Promotes Oral Squamous Cell Carcinoma Growth and Migration by Targeting HDAC9. -target gene hsa-mir-1 "Carcinoma, Bladder" 28268231 "MiR-1-3p Suppresses the Proliferation, Invasion and Migration of Bladder Cancer Cells by Up-Regulating SFRP1 Expression." -target gene hsa-mir-31 "Carcinoma, Hepatocellular" 28269758 MicroRNA31-NDRG3 regulation axes are essential for hepatocellular carcinoma survival and drug resistance. -target gene hsa-mir-124 Glioma 28272711 Down-regulation of miR-124 target protein SCP-1 inhibits neuroglioma cell migration. -target gene hsa-mir-875 "Carcinoma, Prostate" 28274892 miR-875-5p counteracts epithelial-to-mesenchymal transition and enhances radiation response in prostate cancer through repression of the EGFR-ZEB1 axis. -target gene hsa-mir-34a Osteosarcoma 28275089 "The miR-34a/STMN1/¦ÂIII-tubulin axis maintains the microtubule cytoskeleton in osteosarcoma, and combining miR-34a with microtubule inhibitors can be investigated as a novel therapeutic strategy" -target gene hsa-mir-142 Inflammation 28275790 MiR-142-3p inhibits lipopolysaccharide-induced inflammatory response in human periodontal ligament cells through targeting IRAK1. -target gene hsa-mir-422a Glioma 28277190 miR-422a Inhibits Glioma Proliferation and Invasion by Targeting IGF1 and IGF1R. -target gene hsa-mir-202 "Squamous Cell Carcinoma, Esophageal" 28277193 miR-202 Promotes Cell Apoptosis in Esophageal Squamous Cell Carcinoma by Targeting HSF2. -target gene hsa-mir-146a Graves Disease 28278511 Mechanism of MicroRNA-146a/Notch2 Signaling Regulating IL-6 in Graves Ophthalmopathy. -target gene hsa-mir-181a Osteoarthritis 28280258 miR-181a Modulates Chondrocyte Apoptosis by Targeting Glycerol-3-Phosphate Dehydrogenase 1-Like Protein (GPD1L) in Osteoarthritis. -target gene hsa-mir-21 "Diabetes Mellitus, Type 1" 28280903 MicroRNA 21 targets BCL2 mRNA to increase apoptosis in rat and human beta cells. -target gene hsa-mir-200a Pancreatic Neoplasms 28281184 TGF-¦Â1-miR-200a-PTEN induces epithelial-mesenchymal transition and fibrosis of pancreatic stellate cells. -target gene hsa-mir-93 Neuropathic Pain 28284149 MicroRNA-93 alleviates neuropathic pain through targeting signal transducer and activator of transcription 3. -target gene hsa-mir-181d Glioblastoma 28286260 miR-181d/MALT1 regulatory axis attenuates mesenchymal phenotype through NF-¦ÊB pathways in glioblastoma. -target gene hsa-mir-133a "Carcinoma, Pancreatic" 28286270 "USP39, a direct target of microRNA-133a, promotes progression of pancreatic cancer via the AKT pathway." -target gene hsa-mir-181a "Carcinoma, Breast" 28288641 "SOX2 regulates multiple malignant processes of breast cancer development through the SOX2/miR-181a-5p, miR-30e-5p/TUSC3 axis." -target gene hsa-mir-30e "Carcinoma, Breast" 28288641 "SOX2 regulates multiple malignant processes of breast cancer development through the SOX2/miR-181a-5p, miR-30e-5p/TUSC3 axis." -target gene hsa-mir-146a Sepsis 28288804 MiR-146a potentially promotes IVIg-mediated inhibition of TLR4 signaling in LPS-activated human monocytes. -target gene hsa-mir-214 "Carcinoma, Oral" 28290615 MiR-214 regulates oral cancer KB cell apoptosis through targeting RASSF5. -target gene hsa-mir-30a Idiopathic Pulmonary Fibrosis 28294974 miR-30a as Potential Therapeutics by Targeting TET1 through Regulation of Drp-1 Promoter Hydroxymethylation in Idiopathic Pulmonary Fibrosis. -target gene hsa-mir-182 "Leukemia, Promyelocytic, Acute" 28298075 Inducing cell proliferative prevention in human acute promyelocytic leukemia by miR-182 inhibition through modulation of CASP9 expression. -target gene hsa-mir-146a Diabetes Mellitus 28301595 miR-146a regulates glucose induced upregulation of inflammatory cytokines extracellular matrix proteins in the retina and kidney in diabetes. -target gene hsa-mir-495 "Carcinoma, Lung, Small-Cell" 28302484 TSPAN12 promotes chemoresistance and proliferation of SCLC under the regulation of miR-495. -target gene hsa-mir-146a Osteoarthritis 28314786 Effects of microRNA-146a on the proliferation and apoptosis of human osteoarthritis chondrocytes by targeting TRAF6 through the NF-¦ÊB signalling pathway. -target gene hsa-mir-519 "Carcinoma, Nasopharyngeal" 28315691 miR-519 suppresses nasopharyngeal carcinoma cell proliferation by targeting oncogene URG4/URGCP. -target gene hsa-mir-186 "Carcinoma, Lung, Non-Small-Cell" 28317368 MiR-186 Inhibited Migration of NSCLC via Targeting cdc42 and Effecting EMT Process. -target gene hsa-mir-218 "Carcinoma, Gastric" 28323002 miR-218 inhibited tumor angiogenesis by targeting ROBO1 in gastric cancer. -target gene hsa-mir-302b Glioma 28323865 The microRNA-302b-inhibited insulin-like growth factor-binding protein 2 signaling pathway induces glioma cell apoptosis by targeting nuclear factor IA. -target gene hsa-mir-181b Cardiovascular Diseases [unspecific] 28323879 miR-181b regulates vascular stiffness age dependently in part by regulating TGF-¦Â signaling. -target gene hsa-mir-199 "Carcinoma, Bladder" 28324890 Regulation of ITGA3 by the dual-stranded microRNA-199 family as a potential prognostic marker in bladder cancer. -target gene hsa-mir-27a Gastric Neoplasms 28327189 MicroRNA-27a contributes to the malignant behavior of gastric cancer cells by directly targeting PH domain and leucine-rich repeat protein phosphatase 2. -target gene hsa-mir-3908 "Carcinoma, Breast" 28327197 Lipid raft-mediated miR-3908 inhibition of migration of breast cancer cell line MCF-7 by regulating the interactions between AdipoR1 and Flotillin-1. -target gene hsa-mir-488 Melanoma 28328082 MicroRNA-488-3p sensitizes malignant melanoma cells to cisplatin by targeting PRKDC. -target gene hsa-mir-9 Atherosclerosis 28334721 MicroRNA-9 Inhibits NLRP3 Inflammasome Activation in Human Atherosclerosis Inflammation Cell Models through the JAK1/STAT Signaling Pathway. -target gene hsa-mir-122 Gastric Neoplasms 28337380 MicroRNA-122 inhibits proliferation and invasion in gastric cancer by targeting CREB1. -target gene hsa-mir-373 "Squamous Cell Carcinoma, Tongue" 28337453 miR-373-3p Targets DKK1 to Promote EMT-Induced Metastasis via the Wnt/¦Â-Catenin Pathway in Tongue Squamous Cell Carcinoma. -target gene hsa-mir-370 Cerebral Aneurysm 28338184 MicroRNA-370-3p inhibits human vascular smooth muscle cell proliferation via targeting KDR/AKT signaling pathway in cerebral aneurysm. -target gene hsa-mir-146a Lupus Nephritis 28338190 The role of miR-146a in modulating TRAF6-induced inflammation during lupus nephritis. -target gene hsa-mir-155 Neoplasms [unspecific] 28338203 "MiR-155 regulates oral squamous cell carcinoma Tca8113 cell proliferation, cycle, and apoptosis via regulating p27Kip1." -target gene hsa-mir-374b "Carcinoma, Colon" 28339062 p53/microRNA-374b/AKT1 regulates colorectal cancer cell apoptosis in response to DNA damage. -target gene hsa-mir-140 Osteosarcoma 28341864 MicroRNA-140-5p regulates osteosarcoma chemoresistance by targeting HMGN5 and autophagy. -target gene hsa-mir-206 Atherosclerosis 28342807 Myocardin inhibited the gap protein connexin 43 via promoted miR-206 to regulate vascular smooth muscle cell phenotypic switch. -target gene hsa-mir-29a "Carcinoma, Hepatocellular" 28342862 miR-29a suppresses growth and migration of hepatocellular carcinoma by regulating CLDN1. -target gene hsa-mir-448 Multiple Sclerosis 28342869 MicroRNA-448 promotes multiple sclerosis development through induction of Th17 response through targeting protein tyrosine phosphatase non-receptor type 2 (PTPN2). -target gene hsa-mir-373 Osteoarthritis 28343378 Adipose-Derived Stem Cells Suppress Inflammation Induced by IL-1¦Â through Down-Regulation of P2X7R Mediated by miR-373 in Chondrocytes of Osteoarthritis. -target gene hsa-mir-29c "Carcinoma, Lung" 28345453 Tumor suppressor miR-29c regulates radioresistance in lung cancer cells. -target gene hsa-mir-195 Colorectal Carcinoma 28345460 Coactivator-associated arginine methyltransferase 1 promotes cell growth and is targeted by microRNA-195-5p in human colorectal cancer. -target gene hsa-mir-590 "Carcinoma, Prostate" 28345464 MicroRNA-590-3p promotes cell proliferation and invasion by targeting inositol polyphosphate 4-phosphatase type II in human prostate cancer cells. -target gene hsa-mir-21 Colorectal Carcinoma 28347230 Inhibition of microRNA-21 via locked nucleic acid-anti-miR suppressed metastatic features of colorectal cancer cells through modulation of programmed cell death 4. -target gene hsa-mir-22 Colorectal Carcinoma 28347238 "The predicted target gene validation, function, and prognosis studies of miRNA-22 in colorectal cancer tissue." -target gene hsa-mir-34a Colorectal Carcinoma 28348487 miR-34a mediates oxaliplatin resistance of colorectal cancer cells by inhibiting macroautophagy via transforming growth factor-¦Â/Smad4 pathway. -target gene hsa-mir-200 "Carcinoma, Pancreatic" 28349057 Interleukin-9 Promotes Pancreatic Cancer Cells Proliferation and Migration via the miR-200a/Beta-Catenin Axis. -target gene hsa-mir-200a "Carcinoma, Pancreatic" 28349057 Interleukin-9 Promotes Pancreatic Cancer Cells Proliferation and Migration via the miR-200a/Beta-Catenin Axis. -target gene hsa-mir-145 "Carcinoma, Breast" 28349828 "Silencing of bach1 gene by small interfering RNA-mediation regulates invasive and expression level of miR-203, miR-145, matrix metalloproteinase-9, and CXCR4 receptor in MDA-MB-468 breast cancer cells." -target gene hsa-mir-203 "Carcinoma, Breast" 28349828 "Silencing of bach1 gene by small interfering RNA-mediation regulates invasive and expression level of miR-203, miR-145, matrix metalloproteinase-9, and CXCR4 receptor in MDA-MB-468 breast cancer cells." -target gene hsa-mir-590 "Carcinoma, Hepatocellular" 28349829 MiR-590-3p suppresses hepatocellular carcinoma growth by targeting TEAD1. -target gene hsa-mir-203 "Carcinoma, Lung, Non-Small-Cell" 28350100 Overexpression of miR-203 increases the sensitivity of NSCLC A549/H460 cell lines to cisplatin by targeting Dickkopf-1. -target gene hsa-mir-455 "Carcinoma, Prostate" 28350134 MicroRNA-455-3p functions as a tumor suppressor by targeting eIF4E in prostate cancer. -target gene hsa-mir-15b "Squamous Cell Carcinoma, Tongue" 28350138 miR-15b inhibits cancer-initiating cell phenotypes and chemoresistance of cisplatin by targeting TRIM14 in oral tongue squamous cell cancer. -target gene hsa-mir-613 Retinoblastoma 28351331 "MiR-613 suppresses retinoblastoma cell proliferation, invasion, and tumor formation by targeting E2F5." -target gene hsa-mir-145 Pituitary Adenoma 28352194 MicroRNA-145 inhibits the activation of the mTOR signaling pathway to suppress the proliferation and invasion of invasive pituitary adenoma cells by targeting AKT3 in vivo and in vitro. -target gene hsa-mir-302d "Carcinoma, Hepatocellular" 28352351 MicroRNA-302d downregulates TGFBR2 expression and promotes hepatocellular carcinoma growth and invasion. -target gene hsa-mir-24 Glioblastoma 28352781 SOX7 inhibits tumor progression of glioblastoma and is regulated by miRNA-24. -target gene hsa-mir-155 Biliary Atresia 28355202 MicroRNA-155 modulates bile duct inflammation by targeting the suppressor of cytokine signaling 1 in biliary atresia. -target gene hsa-mir-532 "Carcinoma, Gastric" 28356225 miR-532 promoted gastric cancer migration and invasion by targeting NKD1. -target gene hsa-mir-27 Adenovirus Infection 28356525 MicroRNA miR-27 Inhibits Adenovirus Infection by Suppressing the Expression of SNAP25 and TXN2. -target gene hsa-mir-27a Adenovirus Infection 28356525 MicroRNA miR-27 Inhibits Adenovirus Infection by Suppressing the Expression of SNAP25 and TXN2. -target gene hsa-mir-27b Adenovirus Infection 28356525 MicroRNA miR-27 Inhibits Adenovirus Infection by Suppressing the Expression of SNAP25 and TXN2. -target gene hsa-mir-103a "Aortic Aneurysm, Abdominal" 28357407 Role of MicroRNA-103a Targeting ADAM10 in Abdominal Aortic Aneurysm. -target gene hsa-mir-194 Melanoma 28358423 Circulating microRNA-194 regulates human melanoma cells via PI3K/AKT/FoxO3a and p53/p21 signaling pathway. -target gene hsa-mir-200 Glioma 28362995 Targeting effect of microRNA on CD133 and its impact analysis on proliferation and invasion of glioma cells. -target gene hsa-mir-200b Glioma 28362995 Targeting effect of microRNA on CD133 and its impact analysis on proliferation and invasion of glioma cells. -target gene hsa-mir-199a "Carcinoma, Lung" 28363780 miR-199a-5p and miR-495 target GRP78 within UPR pathway of lung cancer. -target gene hsa-mir-495 "Carcinoma, Lung" 28363780 miR-199a-5p and miR-495 target GRP78 within UPR pathway of lung cancer. -target gene hsa-mir-19a "Carcinoma, Lung" 28364280 Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer. -target gene hsa-mir-19b "Carcinoma, Lung" 28364280 Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer. -target gene hsa-mir-29b Breast Neoplasms 28365400 MiRNA-29b suppresses tumor growth through simultaneously inhibiting angiogenesis and tumorigenesis by targeting Akt3. -target gene hsa-mir-200a "Carcinoma, Hepatocellular" 28367241 MicroRNA-200a inhibits cell growth and metastasis by targeting Foxa2 in hepatocellular carcinoma. -target gene hsa-mir-126 Obesity 28367267 Obesity Downregulates MicroRNA-126 Inducing Capillary Rarefaction in Skeletal Muscle: Effects of Aerobic Exercise Training. -target gene hsa-mir-494 Spinal Cord Injuries 28368292 Long Coding RNA XIST Contributes to Neuronal Apoptosis through the Downregulation of AKT Phosphorylation and Is Negatively Regulated by miR-494 in Rat Spinal Cord Injury. -target gene hsa-mir-294 "Carcinoma, Bladder" 28371605 MicroRNA-294 Promotes Cellular Proliferation and Motility through the PI3K/AKT and JAK/STAT Pathways by Upregulation of NRAS in Bladder Cancer. -target gene hsa-mir-34 "Carcinoma, Prostate" 28373004 Natural killer cells suppress enzalutamide resistance and cell invasion in the castration resistant prostate cancer via targeting the androgen receptor splicing variant 7 (ARv7). -target gene hsa-mir-449 "Carcinoma, Prostate" 28373004 Natural killer cells suppress enzalutamide resistance and cell invasion in the castration resistant prostate cancer via targeting the androgen receptor splicing variant 7 (ARv7). -target gene hsa-mir-375 Colorectal Carcinoma 28374902 Impact of microRNA-375 and its target gene SMAD-7 polymorphism on susceptibility of colorectal cancer. -target gene hsa-mir-363 Rheumatoid Arthritis 28376277 Dendritic Cells from Rheumatoid Arthritis Patient Peripheral Blood Induce Th17 Cell Differentiation via miR-363/Integrin ¦Áv/TGF-¦Â Axis. -target gene hsa-let-7e "Carcinoma, Ovarian" 28376831 Let-7e sensitizes epithelial ovarian cancer to cisplatin through repressing DNA double strand break repair. -target gene hsa-mir-874 "Carcinoma, Pancreatic" 28377226 Aquaporin 3 facilitates tumor growth in pancreatic cancer by modulating mTOR signaling. -target gene hsa-mir-486 Aortic Valve Disease 28377507 miR-486 inhibits Smurf2 expression to augment the miR-204 down-regulation -target gene hsa-mir-20a "Carcinoma, Hepatocellular" 28378640 Bioinformatics prediction and experimental validation of microRNA-20a targeting Cyclin D1 in hepatocellular carcinoma. -target gene hsa-mir-125b "Carcinoma, Lung, Non-Small-Cell" 28378642 Targeting insulin-like growth factor-binding protein-3 by microRNA-125b promotes tumor invasion and poor outcomes in non-small-cell lung cancer. -target gene hsa-mir-144 Influenza 28380049 miR-144 attenuates the host response to influenza virus by targeting the TRAF6-IRF7 signaling axis. -target gene hsa-mir-181a Osteosarcoma 28381158 Triptolide inhibits the growth of osteosarcoma by regulating microRNA-181a via targeting PTEN gene in vivo and vitro. -target gene hsa-mir-181d "Carcinoma, Pancreatic" 28381166 Downregulation of microRNA-181d had suppressive effect on pancreatic cancer development through inverse regulation of KNAIN2. -target gene hsa-mir-146a Osteoarthritis 28383548 miR-146a facilitates osteoarthritis by regulating cartilage homeostasis via targeting Camk2d and Ppp3r2. -target gene hsa-mir-200b "Carcinoma, Hepatocellular" 28383782 The miR-200b-ZEB1 circuit regulates diverse stemness of human hepatocellular carcinoma. -target gene hsa-mir-138 "Carcinoma, Cervical" 28385388 MicroRNA-138 is a potential biomarker and tumor suppressor in human cervical carcinoma by reversely correlated with TCF3 gene. -target gene hsa-mir-137 Glioblastoma 28386374 MicroRNA-137 inhibits growth of glioblastoma through EGFR suppression. -target gene hsa-mir-370 "Carcinoma, Hepatocellular" 28387905 miRNA-370 acts as a tumor suppressor via the downregulation of PIM1 in hepatocellular carcinoma. -target gene hsa-mir-181a Glioblastoma 28389242 Upregulation of miR-181a suppresses the formation of glioblastoma stem cells by targeting the Notch2 oncogene and correlates with good prognosis in patients with glioblastoma multiforme. -target gene hsa-mir-125b Leukemia 28389358 MicroRNA-125b inhibits AML cells differentiation by directly targeting Fes. -target gene hsa-mir-135a "Carcinoma, Hepatocellular" 28389526 Regulation of UDP-Glucuronosyltransferases UGT2B4 and UGT2B7 by MicroRNAs in Liver Cancer Cells. -target gene hsa-mir-216b "Carcinoma, Hepatocellular" 28389526 Regulation of UDP-Glucuronosyltransferases UGT2B4 and UGT2B7 by MicroRNAs in Liver Cancer Cells. -target gene hsa-mir-3664 "Carcinoma, Hepatocellular" 28389526 Regulation of UDP-Glucuronosyltransferases UGT2B4 and UGT2B7 by MicroRNAs in Liver Cancer Cells. -target gene hsa-mir-410 "Carcinoma, Hepatocellular" 28389526 Regulation of UDP-Glucuronosyltransferases UGT2B4 and UGT2B7 by MicroRNAs in Liver Cancer Cells. -target gene hsa-mir-181d Glioblastoma 28389653 Identification of IGF-1-enhanced cytokine expressions targeted by miR-181d in glioblastomas via an integrative miRNA/mRNA regulatory network analysis. -target gene hsa-mir-21 Acute Cerebral Infarction 28389999 Effects of microRNA-21 on Nerve Cell Regeneration and Neural Function Recovery in Diabetes Mellitus Combined with Cerebral Infarction Rats by Targeting PDCD4. -target gene hsa-mir-661 Osteosarcoma 28391262 MicroRNA-661 Enhances TRAIL or STS Induced Osteosarcoma Cell Apoptosis by Modulating the Expression of Cytochrome c1. -target gene hsa-mir-143 "Carcinoma, Prostate" 28391351 Curcumin inhibits prostate cancer by targeting PGK1 in the FOXD3/miR-143 axis. -target gene hsa-mir-206 "Carcinoma, Breast" 28391353 WBP2 modulates G1/S transition in ER+?breast cancer cells and is a direct target of miR-206. -target gene hsa-mir-221 "Carcinoma, Lung, Non-Small-Cell" 28392366 miRNA-221 acts as an oncogenic role by directly targeting TIMP2 in non-small-cell lung carcinoma. -target gene hsa-mir-145 "Carcinoma, Breast" 28393176 miR-145 inhibits proliferation and migration of breast cancer cells by directly or indirectly regulating TGF-¦Â1 expression. -target gene hsa-mir-107 "Squamous Cell Carcinoma, Esophageal" 28393193 miR-107 functions as a tumor suppressor in human esophageal squamous cell carcinoma and targets Cdc42. -target gene hsa-mir-187 "Carcinoma, Lung, Non-Small-Cell" 28393200 MicroRNA-187 modulates epithelial-mesenchymal transition by targeting PTRF in non-small cell lung cancer. -target gene hsa-mir-539 "Carcinoma, Hepatocellular" 28393215 miR-539 inhibits FSCN1 expression and suppresses hepatocellular carcinoma migration and invasion. -target gene hsa-mir-124 Glioma 28393219 Inhibition of the Hedgehog signaling pathway suppresses cell proliferation by regulating the Gli2/miR-124/AURKA axis in human glioma cells. -target gene hsa-mir-27a "Carcinoma, Nasopharyngeal" 28393229 Dysregulated miR-27a-3p promotes nasopharyngeal carcinoma cell proliferation and migration by targeting Mapk10. -target gene hsa-mir-329 "Carcinoma, Cervical" 28393232 "MicroRNA-329-3p targets MAPK1 to suppress cell proliferation, migration and invasion in cervical cancer." -target gene hsa-mir-130a Neoplasms [unspecific] 28393235 Epigenetic silencing of miR-130a ameliorates hemangioma by targeting tissue factor pathway inhibitor?2 through FAK/PI3K/Rac1/mdm2 signaling. -target gene hsa-mir-10b Glioblastoma 28393237 "MicroRNA-10b mediates TGF-¦Â1-regulated glioblastoma proliferation, migration and epithelial-mesenchymal transition." -target gene hsa-mir-597 "Carcinoma, Breast" 28393251 "miR-597 inhibits breast cancer cell proliferation, migration and invasion through FOSL2." -target gene hsa-mir-4417 "Carcinoma, Hepatocellular" 28394882 miR-4417 Targets Tripartite Motif-Containing 35 (TRIM35) and Regulates Pyruvate Kinase Muscle 2 (PKM2) Phosphorylation to Promote Proliferation and Suppress Apoptosis in Hepatocellular Carcinoma Cells. -target gene hsa-mir-9 Breast Neoplasms 28397066 "MicroRNA-9 promotes the proliferation, migration, and invasion of breast cancer cells via down-regulating FOXO1." -target gene hsa-mir-150 Psoriasis 28399173 MiR-150 regulates human keratinocyte proliferation in hypoxic conditions through targeting HIF-1¦Á and VEGFA: Implications for psoriasis treatment. -target gene hsa-mir-34a "Carcinoma, Gastric" 28399871 IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis. -target gene hsa-mir-18a "Carcinoma, Hepatocellular" 28399983 microRNA-18a Promotes Cell Migration and Invasion Through Inhibiting Dicer l Expression in Hepatocellular Carcinoma In Vitro. -target gene hsa-mir-146a Neoplasms [unspecific] 28401709 The role of microRNA-93 regulating angiopoietin2 in the formation of malignant pleural effusion. -target gene hsa-mir-93 Neoplasms [unspecific] 28401709 The role of microRNA-93 regulating angiopoietin2 in the formation of malignant pleural effusion. -target gene hsa-mir-210 Cervical Neoplasms 28401751 Down-Regulation of MicroRNA-210 Confers Sensitivity towards 1'S-1'-Acetoxychavicol Acetate (ACA) in Cervical Cancer Cells by Targeting SMAD4. -target gene hsa-mir-200 "Carcinoma, Lung, Non-Small-Cell" 28405157 Decitabine reverses TGF-¦Â1-induced epithelial-mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axis. -target gene hsa-mir-30a "Carcinoma, Lung, Non-Small-Cell" 28405690 MicroRNA-30a-5p suppresses epithelial-mesenchymal transition by targeting profilin-2 in high invasive non-small cell lung cancer cell lines. -target gene hsa-mir-381 Osteosarcoma 28406476 "WISP-1 enhances VEGF-A expression and angiogenesis through the FAK/JNK/HIF-1¦Á signaling pathways, as well as via down-regulation of miR-381 expression" -target gene hsa-mir-137 Breast Neoplasms 28407692 MicroRNA-137 inhibits BMP7 to enhance the epithelial-mesenchymal transition of breast cancer cells. -target gene hsa-mir-18a "Adenocarcinoma, Colon" 28408657 Negative Regulation of Human Pregnane X Receptor by MicroRNA-18a-5p: Evidence for Suppression of MicroRNA-18a-5p Expression by Rifampin and Rilpivirine. -target gene hsa-mir-106b "Carcinoma, Hepatocellular" 28410209 MiR-106b inhibitors sensitize TRAIL-induced apoptosis in hepatocellular carcinoma through increase of death receptor 4. -target gene hsa-mir-21 Glioblastoma 28410224 Glioma stem cells-derived exosomes promote the angiogenic ability of endothelial cells through miR-21/VEGF signal. -target gene hsa-mir-302c "Carcinoma, Renal Cell" 28412750 microRNA-302c-3p inhibits renal cell carcinoma cell proliferation by targeting Grb2-associated binding 2 (Gab2). -target gene hsa-mir-98 "Carcinoma, Lung, Non-Small-Cell" 28415380 miR-98 inhibits expression of TWIST to prevent progression of non-small cell lung cancers. -target gene hsa-mir-330 "Carcinoma, Breast" 28419078 Targeting of CCBE1 by miR-330-3p in human breast cancer promotes metastasis. -target gene hsa-mir-193a "Carcinoma, Prostate" 28422308 Androgen receptor-regulated miRNA-193a-3p targets AJUBA to promote prostate cancer cell migration. -target gene hsa-mir-16 Myocardial Infarction 28423616 Suppression of microRNA-16 protects against acute myocardial infarction by reversing beta2-adrenergic receptor down-regulation in rats. -target gene hsa-mir-223 Pancreatic Neoplasms 28423622 HnRNPK/miR-223/FBXW7 feedback cascade promotes pancreatic cancer cell growth and invasion. -target gene hsa-mir-126 Atherosclerosis 28425867 MiR-126 activates the endothelial production of a chemokine CXCL12 via self-multiplying feedback loop to promote re-endothelialization and support lesion stability -target gene hsa-mir-299 Neoplasms [unspecific] 28426762 Human microRNA-299-3p decreases invasive behavior of cancer cells by downregulation of Oct4 expression and causes apoptosis. -target gene hsa-mir-142 "Carcinoma, Lung, Non-Small-Cell" 28427045 MiR-142-3p Overexpression Increases Chemo-Sensitivity of NSCLC by Inhibiting HMGB1-Mediated Autophagy. -target gene hsa-mir-494 Intervertebral Disc Degeneration 28427186 MicroRNA-494 promotes ECM degradation and apoptosis of degenerative human NP cells by directly targeting SOX9 -target gene hsa-mir-146b "Carcinoma, Thyroid, Follicular" 28427206 "miR-146a and miR-146b promote proliferation, migration and invasion of follicular thyroid carcinoma via inhibition of ST8SIA4." -target gene hsa-mir-205 Endometrial Neoplasms 28427207 miR-205 inhibits cell growth by targeting AKT-mTOR signaling in progesterone-resistant endometrial cancer Ishikawa cells. -target gene hsa-mir-218 "Carcinoma, Lung, Non-Small-Cell" 28429357 Inhibition of pulmonary carcinoma proliferation or metastasis of miR-218 via down-regulating CDCP1 expression. -target gene hsa-mir-148a Breast Neoplasms 28430743 MicroRNA-148a promotes apoptosis and suppresses growth of breast cancer cells by targeting B-cell lymphoma 2. -target gene hsa-mir-9 Glioma 28430789 MiR-9-3p augments apoptosis induced by H2O2 through down regulation of Herpud1 in glioma. -target gene hsa-mir-429 Fibrosarcoma 28432002 miR-429 inhibits metastasis by targeting KIAA0101 in Soft Tissue Sarcoma. -target gene hsa-mir-590 Colorectal Carcinoma 28433598 "MiR-590-5p, a density-sensitive microRNA, inhibits tumorigenesis by targeting YAP1 in colorectal cancer." -target gene hsa-mir-146a Diabetic Retinopathy 28433754 miR-146a suppresses STAT3/VEGF pathways and reduces apoptosis through IL-6 signaling in primary human retinal microvascular endothelial cells in high glucose conditions. -target gene hsa-let-7b Nervous System Diseases [unspecific] 28436683 Dexmedetomidine Protects PC12 Cells from Lidocaine-Induced Cytotoxicity Through Downregulation of COL3A1 Mediated by miR-let-7b. -target gene hsa-mir-217 "Carcinoma, Breast, Triple Negative" 28437471 "miR-217 inhibits triple-negative breast cancer cell growth, migration, and invasion through targeting KLF5." -target gene hsa-mir-124 Pediatric Ependymoma 28437838 Prognostic relevance of miR-124-3p and its target TP53INP1 in pediatric ependymoma. -target gene hsa-mir-200a "Carcinoma, Hepatocellular" 28440466 miR-200a targets Gelsolin: A novel mechanism regulating secretion of microvesicles in hepatocellular carcinoma cells. -target gene hsa-mir-200a "Carcinoma, Breast" 28440475 "A nine-miRNA signature as a potential diagnostic marker for breast carcinoma: An integrated study of 1,110 cases." -target gene hsa-mir-15a Ischemia-Reperfusion Injury 28440490 MicroRNA-15a inhibition protects against hypoxia/reoxygenation-induced apoptosis of cardiomyocytes by targeting mothers against decapentaplegic homolog 7. -target gene hsa-mir-1185 Atherosclerosis 28441650 MicroRNA-1185 Induces Endothelial Cell Apoptosis by Targeting UVRAG and KRIT1. -target gene hsa-mir-1185 Atherosclerosis 28441665 MicroRNA-1185 Promotes Arterial Stiffness though Modulating VCAM-1 and E-Selectin Expression. -target gene hsa-mir-221 "Carcinoma, Hepatocellular" 28442344 miR-221 regulates CD44 in hepatocellular carcinoma through the PI3K-AKT-mTOR pathway. -target gene hsa-mir-30a Diabetic Cataract 28442786 MicroRNA-30a Regulation of Epithelial-Mesenchymal Transition in Diabetic Cataracts Through Targeting SNAI1. -target gene hsa-mir-1202 Glioma 28443461 MiR-1202 functions as a tumor suppressor in glioma cells by targeting Rab1A. -target gene hsa-mir-30c "Carcinoma, Lung, Non-Small-Cell" 28443468 Curcumin increases the sensitivity of Paclitaxel-resistant NSCLC cells to Paclitaxel through microRNA-30c-mediated MTA1 reduction. -target gene hsa-mir-590 "Carcinoma, Breast" 28443471 Suppressing the molecular signaling pathways involved in inflammation and cancer in breast cancer cell lines MDA-MB-231 and MCF-7 by miR-590. -target gene hsa-mir-26a Colorectal Carcinoma 28443472 MiR-26a downregulates retinoblastoma in colorectal cancer. -target gene hsa-mir-340 Osteosarcoma 28443990 MicroRNA-340-5p modulates cisplatin resistance by targeting LPAAT¦Â in osteosarcoma. -target gene hsa-mir-125a "Carcinoma, Hepatocellular" 28445974 "Lowered expression of microRNA-125a-5p in human hepatocellular carcinoma and up-regulation of its oncogenic targets sirtuin-7, matrix metalloproteinase-11, and c-Raf." -target gene hsa-mir-181a Gastric Neoplasms 28447759 "miR-181a modulates proliferation, migration and autophagy in AGS gastric cancer cells and downregulates MTMR3." -target gene hsa-mir-193a Neoplasms [unspecific] 28449010 "Excess of a Rassf1-targeting microRNA, miR-193a-3p, perturbs cell division fidelity." -target gene hsa-mir-31 "Squamous Cell Carcinoma, Skin or Unspecific" 28454216 MicroRNA-31 functions as an oncogenic microRNA in cutaneous squamous cell carcinoma cells by targeting RhoTBT1. -target gene hsa-mir-29a "Fatty Liver, Non-Alcoholic" 28454323 MicroRNA-29a/b/c targets iNOS and is involved in protective remote ischemic preconditioning in an ischemia-reperfusion rat model of non-alcoholic fatty liver disease. -target gene hsa-mir-29b "Fatty Liver, Non-Alcoholic" 28454323 MicroRNA-29a/b/c targets iNOS and is involved in protective remote ischemic preconditioning in an ischemia-reperfusion rat model of non-alcoholic fatty liver disease. -target gene hsa-mir-29c "Fatty Liver, Non-Alcoholic" 28454323 MicroRNA-29a/b/c targets iNOS and is involved in protective remote ischemic preconditioning in an ischemia-reperfusion rat model of non-alcoholic fatty liver disease. -target gene hsa-mir-150 Osteosarcoma 28454380 "miR-150 is downregulated in osteosarcoma and suppresses cell proliferation, migration and invasion by targeting ROCK1." -target gene hsa-mir-409 "Carcinoma, Breast" 28459205 MicroRNA-409-5p is upregulated in breast cancer and its downregulation inhibits cancer development through downstream target of RSU1. -target gene hsa-mir-200c "Carcinoma, Nasopharyngeal" 28459373 MicroRNA-200c plays an oncogenic role in nasopharyngeal carcinoma by targeting PTEN. -target gene hsa-mir-181b Glioblastoma 28459461 MiR-181b modulates EGFR-dependent VCAM-1 expression and monocyte adhesion in glioblastoma. -target gene hsa-mir-21 Atherosclerosis 28460288 Thrombin-activated platelet-derived exosomes regulate endothelial cell expression of ICAM-1 via microRNA-223 during the thrombosis-inflammation response. -target gene hsa-mir-223 Atherosclerosis 28460288 Thrombin-activated platelet-derived exosomes regulate endothelial cell expression of ICAM-1 via microRNA-223 during the thrombosis-inflammation response. -target gene hsa-mir-19b "Leukemia, Myeloid, Chronic" 28461114 miR-17-92 promotes leukemogenesis in chronic myeloid leukemia via targeting A20 and activation of NF-¦ÊB signaling. -target gene hsa-mir-155 "Colitis, Ulcerative" 28461115 MiR-155 contributes to Th17 cells differentiation in dextran sulfate sodium (DSS)-induced colitis mice via Jarid2. -target gene hsa-mir-1228 "Carcinoma, Gastric" 28465246 microRNA-1228? impairs the pro-angiogenic activity of gastric cancer cells by targeting macrophage migration inhibitory factor. -target gene hsa-mir-145 Obstructive Sleep Apnea 28465478 Chronic obstructive sleep apnea promotes aortic remodeling in canines through miR-145/Smad3 signaling pathway. -target gene hsa-mir-133a "Carcinoma, Colon" 28466778 miR-133a acts as a tumor suppressor in colorectal cancer by targeting eIF4A1. -target gene hsa-mir-1 Colorectal Carcinoma 28471448 MiR-1 suppresses tumor cell proliferation in colorectal cancer by inhibition of Smad3-mediated tumor glycolysis. -target gene hsa-mir-19a Osteosarcoma 28475001 MiR-19a regulates the cell growth and apoptosis of osteosarcoma stem cells by targeting PTEN. -target gene hsa-mir-493 Melanoma 28475006 Downregulation of miR-493 promoted melanoma proliferation by suppressing IRS4 expression. -target gene hsa-mir-34a "Leukemia, Myeloid, Acute" 28478444 MiR-34a Promotes Apoptosis and Inhibits Autophagy by Targeting HMGB1 in Acute Myeloid Leukemia Cells. -target gene hsa-mir-1301 Prostate Neoplasms 28483517 MicroRNA-1301 suppresses tumor cell migration and invasion by targeting the p53/UBE4B pathway in multiple human cancer cells. -target gene hsa-mir-34a Atherosclerosis 28485501 miR-34a Targets HDAC1-Regulated H3K9 Acetylation on Lipid Accumulation Induced by Homocysteine in Foam Cells. -target gene hsa-mir-146a Thyroid-Associated Ophthalmopathy 28485799 Decreased microRNA-146a in CD4+T cells promote ocular inflammation in thyroid-associated ophthalmopathy by targeting NUMB. -target gene hsa-mir-223 Inflammatory Bowel Diseases 28487310 Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome. -target gene hsa-mir-23b Colorectal Carcinoma 28487386 "our results define a critical function for miR-23b, which, by targeting LGR5, contributes to overpopulation of ALDH+ CSCs and colorectal cancer" -target gene hsa-mir-195 "Carcinoma, Esophageal" 28487599 miR-195 Regulates Proliferation and Apoptosis through Inhibiting the mTOR/p70s6k Signaling Pathway by Targeting HMGA2 in Esophageal Carcinoma Cells. -target gene hsa-mir-124 "Carcinoma, Lung, Non-Small-Cell" 28488541 MicroRNA-124 suppresses proliferation and glycolysis in non-small cell lung cancer cells by targeting AKT-GLUT1/HKII. -target gene hsa-mir-106b Gastric Neoplasms 28489839 Deregulation of microRNAs in gastric cancer: up regulation by miR-21 and miR-106. -target gene hsa-let-7a Psoriasis 28494466 Let-7a Inhibits T-Cell Proliferation and IFN-¦Ã Secretion by Down-Regulating STAT3 Expression in Patients with Psoriasis. -target gene hsa-mir-21 Atrial Fibrillation 28495464 MicroRNA-21 via Dysregulation of WW Domain-Containing Protein 1 Regulate Atrial Fibrosis in Atrial Fibrillation. -target gene hsa-mir-21 "Carcinoma, Cervical" 28495512 Modulation of CASC2/miR-21/PTEN pathway sensitizes cervical cancer to cisplatin. -target gene hsa-mir-16 Glioblastoma 28497156 Tumor suppressors microRNA-302d and microRNA-16 inhibit human glioblastoma multiforme by targeting NF-¦ÊB and FGF2. -target gene hsa-mir-302d Glioblastoma 28497156 Tumor suppressors microRNA-302d and microRNA-16 inhibit human glioblastoma multiforme by targeting NF-¦ÊB and FGF2. -target gene hsa-mir-15 "Carcinoma, Lung, Non-Small-Cell" 28498424 MicroRNA-15b promotes proliferation and invasion of non?small cell lung carcinoma cells by directly targeting TIMP2. -target gene hsa-mir-24-1 Liver Neoplasms 28499244 MicroRNA-24-1 suppresses mouse hepatoma cell invasion and metastasis via directly targeting O-GlcNAc transferase. -target gene hsa-mir-375 "Squamous Cell Carcinoma, Head and Neck" 28499703 miR-375 Regulates Invasion-Related Proteins Vimentin and L-Plastin. -target gene hsa-mir-140 Spinal Cord Injuries 28501777 MiR-140/BDNF axis regulates normal human astrocyte proliferation and LPS-induced IL-6 and TNF-¦Á secretion. -target gene hsa-mir-874 "Carcinoma, Lung, Non-Small-Cell" 28501870 Long Non-Coding RNA XLOC_008466 Functions as an Oncogene in Human Non-Small Cell Lung Cancer by Targeting miR-874. -target gene hsa-mir-181b Glioblastoma 28501897 MiR-181b modulates chemosensitivity of glioblastoma multiforme cells to temozolomide by targeting the epidermal growth factor receptor. -target gene hsa-mir-183 "Carcinoma, Pancreatic" 28506766 "Effects of microRNA-183 on epithelial-mesenchymal transition, proliferation, migration, invasion and apoptosis in human pancreatic cancer SW1900 cells by targeting MTA1." -target gene hsa-mir-21 "Hand, Foot And Mouth Disease" 28506791 Enterovirus 71-induced has-miR-21 contributes to evasion of host immune system by targeting MyD88 and IRAK1. -target gene hsa-mir-143 Breast Adenocarcinoma 28511343 Restoration of miR-143 expression could inhibit migration and growth of MDA-MB-468 cells through down-regulating the expression of invasion-related factors. -target gene hsa-mir-513b Embryonal Testis Carcinoma 28512062 Hsa-miR-513b-5p suppresses cell proliferation and promotes P53 expression by targeting IRF2 in testicular embryonal carcinoma cells. -target gene hsa-mir-130a Pulmonary Hypertension 28514291 Role of microRNA-130a in the pathogeneses of obstructive sleep apnea hypopnea syndrome-associated pulmonary hypertension by targeting the GAX gene. -target gene hsa-mir-106b Breast Neoplasms 28518139 MiR-106b and miR-93 regulate cell progression by suppression of PTEN via PI3K/Akt pathway in breast cancer. -target gene hsa-mir-29a "Carcinoma, Lung, Non-Small-Cell" 28521487 MicroRNA-29a functions as a potential tumor suppressor through directly targeting CDC42 in non-small cell lung cancer. -target gene hsa-mir-181a Stroke 28522364 Inhibition of miR-181a protects female mice from transient focal cerebral ischemia by targeting astrocyte estrogen receptor-¦Á. -target gene hsa-mir-34b Neuroblastoma 28525978 miRNA-34b is able to significantly downregulate DLL1 mRNA expression levels -target gene hsa-mir-200a Melanoma 28526299 MiR-200a Regulates CDK4/6 Inhibitor Effect by Targeting CDK6 in Metastatic?Melanoma. -target gene hsa-mir-195 "Carcinoma, Hepatocellular" 28529562 miR-195 inhibits cell proliferation via targeting AEG-1 in hepatocellular carcinoma. -target gene hsa-mir-200b "Carcinoma, Endometrial" 28529604 "knockdown of DICER1 significantly downregulated miR-200b and let-7i, which may then regulate their targets SUZ12 and EZH2" -target gene hsa-mir-16 Hypertension 28531963 MiR-19b and miR-16 cooperatively signaling target the regulator ADRA1A in Hypertensive heart disease. -target gene hsa-mir-19b Hypertension 28531963 MiR-19b and miR-16 cooperatively signaling target the regulator ADRA1A in Hypertensive heart disease. -target gene hsa-mir-145 Colorectal Carcinoma 28534337 MiR-145 inhibits drug resistance to Oxaliplatin in colorectal cancer cells through regulating G protein coupled receptor 98. -target gene hsa-mir-204 Breast Neoplasms 28534958 miR-204 regulates the biological behavior of breast cancer MCF-7 cells by directly targeting FOXA1. -target gene hsa-mir-34a "Squamous Cell Carcinoma, Esophageal" 28534990 Tumor suppressor microRNA-34a inhibits cell migration and invasion by targeting MMP-2/MMP-9/FNDC3B in esophageal squamous cell carcinoma. -target gene hsa-mir-424 "Carcinoma, Lung, Non-Small-Cell" 28535539 MiR-424 Promotes Non-Small Cell Lung Cancer Progression and Metastasis through Regulating the Tumor Suppressor Gene TNFAIP1. -target gene hsa-mir-181a "Carcinoma, Lung, Small-Cell" 28535543 MicroRNA-181a-5p Impedes IL-17-Induced Nonsmall Cell Lung Cancer Proliferation and Migration through Targeting VCAM-1. -target gene hsa-mir-200b Melanoma 28535666 A miR-200b inhibitor induced the direct regulation of SOX-2 by DDX53 -target gene hsa-mir-30b "Carcinoma, Renal Cell" 28536082 "MiR-30b-5p functions as a tumor suppressor in cell proliferation, metastasis and epithelial-to-mesenchymal transition by targeting G-protein subunit ¦Á-13 in renal cell carcinoma." -target gene hsa-let-7 Liver Injury 28536261 The let-7/Lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury. -target gene hsa-mir-126 "Carcinoma, Esophageal" 28536606 The crucial role of miR-126 on suppressing progression of esophageal cancer by targeting VEGF-A. -target gene hsa-mir-210 Atherosclerosis 28536634 MicroRNA-210 induces endothelial cell apoptosis by directly targeting PDK1 in the setting of atherosclerosis. -target gene hsa-mir-129 Neoplasms [unspecific] 28536635 "the regulation of NG2 expression underlies inflammation and hypoxia and is mediated by methyltransferases, transcription factors, including Sp1, paired box (Pax) 3 and Egr-1, and the microRNA miR129-2" -target gene hsa-mir-19a Ileus 28537131 Acupuncture Ameliorates Postoperative Ileus via IL-6-miR-19a-KIT Axis to Protect Interstitial Cells of Cajal. -target gene hsa-mir-20a "Carcinoma, Hepatocellular" 28537677 Targeting of miR-20a against CFLAR to potentiate TRAIL-induced apoptotic sensitivity in HepG2 cells. -target gene hsa-mir-221 "Carcinoma, Hepatocellular" 28539268 MiR-221 mediates the epithelial-mesenchymal transition of hepatocellular carcinoma by targeting AdipoR1. -target gene hsa-mir-29c Diabetes Mellitus 28539664 MiRNA-29c regulates the expression of inflammatory cytokines in diabetic nephropathy by targeting tristetraprolin. -target gene hsa-mir-200c Colorectal Carcinoma 28543447 Fas signaling induces stemness properties in colorectal cancer by regulation of Bmi1. -target gene hsa-mir-106b Preeclampsia 28545271 Effect of microRNA-106b on the invasion and proliferation of trophoblasts through targeting MMP-2. -target gene hsa-mir-182 Breast Neoplasms 28546132 "Identification of direct target genes of miR-7, miR-9, miR-96, and miR-182 in the human breast cancer cell lines MCF-7 and MDA-MB-231." -target gene hsa-mir-7 Breast Neoplasms 28546132 "Identification of direct target genes of miR-7, miR-9, miR-96, and miR-182 in the human breast cancer cell lines MCF-7 and MDA-MB-231." -target gene hsa-mir-9 Breast Neoplasms 28546132 "Identification of direct target genes of miR-7, miR-9, miR-96, and miR-182 in the human breast cancer cell lines MCF-7 and MDA-MB-231." -target gene hsa-mir-96 Breast Neoplasms 28546132 "Identification of direct target genes of miR-7, miR-9, miR-96, and miR-182 in the human breast cancer cell lines MCF-7 and MDA-MB-231." -target gene hsa-mir-150 Osteosarcoma 28547952 Mir-150 Up-Regulates Glut1 and Increases Glycolysis in Osteosarcoma Cells -target gene hsa-mir-26a Mycobacterium tuberculosis Infection 28558034 "MicroRNA 26a (miR-26a)/KLF4 and CREB-C/EBP¦Â regulate innate immune signaling, the polarization of macrophages and the trafficking of Mycobacterium tuberculosis to lysosomes during infection." -target gene hsa-mir-143 Breast Neoplasms 28559978 miR-143-3p targeting LIM domain kinase 1 suppresses the progression of triple-negative breast cancer cells. -target gene hsa-mir-146b Colorectal Carcinoma 28560062 "miR-146b-5p regulates cell growth, invasion, and metabolism by targeting PDHB in colorectal cancer." -target gene hsa-mir-17 Neuroblastoma 28560387 Reciprocal antagonistic regulation of N-myc mRNA by miR?17 and the neuronal-specific RNA-binding protein HuD. -target gene hsa-mir-20a Neuroblastoma 28560387 Reciprocal antagonistic regulation of N-myc mRNA by miR?17 and the neuronal-specific RNA-binding protein HuD. -target gene hsa-mir-146a Gastric Neoplasms 28560435 MicroRNA-146a promotes gastric cancer cell apoptosis by targeting transforming growth factor ¦Â-activated kinase 1. -target gene hsa-mir-155 "Carcinoma, Renal Cell, Clear-Cell" 28565840 Overexpression of miR-155 in clear-cell renal cell carcinoma and its oncogenic effect through targeting FOXO3a. -target gene hsa-mir-125b "Carcinoma, Nasopharyngeal" 28569771 MiR-125b regulates proliferation and apoptosis of nasopharyngeal carcinoma by targeting A20/NF-¦ÊB signaling pathway. -target gene hsa-mir-211 "Carcinoma, Breast, Triple Negative" 28571042 "MicroRNA-211-5p suppresses tumour cell proliferation, invasion, migration and metastasis in triple-negative breast cancer by directly targeting SETBP1." -target gene hsa-mir-21 Neoplasms [unspecific] 28571917 Targeting miR-21 with Sophocarpine Inhibits Tumor Progression and Reverses Epithelial-Mesenchymal Transition in Head and Neck Cancer. -target gene hsa-mir-124 "Leukemia, Lymphoblastic, Acute" 28578002 "MiR-124 contributes to glucocorticoid resistance in acute lymphoblastic leukemia by promoting proliferation, inhibiting apoptosis and targeting the glucocorticoid receptor." -target gene hsa-mir-124 "Carcinoma, Nasopharyngeal" 28579809 miR-124 suppresses proliferation and invasion of nasopharyngeal carcinoma cells through the Wnt/¦Â-catenin signaling pathway by targeting Capn4. -target gene hsa-mir-873 Glioma 28583401 miR-873 suppresses H9C2 cardiomyocyte proliferation by targeting GLI1. -target gene hsa-mir-199b "Carcinoma, Hepatocellular" 28588321 MicroRNA-199b-5p attenuates TGF-¦Â1-induced epithelial-mesenchymal transition in hepatocellular carcinoma. -target gene hsa-mir-18a Ovarian Neoplasms 28588697 MicroRNA-18a inhibits ovarian cancer growth via directly targeting TRIAP1 and IPMK. -target gene hsa-mir-141 Glioma 28595907 miR-141-3p functions as a tumor suppressor modulating activating transcription factor 5 in glioma. -target gene hsa-mir-150 Myocardial Infarction 28597963 miR-181a and miR-150 regulate dendritic cell immune inflammatory responses and cardiomyocyte apoptosis via targeting JAK1-STAT1/c-Fos pathway. -target gene hsa-mir-181a Myocardial Infarction 28597963 miR-181a and miR-150 regulate dendritic cell immune inflammatory responses and cardiomyocyte apoptosis via targeting JAK1-STAT1/c-Fos pathway. -target gene hsa-mir-126 Diabetes Mellitus 28598282 MicroRNA-126 Regulates Inflammatory Cytokine Secretion in Human Gingival Fibroblasts Under High Glucose via Targeting Tumor Necrosis Factor Receptor Associated Factor 6. -target gene hsa-mir-155 Prostate Neoplasms 28599307 Morin promotes prostate cancer cells chemosensitivity to paclitaxel through miR-155/GATA3 axis. -target gene hsa-mir-375 Esophageal Neoplasms 28599478 MicroRNA-375 suppresses esophageal cancer cell growth and invasion by repressing metadherin expression. -target gene hsa-mir-630 "Carcinoma, Gastric" 28601080 MicroRNA-630 Suppresses Epithelial-to-Mesenchymal Transition by Regulating FoxM1 in Gastric Cancer Cells. -target gene hsa-mir-200c "Carcinoma, Hepatocellular" 28609841 MiR-200c-5p suppresses proliferation and metastasis of human hepatocellular carcinoma (HCC) via suppressing MAD2L1. -target gene hsa-mir-137 "Carcinoma, Lung, Non-Small-Cell" 28610956 Upregulation of microRNA-137 expression by Slug promotes tumor invasion and metastasis of non-small cell lung cancer cells through suppression of TFAP2C. -target gene hsa-mir-222 "Adenocarcinoma, Lung" 28617551 "MiR-222 promotes proliferation, migration and invasion of lung adenocarcinoma cells by targeting ETS1." -target gene hsa-mir-1 "Carcinoma, Bladder" 28618950 MiR-1-3p inhibits the proliferation and invasion of bladder cancer cells by suppressing CCL2 expression. -target gene hsa-mir-105 Glioma 28618952 MicroRNA-105 inhibits human glioma cell malignancy by directly targeting SUZ12. -target gene hsa-mir-208b Osteosarcoma 28618961 MicroRNA-208b inhibits human osteosarcoma progression by targeting ROR2. -target gene hsa-mir-221 "Carcinoma, Gastric" 28618968 miR-221 and miR-222 synergistically regulate hepatocyte growth factor activator inhibitor type 1 to promote cell proliferation and migration in gastric cancer. -target gene hsa-mir-222 "Carcinoma, Gastric" 28618968 miR-221 and miR-222 synergistically regulate hepatocyte growth factor activator inhibitor type 1 to promote cell proliferation and migration in gastric cancer. -target gene hsa-mir-31 "Carcinoma, Hepatocellular" 28623129 "Increased expression of microRNA-31-5p inhibits cell proliferation, migration, and invasion via regulating Sp1 transcription factor in HepG2 hepatocellular carcinoma cell line." -target gene hsa-mir-375 "Squamous Cell Carcinoma, Oral" 28627030 MiR-375/SLC7A11 axis regulates oral squamous cell carcinoma proliferation and invasion. -target gene hsa-mir-495 Preeclampsia 28628915 MiR-495 Promotes Senescence of Mesenchymal Stem Cells by Targeting Bmi-1. -target gene hsa-mir-330 "Carcinoma, Lung, Non-Small-Cell" 28629431 MicroRNA-330-3p promotes cell invasion and metastasis in non-small cell lung cancer through GRIA3 by activating MAPK/ERK signaling pathway. -target gene hsa-mir-500 "Carcinoma, Prostate" 28631332 Inhibition of microRNA-500 has anti-cancer effect through its conditional downstream target of TFPI in human prostate cancer. -target gene hsa-mir-1285 "Carcinoma, Lung, Non-Small-Cell" 28631567 MicroRNA-1285-5p influences the proliferation and metastasis of non-small-cell lung carcinoma cells via downregulating CDH1 and Smad4. -target gene hsa-mir-1236 "Carcinoma, Lung" 28631573 Effects of miR-1236-3p and miR-370-5p on activation of p21 in various tumors and its inhibition on the growth of lung cancer cells. -target gene hsa-mir-370 "Carcinoma, Lung" 28631573 Effects of miR-1236-3p and miR-370-5p on activation of p21 in various tumors and its inhibition on the growth of lung cancer cells. -target gene hsa-mir-125a "Carcinoma, Lung" 28631574 MicroRNA-125a-5p plays a role as a tumor suppressor in lung carcinoma cells by directly targeting STAT3. -target gene hsa-mir-646 "Carcinoma, Gastric" 28632723 MiR-646 inhibited cell proliferation and EMT-induced metastasis by targeting FOXK1 in gastric cancer. -target gene hsa-mir-146a Osteoarthritis 28634214 Effects of microRNA-146a on the proliferation and apoptosis of human osteochondrocytes by targeting TRAF6 through the NF- ¦ÊB signalling pathway. -target gene hsa-mir-148a Glomerulonephritis 28637300 "The type of diet intake also influenced cytokine production, fecal microbiota (increased Lachnospiraceae in mice fed on 2018), altered microRNAs (miRNAs; higher levels of lupus-associated miR-148a and miR-183 in mice fed on 7013 and/or 2018) and altered DNA methylation." -target gene hsa-mir-183 Glomerulonephritis 28637300 "The type of diet intake also influenced cytokine production, fecal microbiota (increased Lachnospiraceae in mice fed on 2018), altered microRNAs (miRNAs; higher levels of lupus-associated miR-148a and miR-183 in mice fed on 7013 and/or 2018) and altered DNA methylation." -target gene hsa-mir-26a "Carcinoma, Breast" 28637868 Post-transcriptional regulation of ERBB2 by miR26a/b and HuR confers resistance to tamoxifen in estrogen receptor-positive breast cancer cells. -target gene hsa-mir-26b "Carcinoma, Breast" 28637868 Post-transcriptional regulation of ERBB2 by miR26a/b and HuR confers resistance to tamoxifen in estrogen receptor-positive breast cancer cells. -target gene hsa-mir-195 "Carcinoma, Pancreatic" 28639885 MicroRNA-195 inhibits the proliferation and invasion of pancreatic cancer cells by targeting the fatty acid synthase/Wnt signaling pathway. -target gene hsa-mir-138 "Carcinoma, Hepatocellular" 28639887 MicroRNA-138 enhances TRAIL-induced apoptosis through interferon-stimulated gene 15 downregulation in hepatocellular carcinoma cells. -target gene hsa-mir-557 "Carcinoma, Lung" 28639890 MiR-557 works as a tumor suppressor in human lung cancers by negatively regulating LEF1 expression. -target gene hsa-mir-193a "Carcinoma, Renal Cell" 28639901 Downregulation of miR-193a-3p inhibits cell growth and migration in renal cell carcinoma by targeting PTEN. -target gene hsa-mir-26a "Lymphoma, Large B-Cell, Diffuse" 28640256 "MicroRNA-26a/cyclin-dependent kinase 5 axis controls proliferation, apoptosis and in vivo tumor growth of diffuse large B-cell lymphoma cell lines." -target gene hsa-mir-26a Colorectal Carcinoma 28640257 Tumor-suppressive miR-26a and miR-26b inhibit cell aggressiveness by regulating FUT4 in colorectal cancer. -target gene hsa-mir-26b Colorectal Carcinoma 28640257 Tumor-suppressive miR-26a and miR-26b inhibit cell aggressiveness by regulating FUT4 in colorectal cancer. -target gene hsa-mir-337 "Carcinoma, Cervical" 28641487 MicroRNA-337 inhibits cell proliferation and invasion of cervical cancer through directly targeting specificity protein 1. -target gene hsa-mir-133b "Carcinoma, Lung" 28641694 MiR-133b Affect the Proliferation and Drug Sensitivity in A549 Lung Cancer Stem Cells by Targeting PKM2. -target gene hsa-mir-217 Cardiac Myxoma 28642131 miR-217 suppresses proliferation and promotes apoptosis in cardiac myxoma by targeting Interleukin-6. -target gene hsa-mir-205 "Carcinoma, Cervical" 28651495 MiR-205 serves as a prognostic factor and suppresses proliferation and invasion by targeting insulin-like growth factor receptor 1 in human cervical cancer. -target gene hsa-mir-144 "Carcinoma, Pancreatic" 28653602 "miR-144-3p Targets FosB Proto-oncogene, AP-1 Transcription Factor Subunit (FOSB) to Suppress Proliferation, Migration, and Invasion of PANC-1 Pancreatic Cancer Cells." -target gene hsa-mir-181a "Carcinoma, Cervical" 28653606 miR-181a-5p Promotes Proliferation and Invasion and Inhibits Apoptosis of Cervical Cancer Cells via Regulating Inositol Polyphosphate-5-Phosphatase A (INPP5A). -target gene hsa-mir-129 "Carcinoma, Gastric" 28653880 MiR-129-5p influences the progression of gastric cancer cells through interacting with SPOCK1. -target gene hsa-mir-150 "Carcinoma, Thyroid, Papillary" 28656254 "MicroRNA-150 targets Rho-associated protein kinase 1 to inhibit cell proliferation, migration and invasion in papillary thyroid carcinoma." -target gene hsa-mir-148b Melanoma 28656878 Proteasome beta-4 subunit contributes to the development of melanoma and is regulated by miR-148b. -target gene hsa-mir-136 "Carcinoma, Gastric" 28656883 MiR-136 inhibits gastric cancer-specific peritoneal metastasis by targeting HOXC10. -target gene hsa-mir-210 Ischemic Diseases [unspecific] 28661226 MicroRNA-210 alleviates oxidative stress-associated cardiomyocyte apoptosis by regulating BNIP3. -target gene hsa-mir-146a Sepsis 28662100 "miR-146a, miR-146b, and miR-155 increase expression of IL-6 and IL-8 and support HSP10 in an In vitro sepsis model." -target gene hsa-mir-146b Sepsis 28662100 "miR-146a, miR-146b, and miR-155 increase expression of IL-6 and IL-8 and support HSP10 in an In vitro sepsis model." -target gene hsa-mir-155 Sepsis 28662100 "miR-146a, miR-146b, and miR-155 increase expression of IL-6 and IL-8 and support HSP10 in an In vitro sepsis model." -target gene hsa-mir-34a "Carcinoma, Hepatocellular" 28667294 0404 inhibits hepatocellular carcinoma through a p53/miR-34a/SIRT1 positive feedback loop. -target gene hsa-mir-34a "Carcinoma, Hepatocellular" 28667334 3'UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma. -target gene hsa-mir-16 Gastric Neoplasms 28667493 MiR-16-1 Targeted Silences Far Upstream Element Binding Protein 1 to Advance the Chemosensitivity to Adriamycin in Gastric Cancer. -target gene hsa-mir-155 "Carcinoma, Salivary Adenoid Cystic" 28668836 MicroRNA Profiling and Target Genes Related to Metastasis of Salivary Adenoid Cystic Carcinoma. -target gene hsa-mir-205 "Carcinoma, Salivary Adenoid Cystic" 28668836 MicroRNA Profiling and Target Genes Related to Metastasis of Salivary Adenoid Cystic Carcinoma. -target gene hsa-mir-664a Osteosarcoma 28669734 Inhibition of miR-664a interferes with the migration of osteosarcoma cells via modulation of MEG3. -target gene hsa-let-7b "Carcinoma, Hepatocellular" 28671046 Let7b modulates the Wnt/¦Â-catenin pathway in liver cancer cells via downregulated Frizzled4. -target gene hsa-mir-204 "Carcinoma, Breast" 28675122 MiR-204/ZEB2 axis functions as key mediator for MALAT1-induced epithelial-mesenchymal transition in breast cancer. -target gene hsa-mir-372 Pancreatic Adenocarcinoma 28677209 Downregulation of ULK1 by microRNA-372 inhibits the survival of human pancreatic adenocarcinoma cells. -target gene hsa-mir-138 "Carcinoma, Hepatocellular" 28677784 MicroRNA-138 inhibits cell proliferation in hepatocellular carcinoma by targeting Sirt1. -target gene hsa-mir-30a Lung Neoplasms 28678320 MiR-30 suppresses lung cancer cell 95D epithelial mesenchymal transition and invasion through targeted regulating Snail. -target gene hsa-mir-107 Osteosarcoma 28682874 In vitro effect of microRNA-107 targeting Dkk-1 by regulation of Wnt/¦Â-catenin signaling pathway in osteosarcoma -target gene hsa-mir-150 Neuropathic Pain 28685867 MiR-150 alleviates neuropathic pain via inhibiting toll-like receptor 5. -target gene hsa-mir-34a Atherosclerosis 28688900 MiR-34a/sirtuin-1/foxo3a is involved in genistein protecting against ox-LDL-induced oxidative damage in HUVECs. -target gene hsa-mir-155 Lung Neoplasms 28688901 MicroRNA-155 regulates arsenite-induced malignant transformation by targeting Nrf2-mediated oxidative damage in human bronchial epithelial cells. -target gene hsa-mir-200b "Carcinoma, Hepatocellular" 28695771 MicroRNA-200b suppresses the invasion and migration of hepatocellular carcinoma by downregulating RhoA and circRNA_000839. -target gene hsa-mir-125b "Carcinoma, Nasopharyngeal" 28698199 MiR-125b Increases Nasopharyngeal Carcinoma Radioresistance by Targeting A20/NF-¦ÊB Signaling Pathway. -target gene hsa-let-7a Melanoma 28698805 MicroRNA-26a inhibits the growth and invasiveness of malignant melanoma and directly targets on MITF gene. -target gene hsa-mir-26a Melanoma 28698805 MicroRNA-26a inhibits the growth and invasiveness of malignant melanoma and directly targets on MITF gene. -target gene hsa-mir-613 Gastric Neoplasms 28701053 MicroRNA-613 inhibits the progression of gastric cancer by targeting CDK9. -target gene hsa-mir-25 Osteosarcoma 28705117 "MicroRNA-25 suppresses proliferation, migration, and invasion of osteosarcoma by targeting SOX4." -target gene hsa-mir-145 Retinoblastoma 28706438 Genistein suppresses retinoblastoma cell viability and growth and induces apoptosis by upregulating miR-145 and inhibiting its target ABCE1. -target gene hsa-mir-138 Colorectal Carcinoma 28707774 "Hsa_circ_0020397 regulates colorectal cancer cell viability, apoptosis and invasion by promoting the expression of the miR-138 targets TERT and PD-L1." -target gene hsa-mir-320 Gastric Neoplasms 28713899 miR-320a serves as a negative regulator in the progression of gastric cancer by targeting RAB14. -target gene hsa-mir-34a "Carcinoma, Colon" 28713966 Spica Prunellae extract suppresses the growth of human colon carcinoma cells by targeting multiple oncogenes via activating miR-34a. -target gene hsa-mir-125b "Carcinoma, Lung, Non-Small-Cell" 28713974 miRNA-125b regulates apoptosis of human non-small cell lung cancer via the PI3K/Akt/GSK3¦Â signaling pathway. -target gene hsa-mir-219 "Carcinoma, Lung, Non-Small-Cell" 28714014 MicroRNA-219 is downregulated in non-small cell lung cancer and inhibits cell growth and metastasis by targeting HMGA2. -target gene hsa-mir-200a "Carcinoma, Renal Cell" 28717923 MiRNA-200a induce cell apoptosis in renal cell carcinoma by directly targeting SIRT1. -target gene hsa-mir-143 "Carcinoma, Gastric" 28718369 MiR-143 inhibits cell proliferation and invasion by targeting DNMT3A in gastric cancer. -target gene hsa-mir-592 Glioma 28718372 MiR-592 functions as a tumor suppressor in glioma by targeting IGFBP2. -target gene hsa-mir-139 "Carcinoma, Bladder" 28720065 MicroRNA-139-5p inhibits bladder cancer proliferation and self-renewal by targeting the Bmi1 oncogene. -target gene hsa-mir-375 Melanoma 28723760 "CXCL8 interacted with STAT1, CCL27, and IGF1R targeted by hsa-miR-375" -target gene hsa-mir-378 Colon Neoplasms 28725241 "miR-378 suppresses the proliferation, migration and invasion of colon cancer cells by inhibiting SDAD1." -target gene hsa-mir-200c Lung Neoplasms 28727734 "MicroRNA-200c inhibits epithelial-mesenchymal transition, invasion, and migration of lung cancer by targeting HMGB1." -target gene hsa-let-7c Breast Neoplasms 28731186 Let-7c-5p inhibits cell proliferation and induces cell apoptosis by targeting ERCC6 in breast cancer -target gene hsa-mir-181a "Leukemia, Lymphoblastic, Acute" 28732737 MicroRNA-181a and its target Smad 7 as potential biomarkers for tracking child acute lymphoblastic leukemia -target gene hsa-mir-143 Osteosarcoma 28734729 MiR-143 regulates the proliferation and migration of osteosarcoma cells through targeting MAPK7. -target gene hsa-mir-27b "Squamous Cell Carcinoma, Oral" 28735227 MicroRNA-27b inhibits cell proliferation in oral squamous cell carcinoma by targeting FZD7 and Wnt signaling pathway. -target gene hsa-mir-143 Lymphoma 28736328 Down regulation of miR-143 promotes radiation - Induced thymic lymphoma by targeting B7H1. -target gene hsa-mir-21 Ischemia-Reperfusion Injury 28737660 Renal Protection Mediated by Hypoxia Inducible Factor-1¦Á Depends on Proangiogenesis Function of miR-21 by Targeting Thrombospondin 1. -target gene hsa-mir-21 Pituitary Neoplasms 28742208 Effects of microRNA-21 targeting PITX2 on proliferation and apoptosis of pituitary tumor cells. -target gene hsa-mir-133a Colorectal Carcinoma 28748780 miR-133a-3p Targets SUMO-Specific Protease 1 to Inhibit Cell Proliferation and Cell Cycle Progress in Colorectal Cancer. -target gene hsa-mir-429 Glioblastoma 28749077 MiR-429 suppresses glioblastoma multiforme by targeting SOX2. -target gene hsa-mir-1254 "Carcinoma, Lung, Non-Small-Cell" 28749936 MiR-1254 suppresses HO-1 expression through seed region-dependent silencing and non-seed interaction with TFAP2A transcript to attenuate NSCLC growth. -target gene hsa-mir-195 Lung Neoplasms 28752530 "HMGA2 regulation by microRNA-195 (miR-195) was validated by real time-PCR, Western blotting, and luciferase reporter assays" -target gene hsa-mir-155 Marek Disease 28757026 Marek's disease virus type 1 encoded analog of miR-155 promotes proliferation of chicken embryo fibroblast and DF-1 cells by targeting hnRNPAB. -target gene hsa-mir-137 Melanoma 28757416 "The tumour suppressor, miR-137, inhibits malignant melanoma migration by targetting the TBX3 transcription factor." -target gene hsa-mir-21 Cardio-Renal Syndrome 28760335 "MicroRNA-21 regulates peroxisome proliferator-activated receptor alpha, a molecular mechanism of cardiac pathology in Cardiorenal Syndrome Type 4." -target gene hsa-mir-143 "Carcinoma, Hepatocellular" 28765889 Downregulation of microRNA-143 promotes cell proliferation by regulating PKC¦Å in hepatocellular carcinoma cells. -target gene hsa-mir-206 Encephalitis 28765968 Downregulation of CCL2 induced by the upregulation of microRNA-206 is associated with the severity of HEV71 encephalitis -target gene hsa-mir-182 Colorectal Carcinoma 28767179 Upregulation of microRNA-135b and microRNA-182 promotes chemoresistance of colorectal cancer by targeting ST6GALNAC2 via PI3K/AKT pathway. -target gene hsa-mir-132 Melanoma 28767374 "hsa-mir-132,downregulates expression levels of p120RasGAP" -target gene hsa-mir-144 Preeclampsia 28772212 "miR-144 may regulate the proliferation, migration and invasion of trophoblastic cells through targeting PTEN in preeclampsia." -target gene hsa-mir-524 Glioma 28778566 EGFR/c-myc axis regulates TGF¦Â/Hippo/Notch pathway via epigenetic silencing miR-524 in gliomas. -target gene hsa-mir-203 "Carcinoma, Hepatocellular" 28781949 miR-203a-3p.1 targets IL-24 to modulate hepatocellular carcinoma cell growth and metastasis. -target gene hsa-mir-18a Muscle Atrophy 28782600 miR-18a induces myotubes atrophy by down-regulating IgfI. -target gene hsa-mir-124 Glioma 28791348 MicroRNA-124 inhibits the proliferation of C6 glioma cells by targeting Smad4. -target gene hsa-mir-195 "Carcinoma, Laryngeal" 28791411 MicroRNA-195 inhibits growth and invasion of laryngeal carcinoma cells by directly targeting DCUN1D1. -target gene hsa-mir-133a Vascular Hypertrophy 28795305 microRNA-133a attenuates cardiomyocyte hypertrophy by targeting PKC¦Ä and Gq. -target gene hsa-mir-3144 Arrhythmia 28796037 miR-3144-5p overexpression plays a role in HCMs by regulating these genes and TF -target gene hsa-mir-4262 "Carcinoma, Cervical" 28800784 Upregulation of MicroRNA-4262 Targets Kaiso (ZBTB33) to Inhibit the Proliferation and EMT of Cervical Cancer Cells. -target gene hsa-mir-449a "Carcinoma, Lung, Non-Small-Cell" 28800787 MiR-449a Suppresses LDHA-Mediated Glycolysis to Enhance the Sensitivity of Non-Small Cell Lung Cancer Cells to Ionizing Radiation. -target gene hsa-mir-204 Cervical Neoplasms 28800788 MiR-204 Regulates Cell Proliferation and Invasion by Targeting EphB2 in Human Cervical Cancer -target gene hsa-mir-641 Lung Neoplasms 28800790 miR-641 Functions as a Tumor Suppressor by Targeting MDM2 in Human Lung Cancer. -target gene hsa-mir-154 Gastric Neoplasms 28800791 MicroRNA-154 Inhibits the Growth and Invasion of Gastric Cancer Cells by Targeting DIXDC1/WNT Signaling. -target gene hsa-mir-145 Colorectal Carcinoma 28802228 MTDH and MAP3K1 are direct targets of apoptosis-regulating miRNAs in colorectal carcinoma -target gene hsa-mir-375 Colorectal Carcinoma 28802228 MTDH and MAP3K1 are direct targets of apoptosis-regulating miRNAs in colorectal carcinoma -target gene hsa-mir-181c Lung Neoplasms 28806967 MicroRNA-181c inhibits cigarette smoke-induced chronic obstructive pulmonary disease by regulating CCN1 expression. -target gene hsa-mir-21 Kidney Diseases [unspecific] 28808068 Overexpression of renal Smad7 protects against hypertensive nephropathy by inactivating angiotensin II-induced TGF-¦Â/Smad3 and NF-¦ÊB pathways and by targeting the Smad3-dependent microRNA-21 axis -target gene hsa-mir-375 "Squamous Cell Carcinoma, Oral" 28810236 MicroRNA-375 Inhibits Growth and Enhances Radiosensitivity in Oral Squamous Cell Carcinoma by Targeting Insulin Like Growth Factor 1 Receptor. -target gene hsa-mir-9 Melanoma 28810544 MicroRNA-9 inhibits the proliferation and migration of malignant melanoma cells via targeting sirituin 1. -target gene hsa-mir-152 Osteosarcoma 28810933 MicroRNA-152 Suppresses Human Osteosarcoma Cell Proliferation and Invasion by Targeting E2F Transcription Factor 3. -target gene hsa-mir-21 Myocardial Infarction 28817807 Mir-21 Promotes Cardiac Fibrosis After Myocardial Infarction Via Targeting Smad7. -target gene hsa-mir-200a Neoplasms [unspecific] 28817830 MicroRNA-200a Inhibits Transforming Growth Factor ¦Â1-Induced Proximal Tubular Epithelial-Mesenchymal Transition by Targeting ¦Â-Catenin. -target gene hsa-mir-21 Atherosclerosis 28823833 MicroRNA-21 suppresses ox-LDL-induced human aortic endothelial cells injuries in atherosclerosis through enhancement of autophagic flux: Involvement in promotion of lysosomal function. -target gene hsa-mir-124 Gastric Neoplasms 28829503 MicroRNA-124 inhibits cell invasion and epithelial-mesenchymal transition by directly repressing Snail2 in gastric cancer -target gene hsa-mir-200c Breast Neoplasms 28829888 MiR-200c inhibits metastasis of breast tumor via the downregulation of Foxf2. -target gene hsa-mir-367 Melanoma 28829890 miR-367 promotes uveal melanoma cell proliferation and migration by regulating PTEN. -target gene hsa-mir-130a Gastric Neoplasms 28831264 microRNA-130a is an oncomir suppressing the expression of CRMP4 in gastric cancer -target gene hsa-mir-31 "Adenocarcinoma, Gastric" 28836853 MicroRNA-31 inhibits RhoA-mediated tumor invasion and chemotherapy resistance in MKN-45 gastric adenocarcinoma cells. -target gene hsa-mir-204 Hypertension 28839162 MicroRNA-204 promotes vascular endoplasmic reticulum stress and endothelial dysfunction by targeting Sirtuin1. -target gene hsa-mir-494 Ischemia-Reperfusion Injury 28842516 miR-494 up-regulates the PI3K/Akt pathway via targetting PTEN and attenuates hepatic ischemia/reperfusion injury in a rat model. -target gene hsa-mir-22 Arteriosclerosis Obliterans 28848136 Our results indicate that miR-22-3p is a key molecule in regulating HASMC proliferation and migration by targeting HMGB1 and that miR-22-3p and HMGB1 may be therapeutic targets in the treatment of human ASO. -target gene hsa-mir-15a "Carcinoma, Renal Cell" 28849086 Downregulation of microRNA-15a suppresses the proliferation and invasion of renal cell carcinoma via direct targeting of eIF4E. -target gene hsa-mir-130a Colorectal Carcinoma 28849155 MicroRNA-130a is upregulated in colorectal cancer and promotes cell growth and motility by directly targeting forkhead box F2. -target gene hsa-mir-182 Atherosclerosis 28855441 MicroRNA-182 Promotes Lipoprotein Lipase Expression and Atherogenesisby Targeting Histone Deacetylase 9 in Apolipoprotein E-Knockout Mice. -target gene hsa-mir-222 Colorectal Carcinoma 28855850 MicroRNA-222 influences migration and invasion through MIA3 in colorectal cancer -target gene hsa-mir-34a Glioma 28859546 MicroRNA-34a induces transdifferentiation of glioma stem cells into vascular endothelial cells by targeting Notch pathway. -target gene hsa-mir-204 Prostate Neoplasms 28861151 microRNA-204 modulates chemosensitivity and apoptosis of prostate cancer cells by targeting zinc-finger E-box-binding homeobox 1 (ZEB1). -target gene hsa-mir-138 "Carcinoma, Renal Cell, Clear-Cell" 28861152 MicroRNA-138 attenuates epithelial-to-mesenchymal transition by targeting SOX4 in clear cell renal cell carcinoma. -target gene hsa-mir-127 Bone Cancer 28866093 MiR-127 and miR-376a act as tumor suppressors by in?vivo targeting of COA1 and PDIA6 in giant cell tumor of bone. -target gene hsa-mir-376a Bone Cancer 28866093 MiR-127 and miR-376a act as tumor suppressors by in?vivo targeting of COA1 and PDIA6 in giant cell tumor of bone. -target gene hsa-mir-107 "Carcinoma, Hepatocellular" 28867541 miR-107-mediated decrease of HMGCS2 indicates poor outcomes and promotes cell migration in hepatocellular carcinoma -target gene hsa-mir-15a Arthritis 28877850 Gabapentin regulates expression of FGF2 and FGFR1 in dorsal root ganglia via microRNA-15a in the arthritis rat model. -target gene hsa-mir-4317 Gastric Neoplasms 28880489 miRNA-4317 suppresses human gastric cancer cell proliferation by targeting ZNF322. -target gene hsa-mir-126 "Carcinoma, Hepatocellular" 28881749 "Effects of microRNA-126 on cell proliferation, apoptosis and tumor angiogenesis via the down-regulating ERK signaling pathway by targeting EGFL7 in hepatocellular carcinoma" -target gene hsa-mir-106b Cholangiocarcinoma 28881782 miR-106b regulates the 5-fluorouracil resistance by targeting Zbtb7a in cholangiocarcinoma -target gene hsa-mir-106a Prostate Neoplasms 28889725 Oncogene miR-106a promotes proliferation and metastasis of prostate cancer cells by directly targeting PTEN in vivo and in vitro. -target gene hsa-mir-150 Lung Neoplasms 28891208 Serum MicroRNA-150 Predicts Prognosis for Early-Stage Non-Small Cell Lung Cancer and Promotes Tumor Cell Proliferation by Targeting Tumor Suppressor Gene SRCIN1. -target gene hsa-mir-96 hepatocellular carcinoma 28892647 "miR-96 targets SOX6 and promotes proliferation, migration, and invasion of hepatocellular carcinoma" -target gene hsa-mir-34a "Fatty Liver, Non-Alcoholic" 28899784 MiR-181b regulates steatosis in nonalcoholic fatty liver disease via targeting SIRT1. -target gene hsa-mir-149 "Carcinoma, Renal Cell" 28902136 Dual Strands of Pre-miR-149 Inhibit Cancer Cell Migration and Invasion through Targeting FOXM1 in Renal Cell Carcinoma. -target gene hsa-mir-217 Colorectal Carcinoma 28905214 "miR-217-5p induces apoptosis by directly targeting PRKCI, BAG3, ITGAV and MAPK1 in colorectal cancer cells." -target gene hsa-mir-16 Cholangiocarcinoma 28915618 Suppression of miR-16 promotes tumor growth and metastasis through reversely regulating YAP1 in human cholangiocarcinoma. -target gene hsa-mir-25 Neoplasms [unspecific] 28920955 miR-25/93 mediates hypoxia-induced immunosuppression by repressing cGAS. -target gene hsa-mir-21 Rectal Neoplasms 28927090 Downregulation of PDCD4 by miR-21 suppresses tumor transformation and proliferation in a nude mouse renal cancer model. -target gene hsa-mir-181a "Carcinoma, Hepatocellular" 28930552 MicroRNA-181a inhibits autophagy by targeting Atg5 in hepatocellular carcinoma -target gene hsa-mir-181a "Squamous Cell Carcinoma, Skin or Unspecific" 28931048 miR-181a decelerates proliferation in cutaneous squamous cell carcinoma by targeting the proto-oncogene KRAS. -target gene hsa-mir-200c Breast Neoplasms 28933253 The role of p53-microRNA 200-Moesin axis in invasion and drug resistance of breast cancer cells. -target gene hsa-mir-320 Glioma 28934982 MiR-320 inhibits the growth of glioma cells through downregulating PBX3. -target gene hsa-mir-21 Breast Neoplasms 28935174 TIMP-3 mRNA expression levels positively correlates with levels of miR-21 in in situ BC and negatively in PR positive invasive BC. -target gene hsa-mir-130a Neoplasms [unspecific] 28935812 miR-130a Deregulates PTEN and Stimulates Tumor Growth. -target gene hsa-mir-124 Gastric Neoplasms 28941308 In vivo and in vitro effects of microRNA-124 on human gastric cancer by targeting JAG1 through the Notch signaling pathway. -target gene hsa-mir-126 Diabetic Retinopathy 28943945 MicroRNA-126 inhibits cell viability and invasion in a diabetic retinopathy model via targeting IRS-1. -target gene hsa-mir-26b Breast Neoplasms 28944451 Expression of miRNA-26b-5p and its target TRPS1 is associated with radiation exposure in post-Chernobyl breast cancer. -target gene hsa-mir-181a "Carcinoma, Lung, Non-Small-Cell" 28946554 MiR-181a inhibits non-small cell lung cancer cell proliferation by targeting CDK1. -target gene hsa-mir-21 Leukemia 28947822 "Microenvironment regulates the expression of miR-21 and tumor suppressor genes PTEN, PIAS3 and PDCD4 through ZAP-70 in chronic lymphocytic leukemia." -target gene hsa-mir-125a Osteosarcoma 28950256 MicroRNA-125a Regulates Cell Proliferation Via Directly Targeting E2F2 in Osteosarcoma -target gene hsa-mir-500a Neoplasms [unspecific] 28952053 Cancer-associated genes LIF and PAPPA are possible targets of miR-500a-3p -target gene hsa-mir-214 "Squamous Cell Carcinoma, Esophageal" 28954387 MiR-214 inhibits the proliferation and invasion of esophageal squamous cell carcinoma cells by targeting CDC25B. -target gene hsa-mir-18a Alzheimer Disease 28956815 "hsa-mir-18a, having common key targets in the BARHL1-ESR1 network and AD pathway" -target gene hsa-mir-21 Colorectal Carcinoma 28957811 MicroRNA-21 (Mir-21) Promotes Cell Growth and Invasion by Repressing Tumor Suppressor PTEN in Colorectal Cancer. -target gene hsa-mir-138 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 28962111 MicroRNA-138 suppresses cell proliferation in laryngeal squamous cell carcinoma via inhibiting EZH2 and PI3K/AKT signaling. -target gene hsa-mir-191 "Diabetes Mellitus, Type 2" 28963693 "MicroRNA-191, acting via the IRS-1/Akt signaling pathway, is involved in the hepatic insulin resistance induced by cigarette smoke extract." -target gene hsa-mir-124 Pulmonary Hypertension 28972001 Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis. -target gene hsa-mir-629 Ovarian Neoplasms 28972400 Knockdown of miR-629 Inhibits Ovarian Cancer Malignant Behaviors by Targeting Testis-Specific Y-Like Protein 5. -target gene hsa-mir-200b "Carcinoma, Breast" 28972876 miR-200b regulates epithelial-mesenchymal transition of chemo-resistant breast cancer cells by targeting FN1. -target gene hsa-mir-26a "Carcinoma, Skin" 28977801 MiR-26a Mediates Ultraviolet B-Induced Apoptosis by Targeting Histone Methyltransferase EZH2 Depending on Myc Expression. -target gene hsa-mir-23b Gastric Neoplasms 28981115 miR-23a/b promote tumor growth and suppress apoptosis by targeting PDCD4 in gastric cancer. -target gene hsa-mir-1 Rhabdomyosarcoma 28981396 miR-133b also knock downed PAX3-FOXO1 -target gene hsa-mir-17 "Adenocarcinoma, Pancreatic Ductal" 28987387 MiR-17-5p enhances pancreatic cancer proliferation by altering cell cycle profiles via disruption of RBL2/E2F4-repressing complexes. -target gene hsa-mir-29a Rheumatoid Arthritis 28987940 MicroRNA-29a inhibits proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes by repressing STAT3. -target gene hsa-mir-205 Gastric Neoplasms 28987942 miR-205 regulation of ICT1 has an oncogenic potential via promoting the migration and invasion of gastric cancer cells. -target gene hsa-mir-206 "Squamous Cell Carcinoma, Head and Neck" 28987947 MiR-206 inhibits Head and neck squamous cell carcinoma cell progression by targeting HDAC6 via PTEN/AKT/mTOR pathway. -target gene hsa-mir-205 Colorectal Carcinoma 28990808 MicroRNA-205 Mediates Proteinase-Activated Receptor 2 (PAR2) -Promoted Cancer Cell Migration. -target gene hsa-mir-16 Melanoma 28991221 TYRP1-dependent miR-16 sequestration can also be overcome in vivo by using small oligonucleotides that mask miR-16-binding sites on TYRP1 mRNA -target gene hsa-mir-7 Brain Neoplasms 29016934 microRNA-7 upregulates death receptor 5 and primes resistant brain tumors to caspase-mediated apoptosis. -target gene hsa-mir-210 Pheochromocytoma 29018330 MicroRNA-210 Protects PC-12 Cells Against Hypoxia-Induced Injury by Targeting BNIP3. -target gene hsa-mir-34a Liver Diseases [unspecific] 29018509 These findings indicate a circRNA_0046367/miR-34a/PPAR¦Á regulatory system underlying hepatic steatosis -target gene hsa-mir-34a Preeclampsia 29022890 Elevated microRNA-34a contributes to trophoblast cell apoptosis in preeclampsia by targeting BCL-2. -target gene hsa-mir-150 Thyroid Neoplasms 29023429 MiR-150 Inhibits Cell Growth In Vitro and In Vivo by Restraining the RAB11A/WNT/¦Â-Catenin Pathway in Thyroid Cancer. -target gene hsa-mir-29a Neurilemmoma 29023945 MicroRNA-29a inhibits proliferation and motility of schwannoma cells by targeting CDK6. -target gene hsa-mir-29c Neurilemmoma 29023945 MicroRNA-29a inhibits proliferation and motility of schwannoma cells by targeting CDK6. -target gene hsa-mir-1 Diabetic Cardiomyopathies 29024600 Liver X receptor ¦Á is targeted by microRNA-1 to inhibit cardiomyocyte apoptosis through a ROS-mediated mitochondrial pathway. -target gene hsa-mir-373 "Carcinoma, Lung, Non-Small-Cell" 29025258 MicroRNA-373 Inhibits Cell Proliferation and Invasion via Targeting BRF2 in Human Non-small Cell Lung Cancer A549 Cell Line. -target gene hsa-mir-124 "Carcinoma, Lung, Non-Small-Cell" 29039564 Evaluation of microRNA-203 in bone metastasis of patients with non-small cell lung cancer through TGF-¦Â/SMAD2 expression. -target gene hsa-mir-124 Melanoma 29042947 "miR-124 inhibits proliferation, migration and invasion of malignant melanoma cells via targeting versican." -target gene hsa-mir-138 Osteosarcoma 29042962 MicroRNA-138 directly targets TNFAIP8 and acts as a tumor suppressor in osteosarcoma. -target gene hsa-mir-17 Endometriosis 29042983 MicroRNA-17 downregulates expression of the PTEN gene to promote the occurrence and development of adenomyosis. -target gene hsa-mir-29b Ovarian Neoplasms 29050034 Mir-29b Regulates Oxidative Stress by Targeting SIRT1 in Ovarian Cancer Cells. -target gene hsa-let-7a "Carcinoma, Thyroid, Papillary" 29050238 "Let-7a inhibits migration, invasion and tumor growth by targeting AKT2 in papillary thyroid carcinoma." -target gene hsa-mir-574 Spinal Chordoma 29051990 Clinicopathologic implications of CD8+/Foxp3+ ratio and miR-574-3p/PD-L1 axis in spinal chordoma patients. -target gene hsa-mir-767 Melanoma 29054757 MiR-767 promoted cell proliferation in human melanoma by suppressing CYLD expression. -target gene hsa-mir-145 Stroke 29057271 Overexpression of MicroRNA-145 Ameliorates Astrocyte Injury by Targeting Aquaporin 4 in Cerebral Ischemic Stroke -target gene hsa-mir-302a Periodontitis 29058810 miR-302a-3p regulates RANKL expression in human mandibular osteoblast-like cells. -target gene hsa-mir-181a "Carcinoma, Renal Cell, Clear-Cell" 29066014 "Up-regulation of miR-181a in clear cell renal cell carcinoma is associated with lower KLF6 expression, enhanced cell proliferation, accelerated cell cycle transition, and diminished apoptosis." -target gene hsa-mir-155 Neoplasms [unspecific] 29066622 MicroRNA-155 induction via TNF-¦Á and IFN-¦Ã suppresses expression of programmed death ligand-1 (PD-L1) in human primary cells. -target gene hsa-mir-148a "Squamous Cell Carcinoma, Esophageal" 29067119 MiR-148a modulates HLA-G expression and influences tumor apoptosis in esophageal squamous cell carcinoma. -target gene hsa-mir-21 "Lymphoma, Large B-Cell, Diffuse" 29067124 MicroRNA-21 regulates the viability and apoptosis of diffuse large B-cell lymphoma cells by upregulating B cell lymphoma-2. -target gene hsa-mir-140 Cartilage Disease [unspecific] 29067438 miRNA-140 inhibits C3H10T1/2 mesenchymal stem cell proliferation by targeting CXCL12 during transforming growth factor-¦Â3-induced chondrogenic differentiation. -target gene hsa-mir-489 Colorectal Carcinoma 29071516 MiR-489 suppresses tumor growth and invasion by targeting HDAC7 in colorectal cancer. -target gene hsa-mir-106a Kidney Osteogenic Sarcoma 29072688 MiR-106a-5p inhibits the cell migration and invasion of renal cell carcinoma through targeting PAK5. -target gene hsa-mir-1 Hypertrophy 29073097 Content of mitochondrial calcium uniporter (MCU) in cardiomyocytes is regulated by microRNA-1 in physiologic and pathologic hypertrophy. -target gene hsa-mir-30a "Carcinoma, Renal Cell" 29073630 MicroRNA-30a-5p Inhibits the Growth of Renal Cell Carcinoma by Modulating GRP78 Expression. -target gene hsa-mir-107 Cervical Neoplasms 29073938 "Musashi-2, a novel oncoprotein promoting cervical cancer cell growth and invasion, is negatively regulated by p53-induced miR-143 and miR-107 activation." -target gene hsa-mir-143 Cervical Neoplasms 29073938 "Musashi-2, a novel oncoprotein promoting cervical cancer cell growth and invasion, is negatively regulated by p53-induced miR-143 and miR-107 activation." -target gene hsa-mir-146a Inflammation 29074132 "MicroRNA-146a promotes red spotted grouper nervous necrosis virus (RGNNV) replication by targeting TRAF6 in orange spotted grouper, Epinephelus coioides." -target gene hsa-mir-204 Melanoma 29075789 BANCR contributes to the growth and invasion of melanoma by functioning as a competing endogenous RNA to upregulate Notch2 expression by sponging miR?204. -target gene hsa-mir-223 "Carcinoma, Ovarian, Serous" 29079174 miR-223 potentially targets SWI/SNF complex protein SMARCD1 in atypical proliferative serous tumor and high-grade ovarian serous carcinoma. -target gene hsa-mir-200c "Carcinoma, Endometrial" 29080395 MicroRNA-200c Inhibits Epithelial-Mesenchymal Transition by Targeting the BMI-1 Gene Through the Phospho-AKT Pathway in Endometrial Carcinoma Cells In Vitro. -target gene hsa-let-7d Parkinson Disease 29082467 Let-7d microRNA Attenuates 6-OHDA-Induced Injury by Targeting Caspase-3 in MN9D Cells. -target gene hsa-mir-21 Lung Fibrosis 29084974 Mir-21 Mediates the Inhibitory Effect of Ang (1-7) on AngII-induced NLRP3 Inflammasome Activation by Targeting Spry1 in lung fibroblasts. -target gene hsa-mir-106b Retinoblastoma 29085029 HBeAg-induced miR-106b promotes cell growth by targeting the retinoblastoma gene. -target gene hsa-mir-21 Rectal Neoplasms 29085468 miR-21 inhibition of LATS1 promotes proliferation and metastasis of renal cancer cells and tumor stem cell phenotype. -target gene hsa-mir-27a Polycystic Ovarian Syndrome 29089199 MicroRNA-27a-3p affects estradiol and androgen imbalance by targeting Creb1 in the granulosa cells in mouse polycytic ovary syndrome model. -target gene hsa-mir-491 Neoplasms [unspecific] 29091292 Functional SNP in microRNA-491-5p binding site of MMP9 3'-UTR affects cancer susceptibility. -target gene hsa-mir-613 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 29091303 MiR-613 suppressed the laryngeal squamous cell carcinoma progression through regulating PDK1. -target gene hsa-mir-150 Cervical Neoplasms 29091902 "MicroRNA-150 promotes cell proliferation, migration, and invasion of cervical cancer through targeting PDCD4." -target gene hsa-mir-34a "Squamous Cell Carcinoma, Esophageal" 29094237 MicroRNA-34a suppresses invasion and metastatic in esophageal squamous cell carcinoma by regulating CD44. -target gene hsa-mir-137 Melanoma 29097210 miR-137 inhibits glutamine catabolism and growth of malignant melanoma by targeting glutaminase. -target gene hsa-mir-130a Cervical Neoplasms 29099271 SOX9/miR-130a/CTR1 axis modulates DDP-resistance of cervical cancer cell. -target gene hsa-mir-21 "Leukemia, Myeloid, Acute" 29100302 A tyrosine kinase-STAT5-miR21-PDCD4 regulatory axis in chronic and acute myeloid leukemia cells. -target gene hsa-mir-30a Diabetic Cataract 29100392 MiR-30a inhibits BECN1-mediated autophagy in diabetic cataract. -target gene hsa-mir-27a Diabetes Mellitus 29100869 Oxidative stress-induced miR-27a targets the redox gene nuclear factor erythroid 2-related factor 2 in diabetic embryopathy. -target gene hsa-mir-21 Gastric Neoplasms 29101039 miR-21 modulates prostaglandin signaling and promotes gastric tumorigenesis by targeting 15-PGDH. -target gene hsa-mir-27a "Fatty Liver, Non-Alcoholic" 29101357 MicroRNA-27a regulates hepatic lipid metabolism and alleviates NAFLD via repressing FAS and SCD1. -target gene hsa-mir-4326 Lung Neoplasms 29101731 miR-4326 promotes lung cancer cell proliferation through targeting tumor suppressor APC2. -target gene hsa-mir-146a Asthma 29101850 MicroRNA-146a promotes IgE class switch in B cells via upregulating 14-3-3¦Ò expression. -target gene hsa-mir-155 Colon Neoplasms 29104623 "MicroRNA-155 regulates the proliferation, cell cycle, apoptosis and migration of colon cancer cells and targets CBL." -target gene hsa-mir-150 "Fatty Liver, Non-Alcoholic" 29107687 MiR-150 deficiency ameliorated hepatosteatosis and insulin resistance in nonalcoholic fatty liver disease via targeting CASP8 and FADD-like apoptosis regulator. -target gene hsa-mir-30a "Carcinoma, Hepatocellular" 29108194 MicroRNA-30a inhibits proliferation of hepatocellular carcinoma cells via targeted regulation of forkhead-box protein A1. -target gene hsa-mir-10a Lupus Nephritis 29109423 Transcriptomic profiling in human mesangial cells using patient-derived lupus autoantibodies identified miR-10a as a potential regulator of IL8. -target gene hsa-mir-223 Hypertrophy 29110214 SOX2-mediated inhibition of miR-223 contributes to STIM1 activation in phenylephrine-induced hypertrophic cardiomyocytes. -target gene hsa-mir-107 "Adenocarcinoma, Pancreatic Ductal" 29111166 Deregulated expression of miR-107 inhibits metastasis of PDAC through inhibition PI3K/Akt signaling via caveolin-1 and PTEN. -target gene hsa-mir-181b Gastric Neoplasms 29113265 The present study confirmed that CDX2 was suppressed by activation of the IL-6/STAT3 signaling pathway via miR-181b in vitro -target gene hsa-mir-488 Ovarian Neoplasms 29113360 microRNA-488 inhibits chemoresistance of ovarian cancer cells by targeting Six1 and mitochondrial function. -target gene hsa-mir-222 "Carcinoma, Nasopharyngeal" 29115464 microRNA-222 promotes tumor growth and confers radioresistance in nasopharyngeal carcinoma by targeting PTEN. -target gene hsa-mir-200c Endometriosis 29116025 miR-200c suppresses endometriosis by targeting MALAT1 in vitro and in vivo. -target gene hsa-mir-449a Osteosarcoma 29117539 Hsa_circ_0009910 promotes carcinogenesis by promoting the expression of miR-449a target IL6R in osteosarcoma. -target gene hsa-mir-21 Rectal Neoplasms 29131259 MicroRNA-21 functions as an oncogene and promotes cell proliferation and invasion via TIMP3 in renal cancer. -target gene hsa-mir-155 Viral Myocarditis 29136142 The forkhead transcription factor Foxo3 negatively regulates natural killer cell function and viral clearance in myocarditis. -target gene hsa-mir-143 "Squamous Cell Carcinoma, Esophageal" 29137232 "Integration of metabolomics, transcriptomics, and microRNA expression profiling reveals a miR-143-HK2-glucose network underlying zinc-deficiency-associated esophageal neoplasia." -target gene hsa-let-7d "Adenocarcinoma, Pancreatic Ductal" 29137251 selinexor induced the expression of two important tumor suppressive miRNAs miR-34c and let-7d leading to the up-regulation of p21WAF1 -target gene hsa-mir-34c "Adenocarcinoma, Pancreatic Ductal" 29137251 selinexor induced the expression of two important tumor suppressive miRNAs miR-34c and let-7d leading to the up-regulation of p21WAF1 -target gene hsa-mir-200c Gastric Neoplasms 29138864 Expression level of microRNA-200c is associated with cell morphology in vitro and histological differentiation through regulation of ZEB1/2 and E-cadherin in gastric carcinoma. -target gene hsa-mir-23a "Carcinoma, Pancreatic" 29141872 miR-23a acts as an oncogene in pancreatic carcinoma by targeting FOXP2. -target gene hsa-mir-24 Osteoarthritis 29143973 "Effects of microRNA-24 targeting C-myc on apoptosis, proliferation and cytokine expressions in chondrocytes of rats with osteoarthritis via MAPK signaling pathway." -target gene hsa-mir-27a "Carcinoma, Hepatocellular" 29143999 MicroRNA-27a-3p inhibits cell viability and migration through down-regulating DUSP16 in hepatocellular carcinoma. -target gene hsa-mir-146a Ankylosing Spondylitis 29145150 MicroRNA-146a knockdown suppresses the progression of ankylosing spondylitis by targeting dickkopf 1 -target gene hsa-mir-34b Acute Lung Injury 29150939 miR-34b-5p inhibition attenuates lung inflammation and apoptosis in an LPS-induced acute lung injury mouse model by targeting progranulin. -target gene hsa-mir-205 "Squamous Cell Carcinoma, Oral" 29150940 Tumor-suppressive roles of ¦¤Np63¦Â-miR-205 axis in epithelial-mesenchymal transition of oral squamous cell carcinoma via targeting ZEB1 and ZEB2 -target gene hsa-mir-200c Neuropathic Pain 29150958 Inhibition of miR-200b/miR-429 contributes to neuropathic pain development through targeting zinc finger E box binding protein-1. -target gene hsa-mir-429 Neuropathic Pain 29150958 Inhibition of miR-200b/miR-429 contributes to neuropathic pain development through targeting zinc finger E box binding protein-1. -target gene hsa-mir-31 "Carcinoma, Hepatocellular" 29152108 MicroRNA-31 suppresses the self-renewal capability of ¦Á2¦Ä1+ liver tumor-initiating cells by targeting ISL1 -target gene hsa-mir-27a Liver Injury 29156532 paclitaxel significantly attenuated septic induced liver injury through reducing inflammatory response via miR-27a/TAB3/NF-¦ÊB signaling pathway -target gene hsa-mir-31 Cervical Neoplasms 29159179 miR-31 Functions as an Oncomir Which Promotes Epithelial-Mesenchymal Transition via Regulating BAP1 in Cervical Cancer -target gene hsa-mir-145 Neuropathic Pain 29162479 MiR-145 ameliorates neuropathic pain via inhibiting inflammatory responses and mTOR signaling pathway by targeting Akt3 in a rat model. -target gene hsa-mir-20b Prostate Neoplasms 29163708 miR-20b promotes cellular proliferation and migration by directly regulating phosphatase and tensin homolog in prostate cancer -target gene hsa-mir-34a Congenital Heart Diseases 29175286 miR-34a increases the risk of CHD through its downregulation of NOTCH-1 by modulating the Notch signaling pathway -target gene hsa-mir-23a "Carcinoma, Hepatocellular" 29176948 The Oncogenic Role of Tribbles 1 in Hepatocellular Carcinoma Is Mediated by a Feedback Loop Involving microRNA-23a and p53 -target gene hsa-mir-21 Cervical Neoplasms 29177591 "MicroRNA-21 promotes proliferation, migration, and invasion of cervical cancer through targeting TIMP3" -target gene hsa-mir-326 Multiple Sclerosis 29181619 MicroRNA-326 contributes to autoimmune thyroiditis by targeting the Ets-1 protein -target gene hsa-mir-122 Chronic Hepatitis C 29182758 miR-122 regulates ALDOB and PKM2 expression at the mRNA level -target gene hsa-mir-146a Osteoarthritis 29183039 MiR-146a Aggravates LPS-Induced Inflammatory Injury by Targeting CXCR4 in the Articular Chondrocytes -target gene hsa-mir-519d "Carcinoma, Breast" 29188531 MiR-519d-3p suppresses breast cancer cell growth and motility via targeting LIM domain kinase 1. -target gene hsa-mir-34a "Squamous Cell Carcinoma, Esophageal" 29190930 MicroRNA-34a functions as a tumor suppressor by directly targeting oncogenic PLCE1 in Kazakh esophageal squamous cell carcinoma -target gene hsa-mir-361 Obesity 29191698 MicroRNAs-361-5p and miR-574-5p associate with human adipose morphology and regulate EBF1 expression in white adipose tissue. -target gene hsa-mir-574 Obesity 29191698 MicroRNAs-361-5p and miR-574-5p associate with human adipose morphology and regulate EBF1 expression in white adipose tissue. -target gene hsa-mir-19a Multiple Myeloma 29201171 the results of the present study indicate that targets genes of miR-19a are potential candidate biomarkers for MM -target gene hsa-mir-513a Lung Neoplasms 29204818 Mir-513a-3p contributes to the controlling of cellular migration processes in the A549 lung tumor cells by modulating integrin ¦Â-8 expression. -target gene hsa-mir-6869 Colorectal Carcinoma 29206292 MicroRNA-6869-5p acts as a tumor suppressor via targeting TLR4/NF-¦ÊB signaling pathway in colorectal cancer. -target gene hsa-mir-26a Osteoarthritis 29208566 miR-26a/-26b/FUT4/NF-¦ÊB axis may serve as a predictive biomarker and a potential therapeutic target in OA treatment -target gene hsa-mir-1202 "Carcinoma, Hepatocellular" 29217161 MiR-1202 suppresses hepatocellular carcinoma cells migration and invasion by targeting cyclin dependent kinase 14 -target gene hsa-mir-200a "Carcinoma, Breast, Triple Negative" 29217458 The identified IMP2/3-miR-200a-PR axis represents a novel double-negative feedback loop and serves as a new potential therapeutic target for the treatment of TNBC -target gene hsa-mir-200c Lung Neoplasms 29219949 A miRNA-200c/cathepsin L feedback loop determines paclitaxel resistance in human lung cancer A549 cells in vitro through regulating epithelial-mesenchymal transition. -target gene hsa-mir-210 Glioblastoma 29226333 "p53 and miR-210 regulated NeuroD2, a neuronal basic helix-loop-helix transcription factor, is downregulated in glioblastoma patients and functions as a tumor suppressor under hypoxic microenvironment" -target gene hsa-mir-182 Atherosclerosis 29226948 MiR-182-5p inhibited oxidative stress and apoptosis triggered by oxidized low-density lipoprotein via targeting toll-like receptor 4. -target gene hsa-mir-29c Hyperlipidemia 29226968 Study of microRNAs targeted Dvl2 on the osteoblasts differentiation of rat BMSCs in hyperlipidemia environment. -target gene hsa-mir-155 Kidney Neoplasms 29228417 "Inhibition of miR-155 increased GSK-3¦Â expression, attenuated Wnt/¦Â-catenin signaling pathway, weakened proliferation and invasion, and facilitated apoptosis in renal carcinoma cells" -target gene hsa-mir-21 Glioblastoma 29228449 miR-21 enhances the resistance of human glioma cells to BCNU by decreasing the expression of Spry2 protein -target gene hsa-mir-21 Glioma 29228450 MiR-21 enhanced glioma cells resistance to carmustine via decreasing Spry2 expression -target gene hsa-mir-143 Melanoma 29230879 "These results support a functional role for miR-143-5p in regulating alpaca melanocyte migration, proliferation and melanogenesis through direct targeting of TAK1" -target gene hsa-mir-150 "Squamous Cell Carcinoma, Head and Neck" 29233721 Antitumor miR-150-5p and miR-150-3p inhibit cancer cell aggressiveness by targeting SPOCK1 in head and neck squamous cell carcinoma. -target gene hsa-mir-124 Gastric Neoplasms 29234151 "SRGAP1, a crucial target of miR-340 and miR-124, functions as a potential oncogene in gastric tumorigenesis" -target gene hsa-mir-340 Gastric Neoplasms 29234151 "SRGAP1, a crucial target of miR-340 and miR-124, functions as a potential oncogene in gastric tumorigenesis" -target gene hsa-mir-155 "Carcinoma, Hepatocellular" 29234238 miR-155-5p modulates malignant behaviors of hepatocellular carcinoma by directly targeting CTHRC1 and indirectly regulating GSK-3¦Â-involved Wnt/¦Â-catenin signaling -target gene hsa-mir-23b Osteoporosis 29234953 Involvement of microRNA-23b in TNF-¦Á-reduced BMSC osteogenic differentiation via targeting runx2 -target gene hsa-mir-29a Ischemia-Reperfusion Injury 29238305 MiR-29a Suppresses Spermatogenic Cell Apoptosis in Testicular Ischemia-Reperfusion Injury by Targeting TRPV4 Channels -target gene hsa-mir-92a Osteoarthritis 29241192 MiR-92a-3p is an important regulator of ADAMTS-4/5 in human chondrocytes and may contribute to the development of OA -target gene hsa-mir-296 "Carcinoma, Cervical" 29241478 MicroRNA-296 Targets Specificity Protein 1 to Suppress Cell Proliferation and Invasion in Cervical Cancer. -target gene hsa-mir-203 Inflammation 29242191 The inducible microRNA-203 in fish represses the inflammatory responses to Gram-negative bacteria by targeting IL-1 receptor-associated kinase 4 -target gene hsa-mir-185 Cleidocranial Dysplasia 29242628 Mutant Runx2 regulates amelogenesis and osteogenesis through a miR-185-5p-Dlx2 axis. -target gene hsa-mir-24 Atherosclerosis 29250154 MicroRNA-24 inhibits the proliferation and migration of endothelial cells in patients with atherosclerosis by targeting importin-¦Á3 and regulating inflammatory responses -target gene hsa-mir-25 "Squamous Cell Carcinoma, Esophageal" 29250158 "PTEN, TP53, MDM2, E2F1, PRMT5, MCM2, RB1, CDKN1A, SHAD7 and EZH2 may be targeted by the miR-106b-25 cluster, and act together to regulate the development of ESCC" -target gene hsa-mir-21 Liver Cirrhosis 29250171 The miRNA-target regulatory network may provide additional insight into the current data regarding the role of miRNAs in liver cirrhosis -target gene hsa-mir-29a Retinoblastoma 29251322 miR-29a inhibits human retinoblastoma progression by targeting STAT3 -target gene hsa-mir-21 "Carcinoma, Hepatocellular" 29253196 miR-122 participates in the regulation of HCC cell apoptosis through modulating the miR-21-targeted programmed cell death 4 (PDCD4) signal pathway -target gene hsa-mir-140 "Carcinoma, Renal Cell, Clear-Cell" 29253611 "miRNA-429, miRNA-206, and miRNA-184 and their target gene CCND1, as well as miRNA-140-3p and miRNA-142-5p and their target gene ATP1B1, might play key roles in ccRCC progression and could be useful biomarkers during ccRCC development" -target gene hsa-mir-142 "Carcinoma, Renal Cell, Clear-Cell" 29253611 "miRNA-429, miRNA-206, and miRNA-184 and their target gene CCND1, as well as miRNA-140-3p and miRNA-142-5p and their target gene ATP1B1, might play key roles in ccRCC progression and could be useful biomarkers during ccRCC development" -target gene hsa-mir-184 "Carcinoma, Renal Cell, Clear-Cell" 29253611 "miRNA-429, miRNA-206, and miRNA-184 and their target gene CCND1, as well as miRNA-140-3p and miRNA-142-5p and their target gene ATP1B1, might play key roles in ccRCC progression and could be useful biomarkers during ccRCC development" -target gene hsa-mir-206 "Carcinoma, Renal Cell, Clear-Cell" 29253611 "miRNA-429, miRNA-206, and miRNA-184 and their target gene CCND1, as well as miRNA-140-3p and miRNA-142-5p and their target gene ATP1B1, might play key roles in ccRCC progression and could be useful biomarkers during ccRCC development" -target gene hsa-mir-429 "Carcinoma, Renal Cell, Clear-Cell" 29253611 "miRNA-429, miRNA-206, and miRNA-184 and their target gene CCND1, as well as miRNA-140-3p and miRNA-142-5p and their target gene ATP1B1, might play key roles in ccRCC progression and could be useful biomarkers during ccRCC development" -target gene hsa-let-7g Atherosclerosis 29254143 Let-7g suppresses both canonical and non-canonical NF-¦ÊB pathways in macrophages leading to anti-atherosclerosis -target gene hsa-mir-182 Osteosarcoma 29254169 "MicroRNA-182 downregulates Wnt/¦Â-catenin signaling, inhibits proliferation, and promotes apoptosis in human osteosarcoma cells by targeting HOXA9" -target gene hsa-mir-29b Breast Neoplasms 29256222 "MiRNA-29b can inhibit the proliferation, invasion and metastasis of breast cancer cells by inhibiting the expression of RTKN" -target gene hsa-mir-296 Melanoma 29260433 Coordinated targeting of MMP-2/MMP-9 by miR-296-3p/FOXCUT exerts tumor-suppressing effects in choroidal malignant melanoma. -target gene hsa-mir-188 Glioma 29268818 miR-188 Inhibits Glioma Cell Proliferation and Cell Cycle Progression Through Targeting ¦Â-Catenin. -target gene hsa-mir-143 Cervical Neoplasms 29271989 MicroRNA-143 regulates the proliferation and apoptosis of cervical cancer cells by targeting HIF-1¦Á -target gene hsa-mir-181a Thyroid Neoplasms 29271997 MiR-181a promotes growth of thyroid cancer cells by targeting tumor suppressor RB1 -target gene hsa-mir-30e Parkinson Disease 29274035 MicroRNA-30e regulates neuroinflammation in MPTP model of Parkinson's disease by targeting Nlrp3. -target gene hsa-mir-146b Psoriasis 29279330 MicroRNA-146 and cell trauma down-regulate expression of the psoriasis-associated atypical chemokine receptor ACKR2 -target gene hsa-mir-34a Neoplasms [unspecific] 29285066 miR-34a may serve an important role in hyperthermia-regulated apoptosis and proliferation in HCT116 cells by influencing the transcriptional activity of p53 -target gene hsa-mir-34a "Squamous Cell Carcinoma, Skin or Unspecific" 29285100 "MicroRNA-34a directly targets high-mobility group box 1 and inhibits the cancer cell proliferation, migration and invasion in cutaneous squamous cell carcinoma" -target gene hsa-mir-200c "Carcinoma, Gastric" 29286062 "miR-200c regulates the proliferation, apoptosis and invasion of gastric carcinoma cells through the downregulation of EDNRA expression" -target gene hsa-mir-124a Liver Neoplasms 29286137 MicroRNA-124a inhibits cell proliferation and migration in liver cancer by regulating interleukin-11 -target gene hsa-mir-146a Inflammation 29288795 miR-146a inhibits inflammatory cytokine production in B cells through directly targeting IRAK1 -target gene hsa-mir-34a Huntington Disease 29289683 Perturbations in the p53/miR-34a/SIRT1 pathway in the R6/2 Huntington's disease model -target gene hsa-mir-206 "Carcinoma, Ovarian" 29291022 NFE2L2/NRF2 silencing-inducible miR-206 targets c-MET/EGFR and suppresses BCRP/ABCG2 in cancer cells -target gene hsa-mir-346 "Carcinoma, Hepatocellular" 29295726 miR-346 Promotes HCC Progression by Suppressing Breast Cancer Metastasis Suppressor 1 Expression. -target gene hsa-mir-136 "Carcinoma, Hepatocellular" 29295728 miR-136 Inhibits Malignant Progression of Hepatocellular Carcinoma Cells by Targeting Cyclooxygenase 2. -target gene hsa-mir-34a "Carcinoma, Hepatocellular" 29298665 "Our results may lead researchers to understand the molecular mechanism of miR-34a in the diagnosis, prognosis and therapy of HCC" -target gene hsa-mir-34a Cataract 29299142 MicroRNA-34a promotes mitochondrial dysfunction-induced apoptosis in human lens epithelial cells by targeting Notch2 -target gene hsa-mir-19a Osteoarthritis 29306212 MicroRNA-19a promotes cell viability and migration of chondrocytes via up-regulating SOX9 through NF-¦ÊB pathway -target gene hsa-mir-137 Melanoma 29307109 miR-137 inhibits melanoma cell proliferation through downregulation of GLO1 -target gene hsa-mir-373 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 29307338 Expression of miR-373 and its predicted target genes E-cadherin and CD44 in patients with laryngeal squamous cell carcinoma -target gene hsa-mir-34a Osteosarcoma 29312491 MicroRNA-34a promotes cell cycle arrest and apoptosis and suppresses cell adhesion by targeting DUSP1 in osteosarcoma. -target gene hsa-mir-423 "Carcinoma, Hepatocellular" 29312509 MicroRNA-423 enhances the invasiveness of hepatocellular carcinoma via regulation of BRMS1 -target gene hsa-mir-492 Hepatoblastoma 29314711 MiR-492 regulates metastatic properties of hepatoblastoma via CD44 -target gene hsa-mir-26a Inflammation 29315680 "the effect of bta-miR-26a in mastitis, mediated at least in part by enhancing FGA expression, involves host defense, inflammation and tissue damage" -target gene hsa-mir-21 Glioma 29316313 MicroRNA-21 promotes glioma cell proliferation and inhibits senescence and apoptosis by targeting SPRY1 via the PTEN/PI3K/AKT signaling pathway -target gene hsa-mir-22 "Squamous Cell Carcinoma, Oral" 29319163 "MicroRNA-22 suppresses cell proliferation, migration and invasion in oral squamous cell carcinoma by targeting NLRP3." -target gene hsa-mir-125b "Diabetes Mellitus, Type 2" 29319168 Hepatic miR-125b inhibits insulin signaling pathway by targeting PIK3CD. -target gene hsa-mir-143 Gastric Neoplasms 29321084 miR-143 inhibits cell proliferation of gastric cancer cells through targeting GATA6 -target gene hsa-mir-519d "Carcinoma, Cervical" 29321085 MicroRNA-519d-3p Inhibits Proliferation and Promotes Apoptosis by Targeting HIF-2¦Á in Cervical Cancer Under Hypoxic Conditions. -target gene hsa-mir-29a Mitochondrial Metabolism Disease 29322081 Data of expression status of miR-29a and its putative target mitochondrial apoptosis regulatory gene DRP1 upon miR-15a and miR-214 inhibition -target gene hsa-mir-150 Neuropathic Pain 29323698 It was revealed that XIST/miR-150/ZEB1 axis can be provided as a therapeutic target in neuropathic pain -target gene hsa-mir-501 Autosomal Dominant Polycystic Kidney Disease 29323708 MicroRNA501-5p induces p53 proteasome degradation through the activation of the mTOR/MDM2 pathway in ADPKD cells. -target gene hsa-mir-15b Glioma 29323737 MiR-15b/HOTAIR/p53 form a regulatory loop that affects the growth of glioma cells -target gene hsa-mir-145 Atherosclerosis 29324316 MicroRNA-145 alleviates high glucose-induced proliferation and migration of vascular smooth muscle cells through targeting ROCK1 -target gene hsa-mir-21 "Carcinoma, Salivary Adenoid Cystic" 29328455 "miR-21 may promote SACC progression via PDCD4, PTEN and Bcl-2" -target gene hsa-mir-200a Breast Neoplasms 29329575 MicroRNA-200a confers chemoresistance by antagonizing TP53INP1 and YAP1 in human breast cancer -target gene hsa-mir-195 Heart Failure 29330215 increased levels of miR-195 in failing myocardium regulate a novel pathway that involves direct SIRT3 suppression and enzymatic inhibition via increased acetylation of PDH and ATP synthase that are essential for cardiac energy metabolism -target gene hsa-mir-301a Prostate Neoplasms 29331421 Hyperglycaemia-induced miR-301a promotes cell proliferation by repressing p21 and Smad4 in prostate cancer. -target gene hsa-mir-494 Diabetes Mellitus 29333131 miR-494 protects pancreatic ¦Â-cell function by targeting PTEN in gestational diabetes mellitus -target gene hsa-mir-155 Melanoma 29333944 MiR-155 Promotes Uveal Melanoma Cell Proliferation and Invasion by Regulating NDFIP1 Expression -target gene hsa-mir-21 Asthma 29334241 Disordered expression of genes under the regulation of miRNAs may play an important role in CARAS -target gene hsa-mir-21 Autism Spectrum Disorder 29334241 Disordered expression of genes under the regulation of miRNAs may play an important role in CARAS -target gene hsa-mir-92a Asthma 29334241 Disordered expression of genes under the regulation of miRNAs may play an important role in CARAS -target gene hsa-mir-92a Autism Spectrum Disorder 29334241 Disordered expression of genes under the regulation of miRNAs may play an important role in CARAS -target gene hsa-mir-93 Asthma 29334241 Disordered expression of genes under the regulation of miRNAs may play an important role in CARAS -target gene hsa-mir-93 Autism Spectrum Disorder 29334241 Disordered expression of genes under the regulation of miRNAs may play an important role in CARAS -target gene hsa-mir-144 Osteoporosis 29334613 Reduced miR-144-3p expression in serum and bone mediates osteoporosis pathogenesis by targeting RANK. -target gene hsa-mir-181a Preeclampsia 29339719 miR-181a-5p suppresses invasion and migration of HTR-8/SVneo cells by directly targeting IGF2BP2. -target gene hsa-mir-19 Glioma 29340016 MiR-19 regulates the proliferation and invasion of glioma by RUNX3 via ¦Â-catenin/Tcf-4 signaling -target gene hsa-mir-34a "Carcinoma, Hepatocellular" 29344126 microRNA-34a overexpression inhibits cell migration and invasion via regulating SIRT1 in hepatocellular carcinoma -target gene hsa-mir-10a "Carcinoma, Thyroid, Follicular" 29344146 "Network analysis indicated a co-regulatory association between miR-296-5p, miR-10a, miR-139-5p, miR-452, miR-493, miR-7, miR-137, miR-144, miR-145 and corresponding targeted mRNAs, including TNF receptor superfamily member 11b, benzodiazepine receptor (peripheral) -associated protein 1, and transforming growth factor ¦Â receptor 2" -target gene hsa-mir-137 "Carcinoma, Thyroid, Follicular" 29344146 "Network analysis indicated a co-regulatory association between miR-296-5p, miR-10a, miR-139-5p, miR-452, miR-493, miR-7, miR-137, miR-144, miR-145 and corresponding targeted mRNAs, including TNF receptor superfamily member 11b, benzodiazepine receptor (peripheral) -associated protein 1, and transforming growth factor ¦Â receptor 2" -target gene hsa-mir-139 "Carcinoma, Thyroid, Follicular" 29344146 "Network analysis indicated a co-regulatory association between miR-296-5p, miR-10a, miR-139-5p, miR-452, miR-493, miR-7, miR-137, miR-144, miR-145 and corresponding targeted mRNAs, including TNF receptor superfamily member 11b, benzodiazepine receptor (peripheral) -associated protein 1, and transforming growth factor ¦Â receptor 2" -target gene hsa-mir-144 "Carcinoma, Thyroid, Follicular" 29344146 "Network analysis indicated a co-regulatory association between miR-296-5p, miR-10a, miR-139-5p, miR-452, miR-493, miR-7, miR-137, miR-144, miR-145 and corresponding targeted mRNAs, including TNF receptor superfamily member 11b, benzodiazepine receptor (peripheral) -associated protein 1, and transforming growth factor ¦Â receptor 2" -target gene hsa-mir-145 "Carcinoma, Thyroid, Follicular" 29344146 "Network analysis indicated a co-regulatory association between miR-296-5p, miR-10a, miR-139-5p, miR-452, miR-493, miR-7, miR-137, miR-144, miR-145 and corresponding targeted mRNAs, including TNF receptor superfamily member 11b, benzodiazepine receptor (peripheral) -associated protein 1, and transforming growth factor ¦Â receptor 2" -target gene hsa-mir-296 "Carcinoma, Thyroid, Follicular" 29344146 "Network analysis indicated a co-regulatory association between miR-296-5p, miR-10a, miR-139-5p, miR-452, miR-493, miR-7, miR-137, miR-144, miR-145 and corresponding targeted mRNAs, including TNF receptor superfamily member 11b, benzodiazepine receptor (peripheral) -associated protein 1, and transforming growth factor ¦Â receptor 2" -target gene hsa-mir-452 "Carcinoma, Thyroid, Follicular" 29344146 "Network analysis indicated a co-regulatory association between miR-296-5p, miR-10a, miR-139-5p, miR-452, miR-493, miR-7, miR-137, miR-144, miR-145 and corresponding targeted mRNAs, including TNF receptor superfamily member 11b, benzodiazepine receptor (peripheral) -associated protein 1, and transforming growth factor ¦Â receptor 2" -target gene hsa-mir-493 "Carcinoma, Thyroid, Follicular" 29344146 "Network analysis indicated a co-regulatory association between miR-296-5p, miR-10a, miR-139-5p, miR-452, miR-493, miR-7, miR-137, miR-144, miR-145 and corresponding targeted mRNAs, including TNF receptor superfamily member 11b, benzodiazepine receptor (peripheral) -associated protein 1, and transforming growth factor ¦Â receptor 2" -target gene hsa-mir-7 "Carcinoma, Thyroid, Follicular" 29344146 "Network analysis indicated a co-regulatory association between miR-296-5p, miR-10a, miR-139-5p, miR-452, miR-493, miR-7, miR-137, miR-144, miR-145 and corresponding targeted mRNAs, including TNF receptor superfamily member 11b, benzodiazepine receptor (peripheral) -associated protein 1, and transforming growth factor ¦Â receptor 2" -target gene hsa-mir-124 Ovarian Neoplasms 29344168 MiR-124 inhibits invasion and induces apoptosis of ovarian cancer cells by targeting programmed cell death 6 -target gene hsa-mir-138 "Carcinoma, Renal Cell" 29344205 MicroRNA-138 suppresses cell proliferation and invasion of renal cell carcinoma by directly targeting SOX9 -target gene hsa-mir-146a "Carcinoma, Lung, Non-Small-Cell" 29344219 Upregulation of miR-146a increases cisplatin sensitivity of the non-small cell lung cancer A549 cell line by targeting JNK-2 -target gene hsa-mir-1827 "Adenocarcinoma, Lung" 29344280 "MiR-378 and MiR-1827 Regulate Tumor Invasion, Migration and Angiogenesis in Human Lung Adenocarcinoma by Targeting RBX1 and CRKL, Respectively" -target gene hsa-mir-378 "Adenocarcinoma, Lung" 29344280 "MiR-378 and MiR-1827 Regulate Tumor Invasion, Migration and Angiogenesis in Human Lung Adenocarcinoma by Targeting RBX1 and CRKL, Respectively" -target gene hsa-let-7b Hypohidrotic Ectodermal Dysplasia 29344666 Let-7b regulates alpaca hair growth by downregulating ectodysplasin A. -target gene hsa-mir-595 "Leukemia, Lymphoblastic, Acute" 29345051 MiR-595 Suppresses the Cellular Uptake and Cytotoxic Effects of Methotrexate by Targeting SLC19A1 in CEM/C1 Cells. -target gene hsa-mir-137 Melanoma 29348676 miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma -target gene hsa-mir-199a Acute Respiratory Distress Syndrome 29351405 Acute downregulation of miR-199a attenuates sepsis-induced acute lung injury by targeting SIRT1 -target gene hsa-mir-182 "Squamous Cell Carcinoma, Head and Neck" 29356167 "there is frequent and concordant upregulation of miR-31, miR-96, and miR-182 during HNSCC and these miRNAs co-target Numb" -target gene hsa-mir-31 "Squamous Cell Carcinoma, Head and Neck" 29356167 "there is frequent and concordant upregulation of miR-31, miR-96, and miR-182 during HNSCC and these miRNAs co-target Numb" -target gene hsa-mir-96 "Squamous Cell Carcinoma, Head and Neck" 29356167 "there is frequent and concordant upregulation of miR-31, miR-96, and miR-182 during HNSCC and these miRNAs co-target Numb" -target gene hsa-mir-16 Pineal Gland Cancer 29359963 Melatonin Inhibits the Proliferation of Gastric Cancer Cells Through Regulating the miR-16-5p-Smad3 Pathway. -target gene hsa-mir-15b Prostate Neoplasms 29363862 miR-15b-5p facilitates the tumorigenicity by targeting RECK and predicts tumour recurrence in prostate cancer -target gene hsa-mir-30c Pediatric Osteosarcoma 29364496 Biological function of microRNA-30c/SOX9 in pediatric osteosarcoma cell growth and metastasis. -target gene hsa-mir-448 Breast Neoplasms 29368542 "miR-448 inhibits cell migration, invasion, and EMT by targeting to the 3'UTR of ZEB1/2" -target gene hsa-mir-330 Alzheimer Disease 29369410 "Protective effects of microRNA-330 on amyloid ¦Â-protein production, oxidative stress, and mitochondrial dysfunction in Alzheimer's disease by targeting VAV1 via the MAPK signaling pathway." -target gene hsa-mir-424 "Carcinoma, Endometrial" 29371986 "MicroRNA-424/E2F6 feedback loop modulates cell invasion, migration and EMT in endometrial carcinoma" -target gene hsa-mir-760 "Carcinoma, Lung, Non-Small-Cell" 29372517 MiR-760 suppresses non-small cell lung cancer proliferation and metastasis by targeting ROS1. -target gene hsa-mir-34a Chronic Obstructive Pulmonary Disease 29373969 miR-34a is involved in CSE-induced apoptosis of human pulmonary microvascular endothelial cells by targeting Notch-1 receptor protein -target gene hsa-mir-328 Colon Neoplasms 29374351 miR-328 mediates a metabolic shift in colon cancer cells by targeting SLC2A1/GLUT1. -target gene hsa-mir-10b "Carcinoma, Hepatocellular" 29375271 MicroRNA-10b regulates epithelial-mesenchymal transition by modulating KLF4/KLF11/Smads in hepatocellular carcinoma -target gene hsa-mir-20a "Carcinoma, Lung, Non-Small-Cell" 29375712 MicroRNA-20a promotes proliferation and invasion by directly targeting early growth response 2 in non-small cell lung carcinoma -target gene hsa-mir-132 Inflammation 29377244 MicroRNA-132 attenuates LPS-induced inflammatory injury by targeting TRAF6 in neuronal cell line HT-22 -target gene hsa-mir-21 Atrial Fibrillation 29380561 These changes can be explained by alterations in the MMP and miR-21/ERK signaling pathways -target gene hsa-mir-130a "Carcinoma, Breast" 29384218 microRNA-130a suppresses breast cancer cell migration and invasion by targeting FOSL1 and upregulating ZO-1. -target gene hsa-mir-522 Colorectal Carcinoma 29386092 miR-522-3p promotes tumorigenesis in human colorectal cancer via targeting bloom syndrome protein. -target gene hsa-mir-383 Lymphoma 29387204 western blot analysis identified zinc finger E-box binding homeobox 2 (ZEB2) as a direct target gene of miR-383 -target gene hsa-mir-144 Osteosarcoma 29387244 miR-144 suppresses proliferation and induces apoptosis of osteosarcoma cells via direct regulation of mTOR expression. -target gene hsa-mir-138 "Carcinoma, Hepatocellular" 29387246 " miR-138 targeted SP1 to repress the growth, migration and invasion of HCC cells, and may therefore represent a therapeutic target in human HCC" -target gene hsa-mir-206 Legg-Calve-Perthes Disease 29387248 Downregulated SOX9 mediated by miR-206 promoted cell apoptosis in Legg-Calv¨¦-Perthes disease. -target gene hsa-mir-210 Kidney Injury 29387863 miR-210 protects renal cell against hypoxia-induced apoptosis by targeting HIF-1 alpha -target gene hsa-mir-646 Colorectal Carcinoma 29391877 Low-level miR-646 in colorectal cancer inhibits cell proliferation and migration by targeting NOB1 expression -target gene hsa-mir-27b Gastric Neoplasms 29393383 "miR-27b may act as a potential biomarker for differentiating patients with GC from healthy controls, and serve as a tumor suppressor in GC by targeting VEGFC" -target gene hsa-mir-29b Neuroblastoma 29399057 MicroRNA-29b alleviates oxygen and glucose deprivation/reperfusion-induced injury via inhibition of the p53-dependent apoptosis pathway in N2a neuroblastoma cells -target gene hsa-mir-9 "Carcinoma, Hepatocellular" 29399149 MicroRNA-9 enhances sensitivity to cetuximab in epithelial phenotypehepatocellular carcinoma cells through regulation of the eukaryotic translation initiation factor 5A-2 -target gene hsa-mir-15a Myeloma 29399181 Downregulation of miRNA-15a and miRNA-16 promote tumor proliferation in multiple myeloma by increasing CABIN1 expression -target gene hsa-mir-16 Myeloma 29399181 Downregulation of miRNA-15a and miRNA-16 promote tumor proliferation in multiple myeloma by increasing CABIN2 expression -target gene hsa-mir-16 Pituitary Neoplasms 29399695 MicroRNA?16/VEGFR2/p38/NF?¦ÊB signaling pathway regulates cell growth of human pituitary neoplasms. -target gene hsa-mir-204 Colorectal Carcinoma 29402343 microRNA-204 inhibits the growth and motility of colorectal cancer cells by downregulation of CXCL8 -target gene hsa-mir-127 "Leukemia, Myeloid, Acute" 29402726 "mRNA and miRNA integrative analyses showed aberrant expression of several hub oncogenes appear to be regulated by some miRNAs like miR-127-5p, miR-494, miR-21 and miR-616 in high TET1 expressers" -target gene hsa-mir-21 "Leukemia, Myeloid, Acute" 29402726 "mRNA and miRNA integrative analyses showed aberrant expression of several hub oncogenes appear to be regulated by some miRNAs like miR-127-5p, miR-494, miR-21 and miR-616 in high TET1 expressers" -target gene hsa-mir-494 "Leukemia, Myeloid, Acute" 29402726 "mRNA and miRNA integrative analyses showed aberrant expression of several hub oncogenes appear to be regulated by some miRNAs like miR-127-5p, miR-494, miR-21 and miR-616 in high TET1 expressers" -target gene hsa-mir-616 "Leukemia, Myeloid, Acute" 29402726 "mRNA and miRNA integrative analyses showed aberrant expression of several hub oncogenes appear to be regulated by some miRNAs like miR-127-5p, miR-494, miR-21 and miR-616 in high TET1 expressers" -target gene hsa-mir-429 "Carcinoma, Hepatocellular" 29403024 The newly identified miR-429-CRKL axis represents a novel potential therapeutic target for HCC treatment -target gene hsa-mir-31 Arteriosclerosis Obliterans 29403548 MicroRNA-31 promotes arterial smooth muscle cell proliferation and migration by targeting mitofusin-2 in arteriosclerosis obliterans of the lower extremitie -target gene hsa-mir-101 "Carcinoma, Endometrial" 29404887 MicroRNA-101 inhibits angiogenesis via COX-2 in endometrial carcinoma. -target gene hsa-mir-29a Diabetic Retinopathy 29409329 Downregulation of MicroRNA 29a/b exacerbated diabetic retinopathy by impairing the function of M¨¹ller cells via Forkhead box protein O4. -target gene hsa-mir-29b Diabetic Retinopathy 29409329 Downregulation of MicroRNA 29a/b exacerbated diabetic retinopathy by impairing the function of M¨¹ller cells via Forkhead box protein O4. -target gene hsa-mir-195 "Carcinoma, Lung, Non-Small-Cell" 29416000 miR-195 targets cyclin D3 and survivin to modulate the tumorigenesis of non-small cell lung cancer -target gene hsa-mir-143 "Carcinoma, Gallbladder" 29416013 miR-143-3p targeting of ITGA6 suppresses tumour growth and angiogenesis by downregulating PLGF expression via the PI3K/AKT pathway in gallbladder carcinoma. -target gene hsa-mir-493 Prostate Neoplasms 29423080 Downregulation of N6-methyladenosine binding YTHDF2 protein mediated by miR-493-3p suppresses prostate cancer by elevating N6-methyladenosine levels. -target gene hsa-mir-199a "Carcinoma, Thyroid, Papillary" 29427661 miR-199a-5p inhibits the progression of papillary thyroid carcinoma by targeting SNAI1. -target gene hsa-mir-145 "Squamous Cell Carcinoma, Esophageal" 29430188 The ROR/miR-145/FSCN1 pathway was shown to take part in the metastasis of ESCC. ROR is likely an oncogene biomarker for ESCC early diagnosis and prognosis -target gene hsa-mir-152 Ovarian Neoplasms 29434752 MicroRNA-152 inhibits ovarian cancer cell proliferation and migration and may infer improved outcomes in ovarian cancer through targeting FOXP1. -target gene hsa-mir-221 Colorectal Carcinoma 29434757 miR-221 inhibits autophagy and targets TP53INP1 in colorectal cancer cells -target gene hsa-mir-150 Melanoma 29434838 MicroRNA-150 inhibitors enhance cell apoptosis of melanoma by targeting PDCD4 -target gene hsa-mir-125b Breast Neoplasms 29434858 miR-125b regulates the drug-resistance of breast cancer cells to doxorubicin by targeting HAX-1 -target gene hsa-mir-34c Laryngeal Neoplasms 29435079 "miR-34c may be involved in the pathogenesis of laryngeal cancer, and BCL2 may be negatively regulated by miR-34c in M4e cell" -target gene hsa-mir-340 Thyroid Neoplasms 29441462 Up-regulation of miR-340-5p promotes progression of thyroid cancer by inhibiting BMP4. -target gene hsa-mir-150 Prostate Neoplasms 29441850 MiR-150 promotes the cell invasion of prostate cancer cells by directly regulating the expression of p53 -target gene hsa-mir-200a Endometrial Neoplasms 29442045 MiR-200a promotes epithelial-mesenchymal transition of endometrial cancer cells by negatively regulating FOXA2 expression -target gene hsa-mir-598 Glioblastoma 29444745 MicroRNA-598 Inhibits Cell Proliferation and Invasion of Glioblastoma by Directly Targeting Metastasis Associated in Colon Cancer-1 (MACC1). -target gene hsa-mir-365 Stroke 29451327 MicroRNA-365 modulates astrocyte conversion into neuron in adult rat brain after stroke by targeting Pax6. -target gene hsa-mir-19b "Carcinoma, Lung, Non-Small-Cell" 29455644 miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancer -target gene hsa-mir-372 Breast Neoplasms 29456685 miR-372 functions as an oncogenic miRNA in breast cancer by targeting LATS2 -target gene hsa-mir-144 Gastric Neoplasms 29456712 MicroRNA-144 functions as a tumor suppressor in gastric cancer by targeting cyclooxygenase-2 -target gene hsa-mir-4295 Prostate Neoplasms 29457293 Ginsenoside Rh2 inhibits prostate cancer cell growth through suppression of microRNA-4295 that activates CDKN1A. -target gene hsa-mir-24 Heart Failure 29457789 miR-24 potently suppresses SCN5A expression and that rs1805126 modulates this regulation -target gene hsa-mir-17 "Lymphoma, Burkitt" 29458013 "In contrast to normal B cells, miRNA target genes in BL were enriched for targets of the oncogenic miR-17 to 92 cluster, and were involved mainly in cell cycle and cell death" -target gene hsa-mir-18 "Lymphoma, Burkitt" 29458013 "In contrast to normal B cells, miRNA target genes in BL were enriched for targets of the oncogenic miR-17 to 93 cluster, and were involved mainly in cell cycle and cell death" -target gene hsa-mir-19a "Lymphoma, Burkitt" 29458013 "In contrast to normal B cells, miRNA target genes in BL were enriched for targets of the oncogenic miR-17 to 94 cluster, and were involved mainly in cell cycle and cell death" -target gene hsa-mir-19b-1 "Lymphoma, Burkitt" 29458013 "In contrast to normal B cells, miRNA target genes in BL were enriched for targets of the oncogenic miR-17 to 96 cluster, and were involved mainly in cell cycle and cell death" -target gene hsa-mir-20a "Lymphoma, Burkitt" 29458013 "In contrast to normal B cells, miRNA target genes in BL were enriched for targets of the oncogenic miR-17 to 95 cluster, and were involved mainly in cell cycle and cell death" -target gene hsa-mir-92-1 "Lymphoma, Burkitt" 29458013 "In contrast to normal B cells, miRNA target genes in BL were enriched for targets of the oncogenic miR-17 to 97 cluster, and were involved mainly in cell cycle and cell death" -target gene hsa-mir-204 Colon Neoplasms 29460671 Targeted delivery of miRNA-204-5p by PEGylated polymer nanoparticles for colon cancer therapy -target gene hsa-mir-210 Ischemia-Reperfusion Injury 29461605 "miR-210, as an upstream factor, plays a protective role in cardiomyocytes through directly inhibiting the protein expression of its target gene E2F3" -target gene hsa-mir-27a Diabetes Mellitus 29462799 miR-27a may contribute to detrusor fibrosis in STZ-induced diabetic rats by targeting PRKAA2 via the TGF-¦Â1/Smad3 signaling pathway -target gene hsa-mir-206 Osteosarcoma 29462818 "Effects of MicroRNA-206 on Osteosarcoma Cell Proliferation, Apoptosis, Migration and Invasion by Targeting ANXA2 Through the AKT Signaling Pathway" -target gene hsa-mir-31 Colorectal Carcinoma 29463215 miR-31 down-regulated c-MET in DLD-1 colon cancer cells -target gene hsa-mir-150 Atherosclerosis 29463607 the decreases in phosphorylated p65 expression and inflammatory cytokine secretion induced by miR-150 ablation were reversed by PDLIM1 knockdown -target gene hsa-mir-21 Pancreatic Neoplasms 29464088 "the expression of two miRComb miR-21 predicted targets, PDCD4 and BTG2, was significantly upregulated in these cells in comparison to control PANC-1" -target gene hsa-mir-7 Gastric Neoplasms 29467883 "YCS inhibits proliferation and induces apoptosis of GC cells mediated by miR-7 targeting EGFR, which may be one of the mechanisms whereby YZSJD exerts its effects on GC" -target gene hsa-mir-96 Bladder Neoplasms 29467898 HERG1 was an important target of miR-96 -target gene hsa-mir-17 "Diabetes Mellitus, Type 2" 29477089 miR-17 improved inflammation-induced insulin resistance by suppressing ASK1 expression in macrophages -target gene hsa-mir-216b Diabetic Vasculopathy 29477872 MicroRNA-216b actively modulates diabetic angiopathy through inverse regulation on FZD5. -target gene hsa-mir-210 Cerebral Ischemia 29478968 miR-210 promoted neovascularization and NPC migration via the SOCS1-STAT3-VEGF-C pathway -target gene hsa-mir-330 Ovarian Neoplasms 29485916 S100A7 Regulates Ovarian Cancer Cell Metastasis and Chemoresistance Through MAPK Signaling and Is Targeted by miR-330-5p. -target gene hsa-mir-140 Osteoarthritis 29488053 "miR-140-5p/miR-149 Affects Chondrocyte Proliferation, Apoptosis, and Autophagy by Targeting FUT1 in Osteoarthritis." -target gene hsa-mir-149 Osteoarthritis 29488053 "miR-140-5p/miR-149 Affects Chondrocyte Proliferation, Apoptosis, and Autophagy by Targeting FUT1 in Osteoarthritis." -target gene hsa-mir-150 Evans Syndrome 29488168 miR-150 regulates B lymphocyte in autoimmune hemolytic anemia/Evans syndrome by c-Myb. -target gene hsa-mir-378 Osteosarcoma 29490146 MiR-378 promotes the cell proliferation of osteosarcoma through down-regulating the expression of Kruppel-like factor 9. -target gene hsa-mir-342 Melanoma 29495972 MicroRNA-342 prohibits proliferation and invasion of melanoma cells by directly targeting Zinc-finger E-box binding homeobox 1 -target gene hsa-mir-140 Colorectal Carcinoma 29499953 miR-140 might be a key suppressor of CRC progression and metastasis through inhibiting EMT process by targeting Smad3 -target gene hsa-mir-23b Sepsis 29506272 "Inhibition of MicroRNA-23b Attenuates Immunosuppression During Late Sepsis Through NIK, TRAF1, and XIAP." -target gene hsa-mir-10b "Carcinoma, Hepatocellular" 29506532 "CADM2, as a new target of miR-10b, promotes tumor metastasis through FAK/AKT pathway in hepatocellular carcinoma" -target gene hsa-mir-223 Atopic Dermatitis 29506638 miR-223 participates in AD through upregulating HNMT indirectly to degrade the excessive histamine -target gene hsa-mir-3147 Vulvar Squamous Cell Carcinoma 29512734 miR?3147 serves as an oncomiR in vulvar squamous cell cancer via Smad4 suppression. -target gene hsa-mir-29c "Carcinoma, Lung, Non-Small-Cell" 29512752 MicroRNA-29c inhibits proliferation and promotes apoptosis in non-small cell lung cancer cells by targeting VEGFA -target gene hsa-mir-139 "Carcinoma, Adrenocortical" 29516499 MiR-483-5p and miR-139-5p promote aggressiveness by targeting N-myc downstream-regulated gene family members in adrenocortical cancer. -target gene hsa-mir-483 "Carcinoma, Adrenocortical" 29516499 MiR-483-5p and miR-139-5p promote aggressiveness by targeting N-myc downstream-regulated gene family members in adrenocortical cancer. -target gene hsa-mir-181a "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 29517349 miR-181a targets GATA6 to inhibit the progression of human laryngeal squamous cell carcinoma. -target gene hsa-mir-449a Breast Neoplasms 29518546 LINC0092 was co-expressed with SFRP1 and RGMA and regulated by hsa-miR-449a and hsa-miR-452-5p -target gene hsa-mir-452 Breast Neoplasms 29518546 LINC0092 was co-expressed with SFRP1 and RGMA and regulated by hsa-miR-449a and hsa-miR-452-5p -target gene hsa-mir-223 Prostate Neoplasms 29518547 MicroRNA-223-3p regulates cell chemo-sensitivity by targeting FOXO3 in prostatic cancer. -target gene hsa-mir-23a "Carcinoma, Nasopharyngeal" 29520105 Metastasis-associated miR-23a from nasopharyngeal carcinoma-derived exosomes mediates angiogenesis by repressing a novel target gene TSGA10 -target gene hsa-let-7a "Squamous Cell Carcinoma, Tongue" 29523225 "These findings revealed that H19/let-7a/HMGA2/EMT axis plays a critical role in the regulation of TSCC migration and invasion, which may provide a new therapeutic target for TSCC cancers" -target gene hsa-mir-223 Viral Myocarditis 29524390 "the data suggest that miR-223 protects against CVB3-induced inflammation and myocardial damage, which may partly attribute to the regulation of macrophage polarization via targeting Pknox1" -target gene hsa-mir-128 Glioma 29524580 MicroRNA-128 inhibits proliferation and invasion of glioma cells by targeting COX-2. -target gene hsa-mir-124 Cerebrovascular Disease 29530526 Levels of tight junction protein CLDND1 are regulated by microRNA-124 in the cerebellum of stroke-prone spontaneously hypertensive rats -target gene hsa-mir-320a Interstitial Cystitis 29531336 "three transcription factors, E2F-1, E2F-2 and TUB, are regulated by miR-320 family miRNAs" -target gene hsa-mir-320b Interstitial Cystitis 29531336 "three transcription factors, E2F-1, E2F-2 and TUB, are regulated by miR-321 family miRNAs" -target gene hsa-mir-320c Interstitial Cystitis 29531336 "three transcription factors, E2F-1, E2F-2 and TUB, are regulated by miR-322 family miRNAs" -target gene hsa-mir-320d Interstitial Cystitis 29531336 "three transcription factors, E2F-1, E2F-2 and TUB, are regulated by miR-323 family miRNAs" -target gene hsa-mir-30a "Carcinoma, Gallbladder" 29540696 "MicroRNA-30a-5p inhibits gallbladder cancer cell proliferation, migration and metastasis by targeting E2F7." -target gene hsa-mir-124 Angiomyolipoma 29540858 "miR-9-5p, miR-124-3p, and miR-132-3p regulate BCL2L11 in tuberous sclerosis complex angiomyolipoma." -target gene hsa-mir-132 Angiomyolipoma 29540858 "miR-9-5p, miR-124-3p, and miR-132-3p regulate BCL2L11 in tuberous sclerosis complex angiomyolipoma." -target gene hsa-mir-9 Angiomyolipoma 29540858 "miR-9-5p, miR-124-3p, and miR-132-3p regulate BCL2L11 in tuberous sclerosis complex angiomyolipoma." -target gene hsa-mir-145 "Carcinoma, Lung, Non-Small-Cell" 29541201 "miR-145 suppresses the proliferation, invasion and migration of NSCLC cells by regulating the BAX/BCL-2 ratio and the caspase-3 cascade" -target gene hsa-mir-155 Diabetic Peripheral Neuropathy 29545091 MiR-155 targets PTCH1 to mediate endothelial progenitor cell dysfunction caused by high glucose. -target gene hsa-mir-205 Rheumatic Heart Diseases 29548280 Hsa miR-205-3p and hsa-miR-3909 were predicted to target the 3'UTR of IL-1¦Â and IL1R1 respectively -target gene hsa-mir-3909 Rheumatic Heart Diseases 29548280 Hsa miR-205-3p and hsa-miR-3909 were predicted to target the 3'UTR of IL-1¦Â and IL1R1 respectively -target gene hsa-mir-320 Cerebral Ischemia 29549732 MicRNA-320 facilitates the brain parenchyma injury via regulating IGF-1 during cerebral I/R injury in mice. -target gene hsa-mir-98 Atherosclerosis 29549823 MicroRNA-98 regulates foam cell formation and lipid accumulation through repression of LOX-1. -target gene hsa-mir-424 "Carcinoma, Breast" 29550638 "miR-424-5p regulates cell proliferation, migration and invasion by targeting doublecortin-like kinase 1 in basal-like breast cancer." -target gene hsa-mir-125b Osteoarthritis 29550827 miR-125b could play an important role in inflammatory injury of chondrogenic cells and miR-125b affected inflammatory injury of ATDC5 cells via regulating expression of MIP-1¦Á and regulating NF-¦ÊB and JNK signaling pathways -target gene hsa-mir-613 "Carcinoma, Hepatocellular" 29551505 MiR-613 functions as tumor suppressor in hepatocellular carcinoma by targeting YWHAZ. -target gene hsa-mir-124 Osteosarcoma 29552134 MicroRNA-124 acts as a tumor-suppressive miRNA by inhibiting the expression of Snail2 in osteosarcoma -target gene hsa-mir-183 "Carcinoma, Renal Cell" 29552228 MicroRNA-183 promotes the proliferation and metastasis of renal cell carcinoma through targeting Dickkopf-related protein 3 -target gene hsa-mir-34a Cardiovascular Diseases [unspecific] 29554593 MiR-34a-5p mediates sevoflurane preconditioning induced inhibition of hypoxia/reoxygenation injury through STX1A in cardiomyocytes. -target gene hsa-mir-155 Colorectal Carcinoma 29556299 MicroRNA-155 acts as a tumor suppressor in colorectal cancer by targeting CTHRC1 in vitro -target gene hsa-mir-200c "Carcinoma, Lung, Non-Small-Cell" 29557087 Anti-invasive effect of Cyclamen pseudibericum extract on A549 non-small cell lung carcinoma cells via inhibition of ZEB1 mediated by miR-200c -target gene hsa-mir-145 Aneurysm 29558369 "miR-145 - pivotal in regulating VSMC plasticity, which is reduced in vascular diseases - was found to control Uhrf1 mRNA translation" -target gene hsa-mir-625 Thyroid Neoplasms 29558717 "MicroRNA-625-3p promotes the proliferation, migration and invasion of thyroid cancer cells by up-regulating astrocyte elevated gene 1." -target gene hsa-mir-532 Ovarian Neoplasms 29558748 Ginsenoside 20(S)-Rg3 Inhibits the Warburg Effect Via Modulating DNMT3A/ MiR-532-3p/HK2 Pathway in Ovarian Cancer Cells. -target gene hsa-mir-199 "Carcinoma, Hepatocellular" 29559347 "MicroRNA-199 suppresses cell proliferation, migration and invasion by downregulating RGS17 in hepatocellular carcinoma." -target gene hsa-mir-24 Hyperglycemia 29559348 MicroRNA-24 regulates vascular remodeling via inhibiting PDGF-BB pathway in diabetic rat model. -target gene hsa-mir-143 Crohn Disease 29562274 MicroRNA-143 Targets ATG2B to Inhibit Autophagy and Increase Inflammatory Responses in Crohn's Disease -target gene hsa-let-7a Hypoxic-Ischemic Encephalopathy 29562785 "The expression levels of the microRNAs (miRs) let-7a and let-7e, known regulators of Casp3, were inversely correlated to Casp3" -target gene hsa-let-7e Hypoxic-Ischemic Encephalopathy 29562785 "The expression levels of the microRNAs (miRs) let-7a and let-7e, known regulators of Casp3, were inversely correlated to Casp3" -target gene hsa-mir-302a Osteosarcoma 29563995 MicroRNA-302a inhibits osteosarcoma cell migration and invasion by directly targeting IGF-1R. -target gene hsa-mir-21 Colon Neoplasms 29564000 Berberine regulates the microRNA-21-ITG¦¢4-PDCD4 axis and inhibits colon cancer viability -target gene hsa-mir-155 "Carcinoma, Hepatocellular" 29565484 "MiR-155 targeted and inhibited FoxO3a expression to suppress the BIM, depress caspase-3 and caspase-9 activities, therefore inhibiting the HCC cell apoptosis and facilitating proliferation" -target gene hsa-mir-145 Breast Neoplasms 29565493 "MiR-145 affects breast cancer BS524 cell proliferation, infiltration, and migration via positively regulating OCT4 gene expression" -target gene hsa-mir-422a Colorectal Carcinoma 29566993 MiR-422a targets MAPKK6 and regulates cell growth and apoptosis in colorectal cancer cells. -target gene hsa-mir-149 Neoplasms [unspecific] 29568059 Cell-autonomous and cell non-autonomous downregulation of tumor suppressor DAB2IP by microRNA-149-3p promotes aggressiveness of cancer cells. -target gene hsa-mir-128 Neoplasms [unspecific] 29568354 miR-128 inhibits telomerase activity by targeting TERT mRNA -target gene hsa-mir-19a Gastric Neoplasms 29568890 miR-19a/b and MeCP2 repress reciprocally to regulate multidrug resistance in gastric cancer cells. -target gene hsa-mir-19b Gastric Neoplasms 29568890 miR-19a/b and MeCP2 repress reciprocally to regulate multidrug resistance in gastric cancer cells. -target gene hsa-mir-29b Renal Fibrosis 29568897 miR-29b regulates Ang II-induced EMT of rat renal tubular epithelial cells via targeting PI3K/AKT signaling pathway. -target gene hsa-mir-124 Acute Kidney Failure 29568906 miR-124/MCP-1 signaling pathway modulates the protective effect of itraconazole on acute kidney injury in a mouse model of disseminated candidiasis. -target gene hsa-mir-375 "Fatty Liver, Non-Alcoholic" 29569260 Down-regulation of microRNA-375 regulates adipokines and inhibits inflammatory cytokines by targeting AdipoR2 in non-alcoholic fatty liver disease -target gene hsa-mir-491 Gastric Neoplasms 29569792 Downregulation of miR-491-5p promotes gastric cancer metastasis by regulating SNAIL and FGFR4. -target gene hsa-mir-17 Neoplasms [unspecific] 29574928 "The role of miR-17/92 family in development and progression of various cancers has been established. The members of this miRNA family have been shown to be over expressed and target various genes within proliferation, metastasis and angiogenesis pathways." -target gene hsa-mir-18 Neoplasms [unspecific] 29574928 "The role of miR-17/92 family in development and progression of various cancers has been established. The members of this miRNA family have been shown to be over expressed and target various genes within proliferation, metastasis and angiogenesis pathways." -target gene hsa-mir-19a Neoplasms [unspecific] 29574928 "The role of miR-17/92 family in development and progression of various cancers has been established. The members of this miRNA family have been shown to be over expressed and target various genes within proliferation, metastasis and angiogenesis pathways." -target gene hsa-mir-19b-1 Neoplasms [unspecific] 29574928 "The role of miR-17/92 family in development and progression of various cancers has been established. The members of this miRNA family have been shown to be over expressed and target various genes within proliferation, metastasis and angiogenesis pathways." -target gene hsa-mir-20a Neoplasms [unspecific] 29574928 "The role of miR-17/92 family in development and progression of various cancers has been established. The members of this miRNA family have been shown to be over expressed and target various genes within proliferation, metastasis and angiogenesis pathways." -target gene hsa-mir-92-1 Neoplasms [unspecific] 29574928 "The role of miR-17/92 family in development and progression of various cancers has been established. The members of this miRNA family have been shown to be over expressed and target various genes within proliferation, metastasis and angiogenesis pathways." -target gene hsa-mir-374b "Carcinoma, Cervical" 29575013 MicroRNA-374b inhibits cervical cancer cell proliferation and induces apoptosis through the p38/ERK signaling pathway by binding to JAM-2. -target gene hsa-mir-34a Gastric Neoplasms 29581731 MicroRNA-34a regulates proliferation and apoptosis of gastric cancer cells by targeting silent information regulator 1 -target gene hsa-mir-155 Sezary Disease 29582620 HERV-K and HERV-W expression is regulated by mir-155 in S¨¦zary syndrome -target gene hsa-mir-9 Metabolic Syndrome 29584810 Identification of miR-9-5p as direct regulator of ABCA1 and HDL-driven reverse cholesterol transport in circulating CD14+ cells of patients with metabolic syndrome. -target gene hsa-mir-30a Liver Fibrosis 29587268 "miR-30a inhibits EMT process, at least in part, via reduction of Snai1, leading to the suppression of HSC activation in liver fibrosis" -target gene hsa-mir-146a Mesial Temporal Lobe Epilepsy 29590637 modulation of the miR-146a-CFH-IL-1¦Â loop circuit could be a novel therapeutic target for TLE -target gene hsa-mir-122 Chronic Hepatitis C 29593672 the liver-specific microRNA-122 (miR-122) binds to two target sites at the 5' end of the viral RNA genome as well as to at least three additional target sites in the coding region and the 3' UTR -target gene hsa-mir-326 Sickle Cell Disease 29601850 miR-326 regulates HbF synthesis by targeting EKLF in human erythroid cells. -target gene hsa-mir-9 "Carcinoma, Cervical" 29602130 The mechanisms involved in miR-9 regulated apoptosis in cervical cancer by targeting FOXO3. -target gene hsa-mir-451a "Fatty Liver, Non-Alcoholic" 29604329 MiR-451a attenuates free fatty acids-mediated hepatocyte steatosis by targeting the thyroid hormone responsive spot 14 gene. -target gene hsa-mir-181c Diabetes Mellitus 29605252 miR-181c-3p and -5p promotes high-glucose-induced dysfunction in human umbilical vein endothelial cells by regulating leukemia inhibitory factor. -target gene hsa-mir-370 "Squamous Cell Carcinoma, Esophageal" 29605603 Downregulation of microRNA-370 in esophageal squamous-cell carcinoma is associated with cancer progression and promotes cancer cell proliferation via upregulating PIN1. -target gene hsa-mir-6086 Cardiovascular Diseases [unspecific] 29605606 Inhibition of hsa-miR-6086 protects human umbilical vein endothelial cells against TNF¦Á-induced proliferation inhibition and apoptosis via CDH5. -target gene hsa-mir-204 Neuroblastoma 29610116 Network Modeling of microRNA-mRNA Interactions in Neuroblastoma Tumorigenesis Identifies miR-204 as a Direct Inhibitor of MYCN. -target gene hsa-mir-125b "Meningitis, Pneumococcal" 29611100 "hsa-miR-25-3p and hsa-miR-125b-5p target the transcription factor TEF-1, for which there are binding sites in Il-1¦Â, Ccl 2 , and Ccl 3 genes" -target gene hsa-mir-25 "Meningitis, Pneumococcal" 29611100 "hsa-miR-25-3p and hsa-miR-125b-5p target the transcription factor TEF-1, for which there are binding sites in Il-1¦Â, Ccl 2 , and Ccl 3 genes" -target gene hsa-mir-7 Breast Neoplasms 29614984 Our data uncovered a crucial role of TINCR-miR-7-KLF4 axis in human breast cancer -target gene hsa-mir-140 "Carcinoma, Lung, Non-Small-Cell" 29617683 MiR-140 Expression Regulates Cell Proliferation and Targets PD-L1 in NSCLC -target gene hsa-mir-145 Neuroblastoma 29619741 Expression of miR-145 and Its Target Proteins Are Regulated by miR-29b in Differentiated Neurons -target gene hsa-mir-29b Neuroblastoma 29619741 Expression of miR-145 and Its Target Proteins Are Regulated by miR-29b in Differentiated Neurons -target gene hsa-mir-200a "Carcinoma, Ovarian" 29620165 FOXD1 is targeted by miR-30a-5p and miR-200a-5p and suppresses the proliferation of human ovarian carcinoma cells by promoting p21 expression in a p53-independent manner. -target gene hsa-mir-30a "Carcinoma, Ovarian" 29620165 FOXD1 is targeted by miR-30a-5p and miR-200a-5p and suppresses the proliferation of human ovarian carcinoma cells by promoting p21 expression in a p53-independent manner. -target gene hsa-mir-31a Hypertension 29620173 Deregulation of microRNA?31a?5p is involved in the development of primary hypertension by suppressing apoptosis of pulmonary artery smooth muscle cells via targeting TP53. -target gene hsa-mir-612 "Carcinoma, Bladder" 29620192 Tumor-suppressing effects of microRNA-612 in bladder cancer cells by targeting malic enzyme 1 expression. -target gene hsa-mir-130b Lupus Nephritis 29620214 Dysregulation of PTEN caused by the underexpression of microRNA?130b is associated with the severity of lupus nephritis. -target gene hsa-mir-149 "Carcinoma, Colon" 29620230 Formononetin inhibits colon carcinoma cell growth and invasion by microRNA?149?mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways. -target gene hsa-mir-328 "Carcinoma, Breast" 29620238 miR-328-5p inhibits MDA-MB-231 breast cancer cell proliferation by targeting RAGE. -target gene hsa-mir-142 "Carcinoma, Breast" 29620260 MicroRNA?142?5p modulates breast cancer cell proliferation and apoptosis by targeting phosphatase and tensin homolog. -target gene hsa-mir-152 Renal Fibrosis 29620271 miR?152 regulates TGF?¦Â1?induced epithelial?mesenchymal transition by targeting HPIP in tubular epithelial cells. -target gene hsa-mir-429 Peripheral Nerve Injury 29624520 Inhibition of microRNA-429 attenuates oxygen-glucose deprivation/reoxygenation-induced neuronal injury by promoting expression of GATA-binding protein 4. -target gene hsa-mir-675 Osteosarcoma 29626470 Exosomal miR-675 from metastatic osteosarcoma promotes cell migration and invasion by targeting CALN1. -target gene hsa-mir-767 "Carcinoma, Hepatocellular" 29627570 Circular RNA hsa_circ_0000673 promotes hepatocellular carcinoma malignance by decreasing miR-767-3p targeting SET. -target gene hsa-mir-145 "Carcinoma, Hepatocellular" 29630879 Atorvastatin induces MicroRNA-145 expression in HEPG2 cells via regulation of the PI3K/AKT signalling pathway -target gene hsa-mir-4319 Prostate Neoplasms 29633185 Re-expression of microRNA-4319 inhibits growth of prostate cancer via Her-2 suppression. -target gene hsa-mir-103a "Carcinoma, Hepatocellular" 29637568 Hepatoma cell-secreted exosomal microRNA-103 increases vascular permeability and promotes metastasis by targeting junction proteins. -target gene hsa-mir-26a "Carcinoma, Hepatocellular" 29653269 MicroRNA-26a is a key regulon that inhibits progression and metastasis of c-Myc/EZH2 double high advanced hepatocellular carcinoma. -target gene hsa-mir-20a Atherosclerosis 29653364 MicroRNA-20a protects human aortic endothelial cells from Ox-LDL-induced inflammation through targeting TLR4 and TXNIP signaling. -target gene hsa-mir-130b Lung Neoplasms 29653464 MicroRNA-130b targets PTEN to induce resistance to cisplatin in lung cancer cells by activating Wnt/¦Â-catenin pathway. -target gene hsa-mir-449a Breast Neoplasms 29653747 MiR-449a suppresses cell migration and invasion by targeting PLAGL2 in breast cancer -target gene hsa-mir-96 Osteosarcoma 29656060 microRNA-96 acts as a tumor suppressor gene in human osteosarcoma via target regulation of EZRIN -target gene hsa-mir-146a Acute Lung Injury 29658581 MicroRNA?146a/Toll?like receptor 4 signaling protects against severe burn?induced remote acute lung injury in rats via anti?inflammation. -target gene hsa-mir-96 "Carcinoma, Hepatocellular" 29658604 Oncogenic miR-96-5p inhibits apoptosis by targeting the caspase-9 gene in hepatocellular carcinoma. -target gene hsa-mir-155 "Leukemia, Lymphocytic, Chronic, B-Cell" 29658610 Overexpression of IL-9 induced by STAT3 phosphorylation is mediated by miR-155 and miR-21 in chronic lymphocytic leukemia -target gene hsa-mir-21 "Leukemia, Lymphocytic, Chronic, B-Cell" 29658610 Overexpression of IL-9 induced by STAT3 phosphorylation is mediated by miR-155 and miR-21 in chronic lymphocytic leukemia -target gene hsa-mir-222 Hypertrophic Scar 29658663 microRNA-222 regulates proliferation and apoptosis of fibroblasts in hypertrophic scar via matrix metalloproteinase 1 -target gene hsa-mir-223 "Adenocarcinoma, Colon" 29660302 miR-223-RhoB signaling pathway regulates the proliferation and apoptosis of colon adenocarcinoma -target gene hsa-mir-92a Diabetes Mellitus 29660330 MiRNA-92a protects pancreatic B-cell function by targeting KLF2 in diabetes mellitus -target gene hsa-mir-155 Esophageal Neoplasms 29660336 MicroRNA-155 inversely correlates with esophageal cancer progression through regulating tumor-associated macrophage FGF2 expression. -target gene hsa-mir-758 Atherosclerosis 29660520 miR-758 mediates oxLDL-dependent vascular endothelial cell damage by suppressing the succinate receptor SUCNR1. -target gene hsa-mir-32 Breast Neoplasms 29661250 "oncogenic miR-32 and miR-92b were identified to suppress IDH1 expression, leading to the inhibition of cell migration and invasion" -target gene hsa-mir-92b Breast Neoplasms 29661250 "oncogenic miR-32 and miR-92b were identified to suppress IDH1 expression, leading to the inhibition of cell migration and invasion" -target gene hsa-mir-548k Myasthenia Gravis 29661539 miR-548k regulates CXCL13 expression in myasthenia gravis patients with thymic hyperplasia and in Jurkat cells. -target gene hsa-mir-27b Mycobacterium tuberculosis Infection 29661829 we revealed a novel role of the miR-27b/Bag2 axis in the regulation of inflammatory response and apoptosis and provide a potential molecular host defense mechanism against mycobacteria -target gene hsa-mir-29b Pulmonary Hypertension 29662889 Effect of miR-29b on the Proliferation and Apoptosis of Pulmonary Artery Smooth Muscle Cells by Targeting Mcl-1 and CCND2 -target gene hsa-mir-370 Atherosclerosis 29663491 miR-370 can reduce inflammatory reaction and inhibit the ROS production by targeting TLR4 in THP-1 cells -target gene hsa-mir-135a Atherosclerosis 29663503 MiR-135a represses oxidative stress and vascular inflammatory events via targeting toll-like receptor 4 in atherogenesis. -target gene hsa-mir-21 "Adenocarcinoma, Lung" 29663730 MiR-21 improves invasion and migration of drug-resistant lung adenocarcinoma cancer cell and transformation of EMT through targeting HBP1 -target gene hsa-mir-19a Hypertrophy 29664809 MicroRNA-19a/b-3p protect the heart from hypertension-induced pathological cardiac hypertrophy through PDE5A. -target gene hsa-mir-19b Hypertrophy 29664809 MicroRNA-19a/b-3p protect the heart from hypertension-induced pathological cardiac hypertrophy through PDE5A. -target gene hsa-mir-195 Prostate Neoplasms 29665645 MicroRNA-195 regulates docetaxel resistance by targeting clusterin in prostate cancer -target gene hsa-mir-29b Inflammation 29665646 miR-29b could regulate LPS-induced endothelial cells inflammatory injury through regulation of NF-¦ÊB and JNK signaling pathways -target gene hsa-mir-30a "Carcinoma, Breast, Triple Negative" 29666469 A p53/miR-30a/ZEB2 axis controls triple negative breast cancer aggressiveness -target gene hsa-mir-146a Cor Pulmonale 29667303 miR-146a can negatively feedback regulate PM1 -induced inflammation via NF-¦ÊB signaling pathway in BEAS-2B cells -target gene hsa-mir-193a "Carcinoma, Renal Cell" 29667779 "MiR-193a-3p and miR-224 mediate renal cell carcinoma progression by targeting alpha-2,3-sialyltransferase IV and the phosphatidylinositol 3 kinase/Akt pathway." -target gene hsa-mir-224 "Carcinoma, Renal Cell" 29667779 "MiR-193a-3p and miR-224 mediate renal cell carcinoma progression by targeting alpha-2,3-sialyltransferase IV and the phosphatidylinositol 3 kinase/Akt pathway." -target gene hsa-mir-122 Chronic Hepatitis C 29669014 miR-122 positively regulates HCV replication by a direct interaction with the 5' untranslated region (UTR) of the viral RNA -target gene hsa-mir-182 Myocardial Infarction 29671338 Inhibition of miR-182-5p protects cardiomyocytes from hypoxia-induced apoptosis by targeting CIAPIN1. -target gene hsa-mir-145 "Carcinoma, Breast, Triple Negative" 29673594 LincRNA-RoR/miR-145 promote invasion and metastasis in triple-negative breast cancer via targeting MUC1. -target gene hsa-mir-373 Lung Neoplasms 29673878 Down-regulation of miR-373 increases the radiosensitivity of lung cancer cells by targeting TIMP2. -target gene hsa-mir-21 Ischemia-Reperfusion Injury 29674977 the programmed cell death 4 (PDCD4) expression was identified as a target gene of miR-21 -target gene hsa-mir-21 Myocardial Infarction 29674977 the programmed cell death 4 (PDCD4) expression was identified as a target gene of miR-21 -target gene hsa-mir-375 Allergic Rhinitis 29677549 miR-375 prevents nasal mucosa cells from apoptosis and ameliorates allergic rhinitis via inhibiting JAK2/STAT3 pathway. -target gene hsa-mir-577 Osteoarthritis 29678573 Long non-protein coding RNA DANCR functions as a competing endogenous RNA to regulate osteoarthritis progression via miR-577/SphK2 axis. -target gene hsa-mir-485 "Carcinoma, Breast" 29678577 miR-485-5p suppresses breast cancer progression and chemosensitivity by targeting survivin. -target gene hsa-mir-338 "Carcinoma, Salivary Adenoid Cystic" 29678584 miR-338-5p/3p target LAMC2 to impair motility and invasion of ACC-M and MDA-MB-231?cells -target gene hsa-mir-876 "Carcinoma, Hepatocellular" 29679906 MicroRNA-876-5p inhibits epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma by targeting BCL6 corepressor like 1. -target gene hsa-mir-485 Colorectal Carcinoma 29680296 MicroRNA-485-5p reduces O-GlcNAcylation of Bmi-1 and inhibits colorectal cancer proliferation. -target gene hsa-mir-155 Cardiovascular Diseases [unspecific] 29686722 Analysis of microRNA-155 expression also suggests its intervention in the regulation of eNOS expression. -target gene hsa-mir-21 Gastric Neoplasms 29687845 miRNA-21 may promote the growth of gastric cancer cells by adjusting and controlling PTEN/Akt signal passage mediated PEG2 -target gene hsa-mir-150 Sepsis 29689269 MiR-150 predicts survival in patients with sepsis and inhibits LPS-induced inflammatory factors and apoptosis by targeting NF-¦ÊB1 in human umbilical vein endothelial cells. -target gene hsa-mir-125b Arteriosclerosis Obliterans 29689557 Exogenous miR-125b expression modulated SRF expression and inhibited vascular neointimal formation in balloon-injured rat carotid arteries -target gene hsa-mir-34a Breast Neoplasms 29689563 MicroRNA-34a Inhibition of the TLR Signaling Pathway Via CXCL10 Suppresses Breast Cancer Cell Invasion and Migration -target gene hsa-mir-96 Diabetic Peripheral Neuropathy 29689688 Swimming Exercise Induced Reversed Expression of miR-96 and Its Target Gene NaV1.3 in Diabetic Peripheral Neuropathy in Rats -target gene hsa-mir-222 Liver Neoplasms 29693134 "miRNA?222 promotes liver cancer cell proliferation, migration and invasion and inhibits apoptosis by targeting BBC3." -target gene hsa-mir-145 Bladder Neoplasms 29693148 microRNA?145 modulates migration and invasion of bladder cancer cells by targeting N?cadherin. -target gene hsa-mir-125 Colorectal Carcinoma 29693153 MicroRNA?125 inhibits RKO colorectal cancer cell growth by targeting VEGF. -target gene hsa-mir-221 Myocardial Ischemic-Reperfusion Injury 29693157 MicroRNA?221?3p contributes to cardiomyocyte injury in H2O2?treated H9c2 cells and a rat model of myocardial ischemia?reperfusion by targeting p57. -target gene hsa-mir-146a "Carcinoma, Cervical" 29693168 miR-146a promotes cervical cancer cell viability via targeting IRAK1 and TRAF6. -target gene hsa-mir-384 "Carcinoma, Breast" 29693185 MicroRNA-384 inhibits the progression of breast cancer by targeting ACVR1. -target gene hsa-mir-27a Heart Diseases [unspecific] 29694513 miR-27a protects human mitral valve interstitial cell from TNF-¦Á-induced inflammatory injury via up-regulation of NELL-1. -target gene hsa-mir-1307 "Carcinoma, Breast" 29697201 Mir-1307 regulates cisplatin resistance by targeting Mdm4 in breast cancer expressing wild type P53. -target gene hsa-mir-382 Diabetic Nephropathy 29701296 Repression of microRNA-382 inhibits glomerular mesangial cell proliferation and extracellular matrix accumulation via FoxO1 in mice with diabetic nephropathy. -target gene hsa-mir-223 Colorectal Carcinoma 29701752 MiR-223 promotes the doxorubicin resistance of colorectal cancer cells via regulating epithelial-mesenchymal transition by targeting FBXW7. -target gene hsa-mir-98 "Carcinoma, Hepatocellular" 29702181 MiR-98 suppresses the effects of tumor-associated macrophages on promoting migration and invasion of hepatocellular carcinoma cells by regulating IL-10. -target gene hsa-mir-19 Osteosarcoma 29702193 miR-19a-mediated downregulation of RhoB inhibits the dephosphorylation of AKT1 and induces osteosarcoma cell metastasis. -target gene hsa-mir-124a "Carcinoma, Lung, Non-Small-Cell" 29702194 Tumor suppressive microRNA-124a inhibits stemness and enhances gefitinib sensitivity of non-small cell lung cancer cells by targeting ubiquitin-specific protease 14. -target gene hsa-mir-146a Coronavirus Infections 29702211 miR-146a-5p promotes replication of infectious bronchitis virus by targeting IRAK2 and TNFRSF18. -target gene hsa-mir-34a Atherosclerosis 29704100 Downregulation of miR-34a promotes endothelial cell growth and suppresses apoptosis in atherosclerosis by regulating Bcl-2. -target gene hsa-mir-502 Esophageal Neoplasms 29709473 MiR-502 mediates esophageal cancer cell TE1 proliferation by promoting AKT phosphorylation. -target gene hsa-mir-600 Colorectal Carcinoma 29710537 Hsa_circ_0071589 promotes carcinogenesis via the miR-600/EZH2 axis in colorectal cancer. -target gene hsa-mir-338 Melanoma 29710538 MiR-338-5p promotes the growth and metastasis of malignant melanoma cells via targeting CD82. -target gene hsa-mir-210 Myocardial Infarction 29710553 MicroRNA-210 aggravates hypoxia-induced injury in cardiomyocyte H9c2 cells by targeting CXCR4. -target gene hsa-mir-361 "Carcinoma, Thyroid, Papillary" 29710554 MicroRNA-361-5p inhibits papillary thyroid carcinoma progression by targeting ROCK1. -target gene hsa-mir-20a "Carcinoma, Cervical" 29710555 Up-regulation of miR-20a by HPV16 E6 exerts growth-promoting effects by targeting PDCD6 in cervical carcinoma cells. -target gene hsa-mir-340 Angiosarcoma 29710664 MicroRNA-340 inhibits the growth and invasion of angiosarcoma cells by targeting SIRT7. -target gene hsa-mir-30a Giant Cell Tumor of Bone 29710674 Norcantharidin modulates the miR-30a/Metadherin/AKT signaling axis to suppress proliferation and metastasis of stromal tumor cells in giant cell tumor of bone. -target gene hsa-mir-10a Glioma 29713056 Immunosuppressive effects of hypoxia-induced glioma exosomes through myeloid-derived suppressor cells via the miR-10a/Rora and miR-21/Pten Pathways. -target gene hsa-mir-21 Glioma 29713056 Immunosuppressive effects of hypoxia-induced glioma exosomes through myeloid-derived suppressor cells via the miR-10a/Rora and miR-21/Pten Pathways. -target gene hsa-mir-122 Stroke 29715465 Up-regulation of miR-122 protects against neuronal cell death in ischemic stroke through the heat shock protein 70-dependent NF-¦ÊB pathway by targeting FOXO3. -target gene hsa-mir-29c Prostate Neoplasms 29715514 Up-regulated miR-29c inhibits cell proliferation and glycolysis by inhibiting SLC2A3 expression in prostate cancer. -target gene hsa-mir-146a Human Immunodeficiency Virus Infection 29717615 HIV-1-Induced miR-146a Attenuates Monocyte Migration by Targeting CCL5 in Human Primary Macrophages. -target gene hsa-mir-652 Prostate Neoplasms 29721191 MicroRNA-652 induces NED in LNCaP and EMT in PC3 prostate cancer cells. -target gene hsa-mir-146 Colorectal Carcinoma 29722931 "miR-146b-5p was shown to increase EMT by targeting Smad4, and the miR-146b-5p-Smad4 cascade regulated EMT in CRC" -target gene hsa-mir-146b Colorectal Carcinoma 29722931 "MiR-146b-5p was shown to increase EMT by targeting Smad4, and the miR-146b-5p-Smad4 cascade regulated EMT in CRC" -target gene hsa-mir-876 "Carcinoma, Hepatocellular" 29724530 MiR-876-5p acts as an inhibitor in hepatocellular carcinoma progression by targeting DNMT3A. -target gene hsa-mir-505 Colorectal Carcinoma 29726011 MiR-505 mediates methotrexate resistance in colorectal cancer by targeting RASSF8. -target gene hsa-mir-154 "Squamous Cell Carcinoma, Skin or Unspecific" 29727714 Inhibitory effect of microRNA-154 targeting WHSC1 on cell proliferation of human skin squamous cell carcinoma through mediating the P53 signaling pathway. -target gene hsa-mir-545 Gastric Neoplasms 29733519 MiRNA-545 negatively regulates the oncogenic activity of EMS1 in gastric cancer. -target gene hsa-mir-301b Diabetes Mellitus 29733818 The miR-301b-AMPD3 axis may be a novel therapeutic target for intervening enegy metabolism in diabetic hearts -target gene hsa-mir-182 Acute Kidney Failure 29733821 miR-182 enhances acute kidney injury by promoting apoptosis involving the targeting and regulation of TCF7L2/Wnt/¦Â-catenins pathway. -target gene hsa-mir-339 "Leukemia, Lymphoblastic, Acute" 29735550 miR-339 Promotes Development of Stem Cell Leukemia/Lymphoma Syndrome via Downregulation of the BCL2L11 and BAX Proapoptotic Genes. -target gene hsa-mir-181a Atherosclerosis 29737518 MiR-181a inhibits vascular inflammation induced by ox-LDL via targeting TLR4 in human macrophages. -target gene hsa-mir-411 Spinal Cord Injuries 29738767 miR-411 suppresses acute spinal cord injury via downregulation of Fas ligand in rats. -target gene hsa-mir-130a "Carcinoma, Breast" 29746865 MiR-130a-3p inhibits migration and invasion by regulating RAB5B in human breast cancer stem cell-like cells. -target gene hsa-mir-26a Lung Neoplasms 29746867 MiR-26a-5p potentiates metastasis of human lung cancer cells by regulating ITG¦Â8- JAK2/STAT3 axis. -target gene hsa-mir-302e Allergic Asthma 29748238 MiR-302e attenuates allergic inflammation in vitro model by targeting RelA. -target gene hsa-mir-129 Wound Healing 29748291 MicroRNA-129 and -335 Promote Diabetic Wound Healing by Inhibiting Sp1-Mediated MMP-9 Expression. -target gene hsa-mir-335 Wound Healing 29748291 MicroRNA-129 and -335 Promote Diabetic Wound Healing by Inhibiting Sp1-Mediated MMP-9 Expression. -target gene hsa-mir-215 Hepatitis C Virus Infection 29749134 miR-215 Enhances HCV Replication by Targeting TRIM22 and Inactivating NF-¦ÊB Signaling. -target gene hsa-mir-145 "Carcinoma, Lung, Non-Small-Cell" 29749434 miR?145 inhibits human non?small-cell lung cancer growth by dual-targeting RIOK2 and NOB1. -target gene hsa-mir-125a "Carcinoma, Pancreatic" 29749475 "miR-125a induces apoptosis, metabolism disorder and migrationimpairment in pancreatic cancer cells by targeting Mfn2-related mitochondrial fission." -target gene hsa-mir-23a "Carcinoma, Pancreatic" 29749476 miR?23a suppresses pancreatic cancer cell progression by inhibiting PLK?1 expression. -target gene hsa-mir-486 Osteoarthritis 29749497 miR?486?5p is upregulated in osteoarthritis and inhibits chondrocyte proliferation and migration by suppressing SMAD2. -target gene hsa-mir-125b "Squamous Cell Carcinoma, Esophageal" 29749531 MicroRNA-125b inhibits cell proliferation and induces cell apoptosis in esophageal squamous cell carcinoma by targeting BMF. -target gene hsa-mir-23b "Squamous Cell Carcinoma, Esophageal" 29750239 MiR-23b-3p induces the proliferation and metastasis of esophageal squamous cell carcinomas cells through the inhibition of EBF3. -target gene hsa-mir-150 Colorectal Carcinoma 29750311 MicroRNA-150 inhibits the proliferation and metastasis potential of colorectal cancer cells by targeting iASPP. -target gene hsa-mir-196b "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 29753737 miR-196b is a prognostic factor of human laryngeal squamous cell carcinoma and promotes tumor progression by targeting SOCS2. -target gene hsa-mir-665 Intervertebral Disc Degeneration 29761869 microRNA-665 promotes the proliferation and matrix degradation of nucleus pulposus through targeting GDF5 in intervertebral disc degeneration. -target gene hsa-mir-130 Myocardial Infarction 29761875 miR-130 aggravates acute myocardial infarction-induced myocardial injury by targeting PPAR-¦Ã. -target gene hsa-mir-216a Melanoma 29763606 MiR-216a-5p/Hexokinase 2 axis regulates uveal melanoma growth through modulation of Warburg effect. -target gene hsa-mir-141 Gastric Cardia Adenocarcinoma 29765447 MicroRNA-141 inhibits proliferation of gastric cardia adenocarcinoma by targeting MACC1. -target gene hsa-mir-142 "Carcinoma, Lung, Non-Small-Cell" 29767245 miR-142-5p regulates CD4+ T cells in human non-small cell lung cancer through PD-L1 expression via the PTEN pathway. -target gene hsa-mir-155 Lymphocytic Choriomeningitis 29768211 Long-Term Persistence of Exhausted CD8?T Cells in Chronic Infection Is Regulated by MicroRNA-155. -target gene hsa-mir-1247 Pneumonia 29768218 MicroRNA-1247 inhibits lipopolysaccharides-induced acute pneumonia in A549 cells via targeting CC chemokine ligand 16. -target gene hsa-mir-520h "Leukemia, Lymphoblastic, Acute" 29768346 "Additionally, POLD1 and MCM2 were found to be regulated by miR-520H via E2F1" -target gene hsa-let-7e Dengue Shock Syndrome 29768655 Let-7e inhibits TNF-¦Á expression by targeting the methyl transferase EZH2 in DENV2-infected THP-1 cells. -target gene hsa-mir-340 Osteosarcoma 29769415 "Upregulation of microRNA-340 promotes osteosarcoma cell apoptosis while suppressing proliferation, migration and invasion by inactivating the CTNNB1-mediated Notch signaling pathway." -target gene hsa-mir-92a "Squamous Cell Carcinoma, Oral" 29772443 MiR-92a regulates oral squamous cell carcinoma (OSCC) cell growth by targeting FOXP1 expression. -target gene hsa-mir-1231 Glioma 29774498 MicroRNA-1231 exerts a tumor suppressor role through regulating the EGFR/PI3K/AKT axis in glioma. -target gene hsa-mir-7 White Spot Syndrome Virus Infection 29775740 Eriocheir sinensis microRNA-7 targets crab Myd88 to enhance white spot syndrome virus replication. -target gene hsa-mir-608 "Carcinoma, Hepatocellular" 29777702 microRNA-608 inhibits human hepatocellular carcinoma cell proliferation via targeting the BET family protein BRD4. -target gene hsa-mir-616 Gastric Neoplasms 29777710 MiR-616-3p promotes angiogenesis and EMT in gastric cancer via the PTEN/AKT/mTOR pathway. -target gene hsa-mir-129 Ovarian Neoplasms 29777711 UCA1 confers paclitaxel resistance to ovarian cancer through miR-129/ABCB1 axis. -target gene hsa-mir-663a "Carcinoma, Gallbladder" 29778567 "EMP3, which is regulated by miR-663a, suppresses gallbladder cancer progression via interference with the MAPK/ERK pathway." -target gene hsa-mir-485 Colorectal Carcinoma 29781037 MicroRNA-485 plays tumour-suppressive roles in colorectal cancer by directly targeting GAB2. -target gene hsa-mir-1178 Tuberculosis 29781535 MiR-1178 regulates mycobacterial survival and inflammatory responses in Mycobacterium tuberculosis-infected macrophages partly via TLR4. -target gene hsa-mir-19a Ovarian Neoplasms 29783075 MiR-19a negatively regulated the expression of PTEN and promoted the growth of ovarian cancer cells. -target gene hsa-mir-155 Hypertrophic Scar 29785488 miR-155 inhibits the formation of hypertrophic scar fibroblasts by targeting HIF-1¦Á via PI3K/AKT pathway. -target gene hsa-mir-494 Gastric Neoplasms 29786108 miR?494 inhibits cancer?initiating cell phenotypes and reverses resistance to lapatinib by downregulating FGFR2 in HER2?positive gastric cancer. -target gene hsa-mir-137 "Diabetes Mellitus, Gestational" 29786111 High glucose suppresses the viability and proliferation of HTR?8/SVneo cells through regulation of the miR?137/PRKAA1/IL?6 axis. -target gene hsa-mir-137 Osteoporosis 29786747 MicroRNA-137 dysregulation predisposes to osteoporotic fracture by impeding ALP activity and expression via suppression of leucine-rich repeat-containing G-protein-coupled receptor 4 expression. -target gene hsa-mir-20b Ischemia-Reperfusion Injury 29786750 MicroRNA?20b?5p promotes ventricular remodeling by targeting the TGF?¦Â/Smad signaling pathway in a rat model of ischemia?reperfusion injury. -target gene hsa-mir-24 Obesity 29787826 Obesity-induced overexpression of miRNA-24 regulates cholesterol uptake and lipid metabolism by targeting SR-B1. -target gene hsa-mir-216b Glioma 29787989 Downregulation of microRNA-216b contributes to glioma cell growth and migration by promoting AEG-1-mediated signaling. -target gene hsa-mir-320a MALT Lymphoma 29788729 "the TF MYC was a co-target of miR-320a, miR-622, and miR-429" -target gene hsa-mir-429 MALT Lymphoma 29788729 "the TF MYC was a co-target of miR-320a, miR-622, and miR-429" -target gene hsa-mir-622 MALT Lymphoma 29788729 "the TF MYC was a co-target of miR-320a, miR-622, and miR-429" -target gene hsa-mir-378 Diabetic Nephropathy 29792879 Astragaloside suppresses apoptosis of the podocytes in rats with diabetic nephropathy via miR-378/TRAF5 signaling pathway. -target gene hsa-mir-20a Toxoplasma gondii Infection 29800695 miR-20a inhibition using locked nucleic acid (LNA) technology and its effects on apoptosis of human macrophages infected by Toxoplasma gondii RH strain. -target gene hsa-mir-505 "Carcinoma, Hepatocellular" 29803174 miR-505 enhances doxorubicin-induced cytotoxicity in hepatocellular carcinoma through repressing the Akt pathway by directly targeting HMGB1. -target gene hsa-mir-155 Atherosclerosis 29803178 MiR-155 inhibits transformation of macrophages into foam cells via regulating CEH expression. -target gene hsa-mir-320a "Carcinoma, Lung, Non-Small-Cell" 29803922 MiR-320a-3p/ELF3 axis regulates cell metastasis and invasion in non-small cell lung cancer via PI3K/Akt pathway. -target gene hsa-mir-33a "Squamous Cell Carcinoma, Tongue" 29804249 Long non-coding RNA CASC15 promotes tongue squamous carcinoma progression through targeting miR-33a-5p. -target gene hsa-mir-124 Congenital Hypothyroidism 29805523 microRNA-124-3p inhibits the progression of congenital hypothyroidism via targeting programmed cell death protein 6. -target gene hsa-mir-128 "Carcinoma, Pancreatic" 29805525 miR-128 induces pancreas cancer cell apoptosis by targeting MDM4. -target gene hsa-mir-381 Viral Myocarditis 29805552 MicroRNA-381 protects myocardial cell function in children and mice with viral myocarditis via targeting cyclooxygenase-2 expression. -target gene hsa-mir-206 Prostate Neoplasms 29805562 MicroRNA-206 regulates the epithelial-mesenchymal transition and inhibits the invasion and metastasis of prostate cancer cells by targeting Annexin A2. -target gene hsa-mir-100 Nasopharyngeal Neoplasms 29805566 miR-100 inhibits the migration and invasion of nasopharyngeal carcinoma by targeting IGF1R. -target gene hsa-mir-23a Gastric Neoplasms 29805579 microRNA-23a promotes cell growth and metastasis in gastric cancer via targeting SPRY2-mediated ERK signaling. -target gene hsa-mir-128 Osteosarcoma 29805606 Regulatory mechanism of microRNA-128 in osteosarcoma tumorigenesis and evolution through targeting SASH1. -target gene hsa-mir-126 Prostate Neoplasms 29805636 MicroRNA-126 inhibits proliferation and metastasis in prostate cancer via regulation of ADAM9. -target gene hsa-mir-3160 Prostate Neoplasms 29805667 Prostate cancer cell proliferation is suppressed by microRNA-3160-5p via targeting of F-box and WD repeat domain containing 8. -target gene hsa-mir-206 Ovarian Neoplasms 29807226 MiR-206 inhibits epithelial ovarian cancer cells growth and invasion via blocking c-Met/AKT/mTOR signaling pathway. -target gene hsa-mir-155 Lichen Planus 29813046 MicroRNA Microarray-Based Identification of Involvement of miR-155 and miR-19a in Development of Oral Lichen Planus (OLP) by Modulating Th1/Th2 Balance via Targeting eNOS and Toll-Like Receptor 2 (TLR2). -target gene hsa-mir-19a Lichen Planus 29813046 MicroRNA Microarray-Based Identification of Involvement of miR-155 and miR-19a in Development of Oral Lichen Planus (OLP) by Modulating Th1/Th2 Balance via Targeting eNOS and Toll-Like Receptor 2 (TLR2). -target gene hsa-mir-4497 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 29843929 MicroRNA-4497 functions as a tumor suppressor in laryngeal squamous cell carcinoma via negatively modulation the GBX2. -target gene hsa-mir-148b Wound Healing 29843955 MicroRNA-148b Targets the TGF-¦Â Pathway to Regulate Angiogenesis and Endothelial-to-Mesenchymal Transition during Skin Wound Healing. -target gene hsa-mir-181a Osteoporosis 29845202 Regulatory effects of miRNA?181a on FasL expression in bone marrow mesenchymal stem cells and its effect on CD4+T lymphocyte apoptosis in estrogen deficiency?induced osteoporosis. -target gene hsa-mir-148a Endometriosis 29845209 G protein?coupled estrogen receptor/miR?148a/human leukocyte antigen?G signaling pathway mediates cell apoptosis of ovarian endometriosis. -target gene hsa-mir-215 Endometrial Neoplasms 29845221 miR?215 promotes epithelial to mesenchymal transition and proliferation by regulating LEFTY2 in endometrial cancer. -target gene hsa-mir-449a "Squamous Cell Carcinoma, Esophageal" 29845226 Downregulation of microRNA?449a?5p promotes esophageal squamous cell carcinoma cell proliferation via cyclin D1 regulation. -target gene hsa-mir-19b Melanoma 29845233 Matrine exerts inhibitory effects in melanoma through the regulation of miR-19b-3p/PTEN. -target gene hsa-mir-1 Colon Neoplasms 29845255 miR?1 inhibits the progression of colon cancer by regulating the expression of vascular endothelial growth factor. -target gene hsa-mir-23a Sepsis 29845275 miR?23a downregulation modulates the inflammatory response by targeting ATG12?mediated autophagy. -target gene hsa-mir-183 Osteosarcoma 29845278 Baicalein inhibits osteosarcoma cell proliferation and invasion through the miR?183/Ezrin pathway. -target gene hsa-mir-613 Osteosarcoma 29845707 CXCR4-mediated osteosarcoma growth and pulmonary metastasis is suppressed by MicroRNA-613. -target gene hsa-mir-193a Gastric Neoplasms 29848678 MiR-193a-5p and -3p Play a Distinct Role in Gastric Cancer: miR-193a-3p Suppresses Gastric Cancer Cell Growth by Targeting ETS1 and CCND1. -target gene hsa-mir-203 Oral Neoplasms 29848700 MicroRNA-203 Induces Apoptosis by Targeting Bmi-1 in YD-38 Oral Cancer Cells. -target gene hsa-mir-204 Arterial Calcification of Infancy 29850805 Arterial Calcification Is Regulated Via an miR-204/DNMT3a Regulatory Circuit Both In Vitro and in Female Mice. -target gene hsa-mir-497 Ischemia-Reperfusion Injury 29852387 MicroRNA-497 promotes proliferation and inhibits apoptosis of cardiomyocytes through the downregulation of Mfn2 in a mouse model of myocardial ischemia-reperfusion injury. -target gene hsa-mir-124 Lichen Planus 29852392 Total glucosides of paeony improves the immunomodulatory capacity of MSCs partially via the miR-124/STAT3 pathway in oral lichen planus. -target gene hsa-mir-143 Myocardial Infarction 29858017 By Targeting Atg7 MicroRNA-143 Mediates Oxidative Stress-Induced Autophagy of c-Kit+ Mouse Cardiac Progenitor Cells. -target gene hsa-mir-106a Osteoarthritis 29858052 Cryptotanshinone Protects Cartilage against Developing Osteoarthritis through the miR-106a-5p/GLIS3 Axis. -target gene hsa-mir-411 "Carcinoma, Bladder" 29858066 MicroRNA-411 Downregulation Enhances Tumor Growth by Upregulating MLLT11 Expression in Human Bladder Cancer. -target gene hsa-mir-199a "Carcinoma, Hepatocellular" 29858083 miR-199a-3p Modulates MTOR and PAK4 Pathways and Inhibits Tumor Growth in a Hepatocellular Carcinoma Transgenic Mouse Model. -target gene hsa-mir-27b Ocular Motility Disease 29858119 Down-regulation of microRNA-27b promotes retinal pigment epithelial cell proliferation and migration by targeting Nox2. -target gene hsa-mir-365 Melanoma 29858490 MicroRNA-365 Inhibits Cell Growth and Promotes Apoptosis in Melanoma by Targeting BCL2 and Cyclin D1 (CCND1). -target gene hsa-mir-487a "Diabetes Mellitus, Type 1" 29859273 miR-487a-3p upregulated in type 1 diabetes targets CTLA4 and FOXO3. -target gene hsa-mir-1179 "Carcinoma, Pancreatic" 29859832 "MicroRNA-1179 inhibits the proliferation, migration and invasion of human pancreatic cancer cells by targeting E2F5." -target gene hsa-mir-18a Lung Neoplasms 29860718 Radiosensitizing effects of miR-18a-5p on lung cancer stem-like cells via downregulating both ATM and HIF-1¦Á. -target gene hsa-mir-19 "Carcinoma, Breast" 29864457 miR-19 targeting of PTEN mediates butyl benzyl phthalate-induced proliferation in both ER(+) and ER(-) breast cancer cells. -target gene hsa-mir-214 "Squamous Cell Carcinoma, Esophageal" 29864623 MiR-214 promotes cell meastasis and inhibites apoptosis of esophageal squamous cell carcinoma via PI3K/AKT/mTOR signaling pathway. -target gene hsa-mir-196b Gastric Neoplasms 29864624 MicroRNA-196b enhances the radiosensitivity of SNU-638 gastric cancer cells by targeting RAD23B. -target gene hsa-mir-876 Psoriasis 29864894 MiR-876-5p suppresses cell proliferation by targeting Angiopoietin-1 in the psoriasis. -target gene hsa-mir-125b "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 29864898 MiR-125b-5p suppressed the glycolysis of laryngeal squamous cell carcinoma by down-regulating hexokinase-2. -target gene hsa-mir-23a Pulmonary Hypertension 29864909 MiR-23a regulates the proliferation and migration of human pulmonary artery smooth muscle cells (HPASMCs) through targeting BMPR2/Smad1 signaling. -target gene hsa-mir-101 Endometrial Neoplasms 29864910 Berberine suppresses growth and metastasis of endometrial cancer cells via miR-101/COX-2. -target gene hsa-mir-129 Neuroblastoma 29864913 miR-129 inhibits tumor growth and potentiates chemosensitivity of neuroblastoma by targeting MYO10. -target gene hsa-mir-20a "Carcinoma, Breast, Triple Negative" 29864933 MiRNA-20a-5p promotes the growth of triple-negative breast cancer cells through targeting RUNX3. -target gene hsa-mir-200b Metabolic Syndrome 29864940 MicroRNA-200b regulates preadipocyte proliferation and differentiation by targeting KLF4. -target gene hsa-mir-300 "Carcinoma, Hepatocellular" 29864952 miR-300 regulates the epithelial-mesenchymal transition and invasion of hepatocellular carcinoma by targeting the FAK/PI3K/AKT signaling pathway. -target gene hsa-mir-140 Cardiovascular Diseases [unspecific] 29864954 miR-140-5p aggravates hypoxia-induced cell injury via regulating MLK3 in H9c2 cells. -target gene hsa-mir-199a Osteosarcoma 29866054 MiR-199a-3p affects the multi-chemoresistance of osteosarcoma through targeting AK4. -target gene hsa-mir-363 "Adenocarcinoma, Cervical" 29871972 MiR-362-3p functions as a tumor suppressor through targeting MCM5 in cervical adenocarcinoma. -target gene hsa-mir-1247 "Carcinoma, Bladder" 29872024 Inhibition of miR-1247 on cell proliferation and invasion in bladder cancer through its downstream target of RAB36. -target gene hsa-mir-154 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 29874469 MiR-154 inhibits the growth of laryngeal squamous cell carcinoma by targeting the GALNT7. -target gene hsa-mir-17 Sciatic Nerve Injury 29877111 PEITC promotes neurite growth in primary sensory neurons via the miR-17-5p/STAT3/GAP-43 axis. -target gene hsa-mir-129 Gastric Neoplasms 29879625 MiR-129-5p functions as a tumor suppressor in gastric cancer progression through targeting ADAM9. -target gene hsa-mir-21 Periodontitis 29884447 MicroRNA-21 down-regulates inflammation and inhibits periodontitis. -target gene hsa-mir-1 "Cardiomyopathy, Hypertrophic" 29885652 Clcn3 as a direct target of miR-1-3p which sheds light on the mechanism of HCM -target gene hsa-mir-125a "Adenocarcinoma, Esophageal" 29885883 "microRNA 125a Regulates MHC-I Expression on Esophageal Adenocarcinoma Cells, Associated With Suppression of Antitumor Immune Response and Poor Outcomes of Patients." -target gene hsa-mir-206 "Carcinoma, Breast" 29886033 Down-regulation of NAMPT expression by mir-206 reduces cell survival of breast cancer cells. -target gene hsa-mir-20a Skin Disease [unspecific] 29886071 MiR-20a-3p regulates TGF-¦Â1/Survivin pathway to affect keratinocytes proliferation and apoptosis by targeting SFMBT1 in vitro. -target gene hsa-mir-208a Gastric Neoplasms 29886152 MiR-208a enhances cell proliferation and invasion of gastric cancer by targeting SFRP1 and negatively regulating MEG3. -target gene hsa-mir-199a "Leukemia, Myeloid, Chronic" 29890129 microRNA-199a/b-5p enhance imatinib efficacy via repressing WNT2 signaling-mediated protective autophagy in imatinib-resistant chronic myeloid leukemia cells. -target gene hsa-mir-199b "Leukemia, Myeloid, Chronic" 29890129 microRNA-199a/b-5p enhance imatinib efficacy via repressing WNT2 signaling-mediated protective autophagy in imatinib-resistant chronic myeloid leukemia cells. -target gene hsa-mir-873 Esophageal Neoplasms 29890466 MicroRNA-873 acts as a tumor suppressor in esophageal cancer by inhibiting differentiated embryonic chondrocyte expressed gene 2. -target gene hsa-mir-3200 Osteosarcoma 29890825 MicroRNA-3200-5p Promotes Osteosarcoma Cell Invasion via Suppression of BRMS1. -target gene hsa-mir-744 Ovarian Neoplasms 29899543 MiR-744-5p inducing cell death by directly targeting HNRNPC and NFIX in ovarian cancer cells. -target gene hsa-mir-30a Melanoma 29901141 "miR?30a?5p inhibits the proliferation, migration and invasion of melanoma cells by targeting SOX4." -target gene hsa-mir-125b Alzheimer Disease 29901156 MicroRNA?125b regulates Alzheimer's disease through SphK1 regulation. -target gene hsa-mir-23b "Carcinoma, Hepatocellular" 29901200 miR?23b inhibits proliferation of SMMC?7721 cells by directly targeting IL?11. -target gene hsa-mir-142 Ovarian Neoplasms 29904404 MicroRNA-142-3p inhibits cell proliferation and chemoresistance in ovarian cancer via targeting sirtuin 1. -target gene hsa-mir-106b Cholesteatoma 29905392 Down-regulation of exosomal miR-106b-5p derived from cholesteatoma perimatrix fibroblasts promotes angiogenesis in endothelial cells by overexpression of Angiopoietin 2. -target gene hsa-mir-149 Diabetes Mellitus 29905828 miR-149 negative regulation of mafA is involved in the arsenite-induced dysfunction of insulin synthesis and secretion in pancreatic beta cells. -target gene hsa-mir-145 Idiopathic Scoliosis 29906249 Aberrant miR-145-5p/¦Â-catenin signal impairs osteocyte function in adolescent idiopathic scoliosis. -target gene hsa-mir-302c Colorectal Carcinoma 29906744 MicroRNA-302c represses epithelial-mesenchymal transition and metastasis by targeting transcription factor AP-4 in colorectal cancer. -target gene hsa-mir-30 Neoplasms [unspecific] 29907771 miR-30 disrupts senescence and promotes cancer by targeting both p16INK4A and DNA damage pathways. -target gene hsa-mir-181a Myocardial Infarction 29908129 upregulation of miR-181a suppressed the expression of TGF-¦Â receptor III (T¦ÂRIII) by binding with 3'-UTR -target gene hsa-mir-499a Glioma 29908894 MicroRNA-499a decelerates glioma cell proliferation while accelerating apoptosis through the suppression of Notch1 and the MAPK signaling pathway. -target gene hsa-mir-590 Crohn Disease 29912317 MicroRNA-590-5p Inhibits Intestinal Inflammation by Targeting YAP. -target gene hsa-mir-146a "Carcinoma, Breast" 29915929 Identification of miR-146a is Associated with the Aggressiveness and Suppresses Proliferation via Targeting CDKN2A in Breast Cancer. -target gene hsa-mir-590 Osteosarcoma 29916536 miR?590?5p suppresses osteosarcoma cell proliferation and invasion via targeting KLF5. -target gene hsa-mir-1297 "Carcinoma, Cervical" 29916735 MicroRNA-1297 contributes to the progression of human cervical carcinoma through PTEN. -target gene hsa-mir-324 Polycystic Ovarian Syndrome 29917177 The role of MiR-324-3p in polycystic ovary syndrome (PCOS) via targeting WNT2B. -target gene hsa-mir-148a Glioblastoma 29921422 Exosomes of glioma cells deliver miR-148a to promote proliferation and metastasis of glioblastoma via targeting CADM1. -target gene hsa-mir-370 "Adenocarcinoma, Colon" 29922946 Hsa-miR-370 inhibited P-selectin-induced cell adhesion in human colon adenocarcinoma cells. -target gene hsa-mir-96 "Carcinoma, Bladder" 29923283 miR-96 regulates migration and invasion of bladder cancer through epithelial-mesenchymal transition in response to transforming growth factor-¦Â1. -target gene hsa-mir-182 "Carcinoma, Breast" 29925897 miR-182 regulates trastuzumab resistance by targeting MET in breast cancer cells. -target gene hsa-mir-197 "Carcinoma, Cervical" 29928375 miR-197 is downregulated in cervical carcinogenesis and suppresses cell proliferation and invasion through targeting forkhead box M1. -target gene hsa-mir-216b "Carcinoma, Lung, Non-Small-Cell" 29928377 MicroRNA-216b regulated proliferation and invasion of non-small cell lung cancer by targeting SOX9. -target gene hsa-mir-154 "Carcinoma, Lung, Non-Small-Cell" 29928380 MicroRNA-154 functions as a tumor suppressor in non-small cell lung cancer through directly targeting B-cell-specific Moloney murine leukemia virus insertion site 1. -target gene hsa-mir-423 Glioma 29928399 MicroRNA-423-3p promotes glioma growth by targeting PANX2. -target gene hsa-mir-196b Lung Neoplasms 29928408 miR-196b promotes lung cancer cell migration and invasion through the targeting of GATA6. -target gene hsa-mir-449c Gastric Neoplasms 29928430 miR-449c inhibits migration and invasion of gastric cancer cells by targeting PFKFB3. -target gene hsa-mir-409 "Squamous Cell Carcinoma, Tongue" 29928443 "miR-409-3p suppresses the proliferation, invasion and migration of tongue squamous cell carcinoma via targeting RDX." -target gene hsa-mir-455 "Carcinoma, Renal Cell" 29928475 Anti-tumor roles of both strands of the miR-455 duplex: their targets SKA1 and SKA3 are involved in the pathogenesis of renal cell carcinoma. -target gene hsa-mir-146a Lung Neoplasms 29928483 miR-146a suppresses 5-lipoxygenase activating protein (FLAP) expression and Leukotriene B4 production in lung cancer cells. -target gene hsa-mir-26a Acute Kidney Failure 29932234 miR-26a modulates HGF and STAT3 effects on the kidney repair process in a glycerol-induced AKI model in rats. -target gene hsa-mir-455 Diabetic Nephropathy 29932921 MiR-455-3p suppresses renal fibrosis through repression of ROCK2 expression in diabetic nephropathy. -target gene hsa-mir-16 "Carcinoma, Hepatocellular" 29935185 Inhibition of microRNA-16 facilitates the paclitaxel resistance by targeting IKBKB via NF-¦ÊB signaling pathway in hepatocellular carcinoma. -target gene hsa-mir-17 Neoplasms [unspecific] 29935344 MicroRNAs of miR-17-92 cluster increase gene expression by targeting mRNA-destabilization pathways. -target gene hsa-mir-18 Neoplasms [unspecific] 29935344 MicroRNAs of miR-17-92 cluster increase gene expression by targeting mRNA-destabilization pathways. -target gene hsa-mir-19a Neoplasms [unspecific] 29935344 MicroRNAs of miR-17-92 cluster increase gene expression by targeting mRNA-destabilization pathways. -target gene hsa-mir-19b-1 Neoplasms [unspecific] 29935344 MicroRNAs of miR-17-92 cluster increase gene expression by targeting mRNA-destabilization pathways. -target gene hsa-mir-20a Neoplasms [unspecific] 29935344 MicroRNAs of miR-17-92 cluster increase gene expression by targeting mRNA-destabilization pathways. -target gene hsa-mir-92-1 Neoplasms [unspecific] 29935344 MicroRNAs of miR-17-92 cluster increase gene expression by targeting mRNA-destabilization pathways. -target gene hsa-mir-340 "Carcinoma, Lung, Non-Small-Cell" 29935356 Lower miR-340 expression predicts poor prognosis of non-small cell lung cancer and promotes cell proliferation by targeting CDK4. -target gene hsa-mir-30a Osteosarcoma 29936179 MiR-30a-5p inhibits c cell proliferation and migration by targeting FOXD1. -target gene hsa-mir-200a Alzheimer Disease 29936262 Modulation in miR-200a/SIRT1axis is associated with apoptosis in MPP+-induced SH-SY5Y cells. -target gene hsa-mir-30a Parkinson Disease 29936662 these DEGs may be regulated by miRNAs of the miR-30 family and TFs STAT1 and GRHL3 -target gene hsa-mir-30b Parkinson Disease 29936662 these DEGs may be regulated by miRNAs of the miR-30 family and TFs STAT1 and GRHL3 -target gene hsa-mir-30c-1 Parkinson Disease 29936662 these DEGs may be regulated by miRNAs of the miR-30 family and TFs STAT1 and GRHL3 -target gene hsa-mir-30c-2 Parkinson Disease 29936662 these DEGs may be regulated by miRNAs of the miR-30 family and TFs STAT1 and GRHL3 -target gene hsa-mir-30d Parkinson Disease 29936662 these DEGs may be regulated by miRNAs of the miR-30 family and TFs STAT1 and GRHL3 -target gene hsa-mir-30e Parkinson Disease 29936662 these DEGs may be regulated by miRNAs of the miR-30 family and TFs STAT1 and GRHL3 -target gene hsa-mir-155 Acute Pancreatitis 29937734 MiRNA-155 Regulates the Th17/Treg Ratio by Targeting SOCS1 in Severe Acute Pancreatitis. -target gene hsa-mir-483 Perlman Syndrome 29939354 IGF2-derived miR-483-3p contributes to macrosomia through regulating trophoblast proliferation by targeting RB1CC1. -target gene hsa-mir-204 Gastric Neoplasms 29940566 Sensitization of Gastric Cancer Cells to 5-FU by MicroRNA-204 Through Targeting the TGFBR2-Mediated Epithelial to Mesenchymal Transition. -target gene hsa-mir-20a Colorectal Carcinoma 29940575 Knockdown of MiR-20a Enhances Sensitivity of Colorectal Cancer Cells to Cisplatin by Increasing ASK1 Expression. -target gene hsa-mir-29b-2 "Adenocarcinoma, Pancreatic Ductal" 29940895 MicroRNA-29b-2-5p inhibits cell proliferation by directly targeting Cbl-b in pancreatic ductal adenocarcinoma. -target gene hsa-mir-126 Diabetes Mellitus 29942117 Icariside II ameliorates endothelial dysfunction by regulating the MAPK pathway via miR-126/SPRED1 in diabetic human cavernous endothelial cells. -target gene hsa-mir-488 "Squamous Cell Carcinoma, Tongue" 29946339 MicroRNA-488 inhibits tongue squamous carcinoma cell invasion and EMT by directly targeting ATF3. -target gene hsa-mir-195 Colon Neoplasms 29948330 MiR-195 suppresses colon cancer proliferation and metastasis by targeting WNT3A. -target gene hsa-mir-199a Spinal Cord Injuries 29948551 Upregulation of miR-199a-5p Protects Spinal Cord Against Ischemia/Reperfusion-Induced Injury via Downregulation of ECE1 in Rat. -target gene hsa-mir-378 Glioma 29949160 "MicroRNA-378 acts as a prognosis marker and inhibits cell migration, invasion and epithelial-mesenchymal transition in human glioma by targeting IRG1." -target gene hsa-mir-592 Gastric Neoplasms 29949784 "MiR-592 Promotes Gastric Cancer Proliferation, Migration, and Invasion Through the PI3K/AKT and MAPK/ERK Signaling Pathways by Targeting Spry2." -target gene hsa-mir-142 Atherosclerosis 29949787 MicroRNA-142-3p Induces Atherosclerosis-Associated Endothelial Cell Apoptosis by Directly Targeting Rictor. -target gene hsa-mir-146b Sepsis 29951922 MiR-146b protect against sepsis induced mice myocardial injury through inhibition of Notch1. -target gene hsa-mir-155 Ischemia-Reperfusion Injury 29951932 minocycline is neuroprotective against ischemic brain injury through their modulation of miR-155-mediated BDNF repression -target gene hsa-mir-351 Ischemia-Reperfusion Injury 29952043 MicroRNA-351-5p aggravates intestinal ischaemia/reperfusion injury through the targeting of MAPK13 and Sirtuin-6. -target gene hsa-mir-26a Idiopathic Pulmonary Fibrosis 29952219 Inhibition of lncRNA PFRL prevents pulmonary fibrosis by disrupting the miR-26a/smad2 loop. -target gene hsa-mir-210 Cholangiocarcinoma 29953500 Potential role of HIF-1-responsive microRNA210/HIF3 axis on gemcitabine resistance in cholangiocarcinoma cells. -target gene hsa-mir-1287 "Carcinoma, Hepatocellular" 29953647 "Mir-1287 suppresses the proliferation, invasion, and migration in hepatocellular carcinoma by targeting PIK3R3." -target gene hsa-mir-146a Liver Fibrosis 29953648 microRNA-146a is involved in rSjP40-inhibited activation of LX-2 cells by targeting Smad4 expression. -target gene hsa-mir-34a Liver Fibrosis 29957876 MicroRNA-34a-5p inhibits liver fibrosis by regulating TGF-¦Â1/Smad3 pathway in hepatic stellate cells. -target gene hsa-mir-9 "Carcinoma, Head And Neck" 29959873 "MicroRNA-9 inhibits growth and invasion of head and neck cancer cells and is a predictive biomarker of response to plerixafor, an inhibitor of its target CXCR4." -target gene hsa-mir-320 Diabetes Mellitus 29960867 miR-320 mediates diabetes amelioration after duodenal-jejunal bypass via targeting adipoR1. -target gene hsa-mir-135 "Squamous Cell Carcinoma, Esophageal" 29961392 miR-135 promotes proliferation and stemness of oesophageal squamous cell carcinoma by targeting RERG. -target gene hsa-mir-15b Alzheimer Disease 29961672 miR-15b Reduces Amyloid-¦Â Accumulation in SH-SY5Y Cell Line through Targeting NF-¦ÊB signaling and BACE1. -target gene hsa-mir-20a Multiple Myeloma 29963125 "Effects of microRNA-20a on the proliferation, migration and apoptosis of multiple myeloma via the PTEN/PI3K/AKT signaling pathway." -target gene hsa-mir-139 Prostate Neoplasms 29963147 MicroRNA-139-5P inhibits human prostate cancer cell proliferation by targeting Notch1. -target gene hsa-mir-222 "Carcinoma, Ovarian" 29963173 miR-222 promotes invasion and migration of ovarian carcinoma by targeting PTEN. -target gene hsa-mir-599 Glioma 29963197 MicroRNA-599 suppresses glioma progression by targeting RAB27B. -target gene hsa-mir-328 "Carcinoma, Breast, Triple Negative" 29964098 Dihydrotestosterone regulates expression of CD44 via miR-328-3p in triple-negative breast cancer cells. -target gene hsa-mir-144 "Carcinoma, Renal Cell" 29968393 Regulation of antitumor miR-144-5p targets oncogenes: Direct regulation of syndecan-3 and its clinical significance. -target gene hsa-mir-760 "Carcinoma, Hepatocellular" 29968951 MicroRNA-760 Inhibits Doxorubicin Resistance in Hepatocellular Carcinoma through Regulating Notch1/Hes1-PTEN/Akt Signaling Pathway. -target gene hsa-mir-31 Melanoma 29969627 The miR-31-SOX10 axis regulates tumor growth and chemotherapy resistance of melanoma via PI3K/AKT pathway. -target gene hsa-mir-500a "Carcinoma, Hepatocellular" 29969781 MicroRNA-500a Promotes the Progression of Hepatocellular Carcinoma by Post-Transcriptionally Targeting BID. -target gene hsa-mir-98 "Adenocarcinoma, Pancreatic Ductal" 29970191 Downregulated miR-98-5p promotes PDAC proliferation and metastasis by reversely regulating MAP4K4. -target gene hsa-mir-378 Melanoma 29972255 MicroRNA-378 regulates epithelial-mesenchymal transition and metastasis of melanoma by inhibiting FOXN3 expression through the Wnt/¦Â-catenin pathway. -target gene hsa-mir-203a Gastric Neoplasms 29973668 MiR-99b-5p and miR-203a-3p Function as Tumor Suppressors by Targeting IGF-1R in Gastric Cancer. -target gene hsa-mir-99b Gastric Neoplasms 29973668 MiR-99b-5p and miR-203a-3p Function as Tumor Suppressors by Targeting IGF-1R in Gastric Cancer. -target gene hsa-let-7a Atopic Dermatitis 29974487 "Hsa-let-7a-5p may target CCR7, and hsa-miR-26a-5p probably targets HAS3" -target gene hsa-mir-26a Atopic Dermatitis 29974487 "Hsa-let-7a-5p may target CCR7, and hsa-miR-26a-5p probably targets HAS3" -target gene hsa-mir-106b "Carcinoma, Hepatocellular" 29975452 MiR-106b regulates the apoptosis and tumorigenesis of hepatocellular carcinoma via targeting Zinc finger and BTB domain-containing protein 7A (Zbtb7a). -target gene hsa-mir-137 "Carcinoma, Breast, Triple Negative" 29975921 MiR-137 Suppresses Triple-Negative Breast Cancer Stemness and Tumorigenesis by Perturbing BCL11A-DNMT1 Interaction. -target gene hsa-mir-424 "Carcinoma, Hepatocellular" 29975928 "Focusing on the new insight of the PVT1/miR-424-5p/INCENP axis, this study provides a novel perspective for HCC therapeutic strategies" -target gene hsa-mir-100 "Carcinoma, Breast" 29975932 miR-100 Reverses Cisplatin Resistance in Breast Cancer by Suppressing HAX-1. -target gene hsa-mir-711 Kaposi Sarcoma 29976660 Upregulation of MicroRNA 711 Mediates HIV-1 Vpr Promotion of Kaposi's Sarcoma-Associated Herpesvirus Latency and Induction of Pro-proliferation and Pro-survival Cytokines by Targeting the Notch/NF-¦ÊB-Signaling Axis. -target gene hsa-mir-103 Atherosclerosis 29980665 miR-103 promotes endothelial maladaptation by targeting lncWDR59. -target gene hsa-mir-340 Age-Related Macular Degeneration 29982095 MiR-340/iASPP axis affects UVB-mediated retinal pigment epithelium (RPE) cell damage. -target gene hsa-mir-92a Osteosarcoma 29984257 MiR-92a Inhibits the Progress of Osteosarcoma Cells and Increases the Cisplatin Sensitivity by Targeting Notch1. -target gene hsa-mir-498 "Carcinoma, Breast" 29985991 MicroRNA-498 promotes proliferation and migration by targeting the tumor suppressor PTEN in breast cancer cells. -target gene hsa-mir-124 "Adenocarcinoma, Pancreatic Ductal" 29988949 Involvement of anti-tumor miR-124-3p and its targets in the pathogenesis of pancreatic ductal adenocarcinoma: direct regulation of ITGA3 and ITGB1 by miR-124-3p. -target gene hsa-mir-146a Infection [unspecific] 29990507 MiR-146a-3p and miR-216a-5p inhibited the expression of type-I IFN and the Mx1 gene induced by IHNV -target gene hsa-mir-216a Infection [unspecific] 29990507 MiR-146a-3p and miR-216a-5p inhibited the expression of type-I IFN and the Mx1 gene induced by IHNV -target gene hsa-mir-193b Liver Injury 29990747 MicroRNA-193b-3p regulates hepatocyte apoptosis in selenium-deficient broilers by targeting MAML1. -target gene hsa-mir-298 "Carcinoma, Hepatocellular" 29990836 MicroRNA-298 represses hepatocellular carcinoma progression by inhibiting CTNND1-mediated Wnt/¦Â-catenin signaling. -target gene hsa-mir-218 "Squamous Cell Carcinoma, Oral" 29990854 Downregulation of miR-218-5p promotes invasion of oral squamous cell carcinoma cells via activation of CD44-ROCK signaling. -target gene hsa-mir-34a Osteosarcoma 29991717 miR-34a exerts as a key regulator in the dedifferentiation of osteosarcoma via PAI-1-Sox2 axis. -target gene hsa-mir-223 Osteosarcoma 29991755 "miR-223-5p/(CLSTN2, AC009951.1, LINC01705, AC090673.1), miR-378b/(ALX4, IGSF3, SULF1), and miR-323b-3p/TGFBR3 were involved in both tumorigenesis and pulmonary metastasis of OS." -target gene hsa-mir-323b Osteosarcoma 29991755 "miR-223-5p/(CLSTN2, AC009951.1, LINC01705, AC090673.1), miR-378b/(ALX4, IGSF3, SULF1), and miR-323b-3p/TGFBR3 were involved in both tumorigenesis and pulmonary metastasis of OS." -target gene hsa-mir-378b Osteosarcoma 29991755 "miR-223-5p/(CLSTN2, AC009951.1, LINC01705, AC090673.1), miR-378b/(ALX4, IGSF3, SULF1), and miR-323b-3p/TGFBR3 were involved in both tumorigenesis and pulmonary metastasis of OS." -target gene hsa-mir-186 Alzheimer Disease 29995978 Effect of microRNA-186 on oxidative stress injury of neuron by targeting interleukin 2 through the janus kinase-signal transducer and activator of transcription pathway in a rat model of Alzheimer's disease. -target gene hsa-mir-150 Osteoarthritis 29996115 Down-Regulation of MiR-150 Alleviates Inflammatory Injury Induced by Interleukin 1 via Targeting Kruppel-Like Factor 2 in Human Chondrogenic Cells. -target gene hsa-mir-17 Prostate Neoplasms 30001402 The deregulation of miR-17/CCND1 axis during neuroendocrine transdifferentiation of LNCaP prostate cancer cells. -target gene hsa-mir-34a "Carcinoma, Bladder" 30001529 MicroRNA-34a Attenuates Metastasis and Chemoresistance of Bladder Cancer Cells by Targeting the TCF1/LEF1 Axis. -target gene hsa-mir-135b Cerebral Ischemia 30002689 MicroRNA-135b-5p prevents oxygen-glucose deprivation and reoxygenation-induced neuronal injury through regulation of the GSK-3¦Â/Nrf2/ARE signaling pathway. -target gene hsa-mir-181b "Carcinoma, Lung, Small-Cell" 30002690 miR-181b inhibits chemoresistance in cisplatin-resistant H446 small cell lung cancer cells by targeting Bcl-2. -target gene hsa-mir-874 Ovarian Neoplasms 30004169 Upregulation of miR-874-3p and miR-874-5p inhibits epithelial ovarian cancer malignancy via SIK2. -target gene hsa-mir-6126 Hepatitis B Virus Infection 30004437 miR-6126 was able to suppress HBsAg production and HBV replication -target gene hsa-mir-34a Fatty Liver [unspecific] 30006135 Ablation of carotenoid cleavage enzymes (BCO1 and BCO2) induced hepatic steatosis by altering the farnesoid X receptor/miR-34a/sirtuin 1 pathway. -target gene hsa-mir-9 "Carcinoma, Hepatocellular" 30006781 "miR-9 inhibits the metastatic ability of hepatocellular carcinoma via targeting beta galactoside alpha-2,6-sialyltransferase 1." -target gene hsa-mir-15a Diabetes Mellitus 30007975 "experiments in MIN6 cells illustrated that miR-15a, miR-424, miR-497, and miR-185 positively regulated insulin biosynthesis by co-inhibiting UCP2 expression" -target gene hsa-mir-185 Diabetes Mellitus 30007975 "experiments in MIN6 cells illustrated that miR-15a, miR-424, miR-497, and miR-185 positively regulated insulin biosynthesis by co-inhibiting UCP2 expression" -target gene hsa-mir-424 Diabetes Mellitus 30007975 "experiments in MIN6 cells illustrated that miR-15a, miR-424, miR-497, and miR-185 positively regulated insulin biosynthesis by co-inhibiting UCP2 expression" -target gene hsa-mir-497 Diabetes Mellitus 30007975 "experiments in MIN6 cells illustrated that miR-15a, miR-424, miR-497, and miR-185 positively regulated insulin biosynthesis by co-inhibiting UCP2 expression" -target gene hsa-mir-204 Glioblastoma 30008822 "miR-204 functions as a tumor suppressor gene, at least partly by suppressing CYP27A1 in glioblastoma." -target gene hsa-mir-29c Liver Neoplasms 30008835 MicroRNA-29c restores cisplatin sensitivity in liver cancer through direct inhibition of sirtuin 1 expression. -target gene hsa-mir-205 "Carcinoma, Hepatocellular" 30008920 MicroRNA-205 is downregulated in hepatocellular carcinoma and inhibits cell growth and metastasis via directly targeting vascular endothelial growth factor A. -target gene hsa-mir-210 Osteosarcoma 30008923 miR-210 promotes human osteosarcoma cell migration and invasion by targeting FGFRL1. -target gene hsa-mir-650 Colorectal Carcinoma 30008936 MicroRNA-650 targets inhibitor of growth 4 to promote colorectal cancer progression via mitogen activated protein kinase signaling. -target gene hsa-mir-155 Gastric Neoplasms 30008945 Mitogen-activated protein kinase kinase kinase 10 was demonstrated to be a potential target gene of miR-155-5p -target gene hsa-mir-638 Glioma 30010402 hsa_circ_0000177-miR-638-FZD7-Wnt Signaling Cascade Contributes to the Malignant Behaviors in Glioma. -target gene hsa-mir-106a Colorectal Carcinoma 30011263 miR-106a Reduces 5-Fluorouracil (5-FU) Sensitivity of Colorectal Cancer by Targeting Dual-Specificity Phosphatases 2 (DUSP2). -target gene hsa-mir-27b "Carcinoma, Breast" 30012170 Suppression of PDHX by microRNA-27b deregulates cell metabolism and promotes growth in breast cancer. -target gene hsa-mir-589 Gastric Neoplasms 30012200 miR-589 promotes gastric cancer aggressiveness by a LIFR-PI3K/AKT-c-Jun regulatory feedback loop. -target gene hsa-mir-340 Psoriasis 30012847 miR-340 Alleviates Psoriasis in Mice through Direct Targeting of IL-17A. -target gene hsa-mir-488 Osteosarcoma 30015825 "MicroRNA-488 inhibits proliferation, invasion and EMT in osteosarcoma cell lines by targeting aquaporin 3." -target gene hsa-mir-655 "Squamous Cell Carcinoma, Oral" 30015840 MicroRNA?655 suppresses cell proliferation and invasion in oral squamous cell carcinoma by directly targeting metadherin and regulating the PTEN/AKT pathway. -target gene hsa-mir-199a Testicular Neoplasms 30015851 miR?199a?3p/Sp1/LDHA axis controls aerobic glycolysis in testicular tumor cells. -target gene hsa-mir-665 Ovarian Neoplasms 30015865 MicroRNA?665 suppresses the growth and migration of ovarian cancer cells by targeting HOXA10. -target gene hsa-mir-155 "Carcinoma, Breast" 30015868 NT21MP negatively regulates paclitaxel-resistant cells by targeting miR?155?3p and miR?155-5p via the CXCR4 pathway in breast cancer. -target gene hsa-mir-577 "Carcinoma, Lung, Non-Small-Cell" 30015869 miR-577 suppresses cell proliferation and epithelial-mesenchymal transition by regulating the WNT2B mediated Wnt/¦Â-catenin pathway in non-small cell lung cancer. -target gene hsa-mir-200b Colorectal Carcinoma 30015876 miR?200b?3p inhibits proliferation and induces apoptosis in colorectal cancer by targeting Wnt1. -target gene hsa-mir-500a Glioblastoma 30015879 "MiR?500a?5p promotes glioblastoma cell proliferation, migration and invasion by targeting chromodomain helicase DNA binding protein 5." -target gene hsa-mir-155 Atherosclerosis 30015881 MicroRNA?155 promotes ox?LDL?induced autophagy in human umbilical vein endothelial cells by targeting the PI3K/Akt/mTOR pathway. -target gene hsa-mir-185 "Carcinoma, Breast" 30015912 miR?185?5p inhibits F?actin polymerization and reverses epithelial mesenchymal transition of human breast cancer cells by modulating RAGE. -target gene hsa-mir-218 Osteoporosis 30016774 MicroRNA-218 Negatively Regulates Osteoclastogenic Differentiation by Repressing the Nuclear Factor-¦ÊB Signaling Pathway and Targeting Tumor Necrosis Factor Receptor 1. -target gene hsa-mir-410 "Carcinoma, Breast" 30016800 MiR-410 Acts as a Tumor Suppressor in Estrogen Receptor-Positive Breast Cancer Cells by Directly Targeting ERLIN2 via the ERS Pathway. -target gene hsa-mir-148a Thyroid Neoplasms 30018720 PKM2 functions as a potential oncogene and is a crucial target of miR-148a and miR-326 in thyroid tumorigenesis. -target gene hsa-mir-326 Thyroid Neoplasms 30018720 PKM2 functions as a potential oncogene and is a crucial target of miR-148a and miR-326 in thyroid tumorigenesis. -target gene hsa-mir-92a-1 Bone Disease [unspecific] 30019248 MicroRNA-92a-1-5p influences osteogenic differentiation of MC3T3-E1 cells by regulating ¦Â-catenin. -target gene hsa-mir-335 Ovarian Neoplasms 30019389 MiR-335-5p restores cisplatin sensitivity in ovarian cancer cells through targeting BCL2L2. -target gene hsa-mir-153 "Carcinoma, Endometrial" 30019459 "miRNAs,including miR-182, miR-183, miR-153, miR-27a, and miR-96, were predicted to bind LINC00261 and FOXO1, and functioned to attenuate expression of LINC00261 and FOXO1" -target gene hsa-mir-182 "Carcinoma, Endometrial" 30019459 "miRNAs,including miR-182, miR-183, miR-153, miR-27a, and miR-96, were predicted to bind LINC00261 and FOXO1, and functioned to attenuate expression of LINC00261 and FOXO1" -target gene hsa-mir-183 "Carcinoma, Endometrial" 30019459 "miRNAs,including miR-182, miR-183, miR-153, miR-27a, and miR-96, were predicted to bind LINC00261 and FOXO1, and functioned to attenuate expression of LINC00261 and FOXO1" -target gene hsa-mir-27a "Carcinoma, Endometrial" 30019459 "miRNAs,including miR-182, miR-183, miR-153, miR-27a, and miR-96, were predicted to bind LINC00261 and FOXO1, and functioned to attenuate expression of LINC00261 and FOXO1" -target gene hsa-mir-96 "Carcinoma, Endometrial" 30019459 "miRNAs,including miR-182, miR-183, miR-153, miR-27a, and miR-96, were predicted to bind LINC00261 and FOXO1, and functioned to attenuate expression of LINC00261 and FOXO1" -target gene hsa-mir-21a Obesity 30020817 Long Noncoding RNA GAS5 Suppresses 3T3-L1 Cells Adipogenesis Through miR-21a-5p/PTEN Signal Pathway. -target gene hsa-mir-298 "Stroke, Ischemic" 30021197 MiR-298 Exacerbates Ischemia/Reperfusion Injury Following Ischemic Stroke by Targeting Act1. -target gene hsa-mir-129 "Carcinoma, Thyroid, Papillary" 30021343 MiR-129 regulates growth and invasion by targeting MAL2 in papillary thyroid carcinoma. -target gene hsa-mir-149 "Carcinoma, Cervical" 30021347 miR-149 regulates the proliferation and apoptosis of cervical cancer cells by targeting GIT1. -target gene hsa-mir-19a "Carcinoma, Hepatocellular" 30021351 microRNA-19a-3p promotes tumor metastasis and chemoresistance through the PTEN/Akt pathway in hepatocellular carcinoma. -target gene hsa-mir-15a "Carcinoma, Cervical" 30021370 Over-expression of miR-15a-3p enhances the radiosensitivity of cervical cancer by targeting tumor protein D52. -target gene hsa-mir-519d Colorectal Carcinoma 30021381 MicroRNA-519d-3p inhibits cell proliferation and migration by targeting TROAP in colorectal cancer. -target gene hsa-mir-373 "Carcinoma, Pancreatic" 30021382 MiR-373-3p enhances the chemosensitivity of gemcitabine through cell cycle pathway by targeting CCND2 in pancreatic carcinoma cells. -target gene hsa-mir-363 Colorectal Carcinoma 30021386 MiR-363-3p suppresses tumor growth and metastasis of c via targeting SphK2. -target gene hsa-mir-26a Lung Injury [unspecific] 30024304 MicroRNA dysregulation in lung injury: the role of the miR-26a/EphA2 axis in regulation of endothelial permeability. -target gene hsa-mir-550a "Carcinoma, Lung, Non-Small-Cell" 30024604 MiR-550a-3p promotes non-small cell lung cancer cell proliferation and metastasis through down-regulating TIMP2. -target gene hsa-mir-132 Glioma 30024792 miR-132-3p boosts caveolae-mediated transcellular transport in glioma endothelial cells by targeting PTEN/PI3K/PKB/Src/Cav-1 signaling pathway. -target gene hsa-mir-16 Polycystic Ovarian Syndrome 30025387 MicroRNA-16 Promotes Ovarian Granulosa Cell Proliferation and Suppresses Apoptosis Through Targeting PDCD4 in Polycystic Ovarian Syndrome. -target gene hsa-mir-29b Cardiac Fibrosis 30025410 MicroRNA-29b Regulates the Mitochondria-Dependent Apoptotic Pathway by Targeting Bax in Doxorubicin Cardiotoxicity. -target gene hsa-mir-1296 Colorectal Carcinoma 30026827 "MicroRNA-1296 Facilitates Proliferation, Migration And Invasion Of Colorectal Cancer Cells By Targeting SFPQ." -target gene hsa-mir-616 Preeclampsia 30028057 MiR-616-3p modulates cell proliferation and migration through targeting tissue factor pathway inhibitor 2 in preeclampsia. -target gene hsa-mir-219a Sepsis 30028330 MicroRNA-219 alleviates glutamate-induced neurotoxicity in cultured hippocampal neurons by targeting calmodulin-dependent protein kinase II gamma. -target gene hsa-mir-5590 Gastric Neoplasms 30029874 miR-5590-3p inhibited tumor growth in gastric cancer by targeting DDX5/AKT/m-TOR pathway. -target gene hsa-mir-30d Lung Fibrosis 30029934 MicroRNA-30d/JAG1 axis modulates pulmonary fibrosis through Notch signaling pathway. -target gene hsa-mir-204 Gastric Neoplasms 30031110 oxaliplatin impairs sensory neurons arborization through up-regulation of miR-204 that decreases PlexinA2 expression and neurite length -target gene hsa-mir-181d Osteosarcoma 30031607 miR-181d-5p-FOXP1 feedback loop modulates the progression of osteosarcoma. -target gene hsa-mir-140 "Carcinoma, Breast" 30032164 miR-140-5p inhibits the proliferation and enhances the efficacy of doxorubicin to breast cancer stem cells by targeting Wnt1. -target gene hsa-mir-181a Glioma 30036882 "Kaiso (ZBTB33) Downregulation by Mirna-181a Inhibits Cell Proliferation, Invasion, and the Epithelial-Mesenchymal Transition in Glioma Cells." -target gene hsa-mir-135b Hypertrophy 30037628 Overexpression of miR-135b attenuates pathological cardiac hypertrophy by targeting CACNA1C. -target gene hsa-mir-384 Glioma 30038507 MicroRNA-384 inhibits proliferation migration and invasion of glioma by targeting at CDC42. -target gene hsa-mir-19b "Carcinoma, Breast" 30038508 miR-19b serves as a prognostic biomarker of breast cancer and promotes tumor progression through PI3K/AKT signaling pathway. -target gene hsa-mir-194 Hepatitis B Virus Infection 30044042 MicroRNA-194 protects against chronic hepatitis B-related liver damage by promoting hepatocyte growth via ACVR2B. -target gene hsa-mir-324 Hemophilus Influenzae Infection 30045983 MicroRNA hsa-miR-324-5p Suppresses H5N1 Virus Replication by Targeting the Viral PB1 and Host CUEDC2. -target gene hsa-mir-26a Rheumatoid Arthritis 30046030 miR-26a-5p Regulates Synovial Fibroblast Invasion in Patients with Rheumatoid Arthritis by Targeting Smad 1. -target gene hsa-mir-363 Ovarian Neoplasms 30046387 "miR-363 confers taxane resistance in ovarian cancer by targeting the Hippo pathway member, LATS2." -target gene hsa-mir-34a Osteoarthritis 30048987 "MiR-34a Enhances Chondrocyte Apoptosis, Senescence and Facilitates Development of Osteoarthritis by Targeting DLL1 and Regulating PI3K/AKT Pathway." -target gene hsa-mir-143 "Leukemia, Myeloid, Acute" 30050105 MicroRNA-143 targets ERK5 in granulopoiesis and predicts outcome of patients with acute myeloid leukemia. -target gene hsa-mir-29 "Diabetes Mellitus, Type 2" 30050458 "Among the enriched miRNAs was miR-29, a regulator of GLUT4 mRNA expression" -target gene hsa-mir-106 Hyperglycemia 30055307 MicroRNA-106 attenuates hyperglycemia-induced vascular endothelial cell dysfunction by targeting HMGB1. -target gene hsa-mir-1273g Colorectal Carcinoma 30056111 miR-1273g silences MAGEA3/6 to inhibit human colorectal cancer cell growth via activation of AMPK signaling. -target gene hsa-mir-384 Osteoarthritis 30057417 Inhibition of microRNA-384-5p alleviates osteoarthritis through its effects on inhibiting apoptosis of cartilage cells via the NF-¦ÊB signaling pathway by targeting SOX9. -target gene hsa-mir-28 Neuropathic Pain 30058089 miR-28-5p/Zeb1 axis can be a novel therapeutic target for neuropathic pain treatment -target gene hsa-mir-485 Lung Neoplasms 30058740 Epigallocatechin-3-gallate inhibited cancer stem cell-like properties by targeting hsa-mir-485-5p/RXR¦Á in lung cancer. -target gene hsa-mir-7 Neoplasms [unspecific] 30060955 it suggests that the level of NF90 is increased by a negative feedback loop between NF90 and miR-7 in tumor tissues under physiological conditions -target gene hsa-mir-455 "Carcinoma, Bladder" 30061227 dysfunction of the miR-455-TJP1 axis is involved in bladder cancer cell growth and metastasis -target gene hsa-mir-342 Nasopharyngeal Neoplasms 30061949 MicroRNA-342 inhibits cell proliferation and invasion in nasopharyngeal carcinoma by directly targeting ZEB1. -target gene hsa-mir-95 Osteoarthritis 30063117 Exosomal miR-95-5p regulates chondrogenesis and cartilage degradation via histone deacetylase 2/8. -target gene hsa-mir-145 "Carcinoma, Lung, Non-Small-Cell" 30065618 miR-145 and miR-497 suppress TGF-¦Â-induced epithelial-mesenchymal transition of non-small cell lung cancer by targeting MTDH. -target gene hsa-mir-497 "Carcinoma, Lung, Non-Small-Cell" 30065618 miR-145 and miR-497 suppress TGF-¦Â-induced epithelial-mesenchymal transition of non-small cell lung cancer by targeting MTDH. -target gene hsa-mir-26a "Carcinoma, Breast" 30066905 A miR-26a/E2F7 feedback loop contributes to tamoxifen resistance in ER-positive breast cancer. -target gene hsa-mir-22 Asthma 30068332 "Influenza A virus infection dysregulates the expression of microRNA-22 and its targets; CD147 and HDAC4, in epithelium of asthmatics." -target gene hsa-mir-1258 "Carcinoma, Lung, Non-Small-Cell" 30069987 MicroRNA-1258 suppresses tumour progression via GRB2/Ras/Erk pathway in non-small-cell lung cancer. -target gene hsa-mir-340 Colorectal Carcinoma 30070320 MiR-340-5p is a potential prognostic indicator of colorectal cancer and modulates ANXA3. -target gene hsa-mir-1269a Colorectal Carcinoma 30070324 MiR-1269a acts as an onco-miRNA in non-small cell lung cancer via down-regulating SOX6. -target gene hsa-mir-608 "Adenocarcinoma, Lung" 30070326 MiR-608 exerts tumor suppressive function in lung adenocarcinoma by directly targeting MIF. -target gene hsa-mir-122 Glioma 30070328 MiR-122 inhibits cell proliferation and induces apoptosis by targeting runt-related transcription factors 2 in human glioma. -target gene hsa-mir-135b Colorectal Carcinoma 30071508 Knockdown of Mir-135b Sensitizes Colorectal Cancer Cells to Oxaliplatin-Induced Apoptosis Through Increase of FOXO1. -target gene hsa-mir-543 Esophageal Neoplasms 30071514 "MiR-543 Promotes Migration, Invasion and Epithelial-Mesenchymal Transition of Esophageal Cancer Cells by Targeting Phospholipase A2 Group IVA." -target gene hsa-mir-34a Ovarian Neoplasms 30071534 c-Myc re-expression targeting by miR-34a inhibitors protected cells from apoptosis or reversed cisplatin resistance following HDAC1 knockdown or/and cisplatin exposure -target gene hsa-let-7a Chronic Obstructive Pulmonary Disease 30072506 "KRAS and EDN1 were identified as key regulators of CMH and were negatively correlated predicted targets of miR-134-5p and let-7a-5p, let-7d-5p, and let-7f-5p" -target gene hsa-let-7d Chronic Obstructive Pulmonary Disease 30072506 "KRAS and EDN1 were identified as key regulators of CMH and were negatively correlated predicted targets of miR-134-5p and let-7a-5p, let-7d-5p, and let-7f-5p" -target gene hsa-let-7f Chronic Obstructive Pulmonary Disease 30072506 "KRAS and EDN1 were identified as key regulators of CMH and were negatively correlated predicted targets of miR-134-5p and let-7a-5p, let-7d-5p, and let-7f-5p" -target gene hsa-mir-134 Chronic Obstructive Pulmonary Disease 30072506 "KRAS and EDN1 were identified as key regulators of CMH and were negatively correlated predicted targets of miR-134-5p and let-7a-5p, let-7d-5p, and let-7f-5p" -target gene hsa-mir-31 Hypertrophy 30074205 Atorvastatin Attenuates Myocardial Hypertrophy Induced by Chronic Intermittent Hypoxia In Vitro Partly through miR-31/PKC¦Å Pathway. -target gene hsa-mir-31a Hypertrophic Scar 30075370 Inhibition of miR-31a-5p decreases inflammation by down-regulating IL-25 expression in human dermal fibroblast cells (CC-2511 cells) under hyperthermic stress via Wnt/¦Â-catenin pathway. -target gene hsa-mir-29c Allergic Asthma 30075787 The role of miR-29c/B7-H3 axis in children with allergic asthma -target gene hsa-mir-638 Asthma 30076719 MicroRNA-638 inhibits human airway smooth muscle cell proliferation and migration through targeting cyclin D1 and NOR1. -target gene hsa-mir-125a "Carcinoma, Breast" 30076753 MiR-125a-5p functions as a tumour suppressor in breast cancer by downregulating BAP1. -target gene hsa-mir-590 "Carcinoma, Breast" 30076901 miR-590-3p inhibits proliferation and promotes apoptosis by targeting activating transcription factor 3 in human breast cancer cells. -target gene hsa-mir-224 "Carcinoma, Pancreatic" 30078003 MicroRNA-224 Promotes Pancreatic Cancer Cell Proliferation and Migration by Targeting the TXNIP-Mediated HIF1¦Á Pathway. -target gene hsa-mir-27b Kawasaki Syndrome 30078021 miR-27b Suppresses Endothelial Cell Proliferation and Migration by Targeting Smad7 in Kawasaki Disease. -target gene hsa-mir-141 Hyperglycemia 30078183 miR-141-3p targets not only protein-coding genes but also the lncRNA H19 -target gene hsa-mir-181a Vascular Disease [unspecific] 30080293 FMRP regulates endothelial cell proliferation and angiogenesis via the miR-181a-CaM-CaMKII pathway. -target gene hsa-mir-506 Retinoblastoma 30080301 "MiR-506-3p inhibits cell proliferation, induces cell cycle arrest and apoptosis in retinoblastoma by directly targeting NEK6." -target gene hsa-mir-29b Asthma 30081328 miR-29b directly targets activation-induced cytidine deaminase in human B cells and can limit its inappropriate expression in na?ve B cells. -target gene hsa-mir-301b Melanoma 30081934 Isoliquiritigenin suppresses human melanoma growth by targeting miR-301b/LRIG1 signaling. -target gene hsa-mir-125b "Carcinoma, Lung" 30082521 MiR-125b-1-3p Exerts Antitumor Functions in Lung Carcinoma Cells by Targeting S1PR1. -target gene hsa-mir-375 "Carcinoma, Renal Cell, Clear-Cell" 30082525 MicroRNA-375 Suppresses the Tumor Aggressive Phenotypes of Clear Cell Renal Cell Carcinomas through Regulating YWHAZ. -target gene hsa-mir-218 Parkinson Disease 30083784 "Our results reveal that SLC6A3, TH, and EBF3 targeted by miR-218 could be involved in PD" -target gene hsa-mir-191 "Carcinoma, Breast" 30084985 Amplification of Hsa-miR-191/425 Locus Promotes Breast Cancer Proliferation and Metastasis by Targeting DICER1. -target gene hsa-mir-425 "Carcinoma, Breast" 30084985 Amplification of Hsa-miR-191/425 Locus Promotes Breast Cancer Proliferation and Metastasis by Targeting DICER1. -target gene hsa-mir-133a "Carcinoma, Hepatocellular" 30086463 MiR-133a acts as an anti-oncogene in Hepatocellular carcinoma by inhibiting FOSL2 through TGF-¦Â/Smad3 signaling pathway. -target gene hsa-mir-485 Colorectal Carcinoma 30087700 microRNA-485-5p Functions as a Tumor Suppressor in Colorectal Cancer Cells by Targeting CD147. -target gene hsa-mir-302c "Carcinoma, Hepatocellular" 30087710 The tumor suppressive miR-302c-3p inhibits migration and invasion of hepatocellular carcinoma cells by targeting TRAF4. -target gene hsa-mir-323a Osteosarcoma 30088225 MiR-323a-3p suppressed the glycolysis of osteosarcoma via targeting LDHA. -target gene hsa-mir-21 Neoplasms [unspecific] 30092298 MiR-21 regulates the ACAT1 gene in MCF-7 cells. -target gene hsa-mir-613 "Carcinoma, Breast, Triple Negative" 30092563 miR-613 directly bound to the 3'-untranslated region (3'-UTR) of WBP2 and regulated the expression of WBP2 -target gene hsa-mir-142 "Carcinoma, Hepatocellular" 30092578 lncRNA TUG1-Mediated Mir-142-3p Downregulation Contributes to Metastasis and the Epithelial-to-Mesenchymal Transition of Hepatocellular Carcinoma by Targeting ZEB1. -target gene hsa-mir-1292 "Carcinoma, Gastric" 30094096 "MicroRNA-1292-5p inhibits cell growth, migration and invasion of gastric carcinoma by targeting DEK." -target gene hsa-mir-942 Liver Fibrosis 30097701 MicroRNA-942 mediates hepatic stellate cell activation by regulating BAMBI expression in human liver fibrosis. -target gene hsa-mir-499 Obesity 30097922 MiR-499/PRDM16 axis modulates the adipogenic differentiation of mouse skeletal muscle satellite cells. -target gene hsa-mir-143 Melanoma 30098313 MicroRNA-143-3p inhibits growth and invasiveness of melanoma cells by targeting cyclooxygenase-2 and inversely correlates with malignant melanoma progression. -target gene hsa-mir-93 "Carcinoma, Cervical" 30098344 Clinical significance and functions of microRNA-93/CDKN1A axis in human cervical cancer. -target gene hsa-mir-101 "Carcinoma, Hepatocellular" 30098428 LINC00052/miR-101-3p axis inhibits cell proliferation and metastasis by targeting SOX9 in hepatocellular carcinoma. -target gene hsa-mir-101 Glioma 30098431 Long noncoding RNA SNHG12 facilitates the tumorigenesis of glioma through miR-101-3p/FOXP1 axis. -target gene hsa-mir-217 "Carcinoma, Bladder" 30098434 Downregulation of circular RNA hsa_circ_0000144 inhibits bladder cancer progression via stimulating miR-217 and suppressing RUNX2 expression. -target gene hsa-mir-132 Schizophrenia 30099093 "Moreover, the polycomb-associated H3K27 methyltransferase, EZH1, is regulated by miR-132 and upregulated in the PFC of schizophrenics" -target gene hsa-mir-148b Kidney Neoplasms 30099339 MiR-148b-3p inhibits renal carcinoma cell growth and pro-angiogenic phenotype of endothelial cell potentially by modulating FGF2. -target gene hsa-mir-758 Glioblastoma 30099442 "Mir-758-5p Suppresses Glioblastoma Proliferation, Migration and Invasion by Targeting ZBTB20." -target gene hsa-mir-33a Laryngeal Neoplasms 30102806 Antiproliferative potential of miR-33a in laryngeal cancer Hep-2 cells via targeting PIM1. -target gene hsa-mir-34a Lung Neoplasms 30102929 miR-34a negatively regulates the expression of BCL2 and c-MET (genes associated with survival of tumor cells) -target gene hsa-mir-23c "Carcinoma, Hepatocellular" 30103114 miR-23c suppresses tumor growth of human hepatocellular carcinoma by attenuating ERBB2IP. -target gene hsa-mir-520b Lung Neoplasms 30106218 MiR-520b restrains cell growth by targeting HDAC4 in lung cancer. -target gene hsa-mir-498 "Leukemia, Myeloid, Acute" 30107988 Evaluation of the effect of TIM-3 suppression by miR-498 and its effect on apoptosis and proliferation rate of HL-60 cell line. -target gene hsa-mir-96 "Carcinoma, Cervical" 30108433 MiR-96 enhances cellular proliferation and tumorigenicity of human cervical carcinoma cells through PTPN9. -target gene hsa-mir-1297 "Squamous Cell Carcinoma, Oral" 30108442 microRNA-1297 involves in the progression of oral squamous cell carcinoma through PTEN. -target gene hsa-mir-30b Glioma 30108445 MiR-30b-5p modulates glioma cell proliferation by direct targeting MTDH. -target gene hsa-mir-582 "Carcinoma, Endometrial" 30108448 Upregulation of miR-582-5p regulates cell proliferation and apoptosis by targeting AKT3 in human endometrial carcinoma. -target gene hsa-mir-4728 "Lymphoma, Burkitt" 30108451 MicroRNA-4728 serves as a suppressor and antagonist of oncogenic MAPK in Burkitt lymphoma. -target gene hsa-mir-4728 "Carcinoma, Thyroid, Papillary" 30108452 MicroRNA-4728 mediated regulation of MAPK oncogenic signaling in papillary thyroid carcinoma. -target gene hsa-mir-204 Kidney Diseases [unspecific] 30110560 MicroRNA-204-5p suppresses IL6-mediated inflammatory response and chemokine generation in HK-2 renal tubular epithelial cells by targeting IL6R. -target gene hsa-mir-206 Soft Tissue Sarcoma 30111166 The oncomir face of microRNA-206: A permanent miR-206 transfection study. -target gene hsa-mir-34a "Leukemia, Lymphocytic, Chronic, B-Cell" 30111844 MicroRNA miR-34a downregulates FOXP1 during DNA damage response to limit BCR signalling in chronic lymphocytic leukaemia B cells. -target gene hsa-mir-153 Gastric Neoplasms 30112020 MicroRNA-153 functions as a tumor suppressor in gastric cancer via targeting Kruppel-like factor 5. -target gene hsa-mir-340 Acute Ischemic Stroke 30112629 "Acute stroke induces the downregulation of miR-340-5p, which subsequently upregulates ARG1 protein expression" -target gene hsa-mir-369 "Carcinoma, Thyroid, Papillary" 30114378 Downregulation of TSPAN13 by miR-369-3p inhibits cell proliferation in papillary thyroid cancer (PTC). -target gene hsa-mir-6852 Colorectal Carcinoma 30116340 miR-6852 serves as a prognostic biomarker in colorectal cancer and inhibits tumor growth and metastasis by targeting TCF7. -target gene hsa-mir-379 Nasopharyngeal Neoplasms 30116374 "MicroRNA-379 suppresses cell proliferation, migration and invasion in nasopharyngeal carcinoma by targeting tumor protein D52." -target gene hsa-mir-26a Neuropathic Pain 30118880 Effects of miR-26a-5p on neuropathic pain development by targeting MAPK6 in in CCI rat models. -target gene hsa-mir-539 "Carcinoma, Lung, Non-Small-Cell" 30119173 miR-539 enhances chemosensitivity to cisplatin in non-small cell lung cancer by targeting DCLK1. -target gene hsa-mir-30c Atherosclerosis 30119891 MicroRNA-30c-5p inhibits NLRP3 inflammasome-mediated endothelial cell pyroptosis through FOXO3 down-regulation in atherosclerosis. -target gene hsa-mir-30a Hidradenitis Suppurativa 30120935 Nicastrin/miR-30a-3p/RAB31 Axis Regulates Keratinocyte Differentiation by Impairing EGFR Signaling in Familial Acne Inversa. -target gene hsa-mir-494 Acute Respiratory Distress Syndrome 30121199 MicroRNA-494 inhibition alleviates acute lung injury through Nrf2 signaling pathway via NQO1 in sepsis-associated acute respiratory distress syndrome. -target gene hsa-mir-122 "Carcinoma, Biliary Tract" 30121648 "miR-122-5p Inhibits the Proliferation, Invasion and Growth of Bile Duct Carcinoma Cells by Targeting ALDOA." -target gene hsa-mir-486 Myocardial Infarction 30121658 MicroRNA-486 Alleviates Hypoxia-Induced Damage in H9c2 Cells by Targeting NDRG2 to Inactivate JNK/C-Jun and NF-¦ÊB Signaling Pathways. -target gene hsa-mir-223 "Lymphoma, Mantle-Cell" 30122018 "The expression of miR-223 was repressed in MCL and was associated with poor clinical outcomes, which may be probably attributed to its direct targeting SOX11" -target gene hsa-mir-140 Rheumatoid Arthritis 30123050 "the novel miR-140-3p-FGF9 interaction was validated in different microRNA prediction databases, and proposed to participate in the pathogenesis of joint destruction through dysregulated cell growth in RA" -target gene hsa-mir-524 Osteosarcoma 30123092 MicroRNA-524 promotes cell proliferation by down-regulating PTEN expression in osteosarcoma. -target gene hsa-mir-151a Visceral Leishmaniasis 30125570 "we identified target gene of differentially expressed miRNAs (target miRNAs: hsa-mir-15b, hsa-mir-671, hsa-mir-151a and has-mir-30c) which was confirmed by real time stem-loop PCR" -target gene hsa-mir-15b Visceral Leishmaniasis 30125570 "we identified target gene of differentially expressed miRNAs (target miRNAs: hsa-mir-15b, hsa-mir-671, hsa-mir-151a and has-mir-30c) which was confirmed by real time stem-loop PCR" -target gene hsa-mir-30c Visceral Leishmaniasis 30125570 "we identified target gene of differentially expressed miRNAs (target miRNAs: hsa-mir-15b, hsa-mir-671, hsa-mir-151a and has-mir-30c) which was confirmed by real time stem-loop PCR" -target gene hsa-mir-671 Visceral Leishmaniasis 30125570 "we identified target gene of differentially expressed miRNAs (target miRNAs: hsa-mir-15b, hsa-mir-671, hsa-mir-151a and has-mir-30c) which was confirmed by real time stem-loop PCR" -target gene hsa-mir-150 "Carcinoma, Thyroid, Papillary" 30126001 "MicroRNA-150-5p affects cell proliferation, apoptosis, and EMT by regulation of the BRAFV600E mutation in papillary thyroid cancer cells." -target gene hsa-mir-181a "Carcinoma, Breast" 30126376 "Several miRNAs including miR-18a, miR-19a and miR-181a were predicted in silico to target the canine estrogen receptor (ESR1¦Á)" -target gene hsa-mir-18a "Carcinoma, Breast" 30126376 "Several miRNAs including miR-18a, miR-19a and miR-181a were predicted in silico to target the canine estrogen receptor (ESR1¦Á)" -target gene hsa-mir-19a "Carcinoma, Breast" 30126376 "Several miRNAs including miR-18a, miR-19a and miR-181a were predicted in silico to target the canine estrogen receptor (ESR1¦Á)" -target gene hsa-mir-16 Gastric Neoplasms 30127890 miR-16 targets SALL4 to repress the proliferation and migration of gastric cancer. -target gene hsa-mir-106b "Carcinoma, Hepatocellular" 30127897 miR-106b targets DAB2 to promote hepatocellular carcinoma cell proliferation and metastasis. -target gene hsa-mir-18a Osteosarcoma 30127908 miR-18a-5p promotes cell invasion and migration of osteosarcoma by directly targeting IRF2. -target gene hsa-mir-375 Liver Neoplasms 30127930 Upregulation of miR-375 inhibits human liver cancer cell growth by modulating cell proliferation and apoptosis via targeting ErbB2. -target gene hsa-mir-2682 Osteosarcoma 30127935 "MicroRNA-2682-3p inhibits osteosarcoma cell proliferation by targeting CCND2, MMP8 and Myd88." -target gene hsa-mir-761 Gastric Neoplasms 30127949 microRNA-761 regulates glycogen synthase kinase 3¦Â expression and promotes the proliferation and cell cycle of human gastric cancer cells. -target gene hsa-mir-449b "Carcinoma, Lung, Non-Small-Cell" 30128865 Inhibitory Effect of MiR-449b on Cancer Cell Growth and Invasion through LGR4 in Non-Small-Cell Lung Carcinoma. -target gene hsa-mir-224 "Carcinoma, Cervical" 30129088 MicroRNA-224 inhibition prevents progression of cervical carcinoma by targeting PTX3. -target gene hsa-mir-5582 Neoplasms [unspecific] 30129155 "Hsa-miR-5582-3P regulatory effect on TGF¦Â signaling through targeting of TGF¦Â-R1, TGF¦Â-R2, SMAD3, and SMAD4 transcripts." -target gene hsa-mir-766 "Carcinoma, Hepatocellular" 30130435 MicroRNA-766 promotes cancer progression by targeting NR3C2 in hepatocellular carcinoma. -target gene hsa-mir-124a Glioma 30131250 "microRNA-124a suppresses PHF19 over-expression, EZH2 hyper-activation, and aberrant cell proliferation in human glioma." -target gene hsa-mir-211 Glaucoma 30131252 Intraocular miR-211 exacerbates pressure-induced cell death in retinal ganglion cells via direct repression of FRS2 signaling. -target gene hsa-mir-1254 "Carcinoma, Breast" 30132526 MicroRNA-1254 exerts?oncogenic effects by directly targeting RASSF9 in human breast cancer. -target gene hsa-mir-424 Hemangioma 30132564 MicroRNA?424 suppresses the proliferation of hemangioma?derived endothelial cells by targeting VEGFR?2. -target gene hsa-mir-6089 Rheumatoid Arthritis 30132861 Exosome-encapsulated miR-6089 regulates inflammatory response via targeting TLR4. -target gene hsa-mir-26a Ischemia-Reperfusion Injury 30132885 Effect of microRNA-26a on vascular endothelial cell injury caused by lower extremity ischemia-reperfusion injury through the AMPK pathway by targeting PFKFB3. -target gene hsa-mir-30e Ovarian Neoplasms 30134224 the expression of YWHAZ was directly down-regulated by miR-30e in resistant ovarian cancer cells -target gene hsa-mir-96 Chronic Cerebral Hypoperfusion 30134226 miR-96 may play a key role in autophagy under CCH by regulating mTOR -target gene hsa-mir-16 "Squamous Cell Carcinoma, Oral" 30136280 MicroRNA-16 functions as a tumor-suppressor gene in oral squamous cell carcinoma by targeting AKT3 and BCL2L2. -target gene hsa-mir-381 "Carcinoma, Bladder" 30138038 Dual regulatory role of CCNA2 in modulating CDK6 and MET-mediated cell-cycle pathway and EMT progression is blocked by miR-381-3p in bladder cancer. -target gene hsa-mir-154 "Carcinoma, Renal Cell" 30138594 Oncogene miR-154-5p regulates cellular function and acts as a molecular marker with poor prognosis in renal cell carcinoma. -target gene hsa-mir-27a Ovarian Neoplasms 30138596 Integrated microarray meta-analysis identifies miRNA-27a as an oncogene in ovarian cancer by inhibiting FOXO1. -target gene hsa-mir-135a Ovarian Neoplasms 30138893 MicroRNA-135a-3p is downregulated and serves as a tumour suppressor in ovarian cancer by targeting CCR2. -target gene hsa-mir-454 Preeclampsia 30138897 "MicroRNA-454 is involved in regulating trophoblast cell proliferation, apoptosis, and invasion in preeclampsia by modulating the expression of ephrin receptor B4." -target gene hsa-mir-504 "Carcinoma, Hepatocellular" 30142536 MicroRNA-504 functions as a tumor suppressor in hepatocellular carcinoma through inhibiting Frizzled-7-mediated-Wnt/¦Â-catenin signaling. -target gene hsa-mir-1258 Colorectal Carcinoma 30144184 Upregulated miR-1258 regulates cell cycle and inhibits cell proliferation by directly targeting E2F8 in CRC. -target gene hsa-mir-202 Colorectal Carcinoma 30144500 MicroRNA-202-5p functions as a tumor suppressor in colorectal carcinoma by directly targeting SMARCC1. -target gene hsa-mir-383 Cholangiocarcinoma 30145803 "miR-383 promotes cholangiocarcinoma cell proliferation, migration, and invasion through targeting IRF1." -target gene hsa-mir-27a Ischemia-Reperfusion Injury 30145824 MiR-27a-5p regulates apoptosis of liver ischemia-reperfusion injury in mice by targeting Bach1. -target gene hsa-mir-766 "Carcinoma, Hepatocellular" 30145863 MicroRNA-766-3p Inhibits Tumour Progression by Targeting Wnt3a in Hepatocellular Carcinoma. -target gene hsa-mir-495 "Carcinoma, Lung, Non-Small-Cell" 30146342 The miR 495-UBE2C-ABCG2/ERCC1 axis reverses cisplatin resistance by downregulating drug resistance genes in cisplatin-resistant non-small cell lung cancer cells. -target gene hsa-mir-133a Asthma 30146725 MicroRNA-133a alleviates airway remodeling in asthtama through PI3K/AKT/mTOR signaling pathway by targeting IGF1R. -target gene hsa-mir-126 Acute Kidney Failure 30146769 "Gain-and-loss-of-function studies demonstrated that miRNAs, such as miR-24, miR-126, miR-494, and miR-687, may bind to the 3'-untranslated region of their target genes to regulate inflammation, programmed cell death, and cell cycle in the injury and repair stages of AKI" -target gene hsa-mir-24 Acute Kidney Failure 30146769 "Gain-and-loss-of-function studies demonstrated that miRNAs, such as miR-24, miR-126, miR-494, and miR-687, may bind to the 3'-untranslated region of their target genes to regulate inflammation, programmed cell death, and cell cycle in the injury and repair stages of AKI" -target gene hsa-mir-494 Acute Kidney Failure 30146769 "Gain-and-loss-of-function studies demonstrated that miRNAs, such as miR-24, miR-126, miR-494, and miR-687, may bind to the 3'-untranslated region of their target genes to regulate inflammation, programmed cell death, and cell cycle in the injury and repair stages of AKI" -target gene hsa-mir-687 Acute Kidney Failure 30146769 "Gain-and-loss-of-function studies demonstrated that miRNAs, such as miR-24, miR-126, miR-494, and miR-687, may bind to the 3'-untranslated region of their target genes to regulate inflammation, programmed cell death, and cell cycle in the injury and repair stages of AKI" -target gene hsa-mir-181c Machado-Joseph Disease 30147021 MiR-32 and miR-181c effectively targeted the 3¡¯UTR of ATXN3 and suppressed the expression of ATXN3 -target gene hsa-mir-32 Machado-Joseph Disease 30147021 MiR-32 and miR-181c effectively targeted the 3¡¯UTR of ATXN3 and suppressed the expression of ATXN3 -target gene hsa-mir-495 Gastric Neoplasms 30147110 MicroRNA-495 Confers Increased Sensitivity to Chemotherapeutic Agents in Gastric Cancer via the Mammalian Target of Rapamycin (mTOR) Signaling Pathway by Interacting with Human Epidermal Growth Factor Receptor 2 (ERBB2). -target gene hsa-mir-7641 "Carcinoma, Bladder" 30149755 Curcumin Suppresses microRNA-7641-Mediated Regulation of p16 Expression in Bladder Cancer. -target gene hsa-mir-451 Osteoporosis 30151091 MicroRNA-451 blockade promotes osteoblastic differentiation and skeletal anabolic effects by promoting YWHAZ-mediated RUNX2 protein stabilization. -target gene hsa-mir-27a Peri-Implantitis 30151888 MiR-27a targets DKK2 and SFRP1 to promote reosseointegration in the regenerative treatment of peri-implantitis. -target gene hsa-mir-29 "Carcinoma, Renal Cell" 30153702 Genes regulated by the anti-tumor miR-29 family are closely involved in the molecular pathogenesis of renal cell carcinoma -target gene hsa-mir-590 Asthma 30154893 MicroRNA-590-5p represses proliferation of human fetal airway smooth muscle cells by targeting signal transducer and activator of transcription 3. -target gene hsa-mir-362 Lung Neoplasms 30155491 Aberrant Expression of miR-362 Promotes Lung Cancer Metastasis through Downregulation of Sema3A. -target gene hsa-mir-145 "Carcinoma, Breast" 30157476 The Dysregulated Expression of KCNQ1OT1 and Its Interaction with Downstream Factors miR-145/CCNE2 in Breast Cancer Cells. -target gene hsa-mir-138 Sepsis 30157481 MicroRNA-138 Aggravates Inflammatory Responses of Macrophages by Targeting SIRT1 and Regulating the NF-¦ÊB and AKT Pathways. -target gene hsa-mir-381 "Carcinoma, Cervical" 30161290 miR-381-3p restrains cervical cancer progression by downregulating FGF7. -target gene hsa-mir-34a Gastric Neoplasms 30165351 Increased Lactate in Gastric Cancer Tumor-Infiltrating Lymphocytes Is Related to Impaired T Cell Function Due to miR-34a Deregulated Lactate Dehydrogenase A. -target gene hsa-mir-718 "Carcinoma, Thyroid, Papillary" 30166214 miR-718 is involved in malignancy of papillary thyroid cancer through repression of PDPK1. -target gene hsa-mir-889 Neoplasms [unspecific] 30167605 "Circ008913, via miR-889 regulation of DAB2IP/ZEB1, is involved in the arsenite-induced acquisition of CSC-like properties by human keratinocytes in carcinogenesis." -target gene hsa-mir-299 "Carcinoma, Hepatocellular" 30170358 MiR-299-3p functions as a tumor suppressor via targeting Sirtuin 5 in hepatocellular carcinoma. -target gene hsa-mir-126 Kaposi Sarcoma 30170375 MicroRNA-126 regulates the phosphatidylinositol-3 kinase (PI3K)/protein kinase B (AKT) pathway in SLK cells in vitro and the expression of its pathway members in Kaposi's sarcoma tissue. -target gene hsa-mir-139 Glioma 30170559 Targeting the Notch1 oncogene by miR-139-5p inhibits glioma metastasis and epithelial-mesenchymal transition (EMT). -target gene hsa-mir-483 "Carcinoma, Thyroid, Anaplastic" 30171257 "MicroRNA 483-3p targets Pard3 to potentiate TGF-¦Â1-induced cell migration, invasion, and epithelial-mesenchymal transition in anaplastic thyroid cancer cells." -target gene hsa-mir-874 Diabetic Nephropathy 30171701 MiR-874 alleviates renal injury and inflammatory response in diabetic nephropathy through targeting toll-like receptor-4. -target gene hsa-mir-200c Colorectal Carcinoma 30171714 Anticancer effects of miR-200c in colorectal cancer through BMI1. -target gene hsa-mir-200a Kidney Neoplasms 30171729 Decreased miR-200a-3p is a key regulator of renal carcinoma growth and migration by directly targeting CBL. -target gene hsa-mir-497 Glioma 30171955 miR-497/Wnt3a/c-jun feedback loop regulates growth and epithelial-to-mesenchymal transition phenotype in glioma cells. -target gene hsa-mir-1301 Osteosarcoma 30172867 MicroRNA-1301 inhibits migration and invasion of osteosarcoma cells by targeting BCL9. -target gene hsa-mir-29a Spinal Cord Injuries 30173324 Lentivirus-Mediated Overexpression of miR-29a Promotes Axonal Regeneration and Functional Recovery in Experimental Spinal Cord Injury via PI3K/Akt/mTOR Pathway. -target gene hsa-mir-483 Colon Neoplasms 30173777 Mir-483 inhibits colon cancer cell proliferation and migration by targeting TRAF1. -target gene hsa-mir-205 "Diabetes Mellitus, Type 2" 30174230 "miR-205-5p gain-of-function increases AKT phosphorylation and decreases SHIP2 in primary hepatocytes, resulting in FOXO inhibition" -target gene hsa-mir-543 Gastric Neoplasms 30174445 miRNA-543 promotes cell migration and invasion by targeting SPOP in gastric cancer. -target gene hsa-mir-1228 Lung Neoplasms 30176158 CircRNA hsa_circ_100395 regulates miR-1228/TCF21 pathway to inhibit lung cancer progression. -target gene hsa-mir-575 "Carcinoma, Hepatocellular" 30176933 Long noncoding RNA MIR31HG inhibits hepatocellular carcinoma proliferation and metastasis by sponging microRNA-575 to modulate ST7L expression. -target gene hsa-mir-125b "Carcinoma, Breast" 30177391 "miR-125b-5p inhibits breast cancer cell proliferation, migration and invasion by targeting KIAA1522." -target gene hsa-mir-214 Osteosarcoma 30178836 MicroRNA-214 functions as an oncogene in human osteosarcoma by targeting TRAF3. -target gene hsa-mir-192 Hepatitis B Virus Infection 30180281 Hepatitis B Virus Induces Autophagy to Promote its Replication by the Axis of miR-192-3p-XIAP via NF-¦ÊB Signaling. -target gene hsa-mir-451 Glioma 30180756 MiRNA-451 Inhibits Glioma Cell Proliferation and Invasion Through the mTOR/HIF-1¦Á/VEGF Signaling Pathway by Targeting CAB39. -target gene hsa-mir-214 Acute Kidney Failure 30180910 miR-214 ameliorates acute kidney injury via targeting DKK3 and activating of Wnt/¦Â-catenin signaling pathway. -target gene hsa-mir-1228 Osteosarcoma 30180920 Exosomal miR-1228 from cancer-associated fibroblasts promotes cell migration and invasion of osteosarcoma by directly targeting SCAI. -target gene hsa-mir-1179 "Carcinoma, Lung, Non-Small-Cell" 30180955 MicroRNA-1179 suppresses cell growth and invasion by targeting sperm-associated antigen 5-mediated Akt signaling in human non-small cell lung cancer. -target gene hsa-mir-876 "Squamous Cell Carcinoma, Head and Neck" 30181714 MiR-876-5p modulates head and neck squamous cell carcinoma metastasis and invasion by targeting vimentin. -target gene hsa-mir-320 Ischemia-Reperfusion Injury 30181740 MiR-320 regulates cardiomyocyte apoptosis induced by ischemia-reperfusion injury by targeting AKIP1. -target gene hsa-mir-21 "Lymphoma, Hodgkin" 30184526 MiR-21-5p is upregulated in cHL compared to GC-B cells and protects cHL cells from apoptosis possibly via targeting BTG2 and PELI1 -target gene hsa-mir-146a "Carcinoma, Renal Cell, Clear-Cell" 30184528 "Hypoxia-Regulated miR-146a Targets Cell Adhesion Molecule 2 to Promote Proliferation, Migration, and Invasion of Clear Cell Renal Cell Carcinoma." -target gene hsa-mir-137 Hypertrophic Scar 30184530 miR-137 Inhibits Proliferation and Metastasis of Hypertrophic Scar Fibroblasts via Targeting Pleiotrophin. -target gene hsa-mir-338 Rheumatoid Arthritis 30184542 "miR-338-5p Regulates the Viability, Proliferation, Apoptosis and Migration of Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Targeting NFAT5." -target gene hsa-mir-1 Prostate Neoplasms 30185212 The putative tumour suppressor miR-1-3p modulates prostate cancer cell aggressiveness by repressing E2F5 and PFTK1. -target gene hsa-mir-301a Neoplasms [unspecific] 30185897 Malignant Transformation of Human Bronchial Epithelial Cells Induced by Arsenic through STAT3/miR-301a/SMAD4 Loop. -target gene hsa-mir-21 Colorectal Carcinoma 30186399 Gambogic acid regulates the migration and invasion of colorectal cancer via microRNA-21-mediated activation of phosphatase and tensin homolog. -target gene hsa-mir-192 "Diabetes Mellitus, Type 1" 30186503 "miR-192 is upregulated in T1DM, regulates pancreatic ¦Â-cell development and inhibits insulin secretion through suppressing GLP-1 expression." -target gene hsa-mir-134 Neuropathic Pain 30187947 MiR-134-5p attenuates neuropathic pain progression through targeting Twist1. -target gene hsa-mir-210 "Carcinoma, Breast" 30188754 "Up-regulation of miR-210 induced by a hypoxic microenvironment promotes breast cancer stem cells metastasis, proliferation, and self-renewal by targeting E-cadherin." -target gene hsa-mir-23b Wound Healing 30188966 miR-23b promotes cutaneous wound healing through inhibition of the inflammatory responses by targeting ASK1. -target gene hsa-mir-590 Intracerebral Hemorrhage 30190124 MiR-590-5p alleviates intracerebral hemorrhage-induced brain injury through targeting Peli1 gene expression. -target gene hsa-mir-384 Diabetic Retinopathy 30191948 MicroRNA-384-3p inhibits retinal neovascularization through targeting hexokinase 2 in mice with diabetic retinopathy. -target gene hsa-mir-125b Ischemia-Reperfusion Injury 30193876 MicroRNA-125b mimic inhibits ischemia reperfusion-induced neuroinflammation and aberrant p53 apoptotic signalling activation through targeting TP53INP1. -target gene hsa-mir-324 Osteoarthritis 30193893 miR-324-5p is up regulated in end-stage osteoarthritis and regulates Indian Hedgehog signalling by differing mechanisms in human and mouse. -target gene hsa-mir-217 "Leukemia, Myeloid, Chronic" 30195077 miR-217 sensitizes chronic myelogenous leukemia cells to tyrosine kinase inhibitors by targeting pro-oncogenic anterior gradient 2. -target gene hsa-mir-98 Coronary Artery Disease 30195495 MicroRNA-98 regulates hepatic cholesterol metabolism via targeting sterol regulatory element-binding protein 2. -target gene hsa-mir-429 "Leukemia, Lymphoblastic, Acute, T-Cell" 30195757 A regulatory loop miR-429-MYCN-MFHAS1 was found potentially associated with the remission of T-ALL -target gene hsa-mir-663a Male Infertility 30195770 "miR-663a has been identified as the first microRNA that promotes the proliferation and DNA synthesis and suppresses the early apoptosis of human SSCs by targeting NFIX via cell cycle regulators Cyclin A2, Cyclin B1, and Cyclin E1" -target gene hsa-mir-327 Ischemia-Reperfusion Injury 30196287 Down-Regulation of miR-327 Alleviates Ischemia/Reperfusion-Induced Myocardial Damage by Targeting RP105. -target gene hsa-mir-423 Ischemia-Reperfusion Injury 30202848 "CFs participate in cardioprotective effects via an exosomes/microvesicles pathway during the acute phase of ischemia-reperfusion injury and Postcon can enhance this effect by upregulating the expression of CFs exosomes/microvesicles miR-423-3p, which targets the downstream effector RAP2C" -target gene hsa-mir-7 Lung Fibrosis 30202956 The CDR1as/miR-7/TGFBR2 axis modulates EMT in silica-induced pulmonary fibrosis. -target gene hsa-mir-182 "Squamous Cell Carcinoma, Oral" 30205384 miR-182-5p Promotes Growth in Oral Squamous Cell Carcinoma by Inhibiting CAMK2N1. -target gene hsa-mir-150 "Carcinoma, Hepatocellular" 30205391 "Long Non-Coding RNA PVT1/miR-150/ HIG2 Axis Regulates the Proliferation, Invasion and the Balance of Iron Metabolism of Hepatocellular Carcinoma." -target gene hsa-mir-214 "Carcinoma, Hepatocellular" 30206974 miR-214-5p targets KLF5 and suppresses proliferation of human hepatocellular carcinoma cells. -target gene hsa-mir-146b "Carcinoma, Renal Cell" 30206978 Inhibition of miR146b-5p suppresses CT-guided renal cell carcinoma by targeting TRAF6. -target gene hsa-mir-200c "Carcinoma, Breast" 30209363 Phosphodiesterase 7B/microRNA-200c relationship regulates triple-negative breast cancer cell growth. -target gene hsa-mir-451a "Carcinoma, Basal Cell" 30209892 miRNA-451a/TBX1 axis played a pivotal role in BCC tumorigenesis -target gene hsa-mir-298 Epilepsy 30210283 MicroRNA-298 Reverses Multidrug Resistance to Antiepileptic Drugs by Suppressing MDR1/P-gp Expression in vitro. -target gene hsa-mir-218 "Carcinoma, Cervical" 30210595 miRNA-218 regulates the proliferation and apoptosis of cervical cancer cells via targeting Gli3. -target gene hsa-mir-124 "Carcinoma, Hepatocellular" 30210622 Identification of microRNA-124 in regulation of Hepatocellular carcinoma through BIRC3 and the NF-¦ÊB pathway. -target gene hsa-mir-7702 Colorectal Carcinoma 30210694 Species-specific function of microRNA-7702 in human colorectal cancer cells via targeting TADA1. -target gene hsa-mir-506 "Carcinoma, Hepatocellular" 30210926 MicroRNA-506 suppresses invasiveness and metastasis of human hepatocellular carcinoma cells by targeting IL8. -target gene hsa-mir-21 Colon Neoplasms 30212824 "The CircRNA-ACAP2/Hsa-miR-21-5p/ Tiam1 Regulatory Feedback Circuit Affects the Proliferation, Migration, and Invasion of Colon Cancer SW480 Cells." -target gene hsa-mir-21 Renal Fibrosis 30212825 Total Flavonoids from Leaves of Carya Cathayensis Ameliorate Renal Fibrosis via the miR-21/Smad7 Signaling Pathway. -target gene hsa-mir-33b Osteosarcoma 30213286 MiR-33b inhibits osteosarcoma cell proliferation through suppression of glycolysis by targeting Lactate Dehydrogenase A (LDHA). -target gene hsa-mir-637 Melanoma 30213289 MiR-637 suppresses melanoma progression through directly targeting P-REX2a and inhibiting PTEN/AKT signaling pathway. -target gene hsa-mir-124 "Carcinoma, Bladder" 30214503 "MicroRNA-124 inhibits cell proliferation, invasion and migration by targeting CAV1 in bladder cancer." -target gene hsa-mir-6852 Gastric Neoplasms 30214548 MicroRNA-6852 suppresses cell proliferation and invasion via targeting forkhead box J1 in gastric cancer. -target gene hsa-mir-199a Ovarian Neoplasms 30214589 miRNA-199a-5p suppresses proliferation and invasion by directly targeting NF-¦ÊB1 in human ovarian cancer cells. -target gene hsa-mir-1265 Ovarian Neoplasms 30214617 Identifying miRNA-mRNA regulation network of major depressive disorder in ovarian cancer patients. -target gene hsa-mir-23b Ovarian Neoplasms 30214617 Identifying miRNA-mRNA regulation network of major depressive disorder in ovarian cancer patients. -target gene hsa-mir-33b Ovarian Neoplasms 30214617 Identifying miRNA-mRNA regulation network of major depressive disorder in ovarian cancer patients. -target gene hsa-mir-629 Ovarian Neoplasms 30214617 Identifying miRNA-mRNA regulation network of major depressive disorder in ovarian cancer patients. -target gene hsa-mir-933 Ovarian Neoplasms 30214617 Identifying miRNA-mRNA regulation network of major depressive disorder in ovarian cancer patients. -target gene hsa-mir-346 "Carcinoma, Hepatocellular" 30216442 LncRNA DGCR5 represses the development of hepatocellular carcinoma by targeting the miR-346/KLF14 axis. -target gene hsa-mir-409 "Carcinoma, Renal Cell, Clear-Cell" 30218446 Phosphoinositide-dependent kinase 1-associated glycolysis is regulated by miR-409-3p in clear cell renal cell carcinoma. -target gene hsa-mir-1306 "Carcinoma, Hepatocellular" 30219228 miR-1306-3p targets FBXL5 to promote metastasis of hepatocellular carcinoma through suppressing snail degradation. -target gene hsa-mir-34a Parkinson Disease 30221494 miR-34a/BCL-2 signaling axis contributes to apoptosis in MPP+ -induced SH-SY5Y cells. -target gene hsa-mir-501 Glioma 30221699 miR?501?3p sensitizes glioma cells to cisplatin by targeting MYCN. -target gene hsa-mir-184 Nasopharyngeal Neoplasms 30223264 "miR-184 Inhibits Tumor Invasion, Migration and Metastasis in Nasopharyngeal Carcinoma by Targeting Notch2." -target gene hsa-mir-146a Sepsis 30224945 miR-146a Attenuates Sepsis-Induced Myocardial Dysfunction by Suppressing IRAK1 and TRAF6 via Targeting ErbB4 Expression. -target gene hsa-mir-338 Glioma 30225541 MicroRNA-338-5p plays a tumor suppressor role in glioma through inhibition of the MAPK-signaling pathway by binding to FOXD1. -target gene hsa-mir-23a Atherosclerosis 30227118 MicroRNA-23a-5p promotes atherosclerotic plaque progression and vulnerability by repressing ATP-binding cassette transporter A1/G1 in macrophages. -target gene hsa-mir-4317 "Carcinoma, Lung, Non-Small-Cell" 30227870 miR-4317 suppresses non-small cell lung cancer (NSCLC) by targeting fibroblast growth factor 9 (FGF9) and cyclin D2 (CCND2). -target gene hsa-mir-204 "Carcinoma, Breast, Triple Negative" 30228364 Molecular pathogenesis of triple-negative breast cancer based on microRNA expression signatures: antitumor miR-204-5p targets AP1S3. -target gene hsa-mir-363 "Carcinoma, Renal Cell" 30229899 "MicroRNA-363 inhibits angiogenesis, proliferation, invasion, and migration of renal cell carcinoma via inactivation of the Janus tyrosine kinases 2-signal transducers and activators of transcription 3 axis by suppressing growth hormone receptor gene." -target gene hsa-let-7e Multiple Myeloma 30230597 "The miR-125a-3p, miR-125a-5p, miR-99b-5p, and let-7e were powerful miRNAs correlating with the FGFR3, MAP1B, MYRIP, and CDC42BPA under the relevance analysis in the subnetwork." -target gene hsa-mir-125a Multiple Myeloma 30230597 "The miR-125a-3p, miR-125a-5p, miR-99b-5p, and let-7e were powerful miRNAs correlating with the FGFR3, MAP1B, MYRIP, and CDC42BPA under the relevance analysis in the subnetwork." -target gene hsa-mir-99b Multiple Myeloma 30230597 "The miR-125a-3p, miR-125a-5p, miR-99b-5p, and let-7e were powerful miRNAs correlating with the FGFR3, MAP1B, MYRIP, and CDC42BPA under the relevance analysis in the subnetwork." -target gene hsa-mir-143 Heart Failure 30230713 "miR-143 (P? T might contribute to the increased risk and poor prognosis of NSCLC, highlighting the importance of rs767649 in the prevention and therapy of NSCLC." -therapeutic target hsa-mir-145 Bladder Neoplasms 26544536 "Taken together, our results identified that lncRNA-UCA1 enhances bladder cancer cell migration and invasion in part through the hsa-miR-145/ZEB1/2/FSCN1 pathway. Therefore, lncRNA-UCA1 might act as a promising therapeutic target for the invasion and metastasis of bladder cancer." -therapeutic target hsa-mir-137 Gastric Neoplasms 26545111 "In conclusion, the results reinforced the critical role for the down-regulated miR-137 expression in gastric cancer and suggested that miR-137 expression could be a prognostic indicator for this disease. In addition, these patients with TNM stage III gastric cancer and low miR-137 expression might need more aggressive postoperative treatment and closer follow-up." -therapeutic target hsa-mir-362 "Leukemia, Myelogenous, Chronic, BCR-ABL Positive" 26545365 "miR-362-5p acts as an oncomiR that down-regulates GADD45¦Á, which consequently activates the JNK1/2 and P38 signalling. This finding provides novel insights into CML leukaemogenesis and may help identify new diagnostic and therapeutic targets." -therapeutic target hsa-mir-134 Atherosclerosis 26546816 "Collectively, our findings indicate that miR-134 may regulate lipid accumulation and proinfiammatory cytokine secretion in macrophages by targeting the ANGPTL4 gene. Our results have also suggested a promising and potential therapeutic target for atherosclerosis." -therapeutic target hsa-mir-9 "Carcinoma, Hepatocellular" 26547929 "Our study suggests that miR-9 functions as a tumor suppressor in HCC progression by inhibiting a series of target genes, including the newly validated miR-9/IGF2BP1/AKT&ERK axis, thus providing potential therapeutic targets and novel prognostic biomarkers for HCC patients." -therapeutic target hsa-mir-326 "Carcinoma, Lung, Non-Small-Cell" 26548724 "Our study demonstrated a direct target relationship between NSBP1 and miR-326 through which miR-326 inhibited cell proliferation and invasion of NSCLC cells. Thus, miR-326-NSBP1 is a promising candidate target for developing novel anticancer therapeutics for NSCLC." -therapeutic target hsa-mir-296 "Carcinoma, Lung, Non-Small-Cell" 26549165 "Taken together, the present study indicated that miR-296-5p regulated PLK1 expression and could function as a tumor suppressor in NSCLC progression, which provides a potential target for gene therapy of NSCLC." -therapeutic target hsa-mir-146b Osteosarcoma 26549292 "These results indicated that miR-146b-5p promoted proliferation, migration and invasiveness. It also increased resistance to chemotherapy through the regulation of ZNRF3, and suggested novel potential therapeutic targets for the treatment of osteosarcoma." -therapeutic target hsa-mir-885 Neoplasms [unspecific] 26554827 Our work shows how DNp73 promotes cancer stem-like features and provides a mechanistic rationale to target the DNp73-IGF1R cascade as a therapeutic strategy to eradicate CSC. -therapeutic target hsa-mir-506 Glioma 26554866 "These results showed that miR-506 functions as a tumor suppressor in glioma by targeting STAT3, suggesting that miR-506 may serve as a potential target in the treatment of human glioma." -therapeutic target hsa-mir-143 "Adenocarcinoma, Pancreatic Ductal" 26554910 "miRNA expression profiles should be investigated to evaluate the potential function as biomarkers for early diagnosis, disease progression, response to therapy, and prognosis because of their characteristics of high stability, tissue specificity and ease of availability." -therapeutic target hsa-mir-145 "Adenocarcinoma, Pancreatic Ductal" 26554910 "miRNA expression profiles should be investigated to evaluate the potential function as biomarkers for early diagnosis, disease progression, response to therapy, and prognosis because of their characteristics of high stability, tissue specificity and ease of availability." -therapeutic target hsa-mir-96 "Adenocarcinoma, Pancreatic Ductal" 26554910 "miRNA expression profiles should be investigated to evaluate the potential function as biomarkers for early diagnosis, disease progression, response to therapy, and prognosis because of their characteristics of high stability, tissue specificity and ease of availability." -therapeutic target hsa-mir-320a Osteoporosis 26555194 "We identified two osteoblast miRNAs over-expressed in osteoporotic fractures, which opens novel prospects for research and therapy." -therapeutic target hsa-mir-483 Osteoporosis 26555194 "We identified two osteoblast miRNAs over-expressed in osteoporotic fractures, which opens novel prospects for research and therapy." -therapeutic target hsa-mir-101 "Squamous Cell Carcinoma, Esophageal" 26556718 "Overexpression of miR-101 in ESCC inhibits proliferation and metastasis. Therefore, the miR-101/COX-2 pathway might be a therapeutic target in ESCC." -therapeutic target hsa-mir-543 Hypertension 26562529 "In summary, our study suggested that the downregulation of the miR-543 could alleviate the insulin resistance via the modulation of the SIRT1 expression, which might be a potential new strategy for treating insulin resistance and a promising therapeutic method for hypertension." -therapeutic target hsa-mir-182 Breast Neoplasms 26563369 downregulation of miR-182 might find therapeutical value for overcoming trastuzumab resistance. -therapeutic target hsa-mir-3175 Neoplasms [unspecific] 26565624 "Our results suggest that HOXB1 functions as a tumor suppressor, regulated by miR-3175 in glioma. These results clarify the pathogenesis of glioma and offer a potential target for its treatment." -therapeutic target hsa-mir-186 "Squamous Cell Carcinoma, Esophageal" 26568291 "Our findings established that the miR-186 has a suppressive role in ESCC progression via SKP2-mediated pathway, and this implies that miR-186 could be a potential therapeutic target for ESCC." -therapeutic target hsa-mir-224 Cholangiocarcinoma 26573191 IL-6 may promote the invasive and metastatic properties of CCA through upregulated miR-224. Studies of the differentially expressed serum miRNAs in CCA may help to further elucidate the pathogenic processes of this disease and aid in the development of a novel and effective therapeutic strategy. -therapeutic target hsa-mir-1246 Colorectal Carcinoma 26573378 "Consequently, these findings provided a molecular basis for the role of miR-1246/CCNG2 in the progression of human CRC and suggested a novel target for the treatment of CRC." -therapeutic target hsa-mir-340 Breast Neoplasms 26573744 "In brief, miR-340 plays an important role in breast cancer progression. Thus, miR-340 may be further explored as a novel biomarker for breast cancer metastasis and prognosis,and potentially a therapeutic target." -therapeutic target hsa-mir-124 Prostate Neoplasms 26573802 "Taken together, our results offer a preclinical rationale to evaluate miR-124 for cancer treatment." -therapeutic target hsa-mir-27b Gastric Neoplasms 26576539 These results show that miR-27b-3p suppresses ROR1 expression through the binding site in the 3'UTR inhibiting the cell proliferation. These findings indicate that miR-27b-3p exerts tumor-suppressive effects in GC through the suppression of oncogene ROR1 expression and suggest a therapeutic application of miR-27b-3p in GC. -therapeutic target hsa-mir-449a Gastric Neoplasms 26576674 "Our results demonstrated that miR-449a suppressed Flot2 expression results in decreased cell invasion through repressing TGF-¦Â-mediated-EMT, and provides a new theoretical basis to further investigate miR-449a-regulated Flot2 as a potential biomarker and a promising approach for GC treatment." -therapeutic target hsa-mir-634 Ovarian Neoplasms 26576679 miR-634 levels determine chemosensitivity in ovarian cancer cells. We identify miR-634 as a therapeutic candidate to resensitize chemotherapy resistant ovarian tumors. -therapeutic target hsa-mir-34a Neoplasms [unspecific] 26580663 microRNA-34a as a Therapeutic Agent against Human Cancer. -therapeutic target hsa-mir-1274a Breast Neoplasms 26581147 "Biomarkers of DNA repair and cell cycle control can identify patients at high risk of treatment failure in those receiving radiation therapy for early breast cancer in independent cohorts. These should be further investigated prospectively, especially TOP2A and SKP2, for which targeted therapies are available." -therapeutic target hsa-mir-139 Breast Neoplasms 26581147 "Biomarkers of DNA repair and cell cycle control can identify patients at high risk of treatment failure in those receiving radiation therapy for early breast cancer in independent cohorts. These should be further investigated prospectively, especially TOP2A and SKP2, for which targeted therapies are available." -therapeutic target hsa-mir-148a "Carcinoma, Lung, Non-Small-Cell" 26584284 Evidence from this study demonstrated that miR-148a exerts tumor-suppressive effects in NSCLC and suggests a new therapeutic option for NSCLC. -therapeutic target hsa-mir-203 Osteosarcoma 26584294 "Taken together, these findings suggest that miR-203 acts as a tumor suppressor via regulation of TBK1 expression in OS progression, and miR-203 may be a promising therapeutic target for OS." -therapeutic target hsa-mir-4792 "Carcinoma, Nasopharyngeal" 26585487 "These findings suggest that miR-4792 functions as a tumor suppressor in NPC development and progression by targeting FOXC1, which could act as a novel potential therapeutic target for NPC treatment,and miR-4792/FOXC1 pathway that we studied might be used for NPC treatment in future." -therapeutic target hsa-mir-125b Endomyocardial Fibrosis 26585673 "In conclusion, miR-125b is critical for induction of cardiac fibrosis and acts as a potent repressor of multiple anti-fibrotic mechanisms.Inhibition of miR-125b may represent a novel therapeutic approach for the treatment of human cardiac fibrosis and other fibrotic diseases." -therapeutic target hsa-mir-143 Lung Neoplasms 26586766 "This study shows that miR-143/145 expressed from the tumor microenvironment stimulates neoangiogenesis and supports tumor expansion in the lung, demonstrating a surprising role for the putative tumor suppressor miRNA cluster in promoting tumorigenesis. We propose inhibition of miR-143/145 as a therapeutic avenue to modulate tumor neoangiogenesis." -therapeutic target hsa-mir-145 Lung Neoplasms 26586766 "This study shows that miR-143/145 expressed from the tumor microenvironment stimulates neoangiogenesis and supports tumor expansion in the lung, demonstrating a surprising role for the putative tumor suppressor miRNA cluster in promoting tumorigenesis. We propose inhibition of miR-143/145 as a therapeutic avenue to modulate tumor neoangiogenesis." -therapeutic target hsa-mir-155 Pneumonia 26589478 Our findings suggest that antagonizing certain microRNA might serve as a potential therapeutic strategy against secondary bacterial infection. -therapeutic target hsa-mir-27a Breast Neoplasms 26592661 Our findings provide a novel anti-tumor mechanism of ATO involved in miR-27a for the treatment of breast cancer. -therapeutic target hsa-mir-9 "Carcinoma, Lung, Non-Small-Cell" 26593208 "These findings suggest that oncogenic miR-9 targeted FoxO1 to promote cell growth, and downregulation of this axis was involved in erlotinib's growth inhibitory effects. Clarifying the regulation of miRNAs by erlotinib may indicate novel strategies for enhancing EGFR-targeted cancer therapy." -therapeutic target hsa-mir-148a "Carcinoma, Hepatocellular" 26599259 miR-148a is an inhibitor of the I¦ÊB kinase alpha/NUMB/NOTCH pathway and an inducer of hepatocytic differentiation that when deregulated promotes HCC initiation and progression. Differentiation-targeted therapy may be a promising strategy to treat and prevent HCC. -therapeutic target hsa-mir-184 Ovarian Neoplasms 26601424 "Altogether, our results suggest that miR-184 together with pathologic diagnosis is critical for prognosis determination in EOC patients and help select treatment strategy." -therapeutic target hsa-mir-100 "Adenocarcinoma, Pancreatic Ductal" 26606261 "Consistent miR expression profiles, in part regulated by mutant TP53 gene, were identified in gemcitabine-resistant PDAC with significant MRP-1 and Bcl-2 overexpression. These results provide a basis for further elucidation of chemoresistance mechanisms and therapeutic approaches to overcome chemoresistance in PDAC." -therapeutic target hsa-mir-125b "Adenocarcinoma, Pancreatic Ductal" 26606261 "Consistent miR expression profiles, in part regulated by mutant TP53 gene, were identified in gemcitabine-resistant PDAC with significant MRP-1 and Bcl-2 overexpression. These results provide a basis for further elucidation of chemoresistance mechanisms and therapeutic approaches to overcome chemoresistance in PDAC." -therapeutic target hsa-mir-138 "Adenocarcinoma, Pancreatic Ductal" 26606261 "Consistent miR expression profiles, in part regulated by mutant TP53 gene, were identified in gemcitabine-resistant PDAC with significant MRP-1 and Bcl-2 overexpression. These results provide a basis for further elucidation of chemoresistance mechanisms and therapeutic approaches to overcome chemoresistance in PDAC." -therapeutic target hsa-mir-21 "Adenocarcinoma, Pancreatic Ductal" 26606261 "Consistent miR expression profiles, in part regulated by mutant TP53 gene, were identified in gemcitabine-resistant PDAC with significant MRP-1 and Bcl-2 overexpression. These results provide a basis for further elucidation of chemoresistance mechanisms and therapeutic approaches to overcome chemoresistance in PDAC." -therapeutic target hsa-mir-210 "Adenocarcinoma, Pancreatic Ductal" 26606261 "Consistent miR expression profiles, in part regulated by mutant TP53 gene, were identified in gemcitabine-resistant PDAC with significant MRP-1 and Bcl-2 overexpression. These results provide a basis for further elucidation of chemoresistance mechanisms and therapeutic approaches to overcome chemoresistance in PDAC." -therapeutic target hsa-mir-31 "Adenocarcinoma, Pancreatic Ductal" 26606261 "Consistent miR expression profiles, in part regulated by mutant TP53 gene, were identified in gemcitabine-resistant PDAC with significant MRP-1 and Bcl-2 overexpression. These results provide a basis for further elucidation of chemoresistance mechanisms and therapeutic approaches to overcome chemoresistance in PDAC." -therapeutic target hsa-mir-330 "Adenocarcinoma, Pancreatic Ductal" 26606261 "Consistent miR expression profiles, in part regulated by mutant TP53 gene, were identified in gemcitabine-resistant PDAC with significant MRP-1 and Bcl-2 overexpression. These results provide a basis for further elucidation of chemoresistance mechanisms and therapeutic approaches to overcome chemoresistance in PDAC." -therapeutic target hsa-mir-378 "Adenocarcinoma, Pancreatic Ductal" 26606261 "Consistent miR expression profiles, in part regulated by mutant TP53 gene, were identified in gemcitabine-resistant PDAC with significant MRP-1 and Bcl-2 overexpression. These results provide a basis for further elucidation of chemoresistance mechanisms and therapeutic approaches to overcome chemoresistance in PDAC." -therapeutic target hsa-mir-99a "Adenocarcinoma, Pancreatic Ductal" 26606261 "Consistent miR expression profiles, in part regulated by mutant TP53 gene, were identified in gemcitabine-resistant PDAC with significant MRP-1 and Bcl-2 overexpression. These results provide a basis for further elucidation of chemoresistance mechanisms and therapeutic approaches to overcome chemoresistance in PDAC." -therapeutic target hsa-mir-140 Osteoarthritis 26608362 miR-29a and miR-140 combination treatment may be a possible treatment for OA -therapeutic target hsa-mir-22 Gastric Neoplasms 26610210 These findings provide a better understanding of the development and progression of GC and may be an important implication for future therapy of the GC. -therapeutic target hsa-mir-543 Gastric Neoplasms 26612257 "Our results identify a new regulatory mechanism of miR-543 on SIRT1 expression in gastric cancer, and raise the possibility that the miR-543/SIRT1 pathway may serve as a potential target for the treatment of gastric cancer." -therapeutic target hsa-mir-20b "Carcinoma, Hepatocellular" 26612965 "The whole study suggests that miR-20b, HIF-1¦Á, and VEGF serve as a potential therapeutic agent for hepatocellular carcinoma." -therapeutic target hsa-mir-142 Peritoneal Fibrosis 26616819 These results suggest that several miRNAs are involved in PF and that they may be useful as novel diagnostic biomarkers and therapeutic targets for PF. -therapeutic target hsa-mir-21 Peritoneal Fibrosis 26616819 These results suggest that several miRNAs are involved in PF and that they may be useful as novel diagnostic biomarkers and therapeutic targets for PF. -therapeutic target hsa-mir-221 Peritoneal Fibrosis 26616819 These results suggest that several miRNAs are involved in PF and that they may be useful as novel diagnostic biomarkers and therapeutic targets for PF. -therapeutic target hsa-mir-223 Peritoneal Fibrosis 26616819 These results suggest that several miRNAs are involved in PF and that they may be useful as novel diagnostic biomarkers and therapeutic targets for PF. -therapeutic target hsa-mir-34a Peritoneal Fibrosis 26616819 These results suggest that several miRNAs are involved in PF and that they may be useful as novel diagnostic biomarkers and therapeutic targets for PF. -therapeutic target hsa-mir-96 "Carcinoma, Thyroid, Papillary" 26617698 "The data from the present study demonstrated that miR-96 can promote proliferation, and inhibit apoptosis in PTC cell lines K1 and TPC1, thus miR-96 may play an oncogenic role in PTC by inhibiting the FOXO1 and regulating AKT/FOXO1/Bim pathway, and it may serve as a novel therapeutic target for miRNA-based PTC therapy." -therapeutic target hsa-mir-200a "Carcinoma, Hepatocellular" 26617701 "Our study reveals an important role of miR-200a in inhibiting EMT,proliferation and migration in HCC cells, suggesting the possibility of miR-200a-based therapeutics in HCC." -therapeutic target hsa-mir-299 Lung Neoplasms 26617714 "Therefore, the disordered decreased of miR-299-3p and resulting ABCE1 up-expression may contribute to chemoresistance of lung cancer, and miR-299-3p-ABCE1 may represent a new potential therapeutic target for the treatment of chemoresistance of lung cancer." -therapeutic target hsa-mir-101 "Carcinoma, Cervical" 26617722 "MiR-101 likely acts as a tumor suppressor in cervical cancer.Overexpression of miR-101 decreased expression of its target gene Cox-2 and inhibited proliferation and invasion, and promoted apoptosis to suppress tumorigenicity. MiR-101 is a promising new target for the development of therapeutic strategies for the clinical treatment of cervical cancer." -therapeutic target hsa-mir-126 Glioma 26617742 "Taken together, these findings showed that miR-126 functions as a tumor suppressor in glioma cells by targeting IRS-1 expression via the PI3K/AKT signaling pathways, suggesting that miR-126 might be a novel target for therapeutic strategies in glioma." -therapeutic target hsa-mir-10b "Carcinoma, Renal Cell, Clear-Cell" 26617769 Our results suggest that miR-10b plays a tumor-suppressive role in ccRCC. Demethylation of miR-10b may be therapeutically beneficial for ccRCC treatment. -therapeutic target hsa-mir-374a Osteosarcoma 26617789 "Our study suggested that miR-374a functions as an oncogene in OS, and the miR-374a/Axin2 axis might represent a potential therapeutic target for OS intervention." -therapeutic target hsa-mir-142 "Carcinoma, Lung, Non-Small-Cell" 26617792 These results suggest that miR-142-3p may be a tumor suppressor through the downregulation of HMGB1 in NSCLC. miR-142-3p may be a tumor suppressor and a potential therapeutic agent for patients with NSCLC. -therapeutic target hsa-mir-137 "Carcinoma, Lung, Non-Small-Cell" 26617798 "Taken together, our findings suggested that miR-137/BMP7 axis could contribute to the progression of NSCLC, suggesting miR-137 as a potential therapeutic target for the treatment of NSCLC." -therapeutic target hsa-mir-338 Gastric Neoplasms 26617808 "Our study suggested that miR-338-3p is significantly decreased in gastric cancer, and inhibits cell proliferation, migration and invasion partially via the downregulation of ADAM17. Thus, miR-338-3p may represent a potential therapeutic target for gastric cancer intervention." -therapeutic target hsa-mir-185 "Carcinoma, Lung, Non-Small-Cell" 26617940 "Collectively, we conclude that miR-185 has a critical function by blocking AKT1 in NSCLC cells, and it may be a novel therapeutic agent for miRNA based NSCLC therapy." -therapeutic target hsa-mir-140 Glioma 26619802 "Taken together, we have demonstrated the fact that knockdown of MALAT1 resulted in the increased permeability of BTB, which might contribute to establishing potential therapeutic strategies for human gliomas." -therapeutic target hsa-mir-34a Multiple Myeloma 26620594 Delivery of miR-34a by chitosan/PLGA nanoplexes for the anticancer treatment of multiple myeloma. -therapeutic target hsa-mir-152 Gastric Neoplasms 26627200 "TGF-¦Â could induce HLA-G expression in GC by inhibiting miR-152,involving its negative regulation on HLA-G. Since TGF-¦Â induced HLA-G up-regulation plays important role in immune escape, a potential application of miR-152 was suggested in GC treatment, or miR-152 might be one potential biomarker for GC." -therapeutic target hsa-mir-17 "Carcinoma, Breast, Triple Negative" 26629823 "Our results imply that therapeutic antisense sequences against miRNAs should be designed to target the miRNA strand with the greatest number of putative binding sites in the target mRNAs, while minimizing affinity for the minor strand." -therapeutic target hsa-mir-133a Gastric Neoplasms 26629938 These outcomes might be secondary to the increased expression of miR-133a after the treatment with UA. -therapeutic target hsa-mir-15a Melanoma 26631117 Our results support a key role of IL-10R¦Á in the development and progression of melanoma and suggest that the IL-10/IL-10 receptor system may become a new therapeutic target for melanoma treatment. -therapeutic target hsa-mir-185 Melanoma 26631117 Our results support a key role of IL-10R¦Á in the development and progression of melanoma and suggest that the IL-10/IL-10 receptor system may become a new therapeutic target for melanoma treatment. -therapeutic target hsa-mir-211 Melanoma 26631117 Our results support a key role of IL-10R¦Á in the development and progression of melanoma and suggest that the IL-10/IL-10 receptor system may become a new therapeutic target for melanoma treatment. -therapeutic target hsa-mir-409 Breast Neoplasms 26631969 "Our data collectively indicate that miR-409-3p functions as a tumor suppressor in BC through downregulating Akt1, supporting the targeting of the novel miR-409-3p/Akt1 axis as a potentially effective therapeutic approach for BC." -therapeutic target hsa-mir-145 Prostate Neoplasms 26632856 This novel study shows a role for miR-145 in modulating radiosensitivity in vivo and highlights the need for further study investigating the potential role of miR-145 as both a predictive marker of response and a novel therapeutic agent with which to enhance the efficacy of radiation therapy. -therapeutic target hsa-mir-324 Cardiovascular Diseases [unspecific] 26633713 "Our study defines the NFAT4/ miR-324-5p/Mtfr1 axis, which participates in the regulation of mitochondrial fission and cardiomyocyte apoptosis, and suggests potential new treatment avenues for cardiac diseases." -therapeutic target hsa-mir-122 Liver Diseases [unspecific] 26636761 "Taken together, our study indicates that miR-122 may downregulate cytokine production in HSCs and macrophage chemotaxis and that the targeting of miR-122 may have therapeutic potential for preventing the progression of liver diseases." -therapeutic target hsa-mir-424 "Carcinoma, Endometrial" 26638889 "Taken together, our study suggests that increased miR-424 suppresses E2-induced cell growth, and providing a potential therapeutic target for estrogen-associated endometrial carcinoma." -therapeutic target hsa-mir-134 Lung Neoplasms 26642897 "Altogether, our data demonstrated an altered expression of two development-related miRNAs namely miR-134 and miR-187 in lung tumors for the first time. Moreover we have shown that miR-134 and miR-187 expression alternation were in accordance with their approved regulatory roles, therefore these miRNAs could serve as new biomarkers with potential usefulness in lung cancer diagnosis and treatments. In addition, miR-187 expression in tumor cells could perturb cell cycle which supported its possible role as tumor suppressor." -therapeutic target hsa-mir-187 Lung Neoplasms 26642897 "Altogether, our data demonstrated an altered expression of two development-related miRNAs namely miR-134 and miR-187 in lung tumors for the first time. Moreover we have shown that miR-134 and miR-187 expression alternation were in accordance with their approved regulatory roles, therefore these miRNAs could serve as new biomarkers with potential usefulness in lung cancer diagnosis and treatments. In addition, miR-187 expression in tumor cells could perturb cell cycle which supported its possible role as tumor suppressor." -therapeutic target hsa-mir-150 "Leukemia, Myeloid" 26644403 "Our findings indicate that decreased KLF4 expression mediates antileukemic effects through regulation of gene and microRNA networks,containing miR-150, CDKN1A, and MYC, and provide mechanistic support for therapeutic strategies increasing KLF4 expression." -therapeutic target hsa-mir-33a Atherosclerosis 26645139 "This review summarizes the current understanding of the functions of miR-33a/b and the progress in miRNA therapeutics for treatment of various diseases, including atherosclerosis." -therapeutic target hsa-mir-33b Atherosclerosis 26645139 "This review summarizes the current understanding of the functions of miR-33a/b and the progress in miRNA therapeutics for treatment of various diseases, including atherosclerosis." -therapeutic target hsa-mir-23b Diabetic Nephropathy 26646104 "Taken together, we showed for the first time that miR-23b acts as a suppressor of EMT in diabetic nephropathy through repressing PI3K-AKT signalling pathway activation by targeting HMGA2, which maybe a potential therapeutic target for diabetes-induced renal dysfunction." -therapeutic target hsa-mir-103 "Carcinoma, Hepatocellular" 26646106 "These findings indicate that miR-103 potentially acts as an oncogene in HCC by inhibiting AKAP12 expression and raise the possibility that miR-103 increases telomerase activity by increasing PKC¦Á activity. Thus, miR-103 may represent a new potential diagnostic and therapeutic target for HCC treatment." -therapeutic target hsa-mir-362 Kidney Neoplasms 26647877 "These results suggested that miR-362-3p functions as a tumor suppressor in RCC, and may serve as a potential molecular target in the treatment of RCC." -therapeutic target hsa-mir-21 Diabetes Mellitus 26655730 These results suggest that endogenous miRNAs involved in the formation of IPCs from PPCs should be considered in the development of an effective cell transplant therapy for diabetes. -therapeutic target hsa-mir-340 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 26656176 "Taken together, these data suggest that miR-340 impedes LSCC progression by targeting EZH2 with the possible mechanism to enhance the expression of anti-oncogene p27 and suppress PI3K/Akt activation, providing a novel target and a potential therapeutic pathway against LSCC." -therapeutic target hsa-mir-204 Breast Neoplasms 26656364 Our study reveals that Sam68 is regulated by miR-204 and may play an important role in the self-renewal of BCSCs via activating the Wnt/beta-catenin pathway. Sam68 may represent a novel therapeutic target for breast cancer. -therapeutic target hsa-mir-126 Thrombosis 26659078 Overexpressed miR-126 inhibits apoptosis of VECs and DVT through targeting the anti-apoptotic pathway PI3K/Akt via PIK3R2.GENERAL SIGNIFICANCE: These findings may provide a new target for the therapy of DVT. -therapeutic target hsa-mir-215 Pancreatic Neoplasms 26662405 "These findings indicate that miR-215 may act as a tumor suppressor in pancreatic cancer cells, and could serve as a novel therapeutic target for miR-based therapy." -therapeutic target hsa-mir-548d Breast Neoplasms 26663100 Our study showed that miR-548d-3p/TP53BP2 pathway is critically involved in the proliferation and apoptosis of breast cancer cells and may be new therapeutic target of breast cancer cells. -therapeutic target hsa-mir-146a Allergy 26663191 "Further characterization of microRNA functions is important, as similar to other conditions, the modulation of microRNA expression could potentially be used for therapeutic purposes in allergic diseases in the future. In addition, miRNAs could be implemented as biomarkers for endotyping complex allergic conditions." -therapeutic target hsa-mir-155 Allergy 26663191 "Further characterization of microRNA functions is important, as similar to other conditions, the modulation of microRNA expression could potentially be used for therapeutic purposes in allergic diseases in the future. In addition, miRNAs could be implemented as biomarkers for endotyping complex allergic conditions." -therapeutic target hsa-mir-21 Allergy 26663191 "Further characterization of microRNA functions is important, as similar to other conditions, the modulation of microRNA expression could potentially be used for therapeutic purposes in allergic diseases in the future. In addition, miRNAs could be implemented as biomarkers for endotyping complex allergic conditions." -therapeutic target hsa-mir-214 Breast Neoplasms 26666173 MiR-214 increased the sensitivity of breast cancer cells to TAM and FUL through inhibition of autophagy by targeting UCP2. MiR-214 shows potential as a novel therapeutic strategy for overcoming endocrine resistance in ER(+) breast cancers. -therapeutic target hsa-mir-1 Arrhythmia 26671473 "We aim at emphasizing the relationship between miR-1 and ion channels and proteins involved in the process of arrhythmia. In addition, we will pay attention to its future therapeutic prospects." -therapeutic target hsa-mir-21 Breast Neoplasms 26676464 "Taken together, we provide novel evidence that miR-21 knockdown suppresses cell growth, migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer. p85¦Á downregulation defined a specific subgroup of breast cancer with shorter 5-year DFS and OS, which may require more aggressive treatment." -therapeutic target hsa-mir-34a "Carcinoma, Breast, Triple Negative" 26676753 "Together, our results demonstrate that miR-34a exerts potent antitumorigenic effects in vitro and in vivo and suggests that miR-34a replacement therapy, which is currently being tested in human clinical trials, represents a promising therapeutic strategy for TNBC." -therapeutic target hsa-mir-186 Multiple Myeloma 26679605 "Our collective results clearly indicate that miR-186 functions as a tumor suppressor in MM, supporting its potential as a therapeutic target for the disease." -therapeutic target hsa-mir-134 Osteosarcoma 26681023 These findings indicate that miR-134 may act as a tumor suppressor in osteosarcoma and could serve as a novel therapeutic agent for miRNA-based therapy. -therapeutic target hsa-mir-181c Glioblastoma 26682928 "our study found that miR-181c plays a key role in glioblastoma cell invasion, migration and mesenchymal transition suggesting potential therapeutic applications." -therapeutic target hsa-mir-555 Viral Infectious Disease 26683768 These findings provide the first evidence for the role of miR-555 in PV replication and reveal that miR-555 could contribute to the development of antiviral therapeutic strategies against PV. -therapeutic target hsa-mir-1290 "Leukemia, Lymphoblastic, Acute, B-Cell" 26684414 "Our results identify an expression profile of miR-151-5p, miR-451, and miR-1290 as a novel biomarker for outcome in pediatric precursor B-cell ALL patients, regardless of treatment protocol. The use of these markers may lead to improved risk stratification at diagnosis and allow early therapeutic interventions in an attempt to improve survival of high risk patients." -therapeutic target hsa-mir-151 "Leukemia, Lymphoblastic, Acute, B-Cell" 26684414 "Our results identify an expression profile of miR-151-5p, miR-451, and miR-1290 as a novel biomarker for outcome in pediatric precursor B-cell ALL patients, regardless of treatment protocol. The use of these markers may lead to improved risk stratification at diagnosis and allow early therapeutic interventions in an attempt to improve survival of high risk patients." -therapeutic target hsa-mir-451 "Leukemia, Lymphoblastic, Acute, B-Cell" 26684414 "Our results identify an expression profile of miR-151-5p, miR-451, and miR-1290 as a novel biomarker for outcome in pediatric precursor B-cell ALL patients, regardless of treatment protocol. The use of these markers may lead to improved risk stratification at diagnosis and allow early therapeutic interventions in an attempt to improve survival of high risk patients." -therapeutic target hsa-mir-125b Lung Neoplasms 26686386 these results show tremendous promise of wt-p53 and miR-125b gene therapy using dual CD44/EGFR-targeting HA NP vector for effective treatment of lung cancer. -therapeutic target hsa-mir-122 Cholangiocarcinoma 26686459 "MiR-122 expression was significantly weaker in CC tissues, and miR-122 overexpression might play pivotal roles in inhibiting proliferation, stimulating apoptosis and suppressing invasion of CC cells, suggesting a new target for CC diagnosis and treatment." -therapeutic target hsa-mir-145 "Adenocarcinoma, Lung" 26687391 "MicroRNA 25, microRNA 145, and microRNA 210 as biomarkers for predicting the efficacy of maintenance treatment with pemetrexed in lung adenocarcinoma patients who are negative for epidermal growth factor receptor mutations or anaplastic lymphoma kinase translocations." -therapeutic target hsa-mir-210 "Adenocarcinoma, Lung" 26687391 "MicroRNA 25, microRNA 145, and microRNA 210 as biomarkers for predicting the efficacy of maintenance treatment with pemetrexed in lung adenocarcinoma patients who are negative for epidermal growth factor receptor mutations or anaplastic lymphoma kinase translocations." -therapeutic target hsa-mir-25 "Adenocarcinoma, Lung" 26687391 "MicroRNA 25, microRNA 145, and microRNA 210 as biomarkers for predicting the efficacy of maintenance treatment with pemetrexed in lung adenocarcinoma patients who are negative for epidermal growth factor receptor mutations or anaplastic lymphoma kinase translocations." -therapeutic target hsa-mir-21 "Squamous Cell Carcinoma, Head and Neck" 26690371 miR-21 cooperates with CDK5 to promote EMT and invasion in HNSCC.This finding suggests that CDK5 may be an important cofactor for targeting when designing metastasis-blocking therapy by targeting STAT3/miR-21 axis with STAT3 inhibitor or miR-21 antisense oligonucleotide. This is the first demonstration of the novel role of STAT3/miR-21 axis and CDK5/CDK5R1 (p35) in metastasis of HNSCC. -therapeutic target hsa-mir-1914 Colorectal Carcinoma 26695693 Plasma miR-1914* and -1915 interact with NFIX RNA and reduce its level in chemoresistant CRC cells to first-line chemotherapy. Up-regulation of miR-1914* and -1915 decreased the chemoresistance abilities of chemoresistant CRC cells. The plasma miR-1914* and -1915 may play a role in colorectal cancer therapy and diagnosis. -therapeutic target hsa-mir-1915 Colorectal Carcinoma 26695693 Plasma miR-1914* and -1915 interact with NFIX RNA and reduce its level in chemoresistant CRC cells to first-line chemotherapy. Up-regulation of miR-1914* and -1915 decreased the chemoresistance abilities of chemoresistant CRC cells. The plasma miR-1914* and -1915 may play a role in colorectal cancer therapy and diagnosis. -therapeutic target hsa-mir-155 Rheumatoid Arthritis 26697483 "Taken together, our results suggest that genome editing of miR-155 holds the potential as a therapeutic strategy in RA." -therapeutic target hsa-mir-146a Allergic Rhinitis 26700406 miR-146a can enforce OVA-specific immunotherapy via inducing antigen-specific regulatory T cells. miR-146a may have therapeutic potential to be used in the immunotherapy of allergic diseases. -therapeutic target hsa-mir-224 Breast Neoplasms 26701615 "Our results indicate that FUT4 and miR-224-3p are crucial regulators of cancer response to chemotherapy, and may serve as therapeutic targets to reverse chemotherapy resistance in breast cancer." -therapeutic target hsa-mir-613 Prostate Neoplasms 26703210 "In conclusion, our study suggests that miR-613 functions as a tumor suppressor, partially through targeting Fzd7, and is a potential therapeutic target for prostate cancer." -therapeutic target hsa-mir-195 Sepsis 26704614 "Silencing of miR-195 reduced multiple-organ injury and improved the survival in sepsis, and the protective effects of miR-195 inhibition were associated with upregulation of Bcl-2, Sirt1, and Pim-1. Thus, inhibition of miR-195 may represent a new therapeutic approach for sepsis." -therapeutic target hsa-mir-127 Osteosarcoma 26707641 "Overall, the results revealed that miR-127-3p acts as a tumor suppressor and that its down-regulation in cancer may contribute to OS progression and metastasis, suggesting that miR-127-3p could be a potential therapeutic target in the treatment of OS." -therapeutic target hsa-mir-127 "Carcinoma, Hepatocellular" 26708147 "In summary, we found that miR-127-5p suppressed NF-¦ÊB activity by directly targeting BLVRB in HCC cells, and this finding improves our understanding of the molecular mechanism of inflammation-induced HCC growth and proliferation and the successful inhibition of NF-¦ÊB activity by cancer treatment." -therapeutic target hsa-mir-221 Glioma 26708164 increased pro-apoptotic effects were obtained with the co-administration of both anti-miRâ€?21 and anti-miRâ€?22 PNAs. -therapeutic target hsa-let-7b "Leukemia, Lymphoblastic, Acute" 26708866 "In the patients with ALL, the expression of microRNA let-7b is regulated by methylation of CpG islands in the region of genomic promoter. The microRNA let-7b may act as a tumor suppressor, whose low expression is involved in ALL development, indicating the microRNA let-7b may become a new therapeutic target for ALL." -therapeutic target hsa-mir-192 "Carcinoma, Hepatocellular" 26710269 "These results elucidate that the miR-192/-204-HOTTIP axis might be an important molecular pathway during hepatic cell tumorigenesis. Our data in clinical HCC samples highlight miR-192, miR-204 and HOTTIP with prognostic and potentially therapeutic implications." -therapeutic target hsa-mir-204 "Carcinoma, Hepatocellular" 26710269 "These results elucidate that the miR-192/-204-HOTTIP axis might be an important molecular pathway during hepatic cell tumorigenesis. Our data in clinical HCC samples highlight miR-192, miR-203 and HOTTIP with prognostic and potentially therapeutic implications." -therapeutic target hsa-let-7 Breast Neoplasms 26717565 "Taken together, these findings provide evidence that a miRNA expression signature can be developed to aid existing methods to determine the risk of recurrence for women with estrogen receptor positive breast cancers treated with endocrine therapy." -therapeutic target hsa-mir-3648 Breast Neoplasms 26717565 "Taken together, these findings provide evidence that a miRNA expression signature can be developed to aid existing methods to determine the risk of recurrence for women with estrogen receptor positive breast cancers treated with endocrine therapy." -therapeutic target hsa-mir-377 Breast Neoplasms 26717565 "Taken together, these findings provide evidence that a miRNA expression signature can be developed to aid existing methods to determine the risk of recurrence for women with estrogen receptor positive breast cancers treated with endocrine therapy." -therapeutic target hsa-mir-548t Breast Neoplasms 26717565 "Taken together, these findings provide evidence that a miRNA expression signature can be developed to aid existing methods to determine the risk of recurrence for women with estrogen receptor positive breast cancers treated with endocrine therapy." -therapeutic target hsa-mir-633b Breast Neoplasms 26717565 "Taken together, these findings provide evidence that a miRNA expression signature can be developed to aid existing methods to determine the risk of recurrence for women with estrogen receptor positive breast cancers treated with endocrine therapy." -therapeutic target hsa-mir-340 Prostate Neoplasms 26718483 "Our findings suggest that miR-340 may function as a novel tumor suppressor in PCa through the MDM2-p53 pathway by directly targeting MDM2, which may be a promising miRNA-targeted therapy for PCa." -therapeutic target hsa-mir-142 Fungal Keratitis 26720440 "This is, to our knowledge, the first report on comprehensive human corneal miRNA expression profile in fungal keratitis. Several miRNAs with high expression in fungal keratitis point toward their potential role in regulation of pathogenesis. Further insights in understanding their role in corneal wound inflammation may help design new therapeutic strategies." -therapeutic target hsa-mir-155 Fungal Keratitis 26720440 "This is, to our knowledge, the first report on comprehensive human corneal miRNA expression profile in fungal keratitis. Several miRNAs with high expression in fungal keratitis point toward their potential role in regulation of pathogenesis. Further insights in understanding their role in corneal wound inflammation may help design new therapeutic strategies." -therapeutic target hsa-mir-451a Fungal Keratitis 26720440 "This is, to our knowledge, the first report on comprehensive human corneal miRNA expression profile in fungal keratitis. Several miRNAs with high expression in fungal keratitis point toward their potential role in regulation of pathogenesis. Further insights in understanding their role in corneal wound inflammation may help design new therapeutic strategies." -therapeutic target hsa-mir-511 Fungal Keratitis 26720440 "This is, to our knowledge, the first report on comprehensive human corneal miRNA expression profile in fungal keratitis. Several miRNAs with high expression in fungal keratitis point toward their potential role in regulation of pathogenesis. Further insights in understanding their role in corneal wound inflammation may help design new therapeutic strategies." -therapeutic target hsa-mir-142 Inflammation 26721185 "These results suggest that PPAR¦Ã-mediated upregulation of miR-142-3p inhibits the HMGB1 expression, which,in turn, is a novel anti-inflammatory mechanism of PPAR¦Ã and has an important role in the treatment of inflammatory diseases." -therapeutic target hsa-mir-16 Glioma 26722459 "In conclusion, MiR-16 mediated temozolomide-resistance in glioma cells by modulation of apoptosis via targeting Bcl-2, which suggesting that miR-16 and Bcl-2 would be potential therapeutic targets for glioma therapy." -therapeutic target hsa-mir-212 Habitual Abortion 26722471 "In summary, we describe a unique myometrial miRNA expression pattern in human spontaneous preterm labor and discuss their possible role by predicting the target genes of each miRNA. Our results suggest that miRNA play a critical role in the process of partuition in myometrium. The identification of myometrial miRNA profile throws a new light upon the molecule mechanism and provides an insight into the potential diagnosis and treatment of preterm labor." -therapeutic target hsa-mir-223 Habitual Abortion 26722471 "In summary, we describe a unique myometrial miRNA expression pattern in human spontaneous preterm labor and discuss their possible role by predicting the target genes of each miRNA. Our results suggest that miRNA play a critical role in the process of partuition in myometrium. The identification of myometrial miRNA profile throws a new light upon the molecule mechanism and provides an insight into the potential diagnosis and treatment of preterm labor." -therapeutic target hsa-mir-5096 Habitual Abortion 26722471 "In summary, we describe a unique myometrial miRNA expression pattern in human spontaneous preterm labor and discuss their possible role by predicting the target genes of each miRNA. Our results suggest that miRNA play a critical role in the process of partuition in myometrium. The identification of myometrial miRNA profile throws a new light upon the molecule mechanism and provides an insight into the potential diagnosis and treatment of preterm labor." -therapeutic target hsa-mir-503 Colorectal Carcinoma 26722476 "miR-503 inhibits cell proliferation and induces apoptosis by directly targeting E2F3 in CRC cells, indicating its potential application in CRC diagnosis and therapy." -therapeutic target hsa-mir-203 Melanoma 26722525 "This study for the first time provided evidence that miR-203 could be an independent potential prognostic marker for patients with melanoma, and might even become a new therapeutic target for the treatment of melanoma." -therapeutic target hsa-mir-542 Bladder Neoplasms 26723509 "MiR-542-3p and its target gene survivin may play crucial roles in the aggressive progression of human bladder cancer. More interestingly, miR-542-3p may function as a tumor suppressor and inhibit the proliferation of bladder cancer cells, implying that miR-542-3p-survivin signal axis might be a novel therapeutic target of this disease." -therapeutic target hsa-mir-126 Rheumatoid Arthritis 26723864 "Our study demonstrated that down-regulation of miR-126 may indirectly inhibit PI3K/AKT signaling pathway to disrupt the imbalance between growth and death of RASFs by targeting PIK3R2, which may be clinically helpful to find therapeutic strategies directed toward miR-126 function for RA patients." -therapeutic target hsa-mir-302b Breast Neoplasms 26744520 "Collectively, our findings reveal new insights underlying increased breast cancer mortality in obese individuals and provide a novel preclinical rationale to test the efficacy of Src inhibitors for breast cancer treatment." -therapeutic target hsa-mir-26b Lung Neoplasms 26744864 "Taken together, our results demonstrate that miR-26b could suppress lung cancer cells proliferation, migration and invasion by directly negative regulation of COX-2. MiR-26b could serve as a novel potential marker for NSCLC therapy." -therapeutic target hsa-mir-483 Glaucoma 26747772 "MicroRNA-483-3p has an inhibitory effect on ECM production in HTMCs through downregulating Smad4, which indicates that miR-483-3p may serve as a potential therapeutic target in glaucoma." -therapeutic target hsa-mir-28 "Carcinoma, Hepatocellular" 26754294 A miR-28-5p-IL-34-macrophage feedback loop modulates HCC metastasis and serves as a novel prognostic factor as well as a therapeutic target for HCC. -therapeutic target hsa-mir-208a Lung Neoplasms 26754670 "The present study provides evidence that miR-208a can affect the proliferation and radiosensitivity of human lung cancer cells by targeting p21 and can be transported by exosomes. Thus, miR-208a may serve as a potential therapeutic target for lung cancer patients." -therapeutic target hsa-mir-511 "Leukemia, Myeloid, Acute" 26762252 Our study provides new insights into the understanding of miRNAs as functional mediators of the leukemogenic fusion gene MLL-AF9 and opens new opportunities to further investigate specific therapeutic options for AML via the miRNA level. -therapeutic target hsa-mir-548c Ovarian Neoplasms 26762267 "These findings suggest that miR-548c directly downregulates Twist,and provide a novel mechanism for Twist upregulation in both endometrial and ovarian cancers. The use of miR-548c may hold therapeutic potential for the treatment of Twist-overexpressing tumors." -therapeutic target hsa-mir-125a "Carcinoma, Cervical" 26766902 The molecular pathway of miR-125a-5p/ABL2 plays an important role in human cervical carcinoma. Targeting miR-125a-5p/ABL2 pathway may provide a new treatment strategy for patients with cervical carcinoma. -therapeutic target hsa-mir-15a Uterine Leiomyosarcoma 26768834 "Differential miRNA signatures of ESS and LMS provide novel data regarding transcriptional regulation in these cancers, based on which new potential diagnostic markers, prognostic biomarkers and therapeutic targets may be explored. Differences in miRNA profiles of primary and metastatic LMS may improve our understanding of disease progression in this aggressive malignancy." -therapeutic target hsa-mir-31 Uterine Leiomyosarcoma 26768834 "Differential miRNA signatures of ESS and LMS provide novel data regarding transcriptional regulation in these cancers, based on which new potential diagnostic markers, prognostic biomarkers and therapeutic targets may be explored. Differences in miRNA profiles of primary and metastatic LMS may improve our understanding of disease progression in this aggressive malignancy." -therapeutic target hsa-mir-92a Uterine Leiomyosarcoma 26768834 "Differential miRNA signatures of ESS and LMS provide novel data regarding transcriptional regulation in these cancers, based on which new potential diagnostic markers, prognostic biomarkers and therapeutic targets may be explored. Differences in miRNA profiles of primary and metastatic LMS may improve our understanding of disease progression in this aggressive malignancy." -therapeutic target hsa-mir-103 Prostate Neoplasms 26771762 "Therefore, our data collectively demonstrate that miR-103 is a proto-oncogene miRNA that can suppress prostate cancer proliferation and migration by down-regulating the oncogene PDCD10, indicating that miR-103 may represent a new potential diagnostic and therapeutic target for prostate cancer treatment." -therapeutic target hsa-let-7 Hemangioma 26772808 microRNA-regulated pathways may play a role in infantile hemangioma development and progression and may be potentially useful for future development of novel therapeutic strategies for patients with infantile hemangioma. -therapeutic target hsa-mir-9 Hemangioma 26772808 microRNA-regulated pathways may play a role in infantile hemangioma development and progression and may be potentially useful for future development of novel therapeutic strategies for patients with infantile hemangioma. -therapeutic target hsa-mir-939 Hemangioma 26772808 microRNA-regulated pathways may play a role in infantile hemangioma development and progression and may be potentially useful for future development of novel therapeutic strategies for patients with infantile hemangioma. -therapeutic target hsa-mir-367 "Carcinoma, Hepatocellular" 26772880 "This study indicated that miR-367 negatively regulates PTEN and promotes proliferation and invasion of HCC cells. Thus, miR-367 may represent a potential therapeutic target for HCC intervention." -therapeutic target hsa-mir-1182 Bladder Neoplasms 26772886 "In conclusion, these results demonstrate that miR-1182 acts as a tumor suppressor and may be a potential biomarker for bladder cancer diagnosis and treatment." -therapeutic target hsa-mir-206 "Carcinoma, Cervical" 26775359 "miR-206 may act not only as a novel diagnostic and prognostic marker, but also as a potential target for molecular therapy of cervical cancer." -therapeutic target hsa-mir-451 "Carcinoma, Renal Cell" 26779781 MiR-451 acts as an anti-oncogene in RCC. Our data offer a new therapeutic target for further research. -therapeutic target hsa-mir-509 Ovarian Neoplasms 26786897 Our data suggest that restoring certain dysregulated miRNAs to their normal levels could increase the therapeutic effects of anticancer drugs. -therapeutic target hsa-mir-211 Melanoma 26787841 "These findings highlight a novel mechanism of melanoma formation: miR-211 is a molecular switch that is turned off in melanoma cells, raising the hope that in the future we might be able to turn the switch back on, thus providing a better treatment option for melanoma." -therapeutic target hsa-mir-508 "Carcinoma, Gastric" 26801246 All these findings supports that canonical NF-¦ÊB signaling pathway is activated in GC at least by the inactivation of miR-508-3p and this might have therapeutic potential in GC treatment. -therapeutic target hsa-mir-483 Thrombosis 26801758 "miR-483-3p is upregulated in EPCs from DVT patients, and it targets SRF to decrease EPCs migration and tube formation and increase apoptosis in vitro, while decrease EPCs homing and thrombus resolution in vivo. MiR-483-3p is a potential therapeutic target in DVT treatment." -therapeutic target hsa-mir-206 "Carcinoma, Renal Cell" 26808577 All these results suggested that miR-206 functioned as a novel cell cycle regulator and tumor suppressor in ccRCC and could be considered as a potential target for ccRCC therapy. -therapeutic target hsa-mir-205 Prostate Neoplasms 26813458 The miR-205/TP53INP1 mediated autophagy pathway might be an important molecular mechanism regulating radiosensitivity of prostate cancer cells and represents a potential therapeutic target for prostate cancer. -therapeutic target hsa-mir-130a "Carcinoma, Hepatocellular" 26817584 "Our findings provide a molecular insight on understanding drug resistance in HCC cells. Therefore, activation of miR-130a-3p or inactivation of Smad4 could be a novel approach for the treatment of HCC." -therapeutic target hsa-mir-107 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 26822763 NEAT1 plays an oncogenic role in the tumorigenesis of LSCC and may serve as a potential target for therapeutic intervention. -therapeutic target hsa-mir-122 Cholangiocarcinoma 26825606 "The results indicate that HNF6 may serve as a tumor suppressor by regulating miR-122, and its overexpression may represent a mechanism-based therapy for CCA." -therapeutic target hsa-mir-23b Gastric Neoplasms 26835790 "Our results indicated that plasma miR-23b was overexpressed in GC patients and high plasma miR-23b expression was associated with poor clinical outcome. Thus, plasma miR-23b may serve as a potential diagnostic biomarker and therapeutic target for GC." -therapeutic target hsa-mir-124 Medulloblastoma 26840408 "In all, we have discovered miR-124 to be downregulated in instances of medulloblastoma in which Nur77 is upregulated, resulting in a proliferative state that abets cancer progression. This study provides evidence for increasing miR-124 expression as a potential therapy for cancers with elevated levels of Nur77." -therapeutic target hsa-mir-24 Prostate Neoplasms 26847530 These findings provide evidence that miR-24 has a tumor suppressor role in prostate cancer and also targets p27 and p16 in prostate cancer cells. We propose that it may be a useful progression biomarker or focus of therapeutic intervention for this disease. -therapeutic target hsa-mir-200c Cholangiocarcinoma 26855082 The ability of the combined PCX/miR-200c treatment to obstruct two migratory pathways represents a promising antimetastatic strategy in cholangiocarcinoma. -therapeutic target hsa-mir-183 "Carcinoma, Cervical" 26873866 "In conclusion, our study revealed that miR-183 might be a tumor suppressor via inhibiting the invasion and metastasis of cervical cancer cells through targeting MMP-9, indicating that miR-183 may be a novel potential therapeutic target for cervical cancer." -therapeutic target hsa-mir-21 Asthma 26874829 "This study suggested that serum miRNA-21 is stable and detectable in serum of asthmatic children, which could promise potential biomarker in diagnosis as well as in response to therapy of asthma." -therapeutic target hsa-mir-874 Colorectal Carcinoma 26875895 "These data demonstrate that miR-874 functions as a tumor suppressor by repression of STAT3, suggesting its potential therapeutic value in CRC treatment." -therapeutic target hsa-mir-100 Multiple Sclerosis 26943961 Dicer and microRNA expression in multiple sclerosis and response to interferon therapy. -therapeutic target hsa-mir-107 Multiple Sclerosis 26943961 Dicer and microRNA expression in multiple sclerosis and response to interferon therapy. -therapeutic target hsa-mir-145 Multiple Sclerosis 26943961 Dicer and microRNA expression in multiple sclerosis and response to interferon therapy. -therapeutic target hsa-mir-146b Multiple Sclerosis 26943961 Dicer and microRNA expression in multiple sclerosis and response to interferon therapy. -therapeutic target hsa-mir-323 Multiple Sclerosis 26943961 Dicer and microRNA expression in multiple sclerosis and response to interferon therapy. -therapeutic target hsa-mir-3614 Multiple Sclerosis 26943961 Dicer and microRNA expression in multiple sclerosis and response to interferon therapy. -therapeutic target hsa-mir-369 Multiple Sclerosis 26943961 Dicer and microRNA expression in multiple sclerosis and response to interferon therapy. -therapeutic target hsa-mir-494 Multiple Sclerosis 26943961 Dicer and microRNA expression in multiple sclerosis and response to interferon therapy. -therapeutic target hsa-mir-874 Multiple Sclerosis 26943961 Dicer and microRNA expression in multiple sclerosis and response to interferon therapy. -therapeutic target hsa-mir-9 Multiple Sclerosis 26943961 Dicer and microRNA expression in multiple sclerosis and response to interferon therapy. -therapeutic target hsa-mir-146a Atherosclerosis 26956647 delivery of microRNA (miR)-146a and miR-181b with an E-selectin-targeting multistage vector (ESTA-MSV) to inflamed endothelium covering atherosclerotic plaques inhibits atherosclerosis -therapeutic target hsa-mir-181b Atherosclerosis 26956647 delivery of microRNA (miR)-146a and miR-181b with an E-selectin-targeting multistage vector (ESTA-MSV) to inflamed endothelium covering atherosclerotic plaques inhibits atherosclerosis -therapeutic target hsa-mir-146b Glioma 26983831 a novel treatment whereby mesenchymal stromal cells were employed to package tumor-suppressing miR-146b into exosomes -therapeutic target hsa-mir-708 Asthma 26998837 These results demonstrate that miR-708 and miR-140-3p exert distinct effects on inflammation-associated gene expression and biological function of ASM cells. Targeting these miRNA networks may provide a novel therapeutic mechanism to down-regulate airway inflammation and ASM proliferation in asthma. -therapeutic target hsa-mir-124 Stroke 27031810 These neuroprotective and anti-inflammatory effects of the early miR-124 treatment were pronounced during the first week with Arg-1. -therapeutic target hsa-mir-122 "Carcinoma, Hepatocellular" 27059462 "MicroRNA profiling of distinct tumor foci, coupled with methods that address within-subject tumor heterogeneity, has the potential to significantly improve prediction of HCC recurrence post-transplantation. The development of a clinically applicable HCC biomarker would inform treatment options for patients and contribute to liver transplant selection criteria for practitioners." -therapeutic target hsa-mir-126 "Carcinoma, Hepatocellular" 27059462 "MicroRNA profiling of distinct tumor foci, coupled with methods that address within-subject tumor heterogeneity, has the potential to significantly improve prediction of HCC recurrence post-transplantation. The development of a clinically applicable HCC biomarker would inform treatment options for patients and contribute to liver transplant selection criteria for practitioners." -therapeutic target hsa-mir-15a "Carcinoma, Hepatocellular" 27059462 "MicroRNA profiling of distinct tumor foci, coupled with methods that address within-subject tumor heterogeneity, has the potential to significantly improve prediction of HCC recurrence post-transplantation. The development of a clinically applicable HCC biomarker would inform treatment options for patients and contribute to liver transplant selection criteria for practitioners." -therapeutic target hsa-mir-22 "Carcinoma, Hepatocellular" 27059462 "MicroRNA profiling of distinct tumor foci, coupled with methods that address within-subject tumor heterogeneity, has the potential to significantly improve prediction of HCC recurrence post-transplantation. The development of a clinically applicable HCC biomarker would inform treatment options for patients and contribute to liver transplant selection criteria for practitioners." -therapeutic target hsa-mir-30a "Carcinoma, Hepatocellular" 27059462 "MicroRNA profiling of distinct tumor foci, coupled with methods that address within-subject tumor heterogeneity, has the potential to significantly improve prediction of HCC recurrence post-transplantation. The development of a clinically applicable HCC biomarker would inform treatment options for patients and contribute to liver transplant selection criteria for practitioners." -therapeutic target hsa-mir-146a Melanoma 27059647 "two miRNAs that are particularly relevant in human melanoma progression, miR-146a and miR-214." -therapeutic target hsa-mir-205 Breast Neoplasms 27064979 Variations in serum miRNA levels during NAC treatment may be therapeutically significant for predicting response and survival outcomes. -therapeutic target hsa-mir-21 Breast Neoplasms 27064979 Variations in serum miRNA levels during NAC treatment may be therapeutically significant for predicting response and survival outcomes. -therapeutic target hsa-mir-3200 Breast Neoplasms 27064979 Variations in serum miRNA levels during NAC treatment may be therapeutically significant for predicting response and survival outcomes. -therapeutic target hsa-mir-451 Breast Neoplasms 27064979 Variations in serum miRNA levels during NAC treatment may be therapeutically significant for predicting response and survival outcomes. -therapeutic target hsa-mir-21 Glioblastoma 27079911 Here we show that rationally designed hammerhead ribozymes and DNAzymes can target miR-21 and/or its precursors. -therapeutic target hsa-mir-21 Glioma 27079911 Here we show that rationally designed hammerhead ribozymes and DNAzymes can target miR-21 and/or its precursors. -therapeutic target hsa-mir-24 Diabetic Vasculopathy 27085480 elevation of miR-24 in vascular system may be a novel therapeutic strategy to prevent the development of diabetic atherosclerosis. -therapeutic target hsa-mir-23a Acute Erythroid Leukemia 27086927 "indicating the therapeutic significance of miR-23a, -27a and -24 for AEL treatment." -therapeutic target hsa-mir-24 Acute Erythroid Leukemia 27086927 "indicating the therapeutic significance of miR-23a, -27a and -24 for AEL treatment." -therapeutic target hsa-mir-27a Acute Erythroid Leukemia 27086927 "indicating the therapeutic significance of miR-23a, -27a and -24 for AEL treatment." -therapeutic target hsa-mir-487b Lung Neoplasms 27097129 miR-487b-5p inhibition can be further explored as a chemotherapy target in the treatment of TMZ-resistant lung carcinoma. -therapeutic target hsa-mir-17 Prostate Neoplasms 27125502 RNA nanoparticles were constructed by bottom-up self-assembly containing the anti-prostate-specific membrane antigen (PSMA) RNA aptamer as a targeting ligand and anti-miR17 or anti-miR21 as therapeutic modules. -therapeutic target hsa-mir-21 Prostate Neoplasms 27125502 RNA nanoparticles were constructed by bottom-up self-assembly containing the anti-prostate-specific membrane antigen (PSMA) RNA aptamer as a targeting ligand and anti-miR17 or anti-miR21 as therapeutic modules. -therapeutic target hsa-mir-96 "Carcinoma, Breast, Triple Negative" 27170187 3 directly engages pri-miR-96 in breast cancer cells. -therapeutic target hsa-mir-29b Multiple Myeloma 27196750 miR-29b-based epi-therapeutic approaches in the treatment of this malignancy -therapeutic target hsa-mir-124 Breast Neoplasms 27266580 miR-124-M-Oba may have potential applications in breast cancer therapy. -therapeutic target hsa-mir-21 Glioblastoma 27277750 co-delivery of anti-miR-21 significantly improved accumulation of LPNs in the nucleus of U87MG cells. -therapeutic target hsa-mir-150 "Leukemia, Myeloid, Acute" 27280396 "using FLT3L-guided miR-150-based nanoparticles, to treat FLT3-overexpressing AML with high efficacy and minimal side effects." -therapeutic target hsa-mir-181a Mitochondrial Metabolism Disease 27281615 Knock down of endogenous miR-181a accelerates the autophagic degradation of damaged mitochondria. -therapeutic target hsa-mir-222 Breast Neoplasms 27282281 downregulation of miR-222 in MCF-7/Adr increased sensitivity to Adr and Adr-induced apoptosis -therapeutic target hsa-mir-215 Cervical Neoplasms 27295129 "dysregulation of miR-29C, miR-34A, miR-98, and miR-215" -therapeutic target hsa-mir-29c Cervical Neoplasms 27295129 "dysregulation of miR-29C, miR-34A, miR-98, and miR-215" -therapeutic target hsa-mir-34a Cervical Neoplasms 27295129 "dysregulation of miR-29C, miR-34A, miR-98, and miR-215" -therapeutic target hsa-mir-98 Cervical Neoplasms 27295129 "dysregulation of miR-29C, miR-34A, miR-98, and miR-215" -therapeutic target hsa-mir-155 Lung Neoplasms 27315591 Inhibition of microRNA-155 sensitizes lung cancer cells to irradiation -therapeutic target hsa-mir-150 Graft-Versus-Host Disease 27329362 microRNA-150 (miR-150) induces immunological tolerance in CD4(+) T cells after transplantation -therapeutic target hsa-mir-18a "Carcinoma, Breast, Triple Negative" 27338043 MiR-18a overexpression significantly increased PTX IC50 and reduced PTX induced cell apoptosis -therapeutic target hsa-mir-93 Age-Related Macular Degeneration 27349759 these results highlight the therapeutic potential of miR-93 -therapeutic target hsa-mir-21 Glioblastoma 27355932 Anti-cancer effect of R3V6 peptide-mediated delivery of an anti-microRNA-21 antisense-oligodeoxynucleotide in a glioblastoma animal model. -therapeutic target hsa-mir-20a Gastric Neoplasms 27357419 Altering miRâ€?0a expression may be a potential therapeutic strategy for the treatment of chemoresistance in GC in the future. -therapeutic target hsa-mir-221 "Leukemia, Lymphoblastic, Acute" 27358112 Niche-influenced miR-221/222 may define a novel therapeutic target in ALL -therapeutic target hsa-mir-222 "Leukemia, Lymphoblastic, Acute" 27358112 Niche-influenced miR-221/222 may define a novel therapeutic target in ALL -therapeutic target hsa-mir-30e Gastric Neoplasms 27372603 DIM may through the miR-30e-ATG5 modulating autophagy inhibit the proliferation of gastric cancer cells. -therapeutic target hsa-mir-493 Breast Neoplasms 27375041 The miR-493-5p/FUT4 pathway has therapeutic potential in breast cancer. -therapeutic target hsa-mir-30e Glioblastoma 27388765 "Collectively, combination of miR-30e and PAC is a promising therapeutic strategy to inhibit autophagy and increase apoptosis in GSC and SNB19 cells." -therapeutic target hsa-mir-210 Acute Myocardial Infarction 27392480 "HAR could reduce the infarction area, alleviate the interstitial fibrosis and improve the cardiac function of AMI rats. Those effects could be related to promoting myocardium angiogenesis of HAR by up-regulating miR-210 and VEGF." -therapeutic target hsa-mir-155 Colitis 27395764 IL-10/miR-155/SHIP-1 pathways play a critical role in commensal bacteria induced colitis and miR-15 -therapeutic target hsa-mir-214 Breast Neoplasms 27422604 "In conclusion, miR-214 functions as a tumor suppressor by regulating the RFWD2-p53 cascade, thus delivery of miR-214 analogs could be a potential adjunct therapy in breast cancer harboring wild type p53." -therapeutic target hsa-mir-21 Neoplasms [unspecific] 27428511 Targeted inhibition of oncogenic miR-21 maturation with designed RNA-binding proteins -therapeutic target hsa-mir-7 Melanoma 27448964 "Collectively, our study demonstrated that miR-7 could reverse the resistance to BRAF inhibitors in certain vemurafenib resistant melanoma cell lines." -therapeutic target hsa-mir-145 "Carcinoma, Colon" 27482839 "The results in this work show that miR-145 has been effectively delivered to colon carcinomas through a PLGA/PEI/HA vehicle, indicating a promising miRNA replacement therapy strategy." -therapeutic target hsa-mir-122 Asthma 27485847 "First clinical trials using the blockade of liver specific miR-122 showed very promising results in the treatment of chronic hepatitis C virus infection. Results of preclinical and animal studies are also promising providing future rationale for the development of new therapeutics for various internal diseases including heart failure, bronchial asthma or inflammatory bowel diseases." -therapeutic target hsa-mir-122 Chronic Hepatitis C 27485847 "First clinical trials using the blockade of liver specific miR-122 showed very promising results in the treatment of chronic hepatitis C virus infection. Results of preclinical and animal studies are also promising providing future rationale for the development of new therapeutics for various internal diseases including heart failure, bronchial asthma or inflammatory bowel diseases." -therapeutic target hsa-mir-122 Heart Failure 27485847 "First clinical trials using the blockade of liver specific miR-122 showed very promising results in the treatment of chronic hepatitis C virus infection. Results of preclinical and animal studies are also promising providing future rationale for the development of new therapeutics for various internal diseases including heart failure, bronchial asthma or inflammatory bowel diseases." -therapeutic target hsa-mir-122 Inflammatory Bowel Diseases 27485847 "First clinical trials using the blockade of liver specific miR-122 showed very promising results in the treatment of chronic hepatitis C virus infection. Results of preclinical and animal studies are also promising providing future rationale for the development of new therapeutics for various internal diseases including heart failure, bronchial asthma or inflammatory bowel diseases." -therapeutic target hsa-mir-145 Pancreatic Neoplasms 27507554 "miR-145 re-expression resulted in downregulation of MUC13, HER2, pAKT, and inhibition of cell proliferation, clonogenicity, migration, and invasion of pancreatic cancer cells." -therapeutic target hsa-mir-21 Glioblastoma 27508339 Coinhibition of miR-21 and miR-10b significantly reduced the number of viable cells (by 24%; p < 0.01) and increased (2.9-fold) cell cycle arrest at G2/M phase upon Temozolomide treatment in U87 MG cells. -therapeutic target hsa-mir-146b "Carcinoma, Thyroid, Papillary" 27533309 "In conjunction with current therapeutic regimens, targeting the miR-146b-IRAK1 axis may provide a potential approach for PTC management." -therapeutic target hsa-mir-146b Neoplasms [unspecific] 27533309 "In conjunction with current therapeutic regimens, targeting the miR-146b-IRAK1 axis may provide a potential approach for PTC management." -therapeutic target hsa-mir-223 Periodontal Diseases 27552373 "Knowledge gained from future studies will be beneficial in developing alternative therapeutic approaches, especially ones that use miRNA delivery systems to treat periodontal disease" -therapeutic target hsa-mir-22 Rhabdomyosarcoma 27569217 Deep Sequencing Reveals a Novel miR-22 Regulatory Network with Therapeutic Potential in Rhabdomyosarcoma. -therapeutic target hsa-mir-34a Glioblastoma 27569663 Functionalized nanogels carrying an anticancer microRNA for glioblastoma therapy. -therapeutic target hsa-let-7i Neoplasms [unspecific] 27588466 Involvement of let-7 microRNA for the therapeutic effects of Rhenium-188-embedded liposomal nanoparticles on orthotopic human head and neck cancer model. -therapeutic target hsa-mir-143 Obesity 27623943 Tumour biology of obesity-related cancers: understanding the molecular concept for better diagnosis and treatment. -therapeutic target hsa-mir-1246 Corneal Neovascularization 27625050 Curcumin inhibits angiogenesis by up-regulation of microRNA-1275 and microRNA-1246: a promising therapy for treatment of corneal neovascularization. -therapeutic target hsa-mir-1275 Corneal Neovascularization 27625050 Curcumin inhibits angiogenesis by up-regulation of microRNA-1275 and microRNA-1246: a promising therapy for treatment of corneal neovascularization. -therapeutic target hsa-mir-145 Neoplasms [unspecific] 27655328 "our results indicated that mir-145, through targeting its common potential targets, may significantly contribute to tumor pathogenesis in distinct cancer types and might serve as an important target for cancer therapy" -therapeutic target hsa-mir-193a Neoplasms [unspecific] 27669434 the broader applicability of using miR-193a-3p as a therapeutic agent to target KRas-mutant cancer -therapeutic target hsa-mir-495 Neoplasms [unspecific] 27697751 MiR-495 functions as an adjuvant to radiation therapy by reducing the radiation-induced bystander effect. -therapeutic target hsa-let-7a Colorectal Carcinoma 27737877 Our data support the role of let-7a in suppressing antitumor immunity in colorectal cancer and suggest let-7a as a potential target of immunotherapy -therapeutic target hsa-mir-124 Glioblastoma 27765835 Immune modulatory nanoparticle therapeutics for intracerebral glioma. -therapeutic target hsa-mir-155 Allergic Asthma 27783037 miR-155: A Novel Target in Allergic Asthma. -therapeutic target hsa-mir-129 Neoplasms [unspecific] 27802440 we summarized the roles of miR-129 family members and their target genes in tumorigenesis and clinical treatment of human cancers -therapeutic target hsa-mir-126 Kidney Injury 27832640 "non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have significant potential to aid the development of diagnostic and therapeutic strategies of AKI" -therapeutic target hsa-mir-127 Kidney Injury 27832640 "non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have significant potential to aid the development of diagnostic and therapeutic strategies of AKI" -therapeutic target hsa-mir-150 Kidney Injury 27832640 "non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have significant potential to aid the development of diagnostic and therapeutic strategies of AKI" -therapeutic target hsa-mir-21 Kidney Injury 27832640 "non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have significant potential to aid the development of diagnostic and therapeutic strategies of AKI" -therapeutic target hsa-mir-24 Kidney Injury 27832640 "non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have significant potential to aid the development of diagnostic and therapeutic strategies of AKI" -therapeutic target hsa-mir-30 Kidney Injury 27832640 "non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have significant potential to aid the development of diagnostic and therapeutic strategies of AKI" -therapeutic target hsa-mir-494 Kidney Injury 27832640 "non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have significant potential to aid the development of diagnostic and therapeutic strategies of AKI" -therapeutic target hsa-mir-687 Kidney Injury 27832640 "non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have significant potential to aid the development of diagnostic and therapeutic strategies of AKI" -therapeutic target hsa-mir-106a Rheumatoid Arthritis 27834806 "X-linked miRNAs, in the context of sex differences, might provide novel insight into new molecular mechanisms and potential therapeutic targets in RA for disease treatment and prevention" -therapeutic target hsa-mir-221 Rheumatoid Arthritis 27834806 "X-linked miRNAs, in the context of sex differences, might provide novel insight into new molecular mechanisms and potential therapeutic targets in RA for disease treatment and prevention" -therapeutic target hsa-mir-222 Rheumatoid Arthritis 27834806 "X-linked miRNAs, in the context of sex differences, might provide novel insight into new molecular mechanisms and potential therapeutic targets in RA for disease treatment and prevention" -therapeutic target hsa-mir-532 Rheumatoid Arthritis 27834806 "X-linked miRNAs, in the context of sex differences, might provide novel insight into new molecular mechanisms and potential therapeutic targets in RA for disease treatment and prevention" -therapeutic target hsa-mir-92a Rheumatoid Arthritis 27834806 "X-linked miRNAs, in the context of sex differences, might provide novel insight into new molecular mechanisms and potential therapeutic targets in RA for disease treatment and prevention" -therapeutic target hsa-mir-98 Rheumatoid Arthritis 27834806 "X-linked miRNAs, in the context of sex differences, might provide novel insight into new molecular mechanisms and potential therapeutic targets in RA for disease treatment and prevention" -therapeutic target hsa-mir-122 Diabetes Mellitus 27966196 "MicroRNAs 33, 122, and 208: a potential novel targets in the treatment of obesity, diabetes, and heart-related diseases." -therapeutic target hsa-mir-208 Diabetes Mellitus 27966196 "MicroRNAs 33, 122, and 208: a potential novel targets in the treatment of obesity, diabetes, and heart-related diseases." -therapeutic target hsa-mir-33 Diabetes Mellitus 27966196 "MicroRNAs 33, 122, and 208: a potential novel targets in the treatment of obesity, diabetes, and heart-related diseases." -therapeutic target hsa-mir-34a Neoplasms [unspecific] 28010900 Emergence of miR-34a in radiation therapy. -therapeutic target hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 28053325 Effects of miRNA-15 and miRNA-16 expression replacement in chronic lymphocytic leukemia: implication for therapy. -therapeutic target hsa-mir-16 "Leukemia, Lymphocytic, Chronic, B-Cell" 28053325 Effects of miRNA-15 and miRNA-16 expression replacement in chronic lymphocytic leukemia: implication for therapy. -therapeutic target hsa-mir-21 "Carcinoma, Breast" 28067096 Differential response of normal and transformed mammary epithelial cells to combined treatment of anti-miR-21 and radiation. -therapeutic target hsa-mir-30a Schizophrenia 28072411 The early growth response protein 1-miR-30a-5p-neurogenic differentiation factor 1 axis as a novel biomarker for schizophrenia diagnosis and treatment monitoring. -therapeutic target hsa-mir-21 Hypertrophic Scar 28075443 MicroRNA expression signature and the therapeutic effect of the microRNA?21 antagomir in hypertrophic scarring. -therapeutic target hsa-mir-21 Neoplasms [unspecific] 28096467 "Our results not only elucidate miR-21-mediated radioresistance, but also provide potential new targets for improving radiotherapy" -therapeutic target hsa-mir-1 Intrahepatic Cholangiocarcinoma 28098904 "has-miR-96, has-miR-1 and has-miR-25, may be potential therapeutic targets for the future treatment of ICC" -therapeutic target hsa-mir-25 Intrahepatic Cholangiocarcinoma 28098904 "has-miR-96, has-miR-1 and has-miR-25, may be potential therapeutic targets for the future treatment of ICC" -therapeutic target hsa-mir-96 Intrahepatic Cholangiocarcinoma 28098904 "has-miR-96, has-miR-1 and has-miR-25, may be potential therapeutic targets for the future treatment of ICC" -therapeutic target hsa-mir-647 "Carcinoma, Gastric" 28098914 "miR-647 exerts powerful antitumorigenic effects in?vitro and in?vivo, and may represent a promising therapeutic agent against GC" -therapeutic target hsa-mir-21 Glioblastoma 28109960 RNA Nanoparticle-Based Targeted Therapy for Glioblastoma through Inhibition of Oncogenic miR-21. -therapeutic target hsa-mir-141 "Carcinoma, Colon" 28112364 MicroRNA-141 inhibits tumor growth and minimizes therapy resistance in colorectal cancer. -therapeutic target hsa-mir-206 Alzheimer Disease 28123152 "miR-206-3p is involved in the anti-dementia effects of donepezil, and could be a novel pharmacological target for treating AD" -therapeutic target hsa-mir-21 Diabetic Nephropathy 28129112 Therapeutic miR-21 Silencing Ameliorates Diabetic Kidney Disease in Mice. -therapeutic target hsa-mir-31 "Carcinoma, Colon" 28147317 EZH2 expression is a prognostic biomarker in patients with colorectal cancer treated with anti-EGFR therapeutics. -therapeutic target hsa-mir-1254 "Squamous Cell Carcinoma, Oral" 28161631 miR-1254 is a potential target for the treatment of OSCCs -therapeutic target hsa-let-7b Melanoma 28167449 Curcumin and treatment of melanoma: The potential role of microRNAs. -therapeutic target hsa-mir-21 Melanoma 28167449 Curcumin and treatment of melanoma: The potential role of microRNAs. -therapeutic target hsa-mir-122 Neoplasms [unspecific] 28209991 MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. -therapeutic target hsa-mir-34 Neoplasms [unspecific] 28209991 MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. -therapeutic target hsa-mir-126 "Carcinoma, Renal Cell" 28257806 Pseudohypoxia induced by miR-126 deactivation promotes migration and therapeutic resistance in renal cell carcinoma. -therapeutic target hsa-mir-146b "Carcinoma, Thyroid, Papillary" 28294980 MicroRNA-146b: A Novel Biomarker and Therapeutic Target for Human Papillary Thyroid Cancer. -therapeutic target hsa-mir-223 Hematologic Neoplasms 28322994 "The role of miRNA-223 in cancer: Function, diagnosis and therapy." -therapeutic target hsa-mir-27b Neoplasms [unspecific] 28351320 Promising therapeutic role of miR-27b in tumor. -therapeutic target hsa-mir-30a Neoplasms [unspecific] 28359057 miR-30a may serve as a potential target in the diagnosis and therapy of human cancer -therapeutic target hsa-mir-383 Spinal Cord Injuries 28365701 Suppression of MicroRNA-383 Enhances Therapeutic Potential of Human Bone-Marrow-Derived Mesenchymal Stem Cells in Treating Spinal Cord Injury via GDNF. -therapeutic target hsa-mir-149 Colorectal Carcinoma 28370854 miR-149 may serve as a therapeutic target for colorectal cancer treatment -therapeutic target hsa-mir-138 Malignant Neoplasms [unspecific] 28378633 MiR-138: A promising therapeutic target for cancer. -therapeutic target hsa-mir-17 Kidney Diseases [unspecific] 28399020 Therapeutic microRNAs in polycystic kidney disease. -therapeutic target hsa-mir-146 Cardiovascular Diseases [unspecific] 28407626 Exogenous miRNA-146a Enhances the Therapeutic Efficacy of Human Mesenchymal Stem Cells by Increasing Vascular Endothelial Growth Factor Secretion in the Ischemia/Reperfusion-Injured Heart. -therapeutic target hsa-mir-126 Diabetes Mellitus 28440196 miR-126 as a Therapeutic Agent for Diabetes Mellitus. -therapeutic target hsa-mir-210 Neurilemmoma 28440459 miR-210 could be a potential marker for judging tumor malignancy and be taken as an effective target for clinical auxiliary treatment of neurilemmoma -therapeutic target hsa-mir-21 Pancreatic Neoplasms 28444967 Co-delivery of microRNA-21 antisense oligonucleotides and gemcitabine using nanomedicine for pancreatic cancer therapy. -therapeutic target hsa-mir-143 Neoplasms [unspecific] 28448866 Function of microRNA-143 in different signal pathways in cancer: New insights into cancer therapy. -therapeutic target hsa-mir-92a Diabetes Mellitus 28462946 Light-inducible antimiR-92a as a therapeutic strategy to promote skin repair in healing-impaired diabetic mice. -therapeutic target hsa-mir-130a Myocardial Infarction 28498815 The optimization of cell therapy by combinational application with apicidin-treated mesenchymal stem cells after myocardial infarction. -therapeutic target hsa-mir-373 Glioma 28617546 Down-expression of miR-373 predicts poor prognosis of glioma and could be a potential therapeutic target. -therapeutic target hsa-mir-200c Uterine Carcinosarcoma 28620240 miR-200c-driven Mesenchymal-To-Epithelial Transition is a Therapeutic Target in Uterine Carcinosarcomas. -therapeutic target hsa-mir-143 "Carcinoma, Breast, Triple Negative" 28621239 A microRNA signature associated with pathological complete response to novel neoadjuvant therapy regimen in triple-negative breast cancer. -therapeutic target hsa-mir-30a "Carcinoma, Breast, Triple Negative" 28621239 A microRNA signature associated with pathological complete response to novel neoadjuvant therapy regimen in triple-negative breast cancer. -therapeutic target hsa-mir-770 "Carcinoma, Breast, Triple Negative" 28621239 A microRNA signature associated with pathological complete response to novel neoadjuvant therapy regimen in triple-negative breast cancer. -therapeutic target hsa-mir-9 "Carcinoma, Breast, Triple Negative" 28621239 A microRNA signature associated with pathological complete response to novel neoadjuvant therapy regimen in triple-negative breast cancer. -therapeutic target hsa-mir-375 "Carcinoma, Hepatocellular" 28624193 MiR-375 and Doxorubicin Co-delivered by Liposomes for Combination Therapy of Hepatocellular Carcinoma. -therapeutic target hsa-mir-499 Cardiovascular Diseases [unspecific] 28627982 miRNAs as potential therapeutic targets and diagnostic biomarkers for cardiovascular disease with a particular focus on WO2010091204. -therapeutic target hsa-mir-629 Breast Neoplasms 28629464 miR-629-3p may serve as a novel biomarker and potential therapeutic target for lung metastases of triple-negative breast cancer. -therapeutic target hsa-mir-15a "Lymphoma, Follicular" 28653191 MicroRNA Dysregulation to Identify Novel Therapeutic Targets. -therapeutic target hsa-mir-26a Glaucoma 28685590 miR-26a plays an essential role in the formation of filtering tract scar and function as a potential drug target -therapeutic target hsa-mir-503 Endometriosis 28720098 "Arcyriaflavin a, a cyclin D1-cyclin-dependent kinase4 inhibitor, induces apoptosis and inhibits proliferation of human endometriotic stromal cells: a potential therapeutic agent in endometriosis" -therapeutic target hsa-mir-140 "Carcinoma, Lung, Non-Small-Cell" 28739724 Therapeutic Role of MiR-140-5p for the Treatment of Non-small Cell Lung Cancer. -therapeutic target hsa-mir-433 Endomyocardial Fibrosis 28740551 Modulating microRNAs as Novel Therapeutic Targets in Cardiac Fibrosis. -therapeutic target hsa-mir-145 "Carcinoma, Ovarian" 28804560 Using miR-145 mimics may be a rational approach for therapeutic applications in ovarian carcinoma in the future -therapeutic target hsa-mir-132 Wound Healing 28807666 MicroRNA-132 with Therapeutic Potential in Chronic Wounds. -therapeutic target hsa-mir-122 "Leukemia, Myeloid, Acute" 28822593 Decreased expression of microRNA-122 is associated with an unfavorable prognosis in childhood acute myeloid leukemia and function analysis indicates a therapeutic potential. -therapeutic target hsa-mir-122 Cholangiocarcinoma 28832247 "miRNA profiling for diagnosis, prognosis and stratification of cancer treatment in cholangiocarcinoma." -therapeutic target hsa-mir-34b "Carcinoma, Thyroid" 28840508 It could be a target for developing treatment strategies of thyroid carcinoma with aggressive clinical behaviour -therapeutic target hsa-mir-21 Glioblastoma 28840962 Biomarkers and therapeutic advances in glioblastoma multiforme. -therapeutic target hsa-mir-155 Intraductal Papillary Mucinous Neoplasms 28938594 these miRNAs might serve as new risk biomarkers of IPMN and could be useful for future targeted therapies -therapeutic target hsa-mir-137 Bipolar Disorder 28969861 "miRNA findings in BD significantly vary between studies, but are consistent to suggest a key role for these molecules in BD's pathophysiology and treatment, particularly miR-34a and miR-137" -therapeutic target hsa-mir-34a Bipolar Disorder 28969861 "miRNA findings in BD significantly vary between studies, but are consistent to suggest a key role for these molecules in BD's pathophysiology and treatment, particularly miR-34a and miR-137" -therapeutic target hsa-mir-20a Myeloma 28979138 miR-20a plays a crucial role in the biology of MM and represents a potential target for novel therapies for MM patients -therapeutic target hsa-mir-122 Chronic Hepatitis C 28993299 Circulating microRNAs as a biomarker to predict therapy efficacy in hepatitis C patients with different genotypes. -therapeutic target hsa-mir-124a Glioblastoma 29016843 Mesenchymal stem cells as natural biofactories for exosomes carrying miR-124a in the treatment of gliomas. -therapeutic target hsa-mir-132 Colon Neoplasms 29017096 miR-132 as a promising therapeutic candidate to control autoimmune inflammation and tumorigenesis in CAC patients -therapeutic target hsa-mir-449a Neoplasms [unspecific] 29023247 miR-449a: a potential therapeutic agent for cancer. -therapeutic target hsa-mir-146a "Carcinoma, Thyroid, Papillary" 29048684 miR-146a and miR-146b in the diagnosis and prognosis of papillary thyroid carcinoma. -therapeutic target hsa-mir-146b "Carcinoma, Thyroid, Papillary" 29048684 miR-146a and miR-146b in the diagnosis and prognosis of papillary thyroid carcinoma. -therapeutic target hsa-mir-134 Epilepsy 29069823 MicroRNA-134 plasma levels before and after treatment with valproic acid for epilepsy patients. -therapeutic target hsa-mir-16 Cardiovascular Diseases [unspecific] 29104843 miR-16 was a potential therapeutic target by participating in the Ang II-associated multiple signaling pathways in cardiovascular diseases -therapeutic target hsa-mir-155 Rheumatoid Arthritis 29105307 Hopefully the information obtained will benefit the development of novel therapeutic strategies -therapeutic target hsa-mir-130a Cardiac Fibrosis 29114000 "MicroRNA-130a, a Potential Antifibrotic Target in Cardiac Fibrosis." -therapeutic target hsa-mir-145 "Carcinoma, Hepatocellular" 29156696 The interaction between pSmad3C/3L and microRNA-145/21 regulates HCC progression and the switch of pSmad3C/3L may serve as an important target for HCC therapy -therapeutic target hsa-mir-29b Glioblastoma 29176935 miR-29b may serve as a putative therapeutic molecule when its expression is restored using a nanoparticle delivery system in GBM -therapeutic target hsa-mir-20a Breast Neoplasms 29179464 Therapy directed at uPAR-induced miR-17/20a is a potential option for breast cancer and TNBC -therapeutic target hsa-mir-124 Glioblastoma 29185191 MicroRNAs (miRs) are potential therapeutic targets in glioblastoma multiforme (GBM) -therapeutic target hsa-mir-21 Keloid 29190966 "inhibition of microRNA-21 induces mitochondrial-mediated apoptosis in keloid fibroblasts, proposing microRNA-21 as a potential therapeutic target in keloid fibroblasts" -therapeutic target hsa-mir-126 Pancreatic Adenocarcinoma 29200874 The therapeutic system co-expressing miR-126 and miR-34a mediated by oncolytic adenovirus is a promising system for PAC target therapy -therapeutic target hsa-mir-34a Pancreatic Adenocarcinoma 29200874 The therapeutic system co-expressing miR-126 and miR-34a mediated by oncolytic adenovirus is a promising system for PAC target therapy -therapeutic target hsa-mir-150 Chronic Obstructive Pulmonary Disease 29205062 Restoration of miR-150 expression may represent a potential therapeutic strategy for CS-related COPD -therapeutic target hsa-mir-100 Atherosclerosis 29208678 "Our findings of miR-100 as a potential protective anti-athero-miR suggest that the therapeutic replacement of this microRNA could be a potential strategy for the treatment of chronic inflammatory diseases, such as atherosclerosis, in the future" -therapeutic target hsa-mir-21 Atherosclerosis 29228671 "our results demonstrated that metformin improved IRSM by inhibiting miR-21 expression, and that miR-21 may be one of the therapeutic targets for IR" -therapeutic target hsa-let-7a Prostate Neoplasms 29236328 the therapeutic potential of Let-7a as an antitumor and antimetastatic manager in prostate cancer and CCR7 may be regarded as a therapeutic target for the prostate cancer treatment -therapeutic target hsa-mir-34a Multiple Myeloma 29263373 Evidence of novel miR-34a-based therapeutic approaches for multiple myeloma treatment -therapeutic target hsa-mir-1 Myocardial Infarction 29269324 Delivery of microRNA-1 inhibitor by dendrimer-based nanovector: An early targeting therapy for myocardial infarction in mice -therapeutic target hsa-mir-204 "Adenocarcinoma, Lung" 29281186 "Clinically, the miR-204/JAK2/STAT3 signaling pathway is a putative therapeutic target in lung adenocarcinoma" -therapeutic target hsa-mir-155 Neoplasms [unspecific] 29282605 miR-155 in cancer drug resistance and as target for miRNA-based therapeutics -therapeutic target hsa-mir-34a Heart Diseases [unspecific] 29302057 "inhibition of miR-34a activity has differential effects depending on the cell type, thereby warranting the need to eliminate off-target effects when introducing miR-based therapy" -therapeutic target hsa-mir-205 "Carcinoma, Thyroid, Anaplastic" 29317480 This may open avenues to exploit miR-205 as an alternative cancer therapeutic strategy in the future -therapeutic target hsa-mir-19a Cervical Neoplasms 29332345 "Overall, inhibiting miR-19a significantly improves the sensitivity of SiHa cells to radiotherapy, which could lead to new methods for the treatment of cervical cancer" -therapeutic target hsa-let-7 Breast Neoplasms 29336465 the findings identified a biochemical and functional link between Let-7 and endocrine therapy in breast CSCs -therapeutic target hsa-mir-21 Glioblastoma 29340361 DP-Cur is an efficient carrier of miR21ASO and the combined delivery of miR21ASO and curcumin may be useful in the development of combination therapy for glioblastoma -therapeutic target hsa-mir-221 "Carcinoma, Thyroid" 29351231 These ceRNAs are critical in revealing the secrets behind thyroid cancer progression and may serve as future therapeutic biomarkers -therapeutic target hsa-mir-222 "Carcinoma, Thyroid" 29351231 These ceRNAs are critical in revealing the secrets behind thyroid cancer progression and may serve as future therapeutic biomarkers -therapeutic target hsa-mir-375 "Carcinoma, Thyroid" 29351231 These ceRNAs are critical in revealing the secrets behind thyroid cancer progression and may serve as future therapeutic biomarkers -therapeutic target hsa-mir-155 Arthritis 29354135 "we review the evidence for the pathogenic role of miR-155 in driving aberrant activation of the immune system in rheumatoid arthritis, and its potential as a disease biomarker and therapeutic target" -therapeutic target hsa-mir-16 Short Bowel Syndrome 29364022 Modulation of these pathways may represent a new therapeutic option for the management of short bowel syndrome -therapeutic target hsa-mir-5338 Prostate Disease 29382326 Study on the inhibition of Mfn1 by plant-derived miR5338 mediating the treatment of BPH with rape bee pollen. -therapeutic target hsa-mir-155 Polycystic Ovarian Syndrome 29385860 Serum miRNAs in women affected by hyperandrogenic polycystic ovary syndrome: the potential role of miR-155 as a biomarker for monitoring the estroprogestinic treatment. -therapeutic target hsa-mir-200a Colorectal Carcinoma 29388209 The miR200 family has potential for both prognostic and therapeutic management of CRC. -therapeutic target hsa-mir-200c Colorectal Carcinoma 29388209 The miR201 family has potential for both prognostic and therapeutic management of CRC. -therapeutic target hsa-mir-19a "Carcinoma, Hepatocellular" 29393488 miR?19a may have potential as a novel molecular marker for HCC and Pter may be a promising clinical target with the potential to be developed as a HCC therapy -therapeutic target hsa-mir-15a Breast Neoplasms 29394261 modulatingspecific miRNAs may serve as a therapeutic approach for the treatment of breast cancer -therapeutic target hsa-let-7b Intestinal Barrier Dysfunction 29402773 Let-7b was identified as a novel diagnosis biomarker or a potential treatment target for preventing intestinal barrier dysfunction -therapeutic target hsa-mir-221 Parkinson Disease 29405726 miR-221 may serve as a potential therapeutic target for Parkinson's disease treatment -therapeutic target hsa-mir-155 Liver Injury 29420849 maintaining miR-155 expression in inflammatory cells might be a potential strategy to modulate liver injury -therapeutic target hsa-mir-145 Hypertension 29434681 miR-145 is a potential target for the treatment of hypertension -therapeutic target hsa-mir-1268a Neoplasms [unspecific] 29435930 "Quantum Language of MicroRNA: Application for New Cancer Therapeutic Targets(the top 5 of high DNS were in rmiRNAs, rmiR-4466 in 5¡äETS, rmiR-3656 in 28S, rmiR-1268a and rmiR-1268b in 3¡äETS, and rmiR-6729)" -therapeutic target hsa-mir-1268b Neoplasms [unspecific] 29435930 "Quantum Language of MicroRNA: Application for New Cancer Therapeutic Targets(the top 5 of high DNS were in rmiRNAs, rmiR-4466 in 5¡äETS, rmiR-3656 in 28S, rmiR-1268a and rmiR-1268b in 3¡äETS, and rmiR-6729)" -therapeutic target hsa-mir-3656 Neoplasms [unspecific] 29435930 "Quantum Language of MicroRNA: Application for New Cancer Therapeutic Targets(the top 5 of high DNS were in rmiRNAs, rmiR-4466 in 5¡äETS, rmiR-3656 in 28S, rmiR-1268a and rmiR-1268b in 3¡äETS, and rmiR-6729)" -therapeutic target hsa-mir-4466 Neoplasms [unspecific] 29435930 "Quantum Language of MicroRNA: Application for New Cancer Therapeutic Targets(the top 5 of high DNS were in rmiRNAs, rmiR-4466 in 5¡äETS, rmiR-3656 in 28S, rmiR-1268a and rmiR-1268b in 3¡äETS, and rmiR-6729)" -therapeutic target hsa-mir-6729 Neoplasms [unspecific] 29435930 "Quantum Language of MicroRNA: Application for New Cancer Therapeutic Targets(the top 5 of high DNS were in rmiRNAs, rmiR-4466 in 5¡äETS, rmiR-3656 in 28S, rmiR-1268a and rmiR-1268b in 3¡äETS, and rmiR-6729)" -therapeutic target hsa-mir-10a Atherosclerosis 29459264 EC miR-10a induction by RAR¦Á/RXR¦Á-specific agonists is a potential hemodynamics-based strategy for atherosclerosis treatment -therapeutic target hsa-mir-17 "Carcinoma, Hepatocellular" 29464015 "Hence, anti-miR-17 is an effective therapy for MYC-driven HCC" -therapeutic target hsa-mir-22 Heart Failure 29486470 "Our findings demonstrate that miR-22 accelerates cardiac fibrosis through the miR-22-Cav3-PKC¦Å pathway, which, therefore, may represent a new therapeutic target for treatment of excessive fibrosis-associated cardiac diseases" -therapeutic target hsa-mir-146a Ischemia-Reperfusion Injury 29505740 our findings demonstrate that the elevation of miR-146a may be one of the compensatory responses after the cerebral I/R injury and suggest miR-146a as a potential therapeutic target for cerebral I/R injury -therapeutic target hsa-mir-134 Diabetic Nephropathy 29532746 MiR-150 and miR-134 may be essential microRNAs in the treatment of MSCs for DN -therapeutic target hsa-mir-150 Diabetic Nephropathy 29532746 MiR-150 and miR-134 may be essential microRNAs in the treatment of MSCs for DN -therapeutic target hsa-mir-155 "Carcinoma, Renal Cell, Clear-Cell" 29534467 Our results further support a role for miR-155 as a promising cancer classifier and potentially as a therapeutic target in ccRCC that merits further investigation -therapeutic target hsa-mir-192 "Carcinoma, Bladder" 29536411 miR-192-5p might serve as a promising target in bladder cancer diagnosis and therapy -therapeutic target hsa-mir-125b Hepatitis C Virus Infection 29541414 This study elucidates a novel pathway for miR-125b in the pathogenesis of chronic HCV infection and suggests it as a possible target for treating HCV infection -therapeutic target hsa-let-7d Alzheimer Disease 29543360 The potential functions of these miRNAs as diagnostic and therapeutic targets of the AD were revealed by this study -therapeutic target hsa-let-7g Alzheimer Disease 29543360 The potential functions of these miRNAs as diagnostic and therapeutic targets of the AD were revealed by this study -therapeutic target hsa-mir-101 Alzheimer Disease 29543360 The potential functions of these miRNAs as diagnostic and therapeutic targets of the AD were revealed by this study -therapeutic target hsa-mir-125b Alzheimer Disease 29543360 The potential functions of these miRNAs as diagnostic and therapeutic targets of the AD were revealed by this study -therapeutic target hsa-mir-155 Alzheimer Disease 29543360 The potential functions of these miRNAs as diagnostic and therapeutic targets of the AD were revealed by this study -therapeutic target hsa-mir-15b Alzheimer Disease 29543360 The potential functions of these miRNAs as diagnostic and therapeutic targets of the AD were revealed by this study -therapeutic target hsa-mir-191 Alzheimer Disease 29543360 The potential functions of these miRNAs as diagnostic and therapeutic targets of the AD were revealed by this study -therapeutic target hsa-mir-26b Alzheimer Disease 29543360 The potential functions of these miRNAs as diagnostic and therapeutic targets of the AD were revealed by this study -therapeutic target hsa-mir-29b Alzheimer Disease 29543360 The potential functions of these miRNAs as diagnostic and therapeutic targets of the AD were revealed by this study -therapeutic target hsa-mir-342 Alzheimer Disease 29543360 The potential functions of these miRNAs as diagnostic and therapeutic targets of the AD were revealed by this study -therapeutic target hsa-mir-34a Alzheimer Disease 29543360 The potential functions of these miRNAs as diagnostic and therapeutic targets of the AD were revealed by this study -therapeutic target hsa-mir-9 Alzheimer Disease 29543360 The potential functions of these miRNAs as diagnostic and therapeutic targets of the AD were revealed by this study -therapeutic target hsa-mir-7 Colorectal Carcinoma 29549306 therapeutic targeting of the c-Myb/circHIPK3/miR-7 axis may be a promising treatment approach for CRC patients -therapeutic target hsa-mir-21 Breast Neoplasms 29567152 chemically modified miRNA-21 inhibitor based on gold nanoparticles would be as a promising diagnostic and therapeutic platform for breast cancer clinically -therapeutic target hsa-mir-21 "Squamous Cell Carcinoma, Esophageal" 29568234 MiR-21 is a potential novel target for developing specific treatment interventions in ESCC in future -therapeutic target hsa-mir-186 Melanoma 29578151 "miR-186 exhibit an inhibitory effect on CMM cell proliferation, migration, and invasion; thus, may serve as a potential therapeutic target for human CMM intervention" -therapeutic target hsa-mir-200c Chronic Hepatitis B 29593314 an HBV-pSTAT3-SALL4-miR-200c axis regulates PD-L1. Therapeutic strategies to influence this axis might reverse virus-induced immune exhaustion -therapeutic target hsa-mir-124 Neoplasms [unspecific] 29602831 "This novel ncRNA bioengineering platform can be easily adapted to produce various ncRNA molecules, and biologic ncRNAs hold the promise as new cancer therapeutics" -therapeutic target hsa-mir-34a Neoplasms [unspecific] 29602831 "This novel ncRNA bioengineering platform can be easily adapted to produce various ncRNA molecules, and biologic ncRNAs hold the promise as new cancer therapeutics" -therapeutic target hsa-mir-21 Inflammation 29620442 It may provide a novel therapeutic strategy to regulate the odontoblast differentiation of DPSCs -therapeutic target hsa-mir-21 Endometriosis 29625267 Identification of small-molecule ligands that bind to MiR-21 as potential therapeutics for endometriosis by screening ZINC database and in-vitro assays. -therapeutic target hsa-mir-143 Endometrial Neoplasms 29661100 these miRNAs are potential candidates for the diagnosis of endometrial cancer and therapeutic targets -therapeutic target hsa-mir-145 Endometrial Neoplasms 29661100 these miRNAs are potential candidates for the diagnosis of endometrial cancer and therapeutic targets -therapeutic target hsa-mir-378 Bone Disease [unspecific] 29686962 "miR378 was an ideal target to osteogenesis-angiogenesis coupling for bone regeneration, which provides a potential tool for the gene therapy of bone regeneration." -therapeutic target hsa-mir-139 Ovarian Neoplasms 29719173 miR-139-5p overexpression might be a future therapeutic strategy for OC. -therapeutic target hsa-mir-145 Urinary Bladder Cancer 29723992 "MicroRNAs in Smoking-Related Carcinogenesis: Biomarkers, Functions, and Therapy." -therapeutic target hsa-mir-224 "Carcinoma, Lung, Non-Small-Cell" 29723992 "MicroRNAs in Smoking-Related Carcinogenesis: Biomarkers, Functions, and Therapy." -therapeutic target hsa-mir-21 Seizures 29751355 The miR-21-5p/PTEN/mTOR axis may be a potential target for preventing and treating seizures and epileptic damage -therapeutic target hsa-mir-204 "Leukemia, Myeloid, Acute" 29764561 MiR-204 acts as a potential therapeutic target in acute myeloid leukemia by increasing BIRC6-mediated apoptosis. -therapeutic target hsa-mir-107 Burns 29802017 "Expression of junctional proteins such as claudin-1, loricrin, filaggrin, ZO-1, and ZO-2 were significantly upregulated following TLN¦Ê/anti-miR-107 treatment" -therapeutic target hsa-mir-145 "Carcinoma, Hepatocellular" 29805683 "certain miRNAs (including miR-96, miR-145 and miR-183) and mRNAs may be therapeutic targets of ribavirin in hepatocellular carcinoma." -therapeutic target hsa-mir-183 "Carcinoma, Hepatocellular" 29805683 "certain miRNAs (including miR-96, miR-145 and miR-183) and mRNAs may be therapeutic targets of ribavirin in hepatocellular carcinoma." -therapeutic target hsa-mir-96 "Carcinoma, Hepatocellular" 29805683 "certain miRNAs (including miR-96, miR-145 and miR-183) and mRNAs may be therapeutic targets of ribavirin in hepatocellular carcinoma." -therapeutic target hsa-mir-106a Prostate Neoplasms 29845714 "Our research provides the first report of miR-106a and LITAF in prostate cancer radiation resistance and high-grade disease, and presents a viable therapeutic strategy that may ultimately improve patient outcomes" -therapeutic target hsa-mir-543 Periodontitis 29851072 miR-543 may be a potential therapy for bone loss in periodontitis -therapeutic target hsa-mir-145 Prostate Neoplasms 29858716 Treating metastatic prostate cancer with microRNA-145. -therapeutic target hsa-mir-335 Sepsis 29866515 upregulation of miR-335-5p is therapeutic strategy for sepsis -therapeutic target hsa-mir-1297 Melanoma 29873263 seed-targeted anti-miR-1297 might serve as a new tactic for miR-1297-based therapies -therapeutic target hsa-mir-9 Gastric Neoplasms 29879907 Targeting miR-9 in gastric cancer cells using locked nucleic acid oligonucleotides. -therapeutic target hsa-mir-143 Neoplasms [unspecific] 29929447 Hsa-miR-143-3p and hsa-miR-193b-3p were found to be up-regulated by the use of different non-viral vectors and can thus serve as potential targets of non-viral cancer gene therapy -therapeutic target hsa-mir-193b Neoplasms [unspecific] 29929447 Hsa-miR-143-3p and hsa-miR-193b-3p were found to be up-regulated by the use of different non-viral vectors and can thus serve as potential targets of non-viral cancer gene therapy -therapeutic target hsa-mir-146a Autism Spectrum Disorder 29951184 miR-146a may be new therapeutic targets and strategies -therapeutic target hsa-mir-214 Human Papilloma Virus Infection 29952653 MiR-214-3p can possibly serve as a valuable biomarker and a therapeutic target for SNIP -therapeutic target hsa-mir-29a Liver Fibrosis 29954104 "This review focuses on the evolving view of the molecular mechanisms by which HSC activation by miR-29a signaling may moderate the profibrogenic phenotype of these cells, thus supporting the use of miR-29a agonists as a potential therapy for treating liver fibrosis in the future" -therapeutic target hsa-mir-21 Hypertension 29973661 The potential role of miR-21 as a new target for predicting and treating hypertension is also explored -therapeutic target hsa-mir-21 "Carcinoma, Breast" 29981261 Dynamic microRNA activity identifies therapeutic targets in trastuzumab-resistant HER2+ breast cancer. -therapeutic target hsa-mir-17 Multiple Myeloma 29997223 "Therapeutic vulnerability of multiple myeloma to MIR17PTi, a first-in-class inhibitor of pri-miR-17-92." -therapeutic target hsa-mir-18 Multiple Myeloma 29997223 "Therapeutic vulnerability of multiple myeloma to MIR17PTi, a first-in-class inhibitor of pri-miR-17-92." -therapeutic target hsa-mir-19a Multiple Myeloma 29997223 "Therapeutic vulnerability of multiple myeloma to MIR17PTi, a first-in-class inhibitor of pri-miR-17-92." -therapeutic target hsa-mir-19b-1 Multiple Myeloma 29997223 "Therapeutic vulnerability of multiple myeloma to MIR17PTi, a first-in-class inhibitor of pri-miR-17-92." -therapeutic target hsa-mir-20a Multiple Myeloma 29997223 "Therapeutic vulnerability of multiple myeloma to MIR17PTi, a first-in-class inhibitor of pri-miR-17-92." -therapeutic target hsa-mir-92-1 Multiple Myeloma 29997223 "Therapeutic vulnerability of multiple myeloma to MIR17PTi, a first-in-class inhibitor of pri-miR-17-92." -therapeutic target hsa-mir-155 Mesial Temporal Lobe Epilepsy 30006293 regulation of the miR-155/TNF-¦Á axis may be a new therapeutic target for TLE -therapeutic target hsa-mir-135a Glioma 30015885 "miR?135A/B, and the target FOXO1, may be potential therapy targets for glioma treatment" -therapeutic target hsa-mir-135b Glioma 30015885 "miR?135A/B, and the target FOXO1, may be potential therapy targets for glioma treatment" -therapeutic target hsa-mir-338 Bone Disease [unspecific] 30029590 "new miRNAs like MIR-338 and MIR-376A were identified, which may serve as potential therapeutic targets for the effective treatment of cerebral ischemic injury" -therapeutic target hsa-mir-367a Bone Disease [unspecific] 30029590 "new miRNAs like MIR-338 and MIR-376A were identified, which may serve as potential therapeutic targets for the effective treatment of cerebral ischemic injury" -therapeutic target hsa-mir-122 Hepatitis C Virus Infection 30038017 "MicroRNA-122 (miR-122), a target of current phase II anti-HCV drugs, is known to protect HCV transcripts against XRNs" -therapeutic target hsa-mir-34a "Carcinoma, Breast, Triple Negative" 30072748 MicroRNA in diagnosis and therapy monitoring of early-stage triple-negative breast cancer. -therapeutic target hsa-mir-1290 Colon Neoplasms 30073936 "particularly hsa-miR-424-5p, hsa-miR-96-5p, hsa-miR-1290, hsa-miR-224, hsa-miR-133a and has-miR-363-3p present possible targets for colon cancer" -therapeutic target hsa-mir-133a Colon Neoplasms 30073936 "particularly hsa-miR-424-5p, hsa-miR-96-5p, hsa-miR-1290, hsa-miR-224, hsa-miR-133a and has-miR-363-3p present possible targets for colon cancer" -therapeutic target hsa-mir-224 Colon Neoplasms 30073936 "particularly hsa-miR-424-5p, hsa-miR-96-5p, hsa-miR-1290, hsa-miR-224, hsa-miR-133a and has-miR-363-3p present possible targets for colon cancer" -therapeutic target hsa-mir-363 Colon Neoplasms 30073936 "particularly hsa-miR-424-5p, hsa-miR-96-5p, hsa-miR-1290, hsa-miR-224, hsa-miR-133a and has-miR-363-3p present possible targets for colon cancer" -therapeutic target hsa-mir-424 Colon Neoplasms 30073936 "particularly hsa-miR-424-5p, hsa-miR-96-5p, hsa-miR-1290, hsa-miR-224, hsa-miR-133a and has-miR-363-3p present possible targets for colon cancer" -therapeutic target hsa-mir-96 Colon Neoplasms 30073936 "particularly hsa-miR-424-5p, hsa-miR-96-5p, hsa-miR-1290, hsa-miR-224, hsa-miR-133a and has-miR-363-3p present possible targets for colon cancer" -therapeutic target hsa-mir-26a "Carcinoma, Hepatocellular" 30076741 Lower expression of tumor microRNA-26a is associated with higher recurrence in patients with hepatocellular carcinoma undergoing surgical treatment. -therapeutic target hsa-mir-326 Autoimmune Diseases [unspecific] 30078204 "The MicroRNA-326: Autoimmune diseases, diagnostic biomarker, and therapeutic target." -therapeutic target hsa-mir-141 "Carcinoma, Hepatocellular" 30083268 Tumor-suppressing miR-141 gene complex-loaded tissue-adhesive glue for the locoregional treatment of hepatocellular carcinoma. -therapeutic target hsa-mir-33 Atherosclerosis 30092598 miR-33 represents a novel target for the treatment of atherosclerosis -therapeutic target hsa-mir-187 Gastric Neoplasms 30112051 miR-187 may be a potential biomarker and therapeutic target in GC -therapeutic target hsa-mir-143 Neoplasms [unspecific] 30150287 Our findings will encourage the development of new strategies targeting miR-143 in both cancer cells and T cells -therapeutic target hsa-mir-21 Primary Aldosteronism 30153065 miR-21 supplementation may be a novel therapeutic approach to abolish or mitigate excess aldosterone-mediated cardiovascular deleterious effects in primary aldosteronism -therapeutic target hsa-mir-30a Neoplasms [unspecific] 30158978 MiR-30a: A Novel Biomarker and Potential Therapeutic Target for Cancer. -therapeutic target hsa-mir-10a "Carcinoma, Breast" 30160115 Anti-breast-Cancer Activity Exerted by ¦Â-Sitosterol-d-glucoside from Sweet Potato via Upregulation of MicroRNA-10a and via the PI3K-Akt Signaling Pathway. -therapeutic target hsa-mir-223 Wound Healing 30171089 Targeting miR-223 in neutrophils enhances the?clearance of Staphylococcus aureus in infected?wounds. -therapeutic target hsa-mir-636 Hepatitis C Virus Infection 30174796 miR-636 might be one of the essential targetable molecules in HCV patients who undergo DAA therapy and still suffer from a sustained HCV infection -therapeutic target hsa-mir-383 Heart Failure 30206318 Multipoint targeting of TGF-¦Â/Wnt transactivation circuit with microRNA 384-5p for cardiac fibrosis. -therapeutic target hsa-mir-126 Vascular Injuries 30213595 Dicer promotes endothelial recovery and limits lesion formation after vascular injury through miR-126-5p. -therapeutic target hsa-mir-210 Cholangiocarcinoma 30214622 Cholangiocarcinoma therapy with nanoparticles that combine downregulation of MicroRNA-210 with inhibition of cancer cell invasiveness. -therapeutic target hsa-mir-150 Rheumatoid Arthritis 30224512 Therapeutic Potential of Mesenchymal Cell-Derived miRNA-150-5p-Expressing Exosomes in Rheumatoid Arthritis Mediated by the Modulation of MMP14 and VEGF. -therapeutic target hsa-mir-423 "Adenocarcinoma, Lung" 30224667 MiR-423-5p has the potential to be a marker of BM and/or a therapeutic target in LAD -therapeutic target hsa-mir-126 "Carcinoma, Hepatocellular" 30268144 Targeting miR-494-3p and miR-126-3p may provide effective and promising approaches to suppress invasion and metastasis of HCC -therapeutic target hsa-mir-494 "Carcinoma, Hepatocellular" 30268144 Targeting miR-494-3p and miR-126-3p may provide effective and promising approaches to suppress invasion and metastasis of HCC -therapeutic target hsa-mir-17 Rectal Neoplasms 30277504 Expression profile of miR-17/92 cluster is predictive of treatment response in rectal cancer. -therapeutic target hsa-mir-18 Rectal Neoplasms 30277504 Expression profile of miR-17/92 cluster is predictive of treatment response in rectal cancer. -therapeutic target hsa-mir-19a Rectal Neoplasms 30277504 Expression profile of miR-17/92 cluster is predictive of treatment response in rectal cancer. -therapeutic target hsa-mir-19b-1 Rectal Neoplasms 30277504 Expression profile of miR-17/92 cluster is predictive of treatment response in rectal cancer. -therapeutic target hsa-mir-20a Rectal Neoplasms 30277504 Expression profile of miR-17/92 cluster is predictive of treatment response in rectal cancer. -therapeutic target hsa-mir-92-1 Rectal Neoplasms 30277504 Expression profile of miR-17/92 cluster is predictive of treatment response in rectal cancer. -therapeutic target hsa-mir-425 "Leukemia, Myeloid, Acute" 30285885 MiR-425 expression profiling in acute myeloid leukemia might guide the treatment choice between allogeneic transplantation and chemotherapy. -therapeutic target hsa-mir-221 "Fatty Liver, Non-Alcoholic" 30316865 Targeting hepatic miR-221/222 for therapeutic intervention of nonalcoholic steatohepatitis in mice. -therapeutic target hsa-mir-222 "Fatty Liver, Non-Alcoholic" 30316865 Targeting hepatic miR-221/222 for therapeutic intervention of nonalcoholic steatohepatitis in mice. -therapeutic target hsa-mir-155 Neoplasms [unspecific] 30319757 "a DNA nanotube structure that carries functional DNA segments (single-stranded, duplex and hairpin forms) was designed and synthesized to capture two well-known overexpressed miRNAs, miR-21 and miR-155" -therapeutic target hsa-mir-21 Neoplasms [unspecific] 30319757 "a DNA nanotube structure that carries functional DNA segments (single-stranded, duplex and hairpin forms) was designed and synthesized to capture two well-known overexpressed miRNAs, miR-21 and miR-155" -therapeutic target hsa-mir-20a "Leukemia, T-Cell" 30336537 miR-20a may act as a tumor suppressor in CD4+ T cells and also has a potential therapeutic in these kinds of cancers -therapeutic target hsa-mir-34c "Carcinoma, Lung, Non-Small-Cell" 30340138 the GL21.T/miR-34c chimera exerts dual inhibition of AXL at functional and transcriptional levels and represents a novel therapeutic tool for the treatment of NSCLC -therapeutic target hsa-mir-200b "Carcinoma, Breast" 30342533 The miR-200b presents a great potential for the future advancements in the diagnostic/prognostic and therapeutic approach of TNBC -therapeutic target hsa-mir-647 "Carcinoma, Lung, Non-Small-Cell" 30349310 MicroRNA-647 promotes the therapeutic effectiveness of argon-helium cryoablation and inhibits cell proliferation through targeting TRAF2 via the NF-¦ÊB signaling pathway in non-small cell lung cancer. -therapeutic target hsa-mir-33b Atherosclerosis 30354203 miR-33b is a promising target for treating atherosclerosis -therapeutic target hsa-mir-1247 Prostate Neoplasms 30378132 our data highlight miR-1247 as a potential target for molecular therapies aimed to block the progression and diffusion of PCa -therapeutic target hsa-mir-20b Tuberculosis 30378171 miR-20b-5p and exosomes as the potential therapeutic targets of TB -transcription factor target hsa-mir-451 "Leukemia, Myeloid, Chronic" 27825294 Downregulation of miR-451 in Tunisian chronic myeloid leukemia patients: potential implication in imatinib resistance. -transcription factor target hsa-mir-20a Retinoblastoma 17135249 "Altogether, these results suggest that the autoregulation between E2F1-3 and miR-20a is important for preventing an abnormal accumulation of E2F1-3 and may play a role in the regulation of cellular proliferation and apoptosis." -transcription factor target hsa-mir-21 Multiple Myeloma 17496199 Ectopically raising miR-21 expression in myeloma cells in the absence of IL-6 significantly reduced their apoptosis levels. These data provide strong evidence that miR-21 induction contributes to the oncogenic potential of Stat3. -transcription factor target hsa-mir-34a Neoplasms [unspecific] 17656095 "Taken together, the data suggest the miRNA34s might be key effectors of p53 tumor-suppressor function, and their inactivation might contribute to certain cancers." -transcription factor target hsa-mir-34b Neoplasms [unspecific] 17656095 "Taken together, the data suggest the miRNA34s might be key effectors of p53 tumor-suppressor function, and their inactivation might contribute to certain cancers." -transcription factor target hsa-mir-34c Neoplasms [unspecific] 17656095 "Taken together, the data suggest the miRNA34s might be key effectors of p53 tumor-suppressor function, and their inactivation might contribute to certain cancers." -transcription factor target hsa-mir-34b "Carcinoma, Ovarian" 17823410 "Importantly, miR-34b and miR-34c cooperate in suppressing proliferation and soft-agar colony formation of neoplastic epithelial ovarian cells, in agreement with the partially overlapping spectrum of their predicted targets." -transcription factor target hsa-mir-34c "Carcinoma, Ovarian" 17823410 "Importantly, miR-34b and miR-34c cooperate in suppressing proliferation and soft-agar colony formation of neoplastic epithelial ovarian cells, in agreement with the partially overlapping spectrum of their predicted targets." -transcription factor target hsa-mir-106a Neuroblastoma 17943719 The miR-17-92 polycistron also acts as an oncogene in haematopoietic progenitor cells. We show here that miR-221 is also induced by MYCN in neuroblastoma. -transcription factor target hsa-mir-17 Neuroblastoma 17943719 The miR-17-92 polycistron also acts as an oncogene in haematopoietic progenitor cells. We show here that miR-221 is also induced by MYCN in neuroblastoma. -transcription factor target hsa-mir-18 Neuroblastoma 17943719 The miR-17-92 polycistron also acts as an oncogene in haematopoietic progenitor cells. We show here that miR-221 is also induced by MYCN in neuroblastoma. -transcription factor target hsa-mir-19a Neuroblastoma 17943719 The miR-17-92 polycistron also acts as an oncogene in haematopoietic progenitor cells. We show here that miR-221 is also induced by MYCN in neuroblastoma. -transcription factor target hsa-mir-19b-1 Neuroblastoma 17943719 The miR-17-92 polycistron also acts as an oncogene in haematopoietic progenitor cells. We show here that miR-221 is also induced by MYCN in neuroblastoma. -transcription factor target hsa-mir-20a Neuroblastoma 17943719 The miR-17-92 polycistron also acts as an oncogene in haematopoietic progenitor cells. We show here that miR-221 is also induced by MYCN in neuroblastoma. -transcription factor target hsa-mir-221 Neuroblastoma 17943719 The miR-17-92 polycistron also acts as an oncogene in haematopoietic progenitor cells. We show here that miR-221 is also induced by MYCN in neuroblastoma. -transcription factor target hsa-mir-92-1 Neuroblastoma 17943719 The miR-17-92 polycistron also acts as an oncogene in haematopoietic progenitor cells. We show here that miR-221 is also induced by MYCN in neuroblastoma. -transcription factor target hsa-mir-125b Prostate Neoplasms 18056640 "Our results suggest that miR-125b acts as an oncogene, contributing to the pathogenesis of CaP." -transcription factor target hsa-mir-184 Autism Spectrum Disorder 18203756 The restricted release of MeCP2 from the paternal allele results in paternal allele-specific expression of miR-184. Our finding provides a clue to the link between the microRNA and DNA methylation pathways. -transcription factor target hsa-mir-21 Neoplasms [unspecific] 18384814 "Since exogenous miR-21 expression moderately induced endogenous miR-21, an evolutionarily conserved double-negative feedback regulation would be operating as a mechanism to sustain miR-21 expression." -transcription factor target hsa-mir-23a "Carcinoma, Hepatocellular" 18508316 We also explore that miR-23a approximately 27a approximately 24 can function as an antiapoptotic and proliferation-promoting factor in liver cancer cells. -transcription factor target hsa-mir-24 "Carcinoma, Hepatocellular" 18508316 We also explore that miR-23a approximately 27a approximately 24 can function as an antiapoptotic and proliferation-promoting factor in liver cancer cells. -transcription factor target hsa-mir-27a "Carcinoma, Hepatocellular" 18508316 We also explore that miR-23a approximately 27a approximately 24 can function as an antiapoptotic and proliferation-promoting factor in liver cancer cells. -transcription factor target hsa-mir-146a Leukemia 18568019 "In leukaemic cell lines PLZF overexpression downmodulated miR-146a and upregulated CXCR4 protein, whereas PLZF knockdown induced the opposite effects." -transcription factor target hsa-mir-34a "Leukemia, Lymphocytic, Chronic, B-Cell" 18818704 17p13/TP53 deletion in B-CLL patients is associated with microRNA-34a downregulation. -transcription factor target hsa-mir-141 Neoplasms [unspecific] 18829540 These findings establish a double-negative feedback loop controlling ZEB1-SIP1 and miR-200 family expression that regulates cellular phenotype and has direct relevance to the role of these factors in tumor progression. -transcription factor target hsa-mir-200a Neoplasms [unspecific] 18829540 These findings establish a double-negative feedback loop controlling ZEB1-SIP1 and miR-200 family expression that regulates cellular phenotype and has direct relevance to the role of these factors in tumor progression. -transcription factor target hsa-mir-200b Neoplasms [unspecific] 18829540 These findings establish a double-negative feedback loop controlling ZEB1-SIP1 and miR-200 family expression that regulates cellular phenotype and has direct relevance to the role of these factors in tumor progression. -transcription factor target hsa-mir-200c Neoplasms [unspecific] 18829540 These findings establish a double-negative feedback loop controlling ZEB1-SIP1 and miR-200 family expression that regulates cellular phenotype and has direct relevance to the role of these factors in tumor progression. -transcription factor target hsa-mir-429 Neoplasms [unspecific] 18829540 These findings establish a double-negative feedback loop controlling ZEB1-SIP1 and miR-200 family expression that regulates cellular phenotype and has direct relevance to the role of these factors in tumor progression. -transcription factor target hsa-mir-7 Breast Neoplasms 18922890 "Finally, we show that miR-7 introduction inhibits the motility, invasiveness, anchorage-independent growth, and tumorigenic potential of highly invasive breast cancer cells." -transcription factor target hsa-mir-155 Inflammation 18940871 "Finally, we demonstrate that LMP1-mediated activation of miR-155 in an EBV-negative background correlates with reduction of protein PU.1, which is a possible miR target." -transcription factor target hsa-mir-146a Neoplasms [unspecific] 19021527 "In the present article, we review the evidence for a role of miR-146a in innate immunity and cancer and assess whether changes in miR-146a might link these two biological responses." -transcription factor target hsa-mir-17 Neoplasms [unspecific] 19066217 "Using the concept and model prediction of a ""cancer zone,"" the oncogenic and tumor suppressor properties of miR-17-92 is demonstrated to parallel the same properties of E2F and Myc." -transcription factor target hsa-mir-18 Neoplasms [unspecific] 19066217 "Using the concept and model prediction of a ""cancer zone,"" the oncogenic and tumor suppressor properties of miR-17-92 is demonstrated to parallel the same properties of E2F and Myc." -transcription factor target hsa-mir-19a Neoplasms [unspecific] 19066217 "Using the concept and model prediction of a ""cancer zone,"" the oncogenic and tumor suppressor properties of miR-17-92 is demonstrated to parallel the same properties of E2F and Myc." -transcription factor target hsa-mir-19b-1 Neoplasms [unspecific] 19066217 "Using the concept and model prediction of a ""cancer zone,"" the oncogenic and tumor suppressor properties of miR-17-92 is demonstrated to parallel the same properties of E2F and Myc." -transcription factor target hsa-mir-20a Neoplasms [unspecific] 19066217 "Using the concept and model prediction of a ""cancer zone,"" the oncogenic and tumor suppressor properties of miR-17-92 is demonstrated to parallel the same properties of E2F and Myc." -transcription factor target hsa-mir-92-1 Neoplasms [unspecific] 19066217 "Using the concept and model prediction of a ""cancer zone,"" the oncogenic and tumor suppressor properties of miR-17-92 is demonstrated to parallel the same properties of E2F and Myc." -transcription factor target hsa-mir-192 Colon Neoplasms 19074875 "Hence, miR-192 and miR-215 can act as effectors as well as regulators of p53; they seem to suppress cancerogenesis through p21 accumulation and cell cycle arrest." -transcription factor target hsa-mir-215 Colon Neoplasms 19074875 "Hence, miR-192 and miR-215 can act as effectors as well as regulators of p53; they seem to suppress cancerogenesis through p21 accumulation and cell cycle arrest." -transcription factor target hsa-mir-34a Neoplasms [unspecific] 19074875 "Accordingly, the tumor suppressor p53 up-regulates miR-34a, a microRNA that contributes to apoptosis and acute senescence. " -transcription factor target hsa-mir-1 Cardiomegaly 19933931 Our results reveal a critical role of miR-1 in mediating the effects of the IGF-1 pathway and demonstrate a feedback loop between miR-1 expression and the IGF-1 signal transduction cascade. -transcription factor target hsa-mir-183 "Carcinoma, Rectal" 19935649 "Moreover, miR-200c, miR-203 and miR-183 cooperate to suppress expression of stem cell factors in cancer cells and mouse embryonic stem (ES) cells, as demonstrated for the polycomb repressor Bmi1." -transcription factor target hsa-mir-200c "Carcinoma, Rectal" 19935649 "Moreover, miR-200c, miR-203 and miR-183 cooperate to suppress expression of stem cell factors in cancer cells and mouse embryonic stem (ES) cells, as demonstrated for the polycomb repressor Bmi1." -transcription factor target hsa-mir-203 "Carcinoma, Rectal" 19935649 "Moreover, miR-200c, miR-203 and miR-183 cooperate to suppress expression of stem cell factors in cancer cells and mouse embryonic stem (ES) cells, as demonstrated for the polycomb repressor Bmi1." -transcription factor target hsa-mir-15a Myeloproliferative Neoplasms 20008792 "STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease." -transcription factor target hsa-mir-15b Myeloproliferative Neoplasms 20008792 "STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease." -transcription factor target hsa-mir-16 Myeloproliferative Neoplasms 20008792 "STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease." -transcription factor target hsa-mir-17 "Lymphoma, B-Cell" 20008931 The miR-17 approximately 92 cluster is frequently amplified or overexpressed in human cancers and has emerged as the prototypical oncogenic polycistron microRNA (miRNA) -transcription factor target hsa-mir-18 "Lymphoma, B-Cell" 20008931 The miR-17 approximately 93 cluster is frequently amplified or overexpressed in human cancers and has emerged as the prototypical oncogenic polycistron microRNA (miRNA) -transcription factor target hsa-mir-19a "Lymphoma, B-Cell" 20008931 The miR-17 approximately 94 cluster is frequently amplified or overexpressed in human cancers and has emerged as the prototypical oncogenic polycistron microRNA (miRNA) -transcription factor target hsa-mir-19b-1 "Lymphoma, B-Cell" 20008931 The miR-17 approximately 95 cluster is frequently amplified or overexpressed in human cancers and has emerged as the prototypical oncogenic polycistron microRNA (miRNA) -transcription factor target hsa-mir-20a "Lymphoma, B-Cell" 20008931 The miR-17 approximately 96 cluster is frequently amplified or overexpressed in human cancers and has emerged as the prototypical oncogenic polycistron microRNA (miRNA) -transcription factor target hsa-mir-92-1 "Lymphoma, B-Cell" 20008931 The miR-17 approximately 96 cluster is frequently amplified or overexpressed in human cancers and has emerged as the prototypical oncogenic polycistron microRNA (miRNA) -transcription factor target hsa-mir-24 Vascular Disease [unspecific] 20019669 Inhibition of miR-24 by antisense oligonuclotides abrogates the downregulation of Trb3 as well as pro-synthetic activity of the PDGF-signalling pathway. -transcription factor target hsa-mir-223 "Leukemia, Myeloid, Acute" 20029046 "Our study supports a molecular network involving miR-223, C/EBPalpha, and E2F1 as major components of the granulocyte differentiation program, which is deregulated in AML." -transcription factor target hsa-mir-141 "Carcinoma, Nasopharyngeal" 20053927 "We propose that miR-141- and tumor-related genes c-MYC, SPLUNC1, BRD3, UBAP1 and PTEN may constitute a gene-miRNA network to contribute to NPC development." -transcription factor target hsa-mir-21 "Adenocarcinoma, Pancreatic Ductal" 20093556 Our findings indicate that miR-21 warrants further investigation as a marker for early detection of PDAC. -transcription factor target hsa-mir-21 Gliosis 20130193 We find that the two receptors exert opposing effects on the posttranscriptional regulation of astrocytic microRNA-21. -transcription factor target hsa-mir-9 Breast Neoplasms 20173743 "The microRNA miR-9 is induced by Myc in breast cancer cells where it targets the major epithelial adherens junction protein, E-cadherin." -transcription factor target hsa-mir-155 "Adenocarcinoma, Gastric" 20209161 "Taken together, our study describes, in the context of an H. pylori infection, a direct link between Foxp3 and miR-155 in human T cells and highlights the significance of cAMP in this miR-155 induction cascade." -transcription factor target hsa-mir-126 Vascular Disease [unspecific] 20364122 "We further find that angiogenic sprouting of AA vessels requires a flow-induced genetic pathway in which the mechano-sensitive zinc finger transcription factor klf2a induces expression of an endothelial-specific microRNA, mir-126, to activate Vegf signalling." -transcription factor target hsa-mir-34a Acute Kidney Failure 20386864 MicroRNA-34a is induced via p53 during cisplatin nephrotoxicity and contributes to cell survival. -transcription factor target hsa-let-7d Idiopathic Pulmonary Fibrosis 20395557 The down-regulation of let-7d in IPF and the profibrotic effects of this down-regulation in vitro and in vivo suggest a key regulatory role for this microRNA in preventing lung fibrosis. -transcription factor target hsa-mir-200a Bladder Neoplasms 20473948 "we observe that the mesoderm transcription factor TWIST1 and miR-200 expression are inversely correlated in bladder tumor samples and cell lines. TWIST1 associates directly with the miR-200 and miR-205 promoters, and may act as a repressor of miR-200 and miR-205 expression." -transcription factor target hsa-mir-200b Bladder Neoplasms 20473948 "we observe that the mesoderm transcription factor TWIST1 and miR-200 expression are inversely correlated in bladder tumor samples and cell lines. TWIST1 associates directly with the miR-200 and miR-205 promoters, and may act as a repressor of miR-200 and miR-205 expression." -transcription factor target hsa-mir-200c Bladder Neoplasms 20473948 "we observe that the mesoderm transcription factor TWIST1 and miR-200 expression are inversely correlated in bladder tumor samples and cell lines. TWIST1 associates directly with the miR-200 and miR-205 promoters, and may act as a repressor of miR-200 and miR-205 expression." -transcription factor target hsa-mir-205 Bladder Neoplasms 20473948 "we observe that the mesoderm transcription factor TWIST1 and miR-200 expression are inversely correlated in bladder tumor samples and cell lines. TWIST1 associates directly with the miR-200 and miR-205 promoters, and may act as a repressor of miR-200 and miR-205 expression." -transcription factor target hsa-mir-22 Neoplasms [unspecific] 20523723 Our results suggest that miR-22 acts to fine-tune the dynamics of PTEN/AKT/FoxO1 pathway. -transcription factor target hsa-mir-107 Neoplasms [unspecific] 20833636 p53 activates the PANK1/miRNA-107 gene leading to downregulation of CDK6 and p130 cell cycle proteins. -transcription factor target hsa-mir-1 "Leukemia, Myeloid, Acute" 20842122 Our data showed that EVI1 controls proliferation in AML through modulation of miR-1-2. This study contributes to further understand the transcriptional networks involving transcription factors and miRNAs in AML. -transcription factor target hsa-mir-106a Neoplasms [unspecific] 20878079 "The miR-17 family, composed of miR-17-5p, miR-20a/b, miR-106a/b and miR-93, has been demonstrated to take part in critical pathways that regulate cellular life and death decisions during normal development and in malignancy." -transcription factor target hsa-mir-106b Neoplasms [unspecific] 20878079 "The miR-17 family, composed of miR-17-5p, miR-20a/b, miR-106a/b and miR-93, has been demonstrated to take part in critical pathways that regulate cellular life and death decisions during normal development and in malignancy." -transcription factor target hsa-mir-17 Neoplasms [unspecific] 20878079 "The miR-17 family, composed of miR-17-5p, miR-20a/b, miR-106a/b and miR-93, has been demonstrated to take part in critical pathways that regulate cellular life and death decisions during normal development and in malignancy." -transcription factor target hsa-mir-20a Neoplasms [unspecific] 20878079 "The miR-17 family, composed of miR-17-5p, miR-20a/b, miR-106a/b and miR-93, has been demonstrated to take part in critical pathways that regulate cellular life and death decisions during normal development and in malignancy." -transcription factor target hsa-mir-20b Neoplasms [unspecific] 20878079 "The miR-17 family, composed of miR-17-5p, miR-20a/b, miR-106a/b and miR-93, has been demonstrated to take part in critical pathways that regulate cellular life and death decisions during normal development and in malignancy." -transcription factor target hsa-mir-93 Neoplasms [unspecific] 20878079 "The miR-17 family, composed of miR-17-5p, miR-20a/b, miR-106a/b and miR-93, has been demonstrated to take part in critical pathways that regulate cellular life and death decisions during normal development and in malignancy." -transcription factor target hsa-mir-322 Myocardial Infarction 20972335 These results suggest that miR-322/424 plays an important physiological role in post-ischemic vascular remodeling and angiogenesis. -transcription factor target hsa-mir-424 Myocardial Infarction 20972335 These results suggest that miR-322/424 plays an important physiological role in post-ischemic vascular remodeling and angiogenesis. -transcription factor target hsa-mir-16 Gastric Neoplasms 21081469 NF-¦ÊB targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptors. -transcription factor target hsa-mir-21 Gastric Neoplasms 21081469 NF-¦ÊB targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptors. -transcription factor target hsa-mir-143 Pancreatic Neoplasms 21159816 "Additionally, KRAS and RREB1 are targets of miR-143/miR-145, revealing a feed-forward mechanism that potentiates Ras signaling." -transcription factor target hsa-mir-145 Pancreatic Neoplasms 21159816 "Additionally, KRAS and RREB1 are targets of miR-143/miR-145, revealing a feed-forward mechanism that potentiates Ras signaling." -transcription factor target hsa-mir-499 Myocardial Infarction 21186368 Here we report that modulation of microRNA-499 (miR-499) levels affects apoptosis and the severity of myocardial infarction and cardiac dysfunction induced by ischemia-reperfusion. -transcription factor target hsa-mir-200c Breast Neoplasms 21336307 "This study elucidates a role for p53 in regulating EMT-MET (mesenchymal-epithelial transition) and stemness or differentiation plasticity, and reveals a potential therapeutic implication to suppress EMT-associated cancer stem cells through activation of the p53-miR-200c pathway." -transcription factor target hsa-mir-193a Squamous Cell Carcinoma 21436470 "The resulting feed-forward circuit involving p63, miR-193a-5p and p73 controls p73 levels, cell viability and DNA damage susceptibility in certain cancers including squamous cell carcinoma." -transcription factor target hsa-mir-15a Retinoblastoma 21454377 "In particular, miRs encoded by the miR-15a, miR-16-1 cluster seem to act as tumor suppressors. Here, we evidence that the miR-15a, miR-16-1 cluster and related miR-15b, miR-16-2 cluster comprise miRs regulated by E2F1, a pivotal transcription factor that can induce both proliferation and cell death." -transcription factor target hsa-mir-15b Retinoblastoma 21454377 "In particular, miRs encoded by the miR-15a, miR-16-1 cluster seem to act as tumor suppressors. Here, we evidence that the miR-15a, miR-16-1 cluster and related miR-15b, miR-16-2 cluster comprise miRs regulated by E2F1, a pivotal transcription factor that can induce both proliferation and cell death." -transcription factor target hsa-mir-16-1 Retinoblastoma 21454377 "In particular, miRs encoded by the miR-15a, miR-16-1 cluster seem to act as tumor suppressors. Here, we evidence that the miR-15a, miR-16-1 cluster and related miR-15b, miR-16-2 cluster comprise miRs regulated by E2F1, a pivotal transcription factor that can induce both proliferation and cell death." -transcription factor target hsa-mir-16-2 Retinoblastoma 21454377 "In particular, miRs encoded by the miR-15a, miR-16-1 cluster seem to act as tumor suppressors. Here, we evidence that the miR-15a, miR-16-1 cluster and related miR-15b, miR-16-2 cluster comprise miRs regulated by E2F1, a pivotal transcription factor that can induce both proliferation and cell death." -transcription factor target hsa-mir-34a Ovarian Neoplasms 21516127 "MiRIDIAN-based knockdown and induction of miR-34a evidenced a direct regulatory link between miR-34a and E2F3a, and the tumor-suppressive character of miR-34a was documented by its association with improved survival." -transcription factor target hsa-mir-193a "Adenocarcinoma, Colon" 21670079 "Finally, expression of miR-193a is inversely correlated with PLAU and K-Ras in human colon adenocarcinomas." -transcription factor target hsa-mir-21 "Carcinoma, Colon" 21956205 our findings identify direct transcriptional regulation of miR-21 by TCF4 and suggest a role for miR-21 in cancer cell proliferation and invasion upon activation of ¦Â-catenin/TCF4 signaling. -transcription factor target hsa-mir-182 Breast Neoplasms 22086602 We demonstrated that DDX5 regulated a subset of MicroRNAs including miR-21 and miR-182 in basal breast cancer cells. -transcription factor target hsa-mir-21 Breast Neoplasms 22086602 We demonstrated that DDX5 regulated a subset of MicroRNAs including miR-21 and miR-182 in basal breast cancer cells. -transcription factor target hsa-mir-124 Liver Neoplasms 22153071 "we show that transient inhibition of HNF4¦Á initiates hepatocellular transformation through a microRNA-inflammatory feedback loop circuit consisting of miR-124, IL6R, STAT3, miR-24, and miR-629." -transcription factor target hsa-mir-24 Liver Neoplasms 22153071 "we show that transient inhibition of HNF4¦Á initiates hepatocellular transformation through a microRNA-inflammatory feedback loop circuit consisting of miR-124, IL6R, STAT3, miR-24, and miR-629." -transcription factor target hsa-mir-629 Liver Neoplasms 22153071 "we show that transient inhibition of HNF4¦Á initiates hepatocellular transformation through a microRNA-inflammatory feedback loop circuit consisting of miR-124, IL6R, STAT3, miR-24, and miR-629." -transcription factor target hsa-mir-21 "Squamous Cell Carcinoma, Skin or Unspecific" 22614019 These findings indicate that decreased Grhl3 expression contributes to tumor progression and upregulation of the oncomir miR-21 in squamous cell carcinoma of the skin. -transcription factor target hsa-mir-143 Colorectal Carcinoma 22751122 These results establish a complex network of regulation through which the miR-143/145 cluster is able to modulate KRAS signaling in colorectal cancer. -transcription factor target hsa-mir-145 Colorectal Carcinoma 22751122 These results establish a complex network of regulation through which the miR-143/145 cluster is able to modulate KRAS signaling in colorectal cancer. -transcription factor target hsa-mir-103 Breast Neoplasms 22908280 "Aside from the previously identified miR-200 family, these include the miR-15/16 (miR-16, miR-15b) and miR-103/107 (miR-103, miR-107) families as well as miR-145, miR-335, and miR-128b." -transcription factor target hsa-mir-107 Breast Neoplasms 22908280 "Aside from the previously identified miR-200 family, these include the miR-15/16 (miR-16, miR-15b) and miR-103/107 (miR-103, miR-107) families as well as miR-145, miR-335, and miR-128b." -transcription factor target hsa-mir-128b Breast Neoplasms 22908280 "Aside from the previously identified miR-200 family, these include the miR-15/16 (miR-16, miR-15b) and miR-103/107 (miR-103, miR-107) families as well as miR-145, miR-335, and miR-128b." -transcription factor target hsa-mir-145 Breast Neoplasms 22908280 "Aside from the previously identified miR-200 family, these include the miR-15/16 (miR-16, miR-15b) and miR-103/107 (miR-103, miR-107) families as well as miR-145, miR-335, and miR-128b." -transcription factor target hsa-mir-15b Breast Neoplasms 22908280 "Aside from the previously identified miR-200 family, these include the miR-15/16 (miR-16, miR-15b) and miR-103/107 (miR-103, miR-107) families as well as miR-145, miR-335, and miR-128b." -transcription factor target hsa-mir-16 Breast Neoplasms 22908280 "Aside from the previously identified miR-200 family, these include the miR-15/16 (miR-16, miR-15b) and miR-103/107 (miR-103, miR-107) families as well as miR-145, miR-335, and miR-128b." -transcription factor target hsa-mir-335 Breast Neoplasms 22908280 "Aside from the previously identified miR-200 family, these include the miR-15/16 (miR-16, miR-15b) and miR-103/107 (miR-103, miR-107) families as well as miR-145, miR-335, and miR-128b." -transcription factor target hsa-mir-199a Liver Cirrhosis 22942713 This review provides a comprehensive survey of the literature on miR-199a as an example of the complexity of miRNA biology and suggests future directions for miRNA research. -transcription factor target hsa-mir-26a Lymphoma 23338972 "Our investigation of the mechanisms underlying the decrease in miR-26a in this lymphoma revealed novel evidence that STAT3, a major downstream substrate of NPM-ALK tyrosine kinase activity,suppresses MIR26A1 gene expression." -transcription factor target hsa-mir-205 Breast Neoplasms 23474752 Loss of the polycomb protein Mel-18 enhances the epithelial-mesenchymal transition by ZEB1 and ZEB2 expression through the downregulation of miR-205 in breast cancer. -transcription factor target hsa-mir-26a Lymphoma 23538750 Loss- or gain-of-function approaches revealed that miR-26a functioned as a tumor suppressor miRNA and mediated the combinatorial effects of JQ1 and DZNep. -transcription factor target hsa-mir-183 Neuroblastoma 23625969 MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma. -transcription factor target hsa-mir-155 "Leukemia, Myeloid, Acute" 24263100 "The silencing of Ago2 impairs the D3-dependent miR-17-5p/20a/106a, miR-125b and miR-155 downregulation, the accumulation of their translational targets AML1, VDR and C/EBPβ and monocytic cell differentiation." -transcription factor target hsa-mir-17 "Leukemia, Myeloid, Acute" 24263100 "The silencing of Ago2 impairs the D3-dependent miR-17-5p/20a/106a, miR-125b and miR-155 downregulation, the accumulation of their translational targets AML1, VDR and C/EBPβ and monocytic cell differentiation." -transcription factor target hsa-mir-17 Toxoplasma gondii Infection 24341525 "We demonstrated that miR-30c-1, miR-125b-2, miR-23b-27b-24-1 and miR-17 ~â€?2 cluster genes were transactivated through promoter binding of the STAT3 following T. gondii infection." -transcription factor target hsa-mir-126 Myocardial Infarction 25200057 Exosomes purified from endothelial cells overexpressing HIF1 had higher contents of miR-126 and miR-210. -transcription factor target hsa-mir-98 Atherosclerosis 25623956 Coculturing ECs with sSMCs under static condition causes initial increases of 4 anti-inflammatory miRs (146a/708/451/98) in ECs followed by decreases below basal levels at 7 days; -transcription factor target hsa-mir-182 Colorectal Carcinoma 25755709 Fentanyl also downregulated the expression of β-catenin and miR-182 in both xenograft tumors and HCT116 cells -transcription factor target hsa-mir-146a Inflammation 26718614 miR-146a inhibits inflammatory activation. -transcription factor target hsa-mir-21 Colon Neoplasms 26853468 a DHA-enriched diet induced a decrease of human miR-21 expression and an increase of human TNFα mRNA expression limiting tumor growth in a cancer cell-derived TNFα dependent manner. -transcription factor target hsa-let-7a Lung Neoplasms 26962302 The present study reveals that decreased C/EBPα contributes to the down-regulation of miRNA let-7a-1 in lung cancer cells. -transcription factor target hsa-mir-200b "Adenocarcinoma, Lung" 27027446 the double-negative feedback loop between E2F3b and miR-200b regulates docetaxel chemosensitivity of human LAD cells -transcription factor target hsa-mir-142 "Leukemia, Promyelocytic, Acute" 27480083 Our results suggest the existence of a Vav1/PU.1/miR-142-3p network that supports ATRA-induced differentiation in APL-derived cells -transcription factor target hsa-mir-7 "Carcinoma, Hepatocellular" 27519414 Suppression of MicroRNA-7 (miR-7) Biogenesis by Nuclear Factor 90-Nuclear Factor 45 Complex (NF90-NF45) Controls Cell Proliferation in Hepatocellular Carcinoma. -transcription factor target hsa-mir-199a-2 Sickle Cell Disease 27573019 Activated Transcription Factor 3 in Association with Histone Deacetylase 6 Negatively Regulates MicroRNA 199a2 Transcription by Chromatin Remodeling and Reduces Endothelin-1 Expression. -transcription factor target hsa-mir-34a "Adenocarcinoma, Pancreatic Ductal" 27594424 EZH2 coupled with HOTAIR to silence MicroRNA-34a by the induction of heterochromatin formation in human pancreatic ductal adenocarcinoma. -transcription factor target hsa-mir-22 "Leukemia, Myeloid, Acute" 27617961 The PU.1-Modulated MicroRNA-22 Is a Regulator of Monocyte/Macrophage Differentiation and Acute Myeloid Leukemia. -transcription factor target hsa-mir-1246 "Carcinoma, Hepatocellular" 27639189 Octamer 4/microRNA-1246 signaling axis drives Wnt/¦Â-catenin activation in liver cancer stem cells. -transcription factor target hsa-mir-126 Vascular Disease [unspecific] 27780851 "GATA2-mediated regulation of miR-126 and miR-221 has an important impact on endothelial biology. Hence, modulation of GATA2 and its targets miR-126 and miR-221 is a promising therapeutic strategy for treatment of many vascular diseases" -transcription factor target hsa-mir-221 Vascular Disease [unspecific] 27780851 "GATA2-mediated regulation of miR-126 and miR-221 has an important impact on endothelial biology. Hence, modulation of GATA2 and its targets miR-126 and miR-221 is a promising therapeutic strategy for treatment of many vascular diseases" -transcription factor target hsa-mir-424 Prostate Neoplasms 27820701 MicroRNA-424 impairs ubiquitination to activate STAT3 and promote prostate tumor progression. -transcription factor target hsa-mir-29b "Carcinoma, Ovarian" 27832631 A Double-Negative Feedback Interaction between MicroRNA-29b and DNMT3A/3B Contributes to Ovarian Cancer Progression. -transcription factor target hsa-mir-127 "Carcinoma, Lung" 27869168 miR-127 promotes EMT and stem-like traits in lung cancer through a feed-forward regulatory loop. -transcription factor target hsa-mir-126 Atherosclerosis 27870587 17¦Â-Estradiol Enhances Vascular Endothelial Ets-1/miR-126-3p Expression: The Possible Mechanism for Attenuation of Atherosclerosis. -transcription factor target hsa-mir-33 Atherosclerosis 27905947 Fibroblast growth factor 21 potentially inhibits microRNA-33 expression to affect macrophage actions. -transcription factor target hsa-mir-148a "Carcinoma, Bladder" 27906180 miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer. -transcription factor target hsa-mir-31 "Carcinoma, Hepatocellular" 27909734 Klf4 inhibits tumor growth and metastasis by targeting microRNA-31 in human hepatocellular carcinoma. -transcription factor target hsa-mir-3158 Neoplasms [unspecific] 27919789 "Unravelling a p73-regulated network: The role of a novel p73-dependent target, MIR3158, in cancer cell migration and invasiveness." -transcription factor target hsa-mir-31 Colon Neoplasms 27926494 p38 and JNK pathways control E-selectin-dependent extravasation of colon cancer cells by modulating miR-31 transcription. -transcription factor target hsa-mir-493 Neoplasms [unspecific] 27956702 Snail-Modulated MicroRNA 493 Forms a Negative Feedback Loop with the Insulin-Like Growth Factor 1 Receptor Pathway and Blocks Tumorigenesis. -transcription factor target hsa-mir-520d "Carcinoma, Gastric" 28011625 Gastric Cancer Cell Proliferation and Survival Is Enabled by a Cyclophilin B/STAT3/miR-520d-5p Signaling Feedback Loop. -transcription factor target hsa-mir-574 "Carcinoma, Gastric" 28042090 Upregulation of microRNA-574-3p in a human gastric cancer cell line AGS by TGF-¦Â1. -transcription factor target hsa-mir-23b "Carcinoma, Cervical" 28077801 Human papillomavirus type 16 E6 suppresses microRNA-23b expression in human cervical cancer cells through DNA methylation of the host gene C9orf3. -transcription factor target hsa-mir-101 "Carcinoma, Breast" 28109909 ERK2-ZEB1-miR-101-1 axis contributes to epithelial-mesenchymal transition and cell migration in cancer. -transcription factor target hsa-mir-139 Neoplasms [unspecific] 28119089 The p53 protein induces stable miRNAs that have the potential to modify subsequent p53 responses. -transcription factor target hsa-mir-143 Neoplasms [unspecific] 28119089 The p53 protein induces stable miRNAs that have the potential to modify subsequent p53 responses. -transcription factor target hsa-mir-145 Neoplasms [unspecific] 28119089 The p53 protein induces stable miRNAs that have the potential to modify subsequent p53 responses. -transcription factor target hsa-mir-34a Neoplasms [unspecific] 28119089 The p53 protein induces stable miRNAs that have the potential to modify subsequent p53 responses. -transcription factor target hsa-mir-519d "Carcinoma, Ovarian" 28146423 E2F-1 targets miR-519d to regulate the expression of the ras homolog gene family member C. -transcription factor target hsa-mir-181b "Carcinoma, Prostate" 28184935 Involvement of EZH2 in aerobic glycolysis of prostate cancer through miR-181b/HK2 axis. -transcription factor target hsa-mir-30a "Carcinoma, Ovarian" 28222434 A Feedback Loop Between miR-30a/c-5p and DNMT1 Mediates Cisplatin Resistance in Ovarian Cancer Cells. -transcription factor target hsa-mir-30c "Carcinoma, Ovarian" 28222434 A Feedback Loop Between miR-30a/c-5p and DNMT1 Mediates Cisplatin Resistance in Ovarian Cancer Cells. -transcription factor target hsa-mir-146a "Leukemia, Myeloid, Acute" 28399410 Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia. -transcription factor target hsa-mir-423 "Diabetes Mellitus, Type 2" 28411267 NFE2 Induces miR-423-5p to Promote Gluconeogenesis and Hyperglycemia by Repressing the Hepatic FAM3A-ATP-Akt Pathway. -transcription factor target hsa-mir-182 Melanoma 28412746 Kr¨¹ppel-like factor 4 (KLF4) regulates the miR-183~96~182 cluster under physiologic and pathologic conditions. -transcription factor target hsa-mir-183 Melanoma 28412746 Kr¨¹ppel-like factor 4 (KLF4) regulates the miR-183~96~182 cluster under physiologic and pathologic conditions. -transcription factor target hsa-mir-96 Melanoma 28412746 Kr¨¹ppel-like factor 4 (KLF4) regulates the miR-183~96~182 cluster under physiologic and pathologic conditions. -transcription factor target hsa-mir-192 "Carcinoma, Hepatocellular" 28465351 An HNF4¦Á-microRNA-194/192 signaling axis maintains hepatic cell function. -transcription factor target hsa-mir-194 "Carcinoma, Hepatocellular" 28465351 An HNF4¦Á-microRNA-194/192 signaling axis maintains hepatic cell function. -transcription factor target hsa-mir-21 Pulmonary Hypertension 28522568 Peroxisome proliferator-activated receptor-¦Ã enhances human pulmonary artery smooth muscle cell apoptosis through microRNA-21 and programmed cell death 4. -transcription factor target hsa-mir-29a Atherosclerosis 28593745 ox-LDL increases microRNA-29a transcription through upregulating YY1 and STAT1 in macrophages. -transcription factor target hsa-mir-182 "Leukemia, Myeloid, Acute" 28663557 Disruption of the C/EBP¦Á-miR-182 balance impairs granulocytic differentiation. -transcription factor target hsa-mir-192 Neoplasms [unspecific] 19074876 Our results showing a role for miR-192/215 in cell proliferation combined with recent observations that these miRNAs are underexpressed in primary cancers support the idea that miR-192 and miR-215 function as tumor suppressors. -transcription factor target hsa-mir-215 Neoplasms [unspecific] 19074876 Our results showing a role for miR-192/215 in cell proliferation combined with recent observations that these miRNAs are underexpressed in primary cancers support the idea that miR-192 and miR-215 function as tumor suppressors. -transcription factor target hsa-mir-1-1 Inflammation 20098732 "Low density miR array demonstrated that TWEAK inhibits the expression of several miRs including muscle-specific miR-1-1, miR-1-2, miR-133a, miR-133b and miR-206." -transcription factor target hsa-mir-1-2 Inflammation 20098732 "Low density miR array demonstrated that TWEAK inhibits the expression of several miRs including muscle-specific miR-1-1, miR-1-2, miR-133a, miR-133b and miR-206." -transcription factor target hsa-mir-133a Inflammation 20098732 "Low density miR array demonstrated that TWEAK inhibits the expression of several miRs including muscle-specific miR-1-1, miR-1-2, miR-133a, miR-133b and miR-206." -transcription factor target hsa-mir-133b Inflammation 20098732 "Low density miR array demonstrated that TWEAK inhibits the expression of several miRs including muscle-specific miR-1-1, miR-1-2, miR-133a, miR-133b and miR-206." -transcription factor target hsa-mir-206 Inflammation 20098732 "Low density miR array demonstrated that TWEAK inhibits the expression of several miRs including muscle-specific miR-1-1, miR-1-2, miR-133a, miR-133b and miR-206." -transcription factor target hsa-mir-34a Breast Neoplasms 26553365 Here we show that SNAI2 down-regulates miR34a expression in hypoxic MCF7 cell-derived mammospheres. -transcription factor target hsa-let-7 Prostate Neoplasms 27197175 "In cancer cells, reduced expression of ESE3/EHF upregulated Lin28A and Lin28B and downregulated the let-7 microRNAs." -transcription factor target hsa-mir-132 Glioma 27522003 "The expression of miR-132 was low in human glioma tissues, and the downregulated expression was associated with advanced glioma grades." -transcription factor target hsa-mir-124 Hepatitis C Virus Infection 27753084 Decline of miR-124 in myeloid cells promotes regulatory T-cell development in hepatitis C virus infection. -transcription factor target hsa-mir-26a "Lymphoma, Burkitt" 18713946 "Interestingly, miR-26a was also found to be deregulated in primary human Burkitt lymphoma samples, thereby probably being of clinical relevance." -transcription factor target hsa-mir-141 Liver Neoplasms 19167416 "the livers of 2-AAF-exposed rats were characterized by the substantial deregulation of expression of miR-18, miR-21, miR-182, and miR-200 family, microRNAs involved in control of apoptosis/cell proliferation and cell-cell contact pathways, two major pathways disrupted during the promotion stage of hepatocarcinogenesis" -transcription factor target hsa-mir-18 Liver Neoplasms 19167416 "the livers of 2-AAF-exposed rats were characterized by the substantial deregulation of expression of miR-18, miR-21, miR-182, and miR-200 family, microRNAs involved in control of apoptosis/cell proliferation and cell-cell contact pathways, two major pathways disrupted during the promotion stage of hepatocarcinogenesis" -transcription factor target hsa-mir-182 Liver Neoplasms 19167416 "the livers of 2-AAF-exposed rats were characterized by the substantial deregulation of expression of miR-18, miR-21, miR-182, and miR-200 family, microRNAs involved in control of apoptosis/cell proliferation and cell-cell contact pathways, two major pathways disrupted during the promotion stage of hepatocarcinogenesis" -transcription factor target hsa-mir-200a Liver Neoplasms 19167416 "the livers of 2-AAF-exposed rats were characterized by the substantial deregulation of expression of miR-18, miR-21, miR-182, and miR-200 family, microRNAs involved in control of apoptosis/cell proliferation and cell-cell contact pathways, two major pathways disrupted during the promotion stage of hepatocarcinogenesis" -transcription factor target hsa-mir-200b Liver Neoplasms 19167416 "the livers of 2-AAF-exposed rats were characterized by the substantial deregulation of expression of miR-18, miR-21, miR-182, and miR-200 family, microRNAs involved in control of apoptosis/cell proliferation and cell-cell contact pathways, two major pathways disrupted during the promotion stage of hepatocarcinogenesis" -transcription factor target hsa-mir-200c Liver Neoplasms 19167416 "the livers of 2-AAF-exposed rats were characterized by the substantial deregulation of expression of miR-18, miR-21, miR-182, and miR-200 family, microRNAs involved in control of apoptosis/cell proliferation and cell-cell contact pathways, two major pathways disrupted during the promotion stage of hepatocarcinogenesis" -transcription factor target hsa-mir-21 Liver Neoplasms 19167416 "the livers of 2-AAF-exposed rats were characterized by the substantial deregulation of expression of miR-18, miR-21, miR-182, and miR-200 family, microRNAs involved in control of apoptosis/cell proliferation and cell-cell contact pathways, two major pathways disrupted during the promotion stage of hepatocarcinogenesis" -transcription factor target hsa-mir-429 Liver Neoplasms 19167416 "the livers of 2-AAF-exposed rats were characterized by the substantial deregulation of expression of miR-18, miR-21, miR-182, and miR-200 family, microRNAs involved in control of apoptosis/cell proliferation and cell-cell contact pathways, two major pathways disrupted during the promotion stage of hepatocarcinogenesis" -transcription factor target hsa-mir-143 Atherosclerosis 20351064 "Thus, dysregulation of the miR-143 and -145 genes is causally involved in the aberrant SMC plasticity encountered during vascular disease, in part through the up-regulation of an autoregulatory loop that promotes podosome formation." -transcription factor target hsa-mir-145 Atherosclerosis 20351064 "Thus, dysregulation of the miR-143 and -145 genes is causally involved in the aberrant SMC plasticity encountered during vascular disease, in part through the up-regulation of an autoregulatory loop that promotes podosome formation." -transcription factor target hsa-mir-1275 Glioblastoma 25129238 "We show miR-210-3p, miR-1275, miR-376c-3p, miR-23b-3p, miR-193a-3p and miR-145-5p to be up-regulated, while miR-92b-3p, miR-20a-5p, miR-10b-5p, miR-181a-2-3p and miR-185-5p are down-regulated by hypoxia." -transcription factor target hsa-mir-146a "Carcinoma, Thyroid, Anaplastic" 20061417 Nuclear factor-{kappa}B contributes to anaplastic thyroid carcinomas through up-regulation of miR-146a. -transcription factor target hsa-mir-146a Inflammation 20098732 The expression of a few miRs including miR-146a and miR-455 was found to be significantly increased in response to TWEAK treatment. -transcription factor target hsa-mir-455 Inflammation 20098732 The expression of a few miRs including miR-146a and miR-455 was found to be significantly increased in response to TWEAK treatment. -transcription factor target hsa-mir-221 Melanoma 21711453 "MicroRNAs-221 and -222 are highly upregulated in several solid tumors, including melanomas." -transcription factor target hsa-mir-222 Melanoma 21711453 "MicroRNAs-221 and -222 are highly upregulated in several solid tumors, including melanomas." -transcription factor target hsa-mir-145 Bladder Neoplasms 26196183 The most hypoxia-upregulated miRNA was miR-145. -transcription factor target hsa-mir-34a Alzheimer Disease 27235866 miR-34a over expression in patient's tissue -transcription factor target hsa-mir-146a "Lymphoma, B-Cell" 18066065 c-Myc repressed this miRNA -transcription factor target hsa-mir-150 "Lymphoma, B-Cell" 18066065 c-Myc repressed this miRNA -transcription factor target hsa-mir-15a "Lymphoma, B-Cell" 18066065 c-Myc repressed this miRNA -transcription factor target hsa-mir-195 "Lymphoma, B-Cell" 18066065 c-Myc repressed this miRNA -transcription factor target hsa-mir-22 "Lymphoma, B-Cell" 18066065 c-Myc repressed this miRNA -transcription factor target hsa-mir-26b "Lymphoma, B-Cell" 18066065 c-Myc repressed this miRNA -transcription factor target hsa-mir-29a "Lymphoma, B-Cell" 18066065 c-Myc repressed this miRNA -transcription factor target hsa-mir-29c "Lymphoma, B-Cell" 18066065 c-Myc repressed this miRNA -transcription factor target hsa-mir-30e "Lymphoma, B-Cell" 18066065 c-Myc repressed this miRNA -transcription factor target hsa-mir-34a "Lymphoma, B-Cell" 18066065 c-Myc repressed this miRNA -transcription factor target hsa-mir-210 Breast Neoplasms 18316553 induced -transcription factor target hsa-mir-221 Melanoma 18417445 suppressing -transcription factor target hsa-mir-222 Melanoma 18417445 suppressing -transcription factor target hsa-mir-19a PTEN Hamartoma Tumor Tyndrome 18460397 overexpressed -transcription factor target hsa-mir-21 PTEN Hamartoma Tumor Tyndrome 18460397 overexpressed -transcription factor target hsa-mir-425 Glioblastoma 18765229 up-regulation in the CD133-cells -transcription factor target hsa-mir-451a Glioblastoma 18765229 miR-451: MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells -transcription factor target hsa-mir-486 Glioblastoma 18765229 up-regulation in the CD133-cells -transcription factor target hsa-mir-1-1 Lung Neoplasms 18818206 miR-1: Down-regulation -transcription factor target hsa-mir-1-2 Lung Neoplasms 18818206 miR-1: Down-regulation -transcription factor target hsa-mir-21 Neoplasms [unspecific] 18850008 "miR-21: oncomir, An autoregulatory loop mediated by miR-21 and PDCD4 controls the AP-1 activity in RAS transformation" -transcription factor target hsa-mir-29a Rhabdomyosarcoma 18977326 miR-29: NF-kappaB-YY1-miR-29 regulatory circuitry -transcription factor target hsa-mir-192 Colon Neoplasms 19088023 miR-192: the effect of miR-192 on cellular proliferation is mainly p53 dependent -transcription factor target hsa-mir-17 "Leukemia-Lymphoma, Adult T-Cell" 19148830 miR-17: Activation of miR-17-92 by NK-like homeodomain proteins suppresses apoptosis via reduction of E2F1 in T-cell acute lymphoblastic leukemia -transcription factor target hsa-mir-18a "Leukemia-Lymphoma, Adult T-Cell" 19148830 miR-18a: Activation of miR-17-92 by NK-like homeodomain proteins suppresses apoptosis via reduction of E2F1 in T-cell acute lymphoblastic leukemia -transcription factor target hsa-mir-19a "Leukemia-Lymphoma, Adult T-Cell" 19148830 miR-19a: Activation of miR-17-92 by NK-like homeodomain proteins suppresses apoptosis via reduction of E2F1 in T-cell acute lymphoblastic leukemia -transcription factor target hsa-mir-19b-1 "Leukemia-Lymphoma, Adult T-Cell" 19148830 miR-19b: Activation of miR-17-92 by NK-like homeodomain proteins suppresses apoptosis via reduction of E2F1 in T-cell acute lymphoblastic leukemia -transcription factor target hsa-mir-19b-2 "Leukemia-Lymphoma, Adult T-Cell" 19148830 miR-19b: Activation of miR-17-92 by NK-like homeodomain proteins suppresses apoptosis via reduction of E2F1 in T-cell acute lymphoblastic leukemia -transcription factor target hsa-mir-20a "Leukemia-Lymphoma, Adult T-Cell" 19148830 miR-20a: Activation of miR-17-92 by NK-like homeodomain proteins suppresses apoptosis via reduction of E2F1 in T-cell acute lymphoblastic leukemia -transcription factor target hsa-mir-92a-1 "Leukemia-Lymphoma, Adult T-Cell" 19148830 miR-92a: Activation of miR-17-92 by NK-like homeodomain proteins suppresses apoptosis via reduction of E2F1 in T-cell acute lymphoblastic leukemia -transcription factor target hsa-mir-92a-2 "Leukemia-Lymphoma, Adult T-Cell" 19148830 miR-92a: Activation of miR-17-92 by NK-like homeodomain proteins suppresses apoptosis via reduction of E2F1 in T-cell acute lymphoblastic leukemia -transcription factor target hsa-mir-146a Breast Neoplasms 19190326 "miR-146: Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis" -transcription factor target hsa-mir-146b Breast Neoplasms 19190326 "miR-146: Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis" -transcription factor target hsa-mir-26a-1 Lymphoma 19197161 miR-26a: repressed by MYC -transcription factor target hsa-mir-26a-2 Lymphoma 19197161 miR-26a: repressed by MYC -transcription factor target hsa-mir-145 Neoplasms [unspecific] 19202062 "miR-145: putative tumor suppressor, miR-145 provides a direct link between p53 and c-Myc in this gene regulatory network" -transcription factor target hsa-mir-21 Breast Neoplasms 19264808 miR-21: Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells. -transcription factor target hsa-mir-21 Breast Neoplasms 19308091 miR-21: BMP-6 inhibits microRNA-21 expression in breast cancer through repressing deltaEF1 and AP-1 -transcription factor target hsa-mir-146a Osteoarthritis 19333945 miR-146a: miR-146 is intensely expressed in low-grade OA cartilage and that its expression is induced by stimulation of IL-1beta -transcription factor target hsa-mir-17 Medulloblastoma 19351822 miR-17: the most highly up-regulated miRNAs in medulloblastoma -transcription factor target hsa-mir-18a Medulloblastoma 19351822 miR-18a: the most highly up-regulated miRNAs in medulloblastoma -transcription factor target hsa-mir-19a Medulloblastoma 19351822 miR-19a: the most highly up-regulated miRNAs in medulloblastoma -transcription factor target hsa-mir-19b-1 Medulloblastoma 19351822 miR-19b: the most highly up-regulated miRNAs in medulloblastoma -transcription factor target hsa-mir-19b-2 Medulloblastoma 19351822 miR-19b: the most highly up-regulated miRNAs in medulloblastoma -transcription factor target hsa-mir-20a Medulloblastoma 19351822 miR-20a: the most highly up-regulated miRNAs in medulloblastoma -transcription factor target hsa-mir-92a-1 Medulloblastoma 19351822 miR-92a: the most highly up-regulated miRNAs in medulloblastoma -transcription factor target hsa-mir-92a-2 Medulloblastoma 19351822 miR-92a: the most highly up-regulated miRNAs in medulloblastoma -transcription factor target hsa-mir-222 Brain Neoplasms 19351827 miR-222: Overexpression -transcription factor target hsa-mir-222 Prostate Neoplasms 19351827 miR-222: Overexpression -transcription factor target hsa-mir-23a "Cardiomyopathy, Hypertrophic" 19574461 miR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy -transcription factor target hsa-mir-18a Neoplasms [unspecific] 19706389 "significantly upregulated, downregulate Eralpha" -transcription factor target hsa-mir-143 Wounds and Injuries [unspecific] 19720868 modulate cytoskeletal dynamics and responsiveness -transcription factor target hsa-mir-145 Wounds and Injuries [unspecific] 19720868 modulate cytoskeletal dynamics and responsiveness -transcription factor target hsa-mir-21 Prostate Neoplasms 19738047 hsa-mir-21: an androgen receptor-regulated microRNA that promotes hormone-dependent and hormone-independent prostate cancer growth -transcription factor target hsa-mir-223 "Leukemia, Myeloid, Acute" 20018373 miR-223:miR-223 suppression in AML is caused by impaired miR-223 upstream factors -transcription factor target hsa-mir-195 Schizophrenia 20156358 EGR3 and hsa-miR-195 were core regulators -transcription factor target hsa-mir-34a Disease of Metabolism 20185821 Our study demonstrates an unexpected role of the FXR/SHP pathway in controlling SIRT1 levels via miR-34a inhibition and that elevated miR-34a levels in obese mice contribute to decreased SIRT1 levels -transcription factor target hsa-mir-34a Neoplasms [unspecific] 20185821 Our study demonstrates an unexpected role of the FXR/SHP pathway in controlling SIRT1 levels via miR-34a inhibition and that elevated miR-34a levels in obese mice contribute to decreased SIRT1 levels -transcription factor target hsa-mir-221 "Leukemia, Lymphocytic, Chronic, B-Cell" 20203269 miR-221:miR-221/222 and p27 may represent a regulatory loop that helps maintaining CLL cells in a resting condition -transcription factor target hsa-mir-222 "Leukemia, Lymphocytic, Chronic, B-Cell" 20203269 miR-222:miR-221/222 and p27 may represent a regulatory loop that helps maintaining CLL cells in a resting condition -transcription factor target hsa-mir-519c Neoplasms [unspecific] 20233879 MicroRNA-519c suppresses hypoxia-inducible factor-1alpha expression and tumor angiogenesis -transcription factor target hsa-mir-210 Ischemia 20308562 demonstrated a key role of miR-210 in limiting keratinocyte proliferation -transcription factor target hsa-mir-221 Breast Neoplasms 20388878 These findings suggest that the negative regulatory loop involving miR-221-222 and ERalpha may confer proliferative advantage and migratory activity to breast cancer cells and promote the transition from ER-positive to ER-negative tumors -transcription factor target hsa-mir-222 Breast Neoplasms 20388878 These findings suggest that the negative regulatory loop involving miR-221-222 and ERalpha may confer proliferative advantage and migratory activity to breast cancer cells and promote the transition from ER-positive to ER-negative tumors -transcription factor target hsa-mir-106b Prostate Neoplasms 20388916 We showed that miR-22 and the miR-106b~25 cluster are aberrantly overexpressed in human prostate cancer -transcription factor target hsa-mir-22 Prostate Neoplasms 20388916 We showed that miR-22 and the miR-106b~25 cluster are aberrantly overexpressed in human prostate cancer -transcription factor target hsa-mir-25 Prostate Neoplasms 20388916 We showed that miR-22 and the miR-106b~25 cluster are aberrantly overexpressed in human prostate cancer -transcription factor target hsa-mir-93 Prostate Neoplasms 20388916 We showed that miR-22 and the miR-106b~25 cluster are aberrantly overexpressed in human prostate cancer -transcription factor target hsa-mir-23a "Leukemia, Myeloid" 20399246 the 23a cluster is the first downstream miRNA target implicated in regulating the development of myeloid versus lymphoid cells. -transcription factor target hsa-let-7a-1 Neoplasms [unspecific] 20404092 "let-7a:let-7a-d, let-7i, mir-15b-16-2, and mir-106b-25, are direct targets of E2F1 and E2F3 during G(1)/S and are repressed in E2F1/3-null cells" -transcription factor target hsa-let-7a-2 Neoplasms [unspecific] 20404092 "let-7a:let-7a-d, let-7i, mir-15b-16-2, and mir-106b-25, are direct targets of E2F1 and E2F3 during G(1)/S and are repressed in E2F1/3-null cells" -transcription factor target hsa-let-7a-3 Neoplasms [unspecific] 20404092 "let-7a:let-7a-d, let-7i, mir-15b-16-2, and mir-106b-25, are direct targets of E2F1 and E2F3 during G(1)/S and are repressed in E2F1/3-null cells" -transcription factor target hsa-let-7i Neoplasms [unspecific] 20404092 "let-7i:let-7a-d, let-7i, mir-15b-16-2, and mir-106b-25, are direct targets of E2F1 and E2F3 during G(1)/S and are repressed in E2F1/3-null cells" -transcription factor target hsa-mir-106b Neoplasms [unspecific] 20404092 "mir-106b-25:let-7a-d, let-7i, mir-15b-16-2, and mir-106b-25, are direct targets of E2F1 and E2F3 during G(1)/S and are repressed in E2F1/3-null cells" -transcription factor target hsa-mir-15b Neoplasms [unspecific] 20404092 "mir-15b-16-2:let-7a-d, let-7i, mir-15b-16-2, and mir-106b-25, are direct targets of E2F1 and E2F3 during G(1)/S and are repressed in E2F1/3-null cells" -transcription factor target hsa-mir-25 Neoplasms [unspecific] 20404092 "mir-106b-25:let-7a-d, let-7i, mir-15b-16-2, and mir-106b-25, are direct targets of E2F1 and E2F3 during G(1)/S and are repressed in E2F1/3-null cells" -transcription factor target hsa-mir-93 Neoplasms [unspecific] 20404092 "mir-106b-25:let-7a-d, let-7i, mir-15b-16-2, and mir-106b-25, are direct targets of E2F1 and E2F3 during G(1)/S and are repressed in E2F1/3-null cells" -transcription factor target hsa-mir-192 Renal Fibrosis 20488955 miR-192:miR-192 mediates TGF-beta/Smad3-driven renal fibrosis -transcription factor target hsa-mir-21 Heart Failure 20546595 We show that the transcription factor p53 piggy-backs onto NF-kappaB/RELA and utilizes the kappaB-motif at a cis-regulatory region to control mir-21 expression. -transcription factor target hsa-mir-10b Nasopharyngeal Neoplasms 20732742 MicroRNA-10b induced by Epstein-Barr virus-encoded latent membrane protein-1 promotes the metastasis of human nasopharyngeal carcinoma cells -transcription factor target hsa-mir-155 Pancreatic Neoplasms 20871480 miR-155:Human SMG-1 is Involved in Gemcitabine-Induced Primary microRNA-155/BIC Up-Regulation in Human Pancreatic Cancer PANC-1 Cells -transcription factor target hsa-mir-199b Heart Failure 21102440 "miR-199b is a direct calcineurin/NFAT target gene that increases in expression in mouse and human heart failure, and targets the nuclear NFAT kinase dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a (Dyrk1a)" -transcription factor target hsa-mir-221 Glioblastoma 21245048 NF-kB and c-Jun induce the expression of the oncogenic miR-221 and miR-222 in prostate carcinoma and glioblastoma cells. -transcription factor target hsa-mir-221 Prostate Neoplasms 21245048 NF-kB and c-Jun induce the expression of the oncogenic miR-221 and miR-222 in prostate carcinoma and glioblastoma cells. -transcription factor target hsa-mir-155 "Leukemia, Lymphocytic, Chronic, B-Cell" 21296997 MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia. -transcription factor target hsa-let-7a-2 Lung Neoplasms 21365266 "9-cis-RA, all-trans-RA,lithium chloride and CEBP might play important regulatory roles in let-7a2 gene expression in A549 cells" -transcription factor target hsa-mir-200a Lung Neoplasms 21403400 The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice. -transcription factor target hsa-mir-200b Lung Neoplasms 21403400 The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice. -transcription factor target hsa-mir-200c Lung Neoplasms 21403400 The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice. -transcription factor target hsa-mir-451a "Leukemia-Lymphoma, Adult T-Cell" 21464222 Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL. -transcription factor target hsa-mir-122 "Carcinoma, Hepatocellular" 21654638 MicroRNA122 is a key regulator of alpha-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma. -transcription factor target hsa-mir-222 Lung Neoplasms 21656127 High-mobility group A1 proteins enhance the expression of the oncogenic miR-222 in lung cancer cells. -transcription factor target hsa-mir-181a-2 "Carcinoma, Hepatocellular" 21711587 Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma. -transcription factor target hsa-mir-181b-1 "Carcinoma, Hepatocellular" 21711587 Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma. -transcription factor target hsa-mir-181b-2 "Carcinoma, Hepatocellular" 21711587 Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma. -transcription factor target hsa-mir-181c "Carcinoma, Hepatocellular" 21711587 Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma. -transcription factor target hsa-mir-181d "Carcinoma, Hepatocellular" 21711587 Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma. -transcription factor target hsa-mir-132 Myocardial Infarction 21868695 Transplantation of Human Pericyte Progenitor Cells Improves the Repair of Infarcted Heart Through Activation of an Angiogenic Program Involving Micro-RNA-132. -transcription factor target hsa-mir-135a-1 "Carcinoma, Hepatocellular" 21888875 MicroRNA-135a Contributes to the Development of Portal Vein Tumor Thrombus by Promoting Metastasis in Hepatocellular Carcinoma. -transcription factor target hsa-mir-135a-2 "Carcinoma, Hepatocellular" 21888875 MicroRNA-135a Contributes to the Development of Portal Vein Tumor Thrombus by Promoting Metastasis in Hepatocellular Carcinoma. -transcription factor target hsa-mir-125b-1 Hematologic Neoplasms 21903586 "Mir-125b, a target of CDX2, regulates cell differentiation through the repression of the core binding factor in hematopoietic malignancies." -transcription factor target hsa-mir-125b-2 Hematologic Neoplasms 21903586 "Mir-125b, a target of CDX2, regulates cell differentiation through the repression of the core binding factor in hematopoietic malignancies." -transcription factor target hsa-let-7a-1 "Carcinoma, Hepatocellular" 21903590 C-myc Inhibits the Transcription of the MicroRNA Cluster MC-let-7a-1~let-7d via a Non-Canonical E-box. -transcription factor target hsa-let-7d "Carcinoma, Hepatocellular" 21903590 C-myc Inhibits the Transcription of the MicroRNA Cluster MC-let-7a-1~let-7d via a Non-Canonical E-box. -transcription factor target hsa-let-7f-1 "Carcinoma, Hepatocellular" 21903590 C-myc Inhibits the Transcription of the MicroRNA Cluster MC-let-7a-1~let-7d via a Non-Canonical E-box. -transcription factor target hsa-mir-135b Lymphoma 22042699 miR-135b mediates NPM-ALK-driven oncogenicity and renders IL-17-producing immunophenotype to anaplastic large cell lymphoma. -transcription factor target hsa-mir-143 "Leukemia, Myeloid, Acute" 22093444 "miR-143 and miR-145 expression is significantly repressed in primary AML patient samples as compared to neutrophils of healthy donors. Further analysis revealed impaired neutrophil differentiation of APL cells upon inhibition of miR-145 expression. Lastly, we identified p73 as transcriptional regulator of miR-143/145 during neutrophil differentiation of APL cells. Our data suggest that low miR-145 levels in APL, possibly due to aberrant expression of p73 transcription factors, contribute to the differentiation block seen in this disease." -transcription factor target hsa-mir-145 "Leukemia, Myeloid, Acute" 22093444 "miR-143 and miR-145 expression is significantly repressed in primary AML patient samples as compared to neutrophils of healthy donors. Further analysis revealed impaired neutrophil differentiation of APL cells upon inhibition of miR-145 expression. Lastly, we identified p73 as transcriptional regulator of miR-143/145 during neutrophil differentiation of APL cells. Our data suggest that low miR-145 levels in APL, possibly due to aberrant expression of p73 transcription factors, contribute to the differentiation block seen in this disease." -transcription factor target hsa-mir-125b-1 Osteosarcoma 22093834 miR-125b suppresses the proliferation and migration of osteosarcoma cells through down-regulation of STAT3. -transcription factor target hsa-mir-125b-2 Osteosarcoma 22093834 miR-125b suppresses the proliferation and migration of osteosarcoma cells through down-regulation of STAT3. -transcription factor target hsa-mir-155 Inflammation 22170100 Interferon regulatory factor 3 inhibits astrocyte inflammatory gene expression through suppression of the proinflammatory miR-155 and miR-155*. -transcription factor target hsa-mir-224 "Carcinoma, Hepatocellular" 22178270 Transcriptional regulation of mir-224 upregulated in human HCCs by NFkB inflammatory pathways. -transcription factor target hsa-mir-23b Breast Neoplasms 22231442 "ERalpha downregulates miR-30a by binding to two specific sites proximal to the gene and thereby inhibiting pri-miR synthesis. On the other hand, the receptor promotes miR-23b, -27b and 24-1 accumulation in the cell by binding in close proximity of the corresponding gene cluster and preventing in situ the inhibitory effects of ER§Ø©ãon pri-miR maturation by the p68/DDX5-Drosha microprocessor complex." -transcription factor target hsa-mir-24-1 Breast Neoplasms 22231442 "ERalpha downregulates miR-30a by binding to two specific sites proximal to the gene and thereby inhibiting pri-miR synthesis. On the other hand, the receptor promotes miR-23b, -27b and 24-1 accumulation in the cell by binding in close proximity of the corresponding gene cluster and preventing in situ the inhibitory effects of ER§Ø©ãon pri-miR maturation by the p68/DDX5-Drosha microprocessor complex." -transcription factor target hsa-mir-27b Breast Neoplasms 22231442 "ERalpha downregulates miR-30a by binding to two specific sites proximal to the gene and thereby inhibiting pri-miR synthesis. On the other hand, the receptor promotes miR-23b, -27b and 24-1 accumulation in the cell by binding in close proximity of the corresponding gene cluster and preventing in situ the inhibitory effects of ER§Ø©ãon pri-miR maturation by the p68/DDX5-Drosha microprocessor complex." -transcription factor target hsa-mir-30a Breast Neoplasms 22231442 "ERalpha downregulates miR-30a by binding to two specific sites proximal to the gene and thereby inhibiting pri-miR synthesis. On the other hand, the receptor promotes miR-23b, -27b and 24-1 accumulation in the cell by binding in close proximity of the corresponding gene cluster and preventing in situ the inhibitory effects of ER§Ø©ãon pri-miR maturation by the p68/DDX5-Drosha microprocessor complex." -transcription factor target hsa-mir-29b-1 Lung Neoplasms 22249264 MicroRNA-29b is involved in the Src-ID1 signaling pathway and is dysregulated in human lung adenocarcinoma. -transcription factor target hsa-mir-29b-2 Lung Neoplasms 22249264 MicroRNA-29b is involved in the Src-ID1 signaling pathway and is dysregulated in human lung adenocarcinoma. -transcription factor target hsa-mir-10b Breast Neoplasms 22286762 Sulindac inhibits tumor cell invasion by suppressing NF-kB-mediated transcription of microRNAs. -transcription factor target hsa-mir-10b Colon Neoplasms 22286762 Sulindac inhibits tumor cell invasion by suppressing NF-kB-mediated transcription of microRNAs. -transcription factor target hsa-mir-17 Breast Neoplasms 22286762 Sulindac inhibits tumor cell invasion by suppressing NF-kB-mediated transcription of microRNAs. -transcription factor target hsa-mir-17 Colon Neoplasms 22286762 Sulindac inhibits tumor cell invasion by suppressing NF-kB-mediated transcription of microRNAs. -transcription factor target hsa-mir-21 Breast Neoplasms 22286762 Sulindac inhibits tumor cell invasion by suppressing NF-kB-mediated transcription of microRNAs. -transcription factor target hsa-mir-21 Colon Neoplasms 22286762 Sulindac inhibits tumor cell invasion by suppressing NF-kB-mediated transcription of microRNAs. -transcription factor target hsa-mir-9-1 Breast Neoplasms 22286762 Sulindac inhibits tumor cell invasion by suppressing NF-kB-mediated transcription of microRNAs. -transcription factor target hsa-mir-9-1 Colon Neoplasms 22286762 Sulindac inhibits tumor cell invasion by suppressing NF-kB-mediated transcription of microRNAs. -transcription factor target hsa-mir-9-2 Breast Neoplasms 22286762 Sulindac inhibits tumor cell invasion by suppressing NF-kB-mediated transcription of microRNAs. -transcription factor target hsa-mir-9-2 Colon Neoplasms 22286762 Sulindac inhibits tumor cell invasion by suppressing NF-kB-mediated transcription of microRNAs. -transcription factor target hsa-mir-9-3 Breast Neoplasms 22286762 Sulindac inhibits tumor cell invasion by suppressing NF-kB-mediated transcription of microRNAs. -transcription factor target hsa-mir-9-3 Colon Neoplasms 22286762 Sulindac inhibits tumor cell invasion by suppressing NF-kB-mediated transcription of microRNAs. -transcription factor target hsa-mir-200a Colorectal Carcinoma 22286765 SIX1-induced CDH1 repression and EMT in CRC cells were correlated at least in part with posttranscriptional ZEB1 activation and miR-200-family transcriptional repression. -transcription factor target hsa-mir-200b Colorectal Carcinoma 22286765 SIX1-induced CDH1 repression and EMT in CRC cells were correlated at least in part with posttranscriptional ZEB1 activation and miR-200-family transcriptional repression. -transcription factor target hsa-mir-200c Colorectal Carcinoma 22286765 SIX1-induced CDH1 repression and EMT in CRC cells were correlated at least in part with posttranscriptional ZEB1 activation and miR-200-family transcriptional repression. -transcription factor target hsa-mir-34a Esophageal Neoplasms 22292433 Transcriptional activation of microRNA-34a by NF-kappa B in human esophageal cancer cells. -transcription factor target hsa-mir-196b Gastric Neoplasms 22298639 miR-196b expression was significantly repressed by ETS2 during gastric cancer oncogenesis. -transcription factor target hsa-mir-199a-1 "Carcinoma, Hepatocellular" 22359598 ER Stress Negatively Modulates the Expression of the miR-199a/214 Cluster to Regulates Tumor Survival and Progression in Human Hepatocellular Cancer. -transcription factor target hsa-mir-199a-2 "Carcinoma, Hepatocellular" 22359598 ER Stress Negatively Modulates the Expression of the miR-199a/214 Cluster to Regulates Tumor Survival and Progression in Human Hepatocellular Cancer. -transcription factor target hsa-mir-214 "Carcinoma, Hepatocellular" 22359598 ER Stress Negatively Modulates the Expression of the miR-199a/214 Cluster to Regulates Tumor Survival and Progression in Human Hepatocellular Cancer. -transcription factor target hsa-let-7a-1 Breast Neoplasms 22388088 "SHP2 activated stemness-associated transcription factors, including v-myc myelocytomatosis viral oncogene homolog (c-Myc) and zinc finger E-box binding homeobox 1 (ZEB1), which resulted in the repression of let-7 microRNA and the expression of a set of 'SHP2 signature' genes." -transcription factor target hsa-let-7a-2 Breast Neoplasms 22388088 "SHP2 activated stemness-associated transcription factors, including v-myc myelocytomatosis viral oncogene homolog (c-Myc) and zinc finger E-box binding homeobox 1 (ZEB1), which resulted in the repression of let-7 microRNA and the expression of a set of 'SHP2 signature' genes." -transcription factor target hsa-let-7a-3 Breast Neoplasms 22388088 "SHP2 activated stemness-associated transcription factors, including v-myc myelocytomatosis viral oncogene homolog (c-Myc) and zinc finger E-box binding homeobox 1 (ZEB1), which resulted in the repression of let-7 microRNA and the expression of a set of 'SHP2 signature' genes." -transcription factor target hsa-let-7b Breast Neoplasms 22388088 "SHP2 activated stemness-associated transcription factors, including v-myc myelocytomatosis viral oncogene homolog (c-Myc) and zinc finger E-box binding homeobox 1 (ZEB1), which resulted in the repression of let-7 microRNA and the expression of a set of 'SHP2 signature' genes." -transcription factor target hsa-let-7c Breast Neoplasms 22388088 "SHP2 activated stemness-associated transcription factors, including v-myc myelocytomatosis viral oncogene homolog (c-Myc) and zinc finger E-box binding homeobox 1 (ZEB1), which resulted in the repression of let-7 microRNA and the expression of a set of 'SHP2 signature' genes." -transcription factor target hsa-let-7d Breast Neoplasms 22388088 "SHP2 activated stemness-associated transcription factors, including v-myc myelocytomatosis viral oncogene homolog (c-Myc) and zinc finger E-box binding homeobox 1 (ZEB1), which resulted in the repression of let-7 microRNA and the expression of a set of 'SHP2 signature' genes." -transcription factor target hsa-let-7e Breast Neoplasms 22388088 "SHP2 activated stemness-associated transcription factors, including v-myc myelocytomatosis viral oncogene homolog (c-Myc) and zinc finger E-box binding homeobox 1 (ZEB1), which resulted in the repression of let-7 microRNA and the expression of a set of 'SHP2 signature' genes." -transcription factor target hsa-let-7f-1 Breast Neoplasms 22388088 "SHP2 activated stemness-associated transcription factors, including v-myc myelocytomatosis viral oncogene homolog (c-Myc) and zinc finger E-box binding homeobox 1 (ZEB1), which resulted in the repression of let-7 microRNA and the expression of a set of 'SHP2 signature' genes." -transcription factor target hsa-let-7f-2 Breast Neoplasms 22388088 "SHP2 activated stemness-associated transcription factors, including v-myc myelocytomatosis viral oncogene homolog (c-Myc) and zinc finger E-box binding homeobox 1 (ZEB1), which resulted in the repression of let-7 microRNA and the expression of a set of 'SHP2 signature' genes." -transcription factor target hsa-let-7g Breast Neoplasms 22388088 "SHP2 activated stemness-associated transcription factors, including v-myc myelocytomatosis viral oncogene homolog (c-Myc) and zinc finger E-box binding homeobox 1 (ZEB1), which resulted in the repression of let-7 microRNA and the expression of a set of 'SHP2 signature' genes." -transcription factor target hsa-let-7i Breast Neoplasms 22388088 "SHP2 activated stemness-associated transcription factors, including v-myc myelocytomatosis viral oncogene homolog (c-Myc) and zinc finger E-box binding homeobox 1 (ZEB1), which resulted in the repression of let-7 microRNA and the expression of a set of 'SHP2 signature' genes." -transcription factor target hsa-mir-155 Breast Neoplasms 22797073 Mutant p53 drives invasion in breast tumors through up-regulation of miR-155. -transcription factor target hsa-mir-302a Head And Neck Neoplasms 22847005 "Hyaluronan-CD44v3 interaction with Oct4/Sox2/Nanog promotes miR-302 expression leading to self-renewal, clonal formation and cisplatin resistance in cancer stem cells from head and neck squamous cell carcinoma." -transcription factor target hsa-mir-302b Head And Neck Neoplasms 22847005 "Hyaluronan-CD44v3 interaction with Oct4/Sox2/Nanog promotes miR-302 expression leading to self-renewal, clonal formation and cisplatin resistance in cancer stem cells from head and neck squamous cell carcinoma." -transcription factor target hsa-mir-302c Head And Neck Neoplasms 22847005 "Hyaluronan-CD44v3 interaction with Oct4/Sox2/Nanog promotes miR-302 expression leading to self-renewal, clonal formation and cisplatin resistance in cancer stem cells from head and neck squamous cell carcinoma." -transcription factor target hsa-mir-302d Head And Neck Neoplasms 22847005 "Hyaluronan-CD44v3 interaction with Oct4/Sox2/Nanog promotes miR-302 expression leading to self-renewal, clonal formation and cisplatin resistance in cancer stem cells from head and neck squamous cell carcinoma." -transcription factor target hsa-mir-302e Head And Neck Neoplasms 22847005 "Hyaluronan-CD44v3 interaction with Oct4/Sox2/Nanog promotes miR-302 expression leading to self-renewal, clonal formation and cisplatin resistance in cancer stem cells from head and neck squamous cell carcinoma." -transcription factor target hsa-mir-302f Head And Neck Neoplasms 22847005 "Hyaluronan-CD44v3 interaction with Oct4/Sox2/Nanog promotes miR-302 expression leading to self-renewal, clonal formation and cisplatin resistance in cancer stem cells from head and neck squamous cell carcinoma." -transcription factor target hsa-mir-29c Influenza 22850539 Induction of the cellular microRNA-29c by influenza virus contributes to virus-mediated apoptosis through repression of antiapoptotic factors BCL2L2. -transcription factor target hsa-mir-373 Cholangiocarcinoma 22876037 Mutual regulation between microRNA-373 and methyl-CpG-binding domain protein 2 in hilar cholangiocarcinoma. -transcription factor target hsa-mir-132 Prostate Neoplasms 22916239 Luteolin Induces microRNA-132 Expression and Modulates Neurite Outgrowth in PC12 Cells. -transcription factor target hsa-mir-9-1 Colon Neoplasms 23045246 Prospero homeobox 1 promotes epithelial-mesenchymal transition in colon cancer cells by inhibiting E-cadherin via miR-9 -transcription factor target hsa-mir-9-2 Colon Neoplasms 23045246 Prospero homeobox 1 promotes epithelial-mesenchymal transition in colon cancer cells by inhibiting E-cadherin via miR-9 -transcription factor target hsa-mir-720 Esophageal Neoplasms 23154181 SnoN/SKIL modulates proliferation through control of hsa-miR-720 transcription in esophageal cancer cells -transcription factor target hsa-mir-150 "Scleroderma, Systemic" 23159943 miR-150 Down-Regulation Contributes to the Constitutive Type I Collagen Overexpression in Scleroderma Dermal Fibroblasts via the Induction of Integrin §Ø©ã -transcription factor target hsa-mir-9-1 Glioma 23185366 The CREB-miR-9 negative feedback minicircuitry coordinates the migration and proliferation of glioma cells -transcription factor target hsa-mir-9-2 Glioma 23185366 The CREB-miR-9 negative feedback minicircuitry coordinates the migration and proliferation of glioma cells -transcription factor target hsa-mir-29b-1 Multiple Myeloma 23190608 miR-29b sensitizes multiple myeloma cells to bortezomib-induced apoptosis through the activation of a feedback loop with the transcription factor Sp1 -transcription factor target hsa-mir-29b-2 Multiple Myeloma 23190608 miR-29b sensitizes multiple myeloma cells to bortezomib-induced apoptosis through the activation of a feedback loop with the transcription factor Sp1 -transcription factor target hsa-mir-138-1 "Leukemia, Myeloid" 23208504 BCR-ABL/GATA1/miR-138 mini circuitry contributes to the leukemogenesis of chronic myeloid leukemia -transcription factor target hsa-mir-138-2 "Leukemia, Myeloid" 23208504 BCR-ABL/GATA1/miR-138 mini circuitry contributes to the leukemogenesis of chronic myeloid leukemia -transcription factor target hsa-mir-205 Urinary Bladder Cancer 23239884 The p63 isoform deltaNp63§Ø©ãinhibits epithelial-mesenchymal transition in human bladder cancer cells: Role of miR205 -transcription factor target hsa-mir-370 Neoplasms [unspecific] 23333300 Stat3 inhibits WTX expression through up-regulation of microRNA-370 in Wilms tumor -transcription factor target hsa-mir-21 Liver Neoplasms 23355454 microRNA 21-mediated suppression of Sprouty1 by Pokemon affects liver cancer cell growth and proliferation -transcription factor target hsa-mir-221 Melanoma 23400877 The abrogation of the HOXB7/PBX2 complex induces apoptosis in melanoma through the miR-221&222-c-FOS pathway -transcription factor target hsa-mir-222 Melanoma 23400877 The abrogation of the HOXB7/PBX2 complex induces apoptosis in melanoma through the miR-221&222-c-FOS pathway -transcription factor target hsa-mir-30d "Carcinoma, Renal Cell" 23416459 MiR-30d induces apoptosis and is regulated by the Akt/FOXO pathway in renal cell carcinoma -transcription factor target hsa-mir-203 Breast Neoplasms 23447531 Signaling between TGF-beta and Transcription factor SNAI2 Represses Expression of microRNA miR-203 to Promote Epithelial-Mesenchymal Transition and Tumor Metastasis -transcription factor target hsa-mir-125b-1 Prostate Neoplasms 23503464 Regulation of several androgen-induced genes through the repression of the miR-99a/let-7c/miR-125b-2 miRNA cluster in prostate cancer cells -transcription factor target hsa-mir-125b-2 Prostate Neoplasms 23503464 Regulation of several androgen-induced genes through the repression of the miR-99a/let-7c/miR-125b-2 miRNA cluster in prostate cancer cells -transcription factor target hsa-mir-99a Prostate Neoplasms 23503464 Regulation of several androgen-induced genes through the repression of the miR-99a/let-7c/miR-125b-2 miRNA cluster in prostate cancer cells -transcription factor target hsa-mir-125b-1 "Lymphoma, T-Cell" 23527180 cMyc/miR-125b-5p Signalling Determines Sensitivity to Bortezomib in Preclinical Model of Cutaneous T-Cell Lymphomas -transcription factor target hsa-mir-125b-2 "Lymphoma, T-Cell" 23527180 cMyc/miR-125b-5p Signalling Determines Sensitivity to Bortezomib in Preclinical Model of Cutaneous T-Cell Lymphomas -transcription factor target hsa-mir-191 Breast Neoplasms 23542418 "MicroRNA-191, an estrogen responsive microRNA, functions as an oncogenic regulator in human breast cancer" -transcription factor target hsa-mir-144 Alzheimer Disease 23546882 MicroRNA-144 Is Regulated by Activator Protein-1 (AP-1) and Decreases Expression of Alzheimer's Disease-related A Disintegrin And Metalloprotease 10 (ADAM10) -transcription factor target hsa-mir-506 Breast Neoplasms 23717581 miR-506 Regulates Epithelial Mesenchymal Transition in Breast Cancer Cell Lines. -transcription factor target hsa-mir-370 "Carcinoma, Hepatocellular" 23728999 Perturbation of miR-370-LIN28A-NF-¦ÊB regulatory circuit contributes to the development of hepatocellular carcinoma. -transcription factor target hsa-mir-155 "Leukemia, Lymphocytic, Chronic, B-Cell" 23750211 Signal Transducer and Activator of Transcription-3 Induces MicroRNA-155 Expression in Chronic Lymphocytic Leukemia. -transcription factor target hsa-mir-27a Breast Neoplasms 23752185 miR-27a regulates endothelial differentiation of breast cancer stem like cells. -transcription factor target hsa-mir-200a Neoplasms [unspecific] 23759590 KDM5B histone demethylase controls epithelial-mesenchymal transition of cancer cells by regulating the expression of the microRNA-200 family. -transcription factor target hsa-mir-200b Neoplasms [unspecific] 23759590 KDM5B histone demethylase controls epithelial-mesenchymal transition of cancer cells by regulating the expression of the microRNA-200 family. -transcription factor target hsa-mir-200c Neoplasms [unspecific] 23759590 KDM5B histone demethylase controls epithelial-mesenchymal transition of cancer cells by regulating the expression of the microRNA-200 family. -transcription factor target hsa-mir-127 "Carcinoma, Hepatocellular" 23762330 A Feedback Inhibition between miRNA-127 and TGFbeta/c-Jun Cascade in HCC Cell Migration via MMP13. -transcription factor target hsa-mir-199a-1 "Muscular Dystrophy, Duchenne" 23764775 "MicroRNA-199a is induced in dystrophic muscle and affects WNT signaling, cell proliferation, and myogenic differentiation." -transcription factor target hsa-mir-199a-2 "Muscular Dystrophy, Duchenne" 23764775 "MicroRNA-199a is induced in dystrophic muscle and affects WNT signaling, cell proliferation, and myogenic differentiation." -transcription factor target hsa-mir-134 "Carcinoma, Hepatocellular" 23775631 Hepatocyte nuclear factor-4¦Á reverses malignancy of hepatocellular carcinoma through regulating mir-134 in the DLK1-DIO3 region. -transcription factor target hsa-mir-373 Pancreatic Neoplasms 23857777 A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth. -transcription factor target hsa-mir-1 Neoplasms [unspecific] 23921124 Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis. -transcription factor target hsa-mir-206 Neoplasms [unspecific] 23921124 Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis. -transcription factor target hsa-mir-205 Prostate Neoplasms 23924028 The evidence that miR-205 replacement in PCa cells is able not only to prevent but also to revert the oxidative/pro-inflammatory axis leading to EMT induced by CAFs sets the rationale for developing miRNA-based approaches to prevent and treat metastatic disease. -transcription factor target hsa-mir-125b "Carcinoma, Cervical" 23928699 OCT4 promotes tumorigenesis and inhibits apoptosis of cervical cancer cells by miR-125b/BAK1 pathway. -transcription factor target hsa-mir-23a Gastrointestinal Neoplasms 23929433 miR-23a inhibits E-cadherin expression and is regulated by AP-1 and NFAT4 complex during Fas-induced EMT in gastrointestinal cancer. -transcription factor target hsa-mir-143 Neoplasms [unspecific] 23932921 DDX6 post-transcriptionally down-regulates miR-143/145 expression through host gene NCR143/145 in cancer cells. -transcription factor target hsa-mir-145 Neoplasms [unspecific] 23932921 DDX6 post-transcriptionally down-regulates miR-143/145 expression through host gene NCR143/145 in cancer cells. -transcription factor target hsa-mir-20b Breast Neoplasms 23945289 Crucial role for early growth response-1 in the transcriptional regulation of miR-20b in breast cancer. -transcription factor target hsa-mir-30c "Leukemia, Myeloid, Acute" 23974200 Transcription factor C/EBP¦Á-induced microRNA-30c inactivates Notch1 during granulopoiesis and is downregulated in acute myeloid leukemia. -transcription factor target hsa-mir-204 Diabetes Mellitus 23975026 The newly identified TXNIP-miR-204-MAFA-insulin pathway may contribute to diabetes progression and provides new insight into TXNIP function and microRNA biology in health and disease. -transcription factor target hsa-mir-141 Breast Neoplasms 23975430 Significance of PELP1/HDAC2/miR-200 regulatory network in EMT and metastasis of breast cancer. -transcription factor target hsa-mir-200a Breast Neoplasms 23975430 Significance of PELP1/HDAC2/miR-200 regulatory network in EMT and metastasis of breast cancer. -transcription factor target hsa-mir-224 "Carcinoma, Hepatocellular" 23988648 miR-224 is critical for celastrol-induced inhibition of migration and invasion of hepatocellular carcinoma cells. -transcription factor target hsa-mir-198 Pancreatic Neoplasms 23989979 "miR-198 acts as a central tumor suppressor and modulates the molecular makeup of a critical interactome in pancreatic cancer, indicating a potential prognostic marker signature and the therapeutic potential of attacking this tumorigenic network through a central vantage point." -transcription factor target hsa-mir-122 "Carcinoma, Hepatocellular" 24038073 Reciprocal regulation of microRNA-122 and c-Myc in hepatocellular cancer: role of E2F1 and transcription factor dimerization partner 2. -transcription factor target hsa-mir-155 Breast Neoplasms 24080728 MicroRNA-155 broadly orchestrates inflammation-induced changes of microRNA expression in breast cancer -transcription factor target hsa-mir-26a Glioblastoma 24140063 C-Myc negatively controls the tumor suppressor PTEN by upregulating miR-26a in glioblastoma multiforme cells. -transcription factor target hsa-mir-203 "Carcinoma, Colon" 24145190 Maintenance of the stemness in CD44(+) HCT-15 and HCT-116 human colon cancer cells requires miR-203 suppression. -transcription factor target hsa-mir-365 Gastric Neoplasms 24149576 Akt-p53-miR-365-cyclin D1/cdc25A axis contributes to gastric tumorigenesis induced by PTEN deficiency. -transcription factor target hsa-mir-184 "Carcinoma, Nasopharyngeal" 24157866 Tumor suppressor PDCD4 modulates miR-184-mediated direct suppression of C-MYC and BCL2 blocking cell growth and survival in nasopharyngeal carcinoma. -transcription factor target hsa-mir-200c Prostate Neoplasms 24186205 TMPRSS2-ERG gene fusions induce prostate tumorigenesis by modulating microRNA miR-200c. -transcription factor target hsa-mir-548 "Lymphoma, Non-Hodgkin" 24216476 A microenvironment-mediated c-Myc/miR-548m/HDAC6 amplification loop in non-Hodgkin B cell lymphomas. -transcription factor target hsa-mir-183 Neoplasms [unspecific] 24277930 A p21-ZEB1 complex inhibits epithelial-mesenchymal transition through the microRNA 183-96-182 cluster. -transcription factor target hsa-mir-15a Colorectal Carcinoma 24285725 p53-induced miR-15a/16-1 and AP4 form a double-negative feedback loop to regulate epithelial-mesenchymal transition and metastasis in colorectal cancer. -transcription factor target hsa-mir-16-1 Colorectal Carcinoma 24285725 p53-induced miR-15a/16-1 and AP4 form a double-negative feedback loop to regulate epithelial-mesenchymal transition and metastasis in colorectal cancer. -transcription factor target hsa-mir-106b Breast Neoplasms 24292682 high level of miR-106b induced by TGF-¦Â determines the tumor-promoting effects of TGF-¦Â in breast cancer. -transcription factor target hsa-mir-221 Glioblastoma 24295494 miR-221/222 confers radioresistance in glioblastoma cells through activating Akt independent of PTEN status. -transcription factor target hsa-mir-222 Glioblastoma 24295494 miR-221/222 confers radioresistance in glioblastoma cells through activating Akt independent of PTEN status. -transcription factor target hsa-mir-183 Gastric Neoplasms 24335145 Glycogen synthase kinase 3 beta inhibits microRNA-183-96-182 cluster via the ¦Â-Catenin/TCF/LEF-1 pathway in gastric cancer cells. -transcription factor target hsa-mir-96 Gastric Neoplasms 24335145 Glycogen synthase kinase 3 beta inhibits microRNA-183-96-182 cluster via the ¦Â-Catenin/TCF/LEF-1 pathway in gastric cancer cells. -transcription factor target hsa-mir-17 Cardiovascular Diseases [unspecific] 24378993 Crosstalk between TGF-¦Â/Smad3 and BMP/BMPR2 signaling pathways via miR-17-92 cluster in carotid artery restenosis. -transcription factor target hsa-mir-18 Cardiovascular Diseases [unspecific] 24378993 Crosstalk between TGF-¦Â/Smad3 and BMP/BMPR2 signaling pathways via miR-17-92 cluster in carotid artery restenosis. -transcription factor target hsa-mir-19a Cardiovascular Diseases [unspecific] 24378993 Crosstalk between TGF-¦Â/Smad3 and BMP/BMPR2 signaling pathways via miR-17-92 cluster in carotid artery restenosis. -transcription factor target hsa-mir-19b-1 Cardiovascular Diseases [unspecific] 24378993 Crosstalk between TGF-¦Â/Smad3 and BMP/BMPR2 signaling pathways via miR-17-92 cluster in carotid artery restenosis. -transcription factor target hsa-mir-20a Cardiovascular Diseases [unspecific] 24378993 Crosstalk between TGF-¦Â/Smad3 and BMP/BMPR2 signaling pathways via miR-17-92 cluster in carotid artery restenosis. -transcription factor target hsa-mir-92-1 Cardiovascular Diseases [unspecific] 24378993 Crosstalk between TGF-¦Â/Smad3 and BMP/BMPR2 signaling pathways via miR-17-92 cluster in carotid artery restenosis. -transcription factor target hsa-mir-199a Testicular Germ Cell Tumor 24391856 Molecular mechanisms of regulation and action of microRNA-199a in testicular germ cell tumor and glioblastomas. -transcription factor target hsa-mir-134 Glioblastoma 24440911 "Multiple receptor tyrosine kinases converge on microRNA-134 to control KRAS,STAT5B, and glioblastoma." -transcription factor target hsa-mir-320a Colorectal Carcinoma 24454819 E2A predicts prognosis of colorectal cancer patients and regulates cancer cell growth by targeting miR-320a. -transcription factor target hsa-mir-145 "Diabetes Mellitus, Type 2" 24548410 miR-145 plays a role in the development of resistin-induced insulin resistance via the p65 pathway. -transcription factor target hsa-mir-146a Colorectal Carcinoma 24561623 MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells. -transcription factor target hsa-mir-31 Breast Neoplasms 24582497 The breast cancer oncogene EMSY represses transcription of antimetastatic microRNA miR-31. -transcription factor target hsa-mir-100 Neoplasms [unspecific] 24586203 "miR-100 induces epithelial-mesenchymal transition but suppresses tumorigenesis, migration and invasion." -transcription factor target hsa-mir-146b "Carcinoma, Esophageal" 24589738 Transcriptional regulation of miR-146b by C/EBP¦Â LAP2 in esophageal cancer cells. -transcription factor target hsa-mir-26a Idiopathic Pulmonary Fibrosis 24594795 The antifibrotic effects and mechanisms of microRNA-26a action in idiopathic pulmonary fibrosis. -transcription factor target hsa-mir-204 "Carcinoma, Nasopharyngeal" 24613926 Down-regulation of miRNA-204 by LMP-1 enhances CDC42 activity and facilitates invasion of EBV-associated nasopharyngeal carcinoma cells. -transcription factor target hsa-mir-124 Colorectal Carcinoma 24619225 The pro-apoptotic role of the regulatory feedback loop between miR-124 and PKM1/HNF4¦Á in colorectal cancer cells. -transcription factor target hsa-mir-145 Colorectal Carcinoma 24631504 Peroxisome proliferator-activated receptor ¦Ã-mediated induction of microRNA-145 opposes tumor phenotype in colorectal cancer. -transcription factor target hsa-mir-34a Colorectal Carcinoma 24642471 IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. -transcription factor target hsa-mir-29 "Diabetes Mellitus, Type 2" 24722248 MicroRNA-29 fine-tunes the expression of key FOXA2-activated lipid metabolism genes and is dysregulated in animal models of insulin resistance and diabetes. -transcription factor target hsa-mir-223 "Leukemia, Lymphoblastic, Acute, T-Cell" 24727676 Notch and NF-kB signaling pathways regulate miR-223/FBXW7 axis in T-cell acute lymphoblastic leukemia. -transcription factor target hsa-mir-210 Melanoma 24767210 Distinct microRNA expression signatures are associated with melanoma subtypes and are regulated by HIF1A. -transcription factor target hsa-mir-218 Melanoma 24767210 Distinct microRNA expression signatures are associated with melanoma subtypes and are regulated by HIF1A. -transcription factor target hsa-mir-224 Melanoma 24767210 Distinct microRNA expression signatures are associated with melanoma subtypes and are regulated by HIF1A. -transcription factor target hsa-mir-452 Melanoma 24767210 Distinct microRNA expression signatures are associated with melanoma subtypes and are regulated by HIF1A. -transcription factor target hsa-mir-181c Hepatitis C Virus Infection 24789793 Transcriptional suppression of miR-181c by hepatitis C virus enhances homeobox A1 expression. -transcription factor target hsa-mir-200b "Adenocarcinoma, Lung" 24830600 the HDAC1/4/Sp1/miR-200b/E2F3 pathway is responsible for chemoresistance of docetaxel-resistant LAD cells. -transcription factor target hsa-mir-28 "Lymphoma, B-Cell" 24843176 MicroRNA 28 controls cell proliferation and is down-regulated in B-cell lymphomas. -transcription factor target hsa-mir-509 "Carcinoma, Hepatocellular" 24882622 The oncoprotein HBXIP up-regulates SCG3 through modulating E2F1 and miR-509-3p in hepatoma cells. -transcription factor target hsa-mir-210 Idiopathic Pulmonary Fibrosis 24951777 miR-210 promotes IPF fibroblast proliferation in response to hypoxia. -transcription factor target hsa-mir-128 Glioma 24959930 "An axis involving SNAI1, microRNA-128 and SP1 modulates glioma progression." -transcription factor target hsa-mir-21 Myocardial Ischemic-Reperfusion Injury 24983504 A feedback regulatory loop between HIF-1¦Á and miR-21 in response to hypoxia in cardiomyocytes. -transcription factor target hsa-mir-203 "Squamous Cell Carcinoma, Esophageal" 24994936 EGF-induced C/EBP¦Â participates in EMT by decreasing the expression of miR-203 in esophageal squamous cell carcinoma cells. -transcription factor target hsa-mir-199a Gastric Neoplasms 25080937 SRF expedites metastasis and modulates the epithelial to mesenchymal transition by regulating miR-199a-5p expression in human gastric cancer. -transcription factor target hsa-mir-21 "Carcinoma, Hepatocellular" 25087183 Hepatitis B virus X protein promotes hepatocellular carcinoma transformation through interleukin-6 activation of microRNA-21 expression. -transcription factor target hsa-mir-155 "Leukemia, Myeloid, Acute" 25092123 LIFR¦Á-CT3 induces differentiation of a human acute myelogenous leukemia cell line HL-60 by suppressing miR-155 expression through the JAK/STAT pathway. -transcription factor target hsa-mir-191 Pancreatic Neoplasms 25119596 The clinical significance and regulation mechanism of hypoxia-inducible factor-1 and miR-191 expression in pancreatic cancer. -transcription factor target hsa-mir-9 MELAS Syndrome 25149473 The ROS-sensitive microRNA-9/9* controls the expression of mitochondrial tRNA-modifying enzymes and is involved in the molecular mechanism of MELAS syndrome. -transcription factor target hsa-mir-590 Breast Neoplasms 25150595 A feedback expression of microRNA-590 and activating transcription factor-3 in human breast cancer cells. -transcription factor target hsa-mir-425 Gastric Neoplasms 25154996 There is a critical role for NF-kappa B-dependent up-regulation of miR-425. And it represents a new pathway for the repression of phosphatase and tensin homolog activation and the promotion of cell survival upon IL-1¦Â induction. -transcription factor target hsa-mir-31 "Carcinoma, Oral" 25229239 EGF up-regulates miR-31 through the C/EBP¦Â signal cascade in oral carcinoma. -transcription factor target hsa-mir-1 "Carcinoma, Nasopharyngeal" 25237831 EZH2 promotes angiogenesis through inhibition of miR-1/Endothelin-1 axis in nasopharyngeal carcinoma. -transcription factor target hsa-mir-200b "Adenocarcinoma, Lung" 25279705 Histone deacetylase 1/Sp1/microRNA-200b signaling accounts for maintenance of cancer stem-like cells in human lung adenocarcinoma. -transcription factor target hsa-mir-21 Glioma 25305446 Kr¨¹ppel-like factor 9 inhibits glioma cell proliferation and tumorigenicity via downregulation of miR-21. -transcription factor target hsa-mir-125b-1 "Leukemia, Myeloid, Acute" 25323587 NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival. -transcription factor target hsa-mir-29b-1 "Leukemia, Myeloid, Acute" 25323587 NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival. -transcription factor target hsa-mir-31 Prostate Neoplasms 25341040 Polycomb protein EZH2 suppresses apoptosis by silencing the proapoptotic miR-31. -transcription factor target hsa-mir-224 Melanoma 25341426 E2F1 induces miR-224/452 expression to drive EMT through TXNIP downregulation. -transcription factor target hsa-mir-452 Melanoma 25341426 E2F1 induces miR-224/452 expression to drive EMT through TXNIP downregulation. -transcription factor target hsa-mir-200 "Carcinoma, Colon" 25371200 MicroRNA-200 (miR-200) cluster regulation by achaete scute-like 2 (Ascl2): impact on the epithelial-mesenchymal transition in colon cancer cells. -transcription factor target hsa-mir-188 Alzheimer Disease 25378159 Synaptic and cognitive improvements by inhibition of 2-AG metabolism are through upregulation of microRNA-188-3p in a mouse model of Alzheimer's disease. -transcription factor target hsa-let-7c Breast Neoplasms 25388283 "HER2 protein expression and activity are negatively correlated with let-7c expression in TCGA. In summary, we identified an ER-regulated miRNA cluster that regulates HER2, is lost with progression to estrogen independence, and may serve as a biomarker of poor outcome in ER(+) luminal A breast cancer patients." -transcription factor target hsa-mir-125b Breast Neoplasms 25388283 "HER2 protein expression and activity are negatively correlated with let-7c expression in TCGA. In summary, we identified an ER-regulated miRNA cluster that regulates HER2, is lost with progression to estrogen independence, and may serve as a biomarker of poor outcome in ER(+) luminal A breast cancer patients." -transcription factor target hsa-mir-99a Breast Neoplasms 25388283 "HER2 protein expression and activity are negatively correlated with let-7c expression in TCGA. In summary, we identified an ER-regulated miRNA cluster that regulates HER2, is lost with progression to estrogen independence, and may serve as a biomarker of poor outcome in ER(+) luminal A breast cancer patients." -transcription factor target hsa-mir-182 Breast Neoplasms 25394902 The miR-183/-96/-182 cluster is up-regulated in most breast cancer. It functions as an oncogene in breast cancer as it increases cell proliferation and migration. -transcription factor target hsa-mir-183 Breast Neoplasms 25394902 The miR-183/-96/-182 cluster is up-regulated in most breast cancer. It functions as an oncogene in breast cancer as it increases cell proliferation and migration. -transcription factor target hsa-mir-96 Breast Neoplasms 25394902 The miR-183/-96/-182 cluster is up-regulated in most breast cancer. It functions as an oncogene in breast cancer as it increases cell proliferation and migration. -transcription factor target hsa-mir-648 Pulmonary Hypertension 25403488 These studies provide a novel link wherein PlGF-mediated downregulation of PAX5 attenuates miR-648 expression leading to increased ET-1 levels that are known to induce PHT in SCA. -transcription factor target hsa-mir-139 Gastric Neoplasms 25499265 "Given that miR-139 and Jun are deregulated in many cancers, our findings here might have broader implication in other types of human cancers" -transcription factor target hsa-mir-96 Prostate Neoplasms 25531317 a novel mechanism accounting for the TGF¦Â signaling and bone metastasis. -transcription factor target hsa-mir-17 "Leukemia, Myeloid, Acute" 25612891 the extent of KIT-induced proliferation itself can modulate myeloid differentiation of cells with wild type RUNX1 function. -transcription factor target hsa-mir-31 "Carcinoma, Esophageal" 25644061 SOX4 interacts with EZH2 and HDAC3 to suppress microRNA-31 in invasive esophageal cancer cells. -transcription factor target hsa-mir-638 Melanoma 25650662 miR-638 promotes melanoma metastasis and protects melanoma cells from apoptosis and autophagy. -transcription factor target hsa-mir-203 "Carcinoma, Cervical" 25658920 BANF1 is downregulated by IRF1-regulated microRNA-203 in cervical cancer. -transcription factor target hsa-mir-203 Helicobacter pylori Infection 25689935 Our results demonstrated that H. pylori infection induced hepatic insulin resistance by the c-Jun/miR-203/SOCS3 signaling pathway and provide possible implications with regard to resolving insulin resistance. -transcription factor target hsa-mir-148a Neoplasms [unspecific] 25703326 Regulatory circuit of PKM2/NF-¦ÊB/miR-148a/152-modulated tumor angiogenesis and cancer progression. -transcription factor target hsa-mir-152 Neoplasms [unspecific] 25703326 Regulatory circuit of PKM2/NF-¦ÊB/miR-148a/152-modulated tumor angiogenesis and cancer progression. -transcription factor target hsa-mir-146 Breast Neoplasms 25712342 FOXP3 Controls an miR-146/NF-¦ÊB Negative Feedback Loop That Inhibits Apoptosis in Breast Cancer Cells. -transcription factor target hsa-mir-31 "Carcinoma, Breast" 25737447 "These studies further suggest that manipulation of miR-31 expression can be used to modulate senescence-related pathological conditions such as cancer,and the aging process." -transcription factor target hsa-mir-100 "Carcinoma, Cervical" 25757558 "Transcriptional regulation of microRNA-100, -146a, and -150 genes by p53 and NF¦ÊB p65/RelA in mouse striatal STHdh(Q7)/ Hdh(Q7) cells and human cervical carcinoma HeLa cells." -transcription factor target hsa-mir-146a "Carcinoma, Cervical" 25757558 "Transcriptional regulation of microRNA-100, -146a, and -150 genes by p53 and NF¦ÊB p65/RelA in mouse striatal STHdh(Q7)/ Hdh(Q7) cells and human cervical carcinoma HeLa cells." -transcription factor target hsa-mir-150 "Carcinoma, Cervical" 25757558 "Transcriptional regulation of microRNA-100, -146a, and -150 genes by p53 and NF¦ÊB p65/RelA in mouse striatal STHdh(Q7)/ Hdh(Q7) cells and human cervical carcinoma HeLa cells." -transcription factor target hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 25799148 Modulation of the NF-¦ÊB/miR-21/PTEN pathway in NSCLC showed that inhibition of this pathway may increase cisplatin sensitivity. -transcription factor target hsa-mir-182 "Carcinoma, Hepatocellular" 25813403 Wnt/¦Â-Catenin activates MiR-183/96/182 expression in hepatocellular carcinoma that promotes cell invasion. -transcription factor target hsa-mir-183 "Carcinoma, Hepatocellular" 25813403 Wnt/¦Â-Catenin activates MiR-183/96/182 expression in hepatocellular carcinoma that promotes cell invasion. -transcription factor target hsa-mir-96 "Carcinoma, Hepatocellular" 25813403 Wnt/¦Â-Catenin activates MiR-183/96/182 expression in hepatocellular carcinoma that promotes cell invasion. -transcription factor target hsa-mir-210 Obesity 25833255 "Our data suggest that the inflammatory intrauterine environment associated with maternal obesity induces an NF¦ÊB1-mediated increase in miR-210 in a fetal sex-dependent manner, leading to inhibition of mitochondrial respiration and placental dysfunction in the placentas of female fetuses." -transcription factor target hsa-mir-191 Breast Neoplasms 25867965 HIF-inducible miR-191 promotes migration in breast cancer through complex regulation of TGF¦Â-signaling in hypoxic microenvironment. -transcription factor target hsa-mir-371 Colorectal Carcinoma 25868860 "The SOX17/miR-371-5p/SOX2 axis inhibits EMT, stem cell properties and metastasis in colorectal cancer." -transcription factor target hsa-mir-182 Breast Neoplasms 25873390 Autocrine/Paracrine Human Growth Hormone-stimulated MicroRNA 96-182-183 Cluster Promotes Epithelial-Mesenchymal Transition and Invasion in Breast Cancer. -transcription factor target hsa-mir-183 Breast Neoplasms 25873390 Autocrine/Paracrine Human Growth Hormone-stimulated MicroRNA 96-182-183 Cluster Promotes Epithelial-Mesenchymal Transition and Invasion in Breast Cancer. -transcription factor target hsa-mir-96 Breast Neoplasms 25873390 Autocrine/Paracrine Human Growth Hormone-stimulated MicroRNA 96-182-183 Cluster Promotes Epithelial-Mesenchymal Transition and Invasion in Breast Cancer. -transcription factor target hsa-mir-214 Sickle Cell Disease 25876995 Erythropoietin-mediated expression of placenta growth factor is regulated via activation of hypoxia-inducible factor-1¦Á and post-transcriptionally by miR-214 in sickle cell disease. -transcription factor target hsa-mir-494 Lymphoma 25907832 The PTEN-AKT-mTOR/RICTOR Pathway in Nasal Natural Killer Cell Lymphoma Is Activated by miR-494-3p via PTEN But Inhibited by miR-142-3p via RICTOR. -transcription factor target hsa-mir-593 "Squamous Cell Carcinoma, Tongue" 25912308 Mitochondrial fission determines cisplatin sensitivity in tongue squamous cell carcinoma through the BRCA1-miR-593-5p-MFF axis. -transcription factor target hsa-mir-124 "Lymphoma, B-Cell" 25915824 MicroRNA-124 links p53 to the NF-¦ÊB pathway in B-cell lymphomas. -transcription factor target hsa-mir-31 Breast Neoplasms 25927669 A novel mechanism of regulation of the anti-metastatic miR-31 by EMSY in breast cancer. -transcription factor target hsa-mir-451 Glioblastoma 25937278 "These findings uncover miR-451 as a major effector of glucose-regulated AMPK signaling, allowing tumor cell adaptation to variations in nutrient availability in the tumor microenvironment." -transcription factor target hsa-mir-218 Glioblastoma 25943352 Feedback circuitry between miR-218 repression and RTK activation in glioblastoma. -transcription factor target hsa-mir-125b Ovarian Neoplasms 25944662 PPAR¦Ã inhibits ovarian cancer cells proliferation through upregulation of miR-125b. -transcription factor target hsa-mir-30 Heart Failure 25950484 "we describe that DOX causes acute and sustained miR-30 downregulation in cardiomyocytes via GATA-6. miR-30 overexpression protects cardiac cells from DOX-induced apoptosis, and its maintenance represents a potential cardioprotective and anti-tumorigenic strategy for anthracyclines." -transcription factor target hsa-mir-200a Breast Neoplasms 25972084 "our results suggest that Restin inhibits EMT and tumor metastasis by controlling the expression of the tumor metastasis suppressor mir-200a/b via association with p73. Our findings not only establish a mechanistic link between Restin, EMT and tumor metastasis, but also provide strong evidence supporting the notion that MAGE Group II proteins may exert a tumor suppressive effect in vivo." -transcription factor target hsa-mir-200b Breast Neoplasms 25972084 "our results suggest that Restin inhibits EMT and tumor metastasis by controlling the expression of the tumor metastasis suppressor mir-200a/b via association with p73. Our findings not only establish a mechanistic link between Restin, EMT and tumor metastasis, but also provide strong evidence supporting the notion that MAGE Group II proteins may exert a tumor suppressive effect in vivo." -transcription factor target hsa-mir-125b "Leukemia, Myeloid, Acute" 25982911 The deregulated expression of miR-125b in acute myeloid leukemia is dependent on the transcription factor C/EBP¦Á. -transcription factor target hsa-mir-615 "Carcinoma, Hepatocellular" 25987019 PU.1 Is Identified as a Novel Metastasis Suppressor in Hepatocellular Carcinoma Regulating the miR-615-5p/IGF2 Axis. -transcription factor target hsa-mir-148a Obesity 26001136 "The results suggest that miR-148a is a biomarker of obesity in human subjects and mouse model, which represents a CREB-modulated miRNA that acts to repress Wnt1, thereby promoting adipocyte differentiation." -transcription factor target hsa-mir-34a Obesity 26036628 These data provide first in vitro and in vivo evidence for the leptin-antagonist potential of honokiol (HNK) revealing a crosstalk between HNK and miR34a and Wnt1-MTA1-¦Â-catenin axis. -transcription factor target hsa-mir-19a Pancreatic Neoplasms 26041879 Sp1-driven up-regulation of miR-19a decreases RHOB and promotes pancreatic cancer. -transcription factor target hsa-mir-23b "Carcinoma, Gastric" 26041881 The reciprocal regulation loop of Notch2 pathway and miR-23b in controlling gastric carcinogenesis. -transcription factor target hsa-mir-146a Leukemia 26045293 Differential hypoxic regulation of the microRNA-146a/CXCR4 pathway in normal and leukemic monocytic cells: impact on response to chemotherapy. -transcription factor target hsa-mir-1 Prostate Neoplasms 26071255 EGF Receptor Promotes Prostate Cancer Bone Metastasis by Downregulating miR-1 and Activating TWIST1. -transcription factor target hsa-mir-338 "Carcinoma, Hepatocellular" 26082033 Mineralocorticoid receptor suppresses cancer progression and the Warburg effect by modulating the miR-338-3p-PKLR axis in hepatocellular carcinoma. -transcription factor target hsa-mir-29 Human Immunodeficiency Virus Infection 26108174 IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection. -transcription factor target hsa-mir-155 Neoplasms [unspecific] 26156524 the losing equilibrium of the regulatory feedback loop between STAT1 and miR-155-5p influencing tumorigenesis. -transcription factor target hsa-mir-224 Lung Neoplasms 26187928 MicroRNA-224 promotes tumor progression in nonsmall cell lung cancer. -transcription factor target hsa-mir-29b Glaucoma 26191170 "This study suggests that TGF-¦Â2 has a time-effect relationship with Tenon's capsule fibroblasts proliferation from glaucoma patients, and it stimulates Tenon's capsule fibroblast proliferation via suppression of miR-29b expression regulated by Nrf2." -transcription factor target hsa-mir-373 Breast Neoplasms 26196741 MiR-373 drives the epithelial-to-mesenchymal transition and metastasis via the miR-373-TXNIP-HIF1¦Á-TWIST signaling axis in breast cancer. -transcription factor target hsa-mir-214 Liver Fibrosis 26229009 These findings reveal a unique function for cellular or exosomal Twist1 in CCN2-dependent fibrogenesis. -transcription factor target hsa-mir-182 Soft Tissue Sarcoma 26234681 these results suggest that sarcoma metastasis can be partially controlled through Pax7/MyoD-dependent activation of miR-182 and provide insight into the role that myogenic transcription factors have in sarcoma progression. -transcription factor target hsa-mir-22 Lymphoma 26244872 "Jak3, STAT3, and STAT5 inhibit expression of miR-22, a novel tumor suppressor microRNA, in cutaneous T-Cell lymphoma." -transcription factor target hsa-mir-150 "Lymphoma, Large-Cell, Anaplastic" 26258416 "our results suggest that hypomethylating drugs,alone or in combination with other agents, may benefit ALK(+) patients harboring tumors resistant to crizotinib and other anti-ALK tyrosine kinase inhibitors (TKIs). Moreover, these results support further work on miR-150 in these and other ALK(+) malignancies." -transcription factor target hsa-mir-130a Neoplasms [unspecific] 26272168 These findings reveal an evolutionarily conserved positive feedback mechanism underlying robustness of the Hippo pathway in size control and tumorigenesis. -transcription factor target hsa-mir-206 Muscle Diseases [unspecific] 26272918 MyoD transcription factor induces myogenesis by inhibiting Twist-1 through miR-206. -transcription factor target hsa-mir-27a Gastric Neoplasms 26292288 HIF-1¦Á Induces Multidrug Resistance in Gastric Cancer Cells by Inducing MiR-27a. -transcription factor target hsa-mir-140 Lung Fibrosis 26300493 "Using these models we showed that IR induces overexpression of Brca1, Nrf2 and miR-140 in lung tissue after irradiation. These data reveal a novel radioprotective mechanism in which IR promotes NRF2 nuclear translocation and subsequent activation of miR-140 transcription in HLFs." -transcription factor target hsa-mir-145 "Carcinoma, Renal Cell" 26304926 Androgen receptor (AR) suppresses miRNA-145 to promote renal cell carcinoma (RCC) progression independent of VHL status. -transcription factor target hsa-mir-143 Pulmonary Hypertension 26311719 "MiR-143-3p modulated both cellular and exosome-mediated responses in pulmonary vascular cells, whereas inhibition of miR-143-3p blocked experimental pulmonary hypertension. Taken together, these findings confirm an important role for the miR-143/145 cluster in PAH pathobiology." -transcription factor target hsa-mir-190a Prostate Neoplasms 26314494 "Taken together, our findings identified a biochemical and functional link between miR-190a with reduced expression in advanced prostate cancer, YB-1 and AR signaling in prostate cancer." -transcription factor target hsa-mir-128a Glioma 26324126 IDH1R132H decreases the proliferation of U87 glioma cells through upregulation of microRNA-128a. -transcription factor target hsa-mir-204 Lymphoma 26350953 "This study demonstrated that HIF-1¦Á-miR-204-BCL-2 pathway contributed to apoptosis of neuronal cells induced by hypoxia, which could potentially be exploited to prevent spinal cord ischemia-reperfusion injury." -transcription factor target hsa-mir-132 Breast Neoplasms 26377202 "Taken together, the findings provide the first evidences of the synergistic anti-metastatic properties of miR-212/132 cluster through suppression of SOX4. Also, current study suggest a new miRNA-based mechanism elucidating the anti-metastatic properties of Ahr agonists, suggesting possibility of using miR-212/132 to control metastasis in breast cancer patients." -transcription factor target hsa-mir-212 Breast Neoplasms 26377202 "Taken together, the findings provide the first evidences of the synergistic anti-metastatic properties of miR-212/132 cluster through suppression of SOX4. Also, current study suggest a new miRNA-based mechanism elucidating the anti-metastatic properties of Ahr agonists, suggesting possibility of using miR-212/132 to control metastasis in breast cancer patients." -transcription factor target hsa-mir-22 Emphysema 26437241 "Thus, miR-22 is a critical regulator of both emphysema and T(H)17 responses." -transcription factor target hsa-mir-129 Breast Neoplasms 26460733 "Thus,miR-129-5p down-regulation fosters EMT in breast cancer by increasing Twist1-Snail and activating a negative feedback loop." -transcription factor target hsa-mir-101 "Carcinoma, Hepatocellular" 26718325 These findings show that elevated EZH2 contributes to miR-101 deregulation in HCC and highlight the coordinated role of miR-101 and EZH2 in hepatocarcinogenesis. -transcription factor target hsa-mir-101-1 "Carcinoma, Hepatocellular" 26718325 These findings show that elevated EZH2 contributes to miR-101 deregulation in HCC and highlight the coordinated role of miR-101 and EZH2 in hepatocarcinogenesis. -transcription factor target hsa-mir-23b Multiple Myeloma 26771806 miR-23b/SP1/c-myc forms a feed-forward loop supporting multiple myeloma cell growth. -transcription factor target hsa-mir-124 "Carcinoma, Lung, Non-Small-Cell" 26818357 The feedback loop between miR-124 and TGF-¦Â pathway plays a significant role in non-small cell lung cancer metastasis. -transcription factor target hsa-mir-146a Inflammation 26855180 Super enhancers at the miR-146a and miR-155 genes contribute to self-regulation of inflammation. -transcription factor target hsa-mir-155 Inflammation 26855180 Super enhancers at the miR-146a and miR-155 genes contribute to self-regulation of inflammation. -transcription factor target hsa-mir-130b "Carcinoma, Colon" 27082112 The infinity software that we have developed is a powerful tool to underscore new TF/miRNA regulatory networks. -transcription factor target hsa-mir-17 "Carcinoma, Colon" 27082112 The infinity software that we have developed is a powerful tool to underscore new TF/miRNA regulatory networks. -transcription factor target hsa-mir-181b "Carcinoma, Colon" 27082112 The infinity software that we have developed is a powerful tool to underscore new TF/miRNA regulatory networks. -transcription factor target hsa-mir-21 "Carcinoma, Colon" 27082112 The infinity software that we have developed is a powerful tool to underscore new TF/miRNA regulatory networks. -transcription factor target hsa-mir-301b "Carcinoma, Colon" 27082112 The infinity software that we have developed is a powerful tool to underscore new TF/miRNA regulatory networks. -transcription factor target hsa-mir-195 "Carcinoma, Hepatocellular" 27179445 Expression of microRNA-195 is transactivated by Sp1 but inhibited by histone deacetylase 3 in hepatocellular carcinoma cells. -tissue_expression_down hsa-mir-125a Breast Neoplasms 16103053 downregulation -tissue_expression_down hsa-mir-125b-1 Breast Neoplasms 16103053 downregulation -tissue_expression_down hsa-mir-125b-2 Breast Neoplasms 16103053 downregulation -tissue_expression_down hsa-mir-145 Breast Neoplasms 16103053 downregulation -tissue_expression_down hsa-mir-125a "Carcinoma, Hepatocellular" 16331254 downregulated -tissue_expression_down hsa-mir-126 Hepatitis C Virus Infection 16331254 downregulated -tissue_expression_down hsa-mir-143 Hepatitis C Virus Infection 16331254 downregulated -tissue_expression_down hsa-mir-195 "Carcinoma, Hepatocellular" 16331254 downregulated -tissue_expression_down hsa-mir-199a-1 "Carcinoma, Hepatocellular" 16331254 downregulated -tissue_expression_down hsa-mir-199a-1 Hepatitis C Virus Infection 16331254 downregulated -tissue_expression_down hsa-mir-199a-2 "Carcinoma, Hepatocellular" 16331254 downregulated -tissue_expression_down hsa-mir-199a-2 Hepatitis C Virus Infection 16331254 downregulated -tissue_expression_down hsa-mir-200a "Carcinoma, Hepatocellular" 16331254 downregulated -tissue_expression_down hsa-mir-28 Hepatitis C Virus Infection 16331254 downregulated -tissue_expression_down hsa-mir-342 Hepatitis C Virus Infection 16331254 downregulated -tissue_expression_down hsa-mir-372 Hepatitis C Virus Infection 16331254 downregulated -tissue_expression_down hsa-mir-376c Hepatitis C Virus Infection 16331254 downregulated -tissue_expression_down hsa-mir-101-1 Lung Neoplasms 16530703 downregulation -tissue_expression_down hsa-mir-125a Lung Neoplasms 16530703 downregulation -tissue_expression_down hsa-mir-126 Lung Neoplasms 16530703 downregulation -tissue_expression_down hsa-mir-140 Lung Neoplasms 16530703 downregulation -tissue_expression_down hsa-mir-143 Lung Neoplasms 16530703 downregulation -tissue_expression_down hsa-mir-145 Lung Neoplasms 16530703 downregulation -tissue_expression_down hsa-mir-181c Lung Neoplasms 16530703 downregulation -tissue_expression_down hsa-mir-192 Lung Neoplasms 16530703 mir-192-prec downregulation -tissue_expression_down hsa-mir-198 Lung Neoplasms 16530703 downregulation -tissue_expression_down hsa-mir-199b Lung Neoplasms 16530703 downregulation -tissue_expression_down hsa-mir-216a Lung Neoplasms 16530703 downregulation -tissue_expression_down hsa-mir-216b Lung Neoplasms 16530703 downregulation -tissue_expression_down hsa-mir-218-2 Lung Neoplasms 16530703 downregulation -tissue_expression_down hsa-mir-219-1 Lung Neoplasms 16530703 downregulation -tissue_expression_down hsa-mir-224 Lung Neoplasms 16530703 downregulation -tissue_expression_down hsa-mir-26a-1 Lung Neoplasms 16530703 downregulation -tissue_expression_down hsa-mir-27b Lung Neoplasms 16530703 downregulation -tissue_expression_down hsa-mir-29b-1 Lung Neoplasms 16530703 downregulation -tissue_expression_down hsa-mir-30a Lung Neoplasms 16530703 downregulation -tissue_expression_down hsa-mir-32 Lung Neoplasms 16530703 downregulation -tissue_expression_down hsa-mir-33a Lung Neoplasms 16530703 downregulation -tissue_expression_down hsa-mir-33b Lung Neoplasms 16530703 downregulation -tissue_expression_down hsa-mir-9-1 Lung Neoplasms 16530703 downregulation -tissue_expression_down hsa-mir-9-2 Lung Neoplasms 16530703 downregulation -tissue_expression_down hsa-mir-9-3 Lung Neoplasms 16530703 downregulation -tissue_expression_down hsa-mir-95 Lung Neoplasms 16530703 downregulation -tissue_expression_down hsa-mir-1 Vascular Hypertrophy 17008435 MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophy. -tissue_expression_down hsa-mir-133a Vascular Hypertrophy 17008435 MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophy. -tissue_expression_down hsa-let-7a-1 Neoplasms [unspecific] 17028596 "let-7a-1 downregulated in six solid cancer types by PAM and SAM (Volinia et al., 2006);" -tissue_expression_down hsa-let-7a-2 Breast Neoplasms 17028596 "let-7a-2, 7a-3, 7d, 7f-2 downregulated in breast cancer" -tissue_expression_down hsa-let-7a-2 Neoplasms [unspecific] 17028596 "Let-7/mir-98 expression is reduced in tumours, potentially contributing to elevated activity of the Ras pathway and effects on growth control." -tissue_expression_down hsa-let-7a-3 Breast Neoplasms 17028596 "let-7a-2, 7a-3, 7d, 7f-2 downregulated in breast cancer" -tissue_expression_down hsa-let-7a-3 Neoplasms [unspecific] 17028596 "Let-7/mir-98 expression is reduced in tumours, potentially contributing to elevated activity of the Ras pathway and effects on growth control." -tissue_expression_down hsa-let-7b Neoplasms [unspecific] 17028596 "Let-7/mir-98 expression is reduced in tumours, potentially contributing to elevated activity of the Ras pathway and effects on growth control." -tissue_expression_down hsa-let-7c Neoplasms [unspecific] 17028596 "Let-7/mir-98 expression is reduced in tumours, potentially contributing to elevated activity of the Ras pathway and effects on growth control." -tissue_expression_down hsa-let-7d Breast Neoplasms 17028596 "let-7a-2, 7a-3, 7d, 7f-2 downregulated in breast cancer" -tissue_expression_down hsa-let-7d Neoplasms [unspecific] 17028596 "Let-7/mir-98 expression is reduced in tumours, potentially contributing to elevated activity of the Ras pathway and effects on growth control." -tissue_expression_down hsa-let-7e Neoplasms [unspecific] 17028596 "Let-7/mir-98 expression is reduced in tumours, potentially contributing to elevated activity of the Ras pathway and effects on growth control." -tissue_expression_down hsa-let-7f-1 Neoplasms [unspecific] 17028596 "Let-7/mir-98 expression is reduced in tumours, potentially contributing to elevated activity of the Ras pathway and effects on growth control." -tissue_expression_down hsa-let-7f-2 Breast Neoplasms 17028596 "let-7a-2, 7a-3, 7d, 7f-2 downregulated in breast cancer" -tissue_expression_down hsa-let-7f-2 Neoplasms [unspecific] 17028596 "Let-7/mir-98 expression is reduced in tumours, potentially contributing to elevated activity of the Ras pathway and effects on growth control." -tissue_expression_down hsa-let-7g Neoplasms [unspecific] 17028596 "Let-7/mir-98 expression is reduced in tumours, potentially contributing to elevated activity of the Ras pathway and effects on growth control." -tissue_expression_down hsa-let-7i Neoplasms [unspecific] 17028596 "Let-7/mir-98 expression is reduced in tumours, potentially contributing to elevated activity of the Ras pathway and effects on growth control." -tissue_expression_down hsa-mir-10b Breast Neoplasms 17028596 "mir-10b downregulated in breast cancer (Iorio et al., 2005);" -tissue_expression_down hsa-mir-124-1 Lung Neoplasms 17028596 "mir-124, mir-183, mir-223, mir-29 mir-124a-3 downregulated in lung cancer (Yanaihara et al., 2006);" -tissue_expression_down hsa-mir-124-2 Lung Neoplasms 17028596 "mir-124, mir-183, mir-223, mir-29 mir-124a-3 downregulated in lung cancer (Yanaihara et al., 2006);" -tissue_expression_down hsa-mir-124-3 Lung Neoplasms 17028596 "mir-124, mir-183, mir-223, mir-29 mir-124a-3 downregulated in lung cancer (Yanaihara et al., 2006);" -tissue_expression_down hsa-mir-125a Breast Neoplasms 17028596 "mir-125a, b1, b2 downregulated in breast cancer (Iorio et al., 2005);" -tissue_expression_down hsa-mir-125b-1 Breast Neoplasms 17028596 "mir-125a, b1, b2 downregulated in breast cancer (Iorio et al., 2005);" -tissue_expression_down hsa-mir-125b-2 Breast Neoplasms 17028596 "mir-125a, b1, b2 downregulated in breast cancer (Iorio et al., 2005);" -tissue_expression_down hsa-mir-145 Breast Neoplasms 17028596 "mir-145 downregulated in breast cancer (Iorio et al., 2005) and lung cancer and deleted in prostate cancer (Yanaihara et al., 2006);" -tissue_expression_down hsa-mir-145 Lung Neoplasms 17028596 "mir-145 downregulated in breast cancer (Iorio et al., 2005) and lung cancer and deleted in prostate cancer (Yanaihara et al., 2006);" -tissue_expression_down hsa-mir-145 Prostate Neoplasms 17028596 "mir-145 downregulated in breast cancer (Iorio et al., 2005) and lung cancer and deleted in prostate cancer (Yanaihara et al., 2006);" -tissue_expression_down hsa-mir-181c Lung Neoplasms 17028596 "mir-181c-prec downregulated in lung cancer (Yanaihara et al., 2006);" -tissue_expression_down hsa-mir-218-2 Lung Neoplasms 17028596 "mir-218-2 downregulated in lung cancer (Yanaihara et al., 2006)" -tissue_expression_down hsa-mir-223 Lung Neoplasms 17028596 "mir-124, mir-183, mir-223, mir-29 mir-124a-3 downregulated in lung cancer (Yanaihara et al., 2006);" -tissue_expression_down hsa-mir-26a-1 Lung Neoplasms 17028596 "mir-26a-1-prec downregulated in lung cancer, deleted in epithelial cancers (Yanaihara et al., 2006)" -tissue_expression_down hsa-mir-29a Lung Neoplasms 17028596 "mir-124, mir-183, mir-223, mir-29 mir-124a-3 downregulated in lung cancer (Yanaihara et al., 2006);" -tissue_expression_down hsa-mir-29b-1 Lung Neoplasms 17028596 "mir-124, mir-183, mir-223, mir-29 mir-124a-3 downregulated in lung cancer (Yanaihara et al., 2006);" -tissue_expression_down hsa-mir-29b-2 Lung Neoplasms 17028596 "mir-124, mir-183, mir-223, mir-29 mir-124a-3 downregulated in lung cancer (Yanaihara et al., 2006);" -tissue_expression_down hsa-mir-29c Lung Neoplasms 17028596 "mir-124, mir-183, mir-223, mir-29 mir-124a-3 downregulated in lung cancer (Yanaihara et al., 2006);" -tissue_expression_down hsa-mir-30a Lung Neoplasms 17028596 "mir-30a-5p downregulated in lung cancer (Yanaihara et al., 2006);" -tissue_expression_down hsa-mir-30b Lung Neoplasms 17028596 "mir-30, mir-34 mir-30a-5p downregulated in lung cancer (Yanaihara et al., 2006)" -tissue_expression_down hsa-mir-30c-1 Lung Neoplasms 17028596 "mir-30, mir-34 mir-30a-5p downregulated in lung cancer (Yanaihara et al., 2006)" -tissue_expression_down hsa-mir-30c-2 Lung Neoplasms 17028596 "mir-30, mir-34 mir-30a-5p downregulated in lung cancer (Yanaihara et al., 2006)" -tissue_expression_down hsa-mir-30d Lung Neoplasms 17028596 "mir-30, mir-34 mir-30a-5p downregulated in lung cancer (Yanaihara et al., 2006)" -tissue_expression_down hsa-mir-30d Neoplasms [unspecific] 17028596 "mir-30d downregulated in six solid cancer types by SAM (Volinia et al., 2006);" -tissue_expression_down hsa-mir-30e Lung Neoplasms 17028596 "mir-30, mir-34 mir-30a-5p downregulated in lung cancer (Yanaihara et al., 2006)" -tissue_expression_down hsa-mir-32 Lung Neoplasms 17028596 "mir-32 downregulated in lung cancer (Yanaihara et al., 2006);" -tissue_expression_down hsa-mir-34a Breast Neoplasms 17028596 "mir-34 downregulated in breast cancer (Iorio et al., 2005)" -tissue_expression_down hsa-mir-34a Lung Neoplasms 17028596 "mir-30, mir-34 mir-30a-5p downregulated in lung cancer (Yanaihara et al., 2006)" -tissue_expression_down hsa-mir-34b Breast Neoplasms 17028596 "mir-34 downregulated in breast cancer (Iorio et al., 2005)" -tissue_expression_down hsa-mir-34b Lung Neoplasms 17028596 "mir-30, mir-34 mir-30a-5p downregulated in lung cancer (Yanaihara et al., 2006)" -tissue_expression_down hsa-mir-34c Breast Neoplasms 17028596 "mir-34 downregulated in breast cancer (Iorio et al., 2005)" -tissue_expression_down hsa-mir-34c Lung Neoplasms 17028596 "mir-30, mir-34 mir-30a-5p downregulated in lung cancer (Yanaihara et al., 2006)" -tissue_expression_down hsa-mir-92a-1 Neoplasms [unspecific] 17028596 "mir-92 downregulated in six solid cancer types by PAM (Volinia et al., 2006)" -tissue_expression_down hsa-mir-92a-2 Neoplasms [unspecific] 17028596 "mir-92 downregulated in six solid cancer types by PAM (Volinia et al., 2006)" -tissue_expression_down hsa-mir-92b Neoplasms [unspecific] 17028596 "mir-92 downregulated in six solid cancer types by PAM (Volinia et al., 2006)" -tissue_expression_down hsa-mir-98 Neoplasms [unspecific] 17028596 "Let-7/mir-98 expression is reduced in tumours, potentially contributing to elevated activity of the Ras pathway and effects on growth control." -tissue_expression_down hsa-mir-150 "Cardiomyopathy, Hypertrophic" 17108080 downregulated -tissue_expression_down hsa-mir-181b-1 "Cardiomyopathy, Hypertrophic" 17108080 downregulated -tissue_expression_down hsa-mir-181b-2 "Cardiomyopathy, Hypertrophic" 17108080 downregulated -tissue_expression_down hsa-mir-133a "Adenocarcinoma, Pancreatic Ductal" 17237814 The expression of miR-216 and -217 and lack of expression of miR-133a were identified as characteristic of pancreas tissue. -tissue_expression_down hsa-mir-195 Schizophrenia 17326821 downregulation -tissue_expression_down hsa-mir-20b Schizophrenia 17326821 downregulation -tissue_expression_down hsa-mir-212 Schizophrenia 17326821 downregulation -tissue_expression_down hsa-mir-24-1 Schizophrenia 17326821 downregulation -tissue_expression_down hsa-mir-24-2 Schizophrenia 17326821 downregulation -tissue_expression_down hsa-mir-26b Schizophrenia 17326821 downregulation -tissue_expression_down hsa-mir-29a Schizophrenia 17326821 downregulation -tissue_expression_down hsa-mir-29b-1 Schizophrenia 17326821 downregulation -tissue_expression_down hsa-mir-29c Schizophrenia 17326821 downregulation -tissue_expression_down hsa-mir-30a Schizophrenia 17326821 downregulation -tissue_expression_down hsa-mir-30b Schizophrenia 17326821 downregulation -tissue_expression_down hsa-mir-30d Schizophrenia 17326821 downregulation -tissue_expression_down hsa-mir-30e Schizophrenia 17326821 downregulation -tissue_expression_down hsa-mir-7-1 Schizophrenia 17326821 downregulation -tissue_expression_down hsa-mir-7-2 Schizophrenia 17326821 downregulation -tissue_expression_down hsa-mir-7-3 Schizophrenia 17326821 downregulation -tissue_expression_down hsa-mir-9-1 Schizophrenia 17326821 downregulation -tissue_expression_down hsa-mir-9-2 Schizophrenia 17326821 downregulation -tissue_expression_down hsa-mir-92a-1 Schizophrenia 17326821 downregulation -tissue_expression_down hsa-mir-92a-2 Schizophrenia 17326821 downregulation -tissue_expression_down hsa-mir-92b Schizophrenia 17326821 downregulation -tissue_expression_down hsa-mir-9-3 Schizophrenia 17326821 downregulation -tissue_expression_down hsa-mir-16-1 Autoimmune Diseases [unspecific] 17351108 "New Zealand black (NZB) mice (NZB) tissue sourcesof RNA showed a decrease in miR-16 in the spleen; however, theNZB kidney was not decreased in miR-16 expression compared withthe control strain expression. In addition, the NZB-derivedmalignant B-cell line, LNC, had an even greater decreased expressionof miR-16 compared with C57Bl6 spleen." -tissue_expression_down hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 17351108 "New Zealand black (NZB) mice (NZB) tissue sourcesof RNA showed a decrease in miR-16 in the spleen; however, theNZB kidney was not decreased in miR-16 expression compared withthe control strain expression. In addition, the NZB-derivedmalignant B-cell line, LNC, had an even greater decreased expressionof miR-16 compared with C57Bl6 spleen." -tissue_expression_down hsa-mir-16-2 Autoimmune Diseases [unspecific] 17351108 "New Zealand black (NZB) mice (NZB) tissue sourcesof RNA showed a decrease in miR-16 in the spleen; however, theNZB kidney was not decreased in miR-16 expression compared withthe control strain expression. In addition, the NZB-derivedmalignant B-cell line, LNC, had an even greater decreased expressionof miR-16 compared with C57Bl6 spleen." -tissue_expression_down hsa-mir-16-2 "Leukemia, Lymphocytic, Chronic, B-Cell" 17351108 "New Zealand black (NZB) mice (NZB) tissue sourcesof RNA showed a decrease in miR-16 in the spleen; however, theNZB kidney was not decreased in miR-16 expression compared withthe control strain expression. In addition, the NZB-derivedmalignant B-cell line, LNC, had an even greater decreased expressionof miR-16 compared with C57Bl6 spleen." -tissue_expression_down hsa-mir-125b "Carcinoma, Thyroid, Anaplastic" 17563749 "The overexpression of these four miRs in two human ATC-derived cell lines suggests a critical role of miR-125b and miR-26a downregulation in thyroid carcinogenesis, since a cell growth inhibition was achieved." -tissue_expression_down hsa-mir-26a "Carcinoma, Thyroid, Anaplastic" 17563749 "The overexpression of these four miRs in two human ATC-derived cell lines suggests a critical role of miR-125b and miR-26a downregulation in thyroid carcinogenesis, since a cell growth inhibition was achieved." -tissue_expression_down hsa-mir-107 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-130b Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-135a-1 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-135a-2 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-136 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-148a Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-150 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-16-1 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-16-2 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-17 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-182 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-186 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-192 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-19b-1 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-19b-2 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-218-1 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-218-2 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-22 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-23b Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-24-1 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-24-2 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-27a Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-299 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-302b Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-302c Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-30a Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-30b Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-30c-1 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-30c-2 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-30e Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-325 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-339 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-342 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-452 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-494 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-497 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-499a Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-507 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-512-1 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-512-2 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-515-1 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-515-2 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-520a Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-520b Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-520d Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-520e Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-520f Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-520g Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-520h Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-523 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-526a-1 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-526a-2 Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-526b Heart Failure 17606841 downregulated -tissue_expression_down hsa-mir-125b-1 Atopic Dermatitis 17622355 The level of this miRNA significantly (p<0.001 for both) decreased both in psoriasis and atopic eczema. -tissue_expression_down hsa-mir-125b-1 Psoriasis 17622355 The level of this miRNA significantly (p<0.001 for both) decreased both in psoriasis and atopic eczema. -tissue_expression_down hsa-mir-125b-2 Atopic Dermatitis 17622355 The level of this miRNA significantly (p<0.001 for both) decreased both in psoriasis and atopic eczema. -tissue_expression_down hsa-mir-125b-2 Psoriasis 17622355 The level of this miRNA significantly (p<0.001 for both) decreased both in psoriasis and atopic eczema. -tissue_expression_down hsa-mir-125b-1 Ovarian Neoplasms 17875710 "The most significantly overexpressed miRNAs were miR-200a, miR-141, miR-200c, and miR-200b, whereas miR-199a, miR-140, miR-145, and miR-125b1 were among the most down-modulated miRNAs." -tissue_expression_down hsa-mir-1-1 Musculoskeletal Abnormalities [unspecific] 17917533 "Studies performed to determine whether skeletal muscle hypertrophy affects miRNA expression showed that miR-1 and miR-133 were decreased, suggesting that these muscle-specific miRNAs may contribute to regulating the initial response of skeletal muscle to functional overload." -tissue_expression_down hsa-mir-1-2 Musculoskeletal Abnormalities [unspecific] 17917533 "Studies performed to determine whether skeletal muscle hypertrophy affects miRNA expression showed that miR-1 and miR-133 were decreased, suggesting that these muscle-specific miRNAs may contribute to regulating the initial response of skeletal muscle to functional overload." -tissue_expression_down hsa-mir-133a-1 Musculoskeletal Abnormalities [unspecific] 17917533 "Studies performed to determine whether skeletal muscle hypertrophy affects miRNA expression showed that miR-1 and miR-133 were decreased, suggesting that these muscle-specific miRNAs may contribute to regulating the initial response of skeletal muscle to functional overload." -tissue_expression_down hsa-mir-133a-2 Musculoskeletal Abnormalities [unspecific] 17917533 "Studies performed to determine whether skeletal muscle hypertrophy affects miRNA expression showed that miR-1 and miR-133 were decreased, suggesting that these muscle-specific miRNAs may contribute to regulating the initial response of skeletal muscle to functional overload." -tissue_expression_down hsa-mir-206 Musculoskeletal Abnormalities [unspecific] 17917533 Studies to evaluate the role of miRNAs in muscular dystrophy showed a dramatic increase in miR-206 expression in the diaphragm of the mdx mouse. -tissue_expression_down hsa-let-7c "Carcinoma, Hepatocellular" 18006136 These mice do not exhibit downregulation of let-7c gene expression thus forming the basis for the resistance to hepatocellular carcinogenesis. -tissue_expression_down hsa-mir-1 Retinitis Pigmentosa 18034880 "Expression of miR-1 and miR-133 decreased by more than 2.5-fold (P < 0.001), whereas expression of miR-96 and miR-183 increased by more than 3-fold (P < 0.001) in Pro347Ser retinas, as validated by qPCR." -tissue_expression_down hsa-mir-133 Retinitis Pigmentosa 18034880 "Expression of miR-1 and miR-133 decreased by more than 2.5-fold (P < 0.001), whereas expression of miR-96 and miR-183 increased by more than 3-fold (P < 0.001) in Pro347Ser retinas, as validated by qPCR." -tissue_expression_down hsa-mir-143 "Carcinoma, Rectal" 18196926 "Expression levels of analyzed miRNAs significantly differed among tumors and adjacent non-tumor tissues: miR-21 (p = 0.0001) and miR-31 (p = 0.0006) were upregulated, and miR-143 (p = 0.011) and miR-145 (p = 0.003) were downregulated in tumors." -tissue_expression_down hsa-mir-145 "Carcinoma, Rectal" 18196926 "Expression levels of analyzed miRNAs significantly differed among tumors and adjacent non-tumor tissues: miR-21 (p = 0.0001) and miR-31 (p = 0.0006) were upregulated, and miR-143 (p = 0.011) and miR-145 (p = 0.003) were downregulated in tumors." -tissue_expression_down hsa-mir-107 Alzheimer Disease 18234899 downregulated -tissue_expression_down hsa-mir-145 "Carcinoma, Hepatocellular" 18307259 "miR-122, miR-100, and miR-10a were overexpressed whereas miR-198 and miR-145 were up to 5-fold down-regulated in hepatic tumors compared to normal liver parenchyma." -tissue_expression_down hsa-mir-198 "Carcinoma, Hepatocellular" 18307259 "miR-122, miR-100, and miR-10a were overexpressed whereas miR-198 and miR-145 were up to 5-fold down-regulated in hepatic tumors compared to normal liver parenchyma." -tissue_expression_down hsa-mir-96 "Carcinoma, Hepatocellular" 18433021 "miR-96 was overexpressed in HBV tumors, and miR-126* was down-regulated in alcohol-related hepatocellular carcinoma." -tissue_expression_down hsa-let-7b Ovarian Neoplasms 18451233 lower -tissue_expression_down hsa-mir-106a Retinal Neovascularization 18500251 decreased -tissue_expression_down hsa-mir-214 Retinal Neovascularization 18500251 decreased -tissue_expression_down hsa-mir-424 Retinal Neovascularization 18500251 decreased -tissue_expression_down hsa-mir-221 Ovarian Neoplasms 18560586 "we identify several miRNAs aberrantly expressed in human ovarian cancer tissues and cell lines. miR-221 stands out as a highly elevated miRNA in ovarian cancer, while miR-21 and several members of the let-7 family are found downregulated." -tissue_expression_down hsa-mir-126 Urinary Bladder Cancer 18596939 miR-126: downregulated -tissue_expression_down hsa-mir-143 Urinary Bladder Cancer 18596939 miR-143: downregulated -tissue_expression_down hsa-mir-145 Urinary Bladder Cancer 18596939 miR-145: downregulated -tissue_expression_down hsa-mir-15a "Carcinoma, Pancreatic" 18665421 "In addition, when analyzed according to specific cancer phenotypes, miR-15a and miR-16 show a significant downregulation in canine ductal carcinomas while miRsR-181b, -21, -29b, and let-7f show a significant upregulation in canine tubular papillary carcinomas." -tissue_expression_down hsa-mir-16 "Carcinoma, Pancreatic" 18665421 "In addition, when analyzed according to specific cancer phenotypes, miR-15a and miR-16 show a significant downregulation in canine ductal carcinomas while miRsR-181b, -21, -29b, and let-7f show a significant upregulation in canine tubular papillary carcinomas." -tissue_expression_down hsa-mir-499a Head And Neck Neoplasms 18798260 miR-499: underexpressed -tissue_expression_down hsa-let-7c "Lymphoma, Burkitt" 18802929 "In particular, down-regulation of hsa-let-7c was observed in BL cases, compared to normal controls." -tissue_expression_down hsa-mir-145 Prostate Neoplasms 18949015 miR-145: down-regulated -tissue_expression_down hsa-mir-221 Prostate Neoplasms 18949015 miR-221: down-regulated -tissue_expression_down hsa-mir-222 Prostate Neoplasms 18949015 miR-222: down-regulated -tissue_expression_down hsa-mir-23b Prostate Neoplasms 18949015 miR-23b: down-regulated -tissue_expression_down hsa-mir-127 Ovarian Neoplasms 18954897 miR-127: under-expression -tissue_expression_down hsa-mir-155 Ovarian Neoplasms 18954897 miR-155: under-expression -tissue_expression_down hsa-mir-99b Ovarian Neoplasms 18954897 miR-99b: under-expression -tissue_expression_down hsa-mir-31 Medulloblastoma 18973228 miR-31: downregulated in all MBs -tissue_expression_down hsa-mir-1-1 Heart Failure 19059107 miR-1: decreased expression -tissue_expression_down hsa-mir-1-2 Heart Failure 19059107 miR-1: decreased expression -tissue_expression_down hsa-mir-133a-1 Heart Failure 19059107 miR-133a: decreased expression -tissue_expression_down hsa-mir-133a-2 Heart Failure 19059107 miR-133a: decreased expression -tissue_expression_down hsa-mir-133b Heart Failure 19059107 miR-133b: decreased expression -tissue_expression_down hsa-mir-141 Endometriosis 19074548 miR-141: downregulated -tissue_expression_down hsa-mir-142 Endometriosis 19074548 miR-142-3p: downregulated -tissue_expression_down hsa-mir-196b Endometriosis 19074548 miR-196b: downregulated -tissue_expression_down hsa-mir-200a Endometriosis 19074548 miR-200a: downregulated -tissue_expression_down hsa-mir-200b Endometriosis 19074548 miR-200b: downregulated -tissue_expression_down hsa-mir-20a Endometriosis 19074548 miR-20a: downregulated -tissue_expression_down hsa-mir-34c Endometriosis 19074548 miR-34c: downregulated -tissue_expression_down hsa-mir-424 Endometriosis 19074548 miR-424: downregulated -tissue_expression_down hsa-mir-193b "Adenocarcinoma, Endometrial" 19077565 miR-193b: downregulated -tissue_expression_down hsa-mir-204 "Adenocarcinoma, Endometrial" 19077565 miR-204: downregulated -tissue_expression_down hsa-mir-99b "Adenocarcinoma, Endometrial" 19077565 miR-99b: downregulated -tissue_expression_down hsa-mir-129-1 Gastric Neoplasms 19148490 miR-129: downregulated in undifferentiated gastric cancer -tissue_expression_down hsa-mir-129-2 Gastric Neoplasms 19148490 miR-129: downregulated in undifferentiated gastric cancer -tissue_expression_down hsa-mir-148a Gastric Neoplasms 19148490 miR-148: downregulated in undifferentiated gastric cancer -tissue_expression_down hsa-mir-148b Gastric Neoplasms 19148490 miR-148: downregulated in undifferentiated gastric cancer -tissue_expression_down hsa-let-7a-1 Digestive System Neoplasms 19156147 let-7a: downregulation -tissue_expression_down hsa-let-7a-2 Digestive System Neoplasms 19156147 let-7a: downregulation -tissue_expression_down hsa-let-7a-3 Digestive System Neoplasms 19156147 let-7a: downregulation -tissue_expression_down hsa-let-7b Digestive System Neoplasms 19156147 let-7b: downregulation -tissue_expression_down hsa-let-7c Digestive System Neoplasms 19156147 let-7c: downregulation -tissue_expression_down hsa-let-7d Digestive System Neoplasms 19156147 let-7d: downregulation -tissue_expression_down hsa-let-7e Digestive System Neoplasms 19156147 let-7e: downregulation -tissue_expression_down hsa-let-7f-1 Digestive System Neoplasms 19156147 let-7f: downregulation -tissue_expression_down hsa-let-7f-2 Digestive System Neoplasms 19156147 let-7f: downregulation -tissue_expression_down hsa-let-7g Digestive System Neoplasms 19156147 let-7g: downregulation -tissue_expression_down hsa-let-7i Digestive System Neoplasms 19156147 let-7i: downregulation -tissue_expression_down hsa-mir-373 Prostate Neoplasms 19158933 "miR-373: MicroRNAs 373 and 520c Are Downregulated in Prostate Cancer, Suppress CD44" -tissue_expression_down hsa-mir-520c Prostate Neoplasms 19158933 "miR-520c: MicroRNAs 373 and 520c Are Downregulated in Prostate Cancer, Suppress CD44" -tissue_expression_down hsa-mir-181b-1 Astrocytoma 19159078 miR-181b: downregulation -tissue_expression_down hsa-mir-181b-2 Astrocytoma 19159078 miR-181b: downregulation -tissue_expression_down hsa-mir-143 Neoplasms [unspecific] 19175697 "The expression of a subset of miRs (e.g. miR-21 and miR-155) was found to be consistently up-regulated, whereas another subset of miRs (e.g.miR-143 and miR-145) was consistently down-regulated across different cancer types suggesting their involvement in regulating common cellular processes whose deregulation may lead to tumourigenesis." -tissue_expression_down hsa-mir-145 Neoplasms [unspecific] 19175697 "The expression of a subset of miRs (e.g. miR-21 and miR-155) was found to be consistently up-regulated, whereas another subset of miRs (e.g.miR-143 and miR-145) was consistently down-regulated across different cancer types suggesting their involvement in regulating common cellular processes whose deregulation may lead to tumourigenesis." -tissue_expression_down hsa-mir-133b Gastric Neoplasms 19175831 miR-133b: down-regulated -tissue_expression_down hsa-mir-139 Gastric Neoplasms 19175831 miR-139-5p: down-regulated -tissue_expression_down hsa-mir-195 Gastric Neoplasms 19175831 miR-195: down-regulated -tissue_expression_down hsa-mir-31 Gastric Neoplasms 19175831 miR-31: down-regulated -tissue_expression_down hsa-mir-378a Gastric Neoplasms 19175831 miR-378: down-regulated -tissue_expression_down hsa-mir-497 Gastric Neoplasms 19175831 miR-497: down-regulated -tissue_expression_down hsa-let-7d Head And Neck Neoplasms 19179615 let-7d: show lower expression levels relative to normal adjacent tissue -tissue_expression_down hsa-mir-1-1 Head And Neck Neoplasms 19179615 miR-1: show lower expression levels relative to normal adjacent tissue -tissue_expression_down hsa-mir-1-2 Head And Neck Neoplasms 19179615 miR-1: show lower expression levels relative to normal adjacent tissue -tissue_expression_down hsa-mir-133a-1 Head And Neck Neoplasms 19179615 miR-133a: show lower expression levels relative to normal adjacent tissue -tissue_expression_down hsa-mir-133a-2 Head And Neck Neoplasms 19179615 miR-133a: show lower expression levels relative to normal adjacent tissue -tissue_expression_down hsa-mir-205 Head And Neck Neoplasms 19179615 miR-205: show lower expression levels relative to normal adjacent tissue -tissue_expression_down hsa-mir-15a Hepatitis B Virus Infection 19187610 miR-15a: down-regulated -tissue_expression_down hsa-mir-141 "Carcinoma, Renal Cell" 19228262 miR-141: down-regulated in malignant cancer than non-malignant one -tissue_expression_down hsa-mir-200b "Carcinoma, Renal Cell" 19228262 miR-200b: down-regulated in malignant cancer than non-malignant one -tissue_expression_down hsa-mir-200c "Carcinoma, Renal Cell" 19228262 miR-200c: down-regulated in malignant cancer than non-malignant one -tissue_expression_down hsa-mir-363 "Carcinoma, Renal Cell" 19228262 miR-363: down-regulated in malignant cancer than non-malignant one -tissue_expression_down hsa-mir-429 "Carcinoma, Renal Cell" 19228262 miR-429: down-regulated in malignant cancer than non-malignant one -tissue_expression_down hsa-mir-514a-1 "Carcinoma, Renal Cell" 19228262 miR-514: down-regulated in malignant cancer than non-malignant one -tissue_expression_down hsa-mir-514a-2 "Carcinoma, Renal Cell" 19228262 miR-514: down-regulated in malignant cancer than non-malignant one -tissue_expression_down hsa-mir-514a-3 "Carcinoma, Renal Cell" 19228262 miR-514: down-regulated in malignant cancer than non-malignant one -tissue_expression_down hsa-mir-205 Breast Neoplasms 19238171 miR-205: Suppress cell growth and invasion by target ErbB3 and VEGF-A -tissue_expression_down hsa-let-7a-1 Kaposi Sarcoma 19252139 let-7a: down-regulated -tissue_expression_down hsa-let-7a-1 "Lymphoma, Primary Effusion" 19252139 let-7a: down-regulated -tissue_expression_down hsa-let-7a-2 Kaposi Sarcoma 19252139 let-7a: down-regulated -tissue_expression_down hsa-let-7a-2 "Lymphoma, Primary Effusion" 19252139 let-7a: down-regulated -tissue_expression_down hsa-let-7a-3 Kaposi Sarcoma 19252139 let-7a: down-regulated -tissue_expression_down hsa-let-7a-3 "Lymphoma, Primary Effusion" 19252139 let-7a: down-regulated -tissue_expression_down hsa-let-7b Kaposi Sarcoma 19252139 let-7b: down-regulated -tissue_expression_down hsa-let-7b "Lymphoma, Primary Effusion" 19252139 let-7b: down-regulated -tissue_expression_down hsa-let-7c Kaposi Sarcoma 19252139 let-7c: down-regulated -tissue_expression_down hsa-let-7c "Lymphoma, Primary Effusion" 19252139 let-7c: down-regulated -tissue_expression_down hsa-let-7d Kaposi Sarcoma 19252139 let-7d: down-regulated -tissue_expression_down hsa-let-7d "Lymphoma, Primary Effusion" 19252139 let-7d: down-regulated -tissue_expression_down hsa-let-7e Kaposi Sarcoma 19252139 let-7e: down-regulated -tissue_expression_down hsa-let-7e "Lymphoma, Primary Effusion" 19252139 let-7e: down-regulated -tissue_expression_down hsa-let-7f-1 Kaposi Sarcoma 19252139 let-7f: down-regulated -tissue_expression_down hsa-let-7f-1 "Lymphoma, Primary Effusion" 19252139 let-7f: down-regulated -tissue_expression_down hsa-let-7f-2 Kaposi Sarcoma 19252139 let-7f: down-regulated -tissue_expression_down hsa-let-7f-2 "Lymphoma, Primary Effusion" 19252139 let-7f: down-regulated -tissue_expression_down hsa-let-7g Kaposi Sarcoma 19252139 let-7g: down-regulated -tissue_expression_down hsa-let-7g "Lymphoma, Primary Effusion" 19252139 let-7g: down-regulated -tissue_expression_down hsa-let-7i Kaposi Sarcoma 19252139 let-7i: down-regulated -tissue_expression_down hsa-let-7i "Lymphoma, Primary Effusion" 19252139 let-7i: down-regulated -tissue_expression_down hsa-mir-221 Kaposi Sarcoma 19252139 miR-221: down-regulated -tissue_expression_down hsa-mir-221 "Lymphoma, Primary Effusion" 19252139 miR-221: down-regulated -tissue_expression_down hsa-mir-222 Kaposi Sarcoma 19252139 miR-222: down-regulated -tissue_expression_down hsa-mir-222 "Lymphoma, Primary Effusion" 19252139 miR-222: down-regulated -tissue_expression_down hsa-mir-98 Kaposi Sarcoma 19252139 miR-98: down-regulated -tissue_expression_down hsa-mir-98 "Lymphoma, Primary Effusion" 19252139 miR-98: down-regulated -tissue_expression_down hsa-let-7g Endotoxemia 19284987 "Data analysis revealed that five miRNAs consistently responded to LPS-infusion, four of which were down-regulated (miR-146b, miR-150, miR-342, and let-7g) and one was up-regulated (miR-143). The miR-150 and mir-342 response was confirmed by real-time PCR." -tissue_expression_down hsa-mir-146b Endotoxemia 19284987 "Data analysis revealed that five miRNAs consistently responded to LPS-infusion, four of which were down-regulated (miR-146b, miR-150, miR-342, and let-7g) and one was up-regulated (miR-143). The miR-150 and mir-342 response was confirmed by real-time PCR." -tissue_expression_down hsa-mir-150 Endotoxemia 19284987 "Data analysis revealed that five miRNAs consistently responded to LPS-infusion, four of which were down-regulated (miR-146b, miR-150, miR-342, and let-7g) and one was up-regulated (miR-143). The miR-150 and mir-342 response was confirmed by real-time PCR." -tissue_expression_down hsa-mir-342 Endotoxemia 19284987 "Data analysis revealed that five miRNAs consistently responded to LPS-infusion, four of which were down-regulated (miR-146b, miR-150, miR-342, and let-7g) and one was up-regulated (miR-143). The miR-150 and mir-342 response was confirmed by real-time PCR." -tissue_expression_down hsa-mir-143 Colorectal Carcinoma 19287964 miR-143: down-regualted -tissue_expression_down hsa-mir-145 Colorectal Carcinoma 19287964 miR-145: down-regulated -tissue_expression_down hsa-mir-125b Breast Neoplasms 19290006 "Compared with normal breast samples, a panel of miRs was consistently dysregulated in breast cancer, including earlier-reported breast cancer-related miRs, such as upregulated miR-21, miR-155, miR-191, and miR-196a, and downregulated miR-125b and miR-221." -tissue_expression_down hsa-mir-221 Breast Neoplasms 19290006 "Compared with normal breast samples, a panel of miRs was consistently dysregulated in breast cancer, including earlier-reported breast cancer-related miRs, such as upregulated miR-21, miR-155, miR-191, and miR-196a, and downregulated miR-125b and miR-221." -tissue_expression_down hsa-mir-122a Primary Biliary Cirrhosis 19345069 A total of 35 independent miRNAs were found to be differentially expressed in PBC (p < 0.001).Quantitative PCR was employed to validate down-regulation of microRNA-122a (miR-122a) and miR-26a and the increased expression of miR-328 and miR-299-5p. -tissue_expression_down hsa-mir-26a Primary Biliary Cirrhosis 19345069 A total of 35 independent miRNAs were found to be differentially expressed in PBC (p < 0.001).Quantitative PCR was employed to validate down-regulation of microRNA-122a (miR-122a) and miR-26a and the increased expression of miR-328 and miR-299-5p. -tissue_expression_down hsa-mir-17 "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 19347736 miR-17-5p: down-regulated -tissue_expression_down hsa-mir-29a "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 19347736 miR-29: down-regulated -tissue_expression_down hsa-mir-29b-1 "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 19347736 miR-29: down-regulated -tissue_expression_down hsa-mir-29b-2 "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 19347736 miR-29: down-regulated -tissue_expression_down hsa-mir-29c "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 19347736 miR-29: down-regulated -tissue_expression_down hsa-mir-34a "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 19347736 miR-34a: down-regulated -tissue_expression_down hsa-let-7a-1 Salivary Gland Neoplasms 19347935 let-7a: down-regulated -tissue_expression_down hsa-let-7a-2 Salivary Gland Neoplasms 19347935 let-7a: down-regulated -tissue_expression_down hsa-let-7a-3 Salivary Gland Neoplasms 19347935 let-7a: down-regulated -tissue_expression_down hsa-mir-144 Salivary Gland Neoplasms 19347935 miR-144: down-regulated -tissue_expression_down hsa-mir-20b Salivary Gland Neoplasms 19347935 miR-20b: down-regulated -tissue_expression_down hsa-mir-375 Salivary Gland Neoplasms 19347935 miR-375: down-regulated -tissue_expression_down hsa-mir-106b "Carcinoma, Adrenocortical" 19351815 miR-106b: down-regulated -tissue_expression_down hsa-mir-139 "Carcinoma, Adrenocortical" 19351815 miR-139: down-regulated -tissue_expression_down hsa-mir-148a "Carcinoma, Adrenocortical" 19351815 miR-148a: down-regulated -tissue_expression_down hsa-mir-196a-1 "Carcinoma, Adrenocortical" 19351815 miR-196a: down-regulated -tissue_expression_down hsa-mir-196a-2 "Carcinoma, Adrenocortical" 19351815 miR-196a: down-regulated -tissue_expression_down hsa-mir-210 "Carcinoma, Adrenocortical" 19351815 miR-210: down-regulated -tissue_expression_down hsa-mir-301a "Carcinoma, Adrenocortical" 19351815 miR-301: down-regulated -tissue_expression_down hsa-mir-301b "Carcinoma, Adrenocortical" 19351815 miR-301: down-regulated -tissue_expression_down hsa-mir-376a-1 "Carcinoma, Adrenocortical" 19351815 miR-376: down-regulated -tissue_expression_down hsa-mir-376a-2 "Carcinoma, Adrenocortical" 19351815 miR-376: down-regulated -tissue_expression_down hsa-mir-376b "Carcinoma, Adrenocortical" 19351815 miR-376: down-regulated -tissue_expression_down hsa-mir-376c "Carcinoma, Adrenocortical" 19351815 miR-376: down-regulated -tissue_expression_down hsa-mir-424 "Carcinoma, Adrenocortical" 19351815 miR-424: down-regulated -tissue_expression_down hsa-mir-484 "Carcinoma, Adrenocortical" 19351815 miR-484: down-regulated -tissue_expression_down hsa-mir-491 "Carcinoma, Adrenocortical" 19351815 miR-491: down-regulated -tissue_expression_down hsa-mir-1-1 Hepatitis C Virus Infection 19360909 miR-1: down-regulated -tissue_expression_down hsa-mir-1-2 Hepatitis C Virus Infection 19360909 miR-1: down-regulated -tissue_expression_down hsa-mir-122 "Carcinoma, Hepatocellular" 19360909 miR-122: be decreased in HCC compared to non-tumoral tissue -tissue_expression_down hsa-mir-145 "Carcinoma, Hepatocellular" 19360909 miR-145: be decreased in HCC compared to non-tumoral tissue -tissue_expression_down hsa-mir-15a Liver Diseases [unspecific] 19360909 miR-15a: decreased -tissue_expression_down hsa-mir-196a-1 Hepatitis C Virus Infection 19360909 miR-196: down-regulated -tissue_expression_down hsa-mir-196a-2 Hepatitis C Virus Infection 19360909 miR-196: down-regulated -tissue_expression_down hsa-mir-196b Hepatitis C Virus Infection 19360909 miR-196: down-regulated -tissue_expression_down hsa-mir-198 "Carcinoma, Hepatocellular" 19360909 miR-198: up to five-fold down-regulated in hepatic tumors compared to normal liver parenchyma -tissue_expression_down hsa-mir-199a-1 "Carcinoma, Hepatocellular" 19360909 miR-199a: be decreased in HCC compared to non-tumoral tissue -tissue_expression_down hsa-mir-199a-2 "Carcinoma, Hepatocellular" 19360909 miR-199a: be decreased in HCC compared to non-tumoral tissue -tissue_expression_down hsa-mir-296 Hepatitis C Virus Infection 19360909 miR-296: down-regulated -tissue_expression_down hsa-mir-30a Hepatitis C Virus Infection 19360909 miR-30: down-regulated -tissue_expression_down hsa-mir-30b Hepatitis C Virus Infection 19360909 miR-30: down-regulated -tissue_expression_down hsa-mir-30c-1 Hepatitis C Virus Infection 19360909 miR-30: down-regulated -tissue_expression_down hsa-mir-30c-2 Hepatitis C Virus Infection 19360909 miR-30: down-regulated -tissue_expression_down hsa-mir-30d Hepatitis C Virus Infection 19360909 miR-30: down-regulated -tissue_expression_down hsa-mir-431 Hepatitis C Virus Infection 19360909 miR-431: down-regulated -tissue_expression_down hsa-mir-448 Hepatitis C Virus Infection 19360909 miR-448: down-regulated -tissue_expression_down hsa-mir-141 Gastric Neoplasms 19363643 miR-141: significantly down-regulated in gastric cancer -tissue_expression_down hsa-mir-125b Bladder Neoplasms 19378336 "We identified a subset of 7 miRNAs (miR-145, miR-30a-3p, miR-133a, miR-133b, miR-195, miR-125b and miR-199a*) that were significantly downregulated in BCs." -tissue_expression_down hsa-mir-133a Bladder Neoplasms 19378336 "We identified a subset of 7 miRNAs (miR-145, miR-30a-3p, miR-133a, miR-133b, miR-195, miR-125b and miR-199a*) that were significantly downregulated in BCs." -tissue_expression_down hsa-mir-133b Bladder Neoplasms 19378336 "We identified a subset of 7 miRNAs (miR-145, miR-30a-3p, miR-133a, miR-133b, miR-195, miR-125b and miR-199a*) that were significantly downregulated in BCs." -tissue_expression_down hsa-mir-145 Bladder Neoplasms 19378336 "We identified a subset of 7 miRNAs (miR-145, miR-30a-3p, miR-133a, miR-133b, miR-195, miR-125b and miR-199a*) that were significantly downregulated in BCs." -tissue_expression_down hsa-mir-195 Bladder Neoplasms 19378336 "We identified a subset of 7 miRNAs (miR-145, miR-30a-3p, miR-133a, miR-133b, miR-195, miR-125b and miR-199a*) that were significantly downregulated in BCs." -tissue_expression_down hsa-mir-199a Bladder Neoplasms 19378336 "We identified a subset of 7 miRNAs (miR-145, miR-30a-3p, miR-133a, miR-133b, miR-195, miR-125b and miR-199a*) that were significantly downregulated in BCs." -tissue_expression_down hsa-mir-30a Bladder Neoplasms 19378336 "We identified a subset of 7 miRNAs (miR-145, miR-30a-3p, miR-133a, miR-133b, miR-195, miR-125b and miR-199a*) that were significantly downregulated in BCs." -tissue_expression_down hsa-mir-1 Essential Thrombocythemia 19497108 Gene and microRNA analysis of neutrophils from patients with polycythemia vera and essential thrombocytosis: down-regulation of micro RNA-1 and -133a. -tissue_expression_down hsa-mir-133a Essential Thrombocythemia 19497108 Gene and microRNA analysis of neutrophils from patients with polycythemia vera and essential thrombocytosis: down-regulation of micro RNA-1 and -133a. -tissue_expression_down hsa-mir-141 Ovarian Neoplasms 19501389 "miR-200b-429 may be used as a prognostic marker for ovarian cancer outcome, and low-level expression of miR-200 miRNAs in this cluster predicts poor survival." -tissue_expression_down hsa-mir-200a Ovarian Neoplasms 19501389 "miR-200b-429 may be used as a prognostic marker for ovarian cancer outcome, and low-level expression of miR-200 miRNAs in this cluster predicts poor survival." -tissue_expression_down hsa-mir-200b Ovarian Neoplasms 19501389 "miR-200b-429 may be used as a prognostic marker for ovarian cancer outcome, and low-level expression of miR-200 miRNAs in this cluster predicts poor survival." -tissue_expression_down hsa-mir-200c Ovarian Neoplasms 19501389 "miR-200b-429 may be used as a prognostic marker for ovarian cancer outcome, and low-level expression of miR-200 miRNAs in this cluster predicts poor survival." -tissue_expression_down hsa-mir-429 Ovarian Neoplasms 19501389 "miR-200b-429 may be used as a prognostic marker for ovarian cancer outcome, and low-level expression of miR-200 miRNAs in this cluster predicts poor survival." -tissue_expression_down hsa-mir-433 Gastrointestinal Neoplasms 19531230 Down-regulated miR-9 and miR-433 in human gastric carcinoma. -tissue_expression_down hsa-mir-9 Gastrointestinal Neoplasms 19531230 Down-regulated miR-9 and miR-433 in human gastric carcinoma. -tissue_expression_down hsa-mir-214 Adrenal Cortex Neoplasms 19546168 significantly lower expressed -tissue_expression_down hsa-mir-183 Fatty Liver [unspecific] 19572984 down-regulated after Lieber-DeCarli ; -tissue_expression_down hsa-mir-122 Melanoma 19578755 down-regulated -tissue_expression_down hsa-mir-146b Melanoma 19578755 down-regulated -tissue_expression_down hsa-mir-155 Melanoma 19578755 down-regulated -tissue_expression_down hsa-mir-221 Prostate Neoplasms 19585579 miR-221:Expression of microRNA-221 is progressively reduced in aggressive prostate cancer and metastasis -tissue_expression_down hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 19591824 "The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma." -tissue_expression_down hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 19591824 "The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma." -tissue_expression_down hsa-mir-155 Lung Neoplasms 19597153 down-regulated miR -tissue_expression_down hsa-mir-17 Gastric Neoplasms 19598010 miR-17-92a cluster; expression lwere significantly lower than non-cancer tissue; may help to clarify the molecular mechanisms; may be a novel diagnostic biomarker -tissue_expression_down hsa-mir-18a Gastric Neoplasms 19598010 miR-17-92a cluster; expression lwere significantly lower than non-cancer tissue; may help to clarify the molecular mechanisms; may be a novel diagnostic biomarker -tissue_expression_down hsa-mir-19a Gastric Neoplasms 19598010 miR-17-92a cluster; expression lwere significantly lower than non-cancer tissue; may help to clarify the molecular mechanisms; may be a novel diagnostic biomarker -tissue_expression_down hsa-mir-142 Lung Neoplasms 19618089 "miR-34c, miR-145, or miR-142-5p expression markedly diminished proliferation of lung cancer cell lines, clinical implications discussed" -tissue_expression_down hsa-mir-145 Lung Neoplasms 19618089 "miR-34c, miR-145, or miR-142-5p expression markedly diminished proliferation of lung cancer cell lines, clinical implications discussed" -tissue_expression_down hsa-mir-18b Lung Neoplasms 19618089 "miR-34c, miR-145, or miR-142-5p expression markedly diminished proliferation of lung cancer cell lines, clinical implications discussed" -tissue_expression_down hsa-mir-133b Pancreatic Neoplasms 19654291 "downregulated, Up-regulation leads to the reversal of EMT" -tissue_expression_down hsa-mir-182 Breast Neoplasms 19665978 downregulated in human BCSCs -tissue_expression_down hsa-mir-183 Breast Neoplasms 19665978 downregulated in human BCSCs -tissue_expression_down hsa-mir-200a Breast Neoplasms 19665978 downregulated in human BCSCs -tissue_expression_down hsa-mir-429 Breast Neoplasms 19665978 downregulated in human BCSCs -tissue_expression_down hsa-mir-96 Breast Neoplasms 19665978 downregulated in human BCSCs -tissue_expression_down hsa-mir-143 Prostate Neoplasms 19671871 "Although miR-143 and miR-145 are highly expressed in normal tissues, they are significantly down-regulated in prostate cancer cells. " -tissue_expression_down hsa-mir-145 Prostate Neoplasms 19671871 "Although miR-143 and miR-145 are highly expressed in normal tissues, they are significantly down-regulated in prostate cancer cells. " -tissue_expression_down hsa-mir-145 Neoplasms [unspecific] 19676045 down-regulated -tissue_expression_down hsa-mir-149 Neoplasms [unspecific] 19676045 down-regulated -tissue_expression_down hsa-mir-182 Neoplasms [unspecific] 19676045 down-regulated -tissue_expression_down hsa-mir-184 Neoplasms [unspecific] 19676045 down-regulated -tissue_expression_down hsa-mir-205 Neoplasms [unspecific] 19676045 down-regulated -tissue_expression_down hsa-mir-221 Neoplasms [unspecific] 19676045 down-regulated -tissue_expression_down hsa-mir-222 Neoplasms [unspecific] 19676045 down-regulated -tissue_expression_down hsa-mir-31 Neoplasms [unspecific] 19676045 down-regulated -tissue_expression_down hsa-mir-499a Lymphoma 19690137 "deregulated, hypermutations" -tissue_expression_down hsa-mir-148a Hepatoblastoma 19701500 downregulated -tissue_expression_down hsa-mir-122 "Carcinoma, Hepatocellular" 19711427 down-regulation at early stage -tissue_expression_down hsa-mir-155 "Carcinoma, Hepatocellular" 19711427 "Real-time reverse transcription polymerase chain reaction (RT-PCR) analysis demonstrated up-regulation of oncogenic miR-155, miR-221/222, and miR-21 and down-regulation of the most abundant liver-specific miR-122 at early stages of hepatocarcinogenesis." -tissue_expression_down hsa-mir-21 "Carcinoma, Hepatocellular" 19711427 "Real-time reverse transcription polymerase chain reaction (RT-PCR) analysis demonstrated up-regulation of oncogenic miR-155, miR-221/222, and miR-21 and down-regulation of the most abundant liver-specific miR-122 at early stages of hepatocarcinogenesis." -tissue_expression_down hsa-mir-221 "Carcinoma, Hepatocellular" 19711427 "Real-time reverse transcription polymerase chain reaction (RT-PCR) analysis demonstrated up-regulation of oncogenic miR-155, miR-221/222, and miR-21 and down-regulation of the most abundant liver-specific miR-122 at early stages of hepatocarcinogenesis." -tissue_expression_down hsa-mir-222 "Carcinoma, Hepatocellular" 19711427 "Real-time reverse transcription polymerase chain reaction (RT-PCR) analysis demonstrated up-regulation of oncogenic miR-155, miR-221/222, and miR-21 and down-regulation of the most abundant liver-specific miR-122 at early stages of hepatocarcinogenesis." -tissue_expression_down hsa-mir-140 Osteoarthritis 19714579 down-regulated IL-1beta-induced ADAMTS5 -tissue_expression_down hsa-mir-16-1 Prostate Neoplasms 19738602 "microRNA (miR)-16, which is expressed at lower levels in prostate cancer cells, affects the proliferation of human prostate cancer cell lines both in vitro and in vivo" -tissue_expression_down hsa-mir-16-2 Prostate Neoplasms 19738602 "microRNA (miR)-16, which is expressed at lower levels in prostate cancer cells, affects the proliferation of human prostate cancer cell lines both in vitro and in vivo" -tissue_expression_down hsa-mir-1 Lung Neoplasms 19748927 "miR-21, mir-31, miR-130a, miR-146b and miR-377 were consistently upregulated, whereas miR-1 and miR-143 were downregulated in lung tumors relative to normal lungs." -tissue_expression_down hsa-mir-143 Lung Neoplasms 19748927 "miR-21, mir-31, miR-130a, miR-146b and miR-377 were consistently upregulated, whereas miR-1 and miR-143 were downregulated in lung tumors relative to normal lungs." -tissue_expression_down hsa-mir-203 Squamous Cell Carcinoma 19789312 "In adenocarcinoma patients, miR-21, miR-223, miR-192, and miR-194 expression was elevated, whereas miR-203 expression was reduced in cancerous compared with noncancerous tissue." -tissue_expression_down hsa-mir-34a Melanoma 19830692 "miR-34a:MiR-15b and miR-210 were significantly upregulated, miR-34a was significantly downregulated in melanomas" -tissue_expression_down hsa-mir-200b Adrenal Cortex Neoplasms 19849700 down-regulated -tissue_expression_down hsa-mir-203 Adrenal Cortex Neoplasms 19849700 down-regulated -tissue_expression_down hsa-mir-218 Gastrointestinal Neoplasms 19890957 "miR-218 expression was reduced significantly in gastric cancer tissues, in H. pylori-infected gastric mucosa, and in H. pylori-infected AGS cells." -tissue_expression_down hsa-mir-10b "Adenocarcinoma, Endometrial" 19891660 down-regulated -tissue_expression_down hsa-mir-152 "Adenocarcinoma, Endometrial" 19891660 down-regulated -tissue_expression_down hsa-mir-145 Bladder Neoplasms 19915607 Our data indicate that reduction in miR-145 expression may provide bladder cancer cells with a selective advantage by inhibition of cell death otherwise triggered in malignant cells. -tissue_expression_down hsa-mir-128-1 Glioblastoma 19941032 "miR-128:Micro-RNA-128 (miRNA-128) down-regulation in glioblastoma targets ARP5 (ANGPTL6), Bmi-1 and E2F-3a, key regulators of brain cell proliferation" -tissue_expression_down hsa-mir-128-2 Glioblastoma 19941032 "miR-128:Micro-RNA-128 (miRNA-128) down-regulation in glioblastoma targets ARP5 (ANGPTL6), Bmi-1 and E2F-3a, key regulators of brain cell proliferation" -tissue_expression_down hsa-mir-133b Breast Neoplasms 19946373 downregulated -tissue_expression_down hsa-mir-133b Colon Neoplasms 19946373 downregulated -tissue_expression_down hsa-mir-133b Liver Neoplasms 19946373 downregulated -tissue_expression_down hsa-mir-133b Lung Neoplasms 19946373 downregulated -tissue_expression_down hsa-mir-133b Lymphoma 19946373 downregulated -tissue_expression_down hsa-mir-133b Ovarian Neoplasms 19946373 downregulated -tissue_expression_down hsa-mir-133b Prostate Neoplasms 19946373 downregulated -tissue_expression_down hsa-mir-133b Testicular Neoplasms 19946373 downregulated -tissue_expression_down hsa-mir-486 Breast Neoplasms 19946373 miR-486-5p: downregulated -tissue_expression_down hsa-mir-486 Colon Neoplasms 19946373 miR-486-5p: downregulated -tissue_expression_down hsa-mir-486 Liver Neoplasms 19946373 miR-486-5p: downregulated -tissue_expression_down hsa-mir-486 Lung Neoplasms 19946373 miR-486-5p: downregulated -tissue_expression_down hsa-mir-486 Lymphoma 19946373 miR-486-5p: downregulated -tissue_expression_down hsa-mir-486 Ovarian Neoplasms 19946373 miR-486-5p: downregulated -tissue_expression_down hsa-mir-486 Prostate Neoplasms 19946373 miR-486-5p: downregulated -tissue_expression_down hsa-mir-486 Testicular Neoplasms 19946373 miR-486-5p: downregulated -tissue_expression_down hsa-mir-130a Gastric Neoplasms 19948396 "different miRNAs have been found to predict sensitivity to anticancer treatment: miR-30c, miR-130a and miR-335 are downregulated in various chemoresistant cell lines, hsa-Let-7g and hsa-miR-181b are strongly associated with response to 5-fluorouracil-based antimetabolite S-1" -tissue_expression_down hsa-mir-30c Gastric Neoplasms 19948396 "different miRNAs have been found to predict sensitivity to anticancer treatment: miR-30c, miR-130a and miR-335 are downregulated in various chemoresistant cell lines, hsa-Let-7g and hsa-miR-181b are strongly associated with response to 5-fluorouracil-based antimetabolite S-1" -tissue_expression_down hsa-mir-335 Gastric Neoplasms 19948396 "different miRNAs have been found to predict sensitivity to anticancer treatment: miR-30c, miR-130a and miR-335 are downregulated in various chemoresistant cell lines, hsa-Let-7g and hsa-miR-181b are strongly associated with response to 5-fluorouracil-based antimetabolite S-1" -tissue_expression_down hsa-mir-1826 Colon Neoplasms 19956872 "The down-regulations of miR-197, miR-191, miR-92a, miR-93, miR-222 and miR-1826, whose expression was significantly down-regulated in both cell lines after the treatment of one drug or in one cell line following exposure to either drug, were further validated." -tissue_expression_down hsa-mir-191 Colon Neoplasms 19956872 "The down-regulations of miR-197, miR-191, miR-92a, miR-93, miR-222 and miR-1826, whose expression was significantly down-regulated in both cell lines after the treatment of one drug or in one cell line following exposure to either drug, were further validated." -tissue_expression_down hsa-mir-197 Colon Neoplasms 19956872 "The down-regulations of miR-197, miR-191, miR-92a, miR-93, miR-222 and miR-1826, whose expression was significantly down-regulated in both cell lines after the treatment of one drug or in one cell line following exposure to either drug, were further validated." -tissue_expression_down hsa-mir-222 Colon Neoplasms 19956872 "The down-regulations of miR-197, miR-191, miR-92a, miR-93, miR-222 and miR-1826, whose expression was significantly down-regulated in both cell lines after the treatment of one drug or in one cell line following exposure to either drug, were further validated." -tissue_expression_down hsa-mir-92a Colon Neoplasms 19956872 "The down-regulations of miR-197, miR-191, miR-92a, miR-93, miR-222 and miR-1826, whose expression was significantly down-regulated in both cell lines after the treatment of one drug or in one cell line following exposure to either drug, were further validated." -tissue_expression_down hsa-mir-93 Colon Neoplasms 19956872 "The down-regulations of miR-197, miR-191, miR-92a, miR-93, miR-222 and miR-1826, whose expression was significantly down-regulated in both cell lines after the treatment of one drug or in one cell line following exposure to either drug, were further validated." -tissue_expression_down hsa-mir-195 Adrenal Cortex Neoplasms 19996210 miR-335 and miR-195 were significantly downregulated in adrenocortical carcinomas -tissue_expression_down hsa-mir-483 Adrenal Cortex Neoplasms 19996210 miR-335 and miR-195 were significantly downregulated in adrenocortical carcinomas -tissue_expression_down hsa-mir-320a Interstitial Cystitis 20008142 "demonstrate a direct correlation between miR-449b, miR-500, miR-328, and miR-320 and a down-regulation of NK1R mRNA and/or protein levels" -tissue_expression_down hsa-mir-320b-1 Interstitial Cystitis 20008142 "demonstrate a direct correlation between miR-449b, miR-500, miR-328, and miR-320 and a down-regulation of NK1R mRNA and/or protein levels" -tissue_expression_down hsa-mir-320b-2 Interstitial Cystitis 20008142 "demonstrate a direct correlation between miR-449b, miR-500, miR-328, and miR-320 and a down-regulation of NK1R mRNA and/or protein levels" -tissue_expression_down hsa-mir-320c-1 Interstitial Cystitis 20008142 "demonstrate a direct correlation between miR-449b, miR-500, miR-328, and miR-320 and a down-regulation of NK1R mRNA and/or protein levels" -tissue_expression_down hsa-mir-320c-2 Interstitial Cystitis 20008142 "demonstrate a direct correlation between miR-449b, miR-500, miR-328, and miR-320 and a down-regulation of NK1R mRNA and/or protein levels" -tissue_expression_down hsa-mir-320d-1 Interstitial Cystitis 20008142 "demonstrate a direct correlation between miR-449b, miR-500, miR-328, and miR-320 and a down-regulation of NK1R mRNA and/or protein levels" -tissue_expression_down hsa-mir-320d-2 Interstitial Cystitis 20008142 "demonstrate a direct correlation between miR-449b, miR-500, miR-328, and miR-320 and a down-regulation of NK1R mRNA and/or protein levels" -tissue_expression_down hsa-mir-328 Interstitial Cystitis 20008142 "demonstrate a direct correlation between miR-449b, miR-500, miR-328, and miR-320 and a down-regulation of NK1R mRNA and/or protein levels" -tissue_expression_down hsa-mir-449b Interstitial Cystitis 20008142 "demonstrate a direct correlation between miR-449b, miR-500, miR-328, and miR-320 and a down-regulation of NK1R mRNA and/or protein levels" -tissue_expression_down hsa-mir-500a Interstitial Cystitis 20008142 "demonstrate a direct correlation between miR-449b, miR-500, miR-328, and miR-320 and a down-regulation of NK1R mRNA and/or protein levels" -tissue_expression_down hsa-let-7g Gastric Neoplasms 20022810 low expression -tissue_expression_down hsa-mir-433 Gastric Neoplasms 20022810 Low expression -tissue_expression_down hsa-mir-153-1 Endometrial Neoplasms 20028871 "Expression of miR-9, miR-27, miR-96, miR-153, miR-182, miR-183, or miR-186, but not miR-29a, miR-128, miR-152, or miR-486 mimetics in HEC-1B cells was sufficient to significantly reduce the abundance of FOXO1" -tissue_expression_down hsa-mir-153-2 Endometrial Neoplasms 20028871 "Expression of miR-9, miR-27, miR-96, miR-153, miR-182, miR-183, or miR-186, but not miR-29a, miR-128, miR-152, or miR-486 mimetics in HEC-1B cells was sufficient to significantly reduce the abundance of FOXO1" -tissue_expression_down hsa-mir-182 Endometrial Neoplasms 20028871 "Expression of miR-9, miR-27, miR-96, miR-153, miR-182, miR-183, or miR-186, but not miR-29a, miR-128, miR-152, or miR-486 mimetics in HEC-1B cells was sufficient to significantly reduce the abundance of FOXO1" -tissue_expression_down hsa-mir-183 Endometrial Neoplasms 20028871 "Expression of miR-9, miR-27, miR-96, miR-153, miR-182, miR-183, or miR-186, but not miR-29a, miR-128, miR-152, or miR-486 mimetics in HEC-1B cells was sufficient to significantly reduce the abundance of FOXO1" -tissue_expression_down hsa-mir-186 Endometrial Neoplasms 20028871 "Expression of miR-9, miR-27, miR-96, miR-153, miR-182, miR-183, or miR-186, but not miR-29a, miR-128, miR-152, or miR-486 mimetics in HEC-1B cells was sufficient to significantly reduce the abundance of FOXO1" -tissue_expression_down hsa-mir-27a Endometrial Neoplasms 20028871 "Expression of miR-9, miR-27, miR-96, miR-153, miR-182, miR-183, or miR-186, but not miR-29a, miR-128, miR-152, or miR-486 mimetics in HEC-1B cells was sufficient to significantly reduce the abundance of FOXO1" -tissue_expression_down hsa-mir-27b Endometrial Neoplasms 20028871 "Expression of miR-9, miR-27, miR-96, miR-153, miR-182, miR-183, or miR-186, but not miR-29a, miR-128, miR-152, or miR-486 mimetics in HEC-1B cells was sufficient to significantly reduce the abundance of FOXO1" -tissue_expression_down hsa-mir-9-1 Endometrial Neoplasms 20028871 "Expression of miR-9, miR-27, miR-96, miR-153, miR-182, miR-183, or miR-186, but not miR-29a, miR-128, miR-152, or miR-486 mimetics in HEC-1B cells was sufficient to significantly reduce the abundance of FOXO1" -tissue_expression_down hsa-mir-9-2 Endometrial Neoplasms 20028871 "Expression of miR-9, miR-27, miR-96, miR-153, miR-182, miR-183, or miR-186, but not miR-29a, miR-128, miR-152, or miR-486 mimetics in HEC-1B cells was sufficient to significantly reduce the abundance of FOXO1" -tissue_expression_down hsa-mir-9-3 Endometrial Neoplasms 20028871 "Expression of miR-9, miR-27, miR-96, miR-153, miR-182, miR-183, or miR-186, but not miR-29a, miR-128, miR-152, or miR-486 mimetics in HEC-1B cells was sufficient to significantly reduce the abundance of FOXO1" -tissue_expression_down hsa-mir-96 Endometrial Neoplasms 20028871 "Expression of miR-9, miR-27, miR-96, miR-153, miR-182, miR-183, or miR-186, but not miR-29a, miR-128, miR-152, or miR-486 mimetics in HEC-1B cells was sufficient to significantly reduce the abundance of FOXO1" -tissue_expression_down hsa-mir-133b Myocardial Infarction 20029200 downregulated -tissue_expression_down hsa-let-7a-1 Ovarian Neoplasms 20035894 hsa-let-7a:The most frequently deregulated miRNAs are members of the let-7 and miR-200 families -tissue_expression_down hsa-let-7a-2 Ovarian Neoplasms 20035894 hsa-let-7a:The most frequently deregulated miRNAs are members of the let-7 and miR-200 families -tissue_expression_down hsa-let-7a-3 Ovarian Neoplasms 20035894 hsa-let-7a:The most frequently deregulated miRNAs are members of the let-7 and miR-200 families -tissue_expression_down hsa-let-7b Ovarian Neoplasms 20035894 hsa-let-7b:The most frequently deregulated miRNAs are members of the let-7 and miR-200 families -tissue_expression_down hsa-let-7c Ovarian Neoplasms 20035894 hsa-let-7c:The most frequently deregulated miRNAs are members of the let-7 and miR-200 families -tissue_expression_down hsa-let-7d Ovarian Neoplasms 20035894 hsa-let-7d:The most frequently deregulated miRNAs are members of the let-7 and miR-200 families -tissue_expression_down hsa-let-7e Ovarian Neoplasms 20035894 hsa-let-7e:The most frequently deregulated miRNAs are members of the let-7 and miR-200 families -tissue_expression_down hsa-let-7f-1 Ovarian Neoplasms 20035894 hsa-let-7f:The most frequently deregulated miRNAs are members of the let-7 and miR-200 families -tissue_expression_down hsa-let-7f-2 Ovarian Neoplasms 20035894 hsa-let-7f:The most frequently deregulated miRNAs are members of the let-7 and miR-200 families -tissue_expression_down hsa-let-7g Ovarian Neoplasms 20035894 hsa-let-7g:The most frequently deregulated miRNAs are members of the let-7 and miR-200 families -tissue_expression_down hsa-let-7i Ovarian Neoplasms 20035894 hsa-let-7i:The most frequently deregulated miRNAs are members of the let-7 and miR-200 families -tissue_expression_down hsa-mir-34a Pancreatic Neoplasms 20037478 "Finally,restituted expression of miR-34a, a miRNA whose expression is frequently lost in PDAC cell lines, abrogates growth, demonstrating that the anti-proliferative activity of this miRNA is operative in PDAC." -tissue_expression_down hsa-mir-378 Colon Neoplasms 20132431 "A total of 14 miRNAs were found to be associated with colonic cancer, in which the expression of miR-106b, miR-135b, miR-18a, miR-18b, miR-196b, miR-19a, miR-224, miR-335, miR-424, miR-20a*, miR-301b and miR-374a were up-regulated and the expression of miR-378 and miR-378* were downregulated in colonic cancer tissues, compared with the para-cancerous control." -tissue_expression_down hsa-mir-34b Ovarian Neoplasms 20145172 reduced expression of miR-34b*/c may be particularly important for progression to the most advanced stages -tissue_expression_down hsa-mir-34c Ovarian Neoplasms 20145172 reduced expression of miR-34b*/c may be particularly important for progression to the most advanced stages -tissue_expression_down hsa-mir-10a Neoplasms [unspecific] 20145181 downregulation -tissue_expression_down hsa-mir-10a "Squamous Cell Carcinoma, Head and Neck" 20145181 downregulation -tissue_expression_down hsa-mir-10b Neoplasms [unspecific] 20145181 downregulation -tissue_expression_down hsa-mir-125b-1 Neoplasms [unspecific] 20145181 underexpression -tissue_expression_down hsa-mir-125b-2 Neoplasms [unspecific] 20145181 underexpression -tissue_expression_down hsa-mir-375 Neoplasms [unspecific] 20145181 underexpression -tissue_expression_down hsa-mir-375 "Squamous Cell Carcinoma, Head and Neck" 20145181 underexpression -tissue_expression_down hsa-mir-34c Prostate Neoplasms 20162671 miR-34c is down regulated in prostate cancer and exerts tumor suppressive functions -tissue_expression_down hsa-mir-133a-1 Cardiovascular Diseases [unspecific] 20173049 miR-133a:NFATc4 is negatively regulated in miR-133a-mediated cardiomyocyte hypertrophic repression -tissue_expression_down hsa-mir-126 Myocardial Infarction 20187981 we found that AMI is associated with altered miRNA expression level and the differentially expressed miRNAs may be novel biomarkers of AMI -tissue_expression_down hsa-mir-31 Myocardial Infarction 20187981 we found that AMI is associated with altered miRNA expression level and the differentially expressed miRNAs may be novel biomarkers of AMI -tissue_expression_down hsa-mir-499a Myocardial Infarction 20187981 miR-499-5p; we found that AMI is associated with altered miRNA expression level and the differentially expressed miRNAs may be novel biomarkers of AMI -tissue_expression_down hsa-mir-375 Neoplasms [unspecific] 20215506 MicroRNA-375 is downregulated in gastric carcinomas -tissue_expression_down hsa-mir-150 Polycythemia Vera 20218812 We observed that miR-451 up-regulation and miR-150 down-regulation are associated with progression of erythroid maturation in K562 cells. -tissue_expression_down hsa-mir-106a Astrocytoma 20219352 "miR-106a:hsa-miR-21, hsa-miR-181b and hsa-miR-106a as prognostic indicators of astrocytoma" -tissue_expression_down hsa-mir-137 Astrocytoma 20219352 miR-137:The down-regulation of hsa-miR-137 in astrocytomas was shown to be associated with advanced clinical stages of this disease -tissue_expression_down hsa-mir-181b-1 Astrocytoma 20219352 "miR-181b:hsa-miR-21, hsa-miR-181b and hsa-miR-106a as prognostic indicators of astrocytoma" -tissue_expression_down hsa-mir-181b-2 Astrocytoma 20219352 "miR-181b:hsa-miR-21, hsa-miR-181b and hsa-miR-106a as prognostic indicators of astrocytoma" -tissue_expression_down hsa-let-7b "Carcinoma, Oral" 20232482 "Together, these data demonstrate that elevated expression levels of Dicer in oral cancer cells correlate with downregulation of let-7b and increased cell proliferation." -tissue_expression_down hsa-mir-145 Breast Neoplasms 20331864 down-regulated in male breast cancer -tissue_expression_down hsa-mir-497 Breast Neoplasms 20331864 down-regulated in male breast cancer -tissue_expression_down hsa-mir-34a Choriocarcinoma 20351093 MicroRNA-34a suppresses invasion through down-regulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells -tissue_expression_down hsa-mir-191 Melanoma 20357817 "Furthermore, low expression of miR-191 and high expression of miR-193b were associated with poor melanoma-specific survive" -tissue_expression_down hsa-mir-193a Melanoma 20357817 "In melanomas, miR-193a, miR-338, and miR-565 were underexpressed in cases with a BRAF mutation." -tissue_expression_down hsa-mir-338 Melanoma 20357817 "In melanomas, miR-193a, miR-338, and miR-565 were underexpressed in cases with a BRAF mutation." -tissue_expression_down hsa-mir-143 "Carcinoma, Lung, Non-Small-Cell" 20363096 "miR-143:Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis" -tissue_expression_down hsa-mir-143 Lung Neoplasms 20363096 "downregulated; Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis" -tissue_expression_down hsa-mir-181a-2 "Carcinoma, Lung, Non-Small-Cell" 20363096 "miR-181a:Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis" -tissue_expression_down hsa-mir-181a-2 Lung Neoplasms 20363096 "downregulated; Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis" -tissue_expression_down hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 20363096 "miR-21:Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis" -tissue_expression_down hsa-mir-145 Neoplasms [unspecific] 20370992 under-expressed -tissue_expression_down hsa-mir-155 Neoplasms [unspecific] 20370992 under-expressed -tissue_expression_down hsa-let-7a-1 Colorectal Adenocarcinoma 20413677 "let-7a:nine(miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC" -tissue_expression_down hsa-let-7a-2 Colorectal Adenocarcinoma 20413677 "let-7a:nine(miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC" -tissue_expression_down hsa-let-7a-3 Colorectal Adenocarcinoma 20413677 "let-7a:nine(miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC" -tissue_expression_down hsa-mir-143 Colorectal Adenocarcinoma 20413677 "miR-143:nine(miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC" -tissue_expression_down hsa-mir-145 Colorectal Adenocarcinoma 20413677 "miR-145:nine(miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC" -tissue_expression_down hsa-mir-16-1 Colorectal Adenocarcinoma 20413677 "miR-16:nine(miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC" -tissue_expression_down hsa-mir-16-2 Colorectal Adenocarcinoma 20413677 "miR-16:nine(miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC" -tissue_expression_down hsa-mir-191 Colorectal Adenocarcinoma 20413677 "miR-191:nine(miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC" -tissue_expression_down hsa-mir-192 Colorectal Adenocarcinoma 20413677 "miR-192:nine(miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC" -tissue_expression_down hsa-mir-196a-1 Colorectal Adenocarcinoma 20413677 "miR-196a:nine(miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC" -tissue_expression_down hsa-mir-196a-2 Colorectal Adenocarcinoma 20413677 "miR-196a:nine(miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC" -tissue_expression_down hsa-mir-215 Colorectal Adenocarcinoma 20413677 "miR-215:nine(miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC" -tissue_expression_down hsa-mir-26b Colorectal Adenocarcinoma 20413677 "miR-26b:nine(miR-192, -215, -26b, -143, -145, -191, -196a, -16, and let-7a) were under-expressed in CRC" -tissue_expression_down hsa-mir-148a Gastrointestinal Neoplasms 20422307 MiR-148a:MiR-148a and miR-152 may be involved in the carcinogenesis of gastrointestinal cancers and might be potential biomarkers -tissue_expression_down hsa-mir-152 Gastrointestinal Neoplasms 20422307 MiR-152:MiR-148a and miR-152 may be involved in the carcinogenesis of gastrointestinal cancers and might be potential biomarkers -tissue_expression_down hsa-mir-103a-1 Neoplasms [unspecific] 20439436 "miR-103:hsa-miR-103/106 were downgraded in cancer, whereas hsa-miR-30 became most prominent" -tissue_expression_down hsa-mir-103a-2 Neoplasms [unspecific] 20439436 "miR-103:hsa-miR-103/106 were downgraded in cancer, whereas hsa-miR-30 became most prominent" -tissue_expression_down hsa-mir-106a Neoplasms [unspecific] 20439436 "miR-106:hsa-miR-103/106 were downgraded in cancer, whereas hsa-miR-30 became most prominent" -tissue_expression_down hsa-mir-200c Melanoma 20442294 "miRNA-200c:miRNA-200c to be consistently downregulated in melanocytes, melanoma cell lines, and patient samples, whereas miRNA-205 and miRNA-23b were markedly reduced only in patient samples" -tissue_expression_down hsa-mir-205 Melanoma 20442294 "miRNA-205:miRNA-200c to be consistently downregulated in melanocytes, melanoma cell lines, and patient samples, whereas miRNA-205 and miRNA-23b were markedly reduced only in patient samples" -tissue_expression_down hsa-mir-23b Melanoma 20442294 "miRNA-23b:miRNA-200c to be consistently downregulated in melanocytes, melanoma cell lines, and patient samples, whereas miRNA-205 and miRNA-23b were markedly reduced only in patient samples" -tissue_expression_down hsa-mir-34a Cervical Neoplasms 20442590 Reduced miR-34a expression in normal cervical tissues and cervical lesions with high-risk human papillomavirus infection. -tissue_expression_down hsa-mir-17 "Lymphoma, T-Cell" 20448109 mir-17:down-regulation of the miR-17-92 cluster in malignancy -tissue_expression_down hsa-mir-18a "Lymphoma, T-Cell" 20448109 mir-18a:down-regulation of the miR-17-92 cluster in malignancy -tissue_expression_down hsa-mir-19a "Lymphoma, T-Cell" 20448109 mir-19a:down-regulation of the miR-17-92 cluster in malignancy -tissue_expression_down hsa-mir-19b-1 "Lymphoma, T-Cell" 20448109 mir-19b:down-regulation of the miR-17-92 cluster in malignancy -tissue_expression_down hsa-mir-19b-2 "Lymphoma, T-Cell" 20448109 mir-19b:down-regulation of the miR-17-92 cluster in malignancy -tissue_expression_down hsa-mir-20a "Lymphoma, T-Cell" 20448109 mir-20a:down-regulation of the miR-17-92 cluster in malignancy -tissue_expression_down hsa-mir-92a-1 "Lymphoma, T-Cell" 20448109 mir-92a:down-regulation of the miR-17-92 cluster in malignancy -tissue_expression_down hsa-mir-92a-2 "Lymphoma, T-Cell" 20448109 mir-92a:down-regulation of the miR-17-92 cluster in malignancy -tissue_expression_down hsa-mir-132 Osteoarthritis 20470394 "In RA and OA, synovial fluid concentrations of miR-16, miR-132, miR-146a, and miR-223 were significantly lower than their plasma concentrations, and there were no correlation between plasma and synovial fluid miRNAs." -tissue_expression_down hsa-mir-146a Osteoarthritis 20470394 "In RA and OA, synovial fluid concentrations of miR-16, miR-132, miR-146a, and miR-223 were significantly lower than their plasma concentrations, and there were no correlation between plasma and synovial fluid miRNAs." -tissue_expression_down hsa-mir-16 Osteoarthritis 20470394 "In RA and OA, synovial fluid concentrations of miR-16, miR-132, miR-146a, and miR-223 were significantly lower than their plasma concentrations, and there were no correlation between plasma and synovial fluid miRNAs." -tissue_expression_down hsa-mir-223 Osteoarthritis 20470394 "In RA and OA, synovial fluid concentrations of miR-16, miR-132, miR-146a, and miR-223 were significantly lower than their plasma concentrations, and there were no correlation between plasma and synovial fluid miRNAs." -tissue_expression_down hsa-mir-200a Neoplasms [unspecific] 20484038 miR-200a:Downregulation of microRNA-200 in EBV-associated gastric carcinoma -tissue_expression_down hsa-mir-200b Neoplasms [unspecific] 20484038 miR-200b:Downregulation of microRNA-200 in EBV-associated gastric carcinoma -tissue_expression_down hsa-mir-200c Neoplasms [unspecific] 20484038 miR-200c:Downregulation of microRNA-200 in EBV-associated gastric carcinoma -tissue_expression_down hsa-mir-107 Heart Failure 20484156 miR-107: downregulated -tissue_expression_down hsa-mir-139 Heart Failure 20484156 miR-139: downregulated -tissue_expression_down hsa-mir-142 Heart Failure 20484156 miR-142-5p: downregulated -tissue_expression_down hsa-mir-100 Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_down hsa-mir-101 Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_down hsa-mir-125b Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_down hsa-mir-126 Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_down hsa-mir-130a Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_down hsa-mir-143 Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_down hsa-mir-145 Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_down hsa-mir-181a Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_down hsa-mir-26a Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_down hsa-mir-26b Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_down hsa-mir-29a Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_down hsa-mir-29c Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_down hsa-mir-30a Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_down hsa-mir-30b Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_down hsa-mir-30d Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_down hsa-mir-30e Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_down hsa-mir-320 Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_down hsa-mir-451 Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_down hsa-mir-652 Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_down hsa-mir-886 Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_down hsa-mir-99a Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_down hsa-mir-218 Gastrointestinal Neoplasms 20510072 miR-218 expression is reduced in gastric cancer. miR-218 may function as a tumor suppressor in gastric carcinoma. -tissue_expression_down hsa-mir-125a "Carcinoma, Lung, Non-Small-Cell" 20569443 miR-125a-3p:Hsa-miR-125a-3p and hsa-miR-125a-5p are downregulated in non-small cell lung cancer -tissue_expression_down hsa-mir-34a Melanoma 20606648 miR-34a delivered by the GC4-targeted nanoparticles significantly downregulated the survivin expression in the metastatic tumor and reduced tumor load in the lung. -tissue_expression_down hsa-mir-106b "Carcinoma, Renal Cell" 20609231 miRNA-106b:Expression of miRNA-106b in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy -tissue_expression_down hsa-mir-101-1 "Squamous Cell Carcinoma, Lung" 20620595 "miR-101:Seven human miRNAs (miR-126, miR-193a-3p, miR-30d, miR-30a, miR-101, let-7i, and miR-15a) were found to be significantly downregulated in lung SCC" -tissue_expression_down hsa-mir-101-2 "Squamous Cell Carcinoma, Lung" 20620595 "miR-101:Seven human miRNAs (miR-126, miR-193a-3p, miR-30d, miR-30a, miR-101, let-7i, and miR-15a) were found to be significantly downregulated in lung SCC" -tissue_expression_down hsa-mir-126 "Squamous Cell Carcinoma, Lung" 20620595 "miR-126:Seven human miRNAs (miR-126, miR-193a-3p, miR-30d, miR-30a, miR-101, let-7i, and miR-15a) were found to be significantly downregulated in lung SCC" -tissue_expression_down hsa-mir-15a "Squamous Cell Carcinoma, Lung" 20620595 "miR-15a:Seven human miRNAs (miR-126, miR-193a-3p, miR-30d, miR-30a, miR-101, let-7i, and miR-15a) were found to be significantly downregulated in lung SCC" -tissue_expression_down hsa-mir-193a "Squamous Cell Carcinoma, Lung" 20620595 "miR-193a-3p:Seven human miRNAs (miR-126, miR-193a-3p, miR-30d, miR-30a, miR-101, let-7i, and miR-15a) were found to be significantly downregulated in lung SCC" -tissue_expression_down hsa-mir-30a "Squamous Cell Carcinoma, Lung" 20620595 "miR-30a:Seven human miRNAs (miR-126, miR-193a-3p, miR-30d, miR-30a, miR-101, let-7i, and miR-15a) were found to be significantly downregulated in lung SCC" -tissue_expression_down hsa-mir-30d "Squamous Cell Carcinoma, Lung" 20620595 "miR-30d:Seven human miRNAs (miR-126, miR-193a-3p, miR-30d, miR-30a, miR-101, let-7i, and miR-15a) were found to be significantly downregulated in lung SCC" -tissue_expression_down hsa-mir-520h Pancreatic Neoplasms 20628378 "miR-520h:miR-520h downregulates ABCG2 in pancreatic cancer cells to inhibit migration, invasion, and side populations" -tissue_expression_down hsa-let-7e Adenovirus Infection 20634878 let-7e:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-101-1 Adenovirus Infection 20634878 miR-101-1:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-101-2 Adenovirus Infection 20634878 miR-101-2:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-1180 Adenovirus Infection 20634878 hsa-mir-1180:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-1184-1 Adenovirus Infection 20634878 miR-1184:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-125b-1 Adenovirus Infection 20634878 miR-125b-1:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-125b-2 Adenovirus Infection 20634878 miR-125b-2:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-148a Adenovirus Infection 20634878 miR-148a:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-148b Adenovirus Infection 20634878 miR-148b:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-181b-1 Adenovirus Infection 20634878 miR-181b-1:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-181b-2 Adenovirus Infection 20634878 miR-181b-2:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-18b Adenovirus Infection 20634878 miR-18b:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-196b Adenovirus Infection 20634878 miR-196b:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-19b-1 Adenovirus Infection 20634878 miR-19b-1:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-19b-2 Adenovirus Infection 20634878 miR-19b-2:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-210 Adenovirus Infection 20634878 miR-210:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-219-1 Adenovirus Infection 20634878 miR-219-1:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-25 Adenovirus Infection 20634878 miR-25:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-26b Adenovirus Infection 20634878 miR-26b:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-27a Adenovirus Infection 20634878 miR-27a:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-27b Adenovirus Infection 20634878 miR-27b:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-30a Adenovirus Infection 20634878 miR-30a:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-30b Adenovirus Infection 20634878 miR-30b:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-30c-1 Adenovirus Infection 20634878 miR-30c-1:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-30c-2 Adenovirus Infection 20634878 miR-30c-2:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-338 Adenovirus Infection 20634878 miR-338:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-33a Adenovirus Infection 20634878 miR-33a:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-34a Adenovirus Infection 20634878 miR-34a:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-362 Adenovirus Infection 20634878 miR-362:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-374b Adenovirus Infection 20634878 miR-374b:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-421 Adenovirus Infection 20634878 miR-421:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-433 Adenovirus Infection 20634878 miR-433:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-452 Adenovirus Infection 20634878 miR-452:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-519a-1 Adenovirus Infection 20634878 miR-519a-1:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-582 Adenovirus Infection 20634878 miR-582:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-619 Adenovirus Infection 20634878 miR-619:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-650 Adenovirus Infection 20634878 miR-650:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-655 Adenovirus Infection 20634878 miR-655:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-92a-2 Adenovirus Infection 20634878 miR-92a-2:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_down hsa-mir-451 Glioblastoma 20647762 We initially identified miR-451 due to its downregulation in a glioma cell migration assay. -tissue_expression_down hsa-mir-142 Squamous Cell Carcinoma 20652977 "The miRNAs miR-363, miR-33, and miR-497 were upregulated, whereas miR-155, miR-181a, miR-181b, miR-29a, miR-218, miR-222, miR-221, and miR-142-5p were downregulated in HPV-positive cells compared to both HPV-negative SCCHN and normal oral keratinocytes." -tissue_expression_down hsa-mir-155 Squamous Cell Carcinoma 20652977 "The miRNAs miR-363, miR-33, and miR-497 were upregulated, whereas miR-155, miR-181a, miR-181b, miR-29a, miR-218, miR-222, miR-221, and miR-142-5p were downregulated in HPV-positive cells compared to both HPV-negative SCCHN and normal oral keratinocytes." -tissue_expression_down hsa-mir-181a Squamous Cell Carcinoma 20652977 "The miRNAs miR-363, miR-33, and miR-497 were upregulated, whereas miR-155, miR-181a, miR-181b, miR-29a, miR-218, miR-222, miR-221, and miR-142-5p were downregulated in HPV-positive cells compared to both HPV-negative SCCHN and normal oral keratinocytes." -tissue_expression_down hsa-mir-181b Squamous Cell Carcinoma 20652977 "The miRNAs miR-363, miR-33, and miR-497 were upregulated, whereas miR-155, miR-181a, miR-181b, miR-29a, miR-218, miR-222, miR-221, and miR-142-5p were downregulated in HPV-positive cells compared to both HPV-negative SCCHN and normal oral keratinocytes." -tissue_expression_down hsa-mir-218 Squamous Cell Carcinoma 20652977 "The miRNAs miR-363, miR-33, and miR-497 were upregulated, whereas miR-155, miR-181a, miR-181b, miR-29a, miR-218, miR-222, miR-221, and miR-142-5p were downregulated in HPV-positive cells compared to both HPV-negative SCCHN and normal oral keratinocytes." -tissue_expression_down hsa-mir-221 Squamous Cell Carcinoma 20652977 "The miRNAs miR-363, miR-33, and miR-497 were upregulated, whereas miR-155, miR-181a, miR-181b, miR-29a, miR-218, miR-222, miR-221, and miR-142-5p were downregulated in HPV-positive cells compared to both HPV-negative SCCHN and normal oral keratinocytes." -tissue_expression_down hsa-mir-222 Squamous Cell Carcinoma 20652977 "The miRNAs miR-363, miR-33, and miR-497 were upregulated, whereas miR-155, miR-181a, miR-181b, miR-29a, miR-218, miR-222, miR-221, and miR-142-5p were downregulated in HPV-positive cells compared to both HPV-negative SCCHN and normal oral keratinocytes." -tissue_expression_down hsa-mir-29a Squamous Cell Carcinoma 20652977 "The miRNAs miR-363, miR-33, and miR-497 were upregulated, whereas miR-155, miR-181a, miR-181b, miR-29a, miR-218, miR-222, miR-221, and miR-142-5p were downregulated in HPV-positive cells compared to both HPV-negative SCCHN and normal oral keratinocytes." -tissue_expression_down hsa-mir-218 Astrocytoma 20711171 Inhibition of two glioblastoma-upregulated miRNAs (miR-21 and miR-23a) and exogenous overexpression of two glioblastoma-downregulated miRNAs (miR-218 and miR-219-5p) resulted in reduced soft agar colony formation but showed varying effects on cell proliferation and chemosensitivity. -tissue_expression_down hsa-mir-219 Astrocytoma 20711171 Inhibition of two glioblastoma-upregulated miRNAs (miR-21 and miR-23a) and exogenous overexpression of two glioblastoma-downregulated miRNAs (miR-218 and miR-219-5p) resulted in reduced soft agar colony formation but showed varying effects on cell proliferation and chemosensitivity. -tissue_expression_down hsa-mir-17 Multiple Sclerosis 20711463 "In all MS subtypes miR-17 and miR-20a were significantly under-expressed in MS, confirmed by RT-PCR. " -tissue_expression_down hsa-mir-20a Multiple Sclerosis 20711463 "In all MS subtypes miR-17 and miR-20a were significantly under-expressed in MS, confirmed by RT-PCR. " -tissue_expression_down hsa-mir-145 Ovarian Neoplasms 20716115 "Reduced miR-145 and miR-214 and elevated let-7f, miR-182, miR-210, miR-200c, miR-222 and miR-23a levels were found in effusions in both sets." -tissue_expression_down hsa-mir-214 Ovarian Neoplasms 20716115 "Reduced miR-145 and miR-214 and elevated let-7f, miR-182, miR-210, miR-200c, miR-222 and miR-23a levels were found in effusions in both sets." -tissue_expression_down hsa-mir-126 Breast Neoplasms 20801493 "A high correlation of miRNA expression level was found between breast tumor tissues and sera. MiR-21, miR-106a and miR-155 were significantly over-expressed in the tumor specimens compared with those in normal controls (P < 0.05), whereas miR-126, miR-199a and miR-335 were significantly under-expressed (P < 0.05)." -tissue_expression_down hsa-mir-199a Breast Neoplasms 20801493 "A high correlation of miRNA expression level was found between breast tumor tissues and sera. MiR-21, miR-106a and miR-155 were significantly over-expressed in the tumor specimens compared with those in normal controls (P < 0.05), whereas miR-126, miR-199a and miR-335 were significantly under-expressed (P < 0.05)." -tissue_expression_down hsa-mir-335 Breast Neoplasms 20801493 "A high correlation of miRNA expression level was found between breast tumor tissues and sera. MiR-21, miR-106a and miR-155 were significantly over-expressed in the tumor specimens compared with those in normal controls (P < 0.05), whereas miR-126, miR-199a and miR-335 were significantly under-expressed (P < 0.05)." -tissue_expression_down hsa-mir-1-1 Laryngeal Neoplasms 20806854 downregulated by 5 multiple -tissue_expression_down hsa-mir-1-2 Laryngeal Neoplasms 20806854 downregulated by 5 multiple -tissue_expression_down hsa-mir-133a-1 Laryngeal Neoplasms 20806854 downregulated by 5 multiple -tissue_expression_down hsa-mir-133a-2 Laryngeal Neoplasms 20806854 downregulated by 5 multiple -tissue_expression_down hsa-mir-144 Laryngeal Neoplasms 20806854 downregulated by 5 multiple -tissue_expression_down hsa-mir-206 Laryngeal Neoplasms 20806854 downregulated by 5 multiple -tissue_expression_down hsa-mir-375 Laryngeal Neoplasms 20806854 downregulated by 5 multiple -tissue_expression_down hsa-mir-378a Laryngeal Neoplasms 20806854 downregulated by 5 multiple -tissue_expression_down hsa-mir-384 Laryngeal Neoplasms 20806854 downregulated by 5 multiple -tissue_expression_down hsa-mir-422a Laryngeal Neoplasms 20806854 downregulated by 5 multiple -tissue_expression_down hsa-mir-486 Laryngeal Neoplasms 20806854 miR-486-5p: downregulated by 5 multiple -tissue_expression_down hsa-mir-487a Laryngeal Neoplasms 20806854 downregulated by 5 multiple -tissue_expression_down hsa-mir-21 Spinal Cord Injuries 20816819 "spinal cord injury (SCI)results in increased expression of miR Let-7a and miR16 while exercise leads to elevated levels of miR21 and decreased levels of miR15b. These changes in miR expression are correlated with changes in expression of their target genes: pro-apoptotic (decreased PTEN, PDCD4, and RAS mRNA) and anti-apoptotic (increased Bcl-2 mRNA) target genes. This is accompanied by a down-regulation of mRNA for caspase-7 and caspase-9 and reduced levels of caspase-7 protein." -tissue_expression_down hsa-mir-125b Melanoma 20827223 Downregulation of miR-125b in metastatic cutaneous malignant melanoma. -tissue_expression_down hsa-mir-195 Aortic Insufficiency 20845893 "miR-195:MiR-26a, miR-30b, and miR-195 were each decreased in the aortic valves of patients requiring AVR due to AS, compared to those requiring replacement due to AI." -tissue_expression_down hsa-mir-195 Aortic Stenosis 20845893 "miR-195:MiR-26a, miR-30b, and miR-195 were each decreased in the aortic valves of patients requiring AVR due to AS, compared to those requiring replacement due to AI." -tissue_expression_down hsa-mir-195 Chronic Heart Failure 20845893 "miR-195:MiR-26a, miR-30b, and miR-195 were each decreased in the aortic valves of patients requiring AVR due to AS, compared to those requiring replacement due to AI." -tissue_expression_down hsa-mir-26a-1 Aortic Insufficiency 20845893 "MiR-26a:MiR-26a, miR-30b, and miR-195 were each decreased in the aortic valves of patients requiring AVR due to AS, compared to those requiring replacement due to AI." -tissue_expression_down hsa-mir-26a-1 Aortic Stenosis 20845893 "MiR-26a:MiR-26a, miR-30b, and miR-195 were each decreased in the aortic valves of patients requiring AVR due to AS, compared to those requiring replacement due to AI." -tissue_expression_down hsa-mir-26a-1 Chronic Heart Failure 20845893 "MiR-26a:MiR-26a, miR-30b, and miR-195 were each decreased in the aortic valves of patients requiring AVR due to AS, compared to those requiring replacement due to AI." -tissue_expression_down hsa-mir-26a-2 Aortic Insufficiency 20845893 "MiR-26a:MiR-26a, miR-30b, and miR-195 were each decreased in the aortic valves of patients requiring AVR due to AS, compared to those requiring replacement due to AI." -tissue_expression_down hsa-mir-26a-2 Aortic Stenosis 20845893 "MiR-26a:MiR-26a, miR-30b, and miR-195 were each decreased in the aortic valves of patients requiring AVR due to AS, compared to those requiring replacement due to AI." -tissue_expression_down hsa-mir-26a-2 Chronic Heart Failure 20845893 "MiR-26a:MiR-26a, miR-30b, and miR-195 were each decreased in the aortic valves of patients requiring AVR due to AS, compared to those requiring replacement due to AI." -tissue_expression_down hsa-mir-30b Aortic Insufficiency 20845893 "MiR-30b:MiR-26a, miR-30b, and miR-195 were each decreased in the aortic valves of patients requiring AVR due to AS, compared to those requiring replacement due to AI." -tissue_expression_down hsa-mir-30b Aortic Stenosis 20845893 "MiR-30b:MiR-26a, miR-30b, and miR-195 were each decreased in the aortic valves of patients requiring AVR due to AS, compared to those requiring replacement due to AI." -tissue_expression_down hsa-mir-30b Chronic Heart Failure 20845893 "MiR-30b:MiR-26a, miR-30b, and miR-195 were each decreased in the aortic valves of patients requiring AVR due to AS, compared to those requiring replacement due to AI." -tissue_expression_down hsa-mir-21 Neuroma 20856158 miR-21:Elevated levels of hsa-microRNA-21 (miR-21) in vestibular schwannomas (VSs) may contribute to tumor growth by downregulating the tumor suppressor phosphatase and tensin homolog (PTEN) and consequent hyperactivation of protein kinase B -tissue_expression_down hsa-mir-126 Colon Neoplasms 20859756 "miR-126:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection." -tissue_expression_down hsa-mir-142 Colon Neoplasms 20859756 "miR-142-3p:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection." -tissue_expression_down hsa-mir-146a Colon Neoplasms 20859756 "miR-146a:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection." -tissue_expression_down hsa-mir-152 Colon Neoplasms 20859756 "miR-152:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection." -tissue_expression_down hsa-mir-155 Colon Neoplasms 20859756 "miR-155:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection." -tissue_expression_down hsa-mir-205 Colon Neoplasms 20859756 "miR-205:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection." -tissue_expression_down hsa-mir-365a Colon Neoplasms 20859756 "miR-365:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection." -tissue_expression_down hsa-mir-365b Colon Neoplasms 20859756 "miR-365:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection." -tissue_expression_down hsa-mir-449a Colon Neoplasms 20859756 "miR-449:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection." -tissue_expression_down hsa-mir-518c Colon Neoplasms 20859756 "miR-518c:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection." -tissue_expression_down hsa-mir-552 Colon Neoplasms 20859756 "miR-552:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection." -tissue_expression_down hsa-mir-584 Colon Neoplasms 20859756 "miR-584:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection." -tissue_expression_down hsa-mir-615 Colon Neoplasms 20859756 "miR-615:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection." -tissue_expression_down hsa-mir-622 Colon Neoplasms 20859756 "miR-622:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection." -tissue_expression_down hsa-mir-630 Colon Neoplasms 20859756 "miR-630:In particular, miR-126, miR-142-3p, miR-155, miR-552, and miR-630 were all upregulated, whereas miR-146a, miR-152, miR-205, miR-365, miR-449, miR-518c, miR-584, miR-615, and miR-622 were downregulated after NGX6 transfection." -tissue_expression_down hsa-mir-122 "Carcinoma, Hepatocellular" 20859956 miR-122a:microRNA-122a (miR-122a) is a liver-specific miRNA that is frequently downregulated in hepatocellular carcinoma (HCC) -tissue_expression_down hsa-mir-106b Prostate Neoplasms 20878953 Down-regulation of microRNA 106b is involved in p21-mediated cell cycle arrest in response to radiation in prostate cancer cells. -tissue_expression_down hsa-mir-135a "Carcinoma, Rectal" 20955366 The miR-135a&b were the miRNAs most down-regulated by CM-1. -tissue_expression_down hsa-mir-135b "Carcinoma, Rectal" 20955366 The miR-135a&b were the miRNAs most down-regulated by CM-1. -tissue_expression_down hsa-mir-122 "Fatty Liver, Non-Alcoholic" 20956972 "The miRNAs analysis showed the significant downregulation of three miRNAs (miR-122, miR-451 and miR-27) and the upregulation of miR-200a, miR-200b and miR-429 in HFD, SD-HF and HFD-HF rats" -tissue_expression_down hsa-mir-21 "Fatty Liver, Non-Alcoholic" 20956972 "Besides, miR-21 expression was significantly decreased only in fructose-enriched diets." -tissue_expression_down hsa-mir-27 "Fatty Liver, Non-Alcoholic" 20956972 "The miRNAs analysis showed the significant downregulation of three miRNAs (miR-122, miR-451 and miR-27) and the upregulation of miR-200a, miR-200b and miR-429 in HFD, SD-HF and HFD-HF rats" -tissue_expression_down hsa-mir-451 "Fatty Liver, Non-Alcoholic" 20956972 "The miRNAs analysis showed the significant downregulation of three miRNAs (miR-122, miR-451 and miR-27) and the upregulation of miR-200a, miR-200b and miR-429 in HFD, SD-HF and HFD-HF rats" -tissue_expression_down hsa-mir-15a Lymphoma 21118128 "Both decreased expression of miR-15a and miR-16-1 and increased nucleolin have been shown to be associated with increased Bcl2 expression and resistance to apoptosis in the common human disease, chronic lymphocytic leukaemia." -tissue_expression_down hsa-mir-16-1 Lymphoma 21118128 "Both decreased expression of miR-15a and miR-16-1 and increased nucleolin have been shown to be associated with increased Bcl2 expression and resistance to apoptosis in the common human disease, chronic lymphocytic leukaemia." -tissue_expression_down hsa-mir-221 Gastrointestinal Neoplasms 21132270 Down-regulation of miR-221 and miR-222 correlates with pronounced Kit expression in gastrointestinal stromal tumors -tissue_expression_down hsa-mir-222 Gastrointestinal Neoplasms 21132270 Down-regulation of miR-221 and miR-222 correlates with pronounced Kit expression in gastrointestinal stromal tumors -tissue_expression_down hsa-mir-145 Hepatoblastoma 21145831 downregulated in early stages of HBV-associated multistep hepatocarcinogenesis. -tissue_expression_down hsa-mir-199b Hepatoblastoma 21145831 downregulated in early stages of HBV-associated multistep hepatocarcinogenesis. -tissue_expression_down hsa-mir-29b-1 Myotonic Muscular Dystrophy 21169019 "We found that miR-1 and miR-335 were up-regulated, whereas miR-29b and c, and miR-33 were down-regulated in DM1 biopsies compared to controls." -tissue_expression_down hsa-mir-29b-2 Myotonic Muscular Dystrophy 21169019 "We found that miR-1 and miR-335 were up-regulated, whereas miR-29b and c, and miR-33 were down-regulated in DM1 biopsies compared to controls." -tissue_expression_down hsa-mir-29c Myotonic Muscular Dystrophy 21169019 "We found that miR-1 and miR-335 were up-regulated, whereas miR-29b and c, and miR-33 were down-regulated in DM1 biopsies compared to controls." -tissue_expression_down hsa-mir-33a Myotonic Muscular Dystrophy 21169019 "We found that miR-1 and miR-335 were up-regulated, whereas miR-29b and c, and miR-33 were down-regulated in DM1 biopsies compared to controls." -tissue_expression_down hsa-mir-33b Myotonic Muscular Dystrophy 21169019 "We found that miR-1 and miR-335 were up-regulated, whereas miR-29b and c, and miR-33 were down-regulated in DM1 biopsies compared to controls." -tissue_expression_down hsa-mir-342 Breast Neoplasms 21172025 Downregulation of miR-342 is Associated with Tamoxifen Resistant Breast Tumors. -tissue_expression_down hsa-mir-148b Liver Neoplasms 21176238 mir-148b* is underexpressed in side population of HCC cells compared to fetal liver cells -tissue_expression_down hsa-mir-200a Liver Neoplasms 21176238 mir-200a* is underexpressed in side population of HCC cells compared to fetal liver cells -tissue_expression_down hsa-mir-21 Prostate Neoplasms 21177307 "We also observed a significant down-regulation of androgen-regulated miRNA-21 and up-regulation of a tumor suppressor, miRNA-330, in tumors of mice treated with EGCG" -tissue_expression_down hsa-mir-124-2 Glioblastoma 21196113 miR-124a is frequently down-regulated in glioblastoma and is involved in migration and invasion. -tissue_expression_down hsa-mir-148b Gastric Neoplasms 21205300 MicroRNA-148b is frequently down-regulated in gastric cancer and acts as a tumor suppressor by inhibiting cell proliferation. -tissue_expression_down hsa-mir-143 Glioblastoma 21211035 "down regulation of miR-143, -145, -253-5p and miR-452 by SOX2" -tissue_expression_down hsa-mir-145 Glioblastoma 21211035 "down regulation of miR-143, -145, -253-5p and miR-452 by SOX2" -tissue_expression_down hsa-mir-452 Glioblastoma 21211035 "down regulation of miR-143, -145, -253-5p and miR-452 by SOX2" -tissue_expression_down hsa-mir-146a Myelodysplastic Syndromes 21211043 miR-378 and miR-146a showed reduced gene expression in the patients. -tissue_expression_down hsa-mir-378a Myelodysplastic Syndromes 21211043 miR-378 and miR-146a showed reduced gene expression in the patients. -tissue_expression_down hsa-mir-143 Esophageal Neoplasms 21218087 MiRNA profile in esophageal squamous cell carcinoma: Downregulation of miR-143 and miR-145. -tissue_expression_down hsa-mir-145 Esophageal Neoplasms 21218087 MiRNA profile in esophageal squamous cell carcinoma: Downregulation of miR-143 and miR-145. -tissue_expression_down hsa-mir-300 Urinary Bladder Cancer 21223810 "In grade I, grade II, grade III, grade I + II + III, infiltrating and non-infiltrating groups, hsa-miR-29b-1* was up-regulated while hsa-miR-923 and hsa-miR-300 were down-regulated" -tissue_expression_down hsa-mir-135b "Squamous Cell Carcinoma, Oral" 21244772 "Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours." -tissue_expression_down hsa-mir-197 "Squamous Cell Carcinoma, Oral" 21244772 "Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours." -tissue_expression_down hsa-mir-224 "Squamous Cell Carcinoma, Oral" 21244772 "Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours." -tissue_expression_down hsa-mir-34a "Squamous Cell Carcinoma, Oral" 21244772 "Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours." -tissue_expression_down hsa-mir-378a "Squamous Cell Carcinoma, Oral" 21244772 "Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours." -tissue_expression_down hsa-mir-520h "Squamous Cell Carcinoma, Oral" 21244772 "Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours." -tissue_expression_down hsa-mir-518b Esophageal Neoplasms 21269950 hsa-mir-126 is upregulated and hsa-miR-518b is downregulated in esophageal squamous carcinoma -tissue_expression_down hsa-mir-181a-1 "Squamous Cell Carcinoma, Head and Neck" 21274007 "deltaNp63alpha-dependent miRNA miR-181a, miR-519a, and miR-374a downregulation in HNSCC,miR-630 upregulation in HNSCC" -tissue_expression_down hsa-mir-181a-2 "Squamous Cell Carcinoma, Head and Neck" 21274007 "deltaNp63alpha-dependent miRNA miR-181a, miR-519a, and miR-374a downregulation in HNSCC,miR-630 upregulation in HNSCC" -tissue_expression_down hsa-mir-519a-1 "Squamous Cell Carcinoma, Head and Neck" 21274007 "deltaNp63alpha-dependent miRNA miR-181a, miR-519a, and miR-374a downregulation in HNSCC,miR-630 upregulation in HNSCC" -tissue_expression_down hsa-mir-519a-2 "Squamous Cell Carcinoma, Head and Neck" 21274007 "deltaNp63alpha-dependent miRNA miR-181a, miR-519a, and miR-374a downregulation in HNSCC,miR-630 upregulation in HNSCC" -tissue_expression_down hsa-mir-141 Learned Helplessness 21275079 "mir-96, 141, 182, 183, 183*, 298, 200a, 200a*, 200b, 200b*, 200c, 429 are significantly downregulated in non-learned helplessness relative to tested controls in rat brain." -tissue_expression_down hsa-mir-182 Learned Helplessness 21275079 "mir-96, 141, 182, 183, 183*, 298, 200a, 200a*, 200b, 200b*, 200c, 429 are significantly downregulated in non-learned helplessness relative to tested controls in rat brain." -tissue_expression_down hsa-mir-183 Learned Helplessness 21275079 "mir-96, 141, 182, 183, 183*, 298, 200a, 200a*, 200b, 200b*, 200c, 429 are significantly downregulated in non-learned helplessness relative to tested controls in rat brain." -tissue_expression_down hsa-mir-200a Learned Helplessness 21275079 "mir-96, 141, 182, 183, 183*, 298, 200a, 200a*, 200b, 200b*, 200c, 429 are significantly downregulated in non-learned helplessness relative to tested controls in rat brain." -tissue_expression_down hsa-mir-200b Learned Helplessness 21275079 "mir-96, 141, 182, 183, 183*, 298, 200a, 200a*, 200b, 200b*, 200c, 429 are significantly downregulated in non-learned helplessness relative to tested controls in rat brain." -tissue_expression_down hsa-mir-200c Learned Helplessness 21275079 "mir-96, 141, 182, 183, 183*, 298, 200a, 200a*, 200b, 200b*, 200c, 429 are significantly downregulated in non-learned helplessness relative to tested controls in rat brain." -tissue_expression_down hsa-mir-429 Learned Helplessness 21275079 "mir-96, 141, 182, 183, 183*, 298, 200a, 200a*, 200b, 200b*, 200c, 429 are significantly downregulated in non-learned helplessness relative to tested controls in rat brain." -tissue_expression_down hsa-mir-96 Learned Helplessness 21275079 "mir-96, 141, 182, 183, 183*, 298, 200a, 200a*, 200b, 200b*, 200c, 429 are significantly downregulated in non-learned helplessness relative to tested controls in rat brain." -tissue_expression_down hsa-let-7g Gastrointestinal Neoplasms 21293479 "In the HCPT-resistant gastric cancer cells, the levels of 25 miRNAs were deregulated, including miR-196a, miR-200 family, miR-338, miR-126, miR-31, miR-98, let-7g, and miR-7." -tissue_expression_down hsa-mir-126 Gastrointestinal Neoplasms 21293479 "In the HCPT-resistant gastric cancer cells, the levels of 25 miRNAs were deregulated, including miR-196a, miR-200 family, miR-338, miR-126, miR-31, miR-98, let-7g, and miR-7." -tissue_expression_down hsa-mir-196a-1 Gastrointestinal Neoplasms 21293479 "In the HCPT-resistant gastric cancer cells, the levels of 25 miRNAs were deregulated, including miR-196a, miR-200 family, miR-338, miR-126, miR-31, miR-98, let-7g, and miR-7." -tissue_expression_down hsa-mir-196a-2 Gastrointestinal Neoplasms 21293479 "In the HCPT-resistant gastric cancer cells, the levels of 25 miRNAs were deregulated, including miR-196a, miR-200 family, miR-338, miR-126, miR-31, miR-98, let-7g, and miR-7." -tissue_expression_down hsa-mir-200a Gastrointestinal Neoplasms 21293479 "In the HCPT-resistant gastric cancer cells, the levels of 25 miRNAs were deregulated, including miR-196a, miR-200 family, miR-338, miR-126, miR-31, miR-98, let-7g, and miR-7." -tissue_expression_down hsa-mir-200b Gastrointestinal Neoplasms 21293479 "In the HCPT-resistant gastric cancer cells, the levels of 25 miRNAs were deregulated, including miR-196a, miR-200 family, miR-338, miR-126, miR-31, miR-98, let-7g, and miR-7." -tissue_expression_down hsa-mir-200c Gastrointestinal Neoplasms 21293479 "In the HCPT-resistant gastric cancer cells, the levels of 25 miRNAs were deregulated, including miR-196a, miR-200 family, miR-338, miR-126, miR-31, miR-98, let-7g, and miR-7." -tissue_expression_down hsa-mir-31 Gastrointestinal Neoplasms 21293479 "In the HCPT-resistant gastric cancer cells, the levels of 25 miRNAs were deregulated, including miR-196a, miR-200 family, miR-338, miR-126, miR-31, miR-98, let-7g, and miR-7." -tissue_expression_down hsa-mir-338 Gastrointestinal Neoplasms 21293479 "In the HCPT-resistant gastric cancer cells, the levels of 25 miRNAs were deregulated, including miR-196a, miR-200 family, miR-338, miR-126, miR-31, miR-98, let-7g, and miR-7." -tissue_expression_down hsa-mir-7-1 Gastrointestinal Neoplasms 21293479 "In the HCPT-resistant gastric cancer cells, the levels of 25 miRNAs were deregulated, including miR-196a, miR-200 family, miR-338, miR-126, miR-31, miR-98, let-7g, and miR-7." -tissue_expression_down hsa-mir-7-2 Gastrointestinal Neoplasms 21293479 "In the HCPT-resistant gastric cancer cells, the levels of 25 miRNAs were deregulated, including miR-196a, miR-200 family, miR-338, miR-126, miR-31, miR-98, let-7g, and miR-7." -tissue_expression_down hsa-mir-7-3 Gastrointestinal Neoplasms 21293479 "In the HCPT-resistant gastric cancer cells, the levels of 25 miRNAs were deregulated, including miR-196a, miR-200 family, miR-338, miR-126, miR-31, miR-98, let-7g, and miR-7." -tissue_expression_down hsa-mir-98 Gastrointestinal Neoplasms 21293479 "In the HCPT-resistant gastric cancer cells, the levels of 25 miRNAs were deregulated, including miR-196a, miR-200 family, miR-338, miR-126, miR-31, miR-98, let-7g, and miR-7." -tissue_expression_down hsa-mir-218-1 "Carcinoma, Cervical" 21309487 infection with high-risk HPV lowered the expression of miR-218 and that down-regulation of miR-218 was involved in the pathogenesis of cervical cancer -tissue_expression_down hsa-mir-218-2 "Carcinoma, Cervical" 21309487 infection with high-risk HPV lowered the expression of miR-218 and that down-regulation of miR-218 was involved in the pathogenesis of cervical cancer -tissue_expression_down hsa-mir-30c-1 Mesothelioma 21317924 Hsa-miR-17* was significantly upregulated and hsa-miR-30c was significantly downregulated by Onconase treatment in all cell lines -tissue_expression_down hsa-mir-30c-2 Mesothelioma 21317924 Hsa-miR-17* was significantly upregulated and hsa-miR-30c was significantly downregulated by Onconase treatment in all cell lines -tissue_expression_down hsa-mir-34c Ovarian Neoplasms 21321636 "miR-449b and miR-34c on inducing down-regulation of cell cycle-related proteins and cycle arrests in SKOV3-ipl cell, an ovarian cancer cell line." -tissue_expression_down hsa-mir-499a Ovarian Neoplasms 21321636 "miR-449b and miR-34c on inducing down-regulation of cell cycle-related proteins and cycle arrests in SKOV3-ipl cell, an ovarian cancer cell line." -tissue_expression_down hsa-mir-34b Lung Neoplasms 21339737 "A microRNA, miR-34b, that suppresses the expression of alpha4 through specific binding to the 3'-untranslated region of alpha4 is downregulated in transformed or human lung tumors." -tissue_expression_down hsa-mir-200c Ovarian Neoplasms 21345725 "miR-200c has potential as a predictor of survival, and is a biomarker of relapse, in stage I EOC." -tissue_expression_down hsa-mir-146a Gastrointestinal Neoplasms 21347720 MicroRNA-146a is down-regulated in gastric cancer and regulates cell proliferation and apoptosis. -tissue_expression_down hsa-mir-34c Prostate Neoplasms 21351256 miR-34c is downregulated in prostate cancer and exerts tumor suppressive functions. -tissue_expression_down hsa-mir-21 Psoriasis 21373745 "Real-time PCR and immunohistochemistry showed that p63 expression was not significantly affected, whereas NB-UVB phototherapy significantly decreased expression ofmiR-21 (p = 0.003) and increased miR-125b levels (p = 0.003). The results indicate that the unresolved p63 abnormality in treated epidermis may play a role in maintenance of this disease." -tissue_expression_down hsa-let-7a-1 Nasopharyngeal Neoplasms 21373758 underexpressed -tissue_expression_down hsa-let-7a-2 Nasopharyngeal Neoplasms 21373758 underexpressed -tissue_expression_down hsa-let-7a-3 Nasopharyngeal Neoplasms 21373758 underexpressed -tissue_expression_down hsa-let-7b Nasopharyngeal Neoplasms 21373758 underexpressed -tissue_expression_down hsa-let-7c Nasopharyngeal Neoplasms 21373758 underexpressed -tissue_expression_down hsa-let-7d Nasopharyngeal Neoplasms 21373758 underexpressed -tissue_expression_down hsa-let-7e Nasopharyngeal Neoplasms 21373758 underexpressed -tissue_expression_down hsa-let-7f-1 Nasopharyngeal Neoplasms 21373758 underexpressed -tissue_expression_down hsa-let-7f-2 Nasopharyngeal Neoplasms 21373758 underexpressed -tissue_expression_down hsa-let-7g Nasopharyngeal Neoplasms 21373758 underexpressed -tissue_expression_down hsa-let-7i Nasopharyngeal Neoplasms 21373758 underexpressed -tissue_expression_down hsa-mir-34b Nasopharyngeal Neoplasms 21373758 underexpressed -tissue_expression_down hsa-mir-34c Nasopharyngeal Neoplasms 21373758 underexpressed -tissue_expression_down hsa-mir-221 Prostate Neoplasms 21378318 miR-221 Is Down-regulated in TMPRSS2:ERG Fusion-positive Prostate Cancer. -tissue_expression_down hsa-mir-222 Prostate Neoplasms 21378318 miR-221 Is Down-regulated in TMPRSS2:ERG Fusion-positive Prostate Cancer. -tissue_expression_down hsa-mir-99a Neoplasms [unspecific] 21383697 miR-99a-mediated downregulation of mTOR/FGFR3 controls tumor growth induced by Src-related oncogenic pathways. -tissue_expression_down hsa-mir-181a-1 Systemic Lupus Erythematosus 21385555 miR-181-a was significantly downregulated in SLE pediatrics as compared to healthy controls. -tissue_expression_down hsa-mir-181a-2 Systemic Lupus Erythematosus 21385555 miR-181-a was significantly downregulated in SLE pediatrics as compared to healthy controls. -tissue_expression_down hsa-mir-195 Colorectal Carcinoma 21390519 Downregulation of miR-195 correlates with lymph node metastasis and poor prognosis in colorectal cancer. -tissue_expression_down hsa-mir-1-1 Hypertrophy 21418519 IGF-1 deficiency retards AAC-induced cardiac hypertrophic and contractile changes via alleviating downregulation of miR-1 and miR-133a in response to left ventricular pressure overload. -tissue_expression_down hsa-mir-1-2 Hypertrophy 21418519 IGF-1 deficiency retards AAC-induced cardiac hypertrophic and contractile changes via alleviating downregulation of miR-1 and miR-133a in response to left ventricular pressure overload. -tissue_expression_down hsa-mir-133a-1 Hypertrophy 21418519 IGF-1 deficiency retards AAC-induced cardiac hypertrophic and contractile changes via alleviating downregulation of miR-1 and miR-133a in response to left ventricular pressure overload. -tissue_expression_down hsa-mir-133a-2 Hypertrophy 21418519 IGF-1 deficiency retards AAC-induced cardiac hypertrophic and contractile changes via alleviating downregulation of miR-1 and miR-133a in response to left ventricular pressure overload. -tissue_expression_down hsa-mir-449a Gastric Neoplasms 21418558 miR-449 inhibits cell proliferation and is down-regulated in gastric cancer. -tissue_expression_down hsa-mir-449b Gastric Neoplasms 21418558 miR-449 inhibits cell proliferation and is down-regulated in gastric cancer. -tissue_expression_down hsa-mir-449c Gastric Neoplasms 21418558 miR-449 inhibits cell proliferation and is down-regulated in gastric cancer. -tissue_expression_down hsa-mir-10a Endometriosis 21436257 down-regulated in endometriomas compared with endometrium. -tissue_expression_down hsa-mir-141 Endometriosis 21436257 down-regulated in endometriomas compared with endometrium. -tissue_expression_down hsa-mir-200a Endometriosis 21436257 down-regulated in endometriomas compared with endometrium. -tissue_expression_down hsa-mir-200b Endometriosis 21436257 down-regulated in endometriomas compared with endometrium. -tissue_expression_down hsa-mir-200c Endometriosis 21436257 down-regulated in endometriomas compared with endometrium. -tissue_expression_down hsa-mir-203 Endometriosis 21436257 down-regulated in endometriomas compared with endometrium. -tissue_expression_down hsa-mir-34c Endometriosis 21436257 miR-34c-5p down-regulated in endometriomas compared with endometrium. -tissue_expression_down hsa-mir-375 Endometriosis 21436257 down-regulated in endometriomas compared with endometrium. -tissue_expression_down hsa-mir-429 Endometriosis 21436257 down-regulated in endometriomas compared with endometrium. -tissue_expression_down hsa-mir-449b Endometriosis 21436257 down-regulated in endometriomas compared with endometrium. -tissue_expression_down hsa-mir-504 Endometriosis 21436257 down-regulated in endometriomas compared with endometrium. -tissue_expression_down hsa-mir-873 Endometriosis 21436257 down-regulated in endometriomas compared with endometrium. -tissue_expression_down hsa-mir-141 Barrett Esophagus 21448356 miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus. -tissue_expression_down hsa-mir-200a Barrett Esophagus 21448356 miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus. -tissue_expression_down hsa-mir-200b Barrett Esophagus 21448356 miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus. -tissue_expression_down hsa-mir-200c Barrett Esophagus 21448356 miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus. -tissue_expression_down hsa-mir-429 Barrett Esophagus 21448356 miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus. -tissue_expression_down hsa-mir-125b-1 Melanoma 21460750 the expression of miRNA-125b (miR-125b) was two-fold lower in malignant melanoma producing lymph node micrometastases than in nonmetastasizing tumors. MicroRNA miR-125b induces senescence in human melanoma cells.We propose that downregulation of miR-125b in an early cutaneous malignant melanoma can contribute to the increased metastatic capability of this tumor. -tissue_expression_down hsa-mir-125b-2 Melanoma 21460750 the expression of miRNA-125b (miR-125b) was two-fold lower in malignant melanoma producing lymph node micrometastases than in nonmetastasizing tumors. MicroRNA miR-125b induces senescence in human melanoma cells.We propose that downregulation of miR-125b in an early cutaneous malignant melanoma can contribute to the increased metastatic capability of this tumor. -tissue_expression_down hsa-let-7a-1 Pancreatic Neoplasms 21463919 "over-expression of Notch-1 leads to increased expression of miR-21, and decreased expression of miR-200b, miR-200c, let-7a, let-7b, and let-7c. over-expression of Notch-1 led to the induction of EMT phenotype" -tissue_expression_down hsa-let-7a-2 Pancreatic Neoplasms 21463919 "over-expression of Notch-1 leads to increased expression of miR-21, and decreased expression of miR-200b, miR-200c, let-7a, let-7b, and let-7c. over-expression of Notch-1 led to the induction of EMT phenotype" -tissue_expression_down hsa-let-7a-3 Pancreatic Neoplasms 21463919 "over-expression of Notch-1 leads to increased expression of miR-21, and decreased expression of miR-200b, miR-200c, let-7a, let-7b, and let-7c. over-expression of Notch-1 led to the induction of EMT phenotype" -tissue_expression_down hsa-let-7b Pancreatic Neoplasms 21463919 "over-expression of Notch-1 leads to increased expression of miR-21, and decreased expression of miR-200b, miR-200c, let-7a, let-7b, and let-7c. over-expression of Notch-1 led to the induction of EMT phenotype" -tissue_expression_down hsa-let-7c Pancreatic Neoplasms 21463919 "over-expression of Notch-1 leads to increased expression of miR-21, and decreased expression of miR-200b, miR-200c, let-7a, let-7b, and let-7c. over-expression of Notch-1 led to the induction of EMT phenotype" -tissue_expression_down hsa-mir-200b Pancreatic Neoplasms 21463919 "over-expression of Notch-1 leads to increased expression of miR-21, and decreased expression of miR-200b, miR-200c, let-7a, let-7b, and let-7c. over-expression of Notch-1 led to the induction of EMT phenotype" -tissue_expression_down hsa-mir-200c Pancreatic Neoplasms 21463919 "over-expression of Notch-1 leads to increased expression of miR-21, and decreased expression of miR-200b, miR-200c, let-7a, let-7b, and let-7c. over-expression of Notch-1 led to the induction of EMT phenotype" -tissue_expression_down hsa-mir-143 Urinary Bladder Cancer 21464941 "Compared to matched histologically normal urothelium, downregulated." -tissue_expression_down hsa-mir-145 Urinary Bladder Cancer 21464941 "Compared to matched histologically normal urothelium, downregulated." -tissue_expression_down hsa-let-7a-1 "Carcinoma, Lung, Non-Small-Cell" 21468581 "Let-7a miRNAs were under-expressed in the blood of NSCLC patients, as well as NSCLC cells and NSCLC tissues, compared to normal controls." -tissue_expression_down hsa-let-7a-2 "Carcinoma, Lung, Non-Small-Cell" 21468581 "Let-7a miRNAs were under-expressed in the blood of NSCLC patients, as well as NSCLC cells and NSCLC tissues, compared to normal controls." -tissue_expression_down hsa-let-7a-3 "Carcinoma, Lung, Non-Small-Cell" 21468581 "Let-7a miRNAs were under-expressed in the blood of NSCLC patients, as well as NSCLC cells and NSCLC tissues, compared to normal controls." -tissue_expression_down hsa-mir-125b-1 "Carcinoma, Adrenocortical" 21472710 "miRs -100, -125b, and -195 were significantly down-regulated, whereas miR-483-5p was significantly up-regulated in malignant as compared with benign tumors." -tissue_expression_down hsa-mir-125b-2 "Carcinoma, Adrenocortical" 21472710 "miRs -100, -125b, and -195 were significantly down-regulated, whereas miR-483-5p was significantly up-regulated in malignant as compared with benign tumors." -tissue_expression_down hsa-mir-195 "Carcinoma, Adrenocortical" 21472710 "miRs -100, -125b, and -195 were significantly down-regulated, whereas miR-483-5p was significantly up-regulated in malignant as compared with benign tumors." -tissue_expression_down hsa-mir-20a Glioblastoma 21483847 "miR-20a upregulated in Glioblastoma vs Normal. Ten miRNAs (miR-20a, miR-106a, miR-17-5p, miR-31, miR-222, miR-148a, miR-221, miR-146b, miR-200b, and miR-193a) could be a signature predicding survival in Glioblastoma." -tissue_expression_down hsa-mir-221 Glioblastoma 21483847 "miR-221 downregulated in Glioblastoma vs Normal. Ten miRNAs (miR-20a, miR-106a, miR-17-5p, miR-31, miR-222, miR-148a, miR-221, miR-146b, miR-200b, and miR-193a) could be a signature predicding survival in Glioblastoma." -tissue_expression_down hsa-mir-222 Glioblastoma 21483847 "miR-222 downregulated in Glioblastoma vs Normal. Ten miRNAs (miR-20a, miR-106a, miR-17-5p, miR-31, miR-222, miR-148a, miR-221, miR-146b, miR-200b, and miR-193a) could be a signature predicding survival in Glioblastoma." -tissue_expression_down hsa-mir-31 Glioblastoma 21483847 "miR-31 downregulated in Glioblastoma vs Normal. Ten miRNAs (miR-20a, miR-106a, miR-17-5p, miR-31, miR-222, miR-148a, miR-221, miR-146b, miR-200b, and miR-193a) could be a signature predicding survival in Glioblastoma." -tissue_expression_down hsa-mir-145 Melanoma 21509659 significantly down-regulated in uveal melanomas compared with normal uveal tissues -tissue_expression_down hsa-mir-204 Melanoma 21509659 significantly down-regulated in uveal melanomas compared with normal uveal tissues -tissue_expression_down hsa-mir-15a Prostate Neoplasms 21532615 miR-15 and miR-16 are downregulated in fibroblasts surrounding the prostate tumors of the majority of 23 patients analyzed. -tissue_expression_down hsa-mir-15b Prostate Neoplasms 21532615 miR-15 and miR-16 are downregulated in fibroblasts surrounding the prostate tumors of the majority of 23 patients analyzed. -tissue_expression_down hsa-mir-16-1 Prostate Neoplasms 21532615 miR-15 and miR-16 are downregulated in fibroblasts surrounding the prostate tumors of the majority of 23 patients analyzed. -tissue_expression_down hsa-mir-16-2 Prostate Neoplasms 21532615 miR-15 and miR-16 are downregulated in fibroblasts surrounding the prostate tumors of the majority of 23 patients analyzed. -tissue_expression_down hsa-mir-1-1 Thyroid Neoplasms 21537871 "miR-146b, miR-221, miR-222, miR-155, miR-31 upregulation and miR-1, miR-34b, miR-130b, miR-138 downregulation in aggressive compared with nonaggressive PTC." -tissue_expression_down hsa-mir-1-2 Thyroid Neoplasms 21537871 "miR-146b, miR-221, miR-222, miR-155, miR-31 upregulation and miR-1, miR-34b, miR-130b, miR-138 downregulation in aggressive compared with nonaggressive PTC." -tissue_expression_down hsa-mir-133b Thyroid Neoplasms 21537871 "miR-146b, miR-221, miR-222, miR-155, miR-31 upregulation and miR-1, miR-34b, miR-130b, miR-138 downregulation in aggressive compared with nonaggressive PTC." -tissue_expression_down hsa-mir-138-1 Thyroid Neoplasms 21537871 "miR-146b, miR-221, miR-222, miR-155, miR-31 upregulation and miR-1, miR-34b, miR-130b, miR-138 downregulation in aggressive compared with nonaggressive PTC." -tissue_expression_down hsa-mir-138-2 Thyroid Neoplasms 21537871 "miR-146b, miR-221, miR-222, miR-155, miR-31 upregulation and miR-1, miR-34b, miR-130b, miR-138 downregulation in aggressive compared with nonaggressive PTC." -tissue_expression_down hsa-mir-34b Thyroid Neoplasms 21537871 "miR-146b, miR-221, miR-222, miR-155, miR-31 upregulation and miR-1, miR-34b, miR-130b, miR-138 downregulation in aggressive compared with nonaggressive PTC." -tissue_expression_down hsa-let-7a-1 "Carcinoma, Lung, Non-Small-Cell" 21544802 "The expression of miR-146b, miR-221, let-7a, miR-155, miR-17-5p, miR-27a and miR-106a were significantly reduced in the serum of NSCLC cases while miR-29c was significantly increased." -tissue_expression_down hsa-let-7a-2 "Carcinoma, Lung, Non-Small-Cell" 21544802 "The expression of miR-146b, miR-221, let-7a, miR-155, miR-17-5p, miR-27a and miR-106a were significantly reduced in the serum of NSCLC cases while miR-29c was significantly increased." -tissue_expression_down hsa-let-7a-3 "Carcinoma, Lung, Non-Small-Cell" 21544802 "The expression of miR-146b, miR-221, let-7a, miR-155, miR-17-5p, miR-27a and miR-106a were significantly reduced in the serum of NSCLC cases while miR-29c was significantly increased." -tissue_expression_down hsa-let-7b "Carcinoma, Lung, Non-Small-Cell" 21544802 Reduced plasma expression of let-7b was modestly associated with worse cancer-specific mortality in all patients and reduced serum expression of miR-223 was modestly associated with cancer-specific mortality in stage IA/B patients. -tissue_expression_down hsa-mir-143 Colorectal Carcinoma 21551242 "MiR-20a and miR-31 were found to be significantly upregulated in more than one study, and miR-143 and miR-145 were found to be significantly downregulated in CRC tissue in six or more studies." -tissue_expression_down hsa-mir-145 Colorectal Carcinoma 21551242 "MiR-20a and miR-31 were found to be significantly upregulated in more than one study, and miR-143 and miR-145 were found to be significantly downregulated in CRC tissue in six or more studies." -tissue_expression_down hsa-mir-143 "Colitis, Ulcerative" 21557394 miR-143 and miR-145 are downregulated in ulcerative colitis -tissue_expression_down hsa-mir-145 "Colitis, Ulcerative" 21557394 miR-143 and miR-145 are downregulated in ulcerative colitis -tissue_expression_down hsa-mir-199b "Carcinoma, Hepatocellular" 21557766 "hsa-mir-199b-5p: Patients with lower levels of miR-199b expression had poorer overall survival and progression-free survival rates, whereas patients with higher levels of miR-199b expression had better survival." -tissue_expression_down hsa-mir-34b Parkinson Disease 21558425 "This miRNA was downregulated in brain areas with variable neuropathological affectation at clinical (motor) stages (Braak stages 4 and 5) of the disease,including the amygdala, frontal cortex, substantia nigra and cerebellum. This miRNA modulate mitochondrial function." -tissue_expression_down hsa-mir-34c Parkinson Disease 21558425 "This miRNA was downregulated in brain areas with variable neuropathological affectation at clinical (motor) stages (Braak stages 4 and 5) of the disease,including the amygdala, frontal cortex, substantia nigra and cerebellum. This miRNA modulate mitochondrial function." -tissue_expression_down hsa-mir-100 Head And Neck Neoplasms 21560177 "Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01)." -tissue_expression_down hsa-mir-100 "Squamous Cell Carcinoma, Head and Neck" 21560177 "Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01)." -tissue_expression_down hsa-mir-130a Head And Neck Neoplasms 21560177 "Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01)." -tissue_expression_down hsa-mir-130a "Squamous Cell Carcinoma, Head and Neck" 21560177 "Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01)." -tissue_expression_down hsa-mir-197 Head And Neck Neoplasms 21560177 "Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01)." -tissue_expression_down hsa-mir-197 "Squamous Cell Carcinoma, Head and Neck" 21560177 "Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01)." -tissue_expression_down hsa-mir-1224 Lung Neoplasms 21563230 "Specifically, thirteen novel asbestos-related miRNAs (over-expressed: miR-148b, miR-374a, miR-24-1*, Let-7d, Let-7e, miR-199b-5p, miR-331-3p, and miR-96 and under-expressed: miR-939, miR-671-5p, miR-605, miR-1224-5p and miR-202) and inversely correlated target genes (e.g., GADD45A, LTBP1, FOSB, NCALD, CACNA2D2, MTSS1, EPB41L3) were identified. " -tissue_expression_down hsa-mir-202 Lung Neoplasms 21563230 "Specifically, thirteen novel asbestos-related miRNAs (over-expressed: miR-148b, miR-374a, miR-24-1*, Let-7d, Let-7e, miR-199b-5p, miR-331-3p, and miR-96 and under-expressed: miR-939, miR-671-5p, miR-605, miR-1224-5p and miR-202) and inversely correlated target genes (e.g., GADD45A, LTBP1, FOSB, NCALD, CACNA2D2, MTSS1, EPB41L3) were identified. " -tissue_expression_down hsa-mir-605 Lung Neoplasms 21563230 "Specifically, thirteen novel asbestos-related miRNAs (over-expressed: miR-148b, miR-374a, miR-24-1*, Let-7d, Let-7e, miR-199b-5p, miR-331-3p, and miR-96 and under-expressed: miR-939, miR-671-5p, miR-605, miR-1224-5p and miR-202) and inversely correlated target genes (e.g., GADD45A, LTBP1, FOSB, NCALD, CACNA2D2, MTSS1, EPB41L3) were identified. " -tissue_expression_down hsa-mir-671 Lung Neoplasms 21563230 "Specifically, thirteen novel asbestos-related miRNAs (over-expressed: miR-148b, miR-374a, miR-24-1*, Let-7d, Let-7e, miR-199b-5p, miR-331-3p, and miR-96 and under-expressed: miR-939, miR-671-5p, miR-605, miR-1224-5p and miR-202) and inversely correlated target genes (e.g., GADD45A, LTBP1, FOSB, NCALD, CACNA2D2, MTSS1, EPB41L3) were identified. " -tissue_expression_down hsa-mir-939 Lung Neoplasms 21563230 "Specifically, thirteen novel asbestos-related miRNAs (over-expressed: miR-148b, miR-374a, miR-24-1*, Let-7d, Let-7e, miR-199b-5p, miR-331-3p, and miR-96 and under-expressed: miR-939, miR-671-5p, miR-605, miR-1224-5p and miR-202) and inversely correlated target genes (e.g., GADD45A, LTBP1, FOSB, NCALD, CACNA2D2, MTSS1, EPB41L3) were identified. " -tissue_expression_down hsa-mir-133b Colorectal Carcinoma 21573504 "High expression of miR-185 and low expression of miR-133b were correlated with poor survival (p=0.001 and 0.028, respectively) and metastasis (p=0.007 and 0.036, respectively) in colorectal cancer." -tissue_expression_down hsa-mir-17 Prostate Neoplasms 21592394 "Among these miR-22, miR-29ab, miR-134, miR-1207-5p and miR-371-5p are up regulated, while miR-17 and miR-20a, members of the miR-17/92 cluster are down regulated." -tissue_expression_down hsa-mir-18 Prostate Neoplasms 21592394 "Among these miR-22, miR-29ab, miR-134, miR-1207-5p and miR-371-5p are up regulated, while miR-17 and miR-20a, members of the miR-17/92 cluster are down regulated." -tissue_expression_down hsa-mir-19a Prostate Neoplasms 21592394 "Among these miR-22, miR-29ab, miR-134, miR-1207-5p and miR-371-5p are up regulated, while miR-17 and miR-20a, members of the miR-17/92 cluster are down regulated." -tissue_expression_down hsa-mir-19b-1 Prostate Neoplasms 21592394 "Among these miR-22, miR-29ab, miR-134, miR-1207-5p and miR-371-5p are up regulated, while miR-17 and miR-20a, members of the miR-17/92 cluster are down regulated." -tissue_expression_down hsa-mir-20a Prostate Neoplasms 21592394 "Among these miR-22, miR-29ab, miR-134, miR-1207-5p and miR-371-5p are up regulated, while miR-17 and miR-20a, members of the miR-17/92 cluster are down regulated." -tissue_expression_down hsa-mir-92-1 Prostate Neoplasms 21592394 "Among these miR-22, miR-29ab, miR-134, miR-1207-5p and miR-371-5p are up regulated, while miR-17 and miR-20a, members of the miR-17/92 cluster are down regulated." -tissue_expression_down hsa-mir-21 Prostate Neoplasms 21594291 "In addition, anti-invasive microRNAs such as miR-335, miR-205, miR-200, and miR-126, were up-regulated, whereas pro-invasive microRNA such as miR-21 and miR-373, were down-regulated." -tissue_expression_down hsa-mir-373 Prostate Neoplasms 21594291 "In addition, anti-invasive microRNAs such as miR-335, miR-205, miR-200, and miR-126, were up-regulated, whereas pro-invasive microRNA such as miR-21 and miR-373, were down-regulated." -tissue_expression_down hsa-mir-205 "Carcinoma, Lung, Non-Small-Cell" 21622546 "Eighteen cases were classified as AD and 13 as SCC by light microscopy and immunocytochemistry. miRNA expression profiles demonstrated considerable, statistically significant differences between AD and SCC, showing an upregulation of hsa-let-7a, hsa-let-7b, hsa-let-7c,hsa-let-7f, hsa-let-7g, hsa-let-7i, and hsa-miR-98 and a downregulation of hsa-miR-205 in AD specimens" -tissue_expression_down hsa-mir-15a "Carcinoma, Hepatocellular" 21629246 Hepatitis B virus X protein downregulates expression of the miR-16 family in malignant hepatocytes in vitro. -tissue_expression_down hsa-mir-16-1 "Carcinoma, Hepatocellular" 21629246 Hepatitis B virus X protein downregulates expression of the miR-16 family in malignant hepatocytes in vitro. -tissue_expression_down hsa-mir-16-2 "Carcinoma, Hepatocellular" 21629246 Hepatitis B virus X protein downregulates expression of the miR-16 family in malignant hepatocytes in vitro. -tissue_expression_down hsa-mir-30a "Carcinoma, Lung, Non-Small-Cell" 21633953 MicroRNA-30a inhibits epithelial-to-mesenchymal transition by targeting Snai1 and is downregulated in non-small cell lung cancer. -tissue_expression_down hsa-mir-101-1 Head And Neck Neoplasms 21637912 hsa-mir-101 was downregulated compared with normal tissue. -tissue_expression_down hsa-mir-101-2 Head And Neck Neoplasms 21637912 hsa-mir-101 was downregulated compared with normal tissue. -tissue_expression_down hsa-mir-141 Head And Neck Neoplasms 21637912 hsa-mir-141 was downregulated compared with normal tissue. -tissue_expression_down hsa-mir-95 Head And Neck Neoplasms 21637912 hsa-mir-95 was downregulated compared with normal tissue. -tissue_expression_down hsa-mir-199a-1 Osteosarcoma 21666078 MicroRNA-199a-3p Is Downregulated in Human Osteosarcoma and Regulates Cell Proliferation and Migration. -tissue_expression_down hsa-mir-199a-2 Osteosarcoma 21666078 MicroRNA-199a-3p Is Downregulated in Human Osteosarcoma and Regulates Cell Proliferation and Migration. -tissue_expression_down hsa-mir-451a Breast Neoplasms 21666713 Tamoxifen downregulation of miR-451 increases 14-3-3 and promotes breast cancer cell survival and endocrine resistance. -tissue_expression_down hsa-mir-370 Gastric Neoplasms 21666718 Overexpression of miR-370 and downregulation of its novel target TGFbeta-RII contribute to the progression of gastric carcinoma. -tissue_expression_down hsa-mir-125a "Carcinoma, Rectal" 21671476 "One of the most up-regulated miRNAs, miRNA-106a, was consistently reported to be differentially expressed in six studies and the five most down-regulated miRNAs, miR-30a-3p, miR-139, miR-145, miR-125a and miR-133a, were consistently reported to be differentially expressed in four studies." -tissue_expression_down hsa-mir-133a "Carcinoma, Rectal" 21671476 "One of the most up-regulated miRNAs, miRNA-106a, was consistently reported to be differentially expressed in six studies and the five most down-regulated miRNAs, miR-30a-3p, miR-139, miR-145, miR-125a and miR-133a, were consistently reported to be differentially expressed in four studies." -tissue_expression_down hsa-mir-139 "Carcinoma, Rectal" 21671476 "One of the most up-regulated miRNAs, miRNA-106a, was consistently reported to be differentially expressed in six studies and the five most down-regulated miRNAs, miR-30a-3p, miR-139, miR-145, miR-125a and miR-133a, were consistently reported to be differentially expressed in four studies." -tissue_expression_down hsa-mir-145 "Carcinoma, Rectal" 21671476 "One of the most up-regulated miRNAs, miRNA-106a, was consistently reported to be differentially expressed in six studies and the five most down-regulated miRNAs, miR-30a-3p, miR-139, miR-145, miR-125a and miR-133a, were consistently reported to be differentially expressed in four studies." -tissue_expression_down hsa-mir-30a "Carcinoma, Rectal" 21671476 "One of the most up-regulated miRNAs, miRNA-106a, was consistently reported to be differentially expressed in six studies and the five most down-regulated miRNAs, miR-30a-3p, miR-139, miR-145, miR-125a and miR-133a, were consistently reported to be differentially expressed in four studies." -tissue_expression_down hsa-mir-128-1 Alzheimer Disease 21686130 miR-128a/b levels were significantly reduced in the temporal cortex and miR-128b in the frontal cortex in AD. -tissue_expression_down hsa-mir-128-2 Alzheimer Disease 21686130 miR-128a/b levels were significantly reduced in the temporal cortex and miR-128b in the frontal cortex in AD. -tissue_expression_down hsa-mir-211 Melanoma 21687938 Downregulation of microRNA-211 is involved in expression of preferentially expressed antigen of melanoma in melanoma cells. -tissue_expression_down hsa-mir-296 Heart Failure 21690488 "The absolute expression levels of hcmv-miR-UL112, miR-296-5p, and let-7e were further determined in 127 patients and 67 control subjects (fold changes are 2.5, 0.5, and 1.7 respectively; all P<0.0001)." -tissue_expression_down hsa-mir-106a Prostate Neoplasms 21714127 The down-regulated miRs included miR-17-92 and miR-106ab clusters with well recognized oncogenic properties while the up-regulated miRs included several tumor suppressors -tissue_expression_down hsa-mir-106b Prostate Neoplasms 21714127 The down-regulated miRs included miR-17-92 and miR-106ab clusters with well recognized oncogenic properties while the up-regulated miRs included several tumor suppressors -tissue_expression_down hsa-mir-17 Prostate Neoplasms 21714127 The down-regulated miRs included miR-17-92 and miR-106ab clusters with well recognized oncogenic properties while the up-regulated miRs included several tumor suppressors -tissue_expression_down hsa-mir-18 Prostate Neoplasms 21714127 The down-regulated miRs included miR-17-92 and miR-106ab clusters with well recognized oncogenic properties while the up-regulated miRs included several tumor suppressors -tissue_expression_down hsa-mir-19a Prostate Neoplasms 21714127 The down-regulated miRs included miR-17-92 and miR-106ab clusters with well recognized oncogenic properties while the up-regulated miRs included several tumor suppressors -tissue_expression_down hsa-mir-19b-1 Prostate Neoplasms 21714127 The down-regulated miRs included miR-17-92 and miR-106ab clusters with well recognized oncogenic properties while the up-regulated miRs included several tumor suppressors -tissue_expression_down hsa-mir-20a Prostate Neoplasms 21714127 The down-regulated miRs included miR-17-92 and miR-106ab clusters with well recognized oncogenic properties while the up-regulated miRs included several tumor suppressors -tissue_expression_down hsa-mir-92-1 Prostate Neoplasms 21714127 The down-regulated miRs included miR-17-92 and miR-106ab clusters with well recognized oncogenic properties while the up-regulated miRs included several tumor suppressors -tissue_expression_down hsa-mir-221 Kaposi Sarcoma 21715310 "In the present study, we show that Kaposi sarcoma-associated herpesvirus (KSHV), the etiological agent of KS, induces global miRNA changes in lymphatic endothelial cells (LECs). Specifically, the miR-221/miR-222 cluster is down-regulated, whereas miR-31 is up-regulated." -tissue_expression_down hsa-mir-222 Kaposi Sarcoma 21715310 "In the present study, we show that Kaposi sarcoma-associated herpesvirus (KSHV), the etiological agent of KS, induces global miRNA changes in lymphatic endothelial cells (LECs). Specifically, the miR-221/miR-222 cluster is down-regulated, whereas miR-31 is up-regulated." -tissue_expression_down hsa-mir-21 "Carcinoma, Lung, Small-Cell" 21731696 "The authors observed significantly lower miR-21, miR-29b, and miR-34a expression in SCLC cell lines than in NSCLC cell lines." -tissue_expression_down hsa-mir-29b-1 "Carcinoma, Lung, Small-Cell" 21731696 "The authors observed significantly lower miR-21, miR-29b, and miR-34a expression in SCLC cell lines than in NSCLC cell lines." -tissue_expression_down hsa-mir-29b-2 "Carcinoma, Lung, Small-Cell" 21731696 "The authors observed significantly lower miR-21, miR-29b, and miR-34a expression in SCLC cell lines than in NSCLC cell lines." -tissue_expression_down hsa-mir-34a "Carcinoma, Lung, Small-Cell" 21731696 "The authors observed significantly lower miR-21, miR-29b, and miR-34a expression in SCLC cell lines than in NSCLC cell lines." -tissue_expression_down hsa-mir-1 "Carcinoma, Renal Cell" 21745735 Our data indicate that up-regulation of the oncogenic TAGLN2 was due to down-regulation of tumour-suppressive miR-1 and miR-133a in human RCC. -tissue_expression_down hsa-mir-133a "Carcinoma, Renal Cell" 21745735 Our data indicate that up-regulation of the oncogenic TAGLN2 was due to down-regulation of tumour-suppressive miR-1 and miR-133a in human RCC. -tissue_expression_down hsa-mir-122 "Carcinoma, Hepatocellular" 21750653 The down-regulation of miR-122 activated the CDK4-PSMD10-UPR pathway to decrease tumor cell anticancer drug-mediated apoptosis. -tissue_expression_down hsa-mir-155 Melanoma 21763111 "Early steps in skin tumor formation in HPV8-CER mice were associated with an upregulation of the oncogenic miRNA-17-5p, -21 and -106a and a downregulation of the tumor-suppressive miRNA-155 and -206, which could be demonstrated by qPCR and in situ hybridization." -tissue_expression_down hsa-mir-206 Melanoma 21763111 "Early steps in skin tumor formation in HPV8-CER mice were associated with an upregulation of the oncogenic miRNA-17-5p, -21 and -106a and a downregulation of the tumor-suppressive miRNA-155 and -206, which could be demonstrated by qPCR and in situ hybridization." -tissue_expression_down hsa-mir-16-1 Lymphoma 21778999 Hypoxia-microRNA-16 downregulation induces VEGF expression in anaplastic lymphoma kinase (ALK)-positive anaplastic large-cell lymphomas. -tissue_expression_down hsa-mir-16-2 Lymphoma 21778999 Hypoxia-microRNA-16 downregulation induces VEGF expression in anaplastic lymphoma kinase (ALK)-positive anaplastic large-cell lymphomas. -tissue_expression_down hsa-mir-200c "Carcinoma, Renal Cell" 21784468 Underexpression -tissue_expression_down hsa-mir-218-1 "Carcinoma, Renal Cell" 21784468 Underexpression -tissue_expression_down hsa-mir-218-2 "Carcinoma, Renal Cell" 21784468 Underexpression -tissue_expression_down hsa-mir-335 "Carcinoma, Renal Cell" 21784468 Underexpression -tissue_expression_down hsa-mir-494 Cholangiocarcinoma 21809359 miRNA-494 downregulated in human cholangiocarcinoma controls cell cycle through multiple targets involved in the G1/S checkpoint. -tissue_expression_down hsa-mir-143 Colorectal Carcinoma 21826996 downregulated in colon cancer compared to normal colonic mucosa -tissue_expression_down hsa-mir-145 Colorectal Carcinoma 21826996 downregulated in colon cancer compared to normal colonic mucosa -tissue_expression_down hsa-mir-214 Breast Neoplasms 21828058 "Decreased MicroRNA-214 Levels In Breast Cancer Cells Coincides with Increased Cell Proliferation, Invasion, and Accumulation of the Polycomb Ezh2 Methyltransferase." -tissue_expression_down hsa-mir-146a "Carcinoma, Hepatocellular" 21829663 "miRNAs miR-26a, -29c, -146a and -190 were significantly down-regulated in a subset of HCC tissues with carboxyl-terminal HBx truncation compared to their matching non-tumor tissues." -tissue_expression_down hsa-mir-190a "Carcinoma, Hepatocellular" 21829663 "miRNAs miR-26a, -29c, -146a and -190 were significantly down-regulated in a subset of HCC tissues with carboxyl-terminal HBx truncation compared to their matching non-tumor tissues." -tissue_expression_down hsa-mir-26a-1 "Carcinoma, Hepatocellular" 21829663 "miRNAs miR-26a, -29c, -146a and -190 were significantly down-regulated in a subset of HCC tissues with carboxyl-terminal HBx truncation compared to their matching non-tumor tissues." -tissue_expression_down hsa-mir-26a-2 "Carcinoma, Hepatocellular" 21829663 "miRNAs miR-26a, -29c, -146a and -190 were significantly down-regulated in a subset of HCC tissues with carboxyl-terminal HBx truncation compared to their matching non-tumor tissues." -tissue_expression_down hsa-mir-29c "Carcinoma, Hepatocellular" 21829663 "miRNAs miR-26a, -29c, -146a and -190 were significantly down-regulated in a subset of HCC tissues with carboxyl-terminal HBx truncation compared to their matching non-tumor tissues." -tissue_expression_down hsa-mir-145 Melanoma 21836381 "MiR-145 was significantly down-regulated in canine malignant melanoma tissues. The ectopic expression of miR-145 showed a significant growth inhibition in both canine and human melanoma cells tested, and the effect was achieved partly by suppressing c-MYC in canine melanoma LMeC, and human melanoma A2058 and Mewo cells." -tissue_expression_down hsa-mir-195 "Carcinoma, Adrenocortical" 21859927 "Among others, miR-483-3p, miR-483-5p, miR-210, and miR-21 were found overexpressed,while miR-195, miR-497, and miR-1974 were underexpressed in ACC. " -tissue_expression_down hsa-mir-1974 "Carcinoma, Adrenocortical" 21859927 "Among others, miR-483-3p, miR-483-5p, miR-210, and miR-21 were found overexpressed,while miR-195, miR-497, and miR-1974 were underexpressed in ACC. " -tissue_expression_down hsa-mir-497 "Carcinoma, Adrenocortical" 21859927 "Among others, miR-483-3p, miR-483-5p, miR-210, and miR-21 were found overexpressed,while miR-195, miR-497, and miR-1974 were underexpressed in ACC. " -tissue_expression_down hsa-mir-224 Colorectal Carcinoma 21864507 Underexpression in methotrexate resistant human colon cancer cells. -tissue_expression_down hsa-let-7g Breast Neoplasms 21868760 "Treatment with estrogen or EGF specifically reduced the expression of mature let-7g through activation of p44/42 MAPK and subsequently stimulated expression of GAB2 and FN1, which in turn promoted tumor invasion. We thus identify let-7g as a unique member of the let-7 miRNA family which can serve as a prognostic biomarker in breast cancer and also propose a paradigm utilized by specific signaling molecules via let-7g to cooperatively promote breast cancer invasion and metastasis." -tissue_expression_down hsa-mir-451a "Carcinoma, Lung, Non-Small-Cell" 21875770 "This study showed that miRNA-451 expression decreased in non-small cell lung cancer (NSCLC) tissues and that its expression was negatively associated with lymph node metastasis, the stage of TNM classification and poor prognosis of NSCLC patients. Moreover, significantly different miRNA-451 expression levels were found between smoking and non-smoking patients. The overexpression of miRNA-451 inhibited cell cycle progression, cellular migration and the invasive ability of NSCLC cells.Increased miRNA-451 expression also promoted anoikis of NSCLC cells." -tissue_expression_down hsa-mir-221 "Carcinoma, Hepatocellular" 21876625 "downregulated in acute HBV infection, normally expressed in chronic HBV infection, and upregulated in HCC" -tissue_expression_down hsa-mir-221 Hepatitis B Virus Infection 21876625 "downregulated in acute HBV infection, normally expressed in chronic HBV infection, and upregulated in HCC" -tissue_expression_down hsa-mir-99a "Carcinoma, Hepatocellular" 21878637 "Lower miR-99a expression in HCC tissues significantly correlated with shorter survival of HCC patients, and miR-99a was identified to be an independent predictor for prognosis of HCC patients. Furthermore, restoration of miR-99a dramatically suppressed HCC cell growth in vitro by inducing G1 phase cell cycle arrest." -tissue_expression_down hsa-let-7c Prostate Neoplasms 21880514 significantly changed during the progression of cancer -tissue_expression_down hsa-mir-100 Prostate Neoplasms 21880514 significantly changed during the progression of cancer -tissue_expression_down hsa-mir-143 Prostate Neoplasms 21880514 significantly changed during the progression of cancer -tissue_expression_down hsa-mir-145 Prostate Neoplasms 21880514 significantly changed during the progression of cancer -tissue_expression_down hsa-mir-146a Prostate Neoplasms 21880514 significantly changed during the progression of cancer -tissue_expression_down hsa-mir-15a Prostate Neoplasms 21880514 significantly changed during the progression of cancer -tissue_expression_down hsa-mir-16-1 Prostate Neoplasms 21880514 significantly changed during the progression of cancer -tissue_expression_down hsa-mir-16-2 Prostate Neoplasms 21880514 significantly changed during the progression of cancer -tissue_expression_down hsa-mir-191 Prostate Neoplasms 21880514 significantly changed during the progression of cancer -tissue_expression_down hsa-mir-199a-1 Prostate Neoplasms 21880514 significantly changed during the progression of cancer -tissue_expression_down hsa-mir-199a-2 Prostate Neoplasms 21880514 significantly changed during the progression of cancer -tissue_expression_down hsa-mir-218-1 Prostate Neoplasms 21880514 significantly changed during the progression of cancer -tissue_expression_down hsa-mir-25 Prostate Neoplasms 21880514 significantly changed during the progression of cancer -tissue_expression_down hsa-mir-32 Prostate Neoplasms 21880514 significantly changed during the progression of cancer -tissue_expression_down hsa-mir-146a Diabetes Mellitus 21885871 "A total of 25 mmol/L glucose decreased miR-146a expression and increased FN expression compared with 5 mmol/L glucose in both cell types. miR-146a mimic transfection prevented such change, whereas miR-146a antagomir transfection in the cells in 5 mmol/L glucose caused FN upregulation. A luciferase assay confirmed miR-146a's binding to FN 3'-UTR. miR-146a was localized in the retinal endothelial cells and was decreased in diabetes. Intravitreal miR-146a mimic injection restored retinal miR-146a and increased FN in diabetes. Additional experiments showed that p300 regulates miR-146a." -tissue_expression_down hsa-mir-124-1 Glioblastoma 21912681 Significantly down-regulated in glioblastomas. -tissue_expression_down hsa-mir-124-2 Glioblastoma 21912681 Significantly down-regulated in glioblastomas. -tissue_expression_down hsa-mir-124-3 Glioblastoma 21912681 Significantly down-regulated in glioblastomas. -tissue_expression_down hsa-mir-128-1 Glioblastoma 21912681 Significantly down-regulated in glioblastomas. -tissue_expression_down hsa-mir-128-2 Glioblastoma 21912681 Significantly down-regulated in glioblastomas. -tissue_expression_down hsa-mir-139 Glioblastoma 21912681 Significantly down-regulated in glioblastomas. -tissue_expression_down hsa-mir-7-1 Glioblastoma 21912681 Significantly down-regulated in glioblastomas. -tissue_expression_down hsa-mir-7-2 Glioblastoma 21912681 Significantly down-regulated in glioblastomas. -tissue_expression_down hsa-mir-7-3 Glioblastoma 21912681 Significantly down-regulated in glioblastomas. -tissue_expression_down hsa-mir-873 Glioblastoma 21912681 Significantly down-regulated in glioblastomas. -tissue_expression_down hsa-mir-95 Glioblastoma 21912681 Significantly down-regulated in glioblastomas. -tissue_expression_down hsa-mir-146a Asthma 21917308 Measurement of the microRNA expression profile showed selective downregulation of miR-28-5p in CD8(+) T cells and reduction of miR-146a and miR-146b in both CD4(+) and CD8(+) T cells. -tissue_expression_down hsa-mir-146b Asthma 21917308 Measurement of the microRNA expression profile showed selective downregulation of miR-28-5p in CD8(+) T cells and reduction of miR-146a and miR-146b in both CD4(+) and CD8(+) T cells. -tissue_expression_down hsa-mir-28 Asthma 21917308 Measurement of the microRNA expression profile showed selective downregulation of miR-28-5p in CD8(+) T cells and reduction of miR-146a and miR-146b in both CD4(+) and CD8(+) T cells. -tissue_expression_down hsa-mir-101-1 "Lymphoma, T-Cell" 21921041 "Re-expression of downregulated miRNAs, such as mir-101, mir-26a, mir26b, mir-28-5 and mir-363, reduced the growth of NK cell line and modulated the expression of their predicted target genes." -tissue_expression_down hsa-mir-101-2 "Lymphoma, T-Cell" 21921041 "Re-expression of downregulated miRNAs, such as mir-101, mir-26a, mir26b, mir-28-5 and mir-363, reduced the growth of NK cell line and modulated the expression of their predicted target genes." -tissue_expression_down hsa-mir-26a-1 "Lymphoma, T-Cell" 21921041 "Re-expression of downregulated miRNAs, such as mir-101, mir-26a, mir26b, mir-28-5 and mir-363, reduced the growth of NK cell line and modulated the expression of their predicted target genes." -tissue_expression_down hsa-mir-26a-2 "Lymphoma, T-Cell" 21921041 "Re-expression of downregulated miRNAs, such as mir-101, mir-26a, mir26b, mir-28-5 and mir-363, reduced the growth of NK cell line and modulated the expression of their predicted target genes." -tissue_expression_down hsa-mir-26b "Lymphoma, T-Cell" 21921041 "Re-expression of downregulated miRNAs, such as mir-101, mir-26a, mir26b, mir-28-5 and mir-363, reduced the growth of NK cell line and modulated the expression of their predicted target genes." -tissue_expression_down hsa-mir-127 Colorectal Carcinoma 21922590 "The presence of the KRAS mutation was associated with up-regulation of miR-127-3p, miR-92a, and miR-486-3p and down-regulation of miR-378." -tissue_expression_down hsa-mir-486 Colorectal Carcinoma 21922590 "The presence of the KRAS mutation was associated with up-regulation of miR-127-3p, miR-92a, and miR-486-3p and down-regulation of miR-378." -tissue_expression_down hsa-mir-92a-1 Colorectal Carcinoma 21922590 "The presence of the KRAS mutation was associated with up-regulation of miR-127-3p, miR-92a, and miR-486-3p and down-regulation of miR-378." -tissue_expression_down hsa-mir-92a-2 Colorectal Carcinoma 21922590 "The presence of the KRAS mutation was associated with up-regulation of miR-127-3p, miR-92a, and miR-486-3p and down-regulation of miR-378." -tissue_expression_down hsa-mir-106a Medulloblastoma 21931624 hsa-mir-106a* was significantly down-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_down hsa-mir-10a Medulloblastoma 21931624 hsa-mir-10a was significantly down-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_down hsa-mir-219 Medulloblastoma 21931624 hsa-mir-219-5p was significantly down-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_down hsa-mir-219-1 Medulloblastoma 21931624 hsa-mir-219-1-3p was significantly down-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_down hsa-mir-302b Medulloblastoma 21931624 hsa-mir-302b* was significantly down-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_down hsa-mir-302d Medulloblastoma 21931624 hsa-mir-302d* was significantly down-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_down hsa-mir-373 Medulloblastoma 21931624 hsa-mir-373 was significantly down-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_down hsa-mir-483 Medulloblastoma 21931624 hsa-mir-483-5p was significantly down-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_down hsa-mir-504 Medulloblastoma 21931624 hsa-mir-504 was significantly down-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_down hsa-mir-92b Medulloblastoma 21931624 hsa-mir-92b* was significantly down-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_down hsa-mir-935 Medulloblastoma 21931624 hsa-mir-935 was significantly down-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_down hsa-mir-122 Asthenozoospermia 21933900 miR-122 was markedly decreased in azoospermia but increased in asthenozoospermia. -tissue_expression_down hsa-mir-146b Asthenozoospermia 21933900 miR-146b was markedly decreased in azoospermia but increased in asthenozoospermia. -tissue_expression_down hsa-mir-181a-2 Asthenozoospermia 21933900 miR-181a was markedly decreased in azoospermia but increased in asthenozoospermia. -tissue_expression_down hsa-mir-34c Asthenozoospermia 21933900 miR-34c-5p was markedly decreased in azoospermia but increased in asthenozoospermia. -tissue_expression_down hsa-mir-374b Asthenozoospermia 21933900 miR-374b was markedly decreased in azoospermia but increased in asthenozoospermia. -tissue_expression_down hsa-mir-509-1 Asthenozoospermia 21933900 miR-509-5p was markedly decreased in azoospermia but increased in asthenozoospermia. -tissue_expression_down hsa-mir-509-2 Asthenozoospermia 21933900 miR-509-5p was markedly decreased in azoospermia but increased in asthenozoospermia. -tissue_expression_down hsa-mir-509-3 Asthenozoospermia 21933900 miR-509-5p was markedly decreased in azoospermia but increased in asthenozoospermia. -tissue_expression_down hsa-mir-513a-1 Asthenozoospermia 21933900 miR-513a-5p was markedly decreased in azoospermia but increased in asthenozoospermia. -tissue_expression_down hsa-mir-513a-2 Asthenozoospermia 21933900 miR-513a-5p was markedly decreased in azoospermia but increased in asthenozoospermia. -tissue_expression_down hsa-let-7c Ovarian Neoplasms 21939554 The miRNA was downregulated in cis-platin resistant (A2780/CP70) vs. cis-platin sensitive (A2780) ovarian cancer cell lines. -tissue_expression_down hsa-mir-20b Ovarian Neoplasms 21939554 The miRNA was downregulated in cis-platin resistant (A2780/CP70) vs. cis-platin sensitive (A2780) ovarian cancer cell lines. -tissue_expression_down hsa-mir-542 Ovarian Neoplasms 21939554 The miRNA hsa-miR-542-3p was downregulated in cis-platin resistant (A2780/CP70) vs. cis-platin sensitive (A2780) ovarian cancer cell lines. -tissue_expression_down hsa-mir-625 Ovarian Neoplasms 21939554 The miRNA was downregulated in cis-platin resistant (A2780/CP70) vs. cis-platin sensitive (A2780) ovarian cancer cell lines. -tissue_expression_down hsa-mir-125b-1 Lichen Planus 21943223 "Increased expression of miR-21 and miR-203, decreased expression of miR-125, and down-regulation of p53 and deltaNp63 RNA were seen in OLP compared to normal oral mucosa. When comparing microRNA expression to levels of p53 and p63 RNA, a significant negative correlation was seen between deltaNp63 and miR-203 and between miR-21 and p53, respectively." -tissue_expression_down hsa-mir-125b-2 Lichen Planus 21943223 "Increased expression of miR-21 and miR-203, decreased expression of miR-125, and down-regulation of p53 and deltaNp63 RNA were seen in OLP compared to normal oral mucosa. When comparing microRNA expression to levels of p53 and p63 RNA, a significant negative correlation was seen between deltaNp63 and miR-203 and between miR-21 and p53, respectively." -tissue_expression_down hsa-mir-10b Breast Neoplasms 21953071 The miRNA was down-regulated during lobular neoplasia progression compared to normal epithelium. -tissue_expression_down hsa-mir-139 Breast Neoplasms 21953071 The miRNA was down-regulated during lobular neoplasia progression compared to normal epithelium. -tissue_expression_down hsa-mir-140 Breast Neoplasms 21953071 The miRNA was down-regulated during lobular neoplasia progression compared to normal epithelium. -tissue_expression_down hsa-mir-224 Breast Neoplasms 21953071 The miRNA was down-regulated during lobular neoplasia progression compared to normal epithelium. -tissue_expression_down hsa-mir-365a Breast Neoplasms 21953071 The miRNA was down-regulated during lobular neoplasia progression compared to normal epithelium. -tissue_expression_down hsa-mir-365b Breast Neoplasms 21953071 The miRNA was down-regulated during lobular neoplasia progression compared to normal epithelium. -tissue_expression_down hsa-mir-450a-1 Breast Neoplasms 21953071 The miRNA was down-regulated during lobular neoplasia progression compared to normal epithelium. -tissue_expression_down hsa-mir-450a-2 Breast Neoplasms 21953071 The miRNA was down-regulated during lobular neoplasia progression compared to normal epithelium. -tissue_expression_down hsa-mir-450b Breast Neoplasms 21953071 The miRNA was down-regulated during lobular neoplasia progression compared to normal epithelium. -tissue_expression_down hsa-mir-100 Pancreatic Neoplasms 21953293 Highly down-regulated in PDAC compared with normal ductal -tissue_expression_down hsa-mir-145 Pancreatic Neoplasms 21953293 Highly down-regulated in PDAC compared with normal ductal -tissue_expression_down hsa-mir-148a Pancreatic Neoplasms 21953293 Highly down-regulated in PDAC compared with normal ductal -tissue_expression_down hsa-mir-199b Pancreatic Neoplasms 21953293 miR-199b-5p: Highly down-regulated in PDAC compared with normal ductal -tissue_expression_down hsa-mir-451a Pancreatic Neoplasms 21953293 Highly down-regulated in PDAC compared with normal ductal -tissue_expression_down hsa-mir-101-1 Lymphoma 21960592 "The down-regulation of miR-16, miR-26a, miR-101, miR-29c and miR138 in the t(14;18)-negative FL( follicular lymphoma ) subset was associated with profound mRNA expression changes of potential target genes involving cell cycle control, apoptosis and B-cell differentiation. miR-16 target CHEK1 showed increased expression on the protein level in t(14;18)-negative FL, while TCL1A expression was reduced, in line with a partial loss of the germinal center B-cell phenotype in this FL subset." -tissue_expression_down hsa-mir-101-2 Lymphoma 21960592 "The down-regulation of miR-16, miR-26a, miR-101, miR-29c and miR138 in the t(14;18)-negative FL( follicular lymphoma ) subset was associated with profound mRNA expression changes of potential target genes involving cell cycle control, apoptosis and B-cell differentiation. miR-16 target CHEK1 showed increased expression on the protein level in t(14;18)-negative FL, while TCL1A expression was reduced, in line with a partial loss of the germinal center B-cell phenotype in this FL subset." -tissue_expression_down hsa-mir-138-1 Lymphoma 21960592 "The down-regulation of miR-16, miR-26a, miR-101, miR-29c and miR138 in the t(14;18)-negative FL( follicular lymphoma ) subset was associated with profound mRNA expression changes of potential target genes involving cell cycle control, apoptosis and B-cell differentiation. miR-16 target CHEK1 showed increased expression on the protein level in t(14;18)-negative FL, while TCL1A expression was reduced, in line with a partial loss of the germinal center B-cell phenotype in this FL subset." -tissue_expression_down hsa-mir-138-2 Lymphoma 21960592 "The down-regulation of miR-16, miR-26a, miR-101, miR-29c and miR138 in the t(14;18)-negative FL( follicular lymphoma ) subset was associated with profound mRNA expression changes of potential target genes involving cell cycle control, apoptosis and B-cell differentiation. miR-16 target CHEK1 showed increased expression on the protein level in t(14;18)-negative FL, while TCL1A expression was reduced, in line with a partial loss of the germinal center B-cell phenotype in this FL subset." -tissue_expression_down hsa-mir-16-1 Lymphoma 21960592 "The down-regulation of miR-16, miR-26a, miR-101, miR-29c and miR138 in the t(14;18)-negative FL( follicular lymphoma ) subset was associated with profound mRNA expression changes of potential target genes involving cell cycle control, apoptosis and B-cell differentiation. miR-16 target CHEK1 showed increased expression on the protein level in t(14;18)-negative FL, while TCL1A expression was reduced, in line with a partial loss of the germinal center B-cell phenotype in this FL subset." -tissue_expression_down hsa-mir-16-2 Lymphoma 21960592 "The down-regulation of miR-16, miR-26a, miR-101, miR-29c and miR138 in the t(14;18)-negative FL( follicular lymphoma ) subset was associated with profound mRNA expression changes of potential target genes involving cell cycle control, apoptosis and B-cell differentiation. miR-16 target CHEK1 showed increased expression on the protein level in t(14;18)-negative FL, while TCL1A expression was reduced, in line with a partial loss of the germinal center B-cell phenotype in this FL subset." -tissue_expression_down hsa-mir-29c Lymphoma 21960592 "The down-regulation of miR-16, miR-26a, miR-101, miR-29c and miR138 in the t(14;18)-negative FL( follicular lymphoma ) subset was associated with profound mRNA expression changes of potential target genes involving cell cycle control, apoptosis and B-cell differentiation. miR-16 target CHEK1 showed increased expression on the protein level in t(14;18)-negative FL, while TCL1A expression was reduced, in line with a partial loss of the germinal center B-cell phenotype in this FL subset." -tissue_expression_down hsa-let-7a-1 Mycosis Fungoides 21966986 "MiR-155 was only found to be slightly overexpressed in MF compared to healthy controls. Furthermore, metastatic MF demonstrated lower concentrations of let-7a, let-7d and let-7f when compared to MF limited to the skin." -tissue_expression_down hsa-let-7a-2 Mycosis Fungoides 21966986 "MiR-155 was only found to be slightly overexpressed in MF compared to healthy controls. Furthermore, metastatic MF demonstrated lower concentrations of let-7a, let-7d and let-7f when compared to MF limited to the skin." -tissue_expression_down hsa-let-7a-3 Mycosis Fungoides 21966986 "MiR-155 was only found to be slightly overexpressed in MF compared to healthy controls. Furthermore, metastatic MF demonstrated lower concentrations of let-7a, let-7d and let-7f when compared to MF limited to the skin." -tissue_expression_down hsa-let-7d Mycosis Fungoides 21966986 "MiR-155 was only found to be slightly overexpressed in MF compared to healthy controls. Furthermore, metastatic MF demonstrated lower concentrations of let-7a, let-7d and let-7f when compared to MF limited to the skin." -tissue_expression_down hsa-let-7f-1 Mycosis Fungoides 21966986 "MiR-155 was only found to be slightly overexpressed in MF compared to healthy controls. Furthermore, metastatic MF demonstrated lower concentrations of let-7a, let-7d and let-7f when compared to MF limited to the skin." -tissue_expression_down hsa-let-7f-2 Mycosis Fungoides 21966986 "MiR-155 was only found to be slightly overexpressed in MF compared to healthy controls. Furthermore, metastatic MF demonstrated lower concentrations of let-7a, let-7d and let-7f when compared to MF limited to the skin." -tissue_expression_down hsa-mir-21 Ovarian Neoplasms 21968270 miR-21 down-regulation promotes apoptosis and inhibits invasion and migration abilities of OVCAR3 (ovarian papillary adenocarcinoma cell lines) cells. -tissue_expression_down hsa-mir-138-1 "Squamous Cell Carcinoma, Head and Neck" 21969367 "In this study, the authors first confirm the microRNA-138-mediated down-regulation of FOSL1 in squamous cell carcinoma (SCC) cell lines." -tissue_expression_down hsa-mir-138-2 "Squamous Cell Carcinoma, Head and Neck" 21969367 "In this study, the authors first confirm the microRNA-138-mediated down-regulation of FOSL1 in squamous cell carcinoma (SCC) cell lines." -tissue_expression_down hsa-mir-410 Neuroblastoma 21970883 "Two, miR-487b and miR-410, were significantly downregulated in the high-risk group. Multivariable analyses showed miR-487b expression as associated with overall survival and disease-free survival in the whole cohort, independently of clinical covariates. Moreover, miR-487b and miR-410 expression was significantly associated with disease-free survival of the non-MYCN-amplified favourable neuroblastoma: localised (stage 1, 2 and 3) and stage 4 of infant <18 months.Conclusion:Expression of miR-487b and miR-410 shows predictive value beyond the classical high-/low-risk stratification and is a biomarker of relapse in favourable neuroblastoma." -tissue_expression_down hsa-mir-487b Neuroblastoma 21970883 "Two, miR-487b and miR-410, were significantly downregulated in the high-risk group. Multivariable analyses showed miR-487b expression as associated with overall survival and disease-free survival in the whole cohort, independently of clinical covariates. Moreover, miR-487b and miR-410 expression was significantly associated with disease-free survival of the non-MYCN-amplified favourable neuroblastoma: localised (stage 1, 2 and 3) and stage 4 of infant <18 months.Conclusion:Expression of miR-487b and miR-410 shows predictive value beyond the classical high-/low-risk stratification and is a biomarker of relapse in favourable neuroblastoma." -tissue_expression_down hsa-mir-107 Astrocytoma 21978395 "miR-107, miR-124, miR-138, and miR-149 were downregulated significantly in grade I-IV astrocytomas, and overexpression of miR-124 and miR-149 inhibited glioblastoma cell proliferation and migration." -tissue_expression_down hsa-mir-124-1 Astrocytoma 21978395 "miR-107, miR-124, miR-138, and miR-149 were downregulated significantly in grade I-IV astrocytomas, and overexpression of miR-124 and miR-149 inhibited glioblastoma cell proliferation and migration." -tissue_expression_down hsa-mir-124-2 Astrocytoma 21978395 "miR-107, miR-124, miR-138, and miR-149 were downregulated significantly in grade I-IV astrocytomas, and overexpression of miR-124 and miR-149 inhibited glioblastoma cell proliferation and migration." -tissue_expression_down hsa-mir-124-3 Astrocytoma 21978395 "miR-107, miR-124, miR-138, and miR-149 were downregulated significantly in grade I-IV astrocytomas, and overexpression of miR-124 and miR-149 inhibited glioblastoma cell proliferation and migration." -tissue_expression_down hsa-mir-138-1 Astrocytoma 21978395 "miR-107, miR-124, miR-138, and miR-149 were downregulated significantly in grade I-IV astrocytomas, and overexpression of miR-124 and miR-149 inhibited glioblastoma cell proliferation and migration." -tissue_expression_down hsa-mir-138-2 Astrocytoma 21978395 "miR-107, miR-124, miR-138, and miR-149 were downregulated significantly in grade I-IV astrocytomas, and overexpression of miR-124 and miR-149 inhibited glioblastoma cell proliferation and migration." -tissue_expression_down hsa-mir-149 Astrocytoma 21978395 "miR-107, miR-124, miR-138, and miR-149 were downregulated significantly in grade I-IV astrocytomas, and overexpression of miR-124 and miR-149 inhibited glioblastoma cell proliferation and migration." -tissue_expression_down hsa-mir-1290 "Carcinoma, Hepatocellular" 21998738 hsa-mir-1290 was down-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract. -tissue_expression_down hsa-mir-187 "Carcinoma, Hepatocellular" 21998738 hsa-mir-187* was down-regulated in HepG2 cells after 5 hours of culture with cocoa proanthocyanidin extract. -tissue_expression_down hsa-mir-2110 "Carcinoma, Hepatocellular" 21998738 hsa-mir-2110 was down-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract. -tissue_expression_down hsa-mir-30b "Carcinoma, Hepatocellular" 21998738 hsa-mir-30b* was down-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract. -tissue_expression_down hsa-mir-320c-1 "Carcinoma, Hepatocellular" 21998738 hsa-mir-320c was down-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract. -tissue_expression_down hsa-mir-320c-2 "Carcinoma, Hepatocellular" 21998738 hsa-mir-320c was down-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract. -tissue_expression_down hsa-mir-323b "Carcinoma, Hepatocellular" 21998738 hsa-mir-453 (note: this miRNA was replaced by hsa-mir-323b) was down-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract. -tissue_expression_down hsa-mir-483 "Carcinoma, Hepatocellular" 21998738 hsa-mir-483-5p was down-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract. -tissue_expression_down hsa-mir-520e "Carcinoma, Hepatocellular" 21998738 hsa-mir-520e was down-regulated in HepG2 cells after 5 hours of culture with epigallocatechin gallate. -tissue_expression_down hsa-mir-608 "Carcinoma, Hepatocellular" 21998738 hsa-mir-608 was down-regulated in HepG2 cells after 5 hours of culture with epigallocatechin gallate. -tissue_expression_down hsa-mir-629 "Carcinoma, Hepatocellular" 21998738 hsa-mir-629 was down-regulated in HepG2 cells after 5 hours of culture with epigallocatechin gallate. -tissue_expression_down hsa-mir-765 "Carcinoma, Hepatocellular" 21998738 hsa-mir-765 was down-regulated in HepG2 cells after 5 hours of culture with cocoa proanthocyanidin extract. -tissue_expression_down hsa-mir-1-1 "Aortic Aneurysm, Thoracic" 22010139 "miRs -1, -21, -29a, -133a, and -486 showed decreased expression in Thoracic Aortic Aneurysm compared to normal aortic specimens.A significant relationship between miR expression levels (miRs -1, -21, -29a, and -133a) and aortic diameter was identified;" -tissue_expression_down hsa-mir-1-2 "Aortic Aneurysm, Thoracic" 22010139 "miRs -1, -21, -29a, -133a, and -486 showed decreased expression in Thoracic Aortic Aneurysm compared to normal aortic specimens.A significant relationship between miR expression levels (miRs -1, -21, -29a, and -133a) and aortic diameter was identified;" -tissue_expression_down hsa-mir-133a-1 "Aortic Aneurysm, Thoracic" 22010139 "miRs -1, -21, -29a, -133a, and -486 showed decreased expression in Thoracic Aortic Aneurysm compared to normal aortic specimens.A significant relationship between miR expression levels (miRs -1, -21, -29a, and -133a) and aortic diameter was identified;" -tissue_expression_down hsa-mir-133a-2 "Aortic Aneurysm, Thoracic" 22010139 "miRs -1, -21, -29a, -133a, and -486 showed decreased expression in Thoracic Aortic Aneurysm compared to normal aortic specimens.A significant relationship between miR expression levels (miRs -1, -21, -29a, and -133a) and aortic diameter was identified;" -tissue_expression_down hsa-mir-21 "Aortic Aneurysm, Thoracic" 22010139 "miRs -1, -21, -29a, -133a, and -486 showed decreased expression in Thoracic Aortic Aneurysm compared to normal aortic specimens.A significant relationship between miR expression levels (miRs -1, -21, -29a, and -133a) and aortic diameter was identified;" -tissue_expression_down hsa-mir-29a "Aortic Aneurysm, Thoracic" 22010139 "miRs -1, -21, -29a, -133a, and -486 showed decreased expression in Thoracic Aortic Aneurysm compared to normal aortic specimens.A significant relationship between miR expression levels (miRs -1, -21, -29a, and -133a) and aortic diameter was identified;" -tissue_expression_down hsa-mir-26b Lichen Planus 22017396 Levels of COX-2 mRNA were significantly higher while levels of miR-26b were significantly lower in OLP lesions compared to controls. Increased expression of COX-2 and decreased expression of miR-26b in OLP suggests both to play a role in OLP. -tissue_expression_down hsa-mir-107 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-125a "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-125b-1 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-125b-2 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-133b "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-134 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-139 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-144 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-150 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-151a "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-181c "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-18a "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-195 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-197 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-200a "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-202 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-208a "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-208b "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-212 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-214 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-223 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-24-1 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-24-2 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-296 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-30d "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-320a "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-320b-1 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-320b-2 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-320c-1 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-320d-1 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-320e "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-324 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-326 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-330 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-345 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-346 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-361 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-365a "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-365b "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-370 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-373 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-378a "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-381 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-409 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-423 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-483 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-484 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-485 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-486 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-489 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-490 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-492 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-498 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-500a "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-500b "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-503 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-518b "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-520d "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-526a-1 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-526a-2 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-526b "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-527 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-542 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-92a-1 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-92a-2 "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-92b "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-99b "Carcinoma, Hepatocellular" 22027761 This miRNA was down-regulated in HepG2 cells treated with BJA32515. -tissue_expression_down hsa-mir-15a "Carcinoma, Hepatocellular" 22033921 The microRNA 15/16 cluster downregulates protein repair isoaspartyl methyltransferase in hepatoma cells. The authors conclude that PCMT is effectively regulated by the miR15a-16-1 cluster and is involved in apoptosis by preserving the structural stability and biological function of BclxL from deamidation. Control of PCMT expression by snRNAs may thus represent a late check point in apoptosis regulation. -tissue_expression_down hsa-mir-16-1 "Carcinoma, Hepatocellular" 22033921 The microRNA 15/16 cluster downregulates protein repair isoaspartyl methyltransferase in hepatoma cells. The authors conclude that PCMT is effectively regulated by the miR15a-16-1 cluster and is involved in apoptosis by preserving the structural stability and biological function of BclxL from deamidation. Control of PCMT expression by snRNAs may thus represent a late check point in apoptosis regulation. -tissue_expression_down hsa-let-7i "Cardiomyopathy, Dilated" 22041329 "Levels of let-7i, miR-126, and miR-155 were lower in the DCM group than in the controls, whereas levels of miR-21 and TLR4 (both mRNA and protein) were higher in the DCM group than in the control group. Levels of let-7i were negatively correlated with TLR4 protein levels in all subjects. After a mean follow-up period of 509 days, 6 DCM patients (5.8%) had died due to a cardiac cause and 15 (14.6%) had developed heart failure. When patients with DCM were divided into tertiles according to let-7i levels, log-rank analysis showed that the DCM subgroup with low let-7i levels was associated with poor clinical outcomes (P = .02)." -tissue_expression_down hsa-mir-126 "Cardiomyopathy, Dilated" 22041329 "Levels of let-7i, miR-126, and miR-155 were lower in the DCM group than in the controls, whereas levels of miR-21 and TLR4 (both mRNA and protein) were higher in the DCM group than in the control group. Levels of let-7i were negatively correlated with TLR4 protein levels in all subjects. After a mean follow-up period of 509 days, 6 DCM patients (5.8%) had died due to a cardiac cause and 15 (14.6%) had developed heart failure. When patients with DCM were divided into tertiles according to let-7i levels, log-rank analysis showed that the DCM subgroup with low let-7i levels was associated with poor clinical outcomes (P = .02)." -tissue_expression_down hsa-mir-155 "Cardiomyopathy, Dilated" 22041329 "Levels of let-7i, miR-126, and miR-155 were lower in the DCM group than in the controls, whereas levels of miR-21 and TLR4 (both mRNA and protein) were higher in the DCM group than in the control group. Levels of let-7i were negatively correlated with TLR4 protein levels in all subjects. After a mean follow-up period of 509 days, 6 DCM patients (5.8%) had died due to a cardiac cause and 15 (14.6%) had developed heart failure. When patients with DCM were divided into tertiles according to let-7i levels, log-rank analysis showed that the DCM subgroup with low let-7i levels was associated with poor clinical outcomes (P = .02)." -tissue_expression_down hsa-mir-150 Myocardial Infarction 22048267 "Comparing MI patients with VR and those without VR, we found miR-146a up-regulation, and miR-150 and miR-155 down-regulation in patients with VR. In conclusion, our study demonstrated an altered expression of miR-146a, miR-150, and miR-155 in MI compared to the normal hearts." -tissue_expression_down hsa-mir-155 Myocardial Infarction 22048267 "Comparing MI patients with VR and those without VR, we found miR-146a up-regulation, and miR-150 and miR-155 down-regulation in patients with VR. In conclusion, our study demonstrated an altered expression of miR-146a, miR-150, and miR-155 in MI compared to the normal hearts." -tissue_expression_down hsa-mir-383 Ependymoma 22053178 underexpression -tissue_expression_down hsa-mir-485 Ependymoma 22053178 miR-485-5p: underexpression -tissue_expression_down hsa-mir-365a Colon Neoplasms 22072615 "microRNA-365, down-regulated in colon cancer, inhibits cell cycle progression and promotes apoptosis of colon cancer cells by probably targeting Cyclin D1 and Bcl-2." -tissue_expression_down hsa-let-7a-1 Glioblastoma 22074483 "Significantly deregulated miRNAs were miR-3163 (fold change 2.0, p = 0.05), miR-539 (fold change 0.5, p = 0.001), miR-1305 (fold change 0.5, p = 0.05), miR-1260 (fold change 0.5, p = 0.03) and let-7a (fold change 0.3, p = 0.02) after temozolomide treatment." -tissue_expression_down hsa-let-7a-2 Glioblastoma 22074483 "Significantly deregulated miRNAs were miR-3163 (fold change 2.0, p = 0.05), miR-539 (fold change 0.5, p = 0.001), miR-1305 (fold change 0.5, p = 0.05), miR-1260 (fold change 0.5, p = 0.03) and let-7a (fold change 0.3, p = 0.02) after temozolomide treatment." -tissue_expression_down hsa-let-7a-3 Glioblastoma 22074483 "Significantly deregulated miRNAs were miR-3163 (fold change 2.0, p = 0.05), miR-539 (fold change 0.5, p = 0.001), miR-1305 (fold change 0.5, p = 0.05), miR-1260 (fold change 0.5, p = 0.03) and let-7a (fold change 0.3, p = 0.02) after temozolomide treatment." -tissue_expression_down hsa-mir-1260a Glioblastoma 22074483 "Significantly deregulated miRNAs were miR-3163 (fold change 2.0, p = 0.05), miR-539 (fold change 0.5, p = 0.001), miR-1305 (fold change 0.5, p = 0.05), miR-1260 (fold change 0.5, p = 0.03) and let-7a (fold change 0.3, p = 0.02) after temozolomide treatment." -tissue_expression_down hsa-mir-1305 Glioblastoma 22074483 "Significantly deregulated miRNAs were miR-3163 (fold change 2.0, p = 0.05), miR-539 (fold change 0.5, p = 0.001), miR-1305 (fold change 0.5, p = 0.05), miR-1260 (fold change 0.5, p = 0.03) and let-7a (fold change 0.3, p = 0.02) after temozolomide treatment." -tissue_expression_down hsa-mir-539 Glioblastoma 22074483 "Significantly deregulated miRNAs were miR-3163 (fold change 2.0, p = 0.05), miR-539 (fold change 0.5, p = 0.001), miR-1305 (fold change 0.5, p = 0.05), miR-1260 (fold change 0.5, p = 0.03) and let-7a (fold change 0.3, p = 0.02) after temozolomide treatment." -tissue_expression_down hsa-mir-27b Lichen Planus 22077423 "miR-27b was significantly down-regulated in OLP tissue, and miR-27b expression was even more suppressed in atrophic-erosive OLP than in reticular OLP. In addition, miR-27b was found to be expressed in the epithelial keratinocyte layer of both normal and OLP tissues." -tissue_expression_down hsa-mir-449a "Carcinoma, Lung, Non-Small-Cell" 22078727 "miR-449a/b was significantly down-regulated in lung cancer tissues compared with normal lung tissues, while HDAC1 was up-regulated in lung cancer tissues.Combined treatment with miR-449a and HDAC inhibitors (apicidin and TSA) in HCC95 cells showed a significant growth reduction compared to mono-treatment with HDAC inhibitors. Interestingly, combination treatment with TSA and miR-449a was had significant growth reduction than a combination with apicidin." -tissue_expression_down hsa-mir-449b "Carcinoma, Lung, Non-Small-Cell" 22078727 "miR-449a/b was significantly down-regulated in lung cancer tissues compared with normal lung tissues, while HDAC1 was up-regulated in lung cancer tissues.Combined treatment with miR-449a and HDAC inhibitors (apicidin and TSA) in HCC95 cells showed a significant growth reduction compared to mono-treatment with HDAC inhibitors. Interestingly, combination treatment with TSA and miR-449a was had significant growth reduction than a combination with apicidin." -tissue_expression_down hsa-mir-218-1 Glioma 22088371 "The expression level of miR-218 is an important reference indicator for the assessment of the grade of gliomas. An aberrant decrease of its expression may lead to an increase of the CDK6 expression and proliferative activity of giloma cells. Introducing exogenous miR-218 may effectively down-regulate the CDK6 expression, inhibit cell proliferation and induce apoptosis of malignant giloma cells." -tissue_expression_down hsa-mir-218-2 Glioma 22088371 "The expression level of miR-218 is an important reference indicator for the assessment of the grade of gliomas. An aberrant decrease of its expression may lead to an increase of the CDK6 expression and proliferative activity of giloma cells. Introducing exogenous miR-218 may effectively down-regulate the CDK6 expression, inhibit cell proliferation and induce apoptosis of malignant giloma cells." -tissue_expression_down hsa-mir-203 Barrett Esophagus 22094011 "We demonstrated unequivocal statistically significant upregulation of two microRNAs (miR-192, 196a) and downregulation of miR-203 and positive miR-196a correlation with progression from intestinal metaplasia to adenocarcinoma compared to normal individuals." -tissue_expression_down hsa-mir-200c Breast Neoplasms 22101791 "Down-regulation of microRNA-200c is associated with drug resistance in human breast cancer.Down-regulated miR-200c was observed in non-responders as compared to responders. In addition, miR-200c expression was observed to be down-regulated over 800-fold in human breast cancer cells resistant to doxorubicin MCF-7/ADR as compared to the parental MCF-7 cells. Up-regulation of miR-200c with transfection of miR-200c mimics in breast cancer cells could enhance the chemosensitivity to epirubicin and reduce expression of multidrug resistance 1 mRNA and P-glycoprotein. Moreover, our study demonstrated that restoration of miR-200c in MCF-7/ADR cells could increase intracellular doxorubicin accumulation determined by flow cytometry." -tissue_expression_down hsa-mir-34a Pancreatic Neoplasms 22114136 "In the initial cohort of 48 PDAC (pancreatic ductal adenocarcinoma) patients, high expression of miR-21 (Hazard ratio (HR): 3.22, 95% Confidence Interval (CI):1.21-8.58) and reduced expression of miR-34a (HR 0.15, 95%CI: 0.06-0.37) and miR-30d (HR:0.30, 95%CI:0.12-0.79) were associated with poor overall survival following resection independent of clinical covariates. In a further validation set of 24 patients miR-21 and miR-34a expression again significantly correlated with overall survival (P = 0.031 and P = 0.001)." -tissue_expression_down hsa-mir-206 Colorectal Carcinoma 22120473 "Increased expression of miR-21, mir-135a and miR-335 was associated with clinical progression of CRC (colorectal cancer), while miR-206 demonstrated an opposite trend. The levels of mir-21 did not associate with the expression of PTEN, an important tumour suppressor in CRC and one of many putative targets of miR-21, but interestingly was associated with stage of disease in the PTEN expressing tumours. Surprisingly, let7a, a KRAS-targeting miR, showed elevated expression in metastatic disease compared to normal mucosa or non-metastatic disease, and only in KRAS mutation positive tumors. Finally, a prognostic signature of miR 21,135a, 335, 206 and let-7a for detecting the presence of metastases had a specificity of 87% and sensitivity of 76% for the presence of metastases." -tissue_expression_down hsa-mir-221 Prostate Neoplasms 22127852 The altered expression of MiR-221/-222 (increased miR-221/-222 expression ) and MiR-23b/-27b (down-regulated ) is associated with the development of human castration resistant prostate cancer. -tissue_expression_down hsa-mir-222 Prostate Neoplasms 22127852 The altered expression of MiR-221/-222 (increased miR-221/-222 expression ) and MiR-23b/-27b (down-regulated ) is associated with the development of human castration resistant prostate cancer. -tissue_expression_down hsa-mir-23b Prostate Neoplasms 22127852 The altered expression of MiR-221/-222 (increased miR-221/-222 expression ) and MiR-23b/-27b (down-regulated ) is associated with the development of human castration resistant prostate cancer. -tissue_expression_down hsa-mir-27b Prostate Neoplasms 22127852 The altered expression of MiR-221/-222 (increased miR-221/-222 expression ) and MiR-23b/-27b (down-regulated ) is associated with the development of human castration resistant prostate cancer. -tissue_expression_down hsa-mir-107 Head And Neck Neoplasms 22158047 microRNA-107 functions as a candidate tumor-suppressor gene in head and neck squamous cell carcinoma by downregulation of protein kinase C -tissue_expression_down hsa-mir-720 Rectal Neoplasms 22172905 "Microarray analysis selected 14 miRNAs as being differentially expressed in TRG1 patients, and 13 were confirmed by qRT-PCR: 11 miRNAs (miR-1183, miR-483-5p, miR-622, miR-125a-3p, miR-1224-5p, miR-188-5p, miR-1471, miR-671-5p, miR-1909, miR-630, miR-765) were significantly upregulated in TRG1 patients, 2 (miR-1274b, miR-720) were downexpressed. MiR-622 and miR-630 had a 100% sensitivity and specificity in selecting TRG1 cases." -tissue_expression_down hsa-mir-122 "Carcinoma, Hepatocellular" 22174818 "Although miR-222, miR-223 or miR-21 were significantly up- or down-regulated between HCC patients and healthy controls, no significant difference was observed in the levels of these miRNAs between HBV patients without and with HCC. MiR-122 in serum was significantly higher in HCC patients than healthy controls (p<0.001). More importantly, it was found that the levels of miR-122 were significantly reduced in the post-operative serum samples when compared to the pre-operative samples. Although serum miR-122 was also elevated in HBV patients with HCC comparing with those without HCC, the difference was at the border line (p=0.043)." -tissue_expression_down hsa-mir-21 "Carcinoma, Hepatocellular" 22174818 "Although miR-222, miR-223 or miR-21 were significantly up- or down-regulated between HCC patients and healthy controls, no significant difference was observed in the levels of these miRNAs between HBV patients without and with HCC. MiR-122 in serum was significantly higher in HCC patients than healthy controls (p<0.001). More importantly, it was found that the levels of miR-122 were significantly reduced in the post-operative serum samples when compared to the pre-operative samples. Although serum miR-122 was also elevated in HBV patients with HCC comparing with those without HCC, the difference was at the border line (p=0.043)." -tissue_expression_down hsa-mir-222 "Carcinoma, Hepatocellular" 22174818 "Although miR-222, miR-223 or miR-21 were significantly up- or down-regulated between HCC patients and healthy controls, no significant difference was observed in the levels of these miRNAs between HBV patients without and with HCC. MiR-122 in serum was significantly higher in HCC patients than healthy controls (p<0.001). More importantly, it was found that the levels of miR-122 were significantly reduced in the post-operative serum samples when compared to the pre-operative samples. Although serum miR-122 was also elevated in HBV patients with HCC comparing with those without HCC, the difference was at the border line (p=0.043)." -tissue_expression_down hsa-mir-223 "Carcinoma, Hepatocellular" 22174818 "Although miR-222, miR-223 or miR-21 were significantly up- or down-regulated between HCC patients and healthy controls, no significant difference was observed in the levels of these miRNAs between HBV patients without and with HCC. MiR-122 in serum was significantly higher in HCC patients than healthy controls (p<0.001). More importantly, it was found that the levels of miR-122 were significantly reduced in the post-operative serum samples when compared to the pre-operative samples. Although serum miR-122 was also elevated in HBV patients with HCC comparing with those without HCC, the difference was at the border line (p=0.043)." -tissue_expression_down hsa-mir-1231 Colon Neoplasms 22180714 "Compared with expression in SW1116 cells, 35 miRNAs (including hsa-miR-192, hsa-miR-29b, hsa-miR-215, hsa-miR-194, hsa-miR-33a and hsa-miR-32) were upregulated more than 1.5-fold, and 11 miRNAs (including hsa-miR-93, hsa-miR-1231, hsa-miRPlus-F1080, hsa-miR-524-3p, hsa-miR-886-3p and hsa-miR-561) were downregulated in SW1116csc." -tissue_expression_down hsa-mir-524 Colon Neoplasms 22180714 "Compared with expression in SW1116 cells, 35 miRNAs (including hsa-miR-192, hsa-miR-29b, hsa-miR-215, hsa-miR-194, hsa-miR-33a and hsa-miR-32) were upregulated more than 1.5-fold, and 11 miRNAs (including hsa-miR-93, hsa-miR-1231, hsa-miRPlus-F1080, hsa-miR-524-3p, hsa-miR-886-3p and hsa-miR-561) were downregulated in SW1116csc." -tissue_expression_down hsa-mir-561 Colon Neoplasms 22180714 "Compared with expression in SW1116 cells, 35 miRNAs (including hsa-miR-192, hsa-miR-29b, hsa-miR-215, hsa-miR-194, hsa-miR-33a and hsa-miR-32) were upregulated more than 1.5-fold, and 11 miRNAs (including hsa-miR-93, hsa-miR-1231, hsa-miRPlus-F1080, hsa-miR-524-3p, hsa-miR-886-3p and hsa-miR-561) were downregulated in SW1116csc." -tissue_expression_down hsa-mir-886 Colon Neoplasms 22180714 "Compared with expression in SW1116 cells, 35 miRNAs (including hsa-miR-192, hsa-miR-29b, hsa-miR-215, hsa-miR-194, hsa-miR-33a and hsa-miR-32) were upregulated more than 1.5-fold, and 11 miRNAs (including hsa-miR-93, hsa-miR-1231, hsa-miRPlus-F1080, hsa-miR-524-3p, hsa-miR-886-3p and hsa-miR-561) were downregulated in SW1116csc." -tissue_expression_down hsa-mir-93 Colon Neoplasms 22180714 "Compared with expression in SW1116 cells, 35 miRNAs (including hsa-miR-192, hsa-miR-29b, hsa-miR-215, hsa-miR-194, hsa-miR-33a and hsa-miR-32) were upregulated more than 1.5-fold, and 11 miRNAs (including hsa-miR-93, hsa-miR-1231, hsa-miRPlus-F1080, hsa-miR-524-3p, hsa-miR-886-3p and hsa-miR-561) were downregulated in SW1116csc." -tissue_expression_down hsa-mir-143 "Allergic Rhinitis,Perennial" 22185732 down-regulated -tissue_expression_down hsa-mir-187 "Allergic Rhinitis,Perennial" 22185732 down-regulated -tissue_expression_down hsa-mir-224 "Allergic Rhinitis,Perennial" 22185732 down-regulated -tissue_expression_down hsa-mir-498 "Allergic Rhinitis,Perennial" 22185732 down-regulated -tissue_expression_down hsa-mir-767 "Allergic Rhinitis,Perennial" 22185732 miR-767-5p: down-regulated -tissue_expression_down hsa-mir-874 "Allergic Rhinitis,Perennial" 22185732 down-regulated -tissue_expression_down hsa-mir-143 Urinary Bladder Cancer 22194833 mir-21 expression increased with worsening clinical diagnosis but that mir-143 was not correlated with histology. These observations were in stark contrast to previous reports involving cervical cancer cell lines in which mir-143 was consistently down-regulated but mir-21 largely unaffected. -tissue_expression_down hsa-mir-192 Gastric Neoplasms 22205577 The down-regulation of miR-192 and -215 was demonstrated to be associated with increased tumor sizes and advanced Borrmann type tumors. -tissue_expression_down hsa-mir-150 Acquired Immunodeficiency Syndrome 22205749 "we used microarray expression analysis to identify miRNAs miR-27b, miR-29b, miR-150, and miR-223 as being significantly downregulated upon CD4(+) T cell activation" -tissue_expression_down hsa-mir-223 Acquired Immunodeficiency Syndrome 22205749 "we used microarray expression analysis to identify miRNAs miR-27b, miR-29b, miR-150, and miR-223 as being significantly downregulated upon CD4(+) T cell activation" -tissue_expression_down hsa-mir-27b Acquired Immunodeficiency Syndrome 22205749 "we used microarray expression analysis to identify miRNAs miR-27b, miR-29b, miR-150, and miR-223 as being significantly downregulated upon CD4(+) T cell activation" -tissue_expression_down hsa-mir-29b Acquired Immunodeficiency Syndrome 22205749 "we used microarray expression analysis to identify miRNAs miR-27b, miR-29b, miR-150, and miR-223 as being significantly downregulated upon CD4(+) T cell activation" -tissue_expression_down hsa-mir-200a Diabetic Nephropathy 22211842 "TGF-beta1 activates Smad3 to regulate microRNAs that mediate renal fibrosis. Of them, miR-21 and miR-192 are upregulated but miR-29 and miR-200 families are downregulated." -tissue_expression_down hsa-mir-200b Diabetic Nephropathy 22211842 "TGF-beta1 activates Smad3 to regulate microRNAs that mediate renal fibrosis. Of them, miR-21 and miR-192 are upregulated but miR-29 and miR-200 families are downregulated." -tissue_expression_down hsa-mir-200c Diabetic Nephropathy 22211842 "TGF-beta1 activates Smad3 to regulate microRNAs that mediate renal fibrosis. Of them, miR-21 and miR-192 are upregulated but miR-29 and miR-200 families are downregulated." -tissue_expression_down hsa-mir-29a Diabetic Nephropathy 22211842 "TGF-beta1 activates Smad3 to regulate microRNAs that mediate renal fibrosis. Of them, miR-21 and miR-192 are upregulated but miR-29 and miR-200 families are downregulated." -tissue_expression_down hsa-mir-29b-1 Diabetic Nephropathy 22211842 "TGF-beta1 activates Smad3 to regulate microRNAs that mediate renal fibrosis. Of them, miR-21 and miR-192 are upregulated but miR-29 and miR-200 families are downregulated." -tissue_expression_down hsa-mir-29b-2 Diabetic Nephropathy 22211842 "TGF-beta1 activates Smad3 to regulate microRNAs that mediate renal fibrosis. Of them, miR-21 and miR-192 are upregulated but miR-29 and miR-200 families are downregulated." -tissue_expression_down hsa-mir-29c Diabetic Nephropathy 22211842 "TGF-beta1 activates Smad3 to regulate microRNAs that mediate renal fibrosis. Of them, miR-21 and miR-192 are upregulated but miR-29 and miR-200 families are downregulated." -tissue_expression_down hsa-mir-145 "Carcinoma, Hepatocellular" 22213236 down-regulated in HCC tissues. -tissue_expression_down hsa-mir-146a "Carcinoma, Hepatocellular" 22213236 down-regulated in HCC tissues. -tissue_expression_down hsa-mir-200c "Carcinoma, Hepatocellular" 22213236 down-regulated in HCC tissues. -tissue_expression_down hsa-mir-223 "Carcinoma, Hepatocellular" 22213236 down-regulated in HCC tissues. -tissue_expression_down hsa-mir-146a Pancreatic Neoplasms 22213426 "We found over-expression of miR-21, miR-221, miR-27a, miR-27b, and miR-155, and down-regulation of miR-216a,miR-216b, miR-217, and miR-146a expression in tumors derived from KC and KCI mouse model" -tissue_expression_down hsa-mir-216a Pancreatic Neoplasms 22213426 "We found over-expression of miR-21, miR-221, miR-27a, miR-27b, and miR-155, and down-regulation of miR-216a,miR-216b, miR-217, and miR-146a expression in tumors derived from KC and KCI mouse model" -tissue_expression_down hsa-mir-216b Pancreatic Neoplasms 22213426 "We found over-expression of miR-21, miR-221, miR-27a, miR-27b, and miR-155, and down-regulation of miR-216a,miR-216b, miR-217, and miR-146a expression in tumors derived from KC and KCI mouse model" -tissue_expression_down hsa-mir-217 Pancreatic Neoplasms 22213426 "We found over-expression of miR-21, miR-221, miR-27a, miR-27b, and miR-155, and down-regulation of miR-216a,miR-216b, miR-217, and miR-146a expression in tumors derived from KC and KCI mouse model" -tissue_expression_down hsa-mir-200c Melanoma 22223089 "miR-200c, miR-205 and miR-211 are downregulated in melanoma and act as tumour suppressors." -tissue_expression_down hsa-mir-205 Melanoma 22223089 "miR-200c, miR-205 and miR-211 are downregulated in melanoma and act as tumour suppressors." -tissue_expression_down hsa-mir-211 Melanoma 22223089 "miR-200c, miR-205 and miR-211 are downregulated in melanoma and act as tumour suppressors." -tissue_expression_down hsa-mir-375 Head And Neck Neoplasms 22234174 Low-Level Expression of miR-375 Correlates with Poor Outcome and Metastasis While Altering the Invasive Properties of Head and Neck Squamous Cell Carcinomas. -tissue_expression_down hsa-mir-203 Melanoma 22235882 "A decreased expression of miR-203 was significantly associated with a shorter survival time. Also, miR-203 and -205 were markedly down-regulated in canine and human MM cell lines tested." -tissue_expression_down hsa-mir-205 Melanoma 22235882 "A decreased expression of miR-203 was significantly associated with a shorter survival time. Also, miR-203 and -205 were markedly down-regulated in canine and human MM cell lines tested." -tissue_expression_down hsa-let-7e Colorectal Carcinoma 22241525 "Six miRNAs were up-regulated from non-neoplastic tissue to dysplasia, but down-regulated from dysplasia to cancer (miR-122, miR-181a, miR-146b-5p, let-7e, miR-17, miR-143)" -tissue_expression_down hsa-mir-122 Colorectal Carcinoma 22241525 "Six miRNAs were up-regulated from non-neoplastic tissue to dysplasia, but down-regulated from dysplasia to cancer (miR-122, miR-181a, miR-146b-5p, let-7e, miR-17, miR-143)" -tissue_expression_down hsa-mir-143 Colorectal Carcinoma 22241525 "Six miRNAs were up-regulated from non-neoplastic tissue to dysplasia, but down-regulated from dysplasia to cancer (miR-122, miR-181a, miR-146b-5p, let-7e, miR-17, miR-143)" -tissue_expression_down hsa-mir-146b Colorectal Carcinoma 22241525 "Six miRNAs were up-regulated from non-neoplastic tissue to dysplasia, but down-regulated from dysplasia to cancer (miR-122, miR-181a, miR-146b-5p, let-7e, miR-17, miR-143)" -tissue_expression_down hsa-mir-17 Colorectal Carcinoma 22241525 "Six miRNAs were up-regulated from non-neoplastic tissue to dysplasia, but down-regulated from dysplasia to cancer (miR-122, miR-181a, miR-146b-5p, let-7e, miR-17, miR-143)" -tissue_expression_down hsa-mir-181a-2 Colorectal Carcinoma 22241525 "Six miRNAs were up-regulated from non-neoplastic tissue to dysplasia, but down-regulated from dysplasia to cancer (miR-122, miR-181a, miR-146b-5p, let-7e, miR-17, miR-143)" -tissue_expression_down hsa-mir-146b Neuroblastoma 22244746 under-expressed in mature neuron. -tissue_expression_down hsa-mir-152 Neuroblastoma 22244746 under-expressed in mature neuron. -tissue_expression_down hsa-mir-339 Neuroblastoma 22244746 miR-339-5p: under-expressed in mature neuron. -tissue_expression_down hsa-mir-370 Neuroblastoma 22244746 under-expressed in neuroblastoma. -tissue_expression_down hsa-mir-9-1 Neuroblastoma 22244746 under-expressed in neuroblastoma. -tissue_expression_down hsa-mir-9-2 Neuroblastoma 22244746 under-expressed in neuroblastoma. -tissue_expression_down hsa-mir-9-3 Neuroblastoma 22244746 under-expressed in neuroblastoma. -tissue_expression_down hsa-mir-34b Parkinson Disease 22245218 "miR-133b is deficient in the PD midbrain as well as in mouse models, and miR-34b/34c are decreased in several affected brain regions in PD and incidental Lewy body disease." -tissue_expression_down hsa-mir-34c Parkinson Disease 22245218 "miR-133b is deficient in the PD midbrain as well as in mouse models, and miR-34b/34c are decreased in several affected brain regions in PD and incidental Lewy body disease." -tissue_expression_down hsa-mir-100 Ovarian Neoplasms 22246341 "The level of miR-100 was significantly lower in EOC (epithelial ovarian cancer) tissues compared to adjacent normal tissues. Low miR-100 expression was found to be closely correlated with advanced FIGO stage, higher serum CA125 expression level and lymph node involvement." -tissue_expression_down hsa-mir-143 Colorectal Carcinoma 22273643 Down-regulation of fecal miR-143 and miR-145 are potential markers for colorectal cancer. -tissue_expression_down hsa-mir-145 Colorectal Carcinoma 22273643 Down-regulation of fecal miR-143 and miR-145 are potential markers for colorectal cancer. -tissue_expression_down hsa-let-7c "Carcinoma, Hepatocellular" 22289550 Levels of let-7c miRNA were significantly lower in HCC tissues than in corresponding normal adjacent tumour tissues and there was a correlation between the downregulation of let-7c and poor tissue differentiation in HCC. -tissue_expression_down hsa-mir-134 Lung Neoplasms 22306127 miR-27b and miR-134 levels were significantly lower in the tumors than normal tissue. -tissue_expression_down hsa-mir-27b Lung Neoplasms 22306127 miR-27b and miR-134 levels were significantly lower in the tumors than normal tissue. -tissue_expression_down hsa-mir-125a Lymphoma 22307176 significantly underexpressed in SMZL (splenic marginal zone lymphoma). -tissue_expression_down hsa-mir-126 Lymphoma 22307176 significantly underexpressed in SMZL (splenic marginal zone lymphoma). -tissue_expression_down hsa-mir-139 Lymphoma 22307176 significantly underexpressed in SMZL (splenic marginal zone lymphoma). -tissue_expression_down hsa-mir-146a Lymphoma 22307176 significantly overexpressed in SMZL (splenic marginal zone lymphoma). -tissue_expression_down hsa-mir-155 Lymphoma 22307176 significantly overexpressed in SMZL (splenic marginal zone lymphoma). -tissue_expression_down hsa-mir-21 Lymphoma 22307176 significantly overexpressed in SMZL (splenic marginal zone lymphoma). -tissue_expression_down hsa-mir-345 Lymphoma 22307176 significantly underexpressed in SMZL (splenic marginal zone lymphoma). -tissue_expression_down hsa-mir-122 "Carcinoma, Hepatocellular" 22312705 MiR-122 increases sensitivity of drug-resistant BEL-7402/5-FU cells to 5-fluorouracil via down-regulation of bcl-2 family proteins. -tissue_expression_down hsa-mir-1322 Esophageal Neoplasms 22315007 "miR-1322 could significantly down-regulate the ECRG2 with TCA3 allele (P<0.01), but it could not down-regulate the ECRG2 with TCA4 allele significantly (P>0.05). MicroRNA-1322 regulates ECRG2 allele specifically and acts as a potential biomarker in patients with esophageal squamous cell carcinoma." -tissue_expression_down hsa-mir-132 Schizophrenia 22315408 MicroRNA-132 downregulation in schizophrenia has implications for both neurodevelopment and adult brain function. -tissue_expression_down hsa-let-7d Breast Neoplasms 22315424 "let-7d, miR-210, and -221 were down-regulated in the in situ and up-regulated in the invasive transition, thus featuring an expression reversal along the cancer progression path." -tissue_expression_down hsa-mir-210 Breast Neoplasms 22315424 "let-7d, miR-210, and -221 were down-regulated in the in situ and up-regulated in the invasive transition, thus featuring an expression reversal along the cancer progression path." -tissue_expression_down hsa-mir-221 Breast Neoplasms 22315424 "let-7d, miR-210, and -221 were down-regulated in the in situ and up-regulated in the invasive transition, thus featuring an expression reversal along the cancer progression path." -tissue_expression_down hsa-mir-223 "Leukemia, Lymphocytic, Chronic, B-Cell" 22321781 The down-regulation of microRNA-223 was associated with disease aggressiveness in CLL. -tissue_expression_down hsa-mir-193a Lung Neoplasms 22325218 mir-33a was down-regulated by 92.8% and mir-193a-3p by 86.5% in epithelial-mesenchymal transition (EMT) on the expression of microRNAs (miRNAs) in lung cancer A549 cells. -tissue_expression_down hsa-mir-33a Lung Neoplasms 22325218 mir-33a was down-regulated by 92.8% and mir-193a-3p by 86.5% in epithelial-mesenchymal transition (EMT) on the expression of microRNAs (miRNAs) in lung cancer A549 cells. -tissue_expression_down hsa-mir-155 Inflammation 22326887 Glucocorticoids inhibit lipopolysaccharide-mediated inflammatory response by downregulating microRNA-155 -tissue_expression_down hsa-mir-17 Urinary Bladder Cancer 22334592 The anticancer activity of CSL in 253JB-V cells is due to induction of ROS and ROS-mediated induction of Sp repressors (ZBTB4/ZBTB10) through downregulation of miR-27a and miR-20a/17-5p. -tissue_expression_down hsa-mir-20a Urinary Bladder Cancer 22334592 The anticancer activity of CSL in 253JB-V cells is due to induction of ROS and ROS-mediated induction of Sp repressors (ZBTB4/ZBTB10) through downregulation of miR-27a and miR-20a/17-5p. -tissue_expression_down hsa-mir-27a Urinary Bladder Cancer 22334592 The anticancer activity of CSL in 253JB-V cells is due to induction of ROS and ROS-mediated induction of Sp repressors (ZBTB4/ZBTB10) through downregulation of miR-27a and miR-20a/17-5p. -tissue_expression_down hsa-mir-142 Osteosarcoma 22350417 reduced expression -tissue_expression_down hsa-mir-16-1 Osteosarcoma 22350417 reduced expression -tissue_expression_down hsa-mir-16-2 Osteosarcoma 22350417 reduced expression -tissue_expression_down hsa-mir-29b-1 Osteosarcoma 22350417 reduced expression -tissue_expression_down hsa-mir-29b-2 Osteosarcoma 22350417 reduced expression -tissue_expression_down hsa-mir-203 Burns 22360957 miR-203 was down-regulated in denatured dermis compared with those in normal skin. -tissue_expression_down hsa-mir-21 Esophageal Neoplasms 22363450 "Curcumin treatment down-regulate the expressions of Notch-1 specific microRNAs miR-21 and miR-34a, and upregulated tumor suppressor let-7a miRNA." -tissue_expression_down hsa-mir-34a Esophageal Neoplasms 22363450 "Curcumin treatment down-regulate the expressions of Notch-1 specific microRNAs miR-21 and miR-34a, and upregulated tumor suppressor let-7a miRNA." -tissue_expression_down hsa-mir-145 Gastric Neoplasms 22370644 "The authors demonstrate a stepwise downregulation of miR-145 level in nontumorous gastric mucosa, primary gastric cancers and their secondary metastases.N-cadherin (CDH2) was proved to be a direct target of miR-145" -tissue_expression_down hsa-mir-155 Myelodysplastic Syndromes 22371183 "Real-time PCR approach confirmed that mir-155, miR-181a and miR-222 were down-expressed in mesenchymal stromal cells from myelodysplastic syndrome patients." -tissue_expression_down hsa-mir-181a-1 Myelodysplastic Syndromes 22371183 "Real-time PCR approach confirmed that mir-155, miR-181a and miR-222 were down-expressed in mesenchymal stromal cells from myelodysplastic syndrome patients." -tissue_expression_down hsa-mir-181a-2 Myelodysplastic Syndromes 22371183 "Real-time PCR approach confirmed that mir-155, miR-181a and miR-222 were down-expressed in mesenchymal stromal cells from myelodysplastic syndrome patients." -tissue_expression_down hsa-mir-222 Myelodysplastic Syndromes 22371183 "Real-time PCR approach confirmed that mir-155, miR-181a and miR-222 were down-expressed in mesenchymal stromal cells from myelodysplastic syndrome patients." -tissue_expression_down hsa-let-7a-1 Gastric Neoplasms 22374783 "Real-time RT-PCR analysis demonstrated an increase in mir-21 and mir-302 expression level in CSCs(cancer stem cells), relative to cancer cells, whereas let-7a expression level was decreased in CSC in comparison with cancer cells. mir-372, mir-373 and mir-520c-5p were markedly increased in cancer cells in comparison with CSCs." -tissue_expression_down hsa-let-7a-2 Gastric Neoplasms 22374783 "Real-time RT-PCR analysis demonstrated an increase in mir-21 and mir-302 expression level in CSCs(cancer stem cells), relative to cancer cells, whereas let-7a expression level was decreased in CSC in comparison with cancer cells. mir-372, mir-373 and mir-520c-5p were markedly increased in cancer cells in comparison with CSCs." -tissue_expression_down hsa-let-7a-3 Gastric Neoplasms 22374783 "Real-time RT-PCR analysis demonstrated an increase in mir-21 and mir-302 expression level in CSCs(cancer stem cells), relative to cancer cells, whereas let-7a expression level was decreased in CSC in comparison with cancer cells. mir-372, mir-373 and mir-520c-5p were markedly increased in cancer cells in comparison with CSCs." -tissue_expression_down hsa-mir-375 Colorectal Carcinoma 22377847 miR-375 expression was frequently downregulated in the colorectal cancer tissues compared to the non-tumor counterparts -tissue_expression_down hsa-mir-183 "Carcinoma, Basal Cell" 22384406 The expression level of miR-183 was consistently lower in infiltrative than nodular tumors and could be one element underlying the difference in invasiveness. -tissue_expression_down hsa-mir-192 Urinary Bladder Cancer 22386240 "Compared with controls, the patients with bladder cancer had a lower expression of the miR-200 family, miR-192, and miR-155 in the urinary sediment; lower expression of miR-192; and higher expression of miR-155 in the urinary supernatant." -tissue_expression_down hsa-mir-200a Urinary Bladder Cancer 22386240 "Compared with controls, the patients with bladder cancer had a lower expression of the miR-200 family, miR-192, and miR-155 in the urinary sediment; lower expression of miR-192; and higher expression of miR-155 in the urinary supernatant." -tissue_expression_down hsa-mir-200b Urinary Bladder Cancer 22386240 "Compared with controls, the patients with bladder cancer had a lower expression of the miR-200 family, miR-192, and miR-155 in the urinary sediment; lower expression of miR-192; and higher expression of miR-155 in the urinary supernatant." -tissue_expression_down hsa-mir-200c Urinary Bladder Cancer 22386240 "Compared with controls, the patients with bladder cancer had a lower expression of the miR-200 family, miR-192, and miR-155 in the urinary sediment; lower expression of miR-192; and higher expression of miR-155 in the urinary supernatant." -tissue_expression_down hsa-mir-130a Prostate Neoplasms 22391564 "MiR-130a, miR-203 and miR-205 jointly repress key oncogenic pathways and are downregulated in prostate carcinoma." -tissue_expression_down hsa-mir-203 Prostate Neoplasms 22391564 "MiR-130a, miR-203 and miR-205 jointly repress key oncogenic pathways and are downregulated in prostate carcinoma." -tissue_expression_down hsa-mir-205 Prostate Neoplasms 22391564 "MiR-130a, miR-203 and miR-205 jointly repress key oncogenic pathways and are downregulated in prostate carcinoma." -tissue_expression_down hsa-mir-100 Bladder Neoplasms 22393979 Differential miRNA expression profiles in bladder urothelial carcinomas identified miR-100 down-regulation and miR-708 up-regulation among the most common alterations -tissue_expression_down hsa-mir-129-1 "Scleroderma, Systemic" 22403442 "IL-17A signaling, not IL-17F, has an antifibrogenic effect via the upregulation of miR-129-5p and the downregulation of connective tissue growth factor and §Ø©ã(I) collagen." -tissue_expression_down hsa-mir-129-2 "Scleroderma, Systemic" 22403442 "IL-17A signaling, not IL-17F, has an antifibrogenic effect via the upregulation of miR-129-5p and the downregulation of connective tissue growth factor and §Ø©ã(I) collagen." -tissue_expression_down hsa-let-7a-1 Breast Neoplasms 22403704 "Treatment with E2, BPA and DDT decreased (p<0.05) miR-21 expression. Several members of the let-7 family (let-7a, let-7b, let-7c, let-7d, let-7e and let-7f), were downregulated (p<0.05) by all three treatments.and miR-15b (p<0.005) and miR-27b (p<0.01) were also downregulated by the three treatments.upregulation of miR-638 (P<0.005), miR-663 (P<0.005), and miR-1915 (P<0.005) was observed after treatment of MCF7 cells with E2, BPA or DDT" -tissue_expression_down hsa-let-7a-2 Breast Neoplasms 22403704 "Treatment with E2, BPA and DDT decreased (p<0.05) miR-21 expression. Several members of the let-7 family (let-7a, let-7b, let-7c, let-7d, let-7e and let-7f), were downregulated (p<0.05) by all three treatments.and miR-15b (p<0.005) and miR-27b (p<0.01) were also downregulated by the three treatments.upregulation of miR-638 (P<0.005), miR-663 (P<0.005), and miR-1915 (P<0.005) was observed after treatment of MCF7 cells with E2, BPA or DDT" -tissue_expression_down hsa-let-7a-3 Breast Neoplasms 22403704 "Treatment with E2, BPA and DDT decreased (p<0.05) miR-21 expression. Several members of the let-7 family (let-7a, let-7b, let-7c, let-7d, let-7e and let-7f), were downregulated (p<0.05) by all three treatments.and miR-15b (p<0.005) and miR-27b (p<0.01) were also downregulated by the three treatments.upregulation of miR-638 (P<0.005), miR-663 (P<0.005), and miR-1915 (P<0.005) was observed after treatment of MCF7 cells with E2, BPA or DDT" -tissue_expression_down hsa-let-7b Breast Neoplasms 22403704 "Treatment with E2, BPA and DDT decreased (p<0.05) miR-21 expression. Several members of the let-7 family (let-7a, let-7b, let-7c, let-7d, let-7e and let-7f), were downregulated (p<0.05) by all three treatments.and miR-15b (p<0.005) and miR-27b (p<0.01) were also downregulated by the three treatments.upregulation of miR-638 (P<0.005), miR-663 (P<0.005), and miR-1915 (P<0.005) was observed after treatment of MCF7 cells with E2, BPA or DDT" -tissue_expression_down hsa-let-7c Breast Neoplasms 22403704 "Treatment with E2, BPA and DDT decreased (p<0.05) miR-21 expression. Several members of the let-7 family (let-7a, let-7b, let-7c, let-7d, let-7e and let-7f), were downregulated (p<0.05) by all three treatments.and miR-15b (p<0.005) and miR-27b (p<0.01) were also downregulated by the three treatments.upregulation of miR-638 (P<0.005), miR-663 (P<0.005), and miR-1915 (P<0.005) was observed after treatment of MCF7 cells with E2, BPA or DDT" -tissue_expression_down hsa-let-7d Breast Neoplasms 22403704 "Treatment with E2, BPA and DDT decreased (p<0.05) miR-21 expression. Several members of the let-7 family (let-7a, let-7b, let-7c, let-7d, let-7e and let-7f), were downregulated (p<0.05) by all three treatments.and miR-15b (p<0.005) and miR-27b (p<0.01) were also downregulated by the three treatments.upregulation of miR-638 (P<0.005), miR-663 (P<0.005), and miR-1915 (P<0.005) was observed after treatment of MCF7 cells with E2, BPA or DDT" -tissue_expression_down hsa-let-7e Breast Neoplasms 22403704 "Treatment with E2, BPA and DDT decreased (p<0.05) miR-21 expression. Several members of the let-7 family (let-7a, let-7b, let-7c, let-7d, let-7e and let-7f), were downregulated (p<0.05) by all three treatments.and miR-15b (p<0.005) and miR-27b (p<0.01) were also downregulated by the three treatments.upregulation of miR-638 (P<0.005), miR-663 (P<0.005), and miR-1915 (P<0.005) was observed after treatment of MCF7 cells with E2, BPA or DDT" -tissue_expression_down hsa-let-7f-1 Breast Neoplasms 22403704 "Treatment with E2, BPA and DDT decreased (p<0.05) miR-21 expression. Several members of the let-7 family (let-7a, let-7b, let-7c, let-7d, let-7e and let-7f), were downregulated (p<0.05) by all three treatments.and miR-15b (p<0.005) and miR-27b (p<0.01) were also downregulated by the three treatments.upregulation of miR-638 (P<0.005), miR-663 (P<0.005), and miR-1915 (P<0.005) was observed after treatment of MCF7 cells with E2, BPA or DDT" -tissue_expression_down hsa-let-7f-2 Breast Neoplasms 22403704 "Treatment with E2, BPA and DDT decreased (p<0.05) miR-21 expression. Several members of the let-7 family (let-7a, let-7b, let-7c, let-7d, let-7e and let-7f), were downregulated (p<0.05) by all three treatments.and miR-15b (p<0.005) and miR-27b (p<0.01) were also downregulated by the three treatments.upregulation of miR-638 (P<0.005), miR-663 (P<0.005), and miR-1915 (P<0.005) was observed after treatment of MCF7 cells with E2, BPA or DDT" -tissue_expression_down hsa-mir-1915 Breast Neoplasms 22403704 "Treatment with E2, BPA and DDT decreased (p<0.05) miR-21 expression. Several members of the let-7 family (let-7a, let-7b, let-7c, let-7d, let-7e and let-7f), were downregulated (p<0.05) by all three treatments.and miR-15b (p<0.005) and miR-27b (p<0.01) were also downregulated by the three treatments.upregulation of miR-638 (P<0.005), miR-663 (P<0.005), and miR-1915 (P<0.005) was observed after treatment of MCF7 cells with E2, BPA or DDT" -tissue_expression_down hsa-mir-27b Breast Neoplasms 22403704 "Treatment with E2, BPA and DDT decreased (p<0.05) miR-21 expression. Several members of the let-7 family (let-7a, let-7b, let-7c, let-7d, let-7e and let-7f), were downregulated (p<0.05) by all three treatments.and miR-15b (p<0.005) and miR-27b (p<0.01) were also downregulated by the three treatments.upregulation of miR-638 (P<0.005), miR-663 (P<0.005), and miR-1915 (P<0.005) was observed after treatment of MCF7 cells with E2, BPA or DDT" -tissue_expression_down hsa-mir-137 Glioblastoma 22406049 miR-137 is frequently down-regulated in glioblastoma and is a negative regulator of Cox-2. -tissue_expression_down hsa-mir-217 Human Immunodeficiency Virus Infection 22406815 MiR-217 is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation by down-regulation of SIRT1. -tissue_expression_down hsa-let-7f-2 Breast Neoplasms 22407818 "Aromatase inhibitor treatment of breast cancer cells increases the expression of let-7f, a microRNA targeting CYP19A1." -tissue_expression_down hsa-mir-92a-1 Prostate Neoplasms 22412975 "Isoflavone and BR-DIM down-regulated the expression of miR-92a, which is known to be associated with RANKL signaling, EMT and cancer progression." -tissue_expression_down hsa-mir-92a-2 Prostate Neoplasms 22412975 "Isoflavone and BR-DIM down-regulated the expression of miR-92a, which is known to be associated with RANKL signaling, EMT and cancer progression." -tissue_expression_down hsa-mir-100 Head And Neck Neoplasms 22425712 down-regulation -tissue_expression_down hsa-mir-375 Head And Neck Neoplasms 22425712 down-regulation -tissue_expression_down hsa-mir-99a Head And Neck Neoplasms 22425712 down-regulation -tissue_expression_down hsa-mir-155 Gastric Neoplasms 22426647 microRNA-155 is downregulated in gastric cancer cells and involved in cell metastasis. -tissue_expression_down hsa-let-7c "Carcinoma, Lung, Small-Cell" 22438992 "Downregulation of Six MicroRNAs (has-let-7c, has-miR-100, has-miR-125b, has-miR-143, has-miR-145 and has-miR-199a-5p) Is Associated with Advanced Stage, Lymph Node Metastasis and Poor Prognosis in Small Cell Carcinoma of the Cervix." -tissue_expression_down hsa-mir-100 "Carcinoma, Lung, Small-Cell" 22438992 "Downregulation of Six MicroRNAs (has-let-7c, has-miR-100, has-miR-125b, has-miR-143, has-miR-145 and has-miR-199a-5p) Is Associated with Advanced Stage, Lymph Node Metastasis and Poor Prognosis in Small Cell Carcinoma of the Cervix." -tissue_expression_down hsa-mir-125b-1 "Carcinoma, Lung, Small-Cell" 22438992 "Downregulation of Six MicroRNAs (has-let-7c, has-miR-100, has-miR-125b, has-miR-143, has-miR-145 and has-miR-199a-5p) Is Associated with Advanced Stage, Lymph Node Metastasis and Poor Prognosis in Small Cell Carcinoma of the Cervix." -tissue_expression_down hsa-mir-125b-2 "Carcinoma, Lung, Small-Cell" 22438992 "Downregulation of Six MicroRNAs (has-let-7c, has-miR-100, has-miR-125b, has-miR-143, has-miR-145 and has-miR-199a-5p) Is Associated with Advanced Stage, Lymph Node Metastasis and Poor Prognosis in Small Cell Carcinoma of the Cervix." -tissue_expression_down hsa-mir-143 "Carcinoma, Lung, Small-Cell" 22438992 "Downregulation of Six MicroRNAs (has-let-7c, has-miR-100, has-miR-125b, has-miR-143, has-miR-145 and has-miR-199a-5p) Is Associated with Advanced Stage, Lymph Node Metastasis and Poor Prognosis in Small Cell Carcinoma of the Cervix." -tissue_expression_down hsa-mir-145 "Carcinoma, Lung, Small-Cell" 22438992 "Downregulation of Six MicroRNAs (has-let-7c, has-miR-100, has-miR-125b, has-miR-143, has-miR-145 and has-miR-199a-5p) Is Associated with Advanced Stage, Lymph Node Metastasis and Poor Prognosis in Small Cell Carcinoma of the Cervix." -tissue_expression_down hsa-mir-199a-1 "Carcinoma, Lung, Small-Cell" 22438992 "Downregulation of Six MicroRNAs (has-let-7c, has-miR-100, has-miR-125b, has-miR-143, has-miR-145 and has-miR-199a-5p) Is Associated with Advanced Stage, Lymph Node Metastasis and Poor Prognosis in Small Cell Carcinoma of the Cervix." -tissue_expression_down hsa-mir-199a-2 "Carcinoma, Lung, Small-Cell" 22438992 "Downregulation of Six MicroRNAs (has-let-7c, has-miR-100, has-miR-125b, has-miR-143, has-miR-145 and has-miR-199a-5p) Is Associated with Advanced Stage, Lymph Node Metastasis and Poor Prognosis in Small Cell Carcinoma of the Cervix." -tissue_expression_down hsa-mir-140 Ovarian Neoplasms 22452920 "The expression level of RAD51AP1 was found to be strongly anti-correlated with the expression of hsa-miR-140-3p, which was significantly down-regulated in the tumour samples." -tissue_expression_down hsa-mir-15a Multiple Sclerosis 22463747 miR-15a and 16-1 are downregulated in CD4(+) T cells of multiple sclerosis relapsing patients. -tissue_expression_down hsa-mir-16-1 Multiple Sclerosis 22463747 miR-15a and 16-1 are downregulated in CD4(+) T cells of multiple sclerosis relapsing patients. -tissue_expression_down hsa-mir-215 Colorectal Carcinoma 22469014 "MiR-215, miR-375, miR-378 and miR-422a were significantly decreased, whereas miR-135b was increased in CRC tumor tissues. Levels of miR-215 and miR-422a correlated with clinical stage." -tissue_expression_down hsa-mir-378a Colorectal Carcinoma 22469014 "MiR-215, miR-375, miR-378 and miR-422a were significantly decreased, whereas miR-135b was increased in CRC tumor tissues. Levels of miR-215 and miR-422a correlated with clinical stage." -tissue_expression_down hsa-mir-422a Colorectal Carcinoma 22469014 "MiR-215, miR-375, miR-378 and miR-422a were significantly decreased, whereas miR-135b was increased in CRC tumor tissues. Levels of miR-215 and miR-422a correlated with clinical stage." -tissue_expression_down hsa-mir-125b-1 Prolactinoma 22490835 down-regulated -tissue_expression_down hsa-mir-125b-2 Prolactinoma 22490835 down-regulated -tissue_expression_down hsa-mir-130a Prolactinoma 22490835 down-regulated -tissue_expression_down hsa-mir-199b Prolactinoma 22490835 miR-199b-3p: down-regulated -tissue_expression_down hsa-mir-200b Prolactinoma 22490835 down-regulated -tissue_expression_down hsa-mir-22 Colorectal Carcinoma 22492279 "The relative expression levels of miR-22 were significantly lower in colorectal cancer tissues than those in the normal adjacent mucosa, and low expression of miR-22 correlated with liver metastasis. Kaplan-Meier analysis indicated that patients with reduced miR-22 had a poor overall survival." -tissue_expression_down hsa-mir-10b "Carcinoma, Renal Cell" 22492545 "Expression levels of miR-143, miR-26a, miR-145, miR-10b, miR-195, and miR-126 are lower in the tumors of RCC patients who developed tumor relapse." -tissue_expression_down hsa-mir-126 "Carcinoma, Renal Cell" 22492545 "Expression levels of miR-143, miR-26a, miR-145, miR-10b, miR-195, and miR-126 are lower in the tumors of RCC patients who developed tumor relapse." -tissue_expression_down hsa-mir-143 "Carcinoma, Renal Cell" 22492545 "Expression levels of miR-143, miR-26a, miR-145, miR-10b, miR-195, and miR-126 are lower in the tumors of RCC patients who developed tumor relapse." -tissue_expression_down hsa-mir-145 "Carcinoma, Renal Cell" 22492545 "Expression levels of miR-143, miR-26a, miR-145, miR-10b, miR-195, and miR-126 are lower in the tumors of RCC patients who developed tumor relapse." -tissue_expression_down hsa-mir-195 "Carcinoma, Renal Cell" 22492545 "Expression levels of miR-143, miR-26a, miR-145, miR-10b, miR-195, and miR-126 are lower in the tumors of RCC patients who developed tumor relapse." -tissue_expression_down hsa-mir-26a-1 "Carcinoma, Renal Cell" 22492545 "Expression levels of miR-143, miR-26a, miR-145, miR-10b, miR-195, and miR-126 are lower in the tumors of RCC patients who developed tumor relapse." -tissue_expression_down hsa-mir-26a-2 "Carcinoma, Renal Cell" 22492545 "Expression levels of miR-143, miR-26a, miR-145, miR-10b, miR-195, and miR-126 are lower in the tumors of RCC patients who developed tumor relapse." -tissue_expression_down hsa-mir-106b Neuroblastoma 22498172 "Combination of 4-HPR (N-(4-hydroxyphenyl) retinamide) and EGCG ((-)-epigallocatechin-3-gallate) most significantly decreased expression of OGmiRs (miR-92, miR-93, and miR-106b) and increased expression of TSmiRs (miR-7-1, miR-34a, and miR-99a) in both cell lines(SK-N-BE2 and IMR-32 cells)" -tissue_expression_down hsa-mir-92a-1 Neuroblastoma 22498172 "Combination of 4-HPR (N-(4-hydroxyphenyl) retinamide) and EGCG ((-)-epigallocatechin-3-gallate) most significantly decreased expression of OGmiRs (miR-92, miR-93, and miR-106b) and increased expression of TSmiRs (miR-7-1, miR-34a, and miR-99a) in both cell lines(SK-N-BE2 and IMR-32 cells)" -tissue_expression_down hsa-mir-92a-2 Neuroblastoma 22498172 "Combination of 4-HPR (N-(4-hydroxyphenyl) retinamide) and EGCG ((-)-epigallocatechin-3-gallate) most significantly decreased expression of OGmiRs (miR-92, miR-93, and miR-106b) and increased expression of TSmiRs (miR-7-1, miR-34a, and miR-99a) in both cell lines(SK-N-BE2 and IMR-32 cells)" -tissue_expression_down hsa-mir-92b Neuroblastoma 22498172 "Combination of 4-HPR (N-(4-hydroxyphenyl) retinamide) and EGCG ((-)-epigallocatechin-3-gallate) most significantly decreased expression of OGmiRs (miR-92, miR-93, and miR-106b) and increased expression of TSmiRs (miR-7-1, miR-34a, and miR-99a) in both cell lines(SK-N-BE2 and IMR-32 cells)" -tissue_expression_down hsa-mir-93 Neuroblastoma 22498172 "Combination of 4-HPR (N-(4-hydroxyphenyl) retinamide) and EGCG ((-)-epigallocatechin-3-gallate) most significantly decreased expression of OGmiRs (miR-92, miR-93, and miR-106b) and increased expression of TSmiRs (miR-7-1, miR-34a, and miR-99a) in both cell lines(SK-N-BE2 and IMR-32 cells)" -tissue_expression_down hsa-mir-155 "Leukemia, Myeloid, Chronic" 22511990 "Downregulation of mir-31, mir-155, and mir-564 in chronic myeloid leukemia cells." -tissue_expression_down hsa-mir-31 "Leukemia, Myeloid, Chronic" 22511990 "Downregulation of mir-31, mir-155, and mir-564 in chronic myeloid leukemia cells." -tissue_expression_down hsa-mir-564 "Leukemia, Myeloid, Chronic" 22511990 "Downregulation of mir-31, mir-155, and mir-564 in chronic myeloid leukemia cells." -tissue_expression_down hsa-mir-126 Breast Neoplasms 22524830 "down regulation in mir-17p, mir-126, mir-335, mir-30b" -tissue_expression_down hsa-mir-17 Breast Neoplasms 22524830 "down regulation in mir-17p, mir-126, mir-335, mir-30b" -tissue_expression_down hsa-mir-30b Breast Neoplasms 22524830 "down regulation in mir-17p, mir-126, mir-335, mir-30b" -tissue_expression_down hsa-mir-335 Breast Neoplasms 22524830 "down regulation in mir-17p, mir-126, mir-335, mir-30b" -tissue_expression_down hsa-mir-675 Osteoarthritis 22527881 "Proinflammatory cytokines IL-1beta and TNF-alpha downregulated COL2A1, H19, and miR-675 significantly without close statistical correlation." -tissue_expression_down hsa-mir-133b Prostate Neoplasms 22532850 "Expression of miR-133b in tumor specimens of prostate cancer patients was significantly downregulated in 75% of the cases, when compared with matched healthy tissue." -tissue_expression_down hsa-mir-181a-2 Coronary Artery Disease 22535975 Decreased miR-181a Expression in Monocytes of Obese Patients Is Associated with the Occurrence of Metabolic Syndrome and Coronary Artery Disease. -tissue_expression_down hsa-mir-129-1 "Carcinoma, Hepatocellular" 22536440 "VCP/p97, down-regulated by microRNA-129-5p, could regulate the progression of hepatocellular carcinoma." -tissue_expression_down hsa-mir-129-2 "Carcinoma, Hepatocellular" 22536440 "VCP/p97, down-regulated by microRNA-129-5p, could regulate the progression of hepatocellular carcinoma." -tissue_expression_down hsa-mir-139 "Carcinoma, Basal Cell" 22540308 miR-139-5p is downregulated in the tumor center -tissue_expression_down hsa-mir-140 "Carcinoma, Basal Cell" 22540308 miR-140-3p is downregulated in the tumor center -tissue_expression_down hsa-mir-145 "Carcinoma, Basal Cell" 22540308 downregulated in the tumor center -tissue_expression_down hsa-mir-2861 "Carcinoma, Basal Cell" 22540308 downregulated in the tumor center -tissue_expression_down hsa-mir-29c "Carcinoma, Basal Cell" 22540308 miR-29c and miR-29c* are downregulated in the tumor center -tissue_expression_down hsa-mir-3196 "Carcinoma, Basal Cell" 22540308 downregulated in the tumor center -tissue_expression_down hsa-mir-378a "Carcinoma, Basal Cell" 22540308 downregulated in the tumor center -tissue_expression_down hsa-mir-378b "Carcinoma, Basal Cell" 22540308 downregulated in the tumor center -tissue_expression_down hsa-mir-378c "Carcinoma, Basal Cell" 22540308 downregulated in the tumor center -tissue_expression_down hsa-mir-378d-1 "Carcinoma, Basal Cell" 22540308 downregulated in the tumor center -tissue_expression_down hsa-mir-378d-2 "Carcinoma, Basal Cell" 22540308 downregulated in the tumor center -tissue_expression_down hsa-mir-378e "Carcinoma, Basal Cell" 22540308 downregulated in the tumor center -tissue_expression_down hsa-mir-378f "Carcinoma, Basal Cell" 22540308 downregulated in the tumor center -tissue_expression_down hsa-mir-378g "Carcinoma, Basal Cell" 22540308 downregulated in the tumor center -tissue_expression_down hsa-mir-378h "Carcinoma, Basal Cell" 22540308 downregulated in the tumor center -tissue_expression_down hsa-mir-378i "Carcinoma, Basal Cell" 22540308 downregulated in the tumor center -tissue_expression_down hsa-mir-572 "Carcinoma, Basal Cell" 22540308 downregulated in the tumor center -tissue_expression_down hsa-mir-638 "Carcinoma, Basal Cell" 22540308 downregulated in the tumor center -tissue_expression_down hsa-mir-193b Endometrial Neoplasms 22543862 Decreased expression after Progesterone Treatment. -tissue_expression_down hsa-mir-29c Endometrial Neoplasms 22543862 Decreased expression after Progesterone Treatment. -tissue_expression_down hsa-mir-633 Endometrial Neoplasms 22543862 Decreased expression after Progesterone Treatment. -tissue_expression_down hsa-mir-138-1 Melanoma 22551973 The downregulation of this miRNA was associated with selective genomic loss in SSM cell lines and primary tumors. -tissue_expression_down hsa-mir-138-2 Melanoma 22551973 The downregulation of this miRNA was associated with selective genomic loss in SSM cell lines and primary tumors. -tissue_expression_down hsa-mir-15a Melanoma 22551973 The downregulation of this miRNA was associated with selective genomic loss in SSM cell lines and primary tumors. -tissue_expression_down hsa-mir-16-1 Melanoma 22551973 The downregulation of this miRNA was associated with selective genomic loss in SSM cell lines and primary tumors. -tissue_expression_down hsa-mir-16-2 Melanoma 22551973 The downregulation of this miRNA was associated with selective genomic loss in SSM cell lines and primary tumors. -tissue_expression_down hsa-mir-181a-1 Melanoma 22551973 The downregulation of this miRNA was associated with selective genomic loss in SSM cell lines and primary tumors. -tissue_expression_down hsa-mir-181a-2 Melanoma 22551973 The downregulation of this miRNA was associated with selective genomic loss in SSM cell lines and primary tumors. -tissue_expression_down hsa-mir-191 Melanoma 22551973 The downregulation of this miRNA was associated with selective genomic loss in SSM cell lines and primary tumors. -tissue_expression_down hsa-mir-933 Melanoma 22551973 The downregulation of this miRNA was associated with selective genomic loss in SSM cell lines and primary tumors. -tissue_expression_down hsa-mir-155 Asthma 22558995 The decreased expression level of miR-155 is correlated to asthma disease severity. -tissue_expression_down hsa-mir-16-1 Breast Neoplasms 22583478 Downregulation of the tumor-suppressor miR-16 via progestin-mediated oncogenic signaling contributes to breast cancer development. -tissue_expression_down hsa-mir-125b-1 Laryngeal Neoplasms 22605671 Downregulation -tissue_expression_down hsa-mir-125b-2 Laryngeal Neoplasms 22605671 Downregulation -tissue_expression_down hsa-mir-145 Laryngeal Neoplasms 22605671 Downregulation -tissue_expression_down hsa-mir-214 "Carcinoma, Hepatocellular" 22613005 MicroRNA-214 downregulation contributes to tumor angiogenesis by inducing secretion of the hepatoma-derived growth factor in human hepatoma. -tissue_expression_down hsa-let-7e "Carcinoma, Lung, Non-Small-Cell" 22618509 "We showed that, compared to adjacent non-neoplastic lung tissues, the expressions of miR-125a-5p and let-7e were decreased in AD and SCC samples" -tissue_expression_down hsa-mir-125a "Carcinoma, Lung, Non-Small-Cell" 22618509 "We showed that, compared to adjacent non-neoplastic lung tissues, the expressions of miR-125a-5p and let-7e were decreased in AD and SCC samples" -tissue_expression_down hsa-mir-34a Breast Neoplasms 22623155 MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1. -tissue_expression_down hsa-mir-34a "Squamous Cell Carcinoma, Sinonasal" 22624980 miR-34a is downregulated in cis-diamminedichloroplatinum treated sinonasal squamous cell carcinoma patients with poor prognosis. -tissue_expression_down hsa-mir-1202 Ovarian Neoplasms 22643117 "We found 37 differentially expressed miRNAs in the CD133(+) spheroid-forming subpopulation of OVCAR3 cells, 34 of which were significantly up-regulated, including miR-205, miR-146a, miR-200a, miR-200b, and miR-3, and 3 of which were significantly down-regulated, including miR-1202 and miR-1181." -tissue_expression_down hsa-mir-1281 Ovarian Neoplasms 22643117 "We found 37 differentially expressed miRNAs in the CD133(+) spheroid-forming subpopulation of OVCAR3 cells, 34 of which were significantly up-regulated, including miR-205, miR-146a, miR-200a, miR-200b, and miR-3, and 3 of which were significantly down-regulated, including miR-1202 and miR-1181." -tissue_expression_down hsa-mir-126 Lung Neoplasms 22672859 "Four up-regulated microRNAs (miR-210, miR-21, miR-31 and miR-182) and two down-regulated mcroiRNAs (miR-126 and miR-145) were consistently reported both in squamous carcinoma and adenocarcinoma-based subgroup analysis" -tissue_expression_down hsa-mir-145 Lung Neoplasms 22672859 "Four up-regulated microRNAs (miR-210, miR-21, miR-31 and miR-182) and two down-regulated mcroiRNAs (miR-126 and miR-145) were consistently reported both in squamous carcinoma and adenocarcinoma-based subgroup analysis" -tissue_expression_down hsa-mir-133a-1 Astrocytoma 22674182 Significantly decreased in grades II-IV patients. -tissue_expression_down hsa-mir-133a-2 Astrocytoma 22674182 Significantly decreased in grades II-IV patients. -tissue_expression_down hsa-mir-150 Astrocytoma 22674182 miR-150*:Significantly decreased in grades II-IV patients. -tissue_expression_down hsa-mir-15b Astrocytoma 22674182 miR-15b*: Significantly decreased in grades II-IV patients. -tissue_expression_down hsa-mir-197 Astrocytoma 22674182 Significantly decreased in grades II-IV patients. -tissue_expression_down hsa-mir-23a Astrocytoma 22674182 Significantly decreased in grades II-IV patients. -tissue_expression_down hsa-mir-497 Astrocytoma 22674182 Significantly decreased in grades II-IV patients. -tissue_expression_down hsa-mir-548b Astrocytoma 22674182 miR-548b-5p: Significantly decreased in grades II-IV patients. -tissue_expression_down hsa-mir-219 Meningioma 22674195 Downregulation of miR-29c-3p and miR-219-5p were found to be associated with advanced clinical stages of meningioma. Kaplan-Meier analysis showed that high expression of miR-190a and low expression of miR-29c-3p and miR-219-5p correlated significantly with higher recurrence rates in meningioma patients. -tissue_expression_down hsa-mir-29c Meningioma 22674195 Downregulation of miR-29c-3p and miR-219-5p were found to be associated with advanced clinical stages of meningioma. Kaplan-Meier analysis showed that high expression of miR-190a and low expression of miR-29c-3p and miR-219-5p correlated significantly with higher recurrence rates in meningioma patients. -tissue_expression_down hsa-mir-182 "Carcinoma, Hepatocellular" 22681717 MicroRNA-182 downregulates metastasis suppressor 1 and contributes to metastasis of hepatocellular carcinoma. -tissue_expression_down hsa-mir-100 Chronic Obstructive Pulmonary Disease 22686440 "There was down-regulation of miR-20a, miR-28-3p, miR-34c-5p, and miR-100, and up-regulation of miR-7, compared with the controls." -tissue_expression_down hsa-mir-20a Chronic Obstructive Pulmonary Disease 22686440 "There was down-regulation of miR-20a, miR-28-3p, miR-34c-5p, and miR-100, and up-regulation of miR-7, compared with the controls." -tissue_expression_down hsa-mir-28 Chronic Obstructive Pulmonary Disease 22686440 "There was down-regulation of miR-20a, miR-28-3p, miR-34c-5p, and miR-100, and up-regulation of miR-7, compared with the controls." -tissue_expression_down hsa-mir-34c Chronic Obstructive Pulmonary Disease 22686440 "There was down-regulation of miR-20a, miR-28-3p, miR-34c-5p, and miR-100, and up-regulation of miR-7, compared with the controls." -tissue_expression_down hsa-mir-7-1 Chronic Obstructive Pulmonary Disease 22686440 "There was down-regulation of miR-20a, miR-28-3p, miR-34c-5p, and miR-100, and up-regulation of miR-7, compared with the controls." -tissue_expression_down hsa-mir-7-2 Chronic Obstructive Pulmonary Disease 22686440 "There was down-regulation of miR-20a, miR-28-3p, miR-34c-5p, and miR-100, and up-regulation of miR-7, compared with the controls." -tissue_expression_down hsa-mir-7-3 Chronic Obstructive Pulmonary Disease 22686440 "There was down-regulation of miR-20a, miR-28-3p, miR-34c-5p, and miR-100, and up-regulation of miR-7, compared with the controls." -tissue_expression_down hsa-mir-10b Urinary Bladder Cancer 22704449 "miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium." -tissue_expression_down hsa-mir-126 Urinary Bladder Cancer 22704449 "miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium." -tissue_expression_down hsa-mir-145 Urinary Bladder Cancer 22704449 "miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium." -tissue_expression_down hsa-mir-19a Urinary Bladder Cancer 22704449 "miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium." -tissue_expression_down hsa-mir-221 Urinary Bladder Cancer 22704449 "miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium." -tissue_expression_down hsa-mir-296 Urinary Bladder Cancer 22704449 "miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium." -tissue_expression_down hsa-mir-378a Urinary Bladder Cancer 22704449 "miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium." -tissue_expression_down hsa-mir-378b Urinary Bladder Cancer 22704449 "miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium." -tissue_expression_down hsa-mir-378c Urinary Bladder Cancer 22704449 "miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium." -tissue_expression_down hsa-mir-378d-1 Urinary Bladder Cancer 22704449 "miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium." -tissue_expression_down hsa-mir-378d-2 Urinary Bladder Cancer 22704449 "miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium." -tissue_expression_down hsa-mir-378e Urinary Bladder Cancer 22704449 "miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium." -tissue_expression_down hsa-mir-378f Urinary Bladder Cancer 22704449 "miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium." -tissue_expression_down hsa-mir-378g Urinary Bladder Cancer 22704449 "miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium." -tissue_expression_down hsa-mir-378h Urinary Bladder Cancer 22704449 "miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium." -tissue_expression_down hsa-mir-378i Urinary Bladder Cancer 22704449 "miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium." -tissue_expression_down hsa-mir-325 Preeclampsia 22710575 The expression of hsa-miR-325 was downregulated in the case of PE. Changes in hsa-miR-325 expression in the case of pregnancy-related hypertensive disorders might affect the oxidative stress pathways and heat-shock protein production. -tissue_expression_down hsa-mir-199a-1 "Carcinoma, Hepatocellular" 22713463 Cisplatin-induced downregulation of miR-199a-5p increases drug resistance by activating autophagy in HCC cell. -tissue_expression_down hsa-mir-199a-2 "Carcinoma, Hepatocellular" 22713463 Cisplatin-induced downregulation of miR-199a-5p increases drug resistance by activating autophagy in HCC cell. -tissue_expression_down hsa-mir-106a Prostate Neoplasms 22719071 downregulated in prostate cancer stem/progenitor cell. -tissue_expression_down hsa-mir-141 Prostate Neoplasms 22719071 downregulated in prostate cancer stem/progenitor cell. -tissue_expression_down hsa-mir-34a Prostate Neoplasms 22719071 downregulated in prostate cancer stem/progenitor cell. -tissue_expression_down hsa-mir-125b-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 22723551 The downregulation of miR-125b in chronic lymphocytic leukemias leads to metabolic adaptation of cells to a transformed state. -tissue_expression_down hsa-mir-125b-2 "Leukemia, Lymphocytic, Chronic, B-Cell" 22723551 The downregulation of miR-125b in chronic lymphocytic leukemias leads to metabolic adaptation of cells to a transformed state. -tissue_expression_down hsa-mir-31 Colorectal Carcinoma 22740910 "Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas." -tissue_expression_down hsa-mir-99a "Carcinoma, Oral" 22751686 Downregulation of microRNA 99a in oral squamous cell carcinomas contributes to the growth and survival of oral cancer cells. -tissue_expression_down hsa-mir-650 "Carcinoma, Hepatocellular" 22767438 Upregulation of miR-650 is correlated with down-regulation of ING4 and progression of hepatocellular carcinoma. -tissue_expression_down hsa-mir-125b-1 Myotonic Muscular Dystrophy 22768114 miR-125b-5p: decreased levels compared to controls -tissue_expression_down hsa-mir-193a Myotonic Muscular Dystrophy 22768114 miR-193a-3p: decreased levels compared to controls -tissue_expression_down hsa-mir-193b Myotonic Muscular Dystrophy 22768114 miR-193b-3p: decreased levels compared to controls -tissue_expression_down hsa-mir-378a Myotonic Muscular Dystrophy 22768114 miR-378a-3p: decreased levels compared to controls -tissue_expression_down hsa-let-7e Interstitial Lung Disease 22782705 downregulated -tissue_expression_down hsa-mir-142 Interstitial Lung Disease 22782705 miR-142-5p: downregulated -tissue_expression_down hsa-mir-19a Interstitial Lung Disease 22782705 downregulated -tissue_expression_down hsa-mir-195 Breast Neoplasms 22800791 "The levels of miR-195 in the breast cancer with histological high grade, tumor size of T3-4, lymph nodal involvement or vessel invasion were significantly down-regulated, compared with those of patients with histological low grade (Z = -2.271, P = 0.023), tumor size of T1-2 (Z = -2.687, P = 0.007), no lymph node metastasis (Z = -1.967, P = 0.049) and vessel invasion (Z = -2.432, P = 0.015)." -tissue_expression_down hsa-mir-26b Head And Neck Neoplasms 22811001 "In addition, the expression levels of miR-21 and miR-26b were both reduced in post-operative HNSCC patients with good prognosis." -tissue_expression_down hsa-mir-22 Prostate Neoplasms 22815235 "We previously detected several miRNAs, for example, miR-24 and miR-22, as significantly downregulated in Pca" -tissue_expression_down hsa-mir-24 Prostate Neoplasms 22815235 "We previously detected several miRNAs, for example, miR-24 and miR-22, as significantly downregulated in Pca" -tissue_expression_down hsa-mir-155 Behcet Disease 22815348 Decreased microRNA-155 Expression in Ocular Behcet's Disease but Not in Vogt Koyanagi Harada Syndrome. -tissue_expression_down hsa-let-7i Pancreatic Neoplasms 22820191 "Knockdown of Dicer 1 expression in BxPC-3 and Panc-1 cells resulted in significant increases in KRAS, p53, PTEN, and Dnmts protein levels and significant decreases in miR-22, miR-143, let-7i, and miR-29b expression." -tissue_expression_down hsa-mir-143 Pancreatic Neoplasms 22820191 "Knockdown of Dicer 1 expression in BxPC-3 and Panc-1 cells resulted in significant increases in KRAS, p53, PTEN, and Dnmts protein levels and significant decreases in miR-22, miR-143, let-7i, and miR-29b expression." -tissue_expression_down hsa-mir-22 Pancreatic Neoplasms 22820191 "Knockdown of Dicer 1 expression in BxPC-3 and Panc-1 cells resulted in significant increases in KRAS, p53, PTEN, and Dnmts protein levels and significant decreases in miR-22, miR-143, let-7i, and miR-29b expression." -tissue_expression_down hsa-mir-29b Pancreatic Neoplasms 22820191 "Knockdown of Dicer 1 expression in BxPC-3 and Panc-1 cells resulted in significant increases in KRAS, p53, PTEN, and Dnmts protein levels and significant decreases in miR-22, miR-143, let-7i, and miR-29b expression." -tissue_expression_down hsa-mir-200b Pancreatic Neoplasms 22821831 "Furthermore, MIF-overexpression significantly increased ZEB1/2 and decreased miR-200b expression, while shRNA-mediated inhibition of MIF increased E-cadherin and miR-200b expression, and reduced the expression of ZEB1/2 in Panc1 cells." -tissue_expression_down hsa-mir-145 "Carcinoma, Lung, Non-Small-Cell" 22835608 Low miR-145 and high miR-367 are associated with unfavorable prognosis in resected NSCLC. -tissue_expression_down hsa-mir-124-1 Sepsis 22846781 Corticosteroid resistance in sepsis is influenced by microRNA-124-induced downregulation of glucocorticoid receptor-alpha -tissue_expression_down hsa-mir-124-2 Sepsis 22846781 Corticosteroid resistance in sepsis is influenced by microRNA-124-induced downregulation of glucocorticoid receptor-alpha -tissue_expression_down hsa-mir-195 Melanoma 22847610 miR-195-mediated downregulation of WEE1 in metastatic lesions may help to overcome cell cycle arrest under stress conditions in the local tissue microenvironment to allow unrestricted growth of tumour cells. -tissue_expression_down hsa-let-7b Esophageal Neoplasms 22847808 "Low expression of let-7b and let-7c in before-treatment biopsies from 74 patients of the training set correlated significantly with poor response to chemotherapy, both clinically and histopathologically." -tissue_expression_down hsa-let-7c Esophageal Neoplasms 22847808 "Low expression of let-7b and let-7c in before-treatment biopsies from 74 patients of the training set correlated significantly with poor response to chemotherapy, both clinically and histopathologically." -tissue_expression_down hsa-mir-122 Pancreatic Neoplasms 22850622 "miR-21, miR-155, miR-210, miR-221, and miR-222, were overexpressed in diseased tissues than in the control samples, whereas miR-31, miR-122, miR-145, and miR-146a were underexpressed." -tissue_expression_down hsa-mir-145 Pancreatic Neoplasms 22850622 "miR-21, miR-155, miR-210, miR-221, and miR-222, were overexpressed in diseased tissues than in the control samples, whereas miR-31, miR-122, miR-145, and miR-146a were underexpressed." -tissue_expression_down hsa-mir-146a Pancreatic Neoplasms 22850622 "miR-21, miR-155, miR-210, miR-221, and miR-222, were overexpressed in diseased tissues than in the control samples, whereas miR-31, miR-122, miR-145, and miR-146a were underexpressed." -tissue_expression_down hsa-mir-31 Pancreatic Neoplasms 22850622 "miR-21, miR-155, miR-210, miR-221, and miR-222, were overexpressed in diseased tissues than in the control samples, whereas miR-31, miR-122, miR-145, and miR-146a were underexpressed." -tissue_expression_down hsa-mir-513a-1 Retinoblastoma 22886978 miR-513a-5p expression was decreased in Rb cells after etoposide treatment. -tissue_expression_down hsa-mir-513a-2 Retinoblastoma 22886978 miR-513a-5p expression was decreased in Rb cells after etoposide treatment. -tissue_expression_down hsa-mir-513b Retinoblastoma 22886978 miR-513a-5p expression was decreased in Rb cells after etoposide treatment. -tissue_expression_down hsa-mir-513c Retinoblastoma 22886978 miR-513a-5p expression was decreased in Rb cells after etoposide treatment. -tissue_expression_down hsa-mir-125b-1 Breast Neoplasms 22898264 "Upregulation of miR-21 and miR-191 and downregulation of miR-125b, was found in breast cancer tissue." -tissue_expression_down hsa-mir-125b-2 Breast Neoplasms 22898264 "Upregulation of miR-21 and miR-191 and downregulation of miR-125b, was found in breast cancer tissue." -tissue_expression_down hsa-mir-191 Breast Neoplasms 22898264 "Upregulation of miR-21 and miR-191 and downregulation of miR-125b, was found in breast cancer tissue." -tissue_expression_down hsa-mir-21 Breast Neoplasms 22898264 "Upregulation of miR-21 and miR-191 and downregulation of miR-125b, was found in breast cancer tissue." -tissue_expression_down hsa-mir-1308 Melanoma 22898827 "we assayed the MITF-KD miRNA profiles using a miRNA microarray and found that hsa-miR-1225-3p, hsa-miR-634, hsa-miR-197, hsa-miR-766, hsa-miR-574-5p and hsa-miR-328 were upregulated, and hsa-miR-720 and hsa-miR-1308 were downregulated in MITF knocked down melanocytes." -tissue_expression_down hsa-mir-720 Melanoma 22898827 "we assayed the MITF-KD miRNA profiles using a miRNA microarray and found that hsa-miR-1225-3p, hsa-miR-634, hsa-miR-197, hsa-miR-766, hsa-miR-574-5p and hsa-miR-328 were upregulated, and hsa-miR-720 and hsa-miR-1308 were downregulated in MITF knocked down melanocytes." -tissue_expression_down hsa-mir-19b-2 "Tuberculosis, Pulmonary" 22900099 miR-19b-2*: Underexpression -tissue_expression_down hsa-mir-199a-1 Colorectal Carcinoma 22903020 "miR-199a-5p was expressed at a low level in human primary colonic epithelial cells treated with deoxycholic acid compared with control, and miR-199a-5p was significantly down-regulated in colorectal cancer tissues.CAC1 was a direct miR-199a-5p target.The high miR-199a-5p expression and low CAC1 protein expression reverse the tumor cell drug resistance." -tissue_expression_down hsa-mir-199a-2 Colorectal Carcinoma 22903020 "miR-199a-5p was expressed at a low level in human primary colonic epithelial cells treated with deoxycholic acid compared with control, and miR-199a-5p was significantly down-regulated in colorectal cancer tissues.CAC1 was a direct miR-199a-5p target.The high miR-199a-5p expression and low CAC1 protein expression reverse the tumor cell drug resistance." -tissue_expression_down hsa-mir-143 Pancreatic Neoplasms 22905187 "miR-216a, -196a, -143 und -155) were detected at lower concentrations in feces of PCA patients when compared to controls (p<0.05)." -tissue_expression_down hsa-mir-155 Pancreatic Neoplasms 22905187 "miR-216a, -196a, -143 und -155) were detected at lower concentrations in feces of PCA patients when compared to controls (p<0.05)." -tissue_expression_down hsa-mir-196a-1 Pancreatic Neoplasms 22905187 "miR-216a, -196a, -143 und -155) were detected at lower concentrations in feces of PCA patients when compared to controls (p<0.05)." -tissue_expression_down hsa-mir-196a-2 Pancreatic Neoplasms 22905187 "miR-216a, -196a, -143 und -155) were detected at lower concentrations in feces of PCA patients when compared to controls (p<0.05)." -tissue_expression_down hsa-mir-216a Pancreatic Neoplasms 22905187 "miR-216a, -196a, -143 und -155) were detected at lower concentrations in feces of PCA patients when compared to controls (p<0.05)." -tissue_expression_down hsa-mir-129-1 Breast Neoplasms 22907300 "miR-129 is found to significantly inhibit the migration of MDA-MB-231 both in Transwell migration assay and wound healing assay. Furthermore, miR-129 also shows great suppressive ability to cell mobility and migration in another two breast cancer cell lines BT549 and MDA-MB-435s. Most importantly, miR-129 is down-regulated both in breast cancer tissues compared with the paired adjacent normal breast tissues, and in breast cancer cell lines compared with normal breast epithelial cell MCF10A (P < 0.05)." -tissue_expression_down hsa-mir-129-2 Breast Neoplasms 22907300 "miR-129 is found to significantly inhibit the migration of MDA-MB-231 both in Transwell migration assay and wound healing assay. Furthermore, miR-129 also shows great suppressive ability to cell mobility and migration in another two breast cancer cell lines BT549 and MDA-MB-435s. Most importantly, miR-129 is down-regulated both in breast cancer tissues compared with the paired adjacent normal breast tissues, and in breast cancer cell lines compared with normal breast epithelial cell MCF10A (P < 0.05)." -tissue_expression_down hsa-mir-100 Endometrial Neoplasms 22920721 "Deregulation of miR-100, miR-99a and miR-199b in tissues and plasma coexists with increased expression of mTOR kinase in endometrioid endometrial carcinoma." -tissue_expression_down hsa-mir-128-1 Glioblastoma 22922228 "Platelet-derived growth factor-B (PDGF-B), a potent angiogenic growth factor involved in GBM development and progression, promotes downregulation of pro-oncogenic (miR-21) and anti-oncogenic (miR-128) miRNAs in GBM pathology." -tissue_expression_down hsa-mir-128-2 Glioblastoma 22922228 "Platelet-derived growth factor-B (PDGF-B), a potent angiogenic growth factor involved in GBM development and progression, promotes downregulation of pro-oncogenic (miR-21) and anti-oncogenic (miR-128) miRNAs in GBM pathology." -tissue_expression_down hsa-mir-21 Glioblastoma 22922228 "Platelet-derived growth factor-B (PDGF-B), a potent angiogenic growth factor involved in GBM development and progression, promotes downregulation of pro-oncogenic (miR-21) and anti-oncogenic (miR-128) miRNAs in GBM pathology." -tissue_expression_down hsa-mir-124 Glioblastoma 22929615 "We tested two predicted proneural drivers, miR-124 and miR-132, both underexpressed in proneural tumors, by overexpression in neurospheres and observed a partial reversal of corresponding tumor expression changes." -tissue_expression_down hsa-mir-132 Glioblastoma 22929615 "We tested two predicted proneural drivers, miR-124 and miR-132, both underexpressed in proneural tumors, by overexpression in neurospheres and observed a partial reversal of corresponding tumor expression changes." -tissue_expression_down hsa-let-7c Pancreatic Neoplasms 22929886 "The expression of let-7c, let-7f, and miR-200c were significantly reduced in most patients whereas the expression of miR-486-5p and miR-451 were significantly elevated in all pancreas cancer patients." -tissue_expression_down hsa-let-7f-1 Pancreatic Neoplasms 22929886 "The expression of let-7c, let-7f, and miR-200c were significantly reduced in most patients whereas the expression of miR-486-5p and miR-451 were significantly elevated in all pancreas cancer patients." -tissue_expression_down hsa-let-7f-2 Pancreatic Neoplasms 22929886 "The expression of let-7c, let-7f, and miR-200c were significantly reduced in most patients whereas the expression of miR-486-5p and miR-451 were significantly elevated in all pancreas cancer patients." -tissue_expression_down hsa-mir-200c Pancreatic Neoplasms 22929886 "The expression of let-7c, let-7f, and miR-200c were significantly reduced in most patients whereas the expression of miR-486-5p and miR-451 were significantly elevated in all pancreas cancer patients." -tissue_expression_down hsa-mir-223 Inflammation 22937006 Here we reported that the expression of microRNA-223 (miR-223) was significantly decreased in murine macrophages during activation by lipopolysaccharide (LPS) or poly (I¡ÃC) stimulation. -tissue_expression_down hsa-mir-134 "Carcinoma, Lung, Non-Small-Cell" 22937028 "High expression of miR-100 and low expression of miRNA-93, miRNA-134, miRNA-151 and miRNA-345 were associated with poor survival in both the training and validation cohort." -tissue_expression_down hsa-mir-151a "Carcinoma, Lung, Non-Small-Cell" 22937028 "High expression of miR-100 and low expression of miRNA-93, miRNA-134, miRNA-151 and miRNA-345 were associated with poor survival in both the training and validation cohort." -tissue_expression_down hsa-mir-151b "Carcinoma, Lung, Non-Small-Cell" 22937028 "High expression of miR-100 and low expression of miRNA-93, miRNA-134, miRNA-151 and miRNA-345 were associated with poor survival in both the training and validation cohort." -tissue_expression_down hsa-mir-345 "Carcinoma, Lung, Non-Small-Cell" 22937028 "High expression of miR-100 and low expression of miRNA-93, miRNA-134, miRNA-151 and miRNA-345 were associated with poor survival in both the training and validation cohort." -tissue_expression_down hsa-mir-93 "Carcinoma, Lung, Non-Small-Cell" 22937028 "High expression of miR-100 and low expression of miRNA-93, miRNA-134, miRNA-151 and miRNA-345 were associated with poor survival in both the training and validation cohort." -tissue_expression_down hsa-mir-193a Atrial Fibrillation 22944230 "MiR-155, miR-142-3p, miR-19b, miR-223, miR-146b-5p, miR-486-5p, miR-301b, miR-193b, miR-519b were found to be up-regulated by > 2 folds whereas miR-193a-5p was down-regulated in left atrial appendage (LAA) in patients with atrial fibrillation." -tissue_expression_down hsa-let-7g Breast Neoplasms 22964023 "We identified 11 dysregulated miRNAs in CAFs: three were up-regulated (miR-221-5p, miR-31-3p, miR-221-3p), while eight were down-regulated (miR-205, miR-200b, miR-200c, miR-141, miR-101,miR-342-3p, let-7g, miR-26b)" -tissue_expression_down hsa-mir-101 Breast Neoplasms 22964023 "We identified 11 dysregulated miRNAs in CAFs: three were up-regulated (miR-221-5p, miR-31-3p, miR-221-3p), while eight were down-regulated (miR-205, miR-200b, miR-200c, miR-141, miR-101,miR-342-3p, let-7g, miR-26b)" -tissue_expression_down hsa-mir-141 Breast Neoplasms 22964023 "We identified 11 dysregulated miRNAs in CAFs: three were up-regulated (miR-221-5p, miR-31-3p, miR-221-3p), while eight were down-regulated (miR-205, miR-200b, miR-200c, miR-141, miR-101,miR-342-3p, let-7g, miR-26b)" -tissue_expression_down hsa-mir-200b Breast Neoplasms 22964023 "We identified 11 dysregulated miRNAs in CAFs: three were up-regulated (miR-221-5p, miR-31-3p, miR-221-3p), while eight were down-regulated (miR-205, miR-200b, miR-200c, miR-141, miR-101,miR-342-3p, let-7g, miR-26b)" -tissue_expression_down hsa-mir-200c Breast Neoplasms 22964023 "We identified 11 dysregulated miRNAs in CAFs: three were up-regulated (miR-221-5p, miR-31-3p, miR-221-3p), while eight were down-regulated (miR-205, miR-200b, miR-200c, miR-141, miR-101,miR-342-3p, let-7g, miR-26b)" -tissue_expression_down hsa-mir-205 Breast Neoplasms 22964023 "We identified 11 dysregulated miRNAs in CAFs: three were up-regulated (miR-221-5p, miR-31-3p, miR-221-3p), while eight were down-regulated (miR-205, miR-200b, miR-200c, miR-141, miR-101,miR-342-3p, let-7g, miR-26b)" -tissue_expression_down hsa-mir-26b Breast Neoplasms 22964023 "We identified 11 dysregulated miRNAs in CAFs: three were up-regulated (miR-221-5p, miR-31-3p, miR-221-3p), while eight were down-regulated (miR-205, miR-200b, miR-200c, miR-141, miR-101,miR-342-3p, let-7g, miR-26b)" -tissue_expression_down hsa-mir-342 Breast Neoplasms 22964023 "We identified 11 dysregulated miRNAs in CAFs: three were up-regulated (miR-221-5p, miR-31-3p, miR-221-3p), while eight were down-regulated (miR-205, miR-200b, miR-200c, miR-141, miR-101,miR-342-3p, let-7g, miR-26b)" -tissue_expression_down hsa-mir-146a Tuberculosis 22964481 "we observed that miR-146a expression is also down-regulated in tuberculosis patients, both in PBMCs and PFMCs while miR-424 levels are elevated only in the peripheral compartments." -tissue_expression_down hsa-mir-146 Prion Diseases 22965126 "we show that exosomes released by prion-infected neuronal cells have increased let-7b, let-7i, miR-128a, miR-21, miR-222, miR-29b,miR-342-3p and miR-424 levels with decreased miR-146 a levels compared to non-infected exosomes." -tissue_expression_down hsa-mir-10a "Squamous Cell Carcinoma, Esophageal" 22966337 Down-regulation of microRNA 10a expression in esophageal squamous cell carcinoma cells. -tissue_expression_down hsa-mir-181a "Leukemia, Promyelocytic, Acute" 22967415 "The expression level of miR-15b, miR-16, miR-107, miR-223 and miR-342 in APL CR group were significantly upregulated compared with that of newly diagnosed APL groups (P < 0.05), while the expression level of miR-181a was significantly downregulated (P < 0.05)." -tissue_expression_down hsa-mir-10a "Carcinoma, Hepatocellular" 22976466 "Significant downregulation of miR-10a was observed in tumor compared with non-tumor tissues (0.50 vs. 1.73, p = 0.031)." -tissue_expression_down hsa-mir-143 Cervical Neoplasms 22997891 "The high expression of miR-21 in cervical cancer and Hela cell indicate that it may play a possible role of oncogenes, while miR-143 and miR-373 with low expression may play the role of tumor suppressor genes." -tissue_expression_down hsa-mir-373 Cervical Neoplasms 22997891 "The high expression of miR-21 in cervical cancer and Hela cell indicate that it may play a possible role of oncogenes, while miR-143 and miR-373 with low expression may play the role of tumor suppressor genes." -tissue_expression_down hsa-mir-100 Prostate Neoplasms 22999546 "miR-100 and miR-10a showed under expression and over expression, respectively, in low grade pTa tumors." -tissue_expression_down hsa-mir-140 "Squamous Cell Carcinoma, Skin or Unspecific" 23026055 "Non-stringent filtering with a non-adjusted p ¡Ü 0.01 revealed three up-regulated (hsa-miR-135b, hsa-miR-424 and hsa-miR-766) and six down-regulated (hsa-miR-30a*, hsa-miR-378, hsa-miR-145, hsa-miR-140-3p, hsa-miR-30a and hsa-miR-26a) miRNAs in cSCC" -tissue_expression_down hsa-mir-145 "Squamous Cell Carcinoma, Skin or Unspecific" 23026055 "Non-stringent filtering with a non-adjusted p ¡Ü 0.01 revealed three up-regulated (hsa-miR-135b, hsa-miR-424 and hsa-miR-766) and six down-regulated (hsa-miR-30a*, hsa-miR-378, hsa-miR-145, hsa-miR-140-3p, hsa-miR-30a and hsa-miR-26a) miRNAs in cSCC" -tissue_expression_down hsa-mir-26a "Squamous Cell Carcinoma, Skin or Unspecific" 23026055 "Non-stringent filtering with a non-adjusted p ¡Ü 0.01 revealed three up-regulated (hsa-miR-135b, hsa-miR-424 and hsa-miR-766) and six down-regulated (hsa-miR-30a*, hsa-miR-378, hsa-miR-145, hsa-miR-140-3p, hsa-miR-30a and hsa-miR-26a) miRNAs in cSCC" -tissue_expression_down hsa-mir-30a "Squamous Cell Carcinoma, Skin or Unspecific" 23026055 "Non-stringent filtering with a non-adjusted p ¡Ü 0.01 revealed three up-regulated (hsa-miR-135b, hsa-miR-424 and hsa-miR-766) and six down-regulated (hsa-miR-30a*, hsa-miR-378, hsa-miR-145, hsa-miR-140-3p, hsa-miR-30a and hsa-miR-26a) miRNAs in cSCC" -tissue_expression_down hsa-mir-378 "Squamous Cell Carcinoma, Skin or Unspecific" 23026055 "Non-stringent filtering with a non-adjusted p ¡Ü 0.01 revealed three up-regulated (hsa-miR-135b, hsa-miR-424 and hsa-miR-766) and six down-regulated (hsa-miR-30a*, hsa-miR-378, hsa-miR-145, hsa-miR-140-3p, hsa-miR-30a and hsa-miR-26a) miRNAs in cSCC" -tissue_expression_down hsa-mir-199a-1 Neoplasms [unspecific] 23060436 The microRNA miR-199a-5p down-regulation switches on wound angiogenesis by derepressing the v-ets erythroblastosis virus E26 oncogene homolog 1-matrix metalloproteinase-1 pathway -tissue_expression_down hsa-mir-199a-2 Neoplasms [unspecific] 23060436 The microRNA miR-199a-5p down-regulation switches on wound angiogenesis by derepressing the v-ets erythroblastosis virus E26 oncogene homolog 1-matrix metalloproteinase-1 pathway -tissue_expression_down hsa-mir-328 Glioblastoma 23077581 MiR-328 expression is decreased in high-grade gliomas and is associated with worse survival in primary glioblastoma -tissue_expression_down hsa-mir-1275 "Carcinoma, Hepatocellular" 23082062 "Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. " -tissue_expression_down hsa-mir-138 "Carcinoma, Hepatocellular" 23082062 "Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. " -tissue_expression_down hsa-mir-199a "Carcinoma, Hepatocellular" 23082062 "Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. " -tissue_expression_down hsa-mir-214 "Carcinoma, Hepatocellular" 23082062 "Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. " -tissue_expression_down hsa-mir-433 "Carcinoma, Hepatocellular" 23082062 "Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. " -tissue_expression_down hsa-mir-483 "Carcinoma, Hepatocellular" 23082062 "Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. " -tissue_expression_down hsa-mir-511 "Carcinoma, Hepatocellular" 23082062 "Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. " -tissue_expression_down hsa-mir-592 "Carcinoma, Hepatocellular" 23082062 "Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. " -tissue_expression_down hsa-mir-708 "Carcinoma, Hepatocellular" 23082062 "Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. " -tissue_expression_down hsa-mir-106b "Carcinoma, Hepatocellular" 23087084 miR-106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma -tissue_expression_down hsa-let-7c Esophageal Neoplasms 23092349 "A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. " -tissue_expression_down hsa-mir-100 Esophageal Neoplasms 23092349 "A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. " -tissue_expression_down hsa-mir-125b Esophageal Neoplasms 23092349 "A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. " -tissue_expression_down hsa-mir-145 Esophageal Neoplasms 23092349 "A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. " -tissue_expression_down hsa-mir-203 Esophageal Neoplasms 23092349 "A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. " -tissue_expression_down hsa-mir-205 Esophageal Neoplasms 23092349 "A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. " -tissue_expression_down hsa-mir-27b Esophageal Neoplasms 23092349 "A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. " -tissue_expression_down hsa-mir-375 Esophageal Neoplasms 23092349 "A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. " -tissue_expression_down hsa-mir-375 Glioma 23103713 Correlation of microRNA-375 downregulation with unfavorable clinical outcome of patients with glioma -tissue_expression_down hsa-mir-145 Meningioma 23108408 miRNA-145 is downregulated in atypical and anaplastic meningiomas and negatively regulates motility and proliferation of meningioma cells -tissue_expression_down hsa-mir-24-1 Melanoma 23111773 "In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated." -tissue_expression_down hsa-mir-26a Melanoma 23111773 "In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated." -tissue_expression_down hsa-mir-4291 Melanoma 23111773 "In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated." -tissue_expression_down hsa-mir-4317 Melanoma 23111773 "In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated." -tissue_expression_down hsa-mir-4324 Melanoma 23111773 "In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated." -tissue_expression_down hsa-mir-204 Pulmonary Hypertension 23114789 "MEX suppressed the hypoxic activation of signal transducer and activator of transcription 3 (STAT3) and the upregulation of the miR-17 superfamily of microRNA clusters, whereas it increased lung levels of miR-204, a key microRNA, the expression of which is decreased in human pulmonary hypertension." -tissue_expression_down hsa-mir-10b Breast Neoplasms 23125021 "miR-10b*, a master inhibitor of the cell cycle, is down-regulated in human breast tumours" -tissue_expression_down hsa-mir-495 Leukemia 23132946 MiR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia -tissue_expression_down hsa-mir-224 Prostate Neoplasms 23136246 Downregulation and Prognostic Performance of MicroRNA 224 Expression in Prostate Cancer -tissue_expression_down hsa-mir-383 Medulloblastoma 23157748 "Compared with normal brain tissue, decreased expression of miR-383 but elevated expression of PRDX3 are medulloblastoma tumour and Daoy cell lines" -tissue_expression_down hsa-mir-1 Bladder Neoplasms 23169479 "three miRNAs were upregulated (miR-200b, miR-182 and miR-138) and the other 10 miRNAs were downregulated (miR-1, miR-133a, miR-133b, miR-145, miR-143, miR-204, miR-921, miR-1281, miR-199a and miR-199b)" -tissue_expression_down hsa-mir-1281 Bladder Neoplasms 23169479 "three miRNAs were upregulated (miR-200b, miR-182 and miR-138) and the other 10 miRNAs were downregulated (miR-1, miR-133a, miR-133b, miR-145, miR-143, miR-204, miR-921, miR-1281, miR-199a and miR-199b)" -tissue_expression_down hsa-mir-133a Bladder Neoplasms 23169479 "three miRNAs were upregulated (miR-200b, miR-182 and miR-138) and the other 10 miRNAs were downregulated (miR-1, miR-133a, miR-133b, miR-145, miR-143, miR-204, miR-921, miR-1281, miR-199a and miR-199b)" -tissue_expression_down hsa-mir-133b Bladder Neoplasms 23169479 "three miRNAs were upregulated (miR-200b, miR-182 and miR-138) and the other 10 miRNAs were downregulated (miR-1, miR-133a, miR-133b, miR-145, miR-143, miR-204, miR-921, miR-1281, miR-199a and miR-199b)" -tissue_expression_down hsa-mir-143 Bladder Neoplasms 23169479 "three miRNAs were upregulated (miR-200b, miR-182 and miR-138) and the other 10 miRNAs were downregulated (miR-1, miR-133a, miR-133b, miR-145, miR-143, miR-204, miR-921, miR-1281, miR-199a and miR-199b)" -tissue_expression_down hsa-mir-145 Bladder Neoplasms 23169479 "three miRNAs were upregulated (miR-200b, miR-182 and miR-138) and the other 10 miRNAs were downregulated (miR-1, miR-133a, miR-133b, miR-145, miR-143, miR-204, miR-921, miR-1281, miR-199a and miR-199b)" -tissue_expression_down hsa-mir-199a Bladder Neoplasms 23169479 "three miRNAs were upregulated (miR-200b, miR-182 and miR-138) and the other 10 miRNAs were downregulated (miR-1, miR-133a, miR-133b, miR-145, miR-143, miR-204, miR-921, miR-1281, miR-199a and miR-199b)" -tissue_expression_down hsa-mir-199b Bladder Neoplasms 23169479 "three miRNAs were upregulated (miR-200b, miR-182 and miR-138) and the other 10 miRNAs were downregulated (miR-1, miR-133a, miR-133b, miR-145, miR-143, miR-204, miR-921, miR-1281, miR-199a and miR-199b)" -tissue_expression_down hsa-mir-204 Bladder Neoplasms 23169479 "three miRNAs were upregulated (miR-200b, miR-182 and miR-138) and the other 10 miRNAs were downregulated (miR-1, miR-133a, miR-133b, miR-145, miR-143, miR-204, miR-921, miR-1281, miR-199a and miR-199b)" -tissue_expression_down hsa-mir-921 Bladder Neoplasms 23169479 "three miRNAs were upregulated (miR-200b, miR-182 and miR-138) and the other 10 miRNAs were downregulated (miR-1, miR-133a, miR-133b, miR-145, miR-143, miR-204, miR-921, miR-1281, miR-199a and miR-199b)" -tissue_expression_down hsa-mir-192 Asthma 23170939 MiR-192 was technically validated using real-time reverse transcription-quantitative polymerase chain reaction (RT-qPCR) showing that the level in asthmatics (pre-challenge) was significantly lower than HCs and that post-challenge was significantly lower than pre-challenge. -tissue_expression_down hsa-mir-214 Ovarian Neoplasms 23171795 "We found that in ovarian CAFs, miR-31 and miR-214 were downregulated, whereas miR-155 was upregulated when compared with normal or tumor-adjacent fibroblasts." -tissue_expression_down hsa-mir-31 Ovarian Neoplasms 23171795 "We found that in ovarian CAFs, miR-31 and miR-214 were downregulated, whereas miR-155 was upregulated when compared with normal or tumor-adjacent fibroblasts." -tissue_expression_down hsa-mir-199a-1 "Carcinoma, Renal Cell" 23174576 "A decreased expression of miR-199a is significantly correlated with a higher tumor stage, a greater likeliness of tumor recurrence, and a poorer prognosis in RCC patients" -tissue_expression_down hsa-mir-199a-2 "Carcinoma, Renal Cell" 23174576 "A decreased expression of miR-199a is significantly correlated with a higher tumor stage, a greater likeliness of tumor recurrence, and a poorer prognosis in RCC patients" -tissue_expression_down hsa-mir-216a Pancreatic Neoplasms 23174591 The down-regulated expression of miR-216a in pancreatic cancer suggests the involvement of miR-216a in the tumorigenesis and development of pancreatic cancer -tissue_expression_down hsa-mir-106a Colorectal Carcinoma 23178825 miR-106a overexpression and pRB downregulation in sporadic colorectal cancer -tissue_expression_down hsa-mir-153-1 Neoplasms [unspecific] 23188671 Downregulation of miR-153 contributes to epithelial-mesenchymal transition and tumor metastasis in human epithelial cancer -tissue_expression_down hsa-mir-153-2 Neoplasms [unspecific] 23188671 Downregulation of miR-153 contributes to epithelial-mesenchymal transition and tumor metastasis in human epithelial cancer -tissue_expression_down hsa-mir-26a-1 Melanoma 23190898 MicroRNA-26a Is Strongly Downregulated in Melanoma and Induces Cell Death through Repression of Silencer of Death Domains -tissue_expression_down hsa-mir-26a-2 Melanoma 23190898 MicroRNA-26a Is Strongly Downregulated in Melanoma and Induces Cell Death through Repression of Silencer of Death Domains -tissue_expression_down hsa-mir-421 "Squamous Cell Carcinoma, Skin or Unspecific" 23199656 Aberrant overexpression of miR-421 downregulates ATM and leads to a pronounced DSB repair defect and clinical hypersensitivity in SKX squamous cell carcinoma -tissue_expression_down hsa-mir-186 Lung Neoplasms 23204228 "miR-186 Downregulation Correlates with Poor Survival in Lung Adenocarcinoma,Where It Interferes with Cell-Cycle Regulation" -tissue_expression_down hsa-mir-1228 "Carcinoma, Hepatocellular" 23205106 "The following miRNAs were downregulated in the tumor and non-tumor tissues, and thus could serve as novel biomarkers for chronic liver diseases: miR-18b*, miR-296-5p, miR-557, miR-581, miR-625*, miR-1228, miR-1249 and miR-2116*. Similarly, miR-129*, miR-146b-3p and miR-448 are novel candidates for HCC biomarkers regardless of virus infection." -tissue_expression_down hsa-mir-1249 "Carcinoma, Hepatocellular" 23205106 "The following miRNAs were downregulated in the tumor and non-tumor tissues, and thus could serve as novel biomarkers for chronic liver diseases: miR-18b*, miR-296-5p, miR-557, miR-581, miR-625*, miR-1228, miR-1249 and miR-2116*. Similarly, miR-129*, miR-146b-3p and miR-448 are novel candidates for HCC biomarkers regardless of virus infection." -tissue_expression_down hsa-mir-129 "Carcinoma, Hepatocellular" 23205106 "The following miRNAs were downregulated in the tumor and non-tumor tissues, and thus could serve as novel biomarkers for chronic liver diseases: miR-18b*, miR-296-5p, miR-557, miR-581, miR-625*, miR-1228, miR-1249 and miR-2116*. Similarly, miR-129*, miR-146b-3p and miR-448 are novel candidates for HCC biomarkers regardless of virus infection." -tissue_expression_down hsa-mir-146 "Carcinoma, Hepatocellular" 23205106 "The following miRNAs were downregulated in the tumor and non-tumor tissues, and thus could serve as novel biomarkers for chronic liver diseases: miR-18b*, miR-296-5p, miR-557, miR-581, miR-625*, miR-1228, miR-1249 and miR-2116*. Similarly, miR-129*, miR-146b-3p and miR-448 are novel candidates for HCC biomarkers regardless of virus infection." -tissue_expression_down hsa-mir-18b "Carcinoma, Hepatocellular" 23205106 "The following miRNAs were downregulated in the tumor and non-tumor tissues, and thus could serve as novel biomarkers for chronic liver diseases: miR-18b*, miR-296-5p, miR-557, miR-581, miR-625*, miR-1228, miR-1249 and miR-2116*. Similarly, miR-129*, miR-146b-3p and miR-448 are novel candidates for HCC biomarkers regardless of virus infection." -tissue_expression_down hsa-mir-2116 "Carcinoma, Hepatocellular" 23205106 "The following miRNAs were downregulated in the tumor and non-tumor tissues, and thus could serve as novel biomarkers for chronic liver diseases: miR-18b*, miR-296-5p, miR-557, miR-581, miR-625*, miR-1228, miR-1249 and miR-2116*. Similarly, miR-129*, miR-146b-3p and miR-448 are novel candidates for HCC biomarkers regardless of virus infection." -tissue_expression_down hsa-mir-296 "Carcinoma, Hepatocellular" 23205106 "The following miRNAs were downregulated in the tumor and non-tumor tissues, and thus could serve as novel biomarkers for chronic liver diseases: miR-18b*, miR-296-5p, miR-557, miR-581, miR-625*, miR-1228, miR-1249 and miR-2116*. Similarly, miR-129*, miR-146b-3p and miR-448 are novel candidates for HCC biomarkers regardless of virus infection." -tissue_expression_down hsa-mir-448 "Carcinoma, Hepatocellular" 23205106 "The following miRNAs were downregulated in the tumor and non-tumor tissues, and thus could serve as novel biomarkers for chronic liver diseases: miR-18b*, miR-296-5p, miR-557, miR-581, miR-625*, miR-1228, miR-1249 and miR-2116*. Similarly, miR-129*, miR-146b-3p and miR-448 are novel candidates for HCC biomarkers regardless of virus infection." -tissue_expression_down hsa-mir-557 "Carcinoma, Hepatocellular" 23205106 "The following miRNAs were downregulated in the tumor and non-tumor tissues, and thus could serve as novel biomarkers for chronic liver diseases: miR-18b*, miR-296-5p, miR-557, miR-581, miR-625*, miR-1228, miR-1249 and miR-2116*. Similarly, miR-129*, miR-146b-3p and miR-448 are novel candidates for HCC biomarkers regardless of virus infection." -tissue_expression_down hsa-mir-581 "Carcinoma, Hepatocellular" 23205106 "The following miRNAs were downregulated in the tumor and non-tumor tissues, and thus could serve as novel biomarkers for chronic liver diseases: miR-18b*, miR-296-5p, miR-557, miR-581, miR-625*, miR-1228, miR-1249 and miR-2116*. Similarly, miR-129*, miR-146b-3p and miR-448 are novel candidates for HCC biomarkers regardless of virus infection." -tissue_expression_down hsa-mir-625 "Carcinoma, Hepatocellular" 23205106 "The following miRNAs were downregulated in the tumor and non-tumor tissues, and thus could serve as novel biomarkers for chronic liver diseases: miR-18b*, miR-296-5p, miR-557, miR-581, miR-625*, miR-1228, miR-1249 and miR-2116*. Similarly, miR-129*, miR-146b-3p and miR-448 are novel candidates for HCC biomarkers regardless of virus infection." -tissue_expression_down hsa-mir-544a Glioma 23205130 "Downregulation of miR-544 in tissue, but not in serum, is a novel biomarker of malignant transformation in glioma" -tissue_expression_down hsa-mir-544b Glioma 23205130 "Downregulation of miR-544 in tissue, but not in serum, is a novel biomarker of malignant transformation in glioma" -tissue_expression_down hsa-mir-141 "Carcinoma, Renal Cell" 23206420 A possible role for micro-RNA 141 down-regulation in sunitinib resistant metastatic clear cell renal cell carcinoma through induction of epithelial-to-mesenchymal transition and hypoxia resistance -tissue_expression_down hsa-mir-26b "Carcinoma, Lung, Non-Small-Cell" 23207443 SQCC was distinguished from normal tissue and ADC by high-level miR-205 expression and decreased miR-26b. -tissue_expression_down hsa-mir-107 Glioma 23220650 P53-induced microRNA-107 inhibits proliferation of glioma cells and down-regulates the expression of CDK6 and Notch-2 -tissue_expression_down hsa-mir-150 "Carcinoma, Lung, Non-Small-Cell" 23228962 Expression of miR-150 and miR-3940-5p is reduced in non-small cell lung carcinoma and correlates with clinicopathological features -tissue_expression_down hsa-mir-3940 "Carcinoma, Lung, Non-Small-Cell" 23228962 Expression of miR-150 and miR-3940-5p is reduced in non-small cell lung carcinoma and correlates with clinicopathological features -tissue_expression_down hsa-mir-214 Ovarian Neoplasms 23230184 They found that decreased miR-31 and miR-214 and increased miR-155 expression can reprogram normal fibroblasts into tumor-promoting cancer-associated fibroblasts. -tissue_expression_down hsa-mir-31 Ovarian Neoplasms 23230184 They found that decreased miR-31 and miR-214 and increased miR-155 expression can reprogram normal fibroblasts into tumor-promoting cancer-associated fibroblasts. -tissue_expression_down hsa-mir-326 Glioma 23292865 "Down-regulation of miR-326 may have potential value for predicting clinical outcomes in glioma patients with high pathological grades, suggesting that miR-326 is an important candidate tumor suppressor, and its down-regulated expression may contribute to glioma progression" -tissue_expression_down hsa-mir-9 Waldenstrom Macroglobulinemia 23301642 The most important changes of microRNA are increased expression of miR-155 and decreased expression of miR-9*. -tissue_expression_down hsa-mir-125b-1 Systemic Lupus Erythematosus 23305626 "Further analysis showed that the down-regulation of miR-125b, mainly in T cells, was negatively correlated with lupus nephritis" -tissue_expression_down hsa-mir-125b-2 Systemic Lupus Erythematosus 23305626 "Further analysis showed that the down-regulation of miR-125b, mainly in T cells, was negatively correlated with lupus nephritis" -tissue_expression_down hsa-mir-30c-1 Neoplasms [unspecific] 23318178 Sulfuretin-induced miR-30C selectively downregulates cyclin D1 and D2 and triggers cell death in human cancer cell lines -tissue_expression_down hsa-mir-30c-2 Neoplasms [unspecific] 23318178 Sulfuretin-induced miR-30C selectively downregulates cyclin D1 and D2 and triggers cell death in human cancer cell lines -tissue_expression_down hsa-mir-150 Myocardial Infarction 23326587 "Adenosine increases the migration of EPC. The mechanism involves A(2B) receptor activation, decreased expression of miR-150 and increased expression of CXCR4." -tissue_expression_down hsa-mir-214 Urinary Bladder Cancer 23337879 MiR-214 reduces cell survival and enhances cisplatin-induced cytotoxicity via down-regulation of Bcl2l2 in cervical cancer cells -tissue_expression_down hsa-let-7 Pancreatic Neoplasms 23338123 "The BxPC-3-LN cells expressed lower levels of let-7, miR-34, miR-107, miR-125, miR-128, miR-130, miR-132 and miR-141 than the parental BxPC-3 cells detected by microRNA PCR array, which were reported to have close relation to stem cell factors." -tissue_expression_down hsa-mir-107 Pancreatic Neoplasms 23338123 "The BxPC-3-LN cells expressed lower levels of let-7, miR-34, miR-107, miR-125, miR-128, miR-130, miR-132 and miR-141 than the parental BxPC-3 cells detected by microRNA PCR array, which were reported to have close relation to stem cell factors." -tissue_expression_down hsa-mir-125 Pancreatic Neoplasms 23338123 "The BxPC-3-LN cells expressed lower levels of let-7, miR-34, miR-107, miR-125, miR-128, miR-130, miR-132 and miR-141 than the parental BxPC-3 cells detected by microRNA PCR array, which were reported to have close relation to stem cell factors." -tissue_expression_down hsa-mir-128 Pancreatic Neoplasms 23338123 "The BxPC-3-LN cells expressed lower levels of let-7, miR-34, miR-107, miR-125, miR-128, miR-130, miR-132 and miR-141 than the parental BxPC-3 cells detected by microRNA PCR array, which were reported to have close relation to stem cell factors." -tissue_expression_down hsa-mir-130 Pancreatic Neoplasms 23338123 "The BxPC-3-LN cells expressed lower levels of let-7, miR-34, miR-107, miR-125, miR-128, miR-130, miR-132 and miR-141 than the parental BxPC-3 cells detected by microRNA PCR array, which were reported to have close relation to stem cell factors." -tissue_expression_down hsa-mir-132 Pancreatic Neoplasms 23338123 "The BxPC-3-LN cells expressed lower levels of let-7, miR-34, miR-107, miR-125, miR-128, miR-130, miR-132 and miR-141 than the parental BxPC-3 cells detected by microRNA PCR array, which were reported to have close relation to stem cell factors." -tissue_expression_down hsa-mir-141 Pancreatic Neoplasms 23338123 "The BxPC-3-LN cells expressed lower levels of let-7, miR-34, miR-107, miR-125, miR-128, miR-130, miR-132 and miR-141 than the parental BxPC-3 cells detected by microRNA PCR array, which were reported to have close relation to stem cell factors." -tissue_expression_down hsa-mir-34 Pancreatic Neoplasms 23338123 "The BxPC-3-LN cells expressed lower levels of let-7, miR-34, miR-107, miR-125, miR-128, miR-130, miR-132 and miR-141 than the parental BxPC-3 cells detected by microRNA PCR array, which were reported to have close relation to stem cell factors." -tissue_expression_down hsa-mir-93 Colorectal Carcinoma 23354160 "the downregulation of miR-93 was significantly correlated with unfavorable clinicopathologic features and short overall survival in patients with colon cancer, suggesting that decreased expression of miR-93 be used as a novel prognostic factor for this disease" -tissue_expression_down hsa-mir-34a Colorectal Carcinoma 23355243 The down-regulated expression of miR-34a in colorectal cancer patients is associated with recurrence after radical operation -tissue_expression_down hsa-mir-132 Breast Neoplasms 23399321 MicroRNA-132 is frequently down-regulated in ductal carcinoma in situ (DCIS) of breast and acts as a tumor suppressor by inhibiting cell proliferation -tissue_expression_down hsa-mir-31 Urinary Bladder Cancer 23408039 Decreased expression of microRNA-31 associates with aggressive tumor progression and poor prognosis in patients with bladder cancer -tissue_expression_down hsa-mir-130a Chronic Hepatitis C 23418453 "Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-¦Á treatment (p<0.01)" -tissue_expression_down hsa-mir-192 Chronic Hepatitis C 23418453 "Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-¦Á treatment (p<0.01)" -tissue_expression_down hsa-mir-301 Chronic Hepatitis C 23418453 "Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-¦Á treatment (p<0.01)" -tissue_expression_down hsa-mir-30b Chronic Hepatitis C 23418453 "Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-¦Á treatment (p<0.01)" -tissue_expression_down hsa-mir-30c Chronic Hepatitis C 23418453 "Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-¦Á treatment (p<0.01)" -tissue_expression_down hsa-mir-324 Chronic Hepatitis C 23418453 "Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-¦Á treatment (p<0.01)" -tissue_expression_down hsa-mir-565 Chronic Hepatitis C 23418453 "Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-¦Á treatment (p<0.01)" -tissue_expression_down hsa-mir-17 Colon Neoplasms 23436804 "We detect and confirm 27 miRNAs to be significantly changed following ER¦Â expression in SW480 colon cancer cells. Among these, the oncogenic miR-17-92 cluster and miR-200a/b are strongly downregulated. Using target prediction and anticorrelation to gene expression data followed by focused mechanistic studies, we demonstrate that repression of miR-17 is a secondary event following ER¦Â's downregulatory effect on MYC. " -tissue_expression_down hsa-mir-18 Colon Neoplasms 23436804 "We detect and confirm 27 miRNAs to be significantly changed following ER¦Â expression in SW480 colon cancer cells. Among these, the oncogenic miR-17-92 cluster and miR-200a/b are strongly downregulated. Using target prediction and anticorrelation to gene expression data followed by focused mechanistic studies, we demonstrate that repression of miR-17 is a secondary event following ER¦Â's downregulatory effect on MYC. " -tissue_expression_down hsa-mir-19a Colon Neoplasms 23436804 "We detect and confirm 27 miRNAs to be significantly changed following ER¦Â expression in SW480 colon cancer cells. Among these, the oncogenic miR-17-92 cluster and miR-200a/b are strongly downregulated. Using target prediction and anticorrelation to gene expression data followed by focused mechanistic studies, we demonstrate that repression of miR-17 is a secondary event following ER¦Â's downregulatory effect on MYC. " -tissue_expression_down hsa-mir-19b-1 Colon Neoplasms 23436804 "We detect and confirm 27 miRNAs to be significantly changed following ER¦Â expression in SW480 colon cancer cells. Among these, the oncogenic miR-17-92 cluster and miR-200a/b are strongly downregulated. Using target prediction and anticorrelation to gene expression data followed by focused mechanistic studies, we demonstrate that repression of miR-17 is a secondary event following ER¦Â's downregulatory effect on MYC. " -tissue_expression_down hsa-mir-200a Colon Neoplasms 23436804 "We detect and confirm 27 miRNAs to be significantly changed following ER¦Â expression in SW480 colon cancer cells. Among these, the oncogenic miR-17-92 cluster and miR-200a/b are strongly downregulated. Using target prediction and anticorrelation to gene expression data followed by focused mechanistic studies, we demonstrate that repression of miR-17 is a secondary event following ER¦Â's downregulatory effect on MYC. " -tissue_expression_down hsa-mir-200b Colon Neoplasms 23436804 "We detect and confirm 27 miRNAs to be significantly changed following ER¦Â expression in SW480 colon cancer cells. Among these, the oncogenic miR-17-92 cluster and miR-200a/b are strongly downregulated. Using target prediction and anticorrelation to gene expression data followed by focused mechanistic studies, we demonstrate that repression of miR-17 is a secondary event following ER¦Â's downregulatory effect on MYC. " -tissue_expression_down hsa-mir-20a Colon Neoplasms 23436804 "We detect and confirm 27 miRNAs to be significantly changed following ER¦Â expression in SW480 colon cancer cells. Among these, the oncogenic miR-17-92 cluster and miR-200a/b are strongly downregulated. Using target prediction and anticorrelation to gene expression data followed by focused mechanistic studies, we demonstrate that repression of miR-17 is a secondary event following ER¦Â's downregulatory effect on MYC. " -tissue_expression_down hsa-mir-92-1 Colon Neoplasms 23436804 "We detect and confirm 27 miRNAs to be significantly changed following ER¦Â expression in SW480 colon cancer cells. Among these, the oncogenic miR-17-92 cluster and miR-200a/b are strongly downregulated. Using target prediction and anticorrelation to gene expression data followed by focused mechanistic studies, we demonstrate that repression of miR-17 is a secondary event following ER¦Â's downregulatory effect on MYC. " -tissue_expression_down hsa-mir-200a Gastrointestinal Neoplasms 23456798 It was noteworthy that miR-200a was significantly down-regulated in gastric adenocarcinoma samples (P = .04) but was up-regulated in esophageal adenocarcinoma samples (P = .001). -tissue_expression_down hsa-mir-375 "Adenocarcinoma, Gastric" 23461060 "In our study, the expression of a subset of microRNAs was altered in distal gastric adenocarcinoma compared to normal tissue, miR-375 was significantly downregulated in distal gastric adenocarcinoma tissues, to a level that was significantly lower than cardia adenocarcinoma (p < 0.05)." -tissue_expression_down hsa-mir-206 Breast Neoplasms 23466356 miR-206 is down-regulated in breast cancer and inhibits cell proliferation through the up-regulation of cyclinD2 -tissue_expression_down hsa-mir-371 "Carcinoma, Hepatocellular" 23466643 miR-371-5p down-regulates pre mRNA processing factor 4 homolog B (PRPF4B) and facilitates the G1/S transition in human hepatocellular carcinoma cells -tissue_expression_down hsa-mir-135b Esophageal Neoplasms 23477513 patients with either decreased miR-135b or increased miR-145 expression in cancer tissue had improved disease-free survival -tissue_expression_down hsa-mir-146a Ischemia-Reperfusion Injury 23498784 Down-regulation of microRNA-146a in the early stage of liver ischemia-reperfusion injury. -tissue_expression_down hsa-mir-302b "Adenocarcinoma, Gastric" 23508453 "Down-regulation of miR-302b, an ESC-specific microRNA, in Gastric Adenocarcinoma." -tissue_expression_down hsa-let-7i Inflammation 23509825 This let-7i downregulation in dendritic cells constitutes a novel feature of the modulatory activity that helminth-derived antigens exert on their host. -tissue_expression_down hsa-mir-145 "Squamous Cell Carcinoma, Oral" 23548968 Downregulation of miR-145 Expression in Oral Squamous Cell Carcinomas and Its Clinical Significance -tissue_expression_down hsa-mir-27b Colorectal Carcinoma 23593282 "we demonstrated that miR-27b expression is decreased in most CRC tissues and determined that overexpression of miR-27b represses CRC cell proliferation, colony formation and tumor growth in vitro and in vivo." -tissue_expression_down hsa-mir-223 Osteosarcoma 23601845 we found that miRNA-223 was downregulated in both osteosarcoma patients' tumor tissues and osteosarcoma cell lines. -tissue_expression_down hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 23615967 "Significant upregulation of miR-150, miR-29c, miR-143 and miR-223 and downregulation of miR-15a was found in mutated versus unmutated CLL, with miR-15a showing the highest fold difference." -tissue_expression_down hsa-mir-200a Breast Neoplasms 23626803 Reduced expression of miR-200 family members contributes to antiestrogen resistance in LY2 human breast cancer cells. -tissue_expression_down hsa-mir-200b Breast Neoplasms 23626803 Reduced expression of miR-200 family members contributes to antiestrogen resistance in LY2 human breast cancer cells. -tissue_expression_down hsa-mir-200c Breast Neoplasms 23626803 Reduced expression of miR-200 family members contributes to antiestrogen resistance in LY2 human breast cancer cells. -tissue_expression_down hsa-mir-205 Melanoma 23629002 microRNA (miR)-205 is downregulated and acts as a tumor suppressor in human melanoma cells. -tissue_expression_down hsa-let-7e Allergic Rhinitis 23704072 "Subjects with current allergic rhinitis symptoms had increased levels of miR-155, miR-205, and miR-498, but reduced levels of let-7e." -tissue_expression_down hsa-mir-125b Bladder Neoplasms 23712207 "miRNAs downregulated in bladder cancer, such as miR-145, miR-143 and miR125b, are known to be tumour suppressors" -tissue_expression_down hsa-mir-143 Bladder Neoplasms 23712207 "miRNAs downregulated in bladder cancer, such as miR-145, miR-143 and miR125b, are known to be tumour suppressors" -tissue_expression_down hsa-mir-145 Bladder Neoplasms 23712207 "miRNAs downregulated in bladder cancer, such as miR-145, miR-143 and miR125b, are known to be tumour suppressors" -tissue_expression_down hsa-mir-1246 Pulmonary Hypertension 23717609 "We identified several novel downregulated miRNAs (miR-451, miR-1246) and upregulated miRNAs (miR-23b, miR-130a and miR-191) in the circulation of PH subjects." -tissue_expression_down hsa-mir-451 Pulmonary Hypertension 23717609 "We identified several novel downregulated miRNAs (miR-451, miR-1246) and upregulated miRNAs (miR-23b, miR-130a and miR-191) in the circulation of PH subjects." -tissue_expression_down hsa-mir-122 "Carcinoma, Hepatocellular" 23727126 "miR-122, a liver-specific tumor suppressor microRNA, is frequently down-regulated in hepatocellular carcinoma (HCC)" -tissue_expression_down hsa-mir-146a Osteoarthritis 23744481 The downregulation of miR-146a and/or the miR-183 cluster in the central compartments (DRG and spinal cord) are closely associated with the upregulation of inflammatory pain mediators. -tissue_expression_down hsa-mir-183 Osteoarthritis 23744481 The downregulation of miR-146a and/or the miR-183 cluster in the central compartments (DRG and spinal cord) are closely associated with the upregulation of inflammatory pain mediators. -tissue_expression_down hsa-mir-206 Gastric Neoplasms 23751352 Downregulation of microRNA-206 is a potent prognostic marker for patients with gastric cancer. -tissue_expression_down hsa-mir-1-1 Lung Neoplasms 23761296 Sustainable downregulation in the lung tissues in lung carcinogenesis induced by urethane. -tissue_expression_down hsa-mir-1-2 Lung Neoplasms 23761296 Sustainable downregulation in the lung tissues in lung carcinogenesis induced by urethane. -tissue_expression_down hsa-mir-126 Esophageal Neoplasms 23761828 downregulated -tissue_expression_down hsa-mir-223 Esophageal Neoplasms 23761828 downregulated -tissue_expression_down hsa-mir-30b Esophageal Neoplasms 23761828 downregulated -tissue_expression_down hsa-mir-454 Esophageal Neoplasms 23761828 downregulated -tissue_expression_down hsa-mir-486 Esophageal Neoplasms 23761828 downregulated -tissue_expression_down hsa-mir-574 Esophageal Neoplasms 23761828 miR-574-3p:downregulated -tissue_expression_down hsa-mir-22 "Carcinoma, Hepatocellular" 23766411 "miR-22 is downregulated in HCC and its expression is associated with the differentiation, metastasis and prognosis of the carcinoma. Ezrin is a potential regulatory protein of miR-22." -tissue_expression_down hsa-mir-21 Colorectal Carcinoma 23773491 "In Taiwan, downregulation of the APC gene in CRC correlated with gene mutation and mir-21 upregulation. APC mutation and mir-21 expression could be used to predict the clinical outcome of CRC, especially in patients with advanced disease." -tissue_expression_down hsa-mir-17 "Squamous Cell Carcinoma, Oral" 23780339 "miR-17-5p is induced in irradiated OC3 cells and it downregulates p21 protein expression, contributing to the radioresistance of OC3 cells." -tissue_expression_down hsa-mir-205 Hereditary Hemorrhagic Telangiectasia 23800974 MiR-205 is downregulated in hereditary hemorrhagic telangiectasia and impairs TGF-beta signaling pathways in endothelial cells. -tissue_expression_down hsa-mir-27a Pancreatic Neoplasms 23803693 "in Panc1 cells metformin decreased microRNA-27a and induced the Sp repressor, ZBTB10, and disruption of miR-27a:ZBTB10 by metformin was phosphatase dependent." -tissue_expression_down hsa-mir-34c Lung Neoplasms 23805317 MiR-34a and miR-34c were downregulated in lung tumors compared to normal tissues. -tissue_expression_down hsa-mir-124 Glioblastoma 23817964 MiR-124 inhibits the growth of glioblastoma through the downregulation of SOS1. -tissue_expression_down hsa-mir-181b "Carcinoma, Lung, Non-Small-Cell" 23827213 Down-regulation of microRNA-181b is a potential prognostic marker of non-small cell lung cancer. -tissue_expression_down hsa-mir-19a Breast Neoplasms 23831570 MicroRNA-19a-3p inhibits breast cancer progression and metastasis by inducing macrophage polarization through downregulated expression of Fra-1 proto-oncogene. -tissue_expression_down hsa-mir-223 Pancreatic Neoplasms 23834147 Genistein down-regulates miR-223 expression in pancreatic cancer cells. -tissue_expression_down hsa-mir-451 Colorectal Carcinoma 23886157 MicroRNA-451 inhibits growth of human colorectal carcinoma cells via downregulation of Pi3k/Akt pathway. -tissue_expression_down hsa-mir-21 "Carcinoma, Colon" 23894315 Difluorinated-curcumin (CDF) restores PTEN expression in colon cancer cells by down-regulating miR-21. -tissue_expression_down hsa-mir-187 "Carcinoma, Renal Cell, Clear-Cell" 23916610 "MicroRNA-187, down-regulated in clear cell renal cell carcinoma and associated with lower survival, inhibits cell growth and migration though targeting B7-H3." -tissue_expression_down hsa-mir-223 "Carcinoma, Hepatocellular" 23925649 MiR-223 modulates multidrug resistance via downregulation of ABCB1 in hepatocellular carcinoma cells. -tissue_expression_down hsa-mir-34a Prostate Neoplasms 23936419 Our results indicated that genistein inhibited PCa cell growth through down-regulation of oncogenic HOTAIR that is also targeted by tumor suppressor miR-34a. These findings enhance understanding of how genistein regulates lncRNA HOTAIR and miR-34a in PCa. -tissue_expression_down hsa-mir-26b Breast Neoplasms 23939832 MiR-26b is down-regulated in carcinoma-associated fibroblasts from ER-positive breast cancers leading to enhanced cell migration and invasion. -tissue_expression_down hsa-let-7i "Carcinoma, Bladder" 23946872 "Within this group, let-7b and let-7i exhibited decreased expression, while miR-1290 and miR-138 displayed increased expression levels in gemcitabine-resistant cells." -tissue_expression_down hsa-mir-218 Medulloblastoma 23970061 miR-218 is downregulated and directly targets SH3GL1 in childhood medulloblastoma. -tissue_expression_down hsa-mir-205 Prostate Neoplasms 23974361 miR-205 is frequently downregulated in prostate cancer and acts as a tumor suppressor by inhibiting tumor growth. -tissue_expression_down hsa-mir-15 "Leukemia, Lymphocytic, Chronic, B-Cell" 23974981 Defective DROSHA processing contributes to downregulation of MiR-15/-16 in chronic lymphocytic leukemia. -tissue_expression_down hsa-mir-16 "Leukemia, Lymphocytic, Chronic, B-Cell" 23974981 Defective DROSHA processing contributes to downregulation of MiR-15/-16 in chronic lymphocytic leukemia. -tissue_expression_down hsa-mir-145 Inflammation 23980205 "We demonstrate that miR-145, downregulated by IFN-I,targets histone deacetylase 11 to promote innate IL-10 expression in macrophages.Our findings suggest a new IFN-I-mediated negative feedback loop in the fine-tuning of innate IL-10 production that creates precise coordination of innate immune responses." -tissue_expression_down hsa-mir-203 "Carcinoma, Esophageal" 24001611 MiR-203 suppresses tumor growth and invasion and down-regulates MiR-21 expression through repressing Ran in esophageal cancer. -tissue_expression_down hsa-mir-21 "Carcinoma, Esophageal" 24001611 MiR-203 suppresses tumor growth and invasion and down-regulates MiR-21 expression through repressing Ran in esophageal cancer. -tissue_expression_down hsa-mir-137 Melanoma 24001901 "miR-34a, miR-137 and miR-182 all had lower expression levels in uveal melanoma cell lines, compared with normal cells" -tissue_expression_down hsa-mir-182 Melanoma 24001901 "miR-34a, miR-137 and miR-182 all had lower expression levels in uveal melanoma cell lines, compared with normal cells" -tissue_expression_down hsa-mir-155 Choriocarcinoma 24007214 There were low expressions of exosomal miR-155 and miR-196a in serum samples of PC patients when U-6 was used as a control. Serum exosomal miR-17-5p was higher in PC patients than in non-PC patients and healthy participants. -tissue_expression_down hsa-mir-196a Choriocarcinoma 24007214 There were low expressions of exosomal miR-155 and miR-196a in serum samples of PC patients when U-6 was used as a control. Serum exosomal miR-17-5p was higher in PC patients than in non-PC patients and healthy participants. -tissue_expression_down hsa-mir-33a "Carcinoma, Hepatocellular" 24015284 miR-33a down-regulated ¦Â-catenin by directly binding to the 3'-UTR of ¦Â-catenin. These results suggested that AFB1 might down-regulate ¦Â-catenin by up-regulating miR-33a. This understanding opens new lines of thought in the potential role of miR-33a in the clinical therapy of cancer. -tissue_expression_down hsa-mir-199a Lung Neoplasms 24022342 downregulation of miR-199a is essential for hypoxia-induced proliferation through derepressing the expression of HIF1a expression and affecting HIF1a mediated glycolytic pathway in NSCLC progression. -tissue_expression_down hsa-mir-16 Colorectal Carcinoma 24045965 Down-regulation of miR-16 plays critical roles in CRC progression.Low miR-16 expression is an independent factor predicting a poor prognosis for CRC patients. -tissue_expression_down hsa-mir-370 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 24055400 "In conclusion, our results suggest that miR-370 may function as a tumor suppressor in LSCC through downregulation of FoxM1,suggesting that miR-370 could serve as a novel potential maker for LSCC therapy." -tissue_expression_down hsa-mir-138 Neoplasms [unspecific] 24057215 MiR-138 downregulates miRNA processing in HeLa cells by targeting RMND5A and decreasing Exportin-5 stability. -tissue_expression_down hsa-mir-199a "Carcinoma, Gastric" 24065659 MicroRNA-199a-3p is downregulated in gastric carcinomas and modulates cell proliferation. -tissue_expression_down hsa-let-7f "Leukemia, Myeloid, Acute" 24067109 MicroRNA let-7f is down-regulated in patients with refractory acute myeloid leukemia and is involved in chemotherapy resistance of adriamycin-resistant leukemic cells. -tissue_expression_down hsa-let-7b Primary Biliary Cirrhosis 24074714 "Decreased expression of miR-let-7b may be associated with development and progression of PBC, and this miRNA may represent a novel target of improved diagnostic and preventive strategies for PBC." -tissue_expression_down hsa-mir-27a Intervertebral Disc Degeneration 24086481 This present study revealed that downregulated miR-27a might develop a novel intervention for IDD treatment through the prevention of apoptosis in Nucleus pulposus Cells. -tissue_expression_down hsa-mir-487b Cardiovascular Diseases [unspecific] 24096771 "Angiotensin II-induced hypertension leads to upregulation of miR-487b, which targets IRS1. Via downregulation of IRS1, miR-487b can contribute to cell death and loss of adventitial and medial integrity during hypertension-induced vascular pathology." -tissue_expression_down hsa-mir-760 Gastric Neoplasms 24097871 "Histone mRNA was upregulated, whereas miR-760 was downregulated in the bone marrow and primary tumor of advanced gastric cancer patients, suggesting that the histone mRNA/miR-760 axis had a crucial role in the development of gastric cancer." -tissue_expression_down hsa-mir-30c "Carcinoma, Renal Cell" 24112779 "hypoxia induces EMT in RCC cells through downregulation of miR-30c, which leads to subsequent increase of Slug expression and repression of E-cadherin production, and suggest a potential application of miR-30c in RCC treatment." -tissue_expression_down hsa-mir-34a Ischemic Heart Disease 24123326 "miR-34a was downregulated in heat shocked Sca-11 stem cells (HSSca-11 cells),heat shock induces exosomal transfer of HSF1 from Sca-1(+) cells, which directs ischemic cardiomyocytes toward a prosurvival phenotype by epigenetic repression of miR-34a." -tissue_expression_down hsa-mir-214 "Carcinoma, Hepatocellular" 24129885 "the upregulation of miR-130b and downregulation of miR-199a-5p, miR-199b-5p, and miR-214 were more significant in HCC cell lines" -tissue_expression_down hsa-mir-149 "Carcinoma, Renal Cell" 24137408 "miR-141, miR-149 and miR-429 were downregulated in the ccRCC tissues" -tissue_expression_down hsa-mir-29c "Leukemia, Lymphocytic, Chronic, B-Cell" 24138306 down-regulation of miR-29c is associated with higher tumor burden and significantly predicts short survival in Chinese patients with CLL -tissue_expression_down hsa-mir-661 Breast Neoplasms 24141721 miR-661 downregulates both Mdm2 and Mdm4 to activate p53. -tissue_expression_down hsa-mir-497 Breast Neoplasms 24143964 "downregulation of miR-497 was correlated with BC progression, and miR-497 might be a potential molecular biomarker for predicting the prognosis of patients." -tissue_expression_down hsa-mir-25 "Muscular Dystrophy, Facioscapulohumeral" 24145033 "eight were down-regulated (miR-15b, miR-20b, miR-21, miR-25, miR-100, miR-155, miR-345, and miR-594)" -tissue_expression_down hsa-mir-370 "Leukemia, Myeloid, Chronic" 24148180 MiR-370 sensitized K562 cells to HHT by inducing apoptosis in part by downregulation of FoxM1 expression. These findings may provide further information for CML treatment with HHT. -tissue_expression_down hsa-mir-16 Pleural Mesothelioma 24148817 The miR-15/16 family is downregulated and has tumour suppressor function in MPM. Restoring miR-16 expression represents a novel therapeutic approach for MPM. -tissue_expression_down hsa-mir-141 Esophageal Neoplasms 24155113 "The statistical significance of downregulation in hsa-miR-301a, hsa-miR-141 and hsa-miR-18b expression (P??90% of the 991 lung cancer samples" -tissue_expression_down hsa-mir-490 Lung Neoplasms 28334118 "we found that hsa-mir-210 was upregulated, while hsa-mir-490 and hsa-mir-486 were downregulated in?>?90% of the 991 lung cancer samples" -tissue_expression_down hsa-let-7f Ischemia 28345812 Reduced expression of let-7f activates TGF-¦Â/ALK5 pathway and leads to impaired ischaemia-induced neovascularization after cigarette smoke exposure. -tissue_expression_down hsa-mir-197 "Fibromatosis, Aggressive" 28418912 "The correlation between sporadic DTs and miRNA expression showed that miR-21-3p increased in mutated versus wild-type DTs, while miR-197-3p was decreased" -tissue_expression_down hsa-mir-29b Breast Neoplasms 28465475 Down-regulation of miR-29b in carcinoma associated fibroblasts promotes cell growth and metastasis of breast cancer. -tissue_expression_down hsa-mir-148a "Carcinoma, Gastric" 28475823 Down-regulated miRs specifically correlate with non-cardial gastric cancers and Lauren's classification system. -tissue_expression_down hsa-mir-204 "Carcinoma, Gastric" 28475823 Down-regulated miRs specifically correlate with non-cardial gastric cancers and Lauren's classification system. -tissue_expression_down hsa-mir-31 "Carcinoma, Gastric" 28475823 Down-regulated miRs specifically correlate with non-cardial gastric cancers and Lauren's classification system. -tissue_expression_down hsa-mir-375 "Carcinoma, Gastric" 28475823 Down-regulated miRs specifically correlate with non-cardial gastric cancers and Lauren's classification system. -tissue_expression_down hsa-mir-155 Behcet Disease 28482290 "up regulation of miR-182 and miR-3591-3p; down regulation of miR-155, miR-638 and miR-4488 in the pathogenesis of the disease" -tissue_expression_down hsa-mir-4488 Behcet Disease 28482290 "up regulation of miR-182 and miR-3591-3p; down regulation of miR-155, miR-638 and miR-4488 in the pathogenesis of the disease" -tissue_expression_down hsa-mir-638 Behcet Disease 28482290 "up regulation of miR-182 and miR-3591-3p; down regulation of miR-155, miR-638 and miR-4488 in the pathogenesis of the disease" -tissue_expression_down hsa-mir-200b Colon Neoplasms 28552992 MicroRNA-200b is downregulated in colon cancer budding cells. -tissue_expression_down hsa-mir-1 Pituitary Neoplasms 28577032 "Studies have shown that the levels of miR-1, miR-195, and miR-206 are downregulated in Pas" -tissue_expression_down hsa-mir-195 Pituitary Neoplasms 28577032 "Studies have shown that the levels of miR-1, miR-195, and miR-206 are downregulated in Pas" -tissue_expression_down hsa-mir-206 Pituitary Neoplasms 28577032 "Studies have shown that the levels of miR-1, miR-195, and miR-206 are downregulated in Pas" -tissue_expression_down hsa-mir-200b Liver Cirrhosis 28634212 Prolonged darkness reduces liver fibrosis in a mouse model of primary sclerosing cholangitis by miR-200b down-regulation. -tissue_expression_down hsa-mir-146a Obesity 28652200 Down-regulation of miRNAs in the brain and development of diet-induced obesity -tissue_expression_down hsa-mir-155 Obesity 28652200 Down-regulation of miRNAs in the brain and development of diet-induced obesity. -tissue_expression_down hsa-mir-451 "Carcinoma, Lung, Non-Small-Cell" 28704499 The low expression of miR-451 predicts a worse prognosis in non-small cell lung cancer cases. -tissue_expression_down hsa-mir-122 Stroke 28751928 A Decrease of Brain MicroRNA-122 Level Is an Early Marker of Cerebrovascular Disease in the Stroke-Prone Spontaneously Hypertensive Rat. -tissue_expression_down hsa-mir-138 "Squamous Cell Carcinoma, Esophageal" 28759955 Downregulation of miR-138 predicts poor prognosis in patients with esophageal squamous cell carcinoma -tissue_expression_down hsa-mir-15 Chronic Kidney Disease 28771472 MicroRNAs in the miR-17 and miR-15 families are downregulated in chronic kidney disease with hypertension. -tissue_expression_down hsa-mir-17 Chronic Kidney Disease 28771472 MicroRNAs in the miR-17 and miR-15 families are downregulated in chronic kidney disease with hypertension. -tissue_expression_down hsa-mir-190b Vasomotor Rhinitis 28787742 "there was significant overexpression of miR-543, miR-129-5p, and miR-126-3p, and under-expression of miR-2110, miR-449c-5p, miR-449b-5p, miR-190b, and miR-92b-5p." -tissue_expression_down hsa-mir-2110 Vasomotor Rhinitis 28787742 "there was significant overexpression of miR-543, miR-129-5p, and miR-126-3p, and under-expression of miR-2110, miR-449c-5p, miR-449b-5p, miR-190b, and miR-92b-5p." -tissue_expression_down hsa-mir-449b Vasomotor Rhinitis 28787742 "there was significant overexpression of miR-543, miR-129-5p, and miR-126-3p, and under-expression of miR-2110, miR-449c-5p, miR-449b-5p, miR-190b, and miR-92b-5p." -tissue_expression_down hsa-mir-449c Vasomotor Rhinitis 28787742 "there was significant overexpression of miR-543, miR-129-5p, and miR-126-3p, and under-expression of miR-2110, miR-449c-5p, miR-449b-5p, miR-190b, and miR-92b-5p." -tissue_expression_down hsa-mir-92b Vasomotor Rhinitis 28787742 "there was significant overexpression of miR-543, miR-129-5p, and miR-126-3p, and under-expression of miR-2110, miR-449c-5p, miR-449b-5p, miR-190b, and miR-92b-5p." -tissue_expression_down hsa-mir-17 "Lymphoma, Large B-Cell, Diffuse" 28817403 "PB-DLBCL and DLBCL-GCB-CC also had much higher levels of miR-125a-3p, miR-34-3p, and miR-155-5p, and significantly lower levels of miR-17-5p and miR-17-3p" -tissue_expression_down hsa-mir-200b Colon Neoplasms 28821160 "downregulation of AKT, NF-¦ÊB, Bcl-XL expressions and some key oncomicroRNAs such as miRNA-21 and miRNA-200b significantly" -tissue_expression_down hsa-mir-21 Colon Neoplasms 28821160 "downregulation of AKT, NF-¦ÊB, Bcl-XL expressions and some key oncomicroRNAs such as miRNA-21 and miRNA-200b significantly" -tissue_expression_down hsa-let-7a Lung Neoplasms 28846189 "Let-7a, miR-16 and miR-34a, were found to be significantly downregulated by chronic PM2.5 exposure" -tissue_expression_down hsa-mir-16 Lung Neoplasms 28846189 "Let-7a, miR-16 and miR-34a, were found to be significantly downregulated by chronic PM2.5 exposure" -tissue_expression_down hsa-mir-34a Lung Neoplasms 28846189 "Let-7a, miR-16 and miR-34a, were found to be significantly downregulated by chronic PM2.5 exposure" -tissue_expression_down hsa-mir-148a Colorectal Carcinoma 28863773 Down-regulation of miRNA-148a and miRNA-625-3p in colorectal cancer is associated with tumor budding. -tissue_expression_down hsa-mir-625 Colorectal Carcinoma 28863773 Down-regulation of miRNA-148a and miRNA-625-3p in colorectal cancer is associated with tumor budding. -tissue_expression_down hsa-mir-221 Prostate Neoplasms 28886115 Androgen receptor-mediated downregulation of microRNA-221 and -222 in castration-resistant prostate cancer. -tissue_expression_down hsa-mir-222 Prostate Neoplasms 28886115 Androgen receptor-mediated downregulation of microRNA-221 and -222 in castration-resistant prostate cancer. -tissue_expression_down hsa-mir-21 Alcoholic Cardiomyopathy 29039471 "The present study confirmed that H2S relieves myocardial fibrosis in mice with ACM, and the underlying mechanism may involve the downregulation of autophagy and miR-21 and miR-211 expression levels." -tissue_expression_down hsa-mir-221 Alcoholic Cardiomyopathy 29039471 "The present study confirmed that H2S relieves myocardial fibrosis in mice with ACM, and the underlying mechanism may involve the downregulation of autophagy and miR-21 and miR-211 expression levels." -tissue_expression_down hsa-mir-199a Ovarian Germ Cell Cancer 29138809 "Higher expression of miR-373-3p, miR-372-3p and miR-302c-3p and lower expression of miR-199a-5p, miR-214-5p and miR-202-3p were reproducibly observed in malignant OGCTs as compared to benign OGCTs or SCSTs" -tissue_expression_down hsa-mir-202 Ovarian Germ Cell Cancer 29138809 "Higher expression of miR-373-3p, miR-372-3p and miR-302c-3p and lower expression of miR-199a-5p, miR-214-5p and miR-202-3p were reproducibly observed in malignant OGCTs as compared to benign OGCTs or SCSTs" -tissue_expression_down hsa-mir-214 Ovarian Germ Cell Cancer 29138809 "Higher expression of miR-373-3p, miR-372-3p and miR-302c-3p and lower expression of miR-199a-5p, miR-214-5p and miR-202-3p were reproducibly observed in malignant OGCTs as compared to benign OGCTs or SCSTs" -tissue_expression_down hsa-mir-1 Myocardial Infarction 29162889 "The expression level of miR-143 in monocytes from STEMI patients compared to healthy controls was increased, whereas the expression of miR-1, -92a, -99a, and -223 was reduced significantly" -tissue_expression_down hsa-mir-223 Myocardial Infarction 29162889 "The expression level of miR-143 in monocytes from STEMI patients compared to healthy controls was increased, whereas the expression of miR-1, -92a, -99a, and -223 was reduced significantly" -tissue_expression_down hsa-mir-92a Myocardial Infarction 29162889 "The expression level of miR-143 in monocytes from STEMI patients compared to healthy controls was increased, whereas the expression of miR-1, -92a, -99a, and -223 was reduced significantly" -tissue_expression_down hsa-mir-99a Myocardial Infarction 29162889 "The expression level of miR-143 in monocytes from STEMI patients compared to healthy controls was increased, whereas the expression of miR-1, -92a, -99a, and -223 was reduced significantly" -tissue_expression_down hsa-mir-125b Ovarian Neoplasms 29307001 "miR-26a, miR-125b-5p, miR-17-5p and miR-221 downregulation could be related to poor EOC prognosis" -tissue_expression_down hsa-mir-17 Ovarian Neoplasms 29307001 "miR-26a, miR-125b-5p, miR-17-5p and miR-221 downregulation could be related to poor EOC prognosis" -tissue_expression_down hsa-mir-221 Ovarian Neoplasms 29307001 "miR-26a, miR-125b-5p, miR-17-5p and miR-221 downregulation could be related to poor EOC prognosis" -tissue_expression_down hsa-mir-26a Ovarian Neoplasms 29307001 "miR-26a, miR-125b-5p, miR-17-5p and miR-221 downregulation could be related to poor EOC prognosis" -tissue_expression_down hsa-let-7a "Carcinoma, Hepatocellular" 29314614 "miR-1, miR-122, let-7a, and let-7g were downregulated, whereas miR-10b and miR-21 were upregulated in canine HCC" -tissue_expression_down hsa-let-7g "Carcinoma, Hepatocellular" 29314614 "miR-1, miR-122, let-7a, and let-7g were downregulated, whereas miR-10b and miR-21 were upregulated in canine HCC" -tissue_expression_down hsa-mir-1 "Carcinoma, Hepatocellular" 29314614 "miR-1, miR-122, let-7a, and let-7g were downregulated, whereas miR-10b and miR-21 were upregulated in canine HCC" -tissue_expression_down hsa-mir-122 "Carcinoma, Hepatocellular" 29314614 "miR-1, miR-122, let-7a, and let-7g were downregulated, whereas miR-10b and miR-21 were upregulated in canine HCC" -tissue_expression_down hsa-mir-145 NUT Midline Carcinoma 29322795 "All NMCs showed upregulation of miR-9 and downregulation of miR-99a and miR-145 and two cases featured also upregulation of miR-21, miR-143, and miR-484" -tissue_expression_down hsa-mir-99a NUT Midline Carcinoma 29322795 "All NMCs showed upregulation of miR-9 and downregulation of miR-99a and miR-145 and two cases featured also upregulation of miR-21, miR-143, and miR-484" -tissue_expression_down hsa-mir-125 Infection [unspecific] 29391047 "upregulated miR-21, miR-155, miR-150, and miR-221, as well as downregulated miR-143 and miR-125, all of them previously linked to other bacterial infections" -tissue_expression_down hsa-mir-143 Infection [unspecific] 29391047 "upregulated miR-21, miR-155, miR-150, and miR-221, as well as downregulated miR-143 and miR-125, all of them previously linked to other bacterial infections" -tissue_expression_down hsa-let-7i Hepatoblastoma 29404451 "Let-7i-3p, miR-449b-3p, miR-624-5p, and miR-885-5p were decreased in tumors compared to normal livers" -tissue_expression_down hsa-mir-449b Hepatoblastoma 29404451 "Let-7i-3p, miR-449b-3p, miR-624-5p, and miR-885-5p were decreased in tumors compared to normal livers" -tissue_expression_down hsa-mir-624 Hepatoblastoma 29404451 "Let-7i-3p, miR-449b-3p, miR-624-5p, and miR-885-5p were decreased in tumors compared to normal livers" -tissue_expression_down hsa-mir-885 Hepatoblastoma 29404451 "Let-7i-3p, miR-449b-3p, miR-624-5p, and miR-885-5p were decreased in tumors compared to normal livers" -tissue_expression_down hsa-mir-129 Infection [unspecific] 29425228 "Seven of the 26 miRNAs, miR-99b-5p, miR-129-3p, miR-188-5p, miR-363-3p, miR-1295a, miR-4443 and miR-6721-5p, showed significantly decreased expression in individuals with detectable oral shedding" -tissue_expression_down hsa-mir-1295a Infection [unspecific] 29425228 "Seven of the 26 miRNAs, miR-99b-5p, miR-129-3p, miR-188-5p, miR-363-3p, miR-1295a, miR-4443 and miR-6721-5p, showed significantly decreased expression in individuals with detectable oral shedding" -tissue_expression_down hsa-mir-188 Infection [unspecific] 29425228 "Seven of the 26 miRNAs, miR-99b-5p, miR-129-3p, miR-188-5p, miR-363-3p, miR-1295a, miR-4443 and miR-6721-5p, showed significantly decreased expression in individuals with detectable oral shedding" -tissue_expression_down hsa-mir-363 Infection [unspecific] 29425228 "Seven of the 26 miRNAs, miR-99b-5p, miR-129-3p, miR-188-5p, miR-363-3p, miR-1295a, miR-4443 and miR-6721-5p, showed significantly decreased expression in individuals with detectable oral shedding" -tissue_expression_down hsa-mir-4443 Infection [unspecific] 29425228 "Seven of the 26 miRNAs, miR-99b-5p, miR-129-3p, miR-188-5p, miR-363-3p, miR-1295a, miR-4443 and miR-6721-5p, showed significantly decreased expression in individuals with detectable oral shedding" -tissue_expression_down hsa-mir-6721 Infection [unspecific] 29425228 "Seven of the 26 miRNAs, miR-99b-5p, miR-129-3p, miR-188-5p, miR-363-3p, miR-1295a, miR-4443 and miR-6721-5p, showed significantly decreased expression in individuals with detectable oral shedding" -tissue_expression_down hsa-mir-99b Infection [unspecific] 29425228 "Seven of the 26 miRNAs, miR-99b-5p, miR-129-3p, miR-188-5p, miR-363-3p, miR-1295a, miR-4443 and miR-6721-5p, showed significantly decreased expression in individuals with detectable oral shedding" -tissue_expression_down hsa-mir-192 "Carcinoma, Renal Cell" 29440068 miR-192 and miR-194 as downregulated -tissue_expression_down hsa-mir-194 "Carcinoma, Renal Cell" 29440068 miR-192 and miR-194 as downregulated -tissue_expression_down hsa-mir-125a "Squamous Cell Carcinoma, Oral" 29480379 increased miR-21 levels in conjunction with decreased miR-125a levels in saliva of OLP patients may be indicative for a poor prognosis -tissue_expression_down hsa-mir-34a Cervical Neoplasms 29487007 "MiR-21-5p upregulation, miR-34a downregulation, and hTERC amplification were associated with the aggressive progression of CC, which suggests that miR-21-5p, miR-34a and hTERC might serve as surrogate markers for CC progression and potential molecular targets for blockage of the development of CC" -tissue_expression_down hsa-mir-126 Lung Neoplasms 29516903 "the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs" -tissue_expression_down hsa-mir-143 Lung Neoplasms 29516903 "the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs" -tissue_expression_down hsa-mir-145 Lung Neoplasms 29516903 "the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs" -tissue_expression_down hsa-mir-30a Lung Neoplasms 29516903 "the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs" -tissue_expression_down hsa-mir-30d Lung Neoplasms 29516903 "the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs" -tissue_expression_down hsa-mir-451a Lung Neoplasms 29516903 "the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs" -tissue_expression_down hsa-mir-486 Lung Neoplasms 29516903 "the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs" -tissue_expression_down hsa-mir-196b Ovarian Neoplasms 29518404 "Specifically, miR-196b, miR-532, miR-886-3b, and miR-99b exhibited lower levels in HGOSC compared with USC, whereas miR-29c, miR-155, miR-454, miR-146b-5p, miR-486-5p, miR-27a, miR-192, and miR-141 exhibited significantly higher expression in HGOSC samples" -tissue_expression_down hsa-mir-532 Ovarian Neoplasms 29518404 "Specifically, miR-196b, miR-532, miR-886-3b, and miR-99b exhibited lower levels in HGOSC compared with USC, whereas miR-29c, miR-155, miR-454, miR-146b-5p, miR-486-5p, miR-27a, miR-192, and miR-141 exhibited significantly higher expression in HGOSC samples" -tissue_expression_down hsa-mir-886 Ovarian Neoplasms 29518404 "Specifically, miR-196b, miR-532, miR-886-3b, and miR-99b exhibited lower levels in HGOSC compared with USC, whereas miR-29c, miR-155, miR-454, miR-146b-5p, miR-486-5p, miR-27a, miR-192, and miR-141 exhibited significantly higher expression in HGOSC samples" -tissue_expression_down hsa-mir-99b Ovarian Neoplasms 29518404 "Specifically, miR-196b, miR-532, miR-886-3b, and miR-99b exhibited lower levels in HGOSC compared with USC, whereas miR-29c, miR-155, miR-454, miR-146b-5p, miR-486-5p, miR-27a, miR-192, and miR-141 exhibited significantly higher expression in HGOSC samples" -tissue_expression_down hsa-mir-101 "Squamous Cell Carcinoma, Oral" 29533734 "Poor prognosis correlated with upregulation of 9 miRNAs (miR-21, miR-455-5p, miiR-155-5p, miR-372, miR-373, miR-29b, miR-1246, miR-196a, and miR-181) and downregulation of 7 miRNAs (miR-204, miR-101, miR-32, miR-20a, miR-16, miR-17, and miR-125b)" -tissue_expression_down hsa-mir-125b "Squamous Cell Carcinoma, Oral" 29533734 "Poor prognosis correlated with upregulation of 9 miRNAs (miR-21, miR-455-5p, miiR-155-5p, miR-372, miR-373, miR-29b, miR-1246, miR-196a, and miR-181) and downregulation of 7 miRNAs (miR-204, miR-101, miR-32, miR-20a, miR-16, miR-17, and miR-125b)" -tissue_expression_down hsa-mir-16 "Squamous Cell Carcinoma, Oral" 29533734 "Poor prognosis correlated with upregulation of 9 miRNAs (miR-21, miR-455-5p, miiR-155-5p, miR-372, miR-373, miR-29b, miR-1246, miR-196a, and miR-181) and downregulation of 7 miRNAs (miR-204, miR-101, miR-32, miR-20a, miR-16, miR-17, and miR-125b)" -tissue_expression_down hsa-mir-17 "Squamous Cell Carcinoma, Oral" 29533734 "Poor prognosis correlated with upregulation of 9 miRNAs (miR-21, miR-455-5p, miiR-155-5p, miR-372, miR-373, miR-29b, miR-1246, miR-196a, and miR-181) and downregulation of 7 miRNAs (miR-204, miR-101, miR-32, miR-20a, miR-16, miR-17, and miR-125b)" -tissue_expression_down hsa-mir-204 "Squamous Cell Carcinoma, Oral" 29533734 "Poor prognosis correlated with upregulation of 9 miRNAs (miR-21, miR-455-5p, miiR-155-5p, miR-372, miR-373, miR-29b, miR-1246, miR-196a, and miR-181) and downregulation of 7 miRNAs (miR-204, miR-101, miR-32, miR-20a, miR-16, miR-17, and miR-125b)" -tissue_expression_down hsa-mir-20a "Squamous Cell Carcinoma, Oral" 29533734 "Poor prognosis correlated with upregulation of 9 miRNAs (miR-21, miR-455-5p, miiR-155-5p, miR-372, miR-373, miR-29b, miR-1246, miR-196a, and miR-181) and downregulation of 7 miRNAs (miR-204, miR-101, miR-32, miR-20a, miR-16, miR-17, and miR-125b)" -tissue_expression_down hsa-mir-32 "Squamous Cell Carcinoma, Oral" 29533734 "Poor prognosis correlated with upregulation of 9 miRNAs (miR-21, miR-455-5p, miiR-155-5p, miR-372, miR-373, miR-29b, miR-1246, miR-196a, and miR-181) and downregulation of 7 miRNAs (miR-204, miR-101, miR-32, miR-20a, miR-16, miR-17, and miR-125b)" -tissue_expression_down hsa-mir-124 Glioblastoma 29559295 "In our microarray data, lower expression of miR-219-5p, miR-124, and miR-128 and higher expression of miR-21 was observed in GBM compared with the peripheral region, similar to the results of previous reports" -tissue_expression_down hsa-mir-128 Glioblastoma 29559295 "In our microarray data, lower expression of miR-219-5p, miR-124, and miR-128 and higher expression of miR-21 was observed in GBM compared with the peripheral region, similar to the results of previous reports" -tissue_expression_down hsa-mir-219 Glioblastoma 29559295 "In our microarray data, lower expression of miR-219-5p, miR-124, and miR-128 and higher expression of miR-21 was observed in GBM compared with the peripheral region, similar to the results of previous reports" -tissue_expression_down hsa-mir-3127 "Carcinoma, Lung, Non-Small-Cell" 29566281 Downregulation of miR-3127-5p promotes epithelial-mesenchymal transition via FZD4 regulation of Wnt/¦Â-catenin signaling in non-small-cell lung cancer. -tissue_expression_down hsa-mir-135b Prostate Neoplasms 29568403 "top nine miRNA with significantly lower expression level in ExoHypoxic compared to ExoNormoxic were miR-521, miR-27a, miR-324, miR-579, miR-502, miR-222, miR-135b, miR-146a and miR-491." -tissue_expression_down hsa-mir-146a Prostate Neoplasms 29568403 "top nine miRNA with significantly lower expression level in ExoHypoxic compared to ExoNormoxic were miR-521, miR-27a, miR-324, miR-579, miR-502, miR-222, miR-135b, miR-146a and miR-492." -tissue_expression_down hsa-mir-222 Prostate Neoplasms 29568403 "top nine miRNA with significantly lower expression level in ExoHypoxic compared to ExoNormoxic were miR-521, miR-27a, miR-324, miR-579, miR-502, miR-222, miR-135b, miR-146a and miR-491." -tissue_expression_down hsa-mir-27a Prostate Neoplasms 29568403 "top nine miRNA with significantly lower expression level in ExoHypoxic compared to ExoNormoxic were miR-521, miR-27a, miR-324, miR-579, miR-502, miR-222, miR-135b, miR-146a and miR-491." -tissue_expression_down hsa-mir-324 Prostate Neoplasms 29568403 "top nine miRNA with significantly lower expression level in ExoHypoxic compared to ExoNormoxic were miR-521, miR-27a, miR-324, miR-579, miR-502, miR-222, miR-135b, miR-146a and miR-491." -tissue_expression_down hsa-mir-491 Prostate Neoplasms 29568403 "top nine miRNA with significantly lower expression level in ExoHypoxic compared to ExoNormoxic were miR-521, miR-27a, miR-324, miR-579, miR-502, miR-222, miR-135b, miR-146a and miR-492." -tissue_expression_down hsa-mir-502 Prostate Neoplasms 29568403 "top nine miRNA with significantly lower expression level in ExoHypoxic compared to ExoNormoxic were miR-521, miR-27a, miR-324, miR-579, miR-502, miR-222, miR-135b, miR-146a and miR-491." -tissue_expression_down hsa-mir-521 Prostate Neoplasms 29568403 "top nine miRNA with significantly lower expression level in ExoHypoxic compared to ExoNormoxic were miR-521, miR-27a, miR-324, miR-579, miR-502, miR-222, miR-135b, miR-146a and miR-491." -tissue_expression_down hsa-mir-579 Prostate Neoplasms 29568403 "top nine miRNA with significantly lower expression level in ExoHypoxic compared to ExoNormoxic were miR-521, miR-27a, miR-324, miR-579, miR-502, miR-222, miR-135b, miR-146a and miR-491." -tissue_expression_down hsa-mir-145 "Carcinoma, Endometrioid Endometrial" 29569698 miRNA-145 expression was lower in DPEEOC endometrial tissues and higher in DPEEOC ovarian tissues compared to the corresponding normal tissues -tissue_expression_down hsa-mir-143 "Carcinoma, Hepatocellular, HBV-Related" 29616093 "These results indicated that the decreased expression of the miR-143/145 cluster and their host gene MIR143HG in HBV-associated HCC tissue was associated with prognosis, and each of these miRNAs may serve as a valuable diagnostic biomarker for predicting HBV-associated HCC tumorigenesis" -tissue_expression_down hsa-mir-145 "Carcinoma, Hepatocellular, HBV-Related" 29616093 "These results indicated that the decreased expression of the miR-143/145 cluster and their host gene MIR143HG in HBV-associated HCC tissue was associated with prognosis, and each of these miRNAs may serve as a valuable diagnostic biomarker for predicting HBV-associated HCC tumorigenesis" -tissue_expression_down hsa-mir-145 Urinary System Cancer 29623292 the decline of miR-145 expression level have been proved to be able to distinguish bladder cancer patients from non-cancer controls in cell-free urine samples; the elevation of miR-10a and miR-30d was also observed in urine samples from patients with focal segmental glomerulosclerosis -tissue_expression_down hsa-mir-126 Atherosclerosis 29642385 "Moreover, the expression level of miR-126 tended to be downregulated and that of miR-21 tended to be upregulated in ApoE KO mice exposed to the high dose of CS, albeit statistically insignificant" -tissue_expression_down hsa-mir-126 Myocardial Infarction 29642385 "Moreover, the expression level of miR-126 tended to be downregulated and that of miR-21 tended to be upregulated in ApoE KO mice exposed to the high dose of CS, albeit statistically insignificant" -tissue_expression_down hsa-mir-126 Stroke 29642385 "Moreover, the expression level of miR-126 tended to be downregulated and that of miR-21 tended to be upregulated in ApoE KO mice exposed to the high dose of CS, albeit statistically insignificant" -tissue_expression_down hsa-mir-7 Myasthenia Gravis 29655674 miR-7 was the most down-regulated thymic miRNA in MG -tissue_expression_down hsa-mir-10a Ependymoma 29658967 low expression of miR-10a and over-expression of miR-10b and miR-29a in ependymoma -tissue_expression_down hsa-mir-181c Medulloblastoma 29658967 "Low-expression of miR-221, miR-9, and miR-181c/d and over-expression of miR-101, miR-222, miR-139, miR-1827, and miR-34c was found in medulloblastoma" -tissue_expression_down hsa-mir-181d Medulloblastoma 29658967 "Low-expression of miR-221, miR-9, and miR-181c/d and over-expression of miR-101, miR-222, miR-139, miR-1827, and miR-34c was found in medulloblastoma" -tissue_expression_down hsa-mir-221 Medulloblastoma 29658967 "Low-expression of miR-221, miR-9, and miR-181c/d and over-expression of miR-101, miR-222, miR-139, miR-1827, and miR-34c was found in medulloblastoma" -tissue_expression_down hsa-mir-26a Glioma 29658967 "low expression of miR-26a and overexpression of miR-19a/b, miR-24, miR-27a, miR- 584, and miR-527 in low-grade glioma" -tissue_expression_down hsa-mir-9 Medulloblastoma 29658967 "Low-expression of miR-221, miR-9, and miR-181c/d and over-expression of miR-101, miR-222, miR-139, miR-1827, and miR-34c was found in medulloblastoma" -tissue_expression_down hsa-mir-203 "Squamous Cell Carcinoma, Head and Neck" 29667275 "miR-26 and miR-125b may be associated with the progression and metastasis of HNSCC, and that miR-203 is associated with a more favourable prognosis." -tissue_expression_down hsa-mir-26b "Carcinoma, Breast" 29689244 Decreased expression of microRNA-26b in locally advanced and inflammatory breast cancer. -tissue_expression_down hsa-mir-3098 Alcoholic Cardiomyopathy 29734191 The results demonstrated that miR-467d-3p and miR-491-5p were up-regulated and miR-3098-3p was down-regulated in the alcohol-exposed myocardial samples compared with the control samples (P < 0.05). -tissue_expression_down hsa-mir-188 "Carcinoma, Cervical" 29737570 the low expression of miR-188 and high expression of miR-223 correlated with the short survival of CC patients -tissue_expression_down hsa-mir-197 Chronic Obstructive Pulmonary Disease 29757677 "expression levels of miR-98, miR-139-5p, miR-146b-5p, and miR-451 were upregulated, as compared with NS. In contrast, miR-197, miR-204, miR-485-3p, and miR-627 were downregulated." -tissue_expression_down hsa-mir-204 Chronic Obstructive Pulmonary Disease 29757677 "expression levels of miR-98, miR-139-5p, miR-146b-5p, and miR-451 were upregulated, as compared with NS. In contrast, miR-197, miR-204, miR-485-3p, and miR-627 were downregulated." -tissue_expression_down hsa-mir-485 Chronic Obstructive Pulmonary Disease 29757677 "expression levels of miR-98, miR-139-5p, miR-146b-5p, and miR-451 were upregulated, as compared with NS. In contrast, miR-197, miR-204, miR-485-3p, and miR-627 were downregulated." -tissue_expression_down hsa-mir-627 Chronic Obstructive Pulmonary Disease 29757677 "expression levels of miR-98, miR-139-5p, miR-146b-5p, and miR-451 were upregulated, as compared with NS. In contrast, miR-197, miR-204, miR-485-3p, and miR-627 were downregulated." -tissue_expression_down hsa-let-7c "Squamous Cell Carcinoma, Oral" 29764807 "Upregulation of miR-31 and miR-21 and downregulation of miR-99a, let-7c, miR-125b, and miR-100 were found between OSCC and controls" -tissue_expression_down hsa-mir-100 "Squamous Cell Carcinoma, Oral" 29764807 "Upregulation of miR-31 and miR-21 and downregulation of miR-99a, let-7c, miR-125b, and miR-100 were found between OSCC and controls" -tissue_expression_down hsa-mir-125b "Squamous Cell Carcinoma, Oral" 29764807 "Upregulation of miR-31 and miR-21 and downregulation of miR-99a, let-7c, miR-125b, and miR-100 were found between OSCC and controls" -tissue_expression_down hsa-mir-99a "Squamous Cell Carcinoma, Oral" 29764807 "Upregulation of miR-31 and miR-21 and downregulation of miR-99a, let-7c, miR-125b, and miR-100 were found between OSCC and controls" -tissue_expression_down hsa-let-7 Gastric Neoplasms 29797599 "Our data showed that miR-146, miR-375, and Let-7 were down-regulated and miR-19 and miR-21 were up-regulated in GC patients with H. pylori infection" -tissue_expression_down hsa-mir-146 Gastric Neoplasms 29797599 "Our data showed that miR-146, miR-375, and Let-7 were down-regulated and miR-19 and miR-21 were up-regulated in GC patients with H. pylori infection" -tissue_expression_down hsa-mir-375 Gastric Neoplasms 29797599 "Our data showed that miR-146, miR-375, and Let-7 were down-regulated and miR-19 and miR-21 were up-regulated in GC patients with H. pylori infection" -tissue_expression_down hsa-mir-200a Chronic Kidney Disease 29909697 "We recognized in both meta-analysis approaches a significant miRNA meta-signature of five up-regulated (miR-142-3p, miR-223-3p, miR-21-5p, miR-142-5p and miR-214-3p) and two down-regulated (miR-29c-3p and miR-200a-3p) miRNAs" -tissue_expression_down hsa-mir-29c Chronic Kidney Disease 29909697 "We recognized in both meta-analysis approaches a significant miRNA meta-signature of five up-regulated (miR-142-3p, miR-223-3p, miR-21-5p, miR-142-5p and miR-214-3p) and two down-regulated (miR-29c-3p and miR-200a-3p) miRNAs" -tissue_expression_down hsa-mir-141 "Carcinoma, Breast, Triple Negative" 29923083 "(1) upregulated: miR-10b, miR-21, miR-29, miR-9, miR-221/222, miR-373 or (2) downregulated: miR-145, miR-199a-5p, miR-200 family, miR-203, miR-205 in TNBC" -tissue_expression_down hsa-mir-145 "Carcinoma, Breast, Triple Negative" 29923083 "(1) upregulated: miR-10b, miR-21, miR-29, miR-9, miR-221/222, miR-373 or (2) downregulated: miR-145, miR-199a-5p, miR-200 family, miR-203, miR-205 in TNBC" -tissue_expression_down hsa-mir-199a "Carcinoma, Breast, Triple Negative" 29923083 "(1) upregulated: miR-10b, miR-21, miR-29, miR-9, miR-221/222, miR-373 or (2) downregulated: miR-145, miR-199a-5p, miR-200 family, miR-203, miR-205 in TNBC" -tissue_expression_down hsa-mir-200a "Carcinoma, Breast, Triple Negative" 29923083 "(1) upregulated: miR-10b, miR-21, miR-29, miR-9, miR-221/222, miR-373 or (2) downregulated: miR-145, miR-199a-5p, miR-200 family, miR-203, miR-205 in TNBC" -tissue_expression_down hsa-mir-200b "Carcinoma, Breast, Triple Negative" 29923083 "(1) upregulated: miR-10b, miR-21, miR-29, miR-9, miR-221/222, miR-373 or (2) downregulated: miR-145, miR-199a-5p, miR-200 family, miR-203, miR-205 in TNBC" -tissue_expression_down hsa-mir-200c "Carcinoma, Breast, Triple Negative" 29923083 "(1) upregulated: miR-10b, miR-21, miR-29, miR-9, miR-221/222, miR-373 or (2) downregulated: miR-145, miR-199a-5p, miR-200 family, miR-203, miR-205 in TNBC" -tissue_expression_down hsa-mir-429 "Carcinoma, Breast, Triple Negative" 29923083 "(1) upregulated: miR-10b, miR-21, miR-29, miR-9, miR-221/222, miR-373 or (2) downregulated: miR-145, miR-199a-5p, miR-200 family, miR-203, miR-205 in TNBC" -tissue_expression_down hsa-mir-379 Oligodendroglioma 29931616 Identification of miR-379/miR-656 (C14MC) cluster downregulation and associated epigenetic and transcription regulatory mechanism in oligodendrogliomas. -tissue_expression_down hsa-mir-656 Oligodendroglioma 29931616 Identification of miR-379/miR-656 (C14MC) cluster downregulation and associated epigenetic and transcription regulatory mechanism in oligodendrogliomas. -tissue_expression_down hsa-mir-183 "Adenocarcinoma, Pancreatic Ductal" 29952976 the downregulated miR-183 level might be associated with poor prognosis in patients with melanoma and pancreatic ductal adenocarcinoma -tissue_expression_down hsa-mir-183 Melanoma 29952976 the downregulated miR-183 level might be associated with poor prognosis in patients with melanoma and pancreatic ductal adenocarcinoma -tissue_expression_down hsa-mir-490 "Carcinoma, Hepatocellular" 30007991 We found that miR-490-3p is down-regulated in HCC and is related to genes that have potential tumoral functions -tissue_expression_down hsa-mir-486 "Carcinoma, Thyroid, Papillary" 30015845 Downregulation of miR?486?5p in papillary thyroid carcinoma tissue: A study based on microarray and miRNA sequencing. -tissue_expression_down hsa-mir-29a Glioma 30016785 MicroRNA-29a-3p Downregulation Causes Gab1 Upregulation to Promote Glioma Cell Proliferation. -tissue_expression_down hsa-mir-187 Ovarian Neoplasms 30035102 low miR-187 and miR-489 expression was associated with poor prognosis -tissue_expression_down hsa-mir-489 Ovarian Neoplasms 30035102 low miR-187 and miR-489 expression was associated with poor prognosis -tissue_expression_down hsa-mir-204 Hepatitis B Virus Infection 30042818 "miR-204, strongly decreased both HBV DNA and HBsAg in culture supernatant of HepG2-hNTCP-C4 cells" -tissue_expression_down hsa-mir-128 Cholangiocarcinoma 30042823 "High miR-126, low miR-128 and TEMs were independent prognostic factors for recurrence-free and overall survival" -tissue_expression_down hsa-mir-126 Ovarian Neoplasms 30107086 "We report that miR-21 (P?=?0.0001), miR-100 (P?=?0.034), miR-200b (P?=?0.008), and miR-320 (P?=?0.034) are significantly enriched, whereas miR-16 (P?=?0.009), miR-93 (P?=?0.014), miR-126 (P?=?0.012), and miR-223 (P?=?0.029) are underrepresented in exosomes from plasma of EOC patients as compared to those of healthy women. The levels of exosomal miR-23a (P?=?0.009, 0.008) and miR-92a (P?=?009, 0.034) were lower in ovarian cystadenoma patients than in EOC patients and healthy women, respectively" -tissue_expression_down hsa-mir-16 Ovarian Neoplasms 30107086 "We report that miR-21 (P?=?0.0001), miR-100 (P?=?0.034), miR-200b (P?=?0.008), and miR-320 (P?=?0.034) are significantly enriched, whereas miR-16 (P?=?0.009), miR-93 (P?=?0.014), miR-126 (P?=?0.012), and miR-223 (P?=?0.029) are underrepresented in exosomes from plasma of EOC patients as compared to those of healthy women. The levels of exosomal miR-23a (P?=?0.009, 0.008) and miR-92a (P?=?009, 0.034) were lower in ovarian cystadenoma patients than in EOC patients and healthy women, respectively" -tissue_expression_down hsa-mir-223 Ovarian Neoplasms 30107086 "We report that miR-21 (P?=?0.0001), miR-100 (P?=?0.034), miR-200b (P?=?0.008), and miR-320 (P?=?0.034) are significantly enriched, whereas miR-16 (P?=?0.009), miR-93 (P?=?0.014), miR-126 (P?=?0.012), and miR-223 (P?=?0.029) are underrepresented in exosomes from plasma of EOC patients as compared to those of healthy women. The levels of exosomal miR-23a (P?=?0.009, 0.008) and miR-92a (P?=?009, 0.034) were lower in ovarian cystadenoma patients than in EOC patients and healthy women, respectively" -tissue_expression_down hsa-mir-23a Ovarian Neoplasms 30107086 "We report that miR-21 (P?=?0.0001), miR-100 (P?=?0.034), miR-200b (P?=?0.008), and miR-320 (P?=?0.034) are significantly enriched, whereas miR-16 (P?=?0.009), miR-93 (P?=?0.014), miR-126 (P?=?0.012), and miR-223 (P?=?0.029) are underrepresented in exosomes from plasma of EOC patients as compared to those of healthy women. The levels of exosomal miR-23a (P?=?0.009, 0.008) and miR-92a (P?=?009, 0.034) were lower in ovarian cystadenoma patients than in EOC patients and healthy women, respectively" -tissue_expression_down hsa-mir-92a Ovarian Neoplasms 30107086 "We report that miR-21 (P?=?0.0001), miR-100 (P?=?0.034), miR-200b (P?=?0.008), and miR-320 (P?=?0.034) are significantly enriched, whereas miR-16 (P?=?0.009), miR-93 (P?=?0.014), miR-126 (P?=?0.012), and miR-223 (P?=?0.029) are underrepresented in exosomes from plasma of EOC patients as compared to those of healthy women. The levels of exosomal miR-23a (P?=?0.009, 0.008) and miR-92a (P?=?009, 0.034) were lower in ovarian cystadenoma patients than in EOC patients and healthy women, respectively" -tissue_expression_down hsa-mir-93 Ovarian Neoplasms 30107086 "We report that miR-21 (P?=?0.0001), miR-100 (P?=?0.034), miR-200b (P?=?0.008), and miR-320 (P?=?0.034) are significantly enriched, whereas miR-16 (P?=?0.009), miR-93 (P?=?0.014), miR-126 (P?=?0.012), and miR-223 (P?=?0.029) are underrepresented in exosomes from plasma of EOC patients as compared to those of healthy women. The levels of exosomal miR-23a (P?=?0.009, 0.008) and miR-92a (P?=?009, 0.034) were lower in ovarian cystadenoma patients than in EOC patients and healthy women, respectively" -tissue_expression_down hsa-mir-1297 Colon Neoplasms 30127618 "seven miRNAs (hsa-miR-920, hsa-miR-636, hsa-miR-766-3p, hsa-miR-545-5p, hsa-miR-195-3p, hsa-miR-125a-3p, and hsa-miR-196b-3p) were found to be upregulated and six miRNAs (hsa-miR-3613-3p, hsa-miR-29b-3p, hsa-miR-1297, hsa-miR-141-5p, hsa-miR-200c-3p, and hsa-miR-141-3p) were found to be downregulated" -tissue_expression_down hsa-mir-141 Colon Neoplasms 30127618 "seven miRNAs (hsa-miR-920, hsa-miR-636, hsa-miR-766-3p, hsa-miR-545-5p, hsa-miR-195-3p, hsa-miR-125a-3p, and hsa-miR-196b-3p) were found to be upregulated and six miRNAs (hsa-miR-3613-3p, hsa-miR-29b-3p, hsa-miR-1297, hsa-miR-141-5p, hsa-miR-200c-3p, and hsa-miR-141-3p) were found to be downregulated" -tissue_expression_down hsa-mir-200c Colon Neoplasms 30127618 "seven miRNAs (hsa-miR-920, hsa-miR-636, hsa-miR-766-3p, hsa-miR-545-5p, hsa-miR-195-3p, hsa-miR-125a-3p, and hsa-miR-196b-3p) were found to be upregulated and six miRNAs (hsa-miR-3613-3p, hsa-miR-29b-3p, hsa-miR-1297, hsa-miR-141-5p, hsa-miR-200c-3p, and hsa-miR-141-3p) were found to be downregulated" -tissue_expression_down hsa-mir-29b Colon Neoplasms 30127618 "seven miRNAs (hsa-miR-920, hsa-miR-636, hsa-miR-766-3p, hsa-miR-545-5p, hsa-miR-195-3p, hsa-miR-125a-3p, and hsa-miR-196b-3p) were found to be upregulated and six miRNAs (hsa-miR-3613-3p, hsa-miR-29b-3p, hsa-miR-1297, hsa-miR-141-5p, hsa-miR-200c-3p, and hsa-miR-141-3p) were found to be downregulated" -tissue_expression_down hsa-mir-3613 Colon Neoplasms 30127618 "seven miRNAs (hsa-miR-920, hsa-miR-636, hsa-miR-766-3p, hsa-miR-545-5p, hsa-miR-195-3p, hsa-miR-125a-3p, and hsa-miR-196b-3p) were found to be upregulated and six miRNAs (hsa-miR-3613-3p, hsa-miR-29b-3p, hsa-miR-1297, hsa-miR-141-5p, hsa-miR-200c-3p, and hsa-miR-141-3p) were found to be downregulated" -tissue_expression_down hsa-mir-197 Uterine Leiomyoma 30149651 "The relative expression level of miR-15b was upregulated, and the relative expression levels of miR-29a, -29b, -29c, -197, and -200c were downregulated in UL cells compared to those in UM cells" -tissue_expression_down hsa-mir-200c Uterine Leiomyoma 30149651 "The relative expression level of miR-15b was upregulated, and the relative expression levels of miR-29a, -29b, -29c, -197, and -200c were downregulated in UL cells compared to those in UM cells" -tissue_expression_down hsa-mir-29a Uterine Leiomyoma 30149651 "The relative expression level of miR-15b was upregulated, and the relative expression levels of miR-29a, -29b, -29c, -197, and -200c were downregulated in UL cells compared to those in UM cells" -tissue_expression_down hsa-mir-29b Uterine Leiomyoma 30149651 "The relative expression level of miR-15b was upregulated, and the relative expression levels of miR-29a, -29b, -29c, -197, and -200c were downregulated in UL cells compared to those in UM cells" -tissue_expression_down hsa-mir-29c Uterine Leiomyoma 30149651 "The relative expression level of miR-15b was upregulated, and the relative expression levels of miR-29a, -29b, -29c, -197, and -200c were downregulated in UL cells compared to those in UM cells" -tissue_expression_down hsa-mir-199a Cholangiocarcinoma 30165035 "the hsa-miR-205-5p and miR-200 family members were markedly up-regulated for 600-1500 folds, whereas the miR-199 family members and their clustered miRNA, hsa-miR-214-3p, were down-regulated for 1000-2000 folds" -tissue_expression_down hsa-mir-199b Cholangiocarcinoma 30165035 "the hsa-miR-205-5p and miR-200 family members were markedly up-regulated for 600-1500 folds, whereas the miR-199 family members and their clustered miRNA, hsa-miR-214-3p, were down-regulated for 1000-2000 folds" -tissue_expression_down hsa-mir-214 Cholangiocarcinoma 30165035 "the hsa-miR-205-5p and miR-200 family members were markedly up-regulated for 600-1500 folds, whereas the miR-199 family members and their clustered miRNA, hsa-miR-214-3p, were down-regulated for 1000-2000 folds" -tissue_expression_down hsa-mir-124 Gastric Neoplasms 30171475 "The clinical significance of miR-335, miR-124, miR-218 and miR-484 downregulation in gastric cancer." -tissue_expression_down hsa-mir-218 Gastric Neoplasms 30171475 "The clinical significance of miR-335, miR-124, miR-218 and miR-484 downregulation in gastric cancer." -tissue_expression_down hsa-mir-335 Gastric Neoplasms 30171475 "The clinical significance of miR-335, miR-124, miR-218 and miR-484 downregulation in gastric cancer." -tissue_expression_down hsa-mir-484 Gastric Neoplasms 30171475 "The clinical significance of miR-335, miR-124, miR-218 and miR-484 downregulation in gastric cancer." -tissue_expression_down hsa-mir-548c Colorectal Carcinoma 30171732 Downregulation of exosome-encapsulated miR-548c-5p is associated with poor prognosis in colorectal cancer. -tissue_expression_down hsa-mir-192 Irritable Bowel Syndrome 30187701 MiRNAs play a pivotal role in visceral hypersensitivity and might be targets in the treatment of IBS by Tongxieyaofang -tissue_expression_down hsa-mir-221 Irritable Bowel Syndrome 30187701 MiRNAs play a pivotal role in visceral hypersensitivity and might be targets in the treatment of IBS by Tongxieyaofang -tissue_expression_down hsa-mir-223 Irritable Bowel Syndrome 30187701 MiRNAs play a pivotal role in visceral hypersensitivity and might be targets in the treatment of IBS by Tongxieyaofang -tissue_expression_down hsa-mir-24 Irritable Bowel Syndrome 30187701 MiRNAs play a pivotal role in visceral hypersensitivity and might be targets in the treatment of IBS by Tongxieyaofang -tissue_expression_down hsa-mir-31a Irritable Bowel Syndrome 30187701 MiRNAs play a pivotal role in visceral hypersensitivity and might be targets in the treatment of IBS by Tongxieyaofang -tissue_expression_down hsa-let-7b Carcinosarcoma 30200635 "In carcinosarcoma (CS), lower CSS was associated with the upregulation of miR-184, and the downregulation of let-7b-5p and miR-124" -tissue_expression_down hsa-let-7f Endometrial Stromal Sarcoma 30200635 "In endometrial stromal sarcomas (ESS), the upregulation of miR-373-3p, miR-372-3p, and let-7b-5p, and the down-expression of let-7f-5p, miR-23-3p, and let-7b-5p were associated with lower CSS" -tissue_expression_down hsa-mir-10a Leiomyosarcoma 30200635 "In leiomyosarcoma (LMS), there was an association of lower cancer-specific survival (CSS) with the downregulation of miR-125a-5p and miR-10a-5p, and the upregulation of miR-196a-5p and miR-34c-5p" -tissue_expression_down hsa-mir-124 Carcinosarcoma 30200635 "In carcinosarcoma (CS), lower CSS was associated with the upregulation of miR-184, and the downregulation of let-7b-5p and miR-124" -tissue_expression_down hsa-mir-125a Leiomyosarcoma 30200635 "In leiomyosarcoma (LMS), there was an association of lower cancer-specific survival (CSS) with the downregulation of miR-125a-5p and miR-10a-5p, and the upregulation of miR-196a-5p and miR-34c-5p" -tissue_expression_down hsa-mir-23 Endometrial Stromal Sarcoma 30200635 "In endometrial stromal sarcomas (ESS), the upregulation of miR-373-3p, miR-372-3p, and let-7b-5p, and the down-expression of let-7f-5p, miR-23-3p, and let-7b-5p were associated with lower CSS" -tissue_expression_down hsa-let-7a Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-let-7d Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-let-7f Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-let-7g Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-let-7i Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-103a Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-106b Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-128 Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-130a Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-130b Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-144 Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-148a Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-148b Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-151a Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-151b Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-15a Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-15b Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-16 Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-182 Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-183 Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-186 Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-22 Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-221 Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-223 Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-23a Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-26a Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-26b Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-27b Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-28 Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-30b Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-30c Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-342 Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-425 Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-451a Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-532 Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-550a Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-584 Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-93 Amyotrophic Lateral Sclerosis 30210287 Results showed that 38 miRNAs were significantly downregulated in sALS -tissue_expression_down hsa-mir-138 Thyroid Neoplasms 30210669 "We ultimately included five datasets, and further analyzed the four miRNAs that were down-regulated in at least four datasets (miR-7-2-3p, miR-138-5p, miR-144-5p, miR-486-5p)" -tissue_expression_down hsa-mir-144 Thyroid Neoplasms 30210669 "We ultimately included five datasets, and further analyzed the four miRNAs that were down-regulated in at least four datasets (miR-7-2-3p, miR-138-5p, miR-144-5p, miR-486-5p)" -tissue_expression_down hsa-mir-486 Thyroid Neoplasms 30210669 "We ultimately included five datasets, and further analyzed the four miRNAs that were down-regulated in at least four datasets (miR-7-2-3p, miR-138-5p, miR-144-5p, miR-486-5p)" -tissue_expression_down hsa-mir-7-2 Thyroid Neoplasms 30210669 "We ultimately included five datasets, and further analyzed the four miRNAs that were down-regulated in at least four datasets (miR-7-2-3p, miR-138-5p, miR-144-5p, miR-486-5p)" -tissue_expression_down hsa-mir-129 "Squamous Cell Carcinoma, Oral" 30210912 "The expression levels of miR-129-5p and miR-296-5p were significantly downregulated in OLK-OSCC tissues compared to OLK tissues, while miR-450b-5p levels were higher in OLK-OSCC tissues" -tissue_expression_down hsa-mir-296 "Squamous Cell Carcinoma, Oral" 30210912 "The expression levels of miR-129-5p and miR-296-5p were significantly downregulated in OLK-OSCC tissues compared to OLK tissues, while miR-450b-5p levels were higher in OLK-OSCC tissues" -tissue_expression_down hsa-mir-652 Neoplasms [unspecific] 30225717 "Bioinformatic analysis has detected microRNA potentially regulated by xenosensor receptors AhR (miR-28, miR-30c, miR-30e, miR-139, and miR-153) and CAR (miR-29c, miR-31, miR-185, miR-625, and miR-652)" -tissue_expression_down hsa-mir-1294 Gastric Neoplasms 30229824 Expression of miR-1294 is downregulated and predicts a poor prognosis in gastric cancer. -tissue_expression_down hsa-mir-543 Infertility 30231774 Endometrial miR-543 Is Downregulated During the Implantation Window in Women With Endometriosis-Related Infertility. -tissue_expression_down hsa-mir-10b "Carcinoma, Breast" 30250531 3 miRNAs were upregulated: Hsa-miR-21b; hsa-miR-29b; and hsa-miR-155; and 3 miRNAs were downregulated: Hsa-miR-10b; hsa-miR-125; and hsa-miR-145 -tissue_expression_down hsa-mir-125 "Carcinoma, Breast" 30250531 3 miRNAs were upregulated: Hsa-miR-21b; hsa-miR-29b; and hsa-miR-155; and 3 miRNAs were downregulated: Hsa-miR-10b; hsa-miR-125; and hsa-miR-145 -tissue_expression_down hsa-mir-145 "Carcinoma, Breast" 30250531 3 miRNAs were upregulated: Hsa-miR-21b; hsa-miR-29b; and hsa-miR-155; and 3 miRNAs were downregulated: Hsa-miR-10b; hsa-miR-125; and hsa-miR-145 -tissue_expression_down hsa-mir-10a "Carcinoma, Hepatocellular" 30254459 the expression of miR-10a-5p is downregulated and miR-484 is the most abundant miRNA in hepatic precancerous lesions -tissue_expression_down hsa-mir-145 "Carcinoma, Hepatocellular" 30272372 "The high?level expression of IGF2 mRNA and cyclin E1 mRNA was due to the low?level expression of hsa?miR?145?5p, hsa?miR?181a?5p, hsa?miR?199a?5p and hsa?miR?223a?3p, and hsa?miR?26a?5p and hsa?miR?26b?5p, respectively" -tissue_expression_down hsa-mir-181a "Carcinoma, Hepatocellular" 30272372 "The high?level expression of IGF2 mRNA and cyclin E1 mRNA was due to the low?level expression of hsa?miR?145?5p, hsa?miR?181a?5p, hsa?miR?199a?5p and hsa?miR?223a?3p, and hsa?miR?26a?5p and hsa?miR?26b?5p, respectively" -tissue_expression_down hsa-mir-199a "Carcinoma, Hepatocellular" 30272372 "The high?level expression of IGF2 mRNA and cyclin E1 mRNA was due to the low?level expression of hsa?miR?145?5p, hsa?miR?181a?5p, hsa?miR?199a?5p and hsa?miR?223a?3p, and hsa?miR?26a?5p and hsa?miR?26b?5p, respectively" -tissue_expression_down hsa-mir-223a "Carcinoma, Hepatocellular" 30272372 "The high?level expression of IGF2 mRNA and cyclin E1 mRNA was due to the low?level expression of hsa?miR?145?5p, hsa?miR?181a?5p, hsa?miR?199a?5p and hsa?miR?223a?3p, and hsa?miR?26a?5p and hsa?miR?26b?5p, respectively" -tissue_expression_down hsa-mir-26a "Carcinoma, Hepatocellular" 30272372 "The high?level expression of IGF2 mRNA and cyclin E1 mRNA was due to the low?level expression of hsa?miR?145?5p, hsa?miR?181a?5p, hsa?miR?199a?5p and hsa?miR?223a?3p, and hsa?miR?26a?5p and hsa?miR?26b?5p, respectively" -tissue_expression_down hsa-mir-26b "Carcinoma, Hepatocellular" 30272372 "The high?level expression of IGF2 mRNA and cyclin E1 mRNA was due to the low?level expression of hsa?miR?145?5p, hsa?miR?181a?5p, hsa?miR?199a?5p and hsa?miR?223a?3p, and hsa?miR?26a?5p and hsa?miR?26b?5p, respectively" -tissue_expression_down hsa-mir-221 "Carcinoma, Pancreatic" 30333874 "The results revealed that 2 upregulated miRNAs (miR-34a and -193a-3p) and 4 downregulated miRNAs (miR-221, -222, -484, and -502-3p) exhibited a consistent expression pattern between the PC-1.0/PC-1 and AsPC-1/CAPAN-2 pancreatic cancer cells" -tissue_expression_down hsa-mir-222 "Carcinoma, Pancreatic" 30333874 "The results revealed that 2 upregulated miRNAs (miR-34a and -193a-3p) and 4 downregulated miRNAs (miR-221, -222, -484, and -502-3p) exhibited a consistent expression pattern between the PC-1.0/PC-1 and AsPC-1/CAPAN-2 pancreatic cancer cells" -tissue_expression_down hsa-mir-484 "Carcinoma, Pancreatic" 30333874 "The results revealed that 2 upregulated miRNAs (miR-34a and -193a-3p) and 4 downregulated miRNAs (miR-221, -222, -484, and -502-3p) exhibited a consistent expression pattern between the PC-1.0/PC-1 and AsPC-1/CAPAN-2 pancreatic cancer cells" -tissue_expression_down hsa-mir-502 "Carcinoma, Pancreatic" 30333874 "The results revealed that 2 upregulated miRNAs (miR-34a and -193a-3p) and 4 downregulated miRNAs (miR-221, -222, -484, and -502-3p) exhibited a consistent expression pattern between the PC-1.0/PC-1 and AsPC-1/CAPAN-2 pancreatic cancer cells" -tissue_expression_down hsa-mir-138 "Carcinoma, Renal Cell" 30344735 "2 upregulated (hsa-miR-155-5p and hsa-miR-210-5p) and 6 downregulated (hsa-miR-138-5p, hsa-miR-141-5p, hsa-miR-200c-5p, hsa-miR-362-5p, hsa-miR-363-5p and hsa-miR-429) meta-signature miRNAs in renal carcinoma were identified" -tissue_expression_down hsa-mir-141 "Carcinoma, Renal Cell" 30344735 "2 upregulated (hsa-miR-155-5p and hsa-miR-210-5p) and 6 downregulated (hsa-miR-138-5p, hsa-miR-141-5p, hsa-miR-200c-5p, hsa-miR-362-5p, hsa-miR-363-5p and hsa-miR-429) meta-signature miRNAs in renal carcinoma were identified" -tissue_expression_down hsa-mir-200c "Carcinoma, Renal Cell" 30344735 "2 upregulated (hsa-miR-155-5p and hsa-miR-210-5p) and 6 downregulated (hsa-miR-138-5p, hsa-miR-141-5p, hsa-miR-200c-5p, hsa-miR-362-5p, hsa-miR-363-5p and hsa-miR-429) meta-signature miRNAs in renal carcinoma were identified" -tissue_expression_down hsa-mir-362 "Carcinoma, Renal Cell" 30344735 "2 upregulated (hsa-miR-155-5p and hsa-miR-210-5p) and 6 downregulated (hsa-miR-138-5p, hsa-miR-141-5p, hsa-miR-200c-5p, hsa-miR-362-5p, hsa-miR-363-5p and hsa-miR-429) meta-signature miRNAs in renal carcinoma were identified" -tissue_expression_down hsa-mir-363 "Carcinoma, Renal Cell" 30344735 "2 upregulated (hsa-miR-155-5p and hsa-miR-210-5p) and 6 downregulated (hsa-miR-138-5p, hsa-miR-141-5p, hsa-miR-200c-5p, hsa-miR-362-5p, hsa-miR-363-5p and hsa-miR-429) meta-signature miRNAs in renal carcinoma were identified" -tissue_expression_down hsa-mir-429 "Carcinoma, Renal Cell" 30344735 "2 upregulated (hsa-miR-155-5p and hsa-miR-210-5p) and 6 downregulated (hsa-miR-138-5p, hsa-miR-141-5p, hsa-miR-200c-5p, hsa-miR-362-5p, hsa-miR-363-5p and hsa-miR-429) meta-signature miRNAs in renal carcinoma were identified" -tissue_expression_down hsa-mir-30a Idiopathic Pulmonary Fibrosis 30365083 Downregulation of microRNA?30a in bronchoalveolar lavage fluid from idiopathic pulmonary fibrosis patients. -tissue_expression_down hsa-mir-200b Human Cytomegalovirus Infection 30366960 Low tissue levels of 200b-3p and 200c-3p in humans are associated with cytopathic inflammation due to HCMV infection -tissue_expression_down hsa-mir-200c Human Cytomegalovirus Infection 30366960 Low tissue levels of 200b-3p and 200c-3p in humans are associated with cytopathic inflammation due to HCMV infection -tissue_expression_down hsa-mir-1299 Rhinosinusitis 30378273 "Five upregulated miRNAs, including miR-210-5p, miR-3178, miR-585-3p, miR-3146, and miR-320e, and 19 downregulated miRNAs, including miR-32-3p, miR-1299, miR-3196, miR-3924, and miR-548e-3p, were differentially expressed (p < 0.05, fold change >2) in tissues of CRSwNP vs controls" -tissue_expression_down hsa-mir-3196 Rhinosinusitis 30378273 "Five upregulated miRNAs, including miR-210-5p, miR-3178, miR-585-3p, miR-3146, and miR-320e, and 19 downregulated miRNAs, including miR-32-3p, miR-1299, miR-3196, miR-3924, and miR-548e-3p, were differentially expressed (p < 0.05, fold change >2) in tissues of CRSwNP vs controls" -tissue_expression_down hsa-mir-32 Rhinosinusitis 30378273 "Five upregulated miRNAs, including miR-210-5p, miR-3178, miR-585-3p, miR-3146, and miR-320e, and 19 downregulated miRNAs, including miR-32-3p, miR-1299, miR-3196, miR-3924, and miR-548e-3p, were differentially expressed (p < 0.05, fold change >2) in tissues of CRSwNP vs controls" -tissue_expression_down hsa-mir-3924 Rhinosinusitis 30378273 "Five upregulated miRNAs, including miR-210-5p, miR-3178, miR-585-3p, miR-3146, and miR-320e, and 19 downregulated miRNAs, including miR-32-3p, miR-1299, miR-3196, miR-3924, and miR-548e-3p, were differentially expressed (p < 0.05, fold change >2) in tissues of CRSwNP vs controls" -tissue_expression_down hsa-mir-548e Rhinosinusitis 30378273 "Five upregulated miRNAs, including miR-210-5p, miR-3178, miR-585-3p, miR-3146, and miR-320e, and 19 downregulated miRNAs, including miR-32-3p, miR-1299, miR-3196, miR-3924, and miR-548e-3p, were differentially expressed (p < 0.05, fold change >2) in tissues of CRSwNP vs controls" -tissue_expression_down hsa-let-7c Neoplasms [unspecific] 30384176 Identification of key differentially expressed MicroRNAs in cancer patients through pan-cancer analysis(down). -tissue_expression_down hsa-mir-1-2 Neoplasms [unspecific] 30384176 Identification of key differentially expressed MicroRNAs in cancer patients through pan-cancer analysis(down). -tissue_expression_down hsa-mir-1247 Neoplasms [unspecific] 30384176 Identification of key differentially expressed MicroRNAs in cancer patients through pan-cancer analysis(down). -tissue_expression_down hsa-mir-133a-1 Neoplasms [unspecific] 30384176 Identification of key differentially expressed MicroRNAs in cancer patients through pan-cancer analysis(down). -tissue_expression_down hsa-mir-133a-2 Neoplasms [unspecific] 30384176 Identification of key differentially expressed MicroRNAs in cancer patients through pan-cancer analysis(down). -tissue_expression_down hsa-mir-133b Neoplasms [unspecific] 30384176 Identification of key differentially expressed MicroRNAs in cancer patients through pan-cancer analysis(down). -tissue_expression_down hsa-mir-139 Neoplasms [unspecific] 30384176 Identification of key differentially expressed MicroRNAs in cancer patients through pan-cancer analysis(down). -tissue_expression_down hsa-mir-145 Neoplasms [unspecific] 30384176 Identification of key differentially expressed MicroRNAs in cancer patients through pan-cancer analysis(down). -tissue_expression_down hsa-mir-195 Neoplasms [unspecific] 30384176 Identification of key differentially expressed MicroRNAs in cancer patients through pan-cancer analysis(down). -tissue_expression_down hsa-mir-204 Neoplasms [unspecific] 30384176 Identification of key differentially expressed MicroRNAs in cancer patients through pan-cancer analysis(down). -tissue_expression_down hsa-mir-206 Neoplasms [unspecific] 30384176 Identification of key differentially expressed MicroRNAs in cancer patients through pan-cancer analysis(down). -tissue_expression_down hsa-mir-99a Neoplasms [unspecific] 30384176 Identification of key differentially expressed MicroRNAs in cancer patients through pan-cancer analysis(down). -tissue_expression_ns hsa-mir-155 "Lymphoma, Burkitt" 16235244 Expression of BIC and miR-155 in 3 latency type III EBV-positive BL cell lines and in all primary PTLD cases suggests a possible role for EBV latency type III specific proteins in the induction of BIC expression. -tissue_expression_ns hsa-mir-133b "Carcinoma, Rectal" 16854228 "The analysis by several bioinformatics algorithms of colorectal tumours and adjacent non-neoplastic tissues from patients and colorectal cancer cell lines allowed identifying a group of 13 miRNA whose expression is significantly altered in this tumor. The most significantly deregulated miRNA being miR-31, miR-96, miR-133b, miR-135b, miR-145, and miR-183." -tissue_expression_ns hsa-mir-135b "Carcinoma, Rectal" 16854228 "The analysis by several bioinformatics algorithms of colorectal tumours and adjacent non-neoplastic tissues from patients and colorectal cancer cell lines allowed identifying a group of 13 miRNA whose expression is significantly altered in this tumor. The most significantly deregulated miRNA being miR-31, miR-96, miR-133b, miR-135b, miR-145, and miR-183." -tissue_expression_ns hsa-mir-145 "Carcinoma, Rectal" 16854228 "The analysis by several bioinformatics algorithms of colorectal tumours and adjacent non-neoplastic tissues from patients and colorectal cancer cell lines allowed identifying a group of 13 miRNA whose expression is significantly altered in this tumor. The most significantly deregulated miRNA being miR-31, miR-96, miR-133b, miR-135b, miR-145, and miR-183." -tissue_expression_ns hsa-mir-183 "Carcinoma, Rectal" 16854228 "The analysis by several bioinformatics algorithms of colorectal tumours and adjacent non-neoplastic tissues from patients and colorectal cancer cell lines allowed identifying a group of 13 miRNA whose expression is significantly altered in this tumor. The most significantly deregulated miRNA being miR-31, miR-96, miR-133b, miR-135b, miR-145, and miR-183." -tissue_expression_ns hsa-mir-31 "Carcinoma, Rectal" 16854228 "The analysis by several bioinformatics algorithms of colorectal tumours and adjacent non-neoplastic tissues from patients and colorectal cancer cell lines allowed identifying a group of 13 miRNA whose expression is significantly altered in this tumor. The most significantly deregulated miRNA being miR-31, miR-96, miR-133b, miR-135b, miR-145, and miR-183." -tissue_expression_ns hsa-mir-96 "Carcinoma, Rectal" 16854228 "The analysis by several bioinformatics algorithms of colorectal tumours and adjacent non-neoplastic tissues from patients and colorectal cancer cell lines allowed identifying a group of 13 miRNA whose expression is significantly altered in this tumor. The most significantly deregulated miRNA being miR-31, miR-96, miR-133b, miR-135b, miR-145, and miR-183." -tissue_expression_ns hsa-mir-146a Inflammation 16885212 Analysis of miR-146a and miR-146b gene expression unveiled a pattern of induction in response to a variety of microbial components and proinflammatory cytokines. -tissue_expression_ns hsa-mir-146b Inflammation 16885212 Analysis of miR-146a and miR-146b gene expression unveiled a pattern of induction in response to a variety of microbial components and proinflammatory cytokines. -tissue_expression_ns hsa-mir-103 Pancreatic Neoplasms 16966691 "the expression of miR-103 and miR-107, associated with lack of expression of miR-155, discriminates tumors from normal" -tissue_expression_ns hsa-mir-107 Pancreatic Neoplasms 16966691 "the expression of miR-103 and miR-107, associated with lack of expression of miR-155, discriminates tumors from normal" -tissue_expression_ns hsa-mir-155 Pancreatic Neoplasms 16966691 "the expression of miR-103 and miR-107, associated with lack of expression of miR-155, discriminates tumors from normal" -tissue_expression_ns hsa-mir-372 "Carcinoma, Embryonal" 17011485 "Expression of miR-372 and miR-373 seems to be specifically associated with germ cell tumors, as most somatic tumors do not express these miRNAs." -tissue_expression_ns hsa-mir-373 "Carcinoma, Embryonal" 17011485 "Expression of miR-372 and miR-373 seems to be specifically associated with germ cell tumors, as most somatic tumors do not express these miRNAs." -tissue_expression_ns hsa-mir-155 Pancreatic Neoplasms 17149698 "One hundred microRNA precursors were aberrantly expressed in pancreatic cancer or desmoplasia (p < 0.01), including microRNAs previously reported as differentially expressed in other human cancers (miR-155, miR-21, miR-221 and miR-222) as well as those not previously reported in cancer (miR-376a and miR-301)." -tissue_expression_ns hsa-mir-21 Pancreatic Neoplasms 17149698 "One hundred microRNA precursors were aberrantly expressed in pancreatic cancer or desmoplasia (p < 0.01), including microRNAs previously reported as differentially expressed in other human cancers (miR-155, miR-21, miR-221 and miR-222) as well as those not previously reported in cancer (miR-376a and miR-301)." -tissue_expression_ns hsa-mir-221 Pancreatic Neoplasms 17149698 "One hundred microRNA precursors were aberrantly expressed in pancreatic cancer or desmoplasia (p < 0.01), including microRNAs previously reported as differentially expressed in other human cancers (miR-155, miR-21, miR-221 and miR-222) as well as those not previously reported in cancer (miR-376a and miR-301)." -tissue_expression_ns hsa-mir-222 Pancreatic Neoplasms 17149698 "One hundred microRNA precursors were aberrantly expressed in pancreatic cancer or desmoplasia (p < 0.01), including microRNAs previously reported as differentially expressed in other human cancers (miR-155, miR-21, miR-221 and miR-222) as well as those not previously reported in cancer (miR-376a and miR-301)." -tissue_expression_ns hsa-mir-301 Pancreatic Neoplasms 17149698 "One hundred microRNA precursors were aberrantly expressed in pancreatic cancer or desmoplasia (p < 0.01), including microRNAs previously reported as differentially expressed in other human cancers (miR-155, miR-21, miR-221 and miR-222) as well as those not previously reported in cancer (miR-376a and miR-301)." -tissue_expression_ns hsa-mir-376a Pancreatic Neoplasms 17149698 "One hundred microRNA precursors were aberrantly expressed in pancreatic cancer or desmoplasia (p < 0.01), including microRNAs previously reported as differentially expressed in other human cancers (miR-155, miR-21, miR-221 and miR-222) as well as those not previously reported in cancer (miR-376a and miR-301)." -tissue_expression_ns hsa-mir-216 "Adenocarcinoma, Pancreatic Ductal" 17237814 The expression of miR-216 and -217 and lack of expression of miR-133a were identified as characteristic of pancreas tissue. -tissue_expression_ns hsa-mir-217 "Adenocarcinoma, Pancreatic Ductal" 17237814 The expression of miR-216 and -217 and lack of expression of miR-133a were identified as characteristic of pancreas tissue. -tissue_expression_ns hsa-mir-182 Preeclampsia 17346547 "Differential expression between preeclampsia and the control group (miR-210, miR-182) and between preeclampsia + SGA and the control group (miR-210, miR-182*, and others) was found." -tissue_expression_ns hsa-mir-210 Preeclampsia 17346547 "Differential expression between preeclampsia and the control group (miR-210, miR-182) and between preeclampsia + SGA and the control group (miR-210, miR-182*, and others) was found." -tissue_expression_ns hsa-let-7c Prostate Neoplasms 17891175 "We have analysed expression of 328 known and 152 novel human miRNAs in 10 benign peripheral zone tissues and 16 prostate cancer tissues using microarrays and found widespread, but not universal, downregulation of miRNAs in clinically localized prostate cancer relative to benign peripheral zone tissue.These findings have been verified by real-time RT-PCR assays on select miRNAs, including miR-125b, miR-145 and let-7c." -tissue_expression_ns hsa-mir-125b Prostate Neoplasms 17891175 "We have analysed expression of 328 known and 152 novel human miRNAs in 10 benign peripheral zone tissues and 16 prostate cancer tissues using microarrays and found widespread, but not universal, downregulation of miRNAs in clinically localized prostate cancer relative to benign peripheral zone tissue.These findings have been verified by real-time RT-PCR assays on select miRNAs, including miR-125b, miR-145 and let-7c." -tissue_expression_ns hsa-mir-145 Prostate Neoplasms 17891175 "We have analysed expression of 328 known and 152 novel human miRNAs in 10 benign peripheral zone tissues and 16 prostate cancer tissues using microarrays and found widespread, but not universal, downregulation of miRNAs in clinically localized prostate cancer relative to benign peripheral zone tissue.These findings have been verified by real-time RT-PCR assays on select miRNAs, including miR-125b, miR-145 and let-7c." -tissue_expression_ns hsa-mir-15a "Leukemia, Lymphocytic, Chronic, B-Cell" 17941951 altered expression -tissue_expression_ns hsa-mir-16-1 "Leukemia, Lymphocytic, Chronic, B-Cell" 17941951 altered expression -tissue_expression_ns hsa-mir-142 Ovarian Neoplasms 18182067 "We selected and validated the expression of miR-20a, miR-21, miR-26a, miR-18a, miR-206, miR-181a and miR-142-5p and found their differential expression in tissue and cell-specific manners (P<0.05)." -tissue_expression_ns hsa-mir-181a Ovarian Neoplasms 18182067 "We selected and validated the expression of miR-20a, miR-21, miR-26a, miR-18a, miR-206, miR-181a and miR-142-5p and found their differential expression in tissue and cell-specific manners (P<0.05)." -tissue_expression_ns hsa-mir-18a Ovarian Neoplasms 18182067 "We selected and validated the expression of miR-20a, miR-21, miR-26a, miR-18a, miR-206, miR-181a and miR-142-5p and found their differential expression in tissue and cell-specific manners (P<0.05)." -tissue_expression_ns hsa-mir-206 Ovarian Neoplasms 18182067 "We selected and validated the expression of miR-20a, miR-21, miR-26a, miR-18a, miR-206, miR-181a and miR-142-5p and found their differential expression in tissue and cell-specific manners (P<0.05)." -tissue_expression_ns hsa-mir-20a Ovarian Neoplasms 18182067 "We selected and validated the expression of miR-20a, miR-21, miR-26a, miR-18a, miR-206, miR-181a and miR-142-5p and found their differential expression in tissue and cell-specific manners (P<0.05)." -tissue_expression_ns hsa-mir-21 Ovarian Neoplasms 18182067 "We selected and validated the expression of miR-20a, miR-21, miR-26a, miR-18a, miR-206, miR-181a and miR-142-5p and found their differential expression in tissue and cell-specific manners (P<0.05)." -tissue_expression_ns hsa-mir-26a Ovarian Neoplasms 18182067 "We selected and validated the expression of miR-20a, miR-21, miR-26a, miR-18a, miR-206, miR-181a and miR-142-5p and found their differential expression in tissue and cell-specific manners (P<0.05)." -tissue_expression_ns hsa-let-7 Ovarian Neoplasms 18199536 "Here, we show that several miRNAs are altered in human ovarian cancer, with the most significantly deregulated miRNAs being miR-214, miR-199a*, miR-200a, miR-100, miR-125b, and let-7 cluster." -tissue_expression_ns hsa-mir-100 Ovarian Neoplasms 18199536 "Here, we show that several miRNAs are altered in human ovarian cancer, with the most significantly deregulated miRNAs being miR-214, miR-199a*, miR-200a, miR-100, miR-125b, and let-7 cluster." -tissue_expression_ns hsa-mir-125b Ovarian Neoplasms 18199536 "Here, we show that several miRNAs are altered in human ovarian cancer, with the most significantly deregulated miRNAs being miR-214, miR-199a*, miR-200a, miR-100, miR-125b, and let-7 cluster." -tissue_expression_ns hsa-mir-199a Ovarian Neoplasms 18199536 "Here, we show that several miRNAs are altered in human ovarian cancer, with the most significantly deregulated miRNAs being miR-214, miR-199a*, miR-200a, miR-100, miR-125b, and let-7 cluster." -tissue_expression_ns hsa-mir-200a Ovarian Neoplasms 18199536 "Here, we show that several miRNAs are altered in human ovarian cancer, with the most significantly deregulated miRNAs being miR-214, miR-199a*, miR-200a, miR-100, miR-125b, and let-7 cluster." -tissue_expression_ns hsa-mir-146 Inflammation 18291670 Recent evidence showing altered miRNA expression in chronic inflammatory diseases (e.g. miR-203 and miR-146) suggests their involvement in immune-mediated diseases. -tissue_expression_ns hsa-let-7b Melanoma 18477892 "The most significant discriminators were let-7b and miR-199a, and the expression of these miRNAs was validated by quantitative PCR." -tissue_expression_ns hsa-mir-199a Melanoma 18477892 "The most significant discriminators were let-7b and miR-199a, and the expression of these miRNAs was validated by quantitative PCR." -tissue_expression_ns hsa-mir-106a Autistic Disorder 18563458 miR-106a: deregulation -tissue_expression_ns hsa-mir-106b Autistic Disorder 18563458 miR-106b: deregulation -tissue_expression_ns hsa-mir-129-1 Autistic Disorder 18563458 miR-129: deregulation -tissue_expression_ns hsa-mir-129-2 Autistic Disorder 18563458 miR-129: deregulation -tissue_expression_ns hsa-mir-132 Autistic Disorder 18563458 miR-132: deregulation -tissue_expression_ns hsa-mir-140 Autistic Disorder 18563458 miR-140: deregulation -tissue_expression_ns hsa-mir-146b Autistic Disorder 18563458 miR-146b: deregulation -tissue_expression_ns hsa-mir-148b Autistic Disorder 18563458 miR-148b: deregulation -tissue_expression_ns hsa-mir-15a Autistic Disorder 18563458 miR-15a: deregulation -tissue_expression_ns hsa-mir-15b Autistic Disorder 18563458 miR-15b: deregulation -tissue_expression_ns hsa-mir-181d Autistic Disorder 18563458 miR-181d: deregulation -tissue_expression_ns hsa-mir-193b Autistic Disorder 18563458 miR-193b: deregulation -tissue_expression_ns hsa-mir-21 Autistic Disorder 18563458 miR-21: deregulation -tissue_expression_ns hsa-mir-212 Autistic Disorder 18563458 miR-212: deregulation -tissue_expression_ns hsa-mir-23a Autistic Disorder 18563458 miR-23a: deregulation -tissue_expression_ns hsa-mir-27a Autistic Disorder 18563458 miR-27a: deregulation -tissue_expression_ns hsa-mir-381 Autistic Disorder 18563458 miR-381: deregulation -tissue_expression_ns hsa-mir-431 Autistic Disorder 18563458 miR-431: deregulation -tissue_expression_ns hsa-mir-432 Autistic Disorder 18563458 miR-432: deregulation -tissue_expression_ns hsa-mir-484 Autistic Disorder 18563458 miR-484: deregulation -tissue_expression_ns hsa-mir-539 Autistic Disorder 18563458 miR-539: deregulation -tissue_expression_ns hsa-mir-550a-1 Autistic Disorder 18563458 miR-550: deregulation -tissue_expression_ns hsa-mir-550a-2 Autistic Disorder 18563458 miR-550: deregulation -tissue_expression_ns hsa-mir-598 Autistic Disorder 18563458 miR-598: deregulation -tissue_expression_ns hsa-mir-652 Autistic Disorder 18563458 miR-652: deregulation -tissue_expression_ns hsa-mir-7-1 Autistic Disorder 18563458 miR-7: deregulation -tissue_expression_ns hsa-mir-7-2 Autistic Disorder 18563458 miR-7: deregulation -tissue_expression_ns hsa-mir-7-3 Autistic Disorder 18563458 miR-7: deregulation -tissue_expression_ns hsa-mir-93 Autistic Disorder 18563458 miR-93: deregulation -tissue_expression_ns hsa-mir-95 Autistic Disorder 18563458 miR-95: deregulation -tissue_expression_ns hsa-mir-9-1 Brain Neoplasms 18624795 miR-9: Specifically Expressed in Brain Primary Tumors and Can Be Used to Differentiate Primary from Metastatic Brain Tumors -tissue_expression_ns hsa-mir-9-2 Brain Neoplasms 18624795 miR-9: Specifically Expressed in Brain Primary Tumors and Can Be Used to Differentiate Primary from Metastatic Brain Tumors -tissue_expression_ns hsa-mir-92b Brain Neoplasms 18624795 miR-92b: Specifically Expressed in Brain Primary Tumors and Can Be Used to Differentiate Primary from Metastatic Brain Tumors -tissue_expression_ns hsa-mir-9-3 Brain Neoplasms 18624795 miR-9: Specifically Expressed in Brain Primary Tumors and Can Be Used to Differentiate Primary from Metastatic Brain Tumors -tissue_expression_ns hsa-mir-196a-1 Pancreatic Neoplasms 18719196 "miR-196a: biomarkers improved the ability to distinguish between healthy tissue, PDAC, and chronic pancreatitis" -tissue_expression_ns hsa-mir-196a-2 Pancreatic Neoplasms 18719196 "miR-196a: biomarkers improved the ability to distinguish between healthy tissue, PDAC, and chronic pancreatitis" -tissue_expression_ns hsa-mir-217 Pancreatic Neoplasms 18719196 "miR-217: biomarkers improved the ability to distinguish between healthy tissue, PDAC, and chronic pancreatitis" -tissue_expression_ns hsa-mir-135a Prostate Neoplasms 18831788 "In addition, microRNA microarray data from other studies confirm that several predicted microRNAs, including miR-21, miR-135a, and miR-135b, demonstrate differential expression in prostate cancer cells, comparing with normal tissues." -tissue_expression_ns hsa-mir-135b Prostate Neoplasms 18831788 "In addition, microRNA microarray data from other studies confirm that several predicted microRNAs, including miR-21, miR-135a, and miR-135b, demonstrate differential expression in prostate cancer cells, comparing with normal tissues." -tissue_expression_ns hsa-mir-21 Prostate Neoplasms 18831788 "In addition, microRNA microarray data from other studies confirm that several predicted microRNAs, including miR-21, miR-135a, and miR-135b, demonstrate differential expression in prostate cancer cells, comparing with normal tissues." -tissue_expression_ns hsa-let-7a-1 Pituitary Adenoma 18840638 let-7a: deregulation -tissue_expression_ns hsa-let-7a-2 Pituitary Adenoma 18840638 let-7a: deregulation -tissue_expression_ns hsa-let-7a-3 Pituitary Adenoma 18840638 let-7a: deregulation -tissue_expression_ns hsa-mir-141 Pituitary Adenoma 18840638 miR-141: deregulation -tissue_expression_ns hsa-mir-143 Pituitary Adenoma 18840638 miR-143: deregulation -tissue_expression_ns hsa-mir-145 Pituitary Adenoma 18840638 miR-145: deregulation -tissue_expression_ns hsa-mir-150 Pituitary Adenoma 18840638 miR-150: deregulation -tissue_expression_ns hsa-mir-15a Pituitary Adenoma 18840638 miR-15a: deregulation -tissue_expression_ns hsa-mir-16-1 Pituitary Adenoma 18840638 miR-16: deregulation -tissue_expression_ns hsa-mir-16-2 Pituitary Adenoma 18840638 miR-16: deregulation -tissue_expression_ns hsa-mir-21 Pituitary Adenoma 18840638 miR-21: deregulation -tissue_expression_ns hsa-mir-10b Medulloblastoma 18973228 miR-10b: different expression in tumors overexpression or not ErbB2 -tissue_expression_ns hsa-mir-125b-1 Medulloblastoma 18973228 miR-125b: different expression in tumors overexpression or not ErbB2 -tissue_expression_ns hsa-mir-125b-2 Medulloblastoma 18973228 miR-125b: different expression in tumors overexpression or not ErbB2 -tissue_expression_ns hsa-mir-135a-1 Medulloblastoma 18973228 miR-135a: different expression in tumors overexpression or not ErbB2 -tissue_expression_ns hsa-mir-135a-2 Medulloblastoma 18973228 miR-135a: different expression in tumors overexpression or not ErbB2 -tissue_expression_ns hsa-mir-135b Medulloblastoma 18973228 miR-135b: different expression in tumors overexpression or not ErbB2 -tissue_expression_ns hsa-mir-153-1 Medulloblastoma 18973228 miR-153: different expression in tumors overexpression or not ErbB2 -tissue_expression_ns hsa-mir-153-2 Medulloblastoma 18973228 miR-153: different expression in tumors overexpression or not ErbB2 -tissue_expression_ns hsa-mir-181b-1 Medulloblastoma 18973228 miR-181b: different expression in tumors overexpression or not c-Myc -tissue_expression_ns hsa-mir-181b-2 Medulloblastoma 18973228 miR-181b: different expression in tumors overexpression or not c-Myc -tissue_expression_ns hsa-mir-199b Medulloblastoma 18973228 miR-199b: different expression in tumors overexpression or not ErbB2 -tissue_expression_ns hsa-mir-21 "Carcinoma, Hepatocellular" 19120703 "In some cases, aberrantly expressed miRNAs could be linked to cancer-associated pathways, indicating a direct role in liver tumourigenesis. For example, up-regulation of mir-221 and mir-21 could promote cell cycle progression, reduce cell death and favour angiogenesis and invasion." -tissue_expression_ns hsa-mir-221 "Carcinoma, Hepatocellular" 19120703 "In some cases, aberrantly expressed miRNAs could be linked to cancer-associated pathways, indicating a direct role in liver tumourigenesis. For example, up-regulation of mir-221 and mir-21 could promote cell cycle progression, reduce cell death and favour angiogenesis and invasion." -tissue_expression_ns hsa-mir-17 Azoospermia 19210773 miR-17: deregulation -tissue_expression_ns hsa-mir-18a Azoospermia 19210773 miR-18a: deregulation -tissue_expression_ns hsa-mir-19a Azoospermia 19210773 miR-19a: deregulation -tissue_expression_ns hsa-mir-19b-1 Azoospermia 19210773 miR-19b: deregulation -tissue_expression_ns hsa-mir-19b-2 Azoospermia 19210773 miR-19b: deregulation -tissue_expression_ns hsa-mir-20a Azoospermia 19210773 miR-20a: deregulation -tissue_expression_ns hsa-mir-302a Azoospermia 19210773 miR-302a: deregulation -tissue_expression_ns hsa-mir-371a Azoospermia 19210773 mir-371: deregulation -tissue_expression_ns hsa-mir-372 Azoospermia 19210773 mir-372: deregulation -tissue_expression_ns hsa-mir-373 Azoospermia 19210773 mir-373: deregulation -tissue_expression_ns hsa-mir-383 Azoospermia 19210773 miR-383: deregulation -tissue_expression_ns hsa-mir-491 Azoospermia 19210773 miR-491-3p: deregulation -tissue_expression_ns hsa-mir-520d Azoospermia 19210773 miR-520d-3p: deregulation -tissue_expression_ns hsa-mir-92a-1 Azoospermia 19210773 miR-92a: deregulation -tissue_expression_ns hsa-mir-92a-2 Azoospermia 19210773 miR-92a: deregulation -tissue_expression_ns hsa-mir-142 Leukemia 19246560 "Here, we report aberrant expression of hematopoietic-specific miR-223, miR-181a, miR-150, miR-142.3p, and miR-155 in HTLV-I-infected cells in vitro and uncultured ex vivo ATL cells." -tissue_expression_ns hsa-mir-150 Leukemia 19246560 "Here, we report aberrant expression of hematopoietic-specific miR-223, miR-181a, miR-150, miR-142.3p, and miR-155 in HTLV-I-infected cells in vitro and uncultured ex vivo ATL cells." -tissue_expression_ns hsa-mir-155 Leukemia 19246560 "Here, we report aberrant expression of hematopoietic-specific miR-223, miR-181a, miR-150, miR-142.3p, and miR-155 in HTLV-I-infected cells in vitro and uncultured ex vivo ATL cells." -tissue_expression_ns hsa-mir-181a Leukemia 19246560 "Here, we report aberrant expression of hematopoietic-specific miR-223, miR-181a, miR-150, miR-142.3p, and miR-155 in HTLV-I-infected cells in vitro and uncultured ex vivo ATL cells." -tissue_expression_ns hsa-mir-223 Leukemia 19246560 "Here, we report aberrant expression of hematopoietic-specific miR-223, miR-181a, miR-150, miR-142.3p, and miR-155 in HTLV-I-infected cells in vitro and uncultured ex vivo ATL cells." -tissue_expression_ns hsa-mir-152 Preeclampsia 19285651 miR-152: expressed differentially in preeclamptic placentas vs normal controls -tissue_expression_ns hsa-mir-210 Preeclampsia 19285651 miR-210: expressed differentially in preeclamptic placentas vs normal controls -tissue_expression_ns hsa-mir-411 Preeclampsia 19285651 miR-411: expressed differentially in preeclamptic placentas vs normal controls -tissue_expression_ns hsa-mir-127 "Lymphoma, Large B-Cell, Diffuse" 19287466 Specific expression of miR-17-5p and miR-127 in testicular and central nervous system diffuse large B-cell lymphoma. -tissue_expression_ns hsa-mir-17 "Lymphoma, Large B-Cell, Diffuse" 19287466 Specific expression of miR-17-5p and miR-127 in testicular and central nervous system diffuse large B-cell lymphoma. -tissue_expression_ns hsa-mir-196a-1 Barrett Esophagus 19342367 miR-196a: Marker of Progression -tissue_expression_ns hsa-mir-196a-2 Barrett Esophagus 19342367 miR-196a: Marker of Progression -tissue_expression_ns hsa-mir-106a "Carcinoma, Hepatocellular" 19360909 miR-106a: involve -tissue_expression_ns hsa-mir-17 "Carcinoma, Hepatocellular" 19360909 miR-17-5p: involve -tissue_expression_ns hsa-mir-20a "Carcinoma, Hepatocellular" 19360909 miR-20: involve -tissue_expression_ns hsa-mir-20b "Carcinoma, Hepatocellular" 19360909 miR-20: involve -tissue_expression_ns hsa-mir-92a-1 "Carcinoma, Hepatocellular" 19360909 miR-92: involve -tissue_expression_ns hsa-mir-92a-2 "Carcinoma, Hepatocellular" 19360909 miR-92: involve -tissue_expression_ns hsa-mir-92b "Carcinoma, Hepatocellular" 19360909 miR-92: involve -tissue_expression_ns hsa-mir-24 Kaposi Sarcoma 19381257 Mir-140 and Kaposi sarcoma-associated herpesvirus viral miRNAs increased linearly with the degree of transformation. Mir-24 emerged as a biomarker specific for KS. -tissue_expression_ns hsa-mir-126 Lung Neoplasms 19493678 "Comparing paired lung cancer tissue with adjacent normal lung parenchyma, hsa-miR-126*, hsa-miR-145, hsa-miR-21, hsa-miR-182, hsa-miR-183 and hsa-miR-210 were found to be the most differentially expressed miRNAs." -tissue_expression_ns hsa-mir-145 Lung Neoplasms 19493678 "Comparing paired lung cancer tissue with adjacent normal lung parenchyma, hsa-miR-126*, hsa-miR-145, hsa-miR-21, hsa-miR-182, hsa-miR-183 and hsa-miR-210 were found to be the most differentially expressed miRNAs." -tissue_expression_ns hsa-mir-182 Lung Neoplasms 19493678 "Comparing paired lung cancer tissue with adjacent normal lung parenchyma, hsa-miR-126*, hsa-miR-145, hsa-miR-21, hsa-miR-182, hsa-miR-183 and hsa-miR-210 were found to be the most differentially expressed miRNAs." -tissue_expression_ns hsa-mir-183 Lung Neoplasms 19493678 "Comparing paired lung cancer tissue with adjacent normal lung parenchyma, hsa-miR-126*, hsa-miR-145, hsa-miR-21, hsa-miR-182, hsa-miR-183 and hsa-miR-210 were found to be the most differentially expressed miRNAs." -tissue_expression_ns hsa-mir-21 Lung Neoplasms 19493678 "Comparing paired lung cancer tissue with adjacent normal lung parenchyma, hsa-miR-126*, hsa-miR-145, hsa-miR-21, hsa-miR-182, hsa-miR-183 and hsa-miR-210 were found to be the most differentially expressed miRNAs." -tissue_expression_ns hsa-mir-210 Lung Neoplasms 19493678 "Comparing paired lung cancer tissue with adjacent normal lung parenchyma, hsa-miR-126*, hsa-miR-145, hsa-miR-21, hsa-miR-182, hsa-miR-183 and hsa-miR-210 were found to be the most differentially expressed miRNAs." -tissue_expression_ns hsa-mir-21 "Adenocarcinoma, Colon" 19547998 "differential expression, with highest expression levels in SSAs; Levels of miR-181b but not miR-21 differed in HPs and normal mucosa; SSAs exhibited both significantly higher miR-181b levels and miR-21 levels; discriminating potential diagnostic value HP from SSA" -tissue_expression_ns hsa-mir-21 Myocardial Infarction 19706597 "hsa-mir-21:a remarkable example of MicroRNA expression signature; downregulated in infarcted areas, upregulated in border areas" -tissue_expression_ns hsa-mir-17 Glioblastoma 19775293 "Taken together, our results support an important role of altered miRNA expression in gliomas, and suggest miR-17 and miR-184 as interesting candidates contributing to glioma progression." -tissue_expression_ns hsa-mir-184 Glioblastoma 19775293 "Taken together, our results support an important role of altered miRNA expression in gliomas, and suggest miR-17 and miR-184 as interesting candidates contributing to glioma progression." -tissue_expression_ns hsa-mir-34c Ovarian Neoplasms 19798417 High grade serous carcinomas as a group exhibit significant miRNA dysregulation in comparison to tubal epithelium and the levels of miR-34c and miR-422b appear to be prognostically important. -tissue_expression_ns hsa-mir-422b Ovarian Neoplasms 19798417 High grade serous carcinomas as a group exhibit significant miRNA dysregulation in comparison to tubal epithelium and the levels of miR-34c and miR-422b appear to be prognostically important. -tissue_expression_ns hsa-mir-141 Bladder Neoplasms 19945312 "The diagnostic test, based on the three most discriminatory miRNAs in our panel (miR-200c, miR-141, and miR-30b), showed a sensitivity of 100% and a specificity of 96.2%. Such a panel of miRNAs has the potential to identify invasive bladder tumors misclassified in pathologic assessment of bladder biopsy specimens." -tissue_expression_ns hsa-mir-200c Bladder Neoplasms 19945312 "The diagnostic test, based on the three most discriminatory miRNAs in our panel (miR-200c, miR-141, and miR-30b), showed a sensitivity of 100% and a specificity of 96.2%. Such a panel of miRNAs has the potential to identify invasive bladder tumors misclassified in pathologic assessment of bladder biopsy specimens." -tissue_expression_ns hsa-mir-30b Bladder Neoplasms 19945312 "The diagnostic test, based on the three most discriminatory miRNAs in our panel (miR-200c, miR-141, and miR-30b), showed a sensitivity of 100% and a specificity of 96.2%. Such a panel of miRNAs has the potential to identify invasive bladder tumors misclassified in pathologic assessment of bladder biopsy specimens." -tissue_expression_ns hsa-mir-141 Prostate Neoplasms 20014922 "Promising molecular markers identified from gene expression profiling studies include AMACR, EZH2, TMPRSS2-ERG, miR-221 and miR-141, which are described in more detail." -tissue_expression_ns hsa-mir-221 Prostate Neoplasms 20014922 "Promising molecular markers identified from gene expression profiling studies include AMACR, EZH2, TMPRSS2-ERG, miR-221 and miR-141, which are described in more detail." -tissue_expression_ns hsa-mir-1 Cardiomegaly 20015039 "Lately, some highlight articles revealed that the altered expression of miRNAs such as miR-1, miR-133, miR-21, miR-208 etc in hearts also contributed to cardiovascular diseases, such as heart ischemia, cardiac hypertrophy, and arrhythmias." -tissue_expression_ns hsa-mir-133 Vascular Hypertrophy 20015039 "Lately, some highlight articles revealed that the altered expression of miRNAs such as miR-1, miR-133, miR-21, miR-208 etc in hearts also contributed to cardiovascular diseases, such as heart ischemia, cardiac hypertrophy, and arrhythmias." -tissue_expression_ns hsa-mir-208 Vascular Hypertrophy 20015039 "Lately, some highlight articles revealed that the altered expression of miRNAs such as miR-1, miR-133, miR-21, miR-208 etc in hearts also contributed to cardiovascular diseases, such as heart ischemia, cardiac hypertrophy, and arrhythmias." -tissue_expression_ns hsa-mir-21 Cardiomegaly 20015039 "Lately, some highlight articles revealed that the altered expression of miRNAs such as miR-1, miR-133, miR-21, miR-208 etc in hearts also contributed to cardiovascular diseases, such as heart ischemia, cardiac hypertrophy, and arrhythmias." -tissue_expression_ns hsa-mir-143 Neoplasms [unspecific] 20064147 "Overall, the current study suggests that miR-143 is ubiquitously expressed among tissues and is likely to be involved in the regulation of cell proliferation and apoptosis." -tissue_expression_ns hsa-mir-133b Myocardial Infarction 20075508 dysregulation -tissue_expression_ns hsa-mir-150 Myocardial Infarction 20075508 dysregulation -tissue_expression_ns hsa-mir-186 Myocardial Infarction 20075508 dysregulation -tissue_expression_ns hsa-mir-210 Myocardial Infarction 20075508 dysregulation -tissue_expression_ns hsa-mir-451a Myocardial Infarction 20075508 dysregulation -tissue_expression_ns hsa-mir-10a Breast Neoplasms 20099276 "miR-10a:dysregulated miRNAs were miR-146a, miR-10a, miR-221/222, miR-345, miR-200b and miR-200c" -tissue_expression_ns hsa-mir-146a Breast Neoplasms 20099276 "miR-146a:dysregulated miRNAs were miR-146a, miR-10a, miR-221/222, miR-345, miR-200b and miR-200c" -tissue_expression_ns hsa-mir-200b Breast Neoplasms 20099276 "miR-200b:dysregulated miRNAs were miR-146a, miR-10a, miR-221/222, miR-345, miR-200b and miR-200c" -tissue_expression_ns hsa-mir-200c Breast Neoplasms 20099276 "miR-200c:dysregulated miRNAs were miR-146a, miR-10a, miR-221/222, miR-345, miR-200b and miR-200c" -tissue_expression_ns hsa-mir-221 Breast Neoplasms 20099276 "miR-221:dysregulated miRNAs were miR-146a, miR-10a, miR-221/222, miR-345, miR-200b and miR-200c" -tissue_expression_ns hsa-mir-222 Breast Neoplasms 20099276 "miR-222:dysregulated miRNAs were miR-146a, miR-10a, miR-221/222, miR-345, miR-200b and miR-200c" -tissue_expression_ns hsa-mir-345 Breast Neoplasms 20099276 "miR-345:dysregulated miRNAs were miR-146a, miR-10a, miR-221/222, miR-345, miR-200b and miR-200c" -tissue_expression_ns hsa-mir-221 "Leukemia, Myelogenous, Chronic, BCR-ABL Positive" 20299489 "Among them, the expression of miR-34a, miR-221, and miR-222 was induced in the early stages and maintained throughout the late stages of differentiation." -tissue_expression_ns hsa-mir-222 "Leukemia, Myelogenous, Chronic, BCR-ABL Positive" 20299489 "Among them, the expression of miR-34a, miR-221, and miR-222 was induced in the early stages and maintained throughout the late stages of differentiation." -tissue_expression_ns hsa-mir-34a "Leukemia, Myelogenous, Chronic, BCR-ABL Positive" 20299489 "Among them, the expression of miR-34a, miR-221, and miR-222 was induced in the early stages and maintained throughout the late stages of differentiation." -tissue_expression_ns hsa-mir-204 Melanoma 20302635 "Although the number of cases is small, positive lymph node status in the two age groups was characterized by the statistically significant expression of hsa-miR-30a* and hsa-miR-204 (F-test, p-value < 0.001)." -tissue_expression_ns hsa-mir-30a Melanoma 20302635 "Although the number of cases is small, positive lymph node status in the two age groups was characterized by the statistically significant expression of hsa-miR-30a* and hsa-miR-204 (F-test, p-value < 0.001)." -tissue_expression_ns hsa-mir-16 Breast Adenocarcinoma 20433153 "Using isolated total RNA from human breast adenocarcinoma MCF-7 cells, the assay detected specifically miR-21 and miR-16 in parallel, and higher expression of oncogene miR-21 compared to miR-16 was demonstrated." -tissue_expression_ns hsa-mir-21 Breast Adenocarcinoma 20433153 "Using isolated total RNA from human breast adenocarcinoma MCF-7 cells, the assay detected specifically miR-21 and miR-16 in parallel, and higher expression of oncogene miR-21 compared to miR-16 was demonstrated." -tissue_expression_ns hsa-mir-146b "Carcinoma, Thyroid, Papillary" 20459574 Hyalinizing trabecular tumour of the thyroid-differential expression of distinct miRNAs compared with papillary thyroid carcinoma. -tissue_expression_ns hsa-mir-182 Glioma 20472885 miR-182 as a prognostic marker for glioma progression and patient survival. -tissue_expression_ns hsa-mir-200a Neoplasms [unspecific] 20498632 miR-200a:altered microRNA signatures as potent markers for ATCs -tissue_expression_ns hsa-mir-200b Neoplasms [unspecific] 20498632 miR-200b:altered microRNA signatures as potent markers for ATCs -tissue_expression_ns hsa-mir-200c Neoplasms [unspecific] 20498632 miR-200c:altered microRNA signatures as potent markers for ATCs -tissue_expression_ns hsa-mir-21 Neoplasms [unspecific] 20498632 miR-21:altered microRNA signatures as potent markers for ATCs -tissue_expression_ns hsa-mir-30a Neoplasms [unspecific] 20498632 miR-30:altered microRNA signatures as potent markers for ATCs -tissue_expression_ns hsa-mir-92a-1 "Carcinoma, Hepatocellular" 20518884 miR-92a:Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development -tissue_expression_ns hsa-mir-92a-2 "Carcinoma, Hepatocellular" 20518884 miR-92a:Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development -tissue_expression_ns hsa-mir-101 Prostate Neoplasms 20539944 "The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa." -tissue_expression_ns hsa-mir-125b Prostate Neoplasms 20539944 "The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa." -tissue_expression_ns hsa-mir-126 Prostate Neoplasms 20539944 "The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa." -tissue_expression_ns hsa-mir-141 Prostate Neoplasms 20539944 "The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa." -tissue_expression_ns hsa-mir-146a Prostate Neoplasms 20539944 "The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa." -tissue_expression_ns hsa-mir-200a Prostate Neoplasms 20539944 "The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa." -tissue_expression_ns hsa-mir-200b Prostate Neoplasms 20539944 "The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa." -tissue_expression_ns hsa-mir-200c Prostate Neoplasms 20539944 "The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa." -tissue_expression_ns hsa-mir-21 Prostate Neoplasms 20539944 "The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa." -tissue_expression_ns hsa-mir-221 Prostate Neoplasms 20539944 "The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa." -tissue_expression_ns hsa-mir-222 Prostate Neoplasms 20539944 "The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa." -tissue_expression_ns hsa-mir-330 Prostate Neoplasms 20539944 "The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa." -tissue_expression_ns hsa-mir-34 Prostate Neoplasms 20539944 "The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa." -tissue_expression_ns hsa-mir-429 Prostate Neoplasms 20539944 "The aim of this review is to describe the mechanisms of several known miRNAs, summarize recent studies on the relevance of altered expression of oncogenic miRNAs (e.g. miR-221/-222, miR-21, and miR-125b) and tumor suppressor miRNAs (e.g. miR-101, miR-126*, miR-146a, miR-330, miR-34 cluster, and miR-200 family) for PCa." -tissue_expression_ns hsa-mir-15b Inflammation 20564181 "Of note, differentially expressed miRNAs (hsa-miR-15b and 181b) may have a potential role in regulating these processes." -tissue_expression_ns hsa-mir-181b Inflammation 20564181 "Of note, differentially expressed miRNAs (hsa-miR-15b and 181b) may have a potential role in regulating these processes." -tissue_expression_ns hsa-mir-10a "Squamous Cell Carcinoma, Esophageal" 20588024 "We found that miR-205 and miR-10a were significantly altered in cellular expression, and might be specific for ESCC with potential roles in the pathogenesis. " -tissue_expression_ns hsa-mir-205 "Squamous Cell Carcinoma, Esophageal" 20588024 "We found that miR-205 and miR-10a were significantly altered in cellular expression, and might be specific for ESCC with potential roles in the pathogenesis. " -tissue_expression_ns hsa-mir-130a "Carcinoma, Lung, Non-Small-Cell" 20625274 Multivariate Cox regression analysis showed that miRNA-130a was an independent prognostic factor for patients with NSCLC. -tissue_expression_ns hsa-mir-106a "Carcinoma, Esophageal" 20628822 "Furthermore, miR-106a and miR-148a expression correlates with disease recurrence and tumor-related mortality." -tissue_expression_ns hsa-mir-148a "Carcinoma, Esophageal" 20628822 "Furthermore, miR-106a and miR-148a expression correlates with disease recurrence and tumor-related mortality." -tissue_expression_ns hsa-mir-205 "Carcinoma, Esophageal" 20628822 "The expression of miR-21, miR-106a, miR-148a, miR-205 in formalin-fixed paraffin-embedded specimens was evaluated by TaqMan qPCR assays. Expression was compared with clinicopathological features of the cancers and outcome." -tissue_expression_ns hsa-mir-21 "Carcinoma, Esophageal" 20628822 "The expression of miR-21, miR-106a, miR-148a, miR-205 in formalin-fixed paraffin-embedded specimens was evaluated by TaqMan qPCR assays. Expression was compared with clinicopathological features of the cancers and outcome." -tissue_expression_ns hsa-mir-146a Ischemia-Reperfusion Injury 20651252 "miR-146a:nine miRNAs (miR-21, miR-20a,miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805, and miR-194) that are differentially expressed following IRI" -tissue_expression_ns hsa-mir-187 Ischemia-Reperfusion Injury 20651252 "miR-187:nine miRNAs (miR-21, miR-20a,miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805, and miR-194) that are differentially expressed following IRI" -tissue_expression_ns hsa-mir-192 Ischemia-Reperfusion Injury 20651252 "miR-192:nine miRNAs (miR-21, miR-20a,miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805, and miR-194) that are differentially expressed following IRI" -tissue_expression_ns hsa-mir-194-1 Ischemia-Reperfusion Injury 20651252 "miR-194:nine miRNAs (miR-21, miR-20a,miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805, and miR-194) that are differentially expressed following IRI" -tissue_expression_ns hsa-mir-194-2 Ischemia-Reperfusion Injury 20651252 "miR-194:nine miRNAs (miR-21, miR-20a,miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805, and miR-194) that are differentially expressed following IRI" -tissue_expression_ns hsa-mir-199a-1 Ischemia-Reperfusion Injury 20651252 "miR-199a-3p:nine miRNAs (miR-21, miR-20a,miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805, and miR-194) that are differentially expressed following IRI" -tissue_expression_ns hsa-mir-199a-2 Ischemia-Reperfusion Injury 20651252 "miR-199a-3p:nine miRNAs (miR-21, miR-20a,miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805, and miR-194) that are differentially expressed following IRI" -tissue_expression_ns hsa-mir-20a Ischemia-Reperfusion Injury 20651252 "miR-20a:nine miRNAs (miR-21, miR-20a,miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805, and miR-194) that are differentially expressed following IRI" -tissue_expression_ns hsa-mir-21 Ischemia-Reperfusion Injury 20651252 "miR-21:nine miRNAs (miR-21, miR-20a,miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805, and miR-194) that are differentially expressed following IRI" -tissue_expression_ns hsa-mir-214 Ischemia-Reperfusion Injury 20651252 "miR-214:nine miRNAs (miR-21, miR-20a,miR-146a, miR-199a-3p, miR-214, miR-192, miR-187, miR-805, and miR-194) that are differentially expressed following IRI" -tissue_expression_ns hsa-mir-203 Choriocarcinoma 20652642 miR-203 expression is a new prognostic marker in pancreatic adenocarcinoma patients. -tissue_expression_ns hsa-mir-125b Ovarian Neoplasms 20658525 Our results suggest that aberrantly expressed miR-125b may contribute to OC development. -tissue_expression_ns hsa-mir-155 Breast Neoplasms 20664596 "miR-155:miR-155, is differentially expressed in ER- versus ER+ tumors" -tissue_expression_ns hsa-mir-29a Breast Neoplasms 20664596 "miR-29a:We identified a set of 13 miRNAs of which expression differed between IBC and non-IBC, making these miRNAs candidate markers for the IBC subtype" -tissue_expression_ns hsa-mir-30b Breast Neoplasms 20664596 "miR-30b:We identified a set of 13 miRNAs of which expression differed between IBC and non-IBC, making these miRNAs candidate markers for the IBC subtype" -tissue_expression_ns hsa-mir-342 Breast Neoplasms 20664596 "miR-342-3p:We identified a set of 13 miRNAs of which expression differed between IBC and non-IBC, making these miRNAs candidate markers for the IBC subtype" -tissue_expression_ns hsa-mir-520a Breast Neoplasms 20664596 "miR-520a-5p:We identified a set of 13 miRNAs of which expression differed between IBC and non-IBC, making these miRNAs candidate markers for the IBC subtype" -tissue_expression_ns hsa-mir-126 Immune System Disease [unspecific] 20682703 "Although altered expressions of miR-21 and miR-34a were manifested within cancer cells, those of miR-126 and miR-155 were predominantly confined to endothelial cells and immune cells, respectively." -tissue_expression_ns hsa-mir-155 Immune System Disease [unspecific] 20682703 "Although altered expressions of miR-21 and miR-34a were manifested within cancer cells, those of miR-126 and miR-155 were predominantly confined to endothelial cells and immune cells, respectively." -tissue_expression_ns hsa-mir-21 "Carcinoma, Rectal" 20682703 "Although altered expressions of miR-21 and miR-34a were manifested within cancer cells, those of miR-126 and miR-155 were predominantly confined to endothelial cells and immune cells, respectively." -tissue_expression_ns hsa-mir-34a "Carcinoma, Rectal" 20682703 "Although altered expressions of miR-21 and miR-34a were manifested within cancer cells, those of miR-126 and miR-155 were predominantly confined to endothelial cells and immune cells, respectively." -tissue_expression_ns hsa-mir-103a-1 Gastric Neoplasms 20726036 "miR-103, miR-21, miR-145, miR-106b, miR-146a, and miR-148a separated node-positive from node-negative gastric cancers" -tissue_expression_ns hsa-mir-103a-2 Gastric Neoplasms 20726036 "miR-103, miR-21, miR-145, miR-106b, miR-146a, and miR-148a separated node-positive from node-negative gastric cancers" -tissue_expression_ns hsa-mir-106b Gastric Neoplasms 20726036 "miR-103, miR-21, miR-145, miR-106b, miR-146a, and miR-148a separated node-positive from node-negative gastric cancers" -tissue_expression_ns hsa-mir-145 Gastric Neoplasms 20726036 "miR-103, miR-21, miR-145, miR-106b, miR-146a, and miR-148a separated node-positive from node-negative gastric cancers" -tissue_expression_ns hsa-mir-146a Gastric Neoplasms 20726036 "miR-103, miR-21, miR-145, miR-106b, miR-146a, and miR-148a separated node-positive from node-negative gastric cancers" -tissue_expression_ns hsa-mir-148a Gastric Neoplasms 20726036 "miR-103, miR-21, miR-145, miR-106b, miR-146a, and miR-148a separated node-positive from node-negative gastric cancers" -tissue_expression_ns hsa-mir-21 Gastric Neoplasms 20726036 "miR-103, miR-21, miR-145, miR-106b, miR-146a, and miR-148a separated node-positive from node-negative gastric cancers" -tissue_expression_ns hsa-let-7g Lung Neoplasms 20818338 "Four miRNAs (miR-155, miR-25, miR-495 and miR-7g) were expressed differently among these tumors. miR-155 was upregulated only in EGFR/KRAS-negative group, miR-25 was upregulated only in EGFR-positive group and miR-495 was upregulated only in KRAS-positive adenocarcinomas. " -tissue_expression_ns hsa-mir-155 Lung Neoplasms 20818338 "Four miRNAs (miR-155, miR-25, miR-495 and miR-7g) were expressed differently among these tumors. miR-155 was upregulated only in EGFR/KRAS-negative group, miR-25 was upregulated only in EGFR-positive group and miR-495 was upregulated only in KRAS-positive adenocarcinomas. " -tissue_expression_ns hsa-mir-25 Lung Neoplasms 20818338 "Four miRNAs (miR-155, miR-25, miR-495 and miR-7g) were expressed differently among these tumors. miR-155 was upregulated only in EGFR/KRAS-negative group, miR-25 was upregulated only in EGFR-positive group and miR-495 was upregulated only in KRAS-positive adenocarcinomas. " -tissue_expression_ns hsa-mir-495 Lung Neoplasms 20818338 "Four miRNAs (miR-155, miR-25, miR-495 and miR-7g) were expressed differently among these tumors. miR-155 was upregulated only in EGFR/KRAS-negative group, miR-25 was upregulated only in EGFR-positive group and miR-495 was upregulated only in KRAS-positive adenocarcinomas. " -tissue_expression_ns hsa-mir-31 Inflammatory Bowel Diseases 20848542 Dynamic changes in the expression of MicroRNA-31 during inflammatory bowel disease-associated neoplastic transformation. -tissue_expression_ns hsa-let-7d Prostate Neoplasms 20873592 "The expression profiles of the microRNAs let-7d, let-7g, miR-98, miR-96, miR-182 and miR-183 reflect the biological behavior of PCa to some extent, and might be important biomarkers for the early detection and prognostic assessment of prostate cancer." -tissue_expression_ns hsa-let-7g Prostate Neoplasms 20873592 "The expression profiles of the microRNAs let-7d, let-7g, miR-98, miR-96, miR-182 and miR-183 reflect the biological behavior of PCa to some extent, and might be important biomarkers for the early detection and prognostic assessment of prostate cancer." -tissue_expression_ns hsa-mir-182 Prostate Neoplasms 20873592 "The expression profiles of the microRNAs let-7d, let-7g, miR-98, miR-96, miR-182 and miR-183 reflect the biological behavior of PCa to some extent, and might be important biomarkers for the early detection and prognostic assessment of prostate cancer." -tissue_expression_ns hsa-mir-183 Prostate Neoplasms 20873592 "The expression profiles of the microRNAs let-7d, let-7g, miR-98, miR-96, miR-182 and miR-183 reflect the biological behavior of PCa to some extent, and might be important biomarkers for the early detection and prognostic assessment of prostate cancer." -tissue_expression_ns hsa-mir-96 Prostate Neoplasms 20873592 "The expression profiles of the microRNAs let-7d, let-7g, miR-98, miR-96, miR-182 and miR-183 reflect the biological behavior of PCa to some extent, and might be important biomarkers for the early detection and prognostic assessment of prostate cancer." -tissue_expression_ns hsa-mir-98 Prostate Neoplasms 20873592 "The expression profiles of the microRNAs let-7d, let-7g, miR-98, miR-96, miR-182 and miR-183 reflect the biological behavior of PCa to some extent, and might be important biomarkers for the early detection and prognostic assessment of prostate cancer." -tissue_expression_ns hsa-mir-210 Lung Neoplasms 20885442 These observations help explain contradictory data regarding miR-210 expression and its putative function in solid tumors. -tissue_expression_ns hsa-mir-125b Prostate Neoplasms 20890088 "Normalization of the four miRNAs hsa-miR-96, hsa- miR-125b, hsa-miR-205, and hsa-miR-375, which were previously shown to be regulated, shows that normalization to hsa-mir-16 can lead to biased results." -tissue_expression_ns hsa-mir-16 Prostate Neoplasms 20890088 "Normalization of the four miRNAs hsa-miR-96, hsa- miR-125b, hsa-miR-205, and hsa-miR-375, which were previously shown to be regulated, shows that normalization to hsa-mir-16 can lead to biased results." -tissue_expression_ns hsa-mir-205 Prostate Neoplasms 20890088 "Normalization of the four miRNAs hsa-miR-96, hsa- miR-125b, hsa-miR-205, and hsa-miR-375, which were previously shown to be regulated, shows that normalization to hsa-mir-16 can lead to biased results." -tissue_expression_ns hsa-mir-375 Prostate Neoplasms 20890088 "Normalization of the four miRNAs hsa-miR-96, hsa- miR-125b, hsa-miR-205, and hsa-miR-375, which were previously shown to be regulated, shows that normalization to hsa-mir-16 can lead to biased results." -tissue_expression_ns hsa-mir-96 Prostate Neoplasms 20890088 "Normalization of the four miRNAs hsa-miR-96, hsa- miR-125b, hsa-miR-205, and hsa-miR-375, which were previously shown to be regulated, shows that normalization to hsa-mir-16 can lead to biased results." -tissue_expression_ns hsa-let-7a Prostate Neoplasms 20944140 "The aim of our study was to assess the expression of mir-20a, let-7a, miR-15a and miR-16 in prostate cancer (PCa) and benign prostatic hyperplasia (BPH) tissue and to investigate the relation between the expression of miRNAs and the clinicopathological features of PCa." -tissue_expression_ns hsa-mir-15a Prostate Neoplasms 20944140 "The aim of our study was to assess the expression of mir-20a, let-7a, miR-15a and miR-16 in prostate cancer (PCa) and benign prostatic hyperplasia (BPH) tissue and to investigate the relation between the expression of miRNAs and the clinicopathological features of PCa." -tissue_expression_ns hsa-mir-16 Prostate Neoplasms 20944140 "The aim of our study was to assess the expression of mir-20a, let-7a, miR-15a and miR-16 in prostate cancer (PCa) and benign prostatic hyperplasia (BPH) tissue and to investigate the relation between the expression of miRNAs and the clinicopathological features of PCa." -tissue_expression_ns hsa-mir-20a Prostate Neoplasms 20944140 "The aim of our study was to assess the expression of mir-20a, let-7a, miR-15a and miR-16 in prostate cancer (PCa) and benign prostatic hyperplasia (BPH) tissue and to investigate the relation between the expression of miRNAs and the clinicopathological features of PCa." -tissue_expression_ns hsa-let-7a "Carcinoma, Lung, Non-Small-Cell" 20975375 "In an exploratory study, we determined whether expression of six miRNAs (let-7a, miR-7, miR-21, miR-155, miR-210, and miR-221) previously reported to correlate with invasiveness or outcome in various human malignancies were associated with tumor recurrence in patients with resected stage I NSCLC." -tissue_expression_ns hsa-mir-155 "Carcinoma, Lung, Non-Small-Cell" 20975375 "In an exploratory study, we determined whether expression of six miRNAs (let-7a, miR-7, miR-21, miR-155, miR-210, and miR-221) previously reported to correlate with invasiveness or outcome in various human malignancies were associated with tumor recurrence in patients with resected stage I NSCLC." -tissue_expression_ns hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 20975375 "In an exploratory study, we determined whether expression of six miRNAs (let-7a, miR-7, miR-21, miR-155, miR-210, and miR-221) previously reported to correlate with invasiveness or outcome in various human malignancies were associated with tumor recurrence in patients with resected stage I NSCLC." -tissue_expression_ns hsa-mir-210 "Carcinoma, Lung, Non-Small-Cell" 20975375 "In an exploratory study, we determined whether expression of six miRNAs (let-7a, miR-7, miR-21, miR-155, miR-210, and miR-221) previously reported to correlate with invasiveness or outcome in various human malignancies were associated with tumor recurrence in patients with resected stage I NSCLC." -tissue_expression_ns hsa-mir-221 "Carcinoma, Lung, Non-Small-Cell" 20975375 "In an exploratory study, we determined whether expression of six miRNAs (let-7a, miR-7, miR-21, miR-155, miR-210, and miR-221) previously reported to correlate with invasiveness or outcome in various human malignancies were associated with tumor recurrence in patients with resected stage I NSCLC." -tissue_expression_ns hsa-mir-7 "Carcinoma, Lung, Non-Small-Cell" 20975375 "In an exploratory study, we determined whether expression of six miRNAs (let-7a, miR-7, miR-21, miR-155, miR-210, and miR-221) previously reported to correlate with invasiveness or outcome in various human malignancies were associated with tumor recurrence in patients with resected stage I NSCLC." -tissue_expression_ns hsa-let-7a "Carcinoma, Lung, Non-Small-Cell" 20978195 "We also analyzed the association of TP53 mutation status and miR-34a/b/c expression, epidermal growth factor receptor and KRAS mutation status, and miR-21 and Let-7a expression." -tissue_expression_ns hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 20978195 "We also analyzed the association of TP53 mutation status and miR-34a/b/c expression, epidermal growth factor receptor and KRAS mutation status, and miR-21 and Let-7a expression." -tissue_expression_ns hsa-mir-34a "Carcinoma, Lung, Non-Small-Cell" 20978195 "We also analyzed the association of TP53 mutation status and miR-34a/b/c expression, epidermal growth factor receptor and KRAS mutation status, and miR-21 and Let-7a expression." -tissue_expression_ns hsa-mir-34b "Carcinoma, Lung, Non-Small-Cell" 20978195 "We also analyzed the association of TP53 mutation status and miR-34a/b/c expression, epidermal growth factor receptor and KRAS mutation status, and miR-21 and Let-7a expression." -tissue_expression_ns hsa-mir-34c "Carcinoma, Lung, Non-Small-Cell" 20978195 "We also analyzed the association of TP53 mutation status and miR-34a/b/c expression, epidermal growth factor receptor and KRAS mutation status, and miR-21 and Let-7a expression." -tissue_expression_ns hsa-mir-155 "Adenocarcinoma, Pancreatic Ductal" 21068491 MicroRNA-21 and microRNA-155 in pancreatic juice have the potential of becoming biomarkers for diagnosing pancreatic ductal adenocarcinoma. -tissue_expression_ns hsa-mir-21 "Adenocarcinoma, Pancreatic Ductal" 21068491 MicroRNA-21 and microRNA-155 in pancreatic juice have the potential of becoming biomarkers for diagnosing pancreatic ductal adenocarcinoma. -tissue_expression_ns hsa-mir-153 Ovarian Neoplasms 21083603 "Deregulation of miR-519a, 153, and 485-5p and its clinicopathological relevance in ovarian epithelial tumours." -tissue_expression_ns hsa-mir-485 Ovarian Neoplasms 21083603 "Deregulation of miR-519a, 153, and 485-5p and its clinicopathological relevance in ovarian epithelial tumours." -tissue_expression_ns hsa-mir-519a Ovarian Neoplasms 21083603 "Deregulation of miR-519a, 153, and 485-5p and its clinicopathological relevance in ovarian epithelial tumours." -tissue_expression_ns hsa-let-7a Lung Neoplasms 21102586 "In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a)." -tissue_expression_ns hsa-let-7b Lung Neoplasms 21102586 "In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a)." -tissue_expression_ns hsa-let-7c Lung Neoplasms 21102586 "In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a)." -tissue_expression_ns hsa-let-7d Lung Neoplasms 21102586 "In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a)." -tissue_expression_ns hsa-let-7e Lung Neoplasms 21102586 "In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a)." -tissue_expression_ns hsa-let-7f Lung Neoplasms 21102586 "In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a)." -tissue_expression_ns hsa-let-7g Lung Neoplasms 21102586 "In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a)." -tissue_expression_ns hsa-let-7i Lung Neoplasms 21102586 "In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a)." -tissue_expression_ns hsa-mir-126 Lung Neoplasms 21102586 "In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a)." -tissue_expression_ns hsa-mir-15a Lung Neoplasms 21102586 "In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a)." -tissue_expression_ns hsa-mir-202 Lung Neoplasms 21102586 "In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a)." -tissue_expression_ns hsa-mir-21 Lung Neoplasms 21102586 "In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a)." -tissue_expression_ns hsa-mir-25 Lung Neoplasms 21102586 "In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a)." -tissue_expression_ns hsa-mir-98 Lung Neoplasms 21102586 "In AD cases,a SNP within the same haplotype was associated with reduced RNASEN mRNA expression (P=0.013) and with miR expression changes (global P=0.007) of miRs known to be associated with cancer(e.g.,let-7 family, miR-21, miR-25, miR-126 and miR15a)." -tissue_expression_ns hsa-mir-15a Pancreatic Neoplasms 21106054 Dysregulation of miR-15a and miR-214 in human pancreatic cancer. -tissue_expression_ns hsa-mir-214 Pancreatic Neoplasms 21106054 Dysregulation of miR-15a and miR-214 in human pancreatic cancer. -tissue_expression_ns hsa-mir-133a Bone Disease [unspecific] 21108928 "The expression of miRNAs, including miR-18a, miR-133a, miR-141 and miR-19a, was significantly altered in the PDLSCs cultured with ibandronate." -tissue_expression_ns hsa-mir-141 Bone Disease [unspecific] 21108928 "The expression of miRNAs, including miR-18a, miR-133a, miR-141 and miR-19a, was significantly altered in the PDLSCs cultured with ibandronate." -tissue_expression_ns hsa-mir-18a Bone Disease [unspecific] 21108928 "The expression of miRNAs, including miR-18a, miR-133a, miR-141 and miR-19a, was significantly altered in the PDLSCs cultured with ibandronate." -tissue_expression_ns hsa-mir-19a Bone Disease [unspecific] 21108928 "The expression of miRNAs, including miR-18a, miR-133a, miR-141 and miR-19a, was significantly altered in the PDLSCs cultured with ibandronate." -tissue_expression_ns hsa-mir-1-1 Urinary Bladder Cancer 21133599 dysregulated -tissue_expression_ns hsa-mir-1-2 Urinary Bladder Cancer 21133599 dysregulated -tissue_expression_ns hsa-mir-125b-1 Urinary Bladder Cancer 21133599 dysregulated -tissue_expression_ns hsa-mir-125b-2 Urinary Bladder Cancer 21133599 dysregulated -tissue_expression_ns hsa-mir-133a-1 Urinary Bladder Cancer 21133599 dysregulated -tissue_expression_ns hsa-mir-133a-2 Urinary Bladder Cancer 21133599 dysregulated -tissue_expression_ns hsa-mir-133b Urinary Bladder Cancer 21133599 dysregulated -tissue_expression_ns hsa-mir-143 Urinary Bladder Cancer 21133599 dysregulated -tissue_expression_ns hsa-mir-145 Urinary Bladder Cancer 21133599 dysregulated -tissue_expression_ns hsa-mir-200b Urinary Bladder Cancer 21133599 dysregulated -tissue_expression_ns hsa-mir-708 Urinary Bladder Cancer 21133599 dysregulated -tissue_expression_ns hsa-mir-99a Urinary Bladder Cancer 21133599 dysregulated -tissue_expression_ns hsa-mir-99b Urinary Bladder Cancer 21133599 dysregulated -tissue_expression_ns hsa-mir-129-1 Brain Neoplasms 21157891 "MicroRNA-129, miR-142-5p, and miR-25 were differ entially expressed in every pediatric brain tumor type compared to normal tissue controls as measured by microarray." -tissue_expression_ns hsa-mir-129-2 Brain Neoplasms 21157891 "MicroRNA-129, miR-142-5p, and miR-25 were differ entially expressed in every pediatric brain tumor type compared to normal tissue controls as measured by microarray." -tissue_expression_ns hsa-let-7c Nevus 21166724 The microRNA molecular signature of atypic and common acquired melanocytic nevi: differential expression of miR-125b and let-7c. -tissue_expression_ns hsa-mir-125b-1 Nevus 21166724 The microRNA molecular signature of atypic and common acquired melanocytic nevi: differential expression of miR-125b and let-7c. -tissue_expression_ns hsa-mir-125b-2 Nevus 21166724 The microRNA molecular signature of atypic and common acquired melanocytic nevi: differential expression of miR-125b and let-7c. -tissue_expression_ns hsa-mir-29a "Aortic Aneurysm, Thoracic" 21334170 dysregulated -tissue_expression_ns hsa-mir-29b-1 "Aortic Aneurysm, Thoracic" 21334170 dysregulated -tissue_expression_ns hsa-mir-29b-2 "Aortic Aneurysm, Thoracic" 21334170 dysregulated -tissue_expression_ns hsa-mir-29c "Aortic Aneurysm, Thoracic" 21334170 dysregulated -tissue_expression_ns hsa-mir-30a "Aortic Aneurysm, Thoracic" 21334170 dysregulated -tissue_expression_ns hsa-mir-30b "Aortic Aneurysm, Thoracic" 21334170 dysregulated -tissue_expression_ns hsa-mir-30c-1 "Aortic Aneurysm, Thoracic" 21334170 dysregulated -tissue_expression_ns hsa-mir-30c-2 "Aortic Aneurysm, Thoracic" 21334170 dysregulated -tissue_expression_ns hsa-mir-30d "Aortic Aneurysm, Thoracic" 21334170 dysregulated -tissue_expression_ns hsa-mir-30e "Aortic Aneurysm, Thoracic" 21334170 dysregulated -tissue_expression_ns hsa-mir-125a Endometriosis 21335415 "TaqMan real-time PCR was used to assess the expression of the miRNAs (miR-15b, -16, -17-5p, -20a, -21, -125a, -221 and -222), while VEGF-A and TSP-1 mRNA were assessed by real-time PCR, with SYBR Green I and VEGF-A and TSP-1 protein levels were quantified by ELISA." -tissue_expression_ns hsa-mir-15b Endometriosis 21335415 "TaqMan real-time PCR was used to assess the expression of the miRNAs (miR-15b, -16, -17-5p, -20a, -21, -125a, -221 and -222), while VEGF-A and TSP-1 mRNA were assessed by real-time PCR, with SYBR Green I and VEGF-A and TSP-1 protein levels were quantified by ELISA." -tissue_expression_ns hsa-mir-16 Endometriosis 21335415 "TaqMan real-time PCR was used to assess the expression of the miRNAs (miR-15b, -16, -17-5p, -20a, -21, -125a, -221 and -222), while VEGF-A and TSP-1 mRNA were assessed by real-time PCR, with SYBR Green I and VEGF-A and TSP-1 protein levels were quantified by ELISA." -tissue_expression_ns hsa-mir-17 Endometriosis 21335415 "TaqMan real-time PCR was used to assess the expression of the miRNAs (miR-15b, -16, -17-5p, -20a, -21, -125a, -221 and -222), while VEGF-A and TSP-1 mRNA were assessed by real-time PCR, with SYBR Green I and VEGF-A and TSP-1 protein levels were quantified by ELISA." -tissue_expression_ns hsa-mir-20a Endometriosis 21335415 "TaqMan real-time PCR was used to assess the expression of the miRNAs (miR-15b, -16, -17-5p, -20a, -21, -125a, -221 and -222), while VEGF-A and TSP-1 mRNA were assessed by real-time PCR, with SYBR Green I and VEGF-A and TSP-1 protein levels were quantified by ELISA." -tissue_expression_ns hsa-mir-21 Endometriosis 21335415 "TaqMan real-time PCR was used to assess the expression of the miRNAs (miR-15b, -16, -17-5p, -20a, -21, -125a, -221 and -222), while VEGF-A and TSP-1 mRNA were assessed by real-time PCR, with SYBR Green I and VEGF-A and TSP-1 protein levels were quantified by ELISA." -tissue_expression_ns hsa-mir-221 Endometriosis 21335415 "TaqMan real-time PCR was used to assess the expression of the miRNAs (miR-15b, -16, -17-5p, -20a, -21, -125a, -221 and -222), while VEGF-A and TSP-1 mRNA were assessed by real-time PCR, with SYBR Green I and VEGF-A and TSP-1 protein levels were quantified by ELISA." -tissue_expression_ns hsa-mir-222 Endometriosis 21335415 "TaqMan real-time PCR was used to assess the expression of the miRNAs (miR-15b, -16, -17-5p, -20a, -21, -125a, -221 and -222), while VEGF-A and TSP-1 mRNA were assessed by real-time PCR, with SYBR Green I and VEGF-A and TSP-1 protein levels were quantified by ELISA." -tissue_expression_ns hsa-mir-182 Mesothelioma 21358347 dysregulated -tissue_expression_ns hsa-mir-214 Mesothelioma 21358347 dysregulated -tissue_expression_ns hsa-mir-497 Mesothelioma 21358347 dysregulated -tissue_expression_ns hsa-mir-7-1 Mesothelioma 21358347 dysregulated -tissue_expression_ns hsa-mir-7-2 Mesothelioma 21358347 dysregulated -tissue_expression_ns hsa-mir-7-3 Mesothelioma 21358347 dysregulated -tissue_expression_ns hsa-mir-21 Ischemia 21373187 deregulated -tissue_expression_ns hsa-mir-29b-1 Ischemia 21373187 deregulated -tissue_expression_ns hsa-mir-29b-2 Ischemia 21373187 deregulated -tissue_expression_ns hsa-mir-30b Ischemia 21373187 deregulated -tissue_expression_ns hsa-mir-125b-1 Breast Neoplasms 21375733 dysregulated -tissue_expression_ns hsa-mir-125b-2 Breast Neoplasms 21375733 dysregulated -tissue_expression_ns hsa-mir-182 Breast Neoplasms 21375733 dysregulated -tissue_expression_ns hsa-mir-183 Breast Neoplasms 21375733 dysregulated -tissue_expression_ns hsa-mir-195 Breast Neoplasms 21375733 dysregulated -tissue_expression_ns hsa-mir-1-1 Myocardial Infarction 21386882 "miR-1, miR-29b and miR-98 dysregulated." -tissue_expression_ns hsa-mir-1-2 Myocardial Infarction 21386882 "miR-1, miR-29b and miR-98 dysregulated." -tissue_expression_ns hsa-mir-29b-1 Myocardial Infarction 21386882 "miR-1, miR-29b and miR-98 dysregulated." -tissue_expression_ns hsa-mir-29b-2 Myocardial Infarction 21386882 "miR-1, miR-29b and miR-98 dysregulated." -tissue_expression_ns hsa-mir-98 Myocardial Infarction 21386882 "miR-1, miR-29b and miR-98 dysregulated." -tissue_expression_ns hsa-mir-143 Prostate Neoplasms 21400514 "The differential expression of miRNAs miR-375, miR-143 and miR-145 was validated by quantitative PCR. MiRNA in situ hybridization revealed that the differential expression is cancer-cell associated." -tissue_expression_ns hsa-mir-145 Prostate Neoplasms 21400514 "The differential expression of miRNAs miR-375, miR-143 and miR-145 was validated by quantitative PCR. MiRNA in situ hybridization revealed that the differential expression is cancer-cell associated." -tissue_expression_ns hsa-mir-375 Prostate Neoplasms 21400514 "The differential expression of miRNAs miR-375, miR-143 and miR-145 was validated by quantitative PCR. MiRNA in situ hybridization revealed that the differential expression is cancer-cell associated." -tissue_expression_ns hsa-let-7a-1 Barrett Esophagus 21407181 differential expression between Barrett Esophagus patients with and without dysplasia. -tissue_expression_ns hsa-let-7a-2 Barrett Esophagus 21407181 differential expression between Barrett Esophagus patients with and without dysplasia. -tissue_expression_ns hsa-let-7a-3 Barrett Esophagus 21407181 differential expression between Barrett Esophagus patients with and without dysplasia. -tissue_expression_ns hsa-mir-145 Barrett Esophagus 21407181 differential expression between Barrett Esophagus patients with and without dysplasia. -tissue_expression_ns hsa-mir-15b Barrett Esophagus 21407181 differential expression between Barrett Esophagus patients with and without dysplasia. -tissue_expression_ns hsa-mir-203 Barrett Esophagus 21407181 differential expression between Barrett Esophagus patients with and without dysplasia. -tissue_expression_ns hsa-mir-21 Barrett Esophagus 21407181 differential expression between Barrett Esophagus patients with and without dysplasia. -tissue_expression_ns hsa-mir-486 Barrett Esophagus 21407181 differential expression between Barrett Esophagus patients with and without dysplasia. -tissue_expression_ns hsa-let-7i Cerebral Malaria 21422175 "We identified three miRNAs that were differentially expressed in the brain of PbA-infected CBA mice: let7i, miR-27a, and miR-150." -tissue_expression_ns hsa-mir-150 Cerebral Malaria 21422175 "We identified three miRNAs that were differentially expressed in the brain of PbA-infected CBA mice: let7i, miR-27a, and miR-150." -tissue_expression_ns hsa-mir-27a Cerebral Malaria 21422175 "We identified three miRNAs that were differentially expressed in the brain of PbA-infected CBA mice: let7i, miR-27a, and miR-150." -tissue_expression_ns hsa-mir-196a-1 Pancreatic Neoplasms 21463235 altered expression -tissue_expression_ns hsa-mir-196a-2 Pancreatic Neoplasms 21463235 altered expression -tissue_expression_ns hsa-mir-217 Pancreatic Neoplasms 21463235 altered expression -tissue_expression_ns hsa-mir-133a-1 Colorectal Carcinoma 21532750 "miR-215, miR-137, miR-708, miR-31,and miR-135b were differentially expressed in APC tumors and miR-215, miR-133a,miR-467d, miR-218, miR-708, miR-31, and miR-135b in colitis-associated tumors." -tissue_expression_ns hsa-mir-133a-2 Colorectal Carcinoma 21532750 "miR-215, miR-137, miR-708, miR-31,and miR-135b were differentially expressed in APC tumors and miR-215, miR-133a,miR-467d, miR-218, miR-708, miR-31, and miR-135b in colitis-associated tumors." -tissue_expression_ns hsa-mir-135b Colorectal Carcinoma 21532750 "miR-215, miR-137, miR-708, miR-31,and miR-135b were differentially expressed in APC tumors and miR-215, miR-133a,miR-467d, miR-218, miR-708, miR-31, and miR-135b in colitis-associated tumors." -tissue_expression_ns hsa-mir-137 Colorectal Carcinoma 21532750 "miR-215, miR-137, miR-708, miR-31,and miR-135b were differentially expressed in APC tumors and miR-215, miR-133a,miR-467d, miR-218, miR-708, miR-31, and miR-135b in colitis-associated tumors." -tissue_expression_ns hsa-mir-215 Colorectal Carcinoma 21532750 "miR-215, miR-137, miR-708, miR-31,and miR-135b were differentially expressed in APC tumors and miR-215, miR-133a,miR-467d, miR-218, miR-708, miR-31, and miR-135b in colitis-associated tumors." -tissue_expression_ns hsa-mir-218-1 Colorectal Carcinoma 21532750 "miR-215, miR-137, miR-708, miR-31,and miR-135b were differentially expressed in APC tumors and miR-215, miR-133a,miR-467d, miR-218, miR-708, miR-31, and miR-135b in colitis-associated tumors." -tissue_expression_ns hsa-mir-218-2 Colorectal Carcinoma 21532750 "miR-215, miR-137, miR-708, miR-31,and miR-135b were differentially expressed in APC tumors and miR-215, miR-133a,miR-467d, miR-218, miR-708, miR-31, and miR-135b in colitis-associated tumors." -tissue_expression_ns hsa-mir-31 Colorectal Carcinoma 21532750 "miR-215, miR-137, miR-708, miR-31,and miR-135b were differentially expressed in APC tumors and miR-215, miR-133a,miR-467d, miR-218, miR-708, miR-31, and miR-135b in colitis-associated tumors." -tissue_expression_ns hsa-mir-708 Colorectal Carcinoma 21532750 "miR-215, miR-137, miR-708, miR-31,and miR-135b were differentially expressed in APC tumors and miR-215, miR-133a,miR-467d, miR-218, miR-708, miR-31, and miR-135b in colitis-associated tumors." -tissue_expression_ns hsa-mir-150 Psoriasis 21687694 differentially expressed -tissue_expression_ns hsa-mir-197 Psoriasis 21687694 differentially expressed -tissue_expression_ns hsa-mir-423 Psoriasis 21687694 differentially expressed -tissue_expression_ns hsa-mir-1-1 Colorectal Carcinoma 21694772 deregulated -tissue_expression_ns hsa-mir-1-2 Colorectal Carcinoma 21694772 deregulated -tissue_expression_ns hsa-mir-135a-1 Colorectal Carcinoma 21694772 deregulated -tissue_expression_ns hsa-mir-135a-2 Colorectal Carcinoma 21694772 deregulated -tissue_expression_ns hsa-mir-135b Colorectal Carcinoma 21694772 deregulated -tissue_expression_ns hsa-mir-137 Colorectal Carcinoma 21694772 deregulated -tissue_expression_ns hsa-mir-31 Colorectal Carcinoma 21694772 deregulated -tissue_expression_ns hsa-mir-9-1 Colorectal Carcinoma 21694772 deregulated -tissue_expression_ns hsa-mir-9-2 Colorectal Carcinoma 21694772 deregulated -tissue_expression_ns hsa-mir-9-3 Colorectal Carcinoma 21694772 deregulated -tissue_expression_ns hsa-mir-99a Colorectal Carcinoma 21694772 deregulated -tissue_expression_ns hsa-mir-1 Heart Failure 21737570 "In particular, miRNA-1, miRNA-21, miRNA-24, miRNA-29, miRNA-92a, miRNA-126, miRNA-133, miRNA-320, miRNA-199a, miRNA-208, and miRNA-195 have been shown to be regulated after I/R injury." -tissue_expression_ns hsa-mir-126 Heart Failure 21737570 "In particular, miRNA-1, miRNA-21, miRNA-24, miRNA-29, miRNA-92a, miRNA-126, miRNA-133, miRNA-320, miRNA-199a, miRNA-208, and miRNA-195 have been shown to be regulated after I/R injury." -tissue_expression_ns hsa-mir-133 Heart Failure 21737570 "In particular, miRNA-1, miRNA-21, miRNA-24, miRNA-29, miRNA-92a, miRNA-126, miRNA-133, miRNA-320, miRNA-199a, miRNA-208, and miRNA-195 have been shown to be regulated after I/R injury." -tissue_expression_ns hsa-mir-195 Heart Failure 21737570 "In particular, miRNA-1, miRNA-21, miRNA-24, miRNA-29, miRNA-92a, miRNA-126, miRNA-133, miRNA-320, miRNA-199a, miRNA-208, and miRNA-195 have been shown to be regulated after I/R injury." -tissue_expression_ns hsa-mir-199a Heart Failure 21737570 "In particular, miRNA-1, miRNA-21, miRNA-24, miRNA-29, miRNA-92a, miRNA-126, miRNA-133, miRNA-320, miRNA-199a, miRNA-208, and miRNA-195 have been shown to be regulated after I/R injury." -tissue_expression_ns hsa-mir-208 Heart Failure 21737570 "In particular, miRNA-1, miRNA-21, miRNA-24, miRNA-29, miRNA-92a, miRNA-126, miRNA-133, miRNA-320, miRNA-199a, miRNA-208, and miRNA-195 have been shown to be regulated after I/R injury." -tissue_expression_ns hsa-mir-24 Heart Failure 21737570 "In particular, miRNA-1, miRNA-21, miRNA-24, miRNA-29, miRNA-92a, miRNA-126, miRNA-133, miRNA-320, miRNA-199a, miRNA-208, and miRNA-195 have been shown to be regulated after I/R injury." -tissue_expression_ns hsa-mir-29 Heart Failure 21737570 "In particular, miRNA-1, miRNA-21, miRNA-24, miRNA-29, miRNA-92a, miRNA-126, miRNA-133, miRNA-320, miRNA-199a, miRNA-208, and miRNA-195 have been shown to be regulated after I/R injury." -tissue_expression_ns hsa-mir-320 Heart Failure 21737570 "In particular, miRNA-1, miRNA-21, miRNA-24, miRNA-29, miRNA-92a, miRNA-126, miRNA-133, miRNA-320, miRNA-199a, miRNA-208, and miRNA-195 have been shown to be regulated after I/R injury." -tissue_expression_ns hsa-mir-92a Heart Failure 21737570 "In particular, miRNA-1, miRNA-21, miRNA-24, miRNA-29, miRNA-92a, miRNA-126, miRNA-133, miRNA-320, miRNA-199a, miRNA-208, and miRNA-195 have been shown to be regulated after I/R injury." -tissue_expression_ns hsa-mir-216a Fatty Liver [unspecific] 21764575 altered expression -tissue_expression_ns hsa-mir-216b Fatty Liver [unspecific] 21764575 altered expression -tissue_expression_ns hsa-mir-302a Fatty Liver [unspecific] 21764575 altered expression -tissue_expression_ns hsa-mir-146b Thyroid Neoplasms 21778212 "In this context, a small set of miRNAs (i.e. miR-7, miR-146a, miR-146b, miR-200b, miR-221, and miR-222) appears to be useful, though not sufficient per se, in distinguishing TT-UMP from other WDT of the thyroid gland." -tissue_expression_ns hsa-mir-200b Thyroid Neoplasms 21778212 "In this context, a small set of miRNAs (i.e. miR-7, miR-146a, miR-146b, miR-200b, miR-221, and miR-222) appears to be useful, though not sufficient per se, in distinguishing TT-UMP from other WDT of the thyroid gland." -tissue_expression_ns hsa-mir-221 Thyroid Neoplasms 21778212 "In this context, a small set of miRNAs (i.e. miR-7, miR-146a, miR-146b, miR-200b, miR-221, and miR-222) appears to be useful, though not sufficient per se, in distinguishing TT-UMP from other WDT of the thyroid gland." -tissue_expression_ns hsa-mir-222 Thyroid Neoplasms 21778212 "In this context, a small set of miRNAs (i.e. miR-7, miR-146a, miR-146b, miR-200b, miR-221, and miR-222) appears to be useful, though not sufficient per se, in distinguishing TT-UMP from other WDT of the thyroid gland." -tissue_expression_ns hsa-mir-7 Thyroid Neoplasms 21778212 "In this context, a small set of miRNAs (i.e. miR-7, miR-146a, miR-146b, miR-200b, miR-221, and miR-222) appears to be useful, though not sufficient per se, in distinguishing TT-UMP from other WDT of the thyroid gland." -tissue_expression_ns hsa-mir-100 Pancreatic Neoplasms 21785383 "Differentially expressed miRNAs including miR-99a, miR-100, miR-125b, miR-192, and miR-429 were detected in pancreatic cancer stem cells." -tissue_expression_ns hsa-mir-125b-1 Pancreatic Neoplasms 21785383 "Differentially expressed miRNAs including miR-99a, miR-100, miR-125b, miR-192, and miR-429 were detected in pancreatic cancer stem cells." -tissue_expression_ns hsa-mir-125b-2 Pancreatic Neoplasms 21785383 "Differentially expressed miRNAs including miR-99a, miR-100, miR-125b, miR-192, and miR-429 were detected in pancreatic cancer stem cells." -tissue_expression_ns hsa-mir-192 Pancreatic Neoplasms 21785383 "Differentially expressed miRNAs including miR-99a, miR-100, miR-125b, miR-192, and miR-429 were detected in pancreatic cancer stem cells." -tissue_expression_ns hsa-mir-429 Pancreatic Neoplasms 21785383 "Differentially expressed miRNAs including miR-99a, miR-100, miR-125b, miR-192, and miR-429 were detected in pancreatic cancer stem cells." -tissue_expression_ns hsa-mir-99a Pancreatic Neoplasms 21785383 "Differentially expressed miRNAs including miR-99a, miR-100, miR-125b, miR-192, and miR-429 were detected in pancreatic cancer stem cells." -tissue_expression_ns hsa-mir-135b Osteosarcoma 21789031 deregulated -tissue_expression_ns hsa-mir-150 Osteosarcoma 21789031 deregulated -tissue_expression_ns hsa-mir-542 Osteosarcoma 21789031 miR-542-5p: deregulated -tissue_expression_ns hsa-mir-652 Osteosarcoma 21789031 deregulated -tissue_expression_ns hsa-mir-146a Periodontal Diseases 21789961 "hsa-mirNA-146a, hsa-miRNA-146b, and hsa-miRNA-155, showed significant differences between inflamed and healthy gingiva." -tissue_expression_ns hsa-mir-146b Periodontal Diseases 21789961 "hsa-mirNA-146a, hsa-miRNA-146b, and hsa-miRNA-155, showed significant differences between inflamed and healthy gingiva." -tissue_expression_ns hsa-mir-155 Periodontal Diseases 21789961 "hsa-mirNA-146a, hsa-miRNA-146b, and hsa-miRNA-155, showed significant differences between inflamed and healthy gingiva." -tissue_expression_ns hsa-mir-107 Chronic Kidney Disease 21794090 "Differential expression was detected for miR-142-3p, miR-204, miR-107 and miR-211 (p < 0.001) and miR-32 (p < 0.05)." -tissue_expression_ns hsa-mir-142 Chronic Kidney Disease 21794090 "Differential expression was detected for miR-142-3p, miR-204, miR-107 and miR-211 (p < 0.001) and miR-32 (p < 0.05). Furthermore, differential expression of miR-142-3p (p < 0.01), miR-204 (p < 0.01) and miR-211 (p < 0.05) was also observed between patient groups in urine samples." -tissue_expression_ns hsa-mir-204 Chronic Kidney Disease 21794090 "Differential expression was detected for miR-142-3p, miR-204, miR-107 and miR-211 (p < 0.001) and miR-32 (p < 0.05). Furthermore, differential expression of miR-142-3p (p < 0.01), miR-204 (p < 0.01) and miR-211 (p < 0.05) was also observed between patient groups in urine samples." -tissue_expression_ns hsa-mir-211 Chronic Kidney Disease 21794090 "Differential expression was detected for miR-142-3p, miR-204, miR-107 and miR-211 (p < 0.001) and miR-32 (p < 0.05). Furthermore, differential expression of miR-142-3p (p < 0.01), miR-204 (p < 0.01) and miR-211 (p < 0.05) was also observed between patient groups in urine samples." -tissue_expression_ns hsa-mir-32 Chronic Kidney Disease 21794090 "Differential expression was detected for miR-142-3p, miR-204, miR-107 and miR-211 (p < 0.001) and miR-32 (p < 0.05)." -tissue_expression_ns hsa-mir-100 Psoriasis 21807764 deregulated -tissue_expression_ns hsa-mir-142 Psoriasis 21807764 miR-142-3p: deregulated -tissue_expression_ns hsa-mir-21 Psoriasis 21807764 deregulated -tissue_expression_ns hsa-mir-223 Psoriasis 21807764 miR-223 and miR-223*: deregulated -tissue_expression_ns hsa-mir-378a Psoriasis 21807764 deregulated -tissue_expression_ns hsa-mir-146b "Carcinoma, Thyroid, Papillary" 21842215 miRNA profiling of hyalinizing trabecular tumours compared with benign thyroid lesions and papillary thyroid carcinoma failed to demonstrate the characteristic up-regulation found in papillary thyroid carcinoma -tissue_expression_ns hsa-mir-181b "Carcinoma, Thyroid, Papillary" 21842215 miRNA profiling of hyalinizing trabecular tumours compared with benign thyroid lesions and papillary thyroid carcinoma failed to demonstrate the characteristic up-regulation found in papillary thyroid carcinoma -tissue_expression_ns hsa-mir-21 "Carcinoma, Thyroid, Papillary" 21842215 miRNA profiling of hyalinizing trabecular tumours compared with benign thyroid lesions and papillary thyroid carcinoma failed to demonstrate the characteristic up-regulation found in papillary thyroid carcinoma -tissue_expression_ns hsa-mir-221 "Carcinoma, Thyroid, Papillary" 21842215 miRNA profiling of hyalinizing trabecular tumours compared with benign thyroid lesions and papillary thyroid carcinoma failed to demonstrate the characteristic up-regulation found in papillary thyroid carcinoma -tissue_expression_ns hsa-mir-222 "Carcinoma, Thyroid, Papillary" 21842215 miRNA profiling of hyalinizing trabecular tumours compared with benign thyroid lesions and papillary thyroid carcinoma failed to demonstrate the characteristic up-regulation found in papillary thyroid carcinoma -tissue_expression_ns hsa-mir-143 Gastric Neoplasms 21874264 "miR-32,miR-182 and miR-143 dysregulated expression levels are related with different pathological stages of intestinal-type gastric cancers." -tissue_expression_ns hsa-mir-145 Gastric Neoplasms 21874264 "miR-145, miR-27a, miR-494 are differently expressed between intestinal-type and diffuse-type gastric cancers." -tissue_expression_ns hsa-mir-182 Gastric Neoplasms 21874264 "miR-32,miR-182 and miR-143 dysregulated expression levels are related with different pathological stages of intestinal-type gastric cancers." -tissue_expression_ns hsa-mir-27a Gastric Neoplasms 21874264 "miR-145, miR-27a, miR-494 are differently expressed between intestinal-type and diffuse-type gastric cancers." -tissue_expression_ns hsa-mir-32 Gastric Neoplasms 21874264 "miR-32,miR-182 and miR-143 dysregulated expression levels are related with different pathological stages of intestinal-type gastric cancers." -tissue_expression_ns hsa-mir-494 Gastric Neoplasms 21874264 "miR-145, miR-27a, miR-494 are differently expressed between intestinal-type and diffuse-type gastric cancers." -tissue_expression_ns hsa-mir-125b "Carcinoma, Hepatocellular" 21882851 "Many aberrantly expressed miRNAs were related to various cancers (e.g., miR-125b, hepatocellular carcinoma; miR-21, leukemia; miR-16, chronic lymphocytic leukemia;miR-192, pituitary adenomas; miR-199a-3p, ovarian cancer; miR-34a, pancreatic cancer)." -tissue_expression_ns hsa-mir-16 "Leukemia, Lymphocytic, Chronic, B-Cell" 21882851 "Many aberrantly expressed miRNAs were related to various cancers (e.g., miR-125b, hepatocellular carcinoma; miR-21, leukemia; miR-16, chronic lymphocytic leukemia;miR-192, pituitary adenomas; miR-199a-3p, ovarian cancer; miR-34a, pancreatic cancer)." -tissue_expression_ns hsa-mir-192 Pituitary Adenoma 21882851 "Many aberrantly expressed miRNAs were related to various cancers (e.g., miR-125b, hepatocellular carcinoma; miR-21, leukemia; miR-16, chronic lymphocytic leukemia;miR-192, pituitary adenomas; miR-199a-3p, ovarian cancer; miR-34a, pancreatic cancer)." -tissue_expression_ns hsa-mir-199a Ovarian Neoplasms 21882851 "Many aberrantly expressed miRNAs were related to various cancers (e.g., miR-125b, hepatocellular carcinoma; miR-21, leukemia; miR-16, chronic lymphocytic leukemia;miR-192, pituitary adenomas; miR-199a-3p, ovarian cancer; miR-34a, pancreatic cancer)." -tissue_expression_ns hsa-mir-21 Leukemia 21882851 "Many aberrantly expressed miRNAs were related to various cancers (e.g., miR-125b, hepatocellular carcinoma; miR-21, leukemia; miR-16, chronic lymphocytic leukemia;miR-192, pituitary adenomas; miR-199a-3p, ovarian cancer; miR-34a, pancreatic cancer)." -tissue_expression_ns hsa-mir-34a Pancreatic Neoplasms 21882851 "Many aberrantly expressed miRNAs were related to various cancers (e.g., miR-125b, hepatocellular carcinoma; miR-21, leukemia; miR-16, chronic lymphocytic leukemia;miR-192, pituitary adenomas; miR-199a-3p, ovarian cancer; miR-34a, pancreatic cancer)." -tissue_expression_ns hsa-mir-140 "Squamous Cell Carcinoma, Lung" 21890451 "The authors identified a five-microRNA classifier (hsa-miR-210, hsa-miR-182, hsa-miR-486-5p, hsa-miR-30a and hsa-miR-140-3p) that could distinguish SCC (Squamous cell carcinoma) from normal lung tissues." -tissue_expression_ns hsa-mir-182 "Squamous Cell Carcinoma, Lung" 21890451 "The authors identified a five-microRNA classifier (hsa-miR-210, hsa-miR-182, hsa-miR-486-5p, hsa-miR-30a and hsa-miR-140-3p) that could distinguish SCC (Squamous cell carcinoma) from normal lung tissues." -tissue_expression_ns hsa-mir-210 "Squamous Cell Carcinoma, Lung" 21890451 "The authors identified a five-microRNA classifier (hsa-miR-210, hsa-miR-182, hsa-miR-486-5p, hsa-miR-30a and hsa-miR-140-3p) that could distinguish SCC (Squamous cell carcinoma) from normal lung tissues." -tissue_expression_ns hsa-mir-30a "Squamous Cell Carcinoma, Lung" 21890451 "The authors identified a five-microRNA classifier (hsa-miR-210, hsa-miR-182, hsa-miR-486-5p, hsa-miR-30a and hsa-miR-140-3p) that could distinguish SCC (Squamous cell carcinoma) from normal lung tissues." -tissue_expression_ns hsa-mir-486 "Squamous Cell Carcinoma, Lung" 21890451 "The authors identified a five-microRNA classifier (hsa-miR-210, hsa-miR-182, hsa-miR-486-5p, hsa-miR-30a and hsa-miR-140-3p) that could distinguish SCC (Squamous cell carcinoma) from normal lung tissues." -tissue_expression_ns hsa-mir-10a Breast Neoplasms 21955614 Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells. -tissue_expression_ns hsa-mir-125b-1 Breast Neoplasms 21955614 Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells. -tissue_expression_ns hsa-mir-125b-2 Breast Neoplasms 21955614 Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells. -tissue_expression_ns hsa-mir-181a-2 Breast Neoplasms 21955614 Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells. -tissue_expression_ns hsa-mir-181b-1 Breast Neoplasms 21955614 Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells. -tissue_expression_ns hsa-mir-181b-2 Breast Neoplasms 21955614 Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells. -tissue_expression_ns hsa-mir-200a Breast Neoplasms 21955614 Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells. -tissue_expression_ns hsa-mir-200b Breast Neoplasms 21955614 Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells. -tissue_expression_ns hsa-mir-200c Breast Neoplasms 21955614 Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells. -tissue_expression_ns hsa-mir-205 Breast Neoplasms 21955614 Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells. -tissue_expression_ns hsa-mir-21 Breast Neoplasms 21955614 Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells. -tissue_expression_ns hsa-mir-22 Breast Neoplasms 21955614 Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells. -tissue_expression_ns hsa-mir-222 Breast Neoplasms 21955614 Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells -tissue_expression_ns hsa-mir-29a Breast Neoplasms 21955614 Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells. -tissue_expression_ns hsa-mir-93 Breast Neoplasms 21955614 Differential expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells. -tissue_expression_ns hsa-mir-21 Myocardial Infarction 21956146 deregulated -tissue_expression_ns hsa-mir-29a Myocardial Infarction 21956146 deregulated -tissue_expression_ns hsa-mir-196a Breast Neoplasms 21962133 miR-196a has been reported to be aberrantly expressed in breast cancer tissue. -tissue_expression_ns hsa-mir-125a Gastric Neoplasms 21987613 "Five microRNAs (miR-125a-3p, miR-133b, miR-143, miR-195 and miR-212) were differently expressed between different metastatic groups in 30 gastric cancer biopsies (P < 0.05). Partial correlation analysis showed that hsa-mir-212 and hsa-mir-195 were correlated with the status of metastasis to LN in spite of age, gender, tumor location, tumor size, depth of invasion and cell differentiation. ROC analysis indicated that miR-212 and miR-195 have better sensitivities (84.6% and 69.2%, respectively) and specificities (both 100%) in distinguishing biopsies with metastasis to LN from biopsies without metastasis to LN." -tissue_expression_ns hsa-mir-133b Gastric Neoplasms 21987613 "Five microRNAs (miR-125a-3p, miR-133b, miR-143, miR-195 and miR-212) were differently expressed between different metastatic groups in 30 gastric cancer biopsies (P < 0.05). Partial correlation analysis showed that hsa-mir-212 and hsa-mir-195 were correlated with the status of metastasis to LN in spite of age, gender, tumor location, tumor size, depth of invasion and cell differentiation. ROC analysis indicated that miR-212 and miR-195 have better sensitivities (84.6% and 69.2%, respectively) and specificities (both 100%) in distinguishing biopsies with metastasis to LN from biopsies without metastasis to LN." -tissue_expression_ns hsa-mir-143 Gastric Neoplasms 21987613 "Five microRNAs (miR-125a-3p, miR-133b, miR-143, miR-195 and miR-212) were differently expressed between different metastatic groups in 30 gastric cancer biopsies (P < 0.05). Partial correlation analysis showed that hsa-mir-212 and hsa-mir-195 were correlated with the status of metastasis to LN in spite of age, gender, tumor location, tumor size, depth of invasion and cell differentiation. ROC analysis indicated that miR-212 and miR-195 have better sensitivities (84.6% and 69.2%, respectively) and specificities (both 100%) in distinguishing biopsies with metastasis to LN from biopsies without metastasis to LN." -tissue_expression_ns hsa-mir-195 Gastric Neoplasms 21987613 "Five microRNAs (miR-125a-3p, miR-133b, miR-143, miR-195 and miR-212) were differently expressed between different metastatic groups in 30 gastric cancer biopsies (P < 0.05). Partial correlation analysis showed that hsa-mir-212 and hsa-mir-195 were correlated with the status of metastasis to LN in spite of age, gender, tumor location, tumor size, depth of invasion and cell differentiation. ROC analysis indicated that miR-212 and miR-195 have better sensitivities (84.6% and 69.2%, respectively) and specificities (both 100%) in distinguishing biopsies with metastasis to LN from biopsies without metastasis to LN." -tissue_expression_ns hsa-mir-212 Gastric Neoplasms 21987613 "Five microRNAs (miR-125a-3p, miR-133b, miR-143, miR-195 and miR-212) were differently expressed between different metastatic groups in 30 gastric cancer biopsies (P < 0.05). Partial correlation analysis showed that hsa-mir-212 and hsa-mir-195 were correlated with the status of metastasis to LN in spite of age, gender, tumor location, tumor size, depth of invasion and cell differentiation. ROC analysis indicated that miR-212 and miR-195 have better sensitivities (84.6% and 69.2%, respectively) and specificities (both 100%) in distinguishing biopsies with metastasis to LN from biopsies without metastasis to LN." -tissue_expression_ns hsa-mir-130b "Tuberculosis, Pulmonary" 22003408 hsa-mir-130b*: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI). -tissue_expression_ns hsa-mir-144 "Tuberculosis, Pulmonary" 22003408 hsa-mir-144: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI). -tissue_expression_ns hsa-mir-155 "Tuberculosis, Pulmonary" 22003408 hsa-mir-155: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI). -tissue_expression_ns hsa-mir-181b-1 "Tuberculosis, Pulmonary" 22003408 hsa-mir-181b: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI). -tissue_expression_ns hsa-mir-181b-2 "Tuberculosis, Pulmonary" 22003408 hsa-mir-181b: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI). -tissue_expression_ns hsa-mir-21 "Tuberculosis, Pulmonary" 22003408 hsa-mir-21*: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI). -tissue_expression_ns hsa-mir-223 "Tuberculosis, Pulmonary" 22003408 hsa-mir-223: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI). -tissue_expression_ns hsa-mir-302a "Tuberculosis, Pulmonary" 22003408 hsa-mir-302a: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI). -tissue_expression_ns hsa-mir-329-1 "Tuberculosis, Pulmonary" 22003408 hsa-mir-329: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI). -tissue_expression_ns hsa-mir-329-2 "Tuberculosis, Pulmonary" 22003408 hsa-mir-329: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI). -tissue_expression_ns hsa-mir-342 "Tuberculosis, Pulmonary" 22003408 hsa-mir-342-5p: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI). -tissue_expression_ns hsa-mir-421 "Tuberculosis, Pulmonary" 22003408 hsa-mir-421: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI). -tissue_expression_ns hsa-mir-424 "Tuberculosis, Pulmonary" 22003408 hsa-mir-424: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI). -tissue_expression_ns hsa-mir-451a "Tuberculosis, Pulmonary" 22003408 hsa-mir-451: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI). -tissue_expression_ns hsa-mir-486 "Tuberculosis, Pulmonary" 22003408 hsa-mir-486-5p: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI). -tissue_expression_ns hsa-mir-520d "Tuberculosis, Pulmonary" 22003408 hsa-mir-520d-3p: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI). -tissue_expression_ns hsa-mir-548b "Tuberculosis, Pulmonary" 22003408 hsa-mir-548b-3p: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI). -tissue_expression_ns hsa-mir-550a-1 "Tuberculosis, Pulmonary" 22003408 hsa-mir-550*: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI). -tissue_expression_ns hsa-mir-550a-2 "Tuberculosis, Pulmonary" 22003408 hsa-mir-550*: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI). -tissue_expression_ns hsa-mir-550a-3 "Tuberculosis, Pulmonary" 22003408 hsa-mir-550*: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI). -tissue_expression_ns hsa-mir-550b-1 "Tuberculosis, Pulmonary" 22003408 hsa-mir-550*: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI). -tissue_expression_ns hsa-mir-550b-2 "Tuberculosis, Pulmonary" 22003408 hsa-mir-550*: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI). -tissue_expression_ns hsa-mir-640 "Tuberculosis, Pulmonary" 22003408 hsa-mir-640: differently expressed in the samples from study participants with active tuberculosis (TB) versus latent tuberculosis infection (LTBI). -tissue_expression_ns hsa-mir-516a-1 Frontotemporal Lobar Degeneration 22032330 miR-516a-3p was significantly dysregulated in frontal cortex and cerebellar tissue samples of PGRN mutation carriers. -tissue_expression_ns hsa-mir-516a-2 Frontotemporal Lobar Degeneration 22032330 miR-516a-3p was significantly dysregulated in frontal cortex and cerebellar tissue samples of PGRN mutation carriers. -tissue_expression_ns hsa-mir-548b Frontotemporal Lobar Degeneration 22032330 miR-548b-5p was significantly dysregulated in frontal cortex and cerebellar tissue samples of PGRN mutation carriers. -tissue_expression_ns hsa-mir-548c Frontotemporal Lobar Degeneration 22032330 miR-548c-5p was significantly dysregulated in frontal cortex and cerebellar tissue samples of PGRN mutation carriers. -tissue_expression_ns hsa-mir-571 Frontotemporal Lobar Degeneration 22032330 miR-571 was significantly dysregulated in frontal cortex and cerebellar tissue samples of PGRN mutation carriers. -tissue_expression_ns hsa-mir-922 Frontotemporal Lobar Degeneration 22032330 miR-922 was significantly dysregulated in frontal cortex and cerebellar tissue samples of PGRN mutation carriers. -tissue_expression_ns hsa-mir-126 "Carcinoma, Renal Cell" 22033272 The expression level of this miRNA was significantly altered in two independent cohorts of patients. -tissue_expression_ns hsa-mir-196a-1 "Carcinoma, Renal Cell" 22033272 The expression level of this miRNA was significantly altered in two independent cohorts of patients. -tissue_expression_ns hsa-mir-204 "Carcinoma, Renal Cell" 22033272 The expression level of this miRNA was significantly altered in two independent cohorts of patients. -tissue_expression_ns hsa-mir-215 "Carcinoma, Renal Cell" 22033272 "The expression level of this miRNA was significantly altered in two independent cohorts of patients. Overexpression of miR-215 decreased cellular migration and invasion in an RCC cell line model. In addition, through gene expression profiling, the authors identified direct and indirect targets of miR-215 that can contribute to tumour metastasis." -tissue_expression_ns hsa-mir-124-1 Rheumatoid Arthritis 22100329 deregulated -tissue_expression_ns hsa-mir-124-2 Rheumatoid Arthritis 22100329 deregulated -tissue_expression_ns hsa-mir-124-3 Rheumatoid Arthritis 22100329 deregulated -tissue_expression_ns hsa-mir-132 Rheumatoid Arthritis 22100329 deregulated -tissue_expression_ns hsa-mir-146a Rheumatoid Arthritis 22100329 deregulated -tissue_expression_ns hsa-mir-155 Rheumatoid Arthritis 22100329 deregulated -tissue_expression_ns hsa-mir-15a Rheumatoid Arthritis 22100329 deregulated -tissue_expression_ns hsa-mir-16-1 Rheumatoid Arthritis 22100329 deregulated -tissue_expression_ns hsa-mir-16-2 Rheumatoid Arthritis 22100329 deregulated -tissue_expression_ns hsa-mir-203 Rheumatoid Arthritis 22100329 deregulated -tissue_expression_ns hsa-mir-223 Rheumatoid Arthritis 22100329 deregulated -tissue_expression_ns hsa-mir-346 Rheumatoid Arthritis 22100329 deregulated -tissue_expression_ns hsa-mir-363 Rheumatoid Arthritis 22100329 deregulated -tissue_expression_ns hsa-mir-498 Rheumatoid Arthritis 22100329 deregulated -tissue_expression_ns hsa-let-7f-1 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-let-7f-2 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-let-7g Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-1-1 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-1-2 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-122 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-127 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-128-1 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-128-2 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-130a Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-132 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-140 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-146a Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-146b Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-155 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-16-1 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-16-2 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-181b-1 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-181b-2 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-182 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-183 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-185 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-186 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-193b Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-195 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-199b Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-206 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-223 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-224 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-26b Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-320a Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-328 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-340 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-342 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-34c Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-363 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-374a Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-374b Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-421 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-487b Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-497 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-503 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-513a-1 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-513a-2 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-513b Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-513c Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-515-1 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-515-2 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-516a-1 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-516a-2 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-516b-1 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-516b-2 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-517a Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-518f Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-519a-1 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-519a-2 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-519c Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-519e Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-520a Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-520d Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-524 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-526a-1 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-526a-2 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-577 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-591 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-595 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-601 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-629 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-640 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-658 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-661 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemoresistance -tissue_expression_ns hsa-mir-95 Gastric Neoplasms 22112324 A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of 82 cancer patients (P<0.05). This miRNA is associated with chemosensitivity -tissue_expression_ns hsa-mir-125b-1 Pancreatic Neoplasms 22114139 altered expression -tissue_expression_ns hsa-mir-125b-2 Pancreatic Neoplasms 22114139 altered expression -tissue_expression_ns hsa-mir-146a Pancreatic Neoplasms 22114139 altered expression -tissue_expression_ns hsa-mir-155 Pancreatic Neoplasms 22114139 altered expression -tissue_expression_ns hsa-mir-182 Pancreatic Neoplasms 22114139 altered expression -tissue_expression_ns hsa-mir-183 Pancreatic Neoplasms 22114139 miR-183*:altered expression -tissue_expression_ns hsa-mir-196b Pancreatic Neoplasms 22114139 altered expression -tissue_expression_ns hsa-mir-200a Pancreatic Neoplasms 22114139 altered expression -tissue_expression_ns hsa-mir-200b Pancreatic Neoplasms 22114139 altered expression -tissue_expression_ns hsa-mir-200c Pancreatic Neoplasms 22114139 altered expression -tissue_expression_ns hsa-mir-203 Pancreatic Neoplasms 22114139 altered expression -tissue_expression_ns hsa-mir-21 Pancreatic Neoplasms 22114139 altered expression -tissue_expression_ns hsa-mir-216a Pancreatic Neoplasms 22114139 altered expression -tissue_expression_ns hsa-mir-216b Pancreatic Neoplasms 22114139 altered expression -tissue_expression_ns hsa-mir-217 Pancreatic Neoplasms 22114139 altered expression -tissue_expression_ns hsa-mir-222 Pancreatic Neoplasms 22114139 altered expression -tissue_expression_ns hsa-mir-296 Pancreatic Neoplasms 22114139 miR-296-5p:altered expression -tissue_expression_ns hsa-mir-338 Pancreatic Neoplasms 22114139 miR-338-3p;altered expression -tissue_expression_ns hsa-mir-486 Pancreatic Neoplasms 22114139 miR-486-3p:altered expression -tissue_expression_ns hsa-mir-603 Pancreatic Neoplasms 22114139 altered expression -tissue_expression_ns hsa-mir-625 Pancreatic Neoplasms 22114139 miR-625*:altered expression -tissue_expression_ns hsa-mir-708 Pancreatic Neoplasms 22114139 altered expression -tissue_expression_ns hsa-mir-10a Urinary Bladder Cancer 22140553 deregulated -tissue_expression_ns hsa-mir-1-1 Urinary Bladder Cancer 22140553 deregulated -tissue_expression_ns hsa-mir-1-2 Urinary Bladder Cancer 22140553 deregulated -tissue_expression_ns hsa-mir-125b-1 Urinary Bladder Cancer 22140553 deregulated -tissue_expression_ns hsa-mir-125b-2 Urinary Bladder Cancer 22140553 deregulated -tissue_expression_ns hsa-mir-133a-1 Urinary Bladder Cancer 22140553 deregulated -tissue_expression_ns hsa-mir-133a-2 Urinary Bladder Cancer 22140553 deregulated -tissue_expression_ns hsa-mir-133b Urinary Bladder Cancer 22140553 deregulated -tissue_expression_ns hsa-mir-143 Urinary Bladder Cancer 22140553 deregulated -tissue_expression_ns hsa-mir-145 Urinary Bladder Cancer 22140553 deregulated -tissue_expression_ns hsa-mir-182 Urinary Bladder Cancer 22140553 deregulated -tissue_expression_ns hsa-mir-183 Urinary Bladder Cancer 22140553 deregulated -tissue_expression_ns hsa-mir-203 Urinary Bladder Cancer 22140553 deregulated -tissue_expression_ns hsa-mir-224 Urinary Bladder Cancer 22140553 deregulated -tissue_expression_ns hsa-mir-1-1 Prostate Neoplasms 22210864 MicroRNA-1 is a candidate tumor suppressor and prognostic marker in human prostate cancer. -tissue_expression_ns hsa-mir-1-2 Prostate Neoplasms 22210864 MicroRNA-1 is a candidate tumor suppressor and prognostic marker in human prostate cancer. -tissue_expression_ns hsa-let-7b Breast Neoplasms 22294324 "let-7b expression was shown to be associated with luminal tumours, and to have an independent significant positive prognostic value in this group. miR-205 is associated with tumours of ductal morphology, and is of significant positive prognostic value within these tumours." -tissue_expression_ns hsa-mir-205 Breast Neoplasms 22294324 "let-7b expression was shown to be associated with luminal tumours, and to have an independent significant positive prognostic value in this group. miR-205 is associated with tumours of ductal morphology, and is of significant positive prognostic value within these tumours." -tissue_expression_ns hsa-mir-146a Lupus Nephritis 22295894 "Intra-renal expression of miR-638, miR-198 and miR-146a are differentially expressed between LN patients and normal controls. Furthermore, the degree of change in glomerular miR-146a and tubulointerstitial miR-638 expression correlated with clinical disease severity." -tissue_expression_ns hsa-mir-198 Lupus Nephritis 22295894 "Intra-renal expression of miR-638, miR-198 and miR-146a are differentially expressed between LN patients and normal controls. Furthermore, the degree of change in glomerular miR-146a and tubulointerstitial miR-638 expression correlated with clinical disease severity." -tissue_expression_ns hsa-mir-638 Lupus Nephritis 22295894 "Intra-renal expression of miR-638, miR-198 and miR-146a are differentially expressed between LN patients and normal controls. Furthermore, the degree of change in glomerular miR-146a and tubulointerstitial miR-638 expression correlated with clinical disease severity." -tissue_expression_ns hsa-mir-145 "Scleroderma, Systemic" 22307526 The expression of the miRNA was correlated with Systemic Scleroderma fibrosis -tissue_expression_ns hsa-mir-146a "Scleroderma, Systemic" 22307526 The expression of the miRNA was correlated with Systemic Scleroderma fibrosis -tissue_expression_ns hsa-mir-146b "Scleroderma, Systemic" 22307526 The expression of the miRNA was correlated with Systemic Scleroderma fibrosis -tissue_expression_ns hsa-mir-21 "Scleroderma, Systemic" 22307526 The expression of the miRNA was correlated with Systemic Scleroderma fibrosis -tissue_expression_ns hsa-mir-29b-1 "Scleroderma, Systemic" 22307526 The expression of the miRNA was correlated with Systemic Scleroderma fibrosis -tissue_expression_ns hsa-mir-29b-2 "Scleroderma, Systemic" 22307526 The expression of the miRNA was correlated with Systemic Scleroderma fibrosis -tissue_expression_ns hsa-mir-31 "Scleroderma, Systemic" 22307526 The expression of the miRNA was correlated with Systemic Scleroderma fibrosis -tissue_expression_ns hsa-mir-503 "Scleroderma, Systemic" 22307526 The expression of the miRNA was correlated with Systemic Scleroderma fibrosis -tissue_expression_ns hsa-let-7i Breast Neoplasms 22315424 "Five noncoding genes were associated with both prognostic signatures-miR-210, -21, -106b*, -197, and let-7i, with miR-210 the only one also involved in the invasive transition." -tissue_expression_ns hsa-mir-106b Breast Neoplasms 22315424 "Five noncoding genes were associated with both prognostic signatures-miR-210, -21, -106b*, -197, and let-7i, with miR-210 the only one also involved in the invasive transition." -tissue_expression_ns hsa-mir-197 Breast Neoplasms 22315424 "Five noncoding genes were associated with both prognostic signatures-miR-210, -21, -106b*, -197, and let-7i, with miR-210 the only one also involved in the invasive transition." -tissue_expression_ns hsa-mir-21 Breast Neoplasms 22315424 "Five noncoding genes were associated with both prognostic signatures-miR-210, -21, -106b*, -197, and let-7i, with miR-210 the only one also involved in the invasive transition." -tissue_expression_ns hsa-mir-10b "Carcinoma, Oral" 22318752 hsa-mir-10b has the potential for Oncogenic Function and Early Detection in Oral Cancer as Identified by microRNA Profiling. -tissue_expression_ns hsa-mir-100 Urinary Bladder Cancer 22330141 "Altered expression of five significantly differentially expressed miRNAs, hsa-miR-9 (1q23.2), hsa-miR-15b (3q25.32), hsa-miR-28-5p (3q27.3), hsa-miR-100 and hsa-miR-125b (both 11q24.1), was directly linked to frequent chromosomal alterations." -tissue_expression_ns hsa-mir-125b-1 Urinary Bladder Cancer 22330141 "Altered expression of five significantly differentially expressed miRNAs, hsa-miR-9 (1q23.2), hsa-miR-15b (3q25.32), hsa-miR-28-5p (3q27.3), hsa-miR-100 and hsa-miR-125b (both 11q24.1), was directly linked to frequent chromosomal alterations." -tissue_expression_ns hsa-mir-15b Urinary Bladder Cancer 22330141 "Altered expression of five significantly differentially expressed miRNAs, hsa-miR-9 (1q23.2), hsa-miR-15b (3q25.32), hsa-miR-28-5p (3q27.3), hsa-miR-100 and hsa-miR-125b (both 11q24.1), was directly linked to frequent chromosomal alterations." -tissue_expression_ns hsa-mir-28 Urinary Bladder Cancer 22330141 "Altered expression of five significantly differentially expressed miRNAs, hsa-miR-9 (1q23.2), hsa-miR-15b (3q25.32), hsa-miR-28-5p (3q27.3), hsa-miR-100 and hsa-miR-125b (both 11q24.1), was directly linked to frequent chromosomal alterations." -tissue_expression_ns hsa-mir-9-1 Urinary Bladder Cancer 22330141 "Altered expression of five significantly differentially expressed miRNAs, hsa-miR-9 (1q23.2), hsa-miR-15b (3q25.32), hsa-miR-28-5p (3q27.3), hsa-miR-100 and hsa-miR-125b (both 11q24.1), was directly linked to frequent chromosomal alterations." -tissue_expression_ns hsa-mir-15b "Carcinoma, Lung, Non-Small-Cell" 22389695 "A combination of two differentially expressed miRNAs miR-15b and miR-27b, was able to discriminate NSCLC from healthy controls with sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 100% in the training set." -tissue_expression_ns hsa-mir-27b "Carcinoma, Lung, Non-Small-Cell" 22389695 "A combination of two differentially expressed miRNAs miR-15b and miR-27b, was able to discriminate NSCLC from healthy controls with sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 100% in the training set." -tissue_expression_ns hsa-mir-124-1 Lymphoma 22395483 "A distinct set of five microRNAs (miR-150, miR-550, miR-124a, miR-518b and miR-539) was shown to be differentially expressed in gastritis as opposed to MALT lymphoma." -tissue_expression_ns hsa-mir-150 Lymphoma 22395483 "A distinct set of five microRNAs (miR-150, miR-550, miR-124a, miR-518b and miR-539) was shown to be differentially expressed in gastritis as opposed to MALT lymphoma." -tissue_expression_ns hsa-mir-518b Lymphoma 22395483 "A distinct set of five microRNAs (miR-150, miR-550, miR-124a, miR-518b and miR-539) was shown to be differentially expressed in gastritis as opposed to MALT lymphoma." -tissue_expression_ns hsa-mir-539 Lymphoma 22395483 "A distinct set of five microRNAs (miR-150, miR-550, miR-124a, miR-518b and miR-539) was shown to be differentially expressed in gastritis as opposed to MALT lymphoma." -tissue_expression_ns hsa-mir-550a-1 Lymphoma 22395483 "A distinct set of five microRNAs (miR-150, miR-550, miR-124a, miR-518b and miR-539) was shown to be differentially expressed in gastritis as opposed to MALT lymphoma." -tissue_expression_ns hsa-mir-550a-2 Lymphoma 22395483 "A distinct set of five microRNAs (miR-150, miR-550, miR-124a, miR-518b and miR-539) was shown to be differentially expressed in gastritis as opposed to MALT lymphoma." -tissue_expression_ns hsa-mir-143 Urinary Bladder Cancer 22426337 "miR-143, miR-222, and miR-452 Are Useful as Tumor Stratification and Noninvasive Diagnostic Biomarkers for Bladder Cancer." -tissue_expression_ns hsa-mir-222 Urinary Bladder Cancer 22426337 "miR-143, miR-222, and miR-452 Are Useful as Tumor Stratification and Noninvasive Diagnostic Biomarkers for Bladder Cancer." -tissue_expression_ns hsa-mir-452 Urinary Bladder Cancer 22426337 "miR-143, miR-222, and miR-452 Are Useful as Tumor Stratification and Noninvasive Diagnostic Biomarkers for Bladder Cancer." -tissue_expression_ns hsa-mir-199b Heart Failure 22427379 "Six miRNAs were differently expressed when comparing D-HF (diabetic HF) and ND-HF (nondiabetic HF) patients: miR-34b, miR-34c, miR-199b, miR-210, miR-650, and miR-223." -tissue_expression_ns hsa-mir-210 Heart Failure 22427379 "Six miRNAs were differently expressed when comparing D-HF (diabetic HF) and ND-HF (nondiabetic HF) patients: miR-34b, miR-34c, miR-199b, miR-210, miR-650, and miR-223." -tissue_expression_ns hsa-mir-223 Heart Failure 22427379 "Six miRNAs were differently expressed when comparing D-HF (diabetic HF) and ND-HF (nondiabetic HF) patients: miR-34b, miR-34c, miR-199b, miR-210, miR-650, and miR-223." -tissue_expression_ns hsa-mir-34b Heart Failure 22427379 "Six miRNAs were differently expressed when comparing D-HF (diabetic HF) and ND-HF (nondiabetic HF) patients: miR-34b, miR-34c, miR-199b, miR-210, miR-650, and miR-223." -tissue_expression_ns hsa-mir-34c Heart Failure 22427379 "Six miRNAs were differently expressed when comparing D-HF (diabetic HF) and ND-HF (nondiabetic HF) patients: miR-34b, miR-34c, miR-199b, miR-210, miR-650, and miR-223." -tissue_expression_ns hsa-mir-650 Heart Failure 22427379 "Six miRNAs were differently expressed when comparing D-HF (diabetic HF) and ND-HF (nondiabetic HF) patients: miR-34b, miR-34c, miR-199b, miR-210, miR-650, and miR-223." -tissue_expression_ns hsa-mir-106b Ewing Sarcoma 22429812 "MiR-21, miR-31, miR-31*, miR-106b, miR-145, miR-150*, miR-371-5p, miR-557 and miR-598 showed recurrently altered expression." -tissue_expression_ns hsa-mir-145 Ewing Sarcoma 22429812 "MiR-21, miR-31, miR-31*, miR-106b, miR-145, miR-150*, miR-371-5p, miR-557 and miR-598 showed recurrently altered expression." -tissue_expression_ns hsa-mir-150 Ewing Sarcoma 22429812 "MiR-21, miR-31, miR-31*, miR-106b, miR-145, miR-150*, miR-371-5p, miR-557 and miR-598 showed recurrently altered expression." -tissue_expression_ns hsa-mir-21 Ewing Sarcoma 22429812 "MiR-21, miR-31, miR-31*, miR-106b, miR-145, miR-150*, miR-371-5p, miR-557 and miR-598 showed recurrently altered expression." -tissue_expression_ns hsa-mir-31 Ewing Sarcoma 22429812 "MiR-21, miR-31, miR-31*, miR-106b, miR-145, miR-150*, miR-371-5p, miR-557 and miR-598 showed recurrently altered expression." -tissue_expression_ns hsa-mir-371a Ewing Sarcoma 22429812 "MiR-21, miR-31, miR-31*, miR-106b, miR-145, miR-150*, miR-371-5p, miR-557 and miR-598 showed recurrently altered expression." -tissue_expression_ns hsa-mir-557 Ewing Sarcoma 22429812 "MiR-21, miR-31, miR-31*, miR-106b, miR-145, miR-150*, miR-371-5p, miR-557 and miR-598 showed recurrently altered expression." -tissue_expression_ns hsa-mir-598 Ewing Sarcoma 22429812 "MiR-21, miR-31, miR-31*, miR-106b, miR-145, miR-150*, miR-371-5p, miR-557 and miR-598 showed recurrently altered expression." -tissue_expression_ns hsa-mir-137 Leiomyoma 22446413 deregulated -tissue_expression_ns hsa-mir-217 Leiomyoma 22446413 deregulated -tissue_expression_ns hsa-mir-363 Leiomyoma 22446413 deregulated -tissue_expression_ns hsa-mir-4792 Leiomyoma 22446413 deregulated -tissue_expression_ns hsa-mir-490 Leiomyoma 22446413 deregulated -tissue_expression_ns hsa-mir-135a-1 Lymphoma 22490335 different expression between small lymphocytic leukemia and lymphoma -tissue_expression_ns hsa-mir-135a-2 Lymphoma 22490335 different expression between small lymphocytic leukemia and lymphoma -tissue_expression_ns hsa-mir-150 Lymphoma 22490335 different expression between small lymphocytic leukemia and lymphoma -tissue_expression_ns hsa-mir-184 Lymphoma 22490335 different expression between small lymphocytic leukemia and lymphoma -tissue_expression_ns hsa-mir-342 Lymphoma 22490335 different expression between small lymphocytic leukemia and lymphoma -tissue_expression_ns hsa-mir-363 Lymphoma 22490335 different expression between small lymphocytic leukemia and lymphoma -tissue_expression_ns hsa-mir-708 Lymphoma 22490335 different expression between small lymphocytic leukemia and lymphoma -tissue_expression_ns hsa-mir-103 Lung Neoplasms 22576802 "Among them, some have a well-characterized association with cancer progression, e.g. miR-125b, miR-210, miR-103, miR-194 and miR-500. In summary, it is evident from our results that MTA1 functions in regulating the invasive phenotype of lung cancer cells and this regulation may be through altered miRNA expression." -tissue_expression_ns hsa-mir-125b Lung Neoplasms 22576802 "Among them, some have a well-characterized association with cancer progression, e.g. miR-125b, miR-210, miR-103, miR-194 and miR-500. In summary, it is evident from our results that MTA1 functions in regulating the invasive phenotype of lung cancer cells and this regulation may be through altered miRNA expression." -tissue_expression_ns hsa-mir-194 Lung Neoplasms 22576802 "Among them, some have a well-characterized association with cancer progression, e.g. miR-125b, miR-210, miR-103, miR-194 and miR-500. In summary, it is evident from our results that MTA1 functions in regulating the invasive phenotype of lung cancer cells and this regulation may be through altered miRNA expression." -tissue_expression_ns hsa-mir-210 Lung Neoplasms 22576802 "Among them, some have a well-characterized association with cancer progression, e.g. miR-125b, miR-210, miR-103, miR-194 and miR-500. In summary, it is evident from our results that MTA1 functions in regulating the invasive phenotype of lung cancer cells and this regulation may be through altered miRNA expression." -tissue_expression_ns hsa-mir-500 Lung Neoplasms 22576802 "Among them, some have a well-characterized association with cancer progression, e.g. miR-125b, miR-210, miR-103, miR-194 and miR-500. In summary, it is evident from our results that MTA1 functions in regulating the invasive phenotype of lung cancer cells and this regulation may be through altered miRNA expression." -tissue_expression_ns hsa-mir-182 "Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic" 22582938 Aberrant microRNA-182 expression is associated with glucocorticoid resistance in lymphoblastic malignancies. -tissue_expression_ns hsa-mir-10b "Carcinoma, Renal Cell" 22623952 "The expression levels of miR-10b, miR-139-5p, miR-130b and miR-199b-5p could determine the status of ccRCC metastasis." -tissue_expression_ns hsa-mir-130b "Carcinoma, Renal Cell" 22623952 "The expression levels of miR-10b, miR-139-5p, miR-130b and miR-199b-5p could determine the status of ccRCC metastasis." -tissue_expression_ns hsa-mir-139 "Carcinoma, Renal Cell" 22623952 "The expression levels of miR-10b, miR-139-5p, miR-130b and miR-199b-5p could determine the status of ccRCC metastasis." -tissue_expression_ns hsa-mir-195 "Carcinoma, Renal Cell" 22623952 "The expression levels of miR-10b, miR-139-5p, miR-130b and miR-199b-5p could determine the status of ccRCC metastasis." -tissue_expression_ns hsa-mir-199b "Carcinoma, Renal Cell" 22623952 "The expression levels of miR-10b, miR-139-5p, miR-130b and miR-199b-5p could determine the status of ccRCC metastasis." -tissue_expression_ns hsa-mir-205 Breast Neoplasms 22631664 miR-205 and miR-342 may be used as potential biomarkers for diagnosis of triple negative breast cancer. -tissue_expression_ns hsa-mir-342 Breast Neoplasms 22631664 miR-205 and miR-342 may be used as potential biomarkers for diagnosis of triple negative breast cancer. -tissue_expression_ns hsa-mir-100 Urinary Bladder Cancer 22644299 differential expression in urinary samples -tissue_expression_ns hsa-mir-1224 Urinary Bladder Cancer 22644299 differential expression in urinary samples -tissue_expression_ns hsa-mir-135b Urinary Bladder Cancer 22644299 differential expression in urinary samples -tissue_expression_ns hsa-mir-15a Urinary Bladder Cancer 22644299 differential expression in urinary samples -tissue_expression_ns hsa-mir-15b Urinary Bladder Cancer 22644299 differential expression in urinary samples -tissue_expression_ns hsa-mir-203 Urinary Bladder Cancer 22644299 differential expression in urinary samples -tissue_expression_ns hsa-mir-212 Urinary Bladder Cancer 22644299 differential expression in urinary samples -tissue_expression_ns hsa-mir-24-1 Urinary Bladder Cancer 22644299 differential expression in urinary samples -tissue_expression_ns hsa-mir-27b Urinary Bladder Cancer 22644299 differential expression in urinary samples -tissue_expression_ns hsa-mir-328 Urinary Bladder Cancer 22644299 differential expression in urinary samples -tissue_expression_ns hsa-mir-574 Gastric Neoplasms 22683180 miR-574-3p: Aberrant expression -tissue_expression_ns hsa-mir-125a Head And Neck Neoplasms 22690848 Differential expression -tissue_expression_ns hsa-mir-125b-1 Head And Neck Neoplasms 22690848 Differential expression -tissue_expression_ns hsa-mir-125b-2 Head And Neck Neoplasms 22690848 Differential expression -tissue_expression_ns hsa-mir-203 Head And Neck Neoplasms 22690848 Differential expression -tissue_expression_ns hsa-mir-21 Head And Neck Neoplasms 22690848 Differential expression -tissue_expression_ns hsa-mir-31 Head And Neck Neoplasms 22690848 Differential expression -tissue_expression_ns hsa-mir-199a "Carcinoma, Hepatocellular" 22714032 "the expression of miR-21, miR-221, miR-222 and miR-199a showing characteristic alterations in hepatocellular carcinoma also displayed deregulated expressions in these two early stages." -tissue_expression_ns hsa-mir-21 "Carcinoma, Hepatocellular" 22714032 "the expression of miR-21, miR-221, miR-222 and miR-199a showing characteristic alterations in hepatocellular carcinoma also displayed deregulated expressions in these two early stages." -tissue_expression_ns hsa-mir-221 "Carcinoma, Hepatocellular" 22714032 "the expression of miR-21, miR-221, miR-222 and miR-199a showing characteristic alterations in hepatocellular carcinoma also displayed deregulated expressions in these two early stages." -tissue_expression_ns hsa-mir-222 "Carcinoma, Hepatocellular" 22714032 "the expression of miR-21, miR-221, miR-222 and miR-199a showing characteristic alterations in hepatocellular carcinoma also displayed deregulated expressions in these two early stages." -tissue_expression_ns hsa-mir-155 Lymphoma 22776000 "Although miRNA microarray analysis did not identify statistically significant differentially expressed miRNAs, miRNA-Q-PCR demonstrated statistically significantly differential expression of miR-155, miR-27b, miR-93, miR-29b and miR-92a between tumor-stage MF and C-ALCL." -tissue_expression_ns hsa-mir-27b Lymphoma 22776000 "Although miRNA microarray analysis did not identify statistically significant differentially expressed miRNAs, miRNA-Q-PCR demonstrated statistically significantly differential expression of miR-155, miR-27b, miR-93, miR-29b and miR-92a between tumor-stage MF and C-ALCL." -tissue_expression_ns hsa-mir-29b Lymphoma 22776000 "Although miRNA microarray analysis did not identify statistically significant differentially expressed miRNAs, miRNA-Q-PCR demonstrated statistically significantly differential expression of miR-155, miR-27b, miR-93, miR-29b and miR-92a between tumor-stage MF and C-ALCL." -tissue_expression_ns hsa-mir-92a Lymphoma 22776000 "Although miRNA microarray analysis did not identify statistically significant differentially expressed miRNAs, miRNA-Q-PCR demonstrated statistically significantly differential expression of miR-155, miR-27b, miR-93, miR-29b and miR-92a between tumor-stage MF and C-ALCL." -tissue_expression_ns hsa-mir-93 Lymphoma 22776000 "Although miRNA microarray analysis did not identify statistically significant differentially expressed miRNAs, miRNA-Q-PCR demonstrated statistically significantly differential expression of miR-155, miR-27b, miR-93, miR-29b and miR-92a between tumor-stage MF and C-ALCL." -tissue_expression_ns hsa-mir-10a Urinary Bladder Cancer 22801550 differentially expressed -tissue_expression_ns hsa-mir-193b Urinary Bladder Cancer 22801550 differentially expressed -tissue_expression_ns hsa-mir-203 Urinary Bladder Cancer 22801550 differentially expressed -tissue_expression_ns hsa-mir-20b Urinary Bladder Cancer 22801550 differentially expressed -tissue_expression_ns hsa-mir-338 Urinary Bladder Cancer 22801550 differentially expressed -tissue_expression_ns hsa-mir-345 Urinary Bladder Cancer 22801550 differentially expressed -tissue_expression_ns hsa-mir-34b Urinary Bladder Cancer 22801550 differentially expressed -tissue_expression_ns hsa-mir-34c Urinary Bladder Cancer 22801550 differentially expressed -tissue_expression_ns hsa-mir-424 Urinary Bladder Cancer 22801550 differentially expressed -tissue_expression_ns hsa-mir-512-1 Urinary Bladder Cancer 22801550 differentially expressed -tissue_expression_ns hsa-mir-512-2 Urinary Bladder Cancer 22801550 differentially expressed -tissue_expression_ns hsa-mir-518a-1 Urinary Bladder Cancer 22801550 differentially expressed -tissue_expression_ns hsa-mir-518a-2 Urinary Bladder Cancer 22801550 differentially expressed -tissue_expression_ns hsa-mir-9-1 Urinary Bladder Cancer 22801550 differentially expressed -tissue_expression_ns hsa-mir-9-2 Urinary Bladder Cancer 22801550 differentially expressed -tissue_expression_ns hsa-mir-9-3 Urinary Bladder Cancer 22801550 differentially expressed -tissue_expression_ns hsa-mir-143 Pancreatic Neoplasms 22836856 Changes in miR-143 and miR-21 Expression are correlated with Clinicopathology in Pancreatic Cancers. -tissue_expression_ns hsa-mir-21 Pancreatic Neoplasms 22836856 Changes in miR-143 and miR-21 Expression are correlated with Clinicopathology in Pancreatic Cancers. -tissue_expression_ns hsa-mir-128-1 Glioblastoma 22844109 "Expression of miR-128a, -504, -124a, and -184 each negatively correlated with the expression of mesenchymal markers in GBM." -tissue_expression_ns hsa-mir-128-2 Glioblastoma 22844109 "Expression of miR-128a, -504, -124a, and -184 each negatively correlated with the expression of mesenchymal markers in GBM." -tissue_expression_ns hsa-mir-184 Glioblastoma 22844109 "Expression of miR-128a, -504, -124a, and -184 each negatively correlated with the expression of mesenchymal markers in GBM." -tissue_expression_ns hsa-mir-504 Glioblastoma 22844109 "Expression of miR-128a, -504, -124a, and -184 each negatively correlated with the expression of mesenchymal markers in GBM." -tissue_expression_ns hsa-mir-135b Colorectal Carcinoma 22844381 "Expression of miR-21, miR-31, miR-96 and miR-135b is correlated with the clinical parameters of colorectal cancer." -tissue_expression_ns hsa-mir-21 Colorectal Carcinoma 22844381 "Expression of miR-21, miR-31, miR-96 and miR-135b is correlated with the clinical parameters of colorectal cancer." -tissue_expression_ns hsa-mir-31 Colorectal Carcinoma 22844381 "Expression of miR-21, miR-31, miR-96 and miR-135b is correlated with the clinical parameters of colorectal cancer." -tissue_expression_ns hsa-mir-96 Colorectal Carcinoma 22844381 "Expression of miR-21, miR-31, miR-96 and miR-135b is correlated with the clinical parameters of colorectal cancer." -tissue_expression_ns hsa-mir-144 Colorectal Carcinoma 22850566 differentially expressed -tissue_expression_ns hsa-mir-147b Colorectal Carcinoma 22850566 differentially expressed -tissue_expression_ns hsa-mir-148a Colorectal Carcinoma 22850566 differentially expressed -tissue_expression_ns hsa-mir-190a Colorectal Carcinoma 22850566 differentially expressed -tissue_expression_ns hsa-mir-2110 Colorectal Carcinoma 22850566 differentially expressed -tissue_expression_ns hsa-mir-26a-1 Colorectal Carcinoma 22850566 differentially expressed -tissue_expression_ns hsa-mir-26a-2 Colorectal Carcinoma 22850566 differentially expressed -tissue_expression_ns hsa-mir-26b Colorectal Carcinoma 22850566 differentially expressed -tissue_expression_ns hsa-mir-338 Colorectal Carcinoma 22850566 miR-338-3p: differentially expressed -tissue_expression_ns hsa-mir-375 Colorectal Carcinoma 22850566 differentially expressed -tissue_expression_ns hsa-mir-483 Colorectal Carcinoma 22850566 miR-483-5p: differentially expressed -tissue_expression_ns hsa-mir-492 Colorectal Carcinoma 22850566 differentially expressed -tissue_expression_ns hsa-mir-542 Colorectal Carcinoma 22850566 miR-542-5p: differentially expressed -tissue_expression_ns hsa-mir-584 Colorectal Carcinoma 22850566 differentially expressed -tissue_expression_ns hsa-mir-652 Colorectal Carcinoma 22850566 differentially expressed -tissue_expression_ns hsa-mir-183 Esophageal Neoplasms 22891887 "The relative expressions of miR-155, miR-183, and miR-20a in esophageal tissue were found to be significantly associated with increased risk for esophageal cancer." -tissue_expression_ns hsa-mir-20a Esophageal Neoplasms 22891887 "The relative expressions of miR-155, miR-183, and miR-20a in esophageal tissue were found to be significantly associated with increased risk for esophageal cancer." -tissue_expression_ns hsa-mir-106a Inflammatory Bowel Diseases 22899284 "A significant difference in expressions of miR-19b, miR-106a, and miR-629 was detected between ulcerative colitis and Crohns disease groups (P<0.05)." -tissue_expression_ns hsa-mir-19b-1 Inflammatory Bowel Diseases 22899284 "A significant difference in expressions of miR-19b, miR-106a, and miR-629 was detected between ulcerative colitis and Crohns disease groups (P<0.05)." -tissue_expression_ns hsa-mir-19b-2 Inflammatory Bowel Diseases 22899284 "A significant difference in expressions of miR-19b, miR-106a, and miR-629 was detected between ulcerative colitis and Crohns disease groups (P<0.05)." -tissue_expression_ns hsa-mir-629 Inflammatory Bowel Diseases 22899284 "A significant difference in expressions of miR-19b, miR-106a, and miR-629 was detected between ulcerative colitis and Crohns disease groups (P<0.05)." -tissue_expression_ns hsa-mir-181d Ovarian Neoplasms 22925189 "Expression of four miRNAs (miR-30c, miR-30d, miR-30e-3p, miR-370) was significantly different between carcinomas and benign ovarian tissues as well as between carcinoma and borderline tissues. An additional three miRNAs (miR-181d, miR-30a-3p, miR-532-5p) were significantly different between borderline and carcinoma tissues." -tissue_expression_ns hsa-mir-30a Ovarian Neoplasms 22925189 "Expression of four miRNAs (miR-30c, miR-30d, miR-30e-3p, miR-370) was significantly different between carcinomas and benign ovarian tissues as well as between carcinoma and borderline tissues. An additional three miRNAs (miR-181d, miR-30a-3p, miR-532-5p) were significantly different between borderline and carcinoma tissues." -tissue_expression_ns hsa-mir-30c-1 Ovarian Neoplasms 22925189 "Expression of four miRNAs (miR-30c, miR-30d, miR-30e-3p, miR-370) was significantly different between carcinomas and benign ovarian tissues as well as between carcinoma and borderline tissues. An additional three miRNAs (miR-181d, miR-30a-3p, miR-532-5p) were significantly different between borderline and carcinoma tissues." -tissue_expression_ns hsa-mir-30c-2 Ovarian Neoplasms 22925189 "Expression of four miRNAs (miR-30c, miR-30d, miR-30e-3p, miR-370) was significantly different between carcinomas and benign ovarian tissues as well as between carcinoma and borderline tissues. An additional three miRNAs (miR-181d, miR-30a-3p, miR-532-5p) were significantly different between borderline and carcinoma tissues." -tissue_expression_ns hsa-mir-30d Ovarian Neoplasms 22925189 "Expression of four miRNAs (miR-30c, miR-30d, miR-30e-3p, miR-370) was significantly different between carcinomas and benign ovarian tissues as well as between carcinoma and borderline tissues. An additional three miRNAs (miR-181d, miR-30a-3p, miR-532-5p) were significantly different between borderline and carcinoma tissues." -tissue_expression_ns hsa-mir-30e Ovarian Neoplasms 22925189 "Expression of four miRNAs (miR-30c, miR-30d, miR-30e-3p, miR-370) was significantly different between carcinomas and benign ovarian tissues as well as between carcinoma and borderline tissues. An additional three miRNAs (miR-181d, miR-30a-3p, miR-532-5p) were significantly different between borderline and carcinoma tissues." -tissue_expression_ns hsa-mir-370 Ovarian Neoplasms 22925189 "Expression of four miRNAs (miR-30c, miR-30d, miR-30e-3p, miR-370) was significantly different between carcinomas and benign ovarian tissues as well as between carcinoma and borderline tissues. An additional three miRNAs (miR-181d, miR-30a-3p, miR-532-5p) were significantly different between borderline and carcinoma tissues." -tissue_expression_ns hsa-mir-532 Ovarian Neoplasms 22925189 "Expression of four miRNAs (miR-30c, miR-30d, miR-30e-3p, miR-370) was significantly different between carcinomas and benign ovarian tissues as well as between carcinoma and borderline tissues. An additional three miRNAs (miR-181d, miR-30a-3p, miR-532-5p) were significantly different between borderline and carcinoma tissues." -tissue_expression_ns hsa-mir-126 Coronary Artery Disease 22925274 "MiR-126 was not significantly down-regulated or up-regulated in CAD patients. Interestingly, the level of miR-126 was significantly decreased in patients with CAD and high low-density lipoprotein (LDL) cholesterol level. In contrast, the level of miR-126 was significantly increased when LDL cholesterol was high in patients who had risk factors for CAD but did not have angiographically significant CAD." -tissue_expression_ns hsa-mir-182 "Shock, Septic" 22940033 "We confirmed expression of select miRNAs (miR-182, -199a-5p, -203, -211, -222, and -29b) using quantitative reverse transcriptase-polymerase chain reaction." -tissue_expression_ns hsa-mir-199a "Shock, Septic" 22940033 "We confirmed expression of select miRNAs (miR-182, -199a-5p, -203, -211, -222, and -29b) using quantitative reverse transcriptase-polymerase chain reaction." -tissue_expression_ns hsa-mir-203 "Shock, Septic" 22940033 "We confirmed expression of select miRNAs (miR-182, -199a-5p, -203, -211, -222, and -29b) using quantitative reverse transcriptase-polymerase chain reaction." -tissue_expression_ns hsa-mir-211 "Shock, Septic" 22940033 "We confirmed expression of select miRNAs (miR-182, -199a-5p, -203, -211, -222, and -29b) using quantitative reverse transcriptase-polymerase chain reaction." -tissue_expression_ns hsa-mir-222 "Shock, Septic" 22940033 "We confirmed expression of select miRNAs (miR-182, -199a-5p, -203, -211, -222, and -29b) using quantitative reverse transcriptase-polymerase chain reaction." -tissue_expression_ns hsa-mir-29b "Shock, Septic" 22940033 "We confirmed expression of select miRNAs (miR-182, -199a-5p, -203, -211, -222, and -29b) using quantitative reverse transcriptase-polymerase chain reaction." -tissue_expression_ns hsa-mir-145 Bladder Neoplasms 22961325 Assessment of miR-145 levels was able to distinguish bladder cancer patients from non-cancer controls -tissue_expression_ns hsa-let-7b Breast Neoplasms 22976804 "By means of RT-qPCR, we further investigated miRNA expression in more IMPC (n?=?22) and IDC-NSTs (n?=?24) FFPE samples and found let-7b, miR-30c, miR-148a, miR-181a, miR-181a*, and miR-181b were significantly differently expressed between the two groups. " -tissue_expression_ns hsa-mir-148a Breast Neoplasms 22976804 "By means of RT-qPCR, we further investigated miRNA expression in more IMPC (n?=?22) and IDC-NSTs (n?=?24) FFPE samples and found let-7b, miR-30c, miR-148a, miR-181a, miR-181a*, and miR-181b were significantly differently expressed between the two groups. " -tissue_expression_ns hsa-mir-181a Breast Neoplasms 22976804 "By means of RT-qPCR, we further investigated miRNA expression in more IMPC (n?=?22) and IDC-NSTs (n?=?24) FFPE samples and found let-7b, miR-30c, miR-148a, miR-181a, miR-181a*, and miR-181b were significantly differently expressed between the two groups. " -tissue_expression_ns hsa-mir-181b Breast Neoplasms 22976804 "By means of RT-qPCR, we further investigated miRNA expression in more IMPC (n?=?22) and IDC-NSTs (n?=?24) FFPE samples and found let-7b, miR-30c, miR-148a, miR-181a, miR-181a*, and miR-181b were significantly differently expressed between the two groups. " -tissue_expression_ns hsa-mir-30c Breast Neoplasms 22976804 "By means of RT-qPCR, we further investigated miRNA expression in more IMPC (n?=?22) and IDC-NSTs (n?=?24) FFPE samples and found let-7b, miR-30c, miR-148a, miR-181a, miR-181a*, and miR-181b were significantly differently expressed between the two groups. " -tissue_expression_ns hsa-let-7a "Carcinoma, Lung, Non-Small-Cell" 23043708 "The relative expressions of 11 miRNAs in sputum (miR-21, miR-145,miR-155, miR-205, miR-210, miR-92, miR-17-5p, miR-143, miR-182, miR-372, and let-7a) in addition to U6 were retrospectively assessed in four NSCLC-positive and four negative controls." -tissue_expression_ns hsa-mir-143 "Carcinoma, Lung, Non-Small-Cell" 23043708 "The relative expressions of 11 miRNAs in sputum (miR-21, miR-145,miR-155, miR-205, miR-210, miR-92, miR-17-5p, miR-143, miR-182, miR-372, and let-7a) in addition to U6 were retrospectively assessed in four NSCLC-positive and four negative controls." -tissue_expression_ns hsa-mir-145 "Carcinoma, Lung, Non-Small-Cell" 23043708 "The relative expressions of 11 miRNAs in sputum (miR-21, miR-145,miR-155, miR-205, miR-210, miR-92, miR-17-5p, miR-143, miR-182, miR-372, and let-7a) in addition to U6 were retrospectively assessed in four NSCLC-positive and four negative controls." -tissue_expression_ns hsa-mir-155 "Carcinoma, Lung, Non-Small-Cell" 23043708 "The relative expressions of 11 miRNAs in sputum (miR-21, miR-145,miR-155, miR-205, miR-210, miR-92, miR-17-5p, miR-143, miR-182, miR-372, and let-7a) in addition to U6 were retrospectively assessed in four NSCLC-positive and four negative controls." -tissue_expression_ns hsa-mir-17 "Carcinoma, Lung, Non-Small-Cell" 23043708 "The relative expressions of 11 miRNAs in sputum (miR-21, miR-145,miR-155, miR-205, miR-210, miR-92, miR-17-5p, miR-143, miR-182, miR-372, and let-7a) in addition to U6 were retrospectively assessed in four NSCLC-positive and four negative controls." -tissue_expression_ns hsa-mir-182 "Carcinoma, Lung, Non-Small-Cell" 23043708 "The relative expressions of 11 miRNAs in sputum (miR-21, miR-145,miR-155, miR-205, miR-210, miR-92, miR-17-5p, miR-143, miR-182, miR-372, and let-7a) in addition to U6 were retrospectively assessed in four NSCLC-positive and four negative controls." -tissue_expression_ns hsa-mir-205 "Carcinoma, Lung, Non-Small-Cell" 23043708 "The relative expressions of 11 miRNAs in sputum (miR-21, miR-145,miR-155, miR-205, miR-210, miR-92, miR-17-5p, miR-143, miR-182, miR-372, and let-7a) in addition to U6 were retrospectively assessed in four NSCLC-positive and four negative controls." -tissue_expression_ns hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 23043708 "The relative expressions of 11 miRNAs in sputum (miR-21, miR-145,miR-155, miR-205, miR-210, miR-92, miR-17-5p, miR-143, miR-182, miR-372, and let-7a) in addition to U6 were retrospectively assessed in four NSCLC-positive and four negative controls." -tissue_expression_ns hsa-mir-210 "Carcinoma, Lung, Non-Small-Cell" 23043708 "The relative expressions of 11 miRNAs in sputum (miR-21, miR-145,miR-155, miR-205, miR-210, miR-92, miR-17-5p, miR-143, miR-182, miR-372, and let-7a) in addition to U6 were retrospectively assessed in four NSCLC-positive and four negative controls." -tissue_expression_ns hsa-mir-372 "Carcinoma, Lung, Non-Small-Cell" 23043708 "The relative expressions of 11 miRNAs in sputum (miR-21, miR-145,miR-155, miR-205, miR-210, miR-92, miR-17-5p, miR-143, miR-182, miR-372, and let-7a) in addition to U6 were retrospectively assessed in four NSCLC-positive and four negative controls." -tissue_expression_ns hsa-mir-92 "Carcinoma, Lung, Non-Small-Cell" 23043708 "The relative expressions of 11 miRNAs in sputum (miR-21, miR-145,miR-155, miR-205, miR-210, miR-92, miR-17-5p, miR-143, miR-182, miR-372, and let-7a) in addition to U6 were retrospectively assessed in four NSCLC-positive and four negative controls." -tissue_expression_ns hsa-mir-183 "Carcinoma, Thyroid, Medullary" 23072640 "This further validates previously reported miRNA profile analyses and reiterates the potential significance of miR-9*, -183 and -375 in the pathophysiology of MTC." -tissue_expression_ns hsa-mir-375 "Carcinoma, Thyroid, Medullary" 23072640 "This further validates previously reported miRNA profile analyses and reiterates the potential significance of miR-9*, -183 and -375 in the pathophysiology of MTC." -tissue_expression_ns hsa-mir-9 "Carcinoma, Thyroid, Medullary" 23072640 "This further validates previously reported miRNA profile analyses and reiterates the potential significance of miR-9*, -183 and -375 in the pathophysiology of MTC." -tissue_expression_ns hsa-mir-200a "Carcinoma, Renal Cell" 23074016 The entire miR-200 seed family is strongly deregulated in clear cell renal cell cancer compared to the proximal tubular epithelial cells of the kidney -tissue_expression_ns hsa-mir-200b "Carcinoma, Renal Cell" 23074016 The entire miR-200 seed family is strongly deregulated in clear cell renal cell cancer compared to the proximal tubular epithelial cells of the kidney -tissue_expression_ns hsa-mir-200c "Carcinoma, Renal Cell" 23074016 The entire miR-200 seed family is strongly deregulated in clear cell renal cell cancer compared to the proximal tubular epithelial cells of the kidney -tissue_expression_ns hsa-mir-196a "Squamous Cell Carcinoma, Lung" 23074073 "Validation of selected microRNAs by in situ hybridization demonstrated strong expression of hsa-miR-196a in the inner tumor; moderate expression of hsa-miR-224 in the inner tumor and tumor front, and strong expression of hsa-miR-650 in the adjacent lung tissue." -tissue_expression_ns hsa-mir-224 "Squamous Cell Carcinoma, Lung" 23074073 "Validation of selected microRNAs by in situ hybridization demonstrated strong expression of hsa-miR-196a in the inner tumor; moderate expression of hsa-miR-224 in the inner tumor and tumor front, and strong expression of hsa-miR-650 in the adjacent lung tissue." -tissue_expression_ns hsa-mir-650 "Squamous Cell Carcinoma, Lung" 23074073 "Validation of selected microRNAs by in situ hybridization demonstrated strong expression of hsa-miR-196a in the inner tumor; moderate expression of hsa-miR-224 in the inner tumor and tumor front, and strong expression of hsa-miR-650 in the adjacent lung tissue." -tissue_expression_ns hsa-mir-16 Preeclampsia 23083510 "Together, these data suggest that the alteration of miR-16 expression in decidua-derived mesenchymal stem cells may be involved in the development of pre-eclampsia." -tissue_expression_ns hsa-mir-143 Esophageal Neoplasms 23092342 "There are several microRNAs that have been consistently reported to be differentially expressed in esophageal squamous cell carcinoma vs. normal squamous tissue, with prognostic associations for miR-21 (invasion, positive nodes, decreased survival), miR-143 (disease recurrence, invasion depth), and miR-375 (inversely correlated with advanced stage, distant metastasis, poor overall survival, and disease-free survival)." -tissue_expression_ns hsa-mir-21 Esophageal Neoplasms 23092342 "There are several microRNAs that have been consistently reported to be differentially expressed in esophageal squamous cell carcinoma vs. normal squamous tissue, with prognostic associations for miR-21 (invasion, positive nodes, decreased survival), miR-143 (disease recurrence, invasion depth), and miR-375 (inversely correlated with advanced stage, distant metastasis, poor overall survival, and disease-free survival)." -tissue_expression_ns hsa-mir-375 Esophageal Neoplasms 23092342 "There are several microRNAs that have been consistently reported to be differentially expressed in esophageal squamous cell carcinoma vs. normal squamous tissue, with prognostic associations for miR-21 (invasion, positive nodes, decreased survival), miR-143 (disease recurrence, invasion depth), and miR-375 (inversely correlated with advanced stage, distant metastasis, poor overall survival, and disease-free survival)." -tissue_expression_ns hsa-mir-210 "Carcinoma, Renal Cell" 23150176 MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma -tissue_expression_ns hsa-mir-155 Breast Neoplasms 23162645 miR-155 and miR-31 are differentially expressed in breast cancer patients and are correlated with the estrogen receptor and progesterone receptor status -tissue_expression_ns hsa-mir-31 Breast Neoplasms 23162645 miR-155 and miR-31 are differentially expressed in breast cancer patients and are correlated with the estrogen receptor and progesterone receptor status -tissue_expression_ns hsa-mir-146b "Squamous Cell Carcinoma, Esophageal" 23175214 "The expression levels of miR-21 (p = 0.027), miR-181b (p = 0.002) and miR-146b (p = 0.021) in tumor tissue and miR-21 (p = 0.003) in noncancerous tissue were associated with overall survival of patients. " -tissue_expression_ns hsa-mir-181b "Squamous Cell Carcinoma, Esophageal" 23175214 "The expression levels of miR-21 (p = 0.027), miR-181b (p = 0.002) and miR-146b (p = 0.021) in tumor tissue and miR-21 (p = 0.003) in noncancerous tissue were associated with overall survival of patients. " -tissue_expression_ns hsa-mir-21 "Squamous Cell Carcinoma, Esophageal" 23175214 "The expression levels of miR-21 (p = 0.027), miR-181b (p = 0.002) and miR-146b (p = 0.021) in tumor tissue and miR-21 (p = 0.003) in noncancerous tissue were associated with overall survival of patients. " -tissue_expression_ns hsa-mir-182 Prostate Neoplasms 23184537 Expression of MicroRNAs associated with Gleason grading system in prostate cancer: miR-182-5p is a useful marker for high grade prostate cancer -tissue_expression_ns hsa-mir-24-1 "Carcinoma, Hepatocellular" 23229173 Human hepatocellular carcinoma cell-specific miRNAs reveal the differential expression of miR-24 and miR-27a in cirrhotic/non-cirrhotic HCC -tissue_expression_ns hsa-mir-24-2 "Carcinoma, Hepatocellular" 23229173 Human hepatocellular carcinoma cell-specific miRNAs reveal the differential expression of miR-24 and miR-27a in cirrhotic/non-cirrhotic HCC -tissue_expression_ns hsa-mir-27a "Carcinoma, Hepatocellular" 23229173 Human hepatocellular carcinoma cell-specific miRNAs reveal the differential expression of miR-24 and miR-27a in cirrhotic/non-cirrhotic HCC -tissue_expression_ns hsa-mir-21 Laryngeal Neoplasms 23259291 Expression of mir-21 and mir-375 in laryngeal squamous cell carcinoma -tissue_expression_ns hsa-mir-375 Laryngeal Neoplasms 23259291 Expression of mir-21 and mir-375 in laryngeal squamous cell carcinoma -tissue_expression_ns hsa-mir-124 Mesial Temporal Lobe Epilepsy 23315173 "Expression patterns of miR-124, miR-134, miR-132, and miR-21 in an immature rat model and children with mesial temporal lobe epilepsy." -tissue_expression_ns hsa-mir-132 Mesial Temporal Lobe Epilepsy 23315173 "Expression patterns of miR-124, miR-134, miR-132, and miR-21 in an immature rat model and children with mesial temporal lobe epilepsy." -tissue_expression_ns hsa-mir-134 Mesial Temporal Lobe Epilepsy 23315173 "Expression patterns of miR-124, miR-134, miR-132, and miR-21 in an immature rat model and children with mesial temporal lobe epilepsy." -tissue_expression_ns hsa-mir-21 Mesial Temporal Lobe Epilepsy 23315173 "Expression patterns of miR-124, miR-134, miR-132, and miR-21 in an immature rat model and children with mesial temporal lobe epilepsy." -tissue_expression_ns hsa-mir-150 Myeloproliferative Neoplasms 23343777 "An aberrant expression of miRNAs 10a and 150 could be demonstrated for essential thrombocythemia and PMF as well as for polycythemia vera and PMF, respectively. The expression of miR-150 could further be shown to correlate with both JAK2 allele burden and peripheral blood counts." -tissue_expression_ns hsa-mir-31 Immune System Disease [unspecific] 23352895 "Bantam, miR-276*, miR-10, miR-31 and miR-184 were detected as five most abundant miRNAs in both libraries and 96 miRNAs were identified that were differentially expressed after parasitization." -tissue_expression_ns hsa-let-7a Lung Neoplasms 23365639 "Specifically, let-7 and miR-9 are deregulated in both lung cancers and other solid malignancies." -tissue_expression_ns hsa-mir-9 Lung Neoplasms 23365639 "Specifically, let-7 and miR-9 are deregulated in both lung cancers and other solid malignancies." -tissue_expression_ns hsa-let-7a Melanoma 23377970 "Detailed studies of different groups thereafter identified miRNAs with differential expression in benign melanocytes compared with melanoma cell lines or in benign melanocytic lesions compared with melanomas. Among these were let-7a and b, miR-23a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR214, and miR-221 and 222." -tissue_expression_ns hsa-let-7b Melanoma 23377970 "Detailed studies of different groups thereafter identified miRNAs with differential expression in benign melanocytes compared with melanoma cell lines or in benign melanocytic lesions compared with melanomas. Among these were let-7a and b, miR-23a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR214, and miR-221 and 222." -tissue_expression_ns hsa-mir-148 Melanoma 23377970 "Detailed studies of different groups thereafter identified miRNAs with differential expression in benign melanocytes compared with melanoma cell lines or in benign melanocytic lesions compared with melanomas. Among these were let-7a and b, miR-23a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR214, and miR-221 and 222." -tissue_expression_ns hsa-mir-155 Melanoma 23377970 "Detailed studies of different groups thereafter identified miRNAs with differential expression in benign melanocytes compared with melanoma cell lines or in benign melanocytic lesions compared with melanomas. Among these were let-7a and b, miR-23a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR214, and miR-221 and 222." -tissue_expression_ns hsa-mir-182 Melanoma 23377970 "Detailed studies of different groups thereafter identified miRNAs with differential expression in benign melanocytes compared with melanoma cell lines or in benign melanocytic lesions compared with melanomas. Among these were let-7a and b, miR-23a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR214, and miR-221 and 222." -tissue_expression_ns hsa-mir-200c Melanoma 23377970 "Detailed studies of different groups thereafter identified miRNAs with differential expression in benign melanocytes compared with melanoma cell lines or in benign melanocytic lesions compared with melanomas. Among these were let-7a and b, miR-23a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR214, and miR-221 and 222." -tissue_expression_ns hsa-mir-211 Melanoma 23377970 "Detailed studies of different groups thereafter identified miRNAs with differential expression in benign melanocytes compared with melanoma cell lines or in benign melanocytic lesions compared with melanomas. Among these were let-7a and b, miR-23a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR214, and miR-221 and 222." -tissue_expression_ns hsa-mir-214 Melanoma 23377970 "Detailed studies of different groups thereafter identified miRNAs with differential expression in benign melanocytes compared with melanoma cell lines or in benign melanocytic lesions compared with melanomas. Among these were let-7a and b, miR-23a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR214, and miR-221 and 222." -tissue_expression_ns hsa-mir-221 Melanoma 23377970 "Detailed studies of different groups thereafter identified miRNAs with differential expression in benign melanocytes compared with melanoma cell lines or in benign melanocytic lesions compared with melanomas. Among these were let-7a and b, miR-23a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR214, and miR-221 and 222." -tissue_expression_ns hsa-mir-222 Melanoma 23377970 "Detailed studies of different groups thereafter identified miRNAs with differential expression in benign melanocytes compared with melanoma cell lines or in benign melanocytic lesions compared with melanomas. Among these were let-7a and b, miR-23a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR214, and miR-221 and 222." -tissue_expression_ns hsa-mir-23a Melanoma 23377970 "Detailed studies of different groups thereafter identified miRNAs with differential expression in benign melanocytes compared with melanoma cell lines or in benign melanocytic lesions compared with melanomas. Among these were let-7a and b, miR-23a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR214, and miR-221 and 222." -tissue_expression_ns hsa-mir-23b Melanoma 23377970 "Detailed studies of different groups thereafter identified miRNAs with differential expression in benign melanocytes compared with melanoma cell lines or in benign melanocytic lesions compared with melanomas. Among these were let-7a and b, miR-23a and b, miR-148, miR-155, miR-182, miR-200c, miR-211, miR214, and miR-221 and 222." -tissue_expression_ns hsa-mir-103 "Diabetes Mellitus, Type 2" 23389544 "The deregulation of miRNAs miR-143 (ref. 4), miR-181 (ref. 5), and miR-103 and miR-107 (ref. 6) alters hepatic insulin sensitivity." -tissue_expression_ns hsa-mir-107 "Diabetes Mellitus, Type 2" 23389544 "The deregulation of miRNAs miR-143 (ref. 4), miR-181 (ref. 5), and miR-103 and miR-107 (ref. 6) alters hepatic insulin sensitivity." -tissue_expression_ns hsa-mir-143 "Diabetes Mellitus, Type 2" 23389544 "The deregulation of miRNAs miR-143 (ref. 4), miR-181 (ref. 5), and miR-103 and miR-107 (ref. 6) alters hepatic insulin sensitivity." -tissue_expression_ns hsa-mir-181 "Diabetes Mellitus, Type 2" 23389544 "The deregulation of miRNAs miR-143 (ref. 4), miR-181 (ref. 5), and miR-103 and miR-107 (ref. 6) alters hepatic insulin sensitivity." -tissue_expression_ns hsa-mir-181-2 "Carcinoma, Thyroid, Papillary" 23427895 "Fourteen miRNAs were deregulated in FVPTC with a fold change of more than five (up/down), including miRNAs known to be upregulated in PTC (miR-146b-3p, -146-5p, -221, -222 and miR-222-5p) and novel miRNAs (miR-375, -551b, 181-2-3p, 99b-3p)." -tissue_expression_ns hsa-mir-375 "Carcinoma, Thyroid, Papillary" 23427895 "Fourteen miRNAs were deregulated in FVPTC with a fold change of more than five (up/down), including miRNAs known to be upregulated in PTC (miR-146b-3p, -146-5p, -221, -222 and miR-222-5p) and novel miRNAs (miR-375, -551b, 181-2-3p, 99b-3p)." -tissue_expression_ns hsa-mir-551b "Carcinoma, Thyroid, Papillary" 23427895 "Fourteen miRNAs were deregulated in FVPTC with a fold change of more than five (up/down), including miRNAs known to be upregulated in PTC (miR-146b-3p, -146-5p, -221, -222 and miR-222-5p) and novel miRNAs (miR-375, -551b, 181-2-3p, 99b-3p)." -tissue_expression_ns hsa-mir-99b "Carcinoma, Thyroid, Papillary" 23427895 "Fourteen miRNAs were deregulated in FVPTC with a fold change of more than five (up/down), including miRNAs known to be upregulated in PTC (miR-146b-3p, -146-5p, -221, -222 and miR-222-5p) and novel miRNAs (miR-375, -551b, 181-2-3p, 99b-3p)." -tissue_expression_ns hsa-mir-146b Gastrointestinal Neoplasms 23456798 "The deregulation of miR-146b-5p, miR-375, miR-148a, miR-31, and miR-451 was associated significantly with gastric adenocarcinomas." -tissue_expression_ns hsa-mir-148a Gastrointestinal Neoplasms 23456798 "The deregulation of miR-146b-5p, miR-375, miR-148a, miR-31, and miR-451 was associated significantly with gastric adenocarcinomas." -tissue_expression_ns hsa-mir-31 Gastrointestinal Neoplasms 23456798 "The deregulation of miR-146b-5p, miR-375, miR-148a, miR-31, and miR-451 was associated significantly with gastric adenocarcinomas." -tissue_expression_ns hsa-mir-375 Gastrointestinal Neoplasms 23456798 "The deregulation of miR-146b-5p, miR-375, miR-148a, miR-31, and miR-451 was associated significantly with gastric adenocarcinomas." -tissue_expression_ns hsa-mir-451 Gastrointestinal Neoplasms 23456798 "The deregulation of miR-146b-5p, miR-375, miR-148a, miR-31, and miR-451 was associated significantly with gastric adenocarcinomas." -tissue_expression_ns hsa-mir-126 Cholangiocarcinoma 23458262 Concomitant dysregulation of microRNAs miR-151-3p and miR-126 correlates with improved survival in resected cholangiocarcinoma -tissue_expression_ns hsa-mir-151 Cholangiocarcinoma 23458262 Concomitant dysregulation of microRNAs miR-151-3p and miR-126 correlates with improved survival in resected cholangiocarcinoma -tissue_expression_ns hsa-mir-302b Ovarian Neoplasms 23484053 hsa-miR-302b expression was significantly associated with time to relapse or overall survival in two data sets of platinum-treated ovarian cancer patients. -tissue_expression_ns hsa-mir-1303 "Carcinoma, Breast" 23526361 "Among these, a 5-miRNA signature comprising miR-421, miR-486, miR-503, miR-720 and miR-1303 was shown to be predictive for IBC phenotype with an overall accuracy of 89%. " -tissue_expression_ns hsa-mir-421 "Carcinoma, Breast" 23526361 "Among these, a 5-miRNA signature comprising miR-421, miR-486, miR-503, miR-720 and miR-1303 was shown to be predictive for IBC phenotype with an overall accuracy of 89%. " -tissue_expression_ns hsa-mir-486 "Carcinoma, Breast" 23526361 "Among these, a 5-miRNA signature comprising miR-421, miR-486, miR-503, miR-720 and miR-1303 was shown to be predictive for IBC phenotype with an overall accuracy of 89%. " -tissue_expression_ns hsa-mir-503 "Carcinoma, Breast" 23526361 "Among these, a 5-miRNA signature comprising miR-421, miR-486, miR-503, miR-720 and miR-1303 was shown to be predictive for IBC phenotype with an overall accuracy of 89%. " -tissue_expression_ns hsa-mir-720 "Carcinoma, Breast" 23526361 "Among these, a 5-miRNA signature comprising miR-421, miR-486, miR-503, miR-720 and miR-1303 was shown to be predictive for IBC phenotype with an overall accuracy of 89%. " -tissue_expression_ns hsa-mir-21 Viral Myocarditis 23544605 Myocardial miR-21 expression was negatively related to viral myocarditis severity. -tissue_expression_ns hsa-mir-135b Colorectal Carcinoma 23568010 "our results are contradictory to previous studies performed on the CRC patients from Chinese population, providing an evidence against usage of serum miR-17-3p, miR-29a, miR-92a and miR-135b as new biomarkers for early detection of CRC" -tissue_expression_ns hsa-mir-17 Colorectal Carcinoma 23568010 "our results are contradictory to previous studies performed on the CRC patients from Chinese population, providing an evidence against usage of serum miR-17-3p, miR-29a, miR-92a and miR-135b as new biomarkers for early detection of CRC" -tissue_expression_ns hsa-mir-29a Colorectal Carcinoma 23568010 "our results are contradictory to previous studies performed on the CRC patients from Chinese population, providing an evidence against usage of serum miR-17-3p, miR-29a, miR-92a and miR-135b as new biomarkers for early detection of CRC" -tissue_expression_ns hsa-mir-92a Colorectal Carcinoma 23568010 "our results are contradictory to previous studies performed on the CRC patients from Chinese population, providing an evidence against usage of serum miR-17-3p, miR-29a, miR-92a and miR-135b as new biomarkers for early detection of CRC" -tissue_expression_ns hsa-mir-221 Ovarian Neoplasms 23569131 Prognostic significance of serum microRNA-221 expression in human epithelial ovarian cancer -tissue_expression_ns hsa-mir-192 "Adenocarcinoma, Pancreatic Ductal" 23612862 miRNA expression profiling of human PDACs and adjacent normal pancreatic tissues identified 16 upregulated miRNAs including miR-192 and 8 downregulated miRNAs. -tissue_expression_ns hsa-mir-100 Prostate Neoplasms 23621234 "In conclusion, expression changes in miRNAs of miR-146a, miR-100, miR-425, miR-193a-3p and, miR-106b in metformin-treated cells may be important." -tissue_expression_ns hsa-mir-106b Prostate Neoplasms 23621234 "In conclusion, expression changes in miRNAs of miR-146a, miR-100, miR-425, miR-193a-3p and, miR-106b in metformin-treated cells may be important." -tissue_expression_ns hsa-mir-146a Prostate Neoplasms 23621234 "In conclusion, expression changes in miRNAs of miR-146a, miR-100, miR-425, miR-193a-3p and, miR-106b in metformin-treated cells may be important." -tissue_expression_ns hsa-mir-193a Prostate Neoplasms 23621234 "In conclusion, expression changes in miRNAs of miR-146a, miR-100, miR-425, miR-193a-3p and, miR-106b in metformin-treated cells may be important." -tissue_expression_ns hsa-mir-425 Prostate Neoplasms 23621234 "In conclusion, expression changes in miRNAs of miR-146a, miR-100, miR-425, miR-193a-3p and, miR-106b in metformin-treated cells may be important." -tissue_expression_ns hsa-mir-141 "Carcinoma, Renal Cell" 23635949 "Our recent studies of microRNA (miRNA) expression signatures demonstrated that the epithelial-mesenchymal transition (EMT)-related microRNA-200 family (miR-200s: miR-200a/b/c, miR-141 and miR-429) were significantly downregulated in renal cell carcinoma (RCC) and putative tumor-suppressive miRNAs in RCC." -tissue_expression_ns hsa-mir-200a "Carcinoma, Renal Cell" 23635949 "Our recent studies of microRNA (miRNA) expression signatures demonstrated that the epithelial-mesenchymal transition (EMT)-related microRNA-200 family (miR-200s: miR-200a/b/c, miR-141 and miR-429) were significantly downregulated in renal cell carcinoma (RCC) and putative tumor-suppressive miRNAs in RCC." -tissue_expression_ns hsa-mir-200b "Carcinoma, Renal Cell" 23635949 "Our recent studies of microRNA (miRNA) expression signatures demonstrated that the epithelial-mesenchymal transition (EMT)-related microRNA-200 family (miR-200s: miR-200a/b/c, miR-141 and miR-429) were significantly downregulated in renal cell carcinoma (RCC) and putative tumor-suppressive miRNAs in RCC." -tissue_expression_ns hsa-mir-200c "Carcinoma, Renal Cell" 23635949 "Our recent studies of microRNA (miRNA) expression signatures demonstrated that the epithelial-mesenchymal transition (EMT)-related microRNA-200 family (miR-200s: miR-200a/b/c, miR-141 and miR-429) were significantly downregulated in renal cell carcinoma (RCC) and putative tumor-suppressive miRNAs in RCC." -tissue_expression_ns hsa-mir-429 "Carcinoma, Renal Cell" 23635949 "Our recent studies of microRNA (miRNA) expression signatures demonstrated that the epithelial-mesenchymal transition (EMT)-related microRNA-200 family (miR-200s: miR-200a/b/c, miR-141 and miR-429) were significantly downregulated in renal cell carcinoma (RCC) and putative tumor-suppressive miRNAs in RCC." -tissue_expression_ns hsa-mir-1 "Carcinoma, Skin" 23646287 "Differential expression of miR-1, a putative tumor suppressing microRNA, in cancer resistant and cancer susceptible mice." -tissue_expression_ns hsa-mir-106b Colorectal Carcinoma 23690963 "Nine of the twelve miRNAs (miR-18a, -20a, -21, -29a, -92a, -106b, -133a, -143, -145) were found to be differentially expressed in CRC patients and controls in the validation samples." -tissue_expression_ns hsa-mir-133a Colorectal Carcinoma 23690963 "Nine of the twelve miRNAs (miR-18a, -20a, -21, -29a, -92a, -106b, -133a, -143, -145) were found to be differentially expressed in CRC patients and controls in the validation samples." -tissue_expression_ns hsa-mir-143 Colorectal Carcinoma 23690963 "Nine of the twelve miRNAs (miR-18a, -20a, -21, -29a, -92a, -106b, -133a, -143, -145) were found to be differentially expressed in CRC patients and controls in the validation samples." -tissue_expression_ns hsa-mir-145 Colorectal Carcinoma 23690963 "Nine of the twelve miRNAs (miR-18a, -20a, -21, -29a, -92a, -106b, -133a, -143, -145) were found to be differentially expressed in CRC patients and controls in the validation samples." -tissue_expression_ns hsa-mir-18a Colorectal Carcinoma 23690963 "Nine of the twelve miRNAs (miR-18a, -20a, -21, -29a, -92a, -106b, -133a, -143, -145) were found to be differentially expressed in CRC patients and controls in the validation samples." -tissue_expression_ns hsa-mir-20a Colorectal Carcinoma 23690963 "Nine of the twelve miRNAs (miR-18a, -20a, -21, -29a, -92a, -106b, -133a, -143, -145) were found to be differentially expressed in CRC patients and controls in the validation samples." -tissue_expression_ns hsa-mir-21 Colorectal Carcinoma 23690963 "Nine of the twelve miRNAs (miR-18a, -20a, -21, -29a, -92a, -106b, -133a, -143, -145) were found to be differentially expressed in CRC patients and controls in the validation samples." -tissue_expression_ns hsa-mir-29a Colorectal Carcinoma 23690963 "Nine of the twelve miRNAs (miR-18a, -20a, -21, -29a, -92a, -106b, -133a, -143, -145) were found to be differentially expressed in CRC patients and controls in the validation samples." -tissue_expression_ns hsa-mir-92a Colorectal Carcinoma 23690963 "Nine of the twelve miRNAs (miR-18a, -20a, -21, -29a, -92a, -106b, -133a, -143, -145) were found to be differentially expressed in CRC patients and controls in the validation samples." -tissue_expression_ns hsa-mir-147b Neuroblastoma 23724168 "Numerous miRNAs were detected by microarrays to be regulated by the combined lithium and valproic acid treatment, and the following candidates were confirmed using real-time PCR: miR-34a, miR-147b, miR-182,miR-222, miR-495, and miR-690. " -tissue_expression_ns hsa-mir-182 Neuroblastoma 23724168 "Numerous miRNAs were detected by microarrays to be regulated by the combined lithium and valproic acid treatment, and the following candidates were confirmed using real-time PCR: miR-34a, miR-147b, miR-182,miR-222, miR-495, and miR-690. " -tissue_expression_ns hsa-mir-222 Neuroblastoma 23724168 "Numerous miRNAs were detected by microarrays to be regulated by the combined lithium and valproic acid treatment, and the following candidates were confirmed using real-time PCR: miR-34a, miR-147b, miR-182,miR-222, miR-495, and miR-690. " -tissue_expression_ns hsa-mir-34a Neuroblastoma 23724168 "Numerous miRNAs were detected by microarrays to be regulated by the combined lithium and valproic acid treatment, and the following candidates were confirmed using real-time PCR: miR-34a, miR-147b, miR-182,miR-222, miR-495, and miR-690. " -tissue_expression_ns hsa-mir-496 Neuroblastoma 23724168 "Numerous miRNAs were detected by microarrays to be regulated by the combined lithium and valproic acid treatment, and the following candidates were confirmed using real-time PCR: miR-34a, miR-147b, miR-182,miR-222, miR-495, and miR-690. " -tissue_expression_ns hsa-mir-690 Neuroblastoma 23724168 "Numerous miRNAs were detected by microarrays to be regulated by the combined lithium and valproic acid treatment, and the following candidates were confirmed using real-time PCR: miR-34a, miR-147b, miR-182,miR-222, miR-495, and miR-690. " -tissue_expression_ns hsa-mir-146a Urinary Bladder Cancer 23749909 altered expression -tissue_expression_ns hsa-mir-155 Urinary Bladder Cancer 23749909 altered expression -tissue_expression_ns hsa-mir-196a-1 Urinary Bladder Cancer 23749909 altered expression -tissue_expression_ns hsa-mir-196a-2 Urinary Bladder Cancer 23749909 altered expression -tissue_expression_ns hsa-mir-203 Urinary Bladder Cancer 23749909 altered expression -tissue_expression_ns hsa-mir-21 Urinary Bladder Cancer 23749909 altered expression -tissue_expression_ns hsa-mir-221 Urinary Bladder Cancer 23749909 altered expression -tissue_expression_ns hsa-mir-27a Urinary Bladder Cancer 23749909 altered expression -tissue_expression_ns hsa-mir-34a Urinary Bladder Cancer 23749909 altered expression -tissue_expression_ns hsa-mir-205 "Carcinoma, Lung, Non-Small-Cell" 23759980 Identification of microRNAs differentially expressed between lung squamous cell carcinoma and lung adenocarcinoma. -tissue_expression_ns hsa-mir-182 Neoplasms [unspecific] 23791657 Meta-analysis of microRNA-183 family expression in human cancer studies comparing cancer tissues with noncancerous tissues. -tissue_expression_ns hsa-mir-183 Neoplasms [unspecific] 23791657 Meta-analysis of microRNA-183 family expression in human cancer studies comparing cancer tissues with noncancerous tissues. -tissue_expression_ns hsa-mir-96 Neoplasms [unspecific] 23791657 Meta-analysis of microRNA-183 family expression in human cancer studies comparing cancer tissues with noncancerous tissues. -tissue_expression_ns hsa-mir-1 Breast Neoplasms 23797906 "The clinical use of miRNA signatures as a noninvasive diagnostic strategy is promising, but should be further validated for different subtypes of breast cancers." -tissue_expression_ns hsa-mir-133a Breast Neoplasms 23797906 "The clinical use of miRNA signatures as a noninvasive diagnostic strategy is promising, but should be further validated for different subtypes of breast cancers." -tissue_expression_ns hsa-mir-133b Breast Neoplasms 23797906 "The clinical use of miRNA signatures as a noninvasive diagnostic strategy is promising, but should be further validated for different subtypes of breast cancers." -tissue_expression_ns hsa-mir-92a Breast Neoplasms 23797906 "The clinical use of miRNA signatures as a noninvasive diagnostic strategy is promising, but should be further validated for different subtypes of breast cancers." -tissue_expression_ns hsa-let-7c "Carcinoma, Renal Cell" 23799849 "MicroRNAs are able to accurately classify RCC samples. Deregulated miRNAs might contribute to the high chemotherapy resistance of RCC. Furthermore, our results indicate that pRCC type 2 tumours could be dependent on oncogenic MYC signalling." -tissue_expression_ns hsa-mir-145 "Carcinoma, Renal Cell" 23799849 "MicroRNAs are able to accurately classify RCC samples. Deregulated miRNAs might contribute to the high chemotherapy resistance of RCC. Furthermore, our results indicate that pRCC type 2 tumours could be dependent on oncogenic MYC signalling." -tissue_expression_ns hsa-mir-200c "Carcinoma, Renal Cell" 23799849 "MicroRNAs are able to accurately classify RCC samples. Deregulated miRNAs might contribute to the high chemotherapy resistance of RCC. Furthermore, our results indicate that pRCC type 2 tumours could be dependent on oncogenic MYC signalling." -tissue_expression_ns hsa-mir-210 "Carcinoma, Renal Cell" 23799849 "MicroRNAs are able to accurately classify RCC samples. Deregulated miRNAs might contribute to the high chemotherapy resistance of RCC. Furthermore, our results indicate that pRCC type 2 tumours could be dependent on oncogenic MYC signalling." -tissue_expression_ns hsa-mir-502 "Carcinoma, Renal Cell" 23799849 "MicroRNAs are able to accurately classify RCC samples. Deregulated miRNAs might contribute to the high chemotherapy resistance of RCC. Furthermore, our results indicate that pRCC type 2 tumours could be dependent on oncogenic MYC signalling." -tissue_expression_ns hsa-mir-135b "Lymphoma, Large B-Cell" 23801630 MicroRNA expression profiling identifies molecular signatures associated with anaplastic large cell lymphoma. -tissue_expression_ns hsa-mir-146a "Lymphoma, Large B-Cell" 23801630 MicroRNA expression profiling identifies molecular signatures associated with anaplastic large cell lymphoma. -tissue_expression_ns hsa-mir-155 "Lymphoma, Large B-Cell" 23801630 MicroRNA expression profiling identifies molecular signatures associated with anaplastic large cell lymphoma. -tissue_expression_ns hsa-mir-512 "Lymphoma, Large B-Cell" 23801630 MicroRNA expression profiling identifies molecular signatures associated with anaplastic large cell lymphoma. -tissue_expression_ns hsa-mir-708 "Lymphoma, Large B-Cell" 23801630 MicroRNA expression profiling identifies molecular signatures associated with anaplastic large cell lymphoma. -tissue_expression_ns hsa-mir-886 "Lymphoma, Large B-Cell" 23801630 MicroRNA expression profiling identifies molecular signatures associated with anaplastic large cell lymphoma. -tissue_expression_ns hsa-mir-219 Obesity 23817051 "the miRNA profile is altered in amnion during obesity and hypothesize that this could affect pathways important for placental growth and function, thereby contributing to an increase in the newborn's risk of future metabolic diseases." -tissue_expression_ns hsa-mir-422b Obesity 23817051 "the miRNA profile is altered in amnion during obesity and hypothesize that this could affect pathways important for placental growth and function, thereby contributing to an increase in the newborn's risk of future metabolic diseases." -tissue_expression_ns hsa-mir-523 Obesity 23817051 "the miRNA profile is altered in amnion during obesity and hypothesize that this could affect pathways important for placental growth and function, thereby contributing to an increase in the newborn's risk of future metabolic diseases." -tissue_expression_ns hsa-mir-575 Obesity 23817051 "the miRNA profile is altered in amnion during obesity and hypothesize that this could affect pathways important for placental growth and function, thereby contributing to an increase in the newborn's risk of future metabolic diseases." -tissue_expression_ns hsa-mir-579 Obesity 23817051 "the miRNA profile is altered in amnion during obesity and hypothesize that this could affect pathways important for placental growth and function, thereby contributing to an increase in the newborn's risk of future metabolic diseases." -tissue_expression_ns hsa-mir-618 Obesity 23817051 "the miRNA profile is altered in amnion during obesity and hypothesize that this could affect pathways important for placental growth and function, thereby contributing to an increase in the newborn's risk of future metabolic diseases." -tissue_expression_ns hsa-mir-659 Obesity 23817051 "the miRNA profile is altered in amnion during obesity and hypothesize that this could affect pathways important for placental growth and function, thereby contributing to an increase in the newborn's risk of future metabolic diseases." -tissue_expression_ns hsa-mir-378 Liver Diseases [unspecific] 23818290 Dietary fisetin protects against hepatosteatosis in association with modulation of lipid metabolism genes and miR-378 in mice -tissue_expression_ns hsa-mir-149 Chordoma 23826111 "This study provides an integrated dataset of the miRNA and mRNA profiles in chordomas, and the results demonstrate that not only the MAPK pathway and its related miRNAs but also the Notch pathway may be involved in chordoma development. The occurrence of chordoma may be associated with dysfunctional calcification or ossification of the notochord." -tissue_expression_ns hsa-mir-1908 Chordoma 23826111 "This study provides an integrated dataset of the miRNA and mRNA profiles in chordomas, and the results demonstrate that not only the MAPK pathway and its related miRNAs but also the Notch pathway may be involved in chordoma development. The occurrence of chordoma may be associated with dysfunctional calcification or ossification of the notochord." -tissue_expression_ns hsa-mir-2861 Chordoma 23826111 "This study provides an integrated dataset of the miRNA and mRNA profiles in chordomas, and the results demonstrate that not only the MAPK pathway and its related miRNAs but also the Notch pathway may be involved in chordoma development. The occurrence of chordoma may be associated with dysfunctional calcification or ossification of the notochord." -tissue_expression_ns hsa-mir-3185 Chordoma 23826111 "This study provides an integrated dataset of the miRNA and mRNA profiles in chordomas, and the results demonstrate that not only the MAPK pathway and its related miRNAs but also the Notch pathway may be involved in chordoma development. The occurrence of chordoma may be associated with dysfunctional calcification or ossification of the notochord." -tissue_expression_ns hsa-mir-663a Chordoma 23826111 "This study provides an integrated dataset of the miRNA and mRNA profiles in chordomas, and the results demonstrate that not only the MAPK pathway and its related miRNAs but also the Notch pathway may be involved in chordoma development. The occurrence of chordoma may be associated with dysfunctional calcification or ossification of the notochord." -tissue_expression_ns hsa-mir-1264 Laryngeal Neoplasms 23826416 Gene and microRNA expression reveals sensitivity to paclitaxel in laryngeal cancer cell line. -tissue_expression_ns hsa-mir-1265 Laryngeal Neoplasms 23826416 Gene and microRNA expression reveals sensitivity to paclitaxel in laryngeal cancer cell line. -tissue_expression_ns hsa-mir-1277 Laryngeal Neoplasms 23826416 Gene and microRNA expression reveals sensitivity to paclitaxel in laryngeal cancer cell line. -tissue_expression_ns hsa-mir-1291 Laryngeal Neoplasms 23826416 Gene and microRNA expression reveals sensitivity to paclitaxel in laryngeal cancer cell line. -tissue_expression_ns hsa-mir-130a Laryngeal Neoplasms 23826416 Gene and microRNA expression reveals sensitivity to paclitaxel in laryngeal cancer cell line. -tissue_expression_ns hsa-mir-195 Laryngeal Neoplasms 23826416 Gene and microRNA expression reveals sensitivity to paclitaxel in laryngeal cancer cell line. -tissue_expression_ns hsa-mir-214 Laryngeal Neoplasms 23826416 Gene and microRNA expression reveals sensitivity to paclitaxel in laryngeal cancer cell line. -tissue_expression_ns hsa-mir-27b Laryngeal Neoplasms 23826416 Gene and microRNA expression reveals sensitivity to paclitaxel in laryngeal cancer cell line. -tissue_expression_ns hsa-mir-191 Preeclampsia 23830491 Several miRNAs are found to be dysregulated in placentas of PE patients and they seem to be closely associated with the early pathogenesis of PE. Further study is necessary to develop tools for early detection and management. -tissue_expression_ns hsa-mir-197 Preeclampsia 23830491 Several miRNAs are found to be dysregulated in placentas of PE patients and they seem to be closely associated with the early pathogenesis of PE. Further study is necessary to develop tools for early detection and management. -tissue_expression_ns hsa-mir-198 Preeclampsia 23830491 Several miRNAs are found to be dysregulated in placentas of PE patients and they seem to be closely associated with the early pathogenesis of PE. Further study is necessary to develop tools for early detection and management. -tissue_expression_ns hsa-mir-202 Preeclampsia 23830491 Several miRNAs are found to be dysregulated in placentas of PE patients and they seem to be closely associated with the early pathogenesis of PE. Further study is necessary to develop tools for early detection and management. -tissue_expression_ns hsa-mir-204 Preeclampsia 23830491 Several miRNAs are found to be dysregulated in placentas of PE patients and they seem to be closely associated with the early pathogenesis of PE. Further study is necessary to develop tools for early detection and management. -tissue_expression_ns hsa-mir-25 Preeclampsia 23830491 Several miRNAs are found to be dysregulated in placentas of PE patients and they seem to be closely associated with the early pathogenesis of PE. Further study is necessary to develop tools for early detection and management. -tissue_expression_ns hsa-mir-26a Preeclampsia 23830491 Several miRNAs are found to be dysregulated in placentas of PE patients and they seem to be closely associated with the early pathogenesis of PE. Further study is necessary to develop tools for early detection and management. -tissue_expression_ns hsa-mir-26b Preeclampsia 23830491 Several miRNAs are found to be dysregulated in placentas of PE patients and they seem to be closely associated with the early pathogenesis of PE. Further study is necessary to develop tools for early detection and management. -tissue_expression_ns hsa-mir-296 Preeclampsia 23830491 Several miRNAs are found to be dysregulated in placentas of PE patients and they seem to be closely associated with the early pathogenesis of PE. Further study is necessary to develop tools for early detection and management. -tissue_expression_ns hsa-mir-342 Preeclampsia 23830491 Several miRNAs are found to be dysregulated in placentas of PE patients and they seem to be closely associated with the early pathogenesis of PE. Further study is necessary to develop tools for early detection and management. -tissue_expression_ns hsa-mir-92b Preeclampsia 23830491 Several miRNAs are found to be dysregulated in placentas of PE patients and they seem to be closely associated with the early pathogenesis of PE. Further study is necessary to develop tools for early detection and management. -tissue_expression_ns hsa-mir-95 Preeclampsia 23830491 Several miRNAs are found to be dysregulated in placentas of PE patients and they seem to be closely associated with the early pathogenesis of PE. Further study is necessary to develop tools for early detection and management. -tissue_expression_ns hsa-mir-483 "Carcinoma, Ovarian, Serous" 23836287 MiRNA expression signature for potentially predicting the prognosis of ovarian serous carcinoma. -tissue_expression_ns hsa-mir-508 "Carcinoma, Ovarian, Serous" 23836287 MiRNA expression signature for potentially predicting the prognosis of ovarian serous carcinoma. -tissue_expression_ns hsa-mir-509 "Carcinoma, Ovarian, Serous" 23836287 MiRNA expression signature for potentially predicting the prognosis of ovarian serous carcinoma. -tissue_expression_ns hsa-mir-510 "Carcinoma, Ovarian, Serous" 23836287 MiRNA expression signature for potentially predicting the prognosis of ovarian serous carcinoma. -tissue_expression_ns hsa-mir-206 Vascular Hypertrophy 23842077 miR-206 was depressed in the hypertrophied RV of Hx rats but was increased in growth-retarded SM. -tissue_expression_ns hsa-mir-205 Wounds and Injuries [unspecific] 23861701 "we predicted that topical treatment of shikonin in vivo affects epithelial-mesenchymal transition (EMT) and the expression of related microRNAs, including 200a, 200b, 200c, 141, 205, and 429 microRNAs, in mouse skin tissues." -tissue_expression_ns hsa-mir-29b "Carcinoma, Hepatocellular" 23863670 The combined detection of miRNA-29b and AFP aids the diagnosis of PHC and the prediction of its prognosis. -tissue_expression_ns hsa-mir-155 Lymphoma 23871213 The expression ratio of miR-17-5p and miR-155 correlates with grading in canine splenic lymphoma. -tissue_expression_ns hsa-mir-1246 Pterygium 23872359 miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. -tissue_expression_ns hsa-mir-1308 Pterygium 23872359 miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. -tissue_expression_ns hsa-mir-141 Pterygium 23872359 miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. -tissue_expression_ns hsa-mir-143 Pterygium 23872359 miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. -tissue_expression_ns hsa-mir-18a Pterygium 23872359 miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. -tissue_expression_ns hsa-mir-1972 Pterygium 23872359 miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. -tissue_expression_ns hsa-mir-1973 Pterygium 23872359 miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. -tissue_expression_ns hsa-mir-200a Pterygium 23872359 miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. -tissue_expression_ns hsa-mir-200b Pterygium 23872359 miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. -tissue_expression_ns hsa-mir-210 Pterygium 23872359 miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. -tissue_expression_ns hsa-mir-211 Pterygium 23872359 miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. -tissue_expression_ns hsa-mir-29b Pterygium 23872359 miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. -tissue_expression_ns hsa-mir-31 Pterygium 23872359 miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. -tissue_expression_ns hsa-mir-3172 Pterygium 23872359 miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. -tissue_expression_ns hsa-mir-3175 Pterygium 23872359 miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. -tissue_expression_ns hsa-mir-375 Pterygium 23872359 miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. -tissue_expression_ns hsa-mir-451 Pterygium 23872359 miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. -tissue_expression_ns hsa-mir-486 Pterygium 23872359 miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. -tissue_expression_ns hsa-mir-663b Pterygium 23872359 miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. -tissue_expression_ns hsa-mir-665 Pterygium 23872359 miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. -tissue_expression_ns hsa-mir-675 Pterygium 23872359 miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. -tissue_expression_ns hsa-mir-934 Pterygium 23872359 miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium. -tissue_expression_ns hsa-let-7e "Colitis, Ulcerative" 23885139 "The present study provides the first evidence that miR-20b, miR-98, miR-125b-1*, and let-7e* are deregulated in patients with UC." -tissue_expression_ns hsa-let-7d Asthma 23885321 "Differential expression of miR-1248, miR-26a, Let-7a, and Let-7d were observed in asthmatic patients compared to controls." -tissue_expression_ns hsa-mir-15b Gastric Neoplasms 23907579 The modulation of miR-15b and miR-16 mediated the apoptosis effects of DHA in gastric cancer cells. -tissue_expression_ns hsa-mir-524 Glioblastoma 23924460 The miRNA gene expression profiles correlate with several selected MRI features of patients with GBM. Further analysis of key imaging features of MRI with correlation with miRNA gene expression patterns may help to guide treatment decisions based on these unique correlative profiles of GBM. -tissue_expression_ns hsa-mir-612 Glioblastoma 23924460 The miRNA gene expression profiles correlate with several selected MRI features of patients with GBM. Further analysis of key imaging features of MRI with correlation with miRNA gene expression patterns may help to guide treatment decisions based on these unique correlative profiles of GBM. -tissue_expression_ns hsa-mir-210 Ischemia 23931770 "The physiopathological significance of miR-210 is context dependent. In the ischemic skeletal muscle it seems to be cytoprotective, regulating oxidative metabolism and oxidative stress." -tissue_expression_ns hsa-let-7g Colorectal Carcinoma 23932154 "Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g." -tissue_expression_ns hsa-mir-132 Colorectal Carcinoma 23932154 "Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g." -tissue_expression_ns hsa-mir-224 Colorectal Carcinoma 23932154 "Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g." -tissue_expression_ns hsa-mir-320a Colorectal Carcinoma 23932154 "Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g." -tissue_expression_ns hsa-mir-1280 Neoplasms [unspecific] 23936320 Characterization of microRNA expression profiles and the discovery of novel microRNAs involved in cancer during human embryonic development. -tissue_expression_ns hsa-mir-638 Neoplasms [unspecific] 23936320 Characterization of microRNA expression profiles and the discovery of novel microRNAs involved in cancer during human embryonic development. -tissue_expression_ns hsa-mir-720 Neoplasms [unspecific] 23936320 Characterization of microRNA expression profiles and the discovery of novel microRNAs involved in cancer during human embryonic development. -tissue_expression_ns hsa-mir-106b Bladder Neoplasms 23945108 miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome. -tissue_expression_ns hsa-mir-125b Bladder Neoplasms 23945108 miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome. -tissue_expression_ns hsa-mir-130a Bladder Neoplasms 23945108 miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome. -tissue_expression_ns hsa-mir-130b Bladder Neoplasms 23945108 miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome. -tissue_expression_ns hsa-mir-139 Bladder Neoplasms 23945108 miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome. -tissue_expression_ns hsa-mir-141 Bladder Neoplasms 23945108 miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome. -tissue_expression_ns hsa-mir-145 Bladder Neoplasms 23945108 miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome. -tissue_expression_ns hsa-mir-199a Bladder Neoplasms 23945108 miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome. -tissue_expression_ns hsa-mir-200a Bladder Neoplasms 23945108 miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome. -tissue_expression_ns hsa-mir-205 Bladder Neoplasms 23945108 miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome. -tissue_expression_ns hsa-mir-20a Bladder Neoplasms 23945108 miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome. -tissue_expression_ns hsa-mir-214 Bladder Neoplasms 23945108 miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome. -tissue_expression_ns hsa-mir-222 Bladder Neoplasms 23945108 miRNA profiling identifies candidate mirnas for bladder cancer diagnosis and clinical outcome. -tissue_expression_ns hsa-mir-650 "Adenocarcinoma, Lung" 23991130 miR-650 is a novel prognostic marker in LAD and its expression is a potential indicator of chemosensitivity to docetaxel-based chemotherapy regimen. -tissue_expression_ns hsa-mir-181b Oral Leukoplakia 24020903 some cytological and histopathological parameters used to grade dysplasia are associated with altered miRNA expression. -tissue_expression_ns hsa-mir-21 Oral Leukoplakia 24020903 some cytological and histopathological parameters used to grade dysplasia are associated with altered miRNA expression. -tissue_expression_ns hsa-mir-345 Oral Leukoplakia 24020903 some cytological and histopathological parameters used to grade dysplasia are associated with altered miRNA expression. -tissue_expression_ns hsa-mir-203 Melanoma 24023765 we found extensive sequence variations (isomiRs) and other non-coding small RNAs revealing a complex melanoma transcriptome. Deep-sequencing small RNAs directly from clinically defined specimens provides a robust strategy to improve melanoma diagnostics. -tissue_expression_ns hsa-mir-204 Melanoma 24023765 we found extensive sequence variations (isomiRs) and other non-coding small RNAs revealing a complex melanoma transcriptome. Deep-sequencing small RNAs directly from clinically defined specimens provides a robust strategy to improve melanoma diagnostics. -tissue_expression_ns hsa-mir-205 Melanoma 24023765 we found extensive sequence variations (isomiRs) and other non-coding small RNAs revealing a complex melanoma transcriptome. Deep-sequencing small RNAs directly from clinically defined specimens provides a robust strategy to improve melanoma diagnostics. -tissue_expression_ns hsa-mir-211 Melanoma 24023765 we found extensive sequence variations (isomiRs) and other non-coding small RNAs revealing a complex melanoma transcriptome. Deep-sequencing small RNAs directly from clinically defined specimens provides a robust strategy to improve melanoma diagnostics. -tissue_expression_ns hsa-mir-23b Melanoma 24023765 we found extensive sequence variations (isomiRs) and other non-coding small RNAs revealing a complex melanoma transcriptome. Deep-sequencing small RNAs directly from clinically defined specimens provides a robust strategy to improve melanoma diagnostics. -tissue_expression_ns hsa-mir-26a Melanoma 24023765 we found extensive sequence variations (isomiRs) and other non-coding small RNAs revealing a complex melanoma transcriptome. Deep-sequencing small RNAs directly from clinically defined specimens provides a robust strategy to improve melanoma diagnostics. -tissue_expression_ns hsa-mir-26b Melanoma 24023765 we found extensive sequence variations (isomiRs) and other non-coding small RNAs revealing a complex melanoma transcriptome. Deep-sequencing small RNAs directly from clinically defined specimens provides a robust strategy to improve melanoma diagnostics. -tissue_expression_ns hsa-mir-21 Gastric Neoplasms 24023850 miR-21 has potential diagnostic value with a moderate sensitivity and specificity for GC. More prospective studies on the diagnostic value of miR-21 for GC are needed in the future. -tissue_expression_ns hsa-mir-106b "Carcinoma, Gastric" 24040025 Candidate microRNA biomarkers in human gastric cancer: a systematic review and validation study. -tissue_expression_ns hsa-mir-17 "Carcinoma, Gastric" 24040025 Candidate microRNA biomarkers in human gastric cancer: a systematic review and validation study. -tissue_expression_ns hsa-mir-18a "Carcinoma, Gastric" 24040025 Candidate microRNA biomarkers in human gastric cancer: a systematic review and validation study. -tissue_expression_ns hsa-mir-20a "Carcinoma, Gastric" 24040025 Candidate microRNA biomarkers in human gastric cancer: a systematic review and validation study. -tissue_expression_ns hsa-mir-21 "Carcinoma, Gastric" 24040025 Candidate microRNA biomarkers in human gastric cancer: a systematic review and validation study. -tissue_expression_ns hsa-mir-378 "Carcinoma, Gastric" 24040025 Candidate microRNA biomarkers in human gastric cancer: a systematic review and validation study. -tissue_expression_ns hsa-mir-638 "Carcinoma, Gastric" 24040025 Candidate microRNA biomarkers in human gastric cancer: a systematic review and validation study. -tissue_expression_ns hsa-mir-196a Pancreatic Neoplasms 24048456 "Our results provide experimental evidence to support aberrant expression of miR-196a is associated with abnormal apoptosis, invasion, and proliferation of pancreatic cancer cells." -tissue_expression_ns hsa-mir-146a Inflammatory Bowel Diseases 24051693 "In summary,we demonstrate that miR-31, miR-206, miR-424, and miR-146a are novel specific biomarkers of inflammatory bowel disease." -tissue_expression_ns hsa-mir-206 Inflammatory Bowel Diseases 24051693 "In summary,we demonstrate that miR-31, miR-206, miR-424, and miR-146a are novel specific biomarkers of inflammatory bowel disease." -tissue_expression_ns hsa-mir-31 Inflammatory Bowel Diseases 24051693 "In summary,we demonstrate that miR-31, miR-206, miR-424, and miR-146a are novel specific biomarkers of inflammatory bowel disease." -tissue_expression_ns hsa-mir-424 Inflammatory Bowel Diseases 24051693 "In summary,we demonstrate that miR-31, miR-206, miR-424, and miR-146a are novel specific biomarkers of inflammatory bowel disease." -tissue_expression_ns hsa-mir-650 Glioma 24062138 MicroRNA-650 expression in glioma is associated with prognosis of patients. -tissue_expression_ns hsa-mir-21 Atrial Fibrillation 24069193 "The expression of miRNA-21 in human atrial tissue was found to be related to atrial fibrosis and might affect AF occurrence, indicating its usefulness as a biomarker for cardiac surgery management." -tissue_expression_ns hsa-let-7c Down Syndrome 24071828 Differentially expressed microRNAs may be involved in hemopoietic abnormalities and the immune defects of DS fetuses and newborns. -tissue_expression_ns hsa-mir-125b-2 Down Syndrome 24071828 Differentially expressed microRNAs may be involved in hemopoietic abnormalities and the immune defects of DS fetuses and newborns. -tissue_expression_ns hsa-mir-155 Down Syndrome 24071828 Differentially expressed microRNAs may be involved in hemopoietic abnormalities and the immune defects of DS fetuses and newborns. -tissue_expression_ns hsa-mir-802 Down Syndrome 24071828 Differentially expressed microRNAs may be involved in hemopoietic abnormalities and the immune defects of DS fetuses and newborns. -tissue_expression_ns hsa-mir-99a Down Syndrome 24071828 Differentially expressed microRNAs may be involved in hemopoietic abnormalities and the immune defects of DS fetuses and newborns. -tissue_expression_ns hsa-mir-106 Colorectal Carcinoma 24078989 MiRNAs might soon represent novel prognostic and diagnostic tools in patients at high risk of CRC or being diagnosed with CRC. -tissue_expression_ns hsa-mir-126 Colorectal Carcinoma 24078989 MiRNAs might soon represent novel prognostic and diagnostic tools in patients at high risk of CRC or being diagnosed with CRC. -tissue_expression_ns hsa-mir-21 Colorectal Carcinoma 24078989 MiRNAs might soon represent novel prognostic and diagnostic tools in patients at high risk of CRC or being diagnosed with CRC. -tissue_expression_ns hsa-mir-26b Colorectal Carcinoma 24078989 MiRNAs might soon represent novel prognostic and diagnostic tools in patients at high risk of CRC or being diagnosed with CRC. -tissue_expression_ns hsa-mir-328 Colorectal Carcinoma 24078989 MiRNAs might soon represent novel prognostic and diagnostic tools in patients at high risk of CRC or being diagnosed with CRC. -tissue_expression_ns hsa-mir-345 Colorectal Carcinoma 24078989 MiRNAs might soon represent novel prognostic and diagnostic tools in patients at high risk of CRC or being diagnosed with CRC. -tissue_expression_ns hsa-mir-92a Colorectal Carcinoma 24078989 MiRNAs might soon represent novel prognostic and diagnostic tools in patients at high risk of CRC or being diagnosed with CRC. -tissue_expression_ns hsa-mir-302b "Carcinoma, Hepatocellular" 24083596 miR-302b suppresses HCC growth may due to targeting the EGFR/AKT2/CCND1 pathway. -tissue_expression_ns hsa-mir-10a "Cardiomyopathy, Hypertrophic" 24083979 In silico identification of mRNA targets of differentially expressed miRNAs showed a large proportion of genes involved in cardiac hypertrophy and cardiac beta-adrenergic receptor signaling and we showed reduced phosphorylation of cardiac troponin I in the HCM myocardium when compared with donor. HCM patients with MYBPC3 mutations have a specific miRNA expression profile. Downstream mRNA targets reveal possible involvement in cardiac signaling pathways. -tissue_expression_ns hsa-mir-10b "Cardiomyopathy, Hypertrophic" 24083979 In silico identification of mRNA targets of differentially expressed miRNAs showed a large proportion of genes involved in cardiac hypertrophy and cardiac beta-adrenergic receptor signaling and we showed reduced phosphorylation of cardiac troponin I in the HCM myocardium when compared with donor. HCM patients with MYBPC3 mutations have a specific miRNA expression profile. Downstream mRNA targets reveal possible involvement in cardiac signaling pathways. -tissue_expression_ns hsa-mir-181a-2 "Cardiomyopathy, Hypertrophic" 24083979 In silico identification of mRNA targets of differentially expressed miRNAs showed a large proportion of genes involved in cardiac hypertrophy and cardiac beta-adrenergic receptor signaling and we showed reduced phosphorylation of cardiac troponin I in the HCM myocardium when compared with donor. HCM patients with MYBPC3 mutations have a specific miRNA expression profile. Downstream mRNA targets reveal possible involvement in cardiac signaling pathways. -tissue_expression_ns hsa-mir-184 "Cardiomyopathy, Hypertrophic" 24083979 In silico identification of mRNA targets of differentially expressed miRNAs showed a large proportion of genes involved in cardiac hypertrophy and cardiac beta-adrenergic receptor signaling and we showed reduced phosphorylation of cardiac troponin I in the HCM myocardium when compared with donor. HCM patients with MYBPC3 mutations have a specific miRNA expression profile. Downstream mRNA targets reveal possible involvement in cardiac signaling pathways. -tissue_expression_ns hsa-mir-204 "Cardiomyopathy, Hypertrophic" 24083979 In silico identification of mRNA targets of differentially expressed miRNAs showed a large proportion of genes involved in cardiac hypertrophy and cardiac beta-adrenergic receptor signaling and we showed reduced phosphorylation of cardiac troponin I in the HCM myocardium when compared with donor. HCM patients with MYBPC3 mutations have a specific miRNA expression profile. Downstream mRNA targets reveal possible involvement in cardiac signaling pathways. -tissue_expression_ns hsa-mir-222 "Cardiomyopathy, Hypertrophic" 24083979 In silico identification of mRNA targets of differentially expressed miRNAs showed a large proportion of genes involved in cardiac hypertrophy and cardiac beta-adrenergic receptor signaling and we showed reduced phosphorylation of cardiac troponin I in the HCM myocardium when compared with donor. HCM patients with MYBPC3 mutations have a specific miRNA expression profile. Downstream mRNA targets reveal possible involvement in cardiac signaling pathways. -tissue_expression_ns hsa-mir-34b "Cardiomyopathy, Hypertrophic" 24083979 In silico identification of mRNA targets of differentially expressed miRNAs showed a large proportion of genes involved in cardiac hypertrophy and cardiac beta-adrenergic receptor signaling and we showed reduced phosphorylation of cardiac troponin I in the HCM myocardium when compared with donor. HCM patients with MYBPC3 mutations have a specific miRNA expression profile. Downstream mRNA targets reveal possible involvement in cardiac signaling pathways. -tissue_expression_ns hsa-mir-371 "Cardiomyopathy, Hypertrophic" 24083979 In silico identification of mRNA targets of differentially expressed miRNAs showed a large proportion of genes involved in cardiac hypertrophy and cardiac beta-adrenergic receptor signaling and we showed reduced phosphorylation of cardiac troponin I in the HCM myocardium when compared with donor. HCM patients with MYBPC3 mutations have a specific miRNA expression profile. Downstream mRNA targets reveal possible involvement in cardiac signaling pathways. -tissue_expression_ns hsa-mir-383 "Cardiomyopathy, Hypertrophic" 24083979 In silico identification of mRNA targets of differentially expressed miRNAs showed a large proportion of genes involved in cardiac hypertrophy and cardiac beta-adrenergic receptor signaling and we showed reduced phosphorylation of cardiac troponin I in the HCM myocardium when compared with donor. HCM patients with MYBPC3 mutations have a specific miRNA expression profile. Downstream mRNA targets reveal possible involvement in cardiac signaling pathways. -tissue_expression_ns hsa-mir-497 "Cardiomyopathy, Hypertrophic" 24083979 In silico identification of mRNA targets of differentially expressed miRNAs showed a large proportion of genes involved in cardiac hypertrophy and cardiac beta-adrenergic receptor signaling and we showed reduced phosphorylation of cardiac troponin I in the HCM myocardium when compared with donor. HCM patients with MYBPC3 mutations have a specific miRNA expression profile. Downstream mRNA targets reveal possible involvement in cardiac signaling pathways. -tissue_expression_ns hsa-mir-708 "Cardiomyopathy, Hypertrophic" 24083979 In silico identification of mRNA targets of differentially expressed miRNAs showed a large proportion of genes involved in cardiac hypertrophy and cardiac beta-adrenergic receptor signaling and we showed reduced phosphorylation of cardiac troponin I in the HCM myocardium when compared with donor. HCM patients with MYBPC3 mutations have a specific miRNA expression profile. Downstream mRNA targets reveal possible involvement in cardiac signaling pathways. -tissue_expression_ns hsa-mir-96 "Cardiomyopathy, Hypertrophic" 24083979 In silico identification of mRNA targets of differentially expressed miRNAs showed a large proportion of genes involved in cardiac hypertrophy and cardiac beta-adrenergic receptor signaling and we showed reduced phosphorylation of cardiac troponin I in the HCM myocardium when compared with donor. HCM patients with MYBPC3 mutations have a specific miRNA expression profile. Downstream mRNA targets reveal possible involvement in cardiac signaling pathways. -tissue_expression_ns hsa-mir-150 Traumatic Brain Injury 24108763 neutrophils associated with traumatic injury were found to have a unique miRNA signature. Changes in signaling pathways due to deregulated miRNAs may be involved in the pathological processes of traumatic injury. -tissue_expression_ns hsa-mir-155 Traumatic Brain Injury 24108763 neutrophils associated with traumatic injury were found to have a unique miRNA signature. Changes in signaling pathways due to deregulated miRNAs may be involved in the pathological processes of traumatic injury. -tissue_expression_ns hsa-mir-223 Traumatic Brain Injury 24108763 neutrophils associated with traumatic injury were found to have a unique miRNA signature. Changes in signaling pathways due to deregulated miRNAs may be involved in the pathological processes of traumatic injury. -tissue_expression_ns hsa-mir-23a Traumatic Brain Injury 24108763 neutrophils associated with traumatic injury were found to have a unique miRNA signature. Changes in signaling pathways due to deregulated miRNAs may be involved in the pathological processes of traumatic injury. -tissue_expression_ns hsa-mir-30e Traumatic Brain Injury 24108763 neutrophils associated with traumatic injury were found to have a unique miRNA signature. Changes in signaling pathways due to deregulated miRNAs may be involved in the pathological processes of traumatic injury. -tissue_expression_ns hsa-mir-3945 Traumatic Brain Injury 24108763 neutrophils associated with traumatic injury were found to have a unique miRNA signature. Changes in signaling pathways due to deregulated miRNAs may be involved in the pathological processes of traumatic injury. -tissue_expression_ns hsa-mir-124a "Carcinoma, Lung, Non-Small-Cell" 24113142 The developed prediction algorithm is a valuable potential biomarker for assisting lung cancer diagnosis in minimal biopsy material. A prospective validation is required to measure the enhancement of diagnostic accuracy of our current clinical practice. -tissue_expression_ns hsa-mir-126 "Carcinoma, Lung, Non-Small-Cell" 24113142 The developed prediction algorithm is a valuable potential biomarker for assisting lung cancer diagnosis in minimal biopsy material. A prospective validation is required to measure the enhancement of diagnostic accuracy of our current clinical practice. -tissue_expression_ns hsa-mir-200c "Carcinoma, Lung, Non-Small-Cell" 24113142 The developed prediction algorithm is a valuable potential biomarker for assisting lung cancer diagnosis in minimal biopsy material. A prospective validation is required to measure the enhancement of diagnostic accuracy of our current clinical practice. -tissue_expression_ns hsa-mir-34 "Carcinoma, Lung, Non-Small-Cell" 24113142 The developed prediction algorithm is a valuable potential biomarker for assisting lung cancer diagnosis in minimal biopsy material. A prospective validation is required to measure the enhancement of diagnostic accuracy of our current clinical practice. -tissue_expression_ns hsa-mir-9 "Carcinoma, Lung, Non-Small-Cell" 24113142 The developed prediction algorithm is a valuable potential biomarker for assisting lung cancer diagnosis in minimal biopsy material. A prospective validation is required to measure the enhancement of diagnostic accuracy of our current clinical practice. -tissue_expression_ns hsa-mir-141 "Carcinoma, Renal Cell" 24129247 "Expression analysis of miR-141 or miR-200b accurately distinguished RCTs from normal renal tissues, oncocytoma from RCC and chRCC from oncocytoma. The diagnostic performance was confirmed in the validation set. Interestingly,miR-21, miR-141 and miR-155 expression levels showed prognostic significance in a univariate analysis." -tissue_expression_ns hsa-mir-155 "Carcinoma, Renal Cell" 24129247 "Expression analysis of miR-141 or miR-200b accurately distinguished RCTs from normal renal tissues, oncocytoma from RCC and chRCC from oncocytoma. The diagnostic performance was confirmed in the validation set. Interestingly,miR-21, miR-141 and miR-155 expression levels showed prognostic significance in a univariate analysis." -tissue_expression_ns hsa-mir-21 "Carcinoma, Renal Cell" 24129247 "Expression analysis of miR-141 or miR-200b accurately distinguished RCTs from normal renal tissues, oncocytoma from RCC and chRCC from oncocytoma. The diagnostic performance was confirmed in the validation set. Interestingly,miR-21, miR-141 and miR-155 expression levels showed prognostic significance in a univariate analysis." -tissue_expression_ns hsa-mir-143 Vascular Disease [unspecific] 24166492 The flank sequences of miR-145 and miR-143 play a critical role in their aberrant expression in VSMCs and vascular walls. The genetically engineered smart miRNAs based on their flank sequences may have broadly therapeutic applications for many vascular diseases. -tissue_expression_ns hsa-mir-145 Vascular Disease [unspecific] 24166492 The flank sequences of miR-145 and miR-143 play a critical role in their aberrant expression in VSMCs and vascular walls. The genetically engineered smart miRNAs based on their flank sequences may have broadly therapeutic applications for many vascular diseases. -tissue_expression_ns hsa-mir-205 Prostate Neoplasms 24167554 MicroRNA profiling in prostate cancer--the diagnostic potential of urinary miR-205 and miR-214. -tissue_expression_ns hsa-mir-214 Prostate Neoplasms 24167554 MicroRNA profiling in prostate cancer--the diagnostic potential of urinary miR-205 and miR-214. -tissue_expression_ns hsa-mir-204 Breast Neoplasms 24191129 "The expression and the functional role of several miRNAs (miR-206, miR-31, miR-27a/b, miR-21, miR-92a, miR-205, miR-125a/b, miR-10b, miR-155, miR-146a/b, miR-335, miR-204, miR-211, miR-7, miR-22, miR-126, and miR-17) in breast cancer has been identified." -tissue_expression_ns hsa-mir-10b Breast Neoplasms 24196612 microRNA expression in breast development and breast cancer] -tissue_expression_ns hsa-mir-210 Breast Neoplasms 24196612 microRNA expression in breast development and breast cancer] -tissue_expression_ns hsa-mir-31 Breast Neoplasms 24196612 microRNA expression in breast development and breast cancer] -tissue_expression_ns hsa-mir-335 Breast Neoplasms 24196612 microRNA expression in breast development and breast cancer] -tissue_expression_ns hsa-mir-1287 Laryngeal Neoplasms 24238754 Identification of predictive biomarkers for early diagnosis of larynx carcinoma based on microRNA expression data. -tissue_expression_ns hsa-mir-657 Laryngeal Neoplasms 24238754 Identification of predictive biomarkers for early diagnosis of larynx carcinoma based on microRNA expression data. -tissue_expression_ns hsa-mir-129 Psychiatric Disorders 24246224 Metabolic stress-induced microRNA and mRNA expression profiles of human fibroblasts. -tissue_expression_ns hsa-mir-146b Psychiatric Disorders 24246224 Metabolic stress-induced microRNA and mRNA expression profiles of human fibroblasts. -tissue_expression_ns hsa-mir-543 Psychiatric Disorders 24246224 Metabolic stress-induced microRNA and mRNA expression profiles of human fibroblasts. -tissue_expression_ns hsa-mir-550a Psychiatric Disorders 24246224 Metabolic stress-induced microRNA and mRNA expression profiles of human fibroblasts. -tissue_expression_ns hsa-let-7a "Carcinoma, Hepatocellular, HBV-Related" 24273923 Analysis of microRNA expression profiles in human hepatitis B virus-related hepatocellular carcinoma. -tissue_expression_ns hsa-let-7c "Carcinoma, Hepatocellular, HBV-Related" 24273923 Analysis of microRNA expression profiles in human hepatitis B virus-related hepatocellular carcinoma. -tissue_expression_ns hsa-mir-138 "Carcinoma, Hepatocellular, HBV-Related" 24273923 Analysis of microRNA expression profiles in human hepatitis B virus-related hepatocellular carcinoma. -tissue_expression_ns hsa-mir-183 "Carcinoma, Hepatocellular, HBV-Related" 24273923 Analysis of microRNA expression profiles in human hepatitis B virus-related hepatocellular carcinoma. -tissue_expression_ns hsa-mir-196a "Carcinoma, Hepatocellular, HBV-Related" 24273923 Analysis of microRNA expression profiles in human hepatitis B virus-related hepatocellular carcinoma. -tissue_expression_ns hsa-mir-96 "Carcinoma, Hepatocellular, HBV-Related" 24273923 Analysis of microRNA expression profiles in human hepatitis B virus-related hepatocellular carcinoma. -tissue_expression_ns hsa-mir-330 Neoplasms [unspecific] 24278004 MicroRNA-gene association as a prognostic biomarker in cancer exposes disease mechanisms. -tissue_expression_ns hsa-mir-143 "Carcinoma, Lung, Non-Small-Cell" 24286416 "It is indicated that there is a potential for using miR-143 as a novel diagnostic biomarker for NSCLC. Moreover, miR-150 can be a highly accurate marker for differentiating adenocarcinoma from squamous cell carcinoma." -tissue_expression_ns hsa-mir-150 "Carcinoma, Lung, Non-Small-Cell" 24286416 "It is indicated that there is a potential for using miR-143 as a novel diagnostic biomarker for NSCLC. Moreover, miR-150 can be a highly accurate marker for differentiating adenocarcinoma from squamous cell carcinoma." -tissue_expression_ns hsa-let-7f Bronchopulmonary Dysplasia 24301780 MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis. -tissue_expression_ns hsa-mir-130b Bronchopulmonary Dysplasia 24301780 MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis. -tissue_expression_ns hsa-mir-141 Bronchopulmonary Dysplasia 24301780 MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis. -tissue_expression_ns hsa-mir-146b Bronchopulmonary Dysplasia 24301780 MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis. -tissue_expression_ns hsa-mir-21 Bronchopulmonary Dysplasia 24301780 MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis. -tissue_expression_ns hsa-mir-214 Bronchopulmonary Dysplasia 24301780 MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis. -tissue_expression_ns hsa-mir-29a Bronchopulmonary Dysplasia 24301780 MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis. -tissue_expression_ns hsa-mir-34a Bronchopulmonary Dysplasia 24301780 MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis. -tissue_expression_ns hsa-mir-382 Bronchopulmonary Dysplasia 24301780 MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis. -tissue_expression_ns hsa-mir-411 Bronchopulmonary Dysplasia 24301780 MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis. -tissue_expression_ns hsa-mir-431 Bronchopulmonary Dysplasia 24301780 MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis. -tissue_expression_ns hsa-mir-503 Bronchopulmonary Dysplasia 24301780 MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis. -tissue_expression_ns hsa-mir-10b Pituitary Adenoma 24310454 "We established miRNA expression maps of non-functioning and gonadotropin-secreting pituitary adenomas. The most strongly differentially expressed genes were miR-124a and miR-31 in non-functioning pituitary adenomas, and miR-10b and miR-503 in gonadotropin-secreting pituitary adenomas." -tissue_expression_ns hsa-mir-422a Pituitary Adenoma 24310454 "We established miRNA expression maps of non-functioning and gonadotropin-secreting pituitary adenomas. The most strongly differentially expressed genes were miR-124a and miR-31 in non-functioning pituitary adenomas, and miR-10b and miR-503 in gonadotropin-secreting pituitary adenomas." -tissue_expression_ns hsa-mir-422b Pituitary Adenoma 24310454 "We established miRNA expression maps of non-functioning and gonadotropin-secreting pituitary adenomas. The most strongly differentially expressed genes were miR-124a and miR-31 in non-functioning pituitary adenomas, and miR-10b and miR-503 in gonadotropin-secreting pituitary adenomas." -tissue_expression_ns hsa-mir-520b Pituitary Adenoma 24310454 "We established miRNA expression maps of non-functioning and gonadotropin-secreting pituitary adenomas. The most strongly differentially expressed genes were miR-124a and miR-31 in non-functioning pituitary adenomas, and miR-10b and miR-503 in gonadotropin-secreting pituitary adenomas." -tissue_expression_ns hsa-mir-523 Pituitary Adenoma 24310454 "We established miRNA expression maps of non-functioning and gonadotropin-secreting pituitary adenomas. The most strongly differentially expressed genes were miR-124a and miR-31 in non-functioning pituitary adenomas, and miR-10b and miR-503 in gonadotropin-secreting pituitary adenomas." -tissue_expression_ns hsa-mir-146b Thyroid Lymphoma 24327568 "Histotype-specific miRNA signatures can provide new insight into the molecular mechanisms of thyroid carcinogenesis. The tested 4-miRNA signature is a promising diagnostic tool for differentiating ATC from PTL and non-neoplastic MNG, even in the presence of scant material obtained from minimally invasive procedures." -tissue_expression_ns hsa-mir-221 Thyroid Lymphoma 24327568 "Histotype-specific miRNA signatures can provide new insight into the molecular mechanisms of thyroid carcinogenesis. The tested 4-miRNA signature is a promising diagnostic tool for differentiating ATC from PTL and non-neoplastic MNG, even in the presence of scant material obtained from minimally invasive procedures." -tissue_expression_ns hsa-mir-222 Thyroid Lymphoma 24327568 "Histotype-specific miRNA signatures can provide new insight into the molecular mechanisms of thyroid carcinogenesis. The tested 4-miRNA signature is a promising diagnostic tool for differentiating ATC from PTL and non-neoplastic MNG, even in the presence of scant material obtained from minimally invasive procedures." -tissue_expression_ns hsa-mir-26a Thyroid Lymphoma 24327568 "Histotype-specific miRNA signatures can provide new insight into the molecular mechanisms of thyroid carcinogenesis. The tested 4-miRNA signature is a promising diagnostic tool for differentiating ATC from PTL and non-neoplastic MNG, even in the presence of scant material obtained from minimally invasive procedures." -tissue_expression_ns hsa-let-7g "Carcinoma, Renal Cell, Clear-Cell" 24351440 "MicroRNA expression signatures of stage, grade, and progression in clear cell RCC." -tissue_expression_ns hsa-mir-142 "Carcinoma, Renal Cell, Clear-Cell" 24351440 "MicroRNA expression signatures of stage, grade, and progression in clear cell RCC." -tissue_expression_ns hsa-mir-204 "Carcinoma, Renal Cell, Clear-Cell" 24351440 "MicroRNA expression signatures of stage, grade, and progression in clear cell RCC." -tissue_expression_ns hsa-mir-21 "Carcinoma, Renal Cell, Clear-Cell" 24351440 "MicroRNA expression signatures of stage, grade, and progression in clear cell RCC." -tissue_expression_ns hsa-mir-424 "Carcinoma, Renal Cell, Clear-Cell" 24351440 "MicroRNA expression signatures of stage, grade, and progression in clear cell RCC." -tissue_expression_ns hsa-mir-129-2 "Lymphoma, Large B-Cell" 24358187 MicroRNA profiling of primary cutaneous large B-cell lymphomas. -tissue_expression_ns hsa-mir-214 "Lymphoma, Large B-Cell" 24358187 MicroRNA profiling of primary cutaneous large B-cell lymphomas. -tissue_expression_ns hsa-mir-31 "Lymphoma, Large B-Cell" 24358187 MicroRNA profiling of primary cutaneous large B-cell lymphomas. -tissue_expression_ns hsa-mir-9 "Lymphoma, Large B-Cell" 24358187 MicroRNA profiling of primary cutaneous large B-cell lymphomas. -tissue_expression_ns hsa-mir-17 "Squamous Cell Carcinoma, Esophageal" 24360091 "miR-17, miR-18a, and miR-19a can serve as potential unfavorable prognostic biomarkers in ESCC which are associated with some clinicopathologic factors" -tissue_expression_ns hsa-mir-18a "Squamous Cell Carcinoma, Esophageal" 24360091 "miR-17, miR-18a, and miR-19a can serve as potential unfavorable prognostic biomarkers in ESCC which are associated with some clinicopathologic factors" -tissue_expression_ns hsa-mir-19a "Squamous Cell Carcinoma, Esophageal" 24360091 "miR-17, miR-18a, and miR-19a can serve as potential unfavorable prognostic biomarkers in ESCC which are associated with some clinicopathologic factors" -tissue_expression_ns hsa-mir-141 "Carcinoma, Endometrial" 24363810 Aberrant microRNA expression in endometrial carcinoma using formalin-fixed paraffin-embedded (FFPE) tissues. -tissue_expression_ns hsa-mir-182 "Carcinoma, Endometrial" 24363810 Aberrant microRNA expression in endometrial carcinoma using formalin-fixed paraffin-embedded (FFPE) tissues. -tissue_expression_ns hsa-mir-200a "Carcinoma, Endometrial" 24363810 Aberrant microRNA expression in endometrial carcinoma using formalin-fixed paraffin-embedded (FFPE) tissues. -tissue_expression_ns hsa-mir-200b "Carcinoma, Endometrial" 24363810 Aberrant microRNA expression in endometrial carcinoma using formalin-fixed paraffin-embedded (FFPE) tissues. -tissue_expression_ns hsa-mir-205 "Carcinoma, Endometrial" 24363810 Aberrant microRNA expression in endometrial carcinoma using formalin-fixed paraffin-embedded (FFPE) tissues. -tissue_expression_ns hsa-mir-1323 "Carcinoma, Nasopharyngeal" 24367666 Genome-wide analyses of radioresistance-associated miRNA expression profile in nasopharyngeal carcinoma using next generation deep sequencing. -tissue_expression_ns hsa-mir-324 "Carcinoma, Nasopharyngeal" 24367666 Genome-wide analyses of radioresistance-associated miRNA expression profile in nasopharyngeal carcinoma using next generation deep sequencing. -tissue_expression_ns hsa-mir-34c "Carcinoma, Nasopharyngeal" 24367666 Genome-wide analyses of radioresistance-associated miRNA expression profile in nasopharyngeal carcinoma using next generation deep sequencing. -tissue_expression_ns hsa-mir-371a "Carcinoma, Nasopharyngeal" 24367666 Genome-wide analyses of radioresistance-associated miRNA expression profile in nasopharyngeal carcinoma using next generation deep sequencing. -tissue_expression_ns hsa-mir-4501 "Carcinoma, Nasopharyngeal" 24367666 Genome-wide analyses of radioresistance-associated miRNA expression profile in nasopharyngeal carcinoma using next generation deep sequencing. -tissue_expression_ns hsa-mir-93 "Carcinoma, Nasopharyngeal" 24367666 Genome-wide analyses of radioresistance-associated miRNA expression profile in nasopharyngeal carcinoma using next generation deep sequencing. -tissue_expression_ns hsa-mir-145 Liposarcoma 24375455 MicroRNA expression profiles distinguish liposarcoma subtypes and implicate miR-145 and miR-451 as tumor suppressors. -tissue_expression_ns hsa-mir-451 Liposarcoma 24375455 MicroRNA expression profiles distinguish liposarcoma subtypes and implicate miR-145 and miR-451 as tumor suppressors. -tissue_expression_ns hsa-mir-135a Polycystic Ovarian Syndrome 24390626 Altered microRNA and gene expression in the follicular fluid of women with polycystic ovary syndrome. -tissue_expression_ns hsa-mir-18b Polycystic Ovarian Syndrome 24390626 Altered microRNA and gene expression in the follicular fluid of women with polycystic ovary syndrome. -tissue_expression_ns hsa-mir-32 Polycystic Ovarian Syndrome 24390626 Altered microRNA and gene expression in the follicular fluid of women with polycystic ovary syndrome. -tissue_expression_ns hsa-mir-34c Polycystic Ovarian Syndrome 24390626 Altered microRNA and gene expression in the follicular fluid of women with polycystic ovary syndrome. -tissue_expression_ns hsa-mir-9 Polycystic Ovarian Syndrome 24390626 Altered microRNA and gene expression in the follicular fluid of women with polycystic ovary syndrome. -tissue_expression_ns hsa-mir-34a Glioblastoma 24412053 "Comparing miRNA expression between glioblastoma group and gliomas of grades I-III, 3 miRNAs (miR-10b, mir-34a and miR-101) showed different regulation statuses between high-grade and low-grade tumors." -tissue_expression_ns hsa-mir-23b Myotonic Muscular Dystrophy 24412363 "The Mef2 transcription network is disrupted in myotonic dystrophy heart tissue,dramatically altering miRNA and mRNA expression." -tissue_expression_ns hsa-mir-16 Parkinson Disease 24427314 "We identified a total of 761 genes and 24 miRNAs that were misregulated in the absence of LRRK2 when a false discovery rate of 0.2 was applied. Notably, most changes in gene expression were modest (i.e., <2 fold). By real-time quantitative RT-PCR, we confirmed the variations of selected genes (e.g., adra2, syt2, opalin) and miRNAs (e.g., miR-16, miR-25)." -tissue_expression_ns hsa-mir-126 "Carcinoma, Renal Cell" 24428907 A combined expression level of miR-21 and miR-126 accurately predicted CSS in two independent RCC cohorts and seems feasible for clinical application in assessing prognosis. -tissue_expression_ns hsa-mir-21 "Carcinoma, Renal Cell" 24428907 A combined expression level of miR-21 and miR-126 accurately predicted CSS in two independent RCC cohorts and seems feasible for clinical application in assessing prognosis. -tissue_expression_ns hsa-mir-146a Liver Neoplasms 24431000 Aberrant miRNA expression response to UV irradiation in human liver cancer cells. -tissue_expression_ns hsa-mir-21 Liver Neoplasms 24431000 Aberrant miRNA expression response to UV irradiation in human liver cancer cells. -tissue_expression_ns hsa-mir-26a Liver Neoplasms 24431000 Aberrant miRNA expression response to UV irradiation in human liver cancer cells. -tissue_expression_ns hsa-mir-34a Liver Neoplasms 24431000 Aberrant miRNA expression response to UV irradiation in human liver cancer cells. -tissue_expression_ns hsa-let-7 Prostate Neoplasms 24431212 Aberrant microRNA expression likely controls RAS oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic. -tissue_expression_ns hsa-mir-134 Prostate Neoplasms 24431212 Aberrant microRNA expression likely controls RAS oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic. -tissue_expression_ns hsa-mir-138 Prostate Neoplasms 24431212 Aberrant microRNA expression likely controls RAS oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic. -tissue_expression_ns hsa-mir-143 Prostate Neoplasms 24431212 Aberrant microRNA expression likely controls RAS oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic. -tissue_expression_ns hsa-mir-155 Prostate Neoplasms 24431212 Aberrant microRNA expression likely controls RAS oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic. -tissue_expression_ns hsa-mir-181c Prostate Neoplasms 24431212 Aberrant microRNA expression likely controls RAS oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic. -tissue_expression_ns hsa-mir-181d Prostate Neoplasms 24431212 Aberrant microRNA expression likely controls RAS oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic. -tissue_expression_ns hsa-mir-205 Prostate Neoplasms 24431212 Aberrant microRNA expression likely controls RAS oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic. -tissue_expression_ns hsa-mir-34c Prostate Neoplasms 24431212 Aberrant microRNA expression likely controls RAS oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic. -tissue_expression_ns hsa-mir-373 Prostate Neoplasms 24431212 Aberrant microRNA expression likely controls RAS oncogene activation during malignant transformation of human prostate epithelial and stem cells by arsenic. -tissue_expression_ns hsa-mir-10a Urinary Bladder Cancer 24439061 The role of microRNA profiling in prognosticating progression in Ta and T1 urinary bladder cancer. -tissue_expression_ns hsa-mir-31 Urinary Bladder Cancer 24439061 The role of microRNA profiling in prognosticating progression in Ta and T1 urinary bladder cancer. -tissue_expression_ns hsa-mir-10b Breast Neoplasms 24440078 Detection of miRNA expression in intact cells using activatable sensor oligonucleotides. -tissue_expression_ns hsa-mir-10b Breast Neoplasms 24440980 "MiR-21, -155, -222 and -10b are reliable candidate biomarkers for detection of breast cancer." -tissue_expression_ns hsa-mir-155 Breast Neoplasms 24440980 "MiR-21, -155, -222 and -10b are reliable candidate biomarkers for detection of breast cancer." -tissue_expression_ns hsa-mir-21 Breast Neoplasms 24440980 "MiR-21, -155, -222 and -10b are reliable candidate biomarkers for detection of breast cancer." -tissue_expression_ns hsa-mir-222 Breast Neoplasms 24440980 "MiR-21, -155, -222 and -10b are reliable candidate biomarkers for detection of breast cancer." -tissue_expression_ns hsa-mir-150 "Carcinoma, Thyroid" 24443580 MicroRNA profile of poorly differentiated thyroid carcinomas: new diagnostic and prognostic insights. -tissue_expression_ns hsa-mir-23b "Carcinoma, Thyroid" 24443580 MicroRNA profile of poorly differentiated thyroid carcinomas: new diagnostic and prognostic insights. -tissue_expression_ns hsa-mir-10b "Carcinoma, Lung, Non-Small-Cell" 24448358 "Expression of miR-128, -10b, -502-3p and -192 differed between SCC and AC, and miR-128 and -192 - between NLP and NSCLC." -tissue_expression_ns hsa-mir-128 "Carcinoma, Lung, Non-Small-Cell" 24448358 "Expression of miR-128, -10b, -502-3p and -192 differed between SCC and AC, and miR-128 and -192 - between NLP and NSCLC." -tissue_expression_ns hsa-mir-192 "Carcinoma, Lung, Non-Small-Cell" 24448358 "Expression of miR-128, -10b, -502-3p and -192 differed between SCC and AC, and miR-128 and -192 - between NLP and NSCLC." -tissue_expression_ns hsa-mir-502 "Carcinoma, Lung, Non-Small-Cell" 24448358 "Expression of miR-128, -10b, -502-3p and -192 differed between SCC and AC, and miR-128 and -192 - between NLP and NSCLC." -tissue_expression_ns hsa-mir-662 "Carcinoma, Lung, Non-Small-Cell" 24448358 "Of these six miRNAs, miR-662, -192 and -192* were confirmed as prognostic in the independent SCC cohort." -tissue_expression_ns hsa-let-7 Prostate Neoplasms 24452514 Comprehensive microRNA profiling of prostate cancer cells after ionizing radiation treatment. -tissue_expression_ns hsa-mir-1 Prostate Neoplasms 24452514 Comprehensive microRNA profiling of prostate cancer cells after ionizing radiation treatment. -tissue_expression_ns hsa-mir-106b Prostate Neoplasms 24452514 Comprehensive microRNA profiling of prostate cancer cells after ionizing radiation treatment. -tissue_expression_ns hsa-mir-125b Prostate Neoplasms 24452514 Comprehensive microRNA profiling of prostate cancer cells after ionizing radiation treatment. -tissue_expression_ns hsa-mir-205 Prostate Neoplasms 24452514 Comprehensive microRNA profiling of prostate cancer cells after ionizing radiation treatment. -tissue_expression_ns hsa-mir-20a Prostate Neoplasms 24452514 Comprehensive microRNA profiling of prostate cancer cells after ionizing radiation treatment. -tissue_expression_ns hsa-mir-21 Prostate Neoplasms 24452514 Comprehensive microRNA profiling of prostate cancer cells after ionizing radiation treatment. -tissue_expression_ns hsa-mir-34a Prostate Neoplasms 24452514 Comprehensive microRNA profiling of prostate cancer cells after ionizing radiation treatment. -tissue_expression_ns hsa-mir-521 Prostate Neoplasms 24452514 Comprehensive microRNA profiling of prostate cancer cells after ionizing radiation treatment. -tissue_expression_ns hsa-mir-155 "Carcinoma, Lung, Non-Small-Cell" 24460255 "the miR-155 expression level plays a prognostic role in patients with cancer, especially NSCLCs and digestive system carcinomas." -tissue_expression_ns hsa-mir-1 Atrial Fibrillation 24461008 AF alters the miRNA expression profiles of the left atria of MS patients. These findings may be useful for the biological understanding of AF in MS patients. -tissue_expression_ns hsa-mir-26a Atrial Fibrillation 24461008 AF alters the miRNA expression profiles of the left atria of MS patients. These findings may be useful for the biological understanding of AF in MS patients. -tissue_expression_ns hsa-mir-3613 Atrial Fibrillation 24461008 AF alters the miRNA expression profiles of the left atria of MS patients. These findings may be useful for the biological understanding of AF in MS patients. -tissue_expression_ns hsa-mir-466 Atrial Fibrillation 24461008 AF alters the miRNA expression profiles of the left atria of MS patients. These findings may be useful for the biological understanding of AF in MS patients. -tissue_expression_ns hsa-mir-574 Atrial Fibrillation 24461008 AF alters the miRNA expression profiles of the left atria of MS patients. These findings may be useful for the biological understanding of AF in MS patients. -tissue_expression_ns hsa-mir-146a Mycobacterium Avium Complex Disease 24462562 Analysis of miRNA expression profiling in human macrophages responding to Mycobacterium infection: induction of the immune regulator miR-146a. -tissue_expression_ns hsa-mir-17 Leukemia 24479800 "Aberrant expression of oncogenic miRNAs, including miR-155, miR-17-92, miR-21, miR-125b, miR-93, miR-143-p3, miR-196b, and miR-223 promotes leukemogenesis through increasing the leukemic stem/progenitor cell population, promoting cell proliferation, blocking cell differentiation, and diminishing cell apoptosis." -tissue_expression_ns hsa-mir-133 Polycystic Kidney Disease 24489795 "We found that in ADPKD urine specimens, miRNA previously implicated as kidney tumor suppressors (miR-1 and miR-133), as well as miRNA of presumed inflammatory and fibroblast cell origin (miR-223/miR-199), are dysregulated when compared to other CKD patients. Concordant with findings in the primary tubule epithelial cell model, this suggests roles for dysregulated miRNA in ADPKD pathogenesis and potential use as biomarkers. We intend to assess prognostic potential of miRNA in a followup analysis." -tissue_expression_ns hsa-mir-143 Polycystic Kidney Disease 24489795 "We found that in ADPKD urine specimens, miRNA previously implicated as kidney tumor suppressors (miR-1 and miR-133), as well as miRNA of presumed inflammatory and fibroblast cell origin (miR-223/miR-199), are dysregulated when compared to other CKD patients. Concordant with findings in the primary tubule epithelial cell model, this suggests roles for dysregulated miRNA in ADPKD pathogenesis and potential use as biomarkers. We intend to assess prognostic potential of miRNA in a followup analysis." -tissue_expression_ns hsa-mir-199 Polycystic Kidney Disease 24489795 "We found that in ADPKD urine specimens, miRNA previously implicated as kidney tumor suppressors (miR-1 and miR-133), as well as miRNA of presumed inflammatory and fibroblast cell origin (miR-223/miR-199), are dysregulated when compared to other CKD patients. Concordant with findings in the primary tubule epithelial cell model, this suggests roles for dysregulated miRNA in ADPKD pathogenesis and potential use as biomarkers. We intend to assess prognostic potential of miRNA in a followup analysis." -tissue_expression_ns hsa-mir-205 Polycystic Kidney Disease 24489795 "We found that in ADPKD urine specimens, miRNA previously implicated as kidney tumor suppressors (miR-1 and miR-133), as well as miRNA of presumed inflammatory and fibroblast cell origin (miR-223/miR-199), are dysregulated when compared to other CKD patients. Concordant with findings in the primary tubule epithelial cell model, this suggests roles for dysregulated miRNA in ADPKD pathogenesis and potential use as biomarkers. We intend to assess prognostic potential of miRNA in a followup analysis." -tissue_expression_ns hsa-mir-223 Polycystic Kidney Disease 24489795 "We found that in ADPKD urine specimens, miRNA previously implicated as kidney tumor suppressors (miR-1 and miR-133), as well as miRNA of presumed inflammatory and fibroblast cell origin (miR-223/miR-199), are dysregulated when compared to other CKD patients. Concordant with findings in the primary tubule epithelial cell model, this suggests roles for dysregulated miRNA in ADPKD pathogenesis and potential use as biomarkers. We intend to assess prognostic potential of miRNA in a followup analysis." -tissue_expression_ns hsa-mir-141 Colorectal Carcinoma 24510588 "miR-200a, miR-200c, miR-141, and miR-429 expression levels may identify CRC patients, including those with stage II disease, who are most likely to benefit from adjuvant chemotherapy." -tissue_expression_ns hsa-mir-200a Colorectal Carcinoma 24510588 "miR-200a, miR-200c, miR-141, and miR-429 expression levels may identify CRC patients, including those with stage II disease, who are most likely to benefit from adjuvant chemotherapy." -tissue_expression_ns hsa-mir-200c Colorectal Carcinoma 24510588 "miR-200a, miR-200c, miR-141, and miR-429 expression levels may identify CRC patients, including those with stage II disease, who are most likely to benefit from adjuvant chemotherapy." -tissue_expression_ns hsa-mir-128 Neoplasms [unspecific] 24515752 Microvesicle-associated microRNA expression is altered upon particulate matter exposure in healthy workers and in A549 cells. -tissue_expression_ns hsa-mir-302c Neoplasms [unspecific] 24515752 Microvesicle-associated microRNA expression is altered upon particulate matter exposure in healthy workers and in A549 cells. -tissue_expression_ns hsa-mir-143 "Carcinoma, Cervical" 24517947 "It seemed that miR-143 play an important role in the processes of generation and progression of cervical cancer. However, there was no significant difference found between the different ethnic groups. The expression level of miR-143 might serve as a valuable adjuvant parameter for diagnosing and predicting the state of cervical cancer." -tissue_expression_ns hsa-mir-182 Prostate Neoplasms 24518785 Results show that miR-182 and 187 are promising biomarkers for prostate cancer prognosis to identify patients at risk for progression and for diagnosis to improve the predictive capability of existing biomarkers. -tissue_expression_ns hsa-mir-187 Prostate Neoplasms 24518785 Results show that miR-182 and 187 are promising biomarkers for prostate cancer prognosis to identify patients at risk for progression and for diagnosis to improve the predictive capability of existing biomarkers. -tissue_expression_ns hsa-mir-363 Colorectal Carcinoma 24519049 The expression pattern in female is different from that in male.miR-363 and miR-490-5p possess the potential in screening colorectal cancer patients from healthy people. -tissue_expression_ns hsa-mir-490 Colorectal Carcinoma 24519049 The expression pattern in female is different from that in male.miR-363 and miR-490-5p possess the potential in screening colorectal cancer patients from healthy people. -tissue_expression_ns hsa-mir-195 Bladder Neoplasms 24520312 The microRNA expression signature of bladder cancer by deep sequencing: the functional significance of the miR-195/497 cluster. -tissue_expression_ns hsa-mir-497 Bladder Neoplasms 24520312 The microRNA expression signature of bladder cancer by deep sequencing: the functional significance of the miR-195/497 cluster. -tissue_expression_ns hsa-mir-133a Neuroendocrine Tumors 24535468 Establishment of robust controls for the normalization of miRNA expression in neuroendocrine tumors of the ileum and pancreas. -tissue_expression_ns hsa-mir-191 Neuroendocrine Tumors 24535468 Establishment of robust controls for the normalization of miRNA expression in neuroendocrine tumors of the ileum and pancreas. -tissue_expression_ns hsa-mir-93 Neuroendocrine Tumors 24535468 Establishment of robust controls for the normalization of miRNA expression in neuroendocrine tumors of the ileum and pancreas. -tissue_expression_ns hsa-mir-92a Colorectal Carcinoma 24551148 "MicroRNA-92a might be a novel potential biomarker in the diagnosis of colorectal cancer, and more studies are needed to highlight the theoretical strengths." -tissue_expression_ns hsa-mir-155 Autoimmune Thyroiditis 24554510 microRNA expressions in CD4+ and CD8+ T-cell subsets in autoimmune thyroid diseases. -tissue_expression_ns hsa-mir-200a Autoimmune Thyroiditis 24554510 microRNA expressions in CD4+ and CD8+ T-cell subsets in autoimmune thyroid diseases. -tissue_expression_ns hsa-mir-196a "Carcinoma, Periampullary" 24555977 "Differentially expressed common miRNA signatures identified in PAC subgroups may have a role in pathogenesis of PAC and miR-375, miR-31 and miR-196a expression patterns may differentiate PAC subtypes." -tissue_expression_ns hsa-mir-31 "Carcinoma, Periampullary" 24555977 "Differentially expressed common miRNA signatures identified in PAC subgroups may have a role in pathogenesis of PAC and miR-375, miR-31 and miR-196a expression patterns may differentiate PAC subtypes." -tissue_expression_ns hsa-mir-375 "Carcinoma, Periampullary" 24555977 "Differentially expressed common miRNA signatures identified in PAC subgroups may have a role in pathogenesis of PAC and miR-375, miR-31 and miR-196a expression patterns may differentiate PAC subtypes." -tissue_expression_ns hsa-mir-122 Hepatoblastoma 24570391 MicroRNA expression might predict prognosis of epithelial hepatoblastoma. -tissue_expression_ns hsa-mir-140 Hepatoblastoma 24570391 MicroRNA expression might predict prognosis of epithelial hepatoblastoma. -tissue_expression_ns hsa-mir-17 Hepatoblastoma 24570391 MicroRNA expression might predict prognosis of epithelial hepatoblastoma. -tissue_expression_ns hsa-mir-18a Hepatoblastoma 24570391 MicroRNA expression might predict prognosis of epithelial hepatoblastoma. -tissue_expression_ns hsa-mir-195 Hepatoblastoma 24570391 MicroRNA expression might predict prognosis of epithelial hepatoblastoma. -tissue_expression_ns hsa-mir-210 Hepatoblastoma 24570391 MicroRNA expression might predict prognosis of epithelial hepatoblastoma. -tissue_expression_ns hsa-mir-214 Hepatoblastoma 24570391 MicroRNA expression might predict prognosis of epithelial hepatoblastoma. -tissue_expression_ns hsa-mir-221 Hepatoblastoma 24570391 MicroRNA expression might predict prognosis of epithelial hepatoblastoma. -tissue_expression_ns hsa-mir-222 Hepatoblastoma 24570391 MicroRNA expression might predict prognosis of epithelial hepatoblastoma. -tissue_expression_ns hsa-mir-223 Hepatoblastoma 24570391 MicroRNA expression might predict prognosis of epithelial hepatoblastoma. -tissue_expression_ns hsa-mir-224 Hepatoblastoma 24570391 MicroRNA expression might predict prognosis of epithelial hepatoblastoma. -tissue_expression_ns hsa-mir-34a Hepatoblastoma 24570391 MicroRNA expression might predict prognosis of epithelial hepatoblastoma. -tissue_expression_ns hsa-mir-96 Hepatoblastoma 24570391 MicroRNA expression might predict prognosis of epithelial hepatoblastoma. -tissue_expression_ns hsa-mir-155 Lung Neoplasms 24574164 "Under clinical conditions, mRNA detection is likely unsuitable for improving sensitivity of EBUS-TBNA-facilitated cancer staging. In contrast,detection of miRNA combined with EBUS-TBNA cytology may improve staging sensitivity." -tissue_expression_ns hsa-mir-200c Lung Neoplasms 24574164 "Under clinical conditions, mRNA detection is likely unsuitable for improving sensitivity of EBUS-TBNA-facilitated cancer staging. In contrast,detection of miRNA combined with EBUS-TBNA cytology may improve staging sensitivity." -tissue_expression_ns hsa-mir-21 Lung Neoplasms 24574164 "Under clinical conditions, mRNA detection is likely unsuitable for improving sensitivity of EBUS-TBNA-facilitated cancer staging. In contrast,detection of miRNA combined with EBUS-TBNA cytology may improve staging sensitivity." -tissue_expression_ns hsa-mir-34a Lung Neoplasms 24574164 "Under clinical conditions, mRNA detection is likely unsuitable for improving sensitivity of EBUS-TBNA-facilitated cancer staging. In contrast,detection of miRNA combined with EBUS-TBNA cytology may improve staging sensitivity." -tissue_expression_ns hsa-mir-100 "Adenocarcinoma, Pancreatic Ductal" 24575833 A microRNA meta-signature for pancreatic ductal adenocarcinoma. -tissue_expression_ns hsa-mir-143 "Adenocarcinoma, Pancreatic Ductal" 24575833 A microRNA meta-signature for pancreatic ductal adenocarcinoma. -tissue_expression_ns hsa-mir-148a "Adenocarcinoma, Pancreatic Ductal" 24575833 A microRNA meta-signature for pancreatic ductal adenocarcinoma. -tissue_expression_ns hsa-mir-155 "Adenocarcinoma, Pancreatic Ductal" 24575833 A microRNA meta-signature for pancreatic ductal adenocarcinoma. -tissue_expression_ns hsa-mir-21 "Adenocarcinoma, Pancreatic Ductal" 24575833 A microRNA meta-signature for pancreatic ductal adenocarcinoma. -tissue_expression_ns hsa-mir-217 "Adenocarcinoma, Pancreatic Ductal" 24575833 A microRNA meta-signature for pancreatic ductal adenocarcinoma. -tissue_expression_ns hsa-mir-221 "Adenocarcinoma, Pancreatic Ductal" 24575833 A microRNA meta-signature for pancreatic ductal adenocarcinoma. -tissue_expression_ns hsa-mir-23a "Adenocarcinoma, Pancreatic Ductal" 24575833 A microRNA meta-signature for pancreatic ductal adenocarcinoma. -tissue_expression_ns hsa-mir-31 "Adenocarcinoma, Pancreatic Ductal" 24575833 A microRNA meta-signature for pancreatic ductal adenocarcinoma. -tissue_expression_ns hsa-mir-375 "Adenocarcinoma, Pancreatic Ductal" 24575833 A microRNA meta-signature for pancreatic ductal adenocarcinoma. -tissue_expression_ns hsa-mir-103 Early-Stage Gastric Carcinoma 24577775 Abnormal mirna expression level in early gastric cancer tissues may be associated to the development of gastric cancer. -tissue_expression_ns hsa-mir-141 Early-Stage Gastric Carcinoma 24577775 Abnormal mirna expression level in early gastric cancer tissues may be associated to the development of gastric cancer. -tissue_expression_ns hsa-mir-142 Early-Stage Gastric Carcinoma 24577775 Abnormal mirna expression level in early gastric cancer tissues may be associated to the development of gastric cancer. -tissue_expression_ns hsa-mir-196a Early-Stage Gastric Carcinoma 24577775 Abnormal mirna expression level in early gastric cancer tissues may be associated to the development of gastric cancer. -tissue_expression_ns hsa-mir-25 Early-Stage Gastric Carcinoma 24577775 Abnormal mirna expression level in early gastric cancer tissues may be associated to the development of gastric cancer. -tissue_expression_ns hsa-mir-9-1 Early-Stage Gastric Carcinoma 24577775 Abnormal mirna expression level in early gastric cancer tissues may be associated to the development of gastric cancer. -tissue_expression_ns hsa-mir-196b Tuberculosis 24586438 "The microRNA differential-expression profiles generated in this study provide a good foundation for the development of markers for TB diagnosis, and for investigations on the role of microRNAs in BCG-inoculated and latent-infected individuals." -tissue_expression_ns hsa-mir-376c Tuberculosis 24586438 "The microRNA differential-expression profiles generated in this study provide a good foundation for the development of markers for TB diagnosis, and for investigations on the role of microRNAs in BCG-inoculated and latent-infected individuals." -tissue_expression_ns hsa-mir-106a Ovarian Neoplasms 24591819 Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells. -tissue_expression_ns hsa-mir-107 Ovarian Neoplasms 24591819 Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells. -tissue_expression_ns hsa-mir-141 Ovarian Neoplasms 24591819 Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells. -tissue_expression_ns hsa-mir-187 Ovarian Neoplasms 24591819 Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells. -tissue_expression_ns hsa-mir-195 Ovarian Neoplasms 24591819 Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells. -tissue_expression_ns hsa-mir-200c Ovarian Neoplasms 24591819 Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells. -tissue_expression_ns hsa-mir-378 Ovarian Neoplasms 24591819 Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells. -tissue_expression_ns hsa-mir-409 Ovarian Neoplasms 24591819 Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells. -tissue_expression_ns hsa-mir-411 Ovarian Neoplasms 24591819 Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells. -tissue_expression_ns hsa-mir-432 Ovarian Neoplasms 24591819 Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells. -tissue_expression_ns hsa-mir-494 Ovarian Neoplasms 24591819 Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells. -tissue_expression_ns hsa-mir-497 Ovarian Neoplasms 24591819 Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells. -tissue_expression_ns hsa-mir-622 Ovarian Neoplasms 24591819 Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells. -tissue_expression_ns hsa-mir-647 Ovarian Neoplasms 24591819 Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells. -tissue_expression_ns hsa-mir-663 Ovarian Neoplasms 24591819 Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells. -tissue_expression_ns hsa-mir-96 Ovarian Neoplasms 24591819 Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells. -tissue_expression_ns hsa-mir-432 "Carcinoma, Hepatocellular" 24592541 Our study firstly demonstrated that miRNAs were differentially expressed in HCC-MVs compared with CHB and normal controls. Aberrant HCC-MVs miRNAs may play important roles in the development of HCC. -tissue_expression_ns hsa-mir-671 "Carcinoma, Hepatocellular" 24592541 Our study firstly demonstrated that miRNAs were differentially expressed in HCC-MVs compared with CHB and normal controls. Aberrant HCC-MVs miRNAs may play important roles in the development of HCC. -tissue_expression_ns hsa-mir-182 "Squamous Cell Carcinoma, Lung" 24600991 We provide first time evidence through tissue microarray and quantitative PCR validation of mir-182 in the expression of lung squamous cell carcinoma. Our data provide a possible mechanism for lung cancer cell proliferation in lung squamous cell cancer and may be helpful in discovering a new strategy to reveal lung squamous cell carcinoma progress. -tissue_expression_ns hsa-mir-222 "Diabetes Mellitus, Gestational" 24601884 Differential expression of microRNAs in omental adipose tissue from gestational diabetes mellitus subjects reveals miR-222 as a regulator of ER¦Á expression in estrogen-induced insulin resistance. -tissue_expression_ns hsa-mir-25 "Adenocarcinoma, Lung" 24606441 Tissue miR-25 expression may be associated with tumor progression and have prognostic implications in female lung ADC patients. -tissue_expression_ns hsa-mir-202 Endometriosis 24608518 "Differences in miRNA levels could modulate the expression of VEGF-A and TSP-1, which may play an important role in the pathogenesis of endometriosis. The higher angiogenic and proteolytic activities observed in eutopic endometrium from patients might facilitate the implantation of endometrial cells at ectopic sites." -tissue_expression_ns hsa-mir-424 Endometriosis 24608518 "Differences in miRNA levels could modulate the expression of VEGF-A and TSP-1, which may play an important role in the pathogenesis of endometriosis. The higher angiogenic and proteolytic activities observed in eutopic endometrium from patients might facilitate the implantation of endometrial cells at ectopic sites." -tissue_expression_ns hsa-mir-449b Endometriosis 24608518 "Differences in miRNA levels could modulate the expression of VEGF-A and TSP-1, which may play an important role in the pathogenesis of endometriosis. The higher angiogenic and proteolytic activities observed in eutopic endometrium from patients might facilitate the implantation of endometrial cells at ectopic sites." -tissue_expression_ns hsa-mir-556 Endometriosis 24608518 "Differences in miRNA levels could modulate the expression of VEGF-A and TSP-1, which may play an important role in the pathogenesis of endometriosis. The higher angiogenic and proteolytic activities observed in eutopic endometrium from patients might facilitate the implantation of endometrial cells at ectopic sites." -tissue_expression_ns hsa-mir-145 Neoplasms [unspecific] 24609385 "Together, our probabilistic approach of integrating expression and sequence scores establishes a functional link between the aberrant miRNA and mRNA expression, which was previously under-appreciated due to the methodological differences." -tissue_expression_ns hsa-mir-155 Neoplasms [unspecific] 24609385 "Together, our probabilistic approach of integrating expression and sequence scores establishes a functional link between the aberrant miRNA and mRNA expression, which was previously under-appreciated due to the methodological differences." -tissue_expression_ns hsa-mir-183 Neoplasms [unspecific] 24609385 "Together, our probabilistic approach of integrating expression and sequence scores establishes a functional link between the aberrant miRNA and mRNA expression, which was previously under-appreciated due to the methodological differences." -tissue_expression_ns hsa-mir-21 Neoplasms [unspecific] 24609385 "Together, our probabilistic approach of integrating expression and sequence scores establishes a functional link between the aberrant miRNA and mRNA expression, which was previously under-appreciated due to the methodological differences." -tissue_expression_ns hsa-mir-221 Neoplasms [unspecific] 24609385 "Together, our probabilistic approach of integrating expression and sequence scores establishes a functional link between the aberrant miRNA and mRNA expression, which was previously under-appreciated due to the methodological differences." -tissue_expression_ns hsa-mir-222 Neoplasms [unspecific] 24609385 "Together, our probabilistic approach of integrating expression and sequence scores establishes a functional link between the aberrant miRNA and mRNA expression, which was previously under-appreciated due to the methodological differences." -tissue_expression_ns hsa-mir-122 Hepatitis C Virus Infection 24612050 "However, a significant difference was observed in miR-122 expression between patients who showed a sustained virological response (SVR) and those who did not (Pâ€?â€?.05)." -tissue_expression_ns hsa-mir-132 Gastric Neoplasms 24621117 miR-132 could serve as an efficient prognostic factor for gastric cancer patients. -tissue_expression_ns hsa-mir-489 "Carcinoma, Renal Cell" 24621579 New miRNA profiles accurately distinguish renal cell carcinomas and upper tract urothelial carcinomas from the normal kidney. -tissue_expression_ns hsa-mir-17 Breast Neoplasms 24626680 MicroRNA expression profiles in human breast cancer cells after multifraction and single-dose radiation treatment. -tissue_expression_ns hsa-mir-18a Breast Neoplasms 24626680 MicroRNA expression profiles in human breast cancer cells after multifraction and single-dose radiation treatment. -tissue_expression_ns hsa-mir-19a Breast Neoplasms 24626680 MicroRNA expression profiles in human breast cancer cells after multifraction and single-dose radiation treatment. -tissue_expression_ns hsa-mir-19b Breast Neoplasms 24626680 MicroRNA expression profiles in human breast cancer cells after multifraction and single-dose radiation treatment. -tissue_expression_ns hsa-mir-20a Breast Neoplasms 24626680 MicroRNA expression profiles in human breast cancer cells after multifraction and single-dose radiation treatment. -tissue_expression_ns hsa-mir-92a Breast Neoplasms 24626680 MicroRNA expression profiles in human breast cancer cells after multifraction and single-dose radiation treatment. -tissue_expression_ns hsa-mir-146b "Carcinoma, Thyroid, Follicular" 24631480 Differential miRNA expression defines migration and reduced apoptosis in follicular thyroid carcinomas. -tissue_expression_ns hsa-mir-183 "Carcinoma, Thyroid, Follicular" 24631480 Differential miRNA expression defines migration and reduced apoptosis in follicular thyroid carcinomas. -tissue_expression_ns hsa-mir-199b "Carcinoma, Thyroid, Follicular" 24631480 Differential miRNA expression defines migration and reduced apoptosis in follicular thyroid carcinomas. -tissue_expression_ns hsa-mir-221 "Carcinoma, Thyroid, Follicular" 24631480 Differential miRNA expression defines migration and reduced apoptosis in follicular thyroid carcinomas. -tissue_expression_ns hsa-mir-155 "Carcinoma, Breast, Triple Negative" 24632568 microRNA expression profiling identifies a four microRNA signature as a novel diagnostic and prognostic biomarker in triple negative breast cancers. -tissue_expression_ns hsa-mir-27a "Carcinoma, Breast, Triple Negative" 24632568 microRNA expression profiling identifies a four microRNA signature as a novel diagnostic and prognostic biomarker in triple negative breast cancers. -tissue_expression_ns hsa-mir-30e "Carcinoma, Breast, Triple Negative" 24632568 microRNA expression profiling identifies a four microRNA signature as a novel diagnostic and prognostic biomarker in triple negative breast cancers. -tissue_expression_ns hsa-mir-493 "Carcinoma, Breast, Triple Negative" 24632568 microRNA expression profiling identifies a four microRNA signature as a novel diagnostic and prognostic biomarker in triple negative breast cancers. -tissue_expression_ns hsa-mir-10a Breast Neoplasms 24632820 "In summary, we have identified a set of recurrence-related microRNAs with potential prognostic value to identify patients who will likely develop metastasis early after primary breast surgery." -tissue_expression_ns hsa-mir-149 Breast Neoplasms 24632820 "In summary, we have identified a set of recurrence-related microRNAs with potential prognostic value to identify patients who will likely develop metastasis early after primary breast surgery." -tissue_expression_ns hsa-mir-20b Breast Neoplasms 24632820 "In summary, we have identified a set of recurrence-related microRNAs with potential prognostic value to identify patients who will likely develop metastasis early after primary breast surgery." -tissue_expression_ns hsa-mir-30a Breast Neoplasms 24632820 "In summary, we have identified a set of recurrence-related microRNAs with potential prognostic value to identify patients who will likely develop metastasis early after primary breast surgery." -tissue_expression_ns hsa-mir-342 Breast Neoplasms 24632820 "In summary, we have identified a set of recurrence-related microRNAs with potential prognostic value to identify patients who will likely develop metastasis early after primary breast surgery." -tissue_expression_ns hsa-mir-125b Hepatitis C Virus Infection 24637254 "PBMC-miR-125b expression levels were inversely related to the achievement of an SVR in HCV-1 patients, independent of interleukin-28B genotype,and was the single predictor of SVR in non-RVR patients." -tissue_expression_ns hsa-mir-124 "Stroke, Hemorrhagic" 24650689 Both miR-124-3p and miR-16 are diagnostic markers to discriminate HS and IS. -tissue_expression_ns hsa-mir-16 "Stroke, Hemorrhagic" 24650689 Both miR-124-3p and miR-16 are diagnostic markers to discriminate HS and IS. -tissue_expression_ns hsa-mir-23a "Lymphoma, Large B-Cell, Diffuse" 24659264 MicroRNA-23a expression in paraffin-embedded specimen correlates with overall survival of diffuse large B-cell lymphoma. -tissue_expression_ns hsa-mir-130b Pancreatic Neoplasms 24662333 "We developed and validated a 5-miRNA classifier that can accurately predict which preoperative pancreatic EUS-FNA specimens contain PDAC. This test might aid in the diagnosis of pancreatic cancer by reducing the number of FNAs without a definitive adenocarcinoma diagnosis, thereby reducing the number of repeat EUS-FNA procedures." -tissue_expression_ns hsa-mir-135b Pancreatic Neoplasms 24662333 "We developed and validated a 5-miRNA classifier that can accurately predict which preoperative pancreatic EUS-FNA specimens contain PDAC. This test might aid in the diagnosis of pancreatic cancer by reducing the number of FNAs without a definitive adenocarcinoma diagnosis, thereby reducing the number of repeat EUS-FNA procedures." -tissue_expression_ns hsa-mir-148a Pancreatic Neoplasms 24662333 "We developed and validated a 5-miRNA classifier that can accurately predict which preoperative pancreatic EUS-FNA specimens contain PDAC. This test might aid in the diagnosis of pancreatic cancer by reducing the number of FNAs without a definitive adenocarcinoma diagnosis, thereby reducing the number of repeat EUS-FNA procedures." -tissue_expression_ns hsa-mir-196 Pancreatic Neoplasms 24662333 "We developed and validated a 5-miRNA classifier that can accurately predict which preoperative pancreatic EUS-FNA specimens contain PDAC. This test might aid in the diagnosis of pancreatic cancer by reducing the number of FNAs without a definitive adenocarcinoma diagnosis, thereby reducing the number of repeat EUS-FNA procedures." -tissue_expression_ns hsa-mir-24 Pancreatic Neoplasms 24662333 "We developed and validated a 5-miRNA classifier that can accurately predict which preoperative pancreatic EUS-FNA specimens contain PDAC. This test might aid in the diagnosis of pancreatic cancer by reducing the number of FNAs without a definitive adenocarcinoma diagnosis, thereby reducing the number of repeat EUS-FNA procedures." -tissue_expression_ns hsa-mir-125a Obesity 24675842 Adaptive expression of microRNA-125a in adipose tissue in response to obesity in mice and men. -tissue_expression_ns hsa-mir-19a "Carcinoma, Supraglottic" 24676647 MicroRNA expression profiles in supraglottic carcinoma. -tissue_expression_ns hsa-mir-206 "Carcinoma, Supraglottic" 24676647 MicroRNA expression profiles in supraglottic carcinoma. -tissue_expression_ns hsa-mir-21 "Carcinoma, Supraglottic" 24676647 MicroRNA expression profiles in supraglottic carcinoma. -tissue_expression_ns hsa-mir-33a "Carcinoma, Supraglottic" 24676647 MicroRNA expression profiles in supraglottic carcinoma. -tissue_expression_ns hsa-mir-375 "Carcinoma, Supraglottic" 24676647 MicroRNA expression profiles in supraglottic carcinoma. -tissue_expression_ns hsa-mir-30a "Carcinoma, Ovarian, Serous" 24676806 The expression of miR-30a* and miR-30e* is associated with a dualistic model for grading ovarian papillary serious carcinoma. -tissue_expression_ns hsa-mir-30e "Carcinoma, Ovarian, Serous" 24676806 The expression of miR-30a* and miR-30e* is associated with a dualistic model for grading ovarian papillary serious carcinoma. -tissue_expression_ns hsa-mir-21 "Carcinoma, Esophageal" 24680681 The expression of miR-21 and miR-375 predict prognosis of esophageal cancer. -tissue_expression_ns hsa-mir-375 "Carcinoma, Esophageal" 24680681 The expression of miR-21 and miR-375 predict prognosis of esophageal cancer. -tissue_expression_ns hsa-mir-125b-2 Recurrent Spontaneous Abortion 24686457 Genome-wide miRNA profiling of villus and decidua of recurrent spontaneous abortion patients. -tissue_expression_ns hsa-mir-184 Recurrent Spontaneous Abortion 24686457 Genome-wide miRNA profiling of villus and decidua of recurrent spontaneous abortion patients. -tissue_expression_ns hsa-mir-187 Recurrent Spontaneous Abortion 24686457 Genome-wide miRNA profiling of villus and decidua of recurrent spontaneous abortion patients. -tissue_expression_ns hsa-mir-3175 Recurrent Spontaneous Abortion 24686457 Genome-wide miRNA profiling of villus and decidua of recurrent spontaneous abortion patients. -tissue_expression_ns hsa-mir-4672 Recurrent Spontaneous Abortion 24686457 Genome-wide miRNA profiling of villus and decidua of recurrent spontaneous abortion patients. -tissue_expression_ns hsa-mir-517c Recurrent Spontaneous Abortion 24686457 Genome-wide miRNA profiling of villus and decidua of recurrent spontaneous abortion patients. -tissue_expression_ns hsa-mir-519a-1 Recurrent Spontaneous Abortion 24686457 Genome-wide miRNA profiling of villus and decidua of recurrent spontaneous abortion patients. -tissue_expression_ns hsa-mir-520f Recurrent Spontaneous Abortion 24686457 Genome-wide miRNA profiling of villus and decidua of recurrent spontaneous abortion patients. -tissue_expression_ns hsa-mir-520h Recurrent Spontaneous Abortion 24686457 Genome-wide miRNA profiling of villus and decidua of recurrent spontaneous abortion patients. -tissue_expression_ns hsa-mir-522 Recurrent Spontaneous Abortion 24686457 Genome-wide miRNA profiling of villus and decidua of recurrent spontaneous abortion patients. -tissue_expression_ns hsa-let-7d Glioblastoma 24691539 microRNA expression pattern modulates temozolomide response in GBM tumors with cancer stem cells. -tissue_expression_ns hsa-mir-10a Glioblastoma 24691539 microRNA expression pattern modulates temozolomide response in GBM tumors with cancer stem cells. -tissue_expression_ns hsa-mir-10b Glioblastoma 24691539 microRNA expression pattern modulates temozolomide response in GBM tumors with cancer stem cells. -tissue_expression_ns hsa-mir-137 Glioblastoma 24691539 microRNA expression pattern modulates temozolomide response in GBM tumors with cancer stem cells. -tissue_expression_ns hsa-mir-145 Glioblastoma 24691539 microRNA expression pattern modulates temozolomide response in GBM tumors with cancer stem cells. -tissue_expression_ns hsa-mir-153 Glioblastoma 24691539 microRNA expression pattern modulates temozolomide response in GBM tumors with cancer stem cells. -tissue_expression_ns hsa-mir-181b Glioblastoma 24691539 microRNA expression pattern modulates temozolomide response in GBM tumors with cancer stem cells. -tissue_expression_ns hsa-mir-455 Glioblastoma 24691539 microRNA expression pattern modulates temozolomide response in GBM tumors with cancer stem cells. -tissue_expression_ns hsa-mir-9 Glioblastoma 24691539 microRNA expression pattern modulates temozolomide response in GBM tumors with cancer stem cells. -tissue_expression_ns hsa-mir-122 Hepatitis C Virus Infection 24696531 The study thus unveiled the role of miR-122 as a plausible diagnostic biomarker during HCV genotype-3 infection in India. -tissue_expression_ns hsa-mir-215 "Carcinoma, Cervical" 24710934 "It was concluded that the expression level of miR-215 is associated with cervical tumor progression and worse survival rate, suggesting that it may serve as a potential prognostic marker to identify patients at higher risk of recurrence." -tissue_expression_ns hsa-mir-210 Astrocytoma 24729345 "MiR-210 levels can be potentially established as a biomarker for pathological diagnosis of malignant astrocytic tumour progression. In addition,the expression of miR-210 can be utilized as an additional identification measure of glioma tumour origin." -tissue_expression_ns hsa-mir-138 Colon Neoplasms 24732966 "miRs including mir-425, mir-196, mir-155, mir-150, mir-351, mir-16, let-7, mir34, and mir-138 were differentially expressed between the dietary groups." -tissue_expression_ns hsa-mir-21 Uterine Corpus Serous Adenocarcinoma 24748979 microRNA expression patterns across seven cancers are highly correlated and dominated by evolutionarily ancient families. -tissue_expression_ns hsa-mir-21 "Squamous Cell Carcinoma, Oral" 24755828 MiR-21 expression in the tumor stroma of oral squamous cell carcinoma: an independent biomarker of disease free survival. -tissue_expression_ns hsa-mir-200a Obesity 24758184 "Taken together, our data indicate that the dysregulated expression of miRNAs occurs in distinct cell types and is likely to affect cell-specific function(s) of obese WAT." -tissue_expression_ns hsa-mir-200b Obesity 24758184 "Taken together, our data indicate that the dysregulated expression of miRNAs occurs in distinct cell types and is likely to affect cell-specific function(s) of obese WAT." -tissue_expression_ns hsa-mir-335 Obesity 24758184 "Taken together, our data indicate that the dysregulated expression of miRNAs occurs in distinct cell types and is likely to affect cell-specific function(s) of obese WAT." -tissue_expression_ns hsa-mir-342 Obesity 24758184 "Taken together, our data indicate that the dysregulated expression of miRNAs occurs in distinct cell types and is likely to affect cell-specific function(s) of obese WAT." -tissue_expression_ns hsa-mir-122 Varicella 24759212 Dysregulated microRNA expression in serum of non-vaccinated children with varicella. -tissue_expression_ns hsa-mir-132 Varicella 24759212 Dysregulated microRNA expression in serum of non-vaccinated children with varicella. -tissue_expression_ns hsa-mir-197 Varicella 24759212 Dysregulated microRNA expression in serum of non-vaccinated children with varicella. -tissue_expression_ns hsa-mir-363 Varicella 24759212 Dysregulated microRNA expression in serum of non-vaccinated children with varicella. -tissue_expression_ns hsa-mir-629 Varicella 24759212 Dysregulated microRNA expression in serum of non-vaccinated children with varicella. -tissue_expression_ns hsa-mir-125a Post-Traumatic Stress Disorder 24759737 Dysregulation in microRNA expression is associated with alterations in immune functions in combat veterans with post-traumatic stress disorder. -tissue_expression_ns hsa-mir-199a Keloid 24782087 Keloid microRNA expression analysis and the influence of miR-199a-5p on the proliferation of keloid fibroblasts. -tissue_expression_ns hsa-mir-21 Perlman Syndrome 24786382 Our study is the first to investigate the association between placental miRNA expression and macrosomia. Our results indicate that the expression level of miR-21 in placental tissue may be involved in the development of macrosomia. -tissue_expression_ns hsa-mir-145 "Adenocarcinoma, Colon" 24791633 "Differential expression of microRNA-320a, -145, and-192 along the continuum of normal mucosa to high-grade dysplastic adenomas of the colorectum." -tissue_expression_ns hsa-mir-192 "Adenocarcinoma, Colon" 24791633 "Differential expression of microRNA-320a, -145, and-193 along the continuum of normal mucosa to high-grade dysplastic adenomas of the colorectum." -tissue_expression_ns hsa-mir-320a "Adenocarcinoma, Colon" 24791633 "Differential expression of microRNA-320a, -145, and-194 along the continuum of normal mucosa to high-grade dysplastic adenomas of the colorectum." -tissue_expression_ns hsa-mir-26a Multiple Sclerosis 24792898 "miR-326 and miR-26a, two potential markers for diagnosis of relapse and remission phases in patient with relapsing-remitting multiple sclerosis." -tissue_expression_ns hsa-mir-326 Multiple Sclerosis 24792898 "miR-326 and miR-26a, two potential markers for diagnosis of relapse and remission phases in patient with relapsing-remitting multiple sclerosis." -tissue_expression_ns hsa-mir-148a "Carcinoma, Hepatocellular" 24798342 microRNA-148a dysregulation discriminates poor prognosis of hepatocellular carcinoma in association with USP4 overexpression. -tissue_expression_ns hsa-let-7a "Carcinoma, Lung, Non-Small-Cell" 24802132 "Before PRFA, tumor suppressor let-7a and miR-34a were downregulated whereas oncomiR miR-21 was upregulated in primary tumors, and let-7a and miR-126 levels were downregulated whereas oncomiRs miR-21, miR-155 and miR-17-5p/miR-20b levels were upregulated in secondary tumors." -tissue_expression_ns hsa-mir-214 "Carcinoma, Hepatocellular" 24804874 "Among the analysed miRNAs, high miR-214 expression was associated with smaller tumor size (p=0.019), whereas high miR-17-5p expression correlated with better Eastern Cooperative Oncology Group performance status (p=0.003)." -tissue_expression_ns hsa-mir-106b Ovarian Neoplasms 24805828 "The results obtained by miRNA microarrays of differential expression with hsa-miR-106b-3p, hsa-miR-152, hsa-miR-200a-3p, hsa-miR-381, and hsa-miR-429 were confirmed by real-time PCR." -tissue_expression_ns hsa-mir-17 "Carcinoma, Breast, Triple Negative" 24810926 "Triple-negative and luminal A breast tumors: differential expression of miR-18a-5p, miR-17-5p, and miR-20a-5p." -tissue_expression_ns hsa-mir-18a "Carcinoma, Breast, Triple Negative" 24810926 "Triple-negative and luminal A breast tumors: differential expression of miR-18a-5p, miR-17-5p, and miR-20a-5p." -tissue_expression_ns hsa-mir-20a "Carcinoma, Breast, Triple Negative" 24810926 "Triple-negative and luminal A breast tumors: differential expression of miR-18a-5p, miR-17-5p, and miR-20a-5p." -tissue_expression_ns hsa-mir-1271 "Carcinoma, Ovarian" 24816756 A ten-microRNA signature identified from a genome-wide microRNA expression profiling in human epithelial ovarian cancer. -tissue_expression_ns hsa-mir-130b "Carcinoma, Ovarian" 24816756 A ten-microRNA signature identified from a genome-wide microRNA expression profiling in human epithelial ovarian cancer. -tissue_expression_ns hsa-mir-135b "Carcinoma, Ovarian" 24816756 A ten-microRNA signature identified from a genome-wide microRNA expression profiling in human epithelial ovarian cancer. -tissue_expression_ns hsa-mir-141 "Carcinoma, Ovarian" 24816756 A ten-microRNA signature identified from a genome-wide microRNA expression profiling in human epithelial ovarian cancer. -tissue_expression_ns hsa-mir-15b "Carcinoma, Ovarian" 24816756 A ten-microRNA signature identified from a genome-wide microRNA expression profiling in human epithelial ovarian cancer. -tissue_expression_ns hsa-mir-182 "Carcinoma, Ovarian" 24816756 A ten-microRNA signature identified from a genome-wide microRNA expression profiling in human epithelial ovarian cancer. -tissue_expression_ns hsa-mir-183 "Carcinoma, Ovarian" 24816756 A ten-microRNA signature identified from a genome-wide microRNA expression profiling in human epithelial ovarian cancer. -tissue_expression_ns hsa-mir-574 "Carcinoma, Ovarian" 24816756 A ten-microRNA signature identified from a genome-wide microRNA expression profiling in human epithelial ovarian cancer. -tissue_expression_ns hsa-mir-96 "Carcinoma, Ovarian" 24816756 A ten-microRNA signature identified from a genome-wide microRNA expression profiling in human epithelial ovarian cancer. -tissue_expression_ns hsa-mir-106a Atrial Fibrillation 24824214 Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation. -tissue_expression_ns hsa-mir-106b Atrial Fibrillation 24824214 Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation. -tissue_expression_ns hsa-mir-144 Atrial Fibrillation 24824214 Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation. -tissue_expression_ns hsa-mir-15b Atrial Fibrillation 24824214 Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation. -tissue_expression_ns hsa-mir-19 Atrial Fibrillation 24824214 Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation. -tissue_expression_ns hsa-mir-208a Atrial Fibrillation 24824214 Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation. -tissue_expression_ns hsa-mir-23a Atrial Fibrillation 24824214 Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation. -tissue_expression_ns hsa-mir-25 Atrial Fibrillation 24824214 Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation. -tissue_expression_ns hsa-mir-30a Atrial Fibrillation 24824214 Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation. -tissue_expression_ns hsa-mir-363 Atrial Fibrillation 24824214 Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation. -tissue_expression_ns hsa-mir-451 Atrial Fibrillation 24824214 Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation. -tissue_expression_ns hsa-mir-486 Atrial Fibrillation 24824214 Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation. -tissue_expression_ns hsa-mir-590 Atrial Fibrillation 24824214 Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation. -tissue_expression_ns hsa-mir-93 Atrial Fibrillation 24824214 Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation. -tissue_expression_ns hsa-mir-338 Colorectal Carcinoma 24824250 Relationship between miRNA-338-3p expression and progression and prognosis of human colorectal carcinoma. -tissue_expression_ns hsa-mir-155 Neoplasms [unspecific] 24824925 miR-155 as a diagnostic and prognostic marker in hematological and solid malignancies -tissue_expression_ns hsa-mir-370 "Adenocarcinoma, Lung" 24833665 "Different morphologic subtypes of lung AC have distinct miRNA expression profiles, and 3 miRNAs encoded at 14q32 (miR-411, miR-370, and miR-376a) were associated with poor survival after lung AC resection." -tissue_expression_ns hsa-mir-376a "Adenocarcinoma, Lung" 24833665 "Different morphologic subtypes of lung AC have distinct miRNA expression profiles, and 3 miRNAs encoded at 14q32 (miR-411, miR-370, and miR-376a) were associated with poor survival after lung AC resection." -tissue_expression_ns hsa-mir-411 "Adenocarcinoma, Lung" 24833665 "Different morphologic subtypes of lung AC have distinct miRNA expression profiles, and 3 miRNAs encoded at 14q32 (miR-411, miR-370, and miR-376a) were associated with poor survival after lung AC resection." -tissue_expression_ns hsa-mir-146a Pancreatic Neoplasms 24839931 Deregulation of miR-146a expression in a mouse model of pancreatic cancer affecting EGFR signaling. -tissue_expression_ns hsa-mir-142 Breast Neoplasms 24846313 miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features. -tissue_expression_ns hsa-mir-185 Breast Neoplasms 24846313 miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features. -tissue_expression_ns hsa-mir-191 Breast Neoplasms 24846313 miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features. -tissue_expression_ns hsa-mir-200a Breast Neoplasms 24846313 miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features. -tissue_expression_ns hsa-mir-200b Breast Neoplasms 24846313 miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features. -tissue_expression_ns hsa-mir-206 Breast Neoplasms 24846313 miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features. -tissue_expression_ns hsa-mir-29b Breast Neoplasms 24846313 miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features. -tissue_expression_ns hsa-mir-30c Breast Neoplasms 24846313 miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features. -tissue_expression_ns hsa-mir-3196 Breast Neoplasms 24846313 miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features. -tissue_expression_ns hsa-mir-339 Breast Neoplasms 24846313 miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features. -tissue_expression_ns hsa-mir-3923 Breast Neoplasms 24846313 miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features. -tissue_expression_ns hsa-mir-421 Breast Neoplasms 24846313 miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features. -tissue_expression_ns hsa-mir-451 Breast Neoplasms 24846313 miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features. -tissue_expression_ns hsa-mir-542 Breast Neoplasms 24846313 miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features. -tissue_expression_ns hsa-mir-564 Breast Neoplasms 24846313 miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features. -tissue_expression_ns hsa-mir-92a Breast Neoplasms 24846313 miRNA expression in breast cancer varies with lymph node metastasis and other clinicopathologic features. -tissue_expression_ns hsa-mir-21 Lung Neoplasms 24880588 Diagnostic value of microRNA-21 in the diagnosis of lung cancer: evidence from a meta-analysis involving 11 studies. -tissue_expression_ns hsa-mir-324 "Carcinoma, Colon" 24882011 Dysregulation of the miR-324-5p-CUEDC2 axis leads to macrophage dysfunction and is associated with colon cancer. -tissue_expression_ns hsa-mir-195 "Carcinoma, Adrenocortical" 24890943 "In conclusion, (a) miR-483-3p, miR-483-5p, and miR-210 are differentially expressed in ACC variants, and (b) high miR-210 is associated with clinicopathologic parameters of aggressiveness and a poor prognosis." -tissue_expression_ns hsa-mir-1974 "Carcinoma, Adrenocortical" 24890943 "In conclusion, (a) miR-483-3p, miR-483-5p, and miR-210 are differentially expressed in ACC variants, and (b) high miR-210 is associated with clinicopathologic parameters of aggressiveness and a poor prognosis." -tissue_expression_ns hsa-mir-210 "Carcinoma, Adrenocortical" 24890943 "In conclusion, (a) miR-483-3p, miR-483-5p, and miR-210 are differentially expressed in ACC variants, and (b) high miR-210 is associated with clinicopathologic parameters of aggressiveness and a poor prognosis." -tissue_expression_ns hsa-mir-483 "Carcinoma, Adrenocortical" 24890943 "In conclusion, (a) miR-483-3p, miR-483-5p, and miR-210 are differentially expressed in ACC variants, and (b) high miR-210 is associated with clinicopathologic parameters of aggressiveness and a poor prognosis." -tissue_expression_ns hsa-mir-21 Muscle Atrophy 24891504 "Among the different miRNAs, microRNA-206 and -21 were the most induced in denervated muscles." -tissue_expression_ns hsa-mir-101-1 "Adenocarcinoma, Lung" 24893932 "We identified an eight-miRNA signature that is prognostic of LUAD.The miRNA signature, if validated in other prospective studies, may have important implications in clinical practice, in particular identifying a subgroup of patients with LUAD who are at high risk of mortality." -tissue_expression_ns hsa-mir-187 "Adenocarcinoma, Lung" 24893932 "We identified an eight-miRNA signature that is prognostic of LUAD.The miRNA signature, if validated in other prospective studies, may have important implications in clinical practice, in particular identifying a subgroup of patients with LUAD who are at high risk of mortality." -tissue_expression_ns hsa-mir-196b "Adenocarcinoma, Lung" 24893932 "We identified an eight-miRNA signature that is prognostic of LUAD.The miRNA signature, if validated in other prospective studies, may have important implications in clinical practice, in particular identifying a subgroup of patients with LUAD who are at high risk of mortality." -tissue_expression_ns hsa-mir-31 "Adenocarcinoma, Lung" 24893932 "We identified an eight-miRNA signature that is prognostic of LUAD.The miRNA signature, if validated in other prospective studies, may have important implications in clinical practice, in particular identifying a subgroup of patients with LUAD who are at high risk of mortality." -tissue_expression_ns hsa-mir-331 "Adenocarcinoma, Lung" 24893932 "We identified an eight-miRNA signature that is prognostic of LUAD.The miRNA signature, if validated in other prospective studies, may have important implications in clinical practice, in particular identifying a subgroup of patients with LUAD who are at high risk of mortality." -tissue_expression_ns hsa-mir-375 "Adenocarcinoma, Lung" 24893932 "We identified an eight-miRNA signature that is prognostic of LUAD.The miRNA signature, if validated in other prospective studies, may have important implications in clinical practice, in particular identifying a subgroup of patients with LUAD who are at high risk of mortality." -tissue_expression_ns hsa-mir-519a-1 "Adenocarcinoma, Lung" 24893932 "We identified an eight-miRNA signature that is prognostic of LUAD.The miRNA signature, if validated in other prospective studies, may have important implications in clinical practice, in particular identifying a subgroup of patients with LUAD who are at high risk of mortality." -tissue_expression_ns hsa-mir-766 "Adenocarcinoma, Lung" 24893932 "We identified an eight-miRNA signature that is prognostic of LUAD.The miRNA signature, if validated in other prospective studies, may have important implications in clinical practice, in particular identifying a subgroup of patients with LUAD who are at high risk of mortality." -tissue_expression_ns hsa-mir-5000 "Carcinoma, Colon" 24898979 "MiR-5000-3p, miR-5009-3P and miR-552: potential microRNA biomarkers of side population cells in colon cancer." -tissue_expression_ns hsa-mir-5009 "Carcinoma, Colon" 24898979 "MiR-5000-3p, miR-5009-3P and miR-552: potential microRNA biomarkers of side population cells in colon cancer." -tissue_expression_ns hsa-mir-552 "Carcinoma, Colon" 24898979 "MiR-5000-3p, miR-5009-3P and miR-552: potential microRNA biomarkers of side population cells in colon cancer." -tissue_expression_ns hsa-mir-103 Gastric Neoplasms 24902858 This systematic review study of human GC microRNA expression profiling studies would provide information on microRNAs with potential role as the biomarkers in gastric cancer. -tissue_expression_ns hsa-mir-107 Gastric Neoplasms 24902858 This systematic review study of human GC microRNA expression profiling studies would provide information on microRNAs with potential role as the biomarkers in gastric cancer. -tissue_expression_ns hsa-mir-148a Gastric Neoplasms 24902858 This systematic review study of human GC microRNA expression profiling studies would provide information on microRNAs with potential role as the biomarkers in gastric cancer. -tissue_expression_ns hsa-mir-21 Gastric Neoplasms 24902858 This systematic review study of human GC microRNA expression profiling studies would provide information on microRNAs with potential role as the biomarkers in gastric cancer. -tissue_expression_ns hsa-mir-223 Gastric Neoplasms 24902858 This systematic review study of human GC microRNA expression profiling studies would provide information on microRNAs with potential role as the biomarkers in gastric cancer. -tissue_expression_ns hsa-mir-25 Gastric Neoplasms 24902858 This systematic review study of human GC microRNA expression profiling studies would provide information on microRNAs with potential role as the biomarkers in gastric cancer. -tissue_expression_ns hsa-mir-375 Gastric Neoplasms 24902858 This systematic review study of human GC microRNA expression profiling studies would provide information on microRNAs with potential role as the biomarkers in gastric cancer. -tissue_expression_ns hsa-mir-638 Gastric Neoplasms 24902858 This systematic review study of human GC microRNA expression profiling studies would provide information on microRNAs with potential role as the biomarkers in gastric cancer. -tissue_expression_ns hsa-mir-92 Gastric Neoplasms 24902858 This systematic review study of human GC microRNA expression profiling studies would provide information on microRNAs with potential role as the biomarkers in gastric cancer. -tissue_expression_ns hsa-mir-195 "Adenocarcinoma, Lung" 24903339 Lung adenocarcinoma subtypes definable by lung development-related miRNA expression profiles in association with clinicopathologic features. -tissue_expression_ns hsa-mir-30d "Adenocarcinoma, Lung" 24903339 Lung adenocarcinoma subtypes definable by lung development-related miRNA expression profiles in association with clinicopathologic features. -tissue_expression_ns hsa-mir-124 Crohn Disease 24910152 Both inflamed and non-inflamed terminal ileal mucosa in adult patients with active CD have their distinct miRNA expression patterns compared with healthy controls. Dysregulated miRNAs may be responsible for pathogenesis of CD. -tissue_expression_ns hsa-mir-192 Crohn Disease 24910152 Both inflamed and non-inflamed terminal ileal mucosa in adult patients with active CD have their distinct miRNA expression patterns compared with healthy controls. Dysregulated miRNAs may be responsible for pathogenesis of CD. -tissue_expression_ns hsa-mir-361 Crohn Disease 24910152 Both inflamed and non-inflamed terminal ileal mucosa in adult patients with active CD have their distinct miRNA expression patterns compared with healthy controls. Dysregulated miRNAs may be responsible for pathogenesis of CD. -tissue_expression_ns hsa-mir-495 Crohn Disease 24910152 Both inflamed and non-inflamed terminal ileal mucosa in adult patients with active CD have their distinct miRNA expression patterns compared with healthy controls. Dysregulated miRNAs may be responsible for pathogenesis of CD. -tissue_expression_ns hsa-mir-126 Pleural Mesothelioma 24912849 "Diagnostic potential of miR-126, miR-143, miR-145, and miR-652 in malignant pleural mesothelioma." -tissue_expression_ns hsa-mir-221 Acute Liver Failure 24913549 "In liver biopsies, miR-21 and miR-221 displayed a reciprocal expression pattern and were found at lower levels in the spontaneous survivors, whereas miR-122 was elevated in both serum and liver tissue of those patients." -tissue_expression_ns hsa-mir-1248 Breast Neoplasms 24917463 "we identified miRNA expression signatures predictive of BRCA1/2 mutation status in routinely available FFPE breast tumor samples, which may be useful to complement current patient selection criteria for gene testing by identifying individuals with high likelihood of being BRCA1/2 mutation carriers." -tissue_expression_ns hsa-mir-142 Breast Neoplasms 24917463 "we identified miRNA expression signatures predictive of BRCA1/2 mutation status in routinely available FFPE breast tumor samples, which may be useful to complement current patient selection criteria for gene testing by identifying individuals with high likelihood of being BRCA1/2 mutation carriers." -tissue_expression_ns hsa-mir-181a-2 Breast Neoplasms 24917463 "we identified miRNA expression signatures predictive of BRCA1/2 mutation status in routinely available FFPE breast tumor samples, which may be useful to complement current patient selection criteria for gene testing by identifying individuals with high likelihood of being BRCA1/2 mutation carriers." -tissue_expression_ns hsa-mir-25 Breast Neoplasms 24917463 "we identified miRNA expression signatures predictive of BRCA1/2 mutation status in routinely available FFPE breast tumor samples, which may be useful to complement current patient selection criteria for gene testing by identifying individuals with high likelihood of being BRCA1/2 mutation carriers." -tissue_expression_ns hsa-mir-340 Breast Neoplasms 24917463 "we identified miRNA expression signatures predictive of BRCA1/2 mutation status in routinely available FFPE breast tumor samples, which may be useful to complement current patient selection criteria for gene testing by identifying individuals with high likelihood of being BRCA1/2 mutation carriers." -tissue_expression_ns hsa-mir-505 Breast Neoplasms 24917463 "we identified miRNA expression signatures predictive of BRCA1/2 mutation status in routinely available FFPE breast tumor samples, which may be useful to complement current patient selection criteria for gene testing by identifying individuals with high likelihood of being BRCA1/2 mutation carriers." -tissue_expression_ns hsa-mir-205 Colorectal Carcinoma 24935592 Diagnostic and prognostic value of miR-205 in colorectal cancer. -tissue_expression_ns hsa-mir-138 Colon Neoplasms 24941171 This is the first to reveal the importance of aberrant expression of miRNAs in dynamically transformation from chronic colitis to colitis-associated cancer. These findings shed light on revealing the mechanisms of chronic colitis malignant transformation. -tissue_expression_ns hsa-mir-145 Colon Neoplasms 24941171 This is the first to reveal the importance of aberrant expression of miRNAs in dynamically transformation from chronic colitis to colitis-associated cancer. These findings shed light on revealing the mechanisms of chronic colitis malignant transformation. -tissue_expression_ns hsa-mir-146a Colon Neoplasms 24941171 This is the first to reveal the importance of aberrant expression of miRNAs in dynamically transformation from chronic colitis to colitis-associated cancer. These findings shed light on revealing the mechanisms of chronic colitis malignant transformation. -tissue_expression_ns hsa-mir-150 Colon Neoplasms 24941171 This is the first to reveal the importance of aberrant expression of miRNAs in dynamically transformation from chronic colitis to colitis-associated cancer. These findings shed light on revealing the mechanisms of chronic colitis malignant transformation. -tissue_expression_ns hsa-let-7e "Carcinoma, Lung, Non-Small-Cell" 24945821 Differential expression of miR-125a-5p and let-7e predicts the progression and prognosis of non-small cell lung cancer. -tissue_expression_ns hsa-mir-125a "Carcinoma, Lung, Non-Small-Cell" 24945821 Differential expression of miR-125a-5p and let-7e predicts the progression and prognosis of non-small cell lung cancer. -tissue_expression_ns hsa-mir-1 Prostate Neoplasms 24967583 miR-1 and miR-133b are differentially expressed in patients with recurrent prostate cancer. -tissue_expression_ns hsa-mir-133b Prostate Neoplasms 24967583 miR-1 and miR-133b are differentially expressed in patients with recurrent prostate cancer. -tissue_expression_ns hsa-mir-101 Hepatitis B Virus Infection 24971953 "Expression profiling of serum microRNA-101 in HBV-associated chronic hepatitis,liver cirrhosis, and hepatocellular carcinoma." -tissue_expression_ns hsa-mir-143 Neoplasms [unspecific] 24974841 Using microRNA expression profiles the authors were able to distinguish peritumoural tissues according to distance from the primary tumour site. Future application of the method may prove to be useful in early detection of the altered epigenetic regulation in tissue fields representing normal phenotype. This may be helpful in cancer risk assessment and prevention. -tissue_expression_ns hsa-mir-155 Neoplasms [unspecific] 24974841 Using microRNA expression profiles the authors were able to distinguish peritumoural tissues according to distance from the primary tumour site. Future application of the method may prove to be useful in early detection of the altered epigenetic regulation in tissue fields representing normal phenotype. This may be helpful in cancer risk assessment and prevention. -tissue_expression_ns hsa-mir-21 Neoplasms [unspecific] 24974841 Using microRNA expression profiles the authors were able to distinguish peritumoural tissues according to distance from the primary tumour site. Future application of the method may prove to be useful in early detection of the altered epigenetic regulation in tissue fields representing normal phenotype. This may be helpful in cancer risk assessment and prevention. -tissue_expression_ns hsa-mir-221 Neoplasms [unspecific] 24974841 Using microRNA expression profiles the authors were able to distinguish peritumoural tissues according to distance from the primary tumour site. Future application of the method may prove to be useful in early detection of the altered epigenetic regulation in tissue fields representing normal phenotype. This may be helpful in cancer risk assessment and prevention. -tissue_expression_ns hsa-mir-106a "Carcinoma, Renal Cell" 24977165 Exploring the miRNA-mRNA regulatory network in clear cell renal cell carcinomas by next-generation sequencing expression profiles. -tissue_expression_ns hsa-mir-135a "Carcinoma, Renal Cell" 24977165 Exploring the miRNA-mRNA regulatory network in clear cell renal cell carcinomas by next-generation sequencing expression profiles. -tissue_expression_ns hsa-mir-142 "Carcinoma, Renal Cell" 24977165 Exploring the miRNA-mRNA regulatory network in clear cell renal cell carcinomas by next-generation sequencing expression profiles. -tissue_expression_ns hsa-mir-206 "Carcinoma, Renal Cell" 24977165 Exploring the miRNA-mRNA regulatory network in clear cell renal cell carcinomas by next-generation sequencing expression profiles. -tissue_expression_ns hsa-mir-21 "Carcinoma, Renal Cell" 24977165 Exploring the miRNA-mRNA regulatory network in clear cell renal cell carcinomas by next-generation sequencing expression profiles. -tissue_expression_ns hsa-mir-216b "Carcinoma, Renal Cell" 24977165 Exploring the miRNA-mRNA regulatory network in clear cell renal cell carcinomas by next-generation sequencing expression profiles. -tissue_expression_ns hsa-mir-3065 "Carcinoma, Renal Cell" 24977165 Exploring the miRNA-mRNA regulatory network in clear cell renal cell carcinomas by next-generation sequencing expression profiles. -tissue_expression_ns hsa-mir-363 "Carcinoma, Renal Cell" 24977165 Exploring the miRNA-mRNA regulatory network in clear cell renal cell carcinomas by next-generation sequencing expression profiles. -tissue_expression_ns hsa-mir-1244 Pallister-Killian Syndrome 24981202 12p microRNA expression in fibroblast cell lines from probands with Pallister-Killian syndrome. -tissue_expression_ns hsa-mir-202 Multiple System Atrophy 24981430 Altered expression of miR-202 in cerebellum of multiple-system atrophy. -tissue_expression_ns hsa-mir-125b Bladder Neoplasms 25014919 "The results revealed a unique microRNA expression signature in the urine supernatants of UCB patients for the development of molecular diagnostic tests. An effective cell-free urinary microRNA-based model was developed using a combined index of the levels of microRNA-99a and microRNA-125b to detect UCB with good discriminating power, high sensitivity and high specificity." -tissue_expression_ns hsa-mir-99a Bladder Neoplasms 25014919 "The results revealed a unique microRNA expression signature in the urine supernatants of UCB patients for the development of molecular diagnostic tests. An effective cell-free urinary microRNA-based model was developed using a combined index of the levels of microRNA-99a and microRNA-125b to detect UCB with good discriminating power, high sensitivity and high specificity." -tissue_expression_ns hsa-mir-195 Colorectal Carcinoma 25027346 "The 15 differentially expressed miRNAs, especially hsa-miR-195 and hsa-miR-20a may be used as potential biomarkers for early detection and screening of colorectal cancer." -tissue_expression_ns hsa-mir-20a Colorectal Carcinoma 25027346 "The 15 differentially expressed miRNAs, especially hsa-miR-195 and hsa-miR-20a may be used as potential biomarkers for early detection and screening of colorectal cancer." -tissue_expression_ns hsa-let-7b "Adenocarcinoma, Lung" 25028925 "The most significant differences in mRNA expression for recurrent tumors compared to non-recurrent tumors were decreases in miR-106b*, -187, -205, -449b, -774* and increases in miR-151-3p, let-7b, miR-215, -520b, and -512-3p." -tissue_expression_ns hsa-mir-106b "Adenocarcinoma, Lung" 25028925 "The most significant differences in mRNA expression for recurrent tumors compared to non-recurrent tumors were decreases in miR-106b*, -187, -205, -449b, -774* and increases in miR-151-3p, let-7b, miR-215, -520b, and -512-3p." -tissue_expression_ns hsa-mir-151a "Adenocarcinoma, Lung" 25028925 "The most significant differences in mRNA expression for recurrent tumors compared to non-recurrent tumors were decreases in miR-106b*, -187, -205, -449b, -774* and increases in miR-151-3p, let-7b, miR-215, -520b, and -512-3p." -tissue_expression_ns hsa-mir-187 "Adenocarcinoma, Lung" 25028925 "The most significant differences in mRNA expression for recurrent tumors compared to non-recurrent tumors were decreases in miR-106b*, -187, -205, -449b, -774* and increases in miR-151-3p, let-7b, miR-215, -520b, and -512-3p." -tissue_expression_ns hsa-mir-205 "Adenocarcinoma, Lung" 25028925 "The most significant differences in mRNA expression for recurrent tumors compared to non-recurrent tumors were decreases in miR-106b*, -187, -205, -449b, -774* and increases in miR-151-3p, let-7b, miR-215, -520b, and -512-3p." -tissue_expression_ns hsa-mir-215 "Adenocarcinoma, Lung" 25028925 "The most significant differences in mRNA expression for recurrent tumors compared to non-recurrent tumors were decreases in miR-106b*, -187, -205, -449b, -774* and increases in miR-151-3p, let-7b, miR-215, -520b, and -512-3p." -tissue_expression_ns hsa-mir-449b "Adenocarcinoma, Lung" 25028925 "The most significant differences in mRNA expression for recurrent tumors compared to non-recurrent tumors were decreases in miR-106b*, -187, -205, -449b, -774* and increases in miR-151-3p, let-7b, miR-215, -520b, and -512-3p." -tissue_expression_ns hsa-mir-512 "Adenocarcinoma, Lung" 25028925 "The most significant differences in mRNA expression for recurrent tumors compared to non-recurrent tumors were decreases in miR-106b*, -187, -205, -449b, -774* and increases in miR-151-3p, let-7b, miR-215, -520b, and -512-3p." -tissue_expression_ns hsa-mir-520b "Adenocarcinoma, Lung" 25028925 "The most significant differences in mRNA expression for recurrent tumors compared to non-recurrent tumors were decreases in miR-106b*, -187, -205, -449b, -774* and increases in miR-151-3p, let-7b, miR-215, -520b, and -512-3p." -tissue_expression_ns hsa-mir-774 "Adenocarcinoma, Lung" 25028925 "The most significant differences in mRNA expression for recurrent tumors compared to non-recurrent tumors were decreases in miR-106b*, -187, -205, -449b, -774* and increases in miR-151-3p, let-7b, miR-215, -520b, and -512-3p." -tissue_expression_ns hsa-mir-204 Breast Neoplasms 25031750 the miR-204 may be a potential diagnostic and prognostic biomarker of breast cancer. -tissue_expression_ns hsa-let-7g "Squamous Cell Carcinoma, Oral" 25050621 "MicroRNAs MiR-218, MiR-125b, and Let-7g predict prognosis in patients with oral cavity squamous cell carcinoma." -tissue_expression_ns hsa-mir-125b "Squamous Cell Carcinoma, Oral" 25050621 "MicroRNAs MiR-218, MiR-125b, and Let-7g predict prognosis in patients with oral cavity squamous cell carcinoma." -tissue_expression_ns hsa-mir-218 "Squamous Cell Carcinoma, Oral" 25050621 "MicroRNAs MiR-218, MiR-125b, and Let-7g predict prognosis in patients with oral cavity squamous cell carcinoma." -tissue_expression_ns hsa-mir-126 Prolactinoma 25064468 Our study is the first to identify a miRNA expression profile associated with bromocriptine-resistant prolactinoma. -tissue_expression_ns hsa-mir-136 Prolactinoma 25064468 Our study is the first to identify a miRNA expression profile associated with bromocriptine-resistant prolactinoma. -tissue_expression_ns hsa-mir-142 Prolactinoma 25064468 Our study is the first to identify a miRNA expression profile associated with bromocriptine-resistant prolactinoma. -tissue_expression_ns hsa-mir-144 Prolactinoma 25064468 Our study is the first to identify a miRNA expression profile associated with bromocriptine-resistant prolactinoma. -tissue_expression_ns hsa-mir-17 Prolactinoma 25064468 Our study is the first to identify a miRNA expression profile associated with bromocriptine-resistant prolactinoma. -tissue_expression_ns hsa-mir-22 Prolactinoma 25064468 Our study is the first to identify a miRNA expression profile associated with bromocriptine-resistant prolactinoma. -tissue_expression_ns hsa-mir-30a Prolactinoma 25064468 Our study is the first to identify a miRNA expression profile associated with bromocriptine-resistant prolactinoma. -tissue_expression_ns hsa-mir-382 Prolactinoma 25064468 Our study is the first to identify a miRNA expression profile associated with bromocriptine-resistant prolactinoma. -tissue_expression_ns hsa-mir-451 Prolactinoma 25064468 Our study is the first to identify a miRNA expression profile associated with bromocriptine-resistant prolactinoma. -tissue_expression_ns hsa-mir-486 Prolactinoma 25064468 Our study is the first to identify a miRNA expression profile associated with bromocriptine-resistant prolactinoma. -tissue_expression_ns hsa-mir-92a Prolactinoma 25064468 Our study is the first to identify a miRNA expression profile associated with bromocriptine-resistant prolactinoma. -tissue_expression_ns Hsa-mir-93 Prolactinoma 25064468 Our study is the first to identify a miRNA expression profile associated with bromocriptine-resistant prolactinoma. -tissue_expression_ns hsa-mir-18a Acute Respiratory Distress Syndrome 25070658 "miR-26a, miR-346, miR-135b, miR-30a/b, miR-344, and miR-18a targeted multiple altered mRNAs." -tissue_expression_ns hsa-mir-133b Neoplasms [unspecific] 25075017 Prognostic microRNA expression signature from examination of colorectal primary and metastatic tumors. -tissue_expression_ns hsa-mir-210 Neoplasms [unspecific] 25075017 Prognostic microRNA expression signature from examination of colorectal primary and metastatic tumors. -tissue_expression_ns hsa-mir-221 Colon Neoplasms 25075256 "Five miRNAs (miR-203-3p, miR-221-3p, miR-342-3p, miR-491-5p and miR-503-5p) were dysregulated in colon cancer tissue (P < 0.05)." -tissue_expression_ns hsa-mir-150 Digeorge Syndrome 25084529 Decreased DGCR8 expression and miRNA dysregulation in individuals with 22q11.2 deletion syndrome. -tissue_expression_ns hsa-mir-185 Digeorge Syndrome 25084529 Decreased DGCR8 expression and miRNA dysregulation in individuals with 22q11.2 deletion syndrome. -tissue_expression_ns hsa-mir-194 Digeorge Syndrome 25084529 Decreased DGCR8 expression and miRNA dysregulation in individuals with 22q11.2 deletion syndrome. -tissue_expression_ns hsa-mir-155 Hypertension 25087597 "In addition, exercise training in SHR increased levels of microRNA-27a (targeting ACE) and microRNA-155 (targeting AT1R) and decreased levels of microRNA-143 (targeting ACE2) in the aortas." -tissue_expression_ns hsa-mir-1246 Pancreatic Neoplasms 25117811 "miR-1246 expression was associated with chemoresistance and CSC-like properties via CCNG2, and could predict worse prognosis in pancreatic cancer patients." -tissue_expression_ns hsa-mir-378 "Carcinoma, Renal Cell, Clear-Cell" 25119741 "The tumors of patients with ccRCC had lower expression of miR-126 and miR-378 during the early stages of disease (T1), but higher expression of these miRNAs during the later stages of disease (T2/T3)." -tissue_expression_ns hsa-mir-126 Lung Neoplasms 25124149 Expression of microRNA miR-126 and miR-200c is associated with prognosis in patients with non-small cell lung cancer. -tissue_expression_ns hsa-mir-200c Lung Neoplasms 25124150 Expression of microRNA miR-126 and miR-201c is associated with prognosis in patients with non-small cell lung cancer. -tissue_expression_ns hsa-mir-17 Lymphoproliferative Disorders 25130212 "Unsupervised nonhierarchical clustering of the viral and cellular microRNAome distinguished non-EBV-associated from EBV-associated samples and identified a separate group of EBV-associated pCNS PTLD that displayed reduced levels of B cell lymphoma associated oncomiRs such as hsa-miR-155, -21, -221 and the hsa-miR-17-92 cluster." -tissue_expression_ns hsa-mir-181b Male Infertility 25141839 "The expression of three out of five selected miRNAs, including miR-34a, miR-181b and miR-122a, showed some degrees of changes following exposure to oxidative stress." -tissue_expression_ns hsa-mir-133a Hypertrophy 25147795 "Fifty-seven miRNAs were expressed differentially between transgenic and littermate controls, of which most abundant miRNAs, miR-133a and 378a, were significantly differentially expressed." -tissue_expression_ns hsa-mir-21 "Carcinoma, Hepatocellular" 25150373 The results of the present study suggested miR-21 expression level could be a novel potential biomarker for HCC prognosis. -tissue_expression_ns hsa-mir-155 Breast Neoplasms 25157366 MiR-155 detection might have a diagnostic value in breast cancer patients. It might be used as an auxiliary biomarker for different clinicopathological breast cancer. -tissue_expression_ns hsa-mir-31 Heart Transplant Rejection 25176944 "We identified seven miRNAs that were differentially expressed between normal and rejecting heart allografts: miR-10a, miR-21, miR-31, miR-92a, miR-142-3p miR-155, and miR-451" -tissue_expression_ns hsa-mir-106b "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 25189575 "Guo investigated regulation and expression of three miRNAs; miR-21, miR-106b and miR-375. The paper reported these miRNAs as potential biomarkers for laryngeal squamous cell carcinoma diagnosis." -tissue_expression_ns hsa-mir-204 Colorectal Carcinoma 25209181 miR-204-5p expression in colorectal cancer: an autophagy-associated gene. -tissue_expression_ns hsa-mir-146a Asthma 25217662 MicroRNA-146a and microRNA-146b expression and anti-inflammatory function in human airway smooth muscle. -tissue_expression_ns hsa-mir-146b Asthma 25217662 MicroRNA-146a and microRNA-146b expression and anti-inflammatory function in human airway smooth muscle. -tissue_expression_ns hsa-mir-21 Inflammatory Bowel Diseases 25222661 "MiRNAs are differentially expressed in both human IBD and murine colitis, with overlap of several IBD-associated miRNAs. The demonstration that miR-21-/- deletion exacerbated CD4+ T-cell-mediated models of colitis provide further evidence that miRNAs play significant roles in the pathogenesis of IBD." -tissue_expression_ns hsa-mir-135b "Adenocarcinoma, Cervical" 25230213 "MiR-135b, miR-192, and miR-194 are altered in uterine cervical ACA, and miR-363-3p is an independent favorable prognostic factor in ACA. These miRNAs could be of value as biomarkers for the diagnosis and prognosis of ACA." -tissue_expression_ns hsa-mir-192 "Adenocarcinoma, Cervical" 25230213 "MiR-135b, miR-192, and miR-194 are altered in uterine cervical ACA, and miR-363-3p is an independent favorable prognostic factor in ACA. These miRNAs could be of value as biomarkers for the diagnosis and prognosis of ACA." -tissue_expression_ns hsa-mir-194 "Adenocarcinoma, Cervical" 25230213 "MiR-135b, miR-192, and miR-194 are altered in uterine cervical ACA, and miR-363-3p is an independent favorable prognostic factor in ACA. These miRNAs could be of value as biomarkers for the diagnosis and prognosis of ACA." -tissue_expression_ns hsa-mir-31 Colorectal Carcinoma 25232271 MicroRNA-31 expression in colorectal serrated pathway progression. -tissue_expression_ns hsa-mir-23b "Carcinoma, Adenoid Cystic" 25240490 "9 microRNAs were downexpressed in sACC cases and overexpressed in bACC tissues (let-7e, miR-23b, miR-27b, miR-193b, miR-320a, miR-320c, miR-768-5p, miR-1280 and miR-1826) relative to their controls." -tissue_expression_ns hsa-mir-155 Lymphoma 25265435 Differential expression of miR-155 and miR-21 in tumor and stroma cells in diffuse large B-cell lymphoma. -tissue_expression_ns hsa-mir-21 Lymphoma 25265435 Differential expression of miR-155 and miR-21 in tumor and stroma cells in diffuse large B-cell lymphoma. -tissue_expression_ns hsa-mir-10a "Carcinoma, Laryngeal" 25266939 MicroRNA-10a-5p and microRNA-34c-5p in laryngeal epithelial premalignant lesions:differential expression and clinicopathological correlation. -tissue_expression_ns hsa-mir-34c "Carcinoma, Laryngeal" 25266939 MicroRNA-10a-5p and microRNA-34c-5p in laryngeal epithelial premalignant lesions:differential expression and clinicopathological correlation. -tissue_expression_ns hsa-mir-215 Breast Neoplasms 25270284 Aberrant miR-215 expression is associated with clinical outcome in breast cancer patients. -tissue_expression_ns hsa-mir-208 Heart Failure 25287062 "miR-208, which was progressively downregulated as RV failure progressed" -tissue_expression_ns hsa-mir-21 Colorectal Carcinoma 25292032 "Our findings suggest that miR-21 has a potential diagnostic value for CRC with a moderate level of overall diagnostic accuracy. Hence, it could be used as auxiliary means for the initial screening of CRC and avoid unnecessary colonoscopy, which is an invasive and expensive procedure." -tissue_expression_ns hsa-mir-34a Neuroblastoma 25292042 "Hsa-miR-34a, for example, targets gene MYC, which regulates hsa-miR-34a in turn." -tissue_expression_ns hsa-mir-143 Intracranial Aneurysm 25300531 "As compared to normal arteries, we identified 157 microRNAs that were differentially expressed in the aneurysmal tissue (Pâ€?â€?.05 and fold change ≥â€?), including 72 upregulated and 85 downregulated." -tissue_expression_ns hsa-mir-23a Osteosarcoma 25322765 We identified miR-23a as a tumor suppressor in osteosarcoma. Our data clarify the mechanism of osteosarcoma progression and demonstrated the potential for exploiting miR-23a as a diagnostic marker for osteosarcoma. -tissue_expression_ns hsa-mir-335 "Squamous Cell Carcinoma, Esophageal" 25337272 "miR-335 expression isan independent prognostic factor for patients with esophageal cancer, which might be a potential valuable biomarker for ESCC." -tissue_expression_ns hsa-mir-151 Breast Neoplasms 25339470 "Specific differentially expressed miRNAs of the three subtypes were identified, including hsa-miR-99a and hsa-miR-151-3p for DCIS breast cancer, hsa-miR-145 and hsa-miR-210 for invasive breast cancer, and has-miR-205 and has-miR-361-5p metastatic breast cancer." -tissue_expression_ns hsa-mir-224 Hepatitis C Virus Infection 25386083 "Differences in miRNA expression were observed between CHC and steatotic CHC, CHC and steatotic liver, but not between steatotic CHC and steatotic liver of metabolic origin." -tissue_expression_ns hsa-mir-33a Hepatitis C Virus Infection 25386083 "Differences in miRNA expression were observed between CHC and steatotic CHC, CHC and steatotic liver, but not between steatotic CHC and steatotic liver of metabolic origin." -tissue_expression_ns hsa-mir-1246 Pancreatic Neoplasms 25388097 "the concomitant evaluation of PaCIC and PaCa-related miRNA marker panels awaits retrospective analyses of larger cohorts, as it should allow for a highly sensitive, minimally-invasive PaCa diagnostics." -tissue_expression_ns hsa-mir-3976 Pancreatic Neoplasms 25388097 "the concomitant evaluation of PaCIC and PaCa-related miRNA marker panels awaits retrospective analyses of larger cohorts, as it should allow for a highly sensitive, minimally-invasive PaCa diagnostics." -tissue_expression_ns hsa-mir-4306 Pancreatic Neoplasms 25388097 "the concomitant evaluation of PaCIC and PaCa-related miRNA marker panels awaits retrospective analyses of larger cohorts, as it should allow for a highly sensitive, minimally-invasive PaCa diagnostics." -tissue_expression_ns hsa-mir-4644 Pancreatic Neoplasms 25388097 "the concomitant evaluation of PaCIC and PaCa-related miRNA marker panels awaits retrospective analyses of larger cohorts, as it should allow for a highly sensitive, minimally-invasive PaCa diagnostics." -tissue_expression_ns hsa-mir-152 Breast Neoplasms 25393370 "For the first time, a different microRNA expression pattern in male and female fBC has been shown. Moreover, the importance of RASSF1A pathway in male fBC carcinogenesis has been confirmed, highlighting a possible role for miR-152 and miR-497 in controlling MAPK and Hippo signalling pathways, regulated by RASSF1A." -tissue_expression_ns hsa-mir-497 Breast Neoplasms 25393370 "For the first time, a different microRNA expression pattern in male and female fBC has been shown. Moreover, the importance of RASSF1A pathway in male fBC carcinogenesis has been confirmed, highlighting a possible role for miR-152 and miR-497 in controlling MAPK and Hippo signalling pathways, regulated by RASSF1A." -tissue_expression_ns hsa-mir-105 Glioma 25415048 "miRNA expression patterns in the malignant progression of gliomas and a novel prognostic classifier, the five-miRNA signature, serve as a prognostic marker for patient risk stratification in anaplastic gliomas, Secondary and Proneural glioblastomas." -tissue_expression_ns hsa-mir-196a Glioma 25415048 "miRNA expression patterns in the malignant progression of gliomas and a novel prognostic classifier, the five-miRNA signature, serve as a prognostic marker for patient risk stratification in anaplastic gliomas, Secondary and Proneural glioblastomas." -tissue_expression_ns hsa-mir-296 Glioma 25415048 "miRNA expression patterns in the malignant progression of gliomas and a novel prognostic classifier, the five-miRNA signature, serve as a prognostic marker for patient risk stratification in anaplastic gliomas, Secondary and Proneural glioblastomas." -tissue_expression_ns hsa-mir-584 Glioma 25415048 "miRNA expression patterns in the malignant progression of gliomas and a novel prognostic classifier, the five-miRNA signature, serve as a prognostic marker for patient risk stratification in anaplastic gliomas, Secondary and Proneural glioblastomas." -tissue_expression_ns hsa-mir-767 Glioma 25415048 "miRNA expression patterns in the malignant progression of gliomas and a novel prognostic classifier, the five-miRNA signature, serve as a prognostic marker for patient risk stratification in anaplastic gliomas, Secondary and Proneural glioblastomas." -tissue_expression_ns hsa-mir-21 Colorectal Carcinoma 25421755 "miR-21 expression may be a valuable biomarker for prediction of poor prognosis in CRC patients with Dukes' stage B, C and D." -tissue_expression_ns hsa-mir-125b "Carcinoma, Colon" 25421775 "miR-145 and other 16 miRNAs may be used as diagnostic molecular markers of colon cancer, and miR100, miR125a-5p, miR125b, miR145 and miR145* may become the molecular markers of colon cancer lymph node metastasis." -tissue_expression_ns hsa-mir-145 "Carcinoma, Colon" 25421775 "miR-145 and other 16 miRNAs may be used as diagnostic molecular markers of colon cancer, and miR100, miR125a-5p, miR125b, miR145 and miR146* may become the molecular markers of colon cancer lymph node metastasis." -tissue_expression_ns hsa-mir-192 "Adenocarcinoma, Gastric-Esophageal Junction" 25429911 "Comprehensive miRNA profiling showed a differential microRNA expression pattern depending on the histomorphologic regression in the multimodality therapy of locally advanced adenocarcinomas of the gastroesophageal junction. Moreover, using single RT-PCR analyses a prognostic impact of miR-222 and miR-302c was detected." -tissue_expression_ns hsa-mir-21 "Adenocarcinoma, Gastric-Esophageal Junction" 25429911 "Comprehensive miRNA profiling showed a differential microRNA expression pattern depending on the histomorphologic regression in the multimodality therapy of locally advanced adenocarcinomas of the gastroesophageal junction. Moreover, using single RT-PCR analyses a prognostic impact of miR-222 and miR-302c was detected." -tissue_expression_ns hsa-mir-222 "Adenocarcinoma, Gastric-Esophageal Junction" 25429911 "Comprehensive miRNA profiling showed a differential microRNA expression pattern depending on the histomorphologic regression in the multimodality therapy of locally advanced adenocarcinomas of the gastroesophageal junction. Moreover, using single RT-PCR analyses a prognostic impact of miR-222 and miR-302c was detected." -tissue_expression_ns hsa-mir-302c "Adenocarcinoma, Gastric-Esophageal Junction" 25429911 "Comprehensive miRNA profiling showed a differential microRNA expression pattern depending on the histomorphologic regression in the multimodality therapy of locally advanced adenocarcinomas of the gastroesophageal junction. Moreover, using single RT-PCR analyses a prognostic impact of miR-222 and miR-302c was detected." -tissue_expression_ns hsa-mir-381 "Adenocarcinoma, Gastric-Esophageal Junction" 25429911 "Comprehensive miRNA profiling showed a differential microRNA expression pattern depending on the histomorphologic regression in the multimodality therapy of locally advanced adenocarcinomas of the gastroesophageal junction. Moreover, using single RT-PCR analyses a prognostic impact of miR-222 and miR-302c was detected." -tissue_expression_ns hsa-mir-549 "Adenocarcinoma, Gastric-Esophageal Junction" 25429911 "Comprehensive miRNA profiling showed a differential microRNA expression pattern depending on the histomorphologic regression in the multimodality therapy of locally advanced adenocarcinomas of the gastroesophageal junction. Moreover, using single RT-PCR analyses a prognostic impact of miR-222 and miR-302c was detected." -tissue_expression_ns hsa-let-7i Ovarian Disease 25451316 "let-7i-5p, miR-122,miR-152-5p and miR-25-3p could act as diagnostic biomarkers in ovarian cancer." -tissue_expression_ns hsa-mir-122 Ovarian Disease 25451316 "let-7i-5p, miR-122,miR-152-5p and miR-25-3p could act as diagnostic biomarkers in ovarian cancer." -tissue_expression_ns hsa-mir-152 Ovarian Disease 25451316 "let-7i-5p, miR-122,miR-152-5p and miR-25-3p could act as diagnostic biomarkers in ovarian cancer." -tissue_expression_ns hsa-mir-25 Ovarian Disease 25451316 "let-7i-5p, miR-122,miR-152-5p and miR-25-3p could act as diagnostic biomarkers in ovarian cancer." -tissue_expression_ns hsa-mir-34 Neoplasms [unspecific] 25452192 miR-34 family members could be expected to become potential diagnostic and prognostic biomarkers in some types of human cancers. Further well-designed and larger sample studies are surely warranted to identify the role of the miR-34 family in the occurrence and development of tumors. -tissue_expression_ns hsa-mir-21 Glioma 25452796 "Among the six identified differentially expressed miRNAs, hsa-miR-21 and hsa-miR-612 have been previously reported to be associated with glioma." -tissue_expression_ns hsa-mir-103a Mesothelioma 25469901 the use of biomarkers of different molecular classes might be a reasonable approach to assemble a biomarker panel. -tissue_expression_ns hsa-mir-184 "Squamous Cell Carcinoma, Oral" 25482863 "Our results corroborate the previous findings on the overexpression of mir-21 and downregulation of miR-138 in OSCC. As the expression of miR-184 is controversial in tongue/oral cancer, the downregulation may be specific to tumor anatomical localization. On the other hand, to the best of our knowledge, this is the first report to show the association of miR-155 with tobacco chewing and the downregulation of miR-125b-2* in OSCC. Computational predictions suggest that miR-125b-2* may have a role in alternative splicing." -tissue_expression_ns hsa-let-7a Multiple Sclerosis 25487315 some miRNA subsets may be potential biomarkers for MS activity. -tissue_expression_ns hsa-mir-648a Multiple Sclerosis 25487315 some miRNA subsets may be potential biomarkers for MS activity. -tissue_expression_ns hsa-mir-92a Multiple Sclerosis 25487315 some miRNA subsets may be potential biomarkers for MS activity. -tissue_expression_ns hsa-mir-106a Preeclampsia 25499681 facilitate further investigation of aberrant expression of miRNAs in the pathology of preeclampsia. -tissue_expression_ns hsa-mir-363 Preeclampsia 25499681 facilitate further investigation of aberrant expression of miRNAs in the pathology of preeclampsia. -tissue_expression_ns hsa-mir-126 Osteosarcoma 25510179 expression of miR-126 increased the sensitivity of osteosarcoma cells to EGCG through induction of apoptosis. -tissue_expression_ns hsa-mir-96 Bladder Neoplasms 25511320 Urinary miRNA-96 is a good noninvasive diagnostic biomarker for bladder cancer. -tissue_expression_ns hsa-mir-101 "Squamous Cell Carcinoma, Esophageal" 25538231 A significant negative correlation exists between miR-101 or miR-217 and MALAT1 in 42 pairs of ESCC tissue samples and adjacent normal tissues. Mice xenograft data also support the tumor suppressor role of both miRNAs in ESCCs. -tissue_expression_ns hsa-mir-217 "Squamous Cell Carcinoma, Esophageal" 25538231 A significant negative correlation exists between miR-101 or miR-217 and MALAT1 in 42 pairs of ESCC tissue samples and adjacent normal tissues. Mice xenograft data also support the tumor suppressor role of both miRNAs in ESCCs. -tissue_expression_ns hsa-mir-15a Breast Neoplasms 25550542 MiR-15a expression levels could be a promising biological and prognostic marker for overall survival especially in triple-negative BC cases. -tissue_expression_ns hsa-mir-155 Human Papilloma Virus Infection 25550598 Evaluation of miRNA expression might be helpful to distinguish different cervical lesions and might be able to help in the prediction of HPV infection outcome. epithelial cell adhesion molecule -tissue_expression_ns hsa-mir-196a Human Papilloma Virus Infection 25550598 Evaluation of miRNA expression might be helpful to distinguish different cervical lesions and might be able to help in the prediction of HPV infection outcome. epithelial cell adhesion molecule -tissue_expression_ns hsa-mir-203 Human Papilloma Virus Infection 25550598 Evaluation of miRNA expression might be helpful to distinguish different cervical lesions and might be able to help in the prediction of HPV infection outcome. epithelial cell adhesion molecule -tissue_expression_ns hsa-mir-27a Human Papilloma Virus Infection 25550598 Evaluation of miRNA expression might be helpful to distinguish different cervical lesions and might be able to help in the prediction of HPV infection outcome. epithelial cell adhesion molecule -tissue_expression_ns hsa-mir-34a Human Papilloma Virus Infection 25550598 Evaluation of miRNA expression might be helpful to distinguish different cervical lesions and might be able to help in the prediction of HPV infection outcome. epithelial cell adhesion molecule -tissue_expression_ns hsa-mir-132 Inflammation 25564423 We assessed miRNA and mRNA expression in lung infiltrating mononuclear cells following exposure to SEB and found 89 miRNA that were dysregulated (>2-fold) compared with vehicle controls. -tissue_expression_ns hsa-mir-125a Colorectal Adenoma 25586944 "several miRNAs were abnormally expressed in colorectal lesions, identified new deregulated miRs, and showed that several miRNAs could mark the transition from NOR to CRA, thereby marking progression from the early steps of cancer." -tissue_expression_ns hsa-mir-145 Colorectal Adenoma 25586944 "several miRNAs were abnormally expressed in colorectal lesions, identified new deregulated miRs, and showed that several miRNAs could mark the transition from NOR to CRA, thereby marking progression from the early steps of cancer." -tissue_expression_ns hsa-mir-15b Colorectal Adenoma 25586944 "several miRNAs were abnormally expressed in colorectal lesions, identified new deregulated miRs, and showed that several miRNAs could mark the transition from NOR to CRA, thereby marking progression from the early steps of cancer." -tissue_expression_ns hsa-mir-16 Colorectal Adenoma 25586944 "several miRNAs were abnormally expressed in colorectal lesions, identified new deregulated miRs, and showed that several miRNAs could mark the transition from NOR to CRA, thereby marking progression from the early steps of cancer." -tissue_expression_ns hsa-mir-21 Colorectal Adenoma 25586944 "several miRNAs were abnormally expressed in colorectal lesions, identified new deregulated miRs, and showed that several miRNAs could mark the transition from NOR to CRA, thereby marking progression from the early steps of cancer." -tissue_expression_ns hsa-mir-24 Colorectal Adenoma 25586944 "several miRNAs were abnormally expressed in colorectal lesions, identified new deregulated miRs, and showed that several miRNAs could mark the transition from NOR to CRA, thereby marking progression from the early steps of cancer." -tissue_expression_ns hsa-mir-320 Colorectal Adenoma 25586944 "several miRNAs were abnormally expressed in colorectal lesions, identified new deregulated miRs, and showed that several miRNAs could mark the transition from NOR to CRA, thereby marking progression from the early steps of cancer." -tissue_expression_ns hsa-mir-320b Colorectal Adenoma 25586944 "several miRNAs were abnormally expressed in colorectal lesions, identified new deregulated miRs, and showed that several miRNAs could mark the transition from NOR to CRA, thereby marking progression from the early steps of cancer." -tissue_expression_ns hsa-mir-378 Colorectal Adenoma 25586944 "several miRNAs were abnormally expressed in colorectal lesions, identified new deregulated miRs, and showed that several miRNAs could mark the transition from NOR to CRA, thereby marking progression from the early steps of cancer." -tissue_expression_ns hsa-mir-126 Colorectal Carcinoma 25592646 "The intra-tumoural expression of EGFL7 in early stages of CRC may influence the risk of post-surgical recurrence. Differential expression of miRNA-126 seems more pronounced in disseminated disease, which supports its role as a regulator in the metastatic process." -tissue_expression_ns hsa-mir-107 Glioma 25596705 expression level of miR-107 may be a novel and valuable prognostic factor in glioma. -tissue_expression_ns hsa-mir-26a Colorectal Carcinoma 25611389 Genome-wide mRNA and miRNA expression profiling reveal multiple regulatory networks in colorectal cancer. -tissue_expression_ns hsa-mir-375 "Squamous Cell Carcinoma, Tongue" 25633534 "miR-375 inhibits the cell growth, and its expression is correlated with clinical outcomes in TSCC." -tissue_expression_ns hsa-mir-93 "Carcinoma, Hepatocellular" 25633810 "miR-93 stimulated cell proliferation,migration, and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC." -tissue_expression_ns hsa-mir-146a Psoriasis 25662483 "In the mouse model of Aldara-induced skin inflammation, the level of miR-146a increased" -tissue_expression_ns hsa-mir-1203 "Small Cell Carcinoma, Esophageal" 25667451 The expression profiles of microRNAs in tumors may represent a novel predictor for postoperative outcomes in patients with SCCE. -tissue_expression_ns hsa-mir-1249 "Small Cell Carcinoma, Esophageal" 25667451 The expression profiles of microRNAs in tumors may represent a novel predictor for postoperative outcomes in patients with SCCE. -tissue_expression_ns hsa-mir-3619 "Small Cell Carcinoma, Esophageal" 25667451 The expression profiles of microRNAs in tumors may represent a novel predictor for postoperative outcomes in patients with SCCE. -tissue_expression_ns hsa-mir-4419b "Small Cell Carcinoma, Esophageal" 25667451 The expression profiles of microRNAs in tumors may represent a novel predictor for postoperative outcomes in patients with SCCE. -tissue_expression_ns hsa-mir-4648 "Small Cell Carcinoma, Esophageal" 25667451 The expression profiles of microRNAs in tumors may represent a novel predictor for postoperative outcomes in patients with SCCE. -tissue_expression_ns hsa-mir-4664 "Small Cell Carcinoma, Esophageal" 25667451 The expression profiles of microRNAs in tumors may represent a novel predictor for postoperative outcomes in patients with SCCE. -tissue_expression_ns hsa-mir-143 "Carcinoma, Esophageal" 25667498 Alterations of miRNA expression in ESCC can be correlated with the presence of common risk factors. The altered expression of certain miRNAs could be used as novel molecular markers of esophageal carcinoma. -tissue_expression_ns hsa-mir-203 "Carcinoma, Esophageal" 25667498 Alterations of miRNA expression in ESCC can be correlated with the presence of common risk factors. The altered expression of certain miRNAs could be used as novel molecular markers of esophageal carcinoma. -tissue_expression_ns hsa-mir-205 "Carcinoma, Esophageal" 25667498 Alterations of miRNA expression in ESCC can be correlated with the presence of common risk factors. The altered expression of certain miRNAs could be used as novel molecular markers of esophageal carcinoma. -tissue_expression_ns hsa-mir-21 "Carcinoma, Esophageal" 25667498 Alterations of miRNA expression in ESCC can be correlated with the presence of common risk factors. The altered expression of certain miRNAs could be used as novel molecular markers of esophageal carcinoma. -tissue_expression_ns hsa-mir-221 "Carcinoma, Esophageal" 25667498 Alterations of miRNA expression in ESCC can be correlated with the presence of common risk factors. The altered expression of certain miRNAs could be used as novel molecular markers of esophageal carcinoma. -tissue_expression_ns hsa-mir-23a Gastric Neoplasms 25674252 These results suggest that the dysregulation of miR-23a and miR-23b may be implicated in the progression of human GC. Combined expression of miR-23a and miR-23b appears to be a valuable marker for prognosis of this disease. -tissue_expression_ns hsa-mir-23b Gastric Neoplasms 25674252 These results suggest that the dysregulation of miR-23a and miR-23b may be implicated in the progression of human GC. Combined expression of miR-23a and miR-23b appears to be a valuable marker for prognosis of this disease. -tissue_expression_ns hsa-mir-19b Parkinson Disease 25675938 Our findings indicate that dysregulation of the microRNA miR-19b occurs in the prodromal stage of synucleinopathies. -tissue_expression_ns hsa-mir-29a Parkinson Disease 25675938 Our findings indicate that dysregulation of the microRNA miR-19b occurs in the prodromal stage of synucleinopathies. -tissue_expression_ns hsa-mir-29c Parkinson Disease 25675938 Our findings indicate that dysregulation of the microRNA miR-19b occurs in the prodromal stage of synucleinopathies. -tissue_expression_ns hsa-mir-1207 Gastric Neoplasms 25688358 "Multivariate analysis showed that stromal reaction type, lymphovascular invasion, pathological T category and TNM stage, and expression of miR-1207-5p were independent risk factors of LNM. MiR-1207-5p could serve as a useful biomarker in the prediction of LNM in gastric cancer." -tissue_expression_ns hsa-mir-330 "Muscular Dystrophy, Facioscapulohumeral" 25692472 "This work provides new candidate mechanisms potentially involved in the onset of FSHD pathology. Whether these FSHD specific miRNAs cause deregulations during fetal development, or protect against the appearance of the FSHD phenotype until the second decade of life still needs to be investigated." -tissue_expression_ns hsa-mir-331 "Muscular Dystrophy, Facioscapulohumeral" 25692472 "This work provides new candidate mechanisms potentially involved in the onset of FSHD pathology. Whether these FSHD specific miRNAs cause deregulations during fetal development, or protect against the appearance of the FSHD phenotype until the second decade of life still needs to be investigated." -tissue_expression_ns hsa-mir-34a "Muscular Dystrophy, Facioscapulohumeral" 25692472 "This work provides new candidate mechanisms potentially involved in the onset of FSHD pathology. Whether these FSHD specific miRNAs cause deregulations during fetal development, or protect against the appearance of the FSHD phenotype until the second decade of life still needs to be investigated." -tissue_expression_ns hsa-mir-380 "Muscular Dystrophy, Facioscapulohumeral" 25692472 "This work provides new candidate mechanisms potentially involved in the onset of FSHD pathology. Whether these FSHD specific miRNAs cause deregulations during fetal development, or protect against the appearance of the FSHD phenotype until the second decade of life still needs to be investigated." -tissue_expression_ns hsa-mir-516b "Muscular Dystrophy, Facioscapulohumeral" 25692472 "This work provides new candidate mechanisms potentially involved in the onset of FSHD pathology. Whether these FSHD specific miRNAs cause deregulations during fetal development, or protect against the appearance of the FSHD phenotype until the second decade of life still needs to be investigated." -tissue_expression_ns hsa-mir-517 "Muscular Dystrophy, Facioscapulohumeral" 25692472 "This work provides new candidate mechanisms potentially involved in the onset of FSHD pathology. Whether these FSHD specific miRNAs cause deregulations during fetal development, or protect against the appearance of the FSHD phenotype until the second decade of life still needs to be investigated." -tissue_expression_ns hsa-mir-582 "Muscular Dystrophy, Facioscapulohumeral" 25692472 "This work provides new candidate mechanisms potentially involved in the onset of FSHD pathology. Whether these FSHD specific miRNAs cause deregulations during fetal development, or protect against the appearance of the FSHD phenotype until the second decade of life still needs to be investigated." -tissue_expression_ns hsa-mir-625 "Muscular Dystrophy, Facioscapulohumeral" 25692472 "This work provides new candidate mechanisms potentially involved in the onset of FSHD pathology. Whether these FSHD specific miRNAs cause deregulations during fetal development, or protect against the appearance of the FSHD phenotype until the second decade of life still needs to be investigated." -tissue_expression_ns hsa-mir-155 Mycosis Fungoides 25698383 These results by identifying a number of differentially expressed microRNAs add further insight into the molecular pathogenesis of folliculotropic MF and large cell transformation of MF. -tissue_expression_ns hsa-mir-181b Mycosis Fungoides 25698383 These results by identifying a number of differentially expressed microRNAs add further insight into the molecular pathogenesis of folliculotropic MF and large cell transformation of MF. -tissue_expression_ns hsa-mir-223 Mycosis Fungoides 25698383 These results by identifying a number of differentially expressed microRNAs add further insight into the molecular pathogenesis of folliculotropic MF and large cell transformation of MF. -tissue_expression_ns hsa-mir-326 Mycosis Fungoides 25698383 These results by identifying a number of differentially expressed microRNAs add further insight into the molecular pathogenesis of folliculotropic MF and large cell transformation of MF. -tissue_expression_ns hsa-mir-206 Muscle Diseases [unspecific] 25703017 "Thirty-six miRNAs were differentially expressed between prenatal and postnatal stages of muscle development including several myomiRs (miR-1, miR-206 and let-7 families)." -tissue_expression_ns hsa-mir-183 Prostate Neoplasms 25720086 Urinary miR-183 and miR-205 do not surpass PCA3 in urine as predictive markers for prostate biopsy outcome despite their highly dysregulated expression in prostate cancer tissue. -tissue_expression_ns hsa-mir-205 Prostate Neoplasms 25720086 Urinary miR-183 and miR-205 do not surpass PCA3 in urine as predictive markers for prostate biopsy outcome despite their highly dysregulated expression in prostate cancer tissue. -tissue_expression_ns hsa-let-7a "Carcinoma, Thyroid, Papillary" 25720323 This comprehensive study complements the existing knowledge about deregulated microRNAs in the development of well-differentiated thyroid cancer and identifies novel markers associated with recurrence-free survival. -tissue_expression_ns hsa-mir-1179 "Carcinoma, Thyroid, Papillary" 25720323 This comprehensive study complements the existing knowledge about deregulated microRNAs in the development of well-differentiated thyroid cancer and identifies novel markers associated with recurrence-free survival. -tissue_expression_ns hsa-mir-146b "Carcinoma, Thyroid, Papillary" 25720323 This comprehensive study complements the existing knowledge about deregulated microRNAs in the development of well-differentiated thyroid cancer and identifies novel markers associated with recurrence-free survival. -tissue_expression_ns hsa-mir-192 "Carcinoma, Thyroid, Papillary" 25720323 This comprehensive study complements the existing knowledge about deregulated microRNAs in the development of well-differentiated thyroid cancer and identifies novel markers associated with recurrence-free survival. -tissue_expression_ns hsa-mir-204 "Carcinoma, Thyroid, Papillary" 25720323 This comprehensive study complements the existing knowledge about deregulated microRNAs in the development of well-differentiated thyroid cancer and identifies novel markers associated with recurrence-free survival. -tissue_expression_ns hsa-mir-221 "Carcinoma, Thyroid, Papillary" 25720323 This comprehensive study complements the existing knowledge about deregulated microRNAs in the development of well-differentiated thyroid cancer and identifies novel markers associated with recurrence-free survival. -tissue_expression_ns hsa-mir-222 "Carcinoma, Thyroid, Papillary" 25720323 This comprehensive study complements the existing knowledge about deregulated microRNAs in the development of well-differentiated thyroid cancer and identifies novel markers associated with recurrence-free survival. -tissue_expression_ns hsa-mir-7 "Carcinoma, Thyroid, Papillary" 25720323 This comprehensive study complements the existing knowledge about deregulated microRNAs in the development of well-differentiated thyroid cancer and identifies novel markers associated with recurrence-free survival. -tissue_expression_ns hsa-mir-1914 "Carcinoma, Gastric" 25730011 The miRNA expression patterns in different gastric adenocarcinoma subtypes may help discriminate between signet-ring cell and tubular gland cancer or other gastric cancer subtypes that would otherwise be difficult to identify using routine histological and immunohistochemical analyses. These preliminary data should be verified in further prospective studies. -tissue_expression_ns hsa-mir-499 "Carcinoma, Gastric" 25730011 The miRNA expression patterns in different gastric adenocarcinoma subtypes may help discriminate between signet-ring cell and tubular gland cancer or other gastric cancer subtypes that would otherwise be difficult to identify using routine histological and immunohistochemical analyses. These preliminary data should be verified in further prospective studies. -tissue_expression_ns hsa-mir-524 "Carcinoma, Gastric" 25730011 The miRNA expression patterns in different gastric adenocarcinoma subtypes may help discriminate between signet-ring cell and tubular gland cancer or other gastric cancer subtypes that would otherwise be difficult to identify using routine histological and immunohistochemical analyses. These preliminary data should be verified in further prospective studies. -tissue_expression_ns hsa-mir-628 "Carcinoma, Gastric" 25730011 The miRNA expression patterns in different gastric adenocarcinoma subtypes may help discriminate between signet-ring cell and tubular gland cancer or other gastric cancer subtypes that would otherwise be difficult to identify using routine histological and immunohistochemical analyses. These preliminary data should be verified in further prospective studies. -tissue_expression_ns hsa-mir-125a Head And Neck Adenoid Cystic Carcinoma 25750274 Our data showed significantly different expression patterns of mircoRNA in HNACC and HNSCC supporting the theory of tumor-specific expression and giving hints for different clinical behavior. review -tissue_expression_ns hsa-mir-199a Head And Neck Adenoid Cystic Carcinoma 25750274 Our data showed significantly different expression patterns of mircoRNA in HNACC and HNSCC supporting the theory of tumor-specific expression and giving hints for different clinical behavior. review -tissue_expression_ns hsa-mir-199b Head And Neck Adenoid Cystic Carcinoma 25750274 Our data showed significantly different expression patterns of mircoRNA in HNACC and HNSCC supporting the theory of tumor-specific expression and giving hints for different clinical behavior. review -tissue_expression_ns hsa-mir-214 Head And Neck Adenoid Cystic Carcinoma 25750274 Our data showed significantly different expression patterns of mircoRNA in HNACC and HNSCC supporting the theory of tumor-specific expression and giving hints for different clinical behavior. review -tissue_expression_ns hsa-mir-574 Head And Neck Adenoid Cystic Carcinoma 25750274 Our data showed significantly different expression patterns of mircoRNA in HNACC and HNSCC supporting the theory of tumor-specific expression and giving hints for different clinical behavior. review -tissue_expression_ns hsa-mir-106b "Carcinoma, Colon" 25755775 In situ hybridization analysis of the expression of miR-106b in colonic cancer. -tissue_expression_ns hsa-mir-122 Obesity 25769350 "Deregulation of miR-33 and miR-122, as major regulators of lipid metabolism in liver, has been related to obesity and metabolic syndrome." -tissue_expression_ns hsa-mir-146b "Carcinoma, Thyroid, Papillary" 25771986 "Since miR-146b-5p was mainly expressed in PTC including FVPTC and was not expressed in most FTC, PDTC, or ATC, it may serve as a useful diagnostic marker for PTC. ISH is a useful method to analyze microRNA expression in formalin-fixed paraffin-embedded thyroid tissues." -tissue_expression_ns hsa-mir-21 "Carcinoma, Thyroid, Papillary" 25771986 "Since miR-146b-5p was mainly expressed in PTC including FVPTC and was not expressed in most FTC, PDTC, or ATC, it may serve as a useful diagnostic marker for PTC. ISH is a useful method to analyze microRNA expression in formalin-fixed paraffin-embedded thyroid tissues." -tissue_expression_ns hsa-mir-106a Colorectal Carcinoma 25773836 "Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior." -tissue_expression_ns hsa-mir-127 Colorectal Carcinoma 25773836 "Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior." -tissue_expression_ns hsa-mir-133a Colorectal Carcinoma 25773836 "Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior." -tissue_expression_ns hsa-mir-133b Colorectal Carcinoma 25773836 "Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior." -tissue_expression_ns hsa-mir-135b Colorectal Carcinoma 25773836 "Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior." -tissue_expression_ns hsa-mir-143 Colorectal Carcinoma 25773836 "Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior." -tissue_expression_ns hsa-mir-145 Colorectal Carcinoma 25773836 "Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior." -tissue_expression_ns hsa-mir-155 Colorectal Carcinoma 25773836 "Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior." -tissue_expression_ns hsa-mir-182 Colorectal Carcinoma 25773836 "Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior." -tissue_expression_ns hsa-mir-200a Colorectal Carcinoma 25773836 "Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior." -tissue_expression_ns hsa-mir-200c Colorectal Carcinoma 25773836 "Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior." -tissue_expression_ns hsa-mir-362 Colorectal Carcinoma 25773836 "Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior." -tissue_expression_ns hsa-mir-203 "Adenocarcinoma, Esophageal" 25784377 We suggest that miRNA expression profiling expands current knowledge in molecular pathology of Barrett's-based carcinogenesis and enables identification of molecular biomarkers for early detection of BE dysplasia and progression to EAC. -tissue_expression_ns hsa-mir-205 "Adenocarcinoma, Esophageal" 25784377 We suggest that miRNA expression profiling expands current knowledge in molecular pathology of Barrett's-based carcinogenesis and enables identification of molecular biomarkers for early detection of BE dysplasia and progression to EAC. -tissue_expression_ns hsa-mir-210 "Adenocarcinoma, Esophageal" 25784377 We suggest that miRNA expression profiling expands current knowledge in molecular pathology of Barrett's-based carcinogenesis and enables identification of molecular biomarkers for early detection of BE dysplasia and progression to EAC. -tissue_expression_ns hsa-mir-378 "Adenocarcinoma, Esophageal" 25784377 We suggest that miRNA expression profiling expands current knowledge in molecular pathology of Barrett's-based carcinogenesis and enables identification of molecular biomarkers for early detection of BE dysplasia and progression to EAC. -tissue_expression_ns hsa-mir-140 Osteoarthritis 25785087 We verified that miR-140 and miR-455 were associated with cartilage development -tissue_expression_ns hsa-mir-9 Osteoarthritis 25785087 "miR-9 and miR-98 were involved in the endochondral ossification, suggesting they may be also the key regulators in the process of endochondral ossification." -tissue_expression_ns hsa-mir-98 Osteoarthritis 25785087 "miR-9 and miR-98 were involved in the endochondral ossification, suggesting they may be also the key regulators in the process of endochondral ossification." -tissue_expression_ns hsa-mir-141 Neoplasms [unspecific] 25789530 miR-141 as a prognostic and diagnostic biomarker in different types of cancer -tissue_expression_ns hsa-mir-145 Neoplasms [unspecific] 25792469 "In conclusion, our findings suggest that miR-145 expression is associated with overall survival (OS) in cancer patients and can serve as a promising biomarker for monitoring prognosis." -tissue_expression_ns hsa-mir-517a Preeclampsia 25799546 Placental expression of miR-517a/b and miR-517c contributes to trophoblast dysfunction and preeclampsia. -tissue_expression_ns hsa-mir-517b Preeclampsia 25799546 Placental expression of miR-517a/b and miR-517c contributes to trophoblast dysfunction and preeclampsia. -tissue_expression_ns hsa-mir-517c Preeclampsia 25799546 Placental expression of miR-517a/b and miR-517c contributes to trophoblast dysfunction and preeclampsia. -tissue_expression_ns hsa-mir-1 Colorectal Adenocarcinoma 25803870 Identification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma. -tissue_expression_ns hsa-mir-135b Colorectal Adenocarcinoma 25803870 Identification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma. -tissue_expression_ns hsa-mir-145 Colorectal Adenocarcinoma 25803870 Identification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma. -tissue_expression_ns hsa-mir-3195 Colorectal Adenocarcinoma 25803870 Identification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma. -tissue_expression_ns hsa-mir-429 Colorectal Adenocarcinoma 25803870 Identification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma. -tissue_expression_ns hsa-mir-4469 Colorectal Adenocarcinoma 25803870 Identification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma. -tissue_expression_ns hsa-mir-4510 Colorectal Adenocarcinoma 25803870 Identification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma. -tissue_expression_ns hsa-mir-4770 Colorectal Adenocarcinoma 25803870 Identification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma. -tissue_expression_ns hsa-mir-549 Colorectal Adenocarcinoma 25803870 Identification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma. -tissue_expression_ns hsa-mir-552 Colorectal Adenocarcinoma 25803870 Identification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma. -tissue_expression_ns hsa-mir-96 Colorectal Adenocarcinoma 25803870 Identification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma. -tissue_expression_ns hsa-mir-99b Colorectal Adenocarcinoma 25803870 Identification and validation of potential biomarkers for the detection of dysregulated microRNA by qPCR in patients with colorectal adenocarcinoma. -tissue_expression_ns hsa-mir-211 Medulloepithelioma 25807141 "We report significantly dysregulated miRNAs in intraocular ME tumors, which exhibited abnormal profiles in other cancers as well such as retinoblastoma and glioblastoma. Pathway analysis of all dysregulated miRNAs shared commonalities with other cancer pathways." -tissue_expression_ns hsa-mir-509 Medulloepithelioma 25807141 "We report significantly dysregulated miRNAs in intraocular ME tumors, which exhibited abnormal profiles in other cancers as well such as retinoblastoma and glioblastoma. Pathway analysis of all dysregulated miRNAs shared commonalities with other cancer pathways." -tissue_expression_ns hsa-mir-1237 Spinal Chordoma 25850393 The data from the current study identified a total of 29 differentially expressed miRNAs in chordoma tissues and reduced miR-1237-3p expression was associated with chordoma invasion and worse recurrence-free survival of the patients. -tissue_expression_ns hsa-mir-143 "Carcinoma, Lung, Non-Small-Cell" 25862841 miRNA expression profiling of sputum and BAL fluids represent a potential means to detect early-stage NSCLC. -tissue_expression_ns hsa-mir-155 "Carcinoma, Lung, Non-Small-Cell" 25862841 miRNA expression profiling of sputum and BAL fluids represent a potential means to detect early-stage NSCLC. -tissue_expression_ns hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 25862841 miRNA expression profiling of sputum and BAL fluids represent a potential means to detect early-stage NSCLC. -tissue_expression_ns hsa-mir-210 "Carcinoma, Lung, Non-Small-Cell" 25862841 miRNA expression profiling of sputum and BAL fluids represent a potential means to detect early-stage NSCLC. -tissue_expression_ns hsa-mir-372 "Carcinoma, Lung, Non-Small-Cell" 25862841 miRNA expression profiling of sputum and BAL fluids represent a potential means to detect early-stage NSCLC. -tissue_expression_ns hsa-let-7c Non-Traumatic Osteonecrosis 25863178 Our data also manifests that the signaling pathways regulated by these differentially expressed miRNAs might be important in the pathogenesis of non-traumatic ONFH. -tissue_expression_ns hsa-let-7i Non-Traumatic Osteonecrosis 25863178 Our data also manifests that the signaling pathways regulated by these differentially expressed miRNAs might be important in the pathogenesis of non-traumatic ONFH. -tissue_expression_ns hsa-mir-146b Non-Traumatic Osteonecrosis 25863178 Our data also manifests that the signaling pathways regulated by these differentially expressed miRNAs might be important in the pathogenesis of non-traumatic ONFH. -tissue_expression_ns hsa-mir-320e Non-Traumatic Osteonecrosis 25863178 Our data also manifests that the signaling pathways regulated by these differentially expressed miRNAs might be important in the pathogenesis of non-traumatic ONFH. -tissue_expression_ns hsa-mir-335 Non-Traumatic Osteonecrosis 25863178 Our data also manifests that the signaling pathways regulated by these differentially expressed miRNAs might be important in the pathogenesis of non-traumatic ONFH. -tissue_expression_ns hsa-mir-197 "Carcinoma, Lung, Non-Small-Cell" 25867273 The cost-effective expression analysis of miR-197 could constitute a novel molecular tool for NSCLC management. -tissue_expression_ns hsa-let-7d "Carcinoma, Lung, Non-Small-Cell" 25873351 mRNA and microRNA expression profiles of radioresistant NCI-H520 non-small cell lung cancer cells. -tissue_expression_ns hsa-mir-127 "Carcinoma, Lung, Non-Small-Cell" 25873351 mRNA and microRNA expression profiles of radioresistant NCI-H520 non-small cell lung cancer cells. -tissue_expression_ns hsa-mir-155 "Carcinoma, Lung, Non-Small-Cell" 25873351 mRNA and microRNA expression profiles of radioresistant NCI-H520 non-small cell lung cancer cells. -tissue_expression_ns hsa-mir-103 Intrahepatic Cholangiocarcinoma 25880914 "In this study, a 30-miRNA signature for distinguishing ICC from NIBD, and a 3-miRNA signature for evaluating prognosis of ICC were established, which might be able to serve as biomarkers for prognosis of ICC. Further studies focusing on these miRNAs may shed light on the mechanisms associated with ICC pathogenesis and progression." -tissue_expression_ns hsa-mir-146a Intrahepatic Cholangiocarcinoma 25880914 "In this study, a 30-miRNA signature for distinguishing ICC from NIBD, and a 3-miRNA signature for evaluating prognosis of ICC were established, which might be able to serve as biomarkers for prognosis of ICC. Further studies focusing on these miRNAs may shed light on the mechanisms associated with ICC pathogenesis and progression." -tissue_expression_ns hsa-mir-216a Intrahepatic Cholangiocarcinoma 25880914 "In this study, a 30-miRNA signature for distinguishing ICC from NIBD, and a 3-miRNA signature for evaluating prognosis of ICC were established, which might be able to serve as biomarkers for prognosis of ICC. Further studies focusing on these miRNAs may shed light on the mechanisms associated with ICC pathogenesis and progression." -tissue_expression_ns hsa-mir-216b Intrahepatic Cholangiocarcinoma 25880914 "In this study, a 30-miRNA signature for distinguishing ICC from NIBD, and a 3-miRNA signature for evaluating prognosis of ICC were established, which might be able to serve as biomarkers for prognosis of ICC. Further studies focusing on these miRNAs may shed light on the mechanisms associated with ICC pathogenesis and progression." -tissue_expression_ns hsa-mir-217 Intrahepatic Cholangiocarcinoma 25880914 "In this study, a 30-miRNA signature for distinguishing ICC from NIBD, and a 3-miRNA signature for evaluating prognosis of ICC were established, which might be able to serve as biomarkers for prognosis of ICC. Further studies focusing on these miRNAs may shed light on the mechanisms associated with ICC pathogenesis and progression." -tissue_expression_ns hsa-mir-338 Intrahepatic Cholangiocarcinoma 25880914 "In this study, a 30-miRNA signature for distinguishing ICC from NIBD, and a 3-miRNA signature for evaluating prognosis of ICC were established, which might be able to serve as biomarkers for prognosis of ICC. Further studies focusing on these miRNAs may shed light on the mechanisms associated with ICC pathogenesis and progression." -tissue_expression_ns hsa-mir-513 Intrahepatic Cholangiocarcinoma 25880914 "In this study, a 30-miRNA signature for distinguishing ICC from NIBD, and a 3-miRNA signature for evaluating prognosis of ICC were established, which might be able to serve as biomarkers for prognosis of ICC. Further studies focusing on these miRNAs may shed light on the mechanisms associated with ICC pathogenesis and progression." -tissue_expression_ns hsa-mir-652 Intrahepatic Cholangiocarcinoma 25880914 "In this study, a 30-miRNA signature for distinguishing ICC from NIBD, and a 3-miRNA signature for evaluating prognosis of ICC were established, which might be able to serve as biomarkers for prognosis of ICC. Further studies focusing on these miRNAs may shed light on the mechanisms associated with ICC pathogenesis and progression." -tissue_expression_ns hsa-mir-675 Intrahepatic Cholangiocarcinoma 25880914 "In this study, a 30-miRNA signature for distinguishing ICC from NIBD, and a 3-miRNA signature for evaluating prognosis of ICC were established, which might be able to serve as biomarkers for prognosis of ICC. Further studies focusing on these miRNAs may shed light on the mechanisms associated with ICC pathogenesis and progression." -tissue_expression_ns hsa-mir-155 Respiratory Syncytial Virus Pneumonia 25884957 microRNA expression in nasal epithelium cytology brushings of RSV-positive infants shows a distinct profile of immune-associated miRNA.miR-125a has important functions within NF-¦ÊB signaling and macrophage function. The lack of downregulation of miR-125a and miR-429 in severe disease may help explain differences in disease manifestations on infection with RSV. -tissue_expression_ns hsa-mir-16 Respiratory Syncytial Virus Pneumonia 25884957 microRNA expression in nasal epithelium cytology brushings of RSV-positive infants shows a distinct profile of immune-associated miRNA.miR-125a has important functions within NF-¦ÊB signaling and macrophage function. The lack of downregulation of miR-125a and miR-429 in severe disease may help explain differences in disease manifestations on infection with RSV. -tissue_expression_ns hsa-mir-203a Respiratory Syncytial Virus Pneumonia 25884957 microRNA expression in nasal epithelium cytology brushings of RSV-positive infants shows a distinct profile of immune-associated miRNA.miR-125a has important functions within NF-¦ÊB signaling and macrophage function. The lack of downregulation of miR-125a and miR-429 in severe disease may help explain differences in disease manifestations on infection with RSV. -tissue_expression_ns hsa-mir-27b Respiratory Syncytial Virus Pneumonia 25884957 microRNA expression in nasal epithelium cytology brushings of RSV-positive infants shows a distinct profile of immune-associated miRNA.miR-125a has important functions within NF-¦ÊB signaling and macrophage function. The lack of downregulation of miR-125a and miR-429 in severe disease may help explain differences in disease manifestations on infection with RSV. -tissue_expression_ns hsa-mir-29c Respiratory Syncytial Virus Pneumonia 25884957 microRNA expression in nasal epithelium cytology brushings of RSV-positive infants shows a distinct profile of immune-associated miRNA.miR-125a has important functions within NF-¦ÊB signaling and macrophage function. The lack of downregulation of miR-125a and miR-429 in severe disease may help explain differences in disease manifestations on infection with RSV. -tissue_expression_ns hsa-mir-31 Respiratory Syncytial Virus Pneumonia 25884957 microRNA expression in nasal epithelium cytology brushings of RSV-positive infants shows a distinct profile of immune-associated miRNA.miR-125a has important functions within NF-¦ÊB signaling and macrophage function. The lack of downregulation of miR-125a and miR-429 in severe disease may help explain differences in disease manifestations on infection with RSV. -tissue_expression_ns hsa-mir-34b Respiratory Syncytial Virus Pneumonia 25884957 microRNA expression in nasal epithelium cytology brushings of RSV-positive infants shows a distinct profile of immune-associated miRNA.miR-125a has important functions within NF-¦ÊB signaling and macrophage function. The lack of downregulation of miR-125a and miR-429 in severe disease may help explain differences in disease manifestations on infection with RSV. -tissue_expression_ns hsa-mir-34c Respiratory Syncytial Virus Pneumonia 25884957 microRNA expression in nasal epithelium cytology brushings of RSV-positive infants shows a distinct profile of immune-associated miRNA.miR-125a has important functions within NF-¦ÊB signaling and macrophage function. The lack of downregulation of miR-125a and miR-429 in severe disease may help explain differences in disease manifestations on infection with RSV. -tissue_expression_ns hsa-mir-125b Breast Neoplasms 25886191 We were able to demonstrate for the first time the feasibility to detect distinct BC-dependent urinary miRNA profiles. The expression levels of four urinary miRNAs were specifically altered in our cohort of BC patients compared to healthy controls. This distinct pattern offers the possibility for a specific discrimination between healthy women and primary BC patients. This sustains the potential role of urinary miRNAs as non-invasive innovative urine-based biomarkers for BC detection. -tissue_expression_ns hsa-mir-155 Breast Neoplasms 25886191 We were able to demonstrate for the first time the feasibility to detect distinct BC-dependent urinary miRNA profiles. The expression levels of four urinary miRNAs were specifically altered in our cohort of BC patients compared to healthy controls. This distinct pattern offers the possibility for a specific discrimination between healthy women and primary BC patients. This sustains the potential role of urinary miRNAs as non-invasive innovative urine-based biomarkers for BC detection. -tissue_expression_ns hsa-mir-195 Breast Neoplasms 25886191 We were able to demonstrate for the first time the feasibility to detect distinct BC-dependent urinary miRNA profiles. The expression levels of four urinary miRNAs were specifically altered in our cohort of BC patients compared to healthy controls. This distinct pattern offers the possibility for a specific discrimination between healthy women and primary BC patients. This sustains the potential role of urinary miRNAs as non-invasive innovative urine-based biomarkers for BC detection. -tissue_expression_ns hsa-mir-200b Breast Neoplasms 25886191 We were able to demonstrate for the first time the feasibility to detect distinct BC-dependent urinary miRNA profiles. The expression levels of four urinary miRNAs were specifically altered in our cohort of BC patients compared to healthy controls. This distinct pattern offers the possibility for a specific discrimination between healthy women and primary BC patients. This sustains the potential role of urinary miRNAs as non-invasive innovative urine-based biomarkers for BC detection. -tissue_expression_ns hsa-mir-200c Breast Neoplasms 25886191 We were able to demonstrate for the first time the feasibility to detect distinct BC-dependent urinary miRNA profiles. The expression levels of four urinary miRNAs were specifically altered in our cohort of BC patients compared to healthy controls. This distinct pattern offers the possibility for a specific discrimination between healthy women and primary BC patients. This sustains the potential role of urinary miRNAs as non-invasive innovative urine-based biomarkers for BC detection. -tissue_expression_ns hsa-mir-21 Breast Neoplasms 25886191 We were able to demonstrate for the first time the feasibility to detect distinct BC-dependent urinary miRNA profiles. The expression levels of four urinary miRNAs were specifically altered in our cohort of BC patients compared to healthy controls. This distinct pattern offers the possibility for a specific discrimination between healthy women and primary BC patients. This sustains the potential role of urinary miRNAs as non-invasive innovative urine-based biomarkers for BC detection. -tissue_expression_ns hsa-mir-34a Breast Neoplasms 25886191 We were able to demonstrate for the first time the feasibility to detect distinct BC-dependent urinary miRNA profiles. The expression levels of four urinary miRNAs were specifically altered in our cohort of BC patients compared to healthy controls. This distinct pattern offers the possibility for a specific discrimination between healthy women and primary BC patients. This sustains the potential role of urinary miRNAs as non-invasive innovative urine-based biomarkers for BC detection. -tissue_expression_ns hsa-mir-375 Breast Neoplasms 25886191 We were able to demonstrate for the first time the feasibility to detect distinct BC-dependent urinary miRNA profiles. The expression levels of four urinary miRNAs were specifically altered in our cohort of BC patients compared to healthy controls. This distinct pattern offers the possibility for a specific discrimination between healthy women and primary BC patients. This sustains the potential role of urinary miRNAs as non-invasive innovative urine-based biomarkers for BC detection. -tissue_expression_ns hsa-mir-451 Breast Neoplasms 25886191 We were able to demonstrate for the first time the feasibility to detect distinct BC-dependent urinary miRNA profiles. The expression levels of four urinary miRNAs were specifically altered in our cohort of BC patients compared to healthy controls. This distinct pattern offers the possibility for a specific discrimination between healthy women and primary BC patients. This sustains the potential role of urinary miRNAs as non-invasive innovative urine-based biomarkers for BC detection. -tissue_expression_ns hsa-mir-155 Liposarcoma 25888631 Deregulation of dicer and mir-155 expression in liposarcoma. -tissue_expression_ns hsa-mir-29a Gastric Neoplasms 25889078 Our preliminary results suggest that altered expression of miR-29a-3p is involved in gastric cancer process. The present study provides the first insight into the specific role of miR-29a-3p in gastric carcinogenesis. -tissue_expression_ns hsa-mir-145 Colorectal Carcinoma 25896668 "MiRNA-145 and miRNA-378* are potential biomarkers for early detection of CRC, which may help in diagnosing CRC in early period." -tissue_expression_ns hsa-mir-378 Colorectal Carcinoma 25896668 "MiRNA-145 and miRNA-378* are potential biomarkers for early detection of CRC, which may help in diagnosing CRC in early period." -tissue_expression_ns hsa-mir-198 "Adenocarcinoma, Pancreatic Ductal" 25908274 Our data suggest that altered expression of examined microRNAs is related to neoplastic transformation and progression of the disease and these microRNAs could serve as diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma. -tissue_expression_ns hsa-mir-198 Chronic Pancreatitis 25908274 Our data suggest that altered expression of examined microRNAs is related to neoplastic transformation and progression of the disease and these microRNAs could serve as diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma. -tissue_expression_ns hsa-mir-21 "Adenocarcinoma, Pancreatic Ductal" 25908274 Our data suggest that altered expression of examined microRNAs is related to neoplastic transformation and progression of the disease and these microRNAs could serve as diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma. -tissue_expression_ns hsa-mir-21 Chronic Pancreatitis 25908274 Our data suggest that altered expression of examined microRNAs is related to neoplastic transformation and progression of the disease and these microRNAs could serve as diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma. -tissue_expression_ns hsa-mir-217 "Adenocarcinoma, Pancreatic Ductal" 25908274 Our data suggest that altered expression of examined microRNAs is related to neoplastic transformation and progression of the disease and these microRNAs could serve as diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma. -tissue_expression_ns hsa-mir-217 Chronic Pancreatitis 25908274 Our data suggest that altered expression of examined microRNAs is related to neoplastic transformation and progression of the disease and these microRNAs could serve as diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma. -tissue_expression_ns hsa-mir-34a "Adenocarcinoma, Pancreatic Ductal" 25908274 Our data suggest that altered expression of examined microRNAs is related to neoplastic transformation and progression of the disease and these microRNAs could serve as diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma. -tissue_expression_ns hsa-mir-34a Chronic Pancreatitis 25908274 Our data suggest that altered expression of examined microRNAs is related to neoplastic transformation and progression of the disease and these microRNAs could serve as diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma. -tissue_expression_ns hsa-mir-106b "Carcinoma, Hepatocellular" 25916067 "A total of 54 differentially expressed miRNAs were identified, in which there were 13 miRNAs published to be related to HCC." -tissue_expression_ns hsa-mir-205 Lung Neoplasms 25917317 MiR-205 and miR-218 expression is associated with carboplatin chemoresistance and regulation of apoptosis via Mcl-1 and Survivin in lung cancer cells. -tissue_expression_ns hsa-mir-218 Lung Neoplasms 25917317 MiR-205 and miR-218 expression is associated with carboplatin chemoresistance and regulation of apoptosis via Mcl-1 and Survivin in lung cancer cells. -tissue_expression_ns hsa-mir-10a "Carcinoma, Cervical" 25920605 This meta-analysis has identified several miRNAs whose expression correlates reliably with cervical cancer. These should be probed in further studies to explore their potential as diagnostic biomarkers. -tissue_expression_ns hsa-mir-141 "Carcinoma, Cervical" 25920605 This meta-analysis has identified several miRNAs whose expression correlates reliably with cervical cancer. These should be probed in further studies to explore their potential as diagnostic biomarkers. -tissue_expression_ns hsa-mir-143 "Carcinoma, Cervical" 25920605 This meta-analysis has identified several miRNAs whose expression correlates reliably with cervical cancer. These should be probed in further studies to explore their potential as diagnostic biomarkers. -tissue_expression_ns hsa-mir-145 "Carcinoma, Cervical" 25920605 This meta-analysis has identified several miRNAs whose expression correlates reliably with cervical cancer. These should be probed in further studies to explore their potential as diagnostic biomarkers. -tissue_expression_ns hsa-mir-15b "Carcinoma, Cervical" 25920605 This meta-analysis has identified several miRNAs whose expression correlates reliably with cervical cancer. These should be probed in further studies to explore their potential as diagnostic biomarkers. -tissue_expression_ns hsa-mir-200a "Carcinoma, Cervical" 25920605 This meta-analysis has identified several miRNAs whose expression correlates reliably with cervical cancer. These should be probed in further studies to explore their potential as diagnostic biomarkers. -tissue_expression_ns hsa-mir-203 "Carcinoma, Cervical" 25920605 This meta-analysis has identified several miRNAs whose expression correlates reliably with cervical cancer. These should be probed in further studies to explore their potential as diagnostic biomarkers. -tissue_expression_ns hsa-mir-20a "Carcinoma, Cervical" 25920605 This meta-analysis has identified several miRNAs whose expression correlates reliably with cervical cancer. These should be probed in further studies to explore their potential as diagnostic biomarkers. -tissue_expression_ns hsa-mir-20b "Carcinoma, Cervical" 25920605 This meta-analysis has identified several miRNAs whose expression correlates reliably with cervical cancer. These should be probed in further studies to explore their potential as diagnostic biomarkers. -tissue_expression_ns hsa-mir-224 "Carcinoma, Cervical" 25920605 This meta-analysis has identified several miRNAs whose expression correlates reliably with cervical cancer. These should be probed in further studies to explore their potential as diagnostic biomarkers. -tissue_expression_ns hsa-mir-148 "Adenocarcinoma, Esophageal" 25928282 "Our data suggest that altered expression of miR-21, miR-29c, miR-148 and miR-203 are related to neoplastic transformation and progression of the disease and these microRNAs could serve as a potential diagnostic and prognostic biomarkers in esophageal cancer." -tissue_expression_ns hsa-mir-148 "Squamous Cell Carcinoma, Esophageal" 25928282 "Our data suggest that altered expression of miR-21, miR-29c, miR-148 and miR-203 are related to neoplastic transformation and progression of the disease and these microRNAs could serve as a potential diagnostic and prognostic biomarkers in esophageal cancer." -tissue_expression_ns hsa-mir-203 "Adenocarcinoma, Esophageal" 25928282 "Our data suggest that altered expression of miR-21, miR-29c, miR-148 and miR-203 are related to neoplastic transformation and progression of the disease and these microRNAs could serve as a potential diagnostic and prognostic biomarkers in esophageal cancer." -tissue_expression_ns hsa-mir-203 "Squamous Cell Carcinoma, Esophageal" 25928282 "Our data suggest that altered expression of miR-21, miR-29c, miR-148 and miR-203 are related to neoplastic transformation and progression of the disease and these microRNAs could serve as a potential diagnostic and prognostic biomarkers in esophageal cancer." -tissue_expression_ns hsa-mir-21 "Adenocarcinoma, Esophageal" 25928282 "Our data suggest that altered expression of miR-21, miR-29c, miR-148 and miR-203 are related to neoplastic transformation and progression of the disease and these microRNAs could serve as a potential diagnostic and prognostic biomarkers in esophageal cancer." -tissue_expression_ns hsa-mir-21 "Squamous Cell Carcinoma, Esophageal" 25928282 "Our data suggest that altered expression of miR-21, miR-29c, miR-148 and miR-203 are related to neoplastic transformation and progression of the disease and these microRNAs could serve as a potential diagnostic and prognostic biomarkers in esophageal cancer." -tissue_expression_ns hsa-mir-29c "Adenocarcinoma, Esophageal" 25928282 "Our data suggest that altered expression of miR-21, miR-29c, miR-148 and miR-203 are related to neoplastic transformation and progression of the disease and these microRNAs could serve as a potential diagnostic and prognostic biomarkers in esophageal cancer." -tissue_expression_ns hsa-mir-29c "Squamous Cell Carcinoma, Esophageal" 25928282 "Our data suggest that altered expression of miR-21, miR-29c, miR-148 and miR-203 are related to neoplastic transformation and progression of the disease and these microRNAs could serve as a potential diagnostic and prognostic biomarkers in esophageal cancer." -tissue_expression_ns hsa-mir-29a "Carcinoma, Renal Cell, Clear-Cell" 25938468 "This study identified 11 commonly dysregulated miRNAs in ccRCC,three of which (miR-199a-5p, miR-22 and miR-429) may represent key miRNAs involved in the pathogenesis of ccRCC. Further studies suggested that miR-199a-5p plays an important role in inhibition of cell invasion of ccRCC cells by suppressing expression of TGFBR1 and JunB." -tissue_expression_ns hsa-mir-429 "Carcinoma, Renal Cell, Clear-Cell" 25938468 "This study identified 11 commonly dysregulated miRNAs in ccRCC,three of which (miR-199a-5p, miR-22 and miR-429) may represent key miRNAs involved in the pathogenesis of ccRCC. Further studies suggested that miR-199a-5p plays an important role in inhibition of cell invasion of ccRCC cells by suppressing expression of TGFBR1 and JunB." -tissue_expression_ns hsa-mir-452 "Carcinoma, Renal Cell, Clear-Cell" 25938468 "This study identified 11 commonly dysregulated miRNAs in ccRCC,three of which (miR-199a-5p, miR-22 and miR-429) may represent key miRNAs involved in the pathogenesis of ccRCC. Further studies suggested that miR-199a-5p plays an important role in inhibition of cell invasion of ccRCC cells by suppressing expression of TGFBR1 and JunB." -tissue_expression_ns hsa-mir-487a "Carcinoma, Renal Cell, Clear-Cell" 25938468 "This study identified 11 commonly dysregulated miRNAs in ccRCC,three of which (miR-199a-5p, miR-22 and miR-429) may represent key miRNAs involved in the pathogenesis of ccRCC. Further studies suggested that miR-199a-5p plays an important role in inhibition of cell invasion of ccRCC cells by suppressing expression of TGFBR1 and JunB." -tissue_expression_ns hsa-mir-491 "Carcinoma, Renal Cell, Clear-Cell" 25938468 "This study identified 11 commonly dysregulated miRNAs in ccRCC,three of which (miR-199a-5p, miR-22 and miR-429) may represent key miRNAs involved in the pathogenesis of ccRCC. Further studies suggested that miR-199a-5p plays an important role in inhibition of cell invasion of ccRCC cells by suppressing expression of TGFBR1 and JunB." -tissue_expression_ns hsa-mir-532 "Carcinoma, Renal Cell, Clear-Cell" 25938468 "This study identified 11 commonly dysregulated miRNAs in ccRCC,three of which (miR-199a-5p, miR-22 and miR-429) may represent key miRNAs involved in the pathogenesis of ccRCC. Further studies suggested that miR-199a-5p plays an important role in inhibition of cell invasion of ccRCC cells by suppressing expression of TGFBR1 and JunB." -tissue_expression_ns hsa-mir-21 Rectal Neoplasms 25953218 MicroRNA-21 expression efficiently predicts preoperative chemoradiotherapy pathological response in locally advanced rectal cancer. -tissue_expression_ns hsa-mir-34a Glioma 25953448 "The top 20 potential miRNAs including MIR-124A, MIR-34A and MIR-34C were screened for a constructing gene-miRNA interaction network." -tissue_expression_ns hsa-mir-4489 Glioma 25954994 The dysregulated miRNAs identified in the present study contribute to the tumorigenesis and malignant progression of gliomas and may serve as useful markers for advanced glioma pathological grading and prognosis. -tissue_expression_ns hsa-mir-196b "Carcinoma, Ovarian" 25964536 "Based on our data, dysregulation of microRNA expression was associated with the recurrence of EOC. Moreover, significantly over- and down-regulated microRNAs can be useful biomarkers for the prediction of recurrence in EOC." -tissue_expression_ns hsa-mir-19b "Carcinoma, Ovarian" 25964536 "Based on our data, dysregulation of microRNA expression was associated with the recurrence of EOC. Moreover, significantly over- and down-regulated microRNAs can be useful biomarkers for the prediction of recurrence in EOC." -tissue_expression_ns hsa-mir-3198 "Carcinoma, Ovarian" 25964536 "Based on our data, dysregulation of microRNA expression was associated with the recurrence of EOC. Moreover, significantly over- and down-regulated microRNAs can be useful biomarkers for the prediction of recurrence in EOC." -tissue_expression_ns hsa-mir-3201 "Carcinoma, Ovarian" 25964536 "Based on our data, dysregulation of microRNA expression was associated with the recurrence of EOC. Moreover, significantly over- and down-regulated microRNAs can be useful biomarkers for the prediction of recurrence in EOC." -tissue_expression_ns hsa-mir-3613 "Carcinoma, Ovarian" 25964536 "Based on our data, dysregulation of microRNA expression was associated with the recurrence of EOC. Moreover, significantly over- and down-regulated microRNAs can be useful biomarkers for the prediction of recurrence in EOC." -tissue_expression_ns hsa-mir-551b "Carcinoma, Ovarian" 25964536 "Based on our data, dysregulation of microRNA expression was associated with the recurrence of EOC. Moreover, significantly over- and down-regulated microRNAs can be useful biomarkers for the prediction of recurrence in EOC." -tissue_expression_ns hsa-mir-7515 "Carcinoma, Ovarian" 25964536 "Based on our data, dysregulation of microRNA expression was associated with the recurrence of EOC. Moreover, significantly over- and down-regulated microRNAs can be useful biomarkers for the prediction of recurrence in EOC." -tissue_expression_ns hsa-mir-8084 "Carcinoma, Ovarian" 25964536 "Based on our data, dysregulation of microRNA expression was associated with the recurrence of EOC. Moreover, significantly over- and down-regulated microRNAs can be useful biomarkers for the prediction of recurrence in EOC." -tissue_expression_ns hsa-mir-155 Cardiovascular Diseases [unspecific] 25978529 microRNA expression patterns have a low diagnostic potential clinically in discriminating DCD liver quality and outcome. -tissue_expression_ns hsa-mir-22 Cardiovascular Diseases [unspecific] 25978529 microRNA expression patterns have a low diagnostic potential clinically in discriminating DCD liver quality and outcome. -tissue_expression_ns hsa-mir-940 Cardiovascular Diseases [unspecific] 25978529 microRNA expression patterns have a low diagnostic potential clinically in discriminating DCD liver quality and outcome. -tissue_expression_ns hsa-mir-191 "Carcinoma, Renal Cell, Chromophobe" 25981392 "mir-191, mir-19a, mir-210, and mir-425 miRNAs are expressed differentially in chRCC, and unique expression of miRNAs is associated with the progression and prognosis of chRCC." -tissue_expression_ns hsa-mir-19a "Carcinoma, Renal Cell, Chromophobe" 25981392 "mir-191, mir-19a, mir-210, and mir-425 miRNAs are expressed differentially in chRCC, and unique expression of miRNAs is associated with the progression and prognosis of chRCC." -tissue_expression_ns hsa-mir-210 "Carcinoma, Renal Cell, Chromophobe" 25981392 "mir-191, mir-19a, mir-210, and mir-425 miRNAs are expressed differentially in chRCC, and unique expression of miRNAs is associated with the progression and prognosis of chRCC." -tissue_expression_ns hsa-mir-425 "Carcinoma, Renal Cell, Chromophobe" 25981392 "mir-191, mir-19a, mir-210, and mir-425 miRNAs are expressed differentially in chRCC, and unique expression of miRNAs is associated with the progression and prognosis of chRCC." -tissue_expression_ns hsa-let-7c "Carcinoma, Bladder" 25990459 this study identified the specific miRNAs associated with the progression and aggressiveness of MIBC and a four-miRNA signature as a promising prognostic parameter of MIBC. -tissue_expression_ns hsa-mir-125b-1 "Carcinoma, Bladder" 25990459 this study identified the specific miRNAs associated with the progression and aggressiveness of MIBC and a four-miRNA signature as a promising prognostic parameter of MIBC. -tissue_expression_ns hsa-mir-193a "Carcinoma, Bladder" 25990459 this study identified the specific miRNAs associated with the progression and aggressiveness of MIBC and a four-miRNA signature as a promising prognostic parameter of MIBC. -tissue_expression_ns hsa-mir-99a "Carcinoma, Bladder" 25990459 this study identified the specific miRNAs associated with the progression and aggressiveness of MIBC and a four-miRNA signature as a promising prognostic parameter of MIBC. -tissue_expression_ns hsa-mir-373 Neoplasms [unspecific] 25990556 "Deregulation of miR-373 has been demonstrated in a number of cancers, whether it acts as an oncogene or a tumor suppressor, however, seems to be context dependent. In this review, we focus on the diverse functions of miR-373 and its implication in cancers." -tissue_expression_ns hsa-let-7 Neoplasms [unspecific] 25998712 "together with the recent identification of novel miRNA regulatory factors and pathways, highlights the importance of miRNA dysregulation in cancer." -tissue_expression_ns hsa-mir-15 Neoplasms [unspecific] 25998712 "together with the recent identification of novel miRNA regulatory factors and pathways, highlights the importance of miRNA dysregulation in cancer." -tissue_expression_ns hsa-mir-16 Neoplasms [unspecific] 25998712 "together with the recent identification of novel miRNA regulatory factors and pathways, highlights the importance of miRNA dysregulation in cancer." -tissue_expression_ns hsa-mir-222 "Adenocarcinoma, Pancreatic Ductal" 26002251 "we found significant adjusted HRs for poor OS for high miR-155, high miR-203, and low miR-34a; and unadjusted HRs for high miR-222 and high miR-10b." -tissue_expression_ns hsa-mir-1 Colorectal Carcinoma 26045793 The potential value of miR-1 and miR-374b as biomarkers for colorectal cancer. -tissue_expression_ns hsa-mir-191 Acute Myocardial Infarction 26046358 "This study highlights the stability of miRNAs after death and long-term fixation, validating their use as reliable biomarkers for AMI during postmortem examination." -tissue_expression_ns hsa-mir-26b Acute Myocardial Infarction 26046358 "This study highlights the stability of miRNAs after death and long-term fixation, validating their use as reliable biomarkers for AMI during postmortem examination." -tissue_expression_ns hsa-mir-30a "Carcinoma, Thyroid, Papillary" 26047355 The results of this study suggest that miR-30a-5p might be a novel diagnostic marker candidate in PTC. Further studies are required to investigate this possibility. -tissue_expression_ns hsa-mir-126 "Carcinoma, Breast, Triple Negative" 26062749 "This study provides strong evidence that the expression levels of miR-374b-5p, miR-27b-3p, miR-126-3p, and miR-218-5p in tumor tissues predict TNBC outcomes." -tissue_expression_ns hsa-mir-218 "Carcinoma, Breast, Triple Negative" 26062749 "This study provides strong evidence that the expression levels of miR-374b-5p, miR-27b-3p, miR-126-3p, and miR-218-5p in tumor tissues predict TNBC outcomes." -tissue_expression_ns hsa-mir-27b "Carcinoma, Breast, Triple Negative" 26062749 "This study provides strong evidence that the expression levels of miR-374b-5p, miR-27b-3p, miR-126-3p, and miR-218-5p in tumor tissues predict TNBC outcomes." -tissue_expression_ns hsa-mir-374b "Carcinoma, Breast, Triple Negative" 26062749 "This study provides strong evidence that the expression levels of miR-374b-5p, miR-27b-3p, miR-126-3p, and miR-218-5p in tumor tissues predict TNBC outcomes." -tissue_expression_ns hsa-mir-31 "Squamous Cell Carcinoma, Oral" 26104160 "MiR-31 and miR-130b, known to inhibit several steps in the metastatic process, were over-expressed in non-metastatic samples and the expression of miR-130b was confirmed in plasma of patients showing no metastasis." -tissue_expression_ns hsa-mir-34a "Adenocarcinoma, Lung" 26104764 The expression of microRNA-34a is inversely correlated with c-MET and CDK6 and has a prognostic significance in lung adenocarcinoma patients. -tissue_expression_ns hsa-let-7a Breast Neoplasms 26130254 "Relative levels of let-7a, miR-17, miR-27b, miR-125a, miR-125b and miR-206 as potential molecular markers to evaluate grade, receptor status and molecular type in breast cancer." -tissue_expression_ns hsa-mir-130b Breast Neoplasms 26152113 Comparative microRNA profiling of sporadic and BRCA1 associated basal-like breast cancers -tissue_expression_ns hsa-mir-149 Breast Neoplasms 26152113 Comparative microRNA profiling of sporadic and BRCA2 associated basal-like breast cancers -tissue_expression_ns hsa-mir-190b Breast Neoplasms 26152113 Comparative microRNA profiling of sporadic and BRCA3 associated basal-like breast cancers -tissue_expression_ns hsa-mir-198 Breast Neoplasms 26152113 Comparative microRNA profiling of sporadic and BRCA4 associated basal-like breast cancers -tissue_expression_ns hsa-mir-218 Breast Neoplasms 26152113 Comparative microRNA profiling of sporadic and BRCA5 associated basal-like breast cancers -tissue_expression_ns hsa-mir-374b Breast Neoplasms 26152113 Comparative microRNA profiling of sporadic and BRCA7 associated basal-like breast cancers -tissue_expression_ns hsa-mir-590 Breast Neoplasms 26152113 Comparative microRNA profiling of sporadic and BRCA6 associated basal-like breast cancers -tissue_expression_ns hsa-mir-892a Breast Neoplasms 26152113 Comparative microRNA profiling of sporadic and BRCA8 associated basal-like breast cancers -tissue_expression_ns hsa-mir-196b Crohn Disease 26164662 "We found a suite of miRNAs, including miR-31-5p, miR-215, miR-223-3p, miR-196b-5p, and miR-203 that stratify patients with CD according to disease behavior independent of the effect of inflammation." -tissue_expression_ns hsa-mir-203 Crohn Disease 26164662 "We found a suite of miRNAs, including miR-31-5p, miR-215, miR-223-3p, miR-196b-5p, and miR-203 that stratify patients with CD according to disease behavior independent of the effect of inflammation." -tissue_expression_ns hsa-mir-1-2 Gastric Neoplasms 26168960 "mir-17, mir-133b, mir-133a-2, and mir-1-2 appear to be a potential novel predictor of tumor stage and preoperative and intraoperative diagnosis." -tissue_expression_ns hsa-mir-133a-2 Gastric Neoplasms 26168960 "mir-17, mir-133b, mir-133a-2, and mir-1-2 appear to be a potential novel predictor of tumor stage and preoperative and intraoperative diagnosis." -tissue_expression_ns hsa-mir-133b Gastric Neoplasms 26168960 "mir-17, mir-133b, mir-133a-2, and mir-1-2 appear to be a potential novel predictor of tumor stage and preoperative and intraoperative diagnosis." -tissue_expression_ns hsa-mir-17 Gastric Neoplasms 26168960 "mir-17, mir-133b, mir-133a-2, and mir-1-2 appear to be a potential novel predictor of tumor stage and preoperative and intraoperative diagnosis." -tissue_expression_ns hsa-mir-23a "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 26175945 MiR-21/miR-375 ratio is an independent prognostic factor in patients with laryngeal squamous cell carcinoma. -tissue_expression_ns hsa-mir-126 Osteosarcoma 26194657 Tissue microRNA-126 expression level predicts outcome in human osteosarcoma. -tissue_expression_ns hsa-mir-148a Breast Neoplasms 26199650 "Based on the results obtained in the last decade, some miRNAs are emerging as biomarkers of BC for diagnosis (i.e., miR-9, miR-10b, and miR-17-5p), prognosis (i.e., miR-148a and miR-335)" -tissue_expression_ns hsa-mir-122 "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-125a "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-129 "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-133b "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-142 "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-192 "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-194 "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-195 "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-198 "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-199a "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-20 "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-200a "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-215 "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-223 "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-224 "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-24 "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-25 "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-26b "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-27a "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-29a "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-29b "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-320 "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-369 "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-491 "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-512 "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-522 "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-542 "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-576 "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-651 "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-92 "Carcinoma, Hepatocellular" 26229398 "In summary, all the reported results suggest that differences in miRNA expression exist between HCV-related and HCV-negative NHLs, and further studies will be useful to ascertain if miRNAs are involved in the pathogenesis of HCV-related lymphomas and whether they can be used as biomarkers." -tissue_expression_ns hsa-mir-130a "Carcinoma, Hepatocellular" 26231037 Systematic and integrative analysis of published datesets that compared the miRNA expression profiles between hepatocellular carcinoma (HCC) tissue and paired adjacent noncancerous liver tissue was performed to determine candidate HCC associated miRNAs. -tissue_expression_ns hsa-mir-21 "Carcinoma, Hepatocellular" 26231037 Systematic and integrative analysis of published datesets that compared the miRNA expression profiles between hepatocellular carcinoma (HCC) tissue and paired adjacent noncancerous liver tissue was performed to determine candidate HCC associated miRNAs. -tissue_expression_ns hsa-mir-214 "Carcinoma, Hepatocellular" 26231037 Systematic and integrative analysis of published datesets that compared the miRNA expression profiles between hepatocellular carcinoma (HCC) tissue and paired adjacent noncancerous liver tissue was performed to determine candidate HCC associated miRNAs. -tissue_expression_ns hsa-mir-221 "Carcinoma, Hepatocellular" 26231037 Systematic and integrative analysis of published datesets that compared the miRNA expression profiles between hepatocellular carcinoma (HCC) tissue and paired adjacent noncancerous liver tissue was performed to determine candidate HCC associated miRNAs. -tissue_expression_ns hsa-mir-186 Glioma 26231038 CRNDE affects the malignant biological characteristics of human glioma stem cells by negatively regulating miR-186. -tissue_expression_ns hsa-mir-15a "Carcinoma, Thyroid, Papillary" 26252081 "We found that the area under the curve (AUC) values of 8 miRNAs (miR-106a, miR-15a, miR-30a, miR-30b, miR-20a, miR-20b, miR-30d and miR-30e)" -tissue_expression_ns hsa-mir-20a "Carcinoma, Thyroid, Papillary" 26252081 "We found that the area under the curve (AUC) values of 8 miRNAs (miR-106a, miR-15a, miR-30a, miR-30b, miR-20a, miR-20b, miR-30d and miR-30e)" -tissue_expression_ns hsa-mir-30e "Carcinoma, Thyroid, Papillary" 26252081 "We found that the area under the curve (AUC) values of 8 miRNAs (miR-106a, miR-15a, miR-30a, miR-30b, miR-20a, miR-20b, miR-30d and miR-30e)" -tissue_expression_ns hsa-mir-320 Melanoma 26264058 "hsa-miR-519, ""hsa-miR-431"" and ""hsa-miR-320c"" are possible novel predictions for renal cancer, lung cancer and melanoma, respectively." -tissue_expression_ns hsa-mir-182 Melanoma 26273328 Clinical analyses demonstrated the link of miR-182 expression to poor prognosis in cancer patients. -tissue_expression_ns hsa-mir-4793 Necrotizing Enterocolitis 26274503 "The robust response of miRNA dysregulation in NEC and SIP, and concerted involvement of specific miRNAs in the molecular networks indicated their crucial roles in mucosa integrity and disease pathophysiology." -tissue_expression_ns hsa-mir-1290 Necrotizing Enterocolitis 26274503 "The robust response of miRNA dysregulation in NEC and SIP, and concerted involvement of specific miRNAs in the molecular networks indicated their crucial roles in mucosa integrity and disease pathophysiology." -tissue_expression_ns hsa-mir-194 Necrotizing Enterocolitis 26274503 "The robust response of miRNA dysregulation in NEC and SIP, and concerted involvement of specific miRNAs in the molecular networks indicated their crucial roles in mucosa integrity and disease pathophysiology." -tissue_expression_ns hsa-mir-203 Necrotizing Enterocolitis 26274503 "The robust response of miRNA dysregulation in NEC and SIP, and concerted involvement of specific miRNAs in the molecular networks indicated their crucial roles in mucosa integrity and disease pathophysiology." -tissue_expression_ns hsa-mir-21 Necrotizing Enterocolitis 26274503 "The robust response of miRNA dysregulation in NEC and SIP, and concerted involvement of specific miRNAs in the molecular networks indicated their crucial roles in mucosa integrity and disease pathophysiology." -tissue_expression_ns hsa-mir-31 Necrotizing Enterocolitis 26274503 "The robust response of miRNA dysregulation in NEC and SIP, and concerted involvement of specific miRNAs in the molecular networks indicated their crucial roles in mucosa integrity and disease pathophysiology." -tissue_expression_ns hsa-mir-431 Necrotizing Enterocolitis 26274503 "The robust response of miRNA dysregulation in NEC and SIP, and concerted involvement of specific miRNAs in the molecular networks indicated their crucial roles in mucosa integrity and disease pathophysiology." -tissue_expression_ns hsa-mir-451 Necrotizing Enterocolitis 26274503 "The robust response of miRNA dysregulation in NEC and SIP, and concerted involvement of specific miRNAs in the molecular networks indicated their crucial roles in mucosa integrity and disease pathophysiology." -tissue_expression_ns hsa-mir-23b "Carcinoma, Adenoid Cystic" 26293217 Expression of miR-23b and miR-27b differed between normal breast and normal salivary gland tissue -tissue_expression_ns hsa-mir-22 Neoplasms [unspecific] 26295583 Genome Wide Expression Profiling of Cancer Cell Lines Cultured in Microgravity Reveals Significant Dysregulation of Cell Cycle and MicroRNA Gene Networks. -tissue_expression_ns hsa-mir-16 Neoplasms [unspecific] 26299954 Genome-wide analysis of microRNA and mRNA expression signatures in cancer. -tissue_expression_ns hsa-mir-191 Neoplasms [unspecific] 26299954 Genome-wide analysis of microRNA and mRNA expression signatures in cancer. -tissue_expression_ns hsa-mir-93 Neoplasms [unspecific] 26299954 Genome-wide analysis of microRNA and mRNA expression signatures in cancer. -tissue_expression_ns hsa-mir-31 Inflammation 26303911 "We identified three miRNAs, miR-497, miR-351 and miR-31, that are candidate master regulators of genes associated with neutrophil recruitment." -tissue_expression_ns hsa-mir-16 Endometriosis 26307093 Peritoneal fluid modifies the microRNA expression profile in endometrial and endometriotic cells from women with endometriosis. -tissue_expression_ns hsa-mir-29c Endometriosis 26307093 Peritoneal fluid modifies the microRNA expression profile in endometrial and endometriotic cells from women with endometriosis. -tissue_expression_ns hsa-mir-424 Endometriosis 26307093 Peritoneal fluid modifies the microRNA expression profile in endometrial and endometriotic cells from women with endometriosis. -tissue_expression_ns hsa-mir-200c Uterine Corpus Myxoid Leiomyosarcoma 26307392 Malignant tumors of the uterine corpus: molecular background of their origin. -tissue_expression_ns hsa-mir-146b "Carcinoma, Thyroid, Papillary" 26321247 miRNA-222 and miRNA-146b deregulation are commonly associated with cancer recurrence in patients with papillary thyroid carcinoma. -tissue_expression_ns hsa-mir-222 "Carcinoma, Thyroid, Papillary" 26321247 miRNA-222 and miRNA-146b deregulation are commonly associated with cancer recurrence in patients with papillary thyroid carcinoma. -tissue_expression_ns hsa-mir-34b "Carcinoma, Nasopharyngeal" 26330189 Integrated analysis of the differential cellular and EBV miRNA expression profiles in microdissected nasopharyngeal carcinoma and non-cancerous nasopharyngeal tissues. -tissue_expression_ns hsa-mir-1 "Carcinoma, Breast" 26331797 These findings suggest that abnormal miR-1 expression is associated with an aggressive phenotype of breast carcinoma and that miR-1 status is a potent prognostic factor in human breast cancer patients. -tissue_expression_ns hsa-mir-145 Colorectal Carcinoma 26335822 The analysis of microRNAs miR-200C and miR-145 expression in colorectal cancer of different molecular subtypes. -tissue_expression_ns hsa-mir-200C Colorectal Carcinoma 26335822 The analysis of microRNAs miR-200C and miR-145 expression in colorectal cancer of different molecular subtypes. -tissue_expression_ns hsa-mir-21 Choriocarcinoma 26338526 Statistical analysis of a Bayesian classifier based on the expression of miRNAs. -tissue_expression_ns hsa-mir-451 Endometriosis 26370665 Altered expression of microRNA-451 in eutopic endometrium of baboons (Papioanubis) with endometriosis. -tissue_expression_ns hsa-mir-181c "Carcinoma, Urothelial, Upper Tract" 26397152 Differential microRNA expression in aristolochic acid-induced upper urothelial tract cancers ex vivo. -tissue_expression_ns hsa-mir-330 "Carcinoma, Urothelial, Upper Tract" 26397152 Differential microRNA expression in aristolochic acid-induced upper urothelial tract cancers ex vivo. -tissue_expression_ns hsa-mir-3916 "Carcinoma, Urothelial, Upper Tract" 26397152 Differential microRNA expression in aristolochic acid-induced upper urothelial tract cancers ex vivo. -tissue_expression_ns hsa-mir-4274 "Carcinoma, Urothelial, Upper Tract" 26397152 Differential microRNA expression in aristolochic acid-induced upper urothelial tract cancers ex vivo. -tissue_expression_ns hsa-mir-4784 "Carcinoma, Urothelial, Upper Tract" 26397152 Differential microRNA expression in aristolochic acid-induced upper urothelial tract cancers ex vivo. -tissue_expression_ns hsa-mir-4795 "Carcinoma, Urothelial, Upper Tract" 26397152 Differential microRNA expression in aristolochic acid-induced upper urothelial tract cancers ex vivo. -tissue_expression_ns hsa-mir-488 "Carcinoma, Urothelial, Upper Tract" 26397152 Differential microRNA expression in aristolochic acid-induced upper urothelial tract cancers ex vivo. -tissue_expression_ns hsa-mir-203 "Carcinoma, Lung" 26397233 "Cumulatively,our data purport that p53 not only increased Puma expression directly, but that it may also do so through miR-203. Additionally, functional studies revealed that miR-203 overexpression induced apoptosis and inhibited cell invasiveness." -tissue_expression_ns hsa-mir-203 Colon Neoplasms 26397233 "Cumulatively,our data purport that p53 not only increased Puma expression directly, but that it may also do so through miR-203. Additionally, functional studies revealed that miR-203 overexpression induced apoptosis and inhibited cell invasiveness." -tissue_expression_ns hsa-mir-1 Muscular Dystrophy 26398013 "whereas down-regulation of myogenic miRNAs, including miR-1 and miR-206, is associated with inhibition of muscle regeneration." -tissue_expression_ns hsa-mir-125b Neoplasms [unspecific] 26407906 The aberrant expression of miR-125 familyis tightly related to tumorigenesis and tumor development. -tissue_expression_ns hsa-mir-1271 "Carcinoma, Thyroid, Papillary" 26414548 Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations. -tissue_expression_ns hsa-mir-130b "Carcinoma, Thyroid, Papillary" 26414548 Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations. -tissue_expression_ns hsa-mir-135b "Carcinoma, Thyroid, Papillary" 26414548 Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations. -tissue_expression_ns hsa-mir-146b "Carcinoma, Thyroid, Papillary" 26414548 Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations. -tissue_expression_ns hsa-mir-151 "Carcinoma, Thyroid, Papillary" 26414548 Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations. -tissue_expression_ns hsa-mir-181b "Carcinoma, Thyroid, Papillary" 26414548 Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations. -tissue_expression_ns hsa-mir-199b "Carcinoma, Thyroid, Papillary" 26414548 Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations. -tissue_expression_ns hsa-mir-21 "Carcinoma, Thyroid, Papillary" 26414548 Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations. -tissue_expression_ns hsa-mir-221 "Carcinoma, Thyroid, Papillary" 26414548 Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations. -tissue_expression_ns hsa-mir-222 "Carcinoma, Thyroid, Papillary" 26414548 Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations. -tissue_expression_ns hsa-mir-2861 "Carcinoma, Thyroid, Papillary" 26414548 Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations. -tissue_expression_ns hsa-mir-34b "Carcinoma, Thyroid, Papillary" 26414548 Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations. -tissue_expression_ns hsa-mir-451 "Carcinoma, Thyroid, Papillary" 26414548 Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations. -tissue_expression_ns hsa-mir-623 "Carcinoma, Thyroid, Papillary" 26414548 Further studies are needed to investigate whether miRs are independent predictors of aggressive clinicopathologic features before it can be recommended that miR expression levels should be incorporated into the management algorithm for patients with PTC. A well-designed prospective study is needed to assess these potential associations. -tissue_expression_ns hsa-mir-126 Colorectal Carcinoma 26455548 "To conclude, deregulation of miR-126 in colorectal cancer at the tissue and cellular levels as well as its correlation with various clinicopathological parameters confirm the cancer suppressive role of miR-126 in colorectal cancer." -tissue_expression_ns hsa-mir-139 Colorectal Carcinoma 26462034 Clinical value of integrated-signature miRNAs in colorectal cancer: miRNA expression profiling analysis and experimental validation. -tissue_expression_ns hsa-mir-143 Colorectal Carcinoma 26462034 Clinical value of integrated-signature miRNAs in colorectal cancer: miRNA expression profiling analysis and experimental validation. -tissue_expression_ns hsa-mir-145 Colorectal Carcinoma 26462034 Clinical value of integrated-signature miRNAs in colorectal cancer: miRNA expression profiling analysis and experimental validation. -tissue_expression_ns hsa-mir-17 Colorectal Carcinoma 26462034 Clinical value of integrated-signature miRNAs in colorectal cancer: miRNA expression profiling analysis and experimental validation. -tissue_expression_ns hsa-mir-183 Colorectal Carcinoma 26462034 Clinical value of integrated-signature miRNAs in colorectal cancer: miRNA expression profiling analysis and experimental validation. -tissue_expression_ns hsa-mir-195 Colorectal Carcinoma 26462034 Clinical value of integrated-signature miRNAs in colorectal cancer: miRNA expression profiling analysis and experimental validation. -tissue_expression_ns hsa-mir-20a Colorectal Carcinoma 26462034 Clinical value of integrated-signature miRNAs in colorectal cancer: miRNA expression profiling analysis and experimental validation. -tissue_expression_ns hsa-mir-21 Colorectal Carcinoma 26462034 Clinical value of integrated-signature miRNAs in colorectal cancer: miRNA expression profiling analysis and experimental validation. -tissue_expression_ns hsa-mir-378a Colorectal Carcinoma 26462034 Clinical value of integrated-signature miRNAs in colorectal cancer: miRNA expression profiling analysis and experimental validation. -tissue_expression_ns hsa-mir-17 "Carcinoma, Colon" 26465597 "It is concluded that the expression of miR-17, miR-21, and miR-145 changes at early stages of the normal-adenoma-adenocarcinoma sequence. Thus, these microRNAs may play a role in the development of colon cancer." -tissue_expression_ns hsa-mir-18 "Carcinoma, Colon" 26465597 "It is concluded that the expression of miR-17, miR-21, and miR-145 changes at early stages of the normal-adenoma-adenocarcinoma sequence. Thus, these microRNAs may play a role in the development of colon cancer." -tissue_expression_ns hsa-mir-19a "Carcinoma, Colon" 26465597 "It is concluded that the expression of miR-17, miR-21, and miR-145 changes at early stages of the normal-adenoma-adenocarcinoma sequence. Thus, these microRNAs may play a role in the development of colon cancer." -tissue_expression_ns hsa-mir-19b-1 "Carcinoma, Colon" 26465597 "It is concluded that the expression of miR-17, miR-21, and miR-145 changes at early stages of the normal-adenoma-adenocarcinoma sequence. Thus, these microRNAs may play a role in the development of colon cancer." -tissue_expression_ns hsa-mir-20a "Carcinoma, Colon" 26465597 "It is concluded that the expression of miR-17, miR-21, and miR-145 changes at early stages of the normal-adenoma-adenocarcinoma sequence. Thus, these microRNAs may play a role in the development of colon cancer." -tissue_expression_ns hsa-mir-92-1 "Carcinoma, Colon" 26465597 "It is concluded that the expression of miR-17, miR-21, and miR-145 changes at early stages of the normal-adenoma-adenocarcinoma sequence. Thus, these microRNAs may play a role in the development of colon cancer." -tissue_expression_ns hsa-mir-99b Inflammatory Bowel Diseases 26466382 "These results suggest that the proposed miRNA signature is of relevance for the etiology of IBD. Its diagnostic value, however, should be further evaluated in large, independent, clinically well characterized cohorts." -tissue_expression_ns hsa-mir-182 Prostate Neoplasms 26484677 "Integrated Analysis Reveals together miR-182, miR-200c and miR-221 Can Help in the Diagnosis of Prostate Cancer." -tissue_expression_ns hsa-mir-200c Prostate Neoplasms 26484677 "Integrated Analysis Reveals together miR-182, miR-200c and miR-221 Can Help in the Diagnosis of Prostate Cancer." -tissue_expression_ns hsa-mir-221 Prostate Neoplasms 26484677 "Integrated Analysis Reveals together miR-182, miR-200c and miR-221 Can Help in the Diagnosis of Prostate Cancer." -tissue_expression_ns hsa-mir-100 Bladder Neoplasms 26489968 MiRNAs detected in urine and serum/plasma will demonstrate their potentiality to describe the variegated scenario of BC and to become relevant clinical markers. -tissue_expression_ns hsa-let-7g Alzheimer Disease 26497684 Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease. -tissue_expression_ns hsa-let-7g Parkinson Disease 26497684 Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease. -tissue_expression_ns hsa-mir-10a Alzheimer Disease 26497684 Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease. -tissue_expression_ns hsa-mir-10a Parkinson Disease 26497684 Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease. -tissue_expression_ns hsa-mir-153 Alzheimer Disease 26497684 Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease. -tissue_expression_ns hsa-mir-153 Parkinson Disease 26497684 Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease. -tissue_expression_ns hsa-mir-409 Alzheimer Disease 26497684 Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease. -tissue_expression_ns hsa-mir-409 Parkinson Disease 26497684 Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease. -tissue_expression_ns hsa-mir-510 "Carcinoma, Ovarian" 26497752 "Profile of differentially expressed miRNAs in high-grade serous carcinoma and clear cell ovarian carcinoma, and the expression of miR-510 in ovarian carcinoma." -tissue_expression_ns hsa-mir-30c "Carcinoma, Prostate" 26499781 The average relative expressions of hsa-miR-203 and hsa-miR-30c in tumor tissues were significantly different from those in adjacent normal tissues -tissue_expression_ns hsa-mir-155 Pancreatic Neoplasms 26499892 "We found miR-21, miR-155 or miR-217 expression values in tumors may differ up to several times" -tissue_expression_ns hsa-mir-196a Pancreatic Neoplasms 26499892 "Moreover, different internal controls can produce controversial results for miR-96, miR-148a or miR-196a quantification." -tissue_expression_ns hsa-mir-200b Hypertrophic Scar 26500110 Aberrant miR-21 and miR-200b expression and its pro-fibrotic potential in hypertrophic scars. -tissue_expression_ns hsa-mir-21 Hypertrophic Scar 26500110 Aberrant miR-21 and miR-200b expression and its pro-fibrotic potential in hypertrophic scars. -tissue_expression_ns hsa-mir-199a Diabetic Cardiomyopathies 26553540 A dysregulation of 316 out of 1008 total miRNAs was observed in the diabetic hearts when compared with controls. -tissue_expression_ns hsa-mir-203 Psoriasis 26559308 "Key roles of several unique miRNAs, such as miR-203 and miR-125b, in inflammatory responses and immune dysfunction, as well as hyperproliferative disorders of psoriatic lesions have been revealed." -tissue_expression_ns hsa-mir-192 Barrett Esophagus 26572780 "MicroRNAs miR-192, -194, -203, -205, and -215 are promising tissue biomarkers for diagnosing BE. Cross-sectional data suggest that microRNAs may have a limited role in separating BE from HGD/EAC epithelia but need further testing in longitudinal follow-up studies." -tissue_expression_ns hsa-mir-194 Barrett Esophagus 26572780 "MicroRNAs miR-192, -194, -203, -205, and -215 are promising tissue biomarkers for diagnosing BE. Cross-sectional data suggest that microRNAs may have a limited role in separating BE from HGD/EAC epithelia but need further testing in longitudinal follow-up studies." -tissue_expression_ns hsa-mir-203 Barrett Esophagus 26572780 "MicroRNAs miR-192, -194, -203, -205, and -215 are promising tissue biomarkers for diagnosing BE. Cross-sectional data suggest that microRNAs may have a limited role in separating BE from HGD/EAC epithelia but need further testing in longitudinal follow-up studies." -tissue_expression_ns hsa-mir-205 Barrett Esophagus 26572780 "MicroRNAs miR-192, -194, -203, -205, and -215 are promising tissue biomarkers for diagnosing BE. Cross-sectional data suggest that microRNAs may have a limited role in separating BE from HGD/EAC epithelia but need further testing in longitudinal follow-up studies." -tissue_expression_ns hsa-mir-215 Barrett Esophagus 26572780 "MicroRNAs miR-192, -194, -203, -205, and -215 are promising tissue biomarkers for diagnosing BE. Cross-sectional data suggest that microRNAs may have a limited role in separating BE from HGD/EAC epithelia but need further testing in longitudinal follow-up studies." -tissue_expression_ns hsa-mir-7 Schizophrenia 26572867 "Here we show post-transcriptional regulation of SHANK3 expression by three microRNAs (miRNAs), miR-7, miR-34a, and miR-504." -tissue_expression_ns hsa-mir-126 Bladder Neoplasms 26576778 "MicroRNA profiling from matched samples in patients shows a significant number of microRNAs up regulated in bladder tumors are identifiable in urine exosomes and WBCs of the same patient, but not in blood plasma. This study demonstrated varying relationships between miRNA detected in biological media from the same patient, and serves to inform the potential of urine-based microRNAs as biomarkers for bladder cancer and potentially other malignancies." -tissue_expression_ns hsa-mir-150 Bladder Neoplasms 26576778 "MicroRNA profiling from matched samples in patients shows a significant number of microRNAs up regulated in bladder tumors are identifiable in urine exosomes and WBCs of the same patient, but not in blood plasma. This study demonstrated varying relationships between miRNA detected in biological media from the same patient, and serves to inform the potential of urine-based microRNAs as biomarkers for bladder cancer and potentially other malignancies." -tissue_expression_ns hsa-mir-15b Bladder Neoplasms 26576778 "MicroRNA profiling from matched samples in patients shows a significant number of microRNAs up regulated in bladder tumors are identifiable in urine exosomes and WBCs of the same patient, but not in blood plasma. This study demonstrated varying relationships between miRNA detected in biological media from the same patient, and serves to inform the potential of urine-based microRNAs as biomarkers for bladder cancer and potentially other malignancies." -tissue_expression_ns hsa-mir-200c Bladder Neoplasms 26576778 "MicroRNA profiling from matched samples in patients shows a significant number of microRNAs up regulated in bladder tumors are identifiable in urine exosomes and WBCs of the same patient, but not in blood plasma. This study demonstrated varying relationships between miRNA detected in biological media from the same patient, and serves to inform the potential of urine-based microRNAs as biomarkers for bladder cancer and potentially other malignancies." -tissue_expression_ns hsa-mir-205 Bladder Neoplasms 26576778 "MicroRNA profiling from matched samples in patients shows a significant number of microRNAs up regulated in bladder tumors are identifiable in urine exosomes and WBCs of the same patient, but not in blood plasma. This study demonstrated varying relationships between miRNA detected in biological media from the same patient, and serves to inform the potential of urine-based microRNAs as biomarkers for bladder cancer and potentially other malignancies." -tissue_expression_ns hsa-mir-21 Bladder Neoplasms 26576778 "MicroRNA profiling from matched samples in patients shows a significant number of microRNAs up regulated in bladder tumors are identifiable in urine exosomes and WBCs of the same patient, but not in blood plasma. This study demonstrated varying relationships between miRNA detected in biological media from the same patient, and serves to inform the potential of urine-based microRNAs as biomarkers for bladder cancer and potentially other malignancies." -tissue_expression_ns hsa-mir-29b Bladder Neoplasms 26576778 "MicroRNA profiling from matched samples in patients shows a significant number of microRNAs up regulated in bladder tumors are identifiable in urine exosomes and WBCs of the same patient, but not in blood plasma. This study demonstrated varying relationships between miRNA detected in biological media from the same patient, and serves to inform the potential of urine-based microRNAs as biomarkers for bladder cancer and potentially other malignancies." -tissue_expression_ns hsa-mir-3007a Bladder Neoplasms 26576778 "MicroRNA profiling from matched samples in patients shows a significant number of microRNAs up regulated in bladder tumors are identifiable in urine exosomes and WBCs of the same patient, but not in blood plasma. This study demonstrated varying relationships between miRNA detected in biological media from the same patient, and serves to inform the potential of urine-based microRNAs as biomarkers for bladder cancer and potentially other malignancies." -tissue_expression_ns hsa-mir-4454 Bladder Neoplasms 26576778 "MicroRNA profiling from matched samples in patients shows a significant number of microRNAs up regulated in bladder tumors are identifiable in urine exosomes and WBCs of the same patient, but not in blood plasma. This study demonstrated varying relationships between miRNA detected in biological media from the same patient, and serves to inform the potential of urine-based microRNAs as biomarkers for bladder cancer and potentially other malignancies." -tissue_expression_ns hsa-mir-720 Bladder Neoplasms 26576778 "MicroRNA profiling from matched samples in patients shows a significant number of microRNAs up regulated in bladder tumors are identifiable in urine exosomes and WBCs of the same patient, but not in blood plasma. This study demonstrated varying relationships between miRNA detected in biological media from the same patient, and serves to inform the potential of urine-based microRNAs as biomarkers for bladder cancer and potentially other malignancies." -tissue_expression_ns hsa-mir-93 Bladder Neoplasms 26576778 "MicroRNA profiling from matched samples in patients shows a significant number of microRNAs up regulated in bladder tumors are identifiable in urine exosomes and WBCs of the same patient, but not in blood plasma. This study demonstrated varying relationships between miRNA detected in biological media from the same patient, and serves to inform the potential of urine-based microRNAs as biomarkers for bladder cancer and potentially other malignancies." -tissue_expression_ns hsa-mir-194 Choriocarcinoma 26578390 "we found hsa-miR-194 and hsa-miR-7 along with 7 transcription factors (TFs) such as SOX11, SMAD3 and SOX4 etc. could correctly differentiate SPN from PanNET" -tissue_expression_ns hsa-mir-204 Choriocarcinoma 26578390 "while hsa-miR-204 and 4 TFs such as SOX9, TCF7 and PPARD etc. were demonstrated as the potential markers for SPN versus PDAC." -tissue_expression_ns hsa-mir-7 Neoplasms [unspecific] 26578390 "we found hsa-miR-194 and hsa-miR-7 along with 7 transcription factors (TFs) such as SOX11, SMAD3 and SOX4 etc. could correctly differentiate SPN from PanNET" -tissue_expression_ns hsa-mir-106b Hepatoblastoma 26613016 These datasets provide a global landscape of miRNA expression for a rare childhood cancer that has not previously been well characterised. These data could serve as a resource for future studies aiming to make comparisons of HB miRNA profiles and to document aberrant miRNA expression in this type of cancer. -tissue_expression_ns hsa-mir-17 Hepatoblastoma 26613016 These datasets provide a global landscape of miRNA expression for a rare childhood cancer that has not previously been well characterised. These data could serve as a resource for future studies aiming to make comparisons of HB miRNA profiles and to document aberrant miRNA expression in this type of cancer. -tissue_expression_ns hsa-mir-191 Hepatoblastoma 26613016 These datasets provide a global landscape of miRNA expression for a rare childhood cancer that has not previously been well characterised. These data could serve as a resource for future studies aiming to make comparisons of HB miRNA profiles and to document aberrant miRNA expression in this type of cancer. -tissue_expression_ns hsa-mir-95 Hepatoblastoma 26613016 These datasets provide a global landscape of miRNA expression for a rare childhood cancer that has not previously been well characterised. These data could serve as a resource for future studies aiming to make comparisons of HB miRNA profiles and to document aberrant miRNA expression in this type of cancer. -tissue_expression_ns hsa-mir-149 Glioma 26617839 "Our study thus demonstrates that miR-149 expression in glioma tissues is critically associated with the prognosis of patients,suggesting its potential clinical significance." -tissue_expression_ns hsa-mir-155 Stroke 26663183 "we will provide insight into recent knowledge from animal and human studies concerning miRNA profiling in acute stroke and their expression dynamics in brain tissue and extracellular fluids (roles of, e.g. let-7 family, miR-21, miR-29 family, miR-124, miR-145, miR-181 family, miR-210 and miR-223)" -tissue_expression_ns hsa-mir-126 Ischemia 26672806 ghrelin treatment activated proangiogenic (miR-126 and miR-132) and antifibrotic (miR-30a) microRNAs (miRs) -tissue_expression_ns hsa-mir-206 Ischemia 26672806 ghrelin treatment activated proangiogenic (miR-126 and miR-132) and antifibrotic (miR-30a) microRNAs (miRs) -tissue_expression_ns hsa-mir-92a Ischemia 26672806 "Further, ghrelin treatment activated proangiogenic (miR-126 and miR-132) and antifibrotic (miR-30a) microRNAs (miRs) while inhibiting antiangiogenic (miR-92a and miR-206) miRs." -tissue_expression_ns hsa-mir-375 Colorectal Carcinoma 26681654 "While the intra-tumor variance of miR-92a, miR-375 and miR-424 is substantial, it only constitutes approximately 30% of the total variation. Functional deregulation between tumor zones might contribute to variations in measured expression levels, and thus knowledge of specific intra-tumor expression patterns is crucial in tissue sampling for research as well as in future diagnostics." -tissue_expression_ns hsa-mir-424 Colorectal Carcinoma 26681654 "While the intra-tumor variance of miR-92a, miR-375 and miR-424 is substantial, it only constitutes approximately 30% of the total variation. Functional deregulation between tumor zones might contribute to variations in measured expression levels, and thus knowledge of specific intra-tumor expression patterns is crucial in tissue sampling for research as well as in future diagnostics." -tissue_expression_ns hsa-mir-92a Colorectal Carcinoma 26681654 "While the intra-tumor variance of miR-92a, miR-375 and miR-424 is substantial, it only constitutes approximately 30% of the total variation. Functional deregulation between tumor zones might contribute to variations in measured expression levels, and thus knowledge of specific intra-tumor expression patterns is crucial in tissue sampling for research as well as in future diagnostics." -tissue_expression_ns hsa-mir-106b Breast Neoplasms 26684238 "Taken together, we have for the first time characterized the BMP4-induced miRNA expression profiles in breast cancer cell lines, showing that induced miRNAs contribute to the fine-tuning of proliferation and migration phenotypes." -tissue_expression_ns hsa-mir-16 Breast Neoplasms 26684238 "Taken together, we have for the first time characterized the BMP4-induced miRNA expression profiles in breast cancer cell lines, showing that induced miRNAs contribute to the fine-tuning of proliferation and migration phenotypes." -tissue_expression_ns hsa-mir-23a Breast Neoplasms 26684238 "Taken together, we have for the first time characterized the BMP4-induced miRNA expression profiles in breast cancer cell lines, showing that induced miRNAs contribute to the fine-tuning of proliferation and migration phenotypes." -tissue_expression_ns hsa-mir-23b Breast Neoplasms 26684238 "Taken together, we have for the first time characterized the BMP4-induced miRNA expression profiles in breast cancer cell lines, showing that induced miRNAs contribute to the fine-tuning of proliferation and migration phenotypes." -tissue_expression_ns hsa-mir-222 Pulmonary Sarcoidosis 26696750 "miRNAs in sarcoid BAL cells detected deregulation of miR-146a, miR-150, miR-202, miR-204, and miR-222 expression comparing to controls" -tissue_expression_ns hsa-mir-1909 Neuroepithelial Tumors 26698155 "Our findings indicated that miR-3138 might act as a tumor suppressor gene when down-regulated and miR-1909* as a putative oncogenic molecule when up-regulated in pediatric DNETs compared to the control cohort. Subsequently, both miRNA signatures might serve as putative diagnostic biomarkers for pediatric DNETs." -tissue_expression_ns hsa-mir-3138 Neuroepithelial Tumors 26698155 "Our findings indicated that miR-3138 might act as a tumor suppressor gene when down-regulated and miR-1909* as a putative oncogenic molecule when up-regulated in pediatric DNETs compared to the control cohort. Subsequently, both miRNA signatures might serve as putative diagnostic biomarkers for pediatric DNETs." -tissue_expression_ns hsa-mir-100 Colorectal Carcinoma 26714601 "The expression of miR-100 is correlated with lymph node metastasis, TNM stage and differentiation grade, and may be a potential biomarker indicating the development of CRC." -tissue_expression_ns hsa-mir-145 Lupus Nephritis 26722454 Association of miRNA-145 expression in vascular smooth muscle cells with vascular damages in patients with lupus nephritis. -tissue_expression_ns hsa-mir-203 Diabetic Foot 26722550 "Our results demonstrated that expression profile of miR-203 in diabetic foot had a positive correlation with the severity of diabetic foot ulcers, which indicated that miR-203 can be served as a new, accurate and validated bio-marker for evaluating the severity of diabetic foot ulcers in clinic. The significant finding of the study: Quantification of miR-203 in different degrees of diabetic foot. This study adds a new bio-marker for evaluation and management of diabetic foot." -tissue_expression_ns hsa-mir-182 "Carcinoma, Hepatocellular" 26728044 "In this study, fifteen microRNAs which were modulated in hepatic tissues and in tumors during the transition NAFLD-NASH-HCC are reported. Besides some already described, new and early dysregulated miRNAs were identified.Functional analyses are needed to validate the results here obtained, and to better define the role of these molecules in the progression of the hepatic disease." -tissue_expression_ns hsa-mir-340 "Carcinoma, Hepatocellular" 26728044 "In this study, fifteen microRNAs which were modulated in hepatic tissues and in tumors during the transition NAFLD-NASH-HCC are reported. Besides some already described, new and early dysregulated miRNAs were identified.Functional analyses are needed to validate the results here obtained, and to better define the role of these molecules in the progression of the hepatic disease." -tissue_expression_ns hsa-mir-484 "Carcinoma, Hepatocellular" 26728044 "In this study, fifteen microRNAs which were modulated in hepatic tissues and in tumors during the transition NAFLD-NASH-HCC are reported. Besides some already described, new and early dysregulated miRNAs were identified.Functional analyses are needed to validate the results here obtained, and to better define the role of these molecules in the progression of the hepatic disease." -tissue_expression_ns hsa-mir-574 "Carcinoma, Hepatocellular" 26728044 "In this study, fifteen microRNAs which were modulated in hepatic tissues and in tumors during the transition NAFLD-NASH-HCC are reported. Besides some already described, new and early dysregulated miRNAs were identified.Functional analyses are needed to validate the results here obtained, and to better define the role of these molecules in the progression of the hepatic disease." -tissue_expression_ns hsa-mir-720 "Carcinoma, Hepatocellular" 26728044 "In this study, fifteen microRNAs which were modulated in hepatic tissues and in tumors during the transition NAFLD-NASH-HCC are reported. Besides some already described, new and early dysregulated miRNAs were identified.Functional analyses are needed to validate the results here obtained, and to better define the role of these molecules in the progression of the hepatic disease." -tissue_expression_ns hsa-mir-21 "Carcinoma, Renal Cell" 26729387 Diagnostic and prognostic accuracy of miR-21 in renal cell carcinoma: a systematic review protocol. -tissue_expression_ns hsa-mir-1 Myocardial Ischemic-Reperfusion Injury 26738985 "Of the 17 miRs, 9 miRs, including miR-1, miR-21, miR-24, and miR-195, which are related to apoptosis, exhibited different expression patterns in the RIPerc group compared with the control." -tissue_expression_ns hsa-mir-195 Myocardial Ischemic-Reperfusion Injury 26738985 "Of the 17 miRs, 9 miRs, including miR-1, miR-21, miR-24, and miR-195, which are related to apoptosis, exhibited different expression patterns in the RIPerc group compared with the control." -tissue_expression_ns hsa-mir-200b Melanoma 26743475 "miR-10b and miR-200b showed independent prognostic value (P=0.002 and 0.047, respectively) in multivariable analysis alongside known clinico-pathological prognostic features" -tissue_expression_ns hsa-mir-141 Prostate Neoplasms 26751899 miRNAs as novel biomarkers in the management of prostate cancer. -tissue_expression_ns hsa-mir-21 Prostate Neoplasms 26751899 miRNAs as novel biomarkers in the management of prostate cancer. -tissue_expression_ns hsa-mir-375 Prostate Neoplasms 26751899 miRNAs as novel biomarkers in the management of prostate cancer. -tissue_expression_ns hsa-mir-146a Autism Spectrum Disorder 26753090 "We identified a signature of four miRNAs (miR-146a, miR-221, miR-654-5p, and miR-656) commonly deregulated in ASD." -tissue_expression_ns hsa-mir-221 Autism Spectrum Disorder 26753090 "We identified a signature of four miRNAs (miR-146a, miR-221, miR-654-5p, and miR-656) commonly deregulated in ASD." -tissue_expression_ns hsa-mir-125a Lupus Nephritis 26762103 "Levels of cell-free miR-125a, miR-150, and miR-155 in the urine supernatant are associated with the expression of LN-Panel biomarkers and some LN measures. These miRNA's may complement, but are unlikely superior to the LN-Panel for estimating concurrent LN activity." -tissue_expression_ns hsa-mir-127 Lupus Nephritis 26762103 "Levels of cell-free miR-125a, miR-150, and miR-155 in the urine supernatant are associated with the expression of LN-Panel biomarkers and some LN measures. These miRNA's may complement, but are unlikely superior to the LN-Panel for estimating concurrent LN activity." -tissue_expression_ns hsa-mir-146a Lupus Nephritis 26762103 "Levels of cell-free miR-125a, miR-150, and miR-155 in the urine supernatant are associated with the expression of LN-Panel biomarkers and some LN measures. These miRNA's may complement, but are unlikely superior to the LN-Panel for estimating concurrent LN activity." -tissue_expression_ns hsa-mir-150 Lupus Nephritis 26762103 "Levels of cell-free miR-125a, miR-150, and miR-155 in the urine supernatant are associated with the expression of LN-Panel biomarkers and some LN measures. These miRNA's may complement, but are unlikely superior to the LN-Panel for estimating concurrent LN activity." -tissue_expression_ns hsa-mir-155 Lupus Nephritis 26762103 "Levels of cell-free miR-125a, miR-150, and miR-155 in the urine supernatant are associated with the expression of LN-Panel biomarkers and some LN measures. These miRNA's may complement, but are unlikely superior to the LN-Panel for estimating concurrent LN activity." -tissue_expression_ns hsa-mir-126 Mesothelioma 26765063 "Subject to validation of the current results in further larger studies, miR-21 and miR-126 profiling could be an effective and reliable tool for the diagnosis of MM in pleural effusions complementary to cytology evaluation." -tissue_expression_ns hsa-mir-21 Mesothelioma 26765063 "Subject to validation of the current results in further larger studies, miR-21 and miR-126 profiling could be an effective and reliable tool for the diagnosis of MM in pleural effusions complementary to cytology evaluation." -tissue_expression_ns hsa-let-7f Pulmonary Sarcoidosis 26768132 "The obtained results suggest that the studied miRNAs play a role in the pathogenesis of sarcoidosis, and that some of them might have negative prognostic value." -tissue_expression_ns hsa-mir-128a Pulmonary Sarcoidosis 26768132 "The obtained results suggest that the studied miRNAs play a role in the pathogenesis of sarcoidosis, and that some of them might have negative prognostic value." -tissue_expression_ns hsa-mir-130a Pulmonary Sarcoidosis 26768132 "The obtained results suggest that the studied miRNAs play a role in the pathogenesis of sarcoidosis, and that some of them might have negative prognostic value." -tissue_expression_ns hsa-mir-15b Pulmonary Sarcoidosis 26768132 "The obtained results suggest that the studied miRNAs play a role in the pathogenesis of sarcoidosis, and that some of them might have negative prognostic value." -tissue_expression_ns hsa-mir-16 Pulmonary Sarcoidosis 26768132 "The obtained results suggest that the studied miRNAs play a role in the pathogenesis of sarcoidosis, and that some of them might have negative prognostic value." -tissue_expression_ns hsa-mir-192 Pulmonary Sarcoidosis 26768132 "The obtained results suggest that the studied miRNAs play a role in the pathogenesis of sarcoidosis, and that some of them might have negative prognostic value." -tissue_expression_ns hsa-mir-20a Pulmonary Sarcoidosis 26768132 "The obtained results suggest that the studied miRNAs play a role in the pathogenesis of sarcoidosis, and that some of them might have negative prognostic value." -tissue_expression_ns hsa-mir-221 Pulmonary Sarcoidosis 26768132 "The obtained results suggest that the studied miRNAs play a role in the pathogenesis of sarcoidosis, and that some of them might have negative prognostic value." -tissue_expression_ns hsa-mir-222 Pulmonary Sarcoidosis 26768132 "The obtained results suggest that the studied miRNAs play a role in the pathogenesis of sarcoidosis, and that some of them might have negative prognostic value." -tissue_expression_ns hsa-mir-1244 Gastric Cardia Adenocarcinoma 26781873 "Four miRNAs (miR-1244, miR-135b-5p, miR-3196, and miR-628-3p) were found to be associated with GCA differentiation." -tissue_expression_ns hsa-mir-135b Gastric Cardia Adenocarcinoma 26781873 "Four miRNAs (miR-1244, miR-135b-5p, miR-3196, and miR-628-3p) were found to be associated with GCA differentiation." -tissue_expression_ns hsa-mir-196a Gastric Cardia Adenocarcinoma 26781873 "miR-196a-5p, was found to be associated with age of GCA onset." -tissue_expression_ns hsa-mir-3196 Gastric Cardia Adenocarcinoma 26781873 "Four miRNAs (miR-1244, miR-135b-5p, miR-3196, and miR-628-3p) were found to be associated with GCA differentiation." -tissue_expression_ns hsa-mir-628 Gastric Cardia Adenocarcinoma 26781873 "Four miRNAs (miR-1244, miR-135b-5p, miR-3196, and miR-628-3p) were found to be associated with GCA differentiation." -tissue_expression_ns hsa-mir-494 Pancreatic Neoplasms 26782462 Correlation of miR-494 expression with tumor progression and patient survival in pancreatic cancer. -tissue_expression_ns hsa-mir-21 Glioma 26799295 "4 hypoxia-mediated microRNAs (miRNA)-miR-210, miR-21, miR-10b, and miR-196b-are upregulated in glioma" -tissue_expression_ns hsa-mir-199a Melanoma 26812476 "Five miRNAs (miR-214, miR146b, miR-143, miR-199a and miR-134) were found to be differentially expressed in M3/ D3 UM tumors." -tissue_expression_ns hsa-mir-146a Vogt-Koyanagi-Harada Disease 26818976 "CNVs of miR-146a, miR-23a and miR-301a confer susceptibility to VKH syndrome, but not to BD." -tissue_expression_ns hsa-mir-1 Endometriosis 26819681 "The expression of miR-1, miR-133a, and miR-451 were reduced significantly (p<0.0001) in the OC patients compared to its associated endometriosis." -tissue_expression_ns hsa-mir-141 Neoplasms [unspecific] 26828359 microRNA (miR)-141 is aberrantly expressed in many human malignant tumors -tissue_expression_ns hsa-mir-223 Autoimmune Diseases [unspecific] 26879236 using co-expression analysis of miRNA expression levels we showed that multiple miRNA contribute to multiple pathways that might be involved in pathogenesis of autoimmune skin blistering disease. -tissue_expression_ns hsa-mir-181c "Squamous Cell Carcinoma, Esophageal" 26888510 "There are significant correlation between miR-181c-3p/miR-5692b expression, clinicopathologic parameters and prognosis. They represent potential prognostic biomarkers in esophageal squamous cell carcinoma." -tissue_expression_ns hsa-mir-5692b "Squamous Cell Carcinoma, Esophageal" 26888510 "There are significant correlation between miR-181c-3p/miR-5692b expression, clinicopathologic parameters and prognosis. They represent potential prognostic biomarkers in esophageal squamous cell carcinoma." -tissue_expression_ns hsa-mir-21 Breast Neoplasms 26891730 Analysis has shown that changes in miR-21 levels might be important for the later and/or late phases of breast cancerogenesis rather than for the initial early phases. -tissue_expression_ns hsa-mir-124a Breast Neoplasms 26897751 MiR-124a and miR-30d were correlated with insulin resistance and development of BC with T2DM. -tissue_expression_ns hsa-mir-124a "Diabetes Mellitus, Type 2" 26897751 MiR-124a and miR-30d were correlated with insulin resistance and development of BC with T2DM. -tissue_expression_ns hsa-mir-30d Breast Neoplasms 26897751 MiR-124a and miR-30d were correlated with insulin resistance and development of BC with T2DM. -tissue_expression_ns hsa-mir-30d "Diabetes Mellitus, Type 2" 26897751 MiR-124a and miR-30d were correlated with insulin resistance and development of BC with T2DM. -tissue_expression_ns hsa-mir-181c Silicosis 26903263 The differential expression of two selected miRNAs hsa-miR-181c-5p and hsa-miR-29a-3p were confirmed by RT-qPCR. -tissue_expression_ns hsa-mir-29a Silicosis 26903263 The differential expression of two selected miRNAs hsa-miR-181c-5p and hsa-miR-29a-3p were confirmed by RT-qPCR. -tissue_expression_ns hsa-mir-27a Colorectal Carcinoma 26913599 Low miR-27a-expressing cells displayed more ecto-calreticulin on the cell surface and increased ATP and HMGB1 secretion than high miR-27a-expressing ones in time-course experiments upon drug exposure. -tissue_expression_ns hsa-mir-130b "Carcinoma, Hepatocellular" 26927562 The expression and clinopathological significance of miR-130b in human hepatocellular carcinoma -tissue_expression_ns hsa-let-7g Rectal Neoplasms 26937645 "We recommend the mean expression of miR-27a, miR-193a-5p and let-7g as normalisation factor, when performing miRNA expression analyses by RT-qPCR on rectal cancer tissue." -tissue_expression_ns hsa-mir-193a Rectal Neoplasms 26937645 "We recommend the mean expression of miR-27a, miR-193a-5p and let-7g as normalisation factor, when performing miRNA expression analyses by RT-qPCR on rectal cancer tissue." -tissue_expression_ns hsa-mir-27a Rectal Neoplasms 26937645 "We recommend the mean expression of miR-27a, miR-193a-5p and let-7g as normalisation factor, when performing miRNA expression analyses by RT-qPCR on rectal cancer tissue." -tissue_expression_ns hsa-mir-645 Rectal Neoplasms 26937645 "We recommend the mean expression of miR-27a, miR-193a-5p and let-7g as normalisation factor, when performing miRNA expression analyses by RT-qPCR on rectal cancer tissue." -tissue_expression_ns hsa-let-7c Breast Neoplasms 26982264 "we identified seven miRNAs (miR-9-5p, miR-9-3p, let-7c, miR-127-3p, miR-99a-5p, miR-129-5p, and miR-146a-5p) that were deregulated as a consequence of claudin 1 overexpression in the MDA-MB231 human breast cancer (HBC) cell line." -tissue_expression_ns hsa-mir-127 Breast Neoplasms 26982264 "we identified seven miRNAs (miR-9-5p, miR-9-3p, let-7c, miR-127-3p, miR-99a-5p, miR-129-5p, and miR-146a-5p) that were deregulated as a consequence of claudin 1 overexpression in the MDA-MB231 human breast cancer (HBC) cell line." -tissue_expression_ns hsa-mir-129 Breast Neoplasms 26982264 "we identified seven miRNAs (miR-9-5p, miR-9-3p, let-7c, miR-127-3p, miR-99a-5p, miR-129-5p, and miR-146a-5p) that were deregulated as a consequence of claudin 1 overexpression in the MDA-MB231 human breast cancer (HBC) cell line." -tissue_expression_ns hsa-mir-146a Breast Neoplasms 26982264 "we identified seven miRNAs (miR-9-5p, miR-9-3p, let-7c, miR-127-3p, miR-99a-5p, miR-129-5p, and miR-146a-5p) that were deregulated as a consequence of claudin 1 overexpression in the MDA-MB231 human breast cancer (HBC) cell line." -tissue_expression_ns hsa-mir-9 Breast Neoplasms 26982264 "we identified seven miRNAs (miR-9-5p, miR-9-3p, let-7c, miR-127-3p, miR-99a-5p, miR-129-5p, and miR-146a-5p) that were deregulated as a consequence of claudin 1 overexpression in the MDA-MB231 human breast cancer (HBC) cell line." -tissue_expression_ns hsa-mir-99a Breast Neoplasms 26982264 "we identified seven miRNAs (miR-9-5p, miR-9-3p, let-7c, miR-127-3p, miR-99a-5p, miR-129-5p, and miR-146a-5p) that were deregulated as a consequence of claudin 1 overexpression in the MDA-MB231 human breast cancer (HBC) cell line." -tissue_expression_ns hsa-mir-199a "Carcinoma, Hepatocellular" 26998997 miTALOS v2: Analyzing Tissue Specific microRNA Function. -tissue_expression_ns hsa-mir-199b "Carcinoma, Hepatocellular" 26998997 miTALOS v3: Analyzing Tissue Specific microRNA Function. -tissue_expression_ns hsa-mir-200 "Carcinoma, Hepatocellular" 26998997 miTALOS v4: Analyzing Tissue Specific microRNA Function. -tissue_expression_ns hsa-mir-571 "Carcinoma, Hepatocellular" 26998997 miTALOS v5: Analyzing Tissue Specific microRNA Function. -tissue_expression_ns hsa-mir-223 Multiple Myeloma 27023728 miR-223 expression in MM-BMMSCs was reduced by the presence of MM cells -tissue_expression_ns hsa-mir-126 Traumatic Brain Injury 27027233 Our results indicated that altered expression of miR-126-3p and miR-3610 may play an important role in the development of TBI-induced hypopituitarism. -tissue_expression_ns hsa-mir-3610 Traumatic Brain Injury 27027233 Our results indicated that altered expression of miR-126-3p and miR-3610 may play an important role in the development of TBI-induced hypopituitarism. -tissue_expression_ns hsa-mir-130a Cardiotoxicity 27033315 "We report on several microRNAs, including miR-34a, miR-34b, miR-187, miR-199a, miR-199b, miR-146a, miR-15b, miR-130a, miR-214, and miR-424, that are differentially expressed upon, and after, treatment with doxorubicin." -tissue_expression_ns hsa-mir-146a Cardiotoxicity 27033315 "We report on several microRNAs, including miR-34a, miR-34b, miR-187, miR-199a, miR-199b, miR-146a, miR-15b, miR-130a, miR-214, and miR-424, that are differentially expressed upon, and after, treatment with doxorubicin." -tissue_expression_ns hsa-mir-15b Cardiotoxicity 27033315 "We report on several microRNAs, including miR-34a, miR-34b, miR-187, miR-199a, miR-199b, miR-146a, miR-15b, miR-130a, miR-214, and miR-424, that are differentially expressed upon, and after, treatment with doxorubicin." -tissue_expression_ns hsa-mir-187 Cardiotoxicity 27033315 "We report on several microRNAs, including miR-34a, miR-34b, miR-187, miR-199a, miR-199b, miR-146a, miR-15b, miR-130a, miR-214, and miR-424, that are differentially expressed upon, and after, treatment with doxorubicin." -tissue_expression_ns hsa-mir-199a Cardiotoxicity 27033315 "We report on several microRNAs, including miR-34a, miR-34b, miR-187, miR-199a, miR-199b, miR-146a, miR-15b, miR-130a, miR-214, and miR-424, that are differentially expressed upon, and after, treatment with doxorubicin." -tissue_expression_ns hsa-mir-199b Cardiotoxicity 27033315 "We report on several microRNAs, including miR-34a, miR-34b, miR-187, miR-199a, miR-199b, miR-146a, miR-15b, miR-130a, miR-214, and miR-424, that are differentially expressed upon, and after, treatment with doxorubicin." -tissue_expression_ns hsa-mir-214 Cardiotoxicity 27033315 "We report on several microRNAs, including miR-34a, miR-34b, miR-187, miR-199a, miR-199b, miR-146a, miR-15b, miR-130a, miR-214, and miR-424, that are differentially expressed upon, and after, treatment with doxorubicin." -tissue_expression_ns hsa-mir-34a Cardiotoxicity 27033315 "We report on several microRNAs, including miR-34a, miR-34b, miR-187, miR-199a, miR-199b, miR-146a, miR-15b, miR-130a, miR-214, and miR-424, that are differentially expressed upon, and after, treatment with doxorubicin." -tissue_expression_ns hsa-mir-34b Cardiotoxicity 27033315 "We report on several microRNAs, including miR-34a, miR-34b, miR-187, miR-199a, miR-199b, miR-146a, miR-15b, miR-130a, miR-214, and miR-424, that are differentially expressed upon, and after, treatment with doxorubicin." -tissue_expression_ns hsa-mir-424 Cardiotoxicity 27033315 "We report on several microRNAs, including miR-34a, miR-34b, miR-187, miR-199a, miR-199b, miR-146a, miR-15b, miR-130a, miR-214, and miR-424, that are differentially expressed upon, and after, treatment with doxorubicin." -tissue_expression_ns hsa-mir-148a Osteosarcoma 27041566 we show that miR-148a-3p and miR-155-5p are species-conserved deregulated miRNA in OS -tissue_expression_ns hsa-mir-155 Osteosarcoma 27041566 we show that miR-148a-3p and miR-155-5p are species-conserved deregulated miRNA in OS -tissue_expression_ns hsa-let-7f Obesity 27049726 "Our study shows that the first evidence of hsa-let-7 family, hsa-miR-15a-5p, hsa-miR-27a-3p, hsa-miR-106b-5p, hsa-miR-148a-3p and hsa-miR-26b-5p got a great weight in adipogenesis" -tissue_expression_ns hsa-mir-1275 "Squamous Cell Carcinoma, Oral" 27056547 "the expression of miR-1275 was variable in tumours, with high levels associated to regional lymph node invasion;" -tissue_expression_ns hsa-mir-29a "Carcinoma, Ovarian, Serous" 27063471 "miR-29a and its target DNMT3A are novel candidate biomarkers of longer and shorter survival, respectively, in metastatic high-grade serous carcinoma." -tissue_expression_ns hsa-mir-21 "Adenocarcinoma, Lung" 27081085 "We identified a regulatory network including miR-15b and miR-155, and transcription factors with prognostic value in lung cancer." -tissue_expression_ns hsa-mir-139 Breast Neoplasms 27082076 miRNAs included in the invasive signatures include downregulation of miR-139-5p in aggressive subtypes and upregulation of miR-29c-5p expression in the luminal subtypes. -tissue_expression_ns hsa-mir-29c Breast Neoplasms 27082076 include downregulation of miR-139-5p in aggressive subtypes and upregulation of miR-29c-5p expression in the luminal subtypes. -tissue_expression_ns hsa-mir-21 "Adenocarcinoma, Pancreatic Ductal" 27086919 We provide further evidence for using miRNAs as diagnostic biomarkers for pancreatic malignancy. -tissue_expression_ns hsa-mir-196 Tuberculosis 27102525 9 miRNAs were differentially expressed after MAP infection. -tissue_expression_ns hsa-mir-24 Cardiovascular Diseases [unspecific] 27108908 "The dysregulation of miR-24 is associated with dysfunction or even damage of VECs, and contributes to the development of cardiovascular disease." -tissue_expression_ns hsa-mir-21 "Carcinoma, Breast, Triple Negative" 27113307 The function of MiR-21 expression differences and pathogenesis on familial and triple negative breast Cancer serum. -tissue_expression_ns hsa-mir-223 Inflammation 27129807 "miR-223 that has been reported to be abnormally expressed in several diseases like diabetes-type2, sepsis, rheumatoid arthritis, viral infections likes' human immunodeficiency virus-1 (HIV-1) and inflammatory disorders." -tissue_expression_ns hsa-mir-223 Sepsis 27129807 "miR-223 that has been reported to be abnormally expressed in several diseases like diabetes-type2, sepsis, rheumatoid arthritis, viral infections likes' human immunodeficiency virus-1 (HIV-1) and inflammatory disorders." -tissue_expression_ns hsa-mir-200 Colorectal Carcinoma 27157610 "The miR-200 family presented as the most powerful determinant of CMS4-specific gene expression, tuning the majority of genes differentially expressed in the poor prognosis subtype," -tissue_expression_ns hsa-mir-125b Oral Neoplasms 27208839 "Differential expression of miR-21, miR-100, miR-125b and miR-375 was validated in oral cytology training sample set." -tissue_expression_ns hsa-mir-150 Bronchopulmonary Dysplasia 27216745 expression of miR-150 was altered in experimental BPD -tissue_expression_ns hsa-mir-127 Balkan Nephropathy 27218105 " Only three microRNAs (hsa-miR-127-3p, hsa-miR-154-5p, and hsa-miR-30a-5p) were downregulated among BEN-UTUC, and one microRNA (hsa-miR-663b) was downregulated among non-BEN-UTUC samples" -tissue_expression_ns hsa-mir-154 Balkan Nephropathy 27218105 " Only three microRNAs (hsa-miR-127-3p, hsa-miR-154-5p, and hsa-miR-30a-5p) were downregulated among BEN-UTUC, and one microRNA (hsa-miR-663b) was downregulated among non-BEN-UTUC samples" -tissue_expression_ns hsa-mir-30a Balkan Nephropathy 27218105 " Only three microRNAs (hsa-miR-127-3p, hsa-miR-154-5p, and hsa-miR-30a-5p) were downregulated among BEN-UTUC, and one microRNA (hsa-miR-663b) was downregulated among non-BEN-UTUC samples" -tissue_expression_ns hsa-mir-663b Balkan Nephropathy 27218105 " Only three microRNAs (hsa-miR-127-3p, hsa-miR-154-5p, and hsa-miR-30a-5p) were downregulated among BEN-UTUC, and one microRNA (hsa-miR-663b) was downregulated among non-BEN-UTUC samples" -tissue_expression_ns hsa-mir-765 Soft Tissue Sarcoma 27223121 miR-765 could possibly be a diagnostic tool for ES because of its 97% specificity and 80% sensitivity. -tissue_expression_ns hsa-mir-630 Rectum Adenocarcinoma 27225591 The miR-630 appeared only with the NR patients and was anti-correlated with a single transcript: RAB5B. -tissue_expression_ns hsa-mir-138 Down Syndrome 27266699 The function of hsa-miR-138-5p and its target EZH2 was involved in hippocampus in DS patients. -tissue_expression_ns hsa-mir-138 Chondrosarcoma 27267924 "increased expression of two microRNAs, miRs-181a and -138, in low-grade chondrosarcomas compared with enchondromas" -tissue_expression_ns hsa-mir-126 "Adenocarcinoma, Lung" 27277197 "Low levels of miR-126-3p and miR-451a were associated with poor pathological stage, large tumor diameter and lymph node metastasis" -tissue_expression_ns hsa-mir-451a "Adenocarcinoma, Lung" 27277197 "Low levels of miR-126-3p and miR-451a were associated with poor pathological stage, large tumor diameter and lymph node metastasis" -tissue_expression_ns hsa-mir-155 Laryngeal Neoplasms 27292022 "miR-21, miR-155, miR-192, and miR-375 Deregulations Related to NF-kappaB Activation in Gastroduodenal Fluid-Induced Early Preneoplastic Lesions of Laryngeal Mucosa In Vivo." -tissue_expression_ns hsa-mir-192 Laryngeal Neoplasms 27292022 "miR-21, miR-155, miR-192, and miR-375 Deregulations Related to NF-kappaB Activation in Gastroduodenal Fluid-Induced Early Preneoplastic Lesions of Laryngeal Mucosa In Vivo." -tissue_expression_ns hsa-mir-21 Laryngeal Neoplasms 27292022 "miR-21, miR-155, miR-192, and miR-375 Deregulations Related to NF-kappaB Activation in Gastroduodenal Fluid-Induced Early Preneoplastic Lesions of Laryngeal Mucosa In Vivo." -tissue_expression_ns hsa-mir-375 Laryngeal Neoplasms 27292022 "miR-21, miR-155, miR-192, and miR-375 Deregulations Related to NF-kappaB Activation in Gastroduodenal Fluid-Induced Early Preneoplastic Lesions of Laryngeal Mucosa In Vivo." -tissue_expression_ns hsa-mir-26a Multiple Sclerosis 27310932 down-regulation of miR-155 and miR-26a was seen in MS patients during and after natalizumab therapy. -tissue_expression_ns hsa-mir-146a Melanoma 27311960 "miR-146a controls melanoma progression in a dual way, promoting growth and inhibiting dissemination" -tissue_expression_ns hsa-mir-130a "Carcinoma, Nasopharyngeal" 27350400 "hsa-miR-205, hsa-miR-18b, hsa-miR-632, hsa-miR-130a, and hsa-miR-34b may be related to the development of nasopharyngeal carcinoma" -tissue_expression_ns hsa-mir-18b "Carcinoma, Nasopharyngeal" 27350400 "hsa-miR-205, hsa-miR-18b, hsa-miR-632, hsa-miR-130a, and hsa-miR-34b may be related to the development of nasopharyngeal carcinoma" -tissue_expression_ns hsa-mir-205 "Carcinoma, Nasopharyngeal" 27350400 "hsa-miR-205, hsa-miR-18b, hsa-miR-632, hsa-miR-130a, and hsa-miR-34b may be related to the development of nasopharyngeal carcinoma" -tissue_expression_ns hsa-mir-34b "Carcinoma, Nasopharyngeal" 27350400 "hsa-miR-205, hsa-miR-18b, hsa-miR-632, hsa-miR-130a, and hsa-miR-34b may be related to the development of nasopharyngeal carcinoma" -tissue_expression_ns hsa-mir-632 "Carcinoma, Nasopharyngeal" 27350400 "hsa-miR-205, hsa-miR-18b, hsa-miR-632, hsa-miR-130a, and hsa-miR-34b may be related to the development of nasopharyngeal carcinoma" -tissue_expression_ns hsa-mir-141 Bladder Neoplasms 27357429 two types of cancer showed opposite expression patterns for miR-200 family miRNAs -tissue_expression_ns hsa-mir-141 "Carcinoma, Renal Cell" 27357429 two types of cancer showed opposite expression patterns for miR-200 family miRNAs -tissue_expression_ns hsa-mir-200 Bladder Neoplasms 27357429 two types of cancer showed opposite expression patterns for miR-200 family miRNAs -tissue_expression_ns hsa-mir-200 "Carcinoma, Renal Cell" 27357429 two types of cancer showed opposite expression patterns for miR-200 family miRNAs -tissue_expression_ns hsa-mir-200a Bladder Neoplasms 27357429 two types of cancer showed opposite expression patterns for miR-200 family miRNAs -tissue_expression_ns hsa-mir-200a "Carcinoma, Renal Cell" 27357429 two types of cancer showed opposite expression patterns for miR-200 family miRNAs -tissue_expression_ns hsa-mir-200b Bladder Neoplasms 27357429 two types of cancer showed opposite expression patterns for miR-200 family miRNAs -tissue_expression_ns hsa-mir-200b "Carcinoma, Renal Cell" 27357429 two types of cancer showed opposite expression patterns for miR-200 family miRNAs -tissue_expression_ns hsa-mir-200c Bladder Neoplasms 27357429 two types of cancer showed opposite expression patterns for miR-200 family miRNAs -tissue_expression_ns hsa-mir-200c "Carcinoma, Renal Cell" 27357429 two types of cancer showed opposite expression patterns for miR-200 family miRNAs -tissue_expression_ns hsa-mir-148a Neoplasms [unspecific] 27390598 Mir-148a is aberrantly expressed in various cancers and has been identified as an oncogenic or tumor suppressor with crucial roles in the molecular mechanisms of oncogenesis. -tissue_expression_ns hsa-let-7 "Adenocarcinoma, Gastric" 27422560 The integrated analysis of miRNA and gene expression profiles showed the let-7 miRNA family playing a central role in the regulatory relationships. -tissue_expression_ns hsa-let-7c "Adenocarcinoma, Gastric" 27422560 "The miRNAs 100, let-7c, 125b and 99a stood out for their association with the diffuse histological subtype." -tissue_expression_ns hsa-mir-10a Breast Neoplasms 27433802 "We identified eight microRNAs (miR-10a, miR-10b, miR-21, miR-124, miR-125b, miR-126, miR-145 and miR-200a) to be associated with DMBA-induced mammary tumor progression." -tissue_expression_ns hsa-mir-10b Breast Neoplasms 27433802 "We identified eight microRNAs (miR-10a, miR-10b, miR-21, miR-124, miR-125b, miR-126, miR-145 and miR-200a) to be associated with DMBA-induced mammary tumor progression." -tissue_expression_ns hsa-mir-124 Breast Neoplasms 27433802 "We identified eight microRNAs (miR-10a, miR-10b, miR-21, miR-124, miR-125b, miR-126, miR-145 and miR-200a) to be associated with DMBA-induced mammary tumor progression." -tissue_expression_ns hsa-mir-125b Breast Neoplasms 27433802 "We identified eight microRNAs (miR-10a, miR-10b, miR-21, miR-124, miR-125b, miR-126, miR-145 and miR-200a) to be associated with DMBA-induced mammary tumor progression." -tissue_expression_ns hsa-mir-126 Breast Neoplasms 27433802 "We identified eight microRNAs (miR-10a, miR-10b, miR-21, miR-124, miR-125b, miR-126, miR-145 and miR-200a) to be associated with DMBA-induced mammary tumor progression." -tissue_expression_ns hsa-mir-145 Breast Neoplasms 27433802 "We identified eight microRNAs (miR-10a, miR-10b, miR-21, miR-124, miR-125b, miR-126, miR-145 and miR-200a) to be associated with DMBA-induced mammary tumor progression." -tissue_expression_ns hsa-mir-21 Breast Neoplasms 27433802 "We identified eight microRNAs (miR-10a, miR-10b, miR-21, miR-124, miR-125b, miR-126, miR-145 and miR-200a) to be associated with DMBA-induced mammary tumor progression." -tissue_expression_ns hsa-mir-375 "Squamous Cell Carcinoma, Head and Neck" 27440205 Primary HNSCC carcinoma tissues can be distinguished from histologically normal-matched noncancerous tumour-adjacent tissues based on hsa-miR-375-3p expression. -tissue_expression_ns hsa-mir-210 Bladder Neoplasms 27441495 "High miR-210 may reflect hypoxia in bladder cancer. However, its ability to predict benefit from hypoxia modification does not improve upon other hypoxia markers. Investigation as part of a miRNA hypoxia signature may reveal the full potential of miR-210." -tissue_expression_ns hsa-mir-212 Schizophrenia 27468165 "miR-132, miR-133a and miR-212 were initially identified as differentially expressed in BP, miR-184 in MDD and miR-34a in both MDD and BP (although none survived multiple correction testing and must be considered preliminary)." -tissue_expression_ns hsa-mir-200c Melanoma 27469124 miR expression profiles can be measured in indeterminate Spitz tumors and correlate with markers of malignant potential. -tissue_expression_ns hsa-mir-221 Breast Neoplasms 27488105 "An increase in miR-221/222 might be an important event for in situ carcinoma formation, and miR-221/222 may be important molecules that highlight potential differences between invasive breast carcinomas associated with non-invasive and pure invasive BCs." -tissue_expression_ns hsa-mir-222 Breast Neoplasms 27488105 "An increase in miR-221/222 might be an important event for in situ carcinoma formation, and miR-221/222 may be important molecules that highlight potential differences between invasive breast carcinomas associated with non-invasive and pure invasive BCs." -tissue_expression_ns hsa-mir-138 "Carcinoma, Thyroid, Follicular" 27547222 Expression of miRNA and Occurrence of Distant Metastases in Patients with H¨¹rthle Cell Carcinoma. -tissue_expression_ns hsa-mir-1285 "Carcinoma, Hepatocellular" 27554417 Diagnosis of HCC for patients with cirrhosis using miRNA profiles of the tumor-surrounding tissue - A statistical model based on stepwise penalized logistic regression. -tissue_expression_ns hsa-mir-943 "Carcinoma, Hepatocellular" 27554417 Diagnosis of HCC for patients with cirrhosis using miRNA profiles of the tumor-surrounding tissue - A statistical model based on stepwise penalized logistic regression. -tissue_expression_ns hsa-let-7b Crohn Disease 27556489 Mucosal MicroRNAs Expression Profiles before and after Exclusive Enteral Nutrition Therapy in Adult Patients with Crohn's Disease. -tissue_expression_ns hsa-mir-124 Crohn Disease 27556489 Mucosal MicroRNAs Expression Profiles before and after Exclusive Enteral Nutrition Therapy in Adult Patients with Crohn's Disease. -tissue_expression_ns hsa-mir-192 Crohn Disease 27556489 Mucosal MicroRNAs Expression Profiles before and after Exclusive Enteral Nutrition Therapy in Adult Patients with Crohn's Disease. -tissue_expression_ns hsa-mir-301a Crohn Disease 27556489 Mucosal MicroRNAs Expression Profiles before and after Exclusive Enteral Nutrition Therapy in Adult Patients with Crohn's Disease. -tissue_expression_ns hsa-mir-423 Crohn Disease 27556489 Mucosal MicroRNAs Expression Profiles before and after Exclusive Enteral Nutrition Therapy in Adult Patients with Crohn's Disease. -tissue_expression_ns hsa-mir-495 Crohn Disease 27556489 Mucosal MicroRNAs Expression Profiles before and after Exclusive Enteral Nutrition Therapy in Adult Patients with Crohn's Disease. -tissue_expression_ns hsa-mir-99a Crohn Disease 27556489 Mucosal MicroRNAs Expression Profiles before and after Exclusive Enteral Nutrition Therapy in Adult Patients with Crohn's Disease. -tissue_expression_ns hsa-mir-146a Psoriasis 27562321 MicroRNA-146a and miR-99a are potential biomarkers for disease activity and clinical efficacy assessment in psoriasis patients treated with traditional Chinese medicine. -tissue_expression_ns hsa-mir-99a Psoriasis 27562321 MicroRNA-146a and miR-99a are potential biomarkers for disease activity and clinical efficacy assessment in psoriasis patients treated with traditional Chinese medicine. -tissue_expression_ns hsa-mir-146a Uveal Melanoma 27565163 Expression of natural killer cell regulatory microRNA by uveal melanoma cancer stem cells. -tissue_expression_ns hsa-mir-155 Melanoma 27565163 Expression of natural killer cell regulatory microRNA by uveal melanoma cancer stem cells. -tissue_expression_ns hsa-mir-200c Colorectal Carcinoma 27565378 "Investigating intra-tumor heterogeneity and expression gradients of miR-21, miR-92a and miR-200c and their potential of predicting lymph node metastases in early colorectal cancer." -tissue_expression_ns hsa-mir-21 Colorectal Carcinoma 27565378 "Investigating intra-tumor heterogeneity and expression gradients of miR-21, miR-92a and miR-200c and their potential of predicting lymph node metastases in early colorectal cancer." -tissue_expression_ns hsa-mir-92a Colorectal Carcinoma 27565378 "Investigating intra-tumor heterogeneity and expression gradients of miR-21, miR-92a and miR-200c and their potential of predicting lymph node metastases in early colorectal cancer." -tissue_expression_ns hsa-mir-574 "Squamous Cell Carcinoma, Esophageal" 27565418 The expression of microRNA 574-3p as a predictor of postoperative outcome in patients with esophageal squamous cell carcinoma. -tissue_expression_ns hsa-mir-125b Melanoma 27566021 MicroRNA dysregulation in melanoma. -tissue_expression_ns hsa-mir-150 Melanoma 27566021 MicroRNA dysregulation in melanoma. -tissue_expression_ns hsa-mir-155 Melanoma 27566021 MicroRNA dysregulation in melanoma. -tissue_expression_ns hsa-mir-205 Melanoma 27566021 MicroRNA dysregulation in melanoma. -tissue_expression_ns hsa-mir-21 Melanoma 27566021 MicroRNA dysregulation in melanoma. -tissue_expression_ns hsa-mir-211 Melanoma 27566021 MicroRNA dysregulation in melanoma. -tissue_expression_ns hsa-mir-1247 Glioblastoma 27572852 "Several crucial genes, TFs, miRNAs and small molecules in the different GBM subgroups were identified, which may be used as potential markers" -tissue_expression_ns hsa-mir-147b Glioblastoma 27572852 "Several crucial genes, TFs, miRNAs and small molecules in the different GBM subgroups were identified, which may be used as potential markers" -tissue_expression_ns hsa-mir-220a Glioblastoma 27572852 "miR-147b, miR-770-5p, miR-220a and miR-1247 were the particular miRNAs in subgroups?1-4" -tissue_expression_ns hsa-mir-770 Glioblastoma 27572852 "Several crucial genes, TFs, miRNAs and small molecules in the different GBM subgroups were identified, which may be used as potential markers" -tissue_expression_ns hsa-mir-146b Aortic Stenosis 27579316 MicroRNA Expression Signature in Degenerative Aortic Stenosis. -tissue_expression_ns hsa-mir-193a Aortic Stenosis 27579316 MicroRNA Expression Signature in Degenerative Aortic Stenosis. -tissue_expression_ns hsa-mir-194 Aortic Stenosis 27579316 MicroRNA Expression Signature in Degenerative Aortic Stenosis. -tissue_expression_ns hsa-mir-1972 Aortic Stenosis 27579316 MicroRNA Expression Signature in Degenerative Aortic Stenosis. -tissue_expression_ns hsa-mir-200b Aortic Stenosis 27579316 MicroRNA Expression Signature in Degenerative Aortic Stenosis. -tissue_expression_ns hsa-mir-21 Aortic Stenosis 27579316 MicroRNA Expression Signature in Degenerative Aortic Stenosis. -tissue_expression_ns hsa-mir-29b Aortic Stenosis 27579316 MicroRNA Expression Signature in Degenerative Aortic Stenosis. -tissue_expression_ns hsa-mir-301a Aortic Stenosis 27579316 MicroRNA Expression Signature in Degenerative Aortic Stenosis. -tissue_expression_ns hsa-mir-3138 Aortic Stenosis 27579316 MicroRNA Expression Signature in Degenerative Aortic Stenosis. -tissue_expression_ns hsa-mir-34a Aortic Stenosis 27579316 MicroRNA Expression Signature in Degenerative Aortic Stenosis. -tissue_expression_ns hsa-mir-3663 Aortic Stenosis 27579316 MicroRNA Expression Signature in Degenerative Aortic Stenosis. -tissue_expression_ns hsa-mir-505 Aortic Stenosis 27579316 MicroRNA Expression Signature in Degenerative Aortic Stenosis. -tissue_expression_ns hsa-mir-513a Aortic Stenosis 27579316 MicroRNA Expression Signature in Degenerative Aortic Stenosis. -tissue_expression_ns hsa-mir-516a Aortic Stenosis 27579316 MicroRNA Expression Signature in Degenerative Aortic Stenosis. -tissue_expression_ns hsa-mir-575 Aortic Stenosis 27579316 MicroRNA Expression Signature in Degenerative Aortic Stenosis. -tissue_expression_ns hsa-mir-630 Aortic Stenosis 27579316 MicroRNA Expression Signature in Degenerative Aortic Stenosis. -tissue_expression_ns hsa-mir-636 Aortic Stenosis 27579316 MicroRNA Expression Signature in Degenerative Aortic Stenosis. -tissue_expression_ns hsa-mir-718 Aortic Stenosis 27579316 MicroRNA Expression Signature in Degenerative Aortic Stenosis. -tissue_expression_ns hsa-mir-99b Aortic Stenosis 27579316 MicroRNA Expression Signature in Degenerative Aortic Stenosis. -tissue_expression_ns hsa-mir-100 "Carcinoma, Bladder" 27586262 microRNA expression profiles as decision-making biomarkers in the management of bladder cancer. -tissue_expression_ns hsa-mir-146b "Carcinoma, Bladder" 27586262 microRNA expression profiles as decision-making biomarkers in the management of bladder cancer. -tissue_expression_ns hsa-mir-193a "Carcinoma, Bladder" 27586262 microRNA expression profiles as decision-making biomarkers in the management of bladder cancer. -tissue_expression_ns hsa-mir-34 "Carcinoma, Bladder" 27586262 microRNA expression profiles as decision-making biomarkers in the management of bladder cancer. -tissue_expression_ns hsa-mir-9 "Carcinoma, Bladder" 27586262 microRNA expression profiles as decision-making biomarkers in the management of bladder cancer. -tissue_expression_ns hsa-mir-92b "Carcinoma, Rectal" 27601590 Genome-Wide miRNA Analysis Identifies miR-188-3p as a Novel Prognostic Marker and Molecular Factor Involved in Colorectal Carcinogenesis. -tissue_expression_ns hsa-mir-33b "Squamous Cell Carcinoma, Esophageal" 27609581 The expression and significance of miR-33b and HMGA2 in esophageal squamous cell carcinoma. -tissue_expression_ns hsa-let-7a Neoplasms [unspecific] 27623940 Aberrant microRNA expression in tumor mycosis fungoides. -tissue_expression_ns hsa-mir-1267 Neoplasms [unspecific] 27623940 Aberrant microRNA expression in tumor mycosis fungoides. -tissue_expression_ns hsa-mir-1282 Neoplasms [unspecific] 27623940 Aberrant microRNA expression in tumor mycosis fungoides. -tissue_expression_ns hsa-mir-200c Neoplasms [unspecific] 27623940 Aberrant microRNA expression in tumor mycosis fungoides. -tissue_expression_ns hsa-mir-210 Neoplasms [unspecific] 27623940 Aberrant microRNA expression in tumor mycosis fungoides. -tissue_expression_ns hsa-mir-29a Neoplasms [unspecific] 27623940 Aberrant microRNA expression in tumor mycosis fungoides. -tissue_expression_ns hsa-mir-3177 Neoplasms [unspecific] 27623940 Aberrant microRNA expression in tumor mycosis fungoides. -tissue_expression_ns hsa-mir-34a Neoplasms [unspecific] 27623940 Aberrant microRNA expression in tumor mycosis fungoides. -tissue_expression_ns hsa-mir-514b Neoplasms [unspecific] 27623940 Aberrant microRNA expression in tumor mycosis fungoides. -tissue_expression_ns hsa-mir-221 "Carcinoma, Prostate" 27630329 "to evaluate miR-23b, miR-26a and miR-221 expression levels in combination with preoperative serum PSA level to the risk of PCa recurrence after radical prostatectomy" -tissue_expression_ns hsa-mir-23b "Carcinoma, Prostate" 27630329 "to evaluate miR-23b, miR-26a and miR-221 expression levels in combination with preoperative serum PSA level to the risk of PCa recurrence after radical prostatectomy" -tissue_expression_ns hsa-mir-26a "Carcinoma, Prostate" 27630329 "to evaluate miR-23b, miR-26a and miR-221 expression levels in combination with preoperative serum PSA level to the risk of PCa recurrence after radical prostatectomy" -tissue_expression_ns hsa-mir-100 "Carcinoma, Bladder" 27631180 Evaluation of miR-182/miR-100 Ratio for Diagnosis and Survival Prediction in Bladder Cancer. -tissue_expression_ns hsa-mir-182 "Carcinoma, Bladder" 27631180 Evaluation of miR-182/miR-100 Ratio for Diagnosis and Survival Prediction in Bladder Cancer. -tissue_expression_ns hsa-mir-143 Atherosclerosis 27631489 Differential Expression of MicroRNAs in Endarterectomy Specimens Taken from Patients with Asymptomatic and Symptomatic Carotid Plaques. -tissue_expression_ns hsa-mir-21 Atherosclerosis 27631489 Differential Expression of MicroRNAs in Endarterectomy Specimens Taken from Patients with Asymptomatic and Symptomatic Carotid Plaques. -tissue_expression_ns hsa-mir-195 Muscular Dystrophy 27651778 "At the epigenetic level, miRNAs are thought to be highly involved in the pathophysiological progress of denervated muscles" -tissue_expression_ns hsa-mir-214 Muscular Dystrophy 27651778 "At the epigenetic level, miRNAs are thought to be highly involved in the pathophysiological progress of denervated muscles" -tissue_expression_ns hsa-mir-221 Muscular Dystrophy 27651778 "At the epigenetic level, miRNAs are thought to be highly involved in the pathophysiological progress of denervated muscles" -tissue_expression_ns hsa-mir-222 Muscular Dystrophy 27651778 "At the epigenetic level, miRNAs are thought to be highly involved in the pathophysiological progress of denervated muscles" -tissue_expression_ns hsa-mir-320 Muscular Dystrophy 27651778 "At the epigenetic level, miRNAs are thought to be highly involved in the pathophysiological progress of denervated muscles" -tissue_expression_ns hsa-mir-222 Breast Neoplasms 27659519 Profiles of miRNAs matched to biology in aromatase inhibitor resistant breast cancer. -tissue_expression_ns hsa-mir-31 Breast Neoplasms 27659519 Profiles of miRNAs matched to biology in aromatase inhibitor resistant breast cancer. -tissue_expression_ns hsa-mir-126 "Carcinoma, Lung, Non-Small-Cell" 27665734 Matrine induces cell cycle arrest and apoptosis with recovery of the expression of miR-126 in the A549 non-small cell lung cancer cell line. -tissue_expression_ns hsa-mir-151a "Carcinoma, Thyroid, Medullary" 27666315 Selection and validation of miRNAs as normalizers for profiling expression of microRNAs isolated from thyroid fine needle aspiration smears. -tissue_expression_ns hsa-mir-197 "Carcinoma, Thyroid, Medullary" 27666315 Selection and validation of miRNAs as normalizers for profiling expression of microRNAs isolated from thyroid fine needle aspiration smears. -tissue_expression_ns hsa-mir-214 "Carcinoma, Thyroid, Medullary" 27666315 Selection and validation of miRNAs as normalizers for profiling expression of microRNAs isolated from thyroid fine needle aspiration smears. -tissue_expression_ns hsa-mir-99a "Carcinoma, Thyroid, Medullary" 27666315 Selection and validation of miRNAs as normalizers for profiling expression of microRNAs isolated from thyroid fine needle aspiration smears. -tissue_expression_ns hsa-mir-27a Down Syndrome 27666924 Integrated microRNA and protein expression analysis reveals novel microRNA regulation of targets in fetal down syndrome. -tissue_expression_ns hsa-mir-27b Down Syndrome 27666924 Integrated microRNA and protein expression analysis reveals novel microRNA regulation of targets in fetal down syndrome. -tissue_expression_ns hsa-mir-329 Down Syndrome 27666924 Integrated microRNA and protein expression analysis reveals novel microRNA regulation of targets in fetal down syndrome. -tissue_expression_ns hsa-mir-135b Colorectal Carcinoma 27672263 "MicroRNA biomarkers predicting risk, initiation and progression of colorectal cancer." -tissue_expression_ns hsa-mir-18a Colorectal Carcinoma 27672263 "MicroRNA biomarkers predicting risk, initiation and progression of colorectal cancer." -tissue_expression_ns hsa-mir-21 Colorectal Carcinoma 27672263 "MicroRNA biomarkers predicting risk, initiation and progression of colorectal cancer." -tissue_expression_ns hsa-mir-601 Colorectal Carcinoma 27672263 "MicroRNA biomarkers predicting risk, initiation and progression of colorectal cancer." -tissue_expression_ns hsa-mir-760 Colorectal Carcinoma 27672263 "MicroRNA biomarkers predicting risk, initiation and progression of colorectal cancer." -tissue_expression_ns hsa-mir-92a Colorectal Carcinoma 27672263 "MicroRNA biomarkers predicting risk, initiation and progression of colorectal cancer." -tissue_expression_ns hsa-mir-155 Liver Injury 27673475 Fine-tuning the expression of microRNA-155 controls acetaminophen-induced liver inflammation. -tissue_expression_ns hsa-mir-122 "Diabetes Mellitus, Type 2" 27681254 Differentially expressed microRNAs in the corpus cavernosum from a murine model with type 2 diabetes mellitus-associated erectile dysfunction. -tissue_expression_ns hsa-mir-133 "Diabetes Mellitus, Type 2" 27681254 Differentially expressed microRNAs in the corpus cavernosum from a murine model with type 2 diabetes mellitus-associated erectile dysfunction. -tissue_expression_ns hsa-mir-18a "Diabetes Mellitus, Type 2" 27681254 Differentially expressed microRNAs in the corpus cavernosum from a murine model with type 2 diabetes mellitus-associated erectile dysfunction. -tissue_expression_ns hsa-mir-206 "Diabetes Mellitus, Type 2" 27681254 Differentially expressed microRNAs in the corpus cavernosum from a murine model with type 2 diabetes mellitus-associated erectile dysfunction. -tissue_expression_ns hsa-mir-10b Obesity 27682205 Impact of endurance exercise training on adipocyte microRNA expression in overweight men. -tissue_expression_ns hsa-mir-204 Obesity 27682205 Impact of endurance exercise training on adipocyte microRNA expression in overweight men. -tissue_expression_ns hsa-mir-3613 Obesity 27682205 Impact of endurance exercise training on adipocyte microRNA expression in overweight men. -tissue_expression_ns hsa-mir-4532 Obesity 27682205 Impact of endurance exercise training on adipocyte microRNA expression in overweight men. -tissue_expression_ns hsa-mir-155 "Carcinoma, Lung, Small-Cell" 27682492 Changes of microRNAs profiling in mesothelial cells exposed to multi-walled carbon nanotubes. -tissue_expression_ns hsa-mir-28 "Carcinoma, Lung, Small-Cell" 27682492 Changes of microRNAs profiling in mesothelial cells exposed to multi-walled carbon nanotubes. -tissue_expression_ns hsa-mir-30 "Carcinoma, Lung, Small-Cell" 27682492 Changes of microRNAs profiling in mesothelial cells exposed to multi-walled carbon nanotubes. -tissue_expression_ns hsa-mir-324 "Carcinoma, Lung, Small-Cell" 27682492 Changes of microRNAs profiling in mesothelial cells exposed to multi-walled carbon nanotubes. -tissue_expression_ns hsa-mir-34c "Carcinoma, Lung, Small-Cell" 27682492 Changes of microRNAs profiling in mesothelial cells exposed to multi-walled carbon nanotubes. -tissue_expression_ns hsa-mir-18a Lung Fibrosis 27689473 Altered microRNA expression profiles in lung damage induced by nanosized SiO2. -tissue_expression_ns hsa-mir-212 Lung Fibrosis 27689473 Altered microRNA expression profiles in lung damage induced by nanosized SiO2. -tissue_expression_ns hsa-mir-128a Mesial Temporal Lobe Epilepsy 27695061 Identification of microRNAs with Dysregulated Expression in Status Epilepticus Induced Epileptogenesis. -tissue_expression_ns hsa-mir-196b Mesial Temporal Lobe Epilepsy 27695061 Identification of microRNAs with Dysregulated Expression in Status Epilepticus Induced Epileptogenesis. -tissue_expression_ns hsa-mir-352 Mesial Temporal Lobe Epilepsy 27695061 Identification of microRNAs with Dysregulated Expression in Status Epilepticus Induced Epileptogenesis. -tissue_expression_ns hsa-mir-31 "Adenocarcinoma, Lung" 27695346 MicroRNA expression profiles predict progression and clinical outcome in lung adenocarcinoma. -tissue_expression_ns hsa-mir-1238 Chronic Brucellosis 27722176 "Altered Expressions of miR-1238-3p, miR-494, miR-6069, and miR-139-3p in the Formation of Chronic Brucellosis." -tissue_expression_ns hsa-mir-139 Chronic Brucellosis 27722176 "Altered Expressions of miR-1238-3p, miR-494, miR-6069, and miR-139-3p in the Formation of Chronic Brucellosis." -tissue_expression_ns hsa-mir-494 Chronic Brucellosis 27722176 "Altered Expressions of miR-1238-3p, miR-494, miR-6069, and miR-139-3p in the Formation of Chronic Brucellosis." -tissue_expression_ns hsa-mir-6069 Chronic Brucellosis 27722176 "Altered Expressions of miR-1238-3p, miR-494, miR-6069, and miR-139-3p in the Formation of Chronic Brucellosis." -tissue_expression_ns hsa-mir-200 Cardiomyopathy 27737314 Analyzing gene expression profiles in dilated cardiomyopathy via bioinformatics methods. -tissue_expression_ns hsa-mir-30 Cardiomyopathy 27737314 Analyzing gene expression profiles in dilated cardiomyopathy via bioinformatics methods. -tissue_expression_ns hsa-mir-9 Cardiomyopathy 27737314 Analyzing gene expression profiles in dilated cardiomyopathy via bioinformatics methods. -tissue_expression_ns hsa-mir-146a Diabetes Mellitus 27743454 "we present an overview of the roles of miRNAs in the islet ¦Â-cell development, focusing on the application of different miRNAs in the experimental protocols" -tissue_expression_ns hsa-mir-200 Diabetes Mellitus 27743454 The role of microRNAs in islet ¦Â-cell development. -tissue_expression_ns hsa-mir-30 Diabetes Mellitus 27743454 The role of microRNAs in islet ¦Â-cell development. -tissue_expression_ns hsa-mir-342 Diabetes Mellitus 27743454 The role of microRNAs in islet ¦Â-cell development. -tissue_expression_ns hsa-mir-34a Diabetes Mellitus 27743454 The role of microRNAs in islet ¦Â-cell development. -tissue_expression_ns hsa-mir-375 Diabetes Mellitus 27743454 The role of microRNAs in islet ¦Â-cell development. -tissue_expression_ns hsa-mir-7 Diabetes Mellitus 27743454 The role of microRNAs in islet ¦Â-cell development. -tissue_expression_ns hsa-mir-1246 "Carcinoma, Breast" 27746365 This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients -tissue_expression_ns hsa-mir-1268a "Carcinoma, Breast" 27746365 This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients -tissue_expression_ns hsa-mir-130a "Carcinoma, Breast" 27746365 This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients -tissue_expression_ns hsa-mir-138 "Carcinoma, Breast" 27746365 This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients -tissue_expression_ns hsa-mir-139 "Carcinoma, Breast" 27746365 This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients -tissue_expression_ns hsa-mir-197 "Carcinoma, Breast" 27746365 This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients -tissue_expression_ns hsa-mir-200b "Carcinoma, Breast" 27746365 This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients -tissue_expression_ns hsa-mir-210 "Carcinoma, Breast" 27746365 This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients -tissue_expression_ns hsa-mir-3613 "Carcinoma, Breast" 27746365 This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients -tissue_expression_ns hsa-mir-4258 "Carcinoma, Breast" 27746365 This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients -tissue_expression_ns hsa-mir-4298 "Carcinoma, Breast" 27746365 This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients -tissue_expression_ns hsa-mir-452 "Carcinoma, Breast" 27746365 This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients -tissue_expression_ns hsa-mir-4644 "Carcinoma, Breast" 27746365 This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients -tissue_expression_ns hsa-mir-671 "Carcinoma, Breast" 27746365 This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients -tissue_expression_ns hsa-mir-7107 "Carcinoma, Breast" 27746365 This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients -tissue_expression_ns hsa-mir-7847 "Carcinoma, Breast" 27746365 This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients -tissue_expression_ns hsa-mir-90b "Carcinoma, Breast" 27746365 This study highlights the role of numerous miRNAs in prediction of therapeutic responses and suggests that specific miRNAs could serve as valuable sources for biomarker detections and optimal chemotherapeutic choices for breast cancer patients -tissue_expression_ns hsa-mir-192 Colorectal Carcinoma 27747302 "high miR-192 and miR-194 correlate with better overall survival in Stage II patients, but worse survival in more advanced Stage III/IV patients" -tissue_expression_ns hsa-mir-194 Colorectal Carcinoma 27747302 "high miR-192 and miR-194 correlate with better overall survival in Stage II patients, but worse survival in more advanced Stage III/IV patients" -tissue_expression_ns hsa-mir-1244 Borna Disease 27748825 Identification and bioinformatic analysis of dysregulated microRNAs in human oligodendroglial cells infected with borna disease virus. -tissue_expression_ns hsa-mir-1290 Borna Disease 27748825 Identification and bioinformatic analysis of dysregulated microRNAs in human oligodendroglial cells infected with borna disease virus. -tissue_expression_ns hsa-mir-146a Borna Disease 27748825 Identification and bioinformatic analysis of dysregulated microRNAs in human oligodendroglial cells infected with borna disease virus. -tissue_expression_ns hsa-mir-1908 Borna Disease 27748825 Identification and bioinformatic analysis of dysregulated microRNAs in human oligodendroglial cells infected with borna disease virus. -tissue_expression_ns hsa-mir-296 Borna Disease 27748825 Identification and bioinformatic analysis of dysregulated microRNAs in human oligodendroglial cells infected with borna disease virus. -tissue_expression_ns hsa-mir-3676 Borna Disease 27748825 Identification and bioinformatic analysis of dysregulated microRNAs in human oligodendroglial cells infected with borna disease virus. -tissue_expression_ns hsa-mir-424 Borna Disease 27748825 Identification and bioinformatic analysis of dysregulated microRNAs in human oligodendroglial cells infected with borna disease virus. -tissue_expression_ns hsa-mir-4521 Borna Disease 27748825 Identification and bioinformatic analysis of dysregulated microRNAs in human oligodendroglial cells infected with borna disease virus. -tissue_expression_ns hsa-mir-7 Borna Disease 27748825 Identification and bioinformatic analysis of dysregulated microRNAs in human oligodendroglial cells infected with borna disease virus. -tissue_expression_ns hsa-mir-449a "Carcinoma, Breast" 27748845 MicroRNA profiling in human breast cancer cell lines exposed to the anti-neoplastic drug cediranib. -tissue_expression_ns hsa-mir-449b "Carcinoma, Breast" 27748845 MicroRNA profiling in human breast cancer cell lines exposed to the anti-neoplastic drug cediranib. -tissue_expression_ns hsa-mir-494 "Carcinoma, Breast" 27748845 MicroRNA profiling in human breast cancer cell lines exposed to the anti-neoplastic drug cediranib. -tissue_expression_ns hsa-mir-886 "Carcinoma, Breast" 27748845 MicroRNA profiling in human breast cancer cell lines exposed to the anti-neoplastic drug cediranib. -tissue_expression_ns hsa-mir-923 "Carcinoma, Breast" 27748845 MicroRNA profiling in human breast cancer cell lines exposed to the anti-neoplastic drug cediranib. -tissue_expression_ns hsa-mir-125a "Carcinoma, Lung" 27748875 MicroRNA expression profiles of granulocytic myeloid?derived suppressor cells from mice bearing Lewis lung carcinoma. -tissue_expression_ns hsa-mir-125b "Carcinoma, Lung" 27748875 MicroRNA expression profiles of granulocytic myeloid?derived suppressor cells from mice bearing Lewis lung carcinoma. -tissue_expression_ns hsa-mir-128 "Carcinoma, Lung" 27748875 MicroRNA expression profiles of granulocytic myeloid?derived suppressor cells from mice bearing Lewis lung carcinoma. -tissue_expression_ns hsa-mir-149 "Carcinoma, Lung" 27748875 MicroRNA expression profiles of granulocytic myeloid?derived suppressor cells from mice bearing Lewis lung carcinoma. -tissue_expression_ns hsa-mir-192 "Carcinoma, Lung" 27748875 MicroRNA expression profiles of granulocytic myeloid?derived suppressor cells from mice bearing Lewis lung carcinoma. -tissue_expression_ns hsa-mir-27a "Carcinoma, Lung" 27748875 MicroRNA expression profiles of granulocytic myeloid?derived suppressor cells from mice bearing Lewis lung carcinoma. -tissue_expression_ns hsa-mir-328 "Carcinoma, Lung" 27748875 MicroRNA expression profiles of granulocytic myeloid?derived suppressor cells from mice bearing Lewis lung carcinoma. -tissue_expression_ns hsa-mir-350 "Carcinoma, Lung" 27748875 MicroRNA expression profiles of granulocytic myeloid?derived suppressor cells from mice bearing Lewis lung carcinoma. -tissue_expression_ns hsa-mir-486 "Carcinoma, Lung" 27748875 MicroRNA expression profiles of granulocytic myeloid?derived suppressor cells from mice bearing Lewis lung carcinoma. -tissue_expression_ns hsa-mir-143 "Carcinoma, Ovarian" 27748916 Dysregulation of micro-143-3p and BALBP1 contributes to the pathogenesis of the development of ovarian carcinoma. -tissue_expression_ns hsa-let-7 Schizophrenia 27748930 "the possible role of let-7, miR-98 and miR-183 as biomarkers for Ca and SZ was investigated in our previous research studies" -tissue_expression_ns hsa-mir-183 Schizophrenia 27748930 "the possible role of let-7, miR-98 and miR-183 as biomarkers for Ca and SZ was investigated in our previous research studies" -tissue_expression_ns hsa-mir-98 Schizophrenia 27748930 "the possible role of let-7, miR-98 and miR-183 as biomarkers for Ca and SZ was investigated in our previous research studies" -tissue_expression_ns hsa-mir-210 Human Immunodeficiency Virus Infection 27749601 "MicroRNA-210, MicroRNA-331, and MicroRNA-7 Are Differentially Regulated in Treated HIV-1-Infected Individuals and Are Associated With Markers of Systemic Inflammation." -tissue_expression_ns hsa-mir-331 Human Immunodeficiency Virus Infection 27749601 "MicroRNA-210, MicroRNA-331, and MicroRNA-7 Are Differentially Regulated in Treated HIV-1-Infected Individuals and Are Associated With Markers of Systemic Inflammation." -tissue_expression_ns hsa-mir-7 Human Immunodeficiency Virus Infection 27749601 "MicroRNA-210, MicroRNA-331, and MicroRNA-7 Are Differentially Regulated in Treated HIV-1-Infected Individuals and Are Associated With Markers of Systemic Inflammation." -tissue_expression_ns hsa-mir-210 Ischemic Diseases [unspecific] 27750254 Temporal Profile of Circulating microRNAs after Global Hypoxia-Ischemia in Newborn Piglets. -tissue_expression_ns hsa-mir-146a "Carcinoma, Bladder" 27751843 Real-time PCR analysis pointed to miR-375 as a biomarker for high-grade bladder cancer while miR-146a could identify low-grade patients -tissue_expression_ns hsa-mir-375 "Carcinoma, Bladder" 27751843 Real-time PCR analysis pointed to miR-375 as a biomarker for high-grade bladder cancer while miR-146a could identify low-grade patients -tissue_expression_ns hsa-mir-630 "Carcinoma, Urothelial" 27752905 Expression of miRNA-630 in bladder urothelial carcinoma and its clinical significance. -tissue_expression_ns hsa-mir-941 Polyangiitis 27755585 MicroRNA-941 Expression in Polymorphonuclear Granulocytes Is Not Related to Granulomatosis with Polyangiitis. -tissue_expression_ns hsa-mir-381 "Carcinoma, Ovarian" 27757782 Identification of candidate biomarkers and analysis of prognostic values in ovarian cancer by integrated bioinformatics analysis. -tissue_expression_ns hsa-mir-424 "Carcinoma, Ovarian" 27757782 Identification of candidate biomarkers and analysis of prognostic values in ovarian cancer by integrated bioinformatics analysis. -tissue_expression_ns hsa-mir-106b "Carcinoma, Cervical" 27764149 miRNA Expression Profiles of HPV-Infected Patients with Cervical Cancer in the Uyghur Population in China. -tissue_expression_ns hsa-mir-15a "Carcinoma, Cervical" 27764149 miRNA Expression Profiles of HPV-Infected Patients with Cervical Cancer in the Uyghur Population in China. -tissue_expression_ns hsa-mir-17 "Carcinoma, Cervical" 27764149 miRNA Expression Profiles of HPV-Infected Patients with Cervical Cancer in the Uyghur Population in China. -tissue_expression_ns hsa-mir-20a "Carcinoma, Cervical" 27764149 miRNA Expression Profiles of HPV-Infected Patients with Cervical Cancer in the Uyghur Population in China. -tissue_expression_ns hsa-mir-21 "Carcinoma, Cervical" 27764149 miRNA Expression Profiles of HPV-Infected Patients with Cervical Cancer in the Uyghur Population in China. -tissue_expression_ns hsa-mir-3653 "Carcinoma, Cervical" 27764149 miRNA Expression Profiles of HPV-Infected Patients with Cervical Cancer in the Uyghur Population in China. -tissue_expression_ns hsa-mir-497 "Carcinoma, Cervical" 27764149 miRNA Expression Profiles of HPV-Infected Patients with Cervical Cancer in the Uyghur Population in China. -tissue_expression_ns hsa-mir-96 "Carcinoma, Cervical" 27764149 miRNA Expression Profiles of HPV-Infected Patients with Cervical Cancer in the Uyghur Population in China. -tissue_expression_ns hsa-mir-133a Cardiovascular Diseases [unspecific] 27765794 Inhibition of Aberrant MicroRNA-133a Expression in Endothelial Cells by Statin Prevents Endothelial Dysfunction by Targeting GTP Cyclohydrolase 1 in Vivo. -tissue_expression_ns hsa-mir-498 "Squamous Cell Carcinoma, Tongue" 27773646 MicroRNA and protein profiles in invasive versus non-invasive oral tongue squamous cell carcinoma cells in vitro. -tissue_expression_ns hsa-mir-940 "Squamous Cell Carcinoma, Tongue" 27773646 MicroRNA and protein profiles in invasive versus non-invasive oral tongue squamous cell carcinoma cells in vitro. -tissue_expression_ns hsa-mir-129 Amyotrophic Lateral Sclerosis 27773796 MicroRNA expression profiles of multiple system atrophy from formalin-fixed paraffin-embedded samples. -tissue_expression_ns hsa-mir-132 Amyotrophic Lateral Sclerosis 27773796 MicroRNA expression profiles of multiple system atrophy from formalin-fixed paraffin-embedded samples. -tissue_expression_ns hsa-mir-125 Colorectal Carcinoma 27775664 A Comprehensive MicroRNA Expression Profile of Liver and Lung Metastases of Colorectal Cancer with Their Corresponding Host Tissue and Its Prognostic Impact on Survival. -tissue_expression_ns hsa-mir-127 Colorectal Carcinoma 27775664 A Comprehensive MicroRNA Expression Profile of Liver and Lung Metastases of Colorectal Cancer with Their Corresponding Host Tissue and Its Prognostic Impact on Survival. -tissue_expression_ns hsa-mir-145 Colorectal Carcinoma 27775664 A Comprehensive MicroRNA Expression Profile of Liver and Lung Metastases of Colorectal Cancer with Their Corresponding Host Tissue and Its Prognostic Impact on Survival. -tissue_expression_ns hsa-mir-19 Colorectal Carcinoma 27775664 A Comprehensive MicroRNA Expression Profile of Liver and Lung Metastases of Colorectal Cancer with Their Corresponding Host Tissue and Its Prognostic Impact on Survival. -tissue_expression_ns hsa-mir-192 Colorectal Carcinoma 27775664 A Comprehensive MicroRNA Expression Profile of Liver and Lung Metastases of Colorectal Cancer with Their Corresponding Host Tissue and Its Prognostic Impact on Survival. -tissue_expression_ns hsa-mir-194 Colorectal Carcinoma 27775664 A Comprehensive MicroRNA Expression Profile of Liver and Lung Metastases of Colorectal Cancer with Their Corresponding Host Tissue and Its Prognostic Impact on Survival. -tissue_expression_ns hsa-mir-199 Colorectal Carcinoma 27775664 A Comprehensive MicroRNA Expression Profile of Liver and Lung Metastases of Colorectal Cancer with Their Corresponding Host Tissue and Its Prognostic Impact on Survival. -tissue_expression_ns hsa-mir-21 Colorectal Carcinoma 27775664 A Comprehensive MicroRNA Expression Profile of Liver and Lung Metastases of Colorectal Cancer with Their Corresponding Host Tissue and Its Prognostic Impact on Survival. -tissue_expression_ns hsa-mir-215 Colorectal Carcinoma 27775664 A Comprehensive MicroRNA Expression Profile of Liver and Lung Metastases of Colorectal Cancer with Their Corresponding Host Tissue and Its Prognostic Impact on Survival. -tissue_expression_ns hsa-mir-429 Colorectal Carcinoma 27775664 A Comprehensive MicroRNA Expression Profile of Liver and Lung Metastases of Colorectal Cancer with Their Corresponding Host Tissue and Its Prognostic Impact on Survival. -tissue_expression_ns hsa-mir-143 Inflammation 27776879 Expression Profiles of Inflammation-associated microRNAs in Periapical Lesions and Human Periodontal Ligament Fibroblasts Inflammation. -tissue_expression_ns hsa-mir-223 Polycystic Ovarian Syndrome 27777110 Altered expression of miRNAs in the uterus from a letrozole-induced rat PCOS model. -tissue_expression_ns hsa-mir-324 Polycystic Ovarian Syndrome 27777110 Altered expression of miRNAs in the uterus from a letrozole-induced rat PCOS model. -tissue_expression_ns hsa-mir-375 Polycystic Ovarian Syndrome 27777110 Altered expression of miRNAs in the uterus from a letrozole-induced rat PCOS model. -tissue_expression_ns hsa-mir-484 Polycystic Ovarian Syndrome 27777110 Altered expression of miRNAs in the uterus from a letrozole-induced rat PCOS model. -tissue_expression_ns hsa-mir-152 Colorectal Carcinoma 27784461 Expression of microRNA-152 in colorectal cancer and its relationship with prognosis. -tissue_expression_ns hsa-let-7d Reproductive System Disease 27789200 "A number of these differentially expressed miRNAs have previously been associated with adipogenesis(e.g. let-7d*, miR-103-2*, -130b, -146b-5-p, -29c, and -26b)" -tissue_expression_ns hsa-mir-103-2 Reproductive System Disease 27789200 "A number of these differentially expressed miRNAs have previously been associated with adipogenesis(e.g. let-7d*, miR-103-2*, -130b, -146b-5-p, -29c, and -26b)" -tissue_expression_ns hsa-mir-130b Reproductive System Disease 27789200 "A number of these differentially expressed miRNAs have previously been associated with adipogenesis(e.g. let-7d*, miR-103-2*, -130b, -146b-5-p, -29c, and -26b)" -tissue_expression_ns hsa-mir-146b Reproductive System Disease 27789200 "A number of these differentially expressed miRNAs have previously been associated with adipogenesis(e.g. let-7d*, miR-103-2*, -130b, -146b-5-p, -29c, and -26b)" -tissue_expression_ns hsa-mir-26b Reproductive System Disease 27789200 "A number of these differentially expressed miRNAs have previously been associated with adipogenesis(e.g. let-7d*, miR-103-2*, -130b, -146b-5-p, -29c, and -26b)" -tissue_expression_ns hsa-mir-29c Reproductive System Disease 27789200 "A number of these differentially expressed miRNAs have previously been associated with adipogenesis(e.g. let-7d*, miR-103-2*, -130b, -146b-5-p, -29c, and -26b)" -tissue_expression_ns hsa-mir-323a Epilepsy 27824513 Aberrant Expression of miR-323a-5p in Patients with Refractory Epilepsy Caused by Focal Cortical Dysplasia. -tissue_expression_ns hsa-mir-9 Cerebral Aneurysm 27824808 Aberrant Expression of microRNA-9 Contributes to Development of Intracranial Aneurysm by Suppressing Proliferation and Reducing Contractility of Smooth Muscle Cells. -tissue_expression_ns hsa-mir-1 Vascular Hypertrophy 27831640 Influence and significance of intervening diabetes microRNA expression profile of NOD mice with exendin-4. -tissue_expression_ns hsa-let-7a Squamous Cell Carcinoma 27835588 Expressions of miR-30c and let-7a are inversely correlated with HMGA2 expression in squamous cell carcinoma of the vulva. -tissue_expression_ns hsa-mir-4717 Guillain-Barre Syndrome 27836180 MicroRNA expression profiling in Guillain-Barr¨¦ syndrome. -tissue_expression_ns hsa-mir-642b Guillain-Barre Syndrome 27836180 MicroRNA expression profiling in Guillain-Barr¨¦ syndrome. -tissue_expression_ns hsa-mir-155 "Carcinoma, Pancreatic" 27840954 Identfication of key miRNAs in pancreatitis using bioinformatics analysis of microarray data. -tissue_expression_ns hsa-mir-15a "Carcinoma, Pancreatic" 27840954 Identfication of key miRNAs in pancreatitis using bioinformatics analysis of microarray data. -tissue_expression_ns hsa-mir-16 "Carcinoma, Pancreatic" 27840954 Identfication of key miRNAs in pancreatitis using bioinformatics analysis of microarray data. -tissue_expression_ns hsa-mir-375 "Carcinoma, Pancreatic" 27840954 Identfication of key miRNAs in pancreatitis using bioinformatics analysis of microarray data. -tissue_expression_ns hsa-mir-429 "Carcinoma, Pancreatic" 27840954 Identfication of key miRNAs in pancreatitis using bioinformatics analysis of microarray data. -tissue_expression_ns hsa-mir-301a Melanoma 27855389 Expression of MicroRNA-301a and its Functional Roles in Malignant Melanoma. -tissue_expression_ns hsa-mir-21 Peritoneal Dialysis Failure 27867039 Peritoneal dialysis effluent miR-21 and miR-589 levels correlate with longitudinal change in peritoneal transport characteristics. -tissue_expression_ns hsa-mir-589 Peritoneal Dialysis Failure 27867039 Peritoneal dialysis effluent miR-21 and miR-589 levels correlate with longitudinal change in peritoneal transport characteristics. -tissue_expression_ns hsa-mir-199a Autoimmune Diseases [unspecific] 27871116 "Excess glucocorticoids have been shown to modulate the expression of miRNAs, including miR-29a, miR-34a-5p, and miR-199a-5p, which regulate the proliferation and differentiation of osteoblast lineage cells" -tissue_expression_ns hsa-mir-29a Autoimmune Diseases [unspecific] 27871116 "Excess glucocorticoids have been shown to modulate the expression of miRNAs, including miR-29a, miR-34a-5p, and miR-199a-5p, which regulate the proliferation and differentiation of osteoblast lineage cells" -tissue_expression_ns hsa-mir-34a Autoimmune Diseases [unspecific] 27871116 "Excess glucocorticoids have been shown to modulate the expression of miRNAs, including miR-29a, miR-34a-5p, and miR-199a-5p, which regulate the proliferation and differentiation of osteoblast lineage cells" -tissue_expression_ns hsa-mir-122 "Carcinoma, Hepatocellular" 27874954 The anti-cancer effects of cisplatin on hepatic cancer are associated with modulation of miRNA-21 and miRNA-122 expression. -tissue_expression_ns hsa-mir-21 "Carcinoma, Hepatocellular" 27874954 The anti-cancer effects of cisplatin on hepatic cancer are associated with modulation of miRNA-21 and miRNA-122 expression. -tissue_expression_ns hsa-mir-200b "Carcinoma, Lung, Non-Small-Cell" 27876017 miR-27b and miR-200b levels were determined in resected adenocarcinoma and squamous cell carcinoma samples by qRT-PCR -tissue_expression_ns hsa-mir-27b "Carcinoma, Lung, Non-Small-Cell" 27876017 miR-27b and miR-200b levels were determined in resected adenocarcinoma and squamous cell carcinoma samples by qRT-PCR -tissue_expression_ns hsa-mir-122 Liver Cirrhosis 27879410 We also detected expression of hsa-miR-122 in primitive ductular reactions expected for hepatocytic differentiation and hsa-miR-23b cluster expression that drives liver cell fate decisions in cells undergoing lineage commitment -tissue_expression_ns hsa-mir-23b Liver Cirrhosis 27879410 We also detected expression of hsa-miR-122 in primitive ductular reactions expected for hepatocytic differentiation and hsa-miR-23b cluster expression that drives liver cell fate decisions in cells undergoing lineage commitment -tissue_expression_ns hsa-mir-146a Chronic Hepatitis C 27888401 The impact of chronic hepatitis C infection on cholesterol metabolism in PBMCs is associated with microRNA-146a expression. -tissue_expression_ns hsa-mir-186 "Squamous Cell Carcinoma, Esophageal" 27889881 Identification of reference genes and miRNAs for qRT-PCR in human esophageal squamous cell carcinoma. -tissue_expression_ns hsa-mir-28 "Squamous Cell Carcinoma, Esophageal" 27889881 Identification of reference genes and miRNAs for qRT-PCR in human esophageal squamous cell carcinoma. -tissue_expression_ns hsa-mir-34a "Squamous Cell Carcinoma, Esophageal" 27889881 Identification of reference genes and miRNAs for qRT-PCR in human esophageal squamous cell carcinoma. -tissue_expression_ns hsa-let-7b "Carcinoma, Prostate" 27903835 "the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer" -tissue_expression_ns hsa-mir-1179 "Carcinoma, Prostate" 27903835 "the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer" -tissue_expression_ns hsa-mir-1299 "Carcinoma, Prostate" 27903835 "the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer" -tissue_expression_ns hsa-mir-155 "Carcinoma, Prostate" 27903835 "the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer" -tissue_expression_ns hsa-mir-18a "Carcinoma, Prostate" 27903835 "the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer" -tissue_expression_ns hsa-mir-19a "Carcinoma, Prostate" 27903835 "the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer" -tissue_expression_ns hsa-mir-200a "Carcinoma, Prostate" 27903835 "the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer" -tissue_expression_ns hsa-mir-21 "Carcinoma, Prostate" 27903835 "the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer" -tissue_expression_ns hsa-mir-3120 "Carcinoma, Prostate" 27903835 "the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer" -tissue_expression_ns hsa-mir-3149 "Carcinoma, Prostate" 27903835 "the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer" -tissue_expression_ns hsa-mir-3189 "Carcinoma, Prostate" 27903835 "the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer" -tissue_expression_ns hsa-mir-3622b "Carcinoma, Prostate" 27903835 "the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer" -tissue_expression_ns hsa-mir-3677 "Carcinoma, Prostate" 27903835 "the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer" -tissue_expression_ns hsa-mir-3682 "Carcinoma, Prostate" 27903835 "the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer" -tissue_expression_ns hsa-mir-3689d "Carcinoma, Prostate" 27903835 "the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer" -tissue_expression_ns hsa-mir-410 "Carcinoma, Prostate" 27903835 "the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer" -tissue_expression_ns hsa-mir-4469 "Carcinoma, Prostate" 27903835 "the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer" -tissue_expression_ns hsa-mir-4518 "Carcinoma, Prostate" 27903835 "the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer" -tissue_expression_ns hsa-mir-5189 "Carcinoma, Prostate" 27903835 "the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer" -tissue_expression_ns hsa-mir-639 "Carcinoma, Prostate" 27903835 "the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer" -tissue_expression_ns hsa-mir-92b "Carcinoma, Prostate" 27903835 "the outcome of the study has important clinical implications for the management of prostate cancer, including the use of miRNA(s) as biomarkers for early detection of prostate cancer" -tissue_expression_ns hsa-mir-210 "Stroke, Ischemic" 27906445 The expression research of miR-210 in the elderly patients with COPD combined with ischemic stroke. -tissue_expression_ns hsa-mir-130a "Carcinoma, Prostate" 27915273 Altered miRNA expression in high-fat diet-induced prostate cancer progression. -tissue_expression_ns hsa-mir-1276 "Carcinoma, Laryngeal" 27916417 "CCR6 was positively associated with miR-20a-5p, miR-489 and negatively related to miR-29-3p, miR-632 and miR-1276 in laryngeal cancer tissues" -tissue_expression_ns hsa-mir-20a "Carcinoma, Laryngeal" 27916417 "CCR6 was positively associated with miR-20a-5p, miR-489 and negatively related to miR-29-3p, miR-632 and miR-1277 in laryngeal cancer tissues" -tissue_expression_ns hsa-mir-29 "Carcinoma, Laryngeal" 27916417 "CCR6 was positively associated with miR-20a-5p, miR-489 and negatively related to miR-29-3p, miR-632 and miR-1278 in laryngeal cancer tissues" -tissue_expression_ns hsa-mir-489 "Carcinoma, Laryngeal" 27916417 "CCR6 was positively associated with miR-20a-5p, miR-489 and negatively related to miR-29-3p, miR-632 and miR-1279 in laryngeal cancer tissues" -tissue_expression_ns hsa-mir-632 "Carcinoma, Laryngeal" 27916417 "CCR6 was positively associated with miR-20a-5p, miR-489 and negatively related to miR-29-3p, miR-632 and miR-1280 in laryngeal cancer tissues" -tissue_expression_ns hsa-mir-1246 Colorectal Carcinoma 27916938 Comprehensive Analysis of miRNome Alterations in Response to Sorafenib Treatment in Colorectal Cancer Cells. -tissue_expression_ns hsa-mir-1290 Colorectal Carcinoma 27916938 Comprehensive Analysis of miRNome Alterations in Response to Sorafenib Treatment in Colorectal Cancer Cells. -tissue_expression_ns hsa-mir-20a Colorectal Carcinoma 27916938 Comprehensive Analysis of miRNome Alterations in Response to Sorafenib Treatment in Colorectal Cancer Cells. -tissue_expression_ns hsa-mir-3142 Colorectal Carcinoma 27916938 Comprehensive Analysis of miRNome Alterations in Response to Sorafenib Treatment in Colorectal Cancer Cells. -tissue_expression_ns hsa-mir-3182 Colorectal Carcinoma 27916938 Comprehensive Analysis of miRNome Alterations in Response to Sorafenib Treatment in Colorectal Cancer Cells. -tissue_expression_ns hsa-mir-4286 Colorectal Carcinoma 27916938 Comprehensive Analysis of miRNome Alterations in Response to Sorafenib Treatment in Colorectal Cancer Cells. -tissue_expression_ns hsa-mir-4301 Colorectal Carcinoma 27916938 Comprehensive Analysis of miRNome Alterations in Response to Sorafenib Treatment in Colorectal Cancer Cells. -tissue_expression_ns hsa-mir-597 Colorectal Carcinoma 27916938 Comprehensive Analysis of miRNome Alterations in Response to Sorafenib Treatment in Colorectal Cancer Cells. -tissue_expression_ns hsa-mir-720 Colorectal Carcinoma 27916938 Comprehensive Analysis of miRNome Alterations in Response to Sorafenib Treatment in Colorectal Cancer Cells. -tissue_expression_ns hsa-mir-125b "Squamous Cell Carcinoma, Oral" 27935034 Integrated Analysis and MicroRNA Expression Profiling Identified Seven miRNAs Associated With Progression of Oral Squamous Cell Carcinoma. -tissue_expression_ns hsa-mir-133a "Squamous Cell Carcinoma, Oral" 27935034 Integrated Analysis and MicroRNA Expression Profiling Identified Seven miRNAs Associated With Progression of Oral Squamous Cell Carcinoma. -tissue_expression_ns hsa-mir-133b "Squamous Cell Carcinoma, Oral" 27935034 Integrated Analysis and MicroRNA Expression Profiling Identified Seven miRNAs Associated With Progression of Oral Squamous Cell Carcinoma. -tissue_expression_ns hsa-mir-139 "Squamous Cell Carcinoma, Oral" 27935034 Integrated Analysis and MicroRNA Expression Profiling Identified Seven miRNAs Associated With Progression of Oral Squamous Cell Carcinoma. -tissue_expression_ns hsa-mir-21 "Squamous Cell Carcinoma, Oral" 27935034 Integrated Analysis and MicroRNA Expression Profiling Identified Seven miRNAs Associated With Progression of Oral Squamous Cell Carcinoma. -tissue_expression_ns hsa-mir-31 "Squamous Cell Carcinoma, Oral" 27935034 Integrated Analysis and MicroRNA Expression Profiling Identified Seven miRNAs Associated With Progression of Oral Squamous Cell Carcinoma. -tissue_expression_ns hsa-mir-338 "Squamous Cell Carcinoma, Oral" 27935034 Integrated Analysis and MicroRNA Expression Profiling Identified Seven miRNAs Associated With Progression of Oral Squamous Cell Carcinoma. -tissue_expression_ns hsa-mir-1 Aortic Aneurysm 27939432 Regulation of microRNA expression in vascular smooth muscle by MRTF-A and actin polymerization. -tissue_expression_ns hsa-mir-143 Aortic Aneurysm 27939432 Regulation of microRNA expression in vascular smooth muscle by MRTF-A and actin polymerization. -tissue_expression_ns hsa-mir-145 Aortic Aneurysm 27939432 Regulation of microRNA expression in vascular smooth muscle by MRTF-A and actin polymerization. -tissue_expression_ns hsa-mir-22 Aortic Aneurysm 27939432 Regulation of microRNA expression in vascular smooth muscle by MRTF-A and actin polymerization. -tissue_expression_ns hsa-mir-378a Aortic Aneurysm 27939432 Regulation of microRNA expression in vascular smooth muscle by MRTF-A and actin polymerization. -tissue_expression_ns hsa-mir-203 "Squamous Cell Carcinoma, Skin or Unspecific" 27943259 MicroRNA (miR)-203 and miR-205 expression patterns identify subgroups of prognosis in cutaneous squamous cell carcinoma. -tissue_expression_ns hsa-mir-205 "Squamous Cell Carcinoma, Skin or Unspecific" 27943259 MicroRNA (miR)-203 and miR-205 expression patterns identify subgroups of prognosis in cutaneous squamous cell carcinoma. -tissue_expression_ns hsa-mir-15a Salivary Gland Neoplasms 27981346 Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis. -tissue_expression_ns hsa-mir-16 Salivary Gland Neoplasms 27981346 Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis. -tissue_expression_ns hsa-mir-17 Salivary Gland Neoplasms 27981346 Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis. -tissue_expression_ns hsa-mir-20a Salivary Gland Neoplasms 27981346 Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis. -tissue_expression_ns hsa-mir-21 Salivary Gland Neoplasms 27981346 Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis. -tissue_expression_ns hsa-mir-29 Salivary Gland Neoplasms 27981346 Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis. -tissue_expression_ns hsa-mir-34 Salivary Gland Neoplasms 27981346 Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis. -tissue_expression_ns hsa-mir-34a Salivary Gland Neoplasms 27981346 Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis. -tissue_expression_ns hsa-mir-106b "Squamous Cell Carcinoma, Esophageal" 27998862 Expression of mir-106b in esophageal squamous cell carcinoma. -tissue_expression_ns hsa-mir-107 Glioma 27999452 "Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth" -tissue_expression_ns hsa-mir-126 Glioma 27999452 "Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth" -tissue_expression_ns hsa-mir-135 Glioma 27999452 "Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth" -tissue_expression_ns hsa-mir-137 Glioma 27999452 "Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth" -tissue_expression_ns hsa-mir-138 Glioma 27999452 "Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth" -tissue_expression_ns hsa-mir-145 Glioma 27999452 "Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth" -tissue_expression_ns hsa-mir-150 Glioma 27999452 "Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth" -tissue_expression_ns hsa-mir-155 Glioma 27999452 "Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth" -tissue_expression_ns hsa-mir-181a Glioma 27999452 "Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth" -tissue_expression_ns hsa-mir-184 Glioma 27999452 "Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth" -tissue_expression_ns hsa-mir-205 Glioma 27999452 "Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth" -tissue_expression_ns hsa-mir-21 Glioma 27999452 "Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth" -tissue_expression_ns hsa-mir-218 Glioma 27999452 "Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth" -tissue_expression_ns hsa-mir-7 Glioma 27999452 "Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth" -tissue_expression_ns hsa-mir-9 Glioma 27999452 "Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth" -tissue_expression_ns hsa-mir-98 Glioma 27999452 "Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth" -tissue_expression_ns hsa-mir-99b Glioma 27999452 "Deregulation of miRNAs is caused by viral infections, tumorigenesis, and so forth" -tissue_expression_ns hsa-mir-29a Diabetes Mellitus 28003969 Expression and regulation of microRNA-29a and microRNA-29c in early diabetic rat cataract formation. -tissue_expression_ns hsa-mir-29c Diabetes Mellitus 28003969 Expression and regulation of microRNA-29a and microRNA-29c in early diabetic rat cataract formation. -tissue_expression_ns hsa-mir-26a Pituitary Adenoma 28012286 Expression and Clinical Significance of miR-26a and Pleomorphic Adenoma Gene 1 (PLAG1) in Invasive Pituitary Adenoma. -tissue_expression_ns hsa-mir-142 Lymphoma 28031239 "MicroRNAs 142-3p, miR-155 and miR-203 Are Deregulated in Gastric MALT Lymphomas Compared to Chronic Gastritis." -tissue_expression_ns hsa-mir-155 Lymphoma 28031239 "MicroRNAs 142-3p, miR-155 and miR-203 Are Deregulated in Gastric MALT Lymphomas Compared to Chronic Gastritis." -tissue_expression_ns hsa-mir-203 Lymphoma 28031239 "MicroRNAs 142-3p, miR-155 and miR-203 Are Deregulated in Gastric MALT Lymphomas Compared to Chronic Gastritis." -tissue_expression_ns hsa-mir-34b Prostate Neoplasms 28039468 Differential expression of miR-34b and androgen receptor pathway regulate prostate cancer aggressiveness between African-Americans and Caucasians. -tissue_expression_ns hsa-mir-29 Malignant Neoplasms [unspecific] 28063172 Prognostic value of the MicroRNA-29 family in multiple human cancers: A meta-analysis and systematic review. -tissue_expression_ns hsa-mir-140 Osteoarthritis 28065216 Expression of miRNA-140 in Chondrocytes and Synovial Fluid of Knee Joints in Patients with Osteoarthritis. -tissue_expression_ns hsa-mir-155 Porphyromonas Gingivalis 28069815 Identification and Characterization of MicroRNA Differentially Expressed in Macrophages Exposed to Porphyromonas gingivalis Infection. -tissue_expression_ns hsa-mir-1184 "Carcinoma, Prostate" 28072703 Screening the key microRNAs and transcription factors in prostate cancer based on microRNA functional synergistic relationships. -tissue_expression_ns hsa-mir-1207 "Carcinoma, Prostate" 28072703 Screening the key microRNAs and transcription factors in prostate cancer based on microRNA functional synergistic relationships. -tissue_expression_ns hsa-mir-182 "Carcinoma, Prostate" 28072703 Screening the key microRNAs and transcription factors in prostate cancer based on microRNA functional synergistic relationships. -tissue_expression_ns hsa-mir-183 "Carcinoma, Prostate" 28072703 Screening the key microRNAs and transcription factors in prostate cancer based on microRNA functional synergistic relationships. -tissue_expression_ns hsa-mir-24 "Carcinoma, Prostate" 28072703 Screening the key microRNAs and transcription factors in prostate cancer based on microRNA functional synergistic relationships. -tissue_expression_ns hsa-mir-223 Lyme Disease 28076897 MicroRNA Expression Shows Inflammatory Dysregulation and Tumor-Like Proliferative Responses in Joints of Patients With Postinfectious Lyme Arthritis. -tissue_expression_ns hsa-mir-106a Psoriasis 28077577 Extracellular MicroRNA Signature of Human Helper T Cell Subsets in Health and Autoimmunity. -tissue_expression_ns hsa-mir-146a Psoriasis 28077577 Extracellular MicroRNA Signature of Human Helper T Cell Subsets in Health and Autoimmunity. -tissue_expression_ns hsa-mir-150 Psoriasis 28077577 Extracellular MicroRNA Signature of Human Helper T Cell Subsets in Health and Autoimmunity. -tissue_expression_ns hsa-mir-155 Psoriasis 28077577 Extracellular MicroRNA Signature of Human Helper T Cell Subsets in Health and Autoimmunity. -tissue_expression_ns hsa-mir-19a Psoriasis 28077577 Extracellular MicroRNA Signature of Human Helper T Cell Subsets in Health and Autoimmunity. -tissue_expression_ns hsa-mir-21 Psoriasis 28077577 Extracellular MicroRNA Signature of Human Helper T Cell Subsets in Health and Autoimmunity. -tissue_expression_ns hsa-mir-1 Myotonic Muscular Dystrophy 28078570 Micro-RNA expression in muscle and fiber morphometry in myotonic dystrophy type 1. -tissue_expression_ns hsa-mir-133a Myotonic Muscular Dystrophy 28078570 Micro-RNA expression in muscle and fiber morphometry in myotonic dystrophy type 1. -tissue_expression_ns hsa-mir-133b Myotonic Muscular Dystrophy 28078570 Micro-RNA expression in muscle and fiber morphometry in myotonic dystrophy type 1. -tissue_expression_ns hsa-mir-206 Myotonic Muscular Dystrophy 28078570 Micro-RNA expression in muscle and fiber morphometry in myotonic dystrophy type 1. -tissue_expression_ns hsa-mir-126 Vascular Disease [unspecific] 28082910 "Acute Effects of Different Exercise Protocols on the Circulating Vascular microRNAs -16, -21, and -126 in Trained Subjects." -tissue_expression_ns hsa-mir-16 Vascular Disease [unspecific] 28082910 "Acute Effects of Different Exercise Protocols on the Circulating Vascular microRNAs -16, -21, and -126 in Trained Subjects." -tissue_expression_ns hsa-mir-21 Vascular Disease [unspecific] 28082910 "Acute Effects of Different Exercise Protocols on the Circulating Vascular microRNAs -16, -21, and -126 in Trained Subjects." -tissue_expression_ns hsa-mir-140 Osteoarthritis 28085114 Hydrostatic Pressure Regulates MicroRNA Expression Levels in Osteoarthritic Chondrocyte Cultures via the Wnt/¦Â-Catenin Pathway. -tissue_expression_ns hsa-mir-146a Osteoarthritis 28085114 Hydrostatic Pressure Regulates MicroRNA Expression Levels in Osteoarthritic Chondrocyte Cultures via the Wnt/¦Â-Catenin Pathway. -tissue_expression_ns hsa-mir-146b Osteoarthritis 28085114 Hydrostatic Pressure Regulates MicroRNA Expression Levels in Osteoarthritic Chondrocyte Cultures via the Wnt/¦Â-Catenin Pathway. -tissue_expression_ns hsa-mir-27a Osteoarthritis 28085114 Hydrostatic Pressure Regulates MicroRNA Expression Levels in Osteoarthritic Chondrocyte Cultures via the Wnt/¦Â-Catenin Pathway. -tissue_expression_ns hsa-mir-27b Osteoarthritis 28085114 Hydrostatic Pressure Regulates MicroRNA Expression Levels in Osteoarthritic Chondrocyte Cultures via the Wnt/¦Â-Catenin Pathway. -tissue_expression_ns hsa-mir-365 Osteoarthritis 28085114 Hydrostatic Pressure Regulates MicroRNA Expression Levels in Osteoarthritic Chondrocyte Cultures via the Wnt/¦Â-Catenin Pathway. -tissue_expression_ns hsa-mir-2278 "Carcinoma, Renal Cell" 28099931 A new semisynthetic cardenolide analog 3¦Â-2-(1-amantadine)- 1-on-ethylamine-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines. -tissue_expression_ns hsa-mir-670 "Carcinoma, Renal Cell" 28099931 A new semisynthetic cardenolide analog 3¦Â-2-(1-amantadine)- 1-on-ethylamine-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines. -tissue_expression_ns hsa-mir-10b Breast Neoplasms 28101798 "miR-10b, miR-26a, miR-146a And miR-153 Expression in Triple Negative Vs Non Triple Negative Breast Cancer: Potential Biomarkers." -tissue_expression_ns hsa-mir-146a Breast Neoplasms 28101798 "miR-10b, miR-26a, miR-146a And miR-153 Expression in Triple Negative Vs Non Triple Negative Breast Cancer: Potential Biomarkers." -tissue_expression_ns hsa-mir-153 Breast Neoplasms 28101798 "miR-10b, miR-26a, miR-146a And miR-153 Expression in Triple Negative Vs Non Triple Negative Breast Cancer: Potential Biomarkers." -tissue_expression_ns hsa-mir-26a Breast Neoplasms 28101798 "miR-10b, miR-26a, miR-146a And miR-153 Expression in Triple Negative Vs Non Triple Negative Breast Cancer: Potential Biomarkers." -tissue_expression_ns hsa-mir-17 Leukemia 28105201 "Comparison of microRNA expression profiles in K562-cells-derived microvesicles and parental cells, and analysis of their roles in leukemia." -tissue_expression_ns hsa-mir-638 "Squamous Cell Carcinoma, Esophageal" 28108314 MiRNA-638 promotes autophagy and malignant phenotypes of cancer cells via directly suppressing DACT3. -tissue_expression_ns hsa-mir-141 "Adenocarcinoma, Sebaceous" 28119291 miRNA-200c and miRNA-141 as potential prognostic biomarkers and regulators of epithelial-mesenchymal transition in eyelid sebaceous gland carcinoma. -tissue_expression_ns hsa-mir-200c "Adenocarcinoma, Sebaceous" 28119291 miRNA-200c and miRNA-141 as potential prognostic biomarkers and regulators of epithelial-mesenchymal transition in eyelid sebaceous gland carcinoma. -tissue_expression_ns hsa-mir-223 Penis Carcinoma 28122331 Integrative miRNA and mRNA analysis in penile carcinomas reveals markers and pathways with potential clinical impact. -tissue_expression_ns hsa-mir-224 Penis Carcinoma 28122331 Integrative miRNA and mRNA analysis in penile carcinomas reveals markers and pathways with potential clinical impact. -tissue_expression_ns hsa-mir-31 Penis Carcinoma 28122331 Integrative miRNA and mRNA analysis in penile carcinomas reveals markers and pathways with potential clinical impact. -tissue_expression_ns hsa-mir-16 Endometrial Neoplasms 28129244 Aberrant MicroRNA Expression in Patients With Endometrial Cancer. -tissue_expression_ns hsa-mir-106b Chronic Kidney Disease 28148896 "Investigated the safety of intra-renal arterial transfusion of autologous CD34+ cells and time courses of creatinine levels, endothelial dysfunction biomarkers and micro-RNAs in chronic kidney disease patients-phase I clinical trial." -tissue_expression_ns hsa-mir-19a Chronic Kidney Disease 28148896 "Investigated the safety of intra-renal arterial transfusion of autologous CD34+ cells and time courses of creatinine levels, endothelial dysfunction biomarkers and micro-RNAs in chronic kidney disease patients-phase I clinical trial." -tissue_expression_ns hsa-mir-20a Chronic Kidney Disease 28148896 "Investigated the safety of intra-renal arterial transfusion of autologous CD34+ cells and time courses of creatinine levels, endothelial dysfunction biomarkers and micro-RNAs in chronic kidney disease patients-phase I clinical trial." -tissue_expression_ns hsa-mir-26b Chronic Kidney Disease 28148896 "Investigated the safety of intra-renal arterial transfusion of autologous CD34+ cells and time courses of creatinine levels, endothelial dysfunction biomarkers and micro-RNAs in chronic kidney disease patients-phase I clinical trial." -tissue_expression_ns hsa-mir-374a Chronic Kidney Disease 28148896 "Investigated the safety of intra-renal arterial transfusion of autologous CD34+ cells and time courses of creatinine levels, endothelial dysfunction biomarkers and micro-RNAs in chronic kidney disease patients-phase I clinical trial." -tissue_expression_ns hsa-mir-122 "Carcinoma, Renal Cell, Clear-Cell" 28184927 "miR-122 and miR-34a, respectively, may regulate their expression in this cancer" -tissue_expression_ns hsa-mir-34a "Carcinoma, Renal Cell, Clear-Cell" 28184927 Downregulation of OCLN and GAS1 in clear cell renal cell carcinoma. -tissue_expression_ns hsa-mir-21 Pancreatic Neoplasms 28186267 "We also examined miRNA expression [microRNA-21 (miR-21) and microRNA-31 (miR-31)] and epigenetic alterations, including CpG island methylator phenotype (CIMP), potentially associated with the identified miRNAs" -tissue_expression_ns hsa-mir-31 Pancreatic Neoplasms 28186267 "We also examined miRNA expression [microRNA-21 (miR-21) and microRNA-31 (miR-31)] and epigenetic alterations, including CpG island methylator phenotype (CIMP), potentially associated with the identified miRNAs" -tissue_expression_ns hsa-mir-155 Asthma 28199728 Altered miR-155 Expression in Allergic Asthmatic Airways. -tissue_expression_ns hsa-mir-21 Colorectal Carcinoma 28207045 Remodelling of microRNAs in colorectal cancer by hypoxia alters metabolism profiles and 5-fluorouracil resistance. -tissue_expression_ns hsa-mir-210 Colorectal Carcinoma 28207045 Remodelling of microRNAs in colorectal cancer by hypoxia alters metabolism profiles and 5-fluorouracil resistance. -tissue_expression_ns hsa-mir-30d Colorectal Carcinoma 28207045 Remodelling of microRNAs in colorectal cancer by hypoxia alters metabolism profiles and 5-fluorouracil resistance. -tissue_expression_ns hsa-mir-19a Osteosarcoma 28214202 Elevated expression of microRNA-19a predicts a poor prognosis in patients with osteosarcoma. -tissue_expression_ns hsa-let-7a Cutaneous Melanoma 28218741 Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing. -tissue_expression_ns hsa-let-7b Cutaneous Melanoma 28218741 Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing. -tissue_expression_ns hsa-mir-182 Cutaneous Melanoma 28218741 Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing. -tissue_expression_ns hsa-mir-199b Cutaneous Melanoma 28218741 Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing. -tissue_expression_ns hsa-mir-205 Cutaneous Melanoma 28218741 Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing. -tissue_expression_ns hsa-mir-21 Cutaneous Melanoma 28218741 Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing. -tissue_expression_ns hsa-mir-423 Cutaneous Melanoma 28218741 Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing. -tissue_expression_ns hsa-mir-424 Cutaneous Melanoma 28218741 Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing. -tissue_expression_ns hsa-mir-26a "Carcinoma, Hepatocellular" 28218742 "MiRNA expression profiles reveal the involvement of miR-26a, miR-548l and miR-34a in hepatocellular carcinoma progression through regulation of ST3GAL5." -tissue_expression_ns hsa-mir-34a "Carcinoma, Hepatocellular" 28218742 "MiRNA expression profiles reveal the involvement of miR-26a, miR-548l and miR-34a in hepatocellular carcinoma progression through regulation of ST3GAL5." -tissue_expression_ns hsa-mir-548l "Carcinoma, Hepatocellular" 28218742 "MiRNA expression profiles reveal the involvement of miR-26a, miR-548l and miR-34a in hepatocellular carcinoma progression through regulation of ST3GAL5." -tissue_expression_ns hsa-mir-17 Neoplasms [unspecific] 28222938 The role of miR-17-92 cluster in the expression of tumor suppressor genes in unrestricted somatic stem cells. -tissue_expression_ns hsa-mir-18a Neoplasms [unspecific] 28222938 The role of miR-17-92 cluster in the expression of tumor suppressor genes in unrestricted somatic stem cells. -tissue_expression_ns hsa-mir-19a Neoplasms [unspecific] 28222938 The role of miR-17-92 cluster in the expression of tumor suppressor genes in unrestricted somatic stem cells. -tissue_expression_ns hsa-mir-19b Neoplasms [unspecific] 28222938 The role of miR-17-92 cluster in the expression of tumor suppressor genes in unrestricted somatic stem cells. -tissue_expression_ns hsa-mir-20a Neoplasms [unspecific] 28222938 The role of miR-17-92 cluster in the expression of tumor suppressor genes in unrestricted somatic stem cells. -tissue_expression_ns hsa-mir-92a Neoplasms [unspecific] 28222938 The role of miR-17-92 cluster in the expression of tumor suppressor genes in unrestricted somatic stem cells. -tissue_expression_ns hsa-mir-155 Atherosclerosis 28234622 "CagA-positive and CagA-negative Helicobacter pylori strains differentially affect the expression of micro RNAs 21, 92a, 155 and 663 in human umbilical vein endothelial cells." -tissue_expression_ns hsa-mir-21 Atherosclerosis 28234622 "CagA-positive and CagA-negative Helicobacter pylori strains differentially affect the expression of micro RNAs 21, 92a, 155 and 663 in human umbilical vein endothelial cells." -tissue_expression_ns hsa-mir-663 Atherosclerosis 28234622 "CagA-positive and CagA-negative Helicobacter pylori strains differentially affect the expression of micro RNAs 21, 92a, 155 and 663 in human umbilical vein endothelial cells." -tissue_expression_ns hsa-mir-92a Atherosclerosis 28234622 "CagA-positive and CagA-negative Helicobacter pylori strains differentially affect the expression of micro RNAs 21, 92a, 155 and 663 in human umbilical vein endothelial cells." -tissue_expression_ns hsa-mir-127 Prostate Neoplasms 28239051 MicroRNA expression profiling in canine prostate cancer. -tissue_expression_ns hsa-mir-203 Endomyocardial Fibrosis 28272698 Effect of miR-203 expression on myocardial fibrosis. -tissue_expression_ns hsa-mir-122 "Carcinoma, Hepatocellular" 28272709 Expression of microRNA-122 and microRNA-22 in HBV-related liver cancer and the correlation with clinical features. -tissue_expression_ns hsa-mir-22 "Carcinoma, Hepatocellular" 28272709 Expression of microRNA-122 and microRNA-22 in HBV-related liver cancer and the correlation with clinical features. -tissue_expression_ns hsa-mir-106b Osteosarcoma 28272712 The expression and function of miRNA-106 in pediatric osteosarcoma. -tissue_expression_ns hsa-mir-542 "Squamous Cell Carcinoma, Oral" 28275798 Expression and correlation of survivin and hsa-miR-542-3p in patients with oral squamous cell carcinoma. -tissue_expression_ns hsa-mir-10b Colorectal Carcinoma 28289479 Colorectal adenoma and carcinoma specific miRNA profiles in biopsy and their expression in plasma specimens. -tissue_expression_ns hsa-mir-183 Colorectal Carcinoma 28289479 Colorectal adenoma and carcinoma specific miRNA profiles in biopsy and their expression in plasma specimens. -tissue_expression_ns hsa-let-7a Pituitary Neoplasms 28300776 Evolution of Fish Let-7 MicroRNAs and Their Expression Correlated to Growth Development in Blunt Snout Bream. -tissue_expression_ns hsa-let-7b Pituitary Neoplasms 28300776 Evolution of Fish Let-7 MicroRNAs and Their Expression Correlated to Growth Development in Blunt Snout Bream. -tissue_expression_ns hsa-let-7c Pituitary Neoplasms 28300776 Evolution of Fish Let-7 MicroRNAs and Their Expression Correlated to Growth Development in Blunt Snout Bream. -tissue_expression_ns hsa-let-7d Pituitary Neoplasms 28300776 Evolution of Fish Let-7 MicroRNAs and Their Expression Correlated to Growth Development in Blunt Snout Bream. -tissue_expression_ns hsa-let-7e Pituitary Neoplasms 28300776 Evolution of Fish Let-7 MicroRNAs and Their Expression Correlated to Growth Development in Blunt Snout Bream. -tissue_expression_ns hsa-let-7f Pituitary Neoplasms 28300776 Evolution of Fish Let-7 MicroRNAs and Their Expression Correlated to Growth Development in Blunt Snout Bream. -tissue_expression_ns hsa-let-7g Pituitary Neoplasms 28300776 Evolution of Fish Let-7 MicroRNAs and Their Expression Correlated to Growth Development in Blunt Snout Bream. -tissue_expression_ns hsa-let-7i Pituitary Neoplasms 28300776 Evolution of Fish Let-7 MicroRNAs and Their Expression Correlated to Growth Development in Blunt Snout Bream. -tissue_expression_ns hsa-mir-150 Human Papilloma Virus Infection 28302562 Dysregulated expression of microRNA-150 in human papillomavirus-induced lesions of K14-HPV16 transgenic mice. -tissue_expression_ns hsa-mir-181a Pituitary Adenoma 28315020 Novel Biomarkers for Non-functioning Invasive Pituitary Adenomas were Identified by Using Analysis of microRNAs Expression Profile. -tissue_expression_ns hsa-mir-181b Pituitary Adenoma 28315020 Novel Biomarkers for Non-functioning Invasive Pituitary Adenomas were Identified by Using Analysis of microRNAs Expression Profile. -tissue_expression_ns hsa-mir-181d Pituitary Adenoma 28315020 Novel Biomarkers for Non-functioning Invasive Pituitary Adenomas were Identified by Using Analysis of microRNAs Expression Profile. -tissue_expression_ns hsa-mir-191 Pituitary Adenoma 28315020 Novel Biomarkers for Non-functioning Invasive Pituitary Adenomas were Identified by Using Analysis of microRNAs Expression Profile. -tissue_expression_ns hsa-mir-3676 Pituitary Adenoma 28315020 Novel Biomarkers for Non-functioning Invasive Pituitary Adenomas were Identified by Using Analysis of microRNAs Expression Profile. -tissue_expression_ns hsa-mir-383 Pituitary Adenoma 28315020 Novel Biomarkers for Non-functioning Invasive Pituitary Adenomas were Identified by Using Analysis of microRNAs Expression Profile. -tissue_expression_ns hsa-mir-598 Pituitary Adenoma 28315020 Novel Biomarkers for Non-functioning Invasive Pituitary Adenomas were Identified by Using Analysis of microRNAs Expression Profile. -tissue_expression_ns hsa-mir-146a Sjogren Syndrome 28339495 MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sj?gren's syndrome. -tissue_expression_ns hsa-mir-146a Systemic Lupus Erythematosus 28339495 MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sj?gren's syndrome. -tissue_expression_ns hsa-mir-148a Sjogren Syndrome 28339495 MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sj?gren's syndrome. -tissue_expression_ns hsa-mir-148a Systemic Lupus Erythematosus 28339495 MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sj?gren's syndrome. -tissue_expression_ns hsa-mir-150 Sjogren Syndrome 28339495 MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sj?gren's syndrome. -tissue_expression_ns hsa-mir-150 Systemic Lupus Erythematosus 28339495 MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sj?gren's syndrome. -tissue_expression_ns hsa-mir-152 Sjogren Syndrome 28339495 MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sj?gren's syndrome. -tissue_expression_ns hsa-mir-152 Systemic Lupus Erythematosus 28339495 MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sj?gren's syndrome. -tissue_expression_ns hsa-mir-155 Sjogren Syndrome 28339495 MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sj?gren's syndrome. -tissue_expression_ns hsa-mir-155 Systemic Lupus Erythematosus 28339495 MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sj?gren's syndrome. -tissue_expression_ns hsa-mir-16 Sjogren Syndrome 28339495 MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sj?gren's syndrome. -tissue_expression_ns hsa-mir-16 Systemic Lupus Erythematosus 28339495 MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sj?gren's syndrome. -tissue_expression_ns hsa-mir-21 Sjogren Syndrome 28339495 MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sj?gren's syndrome. -tissue_expression_ns hsa-mir-21 Systemic Lupus Erythematosus 28339495 MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sj?gren's syndrome. -tissue_expression_ns hsa-mir-223 Sjogren Syndrome 28339495 MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sj?gren's syndrome. -tissue_expression_ns hsa-mir-223 Systemic Lupus Erythematosus 28339495 MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sj?gren's syndrome. -tissue_expression_ns hsa-mir-224 Sjogren Syndrome 28339495 MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sj?gren's syndrome. -tissue_expression_ns hsa-mir-224 Systemic Lupus Erythematosus 28339495 MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sj?gren's syndrome. -tissue_expression_ns hsa-mir-326 Sjogren Syndrome 28339495 MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sj?gren's syndrome. -tissue_expression_ns hsa-mir-326 Systemic Lupus Erythematosus 28339495 MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sj?gren's syndrome. -tissue_expression_ns hsa-mir-342 Sjogren Syndrome 28339495 MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sj?gren's syndrome. -tissue_expression_ns hsa-mir-342 Systemic Lupus Erythematosus 28339495 MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sj?gren's syndrome. -tissue_expression_ns hsa-mir-149 "Adenocarcinoma, Lung" 28345454 Genome-wide profiling of micro-RNA expression in gefitinib-resistant human lung adenocarcinoma using microarray for the identification of miR-149-5p modulation. -tissue_expression_ns hsa-mir-155 "Squamous Cell Carcinoma, Head and Neck" 28347920 MiR-200b and miR-155 as predictive biomarkers for the efficacy of chemoradiation in locally advanced head and neck squamous cell carcinoma. -tissue_expression_ns hsa-mir-200b "Squamous Cell Carcinoma, Head and Neck" 28347920 MiR-200b and miR-155 as predictive biomarkers for the efficacy of chemoradiation in locally advanced head and neck squamous cell carcinoma. -tissue_expression_ns hsa-mir-107 Meningioma 28349893 "Expression of miRNA-21, miRNA-107, miRNA-137 and miRNA-29b in meningioma." -tissue_expression_ns hsa-mir-137 Meningioma 28349893 "Expression of miRNA-21, miRNA-107, miRNA-137 and miRNA-29b in meningioma." -tissue_expression_ns hsa-mir-21 Meningioma 28349893 "Expression of miRNA-21, miRNA-107, miRNA-137 and miRNA-29b in meningioma." -tissue_expression_ns hsa-mir-29b Meningioma 28349893 "Expression of miRNA-21, miRNA-107, miRNA-137 and miRNA-29b in meningioma." -tissue_expression_ns hsa-let-7a Salivary Gland Neoplasms 28377929 "Expression, Mutation, and Amplification Status of EGFR and Its Correlation with Five miRNAs in Salivary Gland Tumours." -tissue_expression_ns hsa-mir-133b Salivary Gland Neoplasms 28377929 "Expression, Mutation, and Amplification Status of EGFR and Its Correlation with Five miRNAs in Salivary Gland Tumours." -tissue_expression_ns hsa-mir-140 Salivary Gland Neoplasms 28377929 "Expression, Mutation, and Amplification Status of EGFR and Its Correlation with Five miRNAs in Salivary Gland Tumours." -tissue_expression_ns hsa-mir-99b Salivary Gland Neoplasms 28377929 "Expression, Mutation, and Amplification Status of EGFR and Its Correlation with Five miRNAs in Salivary Gland Tumours." -tissue_expression_ns hsa-mir-516 Gestational Trophoblastic Disease 28381180 "Follow-up of gestational trophoblastic disease/neoplasia via quantification of circulating nucleic acids of placental origin using C19MC microRNAs, hypermethylated RASSF1A, and SRY sequences." -tissue_expression_ns hsa-mir-517 Gestational Trophoblastic Disease 28381180 "Follow-up of gestational trophoblastic disease/neoplasia via quantification of circulating nucleic acids of placental origin using C19MC microRNAs, hypermethylated RASSF1A, and SRY sequences." -tissue_expression_ns hsa-mir-518b Gestational Trophoblastic Disease 28381180 "Follow-up of gestational trophoblastic disease/neoplasia via quantification of circulating nucleic acids of placental origin using C19MC microRNAs, hypermethylated RASSF1A, and SRY sequences." -tissue_expression_ns hsa-mir-520a Gestational Trophoblastic Disease 28381180 "Follow-up of gestational trophoblastic disease/neoplasia via quantification of circulating nucleic acids of placental origin using C19MC microRNAs, hypermethylated RASSF1A, and SRY sequences." -tissue_expression_ns hsa-mir-520h Gestational Trophoblastic Disease 28381180 "Follow-up of gestational trophoblastic disease/neoplasia via quantification of circulating nucleic acids of placental origin using C19MC microRNAs, hypermethylated RASSF1A, and SRY sequences." -tissue_expression_ns hsa-mir-525 Gestational Trophoblastic Disease 28381180 "Follow-up of gestational trophoblastic disease/neoplasia via quantification of circulating nucleic acids of placental origin using C19MC microRNAs, hypermethylated RASSF1A, and SRY sequences." -tissue_expression_ns hsa-mir-526a Gestational Trophoblastic Disease 28381180 "Follow-up of gestational trophoblastic disease/neoplasia via quantification of circulating nucleic acids of placental origin using C19MC microRNAs, hypermethylated RASSF1A, and SRY sequences." -tissue_expression_ns hsa-mir-370 Obesity 28386478 Changes in the MicroRNA Profile Observed in the Subcutaneous Adipose Tissue of Obese Patients after Laparoscopic Adjustable Gastric Banding. -tissue_expression_ns hsa-mir-1179 "Carcinoma, Thyroid, Papillary" 28393181 different miRNA expression profiles are associated with different histological types of PTC and different risks of recurrence -tissue_expression_ns hsa-mir-140 "Carcinoma, Thyroid, Papillary" 28393181 different miRNA expression profiles are associated with different histological types of PTC and different risks of recurrence -tissue_expression_ns hsa-mir-144 "Carcinoma, Thyroid, Papillary" 28393181 different miRNA expression profiles are associated with different histological types of PTC and different risks of recurrence -tissue_expression_ns hsa-mir-146b "Carcinoma, Thyroid, Papillary" 28393181 different miRNA expression profiles are associated with different histological types of PTC and different risks of recurrence -tissue_expression_ns hsa-mir-204 "Carcinoma, Thyroid, Papillary" 28393181 different miRNA expression profiles are associated with different histological types of PTC and different risks of recurrence -tissue_expression_ns hsa-mir-21 "Carcinoma, Thyroid, Papillary" 28393181 different miRNA expression profiles are associated with different histological types of PTC and different risks of recurrence -tissue_expression_ns hsa-mir-221 "Carcinoma, Thyroid, Papillary" 28393181 different miRNA expression profiles are associated with different histological types of PTC and different risks of recurrence -tissue_expression_ns hsa-mir-222 "Carcinoma, Thyroid, Papillary" 28393181 different miRNA expression profiles are associated with different histological types of PTC and different risks of recurrence -tissue_expression_ns hsa-mir-486 "Carcinoma, Thyroid, Papillary" 28393181 different miRNA expression profiles are associated with different histological types of PTC and different risks of recurrence -tissue_expression_ns hsa-mir-7 "Carcinoma, Thyroid, Papillary" 28393181 different miRNA expression profiles are associated with different histological types of PTC and different risks of recurrence -tissue_expression_ns hsa-mir-200b Gastrointestinal Neoplasms 28402940 Prognostic role of microRNAs in human gastrointestinal cancer: A systematic review and meta-analysis. -tissue_expression_ns hsa-mir-200c Gastrointestinal Neoplasms 28402940 Prognostic role of microRNAs in human gastrointestinal cancer: A systematic review and meta-analysis. -tissue_expression_ns hsa-mir-203 "Carcinoma, Rectal" 28403349 "Analysis of gene expression EGFR and KRAS, microRNA-21 and microRNA-203 in patients with colon and rectal cancer and correlation with clinical outcome and prognostic factors." -tissue_expression_ns hsa-mir-21 "Carcinoma, Rectal" 28403349 "Analysis of gene expression EGFR and KRAS, microRNA-21 and microRNA-203 in patients with colon and rectal cancer and correlation with clinical outcome and prognostic factors." -tissue_expression_ns hsa-mir-10a Atherosclerosis 28403739 "Hydrogen Peroxide and Lipopolysaccharide Differentially Affect the Expression of MicroRNAs 10a, 33a, 21, 221 in Endothelial Cells Before and After Coculture With Monocytes." -tissue_expression_ns hsa-mir-21 Atherosclerosis 28403739 "Hydrogen Peroxide and Lipopolysaccharide Differentially Affect the Expression of MicroRNAs 10a, 33a, 21, 221 in Endothelial Cells Before and After Coculture With Monocytes." -tissue_expression_ns hsa-mir-221 Atherosclerosis 28403739 "Hydrogen Peroxide and Lipopolysaccharide Differentially Affect the Expression of MicroRNAs 10a, 33a, 21, 221 in Endothelial Cells Before and After Coculture With Monocytes." -tissue_expression_ns hsa-mir-33a Atherosclerosis 28403739 "Hydrogen Peroxide and Lipopolysaccharide Differentially Affect the Expression of MicroRNAs 10a, 33a, 21, 221 in Endothelial Cells Before and After Coculture With Monocytes." -tissue_expression_ns hsa-mir-150 Burns 28404517 Dysregulation of microRNA biogenesis in the small intestine after ethanol and burn injury. -tissue_expression_ns hsa-let-7d Kidney Diseases [unspecific] 28414804 Cyclosporine A alters expression of renal microRNAs: New insights into calcineurin inhibitor nephrotoxicity. -tissue_expression_ns hsa-mir-130 Kidney Diseases [unspecific] 28414804 Cyclosporine A alters expression of renal microRNAs: New insights into calcineurin inhibitor nephrotoxicity. -tissue_expression_ns hsa-mir-186 Kidney Diseases [unspecific] 28414804 Cyclosporine A alters expression of renal microRNAs: New insights into calcineurin inhibitor nephrotoxicity. -tissue_expression_ns hsa-mir-192 Kidney Diseases [unspecific] 28414804 Cyclosporine A alters expression of renal microRNAs: New insights into calcineurin inhibitor nephrotoxicity. -tissue_expression_ns hsa-mir-200 Kidney Diseases [unspecific] 28414804 Cyclosporine A alters expression of renal microRNAs: New insights into calcineurin inhibitor nephrotoxicity. -tissue_expression_ns hsa-mir-21 Kidney Diseases [unspecific] 28414804 Cyclosporine A alters expression of renal microRNAs: New insights into calcineurin inhibitor nephrotoxicity. -tissue_expression_ns hsa-mir-29 Kidney Diseases [unspecific] 28414804 Cyclosporine A alters expression of renal microRNAs: New insights into calcineurin inhibitor nephrotoxicity. -tissue_expression_ns hsa-mir-30 Kidney Diseases [unspecific] 28414804 Cyclosporine A alters expression of renal microRNAs: New insights into calcineurin inhibitor nephrotoxicity. -tissue_expression_ns hsa-mir-709 Kidney Diseases [unspecific] 28414804 Cyclosporine A alters expression of renal microRNAs: New insights into calcineurin inhibitor nephrotoxicity. -tissue_expression_ns hsa-let-7a Ovarian Neoplasms 28423547 Genomic imbalances are involved in miR-30c and let-7a deregulation in ovarian tumors: implications for HMGA2 expression. -tissue_expression_ns hsa-mir-30c Ovarian Neoplasms 28423547 Genomic imbalances are involved in miR-30c and let-7a deregulation in ovarian tumors: implications for HMGA2 expression. -tissue_expression_ns hsa-mir-20a Toxoplasma gondii Infection 28424428 Global miRNA expression profiling of domestic cat livers following acute Toxoplasma gondii infection. -tissue_expression_ns hsa-mir-132 "Carcinoma, Hepatocellular" 28430373 A five-miRNA expression signature predicts survival in hepatocellular carcinoma. -tissue_expression_ns hsa-mir-1468 "Carcinoma, Hepatocellular" 28430373 A five-miRNA expression signature predicts survival in hepatocellular carcinoma. -tissue_expression_ns hsa-mir-212 "Carcinoma, Hepatocellular" 28430373 A five-miRNA expression signature predicts survival in hepatocellular carcinoma. -tissue_expression_ns hsa-mir-301a "Carcinoma, Hepatocellular" 28430373 A five-miRNA expression signature predicts survival in hepatocellular carcinoma. -tissue_expression_ns hsa-mir-489 "Carcinoma, Hepatocellular" 28430373 A five-miRNA expression signature predicts survival in hepatocellular carcinoma. -tissue_expression_ns hsa-let-7a "Carcinoma, Hepatocellular" 28440732 Expression of microRNA let-7a positively correlates with hepatitis B virus replication in hepatocellular carcinoma tissues. -tissue_expression_ns hsa-mir-150 Myeloma 28458781 MicroRNA expression patterns and target prediction in multiple myeloma development and malignancy. -tissue_expression_ns hsa-mir-21 Infection [unspecific] 28472924 Identification of differentially expressed Atlantic salmon miRNAs responding to salmonid alphavirus (SAV) infection. -tissue_expression_ns hsa-mir-452 "Adenocarcinoma, Lung" 28488527 Clinical value of miR-452-5p expression in lung adenocarcinoma: A retrospective quantitative real-time polymerase chain reaction study and verification based on The Cancer Genome Atlas and Gene Expression Omnibus databases. -tissue_expression_ns hsa-mir-10a "Squamous Cell Carcinoma, Head and Neck" 28495058 miRNA profiling of primary lung and head and neck squamous cell carcinomas: Addressing a diagnostic dilemma. -tissue_expression_ns hsa-mir-10b "Squamous Cell Carcinoma, Head and Neck" 28495058 miRNA profiling of primary lung and head and neck squamous cell carcinomas: Addressing a diagnostic dilemma. -tissue_expression_ns hsa-mir-34a "Squamous Cell Carcinoma, Head and Neck" 28495058 miRNA profiling of primary lung and head and neck squamous cell carcinomas: Addressing a diagnostic dilemma. -tissue_expression_ns hsa-mir-140 Thymoma 28517980 "Among the seven significant miRNAs, six (mir-140, mir-450b, mir-542, mir-639, mir-3613 and mir-3913¨C1) were positively associated with OS, while the remaining one (mir-1976) was negatively correlated" -tissue_expression_ns hsa-mir-1976 Thymoma 28517980 "Among the seven significant miRNAs, six (mir-140, mir-450b, mir-542, mir-639, mir-3613 and mir-3913¨C1) were positively associated with OS, while the remaining one (mir-1976) was negatively correlated" -tissue_expression_ns hsa-mir-3613 Thymoma 28517980 "Among the seven significant miRNAs, six (mir-140, mir-450b, mir-542, mir-639, mir-3613 and mir-3913¨C1) were positively associated with OS, while the remaining one (mir-1976) was negatively correlated" -tissue_expression_ns hsa-mir-3913 Thymoma 28517980 "Among the seven significant miRNAs, six (mir-140, mir-450b, mir-542, mir-639, mir-3613 and mir-3913¨C1) were positively associated with OS, while the remaining one (mir-1976) was negatively correlated" -tissue_expression_ns hsa-mir-450b Thymoma 28517980 "Among the seven significant miRNAs, six (mir-140, mir-450b, mir-542, mir-639, mir-3613 and mir-3913¨C1) were positively associated with OS, while the remaining one (mir-1976) was negatively correlated" -tissue_expression_ns hsa-mir-542 Thymoma 28517980 "Among the seven significant miRNAs, six (mir-140, mir-450b, mir-542, mir-639, mir-3613 and mir-3913¨C1) were positively associated with OS, while the remaining one (mir-1976) was negatively correlated" -tissue_expression_ns hsa-mir-639 Thymoma 28517980 "Among the seven significant miRNAs, six (mir-140, mir-450b, mir-542, mir-639, mir-3613 and mir-3913¨C1) were positively associated with OS, while the remaining one (mir-1976) was negatively correlated" -tissue_expression_ns hsa-let-7b "Carcinoma, Lung, Non-Small-Cell" 28534369 "The relationship between miR-17-5p, miR-92a, and let-7b expression with non-small cell lung cancer targeted drug resistance." -tissue_expression_ns hsa-mir-17 "Carcinoma, Lung, Non-Small-Cell" 28534369 "The relationship between miR-17-5p, miR-92a, and let-7b expression with non-small cell lung cancer targeted drug resistance." -tissue_expression_ns hsa-mir-92a "Carcinoma, Lung, Non-Small-Cell" 28534369 "The relationship between miR-17-5p, miR-92a, and let-7b expression with non-small cell lung cancer targeted drug resistance." -tissue_expression_ns hsa-mir-126 Neoplasms [unspecific] 28536479 Circulating microRNA-214 and -126 as potential biomarkers for canine neoplastic disease. -tissue_expression_ns hsa-mir-214 Neoplasms [unspecific] 28536479 Circulating microRNA-214 and -126 as potential biomarkers for canine neoplastic disease. -tissue_expression_ns hsa-mir-15a "Carcinoma, Lung, Non-Small-Cell" 28537679 MiR-15a expression analysis in non-small cell lung cancer A549 cells under local hypoxia microenvironment. -tissue_expression_ns hsa-mir-217 "Adenocarcinoma, Pancreatic Ductal" 28539816 hsa-miR-96 and hsa-miR-217 Expression Down-Regulates with Increasing Dysplasia in Pancreatic Intraepithelial Neoplasias and Intraductal Papillary Mucinous Neoplasms. -tissue_expression_ns hsa-mir-96 "Adenocarcinoma, Pancreatic Ductal" 28539816 hsa-miR-96 and hsa-miR-217 Expression Down-Regulates with Increasing Dysplasia in Pancreatic Intraepithelial Neoplasias and Intraductal Papillary Mucinous Neoplasms. -tissue_expression_ns hsa-mir-29b Parkinson Disease 28540642 Plasma and White Blood Cells Show Different miRNA Expression Profiles in Parkinson's Disease. -tissue_expression_ns hsa-mir-30a Parkinson Disease 28540642 Plasma and White Blood Cells Show Different miRNA Expression Profiles in Parkinson's Disease. -tissue_expression_ns hsa-mir-21 Glioma 28547591 MicroRNA-21 expression in the prognosis of low-grade gliomas: data from the cancer genome atlas (TCGA) project. -tissue_expression_ns hsa-mir-200b Pancreatic Neoplasms 28548126 MicroRNA dysregulation in the tumor microenvironment influences the phenotype of pancreatic cancer. -tissue_expression_ns hsa-mir-200c Pancreatic Neoplasms 28548126 MicroRNA dysregulation in the tumor microenvironment influences the phenotype of pancreatic cancer. -tissue_expression_ns hsa-mir-21 Pancreatic Neoplasms 28548126 MicroRNA dysregulation in the tumor microenvironment influences the phenotype of pancreatic cancer. -tissue_expression_ns hsa-mir-210 Pancreatic Neoplasms 28548126 MicroRNA dysregulation in the tumor microenvironment influences the phenotype of pancreatic cancer. -tissue_expression_ns hsa-mir-106a "Carcinoma, Colon" 28571588 Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line. -tissue_expression_ns hsa-mir-200c "Carcinoma, Colon" 28571588 Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line. -tissue_expression_ns hsa-mir-205 "Carcinoma, Colon" 28571588 Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line. -tissue_expression_ns hsa-mir-302d "Carcinoma, Colon" 28571588 Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line. -tissue_expression_ns hsa-mir-373 "Carcinoma, Colon" 28571588 Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line. -tissue_expression_ns hsa-mir-4454 "Carcinoma, Colon" 28571588 Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line. -tissue_expression_ns hsa-mir-483 "Carcinoma, Colon" 28571588 Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line. -tissue_expression_ns hsa-mir-512 "Carcinoma, Colon" 28571588 Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line. -tissue_expression_ns hsa-mir-93 "Carcinoma, Colon" 28571588 Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line. -tissue_expression_ns hsa-mir-99b "Carcinoma, Colon" 28571588 Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line. -tissue_expression_ns hsa-mir-1178 "Carcinoma, Pancreatic" 28592083 Correlation between miR-1178 expression and clinicopathological significance in human pancreatic cancer. -tissue_expression_ns hsa-mir-146b "Carcinoma, Thyroid, Papillary" 28599426 Dynamic monitoring of circulating microRNAs as a predictive biomarker for the diagnosis and recurrence of papillary thyroid carcinoma. -tissue_expression_ns hsa-mir-221 "Carcinoma, Thyroid, Papillary" 28599426 Dynamic monitoring of circulating microRNAs as a predictive biomarker for the diagnosis and recurrence of papillary thyroid carcinoma. -tissue_expression_ns hsa-mir-183 "Carcinoma, Tounge" 28616749 miR-183 and miR-21 expression as biomarkers of progression and survival in tongue carcinoma patients. -tissue_expression_ns hsa-mir-21 "Carcinoma, Tounge" 28616749 miR-183 and miR-21 expression as biomarkers of progression and survival in tongue carcinoma patients. -tissue_expression_ns hsa-mir-145 "Carcinoma, Prostate" 28617988 MiR-145 detection in urinary extracellular vesicles increase diagnostic efficiency of prostate cancer based on hydrostatic filtration dialysis method. -tissue_expression_ns hsa-mir-7 "Adenocarcinoma, Lung" 28618418 Prognostic Significance of microRNA-7 and its Roles in the Regulation of Cisplatin Resistance in Lung Adenocarcinoma. -tissue_expression_ns hsa-mir-375 Colorectal Carcinoma 28618945 "The expression profiling of serum miR-92a, miR-375, and miR-760 in colorectal cancer: An Egyptian study." -tissue_expression_ns hsa-mir-760 Colorectal Carcinoma 28618945 "The expression profiling of serum miR-92a, miR-375, and miR-760 in colorectal cancer: An Egyptian study." -tissue_expression_ns hsa-mir-92a Colorectal Carcinoma 28618945 "The expression profiling of serum miR-92a, miR-375, and miR-760 in colorectal cancer: An Egyptian study." -tissue_expression_ns hsa-mir-127 Prostate Neoplasms 28621736 A Panel of MicroRNAs as Diagnostic Biomarkers for the Identification of Prostate Cancer. -tissue_expression_ns hsa-mir-21 Gastric Neoplasms 28628924 Chrysin Alters microRNAs Expression Levels in Gastric Cancer Cells: Possible Molecular Mechanism. -tissue_expression_ns hsa-mir-221 Gastric Neoplasms 28628924 Chrysin Alters microRNAs Expression Levels in Gastric Cancer Cells: Possible Molecular Mechanism. -tissue_expression_ns hsa-mir-34a Gastric Neoplasms 28628924 Chrysin Alters microRNAs Expression Levels in Gastric Cancer Cells: Possible Molecular Mechanism. -tissue_expression_ns hsa-let-7a "Carcinoma, Thyroid" 28655518 Effects of long non-coding RNA H19 and microRNA let7a expression on thyroid cancer prognosis. -tissue_expression_ns hsa-mir-133b Glioma 28675056 MicroRNA-133b expression associates with clinicopathological features and prognosis in glioma. -tissue_expression_ns hsa-mir-29a Acquired Immunodeficiency Syndrome 28692540 Unique microRNA expression in the colonic mucosa during chronic HIV-1 infection. -tissue_expression_ns hsa-let-7a "Carcinoma, Renal Cell, Clear-Cell" 28694731 Detection of let-7 miRNAs in urine supernatant as potential diagnostic approach in non-metastatic clear-cell renal cell carcinoma. -tissue_expression_ns hsa-let-7b "Carcinoma, Renal Cell, Clear-Cell" 28694731 Detection of let-7 miRNAs in urine supernatant as potential diagnostic approach in non-metastatic clear-cell renal cell carcinoma. -tissue_expression_ns hsa-let-7d "Carcinoma, Renal Cell, Clear-Cell" 28694731 Detection of let-7 miRNAs in urine supernatant as potential diagnostic approach in non-metastatic clear-cell renal cell carcinoma. -tissue_expression_ns hsa-let-7e "Carcinoma, Renal Cell, Clear-Cell" 28694731 Detection of let-7 miRNAs in urine supernatant as potential diagnostic approach in non-metastatic clear-cell renal cell carcinoma. -tissue_expression_ns hsa-let-7g "Carcinoma, Renal Cell, Clear-Cell" 28694731 Detection of let-7 miRNAs in urine supernatant as potential diagnostic approach in non-metastatic clear-cell renal cell carcinoma. -tissue_expression_ns hsa-mir-126 "Carcinoma, Colon" 28714375 "The association of miR-126-3p, miR-126-5p and miR-664-3p expression profiles with outcomes of patients with metastatic colorectal cancer treated with bevacizumab." -tissue_expression_ns hsa-mir-664 "Carcinoma, Colon" 28714375 "The association of miR-126-3p, miR-126-5p and miR-664-3p expression profiles with outcomes of patients with metastatic colorectal cancer treated with bevacizumab." -tissue_expression_ns hsa-mir-146a Down Syndrome 28720071 Developmental Expression and Dysregulation of miR-146a and miR-155 in Down's Syndrome and Mouse Models of Down's Syndrome and Alzheimer's Disease. -tissue_expression_ns hsa-mir-155 Down Syndrome 28720071 Developmental Expression and Dysregulation of miR-146a and miR-155 in Down's Syndrome and Mouse Models of Down's Syndrome and Alzheimer's Disease. -tissue_expression_ns hsa-mir-204 "Carcinoma, Hepatocellular" 28746200 Promising significance of the association of miR-204-5p expression with clinicopathological features of hepatocellular carcinoma -tissue_expression_ns hsa-mir-130b Penis Carcinoma 28751665 "hsa-miR-31, hsa-miR-34a and hsa-miR-130b, were significantly associated with over-represented pathways in cancer" -tissue_expression_ns hsa-mir-31 Penis Carcinoma 28751665 "hsa-miR-31, hsa-miR-34a and hsa-miR-130b, were significantly associated with over-represented pathways in cancer" -tissue_expression_ns hsa-mir-34a Penis Carcinoma 28751665 "hsa-miR-31, hsa-miR-34a and hsa-miR-130b, were significantly associated with over-represented pathways in cancer" -tissue_expression_ns hsa-mir-29b Heart Failure 28765595 Integration of miRNA and mRNA expression profiles reveals microRNA-regulated networks during muscle wasting in cardiac cachexia. -tissue_expression_ns hsa-mir-145 Irritable Bowel Syndrome 28774781 "In all studied IBS samples disturbances in expression of cytokines IL-6, IL-10 and TNF-¦Á as well as miR-145, miR-148-5p and miR-592 were observed" -tissue_expression_ns hsa-mir-148 Irritable Bowel Syndrome 28774781 "In all studied IBS samples disturbances in expression of cytokines IL-6, IL-10 and TNF-¦Á as well as miR-145, miR-148-5p and miR-592 were observed" -tissue_expression_ns hsa-mir-592 Irritable Bowel Syndrome 28774781 "In all studied IBS samples disturbances in expression of cytokines IL-6, IL-10 and TNF-¦Á as well as miR-145, miR-148-5p and miR-592 were observed" -tissue_expression_ns hsa-mir-129 Sertoli Cell-Only Syndrome 28779347 "Among the highest differentially expressed miRNAs only seven, hsa-miR-34b, hsa-miR-34b*, hsa-miR-34c-5p, hsa-miR-449a, hsa-miR-449b*, hsa-miR-517b, and hsa-miR-129-3p, were shared by the three histopathological conditions and were strongly downregulated compared to the normal group " -tissue_expression_ns hsa-mir-34b Sertoli Cell-Only Syndrome 28779347 "Among the highest differentially expressed miRNAs only seven, hsa-miR-34b, hsa-miR-34b*, hsa-miR-34c-5p, hsa-miR-449a, hsa-miR-449b*, hsa-miR-517b, and hsa-miR-129-3p, were shared by the three histopathological conditions and were strongly downregulated compared to the normal group " -tissue_expression_ns hsa-mir-34c Sertoli Cell-Only Syndrome 28779347 "Among the highest differentially expressed miRNAs only seven, hsa-miR-34b, hsa-miR-34b*, hsa-miR-34c-5p, hsa-miR-449a, hsa-miR-449b*, hsa-miR-517b, and hsa-miR-129-3p, were shared by the three histopathological conditions and were strongly downregulated compared to the normal group " -tissue_expression_ns hsa-mir-449a Sertoli Cell-Only Syndrome 28779347 "Among the highest differentially expressed miRNAs only seven, hsa-miR-34b, hsa-miR-34b*, hsa-miR-34c-5p, hsa-miR-449a, hsa-miR-449b*, hsa-miR-517b, and hsa-miR-129-3p, were shared by the three histopathological conditions and were strongly downregulated compared to the normal group " -tissue_expression_ns hsa-mir-449b Sertoli Cell-Only Syndrome 28779347 "Among the highest differentially expressed miRNAs only seven, hsa-miR-34b, hsa-miR-34b*, hsa-miR-34c-5p, hsa-miR-449a, hsa-miR-449b*, hsa-miR-517b, and hsa-miR-129-3p, were shared by the three histopathological conditions and were strongly downregulated compared to the normal group " -tissue_expression_ns hsa-mir-517b Sertoli Cell-Only Syndrome 28779347 "Among the highest differentially expressed miRNAs only seven, hsa-miR-34b, hsa-miR-34b*, hsa-miR-34c-5p, hsa-miR-449a, hsa-miR-449b*, hsa-miR-517b, and hsa-miR-129-3p, were shared by the three histopathological conditions and were strongly downregulated compared to the normal group " -tissue_expression_ns hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 28799568 Association of long non-coding RNA H19 and microRNA-21 expression with the biological features and prognosis of non-small cell lung cancer. -tissue_expression_ns hsa-mir-21 Cardiovascular Diseases [unspecific] 28802862 MicroRNA-21: Expression in oligodendrocytes and correlation with low myelin mRNAs in depression and alcoholism. -tissue_expression_ns hsa-mir-223 Mastitis 28831974 Expression profiles of miRNAs from bovine mammary glands in response to Streptococcus agalactiae-induced mastitis. -tissue_expression_ns hsa-mir-375 "Carcinoma, Thyroid, Medullary" 28861609 MiR-375 and YAP1 expression profiling in medullary thyroid carcinoma and their correlation with clinical-pathological features and outcome. -tissue_expression_ns hsa-mir-10b Neoplasms [unspecific] 28864233 MicroRNA-10b and the clinical outcomes of various cancers: A systematic review and meta-analysis. -tissue_expression_ns hsa-mir-125a "Carcinoma, Hepatocellular" 28878257 Molecular mechanisms governing microRNA-125a expression in human hepatocellular carcinoma cells. -tissue_expression_ns hsa-mir-155 Breast Neoplasms 28882698 Prognostic value of microRNA-9 and microRNA-155 expression in triple-negative breast cancer -tissue_expression_ns hsa-mir-9 Breast Neoplasms 28882698 Prognostic value of microRNA-9 and microRNA-155 expression in triple-negative breast cancer -tissue_expression_ns hsa-mir-34c Infertility 28886318 New insights into the expression profile of MicroRNA-34c and P53 in infertile men spermatozoa and testicular tissue. -tissue_expression_ns hsa-mir-145 Pancreatic Adenocarcinoma 28903323 The pancreatic tumor microenvironment drives changes in miRNA expression that promote cytokine production and inhibit migration by the tumor associated stroma. -tissue_expression_ns hsa-mir-205 Pancreatic Adenocarcinoma 28903323 The pancreatic tumor microenvironment drives changes in miRNA expression that promote cytokine production and inhibit migration by the tumor associated stroma. -tissue_expression_ns hsa-mir-424 Skin Hemangioma 28928430 The expression and function of miR-424 in infantile skin hemangioma and its mechanism. -tissue_expression_ns hsa-mir-205 "Carcinoma, Nasopharyngeal" 28931826 MicroRNA profiling study reveals miR-150 in association with metastasis in nasopharyngeal carcinoma -tissue_expression_ns hsa-mir-34a "Carcinoma, Hepatocellular" 28950684 Deregulation of miR-34a and Its Chaperon Hsp70 in Hepatitis C virus-Induced Liver Cirrhosis and Hepatocellular Carcinoma Patients -tissue_expression_ns hsa-mir-200c "Squamous Cell Carcinoma, Sinonasal" 28960576 Deregulation of selected microRNAs in sinonasal carcinoma: Value of miR-21 as prognostic biomarker in sinonasal squamous cell carcinoma. -tissue_expression_ns hsa-mir-21 "Squamous Cell Carcinoma, Sinonasal" 28960576 Deregulation of selected microRNAs in sinonasal carcinoma: Value of miR-21 as prognostic biomarker in sinonasal squamous cell carcinoma. -tissue_expression_ns hsa-mir-125b "Carcinoma, Hepatocellular" 28984009 MicroRNA-125b expression and intrahepatic metastasis are predictors for early recurrence after hepatocellular carcinoma resection. -tissue_expression_ns hsa-mir-181a African Swine Fever 29041944 Differential expression of porcine microRNAs in African swine fever virus infected pigs: a proof-of-concept study. -tissue_expression_ns hsa-mir-21 Pancreatic Adenocarcinoma 29069873 These molecules are often aberrantly expressed and exhibit oncogenic and/or tumor suppressor functions in PDAC -tissue_expression_ns hsa-mir-143 Breast Neoplasms 29073169 Expression and function of the miR-143/145 cluster in vitro and in vivo in human breast cancer. -tissue_expression_ns hsa-mir-145 Breast Neoplasms 29073169 Expression and function of the miR-143/145 cluster in vitro and in vivo in human breast cancer. -tissue_expression_ns hsa-let-7a "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 29082244 "Expression Levels and Clinical Significance of miR-21-5p, miR-let-7a, and miR-34c-5p in Laryngeal Squamous Cell Carcinoma." -tissue_expression_ns hsa-mir-21 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 29082244 "Expression Levels and Clinical Significance of miR-21-5p, miR-let-7a, and miR-34c-5p in Laryngeal Squamous Cell Carcinoma." -tissue_expression_ns hsa-mir-34c "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 29082244 "Expression Levels and Clinical Significance of miR-21-5p, miR-let-7a, and miR-34c-5p in Laryngeal Squamous Cell Carcinoma." -tissue_expression_ns hsa-mir-1 "Adenocarcinoma, Pancreatic Ductal" 29085459 Abnormal alterations of miR-1 and miR-214 are associated with clinicopathological features and prognosis of patients with PDAC. -tissue_expression_ns hsa-mir-214 "Adenocarcinoma, Pancreatic Ductal" 29085459 Abnormal alterations of miR-1 and miR-214 are associated with clinicopathological features and prognosis of patients with PDAC. -tissue_expression_ns hsa-mir-203 "Carcinoma, Lung, Non-Small-Cell" 29088807 Identification of microRNA differentially expressed in three subtypes of non-small cell lung cancer and in silico functional analysis. -tissue_expression_ns hsa-mir-205 "Carcinoma, Lung, Non-Small-Cell" 29088807 Identification of microRNA differentially expressed in three subtypes of non-small cell lung cancer and in silico functional analysis. -tissue_expression_ns hsa-mir-375 "Carcinoma, Lung, Non-Small-Cell" 29088807 Identification of microRNA differentially expressed in three subtypes of non-small cell lung cancer and in silico functional analysis. -tissue_expression_ns hsa-mir-302a "Carcinoma, Mucoepidermoid" 29095552 miRNA expression profile of mucoepidermoid carcinoma. -tissue_expression_ns hsa-mir-10b Breast Neoplasms 29113216 miR-10b is a useful marker for predicting metastasis and angiogenesis in ANN breast cancer -tissue_expression_ns hsa-mir-372 "Adenocarcinoma, Gastric" 29135097 Analysis of expression profile of miRNA in stomach adenocarcinoma. -tissue_expression_ns hsa-mir-143 Colon Neoplasms 29152124 "The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p" -tissue_expression_ns hsa-mir-146a Colon Neoplasms 29152124 "The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p" -tissue_expression_ns hsa-mir-148a Colon Neoplasms 29152124 "The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p" -tissue_expression_ns hsa-mir-150 Colon Neoplasms 29152124 "The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p" -tissue_expression_ns hsa-mir-181a Colon Neoplasms 29152124 "The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p" -tissue_expression_ns hsa-mir-196a Colon Neoplasms 29152124 "The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p" -tissue_expression_ns hsa-mir-210 Colon Neoplasms 29152124 "The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p" -tissue_expression_ns hsa-mir-222 Colon Neoplasms 29152124 "The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p" -tissue_expression_ns hsa-mir-223 Colon Neoplasms 29152124 "The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p" -tissue_expression_ns hsa-mir-23a Colon Neoplasms 29152124 "The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p" -tissue_expression_ns hsa-mir-25 Colon Neoplasms 29152124 "The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p" -tissue_expression_ns hsa-mir-27a Colon Neoplasms 29152124 "The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p" -tissue_expression_ns hsa-mir-30b Colon Neoplasms 29152124 "The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p" -tissue_expression_ns hsa-mir-30c Colon Neoplasms 29152124 "The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p" -tissue_expression_ns hsa-mir-30d Colon Neoplasms 29152124 "The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p" -tissue_expression_ns hsa-mir-31 Colon Neoplasms 29152124 "The LASSO regression analysis identified a 16-miRNA signature including miR-143-5p, miR-27a-3p, miR-31-5p, miR-181a-5p, miR-30b-5p, miR-30d-5p, miR-146a-5p, miR-23a-3p, miR-150-5p, miR-210-3p, miR-25-3p, miR-196a-5p, miR-148a-3p, miR-222-3p, miR-30c-5p and miR-223-3p" -tissue_expression_ns hsa-mir-503 Breast Neoplasms 29164842 "miR-503 is expressed in numerous types of tumors such as breast cancer, prostate cancer, lung cancer, colorectal cancer, hepatocellular carcinoma, glioblastoma andseveral others" -tissue_expression_ns hsa-mir-503 "Carcinoma, Hepatocellular" 29164842 "miR-503 is expressed in numerous types of tumors such as breast cancer, prostate cancer, lung cancer, colorectal cancer, hepatocellular carcinoma, glioblastoma andseveral others" -tissue_expression_ns hsa-mir-503 Colorectal Carcinoma 29164842 "miR-503 is expressed in numerous types of tumors such as breast cancer, prostate cancer, lung cancer, colorectal cancer, hepatocellular carcinoma, glioblastoma andseveral others" -tissue_expression_ns hsa-mir-503 Glioblastoma 29164842 "miR-503 is expressed in numerous types of tumors such as breast cancer, prostate cancer, lung cancer, colorectal cancer, hepatocellular carcinoma, glioblastoma andseveral others" -tissue_expression_ns hsa-mir-503 Lung Neoplasms 29164842 "miR-503 is expressed in numerous types of tumors such as breast cancer, prostate cancer, lung cancer, colorectal cancer, hepatocellular carcinoma, glioblastoma andseveral others" -tissue_expression_ns hsa-mir-503 Prostate Neoplasms 29164842 "miR-503 is expressed in numerous types of tumors such as breast cancer, prostate cancer, lung cancer, colorectal cancer, hepatocellular carcinoma, glioblastoma andseveral others" -tissue_expression_ns hsa-mir-106b "Carcinoma, Hepatocellular" 29179453 MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis -tissue_expression_ns hsa-mir-126 "Carcinoma, Renal Cell, Clear-Cell" 29202733 Expression of micro-RNAs and genes related to angiogenesis in ccRCC and associations with tumor characteristics -tissue_expression_ns hsa-mir-200b "Carcinoma, Renal Cell, Clear-Cell" 29202733 Expression of micro-RNAs and genes related to angiogenesis in ccRCC and associations with tumor characteristics -tissue_expression_ns hsa-let-7a Periodontitis 29226952 "Differential expression of microRNAs let-7a, miR-125b, miR-100, and miR-21 and interaction with NF-kB pathway genes in periodontitis pathogenesis" -tissue_expression_ns hsa-mir-100 Periodontitis 29226952 "Differential expression of microRNAs let-7a, miR-125b, miR-100, and miR-21 and interaction with NF-kB pathway genes in periodontitis pathogenesis" -tissue_expression_ns hsa-mir-125b Periodontitis 29226952 "Differential expression of microRNAs let-7a, miR-125b, miR-100, and miR-21 and interaction with NF-kB pathway genes in periodontitis pathogenesis" -tissue_expression_ns hsa-mir-21 Periodontitis 29226952 "Differential expression of microRNAs let-7a, miR-125b, miR-100, and miR-21 and interaction with NF-kB pathway genes in periodontitis pathogenesis" -tissue_expression_ns hsa-mir-155 "Carcinoma, Hepatocellular" 29291025 "tissue miR-9, miR-21, miR-22, miR-29c, miR-34a, miR-34c, miR-155, miR-199a, miR-200a, miR-203, miR-221 and blood miR-21, miR-148a, miR-192, miR-224 demonstrate significantly prognostic value" -tissue_expression_ns hsa-mir-199a "Carcinoma, Hepatocellular" 29291025 "tissue miR-9, miR-21, miR-22, miR-29c, miR-34a, miR-34c, miR-155, miR-199a, miR-200a, miR-203, miR-221 and blood miR-21, miR-148a, miR-192, miR-224 demonstrate significantly prognostic value" -tissue_expression_ns hsa-mir-200a "Carcinoma, Hepatocellular" 29291025 "tissue miR-9, miR-21, miR-22, miR-29c, miR-34a, miR-34c, miR-155, miR-199a, miR-200a, miR-203, miR-221 and blood miR-21, miR-148a, miR-192, miR-224 demonstrate significantly prognostic value" -tissue_expression_ns hsa-mir-203 "Carcinoma, Hepatocellular" 29291025 "tissue miR-9, miR-21, miR-22, miR-29c, miR-34a, miR-34c, miR-155, miR-199a, miR-200a, miR-203, miR-221 and blood miR-21, miR-148a, miR-192, miR-224 demonstrate significantly prognostic value" -tissue_expression_ns hsa-mir-22 "Carcinoma, Hepatocellular" 29291025 "tissue miR-9, miR-21, miR-22, miR-29c, miR-34a, miR-34c, miR-155, miR-199a, miR-200a, miR-203, miR-221 and blood miR-21, miR-148a, miR-192, miR-224 demonstrate significantly prognostic value" -tissue_expression_ns hsa-mir-221 "Carcinoma, Hepatocellular" 29291025 "tissue miR-9, miR-21, miR-22, miR-29c, miR-34a, miR-34c, miR-155, miR-199a, miR-200a, miR-203, miR-221 and blood miR-21, miR-148a, miR-192, miR-224 demonstrate significantly prognostic value" -tissue_expression_ns hsa-mir-29c "Carcinoma, Hepatocellular" 29291025 "tissue miR-9, miR-21, miR-22, miR-29c, miR-34a, miR-34c, miR-155, miR-199a, miR-200a, miR-203, miR-221 and blood miR-21, miR-148a, miR-192, miR-224 demonstrate significantly prognostic value" -tissue_expression_ns hsa-mir-34a "Carcinoma, Hepatocellular" 29291025 "tissue miR-9, miR-21, miR-22, miR-29c, miR-34a, miR-34c, miR-155, miR-199a, miR-200a, miR-203, miR-221 and blood miR-21, miR-148a, miR-192, miR-224 demonstrate significantly prognostic value" -tissue_expression_ns hsa-mir-34c "Carcinoma, Hepatocellular" 29291025 "tissue miR-9, miR-21, miR-22, miR-29c, miR-34a, miR-34c, miR-155, miR-199a, miR-200a, miR-203, miR-221 and blood miR-21, miR-148a, miR-192, miR-224 demonstrate significantly prognostic value" -tissue_expression_ns hsa-mir-9 "Carcinoma, Hepatocellular" 29291025 "tissue miR-9, miR-21, miR-22, miR-29c, miR-34a, miR-34c, miR-155, miR-199a, miR-200a, miR-203, miR-221 and blood miR-21, miR-148a, miR-192, miR-224 demonstrate significantly prognostic value" -tissue_expression_ns hsa-mir-103a Vulvar Squamous Tumor 29299981 "Expression levels of six microRNAs-hsa-miR-425-5p, hsa-miR-191-5p, hsa-miR-93-5p, hsa-miR-423-5p, hsa-miR-103a-3p, and hsa-miR-16-5p-were analyzed by quantitative reverse transcription polymerase chain reaction in plasma samples" -tissue_expression_ns hsa-mir-16 Vulvar Squamous Tumor 29299981 "Expression levels of six microRNAs-hsa-miR-425-5p, hsa-miR-191-5p, hsa-miR-93-5p, hsa-miR-423-5p, hsa-miR-103a-3p, and hsa-miR-16-5p-were analyzed by quantitative reverse transcription polymerase chain reaction in plasma samples" -tissue_expression_ns hsa-mir-191 Vulvar Squamous Tumor 29299981 "Expression levels of six microRNAs-hsa-miR-425-5p, hsa-miR-191-5p, hsa-miR-93-5p, hsa-miR-423-5p, hsa-miR-103a-3p, and hsa-miR-16-5p-were analyzed by quantitative reverse transcription polymerase chain reaction in plasma samples" -tissue_expression_ns hsa-mir-423 Vulvar Squamous Tumor 29299981 "Expression levels of six microRNAs-hsa-miR-425-5p, hsa-miR-191-5p, hsa-miR-93-5p, hsa-miR-423-5p, hsa-miR-103a-3p, and hsa-miR-16-5p-were analyzed by quantitative reverse transcription polymerase chain reaction in plasma samples" -tissue_expression_ns hsa-mir-425 Vulvar Squamous Tumor 29299981 "Expression levels of six microRNAs-hsa-miR-425-5p, hsa-miR-191-5p, hsa-miR-93-5p, hsa-miR-423-5p, hsa-miR-103a-3p, and hsa-miR-16-5p-were analyzed by quantitative reverse transcription polymerase chain reaction in plasma samples" -tissue_expression_ns hsa-mir-93 Vulvar Squamous Tumor 29299981 "Expression levels of six microRNAs-hsa-miR-425-5p, hsa-miR-191-5p, hsa-miR-93-5p, hsa-miR-423-5p, hsa-miR-103a-3p, and hsa-miR-16-5p-were analyzed by quantitative reverse transcription polymerase chain reaction in plasma samples" -tissue_expression_ns hsa-let-7c Mitral Valve Disease 29315310 "Dysregulation of valvular interstitial cell let-7c, miR-17, miR-20a, and miR-30d in naturally occurring canine myxomatous mitral valve disease" -tissue_expression_ns hsa-mir-17 Mitral Valve Disease 29315310 "Dysregulation of valvular interstitial cell let-7c, miR-17, miR-20a, and miR-30d in naturally occurring canine myxomatous mitral valve disease" -tissue_expression_ns hsa-mir-20a Mitral Valve Disease 29315310 "Dysregulation of valvular interstitial cell let-7c, miR-17, miR-20a, and miR-30d in naturally occurring canine myxomatous mitral valve disease" -tissue_expression_ns hsa-mir-30d Mitral Valve Disease 29315310 "Dysregulation of valvular interstitial cell let-7c, miR-17, miR-20a, and miR-30d in naturally occurring canine myxomatous mitral valve disease" -tissue_expression_ns hsa-mir-186 Acute Peritonitis 29360196 "The data from the current study provide novel evidence of the differential expression of miRNAs in ascites from patients with PCA and SBP, which may offer an additional miRNA-based molecular approach for the differential diagnosis of PCA" -tissue_expression_ns hsa-mir-186 Peritoneal Neoplasms 29360196 "The data from the current study provide novel evidence of the differential expression of miRNAs in ascites from patients with PCA and SBP, which may offer an additional miRNA-based molecular approach for the differential diagnosis of PCA" -tissue_expression_ns hsa-mir-21 Acute Peritonitis 29360196 "The data from the current study provide novel evidence of the differential expression of miRNAs in ascites from patients with PCA and SBP, which may offer an additional miRNA-based molecular approach for the differential diagnosis of PCA" -tissue_expression_ns hsa-mir-21 Peritoneal Neoplasms 29360196 "The data from the current study provide novel evidence of the differential expression of miRNAs in ascites from patients with PCA and SBP, which may offer an additional miRNA-based molecular approach for the differential diagnosis of PCA" -tissue_expression_ns hsa-mir-222 Acute Peritonitis 29360196 "The data from the current study provide novel evidence of the differential expression of miRNAs in ascites from patients with PCA and SBP, which may offer an additional miRNA-based molecular approach for the differential diagnosis of PCA" -tissue_expression_ns hsa-mir-222 Peritoneal Neoplasms 29360196 "The data from the current study provide novel evidence of the differential expression of miRNAs in ascites from patients with PCA and SBP, which may offer an additional miRNA-based molecular approach for the differential diagnosis of PCA" -tissue_expression_ns hsa-mir-223 Acute Peritonitis 29360196 "The data from the current study provide novel evidence of the differential expression of miRNAs in ascites from patients with PCA and SBP, which may offer an additional miRNA-based molecular approach for the differential diagnosis of PCA" -tissue_expression_ns hsa-mir-223 Peritoneal Neoplasms 29360196 "The data from the current study provide novel evidence of the differential expression of miRNAs in ascites from patients with PCA and SBP, which may offer an additional miRNA-based molecular approach for the differential diagnosis of PCA" -tissue_expression_ns hsa-mir-483 Acute Peritonitis 29360196 "The data from the current study provide novel evidence of the differential expression of miRNAs in ascites from patients with PCA and SBP, which may offer an additional miRNA-based molecular approach for the differential diagnosis of PCA" -tissue_expression_ns hsa-mir-483 Peritoneal Neoplasms 29360196 "The data from the current study provide novel evidence of the differential expression of miRNAs in ascites from patients with PCA and SBP, which may offer an additional miRNA-based molecular approach for the differential diagnosis of PCA" -tissue_expression_ns hsa-let-7a Chronic Obstructive Pulmonary Disease 29371906 Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions -tissue_expression_ns hsa-let-7a Lung Neoplasms 29371906 Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions -tissue_expression_ns hsa-let-7c Chronic Obstructive Pulmonary Disease 29371906 Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions -tissue_expression_ns hsa-let-7c Lung Neoplasms 29371906 Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions -tissue_expression_ns hsa-mir-126 Chronic Obstructive Pulmonary Disease 29371906 Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions -tissue_expression_ns hsa-mir-126 Lung Neoplasms 29371906 Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions -tissue_expression_ns hsa-mir-155 Chronic Obstructive Pulmonary Disease 29371906 Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions -tissue_expression_ns hsa-mir-155 Lung Neoplasms 29371906 Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions -tissue_expression_ns hsa-mir-200b Chronic Obstructive Pulmonary Disease 29371906 Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions -tissue_expression_ns hsa-mir-200b Lung Neoplasms 29371906 Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions -tissue_expression_ns hsa-mir-21 Chronic Obstructive Pulmonary Disease 29371906 Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions -tissue_expression_ns hsa-mir-21 Lung Neoplasms 29371906 Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions -tissue_expression_ns hsa-mir-210 Chronic Obstructive Pulmonary Disease 29371906 Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions -tissue_expression_ns hsa-mir-210 Lung Neoplasms 29371906 Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions -tissue_expression_ns hsa-mir-30a Chronic Obstructive Pulmonary Disease 29371906 Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions -tissue_expression_ns hsa-mir-30a Lung Neoplasms 29371906 Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions -tissue_expression_ns hsa-mir-451 Chronic Obstructive Pulmonary Disease 29371906 Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions -tissue_expression_ns hsa-mir-451 Lung Neoplasms 29371906 Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions -tissue_expression_ns hsa-mir-135a Pituitary Adenoma 29374071 "elevant compensatory mechanisms were found through the changes in miR involved in osteoblastogenesis (miR-210-5p, miR-135a-5p, miR-211, miR-23a-3p, miR-204-5p)" -tissue_expression_ns hsa-mir-204 Pituitary Adenoma 29374071 "elevant compensatory mechanisms were found through the changes in miR involved in osteoblastogenesis (miR-210-5p, miR-135a-5p, miR-211, miR-23a-3p, miR-204-5p)" -tissue_expression_ns hsa-mir-210 Pituitary Adenoma 29374071 "elevant compensatory mechanisms were found through the changes in miR involved in osteoblastogenesis (miR-210-5p, miR-135a-5p, miR-211, miR-23a-3p, miR-204-5p)" -tissue_expression_ns hsa-mir-2110 Pituitary Adenoma 29374071 "elevant compensatory mechanisms were found through the changes in miR involved in osteoblastogenesis (miR-210-5p, miR-135a-5p, miR-211, miR-23a-3p, miR-204-5p)" -tissue_expression_ns hsa-mir-23a Pituitary Adenoma 29374071 "elevant compensatory mechanisms were found through the changes in miR involved in osteoblastogenesis (miR-210-5p, miR-135a-5p, miR-211, miR-23a-3p, miR-204-5p)" -tissue_expression_ns hsa-mir-200 "Squamous Cell Carcinoma, Oral" 29375721 Dysregulation of miR-200 family microRNAs and epithelial-mesenchymal transition markers in oral squamous cell carcinoma -tissue_expression_ns hsa-mir-15b Ovarian Disease 29377183 "miR-379, miR-15b, miR-691, miR-872 and miR-1897-5p are potentially useful markers of ovarian toxicity and dysfunction" -tissue_expression_ns hsa-mir-1897 Ovarian Disease 29377183 "miR-379, miR-15b, miR-691, miR-872 and miR-1897-5p are potentially useful markers of ovarian toxicity and dysfunction" -tissue_expression_ns hsa-mir-379 Ovarian Disease 29377183 "miR-379, miR-15b, miR-691, miR-872 and miR-1897-5p are potentially useful markers of ovarian toxicity and dysfunction" -tissue_expression_ns hsa-mir-691 Ovarian Disease 29377183 "miR-379, miR-15b, miR-691, miR-872 and miR-1897-5p are potentially useful markers of ovarian toxicity and dysfunction" -tissue_expression_ns hsa-mir-872 Ovarian Disease 29377183 "miR-379, miR-15b, miR-691, miR-872 and miR-1897-5p are potentially useful markers of ovarian toxicity and dysfunction" -tissue_expression_ns hsa-let-7b Ovarian Neoplasms 29385306 "RT-PCR revealed a significantly increased expression of ovarian miRNAs (let-7b, miR-17-5p miR-181a, and miR-151), which inhibit follicular granulosa cell proliferation" -tissue_expression_ns hsa-mir-151 Ovarian Neoplasms 29385306 "RT-PCR revealed a significantly increased expression of ovarian miRNAs (let-7b, miR-17-5p miR-181a, and miR-151), which inhibit follicular granulosa cell proliferation" -tissue_expression_ns hsa-mir-17 Ovarian Neoplasms 29385306 "RT-PCR revealed a significantly increased expression of ovarian miRNAs (let-7b, miR-17-5p miR-181a, and miR-151), which inhibit follicular granulosa cell proliferation" -tissue_expression_ns hsa-mir-181a Ovarian Neoplasms 29385306 "RT-PCR revealed a significantly increased expression of ovarian miRNAs (let-7b, miR-17-5p miR-181a, and miR-151), which inhibit follicular granulosa cell proliferation" -tissue_expression_ns hsa-mir-10b "Carcinoma, Thyroid, Anaplastic" 29397781 "These results demonstrate that IR deregulates microRNA expression, affecting the double-strand DNA breaks repair efficiency of irradiated thyroid cells, and suggest that miR-10b-5p overexpression may be an innovative approach for anaplastic thyroid cancer therapy by increasing cancer cell radiosensitivity." -tissue_expression_ns hsa-mir-146a Diabetic Peripheral Neuropathy 29398906 "miR-146a is involved in the pathogenesis of DPN, and its expression level is closely related to the inflammatory responses that aggravate sciatic nerve injuries" -tissue_expression_ns hsa-mir-200b "Carcinoma, Renal Cell" 29416756 "miR-126, miR-222 and miR-200b were significantly differentially expressed between the subtypes by in situ hybridization" -tissue_expression_ns hsa-mir-221 "Carcinoma, Renal Cell" 29416756 "miR-126, miR-222 and miR-201b were significantly differentially expressed between the subtypes by in situ hybridization" -tissue_expression_ns hsa-mir-222 "Carcinoma, Renal Cell" 29416756 "miR-126, miR-222 and miR-202b were significantly differentially expressed between the subtypes by in situ hybridization" -tissue_expression_ns hsa-mir-29b "Carcinoma, Breast" 29422258 miR-29b levels constitute a promising biomarker of favorable prognosis for patients with invasive ductal breast carcinoma -tissue_expression_ns hsa-mir-195 Adrenal Cortex Neoplasms 29429354 "Several tissue microRNAs, such as miR-483-5p, miR-503, miR-210, miR-335 and miR-195 were found to be differentially expressed among benign and malignant adrenocortical tumours" -tissue_expression_ns hsa-mir-210 Adrenal Cortex Neoplasms 29429354 "Several tissue microRNAs, such as miR-483-5p, miR-503, miR-210, miR-335 and miR-195 were found to be differentially expressed among benign and malignant adrenocortical tumours" -tissue_expression_ns hsa-mir-335 Adrenal Cortex Neoplasms 29429354 "Several tissue microRNAs, such as miR-483-5p, miR-503, miR-210, miR-335 and miR-195 were found to be differentially expressed among benign and malignant adrenocortical tumours" -tissue_expression_ns hsa-mir-483 Adrenal Cortex Neoplasms 29429354 "Several tissue microRNAs, such as miR-483-5p, miR-503, miR-210, miR-335 and miR-195 were found to be differentially expressed among benign and malignant adrenocortical tumours" -tissue_expression_ns hsa-mir-503 Adrenal Cortex Neoplasms 29429354 "Several tissue microRNAs, such as miR-483-5p, miR-503, miR-210, miR-335 and miR-195 were found to be differentially expressed among benign and malignant adrenocortical tumours" -tissue_expression_ns hsa-mir-222 "Carcinoma, Thyroid, Papillary" 29435194 miRNA dysregulation and the risk of metastasis and invasion in papillary thyroid cancer: a systematic review and meta-analysis -tissue_expression_ns hsa-mir-155 Lung Neoplasms 29437031 Underexpression of miR-486-5p but not Overexpression of miR-156 is Associated with Lung Cancer Stages -tissue_expression_ns hsa-mir-486 Lung Neoplasms 29437031 Underexpression of miR-486-5p but not Overexpression of miR-155 is Associated with Lung Cancer Stages -tissue_expression_ns hsa-mir-126 Parathyroid Carcinoma 29453660 "miR-139, miR-222, miR-30b, miR-517c, and miR-126* were differentially expressed between PCa and PAd." -tissue_expression_ns hsa-mir-139 Parathyroid Carcinoma 29453660 The combined analysis of miR-139 and miR-30b may be used as a potential diagnostic strategy for distinguishing Pca from PAd -tissue_expression_ns hsa-mir-222 Parathyroid Carcinoma 29453660 "miR-139, miR-222, miR-30b, miR-517c, and miR-126* were differentially expressed between PCa and PAd." -tissue_expression_ns hsa-mir-30b Parathyroid Carcinoma 29453660 The combined analysis of miR-139 and miR-31b may be used as a potential diagnostic strategy for distinguishing Pca from PAd -tissue_expression_ns hsa-mir-517c Parathyroid Carcinoma 29453660 "miR-139, miR-222, miR-30b, miR-517c, and miR-126* were differentially expressed between PCa and PAd." -tissue_expression_ns hsa-let-7i "Carcinoma, Nasopharyngeal" 29455649 "miR-142, miR-26a, miR-141 and let-7i have significant prognostic power" -tissue_expression_ns hsa-mir-141 "Carcinoma, Nasopharyngeal" 29455649 "miR-142, miR-26a, miR-141 and let-7i have significant prognostic power" -tissue_expression_ns hsa-mir-142 "Carcinoma, Nasopharyngeal" 29455649 "miR-142, miR-26a, miR-141 and let-7i have significant prognostic power" -tissue_expression_ns hsa-mir-26a "Carcinoma, Nasopharyngeal" 29455649 "miR-142, miR-26a, miR-141 and let-7i have significant prognostic power" -tissue_expression_ns hsa-mir-125b Breast Neoplasms 29483949 Differentially expressed miRNAs provide insights of this uncommon but highly aggressive pathology -tissue_expression_ns hsa-mir-101-1 Multiple Myeloma 29546453 "All these miRNAs were significantly over-expressed in patients vs controls (MIR-16-1, MIR-21, MIR-23A, MIR-28, MIR-101-1, MIR-124-1, MIR-129, MIR-139, MIR-145, MIR-149, MIR-202, MIR-221, MIR-424, MIR-520)" -tissue_expression_ns hsa-mir-124-1 Multiple Myeloma 29546453 "All these miRNAs were significantly over-expressed in patients vs controls (MIR-16-1, MIR-21, MIR-23A, MIR-28, MIR-101-1, MIR-124-1, MIR-129, MIR-139, MIR-145, MIR-149, MIR-202, MIR-221, MIR-424, MIR-520)" -tissue_expression_ns hsa-mir-129 Multiple Myeloma 29546453 "All these miRNAs were significantly over-expressed in patients vs controls (MIR-16-1, MIR-21, MIR-23A, MIR-28, MIR-101-1, MIR-124-1, MIR-129, MIR-139, MIR-145, MIR-149, MIR-202, MIR-221, MIR-424, MIR-520)" -tissue_expression_ns hsa-mir-139 Multiple Myeloma 29546453 "All these miRNAs were significantly over-expressed in patients vs controls (MIR-16-1, MIR-21, MIR-23A, MIR-28, MIR-101-1, MIR-124-1, MIR-129, MIR-139, MIR-145, MIR-149, MIR-202, MIR-221, MIR-424, MIR-520)" -tissue_expression_ns hsa-mir-145 Multiple Myeloma 29546453 "All these miRNAs were significantly over-expressed in patients vs controls (MIR-16-1, MIR-21, MIR-23A, MIR-28, MIR-101-1, MIR-124-1, MIR-129, MIR-139, MIR-145, MIR-149, MIR-202, MIR-221, MIR-424, MIR-520)" -tissue_expression_ns hsa-mir-149 Multiple Myeloma 29546453 "All these miRNAs were significantly over-expressed in patients vs controls (MIR-16-1, MIR-21, MIR-23A, MIR-28, MIR-101-1, MIR-124-1, MIR-129, MIR-139, MIR-145, MIR-149, MIR-202, MIR-221, MIR-424, MIR-520)" -tissue_expression_ns hsa-mir-16 Multiple Myeloma 29546453 "All these miRNAs were significantly over-expressed in patients vs controls (MIR-16-1, MIR-21, MIR-23A, MIR-28, MIR-101-1, MIR-124-1, MIR-129, MIR-139, MIR-145, MIR-149, MIR-202, MIR-221, MIR-424, MIR-520)" -tissue_expression_ns hsa-mir-202 Multiple Myeloma 29546453 "All these miRNAs were significantly over-expressed in patients vs controls (MIR-16-1, MIR-21, MIR-23A, MIR-28, MIR-101-1, MIR-124-1, MIR-129, MIR-139, MIR-145, MIR-149, MIR-202, MIR-221, MIR-424, MIR-520)" -tissue_expression_ns hsa-mir-21 Multiple Myeloma 29546453 "All these miRNAs were significantly over-expressed in patients vs controls (MIR-16-1, MIR-21, MIR-23A, MIR-28, MIR-101-1, MIR-124-1, MIR-129, MIR-139, MIR-145, MIR-149, MIR-202, MIR-221, MIR-424, MIR-520)" -tissue_expression_ns hsa-mir-221 Multiple Myeloma 29546453 "All these miRNAs were significantly over-expressed in patients vs controls (MIR-16-1, MIR-21, MIR-23A, MIR-28, MIR-101-1, MIR-124-1, MIR-129, MIR-139, MIR-145, MIR-149, MIR-202, MIR-221, MIR-424, MIR-520)" -tissue_expression_ns hsa-mir-23a Multiple Myeloma 29546453 "All these miRNAs were significantly over-expressed in patients vs controls (MIR-16-1, MIR-21, MIR-23A, MIR-28, MIR-101-1, MIR-124-1, MIR-129, MIR-139, MIR-145, MIR-149, MIR-202, MIR-221, MIR-424, MIR-520)" -tissue_expression_ns hsa-mir-28 Multiple Myeloma 29546453 "All these miRNAs were significantly over-expressed in patients vs controls (MIR-16-1, MIR-21, MIR-23A, MIR-28, MIR-101-1, MIR-124-1, MIR-129, MIR-139, MIR-145, MIR-149, MIR-202, MIR-221, MIR-424, MIR-520)" -tissue_expression_ns hsa-mir-424 Multiple Myeloma 29546453 "All these miRNAs were significantly over-expressed in patients vs controls (MIR-16-1, MIR-21, MIR-23A, MIR-28, MIR-101-1, MIR-124-1, MIR-129, MIR-139, MIR-145, MIR-149, MIR-202, MIR-221, MIR-424, MIR-520)" -tissue_expression_ns hsa-mir-520 Multiple Myeloma 29546453 "All these miRNAs were significantly over-expressed in patients vs controls (MIR-16-1, MIR-21, MIR-23A, MIR-28, MIR-101-1, MIR-124-1, MIR-129, MIR-139, MIR-145, MIR-149, MIR-202, MIR-221, MIR-424, MIR-520)" -tissue_expression_ns hsa-mir-15a "Carcinoma, Renal Cell" 29549624 MicroRNA-15a expression measured in urine samples as a potential biomarker of renal cell carcinoma. -tissue_expression_ns hsa-mir-191 "Carcinoma, Breast" 29555574 "4 miRNAs (miR-191-5p, miR-214-3p, miR-451a, and miR-489) were validated in a total of 159 patients including a training set" -tissue_expression_ns hsa-mir-214 "Carcinoma, Breast" 29555574 "4 miRNAs (miR-191-5p, miR-214-3p, miR-451a, and miR-489) were validated in a total of 159 patients including a training set" -tissue_expression_ns hsa-mir-451a "Carcinoma, Breast" 29555574 "4 miRNAs (miR-191-5p, miR-214-3p, miR-451a, and miR-489) were validated in a total of 159 patients including a training set" -tissue_expression_ns hsa-mir-489 "Carcinoma, Breast" 29555574 "4 miRNAs (miR-191-5p, miR-214-3p, miR-451a, and miR-489) were validated in a total of 159 patients including a training set" -tissue_expression_ns hsa-mir-1226 "Carcinoma, Breast" 29557813 whereas miR-342 and miR-1226 may be associated with tamoxifen resistance in breast cancer cells -tissue_expression_ns hsa-mir-342 "Carcinoma, Breast" 29557813 whereas miR-342 and miR-1226 may be associated with tamoxifen resistance in breast cancer cells -tissue_expression_ns hsa-mir-21 Colorectal Carcinoma 29564561 "The expression levels of miR-7 and -21 were up-regulated in non-granular type of laterally spreading tumor, UCAT, and SSA/P compared with those in polypoid and FAP tumors" -tissue_expression_ns hsa-mir-7 Colorectal Carcinoma 29564561 "The expression levels of miR-7 and -21 were up-regulated in non-granular type of laterally spreading tumor, UCAT, and SSA/P compared with those in polypoid and FAP tumors" -tissue_expression_ns hsa-mir-142 Uterine Corpus Endometrial Carcinoma 29567372 A six-microRNA signature predicts survival of patients with uterine corpus endometrial carcinoma. -tissue_expression_ns hsa-mir-146a Uterine Corpus Endometrial Carcinoma 29567372 A six-microRNA signature predicts survival of patients with uterine corpus endometrial carcinoma. -tissue_expression_ns hsa-mir-15a Uterine Corpus Endometrial Carcinoma 29567372 A six-microRNA signature predicts survival of patients with uterine corpus endometrial carcinoma. -tissue_expression_ns hsa-mir-1976 Uterine Corpus Endometrial Carcinoma 29567372 A six-microRNA signature predicts survival of patients with uterine corpus endometrial carcinoma. -tissue_expression_ns hsa-mir-3170 Uterine Corpus Endometrial Carcinoma 29567372 A six-microRNA signature predicts survival of patients with uterine corpus endometrial carcinoma. -tissue_expression_ns hsa-mir-135b Colorectal Carcinoma 29633600 "detection on miR-21, miR-135b, miR-31 and miR-20a levels in the tissue might be helpful to illuminate the molecular mechanisms underlying CRC carcinogenesis and serve as tumor-associated biomarkers for diagnosis" -tissue_expression_ns hsa-mir-20a Colorectal Carcinoma 29633600 "detection on miR-21, miR-135b, miR-31 and miR-20a levels in the tissue might be helpful to illuminate the molecular mechanisms underlying CRC carcinogenesis and serve as tumor-associated biomarkers for diagnosis" -tissue_expression_ns hsa-mir-21 Colorectal Carcinoma 29633600 "detection on miR-21, miR-135b, miR-31 and miR-20a levels in the tissue might be helpful to illuminate the molecular mechanisms underlying CRC carcinogenesis and serve as tumor-associated biomarkers for diagnosis" -tissue_expression_ns hsa-mir-31 Colorectal Carcinoma 29633600 "detection on miR-21, miR-135b, miR-31 and miR-20a levels in the tissue might be helpful to illuminate the molecular mechanisms underlying CRC carcinogenesis and serve as tumor-associated biomarkers for diagnosis" -tissue_expression_ns hsa-mir-1 Ischemia-Reperfusion Injury 29642230 "Most commonly reported miRNAs with differential expression between preconditioned and control groups include miR-1, miR-21 and miR-144" -tissue_expression_ns hsa-mir-144 Ischemia-Reperfusion Injury 29642230 "Most commonly reported miRNAs with differential expression between preconditioned and control groups include miR-1, miR-21 and miR-144" -tissue_expression_ns hsa-mir-21 Ischemia-Reperfusion Injury 29642230 "Most commonly reported miRNAs with differential expression between preconditioned and control groups include miR-1, miR-21 and miR-144" -tissue_expression_ns hsa-mir-371a Germ Cell Tumor 29685967 Germ cell tumour subtypes display differential expression of microRNA371a-3p. -tissue_expression_ns hsa-mir-128 Pediatric Ependymoma 29704232 "miR-543, miR-495-3p, miR-299-3p, miR-139-5p and miR-128-3p were identified to have CD44 positively co-regulated potential target oncogenes" -tissue_expression_ns hsa-mir-139 Pediatric Ependymoma 29704232 "miR-543, miR-495-3p, miR-299-3p, miR-139-5p and miR-128-3p were identified to have CD44 positively co-regulated potential target oncogenes" -tissue_expression_ns hsa-mir-299 Pediatric Ependymoma 29704232 "miR-543, miR-495-3p, miR-299-3p, miR-139-5p and miR-128-3p were identified to have CD44 positively co-regulated potential target oncogenes" -tissue_expression_ns hsa-mir-495 Pediatric Ependymoma 29704232 "miR-543, miR-495-3p, miR-299-3p, miR-139-5p and miR-128-3p were identified to have CD44 positively co-regulated potential target oncogenes" -tissue_expression_ns hsa-mir-543 Pediatric Ependymoma 29704232 "miR-543, miR-495-3p, miR-299-3p, miR-139-5p and miR-128-3p were identified to have CD44 positively co-regulated potential target oncogenes" -tissue_expression_ns hsa-mir-327 Parathyroid Carcinoma 29724878 The aberrantly expressed miR-372 partly impairs sensitivity to apoptosis in parathyroid tumor cells. -tissue_expression_ns hsa-mir-429 "Carcinoma, Bladder" 29747777 miR-429 expression in bladder cancer and its correlation with tumor behavior and clinical outcome. -tissue_expression_ns hsa-let-7b Thyroid Neoplasms 29762469 "The expression of miRNAs hsa-let-7f-5p, has-let-7b-5p hsa-miR-146b-5p and hsa-miR-146b-3p was modulated heterogeneously" -tissue_expression_ns hsa-let-7f Thyroid Neoplasms 29762469 "The expression of miRNAs hsa-let-7f-5p, has-let-7b-5p hsa-miR-146b-5p and hsa-miR-146b-3p was modulated heterogeneously" -tissue_expression_ns hsa-mir-146b Thyroid Neoplasms 29762469 "The expression of miRNAs hsa-let-7f-5p, has-let-7b-5p hsa-miR-146b-5p and hsa-miR-146b-3p was modulated heterogeneously" -tissue_expression_ns hsa-mir-493 "Carcinoma, Breast, Triple Negative" 29777630 MicroRNA-493 is a prognostic factor in triple-negative breast cancer. -tissue_expression_ns hsa-mir-34a Leukemia 29780367 Expression of miR-34a in T-Cells Infected by Human T-Lymphotropic Virus 1. -tissue_expression_ns hsa-mir-355 Hearing Disorders 29781875 "Most fluids showed expression of miR-355, miR-509p, miR-515p, miR-3p, miR-873, and miR-616, but also showed significant differences between the fluid types, suggesting that miRNA profiling may be used as a diagnostic tool" -tissue_expression_ns hsa-mir-509 Hearing Disorders 29781875 "Most fluids showed expression of miR-355, miR-509p, miR-515p, miR-3p, miR-873, and miR-616, but also showed significant differences between the fluid types, suggesting that miRNA profiling may be used as a diagnostic tool" -tissue_expression_ns hsa-mir-515 Hearing Disorders 29781875 "Most fluids showed expression of miR-355, miR-509p, miR-515p, miR-3p, miR-873, and miR-616, but also showed significant differences between the fluid types, suggesting that miRNA profiling may be used as a diagnostic tool" -tissue_expression_ns hsa-mir-616 Hearing Disorders 29781875 "Most fluids showed expression of miR-355, miR-509p, miR-515p, miR-3p, miR-873, and miR-616, but also showed significant differences between the fluid types, suggesting that miRNA profiling may be used as a diagnostic tool" -tissue_expression_ns hsa-mir-873 Hearing Disorders 29781875 "Most fluids showed expression of miR-355, miR-509p, miR-515p, miR-3p, miR-873, and miR-616, but also showed significant differences between the fluid types, suggesting that miRNA profiling may be used as a diagnostic tool" -tissue_expression_ns hsa-mir-153 "Carcinoma, Cervical" 29805649 Aberrant expression of miR-153 is associated with the poor prognosis of cervical cancer. -tissue_expression_ns hsa-mir-223 "Carcinoma, Breast" 29805680 Exosome-encapsulated microRNA-223-3p as a minimally invasive biomarker for the early detection of invasive breast cancer. -tissue_expression_ns hsa-let-7c Colon Neoplasms 29844680 "five hub miRNAs were identified to be related to prognosis (hsa-miR-125b-5p, hsa-miR-145-5p, hsa-let-7c-5p, hsa-miR-218-5p and hsa-miR-125b-2-3p)" -tissue_expression_ns hsa-mir-125b Colon Neoplasms 29844680 "five hub miRNAs were identified to be related to prognosis (hsa-miR-125b-5p, hsa-miR-145-5p, hsa-let-7c-5p, hsa-miR-218-5p and hsa-miR-125b-2-3p)" -tissue_expression_ns hsa-mir-145 Colon Neoplasms 29844680 "five hub miRNAs were identified to be related to prognosis (hsa-miR-125b-5p, hsa-miR-145-5p, hsa-let-7c-5p, hsa-miR-218-5p and hsa-miR-125b-2-3p)" -tissue_expression_ns hsa-mir-218 Colon Neoplasms 29844680 "five hub miRNAs were identified to be related to prognosis (hsa-miR-125b-5p, hsa-miR-145-5p, hsa-let-7c-5p, hsa-miR-218-5p and hsa-miR-125b-2-3p)" -tissue_expression_ns hsa-mir-10b Gastric Neoplasms 29848733 "Tumor Expression of miR-10b, miR-21, miR-143 and miR-145 Is Related to Clinicopathological Features of Gastric Cancer in a Central European Population." -tissue_expression_ns hsa-mir-143 Gastric Neoplasms 29848733 "Tumor Expression of miR-10b, miR-21, miR-143 and miR-145 Is Related to Clinicopathological Features of Gastric Cancer in a Central European Population." -tissue_expression_ns hsa-mir-145 Gastric Neoplasms 29848733 "Tumor Expression of miR-10b, miR-21, miR-143 and miR-145 Is Related to Clinicopathological Features of Gastric Cancer in a Central European Population." -tissue_expression_ns hsa-mir-21 Gastric Neoplasms 29848733 "Tumor Expression of miR-10b, miR-21, miR-143 and miR-145 Is Related to Clinicopathological Features of Gastric Cancer in a Central European Population." -tissue_expression_ns hsa-let-7a "Carcinoma, Lung, Non-Small-Cell" 29862540 We found that miR-21 and let-7a were significantly dysregulated in NSCLC patients -tissue_expression_ns hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 29862540 We found that miR-21 and let-7a were significantly dysregulated in NSCLC patients -tissue_expression_ns hsa-mir-185 Gastric Neoplasms 29879180 "The Zsummary algorithm identified an activated module (miR-486, miR-451, miR-185, and miR-600) which might serve as diagnostic biomarker of GC" -tissue_expression_ns hsa-mir-451 Gastric Neoplasms 29879180 "The Zsummary algorithm identified an activated module (miR-486, miR-451, miR-185, and miR-600) which might serve as diagnostic biomarker of GC" -tissue_expression_ns hsa-mir-486 Gastric Neoplasms 29879180 "The Zsummary algorithm identified an activated module (miR-486, miR-451, miR-185, and miR-600) which might serve as diagnostic biomarker of GC" -tissue_expression_ns hsa-mir-600 Gastric Neoplasms 29879180 "The Zsummary algorithm identified an activated module (miR-486, miR-451, miR-185, and miR-600) which might serve as diagnostic biomarker of GC" -tissue_expression_ns hsa-mir-146a Hepatoblastoma 29889802 "MicroRNA-17, MicroRNA-19b, MicroRNA-146a, MicroRNA-302d Expressions in Hepatoblastoma and Clinical Importance." -tissue_expression_ns hsa-mir-17 Hepatoblastoma 29889802 "MicroRNA-17, MicroRNA-19b, MicroRNA-146a, MicroRNA-302d Expressions in Hepatoblastoma and Clinical Importance." -tissue_expression_ns hsa-mir-19b Hepatoblastoma 29889802 "MicroRNA-17, MicroRNA-19b, MicroRNA-146a, MicroRNA-302d Expressions in Hepatoblastoma and Clinical Importance." -tissue_expression_ns hsa-mir-302d Hepatoblastoma 29889802 "MicroRNA-17, MicroRNA-19b, MicroRNA-146a, MicroRNA-302d Expressions in Hepatoblastoma and Clinical Importance." -tissue_expression_ns hsa-mir-106b "Carcinoma, Hepatocellular" 29899182 "In further analysis, eight miRNAs, including miR-4270, miR-125b-5p, miR-199a-3p, miR-10a-5p, miR-424-5p, miR-195-5p, miR-106b-5p and miR-3651, were retained" -tissue_expression_ns hsa-mir-10a "Carcinoma, Hepatocellular" 29899182 "In further analysis, eight miRNAs, including miR-4270, miR-125b-5p, miR-199a-3p, miR-10a-5p, miR-424-5p, miR-195-5p, miR-106b-5p and miR-3651, were retained" -tissue_expression_ns hsa-mir-125b "Carcinoma, Hepatocellular" 29899182 "In further analysis, eight miRNAs, including miR-4270, miR-125b-5p, miR-199a-3p, miR-10a-5p, miR-424-5p, miR-195-5p, miR-106b-5p and miR-3651, were retained" -tissue_expression_ns hsa-mir-195 "Carcinoma, Hepatocellular" 29899182 "In further analysis, eight miRNAs, including miR-4270, miR-125b-5p, miR-199a-3p, miR-10a-5p, miR-424-5p, miR-195-5p, miR-106b-5p and miR-3651, were retained" -tissue_expression_ns hsa-mir-199a "Carcinoma, Hepatocellular" 29899182 "In further analysis, eight miRNAs, including miR-4270, miR-125b-5p, miR-199a-3p, miR-10a-5p, miR-424-5p, miR-195-5p, miR-106b-5p and miR-3651, were retained" -tissue_expression_ns hsa-mir-3651 "Carcinoma, Hepatocellular" 29899182 "In further analysis, eight miRNAs, including miR-4270, miR-125b-5p, miR-199a-3p, miR-10a-5p, miR-424-5p, miR-195-5p, miR-106b-5p and miR-3651, were retained" -tissue_expression_ns hsa-mir-424 "Carcinoma, Hepatocellular" 29899182 "In further analysis, eight miRNAs, including miR-4270, miR-125b-5p, miR-199a-3p, miR-10a-5p, miR-424-5p, miR-195-5p, miR-106b-5p and miR-3651, were retained" -tissue_expression_ns hsa-mir-4270 "Carcinoma, Hepatocellular" 29899182 "In further analysis, eight miRNAs, including miR-4270, miR-125b-5p, miR-199a-3p, miR-10a-5p, miR-424-5p, miR-195-5p, miR-106b-5p and miR-3651, were retained" -tissue_expression_ns hsa-mir-155 "Squamous Cell Carcinoma, Tongue" 29909906 "MicroRNA-155, -185 and -193b as biomarkers in human papillomavirus positive and negative tonsillar and base of tongue squamous cell carcinoma." -tissue_expression_ns hsa-mir-185 "Squamous Cell Carcinoma, Tongue" 29909906 "MicroRNA-155, -185 and -193b as biomarkers in human papillomavirus positive and negative tonsillar and base of tongue squamous cell carcinoma." -tissue_expression_ns hsa-mir-193b "Squamous Cell Carcinoma, Tongue" 29909906 "MicroRNA-155, -185 and -193b as biomarkers in human papillomavirus positive and negative tonsillar and base of tongue squamous cell carcinoma." -tissue_expression_ns hsa-mir-146 "Squamous Cell Carcinoma, Oral" 29914173 altered expression of miR-146a and miR-191 was also observed in regenerative areas after OSCC resection -tissue_expression_ns hsa-mir-191 "Squamous Cell Carcinoma, Oral" 29914173 altered expression of miR-146a and miR-191 was also observed in regenerative areas after OSCC resection -tissue_expression_ns hsa-mir-1252 "Squamous Cell Carcinoma, Head and Neck" 29927717 "The differential expression profiles of these reporter biomolecules were cross-validated by independent RNA-Seq and miRNA-Seq datasets, and risk discrimination performance of the reporter biomolecules, BLNK, CCL2, E4F1, FOSL1, ISG15, MMP9, MYCN, MYH11, miR-1252, miR-29b, miR-29c, miR-3610, miR-431, and miR-523, was also evaluated" -tissue_expression_ns hsa-mir-29b "Squamous Cell Carcinoma, Head and Neck" 29927717 "The differential expression profiles of these reporter biomolecules were cross-validated by independent RNA-Seq and miRNA-Seq datasets, and risk discrimination performance of the reporter biomolecules, BLNK, CCL2, E4F1, FOSL1, ISG15, MMP9, MYCN, MYH11, miR-1252, miR-29b, miR-29c, miR-3610, miR-431, and miR-523, was also evaluated" -tissue_expression_ns hsa-mir-29c "Squamous Cell Carcinoma, Head and Neck" 29927717 "The differential expression profiles of these reporter biomolecules were cross-validated by independent RNA-Seq and miRNA-Seq datasets, and risk discrimination performance of the reporter biomolecules, BLNK, CCL2, E4F1, FOSL1, ISG15, MMP9, MYCN, MYH11, miR-1252, miR-29b, miR-29c, miR-3610, miR-431, and miR-523, was also evaluated" -tissue_expression_ns hsa-mir-3610 "Squamous Cell Carcinoma, Head and Neck" 29927717 "The differential expression profiles of these reporter biomolecules were cross-validated by independent RNA-Seq and miRNA-Seq datasets, and risk discrimination performance of the reporter biomolecules, BLNK, CCL2, E4F1, FOSL1, ISG15, MMP9, MYCN, MYH11, miR-1252, miR-29b, miR-29c, miR-3610, miR-431, and miR-523, was also evaluated" -tissue_expression_ns hsa-mir-431 "Squamous Cell Carcinoma, Head and Neck" 29927717 "The differential expression profiles of these reporter biomolecules were cross-validated by independent RNA-Seq and miRNA-Seq datasets, and risk discrimination performance of the reporter biomolecules, BLNK, CCL2, E4F1, FOSL1, ISG15, MMP9, MYCN, MYH11, miR-1252, miR-29b, miR-29c, miR-3610, miR-431, and miR-523, was also evaluated" -tissue_expression_ns hsa-mir-523 "Squamous Cell Carcinoma, Head and Neck" 29927717 "The differential expression profiles of these reporter biomolecules were cross-validated by independent RNA-Seq and miRNA-Seq datasets, and risk discrimination performance of the reporter biomolecules, BLNK, CCL2, E4F1, FOSL1, ISG15, MMP9, MYCN, MYH11, miR-1252, miR-29b, miR-29c, miR-3610, miR-431, and miR-523, was also evaluated" -tissue_expression_ns hsa-mir-133a Colon Neoplasms 29930763 Extensive screening of microRNA populations identifies hsa-miR-375 and hsa-miR-133a-3p as selective markers for human rectal and colon cancer. -tissue_expression_ns hsa-mir-133a Rectal Neoplasms 29930763 Extensive screening of microRNA populations identifies hsa-miR-375 and hsa-miR-133a-3p as selective markers for human rectal and colon cancer. -tissue_expression_ns hsa-mir-375 Colon Neoplasms 29930763 Extensive screening of microRNA populations identifies hsa-miR-375 and hsa-miR-133a-3p as selective markers for human rectal and colon cancer. -tissue_expression_ns hsa-mir-375 Rectal Neoplasms 29930763 Extensive screening of microRNA populations identifies hsa-miR-375 and hsa-miR-133a-3p as selective markers for human rectal and colon cancer. -tissue_expression_ns hsa-mir-221 Liver Fibrosis 29932949 miRNA-221 and miRNA-222 are promising biomarkers for progression of liver fibrosis in HCV Egyptian patients. -tissue_expression_ns hsa-mir-222 Liver Fibrosis 29932949 miRNA-221 and miRNA-222 are promising biomarkers for progression of liver fibrosis in HCV Egyptian patients. -tissue_expression_ns hsa-mir-21 Glioma 29949235 MicroRNAs as potential biomarkers for the diagnosis of c: A systematic review and meta-analysis. -tissue_expression_ns hsa-mir-548c Rectal Neoplasms 29956755 "Among these differentially expressed miRNAs, miR?548c?5p, miR?548d?5p and miR?663a were significantly associated with a CR to nCRT" -tissue_expression_ns hsa-mir-548d Rectal Neoplasms 29956755 "Among these differentially expressed miRNAs, miR?548c?5p, miR?548d?5p and miR?663a were significantly associated with a CR to nCRT" -tissue_expression_ns hsa-mir-663a Rectal Neoplasms 29956755 "Among these differentially expressed miRNAs, miR?548c?5p, miR?548d?5p and miR?663a were significantly associated with a CR to nCRT" -tissue_expression_ns hsa-mir-299 "Carcinoma, Hepatocellular" 29963149 Prognostic value of hsa-mir-299 and hsa-mir-7706 in hepatocellular carcinoma. -tissue_expression_ns hsa-mir-7706 "Carcinoma, Hepatocellular" 29963149 Prognostic value of hsa-mir-299 and hsa-mir-7706 in hepatocellular carcinoma. -tissue_expression_ns hsa-mir-145 "Squamous Cell Carcinoma, Esophageal" 29963194 "3 types of miRNA (miR-21, miR-25 and miR-145) in serum could serve as potential biomarkers for ESCC" -tissue_expression_ns hsa-mir-21 "Squamous Cell Carcinoma, Esophageal" 29963194 "3 types of miRNA (miR-21, miR-25 and miR-145) in serum could serve as potential biomarkers for ESCC" -tissue_expression_ns hsa-mir-25 "Squamous Cell Carcinoma, Esophageal" 29963194 "3 types of miRNA (miR-21, miR-25 and miR-145) in serum could serve as potential biomarkers for ESCC" -tissue_expression_ns hsa-mir-4758 Ganglioglioma 29963264 MicroRNA519d and microRNA4758 can identify gangliogliomas from dysembryoplastic neuroepithelial tumours and astrocytomas. -tissue_expression_ns hsa-mir-519d Ganglioglioma 29963264 MicroRNA519d and microRNA4758 can identify gangliogliomas from dysembryoplastic neuroepithelial tumours and astrocytomas. -tissue_expression_ns hsa-mir-122 Liver Injury 29963269 Mining of potential microRNAs with clinical correlation - regulation of syndecan-1 expression by miR-122-5p altered mobility of breast cancer cells and possible correlation with liver injury. -tissue_expression_ns hsa-mir-34a Amyotrophic Lateral Sclerosis 29973608 "miR-34a and miR504 appeared particularly relevant due to their involvement in the p53 pathway, synaptic vesicle regulation and general involvement in neurodegenerative diseases" -tissue_expression_ns hsa-mir-504 Amyotrophic Lateral Sclerosis 29973608 "miR-34a and miR504 appeared particularly relevant due to their involvement in the p53 pathway, synaptic vesicle regulation and general involvement in neurodegenerative diseases" -tissue_expression_ns hsa-mir-135b Oral Neoplasms 29976158 "Differential expression of hsa-miR-221, hsa-miR-21, hsa-miR-135b, and hsa-miR-29c suggests a field effect in oral cancer." -tissue_expression_ns hsa-mir-21 Oral Neoplasms 29976158 "Differential expression of hsa-miR-221, hsa-miR-21, hsa-miR-135b, and hsa-miR-29c suggests a field effect in oral cancer." -tissue_expression_ns hsa-mir-221 Oral Neoplasms 29976158 "Differential expression of hsa-miR-221, hsa-miR-21, hsa-miR-135b, and hsa-miR-29c suggests a field effect in oral cancer." -tissue_expression_ns hsa-mir-29c Oral Neoplasms 29976158 "Differential expression of hsa-miR-221, hsa-miR-21, hsa-miR-135b, and hsa-miR-29c suggests a field effect in oral cancer." -tissue_expression_ns hsa-mir-15a Lung Neoplasms 29980036 "Hsa-miR-197-3p, hsa-miR-29a-3p, hsa-miR-15a-5p, hsa-miR-16-5p and hsa-miR-92a-3p are found significantly expressed in association with exposures" -tissue_expression_ns hsa-mir-16 Lung Neoplasms 29980036 "Hsa-miR-197-3p, hsa-miR-29a-3p, hsa-miR-15a-5p, hsa-miR-16-5p and hsa-miR-92a-3p are found significantly expressed in association with exposures" -tissue_expression_ns hsa-mir-197 Lung Neoplasms 29980036 "Hsa-miR-197-3p, hsa-miR-29a-3p, hsa-miR-15a-5p, hsa-miR-16-5p and hsa-miR-92a-3p are found significantly expressed in association with exposures" -tissue_expression_ns hsa-mir-29a Lung Neoplasms 29980036 "Hsa-miR-197-3p, hsa-miR-29a-3p, hsa-miR-15a-5p, hsa-miR-16-5p and hsa-miR-92a-3p are found significantly expressed in association with exposures" -tissue_expression_ns hsa-mir-92a Lung Neoplasms 29980036 "Hsa-miR-197-3p, hsa-miR-29a-3p, hsa-miR-15a-5p, hsa-miR-16-5p and hsa-miR-92a-3p are found significantly expressed in association with exposures" -tissue_expression_ns hsa-mir-320 Chronic Obstructive Pulmonary Disease 29981854 Genome-wide MicroRNA Expression Profiles in COPD: Early Predictors for Cancer Development. -tissue_expression_ns hsa-mir-483 Adrenal Cortex Neoplasms 29982598 The lack of significantly different expression of hsa-miR-483-3p and hsa-miR-483-5p between AML and ACC might limit their applicability as diagnostic miRNA markers for ACC -tissue_expression_ns hsa-let-7a "Carcinoma, Breast" 29995098 Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer. -tissue_expression_ns hsa-mir-195 "Carcinoma, Breast" 29995098 Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer. -tissue_expression_ns hsa-mir-99a Prostate Neoplasms 29997385 Expression of microRNA-99a-3p in Prostate Cancer Based on Bioinformatics Data and Meta-Analysis of a Literature Review of 965 Cases. -tissue_expression_ns hsa-mir-141 "Carcinoma, Renal Cell" 30008851 miR-224/miR-141 ratio as a novel diagnostic biomarker in renal cell carcinoma. -tissue_expression_ns hsa-mir-224 "Carcinoma, Renal Cell" 30008851 miR-224/miR-141 ratio as a novel diagnostic biomarker in renal cell carcinoma. -tissue_expression_ns hsa-mir-141 Prostate Neoplasms 30014459 "Combination of three miRNA (miR-141, miR-21, and miR-375) as potential diagnostic tool for prostate cancer recognition." -tissue_expression_ns hsa-mir-21 Prostate Neoplasms 30014459 "Combination of three miRNA (miR-141, miR-21, and miR-375) as potential diagnostic tool for prostate cancer recognition." -tissue_expression_ns hsa-mir-375 Prostate Neoplasms 30014459 "Combination of three miRNA (miR-141, miR-21, and miR-375) as potential diagnostic tool for prostate cancer recognition." -tissue_expression_ns hsa-mir-18a Colorectal Carcinoma 30018727 miR-18a-5p functioned as an oncogene and prognostic biomarker in RCC -tissue_expression_ns hsa-let-7a "Carcinoma, Breast" 30019863 Differential altered expression of let-7a and miR-205 tumor-suppressor miRNAs in different subtypes of breast cancer under treatment with Taxol. -tissue_expression_ns hsa-mir-205 "Carcinoma, Breast" 30019863 Differential altered expression of let-7a and miR-205 tumor-suppressor miRNAs in different subtypes of breast cancer under treatment with Taxol. -tissue_expression_ns hsa-mir-200b "Adenocarcinoma, Lung" 30022565 Altered editing level of microRNAs is a potential biomarker in lung adenocarcinoma. -tissue_expression_ns hsa-mir-99a "Adenocarcinoma, Lung" 30022565 Altered editing level of microRNAs is a potential biomarker in lung adenocarcinoma. -tissue_expression_ns hsa-mir-33 Coronary Artery Disease 30022694 Circulating miRNA-33: a potential biomarker in patients with Coronary Artery Disease (CAD). -tissue_expression_ns hsa-mir-221 Osteosarcoma 30024497 MiRNA-221 from tissue may predict the prognosis of patients with osteosarcoma. -tissue_expression_ns hsa-mir-184 Glaucoma 30025119 "Relative expression patterns of hsa-miR-184, hsa-miR-486-5p, and hsa-miR-93-5p were confirmed by quantitative PCR" -tissue_expression_ns hsa-mir-486 Glaucoma 30025119 "Relative expression patterns of hsa-miR-184, hsa-miR-486-5p, and hsa-miR-93-5p were confirmed by quantitative PCR" -tissue_expression_ns hsa-mir-93 Glaucoma 30025119 "Relative expression patterns of hsa-miR-184, hsa-miR-486-5p, and hsa-miR-93-5p were confirmed by quantitative PCR" -tissue_expression_ns hsa-let-7g "Carcinoma, Hepatocellular" 30026054 "A number of miRNAs implicated in HCC, including miR-101, miR-140, miR-152, miR-199a-3p, and let-7g, were downregulated in CHB" -tissue_expression_ns hsa-mir-101 "Carcinoma, Hepatocellular" 30026054 "A number of miRNAs implicated in HCC, including miR-101, miR-140, miR-152, miR-199a-3p, and let-7g, were downregulated in CHB" -tissue_expression_ns hsa-mir-140 "Carcinoma, Hepatocellular" 30026054 "A number of miRNAs implicated in HCC, including miR-101, miR-140, miR-152, miR-199a-3p, and let-7g, were downregulated in CHB" -tissue_expression_ns hsa-mir-152 "Carcinoma, Hepatocellular" 30026054 "A number of miRNAs implicated in HCC, including miR-101, miR-140, miR-152, miR-199a-3p, and let-7g, were downregulated in CHB" -tissue_expression_ns hsa-mir-199a "Carcinoma, Hepatocellular" 30026054 "A number of miRNAs implicated in HCC, including miR-101, miR-140, miR-152, miR-199a-3p, and let-7g, were downregulated in CHB" -tissue_expression_ns hsa-mir-100 "Carcinoma, Urothelial" 30026881 "six were associated with high risk (hsa-miR-99a-5p, hsa-miR-100-5p, hsa-miR-125b-5p, hsa-miR-4324, hsa-miR-34b-5p, and hsa-miR-135a-3p) and three were shown to be protective (hsa-miR-145-5p, hsa-miR-29c-3p, and hsa-miR-33b-3p)" -tissue_expression_ns hsa-mir-125b "Carcinoma, Urothelial" 30026881 "six were associated with high risk (hsa-miR-99a-5p, hsa-miR-100-5p, hsa-miR-125b-5p, hsa-miR-4324, hsa-miR-34b-5p, and hsa-miR-135a-3p) and three were shown to be protective (hsa-miR-145-5p, hsa-miR-29c-3p, and hsa-miR-33b-3p)" -tissue_expression_ns hsa-mir-135a "Carcinoma, Urothelial" 30026881 "six were associated with high risk (hsa-miR-99a-5p, hsa-miR-100-5p, hsa-miR-125b-5p, hsa-miR-4324, hsa-miR-34b-5p, and hsa-miR-135a-3p) and three were shown to be protective (hsa-miR-145-5p, hsa-miR-29c-3p, and hsa-miR-33b-3p)" -tissue_expression_ns hsa-mir-145 "Carcinoma, Urothelial" 30026881 "six were associated with high risk (hsa-miR-99a-5p, hsa-miR-100-5p, hsa-miR-125b-5p, hsa-miR-4324, hsa-miR-34b-5p, and hsa-miR-135a-3p) and three were shown to be protective (hsa-miR-145-5p, hsa-miR-29c-3p, and hsa-miR-33b-3p)" -tissue_expression_ns hsa-mir-29c "Carcinoma, Urothelial" 30026881 "six were associated with high risk (hsa-miR-99a-5p, hsa-miR-100-5p, hsa-miR-125b-5p, hsa-miR-4324, hsa-miR-34b-5p, and hsa-miR-135a-3p) and three were shown to be protective (hsa-miR-145-5p, hsa-miR-29c-3p, and hsa-miR-33b-3p)" -tissue_expression_ns hsa-mir-33b "Carcinoma, Urothelial" 30026881 "six were associated with high risk (hsa-miR-99a-5p, hsa-miR-100-5p, hsa-miR-125b-5p, hsa-miR-4324, hsa-miR-34b-5p, and hsa-miR-135a-3p) and three were shown to be protective (hsa-miR-145-5p, hsa-miR-29c-3p, and hsa-miR-33b-3p)" -tissue_expression_ns hsa-mir-34b "Carcinoma, Urothelial" 30026881 "six were associated with high risk (hsa-miR-99a-5p, hsa-miR-100-5p, hsa-miR-125b-5p, hsa-miR-4324, hsa-miR-34b-5p, and hsa-miR-135a-3p) and three were shown to be protective (hsa-miR-145-5p, hsa-miR-29c-3p, and hsa-miR-33b-3p)" -tissue_expression_ns hsa-mir-4324 "Carcinoma, Urothelial" 30026881 "six were associated with high risk (hsa-miR-99a-5p, hsa-miR-100-5p, hsa-miR-125b-5p, hsa-miR-4324, hsa-miR-34b-5p, and hsa-miR-135a-3p) and three were shown to be protective (hsa-miR-145-5p, hsa-miR-29c-3p, and hsa-miR-33b-3p)" -tissue_expression_ns hsa-mir-99a "Carcinoma, Urothelial" 30026881 "six were associated with high risk (hsa-miR-99a-5p, hsa-miR-100-5p, hsa-miR-125b-5p, hsa-miR-4324, hsa-miR-34b-5p, and hsa-miR-135a-3p) and three were shown to be protective (hsa-miR-145-5p, hsa-miR-29c-3p, and hsa-miR-33b-3p)" -tissue_expression_ns hsa-mir-143 Prostate Neoplasms 30027097 "MicroRNAs like miR-23b, miR-95, miR-143, and miR-183 can be utilized in assisting the diagnosis and prognosis of prostate cancer as biomarkers" -tissue_expression_ns hsa-mir-183 Prostate Neoplasms 30027097 "MicroRNAs like miR-23b, miR-95, miR-143, and miR-183 can be utilized in assisting the diagnosis and prognosis of prostate cancer as biomarkers" -tissue_expression_ns hsa-mir-23b Prostate Neoplasms 30027097 "MicroRNAs like miR-23b, miR-95, miR-143, and miR-183 can be utilized in assisting the diagnosis and prognosis of prostate cancer as biomarkers" -tissue_expression_ns hsa-mir-95 Prostate Neoplasms 30027097 "MicroRNAs like miR-23b, miR-95, miR-143, and miR-183 can be utilized in assisting the diagnosis and prognosis of prostate cancer as biomarkers" -tissue_expression_ns hsa-mir-141 Prostate Neoplasms 30037718 "The refined miRNA panel (KCa-6: miR-27b, -942, -497, -144, -141 and -27a) was more capable of predicting the overall survival than was any single miRNAs included in it" -tissue_expression_ns hsa-mir-144 Prostate Neoplasms 30037718 "The refined miRNA panel (KCa-6: miR-27b, -942, -497, -144, -141 and -27a) was more capable of predicting the overall survival than was any single miRNAs included in it" -tissue_expression_ns hsa-mir-27a Prostate Neoplasms 30037718 "The refined miRNA panel (KCa-6: miR-27b, -942, -497, -144, -141 and -27a) was more capable of predicting the overall survival than was any single miRNAs included in it" -tissue_expression_ns hsa-mir-27b Prostate Neoplasms 30037718 "The refined miRNA panel (KCa-6: miR-27b, -942, -497, -144, -141 and -27a) was more capable of predicting the overall survival than was any single miRNAs included in it" -tissue_expression_ns hsa-mir-497 Prostate Neoplasms 30037718 "The refined miRNA panel (KCa-6: miR-27b, -942, -497, -144, -141 and -27a) was more capable of predicting the overall survival than was any single miRNAs included in it" -tissue_expression_ns hsa-mir-942 Prostate Neoplasms 30037718 "The refined miRNA panel (KCa-6: miR-27b, -942, -497, -144, -141 and -27a) was more capable of predicting the overall survival than was any single miRNAs included in it" -tissue_expression_ns hsa-mir-185 Asthma 30040124 Asthma diagnosis using integrated analysis of eosinophil microRNAs. -tissue_expression_ns hsa-mir-21 Cholangiocarcinoma 30050323 miR-21 may be a promising biomarker for diagnosis and prognosis of CCA -tissue_expression_ns hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 30050938 Multiple miRNAs such as miR-21 and miR-210 could be used as diagnostic tools for NSCLC -tissue_expression_ns hsa-mir-210 "Carcinoma, Lung, Non-Small-Cell" 30050938 Multiple miRNAs such as miR-21 and miR-210 could be used as diagnostic tools for NSCLC -tissue_expression_ns hsa-mir-139 "Carcinoma, Breast" 30055304 "Tree-based machine learning modelstrained in my analysis used hsa-miR-139 with hsa-miR-183 to classify breast tumors from normal samples, and hsa-miR4728 with hsa-miR190b to further classify these tumors into three major subtypes of breast cancer" -tissue_expression_ns hsa-mir-183 "Carcinoma, Breast" 30055304 "Tree-based machine learning modelstrained in my analysis used hsa-miR-139 with hsa-miR-183 to classify breast tumors from normal samples, and hsa-miR4728 with hsa-miR190b to further classify these tumors into three major subtypes of breast cancer" -tissue_expression_ns hsa-mir-1296 "Carcinoma, Hepatocellular" 30064138 "four miRNAs (mir-1296, mir-23c, mir-149, and mir-95) were finally selected for further validation and analysis" -tissue_expression_ns hsa-mir-149 "Carcinoma, Hepatocellular" 30064138 "four miRNAs (mir-1296, mir-23c, mir-149, and mir-95) were finally selected for further validation and analysis" -tissue_expression_ns hsa-mir-23c "Carcinoma, Hepatocellular" 30064138 "four miRNAs (mir-1296, mir-23c, mir-149, and mir-95) were finally selected for further validation and analysis" -tissue_expression_ns hsa-mir-95 "Carcinoma, Hepatocellular" 30064138 "four miRNAs (mir-1296, mir-23c, mir-149, and mir-95) were finally selected for further validation and analysis" -tissue_expression_ns hsa-mir-99a "Squamous Cell Carcinoma, Head and Neck" 30087832 our study may provide insights into the expression and mechanism of miR-99a-5p in HNSCC -tissue_expression_ns hsa-mir-155 "Carcinoma, Breast" 30088260 "metformin may modulate the pro-apoptotic Bax, anti-apoptotic Bcl-2, MMP-2, MMP-9, miR-21 and miR-155 expression levels. These findings may be instrumental for the clinical management and/or (targeted) treatment of breast cancer" -tissue_expression_ns hsa-mir-21 "Carcinoma, Breast" 30088260 "metformin may modulate the pro-apoptotic Bax, anti-apoptotic Bcl-2, MMP-2, MMP-9, miR-21 and miR-155 expression levels. These findings may be instrumental for the clinical management and/or (targeted) treatment of breast cancer" -tissue_expression_ns hsa-mir-17 Lung Neoplasms 30089594 "six microRNAs (miR-17, miR-190b, miR-19a, miR-19b, miR-26b, and miR-375) provided high diagnostic accuracy in discriminating lung cancer patients from healthy individuals" -tissue_expression_ns hsa-mir-190b Lung Neoplasms 30089594 "six microRNAs (miR-17, miR-190b, miR-19a, miR-19b, miR-26b, and miR-375) provided high diagnostic accuracy in discriminating lung cancer patients from healthy individuals" -tissue_expression_ns hsa-mir-19a Lung Neoplasms 30089594 "six microRNAs (miR-17, miR-190b, miR-19a, miR-19b, miR-26b, and miR-375) provided high diagnostic accuracy in discriminating lung cancer patients from healthy individuals" -tissue_expression_ns hsa-mir-19b Lung Neoplasms 30089594 "six microRNAs (miR-17, miR-190b, miR-19a, miR-19b, miR-26b, and miR-375) provided high diagnostic accuracy in discriminating lung cancer patients from healthy individuals" -tissue_expression_ns hsa-mir-26b Lung Neoplasms 30089594 "six microRNAs (miR-17, miR-190b, miR-19a, miR-19b, miR-26b, and miR-375) provided high diagnostic accuracy in discriminating lung cancer patients from healthy individuals" -tissue_expression_ns hsa-mir-375 Lung Neoplasms 30089594 "six microRNAs (miR-17, miR-190b, miR-19a, miR-19b, miR-26b, and miR-375) provided high diagnostic accuracy in discriminating lung cancer patients from healthy individuals" -tissue_expression_ns hsa-mir-141 Ovarian Neoplasms 30095616 MicroRNA-200 and microRNA-30 family as prognostic molecular signatures in ovarian cancer: A meta-analysis. -tissue_expression_ns hsa-mir-200a Ovarian Neoplasms 30095616 MicroRNA-200 and microRNA-30 family as prognostic molecular signatures in ovarian cancer: A meta-analysis. -tissue_expression_ns hsa-mir-200b Ovarian Neoplasms 30095616 MicroRNA-200 and microRNA-30 family as prognostic molecular signatures in ovarian cancer: A meta-analysis. -tissue_expression_ns hsa-mir-200c Ovarian Neoplasms 30095616 MicroRNA-200 and microRNA-30 family as prognostic molecular signatures in ovarian cancer: A meta-analysis. -tissue_expression_ns hsa-mir-30d Ovarian Neoplasms 30095616 MicroRNA-200 and microRNA-30 family as prognostic molecular signatures in ovarian cancer: A meta-analysis. -tissue_expression_ns hsa-mir-326 Gastric Neoplasms 30096452 Purified sulforaphane from broccoli (Brassica oleracea var. italica) leads to alterations of CDX1 and CDX2 expression and changes in miR-9 and miR-326 levels in human gastric cancer cells. -tissue_expression_ns hsa-mir-9 Gastric Neoplasms 30096452 Purified sulforaphane from broccoli (Brassica oleracea var. italica) leads to alterations of CDX1 and CDX2 expression and changes in miR-9 and miR-326 levels in human gastric cancer cells. -tissue_expression_ns hsa-mir-199b Parathyroid Carcinoma 30104706 Differential expression of miRNA199b-5p as a novel biomarker for sporadic and hereditary parathyroid tumors. -tissue_expression_ns hsa-mir-183 Renal Oncocytoma 30116406 "miR-498 (formation of the oncocytoma-specific slice-form of vimentin, Vim3), miR-183 (associated with increased CO2 levels), miR-205, and miR-31 (signaling through downregulation of PKC epsilon, shown previously)" -tissue_expression_ns hsa-mir-205 Renal Oncocytoma 30116406 "miR-498 (formation of the oncocytoma-specific slice-form of vimentin, Vim3), miR-183 (associated with increased CO2 levels), miR-205, and miR-31 (signaling through downregulation of PKC epsilon, shown previously)" -tissue_expression_ns hsa-mir-31 Renal Oncocytoma 30116406 "miR-498 (formation of the oncocytoma-specific slice-form of vimentin, Vim3), miR-183 (associated with increased CO2 levels), miR-205, and miR-31 (signaling through downregulation of PKC epsilon, shown previously)" -tissue_expression_ns hsa-mir-498 Renal Oncocytoma 30116406 "miR-498 (formation of the oncocytoma-specific slice-form of vimentin, Vim3), miR-183 (associated with increased CO2 levels), miR-205, and miR-31 (signaling through downregulation of PKC epsilon, shown previously)" -tissue_expression_ns hsa-let-7a-3 "Adenocarcinoma, Pancreatic Ductal" 30127641 "Eleven miRNAs (hsa-mir-501, hsa-mir-4521, hsa-mir-5091, hsa-mir-24-1, hsa-mir-126, hsa-mir-30e, hsa-mir-3157, hsa-let-7a-3, hsa-mir-133a-1, hsa-mir-4709, and hsa-mir-421) were used to construct a prognostic signature using the step function" -tissue_expression_ns hsa-mir-126 "Adenocarcinoma, Pancreatic Ductal" 30127641 "Eleven miRNAs (hsa-mir-501, hsa-mir-4521, hsa-mir-5091, hsa-mir-24-1, hsa-mir-126, hsa-mir-30e, hsa-mir-3157, hsa-let-7a-3, hsa-mir-133a-1, hsa-mir-4709, and hsa-mir-421) were used to construct a prognostic signature using the step function" -tissue_expression_ns hsa-mir-133a-1 "Adenocarcinoma, Pancreatic Ductal" 30127641 "Eleven miRNAs (hsa-mir-501, hsa-mir-4521, hsa-mir-5091, hsa-mir-24-1, hsa-mir-126, hsa-mir-30e, hsa-mir-3157, hsa-let-7a-3, hsa-mir-133a-1, hsa-mir-4709, and hsa-mir-421) were used to construct a prognostic signature using the step function" -tissue_expression_ns hsa-mir-24-1 "Adenocarcinoma, Pancreatic Ductal" 30127641 "Eleven miRNAs (hsa-mir-501, hsa-mir-4521, hsa-mir-5091, hsa-mir-24-1, hsa-mir-126, hsa-mir-30e, hsa-mir-3157, hsa-let-7a-3, hsa-mir-133a-1, hsa-mir-4709, and hsa-mir-421) were used to construct a prognostic signature using the step function" -tissue_expression_ns hsa-mir-30e "Adenocarcinoma, Pancreatic Ductal" 30127641 "Eleven miRNAs (hsa-mir-501, hsa-mir-4521, hsa-mir-5091, hsa-mir-24-1, hsa-mir-126, hsa-mir-30e, hsa-mir-3157, hsa-let-7a-3, hsa-mir-133a-1, hsa-mir-4709, and hsa-mir-421) were used to construct a prognostic signature using the step function" -tissue_expression_ns hsa-mir-3157 "Adenocarcinoma, Pancreatic Ductal" 30127641 "Eleven miRNAs (hsa-mir-501, hsa-mir-4521, hsa-mir-5091, hsa-mir-24-1, hsa-mir-126, hsa-mir-30e, hsa-mir-3157, hsa-let-7a-3, hsa-mir-133a-1, hsa-mir-4709, and hsa-mir-421) were used to construct a prognostic signature using the step function" -tissue_expression_ns hsa-mir-421 "Adenocarcinoma, Pancreatic Ductal" 30127641 "Eleven miRNAs (hsa-mir-501, hsa-mir-4521, hsa-mir-5091, hsa-mir-24-1, hsa-mir-126, hsa-mir-30e, hsa-mir-3157, hsa-let-7a-3, hsa-mir-133a-1, hsa-mir-4709, and hsa-mir-421) were used to construct a prognostic signature using the step function" -tissue_expression_ns hsa-mir-4521 "Adenocarcinoma, Pancreatic Ductal" 30127641 "Eleven miRNAs (hsa-mir-501, hsa-mir-4521, hsa-mir-5091, hsa-mir-24-1, hsa-mir-126, hsa-mir-30e, hsa-mir-3157, hsa-let-7a-3, hsa-mir-133a-1, hsa-mir-4709, and hsa-mir-421) were used to construct a prognostic signature using the step function" -tissue_expression_ns hsa-mir-4709 "Adenocarcinoma, Pancreatic Ductal" 30127641 "Eleven miRNAs (hsa-mir-501, hsa-mir-4521, hsa-mir-5091, hsa-mir-24-1, hsa-mir-126, hsa-mir-30e, hsa-mir-3157, hsa-let-7a-3, hsa-mir-133a-1, hsa-mir-4709, and hsa-mir-421) were used to construct a prognostic signature using the step function" -tissue_expression_ns hsa-mir-501 "Adenocarcinoma, Pancreatic Ductal" 30127641 "Eleven miRNAs (hsa-mir-501, hsa-mir-4521, hsa-mir-5091, hsa-mir-24-1, hsa-mir-126, hsa-mir-30e, hsa-mir-3157, hsa-let-7a-3, hsa-mir-133a-1, hsa-mir-4709, and hsa-mir-421) were used to construct a prognostic signature using the step function" -tissue_expression_ns hsa-mir-5091 "Adenocarcinoma, Pancreatic Ductal" 30127641 "Eleven miRNAs (hsa-mir-501, hsa-mir-4521, hsa-mir-5091, hsa-mir-24-1, hsa-mir-126, hsa-mir-30e, hsa-mir-3157, hsa-let-7a-3, hsa-mir-133a-1, hsa-mir-4709, and hsa-mir-421) were used to construct a prognostic signature using the step function" -tissue_expression_ns hsa-mir-203 Esophageal Neoplasms 30127973 Identification and verification of differentially expressed microRNAs and their target genes for the diagnosis of esophageal cancer. -tissue_expression_ns hsa-let-7b Smoke Inhalation Injury 30139538 Expression profile of microRNAs in bronchoalveolar lavage fluid of rats as predictors for smoke inhalation injury. -tissue_expression_ns hsa-let-7c Smoke Inhalation Injury 30139538 Expression profile of microRNAs in bronchoalveolar lavage fluid of rats as predictors for smoke inhalation injury. -tissue_expression_ns hsa-mir-205 Smoke Inhalation Injury 30139538 Expression profile of microRNAs in bronchoalveolar lavage fluid of rats as predictors for smoke inhalation injury. -tissue_expression_ns hsa-mir-34b Smoke Inhalation Injury 30139538 Expression profile of microRNAs in bronchoalveolar lavage fluid of rats as predictors for smoke inhalation injury. -tissue_expression_ns hsa-mir-34c Smoke Inhalation Injury 30139538 Expression profile of microRNAs in bronchoalveolar lavage fluid of rats as predictors for smoke inhalation injury. -tissue_expression_ns hsa-mir-92a Smoke Inhalation Injury 30139538 Expression profile of microRNAs in bronchoalveolar lavage fluid of rats as predictors for smoke inhalation injury. -tissue_expression_ns hsa-mir-92b Smoke Inhalation Injury 30139538 Expression profile of microRNAs in bronchoalveolar lavage fluid of rats as predictors for smoke inhalation injury. -tissue_expression_ns hsa-mir-1 Tetralogy Of Fallot 30150777 "miR-1/miR-133, which have been identified as essential for cardiac development, account for the most variance of sRNA expression between sexes in TOF hearts" -tissue_expression_ns hsa-mir-133b Tetralogy Of Fallot 30150777 "miR-1/miR-133, which have been identified as essential for cardiac development, account for the most variance of sRNA expression between sexes in TOF hearts" -tissue_expression_ns hsa-mir-125a "Carcinoma, Pancreatic" 30165365 "We identified that miR-23a, miR-30a, miR-125a, miR-129-1, miR-181b-1, miR-203, miR-221, miR-222, and miR-1301 had moderate diagnostic value for PaCa and predicted overall survival in PaCa patients" -tissue_expression_ns hsa-mir-129-1 "Carcinoma, Pancreatic" 30165365 "We identified that miR-23a, miR-30a, miR-125a, miR-129-1, miR-181b-1, miR-203, miR-221, miR-222, and miR-1301 had moderate diagnostic value for PaCa and predicted overall survival in PaCa patients" -tissue_expression_ns hsa-mir-1301 "Carcinoma, Pancreatic" 30165365 "We identified that miR-23a, miR-30a, miR-125a, miR-129-1, miR-181b-1, miR-203, miR-221, miR-222, and miR-1301 had moderate diagnostic value for PaCa and predicted overall survival in PaCa patients" -tissue_expression_ns hsa-mir-181b-1 "Carcinoma, Pancreatic" 30165365 "We identified that miR-23a, miR-30a, miR-125a, miR-129-1, miR-181b-1, miR-203, miR-221, miR-222, and miR-1301 had moderate diagnostic value for PaCa and predicted overall survival in PaCa patients" -tissue_expression_ns hsa-mir-203 "Carcinoma, Pancreatic" 30165365 "We identified that miR-23a, miR-30a, miR-125a, miR-129-1, miR-181b-1, miR-203, miR-221, miR-222, and miR-1301 had moderate diagnostic value for PaCa and predicted overall survival in PaCa patients" -tissue_expression_ns hsa-mir-221 "Carcinoma, Pancreatic" 30165365 "We identified that miR-23a, miR-30a, miR-125a, miR-129-1, miR-181b-1, miR-203, miR-221, miR-222, and miR-1301 had moderate diagnostic value for PaCa and predicted overall survival in PaCa patients" -tissue_expression_ns hsa-mir-222 "Carcinoma, Pancreatic" 30165365 "We identified that miR-23a, miR-30a, miR-125a, miR-129-1, miR-181b-1, miR-203, miR-221, miR-222, and miR-1301 had moderate diagnostic value for PaCa and predicted overall survival in PaCa patients" -tissue_expression_ns hsa-mir-23a "Carcinoma, Pancreatic" 30165365 "We identified that miR-23a, miR-30a, miR-125a, miR-129-1, miR-181b-1, miR-203, miR-221, miR-222, and miR-1301 had moderate diagnostic value for PaCa and predicted overall survival in PaCa patients" -tissue_expression_ns hsa-mir-30a "Carcinoma, Pancreatic" 30165365 "We identified that miR-23a, miR-30a, miR-125a, miR-129-1, miR-181b-1, miR-203, miR-221, miR-222, and miR-1301 had moderate diagnostic value for PaCa and predicted overall survival in PaCa patients" -tissue_expression_ns hsa-mir-181a Myeloma 30170425 The expression and role of miR-181a in multiple myeloma. -tissue_expression_ns hsa-let-7g "Carcinoma, Head And Neck" 30171046 "A five-miRNA-signature (hsa-let-7g-3p, hsa-miR-6508-5p, hsa-miR-210-5p, hsa-miR-4306 and hsa-miR-7161-3p) predicted freedom from recurrence in DKTK-ROG, which was confirmed in LMU-KKG" -tissue_expression_ns hsa-mir-210 "Carcinoma, Head And Neck" 30171046 "A five-miRNA-signature (hsa-let-7g-3p, hsa-miR-6508-5p, hsa-miR-210-5p, hsa-miR-4306 and hsa-miR-7161-3p) predicted freedom from recurrence in DKTK-ROG, which was confirmed in LMU-KKG" -tissue_expression_ns hsa-mir-4306 "Carcinoma, Head And Neck" 30171046 "A five-miRNA-signature (hsa-let-7g-3p, hsa-miR-6508-5p, hsa-miR-210-5p, hsa-miR-4306 and hsa-miR-7161-3p) predicted freedom from recurrence in DKTK-ROG, which was confirmed in LMU-KKG" -tissue_expression_ns hsa-mir-6508 "Carcinoma, Head And Neck" 30171046 "A five-miRNA-signature (hsa-let-7g-3p, hsa-miR-6508-5p, hsa-miR-210-5p, hsa-miR-4306 and hsa-miR-7161-3p) predicted freedom from recurrence in DKTK-ROG, which was confirmed in LMU-KKG" -tissue_expression_ns hsa-mir-7161 "Carcinoma, Head And Neck" 30171046 "A five-miRNA-signature (hsa-let-7g-3p, hsa-miR-6508-5p, hsa-miR-210-5p, hsa-miR-4306 and hsa-miR-7161-3p) predicted freedom from recurrence in DKTK-ROG, which was confirmed in LMU-KKG" -tissue_expression_ns hsa-mir-140 Multiple Sclerosis 30175165 "5 miRNAs (hsa-miR-484, hsa-miR-140-5p, hsa-miR-320a, hsa-miR-486-5p, and hsa-miR-320c) showed a significant difference between patients with MS and healthy individuals" -tissue_expression_ns hsa-mir-320a Multiple Sclerosis 30175165 "5 miRNAs (hsa-miR-484, hsa-miR-140-5p, hsa-miR-320a, hsa-miR-486-5p, and hsa-miR-320c) showed a significant difference between patients with MS and healthy individuals" -tissue_expression_ns hsa-mir-320c Multiple Sclerosis 30175165 "5 miRNAs (hsa-miR-484, hsa-miR-140-5p, hsa-miR-320a, hsa-miR-486-5p, and hsa-miR-320c) showed a significant difference between patients with MS and healthy individuals" -tissue_expression_ns hsa-mir-484 Multiple Sclerosis 30175165 "5 miRNAs (hsa-miR-484, hsa-miR-140-5p, hsa-miR-320a, hsa-miR-486-5p, and hsa-miR-320c) showed a significant difference between patients with MS and healthy individuals" -tissue_expression_ns hsa-mir-486 Multiple Sclerosis 30175165 "5 miRNAs (hsa-miR-484, hsa-miR-140-5p, hsa-miR-320a, hsa-miR-486-5p, and hsa-miR-320c) showed a significant difference between patients with MS and healthy individuals" -tissue_expression_ns hsa-mir-4511 "Carcinoma, Bladder" 30183088 "the proposed non-invasive diagnostic tool based on the expression ratio of urinary cell-free miR-6124 to miR-4511 can reduce unnecessary cystoscopies in patients with hematuria undergoing evaluation for BC, with a minimal loss in sensitivity for detecting cancer" -tissue_expression_ns hsa-mir-6124 "Carcinoma, Bladder" 30183088 "the proposed non-invasive diagnostic tool based on the expression ratio of urinary cell-free miR-6124 to miR-4511 can reduce unnecessary cystoscopies in patients with hematuria undergoing evaluation for BC, with a minimal loss in sensitivity for detecting cancer" -tissue_expression_ns hsa-mir-18a Neoplasms [unspecific] 30189225 Ribonucleic-acid-biomarker candidates for early-phase group detection of common cancers. -tissue_expression_ns hsa-mir-21 Neoplasms [unspecific] 30189225 Ribonucleic-acid-biomarker candidates for early-phase group detection of common cancers. -tissue_expression_ns hsa-mir-221 Neoplasms [unspecific] 30189225 Ribonucleic-acid-biomarker candidates for early-phase group detection of common cancers. -tissue_expression_ns hsa-mir-375 Neoplasms [unspecific] 30189225 Ribonucleic-acid-biomarker candidates for early-phase group detection of common cancers. -tissue_expression_ns hsa-mir-1290 "Carcinoma, Lung, Non-Small-Cell" 30190521 "combination of miR-1290, miR-196b and miR-135a in tumor tissue, and miR-21, miR-25, miR27b, and miR-326 in plasma were predictive for response to platinum-based chemotherapy in advanced NSCLC" -tissue_expression_ns hsa-mir-135a "Carcinoma, Lung, Non-Small-Cell" 30190521 "combination of miR-1290, miR-196b and miR-135a in tumor tissue, and miR-21, miR-25, miR27b, and miR-326 in plasma were predictive for response to platinum-based chemotherapy in advanced NSCLC" -tissue_expression_ns hsa-mir-196b "Carcinoma, Lung, Non-Small-Cell" 30190521 "combination of miR-1290, miR-196b and miR-135a in tumor tissue, and miR-21, miR-25, miR27b, and miR-326 in plasma were predictive for response to platinum-based chemotherapy in advanced NSCLC" -tissue_expression_ns hsa-mir-10a "Carcinoma, Cervical" 30191988 "The upregulation of some circulating miRNAs, for example, miRNA-20a, miRNA-203, miRNA-21, miRNA-205, miRNA-218, and miR-485-5, as well as tissue-specific miRNAs, for example, miR-7, miR-10a, miR-17-5p, miR-135b, miR-149, and miR-203 have been found in patients with CC" -tissue_expression_ns hsa-mir-135b "Carcinoma, Cervical" 30191988 "The upregulation of some circulating miRNAs, for example, miRNA-20a, miRNA-203, miRNA-21, miRNA-205, miRNA-218, and miR-485-5, as well as tissue-specific miRNAs, for example, miR-7, miR-10a, miR-17-5p, miR-135b, miR-149, and miR-203 have been found in patients with CC" -tissue_expression_ns hsa-mir-149 "Carcinoma, Cervical" 30191988 "The upregulation of some circulating miRNAs, for example, miRNA-20a, miRNA-203, miRNA-21, miRNA-205, miRNA-218, and miR-485-5, as well as tissue-specific miRNAs, for example, miR-7, miR-10a, miR-17-5p, miR-135b, miR-149, and miR-203 have been found in patients with CC" -tissue_expression_ns hsa-mir-17 "Carcinoma, Cervical" 30191988 "The upregulation of some circulating miRNAs, for example, miRNA-20a, miRNA-203, miRNA-21, miRNA-205, miRNA-218, and miR-485-5, as well as tissue-specific miRNAs, for example, miR-7, miR-10a, miR-17-5p, miR-135b, miR-149, and miR-203 have been found in patients with CC" -tissue_expression_ns hsa-mir-203 "Carcinoma, Cervical" 30191988 "The upregulation of some circulating miRNAs, for example, miRNA-20a, miRNA-203, miRNA-21, miRNA-205, miRNA-218, and miR-485-5, as well as tissue-specific miRNAs, for example, miR-7, miR-10a, miR-17-5p, miR-135b, miR-149, and miR-203 have been found in patients with CC" -tissue_expression_ns hsa-mir-7 "Carcinoma, Cervical" 30191988 "The upregulation of some circulating miRNAs, for example, miRNA-20a, miRNA-203, miRNA-21, miRNA-205, miRNA-218, and miR-485-5, as well as tissue-specific miRNAs, for example, miR-7, miR-10a, miR-17-5p, miR-135b, miR-149, and miR-203 have been found in patients with CC" -tissue_expression_ns hsa-mir-141 "Carcinoma, Bladder" 30194772 "miR-21-5p, miR-141-3p, and miR-205-5p levels in urine-promising biomarkers for the identification of prostate and bladder cancer." -tissue_expression_ns hsa-mir-141 Prostate Neoplasms 30194772 "miR-21-5p, miR-141-3p, and miR-205-5p levels in urine-promising biomarkers for the identification of prostate and bladder cancer." -tissue_expression_ns hsa-mir-205 "Carcinoma, Bladder" 30194772 "miR-21-5p, miR-141-3p, and miR-205-5p levels in urine-promising biomarkers for the identification of prostate and bladder cancer." -tissue_expression_ns hsa-mir-205 Prostate Neoplasms 30194772 "miR-21-5p, miR-141-3p, and miR-205-5p levels in urine-promising biomarkers for the identification of prostate and bladder cancer." -tissue_expression_ns hsa-mir-21 "Carcinoma, Bladder" 30194772 "miR-21-5p, miR-141-3p, and miR-205-5p levels in urine-promising biomarkers for the identification of prostate and bladder cancer." -tissue_expression_ns hsa-mir-21 Prostate Neoplasms 30194772 "miR-21-5p, miR-141-3p, and miR-205-5p levels in urine-promising biomarkers for the identification of prostate and bladder cancer." -tissue_expression_ns hsa-mir-301a Prostate Neoplasms 30195463 miR-301a expression: Diagnostic and prognostic marker for prostate cancer. -tissue_expression_ns hsa-mir-200b Glioma 30197535 MicroRNA-200b expression level is negatively associated with pathological grading in human gliomas. -tissue_expression_ns hsa-mir-206 "Colitis, Ulcerative" 30204869 miR-206 as a Biomarker for Response to Mesalamine Treatment in Ulcerative Colitis. -tissue_expression_ns hsa-mir-1246 Gastrointestinal Neoplasms 30235938 Exosomal miR-1246 in body fluids is a potential biomarker for gastrointestinal cancer. -tissue_expression_ns hsa-mir-320a Cardiac Myxoma 30250535 Specific miRNA expression profile in the blood serum of cardiac myxoma patients. -tissue_expression_ns hsa-mir-634 Cardiac Myxoma 30250535 Specific miRNA expression profile in the blood serum of cardiac myxoma patients. -tissue_expression_ns hsa-mir-1260a Prostate Neoplasms 30250996 Expression patterns and bioinformatic analysis of miR-1260a and miR-1274a in Prostate Cancer Tunisian patients. -tissue_expression_ns hsa-mir-1274a Prostate Neoplasms 30250996 Expression patterns and bioinformatic analysis of miR-1260a and miR-1274a in Prostate Cancer Tunisian patients. -tissue_expression_ns hsa-mir-125b "Carcinoma, Lung, Non-Small-Cell" 30254489 Establishment and validation of a 7-microRNA prognostic signature for non-small cell lung cancer. -tissue_expression_ns hsa-mir-148b "Carcinoma, Lung, Non-Small-Cell" 30254489 Establishment and validation of a 7-microRNA prognostic signature for non-small cell lung cancer. -tissue_expression_ns hsa-mir-155 "Carcinoma, Lung, Non-Small-Cell" 30254489 Establishment and validation of a 7-microRNA prognostic signature for non-small cell lung cancer. -tissue_expression_ns hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 30254489 Establishment and validation of a 7-microRNA prognostic signature for non-small cell lung cancer. -tissue_expression_ns hsa-mir-32 "Carcinoma, Lung, Non-Small-Cell" 30254489 Establishment and validation of a 7-microRNA prognostic signature for non-small cell lung cancer. -tissue_expression_ns hsa-mir-365 "Carcinoma, Lung, Non-Small-Cell" 30254489 Establishment and validation of a 7-microRNA prognostic signature for non-small cell lung cancer. -tissue_expression_ns hsa-mir-375 "Carcinoma, Lung, Non-Small-Cell" 30254489 Establishment and validation of a 7-microRNA prognostic signature for non-small cell lung cancer. -tissue_expression_ns hsa-mir-196a Pancreatic Adenocarcinoma 30258849 Evaluation of Plasma MicroRNAs as Diagnostic and Prognostic Biomarkers in Pancreatic Adenocarcinoma: miR-196a and miR-210 Could Be Negative and Positive Prognostic Markers -tissue_expression_ns hsa-mir-210 Pancreatic Adenocarcinoma 30258849 Evaluation of Plasma MicroRNAs as Diagnostic and Prognostic Biomarkers in Pancreatic Adenocarcinoma: miR-196a and miR-210 Could Be Negative and Positive Prognostic Markers -tissue_expression_ns hsa-mir-21 Stroke 30267810 MiR-21 was found to be normally up and down regulated in all types of strokes -tissue_expression_ns hsa-mir-138 "Adenocarcinoma, Lung" 30271594 Expression profiling and microRNA regulation of the LKB1 pathway in young and aged lung adenocarcinoma patients. -tissue_expression_ns hsa-mir-145 "Adenocarcinoma, Lung" 30271594 Expression profiling and microRNA regulation of the LKB1 pathway in young and aged lung adenocarcinoma patients. -tissue_expression_ns hsa-mir-153 "Adenocarcinoma, Lung" 30271594 Expression profiling and microRNA regulation of the LKB1 pathway in young and aged lung adenocarcinoma patients. -tissue_expression_ns hsa-mir-182 "Adenocarcinoma, Lung" 30271594 Expression profiling and microRNA regulation of the LKB1 pathway in young and aged lung adenocarcinoma patients. -tissue_expression_ns hsa-mir-183 "Adenocarcinoma, Lung" 30271594 Expression profiling and microRNA regulation of the LKB1 pathway in young and aged lung adenocarcinoma patients. -tissue_expression_ns hsa-mir-214 "Adenocarcinoma, Lung" 30271594 Expression profiling and microRNA regulation of the LKB1 pathway in young and aged lung adenocarcinoma patients. -tissue_expression_ns hsa-mir-214 "Adenocarcinoma, Lung" 30271594 Expression profiling and microRNA regulation of the LKB1 pathway in young and aged lung adenocarcinoma patients. -tissue_expression_ns hsa-mir-29b "Adenocarcinoma, Lung" 30271594 Expression profiling and microRNA regulation of the LKB1 pathway in young and aged lung adenocarcinoma patients. -tissue_expression_ns hsa-mir-29c "Adenocarcinoma, Lung" 30271594 Expression profiling and microRNA regulation of the LKB1 pathway in young and aged lung adenocarcinoma patients. -tissue_expression_ns hsa-mir-30b "Adenocarcinoma, Lung" 30271594 Expression profiling and microRNA regulation of the LKB1 pathway in young and aged lung adenocarcinoma patients. -tissue_expression_ns hsa-mir-30c "Adenocarcinoma, Lung" 30271594 Expression profiling and microRNA regulation of the LKB1 pathway in young and aged lung adenocarcinoma patients. -tissue_expression_ns hsa-mir-33a "Adenocarcinoma, Lung" 30271594 Expression profiling and microRNA regulation of the LKB1 pathway in young and aged lung adenocarcinoma patients. -tissue_expression_ns hsa-mir-34a "Adenocarcinoma, Lung" 30271594 Expression profiling and microRNA regulation of the LKB1 pathway in young and aged lung adenocarcinoma patients. -tissue_expression_ns hsa-mir-34a "Adenocarcinoma, Lung" 30271594 Expression profiling and microRNA regulation of the LKB1 pathway in young and aged lung adenocarcinoma patients. -tissue_expression_ns hsa-mir-34c "Adenocarcinoma, Lung" 30271594 Expression profiling and microRNA regulation of the LKB1 pathway in young and aged lung adenocarcinoma patients. -tissue_expression_ns hsa-mir-34c "Adenocarcinoma, Lung" 30271594 Expression profiling and microRNA regulation of the LKB1 pathway in young and aged lung adenocarcinoma patients. -tissue_expression_ns hsa-mir-93 "Adenocarcinoma, Lung" 30271594 Expression profiling and microRNA regulation of the LKB1 pathway in young and aged lung adenocarcinoma patients. -tissue_expression_ns hsa-mir-96 "Adenocarcinoma, Lung" 30271594 Expression profiling and microRNA regulation of the LKB1 pathway in young and aged lung adenocarcinoma patients. -tissue_expression_ns hsa-mir-17 Gastrointestinal Neoplasms 30275704 Prognostic value of miR-17-5p in gastrointestinal cancers: a systematic review and meta-analysis. -tissue_expression_ns hsa-mir-139 "Carcinoma, Hepatocellular" 30290990 Low microRNA-139 expression associates with poor prognosis in patients with tumors: A meta-analysis. -tissue_expression_ns hsa-mir-106b Pancreatic Endocrine Carcinoma 30299890 "The expression of hsa-miR-106b, hsa-miR-10a and especially hsa-miR-21 has prognostic relevance regarding progression-free and overall survival in patients with PanNENs" -tissue_expression_ns hsa-mir-10a Pancreatic Endocrine Carcinoma 30299890 "The expression of hsa-miR-106b, hsa-miR-10a and especially hsa-miR-21 has prognostic relevance regarding progression-free and overall survival in patients with PanNENs" -tissue_expression_ns hsa-mir-21 Pancreatic Endocrine Carcinoma 30299890 "The expression of hsa-miR-106b, hsa-miR-10a and especially hsa-miR-21 has prognostic relevance regarding progression-free and overall survival in patients with PanNENs" -tissue_expression_ns hsa-mir-182 "Carcinoma, Bladder" 30304549 Comprehensive analysis of microRNA-messenger RNA regulatory network in gemcitabine-resistant bladder cancer cells. -tissue_expression_ns hsa-mir-320a "Carcinoma, Bladder" 30304549 Comprehensive analysis of microRNA-messenger RNA regulatory network in gemcitabine-resistant bladder cancer cells. -tissue_expression_ns hsa-mir-550a "Carcinoma, Bladder" 30304549 Comprehensive analysis of microRNA-messenger RNA regulatory network in gemcitabine-resistant bladder cancer cells. -tissue_expression_ns hsa-mir-10a "Carcinoma, Urothelial, Upper Tract" 30315887 "OS was best predicted by miR-10a-5p, miR-199a-5p, miR-30c-5p, and miR-10b-5p" -tissue_expression_ns hsa-mir-10b "Carcinoma, Urothelial, Upper Tract" 30315887 "OS was best predicted by miR-10a-5p, miR-199a-5p, miR-30c-5p, and miR-10b-5p" -tissue_expression_ns hsa-mir-199a "Carcinoma, Urothelial, Upper Tract" 30315887 "OS was best predicted by miR-10a-5p, miR-199a-5p, miR-30c-5p, and miR-10b-5p" -tissue_expression_ns hsa-mir-30c "Carcinoma, Urothelial, Upper Tract" 30315887 "OS was best predicted by miR-10a-5p, miR-199a-5p, miR-30c-5p, and miR-10b-5p" -tissue_expression_ns hsa-let-7c "Carcinoma, Bladder" 30322728 " we identified a subset of 6 miRs (let-7c, miR-135a, miR-135b, miR-148a, miR-204, miR-345) that distinguished BC from controls with an area under the curve of 88.3%" -tissue_expression_ns hsa-mir-135a "Carcinoma, Bladder" 30322728 " we identified a subset of 6 miRs (let-7c, miR-135a, miR-135b, miR-148a, miR-204, miR-345) that distinguished BC from controls with an area under the curve of 88.3%" -tissue_expression_ns hsa-mir-135b "Carcinoma, Bladder" 30322728 " we identified a subset of 6 miRs (let-7c, miR-135a, miR-135b, miR-148a, miR-204, miR-345) that distinguished BC from controls with an area under the curve of 88.3%" -tissue_expression_ns hsa-mir-148a "Carcinoma, Bladder" 30322728 " we identified a subset of 6 miRs (let-7c, miR-135a, miR-135b, miR-148a, miR-204, miR-345) that distinguished BC from controls with an area under the curve of 88.3%" -tissue_expression_ns hsa-mir-204 "Carcinoma, Bladder" 30322728 " we identified a subset of 6 miRs (let-7c, miR-135a, miR-135b, miR-148a, miR-204, miR-345) that distinguished BC from controls with an area under the curve of 88.3%" -tissue_expression_ns hsa-mir-345 "Carcinoma, Bladder" 30322728 " we identified a subset of 6 miRs (let-7c, miR-135a, miR-135b, miR-148a, miR-204, miR-345) that distinguished BC from controls with an area under the curve of 88.3%" -tissue_expression_ns hsa-mir-141 Prostate Neoplasms 30334974 "PCA3, hK2, and miRNA-141 were biomarkers of Pca with potential clinical application value, especially in patients with PSA gray area" -tissue_expression_ns hsa-mir-296 "Squamous Cell Carcinoma, Lung" 30337605 "miR-296-5p, miR-324-3p, and miR-3928-3p expression was significantly associated with poor prognosis" -tissue_expression_ns hsa-mir-324 "Squamous Cell Carcinoma, Lung" 30337605 "miR-296-5p, miR-324-3p, and miR-3928-3p expression was significantly associated with poor prognosis" -tissue_expression_ns hsa-mir-3928 "Squamous Cell Carcinoma, Lung" 30337605 "miR-296-5p, miR-324-3p, and miR-3928-3p expression was significantly associated with poor prognosis" -tissue_expression_ns hsa-mir-424 Prostate Neoplasms 30345533 differential expression of miR-424 and miR-572 in recurrent PCa specimens can serve as novel biomarkers for prediction of Pca progression -tissue_expression_ns hsa-mir-572 Prostate Neoplasms 30345533 differential expression of miR-424 and miR-572 in recurrent PCa specimens can serve as novel biomarkers for prediction of Pca progression -tissue_expression_ns hsa-mir-106a "Cardiomyopathy, Dilated" 30346833 miR-15b-5p and miR-106a-5p expression levels could potentially serve as useful biomarkers for distinguishing between IsDC and IdDC -tissue_expression_ns hsa-mir-15b "Cardiomyopathy, Dilated" 30346833 miR-15b-5p and miR-106a-5p expression levels could potentially serve as useful biomarkers for distinguishing between IsDC and IdDC -tissue_expression_ns hsa-mir-155 Colorectal Carcinoma 30348685 "Expression of Circulating miR-155, miR-21, miR-221, miR-30a, miR-34a and miR-29a: Comparison of Colonic and Rectal Cancer." -tissue_expression_ns hsa-mir-21 Colorectal Carcinoma 30348685 "Expression of Circulating miR-155, miR-21, miR-221, miR-30a, miR-34a and miR-29a: Comparison of Colonic and Rectal Cancer." -tissue_expression_ns hsa-mir-221 Colorectal Carcinoma 30348685 "Expression of Circulating miR-155, miR-21, miR-221, miR-30a, miR-34a and miR-29a: Comparison of Colonic and Rectal Cancer." -tissue_expression_ns hsa-mir-29a Colorectal Carcinoma 30348685 "Expression of Circulating miR-155, miR-21, miR-221, miR-30a, miR-34a and miR-29a: Comparison of Colonic and Rectal Cancer." -tissue_expression_ns hsa-mir-30a Colorectal Carcinoma 30348685 "Expression of Circulating miR-155, miR-21, miR-221, miR-30a, miR-34a and miR-29a: Comparison of Colonic and Rectal Cancer." -tissue_expression_ns hsa-mir-34a Colorectal Carcinoma 30348685 "Expression of Circulating miR-155, miR-21, miR-221, miR-30a, miR-34a and miR-29a: Comparison of Colonic and Rectal Cancer." -tissue_expression_ns hsa-mir-1246 "Carcinoma, Breast" 30350935 In Situ Detection of Plasma Exosomal MicroRNA-1246 for Breast Cancer Diagnostics by a Au Nanoflare Probe. -tissue_expression_ns hsa-mir-4507 Prader-Willi Syndrome 30352401 "A different signature of miRNAs significantly distinguished PWS with steatosis from PWS without steatosis, involving miR-619-5p, miR-4507, miR-4656, miR-7847-3p and miR-6782-5p" -tissue_expression_ns hsa-mir-4656 Prader-Willi Syndrome 30352401 "A different signature of miRNAs significantly distinguished PWS with steatosis from PWS without steatosis, involving miR-619-5p, miR-4507, miR-4656, miR-7847-3p and miR-6782-5p" -tissue_expression_ns hsa-mir-619 Prader-Willi Syndrome 30352401 "A different signature of miRNAs significantly distinguished PWS with steatosis from PWS without steatosis, involving miR-619-5p, miR-4507, miR-4656, miR-7847-3p and miR-6782-5p" -tissue_expression_ns hsa-mir-6782 Prader-Willi Syndrome 30352401 "A different signature of miRNAs significantly distinguished PWS with steatosis from PWS without steatosis, involving miR-619-5p, miR-4507, miR-4656, miR-7847-3p and miR-6782-5p" -tissue_expression_ns hsa-mir-7847 Prader-Willi Syndrome 30352401 "A different signature of miRNAs significantly distinguished PWS with steatosis from PWS without steatosis, involving miR-619-5p, miR-4507, miR-4656, miR-7847-3p and miR-6782-5p" -tissue_expression_ns hsa-mir-1283 Endometriosis 30359864 "the treatment of quercetin induced miR-503-5p, miR-1283, miR-3714 and miR-6867-5p related to CCND1 in both cell lines and also stimulated miR-503-5p and miR-546 expression in the mouse model" -tissue_expression_ns hsa-mir-3714 Endometriosis 30359864 "the treatment of quercetin induced miR-503-5p, miR-1283, miR-3714 and miR-6867-5p related to CCND1 in both cell lines and also stimulated miR-503-5p and miR-546 expression in the mouse model" -tissue_expression_ns hsa-mir-503 Endometriosis 30359864 "the treatment of quercetin induced miR-503-5p, miR-1283, miR-3714 and miR-6867-5p related to CCND1 in both cell lines and also stimulated miR-503-5p and miR-546 expression in the mouse model" -tissue_expression_ns hsa-mir-503 Endometriosis 30359864 "the treatment of quercetin induced miR-503-5p, miR-1283, miR-3714 and miR-6867-5p related to CCND1 in both cell lines and also stimulated miR-503-5p and miR-546 expression in the mouse model" -tissue_expression_ns hsa-mir-6867 Endometriosis 30359864 "the treatment of quercetin induced miR-503-5p, miR-1283, miR-3714 and miR-6867-5p related to CCND1 in both cell lines and also stimulated miR-503-5p and miR-546 expression in the mouse model" -tissue_expression_ns hsa-mir-21 X-linked Alport Syndrome 30370838 Abnormal Expression of miR-21 in Kidney Tissue of Dogs With X-Linked Hereditary Nephropathy: A Canine Model of Chronic Kidney Disease. -tissue_expression_ns hsa-mir-1307 "Carcinoma, Breast" 30382159 "four miRNAs, hsa-miR-503, hsa-miR-1307, hsa-miR-212 and hsa-miR-592, were significantly associated with the prognosis of patients with breast cancer" -tissue_expression_ns hsa-mir-212 "Carcinoma, Breast" 30382159 "four miRNAs, hsa-miR-503, hsa-miR-1307, hsa-miR-212 and hsa-miR-592, were significantly associated with the prognosis of patients with breast cancer" -tissue_expression_ns hsa-mir-503 "Carcinoma, Breast" 30382159 "four miRNAs, hsa-miR-503, hsa-miR-1307, hsa-miR-212 and hsa-miR-592, were significantly associated with the prognosis of patients with breast cancer" -tissue_expression_ns hsa-mir-592 "Carcinoma, Breast" 30382159 "four miRNAs, hsa-miR-503, hsa-miR-1307, hsa-miR-212 and hsa-miR-592, were significantly associated with the prognosis of patients with breast cancer" -tissue_expression_up hsa-mir-155 "Lymphoma, Hodgkin" 12661002 upregulated -tissue_expression_up hsa-mir-17 "Leukemia, B-Cell" 15944707 overexpression -tissue_expression_up hsa-mir-17 "Lymphoma, B-Cell" 15944707 overexpressed -tissue_expression_up hsa-mir-18a "Leukemia, B-Cell" 15944707 overexpression -tissue_expression_up hsa-mir-18a "Lymphoma, B-Cell" 15944707 overexpressed -tissue_expression_up hsa-mir-19a "Leukemia, B-Cell" 15944707 overexpression -tissue_expression_up hsa-mir-19a "Lymphoma, B-Cell" 15944707 overexpressed -tissue_expression_up hsa-mir-19b-1 "Leukemia, B-Cell" 15944707 overexpression -tissue_expression_up hsa-mir-19b-1 "Lymphoma, B-Cell" 15944707 overexpressed -tissue_expression_up hsa-mir-19b-2 "Lymphoma, B-Cell" 15944707 overexpressed -tissue_expression_up hsa-mir-20a "Leukemia, B-Cell" 15944707 overexpression -tissue_expression_up hsa-mir-92a-1 "Leukemia, B-Cell" 15944707 overexpression -tissue_expression_up hsa-mir-21 Glioblastoma 16024602 upregulated -tissue_expression_up hsa-mir-21 Glioblastoma 16039986 upregulated -tissue_expression_up hsa-mir-155 "Lymphoma, Large B-Cell, Diffuse" 16041695 upregulated -tissue_expression_up hsa-mir-155 Breast Neoplasms 16103053 upregulated -tissue_expression_up hsa-mir-21 Breast Neoplasms 16103053 upregulation -tissue_expression_up hsa-mir-15b Hepatitis C Virus Infection 16331254 overexpression -tissue_expression_up hsa-mir-182 Hepatitis C Virus Infection 16331254 overexpression -tissue_expression_up hsa-mir-18a "Carcinoma, Hepatocellular" 16331254 upregulated -tissue_expression_up hsa-mir-18b "Carcinoma, Hepatocellular" 16331254 upregulated -tissue_expression_up hsa-mir-199b Hepatitis C Virus Infection 16331254 overexpression -tissue_expression_up hsa-mir-20a "Carcinoma, Hepatocellular" 16331254 overexpression -tissue_expression_up hsa-mir-20b "Carcinoma, Hepatocellular" 16331254 overexpression -tissue_expression_up hsa-mir-224 "Carcinoma, Hepatocellular" 16331254 upregulated -tissue_expression_up hsa-mir-224 Hepatitis C Virus Infection 16331254 overexpression -tissue_expression_up hsa-mir-92a-1 "Carcinoma, Hepatocellular" 16331254 overexpression -tissue_expression_up hsa-mir-92a-2 "Carcinoma, Hepatocellular" 16331254 overexpression -tissue_expression_up hsa-mir-92b "Carcinoma, Hepatocellular" 16331254 overexpression -tissue_expression_up hsa-mir-221 "Carcinoma, Thyroid, Papillary" 16365291 upregulation -tissue_expression_up hsa-mir-106a Colon Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-106a Pancreatic Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-106a Prostate Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-107 Colon Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-107 Gastric Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-107 Pancreatic Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-128-2 Colon Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-128-2 Lung Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-128-2 Pancreatic Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-146a Breast Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-146a Pancreatic Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-146a Prostate Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-146b Breast Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-146b Pancreatic Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-146b Prostate Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-155 Breast Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-155 Colon Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-155 Lung Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-17 Breast Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-17 Colon Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-17 Lung Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-17 Pancreatic Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-17 Prostate Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-181b-1 Breast Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-181b-1 Pancreatic Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-181b-1 Prostate Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-191 Colon Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-191 Gastric Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-191 Lung Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-191 Pancreatic Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-191 Prostate Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-199a-1 Lung Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-199a-1 Pancreatic Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-199a-1 Prostate Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-20a Colon Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-20a Pancreatic Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-20a Prostate Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-21 Breast Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-21 Colon Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-21 Gastric Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-21 Lung Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-21 Pancreatic Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-21 Prostate Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-214 Gastric Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-214 Pancreatic Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-214 Prostate Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-221 Colon Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-221 Gastric Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-221 Pancreatic Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-223 Colon Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-223 Gastric Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-223 Pancreatic Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-223 Prostate Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-24-1 Colon Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-24-1 Gastric Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-24-1 Pancreatic Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-24-2 Colon Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-24-2 Gastric Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-24-2 Pancreatic Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-25 Gastric Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-25 Pancreatic Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-25 Prostate Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-29b-1 Breast Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-29b-1 Colon Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-29b-1 Pancreatic Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-29b-1 Prostate Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-30c-1 Colon Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-30c-1 Pancreatic Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-30c-1 Prostate Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-30c-2 Colon Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-30c-2 Pancreatic Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-30c-2 Prostate Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-32 Colon Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-32 Pancreatic Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-32 Prostate Neoplasms 16461460 overexpressed -tissue_expression_up hsa-mir-106a Lung Neoplasms 16530703 upregulation -tissue_expression_up hsa-mir-146a Lung Neoplasms 16530703 upregulation -tissue_expression_up hsa-mir-146b Lung Neoplasms 16530703 upregulation -tissue_expression_up hsa-mir-150 Lung Neoplasms 16530703 upregulation -tissue_expression_up hsa-mir-155 Lung Neoplasms 16530703 upregulation -tissue_expression_up hsa-mir-17 Lung Neoplasms 16530703 upregulation -tissue_expression_up hsa-mir-191 Lung Neoplasms 16530703 upregulation -tissue_expression_up hsa-mir-197 Lung Neoplasms 16530703 upregulation -tissue_expression_up hsa-mir-203 Lung Neoplasms 16530703 upregulation -tissue_expression_up hsa-mir-205 Lung Neoplasms 16530703 upregulation -tissue_expression_up hsa-mir-21 Lung Neoplasms 16530703 upregulation -tissue_expression_up hsa-mir-210 Lung Neoplasms 16530703 upregulation -tissue_expression_up hsa-mir-212 Lung Neoplasms 16530703 upregulation -tissue_expression_up hsa-mir-214 Lung Neoplasms 16530703 upregulation -tissue_expression_up hsa-mir-24-2 Lung Neoplasms 16530703 upregulation -tissue_expression_up hsa-mir-221 "Carcinoma, Thyroid, Papillary" 16728577 upregulation -tissue_expression_up hsa-mir-222 "Carcinoma, Thyroid, Papillary" 16728577 upregulation -tissue_expression_up hsa-mir-141 Cholangiocarcinoma 16762633 "MiR-21, miR-141, and miR-200b were highly over-expressed in malignant cholangiocytes." -tissue_expression_up hsa-mir-200b Cholangiocarcinoma 16762633 "MiR-21, miR-141, and miR-200b were highly over-expressed in malignant cholangiocytes." -tissue_expression_up hsa-mir-21 Cholangiocarcinoma 16762633 "MiR-21, miR-141, and miR-200b were highly over-expressed in malignant cholangiocytes." -tissue_expression_up hsa-mir-183 Lung Neoplasms 17028596 "mir-124, mir-183, mir-223, mir-29 mir-124a-3 downregulated in lung cancer (Yanaihara et al., 2006);" -tissue_expression_up hsa-mir-206 Breast Neoplasms 17028596 "mir-206 upregulated in breast cancer (Iorio et al., 2005)." -tissue_expression_up hsa-mir-21 Neoplasms [unspecific] 17028596 "mir-21 upregulated in glioblastoma and associated with antiapoptosis upregulated in breast cancer (Iorio et al., 2005), and in a signature for solid cancers (Volinia et al., 2006)." -tissue_expression_up hsa-mir-221 Thyroid Neoplasms 17028596 Upregulated mir-221/222 in papillary thyroid cancer -tissue_expression_up hsa-mir-222 Thyroid Neoplasms 17028596 Upregulated mir-221/222 in papillary thyroid cancer -tissue_expression_up hsa-mir-9-1 Breast Neoplasms 17028596 "mir-9 increased in breast cancers (Iorio et al., 2005), but downregulated in lung cancers (Yanaihara et al., 2006)" -tissue_expression_up hsa-mir-9-2 Breast Neoplasms 17028596 "mir-9 increased in breast cancers (Iorio et al., 2005), but downregulated in lung cancers (Yanaihara et al., 2006)" -tissue_expression_up hsa-mir-9-3 Breast Neoplasms 17028596 "mir-9 increased in breast cancers (Iorio et al., 2005), but downregulated in lung cancers (Yanaihara et al., 2006)" -tissue_expression_up hsa-mir-195 "Cardiomyopathy, Hypertrophic" 17108080 "miR-23a, miR-23b, miR-24, miR-195, and miR-214, all of which were up-regulated during cardiac hypertrophy, appeared to be capable of inducing hypertrophic growth in vitro." -tissue_expression_up hsa-mir-195 Heart Failure 17108080 overexpressed -tissue_expression_up hsa-mir-199a-1 "Cardiomyopathy, Hypertrophic" 17108080 overexpressed -tissue_expression_up hsa-mir-199a-2 "Cardiomyopathy, Hypertrophic" 17108080 overexpressed -tissue_expression_up hsa-mir-214 "Cardiomyopathy, Hypertrophic" 17108080 overexpressed -tissue_expression_up hsa-mir-23a "Cardiomyopathy, Hypertrophic" 17108080 "miR-23a, miR-23b, miR-24, miR-195, and miR-214, all of which were up-regulated during cardiac hypertrophy, appeared to be capable of inducing hypertrophic growth in vitro." -tissue_expression_up hsa-mir-23b "Cardiomyopathy, Hypertrophic" 17108080 "miR-23a, miR-23b, miR-24, miR-195, and miR-214, all of which were up-regulated during cardiac hypertrophy, appeared to be capable of inducing hypertrophic growth in vitro." -tissue_expression_up hsa-mir-24-1 "Cardiomyopathy, Hypertrophic" 17108080 "miR-23a, miR-23b, miR-24, miR-195, and miR-214, all of which were up-regulated during cardiac hypertrophy, appeared to be capable of inducing hypertrophic growth in vitro." -tissue_expression_up hsa-mir-24-2 "Cardiomyopathy, Hypertrophic" 17108080 "miR-23a, miR-23b, miR-24, miR-195, and miR-214, all of which were up-regulated during cardiac hypertrophy, appeared to be capable of inducing hypertrophic growth in vitro." -tissue_expression_up hsa-mir-106b Schizophrenia 17326821 upregulation -tissue_expression_up hsa-mir-1-1 Coronary Artery Disease 17401374 overexpressed -tissue_expression_up hsa-mir-1-2 Coronary Artery Disease 17401374 overexpressed -tissue_expression_up hsa-mir-196a-2 Pancreatic Neoplasms 17473300 "Finally, high expression of miR-196a-2 was found to predict poor survival (median, 14.3 months [95% confidence interval, 12.4-16.2] vs 26.5 months [95% confidence interval, 23.4-29.6]; P = .009)." -tissue_expression_up hsa-mir-21 Breast Neoplasms 17531469 "MiR-21 is found to be highly expressed in numerous cancers like breast cancer, and glioblastoma and pancreatic cancer." -tissue_expression_up hsa-mir-21 Cholangiocarcinoma 17531469 "Recently Meng et al. showed that miR-21 is also overexpressed in malignant cholangiocarcinomas, a highly chemoresistant cancer type, knockdown of miR-21 sensitised cholangiocarcinoma cell lines for treatment with gemcitabin, whereas transfection of non-malignant cholangiocytes with precursor miR-21 made cells more resistant to gemcitabin." -tissue_expression_up hsa-mir-21 Glioblastoma 17531469 "MiR-21 is found to be highly expressed in numerous cancers like breast cancer, and glioblastoma and pancreatic cancer." -tissue_expression_up hsa-mir-21 Pancreatic Neoplasms 17531469 "MiR-21 is found to be highly expressed in numerous cancers like breast cancer, and glioblastoma and pancreatic cancer." -tissue_expression_up hsa-mir-143 "Carcinoma, Rectal" 17553685 Characterized mechanism of alpha-mangostin-induced cell death: caspase-independent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal cancer DLD-1 cells. -tissue_expression_up hsa-mir-126 "Leukemia-Lymphoma, Precursor B-Cell Lymphoblastic" 17604727 strongly expressed -tissue_expression_up hsa-let-7a-1 Heart Failure 17606841 upregulated -tissue_expression_up hsa-let-7a-2 Heart Failure 17606841 upregulated -tissue_expression_up hsa-let-7b Heart Failure 17606841 upregulated -tissue_expression_up hsa-let-7c Heart Failure 17606841 upregulated -tissue_expression_up hsa-let-7d Heart Failure 17606841 upregulated -tissue_expression_up hsa-let-7e Heart Failure 17606841 upregulated -tissue_expression_up hsa-let-7f-1 Heart Failure 17606841 upregulated -tissue_expression_up hsa-let-7f-2 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-106b Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-10b Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-1-1 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-1-2 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-125a Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-126 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-129-2 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-130a Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-132 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-196a-1 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-196a-2 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-199b Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-200c Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-204 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-205 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-208a Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-21 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-210 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-211 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-212 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-215 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-26a-1 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-26a-2 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-28 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-296 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-297 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-29a Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-29b-1 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-300 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-302a Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-32 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-320a Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-330 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-340 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-34b Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-365a Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-365b Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-367 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-372 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-373 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-377 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-381 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-382 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-423 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-424 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-429 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-432 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-500a Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-520c Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-525 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-98 Heart Failure 17606841 upregulated -tissue_expression_up hsa-mir-146a Psoriasis 17622355 miR-146a was significantly over-expressed in psoriatic lesional skin p<0.001) but not in atopic eczema lesions when compared with healthy skin. -tissue_expression_up hsa-mir-203 Psoriasis 17622355 upregulation (lead to downregulation of its target SOCS3) -tissue_expression_up hsa-mir-21 Atopic Dermatitis 17622355 miR-21 was significantly up-regulated both psoriasis (p<0.001) and atopic eczema (p<0.001) as compared with healthy skin. -tissue_expression_up hsa-mir-21 Psoriasis 17622355 miR-21 was significantly up-regulated both psoriasis (p<0.001) and atopic eczema (p<0.001) as compared with healthy skin. -tissue_expression_up hsa-mir-221 Glioblastoma 17627278 "Interestingly, high levels of miR-221&222 appear in glioblastomas and correlate with low levels of p27(Kip1) protein. Thus, deregulated expression of miR-221&222 promotes cancerous growth by inhibiting the expression of p27(Kip1)." -tissue_expression_up hsa-mir-222 Glioblastoma 17627278 "Interestingly, high levels of miR-221&222 appear in glioblastomas and correlate with low levels of p27(Kip1) protein. Thus, deregulated expression of miR-221&222 promotes cancerous growth by inhibiting the expression of p27(Kip1)." -tissue_expression_up hsa-mir-103-1 Bladder Neoplasms 17826655 "Human micro-RNAs miR-223, miR-26b, miR-221, miR-103-1, miR-185, miR-23b, miR-203, miR-17-5p, miR-23a, and miR-205 were significantly up-regulated in bladder cancers (P < 0.05) compared to normal bladder mucosa." -tissue_expression_up hsa-mir-17 Bladder Neoplasms 17826655 "Human micro-RNAs miR-223, miR-26b, miR-221, miR-103-1, miR-185, miR-23b, miR-203, miR-17-5p, miR-23a, and miR-205 were significantly up-regulated in bladder cancers (P < 0.05) compared to normal bladder mucosa." -tissue_expression_up hsa-mir-185 Bladder Neoplasms 17826655 "Human micro-RNAs miR-223, miR-26b, miR-221, miR-103-1, miR-185, miR-23b, miR-203, miR-17-5p, miR-23a, and miR-205 were significantly up-regulated in bladder cancers (P < 0.05) compared to normal bladder mucosa." -tissue_expression_up hsa-mir-203 Bladder Neoplasms 17826655 "Human micro-RNAs miR-223, miR-26b, miR-221, miR-103-1, miR-185, miR-23b, miR-203, miR-17-5p, miR-23a, and miR-205 were significantly up-regulated in bladder cancers (P < 0.05) compared to normal bladder mucosa." -tissue_expression_up hsa-mir-205 Bladder Neoplasms 17826655 "Human micro-RNAs miR-223, miR-26b, miR-221, miR-103-1, miR-185, miR-23b, miR-203, miR-17-5p, miR-23a, and miR-205 were significantly up-regulated in bladder cancers (P < 0.05) compared to normal bladder mucosa." -tissue_expression_up hsa-mir-221 Bladder Neoplasms 17826655 "Human micro-RNAs miR-223, miR-26b, miR-221, miR-103-1, miR-185, miR-23b, miR-203, miR-17-5p, miR-23a, and miR-205 were significantly up-regulated in bladder cancers (P < 0.05) compared to normal bladder mucosa." -tissue_expression_up hsa-mir-223 Bladder Neoplasms 17826655 "Human micro-RNAs miR-223, miR-26b, miR-221, miR-103-1, miR-185, miR-23b, miR-203, miR-17-5p, miR-23a, and miR-205 were significantly up-regulated in bladder cancers (P < 0.05) compared to normal bladder mucosa." -tissue_expression_up hsa-mir-23a Bladder Neoplasms 17826655 "Human micro-RNAs miR-223, miR-26b, miR-221, miR-103-1, miR-185, miR-23b, miR-203, miR-17-5p, miR-23a, and miR-205 were significantly up-regulated in bladder cancers (P < 0.05) compared to normal bladder mucosa." -tissue_expression_up hsa-mir-23b Bladder Neoplasms 17826655 "Human micro-RNAs miR-223, miR-26b, miR-221, miR-103-1, miR-185, miR-23b, miR-203, miR-17-5p, miR-23a, and miR-205 were significantly up-regulated in bladder cancers (P < 0.05) compared to normal bladder mucosa." -tissue_expression_up hsa-mir-26b Bladder Neoplasms 17826655 "Human micro-RNAs miR-223, miR-26b, miR-221, miR-103-1, miR-185, miR-23b, miR-203, miR-17-5p, miR-23a, and miR-205 were significantly up-regulated in bladder cancers (P < 0.05) compared to normal bladder mucosa." -tissue_expression_up hsa-mir-140 Ovarian Neoplasms 17875710 "The most significantly overexpressed miRNAs were miR-200a, miR-141, miR-200c, and miR-200b, whereas miR-199a, miR-140, miR-145, and miR-125b1 were among the most down-modulated miRNAs." -tissue_expression_up hsa-mir-141 Ovarian Neoplasms 17875710 "The most significantly overexpressed miRNAs were miR-200a, miR-141, miR-200c, and miR-200b, whereas miR-199a, miR-140, miR-145, and miR-125b1 were among the most down-modulated miRNAs." -tissue_expression_up hsa-mir-145 Ovarian Neoplasms 17875710 "The most significantly overexpressed miRNAs were miR-200a, miR-141, miR-200c, and miR-200b, whereas miR-199a, miR-140, miR-145, and miR-125b1 were among the most down-modulated miRNAs." -tissue_expression_up hsa-mir-199a Ovarian Neoplasms 17875710 "The most significantly overexpressed miRNAs were miR-200a, miR-141, miR-200c, and miR-200b, whereas miR-199a, miR-140, miR-145, and miR-125b1 were among the most down-modulated miRNAs." -tissue_expression_up hsa-mir-200a Ovarian Neoplasms 17875710 "The most significantly overexpressed miRNAs were miR-200a, miR-141, miR-200c, and miR-200b, whereas miR-199a, miR-140, miR-145, and miR-125b1 were among the most down-modulated miRNAs." -tissue_expression_up hsa-mir-200b Ovarian Neoplasms 17875710 "The most significantly overexpressed miRNAs were miR-200a, miR-141, miR-200c, and miR-200b, whereas miR-199a, miR-140, miR-145, and miR-125b1 were among the most down-modulated miRNAs." -tissue_expression_up hsa-mir-200c Ovarian Neoplasms 17875710 "The most significantly overexpressed miRNAs were miR-200a, miR-141, miR-200c, and miR-200b, whereas miR-199a, miR-140, miR-145, and miR-125b1 were among the most down-modulated miRNAs." -tissue_expression_up hsa-mir-34a Colon Neoplasms 17875987 highly upregulated -tissue_expression_up hsa-mir-34a Neuroblastoma 17888029 All of the Fe-NTA-induced rat renal carcinomas and an array of human cancers (151 positive cases of 177) showed high expression of miRNA-34a. -tissue_expression_up hsa-mir-183 Retinitis Pigmentosa 18034880 "Expression of miR-1 and miR-133 decreased by more than 2.5-fold (P < 0.001), whereas expression of miR-96 and miR-183 increased by more than 3-fold (P < 0.001) in Pro347Ser retinas, as validated by qPCR." -tissue_expression_up hsa-mir-96 Retinitis Pigmentosa 18034880 "Expression of miR-1 and miR-133 decreased by more than 2.5-fold (P < 0.001), whereas expression of miR-96 and miR-183 increased by more than 3-fold (P < 0.001) in Pro347Ser retinas, as validated by qPCR." -tissue_expression_up hsa-let-7g Schizophrenia 18184693 upregulated -tissue_expression_up hsa-let-7i Neoplasms [unspecific] 18187804 "Changing the cellular levels of let-7i, mir-16, and mir-21 affected the potencies of a number of the anticancer agents by up to 4-fold." -tissue_expression_up hsa-mir-16 Neoplasms [unspecific] 18187804 "Changing the cellular levels of let-7i, mir-16, and mir-21 affected the potencies of a number of the anticancer agents by up to 4-fold." -tissue_expression_up hsa-mir-21 Neoplasms [unspecific] 18187804 "Changing the cellular levels of let-7i, mir-16, and mir-21 affected the potencies of a number of the anticancer agents by up to 4-fold." -tissue_expression_up hsa-mir-21 "Carcinoma, Rectal" 18196926 "Expression levels of analyzed miRNAs significantly differed among tumors and adjacent non-tumor tissues: miR-21 (p = 0.0001) and miR-31 (p = 0.0006) were upregulated, and miR-143 (p = 0.011) and miR-145 (p = 0.003) were downregulated in tumors." -tissue_expression_up hsa-mir-31 "Carcinoma, Rectal" 18196926 "Expression levels of analyzed miRNAs significantly differed among tumors and adjacent non-tumor tissues: miR-21 (p = 0.0001) and miR-31 (p = 0.0006) were upregulated, and miR-143 (p = 0.011) and miR-145 (p = 0.003) were downregulated in tumors." -tissue_expression_up hsa-mir-203 Esophageal Neoplasms 18242245 Both mir_203 and mir_205 were expressed 2- to 10-fold lower in squamous cell carcinoma and adenocarcinomas than in normal epithelium. -tissue_expression_up hsa-mir-205 Esophageal Neoplasms 18242245 Both mir_203 and mir_205 were expressed 2- to 10-fold lower in squamous cell carcinoma and adenocarcinomas than in normal epithelium. -tissue_expression_up hsa-mir-100 "Carcinoma, Hepatocellular" 18307259 "miR-122, miR-100, and miR-10a were overexpressed whereas miR-198 and miR-145 were up to 5-fold down-regulated in hepatic tumors compared to normal liver parenchyma." -tissue_expression_up hsa-mir-10a "Carcinoma, Hepatocellular" 18307259 "miR-122, miR-100, and miR-10a were overexpressed whereas miR-198 and miR-145 were up to 5-fold down-regulated in hepatic tumors compared to normal liver parenchyma." -tissue_expression_up hsa-mir-122 "Carcinoma, Hepatocellular" 18307259 "miR-122, miR-100, and miR-10a were overexpressed whereas miR-198 and miR-145 were up to 5-fold down-regulated in hepatic tumors compared to normal liver parenchyma." -tissue_expression_up hsa-mir-191 Neoplasms [unspecific] 18375788 increased -tissue_expression_up hsa-mir-146a Rheumatoid Arthritis 18383392 This study provides the first description of increased expression of miRNA miR-155 and miR-146a in RA. -tissue_expression_up hsa-mir-155 Rheumatoid Arthritis 18383392 This study provides the first description of increased expression of miRNA miR-155 and miR-146a in RA. -tissue_expression_up hsa-mir-221 Neoplasms [unspecific] 18413744 "Thus, the physiologic up-regulation of miR-221 and miR-222 is tightly linked to a cell cycle checkpoint that ensures cell survival by coordinating competency for initiation of S phase with growth factor signaling pathways that stimulate cell proliferation." -tissue_expression_up hsa-mir-222 Neoplasms [unspecific] 18413744 "Thus, the physiologic up-regulation of miR-221 and miR-222 is tightly linked to a cell cycle checkpoint that ensures cell survival by coordinating competency for initiation of S phase with growth factor signaling pathways that stimulate cell proliferation." -tissue_expression_up hsa-mir-126 "Carcinoma, Hepatocellular" 18433021 "miR-96 was overexpressed in HBV tumors, and miR-126* was down-regulated in alcohol-related hepatocellular carcinoma." -tissue_expression_up hsa-mir-141 Ovarian Neoplasms 18451233 Higher -tissue_expression_up hsa-mir-18a Ovarian Neoplasms 18451233 Higher -tissue_expression_up hsa-mir-429 Ovarian Neoplasms 18451233 Higher -tissue_expression_up hsa-mir-93 Ovarian Neoplasms 18451233 Higher -tissue_expression_up hsa-mir-150 Retinal Neovascularization 18500251 increased -tissue_expression_up hsa-mir-184 Retinal Neovascularization 18500251 increased -tissue_expression_up hsa-mir-31 Retinal Neovascularization 18500251 increased -tissue_expression_up hsa-mir-451a Retinal Neovascularization 18500251 increased -tissue_expression_up hsa-mir-21 Ovarian Neoplasms 18560586 "we identify several miRNAs aberrantly expressed in human ovarian cancer tissues and cell lines. miR-221 stands out as a highly elevated miRNA in ovarian cancer, while miR-21 and several members of the let-7 family are found downregulated." -tissue_expression_up hsa-mir-146b Thyroid Neoplasms 18587330 miR-146b: overexpressed -tissue_expression_up hsa-mir-221 Thyroid Neoplasms 18587330 miR-221: overexpressed -tissue_expression_up hsa-mir-222 Thyroid Neoplasms 18587330 miR-222: overexpressed -tissue_expression_up hsa-mir-146a Urinary Bladder Cancer 18596939 miR-146a: upregulated -tissue_expression_up hsa-mir-155 Urinary Bladder Cancer 18596939 miR-155: upregulated -tissue_expression_up hsa-mir-15b Urinary Bladder Cancer 18596939 miR-15b: upregulated -tissue_expression_up hsa-mir-16-1 Urinary Bladder Cancer 18596939 miR-16: upregulated -tissue_expression_up hsa-mir-16-2 Urinary Bladder Cancer 18596939 miR-16: upregulated -tissue_expression_up hsa-mir-21 Pancreatic Neoplasms 18642050 miR-21: MicroRNA-21 is overexpressed in pancreatic cancer and a potential predictor of survival -tissue_expression_up hsa-let-7f "Carcinoma, Pancreatic" 18665421 "In addition, when analyzed according to specific cancer phenotypes, miR-15a and miR-16 show a significant downregulation in canine ductal carcinomas while miRsR-181b, -21, -29b, and let-7f show a significant upregulation in canine tubular papillary carcinomas." -tissue_expression_up hsa-mir-181b "Carcinoma, Pancreatic" 18665421 "In addition, when analyzed according to specific cancer phenotypes, miR-15a and miR-16 show a significant downregulation in canine ductal carcinomas while miRsR-181b, -21, -29b, and let-7f show a significant upregulation in canine tubular papillary carcinomas." -tissue_expression_up hsa-mir-21 "Carcinoma, Pancreatic" 18665421 "In addition, when analyzed according to specific cancer phenotypes, miR-15a and miR-16 show a significant downregulation in canine ductal carcinomas while miRsR-181b, -21, -29b, and let-7f show a significant upregulation in canine tubular papillary carcinomas." -tissue_expression_up hsa-mir-29b "Carcinoma, Pancreatic" 18665421 "In addition, when analyzed according to specific cancer phenotypes, miR-15a and miR-16 show a significant downregulation in canine ductal carcinomas while miRsR-181b, -21, -29b, and let-7f show a significant upregulation in canine tubular papillary carcinomas." -tissue_expression_up hsa-mir-106b Prostate Neoplasms 18676839 miR-106b: significantly higher expression -tissue_expression_up hsa-mir-25 Prostate Neoplasms 18676839 miR-25: significantly higher expression -tissue_expression_up hsa-mir-32 Prostate Neoplasms 18676839 miR-32: significantly higher expression -tissue_expression_up hsa-mir-93 Prostate Neoplasms 18676839 miR-93: significantly higher expression -tissue_expression_up hsa-mir-205 "Carcinoma, Lung, Non-Small-Cell" 18719201 miR-205: overexpression -tissue_expression_up hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 18719201 miR-21: overexpression -tissue_expression_up hsa-mir-146a Rheumatoid Arthritis 18759964 miR-146a: Upregulated miR-146a expression in peripheral blood mononuclear cells -tissue_expression_up hsa-let-7a-1 Head And Neck Neoplasms 18798260 let-7a: overexpressed -tissue_expression_up hsa-let-7a-2 Head And Neck Neoplasms 18798260 let-7a: overexpressed -tissue_expression_up hsa-let-7a-3 Head And Neck Neoplasms 18798260 let-7a: overexpressed -tissue_expression_up hsa-let-7b Head And Neck Neoplasms 18798260 let-7b: overexpressed -tissue_expression_up hsa-let-7c Head And Neck Neoplasms 18798260 let-7c: overexpressed -tissue_expression_up hsa-let-7d Head And Neck Neoplasms 18798260 let-7d: overexpressed -tissue_expression_up hsa-let-7e Head And Neck Neoplasms 18798260 let-7e: overexpressed -tissue_expression_up hsa-let-7f-1 Head And Neck Neoplasms 18798260 let-7f: overexpressed -tissue_expression_up hsa-let-7f-2 Head And Neck Neoplasms 18798260 let-7f: overexpressed -tissue_expression_up hsa-let-7g Head And Neck Neoplasms 18798260 let-7g: overexpressed -tissue_expression_up hsa-let-7i Head And Neck Neoplasms 18798260 let-7i: overexpressed -tissue_expression_up hsa-mir-142 Head And Neck Neoplasms 18798260 miR-142-3p: overexpressed -tissue_expression_up hsa-mir-146b Head And Neck Neoplasms 18798260 miR-146b: overexpressed -tissue_expression_up hsa-mir-155 Head And Neck Neoplasms 18798260 miR-155: overexpressed -tissue_expression_up hsa-mir-18a Head And Neck Neoplasms 18798260 miR-18: overexpressed -tissue_expression_up hsa-mir-18b Head And Neck Neoplasms 18798260 miR-18: overexpressed -tissue_expression_up hsa-mir-21 Head And Neck Neoplasms 18798260 miR-21: overexpressed -tissue_expression_up hsa-mir-29c Head And Neck Neoplasms 18798260 miR-29c: overexpressed -tissue_expression_up hsa-mir-143 Obesity 18809385 miR-143: Up-regulated expression of microRNA-143 in association with obesity in adipose -tissue_expression_up hsa-mir-204 Breast Neoplasms 18922924 miR-204: upregulated -tissue_expression_up hsa-mir-510 Breast Neoplasms 18922924 miR-510: upregulated -tissue_expression_up hsa-mir-135b Prostate Neoplasms 18949015 miR-135b: up-regulated -tissue_expression_up hsa-mir-194-1 Prostate Neoplasms 18949015 miR-194: up-regulated -tissue_expression_up hsa-mir-194-2 Prostate Neoplasms 18949015 miR-194: up-regulated -tissue_expression_up hsa-mir-126 Ovarian Neoplasms 18954897 miR-126: over-expressed -tissue_expression_up hsa-mir-21 Ovarian Neoplasms 18954897 miR-21: over-expressed -tissue_expression_up hsa-mir-29a Ovarian Neoplasms 18954897 miR-29a: over-expressed -tissue_expression_up hsa-mir-92b Ovarian Neoplasms 18954897 miR-92: over-expressed -tissue_expression_up hsa-mir-93 Ovarian Neoplasms 18954897 miR-93: over-expressed -tissue_expression_up hsa-mir-106a Gastric Neoplasms 18996365 "The level of miR-106a in cancer tissues was significantly higher than that in non-tumor tissues, with an average 1.625-fold increase. miR-106a level was significantly associated with tumor stage, size and differentiation; lymphatic and distant metastasis; and invasion (P<0.01)." -tissue_expression_up hsa-mir-15b Pancreatic Neoplasms 19030927 miR-15b: upregulated -tissue_expression_up hsa-mir-186 Pancreatic Neoplasms 19030927 miR-186: upregulated -tissue_expression_up hsa-mir-190a Pancreatic Neoplasms 19030927 miR-190: upregulated -tissue_expression_up hsa-mir-196a-1 Pancreatic Neoplasms 19030927 miR-196a: upregulated -tissue_expression_up hsa-mir-196a-2 Pancreatic Neoplasms 19030927 miR-196a: upregulated -tissue_expression_up hsa-mir-200b Pancreatic Neoplasms 19030927 miR-200b: upregulated -tissue_expression_up hsa-mir-221 Pancreatic Neoplasms 19030927 miR-221: upregulated -tissue_expression_up hsa-mir-222 Pancreatic Neoplasms 19030927 miR-222: upregulated -tissue_expression_up hsa-mir-95 Pancreatic Neoplasms 19030927 miR-95: upregulated -tissue_expression_up hsa-mir-221 "Carcinoma, Thyroid, Papillary" 19030936 Primary or mature miR-221 were overexpressed in PTC as compared with HT-ori3. -tissue_expression_up hsa-mir-103a-1 "Adenocarcinoma, Endometrial" 19065659 miR-103: upregulated -tissue_expression_up hsa-mir-103a-2 "Adenocarcinoma, Endometrial" 19065659 miR-103: upregulated -tissue_expression_up hsa-mir-106a "Adenocarcinoma, Endometrial" 19065659 miR-106a: upregulated -tissue_expression_up hsa-mir-151a "Adenocarcinoma, Endometrial" 19065659 miR-151: upregulated -tissue_expression_up hsa-mir-155 "Adenocarcinoma, Endometrial" 19065659 miR-155: upregulated -tissue_expression_up hsa-mir-182 "Adenocarcinoma, Endometrial" 19065659 miR-182: upregulated -tissue_expression_up hsa-mir-183 "Adenocarcinoma, Endometrial" 19065659 miR-183: upregulated -tissue_expression_up hsa-mir-194-1 "Adenocarcinoma, Endometrial" 19065659 miR-194: upregulated -tissue_expression_up hsa-mir-194-2 "Adenocarcinoma, Endometrial" 19065659 miR-194: upregulated -tissue_expression_up hsa-mir-200a "Adenocarcinoma, Endometrial" 19065659 miR-200a: upregulated -tissue_expression_up hsa-mir-200c "Adenocarcinoma, Endometrial" 19065659 miR-200c: upregulated -tissue_expression_up hsa-mir-203 "Adenocarcinoma, Endometrial" 19065659 miR-203: upregulated -tissue_expression_up hsa-mir-205 "Adenocarcinoma, Endometrial" 19065659 miR-205: upregulated -tissue_expression_up hsa-mir-210 "Adenocarcinoma, Endometrial" 19065659 miR-210: upregulated -tissue_expression_up hsa-mir-223 "Adenocarcinoma, Endometrial" 19065659 miR-223: upregulated -tissue_expression_up hsa-mir-95 "Adenocarcinoma, Endometrial" 19065659 miR-95: upregulated -tissue_expression_up hsa-mir-100 Endometriosis 19074548 miR-100: upregulated -tissue_expression_up hsa-mir-1-1 Endometriosis 19074548 miR-1: upregulated -tissue_expression_up hsa-mir-1-2 Endometriosis 19074548 miR-1: upregulated -tissue_expression_up hsa-mir-125a Endometriosis 19074548 miR-125a: upregulated -tissue_expression_up hsa-mir-125b-1 Endometriosis 19074548 miR-125b: upregulated -tissue_expression_up hsa-mir-125b-2 Endometriosis 19074548 miR-125b: upregulated -tissue_expression_up hsa-mir-126 Endometriosis 19074548 miR-126: upregulated -tissue_expression_up hsa-mir-143 Endometriosis 19074548 miR-143: upregulated -tissue_expression_up hsa-mir-145 Endometriosis 19074548 miR-145: upregulated -tissue_expression_up hsa-mir-150 Endometriosis 19074548 miR-150: upregulated -tissue_expression_up hsa-mir-194-1 Endometriosis 19074548 miR-194: upregulated -tissue_expression_up hsa-mir-194-2 Endometriosis 19074548 miR-194: upregulated -tissue_expression_up hsa-mir-223 Endometriosis 19074548 miR-223: upregulated -tissue_expression_up hsa-mir-29c Endometriosis 19074548 miR-29c: upregulated -tissue_expression_up hsa-mir-365a Endometriosis 19074548 miR-365: upregulated -tissue_expression_up hsa-mir-365b Endometriosis 19074548 miR-365: upregulated -tissue_expression_up hsa-mir-99a Endometriosis 19074548 miR-99a: upregulated -tissue_expression_up hsa-mir-99b Endometriosis 19074548 miR-99b: upregulated -tissue_expression_up hsa-mir-205 "Adenocarcinoma, Endometrial" 19077565 miR-205: upregulated -tissue_expression_up hsa-mir-429 "Adenocarcinoma, Endometrial" 19077565 miR-429: upregulated -tissue_expression_up hsa-mir-449a "Adenocarcinoma, Endometrial" 19077565 miR-449: upregulated -tissue_expression_up hsa-mir-449b "Adenocarcinoma, Endometrial" 19077565 miR-449: upregulated -tissue_expression_up hsa-mir-21 Breast Ductal Carcinoma 19080492 miR-21: expression is significantly higher than the normal controls -tissue_expression_up hsa-mir-223 Ischemia-Reperfusion Injury 19104939 miR-223: miR-223 expression levels were greatly up-regulated in the livers after 75 min ischemia followed by 120 min reperfusion when compared to sham controls -tissue_expression_up hsa-mir-210 Neoplasms [unspecific] 19141645 "two miRs, miR-210 and miR-373, are up-regulated in a hypoxia-inducible factor-1alpha-dependent manner in hypoxic cells" -tissue_expression_up hsa-mir-373 Neoplasms [unspecific] 19141645 "two miRs, miR-210 and miR-373, are up-regulated in a hypoxia-inducible factor-1alpha-dependent manner in hypoxic cells" -tissue_expression_up hsa-mir-150 Gastric Neoplasms 19148490 miR-150: patients with high expression levels have lower survival time -tissue_expression_up hsa-mir-20b Gastric Neoplasms 19148490 miR-20b: patients with high expression levels have lower survival time -tissue_expression_up hsa-mir-34b Gastric Neoplasms 19148490 miR-34b: upregulated in undifferentiated gastric cancer -tissue_expression_up hsa-mir-34c Gastric Neoplasms 19148490 miR-34c: upregulated in undifferentiated gastric cancer -tissue_expression_up hsa-mir-21 Astrocytoma 19159078 miR-21: upregulation -tissue_expression_up hsa-mir-221 Astrocytoma 19159078 miR-221: upregulation -tissue_expression_up hsa-mir-155 Neoplasms [unspecific] 19175697 "The expression of a subset of miRs (e.g. miR-21 and miR-155) was found to be consistently up-regulated, whereas another subset of miRs (e.g.miR-143 and miR-145) was consistently down-regulated across different cancer types suggesting their involvement in regulating common cellular processes whose deregulation may lead to tumourigenesis." -tissue_expression_up hsa-mir-21 Neoplasms [unspecific] 19175697 "The expression of a subset of miRs (e.g. miR-21 and miR-155) was found to be consistently up-regulated, whereas another subset of miRs (e.g.miR-143 and miR-145) was consistently down-regulated across different cancer types suggesting their involvement in regulating common cellular processes whose deregulation may lead to tumourigenesis." -tissue_expression_up hsa-mir-106b Gastric Neoplasms 19175831 miR-106b: overexpressed -tissue_expression_up hsa-mir-17 Gastric Neoplasms 19175831 miR-17: overexpressed -tissue_expression_up hsa-mir-18a Gastric Neoplasms 19175831 miR-18a: overexpressed -tissue_expression_up hsa-mir-18b Gastric Neoplasms 19175831 miR-18b: overexpressed -tissue_expression_up hsa-mir-19a Gastric Neoplasms 19175831 miR-19a: overexpressed -tissue_expression_up hsa-mir-20a Gastric Neoplasms 19175831 miR-20a: overexpressed -tissue_expression_up hsa-mir-20b Gastric Neoplasms 19175831 miR-20b: overexpressed -tissue_expression_up hsa-mir-21 Gastric Neoplasms 19175831 miR-21: overexpressed -tissue_expression_up hsa-mir-340 Gastric Neoplasms 19175831 miR-340*: overexpressed -tissue_expression_up hsa-mir-421 Gastric Neoplasms 19175831 miR-421: overexpressed -tissue_expression_up hsa-mir-658 Gastric Neoplasms 19175831 miR-658: overexpressed -tissue_expression_up hsa-mir-21 Head And Neck Neoplasms 19179615 miR-21: is frequently overexpressed in human HNSCC -tissue_expression_up hsa-mir-146a Hepatitis B Virus Infection 19187610 miR-146a: up-regulated -tissue_expression_up hsa-mir-181a-2 Hepatitis B Virus Infection 19187610 miR-181a: up-regulated -tissue_expression_up hsa-mir-181b-1 Hepatitis B Virus Infection 19187610 miR-181b: up-regulated -tissue_expression_up hsa-mir-181b-2 Hepatitis B Virus Infection 19187610 miR-181b: up-regulated -tissue_expression_up hsa-mir-200a Hepatitis B Virus Infection 19187610 miR-200: up-regulated -tissue_expression_up hsa-mir-200b Hepatitis B Virus Infection 19187610 miR-200: up-regulated -tissue_expression_up hsa-mir-200c Hepatitis B Virus Infection 19187610 miR-200: up-regulated -tissue_expression_up hsa-mir-17 Colorectal Carcinoma 19201770 miR-17-3p: up-regulated both in plasma and tissue samples -tissue_expression_up hsa-mir-21 Breast Neoplasms 19212625 "miR-21: upregulated, The expression levels of miR-21 were correlated with PTEN and commonly used clinicopathologic features of breast cancer" -tissue_expression_up hsa-mir-155 "Carcinoma, Renal Cell" 19228262 miR-155: overexpressed in malignant cancer than non-malignant one -tissue_expression_up hsa-mir-16-1 "Carcinoma, Renal Cell" 19228262 miR-16: overexpressed in malignant cancer than non-malignant one -tissue_expression_up hsa-mir-16-2 "Carcinoma, Renal Cell" 19228262 miR-16: overexpressed in malignant cancer than non-malignant one -tissue_expression_up hsa-mir-210 "Carcinoma, Renal Cell" 19228262 miR-210: overexpressed in malignant cancer than non-malignant one -tissue_expression_up hsa-mir-224 "Carcinoma, Renal Cell" 19228262 miR-224: overexpressed in malignant cancer than non-malignant one -tissue_expression_up hsa-mir-452 "Carcinoma, Renal Cell" 19228262 miR-452*: overexpressed in malignant cancer than non-malignant one -tissue_expression_up hsa-mir-21 Esophageal Neoplasms 19276261 "miR-21: overexpressed compared with with matched normal epitheliums, regulates the proliferation and invasion" -tissue_expression_up hsa-mir-143 Endotoxemia 19284987 "Data analysis revealed that five miRNAs consistently responded to LPS-infusion, four of which were down-regulated (miR-146b, miR-150, miR-342, and let-7g) and one was up-regulated (miR-143). The miR-150 and mir-342 response was confirmed by real-time PCR." -tissue_expression_up hsa-mir-17 Colorectal Carcinoma 19287964 miR-17-5p: up-regulated -tissue_expression_up hsa-mir-183 Colorectal Carcinoma 19287964 miR-183: up-regulated -tissue_expression_up hsa-mir-18a Colorectal Carcinoma 19287964 miR-18a: up-regulated -tissue_expression_up hsa-mir-20a Colorectal Carcinoma 19287964 miR-20a: up-regulated -tissue_expression_up hsa-mir-31 Colorectal Carcinoma 19287964 miR-31: up-regulated -tissue_expression_up hsa-mir-92b Colorectal Carcinoma 19287964 miR-92: up-regulated -tissue_expression_up hsa-mir-155 Breast Neoplasms 19290006 "Compared with normal breast samples, a panel of miRs was consistently dysregulated in breast cancer, including earlier-reported breast cancer-related miRs, such as upregulated miR-21, miR-155, miR-191, and miR-196a, and downregulated miR-125b and miR-221." -tissue_expression_up hsa-mir-191 Breast Neoplasms 19290006 "Compared with normal breast samples, a panel of miRs was consistently dysregulated in breast cancer, including earlier-reported breast cancer-related miRs, such as upregulated miR-21, miR-155, miR-191, and miR-196a, and downregulated miR-125b and miR-221." -tissue_expression_up hsa-mir-196a Breast Neoplasms 19290006 "Compared with normal breast samples, a panel of miRs was consistently dysregulated in breast cancer, including earlier-reported breast cancer-related miRs, such as upregulated miR-21, miR-155, miR-191, and miR-196a, and downregulated miR-125b and miR-221." -tissue_expression_up hsa-mir-21 Breast Neoplasms 19290006 "Compared with normal breast samples, a panel of miRs was consistently dysregulated in breast cancer, including earlier-reported breast cancer-related miRs, such as upregulated miR-21, miR-155, miR-191, and miR-196a, and downregulated miR-125b and miR-221." -tissue_expression_up hsa-mir-21 Cholangiocarcinoma 19296468 miR-21: overexpressed -tissue_expression_up hsa-mir-299 Primary Biliary Cirrhosis 19345069 A total of 35 independent miRNAs were found to be differentially expressed in PBC (p < 0.001).Quantitative PCR was employed to validate down-regulation of microRNA-122a (miR-122a) and miR-26a and the increased expression of miR-328 and miR-299-5p. -tissue_expression_up hsa-mir-328 Primary Biliary Cirrhosis 19345069 A total of 35 independent miRNAs were found to be differentially expressed in PBC (p < 0.001).Quantitative PCR was employed to validate down-regulation of microRNA-122a (miR-122a) and miR-26a and the increased expression of miR-328 and miR-299-5p. -tissue_expression_up hsa-mir-140 Salivary Gland Neoplasms 19347935 miR-140: up-regulated -tissue_expression_up hsa-mir-154 Salivary Gland Neoplasms 19347935 miR-154: up-regulated -tissue_expression_up hsa-mir-188 Salivary Gland Neoplasms 19347935 miR-188: up-regulated -tissue_expression_up hsa-mir-21 Salivary Gland Neoplasms 19347935 miR-21: up-regulated -tissue_expression_up hsa-mir-23b Salivary Gland Neoplasms 19347935 miR-23b: up-regulated -tissue_expression_up hsa-mir-299 Salivary Gland Neoplasms 19347935 miR-299-3p: up-regulated -tissue_expression_up hsa-mir-29c Salivary Gland Neoplasms 19347935 miR-29c: up-regulated -tissue_expression_up hsa-mir-301a Salivary Gland Neoplasms 19347935 miR-301: up-regulated -tissue_expression_up hsa-mir-301b Salivary Gland Neoplasms 19347935 miR-301: up-regulated -tissue_expression_up hsa-mir-302c Salivary Gland Neoplasms 19347935 miR-302c: up-regulated -tissue_expression_up hsa-mir-337 Salivary Gland Neoplasms 19347935 miR-337: up-regulated -tissue_expression_up hsa-mir-376a-1 Salivary Gland Neoplasms 19347935 miR-376a: up-regulated -tissue_expression_up hsa-mir-376a-2 Salivary Gland Neoplasms 19347935 miR-376a: up-regulated -tissue_expression_up hsa-mir-409 Salivary Gland Neoplasms 19347935 miR-409-3p: up-regulated -tissue_expression_up hsa-mir-449a Salivary Gland Neoplasms 19347935 miR-449: up-regulated -tissue_expression_up hsa-mir-449b Salivary Gland Neoplasms 19347935 miR-449: up-regulated -tissue_expression_up hsa-mir-495 Salivary Gland Neoplasms 19347935 miR-495: up-regulated -tissue_expression_up hsa-mir-99b Salivary Gland Neoplasms 19347935 miR-99b: up-regulated -tissue_expression_up hsa-mir-130b Head And Neck Neoplasms 19351747 miR-130b: up-regulated -tissue_expression_up hsa-mir-181a-2 Head And Neck Neoplasms 19351747 miR-181a: up-regulated -tissue_expression_up hsa-mir-181b-1 Head And Neck Neoplasms 19351747 miR-181b: up-regulated -tissue_expression_up hsa-mir-181b-2 Head And Neck Neoplasms 19351747 miR-181b: up-regulated -tissue_expression_up hsa-mir-181d Head And Neck Neoplasms 19351747 miR-181d: up-regulated -tissue_expression_up hsa-mir-18a Head And Neck Neoplasms 19351747 miR-18a: up-regulated -tissue_expression_up hsa-mir-193b Head And Neck Neoplasms 19351747 miR-193b: up-regulated -tissue_expression_up hsa-mir-21 Head And Neck Neoplasms 19351747 miR-21: up-regulated -tissue_expression_up hsa-mir-221 Head And Neck Neoplasms 19351747 miR-221: up-regulated -tissue_expression_up hsa-mir-455 Head And Neck Neoplasms 19351747 miR-455: up-regulated -tissue_expression_up hsa-mir-491 Head And Neck Neoplasms 19351747 miR-491: up-regulated -tissue_expression_up hsa-let-7a-1 "Carcinoma, Adrenocortical" 19351815 let-7a: upregulated -tissue_expression_up hsa-let-7a-2 "Carcinoma, Adrenocortical" 19351815 let-7a: upregulated -tissue_expression_up hsa-let-7a-3 "Carcinoma, Adrenocortical" 19351815 let-7a: upregulated -tissue_expression_up hsa-let-7b "Carcinoma, Adrenocortical" 19351815 let-7b: upregulated -tissue_expression_up hsa-let-7c "Carcinoma, Adrenocortical" 19351815 let-7c: upregulated -tissue_expression_up hsa-let-7d "Carcinoma, Adrenocortical" 19351815 let-7d: upregulated -tissue_expression_up hsa-mir-100 "Carcinoma, Adrenocortical" 19351815 miR-100: upregulated -tissue_expression_up hsa-mir-1-1 "Carcinoma, Adrenocortical" 19351815 miR-1: upregulated -tissue_expression_up hsa-mir-1-2 "Carcinoma, Adrenocortical" 19351815 miR-1: upregulated -tissue_expression_up hsa-mir-125b-1 "Carcinoma, Adrenocortical" 19351815 miR-125b: upregulated -tissue_expression_up hsa-mir-125b-2 "Carcinoma, Adrenocortical" 19351815 miR-125b: upregulated -tissue_expression_up hsa-mir-126 "Carcinoma, Adrenocortical" 19351815 miR-126: upregulated -tissue_expression_up hsa-mir-130a "Carcinoma, Adrenocortical" 19351815 miR-130a: upregulated -tissue_expression_up hsa-mir-132 "Carcinoma, Adrenocortical" 19351815 miR-132: upregulated -tissue_expression_up hsa-mir-133a-1 "Carcinoma, Adrenocortical" 19351815 miR-133a: upregulated -tissue_expression_up hsa-mir-133a-2 "Carcinoma, Adrenocortical" 19351815 miR-133a: upregulated -tissue_expression_up hsa-mir-135a-1 "Carcinoma, Adrenocortical" 19351815 miR-135a: upregulated -tissue_expression_up hsa-mir-135a-2 "Carcinoma, Adrenocortical" 19351815 miR-135a: upregulated -tissue_expression_up hsa-mir-137 "Carcinoma, Adrenocortical" 19351815 miR-137: upregulated -tissue_expression_up hsa-mir-143 "Carcinoma, Adrenocortical" 19351815 miR-143: upregulated -tissue_expression_up hsa-mir-145 "Carcinoma, Adrenocortical" 19351815 miR-145: upregulated -tissue_expression_up hsa-mir-146a "Carcinoma, Adrenocortical" 19351815 miR-146a: upregulated -tissue_expression_up hsa-mir-155 "Carcinoma, Adrenocortical" 19351815 miR-155: upregulated -tissue_expression_up hsa-mir-15b "Carcinoma, Adrenocortical" 19351815 miR-15b: upregulated -tissue_expression_up hsa-mir-16-1 "Carcinoma, Adrenocortical" 19351815 miR-16: upregulated -tissue_expression_up hsa-mir-16-2 "Carcinoma, Adrenocortical" 19351815 miR-16: upregulated -tissue_expression_up hsa-mir-17 "Carcinoma, Adrenocortical" 19351815 miR-17-5p: upregulated -tissue_expression_up hsa-mir-192 "Carcinoma, Adrenocortical" 19351815 miR-192: upregulated -tissue_expression_up hsa-mir-194-1 "Carcinoma, Adrenocortical" 19351815 miR-194: upregulated -tissue_expression_up hsa-mir-194-2 "Carcinoma, Adrenocortical" 19351815 miR-194: upregulated -tissue_expression_up hsa-mir-200b "Carcinoma, Adrenocortical" 19351815 miR-200b: upregulated -tissue_expression_up hsa-mir-200c "Carcinoma, Adrenocortical" 19351815 miR-200c: upregulated -tissue_expression_up hsa-mir-203 "Carcinoma, Adrenocortical" 19351815 miR-203: upregulated -tissue_expression_up hsa-mir-222 "Carcinoma, Adrenocortical" 19351815 miR-222: upregulated -tissue_expression_up hsa-mir-23b "Carcinoma, Adrenocortical" 19351815 miR-23b: upregulated -tissue_expression_up hsa-mir-28 "Carcinoma, Adrenocortical" 19351815 miR-28: upregulated -tissue_expression_up hsa-mir-30a "Carcinoma, Adrenocortical" 19351815 miR-30a-3p: upregulated -tissue_expression_up hsa-mir-335 "Carcinoma, Adrenocortical" 19351815 miR-335: upregulated -tissue_expression_up hsa-mir-375 "Carcinoma, Adrenocortical" 19351815 miR-375: upregulated -tissue_expression_up hsa-mir-449a "Carcinoma, Adrenocortical" 19351815 miR-449: upregulated -tissue_expression_up hsa-mir-449b "Carcinoma, Adrenocortical" 19351815 miR-449: upregulated -tissue_expression_up hsa-mir-7-1 "Carcinoma, Adrenocortical" 19351815 miR-7: upregulated -tissue_expression_up hsa-mir-7-2 "Carcinoma, Adrenocortical" 19351815 miR-7: upregulated -tissue_expression_up hsa-mir-7-3 "Carcinoma, Adrenocortical" 19351815 miR-7: upregulated -tissue_expression_up hsa-mir-221 Prostate Neoplasms 19351832 miR-221: Overexpression -tissue_expression_up hsa-mir-222 Prostate Neoplasms 19351832 miR-222: Overexpression -tissue_expression_up hsa-mir-100 "Carcinoma, Hepatocellular" 19360909 miR-100: overexpressed In HCC patients with hepatitis C and liver cirrhosis -tissue_expression_up hsa-mir-10a "Carcinoma, Hepatocellular" 19360909 miR-10a: overexpressed In HCC patients with hepatitis C and liver cirrhosis -tissue_expression_up hsa-mir-203 "Carcinoma, Hepatocellular" 19360909 miR-203: up-regulated in HCC compared to benign hepatocellular tumors -tissue_expression_up hsa-mir-21 "Carcinoma, Hepatocellular" 19360909 miR-21: up-regulated in HCC compared to benign hepatocellular tumors -tissue_expression_up hsa-mir-221 "Carcinoma, Hepatocellular" 19360909 miR-221: up-regulated in HCC compared to benign hepatocellular tumors -tissue_expression_up hsa-mir-222 "Carcinoma, Hepatocellular" 19360909 miR-222: up-regulated in HCC compared to benign hepatocellular tumors -tissue_expression_up hsa-mir-224 "Carcinoma, Hepatocellular" 19360909 miR-224: up-regulated in HCC compared to benign hepatocellular tumors -tissue_expression_up hsa-mir-34a "Carcinoma, Hepatocellular" 19360909 miR-34a: up-regulated in HCC compared to benign hepatocellular tumors -tissue_expression_up hsa-mir-342 Breast Neoplasms 19432961 MiR-342 expression was highest in ER and HER2/neu-positive luminal B tumours and lowest in triple-negative tumours. MiR-520g expression was elevated in ER and PR-negative tumours. -tissue_expression_up hsa-mir-520g Breast Neoplasms 19432961 MiR-342 expression was highest in ER and HER2/neu-positive luminal B tumours and lowest in triple-negative tumours. MiR-520g expression was elevated in ER and PR-negative tumours. -tissue_expression_up hsa-mir-27a Ovarian Neoplasms 19446316 High expression of hsa-mir-27a identified a sub-group of patients with very poor prognosis. -tissue_expression_up hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 19446359 Mir-21 expression in the sputum specimens was significantly higher in cancer patients (76.32+/-9.79) than cancer-free individuals (62.24+/-3.82) (P<0.0001). -tissue_expression_up hsa-mir-335 Obesity 19460359 These findings provide the first evidence that the up-regulated expressions of miR-335 in liver and WAT of obese mice might contribute to the pathophysiology of obesity. -tissue_expression_up hsa-mir-150 Inflammation 19525145 "Specifically, recent studies indicate that those miRNAs that are selectively and/or highly expressed in immune cells including the miR-17-92 cluster, miR-150, miR-155, miR-181 and miR-223 have a 'permissive' function in the maturation, proliferation and differentiation of myeloid and lymphoid cells." -tissue_expression_up hsa-mir-155 Inflammation 19525145 "Specifically, recent studies indicate that those miRNAs that are selectively and/or highly expressed in immune cells including the miR-17-92 cluster, miR-150, miR-155, miR-181 and miR-223 have a 'permissive' function in the maturation, proliferation and differentiation of myeloid and lymphoid cells." -tissue_expression_up hsa-mir-17 Inflammation 19525145 "Specifically, recent studies indicate that those miRNAs that are selectively and/or highly expressed in immune cells including the miR-17-92 cluster, miR-150, miR-155, miR-181 and miR-223 have a 'permissive' function in the maturation, proliferation and differentiation of myeloid and lymphoid cells." -tissue_expression_up hsa-mir-18 Inflammation 19525145 "Specifically, recent studies indicate that those miRNAs that are selectively and/or highly expressed in immune cells including the miR-17-92 cluster, miR-150, miR-155, miR-181 and miR-223 have a 'permissive' function in the maturation, proliferation and differentiation of myeloid and lymphoid cells." -tissue_expression_up hsa-mir-181 Inflammation 19525145 "Specifically, recent studies indicate that those miRNAs that are selectively and/or highly expressed in immune cells including the miR-17-92 cluster, miR-150, miR-155, miR-181 and miR-223 have a 'permissive' function in the maturation, proliferation and differentiation of myeloid and lymphoid cells." -tissue_expression_up hsa-mir-19a Inflammation 19525145 "Specifically, recent studies indicate that those miRNAs that are selectively and/or highly expressed in immune cells including the miR-17-92 cluster, miR-150, miR-155, miR-181 and miR-223 have a 'permissive' function in the maturation, proliferation and differentiation of myeloid and lymphoid cells." -tissue_expression_up hsa-mir-19b-1 Inflammation 19525145 "Specifically, recent studies indicate that those miRNAs that are selectively and/or highly expressed in immune cells including the miR-17-92 cluster, miR-150, miR-155, miR-181 and miR-223 have a 'permissive' function in the maturation, proliferation and differentiation of myeloid and lymphoid cells." -tissue_expression_up hsa-mir-20a Inflammation 19525145 "Specifically, recent studies indicate that those miRNAs that are selectively and/or highly expressed in immune cells including the miR-17-92 cluster, miR-150, miR-155, miR-181 and miR-223 have a 'permissive' function in the maturation, proliferation and differentiation of myeloid and lymphoid cells." -tissue_expression_up hsa-mir-223 Inflammation 19525145 "Specifically, recent studies indicate that those miRNAs that are selectively and/or highly expressed in immune cells including the miR-17-92 cluster, miR-150, miR-155, miR-181 and miR-223 have a 'permissive' function in the maturation, proliferation and differentiation of myeloid and lymphoid cells." -tissue_expression_up hsa-mir-92-1 Inflammation 19525145 "Specifically, recent studies indicate that those miRNAs that are selectively and/or highly expressed in immune cells including the miR-17-92 cluster, miR-150, miR-155, miR-181 and miR-223 have a 'permissive' function in the maturation, proliferation and differentiation of myeloid and lymphoid cells." -tissue_expression_up hsa-mir-30a "Squamous Cell Carcinoma, Esophageal" 19536617 high expression levels; might play a important role in the development of the cancer -tissue_expression_up hsa-mir-210 Adrenal Cortex Neoplasms 19546168 significantly higher expressed -tissue_expression_up hsa-mir-503 Adrenal Cortex Neoplasms 19546168 significantly higher expressed -tissue_expression_up hsa-mir-15a Pancreatic Neoplasms 19551852 differentially expressed; associates with poorer survival -tissue_expression_up hsa-mir-203 Pancreatic Neoplasms 19551852 differentially expressed; associates with poorer survival -tissue_expression_up hsa-mir-210 Pancreatic Neoplasms 19551852 differentially expressed; associates with poorer survival -tissue_expression_up hsa-mir-222 Pancreatic Neoplasms 19551852 differentially expressed; associates with poorer survival -tissue_expression_up hsa-mir-1224 Fatty Liver [unspecific] 19572984 expression increased after Lieber-DeCarli or MCD; -tissue_expression_up hsa-mir-182 Fatty Liver [unspecific] 19572984 expression increased after Lieber-DeCarli or MCD; -tissue_expression_up hsa-mir-146a Melanoma 19578755 overexpressed -tissue_expression_up hsa-mir-17 Melanoma 19578755 miR-17-5p; overexpressed -tissue_expression_up hsa-mir-18a Melanoma 19578755 overexpressed -tissue_expression_up hsa-mir-20a Melanoma 19578755 overexpressed -tissue_expression_up hsa-mir-155 Myocardial Infarction 19581315 "Overexpressed; arrhythmogenic miR-1, contributing to ischaemic arrhythmogenesis stimulated by beta-adrenergic pathway; downregulatied by propranolol together with SRF" -tissue_expression_up hsa-mir-221 "Carcinoma, Hepatocellular" 19585654 critical player; up-regulated; could directly target hepatic transcriptional regulators of differentiation and an inhibitor of Wnt/beta-catenin signaling -tissue_expression_up hsa-mir-17 Lung Neoplasms 19597473 miR-17-5p ; frequent overexpression -tissue_expression_up hsa-mir-20a Lung Neoplasms 19597473 miR-17-92 overexpression may serve as a fine-tuning influence to counterbalance the generation of DNA damage -tissue_expression_up hsa-mir-18a Breast Neoplasms 19624877 Differential expression profiles of microRNAs between breast cancer cells and mammary epithelial cells: mir-18a and mir-195 were highly expressed in MCF-7 cells; target genes of mir-200b were predicted by informatics analysis. -tissue_expression_up hsa-mir-200b Breast Neoplasms 19624877 Differential expression profiles of microRNAs between breast cancer cells and mammary epithelial cells: mir-18a and mir-195 were highly expressed in MCF-7 cells; target genes of mir-200b were predicted by informatics analysis. -tissue_expression_up hsa-mir-223 Breast Neoplasms 19624877 Differential expression profiles of microRNAs between breast cancer cells and mammary epithelial cells: mir-18a and mir-195 were highly expressed in MCF-7 cells; target genes of mir-200b were predicted by informatics analysis. -tissue_expression_up hsa-mir-195 Eclampsia 19642860 increased in placenta -tissue_expression_up hsa-mir-21 Eclampsia 19642860 increased in placenta -tissue_expression_up hsa-mir-222 Eclampsia 19642860 increased in placenta -tissue_expression_up hsa-mir-26b Eclampsia 19642860 increased in placenta -tissue_expression_up hsa-mir-335 Eclampsia 19642860 increased in placenta -tissue_expression_up hsa-mir-155 Neoplasms [unspecific] 19652553 "overexpression, target MYC antagonist MNT" -tissue_expression_up hsa-mir-137 Colon Neoplasms 19659786 "expressed differently, miR-137 upregulated in non-cancerous colonic tissues from colon cancer patients with lymph node metastasis" -tissue_expression_up hsa-mir-221 Cholesteatoma 19672202 up-regulated concurrent with down-regulation of PTEN -tissue_expression_up hsa-mir-21 "Adenocarcinoma, Colon" 19672269 expression Increased -tissue_expression_up hsa-mir-183 Neoplasms [unspecific] 19676045 up-regulated -tissue_expression_up hsa-mir-96 Neoplasms [unspecific] 19676045 up-regulated -tissue_expression_up hsa-mir-21 Alzheimer Disease 19683563 "up-regulated, inhibits bcl2 translation" -tissue_expression_up hsa-mir-18a Breast Neoplasms 19684618 higher levels of expression in ERalpha-negative tumors -tissue_expression_up hsa-mir-34a Breast Neoplasms 19684618 higher levels of expression in ERalpha-negative tumors -tissue_expression_up hsa-mir-107 "Diabetes Mellitus, Type 2" 19689793 over-expressed in insulin target tissues -tissue_expression_up hsa-mir-125a Hepatoblastoma 19701500 upregulated -tissue_expression_up hsa-mir-150 Hepatoblastoma 19701500 upregulated -tissue_expression_up hsa-mir-214 Hepatoblastoma 19701500 upregulated -tissue_expression_up hsa-mir-208a Cardiomegaly 19726871 overexpression -tissue_expression_up hsa-mir-155 "Leukemia, Myeloid, Acute" 19744129 "Their aberrant expression has been associated with solid tumors and hematopoietic malignancies as suggested by the frequent deletion of mir-15a and mir-16-1 in chronic lymphocytic leukemia, the increased levels of mir-155 in diffuse large B-cell lymphomas and the increased levels of mir-181 in acute myeloid leukemia M1 and M2. " -tissue_expression_up hsa-mir-155 "Lymphoma, Large B-Cell, Diffuse" 19744129 "Their aberrant expression has been associated with solid tumors and hematopoietic malignancies as suggested by the frequent deletion of mir-15a and mir-16-1 in chronic lymphocytic leukemia, the increased levels of mir-155 in diffuse large B-cell lymphomas and the increased levels of mir-181 in acute myeloid leukemia M1 and M2. " -tissue_expression_up hsa-mir-130a Lung Neoplasms 19748927 "miR-21, mir-31, miR-130a, miR-146b and miR-377 were consistently upregulated, whereas miR-1 and miR-143 were downregulated in lung tumors relative to normal lungs." -tissue_expression_up hsa-mir-146b Lung Neoplasms 19748927 "miR-21, mir-31, miR-130a, miR-146b and miR-377 were consistently upregulated, whereas miR-1 and miR-143 were downregulated in lung tumors relative to normal lungs." -tissue_expression_up hsa-mir-21 Lung Neoplasms 19748927 "miR-21, mir-31, miR-130a, miR-146b and miR-377 were consistently upregulated, whereas miR-1 and miR-143 were downregulated in lung tumors relative to normal lungs." -tissue_expression_up hsa-mir-31 Lung Neoplasms 19748927 "miR-21, mir-31, miR-130a, miR-146b and miR-377 were consistently upregulated, whereas miR-1 and miR-143 were downregulated in lung tumors relative to normal lungs." -tissue_expression_up hsa-mir-377 Lung Neoplasms 19748927 "miR-21, mir-31, miR-130a, miR-146b and miR-377 were consistently upregulated, whereas miR-1 and miR-143 were downregulated in lung tumors relative to normal lungs." -tissue_expression_up hsa-mir-192 Squamous Cell Carcinoma 19789312 "In adenocarcinoma patients, miR-21, miR-223, miR-192, and miR-194 expression was elevated, whereas miR-203 expression was reduced in cancerous compared with noncancerous tissue." -tissue_expression_up hsa-mir-194 Squamous Cell Carcinoma 19789312 "In adenocarcinoma patients, miR-21, miR-223, miR-192, and miR-194 expression was elevated, whereas miR-203 expression was reduced in cancerous compared with noncancerous tissue." -tissue_expression_up hsa-mir-21 Squamous Cell Carcinoma 19789312 "In adenocarcinoma patients, miR-21, miR-223, miR-192, and miR-194 expression was elevated, whereas miR-203 expression was reduced in cancerous compared with noncancerous tissue." -tissue_expression_up hsa-mir-223 Squamous Cell Carcinoma 19789312 "In adenocarcinoma patients, miR-21, miR-223, miR-192, and miR-194 expression was elevated, whereas miR-203 expression was reduced in cancerous compared with noncancerous tissue." -tissue_expression_up hsa-mir-29a Lung Neoplasms 19818597 "MiRNA expression profiling of human NSCLC cell lines indicated that miR-29a levels were reduced in more invasive cell lines. Exogenous overexpression of miR-29a in both lung and pancreatic cancer cell lines resulted in a significant reduction in the invasion phenotype, as well as in proliferation." -tissue_expression_up hsa-mir-15b Melanoma 19830692 "MiR-15b:MiR-15b and miR-210 were significantly upregulated, miR-34a was significantly downregulated in melanomas" -tissue_expression_up hsa-mir-210 Melanoma 19830692 "miR-210:MiR-15b and miR-210 were significantly upregulated, miR-34a was significantly downregulated in melanomas" -tissue_expression_up hsa-mir-210 Adrenal Cortex Neoplasms 19849700 up-regulated -tissue_expression_up hsa-mir-484 Adrenal Cortex Neoplasms 19849700 up-regulated -tissue_expression_up hsa-mir-193b Hematologic Neoplasms 19883314 miR-193b-365 significantly up-regulated in MM -tissue_expression_up hsa-mir-200a "Adenocarcinoma, Endometrial" 19891660 up-regulated -tissue_expression_up hsa-mir-200b "Adenocarcinoma, Endometrial" 19891660 up-regulated -tissue_expression_up hsa-mir-205 "Adenocarcinoma, Endometrial" 19891660 up-regulated -tissue_expression_up hsa-mir-141 Nephrosclerosis 19910931 significantly higher in patients with hypertensive nephrosclerosis than controls -tissue_expression_up hsa-mir-192 Nephrosclerosis 19910931 significantly higher in patients with hypertensive nephrosclerosis than controls -tissue_expression_up hsa-mir-200a Nephrosclerosis 19910931 significantly higher in patients with hypertensive nephrosclerosis than controls -tissue_expression_up hsa-mir-200b Nephrosclerosis 19910931 significantly higher in patients with hypertensive nephrosclerosis than controls -tissue_expression_up hsa-mir-205 Nephrosclerosis 19910931 significantly higher in patients with hypertensive nephrosclerosis than controls -tissue_expression_up hsa-mir-429 Nephrosclerosis 19910931 significantly higher in patients with hypertensive nephrosclerosis than controls -tissue_expression_up hsa-mir-223 Rheumatoid Arthritis 19931339 miR-223 is overexpressed in T-lymphocytes of patients affected by rheumatoid arthritis. -tissue_expression_up hsa-mir-17 "Lymphoma, B-Cell" 19945163 miR-17-5p:the detection of upregulation of miR-17-5p and miR-181a in B- and T-cell lymphomas respectively -tissue_expression_up hsa-mir-17 "Lymphoma, T-Cell" 19945163 miR-17-5p:the detection of upregulation of miR-17-5p and miR-181a in B- and T-cell lymphomas respectively -tissue_expression_up hsa-mir-181a-1 "Lymphoma, B-Cell" 19945163 miR-181a:the detection of upregulation of miR-17-5p and miR-181a in B- and T-cell lymphomas respectively -tissue_expression_up hsa-mir-181a-1 "Lymphoma, T-Cell" 19945163 miR-181a:the detection of upregulation of miR-17-5p and miR-181a in B- and T-cell lymphomas respectively -tissue_expression_up hsa-mir-181a-2 "Lymphoma, B-Cell" 19945163 miR-181a:the detection of upregulation of miR-17-5p and miR-181a in B- and T-cell lymphomas respectively -tissue_expression_up hsa-mir-181a-2 "Lymphoma, T-Cell" 19945163 miR-181a:the detection of upregulation of miR-17-5p and miR-181a in B- and T-cell lymphomas respectively -tissue_expression_up hsa-mir-629 Breast Neoplasms 19946373 upregulated -tissue_expression_up hsa-mir-629 Colon Neoplasms 19946373 upregulated -tissue_expression_up hsa-mir-629 Liver Neoplasms 19946373 upregulated -tissue_expression_up hsa-mir-629 Lung Neoplasms 19946373 upregulated -tissue_expression_up hsa-mir-629 Lymphoma 19946373 upregulated -tissue_expression_up hsa-mir-629 Ovarian Neoplasms 19946373 upregulated -tissue_expression_up hsa-mir-629 Prostate Neoplasms 19946373 upregulated -tissue_expression_up hsa-mir-629 Testicular Neoplasms 19946373 upregulated -tissue_expression_up hsa-mir-214 Gastric Neoplasms 20022810 high expression -tissue_expression_up hsa-mir-125a Retinal Degeneration 20053268 Over-expression -tissue_expression_up hsa-mir-204 Retinal Degeneration 20053268 Over-expression -tissue_expression_up hsa-mir-205 "Carcinoma, Lung, Non-Small-Cell" 20068099 hsa-miR-205 is a miRNA that is highly expressed in lung squamous cell carcinomas (SqCC) but not in lung adenocarcinomas. -tissue_expression_up hsa-mir-222 "Carcinoma, Hepatocellular" 20103675 overexpression -tissue_expression_up hsa-mir-106b Colon Neoplasms 20132431 "A total of 14 miRNAs were found to be associated with colonic cancer, in which the expression of miR-106b, miR-135b, miR-18a, miR-18b, miR-196b, miR-19a, miR-224, miR-335, miR-424, miR-20a*, miR-301b and miR-374a were up-regulated and the expression of miR-378 and miR-378* were downregulated in colonic cancer tissues, compared with the para-cancerous control." -tissue_expression_up hsa-mir-135b Colon Neoplasms 20132431 "A total of 14 miRNAs were found to be associated with colonic cancer, in which the expression of miR-106b, miR-135b, miR-18a, miR-18b, miR-196b, miR-19a, miR-224, miR-335, miR-424, miR-20a*, miR-301b and miR-374a were up-regulated and the expression of miR-378 and miR-378* were downregulated in colonic cancer tissues, compared with the para-cancerous control." -tissue_expression_up hsa-mir-18a Colon Neoplasms 20132431 "A total of 14 miRNAs were found to be associated with colonic cancer, in which the expression of miR-106b, miR-135b, miR-18a, miR-18b, miR-196b, miR-19a, miR-224, miR-335, miR-424, miR-20a*, miR-301b and miR-374a were up-regulated and the expression of miR-378 and miR-378* were downregulated in colonic cancer tissues, compared with the para-cancerous control." -tissue_expression_up hsa-mir-18b Colon Neoplasms 20132431 "A total of 14 miRNAs were found to be associated with colonic cancer, in which the expression of miR-106b, miR-135b, miR-18a, miR-18b, miR-196b, miR-19a, miR-224, miR-335, miR-424, miR-20a*, miR-301b and miR-374a were up-regulated and the expression of miR-378 and miR-378* were downregulated in colonic cancer tissues, compared with the para-cancerous control." -tissue_expression_up hsa-mir-196b Colon Neoplasms 20132431 "A total of 14 miRNAs were found to be associated with colonic cancer, in which the expression of miR-106b, miR-135b, miR-18a, miR-18b, miR-196b, miR-19a, miR-224, miR-335, miR-424, miR-20a*, miR-301b and miR-374a were up-regulated and the expression of miR-378 and miR-378* were downregulated in colonic cancer tissues, compared with the para-cancerous control." -tissue_expression_up hsa-mir-19a Colon Neoplasms 20132431 "A total of 14 miRNAs were found to be associated with colonic cancer, in which the expression of miR-106b, miR-135b, miR-18a, miR-18b, miR-196b, miR-19a, miR-224, miR-335, miR-424, miR-20a*, miR-301b and miR-374a were up-regulated and the expression of miR-378 and miR-378* were downregulated in colonic cancer tissues, compared with the para-cancerous control." -tissue_expression_up hsa-mir-20a Colon Neoplasms 20132431 "A total of 14 miRNAs were found to be associated with colonic cancer, in which the expression of miR-106b, miR-135b, miR-18a, miR-18b, miR-196b, miR-19a, miR-224, miR-335, miR-424, miR-20a*, miR-301b and miR-374a were up-regulated and the expression of miR-378 and miR-378* were downregulated in colonic cancer tissues, compared with the para-cancerous control." -tissue_expression_up hsa-mir-224 Colon Neoplasms 20132431 "A total of 14 miRNAs were found to be associated with colonic cancer, in which the expression of miR-106b, miR-135b, miR-18a, miR-18b, miR-196b, miR-19a, miR-224, miR-335, miR-424, miR-20a*, miR-301b and miR-374a were up-regulated and the expression of miR-378 and miR-378* were downregulated in colonic cancer tissues, compared with the para-cancerous control." -tissue_expression_up hsa-mir-301b Colon Neoplasms 20132431 "A total of 14 miRNAs were found to be associated with colonic cancer, in which the expression of miR-106b, miR-135b, miR-18a, miR-18b, miR-196b, miR-19a, miR-224, miR-335, miR-424, miR-20a*, miR-301b and miR-374a were up-regulated and the expression of miR-378 and miR-378* were downregulated in colonic cancer tissues, compared with the para-cancerous control." -tissue_expression_up hsa-mir-335 Colon Neoplasms 20132431 "A total of 14 miRNAs were found to be associated with colonic cancer, in which the expression of miR-106b, miR-135b, miR-18a, miR-18b, miR-196b, miR-19a, miR-224, miR-335, miR-424, miR-20a*, miR-301b and miR-374a were up-regulated and the expression of miR-378 and miR-378* were downregulated in colonic cancer tissues, compared with the para-cancerous control." -tissue_expression_up hsa-mir-374a Colon Neoplasms 20132431 "A total of 14 miRNAs were found to be associated with colonic cancer, in which the expression of miR-106b, miR-135b, miR-18a, miR-18b, miR-196b, miR-19a, miR-224, miR-335, miR-424, miR-20a*, miR-301b and miR-374a were up-regulated and the expression of miR-378 and miR-378* were downregulated in colonic cancer tissues, compared with the para-cancerous control." -tissue_expression_up hsa-mir-424 Colon Neoplasms 20132431 "A total of 14 miRNAs were found to be associated with colonic cancer, in which the expression of miR-106b, miR-135b, miR-18a, miR-18b, miR-196b, miR-19a, miR-224, miR-335, miR-424, miR-20a*, miR-301b and miR-374a were up-regulated and the expression of miR-378 and miR-378* were downregulated in colonic cancer tissues, compared with the para-cancerous control." -tissue_expression_up hsa-let-7i Neoplasms [unspecific] 20145181 overexpression -tissue_expression_up hsa-let-7i "Squamous Cell Carcinoma, Head and Neck" 20145181 overexpression -tissue_expression_up hsa-mir-106b Neoplasms [unspecific] 20145181 Upregulation -tissue_expression_up hsa-mir-106b "Squamous Cell Carcinoma, Head and Neck" 20145181 Upregulation -tissue_expression_up hsa-mir-142 Neoplasms [unspecific] 20145181 overexpression -tissue_expression_up hsa-mir-142 "Squamous Cell Carcinoma, Head and Neck" 20145181 miR-142-3p; overexpression -tissue_expression_up hsa-mir-155 Neoplasms [unspecific] 20145181 overexpression -tissue_expression_up hsa-mir-155 "Squamous Cell Carcinoma, Head and Neck" 20145181 overexpression -tissue_expression_up hsa-mir-16-1 Neoplasms [unspecific] 20145181 Upregulation -tissue_expression_up hsa-mir-16-2 Neoplasms [unspecific] 20145181 Upregulation -tissue_expression_up hsa-mir-20a Neoplasms [unspecific] 20145181 Upregulation -tissue_expression_up hsa-mir-20a "Squamous Cell Carcinoma, Head and Neck" 20145181 Upregulation -tissue_expression_up hsa-mir-21 Neoplasms [unspecific] 20145181 overexpression -tissue_expression_up hsa-mir-21 "Squamous Cell Carcinoma, Head and Neck" 20145181 overexpression -tissue_expression_up hsa-mir-423 Neoplasms [unspecific] 20145181 Upregulation -tissue_expression_up hsa-mir-423 "Squamous Cell Carcinoma, Head and Neck" 20145181 Upregulation -tissue_expression_up hsa-mir-142 Neoplasms [unspecific] 20178649 "Most of the differentially expressed miRNAs were downregulated in germinomas, but miR-142-5p and miR-146a were upregulated." -tissue_expression_up hsa-mir-146a Neoplasms [unspecific] 20178649 "Most of the differentially expressed miRNAs were downregulated in germinomas, but miR-142-5p and miR-146a were upregulated." -tissue_expression_up hsa-mir-451 Polycythemia Vera 20218812 We observed that miR-451 up-regulation and miR-150 down-regulation are associated with progression of erythroid maturation in K562 cells. -tissue_expression_up hsa-mir-21 Astrocytoma 20219352 "miR-21:hsa-miR-21, hsa-miR-181b and hsa-miR-106a as prognostic indicators of astrocytoma" -tissue_expression_up hsa-mir-182 "Leukemia, Biphenotypic, Acute" 20227111 miR-182:miR-584 and miR-182 upregulation in the CD34(+)CD38(-) fraction -tissue_expression_up hsa-mir-584 "Leukemia, Biphenotypic, Acute" 20227111 miR-584:miR-584 and miR-182 upregulation in the CD34(+)CD38(-) fraction -tissue_expression_up hsa-mir-136 Lung Neoplasms 20237410 "We found that miR-136, miR-376a, and miR-31 were each prominently overexpressed in murine lung cancers." -tissue_expression_up hsa-mir-31 Lung Neoplasms 20237410 "We found that miR-136, miR-376a, and miR-31 were each prominently overexpressed in murine lung cancers." -tissue_expression_up hsa-mir-376a-1 Lung Neoplasms 20237410 "We found that miR-136, miR-376a, and miR-31 were each prominently overexpressed in murine lung cancers." -tissue_expression_up hsa-mir-376a-2 Lung Neoplasms 20237410 "We found that miR-136, miR-376a, and miR-31 were each prominently overexpressed in murine lung cancers." -tissue_expression_up hsa-mir-17 Neoplasms [unspecific] 20299512 "The miR-17-92 cluster (encoding miR-17, -18a, -19a/b, -20a, and miR-92a) is highly expressed in tumor cells and is up-regulated by ischemia." -tissue_expression_up hsa-mir-18a Neoplasms [unspecific] 20299512 "The miR-17-92 cluster (encoding miR-17, -18a, -19a/b, -20a, and miR-92a) is highly expressed in tumor cells and is up-regulated by ischemia." -tissue_expression_up hsa-mir-19a Neoplasms [unspecific] 20299512 "The miR-17-92 cluster (encoding miR-17, -18a, -19a/b, -20a, and miR-92a) is highly expressed in tumor cells and is up-regulated by ischemia." -tissue_expression_up hsa-mir-19b-1 Neoplasms [unspecific] 20299512 "The miR-17-92 cluster (encoding miR-17, -18a, -19a/b, -20a, and miR-92a) is highly expressed in tumor cells and is up-regulated by ischemia." -tissue_expression_up hsa-mir-20a Neoplasms [unspecific] 20299512 "The miR-17-92 cluster (encoding miR-17, -18a, -19a/b, -20a, and miR-92a) is highly expressed in tumor cells and is up-regulated by ischemia." -tissue_expression_up hsa-mir-92a-1 Neoplasms [unspecific] 20299512 "The miR-17-92 cluster (encoding miR-17, -18a, -19a/b, -20a, and miR-92a) is highly expressed in tumor cells and is up-regulated by ischemia." -tissue_expression_up hsa-mir-143 "Adenocarcinoma, Esophageal" 20301167 upregulated -tissue_expression_up hsa-mir-145 "Adenocarcinoma, Esophageal" 20301167 upregulated -tissue_expression_up hsa-mir-203 "Adenocarcinoma, Esophageal" 20301167 miR-203:Levels of miR-203 and miR-205 were high in normal squamous epithelium and low in columnar epithelia -tissue_expression_up hsa-mir-205 "Adenocarcinoma, Esophageal" 20301167 miR-205:Levels of miR-203 and miR-205 were high in normal squamous epithelium and low in columnar epithelia -tissue_expression_up hsa-mir-21 "Adenocarcinoma, Esophageal" 20301167 upregulated -tissue_expression_up hsa-mir-215 "Adenocarcinoma, Esophageal" 20301167 upregulated -tissue_expression_up hsa-mir-183 Breast Neoplasms 20331864 up-regulated in male breast cancer -tissue_expression_up hsa-mir-197 Breast Neoplasms 20331864 up-regulated in male breast cancer -tissue_expression_up hsa-mir-21 Breast Neoplasms 20331864 up-regulated in male breast cancer -tissue_expression_up hsa-mir-493 Breast Neoplasms 20331864 up-regulated in male breast cancer -tissue_expression_up hsa-mir-519d Breast Neoplasms 20331864 up-regulated in male breast cancer -tissue_expression_up hsa-mir-302a Neoplasms [unspecific] 20332240 overexpressed -tissue_expression_up hsa-mir-302b Neoplasms [unspecific] 20332240 overexpressed -tissue_expression_up hsa-mir-302c Neoplasms [unspecific] 20332240 overexpressed -tissue_expression_up hsa-mir-302d Neoplasms [unspecific] 20332240 overexpressed -tissue_expression_up hsa-mir-302e Neoplasms [unspecific] 20332240 overexpressed -tissue_expression_up hsa-mir-302f Neoplasms [unspecific] 20332240 overexpressed -tissue_expression_up hsa-mir-371a Neoplasms [unspecific] 20332240 overexpressed -tissue_expression_up hsa-mir-372 Neoplasms [unspecific] 20332240 overexpressed -tissue_expression_up hsa-mir-373 Neoplasms [unspecific] 20332240 overexpressed -tissue_expression_up hsa-mir-193b Melanoma 20357817 "Furthermore, low expression of miR-191 and high expression of miR-193b were associated with poor melanoma-specific survive" -tissue_expression_up hsa-mir-21 Lung Neoplasms 20363096 "upregulated; Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis" -tissue_expression_up hsa-let-7a-1 Neoplasms [unspecific] 20370992 over-expressed -tissue_expression_up hsa-let-7a-2 Neoplasms [unspecific] 20370992 over-expressed -tissue_expression_up hsa-let-7a-3 Neoplasms [unspecific] 20370992 over-expressed -tissue_expression_up hsa-mir-182 Neoplasms [unspecific] 20370992 over-expressed -tissue_expression_up hsa-mir-21 Neoplasms [unspecific] 20370992 over-expressed -tissue_expression_up hsa-mir-21 Gastric Neoplasms 20372781 Expression of miR-21 in cancer tissues was significantly higher than in non-cancer tissues -tissue_expression_up hsa-mir-142 Glioblastoma 20380575 "miR-142-3p:The miR-17-3p, miR-17-5p, miR-19a, miR-19b, miR-142-3p, and miR-142-5p were upregulated in both M059K and M059J cells." -tissue_expression_up hsa-mir-143 Glioblastoma 20380575 "miR-143:The miR-15a, miR-16, miR-143, miR-155, and miR-21 were upregulated in M059K" -tissue_expression_up hsa-mir-155 Glioblastoma 20380575 "miR-155:The miR-15a, miR-16, miR-143, miR-155, and miR-21 were upregulated in M059K" -tissue_expression_up hsa-mir-15a Glioblastoma 20380575 "miR-15a:The miR-15a, miR-16, miR-143, miR-155, and miR-21 were upregulated in M059K" -tissue_expression_up hsa-mir-16-1 Glioblastoma 20380575 "miR-16:The miR-15a, miR-16, miR-143, miR-155, and miR-21 were upregulated in M059K" -tissue_expression_up hsa-mir-16-2 Glioblastoma 20380575 "miR-16:The miR-15a, miR-16, miR-143, miR-155, and miR-21 were upregulated in M059K" -tissue_expression_up hsa-mir-17 Glioblastoma 20380575 "miR-17-3p:The miR-17-3p, miR-17-5p, miR-19a, miR-19b, miR-142-3p, and miR-142-5p were upregulated in both M059K and M059J cells." -tissue_expression_up hsa-mir-19a Glioblastoma 20380575 "miR-19a:The miR-17-3p, miR-17-5p, miR-19a, miR-19b, miR-142-3p, and miR-142-5p were upregulated in both M059K and M059J cells." -tissue_expression_up hsa-mir-19b-1 Glioblastoma 20380575 "miR-19b:The miR-17-3p, miR-17-5p, miR-19a, miR-19b, miR-142-3p, and miR-142-5p were upregulated in both M059K and M059J cells." -tissue_expression_up hsa-mir-19b-2 Glioblastoma 20380575 "miR-19b:The miR-17-3p, miR-17-5p, miR-19a, miR-19b, miR-142-3p, and miR-142-5p were upregulated in both M059K and M059J cells." -tissue_expression_up hsa-mir-21 Glioblastoma 20380575 "miR-21:The miR-15a, miR-16, miR-143, miR-155, and miR-21 were upregulated in M059K" -tissue_expression_up hsa-mir-155 Breast Neoplasms 20388420 "The expression of miR-155 is up-regulated in primary breast cancer, especially in patients with positive estrogen and progesterone receptor." -tissue_expression_up hsa-mir-106a Glioma 20406893 "miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas," -tissue_expression_up hsa-mir-106b Glioma 20406893 "miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas," -tissue_expression_up hsa-mir-17 Glioma 20406893 "miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas," -tissue_expression_up hsa-mir-182 Glioma 20406893 "miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas," -tissue_expression_up hsa-mir-183 Glioma 20406893 "miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas," -tissue_expression_up hsa-mir-18a Glioma 20406893 "miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas," -tissue_expression_up hsa-mir-18b Glioma 20406893 "miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas," -tissue_expression_up hsa-mir-20a Glioma 20406893 "miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas," -tissue_expression_up hsa-mir-20b Glioma 20406893 "miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas," -tissue_expression_up hsa-mir-302a Glioma 20406893 "miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas," -tissue_expression_up hsa-mir-302b Glioma 20406893 "miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas," -tissue_expression_up hsa-mir-302c Glioma 20406893 "miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas," -tissue_expression_up hsa-mir-302d Glioma 20406893 "miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas," -tissue_expression_up hsa-mir-367 Glioma 20406893 "miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas," -tissue_expression_up hsa-mir-371a Glioma 20406893 "miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas," -tissue_expression_up hsa-mir-373 Glioma 20406893 "miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas," -tissue_expression_up hsa-mir-93 Glioma 20406893 "miR17 family, mir183-182, and the SC-specific clusters mir367-302 and mir371-373,which are upregulated in gliomas," -tissue_expression_up hsa-mir-133a-2 Colorectal Adenocarcinoma 20413677 "miR-133b:eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203,-133b, and -223) were over-expressed in CRC relative to mucosa," -tissue_expression_up hsa-mir-135a-1 Colorectal Adenocarcinoma 20413677 "miR-135a:eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203,-133b, and -223) were over-expressed in CRC relative to mucosa," -tissue_expression_up hsa-mir-135a-2 Colorectal Adenocarcinoma 20413677 "miR-135a:eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203,-133b, and -223) were over-expressed in CRC relative to mucosa," -tissue_expression_up hsa-mir-17 Colorectal Adenocarcinoma 20413677 "miR-17:eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203,-133b, and -223) were over-expressed in CRC relative to mucosa," -tissue_expression_up hsa-mir-183 Colorectal Adenocarcinoma 20413677 "miR-183:eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203,-133b, and -223) were over-expressed in CRC relative to mucosa," -tissue_expression_up hsa-mir-203 Colorectal Adenocarcinoma 20413677 "miR-203:eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203,-133b, and -223) were over-expressed in CRC relative to mucosa," -tissue_expression_up hsa-mir-20a Colorectal Adenocarcinoma 20413677 "miR-20:eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203,-133b, and -223) were over-expressed in CRC relative to mucosa," -tissue_expression_up hsa-mir-223 Colorectal Adenocarcinoma 20413677 "miR-223:eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203,-133b, and -223) were over-expressed in CRC relative to mucosa," -tissue_expression_up hsa-mir-25 Colorectal Adenocarcinoma 20413677 "miR-25:eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203,-133b, and -223) were over-expressed in CRC relative to mucosa," -tissue_expression_up hsa-mir-31 Colorectal Adenocarcinoma 20413677 "miR-31:eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203,-133b, and -223) were over-expressed in CRC relative to mucosa," -tissue_expression_up hsa-mir-92a-1 Colorectal Adenocarcinoma 20413677 "miR-92:eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203,-133b, and -223) were over-expressed in CRC relative to mucosa," -tissue_expression_up hsa-mir-92a-2 Colorectal Adenocarcinoma 20413677 "miR-92:eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203,-133b, and -223) were over-expressed in CRC relative to mucosa," -tissue_expression_up hsa-mir-93 Colorectal Adenocarcinoma 20413677 "miR-93:eleven miRNAs (miR-183, -31, -20, -25, -92, -93, -17, -135a, -203,-133b, and -223) were over-expressed in CRC relative to mucosa," -tissue_expression_up hsa-mir-126 Lung Neoplasms 20418022 "This set includes hsa-miR-182, which was most strongly over-expressed in the lung primary tumors, and hsa-miR-126, which was over-expressed in the metastatic tumors." -tissue_expression_up hsa-mir-182 Lung Neoplasms 20418022 "This set includes hsa-miR-182, which was most strongly over-expressed in the lung primary tumors, and hsa-miR-126, which was over-expressed in the metastatic tumors." -tissue_expression_up hsa-mir-372 Liver Neoplasms 20423907 "microRNA-372:CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer" -tissue_expression_up hsa-mir-106a Toxoplasma gondii Infection 20423977 hsa-mir-106a:human miR-17 family members that are increased by infection with the intracellular parasite Toxoplasma gondii -tissue_expression_up hsa-mir-106b Toxoplasma gondii Infection 20423977 hsa-mir-106b:human miR-17 family members that are increased by infection with the intracellular parasite Toxoplasma gondii -tissue_expression_up hsa-mir-17 Toxoplasma gondii Infection 20423977 hsa-mir-17:human miR-17 family members that are increased by infection with the intracellular parasite Toxoplasma gondii -tissue_expression_up hsa-mir-18a Toxoplasma gondii Infection 20423977 hsa-mir-18a:human miR-17 family members that are increased by infection with the intracellular parasite Toxoplasma gondii -tissue_expression_up hsa-mir-18b Toxoplasma gondii Infection 20423977 hsa-mir-18b:human miR-17 family members that are increased by infection with the intracellular parasite Toxoplasma gondii -tissue_expression_up hsa-mir-20a Toxoplasma gondii Infection 20423977 hsa-mir-20a:human miR-17 family members that are increased by infection with the intracellular parasite Toxoplasma gondii -tissue_expression_up hsa-mir-20b Toxoplasma gondii Infection 20423977 hsa-mir-20b:human miR-17 family members that are increased by infection with the intracellular parasite Toxoplasma gondii -tissue_expression_up hsa-mir-93 Toxoplasma gondii Infection 20423977 hsa-mir-93:human miR-17 family members that are increased by infection with the intracellular parasite Toxoplasma gondii -tissue_expression_up hsa-mir-221 Glioblastoma 20428775 miR-221:STAT1/2 upregulation under the transcriptional control of INF-alpha signaling after knockdown of miR-221/222 cluster in U251 glioma cells -tissue_expression_up hsa-mir-222 Glioblastoma 20428775 miR-222:STAT1/2 upregulation under the transcriptional control of INF-alpha signaling after knockdown of miR-221/222 cluster in U251 glioma cells -tissue_expression_up hsa-mir-205 "Squamous Cell Carcinoma, Esophageal" 20428818 miR-205:miR-205 and miR-21 are specific markers for HNSCC and ESCC -tissue_expression_up hsa-mir-205 "Squamous Cell Carcinoma, Head and Neck" 20428818 miR-205:miR-205 and miR-21 are specific markers for HNSCC and ESCC -tissue_expression_up hsa-mir-21 "Squamous Cell Carcinoma, Esophageal" 20428818 miR-21:miR-205 and miR-21 are specific markers for HNSCC and ESCC -tissue_expression_up hsa-mir-21 "Squamous Cell Carcinoma, Head and Neck" 20428818 miR-21:miR-205 and miR-21 are specific markers for HNSCC and ESCC -tissue_expression_up hsa-mir-146a Melanoma 20442294 miR-146a:miR-146a and miR-155 were upregulated in all analyzed patients but none of the cell lines -tissue_expression_up hsa-mir-155 Melanoma 20442294 miR-155:miR-146a and miR-155 were upregulated in all analyzed patients but none of the cell lines -tissue_expression_up hsa-mir-208 "Cardiomyopathy, Dilated" 20447577 "Levels of miR-208, miR-208b, and miR-499 were higher in DCM patients than in controls." -tissue_expression_up hsa-mir-208b "Cardiomyopathy, Dilated" 20447577 "Levels of miR-208, miR-208b, and miR-499 were higher in DCM patients than in controls." -tissue_expression_up hsa-mir-499 "Cardiomyopathy, Dilated" 20447577 "Levels of miR-208, miR-208b, and miR-499 were higher in DCM patients than in controls." -tissue_expression_up hsa-mir-1-1 Rhabdomyosarcoma 20466878 miR-1:mRNA targets of miR-1 and miR-133a are up-regulated in rhabdomyosarcomas -tissue_expression_up hsa-mir-1-2 Rhabdomyosarcoma 20466878 miR-1:mRNA targets of miR-1 and miR-133a are up-regulated in rhabdomyosarcomas -tissue_expression_up hsa-mir-133a-1 Rhabdomyosarcoma 20466878 miR-133a:mRNA targets of miR-1 and miR-133a are up-regulated in rhabdomyosarcomas -tissue_expression_up hsa-mir-296 "Squamous Cell Carcinoma, Esophageal" 20485139 miR-296:MiR-296 might play important roles in the pathogenesis of esophageal cancer and considered as a potential target for this malignancy intervention -tissue_expression_up hsa-mir-206 Myotonic Muscular Dystrophy 20487562 microRNA-206:Overexpression of microRNA-206 in the skeletal muscle from myotonic dystrophy type 1 patients -tissue_expression_up hsa-mir-18a Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_up hsa-mir-21 Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_up hsa-mir-22 Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_up hsa-mir-31 Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_up hsa-mir-34a Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_up hsa-mir-412 Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_up hsa-mir-504 Lung Neoplasms 20508945 "Seven miRNAs of hsa-miR-21, hsa-miR-31, hsa-miR-34a, hsa-miR-22*, hsa-miR-504, hsa-miR-18a, and hsa-miR-412 were observed to be upregulated greater than twofold in the squamous cell lung carcinoma tissues compared with normal tissues, whereas 23 miRNAs of hsa-miR-30a, hsa-miR-30d, hsa-miR-126, hsa-miR-652, hsa-miR-100, hsa-miR-143, hsa-miR-130a, hsa-miR-145, hsa-miR-30e, hsa-miR-126*, hsa-miR-181a, hsa-miR-125b, hsa-miR-886-3p, hsa-miR-451, hsa-miR-29c, hsa-miR-26b, hsa-miR-101, hsa-miR-320, hsa-miR-30b, hsa-miR-886-5p, hsa-miR-29a, hsa-miR-26a, and hsa-miR-99a were found to be downregulated greater than twofold." -tissue_expression_up hsa-mir-106a Colon Neoplasms 20551304 miRNA expression profiles from 29 patients showed higher expression of miR-21 and miR-106a in patients with adenomas and CRCs compared with individuals free of colorectal neoplasia. -tissue_expression_up hsa-mir-21 "Carcinoma, Rectal" 20551304 miRNA expression profiles from 29 patients showed higher expression of miR-21 and miR-106a in patients with adenomas and CRCs compared with individuals free of colorectal neoplasia. -tissue_expression_up hsa-mir-155 "Colitis, Ulcerative" 20586854 miR-155:Upregulated miRNA may be responsible for the development of intestinal inflammation in UC -tissue_expression_up hsa-mir-21 "Colitis, Ulcerative" 20586854 miR-21:Upregulated miRNA may be responsible for the development of intestinal inflammation in UC -tissue_expression_up hsa-mir-183 "Carcinoma, Hepatocellular" 20602797 "Among the 25 HCC samples analyzed, microRNA-183 was significantly up-regulated (twofold to 367-fold) in 17 samples compared with the matching nontumoral liver tissues." -tissue_expression_up hsa-mir-103a-1 Breast Neoplasms 20603000 "miR-103:In human breast cancer, high levels of miR-103/107 are associated with metastasis and poor outcome" -tissue_expression_up hsa-mir-103a-2 Breast Neoplasms 20603000 "miR-103:In human breast cancer, high levels of miR-103/107 are associated with metastasis and poor outcome" -tissue_expression_up hsa-mir-107 Breast Neoplasms 20603000 "miR-107:In human breast cancer, high levels of miR-103/107 are associated with metastasis and poor outcome" -tissue_expression_up hsa-mir-126 "Carcinoma, Hepatocellular" 20619223 miR-126:hsa-miR-126 showed higher expression levels in hepatocellular carcinomas -tissue_expression_up hsa-mir-125a "Squamous Cell Carcinoma, Lung" 20620595 miR-125a-5p:The miRNAs miR-185 * and miR-125a-5p were significantly upregulated in lung SCC -tissue_expression_up hsa-mir-185 "Squamous Cell Carcinoma, Lung" 20620595 miR-185:The miRNAs miR-185 * and miR-125a-5p were significantly upregulated in lung SCC -tissue_expression_up hsa-mir-103a-1 Lung Neoplasms 20624269 "miR-103:we found significant overexpression of miR-103, miR-107, miR-301 and miR-338 in lung cancer cells as compared to HBECs" -tissue_expression_up hsa-mir-103a-2 Lung Neoplasms 20624269 "miR-103:we found significant overexpression of miR-103, miR-107, miR-301 and miR-338 in lung cancer cells as compared to HBECs" -tissue_expression_up hsa-mir-107 Lung Neoplasms 20624269 "miR-107:we found significant overexpression of miR-103, miR-107, miR-301 and miR-338 in lung cancer cells as compared to HBECs" -tissue_expression_up hsa-mir-301a Lung Neoplasms 20624269 "miR-301:we found significant overexpression of miR-103, miR-107, miR-301 and miR-338 in lung cancer cells as compared to HBECs" -tissue_expression_up hsa-mir-338 Lung Neoplasms 20624269 "miR-338:we found significant overexpression of miR-103, miR-107, miR-301 and miR-338 in lung cancer cells as compared to HBECs" -tissue_expression_up hsa-mir-1-1 Myelodysplastic Syndromes 20627384 miR-1:Evaluation in a larger cohort could confirm the up-regulation of the miR-1 in MDS -tissue_expression_up hsa-mir-1-2 Myelodysplastic Syndromes 20627384 miR-1:Evaluation in a larger cohort could confirm the up-regulation of the miR-1 in MDS -tissue_expression_up hsa-mir-1246 Adenovirus Infection 20634878 miR-1246:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-1247 Adenovirus Infection 20634878 miR-1247:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-1273a Adenovirus Infection 20634878 miR-1273:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-1302-1 Adenovirus Infection 20634878 miR-1302-1:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-1302-2 Adenovirus Infection 20634878 miR-1302-2:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-1302-3 Adenovirus Infection 20634878 miR-1302-3:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-1302-4 Adenovirus Infection 20634878 miR-1302-4:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-1302-5 Adenovirus Infection 20634878 miR-1302-5:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-1302-6 Adenovirus Infection 20634878 miR-1302-6:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-1302-7 Adenovirus Infection 20634878 miR-1302-7:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-1302-8 Adenovirus Infection 20634878 miR-1302-8:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-146b Adenovirus Infection 20634878 miR-146b:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-150 Adenovirus Infection 20634878 miR-150:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-17 Adenovirus Infection 20634878 miR-17:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-18a Adenovirus Infection 20634878 miR-18a:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-191 Adenovirus Infection 20634878 miR-191:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-1972-1 Adenovirus Infection 20634878 miR-1972:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-320c-2 Adenovirus Infection 20634878 miR-320c-2:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-324 Adenovirus Infection 20634878 miR-324:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-342 Adenovirus Infection 20634878 miR-342:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-345 Adenovirus Infection 20634878 miR-345:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-378a Adenovirus Infection 20634878 miR-378:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-454 Adenovirus Infection 20634878 miR-454:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-505 Adenovirus Infection 20634878 miR-505:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-566 Adenovirus Infection 20634878 miR-566:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-589 Adenovirus Infection 20634878 miR-589:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-627 Adenovirus Infection 20634878 miR-627:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-635 Adenovirus Infection 20634878 miR-635:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-7-1 Adenovirus Infection 20634878 miR-7-1:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-7-2 Adenovirus Infection 20634878 miR-7-2:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-7-3 Adenovirus Infection 20634878 miR-7-3:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-744 Adenovirus Infection 20634878 miR-744:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-92a-1 Adenovirus Infection 20634878 miR-92a-1:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-942 Adenovirus Infection 20634878 miR-942:A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control -tissue_expression_up hsa-mir-33 Squamous Cell Carcinoma 20652977 "The miRNAs miR-363, miR-33, and miR-497 were upregulated, whereas miR-155, miR-181a, miR-181b, miR-29a, miR-218, miR-222, miR-221, and miR-142-5p were downregulated in HPV-positive cells compared to both HPV-negative SCCHN and normal oral keratinocytes." -tissue_expression_up hsa-mir-363 Squamous Cell Carcinoma 20652977 "The miRNAs miR-363, miR-33, and miR-497 were upregulated, whereas miR-155, miR-181a, miR-181b, miR-29a, miR-218, miR-222, miR-221, and miR-142-5p were downregulated in HPV-positive cells compared to both HPV-negative SCCHN and normal oral keratinocytes." -tissue_expression_up hsa-mir-497 Squamous Cell Carcinoma 20652977 "The miRNAs miR-363, miR-33, and miR-497 were upregulated, whereas miR-155, miR-181a, miR-181b, miR-29a, miR-218, miR-222, miR-221, and miR-142-5p were downregulated in HPV-positive cells compared to both HPV-negative SCCHN and normal oral keratinocytes." -tissue_expression_up hsa-mir-17 Pancreatic Neoplasms 20703102 "MicroRNA miR-17-5p is overexpressed in pancreatic cancer, associated with a poor prognosis, and involved in cancer cell proliferation and invasion" -tissue_expression_up hsa-mir-21 Astrocytoma 20711171 Inhibition of two glioblastoma-upregulated miRNAs (miR-21 and miR-23a) and exogenous overexpression of two glioblastoma-downregulated miRNAs (miR-218 and miR-219-5p) resulted in reduced soft agar colony formation but showed varying effects on cell proliferation and chemosensitivity. -tissue_expression_up hsa-mir-23a Astrocytoma 20711171 Inhibition of two glioblastoma-upregulated miRNAs (miR-21 and miR-23a) and exogenous overexpression of two glioblastoma-downregulated miRNAs (miR-218 and miR-219-5p) resulted in reduced soft agar colony formation but showed varying effects on cell proliferation and chemosensitivity. -tissue_expression_up hsa-let-7f Ovarian Neoplasms 20716115 "Reduced miR-145 and miR-214 and elevated let-7f, miR-182, miR-210, miR-200c, miR-222 and miR-23a levels were found in effusions in both sets." -tissue_expression_up hsa-mir-182 Ovarian Neoplasms 20716115 "Reduced miR-145 and miR-214 and elevated let-7f, miR-182, miR-210, miR-200c, miR-222 and miR-23a levels were found in effusions in both sets." -tissue_expression_up hsa-mir-200c Ovarian Neoplasms 20716115 "Reduced miR-145 and miR-214 and elevated let-7f, miR-182, miR-210, miR-200c, miR-222 and miR-23a levels were found in effusions in both sets." -tissue_expression_up hsa-mir-210 Ovarian Neoplasms 20716115 "Reduced miR-145 and miR-214 and elevated let-7f, miR-182, miR-210, miR-200c, miR-222 and miR-23a levels were found in effusions in both sets." -tissue_expression_up hsa-mir-222 Ovarian Neoplasms 20716115 "Reduced miR-145 and miR-214 and elevated let-7f, miR-182, miR-210, miR-200c, miR-222 and miR-23a levels were found in effusions in both sets." -tissue_expression_up hsa-mir-23a Ovarian Neoplasms 20716115 "Reduced miR-145 and miR-214 and elevated let-7f, miR-182, miR-210, miR-200c, miR-222 and miR-23a levels were found in effusions in both sets." -tissue_expression_up hsa-mir-106a Breast Neoplasms 20801493 "A high correlation of miRNA expression level was found between breast tumor tissues and sera. MiR-21, miR-106a and miR-155 were significantly over-expressed in the tumor specimens compared with those in normal controls (P < 0.05), whereas miR-126, miR-199a and miR-335 were significantly under-expressed (P < 0.05)." -tissue_expression_up hsa-mir-155 Breast Neoplasms 20801493 "A high correlation of miRNA expression level was found between breast tumor tissues and sera. MiR-21, miR-106a and miR-155 were significantly over-expressed in the tumor specimens compared with those in normal controls (P < 0.05), whereas miR-126, miR-199a and miR-335 were significantly under-expressed (P < 0.05)." -tissue_expression_up hsa-mir-21 Breast Neoplasms 20801493 "A high correlation of miRNA expression level was found between breast tumor tissues and sera. MiR-21, miR-106a and miR-155 were significantly over-expressed in the tumor specimens compared with those in normal controls (P < 0.05), whereas miR-126, miR-199a and miR-335 were significantly under-expressed (P < 0.05)." -tissue_expression_up hsa-mir-223 Gastrointestinal Neoplasms 20802470 "Taken together, aberrant E2A expression is a diagnostic feature of a subtype of gastric MALT lymphoma with weaker plasmacytoid infiltrates and stronger miR-223 expression." -tissue_expression_up hsa-mir-20b Laryngeal Neoplasms 20806854 upregulated by 3 multiple -tissue_expression_up hsa-mir-31 Laryngeal Neoplasms 20806854 upregulated by 3 multiple -tissue_expression_up hsa-mir-93 Laryngeal Neoplasms 20806854 upregulated by 3 multiple -tissue_expression_up hsa-let-7a-1 Spinal Cord Injuries 20816819 Let-7a:SCI results in increased expression of miR Let-7a and miR16 -tissue_expression_up hsa-let-7a-2 Spinal Cord Injuries 20816819 Let-7a:SCI results in increased expression of miR Let-7a and miR16 -tissue_expression_up hsa-let-7a-3 Spinal Cord Injuries 20816819 Let-7a:SCI results in increased expression of miR Let-7a and miR16 -tissue_expression_up hsa-mir-15b Spinal Cord Injuries 20816819 "spinal cord injury (SCI)results in increased expression of miR Let-7a and miR16 while exercise leads to elevated levels of miR21 and decreased levels of miR15b. These changes in miR expression are correlated with changes in expression of their target genes: pro-apoptotic (decreased PTEN, PDCD4, and RAS mRNA) and anti-apoptotic (increased Bcl-2 mRNA) target genes. This is accompanied by a down-regulation of mRNA for caspase-7 and caspase-9 and reduced levels of caspase-7 protein." -tissue_expression_up hsa-mir-16-1 Spinal Cord Injuries 20816819 miR16:SCI results in increased expression of miR Let-7a and miR16 -tissue_expression_up hsa-mir-16-2 Spinal Cord Injuries 20816819 miR16:SCI results in increased expression of miR Let-7a and miR16 -tissue_expression_up hsa-mir-192 Neoplasms [unspecific] 20864637 "miR-192:Hsa-miR-193-3p was overexpressed in MPM, while hsa-miR-200c and hsa-miR-192 were overexpressed in peripheral lung adenocarcinoma and carcinomas" -tissue_expression_up hsa-mir-193a Mesothelioma 20864637 "miR-193-3p:Hsa-miR-193-3p was overexpressed in MPM, while hsa-miR-200c and hsa-miR-192 were overexpressed in peripheral lung adenocarcinoma and carcinomas" -tissue_expression_up hsa-mir-200c "Adenocarcinoma, Lung" 20864637 "miR-200c:Hsa-miR-193-3p was overexpressed in MPM, while hsa-miR-200c and hsa-miR-192 were overexpressed in peripheral lung adenocarcinoma and carcinomas" -tissue_expression_up hsa-mir-200a "Fatty Liver, Non-Alcoholic" 20956972 "The miRNAs analysis showed the significant downregulation of three miRNAs (miR-122, miR-451 and miR-27) and the upregulation of miR-200a, miR-200b and miR-429 in HFD, SD-HF and HFD-HF rats" -tissue_expression_up hsa-mir-200b "Fatty Liver, Non-Alcoholic" 20956972 "The miRNAs analysis showed the significant downregulation of three miRNAs (miR-122, miR-451 and miR-27) and the upregulation of miR-200a, miR-200b and miR-429 in HFD, SD-HF and HFD-HF rats" -tissue_expression_up hsa-mir-429 "Fatty Liver, Non-Alcoholic" 20956972 "The miRNAs analysis showed the significant downregulation of three miRNAs (miR-122, miR-451 and miR-27) and the upregulation of miR-200a, miR-200b and miR-429 in HFD, SD-HF and HFD-HF rats" -tissue_expression_up hsa-mir-195 Astrocytoma 20976148 The observation that miR-34a and miR-195 levels were increased in the RISC of U-87 astrocytoma cells suggests an oncogenic role for these miRNAs. -tissue_expression_up hsa-mir-34a Astrocytoma 20976148 The observation that miR-34a and miR-195 levels were increased in the RISC of U-87 astrocytoma cells suggests an oncogenic role for these miRNAs. -tissue_expression_up hsa-mir-141 "Carcinoma, Endometrioid Endometrial" 21035172 "A miRNA microarray showed that the miR-200 family, including hsa-miR-141, hsa-miR-200a, hsa-miR-200b, hsa-miR-200c, and hsa-miR-429, was up-regulated in EECs as compared with that in normal endometrial tissues." -tissue_expression_up hsa-mir-200a "Carcinoma, Endometrioid Endometrial" 21035172 "A miRNA microarray showed that the miR-200 family, including hsa-miR-141, hsa-miR-200a, hsa-miR-200b, hsa-miR-200c, and hsa-miR-429, was up-regulated in EECs as compared with that in normal endometrial tissues." -tissue_expression_up hsa-mir-200b "Carcinoma, Endometrioid Endometrial" 21035172 "A miRNA microarray showed that the miR-200 family, including hsa-miR-141, hsa-miR-200a, hsa-miR-200b, hsa-miR-200c, and hsa-miR-429, was up-regulated in EECs as compared with that in normal endometrial tissues." -tissue_expression_up hsa-mir-200c "Carcinoma, Endometrioid Endometrial" 21035172 "A miRNA microarray showed that the miR-200 family, including hsa-miR-141, hsa-miR-200a, hsa-miR-200b, hsa-miR-200c, and hsa-miR-429, was up-regulated in EECs as compared with that in normal endometrial tissues." -tissue_expression_up hsa-mir-429 "Carcinoma, Endometrioid Endometrial" 21035172 "These results indicate that the miR-200 family is highly expressed in EECs compared with that of normal endometrial tissues and could play an important role in cancer growth. Specifically, anti-miR-429 could enhance the cytotoxic activity with cisplatin in EECs." -tissue_expression_up hsa-mir-196a "Niemann-Pick Disease, Type C" 21075073 "We found that three miRNAs, miR-196a, miR-196b and miR-296 were up-regulated (>3.5-fold increase, p<0.05) whereas 38 miRNAs were significantly down-regulated in NPC cells (>3.5-fold decrease, p<0.05)." -tissue_expression_up hsa-mir-196b "Niemann-Pick Disease, Type C" 21075073 "We found that three miRNAs, miR-196a, miR-196b and miR-296 were up-regulated (>3.5-fold increase, p<0.05) whereas 38 miRNAs were significantly down-regulated in NPC cells (>3.5-fold decrease, p<0.05)." -tissue_expression_up hsa-mir-296 "Niemann-Pick Disease, Type C" 21075073 "We found that three miRNAs, miR-196a, miR-196b and miR-296 were up-regulated (>3.5-fold increase, p<0.05) whereas 38 miRNAs were significantly down-regulated in NPC cells (>3.5-fold decrease, p<0.05)." -tissue_expression_up hsa-mir-192 Gastric Neoplasms 21119604 MicroRNA-192 and -215 are upregulated in human gastric cancer in vivo and suppress ALCAM expression in vitro. -tissue_expression_up hsa-mir-215 Gastric Neoplasms 21119604 MicroRNA-192 and -215 are upregulated in human gastric cancer in vivo and suppress ALCAM expression in vitro. -tissue_expression_up hsa-mir-155 "Carcinoma, Endometrial" 21125666 "Up-regulated miRNAs included miR-155, miR-369-5p, miR-370, miR-450a and miR-542-5p. These data suggest that in human ECS, the interplay between transcriptional repressors of E-cadherin and miRNAs provides a link between EMT-activation and the maintenance of stemness." -tissue_expression_up hsa-mir-369 "Carcinoma, Endometrial" 21125666 "Up-regulated miRNAs included miR-155, miR-369-5p, miR-370, miR-450a and miR-542-5p. These data suggest that in human ECS, the interplay between transcriptional repressors of E-cadherin and miRNAs provides a link between EMT-activation and the maintenance of stemness." -tissue_expression_up hsa-mir-450a "Carcinoma, Endometrial" 21125666 "Up-regulated miRNAs included miR-155, miR-369-5p, miR-370, miR-450a and miR-542-5p. These data suggest that in human ECS, the interplay between transcriptional repressors of E-cadherin and miRNAs provides a link between EMT-activation and the maintenance of stemness." -tissue_expression_up hsa-mir-542 "Carcinoma, Endometrial" 21125666 "Up-regulated miRNAs included miR-155, miR-369-5p, miR-370, miR-450a and miR-542-5p. These data suggest that in human ECS, the interplay between transcriptional repressors of E-cadherin and miRNAs provides a link between EMT-activation and the maintenance of stemness." -tissue_expression_up hsa-mir-34a Myelodysplastic Syndromes 21150891 "In early MDS, we monitored upregulation of proapoptotic miR-34a" -tissue_expression_up hsa-mir-7-1 Neurilemmoma 21156648 miRNA-7 attenuation in schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways. -tissue_expression_up hsa-mir-7-2 Neurilemmoma 21156648 miRNA-7 attenuation in schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways. -tissue_expression_up hsa-mir-7-3 Neurilemmoma 21156648 miRNA-7 attenuation in schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways. -tissue_expression_up hsa-mir-1-1 Myotonic Muscular Dystrophy 21169019 "We found that miR-1 and miR-335 were up-regulated, whereas miR-29b and c, and miR-33 were down-regulated in DM1 biopsies compared to controls." -tissue_expression_up hsa-mir-335 Myotonic Muscular Dystrophy 21169019 "We found that miR-1 and miR-335 were up-regulated, whereas miR-29b and c, and miR-33 were down-regulated in DM1 biopsies compared to controls." -tissue_expression_up hsa-mir-1179 Colorectal Carcinoma 21174058 "miR-150*, miR-125b-2*, miR-1179 and miR-139-3p were up-regulated in colorectal cancers with liver metastasis" -tissue_expression_up hsa-mir-125b-2 Colorectal Carcinoma 21174058 "miR-150*, miR-125b-2*, miR-1179 and miR-139-3p were up-regulated in colorectal cancers with liver metastasis" -tissue_expression_up hsa-mir-139 Colorectal Carcinoma 21174058 "miR-150*, miR-125b-2*, miR-1179 and miR-139-3p were up-regulated in colorectal cancers with liver metastasis" -tissue_expression_up hsa-mir-150 Colorectal Carcinoma 21174058 "miR-150*, miR-125b-2*, miR-1179 and miR-139-3p were up-regulated in colorectal cancers with liver metastasis" -tissue_expression_up hsa-mir-210 Liver Neoplasms 21175813 upregulated after arsenic trioxide treatment in HepG-2 cells -tissue_expression_up hsa-mir-24-1 Liver Neoplasms 21175813 upregulated after arsenic trioxide treatment in HepG-2 cells -tissue_expression_up hsa-mir-24-2 Liver Neoplasms 21175813 upregulated after arsenic trioxide treatment in HepG-2 cells -tissue_expression_up hsa-mir-29a Liver Neoplasms 21175813 "upregulated after arsenic trioxide treatment in HepG-2 cells miR-29a showed a positive therapeutic effect in liver cancer cells by inhibiting cell growth and inducing cell apoptosis, and PPM1D was confirmed to be the target gene of miR-29a." -tissue_expression_up hsa-mir-30a Liver Neoplasms 21175813 upregulated after arsenic trioxide treatment in HepG-2 cells -tissue_expression_up hsa-mir-10b Liver Neoplasms 21176238 overexpressed in side population of HCC cells compared to fetal liver cells -tissue_expression_up hsa-mir-21 Liver Neoplasms 21176238 overexpressed in side population of HCC cells compared to fetal liver cells -tissue_expression_up hsa-mir-34c Liver Neoplasms 21176238 miR-34c-3p is overexpressed in side population of HCC cells compared to fetal liver cells -tissue_expression_up hsa-mir-183 Ovarian Neoplasms 21176563 "Increased expression of miR-183 and miR-22 may both repress the protein level of ezrin, indicating that miR-183 and miR-22 may bear a potential role in inhibiting ovarian cancer metastasis in a ezrin-mediated way" -tissue_expression_up hsa-mir-22 Ovarian Neoplasms 21176563 "Increased expression of miR-183 and miR-22 may both repress the protein level of ezrin, indicating that miR-183 and miR-22 may bear a potential role in inhibiting ovarian cancer metastasis in a ezrin-mediated way" -tissue_expression_up hsa-mir-330 Prostate Neoplasms 21177307 "We also observed a significant down-regulation of androgen-regulated miRNA-21 and up-regulation of a tumor suppressor, miRNA-330, in tumors of mice treated with EGCG" -tissue_expression_up hsa-let-7e Synovial Sarcoma 21213367 upregulated -tissue_expression_up hsa-mir-125a Synovial Sarcoma 21213367 hsa-mir-125a-3p upregulated -tissue_expression_up hsa-mir-99b Synovial Sarcoma 21213367 upregulated -tissue_expression_up hsa-mir-29b-1 Urinary Bladder Cancer 21223810 "In grade I, grade II, grade III, grade I + II + III, infiltrating and non-infiltrating groups, hsa-miR-29b-1* was up-regulated while hsa-miR-923 and hsa-miR-300 were down-regulated" -tissue_expression_up hsa-mir-129-1 "Squamous Cell Carcinoma, Oral" 21244772 "Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours." -tissue_expression_up hsa-mir-129-2 "Squamous Cell Carcinoma, Oral" 21244772 "Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours." -tissue_expression_up hsa-mir-146b "Squamous Cell Carcinoma, Oral" 21244772 "Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours." -tissue_expression_up hsa-mir-21 "Squamous Cell Carcinoma, Oral" 21244772 "Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours." -tissue_expression_up hsa-mir-210 "Squamous Cell Carcinoma, Oral" 21244772 "Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours." -tissue_expression_up hsa-mir-212 "Squamous Cell Carcinoma, Oral" 21244772 "Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours." -tissue_expression_up hsa-mir-214 "Squamous Cell Carcinoma, Oral" 21244772 "Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours." -tissue_expression_up hsa-mir-23a "Squamous Cell Carcinoma, Oral" 21244772 "Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours." -tissue_expression_up hsa-mir-23b "Squamous Cell Carcinoma, Oral" 21244772 "Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours." -tissue_expression_up hsa-mir-25 "Squamous Cell Carcinoma, Oral" 21244772 "Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours." -tissue_expression_up hsa-mir-338 "Squamous Cell Carcinoma, Oral" 21244772 "Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours." -tissue_expression_up hsa-mir-489 "Squamous Cell Carcinoma, Oral" 21244772 "Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours." -tissue_expression_up hsa-mir-515-1 "Squamous Cell Carcinoma, Oral" 21244772 "Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours." -tissue_expression_up hsa-mir-515-2 "Squamous Cell Carcinoma, Oral" 21244772 "Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours." -tissue_expression_up hsa-mir-92a-1 "Squamous Cell Carcinoma, Oral" 21244772 "Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours." -tissue_expression_up hsa-mir-92a-2 "Squamous Cell Carcinoma, Oral" 21244772 "Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours." -tissue_expression_up hsa-mir-92b "Squamous Cell Carcinoma, Oral" 21244772 "Thirteen miRNA were significantly overexpressed (miR-489, miR-129, miR-23a, miR-214, miR-23b, miR-92, miR-25, miR-210, miR-212, miR-515, miR-146b, miR-21, miR-338) and 6 miRNA were underexpressed (miR-520h, miR-197, miR-378, miR-135b, miR-224, miR-34a) in oral tumours. Underexpression of mir-155, let-7i, mir-146a was found to characterize progression to metastastatic tumours." -tissue_expression_up hsa-let-7c Prostate Neoplasms 21255804 "Using the Cox regression test the risk of recurrence was 3.0, 3.3, 2.7 and 3.4 for high levels of miR-100, miR-145, miR-191 and miR-let7c, respectively." -tissue_expression_up hsa-mir-100 Prostate Neoplasms 21255804 "Using the Cox regression test the risk of recurrence was 3.0, 3.3, 2.7 and 3.4 for high levels of miR-100, miR-145, miR-191 and miR-let7c, respectively." -tissue_expression_up hsa-mir-145 Prostate Neoplasms 21255804 "Using the Cox regression test the risk of recurrence was 3.0, 3.3, 2.7 and 3.4 for high levels of miR-100, miR-145, miR-191 and miR-let7c, respectively." -tissue_expression_up hsa-mir-191 Prostate Neoplasms 21255804 "Using the Cox regression test the risk of recurrence was 3.0, 3.3, 2.7 and 3.4 for high levels of miR-100, miR-145, miR-191 and miR-let7c, respectively." -tissue_expression_up hsa-mir-495 Breast Neoplasms 21258409 "miR-495 is upregulated by E12/E47 in breast cancer stem cells, and promotes oncogenesis and hypoxia resistance via downregulation of E-cadherin and REDD1." -tissue_expression_up hsa-mir-126 "Carcinoma, Lung, Non-Small-Cell" 21264844 Independent and tissue-specific prognostic impact of miR-126 in nonsmall cell lung cancer: Coexpression with vascular endothelial growth factor-A predicts poor survival. -tissue_expression_up hsa-mir-126 Esophageal Neoplasms 21269950 hsa-mir-126 is upregulated and hsa-miR-518b is downregulated in esophageal squamous carcinoma -tissue_expression_up hsa-mir-21 Breast Neoplasms 21270527 "miR-21, miR-210 and miR-221 were significantly overexpressed, whereas miR-10b, miR-145, miR-205, miR-122a were significantly underexpressed in the triple-negative primary breast cancers." -tissue_expression_up hsa-mir-210 Breast Neoplasms 21270527 "miR-21, miR-210 and miR-221 were significantly overexpressed, whereas miR-10b, miR-145, miR-205, miR-122a were significantly underexpressed in the triple-negative primary breast cancers." -tissue_expression_up hsa-mir-221 Breast Neoplasms 21270527 "miR-21, miR-210 and miR-221 were significantly overexpressed, whereas miR-10b, miR-145, miR-205, miR-122a were significantly underexpressed in the triple-negative primary breast cancers." -tissue_expression_up hsa-mir-181a-2 Breast Neoplasms 21271219 Increased miR-21 and miR-181a levels were significantly associated with shortened -tissue_expression_up hsa-mir-21 Breast Neoplasms 21271219 "Increased miR-21 and miR-181a levels were significantly associated with shortened disease-free survival(DFS; p=0.0003, 0.0007) and overall survival (OS; p=0.0351, 0.0443), respectively. Accumulation of miR-21 and miR-181a in bone marrow appears to be associated with prognosis in breast cancer patients. The much higher significant correlation with microRNA levels and prognosis suggests epistatic effects on multiple target genes in the bone marrow of breast cancer patients." -tissue_expression_up hsa-mir-373 Breast Neoplasms 21271679 miR-373 was found to be capable of promoting breast cancer invasion and metastasis -tissue_expression_up hsa-mir-221 Thyroid Neoplasms 21275764 mir-221 was overexpressed in 19 patients (p<0.0001) with a sensitive yield of 95%. -tissue_expression_up hsa-mir-638 Lung Neoplasms 21303527 We found the upregulation of microRNA-638 and microRNA-923 in bostrycin-treated lung adenocarcinoma cells -tissue_expression_up hsa-let-7b Preeclampsia 21309633 "Six miRNAs were more than 2-fold over-expressed in severe preeclampsia: let-7b, miRNA-302*, miRNA-104, miRNA-128a, miRNA-182* and miRNA-133b." -tissue_expression_up hsa-mir-128-1 Preeclampsia 21309633 "Six miRNAs were more than 2-fold over-expressed in severe preeclampsia: let-7b, miRNA-302*, miRNA-104, miRNA-128a, miRNA-182* and miRNA-133b." -tissue_expression_up hsa-mir-128-2 Preeclampsia 21309633 "Six miRNAs were more than 2-fold over-expressed in severe preeclampsia: let-7b, miRNA-302*, miRNA-104, miRNA-128a, miRNA-182* and miRNA-133b." -tissue_expression_up hsa-mir-133b Preeclampsia 21309633 "Six miRNAs were more than 2-fold over-expressed in severe preeclampsia: let-7b, miRNA-302*, miRNA-104, miRNA-128a, miRNA-182* and miRNA-133b." -tissue_expression_up hsa-mir-182 Preeclampsia 21309633 "Six miRNAs were more than 2-fold over-expressed in severe preeclampsia: let-7b, miRNA-302*, miRNA-104, miRNA-128a, miRNA-182* and miRNA-133b." -tissue_expression_up hsa-mir-21 Preeclampsia 21309633 "Six miRNAs were more than 2-fold over-expressed in severe preeclampsia: let-7b, miRNA-302*, miRNA-104, miRNA-128a, miRNA-182* and miRNA-133b." -tissue_expression_up hsa-mir-302a Preeclampsia 21309633 "Six miRNAs were more than 2-fold over-expressed in severe preeclampsia: let-7b, miRNA-302*, miRNA-104, miRNA-128a, miRNA-182* and miRNA-133b." -tissue_expression_up hsa-mir-302b Preeclampsia 21309633 "Six miRNAs were more than 2-fold over-expressed in severe preeclampsia: let-7b, miRNA-302*, miRNA-104, miRNA-128a, miRNA-182* and miRNA-133b." -tissue_expression_up hsa-mir-302c Preeclampsia 21309633 "Six miRNAs were more than 2-fold over-expressed in severe preeclampsia: let-7b, miRNA-302*, miRNA-104, miRNA-128a, miRNA-182* and miRNA-133b." -tissue_expression_up hsa-mir-302d Preeclampsia 21309633 "Six miRNAs were more than 2-fold over-expressed in severe preeclampsia: let-7b, miRNA-302*, miRNA-104, miRNA-128a, miRNA-182* and miRNA-133b." -tissue_expression_up hsa-mir-302e Preeclampsia 21309633 "Six miRNAs were more than 2-fold over-expressed in severe preeclampsia: let-7b, miRNA-302*, miRNA-104, miRNA-128a, miRNA-182* and miRNA-133b." -tissue_expression_up hsa-mir-302f Preeclampsia 21309633 "Six miRNAs were more than 2-fold over-expressed in severe preeclampsia: let-7b, miRNA-302*, miRNA-104, miRNA-128a, miRNA-182* and miRNA-133b." -tissue_expression_up hsa-mir-17 Mesothelioma 21317924 Hsa-miR-17* was significantly upregulated and hsa-miR-30c was significantly downregulated by Onconase treatment in all cell lines -tissue_expression_up hsa-mir-492 Hepatoblastoma 21319197 MicroRNA-492 is processed from the keratin 19 gene and up-regulated in metastatic hepatoblastoma. -tissue_expression_up hsa-mir-151a "Carcinoma, Hepatocellular" 21319996 miR-30d and miR-151 were amplified in ~50% of Hepatitis B Virus-Associated HCC tumor tissues -tissue_expression_up hsa-mir-30d "Carcinoma, Hepatocellular" 21319996 miR-30d and miR-151 were amplified in ~50% of Hepatitis B Virus-Associated HCC tumor tissues -tissue_expression_up hsa-mir-21 Breast Neoplasms 21326627 miR-21 Expression in Pregnancy-Associated Breast Cancer: A Possible Marker of Poor Prognosis. -tissue_expression_up hsa-mir-21 Endometrial Neoplasms 21330826 Highly increased maspin expression corresponds with up-regulation of miR-21 in endometrial cancer -tissue_expression_up hsa-mir-142 Gastric Neoplasms 21343377 A high frequency recurrence and poor survival were observed in gastric cancer cases with high level of hsa-miR-375 and low level of hsa-miR-142-5p (P < 0.001). The results indicate that the combination of hsa-miR-375 and hsa-miR-142-5p as a predictor of disease progression has the potential to predict recurrence risk for GC patients. -tissue_expression_up hsa-mir-142 Gastrointestinal Neoplasms 21343377 "A high frequency recurrence and poor survival were observed in GC cases with high level of hsa-miR-375 and low level of hsa-miR-142-5p (P < 0.001),indicating that the combination of hsa-miR-375 and hsa-miR-142-5p as a predictor of disease progression has the potential to predict recurrence risk for GC patients" -tissue_expression_up hsa-mir-375 Gastric Neoplasms 21343377 A high frequency recurrence and poor survival were observed in gastric cancer cases with high level of hsa-miR-375 and low level of hsa-miR-142-5p (P < 0.001). The results indicate that the combination of hsa-miR-375 and hsa-miR-142-5p as a predictor of disease progression has the potential to predict recurrence risk for GC patients. -tissue_expression_up hsa-mir-375 Gastrointestinal Neoplasms 21343377 "A high frequency recurrence and poor survival were observed in GC cases with high level of hsa-miR-375 and low level of hsa-miR-142-5p (P < 0.001),indicating that the combination of hsa-miR-375 and hsa-miR-142-5p as a predictor of disease progression has the potential to predict recurrence risk for GC patients" -tissue_expression_up hsa-mir-142 Pancreatic Neoplasms 21347785 patients with high miR-142-5p and miR-204 expression had significantly longer survival times than those with low miR-142-5p (P = 0.0077) and miR-204 (P = 0.0054) expression in the gemcitabine-treated group. -tissue_expression_up hsa-mir-204 Pancreatic Neoplasms 21347785 patients with high miR-142-5p and miR-204 expression had significantly longer survival times than those with low miR-142-5p (P = 0.0077) and miR-204 (P = 0.0054) expression in the gemcitabine-treated group. -tissue_expression_up hsa-mir-106a Mesothelioma 21358347 "miR 17-5p, 18a, 19b, 20a, 20b, 25, 92, 106a, 106b, were markedly upregulated" -tissue_expression_up hsa-mir-106b Mesothelioma 21358347 "miR 17-5p, 18a, 19b, 20a, 20b, 25, 92, 106a, 106b, were markedly upregulated" -tissue_expression_up hsa-mir-17 Mesothelioma 21358347 "miR 17-5p, 18a, 19b, 20a, 20b, 25, 92, 106a, 106b, were markedly upregulated" -tissue_expression_up hsa-mir-18a Mesothelioma 21358347 "miR 17-5p, 18a, 19b, 20a, 20b, 25, 92, 106a, 106b, were markedly upregulated" -tissue_expression_up hsa-mir-19b-1 Mesothelioma 21358347 "miR 17-5p, 18a, 19b, 20a, 20b, 25, 92, 106a, 106b, were markedly upregulated" -tissue_expression_up hsa-mir-19b-2 Mesothelioma 21358347 "miR 17-5p, 18a, 19b, 20a, 20b, 25, 92, 106a, 106b, were markedly upregulated" -tissue_expression_up hsa-mir-20a Mesothelioma 21358347 "miR 17-5p, 18a, 19b, 20a, 20b, 25, 92, 106a, 106b, were markedly upregulated" -tissue_expression_up hsa-mir-20b Mesothelioma 21358347 "miR 17-5p, 18a, 19b, 20a, 20b, 25, 92, 106a, 106b, were markedly upregulated" -tissue_expression_up hsa-mir-25 Mesothelioma 21358347 "miR 17-5p, 18a, 19b, 20a, 20b, 25, 92, 106a, 106b, were markedly upregulated" -tissue_expression_up hsa-mir-92a-1 Mesothelioma 21358347 "miR 17-5p, 18a, 19b, 20a, 20b, 25, 92, 106a, 106b, were markedly upregulated" -tissue_expression_up hsa-mir-92a-2 Mesothelioma 21358347 "miR 17-5p, 18a, 19b, 20a, 20b, 25, 92, 106a, 106b, were markedly upregulated" -tissue_expression_up hsa-mir-125b Psoriasis 21373745 "Real-time PCR and immunohistochemistry showed that p63 expression was not significantly affected, whereas NB-UVB phototherapy significantly decreased expression ofmiR-21 (p = 0.003) and increased miR-125b levels (p = 0.003). The results indicate that the unresolved p63 abnormality in treated epidermis may play a role in maintenance of this disease." -tissue_expression_up hsa-mir-125a Retinoblastoma 21373755 "We identified a cluster of miRNAs that includes miR-181b, miR-125a-3p, miR-30c-2, miR-497 and miR-491-3p as hypoxia-regulated miRNAs (HRMs) in retinoblastoma cells, of which miR-181b was the most typically differentially expressed miRNA under hypoxic conditions." -tissue_expression_up hsa-mir-181b-1 Retinoblastoma 21373755 "We identified a cluster of miRNAs that includes miR-181b, miR-125a-3p, miR-30c-2, miR-497 and miR-491-3p as hypoxia-regulated miRNAs (HRMs) in retinoblastoma cells, of which miR-181b was the most typically differentially expressed miRNA under hypoxic conditions." -tissue_expression_up hsa-mir-181b-2 Retinoblastoma 21373755 "We identified a cluster of miRNAs that includes miR-181b, miR-125a-3p, miR-30c-2, miR-497 and miR-491-3p as hypoxia-regulated miRNAs (HRMs) in retinoblastoma cells, of which miR-181b was the most typically differentially expressed miRNA under hypoxic conditions." -tissue_expression_up hsa-mir-30c-2 Retinoblastoma 21373755 "We identified a cluster of miRNAs that includes miR-181b, miR-125a-3p, miR-30c-2, miR-497 and miR-491-3p as hypoxia-regulated miRNAs (HRMs) in retinoblastoma cells, of which miR-181b was the most typically differentially expressed miRNA under hypoxic conditions." -tissue_expression_up hsa-mir-491 Retinoblastoma 21373755 "We identified a cluster of miRNAs that includes miR-181b, miR-125a-3p, miR-30c-2, miR-497 and miR-491-3p as hypoxia-regulated miRNAs (HRMs) in retinoblastoma cells, of which miR-181b was the most typically differentially expressed miRNA under hypoxic conditions." -tissue_expression_up hsa-mir-497 Retinoblastoma 21373755 "We identified a cluster of miRNAs that includes miR-181b, miR-125a-3p, miR-30c-2, miR-497 and miR-491-3p as hypoxia-regulated miRNAs (HRMs) in retinoblastoma cells, of which miR-181b was the most typically differentially expressed miRNA under hypoxic conditions." -tissue_expression_up hsa-mir-18a Nasopharyngeal Neoplasms 21373758 overexpressed -tissue_expression_up hsa-mir-210 Preeclampsia 21388517 Elevated levels of hypoxia-inducible microRNA-210 in pre-eclampsia: new insights into molecular mechanisms for the disease. -tissue_expression_up hsa-mir-16-1 "Carcinoma, Lung, Non-Small-Cell" 21400525 miR-16 levels in tumor samples may be a prognostic marker in NSCLC. -tissue_expression_up hsa-mir-16-2 "Carcinoma, Lung, Non-Small-Cell" 21400525 miR-16 levels in tumor samples may be a prognostic marker in NSCLC. -tissue_expression_up hsa-mir-155 Mycosis Fungoides 21406335 upregulated in tumor stage MF compared to benign inflammatory dermatoses. -tissue_expression_up hsa-mir-92a-1 Mycosis Fungoides 21406335 upregulated in tumor stage MF compared to benign inflammatory dermatoses. -tissue_expression_up hsa-mir-92a-2 Mycosis Fungoides 21406335 upregulated in tumor stage MF compared to benign inflammatory dermatoses. -tissue_expression_up hsa-mir-93 Mycosis Fungoides 21406335 upregulated in tumor stage MF compared to benign inflammatory dermatoses. -tissue_expression_up hsa-mir-125b-1 Breast Neoplasms 21409395 "let7c, miR-125b, miR-126, miR-127-3p, miR-143, miR-145, miR-146b-5p, and miR-199a-3p), preferentially expressed in normal basal cells" -tissue_expression_up hsa-mir-125b-2 Breast Neoplasms 21409395 "let7c, miR-125b, miR-126, miR-127-3p, miR-143, miR-145, miR-146b-5p, and miR-199a-3p), preferentially expressed in normal basal cells" -tissue_expression_up hsa-mir-126 Breast Neoplasms 21409395 "let7c, miR-125b, miR-126, miR-127-3p, miR-143, miR-145, miR-146b-5p, and miR-199a-3p), preferentially expressed in normal basal cells" -tissue_expression_up hsa-mir-127 Breast Neoplasms 21409395 "let7c, miR-125b, miR-126, miR-127-3p, miR-143, miR-145, miR-146b-5p, and miR-199a-3p), preferentially expressed in normal basal cells" -tissue_expression_up hsa-mir-143 Breast Neoplasms 21409395 "let7c, miR-125b, miR-126, miR-127-3p, miR-143, miR-145, miR-146b-5p, and miR-199a-3p), preferentially expressed in normal basal cells" -tissue_expression_up hsa-mir-145 Breast Neoplasms 21409395 "let7c, miR-125b, miR-126, miR-127-3p, miR-143, miR-145, miR-146b-5p, and miR-199a-3p), preferentially expressed in normal basal cells" -tissue_expression_up hsa-mir-146b Breast Neoplasms 21409395 "let7c, miR-125b, miR-126, miR-127-3p, miR-143, miR-145, miR-146b-5p, and miR-199a-3p), preferentially expressed in normal basal cells" -tissue_expression_up hsa-mir-199a-1 Breast Neoplasms 21409395 "let7c, miR-125b, miR-126, miR-127-3p, miR-143, miR-145, miR-146b-5p, and miR-199a-3p), preferentially expressed in normal basal cells" -tissue_expression_up hsa-mir-199a-2 Breast Neoplasms 21409395 "let7c, miR-125b, miR-126, miR-127-3p, miR-143, miR-145, miR-146b-5p, and miR-199a-3p), preferentially expressed in normal basal cells" -tissue_expression_up hsa-mir-200c Breast Neoplasms 21409395 "Both miR-200c and miR-429, two members of the miR-200 family were expressed in the luminal and basal type of breast cancer in contrast to malignant myoepithelioma." -tissue_expression_up hsa-mir-429 Breast Neoplasms 21409395 "Both miR-200c and miR-429, two members of the miR-200 family were expressed in the luminal and basal type of breast cancer in contrast to malignant myoepithelioma." -tissue_expression_up hsa-mir-155 Colorectal Carcinoma 21412018 High miR-155 expression was significantly correlated with lymph node metastases. The overall (OS) and disease-free survival (DFS) rates of patients with high miR-155 expression were also significantly worse than those in patients with low miR-155 expression. -tissue_expression_up hsa-mir-21 Colorectal Carcinoma 21412018 "High miR-21 expression was significantly associated with venous invasion, liver metastasis and tumor stage.The overall (OS) and disease-free survival (DFS) rates of patients with high miR-21 expression were significantly worse than those of patients with low miR-21 expression." -tissue_expression_up hsa-mir-21 Obesity 21426570 mir-21 is up-regulated in subcutaneous adipose tissue in human obesity -tissue_expression_up hsa-mir-100 Endometriosis 21436257 up-regulated in endometriomas compared with endometrium. -tissue_expression_up hsa-mir-193a Endometriosis 21436257 miR-193a-3p and miR-193a-5p up-regulated in endometriomas compared with endometrium. -tissue_expression_up hsa-mir-202 Endometriosis 21436257 up-regulated in endometriomas compared with endometrium. -tissue_expression_up hsa-mir-29c Endometriosis 21436257 up-regulated in endometriomas compared with endometrium. -tissue_expression_up hsa-mir-485 Endometriosis 21436257 miR-485-3p up-regulated in endometriomas compared with endometrium. -tissue_expression_up hsa-mir-509-3 Endometriosis 21436257 miR-509-3-5p up-regulated in endometriomas compared with endometrium. -tissue_expression_up hsa-mir-574 Endometriosis 21436257 miR-574-3p up-regulated in endometriomas compared with endometrium. -tissue_expression_up hsa-mir-708 Endometriosis 21436257 up-regulated in endometriomas compared with endometrium. -tissue_expression_up hsa-mir-720 Endometriosis 21436257 up-regulated in endometriomas compared with endometrium. -tissue_expression_up hsa-mir-143 "Diabetes Mellitus, Type 2" 21441927 Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism. -tissue_expression_up hsa-mir-143 Esophageal Neoplasms 21453382 The high levels of expression of mature MIR143 and mature MIR145 were associated with recurrence of metastasis in ESCC patients.The high expression of mature MIR21 and mature MIR205 was associated with lymph node positivity in ESCC patients (P < 0.05). -tissue_expression_up hsa-mir-145 Esophageal Neoplasms 21453382 The high levels of expression of mature MIR143 and mature MIR145 were associated with recurrence of metastasis in ESCC patients.The high expression of mature MIR21 and mature MIR205 was associated with lymph node positivity in ESCC patients (P < 0.05). -tissue_expression_up hsa-mir-205 Esophageal Neoplasms 21453382 The high levels of expression of mature MIR143 and mature MIR145 were associated with recurrence of metastasis in ESCC patients.The high expression of mature MIR21 and mature MIR205 was associated with lymph node positivity in ESCC patients (P < 0.05). -tissue_expression_up hsa-mir-21 Esophageal Neoplasms 21453382 The high levels of expression of mature MIR143 and mature MIR145 were associated with recurrence of metastasis in ESCC patients.The high expression of mature MIR21 and mature MIR205 was associated with lymph node positivity in ESCC patients (P < 0.05). -tissue_expression_up hsa-mir-223 Esophageal Neoplasms 21453483 miR-223 regulates migration and invasion by targeting Artemin in human esophageal carcinoma. -tissue_expression_up hsa-mir-155 Multiple Sclerosis 21453702 Several miRNAs such as miR-155 or miR-326 are considerably overexpressed in active MS lesions versus controls -tissue_expression_up hsa-mir-326 Multiple Sclerosis 21453702 Several miRNAs such as miR-155 or miR-326 are considerably overexpressed in active MS lesions versus controls -tissue_expression_up hsa-mir-210 Sarcoma [unspecific] 21455991 Expression of microRNA 210 associates with poor survival and age of tumor onset of soft-tissue sarcoma patients. -tissue_expression_up hsa-mir-221 "Carcinoma, Hepatocellular" 21458843 Deregulated expression of microRNA-221 with the potential for prognostic biomarkers in surgically resected hepatocellular carcinoma. -tissue_expression_up hsa-mir-21 Pancreatic Neoplasms 21463919 "over-expression of Notch-1 leads to increased expression of miR-21, and decreased expression of miR-200b, miR-200c, let-7a, let-7b, and let-7c. over-expression of Notch-1 led to the induction of EMT phenotype" -tissue_expression_up hsa-mir-141 Urinary Bladder Cancer 21464941 "Compared to matched histologically normal urothelium, upregulated." -tissue_expression_up hsa-mir-17 Urinary Bladder Cancer 21464941 "Compared to matched histologically normal urothelium, upregulated." -tissue_expression_up hsa-mir-183 Urinary Bladder Cancer 21464941 "Compared to matched histologically normal urothelium, upregulated." -tissue_expression_up hsa-mir-18a Urinary Bladder Cancer 21464941 "Compared to matched histologically normal urothelium, upregulated." -tissue_expression_up hsa-mir-19a Urinary Bladder Cancer 21464941 "Compared to matched histologically normal urothelium, upregulated." -tissue_expression_up hsa-mir-19b-1 Urinary Bladder Cancer 21464941 "Compared to matched histologically normal urothelium, upregulated." -tissue_expression_up hsa-mir-19b-2 Urinary Bladder Cancer 21464941 "Compared to matched histologically normal urothelium, upregulated." -tissue_expression_up hsa-mir-200a Urinary Bladder Cancer 21464941 "Compared to matched histologically normal urothelium, upregulated." -tissue_expression_up hsa-mir-200b Urinary Bladder Cancer 21464941 "Compared to matched histologically normal urothelium, upregulated." -tissue_expression_up hsa-mir-200c Urinary Bladder Cancer 21464941 "Compared to matched histologically normal urothelium, upregulated." -tissue_expression_up hsa-mir-20a Urinary Bladder Cancer 21464941 "Compared to matched histologically normal urothelium, upregulated." -tissue_expression_up hsa-mir-429 Urinary Bladder Cancer 21464941 "Compared to matched histologically normal urothelium, upregulated." -tissue_expression_up hsa-mir-92a-1 Urinary Bladder Cancer 21464941 "Compared to matched histologically normal urothelium, upregulated." -tissue_expression_up hsa-mir-92a-2 Urinary Bladder Cancer 21464941 "Compared to matched histologically normal urothelium, upregulated." -tissue_expression_up hsa-mir-96 Urinary Bladder Cancer 21464941 "Compared to matched histologically normal urothelium, upregulated." -tissue_expression_up hsa-mir-210 "Carcinoma, Renal Cell" 21465485 "Overexpression of miR-210, a downstream target of HIF1, causes centrosome amplification in renal carcinoma cells." -tissue_expression_up hsa-mir-146a Sjogren Syndrome 21469088 Altered miR-146a expression in Sjogren's syndrome -tissue_expression_up hsa-mir-139 "Carcinoma, Adrenocortical" 21471143 "ACCs (adrenocortical carcinomas) exhibited significantly lower levels of miR-139-3p (up to 8.49-fold, p<0.001), miR-675 (up to 23.25-fold, p<0.001) and miR-335 (up to 5.25-fold, p<0.001)." -tissue_expression_up hsa-mir-375 "Carcinoma, Adrenocortical" 21471143 "ACCs (adrenocortical carcinomas) exhibited significantly lower levels of miR-139-3p (up to 8.49-fold, p<0.001), miR-675 (up to 23.25-fold, p<0.001) and miR-335 (up to 5.25-fold, p<0.001)." -tissue_expression_up hsa-mir-675 "Carcinoma, Adrenocortical" 21471143 "ACCs (adrenocortical carcinomas) exhibited significantly lower levels of miR-139-3p (up to 8.49-fold, p<0.001), miR-675 (up to 23.25-fold, p<0.001) and miR-335 (up to 5.25-fold, p<0.001)." -tissue_expression_up hsa-mir-483 "Carcinoma, Adrenocortical" 21472710 "miRs -100, -125b, and -195 were significantly down-regulated, whereas miR-483-5p was significantly up-regulated in malignant as compared with benign tumors." -tissue_expression_up hsa-mir-106a Glioblastoma 21483847 "miR-106aa upregulated in Glioblastoma vs Normal. Ten miRNAs (miR-20a, miR-106a, miR-17-5p, miR-31, miR-222, miR-148a, miR-221, miR-146b, miR-200b, and miR-193a) could be a signature predicding survival in Glioblastoma." -tissue_expression_up hsa-mir-146b Glioblastoma 21483847 "miR-146b upregulated in Glioblastoma vs Normal. Ten miRNAs (miR-20a, miR-106a, miR-17-5p, miR-31, miR-222, miR-148a, miR-221, miR-146b, miR-200b, and miR-193a) could be a signature predicding survival in Glioblastoma." -tissue_expression_up hsa-mir-148a Glioblastoma 21483847 "miR-148a upregulated in Glioblastoma vs Normal. Ten miRNAs (miR-20a, miR-106a, miR-17-5p, miR-31, miR-222, miR-148a, miR-221, miR-146b, miR-200b, and miR-193a) could be a signature predicding survival in Glioblastoma." -tissue_expression_up hsa-mir-17 Glioblastoma 21483847 "miR-17-5p upregulated in Glioblastoma vs Normal. Ten miRNAs (miR-20a, miR-106a, miR-17-5p, miR-31, miR-222, miR-148a, miR-221, miR-146b, miR-200b, and miR-193a) could be a signature predicding survival in Glioblastoma." -tissue_expression_up hsa-mir-193a Glioblastoma 21483847 "miR-193a upregulated in Glioblastoma vs Normal. Ten miRNAs (miR-20a, miR-106a, miR-17-5p, miR-31, miR-222, miR-148a, miR-221, miR-146b, miR-200b, and miR-193a) could be a signature predicding survival in Glioblastoma." -tissue_expression_up hsa-mir-200b Glioblastoma 21483847 "miR-200b upregulated in Glioblastoma vs Normal. Ten miRNAs (miR-20a, miR-106a, miR-17-5p, miR-31, miR-222, miR-148a, miR-221, miR-146b, miR-200b, and miR-193a) could be a signature predicding survival in Glioblastoma." -tissue_expression_up hsa-mir-106a Melanoma 21509659 significantly up-regulated in uveal melanomas compared with normal uveal tissues -tissue_expression_up hsa-mir-17 Melanoma 21509659 significantly up-regulated in uveal melanomas compared with normal uveal tissues -tissue_expression_up hsa-mir-20a Melanoma 21509659 significantly up-regulated in uveal melanomas compared with normal uveal tissues -tissue_expression_up hsa-mir-21 Melanoma 21509659 significantly up-regulated in uveal melanomas compared with normal uveal tissues -tissue_expression_up hsa-mir-34a Melanoma 21509659 significantly up-regulated in uveal melanomas compared with normal uveal tissues -tissue_expression_up hsa-mir-21 Sezary Disease 21525938 "MicroRNA profiling reveals that miR-21, miR-486 and miR-214 are upregulated and involved in cell survival in Sezary Syndrome." -tissue_expression_up hsa-mir-214 Sezary Disease 21525938 "MicroRNA profiling reveals that miR-21, miR-486 and miR-214 are upregulated and involved in cell survival in Sezary Syndrome." -tissue_expression_up hsa-mir-486 Sezary Disease 21525938 "MicroRNA profiling reveals that miR-21, miR-486 and miR-214 are upregulated and involved in cell survival in Sezary Syndrome." -tissue_expression_up hsa-mir-146b Thyroid Neoplasms 21537871 "miR-146b, miR-221, miR-222, miR-155, miR-31 upregulation and miR-1, miR-34b, miR-130b, miR-138 downregulation in aggressive compared with nonaggressive PTC." -tissue_expression_up hsa-mir-155 Thyroid Neoplasms 21537871 "miR-146b, miR-221, miR-222, miR-155, miR-31 upregulation and miR-1, miR-34b, miR-130b, miR-138 downregulation in aggressive compared with nonaggressive PTC." -tissue_expression_up hsa-mir-221 Thyroid Neoplasms 21537871 "miR-146b, miR-221, miR-222, miR-155, miR-31 upregulation and miR-1, miR-34b, miR-130b, miR-138 downregulation in aggressive compared with nonaggressive PTC." -tissue_expression_up hsa-mir-222 Thyroid Neoplasms 21537871 "miR-146b, miR-221, miR-222, miR-155, miR-31 upregulation and miR-1, miR-34b, miR-130b, miR-138 downregulation in aggressive compared with nonaggressive PTC." -tissue_expression_up hsa-mir-31 Thyroid Neoplasms 21537871 "miR-146b, miR-221, miR-222, miR-155, miR-31 upregulation and miR-1, miR-34b, miR-130b, miR-138 downregulation in aggressive compared with nonaggressive PTC." -tissue_expression_up hsa-mir-20a Colorectal Carcinoma 21551242 "MiR-20a and miR-31 were found to be significantly upregulated in more than one study, and miR-143 and miR-145 were found to be significantly downregulated in CRC tissue in six or more studies." -tissue_expression_up hsa-mir-31 Colorectal Carcinoma 21551242 "MiR-20a and miR-31 were found to be significantly upregulated in more than one study, and miR-143 and miR-145 were found to be significantly downregulated in CRC tissue in six or more studies." -tissue_expression_up hsa-mir-126 Thyroid Neoplasms 21553140 miR-7 and miR-126 could be candidate diagnostic microRNAs for thyroid histologic subtypes. -tissue_expression_up hsa-mir-7-1 Thyroid Neoplasms 21553140 miR-7 and miR-126 could be candidate diagnostic microRNAs for thyroid histologic subtypes. -tissue_expression_up hsa-mir-7-2 Thyroid Neoplasms 21553140 miR-7 and miR-126 could be candidate diagnostic microRNAs for thyroid histologic subtypes. -tissue_expression_up hsa-mir-7-3 Thyroid Neoplasms 21553140 miR-7 and miR-126 could be candidate diagnostic microRNAs for thyroid histologic subtypes. -tissue_expression_up hsa-mir-101-1 Head And Neck Neoplasms 21560177 "Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01)." -tissue_expression_up hsa-mir-101-1 "Squamous Cell Carcinoma, Head and Neck" 21560177 "Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01)." -tissue_expression_up hsa-mir-101-2 Head And Neck Neoplasms 21560177 "Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01)." -tissue_expression_up hsa-mir-101-2 "Squamous Cell Carcinoma, Head and Neck" 21560177 "Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01)." -tissue_expression_up hsa-mir-181b-1 Head And Neck Neoplasms 21560177 "Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01)." -tissue_expression_up hsa-mir-181b-1 "Squamous Cell Carcinoma, Head and Neck" 21560177 "Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01)." -tissue_expression_up hsa-mir-181b-2 Head And Neck Neoplasms 21560177 "Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01)." -tissue_expression_up hsa-mir-181b-2 "Squamous Cell Carcinoma, Head and Neck" 21560177 "Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01)." -tissue_expression_up hsa-mir-181d Head And Neck Neoplasms 21560177 "Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01)." -tissue_expression_up hsa-mir-181d "Squamous Cell Carcinoma, Head and Neck" 21560177 "Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01)." -tissue_expression_up hsa-mir-195 Head And Neck Neoplasms 21560177 "Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01)." -tissue_expression_up hsa-mir-195 "Squamous Cell Carcinoma, Head and Neck" 21560177 "Docetaxel resistant cells showed significant downregulation of miR-100, miR-130a, and miR-197 and upregulation in miR-101, miR-181b, miR-181d, and miR-195 expression when compared with their parent cells (p < .01)." -tissue_expression_up hsa-mir-9-1 Colorectal Carcinoma 21562850 MicroRNA-9 up-regulation is involved in colorectal cancer metastasis via promoting cell motility. -tissue_expression_up hsa-mir-9-2 Colorectal Carcinoma 21562850 MicroRNA-9 up-regulation is involved in colorectal cancer metastasis via promoting cell motility. -tissue_expression_up hsa-mir-9-3 Colorectal Carcinoma 21562850 MicroRNA-9 up-regulation is involved in colorectal cancer metastasis via promoting cell motility. -tissue_expression_up hsa-let-7d Lung Neoplasms 21563230 "Specifically, thirteen novel asbestos-related miRNAs (over-expressed: miR-148b, miR-374a, miR-24-1*, Let-7d, Let-7e, miR-199b-5p, miR-331-3p, and miR-96 and under-expressed: miR-939, miR-671-5p, miR-605, miR-1224-5p and miR-202) and inversely correlated target genes (e.g., GADD45A, LTBP1, FOSB, NCALD, CACNA2D2, MTSS1, EPB41L3) were identified. " -tissue_expression_up hsa-let-7e Lung Neoplasms 21563230 "Specifically, thirteen novel asbestos-related miRNAs (over-expressed: miR-148b, miR-374a, miR-24-1*, Let-7d, Let-7e, miR-199b-5p, miR-331-3p, and miR-96 and under-expressed: miR-939, miR-671-5p, miR-605, miR-1224-5p and miR-202) and inversely correlated target genes (e.g., GADD45A, LTBP1, FOSB, NCALD, CACNA2D2, MTSS1, EPB41L3) were identified. " -tissue_expression_up hsa-mir-148b Lung Neoplasms 21563230 "Specifically, thirteen novel asbestos-related miRNAs (over-expressed: miR-148b, miR-374a, miR-24-1*, Let-7d, Let-7e, miR-199b-5p, miR-331-3p, and miR-96 and under-expressed: miR-939, miR-671-5p, miR-605, miR-1224-5p and miR-202) and inversely correlated target genes (e.g., GADD45A, LTBP1, FOSB, NCALD, CACNA2D2, MTSS1, EPB41L3) were identified. " -tissue_expression_up hsa-mir-199b Lung Neoplasms 21563230 "Specifically, thirteen novel asbestos-related miRNAs (over-expressed: miR-148b, miR-374a, miR-24-1*, Let-7d, Let-7e, miR-199b-5p, miR-331-3p, and miR-96 and under-expressed: miR-939, miR-671-5p, miR-605, miR-1224-5p and miR-202) and inversely correlated target genes (e.g., GADD45A, LTBP1, FOSB, NCALD, CACNA2D2, MTSS1, EPB41L3) were identified. " -tissue_expression_up hsa-mir-24-1 Lung Neoplasms 21563230 "Specifically, thirteen novel asbestos-related miRNAs (over-expressed: miR-148b, miR-374a, miR-24-1*, Let-7d, Let-7e, miR-199b-5p, miR-331-3p, and miR-96 and under-expressed: miR-939, miR-671-5p, miR-605, miR-1224-5p and miR-202) and inversely correlated target genes (e.g., GADD45A, LTBP1, FOSB, NCALD, CACNA2D2, MTSS1, EPB41L3) were identified. " -tissue_expression_up hsa-mir-331 Lung Neoplasms 21563230 "Specifically, thirteen novel asbestos-related miRNAs (over-expressed: miR-148b, miR-374a, miR-24-1*, Let-7d, Let-7e, miR-199b-5p, miR-331-3p, and miR-96 and under-expressed: miR-939, miR-671-5p, miR-605, miR-1224-5p and miR-202) and inversely correlated target genes (e.g., GADD45A, LTBP1, FOSB, NCALD, CACNA2D2, MTSS1, EPB41L3) were identified. " -tissue_expression_up hsa-mir-374a Lung Neoplasms 21563230 "Specifically, thirteen novel asbestos-related miRNAs (over-expressed: miR-148b, miR-374a, miR-24-1*, Let-7d, Let-7e, miR-199b-5p, miR-331-3p, and miR-96 and under-expressed: miR-939, miR-671-5p, miR-605, miR-1224-5p and miR-202) and inversely correlated target genes (e.g., GADD45A, LTBP1, FOSB, NCALD, CACNA2D2, MTSS1, EPB41L3) were identified. " -tissue_expression_up hsa-mir-96 Lung Neoplasms 21563230 "Specifically, thirteen novel asbestos-related miRNAs (over-expressed: miR-148b, miR-374a, miR-24-1*, Let-7d, Let-7e, miR-199b-5p, miR-331-3p, and miR-96 and under-expressed: miR-939, miR-671-5p, miR-605, miR-1224-5p and miR-202) and inversely correlated target genes (e.g., GADD45A, LTBP1, FOSB, NCALD, CACNA2D2, MTSS1, EPB41L3) were identified. " -tissue_expression_up hsa-mir-34a Colorectal Carcinoma 21566225 The gene encoding the miR-34a microRNA is a transcriptional target of the p53 tumor suppressor protein and subject to epigenetic inactivation in colorectal cancer and numerous other tumor types -tissue_expression_up hsa-mir-185 Colorectal Carcinoma 21573504 "High expression of miR-185 and low expression of miR-133b were correlated with poor survival (p=0.001 and 0.028, respectively) and metastasis (p=0.007 and 0.036, respectively) in colorectal cancer." -tissue_expression_up hsa-mir-31 "Squamous Cell Carcinoma, Cerevial" 21590768 "miR-31 up-regulation in Drosha-overexpressing samples/cell lines was the highest-ranked change (by adjusted p value) in both analyses, an observation validated by northern blotting." -tissue_expression_up hsa-mir-1207 Prostate Neoplasms 21592394 "Among these miR-22, miR-29ab, miR-134, miR-1207-5p and miR-371-5p are up regulated, while miR-17 and miR-20a, members of the miR-17/92 cluster are down regulated." -tissue_expression_up hsa-mir-134 Prostate Neoplasms 21592394 "Among these miR-22, miR-29ab, miR-134, miR-1207-5p and miR-371-5p are up regulated, while miR-17 and miR-20a, members of the miR-17/92 cluster are down regulated." -tissue_expression_up hsa-mir-22 Prostate Neoplasms 21592394 "Among these miR-22, miR-29ab, miR-134, miR-1207-5p and miR-371-5p are up regulated, while miR-17 and miR-20a, members of the miR-17/92 cluster are down regulated." -tissue_expression_up hsa-mir-29a Prostate Neoplasms 21592394 "Among these miR-22, miR-29ab, miR-134, miR-1207-5p and miR-371-5p are up regulated, while miR-17 and miR-20a, members of the miR-17/92 cluster are down regulated." -tissue_expression_up hsa-mir-29b Prostate Neoplasms 21592394 "Among these miR-22, miR-29ab, miR-134, miR-1207-5p and miR-371-5p are up regulated, while miR-17 and miR-20a, members of the miR-17/92 cluster are down regulated." -tissue_expression_up hsa-mir-371 Prostate Neoplasms 21592394 "Among these miR-22, miR-29ab, miR-134, miR-1207-5p and miR-371-5p are up regulated, while miR-17 and miR-20a, members of the miR-17/92 cluster are down regulated." -tissue_expression_up hsa-mir-126 Prostate Neoplasms 21594291 "In addition, anti-invasive microRNAs such as miR-335, miR-205, miR-200, and miR-126, were up-regulated, whereas pro-invasive microRNA such as miR-21 and miR-373, were down-regulated." -tissue_expression_up hsa-mir-200 Prostate Neoplasms 21594291 "In addition, anti-invasive microRNAs such as miR-335, miR-205, miR-200, and miR-126, were up-regulated, whereas pro-invasive microRNA such as miR-21 and miR-373, were down-regulated." -tissue_expression_up hsa-mir-205 Prostate Neoplasms 21594291 "In addition, anti-invasive microRNAs such as miR-335, miR-205, miR-200, and miR-126, were up-regulated, whereas pro-invasive microRNA such as miR-21 and miR-373, were down-regulated." -tissue_expression_up hsa-mir-335 Prostate Neoplasms 21594291 "In addition, anti-invasive microRNAs such as miR-335, miR-205, miR-200, and miR-126, were up-regulated, whereas pro-invasive microRNA such as miR-21 and miR-373, were down-regulated." -tissue_expression_up hsa-mir-126 Asthma 21605405 upregulated compared with normal control -tissue_expression_up hsa-let-7b "Carcinoma, Lung, Non-Small-Cell" 21622546 "Eighteen cases were classified as AD and 13 as SCC by light microscopy and immunocytochemistry. miRNA expression profiles demonstrated considerable, statistically significant differences between AD and SCC, showing an upregulation of hsa-let-7a, hsa-let-7b, hsa-let-7c,hsa-let-7f, hsa-let-7g, hsa-let-7i, and hsa-miR-98 and a downregulation of hsa-miR-205 in AD specimens" -tissue_expression_up hsa-let-7c "Carcinoma, Lung, Non-Small-Cell" 21622546 "Eighteen cases were classified as AD and 13 as SCC by light microscopy and immunocytochemistry. miRNA expression profiles demonstrated considerable, statistically significant differences between AD and SCC, showing an upregulation of hsa-let-7a, hsa-let-7b, hsa-let-7c,hsa-let-7f, hsa-let-7g, hsa-let-7i, and hsa-miR-98 and a downregulation of hsa-miR-205 in AD specimens" -tissue_expression_up hsa-let-7f "Carcinoma, Lung, Non-Small-Cell" 21622546 "Eighteen cases were classified as AD and 13 as SCC by light microscopy and immunocytochemistry. miRNA expression profiles demonstrated considerable, statistically significant differences between AD and SCC, showing an upregulation of hsa-let-7a, hsa-let-7b, hsa-let-7c,hsa-let-7f, hsa-let-7g, hsa-let-7i, and hsa-miR-98 and a downregulation of hsa-miR-205 in AD specimens" -tissue_expression_up hsa-let-7g "Carcinoma, Lung, Non-Small-Cell" 21622546 "Eighteen cases were classified as AD and 13 as SCC by light microscopy and immunocytochemistry. miRNA expression profiles demonstrated considerable, statistically significant differences between AD and SCC, showing an upregulation of hsa-let-7a, hsa-let-7b, hsa-let-7c,hsa-let-7f, hsa-let-7g, hsa-let-7i, and hsa-miR-98 and a downregulation of hsa-miR-205 in AD specimens" -tissue_expression_up hsa-let-7i "Carcinoma, Lung, Non-Small-Cell" 21622546 "Eighteen cases were classified as AD and 13 as SCC by light microscopy and immunocytochemistry. miRNA expression profiles demonstrated considerable, statistically significant differences between AD and SCC, showing an upregulation of hsa-let-7a, hsa-let-7b, hsa-let-7c,hsa-let-7f, hsa-let-7g, hsa-let-7i, and hsa-miR-98 and a downregulation of hsa-miR-205 in AD specimens" -tissue_expression_up hsa-mir-98 "Carcinoma, Lung, Non-Small-Cell" 21622546 "Eighteen cases were classified as AD and 13 as SCC by light microscopy and immunocytochemistry. miRNA expression profiles demonstrated considerable, statistically significant differences between AD and SCC, showing an upregulation of hsa-let-7a, hsa-let-7b, hsa-let-7c,hsa-let-7f, hsa-let-7g, hsa-let-7i, and hsa-miR-98 and a downregulation of hsa-miR-205 in AD specimens" -tissue_expression_up hsa-mir-1271 Head And Neck Neoplasms 21637912 hsa-mir-1271 was upregulated compared with normal tissue. -tissue_expression_up hsa-mir-181a-2 Head And Neck Neoplasms 21637912 hsa-mir-181a-2* was upregulated compared with normal tissue. -tissue_expression_up hsa-mir-181b-1 Head And Neck Neoplasms 21637912 hsa-mir-181b was upregulated compared with normal tissue. -tissue_expression_up hsa-mir-181b-2 Head And Neck Neoplasms 21637912 hsa-mir-181b was upregulated compared with normal tissue. -tissue_expression_up hsa-mir-221 Head And Neck Neoplasms 21637912 hsa-mir-221* was upregulated compared with normal tissue. -tissue_expression_up hsa-mir-744 Head And Neck Neoplasms 21637912 hsa-mir-744 was upregulated compared with normal tissue. -tissue_expression_up hsa-mir-133b Lung Neoplasms 21648427 Mice treated with pre-miR-133b containing lipoplexes had mature miR-133b expression in lung ~52-fold higher than untreated mice. -tissue_expression_up hsa-mir-31 "Squamous Cell Carcinoma, Esophageal" 21658006 miR-31 was up-regulated in 77.8% of the ESCC tissues. Serum miR-31 levels in ESCC patients were significantly higher than in normal controls (P<0.001). -tissue_expression_up hsa-mir-106a "Carcinoma, Rectal" 21671476 "One of the most up-regulated miRNAs, miRNA-106a, was consistently reported to be differentially expressed in six studies and the five most down-regulated miRNAs, miR-30a-3p, miR-139, miR-145, miR-125a and miR-133a, were consistently reported to be differentially expressed in four studies." -tissue_expression_up hsa-mir-155 Rheumatoid Arthritis 21690378 "miR-155 is up-regulated in synovial membrane and synovial fluid (SF) macrophages from patients with rheumatoid arthritis (RA). The increased expression of miR-155 in SF CD14(+) cells was associated with lower expression of the miR-155 target, Src homology 2-containing inositol phosphatase-1 (SHIP-1), an inhibitor of inflammation." -tissue_expression_up hsa-let-7e Heart Failure 21690488 "The absolute expression levels of hcmv-miR-UL112, miR-296-5p, and let-7e were further determined in 127 patients and 67 control subjects (fold changes are 2.5, 0.5, and 1.7 respectively; all P<0.0001)." -tissue_expression_up hsa-mir-122 Hepatitis B Virus Infection 21692939 Expression of the liver-specific miR-122 was significantly up-regulated in HBV-infected patients. -tissue_expression_up hsa-mir-122 Liver Failure 21692939 The expression levels of miR-122 and miR-194 correlated negatively with the age of patients with CHB (chronic hepatitis B) or ACLF (acute-on-chronic liver failure). -tissue_expression_up hsa-mir-194-1 Liver Failure 21692939 The expression levels of miR-122 and miR-194 correlated negatively with the age of patients with CHB (chronic hepatitis B) or ACLF (acute-on-chronic liver failure). -tissue_expression_up hsa-mir-194-2 Liver Failure 21692939 The expression levels of miR-122 and miR-194 correlated negatively with the age of patients with CHB (chronic hepatitis B) or ACLF (acute-on-chronic liver failure). -tissue_expression_up hsa-mir-148a Gastric Neoplasms 21703006 "miR-148a could reduce the invasiveness, migratory and adhesive activities of gastric tumor cells. Most importantly, elevated miR-148a level in gastric cancer tissues was strongly correlated with distant metastasis, organ and peritoneal invasion and reduced survival rate." -tissue_expression_up hsa-mir-31 Kaposi Sarcoma 21715310 "In the present study, we show that Kaposi sarcoma-associated herpesvirus (KSHV), the etiological agent of KS, induces global miRNA changes in lymphatic endothelial cells (LECs). Specifically, the miR-221/miR-222 cluster is down-regulated, whereas miR-31 is up-regulated." -tissue_expression_up hsa-mir-17 Gastrointestinal Neoplasms 21743960 Our study suggests that the presence of BM-DTCs and the upregulation of the miR-17-92 cluster in tumors are both significant but independent prognostic markers in gastrointestinal cancer patients. -tissue_expression_up hsa-mir-18 Gastrointestinal Neoplasms 21743960 Our study suggests that the presence of BM-DTCs and the upregulation of the miR-17-92 cluster in tumors are both significant but independent prognostic markers in gastrointestinal cancer patients. -tissue_expression_up hsa-mir-19a Gastrointestinal Neoplasms 21743960 Our study suggests that the presence of BM-DTCs and the upregulation of the miR-17-92 cluster in tumors are both significant but independent prognostic markers in gastrointestinal cancer patients. -tissue_expression_up hsa-mir-19b-1 Gastrointestinal Neoplasms 21743960 Our study suggests that the presence of BM-DTCs and the upregulation of the miR-17-92 cluster in tumors are both significant but independent prognostic markers in gastrointestinal cancer patients. -tissue_expression_up hsa-mir-20a Gastrointestinal Neoplasms 21743960 Our study suggests that the presence of BM-DTCs and the upregulation of the miR-17-92 cluster in tumors are both significant but independent prognostic markers in gastrointestinal cancer patients. -tissue_expression_up hsa-mir-92-1 Gastrointestinal Neoplasms 21743960 Our study suggests that the presence of BM-DTCs and the upregulation of the miR-17-92 cluster in tumors are both significant but independent prognostic markers in gastrointestinal cancer patients. -tissue_expression_up hsa-mir-215 Colorectal Carcinoma 21752725 miR-215 has a unique potential as a prognostic biomarker in stage II and III colon cancer. -tissue_expression_up hsa-mir-21 "Adenocarcinoma, Pancreatic Ductal" 21757972 Elevated microRNA miR-21 Levels in Pancreatic Cyst Fluid Are Predictive of Mucinous Precursor Lesions of Ductal Adenocarcinoma. -tissue_expression_up hsa-mir-155 "Carcinoma, Hepatocellular" 21762537 ectopic expression of miR-155 upregulated the expression of several IFN-inducible antivirus genes in human hepatoma cells. -tissue_expression_up hsa-mir-106a Melanoma 21763111 "Early steps in skin tumor formation in HPV8-CER mice were associated with an upregulation of the oncogenic miRNA-17-5p, -21 and -106a and a downregulation of the tumor-suppressive miRNA-155 and -206, which could be demonstrated by qPCR and in situ hybridization." -tissue_expression_up hsa-mir-17 Melanoma 21763111 "Early steps in skin tumor formation in HPV8-CER mice were associated with an upregulation of the oncogenic miRNA-17-5p, -21 and -106a and a downregulation of the tumor-suppressive miRNA-155 and -206, which could be demonstrated by qPCR and in situ hybridization." -tissue_expression_up hsa-mir-21 Melanoma 21763111 "Early steps in skin tumor formation in HPV8-CER mice were associated with an upregulation of the oncogenic miRNA-17-5p, -21 and -106a and a downregulation of the tumor-suppressive miRNA-155 and -206, which could be demonstrated by qPCR and in situ hybridization." -tissue_expression_up hsa-mir-21 Renal Fibrosis 21775484 miR-21 expression was upregulated in response to treatment with TGF-beta1 or TNF-alpha in human renal tubular epithelial cells in vitro. -tissue_expression_up hsa-mir-181b "Carcinoma, Breast" 21779448 "we focused on miR-181b, which was overexpressed in several malignant neoplasias including breast carcinomas. " -tissue_expression_up hsa-mir-122 Thyroid Neoplasms 21779480 The miRNA increased 8.9-fold (P < 0.05) in all Thyroid Neoplasms versus normal. -tissue_expression_up hsa-mir-122 "Carcinoma, Renal Cell" 21784468 Overexpression -tissue_expression_up hsa-mir-155 "Carcinoma, Renal Cell" 21784468 Overexpression -tissue_expression_up hsa-mir-210 "Carcinoma, Renal Cell" 21784468 Overexpression -tissue_expression_up hsa-mir-145 "Lymphoma, B-Cell" 21803762 miR-9 is upregulated. -tissue_expression_up hsa-mir-17 "Lymphoma, B-Cell" 21803762 miR-17-5p is upregulated. -tissue_expression_up hsa-mir-193b "Lymphoma, B-Cell" 21803762 miR-9 is upregulated. -tissue_expression_up hsa-mir-199a-1 "Lymphoma, B-Cell" 21803762 miR-9 is upregulated. -tissue_expression_up hsa-mir-199a-2 "Lymphoma, B-Cell" 21803762 miR-9 is upregulated. -tissue_expression_up hsa-mir-20a "Lymphoma, B-Cell" 21803762 miR-20a is upregulated. -tissue_expression_up hsa-mir-214 "Lymphoma, B-Cell" 21803762 miR-9 is upregulated. -tissue_expression_up hsa-mir-9-1 "Lymphoma, B-Cell" 21803762 miR-9 is upregulated. -tissue_expression_up hsa-mir-9-2 "Lymphoma, B-Cell" 21803762 miR-9 is upregulated. -tissue_expression_up hsa-mir-9-3 "Lymphoma, B-Cell" 21803762 miR-9 is upregulated. -tissue_expression_up hsa-mir-146a Rheumatoid Arthritis 21810022 "miRNA 146a expression was significantly higher in patients with RA than in those with OA and in controls.In patients with RA, miRNA 146a positively correlated with TNF-a (p=0.0003), erythrocyte sedimentation rate (ESR)(p=0.022), and DAS 28 (p=0.009)." -tissue_expression_up hsa-mir-32 "Leukemia, Myeloid" 21816906 "MicroRNA-32 upregulation by 1,25-dihydroxyvitamin D3 in human myeloid leukemia cells leads to Bim targeting and inhibition of AraC-induced apoptosis." -tissue_expression_up hsa-let-7a-1 Colorectal Carcinoma 21826996 upregulated in colon cancer compared to normal colonic mucosa -tissue_expression_up hsa-let-7a-2 Colorectal Carcinoma 21826996 upregulated in colon cancer compared to normal colonic mucosa -tissue_expression_up hsa-let-7a-3 Colorectal Carcinoma 21826996 upregulated in colon cancer compared to normal colonic mucosa -tissue_expression_up hsa-mir-106a Colorectal Carcinoma 21826996 upregulated in colon cancer compared to normal colonic mucosa -tissue_expression_up hsa-mir-17 Colorectal Carcinoma 21826996 upregulated in colon cancer compared to normal colonic mucosa -tissue_expression_up hsa-mir-182 Colorectal Carcinoma 21826996 upregulated in colon cancer compared to normal colonic mucosa -tissue_expression_up hsa-mir-200c Colorectal Carcinoma 21826996 upregulated in colon cancer compared to normal colonic mucosa -tissue_expression_up hsa-mir-20a Colorectal Carcinoma 21826996 upregulated in colon cancer compared to normal colonic mucosa -tissue_expression_up hsa-mir-92a-1 Colorectal Carcinoma 21826996 upregulated in colon cancer compared to normal colonic mucosa -tissue_expression_up hsa-mir-92a-2 Colorectal Carcinoma 21826996 upregulated in colon cancer compared to normal colonic mucosa -tissue_expression_up hsa-mir-93 Colorectal Carcinoma 21826996 upregulated in colon cancer compared to normal colonic mucosa -tissue_expression_up hsa-mir-491 Glioblastoma 21831363 "miR-491-5p has high positive correlation with MMP-9 expression and its upregulation was demonstrated to reduce the levels of MMP-9 expression and inhibit cellular invasion in U251 and U87 glioma cells. Furthermore, miR-491-5p suppressed glioma cell invasion via targeting MMP-9 directly." -tissue_expression_up hsa-mir-885 Glioblastoma 21831363 miR-885-5p has high positive correlation with MMP-9 expression and its upregulation was demonstrated to reduce the levels of MMP-9 expression and inhibit cellular invasion in U251 and U87 glioma cells. -tissue_expression_up hsa-mir-148a Alzheimer Disease 21834602 upregulated in bone marrow plasma cells from patients with immunoglobulin light chain (AL) amyloidosis compared with controls. -tissue_expression_up hsa-mir-16-2 Alzheimer Disease 21834602 upregulated in bone marrow plasma cells from patients with immunoglobulin light chain (AL) amyloidosis compared with controls. -tissue_expression_up hsa-mir-26a-1 Alzheimer Disease 21834602 upregulated in bone marrow plasma cells from patients with immunoglobulin light chain (AL) amyloidosis compared with controls. -tissue_expression_up hsa-mir-26a-2 Alzheimer Disease 21834602 upregulated in bone marrow plasma cells from patients with immunoglobulin light chain (AL) amyloidosis compared with controls. -tissue_expression_up hsa-mir-100 Muscular Dystrophy 21840938 highly expressed in fetal muscle. -tissue_expression_up hsa-mir-127 Muscular Dystrophy 21840938 miR-127-3p: highly expressed in fetal muscle. -tissue_expression_up hsa-mir-136 Muscular Dystrophy 21840938 miR-136*: highly expressed in fetal muscle. -tissue_expression_up hsa-mir-148a Muscular Dystrophy 21840938 highly expressed in fetal muscle. -tissue_expression_up hsa-mir-192 Muscular Dystrophy 21840938 highly expressed in fetal muscle. -tissue_expression_up hsa-mir-335 Muscular Dystrophy 21840938 highly expressed in fetal muscle. -tissue_expression_up hsa-mir-376c Muscular Dystrophy 21840938 highly expressed in fetal muscle. -tissue_expression_up hsa-mir-489 Muscular Dystrophy 21840938 highly expressed in fetal muscle. -tissue_expression_up hsa-mir-502 Muscular Dystrophy 21840938 miR-502-3p: highly expressed in fetal muscle. -tissue_expression_up hsa-let-7f-2 Biliary Tract Neoplasms 21858175 The miRNA let-7f-2* was significantly more highly expressed in the malignant group than in the benign group. -tissue_expression_up hsa-let-7i Biliary Tract Neoplasms 21858175 The miRNA let-7i* was significantly more highly expressed in the malignant group than in the benign group. -tissue_expression_up hsa-mir-105-1 Biliary Tract Neoplasms 21858175 The miRNA was significantly more highly expressed in the malignant group than in the benign group. -tissue_expression_up hsa-mir-105-2 Biliary Tract Neoplasms 21858175 The miRNA was significantly more highly expressed in the malignant group than in the benign group. -tissue_expression_up hsa-mir-145 Biliary Tract Neoplasms 21858175 The miRNA miR-145* was significantly more highly expressed in the malignant group than in the benign group. -tissue_expression_up hsa-mir-147b Biliary Tract Neoplasms 21858175 The miRNA was significantly more highly expressed in the malignant group than in the benign group. -tissue_expression_up hsa-mir-199a-1 Biliary Tract Neoplasms 21858175 The miRNA miR-199a-3p was significantly more highly expressed in the malignant group than in the benign group. -tissue_expression_up hsa-mir-199a-2 Biliary Tract Neoplasms 21858175 The miRNA miR-199a-3p was significantly more highly expressed in the malignant group than in the benign group. -tissue_expression_up hsa-mir-222 Biliary Tract Neoplasms 21858175 The miRNA miR-222* was significantly more highly expressed in the malignant group than in the benign group. -tissue_expression_up hsa-mir-302c Biliary Tract Neoplasms 21858175 The miRNA miR-302c* was significantly more highly expressed in the malignant group than in the benign group. -tissue_expression_up hsa-mir-9-1 Biliary Tract Neoplasms 21858175 The miRNA was significantly more highly expressed in the malignant group than in the benign group. -tissue_expression_up hsa-mir-9-2 Biliary Tract Neoplasms 21858175 The miRNA was significantly more highly expressed in the malignant group than in the benign group. -tissue_expression_up hsa-mir-9-3 Biliary Tract Neoplasms 21858175 The miRNA was significantly more highly expressed in the malignant group than in the benign group. -tissue_expression_up hsa-mir-942 Biliary Tract Neoplasms 21858175 The miRNA was significantly more highly expressed in the malignant group than in the benign group. -tissue_expression_up hsa-mir-21 "Carcinoma, Adrenocortical" 21859927 "Among others, miR-483-3p, miR-483-5p, miR-210, and miR-21 were found overexpressed,while miR-195, miR-497, and miR-1974 were underexpressed in ACC. " -tissue_expression_up hsa-mir-210 "Carcinoma, Adrenocortical" 21859927 "Among others, miR-483-3p, miR-483-5p, miR-210, and miR-21 were found overexpressed,while miR-195, miR-497, and miR-1974 were underexpressed in ACC. " -tissue_expression_up hsa-mir-483 "Carcinoma, Adrenocortical" 21859927 "Among others, miR-483-3p, miR-483-5p, miR-210, and miR-21 were found overexpressed,while miR-195, miR-497, and miR-1974 were underexpressed in ACC. " -tissue_expression_up hsa-mir-506 Melanoma 21860416 "miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf." -tissue_expression_up hsa-mir-507 Melanoma 21860416 "miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf." -tissue_expression_up hsa-mir-508 Melanoma 21860416 "miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf." -tissue_expression_up hsa-mir-509-1 Melanoma 21860416 "miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf." -tissue_expression_up hsa-mir-509-2 Melanoma 21860416 "miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf." -tissue_expression_up hsa-mir-509-3 Melanoma 21860416 "miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf." -tissue_expression_up hsa-mir-510 Melanoma 21860416 "miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf." -tissue_expression_up hsa-mir-513a-1 Melanoma 21860416 "miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf." -tissue_expression_up hsa-mir-513a-2 Melanoma 21860416 "miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf." -tissue_expression_up hsa-mir-513b Melanoma 21860416 "miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf." -tissue_expression_up hsa-mir-513c Melanoma 21860416 "miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf." -tissue_expression_up hsa-mir-514a-1 Melanoma 21860416 "miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf." -tissue_expression_up hsa-mir-514a-2 Melanoma 21860416 "miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf." -tissue_expression_up hsa-mir-514a-3 Melanoma 21860416 "miR-506-514 cluster was consistently overexpressed in nearly all melanomas tested (30-60 fold, P<0.001), regardless of mutations in N-ras or B-raf." -tissue_expression_up hsa-mir-155 Melanoma 21863027 PCR analysis revealed primary cutaneous melanomas had an 8.6-fold overexpression of miR-21 and a 7.5-fold overexpression of miR-155 compared with benign naevi (P<0.0001). -tissue_expression_up hsa-mir-21 Melanoma 21863027 PCR analysis revealed primary cutaneous melanomas had an 8.6-fold overexpression of miR-21 and a 7.5-fold overexpression of miR-155 compared with benign naevi (P<0.0001). -tissue_expression_up hsa-mir-144 Colorectal Carcinoma 21863218 Differential expression of miR-144* as a novel fecal-based diagnostic marker for colorectal cancer. -tissue_expression_up hsa-mir-181b-1 Gastric Neoplasms 21876743 Doxifluridine/Oxaliplatin treated advanced stage gastric cancer patients. The expression of miR-181b and miR-21 was significantly overexpressed in gastric tumors compared to normal gastric tissues. -tissue_expression_up hsa-mir-181b-2 Gastric Neoplasms 21876743 Doxifluridine/Oxaliplatin treated advanced stage gastric cancer patients. The expression of miR-181b and miR-21 was significantly overexpressed in gastric tumors compared to normal gastric tissues. -tissue_expression_up hsa-mir-21 Gastric Neoplasms 21876743 Doxifluridine/Oxaliplatin treated advanced stage gastric cancer patients. The expression of miR-181b and miR-21 was significantly overexpressed in gastric tumors compared to normal gastric tissues. -tissue_expression_up hsa-mir-142 "Squamous Cell Carcinoma, Esophageal" 21882196 "MiR-31 and miR-142-3p expression were correlated to histological differentiation in ESCC (P<0.05, Student's t-test); high miR-142-3p expression was associated with a poor prognosis in all 91 ESCC patients (P=0.014, log-rank) and identified as an independent prognostic factor in ESCC (P=0.017, univariate Cox; P=0.022, multivariate Cox). More importantly, stratified analysis indicated that high miR-142-3p expression was correlated to a poor prognosis within good-prognosis groups comprised of ESCC patients with small tumor size, negative lymph node metastasis, or early stage (all P<0.05)." -tissue_expression_up hsa-mir-31 "Squamous Cell Carcinoma, Esophageal" 21882196 "MiR-31 and miR-142-3p expression were correlated to histological differentiation in ESCC (P<0.05, Student's t-test); high miR-142-3p expression was associated with a poor prognosis in all 91 ESCC patients (P=0.014, log-rank) and identified as an independent prognostic factor in ESCC (P=0.017, univariate Cox; P=0.022, multivariate Cox). More importantly, stratified analysis indicated that high miR-142-3p expression was correlated to a poor prognosis within good-prognosis groups comprised of ESCC patients with small tumor size, negative lymph node metastasis, or early stage (all P<0.05)." -tissue_expression_up hsa-mir-21 "Squamous Cell Carcinoma, Esophageal" 21883657 miR-21 expression was significantly up-regulated in the whole spectrum of preneoplastic/neoplastic lesions considered. -tissue_expression_up hsa-mir-133a-1 "Cardiomyopathy, Hypertrophic" 21893044 Hydrogen sulphide inhibits cardiomyocyte hypertrophy by up-regulating miR-133a. -tissue_expression_up hsa-mir-133a-1 Hypertrophy 21893044 Hydrogen sulphide inhibits cardiomyocyte hypertrophy by up-regulating miR-133a -tissue_expression_up hsa-mir-133a-2 "Cardiomyopathy, Hypertrophic" 21893044 Hydrogen sulphide inhibits cardiomyocyte hypertrophy by up-regulating miR-133a. -tissue_expression_up hsa-mir-133a-2 Hypertrophy 21893044 Hydrogen sulphide inhibits cardiomyocyte hypertrophy by up-regulating miR-133a -tissue_expression_up hsa-mir-141 Endometrial Neoplasms 21897839 "The entire miR-200 family (miR-200a/b/c, miR-141, and miR-429) was up-regulated in cases of EEC (endometrioid endometrial adenocarcinoma)." -tissue_expression_up hsa-mir-200a Endometrial Neoplasms 21897839 "The entire miR-200 family (miR-200a/b/c, miR-141, and miR-429) was up-regulated in cases of EEC (endometrioid endometrial adenocarcinoma)." -tissue_expression_up hsa-mir-200b Endometrial Neoplasms 21897839 "The entire miR-200 family (miR-200a/b/c, miR-141, and miR-429) was up-regulated in cases of EEC (endometrioid endometrial adenocarcinoma)." -tissue_expression_up hsa-mir-200c Endometrial Neoplasms 21897839 "The entire miR-200 family (miR-200a/b/c, miR-141, and miR-429) was up-regulated in cases of EEC (endometrioid endometrial adenocarcinoma)." -tissue_expression_up hsa-mir-429 Endometrial Neoplasms 21897839 "The entire miR-200 family (miR-200a/b/c, miR-141, and miR-429) was up-regulated in cases of EEC (endometrioid endometrial adenocarcinoma)." -tissue_expression_up hsa-mir-141 "Carcinoma, Ehrlich Tumor" 21899346 "Two clusters miR-183~miR-96~miR-182 and miR-200b~miR-200a~miR-429 as well as miR-141 to be consistently up-regulated in the MDR (Multidrug resistance) cell lines, while miR-125b-5p and the two clusters miR-30d~miR-30b and miR-23b~miR-27b~miR-24-1 were down-regulated in most of the resistant EAT (Ehrlich ascites tumor) cells." -tissue_expression_up hsa-mir-182 "Carcinoma, Ehrlich Tumor" 21899346 "Two clusters miR-183~miR-96~miR-182 and miR-200b~miR-200a~miR-429 as well as miR-141 to be consistently up-regulated in the MDR (Multidrug resistance) cell lines, while miR-125b-5p and the two clusters miR-30d~miR-30b and miR-23b~miR-27b~miR-24-1 were down-regulated in most of the resistant EAT (Ehrlich ascites tumor) cells." -tissue_expression_up hsa-mir-183 "Carcinoma, Ehrlich Tumor" 21899346 "Two clusters miR-183~miR-96~miR-182 and miR-200b~miR-200a~miR-429 as well as miR-141 to be consistently up-regulated in the MDR (Multidrug resistance) cell lines, while miR-125b-5p and the two clusters miR-30d~miR-30b and miR-23b~miR-27b~miR-24-1 were down-regulated in most of the resistant EAT (Ehrlich ascites tumor) cells." -tissue_expression_up hsa-mir-200a "Carcinoma, Ehrlich Tumor" 21899346 "Two clusters miR-183~miR-96~miR-182 and miR-200b~miR-200a~miR-429 as well as miR-141 to be consistently up-regulated in the MDR (Multidrug resistance) cell lines, while miR-125b-5p and the two clusters miR-30d~miR-30b and miR-23b~miR-27b~miR-24-1 were down-regulated in most of the resistant EAT (Ehrlich ascites tumor) cells." -tissue_expression_up hsa-mir-200b "Carcinoma, Ehrlich Tumor" 21899346 "Two clusters miR-183~miR-96~miR-182 and miR-200b~miR-200a~miR-429 as well as miR-141 to be consistently up-regulated in the MDR (Multidrug resistance) cell lines, while miR-125b-5p and the two clusters miR-30d~miR-30b and miR-23b~miR-27b~miR-24-1 were down-regulated in most of the resistant EAT (Ehrlich ascites tumor) cells." -tissue_expression_up hsa-mir-429 "Carcinoma, Ehrlich Tumor" 21899346 "Two clusters miR-183~miR-96~miR-182 and miR-200b~miR-200a~miR-429 as well as miR-141 to be consistently up-regulated in the MDR (Multidrug resistance) cell lines, while miR-125b-5p and the two clusters miR-30d~miR-30b and miR-23b~miR-27b~miR-24-1 were down-regulated in most of the resistant EAT (Ehrlich ascites tumor) cells." -tissue_expression_up hsa-mir-96 "Carcinoma, Ehrlich Tumor" 21899346 "Two clusters miR-183~miR-96~miR-182 and miR-200b~miR-200a~miR-429 as well as miR-141 to be consistently up-regulated in the MDR (Multidrug resistance) cell lines, while miR-125b-5p and the two clusters miR-30d~miR-30b and miR-23b~miR-27b~miR-24-1 were down-regulated in most of the resistant EAT (Ehrlich ascites tumor) cells." -tissue_expression_up hsa-mir-27b Glioblastoma 21922148 "Real-time PCR showed that miR-27b was up-regulated in glioma samples and glioma cells. Down-regulation of miR-27b triggered growth inhibition, induced apoptosis and inhibited invasion in glioma cells. In addition, Western blot assay showed that STAT3, c-myc and cyclin D1 were knocked down after treatment with miR-27b inhibitor." -tissue_expression_up hsa-mir-27b Glioma 21922148 Real-time PCR showed that miR-27b was up-regulated in glioma samples and glioma cells. -tissue_expression_up hsa-mir-21 Colorectal Carcinoma 21930727 "The expression of miR-21 and miR-92a was significantly higher in CRC tissues compared with their adjacent normal tissues (p<0.0001). Patients with CRC had a significantly higher stool miR-21 level (p<0.01) and miR-92a level (p<0.0001) compared with normal controls. Stool miR-92a, but not miR-21, was significantly higher in patients with polyps than in controls (p<0.0001). At a cut-off value of 435 copies/ng of stool RNA, miR-92a had a sensitivity of 71.6% and 56.1% for CRC and polyp, respectively, and a specificity of 73.3%. In addition, the stool miR-92a level demonstrated a higher sensitivity for distal CRC than proximal CRC (p<0.05), and a higher sensitivity for advanced adenoma than minor polyps (p<0.05). Removal of tumour resulted in reduced stool miR-21 and miR-92a levels (p<0.01), and the removal of advanced adenoma resulted in a reduction of the stool miR-92a level (p<0.05)." -tissue_expression_up hsa-mir-92a-1 Colorectal Carcinoma 21930727 "The expression of miR-21 and miR-92a was significantly higher in CRC tissues compared with their adjacent normal tissues (p<0.0001). Patients with CRC had a significantly higher stool miR-21 level (p<0.01) and miR-92a level (p<0.0001) compared with normal controls. Stool miR-92a, but not miR-21, was significantly higher in patients with polyps than in controls (p<0.0001). At a cut-off value of 435 copies/ng of stool RNA, miR-92a had a sensitivity of 71.6% and 56.1% for CRC and polyp, respectively, and a specificity of 73.3%. In addition, the stool miR-92a level demonstrated a higher sensitivity for distal CRC than proximal CRC (p<0.05), and a higher sensitivity for advanced adenoma than minor polyps (p<0.05). Removal of tumour resulted in reduced stool miR-21 and miR-92a levels (p<0.01), and the removal of advanced adenoma resulted in a reduction of the stool miR-92a level (p<0.05)." -tissue_expression_up hsa-mir-92a-2 Colorectal Carcinoma 21930727 "The expression of miR-21 and miR-92a was significantly higher in CRC tissues compared with their adjacent normal tissues (p<0.0001). Patients with CRC had a significantly higher stool miR-21 level (p<0.01) and miR-92a level (p<0.0001) compared with normal controls. Stool miR-92a, but not miR-21, was significantly higher in patients with polyps than in controls (p<0.0001). At a cut-off value of 435 copies/ng of stool RNA, miR-92a had a sensitivity of 71.6% and 56.1% for CRC and polyp, respectively, and a specificity of 73.3%. In addition, the stool miR-92a level demonstrated a higher sensitivity for distal CRC than proximal CRC (p<0.05), and a higher sensitivity for advanced adenoma than minor polyps (p<0.05). Removal of tumour resulted in reduced stool miR-21 and miR-92a levels (p<0.01), and the removal of advanced adenoma resulted in a reduction of the stool miR-92a level (p<0.05)." -tissue_expression_up hsa-mir-126 Medulloblastoma 21931624 hsa-mir-126 was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_up hsa-mir-127 Medulloblastoma 21931624 hsa-mir-127-3p was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_up hsa-mir-143 Medulloblastoma 21931624 hsa-mir-143 was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_up hsa-mir-144 Medulloblastoma 21931624 hsa-mir-144* was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_up hsa-mir-145 Medulloblastoma 21931624 hsa-mir-145 was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_up hsa-mir-146a Medulloblastoma 21931624 hsa-mir-146a was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_up hsa-mir-193a Medulloblastoma 21931624 hsa-mir-193a-5p was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_up hsa-mir-203 Medulloblastoma 21931624 hsa-mir-203 was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_up hsa-mir-21 Medulloblastoma 21931624 hsa-mir-21* was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_up hsa-mir-223 Medulloblastoma 21931624 hsa-mir-223 was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_up hsa-mir-323a Medulloblastoma 21931624 hsa-mir-323-3p was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_up hsa-mir-338 Medulloblastoma 21931624 hsa-mir-338-3p was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_up hsa-mir-361 Medulloblastoma 21931624 hsa-mir-361-3p was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_up hsa-mir-376a-1 Medulloblastoma 21931624 hsa-mir-376 was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_up hsa-mir-376a-2 Medulloblastoma 21931624 hsa-mir-376 was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_up hsa-mir-376c Medulloblastoma 21931624 hsa-mir-376c was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_up hsa-mir-379 Medulloblastoma 21931624 hsa-mir-379 was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_up hsa-mir-409 Medulloblastoma 21931624 hsa-mir-409-3p was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_up hsa-mir-494 Medulloblastoma 21931624 hsa-mir-494 was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_up hsa-mir-495 Medulloblastoma 21931624 hsa-mir-495 was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_up hsa-mir-539 Medulloblastoma 21931624 hsa-mir-539 was significantly up-regulated in primary Medulloblastoma specimens relative to CD133+ NSCs (Neural Stem Cells). -tissue_expression_up hsa-mir-1-1 Breast Neoplasms 21931769 "ATF-126 and Maspin cDNA induction led to the re-activation of tumor suppressive miRNAs also expressed in neural cells, such as miR-1 and miR-34, and to the down-regulation of potential oncogenic miRNAs, such as miR-10b, miR-124, and miR-363." -tissue_expression_up hsa-mir-1-2 Breast Neoplasms 21931769 "ATF-126 and Maspin cDNA induction led to the re-activation of tumor suppressive miRNAs also expressed in neural cells, such as miR-1 and miR-34, and to the down-regulation of potential oncogenic miRNAs, such as miR-10b, miR-124, and miR-363." -tissue_expression_up hsa-mir-34a Breast Neoplasms 21931769 "ATF-126 and Maspin cDNA induction led to the re-activation of tumor suppressive miRNAs also expressed in neural cells, such as miR-1 and miR-34, and to the down-regulation of potential oncogenic miRNAs, such as miR-10b, miR-124, and miR-363." -tissue_expression_up hsa-mir-223 Breast Neoplasms 21939504 "miR-223, a miRNA specific for IL-4-activated macrophages, was detected within the exosomes released by macrophages and was significantly elevated in the co-cultivated SKBR3 and MDA-MB-231 cells." -tissue_expression_up hsa-mir-1299 Ovarian Neoplasms 21939554 The miRNA was upregulated in cis-platin resistant (A2780/CP70) vs. cis-platin sensitive (A2780) ovarian cancer cell lines. -tissue_expression_up hsa-mir-193b Ovarian Neoplasms 21939554 The miRNA was upregulated in cis-platin resistant (A2780/CP70) vs. cis-platin sensitive (A2780) ovarian cancer cell lines. -tissue_expression_up hsa-mir-300 Ovarian Neoplasms 21939554 The miRNA was upregulated in cis-platin resistant (A2780/CP70) vs. cis-platin sensitive (A2780) ovarian cancer cell lines. -tissue_expression_up hsa-mir-642a Ovarian Neoplasms 21939554 The miRNA was upregulated in cis-platin resistant (A2780/CP70) vs. cis-platin sensitive (A2780) ovarian cancer cell lines. -tissue_expression_up hsa-let-7c Retinoblastoma 21941147 differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth. -tissue_expression_up hsa-let-7i Retinoblastoma 21941147 differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth. -tissue_expression_up hsa-mir-10b Retinoblastoma 21941147 differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth. -tissue_expression_up hsa-mir-124-1 Retinoblastoma 21941147 differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth. -tissue_expression_up hsa-mir-124-2 Retinoblastoma 21941147 differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth. -tissue_expression_up hsa-mir-124-3 Retinoblastoma 21941147 differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth. -tissue_expression_up hsa-mir-135b Retinoblastoma 21941147 differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth. -tissue_expression_up hsa-mir-142 Retinoblastoma 21941147 hsa-mir-142-5p: differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth. -tissue_expression_up hsa-mir-29a Retinoblastoma 21941147 differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth. -tissue_expression_up hsa-mir-29b-1 Retinoblastoma 21941147 differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth. -tissue_expression_up hsa-mir-29b-2 Retinoblastoma 21941147 differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth. -tissue_expression_up hsa-mir-29c Retinoblastoma 21941147 differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth. -tissue_expression_up hsa-mir-34a Retinoblastoma 21941147 differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth. -tissue_expression_up hsa-mir-34c Retinoblastoma 21941147 hsa-mir-34c-5p: differential expression between RB cell lines of different growth patterns: SNUOT-Rb1 with adherent and more rapid growth and Y79 with nonadherent and slower growth. -tissue_expression_up hsa-mir-203 Lichen Planus 21943223 "Increased expression of miR-21 and miR-203, decreased expression of miR-125, and down-regulation of p53 and deltaNp63 RNA were seen in OLP compared to normal oral mucosa. When comparing microRNA expression to levels of p53 and p63 RNA, a significant negative correlation was seen between deltaNp63 and miR-203 and between miR-21 and p53, respectively." -tissue_expression_up hsa-mir-21 Lichen Planus 21943223 "Increased expression of miR-21 and miR-203, decreased expression of miR-125, and down-regulation of p53 and deltaNp63 RNA were seen in OLP compared to normal oral mucosa. When comparing microRNA expression to levels of p53 and p63 RNA, a significant negative correlation was seen between deltaNp63 and miR-203 and between miR-21 and p53, respectively." -tissue_expression_up hsa-mir-34c Alzheimer Disease 21946562 The authors identify miR-34c as a negative constraint of memory consolidation and show that miR-34c levels are elevated in the hippocampus of AD patients and corresponding mouse models. -tissue_expression_up hsa-mir-182 Breast Neoplasms 21953071 The miRNA was up-regulated during lobular neoplasia progression compared to normal epithelium. -tissue_expression_up hsa-mir-183 Breast Neoplasms 21953071 The miRNA was up-regulated during lobular neoplasia progression compared to normal epithelium. -tissue_expression_up hsa-mir-203 Breast Neoplasms 21953071 The miRNA was up-regulated during lobular neoplasia progression compared to normal epithelium. -tissue_expression_up hsa-mir-375 Breast Neoplasms 21953071 The miRNA was up-regulated during lobular neoplasia progression compared to normal epithelium. Hsa-miR-375 is differentially expressed during breast lobular neoplasia and promotes loss of mammary acinar polarity. -tissue_expression_up hsa-mir-425 Breast Neoplasms 21953071 miR-425-5p was up-regulated during lobular neoplasia progression compared to normal epithelium. -tissue_expression_up hsa-mir-194-1 Pancreatic Neoplasms 21953293 Highly up-regulated in PDAC compared with normal ductal -tissue_expression_up hsa-mir-194-2 Pancreatic Neoplasms 21953293 Highly up-regulated in PDAC compared with normal ductal -tissue_expression_up hsa-mir-210 Pancreatic Neoplasms 21953293 Highly up-regulated in PDAC compared with normal ductal -tissue_expression_up hsa-mir-425 Pancreatic Neoplasms 21953293 Highly up-regulated in PDAC compared with normal ductal -tissue_expression_up hsa-mir-429 Pancreatic Neoplasms 21953293 Highly up-regulated in PDAC compared with normal ductal -tissue_expression_up hsa-mir-210 Lung Neoplasms 21965273 Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR-210 expression caused by stabilizing HIF-1{alpha} -tissue_expression_up hsa-mir-155 Mycosis Fungoides 21966986 "MiR-155 was only found to be slightly overexpressed in MF compared to healthy controls. Furthermore, metastatic MF demonstrated lower concentrations of let-7a, let-7d and let-7f when compared to MF limited to the skin." -tissue_expression_up hsa-mir-106a Alopecia 21967250 "We detected the significant upregulation of miR-221, miR-125b, miR-106a and miR-410 in balding papilla cells." -tissue_expression_up hsa-mir-125b Alopecia 21967250 "We detected the significant upregulation of miR-221, miR-125b, miR-106a and miR-410 in balding papilla cells." -tissue_expression_up hsa-mir-221 Alopecia 21967250 "We detected the significant upregulation of miR-221, miR-125b, miR-106a and miR-410 in balding papilla cells." -tissue_expression_up hsa-mir-410 Alopecia 21967250 "We detected the significant upregulation of miR-221, miR-125b, miR-106a and miR-410 in balding papilla cells." -tissue_expression_up hsa-mir-21 Pancreatic Neoplasms 21983937 "miRNA-21 was the most significantly overexpressed miRNA in the pancreatic ductal adenocarcinomas analyzed, and was also highly expressed in 75% of the 65 pancreatic ductal adenocarcinomas examined by real-time RT-PCR. High miRNA-21 expression was correlated with a worse prognosis in the pancreatic ductal adenocarcinoma patients (P=0.045). The immunohistochemical expression patterns of PDCD4 (reduced nuclear staining pattern) and TIMP3 (downregulated expression) were significantly associated with both the upregulated miR-21 expression (P<0.05) and the poor survival of the patients (P<0.001 and P=0.001, respectively). Our data suggest that an overexpression of miRNA-21 is, therefore, associated with the biological behavior of pancreatic ductal adenocarcinoma via the downregulation of the expression of tumor suppressors, PDCD4 and TIMP3, thus resulting in tumor progression and the adverse clinical course of pancreatic ductal adenocarcinoma." -tissue_expression_up hsa-mir-155 "Lymphoma, B-Cell" 21987025 "Four of miRNAs (miR-15a, miR-16-1, miR-29c, and miR-155) were significantly elevated in DLBCL (diffuse large B cell lymphoma) serum when compared with normal controls (P<0.05), while miR-34a was downregulated in DLBCL serum when compared with controls (P<0.05). Receiver operating characteristic analyses reflects strong discriminating DLBCL from controls, with area under the curves of 0.7722, 0.7002, 0.6672, 0.8538, and 0.7157 for miR-15a, miR-16-1, miR-29c, miR-34a, and miR-155, respectively. At the cut-off value of 0.0006 for miR-15a, the sensitivity was 80% and the specificity was 76%; at the cut-off value of 0.0886 for miR-16-1, the sensitivity was 94% and the specificity was 51%; at the cut-off value of 1.395 for miR-34a, the sensitivity was 100% and the specificity was 70%; at the cut-off value of 0.0022 for miR-155, the sensitivity was 83% and the specificity was 65%." -tissue_expression_up hsa-mir-15a "Lymphoma, B-Cell" 21987025 "Four of miRNAs (miR-15a, miR-16-1, miR-29c, and miR-155) were significantly elevated in DLBCL (diffuse large B cell lymphoma) serum when compared with normal controls (P<0.05), while miR-34a was downregulated in DLBCL serum when compared with controls (P<0.05). Receiver operating characteristic analyses reflects strong discriminating DLBCL from controls, with area under the curves of 0.7722, 0.7002, 0.6672, 0.8538, and 0.7157 for miR-15a, miR-16-1, miR-29c, miR-34a, and miR-155, respectively. At the cut-off value of 0.0006 for miR-15a, the sensitivity was 80% and the specificity was 76%; at the cut-off value of 0.0886 for miR-16-1, the sensitivity was 94% and the specificity was 51%; at the cut-off value of 1.395 for miR-34a, the sensitivity was 100% and the specificity was 70%; at the cut-off value of 0.0022 for miR-155, the sensitivity was 83% and the specificity was 65%." -tissue_expression_up hsa-mir-16-1 "Lymphoma, B-Cell" 21987025 "Four of miRNAs (miR-15a, miR-16-1, miR-29c, and miR-155) were significantly elevated in DLBCL (diffuse large B cell lymphoma) serum when compared with normal controls (P<0.05), while miR-34a was downregulated in DLBCL serum when compared with controls (P<0.05). Receiver operating characteristic analyses reflects strong discriminating DLBCL from controls, with area under the curves of 0.7722, 0.7002, 0.6672, 0.8538, and 0.7157 for miR-15a, miR-16-1, miR-29c, miR-34a, and miR-155, respectively. At the cut-off value of 0.0006 for miR-15a, the sensitivity was 80% and the specificity was 76%; at the cut-off value of 0.0886 for miR-16-1, the sensitivity was 94% and the specificity was 51%; at the cut-off value of 1.395 for miR-34a, the sensitivity was 100% and the specificity was 70%; at the cut-off value of 0.0022 for miR-155, the sensitivity was 83% and the specificity was 65%." -tissue_expression_up hsa-mir-29c "Lymphoma, B-Cell" 21987025 "Four of miRNAs (miR-15a, miR-16-1, miR-29c, and miR-155) were significantly elevated in DLBCL (diffuse large B cell lymphoma) serum when compared with normal controls (P<0.05), while miR-34a was downregulated in DLBCL serum when compared with controls (P<0.05). Receiver operating characteristic analyses reflects strong discriminating DLBCL from controls, with area under the curves of 0.7722, 0.7002, 0.6672, 0.8538, and 0.7157 for miR-15a, miR-16-1, miR-29c, miR-34a, and miR-155, respectively. At the cut-off value of 0.0006 for miR-15a, the sensitivity was 80% and the specificity was 76%; at the cut-off value of 0.0886 for miR-16-1, the sensitivity was 94% and the specificity was 51%; at the cut-off value of 1.395 for miR-34a, the sensitivity was 100% and the specificity was 70%; at the cut-off value of 0.0022 for miR-155, the sensitivity was 83% and the specificity was 65%." -tissue_expression_up hsa-mir-146a Systemic Lupus Erythematosus 21987229 "The levels of urinary miR-146a and miR-155 in patients with SLE were significantly higher than that in healthy controls. Calcitriol treatment reduced the levels of urinary miR-155 in patients with SLE. The level of urinary miR-146a significantly correlated with estimated glomerular filtration rate. The level of urinary miR-155 significantly correlated with proteinuria and systemic lupus erythematosus disease activity index (r=0.278, P=0.002). The level of urinary miR-146a reversely correlated with the urinary expression of TNF-a. Our results suggested that miR-146a and miR-155 might play important roles in the pathophysiology of SLE and the levels of urinary miR-146a and miR-155 could be used as potential markers for diagnosis, disease activity, and therapeutic response." -tissue_expression_up hsa-mir-155 Systemic Lupus Erythematosus 21987229 "The levels of urinary miR-146a and miR-155 in patients with SLE were significantly higher than that in healthy controls. Calcitriol treatment reduced the levels of urinary miR-155 in patients with SLE. The level of urinary miR-146a significantly correlated with estimated glomerular filtration rate. The level of urinary miR-155 significantly correlated with proteinuria and systemic lupus erythematosus disease activity index (r=0.278, P=0.002). The level of urinary miR-146a reversely correlated with the urinary expression of TNF-a. Our results suggested that miR-146a and miR-155 might play important roles in the pathophysiology of SLE and the levels of urinary miR-146a and miR-155 could be used as potential markers for diagnosis, disease activity, and therapeutic response." -tissue_expression_up hsa-mir-96 Urinary Bladder Cancer 21993544 hsa-mir-96 up-regulates MAP4K1 and IRS1 and may function as a promising diagnostic marker in human bladder urothelial carcinomas. -tissue_expression_up hsa-mir-1224 "Carcinoma, Hepatocellular" 21998738 hsa-mir-1224-3p was up-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract. -tissue_expression_up hsa-mir-1234 "Carcinoma, Hepatocellular" 21998738 hsa-mir-1234 was up-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract. -tissue_expression_up hsa-mir-1249 "Carcinoma, Hepatocellular" 21998738 hsa-mir-1249 was up-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract. -tissue_expression_up hsa-mir-15b "Carcinoma, Hepatocellular" 21998738 hsa-mir-15b* was up-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract. -tissue_expression_up hsa-mir-197 "Carcinoma, Hepatocellular" 21998738 hsa-mir-197 was up-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract. -tissue_expression_up hsa-mir-449b "Carcinoma, Hepatocellular" 21998738 hsa-mir-449b* was up-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract. -tissue_expression_up hsa-mir-522 "Carcinoma, Hepatocellular" 21998738 hsa-mir-522 was up-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract. -tissue_expression_up hsa-mir-532 "Carcinoma, Hepatocellular" 21998738 hsa-mir-532-3p was up-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract. -tissue_expression_up hsa-mir-744 "Carcinoma, Hepatocellular" 21998738 hsa-mir-744* was up-regulated in HepG2 cells after 5 hours of culture with grape seed proanthocyanidin extract. -tissue_expression_up hsa-mir-146a Osteoarthritis 22006119 "The relative expression levels of miR-146a, 155, 181a, and 223 in the OA patients were significantly higher than those found in healthy controls. In the early stages of OA, miR-146a and 223 expressions were significantly higher than they were at later stages. There was a significant correlation between the expression of miR-223 and KS. This study demonstrated that high expression levels of miR-146a, 155, 181a, and 223 in the PBMCs of OA patients might be related to the pathogenesis of OA." -tissue_expression_up hsa-mir-155 Osteoarthritis 22006119 "The relative expression levels of miR-146a, 155, 181a, and 223 in the OA patients were significantly higher than those found in healthy controls. In the early stages of OA, miR-146a and 223 expressions were significantly higher than they were at later stages. There was a significant correlation between the expression of miR-223 and KS. This study demonstrated that high expression levels of miR-146a, 155, 181a, and 223 in the PBMCs of OA patients might be related to the pathogenesis of OA." -tissue_expression_up hsa-mir-181a-1 Osteoarthritis 22006119 "The relative expression levels of miR-146a, 155, 181a, and 223 in the OA patients were significantly higher than those found in healthy controls. In the early stages of OA, miR-146a and 223 expressions were significantly higher than they were at later stages. There was a significant correlation between the expression of miR-223 and KS. This study demonstrated that high expression levels of miR-146a, 155, 181a, and 223 in the PBMCs of OA patients might be related to the pathogenesis of OA." -tissue_expression_up hsa-mir-181a-2 Osteoarthritis 22006119 "The relative expression levels of miR-146a, 155, 181a, and 223 in the OA patients were significantly higher than those found in healthy controls. In the early stages of OA, miR-146a and 223 expressions were significantly higher than they were at later stages. There was a significant correlation between the expression of miR-223 and KS. This study demonstrated that high expression levels of miR-146a, 155, 181a, and 223 in the PBMCs of OA patients might be related to the pathogenesis of OA." -tissue_expression_up hsa-mir-223 Osteoarthritis 22006119 "The relative expression levels of miR-146a, 155, 181a, and 223 in the OA patients were significantly higher than those found in healthy controls. In the early stages of OA, miR-146a and 223 expressions were significantly higher than they were at later stages. There was a significant correlation between the expression of miR-223 and KS. This study demonstrated that high expression levels of miR-146a, 155, 181a, and 223 in the PBMCs of OA patients might be related to the pathogenesis of OA." -tissue_expression_up hsa-mir-100 Thyroid Neoplasms 22006248 "miR-100, miR-125b, miR-138, and miR-768-3p were overexpressed in malignant samples of follicular origin (P <0.001), and in Hurthle cell carcinoma samples alone (P < 0.01). Only miR-125b was significantly overexpressed in follicular carcinoma samples (P < .05)." -tissue_expression_up hsa-mir-125b-1 Thyroid Neoplasms 22006248 "miR-100, miR-125b, miR-138, and miR-768-3p were overexpressed in malignant samples of follicular origin (P < .001), and in Hurthle cell carcinoma samples alone (P < .01). Only miR-125b was significantly overexpressed in follicular carcinoma samples (P < .05)." -tissue_expression_up hsa-mir-125b-2 Thyroid Neoplasms 22006248 "miR-100, miR-125b, miR-138, and miR-768-3p were overexpressed in malignant samples of follicular origin (P < .001), and in Hurthle cell carcinoma samples alone (P < .01). Only miR-125b was significantly overexpressed in follicular carcinoma samples (P < .05)." -tissue_expression_up hsa-mir-138-1 Thyroid Neoplasms 22006248 "miR-100, miR-125b, miR-138, and miR-768-3p were overexpressed in malignant samples of follicular origin (P < .001), and in Hurthle cell carcinoma samples alone (P < .01). Only miR-125b was significantly overexpressed in follicular carcinoma samples (P < .05)." -tissue_expression_up hsa-mir-138-2 Thyroid Neoplasms 22006248 "miR-100, miR-125b, miR-138, and miR-768-3p were overexpressed in malignant samples of follicular origin (P < .001), and in Hurthle cell carcinoma samples alone (P < .01). Only miR-125b was significantly overexpressed in follicular carcinoma samples (P < .05)." -tissue_expression_up hsa-let-7a-1 "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-let-7a-2 "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-let-7a-3 "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-105-1 "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-105-2 "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-106a "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-10b "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-146a "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-148b "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-17 "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-182 "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-193a "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-196a-1 "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-196a-2 "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-205 "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-21 "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-210 "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-217 "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-222 "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-25 "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-29a "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-302b "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-302c "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-30a "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-34c "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-372 "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-376a-1 "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-376a-2 "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-379 "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-432 "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-450a-1 "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-450a-2 "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-450b "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-493 "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-508 "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-517c "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-519e "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-96 "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-98 "Carcinoma, Hepatocellular" 22027761 This miRNA was up-regulated in HepG2 cells treated with BJA32515. -tissue_expression_up hsa-mir-223 Rheumatoid Arthritis 22032299 miR-223 is overexpressed in T-lymphocytes of early rheumatoid arthritis patients. -tissue_expression_up hsa-mir-146a Sjogren Syndrome 22033216 "We found that both miR-146a and miR-146b, furthermore, the gene of TRAF6 were significantly overexpressed in the Sjogren's patients, whereas the expression of IRAK1 gene was significantly decreased." -tissue_expression_up hsa-mir-146b Sjogren Syndrome 22033216 "We found that both miR-146a and miR-146b, furthermore, the gene of TRAF6 were significantly overexpressed in the Sjogren's patients, whereas the expression of IRAK1 gene was significantly decreased." -tissue_expression_up hsa-mir-21 "Cardiomyopathy, Dilated" 22041329 "Levels of let-7i, miR-126, and miR-155 were lower in the DCM group than in the controls, whereas levels of miR-21 and TLR4 (both mRNA and protein) were higher in the DCM group than in the control group. Levels of let-7i were negatively correlated with TLR4 protein levels in all subjects. After a mean follow-up period of 509 days, 6 DCM patients (5.8%) had died due to a cardiac cause and 15 (14.6%) had developed heart failure. When patients with DCM were divided into tertiles according to let-7i levels, log-rank analysis showed that the DCM subgroup with low let-7i levels was associated with poor clinical outcomes (P = .02)." -tissue_expression_up hsa-mir-1300 Pancreatic Neoplasms 22042419 "Among aberrantly expressed 122 microRNAs in IPMN, miR-552, miR-25*, miR-183, miR-1300, miR-196a, miR-182*, and miR-30c-1* were consistently increased more than 3-fold." -tissue_expression_up hsa-mir-182 Pancreatic Neoplasms 22042419 "Among aberrantly expressed 122 microRNAs in IPMN, miR-552, miR-25*, miR-183, miR-1300, miR-196a, miR-182*, and miR-30c-1* were consistently increased more than 3-fold." -tissue_expression_up hsa-mir-183 Pancreatic Neoplasms 22042419 "Among aberrantly expressed 122 microRNAs in IPMN, miR-552, miR-25*, miR-183, miR-1300, miR-196a, miR-182*, and miR-30c-1* were consistently increased more than 3-fold." -tissue_expression_up hsa-mir-196a Pancreatic Neoplasms 22042419 "Among aberrantly expressed 122 microRNAs in IPMN, miR-552, miR-25*, miR-183, miR-1300, miR-196a, miR-182*, and miR-30c-1* were consistently increased more than 3-fold." -tissue_expression_up hsa-mir-25 Pancreatic Neoplasms 22042419 "Among aberrantly expressed 122 microRNAs in IPMN, miR-552, miR-25*, miR-183, miR-1300, miR-196a, miR-182*, and miR-30c-1* were consistently increased more than 3-fold." -tissue_expression_up hsa-mir-30c Pancreatic Neoplasms 22042419 "Among aberrantly expressed 122 microRNAs in IPMN, miR-552, miR-25*, miR-183, miR-1300, miR-196a, miR-182*, and miR-30c-1* were consistently increased more than 3-fold." -tissue_expression_up hsa-mir-552 Pancreatic Neoplasms 22042419 "Among aberrantly expressed 122 microRNAs in IPMN, miR-552, miR-25*, miR-183, miR-1300, miR-196a, miR-182*, and miR-30c-1* were consistently increased more than 3-fold." -tissue_expression_up hsa-mir-106b Periodontal Diseases 22043006 "Two microRNA species (miR-30e, miR-106b) were up-regulated in non-obese individuals with periodontal disease." -tissue_expression_up hsa-mir-18a Obesity 22043006 "Two microRNA species (miR-18a, miR-30e) were up-regulated among obese individuals with a healthy periodontium." -tissue_expression_up hsa-mir-30e Obesity 22043006 "Two microRNA species (miR-18a, miR-30e) were up-regulated among obese individuals with a healthy periodontium." -tissue_expression_up hsa-mir-30e Periodontal Diseases 22043006 "Two microRNA species (miR-30e, miR-106b) were up-regulated in non-obese individuals with periodontal disease." -tissue_expression_up hsa-mir-101 Colon Neoplasms 22043014 "The development of colonic inflammation in IL-10(-/-) mice was accompanied by upregulation in the expression of 10 miRNAs (miR-19a, miR-21, miR-31, miR-101, miR-223, miR-326, miR-142-3p, miR-142-5p, miR-146a, and miR-155)" -tissue_expression_up hsa-mir-142 Colon Neoplasms 22043014 "The development of colonic inflammation in IL-10(-/-) mice was accompanied by upregulation in the expression of 10 miRNAs (miR-19a, miR-21, miR-31, miR-101, miR-223, miR-326, miR-142-3p, miR-142-5p, miR-146a, and miR-155)" -tissue_expression_up hsa-mir-146a Colon Neoplasms 22043014 "The development of colonic inflammation in IL-10(-/-) mice was accompanied by upregulation in the expression of 10 miRNAs (miR-19a, miR-21, miR-31, miR-101, miR-223, miR-326, miR-142-3p, miR-142-5p, miR-146a, and miR-155)" -tissue_expression_up hsa-mir-155 Colon Neoplasms 22043014 "The development of colonic inflammation in IL-10(-/-) mice was accompanied by upregulation in the expression of 10 miRNAs (miR-19a, miR-21, miR-31, miR-101, miR-223, miR-326, miR-142-3p, miR-142-5p, miR-146a, and miR-155)" -tissue_expression_up hsa-mir-19a Colon Neoplasms 22043014 "The development of colonic inflammation in IL-10(-/-) mice was accompanied by upregulation in the expression of 10 miRNAs (miR-19a, miR-21, miR-31, miR-101, miR-223, miR-326, miR-142-3p, miR-142-5p, miR-146a, and miR-155)" -tissue_expression_up hsa-mir-21 Colon Neoplasms 22043014 "The development of colonic inflammation in IL-10(-/-) mice was accompanied by upregulation in the expression of 10 miRNAs (miR-19a, miR-21, miR-31, miR-101, miR-223, miR-326, miR-142-3p, miR-142-5p, miR-146a, and miR-155)" -tissue_expression_up hsa-mir-223 Colon Neoplasms 22043014 "The development of colonic inflammation in IL-10(-/-) mice was accompanied by upregulation in the expression of 10 miRNAs (miR-19a, miR-21, miR-31, miR-101, miR-223, miR-326, miR-142-3p, miR-142-5p, miR-146a, and miR-155)" -tissue_expression_up hsa-mir-31 Colon Neoplasms 22043014 "The development of colonic inflammation in IL-10(-/-) mice was accompanied by upregulation in the expression of 10 miRNAs (miR-19a, miR-21, miR-31, miR-101, miR-223, miR-326, miR-142-3p, miR-142-5p, miR-146a, and miR-155)" -tissue_expression_up hsa-mir-326 Colon Neoplasms 22043014 "The development of colonic inflammation in IL-10(-/-) mice was accompanied by upregulation in the expression of 10 miRNAs (miR-19a, miR-21, miR-31, miR-101, miR-223, miR-326, miR-142-3p, miR-142-5p, miR-146a, and miR-155)" -tissue_expression_up hsa-mir-210 "Carcinoma, Renal Cell" 22043236 "For miR-92a, and a striking inverse correlation with VHL mRNA levels was found. For the hypoxia-regulated miR-210, clear cell tumors showed significantly higher expression levels when compared to tumor of non-clear cell histology (9.90-fold vs. 1.36, p<0.001)." -tissue_expression_up hsa-mir-92a-1 "Carcinoma, Renal Cell" 22043236 "For miR-92a, and a striking inverse correlation with VHL mRNA levels was found. For the hypoxia-regulated miR-210, clear cell tumors showed significantly higher expression levels when compared to tumor of non-clear cell histology (9.90-fold vs. 1.36, p<0.001)." -tissue_expression_up hsa-mir-92a-2 "Carcinoma, Renal Cell" 22043236 "For miR-92a, and a striking inverse correlation with VHL mRNA levels was found. For the hypoxia-regulated miR-210, clear cell tumors showed significantly higher expression levels when compared to tumor of non-clear cell histology (9.90-fold vs. 1.36, p<0.001)." -tissue_expression_up hsa-mir-146a Creutzfeldt-Jakob Disease 22043907 "Upregulation of micro RNA-146a (miRNA-146a), a marker for inflammatory neurodegeneration, in sporadic Creutzfeldt-Jakob disease (sCJD) and Gerstmann-Straussler-Scheinker (GSS) syndrome." -tissue_expression_up hsa-mir-146a Gerstmann-Straussler-Scheinker Syndrome 22043907 "Upregulation of micro RNA-146a (miRNA-146a), a marker for inflammatory neurodegeneration, in sporadic Creutzfeldt-Jakob disease (sCJD) and Gerstmann-Straussler-Scheinker (GSS) syndrome." -tissue_expression_up hsa-mir-182 Prostate Neoplasms 22045813 The miR-183-96-182 cluster is overexpressed in prostate tissue and regulates zinc homeostasis in prostate cells. -tissue_expression_up hsa-mir-183 Prostate Neoplasms 22045813 The miR-183-96-182 cluster is overexpressed in prostate tissue and regulates zinc homeostasis in prostate cells. -tissue_expression_up hsa-mir-96 Prostate Neoplasms 22045813 The miR-183-96-182 cluster is overexpressed in prostate tissue and regulates zinc homeostasis in prostate cells. -tissue_expression_up hsa-mir-195 Gastric Neoplasms 22046085 "Three miRs, miR-451, miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P < 0.0002, 0.0027 and 0.0046 respectively). High expression of each miR was associated with poorer prognosis for both recurrence and survival. Using miR-451, the positive predictive value for non-recurrence was 100% (13/13)." -tissue_expression_up hsa-mir-199a-1 Gastric Neoplasms 22046085 "Three miRs, miR-451, miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P < 0.0002, 0.0027 and 0.0046 respectively). High expression of each miR was associated with poorer prognosis for both recurrence and survival. Using miR-451, the positive predictive value for non-recurrence was 100% (13/13)." -tissue_expression_up hsa-mir-199a-2 Gastric Neoplasms 22046085 "Three miRs, miR-451, miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P < 0.0002, 0.0027 and 0.0046 respectively). High expression of each miR was associated with poorer prognosis for both recurrence and survival. Using miR-451, the positive predictive value for non-recurrence was 100% (13/13)." -tissue_expression_up hsa-mir-451a Gastric Neoplasms 22046085 "Three miRs, miR-451, miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P < 0.0002, 0.0027 and 0.0046 respectively). High expression of each miR was associated with poorer prognosis for both recurrence and survival. Using miR-451, the positive predictive value for non-recurrence was 100% (13/13)." -tissue_expression_up hsa-mir-96 "Carcinoma, Lung, Non-Small-Cell" 22046296 hsa-mir-96 is significantly and consistently up-regulated in all 6 NSCLCs. -tissue_expression_up hsa-mir-135a-1 Ependymoma 22053178 overexpression -tissue_expression_up hsa-mir-135a-2 Ependymoma 22053178 overexpression -tissue_expression_up hsa-mir-17 Ependymoma 22053178 miR-17-5p: overexpression -tissue_expression_up hsa-mir-10b Breast Neoplasms 22057972 "High level of miR-21, miR-10b, and miR-31 expression in bilateral vs. unilateral breast carcinomas." -tissue_expression_up hsa-mir-21 Breast Neoplasms 22057972 "High level of miR-21, miR-10b, and miR-31 expression in bilateral vs. unilateral breast carcinomas." -tissue_expression_up hsa-mir-31 Breast Neoplasms 22057972 "High level of miR-21, miR-10b, and miR-31 expression in bilateral vs. unilateral breast carcinomas." -tissue_expression_up hsa-mir-3163 Glioblastoma 22074483 "Significantly deregulated miRNAs were miR-3163 (fold change 2.0, p = 0.05), miR-539 (fold change 0.5, p = 0.001), miR-1305 (fold change 0.5, p = 0.05), miR-1260 (fold change 0.5, p = 0.03) and let-7a (fold change 0.3, p = 0.02) after temozolomide treatment." -tissue_expression_up hsa-mir-31 "Carcinoma, Oral" 22083872 "Salivary miR-31 was significantly increased in patients with oral carcinoma at all clinical stages, including very small tumors. However, our preliminary analysis showed no increase of salivary miR-31in patients with oral verrucous leukoplakia relative to controls. The miR-31 was more abundant in saliva than in plasma, suggesting salivary miR-31 was a more sensitive marker for oral malignancy. After excision of oral carcinoma, salivary miR-31 was remarkably reduced, indicating that most of the upregulated salivary miR-31 came from tumor tissues." -tissue_expression_up hsa-mir-128-1 Multiple Sclerosis 22088562 "miR-128 and miR-27b were increased in naive and miR-340 in memory CD4(+) T cells from patients with multiple sclerosis, inhibiting Th2 cell development and favouring pro-inflammatory Th1 responses." -tissue_expression_up hsa-mir-128-2 Multiple Sclerosis 22088562 "miR-128 and miR-27b were increased in naive and miR-340 in memory CD4(+) T cells from patients with multiple sclerosis, inhibiting Th2 cell development and favouring pro-inflammatory Th1 responses." -tissue_expression_up hsa-mir-27b Multiple Sclerosis 22088562 "miR-128 and miR-27b were increased in naive and miR-340 in memory CD4(+) T cells from patients with multiple sclerosis, inhibiting Th2 cell development and favouring pro-inflammatory Th1 responses." -tissue_expression_up hsa-mir-192 Barrett Esophagus 22094011 "We demonstrated unequivocal statistically significant upregulation of two microRNAs (miR-192, 196a) and downregulation of miR-203 and positive miR-196a correlation with progression from intestinal metaplasia to adenocarcinoma compared to normal individuals." -tissue_expression_up hsa-mir-196a-1 Barrett Esophagus 22094011 "We demonstrated unequivocal statistically significant upregulation of two microRNAs (miR-192, 196a) and downregulation of miR-203 and positive miR-196a correlation with progression from intestinal metaplasia to adenocarcinoma compared to normal individuals." -tissue_expression_up hsa-mir-196a-2 Barrett Esophagus 22094011 "We demonstrated unequivocal statistically significant upregulation of two microRNAs (miR-192, 196a) and downregulation of miR-203 and positive miR-196a correlation with progression from intestinal metaplasia to adenocarcinoma compared to normal individuals." -tissue_expression_up hsa-mir-155 Breast Neoplasms 22105810 "The relative expression of miR-155 was significantly higher in breast cancer tissues than in corresponding nontumor tissues. High miR-155 expression was correlated with higher tumor grade, advanced tumor stage and lymph node metastasis (P=0.012, 0.001, and 0.003, respectively). Kaplan-Meier survival analysis indicated that the disease-free and overall survival rates of high miR-155 group were significantly lower than those of low miR-155 group (P=0.038 and 0.029, respectively). Multivariate analysis showed that high miR-155 expression was a poor prognostic factor (P=0.009). Furthermore, antisense targeting miR-155 could inhibit growth, induce cell arrest in G(0) /G(1) phase, enhance apoptosis, and increase radiosensitivity in breast cancer cells." -tissue_expression_up hsa-let-7a Pancreatic Neoplasms 22108826 "These effects were associated with decreased expression of EZH2 and increased expression of a panel of tumor-suppressive microRNAs (miRNA), including let-7a, b, c, d, miR-26a, miR-101, miR-146a, andmiR-200b, c that are typically lost in pancreatic cancer." -tissue_expression_up hsa-let-7b Pancreatic Neoplasms 22108826 "These effects were associated with decreased expression of EZH2 and increased expression of a panel of tumor-suppressive microRNAs (miRNA), including let-7a, b, c, d, miR-26a, miR-101, miR-146a, andmiR-200b, c that are typically lost in pancreatic cancer." -tissue_expression_up hsa-let-7c Pancreatic Neoplasms 22108826 "These effects were associated with decreased expression of EZH2 and increased expression of a panel of tumor-suppressive microRNAs (miRNA), including let-7a, b, c, d, miR-26a, miR-101, miR-146a, andmiR-200b, c that are typically lost in pancreatic cancer." -tissue_expression_up hsa-let-7d Pancreatic Neoplasms 22108826 "These effects were associated with decreased expression of EZH2 and increased expression of a panel of tumor-suppressive microRNAs (miRNA), including let-7a, b, c, d, miR-26a, miR-101, miR-146a, andmiR-200b, c that are typically lost in pancreatic cancer." -tissue_expression_up hsa-mir-101 Pancreatic Neoplasms 22108826 "These effects were associated with decreased expression of EZH2 and increased expression of a panel of tumor-suppressive microRNAs (miRNA), including let-7a, b, c, d, miR-26a, miR-101, miR-146a, andmiR-200b, c that are typically lost in pancreatic cancer." -tissue_expression_up hsa-mir-146a Pancreatic Neoplasms 22108826 "These effects were associated with decreased expression of EZH2 and increased expression of a panel of tumor-suppressive microRNAs (miRNA), including let-7a, b, c, d, miR-26a, miR-101, miR-146a, andmiR-200b, c that are typically lost in pancreatic cancer." -tissue_expression_up hsa-mir-200b Pancreatic Neoplasms 22108826 "These effects were associated with decreased expression of EZH2 and increased expression of a panel of tumor-suppressive microRNAs (miRNA), including let-7a, b, c, d, miR-26a, miR-101, miR-146a, andmiR-200b, c that are typically lost in pancreatic cancer." -tissue_expression_up hsa-mir-200c Pancreatic Neoplasms 22108826 "These effects were associated with decreased expression of EZH2 and increased expression of a panel of tumor-suppressive microRNAs (miRNA), including let-7a, b, c, d, miR-26a, miR-101, miR-146a, andmiR-200b, c that are typically lost in pancreatic cancer." -tissue_expression_up hsa-mir-26a Pancreatic Neoplasms 22108826 "These effects were associated with decreased expression of EZH2 and increased expression of a panel of tumor-suppressive microRNAs (miRNA), including let-7a, b, c, d, miR-26a, miR-101, miR-146a, andmiR-200b, c that are typically lost in pancreatic cancer." -tissue_expression_up hsa-mir-21 Pancreatic Neoplasms 22114136 "In the initial cohort of 48 PDAC (pancreatic ductal adenocarcinoma) patients, high expression of miR-21 (Hazard ratio (HR): 3.22, 95% Confidence Interval (CI):1.21-8.58) and reduced expression of miR-34a (HR 0.15, 95%CI: 0.06-0.37) and miR-30d (HR:0.30, 95%CI:0.12-0.79) were associated with poor overall survival following resection independent of clinical covariates. In a further validation set of 24 patients miR-21 and miR-34a expression again significantly correlated with overall survival (P = 0.031 and P = 0.001)." -tissue_expression_up hsa-mir-122 Hepatitis C Virus Infection 22114337 "A high level of miR122 was expressed by lentiviral vector into human liver cell lines at a level comparable to the endogenous level in Huh7 cells. Among the cell lines we examined, Hep3B cells stably expressing miR122 (Hep3B/miR122) exhibited a significant enhancement of HCVcc propagation. Surprisingly, the productions of infectious particles in Hep3B/miR122 cells upon infection with HCVcc were comparable to those in Huh7 cells. Furthermore, a line of cured cells established by elimination of HCV RNA from the Hep3B/miR122 replicon cells exhibited an enhanced expression of miR122 and a continuous increase of infectious titers of HCVcc in every passage." -tissue_expression_up hsa-mir-10b Pancreatic Neoplasms 22117151 "miR-10b is upregulated in pancreatic ductal adenocarcinoma and can be used as a diagnostic marker in endoscopic ultrasound-guided fine-needle aspiration biopsies of suspicious pancreatic lesions. In addition, miR-10b may be able to guide neoadjuvant gemcitabine-based chemoradiotherapy and predict metastatic-free survival and overall survival." -tissue_expression_up hsa-mir-221 Prostate Neoplasms 22117988 "The level of ARHI mRNA was significantly lower in aggressive compared with non-aggressive prostate cancer tissue samples. In contrast, microRNA 221 and 222 levels were significantly higher in aggressive compared with non-aggressive prostate cancer tissue samples." -tissue_expression_up hsa-mir-222 Prostate Neoplasms 22117988 "The level of ARHI mRNA was significantly lower in aggressive compared with non-aggressive prostate cancer tissue samples. In contrast, microRNA 221 and 222 levels were significantly higher in aggressive compared with non-aggressive prostate cancer tissue samples." -tissue_expression_up hsa-let-7a-1 Colorectal Carcinoma 22120473 "Increased expression of miR-21, mir-135a and miR-335 was associated with clinical progression of CRC (colorectal cancer), while miR-206 demonstrated an opposite trend. The levels of mir-21 did not associate with the expression of PTEN, an important tumour suppressor in CRC and one of many putative targets of miR-21, but interestingly was associated with stage of disease in the PTEN expressing tumours. Surprisingly, let7a, a KRAS-targeting miR, showed elevated expression in metastatic disease compared to normal mucosa or non-metastatic disease, and only in KRAS mutation positive tumors. Finally, a prognostic signature of miR 21,135a, 335, 206 and let-7a for detecting the presence of metastases had a specificity of 87% and sensitivity of 76% for the presence of metastases." -tissue_expression_up hsa-let-7a-2 Colorectal Carcinoma 22120473 "Increased expression of miR-21, mir-135a and miR-335 was associated with clinical progression of CRC (colorectal cancer), while miR-206 demonstrated an opposite trend. The levels of mir-21 did not associate with the expression of PTEN, an important tumour suppressor in CRC and one of many putative targets of miR-21, but interestingly was associated with stage of disease in the PTEN expressing tumours. Surprisingly, let7a, a KRAS-targeting miR, showed elevated expression in metastatic disease compared to normal mucosa or non-metastatic disease, and only in KRAS mutation positive tumors. Finally, a prognostic signature of miR 21,135a, 335, 206 and let-7a for detecting the presence of metastases had a specificity of 87% and sensitivity of 76% for the presence of metastases." -tissue_expression_up hsa-let-7a-3 Colorectal Carcinoma 22120473 "Increased expression of miR-21, mir-135a and miR-335 was associated with clinical progression of CRC (colorectal cancer), while miR-206 demonstrated an opposite trend. The levels of mir-21 did not associate with the expression of PTEN, an important tumour suppressor in CRC and one of many putative targets of miR-21, but interestingly was associated with stage of disease in the PTEN expressing tumours. Surprisingly, let7a, a KRAS-targeting miR, showed elevated expression in metastatic disease compared to normal mucosa or non-metastatic disease, and only in KRAS mutation positive tumors. Finally, a prognostic signature of miR 21,135a, 335, 206 and let-7a for detecting the presence of metastases had a specificity of 87% and sensitivity of 76% for the presence of metastases." -tissue_expression_up hsa-mir-135a-1 Colorectal Carcinoma 22120473 "Increased expression of miR-21, mir-135a and miR-335 was associated with clinical progression of CRC (colorectal cancer), while miR-206 demonstrated an opposite trend. The levels of mir-21 did not associate with the expression of PTEN, an important tumour suppressor in CRC and one of many putative targets of miR-21, but interestingly was associated with stage of disease in the PTEN expressing tumours. Surprisingly, let7a, a KRAS-targeting miR, showed elevated expression in metastatic disease compared to normal mucosa or non-metastatic disease, and only in KRAS mutation positive tumors. Finally, a prognostic signature of miR 21,135a, 335, 206 and let-7a for detecting the presence of metastases had a specificity of 87% and sensitivity of 76% for the presence of metastases." -tissue_expression_up hsa-mir-135a-2 Colorectal Carcinoma 22120473 "Increased expression of miR-21, mir-135a and miR-335 was associated with clinical progression of CRC (colorectal cancer), while miR-206 demonstrated an opposite trend. The levels of mir-21 did not associate with the expression of PTEN, an important tumour suppressor in CRC and one of many putative targets of miR-21, but interestingly was associated with stage of disease in the PTEN expressing tumours. Surprisingly, let7a, a KRAS-targeting miR, showed elevated expression in metastatic disease compared to normal mucosa or non-metastatic disease, and only in KRAS mutation positive tumors. Finally, a prognostic signature of miR 21,135a, 335, 206 and let-7a for detecting the presence of metastases had a specificity of 87% and sensitivity of 76% for the presence of metastases." -tissue_expression_up hsa-mir-21 Colorectal Carcinoma 22120473 "Increased expression of miR-21, mir-135a and miR-335 was associated with clinical progression of CRC (colorectal cancer), while miR-206 demonstrated an opposite trend. The levels of mir-21 did not associate with the expression of PTEN, an important tumour suppressor in CRC and one of many putative targets of miR-21, but interestingly was associated with stage of disease in the PTEN expressing tumours. Surprisingly, let7a, a KRAS-targeting miR, showed elevated expression in metastatic disease compared to normal mucosa or non-metastatic disease, and only in KRAS mutation positive tumors. Finally, a prognostic signature of miR 21,135a, 335, 206 and let-7a for detecting the presence of metastases had a specificity of 87% and sensitivity of 76% for the presence of metastases." -tissue_expression_up hsa-mir-335 Colorectal Carcinoma 22120473 "Increased expression of miR-21, mir-135a and miR-335 was associated with clinical progression of CRC (colorectal cancer), while miR-206 demonstrated an opposite trend. The levels of mir-21 did not associate with the expression of PTEN, an important tumour suppressor in CRC and one of many putative targets of miR-21, but interestingly was associated with stage of disease in the PTEN expressing tumours. Surprisingly, let7a, a KRAS-targeting miR, showed elevated expression in metastatic disease compared to normal mucosa or non-metastatic disease, and only in KRAS mutation positive tumors. Finally, a prognostic signature of miR 21,135a, 335, 206 and let-7a for detecting the presence of metastases had a specificity of 87% and sensitivity of 76% for the presence of metastases." -tissue_expression_up hsa-let-7a-1 Periodontitis 22128589 "Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones." -tissue_expression_up hsa-let-7a-2 Periodontitis 22128589 "Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones." -tissue_expression_up hsa-let-7a-3 Periodontitis 22128589 "Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones." -tissue_expression_up hsa-let-7c Periodontitis 22128589 "Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones." -tissue_expression_up hsa-mir-130a Periodontitis 22128589 "Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones." -tissue_expression_up hsa-mir-181b-1 Periodontitis 22128589 "Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones." -tissue_expression_up hsa-mir-181b-2 Periodontitis 22128589 "Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones." -tissue_expression_up hsa-mir-19b-1 Periodontitis 22128589 "Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones." -tissue_expression_up hsa-mir-19b-2 Periodontitis 22128589 "Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones." -tissue_expression_up hsa-mir-23a Periodontitis 22128589 "Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones." -tissue_expression_up hsa-mir-301a Periodontitis 22128589 "Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones." -tissue_expression_up hsa-mir-30a Periodontitis 22128589 "Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones." -tissue_expression_up hsa-mir-520d Periodontitis 22128589 "Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones." -tissue_expression_up hsa-mir-548a-1 Periodontitis 22128589 "Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones." -tissue_expression_up hsa-mir-548a-2 Periodontitis 22128589 "Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones." -tissue_expression_up hsa-mir-548a-3 Periodontitis 22128589 "Six miRNA genes, let-7a, let-7c, miR-130a, miR301a, miR-520d, and miR-548a, were up-regulated more than 8 fold compared to the healthy gingiva. miR-181b, miR-19b, miR-23a, miR-30a, miR-let7a, and miR-301a, were amplified successfully and increased much more in periodontitis gingivae than in healthy ones." -tissue_expression_up hsa-mir-206 Muscular Dystrophy 22129894 The expression of miR-206 is increased in muscular dystrophy. -tissue_expression_up hsa-mir-9-1 Melanoma 22131135 MicroRNA-9 up-regulates E-cadherin through inhibition of NF-kB1-Snail1 pathway in melanoma. -tissue_expression_up hsa-mir-21 Urinary Bladder Cancer 22133680 Nuclear and cytoplasmatic PDCD4 immunostaining decreased significantly with histopathological progression of the tumor (p<0001). Controls showed strong nuclear and cytoplasmatic immunohistochemical staining. MiR-21 up regulation in tissue corresponded to PDCD4 suppression. -tissue_expression_up hsa-mir-146a Lichen Planus 22139425 Increased miRNA-146a and miRNA-155 expressions in oral lichen planus. -tissue_expression_up hsa-mir-155 Lichen Planus 22139425 Increased miRNA-146a and miRNA-155 expressions in oral lichen planus. -tissue_expression_up hsa-mir-187 Gastric Neoplasms 22169097 "Genome-wide miRNA expression profiles followed with Real-Time quantitative RT-PCR (qRT-PCR) assays revealed that miR-187(*), miR-371-5p and miR-378 were significantly elevated in GC patients. Further validation indicated that miR-378 alone could yields a ROC curve area of 0.861 with 87.5% sensitivity and 70.73% specificity in discriminating GC patients from healthy controls." -tissue_expression_up hsa-mir-371a Gastric Neoplasms 22169097 "Genome-wide miRNA expression profiles followed with Real-Time quantitative RT-PCR (qRT-PCR) assays revealed that miR-187(*), miR-371-5p and miR-378 were significantly elevated in GC patients. Further validation indicated that miR-378 alone could yields a ROC curve area of 0.861 with 87.5% sensitivity and 70.73% specificity in discriminating GC patients from healthy controls." -tissue_expression_up hsa-mir-378a Gastric Neoplasms 22169097 "Genome-wide miRNA expression profiles followed with Real-Time quantitative RT-PCR (qRT-PCR) assays revealed that miR-187(*), miR-371-5p and miR-378 were significantly elevated in GC patients. Further validation indicated that miR-378 alone could yields a ROC curve area of 0.861 with 87.5% sensitivity and 70.73% specificity in discriminating GC patients from healthy controls." -tissue_expression_up hsa-mir-375 "Carcinoma, Lung, Small-Cell" 22172490 miR-375 is highly expressed and possibly transactivated by achaete-scute complex homolog 1 in small-cell lung cancer cells. -tissue_expression_up hsa-mir-1183 Rectal Neoplasms 22172905 "Microarray analysis selected 14 miRNAs as being differentially expressed in TRG1 patients, and 13 were confirmed by qRT-PCR: 11 miRNAs (miR-1183, miR-483-5p, miR-622, miR-125a-3p, miR-1224-5p, miR-188-5p, miR-1471, miR-671-5p, miR-1909, miR-630, miR-765) were significantly upregulated in TRG1 patients, 2 (miR-1274b, miR-720) were downexpressed. MiR-622 and miR-630 had a 100% sensitivity and specificity in selecting TRG1 cases." -tissue_expression_up hsa-mir-1224 Rectal Neoplasms 22172905 "Microarray analysis selected 14 miRNAs as being differentially expressed in TRG1 patients, and 13 were confirmed by qRT-PCR: 11 miRNAs (miR-1183, miR-483-5p, miR-622, miR-125a-3p, miR-1224-5p, miR-188-5p, miR-1471, miR-671-5p, miR-1909, miR-630, miR-765) were significantly upregulated in TRG1 patients, 2 (miR-1274b, miR-720) were downexpressed. MiR-622 and miR-630 had a 100% sensitivity and specificity in selecting TRG1 cases." -tissue_expression_up hsa-mir-125a Rectal Neoplasms 22172905 "Microarray analysis selected 14 miRNAs as being differentially expressed in TRG1 patients, and 13 were confirmed by qRT-PCR: 11 miRNAs (miR-1183, miR-483-5p, miR-622, miR-125a-3p, miR-1224-5p, miR-188-5p, miR-1471, miR-671-5p, miR-1909, miR-630, miR-765) were significantly upregulated in TRG1 patients, 2 (miR-1274b, miR-720) were downexpressed. MiR-622 and miR-630 had a 100% sensitivity and specificity in selecting TRG1 cases." -tissue_expression_up hsa-mir-1471 Rectal Neoplasms 22172905 "Microarray analysis selected 14 miRNAs as being differentially expressed in TRG1 patients, and 13 were confirmed by qRT-PCR: 11 miRNAs (miR-1183, miR-483-5p, miR-622, miR-125a-3p, miR-1224-5p, miR-188-5p, miR-1471, miR-671-5p, miR-1909, miR-630, miR-765) were significantly upregulated in TRG1 patients, 2 (miR-1274b, miR-720) were downexpressed. MiR-622 and miR-630 had a 100% sensitivity and specificity in selecting TRG1 cases." -tissue_expression_up hsa-mir-188 Rectal Neoplasms 22172905 "Microarray analysis selected 14 miRNAs as being differentially expressed in TRG1 patients, and 13 were confirmed by qRT-PCR: 11 miRNAs (miR-1183, miR-483-5p, miR-622, miR-125a-3p, miR-1224-5p, miR-188-5p, miR-1471, miR-671-5p, miR-1909, miR-630, miR-765) were significantly upregulated in TRG1 patients, 2 (miR-1274b, miR-720) were downexpressed. MiR-622 and miR-630 had a 100% sensitivity and specificity in selecting TRG1 cases." -tissue_expression_up hsa-mir-1909 Rectal Neoplasms 22172905 "Microarray analysis selected 14 miRNAs as being differentially expressed in TRG1 patients, and 13 were confirmed by qRT-PCR: 11 miRNAs (miR-1183, miR-483-5p, miR-622, miR-125a-3p, miR-1224-5p, miR-188-5p, miR-1471, miR-671-5p, miR-1909, miR-630, miR-765) were significantly upregulated in TRG1 patients, 2 (miR-1274b, miR-720) were downexpressed. MiR-622 and miR-630 had a 100% sensitivity and specificity in selecting TRG1 cases." -tissue_expression_up hsa-mir-483 Rectal Neoplasms 22172905 "Microarray analysis selected 14 miRNAs as being differentially expressed in TRG1 patients, and 13 were confirmed by qRT-PCR: 11 miRNAs (miR-1183, miR-483-5p, miR-622, miR-125a-3p, miR-1224-5p, miR-188-5p, miR-1471, miR-671-5p, miR-1909, miR-630, miR-765) were significantly upregulated in TRG1 patients, 2 (miR-1274b, miR-720) were downexpressed. MiR-622 and miR-630 had a 100% sensitivity and specificity in selecting TRG1 cases." -tissue_expression_up hsa-mir-622 Rectal Neoplasms 22172905 "Microarray analysis selected 14 miRNAs as being differentially expressed in TRG1 patients, and 13 were confirmed by qRT-PCR: 11 miRNAs (miR-1183, miR-483-5p, miR-622, miR-125a-3p, miR-1224-5p, miR-188-5p, miR-1471, miR-671-5p, miR-1909, miR-630, miR-765) were significantly upregulated in TRG1 patients, 2 (miR-1274b, miR-720) were downexpressed. MiR-622 and miR-630 had a 100% sensitivity and specificity in selecting TRG1 cases." -tissue_expression_up hsa-mir-630 Rectal Neoplasms 22172905 "Microarray analysis selected 14 miRNAs as being differentially expressed in TRG1 patients, and 13 were confirmed by qRT-PCR: 11 miRNAs (miR-1183, miR-483-5p, miR-622, miR-125a-3p, miR-1224-5p, miR-188-5p, miR-1471, miR-671-5p, miR-1909, miR-630, miR-765) were significantly upregulated in TRG1 patients, 2 (miR-1274b, miR-720) were downexpressed. MiR-622 and miR-630 had a 100% sensitivity and specificity in selecting TRG1 cases." -tissue_expression_up hsa-mir-671 Rectal Neoplasms 22172905 "Microarray analysis selected 14 miRNAs as being differentially expressed in TRG1 patients, and 13 were confirmed by qRT-PCR: 11 miRNAs (miR-1183, miR-483-5p, miR-622, miR-125a-3p, miR-1224-5p, miR-188-5p, miR-1471, miR-671-5p, miR-1909, miR-630, miR-765) were significantly upregulated in TRG1 patients, 2 (miR-1274b, miR-720) were downexpressed. MiR-622 and miR-630 had a 100% sensitivity and specificity in selecting TRG1 cases." -tissue_expression_up hsa-mir-765 Rectal Neoplasms 22172905 "Microarray analysis selected 14 miRNAs as being differentially expressed in TRG1 patients, and 13 were confirmed by qRT-PCR: 11 miRNAs (miR-1183, miR-483-5p, miR-622, miR-125a-3p, miR-1224-5p, miR-188-5p, miR-1471, miR-671-5p, miR-1909, miR-630, miR-765) were significantly upregulated in TRG1 patients, 2 (miR-1274b, miR-720) were downexpressed. MiR-622 and miR-630 had a 100% sensitivity and specificity in selecting TRG1 cases." -tissue_expression_up hsa-mir-192 Colon Neoplasms 22180714 "Compared with expression in SW1116 cells, 35 miRNAs (including hsa-miR-192, hsa-miR-29b, hsa-miR-215, hsa-miR-194, hsa-miR-33a and hsa-miR-32) were upregulated more than 1.5-fold, and 11 miRNAs (including hsa-miR-93, hsa-miR-1231, hsa-miRPlus-F1080, hsa-miR-524-3p, hsa-miR-886-3p and hsa-miR-561) were downregulated in SW1116csc." -tissue_expression_up hsa-mir-194 Colon Neoplasms 22180714 "Compared with expression in SW1116 cells, 35 miRNAs (including hsa-miR-192, hsa-miR-29b, hsa-miR-215, hsa-miR-194, hsa-miR-33a and hsa-miR-32) were upregulated more than 1.5-fold, and 11 miRNAs (including hsa-miR-93, hsa-miR-1231, hsa-miRPlus-F1080, hsa-miR-524-3p, hsa-miR-886-3p and hsa-miR-561) were downregulated in SW1116csc." -tissue_expression_up hsa-mir-215 Colon Neoplasms 22180714 "Compared with expression in SW1116 cells, 35 miRNAs (including hsa-miR-192, hsa-miR-29b, hsa-miR-215, hsa-miR-194, hsa-miR-33a and hsa-miR-32) were upregulated more than 1.5-fold, and 11 miRNAs (including hsa-miR-93, hsa-miR-1231, hsa-miRPlus-F1080, hsa-miR-524-3p, hsa-miR-886-3p and hsa-miR-561) were downregulated in SW1116csc." -tissue_expression_up hsa-mir-29b Colon Neoplasms 22180714 "Compared with expression in SW1116 cells, 35 miRNAs (including hsa-miR-192, hsa-miR-29b, hsa-miR-215, hsa-miR-194, hsa-miR-33a and hsa-miR-32) were upregulated more than 1.5-fold, and 11 miRNAs (including hsa-miR-93, hsa-miR-1231, hsa-miRPlus-F1080, hsa-miR-524-3p, hsa-miR-886-3p and hsa-miR-561) were downregulated in SW1116csc." -tissue_expression_up hsa-mir-32 Colon Neoplasms 22180714 "Compared with expression in SW1116 cells, 35 miRNAs (including hsa-miR-192, hsa-miR-29b, hsa-miR-215, hsa-miR-194, hsa-miR-33a and hsa-miR-32) were upregulated more than 1.5-fold, and 11 miRNAs (including hsa-miR-93, hsa-miR-1231, hsa-miRPlus-F1080, hsa-miR-524-3p, hsa-miR-886-3p and hsa-miR-561) were downregulated in SW1116csc." -tissue_expression_up hsa-mir-33a Colon Neoplasms 22180714 "Compared with expression in SW1116 cells, 35 miRNAs (including hsa-miR-192, hsa-miR-29b, hsa-miR-215, hsa-miR-194, hsa-miR-33a and hsa-miR-32) were upregulated more than 1.5-fold, and 11 miRNAs (including hsa-miR-93, hsa-miR-1231, hsa-miRPlus-F1080, hsa-miR-524-3p, hsa-miR-886-3p and hsa-miR-561) were downregulated in SW1116csc." -tissue_expression_up hsa-mir-155 Down Syndrome 22182977 "a screening of micro-RNA (miRNA) from Down's syndrome brain and peripheral tissues indicated an upregulation of a chromosome 21-encoded miRNA-155 and a decrease in the abundance of the miRNA-155 mRNA target complement factor H (CFH), an important repressor of the innate immune response." -tissue_expression_up hsa-mir-7-1 "Allergic Rhinitis,Perennial" 22185732 up-regulated -tissue_expression_up hsa-mir-7-2 "Allergic Rhinitis,Perennial" 22185732 up-regulated -tissue_expression_up hsa-mir-7-3 "Allergic Rhinitis,Perennial" 22185732 up-regulated -tissue_expression_up hsa-mir-21 Urinary Bladder Cancer 22194833 mir-21 expression increased with worsening clinical diagnosis but that mir-143 was not correlated with histology. These observations were in stark contrast to previous reports involving cervical cancer cell lines in which mir-143 was consistently down-regulated but mir-21 largely unaffected. -tissue_expression_up hsa-mir-192 Diabetic Nephropathy 22211842 "TGF-beta1 activates Smad3 to regulate microRNAs that mediate renal fibrosis. Of them, miR-21 and miR-192 are upregulated but miR-29 and miR-200 families are downregulated." -tissue_expression_up hsa-mir-21 Diabetic Nephropathy 22211842 "TGF-beta1 activates Smad3 to regulate microRNAs that mediate renal fibrosis. Of them, miR-21 and miR-192 are upregulated but miR-29 and miR-200 families are downregulated." -tissue_expression_up hsa-mir-122 "Carcinoma, Hepatocellular" 22213236 up-regulated in HCC tissues.correlated with cirrhosis -tissue_expression_up hsa-mir-21 "Carcinoma, Hepatocellular" 22213236 up-regulated in HCC tissues.correlated with cirrhosis;associated with tumor stage and poor prognosis. -tissue_expression_up hsa-mir-221 "Carcinoma, Hepatocellular" 22213236 up-regulated in HCC tissues.correlated with cirrhosis;associated with tumor stage and poor prognosis. -tissue_expression_up hsa-mir-222 "Carcinoma, Hepatocellular" 22213236 up-regulated in HCC tissues. -tissue_expression_up hsa-mir-31 "Carcinoma, Hepatocellular" 22213236 up-regulated in HCC tissues.correlated with cirrhosis -tissue_expression_up hsa-mir-155 Pancreatic Neoplasms 22213426 "We found over-expression of miR-21, miR-221, miR-27a, miR-27b, and miR-155, and down-regulation of miR-216a,miR-216b, miR-217, and miR-146a expression in tumors derived from KC and KCI mouse model" -tissue_expression_up hsa-mir-21 Pancreatic Neoplasms 22213426 "We found over-expression of miR-21, miR-221, miR-27a, miR-27b, and miR-155, and down-regulation of miR-216a,miR-216b, miR-217, and miR-146a expression in tumors derived from KC and KCI mouse model" -tissue_expression_up hsa-mir-221 Pancreatic Neoplasms 22213426 "We found over-expression of miR-21, miR-221, miR-27a, miR-27b, and miR-155, and down-regulation of miR-216a,miR-216b, miR-217, and miR-146a expression in tumors derived from KC and KCI mouse model" -tissue_expression_up hsa-mir-27a Pancreatic Neoplasms 22213426 "We found over-expression of miR-21, miR-221, miR-27a, miR-27b, and miR-155, and down-regulation of miR-216a,miR-216b, miR-217, and miR-146a expression in tumors derived from KC and KCI mouse model" -tissue_expression_up hsa-mir-27b Pancreatic Neoplasms 22213426 "We found over-expression of miR-21, miR-221, miR-27a, miR-27b, and miR-155, and down-regulation of miR-216a,miR-216b, miR-217, and miR-146a expression in tumors derived from KC and KCI mouse model" -tissue_expression_up hsa-mir-483 "Diabetes Mellitus, Type 2" 22223106 "Increased miR-483-3p expression in vivo, programmed by early-life nutrition, limits storage of lipids in adipose tissue, causing lipotoxicity and insulin resistance and thus increasing susceptibility to metabolic disease." -tissue_expression_up hsa-mir-155 "Leukemia, Lymphocytic, Chronic, B-Cell" 22238073 SOCS1 is significantly up-regulated in Nutlin-3-treated p53(wild-type) B chronic lymphocytic leukemia (B-CLL) samples and shows an inverse correlation with miR-155. -tissue_expression_up hsa-mir-107 Prostate Neoplasms 22240788 miR-107 and miR-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls. -tissue_expression_up hsa-mir-574 Prostate Neoplasms 22240788 miR-107 and miR-574-3p were quantified at significantly higher concentrations in the urine of men with prostate cancer compared with controls. -tissue_expression_up hsa-mir-101-1 Pheochromocytoma 22241719 "miR-483-5p, miR-183, and miR-101 had significantly higher expression in malignant tumors as compared to their benign counterparts." -tissue_expression_up hsa-mir-101-2 Pheochromocytoma 22241719 "miR-483-5p, miR-183, and miR-101 had significantly higher expression in malignant tumors as compared to their benign counterparts." -tissue_expression_up hsa-mir-183 Pheochromocytoma 22241719 "miR-483-5p, miR-183, and miR-101 had significantly higher expression in malignant tumors as compared to their benign counterparts." -tissue_expression_up hsa-mir-483 Pheochromocytoma 22241719 "miR-483-5p, miR-183, and miR-101 had significantly higher expression in malignant tumors as compared to their benign counterparts." -tissue_expression_up hsa-mir-221 Liver Cirrhosis 22267590 MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis. -tissue_expression_up hsa-mir-222 Liver Cirrhosis 22267590 MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis. -tissue_expression_up hsa-let-7a-1 Cholesteatoma 22289526 "Levels of miR-21 and let-7a microRNA were significantly higher in cholesteatoma tissue compared with normal skin, especially in paediatric patients." -tissue_expression_up hsa-let-7a-2 Cholesteatoma 22289526 "Levels of miR-21 and let-7a microRNA were significantly higher in cholesteatoma tissue compared with normal skin, especially in paediatric patients." -tissue_expression_up hsa-let-7a-3 Cholesteatoma 22289526 "Levels of miR-21 and let-7a microRNA were significantly higher in cholesteatoma tissue compared with normal skin, especially in paediatric patients." -tissue_expression_up hsa-mir-21 Cholesteatoma 22289526 "Levels of miR-21 and let-7a microRNA were significantly higher in cholesteatoma tissue compared with normal skin, especially in paediatric patients." -tissue_expression_up hsa-mir-21 Colorectal Carcinoma 22289545 There was a significantly higher level of miR-21 in CRC tumour tissue than in NAT and high expression of miR-21 was significantly correlated with advanced clinical stage and poor cell differentiation. -tissue_expression_up hsa-mir-200a Breast Neoplasms 22294488 The miRNA-200 family and miRNA-9 exhibit differential expression in primary versus corresponding metastatic tissue in breast cancer. -tissue_expression_up hsa-mir-200b Breast Neoplasms 22294488 The miRNA-200 family and miRNA-9 exhibit differential expression in primary versus corresponding metastatic tissue in breast cancer. -tissue_expression_up hsa-mir-200c Breast Neoplasms 22294488 The miRNA-200 family and miRNA-9 exhibit differential expression in primary versus corresponding metastatic tissue in breast cancer. -tissue_expression_up hsa-mir-9-1 Breast Neoplasms 22294488 The miRNA-200 family and miRNA-9 exhibit differential expression in primary versus corresponding metastatic tissue in breast cancer. -tissue_expression_up hsa-mir-9-2 Breast Neoplasms 22294488 The miRNA-200 family and miRNA-9 exhibit differential expression in primary versus corresponding metastatic tissue in breast cancer. -tissue_expression_up hsa-mir-9-3 Breast Neoplasms 22294488 The miRNA-200 family and miRNA-9 exhibit differential expression in primary versus corresponding metastatic tissue in breast cancer. -tissue_expression_up hsa-mir-145 Prostate Neoplasms 22298119 Significantly increased miR-145 expression were observed for patients with intermediate or high risk D'Amico scores compared to patients with low risk scores -tissue_expression_up hsa-mir-20a Prostate Neoplasms 22298119 miR-20a was significantly overexpressed in plasma from patients with stage 3 tumors compared to stage 2 or below (P=0.03). -tissue_expression_up hsa-mir-21 Prostate Neoplasms 22298119 The expression levels for miR-20a and miR-21 were significantly increased in patients with high risk CAPRA scores -tissue_expression_up hsa-mir-21 Laryngeal Neoplasms 22320969 "Mir-21 was up-regulated in LSCCs and HSCCs compared to adjacent non-tumor tissues (P < 0.05), and the up-regulated expression of mir-21 was associated with clinical stage (P = 0.001), T classification (P = 0.007), pathologic differentiation (P = 0.025), and lymph node positivity (P = 0.002)." -tissue_expression_up hsa-mir-21 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 22320969 "Mir-21 was up-regulated in LSCCs (laryngeal squamous cell carcinomas) and HSCCs(hypopharyngeal squamous cell carcinomas) compared to adjacent non-tumor tissues (P < 0.05), and the up-regulated expression of mir-21 was associated with clinical stage (P = 0.001), T classification (P = 0.007), pathologic differentiation (P = 0.025), and lymph node positivity (P = 0.002)." -tissue_expression_up hsa-mir-210 Breast Neoplasms 22323552 High Expression of MicroRNA-210 is an Independent Factor Indicating a Poor Prognosis in Japanese Triple-negative Breast Cancer Patients. -tissue_expression_up hsa-mir-21 Breast Neoplasms 22323912 "High miR-21 expression was associated with mastectomy, larger tumor size, higher stage, higher grade, estrogen receptor (ER) negative, human epidermal growth factor receptor 2 (HER2) positive, HER2 positive breast cancer subtype, high Ki-67 expression, and death." -tissue_expression_up hsa-mir-1-1 Myocardial Infarction 22330002 "MiR-1, -21 -133a and -423-5p showed a 3- to 10-fold increase and miR-499-5p exhibited >80-fold increase in acute NSTEMI patient vs. CTR." -tissue_expression_up hsa-mir-1-2 Myocardial Infarction 22330002 "MiR-1, -21 -133a and -423-5p showed a 3- to 10-fold increase and miR-499-5p exhibited >80-fold increase in acute NSTEMI patient vs. CTR." -tissue_expression_up hsa-mir-133a-1 Myocardial Infarction 22330002 "MiR-1, -21 -133a and -423-5p showed a 3- to 10-fold increase and miR-499-5p exhibited >80-fold increase in acute NSTEMI patient vs. CTR." -tissue_expression_up hsa-mir-133a-2 Myocardial Infarction 22330002 "MiR-1, -21 -133a and -423-5p showed a 3- to 10-fold increase and miR-499-5p exhibited >80-fold increase in acute NSTEMI patient vs. CTR." -tissue_expression_up hsa-mir-21 Myocardial Infarction 22330002 "MiR-1, -21 -133a and -423-5p showed a 3- to 10-fold increase and miR-499-5p exhibited >80-fold increase in acute NSTEMI patient vs. CTR." -tissue_expression_up hsa-mir-423 Myocardial Infarction 22330002 "MiR-1, -21 -133a and -423-5p showed a 3- to 10-fold increase and miR-499-5p exhibited >80-fold increase in acute NSTEMI patient vs. CTR." -tissue_expression_up hsa-mir-21 Glioma 22335906 miR-21 was up-regulated 1.49-fold in SHG-44(R) cells (Radioresistant cell line) relative to the SHG-44 cells. -tissue_expression_up hsa-mir-34b Ovarian Neoplasms 22340095 "The expressions of miR-449a/b, miR-34b and miR-34c were 19-fold to 21-fold elevated after p53 activation by genotoxic agent adriamycin." -tissue_expression_up hsa-mir-34c Ovarian Neoplasms 22340095 "The expressions of miR-449a/b, miR-34b and miR-34c were 19-fold to 21-fold elevated after p53 activation by genotoxic agent adriamycin." -tissue_expression_up hsa-mir-449a Ovarian Neoplasms 22340095 "The expressions of miR-449a/b, miR-34b and miR-34c were 19-fold to 21-fold elevated after p53 activation by genotoxic agent adriamycin." -tissue_expression_up hsa-mir-449b Ovarian Neoplasms 22340095 "The expressions of miR-449a/b, miR-34b and miR-34c were 19-fold to 21-fold elevated after p53 activation by genotoxic agent adriamycin." -tissue_expression_up hsa-mir-182 "Lymphoma, Hodgkin" 22343918 "In cHL cell lines FOXO1 is inactivated by multiple mechanisms, including constitutive activation of AKT/PKB and MAPK/ERK kinases and up-regulation of microRNAs miR-96, miR-182, and miR-183." -tissue_expression_up hsa-mir-183 "Lymphoma, Hodgkin" 22343918 "In cHL cell lines FOXO1 is inactivated by multiple mechanisms, including constitutive activation of AKT/PKB and MAPK/ERK kinases and up-regulation of microRNAs miR-96, miR-182, and miR-183." -tissue_expression_up hsa-mir-96 "Lymphoma, Hodgkin" 22343918 "In cHL cell lines FOXO1 is inactivated by multiple mechanisms, including constitutive activation of AKT/PKB and MAPK/ERK kinases and up-regulation of microRNAs miR-96, miR-182, and miR-183." -tissue_expression_up hsa-mir-148b Ovarian Neoplasms 22344713 "miR-148b was overexpressed in 92.21% (71/77) of the ovarian cancer samples examined, and overexpression of miR-148b in ovarian cancer tissues was not associated with any of the clinicopathological features of patients with ovarian cancer." -tissue_expression_up hsa-mir-181a-1 Osteosarcoma 22350417 high expression -tissue_expression_up hsa-mir-181a-2 Osteosarcoma 22350417 high expression -tissue_expression_up hsa-mir-181b-1 Osteosarcoma 22350417 high expression -tissue_expression_up hsa-mir-181b-2 Osteosarcoma 22350417 high expression -tissue_expression_up hsa-mir-181c Osteosarcoma 22350417 high expression -tissue_expression_up hsa-mir-125b-1 Glioma 22360855 "The levels of miRNA-125b and MMP9 were significantly higher in SU3 and SU2, also a highly invasive GSCPs we established before, than in U251s." -tissue_expression_up hsa-mir-663a Burns 22360957 miR-663 was up-regulated in denatured dermis compared with those in normal skin. -tissue_expression_up hsa-mir-206 Prolactinoma 22366961 miR-206 was significantly up-regulated in prolactinomas following bromocriptine treatment. -tissue_expression_up hsa-mir-516b-1 Prolactinoma 22366961 miR-516b was significantly up-regulated in prolactinomas following bromocriptine treatment. -tissue_expression_up hsa-mir-516b-2 Prolactinoma 22366961 miR-516b was significantly up-regulated in prolactinomas following bromocriptine treatment. -tissue_expression_up hsa-mir-550a-1 Prolactinoma 22366961 miR-516b was significantly up-regulated in prolactinomas following bromocriptine treatment. -tissue_expression_up hsa-mir-550a-2 Prolactinoma 22366961 miR-550 was significantly up-regulated in prolactinomas following bromocriptine treatment. -tissue_expression_up hsa-mir-671 Prolactinoma 22366961 miR-671-5p was significantly up-regulated in prolactinomas following bromocriptine treatment. -tissue_expression_up hsa-mir-21 Gastric Neoplasms 22374783 "Real-time RT-PCR analysis demonstrated an increase in mir-21 and mir-302 expression level in CSCs(cancer stem cells), relative to cancer cells, whereas let-7a expression level was decreased in CSC in comparison with cancer cells. mir-372, mir-373 and mir-520c-5p were markedly increased in cancer cells in comparison with CSCs." -tissue_expression_up hsa-mir-302a Gastric Neoplasms 22374783 "Real-time RT-PCR analysis demonstrated an increase in mir-21 and mir-302 expression level in CSCs(cancer stem cells), relative to cancer cells, whereas let-7a expression level was decreased in CSC in comparison with cancer cells. mir-372, mir-373 and mir-520c-5p were markedly increased in cancer cells in comparison with CSCs." -tissue_expression_up hsa-mir-302b Gastric Neoplasms 22374783 "Real-time RT-PCR analysis demonstrated an increase in mir-21 and mir-302 expression level in CSCs(cancer stem cells), relative to cancer cells, whereas let-7a expression level was decreased in CSC in comparison with cancer cells. mir-372, mir-373 and mir-520c-5p were markedly increased in cancer cells in comparison with CSCs." -tissue_expression_up hsa-mir-302c Gastric Neoplasms 22374783 "Real-time RT-PCR analysis demonstrated an increase in mir-21 and mir-302 expression level in CSCs(cancer stem cells), relative to cancer cells, whereas let-7a expression level was decreased in CSC in comparison with cancer cells. mir-372, mir-373 and mir-520c-5p were markedly increased in cancer cells in comparison with CSCs." -tissue_expression_up hsa-mir-302d Gastric Neoplasms 22374783 "Real-time RT-PCR analysis demonstrated an increase in mir-21 and mir-302 expression level in CSCs(cancer stem cells), relative to cancer cells, whereas let-7a expression level was decreased in CSC in comparison with cancer cells. mir-372, mir-373 and mir-520c-5p were markedly increased in cancer cells in comparison with CSCs." -tissue_expression_up hsa-mir-302e Gastric Neoplasms 22374783 "Real-time RT-PCR analysis demonstrated an increase in mir-21 and mir-302 expression level in CSCs(cancer stem cells), relative to cancer cells, whereas let-7a expression level was decreased in CSC in comparison with cancer cells. mir-372, mir-373 and mir-520c-5p were markedly increased in cancer cells in comparison with CSCs." -tissue_expression_up hsa-mir-302f Gastric Neoplasms 22374783 "Real-time RT-PCR analysis demonstrated an increase in mir-21 and mir-302 expression level in CSCs(cancer stem cells), relative to cancer cells, whereas let-7a expression level was decreased in CSC in comparison with cancer cells. mir-372, mir-373 and mir-520c-5p were markedly increased in cancer cells in comparison with CSCs." -tissue_expression_up hsa-mir-372 Gastric Neoplasms 22374783 "Real-time RT-PCR analysis demonstrated an increase in mir-21 and mir-302 expression level in CSCs(cancer stem cells), relative to cancer cells, whereas let-7a expression level was decreased in CSC in comparison with cancer cells. mir-372, mir-373 and mir-520c-5p were markedly increased in cancer cells in comparison with CSCs." -tissue_expression_up hsa-mir-373 Gastric Neoplasms 22374783 "Real-time RT-PCR analysis demonstrated an increase in mir-21 and mir-302 expression level in CSCs(cancer stem cells), relative to cancer cells, whereas let-7a expression level was decreased in CSC in comparison with cancer cells. mir-372, mir-373 and mir-520c-5p were markedly increased in cancer cells in comparison with CSCs." -tissue_expression_up hsa-mir-520c Gastric Neoplasms 22374783 "Real-time RT-PCR analysis demonstrated an increase in mir-21 and mir-302 expression level in CSCs(cancer stem cells), relative to cancer cells, whereas let-7a expression level was decreased in CSC in comparison with cancer cells. mir-372, mir-373 and mir-520c-5p were markedly increased in cancer cells in comparison with CSCs." -tissue_expression_up hsa-mir-20a Glioma 22381757 The glioma tissues showed significantly up-regulated expression of miR-20a compared with normal brain tissues (P=0.035). The expression level of miR-20a was higher in high-grade than in low-grade gliomas. miR-20a mimics significantly enhanced the proliferation of U251 cells and the percentage of S-phase cells. -tissue_expression_up hsa-mir-19b-1 Colon Neoplasms 22382630 "In response to 5-FU, miR-19b and miR-21 were over-expressed in 5-FU-resistant cells." -tissue_expression_up hsa-mir-19b-2 Colon Neoplasms 22382630 "In response to 5-FU, miR-19b and miR-21 were over-expressed in 5-FU-resistant cells." -tissue_expression_up hsa-mir-21 Colorectal Carcinoma 22382630 "In response to 5-FU, miR-19b and miR-21 were over-expressed in 5-FU-resistant cells." -tissue_expression_up hsa-mir-199a-1 Chronic Obstructive Pulmonary Disease 22383663 "miR-34a and miR-199a-5p expression was increased and the phosphorylation of AKT was decreased in COPD lungs. The miR-199a-5p expression was correlated with HIF-1§Ø©ãprotein expression in COPD patient's lungs. Transfection of HPMVEC with the miR-199a-5p precursor gene decreased HIF-1§Ø©ãprotein expression, and transfection with the miR-34a precursor gene increased miR-199a-5p expression." -tissue_expression_up hsa-mir-34a Chronic Obstructive Pulmonary Disease 22383663 "miR-34a and miR-199a-5p expression was increased and the phosphorylation of AKT was decreased in COPD lungs. The miR-199a-5p expression was correlated with HIF-1§Ø©ãprotein expression in COPD patient's lungs. Transfection of HPMVEC with the miR-199a-5p precursor gene decreased HIF-1§Ø©ãprotein expression, and transfection with the miR-34a precursor gene increased miR-199a-5p expression." -tissue_expression_up hsa-mir-155 Urinary Bladder Cancer 22386240 "Compared with controls, the patients with bladder cancer had a lower expression of the miR-200 family, miR-192, and miR-155 in the urinary sediment; lower expression of miR-192; and higher expression of miR-155 in the urinary supernatant." -tissue_expression_up hsa-mir-708 Bladder Neoplasms 22393979 Differential miRNA expression profiles in bladder urothelial carcinomas identified miR-100 down-regulation and miR-708 up-regulation among the most common alterations -tissue_expression_up hsa-mir-126 Colorectal Carcinoma 22397399 The median miRNA-126 expression level was significantly higher in patients responding to XELOX (capecitabine and oxaliplatin). -tissue_expression_up hsa-mir-638 Breast Neoplasms 22403704 "Treatment with E2, BPA and DDT decreased (p<0.05) miR-21 expression. Several members of the let-7 family (let-7a, let-7b, let-7c, let-7d, let-7e and let-7f), were downregulated (p<0.05) by all three treatments.and miR-15b (p<0.005) and miR-27b (p<0.01) were also downregulated by the three treatments.upregulation of miR-638 (P<0.005), miR-663 (P<0.005), and miR-1915 (P<0.005) was observed after treatment of MCF7 cells with E2, BPA or DDT" -tissue_expression_up hsa-mir-663a Breast Neoplasms 22403704 "Treatment with E2, BPA and DDT decreased (p<0.05) miR-21 expression. Several members of the let-7 family (let-7a, let-7b, let-7c, let-7d, let-7e and let-7f), were downregulated (p<0.05) by all three treatments.and miR-15b (p<0.005) and miR-27b (p<0.01) were also downregulated by the three treatments.upregulation of miR-638 (P<0.005), miR-663 (P<0.005), and miR-1915 (P<0.005) was observed after treatment of MCF7 cells with E2, BPA or DDT" -tissue_expression_up hsa-mir-107 Gastric Neoplasms 22407237 "In the analysis by real-time PCR-based miRNA arrays using pooled RNA samples from five gastric cancer patients, expression of miR-107, miR-21, miR-196a, miR-26b, miR-9, miR-142-3p, miR-30b, miR-150, miR-191 and miR-17 was found to be upregulation.miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. In Kaplan-Meier survival curve analysis, overall survival rates (OS) and disease-free survival rates (DFS) of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression. In the Cox multivariate analysis, it was shown that miR-107 expression in gastric cancer tissues was an independent prognostic factor for OS and DFS. Significant inverse correlations were demonstrated between miR-107 and DICER1 mRNA. Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients." -tissue_expression_up hsa-mir-142 Gastric Neoplasms 22407237 "In the analysis by real-time PCR-based miRNA arrays using pooled RNA samples from five gastric cancer patients, expression of miR-107, miR-21, miR-196a, miR-26b, miR-9, miR-142-3p, miR-30b, miR-150, miR-191 and miR-17 was found to be upregulation.miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. In Kaplan-Meier survival curve analysis, overall survival rates (OS) and disease-free survival rates (DFS) of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression. In the Cox multivariate analysis, it was shown that miR-107 expression in gastric cancer tissues was an independent prognostic factor for OS and DFS. Significant inverse correlations were demonstrated between miR-107 and DICER1 mRNA. Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients." -tissue_expression_up hsa-mir-150 Gastric Neoplasms 22407237 "In the analysis by real-time PCR-based miRNA arrays using pooled RNA samples from five gastric cancer patients, expression of miR-107, miR-21, miR-196a, miR-26b, miR-9, miR-142-3p, miR-30b, miR-150, miR-191 and miR-17 was found to be upregulation.miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. In Kaplan-Meier survival curve analysis, overall survival rates (OS) and disease-free survival rates (DFS) of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression. In the Cox multivariate analysis, it was shown that miR-107 expression in gastric cancer tissues was an independent prognostic factor for OS and DFS. Significant inverse correlations were demonstrated between miR-107 and DICER1 mRNA. Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients." -tissue_expression_up hsa-mir-17 Gastric Neoplasms 22407237 "In the analysis by real-time PCR-based miRNA arrays using pooled RNA samples from five gastric cancer patients, expression of miR-107, miR-21, miR-196a, miR-26b, miR-9, miR-142-3p, miR-30b, miR-150, miR-191 and miR-17 was found to be upregulation.miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. In Kaplan-Meier survival curve analysis, overall survival rates (OS) and disease-free survival rates (DFS) of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression. In the Cox multivariate analysis, it was shown that miR-107 expression in gastric cancer tissues was an independent prognostic factor for OS and DFS. Significant inverse correlations were demonstrated between miR-107 and DICER1 mRNA. Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients." -tissue_expression_up hsa-mir-191 Gastric Neoplasms 22407237 "In the analysis by real-time PCR-based miRNA arrays using pooled RNA samples from five gastric cancer patients, expression of miR-107, miR-21, miR-196a, miR-26b, miR-9, miR-142-3p, miR-30b, miR-150, miR-191 and miR-17 was found to be upregulation.miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. In Kaplan-Meier survival curve analysis, overall survival rates (OS) and disease-free survival rates (DFS) of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression. In the Cox multivariate analysis, it was shown that miR-107 expression in gastric cancer tissues was an independent prognostic factor for OS and DFS. Significant inverse correlations were demonstrated between miR-107 and DICER1 mRNA. Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients." -tissue_expression_up hsa-mir-196a-1 Gastric Neoplasms 22407237 "In the analysis by real-time PCR-based miRNA arrays using pooled RNA samples from five gastric cancer patients, expression of miR-107, miR-21, miR-196a, miR-26b, miR-9, miR-142-3p, miR-30b, miR-150, miR-191 and miR-17 was found to be upregulation.miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. In Kaplan-Meier survival curve analysis, overall survival rates (OS) and disease-free survival rates (DFS) of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression. In the Cox multivariate analysis, it was shown that miR-107 expression in gastric cancer tissues was an independent prognostic factor for OS and DFS. Significant inverse correlations were demonstrated between miR-107 and DICER1 mRNA. Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients." -tissue_expression_up hsa-mir-196a-2 Gastric Neoplasms 22407237 "In the analysis by real-time PCR-based miRNA arrays using pooled RNA samples from five gastric cancer patients, expression of miR-107, miR-21, miR-196a, miR-26b, miR-9, miR-142-3p, miR-30b, miR-150, miR-191 and miR-17 was found to be upregulation.miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. In Kaplan-Meier survival curve analysis, overall survival rates (OS) and disease-free survival rates (DFS) of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression. In the Cox multivariate analysis, it was shown that miR-107 expression in gastric cancer tissues was an independent prognostic factor for OS and DFS. Significant inverse correlations were demonstrated between miR-107 and DICER1 mRNA. Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients." -tissue_expression_up hsa-mir-21 Gastric Neoplasms 22407237 "In the analysis by real-time PCR-based miRNA arrays using pooled RNA samples from five gastric cancer patients, expression of miR-107, miR-21, miR-196a, miR-26b, miR-9, miR-142-3p, miR-30b, miR-150, miR-191 and miR-17 was found to be upregulation.miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. In Kaplan-Meier survival curve analysis, overall survival rates (OS) and disease-free survival rates (DFS) of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression. In the Cox multivariate analysis, it was shown that miR-107 expression in gastric cancer tissues was an independent prognostic factor for OS and DFS. Significant inverse correlations were demonstrated between miR-107 and DICER1 mRNA. Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients." -tissue_expression_up hsa-mir-26b Gastric Neoplasms 22407237 "In the analysis by real-time PCR-based miRNA arrays using pooled RNA samples from five gastric cancer patients, expression of miR-107, miR-21, miR-196a, miR-26b, miR-9, miR-142-3p, miR-30b, miR-150, miR-191 and miR-17 was found to be upregulation.miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. In Kaplan-Meier survival curve analysis, overall survival rates (OS) and disease-free survival rates (DFS) of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression. In the Cox multivariate analysis, it was shown that miR-107 expression in gastric cancer tissues was an independent prognostic factor for OS and DFS. Significant inverse correlations were demonstrated between miR-107 and DICER1 mRNA. Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients." -tissue_expression_up hsa-mir-30b Gastric Neoplasms 22407237 "In the analysis by real-time PCR-based miRNA arrays using pooled RNA samples from five gastric cancer patients, expression of miR-107, miR-21, miR-196a, miR-26b, miR-9, miR-142-3p, miR-30b, miR-150, miR-191 and miR-17 was found to be upregulation.miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. In Kaplan-Meier survival curve analysis, overall survival rates (OS) and disease-free survival rates (DFS) of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression. In the Cox multivariate analysis, it was shown that miR-107 expression in gastric cancer tissues was an independent prognostic factor for OS and DFS. Significant inverse correlations were demonstrated between miR-107 and DICER1 mRNA. Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients." -tissue_expression_up hsa-mir-9-1 Gastric Neoplasms 22407237 "In the analysis by real-time PCR-based miRNA arrays using pooled RNA samples from five gastric cancer patients, expression of miR-107, miR-21, miR-196a, miR-26b, miR-9, miR-142-3p, miR-30b, miR-150, miR-191 and miR-17 was found to be upregulation.miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. In Kaplan-Meier survival curve analysis, overall survival rates (OS) and disease-free survival rates (DFS) of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression. In the Cox multivariate analysis, it was shown that miR-107 expression in gastric cancer tissues was an independent prognostic factor for OS and DFS. Significant inverse correlations were demonstrated between miR-107 and DICER1 mRNA. Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients." -tissue_expression_up hsa-mir-9-2 Gastric Neoplasms 22407237 "In the analysis by real-time PCR-based miRNA arrays using pooled RNA samples from five gastric cancer patients, expression of miR-107, miR-21, miR-196a, miR-26b, miR-9, miR-142-3p, miR-30b, miR-150, miR-191 and miR-17 was found to be upregulation.miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. In Kaplan-Meier survival curve analysis, overall survival rates (OS) and disease-free survival rates (DFS) of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression. In the Cox multivariate analysis, it was shown that miR-107 expression in gastric cancer tissues was an independent prognostic factor for OS and DFS. Significant inverse correlations were demonstrated between miR-107 and DICER1 mRNA. Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients." -tissue_expression_up hsa-mir-9-3 Gastric Neoplasms 22407237 "In the analysis by real-time PCR-based miRNA arrays using pooled RNA samples from five gastric cancer patients, expression of miR-107, miR-21, miR-196a, miR-26b, miR-9, miR-142-3p, miR-30b, miR-150, miR-191 and miR-17 was found to be upregulation.miR-107 expression showed significant association with depth of tumor invasion, lymph node metastasis and stage. In Kaplan-Meier survival curve analysis, overall survival rates (OS) and disease-free survival rates (DFS) of patients with high miR-107 expression were significantly worse than those of patients with low miR-107 expression. In the Cox multivariate analysis, it was shown that miR-107 expression in gastric cancer tissues was an independent prognostic factor for OS and DFS. Significant inverse correlations were demonstrated between miR-107 and DICER1 mRNA. Our results indicate that miR-107 may be useful as an effective biomarker for prediction of a poor prognosis in gastric cancer patients." -tissue_expression_up hsa-mir-155 Graft-Versus-Host Disease 22408260 miR-155 up-regulation was shown in specimens from patients with pathological evidence of intestinal aGVHD (Acute graft-versus-host disease). -tissue_expression_up hsa-mir-26a-1 Multiple Endocrine Neoplasia Type 1 22409234 "The authors found that in hADSCs the siRNA-induced silencing of MEN1 mRNA resulted in a down regulation of miR-26a, with a consequent up-regulation of SMAD1 protein." -tissue_expression_up hsa-mir-26a-2 Multiple Endocrine Neoplasia Type 1 22409234 "The authors found that in hADSCs the siRNA-induced silencing of MEN1 mRNA resulted in a down regulation of miR-26a, with a consequent up-regulation of SMAD1 protein." -tissue_expression_up hsa-mir-21 Psoriasis 22417311 MiR-21 is up-regulated in psoriasis and suppresses T cell apoptosis. -tissue_expression_up hsa-mir-196a-1 Gastric Neoplasms 22420029 "The expression level of miR-196a microRNA significantly increased in primary gastric cancer tissues versus adjacent normal tissues. In addition, extracellular miR-196a detected in conditioned medium was strongly correlated with its cellular expression status and increased circulating miR-196a in patient serum was associated with gastric cancer disease status and relapse." -tissue_expression_up hsa-mir-196a-2 Gastric Neoplasms 22420029 "The expression level of miR-196a microRNA significantly increased in primary gastric cancer tissues versus adjacent normal tissues. In addition, extracellular miR-196a detected in conditioned medium was strongly correlated with its cellular expression status and increased circulating miR-196a in patient serum was associated with gastric cancer disease status and relapse." -tissue_expression_up hsa-mir-130b Head And Neck Neoplasms 22425712 up-regulation -tissue_expression_up hsa-mir-155 Head And Neck Neoplasms 22425712 up-regulation -tissue_expression_up hsa-mir-21 Head And Neck Neoplasms 22425712 up-regulation -tissue_expression_up hsa-mir-223 Head And Neck Neoplasms 22425712 up-regulation -tissue_expression_up hsa-mir-31 Head And Neck Neoplasms 22425712 up-regulation -tissue_expression_up hsa-mir-29a Colon Neoplasms 22426940 "High expression of miR-29a was associated with a longer disease-free survival (DFS) for patients with stage 2 colon cancer, on both univariate and multivariate analyses." -tissue_expression_up hsa-mir-216a Heart Failure 22427379 "miR-216a was strongly increased in both D-HF (diabetic HF) and ND-HF (nondiabetic HF) patients, negatively correlated with left ventricular ejection fraction." -tissue_expression_up hsa-mir-106a Gastric Neoplasms 22431000 miR-106a Is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS. -tissue_expression_up hsa-mir-34a "Carcinoma, Lung, Non-Small-Cell" 22438124 Delta-tocotrienol suppresses Notch-1 pathway by up-regulating miR-34a in non-small cell lung cancer cells. -tissue_expression_up hsa-mir-15a Leukemia 22449094 Pure curcumin decreases the expression of WT1 by upregulation of miR-15a and miR-16-1 in leukemic cells. -tissue_expression_up hsa-mir-16-1 Leukemia 22449094 Pure curcumin decreases the expression of WT1 by upregulation of miR-15a and miR-16-1 in leukemic cells. -tissue_expression_up hsa-mir-16-2 Leukemia 22449094 Pure curcumin decreases the expression of WT1 by upregulation of miR-15a and miR-16-1 in leukemic cells. -tissue_expression_up hsa-mir-101-2 Gastric Neoplasms 22450781 Lack of microRNA-101 causes E-cadherin functional deregulation through EZH2 upregulation in intestinal gastric cancer. -tissue_expression_up hsa-mir-100 Pancreatic Neoplasms 22466166 "Carcinomas showed higher expression of miR-21, miR-221, miR-155, miR-100, and miR-181b than benign lesions. Cellblocks containing carcinoma showed higher expression of miR-21, miR-221, and miR-196a than those from benign lesions." -tissue_expression_up hsa-mir-155 Pancreatic Neoplasms 22466166 "Carcinomas showed higher expression of miR-21, miR-221, miR-155, miR-100, and miR-181b than benign lesions. Cellblocks containing carcinoma showed higher expression of miR-21, miR-221, and miR-196a than those from benign lesions." -tissue_expression_up hsa-mir-181b-1 Pancreatic Neoplasms 22466166 "Carcinomas showed higher expression of miR-21, miR-221, miR-155, miR-100, and miR-181b than benign lesions. Cellblocks containing carcinoma showed higher expression of miR-21, miR-221, and miR-196a than those from benign lesions." -tissue_expression_up hsa-mir-181b-2 Pancreatic Neoplasms 22466166 "Carcinomas showed higher expression of miR-21, miR-221, miR-155, miR-100, and miR-181b than benign lesions. Cellblocks containing carcinoma showed higher expression of miR-21, miR-221, and miR-196a than those from benign lesions." -tissue_expression_up hsa-mir-196a-1 Pancreatic Neoplasms 22466166 "Carcinomas showed higher expression of miR-21, miR-221, miR-155, miR-100, and miR-181b than benign lesions. Cellblocks containing carcinoma showed higher expression of miR-21, miR-221, and miR-196a than those from benign lesions." -tissue_expression_up hsa-mir-196a-2 Pancreatic Neoplasms 22466166 "Carcinomas showed higher expression of miR-21, miR-221, miR-155, miR-100, and miR-181b than benign lesions. Cellblocks containing carcinoma showed higher expression of miR-21, miR-221, and miR-196a than those from benign lesions." -tissue_expression_up hsa-mir-21 Pancreatic Neoplasms 22466166 "Carcinomas showed higher expression of miR-21, miR-221, miR-155, miR-100, and miR-181b than benign lesions. Cellblocks containing carcinoma showed higher expression of miR-21, miR-221, and miR-196a than those from benign lesions." -tissue_expression_up hsa-mir-221 Pancreatic Neoplasms 22466166 "Carcinomas showed higher expression of miR-21, miR-221, miR-155, miR-100, and miR-181b than benign lesions. Cellblocks containing carcinoma showed higher expression of miR-21, miR-221, and miR-196a than those from benign lesions." -tissue_expression_up hsa-mir-424 Urinary Bladder Cancer 22469983 Suppressed miR-424 expression via upregulation of target gene Chk1 contributes to the progression of cervical cancer. -tissue_expression_up hsa-mir-21 Colorectal Carcinoma 22476768 Kaplan-Meier analysis proved that the miR-21 expression levels are correlated to shorter overall survival of CRC patients. -tissue_expression_up hsa-mir-151a Breast Neoplasms 22489664 miR-151-5p upregulation may suppress metastasis in primary breast tumors. -tissue_expression_up hsa-mir-151b Breast Neoplasms 22489664 miR-151-5p upregulation may suppress metastasis in primary breast tumors. -tissue_expression_up hsa-mir-23b Prolactinoma 22490835 up-regulated -tissue_expression_up hsa-mir-342 Prolactinoma 22490835 miR-342-3p: up-regulated -tissue_expression_up hsa-mir-432 Prolactinoma 22490835 up-regulated -tissue_expression_up hsa-mir-493 Prolactinoma 22490835 up-regulated -tissue_expression_up hsa-mir-664 Prolactinoma 22490835 miR-664*: up-regulated -tissue_expression_up hsa-mir-10b Breast Neoplasms 22492962 "The levels of miR-10b and miR-21 are found significantly increased in the CSF (cerebrospinal fluid) of patients with glioblastoma and brain metastasis of breast and lung cancer, compared with tumors in remission and a variety of nonneoplastic conditions." -tissue_expression_up hsa-mir-10b Glioblastoma 22492962 "The levels of miR-10b and miR-21 are found significantly increased in the CSF (cerebrospinal fluid) of patients with glioblastoma and brain metastasis of breast and lung cancer, compared with tumors in remission and a variety of nonneoplastic conditions." -tissue_expression_up hsa-mir-10b Lung Neoplasms 22492962 "The levels of miR-10b and miR-21 are found significantly increased in the CSF (cerebrospinal fluid) of patients with glioblastoma and brain metastasis of breast and lung cancer, compared with tumors in remission and a variety of nonneoplastic conditions." -tissue_expression_up hsa-mir-21 Breast Neoplasms 22492962 "The levels of miR-10b and miR-21 are found significantly increased in the CSF (cerebrospinal fluid) of patients with glioblastoma and brain metastasis of breast and lung cancer, compared with tumors in remission and a variety of nonneoplastic conditions." -tissue_expression_up hsa-mir-21 Glioblastoma 22492962 "The levels of miR-10b and miR-21 are found significantly increased in the CSF (cerebrospinal fluid) of patients with glioblastoma and brain metastasis of breast and lung cancer, compared with tumors in remission and a variety of nonneoplastic conditions." -tissue_expression_up hsa-mir-21 Lung Neoplasms 22492962 "The levels of miR-10b and miR-21 are found significantly increased in the CSF (cerebrospinal fluid) of patients with glioblastoma and brain metastasis of breast and lung cancer, compared with tumors in remission and a variety of nonneoplastic conditions." -tissue_expression_up hsa-mir-34a Neuroblastoma 22498172 "Combination of 4-HPR (N-(4-hydroxyphenyl) retinamide) and EGCG ((-)-epigallocatechin-3-gallate) most significantly decreased expression of OGmiRs (miR-92, miR-93, and miR-106b) and increased expression of TSmiRs (miR-7-1, miR-34a, and miR-99a) in both cell lines(SK-N-BE2 and IMR-32 cells)" -tissue_expression_up hsa-mir-7-1 Neuroblastoma 22498172 "Combination of 4-HPR (N-(4-hydroxyphenyl) retinamide) and EGCG ((-)-epigallocatechin-3-gallate) most significantly decreased expression of OGmiRs (miR-92, miR-93, and miR-106b) and increased expression of TSmiRs (miR-7-1, miR-34a, and miR-99a) in both cell lines(SK-N-BE2 and IMR-32 cells)" -tissue_expression_up hsa-mir-99a Neuroblastoma 22498172 "Combination of 4-HPR (N-(4-hydroxyphenyl) retinamide) and EGCG ((-)-epigallocatechin-3-gallate) most significantly decreased expression of OGmiRs (miR-92, miR-93, and miR-106b) and increased expression of TSmiRs (miR-7-1, miR-34a, and miR-99a) in both cell lines(SK-N-BE2 and IMR-32 cells)" -tissue_expression_up hsa-mir-146a Osteoarthritis 22507670 "IL-1¦Â responsive miR-146a is overexpressed in an experimentally induced OA model, accompanied by upregulation of VEGF and downregulation of Smad4 in vivo." -tissue_expression_up hsa-mir-200c Endometrial Neoplasms 22514717 The expression levels of miR-200c (P<0.0001) and miR-205 (P<0.0001) were significantly increased in endometrial tumors compared to normal tissues. Kaplan-Meier survival analysis revealed that high levels of miR-205 expression were associated with poor patient overall survival. -tissue_expression_up hsa-mir-205 Endometrial Neoplasms 22514717 The expression levels of miR-200c (P<0.0001) and miR-205 (P<0.0001) were significantly increased in endometrial tumors compared to normal tissues. Kaplan-Meier survival analysis revealed that high levels of miR-205 expression were associated with poor patient overall survival. -tissue_expression_up hsa-mir-155 Demyelinating Diseases 22517757 "Both in vivo and in vitro, myelin antigen stimulation resulted in significant up-regulation of miR-301a, miR-21, and miR-155." -tissue_expression_up hsa-mir-21 Demyelinating Diseases 22517757 "Both in vivo and in vitro, myelin antigen stimulation resulted in significant up-regulation of miR-301a, miR-21, and miR-155." -tissue_expression_up hsa-mir-132 "Liver Diseases, Alcoholic" 22518321 "In this paper, we summarize the current knowledge of miRNAs in ALD and also report increased expression of miR-155 and miR-132 in the total liver as well as in isolated hepatocytes and KCs of alcohol-fed mice." -tissue_expression_up hsa-mir-155 "Liver Diseases, Alcoholic" 22518321 "In this paper, we summarize the current knowledge of miRNAs in ALD and also report increased expression of miR-155 and miR-132 in the total liver as well as in isolated hepatocytes and KCs of alcohol-fed mice." -tissue_expression_up hsa-mir-125b-1 Breast Neoplasms 22523546 "miR-125b was significantly associated with therapeutic response, exhibiting higher expression level in non-responsive patients." -tissue_expression_up hsa-mir-125b-2 Breast Neoplasms 22523546 "miR-125b was significantly associated with therapeutic response, exhibiting higher expression level in non-responsive patients." -tissue_expression_up hsa-mir-10a Breast Neoplasms 22524830 "The BC patients showed an up-regulation in miRNAs (mir-155, mir-10,mir-21 and mir-373)" -tissue_expression_up hsa-mir-10b Breast Neoplasms 22524830 "The BC patients showed an up-regulation in miRNAs (mir-155, mir-10,mir-21 and mir-373)" -tissue_expression_up hsa-mir-155 Breast Neoplasms 22524830 "The BC patients showed an up-regulation in miRNAs (mir-155, mir-10,mir-21 and mir-373)" -tissue_expression_up hsa-mir-21 Breast Neoplasms 22524830 "The BC patients showed an up-regulation in miRNAs (mir-155, mir-10,mir-21 and mir-373)" -tissue_expression_up hsa-mir-373 Breast Neoplasms 22524830 "The BC patients showed an up-regulation in miRNAs (mir-155, mir-10,mir-21 and mir-373)" -tissue_expression_up hsa-mir-155 Endometrial Neoplasms 22525818 miR-155 was over-expressed and AGTR1 was underexpressed in endometrial carcinoma tissues. -tissue_expression_up hsa-mir-106b "Carcinoma, Basal Cell" 22540308 upregulated in the tumor center -tissue_expression_up hsa-mir-125a "Carcinoma, Basal Cell" 22540308 miR-125a-5p is upregulated in the tumor center -tissue_expression_up hsa-mir-17 "Carcinoma, Basal Cell" 22540308 upregulated in the tumor center -tissue_expression_up hsa-mir-181c "Carcinoma, Basal Cell" 22540308 miR-181c and miR-181c* are upregulated in the tumor center -tissue_expression_up hsa-mir-181d "Carcinoma, Basal Cell" 22540308 upregulated in the tumor center -tissue_expression_up hsa-mir-182 "Carcinoma, Basal Cell" 22540308 upregulated in the tumor center -tissue_expression_up hsa-mir-18a "Carcinoma, Basal Cell" 22540308 upregulated in the tumor center -tissue_expression_up hsa-mir-18b "Carcinoma, Basal Cell" 22540308 upregulated in the tumor center -tissue_expression_up hsa-mir-19b-1 "Carcinoma, Basal Cell" 22540308 miR-19b is upregulated in the tumor center -tissue_expression_up hsa-mir-19b-2 "Carcinoma, Basal Cell" 22540308 miR-19b is upregulated in the tumor center -tissue_expression_up hsa-mir-455 "Carcinoma, Basal Cell" 22540308 miR-455-5p and miR-455-3p are upregulated in the tumor center -tissue_expression_up hsa-mir-542 "Carcinoma, Basal Cell" 22540308 miR-542 is upregulated in the tumor center -tissue_expression_up hsa-mir-93 "Carcinoma, Basal Cell" 22540308 upregulated in the tumor center -tissue_expression_up hsa-mir-30b "Squamous Cell Carcinoma, Oral" 22542163 Amplification and up-regulation of microRNA-30b in oral squamous cell cancers. -tissue_expression_up hsa-mir-142 Endometrial Neoplasms 22543862 miR-142-5p: Increased expression after Progesterone Treatment. -tissue_expression_up hsa-mir-146b Endometrial Neoplasms 22543862 miR-146b-5p: Increased expression after Progesterone Treatment. -tissue_expression_up hsa-mir-21 Endometrial Neoplasms 22543862 Increased expression after Progesterone Treatment. -tissue_expression_up hsa-mir-625 Endometrial Neoplasms 22543862 miR-625*: Increased expression after Progesterone Treatment. -tissue_expression_up hsa-mir-34a Colorectal Carcinoma 22562822 "microRNA-34a, microRNA-155 and microRNA-200c overexpression in human colorectal cancer." -tissue_expression_up hsa-mir-93 Gastric Neoplasms 22567743 "miR-93 is highly elevated in gastric cancer, especially in advanced and metastasized gastric cancer, suggesting miR-93 may play critical roles in carcinogenesis of gastric cancer. Overexpression of miR-93 can serve as a novel prognostic marker for gastric cancer." -tissue_expression_up hsa-mir-708 "Carcinoma, Lung, Non-Small-Cell" 22573352 Increased miR-708 expression in NSCLC and its association with poor survival in lung adenocarcinoma from never smokers. -tissue_expression_up hsa-mir-17 "Carcinoma, Hepatocellular" 22583011 miR-17-5p was significantly upregulated in HCCs. HCC with metastasis had higher miR-17-5p levels than that without metastasis. -tissue_expression_up hsa-mir-142 Atopic Dermatitis 22594804 "In humans sensitized with DPCP, we found significant upregulation of miR-21, miR-142-3p, miR-142-5p and miR-223 in challenged skin." -tissue_expression_up hsa-mir-21 Atopic Dermatitis 22594804 "In humans sensitized with DPCP, we found significant upregulation of miR-21, miR-142-3p, miR-142-5p and miR-223 in challenged skin." -tissue_expression_up hsa-mir-223 Atopic Dermatitis 22594804 "In humans sensitized with DPCP, we found significant upregulation of miR-21, miR-142-3p, miR-142-5p and miR-223 in challenged skin." -tissue_expression_up hsa-mir-150 Inflammation 22595106 "Of the 335 human miRNAs identified in the pulp tissues, 3 miRNAs, miR-150, miR-584, and miR-766, were significantly up-regulated in inflamed pulps as compared with normal pulps" -tissue_expression_up hsa-mir-584 Inflammation 22595106 "Of the 335 human miRNAs identified in the pulp tissues, 3 miRNAs, miR-150, miR-584, and miR-766, were significantly up-regulated in inflamed pulps as compared with normal pulps" -tissue_expression_up hsa-mir-766 Inflammation 22595106 "Of the 335 human miRNAs identified in the pulp tissues, 3 miRNAs, miR-150, miR-584, and miR-766, were significantly up-regulated in inflamed pulps as compared with normal pulps" -tissue_expression_up hsa-mir-205 Laryngeal Neoplasms 22605671 Upregulation -tissue_expression_up hsa-mir-21 Laryngeal Neoplasms 22605671 Upregulation -tissue_expression_up hsa-mir-708 Laryngeal Neoplasms 22605671 Upregulation -tissue_expression_up hsa-mir-93 Laryngeal Neoplasms 22605671 Upregulation -tissue_expression_up hsa-mir-221 Gastric Neoplasms 22613407 "MiR-221 was up-regulated in 88% (81/92) of gastric cancer tissue samples compared with their paired adjacent nontumour tissue samples. High expression of miR-221 showed a significant correlation with advanced tumour-node-metastasis stage, local invasion and lymphatic metastasis." -tissue_expression_up hsa-mir-130a Ovarian Neoplasms 22614869 Altered microRNA expression in cisplatin-resistant ovarian cancer cells and upregulation of miR-130a associated with MDR1/P-glycoprotein-mediated drug resistance. -tissue_expression_up hsa-mir-155 "Carcinoma, Hepatocellular" 22629365 "High expression levels of miR-155, miR-15a, miR-432, miR-486-3p, miR-15b and miR-30b were significantly associated with recurrence-free." -tissue_expression_up hsa-mir-15a "Carcinoma, Hepatocellular" 22629365 "High expression levels of miR-155, miR-15a, miR-432, miR-486-3p, miR-15b and miR-30b were significantly associated with recurrence-free." -tissue_expression_up hsa-mir-15b "Carcinoma, Hepatocellular" 22629365 "High expression levels of miR-155, miR-15a, miR-432, miR-486-3p, miR-15b and miR-30b were significantly associated with recurrence-free." -tissue_expression_up hsa-mir-30b "Carcinoma, Hepatocellular" 22629365 "High expression levels of miR-155, miR-15a, miR-432, miR-486-3p, miR-15b and miR-30b were significantly associated with recurrence-free." -tissue_expression_up hsa-mir-432 "Carcinoma, Hepatocellular" 22629365 "High expression levels of miR-155, miR-15a, miR-432, miR-486-3p, miR-15b and miR-30b were significantly associated with recurrence-free." -tissue_expression_up hsa-mir-486 "Carcinoma, Hepatocellular" 22629365 "High expression levels of miR-155, miR-15a, miR-432, miR-486-3p, miR-15b and miR-30b were significantly associated with recurrence-free." -tissue_expression_up hsa-mir-34a Head And Neck Neoplasms 22629428 Dysregulation of microRNA-34a expression in head and neck squamous cell carcinoma promotes tumor growth and tumor angiogenesis. -tissue_expression_up hsa-mir-21 Breast Neoplasms 22638884 "miR-21 was significantly overexpressed in human solid cancerous serum relative to normal control (P < 0.001), and its sensitivity and specificity were significantly higher than the currently used tumor markers." -tissue_expression_up hsa-mir-21 Colorectal Carcinoma 22638884 "miR-21 was significantly overexpressed in human solid cancerous serum relative to normal control (P < 0.001), and its sensitivity and specificity were significantly higher than the currently used tumor markers." -tissue_expression_up hsa-mir-21 Esophageal Neoplasms 22638884 "miR-21 was significantly overexpressed in human solid cancerous serum relative to normal control (P < 0.001), and its sensitivity and specificity were significantly higher than the currently used tumor markers." -tissue_expression_up hsa-mir-21 Gastric Neoplasms 22638884 "miR-21 was significantly overexpressed in human solid cancerous serum relative to normal control (P < 0.001), and its sensitivity and specificity were significantly higher than the currently used tumor markers." -tissue_expression_up hsa-mir-21 Lung Neoplasms 22638884 "miR-21 was significantly overexpressed in human solid cancerous serum relative to normal control (P < 0.001), and its sensitivity and specificity were significantly higher than the currently used tumor markers." -tissue_expression_up hsa-mir-181a-2 Colorectal Carcinoma 22641662 "KRAS up-regulates the expression of miR-181a, miR-200c and miR-210 in a three-dimensional-specific manner in DLD-1 colorectal cancer cells." -tissue_expression_up hsa-mir-200c Colorectal Carcinoma 22641662 "KRAS up-regulates the expression of miR-181a, miR-200c and miR-210 in a three-dimensional-specific manner in DLD-1 colorectal cancer cells." -tissue_expression_up hsa-mir-210 Colorectal Carcinoma 22641662 "KRAS up-regulates the expression of miR-181a, miR-200c and miR-210 in a three-dimensional-specific manner in DLD-1 colorectal cancer cells." -tissue_expression_up hsa-mir-146a Ovarian Neoplasms 22643117 "We found 37 differentially expressed miRNAs in the CD133(+) spheroid-forming subpopulation of OVCAR3 cells, 34 of which were significantly up-regulated, including miR-205, miR-146a, miR-200a, miR-200b, and miR-3, and 3 of which were significantly down-regulated, including miR-1202 and miR-1181." -tissue_expression_up hsa-mir-200a Ovarian Neoplasms 22643117 "We found 37 differentially expressed miRNAs in the CD133(+) spheroid-forming subpopulation of OVCAR3 cells, 34 of which were significantly up-regulated, including miR-205, miR-146a, miR-200a, miR-200b, and miR-3, and 3 of which were significantly down-regulated, including miR-1202 and miR-1181." -tissue_expression_up hsa-mir-200b Ovarian Neoplasms 22643117 "We found 37 differentially expressed miRNAs in the CD133(+) spheroid-forming subpopulation of OVCAR3 cells, 34 of which were significantly up-regulated, including miR-205, miR-146a, miR-200a, miR-200b, and miR-3, and 3 of which were significantly down-regulated, including miR-1202 and miR-1181." -tissue_expression_up hsa-mir-205 Ovarian Neoplasms 22643117 "We found 37 differentially expressed miRNAs in the CD133(+) spheroid-forming subpopulation of OVCAR3 cells, 34 of which were significantly up-regulated, including miR-205, miR-146a, miR-200a, miR-200b, and miR-3, and 3 of which were significantly down-regulated, including miR-1202 and miR-1181." -tissue_expression_up hsa-mir-3 Ovarian Neoplasms 22643117 "We found 37 differentially expressed miRNAs in the CD133(+) spheroid-forming subpopulation of OVCAR3 cells, 34 of which were significantly up-regulated, including miR-205, miR-146a, miR-200a, miR-200b, and miR-3, and 3 of which were significantly down-regulated, including miR-1202 and miR-1181." -tissue_expression_up hsa-mir-335 Glioma 22644918 Tumor microRNA-335 expression is associated with poor prognosis in human glioma. -tissue_expression_up hsa-mir-92a-1 "Scleroderma, Systemic" 22661558 microRNA-92a expression in the sera and dermal fibroblasts increases in patients with scleroderma. -tissue_expression_up hsa-mir-92a-2 "Scleroderma, Systemic" 22661558 microRNA-92a expression in the sera and dermal fibroblasts increases in patients with scleroderma. -tissue_expression_up hsa-mir-182 Lung Neoplasms 22672859 "Four up-regulated microRNAs (miR-210, miR-21, miR-31 and miR-182) and two down-regulated mcroiRNAs (miR-126 and miR-145) were consistently reported both in squamous carcinoma and adenocarcinoma-based subgroup analysis" -tissue_expression_up hsa-mir-21 Lung Neoplasms 22672859 "Four up-regulated microRNAs (miR-210, miR-21, miR-31 and miR-182) and two down-regulated mcroiRNAs (miR-126 and miR-145) were consistently reported both in squamous carcinoma and adenocarcinoma-based subgroup analysis" -tissue_expression_up hsa-mir-210 Lung Neoplasms 22672859 "Four up-regulated microRNAs (miR-210, miR-21, miR-31 and miR-182) and two down-regulated mcroiRNAs (miR-126 and miR-145) were consistently reported both in squamous carcinoma and adenocarcinoma-based subgroup analysis" -tissue_expression_up hsa-mir-31 Lung Neoplasms 22672859 "Four up-regulated microRNAs (miR-210, miR-21, miR-31 and miR-182) and two down-regulated mcroiRNAs (miR-126 and miR-145) were consistently reported both in squamous carcinoma and adenocarcinoma-based subgroup analysis" -tissue_expression_up hsa-mir-190a Meningioma 22674195 Downregulation of miR-29c-3p and miR-219-5p were found to be associated with advanced clinical stages of meningioma. Kaplan-Meier analysis showed that high expression of miR-190a and low expression of miR-29c-3p and miR-219-5p correlated significantly with higher recurrence rates in meningioma patients. -tissue_expression_up hsa-mir-221 Glioma 22681957 High level of miR-221/222 confers increased cell invasion and poor prognosis in glioma. -tissue_expression_up hsa-mir-222 Glioma 22681957 High level of miR-221/222 confers increased cell invasion and poor prognosis in glioma. -tissue_expression_up hsa-mir-17 Osteosarcoma 22682620 up-regulated in osteosarcoma. -tissue_expression_up hsa-mir-18a Osteosarcoma 22682620 up-regulated in osteosarcoma. -tissue_expression_up hsa-mir-19a Osteosarcoma 22682620 up-regulated in osteosarcoma. -tissue_expression_up hsa-mir-19b-1 Osteosarcoma 22682620 up-regulated in osteosarcoma. -tissue_expression_up hsa-mir-20a Osteosarcoma 22682620 up-regulated in osteosarcoma. -tissue_expression_up hsa-mir-92a-1 Osteosarcoma 22682620 up-regulated in osteosarcoma. -tissue_expression_up hsa-mir-134 Pancreatic Neoplasms 22690071 "miR-95, miR-134 and miR-34c-3p are the top three miRNAs regulated by glargine (3.65-fold, 2.67-fold and 2.60-fold changes respectively, P < 0.01) in Sw1990 cells." -tissue_expression_up hsa-mir-34c Pancreatic Neoplasms 22690071 "miR-95, miR-134 and miR-34c-3p are the top three miRNAs regulated by glargine (3.65-fold, 2.67-fold and 2.60-fold changes respectively, P < 0.01) in Sw1990 cells." -tissue_expression_up hsa-mir-95 Pancreatic Neoplasms 22690071 "miR-95, miR-134 and miR-34c-3p are the top three miRNAs regulated by glargine (3.65-fold, 2.67-fold and 2.60-fold changes respectively, P < 0.01) in Sw1990 cells." -tissue_expression_up hsa-mir-21 Urinary Bladder Cancer 22704449 High miR-21 expression correlated with worse overall patient survival (p = 0.0099). -tissue_expression_up hsa-mir-21 Melanoma 22716245 microRNA-21 is upregulated in malignant melanoma and influences apoptosis of melanocytic cells. -tissue_expression_up hsa-mir-301a Prostate Neoplasms 22719071 upregulated in prostate cancer stem/progenitor cell. -tissue_expression_up hsa-mir-301b Prostate Neoplasms 22719071 upregulated in prostate cancer stem/progenitor cell. -tissue_expression_up hsa-mir-452 Prostate Neoplasms 22719071 upregulated in prostate cancer stem/progenitor cell. -tissue_expression_up hsa-mir-137 Glioblastoma 22722712 "miR-181b, miR-153, miR-145, miR-137, and let-7d were significantly upregulated after treatment with both TMZ (temozolomide ) and OLE (Olea europaea leaf extract)." -tissue_expression_up hsa-mir-145 Glioblastoma 22722712 "miR-181b, miR-153, miR-145, miR-137, and let-7d were significantly upregulated after treatment with both TMZ (temozolomide ) and OLE (Olea europaea leaf extract)." -tissue_expression_up hsa-mir-153-1 Glioblastoma 22722712 "miR-181b, miR-153, miR-145, miR-137, and let-7d were significantly upregulated after treatment with both TMZ (temozolomide ) and OLE (Olea europaea leaf extract)." -tissue_expression_up hsa-mir-153-2 Glioblastoma 22722712 "miR-181b, miR-153, miR-145, miR-137, and let-7d were significantly upregulated after treatment with both TMZ (temozolomide ) and OLE (Olea europaea leaf extract)." -tissue_expression_up hsa-mir-181b-1 Glioblastoma 22722712 "miR-181b, miR-153, miR-145, miR-137, and let-7d were significantly upregulated after treatment with both TMZ (temozolomide ) and OLE (Olea europaea leaf extract)." -tissue_expression_up hsa-mir-181b-2 Glioblastoma 22722712 "miR-181b, miR-153, miR-145, miR-137, and let-7d were significantly upregulated after treatment with both TMZ (temozolomide ) and OLE (Olea europaea leaf extract)." -tissue_expression_up hsa-mir-1 Heart Failure 22735911 "Some miRNAs highly expressed in the heart, such as miR-1,miR-133 and miR-208, are strongly associated with the development of cardiac hypertrophy, while the exact role of miR-21 in the cardiovascular system remains controversial." -tissue_expression_up hsa-mir-133 Heart Failure 22735911 "Some miRNAs highly expressed in the heart, such as miR-1,miR-133 and miR-208, are strongly associated with the development of cardiac hypertrophy, while the exact role of miR-21 in the cardiovascular system remains controversial." -tissue_expression_up hsa-mir-208 Heart Failure 22735911 "Some miRNAs highly expressed in the heart, such as miR-1,miR-133 and miR-208, are strongly associated with the development of cardiac hypertrophy, while the exact role of miR-21 in the cardiovascular system remains controversial." -tissue_expression_up hsa-mir-21 Heart Failure 22735911 "Some miRNAs highly expressed in the heart, such as miR-1,miR-133 and miR-208, are strongly associated with the development of cardiac hypertrophy, while the exact role of miR-21 in the cardiovascular system remains controversial." -tissue_expression_up hsa-mir-21 Multiple Myeloma 22739167 "It is concluded that the expression levels of miR-21 in BMMNC of MM patients are significantly higher than in normal bone marrow, these data indicated that miR-21 may play an important role in the development of MM." -tissue_expression_up hsa-mir-10b Colorectal Carcinoma 22740910 "Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas." -tissue_expression_up hsa-mir-125b Colorectal Carcinoma 22740910 "Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas." -tissue_expression_up hsa-mir-126 Colorectal Carcinoma 22740910 "Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas." -tissue_expression_up hsa-mir-133a Colorectal Carcinoma 22740910 "Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas." -tissue_expression_up hsa-mir-133b Colorectal Carcinoma 22740910 "Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas." -tissue_expression_up hsa-mir-143 Colorectal Carcinoma 22740910 "Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas." -tissue_expression_up hsa-mir-145 Colorectal Carcinoma 22740910 "Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas." -tissue_expression_up hsa-mir-146a Colorectal Carcinoma 22740910 "Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas." -tissue_expression_up hsa-mir-199a Colorectal Carcinoma 22740910 "Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas." -tissue_expression_up hsa-mir-199b Colorectal Carcinoma 22740910 "Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas." -tissue_expression_up hsa-mir-22 Colorectal Carcinoma 22740910 "Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas." -tissue_expression_up hsa-mir-28 Colorectal Carcinoma 22740910 "Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas." -tissue_expression_up hsa-mir-576 Colorectal Carcinoma 22740910 "Overexpression of miR-145, miR-1, miR-146a, miR-576-5p, miR-126*, HS287, miR-28-5p, miR-143, miR-199b-5p, miR-199a-5p, miR-10b, miR-22, miR-133b, miR-145*, miR-199a, miR-133a, miR-125b and downregulation of miR-31 and HS170 were observed in brain-metastatic carcinomas." -tissue_expression_up hsa-mir-127 Thyroid Neoplasms 22747440 "MTC and CCH were both characterized by a significant overexpression of the whole set of miRNAs (the increase being 4.2-fold for miR-21, 6.7-fold for miR-127, 8.8-fold for miR-154, 6.6-fold for miR-224, 5.8-fold for miR-323, 6.1-fold for miR-370, 13-fold for miR-9*, 6.7-fold for miR-183, and 10.1 for miR-375, p<0.0001)." -tissue_expression_up hsa-mir-154 Thyroid Neoplasms 22747440 "MTC and CCH were both characterized by a significant overexpression of the whole set of miRNAs (the increase being 4.2-fold for miR-21, 6.7-fold for miR-127, 8.8-fold for miR-154, 6.6-fold for miR-224, 5.8-fold for miR-323, 6.1-fold for miR-370, 13-fold for miR-9*, 6.7-fold for miR-183, and 10.1 for miR-375, p<0.0001)." -tissue_expression_up hsa-mir-183 Thyroid Neoplasms 22747440 "MTC and CCH were both characterized by a significant overexpression of the whole set of miRNAs (the increase being 4.2-fold for miR-21, 6.7-fold for miR-127, 8.8-fold for miR-154, 6.6-fold for miR-224, 5.8-fold for miR-323, 6.1-fold for miR-370, 13-fold for miR-9*, 6.7-fold for miR-183, and 10.1 for miR-375, p<0.0001)." -tissue_expression_up hsa-mir-21 Thyroid Neoplasms 22747440 "MTC and CCH were both characterized by a significant overexpression of the whole set of miRNAs (the increase being 4.2-fold for miR-21, 6.7-fold for miR-127, 8.8-fold for miR-154, 6.6-fold for miR-224, 5.8-fold for miR-323, 6.1-fold for miR-370, 13-fold for miR-9*, 6.7-fold for miR-183, and 10.1 for miR-375, p<0.0001)." -tissue_expression_up hsa-mir-224 Thyroid Neoplasms 22747440 "MTC and CCH were both characterized by a significant overexpression of the whole set of miRNAs (the increase being 4.2-fold for miR-21, 6.7-fold for miR-127, 8.8-fold for miR-154, 6.6-fold for miR-224, 5.8-fold for miR-323, 6.1-fold for miR-370, 13-fold for miR-9*, 6.7-fold for miR-183, and 10.1 for miR-375, p<0.0001)." -tissue_expression_up hsa-mir-323 Thyroid Neoplasms 22747440 "MTC and CCH were both characterized by a significant overexpression of the whole set of miRNAs (the increase being 4.2-fold for miR-21, 6.7-fold for miR-127, 8.8-fold for miR-154, 6.6-fold for miR-224, 5.8-fold for miR-323, 6.1-fold for miR-370, 13-fold for miR-9*, 6.7-fold for miR-183, and 10.1 for miR-375, p<0.0001)." -tissue_expression_up hsa-mir-370 Thyroid Neoplasms 22747440 "MTC and CCH were both characterized by a significant overexpression of the whole set of miRNAs (the increase being 4.2-fold for miR-21, 6.7-fold for miR-127, 8.8-fold for miR-154, 6.6-fold for miR-224, 5.8-fold for miR-323, 6.1-fold for miR-370, 13-fold for miR-9*, 6.7-fold for miR-183, and 10.1 for miR-375, p<0.0001)." -tissue_expression_up hsa-mir-375 Thyroid Neoplasms 22747440 "MTC and CCH were both characterized by a significant overexpression of the whole set of miRNAs (the increase being 4.2-fold for miR-21, 6.7-fold for miR-127, 8.8-fold for miR-154, 6.6-fold for miR-224, 5.8-fold for miR-323, 6.1-fold for miR-370, 13-fold for miR-9*, 6.7-fold for miR-183, and 10.1 for miR-375, p<0.0001)." -tissue_expression_up hsa-mir-9 Thyroid Neoplasms 22747440 "MTC and CCH were both characterized by a significant overexpression of the whole set of miRNAs (the increase being 4.2-fold for miR-21, 6.7-fold for miR-127, 8.8-fold for miR-154, 6.6-fold for miR-224, 5.8-fold for miR-323, 6.1-fold for miR-370, 13-fold for miR-9*, 6.7-fold for miR-183, and 10.1 for miR-375, p<0.0001)." -tissue_expression_up hsa-mir-125b-2 Myotonic Muscular Dystrophy 22768114 miR-125b-5p: decreased levels compared to controls -tissue_expression_up hsa-mir-146b Myotonic Muscular Dystrophy 22768114 higher levels compared to controls -tissue_expression_up hsa-mir-208a Myotonic Muscular Dystrophy 22768114 miR-146b-5p: higher levels compared to controls -tissue_expression_up hsa-mir-221 Myotonic Muscular Dystrophy 22768114 higher levels compared to controls -tissue_expression_up hsa-mir-34a Myotonic Muscular Dystrophy 22768114 miR-34a-5p: higher levels compared to controls -tissue_expression_up hsa-mir-34b Myotonic Muscular Dystrophy 22768114 miR-34b-3p: higher levels compared to controls -tissue_expression_up hsa-mir-34c Myotonic Muscular Dystrophy 22768114 miR-34c-5p: higher levels compared to controls -tissue_expression_up hsa-mir-381 Myotonic Muscular Dystrophy 22768114 higher levels compared to controls -tissue_expression_up hsa-mir-92a-1 Colorectal Carcinoma 22772712 Overexpression of miR-92a correlates with tumor metastasis and poor prognosis in patients with colorectal cancer. -tissue_expression_up hsa-mir-668 Interstitial Lung Disease 22782705 upregulated -tissue_expression_up hsa-mir-92b Interstitial Lung Disease 22782705 upregulated -tissue_expression_up hsa-mir-15a Ischemia-Reperfusion Injury 22783320 MicroRNA-15a/b are up-regulated in response to myocardial ischemia/reperfusion injury. -tissue_expression_up hsa-mir-15a Myocardial Ischemic-Reperfusion Injury 22783320 MicroRNA-15a/b are up-regulated in response to myocardial ischemia/reperfusion injury. -tissue_expression_up hsa-mir-15b Ischemia-Reperfusion Injury 22783320 MicroRNA-15a/b are up-regulated in response to myocardial ischemia/reperfusion injury. -tissue_expression_up hsa-mir-15b Myocardial Ischemic-Reperfusion Injury 22783320 MicroRNA-15a/b are up-regulated in response to myocardial ischemia/reperfusion injury. -tissue_expression_up hsa-mir-182 Glioma 22788545 "The concentration of miRNA-182 in glioma patients was found to be 3.1 times as high as that in healthy persons, a conclusion in excellent agreement with a separate qPCR measurement of the expression level." -tissue_expression_up hsa-mir-21 Head And Neck Neoplasms 22811001 "The expression level of miR-21 was significantly up-regulated in plasma samples obtained from HNSCC patients (p<0.01) than those from healthy subjects, which were in consistent with our finding in HNSCC tissues." -tissue_expression_up hsa-mir-142 Eosinophilic Esophagitis 22815788 "Compared to the post-glucocorticoid treated esophageal mucosa,MiR-214, miR-146b-5b, 146a, 145, 142-3p and 21 were upregulated." -tissue_expression_up hsa-mir-145 Eosinophilic Esophagitis 22815788 "Compared to the post-glucocorticoid treated esophageal mucosa,MiR-214, miR-146b-5b, 146a, 145, 142-3p and 21 were upregulated." -tissue_expression_up hsa-mir-146a Eosinophilic Esophagitis 22815788 "Compared to the post-glucocorticoid treated esophageal mucosa,MiR-214, miR-146b-5b, 146a, 145, 142-3p and 21 were upregulated." -tissue_expression_up hsa-mir-146b Eosinophilic Esophagitis 22815788 "Compared to the post-glucocorticoid treated esophageal mucosa,MiR-214, miR-146b-5b, 146a, 145, 142-3p and 21 were upregulated." -tissue_expression_up hsa-mir-21 Eosinophilic Esophagitis 22815788 "Compared to the post-glucocorticoid treated esophageal mucosa,MiR-214, miR-146b-5b, 146a, 145, 142-3p and 21 were upregulated." -tissue_expression_up hsa-mir-106b Glioma 22825541 Upregulation of miR-20a and miR-106b is involved in the acquisition of malignancy of pediatric brainstem gliomas. -tissue_expression_up hsa-mir-20a Glioma 22825541 Upregulation of miR-20a and miR-106b is involved in the acquisition of malignancy of pediatric brainstem gliomas. -tissue_expression_up hsa-mir-146a Nasopharyngeal Neoplasms 22843060 Expression of miRNA-146a in nasopharyngeal carcinoma is upregulated by Epstein-Barr virus latent membrane protein 1. -tissue_expression_up hsa-mir-214 Liver Cirrhosis 22849305 miR-214-5p was upregulated in human and mouse livers in a fibrosis progression-dependent manner. -tissue_expression_up hsa-mir-155 Pancreatic Neoplasms 22850622 "miR-21, miR-155, miR-210, miR-221, and miR-222, were overexpressed in diseased tissues than in the control samples, whereas miR-31, miR-122, miR-145, and miR-146a were underexpressed." -tissue_expression_up hsa-mir-21 Pancreatic Neoplasms 22850622 "miR-21, miR-155, miR-210, miR-221, and miR-222, were overexpressed in diseased tissues than in the control samples, whereas miR-31, miR-122, miR-145, and miR-146a were underexpressed." -tissue_expression_up hsa-mir-210 Pancreatic Neoplasms 22850622 "miR-21, miR-155, miR-210, miR-221, and miR-222, were overexpressed in diseased tissues than in the control samples, whereas miR-31, miR-122, miR-145, and miR-146a were underexpressed." -tissue_expression_up hsa-mir-222 Pancreatic Neoplasms 22850622 "miR-21, miR-155, miR-210, miR-221, and miR-222, were overexpressed in diseased tissues than in the control samples, whereas miR-31, miR-122, miR-145, and miR-146a were underexpressed." -tissue_expression_up hsa-mir-208b Heart Failure 22859947 "Increasing doses of doxorubicin, but not etoposide (a Topoisomerase II inhibitor devoid of cardiovascular toxicity), specifically induced the up-regulation of miR-208b, miR-216b, miR-215, miR-34c and miR-367 in rat hearts. " -tissue_expression_up hsa-mir-215 Heart Failure 22859947 "Increasing doses of doxorubicin, but not etoposide (a Topoisomerase II inhibitor devoid of cardiovascular toxicity), specifically induced the up-regulation of miR-208b, miR-216b, miR-215, miR-34c and miR-367 in rat hearts. " -tissue_expression_up hsa-mir-216b Heart Failure 22859947 "Increasing doses of doxorubicin, but not etoposide (a Topoisomerase II inhibitor devoid of cardiovascular toxicity), specifically induced the up-regulation of miR-208b, miR-216b, miR-215, miR-34c and miR-367 in rat hearts. " -tissue_expression_up hsa-mir-34c Heart Failure 22859947 "Increasing doses of doxorubicin, but not etoposide (a Topoisomerase II inhibitor devoid of cardiovascular toxicity), specifically induced the up-regulation of miR-208b, miR-216b, miR-215, miR-34c and miR-367 in rat hearts. " -tissue_expression_up hsa-mir-367 Heart Failure 22859947 "Increasing doses of doxorubicin, but not etoposide (a Topoisomerase II inhibitor devoid of cardiovascular toxicity), specifically induced the up-regulation of miR-208b, miR-216b, miR-215, miR-34c and miR-367 in rat hearts. " -tissue_expression_up hsa-mir-141 Urinary Bladder Cancer 22886973 "hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated." -tissue_expression_up hsa-mir-200a Urinary Bladder Cancer 22886973 "hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated." -tissue_expression_up hsa-mir-200c Urinary Bladder Cancer 22886973 "hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated." -tissue_expression_up hsa-mir-29c Urinary Bladder Cancer 22886973 "hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated." -tissue_expression_up hsa-mir-378a Urinary Bladder Cancer 22886973 "hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated." -tissue_expression_up hsa-mir-378b Urinary Bladder Cancer 22886973 "hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated." -tissue_expression_up hsa-mir-378c Urinary Bladder Cancer 22886973 "hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated." -tissue_expression_up hsa-mir-378d-1 Urinary Bladder Cancer 22886973 "hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated." -tissue_expression_up hsa-mir-378d-2 Urinary Bladder Cancer 22886973 "hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated." -tissue_expression_up hsa-mir-378e Urinary Bladder Cancer 22886973 "hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated." -tissue_expression_up hsa-mir-378f Urinary Bladder Cancer 22886973 "hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated." -tissue_expression_up hsa-mir-378g Urinary Bladder Cancer 22886973 "hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated." -tissue_expression_up hsa-mir-378h Urinary Bladder Cancer 22886973 "hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated." -tissue_expression_up hsa-mir-378i Urinary Bladder Cancer 22886973 "hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated." -tissue_expression_up hsa-mir-429 Urinary Bladder Cancer 22886973 "hsa-mir-29c, hsa-miR-200a, hsa-miR-378, hsa-miR-429, hsa-miR-200c and hsa-miR-141 were up-regulated, while hsa-miR-451 was down-regulated." -tissue_expression_up hsa-mir-221 Asthma 22895815 Upregulation of miRNA-221 and miRNA-485-3p in pediatric asthma. -tissue_expression_up hsa-mir-485 Asthma 22895815 Upregulation of miRNA-221 and miRNA-485-3p in pediatric asthma. -tissue_expression_up hsa-mir-1225 Melanoma 22898827 "we assayed the MITF-KD miRNA profiles using a miRNA microarray and found that hsa-miR-1225-3p, hsa-miR-634, hsa-miR-197, hsa-miR-766, hsa-miR-574-5p and hsa-miR-328 were upregulated, and hsa-miR-720 and hsa-miR-1308 were downregulated in MITF knocked down melanocytes." -tissue_expression_up hsa-mir-197 Melanoma 22898827 "we assayed the MITF-KD miRNA profiles using a miRNA microarray and found that hsa-miR-1225-3p, hsa-miR-634, hsa-miR-197, hsa-miR-766, hsa-miR-574-5p and hsa-miR-328 were upregulated, and hsa-miR-720 and hsa-miR-1308 were downregulated in MITF knocked down melanocytes." -tissue_expression_up hsa-mir-328 Melanoma 22898827 "we assayed the MITF-KD miRNA profiles using a miRNA microarray and found that hsa-miR-1225-3p, hsa-miR-634, hsa-miR-197, hsa-miR-766, hsa-miR-574-5p and hsa-miR-328 were upregulated, and hsa-miR-720 and hsa-miR-1308 were downregulated in MITF knocked down melanocytes." -tissue_expression_up hsa-mir-574 Melanoma 22898827 "we assayed the MITF-KD miRNA profiles using a miRNA microarray and found that hsa-miR-1225-3p, hsa-miR-634, hsa-miR-197, hsa-miR-766, hsa-miR-574-5p and hsa-miR-328 were upregulated, and hsa-miR-720 and hsa-miR-1308 were downregulated in MITF knocked down melanocytes." -tissue_expression_up hsa-mir-634 Melanoma 22898827 "we assayed the MITF-KD miRNA profiles using a miRNA microarray and found that hsa-miR-1225-3p, hsa-miR-634, hsa-miR-197, hsa-miR-766, hsa-miR-574-5p and hsa-miR-328 were upregulated, and hsa-miR-720 and hsa-miR-1308 were downregulated in MITF knocked down melanocytes." -tissue_expression_up hsa-mir-766 Melanoma 22898827 "we assayed the MITF-KD miRNA profiles using a miRNA microarray and found that hsa-miR-1225-3p, hsa-miR-634, hsa-miR-197, hsa-miR-766, hsa-miR-574-5p and hsa-miR-328 were upregulated, and hsa-miR-720 and hsa-miR-1308 were downregulated in MITF knocked down melanocytes." -tissue_expression_up hsa-mir-128a Colon Neoplasms 22898888 "in colonic fibroblasts p38 was only moderately activated, p53 as well as p16 expressions were upregulated in the presence of increased expression of miR-34a, miR-128a and miR-449a." -tissue_expression_up hsa-mir-34a Colon Neoplasms 22898888 "in colonic fibroblasts p38 was only moderately activated, p53 as well as p16 expressions were upregulated in the presence of increased expression of miR-34a, miR-128a and miR-449a." -tissue_expression_up hsa-mir-449a Colon Neoplasms 22898888 "in colonic fibroblasts p38 was only moderately activated, p53 as well as p16 expressions were upregulated in the presence of increased expression of miR-34a, miR-128a and miR-449a." -tissue_expression_up hsa-mir-147a "Tuberculosis, Pulmonary" 22900099 Overexpression -tissue_expression_up hsa-mir-147b "Tuberculosis, Pulmonary" 22900099 Overexpression -tissue_expression_up hsa-mir-3179-1 "Tuberculosis, Pulmonary" 22900099 Overexpression -tissue_expression_up hsa-mir-3179-2 "Tuberculosis, Pulmonary" 22900099 Overexpression -tissue_expression_up hsa-mir-3179-3 "Tuberculosis, Pulmonary" 22900099 Overexpression -tissue_expression_up hsa-mir-181b-1 Gastric Neoplasms 22901205 The upregulation of miR-181b may play an important role in the progress of gastric cancer and miR-181b maybe a potential molecular target for anticancer therapeutics of gastric cancer. -tissue_expression_up hsa-mir-181b-2 Gastric Neoplasms 22901205 The upregulation of miR-181b may play an important role in the progress of gastric cancer and miR-181b maybe a potential molecular target for anticancer therapeutics of gastric cancer. -tissue_expression_up hsa-mir-200b Endometrial Neoplasms 22904162 miR-200b and -210 were significantly up-regulated in the cancerous endometrium. -tissue_expression_up hsa-mir-210 Endometrial Neoplasms 22904162 miR-200b and -210 were significantly up-regulated in the cancerous endometrium. -tissue_expression_up hsa-mir-10b Pancreatic Neoplasms 22910491 MicroRNA-10b is overexpressed in pancreatic cancer. -tissue_expression_up hsa-mir-155 "Carcinoma, Neuroendocrine" 22924844 The expression levels of miR-21 and miR-155 were significantly higher in high-grade NE carcinomas (LCNECs and SCLCs) than in carcinoid tumors (TCs and ACs) (each P < 0.001). The expression level of miR-21 in carcinoid tumors with lymph node metastasis was significantly higher than in carcinoid tumors without lymph node metastasis (P= 0.010). -tissue_expression_up hsa-mir-21 "Carcinoma, Neuroendocrine" 22924844 The expression levels of miR-21 and miR-155 were significantly higher in high-grade NE carcinomas (LCNECs and SCLCs) than in carcinoid tumors (TCs and ACs) (each P < 0.001). The expression level of miR-21 in carcinoid tumors with lymph node metastasis was significantly higher than in carcinoid tumors without lymph node metastasis (P= 0.010). -tissue_expression_up hsa-mir-451a Pancreatic Neoplasms 22929886 "The expression of let-7c, let-7f, and miR-200c were significantly reduced in most patients whereas the expression of miR-486-5p and miR-451 were significantly elevated in all pancreas cancer patients." -tissue_expression_up hsa-mir-451b Pancreatic Neoplasms 22929886 "The expression of let-7c, let-7f, and miR-200c were significantly reduced in most patients whereas the expression of miR-486-5p and miR-451 were significantly elevated in all pancreas cancer patients." -tissue_expression_up hsa-mir-486 Pancreatic Neoplasms 22929886 "The expression of let-7c, let-7f, and miR-200c were significantly reduced in most patients whereas the expression of miR-486-5p and miR-451 were significantly elevated in all pancreas cancer patients." -tissue_expression_up hsa-mir-135b Esophageal Neoplasms 22939244 Patients with high levels of miR-135b or miR-145 in the posttreatment biopsy specimens had significantly shorter median disease-free survival (DFS) than did those with low levels. -tissue_expression_up hsa-mir-16-1 Acute Lung Injury 22940131 "miR-16 upregulates ENaC, a major sodium channel involved in resolution of pulmonary edema in acute lung injury." -tissue_expression_up hsa-mir-16-2 Acute Lung Injury 22940131 "miR-16 upregulates ENaC, a major sodium channel involved in resolution of pulmonary edema in acute lung injury." -tissue_expression_up hsa-mir-142 Atrial Fibrillation 22944230 "MiR-155, miR-142-3p, miR-19b, miR-223, miR-146b-5p, miR-486-5p, miR-301b, miR-193b, miR-519b were found to be up-regulated by > 2 folds whereas miR-193a-5p was down-regulated in left atrial appendage (LAA) in patients with atrial fibrillation." -tissue_expression_up hsa-mir-146b Atrial Fibrillation 22944230 "MiR-155, miR-142-3p, miR-19b, miR-223, miR-146b-5p, miR-486-5p, miR-301b, miR-193b, miR-519b were found to be up-regulated by > 2 folds whereas miR-193a-5p was down-regulated in left atrial appendage (LAA) in patients with atrial fibrillation." -tissue_expression_up hsa-mir-155 Atrial Fibrillation 22944230 "MiR-155, miR-142-3p, miR-19b, miR-223, miR-146b-5p, miR-486-5p, miR-301b, miR-193b, miR-519b were found to be up-regulated by > 2 folds whereas miR-193a-5p was down-regulated in left atrial appendage (LAA) in patients with atrial fibrillation." -tissue_expression_up hsa-mir-193b Atrial Fibrillation 22944230 "MiR-155, miR-142-3p, miR-19b, miR-223, miR-146b-5p, miR-486-5p, miR-301b, miR-193b, miR-519b were found to be up-regulated by > 2 folds whereas miR-193a-5p was down-regulated in left atrial appendage (LAA) in patients with atrial fibrillation." -tissue_expression_up hsa-mir-19a Atrial Fibrillation 22944230 "MiR-155, miR-142-3p, miR-19b, miR-223, miR-146b-5p, miR-486-5p, miR-301b, miR-193b, miR-519b were found to be up-regulated by > 2 folds whereas miR-193a-5p was down-regulated in left atrial appendage (LAA) in patients with atrial fibrillation." -tissue_expression_up hsa-mir-19b-1 Atrial Fibrillation 22944230 "MiR-155, miR-142-3p, miR-19b, miR-223, miR-146b-5p, miR-486-5p, miR-301b, miR-193b, miR-519b were found to be up-regulated by > 2 folds whereas miR-193a-5p was down-regulated in left atrial appendage (LAA) in patients with atrial fibrillation." -tissue_expression_up hsa-mir-19b-2 Atrial Fibrillation 22944230 "MiR-155, miR-142-3p, miR-19b, miR-223, miR-146b-5p, miR-486-5p, miR-301b, miR-193b, miR-519b were found to be up-regulated by > 2 folds whereas miR-193a-5p was down-regulated in left atrial appendage (LAA) in patients with atrial fibrillation." -tissue_expression_up hsa-mir-223 Atrial Fibrillation 22944230 "MiR-155, miR-142-3p, miR-19b, miR-223, miR-146b-5p, miR-486-5p, miR-301b, miR-193b, miR-519b were found to be up-regulated by > 2 folds whereas miR-193a-5p was down-regulated in left atrial appendage (LAA) in patients with atrial fibrillation." -tissue_expression_up hsa-mir-486 Atrial Fibrillation 22944230 "MiR-155, miR-142-3p, miR-19b, miR-223, miR-146b-5p, miR-486-5p, miR-301b, miR-193b, miR-519b were found to be up-regulated by > 2 folds whereas miR-193a-5p was down-regulated in left atrial appendage (LAA) in patients with atrial fibrillation." -tissue_expression_up hsa-mir-519b Atrial Fibrillation 22944230 "MiR-155, miR-142-3p, miR-19b, miR-223, miR-146b-5p, miR-486-5p, miR-301b, miR-193b, miR-519b were found to be up-regulated by > 2 folds whereas miR-193a-5p was down-regulated in left atrial appendage (LAA) in patients with atrial fibrillation." -tissue_expression_up hsa-mir-221 Breast Neoplasms 22964023 "We identified 11 dysregulated miRNAs in CAFs: three were up-regulated (miR-221-5p, miR-31-3p, miR-221-3p), while eight were down-regulated (miR-205, miR-200b, miR-200c, miR-141, miR-101,miR-342-3p, let-7g, miR-26b)" -tissue_expression_up hsa-mir-31 Breast Neoplasms 22964023 "We identified 11 dysregulated miRNAs in CAFs: three were up-regulated (miR-221-5p, miR-31-3p, miR-221-3p), while eight were down-regulated (miR-205, miR-200b, miR-200c, miR-141, miR-101,miR-342-3p, let-7g, miR-26b)" -tissue_expression_up hsa-mir-424 Tuberculosis 22964481 "we observed that miR-146a expression is also down-regulated in tuberculosis patients, both in PBMCs and PFMCs while miR-424 levels are elevated only in the peripheral compartments." -tissue_expression_up hsa-let-7b Prion Diseases 22965126 "we show that exosomes released by prion-infected neuronal cells have increased let-7b, let-7i, miR-128a, miR-21, miR-222, miR-29b,miR-342-3p and miR-424 levels with decreased miR-146 a levels compared to non-infected exosomes." -tissue_expression_up hsa-let-7i Prion Diseases 22965126 "we show that exosomes released by prion-infected neuronal cells have increased let-7b, let-7i, miR-128a, miR-21, miR-222, miR-29b,miR-342-3p and miR-424 levels with decreased miR-146 a levels compared to non-infected exosomes." -tissue_expression_up hsa-mir-128a Prion Diseases 22965126 "we show that exosomes released by prion-infected neuronal cells have increased let-7b, let-7i, miR-128a, miR-21, miR-222, miR-29b,miR-342-3p and miR-424 levels with decreased miR-146 a levels compared to non-infected exosomes." -tissue_expression_up hsa-mir-21 Prion Diseases 22965126 "we show that exosomes released by prion-infected neuronal cells have increased let-7b, let-7i, miR-128a, miR-21, miR-222, miR-29b,miR-342-3p and miR-424 levels with decreased miR-146 a levels compared to non-infected exosomes." -tissue_expression_up hsa-mir-222 Prion Diseases 22965126 "we show that exosomes released by prion-infected neuronal cells have increased let-7b, let-7i, miR-128a, miR-21, miR-222, miR-29b,miR-342-3p and miR-424 levels with decreased miR-146 a levels compared to non-infected exosomes." -tissue_expression_up hsa-mir-29b Prion Diseases 22965126 "we show that exosomes released by prion-infected neuronal cells have increased let-7b, let-7i, miR-128a, miR-21, miR-222, miR-29b,miR-342-3p and miR-424 levels with decreased miR-146 a levels compared to non-infected exosomes." -tissue_expression_up hsa-mir-342 Prion Diseases 22965126 "we show that exosomes released by prion-infected neuronal cells have increased let-7b, let-7i, miR-128a, miR-21, miR-222, miR-29b,miR-342-3p and miR-424 levels with decreased miR-146 a levels compared to non-infected exosomes." -tissue_expression_up hsa-mir-424 Prion Diseases 22965126 "we show that exosomes released by prion-infected neuronal cells have increased let-7b, let-7i, miR-128a, miR-21, miR-222, miR-29b,miR-342-3p and miR-424 levels with decreased miR-146 a levels compared to non-infected exosomes." -tissue_expression_up hsa-mir-107 "Leukemia, Promyelocytic, Acute" 22967415 "The expression level of miR-15b, miR-16, miR-107, miR-223 and miR-342 in APL CR group were significantly upregulated compared with that of newly diagnosed APL groups (P < 0.05), while the expression level of miR-181a was significantly downregulated (P < 0.05)." -tissue_expression_up hsa-mir-15b "Leukemia, Promyelocytic, Acute" 22967415 "The expression level of miR-15b, miR-16, miR-107, miR-223 and miR-342 in APL CR group were significantly upregulated compared with that of newly diagnosed APL groups (P < 0.05), while the expression level of miR-181a was significantly downregulated (P < 0.05)." -tissue_expression_up hsa-mir-16 "Leukemia, Promyelocytic, Acute" 22967415 "The expression level of miR-15b, miR-16, miR-107, miR-223 and miR-342 in APL CR group were significantly upregulated compared with that of newly diagnosed APL groups (P < 0.05), while the expression level of miR-181a was significantly downregulated (P < 0.05)." -tissue_expression_up hsa-mir-223 "Leukemia, Promyelocytic, Acute" 22967415 "The expression level of miR-15b, miR-16, miR-107, miR-223 and miR-342 in APL CR group were significantly upregulated compared with that of newly diagnosed APL groups (P < 0.05), while the expression level of miR-181a was significantly downregulated (P < 0.05)." -tissue_expression_up hsa-mir-342 "Leukemia, Promyelocytic, Acute" 22967415 "The expression level of miR-15b, miR-16, miR-107, miR-223 and miR-342 in APL CR group were significantly upregulated compared with that of newly diagnosed APL groups (P < 0.05), while the expression level of miR-181a was significantly downregulated (P < 0.05)." -tissue_expression_up hsa-mir-103 Gastrointestinal Neoplasms 22996433 "The high expression of miR-20a, miR-25, miR-93, miR-103, miR-106a, miR-106b, miR-130 was associated with lymph node metastasis" -tissue_expression_up hsa-mir-106a Gastrointestinal Neoplasms 22996433 "The high expression of miR-20a, miR-25, miR-93, miR-103, miR-106a, miR-106b, miR-130 was associated with lymph node metastasis" -tissue_expression_up hsa-mir-106b Gastrointestinal Neoplasms 22996433 "The high expression of miR-20a, miR-25, miR-93, miR-103, miR-106a, miR-106b, miR-130 was associated with lymph node metastasis" -tissue_expression_up hsa-mir-130 Gastrointestinal Neoplasms 22996433 "The high expression of miR-20a, miR-25, miR-93, miR-103, miR-106a, miR-106b, miR-130 was associated with lymph node metastasis" -tissue_expression_up hsa-mir-20a Gastrointestinal Neoplasms 22996433 "The high expression of miR-20a, miR-25, miR-93, miR-103, miR-106a, miR-106b, miR-130 was associated with lymph node metastasis" -tissue_expression_up hsa-mir-221 Gastrointestinal Neoplasms 22996433 "The high expression of miR-222 and miR-221 showed correlation with shorter metastasis-free survival (P?=?0.039 and 0.033,respectively), and miR-222 high expression was related to reduced overall survival (P?=?0.012)." -tissue_expression_up hsa-mir-222 Gastrointestinal Neoplasms 22996433 "The high expression of miR-222 and miR-221 showed correlation with shorter metastasis-free survival (P?=?0.039 and 0.033,respectively), and miR-222 high expression was related to reduced overall survival (P?=?0.012)." -tissue_expression_up hsa-mir-25 Gastrointestinal Neoplasms 22996433 "The high expression of miR-20a, miR-25, miR-93, miR-103, miR-106a, miR-106b, miR-130 was associated with lymph node metastasis" -tissue_expression_up hsa-mir-93 Gastrointestinal Neoplasms 22996433 "The high expression of miR-20a, miR-25, miR-93, miR-103, miR-106a, miR-106b, miR-130 was associated with lymph node metastasis" -tissue_expression_up hsa-mir-21 Cervical Neoplasms 22997891 "The high expression of miR-21 in cervical cancer and Hela cell indicate that it may play a possible role of oncogenes, while miR-143 and miR-373 with low expression may play the role of tumor suppressor genes." -tissue_expression_up hsa-mir-10a Prostate Neoplasms 22999546 "miR-100 and miR-10a showed under expression and over expression, respectively, in low grade pTa tumors." -tissue_expression_up hsa-mir-135b "Squamous Cell Carcinoma, Skin or Unspecific" 23026055 "Non-stringent filtering with a non-adjusted p ¡Ü 0.01 revealed three up-regulated (hsa-miR-135b, hsa-miR-424 and hsa-miR-766) and six down-regulated (hsa-miR-30a*, hsa-miR-378, hsa-miR-145, hsa-miR-140-3p, hsa-miR-30a and hsa-miR-26a) miRNAs in cSCC" -tissue_expression_up hsa-mir-424 "Squamous Cell Carcinoma, Skin or Unspecific" 23026055 "Non-stringent filtering with a non-adjusted p ¡Ü 0.01 revealed three up-regulated (hsa-miR-135b, hsa-miR-424 and hsa-miR-766) and six down-regulated (hsa-miR-30a*, hsa-miR-378, hsa-miR-145, hsa-miR-140-3p, hsa-miR-30a and hsa-miR-26a) miRNAs in cSCC" -tissue_expression_up hsa-mir-766 "Squamous Cell Carcinoma, Skin or Unspecific" 23026055 "Non-stringent filtering with a non-adjusted p ¡Ü 0.01 revealed three up-regulated (hsa-miR-135b, hsa-miR-424 and hsa-miR-766) and six down-regulated (hsa-miR-30a*, hsa-miR-378, hsa-miR-145, hsa-miR-140-3p, hsa-miR-30a and hsa-miR-26a) miRNAs in cSCC" -tissue_expression_up hsa-mir-372 Seminoma 23064661 "Hsa-mir-372 was upregulated around 1,270-fold (95?% confidence interval (CI) 525.2-3,064.8; sp?=?8.1e-5 by Mann-Whitney U test)" -tissue_expression_up hsa-mir-217 "Carcinoma, Hepatocellular" 23082062 "Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. " -tissue_expression_up hsa-mir-512 "Carcinoma, Hepatocellular" 23082062 "Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. " -tissue_expression_up hsa-mir-517c "Carcinoma, Hepatocellular" 23082062 "Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. " -tissue_expression_up hsa-mir-518a "Carcinoma, Hepatocellular" 23082062 "Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. " -tissue_expression_up hsa-mir-518b "Carcinoma, Hepatocellular" 23082062 "Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. " -tissue_expression_up hsa-mir-518e "Carcinoma, Hepatocellular" 23082062 "Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. " -tissue_expression_up hsa-mir-519a "Carcinoma, Hepatocellular" 23082062 "Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. " -tissue_expression_up hsa-mir-520g "Carcinoma, Hepatocellular" 23082062 "Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. " -tissue_expression_up hsa-mir-522 "Carcinoma, Hepatocellular" 23082062 "Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. " -tissue_expression_up hsa-mir-525 "Carcinoma, Hepatocellular" 23082062 "Ten up-regulated miRNAs (miR-217, miR-518b, miR-517c, miR-520g, miR-519a, miR-522, miR-518e, miR-525-3p, miR-512-3p, and miR-518a-3p) and 11 down-regulated miRNAs (miR-138, miR-214, miR-214#, miR-199a-5p, miR-433, miR-511, miR-592, miR-483-3p, miR-483-5p, miR-708 and miR-1275) were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues. " -tissue_expression_up hsa-mir-106 Esophageal Neoplasms 23092349 "A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. " -tissue_expression_up hsa-mir-106b Esophageal Neoplasms 23092349 "A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. " -tissue_expression_up hsa-mir-10b Esophageal Neoplasms 23092349 "A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. " -tissue_expression_up hsa-mir-151 Esophageal Neoplasms 23092349 "A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. " -tissue_expression_up hsa-mir-192 Esophageal Neoplasms 23092349 "A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. " -tissue_expression_up hsa-mir-194 Esophageal Neoplasms 23092349 "A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. " -tissue_expression_up hsa-mir-21 Esophageal Neoplasms 23092349 "A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. " -tissue_expression_up hsa-mir-25 Esophageal Neoplasms 23092349 "A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. " -tissue_expression_up hsa-mir-93 Esophageal Neoplasms 23092349 "A number of consistently dysregulated miRNAs have been identified in EAC and/or ESCC, including upregulation of miR-21, miR-192, miR-194, miR-106-25 polycistron (miR-25, miR-93, and miR-106b), miR-10b, miR-151, and miR-93, and downregulation of miR-375, miR-203, miR-205, miR-145, miR- 27b,miR-100, miR-125b, let-7c, etc. " -tissue_expression_up hsa-mir-155 "Carcinoma, Lung, Non-Small-Cell" 23099007 High expression of miR-21 and miR-155 predicts recurrence and unfavourable survival in non-small cell lung cancer. -tissue_expression_up hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 23099007 High expression of miR-21 and miR-155 predicts recurrence and unfavourable survival in non-small cell lung cancer. -tissue_expression_up hsa-mir-1260 Melanoma 23111773 "In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated." -tissue_expression_up hsa-mir-1274a Melanoma 23111773 "In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated." -tissue_expression_up hsa-mir-1274b Melanoma 23111773 "In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated." -tissue_expression_up hsa-mir-130b Melanoma 23111773 "In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated." -tissue_expression_up hsa-mir-146b Melanoma 23111773 "In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated." -tissue_expression_up hsa-mir-22 Melanoma 23111773 "In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated." -tissue_expression_up hsa-mir-223 Melanoma 23111773 "In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated." -tissue_expression_up hsa-mir-301a Melanoma 23111773 "In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated." -tissue_expression_up hsa-mir-3663 Melanoma 23111773 "In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated." -tissue_expression_up hsa-mir-4281 Melanoma 23111773 "In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated." -tissue_expression_up hsa-mir-4286 Melanoma 23111773 "In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated." -tissue_expression_up hsa-mir-484 Melanoma 23111773 "In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated." -tissue_expression_up hsa-mir-663 Melanoma 23111773 "In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated." -tissue_expression_up hsa-mir-720 Melanoma 23111773 "In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p,hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260,hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated." -tissue_expression_up hsa-mir-125b-1 Myocardial Ischemic-Reperfusion Injury 23123599 SR-A deficiency reduces myocardial ischemia/reperfusion injury; involvement of increased microRNA-125b expression in macrophages -tissue_expression_up hsa-mir-125b-2 Myocardial Ischemic-Reperfusion Injury 23123599 SR-A deficiency reduces myocardial ischemia/reperfusion injury; involvement of increased microRNA-125b expression in macrophages -tissue_expression_up hsa-mir-138 Bladder Neoplasms 23169479 "three miRNAs were upregulated (miR-200b, miR-182 and miR-138) and the other 10 miRNAs were downregulated (miR-1, miR-133a, miR-133b, miR-145, miR-143, miR-204, miR-921, miR-1281, miR-199a and miR-199b)" -tissue_expression_up hsa-mir-146b Bladder Neoplasms 23169479 "Except for two miRNAs, miR-146b and miR-9, which were specifically upregulated in MIBC, the majority of miRNAs (n = 13) were deregulated in the same way in the two types of bladder tumors" -tissue_expression_up hsa-mir-182 Bladder Neoplasms 23169479 "three miRNAs were upregulated (miR-200b, miR-182 and miR-138) and the other 10 miRNAs were downregulated (miR-1, miR-133a, miR-133b, miR-145, miR-143, miR-204, miR-921, miR-1281, miR-199a and miR-199b)" -tissue_expression_up hsa-mir-200b Bladder Neoplasms 23169479 "three miRNAs were upregulated (miR-200b, miR-182 and miR-138) and the other 10 miRNAs were downregulated (miR-1, miR-133a, miR-133b, miR-145, miR-143, miR-204, miR-921, miR-1281, miR-199a and miR-199b)" -tissue_expression_up hsa-mir-9 Bladder Neoplasms 23169479 "Except for two miRNAs, miR-146b and miR-9, which were specifically upregulated in MIBC, the majority of miRNAs (n = 13) were deregulated in the same way in the two types of bladder tumors" -tissue_expression_up hsa-mir-155 Ovarian Neoplasms 23171795 "We found that in ovarian CAFs, miR-31 and miR-214 were downregulated, whereas miR-155 was upregulated when compared with normal or tumor-adjacent fibroblasts." -tissue_expression_up hsa-mir-200c Breast Neoplasms 23185507 miR-200c targets a NF-kB up-regulated TrkB/NTF3 autocrine signaling loop to enhance anoikis sensitivity in triple negative breast cancer -tissue_expression_up hsa-mir-205 "Carcinoma, Lung, Non-Small-Cell" 23207443 SQCC was distinguished from normal tissue and ADC by high-level miR-205 expression and decreased miR-26b. -tissue_expression_up hsa-mir-122 Hepatitis B Virus Infection 23221562 HBV mRNAs-mediated miR-122 inhibition up-regulates PTTG1-binding protein which promotes HCC tumor growth and cell invasion -tissue_expression_up hsa-mir-17 Glioma 23226946 Increased Expression of microRNA-17 Predicts Poor Prognosis in Human Glioma -tissue_expression_up hsa-mir-18a Colon Neoplasms 23229340 MicroRNA-18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells -tissue_expression_up hsa-mir-155 Ovarian Neoplasms 23230184 They found that decreased miR-31 and miR-214 and increased miR-155 expression can reprogram normal fibroblasts into tumor-promoting cancer-associated fibroblasts. -tissue_expression_up hsa-mir-181a-2 Breast Neoplasms 23241956 TGF-beta upregulates miR-181a expression to promote breast cancer metastasis -tissue_expression_up hsa-mir-182 Ovarian Neoplasms 23262295 The upregulation of signal transducer and activator of transcription 5-dependent microRNA-182 and microRNA-96 promotes ovarian cancer cell proliferation by targeting forkhead box O3 upon leptin stimulation -tissue_expression_up hsa-mir-96 Ovarian Neoplasms 23262295 The upregulation of signal transducer and activator of transcription 5-dependent microRNA-182 and microRNA-96 promotes ovarian cancer cell proliferation by targeting forkhead box O3 upon leptin stimulation -tissue_expression_up hsa-mir-183 Glioma 23263745 MicroRNA-183 upregulates HIF-1a by targeting isocitrate dehydrogenase 2 (IDH2) in glioma cells -tissue_expression_up hsa-mir-224 Glioma 23263909 Upregulation of microRNA-224 confers a poor prognosis in glioma patients -tissue_expression_up hsa-mir-103 Bladder Neoplasms 23266581 "Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort" -tissue_expression_up hsa-mir-1233 Bladder Neoplasms 23266581 "Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort" -tissue_expression_up hsa-mir-130b Bladder Neoplasms 23266581 "Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort" -tissue_expression_up hsa-mir-135b Bladder Neoplasms 23266581 "Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort" -tissue_expression_up hsa-mir-141 Bladder Neoplasms 23266581 "Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort" -tissue_expression_up hsa-mir-15a Bladder Neoplasms 23266581 "Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort" -tissue_expression_up hsa-mir-182 Bladder Neoplasms 23266581 "Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort" -tissue_expression_up hsa-mir-183 Bladder Neoplasms 23266581 "Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort" -tissue_expression_up hsa-mir-18a Bladder Neoplasms 23266581 "Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort" -tissue_expression_up hsa-mir-190 Bladder Neoplasms 23266581 "Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort" -tissue_expression_up hsa-mir-191 Bladder Neoplasms 23266581 "Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort" -tissue_expression_up hsa-mir-200b Bladder Neoplasms 23266581 "Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort" -tissue_expression_up hsa-mir-21 Bladder Neoplasms 23266581 "Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort" -tissue_expression_up hsa-mir-422b Bladder Neoplasms 23266581 "Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort" -tissue_expression_up hsa-mir-425 Bladder Neoplasms 23266581 "Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort" -tissue_expression_up hsa-mir-449b Bladder Neoplasms 23266581 "Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort" -tissue_expression_up hsa-mir-601 Bladder Neoplasms 23266581 "Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort" -tissue_expression_up hsa-mir-639 Bladder Neoplasms 23266581 "Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort" -tissue_expression_up hsa-mir-644 Bladder Neoplasms 23266581 "Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort" -tissue_expression_up hsa-mir-649 Bladder Neoplasms 23266581 "Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort" -tissue_expression_up hsa-mir-93 Bladder Neoplasms 23266581 "Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort" -tissue_expression_up hsa-mir-96 Bladder Neoplasms 23266581 "Quantitative real-time PCR was applied to measure the levels of 22 microRNAs upregulated in BCA tissue (miR-15a, miR-18a, miR-21, miR-93, miR-96, miR-103, miR-130b, miR-135b, miR-141, miR-182, miR-183, miR-190, miR-191, miR-200b, miR-422b, miR-425, miR-449b, miR-601, miR-639, miR-644, miR-649 and miR-1233) in the marker identification cohort" -tissue_expression_up hsa-mir-21 Pancreatic Neoplasms 23272057 "Here, we show, for the first time, that hypoxia leads to increased expression of VEGF, IL-6, and CSC signature genes Nanog, Oct4 and EZH2 consistent with increased cell migration/invasion and angiogenesis, and the formation of pancreatospheres,concomitant with increased expression of miR-21 and miR-210 in human pancreatic cancer (PC) cells" -tissue_expression_up hsa-mir-210 Pancreatic Neoplasms 23272057 "Here, we show, for the first time, that hypoxia leads to increased expression of VEGF, IL-6, and CSC signature genes Nanog, Oct4 and EZH2 consistent with increased cell migration/invasion and angiogenesis, and the formation of pancreatospheres,concomitant with increased expression of miR-21 and miR-210 in human pancreatic cancer (PC) cells" -tissue_expression_up hsa-mir-372 "Carcinoma, Hepatocellular" 23291979 Upregulation of microRNA-372 associates with tumor progression and prognosis in hepatocellular carcinoma -tissue_expression_up hsa-mir-199a-1 Colorectal Carcinoma 23292866 miR-199a-3p may serve as an efficient biomarker for diagnosis and novel prognostic indicator in colorectal cancer -tissue_expression_up hsa-mir-199a-2 Colorectal Carcinoma 23292866 miR-199a-3p may serve as an efficient biomarker for diagnosis and novel prognostic indicator in colorectal cancer -tissue_expression_up hsa-mir-143 Esophagitis 23297865 "Elevated miR-143, miR-145 and miR-205 expression was observed in oesophageal squamous mucosa of individuals with ulcerative oesophagitis." -tissue_expression_up hsa-mir-145 Esophagitis 23297865 "Elevated miR-143, miR-145 and miR-205 expression was observed in oesophageal squamous mucosa of individuals with ulcerative oesophagitis." -tissue_expression_up hsa-mir-205 Esophagitis 23297865 "Elevated miR-143, miR-145 and miR-205 expression was observed in oesophageal squamous mucosa of individuals with ulcerative oesophagitis." -tissue_expression_up hsa-mir-372 Glioma 23298385 Correlation of microRNA-372 upregulation with poor prognosis in human glioma. -tissue_expression_up hsa-mir-155 Waldenstrom Macroglobulinemia 23301642 The most important changes of microRNA are increased expression of miR-155 and decreased expression of miR-9*. -tissue_expression_up hsa-mir-124 Heart Failure 23307820 "The significant upregulation of miR-124 and miR-134 in the seizure-related stages and children suggested that both can be potential targets for anticonvulsant drugs in the epileptic developing brains, while the different expression patterns of miR-132 and miR-21 may suggest different functions in MTLE pathogenesis." -tissue_expression_up hsa-mir-134 Heart Failure 23307820 "The significant upregulation of miR-124 and miR-134 in the seizure-related stages and children suggested that both can be potential targets for anticonvulsant drugs in the epileptic developing brains, while the different expression patterns of miR-132 and miR-21 may suggest different functions in MTLE pathogenesis." -tissue_expression_up hsa-mir-124a "Aortic Aneurysm, Abdominal" 23316282 "MicroRNAs related to fibrosis (miR-29b),inflammation (miR-124a, miR-146a, miR-155, and miR-223), and endothelium(miR-126, let-7 family members, and miR-21) were significantly upregulated in AAA tissue. " -tissue_expression_up hsa-mir-126 "Aortic Aneurysm, Abdominal" 23316282 "MicroRNAs related to fibrosis (miR-29b),inflammation (miR-124a, miR-146a, miR-155, and miR-223), and endothelium(miR-126, let-7 family members, and miR-21) were significantly upregulated in AAA tissue. " -tissue_expression_up hsa-mir-146a "Aortic Aneurysm, Abdominal" 23316282 "MicroRNAs related to fibrosis (miR-29b),inflammation (miR-124a, miR-146a, miR-155, and miR-223), and endothelium(miR-126, let-7 family members, and miR-21) were significantly upregulated in AAA tissue. " -tissue_expression_up hsa-mir-155 "Aortic Aneurysm, Abdominal" 23316282 "MicroRNAs related to fibrosis (miR-29b),inflammation (miR-124a, miR-146a, miR-155, and miR-223), and endothelium(miR-126, let-7 family members, and miR-21) were significantly upregulated in AAA tissue. " -tissue_expression_up hsa-mir-223 "Aortic Aneurysm, Abdominal" 23316282 "MicroRNAs related to fibrosis (miR-29b),inflammation (miR-124a, miR-146a, miR-155, and miR-223), and endothelium(miR-126, let-7 family members, and miR-21) were significantly upregulated in AAA tissue. " -tissue_expression_up hsa-mir-29b "Aortic Aneurysm, Abdominal" 23316282 "MicroRNAs related to fibrosis (miR-29b),inflammation (miR-124a, miR-146a, miR-155, and miR-223), and endothelium(miR-126, let-7 family members, and miR-21) were significantly upregulated in AAA tissue. " -tissue_expression_up hsa-mir-199a-1 "Carcinoma, Hepatocellular" 23319430 Propofol induces apoptosis of hepatocellular carcinoma cells by upregulation of microRNA-199a expression -tissue_expression_up hsa-mir-199a-2 "Carcinoma, Hepatocellular" 23319430 Propofol induces apoptosis of hepatocellular carcinoma cells by upregulation of microRNA-199a expression -tissue_expression_up hsa-mir-221 "Carcinoma, Hepatocellular" 23320393 Increased MiR-221 expression in hepatocellular carcinoma tissues and its role in enhancing cell growth and inhibiting apoptosis in vitro -tissue_expression_up hsa-mir-192 "Diabetes Mellitus, Type 2" 23372846 "Several highly-expressed islet miRNAs, such as miR-375, have established roles in the regulation of islet function, but others (e.g. miR-27b-3p, miR-192-5p) have not previously been described in the context of islet biology." -tissue_expression_up hsa-mir-27b "Diabetes Mellitus, Type 2" 23372846 "Several highly-expressed islet miRNAs, such as miR-375, have established roles in the regulation of islet function, but others (e.g. miR-27b-3p, miR-192-5p) have not previously been described in the context of islet biology." -tissue_expression_up hsa-mir-375 "Diabetes Mellitus, Type 2" 23372846 "Several highly-expressed islet miRNAs, such as miR-375, have established roles in the regulation of islet function, but others (e.g. miR-27b-3p, miR-192-5p) have not previously been described in the context of islet biology." -tissue_expression_up hsa-mir-29c Schizophrenia 23382797 "RT-PCR validation confirmed that two miRNAs, miR-497 in SZ samples and miR-29c in BD samples, have significantly increased expression when compared to control samples. These results warrant future studies to evaluate the potential of exosome-derived miRNAs to serve as biomarkers of SZ and BD." -tissue_expression_up hsa-mir-497 Schizophrenia 23382797 "RT-PCR validation confirmed that two miRNAs, miR-497 in SZ samples and miR-29c in BD samples, have significantly increased expression when compared to control samples. These results warrant future studies to evaluate the potential of exosome-derived miRNAs to serve as biomarkers of SZ and BD." -tissue_expression_up hsa-mir-21 Thyroid Neoplasms 23416953 "there were significant associations (P<0.05) between BRAF(V600E) and a higher tumor-node-metastasis staging (III/IV), and between miR-21* over-expression and lymph node metastasis." -tissue_expression_up hsa-mir-146b "Carcinoma, Thyroid, Papillary" 23427895 "Fourteen miRNAs were deregulated in FVPTC with a fold change of more than five (up/down), including miRNAs known to be upregulated in PTC (miR-146b-3p, -146-5p, -221, -222 and miR-222-5p) and novel miRNAs (miR-375, -551b, 181-2-3p, 99b-3p)." -tissue_expression_up hsa-mir-221 "Carcinoma, Thyroid, Papillary" 23427895 "Fourteen miRNAs were deregulated in FVPTC with a fold change of more than five (up/down), including miRNAs known to be upregulated in PTC (miR-146b-3p, -146-5p, -221, -222 and miR-222-5p) and novel miRNAs (miR-375, -551b, 181-2-3p, 99b-3p)." -tissue_expression_up hsa-mir-222 "Carcinoma, Thyroid, Papillary" 23427895 "Fourteen miRNAs were deregulated in FVPTC with a fold change of more than five (up/down), including miRNAs known to be upregulated in PTC (miR-146b-3p, -146-5p, -221, -222 and miR-222-5p) and novel miRNAs (miR-375, -551b, 181-2-3p, 99b-3p)." -tissue_expression_up hsa-mir-210 Osteosarcoma 23430441 miR-210 upregulation showed a strong correlation with tumor aggressive progression of pediatric osteosarcoma and could help prognostic screening of patients with this malignancy -tissue_expression_up hsa-mir-146a Melanoma 23441115 "MiR-146a and miR-26a were overexpressed more than threefold in VH from patients with uveal melanomas compared to the other pathological groups (Wilcoxon signed-rank test, p value <0.05)." -tissue_expression_up hsa-mir-26a Melanoma 23441115 "MiR-146a and miR-26a were overexpressed more than threefold in VH from patients with uveal melanomas compared to the other pathological groups (Wilcoxon signed-rank test, p value <0.05)." -tissue_expression_up hsa-mir-182 Colorectal Carcinoma 23474644 Up-regulation of miR-182 expression in colorectal cancer tissues and its prognostic value -tissue_expression_up hsa-mir-200c Head And Neck Neoplasms 23474763 "expression of p21, miR-34a and miR-200c are increased, demonstrating functional p53 reactivation." -tissue_expression_up hsa-mir-34a Head And Neck Neoplasms 23474763 "expression of p21, miR-34a and miR-200c are increased, demonstrating functional p53 reactivation." -tissue_expression_up hsa-mir-145 Esophageal Neoplasms 23477513 patients with either decreased miR-135b or increased miR-145 expression in cancer tissue had improved disease-free survival -tissue_expression_up hsa-mir-17 Glioblastoma 23497354 In glioblastoma a high ratio of miR-17 to miR-221/222 was predictive of better overall survival suggesting that high miR-221/222 expression is more adverse for patients than high miR-17 expression. -tissue_expression_up hsa-mir-221 Glioblastoma 23497354 In glioblastoma a high ratio of miR-17 to miR-221/222 was predictive of better overall survival suggesting that high miR-221/222 expression is more adverse for patients than high miR-17 expression. -tissue_expression_up hsa-mir-625 Colorectal Carcinoma 23506979 High expression of microRNA-625-3p is associated with poor response to first-line oxaliplatin based treatment of metastatic colorectal cancer -tissue_expression_up hsa-mir-17 Stroke 23511639 These data indicate that the miR17-92 cluster plays an important role in mediating neural progenitor cell function and that the Shh signaling pathway is involved in up-regulating miR17-92 cluster expression. -tissue_expression_up hsa-mir-18 Stroke 23511639 These data indicate that the miR17-92 cluster plays an important role in mediating neural progenitor cell function and that the Shh signaling pathway is involved in up-regulating miR17-92 cluster expression. -tissue_expression_up hsa-mir-19a Stroke 23511639 These data indicate that the miR17-92 cluster plays an important role in mediating neural progenitor cell function and that the Shh signaling pathway is involved in up-regulating miR17-92 cluster expression. -tissue_expression_up hsa-mir-19b-1 Stroke 23511639 These data indicate that the miR17-92 cluster plays an important role in mediating neural progenitor cell function and that the Shh signaling pathway is involved in up-regulating miR17-92 cluster expression. -tissue_expression_up hsa-mir-20a Stroke 23511639 These data indicate that the miR17-92 cluster plays an important role in mediating neural progenitor cell function and that the Shh signaling pathway is involved in up-regulating miR17-92 cluster expression. -tissue_expression_up hsa-mir-92-1 Stroke 23511639 These data indicate that the miR17-92 cluster plays an important role in mediating neural progenitor cell function and that the Shh signaling pathway is involved in up-regulating miR17-92 cluster expression. -tissue_expression_up hsa-mir-125b Leukemia 23550646 "miRNAs such as miR-21, miR-125b, miR-155, miR-196, and miR-210 that are critical for the immune response or hypoxia are often overexpressed in cancers and leukemias" -tissue_expression_up hsa-mir-155 Leukemia 23550646 "miRNAs such as miR-21, miR-125b, miR-155, miR-196, and miR-210 that are critical for the immune response or hypoxia are often overexpressed in cancers and leukemias" -tissue_expression_up hsa-mir-196 Leukemia 23550646 "miRNAs such as miR-21, miR-125b, miR-155, miR-196, and miR-210 that are critical for the immune response or hypoxia are often overexpressed in cancers and leukemias" -tissue_expression_up hsa-mir-21 Leukemia 23550646 "miRNAs such as miR-21, miR-125b, miR-155, miR-196, and miR-210 that are critical for the immune response or hypoxia are often overexpressed in cancers and leukemias" -tissue_expression_up hsa-mir-210 Leukemia 23550646 "miRNAs such as miR-21, miR-125b, miR-155, miR-196, and miR-210 that are critical for the immune response or hypoxia are often overexpressed in cancers and leukemias" -tissue_expression_up hsa-mir-146a Ovarian Neoplasms 23554878 "These observations suggest that at least two of the miRNAs, miR-146a and miR-150, up-regulated in omental lesions, stimulate survival and increase drug tolerance." -tissue_expression_up hsa-mir-150 Ovarian Neoplasms 23554878 "These observations suggest that at least two of the miRNAs, miR-146a and miR-150, up-regulated in omental lesions, stimulate survival and increase drug tolerance." -tissue_expression_up hsa-mir-141 Azoospermia 23559187 "Genome-wide microRNA expression profiling in idiopathic non-obstructive azoospermia: significant up-regulation of miR-141, miR-429 and miR-7-1-3p" -tissue_expression_up hsa-mir-429 Azoospermia 23559187 "Genome-wide microRNA expression profiling in idiopathic non-obstructive azoospermia: significant up-regulation of miR-141, miR-429 and miR-7-1-3p" -tissue_expression_up hsa-mir-7-1 Azoospermia 23559187 "Genome-wide microRNA expression profiling in idiopathic non-obstructive azoospermia: significant up-regulation of miR-141, miR-429 and miR-7-1-3p" -tissue_expression_up hsa-mir-7-2 Azoospermia 23559187 "Genome-wide microRNA expression profiling in idiopathic non-obstructive azoospermia: significant up-regulation of miR-141, miR-429 and miR-7-1-3p" -tissue_expression_up hsa-mir-7-3 Azoospermia 23559187 "Genome-wide microRNA expression profiling in idiopathic non-obstructive azoospermia: significant up-regulation of miR-141, miR-429 and miR-7-1-3p" -tissue_expression_up hsa-mir-10b Thyroid Neoplasms 23563786 "The miR-221/222 cluster, miR-10b and miR-92a are highly upregulated in metastatic minimally invasive follicular thyroid carcinoma" -tissue_expression_up hsa-mir-221 Thyroid Neoplasms 23563786 "The miR-221/222 cluster, miR-10b and miR-92a are highly upregulated in metastatic minimally invasive follicular thyroid carcinoma" -tissue_expression_up hsa-mir-222 Thyroid Neoplasms 23563786 "The miR-221/222 cluster, miR-10b and miR-92a are highly upregulated in metastatic minimally invasive follicular thyroid carcinoma" -tissue_expression_up hsa-mir-92a-1 Thyroid Neoplasms 23563786 "The miR-221/222 cluster, miR-10b and miR-92a are highly upregulated in metastatic minimally invasive follicular thyroid carcinoma" -tissue_expression_up hsa-mir-92a-2 Thyroid Neoplasms 23563786 "The miR-221/222 cluster, miR-10b and miR-92a are highly upregulated in metastatic minimally invasive follicular thyroid carcinoma" -tissue_expression_up hsa-mir-155 Breast Neoplasms 23568502 17¦Â-Estradiol up-regulates miR-155 expression and reduces TP53INP1 expression in MCF-7 breast cancer cells -tissue_expression_up hsa-mir-146b "Carcinoma, Thyroid, Papillary" 23569392 "In addition, the miR-146b expression level was significantly higher in the massive extrathyroidal invasion group than in the minimal extrathyroidal invasion group" -tissue_expression_up hsa-mir-145 Glioblastoma 23577178 "Most importantly, higher hsa-miR-145 expression in GBM tumors yielded significantly better survival (p<0.005) in a subset of patients thus validating it as a genuine tumor suppressor miRNA." -tissue_expression_up hsa-mir-146a Sepsis 23596477 We observed a significant increase in miR-146a expression in the initial cohort of 6 non-sepsis-SIRS patients compared to the 4 sepsis patients(P=0.01) -tissue_expression_up hsa-mir-132 Inflammatory Bowel Diseases 23598815 MiR-132 levels are higher in inflamed compared with apparently quiescent intestinal biopsies from patients with IBD. -tissue_expression_up hsa-let-7i Ankylosing Spondylitis 23607629 "In the functional studies, the increased let-7i expression facilitated the T helper type 1 (IFN-¦Ã) immune response in T cells." -tissue_expression_up hsa-mir-203 Psoriasis 23608026 "MiR-203 is a miRNA preferentially expressed in the skin, and an important regulator of keratinocyte differentiation. MiR-203 has been implicated in skin diseases, in particular in psoriasis in which it is overexpressed, and in basal cell carcinoma where it acts as a tumor suppressor miRNA." -tissue_expression_up hsa-mir-143 "Leukemia, Lymphocytic, Chronic, B-Cell" 23615967 "Significant upregulation of miR-150, miR-29c, miR-143 and miR-223 and downregulation of miR-15a was found in mutated versus unmutated CLL, with miR-15a showing the highest fold difference." -tissue_expression_up hsa-mir-150 "Leukemia, Lymphocytic, Chronic, B-Cell" 23615967 "Significant upregulation of miR-150, miR-29c, miR-143 and miR-223 and downregulation of miR-15a was found in mutated versus unmutated CLL, with miR-15a showing the highest fold difference." -tissue_expression_up hsa-mir-223 "Leukemia, Lymphocytic, Chronic, B-Cell" 23615967 "Significant upregulation of miR-150, miR-29c, miR-143 and miR-223 and downregulation of miR-15a was found in mutated versus unmutated CLL, with miR-15a showing the highest fold difference." -tissue_expression_up hsa-mir-29c "Leukemia, Lymphocytic, Chronic, B-Cell" 23615967 "Significant upregulation of miR-150, miR-29c, miR-143 and miR-223 and downregulation of miR-15a was found in mutated versus unmutated CLL, with miR-15a showing the highest fold difference." -tissue_expression_up hsa-mir-181a Breast Neoplasms 23656790 "We report that miR-181a and miR-181b were overexpressed in more aggressive breast cancers, and their expression correlates inversely with ATM levels." -tissue_expression_up hsa-mir-181b Breast Neoplasms 23656790 "We report that miR-181a and miR-181b were overexpressed in more aggressive breast cancers, and their expression correlates inversely with ATM levels." -tissue_expression_up hsa-mir-210 Heart Failure 23660476 miR-210 and miR-30a were elevated in the HF and fetus groups. -tissue_expression_up hsa-mir-30a Heart Failure 23660476 miR-210 and miR-30a were elevated in the HF and fetus groups. -tissue_expression_up hsa-mir-10b Ovarian Neoplasms 23670532 Loss of HOXD10 expression induced by upregulation of miR-10b accelerates the migration and invasion activities of ovarian cancer cells. -tissue_expression_up hsa-mir-155 Allergic Rhinitis 23704072 "Subjects with current allergic rhinitis symptoms had increased levels of miR-155, miR-205, and miR-498, but reduced levels of let-7e." -tissue_expression_up hsa-mir-205 Allergic Rhinitis 23704072 "Subjects with current allergic rhinitis symptoms had increased levels of miR-155, miR-205, and miR-498, but reduced levels of let-7e." -tissue_expression_up hsa-mir-498 Allergic Rhinitis 23704072 "Subjects with current allergic rhinitis symptoms had increased levels of miR-155, miR-205, and miR-498, but reduced levels of let-7e." -tissue_expression_up hsa-mir-328 Atrial Fibrillation 23710743 miR-328 expression is significantly increased in patients with AF -tissue_expression_up hsa-mir-130a Pulmonary Hypertension 23717609 "We identified several novel downregulated miRNAs (miR-451, miR-1246) and upregulated miRNAs (miR-23b, miR-130a and miR-191) in the circulation of PH subjects." -tissue_expression_up hsa-mir-191 Pulmonary Hypertension 23717609 "We identified several novel downregulated miRNAs (miR-451, miR-1246) and upregulated miRNAs (miR-23b, miR-130a and miR-191) in the circulation of PH subjects." -tissue_expression_up hsa-mir-23b Pulmonary Hypertension 23717609 "We identified several novel downregulated miRNAs (miR-451, miR-1246) and upregulated miRNAs (miR-23b, miR-130a and miR-191) in the circulation of PH subjects." -tissue_expression_up hsa-mir-192 "Adenocarcinoma, Esophageal" 23724052 "6 miRNAs (up-regulated: miR-194, miR-31, miR-192, and miR-200a; down-regulated: miR-203 and miR-205) in EAC" -tissue_expression_up hsa-mir-194 "Adenocarcinoma, Esophageal" 23724052 "6 miRNAs (up-regulated: miR-194, miR-31, miR-192, and miR-200a; down-regulated: miR-203 and miR-205) in EAC" -tissue_expression_up hsa-mir-200a "Adenocarcinoma, Esophageal" 23724052 "6 miRNAs (up-regulated: miR-194, miR-31, miR-192, and miR-200a; down-regulated: miR-203 and miR-205) in EAC" -tissue_expression_up hsa-mir-203 "Adenocarcinoma, Esophageal" 23724052 "6 miRNAs (up-regulated: miR-194, miR-31, miR-192, and miR-200a; down-regulated: miR-203 and miR-205) in EAC" -tissue_expression_up hsa-mir-205 "Adenocarcinoma, Esophageal" 23724052 "6 miRNAs (up-regulated: miR-194, miR-31, miR-192, and miR-200a; down-regulated: miR-203 and miR-205) in EAC" -tissue_expression_up hsa-mir-31 "Adenocarcinoma, Esophageal" 23724052 "6 miRNAs (up-regulated: miR-194, miR-31, miR-192, and miR-200a; down-regulated: miR-203 and miR-205) in EAC" -tissue_expression_up hsa-mir-130b Inflammation 23733276 "Statistical analysis considering liver donor meta-data including correction for multiple testing revealed strongly elevated levels of miR-21, miR-34a, miR-130b, and miR-132 in cholestatic liver and of miR-21 and miR-130b during inflammation, as indicated by elevated C-reactive protein levels in serum." -tissue_expression_up hsa-mir-132 Inflammation 23733276 "Statistical analysis considering liver donor meta-data including correction for multiple testing revealed strongly elevated levels of miR-21, miR-34a, miR-130b, and miR-132 in cholestatic liver and of miR-21 and miR-130b during inflammation, as indicated by elevated C-reactive protein levels in serum." -tissue_expression_up hsa-mir-21 Inflammation 23733276 "Statistical analysis considering liver donor meta-data including correction for multiple testing revealed strongly elevated levels of miR-21, miR-34a, miR-130b, and miR-132 in cholestatic liver and of miR-21 and miR-130b during inflammation, as indicated by elevated C-reactive protein levels in serum." -tissue_expression_up hsa-mir-34a Inflammation 23733276 "Statistical analysis considering liver donor meta-data including correction for multiple testing revealed strongly elevated levels of miR-21, miR-34a, miR-130b, and miR-132 in cholestatic liver and of miR-21 and miR-130b during inflammation, as indicated by elevated C-reactive protein levels in serum." -tissue_expression_up hsa-mir-221 Obesity 23756832 Human adipose microRNA-221 is upregulated in obesity and affects fat metabolism downstream of leptin and TNF-alpha -tissue_expression_up hsa-mir-101-1 Esophageal Neoplasms 23761828 upregulated -tissue_expression_up hsa-mir-101-2 Esophageal Neoplasms 23761828 upregulated -tissue_expression_up hsa-mir-130a Esophageal Neoplasms 23761828 upregulated -tissue_expression_up hsa-mir-130b Esophageal Neoplasms 23761828 upregulated -tissue_expression_up hsa-mir-143 Esophageal Neoplasms 23761828 upregulated -tissue_expression_up hsa-mir-15a Esophageal Neoplasms 23761828 upregulated -tissue_expression_up hsa-mir-196b Esophageal Neoplasms 23761828 upregulated -tissue_expression_up hsa-mir-200a Esophageal Neoplasms 23761828 upregulated -tissue_expression_up hsa-mir-210 Esophageal Neoplasms 23761828 upregulated -tissue_expression_up hsa-mir-27a Esophageal Neoplasms 23761828 upregulated -tissue_expression_up hsa-mir-28 Esophageal Neoplasms 23761828 miR-28-3p: upregulated -tissue_expression_up hsa-mir-31 Esophageal Neoplasms 23761828 upregulated -tissue_expression_up hsa-mir-452 Esophageal Neoplasms 23761828 upregulated -tissue_expression_up hsa-mir-99b Esophageal Neoplasms 23761828 upregulated -tissue_expression_up hsa-mir-192 Ovarian Neoplasms 23766361 "The clear cell histotype is characterized by a five-fold (log scale) higher expression of miR-30a and miR-30a*, while mucinous histotype has five-fold (log scale) higher levels of miR-192/194. Furthermore a mucinous-specific regulatory loop involving miR-192/194 cluster and a differential regulation of E2F3 in clear cell histotype were identified." -tissue_expression_up hsa-mir-194-1 Ovarian Neoplasms 23766361 "The clear cell histotype is characterized by a five-fold (log scale) higher expression of miR-30a and miR-30a*, while mucinous histotype has five-fold (log scale) higher levels of miR-192/194. Furthermore a mucinous-specific regulatory loop involving miR-192/194 cluster and a differential regulation of E2F3 in clear cell histotype were identified." -tissue_expression_up hsa-mir-194-2 Ovarian Neoplasms 23766361 "The clear cell histotype is characterized by a five-fold (log scale) higher expression of miR-30a and miR-30a*, while mucinous histotype has five-fold (log scale) higher levels of miR-192/194. Furthermore a mucinous-specific regulatory loop involving miR-192/194 cluster and a differential regulation of E2F3 in clear cell histotype were identified." -tissue_expression_up hsa-mir-30a Ovarian Neoplasms 23766361 "The clear cell histotype is characterized by a five-fold (log scale) higher expression of miR-30a and miR-30a*, while mucinous histotype has five-fold (log scale) higher levels of miR-192/194. Furthermore a mucinous-specific regulatory loop involving miR-192/194 cluster and a differential regulation of E2F3 in clear cell histotype were identified." -tissue_expression_up hsa-mir-34a Breast Neoplasms 23771315 Synergistic effects of curcumin with emodin against the proliferation and invasion of breast cancer cells through upregulation of mir-34a. -tissue_expression_up hsa-mir-874 Gastric Neoplasms 23800944 "These results provide a mechanism by which AQP3 is upregulated, as well as highlight the importance of miR-874 in gastric cancer development and progression." -tissue_expression_up hsa-mir-181c Gastric Neoplasms 23803080 "The expression of miR-181c is upregulated in GC tissues and plasma, and the miR-181c expression level in GC plasma is positively correlated to that in the corresponding cancer tissues. Plasma miR-181c is possibly a new serological marker for GC diagnosis." -tissue_expression_up hsa-mir-107 Glioma 23811124 Low-expression of microRNA-107 inhibits cell apoptosis in glioma by upregulation of SALL4. -tissue_expression_up hsa-mir-19a Glioma 23824915 miR-19a and miR-19b overexpression in gliomas. -tissue_expression_up hsa-mir-19b Glioma 23824915 miR-19a and miR-19b overexpression in gliomas. -tissue_expression_up hsa-mir-146b Intestinal Schistosomiasis 23825609 "miRNAs exhibiting a peak expression in the late phase of infection (dpi 45), such as mmu-miR-223, mmu-miR-146a/b, mmu-miR-155, mmu-miR-34c, mmu-miR-199, and mmu-miR-134, may represent a molecular ignature of the development of schistosomal hepatopathy." -tissue_expression_up hsa-mir-124 Stroke 23826665 The level of miR-124 is significantly increased in ischemic penumbra as compared with that in nonischemic area of MACO mice. -tissue_expression_up hsa-mir-301a Gastric Neoplasms 23832550 "miR-301a overexpression correlated with TNM stage and prognosis,suggesting that miR-301a is involved in cellular clone formation, migration, and invasion in vitro and may play an important role in the clinical progression and prognosis of gastric cancer." -tissue_expression_up hsa-mir-200b Gastric Neoplasms 23851184 Diallyl disulfide suppresses proliferation and induces apoptosis in human gastric cancer through Wnt-1 signaling pathway by up-regulation of miR-200b and miR-22. -tissue_expression_up hsa-mir-22 Gastric Neoplasms 23851184 Diallyl disulfide suppresses proliferation and induces apoptosis in human gastric cancer through Wnt-1 signaling pathway by up-regulation of miR-200b and miR-22. -tissue_expression_up hsa-mir-155 "Carcinoma, Hepatocellular" 23863669 MicroRNA-155 is over-expressed in primary HCC with tumor recurrence and may serve as a novel biomarker for tumor recurrence and survival of HCC patients after LT. The detection of microRNA-155 is of clinical significance in HCC. -tissue_expression_up hsa-mir-675 "Carcinoma, Hepatocellular" 23864307 Expression of the miR-675 in hepatocellular carcinoma links a dramatic upregulation of proliferative and growth capacity with inhibition of motility in HCC cells. -tissue_expression_up hsa-mir-21 Gastric Neoplasms 23888942 Oxidative stress upregulates PDCD4 expression in patients with gastric cancer via miR-21. -tissue_expression_up hsa-mir-27 Hepatitis C Virus Infection 23897856 Hepatitis C virus induced up-regulation of microRNA-27: a novel mechanism for hepatic steatosis. -tissue_expression_up hsa-mir-143 Lung Neoplasms 23904792 "The up-regulated miR-143 in lung cancer could significantly inhibit cell migration and invasion, and this might work through targeting CD44v3, which was newly identified by us." -tissue_expression_up hsa-mir-203 Ovarian Neoplasms 23918241 Upregulation of microRNA-203 is associated with advanced tumor progression and poor prognosis in epithelial ovarian cancer. -tissue_expression_up hsa-mir-182 Prostate Neoplasms 23936432 Inhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR-182 and p21. -tissue_expression_up hsa-mir-31 Choriocarcinoma 23946296 MicroRNA-31 predicts the presence of lymph node metastases and survival in patients with lung adenocarcinoma. -tissue_expression_up hsa-mir-138 "Carcinoma, Bladder" 23946872 "Within this group, let-7b and let-7i exhibited decreased expression, while miR-1290 and miR-138 displayed increased expression levels in gemcitabine-resistant cells." -tissue_expression_up hsa-mir-132 Inflammation 23951048 Chronic ethanol feeding up-regulated miR-155 and miR-132 expression in mouse cerebellum. -tissue_expression_up hsa-mir-10a Breast Neoplasms 23968733 Increased expression of miR-126 and miR-10a predict prolonged relapse-free time of primary oestrogen receptor-positive breast cancer following tamoxifen treatment. -tissue_expression_up hsa-mir-126 Breast Neoplasms 23968733 Increased expression of miR-126 and miR-10a predict prolonged relapse-free time of primary oestrogen receptor-positive breast cancer following tamoxifen treatment. -tissue_expression_up hsa-mir-18b Breast Neoplasms 23970382 MicroRNA-18b is upregulated in breast cancer and modulates genes involved in cell migration. -tissue_expression_up hsa-mir-215 Gastric Neoplasms 23981575 Frequently up-regulated miR-215 in gastric cancer may influence cell proliferation by targeting RB1. -tissue_expression_up hsa-mir-9 Lung Neoplasms 24019037 "MiR-9 was up-regulated in non-small cell lung cancer tissues and correlated with adverse clinical features and unfavorable survival, indicating that miR-9 might be involved in non-small lung cancer progression and could serve as a promising biomarker for further risk stratification in the treatment of this cancer." -tissue_expression_up hsa-mir-26b Alzheimer Disease 24027266 "MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry,tau-phosphorylation, and apoptosis in postmitotic neurons." -tissue_expression_up hsa-mir-126 "Carcinoma, Cervical" 24037526 Repression of miR-126 and upregulation of adrenomedullin in the stromal endothelium by cancer-stromal cross talks confers angiogenesis of cervical cancer. -tissue_expression_up hsa-mir-214 Pediatric Osteosarcoma 24038809 Our data offer evidence that upregulated expression of miR-214 may be linked to tumor progression and adverse prognosis in pediatric osteosarcoma.Further investigation in prospective studies would appear warranted. -tissue_expression_up hsa-mir-1 Myocardial Infarction 24046434 "Consistent with previous publications, cardiac specific miR-1 and miR-133a were up-regulated in STEMI patients compared with healthy controls (both, P < 0.0001)" -tissue_expression_up hsa-mir-182 "Carcinoma, Colon" 24053448 "Our data suggest that miR-182 targets the anti-angiogenic factor TSP-1 and that anti-miR-182 determines an upregulation of TSP-1 expression in colon cancer cells. Moreover, anti-miR-182 exerts a transcriptional regulatory mechanism of tsp-1 modulating Egr-1 and Sp-1 function. Anti-miR-182 could be used to restore TSP-1 expression in order to contrast angiogenic and invasive events in CRC." -tissue_expression_up hsa-mir-9 Glioma 24122417 Increased expression of microRNA-9 predicts an unfavorable prognosis in human glioma. -tissue_expression_up hsa-mir-21 "Carcinoma, Colon" 24122631 High miR-21 expression from FFPE tissues is associated with poor survival and response to adjuvant chemotherapy in colon cancer. -tissue_expression_up hsa-mir-222 "Carcinoma, Hepatocellular" 24124720 "Serum miR-222, upregulated in HCC, maybe helpful in prognosis of HCC patients." -tissue_expression_up hsa-mir-222 Ovarian Neoplasms 24137356 miR-222 is upregulated in epithelial ovarian cancer and promotes cell proliferation by downregulating P27kip1. -tissue_expression_up hsa-mir-32 "Muscular Dystrophy, Facioscapulohumeral" 24145033 "Twenty-one microRNAs (miR-1, miR-7, miR-15a, miR-22, miR-30e, miR-32, miR-107, miR-133a, miR-133b, miR-139, miR-152, miR-206, miR-223, miR-302b, miR-331, miR-362, miR-365, miR-382, miR-496, miR-532, miR-654, and miR-660) were up-regulated" -tissue_expression_up hsa-mir-525 Neoplasms [unspecific] 24147004 "The transient up-regulation of miR-525-3p, and the resultant repression of its direct targets ARRB1, TXN1 and HSPA9, is required for cell survival following irradiation. The conserved function of miR-525-3p across several cell types makes this microRNA pathway a promising target for modifying the efficacy of radiotherapy." -tissue_expression_up hsa-mir-183 Colorectal Carcinoma 24150523 "The increased expression of miR-183 is closely related to advanced clinical stage, lymph node and distant metastases, and poor prognosis of CRC,indicating that miR-183 may serve as a predictive biomarker for the prognosis or the aggressiveness of CRC." -tissue_expression_up hsa-mir-155 Rheumatoid Arthritis 24151514 "An inflammatory milieu may alter miRNA expression profiles in rheumatoid arthritis. miR-155 is upregulated in RA-FLS, and it may be a protective factor against the inflammatory effect in part by attenuating expression of IKBKE." -tissue_expression_up hsa-mir-221 Glioblastoma 24155920 "A number of changes in the levels of microRNAs were detected in differentiating GICs, including over-expression of hsa-miR-21, hsa-miR-29a, hsa-miR-29b, hsa-miR-221 and hsa-miR-222, and down-regulation of hsa-miR-93 and hsa-miR-106a." -tissue_expression_up hsa-mir-222 Glioblastoma 24155920 "A number of changes in the levels of microRNAs were detected in differentiating GICs, including over-expression of hsa-miR-21, hsa-miR-29a, hsa-miR-29b, hsa-miR-221 and hsa-miR-222, and down-regulation of hsa-miR-93 and hsa-miR-106a." -tissue_expression_up hsa-mir-125b Glioblastoma 24169356 High-level expression of miR-125b is associated with poor outcomes of GMB. MiR-125b may have an oncogenic role in GMB cells by promoting cell proliferation and inhibiting apoptosis. -tissue_expression_up hsa-mir-518b Chondrosarcoma 24173143 Gallic acid induces apoptosis and inhibits cell migration by upregulating miR-518b in SW1353 human chondrosarcoma cells. -tissue_expression_up hsa-mir-122 "Carcinoma, Renal Cell" 24175769 The up-regulation of miR-122 may play an important role in the progress of renal cancer through activating PI3K/Akt signal pathway and could be a potential molecular target for anti-cancer therapeutics. -tissue_expression_up hsa-mir-198 "Carcinoma, Esophageal" 24175778 miR-198 overexpression is involved in the poor prognosis of esophageal cancer and can be used as a biomarker for selection of cases requiring especial attention. -tissue_expression_up hsa-mir-29a Neoplasms [unspecific] 24210072 MicroRNA-29a upregulates MMP2 in oral squamous cell carcinoma to promote cancer invasion and anti-apoptosis. -tissue_expression_up hsa-mir-31 "Squamous Cell Carcinoma, Oral" 24238414 The up-regulated level of microRNA-31 expression may be related to the pathogenesis of OSCC. -tissue_expression_up hsa-mir-150 Chronic Heart Failure 24239242 MicroRNA-150 counteracts ADIPOR2 up-regulation in CHF and thus may contribute to adiponectin resistance. Targeting microRNA-150 may be a future strategy to restore cardioprotective adiponectin effects. -tissue_expression_up hsa-mir-424 Prostate Neoplasms 24244675 MiR-424/503-mediated Rictor upregulation promotes tumor progression. -tissue_expression_up hsa-mir-503 Prostate Neoplasms 24244675 MiR-424/503-mediated Rictor upregulation promotes tumor progression. -tissue_expression_up hsa-mir-21 Colorectal Carcinoma 24265822 The present findings suggest that high expression of miR-21 might predict poor prognosis in patients with colorectal cancer. -tissue_expression_up hsa-mir-25 Colorectal Carcinoma 24293092 The expression of miR-25 is increased in colorectal cancer and is associated with patient prognosis. -tissue_expression_up hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 24293118 Our data suggest a novel molecular mechanism in which inhibition of microRNA-21 and upregulation of PTEN mediate the anticancer activities of curcumin in NSCLC cells. Suppression of microRNA-21 may thus have therapeutic benefits against this malignancy. -tissue_expression_up hsa-mir-655 "Squamous Cell Carcinoma, Esophageal" 24314023 Mir-655 up-regulation suppresses cell invasion by targeting pituitary tumor-transforming gene-1 in esophageal squamous cell carcinoma. -tissue_expression_up hsa-mir-143 "Diabetes Mellitus, Type 2" 24333576 Adipocyte-derived factors impair insulin signaling in differentiated human vascular smooth muscle cells via the upregulation of miR-143. -tissue_expression_up hsa-mir-125b Amyotrophic Lateral Sclerosis 24336079 "We identified upregulation of selected immune-enriched miRNAs, recognizing miR-22, miR-155, miR-125b and miR-146b among the most highly modulated." -tissue_expression_up hsa-mir-146b Amyotrophic Lateral Sclerosis 24336079 "We identified upregulation of selected immune-enriched miRNAs, recognizing miR-22, miR-155, miR-125b and miR-146b among the most highly modulated." -tissue_expression_up hsa-mir-23b Lymphoma 24356489 We found that miR-23a & miR-23b were up-regulated in radiation induced thymic lymphoma tissue samples. -tissue_expression_up hsa-mir-210 Glioma 24382515 MicroRNA-210 overexpression predicts poorer prognosis in glioma patients. -tissue_expression_up hsa-mir-98 Glioma 24392454 Overexpression of RKIP inhibits cell invasion in glioma cell lines through upregulation of miR-98. -tissue_expression_up hsa-mir-128 Salmonellosis 24415783 "Salmonella can upregulate intestinal epithelial miR-128 expression,which, in turn, decreases levels of epithelial cell-secreted M-CSF and M-CSF-induced macrophage recruitment. mir-9-5p" -tissue_expression_up hsa-mir-155 "Squamous Cell Carcinoma, Oral" 24439918 "In OSSC, upregulation of miR-155 correlated with the histologic grade and can be used as a potential prognostic biomarker." -tissue_expression_up hsa-mir-146 "Carcinoma, Lung, Non-Small-Cell" 24448024 microRNA-146 up-regulation predicts the prognosis of non-small cell lung cancer by miRNA in situ hybridization. -tissue_expression_up hsa-mir-17 Melanoma 24462553 "We show that miRNAs of the miR-17-92 cluster (miR-20a2, miR-92a1, miR-17 and miR-18a), miR-126, miR-182, miR-210 and miR-214 are upregulated and their respective target genes (RUNX1, HIF1A, TGFBR2, THBS1 and JAK2) are down-regulated in melanoma." -tissue_expression_up hsa-mir-214 Melanoma 24462553 "We show that miRNAs of the miR-17-92 cluster (miR-20a2, miR-92a1, miR-17 and miR-18a), miR-126, miR-182, miR-210 and miR-214 are upregulated and their respective target genes (RUNX1, HIF1A, TGFBR2, THBS1 and JAK2) are down-regulated in melanoma." -tissue_expression_up hsa-mir-214 Ovarian Neoplasms 24479883 "Members of the miR-200 family, miR-182, miR-214 and miR-221 are frequently up-regulated, whereas miR-100, let-7i, miR-199a, miR-125b, mir-145 and miR-335 are often down-regulated in ovarian cancer compared with normal ovarian tissue." -tissue_expression_up hsa-mir-30a Ovarian Neoplasms 24479883 "Clear cell carcinoma has a significantly higher expression of miR-30a and miR-30a*, whereas mucinous histotype has elevated levels of miR-192/194." -tissue_expression_up hsa-mir-888 Breast Neoplasms 24480745 "As a potential role in intercellular adhesiveness and maintenance of malignant tissue architecture, the results indicate that miR-888 is a repressor of the AJ pathway in MCF-7 cells and that up-regulation of miR-888 contributes to aggressiveness in MCF-7 SP cells." -tissue_expression_up hsa-mir-31 Oral Neoplasms 24480806 miR-31 is upregulated in oral premalignant epithelium and contributes to the immortalization of normal oral keratinocytes. -tissue_expression_up hsa-mir-135b "Carcinoma, Endometrioid Endometrial" 24491411 "Quantitative reverse-transcriptase PCR identified 8 EEC-associated miRNAs in tissue (upregulated: miR-499, miR-135b, miR-205, downregulated: miR-10b, miR-195, miR-30a-5p, miR-30a-3p and miR-21)." -tissue_expression_up hsa-mir-145 Endometriosis 24495683 "Up-regulation of mir-29c, mir-200a, mir-145 in the endometrial tissue might play a role in endometriosis associated infertility." -tissue_expression_up hsa-mir-200a Endometriosis 24495683 "Up-regulation of mir-29c, mir-200a, mir-145 in the endometrial tissue might play a role in endometriosis associated infertility." -tissue_expression_up hsa-mir-29c Endometriosis 24495683 "Up-regulation of mir-29c, mir-200a, mir-145 in the endometrial tissue might play a role in endometriosis associated infertility." -tissue_expression_up hsa-mir-143 Allergic Rhinitis 24513959 "Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR." -tissue_expression_up hsa-mir-143 Asthma 24513959 "Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR." -tissue_expression_up hsa-mir-187 Allergic Rhinitis 24513959 "Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR." -tissue_expression_up hsa-mir-187 Asthma 24513959 "Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR." -tissue_expression_up hsa-mir-498 Allergic Rhinitis 24513959 "Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR." -tissue_expression_up hsa-mir-498 Asthma 24513959 "Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR." -tissue_expression_up hsa-mir-874 Allergic Rhinitis 24513959 "Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR." -tissue_expression_up hsa-mir-874 Asthma 24513959 "Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR." -tissue_expression_up hsa-mir-886 Allergic Rhinitis 24513959 "Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR." -tissue_expression_up hsa-mir-886 Asthma 24513959 "Downregulation of miR-18a, miR-126, let-7e, miR-155, and miR-224 and upregulation of miR-498, miR-187, miR-874, miR-143, and miR-886-3p were observed in asthmatic patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR." -tissue_expression_up hsa-mir-182 "Carcinoma, Lung, Non-Small-Cell" 24575749 "In patients with SCC and in stage II patients, high tumor cell miR-182 expression is an independent positive prognostic factor." -tissue_expression_up hsa-mir-25 "Carcinoma, Hepatocellular" 24593846 Our data suggests that the overexpression of miR-25 in HCC tissues is of predictive value on poor prognosis. -tissue_expression_up hsa-mir-206 Alzheimer Disease 24604632 "We now report that miR-206 is upregulated in the hippocampal tissue, cerebrospinal fluid, and plasma of embryonic APP/PS1 transgenic mice." -tissue_expression_up hsa-mir-93 Breast Neoplasms 24606013 These results suggest that overexpression of miR-93 in FFPE tissues may serve as an indispensable source for biomarker discovery and validation in breast cancer patients. -tissue_expression_up hsa-mir-126 Asthma 24615202 In mice models of asthma it has been found that increased levels of miR-21 and miR-126 -tissue_expression_up hsa-mir-630 Gastric Neoplasms 24621930 Increased microRNA-630 expression in gastric cancer is associated with poor overall survival. -tissue_expression_up hsa-mir-196a Pancreatic Intraductal Papillary Mucinous Neoplasms 24622064 Elevated expression of miR-196a in pancreatic juice samples is predictive of intestinal-type IPMNs. -tissue_expression_up hsa-mir-125b Melanoma 24635082 "MLK3 is upregulated in metastatic melanoma, and regulates cell proliferation and invasion in melanoma cells. MLK3 is a direct target of miR-125b." -tissue_expression_up hsa-mir-149 Lung Fibrosis 24641842 Down-regulation of miR-149 and up-regulation of IL-6 might be involved in the progression of silica-induced pulmonary fibrosis; miR-149 could negatively regulate IL-6 expression. -tissue_expression_up hsa-mir-17 Osteosarcoma 24645838 Upregulation of microRNA-17-92 cluster associates with tumor progression and prognosis in osteosarcoma. -tissue_expression_up hsa-mir-106a Colorectal Carcinoma 24670448 "plasma miR-106a is up-regulated in CRC patients, suggesting its potential value for the diagnosis of CRC." -tissue_expression_up hsa-mir-155 "Squamous Cell Carcinoma, Oral" 24692283 "MiRNA-155 was overexpressed in OSCC and it was located in the cancer nest, inflammatory area, and vascular endothelium of OSCC. High miRNA-155 expression level in ACF may predict poor prognosis in patients with OSCC." -tissue_expression_up hsa-mir-1224 Acute Kidney Failure 24695114 "Ischemia-reperfusion caused highly reproducible, progressive, concordant elevation of miR-714, miR-1188, miR-1897-3p, miR-877*, and miR-1224 in plasma and kidneys at 3, 6 and 24 hours after acute kidney injury compared to the sham-operated mice (nâ€?â€?)." -tissue_expression_up hsa-mir-25 "Carcinoma, Ovarian" 24696291 "The increased expression of miR-25 is closely related to poor prognosis of EOC, indicating that miR-25 may serve as a predictive biomarker for the prognosis of EOC." -tissue_expression_up hsa-mir-98 Breast Neoplasms 24696733 Over-expression of miR-98 in FFPE tissues might serve as a valuable source for biomarker discovery in breast cancer patients. -tissue_expression_up hsa-mir-218 "Adenocarcinoma, Lung" 24705471 ADAM9 up-regulates N-cadherin via miR-218 suppression in lung adenocarcinoma cells. -tissue_expression_up hsa-mir-199a Colorectal Carcinoma 24711074 MiR-199a-5p loss up-regulated DDR1 aggravated colorectal cancer by activating epithelial-to-mesenchymal transition related signaling. -tissue_expression_up hsa-let-7b Infertility 24711889 "Mir-100, let-7b levels were significantly higher than those in control group (P=0.008 and P=0.009, respectively)." -tissue_expression_up hsa-mir-223 Knee Osteoarthritis 24727161 Peroxisomal dysfunction is associated with up-regulation of apoptotic cell death via miR-223 induction in knee osteoarthritis patients with type 2 diabetes mellitus. -tissue_expression_up hsa-mir-4284 Glioblastoma 24732116 "A novel berbamine derivative inhibits cell viability and induces apoptosis in cancer stem-like cells of human glioblastoma, via up-regulation of miRNA-4284 and JNK/AP-1 signaling." -tissue_expression_up hsa-mir-21 Acute Lung Injury 24736893 miR-21 was upregulated in the OA group throughout the 24 h following OA challenge. -tissue_expression_up hsa-mir-1246 Neuroblastoma 24739954 Parallel mRNA and microRNA profiling of HEV71-infected human neuroblastoma cells reveal the up-regulation of miR-1246 in association with DLG3 repression. -tissue_expression_up hsa-mir-196a Osteosarcoma 24747591 "Our present data indicate the involvement of miR-196a and miR-196b upregulation in the pathogenesis of osteosarcoma. More importantly, the altered levels of circulating miR-196a and miR-196b might have great potential to serve as novel and non-invasive prognostic factors for this malignancy." -tissue_expression_up hsa-mir-196b Osteosarcoma 24747591 "Our present data indicate the involvement of miR-196a and miR-196b upregulation in the pathogenesis of osteosarcoma. More importantly, the altered levels of circulating miR-196a and miR-196b might have great potential to serve as novel and non-invasive prognostic factors for this malignancy." -tissue_expression_up hsa-mir-21 "Carcinoma, Esophageal" 24756761 Nicotine upregulates microRNA-21 and promotes TGF-¦Â-dependent epithelial-mesenchymal transition of esophageal cancer cells. -tissue_expression_up hsa-mir-378 Obesity 24771406 "TNF-¦Á, IL-6, and leptin upregulated miR-378 expression indicating that miR-378 probably is a novel mediator in the development of insulin resistance related to obesity." -tissue_expression_up hsa-mir-21 "Carcinoma, Breast" 24781337 Higher miR-21 expression in invasive breast carcinomas is associated with positive estrogen and progesterone receptor status in patients from Serbia. -tissue_expression_up hsa-mir-183 "Adenocarcinoma, Lung" 24805982 Up-regulation of microRNA-183-3p is a potent prognostic marker for lung adenocarcinoma of female non-smokers. -tissue_expression_up hsa-mir-26b "Adenocarcinoma, Lung" 24815696 Huaier suppresses proliferation and induces apoptosis in human pulmonary cancer cells via upregulation of miR-26b-5p. -tissue_expression_up hsa-mir-196a "Carcinoma, Cervical" 24817935 Heterogeneity of microRNAs expression in cervical cancer cells: over-expression of miR-196a. -tissue_expression_up hsa-mir-23b "Leukemia, Myeloid, Acute" 24828865 MicroRNA-26a-5p and microRNA-23b-3p up-regulate peroxiredoxin III in acute myeloid leukemia. -tissue_expression_up hsa-mir-26a "Leukemia, Myeloid, Acute" 24828865 MicroRNA-26a-5p and microRNA-23b-3p up-regulate peroxiredoxin III in acute myeloid leukemia. -tissue_expression_up hsa-mir-155 "Carcinoma, Lung, Non-Small-Cell" 24854560 High expression of miR-155 represents a valuable marker of poor clinical outcomes in patients with stage III NSCLC. -tissue_expression_up hsa-mir-9 Ovarian Neoplasms 24870723 The present study provided evidence that curcumin exerts its cytotoxic effects against SKOV3 ovarian cancer cells largely through upregulation of miR-9 and subsequent modulation of Akt/FOXO1 axis. Further studies are needed to identify direct targets of miR-9 that mediate the anticancer effects of curcumin in ovarian cancer cells. -tissue_expression_up hsa-mir-155 "Carcinoma, Colon" 24888652 "The expression of miR-155 is up-regulated in colon cancer tissue. A combination of miR-155 level assay in colon cancer tissue and the serum CEA level both pre- and postoperatively can afford more accurate information for diagnosis and prognosis, especially for predicting recurrence and metastasis postoperatively." -tissue_expression_up hsa-mir-155 Rheumatoid Arthritis 24909288 "TPT suppressed the expression of miR-155 and up-regulated the release of SHIP-1, thus inhibiting the inflammatory response in the LPS-stimulated monocytes of RA patients." -tissue_expression_up hsa-mir-224 "Carcinoma, Hepatocellular" 24923856 These results indicate for the first time that miR-224 upregulation and AKT activation may synergistically associate with tumor progression of HCC.The combined high expression of miR-224 and pAKT may be a potential indicator for predicting unfavorable prognosis in HCC patients. -tissue_expression_up hsa-mir-21 "Carcinoma, Breast, Triple Negative" 24930006 High expression of miR-21 in triple-negative breast cancers was correlated with a poor prognosis and promoted tumor cell in vitro proliferation. -tissue_expression_up hsa-mir-326 Multiple Sclerosis 24936144 "For instance, miR-21, miR-142-3p, miR-146a, miR-146b, miR-155 and miR-326 were up-regulated in both peripheral blood mononuclear cells (PBMCs) and brain white matter lesions from MS patients and mouse model as well." -tissue_expression_up hsa-mir-155 Early-Stage Breast Carcinoma 24938880 OncomiRs are significantly more abundant in the sera of EBC patients compared to controls at diagnosis. Differences in oncomiR levels reflecting EBC risk were also observed. Testing the oncomiRs may be useful for diagnostic purpose and possibly also for relapse detection in follow-up studies of EBC. -tissue_expression_up hsa-mir-181b Early-Stage Breast Carcinoma 24938880 OncomiRs are significantly more abundant in the sera of EBC patients compared to controls at diagnosis. Differences in oncomiR levels reflecting EBC risk were also observed. Testing the oncomiRs may be useful for diagnostic purpose and possibly also for relapse detection in follow-up studies of EBC. -tissue_expression_up hsa-mir-19a Early-Stage Breast Carcinoma 24938880 OncomiRs are significantly more abundant in the sera of EBC patients compared to controls at diagnosis. Differences in oncomiR levels reflecting EBC risk were also observed. Testing the oncomiRs may be useful for diagnostic purpose and possibly also for relapse detection in follow-up studies of EBC. -tissue_expression_up hsa-mir-24 Early-Stage Breast Carcinoma 24938880 OncomiRs are significantly more abundant in the sera of EBC patients compared to controls at diagnosis. Differences in oncomiR levels reflecting EBC risk were also observed. Testing the oncomiRs may be useful for diagnostic purpose and possibly also for relapse detection in follow-up studies of EBC. -tissue_expression_up hsa-mir-129 Gastric Neoplasms 24969565 lncRNA-AC130710 targeting by miR-129-5p is upregulated in gastric cancer and associates with poor prognosis. -tissue_expression_up hsa-mir-15a Macular Degeneration 24970617 The expression of several miRNAs related to angiogenesis and fibrosis was expressed significantly higher in the vitreous of eyes with PDR.Further studies are needed to understand the role played by the miRNAs in the biological function of the eye. -tissue_expression_up hsa-mir-29a Macular Degeneration 24970617 The expression of several miRNAs related to angiogenesis and fibrosis was expressed significantly higher in the vitreous of eyes with PDR.Further studies are needed to understand the role played by the miRNAs in the biological function of the eye. -tissue_expression_up hsa-mir-320a Macular Degeneration 24970617 The expression of several miRNAs related to angiogenesis and fibrosis was expressed significantly higher in the vitreous of eyes with PDR.Further studies are needed to understand the role played by the miRNAs in the biological function of the eye. -tissue_expression_up hsa-mir-320b Macular Degeneration 24970617 The expression of several miRNAs related to angiogenesis and fibrosis was expressed significantly higher in the vitreous of eyes with PDR.Further studies are needed to understand the role played by the miRNAs in the biological function of the eye. -tissue_expression_up hsa-mir-423 Macular Degeneration 24970617 The expression of several miRNAs related to angiogenesis and fibrosis was expressed significantly higher in the vitreous of eyes with PDR.Further studies are needed to understand the role played by the miRNAs in the biological function of the eye. -tissue_expression_up hsa-mir-93 Macular Degeneration 24970617 The expression of several miRNAs related to angiogenesis and fibrosis was expressed significantly higher in the vitreous of eyes with PDR.Further studies are needed to understand the role played by the miRNAs in the biological function of the eye. -tissue_expression_up hsa-mir-192 Gastric Neoplasms 24981590 These data suggest that frequently up-regulated miR-215/192 in gastric cancer may participate in gastric cancer progression. -tissue_expression_up hsa-mir-215 Gastric Neoplasms 24981590 These data suggest that frequently up-regulated miR-215/192 in gastric cancer may participate in gastric cancer progression. -tissue_expression_up hsa-mir-302f Breast Neoplasms 24982406 MiR-337 and miR-302f were commonly overexpressed in HER2-postive breast and gastric cancer. MiR-139 and miR-129 were commonly underexpressed in HER2-positive breast and gastric cancer. -tissue_expression_up hsa-mir-155 Colon Neoplasms 24989910 The level of miR-155 was gradually elevated with the formation of colitis-associated colon cancer. -tissue_expression_up hsa-mir-141 Chondrosarcoma 24992595 Paeonol suppresses chondrosarcoma metastasis through up-regulation of miR-141 by modulating PKC¦Ä and c-Src signaling pathway. -tissue_expression_up hsa-mir-143 Chronic Hepatitis 24993656 "In conclusion, the expression of miR-143 and miR-215 in serum were significantly up-regulated in patients with chronic hepatitis and HCC. Due to its reasonable sensitivity and specificity for both diseases, miR-143 and miR-215 could be as potential circulating biomarkers." -tissue_expression_up hsa-mir-215 Chronic Hepatitis 24993656 "In conclusion, the expression of miR-143 and miR-215 in serum were significantly up-regulated in patients with chronic hepatitis and HCC. Due to its reasonable sensitivity and specificity for both diseases, miR-143 and miR-215 could be as potential circulating biomarkers." -tissue_expression_up hsa-mir-126 Asthma 24995087 "Compared to the normal group, miR-21 and miR-126 expression was significantly upregulated in asthma patients regardless of treatment." -tissue_expression_up hsa-mir-141 "Carcinoma, Lung, Non-Small-Cell" 25003366 High miR-141 and miR-200c expression are associated with shorter OS in NSCLC patients with adenocarcinoma through MET and angiogenesis. -tissue_expression_up hsa-mir-200c "Carcinoma, Lung, Non-Small-Cell" 25003366 High miR-141 and miR-200c expression are associated with shorter OS in NSCLC patients with adenocarcinoma through MET and angiogenesis. -tissue_expression_up hsa-mir-758 Hepatitis C Virus Infection 25008898 Hepatitis C virus infection decreases the expression of Toll-like receptors 3 and 7 via upregulation of miR-758. -tissue_expression_up hsa-mir-1288 Ectopic Pregnancy 25013942 "Microarray studies showed that four miRNAs were differentially downregulated (hsa-mir-196b, hsa-mir-30a, hsa-mir-873, and hsa-mir-337-3p) and three upregulated (hsa-mir-1288, hsa-mir-451, and hsa-mir-223) in EP compared to control tissue samples." -tissue_expression_up hsa-mir-223 Ectopic Pregnancy 25013942 "Microarray studies showed that four miRNAs were differentially downregulated (hsa-mir-196b, hsa-mir-30a, hsa-mir-873, and hsa-mir-337-3p) and three upregulated (hsa-mir-1288, hsa-mir-451, and hsa-mir-223) in EP compared to control tissue samples." -tissue_expression_up hsa-mir-451 Ectopic Pregnancy 25013942 "Microarray studies showed that four miRNAs were differentially downregulated (hsa-mir-196b, hsa-mir-30a, hsa-mir-873, and hsa-mir-337-3p) and three upregulated (hsa-mir-1288, hsa-mir-451, and hsa-mir-223) in EP compared to control tissue samples." -tissue_expression_up hsa-mir-210 Preeclampsia 25015807 "This increases the expression of miR-210 in the placenta causing repression of mitochondria-associated target genes, potentially leading to mitochondrial and placental dysfunction." -tissue_expression_up hsa-mir-145 Colorectal Carcinoma 25019299 Up-regulation of microRNA-145 associates with lymph node metastasis in colorectal cancer. -tissue_expression_up hsa-mir-139 Breast Neoplasms 25027758 "Down-regulation of miR-486-5p and miR-139-5p, in conjunction with up-regulation of miR-21, may represent a useful signature for the identification of high-risk breast cancer patients." -tissue_expression_up hsa-mir-21 Breast Neoplasms 25027758 "Down-regulation of miR-486-5p and miR-139-5p, in conjunction with up-regulation of miR-21, may represent a useful signature for the identification of high-risk breast cancer patients." -tissue_expression_up hsa-mir-486 Breast Neoplasms 25027758 "Down-regulation of miR-486-5p and miR-139-5p, in conjunction with up-regulation of miR-21, may represent a useful signature for the identification of high-risk breast cancer patients." -tissue_expression_up hsa-mir-630 Kidney Neoplasms 25031755 "The study proves for the first time that miR-630 is upregulated in a majority of ccRCC patients. It also shows that miR-630 expression is an independent prognostic factor for patients with renal cancer, which might be a potential valuable biomarker for ccRCC." -tissue_expression_up hsa-mir-182 Colorectal Carcinoma 25031782 Increased expression of miRNA-182 in colorectal carcinoma: an independent and tissue-specific prognostic factor. -tissue_expression_up hsa-mir-31 Kawasaki Syndrome 25039241 "These results suggest that the decrease in FoxP3(+) Treg might be associated with decreased expression of miR-155, leading to aberrant SOCS1/STAT-5 signalling and overexpression of miR-31 in patients with acute KD." -tissue_expression_up hsa-mir-106b Medulloblastoma 25041637 These data suggested the upregulation of miR-106b in MB and the involvement of miR-106b in MB biology. -tissue_expression_up hsa-mir-143 Sepsis 25043848 "Through microRNA microarray and qRT-PCR we found that the levels of miR-27a, miR-153 and miR-143 are up regulated, while let-7a, miR-218 and miR-129-5p are down regulated in lungs of septic mice." -tissue_expression_up hsa-mir-34c Alzheimer Disease 25052764 "We have used an in vivo neonatal mouse model to induce ketamine-related neurotoxicity in the hippocampus, and found that miR-34c, a microRNA associated with pathogenesis of Alzheimer's disease, was significantly upregulated during ketamine-induced hippocampal neurodegeneration." -tissue_expression_up hsa-let-7d HIV-Associated Lipodystrophy 25063777 "Eleven other miRNAs (i.e. miR-let-7d, miR-24, miR-30c, miR-125a-3p, miR-149, miR-191, miR-196-b, miR-218, miR-342-3p, miR-452 and miR-454*) were 2- to 2.5-fold more expressed in HIV+ samples than in controls." -tissue_expression_up hsa-mir-125 HIV-Associated Lipodystrophy 25063777 "Eleven other miRNAs (i.e. miR-let-7d, miR-24, miR-30c, miR-125a-3p, miR-149, miR-191, miR-196-b, miR-218, miR-342-3p, miR-452 and miR-454*) were 2- to 2.5-fold more expressed in HIV+ samples than in controls." -tissue_expression_up hsa-mir-125a HIV-Associated Lipodystrophy 25063777 "Eleven other miRNAs (i.e. miR-let-7d, miR-24, miR-30c, miR-125a-3p, miR-149, miR-191, miR-196-b, miR-218, miR-342-3p, miR-452 and miR-454*) were 2- to 2.5-fold more expressed in HIV+ samples than in controls." -tissue_expression_up hsa-mir-149 HIV-Associated Lipodystrophy 25063777 "Eleven other miRNAs (i.e. miR-let-7d, miR-24, miR-30c, miR-125a-3p, miR-149, miR-191, miR-196-b, miR-218, miR-342-3p, miR-452 and miR-454*) were 2- to 2.5-fold more expressed in HIV+ samples than in controls." -tissue_expression_up hsa-mir-186 HIV-Associated Lipodystrophy 25063777 "Ten of these (i.e. miR-186, miR-199a-3p, miR-214, miR-374a, miR-487b, miR-532-5p, miR-628-5p, miR-874, miR-125-b-1* and miR-374b*) were up-regulated to a significant degree" -tissue_expression_up hsa-mir-191 HIV-Associated Lipodystrophy 25063777 "Eleven other miRNAs (i.e. miR-let-7d, miR-24, miR-30c, miR-125a-3p, miR-149, miR-191, miR-196-b, miR-218, miR-342-3p, miR-452 and miR-454*) were 2- to 2.5-fold more expressed in HIV+ samples than in controls." -tissue_expression_up hsa-mir-196b HIV-Associated Lipodystrophy 25063777 "Eleven other miRNAs (i.e. miR-let-7d, miR-24, miR-30c, miR-125a-3p, miR-149, miR-191, miR-196-b, miR-218, miR-342-3p, miR-452 and miR-454*) were 2- to 2.5-fold more expressed in HIV+ samples than in controls." -tissue_expression_up hsa-mir-199a HIV-Associated Lipodystrophy 25063777 "Ten of these (i.e. miR-186, miR-199a-3p, miR-214, miR-374a, miR-487b, miR-532-5p, miR-628-5p, miR-874, miR-125-b-1* and miR-374b*) were up-regulated to a significant degree" -tissue_expression_up hsa-mir-214 HIV-Associated Lipodystrophy 25063777 "Ten of these (i.e. miR-186, miR-199a-3p, miR-214, miR-374a, miR-487b, miR-532-5p, miR-628-5p, miR-874, miR-125-b-1* and miR-374b*) were up-regulated to a significant degree" -tissue_expression_up hsa-mir-218 HIV-Associated Lipodystrophy 25063777 "Eleven other miRNAs (i.e. miR-let-7d, miR-24, miR-30c, miR-125a-3p, miR-149, miR-191, miR-196-b, miR-218, miR-342-3p, miR-452 and miR-454*) were 2- to 2.5-fold more expressed in HIV+ samples than in controls." -tissue_expression_up hsa-mir-24 HIV-Associated Lipodystrophy 25063777 "Eleven other miRNAs (i.e. miR-let-7d, miR-24, miR-30c, miR-125a-3p, miR-149, miR-191, miR-196-b, miR-218, miR-342-3p, miR-452 and miR-454*) were 2- to 2.5-fold more expressed in HIV+ samples than in controls." -tissue_expression_up hsa-mir-30c HIV-Associated Lipodystrophy 25063777 "Eleven other miRNAs (i.e. miR-let-7d, miR-24, miR-30c, miR-125a-3p, miR-149, miR-191, miR-196-b, miR-218, miR-342-3p, miR-452 and miR-454*) were 2- to 2.5-fold more expressed in HIV+ samples than in controls." -tissue_expression_up hsa-mir-342 HIV-Associated Lipodystrophy 25063777 "Eleven other miRNAs (i.e. miR-let-7d, miR-24, miR-30c, miR-125a-3p, miR-149, miR-191, miR-196-b, miR-218, miR-342-3p, miR-452 and miR-454*) were 2- to 2.5-fold more expressed in HIV+ samples than in controls." -tissue_expression_up hsa-mir-374a HIV-Associated Lipodystrophy 25063777 "Ten of these (i.e. miR-186, miR-199a-3p, miR-214, miR-374a, miR-487b, miR-532-5p, miR-628-5p, miR-874, miR-125-b-1* and miR-374b*) were up-regulated to a significant degree" -tissue_expression_up hsa-mir-374b HIV-Associated Lipodystrophy 25063777 "Ten of these (i.e. miR-186, miR-199a-3p, miR-214, miR-374a, miR-487b, miR-532-5p, miR-628-5p, miR-874, miR-125-b-1* and miR-374b*) were up-regulated to a significant degree" -tissue_expression_up hsa-mir-452 HIV-Associated Lipodystrophy 25063777 "Eleven other miRNAs (i.e. miR-let-7d, miR-24, miR-30c, miR-125a-3p, miR-149, miR-191, miR-196-b, miR-218, miR-342-3p, miR-452 and miR-454*) were 2- to 2.5-fold more expressed in HIV+ samples than in controls." -tissue_expression_up hsa-mir-454 HIV-Associated Lipodystrophy 25063777 "Eleven other miRNAs (i.e. miR-let-7d, miR-24, miR-30c, miR-125a-3p, miR-149, miR-191, miR-196-b, miR-218, miR-342-3p, miR-452 and miR-454*) were 2- to 2.5-fold more expressed in HIV+ samples than in controls." -tissue_expression_up hsa-mir-487b HIV-Associated Lipodystrophy 25063777 "Ten of these (i.e. miR-186, miR-199a-3p, miR-214, miR-374a, miR-487b, miR-532-5p, miR-628-5p, miR-874, miR-125-b-1* and miR-374b*) were up-regulated to a significant degree" -tissue_expression_up hsa-mir-532 HIV-Associated Lipodystrophy 25063777 "Ten of these (i.e. miR-186, miR-199a-3p, miR-214, miR-374a, miR-487b, miR-532-5p, miR-628-5p, miR-874, miR-125-b-1* and miR-374b*) were up-regulated to a significant degree" -tissue_expression_up hsa-mir-628 HIV-Associated Lipodystrophy 25063777 "Ten of these (i.e. miR-186, miR-199a-3p, miR-214, miR-374a, miR-487b, miR-532-5p, miR-628-5p, miR-874, miR-125-b-1* and miR-374b*) were up-regulated to a significant degree" -tissue_expression_up hsa-mir-874 HIV-Associated Lipodystrophy 25063777 "Ten of these (i.e. miR-186, miR-199a-3p, miR-214, miR-374a, miR-487b, miR-532-5p, miR-628-5p, miR-874, miR-125-b-1* and miR-374b*) were up-regulated to a significant degree" -tissue_expression_up hsa-mir-92a Myocardial Infarction 25064220 miR-92a expression in ischemia-reperfusion group was significantly higher than in sham operation group -tissue_expression_up hsa-mir-222 Bladder Neoplasms 25078265 Increased expression of miR-222 is associated with poor prognosis in bladder cancer. -tissue_expression_up hsa-mir-190 Epstein-Barr Virus Infection 25086243 mir-190 is upregulated in Epstein-Barr Virus type I latency and modulates cellular mRNAs involved in cell survival and viral reactivation. -tissue_expression_up hsa-mir-145 Malignant Neoplasms [unspecific] 25106061 "Our findings indicate that high miR-145 expression is better at predicting patient survival rather than disease progression for malignant tumors, especially for SCC and glioblastoma in Asians. Considering the insufficient evidence, further investigations and more studies are needed." -tissue_expression_up hsa-mir-19a Bladder Neoplasms 25107371 Our data indicated that miR-19a might act as an oncogenic microRNA in bladder cancer and was significantly up-regulated in bladder cancer carcinogenesis. The oncogenic role of miR19a in bladder cancer was dependent on targeting PTEN. -tissue_expression_up hsa-mir-106a Gastric Neoplasms 25115709 Similarly up-regulated microRNA-106a in matched formalin-fixed paraffin-embedded and fresh frozen samples and the dynamic changes during gastric carcinogenesis and development. -tissue_expression_up hsa-mir-24 Breast Neoplasms 25120807 Over-expression of miR-24 and miR-378 in FFPE tissue of breast cancer patients might conduct as an ideal source for biomarker discovery and validation in breast cancer patients. -tissue_expression_up hsa-mir-378a Breast Neoplasms 25120807 Over-expression of miR-24 and miR-378 in FFPE tissue of breast cancer patients might conduct as an ideal source for biomarker discovery and validation in breast cancer patients. -tissue_expression_up hsa-mir-31 "Carcinoma, Gingival" 25126847 "Expression of hsa-miR-31 was significantly up-regulated in both cancer and leukoplakia tissues and, thus, may be one of the molecular markers of leukoplakia which may progress to gingivo-buccal cancer." -tissue_expression_up hsa-mir-582 Prostate Neoplasms 25176332 Our results suggest that up-regulation of miR-582-5p contributes to an increase in the proliferation of prostate cancer cells under androgen deprived conditions. -tissue_expression_up hsa-mir-146a Diabetic Nephropathy 25182190 "Taken together, these findings indicate that the increased expression of miR-155 and miR-146a in the DN patients and in the experimental DN animal models was found to contribute to inflammation-mediated glomerular endothelial injury." -tissue_expression_up hsa-mir-155 Diabetic Nephropathy 25182190 "Taken together, these findings indicate that the increased expression of miR-155 and miR-146a in the DN patients and in the experimental DN animal models was found to contribute to inflammation-mediated glomerular endothelial injury." -tissue_expression_up hsa-mir-140 Spinal Chordoma 25197358 "Over-expression of miR-140-3p is correlated with recurrence and tumor invasion, suggesting that miR-140-3p could be a new predictor for recurrence and prognosis in patients with spinal chordoma." -tissue_expression_up hsa-mir-185 "Carcinoma, Renal Cell" 25217984 Elevated microRNA-185 is associated with high vascular endothelial growth factor receptor 2 expression levels and high microvessel density in clear cell renal cell carcinoma. -tissue_expression_up hsa-mir-129 Colorectal Carcinoma 25218158 Piceatannol promotes apoptosis via up-regulation of microRNA-129 expression in colorectal cancer cell lines. -tissue_expression_up hsa-mir-132 Glioma 25234714 Upregulation of miR-132 expression in glioma and its clinical significance. -tissue_expression_up hsa-mir-7 Pancreatic Neoplasms 25256401 Curcumin inhibits cell growth and invasion through up-regulation of miR-7 in pancreatic cancer cells. -tissue_expression_up hsa-mir-155 Rectal Neoplasms 25261908 Increase in the expression of miR-155 might represent a potential valuable marker for rectal carcinoma N and combined tumor-node-metastasis staging. -tissue_expression_up hsa-mir-10a Breast Neoplasms 25266482 These findings indicate that higher expression of RUNX2 and miR-10a/b was associated with adverse outcome of breast cancer. Expression levels of RUNX2 and miR-10a/b individually or jointly are potential prognostic factors for predicting breast cancer recurrence. Data from in vitro studies support the notion that RUNX2 promoted cell motility by upregulating miR-10a/b. -tissue_expression_up hsa-mir-10b Breast Neoplasms 25266482 These findings indicate that higher expression of RUNX2 and miR-10a/b was associated with adverse outcome of breast cancer. Expression levels of RUNX2 and miR-10a/b individually or jointly are potential prognostic factors for predicting breast cancer recurrence. Data from in vitro studies support the notion that RUNX2 promoted cell motility by upregulating miR-10a/b. -tissue_expression_up hsa-mir-184 Glioma 25277131 miR-184 upregulation enhanced the malignant phenotype of human glioma cancer cells by reducing FIH-1 protein expression. -tissue_expression_up hsa-mir-141 Bladder Neoplasms 25304156 Increased miR-141 expression is associated with diagnosis and favorable prognosis of patients with bladder cancer. -tissue_expression_up hsa-mir-214 Pancreatic Neoplasms 25304377 "Thirteen miRNAs (miR-138, miR-195, miR-204, miR-216a, miR-217, miR-218, miR-802, miR-155, miR-214, miR-26a, miR-30b, miR-31, and miR-125) were enriched and two miRNAs (miR-451a and miR-4284) were depleted in the cyst fluids derived from invasive carcinomas." -tissue_expression_up hsa-mir-218 Pancreatic Neoplasms 25304377 "Thirteen miRNAs (miR-138, miR-195, miR-204, miR-216a, miR-217, miR-218, miR-802, miR-155, miR-214, miR-26a, miR-30b, miR-31, and miR-125) were enriched and two miRNAs (miR-451a and miR-4284) were depleted in the cyst fluids derived from invasive carcinomas." -tissue_expression_up hsa-mir-30b Pancreatic Neoplasms 25304377 "Thirteen miRNAs (miR-138, miR-195, miR-204, miR-216a, miR-217, miR-218, miR-802, miR-155, miR-214, miR-26a, miR-30b, miR-31, and miR-125) were enriched and two miRNAs (miR-451a and miR-4284) were depleted in the cyst fluids derived from invasive carcinomas." -tissue_expression_up hsa-mir-301a Breast Neoplasms 25311065 Upregulation of miR-301a correlates with poor prognosis in triple-negative breast cancer. -tissue_expression_up hsa-mir-137 Bladder Neoplasms 25330156 MicroRNA-137 upregulation increases bladder cancer cell proliferation and invasion by targeting PAQR3. -tissue_expression_up hsa-mir-21 Breast Neoplasms 25337203 Prognostic and clinicopathological significance of microRNA-21 overexpression in breast cancer: a meta-analysis. -tissue_expression_up hsa-mir-195 Cardiovascular Diseases [unspecific] 25339460 "The cardiac dysfunction of the rat with selenium deficiency was mainly associated with five upregulated miRNAs, which were miR-374, miR-16, miR-199a-5p, miR-195 and miR-30e*, and three downregulated miRNAs, which were miR-3571, miR-675 and miR-450a*." -tissue_expression_up hsa-mir-30d Diabetic Cardiomyopathies 25341033 Our study revealed that mir-30d expression was substantially increased in streptozotocin (STZ)-induced diabetic rats and in high-glucose-treated cardiomyocytes as well. -tissue_expression_up hsa-mir-128a "Carcinoma, Hepatocellular" 25345933 miR-128a is up-regulated in HCC and promotes HCC cell proliferation by targeting RND3. -tissue_expression_up hsa-mir-31 Pleural Mesothelioma 25358615 Upregulation of microRNA-31 associates with a poor prognosis of malignant pleural mesothelioma with sarcomatoid component. -tissue_expression_up hsa-mir-200a Ovarian Neoplasms 25374174 miR-200a overexpression in advanced ovarian carcinomas as a prognostic indicator. -tissue_expression_up hsa-mir-196a Gastric Neoplasms 25374225 Association of miR-193b down-regulation and miR-196a up-regulation with clinicopathological features andprognosis in gastric cancer. -tissue_expression_up hsa-mir-210 "Carcinoma, Lung, Non-Small-Cell" 25384507 "At the same time, miR-21 and miR-210 were upregulated by 53.3 and 66.6% in cancer tissue versus matched adjacent normal tissues, respectively." -tissue_expression_up hsa-mir-141 Endometriosis 25386850 "We found five miRNAs specific to epithelial cells--miR-34c, miR-449a, miR-200a, miR-200b and miR-141 showing significantly higher expression in peritoneal endometriotic lesions compared to healthy peritoneal tissues." -tissue_expression_up hsa-mir-200b Endometriosis 25386850 "We found five miRNAs specific to epithelial cells--miR-34c, miR-449a, miR-200a, miR-200b and miR-141 showing significantly higher expression in peritoneal endometriotic lesions compared to healthy peritoneal tissues." -tissue_expression_up hsa-mir-143 Endometriosis 25408705 miR-143 was up-regulated in EC (p=0.000) compared to EN. -tissue_expression_up hsa-mir-145 Endometriosis 25408705 The miR-145 was up-regulated in both EU (p=0.004) and EC (p=0.000) in compared to EN group. -tissue_expression_up hsa-mir-194 Gastric Neoplasms 25412959 "miR-194 overexpression or RBX1 lowexpression was associated with prolonged survival of GC patients. In conclusion, upregulation of miR-194 can inhibit proliferation, migration, and invasion of GC cells, possibly by targeting RBX1. Aberrant expression of miR-194 and RBX1 is correlated to GC patient survival time." -tissue_expression_up hsa-mir-18a Gastric Neoplasms 25416437 "miR-18a may be a promising biomarker for the detection of gastric cancer and its upregulation may be potentially associated with unfavorable prognosis of bladder cancer, suggesting that miR-18a might serve as a potential biological marker for further risk stratification in the management of gastric cancer." -tissue_expression_up hsa-mir-224 Colorectal Adenocarcinoma 25420464 "miR-224 is significantly upregulated in malignant colorectal tumors compared to adjacent non-cancer mucosae, and its enhanced expression constitutes an independent predictor of short-term relapse and poor overall survival in colorectal adenocarcinoma patients." -tissue_expression_up hsa-mir-221 Glioma 25428536 "There are a series of abnormal miRNA expressions in glioma. Among them, miR-221 and miR -222 are clustered miR s with elevated expressions. The over-expressions of miR-221 and miR-222 can be considered as new molecular tags for human glioma (Tab. 5, Fig. 4, Ref. 30)." -tissue_expression_up hsa-mir-222 Glioma 25428536 "There are a series of abnormal miRNA expressions in glioma. Among them, miR-221 and miR -222 are clustered miR s with elevated expressions. The over-expressions of miR-221 and miR-222 can be considered as new molecular tags for human glioma (Tab. 5, Fig. 4, Ref. 30)." -tissue_expression_up hsa-mir-21 Breast Neoplasms 25440114 "the context of altered miR-21 expression provides clinically relevant information. Importantly, miR-21 expression was predominantly up-regulated and potentially prognostic in the tumor stroma of TNBC." -tissue_expression_up hsa-mir-145 Aortic Aneurysm 25465469 The increased expression of microRNA-145 promotes media remodeling through TGF-b1 in the aortic aneurysm wall. -tissue_expression_up hsa-mir-106b "Carcinoma, Hepatocellular" 25466449 miR-106b expression was significantly upregulated in HCC and could serve as a potential unfavorable prognostic biomarker. -tissue_expression_up hsa-mir-21 "Squamous Cell Carcinoma, Oral" 25482863 "Our results corroborate the previous findings on the overexpression of mir-21 and downregulation of miR-138 in OSCC. As the expression of miR-184 is controversial in tongue/oral cancer, the downregulation may be specific to tumor anatomical localization. On the other hand, to the best of our knowledge, this is the first report to show the association of miR-155 with tobacco chewing and the downregulation of miR-125b-2* in OSCC. Computational predictions suggest that miR-125b-2* may have a role in alternative splicing." -tissue_expression_up hsa-mir-146a Diabetes Mellitus 25490205 abnormal miR-146a upregulation may be an important mechanism of delayed wound healing in the diabetic cornea. -tissue_expression_up hsa-mir-125b Glioma 25502291 "Higher expressions of miR-125b and miR-222 have also been proved to be associated with glioma. Furthermore, glioma patients with higher miR-125b, miR-221, and miR-222 expression were manifested to have poorer prognostic status, which might be attributed to their attenuated sensitivity to chemotherapy and radiotherapy." -tissue_expression_up hsa-mir-221 Glioma 25502291 "Higher expressions of miR-125b and miR-222 have also been proved to be associated with glioma. Furthermore, glioma patients with higher miR-125b, miR-221, and miR-222 expression were manifested to have poorer prognostic status, which might be attributed to their attenuated sensitivity to chemotherapy and radiotherapy." -tissue_expression_up hsa-mir-222 Glioma 25502291 "Higher expressions of miR-125b and miR-222 have also been proved to be associated with glioma. Furthermore, glioma patients with higher miR-125b, miR-221, and miR-222 expression were manifested to have poorer prognostic status, which might be attributed to their attenuated sensitivity to chemotherapy and radiotherapy." -tissue_expression_up hsa-mir-10b Neoplasms [unspecific] 25510966 high-expression of microRNA-10b can predict worse outcomes in some types of cancer and the regular monitoring of miR-10b expression might be useful in the clinical practice. -tissue_expression_up hsa-mir-374b Gastric Neoplasms 25516656 upregulation of miR-374b-5p contributes to gastric cancer cell metastasis and invasion through inhibition of RECK expression. -tissue_expression_up hsa-mir-146a "Carcinoma, Thyroid" 25524940 Up-regulation of miR-146a and miR-146b expression in tissues was related to carcinogenesis and deterioration of PTC. MicroRNA-146a and miR-146b expressed in thyroid tissue may act as potential biomarkers for PTC patients. -tissue_expression_up hsa-mir-146b "Carcinoma, Thyroid" 25524940 Up-regulation of miR-146a and miR-146b expression in tissues was related to carcinogenesis and deterioration of PTC. MicroRNA-146a and miR-146b expressed in thyroid tissue may act as potential biomarkers for PTC patients. -tissue_expression_up hsa-mir-143 Osteosarcoma 25562163 "TGF-¦Â1 up-regulates versican expression bysuppressing miR-143, and this pathway is important for osteosarcoma cell migration and invasion." -tissue_expression_up hsa-mir-21 "Carcinoma, Colon" 25569638 the primary tumor in colon cancer releases high concentrations of miR-21 in the MV but that these concentrations are later diluted in the circulatory system. MV expression of miR-21 may be a stronger prognostic marker than PV expression. -tissue_expression_up hsa-mir-210 Glioblastoma 25586423 Acute hypoxia induces upregulation of microRNA-210 expression in glioblastoma spheroids. -tissue_expression_up hsa-mir-142 Atherosclerosis 25586666 the upregulation of miR-142-5p expression may regulate apoptosis in human macrophages by targeting TGF-¦Â2. This effect may have an important role in the progression of atherosclerosis. -tissue_expression_up hsa-mir-196a Osteosarcoma 25599934 the effects of miR-196a over-expression on tumour cell response may be strictly related to species and cell type. Further studies are needed to define the impact of miRNA deregulation on OS development. -tissue_expression_up hsa-mir-155 Lung Neoplasms 25603615 The current paper on Meta-analysis demonstrated a correlation between the high expression of miRNA-155 and the outcome of patients with non-small cell lung cancer. -tissue_expression_up hsa-mir-125b Breast Neoplasms 25605244 up-regulation of miR-125b or targeting Sema4C could serve as novel approaches to reverse chemotherapy resistance in breast cancers. -tissue_expression_up hsa-mir-34a Osteonecrosis 25612520 The expression of miR-34a and miR-146a and genes in the predict pathways were significantly up-regulated. -tissue_expression_up hsa-mir-132 "Leukemia, Lymphocytic, Chronic, B-Cell" 25645730 Increased chronic lymphocytic leukemia proliferation upon IgM stimulation is sustained by the upregulation of miR-132 and miR-212. -tissue_expression_up hsa-mir-212 "Leukemia, Lymphocytic, Chronic, B-Cell" 25645730 Increased chronic lymphocytic leukemia proliferation upon IgM stimulation is sustained by the upregulation of miR-132 and miR-212. -tissue_expression_up hsa-mir-92a Colorectal Adenocarcinoma 25663865 A statistically significant difference was observed between the expression levels of miR-92a in CA and the paralesional normal controls. -tissue_expression_up hsa-mir-199 Irritable Bowel Syndrome 25681400 Decreased miR-199 augments visceral pain in patients with IBS through translational upregulation of TRPV1. -tissue_expression_up hsa-mir-21 Ischemia-Reperfusion Injury 25691473 miR-21 has been shown to be enriched in kidney tissue in mice and humans with acute kidney injury -tissue_expression_up hsa-mir-218 Gastric Neoplasms 25694126 Thermo-chemotherapy Induced miR-218 upregulation inhibits the invasion of gastric cancer via targeting Gli2 and E-cadherin. -tissue_expression_up hsa-mir-1280 "Carcinoma, Lung, Non-Small-Cell" 25698202 The miR-1280 expression was significantly higher in the NSCLC tissues than distal normal tissues -tissue_expression_up hsa-mir-141 Bladder Neoplasms 25703910 "There was a more expression rate of miR-200c, miR-141 and miR-30b in bladder cancer tissues than healthy adjacent control tissues. Further studies are needed to draw final conclusion." -tissue_expression_up hsa-mir-200c Bladder Neoplasms 25703910 "There was a more expression rate of miR-200c, miR-141 and miR-30b in bladder cancer tissues than healthy adjacent control tissues. Further studies are needed to draw final conclusion." -tissue_expression_up hsa-mir-30b Bladder Neoplasms 25703910 "There was a more expression rate of miR-200c, miR-141 and miR-30b in bladder cancer tissues than healthy adjacent control tissues. Further studies are needed to draw final conclusion." -tissue_expression_up hsa-mir-21 Multiple Myeloma 25704079 EBV could further exacerbate the disease by inducing miR-21 -tissue_expression_up hsa-mir-146b Atherosclerosis 25743474 Aa challenge significantly increased the expression of miR-146b and miR-155 in the aorta. -tissue_expression_up hsa-mir-181b Adenovirus Infection 25744056 The expression patterns of these miRNAs changed dramatically during the course of the infection -tissue_expression_up hsa-mir-191 Adenovirus Infection 25744056 The expression patterns of these miRNAs changed dramatically during the course of the infection -tissue_expression_up hsa-mir-21 "Adenocarcinoma, Esophageal" 25746664 "miRs such as miR-192, miR-196 and miR-21 were frequently noted to up-regulated whereas miR-203, miR-205 and miR-let-7 were commonly down-regulated during the development of Barrett's oesophagus to oesophageal adenocarcinoma." -tissue_expression_up hsa-mir-503 "Carcinoma, Esophageal" 25750296 High miR-503 expression was identified as an independent prognostic predictor in patients with EC according to multivariate analysis -tissue_expression_up hsa-mir-146b Gastroduodenal Ulcer 25753878 "This study indicated that the up-regulation of miR-155 and miR-146b decreases H. pylori (cagA+)-introduced IL6 overexpression, which might weaken the cleanup of H. pylori (cagA+) and contributes to ulcer." -tissue_expression_up hsa-mir-155 Gastroduodenal Ulcer 25753878 "This study indicated that the up-regulation of miR-155 and miR-146b decreases H. pylori (cagA+)-introduced IL6 overexpression, which might weaken the cleanup of H. pylori (cagA+) and contributes to ulcer." -tissue_expression_up hsa-mir-150 "Carcinoma, Lung, Non-Small-Cell" 25755784 Our data indicated that overexpression of miR-150 in NSCLC tissues has prognostic value. -tissue_expression_up hsa-mir-10b Glioma 25773393 Correlation of microRNA-10b upregulation and poor prognosis in human gliomas. -tissue_expression_up hsa-mir-1246 "Squamous Cell Carcinoma, Oral" 25791131 High miR-1246 expression is associated with poor prognosis in OSCC and may serve as a novel prognostic marker in OSCC. -tissue_expression_up hsa-mir-125b Mesial Temporal Lobe Epilepsy 25801837 "In TLE patients, miR-183, miR- 135a, miR-125b, miR-30c and miR-27a were upregulated, whereas miR-128 was downregulated." -tissue_expression_up hsa-mir-183 Mesial Temporal Lobe Epilepsy 25801837 "In TLE patients, miR-183, miR- 135a, miR-125b, miR-30c and miR-27a were upregulated, whereas miR-128 was downregulated." -tissue_expression_up hsa-mir-24 Hyperglycemia 25814526 Hyperglycemia repression of miR-24 coordinately upregulates endothelial cell expression and secretion of von Willebrand factor. -tissue_expression_up hsa-let-7g Follicular Atresia 25824548 let-7g was highly expressed during follicle atresia -tissue_expression_up hsa-mir-200c "Carcinoma, Renal Cell" 25860934 Loss of miR-200c up-regulates CYP1B1 and confers docetaxel resistance in renal cell carcinoma. -tissue_expression_up hsa-let-7a "Squamous Cell Carcinoma, Head and Neck" 25862914 The microRNA profile seems to play a potential role in the pathobiology of oropharyngeal and laryngeal HNSCC. Up-regulation of miR34a in p16-positive oropharyngeal cancer has not been so far described and additional studies are warranted. -tissue_expression_up hsa-mir-200c "Squamous Cell Carcinoma, Head and Neck" 25862914 The microRNA profile seems to play a potential role in the pathobiology of oropharyngeal and laryngeal HNSCC. Up-regulation of miR34a in p16-positive oropharyngeal cancer has not been so far described and additional studies are warranted. -tissue_expression_up hsa-mir-21 "Squamous Cell Carcinoma, Head and Neck" 25862914 The microRNA profile seems to play a potential role in the pathobiology of oropharyngeal and laryngeal HNSCC. Up-regulation of miR34a in p16-positive oropharyngeal cancer has not been so far described and additional studies are warranted. -tissue_expression_up hsa-mir-34a "Squamous Cell Carcinoma, Head and Neck" 25862914 The microRNA profile seems to play a potential role in the pathobiology of oropharyngeal and laryngeal HNSCC. Up-regulation of miR34a in p16-positive oropharyngeal cancer has not been so far described and additional studies are warranted. -tissue_expression_up hsa-mir-375 "Squamous Cell Carcinoma, Head and Neck" 25862914 The microRNA profile seems to play a potential role in the pathobiology of oropharyngeal and laryngeal HNSCC. Up-regulation of miR34a in p16-positive oropharyngeal cancer has not been so far described and additional studies are warranted. -tissue_expression_up hsa-mir-125a Autoimmune Thyroiditis 25863684 Decreased expression of microRNA-125a-3p upregulates interleukin-23 receptor in patients with Hashimoto's thyroiditis. -tissue_expression_up hsa-mir-155 Atherosclerosis 25872580 "our data demonstrate that miR-155 is significantly upregulated in atherosclerotic plaque, functioning to accelerate the proliferation and migration of VSMCs by targeting eNOS." -tissue_expression_up hsa-mir-375 Diabetes Mellitus 25875172 "These findings support an important role of miR-375 in regulation of human ¦Â-cell phenotype, and suggest that miR-375 upregulation may facilitate the generation of functional insulin-producing cells following ex-vivo expansion of human islet cells." -tissue_expression_up hsa-mir-155 Waldenstrom Macroglobulinemia 25893290 "In two cell lines, miR-155 upregulation, which is common in WM, was responsible for the inhibition of FOXO3a and Bim expression." -tissue_expression_up hsa-mir-20b "Carcinoma, Breast" 25893380 miR-20b is up-regulated in brain metastases from primary breast cancers. -tissue_expression_up hsa-mir-10b Endometriosis 25896413 miR-10b directly targets ZEB1 and PIK3CA to curb adenomyotic epithelial cell invasiveness via upregulation of E-Cadherin and inhibition of Akt phosphorylation. -tissue_expression_up hsa-mir-21 Myocardial Infarction 25896982 "Compared to sham group, we found a twofold increase in the cardiac expression of microRNA-21 and 0.5-fold decrease in microRNA-29b in heart tissue from vehicle-treated MI." -tissue_expression_up hsa-mir-9 Osteoarthritis 25917063 These findings implicate miR-9-mediated suppression of MCPIP-1 in the pathogenesis of OA via up-regulation of IL-6 expression in IL-1¦Â-stimulated human OA chondrocytes. -tissue_expression_up hsa-mir-122 Human Immunodeficiency Virus Infection 25920531 "our results revealed that the Vpr-upregulated expression of miR-122 is closely related to the stimulation of HCV 5' UTR activity and HCV replication by Vpr, providing new evidence for how HIV interacts with HCV during HIV/HCV co-infection." -tissue_expression_up hsa-mir-221 Inflammation 25926893 "Interestingly, miR-221 (2-fold, Pâ€?â€?.002), miR-222 (2.5-fold, Pâ€?â€?.04), and miR-155 (5-fold, Pâ€?â€?.015) were increased in inflamed adipocytes" -tissue_expression_up hsa-mir-222 Inflammation 25926893 "Interestingly, miR-221 (2-fold, Pâ€?â€?.002), miR-222 (2.5-fold, Pâ€?â€?.04), and miR-155 (5-fold, Pâ€?â€?.015) were increased in inflamed adipocytes" -tissue_expression_up hsa-mir-15a Cataract 25932180 "hsa-miR-15a-5p, hsa-miR-15a-3p, and hsa-miR-16-1-5p were expressed at low levels in normal lens epithelial cells but at significantly higher levels in corresponding cells of patients" -tissue_expression_up hsa-mir-221 Colon Neoplasms 25932237 "high expression of miR-211 (HR=2.394, 95% CI: 1.210-4.910, P=0.006) were identified as risk factors for colon cancer prognosis" -tissue_expression_up hsa-mir-155 Prostate Neoplasms 25938433 "hsa-miR-155, hsa-miR-141 and hsa-miR-21 gene expressions were significantly elevated (66-85%, P<0.05) in tumor specimens" -tissue_expression_up hsa-mir-328 "Leukemia, Myeloid, Chronic" 25948184 "miR-328 has been successfully constructed and transfected into K562 cells, miR-328 inhibits the proliferation of K562 cells by up-regulation of C/EBP¦Á." -tissue_expression_up hsa-mir-21 "Adenocarcinoma, Esophageal" 25950983 microRNA-21 expression is elevated in esophageal adenocarcinoma after neoadjuvant chemotherapy. -tissue_expression_up hsa-mir-182 Prostate Neoplasms 25977730 MicroRNA expression profiling in primary PCa and morphological normal prostate (MNPT) tissues identified 17 miRNAs significantly overexpressed in PCa. -tissue_expression_up hsa-mir-15a Asthma 25979194 miRNA regulation network demonstrated that miR-16 and miR-15a had higher degree. -tissue_expression_up hsa-mir-16 Asthma 25979194 miRNA regulation network demonstrated that miR-16 and miR-15a had higher degree. -tissue_expression_up hsa-mir-34a Melanoma 25982144 Real-time PCR analysis showed 14-fold increase of miR-34a expression in the SDT group compared to the control group -tissue_expression_up hsa-mir-141 Colorectal Carcinoma 25989926 "A set of three specific fecal miRNAs is overexpressed before surgery, and return within the normal range after cancer removal could be considered as an appealing opportunity for a new reliable tool for CRC secondary prevention. However, their role needs to be explored in large prospective trials and compared with the existing screening tools." -tissue_expression_up hsa-mir-16 Colorectal Carcinoma 25989926 "A set of three specific fecal miRNAs is overexpressed before surgery, and return within the normal range after cancer removal could be considered as an appealing opportunity for a new reliable tool for CRC secondary prevention. However, their role needs to be explored in large prospective trials and compared with the existing screening tools." -tissue_expression_up hsa-mir-19b Colorectal Carcinoma 25989926 "A set of three specific fecal miRNAs is overexpressed before surgery, and return within the normal range after cancer removal could be considered as an appealing opportunity for a new reliable tool for CRC secondary prevention. However, their role needs to be explored in large prospective trials and compared with the existing screening tools." -tissue_expression_up hsa-mir-20a Colorectal Carcinoma 25989926 "A set of three specific fecal miRNAs is overexpressed before surgery, and return within the normal range after cancer removal could be considered as an appealing opportunity for a new reliable tool for CRC secondary prevention. However, their role needs to be explored in large prospective trials and compared with the existing screening tools." -tissue_expression_up hsa-mir-21 Colorectal Carcinoma 25989926 "A set of three specific fecal miRNAs is overexpressed before surgery, and return within the normal range after cancer removal could be considered as an appealing opportunity for a new reliable tool for CRC secondary prevention. However, their role needs to be explored in large prospective trials and compared with the existing screening tools." -tissue_expression_up hsa-mir-92a Colorectal Carcinoma 25989926 "A set of three specific fecal miRNAs is overexpressed before surgery, and return within the normal range after cancer removal could be considered as an appealing opportunity for a new reliable tool for CRC secondary prevention. However, their role needs to be explored in large prospective trials and compared with the existing screening tools." -tissue_expression_up hsa-mir-141 Bladder Neoplasms 25991007 The present meta-analysis identified eight highly significant and consistently dysregulated miRNAs from 19 datasets. We also constructed an eight-miRNA signature which provided predictive and prognostic value that complements traditional clinicopathological risk factors. -tissue_expression_up hsa-mir-200c Bladder Neoplasms 25991007 The present meta-analysis identified eight highly significant and consistently dysregulated miRNAs from 19 datasets. We also constructed an eight-miRNA signature which provided predictive and prognostic value that complements traditional clinicopathological risk factors. -tissue_expression_up hsa-mir-21 Bladder Neoplasms 25991007 The present meta-analysis identified eight highly significant and consistently dysregulated miRNAs from 19 datasets. We also constructed an eight-miRNA signature which provided predictive and prognostic value that complements traditional clinicopathological risk factors. -tissue_expression_up hsa-mir-146a "Carcinoma, Thyroid, Papillary" 26003825 "Our results demonstrate that down-regulation of THR¦Â is a common feature of PTCs. While it is not associated with a more aggressive phenotype of PTC, it correlates with the reduction of all the markers of differentiation and is associated with overexpression of some miRNAs supposed to play a role in thyroid tumorigenesis." -tissue_expression_up hsa-mir-21 "Carcinoma, Thyroid, Papillary" 26003825 "Our results demonstrate that down-regulation of THR¦Â is a common feature of PTCs. While it is not associated with a more aggressive phenotype of PTC, it correlates with the reduction of all the markers of differentiation and is associated with overexpression of some miRNAs supposed to play a role in thyroid tumorigenesis." -tissue_expression_up hsa-mir-221 "Carcinoma, Thyroid, Papillary" 26003825 "Our results demonstrate that down-regulation of THR¦Â is a common feature of PTCs. While it is not associated with a more aggressive phenotype of PTC, it correlates with the reduction of all the markers of differentiation and is associated with overexpression of some miRNAs supposed to play a role in thyroid tumorigenesis." -tissue_expression_up hsa-mir-21 Neoplasms [unspecific] 26032086 "miR-21, miR-148a, miR-505, and miR-1207-5p were found to be upregulated in growth factors-induced EMT process" -tissue_expression_up hsa-mir-132 "Leukemia, Lymphocytic, Chronic, B-Cell" 26036258 The SIRT1/TP53 axis is activated upon B-cell receptor triggering via miR-132 up-regulation in chronic lymphocytic leukemia cells. -tissue_expression_up hsa-mir-32 Lung Neoplasms 26036635 Tanshinones suppress AURKA through up-regulation of miR-32 expression in non-small cell lung cancer. -tissue_expression_up hsa-mir-141 "Carcinoma, Endometrial" 26045795 miR-200a/miR-141 and miR-205 upregulation might be associated with hormone receptor status and prognosis in endometrial carcinomas. -tissue_expression_up hsa-mir-200a "Carcinoma, Endometrial" 26045795 miR-200a/miR-141 and miR-205 upregulation might be associated with hormone receptor status and prognosis in endometrial carcinomas. -tissue_expression_up hsa-mir-205 "Carcinoma, Endometrial" 26045795 miR-200a/miR-141 and miR-205 upregulation might be associated with hormone receptor status and prognosis in endometrial carcinomas. -tissue_expression_up hsa-mir-1 Acute Myocardial Infarction 26046358 "This study highlights the stability of miRNAs after death and long-term fixation, validating their use as reliable biomarkers for AMI during postmortem examination." -tissue_expression_up hsa-mir-208b Acute Myocardial Infarction 26046358 "This study highlights the stability of miRNAs after death and long-term fixation, validating their use as reliable biomarkers for AMI during postmortem examination." -tissue_expression_up hsa-mir-196a Breast Neoplasms 26062455 MicroRNA-196a post-transcriptionally upregulates the UBE2C proto-oncogene and promotes cell proliferation in breast cancer. -tissue_expression_up hsa-mir-182 Neoplasms [unspecific] 26063957 "High miR-182 expression is associated with poor OS and DFS/RFS/RFI in some types of cancers, and miR-182 may be a useful prognostic biomarker for predicting cancer prognosis. However, given the current insufficient relevant data, further clinical studies are needed." -tissue_expression_up hsa-mir-197 Glioblastoma 26081814 FUS1 acts as a tumor-suppressor gene by upregulating miR-197 in human glioblastoma. -tissue_expression_up hsa-mir-21 Myocardial Ischemic-Reperfusion Injury 26097555 "this study revealed the mechanism that TMZ up-regulated miR-21 expression, then miR-21 targeted PTEN increasing the PI3K pathway and finally the activation of this pathway counteracted the apoptotic effect of hypoxia/reperfusion." -tissue_expression_up hsa-mir-124 "Carcinoma, Gastric" 26109806 Paeoniflorin inhibits human gastric carcinoma cell proliferation through up-regulation of microRNA-124 and suppression of PI3K/Akt and STAT3 signaling. -tissue_expression_up hsa-mir-146b Myeloproliferative Neoplasms 26116595 Up-regulation of MicroRNA 146b is Associated with Myelofibrosis in Myeloproliferative Neoplasms. -tissue_expression_up hsa-mir-218 Glioma 26133092 Propofol suppresses proliferation and invasion of glioma cells by upregulating microRNA-218 expression. -tissue_expression_up hsa-mir-190b Breast Neoplasms 26141719 "This study reveals miR-190b as the highest up-regulated miRNA in hormone-dependent breast cancers. Due to its specificity and high expression level, miR-190b could therefore represent a new biomarker in hormone-dependent breast cancers but its exact role carcinogenesis remains to elucidate." -tissue_expression_up hsa-mir-211 Colorectal Carcinoma 26152286 MicroRNA 211 expression is upregulated and associated with poor prognosis in colorectal cancer: a case-control study. -tissue_expression_up hsa-mir-372 "Carcinoma, Oral" 26152520 Upregulation of miR-372 and -373 associates with lymph node metastasis and poor prognosis of oral carcinomas. -tissue_expression_up hsa-mir-373 "Carcinoma, Oral" 26152520 Upregulation of miR-372 and -373 associates with lymph node metastasis and poor prognosis of oral carcinomas. -tissue_expression_up hsa-mir-126 Heart Failure 26162916 "RV failure in PAH is associated with a specific molecular signature within the RV, contributing to a decrease in RV vascular density and promoting the progression to RV failure. More importantly, miR-126 upregulation in the RV improves microvessel density and RV function in experimental PAH." -tissue_expression_up hsa-mir-183 "Adenocarcinoma, Lung" 26170125 down-regulation of miR-34c and up-regulation of miR-183 and miR-210 were identified in caner groups -tissue_expression_up hsa-mir-210 "Adenocarcinoma, Lung" 26170125 down-regulation of miR-34c and up-regulation of miR-183 and miR-210 were identified in caner groups -tissue_expression_up hsa-mir-34 Neoplasms [unspecific] 26177460 miR-34a overexpression leads to variable effects on p53 levels in p53-sufficient human cancer cell lines. -tissue_expression_up hsa-mir-34a Neoplasms [unspecific] 26177460 miR-34a overexpression leads to variable effects on p53 levels in p53-sufficient human cancer cell lines. -tissue_expression_up hsa-mir-21 Ischemia-Reperfusion Injury 26178499 Renal expressions of miR-21 and miR-106a were significantly elevated in ischemia 20 min and 30 min groups at 12 h and 24 h post-reperfusion -tissue_expression_up hsa-mir-21 Coronary Artery Disease 26183619 miR-21 expression was increased in human tissue samples from patients with ISR compared with coronary artery disease specimen -tissue_expression_up hsa-mir-15b Glioma 26191187 Up-regulation of microRNA-15b correlates with unfavorable prognosis and malignant progression of human glioma. -tissue_expression_up hsa-mir-184 Lung Neoplasms 26199015 miRNA-197 and miRNA-184 are overexpressed in EGFR-mutant patients with BM and they might be a new biomarker for stratifying the risk of BM in this subpopulation. -tissue_expression_up hsa-mir-1298 Vascular Disease [unspecific] 26199195 Keep calm and carry on: miR-1298 prevents up-regulation of Cx43 and secures a quiescent vascular smooth muscle cell. -tissue_expression_up hsa-mir-184 Sebaceous Carcinoma 26203913 "Serial testing and validation confirmed overexpression of 2 miRNAs previously reported to be oncogenic, miR-486-5p (4.4-fold; Pâ€?â€?.4 ×â€?0-8) and miR-184 (3.5-fold; Pâ€?â€?.7 ×â€?0-6)" -tissue_expression_up hsa-mir-21 Gastric Neoplasms 26209976 "It seems that miR-21 and miR-221 expression pattern in Iranian patients with gastric cancer are similar to any other population. Considering the increased expression level of two miRNAs in cancerous tissue compared to normal tissue as well as the area under ROC curve, miR-21 and miR-221 can be used for early detection of gastric cancer." -tissue_expression_up hsa-mir-221 Gastric Neoplasms 26209976 "It seems that miR-21 and miR-221 expression pattern in Iranian patients with gastric cancer are similar to any other population. Considering the increased expression level of two miRNAs in cancerous tissue compared to normal tissue as well as the area under ROC curve, miR-21 and miR-221 can be used for early detection of gastric cancer." -tissue_expression_up hsa-mir-206 Preeclampsia 26213997 Our pilot study has identified miRNA-206 as a novel factor upregulated in preeclampsia within the maternal circulation and in placental tissue. -tissue_expression_up hsa-mir-133a Pancreatic Neoplasms 26214431 Propofol suppresses proliferation and invasion of pancreatic cancer cells by upregulating microRNA-133a expression. -tissue_expression_up hsa-mir-17 "Leukemia-Lymphoma, Adult T-Cell" 26231295 Upregulation of miRNA-17 and miRNA-19 is associated with unfavorable prognosis in patients with T-cell lymphoblastic lymphoma. -tissue_expression_up hsa-mir-19 "Leukemia-Lymphoma, Adult T-Cell" 26231295 Upregulation of miRNA-17 and miRNA-19 is associated with unfavorable prognosis in patients with T-cell lymphoblastic lymphoma. -tissue_expression_up hsa-mir-210 Neoplasms [unspecific] 26239498 MicroRNA-210 is upregulated by hypoxia-inducible factor-1¦Á in the stromal cells of giant cell tumors of bone. -tissue_expression_up hsa-mir-130b Glioblastoma 26241672 Upregulation of miR-130b enhances stem cell-like phenotype in glioblastoma by inactivating the Hippo signaling pathway. -tissue_expression_up hsa-mir-21 Myocardial Infarction 26253453 "Compared with the CON group, miR-1 was downregulated, whereas miR-21 was upregulated, and BCL2 messenger RNA (mRNA) was upregulated, whereas BAX mRNA and programmed cell death 4 mRNA remained unchanged in the IPO group." -tissue_expression_up hsa-let-7b Obesity 26258540 "Specifically, miR-28, miR-26, and let-7b previously shown to inhibit sex steroid production in human granulosa cells, were up-regulated." -tissue_expression_up hsa-mir-221 "Carcinoma, Hepatocellular" 26258795 MiR-221 and miR-222 (miR-221/222) are well-studied oncogenic microRNAs that are frequently upregulated in several types of human tumors -tissue_expression_up hsa-mir-221 Choriocarcinoma 26258795 MiR-221 and miR-222 (miR-221/222) are well-studied oncogenic microRNAs that are frequently upregulated in several types of human tumors -tissue_expression_up hsa-mir-196a Glioma 26261539 Our results suggested that both high-miR-196a and low-miR-367 expression may be associated with aggressive progression and unfavorable clinical outcome in glioma patients. And combination of high-miR-196a and low-miR-367 expression may be a novel biomarker in identifying a poor prognosis group of high-grade glioma. -tissue_expression_up hsa-mir-155 Colorectal Carcinoma 26261588 "miR-155-5p expression is up-regulated in most CRC and promotes proliferation, invasion and metastasis of CRC cells. It may play an essential role in tumorigenesis and tumor progression of CRC." -tissue_expression_up hsa-mir-21 "Carcinoma, Cervical" 26261606 "MiR-21 upregulation is associated with aggressive progression and poor prognosis in cervical cancer, which suggests that miR-21 might be identified as an independent marker for predicting the clinical outcome of cervical cancer patients." -tissue_expression_up hsa-mir-21 "Carcinoma, Hepatocellular" 26261620 Our results suggested that increased expression of miR-21 was significantly correlated with tumor progression and could be a novel potential biomarker for HCC prognosis. -tissue_expression_up hsa-mir-122 Hepatitis C Virus Infection 26272127 The levels of miR-122 were higher in liver than those in blood from individuals infected with HCV genotypes 1 and 3 -tissue_expression_up hsa-mir-125b "Fatty Liver, Non-Alcoholic" 26272872 Our findings identify a novel mechanism by which estrogen protects against hepatic steatosis in female mice via upregulating miR-125b expression. -tissue_expression_up hsa-mir-20a "Carcinoma, Adenoid Cystic" 26293217 Increased expression of miR-17 and miR-20a was found in bACCs compared with bNs -tissue_expression_up hsa-mir-146a Systemic Lupus Erythematosus 26315540 "Type I IFN inhibits the maturation of miR-146a through the up-regulation of MCPIP-1, and thus contributes to the uncontrolled inflammation and excessive inflammatory gene expression in SLE." -tissue_expression_up hsa-mir-146b Atrial Fibrillation 26319023 "Expression of inflammation-associated miRNAs is significantly up-regulated in the left atrial appendage of patients with non-valvular paroxysmal atrial fibrillation, which may play a significant role in electrical and structural remodeling." -tissue_expression_up hsa-mir-155 Atrial Fibrillation 26319023 "Expression of inflammation-associated miRNAs is significantly up-regulated in the left atrial appendage of patients with non-valvular paroxysmal atrial fibrillation, which may play a significant role in electrical and structural remodeling." -tissue_expression_up hsa-mir-19b Atrial Fibrillation 26319023 "Expression of inflammation-associated miRNAs is significantly up-regulated in the left atrial appendage of patients with non-valvular paroxysmal atrial fibrillation, which may play a significant role in electrical and structural remodeling." -tissue_expression_up hsa-mir-21 Spinal Cord Injuries 26323253 "miRâ€?46a, miRâ€?1 and miRâ€?50 expression was upregulated during H2O2 treatment." -tissue_expression_up hsa-mir-195 Prostate Neoplasms 26338045 "Collectively,this is the first report unveils that loss of miR-195 expression and thus uncontrolled BCOX1 upregulation might drive PCa metastasis." -tissue_expression_up hsa-mir-21 Cardiovascular Diseases [unspecific] 26342092 "MiR-146b-5p, -146a, -21, -150, -155, -299-5p are overexpressed in the presence of inflammation in TABs from patients with GCA." -tissue_expression_up hsa-mir-21 "Carcinoma, Breast" 26342497 Chromosome 17 aneusomy and miR-21 expression are positively correlated and can potentially serve as prognostic markers in BC. -tissue_expression_up hsa-mir-21 Glioblastoma 26344589 "The results indicate that compound 1j can enhance apoptosis, retard proliferation, and up-regulate PDCD4, a target protein of miR-21. In addition,the compound 1j does not influence the expression of multiple miRNAs and the genes that participate in miRNA universal biosynthesis pathway. These results strongly support the assumption that title compounds can serve as a small molecule inhibitor of miR-21." -tissue_expression_up hsa-mir-192 Lung Neoplasms 26351877 "Collectively, our findings suggested that curcumin inhibited cell proliferation and induced apoptosis of human non-small cell lung cancer cells through the upregulation of miR-192-5p and suppression of the PI3K/Akt signaling pathway." -tissue_expression_up hsa-mir-134 Ovarian Neoplasms 26363097 "In conclusion, our findings indicate that repression of miR-134 and consequent up-regulation of Pak2 might contribute to paclitaxel resistance." -tissue_expression_up hsa-mir-155 Gaucher Disease 26376862 sustained up-regulation of miR-155 -tissue_expression_up hsa-mir-31 "Carcinoma, Thyroid, Papillary" 26380656 "miR-21, miR-146b, miR-221, miR-222, miR-31, and miR-3613 were up-regulated" -tissue_expression_up hsa-mir-10b Medulloblastoma 26394044 microRNA-10b Is Overexpressed and Critical for Cell Survival and Proliferation in Medulloblastoma. -tissue_expression_up hsa-mir-27b "Carcinoma, Cervical" 26397063 "In summary, the present study revealed that miR-27b is upregulated by HPV16 E7 to inhibit PPAR¦Ã expression and promotes proliferation and invasion in cervical carcinoma cells." -tissue_expression_up hsa-mir-155 Muscular Dystrophy 26398013 "Up-regulation of immune-related miRNAs in muscle, for example, miR-155 and miR-146, is associated with autoimmunity" -tissue_expression_up hsa-mir-155 "Carcinoma, Breast, Triple Negative" 26398931 "These results indicate that miR-155-5p antagonizes bufalin sensitivity in TNBC cells, and that downregulation of DNMT1 and DNMT3a may be responsible for the bufalin-induced upregulation of miR-155-5p." -tissue_expression_up hsa-mir-429 Heart Failure 26408546 "17 miRNAs exhibited particularly high increases in expression, including miR-598, miR-429, miR-224, miR-425, and miR-221." -tissue_expression_up hsa-mir-21 "Carcinoma, Hepatocellular" 26436398 "We concluded that miR-21 might be complementary to alpha fetal protein in HCC diagnosis, and might serve as an attractive estimator of HCC. We also demonstrated that miR-21 overexpression was associated with HCC TNM stage and with poor survival." -tissue_expression_up hsa-mir-106a Glioma 26439036 "Elevated expression of miRNA-106a plays a crucial role in the development and progression of glioma, probably by promoting the proliferation and suppressing the apoptosis of glioma cells through the JNK/MAPK signaling pathway." -tissue_expression_up hsa-mir-34a Cardiovascular Diseases [unspecific] 26446137 "overexpression of miR-34a was significantly associated with increased apoptosis, impaired cell vitality and aggravated senescence." -tissue_expression_up hsa-mir-15a Leukemia 26456833 miR-223 and miR-15a were upregulated in 11/19 JMML bone marrow mononuclear cells harboring PTPN11 mutations -tissue_expression_up hsa-mir-223 Atherosclerosis 26492242 an obvious increase of miR-223 was observed in aortic atherosclerotic lesions. -tissue_expression_up hsa-mir-15a "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 26497405 "We detected miR-363 and miR-15a, and their expression levels were significantly increased in the HPV-16-positive patients and in FaDu cells expressing HPV-16 E6-E7." -tissue_expression_up hsa-mir-590 Vulvar Squamous Cell Carcinoma 26498065 "In conclusion, we present the miRNA expression profile in VSCC, and our findings suggest that the upregulation of miR-590-5p promotes cellular malignant behaviours via the target gene TGF¦ÂRII." -tissue_expression_up hsa-mir-92a Esophageal Neoplasms 26498375 "13 miRNAs were up-regulated including hsa-mir-153-2, hsa-mir-92a-1 and hsa-mir-182; while 27 miRNAs were down-regulated including hsa-mir comprising 29a, hsa-mir-100 and hsa-mir-139 and so on." -tissue_expression_up hsa-mir-214 "Scleroderma, Localized" 26498408 The levels of miR-214 in hair shafts of patients with dermatomyositis were significantly higher than those of normal subjects and patients with scleroderma. -tissue_expression_up hsa-mir-92b "Squamous Cell Carcinoma, Oral" 26503628 "Taken together, our results indicate that miR-92b upregulation accelerates tumor growth and present a novel mechanism of miRNA-mediated NF-¦ÊB activation in OSCC." -tissue_expression_up hsa-mir-146a Osteoarthritis 26505891 miR-146a significantly up-regulated and miR-27b significantly down-regulated at all time points -tissue_expression_up hsa-mir-145 Urinary Bladder Cancer 26514209 "Results indicate that miR-145 suppresses syndecan-1 and, by this mechanism, up-regulates stem cell factors and induces cell senescence and differentiation. We propose that miR-145 may confer stem cell-like properties on urothelial carcinoma cells and thus facilitate differentiation into multiple cell types." -tissue_expression_up hsa-let-7f Colon Neoplasms 26556872 "highly up-regulated miRNAs, let-7f-5p, miR-455-3p, miR-98, miR-155-5p and the down-regulated miRNAs, miR-1, miR-127-5p, miR-142-5p, miR-202-5p were associated with colon cancer pathways" -tissue_expression_up hsa-mir-155 Colon Neoplasms 26556872 "highly up-regulated miRNAs, let-7f-5p, miR-455-3p, miR-98, miR-155-5p and the down-regulated miRNAs, miR-1, miR-127-5p, miR-142-5p, miR-202-5p were associated with colon cancer pathways" -tissue_expression_up hsa-mir-20a Lung Neoplasms 26560875 increased expression of miR-20 in lung cancer -tissue_expression_up hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 26563758 "Higher expression levels of miR-21, AmiR-27a, and miR-218 detected in this study suggest potential roles of these miRNAs in primary resistance to EGFR-TKI in advanced NSCLC patients with EGFR exon 19 deletion mutations. These findings need to be further confirmed in a study with a larger sample size." -tissue_expression_up hsa-mir-21 Acute Kidney Failure 26577279 "A set of microRNAs was differentially expressed after renal damage, among them miR-21, which was up-regulated." -tissue_expression_up hsa-mir-183 "Carcinoma, Hepatocellular" 26640336 "miRNA-183 was the most up-regulated, followed by miRNA-373. miRNA-129 and miRNA-188 were both strongly down-regulated and miRNA-378 was down-regulated a small amount." -tissue_expression_up hsa-mir-22 Toxic Encephalopathy 26649298 "Our results demonstrated that PFOS exposure decreased miR-16 expression and increased miR-22 expression, which may represent a possible mechanism by which PFOS decreases BDNF protein levels. PFOS may inhibit BDNF-ERK-CREB signalling by increasing miR-22 levels, which may, in part, explain the mechanism of PFOS neurotoxicity." -tissue_expression_up hsa-mir-106b Cutaneous Melanoma 26662433 This study showed that miR-106b may contribute to the progression of cutaneous melanoma and its up-regulation may be independently associated with poor prognosis of cutaneous melanoma. This suggests that miR-106b might serve as a promising biological marker for further risk stratification in the management of cutaneous melanoma. -tissue_expression_up hsa-mir-210 "Carcinoma, Renal Cell, Clear-Cell" 26670229 miR-21-5p and miR-210-3p resulted the most significantly up-regulated miRNAs in this patient cohort -tissue_expression_up hsa-mir-132 Aneurysmal Subarachnoid Hemorrhage 26675167 "Our study demonstrated that as compared to healthy control, miR-132 and miR-324 showed a upregulation in both SAH DCI and Non-DCI groups. However,the differences between the SAH DCI and non-DCI groups were not statistically significant." -tissue_expression_up hsa-mir-324 Aneurysmal Subarachnoid Hemorrhage 26675167 "Our study demonstrated that as compared to healthy control, miR-132 and miR-324 showed a upregulation in both SAH DCI and Non-DCI groups. However,the differences between the SAH DCI and non-DCI groups were not statistically significant." -tissue_expression_up hsa-mir-15b "Lymphoma, Mantle-Cell" 26676972 Our present findings suggest that the upregulated expression of miR-15b is likely to play an important role in the trans-formation of cMCL to aMCL. -tissue_expression_up hsa-mir-130a Chronic Alcohol-Induced Alveolar Macrophage Dysfunction 26677910 "Alcohol increased levels of microRNA-130a/-301a, these findings demonstrate that targeting PPAR¦Ã provides a novel therapeutic approach for mitigating alcohol-induced AM derangements and susceptibility to lung infection" -tissue_expression_up hsa-mir-301a Chronic Alcohol-Induced Alveolar Macrophage Dysfunction 26677910 "Alcohol increased levels of microRNA-130a/-301a, these findings demonstrate that targeting PPAR¦Ã provides a novel therapeutic approach for mitigating alcohol-induced AM derangements and susceptibility to lung infection" -tissue_expression_up hsa-mir-205 Neoplasms [unspecific] 26681200 "miR-9, mi-R-19a, miR-22 and miR-205 that promote EMT, fibrosis and tumorigenesis were up-regulated." -tissue_expression_up hsa-mir-126 "Lymphoma, Large B-Cell, Diffuse" 26683099 "We observed increased expression of proangiomiRs Let-7f, miR-17, miR-18a, miR-19b, miR-126, miR-130a, miR-210, miR-296 and miR-378" -tissue_expression_up hsa-mir-130a "Lymphoma, Large B-Cell, Diffuse" 26683099 "We observed increased expression of proangiomiRs Let-7f, miR-17, miR-18a, miR-19b, miR-126, miR-130a, miR-210, miR-296 and miR-378" -tissue_expression_up hsa-mir-296 "Lymphoma, Large B-Cell, Diffuse" 26683099 "We observed increased expression of proangiomiRs Let-7f, miR-17, miR-18a, miR-19b, miR-126, miR-130a, miR-210, miR-296 and miR-378" -tissue_expression_up hsa-mir-378 "Lymphoma, Large B-Cell, Diffuse" 26683099 "We observed increased expression of proangiomiRs Let-7f, miR-17, miR-18a, miR-19b, miR-126, miR-130a, miR-210, miR-296 and miR-378" -tissue_expression_up hsa-mir-125b Melanoma 26684239 "miR-34a, miR-100 and miR-125b showed high expression in both resistant cells and in tumor biopsies" -tissue_expression_up hsa-mir-381 Neoplasms [unspecific] 26688820 Further study revealed that I¦ÊB¦Á was a target gene of miR-381. The upregulation of miR-381 under LPS stimulation contributes to respiratory infections mainly by targeting I¦ÊB¦Á. -tissue_expression_up hsa-mir-205 Barrett Esophagus 26711784 we observed significantly higher levels of miR-205 in tumor tissue of esophageal squamous cell carcinoma -tissue_expression_up hsa-mir-205 Choriocarcinoma 26711784 we observed significantly higher levels of miR-205 in tumor tissue of esophageal squamous cell carcinoma -tissue_expression_up hsa-mir-103a Pancreatic Neoplasms 26714641 "We identified suitable reference miRNAs for future miRNA expression experiments using CRC- and PC FFPE tissue samples. Formalin fixation decreased miRNA expression considerably, while the effect of increasing sample age was estimated to be negligible in a clinical setting." -tissue_expression_up hsa-mir-9 "Stroke, Ischemic" 26718002 The expression of miR-9 in the peri-infarct cortex was increased in the EA group compared with the MCAO group -tissue_expression_up hsa-mir-27a Glaucoma 26720444 miR-27a was significantly upregulated. -tissue_expression_up hsa-mir-146a Stroke 26738853 stroke considerably increased miR-146a density in the corpus callosum and subventricular zone (SVZ) of the lateral ventricle of the ischemic hemisphere. -tissue_expression_up hsa-mir-222 Thyroid Neoplasms 26745212 miR-221 and miR-222 are consistently upregulated in different types of thyroid carcinomas -tissue_expression_up hsa-mir-146a Inflammatory Bowel Diseases 26752469 Expression of miR-146a and -155 was higher in the inflamed mucosa of children with CD and UC than in the intact mucosa. Expression of miR-122 elevated in the macroscopically intact colonic regions of CD compared with controls and patients with UC. -tissue_expression_up hsa-mir-622 Ovarian Neoplasms 26774475 Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian Cancer. -tissue_expression_up hsa-mir-200a Colorectal Carcinoma 26790446 "The expression of MMP-2 and -9 was elevated, on the other hand, in cell lines derived from primary tumor cancer cells as well as the expression of miR-21, miR-29a, and miR-200a." -tissue_expression_up hsa-mir-21 Colorectal Carcinoma 26790446 "The expression of MMP-2 and -9 was elevated, on the other hand, in cell lines derived from primary tumor cancer cells as well as the expression of miR-21, miR-29a, and miR-200a." -tissue_expression_up hsa-mir-29a Colorectal Carcinoma 26790446 "The expression of MMP-2 and -9 was elevated, on the other hand, in cell lines derived from primary tumor cancer cells as well as the expression of miR-21, miR-29a, and miR-200a." -tissue_expression_up hsa-mir-21 Choriocarcinoma 26807210 "the expression of miR-200b, miR-200c, miR-451, miR-223 and miR-21 were significantly upregulated in mucinous cystadenocarcinoma" -tissue_expression_up hsa-mir-223 Choriocarcinoma 26807210 "the expression of miR-200b, miR-200c, miR-451, miR-223 and miR-21 were significantly upregulated in mucinous cystadenocarcinoma" -tissue_expression_up hsa-mir-15a Astrocytoma 26813564 miR-15a and miR-24-1 were found upregulated in EP relapsed and EP deceased cases -tissue_expression_up hsa-mir-15a Ependymoma 26813564 miR-15a and miR-24-1 were found upregulated in EP relapsed and EP deceased cases -tissue_expression_up hsa-mir-24 Astrocytoma 26813564 miR-15a and miR-24-1 were found upregulated in EP relapsed and EP deceased cases -tissue_expression_up hsa-mir-24 Ependymoma 26813564 miR-15a and miR-24-1 were found upregulated in EP relapsed and EP deceased cases -tissue_expression_up hsa-mir-375 "Carcinoma, Thyroid, Follicular" 26818914 Only miR-375 was over-expressed in the FNs diagnosed as carcinomas and in the PMs. -tissue_expression_up hsa-mir-21 Gastric Neoplasms 26824898 hsa-miR-21-5p was more highly expressed in the recurrence group than in the nonrecurrence group -tissue_expression_up hsa-mir-221 "Carcinoma, Lung, Non-Small-Cell" 26831656 The relative expression levels of microRNA-221 in the pathological tissues were remarkably higher than that in the corresponding normal tissues -tissue_expression_up hsa-mir-138 "Squamous Cell Carcinoma, Oral" 26841253 Upregulation of miR-138 and miR-183 was observed in 50.0% of the samples -tissue_expression_up hsa-mir-183 "Squamous Cell Carcinoma, Oral" 26841253 Upregulation of miR-138 and miR-183 was observed in 50.0% of the samples -tissue_expression_up hsa-mir-205 "Squamous Cell Carcinoma, Oral" 26841253 "Upregulation of miR-138, miRNA-145, and miR-205 was associated with advanced tumor stages, vascular invasion, and lymph node metastasis, respectively." -tissue_expression_up hsa-mir-4423 Cardiotoxicity 26842497 "early deregulation of miR-187-3p, miR-182-5p, miR-486-3p, miR-486-5p, miR-34a-3p, miR-4423-3p, miR-34c-3p, miR-34c-5p and miR-1303, and also the prolonged up-regulation of miR-182-5p, miR-4423-3p and miR-34c-5p." -tissue_expression_up hsa-mir-761 "Carcinoma, Hepatocellular" 26845057 MicroRNA-761 is upregulated in hepatocellular carcinoma and regulates tumorigenesis by targeting Mitofusin-2. -tissue_expression_up hsa-mir-21 Colorectal Carcinoma 26845148 "In the context of previous studies demonstrating increased miRNA-21 expression in metastatic primary tumors, our findings raise the question whether miRNA-21 might be involved in the initiation but not in the perpetuation and growth of metastases." -tissue_expression_up hsa-mir-155 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 26847279 "The expression of tissue and plasma miR-155 were significantly up-regulated in patients with LSCC. Our work will serve as a basis for further investigation, preferably large-scale validation in clinical trials." -tissue_expression_up hsa-mir-155 Neoplasms [unspecific] 26850462 miR-155 is an oncogenic miRNA that is often overexpressed in cancer and is associated with poor prognosis. -tissue_expression_up hsa-mir-210 "Squamous Cell Carcinoma, Esophageal" 26851030 "squamous cell carcinoma (9.26-fold, p<0.001) and adenocarcinoma cell lines (4.95-fold, p<0.001) and miR-27a-star was significantly up-regulated in adenocarcinoma cell lines (4.79-fold, p=0.04)." -tissue_expression_up hsa-mir-21 Preeclampsia 26859593 "we could observe a significant increase in gene expression of miR-155 (p<0.001), miR-21 (p<0.0001) and miR-122 (p<0.01) in preeclamptic placentas." -tissue_expression_up hsa-mir-130a Hepatitis B Virus Infection 26871786 Upregulation of miRNA-130a Represents Good Prognosis in Patients With HBV-Related Acute-on-Chronic Liver Failure: A Prospective Study. -tissue_expression_up hsa-mir-132 Inflammatory Bowel Diseases 26878986 significant upregulation of miR-132 and miR-223 was confirmed -tissue_expression_up hsa-mir-223 Inflammatory Bowel Diseases 26878986 significant upregulation of miR-132 and miR-223 was confirmed -tissue_expression_up hsa-mir-181a "Diabetes Mellitus, Type 1" 26892629 miRNA-181a expression was significantly higher in diabetic children and adolescents -tissue_expression_up hsa-mir-155 Breast Neoplasms 26901459 MiRNA-155 was selected for being overexpressed in breast cancer -tissue_expression_up hsa-mir-31 Esophageal Neoplasms 26918602 "miR-223, miR-21, and miR-31 as the top-up-regulated species" -tissue_expression_up hsa-mir-155 Vitiligo 26941046 "miR-99b, miR-125b, miR-155 and miR-199a-3p were found to be increased and miR-145 was found to be decreased in the skin of patients with vitiligo." -tissue_expression_up hsa-mir-103a Helicobacter pylori Infection 26945693 "miRNAs miR-103a-3p, miR-181c-5p, miR-370-3p, miR-375 and miR-223-3p were evaluated in tissue samples" -tissue_expression_up hsa-mir-181c Helicobacter pylori Infection 26945693 "miRNAs miR-103a-3p, miR-181c-5p, miR-370-3p, miR-375 and miR-223-3p were evaluated in tissue samples" -tissue_expression_up hsa-mir-223 Helicobacter pylori Infection 26945693 "miRNAs miR-103a-3p, miR-181c-5p, miR-370-3p, miR-375 and miR-223-3p were evaluated in tissue samples" -tissue_expression_up hsa-mir-370 Helicobacter pylori Infection 26945693 "miRNAs miR-103a-3p, miR-181c-5p, miR-370-3p, miR-375 and miR-223-3p were evaluated in tissue samples" -tissue_expression_up hsa-mir-375 Helicobacter pylori Infection 26945693 "miRNAs miR-103a-3p, miR-181c-5p, miR-370-3p, miR-375 and miR-223-3p were evaluated in tissue samples" -tissue_expression_up hsa-mir-20a "Lymphoma, Hodgkin" 26951445 miR-20a-5p were found to be increased in cHL -tissue_expression_up hsa-mir-150 Lupus Nephritis 26961386 Overexpression of miR-150 is observed in renal biopsies from patients with lupus nephritis -tissue_expression_up hsa-mir-182 Hypoxic-Ischemic Encephalopathy 26975828 miRNA-182 was highly expressed in the pineal gland. -tissue_expression_up hsa-mir-27a "Carcinoma, Cervical" 26987623 B4GALT3 up-regulation by miR-27a contributes to the oncogenic activity in human cervical cancer cells. -tissue_expression_up hsa-mir-21 Periodontitis 26987780 "Seven randomly selected up-regulated (miR-21-5p, 498, 548a-5p) and down-regulated (miR-495-3p, 539-5p, 34c-3p and 7a-2-3p) miRNAs were examined by qRT-PCR, and the results proved the accuracy of the miRNA" -tissue_expression_up hsa-mir-10b Glioma 26988656 Expression levels of miR-10b in glioma tissue were significantly higher than in normal brain tissue -tissue_expression_up hsa-mir-301a Prostate Neoplasms 26990571 High levels of miR-301a (above the median) were associated with an increased risk of biochemical recurrence -tissue_expression_up hsa-mir-210 Melanoma 27009863 Hypoxia-induced gene signatures and overexpression of the hypoxia-regulated miRNA hsa-miR-210 characterized CDXs. -tissue_expression_up hsa-mir-595 "Carcinoma, Thyroid, Papillary" 27022736 "Interestingly, in PTC cell lines and PTC tissues, expression of IL-22 and miR-595 was upregulated and Sox17 downregulated compared with normal thyroid" -tissue_expression_up hsa-mir-21 Prostate Neoplasms 27040772 the expression level of miR-21 was significantly increased in PCa tissues -tissue_expression_up hsa-mir-9 Osteosarcoma 27051003 miR-9 was significantly upregulated in OS tissues and cell lines compared to the corresponding non-cancerous bone tissues -tissue_expression_up hsa-mir-200a Melanoma 27054085 "Among the up-regulated miRNAs, miR-21, miR-200a and miR-141, are well known to be involved in carcinogenesis." -tissue_expression_up hsa-mir-142 "Squamous Cell Carcinoma, Oral" 27056547 "let-7a, let-7d, let-7f and miR-16 were downregulated while miR-29b, miR-142-3p, miR-144, miR-203, and miR-223 were upregulated in OSCC" -tissue_expression_up hsa-mir-144 "Squamous Cell Carcinoma, Oral" 27056547 "let-7a, let-7d, let-7f and miR-16 were downregulated while miR-29b, miR-142-3p, miR-144, miR-203, and miR-223 were upregulated in OSCC" -tissue_expression_up hsa-mir-203 "Squamous Cell Carcinoma, Oral" 27056547 "let-7a, let-7d, let-7f and miR-16 were downregulated while miR-29b, miR-142-3p, miR-144, miR-203, and miR-223 were upregulated in OSCC" -tissue_expression_up hsa-mir-223 "Squamous Cell Carcinoma, Oral" 27056547 "let-7a, let-7d, let-7f and miR-16 were downregulated while miR-29b, miR-142-3p, miR-144, miR-203, and miR-223 were upregulated in OSCC" -tissue_expression_up hsa-mir-29b "Squamous Cell Carcinoma, Oral" 27056547 "let-7a, let-7d, let-7f and miR-16 were downregulated while miR-29b, miR-142-3p, miR-144, miR-203, and miR-223 were upregulated in OSCC" -tissue_expression_up hsa-mir-149 "Fatty Liver, Non-Alcoholic" 27061435 miR-149 was increased in HepG2 cells treated with long-chain fatty acid (FFA) -tissue_expression_up hsa-mir-128 Glioblastoma 27063952 "The three most over-expressed miRs in the non-differentiated GSCs compared to xenografts were miR-126, -137 and -128." -tissue_expression_up hsa-mir-181a Heart Failure 27072074 "In coronary sinus samples, the microRNAs miR-16-5p, miR-27a-3p, miR-27b-3p, miR-29b-3p, miR-29c-3p, miR-30e-5p, miR-92a-3p, miR-125b-5p, miR-140-5p, miR-195-5p, miR-424-5p, and miR-451a were significantly down-regulated, and let-7a-5p, let-7c-5p, let-7e-5p, miR-23b-3p, miR-107, miR-155-5p, miR-181a-5p, miR-181b-5p and miR-320a were up-regulated in heart failure." -tissue_expression_up hsa-mir-21 "Carcinoma, Lung, Non-Small-Cell" 27072269 "miR-15a/16, miR-34a, miR-126 and miR-128 were down-regulated significantly. (>2-fold change), while miR-21 and miR.210 were up-regulated in A549." -tissue_expression_up hsa-mir-210 "Carcinoma, Lung, Non-Small-Cell" 27072269 "miR-15a/16, miR-34a, miR-126 and miR-128 were down-regulated significantly. (>2-fold change), while miR-21 and miR.210 were up-regulated in A549." -tissue_expression_up hsa-mir-146a Rheumatoid Arthritis 27079198 "miR-146a, miR-155, and miR-223 were significantly elevated in RA compared to OA synovial tissues" -tissue_expression_up hsa-mir-155 Rheumatoid Arthritis 27079198 "miR-146a, miR-155, and miR-223 were significantly elevated in RA compared to OA synovial tissues" -tissue_expression_up hsa-mir-223 Rheumatoid Arthritis 27079198 "miR-146a, miR-155, and miR-223 were significantly elevated in RA compared to OA synovial tissues" -tissue_expression_up hsa-mir-21 Breast Neoplasms 27082076 included upregulation of miR-21-5p and the miR-200 family and downregulation of let-7 family members in DCIS samples. -tissue_expression_up hsa-mir-23a Coronary Artery Disease 27085964 MiR-23a was enriched in not only diseased endothelial progenitor cells (EPCs) but also in the plasma of patients with coronary artery disease (CAD). -tissue_expression_up hsa-mir-155 "Leukemia, Lymphocytic, Chronic, B-Cell" 27111859 miR-143 was downregulated and miR-155 was overexpressed in 13q-H. -tissue_expression_up hsa-mir-146a Hepatitis C Virus Infection 27147737 miR-146a-5p level was consistently increased in HCV-infected hepatocyte-like cells -tissue_expression_up hsa-mir-155 Behcet Disease 27156371 The expression of miR-155 and IL-17 was significantly increased in CD4+ T cells of patients with active BD. -tissue_expression_up hsa-let-7b Prostate Neoplasms 27157642 up-regulation of let-7b is characteristic of prostatic TAMs -tissue_expression_up hsa-mir-125b Hepatitis C Virus Infection 27158204 "In response to HCV core protein stimulation, cytokine production was up-regulated and miR-125b expression was down-regulated in THP-1 cells." -tissue_expression_up hsa-mir-155 Renal Fibrosis 27158339 MiR-155 levels were higher in UUO mouse kidneys -tissue_expression_up hsa-mir-199a Pulmonary Hypertension 27162619 All 4 miRNAs were upregulated in the lung and right ventricle -tissue_expression_up hsa-mir-425 Cervical Neoplasms 27166306 miR-425-5p is up-regulated in cervical cancer and serum miR-425-5p may serve as a potential prognostic biomarker for cervical cancer. -tissue_expression_up hsa-mir-141 Biliary Tract Neoplasms 27172928 Overexpression of miRNA 141 is an indicator of a poor prognosis in patients with biliary tract cancer -tissue_expression_up hsa-mir-4532 Hypertension 27176897 "4 were upregulated (miRâ€?18a, miRâ€?27, miRâ€?18e and miRâ€?532) and 2 downregulated (miRâ€?8 and miRâ€?35b) in SPE placentas compared with controls." -tissue_expression_up hsa-mir-518a Hypertension 27176897 "4 were upregulated (miRâ€?18a, miRâ€?27, miRâ€?18e and miRâ€?532) and 2 downregulated (miRâ€?8 and miRâ€?35b) in SPE placentas compared with controls." -tissue_expression_up hsa-mir-518e Hypertension 27176897 "4 were upregulated (miRâ€?18a, miRâ€?27, miRâ€?18e and miRâ€?532) and 2 downregulated (miRâ€?8 and miRâ€?35b) in SPE placentas compared with controls." -tissue_expression_up hsa-mir-527 Hypertension 27176897 "4 were upregulated (miRâ€?18a, miRâ€?27, miRâ€?18e and miRâ€?532) and 2 downregulated (miRâ€?8 and miRâ€?35b) in SPE placentas compared with controls." -tissue_expression_up hsa-mir-21 Gastric Neoplasms 27179559 miR-21 is overexpressed in tumour tissue -tissue_expression_up hsa-mir-21 Salivary Gland Neoplasms 27184509 "tissue samples were studied miR-21, miR-31, miR-199a-5p, miR-146b, miR-345 were up-regulated" -tissue_expression_up hsa-mir-93 Glioma 27185265 the upregulated miR-93 level was significantly associated with the advanced malignancy. -tissue_expression_up hsa-mir-10b "Carcinoma, Nasopharyngeal" 27186392 we show that microRNA-10b (miR-10b) is up-regulated in HNE1/DDP cells -tissue_expression_up hsa-mir-182 Alcoholic Hepatitis 27196584 miR-182 was the most highly expressed miRNA in AH -tissue_expression_up hsa-mir-301b Pancreatic Neoplasms 27197190 PDAC tumors expressing high levels of MIF displayed elevated levels of miR-301b and reduced levels of NR3C2. -tissue_expression_up hsa-mir-183 Glioma 27215622 "In conclusion, our study indicated that miR-183 was upregulated in glioma, and that it may be used as a potential biomarker of poor prognosis in patients with glioma." -tissue_expression_up hsa-mir-206 Soft Tissue Sarcoma 27223121 "At least threefold overexpression of one of miR-206,-381, and 671-5p was detected in all MPNSTs, EMCSs, SSs and 7 MCs." -tissue_expression_up hsa-mir-381 Soft Tissue Sarcoma 27223121 "At least threefold overexpression of one of miR-206,-381, and 671-5p was detected in all MPNSTs, EMCSs, SSs and 7 MCs." -tissue_expression_up hsa-mir-671 Soft Tissue Sarcoma 27223121 "At least threefold overexpression of one of miR-206,-381, and 671-5p was detected in all MPNSTs, EMCSs, SSs and 7 MCs." -tissue_expression_up hsa-mir-29a Acute Pancreatitis 27239114 The expression of miR-29a was much higher in the AEP group compared with the control group -tissue_expression_up hsa-mir-126 Asthma 27247924 "Elevated levels of miRNA-126, IL-13 mRNA and pathological changes were observed in the sensitized group compared to the control group" -tissue_expression_up hsa-mir-1287 Colorectal Carcinoma 27251300 MiR-1287 was significantly upregulated in the group of CRC samples compared with matched noncancerous tissue samples. -tissue_expression_up hsa-mir-128a Preeclampsia 27261578 miR-128a is an up-regulated miRNA in patient with PE. -tissue_expression_up hsa-mir-181a Colorectal Carcinoma 27264420 IL-1β induced the expression of miR-181a. -tissue_expression_up hsa-mir-196 "Adenocarcinoma, Pancreatic Ductal" 27267055 The expressions of all microRNAs were 1.4-3.7 times higher (significantly) in the PAC group compared to non-cancer patients. -tissue_expression_up hsa-mir-200 "Adenocarcinoma, Pancreatic Ductal" 27267055 The expressions of all microRNAs were 1.4-3.7 times higher (significantly) in the PAC group compared to non-cancer patients. -tissue_expression_up hsa-mir-21 Cervical Neoplasms 27278606 the expression of miR-21 was upregulated and the expression of miR-143 was downregulated by the HPV16 E7 oncoprotein in vivo -tissue_expression_up hsa-mir-199a Obesity 27279151 miRâ€?99aâ€?p may represent a factor in the modulation of obesity‑associated IR -tissue_expression_up hsa-mir-9 Neoplasms [unspecific] 27284255 higher expression level of miR-9 significantly predicted worse OS in various carcinomas -tissue_expression_up hsa-mir-126 Atherosclerosis 27288564 "Aroclor 1260 increased miR-21, miR-31, miR-126, miR-221 and miR-222 expression levels." -tissue_expression_up hsa-mir-21 Atherosclerosis 27288564 "Aroclor 1260 increased miR-21, miR-31, miR-126, miR-221 and miR-222 expression levels." -tissue_expression_up hsa-mir-221 Atherosclerosis 27288564 "Aroclor 1260 increased miR-21, miR-31, miR-126, miR-221 and miR-222 expression levels." -tissue_expression_up hsa-mir-222 Atherosclerosis 27288564 "Aroclor 1260 increased miR-21, miR-31, miR-126, miR-221 and miR-222 expression levels." -tissue_expression_up hsa-mir-31 Atherosclerosis 27288564 "Aroclor 1260 increased miR-21, miR-31, miR-126, miR-221 and miR-222 expression levels." -tissue_expression_up hsa-mir-181b "Carcinoma, Lung, Non-Small-Cell" 27291819 miR-181b-5p was up-regulated in squamous cell carcinoma -tissue_expression_up hsa-mir-133a "Cardiomyopathy, Dilated" 27292200 "Endomyocardial expression of miR-155 and miR-133a, as quantified by reverse transcription-PCR (RT-PCR), was up-regulated in patients with iCMP as compared with patients with DCM." -tissue_expression_up hsa-mir-182 Ovarian Neoplasms 27295517 miR-182 expression is significantly increased in EOC -tissue_expression_up hsa-mir-106b "Carcinoma, Hepatocellular" 27298561 The value of miR-106b expression in HBV-associated HCC patients was significantly higher -tissue_expression_up hsa-mir-200c Interstitial Lung Disease 27309544 "The miR-200c level in the SSc group was significantly higher than in the DM/PM, pSS, and RA groups" -tissue_expression_up hsa-mir-155 Multiple Sclerosis 27310932 up-regulation of miR-155 (p value = 0.009) and miR-132 (p value = 0.04) in MS patients -tissue_expression_up hsa-mir-208a Myocardial Infarction 27314868 over-expression of miR-208a in myocardial infarction tissue -tissue_expression_up hsa-mir-486 Kideny Transplant Rejection 27323802 iR-486-5p and its target PTEN/foxO3 mRNA were significantly overexpressed (pâ€?â€?.01) and underexpressed (pâ€?â€?.01) -tissue_expression_up hsa-mir-301a Prostate Neoplasms 27327120 MiR-301a and miR-301b are 2 hypoxia responsive miRNAs that are significantly upregulated in hypoxia in prostate cancer cells. -tissue_expression_up hsa-mir-301b Prostate Neoplasms 27327120 MiR-301a and miR-301b are 2 hypoxia responsive miRNAs that are significantly upregulated in hypoxia in prostate cancer cells. -tissue_expression_up hsa-mir-9 Cervical Neoplasms 27345415 MiR-9 up-regulated in cervical cancer -tissue_expression_up hsa-mir-126 "Shock, Hemorrhagic" 27345902 miR-29a and miR-126 were upregulated -tissue_expression_up hsa-mir-29a "Shock, Hemorrhagic" 27345902 miR-29a and miR-126 were upregulated -tissue_expression_up hsa-mir-29b Colorectal Carcinoma 27346400 The expression level of miR-29b is reduced in colorectal cancer tissues compared with that in the adjacent colorectal tissues. -tissue_expression_up hsa-mir-146b "Carcinoma, Thyroid" 27347103 "the expression levels of miR146b, miR221 and miR222 were significantly higher" -tissue_expression_up hsa-mir-221 "Carcinoma, Thyroid" 27347103 "the expression levels of miR146b, miR221 and miR222 were significantly higher" -tissue_expression_up hsa-mir-100 Bladder Neoplasms 27350368 "six up-regulated candidate miRNAs (miR-182-5p, miR-935, miR-518e-3p, miR-573, miR-100-3p, and miR-3171)" -tissue_expression_up hsa-mir-182 Bladder Neoplasms 27350368 "six up-regulated candidate miRNAs (miR-182-5p, miR-935, miR-518e-3p, miR-573, miR-100-3p, and miR-3171)" -tissue_expression_up hsa-mir-3171 Bladder Neoplasms 27350368 "six up-regulated candidate miRNAs (miR-182-5p, miR-935, miR-518e-3p, miR-573, miR-100-3p, and miR-3171)" -tissue_expression_up hsa-mir-518e Bladder Neoplasms 27350368 "six up-regulated candidate miRNAs (miR-182-5p, miR-935, miR-518e-3p, miR-573, miR-100-3p, and miR-3171)" -tissue_expression_up hsa-mir-573 Bladder Neoplasms 27350368 "six up-regulated candidate miRNAs (miR-182-5p, miR-935, miR-518e-3p, miR-573, miR-100-3p, and miR-3171)" -tissue_expression_up hsa-mir-935 Bladder Neoplasms 27350368 "six up-regulated candidate miRNAs (miR-182-5p, miR-935, miR-518e-3p, miR-573, miR-100-3p, and miR-3171)" -tissue_expression_up hsa-mir-192 Hepatitis C Virus Infection 27350618 miR-192 expression was induced by HCV infection -tissue_expression_up hsa-mir-21 Proliferative Vitreoretinal Disease 27351379 miR-21 expression positively correlates with disease progression -tissue_expression_up hsa-mir-372 "Carcinoma, Urothelial" 27351382 "high primary tumour levels of E2F1, miR-21 and miR-372 are associated with poor PFS independent of clinical prognostic factors." -tissue_expression_up hsa-mir-222 Thyroid Neoplasms 27353001 miR-25 and miR-222 expression was upregulated in 8505C -tissue_expression_up hsa-mir-25 Thyroid Neoplasms 27353001 miR-25 and miR-222 expression was upregulated in 8505C -tissue_expression_up hsa-mir-34 Idiopathic Pulmonary Fibrosis 27362652 "miR-34a, miR-34b, and miR-34c, but not miR-20a, miR-29c, or miR-let-7f were significantly higher in type II AECs from IPF patients." -tissue_expression_up hsa-mir-506 "Adenocarcinoma, Pancreatic Ductal" 27371108 miR-506 expression was higher in PDAC -tissue_expression_up hsa-mir-143 Barrett Esophagus 27374102 "miR-143, miR-145, miR-194 and miR-215 levels were significantly higher" -tissue_expression_up hsa-mir-143 Choriocarcinoma 27374102 "miR-143, miR-145, miR-194 and miR-215 levels were significantly higher" -tissue_expression_up hsa-mir-194 Barrett Esophagus 27374102 "miR-143, miR-145, miR-194 and miR-215 levels were significantly higher" -tissue_expression_up hsa-mir-215 Barrett Esophagus 27374102 "miR-143, miR-145, miR-194 and miR-215 levels were significantly higher" -tissue_expression_up hsa-mir-210 Cerebral Ischemia 27386874 "miR-210 expression in the hippocampus of the I/R group at 6, 24 and 96 h after reperfusion was significantly increased at each time point, while its expression in the group treated with HRS was significantly decreased." -tissue_expression_up hsa-mir-34 Liver Fibrosis 27387128 Further studies showed that the miR-34a/SIRT1/p53 signaling pathway was activated in hepatocytes but not in HSCs. -tissue_expression_up hsa-mir-34a Liver Fibrosis 27387128 "In the present study, using a CCl4-induced rat liver fibrosis model, we found that the miR-34a/SIRT1/p53 signaling pathway was activated and could be inhibited by SIRT1 activator SRT1720." -tissue_expression_up hsa-mir-141 Sarcoma [unspecific] 27402864 combined expression of miR-200s and GRHL2 further upregulates epithelial genes to induce MET. -tissue_expression_up hsa-mir-200a Sarcoma [unspecific] 27402864 combined expression of miR-200s and GRHL2 further upregulates epithelial genes to induce MET. -tissue_expression_up hsa-mir-200b Sarcoma [unspecific] 27402864 combined expression of miR-200s and GRHL2 further upregulates epithelial genes to induce MET. -tissue_expression_up hsa-mir-200c Sarcoma [unspecific] 27402864 combined expression of miR-200s and GRHL2 further upregulates epithelial genes to induce MET. -tissue_expression_up hsa-mir-429 Sarcoma [unspecific] 27402864 combined expression of miR-200s and GRHL2 further upregulates epithelial genes to induce MET. -tissue_expression_up hsa-let-7a "Carcinoma, Breast, Triple Negative" 27404381 "Interestingly, despite being a known tumor suppressor, Let-7a showed a significant overexpression in TNBCs." -tissue_expression_up hsa-mir-21 "Carcinoma, Breast, Triple Negative" 27404381 "While miR-21, miR-221 and miR-210 showed significant over-expression, miR-195 and miR-145 were downregulated and well correlated with various clinicopathological and demographic risk factors, tumor grade, clinical stage and hormone receptor status." -tissue_expression_up hsa-mir-210 "Carcinoma, Breast, Triple Negative" 27404381 "While miR-21, miR-221 and miR-210 showed significant over-expression, miR-195 and miR-145 were downregulated and well correlated with various clinicopathological and demographic risk factors, tumor grade, clinical stage and hormone receptor status." -tissue_expression_up hsa-mir-221 "Carcinoma, Breast, Triple Negative" 27404381 "While miR-21, miR-221 and miR-210 showed significant over-expression, miR-195 and miR-145 were downregulated and well correlated with various clinicopathological and demographic risk factors, tumor grade, clinical stage and hormone receptor status." -tissue_expression_up hsa-mir-483 Atrial Fibrillation 27422887 Sixteen microRNAs were differentially expressed in the atrial myocardium of POAF patients when compared with those maintaining sinus rhythm. miR-208a was the most underexpressed [fold change (FC) = 2.458] and miR-483-5p the most overexpressed (FC = 1.804). -tissue_expression_up hsa-mir-221 "Carcinoma, Renal Cell, Clear-Cell" 27427222 miRNA-21 and miRNA-221 expressions were significantly up-regulated in tumor specimens compared to normal tissue (P<0.05). -tissue_expression_up hsa-mir-375 "Squamous Cell Carcinoma, Laryngeal or Hypopharyngeal" 27446362 "The results of the present study suggested that miR-148a and miR-375 were significantly upregulated in LSCC tissues, and increased expression of miR-375 was associated with a more aggressive phenotype of LSCC." -tissue_expression_up hsa-mir-146a Crohn Disease 27468194 The elevated expression of miR-146a and -155 in the inflamed duodenal mucosa of CD patients suggests the role of these miRs in the pathomechanism of inflammatory bowel disease. -tissue_expression_up hsa-mir-155 Crohn Disease 27468194 The elevated expression of miR-146a and -155 in the inflamed duodenal mucosa of CD patients suggests the role of these miRs in the pathomechanism of inflammatory bowel disease. -tissue_expression_up hsa-mir-155 Melanoma 27469124 "A comparison of Spitzoid melanomas to benign nevi revealed overexpression of miR-21, miR-150, and miR-155 in the malignant primaries (p < 0.05)." -tissue_expression_up hsa-mir-155 Lymphoma 27473081 "T-MF showed higher miR17 and miR-18a expression compared to F-MF and TR-MF (p â‰?0.0387) while miR19b, miR92a, and miR-155 showed increased levels in F-MF and TR-MF with respect to T-MF (p â‰?0.0360)." -tissue_expression_up hsa-mir-17 Lymphoma 27473081 "Furthermore, MF patients showed higher miRNA expression compared to controls (p â‰?0.0223). T-MF showed higher miR17 and miR-18a expression compared to F-MF and TR-MF (p â‰?0.0387) while miR19b, miR92a, and miR-155 showed increased levels in F-MF and TR-MF with respect to T-MF (p â‰?0.0360)." -tissue_expression_up hsa-mir-18a Lymphoma 27473081 "Furthermore, MF patients showed higher miRNA expression compared to controls (p â‰?0.0223). T-MF showed higher miR17 and miR-18a expression compared to F-MF and TR-MF (p â‰?0.0387) while miR19b, miR92a, and miR-155 showed increased levels in F-MF and TR-MF with respect to T-MF (p â‰?0.0360)." -tissue_expression_up hsa-mir-19b Lymphoma 27473081 "Furthermore, MF patients showed higher miRNA expression compared to controls (p â‰?0.0223). T-MF showed higher miR17 and miR-18a expression compared to F-MF and TR-MF (p â‰?0.0387) while miR19b, miR92a, and miR-155 showed increased levels in F-MF and TR-MF with respect to T-MF (p â‰?0.0360)." -tissue_expression_up hsa-mir-92a Lymphoma 27473081 "Furthermore, MF patients showed higher miRNA expression compared to controls (p â‰?0.0223). T-MF showed higher miR17 and miR-18a expression compared to F-MF and TR-MF (p â‰?0.0387) while miR19b, miR92a, and miR-155 showed increased levels in F-MF and TR-MF with respect to T-MF (p â‰?0.0360)." -tissue_expression_up hsa-mir-146b Otitis Media 27497395 Middle ear miR-146a and miR-146b expression was elevated in otitis media patients relative to control subjects and correlated with middle ear epithelial thickness. -tissue_expression_up hsa-mir-221 "Adenocarcinoma, Esophageal" 27501171 MiR-221 was overexpressed in 5-FU resistant EC cell lines as well as in human EAC tissue. -tissue_expression_up hsa-mir-181b "Squamous Cell Carcinoma, Oral" 27509922 he expression levels of miRâ€?81b and Bclâ€? in OVC were significantly higher compared with normal mucosal tissue (NM); -tissue_expression_up hsa-mir-34b Seizures 27514646 "We discovered that miR-34b-5p, a member of the miR-34 family, increased significantly in flurothyl-treated rat hippocampus tissue." -tissue_expression_up hsa-mir-210 Male Infertility 27535712 " Compared with obstructive azoospermia (OA) as normal control, our results suggest that miR-210 was significantly up-regulated in testis of patients with NOA (P<0.05)" -tissue_expression_up hsa-let-7b Chronic Inflammation 27539004 "PM2.5 exposure increased miR-3560 and let-7b-5p in the hippocampus, two proteins that regulate genes Oxct1 and Lin28b that control ketogenesis and glycosylation, and neural cell differentiation, respectively" -tissue_expression_up hsa-mir-3560 Chronic Inflammation 27539004 "PM2.5 exposure increased miR-3560 and let-7b-5p in the hippocampus, two proteins that regulate genes Oxct1 and Lin28b that control ketogenesis and glycosylation, and neural cell differentiation, respectively" -tissue_expression_up hsa-mir-3588 Chronic Inflammation 27539004 "Expression levels of cortical miR-6315, miR-3588, and miR-466b-5p were upregulated" -tissue_expression_up hsa-mir-466b Chronic Inflammation 27539004 "Expression levels of cortical miR-6315, miR-3588, and miR-466b-5p were upregulated" -tissue_expression_up hsa-mir-6315 Chronic Inflammation 27539004 "Expression levels of cortical miR-6315, miR-3588, and miR-466b-5p were upregulated" -tissue_expression_up hsa-mir-34a "Stroke, Ischemic" 27545688 Increased Expression of mir-34a-5p and Clinical Association in Acute Ischemic Stroke Patients and in a Rat Model. -tissue_expression_up hsa-mir-16 "Carcinoma, Gastric" 27605261 High expression of miR-16 and miR-451 predicating better prognosis in patients with gastric cancer. -tissue_expression_up hsa-mir-451 "Carcinoma, Gastric" 27605261 High expression of miR-16 and miR-451 predicating better prognosis in patients with gastric cancer. -tissue_expression_up hsa-mir-126 "Carcinoma, Ovarian, Clear Cell" 27612152 MicroRNA Gene Expression Signature Driven by miR-9 Overexpression in Ovarian Clear Cell Carcinoma. -tissue_expression_up hsa-mir-9 "Carcinoma, Ovarian, Clear Cell" 27612152 MicroRNA Gene Expression Signature Driven by miR-9 Overexpression in Ovarian Clear Cell Carcinoma. -tissue_expression_up hsa-mir-107 "Adenocarcinoma, Colon" 27658891 "the top most upregulated and downregulated miRNAs in HPNM included miR-145, -143, -107, -194, and -26a (upregulated), and miR-663, -1268, -320b, -1275, and -322b (downregulated)" -tissue_expression_up hsa-mir-143 "Adenocarcinoma, Colon" 27658891 "the top most upregulated and downregulated miRNAs in HPNM included miR-145, -143, -107, -194, and -26a (upregulated), and miR-663, -1268, -320b, -1275, and -321b (downregulated)" -tissue_expression_up hsa-mir-145 "Adenocarcinoma, Colon" 27658891 "the top most upregulated and downregulated miRNAs in HPNM included miR-145, -143, -107, -194, and -26a (upregulated), and miR-663, -1268, -320b, -1275, and -320b (downregulated)" -tissue_expression_up hsa-mir-194 "Adenocarcinoma, Colon" 27658891 "the top most upregulated and downregulated miRNAs in HPNM included miR-145, -143, -107, -194, and -26a (upregulated), and miR-663, -1268, -320b, -1275, and -323b (downregulated)" -tissue_expression_up hsa-mir-26a "Adenocarcinoma, Colon" 27658891 "the top most upregulated and downregulated miRNAs in HPNM included miR-145, -143, -107, -194, and -26a (upregulated), and miR-663, -1268, -320b, -1275, and -324b (downregulated)" -tissue_expression_up hsa-mir-98 Osteoarthritis 27676099 Upregulation of miR-98 Inhibits Apoptosis in Cartilage Cells in Osteoarthritis. -tissue_expression_up hsa-mir-155 Psoriasis 27706699 Increased miR-155-5p expression in dermal mesenchymal stem cells of psoriatic patients: comparing the microRNA expression profile by microarray. -tissue_expression_up hsa-mir-203 Psoriasis 27729619 upregulation of miR-31/miR-203 and downregulation of hsa-miR-99a/miR-125b work together in concert to facilitate the development of psoriasis pathogenesis -tissue_expression_up hsa-mir-31 Psoriasis 27729619 upregulation of miR-31/miR-203 and downregulation of hsa-miR-99a/miR-125b work together in concert to facilitate the development of psoriasis pathogenesis -tissue_expression_up hsa-mir-140 "Carcinoma, Breast" 27746365 "MiR-222, miR-29a, miR-34a, miR-423, miR-140, miR-3178, miR-574, miR-6780b and miR-744 exhibited significantly higher expression levels in surgically-resected specimens compared with pre-neoadjuvant chemotherapy biopsies" -tissue_expression_up hsa-mir-222 "Carcinoma, Breast" 27746365 "MiR-222, miR-29a, miR-34a, miR-423, miR-140, miR-3178, miR-574, miR-6780b and miR-744 exhibited significantly higher expression levels in surgically-resected specimens compared with pre-neoadjuvant chemotherapy biopsies" -tissue_expression_up hsa-mir-29a "Carcinoma, Breast" 27746365 "MiR-222, miR-29a, miR-34a, miR-423, miR-140, miR-3178, miR-574, miR-6780b and miR-744 exhibited significantly higher expression levels in surgically-resected specimens compared with pre-neoadjuvant chemotherapy biopsies" -tissue_expression_up hsa-mir-3178 "Carcinoma, Breast" 27746365 "MiR-222, miR-29a, miR-34a, miR-423, miR-140, miR-3178, miR-574, miR-6780b and miR-744 exhibited significantly higher expression levels in surgically-resected specimens compared with pre-neoadjuvant chemotherapy biopsies" -tissue_expression_up hsa-mir-34a "Carcinoma, Breast" 27746365 "MiR-222, miR-29a, miR-34a, miR-423, miR-140, miR-3178, miR-574, miR-6780b and miR-744 exhibited significantly higher expression levels in surgically-resected specimens compared with pre-neoadjuvant chemotherapy biopsies" -tissue_expression_up hsa-mir-423 "Carcinoma, Breast" 27746365 "MiR-222, miR-29a, miR-34a, miR-423, miR-140, miR-3178, miR-574, miR-6780b and miR-744 exhibited significantly higher expression levels in surgically-resected specimens compared with pre-neoadjuvant chemotherapy biopsies" -tissue_expression_up hsa-mir-574 "Carcinoma, Breast" 27746365 "MiR-222, miR-29a, miR-34a, miR-423, miR-140, miR-3178, miR-574, miR-6780b and miR-744 exhibited significantly higher expression levels in surgically-resected specimens compared with pre-neoadjuvant chemotherapy biopsies" -tissue_expression_up hsa-mir-6780b "Carcinoma, Breast" 27746365 "MiR-222, miR-29a, miR-34a, miR-423, miR-140, miR-3178, miR-574, miR-6780b and miR-744 exhibited significantly higher expression levels in surgically-resected specimens compared with pre-neoadjuvant chemotherapy biopsies" -tissue_expression_up hsa-mir-744 "Carcinoma, Breast" 27746365 "MiR-222, miR-29a, miR-34a, miR-423, miR-140, miR-3178, miR-574, miR-6780b and miR-744 exhibited significantly higher expression levels in surgically-resected specimens compared with pre-neoadjuvant chemotherapy biopsies" -tissue_expression_up hsa-mir-222 "Carcinoma, Breast" 27746366 MiR-222 promotes drug-resistance of breast cancer cells to adriamycin via modulation of PTEN/Akt/FOXO1 pathway. -tissue_expression_up hsa-mir-543 "Carcinoma, Lung, Non-Small-Cell" 27769862 miR-543 is up-regulated in gefitinib-resistant non-small cell lung cancer and promotes cell proliferation and invasion via phosphatase and tensin homolog. -tissue_expression_up hsa-mir-223 Obesity 27812198 Visceral Adipose MicroRNA 223 Is Upregulated in Human and Murine Obesity and Modulates the Inflammatory Phenotype of Macrophages. -tissue_expression_up hsa-mir-124 "Squamous Cell Carcinoma, Skin or Unspecific" 27818465 The expression of miR-124 increases in aged skin to cause cell senescence and it decreases in squamous cell carcinoma. -tissue_expression_up hsa-mir-16 Rheumatoid Arthritis 27875659 Upregulated Expression of microRNA-16 Correlates with Th17/Treg Cell Imbalance in Patients with Rheumatoid Arthritis. -tissue_expression_up hsa-mir-16 "Adenocarcinoma, Colon" 27930363 Upregulated miR-16 expression is an independent indicator of relapse and poor overall survival of colorectal adenocarcinoma patients. -tissue_expression_up hsa-mir-24 "Adenocarcinoma, Colon" 27939727 Elevated expression of miR-24-3p is a potentially adverse prognostic factor in colorectal adenocarcinoma. -tissue_expression_up hsa-mir-222 "Carcinoma, Gastric" 27994199 Upregulation of miR-222 in both Helicobacter pylori- infected and noninfected gastric cancer patients. -tissue_expression_up hsa-mir-23a Muscle Atrophy 28000445 Delphinidin Prevents Muscle Atrophy and Upregulates miR-23a Expression. -tissue_expression_up hsa-mir-15a Glioma 28060761 "Sensitivity and specificity analysis indicated miR-15a, miR-16, miR-21, miR-23a, and miR-9 were up-regulated, while miR-124 was down-regulated in glioma" -tissue_expression_up hsa-mir-16 Glioma 28060761 "Sensitivity and specificity analysis indicated miR-15a, miR-16, miR-21, miR-23a, and miR-9 were up-regulated, while miR-124 was down-regulated in glioma" -tissue_expression_up hsa-mir-21 Glioma 28060761 "Sensitivity and specificity analysis indicated miR-15a, miR-16, miR-21, miR-23a, and miR-9 were up-regulated, while miR-124 was down-regulated in glioma" -tissue_expression_up hsa-mir-23a Glioma 28060761 "Sensitivity and specificity analysis indicated miR-15a, miR-16, miR-21, miR-23a, and miR-9 were up-regulated, while miR-124 was down-regulated in glioma" -tissue_expression_up hsa-mir-9 Glioma 28060761 "Sensitivity and specificity analysis indicated miR-15a, miR-16, miR-21, miR-23a, and miR-9 were up-regulated, while miR-124 was down-regulated in glioma" -tissue_expression_up hsa-mir-21 "Carcinoma, Skin" 28069514 "Increased microRNA 21 expression contributes to arsenic induced skin lesions, skin cancers and respiratory distress in chronically exposed individuals." -tissue_expression_up hsa-mir-125b Acute Peritonitis 28074870 MicroRNA-155 is upregulated in ascites in patients with spontaneous bacterial peritonitis. -tissue_expression_up hsa-mir-143 "Carcinoma, Nasopharyngeal" 28105209 Upregulated microRNA-143 inhibits cell proliferation in human nasopharyngeal carcinoma. -tissue_expression_up hsa-mir-21 "Carcinoma, Renal Cell" 28184919 Upregulation of miR-21 expression is a valuable predicator of advanced clinicopathological features and poor prognosis in patients with renal cell carcinoma through the p53/p21?cyclin?E2?Bax/caspase-3 signaling pathway. -tissue_expression_up hsa-mir-605 "Carcinoma, Renal Cell" 28222071 miR-605 is elevated at baseline in the Responders and is downregulated with treatment in Responders as compared with Progressors -tissue_expression_up hsa-mir-193a Nephrotic Syndrome 28299339 The miR-193a expression levels only slightly increased in NS patients -tissue_expression_up hsa-let-7b Endocrine Gland Neoplasms 28322989 "Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)" -tissue_expression_up hsa-mir-146b Endocrine Gland Neoplasms 28322989 "Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)" -tissue_expression_up hsa-mir-183 Endocrine Gland Neoplasms 28322989 "Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)" -tissue_expression_up hsa-mir-21 Endocrine Gland Neoplasms 28322989 "Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)" -tissue_expression_up hsa-mir-221 Endocrine Gland Neoplasms 28322989 "Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)" -tissue_expression_up hsa-mir-222 Endocrine Gland Neoplasms 28322989 "Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)" -tissue_expression_up hsa-mir-25 Endocrine Gland Neoplasms 28322989 "Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)" -tissue_expression_up hsa-mir-31 Endocrine Gland Neoplasms 28322989 "Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)" -tissue_expression_up hsa-mir-584 Endocrine Gland Neoplasms 28322989 "Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)" -tissue_expression_up hsa-mir-595 Endocrine Gland Neoplasms 28322989 "Several miRNAs show lowered expression in endocrine cancers (i.e. miR-200s, miR-126, miR-7, miR-29a, miR-30a, miR-137, miR-206, miR-101, miR-613, miR-539, miR-205, miR-9, miR-195), while others are commonly overexpressed (i.e. miR-21, miR-183, miR-31, miR-let7b, miR-584, miR-146b, miR-221, miR-222, miR-25, miR-595)" -tissue_expression_up hsa-mir-210 Lung Neoplasms 28334118 "we found that hsa-mir-210 was upregulated, while hsa-mir-490 and hsa-mir-486 were downregulated in?>?90% of the 991 lung cancer samples" -tissue_expression_up hsa-mir-888 "Carcinoma, Hepatocellular" 28337887 Up-regulation of miR-888-5p in hepatocellular carcinoma cell lines and its effect on malignant characteristics of cells. -tissue_expression_up hsa-mir-137 "Carcinoma, Hepatocellular" 28350139 Upregulation of miR-137 reverses sorafenib resistance and cancer-initiating cell phenotypes by degrading ANT2 in hepatocellular carcinoma. -tissue_expression_up hsa-mir-223 "Carcinoma, Gastrooesophageal" 28395057 Early miR-223 Upregulation in Gastroesophageal Carcinogenesis. -tissue_expression_up hsa-let-7a "Carcinoma, Gastric" 28399984 Up-regulation of Let-7a Expression Induces Gastric Carcinoma Cell Apoptosis In Vitro. -tissue_expression_up hsa-mir-21 "Fibromatosis, Aggressive" 28418912 "The correlation between sporadic DTs and miRNA expression showed that miR-21-3p increased in mutated versus wild-type DTs, while miR-197-3p was decreased" -tissue_expression_up hsa-mir-93 Glioma 28440610 Evaluation Expression of Microrna-93 and Integrin ¦¢8 in Different Types of Glioma Tumors -tissue_expression_up hsa-mir-182 Behcet Disease 28482290 "up regulation of miR-182 and miR-3591-3p; down regulation of miR-155, miR-638 and miR-4488 in the pathogenesis of the disease" -tissue_expression_up hsa-mir-3591 Behcet Disease 28482290 "up regulation of miR-182 and miR-3591-3p; down regulation of miR-155, miR-638 and miR-4488 in the pathogenesis of the disease" -tissue_expression_up hsa-mir-101 Colon Neoplasms 28560419 Upregulation of miR-101 enhances the cytotoxic effect of anticancer drugs through inhibition of colon cancer cell proliferation. -tissue_expression_up hsa-mir-143 Breast Neoplasms 28588724 Upregulation of microRNA-143 reverses drug resistance in human breast cancer cells via inhibition of cytokine-induced apoptosis inhibitor 1. -tissue_expression_up hsa-mir-199a Colorectal Carcinoma 28639895 Upregulation of miR-199a/b contributes to cisplatin resistance via Wnt/¦Â-catenin-ABCG2 signaling pathway in ALDHA1+ colorectal cancer stem cells. -tissue_expression_up hsa-mir-199b Colorectal Carcinoma 28639895 Upregulation of miR-199a/b contributes to cisplatin resistance via Wnt/¦Â-catenin-ABCG2 signaling pathway in ALDHA1+ colorectal cancer stem cells. -tissue_expression_up hsa-mir-9 "Carcinoma, Hepatocellular" 28774651 "inhibition of hsa_circ_0071410 increased the expression of miR-9-5p, resulting in the attenuation of irradiation induced HSC activation" -tissue_expression_up hsa-mir-155 Systemic Lupus Erythematosus 28779021 "IFN-¦Á impairs insulin-mediated NO production, and altered gene expression resulted from eNOS instability, possibly due to enhanced miR-155 expression" -tissue_expression_up hsa-mir-126 Vasomotor Rhinitis 28787742 "there was significant overexpression of miR-543, miR-129-5p, and miR-126-3p, and under-expression of miR-2110, miR-449c-5p, miR-449b-5p, miR-190b, and miR-92b-5p." -tissue_expression_up hsa-mir-129 Vasomotor Rhinitis 28787742 "there was significant overexpression of miR-543, miR-129-5p, and miR-126-3p, and under-expression of miR-2110, miR-449c-5p, miR-449b-5p, miR-190b, and miR-92b-5p." -tissue_expression_up hsa-mir-543 Vasomotor Rhinitis 28787742 "there was significant overexpression of miR-543, miR-129-5p, and miR-126-3p, and under-expression of miR-2110, miR-449c-5p, miR-449b-5p, miR-190b, and miR-92b-5p." -tissue_expression_up hsa-mir-125a "Lymphoma, Large B-Cell, Diffuse" 28817403 "PB-DLBCL and DLBCL-GCB-CC also had much higher levels of miR-125a-3p, miR-34-3p, and miR-155-5p, and significantly lower levels of miR-17-5p and miR-17-3p" -tissue_expression_up hsa-mir-155 "Lymphoma, Large B-Cell, Diffuse" 28817403 "PB-DLBCL and DLBCL-GCB-CC also had much higher levels of miR-125a-3p, miR-34-3p, and miR-155-5p, and significantly lower levels of miR-17-5p and miR-17-3p" -tissue_expression_up hsa-mir-34 "Lymphoma, Large B-Cell, Diffuse" 28817403 "PB-DLBCL and DLBCL-GCB-CC also had much higher levels of miR-125a-3p, miR-34-3p, and miR-155-5p, and significantly lower levels of miR-17-5p and miR-17-3p" -tissue_expression_up hsa-mir-125b Colorectal Carcinoma 28881590 Upregulation of microRNA-125b by G-CSF promotes metastasis in colorectal cancer -tissue_expression_up hsa-mir-210 "Adenocarcinoma, Esophageal" 28968550 "Expression levels of miR-25 and miR-210 were significantly higher, and those of PTEN and AIFM3 significantly lower" -tissue_expression_up hsa-mir-25 "Adenocarcinoma, Esophageal" 28968550 "Expression levels of miR-25 and miR-210 were significantly higher, and those of PTEN and AIFM3 significantly lower" -tissue_expression_up hsa-mir-223 Chorioamnionitis 29083107 Increased miR-223 expression in foetal organs is a signature of acute chorioamnionitis with systemic consequences. -tissue_expression_up hsa-mir-214 "Carcinoma, Hepatocellular" 29088870 high miR-214 could be a promising biomarker for prognosis prediction of cancer -tissue_expression_up hsa-mir-21 "Carcinoma, Thyroid, Medullary" 29107050 MicroRNA-21 and long non-coding RNA MALAT1 are overexpressed markers in medullary thyroid carcinoma. -tissue_expression_up hsa-mir-16 Glioblastoma 29110584 "Our data demonstrated a significant upregulation of five microRNAs (hsa-miR-16, hsa-miR-17, hsa-miR-21, hsa-miR-221, and hsa-miR-375)" -tissue_expression_up hsa-mir-17 Glioblastoma 29110584 "Our data demonstrated a significant upregulation of five microRNAs (hsa-miR-16, hsa-miR-17, hsa-miR-21, hsa-miR-221, and hsa-miR-375)" -tissue_expression_up hsa-mir-21 Glioblastoma 29110584 "Our data demonstrated a significant upregulation of five microRNAs (hsa-miR-16, hsa-miR-17, hsa-miR-21, hsa-miR-221, and hsa-miR-375)" -tissue_expression_up hsa-mir-221 Glioblastoma 29110584 "Our data demonstrated a significant upregulation of five microRNAs (hsa-miR-16, hsa-miR-17, hsa-miR-21, hsa-miR-221, and hsa-miR-375)" -tissue_expression_up hsa-mir-375 Glioblastoma 29110584 "Our data demonstrated a significant upregulation of five microRNAs (hsa-miR-16, hsa-miR-17, hsa-miR-21, hsa-miR-221, and hsa-miR-375)" -tissue_expression_up hsa-mir-302c Ovarian Germ Cell Cancer 29138809 "Higher expression of miR-373-3p, miR-372-3p and miR-302c-3p and lower expression of miR-199a-5p, miR-214-5p and miR-202-3p were reproducibly observed in malignant OGCTs as compared to benign OGCTs or SCSTs" -tissue_expression_up hsa-mir-372 Ovarian Germ Cell Cancer 29138809 "Higher expression of miR-373-3p, miR-372-3p and miR-302c-3p and lower expression of miR-199a-5p, miR-214-5p and miR-202-3p were reproducibly observed in malignant OGCTs as compared to benign OGCTs or SCSTs" -tissue_expression_up hsa-mir-373 Ovarian Germ Cell Cancer 29138809 "Higher expression of miR-373-3p, miR-372-3p and miR-302c-3p and lower expression of miR-199a-5p, miR-214-5p and miR-202-3p were reproducibly observed in malignant OGCTs as compared to benign OGCTs or SCSTs" -tissue_expression_up hsa-mir-21 Gastric Neoplasms 29142602 there was a higher expression of VEGF and miR-21 in GC tissues compared with that in morphologically adjacent normal tissues whereas PPAR¦Á expression was decreased -tissue_expression_up hsa-mir-143 Myocardial Infarction 29162889 "The expression level of miR-143 in monocytes from STEMI patients compared to healthy controls was increased, whereas the expression of miR-1, -92a, -99a, and -223 was reduced significantly" -tissue_expression_up hsa-mir-10a Pancreatic Neoplasms 29169171 "miR-27a, miR-27b, miR-9, miR10a and miR-10b were up-regulated in PDAC cells compared to HPDE cells" -tissue_expression_up hsa-mir-10b Pancreatic Neoplasms 29169171 "miR-27a, miR-27b, miR-9, miR10a and miR-10b were up-regulated in PDAC cells compared to HPDE cells" -tissue_expression_up hsa-mir-27a Pancreatic Neoplasms 29169171 "miR-27a, miR-27b, miR-9, miR10a and miR-10b were up-regulated in PDAC cells compared to HPDE cells" -tissue_expression_up hsa-mir-27b Pancreatic Neoplasms 29169171 "miR-27a, miR-27b, miR-9, miR10a and miR-10b were up-regulated in PDAC cells compared to HPDE cells" -tissue_expression_up hsa-mir-9 Pancreatic Neoplasms 29169171 "miR-27a, miR-27b, miR-9, miR10a and miR-10b were up-regulated in PDAC cells compared to HPDE cells" -tissue_expression_up hsa-mir-181a Adenosquamous Pancreas Carcinoma 29221165 "Furthermore, lower Ang-1 and Tie-2 transcript levels and higher increases of miR-21-5p, miR27a-3p and miR-181a-5p levels were found in the rarest form of pancreatic carcinoma." -tissue_expression_up hsa-mir-21 Adenosquamous Pancreas Carcinoma 29221165 "Furthermore, lower Ang-1 and Tie-2 transcript levels and higher increases of miR-21-5p, miR27a-3p and miR-181a-5p levels were found in the rarest form of pancreatic carcinoma." -tissue_expression_up hsa-mir-27a Adenosquamous Pancreas Carcinoma 29221165 "Furthermore, lower Ang-1 and Tie-2 transcript levels and higher increases of miR-21-5p, miR27a-3p and miR-181a-5p levels were found in the rarest form of pancreatic carcinoma." -tissue_expression_up hsa-mir-155 Congenital Heart Diseases 29281614 "Mir-486-3p, mir-486-5p, and mir-155-5p increased in patients with cyanotic heart disease compared with those without heart disease" -tissue_expression_up hsa-mir-486 Congenital Heart Diseases 29281614 "Mir-486-3p, mir-486-5p, and mir-155-5p increased in patients with cyanotic heart disease compared with those without heart disease" -tissue_expression_up hsa-mir-10b "Carcinoma, Hepatocellular" 29314614 "miR-1, miR-122, let-7a, and let-7g were downregulated, whereas miR-10b and miR-21 were upregulated in canine HCC" -tissue_expression_up hsa-mir-21 "Carcinoma, Hepatocellular" 29314614 "miR-1, miR-122, let-7a, and let-7g were downregulated, whereas miR-10b and miR-21 were upregulated in canine HCC" -tissue_expression_up hsa-mir-143 NUT Midline Carcinoma 29322795 "All NMCs showed upregulation of miR-9 and downregulation of miR-99a and miR-145 and two cases featured also upregulation of miR-21, miR-143, and miR-484" -tissue_expression_up hsa-mir-21 NUT Midline Carcinoma 29322795 "All NMCs showed upregulation of miR-9 and downregulation of miR-99a and miR-145 and two cases featured also upregulation of miR-21, miR-143, and miR-484" -tissue_expression_up hsa-mir-484 NUT Midline Carcinoma 29322795 "All NMCs showed upregulation of miR-9 and downregulation of miR-99a and miR-145 and two cases featured also upregulation of miR-21, miR-143, and miR-484" -tissue_expression_up hsa-mir-9 NUT Midline Carcinoma 29322795 "All NMCs showed upregulation of miR-9 and downregulation of miR-99a and miR-145 and two cases featured also upregulation of miR-21, miR-143, and miR-485" -tissue_expression_up hsa-mir-122 Hepatitis C Virus Infection 29359389 "MicroRNAs associated with HCV-related immunopathogenesis which were found to be enriched in exosomes of HCV viremic patients (in particular, miR-122-5p, miR-222-3p, miR-146a, miR-150-5p, miR-30c, miR-378a-3p and miR-20a-5p) were markedly reduced by DAA therapy" -tissue_expression_up hsa-mir-146a Hepatitis C Virus Infection 29359389 "MicroRNAs associated with HCV-related immunopathogenesis which were found to be enriched in exosomes of HCV viremic patients (in particular, miR-122-5p, miR-222-3p, miR-146a, miR-150-5p, miR-30c, miR-378a-3p and miR-20a-5p) were markedly reduced by DAA therapy" -tissue_expression_up hsa-mir-150 Hepatitis C Virus Infection 29359389 "MicroRNAs associated with HCV-related immunopathogenesis which were found to be enriched in exosomes of HCV viremic patients (in particular, miR-122-5p, miR-222-3p, miR-146a, miR-150-5p, miR-30c, miR-378a-3p and miR-20a-5p) were markedly reduced by DAA therapy" -tissue_expression_up hsa-mir-20a Hepatitis C Virus Infection 29359389 "MicroRNAs associated with HCV-related immunopathogenesis which were found to be enriched in exosomes of HCV viremic patients (in particular, miR-122-5p, miR-222-3p, miR-146a, miR-150-5p, miR-30c, miR-378a-3p and miR-20a-5p) were markedly reduced by DAA therapy" -tissue_expression_up hsa-mir-222 Hepatitis C Virus Infection 29359389 "MicroRNAs associated with HCV-related immunopathogenesis which were found to be enriched in exosomes of HCV viremic patients (in particular, miR-122-5p, miR-222-3p, miR-146a, miR-150-5p, miR-30c, miR-378a-3p and miR-20a-5p) were markedly reduced by DAA therapy" -tissue_expression_up hsa-mir-30c Hepatitis C Virus Infection 29359389 "MicroRNAs associated with HCV-related immunopathogenesis which were found to be enriched in exosomes of HCV viremic patients (in particular, miR-122-5p, miR-222-3p, miR-146a, miR-150-5p, miR-30c, miR-378a-3p and miR-20a-5p) were markedly reduced by DAA therapy" -tissue_expression_up hsa-mir-378a Hepatitis C Virus Infection 29359389 "MicroRNAs associated with HCV-related immunopathogenesis which were found to be enriched in exosomes of HCV viremic patients (in particular, miR-122-5p, miR-222-3p, miR-146a, miR-150-5p, miR-30c, miR-378a-3p and miR-20a-5p) were markedly reduced by DAA therapy" -tissue_expression_up hsa-mir-183 "Carcinoma, Thyroid, Medullary" 29388012 Tumour expression levels of miR-21 (p=0.0008) and miR-183 (p=0.0096) were higher in the LNI group -tissue_expression_up hsa-mir-21 "Carcinoma, Thyroid, Medullary" 29388012 Tumour expression levels of miR-21 (p=0.0008) and miR-183 (p=0.0097) were higher in the LNI group -tissue_expression_up hsa-mir-150 Infection [unspecific] 29391047 "upregulated miR-21, miR-155, miR-150, and miR-221, as well as downregulated miR-143 and miR-125, all of them previously linked to other bacterial infections" -tissue_expression_up hsa-mir-155 Infection [unspecific] 29391047 "upregulated miR-21, miR-155, miR-150, and miR-221, as well as downregulated miR-143 and miR-125, all of them previously linked to other bacterial infections" -tissue_expression_up hsa-mir-21 Infection [unspecific] 29391047 "upregulated miR-21, miR-155, miR-150, and miR-221, as well as downregulated miR-143 and miR-125, all of them previously linked to other bacterial infections" -tissue_expression_up hsa-mir-221 Infection [unspecific] 29391047 "upregulated miR-21, miR-155, miR-150, and miR-221, as well as downregulated miR-143 and miR-125, all of them previously linked to other bacterial infections" -tissue_expression_up hsa-mir-142 "Carcinoma, Renal Cell" 29440068 "miR-21, miR-142-3p, miR-142-5p, miR-150, and miR-155 as significantly upregulated" -tissue_expression_up hsa-mir-150 "Carcinoma, Renal Cell" 29440068 "miR-21, miR-142-3p, miR-142-5p, miR-150, and miR-155 as significantly upregulated" -tissue_expression_up hsa-mir-155 "Carcinoma, Renal Cell" 29440068 "miR-21, miR-142-3p, miR-142-5p, miR-150, and miR-155 as significantly upregulated" -tissue_expression_up hsa-mir-21 "Carcinoma, Renal Cell" 29440068 "miR-21, miR-142-3p, miR-142-5p, miR-150, and miR-155 as significantly upregulated" -tissue_expression_up hsa-mir-129-2 "Squamous Cell Carcinoma, Head and Neck" 29455435 two namely Hsa-miR-129-2-3p and Hsa-miR-449a were found to be up-regulated as compared to HPV -ve cells -tissue_expression_up hsa-mir-449a "Squamous Cell Carcinoma, Head and Neck" 29455435 two namely Hsa-miR-129-2-3p and Hsa-miR-449a were found to be up-regulated as compared to HPV -ve cells -tissue_expression_up hsa-let-7b Pleural Mesothelioma 29462963 "They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control" -tissue_expression_up hsa-let-7e Pleural Mesothelioma 29462963 "They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control" -tissue_expression_up hsa-mir-1228 Pleural Mesothelioma 29462963 "They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control" -tissue_expression_up hsa-mir-144 Pleural Mesothelioma 29462963 "They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control" -tissue_expression_up hsa-mir-195 Pleural Mesothelioma 29462963 "They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control" -tissue_expression_up hsa-mir-203 Pleural Mesothelioma 29462963 "They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control" -tissue_expression_up hsa-mir-30b Pleural Mesothelioma 29462963 "They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control" -tissue_expression_up hsa-mir-32 Pleural Mesothelioma 29462963 "They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control" -tissue_expression_up hsa-mir-340 Pleural Mesothelioma 29462963 "They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control" -tissue_expression_up hsa-mir-345 Pleural Mesothelioma 29462963 "They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control" -tissue_expression_up hsa-mir-34a Pleural Mesothelioma 29462963 "They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control" -tissue_expression_up hsa-mir-423 Pleural Mesothelioma 29462963 "They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control" -tissue_expression_up hsa-mir-483 Pleural Mesothelioma 29462963 "They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control" -tissue_expression_up hsa-mir-582 Pleural Mesothelioma 29462963 "They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control" -tissue_expression_up hsa-mir-584 Pleural Mesothelioma 29462963 "They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control" -tissue_expression_up hsa-mir-595 Pleural Mesothelioma 29462963 "They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control" -tissue_expression_up hsa-mir-615 Pleural Mesothelioma 29462963 "They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control" -tissue_expression_up hsa-mir-7-1 Pleural Mesothelioma 29462963 "They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control" -tissue_expression_up hsa-mir-885 Pleural Mesothelioma 29462963 "They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control" -tissue_expression_up hsa-mir-9 Pleural Mesothelioma 29462963 "They reported 12 over-expressed miRNAs (let-7b*, miR-1228*, miR-195*, miR-30b*, miR-32*, miR-345, miR-483-3p, miR-584, miR-595, miR-615-3p, and miR-885-3p) and nine sub-expressed (let-7e*, miR-144*, miR-203, miR-340*, miR-34a*, miR-423, miR-582, miR-7-1* and miR-9) in MPM tissue compared to the single control" -tissue_expression_up hsa-mir-181d "Carcinoma, Adenoid Cystic" 29467480 hsa-miR-455-5p and hsa-miR-181d-5p were upregulated in carcinomas of both salivary and lacrimal gland -tissue_expression_up hsa-mir-455 "Carcinoma, Adenoid Cystic" 29467480 hsa-miR-455-5p and hsa-miR-181d-5p were upregulated in carcinomas of both salivary and lacrimal gland -tissue_expression_up hsa-mir-21 "Squamous Cell Carcinoma, Oral" 29480379 increased miR-21 levels in conjunction with decreased miR-125a levels in saliva of OLP patients may be indicative for a poor prognosis -tissue_expression_up hsa-mir-21 Cervical Neoplasms 29487007 "MiR-21-5p upregulation, miR-34a downregulation, and hTERC amplification were associated with the aggressive progression of CC, which suggests that miR-21-5p, miR-34a and hTERC might serve as surrogate markers for CC progression and potential molecular targets for blockage of the development of CC" -tissue_expression_up hsa-mir-182 Lung Neoplasms 29516903 "the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs" -tissue_expression_up hsa-mir-183 Lung Neoplasms 29516903 "the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs" -tissue_expression_up hsa-mir-200b Lung Neoplasms 29516903 "the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs" -tissue_expression_up hsa-mir-205 Lung Neoplasms 29516903 "the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs" -tissue_expression_up hsa-mir-21 Lung Neoplasms 29516903 "the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs" -tissue_expression_up hsa-mir-210 Lung Neoplasms 29516903 "the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs" -tissue_expression_up hsa-mir-31 Lung Neoplasms 29516903 "the authors identified a statistically significant miRNA meta-signature of seven upregulated (miR-21, miR-210, miR-182, miR-31, miR-200b, miR-205, and miR-183) and eight downregulated (miR-126-3p, miR-30a, miR-30d, miR-486-5p, miR-451a, miR-126-5p, miR-143, and miR-145) miRNAs" -tissue_expression_up hsa-mir-141 Ovarian Neoplasms 29518404 "Specifically, miR-196b, miR-532, miR-886-3b, and miR-99b exhibited lower levels in HGOSC compared with USC, whereas miR-29c, miR-155, miR-454, miR-146b-5p, miR-486-5p, miR-27a, miR-192, and miR-141 exhibited significantly higher expression in HGOSC samples" -tissue_expression_up hsa-mir-146b Ovarian Neoplasms 29518404 "Specifically, miR-196b, miR-532, miR-886-3b, and miR-99b exhibited lower levels in HGOSC compared with USC, whereas miR-29c, miR-155, miR-454, miR-146b-5p, miR-486-5p, miR-27a, miR-192, and miR-141 exhibited significantly higher expression in HGOSC samples" -tissue_expression_up hsa-mir-155 Ovarian Neoplasms 29518404 "Specifically, miR-196b, miR-532, miR-886-3b, and miR-99b exhibited lower levels in HGOSC compared with USC, whereas miR-29c, miR-155, miR-454, miR-146b-5p, miR-486-5p, miR-27a, miR-192, and miR-141 exhibited significantly higher expression in HGOSC samples" -tissue_expression_up hsa-mir-192 Ovarian Neoplasms 29518404 "Specifically, miR-196b, miR-532, miR-886-3b, and miR-99b exhibited lower levels in HGOSC compared with USC, whereas miR-29c, miR-155, miR-454, miR-146b-5p, miR-486-5p, miR-27a, miR-192, and miR-141 exhibited significantly higher expression in HGOSC samples" -tissue_expression_up hsa-mir-27a Ovarian Neoplasms 29518404 "Specifically, miR-196b, miR-532, miR-886-3b, and miR-99b exhibited lower levels in HGOSC compared with USC, whereas miR-29c, miR-155, miR-454, miR-146b-5p, miR-486-5p, miR-27a, miR-192, and miR-141 exhibited significantly higher expression in HGOSC samples" -tissue_expression_up hsa-mir-29c Ovarian Neoplasms 29518404 "Specifically, miR-196b, miR-532, miR-886-3b, and miR-99b exhibited lower levels in HGOSC compared with USC, whereas miR-29c, miR-155, miR-454, miR-146b-5p, miR-486-5p, miR-27a, miR-192, and miR-141 exhibited significantly higher expression in HGOSC samples" -tissue_expression_up hsa-mir-454 Ovarian Neoplasms 29518404 "Specifically, miR-196b, miR-532, miR-886-3b, and miR-99b exhibited lower levels in HGOSC compared with USC, whereas miR-29c, miR-155, miR-454, miR-146b-5p, miR-486-5p, miR-27a, miR-192, and miR-141 exhibited significantly higher expression in HGOSC samples" -tissue_expression_up hsa-mir-486 Ovarian Neoplasms 29518404 "Specifically, miR-196b, miR-532, miR-886-3b, and miR-99b exhibited lower levels in HGOSC compared with USC, whereas miR-29c, miR-155, miR-454, miR-146b-5p, miR-486-5p, miR-27a, miR-192, and miR-141 exhibited significantly higher expression in HGOSC samples" -tissue_expression_up hsa-mir-1246 "Squamous Cell Carcinoma, Oral" 29533734 "Poor prognosis correlated with upregulation of 9 miRNAs (miR-21, miR-455-5p, miiR-155-5p, miR-372, miR-373, miR-29b, miR-1246, miR-196a, and miR-181) and downregulation of 7 miRNAs (miR-204, miR-101, miR-32, miR-20a, miR-16, miR-17, and miR-125b)" -tissue_expression_up hsa-mir-155 "Squamous Cell Carcinoma, Oral" 29533734 "Poor prognosis correlated with upregulation of 9 miRNAs (miR-21, miR-455-5p, miiR-155-5p, miR-372, miR-373, miR-29b, miR-1246, miR-196a, and miR-181) and downregulation of 7 miRNAs (miR-204, miR-101, miR-32, miR-20a, miR-16, miR-17, and miR-125b)" -tissue_expression_up hsa-mir-181 "Squamous Cell Carcinoma, Oral" 29533734 "Poor prognosis correlated with upregulation of 9 miRNAs (miR-21, miR-455-5p, miiR-155-5p, miR-372, miR-373, miR-29b, miR-1246, miR-196a, and miR-181) and downregulation of 7 miRNAs (miR-204, miR-101, miR-32, miR-20a, miR-16, miR-17, and miR-125b)" -tissue_expression_up hsa-mir-196a "Squamous Cell Carcinoma, Oral" 29533734 "Poor prognosis correlated with upregulation of 9 miRNAs (miR-21, miR-455-5p, miiR-155-5p, miR-372, miR-373, miR-29b, miR-1246, miR-196a, and miR-181) and downregulation of 7 miRNAs (miR-204, miR-101, miR-32, miR-20a, miR-16, miR-17, and miR-125b)" -tissue_expression_up hsa-mir-21 "Squamous Cell Carcinoma, Oral" 29533734 "Poor prognosis correlated with upregulation of 9 miRNAs (miR-21, miR-455-5p, miiR-155-5p, miR-372, miR-373, miR-29b, miR-1246, miR-196a, and miR-181) and downregulation of 7 miRNAs (miR-204, miR-101, miR-32, miR-20a, miR-16, miR-17, and miR-125b)" -tissue_expression_up hsa-mir-29b "Squamous Cell Carcinoma, Oral" 29533734 "Poor prognosis correlated with upregulation of 9 miRNAs (miR-21, miR-455-5p, miiR-155-5p, miR-372, miR-373, miR-29b, miR-1246, miR-196a, and miR-181) and downregulation of 7 miRNAs (miR-204, miR-101, miR-32, miR-20a, miR-16, miR-17, and miR-125b)" -tissue_expression_up hsa-mir-372 "Squamous Cell Carcinoma, Oral" 29533734 "Poor prognosis correlated with upregulation of 9 miRNAs (miR-21, miR-455-5p, miiR-155-5p, miR-372, miR-373, miR-29b, miR-1246, miR-196a, and miR-181) and downregulation of 7 miRNAs (miR-204, miR-101, miR-32, miR-20a, miR-16, miR-17, and miR-125b)" -tissue_expression_up hsa-mir-373 "Squamous Cell Carcinoma, Oral" 29533734 "Poor prognosis correlated with upregulation of 9 miRNAs (miR-21, miR-455-5p, miiR-155-5p, miR-372, miR-373, miR-29b, miR-1246, miR-196a, and miR-181) and downregulation of 7 miRNAs (miR-204, miR-101, miR-32, miR-20a, miR-16, miR-17, and miR-125b)" -tissue_expression_up hsa-mir-455 "Squamous Cell Carcinoma, Oral" 29533734 "Poor prognosis correlated with upregulation of 9 miRNAs (miR-21, miR-455-5p, miiR-155-5p, miR-372, miR-373, miR-29b, miR-1246, miR-196a, and miR-181) and downregulation of 7 miRNAs (miR-204, miR-101, miR-32, miR-20a, miR-16, miR-17, and miR-125b)" -tissue_expression_up hsa-mir-125b Glioblastoma 29538610 "Upregulation of miR-125b, miR-181d, and miR-221 Predicts Poor Prognosis in MGMT Promoter-Unmethylated Glioblastoma Patients" -tissue_expression_up hsa-mir-181d Glioblastoma 29538610 "Upregulation of miR-125b, miR-181d, and miR-221 Predicts Poor Prognosis in MGMT Promoter-Unmethylated Glioblastoma Patients" -tissue_expression_up hsa-mir-221 Glioblastoma 29538610 "Upregulation of miR-125b, miR-181d, and miR-221 Predicts Poor Prognosis in MGMT Promoter-Unmethylated Glioblastoma Patients" -tissue_expression_up hsa-mir-320 Osteonecrosis 29551500 Upregulation of microRNA-320 decreases the risk of developing steroid-induced avascular necrosis of femoral head by inhibiting CYP1A2 both in vivo and in vitro. -tissue_expression_up hsa-mir-21 Glioblastoma 29559295 "In our microarray data, lower expression of miR-219-5p, miR-124, and miR-128 and higher expression of miR-21 was observed in GBM compared with the peripheral region, similar to the results of previous reports" -tissue_expression_up hsa-mir-155 "Scleroderma, Systemic" 29559981 "miR-21-5p, miR-92a-3p, miR-155-5p, and miR-16-5p expression was significantly higher in SSc sera compared to healthy controls" -tissue_expression_up hsa-mir-16 "Scleroderma, Systemic" 29559981 "miR-21-5p, miR-92a-3p, miR-155-5p, and miR-16-5p expression was significantly higher in SSc sera compared to healthy controls" -tissue_expression_up hsa-mir-21 "Scleroderma, Systemic" 29559981 "miR-21-5p, miR-92a-3p, miR-155-5p, and miR-16-5p expression was significantly higher in SSc sera compared to healthy controls" -tissue_expression_up hsa-mir-92a "Scleroderma, Systemic" 29559981 "miR-21-5p, miR-92a-3p, miR-155-5p, and miR-16-5p expression was significantly higher in SSc sera compared to healthy controls" -tissue_expression_up hsa-mir-127 Prostate Neoplasms 29568403 "The top 11 miRNAs with significantly higher level in ExoHypoxic compared to ExoNormoxic were miR-517a, miR-204, miR-885, miR-143, miR-335, miR-127, miR-542, miR-433, miR-451, miR-92a and miR-186a" -tissue_expression_up hsa-mir-143 Prostate Neoplasms 29568403 "The top 11 miRNAs with significantly higher level in ExoHypoxic compared to ExoNormoxic were miR-517a, miR-204, miR-885, miR-143, miR-335, miR-127, miR-542, miR-433, miR-451, miR-92a and miR-184a" -tissue_expression_up hsa-mir-181a Prostate Neoplasms 29568403 "The top 11 miRNAs with significantly higher level in ExoHypoxic compared to ExoNormoxic were miR-517a, miR-204, miR-885, miR-143, miR-335, miR-127, miR-542, miR-433, miR-451, miR-92a and miR-191a" -tissue_expression_up hsa-mir-204 Prostate Neoplasms 29568403 "The top 11 miRNAs with significantly higher level in ExoHypoxic compared to ExoNormoxic were miR-517a, miR-204, miR-885, miR-143, miR-335, miR-127, miR-542, miR-433, miR-451, miR-92a and miR-182a" -tissue_expression_up hsa-mir-335 Prostate Neoplasms 29568403 "The top 11 miRNAs with significantly higher level in ExoHypoxic compared to ExoNormoxic were miR-517a, miR-204, miR-885, miR-143, miR-335, miR-127, miR-542, miR-433, miR-451, miR-92a and miR-185a" -tissue_expression_up hsa-mir-433 Prostate Neoplasms 29568403 "The top 11 miRNAs with significantly higher level in ExoHypoxic compared to ExoNormoxic were miR-517a, miR-204, miR-885, miR-143, miR-335, miR-127, miR-542, miR-433, miR-451, miR-92a and miR-188a" -tissue_expression_up hsa-mir-451 Prostate Neoplasms 29568403 "The top 11 miRNAs with significantly higher level in ExoHypoxic compared to ExoNormoxic were miR-517a, miR-204, miR-885, miR-143, miR-335, miR-127, miR-542, miR-433, miR-451, miR-92a and miR-189a" -tissue_expression_up hsa-mir-517a Prostate Neoplasms 29568403 "The top 11 miRNAs with significantly higher level in ExoHypoxic compared to ExoNormoxic were miR-517a, miR-204, miR-885, miR-143, miR-335, miR-127, miR-542, miR-433, miR-451, miR-92a and miR-181a" -tissue_expression_up hsa-mir-542 Prostate Neoplasms 29568403 "The top 11 miRNAs with significantly higher level in ExoHypoxic compared to ExoNormoxic were miR-517a, miR-204, miR-885, miR-143, miR-335, miR-127, miR-542, miR-433, miR-451, miR-92a and miR-187a" -tissue_expression_up hsa-mir-885 Prostate Neoplasms 29568403 "The top 11 miRNAs with significantly higher level in ExoHypoxic compared to ExoNormoxic were miR-517a, miR-204, miR-885, miR-143, miR-335, miR-127, miR-542, miR-433, miR-451, miR-92a and miR-183a" -tissue_expression_up hsa-mir-92a Prostate Neoplasms 29568403 "The top 11 miRNAs with significantly higher level in ExoHypoxic compared to ExoNormoxic were miR-517a, miR-204, miR-885, miR-143, miR-335, miR-127, miR-542, miR-433, miR-451, miR-92a and miR-190a" -tissue_expression_up hsa-mir-145 "Carcinoma, Ovarian" 29569698 miRNA-145 expression was lower in DPEEOC endometrial tissues and higher in DPEEOC ovarian tissues compared to the corresponding normal tissues -tissue_expression_up hsa-mir-373 "Squamous Cell Carcinoma, Esophageal" 29578163 "Upregulation of miR-371-373 cluster, a human embryonic stem cell specific microRNA cluster, in esophageal squamous cell carcinoma" -tissue_expression_up hsa-let-7a Pancreatic Neoplasms 29596326 These effects were associated with increases in the expression of let-7a microRNA; suppression of K-Ras and survivin; and the elimination of drug-resistant cancer stem/tumor-initiating cells -tissue_expression_up hsa-mir-20a Breast Neoplasms 29617404 "Our results suggest a role for miR-20a in the regulation of breast cancer angiogenesis, and raise the possibility of its use as an angiogenic biomarker" -tissue_expression_up hsa-mir-10a Urinary System Cancer 29623292 the decline of miR-145 expression level have been proved to be able to distinguish bladder cancer patients from non-cancer controls in cell-free urine samples5; the elevation of miR-10a and miR-30d was also observed in urine samples from patients with focal segmental glomerulosclerosis -tissue_expression_up hsa-mir-30d Urinary System Cancer 29623292 the decline of miR-145 expression level have been proved to be able to distinguish bladder cancer patients from non-cancer controls in cell-free urine samples5; the elevation of miR-10a and miR-30d was also observed in urine samples from patients with focal segmental glomerulosclerosis -tissue_expression_up hsa-mir-155 Atherosclerosis 29642385 Exposure to the high dose of CS also significantly upregulated the miRNA-155 level in the aortic tissues of ApoE KO mice -tissue_expression_up hsa-mir-155 Myocardial Infarction 29642385 Exposure to the high dose of CS also significantly upregulated the miRNA-155 level in the aortic tissues of ApoE KO mice -tissue_expression_up hsa-mir-155 Stroke 29642385 Exposure to the high dose of CS also significantly upregulated the miRNA-155 level in the aortic tissues of ApoE KO mice -tissue_expression_up hsa-mir-21 Atherosclerosis 29642385 "Moreover, the expression level of miR-126 tended to be downregulated and that of miR-21 tended to be upregulated in ApoE KO mice exposed to the high dose of CS, albeit statistically insignificant" -tissue_expression_up hsa-mir-21 Myocardial Infarction 29642385 "Moreover, the expression level of miR-126 tended to be downregulated and that of miR-21 tended to be upregulated in ApoE KO mice exposed to the high dose of CS, albeit statistically insignificant" -tissue_expression_up hsa-mir-21 Stroke 29642385 "Moreover, the expression level of miR-126 tended to be downregulated and that of miR-21 tended to be upregulated in ApoE KO mice exposed to the high dose of CS, albeit statistically insignificant" -tissue_expression_up hsa-mir-101 Medulloblastoma 29658967 "Low-expression of miR-221, miR-9, and miR-181c/d and over-expression of miR-101, miR-222, miR-139, miR-1827, and miR-34c was found in medulloblastoma" -tissue_expression_up hsa-mir-10b Ependymoma 29658967 low expression of miR-10a and over-expression of miR-10b and miR-29a in ependymoma -tissue_expression_up hsa-mir-139 Medulloblastoma 29658967 "Low-expression of miR-221, miR-9, and miR-181c/d and over-expression of miR-101, miR-222, miR-139, miR-1827, and miR-34c was found in medulloblastoma" -tissue_expression_up hsa-mir-1827 Medulloblastoma 29658967 "Low-expression of miR-221, miR-9, and miR-181c/d and over-expression of miR-101, miR-222, miR-139, miR-1827, and miR-34c was found in medulloblastoma" -tissue_expression_up hsa-mir-19a Glioma 29658967 "low expression of miR-26a and overexpression of miR-19a/b, miR-24, miR-27a, miR- 584, and miR-528 in low-grade glioma" -tissue_expression_up hsa-mir-19b Glioma 29658967 "low expression of miR-26a and overexpression of miR-19a/b, miR-24, miR-27a, miR- 584, and miR-529 in low-grade glioma" -tissue_expression_up hsa-mir-222 Medulloblastoma 29658967 "Low-expression of miR-221, miR-9, and miR-181c/d and over-expression of miR-101, miR-222, miR-139, miR-1827, and miR-34c was found in medulloblastoma" -tissue_expression_up hsa-mir-24 Glioma 29658967 "low expression of miR-26a and overexpression of miR-19a/b, miR-24, miR-27a, miR- 584, and miR-530 in low-grade glioma" -tissue_expression_up hsa-mir-27a Glioma 29658967 "low expression of miR-26a and overexpression of miR-19a/b, miR-24, miR-27a, miR- 584, and miR-531 in low-grade glioma" -tissue_expression_up hsa-mir-29a Ependymoma 29658967 low expression of miR-10a and over-expression of miR-10b and miR-29a in ependymoma -tissue_expression_up hsa-mir-34c Medulloblastoma 29658967 "Low-expression of miR-221, miR-9, and miR-181c/d and over-expression of miR-101, miR-222, miR-139, miR-1827, and miR-34c was found in medulloblastoma" -tissue_expression_up hsa-mir-527 Glioma 29658967 "low expression of miR-26a and overexpression of miR-19a/b, miR-24, miR-27a, miR- 584, and miR-533 in low-grade glioma" -tissue_expression_up hsa-mir-584 Glioma 29658967 "low expression of miR-26a and overexpression of miR-19a/b, miR-24, miR-27a, miR- 584, and miR-532 in low-grade glioma" -tissue_expression_up hsa-mir-155 Down Syndrome 29661714 microRNA 155 up regulation in the CNS is strongly correlated to Down's syndrome dementia. -tissue_expression_up hsa-mir-124 Non Specific Chronic Endometritis 29663566 "MiR-27a-3p and miR-124-3p, upregulated in endometrium and serum from women affected by Chronic Endometritis, are new potential molecular markers of endometrial receptivity." -tissue_expression_up hsa-mir-27a Non Specific Chronic Endometritis 29663566 "MiR-27a-3p and miR-124-3p, upregulated in endometrium and serum from women affected by Chronic Endometritis, are new potential molecular markers of endometrial receptivity." -tissue_expression_up hsa-mir-125b "Squamous Cell Carcinoma, Head and Neck" 29667275 "miR-26 and miR-125b may be associated with the progression and metastasis of HNSCC, and that miR-203 is associated with a more favourable prognosis." -tissue_expression_up hsa-mir-26 "Squamous Cell Carcinoma, Head and Neck" 29667275 "miR-26 and miR-125b may be associated with the progression and metastasis of HNSCC, and that miR-203 is associated with a more favourable prognosis." -tissue_expression_up hsa-mir-375 "Carcinoma, Thyroid, Follicular" 29683529 High expression values of MirR-375 provided 100% ROM -tissue_expression_up hsa-mir-133a "Carcinoma, Breast" 29698983 high responders exhibited increased miR-133a-3p and a borderline statistically significant increase in miR-370-3p -tissue_expression_up hsa-mir-370a "Carcinoma, Breast" 29698983 high responders exhibited increased miR-133a-3p and a borderline statistically significant increase in miR-370-3p -tissue_expression_up hsa-mir-18a Osteonecrosis 29700584 Bioinformatics genetic network analysis focusing on the six miRNAs found the upregulated miR-18a and miR-19a are associated with angiogenesis after induction of ischemia -tissue_expression_up hsa-mir-19a Osteonecrosis 29700584 Bioinformatics genetic network analysis focusing on the six miRNAs found the upregulated miR-18a and miR-19a are associated with angiogenesis after induction of ischemia -tissue_expression_up hsa-mir-21 "Adenocarcinoma, Ampullary" 29731265 MiR-21 up-regulation in ampullary adenocarcinoma and its pre-invasive lesions. -tissue_expression_up hsa-mir-467d Alcoholic Cardiomyopathy 29734191 The results demonstrated that miR-467d-3p and miR-491-5p were up-regulated and miR-3098-3p was down-regulated in the alcohol-exposed myocardial samples compared with the control samples (P < 0.05). -tissue_expression_up hsa-mir-491 Alcoholic Cardiomyopathy 29734191 The results demonstrated that miR-467d-3p and miR-491-5p were up-regulated and miR-3098-3p was down-regulated in the alcohol-exposed myocardial samples compared with the control samples (P < 0.05). -tissue_expression_up hsa-mir-223 "Carcinoma, Cervical" 29737570 the low expression of miR-188 and high expression of miR-223 correlated with the short survival of CC patients -tissue_expression_up hsa-mir-92b Cholangiocarcinoma 29749758 The high level of miR-92b was associated with adverse outcomes in cholangiocarcinoma patients -tissue_expression_up hsa-mir-203 "Carcinoma, Breast" 29750301 Sevoflurane suppresses proliferation by upregulating microRNA-203 in breast cancer cells. -tissue_expression_up hsa-mir-140 Fatty Liver [unspecific] 29751019 "the expression of Rev-erb¦Á-targeting miRNAs, miR-140-5p, 185-5p, 326-5p and 328-5p were increased in this group." -tissue_expression_up hsa-mir-185 Fatty Liver [unspecific] 29751019 "the expression of Rev-erb¦Á-targeting miRNAs, miR-140-5p, 185-5p, 326-5p and 328-5p were increased in this group." -tissue_expression_up hsa-mir-326 Fatty Liver [unspecific] 29751019 "the expression of Rev-erb¦Á-targeting miRNAs, miR-140-5p, 185-5p, 326-5p and 328-5p were increased in this group." -tissue_expression_up hsa-mir-328 Fatty Liver [unspecific] 29751019 "the expression of Rev-erb¦Á-targeting miRNAs, miR-140-5p, 185-5p, 326-5p and 328-5p were increased in this group." -tissue_expression_up hsa-mir-139 Chronic Obstructive Pulmonary Disease 29757677 "expression levels of miR-98, miR-139-5p, miR-146b-5p, and miR-451 were upregulated, as compared with NS. In contrast, miR-197, miR-204, miR-485-3p, and miR-627 were downregulated." -tissue_expression_up hsa-mir-146b Chronic Obstructive Pulmonary Disease 29757677 "expression levels of miR-98, miR-139-5p, miR-146b-5p, and miR-451 were upregulated, as compared with NS. In contrast, miR-197, miR-204, miR-485-3p, and miR-627 were downregulated." -tissue_expression_up hsa-mir-451 Chronic Obstructive Pulmonary Disease 29757677 "expression levels of miR-98, miR-139-5p, miR-146b-5p, and miR-451 were upregulated, as compared with NS. In contrast, miR-197, miR-204, miR-485-3p, and miR-627 were downregulated." -tissue_expression_up hsa-mir-98 Chronic Obstructive Pulmonary Disease 29757677 "expression levels of miR-98, miR-139-5p, miR-146b-5p, and miR-451 were upregulated, as compared with NS. In contrast, miR-197, miR-204, miR-485-3p, and miR-627 were downregulated." -tissue_expression_up hsa-mir-21 "Squamous Cell Carcinoma, Oral" 29764807 "Upregulation of miR-31 and miR-21 and downregulation of miR-99a, let-7c, miR-125b, and miR-100 were found between OSCC and controls" -tissue_expression_up hsa-mir-31 "Squamous Cell Carcinoma, Oral" 29764807 "Upregulation of miR-31 and miR-21 and downregulation of miR-99a, let-7c, miR-125b, and miR-100 were found between OSCC and controls" -tissue_expression_up hsa-mir-3666 Colorectal Carcinoma 29772445 The protective role of all-transretinoic acid (ATRA) against colorectal cancer development is achieved via increasing miR-3666 expression and decreasing E2F7 expression. -tissue_expression_up hsa-mir-19 Gastric Neoplasms 29797599 "Our data showed that miR-146, miR-375, and Let-7 were down-regulated and miR-19 and miR-21 were up-regulated in GC patients with H. pylori infection" -tissue_expression_up hsa-mir-21 Gastric Neoplasms 29797599 "Our data showed that miR-146, miR-375, and Let-7 were down-regulated and miR-19 and miR-21 were up-regulated in GC patients with H. pylori infection" -tissue_expression_up hsa-mir-451 Placenta Cancer 29805755 "The results showed that miR-451 and miR-720, highly expressed placental miRNAs, presented very low or undetectable expression in cancer cell lines compared to the normal placenta and healthy tissues" -tissue_expression_up hsa-mir-720 Placenta Cancer 29805755 "The results showed that miR-451 and miR-720, highly expressed placental miRNAs, presented very low or undetectable expression in cancer cell lines compared to the normal placenta and healthy tissues" -tissue_expression_up hsa-let-7a "Adenocarcinoma, Lung" 29806739 miR-126 (P < 0.001) and Let-7a (P = 0.015) levels were significantly higher in the BAL fluid of lung adenocarcinoma patients than in control subjects -tissue_expression_up hsa-mir-126 "Adenocarcinoma, Lung" 29806739 miR-126 (P < 0.001) and Let-7a (P = 0.015) levels were significantly higher in the BAL fluid of lung adenocarcinoma patients than in control subjects -tissue_expression_up hsa-mir-324 Lung Neoplasms 29844840 The data revealed that miR-324-5p and -3p were significantly overexpressed in lung cancer cells -tissue_expression_up hsa-mir-106b Gastric Neoplasms 29859516 "Up-Regulation of miR-21, miR-25, miR-93, and miR-106b in Gastric Cancer" -tissue_expression_up hsa-mir-21 Gastric Neoplasms 29859516 "Up-Regulation of miR-21, miR-25, miR-93, and miR-106b in Gastric Cancer" -tissue_expression_up hsa-mir-25 Gastric Neoplasms 29859516 "Up-Regulation of miR-21, miR-25, miR-93, and miR-106b in Gastric Cancer" -tissue_expression_up hsa-mir-93 Gastric Neoplasms 29859516 "Up-Regulation of miR-21, miR-25, miR-93, and miR-106b in Gastric Cancer" -tissue_expression_up hsa-mir-17 Colorectal Carcinoma 29902577 Early metastatic colorectal cancers show increased tissue expression of miR-17/92 cluster members in the invasive tumor front. -tissue_expression_up hsa-mir-18 Colorectal Carcinoma 29902577 Early metastatic colorectal cancers show increased tissue expression of miR-17/92 cluster members in the invasive tumor front. -tissue_expression_up hsa-mir-19a Colorectal Carcinoma 29902577 Early metastatic colorectal cancers show increased tissue expression of miR-17/92 cluster members in the invasive tumor front. -tissue_expression_up hsa-mir-19b-1 Colorectal Carcinoma 29902577 Early metastatic colorectal cancers show increased tissue expression of miR-17/92 cluster members in the invasive tumor front. -tissue_expression_up hsa-mir-20a Colorectal Carcinoma 29902577 Early metastatic colorectal cancers show increased tissue expression of miR-17/92 cluster members in the invasive tumor front. -tissue_expression_up hsa-mir-92-1 Colorectal Carcinoma 29902577 Early metastatic colorectal cancers show increased tissue expression of miR-17/92 cluster members in the invasive tumor front. -tissue_expression_up hsa-mir-192 Barrett Esophagus 29906417 "The miRNAs with the greatest increases in BE tissues (7.9-fold increase in expression or more, P < .0001: MIR196a, MIR192, MIR194, and MIR215) each identified BE vs control tissues" -tissue_expression_up hsa-mir-194 Barrett Esophagus 29906417 "The miRNAs with the greatest increases in BE tissues (7.9-fold increase in expression or more, P < .0001: MIR196a, MIR192, MIR194, and MIR215) each identified BE vs control tissues" -tissue_expression_up hsa-mir-196a Barrett Esophagus 29906417 "The miRNAs with the greatest increases in BE tissues (7.9-fold increase in expression or more, P < .0001: MIR196a, MIR192, MIR194, and MIR215) each identified BE vs control tissues" -tissue_expression_up hsa-mir-215 Barrett Esophagus 29906417 "The miRNAs with the greatest increases in BE tissues (7.9-fold increase in expression or more, P < .0001: MIR196a, MIR192, MIR194, and MIR215) each identified BE vs control tissues" -tissue_expression_up hsa-mir-142 Chronic Kidney Disease 29909697 "We recognized in both meta-analysis approaches a significant miRNA meta-signature of five up-regulated (miR-142-3p, miR-223-3p, miR-21-5p, miR-142-5p and miR-214-3p) and two down-regulated (miR-29c-3p and miR-200a-3p) miRNAs" -tissue_expression_up hsa-mir-21 Chronic Kidney Disease 29909697 "We recognized in both meta-analysis approaches a significant miRNA meta-signature of five up-regulated (miR-142-3p, miR-223-3p, miR-21-5p, miR-142-5p and miR-214-3p) and two down-regulated (miR-29c-3p and miR-200a-3p) miRNAs" -tissue_expression_up hsa-mir-214 Chronic Kidney Disease 29909697 "We recognized in both meta-analysis approaches a significant miRNA meta-signature of five up-regulated (miR-142-3p, miR-223-3p, miR-21-5p, miR-142-5p and miR-214-3p) and two down-regulated (miR-29c-3p and miR-200a-3p) miRNAs" -tissue_expression_up hsa-mir-223 Chronic Kidney Disease 29909697 "We recognized in both meta-analysis approaches a significant miRNA meta-signature of five up-regulated (miR-142-3p, miR-223-3p, miR-21-5p, miR-142-5p and miR-214-3p) and two down-regulated (miR-29c-3p and miR-200a-3p) miRNAs" -tissue_expression_up hsa-mir-10b "Carcinoma, Breast, Triple Negative" 29923083 "(1) upregulated: miR-10b, miR-21, miR-29, miR-9, miR-221/222, miR-373 or (2) downregulated: miR-145, miR-199a-5p, miR-200 family, miR-203, miR-205 in TNBC" -tissue_expression_up hsa-mir-21 "Carcinoma, Breast, Triple Negative" 29923083 "(1) upregulated: miR-10b, miR-21, miR-29, miR-9, miR-221/222, miR-373 or (2) downregulated: miR-145, miR-199a-5p, miR-200 family, miR-203, miR-205 in TNBC" -tissue_expression_up hsa-mir-221 "Carcinoma, Breast, Triple Negative" 29923083 "(1) upregulated: miR-10b, miR-21, miR-29, miR-9, miR-221/222, miR-373 or (2) downregulated: miR-145, miR-199a-5p, miR-200 family, miR-203, miR-205 in TNBC" -tissue_expression_up hsa-mir-222 "Carcinoma, Breast, Triple Negative" 29923083 "(1) upregulated: miR-10b, miR-21, miR-29, miR-9, miR-221/222, miR-373 or (2) downregulated: miR-145, miR-199a-5p, miR-200 family, miR-203, miR-205 in TNBC" -tissue_expression_up hsa-mir-29 "Carcinoma, Breast, Triple Negative" 29923083 "(1) upregulated: miR-10b, miR-21, miR-29, miR-9, miR-221/222, miR-373 or (2) downregulated: miR-145, miR-199a-5p, miR-200 family, miR-203, miR-205 in TNBC" -tissue_expression_up hsa-mir-373 "Carcinoma, Breast, Triple Negative" 29923083 "(1) upregulated: miR-10b, miR-21, miR-29, miR-9, miR-221/222, miR-373 or (2) downregulated: miR-145, miR-199a-5p, miR-200 family, miR-203, miR-205 in TNBC" -tissue_expression_up hsa-mir-9 "Carcinoma, Breast, Triple Negative" 29923083 "(1) upregulated: miR-10b, miR-21, miR-29, miR-9, miR-221/222, miR-373 or (2) downregulated: miR-145, miR-199a-5p, miR-200 family, miR-203, miR-205 in TNBC" -tissue_expression_up hsa-mir-210 Neuroendocrine Tumors 29983867 "NEN metastases were associated with elevated levels of miR-30a-5p, miR-210, miR-339-3p, miR-345 and miR-660" -tissue_expression_up hsa-mir-30a Neuroendocrine Tumors 29983867 "NEN metastases were associated with elevated levels of miR-30a-5p, miR-210, miR-339-3p, miR-345 and miR-660" -tissue_expression_up hsa-mir-339 Neuroendocrine Tumors 29983867 "NEN metastases were associated with elevated levels of miR-30a-5p, miR-210, miR-339-3p, miR-345 and miR-660" -tissue_expression_up hsa-mir-345 Neuroendocrine Tumors 29983867 "NEN metastases were associated with elevated levels of miR-30a-5p, miR-210, miR-339-3p, miR-345 and miR-660" -tissue_expression_up hsa-mir-660 Neuroendocrine Tumors 29983867 "NEN metastases were associated with elevated levels of miR-30a-5p, miR-210, miR-339-3p, miR-345 and miR-660" -tissue_expression_up hsa-mir-146b Glioblastoma 30018734 The immune-related microRNA miR-146b is upregulated in glioblastoma recurrence. -tissue_expression_up hsa-mir-21 Lung Neoplasms 30030592 Overview upon miR-21 in lung cancer: focus on NSCLC. -tissue_expression_up hsa-mir-192 "Carcinoma, Ovarian" 30038317 The microRNA miR-192/215 family is upregulated in mucinous ovarian carcinomas. -tissue_expression_up hsa-mir-215 "Carcinoma, Ovarian" 30038317 The microRNA miR-192/215 family is upregulated in mucinous ovarian carcinomas. -tissue_expression_up hsa-mir-126 Cholangiocarcinoma 30042823 "High miR-126, low miR-128 and TEMs were independent prognostic factors for recurrence-free and overall survival" -tissue_expression_up hsa-mir-515 "Carcinoma, Hepatocellular" 30052636 "HCC had significantly higher expression of members of the chromosome 19 miRNA cluster (C19MC), including miR-515-5p, miR-517a, miR-518b, and miR-520c-3p" -tissue_expression_up hsa-mir-517a "Carcinoma, Hepatocellular" 30052636 "HCC had significantly higher expression of members of the chromosome 19 miRNA cluster (C19MC), including miR-515-5p, miR-517a, miR-518b, and miR-520c-3p" -tissue_expression_up hsa-mir-518b "Carcinoma, Hepatocellular" 30052636 "HCC had significantly higher expression of members of the chromosome 19 miRNA cluster (C19MC), including miR-515-5p, miR-517a, miR-518b, and miR-520c-3p" -tissue_expression_up hsa-mir-520c "Carcinoma, Hepatocellular" 30052636 "HCC had significantly higher expression of members of the chromosome 19 miRNA cluster (C19MC), including miR-515-5p, miR-517a, miR-518b, and miR-520c-3p" -tissue_expression_up hsa-mir-372 "Adenocarcinoma, Lung" 30066858 "the predicted miRNA, miR-372-3p, exhibited a high expression in both the NSCLC and LUAD tissues" -tissue_expression_up hsa-mir-372 "Carcinoma, Lung, Non-Small-Cell" 30066858 "the predicted miRNA, miR-372-3p, exhibited a high expression in both the NSCLC and LUAD tissues" -tissue_expression_up hsa-mir-141 Neoplasms [unspecific] 30069274 Correlation between miR-200 Family Overexpression and Cancer Prognosis. -tissue_expression_up hsa-mir-200a Neoplasms [unspecific] 30069274 Correlation between miR-200 Family Overexpression and Cancer Prognosis. -tissue_expression_up hsa-mir-200b Neoplasms [unspecific] 30069274 Correlation between miR-200 Family Overexpression and Cancer Prognosis. -tissue_expression_up hsa-mir-200c Neoplasms [unspecific] 30069274 Correlation between miR-200 Family Overexpression and Cancer Prognosis. -tissue_expression_up hsa-mir-429 Neoplasms [unspecific] 30069274 Correlation between miR-200 Family Overexpression and Cancer Prognosis. -tissue_expression_up hsa-mir-152 "Carcinoma, Adenoid Cystic" 30069755 "qPCR identified high expression of hsa-mir-21, hsa-mir-181a-2, and hsa-mir-152 to be associated with reduced OS and high expression of hsa-miR-374c to be associated with improved RFS" -tissue_expression_up hsa-mir-181a "Carcinoma, Adenoid Cystic" 30069755 "qPCR identified high expression of hsa-mir-21, hsa-mir-181a-2, and hsa-mir-152 to be associated with reduced OS and high expression of hsa-miR-374c to be associated with improved RFS" -tissue_expression_up hsa-mir-21 "Carcinoma, Adenoid Cystic" 30069755 "qPCR identified high expression of hsa-mir-21, hsa-mir-181a-2, and hsa-mir-152 to be associated with reduced OS and high expression of hsa-miR-374c to be associated with improved RFS" -tissue_expression_up hsa-mir-374c "Carcinoma, Adenoid Cystic" 30069755 "qPCR identified high expression of hsa-mir-21, hsa-mir-181a-2, and hsa-mir-152 to be associated with reduced OS and high expression of hsa-miR-374c to be associated with improved RFS" -tissue_expression_up hsa-mir-122 Liver Injury 30087537 "In liver injury, the levels of miR-122-5p, miR-192-5p, miR-223-3p, and miR-1224-5p were reported to be elevated in the sera" -tissue_expression_up hsa-mir-1224 Liver Injury 30087537 "In liver injury, the levels of miR-122-5p, miR-192-5p, miR-223-3p, and miR-1224-5p were reported to be elevated in the sera" -tissue_expression_up hsa-mir-192 Liver Injury 30087537 "In liver injury, the levels of miR-122-5p, miR-192-5p, miR-223-3p, and miR-1224-5p were reported to be elevated in the sera" -tissue_expression_up hsa-mir-223 Liver Injury 30087537 "In liver injury, the levels of miR-122-5p, miR-192-5p, miR-223-3p, and miR-1224-5p were reported to be elevated in the sera" -tissue_expression_up hsa-mir-112 Astrocytoma 30090984 "we found the upregulation of miR-210-3p, miR-155-5p, miR-UL-112-3p, miR-183-5p, and miR-223-5p in high-grade astrocytic tumors as compared with low-grade tumor tissues" -tissue_expression_up hsa-mir-155 Astrocytoma 30090984 "we found the upregulation of miR-210-3p, miR-155-5p, miR-UL-112-3p, miR-183-5p, and miR-223-5p in high-grade astrocytic tumors as compared with low-grade tumor tissues" -tissue_expression_up hsa-mir-183 Astrocytoma 30090984 "we found the upregulation of miR-210-3p, miR-155-5p, miR-UL-112-3p, miR-183-5p, and miR-223-5p in high-grade astrocytic tumors as compared with low-grade tumor tissues" -tissue_expression_up hsa-mir-210 Astrocytoma 30090984 "we found the upregulation of miR-210-3p, miR-155-5p, miR-UL-112-3p, miR-183-5p, and miR-223-5p in high-grade astrocytic tumors as compared with low-grade tumor tissues" -tissue_expression_up hsa-mir-223 Astrocytoma 30090984 "we found the upregulation of miR-210-3p, miR-155-5p, miR-UL-112-3p, miR-183-5p, and miR-223-5p in high-grade astrocytic tumors as compared with low-grade tumor tissues" -tissue_expression_up hsa-mir-100 Ovarian Neoplasms 30107086 "We report that miR-21 (P?=?0.0001), miR-100 (P?=?0.034), miR-200b (P?=?0.008), and miR-320 (P?=?0.034) are significantly enriched, whereas miR-16 (P?=?0.009), miR-93 (P?=?0.014), miR-126 (P?=?0.012), and miR-223 (P?=?0.029) are underrepresented in exosomes from plasma of EOC patients as compared to those of healthy women. The levels of exosomal miR-23a (P?=?0.009, 0.008) and miR-92a (P?=?009, 0.034) were lower in ovarian cystadenoma patients than in EOC patients and healthy women, respectively" -tissue_expression_up hsa-mir-200b Ovarian Neoplasms 30107086 "We report that miR-21 (P?=?0.0001), miR-100 (P?=?0.034), miR-200b (P?=?0.008), and miR-320 (P?=?0.034) are significantly enriched, whereas miR-16 (P?=?0.009), miR-93 (P?=?0.014), miR-126 (P?=?0.012), and miR-223 (P?=?0.029) are underrepresented in exosomes from plasma of EOC patients as compared to those of healthy women. The levels of exosomal miR-23a (P?=?0.009, 0.008) and miR-92a (P?=?009, 0.034) were lower in ovarian cystadenoma patients than in EOC patients and healthy women, respectively" -tissue_expression_up hsa-mir-21 Ovarian Neoplasms 30107086 "We report that miR-21 (P?=?0.0001), miR-100 (P?=?0.034), miR-200b (P?=?0.008), and miR-320 (P?=?0.034) are significantly enriched, whereas miR-16 (P?=?0.009), miR-93 (P?=?0.014), miR-126 (P?=?0.012), and miR-223 (P?=?0.029) are underrepresented in exosomes from plasma of EOC patients as compared to those of healthy women. The levels of exosomal miR-23a (P?=?0.009, 0.008) and miR-92a (P?=?009, 0.034) were lower in ovarian cystadenoma patients than in EOC patients and healthy women, respectively" -tissue_expression_up hsa-mir-320 Ovarian Neoplasms 30107086 "We report that miR-21 (P?=?0.0001), miR-100 (P?=?0.034), miR-200b (P?=?0.008), and miR-320 (P?=?0.034) are significantly enriched, whereas miR-16 (P?=?0.009), miR-93 (P?=?0.014), miR-126 (P?=?0.012), and miR-223 (P?=?0.029) are underrepresented in exosomes from plasma of EOC patients as compared to those of healthy women. The levels of exosomal miR-23a (P?=?0.009, 0.008) and miR-92a (P?=?009, 0.034) were lower in ovarian cystadenoma patients than in EOC patients and healthy women, respectively" -tissue_expression_up hsa-mir-210 Prostate Neoplasms 30109809 The upregulation of hypoxia-related miRNA 210 in primary tumor of lymphogenic metastatic prostate cancer. -tissue_expression_up hsa-mir-1 "Carcinoma, Lung, Non-Small-Cell" 30114862 "MiR-1, miR-124, and miR-196a are overexpressed in EGFR T790M mutated NSCLC" -tissue_expression_up hsa-mir-124 "Carcinoma, Lung, Non-Small-Cell" 30114862 "MiR-1, miR-124, and miR-196a are overexpressed in EGFR T790M mutated NSCLC" -tissue_expression_up hsa-mir-196a "Carcinoma, Lung, Non-Small-Cell" 30114862 "MiR-1, miR-124, and miR-196a are overexpressed in EGFR T790M mutated NSCLC" -tissue_expression_up hsa-mir-195 Chronic Obstructive Pulmonary Disease 30115538 "FGFR1 was also a predicted target for some up-regulated miRNAs in COPD bronchial epithelial cells, including hsa-miR-195-5p, hsa-miR-424-5p, and hsa-miR-6724-5p" -tissue_expression_up hsa-mir-424 Chronic Obstructive Pulmonary Disease 30115538 "FGFR1 was also a predicted target for some up-regulated miRNAs in COPD bronchial epithelial cells, including hsa-miR-195-5p, hsa-miR-424-5p, and hsa-miR-6724-5p" -tissue_expression_up hsa-mir-6724 Chronic Obstructive Pulmonary Disease 30115538 "FGFR1 was also a predicted target for some up-regulated miRNAs in COPD bronchial epithelial cells, including hsa-miR-195-5p, hsa-miR-424-5p, and hsa-miR-6724-5p" -tissue_expression_up hsa-mir-125a Colon Neoplasms 30127618 "seven miRNAs (hsa-miR-920, hsa-miR-636, hsa-miR-766-3p, hsa-miR-545-5p, hsa-miR-195-3p, hsa-miR-125a-3p, and hsa-miR-196b-3p) were found to be upregulated and six miRNAs (hsa-miR-3613-3p, hsa-miR-29b-3p, hsa-miR-1297, hsa-miR-141-5p, hsa-miR-200c-3p, and hsa-miR-141-3p) were found to be downregulated" -tissue_expression_up hsa-mir-195 Colon Neoplasms 30127618 "seven miRNAs (hsa-miR-920, hsa-miR-636, hsa-miR-766-3p, hsa-miR-545-5p, hsa-miR-195-3p, hsa-miR-125a-3p, and hsa-miR-196b-3p) were found to be upregulated and six miRNAs (hsa-miR-3613-3p, hsa-miR-29b-3p, hsa-miR-1297, hsa-miR-141-5p, hsa-miR-200c-3p, and hsa-miR-141-3p) were found to be downregulated" -tissue_expression_up hsa-mir-196b Colon Neoplasms 30127618 "seven miRNAs (hsa-miR-920, hsa-miR-636, hsa-miR-766-3p, hsa-miR-545-5p, hsa-miR-195-3p, hsa-miR-125a-3p, and hsa-miR-196b-3p) were found to be upregulated and six miRNAs (hsa-miR-3613-3p, hsa-miR-29b-3p, hsa-miR-1297, hsa-miR-141-5p, hsa-miR-200c-3p, and hsa-miR-141-3p) were found to be downregulated" -tissue_expression_up hsa-mir-545 Colon Neoplasms 30127618 "seven miRNAs (hsa-miR-920, hsa-miR-636, hsa-miR-766-3p, hsa-miR-545-5p, hsa-miR-195-3p, hsa-miR-125a-3p, and hsa-miR-196b-3p) were found to be upregulated and six miRNAs (hsa-miR-3613-3p, hsa-miR-29b-3p, hsa-miR-1297, hsa-miR-141-5p, hsa-miR-200c-3p, and hsa-miR-141-3p) were found to be downregulated" -tissue_expression_up hsa-mir-636 Colon Neoplasms 30127618 "seven miRNAs (hsa-miR-920, hsa-miR-636, hsa-miR-766-3p, hsa-miR-545-5p, hsa-miR-195-3p, hsa-miR-125a-3p, and hsa-miR-196b-3p) were found to be upregulated and six miRNAs (hsa-miR-3613-3p, hsa-miR-29b-3p, hsa-miR-1297, hsa-miR-141-5p, hsa-miR-200c-3p, and hsa-miR-141-3p) were found to be downregulated" -tissue_expression_up hsa-mir-766 Colon Neoplasms 30127618 "seven miRNAs (hsa-miR-920, hsa-miR-636, hsa-miR-766-3p, hsa-miR-545-5p, hsa-miR-195-3p, hsa-miR-125a-3p, and hsa-miR-196b-3p) were found to be upregulated and six miRNAs (hsa-miR-3613-3p, hsa-miR-29b-3p, hsa-miR-1297, hsa-miR-141-5p, hsa-miR-200c-3p, and hsa-miR-141-3p) were found to be downregulated" -tissue_expression_up hsa-mir-920 Colon Neoplasms 30127618 "seven miRNAs (hsa-miR-920, hsa-miR-636, hsa-miR-766-3p, hsa-miR-545-5p, hsa-miR-195-3p, hsa-miR-125a-3p, and hsa-miR-196b-3p) were found to be upregulated and six miRNAs (hsa-miR-3613-3p, hsa-miR-29b-3p, hsa-miR-1297, hsa-miR-141-5p, hsa-miR-200c-3p, and hsa-miR-141-3p) were found to be downregulated" -tissue_expression_up hsa-mir-1225 Laryngeal Neoplasms 30138106 MicroRNA-1225-5p acts as a tumor-suppressor in laryngeal cancer via targeting CDC14B. -tissue_expression_up hsa-mir-421 "Carcinoma, Lung, Non-Small-Cell" 30147363 Upregulated expression of miR-421 is associated with poor prognosis in non-small-cell lung cancer. -tissue_expression_up hsa-mir-15b Uterine Leiomyoma 30149651 "The relative expression level of miR-15b was upregulated, and the relative expression levels of miR-29a, -29b, -29c, -197, and -200c were downregulated in UL cells compared to those in UM cells" -tissue_expression_up hsa-mir-223 Amyotrophic Lateral Sclerosis 30154826 Wide-Ranging Analysis of MicroRNA Profiles in Sporadic Amyotrophic Lateral Sclerosis Using Next-Generation Sequencing. -tissue_expression_up hsa-mir-336 Amyotrophic Lateral Sclerosis 30154826 Wide-Ranging Analysis of MicroRNA Profiles in Sporadic Amyotrophic Lateral Sclerosis Using Next-Generation Sequencing. -tissue_expression_up hsa-mir-510 Fragile X Syndrome 30160796 High expression of miR-510 was associated with CGG expansion located at upstream of FMR1 into full mutation. -tissue_expression_up hsa-mir-141 Cholangiocarcinoma 30165035 "the hsa-miR-205-5p and miR-200 family members were markedly up-regulated for 600-1500 folds, whereas the miR-199 family members and their clustered miRNA, hsa-miR-214-3p, were down-regulated for 1000-2000 folds" -tissue_expression_up hsa-mir-200a Cholangiocarcinoma 30165035 "the hsa-miR-205-5p and miR-200 family members were markedly up-regulated for 600-1500 folds, whereas the miR-199 family members and their clustered miRNA, hsa-miR-214-3p, were down-regulated for 1000-2000 folds" -tissue_expression_up hsa-mir-200b Cholangiocarcinoma 30165035 "the hsa-miR-205-5p and miR-200 family members were markedly up-regulated for 600-1500 folds, whereas the miR-199 family members and their clustered miRNA, hsa-miR-214-3p, were down-regulated for 1000-2000 folds" -tissue_expression_up hsa-mir-200c Cholangiocarcinoma 30165035 "the hsa-miR-205-5p and miR-200 family members were markedly up-regulated for 600-1500 folds, whereas the miR-199 family members and their clustered miRNA, hsa-miR-214-3p, were down-regulated for 1000-2000 folds" -tissue_expression_up hsa-mir-205 Cholangiocarcinoma 30165035 "the hsa-miR-205-5p and miR-200 family members were markedly up-regulated for 600-1500 folds, whereas the miR-199 family members and their clustered miRNA, hsa-miR-214-3p, were down-regulated for 1000-2000 folds" -tissue_expression_up hsa-mir-429 Cholangiocarcinoma 30165035 "the hsa-miR-205-5p and miR-200 family members were markedly up-regulated for 600-1500 folds, whereas the miR-199 family members and their clustered miRNA, hsa-miR-214-3p, were down-regulated for 1000-2000 folds" -tissue_expression_up hsa-let-7i Traumatic Brain Injury 30177873 "no significant variations of the 65 inflammatory proteins detected in saliva between groups but 5 microRNAs, miR-27b-3p (p = 0.016), let-7i-5p (p = 0.001), miR-142-3p(p = 0.008), miR-107 (p = 0.028), miR-135b-5p (p = 0.017) significantly upregulated in concussed athletes" -tissue_expression_up hsa-mir-107 Traumatic Brain Injury 30177873 "no significant variations of the 65 inflammatory proteins detected in saliva between groups but 5 microRNAs, miR-27b-3p (p = 0.016), let-7i-5p (p = 0.001), miR-142-3p(p = 0.008), miR-107 (p = 0.028), miR-135b-5p (p = 0.017) significantly upregulated in concussed athletes" -tissue_expression_up hsa-mir-135b Traumatic Brain Injury 30177873 "no significant variations of the 65 inflammatory proteins detected in saliva between groups but 5 microRNAs, miR-27b-3p (p = 0.016), let-7i-5p (p = 0.001), miR-142-3p(p = 0.008), miR-107 (p = 0.028), miR-135b-5p (p = 0.017) significantly upregulated in concussed athletes" -tissue_expression_up hsa-mir-142 Traumatic Brain Injury 30177873 "no significant variations of the 65 inflammatory proteins detected in saliva between groups but 5 microRNAs, miR-27b-3p (p = 0.016), let-7i-5p (p = 0.001), miR-142-3p(p = 0.008), miR-107 (p = 0.028), miR-135b-5p (p = 0.017) significantly upregulated in concussed athletes" -tissue_expression_up hsa-mir-27b Traumatic Brain Injury 30177873 "no significant variations of the 65 inflammatory proteins detected in saliva between groups but 5 microRNAs, miR-27b-3p (p = 0.016), let-7i-5p (p = 0.001), miR-142-3p(p = 0.008), miR-107 (p = 0.028), miR-135b-5p (p = 0.017) significantly upregulated in concussed athletes" -tissue_expression_up hsa-let-7f Irritable Bowel Syndrome 30187701 MiRNAs play a pivotal role in visceral hypersensitivity and might be targets in the treatment of IBS by Tongxieyaofang -tissue_expression_up hsa-let-7i Irritable Bowel Syndrome 30187701 MiRNAs play a pivotal role in visceral hypersensitivity and might be targets in the treatment of IBS by Tongxieyaofang -tissue_expression_up hsa-mir-130b Irritable Bowel Syndrome 30187701 MiRNAs play a pivotal role in visceral hypersensitivity and might be targets in the treatment of IBS by Tongxieyaofang -tissue_expression_up hsa-mir-132 Irritable Bowel Syndrome 30187701 MiRNAs play a pivotal role in visceral hypersensitivity and might be targets in the treatment of IBS by Tongxieyaofang -tissue_expression_up hsa-mir-21 Irritable Bowel Syndrome 30187701 MiRNAs play a pivotal role in visceral hypersensitivity and might be targets in the treatment of IBS by Tongxieyaofang -tissue_expression_up hsa-mir-29a Irritable Bowel Syndrome 30187701 MiRNAs play a pivotal role in visceral hypersensitivity and might be targets in the treatment of IBS by Tongxieyaofang -tissue_expression_up hsa-mir-375 Irritable Bowel Syndrome 30187701 MiRNAs play a pivotal role in visceral hypersensitivity and might be targets in the treatment of IBS by Tongxieyaofang -tissue_expression_up hsa-let-7b Endometrial Stromal Sarcoma 30200635 "In endometrial stromal sarcomas (ESS), the upregulation of miR-373-3p, miR-372-3p, and let-7b-5p, and the down-expression of let-7f-5p, miR-23-3p, and let-7b-5p were associated with lower CSS" -tissue_expression_up hsa-mir-184 Carcinosarcoma 30200635 "In carcinosarcoma (CS), lower CSS was associated with the upregulation of miR-184, and the downregulation of let-7b-5p and miR-124" -tissue_expression_up hsa-mir-196a Leiomyosarcoma 30200635 "In leiomyosarcoma (LMS), there was an association of lower cancer-specific survival (CSS) with the downregulation of miR-125a-5p and miR-10a-5p, and the upregulation of miR-196a-5p and miR-34c-5p" -tissue_expression_up hsa-mir-34c Leiomyosarcoma 30200635 "In leiomyosarcoma (LMS), there was an association of lower cancer-specific survival (CSS) with the downregulation of miR-125a-5p and miR-10a-5p, and the upregulation of miR-196a-5p and miR-34c-5p" -tissue_expression_up hsa-mir-372 Endometrial Stromal Sarcoma 30200635 "In endometrial stromal sarcomas (ESS), the upregulation of miR-373-3p, miR-372-3p, and let-7b-5p, and the down-expression of let-7f-5p, miR-23-3p, and let-7b-5p were associated with lower CSS" -tissue_expression_up hsa-mir-373 Endometrial Stromal Sarcoma 30200635 "In endometrial stromal sarcomas (ESS), the upregulation of miR-373-3p, miR-372-3p, and let-7b-5p, and the down-expression of let-7f-5p, miR-23-3p, and let-7b-5p were associated with lower CSS" -tissue_expression_up hsa-mir-450b "Squamous Cell Carcinoma, Oral" 30210912 "The expression levels of miR-129-5p and miR-296-5p were significantly downregulated in OLK-OSCC tissues compared to OLK tissues, while miR-450b-5p levels were higher in OLK-OSCC tissues" -tissue_expression_up hsa-mir-141 "Carcinoma, Cervical" 30221475 "The expression levels of six miRNAs (miR-20a, miR-92a, miR-141, miR-183*, miR-210 and miR-944) were found to be significantly up-regulated in cervical cancer" -tissue_expression_up hsa-mir-183 "Carcinoma, Cervical" 30221475 "The expression levels of six miRNAs (miR-20a, miR-92a, miR-141, miR-183*, miR-210 and miR-944) were found to be significantly up-regulated in cervical cancer" -tissue_expression_up hsa-mir-20a "Carcinoma, Cervical" 30221475 "The expression levels of six miRNAs (miR-20a, miR-92a, miR-141, miR-183*, miR-210 and miR-944) were found to be significantly up-regulated in cervical cancer" -tissue_expression_up hsa-mir-210 "Carcinoma, Cervical" 30221475 "The expression levels of six miRNAs (miR-20a, miR-92a, miR-141, miR-183*, miR-210 and miR-944) were found to be significantly up-regulated in cervical cancer" -tissue_expression_up hsa-mir-92a "Carcinoma, Cervical" 30221475 "The expression levels of six miRNAs (miR-20a, miR-92a, miR-141, miR-183*, miR-210 and miR-944) were found to be significantly up-regulated in cervical cancer" -tissue_expression_up hsa-mir-944 "Carcinoma, Cervical" 30221475 "The expression levels of six miRNAs (miR-20a, miR-92a, miR-141, miR-183*, miR-210 and miR-944) were found to be significantly up-regulated in cervical cancer" -tissue_expression_up hsa-mir-139 Neoplasms [unspecific] 30225717 "Bioinformatic analysis has detected microRNA potentially regulated by xenosensor receptors AhR (miR-28, miR-30c, miR-30e, miR-139, and miR-153) and CAR (miR-29c, miR-31, miR-185, miR-625, and miR-652)" -tissue_expression_up hsa-mir-153 Neoplasms [unspecific] 30225717 "Bioinformatic analysis has detected microRNA potentially regulated by xenosensor receptors AhR (miR-28, miR-30c, miR-30e, miR-139, and miR-153) and CAR (miR-29c, miR-31, miR-185, miR-625, and miR-652)" -tissue_expression_up hsa-mir-185 Neoplasms [unspecific] 30225717 "Bioinformatic analysis has detected microRNA potentially regulated by xenosensor receptors AhR (miR-28, miR-30c, miR-30e, miR-139, and miR-153) and CAR (miR-29c, miR-31, miR-185, miR-625, and miR-652)" -tissue_expression_up hsa-mir-28 Neoplasms [unspecific] 30225717 "Bioinformatic analysis has detected microRNA potentially regulated by xenosensor receptors AhR (miR-28, miR-30c, miR-30e, miR-139, and miR-153) and CAR (miR-29c, miR-31, miR-185, miR-625, and miR-652)" -tissue_expression_up hsa-mir-29c Neoplasms [unspecific] 30225717 "Bioinformatic analysis has detected microRNA potentially regulated by xenosensor receptors AhR (miR-28, miR-30c, miR-30e, miR-139, and miR-153) and CAR (miR-29c, miR-31, miR-185, miR-625, and miR-652)" -tissue_expression_up hsa-mir-30c Neoplasms [unspecific] 30225717 "Bioinformatic analysis has detected microRNA potentially regulated by xenosensor receptors AhR (miR-28, miR-30c, miR-30e, miR-139, and miR-153) and CAR (miR-29c, miR-31, miR-185, miR-625, and miR-652)" -tissue_expression_up hsa-mir-30e Neoplasms [unspecific] 30225717 "Bioinformatic analysis has detected microRNA potentially regulated by xenosensor receptors AhR (miR-28, miR-30c, miR-30e, miR-139, and miR-153) and CAR (miR-29c, miR-31, miR-185, miR-625, and miR-652)" -tissue_expression_up hsa-mir-31 Neoplasms [unspecific] 30225717 "Bioinformatic analysis has detected microRNA potentially regulated by xenosensor receptors AhR (miR-28, miR-30c, miR-30e, miR-139, and miR-153) and CAR (miR-29c, miR-31, miR-185, miR-625, and miR-652)" -tissue_expression_up hsa-mir-625 Neoplasms [unspecific] 30225717 "Bioinformatic analysis has detected microRNA potentially regulated by xenosensor receptors AhR (miR-28, miR-30c, miR-30e, miR-139, and miR-153) and CAR (miR-29c, miR-31, miR-185, miR-625, and miR-652)" -tissue_expression_up hsa-mir-183 Endometrial Neoplasms 30226564 "Upregulation of miR-183-5p is responsible for the promotion of apoptosis and inhibition of the epithelial-mesenchymal transition, proliferation, invasion and migration of human endometrial cancer cells by downregulating Ezrin." -tissue_expression_up hsa-mir-3195 Traumatic Brain Injury 30226895 The expression levels of miR-3195 and miR-328-5p were higher in the severe TBI group than in the mild and moderate TBI groups -tissue_expression_up hsa-mir-328 Traumatic Brain Injury 30226895 The expression levels of miR-3195 and miR-328-5p were higher in the severe TBI group than in the mild and moderate TBI groups -tissue_expression_up hsa-mir-486 Colorectal Carcinoma 30239392 MiR-486-5p Downregulation Marks an Early Event in Colorectal Carcinogenesis. -tissue_expression_up hsa-mir-211 Medulloblastoma 30244244 "Ligustrazine Inhibits Growth, Migration and Invasion of Medulloblastoma Daoy Cells by Up-Regulation of miR-211." -tissue_expression_up hsa-mir-155 "Carcinoma, Breast" 30250531 3 miRNAs were upregulated: Hsa-miR-21b; hsa-miR-29b; and hsa-miR-155; and 3 miRNAs were downregulated: Hsa-miR-10b; hsa-miR-125; and hsa-miR-145 -tissue_expression_up hsa-mir-21b "Carcinoma, Breast" 30250531 3 miRNAs were upregulated: Hsa-miR-21b; hsa-miR-29b; and hsa-miR-155; and 3 miRNAs were downregulated: Hsa-miR-10b; hsa-miR-125; and hsa-miR-145 -tissue_expression_up hsa-mir-29b "Carcinoma, Breast" 30250531 3 miRNAs were upregulated: Hsa-miR-21b; hsa-miR-29b; and hsa-miR-155; and 3 miRNAs were downregulated: Hsa-miR-10b; hsa-miR-125; and hsa-miR-145 -tissue_expression_up hsa-mir-484 "Carcinoma, Hepatocellular" 30254459 the expression of miR-10a-5p is downregulated and miR-484 is the most abundant miRNA in hepatic precancerous lesions -tissue_expression_up hsa-mir-107 Gastric Neoplasms 30258124 "Six miRNA (miR-601, miR-107, miR-18a, miR-370, miR-300, and miR-96) showed increased expression in gastric cancer compared to normal or adenoma samples" -tissue_expression_up hsa-mir-18a Gastric Neoplasms 30258124 "Six miRNA (miR-601, miR-107, miR-18a, miR-370, miR-300, and miR-96) showed increased expression in gastric cancer compared to normal or adenoma samples" -tissue_expression_up hsa-mir-300 Gastric Neoplasms 30258124 "Six miRNA (miR-601, miR-107, miR-18a, miR-370, miR-300, and miR-96) showed increased expression in gastric cancer compared to normal or adenoma samples" -tissue_expression_up hsa-mir-370 Gastric Neoplasms 30258124 "Six miRNA (miR-601, miR-107, miR-18a, miR-370, miR-300, and miR-96) showed increased expression in gastric cancer compared to normal or adenoma samples" -tissue_expression_up hsa-mir-601 Gastric Neoplasms 30258124 "Six miRNA (miR-601, miR-107, miR-18a, miR-370, miR-300, and miR-96) showed increased expression in gastric cancer compared to normal or adenoma samples" -tissue_expression_up hsa-mir-96 Gastric Neoplasms 30258124 "Six miRNA (miR-601, miR-107, miR-18a, miR-370, miR-300, and miR-96) showed increased expression in gastric cancer compared to normal or adenoma samples" -tissue_expression_up hsa-mir-29c Acute Liver Failure 30264499 Comparison of microRNA expressions for the identification of chemical hazards in in vivo and in vitro hepatic injury models. -tissue_expression_up hsa-mir-26b "Carcinoma, Hepatocellular" 30309482 Lentiviral-mediated microRNA-26b up-regulation inhibits proliferation and migration of hepatocellular carcinoma cells. -tissue_expression_up hsa-mir-21 Ischemia-Reperfusion Injury 30309483 MicroRNA-21 is upregulated during intestinal barrier dysfunction induced by ischemia reperfusion. -tissue_expression_up hsa-mir-193a "Carcinoma, Pancreatic" 30333874 "The results revealed that 2 upregulated miRNAs (miR-34a and -193a-3p) and 4 downregulated miRNAs (miR-221, -222, -484, and -502-3p) exhibited a consistent expression pattern between the PC-1.0/PC-1 and AsPC-1/CAPAN-2 pancreatic cancer cells" -tissue_expression_up hsa-mir-34a "Carcinoma, Pancreatic" 30333874 "The results revealed that 2 upregulated miRNAs (miR-34a and -193a-3p) and 4 downregulated miRNAs (miR-221, -222, -484, and -502-3p) exhibited a consistent expression pattern between the PC-1.0/PC-1 and AsPC-1/CAPAN-2 pancreatic cancer cells" -tissue_expression_up hsa-mir-155 "Carcinoma, Renal Cell" 30344735 "2 upregulated (hsa-miR-155-5p and hsa-miR-210-5p) and 6 downregulated (hsa-miR-138-5p, hsa-miR-141-5p, hsa-miR-200c-5p, hsa-miR-362-5p, hsa-miR-363-5p and hsa-miR-429) meta-signature miRNAs in renal carcinoma were identified" -tissue_expression_up hsa-mir-210 "Carcinoma, Renal Cell" 30344735 "2 upregulated (hsa-miR-155-5p and hsa-miR-210-5p) and 6 downregulated (hsa-miR-138-5p, hsa-miR-141-5p, hsa-miR-200c-5p, hsa-miR-362-5p, hsa-miR-363-5p and hsa-miR-429) meta-signature miRNAs in renal carcinoma were identified" -tissue_expression_up hsa-let-7b Periodontitis 30350903 "the most expressed miRNAs in both groups were hsa-miR-1274b, hsa-let-7b-5p, hsa-miR-24-3p, hsa-miR-19b-3p, hsa-miR-720, hsa-miR-126-3p, hsa-miR-17-3p and hsa-miR-21-3p." -tissue_expression_up hsa-mir-126 Periodontitis 30350903 "the most expressed miRNAs in both groups were hsa-miR-1274b, hsa-let-7b-5p, hsa-miR-24-3p, hsa-miR-19b-3p, hsa-miR-720, hsa-miR-126-3p, hsa-miR-17-3p and hsa-miR-21-3p." -tissue_expression_up hsa-mir-1274b Periodontitis 30350903 "the most expressed miRNAs in both groups were hsa-miR-1274b, hsa-let-7b-5p, hsa-miR-24-3p, hsa-miR-19b-3p, hsa-miR-720, hsa-miR-126-3p, hsa-miR-17-3p and hsa-miR-21-3p." -tissue_expression_up hsa-mir-17 Periodontitis 30350903 "the most expressed miRNAs in both groups were hsa-miR-1274b, hsa-let-7b-5p, hsa-miR-24-3p, hsa-miR-19b-3p, hsa-miR-720, hsa-miR-126-3p, hsa-miR-17-3p and hsa-miR-21-3p." -tissue_expression_up hsa-mir-19b Periodontitis 30350903 "the most expressed miRNAs in both groups were hsa-miR-1274b, hsa-let-7b-5p, hsa-miR-24-3p, hsa-miR-19b-3p, hsa-miR-720, hsa-miR-126-3p, hsa-miR-17-3p and hsa-miR-21-3p." -tissue_expression_up hsa-mir-21 Periodontitis 30350903 "the most expressed miRNAs in both groups were hsa-miR-1274b, hsa-let-7b-5p, hsa-miR-24-3p, hsa-miR-19b-3p, hsa-miR-720, hsa-miR-126-3p, hsa-miR-17-3p and hsa-miR-21-3p." -tissue_expression_up hsa-mir-24 Periodontitis 30350903 "the most expressed miRNAs in both groups were hsa-miR-1274b, hsa-let-7b-5p, hsa-miR-24-3p, hsa-miR-19b-3p, hsa-miR-720, hsa-miR-126-3p, hsa-miR-17-3p and hsa-miR-21-3p." -tissue_expression_up hsa-mir-720 Periodontitis 30350903 "the most expressed miRNAs in both groups were hsa-miR-1274b, hsa-let-7b-5p, hsa-miR-24-3p, hsa-miR-19b-3p, hsa-miR-720, hsa-miR-126-3p, hsa-miR-17-3p and hsa-miR-21-3p." -tissue_expression_up hsa-mir-1283 Parkinson Disease 30359694 "all three FTY720s increased miR376b-3p, while FTY720-C2 also increased miR-128-3p, miR-146b-5p, miR-7a-5p, and miR-9-5p, and FTY720-Mitoxy also increased miR-30d-5p" -tissue_expression_up hsa-mir-146b Parkinson Disease 30359694 "all three FTY720s increased miR376b-3p, while FTY720-C2 also increased miR-128-3p, miR-146b-5p, miR-7a-5p, and miR-9-5p, and FTY720-Mitoxy also increased miR-30d-5p" -tissue_expression_up hsa-mir-30d Parkinson Disease 30359694 "all three FTY720s increased miR376b-3p, while FTY720-C2 also increased miR-128-3p, miR-146b-5p, miR-7a-5p, and miR-9-5p, and FTY720-Mitoxy also increased miR-30d-5p" -tissue_expression_up hsa-mir-376b Parkinson Disease 30359694 "all three FTY720s increased miR376b-3p, while FTY720-C2 also increased miR-128-3p, miR-146b-5p, miR-7a-5p, and miR-9-5p, and FTY720-Mitoxy also increased miR-30d-5p" -tissue_expression_up hsa-mir-7a Parkinson Disease 30359694 "all three FTY720s increased miR376b-3p, while FTY720-C2 also increased miR-128-3p, miR-146b-5p, miR-7a-5p, and miR-9-5p, and FTY720-Mitoxy also increased miR-30d-5p" -tissue_expression_up hsa-mir-9 Parkinson Disease 30359694 "all three FTY720s increased miR376b-3p, while FTY720-C2 also increased miR-128-3p, miR-146b-5p, miR-7a-5p, and miR-9-5p, and FTY720-Mitoxy also increased miR-30d-5p" -tissue_expression_up hsa-mir-210 Rhinosinusitis 30378273 "Five upregulated miRNAs, including miR-210-5p, miR-3178, miR-585-3p, miR-3146, and miR-320e, and 19 downregulated miRNAs, including miR-32-3p, miR-1299, miR-3196, miR-3924, and miR-548e-3p, were differentially expressed (p < 0.05, fold change >2) in tissues of CRSwNP vs controls" -tissue_expression_up hsa-mir-3146 Rhinosinusitis 30378273 "Five upregulated miRNAs, including miR-210-5p, miR-3178, miR-585-3p, miR-3146, and miR-320e, and 19 downregulated miRNAs, including miR-32-3p, miR-1299, miR-3196, miR-3924, and miR-548e-3p, were differentially expressed (p < 0.05, fold change >2) in tissues of CRSwNP vs controls" -tissue_expression_up hsa-mir-3178 Rhinosinusitis 30378273 "Five upregulated miRNAs, including miR-210-5p, miR-3178, miR-585-3p, miR-3146, and miR-320e, and 19 downregulated miRNAs, including miR-32-3p, miR-1299, miR-3196, miR-3924, and miR-548e-3p, were differentially expressed (p < 0.05, fold change >2) in tissues of CRSwNP vs controls" -tissue_expression_up hsa-mir-320e Rhinosinusitis 30378273 "Five upregulated miRNAs, including miR-210-5p, miR-3178, miR-585-3p, miR-3146, and miR-320e, and 19 downregulated miRNAs, including miR-32-3p, miR-1299, miR-3196, miR-3924, and miR-548e-3p, were differentially expressed (p < 0.05, fold change >2) in tissues of CRSwNP vs controls" -tissue_expression_up hsa-mir-585 Rhinosinusitis 30378273 "Five upregulated miRNAs, including miR-210-5p, miR-3178, miR-585-3p, miR-3146, and miR-320e, and 19 downregulated miRNAs, including miR-32-3p, miR-1299, miR-3196, miR-3924, and miR-548e-3p, were differentially expressed (p < 0.05, fold change >2) in tissues of CRSwNP vs controls" -tissue_expression_up hsa-mir-1269a Neoplasms [unspecific] 30384176 Identification of key differentially expressed MicroRNAs in cancer patients through pan-cancer analysis.(up) -tissue_expression_up hsa-mir-183 Neoplasms [unspecific] 30384176 Identification of key differentially expressed MicroRNAs in cancer patients through pan-cancer analysis.(up) -tissue_expression_up hsa-mir-210 Neoplasms [unspecific] 30384176 Identification of key differentially expressed MicroRNAs in cancer patients through pan-cancer analysis.(up) -tissue_expression_up hsa-mir-301b Neoplasms [unspecific] 30384176 Identification of key differentially expressed MicroRNAs in cancer patients through pan-cancer analysis.(up) -tissue_expression_up hsa-mir-3648 Neoplasms [unspecific] 30384176 Identification of key differentially expressed MicroRNAs in cancer patients through pan-cancer analysis.(up) -tissue_expression_up hsa-mir-3687 Neoplasms [unspecific] 30384176 Identification of key differentially expressed MicroRNAs in cancer patients through pan-cancer analysis.(up) -tissue_expression_up hsa-mir-4746 Neoplasms [unspecific] 30384176 Identification of key differentially expressed MicroRNAs in cancer patients through pan-cancer analysis.(up) -tissue_expression_up hsa-mir-760 Neoplasms [unspecific] 30384176 Identification of key differentially expressed MicroRNAs in cancer patients through pan-cancer analysis.(up) -tissue_expression_up hsa-mir-96 Neoplasms [unspecific] 30384176 Identification of key differentially expressed MicroRNAs in cancer patients through pan-cancer analysis.(up) diff --git a/modulector/files/disease_hmdd.txt b/modulector/files/disease_hmdd.txt new file mode 100644 index 0000000..d9dc595 --- /dev/null +++ b/modulector/files/disease_hmdd.txt @@ -0,0 +1,53554 @@ +code PMID miRNA disease description +other 36948853 hsa-mir-40 Liver Cirrhosis MiR-340 mediates the involvement of high mobility group box 1 in the pathogenesis of liver fibrosis +target gene 36948479 hsa-mir-29b Zika Virus Infection Zika virus NS1 suppresses VE-cadherin via hsa-miR-29b-3p/DNMT3b/MMP-9 pathway in human brain microvascular endothelial cells. +exosome 36948039 hsa-mir-130b Wound Healing ADSCs-derived exosomal H19 accelerates cutaneous wound healing via the miR-130b-3p/PPARγ/STAT3 axis +target gene 36947996 hsa-mir-221 Stomach Neoplasms Downregulation of miR-221-3p promotes the ferroptosis in gastric cancer cells via upregulation of ATF3 to mediate the transcription inhibition of GPX4 and HRD1. +other 36947456 hsa-mir-497 Pancreatic Neoplasms Long noncoding RNA CASC9 promotes pancreatic cancer progression by acting as a ceRNA of miR-497-5p to upregulate expression of CCND1. +target gene 36947452 hsa-mir-511 Carcinoma, Non-Small-Cell Lung Hsa_circ_0003528 promotes cell malignant transformation and immune escape via increasing oncogene PDL1 through sponging miR-511-3p in non-small cell lung cancer. +genetics_knock down_suppress 36946780 hsa-mir-449b Liver Neoplasms LncRNA SLC9A3-AS1 knockdown increases the sensitivity of liver cancer cell to triptolide by regulating miR-449b-5p-mediated glycolysis. +target gene 36946346 hsa-mir-155 Neuroblastoma miR-155-5p alleviates lipopolysaccharide-induced inflammatory damage of human SH-SY5Y neuroblastoma cells by down-regulating SOCS1 +target gene 36946310 hsa-mir-6315 Spinal Cord Injuries miR-6315 silencing protects against spinal cord injury through the Smo and anti-ferroptosis pathway. +target gene 36946075 hsa-mir-145 Uterine Cervical Neoplasms miR-145 inhibits aerobic glycolysis and cell proliferation of cervical cancer by acting on MYC. +circulation_biomarker_diagnosis_ns 36945942 hsa-mir-21 Hypertension, Pulmonary Decreased circulating microRNA-21 and microRNA-143 are associated to pulmonary hypertension +circulation_biomarker_diagnosis_ns 36945942 hsa-mir-143 Hypertension, Pulmonary Decreased circulating microRNA-21 and microRNA-143 are associated to pulmonary hypertension +target gene 36944545 hsa-mir-515 Stomach Neoplasms Hsa_circ_0000670 promoted the progression of gastric cancer through the miR-515-5p/SIX1 molecular axis +target gene 36944544 hsa-mir-200b Retinoblastoma The effect of lncRNA ADPGK-AS1 on the proliferation and apoptosis of retinoblastoma cells by targeting miR-200b-5p +other 36944116 hsa-mir-425 Hepatitis B, Chronic miR-425-5p, miR-8485, miR-619-5p, miR-181a-5p, and miR-484 might increase the sensitivity to Peg-IFN α-2b therapy +other 36944116 hsa-mir-195 Hepatitis B, Chronic miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy +other 36944116 hsa-mir-429 Hepatitis B, Chronic miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy +other 36944116 hsa-mir-218 Hepatitis B, Chronic miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy +other 36944116 hsa-mir-181a Hepatitis B, Chronic miR-425-5p, miR-8485, miR-619-5p, miR-181a-5p, and miR-484 might increase the sensitivity to Peg-IFN α-2b therapy +other 36944116 hsa-mir-9 Hepatitis B, Chronic miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy +other 36944116 hsa-mir-8485 Hepatitis B, Chronic miR-425-5p, miR-8485, miR-619-5p, miR-181a-5p, and miR-484 might increase the sensitivity to Peg-IFN α-2b therapy +other 36944116 hsa-mir-215 Hepatitis B, Chronic miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy +other 36944116 hsa-mir-484 Hepatitis B, Chronic miR-425-5p, miR-8485, miR-619-5p, miR-181a-5p, and miR-484 might increase the sensitivity to Peg-IFN α-2b therapy +other 36944116 hsa-mir-619 Hepatitis B, Chronic miR-425-5p, miR-8485, miR-619-5p, miR-181a-5p, and miR-484 might increase the sensitivity to Peg-IFN α-2b therapy +other 36944116 hsa-mir-214 Hepatitis B, Chronic miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy +other 36944116 hsa-mir-16-2 Hepatitis B, Chronic miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy +other 36944116 hsa-mir-200b Hepatitis B, Chronic miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy +other 36944116 hsa-mir-141 Hepatitis B, Chronic miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy +other 36944116 hsa-mir-200c Hepatitis B, Chronic miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy +other 36944116 hsa-mir-130a Hepatitis B, Chronic miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy +other 36944116 hsa-mir-200a Hepatitis B, Chronic miR-195-5p, miR-215-5p, miR-9-5p, miR-130a-3p, miR-214-3p, miR-149-5p, miR-429, miR-200b-3p, miR-200c-3p, miR-16-2-3p, miR-141-3p, miR-200a-3p, and miR-218-5p might decrease the sensitivity to Peg-IFN α-2b therapy +target gene 36943627 hsa-mir-454 Breast Neoplasms LncRNA MIR17HG Suppresses Breast Cancer Proliferation and Migration as ceRNA to Target FAM135A by Sponging miR-454-3p. +target gene 36943602 hsa-mir-96 Liver Cirrhosis Anti-Liver Fibrosis Role of miRNA-96-5p via Targeting FN1 and Inhibiting ECM-Receptor Interaction Pathway. +target gene 36943433 hsa-mir-486 Psoriasis Downregulation of circ_0024028 inhibits IL-22-induced keratinocyte proliferation and migration by miR-486-3p/AKT3 axis +other 36941992 hsa-mir-27b Neuroblastoma CircRANBP17 modulated KDM1A to regulate neuroblastoma progression by sponging miR-27b-3p +exosome 36941991 hsa-mir-93 Osteoarthritis Exosomal miR-93-5p regulated the progression of osteoarthritis by targeting ADAMTS9. +target gene 36941464 hsa-mir-145 Breast Neoplasms LncRNA PVT1 influences breast cancer cells glycolysis through sponging miR-145-5p. +circulation_biomarker_diagnosis_ns 36941394 hsa-mir-19b Malaria Seven erythrocytic miRNAs, miR-451a, miR-92a-3p, miR-16-5p, miR-142-3p, miR-15b-5p, miR-19b-3p, and miR-223-3p showed favourable interactions with parasite genes expressed during blood stage infection. +circulation_biomarker_diagnosis_ns 36941394 hsa-mir-16 Malaria Seven erythrocytic miRNAs, miR-451a, miR-92a-3p, miR-16-5p, miR-142-3p, miR-15b-5p, miR-19b-3p, and miR-223-3p showed favourable interactions with parasite genes expressed during blood stage infection. +circulation_biomarker_diagnosis_ns 36941394 hsa-mir-92a Malaria Seven erythrocytic miRNAs, miR-451a, miR-92a-3p, miR-16-5p, miR-142-3p, miR-15b-5p, miR-19b-3p, and miR-223-3p showed favourable interactions with parasite genes expressed during blood stage infection. +circulation_biomarker_diagnosis_ns 36941394 hsa-mir-15b Malaria Seven erythrocytic miRNAs, miR-451a, miR-92a-3p, miR-16-5p, miR-142-3p, miR-15b-5p, miR-19b-3p, and miR-223-3p showed favourable interactions with parasite genes expressed during blood stage infection. +circulation_biomarker_diagnosis_ns 36941394 hsa-mir-451a Malaria Seven erythrocytic miRNAs, miR-451a, miR-92a-3p, miR-16-5p, miR-142-3p, miR-15b-5p, miR-19b-3p, and miR-223-3p showed favourable interactions with parasite genes expressed during blood stage infection. +circulation_biomarker_diagnosis_ns 36941394 hsa-mir-142 Malaria Seven erythrocytic miRNAs, miR-451a, miR-92a-3p, miR-16-5p, miR-142-3p, miR-15b-5p, miR-19b-3p, and miR-223-3p showed favourable interactions with parasite genes expressed during blood stage infection. +circulation_biomarker_diagnosis_ns 36941394 hsa-mir-223 Malaria Seven erythrocytic miRNAs, miR-451a, miR-92a-3p, miR-16-5p, miR-142-3p, miR-15b-5p, miR-19b-3p, and miR-223-3p showed favourable interactions with parasite genes expressed during blood stage infection. +other 36941055 hsa-mir-34a Alzheimer Disease miRNAs associated with abeta production (-101a, -15a, and -342) and proinflammation (-125b, -146a, and -34a) showed significant up-regulations in the tear fluids with disease progression, as tracked by cortical Abeta load and reactive astrogliosis. +other 36941055 hsa-mir-146a Alzheimer Disease miRNAs associated with abeta production (-101a, -15a, and -342) and proinflammation (-125b, -146a, and -34a) showed significant up-regulations in the tear fluids with disease progression, as tracked by cortical Abeta load and reactive astrogliosis. +other 36941055 hsa-mir-101a Alzheimer Disease miRNAs associated with abeta production (-101a, -15a, and -342) and proinflammation (-125b, -146a, and -34a) showed significant up-regulations in the tear fluids with disease progression, as tracked by cortical Abeta load and reactive astrogliosis. +other 36941055 hsa-mir-15a Alzheimer Disease miRNAs associated with abeta production (-101a, -15a, and -342) and proinflammation (-125b, -146a, and -34a) showed significant up-regulations in the tear fluids with disease progression, as tracked by cortical Abeta load and reactive astrogliosis. +other 36941055 hsa-mir-42 Alzheimer Disease miRNAs associated with abeta production (-101a, -15a, and -342) and proinflammation (-125b, -146a, and -34a) showed significant up-regulations in the tear fluids with disease progression, as tracked by cortical Abeta load and reactive astrogliosis. +other 36941055 hsa-mir-125b Alzheimer Disease miRNAs associated with abeta production (-101a, -15a, and -342) and proinflammation (-125b, -146a, and -34a) showed significant up-regulations in the tear fluids with disease progression, as tracked by cortical Abeta load and reactive astrogliosis. +target gene 36940068 hsa-mir-188 Atherosclerosis Circular RNA circ_0008896 contributes to oxidized low-density lipoprotein-induced aortic endothelial cell injury via targeting miR-188-3p/NOD2 axis +other 36939902 hsa-mir-210 Triple Negative Breast Neoplasms High HIF- 1a, miR-210 and beclin-1 as well as negative Bcl-2 were inversely related to pathologic complete response following NACT. +other 36939397 hsa-mir-146a Urinary Bladder Neoplasms Cancer-associated fibroblast-derived miR-146a-5p generates a niche that promotes bladder cancer stemness and chemoresistance +exosome 36939367 hsa-mir-29a Colorectal Neoplasms Exosome-transmitted miR-29a induces colorectal cancer metastasis by destroying the vascular endothelial barrier. +target gene 36939239 hsa-mir-140 Ovarian Neoplasms lncRNA AC005224.4/miR-140-3p/SNAI2 regulating axis facilitates the invasion and metastasis of ovarian cancer through epithelial-mesenchymal transition +exosome 36939028 hsa-mir-29b Stomach Neoplasms Intraperitoneal transfer of miR-29b-containing small extracellular vesicles can suppress peritoneal metastases of gastric cancer. +target gene 36938678 hsa-mir-20a Breast Neoplasms LINC00460 Facilitates Cell Proliferation and Inhibits Ferroptosis in Breast Cancer Through the miR-320a/MAL2 Axis. +target gene 36938448 hsa-mir-1281 Depression MiR-1281 is involved in depression disorder and the antidepressant effects of Kai-Xin-San by targeting ADCY1 and DVL1. +target gene 36937888 hsa-mir-490 renal fibrosis Emodin ameliorates renal injury and fibrosis via regulating the miR-490-3p/HMGA2 axis +target gene 36937804 hsa-mir-23a Pulmonary Disease, Chronic Obstructive miR-23a-5p and miR-194-3pare important biomarkers for COPD patients with OP (osteoporosis) and may represent novel targets for diagnosis and treatment of COPD patients with OP. +circulation_biomarker_diagnosis_up 36937162 hsa-mir-205 Alopecia Areata The serum expression of lncRNA HOTAIR was significantly downregulated in AA patients with a p value < 0.001, while the serum expression of both miRNA-205 and TGF-b1 were significantly upregulated in patients. +other 36936522 hsa-mir-29b Diabetic Cardiomyopathies Glucagon-Like Peptide-1 Receptor Agonist Protects Against Diabetic Cardiomyopathy by Modulating microRNA-29b-3p/SLMAP +other 36935520 hsa-mir-421 Osteoarthritis Circular RNA SLTM as a miR-421-competing endogenous RNA to mediate HMGB2 expression stimulates apoptosis and inflammation in arthritic chondrocytes. +other 36935173 hsa-mir-9 cervical squamous cell carcinoma Effects of miR-9-5p on the migration, invasion and epithelial-mesenchymal transition process in cervical squamous cell carcinoma. +target gene 36934373 hsa-mir-28 Lung Neoplasms Haplotype-GGGT in long non-coding RNA MALAT1 inhibits brain metastatic lung cancer and lymph nodes of lung cancer via the MALAT1/miR-328/KATNB1 +exosome 36934264 hsa-mir-107 Carcinoma, Non-Small-Cell Lung Exosomal MFI2-AS1 sponge miR-107 promotes non-small cell lung cancer progression through NFAT5. +target gene 36934152 hsa-mir-85 Liver Cirrhosis MIAT enhances the activation of HSCs, at least in part, via miR-3085-5p/YAP/EMT signaling pathway. +exosome 36934129 hsa-mir-663a Diabetic Nephropathies Urinary exosomal miRNA-663a shows variable expression in diabetic kidney disease patients with or without proteinuria. +other 36933242 hsa-mir-62 Myocardial Infarction MicroRNA-362-3p Implicated in Cardioprotection Against Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis by Repressing TP53INP2 and Regulating SDF-1/CXCR4 Pathway. +therapeutic target 36933170 hsa-mir-139 Thyroid Neoplasms miR-139-5p involvement in iodine uptake metabolism and suggests its possible role as a therapeutic target in restoring iodine uptake in RAI-refractory DTC. +target gene 36932454 hsa-mir-15b Glioblastoma circMMD reduction following tumor treating fields inhibits glioblastoma progression through FUBP1/FIR/DVL1 and miR-15b-5p/FZD6 signaling. +genetics_GWAS 36932446 hsa-mir-26a Glioma A three-microRNA signature (miR-1-3p/-26a-1-3p/-487b-3p) was differentially expressed in the serum of patients according to the isocitrate dehydrogenase (IDH) genes mutation status and correlated with both patient Overall and Progression Free Survival. +genetics_GWAS 36932446 hsa-mir-487b Glioma A three-microRNA signature (miR-1-3p/-26a-1-3p/-487b-3p) was differentially expressed in the serum of patients according to the isocitrate dehydrogenase (IDH) genes mutation status and correlated with both patient Overall and Progression Free Survival. +genetics_GWAS 36932446 hsa-mir-1 Glioma A three-microRNA signature (miR-1-3p/-26a-1-3p/-487b-3p) was differentially expressed in the serum of patients according to the isocitrate dehydrogenase (IDH) genes mutation status and correlated with both patient Overall and Progression Free Survival. +other 36932387 hsa-mir-127 Carcinoma, Hepatocellular The circCCAR1/miR-127-5p/WTAP feedback loop enhances the growth and metastasis of HCC. +target gene 36931409 hsa-mir-202 Atherosclerosis MicroRNA-202-5p-dependent inhibition of Bcl-2 contributes to macrophage apoptosis and atherosclerotic plaque formation. +circulation_biomarker_diagnosis_ns 36931262 hsa-mir-142 Polycystic Ovary Syndrome circulating microRNAs miR-142-3p and miR-598-3p in women with polycystic ovary syndrome as potential diagnostic markers +circulation_biomarker_diagnosis_ns 36931262 hsa-mir-598 Polycystic Ovary Syndrome circulating microRNAs miR-142-3p and miR-598-3p in women with polycystic ovary syndrome as potential diagnostic markers +genetics_GWAS 36931173 hsa-mir-1 Aortic Aneurysm, Abdominal The SNP rs4591246 in pri-miR-1-3p is associated with abdominal aortic aneurysm risk by regulating cell phenotypic transformation via the miR-1-3p/TLR4 axis. +exosome 36930410 hsa-mir-200b Carcinoma, Hepatocellular Exosomal miR-200b-3p induce macrophage polarization by regulating transcriptional repressor ZEB1 in hepatocellular carcinoma. +other 36930090 hsa-mir-17 Tuberculosis CeRNA network identified hsa-miR-17-5p, hsa-miR-106a-5p and hsa-miR-2355-5p as potential diagnostic biomarkers for tuberculosis. +other 36930090 hsa-mir-2355 Tuberculosis CeRNA network identified hsa-miR-17-5p, hsa-miR-106a-5p and hsa-miR-2355-5p as potential diagnostic biomarkers for tuberculosis. +other 36930090 hsa-mir-106a Tuberculosis CeRNA network identified hsa-miR-17-5p, hsa-miR-106a-5p and hsa-miR-2355-5p as potential diagnostic biomarkers for tuberculosis. +exosome 36929868 hsa-mir-455 Nasopharyngeal Carcinoma Hypoxic nasopharyngeal carcinoma-derived exosomal miR-455 increases vascular permeability by targeting ZO-1 to promote metastasis. +circulation_biomarker_diagnosis_ns 36929799 hsa-mir-146a Diabetes, Gestational A preliminary integrated analysis of miRNA-mRNA expression profiles reveals a role of miR-146a-3p/TRAF6 in plasma from gestational diabetes mellitus patients +target gene 36929708 hsa-mir-513b Prostatic Neoplasms Circular RNA LPAR3 targets JPT1 via microRNA-513b-5p to facilitate glycolytic activation but repress prostate cancer radiosensitivity. +other 36929702 hsa-mir-142 Nasopharyngeal Carcinoma MicroRNA-142-5p promotes the proliferation and metastasis of nasopharyngeal carcinoma. +target gene 36929422 hsa-mir-34a Colorectal Neoplasms NONHSAG028908.3 sponges miR-34a-5p to promote growth of colorectal cancer via targeting ALDOA. +other 36928742 hsa-mir-145 Squamous Cell Carcinoma of Head and Neck Circ_0058063 Contributed to Oral Squamous Cell Carcinoma Development by Sponging miR-145 and Regulating PI3K/AKT Pathway. +target gene 36927769 hsa-mir-409 Carcinoma, Hepatocellular BRF2 is mediated by microRNA-409-3p and promotes invasion and metastasis of HCC through the Wnt/β-catenin pathway. +exosome 36927608 hsa-mir-139 Myocardial Infarction Atorvastatin-pretreated mesenchymal stem cell-derived extracellular vesicles promote cardiac repair after myocardial infarction via shifting macrophage polarization by targeting microRNA-139-3p/Stat1 pathway. +genetics_GWAS 36926729 hsa-mir-34a Ischemic Stroke Genetic modification of miR-34a enhances efficacy of transplanted human dental pulp stem cells after ischemic stroke. +other 36926723 hsa-mir-181b Ischemic Stroke miR-181b promotes angiogenesis and neurological function recovery after ischemic stroke. +target gene 36925075 hsa-mir-27a Bronchiolitis Obliterans Syndrome miR-27a-3p alleviates lung transplantation-induced bronchiolitis obliterans syndrome (BOS) via suppressing Smad-mediated myofibroblast differentiation and TLR4-induced dendritic cells maturation. +target gene 36924565 hsa-mir-223 Rhinitis, Allergic MiR-223-3p regulates the eosinophil degranulation and enhances the inflammation in allergic rhinitis by targeting FBXW7. +target gene 36923408 hsa-mir-155 Sepsis CircRNA_0075723 protects against pneumonia-induced sepsis through inhibiting macrophage pyroptosis by sponging miR-155-5p and regulating SHIP1 expression. +other 36923098 hsa-mir-29b Squamous Cell Carcinoma of Head and Neck The lncRNA XIST/miR-29b-3p/COL3A1 axis regulates central carbon metabolism in head and neck squamous cell carcinoma and is associated with poor tumor prognosis. +circulation_biomarker_diagnosis_ns 36923095 hsa-mir-4488 Non-alcoholic Fatty Liver Disease Serum miR-4488 as a potential biomarker of lean nonalcoholic fatty liver disease. +other 36922872 hsa-mir-484 Carcinoma, Hepatocellular circFOXK2 upregulated the expression of protein FOXK2-142aa to promote LDHA phosphorylation and led to mitochondrial fission by regulating the miR-484/Fis1 pathway, ultimately activating the Warburg effect in HCC. +target gene 36922713 hsa-mir-1236 Ovarian Neoplasms VEGFR3 suppression through miR-1236 inhibits proliferation and induces apoptosis in ovarian cancer via ERK1/2 and AKT signaling pathways. +target gene 36920708 hsa-mir-873 Colorectal Neoplasms Circ_0005615 Regulates the Progression of Colorectal Cancer Through the miR-873-5p/FOSL2 Signaling Pathway. +target gene 36920626 hsa-mir-490 Neuroblastoma Hsa_circ_0001361 facilitates cell progression and glycolytic metabolism in neuroblastoma via interacting with mir-490-5p to induce TRIM2 upregulation. +target gene 36920269 hsa-mir-127 Breast Neoplasms Decreased miR-127 promotes the occurrence of breast cancer via increasing the expression of SPP1. +other 36920046 hsa-mir-637 Carcinoma, Hepatocellular Circ_0007429/miR-637/TRIM71/Ago2 axis participates in the regulation of proliferation, migration, invasion, apoptosis, and aerobic glycolysis of HCC. +target gene 36920044 hsa-mir-193a Colorectal Neoplasms Circular RNA ACACA negatively regulated p53-modulated mevalonate pathway to promote colorectal tumorigenesis via regulating miR-193a/b-3p/HDAC3 axis. +target gene 36919939 hsa-mir-29a Cerebral Hemorrhage Mechanism of SOX10 in ferroptosis of hippocampal neurons after intracerebral hemorrhage via the miR-29a-3p/ACSL4 axis. +target gene 36919011 hsa-mir-182 Cicatrix, Hypertrophic MicroRNA-182-5p Inhibits Hypertrophic Scar Formation by Inhibiting the Proliferation and Migration of Fibroblasts via SMAD4 Pathway. +other 36918702 hsa-mir-145 Colorectal Neoplasms miRNA-29a, miRNA-125b, miRNA-145 predicts the risk of colorectal cancer +other 36918702 hsa-mir-125b Colorectal Neoplasms miRNA-29a, miRNA-125b, miRNA-145 predicts the risk of colorectal cancer +other 36918702 hsa-mir-29a Colorectal Neoplasms miRNA-29a, miRNA-125b, miRNA-145 predicts the risk of colorectal cancer +target gene 36918335 hsa-mir-1224 Keloid Circ_0008450 regulates keloid-derived fibroblast proliferation, migration, invasion and apoptosis with increased IGFBP5 through sponging miR-1224-5p. +target gene 36917423 hsa-mir-204 Endometriosis Linc-ROR Promotes EMT by Targeting miR-204-5p/SMAD4 in Endometriosis. +target gene 36917402 hsa-mir-139 Hepatoblastoma miR-139-3p/Wnt5A Axis Inhibits Metastasis in Hepatoblastoma. +target gene 36917325 hsa-mir-24-1 Carcinoma, Renal Cell MiR-24-1-5p Hinders Malignant Phenotypes of Clear Cell Renal Cell Carcinoma by Targeting SHOX2. +target gene 36916542 hsa-mir-196a Thyroid Neoplasms MicroRNA-196a-5p targeting LRP1B modulates phenotype of thyroid carcinoma cells. +target gene 36916303 hsa-mir-592 Ovarian Neoplasms MicroRNA-592 Inhibits the Growth of Ovarian Cancer Cells by Targeting ERBB3. +target gene 36916297 hsa-mir-150 Colonic Neoplasms Ginsenoside Rh2 suppresses colon cancer growth by targeting the miR-150-3p/SRCIN1/Wnt axis. +other 36916095 hsa-mir-155 COVID-19 MicroRNA-155 is a main part of proinflammatory puzzle during severe coronavirus disease 2019 (COVID-19). +other 36916086 hsa-mir-17 Pneumonia Long noncoding RNA HOXA-AS2 ameliorates chronic intermittent hypoxia-induced lung inflammation by regulating miR-17-5p/tipe2 axis. +other 36916084 hsa-mir-23a Sepsis ATP2B1-AS1 exacerbates sepsis-induced cell apoptosis and inflammation by regulating miR-23a-3p/TLR4 axis. +exosome 36915886 hsa-mir-93 Urinary Bladder Neoplasms Exosomal miR-93-5p as an important driver of bladder cancer progression. +target gene 36915750 hsa-mir-101 Gastrointestinal Stromal Tumors Long noncoding RNA SPRY4-IT1 acts as a miR-101-5p sponge to promote gastrointestinal stromal tumor progression by inhibiting ZEB1. +other 36915463 hsa-mir-218 Colorectal Neoplasms Up-regulation of PUM1 by miR-218-5p promotes colorectal tumor-initiating cell properties and tumorigenesis by regulating the PI3K/AKT axis. +other 36915149 hsa-mir-296 Hypertension, Pulmonary Circ-Ntrk2 acts as a miR-296-5p sponge to activate the TGF-β1/p38 MAPK pathway and promote pulmonary hypertension and vascular remodelling. +target gene 36915137 hsa-mir-34a Osteoarthritis Metformin regulates chondrocyte senescence and proliferation through microRNA-34a/SIRT1 pathway in osteoarthritis. +other 36915125 hsa-mir-200c Prostatic Neoplasms CLIC6 and SCNN1A linked to miR-200c-3p had good prognostic potential and provided valuable insights into the pathogenesis of PCa. +target gene 36915121 hsa-mir-148b Irritable Bowel Syndrome apigenin dose-dependently abolished the inhibitory effect of IBS-exo on CACO-2 cell autophagy by regulating miR-148b-3p/ATG14 signaling. +target gene 36915057 hsa-mir-124 Endometriosis PCGEM1 promotes cell proliferation and migration in endometriosis by targeting miR-124-3p-mediated ANTXR2 expression. +target gene 36914604 hsa-mir-31 acute myocardial infarction LncRNA AC005332.7 Inhibited Ferroptosis to Alleviate Acute Myocardial Infarction Through Regulating miR-331-3p/CCND2 Axis. +exosome 36913799 hsa-mir-125b Acute Lung Injury miR-125b-5p in adipose derived stem cells exosome alleviates pulmonary microvascular endothelial cells ferroptosis via Keap1/Nrf2/GPX4 in sepsis lung injury. +target gene 36913151 hsa-mir-619 Pre-Eclampsia circPTK2 promotes proliferation, migration and invasion of trophoblast cells through the miR-619/WNT7B pathway in preeclampsia. +target gene 36913084 hsa-mir-429 Uterine Cervical Neoplasms Hsa_circ_0084912 Drives the Progression of Cervical Cancer Via Regulating miR-429/SOX2 Pathway. +target gene 36913076 hsa-mir-128 Prostatic Neoplasms Circ_0005276 Promotes Prostate Cancer Progression Through the Crosstalk of miR-128-3p/DEPDC1B Axis. +exosome 36912495 hsa-mir-196a Lung Neoplasms Exosomal miR-196a-5p enhances radioresistance in lung cancer cells by downregulating NFKBIA. +other 36912261 hsa-mir-74a Pancreatitis miR-374a-5p was downregulated in samples from AP patients +other 36912070 hsa-mir-61 Carcinoma, Non-Small-Cell Lung NCK1-AS1 promotes the proliferation, migration, invasion, and EMT of non-small cell lung cancer by regulating the miR-361-5p/ADAM10 axis. +other 36911684 hsa-mir-17 Adenocarcinoma of Lung LINC01798/miR-17-5p axis regulates ITGA8 and causes changes in tumor microenvironment and stemness in lung adenocarcinoma. +other 36911413 hsa-mir-203a Triple Negative Breast Neoplasms can predict the survival time of TNBC patients +other 36911413 hsa-mir-148b Triple Negative Breast Neoplasms can predict the survival time of TNBC patients +target gene 36911384 hsa-mir-129-2 Endometrial Neoplasms lncRNA XIST/miR-129-2-3p axis targets CCP110 to regulate the proliferation, invasion and migration of endometrial cancer cells. +target gene 36911069 hsa-mir-129 Carcinoma, Non-Small-Cell Lung 5-FU-miR-129 inhibited NSCLC tumor growth and extended survival in vivo without toxic side effects. +other 36910369 hsa-mir-16-1 Leukemia, Lymphocytic, Chronic, B-Cell Decreased expression of hsa-miR-16-1 is remarkable. +other 36910147 hsa-mir-16 Pre-Eclampsia Expression of hsa-miR-16-5p and hsa-miR-210 reflects maternal pathophysiological status, while hsa-miR-29b-3p reflects placental status. +other 36910147 hsa-mir-29b Pre-Eclampsia Expression of hsa-miR-16-5p and hsa-miR-210 reflects maternal pathophysiological status, while hsa-miR-29b-3p reflects placental status. +other 36910147 hsa-mir-210 Pre-Eclampsia Expression of hsa-miR-16-5p and hsa-miR-210 reflects maternal pathophysiological status, while hsa-miR-29b-3p reflects placental status. +circulation_biomarker_diagnosis_ns 36909377 hsa-mir-885 Carcinoma, Ovarian Epithelial three miRNAs from EOC serum (hsa-miR-1909-5p, hsa-miR-885-5p and hsa-let-7d-3p) and one microRNA from tissue samples (hsa-miR-200c-3p) were validated as significant to distinguish patients with EOC from HIs. +circulation_biomarker_diagnosis_ns 36909377 hsa-mir-200c Carcinoma, Ovarian Epithelial three miRNAs from EOC serum (hsa-miR-1909-5p, hsa-miR-885-5p and hsa-let-7d-3p) and one microRNA from tissue samples (hsa-miR-200c-3p) were validated as significant to distinguish patients with EOC from HIs. +circulation_biomarker_diagnosis_ns 36909377 hsa-mir-1909 Carcinoma, Ovarian Epithelial three miRNAs from EOC serum (hsa-miR-1909-5p, hsa-miR-885-5p and hsa-let-7d-3p) and one microRNA from tissue samples (hsa-miR-200c-3p) were validated as significant to distinguish patients with EOC from HIs. +circulation_biomarker_diagnosis_ns 36909377 hsa-let-7d Carcinoma, Ovarian Epithelial three miRNAs from EOC serum (hsa-miR-1909-5p, hsa-miR-885-5p and hsa-let-7d-3p) and one microRNA from tissue samples (hsa-miR-200c-3p) were validated as significant to distinguish patients with EOC from HIs. +other 36909201 hsa-mir-100 Respiratory Distress Syndrome miR-100 could serve as novel potential therapeutic molecule in the amelioration of ARDS +target gene 36908850 hsa-mir-19 Uterine Cervical Neoplasms miR-19-3p Targets PTEN to Regulate Cervical Cancer Cell Proliferation, Invasion, and Autophagy. +target gene 36908326 hsa-mir-627 Colorectal Neoplasms microRNA-627-5p inhibits colorectal cancer cell proliferation, migration and invasion by targeting Wnt2. +target gene 36908025 hsa-mir-196b Ovarian Neoplasms Circ_0078607 increases platinum drug sensitivity via miR-196b-5p/GAS7 axis in ovarian cancer. +target gene 36907052 hsa-mir-34a Triple Negative Breast Neoplasms MALAT-1 mediates innate and adaptive immune suppression events partially via targeting miR-34a/MICA/B and miR-175p/PD-L1/B7-H4 axes in TNBC patients and cell lines +other 36906874 hsa-mir-137 Prostatic Neoplasms lncRNA-PCMF1/hsa-miR-137/Twist1 Axis Involved in the EMT Regulation of Prostate Cancer Cells +other 36906716 hsa-mir-195 uterine corpus endometrial carcinoma miR-195-5P negatively regulated the expression of PSAT1 in UCEC. +target gene 36905560 hsa-mir-79 Glioblastoma Circular RNA circ_0000741/miR-379-5p/TRIM14 signaling axis promotes HDAC inhibitor (SAHA) tolerance in glioblastoma. +target gene 36905464 hsa-mir-20b Breast Neoplasms Silibinin had a strong anti-tumorigenic activity through BCL2L11upregulation and MiR-20b down expression +target gene 36905318 hsa-mir-182 Breast Neoplasms Stat5 inhibits NLRP3-mediated pyroptosis to enhance chemoresistance of breast cancer cells via promoting miR-182 transcription. +other 36905274 hsa-mir-34a colorectal adenocarcinoma The relative expression of miR-34a and miR-34b in colorectal adenocarcinoma tissues was less than that in the corresponding distal cutaneous normal mucosa +other 36905274 hsa-mir-4b colorectal adenocarcinoma The relative expression of miR-34a and miR-34b in colorectal adenocarcinoma tissues was less than that in the corresponding distal cutaneous normal mucosa +other 36902848 hsa-mir-196b Glioblastoma Possible Effect on Temozolomide Sensitivity +other 36902848 hsa-mir-195 Glioblastoma Possible Effect on Temozolomide Sensitivity +other 36902848 hsa-mir-648 Glioblastoma Possible Effect on Temozolomide Sensitivity +other 36902848 hsa-mir-767 Glioblastoma Possible Effect on Temozolomide Sensitivity +other 36902848 hsa-mir-181c Glioblastoma Possible Effect on Temozolomide Sensitivity +other 36902848 hsa-mir-181d Glioblastoma Possible Effect on Temozolomide Sensitivity +target gene 36902482 hsa-mir-29b Triple Negative Breast Neoplasms By inhibiting the expression level of miR-29b-3p, it was shown that complex regulatory pathways targeted this transcript in TNBC cells. +other 36902184 hsa-mir-199a Squamous Cell Carcinoma of Head and Neck MiR-199a-5p-Regulated SMARCA4 Promotes Oral Squamous Cell Carcinoma Tumorigenesis. +exosome 36902024 hsa-mir-21 Carcinoma, Hepatocellular Hepatocellular Carcinoma Cell-Derived Exosomal miR-21-5p Induces Macrophage M2 Polarization by Targeting RhoB. +other 36901866 hsa-mir-93 Endometriosis The expression of miR-30a (p = 0.0018) and miR-93 (p = 0.0052) was significantly upregulated in the eutopic endometrium of women with endometriosis compared to the controls. +other 36901866 hsa-mir-143 Endometriosis MiR-143 (p = 0.0225) expression also showed a statistical difference between the eutopic endometrium of women with endometriosis and the control group. +other 36901860 hsa-mir-149 Precursor Cell Lymphoblastic Leukemia-Lymphoma SNVs rs2292832 (MIR149), rs2043556 (MIR605), and rs10505168 (MIR2053) were associated with an increased risk of developing Neurological Toxicity +other 36901860 hsa-mir-23b Precursor Cell Lymphoblastic Leukemia-Lymphoma MIR323B (rs56103835) were associated with protection from gastrointestinal toxicity +other 36901860 hsa-mir-200c Precursor Cell Lymphoblastic Leukemia-Lymphoma SNVs rs12904 (MIR200C), rs3746444 (MIR499A) were associated with a lower risk for severe hematologic toxicity during ALL treatment. +other 36901860 hsa-mir-499a Precursor Cell Lymphoblastic Leukemia-Lymphoma SNVs rs12904 (MIR200C), rs3746444 (MIR499A) were associated with a lower risk for severe hematologic toxicity during ALL treatment. +other 36901860 hsa-mir-2053 Precursor Cell Lymphoblastic Leukemia-Lymphoma SNVs rs2292832 (MIR149), rs2043556 (MIR605), and rs10505168 (MIR2053) were associated with an increased risk of developing Neurological Toxicity +other 36901860 hsa-mir-938 Precursor Cell Lymphoblastic Leukemia-Lymphoma rs2505901 (MIR938) was associated with protection from this toxicity +other 36901860 hsa-mir-605 Precursor Cell Lymphoblastic Leukemia-Lymphoma SNVs rs2292832 (MIR149), rs2043556 (MIR605), and rs10505168 (MIR2053) were associated with an increased risk of developing Neurological Toxicity +other 36901760 hsa-mir-483 Pterygium RT-qPCR gene expression analysis confirmed IGF2 upregulation and demonstrated miR-483 expression in pterygium compared to normal conjunctiva (253.2-fold and 12.47-fold, respectively) +other 36901745 hsa-mir-203a Osteoarthritis miR203a-3p displayed a protective role reducing the inflammatory effects +genetics_overexpression_suppress 36901700 hsa-mir-101 Carcinoma, Hepatocellular HCC patients with TGFBR1 overexpression and downregulated hsa-miR-101-3p and hsa-miR-490-3p demonstrated a significantly poorer prognosis in TCGA_LIHC. +genetics_overexpression_suppress 36901700 hsa-mir-490 Carcinoma, Hepatocellular HCC patients with TGFBR1 overexpression and downregulated hsa-miR-101-3p and hsa-miR-490-3p demonstrated a significantly poorer prognosis in TCGA_LIHC. +circulation_biomarker_diagnosis_ns 36899831 hsa-mir-146a Alzheimer Disease Alzheimer's Disease Identified MicroRNA-146a-5p as Blood Marker with Anti-Inflammatory Function in Astrocyte Cells. +target gene 36899278 hsa-mir-122 Dyslipidemias miR-122 dysregulation is associated with type 2 diabetes mellitus-induced dyslipidemia and hyperglycemia independently of its rs17669 variant. +target gene 36899270 hsa-mir-510 Nasopharyngeal Carcinoma Long Non-Coding RNA Small Nucleolar RNA Host Gene 4 Induced by Transcription Factor SP1 Promoted the Progression of Nasopharyngeal Carcinoma Through Modulating microRNA-510-5p/Centromere Protein F Axis. +target gene 36899199 hsa-mir-139 Esophageal Neoplasms MiR-139 Affects Radioresistance in Esophageal Cancer by Targeting the PDK1/AKT/Cyclin D1 Signaling Pathway. +exosome 36898846 hsa-mir-885 Stomach Neoplasms Fusobacterium nucleatum induced exosomal HOTTIP promotes gastric cancer progression through miR-885-3p/EphB2 axis. +target gene 36897170 hsa-mir-424 Osteosarcoma A novel circular RNA circRBMS3 regulates proliferation and metastasis of osteosarcoma by targeting miR-424-eIF4B/YRDC axis. +circulation_biomarker_diagnosis_up 36896567 hsa-mir-200c Carcinoma, Ovarian Epithelial circDENND4C, a novel serum marker for epithelial ovarian cancer, acts as a tumor suppressor by downregulating miR-200b/c. +circulation_biomarker_diagnosis_up 36896567 hsa-mir-200b Carcinoma, Ovarian Epithelial circDENND4C, a novel serum marker for epithelial ovarian cancer, acts as a tumor suppressor by downregulating miR-200b/c. +exosome 36895784 hsa-mir-24 Inflammatory Bowel Diseases TNF-a Enhances the Therapeutic Effects of MenSC-Derived Small Extracellular Vesicles on Inflammatory Bowel Disease through Macrophage Polarization by miR-24-3p. +target gene 36895489 hsa-mir-181a Colorectal Neoplasms The BAP31/miR-181a-5p/RECK axis promotes angiogenesis in colorectal cancer via fibroblast activation. +target gene 36894989 hsa-mir-760 Osteoarthritis MiR-760 targets HBEGF to control cartilage extracellular matrix degradation in osteoarthritis. +target gene 36893940 hsa-mir-17 Adenocarcinoma of Lung CircSMARCA5 silencing impairs cell proliferation and invasion via the miR-17-3p-EGFR signaling in lung adenocarcinoma. +other 36893709 hsa-mir-133a Triple Negative Breast Neoplasms MiR-133a/CD47 axis is a novel prognostic biomarker to promote triple negative breast cancer progression. +other 36892621 hsa-mir-125a Medulloblastoma Lower levels of microRNA-125a showed a tendency toward poor survival rates; +target gene 36892495 hsa-mir-152 Ovarian Neoplasms Evodiamine inhibits malignant progression of ovarian cancer cells by regulating lncRNA-NEAT1/miR-152-3p/CDK19 axis. +target gene 36892025 hsa-mir-515 Stomach Neoplasms circ_0006089 facilitates gastric cancer progression via decoying miR-515-5p and up-regulating CXCL6. +therapeutic target 36891498 hsa-mir-29b Muscular Atrophy small-molecule inhibitor of miR-29b that could act as a potential therapeutic agent for muscle atrophy +other 36890588 hsa-mir-494 Intervertebral Disc Degeneration miR-494/SIRT3/mitophagy signaling pathway is responsible for the apoptosis and mitochondrial dysfunction of NP cells and that DHJSD may exert protective effects against IVD degeneration by regulating the miR-494/SIRT3/mitophagy signal axis. +target gene 36890438 hsa-mir-218 Atherosclerosis MicroRNA-218-5p regulates inflammation response via targeting TLR4 in atherosclerosis. +genetics_knock down_promote 36890211 hsa-mir-200b Colorectal Neoplasms Loss of exosomal miR-200b-3p from hypoxia cancer-associated fibroblasts promotes tumorigenesis and reduces sensitivity to 5-Flourouracil in colorectal cancer via upregulation of ZEB1 and E2F3. +other 36889776 hsa-mir-195 Uterine Cervical Neoplasms LncRNA CERS6-AS1 Is a Tumor Promoter in Cervical Cancer by Sponging miR-195-5p. +other 36889771 hsa-mir-525 Carcinoma, Non-Small-Cell Lung LncRNA SNHG12 Decreases Non-Small Cell Lung Cancer Cell Sensitivity to Cisplatin by Repressing miR-525-5p and Promoting XIAP. +target gene 36889769 hsa-mir-26a Breast Neoplasms MiR-26a-5p Heightens Breast Cancer Cell Sensitivity to Paclitaxel via Targeting Flap Endonuclease 1. +target gene 36889766 hsa-mir-490 Adenocarcinoma of Lung MiR-490-3p Sponged by lncRNA NEAT1 Can Attenuate Lung Adenocarcinoma Progression by Suppressing the RhoA/ROCK Signaling Pathway. +target gene 36889764 hsa-mir-118 Colorectal Neoplasms Long Non-Coding RNA HAND2 Antisense RNA 1 Inhibits Colorectal Cancer Development by Sponging microRNA-3118/Leptin Receptor Axis. +genetics_knock down_suppress 36889763 hsa-mir-70 Uterine Cervical Neoplasms CircCCNB1 Knockdown Blocks the Progression of Cervical Cancer by Acting as Competing Endogenous RNA in the miR-370-3p/SOX4 Pathway. +target gene 36889762 hsa-mir-218 Carcinoma, Non-Small-Cell Lung Targeting TRIM9 by miR-218-5p Restricts Cell Proliferation and Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer. +target gene 36889558 hsa-mir-154 Adenocarcinoma of Lung LINC00115 regulates lung adenocarcinoma progression via sponging miR-154-3p to modulate Sp3 expression. +target gene 36889174 hsa-mir-152 Colorectal Neoplasms miR-152-3p facilitates cell adhesion and hepatic metastases in colorectal cancer via targeting AQP11. +therapeutic target 36888755 hsa-mir-766 Sepsis circPTK2/miR-766/eIF5A axis ameliorates septic ALI, developing a novel therapeutic target for the disease +target gene 36884182 hsa-mir-124 Prostatic Neoplasms MiR-124-3p inhibits tumor progression in prostate cancer by targeting EZH2. +target gene 36884165 hsa-mir-136 Esophageal Squamous Cell Carcinoma Circ-FNDC3B Functions as an Oncogenic Factor in Esophageal Squamous Cell Carcinoma via Upregulating MYO5A by Absorbing miR-136-5p and miR-370-3p. +other 36883849 hsa-mir-155 Neuroinflammatory Diseases MicroRNA-155 Plays Selective Cell-Intrinsic Roles in Brain-Infiltrating Immune Cell Populations during Neuroinflammation. +target gene 36882858 hsa-mir-34a Ototoxicity miR-34a/DRP-1-mediated mitophagy participated in cisplatin-induced ototoxicity via increasing oxidative stress. +other 36882799 hsa-mir-146b Carcinoma, Renal Cell MiR-146b-5p/SEMA3G regulates epithelial-mesenchymal transition in clear cell renal cell carcinoma. +other 36882663 hsa-mir-16 pancreatic adenocarcinoma The lncRNA PVT1/hsa-miR-16-5p/CASP6/CASP8 regulatory axis plays an vital role in regulating the anti-tumor immune responses for PAAD. +other 36882006 hsa-mir-34a COVID-19 miR-28, miR-34a, and miR181a could be helpful as potent biomarkers for diagnosing and controlling COVID-19. +other 36882006 hsa-mir-181a COVID-19 miR-28, miR-34a, and miR181a could be helpful as potent biomarkers for diagnosing and controlling COVID-19. +other 36882006 hsa-mir-28 COVID-19 miR-28, miR-34a, and miR181a could be helpful as potent biomarkers for diagnosing and controlling COVID-19. +other 36881359 hsa-mir-136 Carcinoma, Hepatocellular Hsa-circ-0000098 promotes the progression of hepatocellular carcinoma by regulation of miR-136-5p/MMP2 axis. +target gene 36881345 hsa-mir-29b Osteoporosis microRNA-29b-3p/sirtuin-1/peroxisome proliferator-activated receptor γ suppress osteogenic differentiation. +target gene 36881338 hsa-mir-1 Colorectal Neoplasms CircAGO2 promotes colorectal cancer progression by inhibiting heat shock protein family B (small) member 8 via miR-1-3p/retinoblastoma binding protein 4 axis. +target gene 36880587 hsa-mir-24 Osteosarcoma MicroRNA-324-3p inhibits osteosarcoma progression by suppressing PGAM1-mediated aerobic glycolysis. +target gene 36880288 hsa-mir-128 Alzheimer Disease MicroRNA-128 suppresses tau phosphorylation and reduces amyloid-beta accumulation by inhibiting the expression of GSK3β, APPBP2, and mTOR in Alzheimer's disease. +target gene 36880039 hsa-mir-147b Stomach Neoplasms MIR-147B Regulated Proliferation and Apoptosis of Gastric Cancer Cells by Targeting CPEB2 Via the PTEN Pathway. +circulation_biomarker_diagnosis_ns 36879801 hsa-mir-17 Fabry Disease Exercise-intolerance, blood-lactate increase, and the underlying miR-17/HIF-1 pathway may become useful therapeutic targets and diagnostic/monitoring tools in FD. +other 36879212 hsa-mir-6756 pancreatic ductal adenocarcinoma LINC01547/hsa-miR-4694-3p/LPAR1 and LINC00482/hsa-miR-6756-3p/RCAN2 play important roles in the carcinogenesis process of chronic pancreatitis. +other 36879212 hsa-mir-4694 pancreatic ductal adenocarcinoma LINC01547/hsa-miR-4694-3p/LPAR1 and LINC00482/hsa-miR-6756-3p/RCAN2 play important roles in the carcinogenesis process of chronic pancreatitis. +target gene 36879069 hsa-mir-30 Atherosclerosis miR-330-3p alleviates the progression of atherosclerosis by downregulating AQP9. +target gene 36878000 hsa-mir-74b Multiple Sclerosis MAGI2-AS3 and miR-374b-5p as Putative Regulators of Multiple Sclerosis via Modulating the PTEN/AKT/IRF-3/IFN-β Axis +other 36877445 hsa-mir-203a obsolete Helicobacter pylori infectious disease H. pylori could contribute to the process of carcinogenesis by downregulating miR-203a +target gene 36876834 hsa-mir-29c esophageal carcinoma E2F1 Reduces Sorafenib's Sensitivity of Esophageal Carcinoma Cells via Modulating the miR-29c-3p/COL11A1 Signaling Axis. +target gene 36876724 hsa-mir-144 Carcinoma, Non-Small-Cell Lung Circular RNA circDLG1 (has_circ_0068706) functions as an oncogene in non-small cell lung cancer through regulating AKT/mTOR signaling and direct binding to miR-144. +target gene 36876422 hsa-mir-211 Stomach Neoplasms LncRNA ELFN1-AS1 upregulates TRIM29 by suppressing miR-211-3p to promote gastric cancer progression. +target gene 36874625 hsa-mir-26b Colorectal Neoplasms lncRNA HCG11 Promotes Colorectal Cancer Cell Malignant Behaviors via Sponging miR-26b-5p. +circulation_biomarker_diagnosis_ns 36874371 hsa-mir-92a Ischemic Stroke Serum miR-92a and miR-375 could be promising early detective biomarkers of AIS. +circulation_biomarker_diagnosis_ns 36874371 hsa-mir-75 Ischemic Stroke Serum miR-92a and miR-375 could be promising early detective biomarkers of AIS. +target gene 36874361 hsa-mir-610 Melanoma LINC00511 promotes melanoma progression by targeting miR-610/NUCB2. +other 36873400 hsa-mir-21 Atrial Fibrillation miR-21-5p as a biomarker that reflects the extent of left atrial fibrosis in AF patients. +target gene 36873253 hsa-mir-221 Carcinoma, Non-Small-Cell Lung TP63 Functions as a Tumor Suppressor Regulated by GAS5/miR-221-3p Signaling Axis in Human Non-Small Cell Lung Cancer Cells. +target gene 36873181 hsa-mir-23b Pulmonary Fibrosis A novel and low-toxic peptide DR3penA alleviates pulmonary fibrosis by regulating the MAPK/miR-23b-5p/AQP5 signaling axis. +genetics_knock down_promote 36872771 hsa-mir-29a Ischemic Stroke CircSEC11A knockdown alleviates oxidative stress and apoptosis and promotes cell proliferation and angiogenesis by regulating miR-29a-3p/SEMA3A axis in OGD-induced human brain microvascular endothelial cells (HBMECs). +other 36872450 hsa-mir-26b Eosinophilic Esophagitis miR-26b-5p deregulated in saliva +other 36872450 hsa-mir-142 Eosinophilic Esophagitis miR-142-5p deregulated in saliva +other 36872450 hsa-let-7i Eosinophilic Esophagitis Let-7i-5p deregulated in saliva +other 36872450 hsa-mir-205 Eosinophilic Esophagitis miR-205-5p deregulated in saliva +other 36872450 hsa-mir-27b Eosinophilic Esophagitis miR-27b-3p deregulated in saliva +other 36871032 hsa-mir-424 Infertility, Male upregulated miRNA, notably miR-424 +target gene 36870548 hsa-mir-5009 Adenocarcinoma of Lung LncRNA ADAMTS9-AS1 inhibits the stemness of lung adenocarcinoma cells by regulating miR-5009-3p/NPNT axis. +other 36869885 hsa-mir-71a Testicular Neoplasms microRNA-371a-3p showed significantly higher expression rates than other markers suggesting its superior clinical usefulness. +circulation_biomarker_diagnosis_ns 36869070 hsa-mir-21 Brain Injuries, Traumatic Circulating MiRNA-21-enriched extracellular vesicles promote bone remodeling in traumatic brain injury patients. +other 36869031 hsa-mir-136 Endometrial Neoplasms PVT1/miR-136/Sox2/UPF1 axis regulates the malignant phenotypes of endometrial cancer stem cells. +circulation_biomarker_diagnosis_up 36868502 hsa-mir-1271 Endometriosis blood MiR-1271-5p and hsa-miR-490-3pin microRNA expression were significantly raised in the endometriosis group as opposed to the control group +circulation_biomarker_diagnosis_up 36868502 hsa-mir-490 Endometriosis blood MiR-1271-5p and hsa-miR-490-3pin microRNA expression were significantly raised in the endometriosis group as opposed to the control group +lncRNA target 36867300 hsa-mir-218 Glioma CircRNA-104718 modulates glioma cell proliferation through the miR +other 36867268 hsa-mir-4428 Adenocarcinoma of Lung In conclusion, circGRAMD1B is discovered to modulate miR-4428/SOX4/MEX3A axis to further activate PI3K/AKT pathway, finally boosting migration, invasion, and EMT of LUAD cells. +exosome 36866739 hsa-mir-143 Osteosarcoma Briefly, transfer of exosomal miR1433p confers doxorubicin resistance in osteosarcoma cells. +circulation_biomarker_diagnosis_ns 36865390 hsa-mir-1246 Breast Neoplasms The expression levels of circulation miR-1246, HOTAIR, and IL-39 could be considered early diagnostic biomarkers in BC patients. +other 36864416 hsa-mir-183 Stomach Neoplasms "RESULTS: A robust microRNA regulated network module was identified to characterize GC progression, which consisted of seven miR-200/183 family members, five mRNAs and two long non-coding RNAs H19 and CLLU1. CONCLUSIONS: Our strategy which combines AI-assisted bioinformatics method with experimental and clinical validation suggested that the miR-200/183 family-mediated network module as a ""pluripotent module"", which could be potential marker for GC progression." +other 36864416 hsa-mir-200 Stomach Neoplasms "RESULTS: A robust microRNA regulated network module was identified to characterize GC progression, which consisted of seven miR-200/183 family members, five mRNAs and two long non-coding RNAs H19 and CLLU1. CONCLUSIONS: Our strategy which combines AI-assisted bioinformatics method with experimental and clinical validation suggested that the miR-200/183 family-mediated network module as a ""pluripotent module"", which could be potential marker for GC progression." +circulation_biomarker_diagnosis_ns 36864077 hsa-mir-20a COVID-19 In the present study, serum MiRNA-106a and miRNA-20a were quantified by real time-PCR in 50 COVID-19 patients hospitalized at Minia university hospital and 30 healthy volunteers. +transcription factor target 36863315 hsa-mir-34a Inflammation Thus, miR-34a and senescent PDL cells might be promising therapeutic targets for periodontitis in elderly people. +other 36863142 hsa-mir-146a Osteoarthritis induced rabbit OA model was established to investigate the therapeutic role of miR-146a-5p in OA. +lncRNA target 36862865 hsa-mir-126 Carcinoma, Ovarian Epithelial Though in our previous study we found that miR-126 may inhibit proliferation and invasion in EOC cell lines, but in this study patients with elevated miR-126 expression exhibited poor overall survival and relapse free survival. +other 36862332 hsa-mir-1 Pancreatitis In addition, the method was also utilized to detect the miRNA-31 expression in collected clinical samples from pancreatitis patients and demonstrated that miRNA-31 was upregulated in patients, showing a great promising of the method in clinical application. +circulation_biomarker_diagnosis_ns 36862282 hsa-mir-940 Bulimia Nervosa The expression patterns of JHDM1D-AS1, miR-940 and ARTN in BC cells were altered by lentivirus infection and plasmid transfection for functional assays on the biological properties of BC cells. +other 36862282 hsa-mir-940 Breast Neoplasms In this study, we clarified the mechanistic understanding of JHDM1D-AS1-miRARTN ceRNA network in the development of breast cancer (BC). +genetics_overexpression_promote 36862227 hsa-mir-320c Cartilage Diseases METHODS: After 4 weeks of destabilization of the medial meniscus surgery (DMM) to establish an osteoarthritis model, the rats received weekly articular cavity injection of SMSCs with or without GW4869 treatment (exosome inhibitor) or exosomes from SMSCs with or without microRNA-320c overexpression for another 4 weeks. CONCLUSION: SMSC-derived exosomal microRNA-320c suppresses ECM degradation and chondrocyte apoptosis to facilitate cartilage damage repair in osteoarthritis rats by targeting ADAM19-dependent Wnt signalling. +genetics_overexpression_promote 36862227 hsa-mir-320c Osteoarthritis METHODS: After 4 weeks of destabilization of the medial meniscus surgery (DMM) to establish an osteoarthritis model, the rats received weekly articular cavity injection of SMSCs with or without GW4869 treatment (exosome inhibitor) or exosomes from SMSCs with or without microRNA-320c overexpression for another 4 weeks. CONCLUSION: SMSC-derived exosomal microRNA-320c suppresses ECM degradation and chondrocyte apoptosis to facilitate cartilage damage repair in osteoarthritis rats by targeting ADAM19-dependent Wnt signalling. +genetics_overexpression_promote 36862005 hsa-mir-483 Colorectal Neoplasms Taking advantage of a large panel of human metastatic colorectal cancer xenografts and matched stem-like cell cultures (m-colospheres), here we show that the overexpression of microRNA 483-3p (miRNA +genetics_knock down_promote 36861928 hsa-mir-497 Adenocarcinoma of Lung Also, LINC00511 and SMAD3 were overexpressed, while miR +target gene 36861798 hsa-mir-4660 Triple Negative Breast Neoplasms (R)-9bMS inhibited the protein synthesis and autophagy of triple negative breast cancer cells via regulating miR-4660/mTOR axis. +transcription factor target 36861382 hsa-mir-192 Diabetic Retinopathy 5p attenuates DR progression by targeting ELAVL1 and reducing PI3Kdelta expression, suggesting a biomarker for the treatment of DR. +circulation_biomarker_diagnosis_ns 36861291 hsa-mir-143 Arthritis 3p and cell factor generation in peripheral blood (PB) of RA sufferers were identified by ELISA or RT-qPCR. +genetics_overexpression_promote 36861149 hsa-mir-1256 Thyroid Cancer, Papillary Methods The expression of circ_0092315 in papillary thyroid carcinoma cells was examined by real-time fluorescence quantitative PCR.The proliferation and invasion of TPC-1 cells was assessed by CCK-8 and Transwell assays.The protein level of high mobility group A2 (HMGA2) was determined by Western blotting.The regulatory relationship of circ_0092315,microRNA-1256 (miR-1256),and HMGA2 was explored by bioinformatics tools,dual-luciferase reporter assay,real-time fluorescence quantitative PCR,and Western blotting. +++Results circ_0092315 was overexpressed in papillary thyroid carcinoma cells (all P<0.001).circ_0092315 promoted the proliferation and invasion of TPC-1 cells (all P<0.001).The transfection of si-circ_0092315 up-regulated the expression of miR-1256 (P<0.001),and miR-1256 inhibitor up-regulated the protein level of HMGA2 (P<0.001). +other 36860345 hsa-mir-21 Adenocarcinoma of Lung CONCLUSION: Hsa-mir-200a, hsa-mir-21, and hsa-mir-584 can serve as potential prognostic predictors in non-smoking females with LUAD. +other 36860345 hsa-mir-584 Adenocarcinoma of Lung CONCLUSION: Hsa-mir-200a, hsa-mir-21, and hsa-mir-584 can serve as potential prognostic predictors in non-smoking females with LUAD. +other 36860345 hsa-mir-200a Adenocarcinoma of Lung CONCLUSION: Hsa-mir-200a, hsa-mir-21, and hsa-mir-584 can serve as potential prognostic predictors in non-smoking females with LUAD. +circulation_biomarker_prognosis_ns 36860299 hsa-mir-486 Subarachnoid Hemorrhage The circulating exosomes miR +circulation_biomarker_prognosis_ns 36860299 hsa-mir-193b Subarachnoid Hemorrhage The circulating exosomes miR +circulation_biomarker_prognosis_ns 36860299 hsa-mir-410 Subarachnoid Hemorrhage The circulating exosomes miR +circulation_biomarker_prognosis_ns 36860299 hsa-mir-369 Subarachnoid Hemorrhage The circulating exosomes miR +other 36859458 hsa-mir-146a Plaque, Atherosclerotic We identified coordinately regulated miRNA-gene networks in which miR5p and miR-146a-5p are central hubs and miR-5001 and miR-7975 are potentially novel miRNAs associated with early atherosclerosis. +other 36859458 hsa-mir-5001 Plaque, Atherosclerotic We identified coordinately regulated miRNA-gene networks in which miR5p and miR-146a-5p are central hubs and miR-5001 and miR-7975 are potentially novel miRNAs associated with early atherosclerosis. +other 36859458 hsa-mir-17 Plaque, Atherosclerotic We identified coordinately regulated miRNA-gene networks in which miR5p and miR-146a-5p are central hubs and miR-5001 and miR-7975 are potentially novel miRNAs associated with early atherosclerosis. +transcription factor target 36859185 hsa-mir-4739 Breast Neoplasms Mechanically, BC069792 acts as a molecular sponge to adsorb hsa-miR-658 and hsa-miR-4739, to up-regulate the protein expression of Potassium Voltage-Gated Channel Q4 (KCNQ4), inhibits the activities of JAK2 and p-AKT, and plays a role in inhibiting breast cancer growth. +transcription factor target 36859185 hsa-mir-658 Breast Neoplasms Mechanically, BC069792 acts as a molecular sponge to adsorb hsa-miR-658 and hsa-miR-4739, to up-regulate the protein expression of Potassium Voltage-Gated Channel Q4 (KCNQ4), inhibits the activities of JAK2 and p-AKT, and plays a role in inhibiting breast cancer growth. +circulation_biomarker_diagnosis_ns 36859176 hsa-mir-155 Obesity The present study was designed to investigate expression patterns of miR-146a, miR-155, miR-15a, miR-193a, and miR-122 in peripheral blood mononuclear cells (PBMCs) in children who are obese along with their association with metabolic and inflammatory biomarkers. +circulation_biomarker_diagnosis_up 36858407 hsa-mir-155 Arthritis, Rheumatoid RESULTS: Compared with the normal group, the pain threshold was significantly decreased (P<0.05), and the knee circumference was significantly increased (P<0.05); the synovial tissue of knee joints showed significant hyperplasia, abundant blood flow signal, joint cavity effusion and obvious inflammatory invasion, the pathological score was significantly increased (P<0.05), the expressions of miR-155 mRNA and IL-1beta, IL-17A, TLR4, NF-kappaB p65 proteins were significantly increased (P<0.05), the expressions of SOCS1 mRNA and protein were significantly decreased (P<0.05) in the model group. +lncRNA target 36858024 hsa-mir-124 Brain Injuries, Traumatic Upregulation of miR-124 promoted the M2 polarization of microglia and inhibited the activity of TLR4 pathway, as well as reduced neuroinflammation and neurological deficit after TBI. +lncRNA target 36858024 hsa-mir-124 Parkinson Disease Upregulation of miR-124 promoted the M2 polarization of microglia and inhibited the activity of TLR4 pathway, as well as reduced neuroinflammation and neurological deficit after TBI. +other 36857620 hsa-mir-370 Endometrial Neoplasms 3p /MAPK1 axis. +genetics_overexpression_promote 36857196 hsa-mir-132 Colorectal Neoplasms 3p or overexpressing IGF2BP1 reversed such effects. +circulation_biomarker_diagnosis_ns 36856518 hsa-mir-27b Urinary Bladder Neoplasms 5p and miR-27b-3p were found differentially expressed in serum samples of bladder patients and healthy subjects. +circulation_biomarker_diagnosis_ns 36856518 hsa-mir-381 Urinary Bladder Neoplasms 5p and miR-27b-3p were found differentially expressed in serum samples of bladder patients and healthy subjects. +circulation_biomarker_diagnosis_ns 36856518 hsa-mir-451a Urinary Bladder Neoplasms 5p and miR-27b-3p were found differentially expressed in serum samples of bladder patients and healthy subjects. +lncRNA target 36856372 hsa-mir-30 Colorectal Neoplasms 5p/MAPK1 pathway, providing potential therapeutic targets for designing effective targeted treatments. +genetics_overexpression_suppress 36856212 hsa-mir-125b Osteosarcoma Modulation of miR-125b-5p and RAB3D levels produced opposite effects on proliferation and migration of osteosarcoma cells, and in cells with overexpression of both miR-125b-5p and RAB3D, the effect of RAB3D on cell proliferation and migration was blocked by miR-125b-5p overexpression (P < 0.05). +lncRNA target 36856205 hsa-mir-506 High Grade Ovarian Neoplasms 3p may affect EMT of ovarian cancer cells by regulating cell migration and invasion via SNAI2, and its expression level has predictive value for HGSOC recurrence. +transcription factor target 36856174 hsa-mir-12200 Osteoporosis, Postmenopausal The inhibition of miR5p would almost fully alleviate postmenopausal osteoporosis. +lncRNA target 36856174 hsa-mir-12200 Osteoporosis The inhibition of miR +transcription factor target 36856108 hsa-mir-503 Intervertebral Disc Degeneration CONCLUSIONS: miR-503 can improve the function and activity of human nucleus pulposus cells of degenerated intervertebral disc by inhibiting Wnt expression. +lncRNA target 36856073 hsa-mir-210 Fetal Hypoxia TET2-mtROS pathway and inhibition of STOCs and provides new insights into the understanding of uterine vascular maladaptation in pregnancy complications associated with gestational hypoxia. +lncRNA target 36856073 hsa-mir-210 Uterine Diseases Together, our study reveals a novel mechanistic link between the miRTET2-mtROS pathway and inhibition of STOCs and provides new insights into the understanding of uterine vascular maladaptation in pregnancy complications associated with gestational hypoxia. +lncRNA target 36856073 hsa-mir-210 Mitochondrial Diseases Hypoxia during pregnancy impairs uterine vascular adaptation via microRNA-210 (miR-210)-mediated mitochondrial dysfunction and mitochondrial reactive oxygen species (mtROS) generation. +transcription factor target 36855796 hsa-mir-590 Colonic Neoplasms After repressing miR3p with G4-CSSD590, the upregulation of CLCA1, B3GNT6 and UGT2A3 inhibited the proliferation and metastasis of colon cancer cells. +other 36855431 hsa-mir-150 Carcinoma, Hepatocellular CONCLUSION: ZFAS1 is associated with the malignant status and prognosis of patients with hepatocellular carcinoma, and the ZFAS1/miR5p axis is involved in hepatocellular carcinoma progression. +genetics_knock down_promote 36854894 hsa-mir-424 Cholangiocarcinoma 5p reversed the HCG18 knockdown induced suppression on cholangiocarcinoma cancer cells. +other 36854781 hsa-mir-194 Colorectal Neoplasms Our study suggests future evaluation of the functional role of SLC16A9 and hsa-mir5p and hsa-miR-378a-5p in CRC development. +other 36854781 hsa-mir-378a Colorectal Neoplasms Our study suggests future evaluation of the functional role of SLC16A9 and hsa-mir5p and hsa-miR-378a-5p in CRC development. +other 36854749 hsa-mir-200b Diabetes Mellitus Vasculogenic fibroblast subset emergence was blunted in delayed healing wounds of diabetic animals but, topical tissue nanotransfection of a single anti-miR-200b oligonucleotide was sufficient to restore FLI1 expression, vasculogenic fibroblast emergence, tissue perfusion, and wound healing. +other 36854749 hsa-mir-200b Wounds and Injuries Anti-miR-200b delivery to murine injury sites likewise enhanced tissue perfusion, wound closure, and vasculogenic fibroblast contribution to perfused vessels in a FLI1 dependent manner. Vasculogenic fibroblast subset emergence was blunted in delayed healing wounds of diabetic animals but, topical tissue nanotransfection of a single anti-miR-200b oligonucleotide was sufficient to restore FLI1 expression, vasculogenic fibroblast emergence, tissue perfusion, and wound healing. +transcription factor target 36853410 hsa-mir-21 Breast Neoplasms We demonstrate the assay with the detection of target miRNA-21 in total RNA extracted from MCF-7 cancer cells. +lncRNA target 36853001 hsa-mir-10b Pancreatitis, Chronic Evaluation of >170 clinical samples reveals that oncogenic microRNA-10b and tumor suppressor microRNA-let7a levels can individually differentiate PDAC from chronic pancreatitis and normal controls with >94% sensitivity and >94% specificity at a 95% confidence interval (CI). +lncRNA target 36853001 hsa-let-7a Pancreatic Carcinoma Evaluation of >170 clinical samples reveals that oncogenic microRNA-10b and tumor suppressor microRNA-let7a levels can individually differentiate PDAC from chronic pancreatitis and normal controls with >94% sensitivity and >94% specificity at a 95% confidence interval (CI). +lncRNA target 36853001 hsa-mir-10b Pancreatic Carcinoma Evaluation of >170 clinical samples reveals that oncogenic microRNA-10b and tumor suppressor microRNA-let7a levels can individually differentiate PDAC from chronic pancreatitis and normal controls with >94% sensitivity and >94% specificity at a 95% confidence interval (CI). +lncRNA target 36853001 hsa-let-7a Pancreatitis, Chronic Evaluation of >170 clinical samples reveals that oncogenic microRNA-10b and tumor suppressor microRNA-let7a levels can individually differentiate PDAC from chronic pancreatitis and normal controls with >94% sensitivity and >94% specificity at a 95% confidence interval (CI). +lncRNA target 36852954 hsa-mir-1 Myotonic Disorders Reduced levels of miR-1 and consecutive up-regulation of its target Mp/Col15A1 might be critical in DM1-associated DCM. +lncRNA target 36852954 hsa-mir-1 Dmd-Associated Dilated Cardiomyopathy Reduced levels of miR-1 and consecutive up-regulation of its target Mp/Col15A1 might be critical in DM1-associated DCM. +target gene 36852950 hsa-mir-485 Adenocarcinoma of Lung Circ_0070440 modulated LUAD malignant progression and ferroptosis via targeting SLC7A11, implying a significant role of the circ_0070440/miR-485-5p/SLC7A11 axis in the diagnosis and treatment of LUAD. +circulation_biomarker_diagnosis_up 36852944 hsa-mir-296 Coronary Disease RESULTS: Serum miR-296 was downregulated in CHD patients and was the lowest in patients with severe-CAS. +circulation_biomarker_diagnosis_down 36852944 hsa-mir-296 Coronary Artery Disease RESULTS: Serum miR-296 was downregulated in CHD patients and was the lowest in patients with severe-CAS. +other 36852928 hsa-mir-182 Carcinoma, Non-Small-Cell Lung 5p) were ruled out. +other 36852928 hsa-mir-96 Carcinoma, Non-Small-Cell Lung 5p) were ruled out. +other 36852928 hsa-mir-183 Carcinoma, Non-Small-Cell Lung 5p) were ruled out. +transcription factor target 36852907 hsa-mir-221 Diabetic Cardiomyopathies These data suggest that the protection of luteolin against DCM, at least, is related to suppressing JNK/c-Jun-regulated miR-221 and the subsequent blockage of autophagy. +genetics_overexpression_promote 36852794 hsa-mir-16 Glioblastoma 5p ablation and SEPT2 overexpression. +other 36852793 hsa-mir-155 Neuroblastoma erianin administration significantly decreased the expressions of hsa-miR-155-5p (P=0.014) and hsa-miR-223-3p (P=0.004) +other 36852793 hsa-mir-223 Neuroblastoma erianin administration significantly decreased the expressions of hsa-miR-155-5p (P=0.014) and hsa-miR-223-3p (P=0.004) +genetics_overexpression_promote 36852468 hsa-mir-613 Carcinoma, Renal Cell Furthermore, a rescue assay with AXL overexpression was performed to make a profound study whether miR-613 disturbs RCC proliferation, invasion, and migration through direct regulation of AXL. +lncRNA target 36852402 hsa-mir-3 Angelman Syndrome Given the miR-33's mechanistic relationships with multiple etiological factors in the pathogenesis of atherosclerosis (AS), we investigated the therapeutic potentials of dual-targeted microbubbles (HA-PANBs) in foam cell-specific release of anti-miR-33 (ANM33) oligonucleotides, resulting in the early prevention of AS progression and severity. +lncRNA target 36852402 hsa-mir-3 Fluoride Poisoning Given the miR-33's mechanistic relationships with multiple etiological factors in the pathogenesis of atherosclerosis (AS), we investigated the therapeutic potentials of dual-targeted microbubbles (HA-PANBs) in foam cell-specific release of anti-miR-33 (ANM33) oligonucleotides, resulting in the early prevention of AS progression and severity. +lncRNA target 36852302 hsa-mir-939 Colonic Neoplasms Moreover, Fusobacterium nucleatum promotes COAD progression through the miR3p/FUT1/MUC2 axis. +genetics_knock down_promote 36852074 hsa-mir-30 Stomach Neoplasms A hsa_circ_0072309 overexpression suppressed whereas a hsa_circ_0072309 knockdown promoted GC cells proliferation and migration in vitro; in addition, hsa_circ_0072309 could directly bind to has-miR-34a-3p and has-miR5p. +genetics_knock down_promote 36852074 hsa-mir-34a Stomach Neoplasms A hsa_circ_0072309 overexpression suppressed whereas a hsa_circ_0072309 knockdown promoted GC cells proliferation and migration in vitro; in addition, hsa_circ_0072309 could directly bind to has-miR-34a-3p and has-miR5p. +transcription factor target 36852042 hsa-mir-16 Neurogenic Inflammation It also regulates both neuroinflammation and serotoninergic neurotransmission through miRNAs, such as the miR-16. +transcription factor target 36852042 hsa-mir-16 Inflammation It also regulates both neuroinflammation and serotoninergic neurotransmission through miRNAs, such as the miR-16. +therapeutic target 36851875 hsa-mir-541 Thyroid Cancer, Papillary circNRIP1 can be a prognostic biomarker and therapeutic target for PTC by acting as a sponge for oncogenic miR-541-5p and miR-3064-5p to upregulate PKM2 expression. +circulation_biomarker_diagnosis_up 36851429 hsa-mir-126 Lymphoma However, oncogenic miR-18b and 20b were not elevated in any group and miR-126 and 214 were down-regulated in T-cell and B-cell lymphoma, as well as in carcinomas and lymphoplasmacytic enteritis of the small intestine. +other 36851429 hsa-mir-192 Lymphoma Expression of miR-18b and miR-192 was higher in carcinomas of the small intestine than in those of the large intestine. +circulation_biomarker_diagnosis_up 36851429 hsa-mir-18b Lymphoma However, oncogenic miR-18b and 20b were not elevated in any group and miR-126 and 214 were down-regulated in T-cell and B-cell lymphoma, as well as in carcinomas and lymphoplasmacytic enteritis of the small intestine. +therapeutic target 36848481 hsa-mir-372 Stomach Neoplasms downregulation of miR-372-5p may be assumed as a possible therapeutic target in treating gastric cancer. +lncRNA target 36848349 hsa-mir-942 Esophageal Squamous Cell Carcinoma 5p/CST1 axis might be a promising target for diagnosis and treatment of ESCC. +other 36848313 hsa-mir-19a Pulmonary Fibrosis Accordingly, blocking the secretion of IPF LF-derived EV miR-19a and their signaling pathways is a potential therapeutic strategy for managing IPF and lung cancer progression. +other 36848313 hsa-mir-19a Lung Neoplasms Accordingly, blocking the secretion of IPF LF-derived EV miR-19a and their signaling pathways is a potential therapeutic strategy for managing IPF and lung cancer progression. +lncRNA target 36848245 hsa-mir-27a Cholangiocarcinoma FoxO signalling was predominantly downregulated by miR-27a-3p in CCA, partially through targeting of FOXO1. +lncRNA target 36848007 hsa-mir-203a Parkinson Disease 5p], and transcription factors [specificity protein 1 (SP1), v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA), and nuclear factor Kappa B subunit 1 (NFKB1)], quercetin exhibited its neurotherapeutic effects in CI and PD. +lncRNA target 36848007 hsa-mir-16 Parkinson Disease 5p], and transcription factors [specificity protein 1 (SP1), v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA), and nuclear factor Kappa B subunit 1 (NFKB1)], quercetin exhibited its neurotherapeutic effects in CI and PD. +lncRNA target 36848007 hsa-mir-26b Parkinson Disease 5p], and transcription factors [specificity protein 1 (SP1), v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA), and nuclear factor Kappa B subunit 1 (NFKB1)], quercetin exhibited its neurotherapeutic effects in CI and PD. +lncRNA target 36848007 hsa-mir-335 Parkinson Disease 5p], and transcription factors [specificity protein 1 (SP1), v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA), and nuclear factor Kappa B subunit 1 (NFKB1)], quercetin exhibited its neurotherapeutic effects in CI and PD. +lncRNA target 36848007 hsa-mir-125b Parkinson Disease 5p], and transcription factors [specificity protein 1 (SP1), v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA), and nuclear factor Kappa B subunit 1 (NFKB1)], quercetin exhibited its neurotherapeutic effects in CI and PD. +genetics_knock down_suppress 36847916 hsa-mir-422a Osteoporosis Finally, since adipocytes released a higher amount of miR-422a in culture medium compared to hBMSCs we analyzed the levels of circulating miR-422a in patients with osteoporosis-a condition characterized by increased marrow adiposity-demonstrating that its levels are negatively correlated with T- and Z-scores. Overall, our findings suggest that miR-422a has a role in hBMSC adipogenesis by downregulating MeCP2 and its circulating levels are associated with bone mass loss in primary osteoporosis. +genetics_knock down_suppress 36847916 hsa-mir-422a Bone Diseases, Metabolic Overall, our findings suggest that miR-422a has a role in hBMSC adipogenesis by downregulating MeCP2 and its circulating levels are associated with bone mass loss in primary osteoporosis. +lncRNA target 36847717 hsa-mir-204 Sciatic Neuropathy In summary, HAGLR promoted SC proliferation, migration, neurotrophic factor production, and facilitated functional recovery of SNC rats via miR-204/CDK5R1. +other 36847693 hsa-mir-23b Uterine Cervical Neoplasms The HPV16 E6, E7/miR-23b-3p/ICAT signaling axis promotes proliferation, migration, invasion and EMT of cervical cancer cells. +genetics_overexpression_promote 36847222 hsa-mir-252 Wounds and Injuries Notably, co-overexpression of Rab6 completely rescued the wing phenotype associated with miR-252 overexpression, further supporting that Rab6 is a biologically relevant target of miR +other 36847199 hsa-mir-545 Aortic Aneurysm, Abdominal 3p/CKAP4 axis, adding further understanding of the pathogenesis of AAA and a potential therapeutic approach in AAA management. +other 36847071 hsa-mir-142 Colorectal Neoplasms LncRNA LINC01871 sponging miR-142-3p to modulate ZYG11B promotes the chemoresistance of colorectal cancer cells by inducing autophagy. +target gene 36846943 hsa-mir-152 Lung Neoplasms ELF1 suppresses autophagy to reduce cisplatin resistance via the miR-152-3p/NCAM1/ERK axis in lung cancer cells. +transcription factor target 36846934 hsa-mir-133b Carcinoma, Non-Small-Cell Lung CONCLUSIONS: miR-133b downregulates FOXL2 by targeting the 3'-UTR of FOXL2, thereby inhibiting cell proliferation, EMT and metastasis induced by the TGF-beta/Smad signaling pathway in NSCLC. +genetics_knock down_suppress 36846012 hsa-mir-188 Angelman Syndrome RASSF8-AS1 knockdown caused an increase in miR +other 36845968 hsa-mir-455 Osteoarthritis 3p in OA was downregulated, while PTEN was upregulated (P < 0.05) in comparison to healthy chondrocytes (P < 0.05). +target gene 36845963 hsa-mir-222 Breast Neoplasms MiR-221 and miR-222 regulate cell cycle progression and affect chemosensitivity in breast cancer by targeting ANXA3. +target gene 36845963 hsa-mir-221 Breast Neoplasms MiR-221 and miR-222 regulate cell cycle progression and affect chemosensitivity in breast cancer by targeting ANXA3. +other 36845957 hsa-mir-582 Obesity 5p-Elovl5 network may be disrupted in lipid metabolism and lead to obesity in the offspring of obese dams. +other 36845651 hsa-mir-103a-2 Amyotrophic Lateral Sclerosis 5p, and hsa-miR-181d-5p had a trend to be upregulated. +other 36845651 hsa-mir-181d Amyotrophic Lateral Sclerosis 5p, and hsa-miR-181d-5p had a trend to be upregulated. +other 36845651 hsa-mir-199a Amyotrophic Lateral Sclerosis 5p, and hsa-miR-181d-5p had a trend to be upregulated. +genetics_overexpression_promote 36845338 hsa-mir-186m Carcinoma, Non-Small-Cell Lung In vivo, endothelial miR-186 overexpression inhibited the vascularization of Matrigel plugs and the initial growth of tumors composed of NSCLC cells (NCI-H460) and HDMECs. +genetics_overexpression_promote 36845338 hsa-mir-186 Carcinoma, Non-Small-Cell Lung In vivo, endothelial miR-186 overexpression inhibited the vascularization of Matrigel plugs and the initial growth of tumors composed of NSCLC cells (NCI-H460) and HDMECs. +other 36845111 hsa-mir-30 Chilblain lupus 3p contributes to HBV immune escape, which may provide novel insights into the roles of interaction networks among lncRNA, miRNA, and mRNA in HBV immune escape, highlighting potential applications of lnc-AIFM2-1 and CD244 for diagnosis and treatment in CHB. +transcription factor target 36845016 hsa-mir-206 Hypertension, Renal CONCLUSION: By upregulating the expression of miR-205 and miR-206 in MVs secreted by EPC, the transcriptional activity of DDX5 and the activation of caspase-3/9 can be inhibited, thereby promoting the growth of PRKs and protecting the injury caused by hypertensive nephropathy. +transcription factor target 36845016 hsa-mir-205 Hypertension, Renal CONCLUSION: By upregulating the expression of miR-205 and miR-206 in MVs secreted by EPC, the transcriptional activity of DDX5 and the activation of caspase-3/9 can be inhibited, thereby promoting the growth of PRKs and protecting the injury caused by hypertensive nephropathy. +lncRNA target 36845011 hsa-mir-9a Ischemic Stroke PURPOSE: Present research is aimed at exploring the effect of miR-9a-5p on mitochondrial autophagy and alleviating cellular oxidative stress injury in ischemic stroke. CONCLUSION: miR-9a-5p protects against ischemic stroke by inhibiting OGD/R-induced mitochondrial autophagy and alleviating cellular oxidative stress injury. +exosome 36844871 hsa-mir-1 Stomach Neoplasms Our findings revealed that exosomal miR-31, miR-192, and miR-375 might serve as noninvasive, sensitive, and specific biomarkers for the diagnosis and prognosis of GC patients. +exosome 36844871 hsa-mir-375 Stomach Neoplasms Our findings revealed that exosomal miR-31, miR-192, and miR-375 might serve as noninvasive, sensitive, and specific biomarkers for the diagnosis and prognosis of GC patients. +target gene 36844868 hsa-mir-613 Carcinoma, Non-Small-Cell Lung Tumor Suppressor miR-613 Alleviates Non-Small Cell Lung Cancer Cell via Repressing M2 Macrophage Polarization. +exosome 36844629 hsa-mir-187 Breast Neoplasms Taxol-resistant breast cancer cell-derived exosome-delivered miR-187-5p regulates the growth of breast cancer cells via ABCD2 and Wnt/beta-catenin signaling. +genetics_GWAS 36843628 hsa-mir-26a Acute Coronary Syndrome This study aimed to determine the association between genetic (CYP2C19 and P2Y12 polymorphisms) and epigenetic (DNA methylation of CYP2C19 and P2Y12 and miRNA-26a expression) factors and their effects on MACEs among post-PCI patients. This study demonstrated that hypomethylation of CYP2C19 and miRNA-26a upregulation increased the risk of clopidogrel resistance in post-PCI patients, but there was no correlation between clopidogrel resistance and MACEs. +transcription factor target 36843205 hsa-mir-216a Arthritis, Rheumatoid These results revealed that the miR-216a-3p/DUSP5 pathway may play a crucial role in the malignant behavior of FLS, which may serve as a new target for the treatment of RA. +other 36842554 hsa-mir-339 Schizophrenia This study aimed to determine the Role of miRNA- 339-5p in the Regulation of Klotho Gene Expression and its Circulatory Levels in Schizophrenia. +lncRNA target 36841811 hsa-mir-130a Myocardial Reperfusion Injury Collectively, our findings suggest that miR-130a regulates FUNDC1-mediated mitophagy by targeting GJA1 in myocardial IRI. +lncRNA target 36841801 hsa-mir-506 Colorectal Neoplasms CONCLUSIONS: Our study showed that LINC00543 enhanced EMT of CRC cells through the pre-miR3p/FOXQ1 axis. +other 36841760 hsa-mir-15a Stomach Neoplasms Our study also included bioinformatics analyses which determined that the high expression of hsa_circ_0069382 regulated the BTG anti-proliferation factor 2 (BTG2)/ focal adhesion kinase (FAK) axis in gastric cancer lines by sponging for miR-15a-5p. +genetics_overexpression_promote 36841132 hsa-mir-519c Melanoma Finally, we showed restoration of miR-519c-3p in NEAT1-overexpressing SK-MEL-5 CDDP Res cells successfully overrode the NEAT1-promoted cisplatin resistance in melanoma from in vitro and in vivo results. +circRNA target 36840946 hsa-mir-421 Prostatic Neoplasms The rescue assay results for the PC3 and Du145 cell lines demonstrated that circDHRS3 inhibits prostate cancer cell lines' ability to proliferate and metastasize by modulating MEIS2 expression through the circDHRS3/miR-421/MEIS2 axis. Our study indicates that circDHRS3 inhibits prostate cancer cell proliferation and metastasis through the circDHRS3/miR-421/MEIS2 axis. +genetics_overexpression_promote 36840697 hsa-mir-431 Colorectal Neoplasms Additionally, miR-431 suppression or SLC7A11 overexpression overturned circSTIL silencing-mediated cell phenotypes in CRC cells. CircSTIL promotes CRC cell proliferation and suppresses ferroptosis in vitro via miR-431/SLC7A11 signaling, revealing the pathogenesis of CRC, and providing potential therapeutic targets of CRC. +genetics_overexpression_promote 36840487 hsa-mir-450b Liver Failure, Acute MDM2 overexpression reversed the repressive effects of elevated miR-450b-5p on ALF. +other 36840403 hsa-mir-146a Dengue These results suggest that miR5p and miR-146a-5p could be used as diagnostic and prognostic markers for dengue disease progression, in addition to the already available biochemical and pathological parameters. +other 36840403 hsa-mir-96 Dengue These results suggest that miR5p and miR-146a-5p could be used as diagnostic and prognostic markers for dengue disease progression, in addition to the already available biochemical and pathological parameters. +circulation_biomarker_diagnosis_ns 36836704 hsa-mir-172 Liver Injury 5p in serum EVs helped in predicting the progression of the NCs to severe liver injury-CHB, while the addition of EV miR +circulation_biomarker_diagnosis_ns 36836704 hsa-mir-1285 Liver Injury 5p in serum EVs helped in predicting the progression of the NCs to severe liver injury-CHB, while the addition of EV miR +circulation_biomarker_diagnosis_up 36836704 hsa-mir-335 Liver Injury 5p in serum EVs helped in predicting the progression of the NCs to severe liver injury-CHB, while the addition of EV miR +other 36836631 hsa-mir-194 Acquired Immunodeficiency Syndrome The aim of this study was to evaluate the expression of HNF1, HNF4, LXRb, and miRNAs (HNF4 specific: miR5p and miR-122(*)_1) that regulate CYP7A1 transcription in HIV-infected Black South African women on cART and presenting with gallstones relative to HIV-negative patients with gallstone disease. +other 36836631 hsa-mir-122 Acquired Immunodeficiency Syndrome The aim of this study was to evaluate the expression of HNF1, HNF4, LXRb, and miRNAs (HNF4 specific: miR5p and miR-122(*)_1) that regulate CYP7A1 transcription in HIV-infected Black South African women on cART and presenting with gallstones relative to HIV-negative patients with gallstone disease. +other 36835984 hsa-mir-146a Osteoarthritis TREM1, LIF, miR146-5a, and GAS5 were identified to be OA-related genes and potential regulatory pathways. +lncRNA target 36835852 hsa-mir-199a Chondrocyte Hypertrophy The intra-articular injection of synthetic miR-199a-5p agomir attenuated OA symptoms in rats, including the alleviation of articular cartilage destruction, subchondral bone degradation, and synovial inflammation. +lncRNA target 36835852 hsa-mir-199a Osteoarthritis The intra-articular injection of synthetic miR-199a-5p agomir attenuated OA symptoms in rats, including the alleviation of articular cartilage destruction, subchondral bone degradation, and synovial inflammation. +other 36835336 hsa-mir-155 Breast Neoplasms The pooled sensitivity and specificity of MIR21 for BC diagnosis were 0.86 (95%CI 0.76-0.93) and 0.84 (95%CI 0.71-0.92), 0.83 (95%CI 0.72-0.91) and 0.90 (95%CI 0.69-0.97) for MIR155, and 0.56 (95%CI 0.32-0.71) and 0.95 (95%CI 0.88-0.98) for MIR10b, respectively. +other 36835336 hsa-mir-21 Breast Neoplasms The pooled sensitivity and specificity of MIR21 for BC diagnosis were 0.86 (95%CI 0.76-0.93) and 0.84 (95%CI 0.71-0.92), 0.83 (95%CI 0.72-0.91) and 0.90 (95%CI 0.69-0.97) for MIR155, and 0.56 (95%CI 0.32-0.71) and 0.95 (95%CI 0.88-0.98) for MIR10b, respectively. +other 36835336 hsa-mir-10b Breast Neoplasms The pooled sensitivity and specificity of MIR21 for BC diagnosis were 0.86 (95%CI 0.76-0.93) and 0.84 (95%CI 0.71-0.92), 0.83 (95%CI 0.72-0.91) and 0.90 (95%CI 0.69-0.97) for MIR155, and 0.56 (95%CI 0.32-0.71) and 0.95 (95%CI 0.88-0.98) for MIR10b, respectively. +genetics_overexpression_promote 36835287 hsa-mir-193b Hyperglycemia Overexpression of hsa-miR-193b-3p under hyperglycemia also resulted in excess accumulation of intracellular lipid droplets in HepG2 cells. +circulation_biomarker_diagnosis_up 36835287 hsa-mir-193b Metabolic-Associated Fatty Liver Disease This study supports further research into potential use of microRNA hsa-miR-193b-3p as a possible clinically relevant plasma biomarker for metabolic-associated fatty liver disease (MAFLD) in dysglycemic context. +circulation_biomarker_prognosis_ns 36835272 hsa-mir-411 Atrial Fibrillation In conclusion, circulating miR5p could be a valuable prognostic biomarker for MACE in AF patients. +other 36835029 hsa-mir-21 Carcinoma, Pancreatic Ductal In this study, we focused on the expression of miR-21, -96, -196a, -210, and -217 in normal fibroblasts, cancer-associated fibroblasts prepared from a ductal adenocarcinoma of the pancreas, and pancreatic carcinoma cell lines. +other 36834999 hsa-mir-23a Infertility, Female Overall, our findings point to MEIS1 as a common transcription repressor of miR-23a and NORHA, and develop the miR-23a/NORHA axis into a small regulatory network regulating GC apoptosis and female fertility. +other 36834756 hsa-mir-21 Head and Neck Neoplasms Of all miRNAs assessed, only upregulation of miR-21 was consistently shown to be an independent predictor of poor prognosis and may thus serve as a prognostic biomarker in HNSCC. +circulation_biomarker_diagnosis_up 36834570 hsa-mir-21 Carcinoma, Hepatocellular Upregulation of plasma hsa-miR +other 36833398 hsa-mir-143 Coronary Artery Disease However, Has-miR-143 rs41291957 genotype did not show a clear correlation with the risk of CAD. +other 36833380 hsa-let-7a-1 Stomach Neoplasms Impact of pri-let-7a-1 rs10739971 for Gastric Cancer Predisposition in an Amazon Gastric cancer (GC) is the fifth most common type of cancer and the fourth leading cause of cancer death. +lncRNA target 36833372 hsa-mir-146a psoriasis 1 Here, we investigated the possible associations between the MIR146A rs2910164 and MIR155 rs767649 variants and the response to anti-TNF therapy in a Greek cohort of 103 CD and 100 PsO patients. We genotyped 103 CD patients and 100 PsO patients via the PCR-RFLP method, utilizing the de novo formation of a restriction site for the SacI enzyme considering the MIR146A rs2910164, while Tsp45I was employed for the MIR155 rs767649 variant. +lncRNA target 36833372 hsa-mir-155 Crohn Disease Here, we investigated the possible associations between the MIR146A rs2910164 and MIR155 rs767649 variants and the response to anti-TNF therapy in a Greek cohort of 103 CD and 100 PsO patients. We genotyped 103 CD patients and 100 PsO patients via the PCR-RFLP method, utilizing the de novo formation of a restriction site for the SacI enzyme considering the MIR146A rs2910164, while Tsp45I was employed for the MIR155 rs767649 variant. +lncRNA target 36833372 hsa-mir-146a Crohn Disease Here, we investigated the possible associations between the MIR146A rs2910164 and MIR155 rs767649 variants and the response to anti-TNF therapy in a Greek cohort of 103 CD and 100 PsO patients. We genotyped 103 CD patients and 100 PsO patients via the PCR-RFLP method, utilizing the de novo formation of a restriction site for the SacI enzyme considering the MIR146A rs2910164, while Tsp45I was employed for the MIR155 rs767649 variant. +lncRNA target 36833372 hsa-mir-155 psoriasis 1 Here, we investigated the possible associations between the MIR146A rs2910164 and MIR155 rs767649 variants and the response to anti-TNF therapy in a Greek cohort of 103 CD and 100 PsO patients. We genotyped 103 CD patients and 100 PsO patients via the PCR-RFLP method, utilizing the de novo formation of a restriction site for the SacI enzyme considering the MIR146A rs2910164, while Tsp45I was employed for the MIR155 rs767649 variant. +other 36833357 hsa-mir-223 Arthritis, Rheumatoid AIM: This study was undertaken with the aim to investigate the association of single nucleotide variants; namely, rs2292832, rs3746444, rs11614913, rs1044165, and rs767649 of MIR149, MIR499, MIR196, MIR223, and MIR155, respectively, with RA in the Pakistani population. +other 36833357 hsa-mir-149 Arthritis, Rheumatoid AIM: This study was undertaken with the aim to investigate the association of single nucleotide variants; namely, rs2292832, rs3746444, rs11614913, rs1044165, and rs767649 of MIR149, MIR499, MIR196, MIR223, and MIR155, respectively, with RA in the Pakistani population. +other 36833357 hsa-mir-196 Arthritis, Rheumatoid AIM: This study was undertaken with the aim to investigate the association of single nucleotide variants; namely, rs2292832, rs3746444, rs11614913, rs1044165, and rs767649 of MIR149, MIR499, MIR196, MIR223, and MIR155, respectively, with RA in the Pakistani population. +other 36833357 hsa-mir-499 Arthritis, Rheumatoid AIM: This study was undertaken with the aim to investigate the association of single nucleotide variants; namely, rs2292832, rs3746444, rs11614913, rs1044165, and rs767649 of MIR149, MIR499, MIR196, MIR223, and MIR155, respectively, with RA in the Pakistani population. +other 36833357 hsa-mir-155 Arthritis, Rheumatoid AIM: This study was undertaken with the aim to investigate the association of single nucleotide variants; namely, rs2292832, rs3746444, rs11614913, rs1044165, and rs767649 of MIR149, MIR499, MIR196, MIR223, and MIR155, respectively, with RA in the Pakistani population. +other 36831939 hsa-mir-21 Stomach Neoplasms In the present research work, the state-of-art label-free electrochemical genosensing platform was developed based on the hybridization process in the presence of [Fe(CN)(6)](3-/4-) as an efficient redox probe for sensitive recognition of the miRNA-21 in human gastric cell lines samples. +other 36831894 hsa-mir-425 Glioblastoma 5p showed the highest consistency in an upregulation in all three GSCs. +other 36831695 hsa-mir-92a Colorectal Neoplasms HNRNPA2B1-Mediated MicroRNA-92a Upregulation and Section Acts as a Promising Noninvasive Diagnostic Biomarker in Colorectal Cancer. +other 36831632 hsa-mir-21 Prostatic Neoplasms MiR-21 Is Induced by Hypoxia and Down-Regulates RHOB in Prostate Cancer. +other 36831624 hsa-mir-27a Breast Neoplasms This case control study reports significant association between BC patients, healthy controls with the polymorphic variants of PI3K C > T, AKT-1 G > A KLF 14 C > T, MDM4 A > G, miR-27a A > G, miR-196a-2 C > T genes (p < 0.05). Similarly, KLF 14-AA, MDM4-GA, miR27a-GG and miR-196a-CT gene variants were associated with the higher risk probability of BC and were strongly correlated with staging of the BC patients. +other 36831624 hsa-mir-196a Breast Neoplasms This case control study reports significant association between BC patients, healthy controls with the polymorphic variants of PI3K C > T, AKT-1 G > A KLF 14 C > T, MDM4 A > G, miR-27a A > G, miR-196a-2 C > T genes (p < 0.05). Similarly, KLF 14-AA, MDM4-GA, miR27a-GG and miR-196a-CT gene variants were associated with the higher risk probability of BC and were strongly correlated with staging of the BC patients. +other 36831545 hsa-mir-218 Lung Neoplasms CONCLUSION: Our study highlights the vital role of the miR5p/EGFR signaling pathway in arsenic-induced carcinogenesis and angiogenesis, which may be helpful for the treatment of lung cancer induced by chronic arsenic exposure in the future. +lncRNA target 36831485 hsa-mir-34a Colorectal Neoplasms We have previously identified p53 and its target miR-34a, as critical determinants of the effect of hypoxia on colorectal cancer (CRC). Here we characterized the XBP-1(S) transcription factor and its regulator IRE1A as direct, conserved miR-34a targets in CRC cells. +genetics_overexpression_promote 36831315 hsa-mir-181b-2 Malformations of Cortical Development, Group II As irradiation reduced the viability and proliferation of NSCs, whereas the overexpression of SOX21 restored the impaired cell viability and promoted the proliferation of NSCs, the findings suggest that the radiation-induced interaction of miR-181b3p with SOX21 may play dual roles in microglia and NSCs, respectively, leading to the impairment of brain neurogenesis. +circulation_biomarker_diagnosis_ns 36831306 hsa-mir-451a Atrial Fibrillation Receiver operating characteristic curve analysis showed that miR-451a in left atrium plasma could predict atrial fibrillation recurrence after pulmonary vein isolation. Our data suggest that miRNA-451a expression plays an important role in AF recurrence by controlling fibrosis and progression. +other 36831107 hsa-mir-1271 Thoracic Aortic Dissection CONCLUSIONS: The hsa_circ_0007386/miR5P/IGF1R/AKT axis may aggravate the progression of TAD by inducing VSMCs apoptosis. +other 36831100 hsa-mir-675 Breast Neoplasms 3p showed the maximal AUC of 1.000. +other 36831100 hsa-let-7 Breast Neoplasms This study aims to investigate the relative quantification of long non-coding RNA (lncRNA) H19, microRNA (miR) 675-5p, 675-3p, and miR-let 7 in breast cancer patients. +other 36830824 hsa-mir-28 Dry Eye Syndromes We previously reported anti-miR-328 therapy for dry eye disease (DED). +other 36830652 hsa-mir-106a familial chylomicronemia syndrome In non-CS-associated AP, miRNAs including hsa-miR-21, hsa-miR-146a, and hsa-miR-106a demonstrated a lower expression level as compared with the healthy control. +other 36830652 hsa-mir-106a Pancreatitis In non-CS-associated AP, miRNAs including hsa-miR-21, hsa-miR-146a, and hsa-miR-106a demonstrated a lower expression level as compared with the healthy control. +other 36830652 hsa-mir-21 Pancreatitis In non-CS-associated AP, miRNAs including hsa-miR-21, hsa-miR-146a, and hsa-miR-106a demonstrated a lower expression level as compared with the healthy control. +other 36830652 hsa-mir-21 familial chylomicronemia syndrome In non-CS-associated AP, miRNAs including hsa-miR-21, hsa-miR-146a, and hsa-miR-106a demonstrated a lower expression level as compared with the healthy control. +other 36830652 hsa-mir-146a Pancreatitis In non-CS-associated AP, miRNAs including hsa-miR-21, hsa-miR-146a, and hsa-miR-106a demonstrated a lower expression level as compared with the healthy control. +other 36830652 hsa-mir-146a familial chylomicronemia syndrome In non-CS-associated AP, miRNAs including hsa-miR-21, hsa-miR-146a, and hsa-miR-106a demonstrated a lower expression level as compared with the healthy control. +other 36829221 hsa-mir-421 Adenocarcinoma Of Esophagus Differential and qPCR analysis showed that miR-421, miR-550a-3p, and miR-550a-5p were highly expressed in the EAC tissues and cell lines. +other 36829221 hsa-mir-550a Adenocarcinoma Of Esophagus Differential and qPCR analysis showed that miR-421, miR-550a-3p, and miR-550a-5p were highly expressed in the EAC tissues and cell lines. +other 36829221 hsa-mir-550a-1 Adenocarcinoma Of Esophagus Differential and qPCR analysis showed that miR-421, miR-550a-3p, and miR-550a-5p were highly expressed in the EAC tissues and cell lines. +other 36829193 hsa-mir-204 Mucocutaneous Lymph Node Syndrome 5p-MMP CONCLUSION: To conclude, the five-gene signature and three ceRNA networks constructed in our study are of great value in the early diagnosis of KD and might help to elucidate our understanding of KD at the RNA regulatory level. +other 36829193 hsa-mir-524 Mucocutaneous Lymph Node Syndrome 5p-MMP CONCLUSION: To conclude, the five-gene signature and three ceRNA networks constructed in our study are of great value in the early diagnosis of KD and might help to elucidate our understanding of KD at the RNA regulatory level. +other 36829181 hsa-mir-182 Breast Neoplasms We identified a feedback loop with the composition of miR5p, CMTM7, CTNNA1, CTNNB1 (beta-catenin), and TCF3, which play essential roles in breast cancer progression. +other 36828974 hsa-mir-185 Diabetic Nephropathies For the first time, we identified circRNA_0017076 as a sponge for miR5p, which regulates STIM1 gene expression and is involved in RIF. +circulation_biomarker_diagnosis_ns 36827064 hsa-mir-17 Carcinoma, Non-Small-Cell Lung 5p levels are significantly increased in the circulating blood of NSCLC patients. +lncRNA target 36827049 hsa-mir-6785 Colorectal Neoplasms Our study identified and primarily validated the hsa_circ_0046430/miR5p/SRCIN1 regulatory axis impacted on CRC prognosis, suggesting novel biomarkers and therapeutic targets for CRC patients. +genetics_knock down_promote 36826778 hsa-mir-101 Thyroid Cancer, Papillary 3p, and overexpressed HMGB1 almost reverted the inhibitory impacts induced by miR +other 36826008 hsa-mir-146a Colonic Neoplasms Tumoral and adjacent normal tissue samples were obtained from 40 CC patients, and the expression of miR-29a, miR-146a, miR-215 and miR-449 were determined by qRT-PCR analysis. +other 36826008 hsa-mir-215 Colonic Neoplasms Tumoral and adjacent normal tissue samples were obtained from 40 CC patients, and the expression of miR-29a, miR-146a, miR-215 and miR-449 were determined by qRT-PCR analysis. +other 36826008 hsa-mir-29a Colonic Neoplasms Tumoral and adjacent normal tissue samples were obtained from 40 CC patients, and the expression of miR-29a, miR-146a, miR-215 and miR-449 were determined by qRT-PCR analysis. +genetics_knock down_promote 36825753 hsa-mir-5195 Ovarian Neoplasms 3p significantly suppressed cell proliferation, cell cycle G1/S transition, migration and invasion in OC cell lines (SKOV-3 and OVCAR3), while knockdown of miR +circulation_biomarker_diagnosis_up 36825718 hsa-mir-103 Osteoporosis METHODS: Plasma samples of 66 OP patients and 66 healthy controls were collected to prepare RNA samples, followed by RT-qPCR to detect the expression of circPRKCI and miR-103. +transcription factor target 36825546 hsa-mir-21 Breast Neoplasms miR-21 and TGF-beta expression levels showed upregulation in patients with BC and elevated miR-21/TGF-beta levels consistent with the BC stage. This study suggested that miR-21 and MEG-2 can be used as prospective diagnostic biomarkers and emphasized the crucible role of TGF-beta as therapeutic targets for BC. +transcription factor target 36825443 hsa-mir-339 Vasculitis 3p targets the 5'UTR of NFATc3 mRNA to increase the protein level of NFATc3, thereby aggravating the occurrence of vascular inflammation. +lncRNA target 36824247 hsa-mir-217 Asthma Meanwhile, functional assays and animal experiments demonstrated that lncRNA NEAT1 regulated GATA3 expression through sponge miR-217, thereby regulating Th1/Th2 balance in CD4+T cells in pediatric asthma. CONCLUSION: lncRNA NEAT1/miR-217/GATA3 axis may reveal the immunological mechanism of pediatric asthma, which has potential clinical application value in the future. +target gene 36824234 hsa-mir-885 Stomach Neoplasms Arsenic Trioxide Affects the Proliferation of Gastric Cancer Cells through MiR-885-5p/CDC73 Axis. +other 36823980 hsa-mir-5739 Muscular Diseases Importantly, abnormal expression of miR-5739 was detected in somatic cells derived from patients with congenital muscle disease. +lncRNA target 36823651 hsa-mir-525 Osteoarthritis CONCLUSIONS: LINC00313 inhibited the development of OA through regulating miR5p/GDF5 axis. +genetics_knock down_promote 36823512 hsa-mir-139 Carcinoma, Cutaneous, Squamous Cell 5p inhibition reversed the repressive effect of circ_0068631 knockdown on CSCC cell progression. +genetics_overexpression_promote 36820950 hsa-mir-26b Nasopharyngeal Carcinoma Differential analysis of miRNA dataset showed that the expression of miR-26b was significantly downregulated in NPC, in agreement with the validation results of nasopharyngeal carcinoma cell lines. MiR-26b downregulation leads to CEP135 overexpression and NF-kappaB pathway activation in NPC, which enhances proliferation, migration, and prevents apoptosis of nasopharyngeal carcinoma cells. +genetics_knock down_promote 36820067 hsa-mir-545 Carcinoma, Non-Small-Cell Lung circ_0000376 knockdown suppresses non-small cell lung cancer cell tumor properties by the miR-545-3p/PDPK1 pathway. +transcription factor target 36819593 hsa-mir-155 Irritable Bowel Syndrome 5p participated in the pathogenesis of IBS, at least in part by inhibiting CLDN1 and ZO-1 expression, indicating that miR +transcription factor target 36819582 hsa-mir-194 Squamous Cell Carcinoma of Head and Neck Also, hsa-miR5p was found to contribute to the poor prognosis of OSCC by regulating CHD4 and enhancing tumor anoikis resistance via the PI3K/AKT signaling pathway. +circulation_biomarker_diagnosis_ns 36819547 hsa-mir-21 Ischemic Stroke "5p"" was significantly decreased in the peripheral blood of hospital patients." +circulation_biomarker_diagnosis_ns 36819547 hsa-mir-548ar Ischemic Stroke "5p"" was significantly decreased in the peripheral blood of hospital patients." +circulation_biomarker_diagnosis_ns 36819547 hsa-mir-142 Ischemic Stroke "5p"" was significantly decreased in the peripheral blood of hospital patients." +circulation_biomarker_diagnosis_ns 36819541 hsa-mir-17 Myocardial Infarction 3p was negatively correlated with circ_0049271 in the AMI blood samples. +lncRNA target 36819499 hsa-mir-23a Ovarian Neoplasms lncRNA GAS5 also decreases OC progression by upregulating WT1 and attenuating miR-23a, suggesting that it could be an advantageous therapeutic target for OC intervention. +circulation_biomarker_diagnosis_ns 36818649 hsa-mir-107 Parkinson Disease 5p were elevated in bdsEVs and sEVs from plasma; in contrast, their expression levels were decreased in plasma of the rat model of PD. +circulation_biomarker_diagnosis_ns 36818649 hsa-mir-379 Parkinson Disease 5p were elevated in bdsEVs and sEVs from plasma; in contrast, their expression levels were decreased in plasma of the rat model of PD. +circulation_biomarker_diagnosis_ns 36818649 hsa-mir-103 Parkinson Disease 5p were elevated in bdsEVs and sEVs from plasma; in contrast, their expression levels were decreased in plasma of the rat model of PD. +circulation_biomarker_diagnosis_ns 36818649 hsa-mir-219a-2 Parkinson Disease 5p were elevated in bdsEVs and sEVs from plasma; in contrast, their expression levels were decreased in plasma of the rat model of PD. +exosome 36818289 hsa-mir-218 Dmd-Associated Dilated Cardiomyopathy Mechanistically, we identified the upregulation of miRNA5p in the DCM-Exos as a critical contributor to fibrogenesis. +target gene 36817669 hsa-mir-1286 Lung Neoplasms MiR-1286 inhibits lung cancer growth through aerobic glycolysis by targeting PKM2. +transcription factor target 36817393 hsa-mir-182 Graves Ophthalmopathy CONCLUSIONS: ELF3/miR-182/TSHR axis alleviated Graves' orbitopathy by inhibiting adipogenic differentiation. +lncRNA target 36816363 hsa-mir-27a Colorectal Neoplasms The direct targeting of miR-27a-3p by ADAMTS9-AS2 abrogated the latter's effect in CRC cells. +other 36816358 hsa-mir-107 Breast Neoplasms The PTEN/AKT signaling pathway may be regulated by miR-107 to limit breast cancer cell growth and increase apoptosis, which suggests that miR-107 may be exploited as a tumor marker for therapeutic therapy. +target gene 36816357 hsa-mir-155 Carcinoma, Hepatocellular LncRNA CASC2 Regulate Cell Proliferation and Invasion by Targeting miR-155/SOCS1 Axis in Hepatocellular Carcinoma. +genetics_overexpression_suppress 36815970 hsa-mir-191 Adenomyosis MIR503HG directly targeted miR-191 that was highly expressed in endometrial tissues derived from patients with AD. Collectively, overexpressed MIR503HG impeded the proliferation and migration of ESCs derived from endometrium of patients with AD, while promoting apoptosis via inhibition of the Wnt/beta-catenin pathway via targeting miR-191. +circulation_biomarker_diagnosis_up 36815956 hsa-mir-519d Coronary Artery Disease METHODS: The expression level of miR-22, miR-30c, miR-145, miR-519d, interleukin 6 (IL-6), and transforming growth factor beta (TGF-) was determined in peripheral blood mononuclear cells (PBMCs) from 46 patients with CAD and 39 healthy controls using real-time quantitative polymerase chain reaction (qPCR) assay. +lncRNA target 36815949 hsa-mir-137 Lupus Erythematosus, Systemic Furthermore, miR-137 inhibitor intervention induced healthy CD4+ T cell pyroptosis and apoptosis via mediating AMPK, whereas miR-137 mimic transfection into CD4+ T cells of SLE patients leads to opposite results. +genetics_GWAS 36815649 hsa-mir-34a Carcinoma, Non-Small-Cell Lung LncRNA MCM3AP-AS1 enhances cell invasion, migration and tumor formation in non-small cell lung cancer cells by epigenetic inhibition of miR-34a. +other 36815359 hsa-mir-195 Breast Neoplasms Recently, long noncoding RNA MIR497HG and its embedded miR-497 and miR-195 are proved to play significant roles in many types of human cancers, but their roles in tamoxifen-resistant breast cancer remain unknown. +other 36815359 hsa-mir-497 Breast Neoplasms Recently, long noncoding RNA MIR497HG and its embedded miR-497 and miR-195 are proved to play significant roles in many types of human cancers, but their roles in tamoxifen-resistant breast cancer remain unknown. +genetics_overexpression_promote 36815253 hsa-mir-665 Adenocarcinoma of Lung PTPRB overexpression offsets the pro-proliferative potential of miR-665 in LUAD cells. +other 36814857 hsa-mir-124 Periodontitis The study was designed to examine the role of lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and miRNA-124 in the differentiation of osteoclasts, to provide new clues or evidences for the pathogenesis of periodontitis. +other 36814556 hsa-mir-24 Nasopharyngeal Carcinoma 3p/GAD1 axis is converged to modulate the growth, migration, and invasion of NPC cells. +target gene 36814555 hsa-mir-4757 Lung Neoplasms miR-4757-3p Inhibited the Migration and Invasion of Lung Cancer Cell via Targeting Wnt Signaling Pathway. +other 36814316 hsa-let-7f Schimke immunoosseous dysplasia Moreover, we found that SI gammadelta T cells shaped the gut microbiota and regulated intestinal homeostasis by secreting the fecal micro-RNA let-7f. +lncRNA target 36814156 hsa-mir-141 Prostatic Neoplasms 3p suppressed the tumor growth of PCa in vivo. +lncRNA target 36814152 hsa-mir-361 Alzheimer Disease In conclusion, silence of GATA4 ameliorated cognitive dysfunction and inhibited hippocampal inflammation and cell apoptosis through regulation of Sp1/SNHG1/miR3p. +lncRNA target 36813149 hsa-mir-199a Stomach Neoplasms The conspicuously increased expression of DDR2 was found in GC cell lines, luciferase reporter assays verified that miR-199a-3p directly targeted DDR2 gene, which was correlated to tumor progression. CONCLUSION: Phenotype screens and disseminated verifications incriminating in GC exposit the miR-199a-3p-DDR2-mTOR-SOX2 axis as a clinically actionable target for tumor PM progression. +genetics_knock down_promote 36813147 hsa-mir-146b Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: Our results revealed that CAF-derived exosomes contained higher levels of miR-146b-5p than NFs, and miR-146b-5p overexpression in exosomes promoted the malignant phenotype of OSCC by targeting HIPK3. +other 36813098 hsa-mir-1 Li-Fraumeni Syndrome In addition, we found a positive association between miRNA3p and LF (beta = 0.039, 95% CI = 0.002, 0.080). +transcription factor target 36812841 hsa-mir-124 Pneumonia 3p or activation of the p38MAPK pathway reversed the alleviative effect of CGA on pneumonia in vitro. +lncRNA target 36812568 hsa-mir-4299 Triple Negative Breast Neoplasms CONCLUSION: In general, the findings suggest that lncRNA AC093850.2 was closely related to the prognosis and progression of TNBC by sponging miR-4299, which might be a prognosis predictor and potential target for treating TNBC patients. +other 36812225 hsa-mir-155 Sepsis 5p, could be useful biomarkers for detecting sepsis. +other 36811957 hsa-mir-181c Squamous Cell Carcinoma of Head and Neck Meanwhile, circFNDC3B sequestered miR-181c-5p to upregulate SERPINE1 and PROX1, which drove epithelial-mesenchymal transition (EMT) or partial-EMT (p-EMT) in OSCC cells and promoted lymphangiogenesis to accelerate lymph node metastasis. +other 36811541 hsa-mir-34a Neuroblastoma 5p expression involved in regulating p53-mediated pathway are also considered. +other 36811541 hsa-mir-137 Neuroblastoma 5p expression involved in regulating p53-mediated pathway are also considered. +other 36811533 hsa-mir-125b-2 Breast Neoplasms Patients with a luminal BC showing higher levels of miR-125b-2 and miR-320a expression before therapy demonstrated better response to NHT with tamoxifen. CONCLUSIONS: The high levels of miR-125b-2, -155, -221, and -320a in tumor tissue are associated with the HER2/neu-positive status of luminal BC subtypes. +target gene 36811283 hsa-mir-6838 Breast Neoplasms Circ_0001667 accelerates breast cancer proliferation and angiogenesis through regulating CXCL10 expression by sponging miR-6838-5p. +epigenetics 36811277 hsa-mir-92a Pancreatic Carcinoma Taken together, our data suggest that targeting DNA methylation and miR-92a-3p-mediated repression of HIP1R could serve as novel therapeutic strategies for PAAD treatment. +lncRNA target 36811210 hsa-mir-625 Carcinoma, Hepatocellular 3p/PDLIM5 axis inhibits the development of HCC. +genetics_knock down_promote 36811106 hsa-mir-106a Laryngeal Neoplasms The migration and invasion ability of the LC cells was decreased after the miR-106a-5p knockdown. +circulation_biomarker_diagnosis_down 36810972 hsa-mir-1184 Myocardial Infarction In AMI serum, circHSPG2 and MAP3K2 mRNA were highly expressed and miR-1184 was down-regulated. +other 36810892 hsa-mir-105 Glioma 5p were identified as the most potential upstream miRNAs of REST in glioma patient cohort and experiments in vitro. +other 36810892 hsa-mir-9 Glioma 5p were identified as the most potential upstream miRNAs of REST in glioma patient cohort and experiments in vitro. +exosome 36810326 hsa-mir-204 Glioblastoma 3p tends to be sorted into exosomes. +transcription factor target 36810285 hsa-mir-17 Colorectal Neoplasms 5p contributes to chemotherapy sensitivity in CRC via m(6)A modification is unclear. +lncRNA target 36809926 hsa-mir-101 Transfusion Reaction Inhibition of miR +lncRNA target 36809926 hsa-mir-101 Hepatitis A Inhibition of miR +lncRNA target 36809926 hsa-mir-101 Aortic Valve Disease The finding is important as it reveals that miR-1013p may be a potential therapeutic target for calcific aortic valve disease. +genetics_overexpression_suppress 36809792 hsa-mir-23a Polycystic Ovary Syndrome RESULTS: miR-23a-3p was poorly expressed but HMGA2 was overexpressed in GCs of patients with PCOS. +transcription factor target 36809604 hsa-mir-483 Meningioma CONCLUSION: Meningioma cell growth is critically dependent on autocrine miR-483/IGF-2 stimulation and the IGF-2 pathway provides a feasible meningioma treatment target. +genetics_overexpression_promote 36809521 hsa-mir-194 Osteosarcoma HK2 overexpression weakened the inhibiting impacts of miR +transcription factor target 36809070 hsa-mir-29b-2 Respiratory Distress Syndrome In the current study, we provide evidence that AhR activation can attenuate LPS-mediated ARDS through the activation of Th22 cells in the lungs, which are regulated through miR-29b5p. +lncRNA target 36808502 hsa-mir-499 familial febrile seizures 1 It also upregulated SIRT1/PGC-1alpha/Nrf1/TFAM profiles at both gene and protein levels, Mfn2 protein, and microRNA-499 expression, and downregulated Drp1 protein and Beclin1, LC3, and p62 genes (P < .05 to P < .001). Co-application of NMN/melatonin within the setting of I/R injury in the aged rat heart induced noticeable cardioprotection through modulation of a coordinated network including microRNA-499 expression along with mitochondrial biogenesis associated with SIRT1/PGC-1alpha/Nrf1/TFAM profiles, mitochondrial fission/fusion, and autophagy, therefore, appears to prevent the burden of myocardial I/R injury in elderly patients. +transcription factor target 36808485 hsa-mir-3529 Adenocarcinoma of Lung The underlying mechanism may be that MSA alleviates hypoxia and has synergistic effects in cellular ROS promotion with miR +other 36808381 hsa-mir-34a Fibrosis In conclusion, our study indicated that the p53/miR-34a axis promotes the development of renal fibrosis. +genetics_knock down_promote 36808302 hsa-mir-579 gastric adenocarcinoma Accordingly, cell proliferation, cholesterol synthesis and SQLE expression were significantly inhibited by circ_0000182 knockdown in STAD cells, and these effects were partly reversed by miR +lncRNA target 36808266 hsa-mir-1249 Carcinoma, Non-Small-Cell Lung In vivo assay showed that circ_0001715 promoted the NSCLC progression through the miR +other 36807979 hsa-mir-122 Hepatitis C Efficient hepatitis C virus (HCV) RNA accumulation is dependent upon interactions with the human liver-specific microRNA, miR-122. +lncRNA target 36807469 hsa-mir-138 Stomach Neoplasms 5p/PLAGL2 molecular signaling axis in GC, and our findings provide enlightenment for further understanding of the mechanism of tumorigenesis and development of GC, making LGALS8-AS1 a possible new diagnostic or therapeutic target for GC. +circRNA target 36807271 hsa-mir-1205 Breast Neoplasms The expression of circ_0137652, miR-1205, and CCNB1 in BC tissues and cell lines were detected using RT-qPCR and/or western blotting. Furthermore, miR-1205 inhibits BC progression by targeting CCNB1. +lncRNA target 36806318 hsa-mir-200b Carcinoma, Non-Small-Cell Lung Furthermore, LncRNA ATB depletion suppressed NSCLC cells proliferation, migration and invasion, while miR-200b inhibitor or pcDNA-FN1 rescued these effects. CONCLUSION: In summary, our outcomes elucidated that LncRNA ATB/miR-200b axis expedited NSCLC cells proliferation, migration and invasion by up-regulating FN1. +lncRNA target 36806251 hsa-mir-525 Osteoarthritis 5p/HO-1 signaling pathway that may act to relieve OA by alleviating oxidative stress and regulating the NF-kappaB pathway, resulting in the protection of the ECM in human chondrocytes, highlighting it as a potential therapeutic target for the treatment of OA. +transcription factor target 36806218 hsa-mir-144 Carcinoma, Hepatocellular 3p/FOXK1 axis repressed malignant progression of HCC via affecting the aerobic glycolytic process of HCC cells. +lncRNA target 36806197 hsa-mir-187 Embryo Loss In contrast, NORFA, a functional lncRNA associated with sow follicular atresia and GC apoptosis, enhances miR-187 and TGFBR2 expression by inhibiting NORHA and activating NFIX. +lncRNA target 36806197 hsa-mir-187 Anovulation miR-187, a miRNA down-regulated during follicular atresia in sows, maintains TGFBR2 mRNA stability in sow GCs by directly binding to its 5'-UTR. In contrast, NORFA, a functional lncRNA associated with sow follicular atresia and GC apoptosis, enhances miR-187 and TGFBR2 expression by inhibiting NORHA and activating NFIX. +other 36806086 hsa-mir-29a Prostatic Neoplasms These findings proved that the important role of miR-29a-5p in prostate cancer ferroptosis. +other 36805538 hsa-mir-183 Stomach Neoplasms p-regulation of microRNA-183 reduces FOXO1 expression in gastric cancer patients with Helicobacter pylori infection. +transcription factor target 36805456 hsa-mir-23b Arthritis, Rheumatoid Following the intravenous injection of FP/miR-23b nanoparticles in experimental RA models, the nanoparticles show therapeutic efficacy with inhibition of inflammatory response, reduced bone and cartilage erosion, suppression of synoviocyte infiltration and the recovery of mobility. +other 36804532 hsa-mir-455 Pneumonia, Mycoplasma Bioinformatics analysis confirmed that decidual stromal cells derived from PE patients expressed significantly lower miR3p than those derived from healthy donors. +target gene 36804476 hsa-mir-10a Colorectal Neoplasms Novel splice variants of LINC00963 suppress colorectal cancer cell proliferation via miR-10a/miR-143/miR-217/miR-512-mediated regulation of PI3K/AKT and Wnt/β-catenin signaling pathways. +target gene 36804476 hsa-mir-217 Colorectal Neoplasms Novel splice variants of LINC00963 suppress colorectal cancer cell proliferation via miR-10a/miR-143/miR-217/miR-512-mediated regulation of PI3K/AKT and Wnt/β-catenin signaling pathways. +target gene 36804476 hsa-mir-512 Colorectal Neoplasms Novel splice variants of LINC00963 suppress colorectal cancer cell proliferation via miR-10a/miR-143/miR-217/miR-512-mediated regulation of PI3K/AKT and Wnt/β-catenin signaling pathways. +exosome 36804284 hsa-mir-20b Brain Injuries, Traumatic Furthermore, high level of microglial exosomal miR-20b-5p induced by mild hypothermia could transfer into injured neurons and promote neurite outgrowth and synapse recovery after TBI via activating the PI3K-AKT pathway by suppressing PTEN expression. +other 36803590 hsa-mir-192 Myelodysplastic Syndromes CONCLUSIONS: This study shows that high levels of miR5p are associated with higher overall survival and leukemia-free survival in myelodysplastic syndromes responding to azacitidine and lenalidomide. +other 36803590 hsa-mir-192 Leukemia 5p are associated with higher overall survival and leukemia-free survival in myelodysplastic syndromes responding to azacitidine and lenalidomide. +other 36802524 hsa-mir-155 Breast Neoplasms Furthermore, the biosensor could discriminate breast cancer patients evidently by analyzing exomiR-155, and these results conformed to that of qRT-PCR. +genetics_knock down_suppress 36802224 hsa-mir-1236 Pneumonia CONCLUSION: Circ_0099188 knockdown might mitigate LPS-induced HPAEpiC cell injury by targeting the miR3p/HMGB3 axis, providing an underlying therapeutic strategy for pneumonia treatment. +lncRNA target 36801666 hsa-mir-4731 Breast Neoplasms CONCLUSION: Collectively, BCSCs-EVs-mediated delivery of ARRDC1-AS1 may promote the malignant phenotypes of BC cells via the miR +other 36801567 hsa-mir-16 Cardiomegaly In humans, on the other hand, the level of miR-15a-5p and miRp was negatively associated with the severity of cardiac hypertrophy. +other 36801567 hsa-mir-15a Cardiomegaly In humans, on the other hand, the level of miR-15a-5p and miRp was negatively associated with the severity of cardiac hypertrophy. +lncRNA target 36801509 hsa-mir-539 Colorectal Neoplasms Mechanistically, we found that TP73-AS1 targeted miR +lncRNA target 36801505 hsa-mir-877 Breast Neoplasms In summary, TRG-AS1 acts an endogenous RNA, inhibited breast cancer bone metastasis by competitively binding with miR5p to upregulate WISP2 expression. +circulation_biomarker_prognosis_up 36801489 hsa-mir-132 Epilepsy 3p serum levels performed better than each separately as a diagnostic biomarker to distinguish epilepsy patients from controls. +lncRNA target 36801480 hsa-mir-34a Bone-Associated Metastatic Breast Cancer MicroRNA-34a (miRNA-34a) is a promising anti-cancer miRNA for gene therapy to bone metastatic cancer patients. The results of experiments in vitro and in vivo confirmed that the constructed bone-targeted miRNA delivery system PCA/miR-34a can enhance the anti-tumor efficacy in bone metastatic cancer, and provide a potential strategy for gene therapy in bone metastatic cancer. +circRNA target 36801359 hsa-mir-344 Anxiety Disorders 5p might be new targets for the treatment of stress-related disorder. +other 36801359 hsa-mir-344 Memory Disorders And miR5p mimics could simulate the dendritic spine density reduction, depressive- and anxiety-like behaviors and memory impairment induced by CUMS. +circRNA target 36801359 hsa-mir-344 Stress Disorders, Traumatic These findings represent the first evidence for the involvement of circSYNDIG1 and its coupling mechanism in depression and anxiety, suggesting that circSYNDIG1 and miR5p might be new targets for the treatment of stress-related disorder. +circRNA target 36801359 hsa-mir-344 Neurotic Disorders 5p might be new targets for the treatment of stress-related disorder. +lncRNA target 36800936 hsa-mir-181a Squamous Cell Carcinoma of Head and Neck Moreover, upregulated miR-181a-5p significantly inhibited OSCC cell proliferation, colony formation, invasion, and migration; blocked the cell cycle; and promoted apoptosis. +other 36800843 hsa-mir-199a Diabetic Nephropathies Urinary miR-199a-3p significantly (p<0.0001) downregulated in diabetic and lupus nephropathy prior to transplantation and significantly upregulated post-transplantation compared to the control. +other 36800843 hsa-mir-199a Lupus Nephritis Urinary miR-199a-3p significantly (p<0.0001) downregulated in diabetic and lupus nephropathy prior to transplantation and significantly upregulated post-transplantation compared to the control. +other 36800843 hsa-mir-155 Lupus Nephritis Urinary miR-199a-3p and miR5p expression levels in 72 adults with diabetic nephropathy and, 42 adults with lupus nephropathy renal transplant recipients. +other 36800843 hsa-mir-155 Diabetic Nephropathies Urinary miR-199a-3p and miR5p expression levels in 72 adults with diabetic nephropathy and, 42 adults with lupus nephropathy renal transplant recipients. +other 36800833 hsa-mir-223 Sepsis 3p can serve as potential biological indicators for predicting sepsis secondary to pneumonia. +other 36800833 hsa-mir-7110 Sepsis 3p can serve as potential biological indicators for predicting sepsis secondary to pneumonia. +other 36800817 hsa-mir-193a Endometrial Neoplasms 3p, miR-193a-3p and miR-193a-5p are low expressed in the cancer tissues of endometrial cancer patients and are related to the adverse clinicopathological parameters of patients. +other 36800817 hsa-mir-128 Endometrial Neoplasms 3p, miR-193a-3p and miR-193a-5p are low expressed in the cancer tissues of endometrial cancer patients and are related to the adverse clinicopathological parameters of patients. +other 36800601 hsa-mir-5703 Adenocarcinoma of Lung miR-5703, miR-3125, miR5P, and miR-513c-5p may be new biomarkers for the treatment of lung adenocarcinoma. +other 36800601 hsa-mir-652 Adenocarcinoma of Lung miR-5703, miR-3125, miR5P, and miR-513c-5p may be new biomarkers for the treatment of lung adenocarcinoma. +other 36800601 hsa-mir-3125 Adenocarcinoma of Lung miR-5703, miR-3125, miR5P, and miR-513c-5p may be new biomarkers for the treatment of lung adenocarcinoma. +other 36800601 hsa-mir-513c Adenocarcinoma of Lung miR-5703, miR-3125, miR5P, and miR-513c-5p may be new biomarkers for the treatment of lung adenocarcinoma. +lncRNA target 36800052 hsa-mir-450b Osteoporosis IRF-1 promoted the osteogenic differentiation via mediation of lncRNA XIST/miR-450b/FBXW7 axis, and this finding might shed novel insights on exploring new ideas against osteoporosis. +other 36799446 hsa-mir-125b Liver Cirrhosis In vitro, SCT 5-27 treatment of a human biliary PSC cell line decreased proliferation and senescence and SR/TGF-beta1/VEGF-A axis but increased the expression of miR-125b and FoxA2. +genetics_overexpression_promote 36799424 hsa-mir-940 Uterine Cervical Neoplasms RESULTS: Hsa_circ_0000021 and KPNA2 were overexpressed and inversely associated with the levels of miR +genetics_overexpression_promote 36799154 hsa-mir-29a Glioma By conducting hypoxia experiments in vitro on U251 glioma cells, it was found that the expression level of miR29a3p decreased following hypoxia, while overexpression of miR29a3p significantly decreased the proliferation of U251 glioma cells and promoted apoptosis by inhibiting the expression of the antiapoptotic marker Bcl2 and increasing the expression of the proapoptotic marker Bax The potential targets of miR29a3p were predicted by online tools and validated by a dualluciferase gene reporter assay. +other 36798914 hsa-mir-29a Diabetic Nephropathies RESULTS: Intravenous injections of KTCs-CM significantly reduced the urine volume, protein 24-h, BUN, and Scr, decreased the miRNA-377, and increased miRNA-29a and AQP1 in DN treated with CM rats. +other 36798914 hsa-mir-377 Diabetic Nephropathies RESULTS: Intravenous injections of KTCs-CM significantly reduced the urine volume, protein 24-h, BUN, and Scr, decreased the miRNA-377, and increased miRNA-29a and AQP1 in DN treated with CM rats. +other 36798788 hsa-mir-122 Colorectal Neoplasms 3p) were identified as common DEMs in GSE56350 and GSE73178 datasets. +other 36798788 hsa-mir-95 Colorectal Neoplasms 3p) were identified as common DEMs in GSE56350 and GSE73178 datasets. +other 36798788 hsa-mir-204 Colorectal Neoplasms 3p) were identified as common DEMs in GSE56350 and GSE73178 datasets. +other 36798788 hsa-mir-552 Colorectal Neoplasms 3p) were identified as common DEMs in GSE56350 and GSE73178 datasets. +other 36798467 hsa-mir-200 Brain Neoplasms However, currently, there is no known therapeutic role for miR-200 family members in the setting of BM. +circulation_biomarker_diagnosis_ns 36798431 hsa-mir-21 Pancreatic Carcinoma Here, we refined the original method by simultaneously measuring the serum miR5p level to enhance the detection of PDAC. +genetics_knock down_promote 36797846 hsa-mir-1299 Esophageal Squamous Cell Carcinoma All experimental data showed that knockdown of circPPFIA1 contributed to radiosensitivity in ESCC by inducing miR +genetics_overexpression_promote 36797791 hsa-mir-128 Stomach Neoplasms Overexpressed TUFT1 reduced miR +other 36797674 hsa-mir-758 Migraine Disorders 5p) novel signature has been found differentially expressed between controls and patients with migraine. +other 36797674 hsa-mir-342 Migraine Disorders 5p) novel signature has been found differentially expressed between controls and patients with migraine. +genetics_knock down_promote 36797317 hsa-mir-1270 Pancreatic Carcinoma The repressive effects of NR3C1 knockdown on PC cell malignant phenotypes were partly abolished by miR-1270 inhibition. +genetics_overexpression_promote 36796652 hsa-mir-125b Glioma Mechanistic studies revealed that circ101491 upregulated EDN1 expression through sponging miR-125b-5p, thus facilitating glioma progression. In summary, hypoxia could promote circ101491 overexpression in glioma cell-derived exosomes, and circ101491/miR-125b-5p/EDN1 regulatory axis might be implicated in the malignant progression of glioma. +lncRNA target 36796622 hsa-mir-1278 Glioma These findings display that circPKD2 can function as a tumor suppressor in glioma by controlling the miR-1278/LATS2 axis and provide the potential biomarkers for glioma treatment. +lncRNA target 36796497 hsa-mir-214 Nephritis, Interstitial 3p attenuates T-2 toxin-induced chondrocyte apoptosis and ECM degradation through a potential NF-kappaB signaling pathway. +genetics_overexpression_promote 36796259 hsa-mir-149 psoriasis 1 CONCLUSION: The overexpressed miR +other 36795778 hsa-mir-489 Diabetic Retinopathy CONCLUSION: This study demonstrated that a TPTEP1/miR3p/NRF2 axis affects the development of DR by regulating oxidative stress. +transcription factor target 36795153 hsa-mir-18a Brain Injuries Through this mechanism, transfer of miR-18a-5p by MSC-EVs contributed to the eventual inhibition of early brain injury and neurological impairment following SAH. +transcription factor target 36795153 hsa-mir-18a Subarachnoid Hemorrhage Through this mechanism, transfer of miR-18a-5p by MSC-EVs contributed to the eventual inhibition of early brain injury and neurological impairment following SAH. +lncRNA target 36794620 hsa-mir-499a Colorectal Neoplasms Additionally, METTL14 restrains aerobic glycolysis in p53-WT CRC, by repressing SLC2A3 and PGAM1 expression via selectively promoting m(6) A-YTHDF2-dependent pri-miR-6769b/pri-miR-499a processing. +lncRNA target 36794620 hsa-mir-6769b Colorectal Neoplasms Additionally, METTL14 restrains aerobic glycolysis in p53-WT CRC, by repressing SLC2A3 and PGAM1 expression via selectively promoting m(6) A-YTHDF2-dependent pri-miR-6769b/pri-miR-499a processing. +other 36794154 hsa-mir-155 Chronic Disease Conclusion: IL-10 downregulated miR-155 and activated SOCS5, thereby promoting macrophage M2 polarization to relieve chronic rejection after heart transplantation. +other 36793717 hsa-mir-25 Tuberculosis 3p) that might participate in the pathogenesis of tuberculosis were screened out by constructing a miRNA-mRNA pathway regulatory network. +other 36793717 hsa-mir-150 Tuberculosis 3p) that might participate in the pathogenesis of tuberculosis were screened out by constructing a miRNA-mRNA pathway regulatory network. +other 36793496 hsa-mir-34c Colorectal Neoplasms The expression of has-miR-34c (P = 0.036), hsa-miR-320a (P = 0.045), and has-miR-338 (P = 0.0063) was correlated with the prognosis of CRC patients. +other 36793496 hsa-mir-20a Colorectal Neoplasms The expression of has-miR-34c (P = 0.036), hsa-miR-320a (P = 0.045), and has-miR-338 (P = 0.0063) was correlated with the prognosis of CRC patients. +other 36793496 hsa-mir-338 Colorectal Neoplasms The expression of has-miR-34c (P = 0.036), hsa-miR-320a (P = 0.045), and has-miR-338 (P = 0.0063) was correlated with the prognosis of CRC patients. +exosome 36793374 hsa-mir-370 Uterine Cervical Neoplasms The positive feedback loop of exosomal MALAT1/miR-370-3p/STAT3 mediates the cisplatin resistance of cervical cancer cells affecting PI3K/Akt pathway. +other 36793126 hsa-mir-146b Colorectal Neoplasms Moreover, we found that miR-146b-3p could be a key regulator for vascular endothelial cell dysfunction. +genetics_overexpression_suppress 36793115 hsa-mir-218 Osteoporosis 5p was downregulated in the OVX rat models, and silencing SOCS3 or overexpressing miR +genetics_overexpression_suppress 36793115 hsa-mir-218 Pars Planitis 5p was downregulated in the OVX rat models, and silencing SOCS3 or overexpressing miR +lncRNA target 36793108 hsa-mir-130a Carcinoma, Non-Small-Cell Lung The in vitro findings were reproduced in vivo, where ITF2357 inhibited the HDAC2/miR-130a-3p/Rad51 axis to reduce the resistance of mut-KRAS NSCLC to Pem. CONCLUSION: Taken together, HDAC inhibitor ITF2357 restores miR-130a-3p expression by inhibiting HDAC2, thereby repressing Rad51 and ultimately diminishing resistance of mut-KRAS NSCLC to Pem. +other 36792543 hsa-let-7a Breast Neoplasms Based on this, microRNA-21 and microRNA Let-7a in breast cancer cells were detected with the detection limits of 1.72 and 0.53 fM, respectively. +other 36792543 hsa-mir-21 Breast Neoplasms Based on this, microRNA-21 and microRNA Let-7a in breast cancer cells were detected with the detection limits of 1.72 and 0.53 fM, respectively. +transcription factor target 36791645 hsa-mir-181a-2 Colorectal Neoplasms In line with this, the miR-181a3p inhibitor transfection could increase tumorigenicity of NRF2-silenced colorectal cancer cells. +transcription factor target 36791628 hsa-mir-96 Liver Diseases Data from small RNA sequencing and bioinformatics analysis reveal that miR-396e, one of the most abundant miRNAs of GDE, is the key component to regulate PFKFB3 expression. Mechanistically, miR-396e-mediating PFKFB3 expression plays a crucial role in GDE inhibiting inflammatory response and enhancing lipid metabolism in hepatocytes via the macrophage-hepatocyte crosstalk. +other 36791156 hsa-mir-1262 mesangial proliferative glomerulonephritis 3p was decreased in the MsPGN patient group. +other 36791156 hsa-mir-548o mesangial proliferative glomerulonephritis 3p was decreased in the MsPGN patient group. +other 36791156 hsa-mir-205 mesangial proliferative glomerulonephritis 3p was decreased in the MsPGN patient group. +other 36791156 hsa-mir-125b-2 mesangial proliferative glomerulonephritis 3p was decreased in the MsPGN patient group. +other 36791156 hsa-let-7b mesangial proliferative glomerulonephritis 3p was decreased in the MsPGN patient group. +circRNA target 36790665 hsa-mir-497 Prostatic Neoplasms Our finding revealed that circ_0085494 downregulation might repress PCa tumor progression through in part regulating the miR +lncRNA target 36789845 hsa-mir-483 Myocardial Infarction 3p) to inhibit hypoxia-induced myocardial infarction. +genetics_overexpression_suppress 36789845 hsa-mir-483 Hypoxia Overexpression of miR +genetics_knock down_suppress 36789690 hsa-mir-96 Cardiomyopathies 5p knockdown using antagomir alleviates the aggravated cardiac fibrosis and exacerbated myocardial function caused by myocardial infarction surgery as shown by the echocardiography and Masson's staining analysis. +lncRNA target 36788697 hsa-mir-370 Inflammation MiR3p mimics inhibited XIST's effect on inflammation, viability, and apoptosis. +circulation_biomarker_diagnosis_up 36788514 hsa-mir-424 Pre-Eclampsia METHODS: Blood pressure and 24-h proteinuria of patients with preeclampsia (PE) were measured as well as the levels of miR +genetics_overexpression_promote 36787443 hsa-mir-378a Ventricular Premature Complexes TGF-beta1 treatment led to an upregulation of CTGF since early VC but not miR-378a-3p until mid-term VC, while miR-378a-3p overexpression suppressed CTGF expressions without altering TGF-beta1 levels. +circulation_biomarker_diagnosis_ns 36787323 hsa-mir-122 Aortic Aneurysm, Abdominal CONCLUSION: Plasma exosomes from AAA patients have significantly reduced levels of miRNA5p compared to controls. +genetics_knock down_promote 36787056 hsa-mir-545 Adenocarcinoma of Lung 3p inhibitor partially abolished the inhibition function of lncRNA PCAT6 knockdown on LUAD cells. +exosome 36786721 hsa-mir-183 Chemical and Drug Induced Liver Injury Moreover, in vivo experiments confirmed that miR-183 and exosomes from ADSCs could improve liver injury in rats and inhibit the MAPK and NF-kappaB pathways. All of these findings demonstrate that exosomes derived from ADSCs have a significant protective effect on hepatic I/R injury by regulating the miR-183/ALOX5 axis, which might provide a therapeutic strategy for liver injury. +other 36786410 hsa-mir-431 Carcinoma, Hepatocellular CircADSS could regulate HCC cell malignancy by miR5p/TOP2A axis. +lncRNA target 36786348 hsa-mir-450b Carcinoma, Hepatocellular Collectively, Silencing HCG18 inhibits GPX4 by binding to miR-450b-5p, promotes GPX4-inhibited ferroptosis, and averts sorafenib resistance in HCC. +genetics_GWAS 36786137 hsa-mir-146a Gout METHOD: A case-control study was performed in this report to examine the potential association between gout and the functional rs57095329 SNP of miR-146a in a Chinese population consisting of 448 primary gout patients (containing 76 tophi patients) and 418 healthy controls. +lncRNA target 36785792 hsa-mir-132 Myocardial Infarction CONCLUSIONS: The current study revealed the critical role of the MBNL1-AS1/miR3p/RAB14/CAMTA1 axis in MI, indicating MBNL1-AS1 as an innovative therapeutic target for MI. +other 36785666 hsa-mir-1321 Pancreatic Carcinoma Downregulating LINC01503 promoted the availability of miR-1321 in pancreatic cancer cells and thus repressed KLK4 expression. +other 36782343 hsa-mir-433 Osteosarcoma CONCLUSIONS: Overall, PCGEM1 mediated tumor growth and metastasis of OS by sponging miR3p and regulating OMA1, which might provide an innovative strategy for OS diagnosis or treatment. +lncRNA target 36782115 hsa-mir-130b Acute Lung Injury We have previously discovered that microRNA 130b-3p inhibits eCIRP mediated inflammation. +lncRNA target 36781680 hsa-mir-449a Fibrosis, Renal Therefore, miR-449a might act as a target in treating RIF. +genetics_overexpression_suppress 36781583 hsa-mir-18a Osteochondritis Dissecans ACVR2B served as a direct target of miR-18a-5p, and ACVR2B overexpression might abolish the inhibitory role of miR-18a-5p on OGD/R-treated HBMEC injury. +target gene 36781484 hsa-mir-1298 Polycystic Ovary Syndrome MicroRNA-1298-5p in granulosa cells facilitates cell autophagy in polycystic ovary syndrome by suppressing glutathione-disulfide reductase. +exosome 36781343 hsa-mir-142 Atrial Premature Complexes These data demonstrate that propofol inhibits osteogenic differentiation and mineralization of MSCs induced by PCa-derived exosomes by regulation of miR +other 36781308 hsa-mir-133a Osteoarthritis However, miR-133a-3p, miR-133b, and miR-206 were upregulated >2-fold in 62.5% or more of patients with late-stage osteoarthritis. +other 36781308 hsa-mir-206 Osteoarthritis However, miR-133a-3p, miR-133b, and miR-206 were upregulated >2-fold in 62.5% or more of patients with late-stage osteoarthritis. +other 36781308 hsa-mir-133b Osteoarthritis However, miR-133a-3p, miR-133b, and miR-206 were upregulated >2-fold in 62.5% or more of patients with late-stage osteoarthritis. +other 36781251 hsa-mir-132 Depression Herein, we developed a bidirectional-motivated bimodal isothermal strand displacement amplifier (BB-ISDA) for the ultrasensitive fluorescent and colorimetric detection of MDD-related miRNA-132. +transcription factor target 36781060 hsa-mir-149 Brain Ischemia 5p were further analyzed for their functional role during in vitro hypoxia by transfecting mitomiR mimics into cells and determining critical mitochondrial functions and cell viability. +transcription factor target 36781060 hsa-mir-204 Brain Ischemia 5p were further analyzed for their functional role during in vitro hypoxia by transfecting mitomiR mimics into cells and determining critical mitochondrial functions and cell viability. +genetics_GWAS 36780761 hsa-let-7 Ischemic Stroke Detecting let-7 promoter polymorphisms could raise awareness of the risk of IS, which directed individuals with risk alleles to have regular checks at an appropriate frequency to avoid developing the disease. +lncRNA target 36780323 hsa-mir-143 Myocardial Reperfusion Injury 3p's pathological role in the early stages of MI/RI, and inhibiting miR +other 36780058 hsa-mir-338 Carcinoma, Hepatocellular Circ_0124208 Promotes the Progression of Hepatocellular Carcinoma by Regulating the miR-338-3p/LAMC1 Axis. +lncRNA target 36779980 hsa-mir-34a Ovarian Neoplasms Diagnostics and Therapeutic Potential of miR-205 and miR-34a in Ovarian Cancer Epithelial ovarian cancer (EOC) treatment strategies mainly focused on surgery combined with chemotherapy. Targets of miRNA-205 and miRNA-34a were significantly downregulated, and upregulated, respectively, in EOC. +lncRNA target 36779980 hsa-mir-205 Ovarian Neoplasms Diagnostics and Therapeutic Potential of miR-205 and miR-34a in Ovarian Cancer Epithelial ovarian cancer (EOC) treatment strategies mainly focused on surgery combined with chemotherapy. Targets of miRNA-205 and miRNA-34a were significantly downregulated, and upregulated, respectively, in EOC. +genetics_knock down_promote 36778920 hsa-mir-1225 Carcinoma, Renal Cell 5p treatment further promoted the inhibitory ability of ARL4C knockdown. +lncRNA target 36777862 hsa-mir-34a Inflammatory Bowel Diseases CONCLUSIONS: Resveratrol attenuates IBD by promoting MUC2 synthesis via the ANRIL-miR-34a axis. +circulation_biomarker_diagnosis_down 36777859 hsa-mir-185 Pulmonary Disease, Chronic Obstructive 5p was down-regulated in serum-derived exosomes and lung tissues of COPD rats, indicating that these two miRNAs might be involved in the development of COPD and might serve as potential biomarkers for the diagnosis of COPD. +circulation_biomarker_diagnosis_down 36777859 hsa-mir-182 Pulmonary Disease, Chronic Obstructive 5p was down-regulated in serum-derived exosomes and lung tissues of COPD rats, indicating that these two miRNAs might be involved in the development of COPD and might serve as potential biomarkers for the diagnosis of COPD. +genetics_overexpression_promote 36777845 hsa-mir-145 Carcinoma, Renal Cell circ-AFF2 and circ-ASAP1 were highly expressed in RCC patient-derived tumor samples; their overexpression correlated with poor prognosis and low miR-145 levels. +genetics_overexpression_promote 36777826 hsa-mir-26a Cerebral Hemorrhage In contrast, overexpression of miR-26a alleviated the neurologic damage and promoted cerebral angiogenesis in ICH rats, but these could be attenuated by TUG1 overexpression. +lncRNA target 36777638 hsa-mir-92a Parkinson Disease Moreover, the microRNA-TFs-mRNA network revealed that the microRNA-92a family targets all four immune-related genes in PD pathogenesis. +lncRNA target 36777518 hsa-mir-141 Squamous Cell Carcinoma of Head and Neck PSMG3-AS1 increased OSCC cell proliferation and tumor growth and suppressed the inhibitory role of miR-141 in cell proliferation and tumor growth. +genetics_overexpression_suppress 36777504 hsa-mir-181a Uveal melanoma Furthermore, silencing GNAQ or AKT3 mimicked the anti-UM effects of miR-181a-5p, whereas overexpression of GNAQ or AKT3 rescued the anti-UM effects induced by miR-181a-5p. +other 36777002 hsa-mir-183 Thyroid Cancer, Papillary 5p expressions, as well as a significant decrease in FOXO1 and miR-30d-5p expressions, suggest that PTC cells may tend to preserve their autophagy capability. +other 36777002 hsa-mir-182 Thyroid Cancer, Papillary 5p expressions, as well as a significant decrease in FOXO1 and miR-30d-5p expressions, suggest that PTC cells may tend to preserve their autophagy capability. +lncRNA target 36776858 hsa-mir-222 Colorectal Neoplasms The in vivo results demonstrated that inhibiting miR +lncRNA target 36776858 hsa-mir-222 Inflammatory Bowel Diseases The in vivo results demonstrated that inhibiting miR +genetics_GWAS 36776296 hsa-mir-495 Thyroid Cancer, Papillary RESULTS: Overexpression of miR +lncRNA target 36776216 hsa-mir-6827 Ovarian Neoplasms 5p in OC cells, which may provide a potential target and biomarker for the diagnosis or prognosis of OC. +lncRNA target 36776011 hsa-mir-223 Hepatitis B Virus-Associated Glomerulonephritis Objective: To investigate the potential function and related mechanism of microRNA-223 (miRNA-223) in the podocyte pyroptosis of hepatitis B virus (HBV)-associated glomerulonephritis induced by HBV X protein (HBx). Conclusion: HBx may promote podocyte pyroptosis of HBV-GN via downregulating miRNA-223 targeting NLRP3 inflammasome, suggesting that miRNA-223 is expected to be a potential target for the treatment of HBV-GN. +exosome 36775818 hsa-mir-146a Diabetes Mellitus Here, the engineered exosomes modified for efficiently loading miR146a and attaching to silk fibroin patch (SFP) were demonstrated to promote diabetic wound healing. +circRNA target 36775571 hsa-mir-340 Colorectal Neoplasms Our data indicated an oncogenic role of circN4BP2L2 in CRC via regulation of the miR5p/CXCR4 axis, which may be a promising biomarker and target for CRC treatment. +genetics_overexpression_suppress 36775560 hsa-mir-150 Colonic Neoplasms 3p and/or SLCO4A1 were overexpressed or depleted in colon cancer cells to detect their effects on migration, invasion, sphere formation, apoptosis and tumorigenesis abilities of colon cancer stem CD133(+)CD44(+) cells using both in vitro and in vivo assays. +lncRNA target 36775555 hsa-mir-135a Hypoxia-Ischemia, Brain M2 microglia-derived EVs delivered miR-135a-5p into neuronal cells to inhibit TXNIP expression, which further inhibited the activation of NLRP3 inflammasome, thereby reducing neuronal autophagy and ischemic brain injury. Mechanistically, M2 microglia-derived EVs deliver miR-135a-5p into neuronal cells to inhibit TXNIP expression, which further inhibits the activation of NLRP3 inflammasomes, thereby reducing neuronal autophagy and ischemic brain injury. +exosome 36775554 hsa-mir-21 Rett Syndrome In the present study, we sought to determine whether that exosomal miR5p from USCs could promote early neural formation in a model of RTT. +other 36775545 hsa-mir-140 Alcoholism Prostacyclin synthase (PTGIS) levels are decreased by elevated miR3p.1 expression in chronic alcoholic liver disease. +other 36775545 hsa-mir-140 Liver Injury Prostacyclin synthase (PTGIS) levels are decreased by elevated miR3p.1 expression in chronic alcoholic liver disease. +lncRNA target 36775540 hsa-mir-143 Carcinoma, Non-Small-Cell Lung 3p inhibitor rescued the inhibitory effect of sh-UCC on the proliferation of NSCLC cells. +lncRNA target 36775537 hsa-mir-150 Sepsis 5p and c-Fos, regulate sepsis-induced myocardial injury via the TXNIP pathway. +lncRNA target 36775537 hsa-mir-150 Cardiomyopathies 5p and c-Fos, regulate sepsis-induced myocardial injury via the TXNIP pathway. +lncRNA target 36775498 hsa-mir-26b Leukemia, Myeloid, Acute This study reveals that upregulation of lncRNA small nucleolar RNA host gene 5 (SNHG5), mediated by Yin Yang 1 (YY1), activates connective tissue growth factor (CTGF)/vascular endothelial growth factor (VEGFA) axis via targeting miR-26b to regulate angiogenesis of acute myelogenous leukemia (AML), providing new insights into mechanisms of AML. +exosome 36775496 hsa-mir-199a Thrombocytopenia Supplementation of extracellular vesicles (EVs) derived from miR-199a-5p-modified ADSCs markedly repress Th17 differentiation by transferring miR-199a-5p to CD4(+)T cells, thus ameliorating experimental ITP. +transcription factor target 36775482 hsa-mir-130b Adenocarcinoma of Lung Hence, targeting miR-130b may serve as a potential therapeutic strategy for lung cancer. Hence, miR-130b is a potential therapeutic target for lung cancer. +target gene 36775481 hsa-mir-184 Idiopathic Pulmonary Fibrosis miR-184 targets TP63 to block idiopathic pulmonary fibrosis by inhibiting proliferation and epithelial-mesenchymal transition of airway epithelial cells. +lncRNA target 36775475 hsa-mir-22 Hypogonadism This study reveals that lncRNA MIR22HG upregulates NDRG2 expression by targeting miR-125a-5p, thus promoting Leydig cell apoptosis in late-onset hypogonadism. +lncRNA target 36775475 hsa-mir-125a Hypogonadism This study reveals that lncRNA MIR22HG upregulates NDRG2 expression by targeting miR-125a-5p, thus promoting Leydig cell apoptosis in late-onset hypogonadism. +lncRNA target 36775469 hsa-mir-214 Atrial Fibrillation XIST then suppresses NLRP3 inflammasome activation and myocardial pyroptosis by reducing miR +circulation_biomarker_prognosis_ns 36775455 hsa-mir-221 Heart Failure Furthermore, serum miR +genetics_overexpression_promote 36775453 hsa-mir-96 Carcinoma, Hepatocellular 5p transfection promoted proliferation, migration and invasion of SMMC-7721 and MHCC-97H hepatoma cells; whereas the function of oncogenic microRNA-96 was significantly inhibited in GPM6A-overexpressed hepatoma cells. +genetics_overexpression_promote 36775444 hsa-mir-193a Carcinoma, Non-Small-Cell Lung We also found that restoration of miR-193a-5p rescued NSCLC cell biological functions affected by overexpression of lncRNA DLGAP1-AS1. +lncRNA target 36775436 hsa-mir-27a Lung Injury Altogether, our study revealed that NEAT1 plays a promoting role in the progression of ARDS via the NEAT1/miR-27a/PTEN regulatory network, providing new insight into the pathologic mechanism behind ARDS. In the present study, the authors reveal that NEAT1 plays a role in the inflammation and cell cycle progression of ARDS via the NEAT1/miR-27a/PTEN regulatory network, providing new insight into the pathologic mechanism behind ARDS. +lncRNA target 36775429 hsa-mir-20a Leukemia, Myeloid, Acute In addition, HOTAIR upregulated WT1 expression by targeting miR-20a-5p, and inhibition of miR-20a-5p reversed the regulation of Adriamycin resistance by curcumin in AML cells. +other 36775425 hsa-mir-513a Lupus Nephritis Our findings indicated that circRTN4 exacerbates mesangial cell dysfunction by activating the miR-513a-5p/FN axis in lupus nephritis. +circRNA target 36775423 hsa-mir-20a Acute Lung Injury Our findings suggested that circHECTD1 inhibits the apoptosis of AECs through miR-320a/PIK3CA and miR-136/Sirt1 pathways in LPS-induced ALI. +circRNA target 36775423 hsa-mir-136 Acute Lung Injury Our findings suggested that circHECTD1 inhibits the apoptosis of AECs through miR-320a/PIK3CA and miR-136/Sirt1 pathways in LPS-induced ALI. +genetics_overexpression_promote 36775421 hsa-mir-148a Nasopharyngeal Carcinoma Silencing of SRGN and CREB1, as well as miR-148a-5p overexpression, repressed NPC tumor progression in vitro and in vivo. +exosome 36775383 hsa-mir-1246 Glioma and miR-10b-5p-rich exosomes that are delivered to normoxic glioma cells to promote their migration and invasion; treatment targeting miR-1246 and miR-10b-5p may impair the motility of gliomas, providing a novel direction for the development of antitumor therapy. +exosome 36775383 hsa-mir-10b Glioma and miR-10b-5p-rich exosomes that are delivered to normoxic glioma cells to promote their migration and invasion; treatment targeting miR-1246 and miR-10b-5p may impair the motility of gliomas, providing a novel direction for the development of antitumor therapy. +genetics_GWAS 36775382 hsa-mir-138 Cartilage Diseases This study aimed to examine the molecular mechanism of enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2)/microRNA-138 (miR-138)/syndecan 1 (SDC1) and its epigenetic regulation in cartilage degeneration in OA. +genetics_GWAS 36775382 hsa-mir-138 Osteoarthritis This study aimed to examine the molecular mechanism of enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2)/microRNA-138 (miR-138)/syndecan 1 (SDC1) and its epigenetic regulation in cartilage degeneration in OA. +genetics_overexpression_promote 36775374 hsa-mir-34b Asthma Notably, EZH2 and BTG2 were significantly overexpressed, while FOXO3 and miR-34b were obviously underexpressed in asthma. +lncRNA target 36775364 hsa-mir-96 Osteoarthritis 5p expression, which results in targeting HIF-2alpha 3'-UTR sequences and inhibiting HIF-2alpha in murine cartilage tissue and chondrocytes. +target gene 36775360 hsa-mir-432 Osteosarcoma MicroRNA-432-5p regulates sprouting and intussusceptive angiogenesis in osteosarcoma microenvironment by targeting PDGFB. +circulation_biomarker_diagnosis_up 36775328 hsa-mir-143 Myocardial Infarction CONCLUSIONS: An increase in plasma miR-143 concentrations in the acute phase may be a biomarker predicting recovery of LV function in the chronic phase in AMI patients. +other 36775115 hsa-mir-663a Lung Neoplasms GSE and MTE additively upregulated miR-663a and FHIT in lung cancer cell lines; transfection of antisense-miR-663a significantly abrogated the anti-proliferative effects of GSE/MTE, upregulation of FHIT mRNA and protein. LP and siliphos also additively increased miR-663a and FHIT protein in lung tumor xenografts. +other 36774884 hsa-mir-296 Carcinoma, Non-Small-Cell Lung Circular RNA circFBXO7 attenuates non-small cell lung cancer tumorigenesis by sponging miR-296-3p to facilitate KLF15-mediated transcriptional activation of CDKN1A. +lncRNA target 36773565 hsa-mir-144 Diabetes Mellitus, Type 2 3p dysregulation. +other 36772911 hsa-mir-494 Dmd-Associated Dilated Cardiomyopathy The results showed that the expression level of miR-494 was higher in the myocardial tissue of DCM rats and the myocardial cells of H9c2 treated with HG. +circulation_biomarker_diagnosis_down 36771341 hsa-mir-122 Alzheimer Disease A final binary logistic regression analysis showed that alpha-tocopherol serum levels were associated with a higher AD probability and partially mediated by miR-122. +circRNA target 36770940 hsa-mir-1268b Atherosclerosis In conclusion, circSCRG1 might serve as a new target regulating angiogenesis in atherosclerosis via the circSCRG1/miR-1268b/NR4A1 axis and TMP-PF could regulate the circSCRG1/miR-1268b/NR4A1 axis to inhibit angiogenesis in atherosclerosis in vitro, indicating a novel angiogenesis signalling circSCRG1/miR-1268b/NR4A1 pathway in atherosclerosis and the regulatory effects of TMP-PF, which might provide a new pharmaceutical strategy to combat atherosclerotic plaque instability. +target gene 36769824 hsa-mir-197 Osteosarcoma miR-197-3p Promotes Osteosarcoma Stemness and Chemoresistance by Inhibiting SPOPL. +circulation_biomarker_diagnosis_up 36769594 hsa-mir-1 Aortic Aneurysm, Abdominal 3p expression (overall and for age < 65 years, aneurysm-related death or cardiac death subgroup) when compared to alive patients; further Cox regression yielded an independent relationship of preoperative low serum miR +other 36769379 hsa-mir-145 Premature Ovarian Aging Expression levels of well-known (Amh, Gdf9, and Inhibins) and novel (miR143/145 and Gas5) biomarkers of POA were assessed. +other 36769379 hsa-mir-143 Premature Ovarian Aging Expression levels of well-known (Amh, Gdf9, and Inhibins) and novel (miR143/145 and Gas5) biomarkers of POA were assessed. +lncRNA target 36769373 hsa-mir-340 Nasopharyngeal Carcinoma 3p/FKBP5 network may be instrumental in regulating NPC radioresistance by enhancing autophagy, which provides potential new therapeutic targets for NPC. +other 36769354 hsa-mir-21 Rhegmatogenous Retinal Detachment, Autosomal Dominant We found the existence of a positive association between the expression of miR-21 (p = 0.017, r = 0.515) and miR-34 (p = 0.030, r = 0.624) and the duration of symptoms related to retinal detachment. +other 36769354 hsa-mir-146a Rhegmatogenous Retinal Detachment, Autosomal Dominant Moreover, the expression of miR-146a tended to decrease in patients who developed PVR. +other 36769177 hsa-mir-155 Breast Neoplasms We found that the system is capable of specific detection of miR-155, a microRNA implicated in the carcinogenesis of human breast cancer. +circulation_biomarker_diagnosis_up 36769143 hsa-mir-434 Brain Injuries, Traumatic These included 7 brain-enriched plasma miRNAs (miR +circulation_biomarker_diagnosis_up 36769143 hsa-mir-9a Brain Injuries, Traumatic These included 7 brain-enriched plasma miRNAs (miR +lncRNA target 36769104 hsa-mir-212 Hypoxia Then, we predicted the upstream miRNAs of MCM2 through TargetScan and miRanDa and selected miR +lncRNA target 36769104 hsa-mir-212 Cerebrovascular Disorders Taken together, these results suggest that the miR3p/MCM2 axis plays an important role in BMECs under hypoxia and provide a potential target for the treatment of BBB disorder-related cerebrovascular disease. +lncRNA target 36769104 hsa-mir-212 Opitz GBBB Syndrome, X-Linked Taken together, these results suggest that the miR3p/MCM2 axis plays an important role in BMECs under hypoxia and provide a potential target for the treatment of BBB disorder-related cerebrovascular disease. +other 36768818 hsa-mir-20b Testicular Germ Cell Tumor 3p, miR-20b-5p and miR-378a-3p represent a new panel of biomarkers for better prediction of chemoresistance and more aggressive phenotypes potentially underlying metastatic spread in non-seminomatous TGCTs. +other 36768818 hsa-mir-1 Testicular Germ Cell Tumor 3p, miR-20b-5p and miR-378a-3p represent a new panel of biomarkers for better prediction of chemoresistance and more aggressive phenotypes potentially underlying metastatic spread in non-seminomatous TGCTs. +other 36768818 hsa-mir-517 Testicular Germ Cell Tumor 3p, miR-20b-5p and miR-378a-3p represent a new panel of biomarkers for better prediction of chemoresistance and more aggressive phenotypes potentially underlying metastatic spread in non-seminomatous TGCTs. +other 36768818 hsa-mir-375 Testicular Germ Cell Tumor 3p, miR-20b-5p and miR-378a-3p represent a new panel of biomarkers for better prediction of chemoresistance and more aggressive phenotypes potentially underlying metastatic spread in non-seminomatous TGCTs. +other 36768818 hsa-mir-218 Testicular Germ Cell Tumor 3p, miR-20b-5p and miR-378a-3p represent a new panel of biomarkers for better prediction of chemoresistance and more aggressive phenotypes potentially underlying metastatic spread in non-seminomatous TGCTs. +other 36768818 hsa-mir-378a Testicular Germ Cell Tumor 3p, miR-20b-5p and miR-378a-3p represent a new panel of biomarkers for better prediction of chemoresistance and more aggressive phenotypes potentially underlying metastatic spread in non-seminomatous TGCTs. +transcription factor target 36768805 hsa-mir-92a Cardiac Microvascular Inflammation Altogether, our data strongly qualify miR-92a as a potential therapeutic target for diabetes-associated cardiovascular disease. +lncRNA target 36768805 hsa-mir-92a Diabetes Mellitus We previously characterized the cardiac microvascular inflammatory phenotype in diabetic patients and highlighted micro-RNA 92a (miR-92a) as a driver of endothelial dysfunction. Altogether, our data strongly qualify miR-92a as a potential therapeutic target for diabetes-associated cardiovascular disease. +lncRNA target 36768775 hsa-mir-21 Endometriosis The Expression of TGF-1, SMAD3, ILK and miRNA-21 in the Ectopic and Eutopic The molecular pathogenesis of endometriosis has been associated with pathological alterations of protein expression via disturbances in homeostatic genes, miRNA expression profiles, and signaling pathways that play an essential role in the epithelial-mesenchymal transition (EMT) process. Compared to the endometrium of healthy participants, miR-21 expression levels did not change in the eutopic endometrium of women with endometriosis, but the RQ was higher in their endometrial implants. +other 36768614 hsa-mir-124 Diabetic Retinopathy In rat DR, miR-124 prevents vasoregression and glial activation, improves neuroretinal function, and modulates microglial activation and inflammatory responses. +other 36768376 hsa-mir-16 Depression Our findings suggest that the antidepressant effects of CBD in a rat model for depression are associated with alterations in miR-16 and miR-135 in the vmPFC and are mediated by the 5HT1a receptor. +other 36768376 hsa-mir-135 Depression Our findings suggest that the antidepressant effects of CBD in a rat model for depression are associated with alterations in miR-16 and miR-135 in the vmPFC and are mediated by the 5HT1a receptor. +other 36768376 hsa-mir-135a Depression Our findings suggest that the antidepressant effects of CBD in a rat model for depression are associated with alterations in miR-16 and miR-135 in the vmPFC and are mediated by the 5HT1a receptor. +lncRNA target 36768146 hsa-mir-182 Prostatic Neoplasms In summary, this is the first study to report that miR-182 over-expression in prostate cancer may contribute to EMT by targeting MITF expression. +circulation_biomarker_diagnosis_ns 36766808 hsa-mir-155 Acquired Immunodeficiency Syndrome We propose that the activation of peripheral blood mononuclear cells (PBMCs) leads to an increased miR-155 expression and production of miR +lncRNA target 36766731 hsa-mir-193a Breast Neoplasms In conclusion, miR193a-3p can potentially modify the tumor microenvironment by altering pro-growth BC secretome and inhibiting LEC growth, and may represent a therapeutic molecule to target breast tumors/cancer. +lncRNA target 36766731 hsa-mir-193a Bulimia Nervosa We have recently shown that miR193a-3p, a tumor suppressor miRNA, inhibits MCF-7 BC cell-driven growth of VECs via direct antimitogenic actions and alters MCF-7 secretome. +other 36766397 hsa-mir-411b Hidradenitis Suppurativa 3p, were downregulated (p < 0.05) as compared to the LSR and MSR groups. +other 36766397 hsa-mir-1193 Hidradenitis Suppurativa 3p, were downregulated (p < 0.05) as compared to the LSR and MSR groups. +other 36766397 hsa-mir-485 Hidradenitis Suppurativa 3p, were downregulated (p < 0.05) as compared to the LSR and MSR groups. +other 36766397 hsa-mir-381 Hidradenitis Suppurativa 3p, were downregulated (p < 0.05) as compared to the LSR and MSR groups. +other 36766397 hsa-mir-3957 Hidradenitis Suppurativa 3p, were downregulated (p < 0.05) as compared to the LSR and MSR groups. +other 36766397 hsa-mir-376b Hidradenitis Suppurativa 3p, were downregulated (p < 0.05) as compared to the LSR and MSR groups. +other 36766397 hsa-mir-376c Hidradenitis Suppurativa 3p, were downregulated (p < 0.05) as compared to the LSR and MSR groups. +other 36765584 hsa-mir-21 Colorectal Neoplasms Tumour Necrosis Factor-Alpha (TNF-α)-Induced Metastatic Phenotype in Colorectal Cancer Epithelial Cells: Mechanistic Support for the Role of MicroRNA-21. +other 36765487 hsa-mir-125 Lymphoma, Large B-Cell, Diffuse CONCLUSION: The expression of miR-195 decreases and the expression of miR-125 and calreticulin increase in patients with DLBCL. +other 36765487 hsa-mir-195 Lymphoma, Large B-Cell, Diffuse CONCLUSION: The expression of miR-195 decreases and the expression of miR-125 and calreticulin increase in patients with DLBCL. +other 36765483 hsa-mir-424 Lymphoma, Large B-Cell, Diffuse 5p enhances the drug resistance of DLBCL cells by regulating the PD-1/PD-L1 signaling pathway. +lncRNA target 36765482 hsa-mir-20a Lymphoma OBJECTIVE: To investigate the effects of lncRNA HOTAIR on the proliferation, invasion and migration of lymphoma cells through target gene miR-20a-5p and its molecular mechanism. CONCLUSION: HOTAIR affects the proliferation, invasion and migration of lymphoma cells by targeting miR-20a-5p, and its mechanism may be related to the activation of JAK/STAT3 signaling pathway. +transcription factor target 36765480 hsa-mir-144 Leukemia, Myelogenous, Chronic, BCR-ABL Positive 3p can inhibit the proliferation and promote apoptosis of K562 cells, affect the cell cycle, and block K562 cells in S phase, which indicates that miR +lncRNA target 36765401 hsa-mir-148 Stomach Neoplasms CONCLUSIONS: This study demonstrates that the miR-148/152 family members may prevent gastric cancer stem cell-like properties by targeting ITGA5, which can serve as an appealing target for gastric cancer treatment. +other 36764873 hsa-mir-1178 Breast Neoplasms 3p and thus upregulating TMED3. +other 36764602 hsa-mir-135a Spinal Cord Injuries In summary, the miR-135a-5p/SP1 axis regulates astrocyte proliferation and migration after SCI. +exosome 36764461 hsa-mir-203a Diabetes Mellitus CONCLUSIONS: Our results demonstrated that the abundant miR-203a-3p present in EpiSC-EXOs can promote M2 macrophage polarization by downregulating SOCS3 and suggested that diabetic wounds can obtain better healing effects through this mechanism. +transcription factor target 36764280 hsa-mir-155 Rhinitis, Allergic Therefore, our results suggest that blocking the Notch pathway may alleviate miRmediated inflammation via the regulation of immune homeostasis in AR. +transcription factor target 36764278 hsa-mir-223 Acute Liver Injury CONCLUSIONS: SPC alleviates acute liver injury through up-regulating the expression of miR3p. +circRNA target 36764273 hsa-mir-483 Osteoporosis In conclusion, hsa_circ_0006859 is involved in PMOP by targeting miR-642b-5p/EFNA2 and miR3p/DOCK3 axes to maintain the Wnt-signaling pathway, which may be a novel possible therapeutic targets and biomarkers for PMOP. +circRNA target 36764273 hsa-mir-642b Osteoporosis In conclusion, hsa_circ_0006859 is involved in PMOP by targeting miR-642b-5p/EFNA2 and miR3p/DOCK3 axes to maintain the Wnt-signaling pathway, which may be a novel possible therapeutic targets and biomarkers for PMOP. +transcription factor target 36764271 hsa-mir-34b Myocardial Reperfusion Injury MiR-34b-3p and Jagged1 levels were increased and decreased in myocardial I/R injury model, respectively, while Dex reversed this effect. Dex relieved the myocardial I/R injury of rats via inhibiting miR-34b-3p and further activating Notch signaling pathway. +lncRNA target 36764156 hsa-mir-100 Stomach Neoplasms 3p promoted cell growth, invasion, and migration but inhibited apoptosis in GC cells. +lncRNA target 36764156 hsa-mir-145 Stomach Neoplasms 3p promoted cell growth, invasion, and migration but inhibited apoptosis in GC cells. +lncRNA target 36763225 hsa-mir-199a Lupus Erythematosus, Systemic * miR-199a-3p in CD4+ T cells plays a novel role in the pathogenesis of SLE and serves as a potential target for SLE. +lncRNA target 36763221 hsa-mir-769 Colorectal Neoplasms CONCLUSION: Circ_0084188 upregulated the expression of KIF20A to promote the tumorigenesis of CRC through miR +lncRNA target 36762306 hsa-mir-493 Stomach Neoplasms Furthermore, research into the underlying mechanisms of propofol's suppressive effects in GC cell proved that propofol therapy improved the degrees of expression of the potential tumor suppressor miR +lncRNA target 36762036 hsa-mir-505 Glioblastoma All in all, we concluded that the highly expressed KTN1-AS1 in GBM played oncogenic roles to facilitate GBM progression by targeting miR-505. +lncRNA target 36762032 hsa-mir-491 Pancreatic Carcinoma Collectively, the findings from our study found a new potential strategy for gemcitabine resistance in PCa by illustrating the mechanistic insights of oncogenic ADSC-derived EVs-loaded NEAT1 via regulating the miR +circulation_biomarker_diagnosis_ns 36761245 hsa-mir-506 Osteoporosis, Postmenopausal CONCLUSION: Our work suggested that circulating miR +circulation_biomarker_diagnosis_ns 36761245 hsa-mir-340 Osteoporosis, Postmenopausal CONCLUSION: Our work suggested that circulating miR +other 36761165 hsa-mir-1321 Autism Spectrum Disorder Two miRNAs (miR3p and miR-1321) and 23 agents were linked with ASD. +other 36761165 hsa-mir-342 Autism Spectrum Disorder Two miRNAs (miR3p and miR-1321) and 23 agents were linked with ASD. +other 36760866 hsa-mir-26a Carcinoma, Renal Cell After performing a comprehensive analysis of the regulatory mechanisms of SLC7A11 expression, the results depicted a potential noncoding (ncRNA)-messenger RNA (mRNA) axis, incorporating SNHG6-miR-26a-5p-SLC7A11 networks in KICH, CASC19/CYTOR/LINC00997-miR-27b-3pSLC7A11 networks in KIRC, and CASC19/CYTOR/PVT1-miR27b-3p-SLC7A11 networks in KIRP as partially responsible for the functions of SLC7A11 in RCC. +other 36760866 hsa-mir-27b Carcinoma, Renal Cell After performing a comprehensive analysis of the regulatory mechanisms of SLC7A11 expression, the results depicted a potential noncoding (ncRNA)-messenger RNA (mRNA) axis, incorporating SNHG6-miR-26a-5p-SLC7A11 networks in KICH, CASC19/CYTOR/LINC00997-miR-27b-3pSLC7A11 networks in KIRC, and CASC19/CYTOR/PVT1-miR27b-3p-SLC7A11 networks in KIRP as partially responsible for the functions of SLC7A11 in RCC. +lncRNA target 36760811 hsa-mir-485 Osteoporosis DISCUSSION: In conclusion, MALAT1 promoted osteogenic differentiation and inhibited cell apoptosis through the miR5p/WNT7B axis, which suggested that MALAT1 is a potential target to alleviate osteoporosis. +other 36760722 hsa-mir-16 Stomach Neoplasms 5p/HMGA1 axis to regulate the Tax resistance of GC cells. +other 36760720 hsa-mir-16 Stomach Neoplasms PVT1/miR-16/CCND1 axis regulates gastric cancer progression. +lncRNA target 36760719 hsa-mir-153 Carcinoma, Non-Small-Cell Lung 3p sponge and regulated ITGB1 expression via adsorbing miR +lncRNA target 36760373 hsa-mir-135a Hepatitis B, Chronic CONCLUSIONS: HBV promoted the proliferation and invasion, and inhibited the apoptosis of HCC cells by regulating the miR-135a/HOXA10 pathway. +lncRNA target 36760373 hsa-mir-135a Carcinoma, Hepatocellular CONCLUSIONS: HBV promoted the proliferation and invasion, and inhibited the apoptosis of HCC cells by regulating the miR-135a/HOXA10 pathway. +genetics_overexpression_promote 36760249 hsa-mir-495 Bronchopulmonary Dysplasia CONCLUSIONS: The aberrant overexpression of miR-495 may contribute to the development of BPD by targeting NEDD4L-ENaC pathway, implying an imbalance in lung fluid clearance. +other 36760244 hsa-mir-34c Ovarian Neoplasms We determined that LINC00665 is the most potential lncRNA upstream of ovarian cancer miRNA (hsa-miR-34c-5p)-P2RY14. Intervention of P2RY14 can affect the prognosis of ovarian cancer by affecting LINC00665-miR-34c-5p-P2RY14 axis. +other 36760243 hsa-mir-7 Carcinoma, Hepatocellular miR-7/BCL2L1/P53 signaling axis regulating the progression of hepatocellular carcinoma. +other 36759837 hsa-mir-375 Non-alcoholic Fatty Liver Disease Ginsenoside Rg1 attenuates the NASH phenotype by regulating the miR-375-3p/ATG2B/PTEN-AKT axis to mediate autophagy and pyroptosis. +other 36758875 hsa-mir-204 Depression 3p, hsa-miR-146a-5p, and hsa-miR-26a-5p). +other 36758875 hsa-mir-146a Depression 3p, hsa-miR-146a-5p, and hsa-miR-26a-5p). +other 36758875 hsa-mir-1 Depression 3p, hsa-miR-146a-5p, and hsa-miR-26a-5p). +other 36758875 hsa-mir-16 Depression 3p, hsa-miR-146a-5p, and hsa-miR-26a-5p). +other 36758875 hsa-mir-124 Depression 3p, hsa-miR-146a-5p, and hsa-miR-26a-5p). +other 36758875 hsa-mir-206 Depression 3p, hsa-miR-146a-5p, and hsa-miR-26a-5p). +other 36758875 hsa-mir-132 Depression 3p, hsa-miR-146a-5p, and hsa-miR-26a-5p). +other 36758875 hsa-mir-26a Depression 3p, hsa-miR-146a-5p, and hsa-miR-26a-5p). +epigenetics 36758856 hsa-mir-29b Pulmonary Disease, Chronic Obstructive Collectively, these findings indicate that the miR-29b level in COPD controls Klotho methylation via DNMT3, which maybe a promising target for the treatment of COPD. +circRNA target 36758707 hsa-mir-139 Liver Cirrhosis Mechanistically, circASPH directly targeted miR +lncRNA target 36758592 hsa-mir-124 Calcinosis RESULTS: Compared with the blank group and no-load group, the A450 value at 24, 48, 72 h detected by CCK-8 experiment, A450 value of ALP activity, the area composition ratio of calcified nodules, and expression of HEY1, HEY2, and CCND1 in the miR-124 inhibitor group were increased (P<0.05). Compared with miR-124 inhibitor group, the A450 value at 24, 48, 72 h detected by CCK-8 experiment, A450 value of ALP activity, the area composition ratio of calcified nodules, and the expression of HEY1, HEY2, and CCND1 in the miR-124 inhibitor combined with DAPT group were significantly decreased(P<0.05). +transcription factor target 36758470 hsa-mir-206 Abortion, Spontaneous Moreover, we found the higher expression of miR-206 and miRNA-30a (p = 0.0038, 0.0123), but the lower expression of miRNA-18a (p = 0.0101) in RPL. In conclusion, we observed the dysregulation of molecules that are involved in ATP catabolism and hypoxia, including CD39, CD73, and HIF-1a which is related to miR-18a, miR-30a, and miR-206 change in RPL women. +transcription factor target 36758470 hsa-mir-18a Abortion, Spontaneous Moreover, we found the higher expression of miR-206 and miRNA-30a (p = 0.0038, 0.0123), but the lower expression of miRNA-18a (p = 0.0101) in RPL. In conclusion, we observed the dysregulation of molecules that are involved in ATP catabolism and hypoxia, including CD39, CD73, and HIF-1a which is related to miR-18a, miR-30a, and miR-206 change in RPL women. +circulation_biomarker_diagnosis_ns 36757626 hsa-mir-488 Esophageal Squamous Cell Carcinoma circ_0024108 participated in the progress of ESCC through the miR-488-3p/USP14 axis. Circ_0024108 was differentially expressed in serum exosomes. Circ_0024108 might be a potential biomarker for the diagnosis of ESCC. +other 36757530 hsa-mir-34a Non-alcoholic Fatty Liver Disease Also, miRNA-34a was positively correlated with metabolic disorders associated with NAFLD such as hypertension and diabetes. +circulation_biomarker_diagnosis_up 36757530 hsa-mir-192 Non-alcoholic Fatty Liver Disease Thus, larger cohorts are necessitated to certify the utility of serum MiRNA-34a and MiRNA-192 in monitoring the deterioration of NAFLD. +genetics_overexpression_suppress 36757298 hsa-mir-23b Uterine Diseases miR-23b-3p overexpression in infertile endometrial organoid-derived epithelial cells did not improve adhesion. +genetics_overexpression_promote 36756790 hsa-mir-21 Carcinoma, Renal Cell Moreover, upregulation of PTEN, which is a target of miR-21, was observed in ccRCC cells with overexpression of GABPB1-IT1. +exosome 36756722 hsa-mir-128 Brain Ischemia 3p promotes OPC differentiation into OLs by suppressing BMP signaling, indicating that NSC-derived exosomal miR +genetics_knock down_promote 36756719 hsa-mir-542 Glioma A battery of function experiments, including the CCK-8 viability test, colony formation assay, scratch migration assay, and Transwell invasion assay, was executed to address the responses of glioma cells to MTE treatment and gain or loss of function of lncMEG3, miR +genetics_knock down_promote 36756106 hsa-mir-19b Leukemia, Myeloid, Acute Conclusion MiR-19b, miR-17, and miR-25 are aberrantly expressed in AML patients' peripheral blood leukocytes, which may play a role in the development of acute GvHD following hematopoietic stem cell transplantation. +other 36756106 hsa-mir-17 Leukemia, Myeloid, Acute We have investigated whether changes in the level of micro-ribonucleic acid (miR)-19b, miR-17, and miR-25, Wilms' tumor (WT1), and CCAAT enhancer-binding protein alpha (CEBPA) genes expression affect disease prognosis and clinical outcome in AML patients. +genetics_knock down_promote 36756106 hsa-mir-25 Leukemia, Myeloid, Acute Conclusion MiR-19b, miR-17, and miR-25 are aberrantly expressed in AML patients' peripheral blood leukocytes, which may play a role in the development of acute GvHD following hematopoietic stem cell transplantation. +target gene 36755807 hsa-mir-502 Colorectal Neoplasms FOXO1-Induced miR-502-3p Suppresses Colorectal Cancer Cell Growth through Targeting CDK6. +circulation_biomarker_prognosis_up 36755690 hsa-mir-135b Carcinoma, Hepatocellular RESULTS: Upregulation of miR-135b-5p was detected in patients with HCC with high serum AFP levels (AFP > 400 ng/ml). +genetics_GWAS 36755123 hsa-mir-4510 Breast Neoplasms Two SNPs outside the miR-4510 binding site occurred, and Guanine (G) in both BC and NAT was changed into Thymine (T), as compared to the reference sequence (RefSeq). +lncRNA target 36754869 hsa-mir-20b Cicatrix, Hypertrophic Small nucleolar RNA host gene 1 (SNHG1) aced as a ceRNA to upregulate CTNNB1 expression via sponging miR-320b in HSFB. +genetics_knock down_promote 36754085 hsa-mir-1299 Triple Negative Breast Neoplasms MiR-1299 interacted with the 3' untranslated region (3' UTR) of YY1, and YY1 overexpression partly reversed the effects of miR-1299 overexpression on BC progression. +transcription factor target 36753931 hsa-mir-1296 Placenta Accreta Additionally, the dual-luciferase assay confirmed AGGF1 as a target gene of miR5p in placental tissues of PAS. +exosome 36753414 hsa-mir-218 Anxiety Disorders As BDNF and EV-miRNAs miR-218 and miR-132 were previously implicated in neuropsychiatric disorders such as anxiety and depression, our results contribute to a better understanding of disorders characterized by aberrant neural circuit connectivity. +exosome 36753414 hsa-mir-132 Mental Disorders As BDNF and EV-miRNAs miR-218 and miR-132 were previously implicated in neuropsychiatric disorders such as anxiety and depression, our results contribute to a better understanding of disorders characterized by aberrant neural circuit connectivity. +exosome 36753414 hsa-mir-132 Anxiety Disorders As BDNF and EV-miRNAs miR-218 and miR-132 were previously implicated in neuropsychiatric disorders such as anxiety and depression, our results contribute to a better understanding of disorders characterized by aberrant neural circuit connectivity. +exosome 36753414 hsa-mir-132 Neurotic Disorders As BDNF and EV-miRNAs miR-218 and miR-132 were previously implicated in neuropsychiatric disorders such as anxiety and depression, our results contribute to a better understanding of disorders characterized by aberrant neural circuit connectivity. +exosome 36753414 hsa-mir-218 Mental Disorders As BDNF and EV-miRNAs miR-218 and miR-132 were previously implicated in neuropsychiatric disorders such as anxiety and depression, our results contribute to a better understanding of disorders characterized by aberrant neural circuit connectivity. +exosome 36753414 hsa-mir-218 Neurotic Disorders As BDNF and EV-miRNAs miR-218 and miR-132 were previously implicated in neuropsychiatric disorders such as anxiety and depression, our results contribute to a better understanding of disorders characterized by aberrant neural circuit connectivity. +transcription factor target 36753399 hsa-mir-124 Mitochondrial Diseases These results showed that under high-glucose and high-lipid conditions, the down-regulation of miR3p induces FOXQ1 in renal tubular epithelial cells, which in turn suppresses Sirt4 and leads to mitochondrial dysfunction, promoting the development of DKD. +transcription factor target 36753399 hsa-mir-124 dystonia 5 3p induces FOXQ1 in renal tubular epithelial cells, which in turn suppresses Sirt4 and leads to mitochondrial dysfunction, promoting the development of DKD. +genetics_GWAS 36752600 hsa-mir-27a Osteitis Deformans MIR27a exerts its effects on osteoclast differentiation through modulation of Squstm1/p62 whose mutations have been linked to Paget's disease of bone. +genetics_overexpression_promote 36752341 hsa-mir-1283 Her2-Positive Breast Cancer The miR-1283 overexpression prevented the proliferation and enhanced apoptosis of HER2+ breast cancer cells, as well as inhibited tumor growth. +lncRNA target 36752339 hsa-mir-124 Depression We speculated that autophagy was enhanced in the CUMS model of depression and might be mediated by miR-124 targeting Ezh2. +lncRNA target 36752331 hsa-mir-210 Severe Acute Respiratory Syndrome 3p was the single unique lung-specific miRNA, which was found to target the NSP3, NSP4, and NSP13 genes of SARS-CoV-2. +lncRNA target 36752150 hsa-mir-101 Nasopharyngeal Carcinoma 3p was decreased in cisplatin-resistant NPC cells and negatively targeted SOX2. +other 36751856 hsa-mir-4533 Celiac Disease 3p, the longer the diet adherence, the less the expression differed from controls. +other 36751856 hsa-mir-2681 Celiac Disease 3p, the longer the diet adherence, the less the expression differed from controls. +circulation_biomarker_diagnosis_up 36751747 hsa-mir-125a Endometriosis INTERPRETATION & CONCLUSIONS: The present findings suggested that certain circulating miRNAs (miB99b, miR-16, miR-125a, miR-145) might act as indicators and discriminators of endometriosis and endometrioid subtypes of EC and ovarian cancer and might serve as potential biomarkers for early diagnosis and management of these debilitating diseases. +circulation_biomarker_diagnosis_ns 36751747 hsa-mir-16 Carcinoma, Endometrioid INTERPRETATION & CONCLUSIONS: The present findings suggested that certain circulating miRNAs (miB99b, miR-16, miR-125a, miR-145) might act as indicators and discriminators of endometriosis and endometrioid subtypes of EC and ovarian cancer and might serve as potential biomarkers for early diagnosis and management of these debilitating diseases. +other 36751747 hsa-mir-99b Carcinoma, Endometrioid In ECO group, downregulated expression of miR-16 and miR-125a (P<0.05) was observed, whereas miR-99b, miR-143 and miR-145 were upregulated (P<0.05). miR-145 showed diagnostic power for ECO, and for endometrioid EC, miR-16, miR-99b, miR-125a and miR-145 showed diagnostic potential. +circulation_biomarker_diagnosis_ns 36751747 hsa-mir-145 Carcinoma, Endometrioid INTERPRETATION & CONCLUSIONS: The present findings suggested that certain circulating miRNAs (miB99b, miR-16, miR-125a, miR-145) might act as indicators and discriminators of endometriosis and endometrioid subtypes of EC and ovarian cancer and might serve as potential biomarkers for early diagnosis and management of these debilitating diseases. +circulation_biomarker_diagnosis_up 36751747 hsa-mir-145 Endometriosis INTERPRETATION & CONCLUSIONS: The present findings suggested that certain circulating miRNAs (miB99b, miR-16, miR-125a, miR-145) might act as indicators and discriminators of endometriosis and endometrioid subtypes of EC and ovarian cancer and might serve as potential biomarkers for early diagnosis and management of these debilitating diseases. +circulation_biomarker_diagnosis_ns 36751747 hsa-mir-125a Carcinoma, Endometrioid INTERPRETATION & CONCLUSIONS: The present findings suggested that certain circulating miRNAs (miB99b, miR-16, miR-125a, miR-145) might act as indicators and discriminators of endometriosis and endometrioid subtypes of EC and ovarian cancer and might serve as potential biomarkers for early diagnosis and management of these debilitating diseases. +other 36751048 hsa-mir-646 Hypertension Our findings illustrated the specific molecular mechanism of miR-3646 regulating hypertension. +exosome 36750776 hsa-mir-874 Kidney Diseases CONCLUSION: The collective findings of the present study demonstrate that HucMSC-Exos can regulate necroptosis through miR3p to attenuate renal tubular epithelial cell injury and enhance repair, providing new therapeutic modalities and ideas for the treatment of AKI and the process of AKI to CKD transformation to mitigate renal damage. +exosome 36750776 hsa-mir-874 Acute Kidney Injury CONCLUSION: The collective findings of the present study demonstrate that HucMSC-Exos can regulate necroptosis through miR3p to attenuate renal tubular epithelial cell injury and enhance repair, providing new therapeutic modalities and ideas for the treatment of AKI and the process of AKI to CKD transformation to mitigate renal damage. +exosome 36750722 hsa-mir-4536 Uterine Cervical Neoplasms HKF-derived exosomes carried miR5p to CC cells and thereby inhibited PDHB-AS expression. +other 36750632 hsa-mir-1236 Ovarian Neoplasms CONCLUSIONS: Our results provide evidence for the translational involvement of miR-1236 in the lymphangiogenesis of OC by regulating lymphangiogenesis-related factors and support the clinical importance of miR-1236 as a new diagnostic and prognostic biomarker for OC. +genetics_overexpression_promote 36750528 hsa-mir-155 Spinal Cord Injuries 5p overexpression promoted astrocyte activation and glial scarring in an SCI model. +lncRNA target 36750423 hsa-mir-181a Diabetes Mellitus Aim: The aim of this study is to investigate the mechanism and interaction of microRNA-181a (miR-181a), toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-kappaB) in gastric hypersensitivity in diabetic rats. (4) Intrathecal injection of miR-181a agomir down-regulated the expression of TLR4, reduced the hyper-excitability of gastric-specific neurons, and alleviated gastric hypersensitivity. +transcription factor target 36750173 hsa-mir-874 Breast Neoplasms Through analysis, we found that miR +tissue_expression_up 36750001 hsa-mir-194 COVID-19 METHODS: In this study, T-box expressed in T cells (T-bet), GATA binding protein 3, The retinoid orphan receptor gamma t (RORgammat), forkhead box P3 (FOXP3), interleukin (IL)-17A, IL-8, and CC ligand 20 (CCL20) mRNA levels and, miR-155 and miR-194 levels were evaluated in 70 patients suffered from severe coronavirus disease 2019 (COVID-19) and 70 healthy subjects using Real-Time qPCR technique. MiR-194 may play crucial roles in regulation of RORgammat and IL-17A expression in healthy people, the phenomenon that is disrupted in the severe SARS-CoV-2 infected patients. +other 36749775 hsa-mir-22 Liver Neoplasms Overall, our study revealed a novel miR3p/CBL/SPRY2/ERK axis that plays an important role in EMT, cell migration, and invasion of liver cancer cells. +genetics_knock down_promote 36749538 hsa-mir-326 Arthritis, Rheumatoid Knockdown of lncRNA-EWSAT1 could upregulate miR-326 expression and attenuate its proliferation inhibition and apoptosis induction effect in RA-FLS. +circulation_biomarker_diagnosis_ns 36749234 hsa-mir-375 Esophageal Neoplasms receiver operating characteristic analysis demonstrated that miR-375 in EVs could function as a diagnostic marker for ECs, with a higher area under the curve (0.852) than that in plasma. +genetics_GWAS 36749159 hsa-mir-451a Polycythemia 3p expressions and shortened the time taken by cells to enter end-stage differentiation, so as to enhance erythroid differentiation, which may be a pathogenetic mechanism underlying HAPC polycytosis. +genetics_GWAS 36749159 hsa-mir-210 Polycythemia 3p expressions and shortened the time taken by cells to enter end-stage differentiation, so as to enhance erythroid differentiation, which may be a pathogenetic mechanism underlying HAPC polycytosis. +lncRNA target 36749091 hsa-mir-206 gastric adenocarcinoma These findings provide new clues with prognostic and therapeutic implications in STAD and suggest that HOTAIR/miR-206/SOX9 might be a potential new strategy for therapeutic targeting of gastric cancer. +lncRNA target 36748746 hsa-mir-136 Fibrosis, Renal CONCLUSION: Through in vitro and in vivo experiments, the present study was able to successfully prove that tacrolimus upregulates NORAD to compete with miR +lncRNA target 36748628 hsa-mir-9 Carcinoma, Hepatocellular BGH3 axis. +genetics_overexpression_promote 36748323 hsa-mir-200a Endometrial Neoplasms RESULTS: CLOCK expression is disrupted in endometrial cancer, which may be due to miR-15b, miR3p and miR-200a overexpression. +genetics_overexpression_promote 36748323 hsa-mir-15b Endometrial Neoplasms RESULTS: CLOCK expression is disrupted in endometrial cancer, which may be due to miR-15b, miR3p and miR-200a overexpression. +other 36747515 hsa-mir-376a Ovarian Neoplasms CONCLUSION: This study uncovered a novel mechanism that MEG3 sponged miRNA-376a and YBX1 to regulate the expression of RASA1 and exert an effect on the angiogenesis of ovarian cancer. +lncRNA target 36747258 hsa-mir-657 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: LINC00326/miR-657/DKK2 axis signaling blocked tumor-associated functions in NSCLC cells through the targeting Wnt/beta-catenin pathway. +other 36747073 hsa-mir-770 Vasoplegia 5p allowed the ability to distinguish between patients who could and could not develop VS, representing a potential predictive biomarker of VS. +circulation_biomarker_diagnosis_up 36747073 hsa-mir-548c Vasoplegia 3p, and hsa-miR770-5p) were decreased in blood of VASO compared to NONVASO groups. +other 36746925 hsa-mir-4433b Depressive Disorder, Major 5p in ANX cases at wave 2 only. +other 36746925 hsa-mir-4433b Attention Deficit Disorder with Hyperactivity 5p in ANX cases at wave 2 only. +other 36746925 hsa-mir-4433b Anxiety Disorders 5p in ANX cases at wave 2 only. +other 36746925 hsa-mir-28 Attention Deficit Disorder with Hyperactivity 5p in ANX cases at wave 2 only. +other 36746925 hsa-mir-28 Anxiety Disorders 5p in ANX cases at wave 2 only. +other 36746925 hsa-mir-432 Anxiety Disorders 5p in ANX cases at wave 2 only. +other 36746925 hsa-mir-432 Depressive Disorder, Major 5p in ANX cases at wave 2 only. +other 36746925 hsa-mir-28 Depressive Disorder, Major 5p in ANX cases at wave 2 only. +other 36746925 hsa-mir-409 Anxiety Disorders 5p in ANX cases at wave 2 only. +other 36746925 hsa-mir-409 Depressive Disorder, Major 5p in ANX cases at wave 2 only. +other 36746925 hsa-mir-409 Attention Deficit Disorder with Hyperactivity 5p in ANX cases at wave 2 only. +other 36746925 hsa-mir-432 Attention Deficit Disorder with Hyperactivity 5p in ANX cases at wave 2 only. +other 36746221 hsa-mir-206 Intervertebral Disc Degeneration The ceRNA network suggested that lnc-TMEM44-AS1-hsa-miRHDAC4 may be one crucial axis in IDD. +exosome 36746199 hsa-mir-21 Diabetes Mellitus The expression levels of three exosomal miRNAs (hsa-miR-146a-5p, hsa-miR +exosome 36746199 hsa-mir-223 Diabetes Mellitus The expression levels of three exosomal miRNAs (hsa-miR-146a-5p, hsa-miR +exosome 36746199 hsa-mir-146a Diabetes Mellitus The expression levels of three exosomal miRNAs (hsa-miR-146a-5p, hsa-miR +circulation_biomarker_diagnosis_down 36745296 hsa-mir-185 Abortion, Spontaneous CONCLUSIONS: The current study, for the first time, successfully constructed the correlation between maternal circulating exosomal miR +genetics_knock down_promote 36745282 hsa-mir-96 Carcinoma, Hepatocellular 5p knockdown on hepatoma cell malignant behaviors. +genetics_GWAS 36745138 hsa-mir-221 Gout "Unprecedently, a novel UA binding protein - the neuronal apoptosis inhibitor protein (NAIP) - is suggested as responsible for the asymptomatic hyperuricemia paradox.Abbreviation: beta2-integrins: leukocyte-specific adhesion molecules; ABCG2: ATP-binding cassete family/breast cancer-resistant protein; ACR: American college of rheumatology; AIM2: absent in melanoma 2, type of pattern recognition receptor; ALPK1: alpha-protein kinase 1; ANGPTL2: angiopoietin-like protein 2; ASC: apoptosis-associated speck-like protein; BIR: baculovirus inhibitor of apoptosis protein repeat; BIRC1: baculovirus IAP repeat-containing protein 1; BIRC2: baculoviral IAP repeat-containing protein 2; C5a: complement anaphylatoxin; cAMP: cyclic adenosine monophosphate; CARD: caspase activation and recruitment domains; CARD8: caspase recruitment domain-containing protein 8; CASP1: caspase 1; CCL3: chemokine (C-C motif) ligand 3; CD14: cluster of differentiation 14; CD44: cluster of differentiation 44; Cg05102552: DNA-methylation site, usually cytosine followed by guanine nucleotides; contains arbitrary identification code; CIDEC: cell death-inducing DNA fragmentation factor-like effector family; CKD: chronic kidney disease; CNV: copy number variation; CPT1A: carnitine palmitoyl transferase - type 1a; CXCL1: chemokine (CXC motif) ligand 1; DAMPs: damage associated molecular patterns; DC: dendritic cells; DNMT(1): maintenance DNA methyltransferase; eQTL: expression quantitative trait loci; ERK1: extracellular signal-regulated kinase 1; ERK2: extracellular signal-regulated kinase 2; EULAR: European league against rheumatism; GMCSF: granulocyte-macrophage colony-stimulating factor; GWAS: global wide association studies; H3K27me3: tri-methylation at the 27th lysine residue of the histone h3 protein; H3K4me1: mono-methylation at the 4th lysine residue of the histone h3 protein; H3K4me3: tri-methylation at the 4th lysine residue of the histone h3 protein; HOTAIR: human gene located between hoxc11 and hoxc12 on chromosome 12; IkappaBalpha: cytoplasmatic protein/Nf-kappab transcription inhibitor; IAP: inhibitory apoptosis protein; IFNgamma: interferon gamma; IL-1beta: interleukin 1 beta; IL-12: interleukin 12; IL-17: interleukin 17; IL18: interleukin 18; IL1R1: interleukin-1 receptor; IL-1Ra: interleukin-1 receptor antagonist; IL-22: interleukin 22; IL-23: interleukin 23; IL23R: interleukin 23 receptor; IL-33: interleukin 33; IL-6: interleukin 6; IMP: inosine monophosphate; INSIG1: insulin-induced gene 1; JNK1: c-jun n-terminal kinase 1; lncRNA: long non-coding ribonucleic acid; LRR: leucine-rich repeats; miR: mature non-coding microRNAs measuring from 20 to 24 nucleotides, animal origin; miR-1: miR followed by arbitrary identification code; miR-145: miR followed by arbitrary identification code; miR-146a: miR followed by arbitrary identification code, ""a"" stands for mir family; ""a"" family presents similar mir sequence to ""b"" family, but different precursors; miR-20b: miR followed by arbitrary identification code; ""b"" stands for mir family; ""b"" family presents similar mir sequence to ""a"" family, but different precursors; miR-221: miR - followed by arbitrary identification code; miR" +genetics_GWAS 36745138 hsa-mir-22 Gout "Unprecedently, a novel UA binding protein - the neuronal apoptosis inhibitor protein (NAIP) - is suggested as responsible for the asymptomatic hyperuricemia paradox.Abbreviation: beta2-integrins: leukocyte-specific adhesion molecules; ABCG2: ATP-binding cassete family/breast cancer-resistant protein; ACR: American college of rheumatology; AIM2: absent in melanoma 2, type of pattern recognition receptor; ALPK1: alpha-protein kinase 1; ANGPTL2: angiopoietin-like protein 2; ASC: apoptosis-associated speck-like protein; BIR: baculovirus inhibitor of apoptosis protein repeat; BIRC1: baculovirus IAP repeat-containing protein 1; BIRC2: baculoviral IAP repeat-containing protein 2; C5a: complement anaphylatoxin; cAMP: cyclic adenosine monophosphate; CARD: caspase activation and recruitment domains; CARD8: caspase recruitment domain-containing protein 8; CASP1: caspase 1; CCL3: chemokine (C-C motif) ligand 3; CD14: cluster of differentiation 14; CD44: cluster of differentiation 44; Cg05102552: DNA-methylation site, usually cytosine followed by guanine nucleotides; contains arbitrary identification code; CIDEC: cell death-inducing DNA fragmentation factor-like effector family; CKD: chronic kidney disease; CNV: copy number variation; CPT1A: carnitine palmitoyl transferase - type 1a; CXCL1: chemokine (CXC motif) ligand 1; DAMPs: damage associated molecular patterns; DC: dendritic cells; DNMT(1): maintenance DNA methyltransferase; eQTL: expression quantitative trait loci; ERK1: extracellular signal-regulated kinase 1; ERK2: extracellular signal-regulated kinase 2; EULAR: European league against rheumatism; GMCSF: granulocyte-macrophage colony-stimulating factor; GWAS: global wide association studies; H3K27me3: tri-methylation at the 27th lysine residue of the histone h3 protein; H3K4me1: mono-methylation at the 4th lysine residue of the histone h3 protein; H3K4me3: tri-methylation at the 4th lysine residue of the histone h3 protein; HOTAIR: human gene located between hoxc11 and hoxc12 on chromosome 12; IkappaBalpha: cytoplasmatic protein/Nf-kappab transcription inhibitor; IAP: inhibitory apoptosis protein; IFNgamma: interferon gamma; IL-1beta: interleukin 1 beta; IL-12: interleukin 12; IL-17: interleukin 17; IL18: interleukin 18; IL1R1: interleukin-1 receptor; IL-1Ra: interleukin-1 receptor antagonist; IL-22: interleukin 22; IL-23: interleukin 23; IL23R: interleukin 23 receptor; IL-33: interleukin 33; IL-6: interleukin 6; IMP: inosine monophosphate; INSIG1: insulin-induced gene 1; JNK1: c-jun n-terminal kinase 1; lncRNA: long non-coding ribonucleic acid; LRR: leucine-rich repeats; miR: mature non-coding microRNAs measuring from 20 to 24 nucleotides, animal origin; miR-1: miR followed by arbitrary identification code; miR-145: miR followed by arbitrary identification code; miR-146a: miR followed by arbitrary identification code, ""a"" stands for mir family; ""a"" family presents similar mir sequence to ""b"" family, but different precursors; miR-20b: miR followed by arbitrary identification code; ""b"" stands for mir family; ""b"" family presents similar mir sequence to ""a"" family, but different precursors; miR-221: miR - followed by arbitrary identification code; miR" +genetics_GWAS 36745138 hsa-mir-146a Gout "Unprecedently, a novel UA binding protein - the neuronal apoptosis inhibitor protein (NAIP) - is suggested as responsible for the asymptomatic hyperuricemia paradox.Abbreviation: beta2-integrins: leukocyte-specific adhesion molecules; ABCG2: ATP-binding cassete family/breast cancer-resistant protein; ACR: American college of rheumatology; AIM2: absent in melanoma 2, type of pattern recognition receptor; ALPK1: alpha-protein kinase 1; ANGPTL2: angiopoietin-like protein 2; ASC: apoptosis-associated speck-like protein; BIR: baculovirus inhibitor of apoptosis protein repeat; BIRC1: baculovirus IAP repeat-containing protein 1; BIRC2: baculoviral IAP repeat-containing protein 2; C5a: complement anaphylatoxin; cAMP: cyclic adenosine monophosphate; CARD: caspase activation and recruitment domains; CARD8: caspase recruitment domain-containing protein 8; CASP1: caspase 1; CCL3: chemokine (C-C motif) ligand 3; CD14: cluster of differentiation 14; CD44: cluster of differentiation 44; Cg05102552: DNA-methylation site, usually cytosine followed by guanine nucleotides; contains arbitrary identification code; CIDEC: cell death-inducing DNA fragmentation factor-like effector family; CKD: chronic kidney disease; CNV: copy number variation; CPT1A: carnitine palmitoyl transferase - type 1a; CXCL1: chemokine (CXC motif) ligand 1; DAMPs: damage associated molecular patterns; DC: dendritic cells; DNMT(1): maintenance DNA methyltransferase; eQTL: expression quantitative trait loci; ERK1: extracellular signal-regulated kinase 1; ERK2: extracellular signal-regulated kinase 2; EULAR: European league against rheumatism; GMCSF: granulocyte-macrophage colony-stimulating factor; GWAS: global wide association studies; H3K27me3: tri-methylation at the 27th lysine residue of the histone h3 protein; H3K4me1: mono-methylation at the 4th lysine residue of the histone h3 protein; H3K4me3: tri-methylation at the 4th lysine residue of the histone h3 protein; HOTAIR: human gene located between hoxc11 and hoxc12 on chromosome 12; IkappaBalpha: cytoplasmatic protein/Nf-kappab transcription inhibitor; IAP: inhibitory apoptosis protein; IFNgamma: interferon gamma; IL-1beta: interleukin 1 beta; IL-12: interleukin 12; IL-17: interleukin 17; IL18: interleukin 18; IL1R1: interleukin-1 receptor; IL-1Ra: interleukin-1 receptor antagonist; IL-22: interleukin 22; IL-23: interleukin 23; IL23R: interleukin 23 receptor; IL-33: interleukin 33; IL-6: interleukin 6; IMP: inosine monophosphate; INSIG1: insulin-induced gene 1; JNK1: c-jun n-terminal kinase 1; lncRNA: long non-coding ribonucleic acid; LRR: leucine-rich repeats; miR: mature non-coding microRNAs measuring from 20 to 24 nucleotides, animal origin; miR-1: miR followed by arbitrary identification code; miR-145: miR followed by arbitrary identification code; miR-146a: miR followed by arbitrary identification code, ""a"" stands for mir family; ""a"" family presents similar mir sequence to ""b"" family, but different precursors; miR-20b: miR followed by arbitrary identification code; ""b"" stands for mir family; ""b"" family presents similar mir sequence to ""a"" family, but different precursors; miR-221: miR - followed by arbitrary identification code; miR" +genetics_GWAS 36745138 hsa-mir-223 Gout "Unprecedently, a novel UA binding protein - the neuronal apoptosis inhibitor protein (NAIP) - is suggested as responsible for the asymptomatic hyperuricemia paradox.Abbreviation: beta2-integrins: leukocyte-specific adhesion molecules; ABCG2: ATP-binding cassete family/breast cancer-resistant protein; ACR: American college of rheumatology; AIM2: absent in melanoma 2, type of pattern recognition receptor; ALPK1: alpha-protein kinase 1; ANGPTL2: angiopoietin-like protein 2; ASC: apoptosis-associated speck-like protein; BIR: baculovirus inhibitor of apoptosis protein repeat; BIRC1: baculovirus IAP repeat-containing protein 1; BIRC2: baculoviral IAP repeat-containing protein 2; C5a: complement anaphylatoxin; cAMP: cyclic adenosine monophosphate; CARD: caspase activation and recruitment domains; CARD8: caspase recruitment domain-containing protein 8; CASP1: caspase 1; CCL3: chemokine (C-C motif) ligand 3; CD14: cluster of differentiation 14; CD44: cluster of differentiation 44; Cg05102552: DNA-methylation site, usually cytosine followed by guanine nucleotides; contains arbitrary identification code; CIDEC: cell death-inducing DNA fragmentation factor-like effector family; CKD: chronic kidney disease; CNV: copy number variation; CPT1A: carnitine palmitoyl transferase - type 1a; CXCL1: chemokine (CXC motif) ligand 1; DAMPs: damage associated molecular patterns; DC: dendritic cells; DNMT(1): maintenance DNA methyltransferase; eQTL: expression quantitative trait loci; ERK1: extracellular signal-regulated kinase 1; ERK2: extracellular signal-regulated kinase 2; EULAR: European league against rheumatism; GMCSF: granulocyte-macrophage colony-stimulating factor; GWAS: global wide association studies; H3K27me3: tri-methylation at the 27th lysine residue of the histone h3 protein; H3K4me1: mono-methylation at the 4th lysine residue of the histone h3 protein; H3K4me3: tri-methylation at the 4th lysine residue of the histone h3 protein; HOTAIR: human gene located between hoxc11 and hoxc12 on chromosome 12; IkappaBalpha: cytoplasmatic protein/Nf-kappab transcription inhibitor; IAP: inhibitory apoptosis protein; IFNgamma: interferon gamma; IL-1beta: interleukin 1 beta; IL-12: interleukin 12; IL-17: interleukin 17; IL18: interleukin 18; IL1R1: interleukin-1 receptor; IL-1Ra: interleukin-1 receptor antagonist; IL-22: interleukin 22; IL-23: interleukin 23; IL23R: interleukin 23 receptor; IL-33: interleukin 33; IL-6: interleukin 6; IMP: inosine monophosphate; INSIG1: insulin-induced gene 1; JNK1: c-jun n-terminal kinase 1; lncRNA: long non-coding ribonucleic acid; LRR: leucine-rich repeats; miR: mature non-coding microRNAs measuring from 20 to 24 nucleotides, animal origin; miR-1: miR followed by arbitrary identification code; miR-145: miR followed by arbitrary identification code; miR-146a: miR followed by arbitrary identification code, ""a"" stands for mir family; ""a"" family presents similar mir sequence to ""b"" family, but different precursors; miR-20b: miR followed by arbitrary identification code; ""b"" stands for mir family; ""b"" family presents similar mir sequence to ""a"" family, but different precursors; miR-221: miR - followed by arbitrary identification code; miR" +genetics_GWAS 36745138 hsa-mir-145 Gout "Unprecedently, a novel UA binding protein - the neuronal apoptosis inhibitor protein (NAIP) - is suggested as responsible for the asymptomatic hyperuricemia paradox.Abbreviation: beta2-integrins: leukocyte-specific adhesion molecules; ABCG2: ATP-binding cassete family/breast cancer-resistant protein; ACR: American college of rheumatology; AIM2: absent in melanoma 2, type of pattern recognition receptor; ALPK1: alpha-protein kinase 1; ANGPTL2: angiopoietin-like protein 2; ASC: apoptosis-associated speck-like protein; BIR: baculovirus inhibitor of apoptosis protein repeat; BIRC1: baculovirus IAP repeat-containing protein 1; BIRC2: baculoviral IAP repeat-containing protein 2; C5a: complement anaphylatoxin; cAMP: cyclic adenosine monophosphate; CARD: caspase activation and recruitment domains; CARD8: caspase recruitment domain-containing protein 8; CASP1: caspase 1; CCL3: chemokine (C-C motif) ligand 3; CD14: cluster of differentiation 14; CD44: cluster of differentiation 44; Cg05102552: DNA-methylation site, usually cytosine followed by guanine nucleotides; contains arbitrary identification code; CIDEC: cell death-inducing DNA fragmentation factor-like effector family; CKD: chronic kidney disease; CNV: copy number variation; CPT1A: carnitine palmitoyl transferase - type 1a; CXCL1: chemokine (CXC motif) ligand 1; DAMPs: damage associated molecular patterns; DC: dendritic cells; DNMT(1): maintenance DNA methyltransferase; eQTL: expression quantitative trait loci; ERK1: extracellular signal-regulated kinase 1; ERK2: extracellular signal-regulated kinase 2; EULAR: European league against rheumatism; GMCSF: granulocyte-macrophage colony-stimulating factor; GWAS: global wide association studies; H3K27me3: tri-methylation at the 27th lysine residue of the histone h3 protein; H3K4me1: mono-methylation at the 4th lysine residue of the histone h3 protein; H3K4me3: tri-methylation at the 4th lysine residue of the histone h3 protein; HOTAIR: human gene located between hoxc11 and hoxc12 on chromosome 12; IkappaBalpha: cytoplasmatic protein/Nf-kappab transcription inhibitor; IAP: inhibitory apoptosis protein; IFNgamma: interferon gamma; IL-1beta: interleukin 1 beta; IL-12: interleukin 12; IL-17: interleukin 17; IL18: interleukin 18; IL1R1: interleukin-1 receptor; IL-1Ra: interleukin-1 receptor antagonist; IL-22: interleukin 22; IL-23: interleukin 23; IL23R: interleukin 23 receptor; IL-33: interleukin 33; IL-6: interleukin 6; IMP: inosine monophosphate; INSIG1: insulin-induced gene 1; JNK1: c-jun n-terminal kinase 1; lncRNA: long non-coding ribonucleic acid; LRR: leucine-rich repeats; miR: mature non-coding microRNAs measuring from 20 to 24 nucleotides, animal origin; miR-1: miR followed by arbitrary identification code; miR-145: miR followed by arbitrary identification code; miR-146a: miR followed by arbitrary identification code, ""a"" stands for mir family; ""a"" family presents similar mir sequence to ""b"" family, but different precursors; miR-20b: miR followed by arbitrary identification code; ""b"" stands for mir family; ""b"" family presents similar mir sequence to ""a"" family, but different precursors; miR-221: miR - followed by arbitrary identification code; miR" +genetics_GWAS 36745138 hsa-mir-20b Gout "Unprecedently, a novel UA binding protein - the neuronal apoptosis inhibitor protein (NAIP) - is suggested as responsible for the asymptomatic hyperuricemia paradox.Abbreviation: beta2-integrins: leukocyte-specific adhesion molecules; ABCG2: ATP-binding cassete family/breast cancer-resistant protein; ACR: American college of rheumatology; AIM2: absent in melanoma 2, type of pattern recognition receptor; ALPK1: alpha-protein kinase 1; ANGPTL2: angiopoietin-like protein 2; ASC: apoptosis-associated speck-like protein; BIR: baculovirus inhibitor of apoptosis protein repeat; BIRC1: baculovirus IAP repeat-containing protein 1; BIRC2: baculoviral IAP repeat-containing protein 2; C5a: complement anaphylatoxin; cAMP: cyclic adenosine monophosphate; CARD: caspase activation and recruitment domains; CARD8: caspase recruitment domain-containing protein 8; CASP1: caspase 1; CCL3: chemokine (C-C motif) ligand 3; CD14: cluster of differentiation 14; CD44: cluster of differentiation 44; Cg05102552: DNA-methylation site, usually cytosine followed by guanine nucleotides; contains arbitrary identification code; CIDEC: cell death-inducing DNA fragmentation factor-like effector family; CKD: chronic kidney disease; CNV: copy number variation; CPT1A: carnitine palmitoyl transferase - type 1a; CXCL1: chemokine (CXC motif) ligand 1; DAMPs: damage associated molecular patterns; DC: dendritic cells; DNMT(1): maintenance DNA methyltransferase; eQTL: expression quantitative trait loci; ERK1: extracellular signal-regulated kinase 1; ERK2: extracellular signal-regulated kinase 2; EULAR: European league against rheumatism; GMCSF: granulocyte-macrophage colony-stimulating factor; GWAS: global wide association studies; H3K27me3: tri-methylation at the 27th lysine residue of the histone h3 protein; H3K4me1: mono-methylation at the 4th lysine residue of the histone h3 protein; H3K4me3: tri-methylation at the 4th lysine residue of the histone h3 protein; HOTAIR: human gene located between hoxc11 and hoxc12 on chromosome 12; IkappaBalpha: cytoplasmatic protein/Nf-kappab transcription inhibitor; IAP: inhibitory apoptosis protein; IFNgamma: interferon gamma; IL-1beta: interleukin 1 beta; IL-12: interleukin 12; IL-17: interleukin 17; IL18: interleukin 18; IL1R1: interleukin-1 receptor; IL-1Ra: interleukin-1 receptor antagonist; IL-22: interleukin 22; IL-23: interleukin 23; IL23R: interleukin 23 receptor; IL-33: interleukin 33; IL-6: interleukin 6; IMP: inosine monophosphate; INSIG1: insulin-induced gene 1; JNK1: c-jun n-terminal kinase 1; lncRNA: long non-coding ribonucleic acid; LRR: leucine-rich repeats; miR: mature non-coding microRNAs measuring from 20 to 24 nucleotides, animal origin; miR-1: miR followed by arbitrary identification code; miR-145: miR followed by arbitrary identification code; miR-146a: miR followed by arbitrary identification code, ""a"" stands for mir family; ""a"" family presents similar mir sequence to ""b"" family, but different precursors; miR-20b: miR followed by arbitrary identification code; ""b"" stands for mir family; ""b"" family presents similar mir sequence to ""a"" family, but different precursors; miR-221: miR - followed by arbitrary identification code; miR" +genetics_GWAS 36745138 hsa-mir-1 Gout "Unprecedently, a novel UA binding protein - the neuronal apoptosis inhibitor protein (NAIP) - is suggested as responsible for the asymptomatic hyperuricemia paradox.Abbreviation: beta2-integrins: leukocyte-specific adhesion molecules; ABCG2: ATP-binding cassete family/breast cancer-resistant protein; ACR: American college of rheumatology; AIM2: absent in melanoma 2, type of pattern recognition receptor; ALPK1: alpha-protein kinase 1; ANGPTL2: angiopoietin-like protein 2; ASC: apoptosis-associated speck-like protein; BIR: baculovirus inhibitor of apoptosis protein repeat; BIRC1: baculovirus IAP repeat-containing protein 1; BIRC2: baculoviral IAP repeat-containing protein 2; C5a: complement anaphylatoxin; cAMP: cyclic adenosine monophosphate; CARD: caspase activation and recruitment domains; CARD8: caspase recruitment domain-containing protein 8; CASP1: caspase 1; CCL3: chemokine (C-C motif) ligand 3; CD14: cluster of differentiation 14; CD44: cluster of differentiation 44; Cg05102552: DNA-methylation site, usually cytosine followed by guanine nucleotides; contains arbitrary identification code; CIDEC: cell death-inducing DNA fragmentation factor-like effector family; CKD: chronic kidney disease; CNV: copy number variation; CPT1A: carnitine palmitoyl transferase - type 1a; CXCL1: chemokine (CXC motif) ligand 1; DAMPs: damage associated molecular patterns; DC: dendritic cells; DNMT(1): maintenance DNA methyltransferase; eQTL: expression quantitative trait loci; ERK1: extracellular signal-regulated kinase 1; ERK2: extracellular signal-regulated kinase 2; EULAR: European league against rheumatism; GMCSF: granulocyte-macrophage colony-stimulating factor; GWAS: global wide association studies; H3K27me3: tri-methylation at the 27th lysine residue of the histone h3 protein; H3K4me1: mono-methylation at the 4th lysine residue of the histone h3 protein; H3K4me3: tri-methylation at the 4th lysine residue of the histone h3 protein; HOTAIR: human gene located between hoxc11 and hoxc12 on chromosome 12; IkappaBalpha: cytoplasmatic protein/Nf-kappab transcription inhibitor; IAP: inhibitory apoptosis protein; IFNgamma: interferon gamma; IL-1beta: interleukin 1 beta; IL-12: interleukin 12; IL-17: interleukin 17; IL18: interleukin 18; IL1R1: interleukin-1 receptor; IL-1Ra: interleukin-1 receptor antagonist; IL-22: interleukin 22; IL-23: interleukin 23; IL23R: interleukin 23 receptor; IL-33: interleukin 33; IL-6: interleukin 6; IMP: inosine monophosphate; INSIG1: insulin-induced gene 1; JNK1: c-jun n-terminal kinase 1; lncRNA: long non-coding ribonucleic acid; LRR: leucine-rich repeats; miR: mature non-coding microRNAs measuring from 20 to 24 nucleotides, animal origin; miR-1: miR followed by arbitrary identification code; miR-145: miR followed by arbitrary identification code; miR-146a: miR followed by arbitrary identification code, ""a"" stands for mir family; ""a"" family presents similar mir sequence to ""b"" family, but different precursors; miR-20b: miR followed by arbitrary identification code; ""b"" stands for mir family; ""b"" family presents similar mir sequence to ""a"" family, but different precursors; miR-221: miR - followed by arbitrary identification code; miR" +lncRNA target 36744815 hsa-mir-10a Uterine Cervical Neoplasms This miR-10a-5p-mediated post-transcriptional regulation of UBE2I is involved in the tumorigenesis, invasion and migration of human cervical cancer.What are the implications of these findings for clinical practice and/or further research? These findings provide mechanistic insights into how miR-10a-5p regulates cervical cancer hyper-proliferation and metastasis, as well as a new target for clinical treatment. +transcription factor target 36744005 hsa-mir-25 Schizophrenia 3p is very likely to be associated with schizophrenia, revealing potential targets for the treatment and clinical diagnosis of schizophrenia. +lncRNA target 36743910 hsa-mir-124 Alzheimer Disease Moreover, for the second strategy, we show other critical miRNAs can be made apparent through the disease's comorbidities, and in this case, overall, the hsa-mir-103a-3p models work well for all the datasets, especially in T2D, while the hsa-mir3p models achieved the best scores for the AD datasets. +lncRNA target 36743910 hsa-mir-103a Alzheimer Disease Moreover, for the second strategy, we show other critical miRNAs can be made apparent through the disease's comorbidities, and in this case, overall, the hsa-mir-103a-3p models work well for all the datasets, especially in T2D, while the hsa-mir3p models achieved the best scores for the AD datasets. +lncRNA target 36743910 hsa-mir-124 Diabetes Mellitus, Type 2 Moreover, for the second strategy, we show other critical miRNAs can be made apparent through the disease's comorbidities, and in this case, overall, the hsa-mir-103a-3p models work well for all the datasets, especially in T2D, while the hsa-mir +lncRNA target 36743367 hsa-mir-204 Carcinoma, Non-Small-Cell Lung The influence brought from gene LOC285758 knocking out could be reversed through suppressing miRNA-204, causing up-regulated CDK6 as well as LOC285758 expression in NSCLC tissues. +other 36743290 hsa-mir-376a-1 Autism Spectrum Disorder Furthermore, we verify that A-to-I edited hsa-mir-376a-5p directly represses GPR85 and NAPB, which may contribute to the abnormal neuronal development of ASD patients. +other 36743290 hsa-mir-376a Autism Spectrum Disorder Furthermore, we verify that A-to-I edited hsa-mir-376a-5p directly represses GPR85 and NAPB, which may contribute to the abnormal neuronal development of ASD patients. +circulation_biomarker_diagnosis_down 36742232 hsa-mir-203a Breast Neoplasms In this study, the plasma levels of miR-129 and miR-203a were evaluated to investigate their diagnostic potential in breast cancer and its metastasis. +circulation_biomarker_diagnosis_ns 36742227 hsa-mir-21 Vitiligo CONCLUSION: Peripheral blood of vitiligo patients-derived exosomal miR +genetics_knock down_promote 36742154 hsa-mir-34a Spinal Cord Injuries TERC knockdown facilitated the regeneration of neuron tissues yet inhibited inflammation in SCI through Akt activation and p-38 inhibition via the miR-34a-5p/XBP-1 axis. +genetics_overexpression_suppress 36742139 hsa-mir-148a Intervertebral Disc Degeneration We aimed to investigate the effects of miR-148a-3p overexpression on IDD progression. +target gene 36741904 hsa-mir-150 Rhabdomyosarcoma Long non-coding RNA SNHG9 regulates viral replication in rhabdomyosarcoma cells infected with enterovirus D68 via miR-150-5p/c-Fos axis. +other 36741376 hsa-mir-27a Colonic Neoplasms CONCLUSION: Our results indicated that CD55 is regulated by TFCP2, NF-kappaB, miR-27a-3p, and several immune-related genes, which in turn affects colon cancer. +lncRNA target 36741266 hsa-mir-214 Carcinoma, Non-Small-Cell Lung Conclusions: Our results suggest that Dvl1 is a potential therapeutic target for NSCLC and that miR-214 plays an inhibitory role in Dvl1-mediated activation of Wnt/beta-catenin signalling in NSCLC cells, which could affect NSCLC progression. +target gene 36741009 hsa-mir-106a Ovarian Neoplasms circFAM169A/miR-106a-5p, miR-519d-3p mediated low expression of RPS6KA2 could affect the proliferation of ovarian cancer cells via p38/MAPK signaling pathway. +target gene 36741009 hsa-mir-519d Ovarian Neoplasms circFAM169A/miR-106a-5p, miR-519d-3p mediated low expression of RPS6KA2 could affect the proliferation of ovarian cancer cells via p38/MAPK signaling pathway. +circulation_biomarker_diagnosis_ns 36740798 hsa-mir-499 Heart Failure, Chronic Injections of 6 mL/kg Rhodiola rosea reduce plasma levels of miR +circulation_biomarker_diagnosis_ns 36740798 hsa-mir-423 Heart Failure, Chronic Injections of 6 mL/kg Rhodiola rosea reduce plasma levels of miR +circulation_biomarker_diagnosis_ns 36740798 hsa-mir-210 Heart Failure, Chronic Injections of 6 mL/kg Rhodiola rosea reduce plasma levels of miR +lncRNA target 36740760 hsa-mir-584 Carcinoma, Hepatocellular 3p inhibitor could reverse the effects of LINC00607 downregulation in HCC through rescue experiments. +transcription factor target 36740725 hsa-mir-223 Obesity We infer that TBT induced miR-223 expression and increased adipogenesis in MSCs through the PPARgamma pathway and that transgenerationally increased expression of miR-223 plays an important role in the development of obesity caused by TBT exposure. +genetics_overexpression_promote 36740679 hsa-mir-140 Stomach Neoplasms Overexpression of miR +other 36740569 hsa-mir-146a Lupus Erythematosus, Systemic Although we shed some light on the role of miR-146a in SLE, further study is recommended to improve our results. +exosome 36739582 hsa-mir-29b Myocardial Infarction To this end, a biocompatible microneedle (MN) patch based on gelatin is fabricated to load exosomes containing microRNA-29b (miR-29b) mimics with antifibrotic activity to prevent excessive cardiac fibrosis after MI. +exosome 36739582 hsa-mir-29b Cardiomyopathies To this end, a biocompatible microneedle (MN) patch based on gelatin is fabricated to load exosomes containing microRNA-29b (miR-29b) mimics with antifibrotic activity to prevent excessive cardiac fibrosis after MI. +transcription factor target 36739077 hsa-mir-128 Breast Neoplasms Therefore, EMPA abrogates breast cancer stemness by inactivating SP1 and PKM2 via enhanced miR +other 36738648 hsa-mir-4732 Schizophrenia 3p were confirmed to be significantly up-regulated, and miR-30e-3p and miR-23a-3p were down-regulated in SCZ patients. +other 36738648 hsa-mir-939 Schizophrenia 3p were confirmed to be significantly up-regulated, and miR-30e-3p and miR-23a-3p were down-regulated in SCZ patients. +other 36738648 hsa-mir-142 Schizophrenia 3p were confirmed to be significantly up-regulated, and miR-30e-3p and miR-23a-3p were down-regulated in SCZ patients. +other 36738648 hsa-mir-23a Schizophrenia 3p were confirmed to be significantly up-regulated, and miR-30e-3p and miR-23a-3p were down-regulated in SCZ patients. +genetics_knock down_promote 36738516 hsa-mir-1238 Prostatic Neoplasms Also, overexpression of SEPT2 abolished the suppressive impacts of miR +other 36738390 hsa-mir-10395 Stomach Neoplasms 3p could be used as biomarkers predicting PM and NIPS efficacy and are involved in GC metastasis and chemoresistance. +other 36738390 hsa-let-7g Stomach Neoplasms 3p could be used as biomarkers predicting PM and NIPS efficacy and are involved in GC metastasis and chemoresistance. +lncRNA target 36738282 hsa-mir-1256 Esophageal Neoplasms CircKRT1 acted as a sponge for miR-1256 in EC, and in-miR-1256 abolished the inhibitory effect of circKRT14 suppression on EC cell progression. +genetics_knock down_promote 36738165 hsa-mir-1278 Nasopharyngeal Carcinoma Circ_0000285 knockdown-mediated anti-tumor effects in NPC cells could be largely reversed by silencing of miR-1278 or overexpression of FNDC3B. +genetics_overexpression_promote 36737832 hsa-mir-455 Squamous Cell Carcinoma of Head and Neck 5p overexpression and PDZK1IP1 inhibition promoted collective OSCC cell migration. +lncRNA target 36737782 hsa-mir-26b Stomach Neoplasms CONCLUSION: The newly identified miR-26b-5p-PDE4B/CDK8-STAT3 feedback loop plays an important role in inflammation-related GC progression and may serve as a promising therapeutic target for GC. +lncRNA target 36737651 hsa-mir-92b Squamous Cell Carcinoma of Head and Neck Finally, 4 significantly up-regulated miRNAs (miR-92a-3p, miR-92b-3p, miR-320c and miR5p) were identified from OSCC patients via validation in the Chungnam National University Hospital cohort. +lncRNA target 36737651 hsa-mir-92a Squamous Cell Carcinoma of Head and Neck Finally, 4 significantly up-regulated miRNAs (miR-92a-3p, miR-92b-3p, miR-320c and miR5p) were identified from OSCC patients via validation in the Chungnam National University Hospital cohort. +lncRNA target 36737651 hsa-mir-320c Squamous Cell Carcinoma of Head and Neck Finally, 4 significantly up-regulated miRNAs (miR-92a-3p, miR-92b-3p, miR-320c and miR5p) were identified from OSCC patients via validation in the Chungnam National University Hospital cohort. +lncRNA target 36737507 hsa-let-7c Carcinoma, Hepatocellular CONCLUSION: Let-7c-5p has been proved to suppress HCC by down-regulating immune-related CDCA8, which will help understand the pathogenesis of HCC and develop drugs for its treatment. +other 36737428 hsa-mir-1208 Breast Neoplasms Mechanistically, TMEM105 regulated LDHA expression by sponging miR-1208, which further promoted cell glycolysis and BCLM. +circRNA target 36737402 hsa-mir-874 Esophageal Neoplasms 3p/ENAH axis, which might provide novel therapeutic targets for esophageal cancer intervention. +circulation_biomarker_diagnosis_ns 36736597 hsa-mir-200c sporatic amyotrophic lateral sclerosis RESULTS: Our results show a dysregulation of a signaling pathway involving ZEB1-AS1/hsa-miR-200c/beta-Catenin in peripheral blood mononuclear cells and in induced pluripotent stem cells-derived neural stem cells from sALS patients. +lncRNA target 36736544 hsa-mir-206 Anxiety Disorders CONCLUSIONS: In conclusion, the key findings of the current study demonstrate that gut microbiota aggravated anxiety-like behaviors via the miR +other 36736231 hsa-mir-219 Cognition Disorders This study aimed to clarify whether NP exposure could lead to cognitive dysfunction and synaptic plasticity impairment, and also explore the mechanism of microRNA (miR)- 219a-5p regulation of N-methyl-D-aspartate receptor (NMDAR) in NP-induced synaptic plasticity impairment in vivo and in vitro. +other 36736231 hsa-mir-219a Cognition Disorders This study aimed to clarify whether NP exposure could lead to cognitive dysfunction and synaptic plasticity impairment, and also explore the mechanism of microRNA (miR)- 219a-5p regulation of N-methyl-D-aspartate receptor (NMDAR) in NP-induced synaptic plasticity impairment in vivo and in vitro. +genetics_knock down_promote 36735765 hsa-mir-92a Ovarian Neoplasms MiR-92a not only promotes the proliferation, colony formation and paclitaxel resistance of SKOV3-Tax cells in OC, but also inhibits apoptosis, and it may be related to the regulation of the PTEN/Akt signaling pathway. +other 36735713 hsa-mir-199a Heart Failure The miR-199a NP downregulated levels of HSP, which had a certain protective effect against HF and had a high clinical-adoption and promotion value. +other 36735415 hsa-mir-370 Spinal Cord Injuries circ_0013613 can promote the recovery of SCI by regulating miR3p/CASP1 to mediate neuronal pyroptosis. +tissue_expression_ns 36735043 hsa-mir-150 Pyruvate Kinase Deficiency of Red Cells 5p silencing also mitigated the impact of circVRK1 deficiency on OGD-evoked injury. +lncRNA target 36734950 hsa-mir-125b Leukemia miR-125b-5p inhibited leukemia cell proliferation and boosted apoptosis through decreasing MCL1. +transcription factor target 36734882 hsa-mir-181a Fractures, Bone These findings have substantial implications for the strategies targeting miR-181a-5p to prevent osteoporosis and potential related fractures. +lncRNA target 36734882 hsa-mir-181a Osteoporosis These findings have substantial implications for the strategies targeting miR-181a-5p to prevent osteoporosis and potential related fractures. +other 36734859 hsa-mir-411 Keloid 5p/JAG1 axis. +other 36734858 hsa-mir-873 Osteosarcoma 5p/ROCK1 axis in OS. +genetics_overexpression_suppress 36734856 hsa-mir-3175 Lung Neoplasms Overexpressing miR-3175 or silencing SEMA6A could hamper the effects of LINC00312 on lung cancer cells. LINC00312 inhibits lung cancer occurrence and progression via the miR-3175/SEMA6A axis. +genetics_knock down_promote 36734855 hsa-mir-105 Carcinoma, Non-Small-Cell Lung 5p or knockdown of GIMAP6 reversed the inhibition of lncRNA EPB41L4A-AS1 overexpression on NSCLC cell proliferation. +genetics_overexpression_promote 36734854 hsa-mir-873 Uterine Cervical Neoplasms Moreover, overexpression of LMCD1-AS1 promoted CC cell proliferation and EMT process through the regulation of miR +other 36734696 hsa-mir-760 Carcinoma, Hepatocellular "The article ""LINC01296 promotes the proliferation and invasion by regulating microRNA-760 expression and predicts poor prognosis of hepatocellular carcinoma"", by Z.-C." +other 36734535 hsa-let-7b Arthritis, Psoriatic Four miRNAs (miR-19b-3p, miR5p, miR-92a-3p and let-7b-5p) were significantly different regulated between PsO and PsA. +other 36734535 hsa-mir-21 Arthritis, Psoriatic Four miRNAs (miR-19b-3p, miR5p, miR-92a-3p and let-7b-5p) were significantly different regulated between PsO and PsA. +other 36734535 hsa-mir-92a psoriasis 1 Four miRNAs (miR-19b-3p, miR5p, miR-92a-3p and let-7b-5p) were significantly different regulated between PsO and PsA. +other 36734535 hsa-mir-92a Arthritis, Psoriatic Four miRNAs (miR-19b-3p, miR5p, miR-92a-3p and let-7b-5p) were significantly different regulated between PsO and PsA. +other 36734535 hsa-mir-19b psoriasis 1 Four miRNAs (miR-19b-3p, miR5p, miR-92a-3p and let-7b-5p) were significantly different regulated between PsO and PsA. +other 36734535 hsa-mir-21 psoriasis 1 Four miRNAs (miR-19b-3p, miR5p, miR-92a-3p and let-7b-5p) were significantly different regulated between PsO and PsA. +other 36734535 hsa-let-7b psoriasis 1 Four miRNAs (miR-19b-3p, miR5p, miR-92a-3p and let-7b-5p) were significantly different regulated between PsO and PsA. +other 36734535 hsa-mir-19b Arthritis, Psoriatic Four miRNAs (miR-19b-3p, miR5p, miR-92a-3p and let-7b-5p) were significantly different regulated between PsO and PsA. +lncRNA target 36734386 hsa-mir-381 Reperfusion Injury, Cerebral Ischemia CONCLUSIONS: The present research shows that LncRNA HCG11 silencing protects against cerebral ischemia/reperfusion injury through miR3p to regulate p53. +genetics_knock down_suppress 36734233 hsa-mir-210 Ischemic Stroke TET2 knockdown reversed the protective effects of miR210 inhibition or miR210 KO on ischemic stroke-induced brain infarct size and neurobehavioral deficits. +genetics_knock down_suppress 36734233 hsa-mir-210 Parkinson Disease TET2 knockdown reversed the protective effects of miR210 inhibition or miR210 KO on ischemic stroke-induced brain infarct size and neurobehavioral deficits. +lncRNA target 36734072 hsa-mir-671 Alzheimer Disease Whether GABA can inhibit the reduction in CNTN1/2 expression by regulating CEBPalpha/circAPLP2/miR +other 36733403 hsa-mir-204 Diabetes Mellitus, Type 2 The regulation of TXNIP, miR-204, and MafA might play an important role in the mechanism of diabetes remission following bariatric surgery. +circulation_biomarker_diagnosis_up 36733250 hsa-mir-671 Pneumonia 5p dramatically reduced the ameliorative effect of extracellular vesicles released by menstrual blood-derived stem cells on lipopolysaccharide (LPS)-induced pulmonary inflammatory injury. +circulation_biomarker_diagnosis_ns 36733244 hsa-mir-92b Pancreatitis Further validation studies revealed that six miRNAs (miR-216a, miR-216b, miR-217, miR92b, miR-375 and miR-148a) were differentially expressed in the serum samples from patients with acute pancreatitis. +genetics_knock down_promote 36733207 hsa-mir-99a Carcinoma, Hepatocellular Finally, the experimental results of overexpression and knockdown confirmed that miRNA-99a-5p could inhibit cell proliferation in HCC, which also suggested that it may be an important tumor suppressor in HCC. CONCLUSION: MiRNA-99a-5p was negatively correlated with HCC progression and could act as a novel therapeutic target for HCC. +target gene 36732923 hsa-mir-361 Triple Negative Breast Neoplasms LncRNA PRKCQ-AS1 regulates paclitaxel resistance in triple-negative breast cancer cells through miR-361-5p/PIK3C3 mediated autophagy. +other 36732514 hsa-mir-6125 Parkinson Disease Moreover, we identified four miRNAs with relatively high discriminative ability (AUC = 0.82) between non-pheno-converted DaT-positive G2019S carriers and pheno-converted L2PD patients (miR-4505, miR-8069, miR-6125, and miR-451a), which hold potential as early progression biomarkers for PD. +other 36732514 hsa-mir-8069 Parkinson Disease Moreover, we identified four miRNAs with relatively high discriminative ability (AUC = 0.82) between non-pheno-converted DaT-positive G2019S carriers and pheno-converted L2PD patients (miR-4505, miR-8069, miR-6125, and miR-451a), which hold potential as early progression biomarkers for PD. +other 36732514 hsa-mir-4505 Parkinson Disease Moreover, we identified four miRNAs with relatively high discriminative ability (AUC = 0.82) between non-pheno-converted DaT-positive G2019S carriers and pheno-converted L2PD patients (miR-4505, miR-8069, miR-6125, and miR-451a), which hold potential as early progression biomarkers for PD. +target gene 36732504 hsa-mir-7 Colorectal Neoplasms MiR-7-5p/KLF4 signaling inhibits stemness and radioresistance in colorectal cancer. +lncRNA target 36732450 hsa-mir-125b Lupus Erythematosus, Systemic 3p, miR-34a, miR-346, and miR-125b) in SLE PBMC cells was analyzed under proinflammatory cytokine IFNgamma treatment, and miR-125b was identified as the target miRNA. +lncRNA target 36732429 hsa-mir-218 Brain Ischemia 5p and up-regulated SMURF2, thus alleviating cerebral ischemic injury. +lncRNA target 36731227 hsa-mir-223 Diabetic Nephropathies 3p associated with IL6T mRNA and attenuated the progression of DKD by suppressing the downstream STAT3 activation, indicative of the implication of miR +genetics_knock down_promote 36730936 hsa-mir-195 Esophageal Squamous Cell Carcinoma Finally, in vivo experiments were utilized to validate that knockdown of DGCR5 suppressed the Warburg effect via targeting of the miR-195/HK2 axis to increase the radiosensitivity of ESCC. +transcription factor target 36730721 hsa-mir-3 Non-alcoholic Fatty Liver Disease Obtained results showed that resveratrol and atorvastatin combination therapy can improve nonalcoholic fatty liver disease by targeting genes involved in cholesterol metabolism and miR33. +genetics_knock down_suppress 36730637 hsa-mir-942 Ovarian Neoplasms Circ-PIP5K1A knockdown reduced the resistance to DDP in OC via regulating miR +genetics_knock down_promote 36730555 hsa-mir-516b Thyroid Neoplasms Finally, we demonstrated that the miR-516b-5p inhibitor was capable of reversing ARAP1-AS1-knockdown's repressive effects on TC cell development by means of regulating PDE5A expression. +genetics_knock down_promote 36730544 hsa-mir-223 Carcinoma, Ovarian Epithelial In addition, LARP4 knockdown increased the proliferation, migration, and invasion of EOC cells inhibited by miR +lncRNA target 36730426 hsa-mir-520d Colorectal Neoplasms PROX1-AS1 facilitated CRC progression and immune escape by targeting miR-520d. To sum up, this study affirmed that PROX1-AS1 could absorb miR-520d to upregulate PD-L1 in CRC, thereby promoting tumor progression and immune escape. +exosome 36730375 hsa-mir-1911 Adenocarcinoma of Lung The present study demonstrated that M2 macrophage-derived exosomal miR +genetics_overexpression_promote 36730287 hsa-mir-498 Carcinoma, Hepatocellular Moreover, ODC1 was a direct target of miR-498 and ODC1 overexpression abated the anticancer roles of miR-498 in HCC. +transcription factor target 36730262 hsa-mir-29a Deltaretrovirus Infections The objective of this study was to determine the relative expression of BLV-encoded miRNA blv-miR-b4-3p, the host analogous miRNA bo-miR-29a and a couple of potential target mRNAs (HBP-1 and PXDN, with anti-tumorigenic function in B-cells), in cattle naturally infected with BLV compared to uninfected animals (control group). Considering the similar expression of endogenous bo-miR-29a in both animal groups, the downregulation of PXDN in BLV-naturally infected cattle could be linked to blv-miR-b4-3p expression in these animals. +circRNA target 36729977 hsa-mir-377 Esophageal Neoplasms Our study found that circ_0058063 could regulate the expression of HOXA1 by targeting miR +genetics_knock down_suppress 36729852 hsa-mir-508 Ovarian Neoplasms 3p overturned the effects of circSETDB1 knockdown on the Ptx resistance of ovarian cancer cells. +lncRNA target 36729201 hsa-mir-17 Wounds and Injuries 5p/Ulk1 axis can promote the wound-healing and suggest that lncRNA Neat1 loaded by ADSCs-exo might be a potential therapeutic target for skin no-healing wounds. +lncRNA target 36729201 hsa-mir-17 Wounds, Nonpenetrating CONCLUSIONS: Collectively, these results reveal a novel molecular mechanism that the autophagy pathway enhanced by Neat1/miR5p/Ulk1 axis can promote the wound-healing and suggest that lncRNA Neat1 loaded by ADSCs-exo might be a potential therapeutic target for skin no-healing wounds. +other 36729102 hsa-mir-625 Uterine Cervical Neoplasms Circular RNA circ_0000212 accelerates cervical cancer progression by acting as a miR-625-5p sponge to upregulate PTP4A1. +lncRNA target 36728962 hsa-mir-145 Carcinoma, Endometrioid CONCLUSION: Circ_0005667 enhanced DDP resistance in EC by elevating IGF2BP1 through sponging miR +circulation_biomarker_prognosis_ns 36728308 hsa-mir-221 Thyroid Neoplasms CONCLUSIONS: CRISPR-based detection of miR-146b and miR-221 in the blood of thyroid cancer patients is a reliable and noninvasive tool for real-time assessment and prognostication that has great potential to provide a direct impact on the care of these patients. +circulation_biomarker_prognosis_ns 36728308 hsa-mir-146b Thyroid Neoplasms CONCLUSIONS: CRISPR-based detection of miR-146b and miR-221 in the blood of thyroid cancer patients is a reliable and noninvasive tool for real-time assessment and prognostication that has great potential to provide a direct impact on the care of these patients. +other 36728308 hsa-mir-146b Thyroid Diseases The miRNA risk score and prognostic nomogram showed higher accuracy in predicting lymph node metastases (miR-146b: area under the curve [AUC] 0.816, sensitivity 76.9%; miR-221: AUC 0.740, sensitivity 79.5%) and recurrence (miR-146b: AUC 0.921, sensitivity 75.0%; miR-221: AUC 0.756, sensitivity 70.0%; p < 0.001) than staging and American Thyroid Association risk stratification. +other 36728308 hsa-mir-221 Thyroid Diseases The miRNA risk score and prognostic nomogram showed higher accuracy in predicting lymph node metastases (miR-146b: area under the curve [AUC] 0.816, sensitivity 76.9%; miR-221: AUC 0.740, sensitivity 79.5%) and recurrence (miR-146b: AUC 0.921, sensitivity 75.0%; miR-221: AUC 0.756, sensitivity 70.0%; p < 0.001) than staging and American Thyroid Association risk stratification. +transcription factor target 36728287 hsa-mir-200b Cholangiocarcinoma CONCLUSION: L-Fucose inhibited the progression of CCA via the miR-200b/MAPK7 and signal transducer and activator of transcription 3 signaling pathways. +circRNA target 36728267 hsa-mir-92a Pre-Eclampsia The circRNA_06354/hsa-miR-92a-3p/VEGF-A axis might be a therapeutic target in the prevention and treatment of EOPE. +genetics_GWAS 36727832 hsa-mir-4736 Carcinoma, Pancreatic Ductal Furthermore, blocking miR-4736 suppresses tumor growth in genetically engineered KPC (LSL-KrasG12D/+, LSL-Trp53R172H/+, and Pdx +circRNA target 36727737 hsa-mir-520h Carcinoma, Non-Small-Cell Lung MiR-520h restoration impaired gefitinib resistance and suppressed NSCLC cell proliferation, migration, and invasion by repressing YAP1. +other 36727735 hsa-mir-95 Cholangiocarcinoma 3p/TRAF3 axis and may become a novel approach for treating CHOL. +genetics_knock down_suppress 36727613 hsa-mir-509 Breast Neoplasms CONCLUSION: Circ_0005273 knockdown might repress BC cell malignant behaviors by regulating the miR +other 36727428 hsa-mir-424 Nasopharyngeal Carcinoma 5p expression. +other 36727260 hsa-mir-29 Glioblastoma miR-29a/b/c induced apoptosis in GBM cells by silencing CDC42. +other 36727260 hsa-mir-29a Glioblastoma miR-29a/b/c induced apoptosis in GBM cells by silencing CDC42. +genetics_overexpression_promote 36727232 hsa-mir-424 Carcinoma, Hepatocellular 5p mimic can reverse the role of overexpression of KIF23 in promoting the ability of HCC cells to proliferate, migrate and invade (P<0.05). +circulation_biomarker_diagnosis_up 36727070 hsa-mir-155 Carcinoma, Renal Cell 5p in serum was significantly upregulated in RCC patients, and miR +circulation_biomarker_diagnosis_ns 36726971 hsa-mir-126 Inflammation Moreover, we assessed a panel of soluble plasma biomarkers (IL-6/IL-10/GDF-15/IL-15/CXCL9/NfL) and microRNAs (miR-146a-5p, miR +circulation_biomarker_diagnosis_ns 36726971 hsa-mir-146a Inflammation Moreover, we assessed a panel of soluble plasma biomarkers (IL-6/IL-10/GDF-15/IL-15/CXCL9/NfL) and microRNAs (miR-146a-5p, miR +circulation_biomarker_diagnosis_ns 36726971 hsa-mir-21 Inflammation Moreover, we assessed a panel of soluble plasma biomarkers (IL-6/IL-10/GDF-15/IL-15/CXCL9/NfL) and microRNAs (miR-146a-5p, miR +circulation_biomarker_diagnosis_up 36726727 hsa-mir-1287 Microscopic Polyangiitis 5p in the exosomes obtained from MPA plasma. +other 36726727 hsa-mir-1287 Endothelial Inflammatory Injury CONCLUSION: Our study revealed that MPA-exo was involved in the intercellular transfer of miR5p and subsequently promote the development of acute endothelial injury in MPA. +circulation_biomarker_diagnosis_ns 36726153 hsa-mir-744 Sarcopenia Serum concentration of miR-451a, miR +circulation_biomarker_diagnosis_ns 36726153 hsa-mir-155 Sarcopenia Serum concentration of miR-451a, miR +circulation_biomarker_diagnosis_ns 36726153 hsa-mir-93 Frailty 3p serum concentration was reduced, whereas that of miR +circulation_biomarker_diagnosis_ns 36726153 hsa-mir-93 Sarcopenia Serum concentration of miR-451a, miR +circulation_biomarker_diagnosis_ns 36726153 hsa-mir-495 Frailty 3p serum concentration was reduced, whereas that of miR +circulation_biomarker_diagnosis_ns 36726153 hsa-mir-451a Sarcopenia Serum concentration of miR-451a, miR +circulation_biomarker_diagnosis_ns 36726153 hsa-mir-155 Frailty 3p serum concentration was reduced, whereas that of miR +circulation_biomarker_diagnosis_ns 36726153 hsa-mir-495 Sarcopenia Serum concentration of miR-451a, miR +circulation_biomarker_diagnosis_ns 36726153 hsa-mir-451a Frailty CONCLUSION: These results suggest that serum miR-451a should be investigated as a potential biomarker for frailty and show that the VIVIFRAIL multicomponent program modulates circulatory miRNAs expression, at least in older adults. +circRNA target 36726025 hsa-mir-1178 Myocardial Infarction Together, our results reveal that circCEBPZOS attenuates detrimental post-MI remodeling via the miR3p/PDPK1 axis, which facilitates revascularization, ultimately improving the cardiac function. +other 36724751 hsa-mir-142 Mesothelioma CONCLUSION: This study proposed that the miR3p/ITGAV axis is involved in tumor progression in malignant mesothelioma. +circulation_biomarker_diagnosis_up 36724195 hsa-mir-26a Multiple Sclerosis, Chronic Progressive In addition, in serum samples, miR-20a-5p and miR-320b were dysregulated in PPMS against RRMS and OND, miR-26a-5p and miR +circulation_biomarker_diagnosis_up 36724195 hsa-mir-20a Multiple Sclerosis, Chronic Progressive In addition, in serum samples, miR-20a-5p and miR-320b were dysregulated in PPMS against RRMS and OND, miR-26a-5p and miR +circulation_biomarker_diagnosis_up 36724195 hsa-mir-142 Multiple Sclerosis, Chronic Progressive In addition, in serum samples, miR-20a-5p and miR-320b were dysregulated in PPMS against RRMS and OND, miR-26a-5p and miR +circulation_biomarker_diagnosis_up 36724195 hsa-mir-485 Multiple Sclerosis, Chronic Progressive In addition, in serum samples, miR-20a-5p and miR-320b were dysregulated in PPMS against RRMS and OND, miR-26a-5p and miR +circulation_biomarker_diagnosis_up 36724195 hsa-mir-20b Multiple Sclerosis, Chronic Progressive In addition, in serum samples, miR-20a-5p and miR-320b were dysregulated in PPMS against RRMS and OND, miR-26a-5p and miR +exosome 36723877 hsa-mir-20 Reperfusion Injury, Cerebral Ischemia hUC-MSCs-Exos-derived circDLGAP4 reduced cerebrovascular injury by regulating miR-320/KLF5 signaling. +transcription factor target 36723677 hsa-mir-181a Osteoporosis The CTR, NFATC1, MMP-9, CTSK, and TRAP mRNA expression levels were substantially reduced during osteoclast differentiation and bone resorption in the Res treatment group.The results suggest that Res can reduce the RAW 264.7 cell differentiation into osteoclasts and relieve LPS-stimulated osteoporosis, and the underlying mechanism may be associated with the Res-inhibited activity of the TRAF6/TAK1 pathway through the increased miR-181a-5p expression. +other 36723462 hsa-mir-656 Hypertension related dysfunction of endothelial cells in hypertension. +other 36723144 hsa-mir-18b Alzheimer Disease Taking miR-18b-5p and miR3p which are associated with Alzheimer's disease as an example, a FRET sensing system was fabricated for the simultaneous analysis of two miRNAs within one hour at picomolar concentration. +other 36723144 hsa-mir-342 Alzheimer Disease Taking miR-18b-5p and miR3p which are associated with Alzheimer's disease as an example, a FRET sensing system was fabricated for the simultaneous analysis of two miRNAs within one hour at picomolar concentration. +transcription factor target 36723042 hsa-mir-146a Vasculitis In addition, we demonstrated that miR-146a encapsulated liposomes reduced vascular inflammation responses in HAECs and SMCs through inhibition of ICAM-1 expression and decreased monocyte adhesion. Thus, based on these results, miR-146a encapsulated liposomes may be promising for reducing vascular inflammation by targeting its multiple associated mediators. +circulation_biomarker_diagnosis_ns 36723013 hsa-mir-208b Acute Coronary Syndrome In conclusion, our findings indicate that plasma EVs miR-208b-3p and miR3p may serve as promising biomarkers in predicting SCD in patients with ACS, as well as postmortem forensic diagnosis of the cause of death due to ACS. +circulation_biomarker_diagnosis_ns 36723013 hsa-mir-143 Death, Sudden, Cardiac In conclusion, our findings indicate that plasma EVs miR-208b-3p and miR +circulation_biomarker_diagnosis_ns 36723013 hsa-mir-208b Death, Sudden, Cardiac In conclusion, our findings indicate that plasma EVs miR-208b-3p and miR +circulation_biomarker_diagnosis_ns 36723013 hsa-mir-143 Acute Coronary Syndrome In conclusion, our findings indicate that plasma EVs miR-208b-3p and miR3p may serve as promising biomarkers in predicting SCD in patients with ACS, as well as postmortem forensic diagnosis of the cause of death due to ACS. +tissue_expression_ns 36722721 hsa-mir-21 Breast Neoplasms Moreover, MFS-CRISPR assay was evaluated by measuring clinical samples, and the difference of miR-21 expression of breast cancer patients and healthy donors was significant. +exosome 36722453 hsa-mir-374c Carcinoma, Hepatocellular MiR-374c-5p transferred by exosomes derived from bone marrow mesenchymal stem cell (BMSC) suppressed migration, invasion and proliferation of HCC cells. +genetics_overexpression_promote 36722424 hsa-mir-20a Stomach Neoplasms RUNX1-IT1 and miR-20a precursor were predicted to interact with each other, and overexpression of RUNX1-IT1 in GC cells decreased the expression levels of mature miR-20a. +genetics_knock down_promote 36722261 hsa-mir-183 Death 5p, whereas LINC00960 overexpression increases, but its knockdown decreases, the level of Nrdp1 and apoptosis. +lncRNA target 36722214 hsa-mir-493 Diabetic Nephropathies In conclusion, TTN-AS1 exacerbated ECM accumulation via the miR3p/FOXP2 axis during DN development. +circulation_biomarker_prognosis_ns 36721512 hsa-mir-155 Chronic Gastritis CONCLUSION: According to the differential expression patterns of miRNA-155 in serum samples of the infected adult patients, miRNA-155 has the potential to evaluate as chronic gastritis marker. +circulation_biomarker_prognosis_ns 36721512 hsa-mir-155 Inflammation CONCLUSION: According to the differential expression patterns of miRNA-155 in serum samples of the infected adult patients, miRNA-155 has the potential to evaluate as chronic gastritis marker. +exosome 36720469 hsa-mir-378 Ovarian Neoplasms Our study revealed a previously unknown regulatory pathway whereby CAFs-derived exosomes delivered circIFNGR2 and inhibited the malignant progression of OVCA by circIFNGR2/miR-378/ST5 axis. +genetics_knock down_suppress 36720318 hsa-mir-579 Hypoxia-Ischemia, Brain CONCLUSION: This study demonstrated that circ_0007706 knockdown assuaged HIE-induced injury by decreasing TRAF6 expression via targeting miR3p. +other 36720158 hsa-mir-146a Pediatric Cystic Fibrosis Expression of airway miR3p improved the diagnostic value of FEV1% pred and FVC% pred, while peripheral miR-146a improved the predictive model of C-reactive protein and neutrophilia.In silicoanalysis revealed a potential role for selected miRNAs in regulating processes associated with inflammation and tissue remodeling. +other 36720158 hsa-mir-25 Pediatric Cystic Fibrosis Expression of airway miR3p improved the diagnostic value of FEV1% pred and FVC% pred, while peripheral miR-146a improved the predictive model of C-reactive protein and neutrophilia.In silicoanalysis revealed a potential role for selected miRNAs in regulating processes associated with inflammation and tissue remodeling. +other 36719980 hsa-mir-370 Adenocarcinoma of Lung High miR-370 expression was associated with poor overall survival (OS) among lung adenocarcinoma patients (p = 0.045). +genetics_knock down_promote 36719867 hsa-mir-148a Leishmaniasis Increased miR-148a in splenic leukocytes (SL) of dogs with CanL was observed in previous studies, and in silico analysis, identified possible pathways involved in immune response regulation that are affected by this miR. +transcription factor target 36719839 hsa-mir-186 Brain Injuries, Traumatic 5p, through upregulation IGF-1, attenuates the inflammatory factors, oxidative stress and by inhibiting NLRP3/ASC/caspase-1 signal pathway TBI in-vitro model. +other 36719832 hsa-mir-614 Alzheimer Disease 3p, etc. +other 36719832 hsa-mir-2115 Alzheimer Disease 3p, etc. +other 36719832 hsa-mir-193a Alzheimer Disease 3p, etc. +genetics_overexpression_suppress 36719626 hsa-mir-543 Carcinoma, Non-Small-Cell Lung TNRC6A was downregulated and miR-543 was overexpressed in NSCLC cells. +other 36719624 hsa-mir-211 Uterine Cervical Neoplasms CircRNA Circ_0000118 Regulates Malignancy of Cervical Cancer Cells by Regulating miR-211-5p/miR-377-3p/AKT2 Axis. +other 36718820 hsa-mir-326 Glioblastoma In addition, miR-326 was downregulated in glioblastoma cells, which was verified to sponge circRNA-SMO and interact with CEP85. CircRNA-SMO sponges miR-326 to promote glioblastoma proliferation and migration by upregulating CEP85 expression. +genetics_overexpression_promote 36718644 hsa-mir-27a Glioma miR-27a-3p overexpression promotes hypoxia-challenged glioma cell aggressiveness, whereas FTO overexpression partially diminishes the oncogenic effects of miR-27a-3p overexpression. +circulation_biomarker_diagnosis_ns 36718306 hsa-mir-24 Lupus Erythematosus, Systemic CONCLUSION: Our study provided an insight about the role of miR-24 and its target serum YKL-40 protein in the development of SLE-related inflammation and atherosclerosis. +lncRNA target 36717952 hsa-mir-1303 Osteoporosis RESULTS: miR-1303 was lowly expressed, while cochlin (COCH) and KCNMA1-AS1 were highly expressed in the osteoporosis subjects. CONCLUSIONS: Our findings suggest that the KCNMA1-AS1/miR-1303/COCH axis is a promising biomarker and therapeutic target for osteoporosis. +other 36717793 hsa-mir-455 Intracranial Aneurysm METHODS: Expression of the circular RNA circ-ATL1 and microRNA miR-455 was detected in IAs by RT-qPCR. +other 36717790 hsa-mir-125b Asthma, Allergic CONCLUSIONS: miR-125b-5p is significantly over-expressed in asthma, and AK089514-miR-125b-5p-TRAF6 axis play critical role in asthma by modulating macrophage polarization. +other 36717592 hsa-mir-149 Coronary Artery Disease 5p was verified in the stable CAD patients when compared to other groups. +other 36717592 hsa-mir-122 Coronary Artery Disease 5p was verified in the stable CAD patients when compared to other groups. +lncRNA target 36717528 hsa-mir-194 Squamous Cell Carcinoma of Head and Neck 5p and enhance its target gene (KLF7), thereby affecting OSCC development. +circulation_biomarker_diagnosis_down 36717388 hsa-mir-568 Heart Diseases The effects of miR-568 and SMURF2 on CHF rats were evaluated by hematoxylin-eosin staining, Masson's staining, serum index testing, cardiac ultrasound detection, and TUNEL staining assays. +circulation_biomarker_diagnosis_down 36717388 hsa-mir-568 Heart Failure The effects of miR-568 and SMURF2 on CHF rats were evaluated by hematoxylin-eosin staining, Masson's staining, serum index testing, cardiac ultrasound detection, and TUNEL staining assays. +lncRNA target 36717039 hsa-mir-133b Breast Neoplasms In addition, downregulation of NEAT1 decreased the migration and proliferation of BC cells by inhibiting the expression of CXCL12 by reducing the adsorption of miR-133b. Furthermore, inhibition of miR-133b reversed the interference of NEAT1 and CXCL12 in paclitaxel resistance, migration and proliferation of BC cells. +lncRNA target 36716981 hsa-mir-149 Osteoarthritis CONCLUSION: Our study provides evidence that up-regulated miR-149 alleviates OA via inhibition of VCAM-1 and PI3K/AKT pathway, which is helpful for OA treatment. +circulation_biomarker_diagnosis_up 36716518 hsa-mir-146a Rhinitis, Allergic Serum exosome-derived miR-146a-3p seems to be a novel biomarker for predicting the short and long-term efficacies of SLIT in AR patients. +circRNA target 36715861 hsa-mir-186 Retinoblastoma Circ_0119412 was found to be upregulated in RB, and could accelerate the progression of RB via the miR +other 36715854 hsa-mir-24 Leukemia, Myeloid, Acute Taken together, this study emphasized the pro-oncogenic role of CEBPA-AS1 in AML and illustrated its connections with the upstream transcription factor ZFX and the downstream regulative axis miR3p/CTBP2, providing important insights to the cancerogenic process in AML. +epigenetics 36715362 hsa-mir-124-2 Uterine Cervical Neoplasms OBJECTIVE: This study was undertaken to evaluate the performance of FAM19A4 and hsa-mir2 hypermethylation as a triage tool for women who are at risk of developing cervical cancer or high-grade cervical cancer precursor lesions by taking into consideration the cytology report, histology diagnosis, and human papillomavirus (HPV) status. +genetics_knock down_promote 36714464 hsa-mir-155 Diabetic Nephropathies 5p overexpression restored this. +target gene 36714373 hsa-mir-100 Uterine Cervical Neoplasms Hypoxia-induced paclitaxel resistance in cervical cancer modulated by miR-100 targeting of USP15. +other 36714048 hsa-mir-146a Asthma We aimed to investigate the relationship between Treg, miR3p, and miR-146a-5p in relation to asthma phenotypes in search of novel biomarkers of disease severity. +other 36714048 hsa-mir-210 Asthma 3p is a sensitive biomarker and an independent risk factor for BA severity in Egyptian children. +circulation_biomarker_diagnosis_ns 36713778 hsa-mir-128 Parkinson Disease Interestingly, a concomitant decreased expression of miR-128 was observed in the cellular models of PD. Thus, our study depicts the intracellular role of miR-128 in neuronal apoptosis and neurodegeneration and its implications as a biomarker being detectable in the circulating exosomes of PD patient blood. +other 36712879 hsa-mir-20 Heart Failure The above results indicated that the high expression of microRNA-320 and microRNA-204 can be a bad prognostic factor in patients with myocardial infarction, showing that medical data, machine learning and medical care strategies supporting IoMT can play a role in the treatment of myocardial infarction. +other 36712879 hsa-mir-204 Heart Failure The above results indicated that the high expression of microRNA-320 and microRNA-204 can be a bad prognostic factor in patients with myocardial infarction, showing that medical data, machine learning and medical care strategies supporting IoMT can play a role in the treatment of myocardial infarction. +other 36710985 hsa-mir-146a Colorectal Neoplasms We are attempting to determine the clinical relevance of the mechanisms controlling the microRNA (miR-215 and miR-146a) expression and transforming growth factor-beta (TGF-beta)/interleukin-6 (IL-6) in a cross-link axis between obesity and colorectal cancer (CRC). The relative expression of microRNAs (miR-215 and miR-146a) was significantly lower in obese patients with colorectal cancer. +other 36710985 hsa-mir-215 Obesity We are attempting to determine the clinical relevance of the mechanisms controlling the microRNA (miR-215 and miR-146a) expression and transforming growth factor-beta (TGF-beta)/interleukin-6 (IL-6) in a cross-link axis between obesity and colorectal cancer (CRC). The relative expression of microRNAs (miR-215 and miR-146a) was significantly lower in obese patients with colorectal cancer. +other 36710985 hsa-mir-215 Colorectal Neoplasms We are attempting to determine the clinical relevance of the mechanisms controlling the microRNA (miR-215 and miR-146a) expression and transforming growth factor-beta (TGF-beta)/interleukin-6 (IL-6) in a cross-link axis between obesity and colorectal cancer (CRC). The relative expression of microRNAs (miR-215 and miR-146a) was significantly lower in obese patients with colorectal cancer. +other 36710985 hsa-mir-146a Obesity We are attempting to determine the clinical relevance of the mechanisms controlling the microRNA (miR-215 and miR-146a) expression and transforming growth factor-beta (TGF-beta)/interleukin-6 (IL-6) in a cross-link axis between obesity and colorectal cancer (CRC). The relative expression of microRNAs (miR-215 and miR-146a) was significantly lower in obese patients with colorectal cancer. +genetics_knock down_suppress 36709726 hsa-mir-128 Prostatic Neoplasms GLIDR knockdown inhibited the invasion, EMT, and proliferation in PCa cells, and GLIDR was shown to sponge miR +exosome 36709645 hsa-mir-4655 Lung Neoplasms Overall, our results indicated that exosomal miR5p secreted by lung cancer cells after irradiation promoted the proliferation and M2 polarization of macrophages. +other 36709365 hsa-mir-2008 Sjogren's Syndrome Moreover, circ432 is validated to serve as the sponge of miR-2008, a differential expressed miRNA in SUS-diseased sea cucumbers, by Argonaute 2-RNA immunoprecipitation (AGO2-RIP) assay, luciferase reporter assay and RNA fluorescence in situ hybridization (FISH) in vitro. +other 36709121 hsa-mir-204 Carcinoma, Endometrioid 5p may play an important role in human endometrial cancer. +transcription factor target 36709037 hsa-mir-9a Epilepsy The bioinformatic assessment and disease enrichment analysis revealed that miR-9a-5p targets expressed with high confidence in the hippocampus are the most significantly associated with epilepsy. +other 36708978 hsa-mir-642b Myocardial Infarction 3p, hsa_circRNA_0003275, hsa_circRNA_0004494, hsa_circ_0093522, ENST00000467951, ENST00000558177, ACTA2, ANPEP, and CAMP were downregulated. +other 36708978 hsa-mir-760 Myocardial Infarction 3p, hsa_circRNA_0003275, hsa_circRNA_0004494, hsa_circ_0093522, ENST00000467951, ENST00000558177, ACTA2, ANPEP, and CAMP were downregulated. +other 36708978 hsa-mir-424 Myocardial Infarction 3p, hsa_circRNA_0003275, hsa_circRNA_0004494, hsa_circ_0093522, ENST00000467951, ENST00000558177, ACTA2, ANPEP, and CAMP were downregulated. +other 36708978 hsa-mir-21 Myocardial Infarction 3p, hsa_circRNA_0003275, hsa_circRNA_0004494, hsa_circ_0093522, ENST00000467951, ENST00000558177, ACTA2, ANPEP, and CAMP were downregulated. +other 36708662 hsa-mir-218 Child Development Disorders, Pervasive Expression of miR-218 was elevated in patients with autism spectrum disorder (ASD) and schizophrenia. +other 36708662 hsa-mir-218 Heart Septal Defects, Atrial Expression of miR-218 was elevated in patients with autism spectrum disorder (ASD) and schizophrenia. +other 36708662 hsa-mir-218 Mental Disorders These results suggest an underlying mechanism of miR-218 involvement in neuropsychiatric disorders, and the interactions of layer-specific non-coding RNAs and proteins in regulating cortical development. +other 36708662 hsa-mir-218 Schizophrenia Expression of miR-218 was elevated in patients with autism spectrum disorder (ASD) and schizophrenia. +circulation_biomarker_diagnosis_up 36708579 hsa-mir-373 Carcinoma, Hepatocellular This study aimed at assessing the expression profiles of circulating MiR-210 and MiR-373 as potential predictors of response to TACE bridging therapy in a group of Egyptian HCC cases on top of chronic hepatitis-C infection, awaiting liver transplantation. CONCLUSION: Circulating pre-TACE MiR-373 could assist as a noninvasive predictor marker of response to TACE bridging therapy in early HCC patients awaiting liver transplantation. +circulation_biomarker_diagnosis_up 36708579 hsa-mir-210 Carcinoma, Hepatocellular This study aimed at assessing the expression profiles of circulating MiR-210 and MiR-373 as potential predictors of response to TACE bridging therapy in a group of Egyptian HCC cases on top of chronic hepatitis-C infection, awaiting liver transplantation. +lncRNA target 36708573 hsa-mir-379 Endometrial Neoplasms 5p can be used as a diagnostic marker, and ROR1 could be a potential target of miR +lncRNA target 36708560 hsa-mir-145 Urinary Bladder Neoplasms This study aimed to assess the urine and tissue expression levels of miR-200, miR-145 and miR-21 in BC patients o evaluate their potential as noninvasive biomarkers. Conclusion: The results of the present study indicated that miR-200, miR-145 and miR-21 may function as oncogenes and have a potential to serve as an early noninvasive diagnostic biomarkers and therapeutic targets for treatment of BC. +lncRNA target 36708560 hsa-mir-200 Urinary Bladder Neoplasms This study aimed to assess the urine and tissue expression levels of miR-200, miR-145 and miR-21 in BC patients o evaluate their potential as noninvasive biomarkers. Conclusion: The results of the present study indicated that miR-200, miR-145 and miR-21 may function as oncogenes and have a potential to serve as an early noninvasive diagnostic biomarkers and therapeutic targets for treatment of BC. +lncRNA target 36708560 hsa-mir-21 Urinary Bladder Neoplasms This study aimed to assess the urine and tissue expression levels of miR-200, miR-145 and miR-21 in BC patients o evaluate their potential as noninvasive biomarkers. Conclusion: The results of the present study indicated that miR-200, miR-145 and miR-21 may function as oncogenes and have a potential to serve as an early noninvasive diagnostic biomarkers and therapeutic targets for treatment of BC. +transcription factor target 36708044 hsa-mir-143 Glioma In addition, the results indicated that miR3p, which might directly target the 3'UTR of the hexokinase 2 (HK2) gene to regulate its protein expression, was subsequently involved in L1CAM-mediated VM formation by glioma cells. +lncRNA target 36708020 hsa-mir-650 Colorectal Neoplasms RT-qPCR or western blot assays were performed to verify DICER1-AS1, miR-650, and mitogen-activated protein kinase 1 (MAPK1) expression in CRC cells or tissues. CONCLUSION: Our investigations found that upregulation of DICER1-AS1 activates the MAPK/ERK signaling pathway by sponging miR-650 to promote CRC progression, revealing a possible clinically significant biomarker and therapeutic target. +other 36707813 hsa-mir-372 sporatic amyotrophic lateral sclerosis 5p might be potential ceRNA regulatory pathways. +other 36707813 hsa-mir-373 sporatic amyotrophic lateral sclerosis 5p might be potential ceRNA regulatory pathways. +other 36707813 hsa-mir-671 sporatic amyotrophic lateral sclerosis 5p might be potential ceRNA regulatory pathways. +lncRNA target 36707017 hsa-mir-384 Brain Ischemia Based on the above results, we speculated that the molecular mechanism of isoflurane post-conditioning to alleviate ischemic neuronal injury may be related to the regulation of miR5p/ATG5-mediated autophagy. +lncRNA target 36706943 hsa-mir-155 Arthritis, Rheumatoid Further experiments showed that THY1 Ab downregulated the expression of JUNB by the hsa_circ_0094342/miRNA5P/SPI1 axis, inhibited RA angiogenesis and osteoclast differentiation, and relieved RA progression. +lncRNA target 36705783 hsa-let-7d Hypertrophic Scar Fibrosis Consistent with the results in vitro, the miR-let-7d mimics effectively ameliorated hypertrophic scar fibrosis in a rabbit ear hypertrophic scar model. Taken together, our results indicated for the first time that miR-let-7d attenuated hypertrophic scar fibrosis through modulation of iron metabolism by reducing iron uptake through DMT1, which may provide a novel therapeutic strategy for hypertrophic scar. +lncRNA target 36705739 hsa-mir-204 Uveal melanoma As revealed by functional analysis, miR-204 suppressed UM cell invasion and migration. +exosome 36705422 hsa-mir-205 Chronic Periodontitis This research is aimed to investigate the function of exosomal miR +other 36705420 hsa-mir-1207 Intervertebral Disc Degeneration Quantitative real time PCR(qRT-PCR), enzyme-linked immunosorbent assay, and western blotting analyses were performed to evaluate the role of LINC01138, hsa-miR5p, and KIAA0101 during extracellular matrix (ECM) protein degeneration and cellular inflammatory response. +other 36705420 hsa-mir-1207 Osteoarthritis 5p is weakly expressed in OA tissues and cell models. +lncRNA target 36705418 hsa-mir-525 Venous Thrombosis CONCLUSION: LINC00659 played an important role in DVT by regulating the apoptosis of vascular endothelial cells through regulating miR5p/Bax axis. +circulation_biomarker_diagnosis_ns 36705405 hsa-mir-495 Sepsis RESULTS: In HUVECs stimulated with BS patient serum, NEAT1 expression was increased, while miR +lncRNA target 36705303 hsa-mir-574 Acute Lung Injury This research identified that circ_0001498 facilitated sepsis-related ALI progression by targeting miR5p to upregulate SOX6. +lncRNA target 36705303 hsa-mir-574 Sepsis This research identified that circ_0001498 facilitated sepsis-related ALI progression by targeting miR5p to upregulate SOX6. +genetics_overexpression_promote 36704943 hsa-mir-141 Pulmonary Fibrosis 3p and/or adenovirus vectors overexpressing Spred2 one week after BLM treatment. +other 36704851 hsa-mir-151a Colorectal Neoplasms Taken together, the results of the current study revealed a novel molecular mechanism indicating that the miR151a5p/AGMAT axis could serve a crucial role in the regulation of CRC and could therefore be considered as a potential therapeutic strategy for CRC. +transcription factor target 36704832 hsa-mir-155 Carcinoma, Hepatocellular MiR-155 accelerates HCC cell proliferation, migration and invasion by targeting SHIP1 expression and inducing macrophage M2 polarization. +lncRNA target 36704357 hsa-mir-200a Endometrial Neoplasms The upregulated hsa-mir-200a-b is associated with the decreased expression of the PTCH1, CCND2, PDGFRA, FOSB and ABL1 genes in endometrial cancer tissue while hsa-mir-429 is correlated with the decreased expression of the ALDH1A1 gene, besides some antibodies, PROTACs and inhibitory molecules. In conclusion, this study identified key miRNAs (hsa-mir-200a, hsa-mir-429) and target genes ALDH1A1, ABL1 and CCND2 as potential biomarkers for metastatic endometrial cancers from large-scale gene expression data using systems biology approaches. +lncRNA target 36704357 hsa-mir-429 Endometrial Neoplasms The upregulated hsa-mir-200a-b is associated with the decreased expression of the PTCH1, CCND2, PDGFRA, FOSB and ABL1 genes in endometrial cancer tissue while hsa-mir-429 is correlated with the decreased expression of the ALDH1A1 gene, besides some antibodies, PROTACs and inhibitory molecules. In conclusion, this study identified key miRNAs (hsa-mir-200a, hsa-mir-429) and target genes ALDH1A1, ABL1 and CCND2 as potential biomarkers for metastatic endometrial cancers from large-scale gene expression data using systems biology approaches. +circulation_biomarker_prognosis_up 36704329 hsa-mir-5 Migraine Disorders The combination of serum levels of exosomal has-miR +circulation_biomarker_prognosis_up 36704329 hsa-mir-145 Migraine Disorders The combination of serum levels of exosomal has-miR +other 36704329 hsa-mir-378a Migraine Disorders Among them, has-miR-378a-5p was positively correlated with time unable to work, study, or do housework due to migraine (p < 0.05), whereas has-miR3p was negatively correlated with the restrictive subscale of the migraine-specific quality of life questionnaire (MSQ) (p < 0.05). +circulation_biomarker_prognosis_up 36704329 hsa-mir-369 Migraine Disorders The combination of serum levels of exosomal has-miR +other 36704329 hsa-mir-605 Migraine Disorders Among them, has-miR-378a-5p was positively correlated with time unable to work, study, or do housework due to migraine (p < 0.05), whereas has-miR3p was negatively correlated with the restrictive subscale of the migraine-specific quality of life questionnaire (MSQ) (p < 0.05). +other 36703917 hsa-mir-497 Squamous Cell Carcinoma of Head and Neck Computational analysis and functional predictions identified protein kinase c alpha (PRKCA), miR-6087, miR-449b-5p, miR-3656, miR-326, miR-146b-5p, and miR5p as potential salivary indicators of OSCC. +other 36703917 hsa-mir-449b Squamous Cell Carcinoma of Head and Neck Computational analysis and functional predictions identified protein kinase c alpha (PRKCA), miR-6087, miR-449b-5p, miR-3656, miR-326, miR-146b-5p, and miR5p as potential salivary indicators of OSCC. +other 36703917 hsa-mir-6087 Squamous Cell Carcinoma of Head and Neck Computational analysis and functional predictions identified protein kinase c alpha (PRKCA), miR-6087, miR-449b-5p, miR-3656, miR-326, miR-146b-5p, and miR5p as potential salivary indicators of OSCC. +genetics_overexpression_promote 36703756 hsa-mir-199b Spinal Cord Injuries Moreover, miR-199b-5p overexpression polarized M1 macrophage into M2 phenotype and promoted neural regeneration in SCI. +other 36703740 hsa-mir-9 Ovarian Neoplasms Curcumin enhances the anti-cancer efficacy of paclitaxel in ovarian cancer by regulating the miR-9-5p/BRCA1 axis. +other 36703641 hsa-mir-567 Carotid Artery Diseases hsa-miR-567 and hsa-miR5p may be significantly associated with CAS and VaD. +other 36703641 hsa-mir-4652 Carotid Artery Diseases hsa-miR-567 and hsa-miR5p may be significantly associated with CAS and VaD. +other 36703641 hsa-mir-4652 Dementia, Vascular hsa-miR-567 and hsa-miR5p may be significantly associated with CAS and VaD. +other 36703641 hsa-mir-567 Dementia, Vascular hsa-miR-567 and hsa-miR5p may be significantly associated with CAS and VaD. +genetics_knock down_suppress 36702852 hsa-mir-1275 Stomach Neoplasms Overexpression and knockdown of miR-1275 in vitro could indirectly modulate the above lipid signalling by targeting FAAH, thereby affecting GC progression. Our study indicates that deregulated FAAH is a key lipid signal and the miR-1275/FAAH/AEA/LPA axis can serve as a diagnostic biomarker for GC or as a target for therapy development. +other 36702759 hsa-mir-501 Diabetes Mellitus, Type 2 Expression analysis of the PDGF-miR-501 signaling pathway could represent a powerful tool to classify patients in clinical trials that aim to improve muscle health and glucose homeostasis in diabetic patients. +other 36702354 hsa-mir-221 Inflammation Previously, we found miR5p was aberrant and associated with the inflammation of RT induction. +transcription factor target 36701994 hsa-mir-34a Esophageal Squamous Cell Carcinoma RESULTS: LJZD significantly interfered with ILinduced activation of the miR-34a/STAT3/IL-6R feedback loop in ESCC by restoring the expression of the tumour suppressor miR-34a, and inhibited the proliferation of EC109 oesophageal cancer cells in a dose-dependant manner. +genetics_overexpression_promote 36701370 hsa-mir-130b Leiomyosarcoma Conversely, miR-130b-overexpressing LMS cells exhibited Rho-independent invasion, accompanied by down-regulation of Rho-pathway effectors. +genetics_knock down_suppress 36701095 hsa-mir-375 Breast Neoplasms Knockdown of miR-375 expression in BC cells reduces cell proliferation, migration, and invasion by inverse correlation expression of HOXA5. +transcription factor target 36700779 hsa-mir-205 Atherosclerosis CONCLUSION: ICA can alleviate AS and inhibit the proliferation and migration of HAVSMCs induced by ox-LDL, potentially mediated by the upregulation of miR5p. +circulation_biomarker_diagnosis_up 36700764 hsa-mir-193b Elliptocytosis 2 High-throughput sequencing revealed that miR-193b-3p was markedly up-regulated in plasma exosomes of non-rejection LT patients. +genetics_knock down_promote 36700761 hsa-mir-141 Incontinentia Pigmenti CONCLUSION: Circ_0044411 knockdown promoted cell viability and proliferation, inhibited inflammatory response and apoptosis by regulating miR3p/CCL16 axis, indicating that circ_0044411 might be a potential therapeutic target for IP. +lncRNA target 36700475 hsa-mir-361 Stomach Neoplasms MUC13, which is targeted by miR +genetics_knock down_promote 36700300 hsa-mir-125a Carcinoma, Hepatocellular Overexpression of miR-125a-5p enhanced the repressive effects of CYTOR knockdown on HCC cells, and knockdown of HAX-1 enhanced the inhibitory effects of miR-125a-5p mimics on HCC cells. +lncRNA target 36700043 hsa-mir-10b Glioma The effect is mediated by the secreted miR-10b targets phosphoglycerate kinase 1 (PGK1) and insulin-like growth factor binding protein 2 (IGFBP2) that block cell-cycle progression and induce glioma cell death. +lncRNA target 36700022 hsa-mir-20a Osteoarthritis And then we analysed miRNA-320a-targeted OA genes via KEGG, GO enrichment and PPI Network. +lncRNA target 36699616 hsa-mir-361 Carcinoma, Hepatocellular Mechanistically, BBOX1-AS1 enhanced the stability of PHF8 mRNA by targeting the PHF8 inhibitor miR +genetics_overexpression_promote 36699282 hsa-mir-1294 Esophageal Squamous Cell Carcinoma PBX3 overexpression could reverse the suppressive roles of miR-1294 mimics on ESCC proliferation and invasion. +other 36698420 hsa-mir-194 Carcinoma, Hepatocellular 3p. +genetics_overexpression_promote 36698227 hsa-mir-128 Colonic Neoplasms CONCLUSION: LncRNA PCAT1 was overexpressed in CC cells and facilitated CC cell proliferation and invasion via inhibition of miR +transcription factor target 36698180 hsa-mir-132 Diabetes Mellitus, Type 2 We identified Kruppel-like factor 7 (KLF7) as a target of miR +target gene 36697993 hsa-mir-103a Lung Neoplasms CYTOR Promotes Proliferation of Lung Cancer Cell by Targeting miR-103a-3p to Upregulate HMGB1. +other 36697494 hsa-mir-21 Infertility, Male This study found that miR-21 is expressed less in women with female factor infertility, and human oocytes' development is crucially affected by the expression of miR-21. +other 36697494 hsa-mir-21 Infertility, Female This study found that miR-21 is expressed less in women with female factor infertility, and human oocytes' development is crucially affected by the expression of miR-21. +circulation_biomarker_diagnosis_up 36697494 hsa-mir-21 Cataract, Congenital Zonular, with Sutural Opacities MiR-21 abundance was higher in FF and CCs samples than in serum. +exosome 36697316 hsa-mir-92a Adenomyosis 3p, hsa-miR-26a-5p, hsa-miR-92a-3p, hsa-miR-92b-3p, hsa-miR-200c-3p and hsa-miR-423a-5p, related to adenomyosis pathogenesis and implantation failure. +exosome 36697316 hsa-mir-21 Adenomyosis 3p, hsa-miR-26a-5p, hsa-miR-92a-3p, hsa-miR-92b-3p, hsa-miR-200c-3p and hsa-miR-423a-5p, related to adenomyosis pathogenesis and implantation failure. +exosome 36697316 hsa-mir-200c Adenomyosis 3p, hsa-miR-26a-5p, hsa-miR-92a-3p, hsa-miR-92b-3p, hsa-miR-200c-3p and hsa-miR-423a-5p, related to adenomyosis pathogenesis and implantation failure. +exosome 36697316 hsa-mir-92b Adenomyosis 3p, hsa-miR-26a-5p, hsa-miR-92a-3p, hsa-miR-92b-3p, hsa-miR-200c-3p and hsa-miR-423a-5p, related to adenomyosis pathogenesis and implantation failure. +exosome 36697316 hsa-mir-24 Adenomyosis 3p, hsa-miR-26a-5p, hsa-miR-92a-3p, hsa-miR-92b-3p, hsa-miR-200c-3p and hsa-miR-423a-5p, related to adenomyosis pathogenesis and implantation failure. +exosome 36697316 hsa-mir-423a Adenomyosis 3p, hsa-miR-26a-5p, hsa-miR-92a-3p, hsa-miR-92b-3p, hsa-miR-200c-3p and hsa-miR-423a-5p, related to adenomyosis pathogenesis and implantation failure. +exosome 36697316 hsa-mir-222 Adenomyosis 3p and hsa-miR-423a-5p were associated with preeclampsia and miscarriage. +exosome 36697316 hsa-mir-26a Adenomyosis 3p, hsa-miR-26a-5p, hsa-miR-92a-3p, hsa-miR-92b-3p, hsa-miR-200c-3p and hsa-miR-423a-5p, related to adenomyosis pathogenesis and implantation failure. +lncRNA target 36697118 hsa-mir-944 Squamous Cell Carcinoma of Head and Neck Furthermore, FUT8-AS1 enhanced the expression of transcription factor 4 (TCF4) via sponging miR-944 and recruiting fused in sarcoma (FUS), thus affecting OSCC cell biological behaviors via modulation on Wnt/beta-catenin signaling activity. To conclude, TCF4-mediated FUT8-AS1 could exacerbate OSCC cell malignant behaviors and facilitate tumor growth via modulation on miR-944/FUS/TCF4. +circulation_biomarker_diagnosis_ns 36697090 hsa-mir-221 Early-Stage Malignant Melanoma Our study showed that preoperative plasma levels of miR-99a, miR-221, miR-320, miR-494, miR-1908 and miR-4487 were associated with disease-free interval and overall survival of patients with early-stage melanoma. +circulation_biomarker_diagnosis_ns 36697090 hsa-mir-4487 Early-Stage Malignant Melanoma Our study showed that preoperative plasma levels of miR-99a, miR-221, miR-320, miR-494, miR-1908 and miR-4487 were associated with disease-free interval and overall survival of patients with early-stage melanoma. +circulation_biomarker_diagnosis_ns 36697090 hsa-mir-20 Early-Stage Malignant Melanoma Our study showed that preoperative plasma levels of miR-99a, miR-221, miR-320, miR-494, miR-1908 and miR-4487 were associated with disease-free interval and overall survival of patients with early-stage melanoma. +circulation_biomarker_diagnosis_ns 36697090 hsa-mir-1908 Early-Stage Malignant Melanoma Our study showed that preoperative plasma levels of miR-99a, miR-221, miR-320, miR-494, miR-1908 and miR-4487 were associated with disease-free interval and overall survival of patients with early-stage melanoma. +circulation_biomarker_diagnosis_ns 36697090 hsa-mir-99a Early-Stage Malignant Melanoma Our study showed that preoperative plasma levels of miR-99a, miR-221, miR-320, miR-494, miR-1908 and miR-4487 were associated with disease-free interval and overall survival of patients with early-stage melanoma. +circulation_biomarker_diagnosis_ns 36697090 hsa-mir-494 Early-Stage Malignant Melanoma Our study showed that preoperative plasma levels of miR-99a, miR-221, miR-320, miR-494, miR-1908 and miR-4487 were associated with disease-free interval and overall survival of patients with early-stage melanoma. +lncRNA target 36696967 hsa-mir-1228 Carcinoma, Non-Small-Cell Lung Our findings elucidate the potential molecular mechanisms underlying the ability of SNH to suppress NSCLC growth through activation of pyroptosis via the TCONS-14036/miR5p/PRKCDBP pathway. +circulation_biomarker_diagnosis_up 36696711 hsa-mir-142 Rhinitis, Allergic CONCLUSION: The expression levels of serum miR +circulation_biomarker_diagnosis_up 36696711 hsa-mir-155 Rhinitis, Allergic CONCLUSION: The expression levels of serum miR +lncRNA target 36696241 hsa-mir-498 Colorectal Neoplasms A study of the molecular mechanism suggests that a circ-FADS2/miR-498/S100A16/AKT signaling cascade may be a potential therapeutic target for the treatment of CRC. +genetics_knock down_suppress 36696015 hsa-mir-210 Myocardial Infarction Knockdown of miR3p in N-EVs significantly impaired its ability to protect the heart after myocardial infarction. +genetics_overexpression_suppress 36695693 hsa-mir-449a Aortic Valve Insufficiency Overexpression of miR-449a not only inhibited the M1-polarization of macrophages in vitro but also improved the AR of transplant in vivo. +genetics_knock down_promote 36695641 hsa-mir-122 Triple Negative Breast Neoplasms The expression of hub genes distinguished TNBC tumors with gain or loss of miR-122 from normal breast tissues. +transcription factor target 36695612 hsa-mir-20a Iris Diseases Functionally, the miR-20a-5p mimic attenuated IRI and postischemic renal fibrosis, whereas the miR-20a-5p inhibitor delivery aggravated IRI and fibrosis. +transcription factor target 36695612 hsa-mir-20a Fibrosis Functionally, the miR-20a-5p mimic attenuated IRI and postischemic renal fibrosis, whereas the miR-20a-5p inhibitor delivery aggravated IRI and fibrosis. +transcription factor target 36695612 hsa-mir-20a Kidney Failure, Chronic Functionally, the miR-20a-5p mimic attenuated IRI and postischemic renal fibrosis, whereas the miR-20a-5p inhibitor delivery aggravated IRI and fibrosis. +genetics_knock down_suppress 36695612 hsa-mir-20a Kidney Diseases Functionally, the miR-20a-5p mimic attenuated IRI and postischemic renal fibrosis, whereas the miR-20a-5p inhibitor delivery aggravated IRI and fibrosis. Importantly, delivery of the miR-20a-5p mimic or inhibitor in the donor kidneys attenuated or aggravated renal loss and structural damage in cold storage transplantation injury. +other 36695578 hsa-mir-335 Hepatitis E We found that miR-194, miR-335, and miR-221 can discriminate between asymptomatic HEV infections and those developing acute symptoms, whereas miR-335 correctly classifies AHE and CHE patients. +other 36695578 hsa-mir-27a Hepatitis E AHE patients showed significantly higher levels of miR-122 and miR-194 and lower levels of miR-221, miR-27a, and miR-335 than HEV BDs. +other 36695578 hsa-mir-221 Hepatitis E We found that miR-194, miR-335, and miR-221 can discriminate between asymptomatic HEV infections and those developing acute symptoms, whereas miR-335 correctly classifies AHE and CHE patients. +other 36695578 hsa-mir-122 Hepatitis E AHE patients showed significantly higher levels of miR-122 and miR-194 and lower levels of miR-221, miR-27a, and miR-335 than HEV BDs. +other 36695578 hsa-mir-194 Hepatitis E We found that miR-194, miR-335, and miR-221 can discriminate between asymptomatic HEV infections and those developing acute symptoms, whereas miR-335 correctly classifies AHE and CHE patients. +exosome 36695327 hsa-mir-615 Diabetic Nephropathies The combined diagnosis of urinary exosomal miRNA +other 36695179 hsa-mir-629 Azoospermia 5p (p = 0.03 and 0.06, respectively). +lncRNA target 36695093 hsa-mir-197 Carcinoma, Hepatocellular 3p/GNA14 (lncRNA/miRNA/mRNA) ceRNA axis to further explain the mechanism of sex-related prognosis in the development of HCC and to provide new insights into candidate biomarkers for targeted therapies. +circRNA target 36694911 hsa-mir-377 Carcinoma, Non-Small-Cell Lung Furthermore, miR-377 inhibitor reversed the inhibitory ability of circ_0070659 silencing on malignant biological behavior of NSCLC cells. Our study revealed a novel signaling pathway that circ_0070659/miR-377/RAB3C axis regulates tumor progression, and it may become a new therapeutic target for NSCLC. +lncRNA target 36694626 hsa-mir-766 Colorectal Neoplasms Besides that, inhibition of miR-766 reduced CRC cell growth and sensitized cells to radiotherapy, and these effects mediated by miR-766 inhibitor were rescued by the silencing of SMAD4. +genetics_overexpression_promote 36694453 hsa-mir-326 Adenocarcinoma of Lung Moreover, LINC01270 was found inhibiting miR-326 and thereby overexpressing the abundance of LARP1 to promote LUAD development via PI3K/AKT pathway. All of these findings demonstrate thatLINC01270 is a tumor promotor in LUAD via enhancing LARP1 expressed by sponging miR-326 to facilitate the development of LUAD. +transcription factor target 36694425 hsa-mir-34a Osteomyelitis EHP might be a potential adjuvant herbal remedy for the treatment of bone nonunion, and miRNA-34a-5p is a novel target for controlling bone and metabolic diseases. +other 36694220 hsa-mir-206 Thyroid Neoplasms RESULTS: Compared with the patients with benign thyroid nodules, the expression level of miR-206 in fine-needle aspiration cytology of thyroid cancer patients decreased significantly and the expression level of CCND2 increased significantly. CONCLUSIONS: miR-206 and CCND2 may become new biomarkers for clinical diagnosis of thyroid cancer based on the fine-needle aspiration cytology of thyroid nodules. +lncRNA target 36693615 hsa-mir-448 Heart Failure mediated upregulation in ischemia, suggesting a new mechanism for the antiarrhythmic effect of miR-448 inhibition. +lncRNA target 36693551 hsa-mir-155 Sepsis In conclusion, our findings indicate that GAS5 suppresses inflammatory responses by modulating the miR5p/SIRT1/HMGB1 axis in sepsis, providing a novel therapeutic target for inflammation in sepsis. +circRNA target 36691537 hsa-mir-665 Triple Negative Breast Neoplasms Collectively, the regulatory network circAR-E2E4-miRSTAT3 axis we constructed was associated with TNBC progression, providing a promising diagnostic, prognostic, and therapeutic target in future treatment for TNBC. +other 36691432 hsa-mir-181a Colorectal Neoplasms Downregulation of LncRNA SNHG7 Sensitizes Colorectal Cancer Cells to Resist Anlotinib by Regulating miR-181a-5p/GATA6. +genetics_overexpression_suppress 36691322 hsa-mir-1287 Carcinoma, Non-Small-Cell Lung 5p interacted with RBBP4, and RBBP4 overexpression partly reversed the inhibitory effect of miR +other 36691005 hsa-mir-17 Autistic Disorder 5p, as signature regulators for autism using important genes and mRNA-miRNA network. +other 36691005 hsa-mir-92a-1 Autistic Disorder 5p, as signature regulators for autism using important genes and mRNA-miRNA network. +other 36691005 hsa-mir-18a Autistic Disorder 5p, as signature regulators for autism using important genes and mRNA-miRNA network. +other 36691005 hsa-mir-181a Autistic Disorder 5p, as signature regulators for autism using important genes and mRNA-miRNA network. +other 36691005 hsa-mir-155 Autistic Disorder 5p, as signature regulators for autism using important genes and mRNA-miRNA network. +transcription factor target 36690096 hsa-mir-221 Neurodevelopmental Disorders Collectively, our data suggest fluoride impairs mitochondrial translation by dysregulating the miR3p/c-Fos/RMND1 axis to trigger mitochondrial dysfunction, leading to neuronal death and neurodevelopment defects. +other 36689923 hsa-mir-185 Asthma 3p/ZNFX1, may exist in asthma. +other 36689317 hsa-mir-375 Neuropathic Low Back Pain We found that five out of 18 miRNAs repressed TRPV1 expression, and the levels of miR-375 and miR-455 were negatively correlated with the protein level of TRPV1 in patients with NP. +other 36689317 hsa-mir-455 Neuropathic Low Back Pain We found that five out of 18 miRNAs repressed TRPV1 expression, and the levels of miR-375 and miR-455 were negatively correlated with the protein level of TRPV1 in patients with NP. +circRNA target 36689155 hsa-mir-146b Intervertebral Disc Degeneration Hsa_circ_0040039 may participate in IDD development by mediating the repair and regeneration of NPs through upregulation MMP2 and PCNA mediated by miR-146b-3p. +circulation_biomarker_diagnosis_up 36689014 hsa-mir-15a Myocardial Infarction This study aimed to investigate the effects of co-treatment of aerobic-resistance training (ART), vitamin D(3) (VD(3)) on cardiovascular function considering the involvement of microRNA-15a and microRNA-146a, vascular endothelial growth factor (VEGF), phosphatidylinositol-3 kinase (PI3K), and endothelial nitric oxide synthase (eNOS) after myocardial infarction (MI) in rats. Furthermore, the levels of circulating microRNA-15a and microRNA-146a were significantly decreased in these groups compared to MI rats that were together with a significant upregulation of cardiac VEGF, PI3K, and eNOS expression. +circulation_biomarker_diagnosis_up 36689014 hsa-mir-146a Myocardial Infarction This study aimed to investigate the effects of co-treatment of aerobic-resistance training (ART), vitamin D(3) (VD(3)) on cardiovascular function considering the involvement of microRNA-15a and microRNA-146a, vascular endothelial growth factor (VEGF), phosphatidylinositol-3 kinase (PI3K), and endothelial nitric oxide synthase (eNOS) after myocardial infarction (MI) in rats. Furthermore, the levels of circulating microRNA-15a and microRNA-146a were significantly decreased in these groups compared to MI rats that were together with a significant upregulation of cardiac VEGF, PI3K, and eNOS expression. +lncRNA target 36688989 hsa-mir-516b Kidney Calculi Patients with kidneys stones showed down-regulated LINC01197 and SIRT3 expression, and up-regulated miR-516b-5p expression. In conclusion, the present study revealed that lncRNA LINC01197 inhibited CaOx-induced kidney stones formation by regulating the miR-516b-5p/SIRT3/FOXO1 signaling pathway. +other 36688191 hsa-mir-155 COVID-19 CONCLUSION: The expression of miR-155 increased in patients with DLBCL and/or COVID-19. +other 36688110 hsa-mir-4647 Colorectal Neoplasms miR-4647 is predicted in silico to bind to the MUC13 gene and was analyzed by RT-qPCR in 187 tumors and their adjacent non-malignant mucosa of patients with CRC. +lncRNA target 36686977 hsa-mir-582 Nasopharyngeal Carcinoma In brief, the results of the research clarified circSMARCA5 modulated NPC cells' vital movement via the miR +transcription factor target 36686218 hsa-mir-372 Pre-Eclampsia 3p may act as a factor to cause PE and may also be a potential novel therapeutic target for PE. +circulation_biomarker_diagnosis_up 36685889 hsa-mir-628 Alzheimer Disease We previously reported that plasma miR3p was up-regulated in AD with severe ACD, but not in severe AD without severe ACD or in our healthy controls. +other 36685889 hsa-mir-130a Alzheimer Disease Results: Quantitative miRNA PCR assays showed that hsa-let-7a-5p, hsa-let-7days-3p, hsa-let-7e-5p, and hsa-miR-151a-5p were significantly up-regulated in both AD-ACD (+) and AD-ACD (-) as were hsa-miR-130a-3p, hsa-miR-151a-3p, has-miR-27b-3p, and hsa-miR-146a-5p in AD-ACD (+) but not in AD-ACD (-) . +other 36685889 hsa-mir-27b Alzheimer Disease Results: Quantitative miRNA PCR assays showed that hsa-let-7a-5p, hsa-let-7days-3p, hsa-let-7e-5p, and hsa-miR-151a-5p were significantly up-regulated in both AD-ACD (+) and AD-ACD (-) as were hsa-miR-130a-3p, hsa-miR-151a-3p, has-miR-27b-3p, and hsa-miR-146a-5p in AD-ACD (+) but not in AD-ACD (-) . +other 36685889 hsa-mir-151a Alzheimer Disease Results: Quantitative miRNA PCR assays showed that hsa-let-7a-5p, hsa-let-7days-3p, hsa-let-7e-5p, and hsa-miR-151a-5p were significantly up-regulated in both AD-ACD (+) and AD-ACD (-) as were hsa-miR-130a-3p, hsa-miR-151a-3p, has-miR-27b-3p, and hsa-miR-146a-5p in AD-ACD (+) but not in AD-ACD (-) . +circulation_biomarker_diagnosis_ns 36685889 hsa-let-7a Keratoconjunctivitis Sicca It is possible that in an allergic disease such as atopic keratoconjunctivitis and/or dermatitis, innate immune responses might be positively regulated by hsa-let-7a-5p in the plasma. +other 36685889 hsa-mir-146a Alzheimer Disease Results: Quantitative miRNA PCR assays showed that hsa-let-7a-5p, hsa-let-7days-3p, hsa-let-7e-5p, and hsa-miR-151a-5p were significantly up-regulated in both AD-ACD (+) and AD-ACD (-) as were hsa-miR-130a-3p, hsa-miR-151a-3p, has-miR-27b-3p, and hsa-miR-146a-5p in AD-ACD (+) but not in AD-ACD (-) . +other 36685889 hsa-let-7e Alzheimer Disease Results: Quantitative miRNA PCR assays showed that hsa-let-7a-5p, hsa-let-7days-3p, hsa-let-7e-5p, and hsa-miR-151a-5p were significantly up-regulated in both AD-ACD (+) and AD-ACD (-) as were hsa-miR-130a-3p, hsa-miR-151a-3p, has-miR-27b-3p, and hsa-miR-146a-5p in AD-ACD (+) but not in AD-ACD (-) . +other 36685889 hsa-let-7a Alzheimer Disease Results: Quantitative miRNA PCR assays showed that hsa-let-7a-5p, hsa-let-7days-3p, hsa-let-7e-5p, and hsa-miR-151a-5p were significantly up-regulated in both AD-ACD (+) and AD-ACD (-) as were hsa-miR-130a-3p, hsa-miR-151a-3p, has-miR-27b-3p, and hsa-miR-146a-5p in AD-ACD (+) but not in AD-ACD (-) . Conclusion: Hsa-let-7a-5p, which was significantly up-regulated in AD-ACD (+) and AD-ACD (-) , could positively regulate the important innate immune-related genes such as TLR3, RIG-I, and MDA5. +circulation_biomarker_diagnosis_ns 36685889 hsa-let-7a Hypersensitivity It is possible that in an allergic disease such as atopic keratoconjunctivitis and/or dermatitis, innate immune responses might be positively regulated by hsa-let-7a-5p in the plasma. +other 36685889 hsa-let-7d Alzheimer Disease Results: Quantitative miRNA PCR assays showed that hsa-let-7a-5p, hsa-let-7days-3p, hsa-let-7e-5p, and hsa-miR-151a-5p were significantly up-regulated in both AD-ACD (+) and AD-ACD (-) as were hsa-miR-130a-3p, hsa-miR-151a-3p, has-miR-27b-3p, and hsa-miR-146a-5p in AD-ACD (+) but not in AD-ACD (-) . +circulation_biomarker_diagnosis_ns 36685889 hsa-let-7a Dermatitis It is possible that in an allergic disease such as atopic keratoconjunctivitis and/or dermatitis, innate immune responses might be positively regulated by hsa-let-7a-5p in the plasma. +other 36685833 hsa-mir-24 pancreatic adenocarcinoma Correlation analysis suggested that the long non-coding RNA (lncRNA) AL049555.1 and the microRNA (miRNA) hsa-miR5p were involved in the expression of RNF169, composing a potential regulatory axis to control the progression of PAAD. +other 36685826 hsa-mir-214 Ischemic Stroke "The functional enrichment of 282 DEGs between the two clusters was mainly concentrated in the ""regulation of apoptotic signaling pathway,"" ""cellular response to DNA damage stimulus,"" ""adaptive immune system,"" and ""pyroptosis."" The miRLTF-FOXJ1 axis may be a key regulatory pathway for IS." +circulation_biomarker_diagnosis_ns 36685382 hsa-mir-122 Acquired Immunodeficiency Syndrome In a previous recent work, we recognized three plasma circulating microRNAs (miRNAs)-miR +circulation_biomarker_diagnosis_ns 36685382 hsa-mir-192 Acquired Immunodeficiency Syndrome In a previous recent work, we recognized three plasma circulating microRNAs (miRNAs)-miR +circulation_biomarker_diagnosis_ns 36685382 hsa-mir-100 Acquired Immunodeficiency Syndrome In a previous recent work, we recognized three plasma circulating microRNAs (miRNAs)-miR +circulation_biomarker_diagnosis_down 36684655 hsa-mir-143 Diabetes, Gestational 3p levels are downregulated in the peripheral blood of patients with GDM. +other 36684425 hsa-mir-24 Osteoarthritis Each miR-23a/b, miR-24, and miR-27a/b is thought to function coordinately and complementary to each other, and the role of each miR-23a/b, miR-24, and miR-27a/b in OA pathogenesis is still controversial. Together, miR-23a/b clusters, composed of miR-23a/b, miR-24, miR-27a/b do not significantly contribute to OA pathogenesis. +other 36684425 hsa-mir-23-2 Osteoarthritis Each miR-23a/b, miR-24, and miR-27a/b is thought to function coordinately and complementary to each other, and the role of each miR-23a/b, miR-24, and miR-27a/b in OA pathogenesis is still controversial. Together, miR-23a/b clusters, composed of miR-23a/b, miR-24, miR-27a/b do not significantly contribute to OA pathogenesis. +other 36684425 hsa-mir-27a Osteoarthritis Each miR-23a/b, miR-24, and miR-27a/b is thought to function coordinately and complementary to each other, and the role of each miR-23a/b, miR-24, and miR-27a/b in OA pathogenesis is still controversial. Together, miR-23a/b clusters, composed of miR-23a/b, miR-24, miR-27a/b do not significantly contribute to OA pathogenesis. +exosome 36684253 hsa-mir-3120 Tuberculosis Additionally, we hypothesized that tumor cells affected natural killer cells and promoted the generation of PE in LUAD via the exosomal hsa-miR5p-PRF1 axis. +exosome 36684253 hsa-mir-3120 Adenocarcinoma of Lung Additionally, we hypothesized that tumor cells affected natural killer cells and promoted the generation of PE in LUAD via the exosomal hsa-miR5p-PRF1 axis. +other 36684045 hsa-mir-499 Carcinoma, Hepatocellular CONCLUSION: In summary, this meta-analysis highlights that rs3746444 in the miR-499 gene is involved in the occurrence of HCC, especially in Asian individuals. +target gene 36684043 hsa-mir-590 Colorectal Neoplasms Hsa_circ_0001658 accelerates the progression of colorectal cancer through miR-590-5p/METTL3 regulatory axis. +circulation_biomarker_diagnosis_ns 36683505 hsa-mir-637 Angelman Syndrome RESULTS: The expression of circ_0033596 and GRB2 was significantly increased, while miR-637 was decreased in the blood of AS patients and ox-LDL-induced HUVECs compared with controls. CONCLUSION: Circ_0033596 depletion protected against ox-LDL-induced HUVEC injury by miR-637/GRB2 pathway, providing a therapeutic target for AS. +circRNA target 36683504 hsa-mir-1197 Angelman Syndrome CONCLUSION: Circ_0090231 might protect against ox-LDL-mediated HUVEC injury via the miR-1197/RAB22A axis, which provides a therapeutic strategy for endothelial cell damage of AS. +other 36682830 hsa-mir-138 Osteoporosis Thus, the miR5p/SIRT1 pathway should be considered for preventative treatment of disuse osteoporosis. +epigenetics 36682704 hsa-mir-188 Leukemia, Myeloid, Acute 5p promoter hydroxymethylation, and miR +circulation_biomarker_diagnosis_up 36682281 hsa-mir-130 Gallbladder Neoplasms The expression pattern of serum miR-1, miR130, and miR-146 gradually decreased from normal control (NC) to CC to GBC, while miR-21 and miR-182 gradually increased from NC to CC to GBC. +circulation_biomarker_diagnosis_up 36682281 hsa-mir-21 Gallbladder Neoplasms The expression pattern of serum miR-1, miR130, and miR-146 gradually decreased from normal control (NC) to CC to GBC, while miR-21 and miR-182 gradually increased from NC to CC to GBC. +circulation_biomarker_diagnosis_up 36682281 hsa-mir-146 Gallbladder Neoplasms The expression pattern of serum miR-1, miR130, and miR-146 gradually decreased from normal control (NC) to CC to GBC, while miR-21 and miR-182 gradually increased from NC to CC to GBC. +circulation_biomarker_diagnosis_up 36682281 hsa-mir-182 Gallbladder Neoplasms The expression pattern of serum miR-1, miR130, and miR-146 gradually decreased from normal control (NC) to CC to GBC, while miR-21 and miR-182 gradually increased from NC to CC to GBC. +circulation_biomarker_diagnosis_up 36682281 hsa-mir-1 Gallbladder Neoplasms The expression pattern of serum miR-1, miR130, and miR-146 gradually decreased from normal control (NC) to CC to GBC, while miR-21 and miR-182 gradually increased from NC to CC to GBC. +other 36681676 hsa-mir-150 Cardiomyopathies miR5p may be a predictor of sepsis severity development but warrants further study. +lncRNA target 36681521 hsa-mir-16 Diabetic Nephropathies After construction of the multilayer regulatory network, several top DEGs (TP53, MYC, BTG2, VEGFA, PTEN, etc.), as well as top miRNAs (miR-335, miR-16, miR-17, miR-20a, and miR-93), and transcription factors (SP1, STAT3, NF-KB1, RELA, E2F1), were introduced as potential therapeutic targets in DN. +lncRNA target 36681521 hsa-mir-335 Diabetic Nephropathies After construction of the multilayer regulatory network, several top DEGs (TP53, MYC, BTG2, VEGFA, PTEN, etc.), as well as top miRNAs (miR-335, miR-16, miR-17, miR-20a, and miR-93), and transcription factors (SP1, STAT3, NF-KB1, RELA, E2F1), were introduced as potential therapeutic targets in DN. +lncRNA target 36681521 hsa-mir-20a Diabetic Nephropathies After construction of the multilayer regulatory network, several top DEGs (TP53, MYC, BTG2, VEGFA, PTEN, etc.), as well as top miRNAs (miR-335, miR-16, miR-17, miR-20a, and miR-93), and transcription factors (SP1, STAT3, NF-KB1, RELA, E2F1), were introduced as potential therapeutic targets in DN. +other 36681070 hsa-mir-182 Triple Negative Breast Neoplasms 5p miRNAs were upregulated in LA (7.82 times, p < 0.005; 6.12 times, p < 0.005, respectively) and TN breast cancer samples (9.42 times, p < 0.0001; 8.51 times, p < 0.0001) compared to normal tissues. +other 36681070 hsa-mir-96 Triple Negative Breast Neoplasms 5p miRNAs were upregulated in LA (7.82 times, p < 0.005; 6.12 times, p < 0.005, respectively) and TN breast cancer samples (9.42 times, p < 0.0001; 8.51 times, p < 0.0001) compared to normal tissues. +genetics_knock down_promote 36680456 hsa-mir-1206 Lung Neoplasms Moreover, inhibition of miR-1206 could suppress the malignant phenotypes of lung cancer cells, which was attenuated by KLF2 knockdown. +circulation_biomarker_diagnosis_ns 36680208 hsa-mir-141 Schizophrenia 3p, Wnt5a, and Arp2 might be potential clinical blood-based biomarkers or therapeutic targets for schizophrenia. +transcription factor target 36677874 hsa-mir-185 Nasopharyngeal Carcinoma 5p/STIM1 axis may serve as a potentially effective therapeutic target for the treatment of NPC. +circulation_biomarker_diagnosis_ns 36677130 hsa-mir-200a Ovarian Neoplasms In the second experimental series, detection of miRNAs (miRNA-21, miRNA-141, and miRNA-200a) isolated from blood plasma samples collected from patients having a verified diagnosis of ovarian cancer was performed. +circulation_biomarker_diagnosis_ns 36677130 hsa-mir-141 Ovarian Neoplasms In the second experimental series, detection of miRNAs (miRNA-21, miRNA-141, and miRNA-200a) isolated from blood plasma samples collected from patients having a verified diagnosis of ovarian cancer was performed. +circulation_biomarker_diagnosis_ns 36677130 hsa-mir-21 Ovarian Neoplasms In the second experimental series, detection of miRNAs (miRNA-21, miRNA-141, and miRNA-200a) isolated from blood plasma samples collected from patients having a verified diagnosis of ovarian cancer was performed. +other 36676955 hsa-mir-181c Triple Negative Breast Neoplasms Co-treatment of miR-181c-5p mimic and WA (at varying concentration) down-regulated cell cycle progression markers (CDK4 and Cyclin D1) at mRNA and protein levels. +other 36676927 hsa-mir-16 Metabolic Diseases Data showed reduced levels of miR-16 and miR-363 in women with MetS; however, men with one or more risk factors showed higher levels of miR-let-7c and miR-30a. +other 36676927 hsa-let-7c Metabolic Diseases Data showed reduced levels of miR-16 and miR-363 in women with MetS; however, men with one or more risk factors showed higher levels of miR-let-7c and miR-30a. +other 36676927 hsa-mir-363 Metabolic Diseases Data showed reduced levels of miR-16 and miR-363 in women with MetS; however, men with one or more risk factors showed higher levels of miR-let-7c and miR-30a. +transcription factor target 36675268 hsa-mir-5591 Diabetes Mellitus Moreover, the results confirm that the CMF treatment induced a reduction in the ROS production, an increase in the macrophage M2 anti-inflammatory phenotype through the activation of miRNA 5591, a reduction in inflammatory cytokines, such as interleukin-1 (IL-1) and IL-6, an increase in anti-inflammatory ones, such as IL-10 and IL-12 and an increase in the markers related to improved wound healing such as collagen type I and integrins. +other 36675221 hsa-mir-20a Leukemia, Lymphocytic, Chronic, B-Cell In a multivariate analysis, high miR-20a expression remained an independent marker predicting long TTT (time to treatment) for CLL patients. +circulation_biomarker_diagnosis_ns 36675122 hsa-mir-221 Severe Asthma The best multivariate logistic regression model to differentiate individuals with severe asthma, treated and untreated with OCS, was to combine the serum miRNAs hsa-miR +circulation_biomarker_prognosis_up 36675028 hsa-mir-130a Endothelial Dysfunction Hence, serum miR-130a-5p could identify different stages of ED and independently predict CRTd response, therefore representing a novel prognostic HF biomarker. +other 36674994 hsa-mir-151a Neurodevelopmental Disorders This pilot study provides evidence that miR-151a-3p may aid the identification of infants at risk for neurodevelopmental delay. +circulation_biomarker_diagnosis_ns 36674813 hsa-mir-122 Non-alcoholic Fatty Liver Disease miRNA-122, the most abundant liver-specific miRNA, protects hepatic steatosis and inhibits cholesterol and fatty acid synthesis in NAFLD. Previously, we have shown that compared with its expression in healthy controls, miRNA-122 decreased in the liver tissue but gradually increased in the serum of patients with non-alcoholic fatty liver disease and non-alcoholic steatohepatitis, suggesting that miRNA-122 could have been transported to the serum. +lncRNA target 36674797 hsa-mir-200b Heart Failure With the aid of Ago2 CLIP-seq data, luciferase assays verified that RBFox2 was targeted by multiple miRNAs, including Let-7, miR-16, and miR-200b, which were significantly upregulated in heart failure. +lncRNA target 36674797 hsa-mir-16 Heart Failure With the aid of Ago2 CLIP-seq data, luciferase assays verified that RBFox2 was targeted by multiple miRNAs, including Let-7, miR-16, and miR-200b, which were significantly upregulated in heart failure. +lncRNA target 36674797 hsa-let-7 Heart Failure With the aid of Ago2 CLIP-seq data, luciferase assays verified that RBFox2 was targeted by multiple miRNAs, including Let-7, miR-16, and miR-200b, which were significantly upregulated in heart failure. +other 36674758 hsa-mir-375 Mouth Neoplasms Recent advances have suggested that non-coding miRNAs (such as miR-21, miR-27, miR-145, miR-155, miR-365, miR-375 and miR-494) may be involved in multiple aspects of oral cancer chemotherapeutic responsiveness. +other 36674758 hsa-mir-145 Mouth Neoplasms Recent advances have suggested that non-coding miRNAs (such as miR-21, miR-27, miR-145, miR-155, miR-365, miR-375 and miR-494) may be involved in multiple aspects of oral cancer chemotherapeutic responsiveness. +other 36674758 hsa-mir-155 Mouth Neoplasms Recent advances have suggested that non-coding miRNAs (such as miR-21, miR-27, miR-145, miR-155, miR-365, miR-375 and miR-494) may be involved in multiple aspects of oral cancer chemotherapeutic responsiveness. +other 36674758 hsa-mir-494 Mouth Neoplasms Recent advances have suggested that non-coding miRNAs (such as miR-21, miR-27, miR-145, miR-155, miR-365, miR-375 and miR-494) may be involved in multiple aspects of oral cancer chemotherapeutic responsiveness. +other 36674758 hsa-mir-27 Mouth Neoplasms Recent advances have suggested that non-coding miRNAs (such as miR-21, miR-27, miR-145, miR-155, miR-365, miR-375 and miR-494) may be involved in multiple aspects of oral cancer chemotherapeutic responsiveness. +other 36674758 hsa-mir-21 Mouth Neoplasms Recent advances have suggested that non-coding miRNAs (such as miR-21, miR-27, miR-145, miR-155, miR-365, miR-375 and miR-494) may be involved in multiple aspects of oral cancer chemotherapeutic responsiveness. +circulation_biomarker_diagnosis_ns 36674679 hsa-mir-24 Diabetes Mellitus, Type 2 Thus, we can conclude that initial weight and BMI, together with circulating expression levels of hsa-miR +circulation_biomarker_diagnosis_ns 36674679 hsa-mir-24 Diabetes, Gestational Thus, we can conclude that initial weight and BMI, together with circulating expression levels of hsa-miR +other 36674633 hsa-mir-200c Dyslipidemias Finally, a phenotypic correlation performed in the CAD group revealed lower hsa-miR-200c-3p expression levels in CAD patients affected by dyslipidemia (+DLP, n = 58) (p < 0.01). +epigenetics 36674633 hsa-mir-200c Coronary Artery Disease An integrated analysis of genome-wide DNA methylation and miRNA-seq results indicated a significant downregulation of hsa-miR-200c-3p (FCCAD = 2.97, p 0.05) associated to the hypermethylation of two sites (genomic coordinates: chr12:7073122-7073122 and chr12:7072599-7072599) located intragenic to the miR-200c/141 genomic locus (encoding hsa-miR-200c-3p) (p-value = 0.009) in CAD patients. +tissue_expression_ns 36674605 hsa-mir-146a Brain Ischemia These results open the path for a detailed dissection of the molecular consequences of laforin and malin deficiency in brain tissue, as well as the potential role of miR-155 and miR-146a as specific biomarkers of disease progression in LD. +tissue_expression_ns 36674605 hsa-mir-146a Parkinson Disease These results open the path for a detailed dissection of the molecular consequences of laforin and malin deficiency in brain tissue, as well as the potential role of miR-155 and miR-146a as specific biomarkers of disease progression in LD. +tissue_expression_ns 36674605 hsa-mir-155 Brain Ischemia These results open the path for a detailed dissection of the molecular consequences of laforin and malin deficiency in brain tissue, as well as the potential role of miR-155 and miR-146a as specific biomarkers of disease progression in LD. +tissue_expression_ns 36674605 hsa-mir-155 Parkinson Disease These results open the path for a detailed dissection of the molecular consequences of laforin and malin deficiency in brain tissue, as well as the potential role of miR-155 and miR-146a as specific biomarkers of disease progression in LD. +transcription factor target 36674578 hsa-mir-143 Hyalinosis, Systemic Furthermore, miR3p was preferentially expressed in SHFs and Itga6 was identified as one of targets. +other 36674578 hsa-mir-143 Motion Sickness 3p in cashmere growth. +other 36674462 hsa-mir-22 Respiratory Tract Infections Regression analysis identified environmental (daycare attendance, atmospheric pollution, breastfeeding duration), microbial (Verrucomicrobia, Streptococcus phage), and host factors (miR5p) associated with URI frequency (p < 0.05). +lncRNA target 36672938 hsa-mir-204 Endomyocardial Fibrosis By constructing regulatory networks, lincRNA-ZFP42-ACTC1, lincRNA-AMY2-STAT1, and/or lincRNA-AMY2/miR-204/STAT1 were sieved, and the results indicate that lncRNA could participate in IMF deposition through direct regulation or ceRNA. +lncRNA target 36672843 hsa-mir-126 Peripheral Arterial Disease The goal of the study was to verify whether WT promotes angiogenesis in PAD-affected muscle and to investigate the possible role of miRNA-126 and the vascular endothelium growth factor (VEGF) angiogenic pathways on this adaptation. WT promoted angiogenesis in the muscle affected by PAD, and miRNA-126 may have a role in this adaptation by inhibiting PI3KR2, enabling the progression of the VEGF signaling pathway. +circulation_biomarker_diagnosis_up 36672841 hsa-mir-34 Multiple Myeloma We also observed that TP53 and MYC were negatively correlated with mature miR-34 expressions in the plasma cells of patients with MM. +other 36672804 hsa-mir-652 Stomach Neoplasms This work aims to investigate INDELs in the coding region of miRNAs (hsa-miR-302c, hsa-miR-548AJ-2, hsa-miR-4274, hsa-miR-630, hsa-miR-516B-2, hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920, has-mir-3171, and hsa-miR-3652) that may be associated with susceptibility and clinical variants of gastric cancer. The results showed the hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920 and hsa-miR-3652 variants were associated with gastric cancer susceptibility. +other 36672804 hsa-mir-5484 Stomach Neoplasms This work aims to investigate INDELs in the coding region of miRNAs (hsa-miR-302c, hsa-miR-548AJ-2, hsa-miR-4274, hsa-miR-630, hsa-miR-516B-2, hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920, has-mir-3171, and hsa-miR-3652) that may be associated with susceptibility and clinical variants of gastric cancer. The results showed the hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920 and hsa-miR-3652 variants were associated with gastric cancer susceptibility. +other 36672804 hsa-mir-4463 Stomach Neoplasms This work aims to investigate INDELs in the coding region of miRNAs (hsa-miR-302c, hsa-miR-548AJ-2, hsa-miR-4274, hsa-miR-630, hsa-miR-516B-2, hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920, has-mir-3171, and hsa-miR-3652) that may be associated with susceptibility and clinical variants of gastric cancer. The results showed the hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920 and hsa-miR-3652 variants were associated with gastric cancer susceptibility. +other 36672804 hsa-mir-3945 Stomach Neoplasms This work aims to investigate INDELs in the coding region of miRNAs (hsa-miR-302c, hsa-miR-548AJ-2, hsa-miR-4274, hsa-miR-630, hsa-miR-516B-2, hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920, has-mir-3171, and hsa-miR-3652) that may be associated with susceptibility and clinical variants of gastric cancer. The results showed the hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920 and hsa-miR-3652 variants were associated with gastric cancer susceptibility. +other 36672804 hsa-mir-920 Stomach Neoplasms This work aims to investigate INDELs in the coding region of miRNAs (hsa-miR-302c, hsa-miR-548AJ-2, hsa-miR-4274, hsa-miR-630, hsa-miR-516B-2, hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920, has-mir-3171, and hsa-miR-3652) that may be associated with susceptibility and clinical variants of gastric cancer. The results showed the hsa-miR-4463, hsa-miR-3945, hsa-miR-548H_4, hsa-miR-920 and hsa-miR-3652 variants were associated with gastric cancer susceptibility. +other 36672782 hsa-mir-222 Hepatitis E To our knowledge, it is the first time that miR3p has been described as a reference miRNA for use in CHEV sample analyses. +lncRNA target 36672150 hsa-mir-3916 primary biliary cholangitis 1 We established a FOXA1/LINC00663/hsa-miR-3916/SF2-FN axis that provided a potential target for the diagnosis and targeted therapy of cholestatic liver fibrosis. +lncRNA target 36672150 hsa-mir-3916 Fibrosis We established a FOXA1/LINC00663/hsa-miR-3916/SF2-FN axis that provided a potential target for the diagnosis and targeted therapy of cholestatic liver fibrosis. +lncRNA target 36672150 hsa-mir-3916 Cholestasis We established a FOXA1/LINC00663/hsa-miR-3916/SF2-FN axis that provided a potential target for the diagnosis and targeted therapy of cholestatic liver fibrosis. +circulation_biomarker_diagnosis_ns 36672009 hsa-mir-15b Autism Spectrum Disorder Upregulated blood miR-15b-5p *expression may represent a useful diagnostic marker of ASD subjects, and it may regulate TGFBR3 mRNA expression. +other 36671979 hsa-mir-34a Nervous System Diseases Zip nucleic acid (ZNA)-based genomagnetic assay was developed herein for the electrochemical detection of microRNA-34a (miR-34a), which is related to neurological disorders and cancer. +other 36671979 hsa-mir-34a Carcinoma, Hepatocellular To show the applicability of the ZNA-based genomagnetic assay for miR-34a detection in real samples, a batch of experiments was carried out in this study by using the total RNA samples isolated from the human hepatocellular carcinoma cell line (HUH-7). +lncRNA target 36671913 hsa-mir-625 Colorectal Neoplasms 5p promoted cell proliferation and migration but inhibited apoptosis through phenotypic experiments; thus, we initially identified miR +genetics_GWAS 36671508 hsa-mir-146a Osteoarthritis Our genetic and transcriptomic data define a crucial role of miR-146a-5p in OA pathogenesis and implicate modulation of miR-146a-5p in articular chondrocytes as a potential therapeutic strategy to alleviate OA. +other 36671388 hsa-mir-675 Carcinoma, Hepatocellular Oncofetal H19-derived miR-675 expression could be considered a potential noninvasive diagnostic and prognostic biomarker, outstanding the performance of the expression of tissue lncRNA-H19 for HCC. +epigenetics 36670548 hsa-mir-124 Esophageal Squamous Cell Carcinoma MATERIALS AND METHODS: Promoter methylation of miR129-2, miR124-3 and ZNF569 was assessed, using quantitative methylation-specific PCR (qMSP), in tissue samples from normal esophagus, treatment-naive and post-ChRT ECa, as well as in liquid biopsies from ECa patients. DISCUSSION: MiR129-2(me) , miR124-3(me) and ZNF569(me) accurately discriminate ECa, either pre- or post-ChRT, from normal tissue, enabling ECa detection. +other 36670490 hsa-mir-145 Pneumonia, Mycoplasma CONCLUSION: This study provided evidence that the up-regulated hsa_circ_0001326 in PE restrained trophoblast cells proliferation, migration, and invasion by sponging miR5p to elevate TGFB2 expression. +other 36670110 hsa-mir-511 Carcinoma, Hepatocellular In addition, miR5p was expressed at a low level in HCC tissues, was negatively correlated HLTF, and regulated HLTF expression. +lncRNA target 36669583 hsa-mir-9 Carcinoma, Hepatocellular Twist1-YY1-p300 phase-separated condensates were disrupted by metformin (Met) and thus reduce miR-9 expression, thereby inhibiting the malignant progression of HCC. +circulation_biomarker_diagnosis_ns 36662897 hsa-mir-221 Peripheral Nerve Injuries Furthermore, serum miR-221 may be useful as a biomarker of neuropathic pain caused by peripheral nerve injury. +circulation_biomarker_diagnosis_ns 36662897 hsa-mir-221 Neuralgia Furthermore, serum miR-221 may be useful as a biomarker of neuropathic pain caused by peripheral nerve injury. +circulation_biomarker_diagnosis_ns 36662424 hsa-mir-221 Ischemia The revascularization of miR-221/222-transfeted ADSCs was further verified in a rat hind limb ischemia model. Furthermore, injection of miR-221/222 transfected ADSCs significantly improved rat hindlimb ischemia, as evidenced by increased blood flow and structural integrity and reduce inflammatory infiltration. +lncRNA target 36661031 hsa-mir-518a Squamous Cell Carcinoma of Head and Neck CONCLUSION: In vitro lncRNA HOXA11-AS silencing inhibited OSCC stem cell stemness by targeting the miR-518a-3p/PDK1 axis, thus enhancing OSCC cell radiosensitivity. +circulation_biomarker_diagnosis_up 36660723 hsa-mir-21 Lung Injury 3p further decreased the MAP and HR, and increased the levels of syndecan-1 (SDC-1), heparanase-1 (HPA1), interleukin (IL)-6, IL-1beta, and tumor necrosis factor alpha (TNF-alpha) in the serum of the THS rats resuscitated with BRS. +circulation_biomarker_diagnosis_up 36660723 hsa-mir-21 Shock, Hemorrhagic 3p further decreased the MAP and HR, and increased the levels of syndecan-1 (SDC-1), heparanase-1 (HPA1), interleukin (IL)-6, IL-1beta, and tumor necrosis factor alpha (TNF-alpha) in the serum of the THS rats resuscitated with BRS. +target gene 36660663 hsa-mir-202 Adenocarcinoma of Lung MiR-202-3p inhibits the proliferation and metastasis of lung adenocarcinoma cells by targeting RRM2. +exosome 36660623 hsa-mir-146a Carcinoma, Non-Small-Cell Lung Tumor cell-derived exosomal microRNA-146a promotes non-small cell lung cancer cell invasion and proliferation by inhibiting M1 macrophage polarization. +genetics_overexpression_suppress 36660616 hsa-mir-145 Syphilis Additionally, overexpression of TLR4 reversed the protein expression associated with pyroptosis in M2 macrophage-derived exosome miR +other 36660602 hsa-mir-20a Uterine Cervical Neoplasms quercetin increased the expression of mir-26b, mir-126, and mir-320a precursors in HeLa cells. +other 36660602 hsa-mir-126 Uterine Cervical Neoplasms quercetin increased the expression of mir-26b, mir-126, and mir-320a precursors in HeLa cells. +other 36660602 hsa-mir-26b Uterine Cervical Neoplasms quercetin increased the expression of mir-26b, mir-126, and mir-320a precursors in HeLa cells. +exosome 36660450 hsa-mir-210 Epilepsy Exosomal miR-210 from MSCs attenuated neuronal inflammation and contributed to neurogenesis possibly by inhibiting microglial M1 polarization. +lncRNA target 36660176 hsa-mir-204 Myocardial Reperfusion Injury 5p/FBXW7 axis in myocardial IR injury, and DLX6-AS1 may be a potential target for the treatment of myocardial IR injury. +other 36660044 hsa-mir-10b Pancreatic Carcinoma The microRNA panel (miR-10b, miR-21, miR-30c, miR-181a, and miR-let7a), mRNA panel (ARG1, CD63, CK18, Erbb3, GAPDH, H3F3A, KRAS, ODC1), and GPC 1 showed a perfect AUC of 1.0. +other 36660044 hsa-let-7a Pancreatic Carcinoma The microRNA panel (miR-10b, miR-21, miR-30c, miR-181a, and miR-let7a), mRNA panel (ARG1, CD63, CK18, Erbb3, GAPDH, H3F3A, KRAS, ODC1), and GPC 1 showed a perfect AUC of 1.0. +other 36660044 hsa-mir-21 Pancreatic Carcinoma The microRNA panel (miR-10b, miR-21, miR-30c, miR-181a, and miR-let7a), mRNA panel (ARG1, CD63, CK18, Erbb3, GAPDH, H3F3A, KRAS, ODC1), and GPC 1 showed a perfect AUC of 1.0. +other 36660044 hsa-mir-181a Pancreatic Carcinoma The microRNA panel (miR-10b, miR-21, miR-30c, miR-181a, and miR-let7a), mRNA panel (ARG1, CD63, CK18, Erbb3, GAPDH, H3F3A, KRAS, ODC1), and GPC 1 showed a perfect AUC of 1.0. +circulation_biomarker_diagnosis_ns 36659877 hsa-mir-16 Sepsis Through plasma miRNAomics studies, we identified four miRNAs (hsa-miR +circulation_biomarker_diagnosis_ns 36659877 hsa-mir-451a Sepsis Through plasma miRNAomics studies, we identified four miRNAs (hsa-miR +circulation_biomarker_diagnosis_ns 36659877 hsa-mir-423 Sepsis Through plasma miRNAomics studies, we identified four miRNAs (hsa-miR +circulation_biomarker_diagnosis_ns 36659877 hsa-mir-185 Sepsis Through plasma miRNAomics studies, we identified four miRNAs (hsa-miR +genetics_knock down_promote 36659830 hsa-mir-1277 Endometrial Neoplasms Besides that, MFGE8 overexpression also attenuated the inhibitory action of miR +lncRNA target 36658478 hsa-mir-1192 Spinal Cord Injuries CONCLUSIONS: Our study clarified that the lncRNA TUG1/miR-1192/TLR3 axis is an important pathway for PBM to inhibit M1 macrophage polarization and inflammation, which provides theoretical support for its clinical application in patients with SCI. +lncRNA target 36658474 hsa-mir-142 Colitis, Ulcerative 5p was found to be highly expressed in UC, and its silencing inhibited LPS-stimulated Caco-2 cell apoptosis and inflammatory responses. +transcription factor target 36658407 hsa-mir-381 Leukemia, Myeloid, Acute 3p as the tumor suppressor within pediatric AML by targeting ROCK1. +genetics_overexpression_promote 36658310 hsa-mir-195 Adenocarcinoma of Lung 5p overexpression. +circulation_biomarker_diagnosis_ns 36657657 hsa-mir-195 Adenocarcinoma of Lung 5p expression in circulating exosomes of LAC patients was lower than that of healthy controls. +lncRNA target 36657426 hsa-mir-483 Colorectal Neoplasms Conclusion The results suggested that BCAR4/miR3p/RAB5C axis has the potential to be explored as a novel therapeutic target for CRC treatment. +lncRNA target 36657061 hsa-mir-98 Ovarian Neoplasms CONCLUSION: SNHG4 accelerates OC development via mediating the miR +other 36656656 hsa-mir-145 Plaque, Atherosclerotic In vivo, this treatment reduced the atherosclerotic plaque area by 48.04% compared with treatment with free miR-145. +genetics_knock down_suppress 36656536 hsa-mir-93 Urinary Bladder Neoplasms Knockdown miRNA +lncRNA target 36656498 hsa-mir-450b Reperfusion Injury This paper tested the hypothesis that Res could protect against cerebral ischemia-reperfusion injury (CI/RI) by modulating microglial polarization via the miR-450b-5p/KEAP1/Nrf2 pathway. Our study demonstrates that Res exerts neuroprotective effects on microglial M2 polarization through the miR-450b-5p/KEAP1/Nrf2 pathway during CI/RI. +circulation_biomarker_diagnosis_up 36656380 hsa-mir-133a Breast Neoplasms METHODS: The expressions of miR-133a, miR-637, miR-944, PI3K, and AKT genes were examined in the tumor and tumor margin tissues of 40 patients with breast cancer, as well as the serum levels of miR-133a, miR-637, and miR-944 in these patients and 40 healthy groups by quantitative real-time PCR (qRT-PCR). +circulation_biomarker_diagnosis_up 36656380 hsa-mir-637 Breast Neoplasms METHODS: The expressions of miR-133a, miR-637, miR-944, PI3K, and AKT genes were examined in the tumor and tumor margin tissues of 40 patients with breast cancer, as well as the serum levels of miR-133a, miR-637, and miR-944 in these patients and 40 healthy groups by quantitative real-time PCR (qRT-PCR). +circulation_biomarker_diagnosis_up 36656380 hsa-mir-944 Breast Neoplasms METHODS: The expressions of miR-133a, miR-637, miR-944, PI3K, and AKT genes were examined in the tumor and tumor margin tissues of 40 patients with breast cancer, as well as the serum levels of miR-133a, miR-637, and miR-944 in these patients and 40 healthy groups by quantitative real-time PCR (qRT-PCR). +circRNA target 36655489 hsa-mir-124 Fibrosis Considering the important role of miR-124 in regulating liver fibrosis and HSCs activation, imatinib may exert its anti-fibrotic activity through miR-124. +other 36655275 hsa-mir-181a Colonic Neoplasms Collectively, LINC01232 enhances the proliferation, migration, invasion, and angiogenesis of COAD cells by decreasing miR-181a-5p expression. +genetics_overexpression_promote 36654514 hsa-mir-526b Triple Negative Breast Neoplasms Overexpression of miR-526b in TNBC cells decreased the expression levels of SLC16A1-AS1, while overexpression of SLC16A1-AS1 did not affect the expression of miR-526b. +lncRNA target 36653891 hsa-mir-28 Diabetes, Gestational CONCLUSION: Our study provides evidence that the lncRNA TUG1 may prevent IR following GDM through competitively binding to miR +virus_miRNA 36653806 hcmv-mir-UL22A Aortic Dissection hcmv-miR-UL22A-5p high levels in the plasma of Aortic dissection patients +virus_miRNA 36653806 hcmv-mir-UL112 Aortic Dissection hcmv-miR-UL112-5p high levels in the plasma of Aortic dissection patients +lncRNA target 36653745 hsa-mir-155 Retinal Diseases CONCLUSIONS: Finally, our study identifies the lncRNA uc007nnj.1/miR5p/Tle4 axis as a potential target for the prevention of I/R-induced retinal neuronal death. +other 36653745 hsa-mir-155 Ischemia DISCUSSION: Mechanistically, the results demonstrated that lncRNA uc007nnj.1 acts as ceRNA competitively binding miR5p, thereby enhancing the expression levels of Tle4, thus aggravating ischemia-related apoptosis in RGCs. +lncRNA target 36653745 hsa-mir-155 familial febrile seizures 1 5p/Tle4 axis as a potential target for the prevention of I/R-induced retinal neuronal death. +transcription factor target 36653507 hsa-mir-35 Breast Neoplasms We studied the role of miR-335 and -145 on PD-L1 suppression in breast cancer. In summary, we found that miR-335 and -145 are novel tumor suppressors inactivated in BC, and these miRs may serve as potential therapeutic targets for breast cancer treatment. +exosome 36652132 hsa-mir-1827 Colorectal Neoplasms These findings indicate hUC-MSCs-Exos as an inhibitor of M2 macrophage polarization and liver metastasis in CRC through inducing miR +lncRNA target 36651361 hsa-mir-140 Breast Neoplasms 5p suppressed tumor progression of breast carcinoma cells through inhibition of the AKT/STAT3/NF-kappaB pathway. +transcription factor target 36651333 hsa-mir-146a Diabetes Mellitus We further observed that miR-146a-5p regulates the mRNA and protein expression of TXNIP in vitro, indicating that the miR-146a-5p/TXNIP axis is involved in the regulation of cognitive dysfunction in a rat diabetic model. Collectively, these results demonstrate that RSV plays a neuroprotective role in diabetes-associated cognitive dysfunction at least in part through regulation of the miR-146a-5p/TXNIP axis. +transcription factor target 36651333 hsa-mir-146a Cognition Disorders We further observed that miR-146a-5p regulates the mRNA and protein expression of TXNIP in vitro, indicating that the miR-146a-5p/TXNIP axis is involved in the regulation of cognitive dysfunction in a rat diabetic model. Collectively, these results demonstrate that RSV plays a neuroprotective role in diabetes-associated cognitive dysfunction at least in part through regulation of the miR-146a-5p/TXNIP axis. +other 36651169 hsa-mir-188 Pre-Eclampsia CONCLUSION: Our study demonstrated that circ_0001326 could promote trophoblast cell proliferation, invasion, migration and EMT in PE by miR3p/HTRA1 axis, indicating a novel insight into the pathogenesis of PE. +lncRNA target 36650622 hsa-mir-140 Lipodystrophy, Partial, Acquired Inhibition of miR3p attenuated LRRC75A-AS1 deficiency-induced up-regulation of COL II, aggrecan and SOX9. +genetics_knock down_promote 36650344 hsa-mir-944 Tongue Neoplasms We demonstrate that proliferation, migration, and invasion of tongue cancer cells are suppressed by MMP10 knockdown or miR-944 overexpression. +lncRNA target 36650131 hsa-mir-181a Osteoporosis Our results demonstrated that the WTAP/YTHDC1/miR-181a and miR-181c/SFRP1 axis regulated the differentiation fate of BMSCs, suggesting that it might be a potential therapeutic target for osteoporosis. +lncRNA target 36650131 hsa-mir-181c Osteoporosis Our results demonstrated that the WTAP/YTHDC1/miR-181a and miR-181c/SFRP1 axis regulated the differentiation fate of BMSCs, suggesting that it might be a potential therapeutic target for osteoporosis. +circulation_biomarker_diagnosis_up 36649032 hsa-mir-34a Glioblastoma 5p have shown to act as tumour suppressors or oncomiRs in different neoplasms, including GBM. +circulation_biomarker_diagnosis_up 36649032 hsa-mir-206 Glioblastoma 5p have shown to act as tumour suppressors or oncomiRs in different neoplasms, including GBM. +circulation_biomarker_diagnosis_up 36649032 hsa-mir-128 Glioblastoma 5p have shown to act as tumour suppressors or oncomiRs in different neoplasms, including GBM. +circulation_biomarker_diagnosis_up 36649032 hsa-mir-21 Glioblastoma 5p have shown to act as tumour suppressors or oncomiRs in different neoplasms, including GBM. +circulation_biomarker_diagnosis_up 36649032 hsa-mir-136 Glioblastoma 5p have shown to act as tumour suppressors or oncomiRs in different neoplasms, including GBM. +circulation_biomarker_diagnosis_up 36649032 hsa-mir-512 Glioblastoma 5p have shown to act as tumour suppressors or oncomiRs in different neoplasms, including GBM. +other 36648863 hsa-mir-26b hereditary diffuse gastric cancer 5p). +other 36648863 hsa-mir-22 Colorectal Neoplasms 5p). +other 36648863 hsa-mir-16 hereditary diffuse gastric cancer 5p). +other 36648863 hsa-mir-21 Colorectal Neoplasms 5p). +other 36648863 hsa-mir-21 hereditary diffuse gastric cancer 5p). +other 36648863 hsa-mir-126 hereditary diffuse gastric cancer 5p). +other 36648863 hsa-mir-26b Colorectal Neoplasms 5p). +other 36648863 hsa-mir-133a Colorectal Neoplasms 5p). +other 36648863 hsa-mir-25 hereditary diffuse gastric cancer 5p). +other 36648863 hsa-mir-17 Colorectal Neoplasms 5p). +other 36648863 hsa-mir-186 Colorectal Neoplasms 5p). +other 36648863 hsa-mir-126 Colorectal Neoplasms 5p). +other 36648863 hsa-mir-92a hereditary diffuse gastric cancer 5p). +other 36648863 hsa-mir-183 hereditary diffuse gastric cancer 5p). +other 36648863 hsa-mir-22 hereditary diffuse gastric cancer 5p). +other 36648863 hsa-mir-133a hereditary diffuse gastric cancer 5p). +other 36648863 hsa-mir-92a Colorectal Neoplasms 5p). +other 36648863 hsa-mir-186 hereditary diffuse gastric cancer 5p). +other 36648863 hsa-mir-183 Colorectal Neoplasms 5p). +other 36648863 hsa-mir-17 hereditary diffuse gastric cancer 5p). +other 36648863 hsa-mir-25 Colorectal Neoplasms 5p). +other 36648863 hsa-mir-16 Colorectal Neoplasms 5p). +circulation_biomarker_diagnosis_ns 36648741 hsa-mir-21 Fibrosis, Renal CONCLUSION: High blood TGF-beta1 and miR-21 expression at diagnosis of IgAN show significant correlation with renal function and degree of chronic tubulointerstitial injury on histology. +circulation_biomarker_diagnosis_ns 36648741 hsa-mir-21 Glomerulonephritis, IGA CONCLUSION: High blood TGF-beta1 and miR-21 expression at diagnosis of IgAN show significant correlation with renal function and degree of chronic tubulointerstitial injury on histology. +exosome 36648415 hsa-mir-145 Myopia, Degenerative 5p can be considered biomarkers for patients with PM, and the vitreous exosomal DEM associated with PM-H may represent alarming signals of myopic maculopathy deterioration. +exosome 36648415 hsa-mir-143 Myopia, Degenerative 5p can be considered biomarkers for patients with PM, and the vitreous exosomal DEM associated with PM-H may represent alarming signals of myopic maculopathy deterioration. +other 36648259 hsa-mir-145 Breast Neoplasms CONCLUSIONS: ICORG10/11 is the first Irish multicenter, translational research trial evaluating circulatory miRNAs as biomarkers predictive of long-term survival and correlated increased miR-145 expression with enhanced outcomes in early-stage breast cancer. +lncRNA target 36648213 hsa-mir-455 Depression 3p targets PSD-95 and co-regulates NR2B-PSD +lncRNA target 36647717 hsa-mir-194 Epilepsy, Temporal Lobe Overall, our findings indicated that GA exerts protective effects on TLE young rats against neuronal injury by inhibiting ferroptosis through the miR +lncRNA target 36646789 hsa-mir-139 Pancreatic Carcinoma Pancreatic cancer cells gain LPAR4 expression in response to stress by downregulating a tumour suppressor, miR5p. +circulation_biomarker_diagnosis_up 36646015 hsa-mir-133a Myocardial Infarction, Acute Here, proposing the design that DNA photonic wire (PW) with no spectral crosstalk would make an excellent template for miRNA conjoint analysis, we report the construction of a miRNA addition probe for the additive analysis of two up-regulated miRNAs (miR-133a and miR-208a) for early diagnosis of AMI in clinical serum samples. +circulation_biomarker_diagnosis_up 36646015 hsa-mir-208a Myocardial Infarction, Acute Here, proposing the design that DNA photonic wire (PW) with no spectral crosstalk would make an excellent template for miRNA conjoint analysis, we report the construction of a miRNA addition probe for the additive analysis of two up-regulated miRNAs (miR-133a and miR-208a) for early diagnosis of AMI in clinical serum samples. +lncRNA target 36646008 hsa-mir-223 Pneumonia 3p on its target NLRP3 was suppressed by circPWWP2A, which led to lung fibrosis. +transcription factor target 36645633 hsa-mir-193 Atherosclerosis Thus, miR5p/SRSF10 may serve as a novel treatment target for atherosclerosis. +circRNA target 36645579 hsa-mir-205 Uterine Cervical Neoplasms Circ_0000078 inhibits the growth of cancer by interfering with the miR5p/EREG network, acting as a tumor suppressor in CC. +other 36645554 hsa-mir-135b Breast Neoplasms mediated gene silencing involved in the ceRNA network of TNBC. +circulation_biomarker_diagnosis_down 36644827 hsa-mir-215 Prostatic Neoplasms Furthermore, miR-527 was shown to be significantly downexpressed with fold changes of 0.6018 (p - 0.0095) and 0.6917 (p - 0.0155) in plasma and tissue samples, respectively.ConclusionAccording to our findings, plasma miR-190b-5p, miR5p, miR-527 levels alteration is consistently linked with PCa tissue. +circulation_biomarker_diagnosis_down 36644827 hsa-mir-527 Prostatic Neoplasms Furthermore, miR-527 was shown to be significantly downexpressed with fold changes of 0.6018 (p - 0.0095) and 0.6917 (p - 0.0155) in plasma and tissue samples, respectively.ConclusionAccording to our findings, plasma miR-190b-5p, miR5p, miR-527 levels alteration is consistently linked with PCa tissue. +circulation_biomarker_diagnosis_down 36644827 hsa-mir-190b Prostatic Neoplasms Furthermore, miR-527 was shown to be significantly downexpressed with fold changes of 0.6018 (p - 0.0095) and 0.6917 (p - 0.0155) in plasma and tissue samples, respectively.ConclusionAccording to our findings, plasma miR-190b-5p, miR5p, miR-527 levels alteration is consistently linked with PCa tissue. +exosome 36644823 hsa-mir-29c Ovarian Neoplasms Among the miRNAs downregulated in CAF-Exo, miR-29c-3p in OC tissues was associated with metastasis and survival in patients. These results verify the significant contribution of exosomes from omental CAFs to OC peritoneal metastasis, which could be partially due to the relief of MMP2 expression inhibition mediated by low exosomal miR-29c-3p. +lncRNA target 36644819 hsa-mir-625 Nasopharyngeal Neoplasms Our results suggest that the circLASP1/miR-625 axis is involved the therapeutic effects of MK-2206 on NPC by regulating autophagy, proliferation, and apoptosis through the AKT/mTOR pathway. +other 36644780 hsa-mir-1525 Influenza, Human SARS-cov2 and influenza A virus regulation have been connected to ZFP36L1 from miRNA 1525 and ETV5 from miRNA 756, respectively. +other 36644193 hsa-mir-195 Carcinoma, Hepatocellular The homo sapiens-microRNA-195 (hsa-miR-195) may have contributed to the upregulation of CHEK1 in HCC. +genetics_GWAS 36644163 hsa-mir-100 Biliary Atresia METHODS: We conducted a case-control retrospective study to explore the correlation between miR-100 gene polymorphism (rs1834306 A>G) and biliary atresia susceptibility in 484 Chinese patients and 1445 matched control subjects. +exosome 36643863 hsa-mir-589 Stomach Neoplasms CircSTAU2 could be wrapped in exosomes and delivered to recipient cells, and functioned as a sponge for miR-589 to relieve its inhibitory effect on CAPZA1, thus inhibiting GC progression. CONCLUSION: Exosome-delivered circSTAU2 may act as a tumor suppressor that restrains GC progression via miR-589/CAPZA1 axis, which demonstrates a potential therapeutic target for GC. +other 36643677 hsa-mir-6833 Bronchopulmonary Dysplasia CONCLUSIONS: This study identified 1 key upregulated lncRNA (i.e., MERGE.57185.1) in preterm neonatal BPD, and revealed the MERGE.57185.1/hsa-miR5p/EIF5A mechanism in preterm neonatal BPD from the lncRNA-miRNA-mRNA network. +exosome 36643646 hsa-let-7b Lung Neoplasms CONCLUSIONS: M1-Exos inhibit the proliferation, invasion, and metastasis of lung cancer cells through miRNA-let-7b-5p and GNG5 signaling pathways and inhibit the anti-apoptotic ability of lung cancer cells. +target gene 36643496 hsa-mir-34a Ischemic Stroke Gentamycin Rationally Repositioned to Inhibit miR-34a Ameliorates Oxidative Injury to PC12 Cells. +other 36643367 hsa-mir-196b Stomach Neoplasms TCGA data showed a high expression of miR-196b-3p in gastric cancer cases (P < .001). +circRNA target 36643258 hsa-mir-487a Squamous Cell Carcinoma of Head and Neck CONCLUSION: Circ_0005050 acted as an oncogenic factor in OSCC progression through miR-487a-3p/CHSY1 axis. +genetics_knock down_suppress 36643221 hsa-mir-2278 Squamous Cell Carcinoma of Head and Neck GNAS knockdown restored miR-2278 inhibitor-mediated effect in OSCC cells. +exosome 36642417 hsa-mir-9 Osteoarthritis Intra-articular injection of exosomal miR +other 36642194 hsa-mir-132 Ovarian Neoplasms These findings suggested ovarian and uterine dysplasia in the offspring induced by gestational VCZ-exposure were mainly attributed to higher miR-132 and miR-195a and accentuated Hippo-pathway. +other 36642194 hsa-mir-195 Ovarian Neoplasms These findings suggested ovarian and uterine dysplasia in the offspring induced by gestational VCZ-exposure were mainly attributed to higher miR-132 and miR-195a and accentuated Hippo-pathway. +exosome 36642112 hsa-mir-211 Melanoma We show that the highly metastatic melanoma tumor cells (POL) can transfer their metastatic competency to the low-metastatic melanoma tumor cells (OL) by exosomal miR5p. +transcription factor target 36641890 hsa-mir-155 Cognition Disorders In silico analyses identified the prolactin signaling pathway, miR5p, miR-34a-5p, and CEBPB as the main molecular mechanisms involved in the pathophysiology of DAB-induced cognitive impairment and targeted by risperidone. +transcription factor target 36641890 hsa-mir-34a Cognition Disorders In silico analyses identified the prolactin signaling pathway, miR5p, miR-34a-5p, and CEBPB as the main molecular mechanisms involved in the pathophysiology of DAB-induced cognitive impairment and targeted by risperidone. +genetics_overexpression_promote 36641136 hsa-mir-196b Glomerulonephritis, IGA Inhibition of PTEN rescued the therapeutic effects of overexpression of FGD5-AS1 or inhibition of miR-196b-5p on IgAN. +circulation_biomarker_diagnosis_ns 36640912 hsa-mir-128 Precursor Cell Lymphoblastic Leukemia-Lymphoma CONCLUSION: Our results show that circulating miRs are potential biomarkers of ALL MRD, asmiR3p level both in PFP and EEF predicts day 15 FC MRD. +exosome 36640325 hsa-mir-27b Atherosclerosis Thus, obesity-induced exosomal miR-27b-3p promotes endothelial inflammation and facilitates atherogenesis by PPARalpha suppression. +circulation_biomarker_diagnosis_ns 36640195 hsa-mir-223 Acute Kidney Injury 3p and SNRK expression and high HDAC2 expression in peripheral blood. +other 36640056 hsa-mir-4717 Arthritis, Rheumatoid The expression levels of miR-28, miR-138, and miR-4717 were significantly downregulated in the NK cells from RA patients compared to the healthy group. +other 36640056 hsa-mir-138 Arthritis, Rheumatoid The expression levels of miR-28, miR-138, and miR-4717 were significantly downregulated in the NK cells from RA patients compared to the healthy group. +other 36640056 hsa-mir-28 Arthritis, Rheumatoid The expression levels of miR-28, miR-138, and miR-4717 were significantly downregulated in the NK cells from RA patients compared to the healthy group. +other 36639978 hsa-mir-590 Dermatitis, Atopic Morinda officinalis extract exhibits protective effects against atopic dermatitis by regulating the MALAT1/miR-590-5p/CCR7 axis. +genetics_knock down_suppress 36639866 hsa-mir-181a Colorectal Neoplasms Circ-ERBB2 knockdown sensitized colorectal cancer cells to 5-FU via miR-181a-5p/PTEN/Akt pathway. +other 36639835 hsa-mir-22 Tongue Neoplasms We also detected activation of miR-22/lncRNA/KAT6B/NF-kappaB signalling in recurrent cancers compared to paired primary tongue cancers. +genetics_GWAS 36639674 hsa-mir-92a-1 Diabetic Nephropathies 5p epigenetic regulatory network could be a potential therapeutic strategy to prevent the progression of DN. +lncRNA target 36639265 hsa-mir-195 Breast Neoplasms Breast cancer cell proliferation was regulated by the SNHG16/miR-195/PCMT1 axis. CONCLUSION: PCMT1 silencing inhibited cell proliferation and invasion and induced apoptosis in breast cancer cells and the SNHG16/miR-195/PCMT1 regulatory axis might serve as a potential therapeutic target for breast cancer. +other 36639145 hsa-mir-122 Liver Injury We describe miR-122 concentrations in participants with antituberculosis drug-induced liver injury (AT-DILI). CONCLUSIONS: miR-122 concentrations in our participants with AT-DILI were considerably higher than previously reported in healthy volunteers and in patients on antituberculosis therapy without liver injury. +exosome 36638658 hsa-mir-99b Neuralgia Collectively, our findings demonstrated that MSC-EVs had an analgesic effect on neuropathic pain via promoting autophagy, and these antinociceptive effects were at least in part caused by MSC-EV-mediated transfer of miR-99b-3p, thereby inhibiting microglial activation and pro-inflammatory cytokines expression. +other 36637626 hsa-mir-17 Glioblastoma 5p, and Caspase 3 as apoptosis predictors in the GM patients. +other 36637626 hsa-mir-20 Glioblastoma 5p, and Caspase 3 as apoptosis predictors in the GM patients. +circRNA target 36637163 hsa-mir-135a Carcinoma, Non-Small-Cell Lung Taken together, circ-N4BP2L2 enhanced NSCLC progression via the miR-135a-5p/ARL5B axis, which may provide a novel therapeutic target of NSCLC. +circulation_biomarker_diagnosis_up 36636641 hsa-mir-10527 Esophageal Squamous Cell Carcinoma 5p was found to be notably reduced in both the plasma exosomes and tumor tissues of ESCC patients with LNM, and plasma exosomal miR +exosome 36636640 hsa-mir-133a Reperfusion Injury, Cerebral Ischemia Furthermore, exosomal miR-133a-3p derived from BMSCs markedly alleviated the symptom of CI/R injury in vivo. CONCLUSION: Exosomal miR-133a-3p derived from BMSCs alleviates CI/R injury via targeting DAPK2/Akt signaling. +circulation_biomarker_prognosis_ns 36636634 hsa-mir-342 Lupus Erythematosus, Systemic Meanwhile, the low expression level of serum miR +genetics_overexpression_promote 36636455 hsa-mir-653 Adenocarcinoma of Lung 5p to AGR2 and stepwise upregulated AGR2 overexpression in LUAD gefitinib resistant cells, resulting gefitinib resistance in LUAD. +lncRNA target 36636079 hsa-mir-6788 Stomach Neoplasms GC therapy may be improved by conducting targeted studies of the CNALPTC1/miR +transcription factor target 36636078 hsa-mir-17 Colorectal Neoplasms 5p promoted CRC cell proliferation, metastasis, and invasion, while inhibiting apoptosis. +other 36636074 hsa-mir-125b-1 Colorectal Neoplasms The miRNA125a-5p and miRNA125b-1-5p cluster induces cell invasion by down-regulating DDB2-reduced epithelial-to-mesenchymal transition (EMT) in colorectal cancer. +other 36636074 hsa-mir-125a Colorectal Neoplasms The miRNA125a-5p and miRNA125b-1-5p cluster induces cell invasion by down-regulating DDB2-reduced epithelial-to-mesenchymal transition (EMT) in colorectal cancer. +lncRNA target 36636064 hsa-mir-204 Stomach Neoplasms NORAD also regulated KMT2D expression by targeting miR5p and mediated PTEN/PI3K/AKT signaling in GC. +lncRNA target 36636050 hsa-mir-767 Stomach Neoplasms 3p-CHD4 axis, which is associated with GC proliferation and carcinogenesis, and may represent a promising therapeutic target for the future cure of GC. +genetics_knock down_promote 36636045 hsa-mir-543 Pancreatic Carcinoma MicroRNA-543 knockdown dramatically increased PC cell growth, invasion, metastasis, and EMT, as well as decreased apoptosis in functional studies. +other 36636042 hsa-mir-62 Colorectal Neoplasms circ_0000799 promotes proliferation and invasion in CRC and EMT. These effects of circ_0000799 may be achieved by negatively regulating miR-62. +exosome 36635928 hsa-mir-125a Nasopharyngeal Carcinoma RESULTS: miR-125a-5p was highly expressed in NPC tissues and cells. CONCLUSIONS: GS promoted exosomal circFIP1L1 in NPC cells to mediate miR-125a-5p/VEGFA axis affecting tumor angiogenesis. +lncRNA target 36635757 hsa-mir-139 Glioblastoma CONCLUSIONS: According to our research, circNDC80 is an oncogenic factor that promotes glioblastoma through the miR5p/ECE1 pathway. +circRNA target 36635458 hsa-mir-145 Squamous Cell Carcinoma of Head and Neck CONCLUSION: CircZNF236 modulates OSCC via the miR +lncRNA target 36635290 hsa-mir-142 Carcinoma, Hepatocellular 3p by ST8SIA6-AS1 accelerated the growth of cells while preventing cell apoptosis in LIHC cells, and the inhibitory effect of miR +genetics_knock down_promote 36635223 hsa-mir-625 Carcinoma, Squamous Cell, Cutaneous Circ_0001402 knockdown can suppress the development and chemoresistance of DDP-resistant CSCC cells at least partly through targeting miR +genetics_overexpression_suppress 36634743 hsa-mir-654 Craniosynostosis radial aplasia syndrome The inhibition of NEAT1 overexpression on apoptosis and autophagy in OGCs was reversed by miR-654 mimics. +circRNA target 36633774 hsa-mir-339 Colorectal Neoplasms 3p inhibitor partly attenuated this effect. +target gene 36633773 hsa-mir-1304 Lung Neoplasms Circ_0060937 Contributes to the Development of Lung Cancer via Positively Regulating LAD1 Expression by Binding to miR-1304-5p. +genetics_overexpression_suppress 36633140 hsa-mir-212 Metabolic Associated Fatty Liver Disease Conversely, the overexpression of miR2123p abolished the ameliorative effects of exercise on MAFLD. +other 36632887 hsa-mir-21 Glioblastoma INTRODUCTION: miRNA-21 (miR-21) is highly expressed in glioblastoma, facilitating tumor growth by blocking the expression of apoptosis-related genes. Therefore, an antisense microRNA oligonucleotide (AMO) against miR-21 was suggested as a therapeutic nucleic acid for glioblastoma. +other 36632615 hsa-mir-5088 Breast Neoplasms Our previous study confirmed that miR5p was associated with malignancy and metastasis in breast cancer. +transcription factor target 36632614 hsa-mir-1290 Liver Cirrhosis Accordingly, CD133/EpCAM-expressing cells, miR-1290, and miR-1825, could serve as promising diagnostic and prognostic biomarkers as well as therapeutic targets in patients suffering from liver cirrhosis or HCC. +transcription factor target 36632614 hsa-mir-1290 Liver Neoplasms Accordingly, CD133/EpCAM-expressing cells, miR-1290, and miR-1825, could serve as promising diagnostic and prognostic biomarkers as well as therapeutic targets in patients suffering from liver cirrhosis or HCC. +transcription factor target 36632614 hsa-mir-1825 Liver Neoplasms Accordingly, CD133/EpCAM-expressing cells, miR-1290, and miR-1825, could serve as promising diagnostic and prognostic biomarkers as well as therapeutic targets in patients suffering from liver cirrhosis or HCC. +transcription factor target 36632614 hsa-mir-1825 Liver Cirrhosis Accordingly, CD133/EpCAM-expressing cells, miR-1290, and miR-1825, could serve as promising diagnostic and prognostic biomarkers as well as therapeutic targets in patients suffering from liver cirrhosis or HCC. +transcription factor target 36632614 hsa-mir-1290 Carcinoma, Hepatocellular Accordingly, CD133/EpCAM-expressing cells, miR-1290, and miR-1825, could serve as promising diagnostic and prognostic biomarkers as well as therapeutic targets in patients suffering from liver cirrhosis or HCC. +transcription factor target 36632614 hsa-mir-1825 Carcinoma, Hepatocellular Accordingly, CD133/EpCAM-expressing cells, miR-1290, and miR-1825, could serve as promising diagnostic and prognostic biomarkers as well as therapeutic targets in patients suffering from liver cirrhosis or HCC. +lncRNA target 36632453 hsa-mir-1303 Osteosarcoma APLN increased PLOD2 expression in human osteosarcoma cell lines and cell migration via the mammalian Sterile 20-like kinase 1 (MST1), monopolar spindle-one-binder protein (MOB)1, and YAP cascades, and through hsa_circ_0000004 functioning as a sponge of miR-1303. +genetics_overexpression_promote 36631876 hsa-mir-193b Pancreatic Carcinoma miR-193b-3p and TRIM62 were overexpressed or silenced to examine their function in PC. +other 36631465 hsa-mir-33a Melanoma Last, a long non-coding (lncRNA) NEAT1/miR-33a-5p/IRS2 regulatory axis of the competing endogenous RNA network was built to investigate the mechanisms of SKCM metastasis progression. These findings highlight the regulatory axis of the lncRNA NEAT1/miR-33a-5p/IRS2, which may play a role in SKCM metastasis. +circulation_biomarker_diagnosis_ns 36631039 hsa-mir-200c Takayasu Arteritis 5p, KLKB1, KNG1, and DSP carried by exosomes in plasma might participate in the pathogenesis of TAK by regulating vascular physiology, inflammation, autoimmunity, and other processes. +circulation_biomarker_diagnosis_ns 36631039 hsa-mir-21 Takayasu Arteritis 5p, KLKB1, KNG1, and DSP carried by exosomes in plasma might participate in the pathogenesis of TAK by regulating vascular physiology, inflammation, autoimmunity, and other processes. +circulation_biomarker_diagnosis_ns 36631039 hsa-mir-34a Takayasu Arteritis 5p, KLKB1, KNG1, and DSP carried by exosomes in plasma might participate in the pathogenesis of TAK by regulating vascular physiology, inflammation, autoimmunity, and other processes. +circulation_biomarker_diagnosis_ns 36631039 hsa-mir-22 Takayasu Arteritis 5p, KLKB1, KNG1, and DSP carried by exosomes in plasma might participate in the pathogenesis of TAK by regulating vascular physiology, inflammation, autoimmunity, and other processes. +circulation_biomarker_diagnosis_ns 36631039 hsa-mir-143 Takayasu Arteritis 5p, KLKB1, KNG1, and DSP carried by exosomes in plasma might participate in the pathogenesis of TAK by regulating vascular physiology, inflammation, autoimmunity, and other processes. +genetics_GWAS 36631028 hsa-mir-449b Abortion, Spontaneous CONCLUSION: There is a significant association between the risk of RPL and miR-449b/TNF-alpha combination, and therefore, genetic analysis for specific combined genotypes can be an important screening method for RPL in Korean women. +other 36631017 hsa-mir-141 Nasopharyngeal Carcinoma 3p and vimentin in NPC tissues increased significantly. +exosome 36631008 hsa-mir-380 Pulmonary Disease, Chronic Obstructive The expression of miR-380 was significantly elevated in exosomes derived from COPD alveolar macrophages. This process may be involved with abnormal expression of miR-380 in exosomes of COPD alveolar macrophages and down-regulation of CFTR in bronchial epithelial cells. +other 36630972 hsa-mir-99a Familial Hypophosphatemic Rickets MiR-99a-5p might differentiate DR patients from NDR patients and PDR patients from NPDR patients. +other 36630972 hsa-mir-99a Norrie disease The expression of miR-99a-5p was detected in patients with NDR, NPDR, and PDR. MiR-99a-5p might differentiate DR patients from NDR patients and PDR patients from NPDR patients. +lncRNA target 36630972 hsa-mir-99a Duane Retraction Syndrome In conclusion, MiR-99a-5p protected hRMECs against HG damage, and the miR-99a-5p might be a novel target for diagnosis of DR. +other 36629882 hsa-mir-7 Respiratory Distress Syndrome 5p in ARDS biopsies. +lncRNA target 36629518 hsa-mir-6742 Adenocarcinoma of Lung RESULTS: Bioinformatics analysis and dual-luciferase identified FGF8 is the target-gene of miR +other 36629013 hsa-mir-136 Stomach Neoplasms Taken together, our results demonstrated that circ-0000979, as a carcinogenic circRNA, promotes the progression of GC by regulating the miR-136/SP1 pathway. +genetics_overexpression_promote 36628810 hsa-mir-578 Breast Neoplasms Additionally, miR-578 inhibitor or GINS4 overexpression could reverse the inhibitory effect of hsa_circ_0008673 silencing on BC cell progression. CONCLUSION: Hsa_circ_0008673 might promote BC progression via modulating miR-578/GINS4 pathway. +genetics_knock down_promote 36628645 hsa-mir-454 Stomach Neoplasms Long Chain Non-Coding RNA (lncRNA) HOTAIR Knockdown Increases miR3p to Suppress Gastric Cancer Growth by Targeting STAT3/Cyclin D1. +lncRNA target 36628448 hsa-mir-16 Colonic Neoplasms 5p inhibition partly rescued the effects of CERS6-AS1 depletion on CC development. +target gene 36628219 hsa-mir-497 Carcinoma, Hepatocellular Sanguinarine promotes apoptosis of hepatocellular carcinoma cells via regulating the miR-497-5p/CDK4 axis. +genetics_overexpression_promote 36628205 hsa-mir-29a Carcinoma, Endometrioid Overexpression of miR-29a-3p inhibited EC cell growth, migration, and invasion through the regulation of HDAC4, as it is a target of miR-29a-3p. +lncRNA target 36627684 hsa-mir-644a Breast Neoplasms Mechanistically, BCAR4 facilitates breast cancer migration and invasion via the miR-644a-CCR7 axis of the MAPK pathway. BCAR4 promotes ABCB1 expression indirectly by binding to and down-regulating miR-644a to induce chemo-resistance in breast cancer. +lncRNA target 36627670 hsa-mir-1275 Adenocarcinoma of Lung It was transcriptionally repressed by DDP-activated PI3K/AKT/c-Myc signal in LUAD, promoting DDP-acquired chemotherapeutic resistance by regulating miR-1275 to suppress PROCA1/ZFP36L2-induced BCL2 degradation, which led to apoptotic signal reduction. +genetics_overexpression_promote 36627652 hsa-mir-335 Ovarian Neoplasms RESULTS: Overexpression of FOXD3 impaired the proliferation and chemoresistance of OC cells, which was related to the promotion of the miR-335 expression. +exosome 36627634 hsa-mir-218 Colorectal Neoplasms 5p expression in cells and exosomes, inhibiting PTPRR expression, and ultimately activating the Ras/ERK/c-Fos signaling pathway. +genetics_overexpression_promote 36627571 hsa-mir-106a Atherosclerosis CONCLUSION: Overexpression of GASL1 might suppress ox-LDL-induced HUVEC cell viability, apoptosis, and inflammation by regulating miR-106a/LKB1 axis. +lncRNA target 36627545 hsa-mir-1296 Carcinoma, Hepatocellular In conclusion, hsa_circ_0000519 promoted tumor progression and angiogenesis in HCC through the miR-1296/E2F7 axis. +other 36627081 hsa-mir-10a Periapical Periodontitis In addition, miR-10a-5p and miR-891a-5p cooperatively regulate TGFB1 gene expression, and the gene network of this co-regulation is integrated with many pathways in apical periodontitis. +other 36627081 hsa-mir-891a Periapical Periodontitis In addition, miR-10a-5p and miR-891a-5p cooperatively regulate TGFB1 gene expression, and the gene network of this co-regulation is integrated with many pathways in apical periodontitis. +genetics_knock down_promote 36627006 hsa-mir-143 Urinary Bladder Neoplasms 3p inhibition or MSI2 overexpression restored the malignant behaviors of BCa cells induced by circ_644 knockdown or RUNX3 overexpression. +transcription factor target 36626918 hsa-mir-32 Prostatic Neoplasms CONCLUSION: These results indicate that the suppression of miR-32 might offer an auxiliary treatment procedure for addressing the invasion, progression, and metastasis in PCa patients by improving cell apoptosis. +other 36626488 hsa-mir-506 Osteosarcoma Furthermore, immunohistochemistry and quantitative real-time PCR outcomes indicated that the expression level of SLC7A8 and hsa-miR-506 was differentially expressed in lung metastasis OS tissues and non-metastasis tissues. +lncRNA target 36626439 hsa-mir-137 Postoperative Cognitive Complications Taking together, this experiment provide the first experimental and clinical evidence that LncRNA GAS5/miR-137 promoted anesthesia-induced cognitive function to increase inflammatory bodies in patients undergoing lumbar spinal canal decompression, suggesting it may be a biomarker of POCD and a potential therapeutic target for POCD. +genetics_GWAS 36626225 hsa-mir-3 Pulmonary Fibrosis We demonstrate that specific genetic ablation of miR-33 in macrophages protects against bleomycin-induced pulmonary fibrosis. +circRNA target 36626032 hsa-mir-135a Nasopharyngeal Carcinoma Together, our study uncovered the tumor-initiating and pro-metastatic role of circMAN1A2-miR-135a-3p-UBR5-ATMIN axis in NPC regulation that may be a potential therapeutic target for human NPC. +circRNA target 36625877 hsa-mir-766 Intestinal Diseases 3p/Fas axis has potential as a novel therapeutic target for treating intestinal injury in sepsis. +genetics_knock down_suppress 36625260 hsa-mir-498 Colorectal Neoplasms Since hsa_circ_0079480 knockdown inhibited CRC cells malignant behaviors through regulation of the miR-498/ATP5E axis, it can be concluded that hsa_circ_0079480 might have great potential as therapeutic target for CRC. +lncRNA target 36624948 hsa-mir-222 Carcinoma, Renal Cell PYCR1, PYCR2, and PYCRL targeted miR-21, miR-221, and miR-222, resulting in a better prognosis of KIRP. The regulation of microRNAs (miRNAs), including miR-21, miR-221, and miR-222, may prove an important strategy for KIRP treatment. +lncRNA target 36624948 hsa-mir-221 Carcinoma, Renal Cell PYCR1, PYCR2, and PYCRL targeted miR-21, miR-221, and miR-222, resulting in a better prognosis of KIRP. The regulation of microRNAs (miRNAs), including miR-21, miR-221, and miR-222, may prove an important strategy for KIRP treatment. +lncRNA target 36624948 hsa-mir-21 Carcinoma, Renal Cell PYCR1, PYCR2, and PYCRL targeted miR-21, miR-221, and miR-222, resulting in a better prognosis of KIRP. The regulation of microRNAs (miRNAs), including miR-21, miR-221, and miR-222, may prove an important strategy for KIRP treatment. +lncRNA target 36624643 hsa-mir-19b Irritable Bowel Syndrome CONCLUSION: We report five novel microRNA-mRNA regulatory axes in IBS-D pathogenesis and speculated that PIK3R3, negatively regulated by hsa-miR-19b-3p, may regulate NF-kappaB production through the PI3K/Akt pathway, which accounts for the occurrence of clinical symptoms in IBS-D patients. +exosome 36624516 hsa-mir-141 Ovarian Neoplasms CONCLUSIONS: This study uncovers miR-141 as an OvCa-derived exosomal microRNA mediating the tumor-stroma interactions and the formation of tumor-promoting stromal niche through activating YAP1/GROalpha/CXCRs signaling cascade, providing new insight into therapy for OvCa patients with peritoneal metastases. +genetics_overexpression_promote 36624091 hsa-mir-488 Stomach Neoplasms Overexpression of circPOFUT1 enhanced autophagy-associated chemoresistance of GC cells in vivo, but it was inhibited by overexpression of miR +lncRNA target 36623778 hsa-mir-155 Irritable Bowel Syndrome CONCLUSIONS: Decreased colonic COMT in PI-IBS-D patients drives abdominal pain phenotypes via the COMT/miR-155/TNF-alpha axis. +circulation_biomarker_prognosis_up 36623770 hsa-mir-98 Carcinoma, Hepatocellular 5p was significantly decreased, while HBEGF expression was significantly increased in the serum of HCC patients compared with the control group. +other 36623676 hsa-mir-125b Aortic Aneurysm, Abdominal In conclusion, AAA patients might be benefit from EVAR based on various pathways and some molecules, such as miR-125b and SATB1-AS1, related with shear stress. +exosome 36623674 hsa-mir-125a Carcinoma, Non-Small-Cell Lung CONCLUSIONS: Exosomal miR-125a-3p is a potential predictor of response to anti-PD-1/PD-L1 therapy in advanced NSCLC patients with low PD-L1 expression. +genetics_overexpression_promote 36622742 hsa-mir-181a Polycystic Ovary Syndrome CDKN2B-AS1 is overexpressed in PCOS and may sponge miR-181a to promote granulosa cell proliferation. +transcription factor target 36622663 hsa-mir-361 Breast Neoplasms Together, these studies identify miR3p inhibitor as a potential new treatment for drug-responsive and -resistant advanced BC. +other 36622069 hsa-mir-542 Mesenteric Ischemia Exogenous S1P analogs administered in vivo protect murine intestinal barrier from damage due to mesenteric ischemia reperfusion, and damaged intestinal tissue had increased levels of miR5p. +target gene 36621840 hsa-mir-140 Breast Neoplasms Doxorubicin resistance in breast cancer xenografts and cell lines can be counterweighted by microRNA-140-3p, through PD-L1 suppression. +lncRNA target 36621784 hsa-mir-155 Arthritis, Rheumatoid Objective To investigate the expression regulation of autophagy-related genes(ATG)and the mechanism of autophagy in rheumatoid arthritis(RA).Methods The differentially expressed genes(DEG)of RA were identified from GSE55235 and GSE55457,on the basis of which the differentially expressed autophagy-related genes(DE-ATG)were selected from the Human Autophagy Database.STRING 11.0 and GeneMANIA were used to establish protein-protein interaction networks.Further,the transcription factor-gene-miRNA co-expression network was established via NetworkAnalyst and Cytoscape.Finally,receiver operating characteristic(ROC)curve and DrugBank were employed to evaluate the efficacy of the predicted biomarkers and the performance of drugs targeting DE-ATG.GraphPad Prism 8.2.1 and R 4.0.3 were used for statistical analysis and graphics.Results A total of 485 DEG were enriched in signaling pathways such as T cell activation,hormone regulation,osteoclast differentiation,RA,and chemokines.Eleven DE-ATG regulated the expression of RUNX1,TP53,SOX2,and hsa-mir5p in synovial tissues of RA patients and were involved in the response to environmental factors such as 2,3,7,8-tetrachlorodibenzodioxin and silicon dioxide.The ROC curve analysis identified the DE-ATG with good sensitivity and specificity,such as MYC,MAPK8,CDKN1A,and TNFSF10,which can be used to distinguish certain phenotypes and serve as novel biomarkers for RA.Conclusions In RA,down-regulated DE-ATG expression may promote apoptosis and lysis of chondrocytes.The identified novel biomarkers provides new ideas and methods for diagnosing and treating RA.The establishment of transcription factor-miRNA-gene co-expression network provides direct evidence for dissecting synovial inflammation and articular cartilage destruction. +target gene 36620931 hsa-mir-433 Colorectal Neoplasms LncRNA IGFL2-AS1 as a ceRNA Promotes HCT116 Cell Malignant Proliferation via the miR-433-3p/PAK4 Axis. +other 36620850 hsa-mir-128a Glioblastoma PURPOSE: The purpose is to evaluate the expression of the genes EGFR, PTEN, MGMT, and IDH1/2, and microRNAs miR-181b, miR-145, miR-149, and miR-128a in adhered cells (AC) and neurospheres (NS) from cell lines (T98G and U343) submitted to temozolomide (TMZ) and ionizing radiation (IR). The expression of miRNAs results as a) AC (U343) expressed more miR-181b after TMZ, IR, and TMZ IR; and miR-128a improved after TMZ, IR, and TMZ IR; b) NS (T98G) after TMZ IR expressed: miR-181b; miR-149; miR-145 and miR-128a; c) NS (U343) after IR huge expressed miR-149 and miR-145. +other 36620850 hsa-mir-149 Glioblastoma PURPOSE: The purpose is to evaluate the expression of the genes EGFR, PTEN, MGMT, and IDH1/2, and microRNAs miR-181b, miR-145, miR-149, and miR-128a in adhered cells (AC) and neurospheres (NS) from cell lines (T98G and U343) submitted to temozolomide (TMZ) and ionizing radiation (IR). The expression of miRNAs results as a) AC (U343) expressed more miR-181b after TMZ, IR, and TMZ IR; and miR-128a improved after TMZ, IR, and TMZ IR; b) NS (T98G) after TMZ IR expressed: miR-181b; miR-149; miR-145 and miR-128a; c) NS (U343) after IR huge expressed miR-149 and miR-145. +other 36620850 hsa-mir-145 Glioblastoma PURPOSE: The purpose is to evaluate the expression of the genes EGFR, PTEN, MGMT, and IDH1/2, and microRNAs miR-181b, miR-145, miR-149, and miR-128a in adhered cells (AC) and neurospheres (NS) from cell lines (T98G and U343) submitted to temozolomide (TMZ) and ionizing radiation (IR). The expression of miRNAs results as a) AC (U343) expressed more miR-181b after TMZ, IR, and TMZ IR; and miR-128a improved after TMZ, IR, and TMZ IR; b) NS (T98G) after TMZ IR expressed: miR-181b; miR-149; miR-145 and miR-128a; c) NS (U343) after IR huge expressed miR-149 and miR-145. +other 36620850 hsa-mir-181b Glioblastoma PURPOSE: The purpose is to evaluate the expression of the genes EGFR, PTEN, MGMT, and IDH1/2, and microRNAs miR-181b, miR-145, miR-149, and miR-128a in adhered cells (AC) and neurospheres (NS) from cell lines (T98G and U343) submitted to temozolomide (TMZ) and ionizing radiation (IR). The expression of miRNAs results as a) AC (U343) expressed more miR-181b after TMZ, IR, and TMZ IR; and miR-128a improved after TMZ, IR, and TMZ IR; b) NS (T98G) after TMZ IR expressed: miR-181b; miR-149; miR-145 and miR-128a; c) NS (U343) after IR huge expressed miR-149 and miR-145. +transcription factor target 36620589 hsa-mir-194 Gastrointestinal Neoplasms Our finding highlights that miR-194 exerts a tumor-suppressive role in digestive system cancers by targeting ATP6V1F, PPP1R14B, BTF3L4 and SLC7A5. +target gene 36620570 hsa-mir-7705 Stomach Neoplasms hsa_circ_0061276 may be a new biomarker for gastric cancer. The tumor suppressor role of hsa_circ_0061276 on gastric cancer likely occurs through a sponge effect on miRNAs such as hsa-miR-7705. +circulation_biomarker_diagnosis_up 36620222 hsa-mir-486 Cerebral Palsy Interestingly, miR-486 was upregulated 2-fold in the EVs of CP vs. TD both at baseline and after exercise. Our data suggest that circulating miR-486 transported by EVs is elevated in individuals with CP and that miR-486 alters the transcriptome of myoblasts affecting both ECM- and sarcomerogenesis-related genes, providing a link to the skeletal muscle alterations observed in individuals with CP. +lncRNA target 36619898 hsa-mir-197 Lymphoma, B-Cell 5p, and miR-650 were revealed to be targeting TRAF5 and participating in NF-kappaB signaling pathway and might impact the apoptosis and signal transduction of DLBCL. +exosome 36619870 hsa-mir-191 Uveal melanoma Additionally, the comparison of miRNA expression levels in exosomes derived from UM patients with those derived from healthy donors revealed that hsa-miR +lncRNA target 36619232 hsa-mir-122 Carcinoma, Hepatocellular Rescue experiments showed that RPPH1 acted as a competing endogenous RNA (ceRNA) by sponging miR-122 in HCC cells. Our study demonstrates for the first time that RPPH1 promotes HCC progression via the miR-122/Wnt1/beta-catenin axis, which may represent a valuable therapeutic target for patients with HCC. +transcription factor target 36619199 hsa-mir-146a Pulmonary Disease, Chronic Obstructive The present study aimed to observe the effects of ECC-BYF III in a COPD rat model and dissect its potential mechanisms in regulating mucus hypersecretion via the miR-146a-5p/epidermal growth factor receptor (EGFR)/MEK/ERK pathway. The protective effect of ECC-BYF III in reducing airway mucus hypersecretion in COPD may involve the miR-146a-5p/EGFR/MEK/ERK pathway. +target gene 36618816 hsa-mir-363 Lymphoma, T-Cell MiR-363 suppresses the tumor growth of natural killer/T-cell lymphoma via the SIRT6/PI3K/AKT axis. +lncRNA target 36618771 hsa-let-7a Carcinoma, Hepatocellular Chol-let-7a had some off-target effects, such as mild acute hepatitis-like inflammation and non-specific drug-induced kidney injury. +genetics_knock down_promote 36618768 hsa-mir-576 Thyroid Cancer, Papillary 5p was significantly overexpressed in PTC tissues and TPC-1 cells. +circulation_biomarker_diagnosis_ns 36618534 hsa-mir-15b Obesity Effects of Two Different School-Based Training on Serum miR15b Expression and BACKGROUND: Some circulating microRNAs, such as miR15b, are predictors of diseases associated with adulthood obesity. This study aimed to evaluate the effect of two selected school-based and high-intensity interval training (HIT) on miR15b expression and lipid profile of obese adolescents. +circulation_biomarker_diagnosis_ns 36618355 hsa-let-7i Malaria We provide evidence of a significant correlation between miR-451a and let-7i-5p-loaded circulating exosomes in plasmodium-infected patients with reported clinical benchmarks of malaria-severity (e.g., Hemoglobin (Hb) levels, white blood cell counts). Based on these findings, we propose a model in which increased levels of exosomal miR-451a and let-7i-5p in Plasmodium-infected individuals will attenuate inflammatory responses to free-heme and parasite-derived products. +circulation_biomarker_diagnosis_ns 36618355 hsa-mir-451a Malaria We provide evidence of a significant correlation between miR-451a and let-7i-5p-loaded circulating exosomes in plasmodium-infected patients with reported clinical benchmarks of malaria-severity (e.g., Hemoglobin (Hb) levels, white blood cell counts). Based on these findings, we propose a model in which increased levels of exosomal miR-451a and let-7i-5p in Plasmodium-infected individuals will attenuate inflammatory responses to free-heme and parasite-derived products. +other 36618264 hsa-mir-20 Hyperglycemia In conclusion, in DM-induced cardiac injury, miR-320 and CD36 mutually enhance each other's expression, leading to a positive feedback loop and a sustained hyperlipidemic state in the heart. +other 36618263 hsa-mir-7 Brain Ischemia Overall, our findings imply that CDR1as reconstitution is neuroprotective after stroke, probably by protecting miR-7 and preventing alpha-Syn-mediated neuronal death. +genetics_knock down_promote 36617978 hsa-mir-1205 Carcinoma, Hepatocellular Furthermore, CSNK2B significantly promoted HCC cell proliferation, and CSNK2B overexpression or knockdown attenuated the effects of miR-1205 overexpression or inhibition on HCC cell viability, respectively. +other 36617839 hsa-mir-34a Asthma CONCLUSION: LncRNA THRIL negatively relates to miR-34a and miR-125b, correlate with inflammatory cytokines, and exacerbated the risk and severity of childhood asthma, indicating their potential as biomarkers for childhood asthma management. +other 36617839 hsa-mir-125b Asthma CONCLUSION: LncRNA THRIL negatively relates to miR-34a and miR-125b, correlate with inflammatory cytokines, and exacerbated the risk and severity of childhood asthma, indicating their potential as biomarkers for childhood asthma management. +lncRNA target 36617735 hsa-mir-513a Urinary Bladder Neoplasms Mechanistically, circHGS functions as a sponge of miR-513a-5p to elevate VEGFC expression and activate the AKT/mTOR signaling pathway, ultimately promoting BCa progression. Our findings indicated that circHGS promotes BCa progression via the miR-513a-5p/VEGFC/AKT/mTOR pathway and can be a promising therapeutic target of BCa. +lncRNA target 36617513 hsa-mir-578 Breast Neoplasms Circ_0048764 depletion suppressed the proliferative, migrative, and invasive abilities of BC cells, which was rescued by transfection of miR-578 inhibitors. +transcription factor target 36617469 hsa-mir-10b Adenocarcinoma of Lung RESULTS: The expression of miR-10b was up-regulated in non-small cell lung cancer, and miR-10b inhibitor could inhibit the proliferation of A549 cell. +other 36617199 hsa-mir-93 Endometriosis CONCLUSION: VEGFA and MMP3 expression levels trended to be increased in both eutopic and ectopic endometrial tissues of endometriosis women, while down-regulation of miR-93 might be involved in the alteration of VEGFA and MMP3 in endometriosis. +target gene 36615779 hsa-mir-34a Non-alcoholic Fatty Liver Disease Exercise-Induced ADAR2 Protects against Nonalcoholic Fatty Liver Disease through miR-34a. +circulation_biomarker_diagnosis_ns 36615122 hsa-mir-342 Breast Neoplasms Furthermore, we examined three plasma miRNAs in BC patients (n = 108) and healthy subjects (n = 103) by RT-PCR, namely, hsa-miR +other 36615083 hsa-mir-200c COVID-19 Here, we investigated miRNA-200c as a potential marker for the prediction of the severity of COVID-19 to preventively initiate and personalize therapeutic interventions in the future. Our study provides the basis for further evaluation of miRNA-200c as a predictive biomarker for the progress of COVID-19. +other 36614208 hsa-mir-15a Memory Disorders This study investigated the potential of Dex to mitigate MTX-induced neurotoxicity and memory impairment in rats and the possible role of the miR-15a/ROCK-1/ERK1/2/CREB/BDNF pathway. +lncRNA target 36614110 hsa-mir-200c Esophageal Achalasia Taking into account our previous results on the downexpression of miR-200c-3p in tissues of patients with achalasia correlated with an increased expression of PRKG1, SULF1, and SYDE1 genes, our aim was to explore the unknown biological interaction between these genes and human miR-200c-3p and if this relation could unravel their functional role in the etiology of achalasia. Our study provides, for the first time, functional evidence about the PRKG1 gene as a direct target and SULF1 and SYDE1 as potential indirect substrates of miR-200c-3p and suggests the involvement of NO/cGMP/PKG signaling in the pathogenesis of achalasia. +genetics_overexpression_suppress 36614061 hsa-mir-423 Prostatic Neoplasms Pathway enrichment analysis revealed that stable overexpression of miR +circulation_biomarker_diagnosis_ns 36613908 hsa-mir-101 Ovarian Neoplasms The relative levels of miR-24 and miR-101 in plasma exosomes of HFs were significantly higher than in plasma exosomes of OC patients, while the levels of these microRNAs in exosomes from plasma and ascites of ill females showed no difference. +other 36613808 hsa-mir-221 Breast Neoplasms Furthermore, the co-reduction in oncogenic miRNA levels (miR-9 and miR-221) was a result of the down-modulation in AGO2 in breast cancer cells in vitro. +other 36613808 hsa-mir-9 Breast Neoplasms Furthermore, the co-reduction in oncogenic miRNA levels (miR-9 and miR-221) was a result of the down-modulation in AGO2 in breast cancer cells in vitro. +genetics_GWAS 36613718 hsa-mir-155 Mycosis Fungoides The purpose of this study is to evaluate the plasma levels of miR-146a and miR-155 in MF patients and to investigate their association with SNPs of their genes. +other 36613642 hsa-mir-142 Carcinoma, Non-Small-Cell Lung 5p, miR-199b-5p, miR-199a-3p, miR-199b-5p, and miR-199a-5p). +other 36613642 hsa-mir-219a-2 Carcinoma, Non-Small-Cell Lung 5p, miR-199b-5p, miR-199a-3p, miR-199b-5p, and miR-199a-5p). +other 36613642 hsa-mir-199b Carcinoma, Non-Small-Cell Lung 5p, miR-199b-5p, miR-199a-3p, miR-199b-5p, and miR-199a-5p). +other 36613642 hsa-mir-219a Carcinoma, Non-Small-Cell Lung 5p, miR-199b-5p, miR-199a-3p, miR-199b-5p, and miR-199a-5p). +other 36613642 hsa-mir-199a Carcinoma, Non-Small-Cell Lung 5p, miR-199b-5p, miR-199a-3p, miR-199b-5p, and miR-199a-5p). +other 36613642 hsa-mir-9 Carcinoma, Non-Small-Cell Lung 5p, miR-199b-5p, miR-199a-3p, miR-199b-5p, and miR-199a-5p). +other 36613642 hsa-mir-124 Carcinoma, Non-Small-Cell Lung 5p, miR-199b-5p, miR-199a-3p, miR-199b-5p, and miR-199a-5p). +other 36613642 hsa-mir-129-2 Carcinoma, Non-Small-Cell Lung 5p, miR-199b-5p, miR-199a-3p, miR-199b-5p, and miR-199a-5p). +circulation_biomarker_diagnosis_ns 36613584 hsa-mir-223 Obesity 5p/miRNA-4454/miRNA in circulating exosomes obtained from the same cohort of obese (O, n = 22) and normal-weight adolescents (N, n = 22). +circulation_biomarker_diagnosis_ns 36613584 hsa-mir-4454 Obesity 5p/miRNA-4454/miRNA in circulating exosomes obtained from the same cohort of obese (O, n = 22) and normal-weight adolescents (N, n = 22). +circulation_biomarker_diagnosis_ns 36613584 hsa-mir-142 Obesity 5p/miRNA-4454/miRNA in circulating exosomes obtained from the same cohort of obese (O, n = 22) and normal-weight adolescents (N, n = 22). +other 36613546 hsa-mir-500a Ischemic Attack, Transient 3p were upregulated, while hsa-miR-500a-3p and -206 were downregulated in AIS patients compared to TIA patients. +other 36613546 hsa-mir-500a Ischemic Stroke 3p were upregulated, while hsa-miR-500a-3p and -206 were downregulated in AIS patients compared to TIA patients. +other 36613546 hsa-mir-206 Ischemic Stroke 3p were upregulated, while hsa-miR-500a-3p and -206 were downregulated in AIS patients compared to TIA patients. +other 36613546 hsa-mir-206 Ischemic Attack, Transient 3p were upregulated, while hsa-miR-500a-3p and -206 were downregulated in AIS patients compared to TIA patients. +other 36613546 hsa-mir-548c Ischemic Attack, Transient 3p were upregulated, while hsa-miR-500a-3p and -206 were downregulated in AIS patients compared to TIA patients. +other 36613546 hsa-mir-548c Ischemic Stroke 3p were upregulated, while hsa-miR-500a-3p and -206 were downregulated in AIS patients compared to TIA patients. +other 36613525 hsa-mir-375 Non-alcoholic Fatty Liver Disease Furthermore, deltaT3 has more pronounced effects than alphaTF in reducing miR-375 and miR-34a, which are linked to regulation of inflammation and apoptosis. +other 36613525 hsa-mir-34a Non-alcoholic Fatty Liver Disease Furthermore, deltaT3 has more pronounced effects than alphaTF in reducing miR-375 and miR-34a, which are linked to regulation of inflammation and apoptosis. +other 36612284 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck MiR-21 did not show any variation among groups; miR-27b was under-expressed in dysplastic lesions (p = 0.046); miR-181b was upregulated in high-grade dysplasia (p = 0.006), increasing with the degree of dysplasia, and decreasing in OSCCs. +other 36612284 hsa-mir-181b Squamous Cell Carcinoma of Head and Neck (4) Conclusions: Salivary miR-27b and miR-181b could be promising biomarkers for oral dysplasia. +other 36612284 hsa-mir-27b Squamous Cell Carcinoma of Head and Neck (4) Conclusions: Salivary miR-27b and miR-181b could be promising biomarkers for oral dysplasia. +circulation_biomarker_diagnosis_ns 36612201 hsa-let-7d Carcinoma, Hepatocellular In our Chinese cohorts, three serum-exosome-derived miRNAs (miR +circulation_biomarker_diagnosis_ns 36612201 hsa-mir-122 Carcinoma, Hepatocellular In our Chinese cohorts, three serum-exosome-derived miRNAs (miR +lncRNA target 36612120 hsa-mir-545 Carcinoma, Renal Cell Mechanistically, we found that circ-PRKCI promoted the proliferation of RCC via the miR3p/CCND1 signaling pathway. +genetics_knock down_promote 36611966 hsa-mir-21 Carcinoma, Renal Cell 5p inhibitor suppressed the cell growth and cell invasion of ACHN and OSRC-2 cells, which could be compensated by FDX1 knockdown, reinforcing the functional linkage between miR +transcription factor target 36611916 hsa-mir-21 proliferative diabetic retinopathy This study identified miR-125 and miR-21 as potential targets for further functional analysis regarding their putative role in the pathogenesis of PDR. +transcription factor target 36611916 hsa-mir-125 proliferative diabetic retinopathy This study identified miR-125 and miR-21 as potential targets for further functional analysis regarding their putative role in the pathogenesis of PDR. +other 36611869 hsa-mir-497 Parkinson Disease 5p in PD contributes to enhanced progressive neurodegeneration of PD patients. +genetics_overexpression_suppress 36611865 hsa-mir-7 Pancreatitis The overexpressed SNHG11/miR +transcription factor target 36611425 hsa-mir-146a COVID-19 We found here that CDKN1B gen is a shared target of miR-146a, miR +transcription factor target 36611425 hsa-mir-155 COVID-19 We found here that CDKN1B gen is a shared target of miR-146a, miR +transcription factor target 36611425 hsa-mir-221 COVID-19 We found here that CDKN1B gen is a shared target of miR-146a, miR +circRNA target 36611218 hsa-mir-184 Osteosarcoma 5p/EGFR pathway, indicating that circEMB may serve as a therapeutic target for OSA. +other 36611161 hsa-mir-15b Pulmonary Fibrosis In addition, increased expression of miRNA15b was identified with decreased expression of Smurf2 mRNA in PF models. +other 36610331 hsa-mir-197 Osteoarthritis RESULTS: OA tissues and model cells had higher abundance of circ_0003800 and SOX5, while miR3p content was lower. +transcription factor target 36610147 hsa-mir-195 Ovarian Neoplasms CONCLUSION: Both in vitro and in vivo data demonstrated that TSN could reduce DDP resistance in OC through regulating the miR-195/ERK/beta-catenin pathway, highlighting the potential of TSN as an effective agent for favoring overcoming clinical DDP resistance in OC. +circulation_biomarker_diagnosis_ns 36609569 hsa-mir-6750 Nasopharyngeal Carcinoma Here, we detected miR-6750, the precise molecular function of which was largely unknown, was significantly enriched in serum-SEVs from normal volunteers vs. patients with nasopharyngeal carcinoma (NPC). +circulation_biomarker_diagnosis_down 36609531 hsa-mir-339 Acute Kidney Injury 5p expression was downregulated in the blood of septic AKI patients, and miR +exosome 36609437 hsa-mir-598 Carcinoma, Non-Small-Cell Lung In the present study, we sought to define the role of mesenchymal stem cells (MSCs)-derived extracellular vesicles (EVs) containing miR-598 in NSCLC. +lncRNA target 36609391 hsa-mir-23b Esophageal Neoplasms Hsa_circ_0021727 promoted ESCC progression by activating TAB1/NFkappaB pathway by sponging miR-23b-5p. In short, hsa_circ_0021727 promotes ESCC progression by targeting miR-23b-5p to activate the TAB1/NFkappaB pathway. +lncRNA target 36609253 hsa-mir-141 Intervertebral Disc Degeneration CONCLUSION: PLGA microspheres coloaded with TGF-beta1 and anti-miR-141 can reverse IDD by inhibiting the degeneration of NPCs. +other 36609154 hsa-mir-129 Memory Disorders BACKGROUND: SAHA was reported to enhance the expression of miR5p, which was predicted to bind to 3' UTR of CASP-6, a gene playing crucial roles in the pathogenesis of memory impairment. +transcription factor target 36608839 hsa-mir-155 Hypoxia-Ischemia, Brain Together, our results demonstrated that miR-155 exerted a negative effect in HIBD by targeting SIRT1, which could contribute to the treatment of neonatal patients with hypoxic-ischemic brain damage. +lncRNA target 36608833 hsa-mir-940 Ischemic Stroke CONCLUSION: Depletion of circ_0006459 protected human brain microvascular endothelial cells from oxygen-glucose deprivation-induced damage through miR-940/FOXJ2 pathway, providing a promising therapeutic target for ischemic stroke. +circRNA target 36608542 hsa-mir-384 Carcinoma, Renal Cell miR-384 inhibitor transfection attenuated the inhibiting impacts of circ_0101692 silencing on ccRCC cell progression. +genetics_knock down_suppress 36608447 hsa-mir-373 Osteoarthritis CONCLUSION: Our data confirmed that circ_0001721 knockdown alleviated IL-1beta-induced chondrocyte injury by miR3p/CXCR4 axis, which suggested that circ_0001721 might be a potential therapeutic target for OA. +genetics_overexpression_suppress 36607951 hsa-mir-154 Carcinoma, Pancreatic Ductal In rescue assays, KPNA4 overexpression or miR +other 36607643 hsa-mir-872 Spinal Cord Ischemia In conclusion, SCIRI in vivo and OGD/R in vitro stimulated the miR5p/FOXO3a/beta-catenin-TCF4 pathway, thereby promoting NSC proliferation. +lncRNA target 36607481 hsa-mir-195 Carcinoma, Hepatocellular 5p targeted CDK1 and repressed synthesis of new DNA in HCC cells, thus restraining HCC cell proliferation. +genetics_overexpression_promote 36607163 hsa-mir-612 Nasopharyngeal Carcinoma overexpression-induced repression of the migration, adhesion, and proliferation of NPC cells via the activation of the PI3K/AKT pathway. +lncRNA target 36606668 hsa-mir-148a Uterine Cervical Neoplasms The Human papillomavirus E6 protein might reduce the expression of miR-148a-3p, relieve the inhibitory effect of miR-148a-3p on LIPG expression, and promote the progression of cervical cancer through the phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B/mechanistic target of rapamycin kinase signalling pathway.IMPACT STATEMENTWhat is already known on this subject? LIPG provides lipid precursors, suggesting that it might function in the metabolism of carcinoma cellsWhat do the results of this study add? LIPG might be regulated by HPV16 E6/miR-148a-3p and promote cervical carcinoma progression via the PI3K/AKT/mTOR signalling pathway.What are the implications of these finding for clinical practice and/or further research? The results indicated that novel treatment and diagnosis strategies for cervical carcinoma could be developed related to LIPG. +other 36606643 hsa-let-7i Ischemic Stroke We selected five miRNAs (miR-17, miR-93, miR-450, miR-629, and let-7i) related to atherosclerosis based on a literature review. CONCLUSIONS: The expression level of let-7i was independently related to arterial stiffness in patients with cerebral infarction, suggesting that it plays a pathophysiological role in atherosclerosis. +lncRNA target 36606578 hsa-mir-145 Thyroid Cancer, Papillary 3p that targeted TGFBR2 and USP15, both of which synergistically promoted lymphangiogenesis and lymphatic metastasis of PTC. +other 36606461 hsa-mir-144 Obesity Bivariate GWAS analysis found MIR144 gene and its related biological pathways may influence obesity and lipid levels. +circulation_biomarker_diagnosis_down 36606278 hsa-mir-29b Sarcopenia Moreover, we used real-time RT-PCR to measure the abundance of the CVRF-related miRNAs in the plasma of a cohort of 93 control and sarcopenia individuals, including miR-29b, miR-181a, and miR-494. We found that plasma miR-29b levels were significantly down-regulated in response to sarcopenia in the elderly with CVRF. +other 36606191 hsa-mir-143 Prostatic Neoplasms miR-143 mediates abiraterone acetate resistance by regulating the JNK/Bcl-2 signaling pathway in prostate cancer. +other 36605803 hsa-mir-146a Diabetes Mellitus Our previous studies have shown the ability of a cerium oxide nanoparticle (CNP) formulation conjugated with the anti-inflammatory microRNA miR146a (CNP-miR146a) to enhance the healing of diabetic wounds. Comparison with miR146a conjugated gold (bioactive, metal) and silica (bioinert, oxide) nanoparticles (AuNPs and SiO(2)NPs) was performed in the presence of H(2)O(2), as an analogue to the high levels of ROS present in the diabetic wound environment. +target gene 36605483 hsa-mir-22 Liver Neoplasms Long noncoding RNA DSCR8 promotes the proliferation of liver cancer cells and inhibits apoptosis via the miR-22-3p/ARPC5 Axis. +genetics_knock down_promote 36605481 hsa-mir-653 Colorectal Neoplasms Moreover, miR-653 served as carcinoma-promoting gene via targeting KLF6, and circSETD3 knockdown significantly reversed the inhibitory effect of KLF6 overexpression on CRC cells. +circulation_biomarker_diagnosis_ns 36604945 hsa-mir-181a Osteoporosis RESULTS: miR-181a-5p was highly expressed in the serum of osteoporosis patients. +lncRNA target 36604807 hsa-mir-486 Atrial Fibrillation 5p expression and had a potential targeting relationship with miR +lncRNA target 36604774 hsa-mir-3158 Migraine Disorders 5p via CNVs to modulate the mechanism of pain. +lncRNA target 36604774 hsa-mir-548e Migraine Disorders CNVs, the Cholinergic Receptor Nicotinic Alpha 7 Subunit (CHRNA7) gene, and expression of gene-targeting miRNAs (hsa-miR-548e-5p and hsa-miR5p) in migraineurs (n = 102; with aura, n = 43; without aura, n = 59) and non-migraines (n = 120) aged 15-60 years, comparative, case-control study was conducted. +lncRNA target 36604721 hsa-mir-340 Osteosarcoma CONCLUSION: FGF23 promotes osteosarcoma cell proliferation, migration and invasion by targeting miR5p gene expression. +circulation_biomarker_diagnosis_up 36604580 hsa-mir-484 Graves Ophthalmopathy 5p differed significantly between the active and inactive TED groups, suggesting that these miRNAs could serve as circulating biomarkers of TED activity, however, these findings need to be validated in further studies. +circulation_biomarker_diagnosis_up 36604580 hsa-mir-192 Graves Ophthalmopathy 5p differed significantly between the active and inactive TED groups, suggesting that these miRNAs could serve as circulating biomarkers of TED activity, however, these findings need to be validated in further studies. +target gene 36604405 hsa-mir-486 Thyroid Neoplasms Circ_0124055 promotes the progression of thyroid cancer cells through the miR-486-3p/MTA1 axis. +lncRNA target 36604379 hsa-mir-8881 Charcot-Marie-Tooth disease type 1B The aim of this study was to investigate the effects of lncRNA34977 on the proliferation, migration, invasion, and apoptosis of canine mammary tumor (CMT) cells through the regulation of miR-8881/ELAVL4 expression. Our study shows that lncRNA34977 promotes the proliferation, migration, and invasion and suppresses the apoptosis of CMT cells by regulating the expression of miR-8881/ELAVL4. +other 36603835 hsa-mir-223 Coronary Artery Disease 3p expression to traditional cardiovascular risk factors may improve prediction of cardiovascular events, particularly ST. +transcription factor target 36603462 hsa-mir-342 Atrial Premature Complexes 3p in contributing NHT-R by targeting CREB5 in PCa. +transcription factor target 36603462 hsa-mir-150 Atrial Premature Complexes 3p in contributing NHT-R by targeting CREB5 in PCa. +transcription factor target 36603462 hsa-mir-142 Atrial Premature Complexes 3p in contributing NHT-R by targeting CREB5 in PCa. +other 36603443 hsa-mir-122 Breast Neoplasms In the perusal, a novel electrochemical biosensor amplified with hierarchical flower-like gold, poly (n-butyl acrylate), and MXene (AuHFGNs/PnBA-MXene) nanocomposite and activated by highly special antisense ssDNA (single-stranded DNA) provide a promising alternative for miRNA-122 detection as a biomarker of breast cancer. +lncRNA target 36603340 hsa-mir-200c Retinoblastoma Our results demonstrate that miRNA-200c-3p inhibits EMT progression through the Wnt16/beta-catenin/ZEB1/E-cadherin axis, and the ZEB1 silencing response shows that miR-200c-3p regulates ZEB1-mediated EMT in retinoblastoma. +lncRNA target 36602696 hsa-mir-124 Stomach Neoplasms HRCT1, negatively regulated by miR3p, may be a potential therapeutic target for patients with gastric cancer. +lncRNA target 36602629 hsa-mir-143 Diabetes Mellitus, Type 2 Collectively, lncRNA UCA1 inhibited mitochondrial dysfunction of skeletal muscle in T2DM by sequestering miR3p away from FGF21, therefore providing a potential therapeutic target for alleviating mitochondrial dysfunction of skeletal muscle in T2DM. +lncRNA target 36602629 hsa-mir-143 Mitochondrial Diseases 3p away from FGF21, therefore providing a potential therapeutic target for alleviating mitochondrial dysfunction of skeletal muscle in T2DM. +genetics_overexpression_promote 36602424 hsa-mir-25 Carcinoma, Non-Small-Cell Lung Accordingly, overexpression of circ_BLNK improved DDP sensitivity of NSCLC cells via miR +lncRNA target 36602216 hsa-mir-122 Carcinoma, Hepatocellular Our data indicated an interaction between miRNA-122 and TGF-b1, regulated gene expression and recommended the use of these parameters as noninvasive predictive biomarkers and therapeutic targets for HCV induced liver cirrhosis and HCC. +lncRNA target 36602216 hsa-mir-122 Hepatitis C Our data indicated an interaction between miRNA-122 and TGF-b1, regulated gene expression and recommended the use of these parameters as noninvasive predictive biomarkers and therapeutic targets for HCV induced liver cirrhosis and HCC. +circulation_biomarker_diagnosis_up 36601739 hsa-mir-92a Coronary Restenosis The serum miR92a expression levels were significantly higher in patients with instent restenosis (ISR) compared with those in patients without ISR, whereas KLF4 expression was significantly reduced in the nonISR group. +lncRNA target 36601671 hsa-mir-130a Inflammation It was demonstrated that Pue induced the expression of miR-130a-5p, which suppressed the activity of HMGB2/NF-kappaB, contributing to the attenuation of infarct heart tissues. +other 36601516 hsa-mir-7 Endometrial Hyperplasia CONCLUSION: We concluded that miR5p attenuates vascular smooth muscle cell migration and intimal hyperplasia after vascular injury by NF-kB signaling. +transcription factor target 36600989 hsa-mir-193b Carcinoma, Hepatocellular Enforced CDK1 expression attenuated miR-193b-3p-modulated suppressive actions on HCC cell proliferation and migration. +genetics_overexpression_promote 36600625 hsa-mir-375 Uterine Cervical Neoplasms Besides, miR-375 was revealed to be a downstream target of circ_0002762, and miR-375 overexpression counteracted the promoting effects of circ_0002762 overexpression on CC cell viability and migration. +exosome 36600320 hsa-mir-124 Carcinoma, Non-Small-Cell Lung 3p significantly suppressed metastasis through extracellular exosome transport and intracellular PI3K/AKT signaling. +target gene 36599973 hsa-mir-206 Osteosarcoma LncSNHG14 promotes nutlin3a resistance by inhibiting ferroptosis via the miR-206 /SLC7A11 axis in osteosarcoma cells. +target gene 36599932 hsa-mir-144 Liver Neoplasms ADAR1-dependent miR-3144-3p editing simultaneously induces MSI2 expression and suppresses SLC38A4 expression in liver cancer. +genetics_overexpression_suppress 36599649 hsa-mir-139 Colonic Neoplasms 3p silencing or CDK16 overexpression abolished the inhibitory effects of baicalin on colon cancer proliferation. +circRNA target 36598961 hsa-mir-582 Leukemia, Myeloid, Acute CONCLUSION: Our findings identify that suppression of circ_0003256 impedes the malignant behaviors of pediatric AML cells by regulating PRKACB expression by competing for shared miR3p. +other 36598779 hsa-mir-574 Colorectal Neoplasms 3p, and miRNA-27a may serve as better noninvasive biomarkers with higher combined sensitivity for early diagnosis of CRC than individual detection of miRNAs. +other 36598779 hsa-mir-133a Colorectal Neoplasms 3p, and miRNA-27a may serve as better noninvasive biomarkers with higher combined sensitivity for early diagnosis of CRC than individual detection of miRNAs. +other 36598779 hsa-mir-27a Colorectal Neoplasms 3p, and miRNA-27a may serve as better noninvasive biomarkers with higher combined sensitivity for early diagnosis of CRC than individual detection of miRNAs. +genetics_overexpression_promote 36598700 hsa-mir-342 Pre-Eclampsia 5p antagomir, and overexpressing PDCD4 (oe-PDCD4) vector into the placenta on the 16th day of pregnancy. +epigenetics 36598670 hsa-mir-129-2 Carcinoma, Non-Small-Cell Lung A high level of methylation of the MIR137 and MIR1258 genes was shown for adenocarcinoma and MIR339, MIR129-2, and MIR124-2 for squamous cell carcinoma. +epigenetics 36598670 hsa-mir-1258 Carcinoma, Non-Small-Cell Lung A high level of methylation of the MIR137 and MIR1258 genes was shown for adenocarcinoma and MIR339, MIR129-2, and MIR124-2 for squamous cell carcinoma. +epigenetics 36598670 hsa-mir-339 Carcinoma, Non-Small-Cell Lung A high level of methylation of the MIR137 and MIR1258 genes was shown for adenocarcinoma and MIR339, MIR129-2, and MIR124-2 for squamous cell carcinoma. +epigenetics 36598670 hsa-mir-137 Carcinoma, Non-Small-Cell Lung A high level of methylation of the MIR137 and MIR1258 genes was shown for adenocarcinoma and MIR339, MIR129-2, and MIR124-2 for squamous cell carcinoma. +epigenetics 36598670 hsa-mir-124-2 Carcinoma, Non-Small-Cell Lung A high level of methylation of the MIR137 and MIR1258 genes was shown for adenocarcinoma and MIR339, MIR129-2, and MIR124-2 for squamous cell carcinoma. +epigenetics 36598670 hsa-mir-375 Carcinoma, Non-Small-Cell Lung Significant differences in the level of methylation of MIR124-2 and MIR375 genes were revealed for smoking patients with squamous cell lung cancer. +genetics_knock down_promote 36598315 hsa-mir-568 Carcinoma, Hepatocellular Also, circ_0097009 knockdown blocked tumor growth in vivoCONCLUSION: Together, this study indicated that the oncogenic function of circ_0097009 in HCC, and circ_0097009/miR-568/RNF38 axis was expected to be a novel therapeutic option for HCC patients (Tab. +lncRNA target 36598302 hsa-mir-146a Myocardial Reperfusion Injury METHODS: The expression levels of SOX2-OT and miR-146a-5p in OGD/R-treated H9C2 cells and in myocardial tissues of MIRI rats were measured by qRT-PCR. CONCLUSIONS: Silencing of SOX2-OT relieved the apoptosis, inflammation, and oxidative stress of myocardial cells via up-regulating miR-146a-5p, contributing to the remission of MIRI (Fig. +transcription factor target 36598122 hsa-mir-155 Bone Diseases Thus, Mir155 showed a catabolic effect on osteogenesis and bone mass phenotype via interaction with the S1pr1 gene, suggesting inhibition of Mir155 as a potential strategy for bone regeneration and bone defect healing. +genetics_knock down_suppress 36597907 hsa-mir-181a Ovarian Neoplasms In this study, the CCMV VLP was applied to encapsulate two different formats of anti-miR-181a oligonucleotides: naked RNA and chemically stabilized RNA to knockdown highly regulated miR-181a in ovarian cancer cells. +other 36597862 hsa-mir-335 Osteosarcoma METHODS: In the current work, the expression of circUSP48, miR-335 and SNIP1 in OS cell lines and tissues were evaluated using qRT-PCR. Importantly, circUSP48 promoted OS malignancy by sponging miR-335 to upregulate SNIP1. +other 36597856 hsa-mir-498 Stomach Neoplasms Moreover, hsa_circ_0001944 sponged miR-498 to increase GSPT1 expression, thereby promoted excessive proliferation and maintained the malignant phenotype of GC cells. CONCLUSION: The present study demonstrates the hsa_circ_0001944/miR-498/GSPT1 axis contributes to GC development. +circRNA target 36597773 hsa-mir-370 Acute Kidney Injury Conclusion: Our data demonstrated that circ_0114428 contributed to septic AKI progression by regulating miR3p-mediated TIMP2 expression, which provided a promising target for septic AKI treatment. +other 36597599 hsa-mir-223 Sjogren's Syndrome MiR3p increased while ITPR3 decreased in samples from SS patients and INF-gamma-induced SGECs. +circulation_biomarker_diagnosis_ns 36597468 hsa-mir-143 Diabetes Mellitus, Type 2 CONCLUSION: Higher miRNA-143 and miRNA-145 expression could be a predictive indicator for obese T2DM cases, decreased status of vitamin-D was also significantly associated with impaired fasting blood sugar and HDL level, therefore it is important to evaluate the vitamin-D status among T2DM cases for better clinical outcome during the intervention. +circulation_biomarker_diagnosis_ns 36597468 hsa-mir-145 Diabetes Mellitus, Type 2 CONCLUSION: Higher miRNA-143 and miRNA-145 expression could be a predictive indicator for obese T2DM cases, decreased status of vitamin-D was also significantly associated with impaired fasting blood sugar and HDL level, therefore it is important to evaluate the vitamin-D status among T2DM cases for better clinical outcome during the intervention. +genetics_overexpression_promote 36597176 hsa-mir-34 Hepatitis B, Chronic Overexpression of pHBV(1.3) further confirmed that HBV downregulates miR-34 expression. +genetics_overexpression_suppress 36597175 hsa-mir-138 Carcinoma, Non-Small-Cell Lung Moreover, overexpression of SNIP1 rescues the miR +other 36596777 hsa-mir-29a Leukemia, Promyelocytic, Acute APA exerts this effect by shortening the 3'UTRs of the Col1a1 and Col1a2 mRNAs, thus removing the binding sites of miR-29a-3p, which would otherwise strongly promote the degradation of both transcripts. +genetics_overexpression_suppress 36596504 hsa-mir-137 Spinal Cord Injuries overexpressing BMMSC exosomes may serve as a treatment option for SCI recovery. +circulation_biomarker_diagnosis_ns 36596338 hsa-mir-548n Aortic Aneurysm, Abdominal CONCLUSION: Serum let-7b-5p and miR548n significantly improved the ability to diagnose AAA. +other 36596006 hsa-mir-149 Ischemic Stroke The results indicated that there were no significant associations between miR-146a C>G (rs2910164), miR-196a2 T>C (rs11614913) and IS risk in the overall analyses, but miR-149 T>C (rs2292832) and miR-499 A>G (rs3746444) increased IS risk under the allelic model, homozygote model and recessive model. +other 36596006 hsa-mir-196a-2 Ischemic Stroke The results indicated that there were no significant associations between miR-146a C>G (rs2910164), miR-196a2 T>C (rs11614913) and IS risk in the overall analyses, but miR-149 T>C (rs2292832) and miR-499 A>G (rs3746444) increased IS risk under the allelic model, homozygote model and recessive model. +other 36596006 hsa-mir-499 Ischemic Stroke The results indicated that there were no significant associations between miR-146a C>G (rs2910164), miR-196a2 T>C (rs11614913) and IS risk in the overall analyses, but miR-149 T>C (rs2292832) and miR-499 A>G (rs3746444) increased IS risk under the allelic model, homozygote model and recessive model. +other 36596006 hsa-mir-146a Ischemic Stroke The results indicated that there were no significant associations between miR-146a C>G (rs2910164), miR-196a2 T>C (rs11614913) and IS risk in the overall analyses, but miR-149 T>C (rs2292832) and miR-499 A>G (rs3746444) increased IS risk under the allelic model, homozygote model and recessive model. +target gene 36595346 hsa-mir-455 Pancreatic Neoplasms IL-6 Accelerates the Proliferation and Metastasis of Pancreatic Cancer Cells via the miR-455-5p/IGF-1R Axis. +exosome 36595161 hsa-mir-138 Alzheimer Disease In the present study, both in vitro and vivo experiments were employed, and we found Catalpol (Ca), the main extract of Rehmannia, could mitigate AD progression both in vitro and in vivo by promoting miR5p level in neural stem cell secreted exosomes. +circulation_biomarker_diagnosis_ns 36594832 hsa-mir-21 Stroke The increase in miR-21a-5p secretion may have biomarker potential, as high blood levels of miR5p in stroke patients were associated with significant disability at hospital discharge. +lncRNA target 36594718 hsa-mir-139 Carcinoma, Hepatocellular CONCLUSION: Matrine inhibited HCC cell malignancy through the circ_0013290/miR +circulation_biomarker_prognosis_down 36594100 hsa-mir-1275 Breast Neoplasms We found that miR-1275 was significantly downregulated in plasma from patients resistant to chemotherapy and in chemoresistant BC cell lines, while patients with low levels of miR-1275 showed poor overall survival. +genetics_overexpression_promote 36594050 hsa-mir-15a Carcinoma, Hepatocellular Moreover, miR-15a-5p overexpression reversed the hsa_circ_0006988-mediated SOR-R and enhanced IGF1 levels in HCC cells. +other 36593966 hsa-mir-217 Periodontitis, Diabetic Finally, antagomiR-217, a miRNA antagonism, was delivered into the periodontium to treat LIP-induced diabetic periodontitis. +genetics_overexpression_promote 36593867 hsa-mir-1258 Carcinoma, Non-Small-Cell Lung miR-1258 overexpression weakened the effect of circ_0000520 overexpression on NSCLC cells. +other 36593510 hsa-mir-146a Asthma RESULTS: The results showed that the expression of miR-16, miR146-a and IL-4 levels in patients with asthma after receiving probiotic supplementation was significantly reduced and miR-133b expression was increased. +other 36593510 hsa-mir-133b Asthma RESULTS: The results showed that the expression of miR-16, miR146-a and IL-4 levels in patients with asthma after receiving probiotic supplementation was significantly reduced and miR-133b expression was increased. +other 36593510 hsa-mir-16 Asthma RESULTS: The results showed that the expression of miR-16, miR146-a and IL-4 levels in patients with asthma after receiving probiotic supplementation was significantly reduced and miR-133b expression was increased. +other 36593385 hsa-mir-31 Uterine Cervical Neoplasms LncRNA HOTAIR enhances RCC2 to accelerate cervical cancer progression by sponging miR-331-3p. +transcription factor target 36593242 hsa-mir-149 Colorectal Neoplasms In conclusion, our findings not only highlight the significance of DDX17 in the aggressive development and prognosis of CRC patients, but also reveal a novel mechanism underlying DDX17-mediated CRC cell metastasis and EMT progression through manipulation of the miR +genetics_GWAS 36593103 hsa-mir-223 Carcinoma, Hepatocellular RESULTS: Genetic deletion of miR-223 markedly exacerbated tumourigenesis in inflammation-associated HCC. +lncRNA target 36592647 hsa-mir-582 Inflammation 5p attenuated the production of pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 through suppressing the degradation of the NF-kappaB inhibitor alpha, followed by the nuclear translocation of NF-kappaB. +lncRNA target 36592647 hsa-mir-582 Immune System Diseases Therefore, exogenously applied miR5p can attenuate the NF-kappaB signaling pathway via targeting Skp1; this provides a prospective therapeutic strategy for treating inflammatory and immune diseases. +circRNA target 36592530 hsa-mir-125b psoriasis 1 Herein our findings showed increased expression of circVAPA and Sirt6 and decreased level of miR-125b-5p in psoriatic lesional tissues and M5-stimulated keratinocytes. CircVAPA participate in the progression of psoriasis through miR-125b-5p/sirt6 axis by regulating proliferation and inflammation of keratinocytes, highlighting a potential therapeutic target for psoriasis. +genetics_GWAS 36591938 hsa-mir-492 Pancreatic Carcinoma In this study, we first found that miR-492 in enhancer loci activated neighboring genes (NR2C1/NDUFA12/TMCC3) and promoted PaCa cell proliferation, migration, and invasion in vitro. +circulation_biomarker_diagnosis_ns 36591868 hsa-mir-10b Breast Neoplasms Furthermore, when PLPNs loaded with a CRISPRi plasmid that targets microRNA-10b (miR-10b) are used in combination with UMMD, it results in the effective repression of miR-10b in breast cancer, simultaneous disturbance of multiple cell migration and invasion-related signaling pathways, and a significant inhibition of lung metastasis. +other 36591806 hsa-mir-126 Prostatic Neoplasms A high degree of MCs infiltration of the PCa tissue was associated with 1.2 times (p=0.0347) higher level of OPN expression and 1.7 (p=0.0051) and 1.65 (p=0.0087) times lower levels of miR-126 and miR-181a expression, respectively. +other 36591804 hsa-mir-3163 Uterine Cervical Neoplasms Taken together, high expression of lncRNA CBR3-AS1 predicts poor prognosis in cervical cancer, and the lncRNA CBR3-AS1/miR-3163/LASP1 pathway plays a vital function in the modulation of cervical cancer cell proliferation and cancer stem cell-like properties. +lncRNA target 36591727 hsa-mir-495 Carcinoma, Non-Small-Cell Lung 3p/CCND1 axis, highlighting a promising target for NSCLC patients. +other 36591654 hsa-mir-662 Breast Neoplasms A total of 844 DElncRNAs, 206 DEmiRNAs and 3295 DEmRNAs were extracted in BC, and 12 RNAs (HOTAIR, AC055854.1, ST8SIA6-AS1, AC105999.2, hsa-miR-1258, hsa-miR-7705, hsa-miR-3662, hsa-miR-4501, CCNB1, UHRF1, SPC24 and SHCBP1) among them were recognized for the construction of a prognostic risk model. +other 36591654 hsa-mir-4501 Breast Neoplasms A total of 844 DElncRNAs, 206 DEmiRNAs and 3295 DEmRNAs were extracted in BC, and 12 RNAs (HOTAIR, AC055854.1, ST8SIA6-AS1, AC105999.2, hsa-miR-1258, hsa-miR-7705, hsa-miR-3662, hsa-miR-4501, CCNB1, UHRF1, SPC24 and SHCBP1) among them were recognized for the construction of a prognostic risk model. +other 36591654 hsa-mir-1258 Breast Neoplasms A total of 844 DElncRNAs, 206 DEmiRNAs and 3295 DEmRNAs were extracted in BC, and 12 RNAs (HOTAIR, AC055854.1, ST8SIA6-AS1, AC105999.2, hsa-miR-1258, hsa-miR-7705, hsa-miR-3662, hsa-miR-4501, CCNB1, UHRF1, SPC24 and SHCBP1) among them were recognized for the construction of a prognostic risk model. +other 36591654 hsa-mir-7705 Breast Neoplasms A total of 844 DElncRNAs, 206 DEmiRNAs and 3295 DEmRNAs were extracted in BC, and 12 RNAs (HOTAIR, AC055854.1, ST8SIA6-AS1, AC105999.2, hsa-miR-1258, hsa-miR-7705, hsa-miR-3662, hsa-miR-4501, CCNB1, UHRF1, SPC24 and SHCBP1) among them were recognized for the construction of a prognostic risk model. +exosome 36591520 hsa-mir-320d Carcinoma, Ovarian Epithelial Subsequently, exosomal miR-320d, miR-4479, and miR +exosome 36591520 hsa-mir-4479 Carcinoma, Ovarian Epithelial Subsequently, exosomal miR-320d, miR-4479, and miR +exosome 36591520 hsa-mir-6763 Carcinoma, Ovarian Epithelial Subsequently, exosomal miR-320d, miR-4479, and miR +other 36591476 hsa-mir-221 Uterine Cervical Neoplasms 3p), and seven mRNA (FGFR1, PRLR, CXCL2, ISG20, ISG15, SDC1, and NR2F2). +other 36591476 hsa-mir-205 Uterine Cervical Neoplasms 3p), and seven mRNA (FGFR1, PRLR, CXCL2, ISG20, ISG15, SDC1, and NR2F2). +virus_miRNA 36591247 hcmv-mir-US33 Fever hcmv-miR-US4-3p, hcmv-miR-US29-3p, hcmv-miR-US5-2-3p, hcmv-miR-UL112-3p, and hcmv-miR-US33-3p most significantly elevated in the serum of fever patients +virus_miRNA 36591247 hcmv-mir-UL112 Fever hcmv-miR-US4-3p, hcmv-miR-US29-3p, hcmv-miR-US5-2-3p, hcmv-miR-UL112-3p, and hcmv-miR-US33-3p most significantly elevated in the serum of fever patients +virus_miRNA 36591247 hcmv-mir-US5 Fever hcmv-miR-US4-3p, hcmv-miR-US29-3p, hcmv-miR-US5-2-3p, hcmv-miR-UL112-3p, and hcmv-miR-US33-3p most significantly elevated in the serum of fever patients +virus_miRNA 36591247 hcmv-mir-US29 Fever hcmv-miR-US4-3p, hcmv-miR-US29-3p, hcmv-miR-US5-2-3p, hcmv-miR-UL112-3p, and hcmv-miR-US33-3p most significantly elevated in the serum of fever patients +virus_miRNA 36591247 hcmv-mir-US4 Fever hcmv-miR-US4-3p, hcmv-miR-US29-3p, hcmv-miR-US5-2-3p, hcmv-miR-UL112-3p, and hcmv-miR-US33-3p most significantly elevated in the serum of fever patients +other 36590967 hsa-mir-338 Pulmonary Disease, Chronic Obstructive "3p correlated with airway eosinophilia and were able to distinguish ""pure eosinophilic"" COPD from other airway inflammatory subtypes (AUC 0.94 and 0.85, respectively)." +lncRNA target 36590397 hsa-mir-1 Colitis Further analysis reveals that the number of proliferative epithelial cells, which characterizes the inflammatory process and the recovery of epithelia in colitis, is mainly determined by the inhibition of MIR31 on IL17RA. +lncRNA target 36590309 hsa-mir-361 Esophageal Neoplasms Silencing the target genes of miR +target gene 36589606 hsa-mir-20a Arthritis, Rheumatoid LncRNA cardiac autophagy inhibitory factor is downregulated in rheumatoid arthritis and suppresses the apoptosis of fibroblast-like synoviocytes by promoting the maturation of miRNA-20a. +circulation_biomarker_diagnosis_up 36588450 hsa-mir-16 Arthritis, Rheumatoid We aimed to evaluate miR-223 and miR-16 roles in monitoring RA activity and to investigate if there is a link between their plasma levels and US7 score. +other 36588450 hsa-mir-223 Arthritis, Rheumatoid miR-16 and miR-223 levels were correlated with synovitis PDUS7 (r = 0.34, p < 0.01 and r= 0.25, P = 0.03, respectively). The miR-16 level was linked to synovitis GSUS7 and synovitis PDUS7 changes but miR-223 only linked to synovitis PDUS. +genetics_knock down_promote 36588357 hsa-mir-142 Liver Neoplasms Injection with sh-CRNDE virus reduced in vivo tumor growth of liver cancer through up-regulation of miR-142 and down-regulation of EZH2 and HIF-1alpha. In conclusion, knockdown of CRNDE suppressed cell proliferation, glycolysis, and tumor growth of liver cancer through EZH2/miR-142/HIF-1alpha. +lncRNA target 36587882 hsa-mir-15 Inflammation CONCLUSION: Collectively, our study revealed the previously undefined mechanistic role of Kabasura Kudineer (KK) that alleviates the LPS-induced oxidative damage associated with inflammation by inhibiting the miRNA5p/IL-10Ralpha axis. +other 36587497 hsa-mir-451a Placenta Diseases Maternal expression of miR-let-7d-3p and miR-451a during gestation influences the INTRODUCTION: Studies on maternal microRNA expression have emerged to better understand regulatory mechanisms during the gestational period, since microRNA expression has been associated with pregnancy disorders. +other 36587497 hsa-let-7d Placenta Diseases Maternal expression of miR-let-7d-3p and miR-451a during gestation influences the INTRODUCTION: Studies on maternal microRNA expression have emerged to better understand regulatory mechanisms during the gestational period, since microRNA expression has been associated with pregnancy disorders. +other 36587063 hsa-mir-28 Dermatitis, Atopic 5p, miR-378a-3p and miR-203a were validated as upregulated in the skin of AD and PV patients. +other 36587063 hsa-mir-203a psoriasis 1 5p, miR-378a-3p and miR-203a were validated as upregulated in the skin of AD and PV patients. +other 36587063 hsa-mir-1 Dermatitis, Atopic 5p, miR-378a-3p and miR-203a were validated as upregulated in the skin of AD and PV patients. +other 36587063 hsa-mir-378a psoriasis 1 5p, miR-378a-3p and miR-203a were validated as upregulated in the skin of AD and PV patients. +other 36587063 hsa-mir-203a Dermatitis, Atopic 5p, miR-378a-3p and miR-203a were validated as upregulated in the skin of AD and PV patients. +other 36587063 hsa-mir-378a Dermatitis, Atopic 5p, miR-378a-3p and miR-203a were validated as upregulated in the skin of AD and PV patients. +other 36587063 hsa-mir-1 psoriasis 1 5p, miR-378a-3p and miR-203a were validated as upregulated in the skin of AD and PV patients. +other 36587063 hsa-mir-28 psoriasis 1 5p, miR-378a-3p and miR-203a were validated as upregulated in the skin of AD and PV patients. +genetics_overexpression_promote 36587050 hsa-mir-125a ankylosing spondylitis 1 Accordingly, poorly expressed MEG3 and TNF alpha induced protein 3 (TNFAIP3) as well as overexpressed microRNA-125a-5p (miR-125a-5p) were noted in the serum of AS patients and in ASMSCs during the osteogenic induction process. +circulation_biomarker_diagnosis_ns 36586536 hsa-mir-96 Polycystic Ovary Syndrome Furthermore, we demonstrated that the elevated circulating miR +genetics_knock down_promote 36586093 hsa-mir-1299 Carcinoma, Non-Small-Cell Lung MiR-1299 inhibitor reversed circ_0020123 knockdown-mediated influence on malignant behaviors of NSCLC cells under TSIIA treatment. +lncRNA target 36586008 hsa-mir-361 Esophageal Neoplasms 3p or COL5A1 axis, indicating that BBOX1-AS1 might be a potential therapeutic target for EC therapy. +circulation_biomarker_diagnosis_ns 36585554 hsa-mir-188 Vascular Diseases 3p), and toll-like receptor 4 (TLR4) expression was determined via real-time quantitative polymerase chain reaction (RT-qPCR) in serum samples from AS patients and healthy volunteers. +other 36585230 hsa-mir-181c Lung Neoplasms Results UALCAN analysis displayed that the expression of miR-181c was significantly higher and RECK expression was significantly lower in lung cancer tissues compared to that in normal tissues. +other 36585203 hsa-mir-1 Glioblastoma CONCLUSION: Our results demonstrated that NIPP is able to efficiently attenuate growth of GBM cells and suggest AKT1, ERK1/2 and miR-1 to be pivotal factors of NIPP-modulated cellular signalling. +transcription factor target 36585184 hsa-mir-877 Esophageal Squamous Cell Carcinoma 3p acts as a tumour suppressor gene in ESCC cells, and its down-regulation in ESCC tissues is associated with a poor prognosis. +circulation_biomarker_diagnosis_ns 36584787 hsa-mir-4500 Urticaria 3p) increased at least 3-fold in the serum of individuals with Blastocystis-positive compared to Blastocystis-negative subjects. +other 36584787 hsa-mir-5191 Urticaria RESULTS: Compared to Blastocystis-negative (BN)-CSU patients, expression of 3 miRNAs (hsa-miR-3183, hsa-miR-4469, hsa-miR-5191) were found to be downregulated by at least two-fold (p < 0.05) in Blastocystis-positive (BP)-CSU patients. +circulation_biomarker_diagnosis_ns 36584787 hsa-mir-5587 Urticaria 3p) increased at least 3-fold in the serum of individuals with Blastocystis-positive compared to Blastocystis-negative subjects. +other 36584787 hsa-mir-4469 Urticaria RESULTS: Compared to Blastocystis-negative (BN)-CSU patients, expression of 3 miRNAs (hsa-miR-3183, hsa-miR-4469, hsa-miR-5191) were found to be downregulated by at least two-fold (p < 0.05) in Blastocystis-positive (BP)-CSU patients. +circulation_biomarker_diagnosis_ns 36584787 hsa-mir-4803 Urticaria 3p) increased at least 3-fold in the serum of individuals with Blastocystis-positive compared to Blastocystis-negative subjects. +circulation_biomarker_diagnosis_ns 36584787 hsa-mir-5680 Urticaria 3p) increased at least 3-fold in the serum of individuals with Blastocystis-positive compared to Blastocystis-negative subjects. +circulation_biomarker_diagnosis_ns 36584787 hsa-mir-4666a Urticaria 3p) increased at least 3-fold in the serum of individuals with Blastocystis-positive compared to Blastocystis-negative subjects. +circulation_biomarker_diagnosis_ns 36584787 hsa-mir-4661 Urticaria 3p) increased at least 3-fold in the serum of individuals with Blastocystis-positive compared to Blastocystis-negative subjects. +other 36584787 hsa-mir-183 Urticaria RESULTS: Compared to Blastocystis-negative (BN)-CSU patients, expression of 3 miRNAs (hsa-miR-3183, hsa-miR-4469, hsa-miR-5191) were found to be downregulated by at least two-fold (p < 0.05) in Blastocystis-positive (BP)-CSU patients. +circulation_biomarker_diagnosis_ns 36584787 hsa-mir-382 Urticaria 3p) increased at least 3-fold in the serum of individuals with Blastocystis-positive compared to Blastocystis-negative subjects. +lncRNA target 36584452 hsa-mir-16 Inflammation CONCLUSION: EGCG may effectively lower the levels of sepsis-induced inflammatory cytokines by targeting the PVT1/miR5p/TLR4 axis. +lncRNA target 36584452 hsa-mir-16 Sepsis CONCLUSION: EGCG may effectively lower the levels of sepsis-induced inflammatory cytokines by targeting the PVT1/miR5p/TLR4 axis. +genetics_knock down_suppress 36583803 hsa-mir-29c Carcinoma, Hepatocellular CONCLUSION: miR-29c, a key gene regulating HCC, is lowly expressed in HCC, its overexpression can remarkably inhibit the biological function of tumor cells. +genetics_overexpression_suppress 36583788 hsa-mir-758 Uterine Cervical Neoplasms 3p overexpression on CC cell progression. +lncRNA target 36583714 hsa-mir-34a Liver Cirrhosis The miR-34a-mediated ductular reactions may be functioning through Sirt +lncRNA target 36583660 hsa-mir-27a Thyroid Cancer, Papillary Our study highlights that DNAJC3-AS1 inhibits miR-27a-3p to promote CCBE1 expression, thereby facilitating PTC development. +genetics_overexpression_promote 36583484 hsa-mir-101 Carcinoma, Non-Small-Cell Lung 3p weakened the promoting effect of overexpressed KPNA2 on LUSC malignant progression. +other 36583233 hsa-mir-15b Coronary Artery Disease RESULTS: The pairwise comparison revealed that 12 miRNAs were significantly downregulated in HF-CAD patients compared to controls, whereas 4 miRNAs were considerably deregulated in HF-nonCAD patients, with miRNA-15b-5p being downregulated in both groups. +other 36583233 hsa-mir-15b Heart Failure RESULTS: The pairwise comparison revealed that 12 miRNAs were significantly downregulated in HF-CAD patients compared to controls, whereas 4 miRNAs were considerably deregulated in HF-nonCAD patients, with miRNA-15b-5p being downregulated in both groups. +other 36583003 hsa-mir-4732 Bulbospinal neuronopathy, X-linked recessive 5p, and hsa-let-7b-5p were differentially expressed between PBMAH and adenoma (P = 0.019, 0.006, and 0.003, respectively). +other 36583003 hsa-mir-4732 Adenoma 5p, and hsa-let-7b-5p were differentially expressed between PBMAH and adenoma (P = 0.019, 0.006, and 0.003, respectively). +other 36583003 hsa-mir-631 Bulbospinal neuronopathy, X-linked recessive Hsa-miR-631, hsa-miR-513b-5p, hsa-miR5p, and hsa-miR-548av-5p/548k were differentially expressed between PBMAH subtype 2 and adenoma (P = 0.027, 0.027, 0.027, and 1.53E-04, respectively), but not between PBMAH, as a whole, and adenoma. +other 36583003 hsa-mir-513b Bulbospinal neuronopathy, X-linked recessive Hsa-miR-631, hsa-miR-513b-5p, hsa-miR5p, and hsa-miR-548av-5p/548k were differentially expressed between PBMAH subtype 2 and adenoma (P = 0.027, 0.027, 0.027, and 1.53E-04, respectively), but not between PBMAH, as a whole, and adenoma. +other 36583003 hsa-mir-513b Adenoma Hsa-miR-631, hsa-miR-513b-5p, hsa-miR5p, and hsa-miR-548av-5p/548k were differentially expressed between PBMAH subtype 2 and adenoma (P = 0.027, 0.027, 0.027, and 1.53E-04, respectively), but not between PBMAH, as a whole, and adenoma. +other 36583003 hsa-mir-631 Adenoma Hsa-miR-631, hsa-miR-513b-5p, hsa-miR5p, and hsa-miR-548av-5p/548k were differentially expressed between PBMAH subtype 2 and adenoma (P = 0.027, 0.027, 0.027, and 1.53E-04, respectively), but not between PBMAH, as a whole, and adenoma. +other 36583003 hsa-mir-1180 Adenoma 5p, and hsa-let-7b-5p were differentially expressed between PBMAH and adenoma (P = 0.019, 0.006, and 0.003, respectively). +other 36583003 hsa-let-7b Adenoma 5p, and hsa-let-7b-5p were differentially expressed between PBMAH and adenoma (P = 0.019, 0.006, and 0.003, respectively). +other 36583003 hsa-let-7b Bulbospinal neuronopathy, X-linked recessive 5p, and hsa-let-7b-5p were differentially expressed between PBMAH and adenoma (P = 0.019, 0.006, and 0.003, respectively). +other 36583003 hsa-mir-1180 Bulbospinal neuronopathy, X-linked recessive 5p, and hsa-let-7b-5p were differentially expressed between PBMAH and adenoma (P = 0.019, 0.006, and 0.003, respectively). +other 36583003 hsa-mir-6805 Adenoma Hsa-miR-631, hsa-miR-513b-5p, hsa-miR5p, and hsa-miR-548av-5p/548k were differentially expressed between PBMAH subtype 2 and adenoma (P = 0.027, 0.027, 0.027, and 1.53E-04, respectively), but not between PBMAH, as a whole, and adenoma. +other 36583003 hsa-mir-548av Bulbospinal neuronopathy, X-linked recessive Hsa-miR-631, hsa-miR-513b-5p, hsa-miR5p, and hsa-miR-548av-5p/548k were differentially expressed between PBMAH subtype 2 and adenoma (P = 0.027, 0.027, 0.027, and 1.53E-04, respectively), but not between PBMAH, as a whole, and adenoma. +other 36583003 hsa-mir-548av Adenoma Hsa-miR-631, hsa-miR-513b-5p, hsa-miR5p, and hsa-miR-548av-5p/548k were differentially expressed between PBMAH subtype 2 and adenoma (P = 0.027, 0.027, 0.027, and 1.53E-04, respectively), but not between PBMAH, as a whole, and adenoma. +other 36583003 hsa-mir-6805 Bulbospinal neuronopathy, X-linked recessive Hsa-miR-631, hsa-miR-513b-5p, hsa-miR5p, and hsa-miR-548av-5p/548k were differentially expressed between PBMAH subtype 2 and adenoma (P = 0.027, 0.027, 0.027, and 1.53E-04, respectively), but not between PBMAH, as a whole, and adenoma. +genetics_GWAS 36582685 hsa-mir-216a Colonic Neoplasms In conclusions, lnc-LAMC2-1:1 SNP rs2147578 was involved in promoting COAD progression by targeting miR-216a-3p/HMGB3, and this study will provide a novel molecular target for COAD. +exosome 36582605 hsa-mir-122 Thyroid Neoplasms Cancer stem cell-like cells-derived exosomal lncRNA CDKN2B-AS1 promotes biological characteristics in thyroid cancer via miR-122-5p/P4HA1 axis. +other 36582505 hsa-mir-122 Chilblain lupus METHODS: The expression of adenosine deaminase acting on RNA-1 (ADAR1) and miR-122 was evaluated in liver tissues from patients with CHB concurrent NAFLD. +genetics_overexpression_suppress 36582030 hsa-mir-700 Skin Diseases MiR5p overexpression or GPX4 downregulation inhibited the circ-Ash1l protective effects of UV-induced endothelial progenitor cell (EPC) damage. +genetics_overexpression_promote 36581129 hsa-mir-663b Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: Our study illustrated that circ_0049396 overexpression inhibited the malignant behavior of OSCC cells by regulating the miR-663b/ENDOU axis. +lncRNA target 36581048 hsa-mir-124 Liver Injury Collectively, our findings suggest that miR-124 can potentially serve as a predictive biomarker for HBV-ACLF prognosis and may represent a promising therapeutic target for relieving severe liver injury resulting from cytokine storms. +lncRNA target 36580691 hsa-mir-181b Depressive Disorder, Major 3p, miR-181b-3p and miR-3690 - may be biomarkers with targets that are implicated in the pathophysiology of depression. +lncRNA target 36580691 hsa-mir-542 Depressive Disorder, Major 3p, miR-181b-3p and miR-3690 - may be biomarkers with targets that are implicated in the pathophysiology of depression. +lncRNA target 36580691 hsa-mir-3690 Depressive Disorder, Major 3p, miR-181b-3p and miR-3690 - may be biomarkers with targets that are implicated in the pathophysiology of depression. +circRNA target 36580535 hsa-mir-203a Osteosarcoma Using bioinformatics analysis, we built three circRNA-miRNA-mRNA regulatory modules (circ_0001060-miR-203a-5p-TRIM21, circ_0001060-miR-208b-5p-MAP3K5, and circ_0001060-miR-203a-5p-PRKX), suggesting that these signaling axes may be involved in the inhibitory effect of circ_0001060 on OS. +circRNA target 36580535 hsa-mir-208b Osteosarcoma Using bioinformatics analysis, we built three circRNA-miRNA-mRNA regulatory modules (circ_0001060-miR-203a-5p-TRIM21, circ_0001060-miR-208b-5p-MAP3K5, and circ_0001060-miR-203a-5p-PRKX), suggesting that these signaling axes may be involved in the inhibitory effect of circ_0001060 on OS. +other 36580437 hsa-mir-515 Pre-Eclampsia This study tried to elicit the functional mechanism of miR5p in trophoblast cell behaviors in PE. +transcription factor target 36579994 hsa-mir-233 Carcinoma, Hepatocellular CONCLUSIONS: Our data suggest a potential role for miR3p as a prognostic as well as a therapeutic target for HCC. +lncRNA target 36579395 hsa-mir-141 Triple Negative Breast Neoplasms 3p could suppress autophagy and inhibit proliferation, migration, and invasion by targeting Malat1 in TNBC cells under hypoxia. +other 36579331 hsa-mir-296 Sepsis Conclusion: This study demonstrated the roles of miR-650 and miR3p genes in SA-AKI. +other 36579331 hsa-mir-650 Acute Kidney Injury Conclusion: This study demonstrated the roles of miR-650 and miR3p genes in SA-AKI. +other 36579331 hsa-mir-296 Acute Kidney Injury Conclusion: This study demonstrated the roles of miR-650 and miR3p genes in SA-AKI. +other 36579331 hsa-mir-650 Sepsis Conclusion: This study demonstrated the roles of miR-650 and miR3p genes in SA-AKI. +genetics_overexpression_suppress 36578555 hsa-mir-122 Carcinoma, Renal Cell Overexpression of circ_DENND1B regulated TIMP2 level by inhibiting miR +lncRNA target 36578092 hsa-mir-130a Breast Neoplasms CONCLUSION: This study presents a mechanism involving the DSCAM-AS1/miR-130a/ESR1 genomic axis through which progesterone impedes breast cancer cell invasion and migration. +transcription factor target 36578050 hsa-mir-4443 Esophageal Squamous Cell Carcinoma CONCLUSION: In this study, miR-4443 is found to promote radiotherapy resistance in ESCC cells by regulating PTPRJ expression, which provides a new perspective and clue to alleviate radioresistance. +circulation_biomarker_diagnosis_ns 36577694 hsa-mir-206 Depression OBJECTIVES: Our study aimed to detect the expression of miRNA-206 in the blood and clarify the relationship among miRNA-206, pain, anxiety and depression of BMS patients. miRNA-206 expression in the peripheral blood of patients with BMS is positively correlated with pain and depression, which may be involved in the pathogenesis of BMS. +circulation_biomarker_diagnosis_ns 36577694 hsa-mir-206 Anxiety Disorders OBJECTIVES: Our study aimed to detect the expression of miRNA-206 in the blood and clarify the relationship among miRNA-206, pain, anxiety and depression of BMS patients. +circulation_biomarker_diagnosis_up 36577155 hsa-mir-21b Graft vs Host Disease Th1, Th17 and Treg cells were respectively isolated from peripheral blood CD4 T cells of allo-HSCT patients, and we found that proportions of Th1 and Th17 were markedly increased, while Treg proportion was significantly decreased in aGVHD patients post transplantation compared with non-aGVHD patients, accompanied by decreased ADAR1 and increased miR-21b levels. Collectively, ADAR1 suppresses miR-21b production and improves Foxp3-mediated Treg cell function to inhibit the progression of aGVHD after allo-HSCT. +lncRNA target 36577153 hsa-mir-34a Neuralgia CONCLUSION: TMPZ and AGS-IV ameliorate SCI-elicited NP via the OIP5-AS1/miR-34a/Sirt1/NF-kappaB pathway. +lncRNA target 36577153 hsa-mir-34a Spinal Cord Injuries CONCLUSION: TMPZ and AGS-IV ameliorate SCI-elicited NP via the OIP5-AS1/miR-34a/Sirt1/NF-kappaB pathway. +circulation_biomarker_diagnosis_ns 36577123 hsa-mir-375 Liver Neoplasms Conclusions: According to our meta-analysis, measuring serum miR-375 has high sensitivity and specificity, which will facilitate its clinical application in liver cancer monitoring. +other 36577032 hsa-mir-503 Diabetes Mellitus, Type 1 5p were significantly upregulated, while miR-10a-5p was downregulated in patients with CCP compared with CFP (all fold change >+/-1.5; P < 0.05). +other 36577032 hsa-mir-10a Diabetes Mellitus, Type 1 5p were significantly upregulated, while miR-10a-5p was downregulated in patients with CCP compared with CFP (all fold change >+/-1.5; P < 0.05). +other 36577032 hsa-let-7d Diabetes Mellitus, Type 1 5p were significantly upregulated, while miR-10a-5p was downregulated in patients with CCP compared with CFP (all fold change >+/-1.5; P < 0.05). +other 36577032 hsa-mir-106b Diabetes Mellitus, Type 1 5p were significantly upregulated, while miR-10a-5p was downregulated in patients with CCP compared with CFP (all fold change >+/-1.5; P < 0.05). +other 36577032 hsa-mir-93 Diabetes Mellitus, Type 1 5p were significantly upregulated, while miR-10a-5p was downregulated in patients with CCP compared with CFP (all fold change >+/-1.5; P < 0.05). +target gene 36576783 hsa-mir-326 Carcinoma, Non-Small-Cell Lung Circ-PGAM1 Enhances Matrine Resistance of Non-Small Cell Lung Cancer via the miR-326/CXCR5 Axis. +target gene 36576714 hsa-mir-378a Hepatoblastoma LINC01023 Promotes the Hepatoblastoma Tumorigenesis via miR-378a-5p/WNT3 Axis. +genetics_knock down_promote 36575638 hsa-mir-92a Coronary Artery Disease Loss of LPP3 in CAD is associated with an increase in the LPP3 inhibitor, miR-92a. +lncRNA target 36575638 hsa-mir-92a Fibromuscular Dysplasia miR-92a is elevated in CAD arterioles (fold change: 1.9 0.01 P = 0.04), while inhibition of miR-92a restored NO-mediated FMD (CAD), and enhancing miR-92a expression (non-CAD) elicited H(2) O(2) -mediated dilatation (P < 0.0001). Inhibition of miR-92a restores nitric oxide-mediated FMD in the microvasculature of CAD patients. +other 36575638 hsa-mir-92a Vascular Diseases We investigated the role of LPP3 and miR-92a as a mechanism for microvascular dysfunction in CAD. +other 36575500 hsa-mir-122 Muscular Dystrophy, Facioscapulohumeral 3p were differentially expressed compared to matched-controls in all groups but apparently, each type of muscular dystrophy showed a specific pattern of miR expression. +circulation_biomarker_prognosis_ns 36575500 hsa-mir-23 Muscular Dystrophy, Facioscapulohumeral CONCLUSIONS: Although limited by the small number of patients included in this study, we propose here a specific combination of circulating miR +circulation_biomarker_diagnosis_ns 36575500 hsa-mir-23b Muscular Dystrophy, Facioscapulohumeral Four of these circulating miRs (miR +other 36575500 hsa-mir-192 Muscular Dystrophy, Facioscapulohumeral 3p were differentially expressed compared to matched-controls in all groups but apparently, each type of muscular dystrophy showed a specific pattern of miR expression. +circulation_biomarker_diagnosis_ns 36575500 hsa-mir-19b Muscular Dystrophy, Facioscapulohumeral Four of these circulating miRs (miR +lncRNA target 36575320 hsa-mir-29a lacrimal gland adenoid cystic carcinoma miR-29a-3p can specifically target the 3' UTR of Quaking mRNA and down-regulate Quaking expression, thereby inhibiting the proliferation, migration, and epithelial-mesenchymal transition of LACC cells. +genetics_knock down_promote 36575008 hsa-mir-342 Carcinoma, Non-Small-Cell Lung 3p) sponge, and circ_0006220 knockdown-induced changes on the phenotypes of NSCLC cells were largely overturned by the knockdown of miR +lncRNA target 36574754 hsa-mir-19b Carcinoma, Endometrioid CONCLUSIONS: LINC01857 exacerbated EC cell malignant behaviors via the miR-19b-3p/ELAVL1/MYCN axis. +circRNA target 36574090 hsa-mir-142 Lung Neoplasms Taken together, circTAB2 serves as an inhibitory role in lung cancer through a novel circTAB2 /miR-3142 /GLIS2 /AKT pathway and could be exploited a novel marker in lung cancer. +circulation_biomarker_diagnosis_up 36573890 hsa-mir-124 Inflammatory Bowel Diseases Consistently, miR-124 expression was upregulated in the rectal biopsies and blood samples of UC patients and a parallel reduction in Th17 cells and IL17a levels was observed in serum samples. +genetics_knock down_promote 36573325 hsa-mir-548i Carcinoma, Non-Small-Cell Lung Moreover, miR-548I was targeted by circ_0008003, and miR-548I knockdown reversed the influence of circ_0008003 silence on NSCLC progression. CONCLUSION: Circular RNA hsa_circ_0008003 promoted progression in NSCLC by sponging miR-548I and regulating KPNA4 expression, hinting that circ_0008003 participates in NSCLC pathogenesis. +other 36573168 hsa-mir-146a psoriasis 1 Moreover, expression levels of miR-146a-3p were higher in psoriatic HDMECs than in normal controls. +other 36573051 hsa-mir-21 Rectal Neoplasms 5p were both found to have a significant correlation with poor prognosis and higher expression in rectal adenocarcinoma. +other 36573051 hsa-mir-455 Rectal Neoplasms 5p were both found to have a significant correlation with poor prognosis and higher expression in rectal adenocarcinoma. +genetics_overexpression_suppress 36572886 hsa-mir-338 Osteoarthritis 3p silencing/overexpression) were incubated with IL-1beta-induced ATDC5 cells, followed by evaluation of the chondrocyte proliferation, degradation, and inflammation injury. +transcription factor target 36572643 hsa-mir-297 Endometriosis METHODS: ESCs were isolated from infertile endometriosis and normal patients and were transfected with miR-297 mimic or miR-297 inhibitor or respective control. +circRNA target 36572073 hsa-mir-556 Osteosarcoma 5p inhibitor. +other 36571367 hsa-mir-138 Diabetic Neuropathies These findings suggest that the circ_0002538/miR5p/PLLP axis can promote the migration of Schwann cells in diabetic peripheral neuropathy patients, improving myelin sheath structure and nerve function. +transcription factor target 36571232 hsa-mir-132 Colonic Neoplasms 3p regulates colon cancer cell sensitivity to antibody-mediated CDC by directly targeting CD55. +exosome 36570020 hsa-mir-181a Lung Injury CONCLUSION: Consequently, we concluded that ADSC-derived exosomal miR-181a-5p alleviated Klebsiella pneumonia infection-induced lung injury by targeting STAT3 signaling. ADSC-derived exosomal miR-181a-5p may serve as a potential candidate for the treatment of Klebsiella pneumonia infection-induced lung injury. +lncRNA target 36569509 hsa-mir-200a Teratoma CONCLUSION: This novel miRNA panel (miRNA-375, miRNA-200a-3p, miRNA-200a-5p and miRNA-200b-3p) did not distinguish teratoma from nonmalignant necrotic/fibrotic tissues or nonviable tumours in patients with NSGCT undergoing post-chemotherapy consolidation surgery. +lncRNA target 36569509 hsa-mir-375 Teratoma CONCLUSION: This novel miRNA panel (miRNA-375, miRNA-200a-3p, miRNA-200a-5p and miRNA-200b-3p) did not distinguish teratoma from nonmalignant necrotic/fibrotic tissues or nonviable tumours in patients with NSGCT undergoing post-chemotherapy consolidation surgery. +lncRNA target 36569509 hsa-mir-200b Teratoma CONCLUSION: This novel miRNA panel (miRNA-375, miRNA-200a-3p, miRNA-200a-5p and miRNA-200b-3p) did not distinguish teratoma from nonmalignant necrotic/fibrotic tissues or nonviable tumours in patients with NSGCT undergoing post-chemotherapy consolidation surgery. +genetics_knock down_promote 36569483 hsa-mir-215 Pulmonary Fibrosis 5p knockdown on PQ-induced pulmonary fibrosis. +lncRNA target 36569479 hsa-mir-150 Carcinoma, Non-Small-Cell Lung We validate that RSV influences mitophagy and PTX resistance in NSCLC via ZFAS1/miR +transcription factor target 36569394 hsa-mir-211 Dyspepsia Targeting miR-211 or the MAPK pathway may be a potential intervention for FD. +target gene 36569343 hsa-mir-3677 Leukemia, Monocytic, Acute Ginsenoside Rk3 Inhibits the Extramedullary Infiltration of Acute Monocytic Leukemia Cell via miR-3677-5p/CXCL12 Axis. +other 36568518 hsa-mir-30 Stomach Neoplasms DARS-AS1 modulates cell proliferation and migration of gastric cancer cells by regulating miR-330-3p/NAT10 axis. +lncRNA target 36567178 hsa-mir-376b Carcinoma, Hepatocellular Bioinformatics analysis based on Lncbase, miRDB and TargetScan databases showed MK5-AS1 competitively bound to miR-376b-5p that prevented epithelial cell transforming sequence 2 (ECT2) from miRNA-mediated degradation, thus facilitated HCC metastasis. +exosome 36567149 hsa-mir-145 Gynatresia Exosomal miR +exosome 36567149 hsa-mir-145 adhesions of uterus CONCLUSIONS: UCMSC-exos might reverse endometrial stromal cell fibrosis by regulating the miR5p/ZEB2 axis, representing a potential novel strategy to promote endometrial repair. +lncRNA target 36567017 hsa-mir-205 Hashimoto Disease Under stress conditions, such as ultraviolet radiation, we in addition show HITT stability increases as a consequence of MiR-205 downregulation, inhibiting MFN2-mediated fusion and leading to apoptosis. +transcription factor target 36566019 hsa-mir-337 Urinary Bladder Neoplasms 3p may act as a candidate therapeutic target in BC treatments. +other 36566010 hsa-mir-210 Glaucoma 3p level/activity represents a potential new therapeutic strategy for POAG. +genetics_overexpression_promote 36565612 hsa-mir-2114 Ovarian Neoplasms Cx26 overexpression and miR +genetics_overexpression_promote 36565360 hsa-mir-4299 Pancreatic Carcinoma ADAM17 overexpression could reverse miR-4299 effects on PC cell viability, invasion, apoptosis, and immune escape. +circulation_biomarker_diagnosis_ns 36564725 hsa-mir-338 Sepsis RESULTS: The levels of miR3p were significantly lower in serum from patients with sepsis-induced kidney injury compared to the serum from healthy volunteers (P < 0.05). +circulation_biomarker_diagnosis_ns 36564725 hsa-mir-338 Kidney Diseases 3p were significantly lower in serum from patients with sepsis-induced kidney injury compared to the serum from healthy volunteers (P < 0.05). +other 36564279 hsa-mir-548aq Breast Neoplasms 3p, miR-548aq-5p and miR-4710 and the three-miRNA signature as biomarkers for breast cancer with ALNM. +other 36564279 hsa-mir-4710 Breast Neoplasms 3p, miR-548aq-5p and miR-4710 and the three-miRNA signature as biomarkers for breast cancer with ALNM. +other 36564279 hsa-mir-367 Breast Neoplasms 3p, miR-548aq-5p and miR-4710 and the three-miRNA signature as biomarkers for breast cancer with ALNM. +transcription factor target 36564067 hsa-mir-126 Wounds and Injuries 5p may be a molecular target for MI treatment. +lncRNA target 36564067 hsa-mir-126 Myocardial Infarction 5p may be a molecular target for MI treatment. +circRNA target 36563841 hsa-mir-351 Diabetes, Gestational CONCLUSION: Maternal exercise reverses the dysregulated circ_0003226/circ_0015638/miR +circRNA target 36563841 hsa-mir-3102 Diabetes, Gestational CONCLUSION: Maternal exercise reverses the dysregulated circ_0003226/circ_0015638/miR +other 36563751 hsa-mir-143 Glima Brain lower and grade glioma patients who had higher levels of TP53, hsa-miR-25, hsa-miR-34, hsa-miR-222, and hsa-miR-143 had a reduced likelihood of survival. +transcription factor target 36562844 hsa-mir-338 Coronary Disease 3p may be a diagnostic biomarker and therapeutic target for coronary heart disease. +circRNA target 36562476 hsa-mir-761 Triple Negative Breast Neoplasms In-depth mechanism analysis indicated that circDUSP1 acts as an endogenous sponge of miR-761 to reduce its suppression on target gene DACT2 expression in TNBC. +lncRNA target 36561980 hsa-mir-142 Myocardial Reperfusion Injury 3p can negatively regulate dopamine receptor D2 (DRD2), which acted as an anti-inflammatory factor to suppress NF-kappaB-dependent inflammation and prevent MIRI. +other 36561976 hsa-mir-141 Mitochondrial Diseases MicroRNA-141 (miR-141) has been implicated in the mitochondrial dysfunction in cell-based models of oxidant stress. +other 36561887 hsa-mir-200b Nervous System Diseases We investigated the physiological roles of miR-146a and miR-200b that are differentially expressed in neurological disorders such as Alzheimer's disease and schizophrenia, particularly in learning and memory mechanisms. +other 36561887 hsa-mir-200b Schizophrenia We investigated the physiological roles of miR-146a and miR-200b that are differentially expressed in neurological disorders such as Alzheimer's disease and schizophrenia, particularly in learning and memory mechanisms. +other 36561887 hsa-mir-146a Alzheimer Disease We investigated the physiological roles of miR-146a and miR-200b that are differentially expressed in neurological disorders such as Alzheimer's disease and schizophrenia, particularly in learning and memory mechanisms. +other 36561887 hsa-mir-146a Nervous System Diseases We investigated the physiological roles of miR-146a and miR-200b that are differentially expressed in neurological disorders such as Alzheimer's disease and schizophrenia, particularly in learning and memory mechanisms. +other 36561887 hsa-mir-146a Schizophrenia We investigated the physiological roles of miR-146a and miR-200b that are differentially expressed in neurological disorders such as Alzheimer's disease and schizophrenia, particularly in learning and memory mechanisms. +other 36561887 hsa-mir-200b Alzheimer Disease We investigated the physiological roles of miR-146a and miR-200b that are differentially expressed in neurological disorders such as Alzheimer's disease and schizophrenia, particularly in learning and memory mechanisms. +lncRNA target 36561847 hsa-mir-4270 Colonic Neoplasms More importantly, treatment with a miR-4270 inhibitor not only rescued the tumor-suppressing effect of ELFN1-AS1 silencing but also abrogated the tumor suppressor functions of AURKB silencing in CC cells. +lncRNA target 36561842 hsa-mir-4711 Intervertebral Disc Degeneration Overall, silencing ZFAS1 inhibits IDD progression by reducing NP cell apoptosis and ECM degradation through the miR5p/AAK1 axis. +other 36561253 hsa-mir-218 Aortic Aneurysm, Abdominal BACKGROUND: To explore the effects of miRNA5p on inflammation and extracellular matrix proteins of vascular smooth muscle cell line in abdominal aortic aneurysm (AAA). +other 36561136 hsa-mir-186 Alzheimer Disease 5p were determined by COX regression, AD transformation status and aberrant miRNAs. +other 36561136 hsa-mir-425 Alzheimer Disease 5p were determined by COX regression, AD transformation status and aberrant miRNAs. +circulation_biomarker_diagnosis_ns 36561056 hsa-mir-21 Essential Hypertension CONCLUSIONS: Circulating serum levels of miR-21 are increased in elderly patients with EH with LA dilation. +exosome 36560694 hsa-mir-21 Influenza, Human Results: A change in the miRNA composition (miR3p, miR-26a-5p, miR-23a-5p, miR-548c-5p) and mRNA composition (RPL13A, MKNK2, TRIB3) of exosomes under the influence of the IAV was shown. +exosome 36560694 hsa-mir-548c Influenza, Human Results: A change in the miRNA composition (miR3p, miR-26a-5p, miR-23a-5p, miR-548c-5p) and mRNA composition (RPL13A, MKNK2, TRIB3) of exosomes under the influence of the IAV was shown. +exosome 36560694 hsa-mir-23a Influenza, Human Results: A change in the miRNA composition (miR3p, miR-26a-5p, miR-23a-5p, miR-548c-5p) and mRNA composition (RPL13A, MKNK2, TRIB3) of exosomes under the influence of the IAV was shown. +exosome 36560694 hsa-mir-26a Influenza, Human Results: A change in the miRNA composition (miR3p, miR-26a-5p, miR-23a-5p, miR-548c-5p) and mRNA composition (RPL13A, MKNK2, TRIB3) of exosomes under the influence of the IAV was shown. +other 36560686 hsa-mir-6741 COVID-19 In sum, we show that circulatory miR5p may serve as a prognostic biomarker effectively predicting mortality risk and LOS of hospitalized COVID-19 patients. +other 36559150 hsa-mir-126 Ischemia In endothelial cells, microRNA-126 (miR-126) promotes angiogenesis, and modulating the intracellular levels of this gene could suggest a method to treat cardiovascular diseases such as ischemia. +other 36558525 hsa-mir-28 Arthritis OL-EAE therapy significantly upregulated the expression of miR-28 and miR-199a. +other 36558525 hsa-mir-199a Arthritis OL-EAE therapy significantly upregulated the expression of miR-28 and miR-199a. +lncRNA target 36558243 hsa-mir-146a Inflammation Our previous studies demonstrated that cerium oxide nanoparticles (CNPs) conjugated with therapeutic microRNA146a (miR146a) could effectively enhance wound healing by targeting the NFkappaB pathway, reducing oxidative stress and inflammation. +other 36556492 hsa-mir-16 Colorectal Neoplasms 5p, and miR-27a-3p in the colonic mucosa of CRC patients. +other 36556492 hsa-mir-27a Colorectal Neoplasms 5p, and miR-27a-3p in the colonic mucosa of CRC patients. +other 36556492 hsa-mir-195 Colorectal Neoplasms 5p, and miR-27a-3p in the colonic mucosa of CRC patients. +other 36556492 hsa-mir-107 Colorectal Neoplasms 5p, and miR-27a-3p in the colonic mucosa of CRC patients. +other 36556329 hsa-mir-24 COVID-19 Some miRNAs, including miR3p, whose differential expression was discovered in patients with acute lung injury complications brought on by severe COVID-19, and miR-148a-3p, differentially expressed against SARS-CoV-2 structural proteins, were identified, thereby suggesting the effectiveness and accuracy of our framework. +other 36556329 hsa-mir-148a COVID-19 Some miRNAs, including miR3p, whose differential expression was discovered in patients with acute lung injury complications brought on by severe COVID-19, and miR-148a-3p, differentially expressed against SARS-CoV-2 structural proteins, were identified, thereby suggesting the effectiveness and accuracy of our framework. +genetics_knock down_suppress 36556251 hsa-mir-92b Bone Diseases Exosomal miR-92b-3p secreted from MVECs under mechanical unloading has been shown for the first time to partially attenuate the function of osteoblasts through downregulation of ELK4, suggesting a potential strategy to protect against the mechanical unloading-induced bone loss and disuse osteoporosis. +genetics_knock down_suppress 36556251 hsa-mir-92b Osteoporosis Exosomal miR-92b-3p secreted from MVECs under mechanical unloading has been shown for the first time to partially attenuate the function of osteoblasts through downregulation of ELK4, suggesting a potential strategy to protect against the mechanical unloading-induced bone loss and disuse osteoporosis. +circulation_biomarker_diagnosis_up 36556238 hsa-mir-1296 Thyroid Cancer, Papillary Taken together, our findings suggested that circulating exosomal miRNAs, particularly miR +transcription factor target 36555553 hsa-mir-503 Head and Neck Neoplasms Overall, this study demonstrates that miR-503 suppresses HNC malignancy by inhibiting cell invasion through the Wnt signaling pathway via the WNT3A/MMP molecular axis. +target gene 36555545 hsa-mir-1 Carcinoma, Hepatocellular Thymoquinone Suppresses Angiogenesis in DEN-Induced Hepatocellular Carcinoma by Targeting miR-1-3p. +other 36555437 hsa-mir-19 Obesity We observed that miR-19s were upregulated in the abdominal subcutaneous adipose tissue (aSAT) of human patients with morbid obesity, whereas after bariatric surgery, their expression was reduced. +other 36555437 hsa-mir-19a Obesity Here, we show the relevance of the miR-19 family, miR-19a and miR-19b, in lipid accumulation and the expansion of the adipose tissue in obesity. +other 36555437 hsa-mir-19b Obesity Here, we show the relevance of the miR-19 family, miR-19a and miR-19b, in lipid accumulation and the expansion of the adipose tissue in obesity. +other 36555437 hsa-mir-19 Obesity, Morbid We observed that miR-19s were upregulated in the abdominal subcutaneous adipose tissue (aSAT) of human patients with morbid obesity, whereas after bariatric surgery, their expression was reduced. +lncRNA target 36555418 hsa-mir-193b Muscular Diseases As a well-known cancer-related miRNA, miR-193b-3p is enriched in skeletal muscle and dysregulated in muscle disease. +transcription factor target 36555301 hsa-mir-200c Cardiovascular Diseases In conclusion, downregulated miR-200c-3p in T1DM correlated with diabetic control, VEGF signaling, inflammation, vascular health and targeting VEGF signaling, and may define subclinical CVD. +lncRNA target 36553675 hsa-mir-122b Oropharyngeal Neoplasms Our data suggest, for the first time, that ADAM3A and ADAM5 pseudogene-inherited CNV could modulate OPSCC occurrence and prognosis, possibly through the interaction of ADAM5 pseudogene transcript, miR-122b-5p, and ADAM9. +lncRNA target 36553610 hsa-mir-181c Carcinoma, Hepatocellular The functional enrichment bioinformatics analyses of miR-181c-5p-downregulated targets in HCC indicated that miR-181c-5p targets were significantly enriched in multiple pathways and biological processes involved in HCC development. +circulation_biomarker_diagnosis_ns 36553586 hsa-mir-375 Prostatic Neoplasms Plasma and exosomes were obtained from 34 patients with PCa and 34 patients with BPH, and their levels of expression of miR-21 and miR-375 were determined by RT-qPCR. +circulation_biomarker_prognosis_up 36553586 hsa-mir-21 Prostatic Neoplasms The level of exosomal miR-21 was elevated in PCa patients with high serum PSA values, as well as in patients with aggressive PCa, while for plasma samples, the results remained insignificant. +genetics_overexpression_promote 36553522 hsa-mir-664a Carcinoma, Hepatocellular Alcohol Dehydrogenase 4 (ADH4) is a well-known prognostic protein biomarker for predicting the survival outcomes of patients with hepatocellular carcinoma whose expression is regulated by miR-664a-3p, which is upregulated in HCC. In summary, our interaction analyses results predict the significance of the MEG3/miR-664a-3p/ADH4 axis, where MEG3 downregulation results in miR-664a-3p overexpression and the subsequential underexpression of ADH4 in HCC, as a novel axis of interest that demands further validation. +other 36553468 hsa-mir-1268a Liver Diseases 3p, which might play roles in hepatic fibrosis. +transcription factor target 36552896 hsa-mir-130a Non-alcoholic Fatty Liver Disease MBOAT2 (membrane-bound O-acyltransferase domain containing 2) was directly targeted by miR-130a-5p, which was downregulated in the liver of NAFLD laying hens but reversed after L. salivarius SNK-6 alleviated liver damage partly via the miR-130a-5p/MBOAT2 signaling pathway. +circulation_biomarker_diagnosis_up 36552891 hsa-mir-19b Lupus Erythematosus, Systemic After isolation of peripheral blood mononuclear cells (PBMC) from the SLE group and healthy group and treatment of SLE-derived PBMCs with UC-BSC-derived exosomes, the mRNA levels of corresponding factors in cells under different treatments were determined by RT-PCR, Th17/Treg content was analyzed by FCM (flow cytometry), and the targeted binding of microRNA-19b (miR-19b) to KLF13 was identified by in vitro experiments and bioinformatics analysis. According to the study's findings, SLE patients have dysregulated expression of the genes miR-19b and KLF13, and UC-BSC exosomes could regulate Th17/Treg cell balance and inflammatory factor expression in SLE patients through miR-19b/KLF13. +other 36552749 hsa-mir-143 Heart Failure A total of 123 relatively specifically expressed miRNAs were screened; among these, the miRNAs associated with HF development such as miR-143, miR-214, miR-125b, miR-31, and miR-200 were presented. +other 36552749 hsa-mir-1 Heart Failure A total of 123 relatively specifically expressed miRNAs were screened; among these, the miRNAs associated with HF development such as miR-143, miR-214, miR-125b, miR-31, and miR-200 were presented. +other 36552749 hsa-mir-214 Heart Failure A total of 123 relatively specifically expressed miRNAs were screened; among these, the miRNAs associated with HF development such as miR-143, miR-214, miR-125b, miR-31, and miR-200 were presented. +other 36552749 hsa-mir-125b Heart Failure A total of 123 relatively specifically expressed miRNAs were screened; among these, the miRNAs associated with HF development such as miR-143, miR-214, miR-125b, miR-31, and miR-200 were presented. +other 36552749 hsa-mir-200 Heart Failure A total of 123 relatively specifically expressed miRNAs were screened; among these, the miRNAs associated with HF development such as miR-143, miR-214, miR-125b, miR-31, and miR-200 were presented. +transcription factor target 36552609 hsa-mir-137 Diabetes Mellitus This study presents a new therapeutic target for managing type I diabetes using miR-137 and miR-29b. +transcription factor target 36552609 hsa-mir-29b Diabetes Mellitus This study presents a new therapeutic target for managing type I diabetes using miR-137 and miR-29b. +exosome 36551866 hsa-mir-210 Endometriosis The expression of miR3p was increased in both exosomes and the eutopic endometrium in patients with endometriosis through miRNA sequencing, which could also reduce the proportion of CD80(+) macrophages. +lncRNA target 36551768 hsa-mir-186 Osteosarcoma Furthermore, circDOCK1 upregulated DNMT3A expression through sponging miR-186 to regulate the progression of OS. CONCLUSIONS: CircDOCK1 promotes OS progression by interacting with miR-186/DNMT3ADNMT3A, representing a novel therapeutic approach. +other 36551704 hsa-mir-335 Adenocarcinoma of Lung A ceRNA network of KCNQ1OT1/miR5p/DMRT3 was constructed in LUAD. +other 36551202 hsa-mir-126 Non-alcoholic Fatty Liver Disease NAFLD+LOLA+VitE decreased miR-122, miR-33a and miR-186, and increased miR-126 (p < 0.05, for all) in comparison to NAFLD and NAFLD+VitE. +exosome 36551009 hsa-mir-451 Prostatic Neoplasms We were able to successfully detect specific exosomal miRNAs (exomiRs) in the urine of patients with prostate cancer, including exomiR-451 and exomiR-21, and used electrochemistry for measurement and analysis. +exosome 36551009 hsa-mir-21 Prostatic Neoplasms We were able to successfully detect specific exosomal miRNAs (exomiRs) in the urine of patients with prostate cancer, including exomiR-451 and exomiR-21, and used electrochemistry for measurement and analysis. +genetics_knock down_promote 36550594 hsa-mir-942 Glioma LINC01018 knockdown and miR +genetics_overexpression_promote 36550514 hsa-mir-204 Arthritis, Rheumatoid 5p, and its overexpression rescued the repressive impact of miR +other 36550370 hsa-mir-158 Mycoses Eight miRNAs which belonged to the conserved miRNA families and were known to be induced in response to fungal diseases in plants included the following: miR156, miR158, miR159, miR168, miR169, miR172, miR319, miR396. +other 36550370 hsa-mir-156 Mycoses Eight miRNAs which belonged to the conserved miRNA families and were known to be induced in response to fungal diseases in plants included the following: miR156, miR158, miR159, miR168, miR169, miR172, miR319, miR396. +lncRNA target 36550153 hsa-mir-20a Quadruple Negative Breast Cancer miRNA-mRNAs which include FOXA1 and MYC (mir-17/20a targets); GATA3 and CCNG2 (mir-135b targets); CDKN2A, CDK6, and B7-H3 (mir-29c targets); and RUNX3, KLF5, IL1-beta, and CTNNB1 (mir-375 targets) were correlated with basal-like and immune subtypes in QNBC patients and associated with a worse survival. +lncRNA target 36550153 hsa-mir-375 Quadruple Negative Breast Cancer miRNA-mRNAs which include FOXA1 and MYC (mir-17/20a targets); GATA3 and CCNG2 (mir-135b targets); CDKN2A, CDK6, and B7-H3 (mir-29c targets); and RUNX3, KLF5, IL1-beta, and CTNNB1 (mir-375 targets) were correlated with basal-like and immune subtypes in QNBC patients and associated with a worse survival. +lncRNA target 36550153 hsa-mir-17 Quadruple Negative Breast Cancer miRNA-mRNAs which include FOXA1 and MYC (mir-17/20a targets); GATA3 and CCNG2 (mir-135b targets); CDKN2A, CDK6, and B7-H3 (mir-29c targets); and RUNX3, KLF5, IL1-beta, and CTNNB1 (mir-375 targets) were correlated with basal-like and immune subtypes in QNBC patients and associated with a worse survival. +lncRNA target 36550153 hsa-mir-135b Quadruple Negative Breast Cancer miRNA-mRNAs which include FOXA1 and MYC (mir-17/20a targets); GATA3 and CCNG2 (mir-135b targets); CDKN2A, CDK6, and B7-H3 (mir-29c targets); and RUNX3, KLF5, IL1-beta, and CTNNB1 (mir-375 targets) were correlated with basal-like and immune subtypes in QNBC patients and associated with a worse survival. +lncRNA target 36550153 hsa-mir-29c Quadruple Negative Breast Cancer miRNA-mRNAs which include FOXA1 and MYC (mir-17/20a targets); GATA3 and CCNG2 (mir-135b targets); CDKN2A, CDK6, and B7-H3 (mir-29c targets); and RUNX3, KLF5, IL1-beta, and CTNNB1 (mir-375 targets) were correlated with basal-like and immune subtypes in QNBC patients and associated with a worse survival. +lncRNA target 36550019 hsa-mir-490 Carcinoma, Non-Small-Cell Lung CONCLUSION: Hsa_circ_0092887 depletion alleviated PTX-resistance in NSCLC cells via modulating the miR +other 36549862 hsa-mir-92 Heart Failure Strikingly, two of these miRs (miR-21 and miR-92) were significantly reduced in HFpEF patients after the 3-month treatment with empagliflozin, whereas no significant differences in the profile of endothelial miRs were detected in patients treated with metformin or insulin. +other 36549862 hsa-mir-21 Heart Failure Strikingly, two of these miRs (miR-21 and miR-92) were significantly reduced in HFpEF patients after the 3-month treatment with empagliflozin, whereas no significant differences in the profile of endothelial miRs were detected in patients treated with metformin or insulin. +circulation_biomarker_diagnosis_ns 36549775 hsa-mir-377 Acute Coronary Syndrome The serum miR-377 level was elevated in the ACS patients and significantly increased in the ACS rats. +circulation_biomarker_diagnosis_ns 36549765 hsa-mir-338 Respiratory Distress Syndrome, Newborn Pearson's correlation analysis evaluated the correlation between serum miR +circulation_biomarker_diagnosis_ns 36549765 hsa-mir-338 Respiratory Distress Syndrome Pearson's correlation analysis evaluated the correlation between serum miR +other 36549352 hsa-mir-29a Pulmonary Fibrosis The current study investigated the ability of THY to modulate oxidative stress, inflammation, miR-29a/TGF-beta expression, and PI3K/phospho-Akt signaling in lung fibrosis. +target gene 36548909 hsa-mir-216b Stomach Neoplasms LncRNA-SNHG1 promotes paclitaxel resistance of gastric cancer cells through modulating the miR-216b-5p-hexokianse 2 axis. +exosome 36548450 hsa-mir-124 Cerebral Hemorrhage In conclusion, ICH-exos delivered lncRNA SND1-IT1 to HMC3 cells, and exosomal lncRNA SND1-IT1 can regulate cell viability and apoptosis to influence HMC3 cell growth via the SND1-IT1/miR3p/MTF1 axis. +lncRNA target 36548440 hsa-mir-1250 Triple Negative Breast Neoplasms 5p acts as tumor suppressor in TNBC cells and its induction by therapeutics might be a novel strategy for the disease treatment. +genetics_overexpression_promote 36546770 hsa-mir-143 Colonic Neoplasms overexpressing cells restored 5-FU resistance of CRC cells. +other 36546578 hsa-mir-21 Endometriosis Additionally, a negative correlation of METTL3 was identified with miR5p along with a positive correlation with the WIF1 mRNA in EM tissues. +genetics_overexpression_suppress 36545728 hsa-mir-31 Melanoma Overexpression of miR +exosome 36545680 hsa-mir-449a Osteosarcoma Our findings not only reveal a novel mechanism of miR-449a /CCNB1 in OS but also had laid the groundwork for further investigation and analysis in the field of exosome engineering. +lncRNA target 36545127 hsa-mir-642a Colonic Neoplasms Analysis of the potential upstream miRNA of MACC1 showed that miR-642a-5p was downregulated in COAD and was negatively correlated with MACC1 expression. In summary, these findings suggest that MACC1 contributes to COAD progression and immune cell infiltration via the ZFAS1/miR-642a-5p/MACC1 axis. +genetics_overexpression_suppress 36544920 hsa-mir-1 Squamous Cell Carcinoma of Head and Neck COL5A1 overexpression reversed the inhibitory effects of miR +lncRNA target 36544854 hsa-mir-124 Inflammation An ameliorative action of Pio was demonstrated via decreased CD86 immunoexpression, upregulation of miRNA-124, decreased STAT3 expression and beneficial anti-inflammatory effects. Pio exerted its anti-inflammatory effects via PPARgamma/miRNA-124/STAT3 signaling. +other 36544782 hsa-mir-128 Carcinoma, Non-Small-Cell Lung 3p for participating in LUSC progression. +other 36544695 hsa-mir-23b Squamous Cell Carcinoma of Head and Neck Finally, a ceRNA network (SMS/hsa-miR-23b-3p/KTN1-AS1 and VPS9D1-AS axis) was constructed based on the co-expression and survival analyses in HNSC. +target gene 36544654 hsa-mir-200a Neuroblastoma Corin is regulated by circ-0012397/miR-200a-3p and inhibits the oxygen-glucose deprivation-induced apoptosis of SHSY5Y neuroblastoma cells. +transcription factor target 36544422 hsa-mir-204 Fetal Growth Retardation CONCLUSIONS: Inhibiting miR-204 can improve the learning and memory functions of neonatal rats with IUGR, possibly by targeted activation of the BDNF/TrkB signaling pathway. +lncRNA target 36544170 hsa-mir-200a Osteosarcoma CONCLUSION: LncEBLN3P is upregulated in osteosarcoma and increases the MTX resistance in osteosarcoma cells through downregulating miR-200a-3p, which in turn promoted the EMT process of osteosarcoma cells by increasing the OGT. +other 36543894 hsa-let-7b Acute Kidney Injury Let-7b-5p downregulation may lead to increased renal AKI susceptibility, thus indicating that this miRNA is a potential driver of the MSC treatment response in AKI. +lncRNA target 36543302 hsa-mir-181a Carcinoma, Non-Small-Cell Lung CONCLUSIONS: In summary, our study demonstrates that LINC01232 expression increases in LUSC tissues and cell lines and promotes LUSC progression by modulating the miR-181a-5p/SMAD2 signaling, providing new potential drug targets for LUSC treatment. +lncRNA target 36542990 hsa-mir-200c Colorectal Neoplasms Mechanistically, we proved that circ-ZEB1 could directly bind with miR-200c and functioned as miR-200c sponge to exert its biological functions in CRC cells. In conclusion, circ-ZEB1 could promote CRC cells progression, EMT, and chemoresistance via acting on miR-200c, elucidating a potential therapeutic target to inhibit CRC progression. +other 36542459 hsa-mir-19 Breast Neoplasms Collectively, these results demonstrated, for the first time, that SFN regulates the miR-19/PTEN axis to exert protective effects against BBP-mediated breast cancer promotion, suggesting a new potential role for SFN (or SFN-rich foods) in phthalate antagonism. +other 36542326 hsa-mir-149 Pituitary Neoplasms dependent expression of ADAM12 and MMP-14. +circRNA target 36542208 hsa-mir-362 Colorectal Neoplasms HMGB3 acted as a downstream target for miR +transcription factor target 36541921 hsa-mir-124 Memory Disorders It is possible that miRNA-124 can be used as a new target for the pathogenesis of memory impairment, including age-associated neurodegenerative diseases such as Alzheimer's disease. +lncRNA target 36541900 hsa-mir-212 Pulmonary Disease, Chronic Obstructive In conclusion, LINC00599 facilitated CSE-induced cell apoptosis and inflammation response, while inhibiting the cell viability and proliferation in COPD progression via modulating miR +other 36541451 hsa-mir-24 Pneumothorax In conclusion, the miRNA-24 levels were significantly decreased in children with PSP. +other 36541451 hsa-mir-21 Pneumothorax In conclusion, the miRNA-24 levels were significantly decreased in children with PSP. +circulation_biomarker_diagnosis_up 36541422 hsa-mir-146b Pre-Eclampsia There are a variety of abnormal expression miRNAs in PE, however, the relationship between miR-146b-5p and PE has yet to be fully elucidated.What do the results of this study add? We first found that expression levels of serum miR-146b-5p in the first trimester were significantly higher in PE than in a normal pregnancy group. +genetics_knock down_suppress 36541402 hsa-mir-545 Pancreatic Neoplasms Circ_0018909 knockdown inhibits the development of pancreatic cancer via the miR-545-3p/FASN axis and reduces macrophage polarization to M2. +genetics_GWAS 36541377 hsa-mir-4513 Coronary Disease This study was designed to determine the possible association of miRNA polymorphisms (miRNA-146a rs2910164C/G and miR-4513 rs2168518G/A) with susceptibility to CHD in Egyptian patients and their correlation with different biochemical parameters. The present study's findings indicated that the selected polymorphisms, miR-146a rs2910164 and miR-4513 rs2168518 could represent a useful biomarker for susceptibility to CHD in the Egyptian population. +genetics_GWAS 36541377 hsa-mir-146a Coronary Disease This study was designed to determine the possible association of miRNA polymorphisms (miRNA-146a rs2910164C/G and miR-4513 rs2168518G/A) with susceptibility to CHD in Egyptian patients and their correlation with different biochemical parameters. The present study's findings indicated that the selected polymorphisms, miR-146a rs2910164 and miR-4513 rs2168518 could represent a useful biomarker for susceptibility to CHD in the Egyptian population. +lncRNA target 36541217 hsa-mir-34a Fatty Liver Taken together, ATM is a promising therapeutic agent against MAFLD that reduces lipid deposition by suppressing miR-34a-5p and upregulating PPARalpha. +lncRNA target 36541023 hsa-mir-144 Periprosthetic Fractures 3p/RUNX1 pathway may provide a potential target for prevention of PPOL. +other 36540394 hsa-mir-155 COVID-19 However, the relationships between TLR-4 and miR-155 are more specific in discriminating against COVID-19 patients with and without diabetes. +other 36540394 hsa-mir-155 Periodontitis However, the relationships between TLR-4 and miR-155 are more specific in discriminating against COVID-19 patients with and without diabetes. +other 36540394 hsa-mir-155 Diabetes Mellitus However, the relationships between TLR-4 and miR-155 are more specific in discriminating against COVID-19 patients with and without diabetes. +other 36540376 hsa-mir-137 Alzheimer Disease Furthermore, AD induction was performed by aluminum chloride (Alcl(3)), animals were allocated, and brain hippocampus tissue was isolated for ELISA and qRT-PCR analysis of malondialdehyde (MDA), nuclear factor kappa B (NF-kB), and microRNA-137 (miR-137) coupled with immunohistochemical amyloid-beta (Abeta(1-)42) expression and histopathological finding. +other 36540097 hsa-mir-582 Myocardial Infarction 5p/F2RL2 axis, providing novel biomarkers for MI treatment. +genetics_knock down_promote 36540014 hsa-mir-142 Osteoarthritis 5p reversed the suppressive effects of circ-NT5C2 silencing on the OA progression in vitro, and NAMPT overexpression also attenuated the effects of miR +circulation_biomarker_prognosis_ns 36540006 hsa-mir-146a Lymphoma, Large B-Cell, Diffuse This study aims to explore the role of serum miR-146a in predicting the prognosis of DLBCL. CONCLUSION: Our results suggest that the level of serum miR-146a can serve as a potential prognostic biomarker for DLBCL patients. +other 36539984 hsa-mir-21 Lung Neoplasms Intriguingly, microRNA-21, an early marker of lung cancer, can be detected without being transcribed in advance by an innovative signal amplification strategy using ferritin-mediated aggregation of hydrophilic nitroxide radical monomers as an electrochemical biosensor. +lncRNA target 36539807 hsa-mir-194 Carcinoma, Pancreatic Ductal 5p/SOCS2 axis may be a potential therapeutic target for PDAC patients. +genetics_knock down_promote 36539702 hsa-mir-338 Colorectal Neoplasms CONCLUSION: This study demonstrated that circ_0039857 knockdown suppressed CRC malignant progression through miR3p/RAB32 axis. +genetics_knock down_promote 36539576 hsa-mir-492 Breast Neoplasms Over-expression of miR5p or miR-492, therefore, induces pre-neoplastic phenotypes similar to those reported upon Cx43 loss, and may act as oncomiRs and possible biomarkers of increased breast cancer risk. +genetics_knock down_promote 36539576 hsa-mir-183 Breast Neoplasms Over-expression of miR5p or miR-492, therefore, induces pre-neoplastic phenotypes similar to those reported upon Cx43 loss, and may act as oncomiRs and possible biomarkers of increased breast cancer risk. +genetics_knock down_promote 36539576 hsa-mir-183 Precancerous Conditions Over-expression of miR5p or miR-492, therefore, induces pre-neoplastic phenotypes similar to those reported upon Cx43 loss, and may act as oncomiRs and possible biomarkers of increased breast cancer risk. +genetics_knock down_promote 36539576 hsa-mir-492 Precancerous Conditions Over-expression of miR5p or miR-492, therefore, induces pre-neoplastic phenotypes similar to those reported upon Cx43 loss, and may act as oncomiRs and possible biomarkers of increased breast cancer risk. +genetics_knock down_suppress 36539369 hsa-mir-644a Esophageal Neoplasms Besides that, inhibition of miR-644a abolished the promoting action of hsa_circ_0007380 knockdown on esophagus cancer apoptosis and radiosensitivity. +lncRNA target 36539368 hsa-mir-1253 Prostatic Neoplasms miR-1253 was a downstream molecule of circ-ABCC4, and circ-ABCC4 depletion-mediated anti-cancer impacts in PCa cells were partly counteracted by decreasing miR-1253 abundance. miR-1253 targeted SOX4 mRNA, and miR-1253 blocked PCa cell malignant phenotypes partly by targeting SOX4. +genetics_knock down_promote 36539367 hsa-mir-582 Urinary Bladder Neoplasms 5p targeted KPNA2, and KPNA2 overexpression counteracted the inhibitory impact of miR +lncRNA target 36539365 hsa-mir-338 Carcinoma, Non-Small-Cell Lung Silencing of circPIM3 suppressed Tax resistance in Tax-resistant NSCLC cells through regulation of the miR3p/TNFAIP8 axis. +genetics_knock down_promote 36539364 hsa-mir-1299 Carcinoma, Non-Small-Cell Lung MiR-1299 was a target of circ_0058608, and the effects of circ_0058608 knockdown on NSCLC cell progression and taxol resistance were reversed by miR-1299 inhibition. +other 36539363 hsa-mir-451a Laryngeal Neoplasms At the same time, miR-451a was found to be the most significantly downregulated miRNA in laryngeal squamous cell carcinoma tissues. +transcription factor target 36539014 hsa-mir-19 Cardiomyopathies The present study aimed to verify the effects of miR-19 on cardiac fibrosis and its target. CONCLUSIONS: Upregulating miR-19 can improve cardiac function and attenuate cardiac fibrosis by inhibiting the CTGF and MAPK pathways. +lncRNA target 36539001 hsa-mir-142 Breast Neoplasms This study suggests that GNB2 is an essential target for miR +lncRNA target 36538851 hsa-mir-515 Osteoarthritis CONCLUSION: FTO alleviated OA in an m6A-dependent manner via the miR5p/TLR4/MyD88/NF-kappaB axis. +other 36538560 hsa-mir-155 Osteoarthritis As the micro-RNA miR-155 has been found increased in OA chondrocytes, we investigated the effects of high pressure on the expression of the miR-155 host gene Mir155hg. +lncRNA target 36538560 hsa-mir-155 Cartilage Diseases The chondrocyte progenitor cell line ATDC5 was pressurized under hydrostatic pressure up to 25 MPa and the expression of Mir155hg or the resulting micro-RNAs were measured; pharmacological inhibitors were used to identify the signaling pathways involved in the regulation of Mir155hg. +genetics_GWAS 36538546 hsa-mir-20a Polycystic Kidney Diseases We compared the relative expression profile of miR-20a, -192, -365, -15b-5p, and 5p from plasma and serum samples of nine domestic cats with PKD1 mutation, detected by polymerase chain reaction (PCR), and a control group (n = 10). +lncRNA target 36538280 hsa-mir-576 Endometrial Neoplasms 5p promoted proliferation and metastasis capacity of EC cells by inhibiting ZBTB4 expression. +circRNA target 36538242 hsa-mir-135a Urinary Bladder Neoplasms Mechanically, circSTK39 could sponge with miR-135a-5p, thus inhibiting NR3C2-mediated EMT processes in the BCa progression. In conclusion, our results revealed that circSTK39 inhibited EMT of BCa cells through the miR-135a-5p/NR3C2 axis and may provide promising biomarkers for the diagnosis or prospective therapeutic targets for BCa. +transcription factor target 36538194 hsa-mir-155 Meningioma The findings suggest that miR5p play an important role in the pathogenesis of meningioma and may represent potential therapeutic targets for its anti-PD-L1 immunotherapy. +circulation_biomarker_diagnosis_ns 36538076 hsa-mir-138 Acute Lung Injury Here, we discovered that an increased cytoplasmic mtDNA content in sepsis-induced ALI models induced the methylation of the miR +circulation_biomarker_diagnosis_ns 36538076 hsa-mir-138 Sepsis Here, we discovered that an increased cytoplasmic mtDNA content in sepsis-induced ALI models induced the methylation of the miR +lncRNA target 36537157 hsa-mir-9 Acute Lung Injury 5 p in ALI via regulating macrophage polarization. +other 36537124 hsa-mir-4640 Osteoarthritis 5p/NOTCH2 axis stimulates the Notch pathway to promote the transcription of inflammatory cytokines (IL33, IL17F and IL6), consequently facilitating OA progression in murine chondrocytes. +circulation_biomarker_prognosis_ns 36537076 hsa-mir-3201 Carcinoma, Hepatocellular Conclusions: Blood miR-3201 could be used as a prognostic biomarker for curative therapy response and OS in HCC. +transcription factor target 36536941 hsa-mir-186 Atherosclerosis CONCLUSION: In conclusion, the current findings suggest that dysregulated miR5p in AMI-Exo may explain the contribution of acute ischemia events to the advancement of atherosclerosis by enhancing macrophage foaming via its target, LOX-1. +transcription factor target 36536941 hsa-mir-186 Myocardial Infarction, Acute CONCLUSION: In conclusion, the current findings suggest that dysregulated miR5p in AMI-Exo may explain the contribution of acute ischemia events to the advancement of atherosclerosis by enhancing macrophage foaming via its target, LOX-1. +other 36536870 hsa-mir-145 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: miRNA-145 is significantly altered in OSCC in our patient population and its reduced values carry a poor prognosis. +other 36536516 hsa-mir-28 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma CONCLUSION: PUM2 plays as a novel oncogenic RBP in T-ALL by competitively binding to RBM5 mRNA with miR5p. +genetics_knock down_promote 36536496 hsa-mir-1179 Pancreatic Carcinoma Moreover, the miR-1179 inhibitor reversed the regulation of circ_0000284 knockdown on PC cell progression. +other 36536183 hsa-mir-122 Celiac Disease 3p was significantly increased in CD patients relative to control subjects (p = 0.049). +transcription factor target 36536183 hsa-mir-197 Celiac Disease Increased expression of miR3p with a final protective effect on Occludin expression can be further studied as a complement therapeutic target for Celiac disease. +transcription factor target 36535956 hsa-mir-126 Carcinoma, Hepatocellular 5p, one of the tumor-suppressive genes commonly decreased in HCC, was found negatively expressed and correlated with SNRPF1, and a specific region of SNRPF1 transcript is directly binding to miR +other 36535942 hsa-mir-378 Pancreatic Carcinoma The autophagy-related miR-378i and miR-378a-3p were selected as the top upregulated candidates, and their high expression in PDAC patient tissue correlated with low survival. +other 36535942 hsa-mir-378a Pancreatic Carcinoma The autophagy-related miR-378i and miR-378a-3p were selected as the top upregulated candidates, and their high expression in PDAC patient tissue correlated with low survival. +circRNA target 36535407 hsa-mir-495 Leukemia 3p expression is important in the malignant phenotype of CML and TKI resistance mechanisms and could be a useful biomarker and a potential therapeutic target to eradicate CML. +target gene 36535369 hsa-mir-486 Immunoglobulin G4-Related Disease Id4 modulates salivary gland homeostasis and its expression is downregulated in IgG4-related disease via miR-486-5p. +circulation_biomarker_diagnosis_ns 36535313 hsa-mir-133a Diabetes Mellitus, Type 2 So, this study examined the effects of eight weeks combination of 250 mg of UA per day per kilogram of body weight of rat as well as resistance/endurance training on miR-133a expression across serum, bone marrow, skeletal muscle, and Connexin 43 (Cx43)-Runt-related transcription factor 2 (Runx2) signaling axis in high-fat diet and low-dose streptozotocin-induced T2D (here, HFD/STZ-induced T2D). In conclusion, only eight weeks of resistance-type exercise could affect miR-133a profile in muscles and osteoblast differentiation biomarker RUNX2 in aged T2D model of rats. +other 36535134 hsa-mir-124 Brain Ischemia 3p and Nrep level in the MCAO model were found to be lower in the model predicted by bioinformatics than in the sham-operated group. +genetics_overexpression_promote 36535076 hsa-mir-181b Colorectal Neoplasms To elucidate the influence of CAFs-derived exosome miR-181b-3p on CRC, we overexpressed and knocked down the miR-181b-3p expression in CAFs, respectively. +exosome 36535010 hsa-mir-485 Pancreatic Carcinoma 3p by exosomes or some other vehicle might be a novel approach for PC treatment. +circulation_biomarker_diagnosis_up 36534156 hsa-mir-199a Hirschsprung Disease Plasma exosomal miR-199a-3p, a diagnostic marker, is crucial for the development of HSCR. +circulation_biomarker_prognosis_ns 36533956 hsa-mir-192 Esophageal Squamous Cell Carcinoma Plasma miR5p could be used as a predictor of response to chemotherapy and prognosis in EC patients. +lncRNA target 36533778 hsa-mir-19a Pre-Eclampsia Our results elucidated that circ_0004904 reduced proliferation and cell motility of trophoblast cells via the miR-19a-3p-mediated GADD45A level elevation, indicating the involvement of circ_0004904/miR-19a-3p/GADD45A in PE progression. +target gene 36533720 hsa-mir-136 Esophageal Squamous Cell Carcinoma CircRNA PDE3B regulates tumorigenicity via the miR-136-5p/MAP3K2 axis of esophageal squamous cell carcinoma. +genetics_overexpression_promote 36533591 hsa-mir-125b-2 Hypertension, Pulmonary 3p were downregulated in PVEC-derived exosomes of the IUGR group, which were associated with overexpression of FoxM1 and more significant proliferation and migration of PASMCs. +genetics_overexpression_promote 36533591 hsa-mir-214 Hypertension, Pulmonary 3p were downregulated in PVEC-derived exosomes of the IUGR group, which were associated with overexpression of FoxM1 and more significant proliferation and migration of PASMCs. +genetics_overexpression_promote 36533591 hsa-mir-326 Hypertension, Pulmonary 3p were downregulated in PVEC-derived exosomes of the IUGR group, which were associated with overexpression of FoxM1 and more significant proliferation and migration of PASMCs. +lncRNA target 36531954 hsa-mir-155 Intervertebral Disc Degeneration We also constructed a potentially dysregulated competing endogenous RNA (ceRNA) network between mRNAs and miRNAs related to IDD based on microRNA target information and co-expression analysis of RNA profiles and identified 36 ceRNA axes including ZFP36/miR +lncRNA target 36531954 hsa-mir-185 Intervertebral Disc Degeneration We also constructed a potentially dysregulated competing endogenous RNA (ceRNA) network between mRNAs and miRNAs related to IDD based on microRNA target information and co-expression analysis of RNA profiles and identified 36 ceRNA axes including ZFP36/miR +lncRNA target 36531954 hsa-mir-664a Intervertebral Disc Degeneration We also constructed a potentially dysregulated competing endogenous RNA (ceRNA) network between mRNAs and miRNAs related to IDD based on microRNA target information and co-expression analysis of RNA profiles and identified 36 ceRNA axes including ZFP36/miR +circulation_biomarker_prognosis_ns 36531335 hsa-mir-340 Carcinoma, Non-Small-Cell Lung CONCLUSION: The plasma levels of miR-340 combined with miR-450b-5p potentially define core biomarker signatures for improving the accuracy of NSCLC diagnosis. +circulation_biomarker_prognosis_ns 36531335 hsa-mir-450b Carcinoma, Non-Small-Cell Lung CONCLUSION: The plasma levels of miR-340 combined with miR-450b-5p potentially define core biomarker signatures for improving the accuracy of NSCLC diagnosis. +genetics_overexpression_suppress 36531016 hsa-mir-182 Mouth Neoplasms 5p (p < 0.0001) were significantly overexpressed, whereas miR-133b (p < 0.05) was significantly downregulated in OSCC tissues, a scenario confirmed in two additional OSCC validation cohorts: Regina Elena National Cancer Institute (IRE cohort, N=74) and The Cancer Genome Atlas Data Portal (TCGA cohort, N=354). +genetics_overexpression_suppress 36531016 hsa-mir-21 Mouth Neoplasms 5p (p < 0.0001) were significantly overexpressed, whereas miR-133b (p < 0.05) was significantly downregulated in OSCC tissues, a scenario confirmed in two additional OSCC validation cohorts: Regina Elena National Cancer Institute (IRE cohort, N=74) and The Cancer Genome Atlas Data Portal (TCGA cohort, N=354). +genetics_overexpression_suppress 36531016 hsa-mir-146b Mouth Neoplasms 5p (p < 0.0001) were significantly overexpressed, whereas miR-133b (p < 0.05) was significantly downregulated in OSCC tissues, a scenario confirmed in two additional OSCC validation cohorts: Regina Elena National Cancer Institute (IRE cohort, N=74) and The Cancer Genome Atlas Data Portal (TCGA cohort, N=354). +circulation_biomarker_diagnosis_up 36530488 hsa-mir-27a Liver Neoplasms The results showed that miR-27a-3p is downregulated in blood, cell lines, and tissues of HCC patients compared to normal controls. +target gene 36530029 hsa-mir-29a Liver Neoplasms miR-29a-5p regulates the malignant biological process of liver cancer cells through ARID2 regulation of EMT. +lncRNA target 36530027 hsa-mir-7 Femur Head Necrosis OBJECTIVES: To investigate whether circHIPK3 promotes bone microvascular activity and angiogenesis by targeting miR-7 and Kruppel-like factor 4 (KLF4)/vascular endothelial growth factor (VEGF) signaling in ONFH. +genetics_overexpression_suppress 36529892 hsa-mir-105 Carcinoma, Non-Small-Cell Lung Overexpression of FAM138B can inhibit the expression level of miR +genetics_overexpression_promote 36529430 hsa-mir-138 Glioma 5p repressed the glioma malignant phenotype and MeCP2 overexpression reversed the inhibitory effect of miR +lncRNA target 36529281 hsa-mir-133a Bloom Syndrome SIGNIFICANCE: These findings suggest that MALAT1 positively regulates RhoA protein expression by inhibiting miR-133a-3p in BSM cells, and that its upregulation causes the RhoA upregulation, resulting in an augmented BSM contractility. +other 36529281 hsa-mir-133a Asthma In BSMs of the murine asthma model, upregulations of Malat1 and RhoA protein were observed concomitantly with downregulation of miR-133a-3p. +tissue_expression_ns 36529101 hsa-mir-34a Anovulation In current experiment, we evaluated the function of miR-34a-5p on autophagy and apoptosis in chicken follicular atresia. First, the follicular atresia model of chicken was successfully constructed by subcutaneous injection of tamoxifen (TMX), and found the expression of miR-34a-5p in the atresia follicles obviously increased. +tissue_expression_ns 36529101 hsa-mir-34a Intestinal Atresia In current experiment, we evaluated the function of miR-34a-5p on autophagy and apoptosis in chicken follicular atresia. First, the follicular atresia model of chicken was successfully constructed by subcutaneous injection of tamoxifen (TMX), and found the expression of miR-34a-5p in the atresia follicles obviously increased. +lncRNA target 36529069 hsa-mir-193a Multiple Sclerosis Therefore, miR-193a and its associated targets could serve potential prognostic, diagnostic, and therapeutic efficacy in MS patients. +genetics_knock down_promote 36528986 hsa-mir-136 Carcinoma, Hepatocellular 5p re-expression inhibited HCC cell growth and metastasis, which was abated by KIAA1522 overexpression. +lncRNA target 36528556 hsa-mir-520c Squamous Cell Carcinoma of Head and Neck The expression of HOXA-AS2 was found to be negatively associated with miR-520c-3p in OSCC tissues. CONCLUSION: HOXA-AS2 served an oncogene and promoted OSCC progression via the miR-520c-3p/SNX5 axis. +lncRNA target 36527891 hsa-mir-483 Leukemia, Monocytic, Acute CONCLUSION: LncRNA NR2F1-AS1 affects the sensitivity of THP-1 cells to azacitidine resistance by regulating the miR3p/IGF1 axis, which may be a potential target for the treatment of acute monocytic leukemia. +lncRNA target 36527878 hsa-mir-140 Osteoarthritis, Knee 5p protects CPCs from fate changes via inhibiting Jagged1/Notch signaling in knee OA, providing attractive targets for OA therapeutics. +other 36527420 hsa-mir-183 Amyotrophic Lateral Sclerosis 5p and provides a molecular link between aberrant RNA processing and protein degradation, two major pillars in ALS pathogenesis. +lncRNA target 36527387 hsa-mir-139 Diabetes Mellitus 5p/HOXA9 might be an important therapeutic target in treating diabetic BMSCs and diabetic complications in the future. +other 36526091 hsa-mir-26b Diabetic Retinopathy 3p, which was not observed in the other models. +other 36526091 hsa-mir-122 Diabetic Retinopathy 3p, which was not observed in the other models. +lncRNA target 36525235 hsa-mir-424 Carcinoma, Endometrioid Rescue experiments further supported that lncRNA E27 inhibited proliferation, migration, invasion, and promoted apoptosis of endometrial cancer through miR-424/E2F6/E2F7 signaling axis. Conclusively, our findings revealed the role of lncRNA E27 in regulating the miR-424/E2F6/E2F7 signaling axis during EC progression, opening up new strategies for the treatment of endometrial cancer. +other 36524862 hsa-mir-144 Glaucoma CONCLUSION: Circ_0047835 might contribute to fibrosis progression after glaucoma surgery by regulating the miR3p/SP1 axis. +epigenetics 36524545 hsa-mir-1258 Carcinoma, Hepatocellular Systemic analysis and experimentally validation identified a ceRNA network (PVT1/miR-1258/DUSP13 axis) characterized by lipid regulatory potential, immune properties, and abnormal methylation states in patients with HCC and MVI. Furthermore, miR-1258 was an independent predictor for MVI in patients with HCC. +circRNA target 36524450 hsa-mir-199b Carcinoma, Hepatocellular MiR-199b-5p suppressed HCC progression by inhibiting STRN expression. +other 36524359 hsa-mir-3065 Carcinoma, Hepatocellular ZFPM2AS1 regulates XRCC4 by sponging miR30655p to promote GS and HCC progression. +epigenetics 36524356 hsa-mir-378a IMAGe syndrome The SUFU gene promoter remained unmethylated in all tissue samples, while miR2143p and miR378a5p were downregulated in IUGR. +circulation_biomarker_diagnosis_ns 36524216 hsa-mir-193a Keloid The hsa_circ_0020792 and miR-193a-5p levels in keloid patient-Exo and healthy control-Exo, as well as in keloid fibroblasts and normal skin fibroblasts (NFs) were evaluated by RT-qPCR. CONCLUSION: Collectively, keloid patient plasma-derived exosomal hsa_circ_0020792 could promote the proliferation, migration, and fibrogenesis of NFs via modulating miR-193a-5p and activating TGF-beta1/Smad2/3 signaling. +exosome 36524211 hsa-mir-503 Glioma Herein, the aim of the current investigation was to explore the functional role of mesenchymal stem cells (MSCs)-derived extracellular vesicles (EVs) containing miR-503 in glioma. +lncRNA target 36524095 hsa-mir-193b Cardiomegaly Here, the mechanism of action of the lncRNA terminal differentiation-induced non-coding RNA (TINCR), miR-193b-3p, and RAR-related orphan receptor A (RORA) mRNA was analyzed in an angiotensin (Ang) II-induced H9C2 cardiomyocyte hypertrophy model treated with QYDP. CONCLUSIONS: Administration of QYDP improves Ang II-induced H9C2 cardiomyocyte hypertrophy and increase cell proliferation rate through the TINCR/miR-193b-3p/RORA axis. +lncRNA target 36523634 hsa-mir-199a Respiratory Distress Syndrome The agomirs or antagomirs of MiR-199a-3p were injected into the caudal vein to figure out whether MiR-199a-3p could influence ARDS inflammation and lung injury, whereas the mimics or inhibitors of MiR-199a-3p, siRNA of Rab8a, or PAK4 inhibitor were transfected or applied to RAW264.7 cells to evaluate the mechanism of SAP release. +other 36523600 hsa-mir-92b Polycystic Ovary Syndrome BRCA1, LDLR, MAP1B, hsa-miR-92b-3p, hsa-miR-20b-5p, and NEAT1 might play a considerably important role in PCOS dysfunction. +other 36523600 hsa-mir-20b Polycystic Ovary Syndrome BRCA1, LDLR, MAP1B, hsa-miR-92b-3p, hsa-miR-20b-5p, and NEAT1 might play a considerably important role in PCOS dysfunction. +other 36523511 hsa-mir-149 Carcinoma, Renal Cell We also identified the lncRNA UBA6-AS1/miR5p/MMP9 regulatory axis for the progression of ccRCC. +genetics_overexpression_suppress 36523479 hsa-mir-4472 Breast Neoplasms miR-4472 levels were reduced, and repulsive guidance molecule A (RGMA) mRNA or protein levels were increased after overexpression of RP11-551L14.4 in the breast cancer cells. +circulation_biomarker_diagnosis_ns 36523365 hsa-mir-126 Myocardial Infarction, Acute CONCLUSION: Reduction of EV-associated miR-126 levels in the coronary blood of patients with AMI may be involved in acute coronary thrombosis events. +other 36523292 hsa-mir-1 Glioma The present study was to analyze the mechanism of microRNA (miR)-1 in regulating the proliferation and invasion of glioma cells. +genetics_overexpression_promote 36523183 hsa-mir-362 Osteoarthritis Additionally, overexpressed miR +genetics_knock down_promote 36523170 hsa-mir-760 Lung Neoplasms RAB3D was a target of miR-760, and its knockdown reversed the promotion effect of miR-760 inhibitor on the progression of curcumin-treated LC cells. +transcription factor target 36523152 hsa-mir-182 Reperfusion Injury, Cerebral Ischemia CONCLUSION: CXCR7 protects against cerebral I/R injury, possibly via the miR-182/TCF7L2/Hippo pathway. +circulation_biomarker_diagnosis_ns 36523143 hsa-mir-197 Atherosclerosis 3p was decreased in the serum of AS patients compared to healthy donors. +circulation_biomarker_diagnosis_up 36522766 hsa-mir-149 Carcinoma, Non-Small-Cell Lung CONCLUSION: Serum miRNAs miR-3149 and miR-4769.3p were up-regulated in NSCLC and may be potential biomarkers for early diagnosis of lung cancer. +circulation_biomarker_diagnosis_up 36522766 hsa-mir-4769 Carcinoma, Non-Small-Cell Lung CONCLUSION: Serum miRNAs miR-3149 and miR-4769.3p were up-regulated in NSCLC and may be potential biomarkers for early diagnosis of lung cancer. +exosome 36522730 hsa-mir-21 Colonic Neoplasms CONCLUSIONS: Our results implicated a reciprocal communication between colon cancer cells and Schwan cells that promoted the proliferation and metastasis of colon cancer, and identified NGF and exosomal miR +other 36522710 hsa-mir-126 Pulmonary Disease, Chronic Obstructive Decreased miR126 expression with reciprocal increase in ADAM9 may regulate endothelial cell survival and vascular remodeling in small pulmonary arteries and lung microvasculature in COPD and COPD-PH. +other 36522710 hsa-mir-126 Hypertension, Pulmonary Since CS decreases miR126 in microvascular lung endothelial cells, we set out to characterize the remodeling by pulmonary vascular size in COPD-PH and its relationship with miR126 in COPD and COPD-PH lungs. Decreased miR126 expression with reciprocal increase in ADAM9 may regulate endothelial cell survival and vascular remodeling in small pulmonary arteries and lung microvasculature in COPD and COPD-PH. +lncRNA target 36522683 hsa-mir-449b Esophageal Squamous Cell Carcinoma CONCLUSIONS: IGF2BP2 mediated circRUNX1 functions as an oncogenic factor to facilitate ESCC progression through the miR-449b-5p/FOXP3 axis, implying that circRUNX1 has the potential to be a promising diagnostic marker and therapeutic target for ESCC patients. +lncRNA target 36522638 hsa-mir-26a Parvoviridae Infections parvum as well as treated with miR-26a-mimic, miR-30a-mimic, miR-26a-mimic or miR-30a-inhibitor post C. +genetics_overexpression_suppress 36522613 hsa-mir-495 Melanoma 3p, and CREB1 overexpression enhanced melanoma cell viability by inhibiting miR +genetics_overexpression_promote 36522479 hsa-mir-181b Breast Neoplasms Overexpression of miR-181b-5p downregulated p53/p21 levels and inhibited doxorubicin-induced G1 arrest and senescence by suppressing BCLAF1 expression in vitro. +lncRNA target 36522211 hsa-mir-18b Pulpitis DUXAP8 upregulation and miR-18b-5p downregulation were found in pulpitis. CONCLUSIONS: Results demonstrated that LPS-induced cell injury in pulpitis was promoted by DUXAP8 through mediating miR-18b-5p/HIF3A axis. +exosome 36521318 hsa-mir-543 adhesions of uterus Furthermore, UCMSCs-derived exosomal miR-543 attenuated IUA-induced endometrial fibrosis in vivo, as shown by the decreased N-cadherin, alpha-SMA and fibronectin 1 protein expressions. +exosome 36521318 hsa-mir-543 Uterine Diseases Furthermore, UCMSCs-derived exosomal miR-543 attenuated IUA-induced endometrial fibrosis in vivo, as shown by the decreased N-cadherin, alpha-SMA and fibronectin 1 protein expressions. DISCUSSION: Collectively, UCMSCs-derived exosomal miR-543 was able to prevent endometrial fibrosis both in vitro and in vivo via downregulating N-cadherin. +genetics_knock down_suppress 36520963 hsa-mir-1 Nasopharyngeal Carcinoma Knockdown of lncRNA SNHG16 attenuates radioresistance of nasopharyngeal carcinoma cells by miR +exosome 36520505 hsa-mir-143 Periodontitis In conclusion, these results demonstrate that inflammatory PDLSCs facilitate M1 macrophage polarization through the exosomal miR +target gene 36520299 hsa-mir-2053 Colitis, Ulcerative Collectively, rs6214 increased UC susceptibility and suppresses IGF-1 expression by enhancing miR-2053 binding. +lncRNA target 36520091 hsa-mir-335 Bone Diseases In conclusion, melatonin facilitates osteogenesis in bone defect healing by enhancing miR5p expression and inhibiting the TNFalpha/NF-kappaB pathway. +circRNA target 36519785 hsa-mir-363 Prostatic Neoplasms We show that circEZH2(E2/E3) functions as a dual inhibitor for both miR363 and miR708 that target the EZH2 3'UTR and CDS, respectively, resulting in the upregulation of EZH2 expression and hence the downregulation of EZH2-repressed genes (e.g., CDH1 and DAB2IP), and enhancement of PCa cell proliferation, migration, invasion, and xenograft PCa growth. These findings show a novel autoenhancing EZH2-circEZH2(E2/E3) -miR363/miR708-EZH2 regulatory loop, by which circEZH2(E2/E3) plays important roles in PCa tumorigenesis and progression by upregulating EZH2, and may have potential diagnostic, prognostic, and therapeutic uses in PCa management. +circRNA target 36519785 hsa-mir-708 Prostatic Neoplasms We show that circEZH2(E2/E3) functions as a dual inhibitor for both miR363 and miR708 that target the EZH2 3'UTR and CDS, respectively, resulting in the upregulation of EZH2 expression and hence the downregulation of EZH2-repressed genes (e.g., CDH1 and DAB2IP), and enhancement of PCa cell proliferation, migration, invasion, and xenograft PCa growth. These findings show a novel autoenhancing EZH2-circEZH2(E2/E3) -miR363/miR708-EZH2 regulatory loop, by which circEZH2(E2/E3) plays important roles in PCa tumorigenesis and progression by upregulating EZH2, and may have potential diagnostic, prognostic, and therapeutic uses in PCa management. +lncRNA target 36519522 hsa-mir-874 Colorectal Neoplasms CONCLUSION: Circ-CCS expedited CRC through miR +circulation_biomarker_diagnosis_up 36519433 hsa-mir-155 Pre-Eclampsia RESULTS: About one-third of preeclamptic patients had high pl-miR-155 expression, which was positively correlated with circulating miR-155 levels. +genetics_knock down_promote 36519409 hsa-mir-124 Gastric Cancer 3p or increasing ZNF655 could counteract the effects of LINC01210 knockdown on GC cell development. +other 36519254 hsa-mir-519a Carcinoma, Hepatocellular CONCLUSION: These data provide the first evidence of clinical significance and function of circTMEM181, and suggest the circTMEM181/miR-519a-5p/ARHGAP29 axis in HCC development. +circulation_biomarker_diagnosis_ns 36519116 hsa-mir-93 Tuberculosis RESULTS: According to the stability ranking analyzed with the 5 computational programs, the top 4 candidates-miR-93, RNU44, miR-16, and glyceraldehyde 3-phosphate dehydrogenase-were used to normalize the transcript levels of 2 mycobacterial sRNAs, MTS2823 and MTS1338, which were observed to have higher copy numbers in the plasma of patients with TB. +circulation_biomarker_diagnosis_ns 36519116 hsa-mir-16 Tuberculosis RESULTS: According to the stability ranking analyzed with the 5 computational programs, the top 4 candidates-miR-93, RNU44, miR-16, and glyceraldehyde 3-phosphate dehydrogenase-were used to normalize the transcript levels of 2 mycobacterial sRNAs, MTS2823 and MTS1338, which were observed to have higher copy numbers in the plasma of patients with TB. +genetics_GWAS 36518850 hsa-mir-122 Carcinoma, Hepatocellular The aim of this study was to evaluate phenotypic and genetic heterogeneity of circulating epithelial cells (CECs) based on asialoglycoprotein receptor 1 (ASGR1) and miR +genetics_knock down_promote 36518817 hsa-mir-101 Pulmonary Disease, Chronic Obstructive 3p Suppresses mTOR and Causes Mitochondrial Fragmentation and Cell BACKGROUND: Cigarette smoke is assumed to cause the loss of airway wall structure in chronic obstructive pulmonary disease (COPD) by reducing airway smooth muscle cell (ASMC) function. +circulation_biomarker_diagnosis_ns 36518749 hsa-mir-138 Scleroderma, Systemic Accordingly, the gene expression of miR-138 was assessed to find any alterations in the whole blood of the SSc patients. +lncRNA target 36518289 hsa-mir-491 Colorectal Neoplasms 3p expression promotes CRC progression through regulating uMtCK. +circulation_biomarker_diagnosis_ns 36517751 hsa-mir-184 Cardiotoxicity We also found that distribution of particular miRNAs between of plasma and EVs (proportion between compartments) e.g., miR-184 in ALL, is altered, suggesting changes within secretory and miRNA sorting mechanisms. +circulation_biomarker_diagnosis_ns 36517751 hsa-mir-144 Cardiotoxicity Moreover, vesicular miR3p correlates with the highest number of echocardiographic parameters and is differentially expressed in the circulation of patients with dilated cardiomyopathy. +genetics_knock down_promote 36517015 hsa-mir-423 Cardiomegaly 5p knockdown exerts its protective effects on Ang II-induced cardiomyocyte hypertrophy in HCMs via modulating SUPT6H expression. +lncRNA target 36515797 hsa-mir-671 late onset Parkinson's disease UCA1 inhibition reduced MPP(+)-induced neuronal damage through the miR5p/KPNA4 pathway in SK-N-SH cells, providing a novel mechanism to understand the pathogenesis of PD. +genetics_knock down_suppress 36515797 hsa-mir-671 Inflammation KPNA4 overexpression offset the inhibitory influence of miR +lncRNA target 36515797 hsa-mir-671 Aicardi-Goutieres syndrome 5 UCA1 inhibition reduced MPP(+)-induced neuronal damage through the miR5p/KPNA4 pathway in SK-N-SH cells, providing a novel mechanism to understand the pathogenesis of PD. +exosome 36515680 hsa-mir-195a Acute Kidney Injury Furthermore, in vitro inhibition of miR-195a-5p alleviated the effect of Exos(AKI) induced mitochondrial dysfunction and cell injury. +other 36515567 hsa-mir-382 Squamous Cell Carcinoma of Head and Neck Our data demonstrate that circ_0000052 is oncogenic, and the circ_0000052/miR3p/PD-L1 axis is critical in HNSCC progression. +genetics_overexpression_suppress 36515277 hsa-mir-1290 Stomach Neoplasms MiR-1290 was predicted as a target of circ_0026344 and miR-1290 overexpression attenuated the anti-tumor effect of circ_0026344 on GC cells. CONCLUSION: In conclusion, circ_0026344 inhibited GC cell proliferation via the miR-1290/FBP2 axis, which might provide a new therapeutic target for GC patients. +exosome 36514348 hsa-mir-222 Pre-Eclampsia This study characterizes exosomes and determines exosomal miR-155 and miR-222 expression levels in women with gestational hypertension (GH) and preeclampsia (PE). The difference in the exosomal miR-155 and miR-222 expression in PE and GH suggested that these two disorders have different pathological pathways. +exosome 36514348 hsa-mir-222 Hypertension, Pregnancy-Induced This study characterizes exosomes and determines exosomal miR-155 and miR-222 expression levels in women with gestational hypertension (GH) and preeclampsia (PE). The difference in the exosomal miR-155 and miR-222 expression in PE and GH suggested that these two disorders have different pathological pathways. +exosome 36514348 hsa-mir-155 Pre-Eclampsia This study characterizes exosomes and determines exosomal miR-155 and miR-222 expression levels in women with gestational hypertension (GH) and preeclampsia (PE). +exosome 36514348 hsa-mir-155 Hypertension, Pregnancy-Induced This study characterizes exosomes and determines exosomal miR-155 and miR-222 expression levels in women with gestational hypertension (GH) and preeclampsia (PE). +other 36514216 hsa-mir-486 Pulmonary Disease, Chronic Obstructive 5p sponge to regulate CEMIP and promote hypoxic PASMC proliferation in pulmonary vascular remodelling in COPD. +genetics_overexpression_promote 36514078 hsa-mir-709 Spinal Cord Injuries Moreover, experiments confirmed that Treg cells targeted the NKAP via exosomal miR-709 to reduce microglia pyroptosis and promote motor function recovery after SCI. More importantly, The miR-709 overexpressed exosomes we constructed significantly reduced the inflammatory response and improved motor recovery after spinal cord injury. +other 36513954 hsa-mir-214 Breast Neoplasms 5p/ROCK1 pathway, which might provide a new perspective to investigate the development process of BC. +target gene 36513872 hsa-mir-196a Stomach Neoplasms miR-196a-5p Correlates with Chronic Atrophic Gastritis Progression to Gastric Cancer and Induces Malignant Biological Behaviors of Gastric Cancer Cells by Targeting ACER2. +genetics_overexpression_promote 36513585 hsa-mir-95 Triple Negative Breast Neoplasms CONCLUSION: Overexpression of circ_0001777 decreased proliferation, migration, and invasion of TNBC cells by regulating the miR +circulation_biomarker_diagnosis_ns 36513264 hsa-mir-21 renal fibrosis RESULTS: A positive correlation was found between plasma miR-21 levels and RF scores of rats after UUO surgery at Days 3, 7, 14 and 21. +other 36513253 hsa-mir-144 Non-alcoholic Fatty Liver Disease 5p was reduced in HFD-managed models and patients with NAFLD. +transcription factor target 36513242 hsa-mir-429 Kidney Diseases These findings suggest that endosulfan can lead to kidney cell injury by modulating ACE2 through up-regulating miR-429, providing new evidence for the pathogenesis of CKDu. +genetics_overexpression_suppress 36512648 hsa-mir-655 Thyroid Cancer, Papillary Overexpression of miR +lncRNA target 36512502 hsa-mir-122 Hepatitis C Our study identifies PLK1-ELAVL1/HuR-miR-122 signaling as a regulatory axis that is critical for HCV proliferation, and suggests that a therapeutic approach targeting this host cell signaling pathway could be useful for treating HCV and HCV-associated diseases. +lncRNA target 36512324 hsa-mir-532 Carcinoma, Ovarian Epithelial Furthermore, circATP2B4 induced macrophage M2 polarization by regulating the miR3p/SREBF1/PI3Kalpha/AKT axis, thereby leading to immunosuppression and ovarian cancer metastasis. +other 36511578 hsa-mir-155 Lung Neoplasms In the second group, miR5p allows to predict lung cancers and colon cancers. +other 36511578 hsa-mir-155 Colonic Neoplasms In the second group, miR5p allows to predict lung cancers and colon cancers. +other 36511422 hsa-mir-590 Myocardial Reperfusion Injury 3p regulates the TLR4/MyD88/NF-kappaB pathway by interacting with HMGB1 to protect against OGD/R-induced I/R injury. +other 36511396 hsa-mir-7 Alzheimer Disease This study provides new insights into the role of okanin in ischemic stroke and shows that the miR-7/NLRP3 axis plays an important role in mediating the beneficial effects of okanin on cerebral ischemia. +circulation_biomarker_diagnosis_up 36510992 hsa-mir-1246 Colorectal Neoplasms CONCLUSION: We confirmed the capability of circulating serum miR-1229 and miR-1246 as novel diagnostic biomarkers for CRC. +transcription factor target 36510830 hsa-mir-216b Angelman Syndrome The function of miR-216b-5p in AS remains unknown. miR-216b-5p alleviates the dysfunction of VSMCs and HUVECs caused by ox-LDL via repressing IGF2, and exerts protective functions to block the development of AS. +lncRNA target 36510610 hsa-mir-2116 Retinal Diseases CONCLUSION: Rg1 inhibits HG-induced proliferation, migration, angiogenesis, and VEGF expression in retinal endothelial cells through the lncRNA SNG7/miR5p/SIRT3 axis. +genetics_overexpression_promote 36510495 hsa-mir-1 Lupus Erythematosus, Systemic 5p was downregulated and negatively correlated with the overexpression of SLC15A4 in PBMCs of SLE patients. +lncRNA target 36510038 hsa-mir-29c Pancreatic Carcinoma RESULTS: Through differential analysis, five pancreatic cancer-related miRNAs (hsa-miR-29c, hsa-miR-107, hsa-miR +lncRNA target 36509232 hsa-mir-101 Osteosarcoma In addition, our study proved that TYMSOS promotes the malignancy of OS via elevating NETO2 expression as miR +other 36508822 hsa-mir-146b Immune System Diseases The results indicate that DEHP may interfere with the expression of miR-146b-5p, affect the composition of the lung microbiota, induce an imbalance in T cells, and lead to immune disorders and airway inflammation. +other 36508822 hsa-mir-146b Pneumonia The results indicate that DEHP may interfere with the expression of miR-146b-5p, affect the composition of the lung microbiota, induce an imbalance in T cells, and lead to immune disorders and airway inflammation. +genetics_knock down_suppress 36508789 hsa-mir-125a Pulmonary Fibrosis MiR-125a-5p anta-miR treatment contributes to the maintenance of Th1/Th2 balance during the progression of pulmonary fibrosis. Our findings indicated that knockdown miR-125a-5p could regulate T lymphocyte subsets and significantly reduce pulmonary fibrosis by targeting TRAF6. +lncRNA target 36508480 hsa-mir-199a High Grade Ovarian Neoplasms After treatment with CGA, cells derived from ovarian cancer cells were deregulated partially via the miR199a5p/DDR1 axis, significantly affecting tumour suppression. DDR1 has been identified as a direct target of miR199a5p in these ovarian cancer cells. +genetics_overexpression_promote 36508388 hsa-mir-1298 Uterine Cervical Neoplasms While silencing of ONECUT2 could suppress the proliferation of cervical cancer cells, its overexpression could nullify the tumor-suppressive effects of miR +lncRNA target 36508036 hsa-mir-370 Endometriosis CONCLUSION: IGF2-AS promotes endometriotic cell growth via regulating IGF2/miR3p axis and further activating PI3K/AKT/mTOR signaling pathway. +exosome 36506936 hsa-mir-425 Breast Neoplasms Transfection of exosomes is obtained from BC cells, and miR +circulation_biomarker_diagnosis_up 36506422 hsa-mir-200a Depressive Disorder, Major Relative serum levels of miR-30a, miR-30e, and miR-200a, normalized to U6, were measured by quantitative real-time PCR in MDD inpatients with (MDD/SI, N = 19) and without (MDD, N = 31) acute suicide risk. +lncRNA target 36506327 hsa-mir-17 Varicose Veins Furthermore, we found that lncRNA MIR17HG can regulate OSR1 by binding to hsa-miR5p and that PAX2 might treat VV by targeting OSR1. +lncRNA target 36506327 hsa-mir-21 Varicose Veins Furthermore, we found that lncRNA MIR17HG can regulate OSR1 by binding to hsa-miR5p and that PAX2 might treat VV by targeting OSR1. +transcription factor target 36506063 hsa-mir-26b Diabetes Mellitus, Type 1 Hsa-miR-26b-5p and hsa-miR5p were highlighted in our results, possibly acting on nuclear and mitochondrial dysfunction and, subsequently, T1DM dysregulation. +transcription factor target 36506063 hsa-mir-21 Diabetes Mellitus, Type 1 Hsa-miR-26b-5p and hsa-miR5p were highlighted in our results, possibly acting on nuclear and mitochondrial dysfunction and, subsequently, T1DM dysregulation. +transcription factor target 36506055 hsa-mir-92b Alstrom Syndrome Similarly, 1 miRNA (miR-92b-3p) was dysregulated in the opposite directions in ALMS and BBS patients, but diverged from 2 other groups. +transcription factor target 36506055 hsa-mir-92b Bardet-Biedl Syndrome 11 Similarly, 1 miRNA (miR-92b-3p) was dysregulated in the opposite directions in ALMS and BBS patients, but diverged from 2 other groups. +circulation_biomarker_diagnosis_up 36505330 hsa-mir-355 Mucocutaneous Lymph Node Syndrome CONCLUSION: Expression levels of miR-355 and miR-2911 were significantly up-regulated in peripheral blood of children with Kawasaki disease. +circulation_biomarker_diagnosis_up 36505330 hsa-mir-2911 Mucocutaneous Lymph Node Syndrome CONCLUSION: Expression levels of miR-355 and miR-2911 were significantly up-regulated in peripheral blood of children with Kawasaki disease. +circulation_biomarker_prognosis_ns 36505313 hsa-mir-127 Sepsis The areas under the ROC curve (AUC) of serum miR-127, SOFA score, and APACHE II score for predicting prognosis of sepsis patients were 0.748 (0.674-0.823), 0.810 (0.742-0.878) and 0.864 (0.811-0.916), respectively. +target gene 36505312 hsa-mir-370 Lung Neoplasms miR-370 impacts the biological behavior of lung cancer cells by targeting the SMAD1 signaling pathway. +genetics_knock down_promote 36505286 hsa-mir-216b Colorectal Neoplasms miR-216b overexpression suppressed tumor growth, metastasis and expressions of CPEB4, CD206 and IL-10 in CRC xenograft models. +lncRNA target 36505084 hsa-mir-31 Leukemia HFD-EX EVs had lower microRNA-193 and microRNA5p content, microRNAs implicated in inhibiting osteogenesis and leukemic cell expansion respectively, compared to HFD-SED EVs. +lncRNA target 36505084 hsa-mir-193 Leukemia HFD-EX EVs had lower microRNA-193 and microRNA5p content, microRNAs implicated in inhibiting osteogenesis and leukemic cell expansion respectively, compared to HFD-SED EVs. +circulation_biomarker_diagnosis_up 36504565 hsa-mir-18a Stomach Neoplasms CONCLUSION: A panel of circulating miR18a/21/125b could be suggested as a potential biomarker for the early detection of GC. +lncRNA target 36504472 hsa-mir-146a Diabetes Mellitus Furthermore, the downregulation of mir146a, as an inflammatory microRNA interacting with TLR4, showed another pathway, through which tropisetron improved diabetes-induced testicular injuries. +lncRNA target 36504384 hsa-mir-371a Necrosis BACKGROUND: Before postchemotherapy retroperitoneal lymph node dissection (pcRPLND), in patients with metastasized germ cell tumors (GCTs), those harboring necrosis (NEC) cannot be distinguished from those who have teratoma (TER), resulting in relevant overtreatment, whereas microRNA-371a-3p may be predictive for viable GCT. +lncRNA target 36504384 hsa-mir-371a Teratoma BACKGROUND: Before postchemotherapy retroperitoneal lymph node dissection (pcRPLND), in patients with metastasized germ cell tumors (GCTs), those harboring necrosis (NEC) cannot be distinguished from those who have teratoma (TER), resulting in relevant overtreatment, whereas microRNA-371a-3p may be predictive for viable GCT. +exosome 36504133 hsa-mir-21 Hyperglycemia This study aimed to investigate the effects of AS-IV-mediated EPCs exosomal miR-21 (EPC-exos-miR-21) on high glucose (HG) damaged endothelial cells. +circulation_biomarker_diagnosis_up 36504065 hsa-mir-342 Arthritis, Rheumatoid 3p in peripheral blood mononuclear cells (PBMCs) of patients with rheumatoid arthritis (RA) and its effect on inflammatory response and migration of synovial fibroblasts in RA (RA-FLS). +genetics_knock down_suppress 36504056 hsa-mir-4772 Ovarian Neoplasms Survival analysis was carried out to identify the survival-related hub genes, and the results were validated using the data of 399 patients with ovarian cancer from GEO database and the sequencing results of SKOV3 cells transfected with miR-4772 mimics or inhibitor. +genetics_overexpression_promote 36504050 hsa-mir-607 Carcinoma, Hepatocellular Overexpression of miR-607 inhibits HCC growth and metastasis possibly by down- regulating TRPC5, which causes Akt signaling inactivation. +other 36503407 hsa-mir-520h Hypertension, Pregnancy-Induced Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia. +other 36503407 hsa-mir-374a Pregnancy Complications 5p with preterm birth and preeclampsia. +other 36503407 hsa-mir-520h Pregnancy Complications 5p with preterm birth and preeclampsia. +other 36503407 hsa-mir-374a Pre-Eclampsia Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia. +other 36503407 hsa-mir-520h Premature Birth Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia. +other 36503407 hsa-mir-374a Premature Birth Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia. +other 36503407 hsa-mir-191 Hypertension, Pregnancy-Induced Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia. +other 36503407 hsa-mir-374a Hypertension, Pregnancy-Induced Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia. +other 36503407 hsa-mir-191 Premature Birth Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia. +other 36503407 hsa-mir-520h Pre-Eclampsia Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia. +other 36503407 hsa-mir-628 Pregnancy Complications 5p. +other 36503407 hsa-mir-191 Pre-Eclampsia Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia. +other 36503407 hsa-mir-191 Pregnancy Complications 5p with preterm birth and preeclampsia. +other 36503407 hsa-mir-125b Pregnancy Complications 5p. +other 36503407 hsa-mir-518b Pregnancy Complications 5p with preterm birth and preeclampsia. +other 36503407 hsa-mir-518b Premature Birth Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia. +other 36503407 hsa-mir-518b Hypertension, Pregnancy-Induced Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia. +other 36503407 hsa-mir-518b Pre-Eclampsia Few miRNAs were associated with more than one pregnancy complication: miR-518b and miR-520h with preeclampsia and gestational hypertension, miR-374a-5p and miR5p with preterm birth and preeclampsia. +lncRNA target 36503346 hsa-mir-8082 Osteoarthritis In our study, patients with OA showed downregulation of NAV2-AS5, upregulation of miR-8082, and downregulation of TNFAIP3 interacting protein 2 (TNIP2). In conclusion, these findings indicate that NAV2-AS5 relieves chondrocyte inflammation by targeting miR-8082/TNIP2 in OA, which provides a new theoretical basis for OA therapy. +lncRNA target 36503162 hsa-mir-581 Prostatic Neoplasms In total, our findings revealed that circPHF16 suppressed prostate cancer metastasis through the circPHF16/miR-581/Wnt/beta-catenin pathways. +tissue_expression_up 36502883 hsa-mir-146a Triple Negative Breast Neoplasms The analysis of the external validation cohorts corroborated the unfavorable nature of miR-146a repression regarding patients' survival and, strikingly, unveiled the ability of miR-146a to predict TNBC metastasis. +target gene 36502446 hsa-mir-27b Lymphoma, Large B-Cell, Diffuse miR-27b can inhibit the proliferation and invasiveness of DLBCL cells and promote the apoptosis of the cells by targeting MET/PI3K/AKT pathway. +transcription factor target 36499744 hsa-mir-122 Fibrosis, Renal 5p inhibitor suppressed renal fibrosis and downregulated COL1A2 and FN1. +genetics_overexpression_suppress 36499676 hsa-mir-145 Carcinoma, Non-Small-Cell Lung 5p by BMI1 overexpression could lead to the enhanced expression of Sp1 to induce the EMT process in pemetrexed-resistant NSCLC cells. +other 36499626 hsa-mir-200c Ovarian Neoplasms Moreover, miR-200c increased the sensitivity of ovarian cancer cells to cisplatin treatment by regulating mortalin levels. The combination of cisplatin and miR-200c significantly enhanced the therapeutic effects on ovarian cancer in vivo, suggesting that miR-200c may serve as a potential therapeutic agent for ovarian cancer. +lncRNA target 36499626 hsa-mir-200b Ovarian Neoplasms In this study, microRNA (miR)-200b/c downregulated mortalin expression and inhibited the proliferation and migration of the paired cisplatin-sensitive (A2780S) and cisplatin-resistant (A2780CP) epithelial ovarian cancer cell lines. +other 36499586 hsa-mir-122 Colonic Neoplasms In conclusions, the study has explored the role of miR-122 in CRC and has identified a closely related group of genes influencing the prognosis of CRC in multiple ways. +other 36499552 hsa-mir-342 Heart Failure 3p) revealed pathways related to HF pathogenesis. +other 36499552 hsa-mir-125a Heart Failure 3p) revealed pathways related to HF pathogenesis. +other 36499552 hsa-let-7a Heart Failure 3p) revealed pathways related to HF pathogenesis. +transcription factor target 36499501 hsa-mir-186 Urinary Bladder Neoplasms 5p were confirmed as interfering with the stability of the mRNAs of DAP10, CD96, and the perforin gene in NK cells and may be potential targets used in the therapy for BC. +other 36499397 hsa-mir-200c FG syndrome miR-200c was upregulated in urine from patients with minimal change disease, membranous glomerulonephritis and focal segmental glomerulosclerosis and also in transforming growth factor beta (TGF-beta) stressed glomerular endothelial cells, but not in podocytes. +other 36499397 hsa-mir-200c Hematologic Diseases We investigated the expression of miR-200c in urine from patients with different renal diseases as a potential candidate involved in podocytopathies. +other 36499397 hsa-mir-200c Glomerulonephritis, Membranous miR-200c was upregulated in urine from patients with minimal change disease, membranous glomerulonephritis and focal segmental glomerulosclerosis and also in transforming growth factor beta (TGF-beta) stressed glomerular endothelial cells, but not in podocytes. +other 36499397 hsa-mir-200c Nephrosis, Lipoid miR-200c was upregulated in urine from patients with minimal change disease, membranous glomerulonephritis and focal segmental glomerulosclerosis and also in transforming growth factor beta (TGF-beta) stressed glomerular endothelial cells, but not in podocytes. +epigenetics 36499350 hsa-mir-124-2 Acquired Immunodeficiency Syndrome Our bisulfite-converted genomic DNA sequencing also revealed significant promoter DNA methylation in the pri-miR +genetics_overexpression_suppress 36499299 hsa-mir-4732 Premature Birth Small RNA sequencing (small RNA-seq) of five samples from women with a subsequent sPTD and their matched controls revealed significant down-regulation of miR-23b-5p and miR-125a-3p in sPTD cases compared to controls, whereas miR5p was significantly overexpressed. +other 36499299 hsa-mir-125a Premature Birth Statistical analysis demonstrated that miR-125a is a promising early predictor for sPTL (AUC: 0.895; 95% CI: 0.814-0.972; p < 0.001), independent of the confounding factors tested, providing a useful basis for the development of a novel non-invasive predictive test to assist clinicians in estimating patient-specific risk. +other 36499183 hsa-mir-18a Prostatic Neoplasms In conclusion, deregulation of the miR-18a-5p/P4HB network can contribute to the developmental origins of prostate cancer in maternally malnourished offspring, highlighting the need for improving maternal healthcare during critical windows of vulnerability early in life. +other 36499129 hsa-mir-21 Breast Neoplasms miR-21 is upregulated in breast cancer that has been linked to drug resistance and carcinogenic processes. +other 36499093 hsa-mir-26a Extramedullary Multiple Myeloma Further, miR-26a-5p and miR-30e-5p were found to be significantly down-regulated in EMD compared to MM. +other 36499048 hsa-mir-222 Frontotemporal Dementia 3p (FC: 2.1, p = 0.01, FDR = 0.893). +other 36499048 hsa-mir-140 Frontotemporal Dementia 3p (FC: 2.1, p = 0.01, FDR = 0.893). +other 36499048 hsa-mir-15a Frontotemporal Dementia 3p (FC: 2.1, p = 0.01, FDR = 0.893). +other 36499048 hsa-mir-124 Frontotemporal Dementia 3p (FC: 2.1, p = 0.01, FDR = 0.893). +other 36499048 hsa-mir-106b Frontotemporal Dementia 3p (FC: 2.1, p = 0.01, FDR = 0.893). +other 36499023 hsa-mir-369 Diabetes Mellitus, Type 2 3p). +other 36499023 hsa-mir-369 Hypoglycemia 3p). +genetics_overexpression_promote 36498905 hsa-mir-29c Pulmonary Fibrosis miR-29c-3p and miR-30a-5p are overexpressed in ASSD-ILD+ patients compared with ILD-. +genetics_overexpression_promote 36498905 hsa-mir-29c Antisynthetase syndrome miR-29c-3p and miR-30a-5p are overexpressed in ASSD-ILD+ patients compared with ILD-. +circRNA target 36497344 hsa-mir-934 Breast Neoplasms Altogether, these findings reveal that circRNF10 functions as a novel anti-oncogene in BC via sponging miR-934 and suppressing the PI3K/Akt/MICA pathway. +exosome 36497115 hsa-mir-20a Carcinoma, Hepatocellular In summary, LIMA1 is a tumour suppressor that inhibits the Wnt/beta-catenin signalling pathway and is downregulated by CAF-derived exosomes carrying oncogenic miR-20a-5p in HCC. +circulation_biomarker_diagnosis_ns 36497090 hsa-mir-342 Alzheimer Disease 5p was dysregulated in human circulating sEVs from AD patients; sEV transfer of miR +circulation_biomarker_diagnosis_ns 36497052 hsa-mir-125a Moyamoya Disease CircZXDC sponges miR-125a-3p to increase ABCC6 expression, which induces ERS (endoplasmic reticulum stress), and subsequently regulates VSMC transdifferentiation from the contractive phenotype to the synthetic phenotype, contributing to the intima thickness of MMD vessels. Our findings provide insight into the pathophysiological mechanisms of MMD and indicate that the circZXDC-miR-125a-3p-ABCC6 axis plays a pivotal role in the progression of MMD. +other 36497036 hsa-mir-1274a Prostatic Neoplasms An assessment of microarray data of prostate cancer and normal samples using the Limma package led to the identification of differential expressed (DE) RNAs that we stratified into mRNA, lncRNA, and miRNAs, resulting in 684 DEmRNAs, including 437 downregulated DEmRNAs (such as TGM4 and SCGB1A1) and 241 upregulated DEmRNAs (such as TDRD1 and CRISP3); 6 DElncRNAs, including 1 downregulated DElncRNA (H19) and 5 upregulated DElncRNAs (such as PCA3 and PCGEM1); and 59 DEmiRNAs, including 30 downregulated DEmiRNAs (such as hsa-miR-1274a and hsa-miR-1274b) and 29 upregulated DEmiRNAs (such as hsa-miR-1268 and hsa-miR5p). +other 36497036 hsa-mir-1207 Prostatic Neoplasms An assessment of microarray data of prostate cancer and normal samples using the Limma package led to the identification of differential expressed (DE) RNAs that we stratified into mRNA, lncRNA, and miRNAs, resulting in 684 DEmRNAs, including 437 downregulated DEmRNAs (such as TGM4 and SCGB1A1) and 241 upregulated DEmRNAs (such as TDRD1 and CRISP3); 6 DElncRNAs, including 1 downregulated DElncRNA (H19) and 5 upregulated DElncRNAs (such as PCA3 and PCGEM1); and 59 DEmiRNAs, including 30 downregulated DEmiRNAs (such as hsa-miR-1274a and hsa-miR-1274b) and 29 upregulated DEmiRNAs (such as hsa-miR-1268 and hsa-miR5p). +other 36497036 hsa-mir-1268 Prostatic Neoplasms An assessment of microarray data of prostate cancer and normal samples using the Limma package led to the identification of differential expressed (DE) RNAs that we stratified into mRNA, lncRNA, and miRNAs, resulting in 684 DEmRNAs, including 437 downregulated DEmRNAs (such as TGM4 and SCGB1A1) and 241 upregulated DEmRNAs (such as TDRD1 and CRISP3); 6 DElncRNAs, including 1 downregulated DElncRNA (H19) and 5 upregulated DElncRNAs (such as PCA3 and PCGEM1); and 59 DEmiRNAs, including 30 downregulated DEmiRNAs (such as hsa-miR-1274a and hsa-miR-1274b) and 29 upregulated DEmiRNAs (such as hsa-miR-1268 and hsa-miR5p). +other 36497036 hsa-mir-1274b Prostatic Neoplasms An assessment of microarray data of prostate cancer and normal samples using the Limma package led to the identification of differential expressed (DE) RNAs that we stratified into mRNA, lncRNA, and miRNAs, resulting in 684 DEmRNAs, including 437 downregulated DEmRNAs (such as TGM4 and SCGB1A1) and 241 upregulated DEmRNAs (such as TDRD1 and CRISP3); 6 DElncRNAs, including 1 downregulated DElncRNA (H19) and 5 upregulated DElncRNAs (such as PCA3 and PCGEM1); and 59 DEmiRNAs, including 30 downregulated DEmiRNAs (such as hsa-miR-1274a and hsa-miR-1274b) and 29 upregulated DEmiRNAs (such as hsa-miR-1268 and hsa-miR5p). +other 36496421 hsa-mir-195 Adenocarcinoma of Lung We also demonstrate that D-limonene-miRSREBP1/FASN axis is a potential preventive intervention for mediating the progression and development of LUAD induced by PM(2.5) exposure. +other 36496032 hsa-mir-342 Ischemic Stroke SIGNIFICANCE: This study suggests that PEG11as regulates neuronal apoptosis by miR5p/PFN1 axis, which may contribute to our understanding of pathogenesis and provide a potential therapeutic option for cerebral I/R. +genetics_knock down_promote 36495604 hsa-mir-652 Carcinoma, Hepatocellular 3p, and the knockdown of TNRC6A restored repressed EMT and HCC metastasis caused by the inhibition of miR +other 36495516 hsa-mir-29a Chronic Kidney Disease Then, Mir-29a-5p, sclerostin and fetuin-A are abnormally expressed in chronic kidney disease. +other 36495516 hsa-mir-29a Vascular Calcification Results showed that compared with the control group, the expression of mir-29a-5p and sclerostin in the study group was higher, and the expression of fetuin-A was lower, the difference was statistically significant (P < 0.05); The expression of mir-29a-5p, sclerostin and fetuin-A in calcified group was higher than that in non-calcified group, and the expression of fetuin-A was lower (P < 0.05); Mir-29a-5p and sclerostin showed positive correlation (r=6.776, P=0.011); The expression of mir-29a-5p and fetuin-A showed negative correlation (r=-5.326, P=0.001); The expression of mir-29a-5p and sclerostin showed negative correlation (r=-9.677, P=0.001); Mir-29a-5p and sclerostin were positively correlated with vascular calcification (r=0.695, P=0.001; r=0.715, P=0.001), and fetuin-A was positively correlated with vascular calcification (r = -0.953, P = 0.001). +lncRNA target 36495514 hsa-mir-144 Carcinoma, Hepatocellular The liver tissue of miR-144 is low, the level of gene expression CCNB1 protein expression level is higher, the expression level in liver cancer cells directly influences the curative effect of hepatocellular carcinoma patients, the miR-144 gene can negative regulation CCNB1 protein, through this kind of negative adjustment to the biological behavior of liver cancer cells have a profound impact. +lncRNA target 36495510 hsa-mir-382 Colorectal Neoplasms It is concluded that Circ_0022340 promoted colorectal cancer progression via recruiting HNRNPC to stabilize EBF1 mRNA and thereby activated SYT7 or miR5p/ELK1 axis, which might provide a novel target for CRC treatment. +transcription factor target 36495508 hsa-mir-29a Renal Insufficiency, Chronic Thus, miR-29a-5p/GSAP might be a potential target for the treatment of vascular calcification. +other 36495505 hsa-mir-1 Hypertension The results showed that the apoptosis rate of myocardial cells in the miRNA-1 group decreased (0.710 /- 0.009661)% vs (1.066667 /- 0.02603)% compared with that in the spontaneous hypertension control group (P < 0.001). +other 36495504 hsa-mir-29a Kidney Failure, Chronic Mir-129 and Mir-29a-5p showed high expression in the patients with end-stage renal disease, and they also increased with the occurrence of vascular calcification, and they showed a positive correlation in the vascular calcification of end-stage renal disease. +circulation_biomarker_diagnosis_up 36495497 hsa-mir-193a Aortic Aneurysm, Thoracic In the current study, we discovered that miR-193a-5p was expressed at low levels in the blood of TAA patients. +epigenetics 36495416 hsa-mir-217 Leukemia, Myelogenous, Chronic, BCR-ABL Positive DNMT3A could be the molecular target of miR-217 by regulating PER2 gene methylation and getting involved with the occurrence and development of CML. +other 36495003 hsa-mir-155 Periodontal Diseases CONCLUSIONS: These results suggest that salivary miR-146a, miR-146b, miR142-3p, miR-155, and miR-203 gene expressions increased with the progression of periodontal disease, but unchanged after periodontal treatment. +other 36495003 hsa-mir-203 Periodontal Diseases CONCLUSIONS: These results suggest that salivary miR-146a, miR-146b, miR142-3p, miR-155, and miR-203 gene expressions increased with the progression of periodontal disease, but unchanged after periodontal treatment. +other 36495003 hsa-mir-146a Periodontal Diseases CONCLUSIONS: These results suggest that salivary miR-146a, miR-146b, miR142-3p, miR-155, and miR-203 gene expressions increased with the progression of periodontal disease, but unchanged after periodontal treatment. +other 36495003 hsa-mir-142 Periodontal Diseases CONCLUSIONS: These results suggest that salivary miR-146a, miR-146b, miR142-3p, miR-155, and miR-203 gene expressions increased with the progression of periodontal disease, but unchanged after periodontal treatment. +other 36495003 hsa-mir-146b Periodontal Diseases CONCLUSIONS: These results suggest that salivary miR-146a, miR-146b, miR142-3p, miR-155, and miR-203 gene expressions increased with the progression of periodontal disease, but unchanged after periodontal treatment. +target gene 36494581 hsa-mir-219 Ovarian Neoplasms miR-219-5p attenuates cisplatin resistance of ovarian cancer by inactivating Wnt/β-catenin signaling and autophagy via targeting HMGA2. +lncRNA target 36494481 hsa-mir-34a Carcinoma, Hepatocellular Mechanistic studies suggest that ALDOA is a direct target of miR-34a-5p, which can inhibit glycolysis in hepatocellular carcinoma cells by targeting the 3'UTR of ALDOA. +other 36494341 hsa-mir-199a Carcinoma, Renal Cell Mechanistically, circPLIN2 not only increased the stability of the c-Myc and MARCKSL1 mRNAs by binding to the KH domains of IGF2BP proteins but also competitively sponged miR-199a-3p to abolish the repressive effect of miR-199a-3p on ZEB1 expression, which ultimately resulted in ccRCC tumorigenesis and progression. +exosome 36494333 hsa-mir-197 Adenocarcinoma of Lung In conclusion, LUAD cells-derived exosomal miR +other 36494326 hsa-mir-21 Crohn Disease In conclusion, the level of miR-21 decreased in CD, resulting in an upregulated PI3K-Akt-mTOR signaling pathway, compromised immune tolerance, and elevated inflammation. +exosome 36494212 hsa-mir-17 Virus Diseases EVs participated in TLR3-dependent antiviral immunity, protecting the host from viral infections through both EV-mediated functional delivery of miR-17 and direct virion neutralization after binding to virus ligands via surface receptors, including LDLR and ICAM-1. +exosome 36493861 hsa-mir-146a Peripheral Nerve Injuries CONCLUSION: Our study confirmed that miR-146a-5p was significantly decreased in SC-Exos under the ischemia-hypoxic microenvironment of the injury site after PNI, which mediated its shift from promoting macrophage M2 polarization (anti-inflammation) to promoting M1 polarization (pro-inflammation), thereby limiting axonal regeneration and functional recovery. +genetics_knock down_promote 36493845 hsa-mir-493 Esophageal Squamous Cell Carcinoma Moreover, our multiple gain-and loss-of-functional experiments proved that a combination of miR +genetics_overexpression_promote 36484970 hsa-mir-19b Glioma The glioma patients exhibited overexpressed miR-19b-3p and poorly-expressed SOCS3. +lncRNA target 36484486 hsa-mir-515 Stomach Neoplasms CircPDSS1 conferred DDP resistance through the miR +circulation_biomarker_diagnosis_down 36484399 hsa-mir-340 Duane Retraction Syndrome In the blood of DR patients and the DR model, lncRNA SNHG1 was increased and miR +genetics_knock down_promote 36484173 hsa-mir-873 Esophageal Squamous Cell Carcinoma CONCLUSION: CircLPAR3 knockdown suppressed ESCC cell growth, metastasis, and Warburg effect by miR +target gene 36484007 hsa-mir-29c Stomach Neoplasms miR-29c inhibits metastasis of gastric cancer cells by targeting VEGFA. +other 36483920 hsa-mir-23b Hypertension, Pulmonary 5p, and hsa-mir-23b-3p were associated with HPH. +other 36483920 hsa-mir-155 Hypertension, Pulmonary 5p, and hsa-mir-23b-3p were associated with HPH. +other 36483920 hsa-mir-146a Hypertension, Pulmonary 5p, and hsa-mir-23b-3p were associated with HPH. +other 36483920 hsa-mir-124 Hypertension, Pulmonary 5p, and hsa-mir-23b-3p were associated with HPH. +other 36483920 hsa-mir-195 Hypertension, Pulmonary 5p, and hsa-mir-23b-3p were associated with HPH. +other 36483920 hsa-mir-24 Hypertension, Pulmonary 5p, and hsa-mir-23b-3p were associated with HPH. +exosome 36483681 hsa-mir-134 Squamous Cell Carcinoma of Head and Neck We previously reported that miR-134 blocks the expression of its targeting protein LAMC2 via the PI3K/AKT pathway and inhibits cancer stem cell (CSC) migration and invasion in oral squamous cell carcinoma (OSCC). This study hypothesize that OSCC-CSC-derived small extracellular vesicles (OSCC-CSC-sEVs) transfer a ceRNA of miR-134 and consequently promote M2 macrophage polarization by targeting LAMC2 via the PI3K/AKT pathway through in vitro and in vivo experiment methods. +other 36482859 hsa-mir-125 Cardiovascular Diseases More specifically, compared to healthy controls and CVD, subjects with periodontitis and periodontitis CVD showed higher GCF miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 200b-3p, and miRNA 200b-5p (p < .05) and lower miRNA 100-5p, miRNA 125-5p levels (p < .05). +other 36482859 hsa-mir-21 Cardiovascular Diseases More specifically, compared to healthy controls and CVD, subjects with periodontitis and periodontitis CVD showed higher GCF miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 200b-3p, and miRNA 200b-5p (p < .05) and lower miRNA 100-5p, miRNA 125-5p levels (p < .05). +other 36482859 hsa-mir-200b Cardiovascular Diseases More specifically, compared to healthy controls and CVD, subjects with periodontitis and periodontitis CVD showed higher GCF miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 200b-3p, and miRNA 200b-5p (p < .05) and lower miRNA 100-5p, miRNA 125-5p levels (p < .05). +other 36482859 hsa-mir-21 Periodontitis More specifically, compared to healthy controls and CVD, subjects with periodontitis and periodontitis CVD showed higher GCF miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 200b-3p, and miRNA 200b-5p (p < .05) and lower miRNA 100-5p, miRNA 125-5p levels (p < .05). Furthermore, the multivariate regression analysis evidenced that periodontitis (miRNA 21-3p, 100-5p) and periodontal inflamed surface area (PISA) (miRNA 7a-5p, 21-3p, 21-5p, 100-5p, 125-5p, 200b-3p) were significant predictors of GCF miRNAs concentration (p < .05). +other 36482859 hsa-mir-7a Periodontitis More specifically, compared to healthy controls and CVD, subjects with periodontitis and periodontitis CVD showed higher GCF miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 200b-3p, and miRNA 200b-5p (p < .05) and lower miRNA 100-5p, miRNA 125-5p levels (p < .05). Furthermore, the multivariate regression analysis evidenced that periodontitis (miRNA 21-3p, 100-5p) and periodontal inflamed surface area (PISA) (miRNA 7a-5p, 21-3p, 21-5p, 100-5p, 125-5p, 200b-3p) were significant predictors of GCF miRNAs concentration (p < .05). +other 36482859 hsa-mir-7a Cardiovascular Diseases More specifically, compared to healthy controls and CVD, subjects with periodontitis and periodontitis CVD showed higher GCF miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 200b-3p, and miRNA 200b-5p (p < .05) and lower miRNA 100-5p, miRNA 125-5p levels (p < .05). +other 36482859 hsa-mir-100 Cardiovascular Diseases More specifically, compared to healthy controls and CVD, subjects with periodontitis and periodontitis CVD showed higher GCF miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 200b-3p, and miRNA 200b-5p (p < .05) and lower miRNA 100-5p, miRNA 125-5p levels (p < .05). +lncRNA target 36482855 hsa-mir-372 Epilepsy CONCLUSION: Our study suggests that targeting HOXA-AS2 could alleviate cellular damages in the epileptic model by regulating miR3p/STAT3 axis. +other 36482742 hsa-mir-1290 Carcinoma, Non-Small-Cell Lung In summary, circSCN8A represses cell proliferation and metastasis in NSCLC by regulating the miR-1290/ACSL4 axis to induce ferroptosis. +circulation_biomarker_diagnosis_up 36482739 hsa-mir-455 Colorectal Neoplasms 3p expression was both higher in the serum and tumor tissues of CRC patients. +other 36482542 hsa-mir-140 Squamous Intraepithelial Lesions of the Cervix CONCLUSIONS: The differential expression and potential effects of the lncRNA BACH1-IT1/miR5p/VEGFA axis, key genes, VEGFA and FOS, and MAPK signaling in CIN were clarified, and the occurrence and potential effects of CIN were further clarified. +lncRNA target 36482494 hsa-mir-142 Ovarian Neoplasms Overall, our data demonstrate that hsa_circ_0000119 facilitated ovarian cancer development through increasing CDH13 expression via promoting DNMT1 expression by sponging miR +genetics_knock down_promote 36482354 hsa-mir-503 Pancreatic Carcinoma 5p down-regulation and ANLN up-regulation reversed the effects of LINC00460 knockdown on inhibiting the proliferation, migration and invasion, and on promoting the apoptosis, G0/G1 phase arrest, and the sensitivity of PC cells to the cytotoxicity of CD8(+) T cells. +transcription factor target 36482325 hsa-mir-431 Carcinoma, Hepatocellular Expression of HHIP, a possible miR5p target gene, was significantly downregulated in HCC cells. +circulation_biomarker_diagnosis_ns 36482069 hsa-mir-34a Hepatitis B, Chronic Furthermore, clinical investigation showed that CCAT2 and Smad4 expression level were significantly induced, while miR-34a-5p was significantly decreased in HBV related liver fibrosis serum. +circulation_biomarker_diagnosis_ns 36482069 hsa-mir-34a Fibrosis miR-34a-5p inhibitor undo protective regulation of sh-CCAT2 in liver fibrosis. Furthermore, clinical investigation showed that CCAT2 and Smad4 expression level were significantly induced, while miR-34a-5p was significantly decreased in HBV related liver fibrosis serum. +genetics_overexpression_promote 36481751 hsa-mir-185 Hyperlipidemias 3p overexpression or MAML1 silencing reduced levels of serum lipids, mitigated oxidative stress and inflammatory response, relieved lipid accumulation and pathological morphology in liver tissues in hyperlipidemia rats; while up-regulated MAML1 reversed the effects of augmented miR +transcription factor target 36481664 hsa-mir-29a COVID-19 Intriguingly, hsa-miR-29a-3p significantly downregulated in severe COVID-19 was predicted to bind the 3'-untranslated regions of both IL17RA and THBS1 mRNAs. These findings strongly suggest that dysregulated expression of THBS1, IL17RA, and hsa-miR-29a-3p involves severe COVID-19. +genetics_knock down_promote 36481629 hsa-mir-1 Ovarian Neoplasms 3p mimics on enhancing the sensitivity of human ovarian cancer cells to Erastin-induced or RSL3-induced ferroptosis was abrogated by overexpression of FZD7(P<0.05 or P<0.01). +other 36481589 hsa-mir-27a Infertility, Female In summary, our findings reveal that miR-27a-3p is a novel regulator of E2 synthesis and may predict litter size of Hu sheep, providing insight into mechanisms underlying granulosa cell function and female fertility. +lncRNA target 36481473 hsa-mir-936 Ovarian Neoplasms These data suggested that circ_0021573 might promote the malignant phenotypes of ovarian cancer cells by functioning as a ceRNA for miR-936 to induce CUL4B, which provided a promising target for the prevention and inhibition of ovarian cancer. +exosome 36481205 hsa-mir-27a Arthritis, Rheumatoid Summarily, exosomal lncRNA TRAFD1-4:1 derived from RA-FLSs suppressed chondrocyte proliferation and migration through degrading CECM by upregulating CXCL1 as a sponge of miR-27a-3p. +other 36480308 hsa-mir-21 Prostatic Neoplasms Herein, a solution-gated graphene transistor (SGGT) biosensor for the ultrasensitive and rapid quantification detection of the early prostate cancer-relevant biomarker, miRNA-21 is reported. +genetics_overexpression_promote 36479734 hsa-mir-199b Carcinoma, Hepatocellular Moreover, miR-199b-5p could target OTX1, and OTX1 overexpression reverted the repressive impact of miR-199b-5p mimic on the malignancy of HCC cells. In conclusion circKIAA1429 might promote HCC progression via regulating miR-199b-5p/OTX1 axis. +lncRNA target 36479657 hsa-mir-646 Pancreatic Carcinoma Delivery of circ_0086375 by nanoparticles suppresses the tumorigenicity of pancreatic cancer by miR-646/SLC4A4 axis, suggesting a new potential target for future pancreatic cancer treatment. +lncRNA target 36479622 hsa-mir-101 Glioma Therefore, targeting SPRY4-IT1/miR +circulation_biomarker_prognosis_up 36478451 hsa-mir-15b Prostatic Neoplasms In the training and validation cohort, miR-15b-5p and miR-106b-5p were confirmed to be significantly upregulated in tissue of aggressive PCa when their level was associated with disease aggressiveness. Furthermore, we established a prognostic score combining the level of miR-15b-5p and miR-106b-5p with serum PSA level, which discriminated indolent PCa from an aggressive form with even higher analytical parameters (AUC being 0.9338 in the training set and 0.8014 in the validation set, respectively). +circulation_biomarker_prognosis_up 36478451 hsa-mir-106b Prostatic Neoplasms In the training and validation cohort, miR-15b-5p and miR-106b-5p were confirmed to be significantly upregulated in tissue of aggressive PCa when their level was associated with disease aggressiveness. Furthermore, we established a prognostic score combining the level of miR-15b-5p and miR-106b-5p with serum PSA level, which discriminated indolent PCa from an aggressive form with even higher analytical parameters (AUC being 0.9338 in the training set and 0.8014 in the validation set, respectively). +other 36478437 hsa-mir-23a Infertility, Female Overall, our findings suggest that the SNVs g.-283G>C and g.-271C>T in the miR-23a promoter are causal variants affecting GC apoptosis and miR-23a may be a potential small-molecule nonhormonal drug for regulating female fertility. +lncRNA target 36478207 hsa-mir-494 Pneumonia, Mycoplasma CONCLUSION: Overall, by suppressing HTR8/SVneo cell growth and migration via the miR3p/PTEN axis and other mechanisms, LINC00534 offers new insight into PE pathogenesis. +other 36477577 hsa-mir-186 Diabetes Mellitus RESULTS: We identified five miRs (miR-144, miR-186, miR-203a, miR-205, miR-206) that constituted the optimal predictors of incident T2D after adjustment for covariates (hazards ratio 2.81 (95% confidence interval (CI) 2.05, 3.87); p < 0.001). +other 36477577 hsa-mir-144 Diabetes Mellitus RESULTS: We identified five miRs (miR-144, miR-186, miR-203a, miR-205, miR-206) that constituted the optimal predictors of incident T2D after adjustment for covariates (hazards ratio 2.81 (95% confidence interval (CI) 2.05, 3.87); p < 0.001). +other 36477577 hsa-mir-206 Diabetes Mellitus RESULTS: We identified five miRs (miR-144, miR-186, miR-203a, miR-205, miR-206) that constituted the optimal predictors of incident T2D after adjustment for covariates (hazards ratio 2.81 (95% confidence interval (CI) 2.05, 3.87); p < 0.001). +other 36477577 hsa-mir-203a Diabetes Mellitus RESULTS: We identified five miRs (miR-144, miR-186, miR-203a, miR-205, miR-206) that constituted the optimal predictors of incident T2D after adjustment for covariates (hazards ratio 2.81 (95% confidence interval (CI) 2.05, 3.87); p < 0.001). +other 36477577 hsa-mir-205 Diabetes Mellitus RESULTS: We identified five miRs (miR-144, miR-186, miR-203a, miR-205, miR-206) that constituted the optimal predictors of incident T2D after adjustment for covariates (hazards ratio 2.81 (95% confidence interval (CI) 2.05, 3.87); p < 0.001). +lncRNA target 36477451 hsa-mir-148 Carcinoma, Renal Cell CONCLUSION: Curcumin can inhibit the proliferation of renal cell carcinoma by regulating the miR-148/ ADAMTS18 axis through the suppression of autophagy in vitro and in vivo. There may exist a positive feedback loop between miR-148 and ADAMTS18 gene in RCC. +circulation_biomarker_diagnosis_ns 36476908 hsa-mir-451 beta-Thalassemia Compared with healthy controls, the expression levels of miR-451 was increased in peripheral blood of patients with beta-thalassemia and iron deficiency anemia, while the expression levels of miR-451 was decreased in patients with aplastic anemia and myelodysplastic syndrome. +circulation_biomarker_diagnosis_ns 36476908 hsa-mir-451 Anemia, Iron-Deficiency Compared with healthy controls, the expression levels of miR-451 was increased in peripheral blood of patients with beta-thalassemia and iron deficiency anemia, while the expression levels of miR-451 was decreased in patients with aplastic anemia and myelodysplastic syndrome. +circulation_biomarker_diagnosis_ns 36476908 hsa-mir-451 Anemia, Aplastic Compared with healthy controls, the expression levels of miR-451 was increased in peripheral blood of patients with beta-thalassemia and iron deficiency anemia, while the expression levels of miR-451 was decreased in patients with aplastic anemia and myelodysplastic syndrome. +circulation_biomarker_diagnosis_ns 36476908 hsa-mir-451 Myelodysplastic Syndromes Compared with healthy controls, the expression levels of miR-451 was increased in peripheral blood of patients with beta-thalassemia and iron deficiency anemia, while the expression levels of miR-451 was decreased in patients with aplastic anemia and myelodysplastic syndrome. +genetics_overexpression_promote 36476884 hsa-mir-29a Leukemia miR-29a-3p could target and regulate the expression of HDGF, while overexpression of HDGF reversed the inhibitory effect of miR-29a-3p overexpression on the proliferation and promotion effect on the apoptosis of leukemia cells E6-1. +genetics_overexpression_promote 36476884 hsa-mir-29a Precursor Cell Lymphoblastic Leukemia-Lymphoma CONCLUSION: Overexpression of miR-29a-3p can inhibit the proliferation and promote the apoptosis of ALL cells E6-1, and its mechanism may be related to the regulation of HDGF expression. +other 36476775 hsa-mir-146a Diabetes Mellitus, Type 2 The human host TB susceptibility genes TNFRSF10A, MSRA, GPR148, SLC37A3, PXK, PROK2, REV3L, PGM1, HIST3H2A, PLAC4, LETM2, and EMP2 and hsa-miR-146a microRNA were also differentially expressed at P(adj) <0.05. +other 36476775 hsa-mir-146a Tuberculosis The human host TB susceptibility genes TNFRSF10A, MSRA, GPR148, SLC37A3, PXK, PROK2, REV3L, PGM1, HIST3H2A, PLAC4, LETM2, and EMP2 and hsa-miR-146a microRNA were also differentially expressed at P(adj) <0.05. +circulation_biomarker_diagnosis_ns 36476595 hsa-mir-16 Schizophrenia A quantitative polymerase chain reaction measured the expression levels of the TTP and miR-16 in the peripheral blood (PB) of SCZ patients and healthy people. +transcription factor target 36476351 hsa-mir-125b Carcinoma, Non-Small-Cell Lung CONCLUSIONS: Overall, our findings demonstrated novel functions and mechanisms underlying DDP resistance in NSCLC through the TRIM28/miR-125b-5p/CREB1 axis. +circulation_biomarker_diagnosis_up 36476264 hsa-mir-375 Pancreatic Carcinoma Subcellular location analysis indicated that AK4P1 was mainly located in cytoplasm, in which AK4P1 might competitively bind to tumour suppressive miR-375 in pancreatic adenocarcinoma. +other 36476239 hsa-mir-19a Carcinoma, Hepatocellular Furthermore, a well-established circ_002136 ceRNA regulatory network was constructed, namely circ_002136 blocked miR-19a-3p expression, elevated RAB1A expression activity and stimulated HCC development. Finally, high levels of circ_002136 or RAB1A, as well as low levels of miR-19a-3p, negatively affected HCC patient survival. +circulation_biomarker_diagnosis_ns 36475430 hsa-mir-222 Pre-Eclampsia 3p expression in total plasma and plasma Exos, which both have high diagnostic efficiency for PE. +genetics_overexpression_promote 36475330 hsa-mir-122 Obesity The miRNA hsa-miR5p (p < 0.05) was overexpressed in the obese group. +other 36475295 hsa-mir-381 Breast Neoplasms A prediction model consisting of combination of miR-381 and Ki-67 and TN indicators could predict disease progression more effectively. +other 36474808 hsa-mir-140 Osteoarthritis Here we present functional studies of canonical microRNA3p and two of its most prevalent isomiRs, a 5' isomiR and a 3' isomiR, in an inflammation-induced model of osteoarthritis (OA). +genetics_GWAS 36474749 hsa-mir-21 Neonatal Sepsis AIM: The goal of this research was to find out the clinical weight of using miR181b-5p and miR21-5p expression levels as diagnostic and prognostic new genetic markers for neonatal sepsis. +genetics_GWAS 36474749 hsa-mir-181b Neonatal Sepsis AIM: The goal of this research was to find out the clinical weight of using miR181b-5p and miR21-5p expression levels as diagnostic and prognostic new genetic markers for neonatal sepsis. +lncRNA target 36474748 hsa-mir-221 Carcinoma, Hepatocellular CONCLUSIONS: The co-treatment with miR-122 mimic and miR-221 inhibitor amplifies the benefits of either treatment on HCC through targeting the SENP1 and ARF4 genes, respectively. +lncRNA target 36474748 hsa-mir-122 Carcinoma, Hepatocellular CONCLUSIONS: The co-treatment with miR-122 mimic and miR-221 inhibitor amplifies the benefits of either treatment on HCC through targeting the SENP1 and ARF4 genes, respectively. +circulation_biomarker_diagnosis_up 36474713 hsa-mir-103a Venous Thrombosis RESULTS: The upregulated expression levels of lncRNA XIST and HMGB1 and downregulated level of miR-103a-3p were found in the plasma of DVT patients and IL-1beta-treated HUVECs. CONCLUSION: lncRNA XIST sponged miR-103a-3p improving HMGB1 expression to exacerbate DVT by activating the ROS/NF-kappaB signaling pathway. +target gene 36474621 hsa-mir-204 Psoriasis Triptolide Inhibits Th17 Response by Upregulating microRNA-204-5p and Suppressing STAT3 Phosphorylation in Psoriasis. +transcription factor target 36474573 hsa-mir-27a Diabetic Nephropathies CONCLUSION: Compared with E2, daidzein efficiently ameliorated renal dysfunction, fibrosis, and apoptosis through modulation of miR-33a and miR-27a expression and their crosstalk with AT1R and MasR. +other 36474573 hsa-mir-33a Kidney Diseases Moreover, expression of renal miR-33a and miR-27a, collagen3A1 mRNA, and protein were up-regulated post-UUO. +transcription factor target 36474573 hsa-mir-27a Kidney Diseases CONCLUSION: Compared with E2, daidzein efficiently ameliorated renal dysfunction, fibrosis, and apoptosis through modulation of miR-33a and miR-27a expression and their crosstalk with AT1R and MasR. +other 36474573 hsa-mir-33a Diabetic Nephropathies Moreover, expression of renal miR-33a and miR-27a, collagen3A1 mRNA, and protein were up-regulated post-UUO. +circulation_biomarker_diagnosis_up 36474147 hsa-mir-552 Carcinoma, Hepatocellular METTL14 promoted circFUT8 m6A modification and facilitated its nuclear export to the cytoplasm, where M1 macrophages regulated the circFUT8/miR3p/CHMP4B pathway, thereby suppressing HCC progression. +genetics_overexpression_promote 36474029 hsa-mir-4731 Cardiomegaly The rescue experiments showed that miR-4731 overexpression attenuated the protective effects of circ_0018553 overexpression on the cardiac hypertrophy induced by Ang II; SIRT2 silencing also attenuated the protective effects of miR-4731 inhibition on the Ang II-induced cardiac hypertrophy. +genetics_knock down_promote 36473889 hsa-mir-27a Femur Head Necrosis The expressions of Runx2 in BMSCs and steroid-induced ONFH rats was significantly up-regulated, while IL-6, TNF-alpha, PPAR-gamma and ApoA5 were down-regulated with miR-27a overexpression. +circRNA target 36473706 hsa-mir-340 Cholangiocarcinoma CONCLUSION: Hsa_circ_0,019,054 deficiency could attenuate the proliferation and glycolysis of ICC cells via miR +genetics_knock down_promote 36473369 hsa-mir-96 Lung Neoplasms 5p expression, it could promote or inhibit the proliferation, invasion and metastasis of H1299 cells after LDB2 knockdown or overexpression and regulate the expression of cyclinD1, MMP9, Bcl-2, and Bax via ERK1/2 signaling pathway. +genetics_overexpression_promote 36473368 hsa-mir-653 Laryngeal Papilloma 5p efficiently inhibited the aggressive phenotypes of LP cells, which could be significantly reversed by BZW2 overexpression in LP cells. +other 36473367 hsa-mir-520e Osteosarcoma Moreover, we revealed the regulatory mechanism between Lnc-ZFAS1 and miR-520b/miR-520e-mediated RHOC and provided a novel clue for ameliorating osteosarcoma. CONCLUSIONS: Lnc-ZFAS1 acted sponger of miR-520b and miR-520e to promote RHOC, indicating that Lnc-ZFAS1/miR-520b/RHOC and Lnc-ZFAS1/miR-520e/RHOC axes might serve as potential therapeutic strategies against osteosarcoma. +other 36473367 hsa-mir-520b Osteosarcoma Moreover, we revealed the regulatory mechanism between Lnc-ZFAS1 and miR-520b/miR-520e-mediated RHOC and provided a novel clue for ameliorating osteosarcoma. CONCLUSIONS: Lnc-ZFAS1 acted sponger of miR-520b and miR-520e to promote RHOC, indicating that Lnc-ZFAS1/miR-520b/RHOC and Lnc-ZFAS1/miR-520e/RHOC axes might serve as potential therapeutic strategies against osteosarcoma. +lncRNA target 36471281 hsa-mir-29a Prostatic Neoplasms In summary, we demonstrated that LINC00852 played a key role in promoting the prostate cancer, and LINC00852/miR-29a-3p/JARID2 axis could be used as a target for prostate cancer treatment. +lncRNA target 36471277 hsa-mir-214 Esophageal Neoplasms CONCLUSIONS: These results further support the tumor-suppressive role of miR +other 36470669 hsa-mir-22 Carcinoma, Hepatocellular The mRNA expression of FGD5-AS1, LINC00858, SNHG16, and UBE4B was higher in the HCC cell lines (7721 and HepG2) than in the normal hepatocyte line (LO2), and the expression of hsa-miR3p mRNA showed a decreasing trend. +lncRNA target 36470227 hsa-mir-506 Neuralgia 3p had neuroprotective and inflammation-fighting functions in the tBPI rat model via CCL2/CCR2/NF-kappaB axis. +lncRNA target 36470227 hsa-mir-506 Brachial Plexus Avulsion 3p had neuroprotective and inflammation-fighting functions in the tBPI rat model via CCL2/CCR2/NF-kappaB axis. +other 36469564 hsa-mir-200 Biliary Tract Neoplasms Therefore, we aimed to comprehensively characterize this miR-200 family as a regulatory interface between EMT and immune evasion mechanisms in biliary tract cancer. +transcription factor target 36469307 hsa-mir-210 Obesity Thus, miR3p inhibition in ATMs could serve as a novel therapeutic strategy for managing obesity-induced type 2 diabetes. +circulation_biomarker_diagnosis_ns 36469203 hsa-mir-21 Lupus Erythematosus, Systemic CONCLUSION: The dysregulation of the circulating miR-210/miR-210/HIF-1alpha levels in SLE/hemolytic anemia patients advocated that the hypoxia pathway might have an essential role in the pathogenesis and complications of these diseases. +circulation_biomarker_diagnosis_ns 36469203 hsa-mir-21 Anemia, Hemolytic CONCLUSION: The dysregulation of the circulating miR-210/miR-210/HIF-1alpha levels in SLE/hemolytic anemia patients advocated that the hypoxia pathway might have an essential role in the pathogenesis and complications of these diseases. +circulation_biomarker_diagnosis_ns 36469203 hsa-mir-210 Lupus Erythematosus, Systemic CONCLUSION: The dysregulation of the circulating miR-210/miR-210/HIF-1alpha levels in SLE/hemolytic anemia patients advocated that the hypoxia pathway might have an essential role in the pathogenesis and complications of these diseases. +circulation_biomarker_diagnosis_ns 36469203 hsa-mir-210 Anemia, Hemolytic CONCLUSION: The dysregulation of the circulating miR-210/miR-210/HIF-1alpha levels in SLE/hemolytic anemia patients advocated that the hypoxia pathway might have an essential role in the pathogenesis and complications of these diseases. +exosome 36468636 hsa-mir-181a Osteosarcoma The results showed that exosomal miR-181a-5p derived from osteosarcoma cells induced polarization of M2 macrophages via targeting RORA. +other 36468451 hsa-mir-223 Colorectal Neoplasms Moreover, hsa-miR3p and hsa-miR-106a-5p showed an increased expression level of 5.58-fold and 9.66-fold in CRC samples, respectively. +other 36468451 hsa-mir-106a Colorectal Neoplasms Moreover, hsa-miR3p and hsa-miR-106a-5p showed an increased expression level of 5.58-fold and 9.66-fold in CRC samples, respectively. +lncRNA target 36468227 hsa-mir-214 Myocardial Reperfusion Injury MicroRNA3p protects against myocardial ischemia-reperfusion injury by targeting demethylase lysine demethylase 3A. +other 36468026 hsa-let-7 Pulmonary Disease, Chronic Obstructive AIFM1-FKBP1A pathway also indicates new hypotheses of COPD pathology. +circRNA target 36467610 hsa-mir-124 Anxiety Disorders 3p target gene, and increased EZH2 expression was involved in visceral hypersensitivity and anxiety in IBS-like rats by enhancing hippocampal synaptic plasticity. +circRNA target 36467610 hsa-mir-124 Irritable Bowel Syndrome 3p target gene, and increased EZH2 expression was involved in visceral hypersensitivity and anxiety in IBS-like rats by enhancing hippocampal synaptic plasticity. +target gene 36467343 hsa-mir-95 Uterine Cervical Neoplasms MiR-95-3p acts as a prognostic marker and promotes cervical cancer progression by targeting VCAM1. +therapeutic target 36467335 hsa-mir-345 Breast Neoplasms Silencing the expression of lncRNA SNHG15 may be a novel therapeutic approach in human breast cancer through regulating miR-345-5p. +transcription factor target 36467048 hsa-mir-125b Carcinoma, Non-Small-Cell Lung Mechanistically, Curcumol downregulated the expression of SP1 (specificity protein 1) while upregulated miR-125b-5p, followed by decreasing VEGFA expression in NSCLC cells. Collectively, our study revealed that Curcumol inhibited cell growth and angiogenesis of NSCLC in vitro and in vivo, possibly through SP1/miR-125b-5p/VEGFA regulatory mechanism. +lncRNA target 36467040 hsa-mir-185 Heart Failure 3p and the suppression of circ_0008494 inhibited the expression of Col1a1 by releasing miR +circulation_biomarker_prognosis_ns 36466111 hsa-mir-210 Carcinoma, Pancreatic Ductal Further detection of PDAC plasma exosomal miR-210 suggests that exosomal miR-210 expression was high and significantly associated with vascular invasion and TNM stage and was an independent risk factor for PDAC overall survival. +circulation_biomarker_diagnosis_ns 36465705 hsa-mir-210 Diabetes Mellitus, Type 2 This study is aimed at analyzing the correlation of circulating miR-210 level and obesity-associated T2DM and then investigating the underlying mechanism of circulating miR-210 in T2DM. +transcription factor target 36464444 hsa-mir-155 Cardiovascular Diseases In this work, a novel label-free and signal-off electrochemical biosensor based on efficient target-trigger T-structure recycling with dual strand displacement amplification (T-DSDA) was constructed for sensitive detection of miRNA-155 that related to cardiovascular diseases. +other 36464432 hsa-mir-455 Triple Negative Breast Neoplasms The ECL sensing system was used to detect miRNA3p in the triple-negative breast cancer tumor tissues. +circulation_biomarker_diagnosis_up 36463825 hsa-mir-1246 Carcinoma, Non-Small-Cell Lung Further investigation indicated that miR1246 was the most enriched microRNA in NSCLC-derived exosomes and mediated the partial effects of exosomes on microglia. Notably, miR1246 was also upregulated in the plasmatic exosomes of NSCLC patients. +lncRNA target 36463760 hsa-mir-206 Breast Neoplasms Taken together, our results proved that the lncRNA COX10-DT could function via the COX10-DT/miR-206/BDNF axis, thereby promoting the development of breast cancer. +lncRNA target 36463687 hsa-mir-146a Tendinopathy Targeting the AC108925/miR-146a-3p axis might be a latent way to treat tendinopathy. +genetics_knock down_promote 36463188 hsa-mir-181a Breast Neoplasms Gain- and loss-of-function experiments were performed to explore the role of miR-181a in BC progression with the involvement of the AKT signaling pathway. +other 36463118 hsa-mir-122 Hepatitis C RESULTS: miR-122 and miR-155 showed upregulation in HCV-4 patients compared to healthy controls while miR-196 and miR-29 showed downregulation in HCV-4 patients. +other 36463118 hsa-mir-29 Hepatitis C RESULTS: miR-122 and miR-155 showed upregulation in HCV-4 patients compared to healthy controls while miR-196 and miR-29 showed downregulation in HCV-4 patients. +other 36463118 hsa-mir-155 Hepatitis C RESULTS: miR-122 and miR-155 showed upregulation in HCV-4 patients compared to healthy controls while miR-196 and miR-29 showed downregulation in HCV-4 patients. +other 36463118 hsa-mir-196 Hepatitis C RESULTS: miR-122 and miR-155 showed upregulation in HCV-4 patients compared to healthy controls while miR-196 and miR-29 showed downregulation in HCV-4 patients. +other 36462649 hsa-mir-140 brachydactyly type D Results found that the expression of miR-140 in the articular cartilage of the KBD group was lower than that of the control group. Moreover, the occurrence of KBD might be related to the decreased expression of miR-140 in articular cartilage. +genetics_knock down_suppress 36462557 hsa-mir-125a Carcinoma, Renal Cell CONCLUSION: Circ_0000069 knockdown inhibited the carcinogenesis of RCC by regulating miR-125a-5p/SLC1A5 axis. +lncRNA target 36462499 hsa-mir-24 Melanoma 3p/MAPK1 axis in CMM, and revealed an alternative target for the diagnosis and treatment of CMM. +other 36462338 hsa-mir-197 Cirrhotic Cardiomyopathy 3p), were found to be the major potential genes involved in CCM regulation. +other 36462338 hsa-mir-483 Cirrhotic Cardiomyopathy 3p), were found to be the major potential genes involved in CCM regulation. +other 36462338 hsa-mir-885 Cirrhotic Cardiomyopathy 3p), were found to be the major potential genes involved in CCM regulation. +lncRNA target 36462326 hsa-mir-205 Prostatic Neoplasms 5p inhibitors, siErBB3 could oppose SC-triggered pro-apoptotic effects on PCa cells. +circulation_biomarker_diagnosis_ns 36462101 hsa-mir-375 Carcinoma, Non-Small-Cell Lung miR-375, SHOX2 methylation, smoking history, neuron-specific enolase (NSE), and CYFRA21-1 levels were risk factors for NSCLC; the risk of NSCLC increased 25.763 times for each unit increase in plasma miR-375 level (OR = 25.763, CI: 1.726-384.529), and the risk of NSCLC increased 4.096 times for each unit increase in SHOX2 methylation (OR = 4.096, CI: 1.195-14.036). +circulation_biomarker_diagnosis_ns 36461796 hsa-mir-203 psoriasis 1 It was observed that the mean serum miR-203 and miR-146a levels were increased in psoriasis patients. +circulation_biomarker_diagnosis_ns 36461796 hsa-mir-146a psoriasis 1 It was observed that the mean serum miR-203 and miR-146a levels were increased in psoriasis patients. +exosome 36461670 hsa-mir-217 Urinary Bladder Neoplasms We conclude that bladder cancer tissue-derived exosomes inhibit ferroptosis of T24 bladder cancer cells by transporting miR-217. +genetics_GWAS 36461613 hsa-mir-587 Adenocarcinoma of Lung Herein, the expression of lncRNA A2M-AS1, microRNA (miRNA) miR-587, and bone morphogenetic protein 3 (BMP3) in LUAD cell lines and tissues were detected by real-time quantitative polymerase chain reaction (RT-qPCR) and western blotting. +other 36461592 hsa-mir-124 Alzheimer Disease 3p. +other 36461592 hsa-mir-124 Hyperuricemia 3p. +lncRNA target 36460840 hsa-mir-155 Ischemic Stroke CONCLUSION: OIP5-AS1 suppressed oxidative stress and inflammatory response to alleviate cell injury caused by OGD/R induction in HMC3 and SH-SY5Y cells through regulating miR5p/IRF2BP2 axis, which might offer novel targeted molecules for ischemic stroke therapy. +transcription factor target 36460813 hsa-mir-205 Carcinoma, Hepatocellular The study clearly reflects that hsa-mir5p is the signature miRNA for positively regulating angiogenesis in HCC through VEGFA. +genetics_overexpression_promote 36460812 hsa-mir-146b Multiple Myeloma The inhibitory effects of NDNF upregulation on MM cell growth, colony formation, and migration were partially abolished by miR-146b-3p overexpression. +lncRNA target 36460802 hsa-mir-23a Glioma Collectively, these data suggest that GAS5 functions as a suppressor in GSCs by targeting the miR-23a/E-cadherin axis, which may be a promising therapeutic target against glioma. +genetics_knock down_promote 36460200 hsa-mir-4306 Intervertebral Disc Degeneration As expected, MIR4306 overexpression inhibited ECM degradation in degenerated NPCs by downregulating EPAS1. +circRNA target 36459832 hsa-mir-876 Esophageal Neoplasms CONCLUSION: Circ_0001686 contributed to the progression and radioresistance of esophagus cancer cells via regulating SPIN1 expression by targeting miR +genetics_overexpression_promote 36459592 hsa-mir-143 Dementia, Vascular Overexpression of miR +other 36459290 hsa-mir-21 Breast Neoplasms RESULTS: Our findings showed that the two miRNAs (miRNA-145, miRNA-382) were expressed at lower levels in BC sera than healthy control group, while miRNA-21 was expressed at higher levels in BC patients than control subjects. Area under ROC curves of BC samples revealed that AUC of miRNA-145, miRNA-382, miRNA-21, and glutamic acid was evaluated to equal 0.99, 1.00, 1.00 and 1.00, respectively. +circulation_biomarker_diagnosis_ns 36459290 hsa-mir-145 Breast Neoplasms CONCLUSION: Based on our results, we conclude that the detection of serum miRNA-145, -382 and -21 as a panel along with glutamic acid, and circulating HER2 concentrations could be useful as a non-invasive diagnostic profiling for early prediction of breast cancer in Egyptian patients. +other 36459290 hsa-mir-382 Breast Neoplasms RESULTS: Our findings showed that the two miRNAs (miRNA-145, miRNA-382) were expressed at lower levels in BC sera than healthy control group, while miRNA-21 was expressed at higher levels in BC patients than control subjects. Area under ROC curves of BC samples revealed that AUC of miRNA-145, miRNA-382, miRNA-21, and glutamic acid was evaluated to equal 0.99, 1.00, 1.00 and 1.00, respectively. +transcription factor target 36459288 hsa-mir-588 high grade glioma CONCLUSIONS: MiR-588 regulated the behaviors of hypoxic glioma cells by targeting ROBO1. +lncRNA target 36459288 hsa-mir-588 Carcinoma, Hepatocellular MicroRNA-588 and its potential target Roundabout-directed receptor 1 (ROBO1) have been reported to promote tumor invasion and proliferation in diseases such as gastric, pancreatic and hepatocellular carcinoma, while their function in GBM and response to hypoxic states remain elusive. +lncRNA target 36459288 hsa-mir-588 Glioblastoma MicroRNA-588 and its potential target Roundabout-directed receptor 1 (ROBO1) have been reported to promote tumor invasion and proliferation in diseases such as gastric, pancreatic and hepatocellular carcinoma, while their function in GBM and response to hypoxic states remain elusive. +lncRNA target 36459268 hsa-mir-30 Colorectal Neoplasms 3p/CNBP axis in CRC, highlighting the potential of circPACRGL as a therapeutic target for colorectal cancer. +other 36459254 hsa-mir-155 Periodontitis The result suggested that miRNA-155 does not affect the expression of MITF gene in the process of osteoclastogenesis in localized stage III/IV periodontitis within this study design and limitations. +lncRNA target 36458392 hsa-mir-449a Peripheral Nerve Injuries CONCLUSIONS: BMSCs can modulate NF-kappaB signaling pathway by targeting miR-449a, so as to reduce the inflammatory response to peripheral nerve injury and repair nerve injury. +genetics_GWAS 36457982 hsa-mir-155 Behcet Syndrome MiR-146a (rs2910164) polymorphism was a risk factor for susceptibility to BD in dominant, recessive and additive models of inheritance (all p < 0.001), while the miR-155 (rs767649) polymorphism was a risk factor in the recessive model only (p = 0.021). +genetics_GWAS 36457982 hsa-mir-146a Behcet Syndrome MiR-146a (rs2910164) polymorphism was a risk factor for susceptibility to BD in dominant, recessive and additive models of inheritance (all p < 0.001), while the miR-155 (rs767649) polymorphism was a risk factor in the recessive model only (p = 0.021). +other 36457981 hsa-mir-125b Cholesteatoma Low expression of microRNA-125b enhances the expression of STAT3 and contributes to cholesteatoma growth. +lncRNA target 36457977 hsa-mir-20a Osteoporosis MATERIAL AND METHODS: The expression of MALAT1 and miR-320a was determined using RT-PCR in bone tissue derived from female SD (Sprague Dawley) rats with osteoporosis. CONCLUSIONS: Downregulated MALAT1 and upregulated miR-320a expression play an important role in the pathological process of osteoporosis, via inhibition of the osteogenic differentiation of BMSCs. +other 36457973 hsa-mir-23b Osteoporosis It has been reported previously that miR-23b-3p is involved in osteoporosis and in regulation of differentiation of osteoblasts. +other 36457880 hsa-let-7e Inflammation CONCLUSION: A possible linkage of sialic acid on miR-320a and let-7e regulation was observed in the glial cell line as proinflammatory factors in the inflammation pathway. +other 36457880 hsa-mir-20a Inflammation CONCLUSION: A possible linkage of sialic acid on miR-320a and let-7e regulation was observed in the glial cell line as proinflammatory factors in the inflammation pathway. +circulation_biomarker_diagnosis_ns 36457743 hsa-mir-222 Carcinoma, Hepatocellular The serum and tissue expression of miRNAs (Let-7a, miR-26a, miR-124, miR-155, miR-221, miR-222, and miR-340) were differentially expressed in HCC patients (p < 0.05). +other 36457244 hsa-mir-454 Pancreatic Carcinoma RESULTS: We revealed CDK6 might be an oncogene in PC, and the HOXA11-AS /NR2F1-AS1- miR3p axis was identified as the possible upstream ncRNA-associated pathway of CDK6 in PC. +other 36457077 hsa-mir-24 Colorectal Neoplasms In follow-up experiments, we demonstrate that miR3p promotes CRC cell survival in multiple cell contexts. +genetics_knock down_promote 36457055 hsa-mir-8114 Seizures Moreover, both circ_0001293 knockdown and miR-8114 overexpression reversed the beneficial effects of HsTx2 on inflammation, epilepsy progression, and the MAPK and NF-kappaB signaling pathways in vivo. CONCLUSIONS: HsTx2 suppressed PTZ-induced epilepsy by ameliorating inflammation in astrocytes via the circ_0001293/miR-8114/TGF-beta2 axis. +transcription factor target 36457036 hsa-mir-378a Colorectal Neoplasms Phenotypically, by reducing polyamine synthesis, miR-378a induced apoptosis and inhibited proliferation and migration of CRC cells, while disrupting the association of miR-378a with FOXQ1 and ODC1 offset the effects of miR-378a, suggesting that FOXQ1 and ODC1 were required for miR-378a to inhibit CRC cell growth. +lncRNA target 36457028 hsa-mir-133a Uterine Cervical Neoplasms 369 cluster with a positive feedback way which targeted c-Rel itself and its positive regulator AKT3. +lncRNA target 36457028 hsa-mir-379 Uterine Cervical Neoplasms 369 cluster with a positive feedback way which targeted c-Rel itself and its positive regulator AKT3. +exosome 36457020 hsa-mir-142 hereditary diffuse gastric cancer For accurate diagnosis of gastric cancer patients, a combination of LDT-CHA and a panel of four sEV-miRNAs (sEV-miR-1246, sEV-miR-21, sEV-miR +other 36456979 hsa-mir-576 Esophageal Neoplasms 5p/AHR were critical molecular pathways related to the radiosensitivity of esophageal cancer. +transcription factor target 36456413 hsa-mir-663a Fibrosis CONCLUSION: Our study identified lnc-C18orf26-1 and miR-663a as promising therapeutic targets for hepatic fibrosis. +circulation_biomarker_prognosis_ns 36456138 hsa-mir-21 Ovarian Neoplasms CONCLUSION: Serum levels of miR-1 and miR-21 might serve as promising biomarkers in the diagnosis of ovarian cancer. +circulation_biomarker_prognosis_ns 36456138 hsa-mir-1 Ovarian Neoplasms CONCLUSION: Serum levels of miR-1 and miR-21 might serve as promising biomarkers in the diagnosis of ovarian cancer. +exosome 36455873 hsa-mir-584 Postoperative Cognitive Complications CONCLUSIONS: Sevoflurane-induced POCD-associated exosomes delivered miR +other 36455651 hsa-mir-152 Obesity 3p were associated with insulin resistance. +other 36455651 hsa-mir-423 Obesity 3p were associated with insulin resistance. +other 36455323 hsa-mir-6238 Acute Lung Injury Collectively, our findings suggest that miR-6238 is a novel regulator of pulmonary inflammation and a putative biomarker that distinguishes PM-induced ALI from endotoxin (LPS/PTG)-mediated ALI. +genetics_overexpression_suppress 36455140 hsa-mir-143 Wilms Tumor Meanwhile, overexpression of k-Ras reversed the inhibitory effects on WT cells induced by miR +lncRNA target 36454533 hsa-mir-210 Cholangiocarcinoma It was further confirmed in vivo that miR-210 shuttled by tumor cell-derived EVs could specifically inhibit RECK expression, which promotes growth, metastasis and chemoresistance of CCA cells. +genetics_knock down_promote 36454505 hsa-mir-433 Glioma 3p overexpression-mediated effects on glioma cell clonogenicity, migration, and apoptosis. +circulation_biomarker_diagnosis_down 36454178 hsa-mir-191 Alzheimer Disease 5p in plasma/serum has been identified as a novel and promising noninvasive diagnostic biomarker for AD. +other 36454035 hsa-let-7d Pulmonary Fibrosis, Idiopathic RESULTS: U-IPFexo or MF-IPFexo expressed miR-let-7d, miR-29a-5p, miR-181b-3p and miR-199a-3p consistent with previous reports of miRNA expression obtained from lung tissue/sera from patients with IPF. +other 36454035 hsa-mir-29a Pulmonary Fibrosis, Idiopathic RESULTS: U-IPFexo or MF-IPFexo expressed miR-let-7d, miR-29a-5p, miR-181b-3p and miR-199a-3p consistent with previous reports of miRNA expression obtained from lung tissue/sera from patients with IPF. +other 36454035 hsa-mir-181b Pulmonary Fibrosis, Idiopathic RESULTS: U-IPFexo or MF-IPFexo expressed miR-let-7d, miR-29a-5p, miR-181b-3p and miR-199a-3p consistent with previous reports of miRNA expression obtained from lung tissue/sera from patients with IPF. +genetics_knock down_suppress 36453878 hsa-mir-361 Esophageal Neoplasms 3p inhibitor rescued the anti-tumour effect of BBOX1-AS1 knockdown on the progression of EC. +other 36452459 hsa-let-7b Leukemia CTDSP1 was significantly downregulated in T-ALL compared to normal controls, which might be originated from the hyperediting of hsa-let-7b-5p in T-ALL. +other 36452459 hsa-mir-21 Leukemia 5p decreased in chronic lymphocytic leukemia patients with radiation treatments. +other 36452459 hsa-mir-155 Leukemia 5p decreased in chronic lymphocytic leukemia patients with radiation treatments. +other 36452144 hsa-mir-214 Schimke immunoosseous dysplasia By constructing miRNA96mRNA interaction networks associated with Sika Deer immunity, we found that miRNAs (miR-148a, miR-26a, miR-214, let-7b, etc.) and mRNAs (CD6, TRIM38, C3, CD163, etc.) might play an important role in the immune response of Sika Deer spleen. +other 36452144 hsa-mir-148a Schimke immunoosseous dysplasia By constructing miRNA96mRNA interaction networks associated with Sika Deer immunity, we found that miRNAs (miR-148a, miR-26a, miR-214, let-7b, etc.) and mRNAs (CD6, TRIM38, C3, CD163, etc.) might play an important role in the immune response of Sika Deer spleen. +other 36452144 hsa-let-7b Schimke immunoosseous dysplasia By constructing miRNA96mRNA interaction networks associated with Sika Deer immunity, we found that miRNAs (miR-148a, miR-26a, miR-214, let-7b, etc.) and mRNAs (CD6, TRIM38, C3, CD163, etc.) might play an important role in the immune response of Sika Deer spleen. +other 36452144 hsa-mir-26a Schimke immunoosseous dysplasia By constructing miRNA96mRNA interaction networks associated with Sika Deer immunity, we found that miRNAs (miR-148a, miR-26a, miR-214, let-7b, etc.) and mRNAs (CD6, TRIM38, C3, CD163, etc.) might play an important role in the immune response of Sika Deer spleen. +other 36451863 hsa-mir-92a-2 Multiple Myeloma 3p expression. +lncRNA target 36451861 hsa-mir-126 Triple Negative Breast Neoplasms Results: Sonoporation of targeted jNP-payload-MBs delivers functional reporter-DNA imparting tumor-fluorescence, and micro-RNA126 reducing non-druggable KRAS in PDAC-Panc1 and TNBC-MB231 xenografted tumors. +lncRNA target 36451861 hsa-mir-126 Pancreatic Carcinoma Results: Sonoporation of targeted jNP-payload-MBs delivers functional reporter-DNA imparting tumor-fluorescence, and micro-RNA126 reducing non-druggable KRAS in PDAC-Panc1 and TNBC-MB231 xenografted tumors. +other 36451157 hsa-mir-17 Neuroectodermal Tumors, Primitive The sperm sRNA sequencing revealed that the expression of the developmental miR92 cluster and the Sfmbt2 miRNA cluster was downregulated in the OEE group. +lncRNA target 36451051 hsa-mir-580 Stomach Neoplasms SOX2-activated Linc-ROR serves as a cancer suppressor to restrain GCa progression in vitro via the miR +genetics_knock down_suppress 36450557 hsa-mir-214 Reperfusion Injury, Ischemia SOX6 knockdown overturned the circTRRAP overexpression-induced effects in AC16 cardiomyocytes.In conclusion, the silence of circTRRAP was implicated in Sal B-mediated cardioprotective effects against I/R injury by regulating the miR3p/SOX6 axis. +circulation_biomarker_diagnosis_ns 36450556 hsa-mir-22 Graft Occlusion, Vascular Peripheral blood samples were acquired from patients with in-stent restenosis (ISR) after percutaneous coronary intervention (PCI), with subsequent quantitative reverse transcription (qRT) -polymerase chain reaction (PCR) and Western blot analyses of miR +circulation_biomarker_diagnosis_ns 36450556 hsa-mir-22 Ciliary Motility Disorders The peripheral blood of patients with ISR after PCI had low expression of miR +transcription factor target 36450556 hsa-mir-22 Cardiovascular Diseases Conclusively, miR3p could repress VSMC proliferation, phenotypic transformation, and migration by targeting TOMM40, which might be a possible treatment candidate for restenosis after PCI in patients with cardiovascular disease. +circulation_biomarker_diagnosis_ns 36449688 hsa-mir-590 Reperfusion Injury, Renal Ischemia RESULTS: miR3p was highly enriched in the plasma exosomes of young AKI patients after cardiac surgery. +other 36449366 hsa-mir-122 Hepatitis C MicroRNA-122 (miR-122) is the most abundant miRNA in the liver and has been linked to the development of hepatocellular carcinoma and hepatitis C virus (HCV) infection. +lncRNA target 36449143 hsa-mir-488 Stomach Neoplasms Overall, HULC re-expression elicited by miR-488 inhibition can enhance EZH2-H3K27me3 enrichment in the p53 promoter and repress the p53 expression, thus promoting the growth and metastasis of GC. +transcription factor target 36448837 hsa-mir-15a Acute Lung Injury The PRKCA/miR-15a-5p/PDK4 axis alleviated ALI caused by sepsis by promoting mitophagy and repressing anti-inflammatory response. +transcription factor target 36448837 hsa-mir-15a Sepsis The PRKCA/miR-15a-5p/PDK4 axis alleviated ALI caused by sepsis by promoting mitophagy and repressing anti-inflammatory response. +exosome 36448712 hsa-mir-518a Ovarian Neoplasms OC-derived exosomal circNFIX promoted angiogenesis by regulating the Janus-activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) pathway via miR-518a-3p/TRIM44 axis in HUVECs. +other 36448711 hsa-mir-223 Liver Neoplasms Herein, we propose a simple and sensitive mass spectrometric method for the multiplex detection of nucleic acid and protein, in which liver cancer-related biomarkers miRNA 223 and alpha-fetoprotein (AFP) were selected as model analytes. +genetics_GWAS 36448327 hsa-mir-124 Ischemic Stroke Finally, the suppressed of PARP1 was induced by gain-binding ability of miR5p through 3'UTR directly binding.Conclusions: In conclusion, our study demonstrates that the SNP rs8679 in PARP1 3'-UTR might act as a protective factor for the outcome of patients with ischemic stroke. +other 36447429 hsa-mir-223 Melanoma miR-181a-3p and miR-223-3p notably reduced the PD-L1 protein levels in melanoma cells. +other 36447429 hsa-mir-181a Melanoma miR-181a-3p and miR-223-3p notably reduced the PD-L1 protein levels in melanoma cells. +target gene 36447254 hsa-mir-506 Stomach Neoplasms Blocking lncRNA-SNHG16 sensitizes gastric cancer cells to 5-Fu through targeting the miR-506-3p-PTBP1-mediated glucose metabolism. +lncRNA target 36447214 hsa-mir-200b Stomach Neoplasms The StarBase database was used to predict that 3 pseudogenes and 7 lncRNAs might inhibit the hsa-miR-200b-3p-COL5A2 axis in gastric cancer. CONCLUSIONS: We elucidated the regulatory role of the pseudogenes/lncRNA-hsa-miR-200b-3p-COL5A2 network in gastric cancer progression and constructed a nomogram. +circulation_biomarker_diagnosis_ns 36446758 hsa-mir-148a Bone Diseases Finally, the miR-148a level was found to be positively correlated with beta-CTX in postmenopausal osteoporosis (PMOP) serum specimens. In osteoclast-related bone metabolic diseases such as PMOP, miR-148a may be an attractive therapeutic target in the future. +other 36446162 hsa-mir-4455 Cognitive Dysfunction The diagnostic index taking a ratio of hsa-miR-4455 to hsa-let-7b-3p predicted aMCI patients against healthy subjects with 97% overall accuracy. +other 36446162 hsa-let-7b Cognitive Dysfunction The diagnostic index taking a ratio of hsa-miR-4455 to hsa-let-7b-3p predicted aMCI patients against healthy subjects with 97% overall accuracy. +lncRNA target 36446154 hsa-mir-1322 Myocardial Ischemia CONCLUSION: Our results suggested that miR-1322 can protect against the myocardial ischemia via LRP8/PI3K/AKT pathway. +genetics_overexpression_suppress 36445955 hsa-mir-34a Carcinoma, Hepatocellular Overexpression of miR-34a-5p counteracts CSC properties and enhances radiosensitivity in HCC. +other 36445630 hsa-mir-6085 Cerebral Infarction Celastrol ameliorated OGD/R-induced HBMEC apoptosis and oxidative stress by circDLGAP4/miR-6085/GDF11 pathway, supporting the use of Celastrol as a therapeutic agent for cerebral infarction. +genetics_knock down_promote 36445573 hsa-mir-490 Carcinoma, Non-Small-Cell Lung CONCLUSION: Knockdown of MAPKAPK5-AS1 inhibited the aggressive tumor phenotypes through miR +lncRNA target 36445120 hsa-let-7b Colonic Neoplasms Let-7b-5p was found to inhibit proliferation, migration, and invasion of colon cancer cells targeting NKD1. This research revealed a novel mechanism by which the let-7b-5p-NKD1-APC-beta-catenin signaling pathway inhibited colon cancer cell progression. +genetics_overexpression_promote 36445107 hsa-mir-548ag Obesity Our previous study observed that miR-548ag was significantly overexpressed in the sera of obese individuals. +genetics_overexpression_promote 36445107 hsa-mir-548ag Endometrial Neoplasms Our previous study observed that miR-548ag was significantly overexpressed in the sera of obese individuals. +tissue_expression_ns 36444993 hsa-mir-181a-2 Myelodysplastic Syndromes Although abnormal microRNA expression has been implicated in MDS, the exact role of miR-181a3p has not been entirely elucidated. Here, we investigated miR-181a3p levels in bone marrow (BM), and described its utility as a potential indicator for MDS diagnosis and prognosis. METHODS: We evaluated miR-181a3p expression in BM samples of 54 newly diagnosed MDS cases, 16 sAML patients and 32 healthy donors and then assessed its association with clinical characteristics and its potential value for MDS diagnosis and prognosis. RESULTS: Compared with healthy controls, miR-181a3p levels were decreased in the total cohort of MDS patients. Additionally, in MDS patients with secondary AML (sAML), miR-181a3p was over-expressed relative to levels in those without this form. Further, multivariate analysis indicated that miR-181a3p was an independent prognostic index for MDS with respect to OS. CONCLUSION: Decreased miR-181a3p expression in MDS patients may be considered as one of the underlying markers reflecting MDS progression and prognosis. +genetics_knock down_promote 36444938 hsa-mir-6838 Uterine Cervical Neoplasms Functional investigations revealed that CERS6-AS1 knockdown inhibited proliferation and invasion, and promoted apoptosis in CC cells, which was reversed by miR +genetics_overexpression_promote 36444911 hsa-mir-708 Retinoblastoma Furthermore, retinoblastoma cells overexpressing miR-708 exhibited a markedly lower migratory rate and invasiveness compared to negative control cells. +circRNA target 36444635 hsa-mir-518a Periodontal Diseases CONCLUSION: Circ_0138960 promoted LPS-induced dysfunction in PDLCs by targeting miR-518a-5p/HDAC6 axis, which provided novel potential therapeutic targets for periodontitis. +genetics_GWAS 36444590 hsa-mir-423 Breast Neoplasms The goal of this study was to determine if there was a link between the miR-423 rs6505162 gene variation and breast cancer susceptibility among Egyptian patients. CONCLUSION: Our data suggest that miR-423 rs6505162 polymorphism could be a potential risk factor in the pathogenesis of breast cancer among Egyptian population. +circRNA target 36444162 hsa-mir-1236 Osteosarcoma CONCLUSION: Circ_0000253 promotes OS cell proliferation and suppresses cell apoptosis via regulating the miR +circRNA target 36443854 hsa-mir-667 Non-alcoholic Fatty Liver Disease 5p/SIRT1 axis reversed its effects, suggesting that targeting circLDLR/miR +other 36443711 hsa-mir-142 Breast Neoplasms 5p /RAC1/PAK1 axis. +genetics_overexpression_promote 36442661 hsa-mir-20b Carcinoma, Hepatocellular Mechanically, circITCH elevated PTEN expression to inactivate the PI3K/Akt signals through negatively regulating miR-20b-5p in HCC, and upregulating miR-20b-5p or inhibiting PTEN abolished the enhancing effect of circITCH overexpression on sorafenib-induced cytotoxicity in sorafenib-resistant HCC cells. CONCLUSION: Taken together, this study proves that circITCH enhances sorafenib-sensitivity in sorafenib-resistant HCC cells via regulating the miR-20b-5p/PTEN/PI3K/Akt signaling cascade, which highlights the potential value of circITCH as a target for enhancing the sorafenib-sensitivity in HCC. +transcription factor target 36442170 hsa-mir-1 Breast Neoplasms ErbB4-miR1/2 were downregulated in breast and colon tumor tissues and also in different cancerous cells. CONCLUSIONS: ErbB4-miR1/2 are novel tumor suppressor miRNAs which attenuate ErbB/PI3K signaling in breast and colon cancer cells. +transcription factor target 36442170 hsa-mir-2 Breast Neoplasms ErbB4-miR1/2 were downregulated in breast and colon tumor tissues and also in different cancerous cells. CONCLUSIONS: ErbB4-miR1/2 are novel tumor suppressor miRNAs which attenuate ErbB/PI3K signaling in breast and colon cancer cells. +genetics_knock down_promote 36441929 hsa-mir-140 Intracranial Aneurysm Knockdown of miR-140 alleviates the development of intracranial aneurysms. +genetics_overexpression_suppress 36441170 hsa-mir-139 Urinary Bladder Neoplasms Subsequent experimental results presented that overexpressing KIF18B could reverse inhibitory effect of overexpressing miRNA +genetics_overexpression_promote 36441004 hsa-mir-93 Urinary Bladder Neoplasms Overexpression of PAFAH1B1 could efficiently reverse the effects of miR +other 36440973 hsa-mir-223 Complex Regional Pain Syndromes In particular, microRNAs, such as miR-223, decreased in CRPS, have been described only in cross-sectional studies. CONCLUSION: We identified progressively reduced miR-223 as a putative biomarker of chronic CRPS pain. +transcription factor target 36440907 hsa-mir-124 Inflammatory Bowel Diseases Collectively, Rauwolfia-derived PPs limited miR3p and targeted RBP4 and reduced the binding potency of RBP4 to NLRP3 to inhibit NLRP3-mediated pyroptosis, resulting in the alleviation of colonic epithelial cell pyroptosis and mucosal damages in UC. +genetics_overexpression_promote 36440854 hsa-mir-1 renal fibrosis NEAT1 silencing or overexpression of miR-31 alleviated renal fibrosis in vivo. +other 36440749 hsa-mir-146a Osteoarthritis Furthermore, two microRNAs: miR-140 and miR-146a were elevated after TAX treatment in OA rat model. +other 36440749 hsa-mir-140 Osteoarthritis Furthermore, two microRNAs: miR-140 and miR-146a were elevated after TAX treatment in OA rat model. +circulation_biomarker_diagnosis_ns 36440364 hsa-mir-146a Arthritis, Rheumatoid FLS were cocultured with WJR-containing serum to observe the effects of miRNA-146a-mediated autophagy via the PI3K/AKT/mTOR pathway on CIA-affected rats. +other 36440217 hsa-mir-21 Osteoporosis, Postmenopausal Our findings suggest that whole-body vibration is a sufficient mechanical stimulus for altering c-miR5p expression, whereas a high intensity resistance exercise protocol did not elicit any c-miRNA responses in postmenopausal women. +other 36440215 hsa-mir-218 Diabetes, Gestational The prediction performance of hsa-miR-517a-3p|hsa-miR-517b-3p, hsa-miR5p, and hsa-let7a-3p was slightly better than GDM classic risk factors (age, BMI, familial history of type 2 diabetes, history of GDM or macrosomia, and HbA1c) (AUC 0.78 vs. +other 36440215 hsa-mir-517b Diabetes, Gestational The prediction performance of hsa-miR-517a-3p|hsa-miR-517b-3p, hsa-miR5p, and hsa-let7a-3p was slightly better than GDM classic risk factors (age, BMI, familial history of type 2 diabetes, history of GDM or macrosomia, and HbA1c) (AUC 0.78 vs. +other 36440215 hsa-let-7a Diabetes, Gestational The prediction performance of hsa-miR-517a-3p|hsa-miR-517b-3p, hsa-miR5p, and hsa-let7a-3p was slightly better than GDM classic risk factors (age, BMI, familial history of type 2 diabetes, history of GDM or macrosomia, and HbA1c) (AUC 0.78 vs. +other 36440215 hsa-mir-517a Diabetes, Gestational The prediction performance of hsa-miR-517a-3p|hsa-miR-517b-3p, hsa-miR5p, and hsa-let7a-3p was slightly better than GDM classic risk factors (age, BMI, familial history of type 2 diabetes, history of GDM or macrosomia, and HbA1c) (AUC 0.78 vs. +lncRNA target 36440209 hsa-mir-107 Diabetes Mellitus, Type 1 CONCLUSION: Our results suggest that lncRNA such as lncRNA PVT1, LINC00960 and hsa-miR-107 might be involved in inflammation response in T1DM, and the former lncRNA chose in the present study may serve as novel biomarkers and potential targets for the diagnosis and treatment of T1DM. +target gene 36439901 hsa-mir-136 Uterine Cervical Neoplasms Circular RNA circ_0004488 Increases Cervical Cancer Paclitaxel Resistance via the miR-136/MEX3C Signaling Pathway. +other 36439523 hsa-mir-550a Adenocarcinoma of Lung A nomogram consisting of BMI, history of chronic pain, miR 550a-3p, and VAS2d predicted the risk of CPSP after VATS in patients with lung adenocarcinoma. +other 36438900 hsa-mir-125b Periodontitis VIM may be a potential biomarker in the analysis of linked hub gene regulatory networks, and hsa-mir-21 and hsa-mir-125b are predicted to be associated in PD and aging. +other 36438900 hsa-mir-21 Periodontitis VIM may be a potential biomarker in the analysis of linked hub gene regulatory networks, and hsa-mir-21 and hsa-mir-125b are predicted to be associated in PD and aging. +circulation_biomarker_diagnosis_up 36438898 hsa-mir-125b Vitiligo RESULTS: Compared with the healthy control group, the expression of miR-125b-5p in the tissues and serum of vitiligo patients was upregulated, and the expression of MITF was downregulated; compared with PIG1 cells, the expression of miR-125b-5p and MITF in the PIG3V group was consistent with the above. +transcription factor target 36438895 hsa-mir-877 Breast Neoplasms 5p inhibits epithelial mesenchymal transformation, cell proliferation, and invasion of BC cells via downregulating FGB. +circulation_biomarker_diagnosis_ns 36437340 hsa-mir-652 Pre-Eclampsia 3p, the level of SUMO 1-4 and UBC9 in the placenta, reduced concentration of PlGF, and increased sFlt-1/PlGF ratio in the blood of pregnant women with early-onset preeclampsia, which attests to the presence of a regulatory mechanism along the axis of miR +other 36437242 hsa-mir-17 skin melanoma Seven immune-related CM prognostic molecules, including three mRNAs (SUCO, BTN3A1 and TBC1D2), three lncRNAs (HLA-DQB1-AS1, C9orf139 and C22orf34) and one miRNA (hsa-miR5p), were screened by differential expression analysis, ceRNA network analysis, LASSO Cox regression analysis and univariate Cox regression analysis. +genetics_knock down_promote 36436795 hsa-mir-1227 Osteoarthritis 3p inhibitor reversed the effect of circ_0114876 knockdown on the OA chondrocytes, and ADAM10 overexpression reversed the effect of miR +circulation_biomarker_diagnosis_down 36436490 hsa-mir-205 Kidney Diseases Hence, our study sought to study the possible modulatory effect of rosuvastatin on miR-205 and its downstream target, Egl-9 family hypoxia-inducible factor 2 (EGLN2) to combat oxidative and endoplasmic reticulum (ER) stresses as pivotal contributors to colistin-associated renal injury. +transcription factor target 36436380 hsa-mir-129 Vitamin B Deficiency These data indicates that miR3p affected ferroptosis under Se deficiency conditions through the SLC7A11 pathway. +genetics_overexpression_suppress 36436380 hsa-mir-129 Siderosis 3p/SLC7A11 axis could involve in the process of ferroptosis, our further research showed that overexpression of miR +other 36436380 hsa-mir-129 Deficiency Diseases The results showed that the expression level of miR3p mRNA in Se-deficient liver was significantly increased. +other 36436380 hsa-mir-129 Liver Diseases The results showed that the expression level of miR3p mRNA in Se-deficient liver was significantly increased. +lncRNA target 36436369 hsa-mir-223 Non-alcoholic Fatty Liver Disease These results indicated that PAMK could relieve inflammatory liver tissue damage after LPS treatment and downregulate the level of inflammation factors via miR-223/NLRP3 axis, thus playing a liver protective role in liver inflammation injury in goslings. +transcription factor target 36436343 hsa-mir-338 Colorectal Neoplasms 3p, which may be a therapeutic target for CRC. +circRNA target 36436315 hsa-mir-506 Triple Negative Breast Neoplasms 3p was found to suppress proliferation and facilitate apoptosis of TNBC cells. +transcription factor target 36436291 hsa-mir-28 Otitis Media Furthermore, in vivo experiments confirmed that CF-lenti-miR-28 inhibitor-Evs injection down-regulated the number of TRAP (+) MNCs and inhibited tooth movement of OTM rats. +genetics_knock down_promote 36436251 hsa-mir-204 Aortic Aneurysm, Abdominal 5p levels and reduced the expression of Mekk3, whereas lincRNA-p21 overexpression had the opposite effect. +other 36435921 hsa-mir-34a Esophageal Squamous Cell Carcinoma CONCLUSION: Our results not only provide evidence that HPV16 E6 promotes cell proliferation, migration, and invasion in ESCC, but also suggests a correlation between HPV infection and E6AP, p53 and miR-34a expression. +genetics_knock down_suppress 36435914 hsa-mir-140 Osteoarthritis CONCLUSION: Circ_0136474 knockdown alleviated IL-1beta-triggered CHON-001 cell damage through modulation of miR3p/MECP2 axis, indicating a new target for treatment of OA. +other 36435866 hsa-mir-205 Carcinoma, Hepatocellular CONCLUSION: Our data indicate that a LINC00152/miR5p/CXCL11 axis in HCC CAFs can affect the proliferative and migrative abilities of HCC cells in vitro and HCC tumor growth in vivo. +circulation_biomarker_diagnosis_up 36435781 hsa-mir-150 Lupus Erythematosus, Systemic 5p in peripheral blood mononuclear cells of SLE. +lncRNA target 36435763 hsa-mir-145 Femur Head Necrosis In conclusion, miR-145 regulates the proliferation and differentiation of glucocorticoid-induced BMSC cells through GABARAPL1 and pharmacologically inhibit targeting miR-145 may provide new aspect for the treatment of SANFH. +lncRNA target 36435226 hsa-mir-370 Liver Cirrhosis 3p/Irak2 axis might be a novel identifier and therapeutic target for HF. +lncRNA target 36434857 hsa-mir-342 Brain Ischemia 5p on cerebral ischemia injury as well as novel targets for stroke. +circulation_biomarker_diagnosis_ns 36434610 hsa-mir-148a Prostatic Neoplasms Here, we investigated the correlation between the serum miR-148a-3p and miR5p expression levels and cancer recurrence in PCa patients, aiming to identify new biomarkers for diagnosis and predicting postoperative recurrence of prostate cancer. +circulation_biomarker_diagnosis_ns 36434610 hsa-mir-485 Prostatic Neoplasms CONCLUSION: Pre-surgery serum miR-148a-3p level positively correlates while miR +lncRNA target 36434587 hsa-mir-101 Urinary Bladder Neoplasms The promoting effects of NEAT1 on bladder cancer cells were reversed by miR-101 upregulation, and inhibition of miR-101 enhanced the effects of NEAT1. +other 36434577 hsa-mir-671 Lung Neoplasms CONCLUSIONS: Elevated circ_0017109 expression promotes tumor progression of NSCLC by modulating miR5p/FZD4/beta-catenin axis. +circulation_biomarker_diagnosis_up 36434569 hsa-mir-15a Primary Ovarian Insufficiency RESULTS: miR-15a-5p was increased whilst Stat3 was decreased in the serum of POI patients and SS-induced KGN cells. +exosome 36434177 hsa-mir-375 Prostatic Neoplasms In conclusion, our study suggests that cancer-derived exosomal miR-375 targets DIP2C, activates the Wnt signaling pathway, and promotes osteoblastic metastasis and PCa progression. +other 36433987 hsa-mir-124 Atherosclerosis Our findings indicate that hsa-miR-124 and miR-16 have potential for use as therapeutic candidates in the treatment of atherosclerosis. +other 36433987 hsa-mir-16 Atherosclerosis Our findings indicate that hsa-miR-124 and miR-16 have potential for use as therapeutic candidates in the treatment of atherosclerosis. +transcription factor target 36433652 hsa-mir-10b Colorectal Neoplasms The analysis of the three miRNAs targeting IL1B, CXCL8, IL1A, and CSF2 showed that miR5p was upregulated in T compared with PT, whereas miR-10b-5p was downregulated in T compared with PT and control tissues. +transcription factor target 36433652 hsa-mir-182 Colorectal Neoplasms The analysis of the three miRNAs targeting IL1B, CXCL8, IL1A, and CSF2 showed that miR5p was upregulated in T compared with PT, whereas miR-10b-5p was downregulated in T compared with PT and control tissues. +circulation_biomarker_diagnosis_ns 36432575 hsa-mir-221 Diabetes Mellitus We aimed to measure the adipose and plasma miR-221 and -222 levels, and to evaluate their association with adiposity, glucose intolerance, and new onset diabetes mellitus (NODM) after the commencement of PD. CONCLUSION: miR-221 and -222 are associated with the progression of obesity, insulin resistance, and NODM after PD. +other 36432575 hsa-mir-221 Insulin Resistance CONCLUSION: miR-221 and -222 are associated with the progression of obesity, insulin resistance, and NODM after PD. +circulation_biomarker_diagnosis_ns 36432575 hsa-mir-221 Obesity Adipose and Plasma microRNAs miR-221 and 222 Associate with Obesity, Insulin BACKGROUND: The correlation between microRNA, obesity, and glycemic intolerance in patients on peritoneal dialysis (PD) is unknown. CONCLUSION: miR-221 and -222 are associated with the progression of obesity, insulin resistance, and NODM after PD. +circulation_biomarker_diagnosis_up 36432399 hsa-mir-103a Diabetes, Gestational The objective of this study is to investigate the relationship of leptin, adiponectin, interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), insulin and HOMA-IRand circulating miRNAs (miR-29a-3p, miR-103a-3p, miR +circulation_biomarker_diagnosis_up 36432399 hsa-mir-222 Diabetes, Gestational The objective of this study is to investigate the relationship of leptin, adiponectin, interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), insulin and HOMA-IRand circulating miRNAs (miR-29a-3p, miR-103a-3p, miR +genetics_GWAS 36431040 hsa-mir-27a Cardiovascular Diseases Methods: Amplification Refractory Mutation System (ARMS) PCR was used to detect MTHFR, KLF-14, miRNA-27a and eNOS3 genotyping in CAD patients and healthy controls. +genetics_GWAS 36431040 hsa-mir-27a Coronary Artery Disease Methods: Amplification Refractory Mutation System (ARMS) PCR was used to detect MTHFR, KLF-14, miRNA-27a and eNOS3 genotyping in CAD patients and healthy controls. +lncRNA target 36430972 hsa-mir-29a Tuberous Sclerosis Of the miRNAs dysregulated before rapamycin treatment in the TSC1 and TSC2 groups, two did not normalize after treatment (miR-33a-3p, miR-29a-3p). +lncRNA target 36430972 hsa-mir-33a Tuberous Sclerosis Of the miRNAs dysregulated before rapamycin treatment in the TSC1 and TSC2 groups, two did not normalize after treatment (miR-33a-3p, miR-29a-3p). +lncRNA target 36430715 hsa-mir-169 Dehydration The improved drought tolerance might be involved in the decreased expression levels of miRNA such as mtr_miR169l-5p, mtr_miR398b, and mtr_miR398c and its target genes in seedlings with active nodules. During severe drought stress, the lncRNA alternative splicings TCONS_00049507 and TCONS_00049510 competitively interacted with mtr_miR169l-5p, which upregulated the expression of NUCLEAR FACTOR-Y (NF-Y) transcription factor subfamily NF-YA genes MtNF-YA2 and MtNF-YA3 to regulate their downstream drought-response genes. +genetics_overexpression_promote 36430501 hsa-mir-408 Neutropenia, Severe Congenital, Autosomal Recessive 4 Overexpressing miR408 could negatively regulate soybean resistance to SCN by suppressing reactive oxygen species accumulation. Conversely, silencing miR408 positively regulates soybean resistance to SCN. +transcription factor target 36430468 hsa-mir-223 Rhabdomyosarcoma Interestingly, IGF1R resulted in the direct target of miR-223 in AYA-RMS cells, as demonstrated by IGF1R silencing. +other 36430249 hsa-mir-369 Inflammatory Bowel Diseases Our data suggest that miR3p may be a future alternative therapeutic approach to several compounds currently used for the treatment of inflammatory disorders including IBD. +lncRNA target 36430219 hsa-mir-592 Neuroblastoma In conclusion, this study develops a lipid-metabolism-related gene-based prognostic model for NB and demonstrates that GDPD5 inhibits SH-SY5Y proliferation and migration and may be targeted by hsa-miR-592 and inhibit SH-SY5Y fat synthesis. +genetics_overexpression_promote 36430152 hsa-mir-515 Glioblastoma TS miRNAs 126-3p and 515-5p were upregulated following circSMARCA5 overexpression in U87MG and their expression was positively correlated with that of circSMARCA5 (r-values = 0.49 and 0.50, p-values = 9 x 10(-5) and 7 x 10(-5), respectively) in GBM biopsies. +genetics_overexpression_promote 36430152 hsa-mir-126 Glioblastoma TS miRNAs 126-3p and 515-5p were upregulated following circSMARCA5 overexpression in U87MG and their expression was positively correlated with that of circSMARCA5 (r-values = 0.49 and 0.50, p-values = 9 x 10(-5) and 7 x 10(-5), respectively) in GBM biopsies. +circulation_biomarker_diagnosis_ns 36428932 hsa-mir-6851 Osteoporosis Conclusions: Bone-metabolism-related serum miRNAs, such as hsa-miR +circulation_biomarker_diagnosis_ns 36428932 hsa-mir-8068 Osteoporosis Conclusions: Bone-metabolism-related serum miRNAs, such as hsa-miR +circulation_biomarker_diagnosis_ns 36428932 hsa-mir-506 Osteoporosis Conclusions: Bone-metabolism-related serum miRNAs, such as hsa-miR +circulation_biomarker_diagnosis_ns 36428932 hsa-mir-144 Osteoporosis Conclusions: Bone-metabolism-related serum miRNAs, such as hsa-miR +other 36428476 hsa-mir-26a Osteoarthritis, Knee 5p were detectable only in a few samples. +other 36428476 hsa-mir-186 Osteoarthritis, Knee 5p were detectable only in a few samples. +other 36428476 hsa-mir-210 Osteoarthritis, Knee 5p were detectable only in a few samples. +other 36428476 hsa-mir-205 Osteoarthritis, Knee 5p were detectable only in a few samples. +other 36428476 hsa-mir-199a Osteoarthritis, Knee 5p were detectable only in a few samples. +transcription factor target 36427803 hsa-mir-615 Carcinoma, Non-Small-Cell Lung In summary, propofol inhibited GPX4-mediated ferroptosis and reduces CR of NSCLC cells to Cis through the miR +transcription factor target 36427803 hsa-mir-744 Carcinoma, Non-Small-Cell Lung In summary, propofol inhibited GPX4-mediated ferroptosis and reduces CR of NSCLC cells to Cis through the miR +epigenetics 36427628 hsa-mir-299 Insulin Resistance 5p-targeted resistin inhibition through demethylation, which underlies the mechanism of reducing IR. +epigenetics 36427628 hsa-mir-299 Myotonic Dystrophy 5p) expression was deficient in T2MD, which could be restored by aerobic exercise through modulating the DNA methylation modification enzymes. +other 36427609 hsa-mir-130b Bone Diseases The predicted circ_CUX1/miR-130b-5p/p300 axis might pave the way for better diagnostic and therapeutic approaches for bone-related diseases. +lncRNA target 36427469 hsa-mir-150 Endometriosis CONCLUSION: MiR5p silencing inhibited hypoxia-induced autophagy and EMT of endometriotic cells by regulating the PDCD4/NF-kappaB signaling pathway. +other 36427432 hsa-mir-141 Pre-Eclampsia Therefore, our data demonstrated that miR3p promoted hypoxia-induced autophagy in placental trophoblast cells, which may be related to the development of preeclampsia. +other 36427432 hsa-mir-141 Pneumonia, Mycoplasma 3p), a multifunctional miRNA, is involved in a variety of physiological and pathological processes, including PE and autophagy. +other 36427432 hsa-mir-141 Hypoxia 3p promoted hypoxia-induced autophagy in placental trophoblast cells, which may be related to the development of preeclampsia. +target gene 36426731 hsa-mir-337 Carcinoma, Non-Small-Cell Lung Circ_0007385 promotes the proliferation and inhibits the apoptosis of non-small cell lung cancer cells via miR-337-3p-dependent regulation of LMO3. +genetics_knock down_promote 36426627 hsa-mir-485 Breast Neoplasms 3p expression weakened the inhibiting effect of circ_0000129 knockdown on BC cell malignant behaviors. +genetics_overexpression_promote 36426595 hsa-mir-146a Depressive Disorder, Major CONCLUSIONS: The findings of this study reveal a relationship between miR-146a-5p overexpression and cortical atrophy and thus may help specify the in vivo mediating effect of miR-146a-5p dysregulation on brain structural abnormalities in patients with MDD. +circulation_biomarker_diagnosis_ns 36426578 hsa-mir-182 Triple Negative Breast Neoplasms Finally, LNPs-miR3p were able to cross the blood-brain barrier and reduce intracranial tumors representing a possible therapeutic option for metastatic brain lesions. +lncRNA target 36426391 hsa-mir-150 Diabetes Mellitus, Type 2 5p and therefore down regulate expression of its target genes involving in immune stimulation and decrease lipid profile including LDL-C, total cholesterol, and ApoB, especially in the group with type 2 diabetes mellitus (T2DM) and COVID-19 compared to the patients with only COVID-19. +lncRNA target 36426391 hsa-mir-150 COVID-19 5p and therefore down regulate expression of its target genes involving in immune stimulation and decrease lipid profile including LDL-C, total cholesterol, and ApoB, especially in the group with type 2 diabetes mellitus (T2DM) and COVID-19 compared to the patients with only COVID-19. +other 36425259 hsa-mir-146a Periodontal Diseases Gingival MSCs were isolated from the gingiva tissues of patients with periodontal disease to reveal the function of miR-146a in regulating osteoblast differentiation. +target gene 36424798 hsa-mir-374a Stomach Neoplasms Gastric cancer derived mesenchymal stem cells promote the migration of gastric cancer cells through miR-374a-5p. +circulation_biomarker_diagnosis_up 36424716 hsa-mir-184 Mucocutaneous Lymph Node Syndrome Kawasaki disease patients were found to have a unique circulating miRNA profile, including upregulation of miRNA +circulation_biomarker_diagnosis_up 36424716 hsa-mir-19a Mucocutaneous Lymph Node Syndrome Kawasaki disease patients were found to have a unique circulating miRNA profile, including upregulation of miRNA +circulation_biomarker_diagnosis_up 36424716 hsa-mir-19a limb ischemia Kawasaki disease patients were found to have a unique circulating miRNA profile, including upregulation of miRNA +circulation_biomarker_diagnosis_up 36424716 hsa-mir-184 limb ischemia Kawasaki disease patients were found to have a unique circulating miRNA profile, including upregulation of miRNA +genetics_knock down_promote 36424704 hsa-mir-202 Carcinoma, Endometrioid 5p depletion or CTNND1 overexpression, respectively. +exosome 36424471 hsa-mir-1228 Carcinoma, Hepatocellular All in all, CAF-EV-carried miR +lncRNA target 36424455 hsa-mir-122 Acute Liver Injury This study identifies a novel lncRNA with protective effects in acute liver injury and demonstrates that the binding of Mir122hg-C/EBPalpha promotes hepatocyte proliferation via upregulation of CXC chemokine and activation of AKT signaling. +exosome 36423858 hsa-mir-100 Endometriosis Collectively, hUC-MSC-EV-loaded miR-100 downregulated HS3ST2 to facilitate the development of endometriosis, which highlights a promising therapeutic target for treating endometriosis. +genetics_overexpression_suppress 36423467 hsa-mir-203a Elliptocytosis 2 These results suggest that miR-203a inhibition and miR-34b overexpression contribute to neurological, cardiovascular and eye toxicity responses that are caused by oil and PAH exposure in ELS fish, and are likely mediated through both AhR and non-AhR pathways. +genetics_overexpression_suppress 36423467 hsa-mir-34b Elliptocytosis 2 These results suggest that miR-203a inhibition and miR-34b overexpression contribute to neurological, cardiovascular and eye toxicity responses that are caused by oil and PAH exposure in ELS fish, and are likely mediated through both AhR and non-AhR pathways. +transcription factor target 36423467 hsa-mir-203a Abnormalities, Drug-Induced When DEGs of miR-203a inhibitor-injected embryos were compared with BaP-exposed DEGs, alterations in nervous system development and function, and abnormal morphology of the neurosensory retina, eye and nervous tissue were predicted, consistent with both AhR and non-AhR pathways. +circulation_biomarker_diagnosis_ns 36423393 hsa-mir-21 Carcinoma, Non-Small-Cell Lung Significantly, accurate evaluation of miRNA-21 expression levels in cancer cell lines and non-small-cell lung carcinomas (NSCLC) serum samples are successfully achieved using the developed method. +lncRNA target 36423383 hsa-mir-146b Thyroid Neoplasms These findings support that targeting the LINC01311/miR-146b-5p/IMPA2 axis may be a promising approach against TC progression. +exosome 36423379 hsa-mir-24 Non-alcoholic Fatty Liver Disease Collectively, our study demonstrated that MSCs-derived exosomal miR3p had hepaprotective effects through targeting Keap-1 signaling, providing a potential therapeutic value for NAFLD treatment. +lncRNA target 36422738 hsa-mir-1179 Stomach Neoplasms Additionally, microRNA-1179 was found to play a key role in inhibiting the expression of ALDOA in the metabolic pathways of GC cells, which might disrupt the expression of various immune molecules and be detrimental to the prognosis of GC. +circulation_biomarker_diagnosis_up 36422510 hsa-mir-373 Alzheimer Disease METHODS: The expression levels of miR-204 and miR-373 were investigated in neuron-derived serum exosomes obtained from 15 patients with mild AD, 18 with moderate AD, and 21 cognitively healthy individuals. +circulation_biomarker_diagnosis_up 36422507 hsa-mir-33a Liver Diseases It was aimed to evaluate the predictive role of circulating miR-33a and mir-200c on high fructose corn syrup (HFCS)-induced fatty liver and vitamin D3 supplementation-related hepatic changes. DISCUSSION: Our current experimental fatty liver study showed that, in a specified dose, vitamin D3 supplementation could alleviate adverse undesirable hepatic effects of HFCS via miR-33a and mir-200c. +circulation_biomarker_diagnosis_up 36422507 hsa-mir-33a Fatty Liver It was aimed to evaluate the predictive role of circulating miR-33a and mir-200c on high fructose corn syrup (HFCS)-induced fatty liver and vitamin D3 supplementation-related hepatic changes. DISCUSSION: Our current experimental fatty liver study showed that, in a specified dose, vitamin D3 supplementation could alleviate adverse undesirable hepatic effects of HFCS via miR-33a and mir-200c. +circulation_biomarker_diagnosis_up 36422507 hsa-mir-200c Liver Diseases It was aimed to evaluate the predictive role of circulating miR-33a and mir-200c on high fructose corn syrup (HFCS)-induced fatty liver and vitamin D3 supplementation-related hepatic changes. DISCUSSION: Our current experimental fatty liver study showed that, in a specified dose, vitamin D3 supplementation could alleviate adverse undesirable hepatic effects of HFCS via miR-33a and mir-200c. +circulation_biomarker_diagnosis_up 36422507 hsa-mir-200c Fatty Liver It was aimed to evaluate the predictive role of circulating miR-33a and mir-200c on high fructose corn syrup (HFCS)-induced fatty liver and vitamin D3 supplementation-related hepatic changes. DISCUSSION: Our current experimental fatty liver study showed that, in a specified dose, vitamin D3 supplementation could alleviate adverse undesirable hepatic effects of HFCS via miR-33a and mir-200c. +other 36421832 hsa-mir-1246 Pleural Effusion, Malignant miRNA-1246 demonstrated 4-fold increased expression (OR: 3.87, 95% CI: 0.43, 35) in the MPE vs. +other 36421832 hsa-mir-150 Pleural Effusion, Malignant HF-PE group and miR5p and miR-1246 in the BA-MPE vs. +other 36421385 hsa-mir-10a Teratozoospermia 3p) did not significantly differ between the study and control groups. +genetics_knock down_promote 36420764 hsa-mir-1245b Uterine Cervical Neoplasms AATBC showed a significant prognostic value and miR-1245b-5p was found to mediate the tumor inhibitory effect of AATBC knockdown, which is speculated to be the underlying molecular mechanism of AATBC in cervical cancer development. +lncRNA target 36420706 hsa-mir-497 Breast Neoplasms 5p could improve the treatment response to paclitaxel in patients with breast cancer by inhibiting MALAT1 and SHOC2. +other 36420648 hsa-mir-146a Arthritis, Rheumatoid This study successfully predicted that LCK, FOXC1 and hsa-miR-146a-5p can be used as potential immune effector molecules of RA. +other 36420078 hsa-mir-455 Lung Neoplasms LINC01635, a long non-coding RNA with a cancer/testis expression pattern, promotes lung cancer progression by sponging miR-455-5p. +circulation_biomarker_diagnosis_up 36419391 hsa-mir-367 Carcinoma, Non-Small-Cell Lung 3p in cancer tissues of 22 NSCLC patients was lower than corresponding normal tissues (P<0.05), and the serum miR +other 36419192 hsa-mir-342 Colitis, Ulcerative 3p-IRAK3 axes were found as potential regulatory pathways in UC. +other 36419192 hsa-mir-650 Colitis, Ulcerative 3p-IRAK3 axes were found as potential regulatory pathways in UC. +circulation_biomarker_diagnosis_ns 36418932 hsa-mir-124 Lupus Nephritis RESULTS: HOXA11-OS was highly expressed in LN tissues, serum, and cells, and the expression of some key autophagy factors and Cyr61 was significantly increased, while miR +lncRNA target 36418889 hsa-mir-203 Ataxia Neuropathy Spectrum Consequently, TBX1 activates the expression of both miR-200 and stemness-inhibitor miR-203 to inhibit their common targets, BMI1 and ZEB2. +lncRNA target 36418889 hsa-mir-200 Cleft Palate Thus, targeting of the ZEB2-miR-200 axis by TBX1 may have potential therapeutic implications in miRassociated tumors and cleft palate. +lncRNA target 36418889 hsa-mir-200 Ataxia Neuropathy Spectrum Consequently, TBX1 activates the expression of both miR-200 and stemness-inhibitor miR-203 to inhibit their common targets, BMI1 and ZEB2. +lncRNA target 36418889 hsa-mir-200b Ataxia Neuropathy Spectrum TBX1 rescues ZEB2-dependent transcriptional inhibition of the miR-200b/200a/429 cluster, whose promoter region contains conserved overlapping cis-regulatory motifs of the ZEB-binding E-box and TBX-binding element. +transcription factor target 36418472 hsa-mir-199 Melanoma, Experimental 5p, inhibit tumor growth both in vitro and in vivo in combination with target therapy and block the development of drug resistance. +transcription factor target 36418472 hsa-mir-204 Melanoma, Experimental 5p, inhibit tumor growth both in vitro and in vivo in combination with target therapy and block the development of drug resistance. +lncRNA target 36418471 hsa-mir-1231 Colorectal Neoplasms Mechanistically, circTDRD3 promoted HIF1alpha expression by sponging miR-1231, which facilitated CRC progression. Our findings reveal that circTDRD3 facilitates the proliferation and metastasis of CRC through a positive feedback loop mediated by the HIF1alpha/PTBP1/circTDRD3/miR-1231/HIF1alpha axis. +circulation_biomarker_diagnosis_ns 36418345 hsa-mir-23b Breast Neoplasms Utilizing multiple bioinformatics tools, six serum-based miRNA biomarkers (miR-92a-3p, miR-23b-3p, miR +circulation_biomarker_diagnosis_ns 36418345 hsa-mir-191 Breast Neoplasms Utilizing multiple bioinformatics tools, six serum-based miRNA biomarkers (miR-92a-3p, miR-23b-3p, miR +circulation_biomarker_diagnosis_ns 36418345 hsa-mir-92a Breast Neoplasms Utilizing multiple bioinformatics tools, six serum-based miRNA biomarkers (miR-92a-3p, miR-23b-3p, miR +lncRNA target 36417821 hsa-mir-217 Acute Lung Injury CONCLUSION: CircWDR33 protected against LPS-induced inflammatory and apoptotic injury, permeability enhancement and tubule formation arrest in HPMECs via miR +lncRNA target 36417821 hsa-mir-217 Sepsis CONCLUSION: CircWDR33 protected against LPS-induced inflammatory and apoptotic injury, permeability enhancement and tubule formation arrest in HPMECs via miR +genetics_knock down_suppress 36417034 hsa-mir-214 Atrial Fibrillation In conclusions, circCAMTA1 knockdown alleviated atrial fibrosis through downregulating TGFBR1 expression intermediated by miR +genetics_knock down_promote 36416408 hsa-mir-1225 Carcinoma, Non-Small-Cell Lung 5p recuperated the effects of circ_0075048 knockdown on NSCLC progression. +genetics_overexpression_promote 36416387 hsa-mir-23a Pancreatic Carcinoma HK-2 overexpression exerted oncogenic effects on pancreatic cancer cells and promoted cellular glycolysis; more importantly, HK-2 overexpression partially eliminated the effects of miR-323a overexpression. +other 36415802 hsa-mir-129 Myocardial Reperfusion Injury 5p. +circulation_biomarker_diagnosis_ns 36415626 hsa-mir-373 Breast Neoplasms the expression level of exosomal miR-21, miR-155, miR-182, and miR-373 in the serum of breast cancer patients was higher than of those controls (P<0.05) +circulation_biomarker_diagnosis_ns 36415626 hsa-mir-21 Breast Neoplasms the expression level of exosomal miR-21, miR-155, miR-182, and miR-373 in the serum of breast cancer patients was higher than of those controls (P<0.05) +circulation_biomarker_diagnosis_ns 36415626 hsa-mir-155 Breast Neoplasms the expression level of exosomal miR-21, miR-155, miR-182, and miR-373 in the serum of breast cancer patients was higher than of those controls (P<0.05) +genetics_knock down_promote 36415199 hsa-mir-181a Osteosarcoma However, knockdown miR-181a-5p promoted the proliferation and migration of osteosarcoma HOS cells, the cells in S phase increased(P<0.05). +lncRNA target 36414916 hsa-let-7c Glioma However, whether RGS16 can promote the progression of glioma and whether it is regulated by miR let-7c-5p are still unknown. Thus, we suggest that the suppression of RGS16 by miR let-7c-5p can promote glioma progression and may serve as a potential prognostic biomarker and therapeutic target in glioma. +other 36414911 hsa-mir-204 Depression Notably, pre-ECT miR-204 levels moderately positively correlated with depression severity at baseline and moderately negatively correlated with mood score reduction post-ECT. +circulation_biomarker_diagnosis_ns 36414650 hsa-mir-144 COVID-19 Plasma microRNA profiling of hospitalized COVID-19 patients showed that miR +other 36414609 hsa-mir-25 Hypertension 3p expression could aid HDIP diagnosis, and associated with an increased risk of adverse pregnancy outcomes in PE patients. +other 36414112 hsa-mir-34 Neurotic Disorders RESULTS: ELA not just induces a depressive-like state as well as enduring changes in miR-34a expression, but also alters miR-34a expression in response to adult acute stress exclusively in females. CONCLUSIONS: This is the first evidence showing long-lasting sex related effects of ELA on brain and peripheral miR-34a expression levels in an animal model of depression-like phenotype. +other 36414112 hsa-mir-34a Neurotic Disorders RESULTS: ELA not just induces a depressive-like state as well as enduring changes in miR-34a expression, but also alters miR-34a expression in response to adult acute stress exclusively in females. CONCLUSIONS: This is the first evidence showing long-lasting sex related effects of ELA on brain and peripheral miR-34a expression levels in an animal model of depression-like phenotype. +transcription factor target 36414029 hsa-mir-122 Myocardial Infarction The current study aims to investigate the cardioprotective effects of xanthenone through targeting the miR-122/Sirt-6/ACE2 axis on experimentally-induced MI in rats. Finally, by targeting the miR-122/Sirt-6/AMPK/ACE2 axis, xanthenone has the potential to be a promising cardioprotective agent against MI. +other 36413508 hsa-mir-24 Aortic Aneurysm, Abdominal This study shows for the first time that inhaled e-cig nicotine vapor augments experimental AAA and aortic inflammation, suggests a mechanistic role for the cytokine Chil1/CHI3L1 and its regulator microRNA-24, and raises red flags regarding longitudinal e-cig safety. +transcription factor target 36413378 hsa-mir-382 Osteoarthritis Our findings revealed that EVs produced by the OA rats contained miR5p, which might reduce cell viability and proliferation, and promote cell apoptosis by targeting PTEN. +circRNA target 36413177 hsa-mir-940 Keloid CONCLUSIONS: This study suggests that hsa_circ_0038382 attenuates keloid formation by regulating the miR-940/TBX5 axis, which might provide a potential therapeutic target in the treatment of keloid formation. +genetics_knock down_promote 36412985 hsa-mir-133b Esophageal Squamous Cell Carcinoma NCK1-AS1 knockdown or miR-133b overexpression inhibited the malignant properties of ESCC cells as well as tumorigenesis in vivo. +circulation_biomarker_diagnosis_ns 36412588 hsa-mir-21 Breast Neoplasms With the proposed method, the expression of miR-21 in different cancer cells can be assessed, and breast cancer patients and healthy individuals can be differentiated by analyzing the target miRNAs extracted from serum samples, holding great potential in clinical diagnosis. +transcription factor target 36412002 hsa-mir-21 Adenocarcinoma of Lung QTPlus-AM21 demonstrates a superior miRdependent gene regulation and eventually inhibits A549 non-small cell lung cancer growth in vitro. +transcription factor target 36412002 hsa-mir-21 Carcinoma, Non-Small-Cell Lung QTPlus-AM21 demonstrates a superior miRdependent gene regulation and eventually inhibits A549 non-small cell lung cancer growth in vitro. +circulation_biomarker_diagnosis_ns 36411886 hsa-mir-122 Carcinoma, Hepatocellular Therefore, significantly elevated levels of miR-122 in plasma exosomes of hepatocellular carcinoma patients could enhance their sensitivity to metformin. +circulation_biomarker_diagnosis_ns 36411886 hsa-mir-122 Diabetes Mellitus, Type 2 Therefore, significantly elevated levels of miR-122 in plasma exosomes of hepatocellular carcinoma patients could enhance their sensitivity to metformin. +genetics_GWAS 36411728 hsa-mir-124-1 Zika virus congenital syndrome We identified that individuals with CZS presented a higher frequency of CG genotype of rs531564 polymorphism in MIR +genetics_GWAS 36411728 hsa-mir-124 Zika virus congenital syndrome We identified that individuals with CZS presented a higher frequency of CG genotype of rs531564 polymorphism in MIR +other 36411682 hsa-mir-145 Acute Kidney Injury mediated autophagy. +other 36411682 hsa-mir-145 Reperfusion Injury mediated autophagy. +lncRNA target 36411681 hsa-mir-200b Liver Neoplasms CONCLUSIONS: MiR-200b is involved in hepatocellular carcinoma progression via targeting SMYD2 and regulating SMYD2/p53/CyclinE1 signaling pathway and may be used as a potential target for hepatocellular carcinoma treatment. +other 36411517 hsa-mir-338 Prostatic Neoplasms has_circ_0070512 promotes prostate cancer progression by regulating the miR-338-3p/hedgehog signaling pathway. +genetics_GWAS 36411451 hsa-mir-218 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Epigenetically, the expression of the SLIT2-embedded non-coding genes SLIT2-IT1 and miR-218 expression was decreased in patients with CML. Furthermore, SLIT2 promoter methylation may function by regulating the expression of the SLIT2-embedded non-coding genes SLIT2-IT1 and miR-218 during CML progression. +transcription factor target 36410437 hsa-mir-150 Prostatic Neoplasms Additionally, profiling of MYB-targeted miRNAs demonstrated significant induction of miR-150 in high-dose androgen-treated PCa cells. Furthermore, MYB-silencing or miR-150 mimic transfection suppressed PCa cell growth induced by low-dose androgen, whereas miR-150 inhibition rescued PCa cells from growth repression by high-dose androgen. +other 36410410 hsa-mir-20b Schizophrenia SIGNIFICANCE: The significant SCZ-related ceRNAs subnetworks (lncRNA-C2orf48A/hsa-miR-20b-5p,5p/KIF23, FOXJ2) may represent promising predictive and diagnostic biomarkers and provide novel insights into the mechanism by which lncRNAs act as microRNA sponges and contribute to the pathogenesis of SCZ. +lncRNA target 36410171 hsa-mir-365a Colorectal Neoplasms RESULTS: In clinical samples and CRC cells, the abundance of HCG18 was enhanced whereas miR-365a-3p was reduced. CONCLUSION: Our results revealed that HCG18 promoted M2 macrophage polarization to facilitate CET resistance to CRC cells through modulating miR-365a-3p/FOXO1/CSF-1 axis. +other 36410106 hsa-mir-516b Glioblastoma Therefore, we aimed to assess the effect of the miRNAs hsa-miR-516a-5p and miRNA hsa-miR-516b-5p on the Glioblastoma cell line (T98G). +other 36410106 hsa-mir-516a Glioblastoma Therefore, we aimed to assess the effect of the miRNAs hsa-miR-516a-5p and miRNA hsa-miR-516b-5p on the Glioblastoma cell line (T98G). +transcription factor target 36410068 hsa-mir-375 Fatty Liver This study uniquely revealed that miR-375 induced lipid synthesis and inhibited cell proliferation may partly due to regulation of RBPJ expression, thereby involving in fatty liver formation and inheritance in chicken. +circRNA target 36409529 hsa-mir-188 Pneumonia, Mycoplasma 3p, thereby inhibiting trophoblast cells function, which suggested a new molecular mechanism for the pathogenesis of PE. +exosome 36409397 hsa-mir-1 Adenocarcinoma of Lung CONCLUSIONS: The promoting effect of IH on LUAD is achieved partly through BMSCs-derived exosomal miR +other 36408612 hsa-mir-454 Osteoporosis 5p were defined as top biomarker candidates with the strongest association to the sustained effect of denosumab on bone in osteoporotic patients. +other 36408612 hsa-mir-26b Osteoporosis 5p were defined as top biomarker candidates with the strongest association to the sustained effect of denosumab on bone in osteoporotic patients. +other 36408612 hsa-mir-584 Osteoporosis 5p were defined as top biomarker candidates with the strongest association to the sustained effect of denosumab on bone in osteoporotic patients. +lncRNA target 36408278 hsa-mir-155 Neurogenic Inflammation Thus, BA suppressed the LPS-stimulated neuroinflammation in BV-2 microglia by blocking the TLR4-mediated signal transduction through TLR4/MyD88/NF-kappaB and MAPK pathways and inhibiting the miR-155 expression. +lncRNA target 36407085 hsa-mir-135b Colonic Neoplasms Moreover, the effects of hsa-miR-135b-5p on the biological behavior of COAD cells were observed. Therefore, downregulation of hsa-miR-135b-5p inhibits cell proliferation, migration, and invasion in COAD, and carcinogenesis may function by targeting FOXN2, NSA2, MYCBP, DIRAS2, DESI1, and RAB33B. +circulation_biomarker_diagnosis_ns 36406766 hsa-mir-182 Schizophrenia On the other hand, inhibition of the miR-182/183 cluster ameliorated SZ, as evidenced by elevated serum levels of NGF and BDNF, along with reductions in spontaneous activity, serum GFAP levels, and hippocampal neuronal apoptosis. +circulation_biomarker_diagnosis_ns 36406766 hsa-mir-183 Schizophrenia On the other hand, inhibition of the miR-182/183 cluster ameliorated SZ, as evidenced by elevated serum levels of NGF and BDNF, along with reductions in spontaneous activity, serum GFAP levels, and hippocampal neuronal apoptosis. +lncRNA target 36406317 hsa-mir-203a Carcinoma, Hepatocellular RESULTS: MiR-203a was significantly down-regulated in HBsAg-positive HCC with the sharpest decrease shown in microarray analysis. miR-203a may serve as a crucial treatment target in HBsAg-positive HCC. +lncRNA target 36406123 hsa-mir-190a Ovarian Failure, Premature In conclusion, miRNA-190a-5p may become a potential biomarker for early screening of POF, and it can continuously activate primordial follicles in rats by targeting the expression of PHLPP1 and key proteins in the AKT-FOXO3a and AKT-LH/LHR pathways. +other 36406123 hsa-mir-151 Ovarian Failure, Premature 5p. +other 36406123 hsa-mir-27b Ovarian Failure, Premature 5p. +other 36405735 hsa-mir-663a Stomach Neoplasms An ELNs-related signature model based on ELNs group, regulatory T cells (Tregs), neutrophils, CDKN2B-AS1, H19, HOTTIP, LINC00643, MIR663AHG, TMEM236, ZNF705A, and hsa-miR-135a-5p was constructed by the LASSO-Cox regression analysis. +other 36405735 hsa-mir-135a Stomach Neoplasms An ELNs-related signature model based on ELNs group, regulatory T cells (Tregs), neutrophils, CDKN2B-AS1, H19, HOTTIP, LINC00643, MIR663AHG, TMEM236, ZNF705A, and hsa-miR-135a-5p was constructed by the LASSO-Cox regression analysis. +transcription factor target 36405246 hsa-mir-524 Colonic Neoplasms 5p/CXCR7 axis regulated angiogenesis in colon cancer cells through the AKT and ERK pathways. +circulation_biomarker_diagnosis_down 36404826 hsa-mir-20a Diabetes Mellitus, Type 2 METHODS: In the present study, we checked the expression of miR-320a, 182-5p, 503, and 375 by using quantitative PCR in both stimulated and unstimulated saliva and blood samples of 40 adult patients with type-2 diabetes compared to 40 healthy individuals. +genetics_knock down_promote 36404720 hsa-mir-885 Prostatic Neoplasms 5p, thereby blocking the effect of HOXA-AS2 knockdown by the miR +lncRNA target 36403772 hsa-mir-222 Prostatic Hyperplasia Our findings elucidate that the pseudogene/lncRNA-hsa-miR3p-XBP1 pathway may play a regulatory role in the occurrence of BPH through autophagy. +lncRNA target 36403324 hsa-mir-29a Tendon Injuries Here, microRNA29a is identified as a promising therapeutic target for tendon injury through the cross-regulation of the immune response and matrix remodeling. In vivo studies of the Achilles tendon-rupture model indicate the best repair in the miR29a group, as evidenced by superior collagen composition and alignment, higher mechanical strength, and better functional recovery. +genetics_overexpression_suppress 36403222 hsa-mir-205 Influenza, Human 5p overexpression-induced inhibition of influenza A replication could be attributed to the inhibition of NP expression. +circRNA target 36403044 hsa-mir-27a Hypertension, Pulmonary CONCLUSION: Our findings demonstrated that circGSAP alleviated the dysfunction of PMECs via the increase of BMPR2 by competitively binding with miR-27a-3p, and mitigated pulmonary vascular remodeling of MCT-PH rats, providing potential therapeutic strategies for IPAH. +other 36401723 hsa-mir-217 Uterine Cervical Neoplasms As a consequence, the intention of this study is to look at the relationship among the synthesis of miRNAs (miR 217 and miR3p), which can be utilized as molecular biomarkers to predict pathological responses in cervical cancer patients after radiation and chemotherapy. +other 36401723 hsa-mir-140 Uterine Cervical Neoplasms As a consequence, the intention of this study is to look at the relationship among the synthesis of miRNAs (miR 217 and miR3p), which can be utilized as molecular biomarkers to predict pathological responses in cervical cancer patients after radiation and chemotherapy. +exosome 36401721 hsa-mir-506 Colorectal Neoplasms The goal of the research was to study into the role of exosomal-miR +transcription factor target 36401720 hsa-mir-144 Necrobiotic Disorders Furthermore, the inhibition of miR5p reduced the cell viability, increased cell apoptosis, and enhanced fibrosis and pyroptosis of H9C2 cells after H/R or H/R PostC treatment. +transcription factor target 36401720 hsa-mir-144 Fibrosis Furthermore, the inhibition of miR5p reduced the cell viability, increased cell apoptosis, and enhanced fibrosis and pyroptosis of H9C2 cells after H/R or H/R PostC treatment. +other 36401685 hsa-mir-34a Osteosarcoma LncRNA HCG18 Promotes Osteosarcoma Cells Proliferation, Migration, and Invasion in by Regulating miR-34a/RUNX2 Pathway. +other 36401491 hsa-mir-144 Urologic Neoplasms Low miR-144 expression had better predictive value in patients with urinary system cancer (HR: 0.48, 95% CI: 0.35-0.64). +other 36401446 hsa-mir-34a Pulmonary Disease, Chronic Obstructive In conclusion, Res attenuated CSE-induced cellular senescence in BEAS-2B cells by regulating the miR-34a/SIRT1/NF-kappaB pathway, which may provide a new approach for COPD treatment. +genetics_GWAS 36401419 hsa-mir-146a Coronary Disease MicroRNA (miRNA)-146a rs2910164, a single nucleotide polymorphism, is associated with the progression of CHD risk. +lncRNA target 36401368 hsa-mir-200c Breast Neoplasms Collectively, baicalin significantly suppresses cell viability, migration, and invasion of BC cells possibly by regulating the TGF-beta/lncRNA-MALAT1/miR-200c pathway. +genetics_overexpression_promote 36401052 hsa-mir-421 Parkinson Disease Overexpressed SNHG8 downregulates miR +lncRNA target 36400758 hsa-mir-202 Cholangiocarcinoma Mechanistically, linc00976 competitively interacted with miR-3202 to upregulate GPX4 expression, thus contributing to the malignant biological behavior of CCA cells. Accordingly, JUND promotes linc00976 transcription, and linc00976 plays a crucial role in accelerating CCA tumorigenesis and metastasis and inhibiting ferroptosis by modulating the miR-3202/GPX4 axis. +circulation_biomarker_diagnosis_up 36400592 hsa-mir-155 Neoplasm, Residual "RESULTS: The relative expression of plasma miR-155 (P = .0003), miR-223 (P = .0316), and miR-21 (P = .0147) were significantly higher in patients who had subsequent histology-approved ABMR with donor-specific anti-HLA antibody positivity (n = 10) than in the ""triple negative"" group (n = 21), and miR-155 showed the highest sensitivity (90%) and specificity (81%) to indicate ABMR development based on receiver operating characteristic analysis. CONCLUSIONS: According to our preliminary data, plasma miR-155, miR-21, and miR-223 can indicate the development of ABMR after kidney transplant in correlation with classic clinical parameters." +circulation_biomarker_diagnosis_up 36400592 hsa-mir-21 Neoplasm, Residual "RESULTS: The relative expression of plasma miR-155 (P = .0003), miR-223 (P = .0316), and miR-21 (P = .0147) were significantly higher in patients who had subsequent histology-approved ABMR with donor-specific anti-HLA antibody positivity (n = 10) than in the ""triple negative"" group (n = 21), and miR-155 showed the highest sensitivity (90%) and specificity (81%) to indicate ABMR development based on receiver operating characteristic analysis. CONCLUSIONS: According to our preliminary data, plasma miR-155, miR-21, and miR-223 can indicate the development of ABMR after kidney transplant in correlation with classic clinical parameters." +circulation_biomarker_diagnosis_up 36400592 hsa-mir-223 Neoplasm, Residual "RESULTS: The relative expression of plasma miR-155 (P = .0003), miR-223 (P = .0316), and miR-21 (P = .0147) were significantly higher in patients who had subsequent histology-approved ABMR with donor-specific anti-HLA antibody positivity (n = 10) than in the ""triple negative"" group (n = 21), and miR-155 showed the highest sensitivity (90%) and specificity (81%) to indicate ABMR development based on receiver operating characteristic analysis. CONCLUSIONS: According to our preliminary data, plasma miR-155, miR-21, and miR-223 can indicate the development of ABMR after kidney transplant in correlation with classic clinical parameters." +lncRNA target 36399797 hsa-mir-485 Carcinoma, Ovarian Epithelial CONCLUSION: SNHG17 silencing inhibits the development of EOC via regulation of miR +lncRNA target 36399659 hsa-mir-16b Staphylococcal Infections aureus-induced inflammation via microRNA-16b/YAP1-mediated regulation, and these findings might provide a new strategy for the prevention of bovine mastitis, facilitating further studies good of zoonotic diseases caused by S. +genetics_overexpression_promote 36399467 hsa-mir-34a Melanoma CONCLUSION: Melanoma cells overexpressed KCNQ1OT1, which influenced the miR-34a/STAT3 axis, to promote proliferation, migration, and invasion of melanoma cells. +transcription factor target 36399285 hsa-mir-106b Leukemia, Myeloid We also showed that inhibitors of the miR-106b-25 cluster and BCL-2 exert synergistic effects on apoptosis induction in primary myeloid leukaemic cells. Thus, the members of the miR-106b-25 cluster may jointly contribute to myeloid leukaemia drug resistance by inactivating multiple apoptotic genes. +other 36398728 hsa-mir-193a Stomach Neoplasms LINC00152 down-regulated miR-193a-3p to enhance MCL1 expression and promote gastric cancer cells proliferation. +other 36398319 hsa-mir-15b Neoplasm, Residual Among them, expression levels of microRNA-15b, microRNA-106a, and microRNA-374a gradually decreased with the severity of ABMR lesions. +other 36398319 hsa-mir-374a Neoplasm, Residual Among them, expression levels of microRNA-15b, microRNA-106a, and microRNA-374a gradually decreased with the severity of ABMR lesions. +other 36398319 hsa-mir-106a Neoplasm, Residual Among them, expression levels of microRNA-15b, microRNA-106a, and microRNA-374a gradually decreased with the severity of ABMR lesions. +exosome 36398229 hsa-mir-665 Osteosarcoma CONCLUSION: This work proved that exosomes loaded with miR-665 inhibited the progression of OS in vivo and in vitro in a safe manner. +exosome 36398226 hsa-mir-382 Sepsis CONCLUSION: EPC-derived exosomal miR +other 36398070 hsa-mir-200b Pterygium The pterygium-associated circRNA-miRNA-mRNA network was established based on the top 10 DE-circRNAs, 4 validated miRNAs (upregulated miR-376a-5p and miR-208a-5p,downregulated miR-203a-3p and miR-200b-3p), and 31 DE-mRNAs. +other 36398070 hsa-mir-1 Pterygium We found that hsa_circ_0002406 might upregulate FN1 and ADAM12 by sponging miR-26b-5p and miR3p, respectively, thus promoting EMT in pterygium. +other 36398070 hsa-mir-203a Pterygium The pterygium-associated circRNA-miRNA-mRNA network was established based on the top 10 DE-circRNAs, 4 validated miRNAs (upregulated miR-376a-5p and miR-208a-5p,downregulated miR-203a-3p and miR-200b-3p), and 31 DE-mRNAs. +other 36398067 hsa-mir-148a Carcinoma, Hepatocellular In general, our data provided evidence that HCG18/hsa-mir-148a-regulated high expression of LAYN is associated with immune cell infiltration and unfavorable prognosis of LIHC patients. +lncRNA target 36397699 hsa-mir-361 Hyalinosis, Systemic CONCLUSION: The circRNA-ZNF638 contributes the proper induced activation of SHF-stem cells in cashmere goats in m6A-dependent manner through miR +lncRNA target 36397308 hsa-mir-1272 Colorectal Neoplasms CONCLUSION: Circ_0006508-mediated miR-1272 inhibition could promote the malignant behaviors of colorectal cancer with an upregulated Warburg effect. +other 36397164 hsa-mir-1208 Glioblastoma The following rescue experiments demonstrated that circPTPRF was a miR-1208 sponge for upregulating YY1 expression to promote proliferation, invasion and neurosphere formation abilities of GBM in vitro. In conclusion, the circPTPRF/miR-1208/YY1 axis can regulate GBM progression. +transcription factor target 36396820 hsa-mir-361 Colorectal Neoplasms nucleatum-infected CRC via the MYC/miR5p/sonic hedgehog pathway cascade, subsequently reversing stemness and abolishing F. +exosome 36396777 hsa-mir-376c Osteoarthritis Meanwhile, the in vivo experiments also corroborated that the miR-376c-3p in hADSC-derived Exos mitigated OA-induced chondrocyte degradation and synovial fibrosis. MiR-376c-3p in hADSC-derived Exos repressed the WNT-beta-catenin pathway by targeting WNT3 or WNT9a, and then mitigating OA-induced chondrocyte degradation and synovial fibrosis, thereby providing theoretical basis for clinical implementation of treatment. +genetics_knock down_promote 36396668 hsa-mir-548l Neuroblastoma We also found that miR-548l overexpression suppressed cell viability and promoted apoptosis, while miR-548l knockdown promoted cell viability and inhibited apoptosis in neuroblastoma cells. +transcription factor target 36396627 hsa-mir-760 Urinary Bladder Neoplasms Together, we concluded a regulatory axis composed of METTL1/m(7)G/miR-760/ATF3 in regulating BCa progression and provided potential therapeutic targets for BCa. +exosome 36396626 hsa-mir-769 Oculodigitoesophagoduodenal syndrome 5p to be loaded into extracellular vesicles (EVs) and to promote MMT reversal in recipient mesenchymal-like MCs. +other 36396626 hsa-mir-769 Fibrosis In conclusion, we highlighted an HDAC1-WT1-miR5p axis potentially relevant for therapies aimed at counteracting organ fibrosis. +genetics_knock down_promote 36396591 hsa-mir-1297 salivary gland adenoid cystic carcinoma STUDY DESIGN: The expression of long non-coding RNA human leukocyte antigen complex group 11 (HCG11), microRNA-1297 (miR-1297), and EphA2 in SACC cell lines compared with normal human salivary gland (HSG) cell line was measured by reverse transcription-quantitative polymerase chain reaction. +other 36396240 hsa-mir-141 Prostatic Neoplasms The latest research shows that the expression level of microRNA-141 can predict the number of prostate cancer cells in the human body and has become an important biomarker. In this paper, an all-carbon sandwich self-powered biosensor based on graphene and carbon cloth is constructed for the highly sensitive detection of the prostate tumor marker miRNA-141. +other 36394782 hsa-mir-1246 Breast Neoplasms MiR-1246 has recently gained much attention and many studies have shown its oncogenic role in colorectal, breast, lung, and ovarian cancers. +genetics_overexpression_promote 36394255 hsa-mir-326 Thyroid Cancer, Papillary Additionally, miR-326 was a downstream target of circ_0003892, and miR-326 overexpression weakened the promoting effect of circ_0003892 overexpression on the malignant progression of PTC. +other 36394070 hsa-mir-148a Sleep Apnea, Obstructive 5p + 1.13 let-7d-3p. +other 36394070 hsa-mir-486 Sleep Apnea, Obstructive 5p + 1.13 let-7d-3p. +other 36394070 hsa-mir-744 Sleep Apnea, Obstructive 5p + 1.13 let-7d-3p. +other 36394065 hsa-mir-142 Adenocarcinoma of Lung 3p expression level was significantly associated with advanced TNM stage in Lung adenocarcinoma patients. +other 36389659 hsa-mir-146 Neurogenic Inflammation Compensatory upregulation of miR-146a can explain the attenuation of the LPS-induced neuroinflammation. Altogether, our results show the existence of crosstalk between miR-146a and mir-146b in the regulation of LPS-induced neuroinflammation. +other 36389659 hsa-mir-146a Neurogenic Inflammation Compensatory upregulation of miR-146a can explain the attenuation of the LPS-induced neuroinflammation. Altogether, our results show the existence of crosstalk between miR-146a and mir-146b in the regulation of LPS-induced neuroinflammation. +genetics_knock down_promote 36389659 hsa-mir-146b Neurogenic Inflammation Our experiments demonstrated that miR-146b deficiency results in the attenuation of LPS-induced neuroinflammation, as it was evidenced by the reduction of sickness behavior, a decrease in the inflammatory status of microglia, and the loss of morphological signs of microglial activation in the hippocampus. +lncRNA target 36389338 hsa-mir-491 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: LncRNA KCNQ1OT1 was associated with the radioresistance of radioresistant LUSC cells, and the lncRNA KCNQ1OT1/miR5p/TPX2-RNF2 axis might be used as a therapeutic target to enhance the radiosensitivity of radioresistant LUSC cells. +transcription factor target 36389185 hsa-mir-29a Tuberculosis, Pulmonary The upregulation of miRNA-29a-3p suppresses the immune response by post-transcriptionally inhibiting interferon (INF)- expression in T cells, increasing susceptibility to pulmonary TB. +tissue_expression_ns 36388982 hsa-mir-17 Thymic aplasia We demonstrate that transgenic miR-17 approximately 92 cell-intrinsically largely overcomes defects caused by CD28 deficiency. +other 36388689 hsa-mir-200b Stomach Neoplasms Interfering HMGB3 release from cancer-associated fibroblasts by miR-200b represses chemoresistance and epithelial-mesenchymal transition of gastric cancer cells. +circulation_biomarker_prognosis_down 36388649 hsa-mir-375 Esophageal Squamous Cell Carcinoma RESULTS: miR-375 expression was significantly downregulated in both ESCC clinical tissues and serum, and the reduction of miR-375 was remarkably linked to a poor prognosis in ESCC. +exosome 36388165 hsa-mir-4455 Glomerulonephritis, IGA This study revealed that MC-derived exosomal miR-4455 is a key factor affecting podocyte injury and provides a series of potential therapeutic targets for treating IgA nephropathy. +target gene 36388045 hsa-mir-137 Carcinoma, Non-Small-Cell Lung miR-137 represses migration and cell motility by targeting COX-2 in non-small cell lung cancer. +other 36387469 hsa-mir-21 Adenocarcinoma of Lung Finally, we discovered that the lncRNA MIR17HG/AC009299.3/miR5p/CCL20 regulatory network might be crucial in the pathogenesis of LUAD. +epigenetics 36387263 hsa-mir-1 Prostatic Neoplasms 3p expression by promoter hypermethylation. +lncRNA target 36387210 hsa-mir-628 Triple Negative Breast Neoplasms This study demonstrated the vital roles of WFDC21P and its m6A in regulating the proliferation and metastasis of TNBC cells via the WFDC21P/miR-628/SMAD3 axis. +target gene 36387162 hsa-mir-134 Melanoma Circ_0084043-miR-134-5p axis regulates PCDH9 to suppress melanoma. +lncRNA target 36387061 hsa-mir-1249 Osteosarcoma CONCLUSIONS: Our study uncovered the cancer-promoting role of LINC00665 in OS, and the feedback loop of LINC00665/miR5p/WNT2B/Wnt might be a potential target for OS treatment. +circulation_biomarker_prognosis_up 36386576 hsa-mir-10a Pneumonia RESULTS: Compared with healthy control, serum miR-10a-3p expression in patients with severe pneumonia was distinctly upregulated (P < 0.001). +other 36385489 hsa-mir-875 Carcinoma, Hepatocellular YY1-activated LINC01608 could promote HCC progression by associating with miR5p to induce the EGFR/ERK signalling pathway. +other 36385302 hsa-mir-218 Alopecia miR-218 has therapeutic potential for alopecia since it can activate the Wnt/beta-catenin channel by down-regulating SFRP2, which is a key channel in hair follicle cycle transformation for hair regrowth. +lncRNA target 36385135 hsa-mir-574 Colorectal Neoplasms Our results suggested that NALT1 promoted CRC proliferation and migration by sponging miRNA5p to upregulate PEG10 expression, and implied that NALT1 might act as a promising biomarker and therapeutic target for CRC. +lncRNA target 36384413 hsa-mir-29c Nerve Degeneration SNHG15 served as a sponge to down-regulate miR-29c-3p, thereby releasing the inhibition of miR-29c-3p on SNCA expression, which promoted neuronal damages upon MPP(+) challenge. CONCLUSION: The upregulation of SNHG15 upon MPP(+) challenge mediates neuronal damages in SK-N-SH cells by regulating miR-29c-3p/SNCA axis. +lncRNA target 36384265 hsa-mir-214 Cardiomyopathies 3p could inhibit LPSinduced myocardial injury by targeting CTSB, which provides a new idea for myocardial damage caused by sepsis. +lncRNA target 36384265 hsa-mir-214 Sepsis 3p could inhibit LPSinduced myocardial injury by targeting CTSB, which provides a new idea for myocardial damage caused by sepsis. +transcription factor target 36384170 hsa-mir-155-1 Distal myopathy, Nonaka type 1 could act as a positive factor for virus replication in DEFs, which inhibited type I interferon (IFN-I) production. +genetics_overexpression_suppress 36384115 hsa-mir-145 Sucrase-isomaltase deficiency, congenital 5p overexpression. +other 36383327 hsa-mir-744 Multiple Sclerosis 5p is recommended as an important biomarker for the development together of diabetes mellitus, Alzheimer's disease, and MS disease. +circRNA target 36382967 hsa-mir-584 Carcinoma, Non-Small-Cell Lung CONCLUSION: Circ_0079530 promoted NSCLC progression by regulating the miR5p/THBS2 axis, providing a possible circRNA-targeted therapy for NSCLC. +lncRNA target 36382488 hsa-mir-137 Glioma CONCLUSIONS: It was found that miR-137 could target E2F7 to restrain cell progression and accelerate programmed cell death of glioma cells, which is helpful to search for new molecular therapeutic targets for glioma. +lncRNA target 36382487 hsa-mir-27b Glioma CONCLUSIONS: Silencing LINC01128 inhibited the proliferation, migration, and invasion levels of glioma cells by targeting miR-27b-3p, thereby affecting the progression of gliomas. +lncRNA target 36381992 hsa-mir-92b Pulmonary Disease, Chronic Obstructive Five miRNAs were significantly dysregulated between exacerbating and stable COPD participants, with miR3p resulting in the highest AUC (0.755, p = 0.006) for a single miRNA, with a combination of three miRNAs (miR-92b-3p, miR-374a-5p and miR-106b-3p) providing the highest discriminatory power (AUC 0.820, p = 0.001). +lncRNA target 36381992 hsa-mir-374b Pulmonary Disease, Chronic Obstructive RESULTS: One miRNA was significantly dysregulated between moderate GOLD participants compared to severe/very severe GOLD participants, with an AUC of 0.798, p = 0.01 for miR-374b-5p. +lncRNA target 36381992 hsa-mir-223 Pulmonary Disease, Chronic Obstructive Five miRNAs were significantly dysregulated between exacerbating and stable COPD participants, with miR3p resulting in the highest AUC (0.755, p = 0.006) for a single miRNA, with a combination of three miRNAs (miR-92b-3p, miR-374a-5p and miR-106b-3p) providing the highest discriminatory power (AUC 0.820, p = 0.001). +lncRNA target 36381992 hsa-mir-374a Pulmonary Disease, Chronic Obstructive Five miRNAs were significantly dysregulated between exacerbating and stable COPD participants, with miR3p resulting in the highest AUC (0.755, p = 0.006) for a single miRNA, with a combination of three miRNAs (miR-92b-3p, miR-374a-5p and miR-106b-3p) providing the highest discriminatory power (AUC 0.820, p = 0.001). +lncRNA target 36381675 hsa-mir-27a Colonic Neoplasms CONCLUSIONS: Quercetin strongly enhanced 5-FU sensitivity via suppression of the miR-27a/Wnt/beta-catenin signalling pathway in CRC, which advocates further research of this combination with the lower dose of 5-FU. +lncRNA target 36381675 hsa-mir-27 Colonic Neoplasms CONCLUSIONS: Quercetin strongly enhanced 5-FU sensitivity via suppression of the miR-27a/Wnt/beta-catenin signalling pathway in CRC, which advocates further research of this combination with the lower dose of 5-FU. +other 36381642 hsa-mir-595 Coronary Artery Disease In CAD patients, decreased expression of miR3p and increased expression of miR-595 may aid the progression of atherosclerotic plaques by regulating CCL3, CCL4, IL-1beta, TNFalphaIP3, and NF-kappaBIalpha gene expression. +other 36381642 hsa-mir-24 Coronary Artery Disease In CAD patients, decreased expression of miR3p and increased expression of miR-595 may aid the progression of atherosclerotic plaques by regulating CCL3, CCL4, IL-1beta, TNFalphaIP3, and NF-kappaBIalpha gene expression. +lncRNA target 36381585 hsa-mir-142a Peripheral Nerve Injuries Together, these results suggest that miR-142a-3p may be a potential target for therapeutic intervention to prevent motor endplate degradation following peripheral nerve injury. +target gene 36381334 hsa-mir-122 Prostatic Neoplasms MicroRNA-122 targets delta-catenin to suppress the tumorigenic potential of prostate cancer cells. +genetics_GWAS 36381329 hsa-mir-99b Breast Neoplasms MiR-99b-high breast cancer was associated with high homologous recombination deficiencies, intratumor heterogeneity, and high rates of mutation and neoantigens. +genetics_GWAS 36381083 hsa-mir-217 Retinoblastoma 3p was significantly related to family genetic history (p 0.0001), optic nerve infiltration (p 0.0001), lymph node metastasis (p=0.0090), and pathological grade (p 0.0001). +genetics_GWAS 36381083 hsa-mir-592 Retinoblastoma 3p was significantly related to family genetic history (p 0.0001), optic nerve infiltration (p 0.0001), lymph node metastasis (p=0.0090), and pathological grade (p 0.0001). +other 36380872 hsa-mir-369 Thyroid Neoplasms lncRNA EGFEM1P promotes thyroid cancer progression by acting as an miR-369-3p sponge and upregulating TCF4. +genetics_knock down_promote 36380666 hsa-mir-38 Nasopharyngeal Carcinoma 3p targeted and negatively regulated ELAVL1; ELAVL1 overexpression affected the effects of miR +lncRNA target 36380665 hsa-mir-21 Colorectal Neoplasms Methods: The colorectal carcinoma (CRC) cell HCT116 was divided into blank control, negative control (NC), si-GAS5 and si-GAS5+ miR-21 inhibitor groups. Conclusion: GAS5 can act as a competing endogenous RNA for miR-21, and down regulation of GAS5 can promote the development of CRC by activating the miR-21/PTEN/Akt signaling pathway and promoting the acquisition of EMT and tumor cell stemness. +other 36380664 hsa-mir-503 Esophageal Squamous Cell Carcinoma The xenograft experiment showed that the subcutaneous tumor in shMIR503HG group was significantly smaller than that in shNC group, and the tumor weight in shMIR503HG group was (0.097+/-0.026) g, which was lower than (0.166+/-0.021) g in shNC group (P<0.001). +circulation_biomarker_diagnosis_ns 36380587 hsa-mir-126 Neoplasms, Vascular Tissue In a validated experimental model of lethal murine vascular neoplasm, tumor-originating EV delivered its miR-126 cargo to tumor-associated macrophages (TAMs). +genetics_overexpression_promote 36380260 hsa-mir-125b Carcinoma, Endometrioid Besides, the promoting impact of MTFP1 overexpression on malignant phenotypes of EC cells could be restored by miR-125b-5p up-regulation. +circRNA target 36380035 hsa-mir-873 Carcinoma, Hepatocellular 5p directly targeted the 3' untranslated region (3'UTR) of PHF2, and PHF2 was negatively regulated by miR +lncRNA target 36379611 hsa-mir-7 Carcinoma, Non-Small-Cell Lung In our previous work, we reported that the targeted expression of microRNA-7 (miR-7) operated by thyroid transcription factor-1 (TTF-1) promoter inhibited the growth of human lung cancer cells in vitro and in vivo; however, the intervention efficiency needed to be further improved. On the whole, our study revealed that the optimized TTF-1 promoter could more effectively operate miR-7 to influence the growth of human NSCLC cells, providing a new basis for the development of microRNA-based targeting gene therapy against clinical lung cancer. +other 36379393 hsa-mir-146a Osteoarthritis Following the two-phase validation process, three miRNAs (miR-23a-3p, miR-146a-5p, and miR3p) were increased in patients with hand OA compared with healthy control subjects and were associated with the AUSCAN sum score and AUSCAN pain. +other 36379393 hsa-mir-23a Osteoarthritis Following the two-phase validation process, three miRNAs (miR-23a-3p, miR-146a-5p, and miR3p) were increased in patients with hand OA compared with healthy control subjects and were associated with the AUSCAN sum score and AUSCAN pain. +other 36379393 hsa-mir-652 Osteoarthritis Following the two-phase validation process, three miRNAs (miR-23a-3p, miR-146a-5p, and miR3p) were increased in patients with hand OA compared with healthy control subjects and were associated with the AUSCAN sum score and AUSCAN pain. +other 36379214 hsa-mir-124 Bipolar Disorder 3p increases GRIA2-lacking calcium-permeable AMPARs and perturbs AMPAR-mediated excitatory synaptic transmission, leading to deficits in the behavioral dimensions shared between SZ and BP. +other 36379214 hsa-mir-124 Schizophrenia 3p increases GRIA2-lacking calcium-permeable AMPARs and perturbs AMPAR-mediated excitatory synaptic transmission, leading to deficits in the behavioral dimensions shared between SZ and BP. +other 36378391 hsa-mir-488 Epilepsy LncRNA PVT1 Promotes Neuronal Cell Apoptosis and Neuroinflammation by Regulating miR-488-3p/FOXD3/SCN2A Axis in Epilepsy. +other 36378340 hsa-mir-1914 Ovarian Neoplasms We hypothesize that mir-1914 might open a new line of research in the realm of managing the recurrence of OC and could be a significant factor in triggering OC recurrence. +genetics_overexpression_promote 36377304 hsa-mir-199b Carcinoma, Hepatocellular Overexpressed miR-199b-3p constrained HCC cell proliferation, migration, and invasion while fostering apoptosis, which could be counteracted by upregulating AURKA. +other 36377220 hsa-mir-503 Endometriosis Poly lactic-co-glycolic-based NPs were used as vector carriers for miRNA 503 transfection in endometriosis cells. +transcription factor target 36377217 hsa-mir-140 Pneumonia CONCLUSION: In ASMCs, miR3p can inhibit the JAK2/STAT3 signaling pathway by targeting HMGB1, thus ameliorating airway inflammation and remodeling in the pathogenesis of asthma. +circulation_biomarker_diagnosis_ns 36377217 hsa-mir-140 Asthma 3p expression was declined in asthmatic patients' plasma and ASMCs stimulated by PDGF-BB. +lncRNA target 36377216 hsa-mir-18a Colorectal Neoplasms CONCLUSION: CASC2 inhibits CRC development by suppressing miR-18a-5p and raising BTG3 expression. +other 36376850 hsa-mir-509 Carcinoma, Hepatocellular 3p, and hsa-miR-193a-5p) accurately predicted postoperative and posttransplantation malignancy recurrence in HCC patients and was also valuable for prognostic evaluation of HCC patients. +other 36376850 hsa-mir-421 Carcinoma, Hepatocellular 3p, and hsa-miR-193a-5p) accurately predicted postoperative and posttransplantation malignancy recurrence in HCC patients and was also valuable for prognostic evaluation of HCC patients. +other 36376850 hsa-mir-769 Carcinoma, Hepatocellular 3p, and hsa-miR-193a-5p) accurately predicted postoperative and posttransplantation malignancy recurrence in HCC patients and was also valuable for prognostic evaluation of HCC patients. +other 36376850 hsa-mir-42 Carcinoma, Hepatocellular 3p, and hsa-miR-193a-5p) accurately predicted postoperative and posttransplantation malignancy recurrence in HCC patients and was also valuable for prognostic evaluation of HCC patients. +other 36376850 hsa-mir-296 Carcinoma, Hepatocellular 3p, and hsa-miR-193a-5p) accurately predicted postoperative and posttransplantation malignancy recurrence in HCC patients and was also valuable for prognostic evaluation of HCC patients. +other 36376850 hsa-mir-193a Carcinoma, Hepatocellular 3p, and hsa-miR-193a-5p) accurately predicted postoperative and posttransplantation malignancy recurrence in HCC patients and was also valuable for prognostic evaluation of HCC patients. +other 36376850 hsa-mir-139 Carcinoma, Hepatocellular 3p, and hsa-miR-193a-5p) accurately predicted postoperative and posttransplantation malignancy recurrence in HCC patients and was also valuable for prognostic evaluation of HCC patients. +other 36376850 hsa-mir-767 Carcinoma, Hepatocellular 3p, and hsa-miR-193a-5p) accurately predicted postoperative and posttransplantation malignancy recurrence in HCC patients and was also valuable for prognostic evaluation of HCC patients. +lncRNA target 36376845 hsa-mir-340 Liver Cirrhosis, Hepatitis Virus B-Related 5p and their potential targets, which may help to develop non-invasive prognostic markers or intervention targets for HBV-LC. +lncRNA target 36376845 hsa-mir-20a Liver Cirrhosis, Hepatitis Virus B-Related 5p and their potential targets, which may help to develop non-invasive prognostic markers or intervention targets for HBV-LC. +epigenetics 36376550 hsa-mir-29c Lung Neoplasms CircTFF1 Promotes Proliferation, Migration and Invasion of Lung Cancer Cells by Facilitating Methylation of BCL6B Promoter via miR-29c-3p/DNMT3A Axis. +other 36375570 hsa-mir-145 Breast Neoplasms KEY FINDINGS: Based on bioinformatics analyses, CCAT2, AKT3, and mTOR were up-regulated in breast cancer cell lines, tissues, and TAM-resistant cells, while hsa-miR5p was down-regulated. +transcription factor target 36375474 hsa-mir-570 Colorectal Neoplasms CONCLUSIONS: The present study reveals that ZnC slows the progression of CRC by inhibiting CRC cells in terms of proliferation, invasion and migration, meanwhile up-regulating PD-L1 expression via inhibiting miR-570. +virus_miRNA 36374933 bkv-mir-B1 Kidney Transplantation Urine exosomal bkv-miR-B1-5p was associated with BKVN as were urine and plasma BKV DNA loads on serial follow-up, and might have potential as a predictive marker for BKVN during the early post-transplant period. +lncRNA target 36374810 hsa-mir-3677 Uterine Cervical Neoplasms TRAF3IP2-AS1 may play a tumor-suppressor role in cervical cancer progression by sponging miR +other 36374808 hsa-mir-148b Carotid Stenosis Pearson analysis was used to analyze the relationship between HOTAIR and miR-148b-3p in patients with CAS. Reduction of miR-148b-3p expression was substantiated in CAS patients. +other 36374807 hsa-mir-130a Thyroid Neoplasms TYMSOS and myristoylated alanine rich protein kinase C substrate like 1 (MARCKSL1) were upregulated whereas miR-130a-5p was downregulated in THCA cells and tissues. Collectively, TYMSOS facilitates THCA progression by sponging miR-130a-5p and upregulating MARCKSL1 to activate the PI3K/Akt signaling pathway, providing new avenues for THCA treatment. +transcription factor target 36374798 hsa-mir-424 Carcinoma, Hepatocellular Therefore, ultrasound-mediated targeted NBs are a potential effective carrier for liver cancer, and PD-L1 antibody and miR-424 have a synergistic anti-tumor immunotherapy effect. +other 36374774 hsa-mir-32 Colorectal Neoplasms Meanwhile, we found that the transcription factor SP1 activated PROX1-AS1/miR-32/FBXL20 axis, thereby promoting CRC progression. +other 36374443 hsa-mir-497 Urinary Bladder Neoplasms RESULTS: CEP55 expression as well as the expression levels of the oncogenic proteins PTHLH and HMGA2 were upregulated in BC cells while miR5p was downregulated. +genetics_GWAS 36374407 hsa-mir-495 Large-Artery Atherosclerosis Stroke MiR-200b rs7549819 and miR-495 rs2281611 polymorphisms were genotyped among 712 large-artery atherosclerosis (LAA) stroke patients and 1,076 controls in a case-control study. MiR-200b rs7549819 polymorphism and the combined genotypes of miR-200b rs7549819 and miR-495 rs2281611 polymorphisms were associated with decreased risk of LAA stroke in Chinese population. +genetics_GWAS 36374407 hsa-mir-200b Large-Artery Atherosclerosis Stroke MiR-200b rs7549819 and miR-495 rs2281611 polymorphisms were genotyped among 712 large-artery atherosclerosis (LAA) stroke patients and 1,076 controls in a case-control study. MiR-200b rs7549819 polymorphism and the combined genotypes of miR-200b rs7549819 and miR-495 rs2281611 polymorphisms were associated with decreased risk of LAA stroke in Chinese population. +transcription factor target 36374403 hsa-mir-23a Colonic Neoplasms This study demonstrated the mechanism of miR-23a-3p in CC, which may offer a new target for CC therapy. +other 36374119 hsa-mir-143 Urinary Bladder Neoplasms Besides, miR-143 is a promising candidate biomarker for diagnosing BCa. +lncRNA target 36372373 hsa-mir-140 Ischemic Stroke 3p directly targets Tyro3 to regulate cell viability and apoptosis of OGD/R-exposed N2a cells through the PI3K/Akt pathway, suggesting that miR +genetics_knock down_promote 36371782 hsa-mir-1294 Stomach Neoplasms RESULTS: The levels of hsa_circ_0043691 and PBX3 were upregulated, whereas miR-1294 expression was diminished in GC tissues and cells. CONCLUSION: Hsa_circ_0043691 knockdown repressed GC malignant phenotypes by miR-1294/PBX3 axis, which exhibited a novel therapeutic target for GC treatment. +other 36371775 hsa-mir-4739 Adenocarcinoma of Lung RESULTS: The expression levels of LINC00511 and PYCR1 in LUAD were downregulated, whereas that of miR-4739 was upregulated. CONCLUSION: This study demonstrates for the first time that LINC00511 aggravates the malignancy of LUAD by sponging miR-4739 to upregulate PYCR1 expression. +genetics_GWAS 36371555 hsa-mir-149 Breast Neoplasms Therefore, human blood samples and breast cancer cell line (MCF7) were analyzed to study any possible association between the genetic variant (rs2292832) in the miR-149 precursor and breast cancer susceptibility. METHODS: To study the role of rs2292832 polymorphism in breast cancer, the miR-149 gene variant was genotyped using PCR-RFLP. +lncRNA target 36371491 hsa-mir-195 Triple Negative Breast Neoplasms 5p/PSAT1 in TNBC, suggesting a promising targeted therapy for clinical application. +genetics_knock down_suppress 36371182 hsa-mir-127 Breast Neoplasms The knockdown of miR-127 substantially increased, whereas overexpression decreased BC cell proliferation, invasion, and migration. +other 36370665 hsa-mir-326 Colorectal Neoplasms 5p to promotes PGAM1 expression, which further promoted CRC immune escape by activating glycolysis and inactivating the anti-CTLA-4 therapy response of CRC. +other 36370665 hsa-mir-30 Colorectal Neoplasms 5p to promotes PGAM1 expression, which further promoted CRC immune escape by activating glycolysis and inactivating the anti-CTLA-4 therapy response of CRC. +lncRNA target 36370637 hsa-mir-146a Rhinitis, Allergic Treatment with ESP-B4 relieved AR in rats, and elevated miR-146a-5p in the EVs from the nasal epithelial cells, apparently in relation to effects on helper T cell Th1/Th2 equilibrium. CONCLUSION: Overall, ESP-B4 can promote miR-146a-5p secretion, affect the Th1/Th2 balance of helper T cells, and relieve AR symptoms through Smad3/GATA-3 interaction, thus presenting a potential strategy for AR treatment. +transcription factor target 36370225 hsa-mir-200a Memory Disorders Our findings imply that miR-200a-3p/Mct2 in the hippocampus would be a possible clinical target for treating T2DM-induced memory dysfunction. +lncRNA target 36369960 hsa-mir-493 Cholangiocarcinoma 5p in EVs. +genetics_overexpression_suppress 36369900 hsa-mir-135b Ovarian Neoplasms Circ_0000471 served as a molecular sponge for microRNA-135b-5p (miR-135b-5p), and circ_0000471 overexpression-mediated anti-tumor influences in OC cells were largely reversed by the overexpression of miR-135b-5p. +other 36369887 hsa-mir-99a Osteoporosis Whether long non-coding RNA Mir-99a-Let-7c Cluster Host Gene (LncRNA MIR99AHG) is involved in osteoporosis (OP) remains vague, so we hereby center on its implication. +other 36369887 hsa-mir-99a Osteoporosis-pseudoglioma syndrome Whether long non-coding RNA Mir-99a-Let-7c Cluster Host Gene (LncRNA MIR99AHG) is involved in osteoporosis (OP) remains vague, so we hereby center on its implication. +circulation_biomarker_diagnosis_up 36369742 hsa-mir-210 Disorders of Sex Development CONCLUSION: Our study showed a positive association between the presence of atypical genitalia and plasma levels of miR-210 expression in the group of patients with 46,XY DSD of unknown aetiology studied. +other 36369467 hsa-mir-654 Pancreatic Carcinoma Importantly, we found that circRNF13 promoted PDK3 levels by acting as a miR3p sponge, thus promoting the PC malignant process. +circulation_biomarker_diagnosis_up 36369428 hsa-mir-19b Hypoxia-Ischemia, Brain The expression of miR-19b-3p and SOX6 in umbilical blood of HIE patients was detected by qRT-PCR assay. MiR-19b-3p expression was once down-regulated, whilst SOX6 expression was up-regulated in HIE patients. +lncRNA target 36368448 hsa-mir-363 Pre-Eclampsia Furthermore, in vivo experiments noted that RES alleviated placental injury and promoted angiogenesis in rats with PE-like symptoms in vivo by increasing VEGF via promoting miR +lncRNA target 36368065 hsa-mir-144 Myocardial Infarction After intervening the expression of miR-144 by microinjecting and activating Wnt pathway by an agonist BML-284, we confirmed that up-regulated miR-144 suppressed the expression of angiogenesis-related genes and negatively regulated Wnt pathway, further triggering angiogenesis disorders and cardiac phenotypic malformation. +other 36367679 hsa-mir-34a Cognition Disorders "The major pathways associated with memantine and donepezil countering cognitive impairment generated by mixed EDCs were discovered to be ""AGE-RAGE signaling pathway in diabetic complications,"" ""pro-survival signaling of neuroprotectin D1,"" and ""non-alcoholic fatty liver disease."" The miRNAs and transcription factors implicated in memantine and donepezil protecting against mixed EDCs were hsa-miR3p and hsa-miR-34a-5p, NFKB1, NFKB2, IRF8, and E2F4." +other 36367679 hsa-mir-128 Cognition Disorders "The major pathways associated with memantine and donepezil countering cognitive impairment generated by mixed EDCs were discovered to be ""AGE-RAGE signaling pathway in diabetic complications,"" ""pro-survival signaling of neuroprotectin D1,"" and ""non-alcoholic fatty liver disease."" The miRNAs and transcription factors implicated in memantine and donepezil protecting against mixed EDCs were hsa-miR3p and hsa-miR-34a-5p, NFKB1, NFKB2, IRF8, and E2F4." +lncRNA target 36367621 hsa-mir-17 Colonic Neoplasms 3p regulated CC cell malignant progression, as well as apoptosis by targeting PLCD1. +lncRNA target 36367475 hsa-mir-125b Ischemic Stroke MSC-EVs inhibit astrocyte activation and associated inflammation through miR-125b-5p/TLR4/NF-kappaB pathway. +lncRNA target 36366842 hsa-mir-6938 Stomach Neoplasms CONCLUSION: Taken together, our findings demonstrated that circSNTB2 plays an essential role in gastric cancer by regulating miR5p through G0S2 and PDCD4 genes. +lncRNA target 36366818 hsa-mir-3682 Carcinoma, Hepatocellular In addition, inhibition of PTEN weakened the anti-migration and anti-stemnesic effects of miR +target gene 36366788 hsa-mir-151a Colorectal Neoplasms miR-30d-5p and miR-151a-3p, altered in CRC tissue, were also dysregulated in stool of CRC patients and urine of BC cases, respectively. +other 36366542 hsa-let-7f Asthma 3p, were identified between asthmatic and healthy subjects after inoculation with RV. +other 36366542 hsa-mir-126 Asthma 3p, were identified between asthmatic and healthy subjects after inoculation with RV. +other 36366542 hsa-let-7a Asthma 3p, were identified between asthmatic and healthy subjects after inoculation with RV. +other 36366542 hsa-mir-122 Asthma 3p, were identified between asthmatic and healthy subjects after inoculation with RV. +other 36366542 hsa-mir-101 Asthma 3p, were identified between asthmatic and healthy subjects after inoculation with RV. +other 36362375 hsa-mir-101 Carcinoma, Hepatocellular 3p/TKTL1) associated with the progression of HCC under hypoxia. +lncRNA target 36361993 hsa-mir-34a Colorectal Neoplasms In conclusion, RF-EMF strongly influenced regulation mediated by the tumour suppressor miR-34a on the peripheral circadian oscillator in DLD1 cells. +lncRNA target 36361979 hsa-mir-1 Fibrosis 5p show the potential to inhibit LEC-dependent fibrosis. +genetics_knock down_suppress 36361843 hsa-mir-143 Obesity Importantly, during high fat diet-induced obesity, miR-143KO significantly reduced body weight, and improved energy expenditure, insulin sensitivity, and glucose tolerance. +other 36361623 hsa-mir-223 Sexual Dysfunctions, Psychological 3p and miR-26a-5p. +other 36361623 hsa-mir-21 Genital Diseases, Female 3p and miR-26a-5p. +other 36361623 hsa-mir-128 Genital Diseases, Female 3p and miR-26a-5p. +other 36361623 hsa-mir-92a Sexual Dysfunctions, Psychological 3p and miR-26a-5p. +other 36361623 hsa-mir-92a Genital Diseases, Female 3p and miR-26a-5p. +other 36361623 hsa-mir-21 Sexual Dysfunctions, Psychological 3p and miR-26a-5p. +other 36361623 hsa-mir-142 Sexual Dysfunctions, Psychological 3p and miR-26a-5p. +other 36361623 hsa-mir-26a Sexual Dysfunctions, Psychological 3p and miR-26a-5p. +other 36361623 hsa-mir-15a Sexual Dysfunctions, Psychological 3p and miR-26a-5p. +other 36361623 hsa-mir-128 Sexual Dysfunctions, Psychological 3p and miR-26a-5p. +other 36361623 hsa-mir-142 Genital Diseases, Female 3p and miR-26a-5p. +other 36361623 hsa-mir-26a Genital Diseases, Female 3p and miR-26a-5p. +other 36361623 hsa-mir-15a Genital Diseases, Female 3p and miR-26a-5p. +other 36361623 hsa-mir-223 Genital Diseases, Female 3p and miR-26a-5p. +other 36360309 hsa-mir-1255b Diabetes Mellitus, Type 2 SLC25A4, PLCB1, AGTR2, PRKN, and SCD5 were shown to be important mRNAs in T2DM, and miR-199b-5p, miR5p, miR-548o-3p as well as miR-1255b-5p could be involved in their regulation. +other 36360309 hsa-mir-548o Diabetes Mellitus, Type 2 SLC25A4, PLCB1, AGTR2, PRKN, and SCD5 were shown to be important mRNAs in T2DM, and miR-199b-5p, miR5p, miR-548o-3p as well as miR-1255b-5p could be involved in their regulation. +other 36360258 hsa-mir-203b Food Hypersensitivity Logistical regression models revealed that the addition of multi-omic features (miR-203b-3p, Cyanobacteria, and Proteus virus PM135) improved predictiveness for future FRs in infants (p = 0.005, X(2) = 12.9), predicting FRs with 72% accuracy (AUC = 0.81, sensitivity = 72%, specificity = 72%). +transcription factor target 36360255 hsa-mir-431 Premature Birth Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR +transcription factor target 36360255 hsa-mir-487b Premature Birth Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR +transcription factor target 36360255 hsa-mir-432 Premature Birth Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR +transcription factor target 36360255 hsa-mir-127 Premature Birth Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR +transcription factor target 36360255 hsa-mir-134 Premature Birth Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR +transcription factor target 36360255 hsa-mir-23b Premature Birth Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR +transcription factor target 36360255 hsa-mir-485 Premature Birth Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR +transcription factor target 36360255 hsa-mir-382 Premature Birth Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR +transcription factor target 36360255 hsa-mir-493 Premature Birth Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR +transcription factor target 36360255 hsa-mir-369 Premature Birth Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR +transcription factor target 36360255 hsa-mir-34c Premature Birth Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR +transcription factor target 36360255 hsa-mir-122 Premature Birth Using high-throughput sequencing technology we detected differences in the levels of 15 miRNAs (3 upregulated-hsa-miR +transcription factor target 36359915 hsa-mir-199a Mastitis Despite its importance in humans and animals, the molecular mechanism of bovine miR-199a-3p (bta-miR-199a-3p) in dairy cow mastitis and bovine mammary epithelial cell (bMEC) inflammation is unclear. This study reveals the potential regulatory mechanism of bta-miR-199a-3p in bMEC inflammatory immune response and may serve as a useful target for the treatment of mastitis. +lncRNA target 36359915 hsa-mir-199a Inflammation Thus, bta-miR-199a-3p inhibits LPS-induced inflammation in bMECs by directly targeting CD2AP and regulating the PI3K/AKT/NF-kappaB signaling pathway. +lncRNA target 36359873 hsa-mir-1264 Chondrosarcoma Our results indicate that visfatin inhibits miR-1264 production through the PI3K/Akt/mTOR signaling cascade, and thereby promotes PDGF-C expression and chondrosarcoma angiogenesis. +lncRNA target 36359865 hsa-mir-374 Hepatocellular Carcinoma, Hbv-Related 5p/FOXO1 pathway were significantly dysregulated in HCC, and validation in vitro showed that FOXO1 is positively regulated by MAGI2-AS3 through the induction of miR-374a/b-5p in HCC cells. +transcription factor target 36359857 hsa-mir-397 Hepatolenticular Degeneration MIR397 (involved in drought, low temperature, and nitrogen and copper (Cu) starvation) and MIR408 (differentially expressed in response to environmental stresses such as copper, light, mechanical stress, dehydration, cold, reactive oxygen species, and drought) belong to conserved MIRNA families that either negatively or positively regulate their target genes. +transcription factor target 36359857 hsa-mir-397 Dehydration MIR397 (involved in drought, low temperature, and nitrogen and copper (Cu) starvation) and MIR408 (differentially expressed in response to environmental stresses such as copper, light, mechanical stress, dehydration, cold, reactive oxygen species, and drought) belong to conserved MIRNA families that either negatively or positively regulate their target genes. +transcription factor target 36359857 hsa-mir-408 Dehydration MIR397 (involved in drought, low temperature, and nitrogen and copper (Cu) starvation) and MIR408 (differentially expressed in response to environmental stresses such as copper, light, mechanical stress, dehydration, cold, reactive oxygen species, and drought) belong to conserved MIRNA families that either negatively or positively regulate their target genes. +transcription factor target 36359857 hsa-mir-408 Hepatolenticular Degeneration MIR397 (involved in drought, low temperature, and nitrogen and copper (Cu) starvation) and MIR408 (differentially expressed in response to environmental stresses such as copper, light, mechanical stress, dehydration, cold, reactive oxygen species, and drought) belong to conserved MIRNA families that either negatively or positively regulate their target genes. +exosome 36359855 hsa-mir-140 Diabetes, Gestational These findings indicate that chemerin reduces placenta-derived exosomal miR +exosome 36359855 hsa-mir-574 Diabetes, Gestational These findings indicate that chemerin reduces placenta-derived exosomal miR +genetics_overexpression_promote 36359774 hsa-mir-21 Alzheimer Disease In AD neurons, miR-124/miR-21 overexpression was recapitulated in their exosomes. +circulation_biomarker_diagnosis_ns 36359344 hsa-mir-125b Hepatitis B, Chronic This study aimed to investigate the association between serum miR-125b and liver fibrosis progression in chronic hepatitis B (CHB) patients after nucleos(t)ide analog (NA) treatment. In 59 patients receiving entecavir (ETV) monotherapy, the alternation of serum miR-125b in 12 months and age were substantially associated with a higher post-treatment FIB-4 index (>2.9), suggesting that miR-125b is a reliable biomarker for detecting early liver fibrosis under specific anti-HBV NA treatments (e.g., ETV). +circulation_biomarker_diagnosis_ns 36359344 hsa-mir-125 Hepatitis B, Chronic This study aimed to investigate the association between serum miR-125b and liver fibrosis progression in chronic hepatitis B (CHB) patients after nucleos(t)ide analog (NA) treatment. In 59 patients receiving entecavir (ETV) monotherapy, the alternation of serum miR-125b in 12 months and age were substantially associated with a higher post-treatment FIB-4 index (>2.9), suggesting that miR-125b is a reliable biomarker for detecting early liver fibrosis under specific anti-HBV NA treatments (e.g., ETV). +other 36358979 hsa-mir-122 Hepatitis C By complementing miR-122 at the 5' end of the genome, the hepatitis C virus (HCV) gene can form a complex with Argonaute 2 (Ago2) protein to protect the 5' end of HCV RNA from exonucleolytic attacks. +lncRNA target 36357766 hsa-mir-217 Breast Neoplasms miR-217 repressed sensitivity against anti-cancer drugs by inducing autophagy of BC cells through the NF1/HSF1/ATG7 axis. +lncRNA target 36357715 hsa-mir-125b Alzheimer Disease  Altogether, these results indicate that neuronal NSun2 deficiency promotes dysregulation of miR-125b and tau phosphorylation in AD and highlights a novel avenue for therapeutic targeting. +other 36357650 hsa-mir-1225 Uterine Cervical Neoplasms Collectively, the present study indicates that hsa_circ_0001627 regulates miR5p/FNDC3B/PI3K/mTOR axis and functions as an oncogene in CC progression, suggesting the potential therapeutic use of hsa_circ_0001627 in CC treatment. +genetics_knock down_suppress 36356793 hsa-mir-146a Epidermodysplasia Verruciformis Our previous study demonstrated that exosomes released from Enterovirus 71 (EV71)-infected cells contained replication-competent EV71 RNA in complex with miR-146a, Ago2, and GW182, which can be successfully transferred to recipient/target cells to establish productive infection. Knockdown of GW182 or Ago2 could weaken the replication ability of exosomal EV71 RNA in recipient cells through decreasing the amount of miR-146a in exosomes, but did not affect the package of viral RNA into exosomes. +exosome 36356793 hsa-mir-146a Enterovirus Infections Our previous study demonstrated that exosomes released from Enterovirus 71 (EV71)-infected cells contained replication-competent EV71 RNA in complex with miR-146a, Ago2, and GW182, which can be successfully transferred to recipient/target cells to establish productive infection. +circRNA target 36356557 hsa-mir-758 Breast Neoplasms 3p, which might be a novel strategy for breast cancer suppression. +lncRNA target 36356379 hsa-mir-93 Carcinoma, Renal Cell 5p was downregulated in clinical samples with renal stones and negatively targeted Pknox1. +lncRNA target 36356379 hsa-mir-93 Kidney Calculi 5p was downregulated in clinical samples with renal stones and negatively targeted Pknox1. +genetics_overexpression_promote 36356335 hsa-mir-432 Squamous Cell Carcinoma of Head and Neck 5p was inhibited or DNMT3B was overexpressed, the growth and EMT of LSCC cells were stimulated despite ciRS-7 silencing. +other 36355333 hsa-mir-148a Alzheimer Disease One of these genes, hsa-miR-148a-3p, might be considered as a new biomarker for Alzheimer's disease diagnosis. +genetics_knock down_promote 36355210 hsa-mir-223 Stomach Neoplasms 3p) in GC cell biology and signaling pathway activation were examined by targeted knockdown (KD) or overexpression (OE) of ECT2 and miR +other 36354672 hsa-mir-130b Glioblastoma 3p, and -34a-5p not only in the formation of NS, but also in the regulation of malignant growth and invasion of GBM. +genetics_overexpression_promote 36354205 hsa-mir-96 Uterine Cervical Neoplasms TRIM52-AS1 inhibition or IGF2BP2 overexpression neutralized the inhibition of silencing miR +circulation_biomarker_diagnosis_up 36354186 hsa-mir-3 Spinal Cord Injuries 5p upregulation alleviated the leakage of the blood-spinal cord barrier (BSCB) induced by SCI and improved the neurological functions of SCI rats, as evidenced by the Basso, Beattie, and Bresnahan (BBB) scores and Evans blue staining. +other 36353991 hsa-mir-223 Thyroid Cancer, Papillary RESULTS: Myocardial infarction induces platelets internalization, resulting in the release of miR3p, a platelet-enriched miRNA. +other 36353991 hsa-mir-223 Myocardial Infarction RESULTS: Myocardial infarction induces platelets internalization, resulting in the release of miR3p, a platelet-enriched miRNA. +transcription factor target 36353937 hsa-mir-550a Carcinoma, Hepatocellular In addition, we also found that miR-550a-5p could suppress the growth of HCC in vivo via a xenograft tumor model assay. +circulation_biomarker_prognosis_ns 36353917 hsa-mir-223 Respiratory Distress Syndrome Thus, circulating MV-miR-223 may be a potential biomarker in prognosticating patient-centered outcomes and predicting mortality in ARDS. +circulation_biomarker_prognosis_up 36353665 hsa-mir-155 Diabetic Foot CONCLUSION: The increased expression of miR-155 in peripheral blood of T2DM patients is closely related to the occurrence of DFU. +circulation_biomarker_prognosis_up 36353665 hsa-mir-155 Diabetes Mellitus, Type 2 CONCLUSION: The increased expression of miR-155 in peripheral blood of T2DM patients is closely related to the occurrence of DFU. +transcription factor target 36353514 hsa-mir-424 Premature Birth Through bioinformatics analysis on DEGs, we identified four key miRNAs, - miR +transcription factor target 36353514 hsa-mir-424 Trophoblast Dysfunction Through bioinformatics analysis on DEGs, we identified four key miRNAs, - miR +transcription factor target 36352829 hsa-mir-543 Parkinson Disease Our results highlight the idea that dysregulation of miR-543 in early PD white matter, resulting in the dysregulation of SIRT1, potentially influencing the early white matter changes observed in PD. +circRNA target 36352482 hsa-mir-217 Endometrial Neoplasms hsa_circ_0023404 inhibit miR-217 as sponge which inhibit endometrial cancer cell growth and metastasis. +circulation_biomarker_prognosis_up 36352360 hsa-mir-451 Cholangiocarcinoma RESULTS: The tissue and serum expression of miR-451 was decreased in cholangiocarcinoma compared with corresponding normal samples. +other 36352275 hsa-mir-423 Glioma Finally, miR3p's biological functions of in effecting the cell proliferative, migratory, and invasive capabilities of glioma were investigated by performing Cell Counting Kit-8 (CCK-8) and Transwell assays. +lncRNA target 36352177 hsa-let-7a Glioma CONCLUSIONS: Altogether, our data demonstrated that lncRNA MIAT could control proliferation, migration, and metastasis of brain cancer cells via regulating the Nanog/ Sox2 / let-7a-5p / miR-29b-3p axis. +lncRNA target 36352177 hsa-mir-29b Glioma CONCLUSIONS: Altogether, our data demonstrated that lncRNA MIAT could control proliferation, migration, and metastasis of brain cancer cells via regulating the Nanog/ Sox2 / let-7a-5p / miR-29b-3p axis. +transcription factor target 36352176 hsa-mir-34a Triple Negative Breast Neoplasms We found that p53 could inhibit the expression of PD-L1 via miR-34a and that miR-34a could inhibit both cell activity and migration and promoted apoptosis and cytotoxicity in TNBC. +lncRNA target 36352081 hsa-mir-195 Small Cell Lung Carcinoma 5p/CHEK1 ceRNA regulatory aixs may play vital roles in the occurrence and development of NSCLC, and may provide novel therapeutic targets in the future. +lncRNA target 36352081 hsa-mir-101 Small Cell Lung Carcinoma 5p/CHEK1 ceRNA regulatory aixs may play vital roles in the occurrence and development of NSCLC, and may provide novel therapeutic targets in the future. +other 36351608 hsa-mir-210 Bacterial Infections At that time, we started research on RNA and bacterial infection and revealed that miR-210, a small RNA in the gastric epithelial cells, is involved in gastric diseases caused by Helicobacter pylori in-fection. +other 36351549 hsa-mir-1 Endothelial Barrier Dysfunction AGEs induced endothelial cell senescence and endothelial barrier dysfunction by regulating miR3p/MLCK signaling pathway. +other 36351490 hsa-mir-133a Simian Acquired Immunodeficiency Syndrome Myotube-derived EVs from CBA animals had decreased miR-16 (p = 0.04) and increased miR-133a and miR-133b (both p = 0.04) expression. +other 36351490 hsa-mir-16 Simian Acquired Immunodeficiency Syndrome Myotube-derived EVs from CBA animals had decreased miR-16 (p = 0.04) and increased miR-133a and miR-133b (both p = 0.04) expression. +other 36351490 hsa-mir-133b Simian Acquired Immunodeficiency Syndrome Myotube-derived EVs from CBA animals had decreased miR-16 (p = 0.04) and increased miR-133a and miR-133b (both p = 0.04) expression. +genetics_GWAS 36350621 hsa-mir-28 Myopia 3p as a novel risk factor for myopia through a genetic association study of the PAX6 gene. +transcription factor target 36350418 hsa-mir-155 ankylosing spondylitis 1 Our primary objective was to explore the role of miR-155 and its targeted factors in AS pathogenesis. +circulation_biomarker_prognosis_ns 36350075 hsa-mir-195 Subarachnoid Hemorrhage 5p was lowly expressed in the serum of SAH patients and lower in SAH CVS patients. +circulation_biomarker_prognosis_ns 36350075 hsa-mir-195 Vasospasm, Intracranial 5p was lowly expressed in the serum of SAH patients and lower in SAH CVS patients. +other 36349193 hsa-mir-425 Squamous Cell Carcinoma of Head and Neck 5p) was generated, whose risk score was validated as an independent prognostic factor for HNSCC. +other 36349193 hsa-mir-141 Squamous Cell Carcinoma of Head and Neck 5p) was generated, whose risk score was validated as an independent prognostic factor for HNSCC. +other 36349193 hsa-mir-7 Squamous Cell Carcinoma of Head and Neck 5p) was generated, whose risk score was validated as an independent prognostic factor for HNSCC. +other 36349191 hsa-mir-1321 Glioma In conclusion, our findings showed that oncogene NQO1 and antioncogene miR-1321 bind to oncogene SERPINA1 to affect proliferation and apoptosis of glioma cells, which can bring new solution of antitumor treatments for glioma in the future. +other 36349063 hsa-mir-146b Heart Injuries Receiver operating characteristic curve and correlation analysis showed that cTnI and miR-146b had relatively high predictive values for chronic myocardial injury (area under the curve, 0.83 and 0.71, respectively) and were closely correlated with myocardial damage. These data suggested that CK, cTnI and FABP3 were relatively sensitive to DOX-induced acute myocardial injury, whereas cTnI and miR-146b were relatively sensitive to DOX-induced chronic myocardial injury. +other 36348805 hsa-mir-34a Fibrosis, Renal Tanshinone IIA improved DN-induced renal fibrosis by regulating miRNA-34a-5p in vitro and in vivo study. +other 36348805 hsa-mir-34a Diabetes Mellitus Tanshinone IIA improved DN-induced renal fibrosis by regulating miRNA-34a-5p in vitro and in vivo study. +other 36348568 hsa-mir-21 Carcinoma, Hepatocellular CONCLUSION: miR-21 has a moderate overall performance in diagnosing HCC and may serve as a potential non-invasive marker for this early-stage disease. +other 36348379 hsa-mir-27b Carcinoma, Hepatocellular Mechanistically, circRanGAP1 as an oncogene promotes HCC progression by miR-27b-3p/NRAS/ERK axis, furthermore, affects the infiltration level of tumor-associated macrophages probably by sponging miR-27b-3p. CONCLUSION: These results reveal that circRanGAP1 is a HCC oncogene that function by the miR-27b-3p/NRAS/ERK axis and regulates the infiltration levels of tumor-associated macrophages by sponging miR-27b-3p. +lncRNA target 36348305 hsa-mir-145 Colorectal Neoplasms 5p is a tumor suppressor at early stage of CRC, and an oncogene at advanced stage of CRC. +exosome 36348269 hsa-mir-150 Hyperalgesia CONCLUSION: BMSC-derived exosomal miR +transcription factor target 36348252 hsa-mir-122 Cholangiocarcinoma 5p was found to act as a post-transcriptional regulator of FUT8 and proved to inhibit FUT8 expression and then suppress the proliferation and migration ability of iCCA cell lines. +circulation_biomarker_diagnosis_up 36348199 hsa-mir-559 psoriasis 1 Furthermore, serum miRNA-559 and MTDH displayed comparable diagnostic accuracy in discriminating psoriatic patients from controls. +genetics_overexpression_promote 36348139 hsa-mir-29c Squamous Cell Carcinoma of Head and Neck Additionally, overexpressed C1QTNF6 facilitated these biological functions of HNSCC cells while upregulating miR-29c-3p reversed such effect. +other 36348020 hsa-mir-196b Colorectal Neoplasms METTL3 promotes colorectal cancer metastasis by promoting the maturation of pri-microRNA-196b. +lncRNA target 36347825 hsa-mir-138 Laryngeal Neoplasms 5p inhibitor. +lncRNA target 36347300 hsa-mir-26b Brain Injuries CONCLUSIONS: Collectively, our findings highlighted the ameliorative effect of miR-26b inhibition on EBI in SAH and the possible mechanism associated with the KLF4/STAT3/HMGB1 axis. +lncRNA target 36347300 hsa-mir-26b Subarachnoid Hemorrhage CONCLUSIONS: Collectively, our findings highlighted the ameliorative effect of miR-26b inhibition on EBI in SAH and the possible mechanism associated with the KLF4/STAT3/HMGB1 axis. +other 36346713 hsa-mir-498 Esophageal Neoplasms Downregulated lncRNA UCA1 acts as ceRNA to adsorb microRNA-498 to repress proliferation, invasion and epithelial mesenchymal transition of esophageal cancer cells by decreasing ZEB2 expression +lncRNA target 36346578 hsa-mir-1224 Diabetic Retinopathy All in all, SPAG5-AS1 attenuates diabetic retinal vascular dysfunction through miR5p/IRS-1 axis, providing a potential therapeutic strategy for DR. +transcription factor target 36345369 hsa-mir-34a Diabetic Nephropathies In conclusion, the above data suggested that AIF-1 regulated the levels of inflammation, oxidative stress, and autophagy in HRGECs via miR-34a/ATG4B pathway to contribute to the pathogenesis of diabetic kidney disease. +transcription factor target 36344974 hsa-mir-1199 Prostatic Hyperplasia 5p inhibitor increased SRD5A2 expression in BPH-1 cells. +lncRNA target 36344947 hsa-mir-21 Uterine Cervical Neoplasms CONCLUSIONS: MEG3 performing as ceRNA promotes cisplatin sensitivity in CC cells through the miR-21/PTEN axis. +circulation_biomarker_diagnosis_up 36344812 hsa-mir-27 Scleroderma, Systemic MiR-27a is a microRNA known for its role in the pathogenesis of fibrosis and cancer, both of which employ similar signaling pathways; hence we hypothesized that Mir-27a could be dysregulated in the blood of individuals affected by SSc and it might be useful in the diagnosis or treatment of this disease. +circulation_biomarker_diagnosis_up 36344812 hsa-mir-27a Scleroderma, Systemic MiR-27a is a microRNA known for its role in the pathogenesis of fibrosis and cancer, both of which employ similar signaling pathways; hence we hypothesized that Mir-27a could be dysregulated in the blood of individuals affected by SSc and it might be useful in the diagnosis or treatment of this disease. +genetics_overexpression_promote 36343886 hsa-mir-421 Carcinoma, Renal Cell Overexpression of miR-421 has reversed the anti-tumor function of circSCNN1A in RCC cells. +other 36343560 hsa-mir-148a Drug Hypersensitivity Each T-score on negative mood subscales of anger-hostility, confusion-bewilderment, depression-dejection, fatigue-inertia, and tension-anxiety was significantly negatively correlated with relative miR-148a expression in breast milk: a positive mood subscale vigor-activity T-score was significantly positively correlated with relative miR-148a expression in breast milk. +other 36343560 hsa-mir-148a Neurotic Disorders Each T-score on negative mood subscales of anger-hostility, confusion-bewilderment, depression-dejection, fatigue-inertia, and tension-anxiety was significantly negatively correlated with relative miR-148a expression in breast milk: a positive mood subscale vigor-activity T-score was significantly positively correlated with relative miR-148a expression in breast milk. +other 36343560 hsa-mir-148a Fatigue Each T-score on negative mood subscales of anger-hostility, confusion-bewilderment, depression-dejection, fatigue-inertia, and tension-anxiety was significantly negatively correlated with relative miR-148a expression in breast milk: a positive mood subscale vigor-activity T-score was significantly positively correlated with relative miR-148a expression in breast milk. +other 36343560 hsa-mir-148a Mood Disorders RESULTS: A significantly negative correlation was observed between relative miR-148a expression in breast milk and the total mood disturbance T-score. +other 36343560 hsa-mir-148a Substance Withdrawal Syndrome Each T-score on negative mood subscales of anger-hostility, confusion-bewilderment, depression-dejection, fatigue-inertia, and tension-anxiety was significantly negatively correlated with relative miR-148a expression in breast milk: a positive mood subscale vigor-activity T-score was significantly positively correlated with relative miR-148a expression in breast milk. +other 36343560 hsa-mir-148a Pituitary Diseases Each T-score on negative mood subscales of anger-hostility, confusion-bewilderment, depression-dejection, fatigue-inertia, and tension-anxiety was significantly negatively correlated with relative miR-148a expression in breast milk: a positive mood subscale vigor-activity T-score was significantly positively correlated with relative miR-148a expression in breast milk. +circulation_biomarker_diagnosis_ns 36343541 hsa-mir-513a Pancreatic Carcinoma Plasmids altering LINC01234, miR-513a-3p and H6PD expression were transfected into pancreatic cancer cells to assess the change in biological behaviors of pancreatic cancer cells. +lncRNA target 36343490 hsa-mir-10b Inflammatory Bowel Diseases Thus, miR-10b may be expected to be a new target for the treatment of IBD. +lncRNA target 36342850 hsa-mir-21 Triple Negative Breast Neoplasms This compound was incorporated into the design of a next-generation RiboTAC that targeted the microRNA-21 (miR-21) precursor and alleviated a miRassociated cellular phenotype in triple-negative breast cancer cells. +other 36341564 hsa-mir-125b Urinary Bladder Neoplasms Furthermore, the modulation of miR-34a and miR-125b gene expression in association with increased MAGE-A6 and MAGE-A11 genes could open a new horizon in the improvement of bladder cancer. +transcription factor target 36341347 hsa-mir-93 Polycystic Ovary Syndrome 5p as a new molecular target for improving the function of GCs in PCOS patients. +lncRNA target 36341225 hsa-mir-17 Metabolic Diseases TXNIP, which leads to activation of NLRP3, is considered as a potential target of miR +lncRNA target 36341225 hsa-mir-17 Diabetes, Gestational TXNIP, which leads to activation of NLRP3, is considered as a potential target of miR +genetics_knock down_suppress 36340580 hsa-mir-640 Osteosarcoma MCAM knockdown repressed OS cell growth and migration, while additional miR-640 depletion partially abolished the anticancer effects of MCAM knockdown in OS cells. +other 36340453 hsa-mir-135b Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +other 36340453 hsa-mir-98 Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +other 36340453 hsa-mir-191 Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +other 36340453 hsa-mir-146b Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +other 36340453 hsa-mir-150 Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +other 36340453 hsa-mir-29a Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +other 36340453 hsa-let-7b Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +other 36340453 hsa-mir-134 Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +other 36340453 hsa-mir-148a Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +other 36340453 hsa-mir-23b Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +other 36340453 hsa-mir-34c Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +other 36340453 hsa-mir-181d Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +other 36340453 hsa-mir-133b Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +other 36340453 hsa-mir-155 Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +other 36340453 hsa-mir-17 Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +other 36340453 hsa-let-7d Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +other 36340453 hsa-mir-29b Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +other 36340453 hsa-mir-125b Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +other 36340453 hsa-let-7f Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +other 36340453 hsa-mir-16 Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +other 36340453 hsa-mir-92a Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +other 36340453 hsa-mir-15a Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +other 36340453 hsa-mir-372 Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +other 36340453 hsa-mir-142 Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +other 36340453 hsa-mir-143 Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +other 36340453 hsa-mir-138 Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +other 36340453 hsa-mir-181c Breast Neoplasms Furthermore, several miRNAs were found to be differentially expressed explicitly in the different subtypes; luminal A (miR-23b, miR-142, miR-29a, miR-181d, miR-16, miR-29b, miR-155, miR-181c), luminal B (miR-148a, let-7d, miR-92a, miR-34c, let-7b, miR-15a), HER2+ (miR-125b, miR-134, miR-98, miR-143, miR-138, miR-135b) and triple negative breast cancer (miR-17, miR-150, miR-210, miR-372, let-7f, miR-191, miR-133b, miR-146b, miR-7). +lncRNA target 36339585 hsa-mir-326 Osteoarthritis Correspondingly, intracellular transfer of circPARD3B through OE-circPARD3B-SMSCs-sEV could postpone disease progression through a functional module regulated angiogenesis of circPARD3B-miRSIRT1, providing a novel therapeutic strategy for OA. +other 36338963 hsa-mir-141 Hemangioma, Infantile 5p) were significantly differentially expressed between IH and normal control (p < 0.05). +other 36338962 hsa-mir-147a Ovarian Neoplasms As a result, six genes (CDT1, CNIH4, CRLS1, LIMCH1, POC1A, and SNX13), and two miRNAs (mir-147a, and mir-103a-3p) were suggested as novel candidate prognostic biomarkers for ovarian cancer. +genetics_overexpression_suppress 36338839 hsa-mir-164 Dehydration The heterologous accumulation of miR164g in Arabidopsis thaliana results in enhanced sensitivity to drought stress, while overexpression of MsNAC022 in Arabidopsis and the cultivated apple line 'GL-3' (Malus domestica Borkh.) lead to enhanced tolerance to drought stress by raising the ROS scavenging enzymes activity and related genes expression levels, particularly PEROXIDASE (MsPOD). +circulation_biomarker_diagnosis_up 36338741 hsa-mir-1228 Breast Neoplasms Significant downregulation of serum exosomal miR-940 expression in breast cancer was detected using miR-191 and miR-1228, whereas no significant down or up regulation was observed with miR-484, miR-423 and miR-16. The absolute quantitative results showed that miR-940 was significantly downregulated in breast cancer serum exosomes, which was consistent with the results from the analysis using miR-191 or miR-1228 as reference genes. +circulation_biomarker_diagnosis_up 36338741 hsa-mir-191 Breast Neoplasms Significant downregulation of serum exosomal miR-940 expression in breast cancer was detected using miR-191 and miR-1228, whereas no significant down or up regulation was observed with miR-484, miR-423 and miR-16. The absolute quantitative results showed that miR-940 was significantly downregulated in breast cancer serum exosomes, which was consistent with the results from the analysis using miR-191 or miR-1228 as reference genes. +other 36338672 hsa-mir-519b Endometriosis The present study aimed to investigate whether LncRNA HOTAIR regulates cell invasion and migration in endometriosis by regulating the miR-519b-3p/PRRG4 pathway. +lncRNA target 36338027 hsa-mir-29a Laryngeal Neoplasms In conclusion, hBMSC-derived Exo with upregulated miR-29a-3p inhibited laryngocarcinoma progression via regulating PTEN, providing a potential diagnostic and therapeutic target in this disease. +target gene 36337243 hsa-mir-195 Uterine Cervical Neoplasms Scutellaria barbata D. Don inhibits cervical cancer cell proliferation, migration, and invasion via miR-195-5p/LOXL2 axis. +other 36337027 hsa-mir-320c Lung Neoplasms Moreover, miR-320c and miR-320d expression was higher in pre-diagnostic specimens collected within 2 years of LC diagnosis. Our results indicated that elevated levels of miR-320c and miR-320d may be early indications of imminent and advanced LC. +other 36337027 hsa-mir-320d Lung Neoplasms Moreover, miR-320c and miR-320d expression was higher in pre-diagnostic specimens collected within 2 years of LC diagnosis. Our results indicated that elevated levels of miR-320c and miR-320d may be early indications of imminent and advanced LC. +other 36336926 hsa-mir-30 Atherosclerosis CONCLUSION: These results suggested that circIRAK1 upregulated TRIM14 by interacting with miR5p, consequently contributing to ox-LDL-induced endothelial cell injury in AS. +exosome 36336217 hsa-mir-625 Colorectal Neoplasms The current results indicated that CAFs-Exo was directly internalized by CRC cells, and exosomal miR +other 36336032 hsa-mir-101a Reperfusion Injury CONCLUSION: Altogether, RGD1564534 elevates the expression of Dusp1 by competitively binding to miR-101a-3p, which facilitates mitochondrial autophagy-mediated inactivation of NLRP3 inflammasome and thus retards cerebral I/R injury. +genetics_overexpression_promote 36336031 hsa-mir-140 Subarachnoid Hemorrhage SAH rats were treated with the EVs sourced from microglia overexpressing miR +lncRNA target 36335997 hsa-mir-144 Schizophrenia 3p/ZBTB20/ERK/CREB1 signalling might be associated with schizophrenia-like abnormalities, suggesting potential therapeutic targets for future schizophrenia treatment. +genetics_knock down_suppress 36335987 hsa-mir-506 Ovarian Neoplasms CONCLUSION: XIST knockdown inhibited autophagy and carboplatin resistance of OC through FOXP1/protein kinase B (AKT)/mammalian target of rapamycin pathway by targeting miR +transcription factor target 36335879 hsa-mir-614 Breast Neoplasms 5p suppressed the expression of TXNRD1 by directly binding to the 3'-untranslated region (UTR), and TXNRD1 inhibition significantly repressed the proliferation and metastasis capacity of BC cells upon Cd exposure. +lncRNA target 36335706 hsa-mir-21 salivary gland adenoid cystic carcinoma 3p inhibit the salivary adenoid cystic carcinoma progression. +lncRNA target 36335706 hsa-mir-150 salivary gland adenoid cystic carcinoma 3p inhibit the salivary adenoid cystic carcinoma progression. +lncRNA target 36335706 hsa-mir-375 salivary gland adenoid cystic carcinoma 3p inhibit the salivary adenoid cystic carcinoma progression. +lncRNA target 36335706 hsa-mir-103a salivary gland adenoid cystic carcinoma 3p inhibit the salivary adenoid cystic carcinoma progression. +lncRNA target 36335706 hsa-mir-155 salivary gland adenoid cystic carcinoma 3p inhibit the salivary adenoid cystic carcinoma progression. +lncRNA target 36335706 hsa-mir-140 salivary gland adenoid cystic carcinoma 3p inhibit the salivary adenoid cystic carcinoma progression. +lncRNA target 36335706 hsa-mir-20a salivary gland adenoid cystic carcinoma 3p inhibit the salivary adenoid cystic carcinoma progression. +lncRNA target 36335706 hsa-mir-130a salivary gland adenoid cystic carcinoma 3p inhibit the salivary adenoid cystic carcinoma progression. +lncRNA target 36335706 hsa-mir-125a salivary gland adenoid cystic carcinoma 3p inhibit the salivary adenoid cystic carcinoma progression. +lncRNA target 36335706 hsa-mir-101 salivary gland adenoid cystic carcinoma 3p inhibit the salivary adenoid cystic carcinoma progression. +other 36335210 hsa-mir-23b Endometrial Neoplasms Decreased miR-23b expression was associated with worse survival of EC patients. +other 36335210 hsa-mir-199a Endometrial Neoplasms We found that miR-23b, miR-125b-5p, miR-199a-3p, miR3p, and miR-451a were downregulated in EC in comparison to HE. +other 36335210 hsa-mir-221 Endometrial Neoplasms We found that miR-23b, miR-125b-5p, miR-199a-3p, miR3p, and miR-451a were downregulated in EC in comparison to HE. +other 36335210 hsa-mir-146 Endometrial Neoplasms Moreover, the expression of miR-34a-5p and miR5p was higher in EC1 compared to EC2. +other 36335210 hsa-mir-34a Endometrial Neoplasms Moreover, the expression of miR-34a-5p and miR5p was higher in EC1 compared to EC2. +other 36335210 hsa-mir-125b Endometrial Neoplasms We found that miR-23b, miR-125b-5p, miR-199a-3p, miR3p, and miR-451a were downregulated in EC in comparison to HE. +other 36335210 hsa-mir-451a Endometrial Neoplasms We found that miR-23b, miR-125b-5p, miR-199a-3p, miR3p, and miR-451a were downregulated in EC in comparison to HE. +other 36334906 hsa-mir-1 Wounds and Injuries Downregulation of microRNA-31 (miR-31) and microRNA-132 (miR-132) has been associated with delayed wound healing. Taken together, this data proves that delivery of RALA/miR-31 and RALA/miR-132 from an alginate/polyvinyl alcohol/ciprofloxacin nanofibrous wound dressing constitutes an advanced therapy for wound healing, by accelerating wound closure and improving healed tissue quality. +other 36334906 hsa-mir-132 Wounds and Injuries Downregulation of microRNA-31 (miR-31) and microRNA-132 (miR-132) has been associated with delayed wound healing. Taken together, this data proves that delivery of RALA/miR-31 and RALA/miR-132 from an alginate/polyvinyl alcohol/ciprofloxacin nanofibrous wound dressing constitutes an advanced therapy for wound healing, by accelerating wound closure and improving healed tissue quality. +other 36334875 hsa-let-7f-1 Intervertebral Disc Degeneration 3p/Bmal1/autophagy axis provides a potential therapeutic strategy for the clinical treatment of IDD. +circRNA target 36334805 hsa-mir-888 Triple Negative Breast Neoplasms Furthermore, we found that inhibiting circRAD54L2 expression markedly reduced the invasion, metastasis, and proliferation of breast cancer cells via sponging of the miR-888 family, which downregulated the expression of pyruvate dehydrogenase kinase 1 (PDK1). CONCLUSION: Our results showed that circRAD54L2 could regulate PDK1 expression by sponging the miR-888 family competing for the ceRNA mechanism, indicating that circRAD54L2 may act as an essential upstream regulator and providing further mechanistic evidence to support the notion that circRAD54L2/miR-888s/PDK1 is a promising therapeutic target in the treatment of breast cancer. +genetics_knock down_promote 36334791 hsa-mir-19a Neuralgia To investigate into the role of miR-19a-3p and KLF7 in NP of rats, the knockdown of miR-19a-3p alone or along with KLF7 downregulation in rats were achieved through lentivirus injection. +other 36334781 hsa-mir-9 Stress Disorders, Post-Traumatic Moreover, in the hippocampus, the PTSD(-) group showed decreased mRNA expression for corticotropin-releasing factor receptors type 1 and 2, increased mRNA expression for orexin receptor type 1, and decreased miR-9 and miR-34c levels compared with the PTSD(+) group. +other 36334781 hsa-mir-34c Stress Disorders, Post-Traumatic Moreover, in the hippocampus, the PTSD(-) group showed decreased mRNA expression for corticotropin-releasing factor receptors type 1 and 2, increased mRNA expression for orexin receptor type 1, and decreased miR-9 and miR-34c levels compared with the PTSD(+) group. +other 36334504 hsa-mir-106b Polycythemia, High Altitude 5p, hsa-miR-4433b-3p, hsa-miR-1291, and hsa-miR-106b-5p expression levels, while hsa-miR-200c-3p expression was downregulated. +other 36334504 hsa-mir-122 Polycythemia, High Altitude 5p, hsa-miR-4433b-3p, hsa-miR-1291, and hsa-miR-106b-5p expression levels, while hsa-miR-200c-3p expression was downregulated. +other 36334504 hsa-mir-200c Polycythemia, High Altitude 5p, hsa-miR-4433b-3p, hsa-miR-1291, and hsa-miR-106b-5p expression levels, while hsa-miR-200c-3p expression was downregulated. +other 36334504 hsa-mir-423 Polycythemia, High Altitude 5p, hsa-miR-4433b-3p, hsa-miR-1291, and hsa-miR-106b-5p expression levels, while hsa-miR-200c-3p expression was downregulated. +other 36334504 hsa-mir-1291 Polycythemia, High Altitude 5p, hsa-miR-4433b-3p, hsa-miR-1291, and hsa-miR-106b-5p expression levels, while hsa-miR-200c-3p expression was downregulated. +other 36334504 hsa-mir-4433b Polycythemia, High Altitude 5p, hsa-miR-4433b-3p, hsa-miR-1291, and hsa-miR-106b-5p expression levels, while hsa-miR-200c-3p expression was downregulated. +lncRNA target 36334219 hsa-mir-449a Cardiomyopathies Collectively, our study established CFAR as a new profibrotic factor acting through a novel miR-449a-5p/LOXL3/mTOR axis in the heart and therefore might be considered as a potential molecular target for the treatment of cardiac fibrosis and associated heart diseases. +circulation_biomarker_diagnosis_ns 36333771 hsa-mir-155 Acute Lung Injury 5p in the plasma. +circulation_biomarker_diagnosis_ns 36333771 hsa-mir-155 Pancreatitis 5p in the plasma. +other 36333728 hsa-mir-17 Diabetic Foot 3p had a negative regulatory effect on Flk-1. +transcription factor target 36333342 hsa-mir-584 Atherosclerosis These results suggest that OASL1/OASL regulates endothelial biology by protecting NOS3 mRNA and targeting miR-584 represents a rational therapeutic strategy for eNOS maintenance in vascular disease. +genetics_GWAS 36333293 hsa-mir-9 Squamous Cell Carcinoma of Head and Neck These results suggest a novel mechanism for EGFR inhibition of HPV E6/E7 oncoprotein expression through an epigenetic pathway, independent of MAPK, but mediated through microRNA +genetics_GWAS 36333293 hsa-mir-9 Endometrial Neoplasms These results suggest a novel mechanism for EGFR inhibition of HPV E6/E7 oncoprotein expression through an epigenetic pathway, independent of MAPK, but mediated through microRNA +genetics_overexpression_promote 36332797 hsa-mir-15a Colorectal Neoplasms Accordingly, overexpression of SIRT4 suppresses the miR-15a-5p-mediated enhancement in the proliferation, migration, and invasion of CRC cells, while the opposite phenotypes were observed after inhibition of SIRT4. +circulation_biomarker_diagnosis_up 36332335 hsa-mir-21 Colorectal Neoplasms Finally, we demonstrated the biomedical usefulness of this nanobiosensor platform with the multiplexed detection of upregulated miRNA targets, miR21 and miR221, from colorectal cancer patient plasma. +circulation_biomarker_diagnosis_up 36332335 hsa-mir-221 Colorectal Neoplasms Finally, we demonstrated the biomedical usefulness of this nanobiosensor platform with the multiplexed detection of upregulated miRNA targets, miR21 and miR221, from colorectal cancer patient plasma. +target gene 36331809 hsa-mir-18a Urinary Bladder Neoplasms LncRNA GAS5 regulates the Wnt/beta-catenin pathway through the miR-18a-5p/AXIN2/GSK3β axis to inhibit the proliferation and migration of bladder cancer cells. +genetics_knock down_promote 36331285 hsa-mir-152 Cholangiocarcinoma PDK1 overexpression reversed the inhibition effect of miR +circRNA target 36330643 hsa-mir-424 Osteoarthritis CONCLUSION: Hsa_circ_0004662 facilitates OA progression via the miR5p/VEGFA axis. +circulation_biomarker_prognosis_ns 36330573 hsa-mir-211 Vascular Calcification The receiver operating characteristic (ROC), Kaplan-Meier, and Cox regression analysis were carried out to analyze the predictive value of serum miR +circulation_biomarker_prognosis_ns 36330573 hsa-mir-211 Kidney Failure, Chronic The receiver operating characteristic (ROC), Kaplan-Meier, and Cox regression analysis were carried out to analyze the predictive value of serum miR +lncRNA target 36330459 hsa-mir-26a Ischemic Stroke CONCLUSIONS: TUG1/miR-26a, which may act as a regulatory axis in angiogenesis following ischemic stroke, can be considered a potential target for cerebral infarction therapy. +circulation_biomarker_diagnosis_up 36330052 hsa-mir-99a Squamous Cell Carcinoma of Head and Neck Furthermore, plasma EVs miR-99a-5p also distinguished early HNSCC with AUC of 0.7394 (95% CI: 0.6284-0.8504; p = 0.0002), with 79.07% sensitivity and 61.54% specificity, respectively. +circulation_biomarker_prognosis_up 36330017 hsa-mir-126 Infarct-Related Artery Total Occlusion 5p and miR-126 used as biomarkers in patients with AMI and infarct-related artery total occlusion (IR-ATO) or infarct-related blood-vessel recanalization (IR-BVR). +circulation_biomarker_prognosis_up 36330017 hsa-mir-21 Infarct-Related Artery Total Occlusion 5p and miR-126 used as biomarkers in patients with AMI and infarct-related artery total occlusion (IR-ATO) or infarct-related blood-vessel recanalization (IR-BVR). +circulation_biomarker_prognosis_up 36330017 hsa-mir-21 Myocardial Infarction, Acute 5p and miR-126 used as biomarkers in patients with AMI and infarct-related artery total occlusion (IR-ATO) or infarct-related blood-vessel recanalization (IR-BVR). +circulation_biomarker_prognosis_up 36330017 hsa-mir-126 Myocardial Infarction, Acute 5p and miR-126 used as biomarkers in patients with AMI and infarct-related artery total occlusion (IR-ATO) or infarct-related blood-vessel recanalization (IR-BVR). +lncRNA target 36329790 hsa-mir-153 Prostatic Neoplasms CONCLUSION: MiR-153 is up-regulated in PC tissues and may play an important role in aggressive PC by targeting potential target genes. +other 36329788 hsa-mir-129 Melanoma lncRNA-AC130710/miR-129-5p/mGluR1 axis promote migration and invasion by activating PKCα-MAPK signal pathway in melanoma. +genetics_knock down_promote 36329586 hsa-mir-4324 Breast Neoplasms CONCLUSIONS: High expression of Talin2 is associated with lymph node metastasis and HER-2 overexpression in breast cancer patients.Down-regulation of miR-4324 inhibits the proliferation, invasion and migration and induces apoptosis of breast cancer cells, and the inhibitory effect of miR-4324 knockdown on breast cancer cell migration is mediated probably by targeted inhibition of Talin2 expression. +transcription factor target 36329581 hsa-mir-16 Carcinoma, Non-Small-Cell Lung 5p can modulate the expressions of Bcl- 2 and Bax by targeted regulation of YWHAQ to modify the biological behaviors of paclitaxel-resistant breast cancer cells. +transcription factor target 36329581 hsa-mir-16 Breast Neoplasms 5p can modulate the expressions of Bcl- 2 and Bax by targeted regulation of YWHAQ to modify the biological behaviors of paclitaxel-resistant breast cancer cells. +genetics_knock down_promote 36329557 hsa-mir-637 Esophageal Squamous Cell Carcinoma Loss of miR-637 promotes cancer cell stemness via WASH/IL-8 pathway and serves as a novel prognostic marker in esophageal squamous cell carcinoma. +other 36329419 hsa-mir-155 Multiple Sclerosis CONCLUSION: Decreased expression of miRNA-145 and miRNA-155 contributes to development of relapse-remitting MS, while further large scale observational studies and meta-analyses are required. +other 36329419 hsa-mir-145 Multiple Sclerosis CONCLUSION: Decreased expression of miRNA-145 and miRNA-155 contributes to development of relapse-remitting MS, while further large scale observational studies and meta-analyses are required. +other 36328940 hsa-mir-141 Anorectal Malformations miR3p was downregulated in the ARM group, whereas Ubtd2 increased and colocalized with TUNEL-positive cells. +transcription factor target 36328305 hsa-mir-222 Spinal Cord Injuries 3p could alleviate the mitochondrial pathway-mediated apoptosis and motor dysfunction in rats after SCI by targeting Bbc3 and Bim. +lncRNA target 36328133 hsa-mir-374b Neovascularization, Pathologic Moreover, treatment of appropriate animal models either with a miR-374b-5p mimicry or with inhibitors of either stat3 acetylation, DNMT1, or EZH2, leads to marked inhibition of MCPpromoted neovascularization and tumor growth. +circulation_biomarker_diagnosis_ns 36328028 hsa-mir-1 Sarcopenia CONCLUSIONS: These results suggest that circulating miR +circulation_biomarker_diagnosis_ns 36328028 hsa-mir-1 Heart Failure, Chronic CONCLUSIONS: These results suggest that circulating miR +exosome 36327876 hsa-mir-29b Precursor Cell Lymphoblastic Leukemia-Lymphoma Extracellular vesicles derived from human bone marrow stem cells inhibit acute lymphoblastic leukemia cell growth by inhibiting MAPK pathway via the miR-29b-3p/GDF15 axis. +lncRNA target 36327779 hsa-mir-429 Carcinoma, Non-Small-Cell Lung Furthermore, through exploratory data analysis, we have reported four mRNAs (PLK1, ZNF300, NKX2-1, and EGR1), one lncRNA (UCA1) and five miRNAs (MIR133B, MIR326, MIR429, MIR451A, and MIR944) and MIR193A/UCA1/EGFR axis crucial to NSCLC mechanisms. +lncRNA target 36327779 hsa-mir-944 Carcinoma, Non-Small-Cell Lung Furthermore, through exploratory data analysis, we have reported four mRNAs (PLK1, ZNF300, NKX2-1, and EGR1), one lncRNA (UCA1) and five miRNAs (MIR133B, MIR326, MIR429, MIR451A, and MIR944) and MIR193A/UCA1/EGFR axis crucial to NSCLC mechanisms. +lncRNA target 36327779 hsa-mir-193a Carcinoma, Non-Small-Cell Lung Furthermore, through exploratory data analysis, we have reported four mRNAs (PLK1, ZNF300, NKX2-1, and EGR1), one lncRNA (UCA1) and five miRNAs (MIR133B, MIR326, MIR429, MIR451A, and MIR944) and MIR193A/UCA1/EGFR axis crucial to NSCLC mechanisms. +lncRNA target 36327779 hsa-mir-326 Carcinoma, Non-Small-Cell Lung Furthermore, through exploratory data analysis, we have reported four mRNAs (PLK1, ZNF300, NKX2-1, and EGR1), one lncRNA (UCA1) and five miRNAs (MIR133B, MIR326, MIR429, MIR451A, and MIR944) and MIR193A/UCA1/EGFR axis crucial to NSCLC mechanisms. +lncRNA target 36327779 hsa-mir-133b Carcinoma, Non-Small-Cell Lung Furthermore, through exploratory data analysis, we have reported four mRNAs (PLK1, ZNF300, NKX2-1, and EGR1), one lncRNA (UCA1) and five miRNAs (MIR133B, MIR326, MIR429, MIR451A, and MIR944) and MIR193A/UCA1/EGFR axis crucial to NSCLC mechanisms. +lncRNA target 36327779 hsa-mir-451a Carcinoma, Non-Small-Cell Lung Furthermore, through exploratory data analysis, we have reported four mRNAs (PLK1, ZNF300, NKX2-1, and EGR1), one lncRNA (UCA1) and five miRNAs (MIR133B, MIR326, MIR429, MIR451A, and MIR944) and MIR193A/UCA1/EGFR axis crucial to NSCLC mechanisms. +genetics_knock down_suppress 36327671 hsa-mir-145 Ovarian Neoplasms 5p reversed the effects of circ_0015756 knockdown on OC cells. +circulation_biomarker_diagnosis_ns 36327567 hsa-mir-106a hereditary diffuse gastric cancer The Cas13a-bHCR based SERS assay of gastric cancer-related miRNA-106a (miR-106a) can be achieved within 60 min and output significantly enhanced SERS signal due to the multiple signal amplification, which possesses a good linear calibration curve from 10 aM to 1 nM with the limit of detection (LOD) low to 8.55 aM for detecting gastric cancer-related miR-106a in human serum. +transcription factor target 36327448 hsa-mir-21 Breast Neoplasms To overcome these limitations, synergistic combinatorial anti-tumor effect of Granzyme B (GrB) and miR-21 inhibitor (miR-21i) for breast cancer therapy through a new co-delivery system was investigated in present study. In conclusion, the nanocapsules for simultaneously delivery of GrB and miR-21i produce a synergistic effect in human breast cancer therapy. +other 36327243 hsa-mir-199a Preterm Premature Rupture of the Membranes Pregnancies affected by PPROM were characterized by upregulation of miR-199a-5p, miR-130a-3p and miR-26a-5p and downregulation of miR-513b-5p (FDR adjusted p-values <0.05). +other 36327243 hsa-mir-26a Preterm Premature Rupture of the Membranes Pregnancies affected by PPROM were characterized by upregulation of miR-199a-5p, miR-130a-3p and miR-26a-5p and downregulation of miR-513b-5p (FDR adjusted p-values <0.05). +other 36327243 hsa-mir-130a Preterm Premature Rupture of the Membranes Pregnancies affected by PPROM were characterized by upregulation of miR-199a-5p, miR-130a-3p and miR-26a-5p and downregulation of miR-513b-5p (FDR adjusted p-values <0.05). +circulation_biomarker_diagnosis_ns 36327023 hsa-mir-367 Precursor Cell Lymphoblastic Leukemia-Lymphoma MATERIALS AND METHODS: The expression levels of serum miR-22, miR-122, miR-217, and miR-367 in 21 ALL patients and 21 healthy controls were measured using quantitative real-time PCR. Furthermore, ROC analysis showed that serum miR-217 and miR-367 could differentiate ALL patients from healthy individuals, while miR-22 has approximate discriminatory power that requires further investigation. +circulation_biomarker_diagnosis_ns 36327023 hsa-mir-22 Precursor Cell Lymphoblastic Leukemia-Lymphoma MATERIALS AND METHODS: The expression levels of serum miR-22, miR-122, miR-217, and miR-367 in 21 ALL patients and 21 healthy controls were measured using quantitative real-time PCR. Furthermore, ROC analysis showed that serum miR-217 and miR-367 could differentiate ALL patients from healthy individuals, while miR-22 has approximate discriminatory power that requires further investigation. +genetics_knock down_promote 36326978 hsa-mir-622 Glioma miR-622 knockdown reversed the effect of Propofol on glioma progression. +target gene 36326553 hsa-mir-29a Pneumonia LncRNA H19 via miR-29a-3p is involved in lung inflammation and pulmonary fibrosis induced by neodymium oxide. +target gene 36326553 hsa-mir-29a Pulmonary Fibrosis LncRNA H19 via miR-29a-3p is involved in lung inflammation and pulmonary fibrosis induced by neodymium oxide. +transcription factor target 36326533 hsa-mir-133a Hypercholesterolemia In conclusion, PDE can cause persistent enhancement of hepatic cholesterol synthesis function before and after birth through GR/miR-133a-3p/Sirt1 pathway, eventually leading to increased hypercholesterolemia susceptibility in female offspring rats. +other 36326316 hsa-mir-590 Tuberculosis 5p, miR-381, and miR-449a in the Pulmonary TB group, there was no significant change in miRNA expression in extrapulmonary TB patients. +other 36326316 hsa-mir-15a Tuberculosis 5p, miR-381, and miR-449a in the Pulmonary TB group, there was no significant change in miRNA expression in extrapulmonary TB patients. +other 36326316 hsa-mir-449a Tuberculosis 5p, miR-381, and miR-449a in the Pulmonary TB group, there was no significant change in miRNA expression in extrapulmonary TB patients. +other 36326316 hsa-mir-381 Tuberculosis 5p, miR-381, and miR-449a in the Pulmonary TB group, there was no significant change in miRNA expression in extrapulmonary TB patients. +other 36326316 hsa-mir-454 Tuberculosis 5p, miR-381, and miR-449a in the Pulmonary TB group, there was no significant change in miRNA expression in extrapulmonary TB patients. +lncRNA target 36326314 hsa-mir-8084 Prostatic Hyperplasia DISCUSSION: Our results suggested that determined common hsa-miR3p, hsa-miR-3128, hsa-miR-8084 and their target HIF1A, AVRP1A, NHS, INSL4 may play a crucial role in therapeutic and early diagnostic strategies for prostate cancer. +lncRNA target 36326314 hsa-mir-128 Prostatic Hyperplasia DISCUSSION: Our results suggested that determined common hsa-miR3p, hsa-miR-3128, hsa-miR-8084 and their target HIF1A, AVRP1A, NHS, INSL4 may play a crucial role in therapeutic and early diagnostic strategies for prostate cancer. +lncRNA target 36326314 hsa-mir-8084 Prostatic Neoplasms DISCUSSION: Our results suggested that determined common hsa-miR3p, hsa-miR-3128, hsa-miR-8084 and their target HIF1A, AVRP1A, NHS, INSL4 may play a crucial role in therapeutic and early diagnostic strategies for prostate cancer. +lncRNA target 36326314 hsa-mir-494 Prostatic Neoplasms DISCUSSION: Our results suggested that determined common hsa-miR3p, hsa-miR-3128, hsa-miR-8084 and their target HIF1A, AVRP1A, NHS, INSL4 may play a crucial role in therapeutic and early diagnostic strategies for prostate cancer. +lncRNA target 36326314 hsa-mir-494 Prostatic Hyperplasia DISCUSSION: Our results suggested that determined common hsa-miR3p, hsa-miR-3128, hsa-miR-8084 and their target HIF1A, AVRP1A, NHS, INSL4 may play a crucial role in therapeutic and early diagnostic strategies for prostate cancer. +lncRNA target 36326314 hsa-mir-128 Prostatic Neoplasms DISCUSSION: Our results suggested that determined common hsa-miR3p, hsa-miR-3128, hsa-miR-8084 and their target HIF1A, AVRP1A, NHS, INSL4 may play a crucial role in therapeutic and early diagnostic strategies for prostate cancer. +lncRNA target 36326096 hsa-mir-873 Esophageal Squamous Cell Carcinoma In conclusion, UCA1 can protect Human Umbilical Vein Endothelial Cells from ox-LDL-induced injury via the miR5p/MAPK8 axis. +exosome 36325775 hsa-mir-204 Myocardial Reperfusion Injury Results hUC-MSCs had adipogenic and osteogenic differentiation capabilities,and the exosomes were successfully identified.Compared with the negative control group,the miR-204 mimic group showed up-regulated expression of miR-204 in hUC-MSCs and their exosomes(P<0.001,P<0.001).Compared with the sham operation group,the modeling of I/R increased the left ventricular end-diastolic diameter(LVEDD)(P<0.001),left ventricular end-systolic diameter(LVESD)(P<0.001),myocardial injury score(P<0.001),and the levels of IL-1beta(P<0.001),TNF-alpha(P<0.001),and CD11c(P<0.001).Meanwhile,it lowered the left ventricular ejection fraction(LVEF)(P<0.001),left ventricular fractional shortening(LVFS)(P<0.001),Arg-1(P<0.001),IL-10(P<0 CD206(P<0.001).Compared with those in the I/R group,the LVEDD(P<0.001),LVESD(P<0.001),myocardial injury score(P<0.001),and the levels of IL-1beta(P<0.001),TNF-alpha(P=0.010),and CD11c(P<0.001) reduced,while LVEF(P<0.001),LVFS(P<0.001),and the levels of Arg-1(P<0.001),IL-10(P=0.028),and CD206(P=0.022) increased in the hUC-MSC exosomes group.Compared with those in the negative control group,the LVEDD(P<0.001),LVESD(P<0.001),myocardial injury score(P=0.001),and the levels of IL-1beta(P=0.048),TNF-alpha(P<0.001),and CD11c(P=0.007) reduced,while the LVEF(P<0.001),LVFS(P<0.001),and the levels of Arg-1(P<0.001),IL-10(P=0.001),and CD206(P=0.001) increased in the miR-204 mimic group. +other 36325355 hsa-mir-181c Leukemia, Lymphocytic, Chronic, B-Cell We identified 6 groups of patients with a distinct probability of being CR with BM uMRD to FCR treatment, ranging from 72% (miR-125b, miR-15b and miR-181c high) to 4% (miR-125b and miR-193b low). +other 36325355 hsa-mir-125b Leukemia, Lymphocytic, Chronic, B-Cell We identified 6 groups of patients with a distinct probability of being CR with BM uMRD to FCR treatment, ranging from 72% (miR-125b, miR-15b and miR-181c high) to 4% (miR-125b and miR-193b low). +other 36325355 hsa-mir-15b Leukemia, Lymphocytic, Chronic, B-Cell We identified 6 groups of patients with a distinct probability of being CR with BM uMRD to FCR treatment, ranging from 72% (miR-125b, miR-15b and miR-181c high) to 4% (miR-125b and miR-193b low). +other 36325355 hsa-mir-193b Leukemia, Lymphocytic, Chronic, B-Cell We identified 6 groups of patients with a distinct probability of being CR with BM uMRD to FCR treatment, ranging from 72% (miR-125b, miR-15b and miR-181c high) to 4% (miR-125b and miR-193b low). +transcription factor target 36324898 hsa-mir-532 Colorectal Neoplasms 3p/si-KRAS might provide a promising potential strategy for inhibiting the malignant phenotypes of CRC cells. +transcription factor target 36324569 hsa-mir-140 Colorectal Neoplasms Our results, both in vitro and in vivo, suggest that miR-140 may act as a tumor suppressor and plays an important role in DSB DNA repair and, consequently, CRC therapy response. +other 36324503 hsa-mir-23a Multiple Sclerosis 3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found. +other 36324503 hsa-mir-29c Multiple Sclerosis 3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found. +other 36324503 hsa-mir-29b Multiple Sclerosis 3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found. +other 36324503 hsa-mir-200a Multiple Sclerosis 3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found. +other 36324503 hsa-mir-145 Multiple Sclerosis 3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found. +other 36324503 hsa-mir-22 Multiple Sclerosis 3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found. +other 36324503 hsa-mir-20a Multiple Sclerosis 3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found. +other 36324503 hsa-mir-34a Multiple Sclerosis 3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found. +other 36324503 hsa-mir-27a Multiple Sclerosis 3p, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-34a-5p) were found. +transcription factor target 36324256 hsa-mir-101 Pre-Eclampsia 3p in placenta contributes to the development of PE by suppressing WDR5-mediated proliferation and invasion of trophoblast. +lncRNA target 36322830 hsa-mir-372 hereditary diffuse gastric cancer Mining of this dataset across the human transcriptome defined a drug-like fragment that potently and specifically targeted the microRNA-372 hairpin precursor, inhibiting its processing into the mature, functional microRNA and alleviating invasive and proliferative oncogenic phenotypes in gastric cancer cells. +other 36322827 hsa-mir-148a Leukemia, Myeloid miR-148a-3p and DDX6 functional link promotes survival of myeloid leukemia cells. +other 36322719 hsa-mir-29a Neovascularization, Pathologic Our data suggest that miR-29a may be a promising clinical candidate for the treatment of neovascular diseases. +other 36322706 hsa-mir-125a Brain Ischemia RESULTS: CircSTK39 and ERCC6 expression were significantly downregulated, but miR-125a-5p expression was upregulated in the lens tissues of ARC patients and H(2)O(2)-treated SRA01/04 cells. +genetics_knock down_promote 36322370 hsa-mir-340 Spinal Cord Injuries Knockdown of miR-340 or overexpression of NEK7 reversed the suppressive effects of SAHA on microglia inflammation and pyroptosis. +genetics_knock down_promote 36322370 hsa-mir-340 Subarachnoid Hemorrhage Knockdown of miR-340 or overexpression of NEK7 reversed the suppressive effects of SAHA on microglia inflammation and pyroptosis. +circulation_biomarker_diagnosis_down 36322282 hsa-mir-29a Graves Disease Collectively, our results demonstrate that miR-29a-3p emerges as a post-transcriptional brake to limit circulating Tfh memory cell response in GD patients and may be involved in the pathogenesis of GD. +other 36321868 hsa-mir-495 Squamous Cell Carcinoma of Head and Neck Hsa-miR3p is closely related to the diagnosis and prognosis of OSCC. +other 36321868 hsa-mir-495 Periodontitis Hsa-miR3p is closely related to the diagnosis and prognosis of OSCC. +other 36321836 hsa-mir-155 Esophageal Squamous Cell Carcinoma MIR155HG encodes a precursor RNA of microRNA-155 (miRNA-155). +transcription factor target 36321792 hsa-mir-221 Precursor Cell Lymphoblastic Leukemia-Lymphoma Moreover, changes were observed in the expression of CDKN1B, a known target of miR +transcription factor target 36321792 hsa-mir-222 Precursor Cell Lymphoblastic Leukemia-Lymphoma Moreover, changes were observed in the expression of CDKN1B, a known target of miR +lncRNA target 36321407 hsa-mir-181c Colorectal Neoplasms To be concluded, SPR inactivates PI3K/AKT signaling pathway to suppress CRC cell proliferation, invasion, and migration via miR-181c/d-5p/RBM47. +exosome 36321189 hsa-mir-106 Prostatitis, Chronic In CP/CPPS, urine exosomes exhibited significant upregulation of eight PCa-specific microRNAs (e.g., hsa-miR-501, hsa-miR-20a, and hsa-miR-106), whose target genes were significantly enriched for GO terms, hallmark gene sets, and pathways specific for carcinogenesis. +exosome 36321189 hsa-mir-501 Prostatitis, Chronic In CP/CPPS, urine exosomes exhibited significant upregulation of eight PCa-specific microRNAs (e.g., hsa-miR-501, hsa-miR-20a, and hsa-miR-106), whose target genes were significantly enriched for GO terms, hallmark gene sets, and pathways specific for carcinogenesis. +exosome 36321189 hsa-mir-20a Prostatitis, Chronic In CP/CPPS, urine exosomes exhibited significant upregulation of eight PCa-specific microRNAs (e.g., hsa-miR-501, hsa-miR-20a, and hsa-miR-106), whose target genes were significantly enriched for GO terms, hallmark gene sets, and pathways specific for carcinogenesis. +exosome 36321189 hsa-mir-20a Chronic Pelvic Pain Syndrome In CP/CPPS, urine exosomes exhibited significant upregulation of eight PCa-specific microRNAs (e.g., hsa-miR-501, hsa-miR-20a, and hsa-miR-106), whose target genes were significantly enriched for GO terms, hallmark gene sets, and pathways specific for carcinogenesis. +exosome 36321189 hsa-mir-106 Chronic Pelvic Pain Syndrome In CP/CPPS, urine exosomes exhibited significant upregulation of eight PCa-specific microRNAs (e.g., hsa-miR-501, hsa-miR-20a, and hsa-miR-106), whose target genes were significantly enriched for GO terms, hallmark gene sets, and pathways specific for carcinogenesis. +exosome 36321189 hsa-mir-501 Chronic Pelvic Pain Syndrome In CP/CPPS, urine exosomes exhibited significant upregulation of eight PCa-specific microRNAs (e.g., hsa-miR-501, hsa-miR-20a, and hsa-miR-106), whose target genes were significantly enriched for GO terms, hallmark gene sets, and pathways specific for carcinogenesis. +genetics_GWAS 36320325 hsa-mir-145 Urinary Bladder Neoplasms MIR145 core promoter methylation was identified as a potent epigenetic regulator of miR-143/145 cluster, supporting modern personalized risk stratification and management in BlCa. +genetics_GWAS 36320325 hsa-mir-143 Urinary Bladder Neoplasms MIR145 core promoter methylation was identified as a potent epigenetic regulator of miR-143/145 cluster, supporting modern personalized risk stratification and management in BlCa. +lncRNA target 36320323 hsa-mir-196a Huntington Disease Taken together, miR-196a enhances polymerization of neuronal microfilaments through suppressing IMP3 and upregulating IGF2 in HD, supporting the neuroprotective functions of miR-196a through neuronal cytoskeleton in HD. +exosome 36319884 hsa-mir-222 AIDS-Related Complex Exosomal miR +other 36319782 hsa-mir-10 Multiple Sclerosis CONCLUSION: The change in miR-10, miR-124, and miR-21 expression patterns was implied to participate in MS development. +other 36319782 hsa-mir-21 Multiple Sclerosis CONCLUSION: The change in miR-10, miR-124, and miR-21 expression patterns was implied to participate in MS development. +other 36319782 hsa-mir-124 Multiple Sclerosis CONCLUSION: The change in miR-10, miR-124, and miR-21 expression patterns was implied to participate in MS development. +exosome 36319622 hsa-mir-181d Carcinoma, Renal Cell Further investigation revealed that CAFs could enhance cancer stemness through delivering exosomes to RCC cells, and miR-181d-5p was identified as the critical exosomal miRNA in CAF-secreted exosomes by small RNA sequencing and subsequent screening assays. Mechanistically, exosomal miR-181d-5p transferred from CAFs to RCC cells directly suppressed the expression of ring finger protein 43 (RNF43) and activated Wnt/beta-catenin signaling pathway, thus promoted cancer stemness and tumor progression. +other 36319098 hsa-mir-196b Essential Hypertension 3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group. +other 36319098 hsa-mir-874 Essential Hypertension 3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group. +other 36319098 hsa-mir-296 Essential Hypertension 3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group. +other 36319098 hsa-mir-503 Essential Hypertension 3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group. +other 36319098 hsa-mir-150 Essential Hypertension 3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group. +other 36319098 hsa-mir-100 Essential Hypertension 3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group. +other 36319098 hsa-mir-940 Essential Hypertension 3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group. +other 36319098 hsa-mir-543 Essential Hypertension 3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group. +other 36319098 hsa-mir-628 Essential Hypertension 3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group. +other 36319098 hsa-mir-299 Essential Hypertension 3p and hsa-miR-940 was down-regulated in the hypertension group compared with the control group. +lncRNA target 36319097 hsa-mir-155 Pulmonary Disease, Chronic Obstructive These results suggest that miR-155 activates the PTEN/PI3K/Akt signaling pathway by targeting PIK3R1 to promote the occurrence and development of COPD, which provides new evidence for the use of miR-155 in the treatment of COPD. +other 36319063 hsa-mir-125b Colonic Neoplasms Furthermore, in human colon adenocarcinoma patients, we verified that miR-125b-5p expression was downregulated, and low levels of miR-125b-5p were associated with poor prognosis. +other 36318963 hsa-mir-29a Alzheimer Disease In particular, miRNA-29 represents a class of miRNAs known to regulate pathogenesis of AD. +other 36318963 hsa-mir-29 Alzheimer Disease In particular, miRNA-29 represents a class of miRNAs known to regulate pathogenesis of AD. +other 36317581 hsa-mir-1 Squamous Cell Carcinoma of Head and Neck This method has been successfully applied to detect and identify miR-21 and miR-31 in saliva from oral squamous cell carcinoma (OSCC) patients and healthy subjects. +other 36317581 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck This method has been successfully applied to detect and identify miR-21 and miR-31 in saliva from oral squamous cell carcinoma (OSCC) patients and healthy subjects. +genetics_knock down_promote 36317454 hsa-mir-138 Colorectal Neoplasms 5p was downregulated in CRC and its knockdown accelerated CRC progression. +target gene 36317339 hsa-mir-181a Stomach Neoplasms TCL1A acts as a tumour suppressor by modulating gastric cancer autophagy via miR-181a-5p-TCL1A-Akt/mTOR-c-MYC loop. +genetics_GWAS 36317205 hsa-mir-146 Primary Ovarian Insufficiency RESULTS: Compared with control group, the expression level of miRNA-146 in POI group was significantly lower, the expression level of OX-LDL and ROS were significantly higher, and the ovarian volume and peak systolic blood flow velocity of ovarian artery were significantly decreased in POI group. +other 36316703 hsa-mir-29b Colorectal Neoplasms Functional assays revealed that LIFR-AS1 could competitively bind to hsa-miR-29b-3p, and repressed colon cancer cell proliferation, colony formation and invasion. +circRNA target 36316592 hsa-mir-185 Diabetic Nephropathies Circ_0008529 might be a potential target for DN, which regulated DN progression via miR5p/SMAD2 pathway. +lncRNA target 36316351 hsa-mir-34c Stomach Neoplasms Accordingly, our results support that E2F1 is an engaging target of drug development in tumor growth and aggressive proliferation of GC, and favorable results can be achieved through tumor suppressor lncRNA GAS5/miR-34c axis in GC. +other 36316110 hsa-mir-23b Stomach Neoplasms Moreover, low miR-23b expression predicted longer 10-year survival (P=0.0066) in patients with GC. MiR-23b-5p expression status could serve as a prognostic marker for survival in patients with GC. +circRNA target 36315981 hsa-mir-587 Uterine Cervical Neoplasms CONCLUSION: Circ_0031027 inhibited the enlargement of CC by miR-587/SOCS5. +lncRNA target 36315357 hsa-mir-29b Cardiomyopathies Overall, our findings imply that induction of miR-29b-3p, which negatively regulates GSK-3beta and BMF expression, attenuates CME-induced myocardial injury, suggesting a novel potential therapeutic target for cardioprotective after CME. +circRNA target 36315192 hsa-mir-190a Reperfusion Injury, Renal Ischemia Finally, inhibition of circRNA_45478 significantly alleviated the progression of ischemic AKI through regulation of the miR-190a-5p/PHLPP1 pathway. Taken together, our data showed that circRNA_45478/miR-190a-5p/PHLPP1 axis mediated the progression of ischemic AKI. +genetics_overexpression_promote 36314369 hsa-mir-92a Uterine Cervical Neoplasms Functional rescue assays revealed that miR-92a-3p overexpression or BTG2 downregulation reversed the inhibitory role of CARMN overexpression in CC cell growth. +circRNA target 36314002 hsa-mir-370 FG syndrome CONCLUSION: The hsa-circ-0005238 modulates FGR pathogenesis by inhibiting trophoblast cell invasion and migration through sponging hsa-miR3p. +lncRNA target 36313765 hsa-mir-34a Uterine Cervical Neoplasms A pair of ceRNAs (CA9/ULBP2) could be involved in the carcinogenesis and development of cervical cancer, and the potential target might be hsa-miR-34a. Further research found that the ceRNA pairs of ULBP2/CA9 could regulate cervical cancer through hsa-miR-34a. +circRNA target 36313671 hsa-mir-361 Colonic Neoplasms CircHADHA increased the expression of ATG13 via miR-361 in both colon epithelial and cancer cells. CircHADHA promoted autophagy by regulating ATG13 via miR-361 in both colon epithelial and cancer cells. +genetics_knock down_suppress 36313631 hsa-let-7g Gallbladder Neoplasms The loss of let-7g-5p enhanced the expression of IGF2BP3 and improved GBC progression. +target gene 36313626 hsa-mir-1 Breast Neoplasms The antihyperlipidemic drug potassium piperonate impairs the migration and tumorigenesis of breast cancer cells via the upregulation of miR-31. +other 36313468 hsa-mir-103a Colorectal Neoplasms In addition, we predict that hsa-miR-103a could be a potential biomarker of colon cancer and hsa-mir-193b and hsa-mir-7days could be potential biomarkers of colorectal cancer. +other 36313468 hsa-mir-193b Colorectal Neoplasms In addition, we predict that hsa-miR-103a could be a potential biomarker of colon cancer and hsa-mir-193b and hsa-mir-7days could be potential biomarkers of colorectal cancer. +other 36313468 hsa-mir-103a Colonic Neoplasms In addition, we predict that hsa-miR-103a could be a potential biomarker of colon cancer and hsa-mir-193b and hsa-mir-7days could be potential biomarkers of colorectal cancer. +other 36313468 hsa-mir-193b Colonic Neoplasms In addition, we predict that hsa-miR-103a could be a potential biomarker of colon cancer and hsa-mir-193b and hsa-mir-7days could be potential biomarkers of colorectal cancer. +circulation_biomarker_diagnosis_up 36313425 hsa-mir-486 Aortic Valve Insufficiency The expression of serum EV miRNAs (up-regulated: miR-223 and let-7e-5p and miR +circulation_biomarker_diagnosis_up 36313425 hsa-let-7e Aortic Valve Insufficiency The expression of serum EV miRNAs (up-regulated: miR-223 and let-7e-5p and miR +circulation_biomarker_diagnosis_up 36313425 hsa-mir-223 Aortic Valve Insufficiency The expression of serum EV miRNAs (up-regulated: miR-223 and let-7e-5p and miR +circulation_biomarker_diagnosis_up 36313425 hsa-mir-152 Aortic Valve Insufficiency The expression of serum EV miRNAs (up-regulated: miR-223 and let-7e-5p and miR +circulation_biomarker_diagnosis_up 36313425 hsa-mir-199a Aortic Valve Insufficiency The expression of serum EV miRNAs (up-regulated: miR-223 and let-7e-5p and miR +circulation_biomarker_diagnosis_up 36313425 hsa-mir-148a Aortic Valve Insufficiency The expression of serum EV miRNAs (up-regulated: miR-223 and let-7e-5p and miR +other 36313069 hsa-mir-642a Obesity In bEVs of mothers with obesity, 19 miRNAs were differentially expressed (adjusted p < 0.05 cut-off), which include miR-575, miR-630, miR-642a-3p, and miR5p. +other 36313069 hsa-mir-652 Obesity In bEVs of mothers with obesity, 19 miRNAs were differentially expressed (adjusted p < 0.05 cut-off), which include miR-575, miR-630, miR-642a-3p, and miR5p. +other 36313069 hsa-mir-630 Obesity In bEVs of mothers with obesity, 19 miRNAs were differentially expressed (adjusted p < 0.05 cut-off), which include miR-575, miR-630, miR-642a-3p, and miR5p. +other 36312756 hsa-mir-129-2 Breast Neoplasms Furthermore, the expression of miR2-3p in breast cancer patients was about twice that in healthy people. +lncRNA target 36312597 hsa-mir-22a Hypertension, Pulmonary "In WGCNA, gene modules significantly related to PAH, CPH, and INCPH were identified, and enrichment function analysis showed that the common pathway of PAH and CPH were ""P53 signaling pathway,"" ""synthesis of neutral lipids""; PAH and INCPH are ""terminal,"" ""Maintenance Regulation of Granules,"" and ""Toxin Transport."" DEGs confirmed the results of WGCNA; the common miRNA functions of PAH and cirrhosis were enriched for ""P53 signaling pathway,"" ""TGF-beta signaling pathway,"" ""TNF signaling pathway,"" and ""fatty acid metabolism,"" and the miRNAs-mRNAs network suggested that hsa-miR-22a-3p regulates MDM2 and hsa-miR-34a-5p regulates PRDX4; the target genes of PAH and INCPH are EIF5B, HSPA4, GNL3, RARS, UTP20, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and their target miRNA function enrichment showed EIF5B, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and HSPA4 are associated with telomeres and inflammation, panglaoDB showed that target genes are located in endothelial cells, smooth muscle cells, etc." +lncRNA target 36312597 hsa-mir-22a Hypertension, Portal "In WGCNA, gene modules significantly related to PAH, CPH, and INCPH were identified, and enrichment function analysis showed that the common pathway of PAH and CPH were ""P53 signaling pathway,"" ""synthesis of neutral lipids""; PAH and INCPH are ""terminal,"" ""Maintenance Regulation of Granules,"" and ""Toxin Transport."" DEGs confirmed the results of WGCNA; the common miRNA functions of PAH and cirrhosis were enriched for ""P53 signaling pathway,"" ""TGF-beta signaling pathway,"" ""TNF signaling pathway,"" and ""fatty acid metabolism,"" and the miRNAs-mRNAs network suggested that hsa-miR-22a-3p regulates MDM2 and hsa-miR-34a-5p regulates PRDX4; the target genes of PAH and INCPH are EIF5B, HSPA4, GNL3, RARS, UTP20, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and their target miRNA function enrichment showed EIF5B, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and HSPA4 are associated with telomeres and inflammation, panglaoDB showed that target genes are located in endothelial cells, smooth muscle cells, etc." +lncRNA target 36312597 hsa-mir-34a Hypertension, Portal "In WGCNA, gene modules significantly related to PAH, CPH, and INCPH were identified, and enrichment function analysis showed that the common pathway of PAH and CPH were ""P53 signaling pathway,"" ""synthesis of neutral lipids""; PAH and INCPH are ""terminal,"" ""Maintenance Regulation of Granules,"" and ""Toxin Transport."" DEGs confirmed the results of WGCNA; the common miRNA functions of PAH and cirrhosis were enriched for ""P53 signaling pathway,"" ""TGF-beta signaling pathway,"" ""TNF signaling pathway,"" and ""fatty acid metabolism,"" and the miRNAs-mRNAs network suggested that hsa-miR-22a-3p regulates MDM2 and hsa-miR-34a-5p regulates PRDX4; the target genes of PAH and INCPH are EIF5B, HSPA4, GNL3, RARS, UTP20, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and their target miRNA function enrichment showed EIF5B, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and HSPA4 are associated with telomeres and inflammation, panglaoDB showed that target genes are located in endothelial cells, smooth muscle cells, etc." +lncRNA target 36312597 hsa-mir-34a Hypertension, Pulmonary "In WGCNA, gene modules significantly related to PAH, CPH, and INCPH were identified, and enrichment function analysis showed that the common pathway of PAH and CPH were ""P53 signaling pathway,"" ""synthesis of neutral lipids""; PAH and INCPH are ""terminal,"" ""Maintenance Regulation of Granules,"" and ""Toxin Transport."" DEGs confirmed the results of WGCNA; the common miRNA functions of PAH and cirrhosis were enriched for ""P53 signaling pathway,"" ""TGF-beta signaling pathway,"" ""TNF signaling pathway,"" and ""fatty acid metabolism,"" and the miRNAs-mRNAs network suggested that hsa-miR-22a-3p regulates MDM2 and hsa-miR-34a-5p regulates PRDX4; the target genes of PAH and INCPH are EIF5B, HSPA4, GNL3, RARS, UTP20, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and their target miRNA function enrichment showed EIF5B, HNRNPA2B1, HSP90B1, METAP2, NARS, SACM1L, and HSPA4 are associated with telomeres and inflammation, panglaoDB showed that target genes are located in endothelial cells, smooth muscle cells, etc." +other 36312586 hsa-mir-92b Breast Neoplasms Moreover, we identified the lncRNA XIST/miR-92b-3p/MTF1 regulatory axis for breast cancer. We discovered the lncRNA XIST/miR-92b-3p/MTF1 regulatory axis for breast cancer, which has not yet been investigated previously. +other 36312469 hsa-mir-139 Carcinoma, Hepatocellular The SNHG3/THUMP3-AS1-miR5p-SMARCA4 ceRNA network was established and could be assumed to serve as a stimulatory mechanism in HCC. +genetics_knock down_promote 36311891 hsa-mir-7 Carcinoma, Non-Small-Cell Lung 5p knockdown exerted the opposite effects. +exosome 36311808 hsa-mir-466 Heat Stroke CONCLUSIONS: We demonstrate the effect of microglial exosomal miR-466i-5p on neurons apoptosis and reveal potentially Bcl-2/caspase-3 pathway in heatstroke. +exosome 36311808 hsa-mir-466 Brain Injuries CONCLUSIONS: We demonstrate the effect of microglial exosomal miR-466i-5p on neurons apoptosis and reveal potentially Bcl-2/caspase-3 pathway in heatstroke. +other 36311688 hsa-mir-20b Prostatic Neoplasms miR-20b-5p is a novel biomarker for detecting prostate cancer. +lncRNA target 36311369 hsa-mir-21 Carcinoma, Renal Cell Eventually, two novel lncRNAs, AL162377.1 and AF111167.2, targeting the miR +other 36311195 hsa-mir-574 Esophageal Squamous Cell Carcinoma MiR-574-5p promotes cell proliferation by negatively regulating small C-terminal domain phosphatase 1 in esophageal squamous cell carcinoma. +other 36311189 hsa-mir-146a Drug Hypersensitivity Effects of crocin on T-bet/GATA-3 ratio, and miR-146a and miR-106a expression OBJECTIVES: Although various studies have revealed the beneficial effects of crocin (derived from saffron), such as anti-inflammatory, anti-cancer, antioxidant, and immune modulator, however, its exact mechanism is unknown. +other 36311189 hsa-mir-106a Drug Hypersensitivity Effects of crocin on T-bet/GATA-3 ratio, and miR-146a and miR-106a expression OBJECTIVES: Although various studies have revealed the beneficial effects of crocin (derived from saffron), such as anti-inflammatory, anti-cancer, antioxidant, and immune modulator, however, its exact mechanism is unknown. +other 36311189 hsa-mir-106a Inflammation Effects of crocin on T-bet/GATA-3 ratio, and miR-146a and miR-106a expression OBJECTIVES: Although various studies have revealed the beneficial effects of crocin (derived from saffron), such as anti-inflammatory, anti-cancer, antioxidant, and immune modulator, however, its exact mechanism is unknown. +other 36311189 hsa-mir-146a Inflammation Effects of crocin on T-bet/GATA-3 ratio, and miR-146a and miR-106a expression OBJECTIVES: Although various studies have revealed the beneficial effects of crocin (derived from saffron), such as anti-inflammatory, anti-cancer, antioxidant, and immune modulator, however, its exact mechanism is unknown. +other 36311149 hsa-mir-10a Oligospermia In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS. +other 36311149 hsa-mir-10b Infertility In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS. +other 36311149 hsa-mir-10b Asthenozoospermia In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS. +other 36311149 hsa-mir-135b Asthenozoospermia In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS. +other 36311149 hsa-mir-10a Asthenozoospermia In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS. +other 36311149 hsa-mir-135b Oligospermia In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS. +other 36311149 hsa-mir-135b Infertility In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS. +other 36311149 hsa-mir-10b Oligospermia In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS. +other 36311149 hsa-mir-135a Asthenozoospermia In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS. +other 36311149 hsa-mir-10a Infertility In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS. +other 36311149 hsa-mir-135a Infertility In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS. +other 36311149 hsa-mir-135a Oligospermia In this study, we chose the most miRNAs referred to in the previous study as a potential seminal fluid marker (miR-10a, miR-10b, miR-135a and miR-135b) to test them as potential infertility-related miRNAs markers (Asthenospermia AS, Oligospermia OS, Astheno-Oligospermia ASOS) in addition to health normal sperm NS. +target gene 36311048 hsa-mir-210 Inflammatory Osteolysis Our study suggests a promising potential for hypoxia-induced DPSC-sEV to treat in fl ammatory or infective osteolysis and identifies a novel role of miR3p in concurrently hindering osteoclastogenesis and macrophage inflammatory response by inhibiting NF-kB1 expression. +other 36310619 hsa-mir-342 Ulcerative Colitis 3p) and 3 hub genes (CD44, HIF1A, and MMP2) might play an important role in the development of UC. +other 36310619 hsa-mir-142 Ulcerative Colitis 3p) and 3 hub genes (CD44, HIF1A, and MMP2) might play an important role in the development of UC. +other 36310619 hsa-mir-199a Ulcerative Colitis 3p) and 3 hub genes (CD44, HIF1A, and MMP2) might play an important role in the development of UC. +circulation_biomarker_diagnosis_down 36310502 hsa-mir-196a Squamous Cell Carcinoma of Head and Neck Additionally, in both DDP-resistant and -sensitive lines, GAS5 showed a cytoplasmic distribution and downregulated miR-196a in OSCC tissues. +other 36310379 hsa-mir-222 Diabetes Mellitus Increased miR-222 levels are associated with metabolic syndrome, insulin resistance, and diabetes. +other 36310379 hsa-mir-222 Insulin Resistance Increased miR-222 levels are associated with metabolic syndrome, insulin resistance, and diabetes. +other 36310379 hsa-mir-222 Metabolic Diseases Increased miR-222 levels are associated with metabolic syndrome, insulin resistance, and diabetes. Altogether, miR-222 exerts a direct effect in metabolic pathways of 3T3-L1 adipocytes that are relevant to adipocyte function, limiting adipogenesis and insulin signaling pathways, offering a mechanistic explanation for its reported association with metabolic diseases. +genetics_overexpression_promote 36309967 hsa-mir-548k Breast Neoplasms In this study, the significant overexpression of miR-548k in breast cancer tissues compared to adjacent normal tissues was confirmed. +other 36309937 hsa-mir-29c Neurodegenerative Diseases Recent reports have suggested that abnormal miR-29c expression in hippocampus have been implicated in the pathophysiology of some neurodegenerative and neuropsychiatric diseases. +other 36309937 hsa-mir-29c Brain Diseases Therefore, miR-29c might be a potential therapeutic agent for TNF-alpha accumulation and toxicity-related brain diseases. +exosome 36309693 hsa-mir-655 Osteosarcoma LncRNA XIST from the bone marrow mesenchymal stem cell derived exosome promotes osteosarcoma growth and metastasis through miR-655/ACLY signal. +genetics_knock down_promote 36309620 hsa-mir-378a Carcinoma, Renal Cell The results of loss-of-function experiments showed that inhibition of TOB2 reversed the inhibitory roles of miR-378a-3p inhibitor on RCC progression. +transcription factor target 36309619 hsa-mir-27a Lung Neoplasms METHODS: We detect the expression of miR-27a after exposure to hypoxia conditions in lung cancer cells via qPCR. +target gene 36309571 hsa-mir-29a Rhabdomyosarcoma A GRIP-1-EZH2 switch binding to GATA-4 is linked to the genesis of rhabdomyosarcoma through miR-29a. +circulation_biomarker_diagnosis_up 36308704 hsa-mir-182 Parkinson Disease 5p delivered by plasma exosomes promotes sevoflurane-induced neuroinflammation and cognitive dysfunction in aged POCD rats by targeting BDNF and activating the NF-kappaB pathway. +transcription factor target 36308623 hsa-mir-106b Intervertebral Disc Degeneration Our findings demonstrate that targeting miR-106b-5p in intervertebral disc has therapeutic effects on IDD. +other 36308360 hsa-mir-182 Breast Neoplasms COCLUSION: Down regulation of FOXO3 and up regulation of miR-182 expression was associated with advanced breast cancer. +circulation_biomarker_diagnosis_ns 36307990 hsa-mir-542 Lupus Erythematosus, Systemic 5p expression positively correlated with the levels of polyamine synthetases in peripheral blood mononuclear cells of patients with SLE as well as disease severity. +virus_miRNA 36307872 ebv-mir-BART18 Colorectal Neoplasms BART18-3p Promotes Colorectal Cancer Progression by Targeting De Novo Lipogenesis +circulation_biomarker_diagnosis_up 36307470 hsa-mir-543 Osteoarthritis Specifically, miR-542 and miR-543 expression levels in the synovial tissue, synovial fluid, and serum were consistently higher in the OA group than in the unaffected group, suggesting that these miRNAs may be used as biomarkers for detecting canine OA. +circulation_biomarker_diagnosis_up 36307470 hsa-mir-542 Osteoarthritis Specifically, miR-542 and miR-543 expression levels in the synovial tissue, synovial fluid, and serum were consistently higher in the OA group than in the unaffected group, suggesting that these miRNAs may be used as biomarkers for detecting canine OA. +other 36307001 hsa-mir-195 Carcinoma, Hepatocellular Several studies found that miR-195 plays an unavoidable role in the regulation of cell proliferation, cycle and apoptosis in hepatocellular carcinoma (HCC). +circulation_biomarker_diagnosis_ns 36306116 hsa-mir-124 Parkinson Disease MATERIAL AND METHODS: The circHIPK3 and microRNA-124 (miR-124) expression in human serum and cerebral fluid was detected using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) in 92 PD patients and 95 controls. +genetics_knock down_suppress 36306049 hsa-mir-205 Norrie disease CONCLUSION: 1500026H17Rik knockdown alleviated HG-induced podocyte injuries, including apoptosis, fibrosis, oxidative stress and inflammation, by governing the miR5p/EGR1 pathway, thus involving in DN development. +genetics_knock down_suppress 36306049 hsa-mir-205 Fibrosis CONCLUSION: 1500026H17Rik knockdown alleviated HG-induced podocyte injuries, including apoptosis, fibrosis, oxidative stress and inflammation, by governing the miR5p/EGR1 pathway, thus involving in DN development. +genetics_knock down_suppress 36306049 hsa-mir-205 Inflammation CONCLUSION: 1500026H17Rik knockdown alleviated HG-induced podocyte injuries, including apoptosis, fibrosis, oxidative stress and inflammation, by governing the miR5p/EGR1 pathway, thus involving in DN development. +other 36306007 hsa-mir-27b Thyroid Neoplasms LINC01089 blocks malignant progression of thyroid cancer by binding miR-27b-3p to enhance the FBLN5 protein level. +genetics_knock down_suppress 36305971 hsa-mir-135b Protein-Losing Enteropathies Knockdown of BMPER or overexpression of miR-135b inhibited the osteogenic differentiation of CTS-induced ossification in PLL cells. +genetics_overexpression_suppress 36305754 hsa-mir-133a-2 Uterine Cervical Neoplasms The overexpression of hsa-mir-133a-2 significantly inhibits the proliferation and invasion of cervical cancer cells. +genetics_GWAS 36305672 hsa-mir-196a-2 Carcinoma, Non-Small-Cell Lung This nanodevice can detect miR-196a2T with an ultralow detection limit of 2.46 aM; distinguish rare miR-196a2 SNP with a selectivity factor of 0.001%; and even profile miR-196a2T in human tissues for nonsmall cell lung cancer (NSCLC) diagnosis, risk assessment, and cancer type prediction. +transcription factor target 36305548 hsa-mir-140 Breast Neoplasms 3p regulates the expression of USP36, which mediates ubiquitination and regulates the expression of PKM2, and regulates the malignant biological behavior of breast cancer through the energy metabolism process. +other 36305435 hsa-mir-206 Rhinitis, Allergic, Seasonal miR-181a and miR-125b can be candidate biomarkers for SAR, and miR-206 for NA-A and PAR. +other 36305435 hsa-mir-126 Rhinitis, Allergic, Seasonal The changes in the expressions of selected miRNAs (miR- 125b, miR-126, miR-133b, miR-181a, and miR-206) that were found related to the allergic diseases according to the literature were determined using quantitative polymerase chain reaction. +other 36305435 hsa-mir-206 Asthma miR-181a and miR-125b can be candidate biomarkers for SAR, and miR-206 for NA-A and PAR. +other 36305435 hsa-mir-125b Rhinitis, Allergic, Seasonal The changes in the expressions of selected miRNAs (miR- 125b, miR-126, miR-133b, miR-181a, and miR-206) that were found related to the allergic diseases according to the literature were determined using quantitative polymerase chain reaction. +other 36305435 hsa-mir-125b Asthma The changes in the expressions of selected miRNAs (miR- 125b, miR-126, miR-133b, miR-181a, and miR-206) that were found related to the allergic diseases according to the literature were determined using quantitative polymerase chain reaction. +other 36305435 hsa-mir-126 Asthma The changes in the expressions of selected miRNAs (miR- 125b, miR-126, miR-133b, miR-181a, and miR-206) that were found related to the allergic diseases according to the literature were determined using quantitative polymerase chain reaction. +other 36305435 hsa-mir-133b Asthma The changes in the expressions of selected miRNAs (miR- 125b, miR-126, miR-133b, miR-181a, and miR-206) that were found related to the allergic diseases according to the literature were determined using quantitative polymerase chain reaction. +other 36305435 hsa-mir-181a Asthma The changes in the expressions of selected miRNAs (miR- 125b, miR-126, miR-133b, miR-181a, and miR-206) that were found related to the allergic diseases according to the literature were determined using quantitative polymerase chain reaction. +other 36305435 hsa-mir-133b Rhinitis, Allergic, Seasonal The changes in the expressions of selected miRNAs (miR- 125b, miR-126, miR-133b, miR-181a, and miR-206) that were found related to the allergic diseases according to the literature were determined using quantitative polymerase chain reaction. +other 36305435 hsa-mir-181a Rhinitis, Allergic, Seasonal The changes in the expressions of selected miRNAs (miR- 125b, miR-126, miR-133b, miR-181a, and miR-206) that were found related to the allergic diseases according to the literature were determined using quantitative polymerase chain reaction. +genetics_knock down_suppress 36305147 hsa-mir-424 Breast Neoplasms 5p; LINC00473 knockdown impeded the growth, migration, invasion, and epithelial-mesenchymal transition of BC cells, while these effects were abolished by miR +other 36305048 hsa-mir-873 Stomach Neoplasms CONCLUSION: Our research showed that hsa_circ_0005529 promoted tumorigenic behavior in gastric cancer cells by adsorbing miR5p to modulate ZEB1 levels. +lncRNA target 36304947 hsa-mir-27a Tuberculosis RESULTS: Differential miRNA expression profiles were obtained, and miR-27a-3p and miR-30b-5p were highly expressed in patients with TB. CONCLUSION: Our study not only identified differentially expressed miRNAs between the TB and control groups but also revealed that miR-27a-3p and miR-30b-5p regulate proinflammatory cytokine secretion and macrophage differentiation through VDR in macrophages. +lncRNA target 36304901 hsa-mir-185 Short Stature, Idiopathic, Autosomal Finally, the authors revealed that the silencing of hsa_circ_0008870 induces low expression of MAPK1 by impairing the sponge action of miR3p, thereby inhibiting chondrocyte proliferation, hypertrophy, and endochondral ossification, which results in a short stature phenotype. +circulation_biomarker_diagnosis_up 36304469 hsa-mir-106a Lymphoproliferative Disorders Levels of miRs-17, 19, 106a, and 194 were reduced in the plasma and extracellular vesicles (EV) of EBV+ PTLD+ group compared to matched controls, with miRs-17 (p = 0.034; plasma), miRs-19 (p = 0.029; EV) and miR-106a (p = 0.007; plasma and EV) being significantly reduced. +circulation_biomarker_diagnosis_up 36304469 hsa-mir-194 Epstein-Barr Virus Infections Levels of miRs-17, 19, 106a, and 194 were reduced in the plasma and extracellular vesicles (EV) of EBV+ PTLD+ group compared to matched controls, with miRs-17 (p = 0.034; plasma), miRs-19 (p = 0.029; EV) and miR-106a (p = 0.007; plasma and EV) being significantly reduced. +circulation_biomarker_diagnosis_up 36304469 hsa-mir-17 Lymphoproliferative Disorders Levels of miRs-17, 19, 106a, and 194 were reduced in the plasma and extracellular vesicles (EV) of EBV+ PTLD+ group compared to matched controls, with miRs-17 (p = 0.034; plasma), miRs-19 (p = 0.029; EV) and miR-106a (p = 0.007; plasma and EV) being significantly reduced. +circulation_biomarker_diagnosis_up 36304469 hsa-mir-17 Epstein-Barr Virus Infections Levels of miRs-17, 19, 106a, and 194 were reduced in the plasma and extracellular vesicles (EV) of EBV+ PTLD+ group compared to matched controls, with miRs-17 (p = 0.034; plasma), miRs-19 (p = 0.029; EV) and miR-106a (p = 0.007; plasma and EV) being significantly reduced. +circulation_biomarker_diagnosis_up 36304469 hsa-mir-194 Lymphoproliferative Disorders Levels of miRs-17, 19, 106a, and 194 were reduced in the plasma and extracellular vesicles (EV) of EBV+ PTLD+ group compared to matched controls, with miRs-17 (p = 0.034; plasma), miRs-19 (p = 0.029; EV) and miR-106a (p = 0.007; plasma and EV) being significantly reduced. +circulation_biomarker_diagnosis_up 36304469 hsa-mir-106a Epstein-Barr Virus Infections Levels of miRs-17, 19, 106a, and 194 were reduced in the plasma and extracellular vesicles (EV) of EBV+ PTLD+ group compared to matched controls, with miRs-17 (p = 0.034; plasma), miRs-19 (p = 0.029; EV) and miR-106a (p = 0.007; plasma and EV) being significantly reduced. +other 36304467 hsa-mir-196a-1 Intestinal Diseases 3p, respectively, to play a regulatory role in the process of high-altitude hypoxia-induced intestinal injury. +genetics_knock down_suppress 36304135 hsa-mir-512 Adenocarcinoma of Lung Overexpression of HMGA1 could restore the inhibitory effects of miR +other 36303988 hsa-mir-34a Infertility However, when omitting cases of male infertility (n = 15), miR122-5p remained significant (p < 0.05), while miR-365a-3p and miR-34a-5p no longer differed; interestingly, however, miR1260a and mir93.3p became significant (p = 0.0087/0.02, respectively). +other 36303988 hsa-mir-122 Infertility However, when omitting cases of male infertility (n = 15), miR122-5p remained significant (p < 0.05), while miR-365a-3p and miR-34a-5p no longer differed; interestingly, however, miR1260a and mir93.3p became significant (p = 0.0087/0.02, respectively). +other 36303988 hsa-mir-1260a Infertility However, when omitting cases of male infertility (n = 15), miR122-5p remained significant (p < 0.05), while miR-365a-3p and miR-34a-5p no longer differed; interestingly, however, miR1260a and mir93.3p became significant (p = 0.0087/0.02, respectively). +other 36303988 hsa-mir-93 Infertility However, when omitting cases of male infertility (n = 15), miR122-5p remained significant (p < 0.05), while miR-365a-3p and miR-34a-5p no longer differed; interestingly, however, miR1260a and mir93.3p became significant (p = 0.0087/0.02, respectively). +lncRNA target 36303447 hsa-mir-433 Glioma 3p suppressed glioma malignant progression via inhibiting NR5A2. +lncRNA target 36303271 hsa-mir-21 Nasopharyngitis Collectively, EGF upregulates HIF-1alpha and miR-21 expression to inhibit AQP4 expression, thereby promoting the proliferation of nasal epithelial cells and the development of CRS. +transcription factor target 36303071 hsa-mir-29b Huntington Disease We observed age-associated alterations in chromatin accessibility between HD-MSNs and pre-HD-MSNs and identified miR-29b-3p, whose age-associated upregulation promotes HD-MSN degeneration by impairing autophagic function through human-specific targeting of the STAT3 3' untranslated region. Reducing miR-29b-3p or chemically promoting autophagy increased the resilience of HD-MSNs against neurodegeneration. +genetics_GWAS 36303006 hsa-mir-146a Arthritis, Rheumatoid The current research concludes that miRNA-146a (rs2910164; C > G) and miRNA-499 (rs3746444; T > C) polymorphisms are linked to RA in the population studied. +genetics_GWAS 36303006 hsa-mir-499 Arthritis, Rheumatoid The current research concludes that miRNA-146a (rs2910164; C > G) and miRNA-499 (rs3746444; T > C) polymorphisms are linked to RA in the population studied. +genetics_overexpression_promote 36302829 hsa-mir-181b Cardiomyopathies, Uremic In addition, miR-181b-5p overexpression exhibited same effects with ANRIL silencing in UC. +exosome 36302748 hsa-mir-592 Melanoma Thus, via the extracellular vesicle miR-592/PTPN7/MAPK axis, melanoma-CSCs can transfer their metastatic ability to the low-metastatic non-CSC melanoma cells. +transcription factor target 36302626 hsa-mir-23b Vascular Diseases These findings suggest that correcting the dysregulation of miR-23b/SMAD3 or lactate metabolism is a potential treatment for vascular diseases. +lncRNA target 36302471 hsa-mir-214 Pneumococcal Infections 5p and C1QTNF1 as potential novel targets for the treatment of PCV2 infection. +transcription factor target 36302396 hsa-mir-29a Abortion, Habitual Conclusion: MiR-29a may be involved in the pathogenesis of RSA by inhibiting the protein expressions of FKBP52 and VEGF, promoting the apoptosis of trophoblasts, and impairing neovascularization, resulting in placental vascular dysplasia.. +lncRNA target 36301978 hsa-mir-217 Urinary Bladder Neoplasms The present study suggested that FUS-medicated Circ_0002099 could promote the epithelial-mesenchymal transition process in BLCA progression via miR +lncRNA target 36301978 hsa-mir-103a Urinary Bladder Neoplasms The present study suggested that FUS-medicated Circ_0002099 could promote the epithelial-mesenchymal transition process in BLCA progression via miR +transcription factor target 36301034 hsa-mir-762 Lupus Vasculitis, Central Nervous System CONCLUSIONS: Upregulation of hub miRNA miR-762 can suppress the expression of GIPC3 in both SLE and NPSLE samples, which is probably involved in the development of SLE and NPSLE. +transcription factor target 36301034 hsa-mir-762 Lupus Erythematosus, Systemic CONCLUSIONS: Upregulation of hub miRNA miR-762 can suppress the expression of GIPC3 in both SLE and NPSLE samples, which is probably involved in the development of SLE and NPSLE. +lncRNA target 36301033 hsa-mir-582 Ataxia Neuropathy Spectrum The potential diagnostic and therapeutic strategies targeting miR +other 36301024 hsa-mir-506 Obesity CONCLUSIONS: The changes in the level of miR-506 and miR-124 in CRC patients may be associated with the regulatory role of these miRNAs on LAMC1 expression. +other 36301024 hsa-mir-124 Colorectal Neoplasms CONCLUSIONS: The changes in the level of miR-506 and miR-124 in CRC patients may be associated with the regulatory role of these miRNAs on LAMC1 expression. +other 36301024 hsa-mir-124 Obesity CONCLUSIONS: The changes in the level of miR-506 and miR-124 in CRC patients may be associated with the regulatory role of these miRNAs on LAMC1 expression. +other 36301024 hsa-mir-506 Colorectal Neoplasms CONCLUSIONS: The changes in the level of miR-506 and miR-124 in CRC patients may be associated with the regulatory role of these miRNAs on LAMC1 expression. +circulation_biomarker_diagnosis_up 36300679 hsa-mir-146a Peripartum Cardiomyopathy The myocardial up-regulation of the PPCM biomarkers plasminogen inhibitor activator 1 (PAI-1) and miR-146a were prevented by both cabergoline and bromocriptine therapy. +target gene 36300495 hsa-mir-541 Uterine Cervical Neoplasms Circ_0085616 contributes to the radio-resistance and progression of cervical cancer by targeting miR-541-3p/ARL2 signaling. +exosome 36299891 hsa-mir-222 Cardiomegaly 5p) or in EV-BMMSCs (miR +exosome 36299891 hsa-mir-146a Cardiomegaly 5p) or in EV-BMMSCs (miR +exosome 36299891 hsa-mir-221 Cardiomegaly 5p) or in EV-BMMSCs (miR +exosome 36299891 hsa-mir-124 Cardiomegaly 5p) or in EV-BMMSCs (miR +exosome 36299891 hsa-mir-181a Cardiomegaly 5p) or in EV-BMMSCs (miR +exosome 36299891 hsa-mir-126 Cardiomegaly 5p) or in EV-BMMSCs (miR +exosome 36299891 hsa-mir-93 Cardiomegaly 5p) or in EV-BMMSCs (miR +exosome 36299891 hsa-mir-21 Cardiomegaly 5p) or in EV-BMMSCs (miR +exosome 36299891 hsa-mir-181b Cardiomegaly 5p) or in EV-BMMSCs (miR +exosome 36299891 hsa-mir-143 Cardiomegaly 5p) or in EV-BMMSCs (miR +exosome 36299891 hsa-mir-210 Cardiomegaly 5p) or in EV-BMMSCs (miR +genetics_overexpression_promote 36299824 hsa-mir-452 Breast Neoplasms Additionally, RGS2 overexpression inhibited the malignant phenotypes of BC cells, but miR +target gene 36299503 hsa-mir-6867 Gallbladder Neoplasms HOXA-AS2 may affect the expression of YAP1 protein by regulating miR-6867, thereby inhibiting the Hippo signaling pathway and promoting the proliferation and metastasis of gallbladder cancer cells. +genetics_overexpression_promote 36299488 hsa-mir-512 Pre-Eclampsia 3p-overexpressing trophoblast and PE-associated placentas. +circulation_biomarker_diagnosis_ns 36299385 hsa-mir-21 Glioblastoma Expression of microRNAs miR-21 and miR-326 associated with HIF-1 regulation in BACKGROUND: Glioblastoma is an incurable neoplasm. The aim of this study was to identify a possible tumor malignancy signature associated with regulation of HIF-1 by microRNAs miR-21 and miR-326 in the subpopulation of tumor stem cells which were irradiated by ion in primary culture of patients diagnosed with glioblastoma. +circulation_biomarker_diagnosis_ns 36299385 hsa-mir-326 Glioblastoma Expression of microRNAs miR-21 and miR-326 associated with HIF-1 regulation in BACKGROUND: Glioblastoma is an incurable neoplasm. The aim of this study was to identify a possible tumor malignancy signature associated with regulation of HIF-1 by microRNAs miR-21 and miR-326 in the subpopulation of tumor stem cells which were irradiated by ion in primary culture of patients diagnosed with glioblastoma. +lncRNA target 36299340 hsa-mir-28 Chronic Periodontitis 5p may participate in CP progression by targeting SPHK1 to regulate the proliferation and inflammation of PDLCs. +genetics_knock down_suppress 36299308 hsa-mir-940 Periodontitis RESULTS: Higher abundance of circ_0099630 and TRAF6 and lower miR-940 expression were observed in periodontitis, and circ_0099630 knockdown attenuated the damage of human PDL cells (PDLCs) induced by lipopolysaccharides (LPS). CONCLUSION: Silencing circ_0099630 alleviates LPS-induced periodontal ligament cell injury via targeting miR-940/TRAF6/NF-kappaB in periodontitis. +genetics_overexpression_suppress 36298739 hsa-mir-155 Nervous Necrosis Virus Infectious Subsequently, it was proved that overexpression of cal-miR-155 enhanced cell apoptosis with or without NNV infection and inhibited virus replication in CAB cells. +target gene 36297369 hsa-mir-34a Liver Neoplasms Indole-3-Carbinol Stabilizes p53 to Induce miR-34a, Which Targets LDHA to Block Aerobic Glycolysis in Liver Cancer Cells. +circulation_biomarker_diagnosis_ns 36297290 hsa-mir-126 Diabetes Mellitus, Type 2 Our results revealed that HFD/STZ-induced T2D increased fasting blood glucose, ET-1, ICAM-1, E-selectin, and VIP levels, while decreasing the expression of both microRNA126-5p and p-AKT/p-Pi3k/p-PDK-1/p-mTOR phosphorylation. +transcription factor target 36296612 hsa-mir-145 Pituitary Diseases The study aimed to investigate whether the protective effects of LSW against endothelial dysfunction on vascular endothelial cells (VECs) was via vascular smooth muscle cells (VSMCs)-derived miRNA-145 packaged in EVs. +other 36295655 hsa-let-7e Breast Neoplasms 3p and let-7e-5p in breast cancer tissues with pathological response to neoadjuvant therapy (NAT) and clinicopathological data. +other 36295655 hsa-mir-375 Breast Neoplasms 3p and let-7e-5p in breast cancer tissues with pathological response to neoadjuvant therapy (NAT) and clinicopathological data. +other 36295655 hsa-mir-210 Breast Neoplasms 3p and let-7e-5p in breast cancer tissues with pathological response to neoadjuvant therapy (NAT) and clinicopathological data. +exosome 36295638 hsa-mir-10b Squamous Cell Carcinoma of Head and Neck Conclusions: Salivary exosomal miR-10b-5p and miR +exosome 36295638 hsa-mir-486 Squamous Cell Carcinoma of Head and Neck Conclusions: Salivary exosomal miR-10b-5p and miR +other 36295630 hsa-mir-609 Hemoglobin SC Disease miR-3609 and miR5p were most highly downregulated in sickle cell anemia with high HbF. +other 36295630 hsa-mir-483 Hemoglobin SC Disease miR-3609 and miR5p were most highly downregulated in sickle cell anemia with high HbF. +genetics_knock down_promote 36295086 hsa-mir-371a Carcinoma, Hepatocellular Moreover, gain- and loss-of-function assays and rescue assays were used to evaluate the mediated effect of BECN1-dependent autophagy on the role of miR-371a-5p in the response of HCC cells to OXA. +other 36295073 hsa-let-7 Colorectal Neoplasms Our results sustain the relationship between the IGF axis, let-7 miRNAs, and CRC and suggest an association between the expression of these miRNAs and perineural invasion. +other 36293469 hsa-mir-145 Retinoblastoma Levels of ADAM10 or ADAM17 regulating miRNAs miR-145, -152, and -365 were significantly downregulated in RB cell lines, and reduced miR levels with simultaneously upregulated ADAM10 and ADAM17 expression were found in RB patients. +other 36293268 hsa-mir-499 Severe Acute Respiratory Syndrome These results indicate that IH stress downregulates the miR-499 in cardiomyocytes, resulting in increased levels of Reg IV and Hgf mRNAs, leading to the protection of cardiomyocytes in SAS patients. +other 36293237 hsa-mir-34b Infertility, Male miR-34b and miR-34c were significantly associated with ICSI clinical outcomes in male factor infertility, especially teratozoospermia. +other 36293237 hsa-mir-34c Infertility, Male miR-34b and miR-34c were significantly associated with ICSI clinical outcomes in male factor infertility, especially teratozoospermia. +other 36293154 hsa-mir-182 Choriocarcinoma Transfecting a synthetic miR5p mimic decreased spheroid attachment of human JAr choriocarcinoma cells and E-cadherin expression (which is important for endometrial receptivity). +lncRNA target 36293154 hsa-mir-182 Embryo Loss The miR5p/NDRG1 Axis Controls Endometrial Receptivity through the Endometrial receptivity is essential for successful pregnancy, and its impairment is a major cause of embryo-implantation failure. +other 36293110 hsa-mir-20a Bronchiolitis Obliterans Syndrome 3p, and increased miR-20a-5p were the novel CAD-associated miRNAs in the TGF-beta pathway. +other 36293110 hsa-mir-101 Bronchiolitis Obliterans Syndrome 3p, and increased miR-20a-5p were the novel CAD-associated miRNAs in the TGF-beta pathway. +other 36293110 hsa-mir-21 Bronchiolitis Obliterans Syndrome 3p, and increased miR-20a-5p were the novel CAD-associated miRNAs in the TGF-beta pathway. +other 36292960 hsa-mir-126 Diabetic Nephropathies We found that during DN progression, miR145 and miR126 specifically increased in urinary EVs from diabetic patients together with albuminuria. This work highlights a modulation of miR126 and miR145 during the progression of kidney damage in diabetes as biomarkers of epithelial to mesenchymal transition. +other 36292960 hsa-mir-145 Diabetic Nephropathies We found that during DN progression, miR145 and miR126 specifically increased in urinary EVs from diabetic patients together with albuminuria. This work highlights a modulation of miR126 and miR145 during the progression of kidney damage in diabetes as biomarkers of epithelial to mesenchymal transition. +genetics_GWAS 36292185 hsa-mir-34b Thyroid Neoplasms To date, no study has been performed to evaluate the alterations of miRNA-146ars2910164 and miRNA34b/crs4938723 polymorphism as a risk factor in the development of thyroid cancer in the Pakistani population. Similarly in miRNA-34b/c gene SNP rs4938723 was observed to have a strong association with the development of thyroid cancer as the frequency of rare allele C was higher in patients. +circulation_biomarker_diagnosis_ns 36291965 hsa-mir-92a Diabetic Retinopathy 3p in the serum, with miR +circulation_biomarker_diagnosis_ns 36291965 hsa-mir-20a Diabetic Retinopathy 3p in the serum, with miR +circulation_biomarker_diagnosis_ns 36291965 hsa-mir-145 Diabetic Retinopathy 5p, and miR-145 in the serum and none in the vitreous samples. +circulation_biomarker_diagnosis_ns 36291965 hsa-mir-486 Diabetic Retinopathy 5p, and miR-145 in the serum and none in the vitreous samples. +circulation_biomarker_diagnosis_ns 36291965 hsa-mir-375 Diabetic Retinopathy 3p in the serum, with miR +circulation_biomarker_diagnosis_ns 36291965 hsa-mir-223 Diabetic Retinopathy 3p in the serum, with miR +transcription factor target 36291907 hsa-mir-181a Retinoblastoma We thus identified miR-181a-5p as a therapeutically exploitable target for EMT-triggered drug-resistant cancers that halted their invasion and migration and sensitized them to low-dose chemotherapy drugs. +lncRNA target 36291876 hsa-mir-214 Melanoma This finding points to miR-214 as a potential new therapeutic target to prevent melanoma intravasation. +other 36291859 hsa-mir-338 Adenocarcinoma of Lung 3p (upregulation)-MCM4 (downregulation) pattern significantly improved the overall survival of LUAD patients (p = 0.0093). +genetics_GWAS 36291816 hsa-mir-142 Lymphoma, Large B-Cell, Diffuse RESULTS: By proteome analyses, miR-142 knockout resulted in a consistent up-regulation of 52 but also down-regulation of 41 proteins in GC-DLBCL lines BJAB and SUDHL4. +other 36291575 hsa-mir-31 Prostatic Neoplasms RESULTS: hsa-mir3p and hsa-mir-200b were significantly reduced in prostate cancer patients compared to the control group. +other 36291575 hsa-mir-200b Prostatic Neoplasms RESULTS: hsa-mir3p and hsa-mir-200b were significantly reduced in prostate cancer patients compared to the control group. +transcription factor target 36291177 hsa-mir-147 Arthrogryposis and ectodermal dysplasia Mechanistically, structural proteins from ALV-J and REV synergistically activated the expression of Musashi-1(MSI1), which directly targeted pri-miR-147 through its RNA binding site. +transcription factor target 36291177 hsa-mir-147 Rolandic Epilepsy, Mental Retardation, and Speech Dyspraxia, X-Linked Mechanistically, structural proteins from ALV-J and REV synergistically activated the expression of Musashi-1(MSI1), which directly targeted pri-miR-147 through its RNA binding site. +transcription factor target 36291177 hsa-mir-147 Darier Disease Mechanistically, structural proteins from ALV-J and REV synergistically activated the expression of Musashi-1(MSI1), which directly targeted pri-miR-147 through its RNA binding site. +other 36291136 hsa-mir-155 Spinal Cord Injuries 5p can potentially influence pyroptosis and the occurrence and development of gout by affecting the expression of the PTGS2, CASP8, NFE2L2, and CD274 genes. +other 36291136 hsa-mir-155 Gout 5p can potentially influence pyroptosis and the occurrence and development of gout by affecting the expression of the PTGS2, CASP8, NFE2L2, and CD274 genes. +other 36291136 hsa-mir-20a Gout 5p can potentially influence pyroptosis and the occurrence and development of gout by affecting the expression of the PTGS2, CASP8, NFE2L2, and CD274 genes. +other 36291136 hsa-mir-128 Spinal Cord Injuries 5p can potentially influence pyroptosis and the occurrence and development of gout by affecting the expression of the PTGS2, CASP8, NFE2L2, and CD274 genes. +other 36291136 hsa-mir-16 Gout 5p can potentially influence pyroptosis and the occurrence and development of gout by affecting the expression of the PTGS2, CASP8, NFE2L2, and CD274 genes. +other 36291136 hsa-mir-128 Gout 5p can potentially influence pyroptosis and the occurrence and development of gout by affecting the expression of the PTGS2, CASP8, NFE2L2, and CD274 genes. +other 36291136 hsa-mir-16 Spinal Cord Injuries 5p can potentially influence pyroptosis and the occurrence and development of gout by affecting the expression of the PTGS2, CASP8, NFE2L2, and CD274 genes. +other 36291136 hsa-mir-20a Spinal Cord Injuries 5p can potentially influence pyroptosis and the occurrence and development of gout by affecting the expression of the PTGS2, CASP8, NFE2L2, and CD274 genes. +circulation_biomarker_diagnosis_ns 36290970 hsa-mir-133a-1 Carcinoma, Pancreatic Ductal From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC. +circulation_biomarker_diagnosis_ns 36290970 hsa-mir-425 Carcinoma, Pancreatic Ductal From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC. +circulation_biomarker_diagnosis_ns 36290970 hsa-mir-429 Carcinoma, Pancreatic Ductal From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC. +circulation_biomarker_diagnosis_ns 36290970 hsa-mir-30 Carcinoma, Pancreatic Ductal From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC. +circulation_biomarker_diagnosis_ns 36290970 hsa-mir-620 Carcinoma, Pancreatic Ductal From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC. +circulation_biomarker_diagnosis_ns 36290970 hsa-mir-1 Carcinoma, Pancreatic Ductal From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC. +circulation_biomarker_diagnosis_ns 36290970 hsa-mir-93 Carcinoma, Pancreatic Ductal From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC. +circulation_biomarker_diagnosis_ns 36290970 hsa-mir-210 Carcinoma, Pancreatic Ductal From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC. +circulation_biomarker_diagnosis_ns 36290970 hsa-mir-339 Carcinoma, Pancreatic Ductal From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC. +circulation_biomarker_diagnosis_ns 36290970 hsa-mir-1208 Carcinoma, Pancreatic Ductal From this analysis, 10 (MIR31, MIR93, MIR133A1, MIR210, MIR330, MIR339, MIR425, MIR429, MIR1208, and MIR3620) were chosen due to high copy number variation as well as their potential to differentiate patients with chronic pancreatitis, neoplasms, and PDAC. +other 36290936 hsa-mir-21 Osteosarcoma The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290. +other 36290936 hsa-mir-21 Pancreatic Diseases The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290. +other 36290936 hsa-mir-141 Pancreatic Diseases The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290. +other 36290936 hsa-mir-141 Osteosarcoma The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290. +other 36290936 hsa-mir-21 Prostatic Diseases The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290. +other 36290936 hsa-mir-141 Prostatic Diseases The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290. +other 36290936 hsa-mir-1290 Pancreatic Diseases The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290. +other 36290936 hsa-mir-1290 Prostatic Diseases The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290. +other 36290936 hsa-mir-1290 Osteosarcoma The Ho(2)O(3)-TiO(2) nanobelts showed a distinctly enhanced (004) reflection peak and rough surfaces and were used for the electrochemical selective sensing of various cancer miRNAs, such as prostate cancer miR-141, osteosarcoma miR-21, and pancreatic cancer miR-1290. +other 36290678 hsa-mir-4732 Cardiotoxicity Overall, the results indicate that miR3p is a novel biomarker of cardiotoxicity that has therapeutic potential against anthracycline-induced heart damage. +other 36290678 hsa-mir-4732 Breast Neoplasms Overall, the results indicate that miR3p is a novel biomarker of cardiotoxicity that has therapeutic potential against anthracycline-induced heart damage. +lncRNA target 36290402 hsa-mir-381 Endomyocardial Fibrosis 3p suppressed IMF deposition by inhibiting preadipocyte cell differentiation and lipid droplet deposition via the suppression of FABP3 expression in the peroxisome proliferator-activated receptor signalling pathway, whereas lncRNA4789 rescued FABP3 expression by sponging miR +target gene 36290289 hsa-mir-1275 Carcinoma, Hepatocellular Genistein Restricts the Epithelial Mesenchymal Transformation (EMT) and Stemness of Hepatocellular Carcinoma via Upregulating miR-1275 to Inhibit the EIF5A2/PI3K/Akt Pathway. +other 36289853 hsa-mir-16 Cardiovascular Diseases 3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR. +other 36289853 hsa-mir-24 Premature Birth 3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR. +other 36289853 hsa-mir-24 Cardiovascular Diseases 3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR. +other 36289853 hsa-mir-133a Premature Birth 3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR. +other 36289853 hsa-mir-210 Premature Birth 3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR. +other 36289853 hsa-mir-16 Premature Birth 3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR. +other 36289853 hsa-mir-21 Premature Birth 3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR. +other 36289853 hsa-mir-21 Cardiovascular Diseases 3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR. +other 36289853 hsa-mir-155 Premature Birth 3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR. +other 36289853 hsa-mir-155 Cardiovascular Diseases 3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR. +other 36289853 hsa-mir-210 Cardiovascular Diseases 3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR. +other 36289853 hsa-mir-133a Cardiovascular Diseases 3p; AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut-off > 0.652) could predict preterm delivery before 37 gestational weeks in early stages of gestation in 52.83% of pregnancies with a 10.0% FPR. +other 36289702 hsa-mir-124 Progeria 3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression. +other 36289702 hsa-mir-27b Osteoporosis 3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression. +other 36289702 hsa-mir-124 Osteoporosis 3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression. +other 36289702 hsa-mir-26a Progeria 3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression. +other 36289702 hsa-mir-27b Progeria 3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression. +other 36289702 hsa-mir-126 Progeria 3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression. +other 36289702 hsa-mir-26a Osteoporosis 3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression. +other 36289702 hsa-mir-126 Osteoporosis 3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression. +other 36289702 hsa-mir-181a Osteoporosis 3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression. +other 36289702 hsa-mir-181a Progeria 3p, and hsa-mir-27b-3p), (4) demonstrate the compatibility of well-established R packages for RNA-Seq analysis for researchers interested but not yet familiar with this kind of analysis, and (5) present comparative proteomics analyses to show an association between our RNA-Seq data analyses and corresponding changes in protein expression. +lncRNA target 36289686 hsa-let-7c Carcinoma, Renal Cell Transfection of ccRCC cells with pre-let-7c-5p significantly inhibited proliferation, migration, invasion, and IGF1R expression. +genetics_GWAS 36289656 hsa-mir-181a Abortion, Spontaneous This study investigated the genetic association between recurrent pregnancy loss (RPL) and microRNA (miRNA) polymorphisms in miR-10aA>T, miR-30cA>G, miR-181aT>C, and miR-499bA>G in Korean women. +genetics_GWAS 36289656 hsa-mir-10a Abortion, Spontaneous This study investigated the genetic association between recurrent pregnancy loss (RPL) and microRNA (miRNA) polymorphisms in miR-10aA>T, miR-30cA>G, miR-181aT>C, and miR-499bA>G in Korean women. +genetics_GWAS 36289656 hsa-mir-499 Abortion, Spontaneous This study investigated the genetic association between recurrent pregnancy loss (RPL) and microRNA (miRNA) polymorphisms in miR-10aA>T, miR-30cA>G, miR-181aT>C, and miR-499bA>G in Korean women. +genetics_GWAS 36289656 hsa-mir-499b Abortion, Spontaneous This study investigated the genetic association between recurrent pregnancy loss (RPL) and microRNA (miRNA) polymorphisms in miR-10aA>T, miR-30cA>G, miR-181aT>C, and miR-499bA>G in Korean women. +other 36289615 hsa-mir-184 Keratoconus miRNA analysis detected 16 altered species, including miR-184, responsible for familial severe keratoconus. +lncRNA target 36289596 hsa-mir-182 Lung Neoplasms 5p/ERO1A, GOLGA8B/miR-30d-5p/RUNX2, and PDCD6IPP2/miR-23a-3p/HOXA1) and the three tumor suppressive lncRNA-miRNA-mRNA regulatory axes (ANXA2P1/miR-20b-5p/FAM241A (C4orf32), MIR99AHG/miR +lncRNA target 36289596 hsa-mir-23a Lung Neoplasms 5p/ERO1A, GOLGA8B/miR-30d-5p/RUNX2, and PDCD6IPP2/miR-23a-3p/HOXA1) and the three tumor suppressive lncRNA-miRNA-mRNA regulatory axes (ANXA2P1/miR-20b-5p/FAM241A (C4orf32), MIR99AHG/miR +lncRNA target 36289596 hsa-mir-20b Lung Neoplasms 5p/ERO1A, GOLGA8B/miR-30d-5p/RUNX2, and PDCD6IPP2/miR-23a-3p/HOXA1) and the three tumor suppressive lncRNA-miRNA-mRNA regulatory axes (ANXA2P1/miR-20b-5p/FAM241A (C4orf32), MIR99AHG/miR +lncRNA target 36289596 hsa-mir-218 Lung Neoplasms 5p/ERO1A, GOLGA8B/miR-30d-5p/RUNX2, and PDCD6IPP2/miR-23a-3p/HOXA1) and the three tumor suppressive lncRNA-miRNA-mRNA regulatory axes (ANXA2P1/miR-20b-5p/FAM241A (C4orf32), MIR99AHG/miR +lncRNA target 36289596 hsa-mir-34a Lung Neoplasms 5p/ERO1A, GOLGA8B/miR-30d-5p/RUNX2, and PDCD6IPP2/miR-23a-3p/HOXA1) and the three tumor suppressive lncRNA-miRNA-mRNA regulatory axes (ANXA2P1/miR-20b-5p/FAM241A (C4orf32), MIR99AHG/miR +lncRNA target 36289596 hsa-mir-99a Lung Neoplasms 5p/ERO1A, GOLGA8B/miR-30d-5p/RUNX2, and PDCD6IPP2/miR-23a-3p/HOXA1) and the three tumor suppressive lncRNA-miRNA-mRNA regulatory axes (ANXA2P1/miR-20b-5p/FAM241A (C4orf32), MIR99AHG/miR +transcription factor target 36289489 hsa-mir-196b Acute Lung Injury CONCLUSIONS: Combination therapy with BUD and NAC ameliorates LPS-induced ALI by attenuating neutrophil recruitment through the miR-196b-5p/Socs3 molecular axis. +tissue_expression_ns 36289359 hsa-mir-4653 Carcinoma, Pancreatic Ductal 3p, decreased in the order-normal pancreatic duct, low-grade PanIN, high-grade PanIN, and PDAC. +other 36289253 hsa-mir-25 Brain Injuries 5p is a candidate treatment for septic encephalopathy. +other 36289253 hsa-mir-25 Sepsis-Associated Encephalopathy 5p is a candidate treatment for septic encephalopathy. +lncRNA target 36289101 hsa-mir-125a Hepatitis B, Chronic Mechanistically, HBV was able to directly induce the expression of miR-125a which inhibited the mRNA and protein levels of VDR. We conclude that inhibition of hepatic vitamin D receptor expression by HBV/miR-125a is negatively associated with liver inflammation and fibrosis in patients with chronic HBV infection. +lncRNA target 36289101 hsa-mir-125a Hepatitis Mechanistically, HBV was able to directly induce the expression of miR-125a which inhibited the mRNA and protein levels of VDR. We conclude that inhibition of hepatic vitamin D receptor expression by HBV/miR-125a is negatively associated with liver inflammation and fibrosis in patients with chronic HBV infection. +lncRNA target 36289101 hsa-mir-125a Diabetic Nephropathies Mechanistically, HBV was able to directly induce the expression of miR-125a which inhibited the mRNA and protein levels of VDR. We conclude that inhibition of hepatic vitamin D receptor expression by HBV/miR-125a is negatively associated with liver inflammation and fibrosis in patients with chronic HBV infection. +lncRNA target 36289041 hsa-mir-193a Breast Neoplasms The miR-193a-5p upregulation restrained chemoresistance and BC progression by the downregulation of Rap2A. CONCLUSION: All results unraveled that circ_0001667 contributed to ADM resistance and tumor development in BC via the miR-193a-5p-mediated Rap2A expression change, providing a novel regulatory mechanism for circ_0001667. +lncRNA target 36288952 hsa-mir-532 Colorectal Neoplasms 3p may serve as a potential target for treating colorectal carcinoma. +lncRNA target 36288764 hsa-mir-27a Infertility, Female CONCLUSION: These findings indicate a pro-survival mechanism of the MyoD/miR-27a-3p/Vangl1/Vangl2 axis for granulosa cell proliferation and suggest a novel target for the improvement of female fertility. +transcription factor target 36288761 hsa-mir-142 Uterine Cervical Neoplasms 5p acts as a tumor suppressor in cervical cancer. +lncRNA target 36288387 hsa-mir-3165 Urinary Bladder Neoplasms Additionally, miR-3165 inhibits METTL14 expression to promote BCa progression. In addition, miR-3165 down-regulates METTL14 expression to promote BCa progression. +lncRNA target 36287177 hsa-mir-141 Colonic Neoplasms Collectively, our findings suggest an important role of the Sohlh2/LncRNA-H19/miR-141/beta-catenin pathway in regulating colon CSC stemness and differentiation, suggesting potential therapeutic targets for colon cancer. +exosome 36287066 hsa-mir-216a Colitis CONCLUSIONS: Exosomal miR-216a-5p released from hypoxia-prime ASCs showed higher therapeutic efficiency than NExos in experimental colitis by promoting the M2 macrophage phenotype, which indicated that hypoxia prime may represent a promising approach to optimizing the function of ASC-derived exosomes. +genetics_knock down_promote 36286392 hsa-mir-562 Wilms Tumor CONCLUSION: Knockdown of hsa_circ_0093741 suppresses nephroblastoma cell growth, migration and invasion by regulating the miR-562/FRS2 axis, suggesting the potential involvement of hsa_circ_0093741 in nephroblastoma progression. +other 36286245 hsa-mir-198 Acquired Immunodeficiency Syndrome Activation of the DNA sensors in MDMs also induced the expression of the multiple intracellular anti-HIV factors, including IFN-stimulated genes (ISGs: ISG15, ISG56, Viperin, OAS2, GBP5, MxB, and Tetherin) and the HIV restriction microRNAs (miR-29c, miR-138, miR-146a, miR-155, miR-198, and miR-223). +other 36286245 hsa-mir-138 Acquired Immunodeficiency Syndrome Activation of the DNA sensors in MDMs also induced the expression of the multiple intracellular anti-HIV factors, including IFN-stimulated genes (ISGs: ISG15, ISG56, Viperin, OAS2, GBP5, MxB, and Tetherin) and the HIV restriction microRNAs (miR-29c, miR-138, miR-146a, miR-155, miR-198, and miR-223). +other 36286245 hsa-mir-155 Acquired Immunodeficiency Syndrome Activation of the DNA sensors in MDMs also induced the expression of the multiple intracellular anti-HIV factors, including IFN-stimulated genes (ISGs: ISG15, ISG56, Viperin, OAS2, GBP5, MxB, and Tetherin) and the HIV restriction microRNAs (miR-29c, miR-138, miR-146a, miR-155, miR-198, and miR-223). +other 36286245 hsa-mir-29c Acquired Immunodeficiency Syndrome Activation of the DNA sensors in MDMs also induced the expression of the multiple intracellular anti-HIV factors, including IFN-stimulated genes (ISGs: ISG15, ISG56, Viperin, OAS2, GBP5, MxB, and Tetherin) and the HIV restriction microRNAs (miR-29c, miR-138, miR-146a, miR-155, miR-198, and miR-223). +other 36286245 hsa-mir-223 Acquired Immunodeficiency Syndrome Activation of the DNA sensors in MDMs also induced the expression of the multiple intracellular anti-HIV factors, including IFN-stimulated genes (ISGs: ISG15, ISG56, Viperin, OAS2, GBP5, MxB, and Tetherin) and the HIV restriction microRNAs (miR-29c, miR-138, miR-146a, miR-155, miR-198, and miR-223). +other 36286245 hsa-mir-146a Acquired Immunodeficiency Syndrome Activation of the DNA sensors in MDMs also induced the expression of the multiple intracellular anti-HIV factors, including IFN-stimulated genes (ISGs: ISG15, ISG56, Viperin, OAS2, GBP5, MxB, and Tetherin) and the HIV restriction microRNAs (miR-29c, miR-138, miR-146a, miR-155, miR-198, and miR-223). +other 36286075 hsa-mir-885 Mast Cell Tumors This study aimed to validate the diagnostic potential of a panel of 3 miRNAs previously identified in canine mast cell tumors (MCTs), miR-21, miR-379, and miR-885, as markers of lymph node involvement in terms of histological absence (nonmetastatic: HN0; premetastatic: HN1) and presence (early-metastatic: HN2; overt-metastatic: HN3) of metastasis, in the saliva of mast cell tumor (MCT)-affected dogs by quantitative polymerase chain reaction (PCR). +genetics_GWAS 36286075 hsa-mir-21 Mast Cell Tumors Overall, salivary miR-21 was identified as a promising tool, representing a novel approach to detecting MCT-associated epigenetic alterations in a minimally invasive manner. +other 36286075 hsa-mir-379 Mast Cell Tumors This study aimed to validate the diagnostic potential of a panel of 3 miRNAs previously identified in canine mast cell tumors (MCTs), miR-21, miR-379, and miR-885, as markers of lymph node involvement in terms of histological absence (nonmetastatic: HN0; premetastatic: HN1) and presence (early-metastatic: HN2; overt-metastatic: HN3) of metastasis, in the saliva of mast cell tumor (MCT)-affected dogs by quantitative polymerase chain reaction (PCR). +circulation_biomarker_diagnosis_up 36286043 hsa-mir-122 Diabetes Mellitus, Type 2 5p in serum and the liver. +circulation_biomarker_diagnosis_up 36286043 hsa-mir-33a Diabetes Mellitus, Type 2 5p in serum and the liver. +circulation_biomarker_diagnosis_up 36286043 hsa-mir-21 Diabetes Mellitus, Type 2 5p in serum and the liver. +circulation_biomarker_diagnosis_up 36286043 hsa-mir-33a Atherosclerosis 5p in serum and the liver. +circulation_biomarker_diagnosis_up 36286043 hsa-mir-122 Atherosclerosis 5p in serum and the liver. +circulation_biomarker_diagnosis_up 36286043 hsa-mir-21 Atherosclerosis 5p in serum and the liver. +other 36286041 hsa-mir-146a Melanoma Human Melanoma Cells Differentially Express RNASEL/RNase-L and miR-146a-5p under Sex Hormonal Stimulation. +circulation_biomarker_diagnosis_ns 36286037 hsa-mir-200b Carcinoma, Hepatocellular Expression of the five most common HCC-involved miRNAs (miR-122, miR-200a, miR-200b, miR-221, miR-222) was examined in serum using quantitative real time PCR (qRT-PCR). +exosome 36285300 hsa-mir-21 Pancreatic Neoplasms Nerve Growth Factor (NGF) Encourages the Neuroinvasive Potential of Pancreatic Cancer Cells by Activating the Warburg Effect and Promoting Tumor Derived Exosomal miRNA-21 Expression. +genetics_knock down_suppress 36285295 hsa-mir-214 Fibrosis, Renal 3p knockdown can reduce renal interstitial fibrosis through the PTEN/PI3K/AKT pathway. +lncRNA target 36284668 hsa-mir-598 Retinoblastoma 3p inhibitor. +genetics_overexpression_promote 36284637 hsa-mir-3960 Pancreatic Carcinoma Overexpression of miR-3960 antagonized the promotion effect of exosomes on PC cells and the TFAP2A/PTEN/AKT signaling pathway, inhibiting the growth of tumors. +other 36284632 hsa-mir-375 Carcinoma, Hepatocellular miR-375 was obviously augmented in Exo(IL2-TAM) and HCC cells treated with Exo(IL2-TAM). +circulation_biomarker_diagnosis_down 36284455 hsa-mir-155 Herpesviridae Infections In this study, we discovered that the expression of GATA-binding protein 3 (GATA3) was lowly expressed in KS tissues and KSHV-infected cells, while microRNA-155 (miR-155) was highly expressed in KS serum and KSHV-infected cells. +circulation_biomarker_diagnosis_up 36284396 hsa-mir-210 Ischemic Stroke RESULTS: MiR-210 was significantly upregulated in exosomes of the MCAO plasma, and further enhanced by EA therapy. +transcription factor target 36284391 hsa-mir-9 Nervous System Diseases MiR-9 may be a potential target of nervous system diseases. +genetics_GWAS 36284378 hsa-mir-5189 Arthritis, Rheumatoid OBJECTIVE: To investigate the associations of miRNA-related genetic polymorphisms, including miRNA-5189 rs562929801, miRNA-595 rs4909237, SLCO1A2 rs4149009 and MTHFR rs3737966, and clinical response to methotrexate in Chinese rheumatoid arthritis patients. +genetics_GWAS 36284378 hsa-mir-595 Arthritis, Rheumatoid OBJECTIVE: To investigate the associations of miRNA-related genetic polymorphisms, including miRNA-5189 rs562929801, miRNA-595 rs4909237, SLCO1A2 rs4149009 and MTHFR rs3737966, and clinical response to methotrexate in Chinese rheumatoid arthritis patients. +other 36284205 hsa-mir-20 Obesity In patients with severe obesity and OSA, after 6 months with CPAP, we observed a significant decrease in miR21 (p<0.01), miR126 (p<0.001) and miR320 (p<0.001), with no changes in any miRNA in patients without OSA. +other 36284205 hsa-mir-126 Obesity In patients with severe obesity and OSA, after 6 months with CPAP, we observed a significant decrease in miR21 (p<0.01), miR126 (p<0.001) and miR320 (p<0.001), with no changes in any miRNA in patients without OSA. +other 36284205 hsa-mir-21 Obesity In patients with severe obesity and OSA, after 6 months with CPAP, we observed a significant decrease in miR21 (p<0.01), miR126 (p<0.001) and miR320 (p<0.001), with no changes in any miRNA in patients without OSA. +other 36284205 hsa-mir-21 Sleep Apnea, Obstructive In patients with severe obesity and OSA, after 6 months with CPAP, we observed a significant decrease in miR21 (p<0.01), miR126 (p<0.001) and miR320 (p<0.001), with no changes in any miRNA in patients without OSA. +other 36284205 hsa-mir-20 Sleep Apnea, Obstructive In patients with severe obesity and OSA, after 6 months with CPAP, we observed a significant decrease in miR21 (p<0.01), miR126 (p<0.001) and miR320 (p<0.001), with no changes in any miRNA in patients without OSA. +other 36284205 hsa-mir-126 Sleep Apnea, Obstructive In patients with severe obesity and OSA, after 6 months with CPAP, we observed a significant decrease in miR21 (p<0.01), miR126 (p<0.001) and miR320 (p<0.001), with no changes in any miRNA in patients without OSA. +lncRNA target 36283303 hsa-mir-159 Sepsis Our results suggested that LcmiR159-LcGAMYB and LcmiR828-LcTT2 modules participated in litchi downy blight possibly through regulating fruit senescence while LcmiR160-LcARF18 and LcmiR167-LcARF8 through SA-mediated defense response. +lncRNA target 36283303 hsa-mir-160 Sepsis Our results suggested that LcmiR159-LcGAMYB and LcmiR828-LcTT2 modules participated in litchi downy blight possibly through regulating fruit senescence while LcmiR160-LcARF18 and LcmiR167-LcARF8 through SA-mediated defense response. +other 36282999 hsa-mir-21 Diabetes Mellitus Differences in the expression patterns of miR-21 during diabetic wound healing identifies the potentially critical role of therapeutic timing, for miR-21 based therapies, in driving positive outcomes for patients. +other 36281935 hsa-mir-608 Endometriosis Based on our previous results, the aim of the present study was to explore the role of lncRNA long intergenic nonprotein coding RNA (LINC)01960201 in in vitro decidualization of endometrial stromal cells in endometriosis during the window of implantation, as well as to explore the biological function of LINC01960201, and the regulation of a disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAMTS7), hsamicroRNA (miR)760 and hsamiR608 in the decidualization of endometrial stromal cells with endometriosis. +exosome 36281649 hsa-mir-200b Breast Neoplasms Collectively, TXT-resistant TNBC cell-derived exosomal LINC00667 could decrease the chemosensitivity of TNBC cells to TXT via regulating miR-200b-3p/Bcl-2 axis. +genetics_overexpression_promote 36281584 hsa-mir-29a salivary gland adenoid cystic carcinoma CONCLUSIONS: Our results showed the downregulation of miR-29 and overexpression of miR-93 and miR-205 in the SACC group, and the correlation between miR-93 and VEGF suggests these biomarkers as potential prognostic markers in the future. +genetics_overexpression_promote 36281584 hsa-mir-205 salivary gland adenoid cystic carcinoma CONCLUSIONS: Our results showed the downregulation of miR-29 and overexpression of miR-93 and miR-205 in the SACC group, and the correlation between miR-93 and VEGF suggests these biomarkers as potential prognostic markers in the future. +genetics_overexpression_promote 36281584 hsa-mir-93 salivary gland adenoid cystic carcinoma CONCLUSIONS: Our results showed the downregulation of miR-29 and overexpression of miR-93 and miR-205 in the SACC group, and the correlation between miR-93 and VEGF suggests these biomarkers as potential prognostic markers in the future. +genetics_overexpression_promote 36281584 hsa-mir-29 salivary gland adenoid cystic carcinoma CONCLUSIONS: Our results showed the downregulation of miR-29 and overexpression of miR-93 and miR-205 in the SACC group, and the correlation between miR-93 and VEGF suggests these biomarkers as potential prognostic markers in the future. +lncRNA target 36281526 hsa-mir-101 Stomach Neoplasms The lncRNA SNHG22 promotes the proliferation, migration, and invasion of GC cells via the miR +transcription factor target 36281492 hsa-mir-9a Inflammatory Bowel Diseases This study finds that miRNA-9a-5p targets NOX4 to suppress ROS production, which plays an important role in mucosal barrier damage in IBD. +genetics_knock down_promote 36281372 hsa-mir-23b Carcinoma, Hepatocellular In addition, transforming growth factor beta1 (TGF-beta1) stimulation after miR-23b-3p overexpression induced neither the mesenchymal phenotype nor migratory property of HCC cells. +other 36280145 hsa-mir-143 Premature Birth Notably, miR-143, miR-30e-3p, and miR-199b were all significantly up-regulated, which is consistent with the 1 previous study of cervical microRNA and spontaneous preterm birth. +other 36280145 hsa-mir-199b Premature Birth Notably, miR-143, miR-30e-3p, and miR-199b were all significantly up-regulated, which is consistent with the 1 previous study of cervical microRNA and spontaneous preterm birth. +transcription factor target 36279730 hsa-mir-2115 Pre-Eclampsia 3p might interact with the GOT1 mRNA to downregulate its expression, further inhibiting the hypoxia-promoted ferroptosis in a PE model. +lncRNA target 36279670 hsa-mir-145 Arthritis, Rheumatoid 5p/FZD4 signal axis plays an important role in promoting the pathogenesis of RA, and CAR from CCO may inhibit RA pathology by combining the FZD4 and further blocking this signal axis. +circulation_biomarker_diagnosis_ns 36279183 hsa-mir-222 Prostatic Neoplasms The diagnostic value of the plasma miR222-3p for discrimination of the PC patients from healthy individuals was reasonable [cut-off value (fold change relative to miR16-5p) = 1.69, area under the curve = 0.73, sensitivity = 0.75 and specificity = 0.74]. +genetics_overexpression_suppress 36278816 hsa-mir-204 Gallbladder Neoplasms In addition, overexpression of FGFR2 restored the cell malignant behavior of GBC cells inhibited by miR +genetics_knock down_suppress 36278814 hsa-mir-761 Osteoarthritis An in vitro OA model was constructed by treating C28/I2 cells with LPS and treating them with overexpression or knockdown vector of circRNA-MSR, miR-761, and FBXO21, and autophagy inhibitor 3-MA. +other 36278683 hsa-mir-130b Precursor Cell Lymphoblastic Leukemia-Lymphoma Examination of the prognostic significance of miRNA expression in B-ALL indicate that the IK1-regulated miRNAs hsa-miR-26b, hsa-miR-130b and hsa-miR-4649 are significantly associated with outcome in B-ALL. +other 36278683 hsa-mir-26b Precursor Cell Lymphoblastic Leukemia-Lymphoma Examination of the prognostic significance of miRNA expression in B-ALL indicate that the IK1-regulated miRNAs hsa-miR-26b, hsa-miR-130b and hsa-miR-4649 are significantly associated with outcome in B-ALL. +other 36278683 hsa-mir-4649 Precursor Cell Lymphoblastic Leukemia-Lymphoma Examination of the prognostic significance of miRNA expression in B-ALL indicate that the IK1-regulated miRNAs hsa-miR-26b, hsa-miR-130b and hsa-miR-4649 are significantly associated with outcome in B-ALL. +genetics_knock down_promote 36278455 hsa-mir-1285 Carcinoma, Hepatocellular CONCLUSION: Our results suggested that the knockdown of lncRNA TCTN2 inhibited HCC development by regulating the miR +circulation_biomarker_diagnosis_ns 36278201 hsa-mir-23a Ischemic Stroke A panel of noncoding RNAs (miRNA-23a, miRNA-193a, miRNA-128, miRNA-99a, miRNA-let-7a, miRNA-494, miRNA-424, and lncRNA H19) were measured in the circulating neutrophils of AIS patients before rtPA treatment. miRNA-23a, miRNA-99a, and lncRNA H19 are worth further investigation for their effects in thrombolysis after AIS. +circulation_biomarker_diagnosis_ns 36278201 hsa-mir-99a Ischemic Stroke A panel of noncoding RNAs (miRNA-23a, miRNA-193a, miRNA-128, miRNA-99a, miRNA-let-7a, miRNA-494, miRNA-424, and lncRNA H19) were measured in the circulating neutrophils of AIS patients before rtPA treatment. miRNA-23a, miRNA-99a, and lncRNA H19 are worth further investigation for their effects in thrombolysis after AIS. +other 36277877 hsa-mir-708a Myopia Our findings may help deepen the understanding of the mechanisms behind the high expression of miR-708a and miR-148 in atrial tissues of patients with HM. +other 36277877 hsa-mir-148 Myopia Our findings may help deepen the understanding of the mechanisms behind the high expression of miR-708a and miR-148 in atrial tissues of patients with HM. +other 36277877 hsa-mir-148a Myopia Our findings may help deepen the understanding of the mechanisms behind the high expression of miR-708a and miR-148 in atrial tissues of patients with HM. +lncRNA target 36277475 hsa-mir-630 Uterine Cervical Neoplasms CONCLUSION: Taken together, our findings indicate a novel hypoxia-induced HIF-3alpha and miR-630 regulatory feedback loop contributing to metastasis and progression of cervical cancer cells and suggest that HIF-3alpha and miR-630 might act as potential biomarkers and therapeutic targets for cervical cancer in the future. +genetics_overexpression_suppress 36277474 hsa-mir-29b Pancreatic Carcinoma Treatment with the exosomal inhibitor (GW4869) prevented an increase in miR-29b expression and recused the reduced VEGF expression and tube formation and migration abilities of HUVECs cocultured with BxPC3 and AsPC-1 cells that overexpressed miR-29b. +genetics_knock down_promote 36277152 hsa-mir-590 Osteosarcoma In addition, MALAT1 knockdown upregulated the expression of miR +circulation_biomarker_diagnosis_ns 36277151 hsa-mir-203 Hemangioma Our previous study demonstrated that microRNA-203a-3p (miR-203a-3p) was involved in the regulation of long non-coding RNA MEG8-mediated the progression of hemangioma, which is a benign tumor characterized by endothelial hyperplasia in the blood vessels and primarily occurring in infants and females. +circulation_biomarker_diagnosis_ns 36277151 hsa-mir-203a Hemangioma Our previous study demonstrated that microRNA-203a-3p (miR-203a-3p) was involved in the regulation of long non-coding RNA MEG8-mediated the progression of hemangioma, which is a benign tumor characterized by endothelial hyperplasia in the blood vessels and primarily occurring in infants and females. +other 36276993 hsa-mir-146a Pancreatitis By using qPCR on our cerulein-induced pancreatitis cell model, it is worth noting that the change of miR-146a-5p expression in inflammation-related miRNAs in AP was predominant. There is potential for miR-146a-5p to serve as a diagnostic marker and therapeutic nucleic acid drug for AP. +genetics_overexpression_promote 36276867 hsa-mir-590 Colorectal Neoplasms HK2 overexpression or miR +transcription factor target 36276815 hsa-mir-44 Liver Cirrhosis In addition, TEVs inhibited TGF-beta1 signaling and miR-44 in TEVs had the potential inhibitory effect on liver fibrosis. +genetics_knock down_promote 36276300 hsa-mir-490 Osteosarcoma 3p inhibited cell progression of OS under hypoxia condition, while the effects were attenuated by KLF12 overexpression. +genetics_overexpression_suppress 36276294 hsa-mir-335 Carcinoma, Renal Cell The overexpression of CCRK partially reversed the inhibitory effects of miR +target gene 36276285 hsa-mir-193a Pancreatic Neoplasms miR-193a-5p Enhances the Radioresistance of Pancreatic Cancer Cells by Targeting ZFP57 and Activating the Wnt Pathway. +exosome 36276272 hsa-mir-613 Breast Neoplasms Exosome-Mediated Transfer of miR-3613-5p Enhances Doxorubicin Resistance by Suppression of PTEN Expression in Breast Cancer Cells. +other 36276146 hsa-mir-16 Biliary Tract Neoplasms 5p, and hsa-miR-26a-5p may act as key synergistic biomarkers and provide important molecular mechanisms that contribute to pathogenesis of BTC. +other 36276146 hsa-let-7c Biliary Tract Neoplasms 5p, and hsa-miR-26a-5p may act as key synergistic biomarkers and provide important molecular mechanisms that contribute to pathogenesis of BTC. +other 36276146 hsa-mir-26a Biliary Tract Neoplasms 5p, and hsa-miR-26a-5p may act as key synergistic biomarkers and provide important molecular mechanisms that contribute to pathogenesis of BTC. +other 36276146 hsa-mir-17 Biliary Tract Neoplasms 5p, and hsa-miR-26a-5p may act as key synergistic biomarkers and provide important molecular mechanisms that contribute to pathogenesis of BTC. +genetics_knock down_promote 36276139 hsa-mir-200b Colorectal Neoplasms Collectively, the loss of exosomal miR-200b-3p in hypoxia CAFs reduced the sensitivity to 5-FU in CRC by targeting HMGB3. +other 36276078 hsa-mir-223 Carcinoma, Non-Small-Cell Lung MiR-223-3p attenuates the migration and invasion of NSCLC cells by regulating NLRP3. +lncRNA target 36275896 hsa-mir-409 Cardiomyopathies 3p promotes cardiac fibrosis at least partially through Gpd1. +other 36275894 hsa-mir-451b Pulmonary Disease, Chronic Obstructive BACKGROUND: A previous study identified miR-451b as a potential biomarker in smoker with or without chronic obstructive pulmonary disease (COPD). However, the function and molecular mechanisms of miR-451b in the pathogenesis of COPD remain elusive. +exosome 36275890 hsa-mir-124 Psoriasis miR-124-3p Delivered Using Exosomes Attenuates the Keratinocyte Response to IL-17A Stimulation in Psoriasis. +target gene 36275636 hsa-mir-361 Colorectal Neoplasms ALDH1A3-Linc00284 Axis Mediates the Invasion of Colorectal Cancer by Targeting TGFbeta Signaling via Sponging miR-361-5p. +transcription factor target 36275459 hsa-mir-203a Colorectal Neoplasms The analysis of colorectal cancer 5'-isomiR-mediated regulatory networks revealed promising candidate tumor suppressor isomiRs: hsa-miR-203a-3p-+1, hsa-miR5p-+1 and hsa-miR-148a-3p-0. +transcription factor target 36275459 hsa-mir-192 Colorectal Neoplasms The analysis of colorectal cancer 5'-isomiR-mediated regulatory networks revealed promising candidate tumor suppressor isomiRs: hsa-miR-203a-3p-+1, hsa-miR5p-+1 and hsa-miR-148a-3p-0. +transcription factor target 36275459 hsa-mir-148a Colorectal Neoplasms The analysis of colorectal cancer 5'-isomiR-mediated regulatory networks revealed promising candidate tumor suppressor isomiRs: hsa-miR-203a-3p-+1, hsa-miR5p-+1 and hsa-miR-148a-3p-0. +other 36275122 hsa-mir-130b COVID-19 5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection. +other 36275122 hsa-mir-5100 COVID-19 5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection. +other 36275122 hsa-mir-598 COVID-19 5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection. +lncRNA target 36275122 hsa-mir-1307 COVID-19 3p play a critical role in SARS-CoV-2 infection, including via effects on disease progression and severity. +other 36275122 hsa-mir-505 COVID-19 5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection. +other 36275122 hsa-mir-34a COVID-19 5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection. +other 36275122 hsa-mir-129 COVID-19 5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection. +other 36275122 hsa-mir-181a-2 COVID-19 5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection. +other 36275122 hsa-mir-34c COVID-19 5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection. +other 36275122 hsa-mir-193a COVID-19 5p were also established in Vero cells related to general lung disease-related genes following SARS-CoV-2 infection. +lncRNA target 36274974 hsa-mir-7847 Sepsis Our experiments demonstrate that IL17-RA-1 attenuates the sepsis response through the miR3p/MAPK pathway, and this competing endogenous RNA (ceRNA) network may be a potential approach to predict and combat sepsis. +lncRNA target 36274500 hsa-mir-501 Stomach Neoplasms 3p facilitated cell proliferation, migration, and invasion, while inhibiting cell apoptosis in GC by targeting TM4SF1. +other 36274491 hsa-mir-3173 Lung Diseases "3p were identified as ""drivers"", and were all validated with expression alteration in lung disease patients from published studies." +other 36274491 hsa-mir-629 Lung Diseases "3p were identified as ""drivers"", and were all validated with expression alteration in lung disease patients from published studies." +other 36274491 hsa-mir-1343 Lung Diseases "3p were identified as ""drivers"", and were all validated with expression alteration in lung disease patients from published studies." +other 36274491 hsa-mir-9 Lung Diseases "3p were identified as ""drivers"", and were all validated with expression alteration in lung disease patients from published studies." +transcription factor target 36274382 hsa-mir-1 Bacterial Infections Moreover, interventions of miRNA-31 expressions via administration of miRNA-31 agomir reduces lung pathology and bacilli burdens via inducing up-regulation of gene sets involved in biological processes of defense response or cellular and chemical homeostasis in lungs. +other 36274378 hsa-mir-433 Colorectal Neoplasms 3p/E2F3 forms a positive loop which might become a potential biomarker in CRC. +circRNA target 36274319 hsa-mir-146a Inflammation Specifically, circRNA-05280 can regulate the level of apoptosis and inflammation of mammary gland by binding miR-146a and releasing the expression of miR-146a on target gene IRAK1. +other 36274229 hsa-mir-223 Granulomatous Disease, Chronic We engineered lentiviral vectors (LVs) carrying a universal promoter (EF1a) and two myeloid-specific promoters (miR223 and CD68) to drive the expression of green fluorescence protein (GFP) or CYBB, one of the key defective genes causing CGD. +genetics_knock down_suppress 36274134 hsa-mir-10 Osteosarcoma CONCLUSION: PCED1B-AS1 knockdown may inhibit OS cell proliferation and movement by regulating miR-10 gene methylation. +transcription factor target 36273900 hsa-mir-1281 Osteosarcoma Hence, our findings suggested that CTB-1 inhibited the cell growth, invasion, and migration of OS by upregulating miR-1281 and inhibiting PPIF expression, thereby providing a possible target drug for OS treatment. +genetics_knock down_promote 36273755 hsa-mir-581 Carcinoma, Hepatocellular Over-expression or knockdown of miR-581 could alter cell phenotypes caused by Lnc-COX7C-5 in HCC. +genetics_overexpression_promote 36273455 hsa-mir-133a Adenocarcinoma of Lung However, the promoting effects of GINS4 overexpression on LUAD could be offset by miR-133a-3p overexpression. +lncRNA target 36273140 hsa-mir-370 Ovarian Neoplasms CONCLUSION: circ_0025033 might promote ovarian cancer progression via hsa_miR +genetics_knock down_promote 36273122 hsa-mir-103a Carcinoma, Hepatocellular Overexpression of EVA1A significantly attenuated the cancer-promoting effects of miR-103a-3p in HCC cells, while knockdown of EVA1A alleviated the mitochondrial dysfunction and apoptosis caused by miR-103a-3p inhibition. +other 36273030 hsa-mir-548 Cakut Additionally, miR-548 family members have shown substantial enrichment in rare CNVs in CAKUT. +lncRNA target 36272469 hsa-mir-22 Colorectal Neoplasms 3p and plumbagin reduced colony formation and caused apoptotic cell death (detected by Annexin V/PI dual staining), possibly through increased ROS (detection by Dihydroethidium staining) and decreased MMP (detection by MitoTracker Orange staining) in CRC cells. +other 36272464 hsa-mir-142 Hematologic Diseases In summary, Lnc-TC/miR5p/CUL4B signaling axis promoted cell ferroptosis to participate in benzene hematotoxicity, and was a potential biomarker for risk screening and health surveillance of benzene-exposed workers. +other 36272464 hsa-mir-142 Siderosis In summary, Lnc-TC/miR5p/CUL4B signaling axis promoted cell ferroptosis to participate in benzene hematotoxicity, and was a potential biomarker for risk screening and health surveillance of benzene-exposed workers. +transcription factor target 36272206 hsa-mir-210 Cardiomyopathies 3p facilitated the proliferation of myocardial cells in H/R-treated H9C2 cells by suppressing TFR-mediated ferroptosis, which provided new methods to treat H/R-induced myocardial injury. +other 36272177 hsa-mir-184 Adenocarcinoma of Lung Finally, the circCENPF/hsa-miR-184 axis was identified as the most promising upstream regulatory pathway of HOXC9 in lung adenocarcinoma. +circulation_biomarker_diagnosis_up 36272155 hsa-mir-122 Intracranial Aneurysm 5p and KLF6 related plasmids was to figure out their roles in cell growth. +genetics_overexpression_promote 36272153 hsa-mir-15 Osteosarcoma However, overexpression of CDK6 could nullify the tumor-suppressive effects of miR-15 on the MG-63 osteosarcoma cells. +genetics_overexpression_promote 36272153 hsa-mir-15a Osteosarcoma However, overexpression of CDK6 could nullify the tumor-suppressive effects of miR-15 on the MG-63 osteosarcoma cells. +lncRNA target 36272152 hsa-mir-650 Ovarian Neoplasms The present study investigated the role of miR-650 in ovarian cancer by targeting Kruppel-like factor 12 (KLF12). Unlike miR-650, KLF12 showed a substantial up-regulation in ovarian cancer tissues and cell lines. +lncRNA target 36272150 hsa-mir-873 Osteosarcoma 5p/KLF5 axis confers vital effect on the occurrence and progression of OS, thus providing possible guidance for the clinical treatment of OS. +other 36271618 hsa-mir-206 Myocardial Ischemia 3p, miR-208a-3p are regulatable after 14 weeks of exercise training and proanthocyanidin extract consumption and could prevent myocardial injuries in ischemia. +other 36271618 hsa-mir-208a Myocardial Ischemia 3p, miR-208a-3p are regulatable after 14 weeks of exercise training and proanthocyanidin extract consumption and could prevent myocardial injuries in ischemia. +other 36271413 hsa-mir-185 Leukemia, Lymphocytic, Chronic, B-Cell Besides, the expression of circ_0002078 and TCF7L1 were significantly elevated and miR3p was obviously decreased in CLL patients. +genetics_GWAS 36270583 hsa-mir-21 Spinal Cord Injuries This study aims to develop a type of genetically engineered miR21-loaded exosomes that can be entrapped in collagen-I (Col-I) scaffold to repair SCI. +other 36270453 hsa-mir-196c Myocardial Reperfusion Injury The mir-196c-3p mimic (mimics) and photothermal nanoparticles (BTN) were co-encapsulated in an injectable Gel (mimics Gel/BTN) with NIR-II light-triggered release. +circulation_biomarker_diagnosis_down 36270080 hsa-mir-155 Carcinoma, Non-Small-Cell Lung Herein, employing miRNA-155 as a target, a novel integrated concentration and determination system of exosomes (ICDSE) was fabricated for the targeted enrichment of exosomes from the plasma of patients with non-small cell lung cancer and instant downstream analysis of exosomal miRNA. +other 36269619 hsa-mir-4756 COVID-19 3p, and hsa-mir-10a-5p, implicated in lung or other diseases induced by coronaviruses. +other 36269619 hsa-mir-10a COVID-19 3p, and hsa-mir-10a-5p, implicated in lung or other diseases induced by coronaviruses. +other 36269619 hsa-mir-221 COVID-19 3p, and hsa-mir-10a-5p, implicated in lung or other diseases induced by coronaviruses. +other 36269619 hsa-mir-192 COVID-19 3p, and hsa-mir-10a-5p, implicated in lung or other diseases induced by coronaviruses. +lncRNA target 36269529 hsa-mir-425 Osteosarcoma 5p/HMGB2 regulatory axis is a promising target in treating human OS. +lncRNA target 36269411 hsa-mir-4443 Rhabdomyosarcoma In this study, through experimental verification, we found miR-4443 to be downregulated in cells infected with EV71. +lncRNA target 36269304 hsa-mir-7977 Diabetes Mellitus Taken together, these findings suggest GO may be a superior auxiliary material for Ad-MSCs to facilitate diabetic wound healing via the Linc00324/miR-7977/STK4 pathway. +lncRNA target 36269211 hsa-mir-128 Neurotoxicity Syndromes 3p/PGC-1alpha axis may be a therapeutic target for PBDE-47 neurotoxicity. +genetics_overexpression_promote 36269185 hsa-mir-92a Retinal Neovascularization RESULTS: The overexpression of miR-92a-3p inhibited the development of retinal superficial vascular plexus and deep vascular plexus, decreased the expression of Ki67, and increased the expression of cleaved caspase-3 in isolectin B4-labeled retinal vascular ECs. +transcription factor target 36269185 hsa-mir-92a Retinal Diseases CONCLUSIONS: The miR-92a-3p could affect retinal angiogenesis by targeting SGK3 pathway, suggesting that miR-92a-3p may be a potential anti-angiogenic factor for retinal vascular disease. +transcription factor target 36269039 hsa-mir-29c Stomach Neoplasms To sum up, miR-29c-3p/MEST signaling pathway suppressed formation of malignant phenotypes of GC, and targeting the signaling pathway may be a new method for treating GC. +circRNA target 36268878 hsa-mir-145 Squamous Cell Carcinoma of Head and Neck CONCLUSION: circGOLPH3 exerted pro-oncogenic effects through the miR +other 36268280 hsa-mir-143 Adenocarcinoma of Lung We also identified the lncRNA UCA1/miR3p/CDK1 regulatory axis in LUAD. +genetics_overexpression_suppress 36268275 hsa-mir-22 Colorectal Neoplasms 3p inhibition or FSTL1 overexpression could offset the inhibition of TRPM2-AS downregulation on CRC cells. +other 36268199 hsa-mir-450b Diabetic Retinopathy CONCLUSION: SDMM capsules may prevent and treat diabetic retinopathy by regulating the expression of miR-450b-5p, miR-1249 and miR5p. +other 36268199 hsa-mir-155 Diabetic Retinopathy CONCLUSION: SDMM capsules may prevent and treat diabetic retinopathy by regulating the expression of miR-450b-5p, miR-1249 and miR5p. +other 36268199 hsa-mir-1249 Diabetic Retinopathy CONCLUSION: SDMM capsules may prevent and treat diabetic retinopathy by regulating the expression of miR-450b-5p, miR-1249 and miR5p. +other 36268034 hsa-mir-585 Stomach Neoplasms CONCLUSIONS: In conclusion, this study uncovered miR5p impedes gastric cancer proliferation and metastasis by orchestrating the interactions among CREB1, MAPK1 and MITF. +transcription factor target 36268033 hsa-mir-125b Liver Failure AIMS: To explore the role and mechanism of miR-125b-5p in the development of liver failure. CONCLUSION: Upregulation of miR-125b-5p can alleviate acute liver failure by regulating the Keap1/Nrf2/HO-1 pathway, and regulation of miR-125b-5p may serve as an alternative intervention for liver failure. +lncRNA target 36267915 hsa-mir-103 Acquired Immunodeficiency Syndrome We reveal that miRNA-103 mimics, as well as Nutlin-3, an inhibitor of Mdm2-mediated p53 degradation, decrease CCR5-dependent HIV-1 infection. +lncRNA target 36267843 hsa-mir-411 Hemangioma CONCLUSION: DSCAM-AS1 expedited HA progression via miR5p/TPD52 pathway, which provided a novel therapeutic option for HA treatment. +transcription factor target 36267816 hsa-mir-377 Heart Failure Collectively, our findings illuminate that miR-377 enhances myocardial hypertrophy caused by sepsis, by targeting Rcan2 and further regulating the Ca(2+)/CaN signaling pathway. +transcription factor target 36267816 hsa-mir-377 Sepsis Collectively, our findings illuminate that miR-377 enhances myocardial hypertrophy caused by sepsis, by targeting Rcan2 and further regulating the Ca(2+)/CaN signaling pathway. +other 36267811 hsa-mir-124 Myocardial Infarction 3p and PTEN, the areas of tissue structure damage, myocardial infarction, and fibrosis were substantially elevated. +lncRNA target 36267792 hsa-mir-671 Thyroid Cancer, Papillary In summary, circ_0001658 is a carcinogenesis-associated circRNA that regulates PI3K/AKT signaling via the miR +other 36267723 hsa-mir-423 Stomach Neoplasms The lncRNA TERC promotes gastric cancer cell proliferation, migration, and invasion by sponging miR-423-5p to regulate SOX12 expression. +transcription factor target 36267717 hsa-mir-16 Colorectal Neoplasms CONCLUSIONS: This is the first study to show that amentoflavone inhibits CRC EMT via the miR-16/HMGA2/beta-catenin pathway. +circulation_biomarker_prognosis_up 36267307 hsa-mir-18a Esophageal Squamous Cell Carcinoma Peripheral blood (PB) miR-18a-5p and ATM levels in these participants were quantified via qRT-PCR, and the correlations of the two genes with ESCC patients' clinicopathological characteristics were investigated. +genetics_overexpression_suppress 36267095 hsa-mir-19b Osteoarthritis In this study, miR-19b-3p was downregulated in osteoarthritic cartilage tissues and IL-1beta-stimulated primary chondrocytes, and miR-19b-3p overexpression reversed the inhibitory effect of IL-1beta on cell viability, the promotion effects of apoptosis, inflammatory factor secretion and extracellular matrix degradation, whereas the opposite effect was observed with miR-19b-3p inhibitor. +exosome 36266968 hsa-mir-155 Mite Infestations These results demonstrate that the niche factors in TAME, such as exosomal miRNA-155, regulate the function and polarity of macrophages to facilitate tumor progression. +circulation_biomarker_diagnosis_ns 36266728 hsa-mir-195 Carcinoma, Renal Cell 5p), PDCD5, HDAC3, and serum glucocorticoid-inducible kinase 1 (SGK1) was determined by RT-qPCR and Western blot analysis. +lncRNA target 36266695 hsa-mir-874 Osteosarcoma CONCLUSION: LncRNA CASC9 promotes cell proliferation and invasion in OS via miR3p/SOX12 axis. +other 36266590 hsa-mir-71 Echinococcosis Considering the function of microRNAs in many biological processes such as embryonic development, cell proliferation, and apoptosis, this study investigated the function and comparison of miR-71 and let-7 in fertile and non-fertile CE cysts. A comparison of Deltact of miR-71 and let-7 in fertile and non-fertile cysts did not show a significant difference (P = 0.911 and 0.354). +other 36266590 hsa-let-7 Echinococcosis Considering the function of microRNAs in many biological processes such as embryonic development, cell proliferation, and apoptosis, this study investigated the function and comparison of miR-71 and let-7 in fertile and non-fertile CE cysts. A comparison of Deltact of miR-71 and let-7 in fertile and non-fertile cysts did not show a significant difference (P = 0.911 and 0.354). +lncRNA target 36266384 hsa-mir-148a Squamous Cell Carcinoma of Head and Neck Finally, via upstream prognosis-related microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) prediction and co-expression analysis, we built an immune-related ceRNA network (LINC00052/hsa-miR-148a-3p/PLAU) related to HNSCC patient prognosis. +circulation_biomarker_diagnosis_up 36265417 hsa-mir-29 Pulmonary Fibrosis In human peripheral blood from IPF patients decreased miR-29 concentrations were associated with increased mortality in two cohorts potentially identified as a target population for treatment. +genetics_knock down_promote 36265392 hsa-mir-802 Squamous Cell Carcinoma of Head and Neck miR-802 overexpression reduced the malignant potential of OSCC cells largely by down-regulating MYO6. +transcription factor target 36264388 hsa-mir-21 Osteoarthritis We compare the efficacy of two treatments, MSC with their miR-21 inhibited through lentiviral transfection and their EV, against inflammation in a new OA animal model. +other 36264136 hsa-mir-616 Vasculitis, Central Nervous System ABRA showed higher levels of long noncoding RNAs and miR-616. +other 36264049 hsa-mir-106b Ovarian Neoplasms Up-regulation of oxidized low-density lipoprotein receptor 1 correlates with decreased miR-106b-5p, miR-93-5p, miR-3129-5p, miR-199b-3p, and miR-4465, higher recurrence rate, and poor prognosis in ovarian cancer. +lncRNA target 36263453 hsa-mir-212 Colorectal Neoplasms CONCLUSION: CRNDE led to the deterioration of impairment on cognition induced by ISO through suppressing miR5p expression and promoting neuroinflammation. +lncRNA target 36263172 hsa-mir-607 Esophageal Squamous Cell Carcinoma In the section of mechanism experiments, hsa_circ_0003823 regulated CRISP3 by targeting microRNA-607 (miR-607) to promote progression of ESCC. Conclusions: In this study, we elucidated the function of hsa_circ_0003823 and its role in promoting tumor progression, metastasis and Apatinib resistance of ESCC through miR-607/CRISP3 axis. +genetics_overexpression_promote 36263050 hsa-mir-210 Osteoarthritis 3p overexpression in ECs via adeno-associated virus (AAV) alleviated cartilage degradation, suppressed the type 17 immune response and relieved symptoms by attenuating subchondral Emcn(+) vasculature and subchondral bone remodeling. +genetics_knock down_suppress 36262998 hsa-mir-26a Esophageal Neoplasms MiR-26a-5p inhibitor can dramatically limit the ability of LINC00240 knockdown on plate colony formation and relocation of esophageal cancerous cells was demonstrated in colony formation and migration experiments. CONCLUSION: LINC00240 expression is elevated in esophageal cancerous tissues, and knocking down LINC00240 decreases esophageal cancer cell proliferation, clone formation, invasion, and migration via miR-26a-5p. +genetics_knock down_suppress 36262967 hsa-mir-1236 Carcinoma, Hepatocellular Finally, we found that knockdown of miR +other 36262826 hsa-mir-15a Endometriosis This study aims to uncover the role of long non-coding RNA BRAF-activated non-protein coding RNA (lncRNA BANCR)-mediated competing endogenous RNA mechanism in endometrial stromal cell (ESC) proliferation and invasion in EM by regulating miR-15a-5p/TRIM59. +circulation_biomarker_diagnosis_up 36262825 hsa-mir-184 Ischemic Stroke 5p) miRNAs in the serum exosomes between IS patients and healthy controls from GEO database (GSE199942) and 25 down-regulated genes of peripheral blood mononuclear cells of IS patients from GSE22255 were obtained with the help of the R software. +circulation_biomarker_diagnosis_up 36262825 hsa-mir-16 Ischemic Stroke 5p) miRNAs in the serum exosomes between IS patients and healthy controls from GEO database (GSE199942) and 25 down-regulated genes of peripheral blood mononuclear cells of IS patients from GSE22255 were obtained with the help of the R software. +circulation_biomarker_diagnosis_up 36262825 hsa-mir-15b Ischemic Stroke 5p) miRNAs in the serum exosomes between IS patients and healthy controls from GEO database (GSE199942) and 25 down-regulated genes of peripheral blood mononuclear cells of IS patients from GSE22255 were obtained with the help of the R software. +lncRNA target 36262353 hsa-mir-875 Osteosarcoma Targeting the LINC00909/miR +lncRNA target 36262350 hsa-mir-216 Colorectal Neoplasms The NEAT1/miR-216b/YY1 axis may be a novel therapeutic target for CRC. +lncRNA target 36262350 hsa-mir-216b Colorectal Neoplasms The NEAT1/miR-216b/YY1 axis may be a novel therapeutic target for CRC. +lncRNA target 36262285 hsa-mir-625 Urinary Bladder Neoplasms OBJECTIVE: This study further explored LINC00958's role in promoting tumor angiogenesis (AG) and oxidative stress (OS) development by inhibiting BC cell autophagy through sponge adsorption of miR +genetics_overexpression_promote 36262247 hsa-mir-1182 Colorectal Neoplasms FAM230B overexpression increased the expression levels of premature miR-1182 but decreased the expression levels of mature miR-1182 in CRC cells. +transcription factor target 36262165 hsa-mir-153 Cardiomegaly In short, Gm43843 promotes cardiac hypertrophy via miR +lncRNA target 36261179 hsa-mir-194 Gallbladder Neoplasms CONCLUSIONS: SNHG1 silencing suppressed the viability, proliferation and invasion of GBC cells via targeting miR +lncRNA target 36261177 hsa-mir-141 Pneumonia, Mycoplasma CONCLUSIONS: MALAT1-201 derived from MSC-Ex regulated the proliferation, apoptosis and migration of HTR8-Svneo cells by targeting miR-141, which indicated a promising therapeutic target for PE. +other 36261176 hsa-mir-145 Colonic Neoplasms 3p negatively modulated the expression of CDK1, thus attenuating the oncogenic effects produced by CDK1 in CC. +lncRNA target 36261079 hsa-mir-144 Schizophrenia In conclusion, this study revealed that icariin may have therapeutic effects on schizophrenia-like disorders via regulating the miR3p/ATP1B2/mTOR signalling, suggesting that icariin has potential to become an antipsychotic drug. +other 36261031 hsa-mir-3917 Lung Neoplasms miR-3917 is highly expressed in lung cancer tissues and M2-Ex. M2-Ex can transfer miR-3917 into lung cancer cells and promote lung cancer progression, providing theoretical basis for the diagnosis and effective treatment of lung cancer. +genetics_overexpression_promote 36260870 hsa-mir-126 Adenocarcinoma of Lung The overexpression of miR +genetics_overexpression_promote 36260870 hsa-mir-1 Adenocarcinoma of Lung The overexpression of miR +lncRNA target 36260520 hsa-mir-299 Carcinoma, Hepatocellular Matrine stimulates HCC cell apoptosis and represses the process of EMT and stemness through the miR +genetics_overexpression_promote 36260266 hsa-mir-633 Stomach Neoplasms Overexpression of miR-633 inhibits the proliferation and migration of GC cells and induces apoptosis and cell cycle arrest at the in G(1) phase. +circulation_biomarker_diagnosis_up 36259475 hsa-mir-21 Hypertension We aimed to evaluate the effects of MitoQ supplementation and moderate endurance training (ET), alone and in combination, on cardiac function, blood pressure, the circulatory levels of miRNA-21 and miRNA-222, and oxidative status in individuals with HTN. CONCLUSION: MitoQ and ET, individually and more pronouncedly in combination, can improve cardiovascular health in people with high blood pressure (BP) by reducing inflammation and increasing antioxidant defense, in association with reduction in circulatory miR-21 and miR-222 levels (registration number: IRCT20190228042870N1). +circulation_biomarker_diagnosis_up 36259475 hsa-mir-222 Hypertension We aimed to evaluate the effects of MitoQ supplementation and moderate endurance training (ET), alone and in combination, on cardiac function, blood pressure, the circulatory levels of miRNA-21 and miRNA-222, and oxidative status in individuals with HTN. CONCLUSION: MitoQ and ET, individually and more pronouncedly in combination, can improve cardiovascular health in people with high blood pressure (BP) by reducing inflammation and increasing antioxidant defense, in association with reduction in circulatory miR-21 and miR-222 levels (registration number: IRCT20190228042870N1). +genetics_GWAS 36258913 hsa-mir-499 Carcinoma, Non-Small-Cell Lung SNPs Rs11614913 in miR196a and Rs3746444 in miR-499 are implicated in the development of cancers such as non-small cell lung cancer (NSCLC) in non-Arabic subjects. +genetics_GWAS 36258913 hsa-mir-196a Carcinoma, Non-Small-Cell Lung SNPs Rs11614913 in miR196a and Rs3746444 in miR-499 are implicated in the development of cancers such as non-small cell lung cancer (NSCLC) in non-Arabic subjects. +circulation_biomarker_diagnosis_ns 36258850 hsa-mir-149 Sleep Apnea, Obstructive This study aimed to examine the serum expression of microRNA +circulation_biomarker_diagnosis_ns 36258850 hsa-mir-149 Obesity This study aimed to examine the serum expression of microRNA +circulation_biomarker_diagnosis_ns 36258728 hsa-mir-326 Platelet Storage Lesion Differential miRNA-326 and its target gene, Bcl-xL and Bak, expression levels at different points of platelets storage are promising tools as biomarkers for platelets undergoing PSL in blood banks. +other 36257575 hsa-mir-124 Irritable Bowel Syndrome MiR3p antagomir restored pain responses downregulated by shcircKcnk9 in IBS-like rats. +other 36257575 hsa-mir-124 Visceral Hypersensitivity MiR3p antagomir restored pain responses downregulated by shcircKcnk9 in IBS-like rats. +other 36257575 hsa-mir-124 Cancer-Associated Cachexia MiR3p antagomir restored pain responses downregulated by shcircKcnk9 in IBS-like rats. +lncRNA target 36257574 hsa-mir-152 Depression PERSPECTIVE: LncRNA XR_351665 in CeA functions as a ceRNA to block the inhibitory effect of miR +lncRNA target 36257574 hsa-mir-152 Chronic Pain PERSPECTIVE: LncRNA XR_351665 in CeA functions as a ceRNA to block the inhibitory effect of miR +genetics_overexpression_promote 36257404 hsa-mir-26a Diabetic Nephropathies We determined that miR-26a-5p overexpression ameliorated podocyte injury in DN via binding to 3'-UTR of Trpc6, as evidenced by the markedly reduced activity of luciferase reporters by miR-26a-5p mimic. +lncRNA target 36255597 hsa-mir-140 Esophageal Neoplasms In addition, DGE identified target genes of miR +lncRNA target 36255069 hsa-mir-513a Carcinoma, Hepatocellular These findings unraveled that circ_0003998 elevated 5-FU resistance in HCC by sponging miR-513a-5p to upregulate the level of ARK5, indicating that circ_0003998 might be used as a target to improve 5-FU therapy for HCC. +genetics_knock down_suppress 36255068 hsa-mir-543 Ovarian Neoplasms Circ_0026123 functionally targeted miR-543, and knockdown of miR-543 reversed the impacts of circ_0026123 deficiency on DDP sensitivity and the malignant behaviors of DDP-resistant OC cells. RAB1A was a target of miR-543, RAB1A overexpression attenuated the inhibitory functions of miR-543 on DDP resistance and the malignant phenotypes of DDP-resistant OC cells. +lncRNA target 36255066 hsa-mir-128 Squamous Cell Carcinoma of Head and Neck Further research is underway to understand how miR3p regulates oncogenesis in TSCC via MAP2K7 and associated pathways. +other 36254861 hsa-mir-199a Myocardial Reperfusion Injury Recent studies have revealed that miR-199a-5p participates in the process of myocardial I/R injury, but the precise roles and molecular mechanisms of miR-199a-5p in myocardial I/R injury remain not well-studied. Herein, the present study aimed to explore the function and mechanisms by which miR-199a-5p regulates whether miR-199a-5p contributes to ferroptosis-induced cardiomyocyte death responding to oxygen-glucose deprivation/reoxygenation (OGD/R) injury, an in vitro model of myocardial I/R injury focusing on Akt/eNOS signaling pathway. +transcription factor target 36254861 hsa-mir-199a Hypoxia-Ischemia, Brain In summary, our findings demonstrated that miR-199a-5p plays a central role in stimulating ferroptosis-induced cardiomyocyte death during ischemic/hypoxic injury via inhibiting Akt/eNOS signaling pathway. +lncRNA target 36254861 hsa-mir-199a Siderosis In summary, our findings demonstrated that miR-199a-5p plays a central role in stimulating ferroptosis-induced cardiomyocyte death during ischemic/hypoxic injury via inhibiting Akt/eNOS signaling pathway. +transcription factor target 36254623 hsa-mir-371a Neoplasms, Germ Cell and Embryonal Of the 10 chemotherapy naive patients, nine had viable seminoma at RPLND, and seven had elevated miR-371a-3p expression. +transcription factor target 36254623 hsa-mir-371a Seminoma Of the 10 chemotherapy naive patients, nine had viable seminoma at RPLND, and seven had elevated miR-371a-3p expression. +other 36254341 hsa-mir-184a Angioedemas, Hereditary AKT2, the mRNA regulated by the differentially-expressed miR-184A, was also associated with HAE attacks. +circulation_biomarker_diagnosis_ns 36254252 hsa-mir-4530 Pancreatic Carcinoma Therefore, we detected a promising three-miRNA panel in the plasma for noninvasive PC diagnosis (miR-125a-3p, miR-4530, and miR-92a +circulation_biomarker_diagnosis_ns 36254252 hsa-mir-125a Pancreatic Carcinoma Therefore, we detected a promising three-miRNA panel in the plasma for noninvasive PC diagnosis (miR-125a-3p, miR-4530, and miR-92a +circulation_biomarker_diagnosis_ns 36254252 hsa-mir-92a-2 Pancreatic Carcinoma Therefore, we detected a promising three-miRNA panel in the plasma for noninvasive PC diagnosis (miR-125a-3p, miR-4530, and miR-92a +other 36254230 hsa-mir-192 Carcinoma, Hepatocellular RESULT: CARMN was considered to be the potential upstream lncRNA for the hsa-miR5p/LOXL2 axis in HCC. +transcription factor target 36254157 hsa-mir-181d Optic Nerve Injuries CONCLUSION: miR-181d-5p can protect against the deterioration of TON by inhibiting RGCs death, astrocyte development, oxidative stress, and inflammation by targeting NFIA. +lncRNA target 36254053 hsa-mir-92a Carcinoma, Non-Small-Cell Lung To assess the potential prognostic value of miR-92a as a new biomarker in non-small cell lung cancer (NSCLC) via clinical evaluation, a total of 100 patients with NSCLC admitted to the Respiratory and Intensive Care Department of Suining Central Hospital in Sichuan Province between August 2007 and April 2020 were retrospectively analyzed. +exosome 36253857 hsa-mir-493 Asthma, Allergic 5p, thus DC-derived exosomal miR +genetics_knock down_promote 36253542 hsa-mir-1270 Adenocarcinoma of Lung We show that the loss of miRNAs (miR) +genetics_overexpression_promote 36252912 hsa-mir-451a Thyroid Cancer, Papillary Overexpression of DCBLD2 and AKT1 could restore the effect of miR-451a on PTC cells. +other 36252562 hsa-mir-138 Muscular Atrophy, Spinal Silencing of miRNA-138 increased neuronal apoptosis and spinal cord atrophy significantly. +genetics_knock down_suppress 36252562 hsa-mir-138 Myelodysplastic Syndromes Comparatively, knockdown of miRNA-138 downregulated Shh levels in myelodysplastic regions. +circulation_biomarker_diagnosis_ns 36252485 hsa-mir-214 Hashimoto Disease LINC00842 functioned as a miR-214 sponge in HT patients and thyroid epithelial follicular cells. These findings concluded that AMIO-drove XBP1s aggravated endoplasmic reticulum stress and apoptosis in HT via modulating LINC00842/miR-214/FASL axis, providing a new sight for the therapeutic strategy of AMIO-induced HT. +genetics_knock down_suppress 36252478 hsa-mir-450b Acute Lung Injury CONCLUSION: CircPalm2 knockdown can alleviate LPS-evoked MPVEC apoptosis and inflammation via miR-450b-5p/ROCK1 axis, suggesting the potential involvement of this ceRNA network in sepsis-ALI and a broader approach for the therapy of sepsis-ALI. +genetics_knock down_suppress 36252478 hsa-mir-450b Systemic Inflammatory Response Syndrome CONCLUSION: CircPalm2 knockdown can alleviate LPS-evoked MPVEC apoptosis and inflammation via miR-450b-5p/ROCK1 axis, suggesting the potential involvement of this ceRNA network in sepsis-ALI and a broader approach for the therapy of sepsis-ALI. +genetics_knock down_suppress 36252478 hsa-mir-450b Sepsis CONCLUSION: CircPalm2 knockdown can alleviate LPS-evoked MPVEC apoptosis and inflammation via miR-450b-5p/ROCK1 axis, suggesting the potential involvement of this ceRNA network in sepsis-ALI and a broader approach for the therapy of sepsis-ALI. +genetics_knock down_promote 36252429 hsa-mir-335 Ischemic Stroke CONCLUSION: Circ_0101874 knockdown alleviated OGD-induced neuronal cell injury by suppressing PDE4D via regulating miR +transcription factor target 36252394 hsa-mir-26a Endometritis miR-26a and MAP3K8 may be a promising biomarker and therapeutic target for dairy cow endometritis. +lncRNA target 36252156 hsa-mir-377 Esophageal Squamous Cell Carcinoma The results suggest that the molecular targeting of the lncRNA NEAT1 and miR-377/E2F3 axis could prove beneficial in the management of esophageal cancer. +genetics_knock down_suppress 36252137 hsa-mir-1249 Hypertension, Pulmonary In rats, the repression of microR-1249 in eEVs by microR-1249 inhibitor, histone deacetylase 10 overexpression, or calcium-sensing receptor knockout profoundly inhibited the proliferative capacities and diminished apoptosis-resistance of pulmonary artery smooth muscle cells and pulmonary hypertension development in rats intravenously administrated with eEVs preparation from cigarette smoke extract-treated pulmonary artery endothelial cells. CONCLUSIONS: Cigarette smoke-enriched microR-1249 in endothelial extracellular vesicles facilitates the hyperproliferative and antiapoptotic status of pulmonary artery smooth muscle cells promoting pulmonary hypertension evolution through the inhibition of histone deacetylase 10-NFkappaB-calcium-sensing receptor cascade. +circulation_biomarker_prognosis_up 36251659 hsa-mir-1246 Dengue CONCLUSION: Our study indicated that circulating miRNAs, especially miR +genetics_overexpression_promote 36251494 hsa-mir-450b Squamous Cell Carcinoma of Head and Neck miR-450b was found to be overexpressed in OSCC animal samples, HNSCC samples and human OSCC cells. +circulation_biomarker_diagnosis_up 36251230 hsa-mir-502 Alzheimer Disease Dataset analysis showed that the expression of hsa-miR200a-3p and hsa-miR502-3p were up-regulated in AD. CONCLUSION: Totally, hsa-miR200a-3p and hsa-miR502-3p are upregulated in AD and their plasma levels can discriminate AD and healthy people, highlighting their potential as blood-based biomarker for AD. +circulation_biomarker_diagnosis_up 36251230 hsa-mir-200a Alzheimer Disease Dataset analysis showed that the expression of hsa-miR200a-3p and hsa-miR502-3p were up-regulated in AD. CONCLUSION: Totally, hsa-miR200a-3p and hsa-miR502-3p are upregulated in AD and their plasma levels can discriminate AD and healthy people, highlighting their potential as blood-based biomarker for AD. +transcription factor target 36251141 hsa-mir-19b Arthritis, Rheumatoid GA upregulated miR-19b-3p expression, downregulated RAF1 expression, inhibited ERK1/2 phosphorylation, induced MH7A cell apoptosis and suppressed MH7A cell invasion and migration (P<0.05 or P<0.01). +other 36250950 hsa-mir-149 Stomach Neoplasms Rescue assays indicated that circBGN regulates GC cell proliferation and invasion by upregulating miR5p/IL6 axis output. +circulation_biomarker_diagnosis_up 36250874 hsa-mir-21 Hypoxia To test this hypothesis, we exposed male rats to 6 h of 12% O(2) and measured circulating levels of ET-1 and miR-21, pre, during, and posthypoxia. +genetics_knock down_suppress 36250827 hsa-let-7c Abortion, Habitual 3p, and miR-let-7c expression levels in plasma samples of patients with idiopathic recurrent pregnancy loss (iRPL) and healthy subjects and to evaluate their potential diagnostic value in diagnosis of iRPL. +genetics_overexpression_promote 36250561 hsa-mir-499 Angelman Syndrome 5p overexpression could promote the proliferation and migration of MOVAS. +other 36250561 hsa-mir-499 Cardiovascular Diseases The miR5p/SOX6 axis may present a promising therapeutic implication for the prevention and treatment of cardiovascular diseases. +genetics_overexpression_promote 36250558 hsa-mir-186 Myocardial Infarction, Acute Rescue experiments revealed that miR-186 overexpression or YY1 suppression partially reversed the roles of ox-EVs overexpressing CLDN10-AS1 in ox-LDL-induced VEC injury. +other 36250452 hsa-mir-574 Osteosarcoma 3p/IL-6 axis regulation, suggesting its potency as a promising biomarker for treating OS. +lncRNA target 36250437 hsa-mir-128 Epilepsy 3p attenuates penicillin-induced cell injury and inflammation in astrocytes by targeting MAPK6, thus providing a protective role in epilepsy. +lncRNA target 36250223 hsa-mir-338 Opitz GBBB Syndrome, X-Linked 3p/MEF2C is a prospective target for OS treatment. +other 36250210 hsa-mir-21 Pre-Eclampsia The upregulation of placental miR21 abundance by placenta-specific nanoparticles loaded with agomir-miR21 during placentation interfered with PPP2R2B and activated the Hippo pathway in the placenta, leading to a PE-like phenotype. Thus, aberrant elevation of miR21 impairs EVT mobility by modulating the PP2A Bbeta/Hippo axis, which is one of the causes of PE. +other 36250208 hsa-mir-149 Colitis 3p in colon inflammation, which may serve as an attractive therapeutic tool for colitis or IBD, and even colitis-associated carcinoma. +circulation_biomarker_diagnosis_down 36250025 hsa-mir-335 Ischemic Stroke Conclusion: Our results revealed that serum TUG1, miR-21, NBAT1, and miR-335 could be promising molecular diagnostic markers for AIS as these biomarkers could discriminate between AIS patients and healthy controls. +other 36249798 hsa-mir-143 Duodenal Ulcer We found that cold stimulation induced gastric mucosa injury with a reduction in glutamate levels and xCT activity and upregulation of miR-143, miR-152, and miR-181 expression. The present study suggests that miR-143, miR-152, and miR-181 are involved in cold stimulation-induced acute gastric mucosal injury. +other 36249798 hsa-mir-181 Duodenal Ulcer We found that cold stimulation induced gastric mucosa injury with a reduction in glutamate levels and xCT activity and upregulation of miR-143, miR-152, and miR-181 expression. The present study suggests that miR-143, miR-152, and miR-181 are involved in cold stimulation-induced acute gastric mucosal injury. +other 36249798 hsa-mir-152 Duodenal Ulcer We found that cold stimulation induced gastric mucosa injury with a reduction in glutamate levels and xCT activity and upregulation of miR-143, miR-152, and miR-181 expression. The present study suggests that miR-143, miR-152, and miR-181 are involved in cold stimulation-induced acute gastric mucosal injury. +lncRNA target 36249712 hsa-mir-432 Carcinoma, Non-Small-Cell Lung circPTN regulates the malignant progression of NSCLC cells through targeting the miR +other 36249345 hsa-mir-185 Cataract, Congenital Zonular, with Sutural Opacities Expressions of miR-22 and miR-185 were not significantly increased when exposed to CSE from CCs or HTPs. +other 36249345 hsa-mir-22 Cataract, Congenital Zonular, with Sutural Opacities Expressions of miR-22 and miR-185 were not significantly increased when exposed to CSE from CCs or HTPs. +genetics_knock down_promote 36248798 hsa-mir-216a Squamous Cell Carcinoma of Head and Neck An miR-216a-5p inhibitor reversed the effect of HCP5 knockdown on the proliferation and migration and invasive ability of LSCC cells. +lncRNA target 36248732 hsa-mir-181a Autoimmune Diseases Collectively, our results reveal a previously unappreciated T cell-intrinsic role of miR-181a-5p in restraining autoimmunity and may provide a potential therapeutic target for uveitis treatment. +genetics_overexpression_promote 36248732 hsa-mir-181a Uveitis Th17 cells overexpressing miR-181a-5p exhibited impaired ability to induce pathogenesis in an adoptive transfer model of experimental autoimmune uveitis (EAU). +target gene 36248434 hsa-mir-378 Leukemia, Myeloid LncRNA-PAX8-AS1 Silencing Decreases Cell Viability, Enhances Apoptosis, and Suppresses Doxorubicin Resistance in Myeloid Leukemia via the miR-378g/ERBB2 Axis. +lncRNA target 36248429 hsa-mir-511 Alzheimer Disease CONCLUSION: Moxibustion at acupoints of the governor vessel can suppress the lncRNA Six3os1 expression, promote cell autophagy, accelerate Abeta1-42 clearance and alleviate cognitive dysfunction of AD mediated by the PI3K/AKT/mTOR signaling pathway through the lncRNA Six3os1/miR +other 36248425 hsa-mir-6511b Lymphoma LncHOTAIR/hsa-miR-6511b-5p/ATG7 could regulate the proliferation, apoptosis, and autophagy of Raji and BJAB lymphoma cells. +lncRNA target 36248422 hsa-mir-200 Colorectal Neoplasms In previous mechanistic studies, we found that the miR-200s expression in CRC is associated with L-OHP sensitivity through regulation of MDR1/p-gp and the downstream c-JunN-terminal kinase (JNK) signaling pathway. +target gene 36248404 hsa-mir-338 Ovarian Neoplasms Circ_0109046 silencing impaired the proliferation, migration, and invasion of ovarian cancer cells through negatively regulating miR-338-3p in vitro +other 36248377 hsa-mir-1248 Pituitary Adenoma, Non-Functioning Hsa-miR-1248 showed exceptional connectivity in the ceRNA regulatory network, which could be closely related to the invasiveness of NFPAs. +epigenetics 36248294 hsa-mir-205 Parkinson Disease MiR-205 Regulates LRRK2 Expression in Dopamine Neurons in Parkinson's Disease through Methylation Modification. +exosome 36248244 hsa-mir-106a Glioma However, hypoxic glioma cell-derived exosomes markedly promoted the proliferation and suppressed the apoptosis in TMZ-treated glioma cells, and miR-106a-5p inhibitor was able to abolish these phenomena. +lncRNA target 36248191 hsa-mir-652 Atherosclerosis 3p regulates the lipid metabolism of macrophages to alleviate atherosclerosis by inhibiting TP53 expression. +transcription factor target 36247625 hsa-mir-408a Dehydration Finally, miR408a was selected for functional analysis and demonstrated to be a negative regulator of drought response, mainly through regulation of reactive oxygen species accumulation in the maize root system. +circulation_biomarker_diagnosis_ns 36247409 hsa-mir-1 Breast Neoplasms In this study, the expression of miR-29b and miR-31 was assessed in blood samples from 200 patients with breast cancer and wholesome volunteer women using quantitative reverse transcriptase PCR to evaluate their role in the disease. MiR-29b and miR-31 could be useful markers for predicting breast cancer relapse and mortality. +circulation_biomarker_diagnosis_ns 36247409 hsa-mir-29b Breast Neoplasms In this study, the expression of miR-29b and miR-31 was assessed in blood samples from 200 patients with breast cancer and wholesome volunteer women using quantitative reverse transcriptase PCR to evaluate their role in the disease. MiR-29b and miR-31 could be useful markers for predicting breast cancer relapse and mortality. +circulation_biomarker_diagnosis_up 36247296 hsa-mir-223 Diabetes Mellitus, Type 2 The expression of miR-223 and miR-200b in serum and gingival crevicular fluid was elevated higher in the comorbid group than in the other three groups (P<0.05), and their expressions in gingival crevicular fluid contributed to the differential diagnosis of periodontal disease from diabetes mellitus comorbid with periodontal disease (P<0.05). CONCLUSIONS: Our findings indicate a close link between the levels of miR-223 and miR-200b in serum and gingival crevicular fluid and susceptibility to T2DM as well as the pathogenesis of periodontal disease. +circulation_biomarker_diagnosis_up 36247296 hsa-mir-223 Periodontal Diseases The expression of miR-223 and miR-200b in serum and gingival crevicular fluid was elevated higher in the comorbid group than in the other three groups (P<0.05), and their expressions in gingival crevicular fluid contributed to the differential diagnosis of periodontal disease from diabetes mellitus comorbid with periodontal disease (P<0.05). CONCLUSIONS: Our findings indicate a close link between the levels of miR-223 and miR-200b in serum and gingival crevicular fluid and susceptibility to T2DM as well as the pathogenesis of periodontal disease. +circulation_biomarker_diagnosis_up 36247296 hsa-mir-200b Periodontal Diseases The expression of miR-223 and miR-200b in serum and gingival crevicular fluid was elevated higher in the comorbid group than in the other three groups (P<0.05), and their expressions in gingival crevicular fluid contributed to the differential diagnosis of periodontal disease from diabetes mellitus comorbid with periodontal disease (P<0.05). CONCLUSIONS: Our findings indicate a close link between the levels of miR-223 and miR-200b in serum and gingival crevicular fluid and susceptibility to T2DM as well as the pathogenesis of periodontal disease. +circulation_biomarker_diagnosis_up 36247296 hsa-mir-200b Diabetes Mellitus, Type 2 The expression of miR-223 and miR-200b in serum and gingival crevicular fluid was elevated higher in the comorbid group than in the other three groups (P<0.05), and their expressions in gingival crevicular fluid contributed to the differential diagnosis of periodontal disease from diabetes mellitus comorbid with periodontal disease (P<0.05). CONCLUSIONS: Our findings indicate a close link between the levels of miR-223 and miR-200b in serum and gingival crevicular fluid and susceptibility to T2DM as well as the pathogenesis of periodontal disease. +other 36247288 hsa-mir-7706 Intrahepatic Cholestasis of Pregnancy 3p) may be a useful noninvasive diagnostic biomarker of IHCP. +other 36247288 hsa-mir-877 Intrahepatic Cholestasis of Pregnancy 3p) may be a useful noninvasive diagnostic biomarker of IHCP. +other 36247288 hsa-mir-128 Intrahepatic Cholestasis of Pregnancy 3p) may be a useful noninvasive diagnostic biomarker of IHCP. +lncRNA target 36247255 hsa-mir-223 Cardiomyopathies Further experiments demonstrated that FGD5-AS1 modulated Akt activity to reduce myocardial injury through miR3p. +lncRNA target 36247255 hsa-mir-223 Myocardial Infarction 3p/Akt pathway is involved in AMI, suggesting that FGD5-AS1 may act as a potential biomarker and therapeutic target for AMI. +target gene 36247254 hsa-mir-145 Osteosarcoma LncRNA UCA1 accelerates osteosarcoma progression via miR-145 and Wnt/β-catenin pathway. +genetics_knock down_suppress 36247250 hsa-mir-486a Endometrial Hyperplasia Gain- and loss-of-function experiments revealed that transfection of miR-486a-3p mimic inhibited proliferation and inflammation of VSMCs, which improved intimal hyperplasia. +genetics_knock down_promote 36247250 hsa-mir-486a Inflammation Gain- and loss-of-function experiments revealed that transfection of miR-486a-3p mimic inhibited proliferation and inflammation of VSMCs, which improved intimal hyperplasia. +circulation_biomarker_diagnosis_up 36247238 hsa-mir-197 Hypertension, Pregnancy-Induced RESULTS: In pregnant women with PIH, serum UCA1 and HDAC2 expression was downregulated and serum miR +other 36246958 hsa-mir-335 Pulmonary Arterial Hypertension Our work highlights the role of miR5p and calumenin in RV remodeling and may lead to the development of novel therapeutic strategies for right heart failure. +other 36246623 hsa-mir-29c Carcinoma, Hepatocellular The DUXAP8-miR-29c-FANCD2 and LINC00511-miR-29c-FANCD2 axes were identified as the most likely ncRNA-associated upstream regulatory axis of FANCD2 in HCC. +lncRNA target 36246567 hsa-mir-4500 Stomach Neoplasms HEIH promotes gastric cancer development by inhibiting miR-4500. +lncRNA target 36246563 hsa-mir-96 Colorectal Neoplasms Analysis of LINC01314 and miR-96 Expression in Colorectal Cancer Patients via METHODS: A tissue microarray (TMA) containing 76 individual colorectal tumor samples and 28 adjacent normal samples was constructed, and the expression levels of LINC01314 and miR-96 were detected by fluorescence in situ hybridization. +lncRNA target 36246560 hsa-mir-21 Respiratory Distress Syndrome Thus, the camk2g/miR3p/lncRNA/circRNA network, CXCL10/CXCR3, and IL-17 signaling pathways might provide novel insights and targets for further studying the lung injury mechanism and clinical treatment. +circulation_biomarker_prognosis_up 36245984 hsa-mir-651 Carcinoma, Hepatocellular RESULTS: Serum miR-3651 was found to be higher in HCC patients than in LC patients and normal persons, and it presented a sensitivity and specificity of 57.14% and 94.00%, respectively, in forecasting the occurrence of HCC in LC patients. +target gene 36245704 hsa-mir-361 Prostatic Neoplasms lncRNA MIAT participated in prostate cancer by regulating cell proliferation and apoptosis via miR-361-3p/CCAR2 axis. +genetics_overexpression_promote 36245426 hsa-mir-377 Endometrial Neoplasms 3p, and overexpression of miR +genetics_overexpression_promote 36245214 hsa-mir-378a Stomach Neoplasms RESULTS: We report the first evidence that miR-378a-3p is downregulated in GC, whereas its overexpression inhibits proliferation, invasion, and migration as well as promotes apoptosis in GC cells. +genetics_overexpression_promote 36245088 hsa-mir-187 Prostatic Neoplasms Prostate cancer cells were then exposed to BMSC-exos that were treated with either miR-187 mimic/inhibitor or CD276 overexpression for pinpointing the in vitro and in vivo effects of exosomal miR-187. +lncRNA target 36244909 hsa-mir-21 Acute Kidney Injury CONCLUSIONS: ADSC-EVs inhibited inflammation and TEC pyroptosis and promoted TEC repair in AKI by mediating miR +lncRNA target 36244580 hsa-mir-709 Reperfusion Injury, Cerebral Ischemia CONCLUSION: Ligustrazine targets circ_0008146/miR-709/Cx3cr1 axis to inhibit cell apoptosis and inflammation after cerebral ischemia/reperfusion injury. +other 36244127 hsa-mir-223 Endometriosis Given the fact that miRNA-223 was previously shown to be upregulated in these cells and that this upregulation has been linked to epithelial-to-mesenchymal transition (EMT) during endometriosis, this study aimed to further explore the expression of miRNA-223, its effect in endometriosis, and the mechanisms underlying its effects. CONCLUSION: miRNA-223 expression decreased in endometrial SCs from endometriosis patients, which may facilitate the differential regulation of EMT during endometriosis. +other 36243928 hsa-mir-218 Pulmonary Disease, Chronic Obstructive The underexpression of miR-146a and miR-218 in COPD patients and relation to CSE can be indicative of CSE-induced changes in miRNA expression profile and potential for these biomarkers in COPD risk assessment, particularly in those patients with CSE. +other 36243928 hsa-mir-146a Pulmonary Disease, Chronic Obstructive The underexpression of miR-146a and miR-218 in COPD patients and relation to CSE can be indicative of CSE-induced changes in miRNA expression profile and potential for these biomarkers in COPD risk assessment, particularly in those patients with CSE. +genetics_overexpression_suppress 36243896 hsa-mir-486 Colorectal Neoplasms In CRC cell lines, demethylation and overexpression of miR +genetics_overexpression_suppress 36243896 hsa-mir-34c Colorectal Neoplasms In CRC cell lines, demethylation and overexpression of miR +lncRNA target 36243865 hsa-mir-610 Ovarian Neoplasms This study further demonstrated that circ_0000144 downregulated ELK3 levels by sponging miR-610 in ovarian cancer cells. CONCLUSION: Our data indicate that circ_0000144 could enhance the carcinogenesis of ovarian cancer by specifically targeting miR-610, which may serve as a novel target for the diagnosis and prognosis of ovarian cancer. +exosome 36243800 hsa-mir-140 Ossification of Posterior Longitudinal Ligament CONCLUSIONS: We found that exosomal miR +lncRNA target 36243708 hsa-mir-124 Cartilage Diseases 3p reduced MALAT1 stability and inhibited the binding of MALAT1 and KLF5 to downregulate CXCL11, thereby suppressing chondrocyte pyroptosis and cartilage injury in OA. +lncRNA target 36243708 hsa-mir-124 Osteoarthritis 3p reduced MALAT1 stability and inhibited the binding of MALAT1 and KLF5 to downregulate CXCL11, thereby suppressing chondrocyte pyroptosis and cartilage injury in OA. +other 36243683 hsa-let-7a Esophageal Squamous Cell Carcinoma The decrease in let-7a expression level led to the increased expression level of CCR7 in ESCC cells, consequently increasing their invasive ability and malignancy and resulting in a worse prognosis for ESCC patients. +lncRNA target 36243115 hsa-mir-186 Carcinoma, Hepatocellular miR-186 was significantly lower while IGF2BP1 was elevated in cancerous tissues from ten HCC patients compared to five healthy controls. SIGNIFICANCE: miR-186 may exert tumor suppressor effects in HCC by repressing oncogenic lncRNAs H19, SNHG3, and FOXD2-AS1 through its effect on IGF2BP1. +lncRNA target 36242967 hsa-mir-93 Acute Lung Injury Collectively, lncRNA MEG3 inhibition blocked TLR4/MyD88/NF-kappaB pathway to repress the progression of sepsis-induced lung injury via upregulating miR-93, implying that lncRNA MEG3 might be a viable therapeutic target for ALI. +lncRNA target 36242967 hsa-mir-93 Sepsis Collectively, lncRNA MEG3 inhibition blocked TLR4/MyD88/NF-kappaB pathway to repress the progression of sepsis-induced lung injury via upregulating miR-93, implying that lncRNA MEG3 might be a viable therapeutic target for ALI. +lncRNA target 36242914 hsa-mir-23a Achard-Thiers syndrome Hnf4alphaos also promoted the stability of Hnf4alpha mRNA through an RNA/RNA duplex, leading to the transcriptional activation of miR-23a and miR-23a depletion was required for PGC1alpha function in hepatoprotective effects on HIRI. Together, our findings reveal that Hnf4alphaos elevation in HIRI leads to severe liver damage via Hnf4alphaos/Hnf4alpha/miR-23a axis-mediated PGC1alpha inhibition. +genetics_knock down_promote 36242728 hsa-mir-186 Carcinoma, Hepatocellular 5p-mediated anti-tumor effects in HCC cells, whereas KLF7 knockdown reversed the promotive effects of NUTM2A-AS1. +other 36242602 hsa-mir-146a Polycythemia Vera Thrombotic risk did not depend on JAK2 rs12343867, TERT rs2736100, OBFC1 rs9420907 SNV, however, we found a novel strong tendency towards statistical significance between the CC genotype miR-146a rs2431697 and thrombosis. +lncRNA target 36242511 hsa-mir-130a Renal Tubular Oxidative Injury When we simultaneously inhibited NEAT1 and miR-130, renal tubular injury was exacerbated. +lncRNA target 36242511 hsa-mir-130 Renal Tubular Oxidative Injury When we simultaneously inhibited NEAT1 and miR-130, renal tubular injury was exacerbated. +circRNA target 36242088 hsa-mir-338 Osteoarthritis CONCLUSION: Circ_0008365 alleviates IL-1beta-induced CHON-001 cell damage through the miR3p/SOX9 axis, which suggested that circ_0008365 might be a new therapeutic target for OA. +circRNA target 36241975 hsa-mir-182 Carcinoma, Hepatocellular CONCLUSIONS: Taken together, circ_0003570 suppresses the development of HCC by modulating miR5p/STARD13 axis. +circulation_biomarker_diagnosis_ns 36241060 hsa-mir-145 Acute Coronary Syndrome In conclusion, plasma miR-143 and miR-145 levels can be used as noninvasive biomarkers for evaluating coronary artery stenosis. +circulation_biomarker_diagnosis_ns 36241060 hsa-mir-145 Coronary Stenosis In conclusion, plasma miR-143 and miR-145 levels can be used as noninvasive biomarkers for evaluating coronary artery stenosis. +circulation_biomarker_diagnosis_ns 36241060 hsa-mir-143 Coronary Stenosis In conclusion, plasma miR-143 and miR-145 levels can be used as noninvasive biomarkers for evaluating coronary artery stenosis. +circulation_biomarker_diagnosis_ns 36241060 hsa-mir-143 Acute Coronary Syndrome In conclusion, plasma miR-143 and miR-145 levels can be used as noninvasive biomarkers for evaluating coronary artery stenosis. +circRNA target 36241055 hsa-mir-1183 Triple Negative Breast Neoplasms We found that hsa_circ_0000851 bound directly to miR-1183, accelerating the expression of its target gene PDK1, which facilities BC cell proliferation and migration through PDK1/p-AKT. +lncRNA target 36240611 hsa-mir-155 Mucocutaneous Lymph Node Syndrome Through the relationships of TFs and hsa-miR +lncRNA target 36240130 hsa-mir-9 Diabetes Mellitus These studies showed a novel glucose-induced molecular mechanism in which ZFAS1 participates in the transcriptional regulation of ECM protein production in diabetes through miR-9. +lncRNA target 36240130 hsa-mir-9 Cardiomyopathies These studies showed a novel glucose-induced molecular mechanism in which ZFAS1 participates in the transcriptional regulation of ECM protein production in diabetes through miR-9. +lncRNA target 36240080 hsa-mir-134 Seizures These findings suggest that targeting miR-134 does not have therapeutic applications in DS. +transcription factor target 36239618 hsa-mir-155 Myocardial Reperfusion Injury Meanwhile, SL decreased miR-155 level, inhibited M1 macrophage polarization and inflammation. +lncRNA target 36239568 hsa-mir-936 Carcinoma, Non-Small-Cell Lung CONCLUSION: miR-936 targets GPR78 and improves the sensitivity of NSCLC cells to cisplatin via the Galphaq Rho GTPase pathway. +other 36239555 hsa-mir-516a Carcinoma, Hepatocellular PNPLA3 rs738409 GG carriers affect miR-516a-3P expression in HCV, and this may highlight a new mechanism in liver disease. +circulation_biomarker_diagnosis_ns 36239547 hsa-mir-4496 Esophageal Squamous Cell Carcinoma Next, EC cells were cocultured with EVs, followed by lentivirus transduction and plasmid transfection for studying the role of TEVs-AC116025.2 in EC cells in relation to miR-4496 and SEMA5A. +lncRNA target 36239525 hsa-mir-135a Colitis CONCLUSION: This study shows that circSMAD4 regulates the progression of experimental colitis via the miR-135a-5p/JAK2 signaling axis and it may be a potential therapeutic target. +lncRNA target 36238993 hsa-mir-143 Triple Negative Breast Neoplasms 3p could be potential therapeutic targets for TNBC. +genetics_overexpression_suppress 36238848 hsa-mir-5590 Carcinoma, Renal Cell Of note, overexpression of ROCK2 effectively reversed the regulatory effects of miR +target gene 36238844 hsa-mir-29a Carcinoma, Non-Small-Cell Lung miR-29a-3p inhibits the malignant characteristics of non-small cell lung cancer cells by reducing the activity of the Wnt/β-catenin signaling pathway. +other 36238488 hsa-mir-494 Osteosarcoma 3p, and TRPS1 might be a characteristic molecule for assessing the prognostic value of OS patients. +other 36238484 hsa-mir-146a Campomelia Cumming type After ECT treatment, the cognitive impairment was ameliorated in CUMS rats accomplished with decreased miR-146a-5p and increased NF-kappaB level. +lncRNA target 36238484 hsa-mir-146a Neurotic Disorders Finally, compared with ECT treatment, DEX injection could protect against depression-like behaviors by increasing miR-146a-5p level and inactivated NF-kappaB pathway. Overall, ECT-induced cognitive impairment in depression rats could be ameliorated by DEX injection via miR-146a-5p/NF-kappaB axis. +genetics_GWAS 36238483 hsa-mir-204 Diabetic Retinopathy 5p in order to participate in the pathogenetic process of DR. +lncRNA target 36238473 hsa-mir-223 Optic Nerve Glioma 3p plays an inhibitory role in ONG development by regulating NLRP3 to inhibit the proliferation of ONG cells and promote apoptosis. +other 36238196 hsa-mir-5120 Non-alcoholic Fatty Liver Disease CONCLUSION: Our data revealed the underlying mechanism by which Semaglutide improves hepatic steatosis in T2DM+NAFLD, and might shed new light on the pathological role of miR-5120/ABHD6 in the pathogenesis of T2DM+NAFLD. +other 36238196 hsa-mir-5120 Diabetes Mellitus, Type 2 CONCLUSION: Our data revealed the underlying mechanism by which Semaglutide improves hepatic steatosis in T2DM+NAFLD, and might shed new light on the pathological role of miR-5120/ABHD6 in the pathogenesis of T2DM+NAFLD. +circulation_biomarker_diagnosis_ns 36237545 hsa-mir-23b Colorectal Neoplasms Finally, miR-23b-3p, miR-301a-3p and miR3p were validated being the most stably expressed stage-associated miRNAs in CRC serum exosomes, cell exosomes and tissues. +circulation_biomarker_diagnosis_ns 36237545 hsa-mir-194 Colorectal Neoplasms Finally, miR-23b-3p, miR-301a-3p and miR3p were validated being the most stably expressed stage-associated miRNAs in CRC serum exosomes, cell exosomes and tissues. +other 36237258 hsa-mir-29c Squamous Cell Carcinoma of Head and Neck The ceRNA regulatory network MIR193BHG-miR-29c-3p-SFXN3 was identified as one of the potential biological regulatory pathways of HNSC. CONCLUSIONS: By performing ceRNA analysis, our study demonstrated that MIR193HG-miR-29c-3p-SFXN3 is significantly involved in HNSC, and this action axis markedly affect the therapeutic effect and prognosis. +genetics_GWAS 36237193 hsa-mir-146a Diabetes Mellitus, Type 2 CONCLUSION: The results of our study demonstrate that the miR-146a rs2910164 polymorphism might have ethnicity-dependent effects in T2DM and may be related to T2DM susceptibility in Caucasians. +transcription factor target 36237168 hsa-mir-690 Muscular Atrophy CONCLUSIONS: Our study demonstrated that atrophic muscle fibre-derived sEV miR-690 may inhibit satellite cell differentiation by targeting myocyte enhancer factor 2 during ageing. +transcription factor target 36237168 hsa-mir-690 Aicardi-Goutieres syndrome 5 CONCLUSIONS: Our study demonstrated that atrophic muscle fibre-derived sEV miR-690 may inhibit satellite cell differentiation by targeting myocyte enhancer factor 2 during ageing. +lncRNA target 36234731 hsa-mir-125b Glioma To solve this problem, we co-encapsulated DOX and endogenous tumor suppressor miR-125b into nanoparticles (NPs) by nanoprecipitation methods, and passively targeted them into glioma cells. In vitro experiments show that miR-125b and DOX can be effectively encapsulated into nanoparticles with different ratios, and by targeting YES proto-oncogene 1 (YES1), they can affect the adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK)/p53 pathway and induce brain glioma cell apoptosis. +genetics_overexpression_suppress 36233263 hsa-mir-26a Pulmonary Arterial Hypertension 5p or overexpression of miR-26a-5p in hPAECs post-exposure of PAH EVs abrogated proangiogenic and proliferative effects posed by PAH EVs contrary to HC EVs. +genetics_overexpression_suppress 36233263 hsa-mir-486 Pulmonary Arterial Hypertension 5p or overexpression of miR-26a-5p in hPAECs post-exposure of PAH EVs abrogated proangiogenic and proliferative effects posed by PAH EVs contrary to HC EVs. +lncRNA target 36233075 hsa-mir-203 Breast Neoplasms Notably, miR-203 and Caveolin 1 (CAV1) have also been found to play a role in breast cancer. In this study, we present a new mechanic through bioinformatics tool and basic experiments: the HOTAIR/miR-203/CAV1 axis, which complemented the role network of HOTAIR as a ceRNA, thus, it will provide a novel potential idea for breast cancer research and therapy. +lncRNA target 36232922 hsa-mir-139 Colorectal Neoplasms 3p-transfected cells revealed 29 putative targets regulated by miR +other 36232660 hsa-mir-199a Breast Neoplasms Two of the most significantly upregulated microRNAs, miR-199a-3p and miR-151a-3p, were strongly correlated with the onset of lymphedema and diabetes mellitus in the BCRL group. +other 36232660 hsa-mir-151a Arm Lymphedema Two of the most significantly upregulated microRNAs, miR-199a-3p and miR-151a-3p, were strongly correlated with the onset of lymphedema and diabetes mellitus in the BCRL group. +other 36232660 hsa-mir-199a Arm Lymphedema Two of the most significantly upregulated microRNAs, miR-199a-3p and miR-151a-3p, were strongly correlated with the onset of lymphedema and diabetes mellitus in the BCRL group. +other 36232660 hsa-mir-151a Breast Neoplasms Two of the most significantly upregulated microRNAs, miR-199a-3p and miR-151a-3p, were strongly correlated with the onset of lymphedema and diabetes mellitus in the BCRL group. +lncRNA target 36232606 hsa-mir-221 Carcinoma, Hepatocellular The miR-221/AEG-1 axis silencing induces apoptosis and G2/M phase arrest and inhibits cellular proliferation and angiogenesis by upregulating p57, p53, RB, and PTEN and downregulating LSF, LC3A, Bcl-2, OPN, MMP9, PI3K, and Akt in HCC cells. +other 36232605 hsa-mir-140 Carcinoma, Non-Small-Cell Lung 3p) were obtained. +other 36232605 hsa-mir-708 Carcinoma, Non-Small-Cell Lung 3p) were obtained. +other 36232605 hsa-mir-183 Carcinoma, Non-Small-Cell Lung 3p) were obtained. +other 36232605 hsa-mir-766 Carcinoma, Non-Small-Cell Lung 3p) were obtained. +genetics_GWAS 36232465 hsa-mir-166 Plant Poisoning qRT-PCR analysis of 29 related genes suggested that defects of the OsDRB2-miR166-OsHBs pathway could play an important role in formation of the rolled leaf phenotype of rl89, in which OsDRB2 mutation reduced miR166 accumulation, resulting in elevated expressions of the class III homeodomain-leucine zipper genes (such as OsHB1, 3 and 5) involved in leaf polarity and/or morphology development. +other 36232448 hsa-mir-181a Glioma Therefore, miR-181a is a unique molecule that plays an important role in gliomagenesis, and is also associated with changes in patients' quality of life. +other 36231141 hsa-mir-100 Stiff-Person Syndrome Endo-EVs cargo contained miR-100, miR-132, and miR-155, together with the mRNAs of porcine endogenous retrovirus (PERV) and beta-catenin. Moreover, the expression of miR-100, miR-132, and the mRNA transcripts of BCL2, zinc finger E-box-binding homeobox 1, beta-catenin, interferon-gamma, protein tyrosine phosphatase non-receptor type 1, PERV, and cyclin-dependent kinase 2 were all increased in embryos supplemented with Endo-EVs RI compared to those in the control group. +transcription factor target 36231141 hsa-mir-155 Stiff-Person Syndrome Endo-EVs cargo contained miR-100, miR-132, and miR-155, together with the mRNAs of porcine endogenous retrovirus (PERV) and beta-catenin. Targeting PERV with CRISPR/Cas9 resulted in reduced expression of PERV mRNA transcripts and increased miR-155 in the Endo-EVs, and supplementing these in embryos reduced embryo attachment. +other 36231141 hsa-mir-132 Stiff-Person Syndrome Endo-EVs cargo contained miR-100, miR-132, and miR-155, together with the mRNAs of porcine endogenous retrovirus (PERV) and beta-catenin. Moreover, the expression of miR-100, miR-132, and the mRNA transcripts of BCL2, zinc finger E-box-binding homeobox 1, beta-catenin, interferon-gamma, protein tyrosine phosphatase non-receptor type 1, PERV, and cyclin-dependent kinase 2 were all increased in embryos supplemented with Endo-EVs RI compared to those in the control group. +circulation_biomarker_diagnosis_up 36231079 hsa-mir-34a Cardiomegaly Prior work had also shown that circulating or cardiac miR-34a was elevated in a setting of diabetes. +circulation_biomarker_diagnosis_up 36231079 hsa-mir-34a Pulmonary Fibrosis Prior work had also shown that circulating or cardiac miR-34a was elevated in a setting of diabetes. +circulation_biomarker_diagnosis_up 36231079 hsa-mir-34a Diabetic Cardiomyopathies Prior work had also shown that circulating or cardiac miR-34a was elevated in a setting of diabetes. +lncRNA target 36231079 hsa-mir-92a Pulmonary Fibrosis Inhibition of miR-34a had no significant effect on diastolic function or atrial enlargement, but had a mild effect on preventing an elevation in cardiac enlargement, fibrosis and ventricular gene expression of B-type natriuretic peptide (BNP) and the anti-angiogenic miRNA (miR-92a). +lncRNA target 36231079 hsa-mir-92a Cardiomegaly Inhibition of miR-34a had no significant effect on diastolic function or atrial enlargement, but had a mild effect on preventing an elevation in cardiac enlargement, fibrosis and ventricular gene expression of B-type natriuretic peptide (BNP) and the anti-angiogenic miRNA (miR-92a). +lncRNA target 36231079 hsa-mir-92a Diabetic Cardiomyopathies Inhibition of miR-34a had no significant effect on diastolic function or atrial enlargement, but had a mild effect on preventing an elevation in cardiac enlargement, fibrosis and ventricular gene expression of B-type natriuretic peptide (BNP) and the anti-angiogenic miRNA (miR-92a). +other 36231008 hsa-mir-210 Diabetes Mellitus, Type 2 5p). +other 36231008 hsa-mir-210 Obesity, Morbid 5p). +other 36231008 hsa-mir-206 Obesity, Morbid 5p). +other 36231008 hsa-mir-206 Diabetes Mellitus, Type 2 5p). +other 36230970 hsa-mir-93 Colorectal Neoplasms CONCLUSION: In summary, our result reveals the novel mechanism in which m(6)A-mediated HNF1A-AS1/IGF2BP2/CCND1 axis promotes CRC cell cycle progression, along with competitively sponging miR5p to upregulate CCND1, demonstrating its significant role in cell cycle regulation and suggesting that HNF1A-AS1 may act as a potential prognostic marker of colorectal cancer in the future. +circulation_biomarker_diagnosis_up 36230923 hsa-mir-17 Pneumonia 5p and miR-193a-5p in EVs may be involved in lung inflammation by influencing the forkhead box O (FoxO) signaling pathway and protein processing in endoplasmic reticulum. +circulation_biomarker_diagnosis_up 36230923 hsa-mir-193a Pneumonia 5p and miR-193a-5p in EVs may be involved in lung inflammation by influencing the forkhead box O (FoxO) signaling pathway and protein processing in endoplasmic reticulum. +circulation_biomarker_diagnosis_up 36230658 hsa-mir-34a Carcinoma, Non-Small-Cell Lung We analyzed the expression levels and examined the clinical significance of immunoregulatory miRNAs involved in immune checkpoint regulation (miR-34a, miR-200b, miR-200c), T-cell activity (miR-155), and the function of myeloid-derived suppressive cells (MDSCs) (miR-223) or regulatory T lymphocytes (Tregs) (miR-146a), in patients with advanced NSCLC (N = 69) treated with anti-PD-1 (Nivolumab) immunotherapy as 2nd or 3rd line of treatment therapy. Our findings suggest that alterations in circulating miR-200c and miR-34a expression levels are associated with the response and outcome in patients with advanced NSCLC treated with anti-PD1 immunotherapy. +other 36229758 hsa-mir-660 Carcinoma, Non-Small-Cell Lung Circ_0060967 facilitates proliferation, migration, and invasion of non-small-cell lung cancer cells by sponging miR-660-3p/UBN2. +circulation_biomarker_diagnosis_down 36229729 hsa-mir-147b Leukemia, Myeloid, Acute miR-147b was negatively correlated with MAFG-AS1 in the serum and bone narrow of AML cases. +circulation_biomarker_diagnosis_ns 36229645 hsa-mir-483 Lung Neoplasms 3p derived from plasma sEVs could be used as a potential biomarker for the diagnosis of early-stage SCLC, miRNA +circulation_biomarker_diagnosis_ns 36229645 hsa-mir-1277 Lung Neoplasms 3p derived from plasma sEVs could be used as a potential biomarker for the diagnosis of early-stage SCLC, miRNA +circulation_biomarker_diagnosis_ns 36229645 hsa-mir-152 Lung Neoplasms 3p derived from plasma sEVs could be used as a potential biomarker for the diagnosis of early-stage SCLC, miRNA +other 36228560 hsa-mir-21 Mucocutaneous Lymph Node Syndrome Moreover, the proposed MLN-MB could detect the miRNA-21 in complex matrixes stably. +genetics_overexpression_suppress 36228497 hsa-mir-135a Breast Neoplasms Overexpression of BAG3 reversed the impacts of miR-135a-5p on the malignant biological behaviors of BC cells. +lncRNA target 36228430 hsa-mir-155 Influenza in Birds In this study, miR-155, a key factor in the regulation of immune function, was selected to study its expression, potential function and mechanism in the 12-day-old chicken immune responses to three vaccines (avian influenza virus inactivated vaccine, Newcastle disease virus attenuated vaccine and infectious bursal disease virus attenuated vaccine), respectively. +lncRNA target 36228430 hsa-mir-155 Newcastle Disease In this study, miR-155, a key factor in the regulation of immune function, was selected to study its expression, potential function and mechanism in the 12-day-old chicken immune responses to three vaccines (avian influenza virus inactivated vaccine, Newcastle disease virus attenuated vaccine and infectious bursal disease virus attenuated vaccine), respectively. +lncRNA target 36228430 hsa-mir-155 Bursitis In this study, miR-155, a key factor in the regulation of immune function, was selected to study its expression, potential function and mechanism in the 12-day-old chicken immune responses to three vaccines (avian influenza virus inactivated vaccine, Newcastle disease virus attenuated vaccine and infectious bursal disease virus attenuated vaccine), respectively. +circulation_biomarker_diagnosis_up 36228356 hsa-mir-221 Depression 3p in the hippocampus and serum of O(3) treated group. +other 36228348 hsa-let-7 Head and Neck Neoplasms In this study, we aimed to investigate polymorphic alterations of the let-7 miRNA binding site (rs61764370) in the 3'UTR region of the KRAS gene as a predictive biomarker for head and neck cancer (HNC) and to evaluate its association with clinicopathological parameters. +epigenetics 36228259 hsa-mir-130b Pediatric Obesity Therefore, we aimed to examine the expression levels of obesity-related MicroRNA-130b and MicroRNA-146b and the methylation status of hypoxia factor 3A and interleukin-6 genes associated with obesity in children. +epigenetics 36228259 hsa-mir-146b Pediatric Obesity Therefore, we aimed to examine the expression levels of obesity-related MicroRNA-130b and MicroRNA-146b and the methylation status of hypoxia factor 3A and interleukin-6 genes associated with obesity in children. +lncRNA target 36227683 hsa-mir-19a Cerebral Infarction, Acute Furthermore, our conclusions provide further insights on the interplay among TALNEC2, miR-19a-3p and JNK in cerebral infarction. It has demonstrated herein that TALNEC2 positively modulates JNK post-transcriptional expression through miR-19a-3p sponging in cerebral Infarction offering a novel therapy target for cerebral infarction. +lncRNA target 36227683 hsa-mir-19a Brain Ischemia Furthermore, our conclusions provide further insights on the interplay among TALNEC2, miR-19a-3p and JNK in cerebral infarction. It has demonstrated herein that TALNEC2 positively modulates JNK post-transcriptional expression through miR-19a-3p sponging in cerebral Infarction offering a novel therapy target for cerebral infarction. +circulation_biomarker_diagnosis_ns 36227679 hsa-mir-146a Depression, Post Stroke Compared with that of N-PSD patients, serum miR-146a-5p levels in PSD patients were significantly increased (P<0.05). +lncRNA target 36227673 hsa-mir-194 Laryngeal Neoplasms 5p could reduce the number of laryngeal cancer cells passing through the basement membrane and their invasion ability. +other 36227666 hsa-mir-34a Neuroblastoma This work was to study the regulatory mechanism of large intergenic non-coding RNA 0196 (LINC0196), miR5p, miR-34a-5p, and tripartite motif 59 (TRIM59) on neuroblastoma. +other 36227666 hsa-mir-584 Neuroblastoma This work was to study the regulatory mechanism of large intergenic non-coding RNA 0196 (LINC0196), miR5p, miR-34a-5p, and tripartite motif 59 (TRIM59) on neuroblastoma. +circulation_biomarker_diagnosis_up 36227663 hsa-mir-7 Colorectal Neoplasms It was concluded that modulation of miR-7 in rats with colorectal cancer and HP infection enables regulation of the Akt / GSK-3 beta/beta- Catenin pathway to improve serum inflammation condition and alleviate HP infection in rats, which played a better role in intervention. +genetics_overexpression_promote 36227662 hsa-mir-889 Diabetes, Gestational The high glucose-induced human trophoblast cells HTR-8/SVneo were adopted to stimulate the GDM model in vitro (HG group) and were transfected with lentivirus to silence circ-PNPT1 (si-circ-PNPT1 group) and mimic to overexpress miR +circRNA target 36227499 hsa-mir-134 Thyroid Cancer, Papillary 5p served as a tumor repressor in PTC by targeting FSTL1. +transcription factor target 36227355 hsa-mir-181c Sepsis CONCLUSIONS: Our results demonstrated that miR-181c could suppress TLR4 expression, reduce inflammatory factor and chemokine secretion, mitigate inflammatory cell infiltration into the kidney and downregulate KIM-1 expression, which might ultimately attenuate burn sepsis-induced AKI. +transcription factor target 36227355 hsa-mir-181c Acute Kidney Injury CONCLUSIONS: Our results demonstrated that miR-181c could suppress TLR4 expression, reduce inflammatory factor and chemokine secretion, mitigate inflammatory cell infiltration into the kidney and downregulate KIM-1 expression, which might ultimately attenuate burn sepsis-induced AKI. +transcription factor target 36227355 hsa-mir-181c Burns CONCLUSIONS: Our results demonstrated that miR-181c could suppress TLR4 expression, reduce inflammatory factor and chemokine secretion, mitigate inflammatory cell infiltration into the kidney and downregulate KIM-1 expression, which might ultimately attenuate burn sepsis-induced AKI. +genetics_knock down_suppress 36227295 hsa-mir-484 Kidney Calculi Taken together, these findings suggest that miR-484 overexpression may be a potential inhibitor of RTEC proliferation and CaOx crystallization through a VDR/FoxO1 regulatory axis, providing a novel therapeutic target for the treatment of kidney stone. +lncRNA target 36227173 hsa-mir-22 Vascular Diseases These findings suggested that PA inhibits VSMC switch to synthetic phenotype through upregulation of miR-22 thereby inhibiting EVI1, and correcting the dysregulation of miR-22/EVI1 or PA metabolism is a potential treatment to vascular diseases. +other 36227151 hsa-mir-101 Adenocarcinoma of Lung The most promising upstream ncRNA-associated pathway of KIF14 in LUAD was determined to be GSEC/TYMSOS-hsa-miR3p axis according to the starBase and The Cancer Genome Atlas databases. +other 36227125 hsa-mir-422a Glioma In this study, based on the glioblastoma microarray profiles, we identified the upstream circTOP2A, which completely bound to miR-422a and was co-expressed with the RPN2. +other 36227097 hsa-mir-200c Diabetic Nephropathies The results implicate a miR-379/EDEM3/ER stress/miR-200c/Zeb2 signaling pathway in HFD/obesity/insulin resistance-induced renal dysfunction. +other 36227097 hsa-mir-200 Diabetic Nephropathies The results implicate a miR-379/EDEM3/ER stress/miR-200c/Zeb2 signaling pathway in HFD/obesity/insulin resistance-induced renal dysfunction. +exosome 36226722 hsa-let-7b Ovarian Neoplasms We performed coculture experiments using ID8-VEGF ovarian cancer cells to demonstrate EV-mediated propagation of tumor suppressor miRNA Let7b administered with hyaluronic acid-poly(ethyleneimine) (HA-PEI) nanoparticles. +lncRNA target 36226520 hsa-mir-486 Gaucher Disease 5p inhibits GA inflammatory response via modulating FOXO1. +other 36226317 hsa-mir-211 Cerebral Hemorrhage BCL2L13 axes were indicated to participate in the immune regulatory mechanism of ICH. +other 36226317 hsa-mir-198 Cerebral Hemorrhage BCL2L13 axes were indicated to participate in the immune regulatory mechanism of ICH. +lncRNA target 36226250 hsa-mir-1271 Uterine Cervical Neoplasms Overall, this study showed that FAM201A promoted cervical cancer progression and metastasis by targeting the miR5p/FLOT1 axis-induced Wnt/beta-catenin pathway. +transcription factor target 36225912 hsa-mir-10a Acquired Immunodeficiency Syndrome Thus, inhibition of miR-10a-5p enhanced HIV-specific CD8(+) T cell capacity in progressors. +transcription factor target 36225178 hsa-mir-505 Myocarditis In this study, miR5p is related to MIRI pathogenesis, which provides the new possible targeted therapy in patients with MIRI. +virus_miRNA 36225172 ebv-mir-BART5 Nasopharyngeal Carcinoma Inhibiting expression of EBV-miR-BART5-3p might reduce the risk of developing nasopharyngeal cance +lncRNA target 36224673 hsa-mir-3679 Carcinoma, Hepatocellular Moreover, miRNA-3679 promotes the proliferation of HCC cells and inhibits their apoptosis by suppressing ZADH2. +lncRNA target 36224588 hsa-mir-155 Colonic Neoplasms CONCLUSION: Our findings demonstrate that circPPFIA1s inhibit the liver metastasis of CRC via the miR5p/CDX1 and HuR/RAB36 pathways. +lncRNA target 36224570 hsa-mir-4306 Hypertrophy Of Ligamentum Flavum CONCLUSIONS: Our study demonstrated that TCF7 inhibition could suppress HLF formation by modulating TCF7/SNAI2/miR-4306 feedback loop, which might be considered as a novel potential therapeutic target for HLF. +lncRNA target 36224570 hsa-mir-4036 Hypertrophy Of Ligamentum Flavum Furthermore, miR-4036 negatively regulated by SNAI2 could negatively feedback regulate TCF7 expression by directly binding to TCF7 mRNA 3'-UTR, thus inhibiting the hyper-proliferation and fibrosis phenotype of HLF cells in vitro. +genetics_GWAS 36224531 hsa-mir-19b Endothelial Barrier Dysfunction METHOD: Human lung microvascular endothelial cells (HLMEC) or HEK293T cells were transfected with c-Jun overexpressing vector, c-Jun siRNA, miR-19b promoter vector, miR-19b mutated promoter vector, miR-19b oligo inhibitor, then subjected to hypoxia/reoxygenation as in-vitro model of hemorrhagic shock. +genetics_GWAS 36224531 hsa-mir-19b Shock, Hemorrhagic METHOD: Human lung microvascular endothelial cells (HLMEC) or HEK293T cells were transfected with c-Jun overexpressing vector, c-Jun siRNA, miR-19b promoter vector, miR-19b mutated promoter vector, miR-19b oligo inhibitor, then subjected to hypoxia/reoxygenation as in-vitro model of hemorrhagic shock. +other 36224455 hsa-mir-1226 Nasopharyngeal Neoplasms Our results demonstrated the novel function of TUC338/miR3p/FGF2 axis in NPC progression, suggesting the potential diagnosis and therapeutics significance of TUC338 in NPC. +genetics_overexpression_promote 36224454 hsa-mir-671 Thyroid Cancer, Papillary 5p, and its overexpression relieved miR +lncRNA target 36224266 hsa-mir-145 Laryngeal Neoplasms 5p (mean rank 1.57 vs 2.15 vs 2.28, p = 0.000) were significantly dysregulated in peritumor mucosa with a pattern of expression consistent with paired tumor samples thus revealing a signature of field cancerization in laryngeal carcinoma. +lncRNA target 36224266 hsa-mir-144 Laryngeal Neoplasms 5p (mean rank 1.57 vs 2.15 vs 2.28, p = 0.000) were significantly dysregulated in peritumor mucosa with a pattern of expression consistent with paired tumor samples thus revealing a signature of field cancerization in laryngeal carcinoma. +genetics_overexpression_promote 36224238 hsa-mir-936 Prostatic Neoplasms Furthermore, the overexpression of miR-936 suppresses the cell proliferation, cell cycle progression, cell migration, and invasion abilities of metastatic PCa PC-3 cells in vitro and tumor forming ability in vivo. +exosome 36224178 hsa-let-7a Liver Injury Altogether, these findings revealed that the hepatoprotective effect of MSCs may partially profit from its exosomal let-7a-5p mediating autophagy repairment, which may provide new insights for the therapeutic target of ACLF treatment. +exosome 36224178 hsa-let-7a Acute-On-Chronic Liver Failure Altogether, these findings revealed that the hepatoprotective effect of MSCs may partially profit from its exosomal let-7a-5p mediating autophagy repairment, which may provide new insights for the therapeutic target of ACLF treatment. +exosome 36224027 hsa-mir-22 Melanoma Moreover, exosomes secreted by MSCs can be loaded with miR +exosome 36224011 hsa-let-7c Prostatic Neoplasms, Castration-Resistant CONCLUSIONS: MSC-derived exosomes could serve as a therapeutic let-7c delivery system to target CRPC. +exosome 36223498 hsa-mir-25 Lupus Nephritis Urinary exosomal miR +exosome 36223498 hsa-mir-195 Lupus Nephritis CONCLUSION: We analyzed and obtained a series of differential miRNAs in LN kidney tissues and suggested that urinary exosomal miR +exosome 36223498 hsa-mir-429 Lupus Nephritis Urinary exosomal miR +lncRNA target 36222958 hsa-mir-205 Depression Thus, MA may ameliorate depressive behavior through CREB/BDNF pathway regulated by miR-205/Cx43 axis. +exosome 36222945 hsa-mir-655 Esophageal Squamous Cell Carcinoma OBJECTIVE: This study clarified the function of human umbilical cord mesenchymal stem cell (hUCMSC)-derived extracellular vesicle (EV)-enclosed miR +transcription factor target 36222901 hsa-mir-199a Colitis plantarum supplementation also suppressed CD44 expression (1.2 fold) by up regulating the expression of miR199a (1 fold) over DSS induced colitis. Our study suggests that Lactobacillus, lignin, and their synergistic treatments have protective roles against inflammatory bowel disease through changes in inflammatory cytokines, and miR 199a expression in DSS-induced colitis. +other 36222338 hsa-mir-143 Lung Neoplasms We also observed significantly increased expression of miR-143 and miR-145 at the distant metastasis stage, and significantly decreased expression of miR-133a in the N2 disease group of lung carcinoma patients (N2 disease represents disease with metastases in the ipsilateral mediastinal and/or subcarinal lymph nodes or node). +other 36222338 hsa-mir-133a Lung Neoplasms We also observed significantly increased expression of miR-143 and miR-145 at the distant metastasis stage, and significantly decreased expression of miR-133a in the N2 disease group of lung carcinoma patients (N2 disease represents disease with metastases in the ipsilateral mediastinal and/or subcarinal lymph nodes or node). +other 36222338 hsa-mir-145 Lung Neoplasms We also observed significantly increased expression of miR-143 and miR-145 at the distant metastasis stage, and significantly decreased expression of miR-133a in the N2 disease group of lung carcinoma patients (N2 disease represents disease with metastases in the ipsilateral mediastinal and/or subcarinal lymph nodes or node). +circRNA target 36222337 hsa-mir-124 Siderosis Both UII and ferroptosis inducer Erastin significantly promoted the expression of alpha-SMA, Collagen I and TGF-beta1 in VAFs, but circ0004372 siRNA, miR-124 mimics, SERTAD4 siRNA or Ferrostatin-1 significantly inhibited the effect of UII and Erastin on cell activation. Therefore, these results indicate that UII promotes the activation of VAFs through the circ0004372/miR-124/SERTAD4/ferroptosis pathway. +genetics_overexpression_promote 36222159 hsa-mir-1299 Carcinoma, Hepatocellular MiR-1299 mimics, ZC3H13 overexpression or GBX2 siRNA significantly inhibited HCC cell viability, promoted apoptosis and reduced invasion; GBX2 exerted the opposite effects and could reverse the regulatory effects of miR-1299 or ZC3H13 on HCC cells. +lncRNA target 36221890 hsa-mir-367 Lung Neoplasms 3p/TFRC pathway via resibufogenin might provide novel therapeutic targets for lung cancer therapy. +lncRNA target 36221434 hsa-mir-218 Pheochromocytoma 5p and toll-like receptors (TLR4) level were examined by both quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting, the potential target genes of miR +other 36221429 hsa-mir-4748 Pulmonary Disease, Chronic Obstructive Moreover, hsa-miR-4748/CDC42/MAPK signaling pathway may contribute to the pathogenesis of COPD, providing a potential novel therapeutic strategy in COPD. +lncRNA target 36221381 hsa-mir-181c Frontotemporal Lobar Degeneration In FTD, SEV miRNA-181c was downregulated compared to healthy controls. SEV miRNA-181c is significantly downregulated in FTD compared to healthy controls and may mediate its effects through microglial-directed neuroinflammation and interaction with TAR DNA-binding protein 43 (TDP-43) based on pathway analysis. +circulation_biomarker_diagnosis_up 36221381 hsa-mir-21 Frontotemporal Lobar Degeneration Using an FDR <0.2, only miRNA5p was found to have increased expression in the cerebrospinal fluid compared to plasma in a group of AD and FTD participants. +exosome 36221294 hsa-mir-214 Myocardial Infarction Pathway interaction network analysis further indicated that exosomal has_circ_0061776 was associated with has-miR-133a, has-miR-214, has-miR-423, and has-miR-217 and may play a role in the pathogenesis of AMI through the MAPK signaling pathway. +exosome 36221294 hsa-mir-217 Myocardial Infarction Pathway interaction network analysis further indicated that exosomal has_circ_0061776 was associated with has-miR-133a, has-miR-214, has-miR-423, and has-miR-217 and may play a role in the pathogenesis of AMI through the MAPK signaling pathway. +exosome 36221294 hsa-mir-423 Myocardial Infarction Pathway interaction network analysis further indicated that exosomal has_circ_0061776 was associated with has-miR-133a, has-miR-214, has-miR-423, and has-miR-217 and may play a role in the pathogenesis of AMI through the MAPK signaling pathway. +exosome 36221294 hsa-mir-133a Myocardial Infarction Pathway interaction network analysis further indicated that exosomal has_circ_0061776 was associated with has-miR-133a, has-miR-214, has-miR-423, and has-miR-217 and may play a role in the pathogenesis of AMI through the MAPK signaling pathway. +lncRNA target 36221121 hsa-mir-223 Periodontitis CONCLUSIONS: Our study provides novel evidence that miR-223 can be induced by periodontitis and acts as a negative regulator of PDL-derived cells osteogenesis by targeting two growth factor receptors (TGFbetaR2 and FGFR2). +other 36220723 hsa-mir-2909 Breast Neoplasms The emerging studies of miR-2909 involvement in other cancers led us to explore its role as molecular mechanistic marker in breast cancer. CONCLUSION: The results suggest that miR-2909 forms strong thermodynamically stable molecular hybridized complexes with MRE11 and RAD50 mRNAs which further strongly interacts with argonaute protein to show potential molecular mechanistic role in breast cancer. +genetics_GWAS 36219718 hsa-mir-340 Stomach Neoplasms PRACTICAL APPLICATIONS: Gastric cancer is the third leading cause of cancer death, and genetic and epigenetic factors, including miR-340, are involved in its pathogenesis. +circulation_biomarker_diagnosis_up 36219614 hsa-mir-221 Postoperative Cognitive Complications Our results indicate that the plasma postoperative microRNA +circulation_biomarker_diagnosis_ns 36219565 hsa-mir-21 Lung Neoplasms We introduce a nanophotonic biosensor for the direct and real-time detection in human plasma of the microRNA5p biomarker related to lung cancer. +circulation_biomarker_diagnosis_up 36219542 hsa-mir-23b Pancreatitis, Chronic However, the expression of plasma glutathione peroxidase (GPx3) in early-onset ICP patients was markedly lower than that in late-onset ICP patients, although the level of hsa-miR-323b-5p was lower in late-onset patients compared to the early-onset ICP group. CONCLUSIONS: The up-regulated hsa-miR-323b-5p might play a crucial role in the early-onset mechanisms of ICP by diminishing the antioxidant activity through the down-regulation of GPx3. +epigenetics 36219533 hsa-mir-106b Osteoporosis CONCLUSION: Hsa-miRNA-106b-5p regulates bone formation and the pathogenesis of osteoporosis by controlling TCF4, and methylation modification of TCF4 can also affect the pathogenesis of osteoporosis. +genetics_overexpression_promote 36219369 hsa-mir-485 Adenocarcinoma of Lung 5p overexpression in LUAD cells reduced their malignant behaviors, suppressed PI3K and Akt phosphorylation, and facilitated apoptosis. +target gene 36219357 hsa-mir-326 Colorectal Neoplasms upregulates the NFIB level via sponging miR-326 to promote oxaliplatin resistance and malignant progression of colorectal cancer cells. +lncRNA target 36219356 hsa-mir-491 Squamous Cell Carcinoma of Head and Neck In summary, we draw a conclusion that circMAT2B could modulate the processes of cell proliferation, migration, invasion, and glutaminolysis of HNSCC cells partly via the miR5p/ASCT2 axis by a molecular mechanism of competing endogenous RNA (ceRNA), implying an underlying circRNA-targeted therapy for HNSCC treatment. +genetics_knock down_promote 36219353 hsa-mir-92b Colonic Neoplasms We detected the expression of FEZF1-AS1, miR-92b-3p, and ZIC5 via quantitative reverse transcription-PCR, transfected colon cancer cell RKO with lentivirus and conducted FEZF1-AS1 knockdown, and performed cancer-related functional assays. +genetics_GWAS 36219319 hsa-mir-429 Glioblastoma CONCLUSIONS: Altogether, miR-429 seems to be an efficient suppressor of the ERBB genetic signaling pathway and a potential therapeutic for GBM. +transcription factor target 36217923 hsa-mir-23b Schizophrenia We observed significant enrichment of MBSVs in schizophrenia, depression, bipolar disorder, and anorexia nervosa, particularly in genes targeted by several miRNA families, including miR +other 36217395 hsa-mir-221 Prostatic Neoplasms CONCLUSIONS: TOPIIA, Ki-67 and miR-221 may not predict BCR, CR or PcD in high-risk PCa patients who underwent RP at a medium-term follow-up. +circulation_biomarker_diagnosis_ns 36217380 hsa-let-7f Pulmonary Fibrosis Of these, let-7f-5p showed reproducibly lower level in the blood and lung of the BIPF model rat, and the expression levels of PI3K/AKT/COX2 signaling pathway genes (PIK3CA, PDK1, Akt1, IKBKA, NF-kappaB1 and COX2) were increased in the lung of BIPF model rats, suggesting that there is a potential correlation between BIPF and the PI3K/AKT/COX2 signaling pathway. +other 36217202 hsa-mir-130b Neoplasms, Multiple Primary MiR-130b-3p levels were significantly upregulated and positively correlated with mTORC1 signaling in multiple cancers. +lncRNA target 36217202 hsa-mir-130b Squamous Cell Carcinoma of Head and Neck MiR-130b-3p inhibition attenuated tumor angiogenesis and growth in an HNSCC PDX model. +circulation_biomarker_prognosis_ns 36217165 hsa-mir-519a Stomach Neoplasms RESULTS: The expression level of miR-519a-3p in serum exosomes was significantly higher in GC-LM patients than in patients without LM, and high expression of exo-miR-519a-3p indicates a worse prognosis. +other 36216908 hsa-mir-193a Obesity The most significant association among the overlapping miRNAs was with miR-193a-5p, which was shown to be associated with type 2 diabetes and hepatic steatosis in the Rotterdam Study. +other 36216575 hsa-mir-17 Leukemia, Myelogenous, Chronic, BCR-ABL Positive The work uncovered a critical role of the c-MYC-miR92-BIM axis in the growth and survival of CML cells. +circulation_biomarker_diagnosis_ns 36216309 hsa-mir-33a Carcinoma, Hepatocellular Clinical scores (atherogenic indexes, atherosclerotic cardiovascular disease-ASCVD and systematic coronary risk evaluation-SCORE), biochemistry, miR-122, miR-33a, plasminogen activator inhibitor-1 (PAI-1), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), were determined before and after the intervention. +circulation_biomarker_diagnosis_ns 36216309 hsa-mir-122 Carcinoma, Hepatocellular Clinical scores (atherogenic indexes, atherosclerotic cardiovascular disease-ASCVD and systematic coronary risk evaluation-SCORE), biochemistry, miR-122, miR-33a, plasminogen activator inhibitor-1 (PAI-1), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), were determined before and after the intervention. +exosome 36216243 hsa-mir-361 Diabetes Mellitus In conclusion, our results indicated that in an H-glu environment, adipocyte exosomes damage microvascular endothelial cells via a LINC00968/miR5p/TRAF3 signaling pathway, which could possibly serve as a target for treating diabetes-obesity-triggered microvascular complications. +exosome 36216243 hsa-mir-361 Diabetic Angiopathies In conclusion, our results indicated that in an H-glu environment, adipocyte exosomes damage microvascular endothelial cells via a LINC00968/miR5p/TRAF3 signaling pathway, which could possibly serve as a target for treating diabetes-obesity-triggered microvascular complications. +exosome 36216243 hsa-mir-361 Obesity In conclusion, our results indicated that in an H-glu environment, adipocyte exosomes damage microvascular endothelial cells via a LINC00968/miR5p/TRAF3 signaling pathway, which could possibly serve as a target for treating diabetes-obesity-triggered microvascular complications. +circulation_biomarker_diagnosis_ns 36216207 hsa-mir-545 Pneumonia 3p), and tumor necrosis factor receptor-associated factor 1 (TRAF1) in neonatal pneumonia serums and LPS-treated 16HBE cells. +genetics_knock down_promote 36216119 hsa-mir-513a Esophageal Squamous Cell Carcinoma miR-513a-3p was verified as a specific target of BBOX1-AS1 in ESCC, whereas knockdown of miR-513a-3p reversed the suppressive function of BBOX1-AS1 silencing in TE-1 cells. +lncRNA target 36216078 hsa-mir-222 Aortic Dissection 3p alleviated the symptom of AD in vivo by targeting STAT3, and inhibited stress fiber formation, abnormal migration, proliferation and apoptosis of HVSMCs induced by PDGF-BB by regulating the expression of alpha-SMA, SM22alpha, MMP2, MMP9 and p-Smad2. +transcription factor target 36215851 hsa-mir-484 Dengue CONCLUSION: The miRNAs identified by sequencing, especially miR-484 may be the potential therapeutic targets for liver involvement in dengue patients which involves the regulation of vascular permeability and expression of inflammatory cytokines. +genetics_overexpression_suppress 36215729 hsa-mir-6838 Liver Neoplasms 6p was down-regulated in HCC tumors and overexpression of miR +genetics_overexpression_promote 36215729 hsa-mir-6838 Carcinoma, Hepatocellular 5p suppressed Hep3B xenograft tumor growth in vivo, while CBX4 overexpression abrogated the suppression effect, restored the angiogenesis, epithelial-to-mesenchymal transition (EMT), and ERK signaling in Hep3B tumor. +genetics_overexpression_promote 36215729 hsa-mir-6838 Hepatitis B, Chronic Overexpression of miR5p suppressed Hep3B xenograft tumor growth in vivo, while CBX4 overexpression abrogated the suppression effect, restored the angiogenesis, epithelial-to-mesenchymal transition (EMT), and ERK signaling in Hep3B tumor. +lncRNA target 36215225 hsa-let-7f Porcine Reproductive and Respiratory Syndrome The let-7 family miRNAs were significantly differentially expressed between PRRSV-infected and mock-infected PAMs from 4 pig breeds. The let-7 family miRNAs could significantly inhibit PRRSV-2 replication by directly targeting the 3'UTR of the PRRSV-2 genome and porcine IL6, which plays an important role in PRRSV replication and lung injury. +lncRNA target 36215225 hsa-let-7d Porcine Reproductive and Respiratory Syndrome The let-7 family miRNAs could significantly inhibit PRRSV-2 replication by directly targeting the 3'UTR of the PRRSV-2 genome and porcine IL6, which plays an important role in PRRSV replication and lung injury. +lncRNA target 36215225 hsa-let-7d Lung Injury The let-7 family miRNAs could significantly inhibit PRRSV-2 replication by directly targeting the 3'UTR of the PRRSV-2 genome and porcine IL6, which plays an important role in PRRSV replication and lung injury. +lncRNA target 36215225 hsa-let-7f Lung Injury The let-7 family miRNAs could significantly inhibit PRRSV-2 replication by directly targeting the 3'UTR of the PRRSV-2 genome and porcine IL6, which plays an important role in PRRSV replication and lung injury. +lncRNA target 36215225 hsa-let-7 Lung Injury The let-7 family miRNAs could significantly inhibit PRRSV-2 replication by directly targeting the 3'UTR of the PRRSV-2 genome and porcine IL6, which plays an important role in PRRSV replication and lung injury. +lncRNA target 36215225 hsa-let-7 Porcine Reproductive and Respiratory Syndrome The let-7 family miRNAs could significantly inhibit PRRSV-2 replication by directly targeting the 3'UTR of the PRRSV-2 genome and porcine IL6, which plays an important role in PRRSV replication and lung injury. +genetics_knock down_promote 36214997 hsa-mir-23b Stomach Neoplasms Loss of SNHG17 reduced the resistance of DDP-resistant GC cells to DDP, which was achieved through miR-23b-3p-dependent Notch2 inhibition. +circulation_biomarker_diagnosis_up 36214846 hsa-mir-451a Myocardial Infarction, Acute MHR and miR-451a expression were markedly elevated in plasma samples of AMI patients compared with the UAP and HC groups, but the expressions of miR +circulation_biomarker_diagnosis_ns 36214846 hsa-mir-21 Myocardial Infarction, Acute Circulating miR +circulation_biomarker_diagnosis_up 36214846 hsa-mir-486 Myocardial Infarction, Acute The results showed that circulating miR +other 36214767 hsa-mir-145 Carcinoma, Hepatocellular 5p or RGS3 furtherly indicated UBE2MP1 as an upstream regulator of the axis in promoting HCC cell growth and maintenance. +other 36214765 hsa-mir-143 Coronary Artery Disease In addition, miR-133, miR-21, and miR-143 in CAD patients showed significantly greater expression in PCAT from atherosclerotic lesion compared with plaque-free segments (1.32 /- 0.96 vs 0.82 /- 0.37 (P = .011), 0.91 /- 1.7 vs 0.3 /- 1.25 (P = .012), 1.2 /- 1.59 vs 0.43 /- 0.54 (P < .001), respectively). +other 36214765 hsa-mir-143 Heart Valve Diseases In addition, miR-133, miR-21, and miR-143 in CAD patients showed significantly greater expression in PCAT from atherosclerotic lesion compared with plaque-free segments (1.32 /- 0.96 vs 0.82 /- 0.37 (P = .011), 0.91 /- 1.7 vs 0.3 /- 1.25 (P = .012), 1.2 /- 1.59 vs 0.43 /- 0.54 (P < .001), respectively). +other 36214718 hsa-mir-20a Ischemic Stroke A rat middle cerebral artery occlusionreperfusion (MCAO/R) model was established to investigate the role of the HIF1alpha/miR20a5p/KIF5A axis in ischaemic stroke in vivo. +other 36214716 hsa-mir-92a Hirschsprung Disease Herein, elevated expression of miR92a and reduced expression of KLF4 were found in HSCR tissues, and their expression patterns were negatively correlated. +lncRNA target 36214714 hsa-mir-642a Glioblastoma This study was designed to explore the function of lncRNA MAFGAS1/miR642a5p/Notch1 in glioblastoma (GBM) cells under radiation. MAFGAS1 reduces the radiosensitivity of GBM cells via miR642a5p/Notch1 axis. +lncRNA target 36214709 hsa-mir-206 Alzheimer Disease The ADassociated network was constructed, including 2 lncRNAs (A2MAS1 and ZNF571AS1), 1 miRNA (hsamiR206), 2 mRNAs (NOTCH3 and JAG1), and 2 pathways (notch signaling pathway and endocrine resistance). A2MAS1, ZNF571AS1, hsamiR206, NOTCH3 and JAG1 may be involved in the mechanisms of AD through notch signaling pathway and endocrine resistance. +other 36214592 hsa-mir-223 Acute Coronary Syndrome 5p, miR-484, and miR-130a-3p in individuals with coronary artery disease (CAD). +other 36214592 hsa-mir-484 Acute Coronary Syndrome RESULTS: The miR-484 expression was significantly upregulated in the ACS subjects (P = .0097). CONCLUSION: The results of this study indicate that the upregulated expression of miR-484 in ACS patients might be used as a diagnostic biomarker in ACS. +other 36214592 hsa-mir-126 Acute Coronary Syndrome 5p, miR-484, and miR-130a-3p in individuals with coronary artery disease (CAD). +other 36214592 hsa-mir-130a Acute Coronary Syndrome 5p, miR-484, and miR-130a-3p in individuals with coronary artery disease (CAD). +circulation_biomarker_diagnosis_up 36213989 hsa-mir-942 Coronary Artery Disease RESULTS: Circ_HECW2 and TLR4 expression levels were up-regulated and miR5p expression was decreased in the serum of CAD patients and oxidized low-density lipoprotein (ox-LDL)-induced hCMECs. +circRNA target 36213989 hsa-mir-942 Cardiovascular Diseases CONCLUSION: Circ_HECW2 could regulate ox-LDL-induced cardiovascular endothelial cell dysfunction through targeting miR5p/TLR4 axis. +lncRNA target 36213586 hsa-mir-429 Nasopharyngeal Carcinoma CONCLUSIONS: High expression of MSC-AS1 exerted a carcinogenic effect on NPC cell growth and metastasis by inhibiting miR-429 and activating the JAK1/STAT3 pathway. +genetics_GWAS 36213264 hsa-mir-143 Diabetes Mellitus, Type 2 A functional polymorphism of microRNA-143 is associated with the risk of type 2 OBJECTIVE: To explore the association between two polymorphisms of microRNA-143 (miR-143) and the risk of type 2 diabetes mellitus (T2DM) in the northern Chinese Han population. +circulation_biomarker_diagnosis_up 36212996 hsa-mir-101 Diabetes Mellitus CONCLUSIONS: The peripheral blood miR-181c and miR-101 are low expressed in patients with DM complicated with AS, and advanced age, intracortical AS lesions, increased HbA1c, and low expression of miR-181c and miR-101 are all independent risk factors for CI in patients with DM complicated with AS. +circulation_biomarker_diagnosis_up 36212996 hsa-mir-181c Stroke CONCLUSIONS: The peripheral blood miR-181c and miR-101 are low expressed in patients with DM complicated with AS, and advanced age, intracortical AS lesions, increased HbA1c, and low expression of miR-181c and miR-101 are all independent risk factors for CI in patients with DM complicated with AS. +circulation_biomarker_diagnosis_up 36212996 hsa-mir-181c Diabetes Mellitus CONCLUSIONS: The peripheral blood miR-181c and miR-101 are low expressed in patients with DM complicated with AS, and advanced age, intracortical AS lesions, increased HbA1c, and low expression of miR-181c and miR-101 are all independent risk factors for CI in patients with DM complicated with AS. +circulation_biomarker_diagnosis_up 36212996 hsa-mir-101 Stroke CONCLUSIONS: The peripheral blood miR-181c and miR-101 are low expressed in patients with DM complicated with AS, and advanced age, intracortical AS lesions, increased HbA1c, and low expression of miR-181c and miR-101 are all independent risk factors for CI in patients with DM complicated with AS. +target gene 36212971 hsa-mir-28 Stomach Neoplasms miR-28-5p's Targeting of GAGE12I Inhibits Proliferation, Migration, and Invasion of Gastric Cancer in Vitro. +genetics_overexpression_promote 36212964 hsa-mir-641 Endometrial Neoplasms Overexpression of AP1G1 neutralized the roles of miR-641 mimic on the viability, proliferation, apoptosis, and migration of HEC-1A and HECCL-1 cells. +lncRNA target 36212960 hsa-let-7a Atrial Fibrillation We speculated that the interaction pairs of miR-125a-5p and let-7a-3p with target mRNAs and target lncRNAs may be involved in AF. +lncRNA target 36212960 hsa-mir-125a Atrial Fibrillation We speculated that the interaction pairs of miR-125a-5p and let-7a-3p with target mRNAs and target lncRNAs may be involved in AF. +target gene 36212408 hsa-mir-101 Breast Neoplasms LncRNA SNHG6 sponges miR-101 and induces tamoxifen resistance in breast cancer cells through induction of EMT. +other 36212369 hsa-mir-96 Dehydration As for the expression profile, 62 miRNAs were significantly differentially expressed under drought stress, being five up-regulated (miR396e, miR159b, miR529b, egu-miR19sds, and egu-miR29ds) and 57 down-regulated. +other 36212369 hsa-mir-159b Dehydration As for the expression profile, 62 miRNAs were significantly differentially expressed under drought stress, being five up-regulated (miR396e, miR159b, miR529b, egu-miR19sds, and egu-miR29ds) and 57 down-regulated. +other 36212369 hsa-mir-529b Dehydration As for the expression profile, 62 miRNAs were significantly differentially expressed under drought stress, being five up-regulated (miR396e, miR159b, miR529b, egu-miR19sds, and egu-miR29ds) and 57 down-regulated. +other 36212369 hsa-mir-19 Dehydration As for the expression profile, 62 miRNAs were significantly differentially expressed under drought stress, being five up-regulated (miR396e, miR159b, miR529b, egu-miR19sds, and egu-miR29ds) and 57 down-regulated. +other 36212136 hsa-mir-155 Endometriosis 5p-HIF1A, which may be closely related to OE development. +other 36212136 hsa-mir-34a Endometriosis 5p-HIF1A, which may be closely related to OE development. +other 36212136 hsa-mir-93 Endometriosis 5p-HIF1A, which may be closely related to OE development. +genetics_GWAS 36212130 hsa-mir-101 Carcinoma, Hepatocellular Our study is the first to demonstrate that besides genetic alteration and DNA methylation, AC145207.5/LINC01748-miR +transcription factor target 36211818 hsa-mir-28 Intervertebral Disc Degeneration 5p targets WWP2 to regulate nucleus pulposus cells apoptosis and then participates in the development of IDD. +other 36211602 hsa-mir-155 Asthma MicroRNA-155 (miR-155) has been implicated in IgE-dependent allergic disease including asthma and atopic dermatitis. +other 36211602 hsa-mir-155 Hypersensitivity, Immediate MicroRNA-155 (miR-155) has been implicated in IgE-dependent allergic disease including asthma and atopic dermatitis. +other 36211602 hsa-mir-155 Dermatitis, Atopic MicroRNA-155 (miR-155) has been implicated in IgE-dependent allergic disease including asthma and atopic dermatitis. +circulation_biomarker_diagnosis_up 36211468 hsa-mir-26a Carcinoma, Hepatocellular The results indicated that expression of the microRNA-26a, microRNA-29c, and microRNA-199a in both exosomes and plasma was significantly lower in HCC patients compared with hepatic cirrhosis and healthy group. Moreover, the exosomal microRNA panel containing microRNA-26a, microRNA-29c, and microRNA-199a showed high accuracy in discriminating HCC from healthy (AUC = 0.994; sensitivity 100%; specificity 96%) and hepatic cirrhosis group (AUC = 0.965; sensitivity 92%; specificity 90%). +circulation_biomarker_diagnosis_up 36211468 hsa-mir-199a Carcinoma, Hepatocellular The results indicated that expression of the microRNA-26a, microRNA-29c, and microRNA-199a in both exosomes and plasma was significantly lower in HCC patients compared with hepatic cirrhosis and healthy group. Moreover, the exosomal microRNA panel containing microRNA-26a, microRNA-29c, and microRNA-199a showed high accuracy in discriminating HCC from healthy (AUC = 0.994; sensitivity 100%; specificity 96%) and hepatic cirrhosis group (AUC = 0.965; sensitivity 92%; specificity 90%). +circulation_biomarker_diagnosis_up 36211468 hsa-mir-29c Carcinoma, Hepatocellular The results indicated that expression of the microRNA-26a, microRNA-29c, and microRNA-199a in both exosomes and plasma was significantly lower in HCC patients compared with hepatic cirrhosis and healthy group. Moreover, the exosomal microRNA panel containing microRNA-26a, microRNA-29c, and microRNA-199a showed high accuracy in discriminating HCC from healthy (AUC = 0.994; sensitivity 100%; specificity 96%) and hepatic cirrhosis group (AUC = 0.965; sensitivity 92%; specificity 90%). +lncRNA target 36211460 hsa-mir-19b Infertility, Male Conclusion: Findings suggest that the higher expression of miRNA-19a/b-3p or the lower expression of target genes are associated with oligoasthenozoospermia and male infertility, probably through influencing basic semen parameters. +lncRNA target 36211460 hsa-mir-19a Oligospermia Conclusion: Findings suggest that the higher expression of miRNA-19a/b-3p or the lower expression of target genes are associated with oligoasthenozoospermia and male infertility, probably through influencing basic semen parameters. +lncRNA target 36211460 hsa-mir-19b Oligospermia Conclusion: Findings suggest that the higher expression of miRNA-19a/b-3p or the lower expression of target genes are associated with oligoasthenozoospermia and male infertility, probably through influencing basic semen parameters. +lncRNA target 36211460 hsa-mir-19a Infertility, Male Conclusion: Findings suggest that the higher expression of miRNA-19a/b-3p or the lower expression of target genes are associated with oligoasthenozoospermia and male infertility, probably through influencing basic semen parameters. +circRNA target 36210730 hsa-mir-370 Tuberculosis 3p inhibition in TB progression. +lncRNA target 36210713 hsa-mir-125b Ovarian Neoplasms [MiR-125b-5 suppresses ovarian cancer cell migration and invasion by targeted OBJECTIVE: To investigate whether miR-125b-5p regulates biological behaviors of ovarian cancer cells by targeted regulation of CD147 expression. +genetics_knock down_suppress 36210706 hsa-let-7g Urinary Bladder Neoplasms Knocking down HMGB2 could partially reverse the effect of let-7g-3p knockdown on the biological behaviors of the bladder cancer cells. +transcription factor target 36210463 hsa-mir-124 Colorectal Neoplasms 5p through YAP1 nuclear translocation. +transcription factor target 36210463 hsa-mir-188 Colorectal Neoplasms 5p through YAP1 nuclear translocation. +transcription factor target 36210420 hsa-mir-210 Melanoma The results of our study showed that miR-210/ISCU/ROS axis can serve as a novel therapeutic target in melanoma. +transcription factor target 36209087 hsa-mir-133a Polycystic Ovary Syndrome CONCLUSION: MiR-133a-3p promotes ovary IR on GCs of obese PCOS patients via inhibiting PI3K/AKT signaling pathway. +transcription factor target 36209049 hsa-mir-92a-2 Diabetic Cardiomyopathies CONCLUSIONS: miR-92a5p plays an important role in cardiac oxidative stress, and may serve as a therapeutic target in DCM. +genetics_overexpression_promote 36209036 hsa-mir-539 Wilms Tumor Overexpression of HOXB2 partially restored the inhibitory effects of miR +other 36208811 hsa-mir-4638 Breast Neoplasms Overall, this study highlights the possibility of utilizing miR3p as a therapeutic molecule to curb skeletal metastasis of breast cancer cells. +other 36208715 hsa-mir-140 Osteoarthritis Finally, upregulation of miR-140 in 2D chondrocytes resulted in significant upregulation of WWP2 and WDR1. +lncRNA target 36208372 hsa-mir-433 Colorectal Neoplasms After analysis, it was found that circ_0001535 acted as a competing endogenous RNA (ceRNA) to inhibit miR +circulation_biomarker_prognosis_up 36208254 hsa-let-7b Multiple Myeloma CONCLUSION: Aberrant low expression levels of miR-21, miR-18a, and Let-7b derived from serum exosomes exist in patients with MM, which are associated with a worse overall survival rate. +circulation_biomarker_prognosis_ns 36208254 hsa-mir-146a Multiple Myeloma OBJECTIVE: To investigate the expression level and prognostic value of miR-21, miR-18a, miR-146a, and Let-7b derived from serum exosomes in patients with multiple myeloma (MM). +circulation_biomarker_prognosis_up 36208254 hsa-mir-21 Multiple Myeloma CONCLUSION: Aberrant low expression levels of miR-21, miR-18a, and Let-7b derived from serum exosomes exist in patients with MM, which are associated with a worse overall survival rate. +circulation_biomarker_prognosis_up 36208254 hsa-mir-18a Multiple Myeloma CONCLUSION: Aberrant low expression levels of miR-21, miR-18a, and Let-7b derived from serum exosomes exist in patients with MM, which are associated with a worse overall survival rate. +genetics_knock down_promote 36208253 hsa-mir-21 Multiple Myeloma KLF5 plasmid with 3'UTR knockout was synthesized and cotransfected into RPMI-8226 cells with hsa-miR-21 mimics, and the proliferation of MM cells was detected by CCK-8 and cell cloning assay. +genetics_overexpression_suppress 36208244 hsa-mir-532 Lymphoma, Large B-Cell, Diffuse CONCLUSION: Overexpression of miR +lncRNA target 36208243 hsa-mir-126 Lymphoma, Large B-Cell, Diffuse The DLBCL cell line SU-DHL-4 was transfected with miR-126 inhibitor and its negative control (NC inhibitor) or miR-126 mimics and its negative control (NC mimics). +genetics_overexpression_promote 36208229 hsa-mir-196b Leukemia, Myeloid, Acute CONCLUSION: Overexpression of lncRNA XIST can inhibit the proliferation of acute myeloid leukemia cells KG1a and promote apoptosis by down-regulating the expression of miR-196b. +circulation_biomarker_diagnosis_ns 36207607 hsa-mir-20b Lymph Node Metastasis CONCLUSIONS: This study suggests that serum miR-20b-5p is a potential biomarker for predicting LNM and can be helpful for precise clinical decision-making strategies and improve treatment outcomes for T1 ESCC patients. +circulation_biomarker_diagnosis_ns 36207607 hsa-mir-20b Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: This study suggests that serum miR-20b-5p is a potential biomarker for predicting LNM and can be helpful for precise clinical decision-making strategies and improve treatment outcomes for T1 ESCC patients. +lncRNA target 36207305 hsa-mir-499a Bipolar Disorder Our results suggest that MIR499A dysregulation might contribute to BD development. +lncRNA target 36206975 hsa-mir-150 Bone Diseases 5p inhibition and hydroxyapatite/tricalcium phosphate ceramic powders enhanced bone regeneration. +exosome 36206599 hsa-mir-145 Reperfusion Injury, Cerebral Ischemia CONCLUSION: Collectively, exosomal miRderived from MSCs was able to attenuate cerebral I/R injury through downregulation of FOXO1. +circulation_biomarker_diagnosis_up 36206272 hsa-mir-19b Polycystic Ovary Syndrome According to our data, circulating miR +circulation_biomarker_diagnosis_up 36206272 hsa-mir-21 Polycystic Ovary Syndrome According to our data, circulating miR +circulation_biomarker_diagnosis_up 36206272 hsa-mir-222 Polycystic Ovary Syndrome According to our data, circulating miR +circulation_biomarker_diagnosis_up 36206272 hsa-mir-103a Polycystic Ovary Syndrome According to our data, circulating miR +circulation_biomarker_diagnosis_up 36206272 hsa-mir-376a Polycystic Ovary Syndrome According to our data, circulating miR +circulation_biomarker_diagnosis_up 36206272 hsa-mir-26a Polycystic Ovary Syndrome According to our data, circulating miR +circulation_biomarker_diagnosis_up 36206272 hsa-mir-23a Polycystic Ovary Syndrome According to our data, circulating miR +circulation_biomarker_prognosis_ns 36206229 hsa-mir-125b Inflammatory Bowel Diseases CONCLUSION: Serum LncRNA THRIL and MiR-125b could be used as potential biomarkers for diagnosis and prognosis of ulcerative colitis and Crohn's disease. +genetics_knock down_suppress 36206143 hsa-mir-377 Chordoma 3p overexpression-mediated antitumor effects in chordoma cells were largely attenuated by SMAD3 overexpression. +genetics_overexpression_promote 36206112 hsa-mir-497 Esophageal Squamous Cell Carcinoma 5p overexpression-mediated influences in ESCC cells were largely reversed by the addition of SLC1A5 expressing plasmid. +exosome 36206102 hsa-mir-449a Stomach Neoplasms Exosomal circ_0063526 facilitated CDDP resistance in gastric cancer via regulating the miR-449a/SHMT2 axis. +other 36206098 hsa-mir-197 Pituitary Neoplasms Our findings suggest a regulatory network of lncRNA MYMLR/miR3p/CBR1, which benefits the understanding of PA development and provides a promising lncRNA-direct therapeutic strategy against PA. +genetics_overexpression_suppress 36206095 hsa-mir-512 Carcinoma, Non-Small-Cell Lung 5p could be sponged by circ_0010235, and its overexpression had an inhibition effect on the PTX resistance of NSCLC cells. +genetics_knock down_suppress 36204881 hsa-mir-197 Gastrointestinal Stromal Tumors 3p reversed the effect of circ-CCS knockdown on apoptosis and autophagy in GIST cells. +other 36204642 hsa-mir-23b Carcinoma, Hepatocellular Based on their RNA-RNA interaction and expression analysis, four DElncRNAs (TRHDE-AS1, DLX6-AS1, SNHG14, HOXA11-AS), four DEmiRNAs (miR-23b, miR-320a, miR-589, miR-126) and five DEmRNAs (PKIA, PCDHA2, SHCBP1, PRSS16, KIF18A) in HCC tumor vs normal groups were subjected to the hub regulatory networks analysis and further prognostic value analysis. Importantly, the TRHDE-AS1/miR-23b/PKIA ceRNA network was associated with HCC prognosis. +other 36204577 hsa-mir-222 Cardiomyopathies CONCLUSION: In summary, we propose that THBS1 may be a key IRHG, and can serve as a biomarker for the diagnosis of SCM; in addition, the immune-related regulatory network miR3p/THBS1 may be involved in the regulation of the pathogenesis of SCM and may serve as a promising candidate for SCM therapy. +other 36204312 hsa-mir-21 Tuberculosis A ceRNA network mediated by the MIR600HG/hsa-mir5p axis was constructed, in which the significant gene cluster regulated the critical T subsets in TB activation. +other 36204312 hsa-mir-600 Tuberculosis A ceRNA network mediated by the MIR600HG/hsa-mir5p axis was constructed, in which the significant gene cluster regulated the critical T subsets in TB activation. +target gene 36204179 hsa-mir-522 Stomach Neoplasms MiR-522-3p Targets Transcription Factor 4 to Overcome Cisplatin Resistance of Gastric Cells. +lncRNA target 36204112 hsa-mir-129-1 Neurotoxicity Syndromes Collectively, we found a novel circ_0015891/miR1-3p axis that may be a promising therapeutic target for METH-induced dopaminergic neurotoxicity. +other 36203804 hsa-mir-145 Dementia, Vascular 5p), six TFs (Csrnp1, Klf4, Nfatc4, Rxrg, Foxj2, and Klf5), and five mRNAs (Serpine1, Plec, Nedd4l, Trip12, and Tpm1) were significantly changed in rats with VaD, in line with the outcome of RNA sequencing. +circRNA target 36203795 hsa-mir-7001 Postoperative Cognitive Complications 5p/Sostdc1 may be novel diagnostic biomarkers and therapeutic targets for POCD. +circRNA target 36203795 hsa-mir-490 Postoperative Cognitive Complications 5p/Sostdc1 may be novel diagnostic biomarkers and therapeutic targets for POCD. +lncRNA target 36203618 hsa-mir-150 Osteoarthritis 5p were lower in human OA synovial tissue compared with non-OA specimens. +other 36203524 hsa-mir-421 Nasopharyngeal Carcinoma 5p are differentially regulated after chemoradiotherapy in NPC. +other 36203524 hsa-mir-339 Nasopharyngeal Carcinoma 5p are differentially regulated after chemoradiotherapy in NPC. +other 36203524 hsa-mir-18a Nasopharyngeal Carcinoma 5p are differentially regulated after chemoradiotherapy in NPC. +other 36203524 hsa-mir-483 Nasopharyngeal Carcinoma 5p are differentially regulated after chemoradiotherapy in NPC. +other 36203524 hsa-mir-133a Nasopharyngeal Carcinoma 5p are differentially regulated after chemoradiotherapy in NPC. +other 36203524 hsa-mir-584 Nasopharyngeal Carcinoma 5p are differentially regulated after chemoradiotherapy in NPC. +other 36203524 hsa-mir-122 Nasopharyngeal Carcinoma 5p are differentially regulated after chemoradiotherapy in NPC. +other 36203524 hsa-mir-106b Nasopharyngeal Carcinoma 5p are differentially regulated after chemoradiotherapy in NPC. +genetics_knock down_suppress 36203485 hsa-mir-34c Stomach Neoplasms This study aimed to investigate the expression, biological function, and downstream mechanism of miR-34c-5p in GC, provide new targets for gastric cancer diagnosis and treatment. miR-34c-5p overexpression inhibited migration, invasion, and colony formation of gastric cancer cells, the related protein E-cadherin expression was significantly increased and N-cadherin, vimentin, and PCNA expression were significantly decreased, while miR-34c-5p knockdown exerted the opposite effects. +lncRNA target 36203462 hsa-mir-182 Carcinoma, Hepatocellular Notably, while the expression of most miRs deregulated in preneoplastic lesions was not altered in HCC or in hepatoma cells, miR-182, a miR known to target Dio1 and mitochondrial complexes, was down-deregulated by T3 treatment at all stages of hepatocarcinogenesis and in hepatocarcinoma cell lines. In support to the possible critical role of miR-182 in hepatocarcinogenesis, exogenous expression of this miR significantly impaired the inhibitory effect of T3 on the clonogenic growth capacity of human HCC cells. +exosome 36203260 hsa-mir-375 Hepatitis C miR-375, secreted through exosomes derived from HCV-infected cells, could also be transferred to naive Huh7.5 cells, resulting in an increase in cell proliferation and migration in the recipient cells. +lncRNA target 36202872 hsa-mir-186 Triple Negative Breast Neoplasms 5p regulated the cell viability rate of docetaxel-resistant breast cancer cells. +lncRNA target 36202651 hsa-mir-335 Adrenal Cortex Neoplasms CONCLUSION: A messenger RNA-microRNA-long noncoding RNA network analysis identified the BIRC5-miR335-5p-PAX8-AS1 network as one that was associated with poor overall survival in adrenocortical carcinoma, warranting further validation as a potential therapeutic target. +other 36202613 hsa-mir-16 Distal myopathy, Nonaka type To the best of our knowledge, this is the first time that a predictive signature has been composed of genes belonging to the same mechanism (miR-16) in UM. Altogether, our results strongly suggest that UM is a miR-16 disease. +other 36202232 hsa-mir-363 Melanoma 3p (>2.5-fold increase, P < 0.014). +other 36202232 hsa-mir-1 Melanoma 3p (>2.5-fold increase, P < 0.014). +other 36202232 hsa-mir-206 Melanoma 3p (>2.5-fold increase, P < 0.014). +other 36202232 hsa-mir-4286 Melanoma 3p (>2.5-fold increase, P < 0.014). +other 36202232 hsa-mir-146a Melanoma 3p (>2.5-fold increase, P < 0.014). +other 36202232 hsa-mir-196b Melanoma 3p (>2.5-fold increase, P < 0.014). +genetics_knock down_suppress 36202224 hsa-mir-424 von Willebrand Diseases Additionally, knockdown of transcription factor YY1 and transfection of hsa-miR-424 mimics had a synergistic effect in reducing hypoxia-induced VWF production of breast cancer cells, cell migration and angiogenesis in vitro. +genetics_knock down_suppress 36202224 hsa-mir-424 Breast Neoplasms Additionally, knockdown of transcription factor YY1 and transfection of hsa-miR-424 mimics had a synergistic effect in reducing hypoxia-induced VWF production of breast cancer cells, cell migration and angiogenesis in vitro. +transcription factor target 36202203 hsa-mir-17 Necrobiotic Disorders 5p inhibitor cell model, resulting in the inactivation of NLRP3 inflammasome-dependent pyroptosis. +circulation_biomarker_diagnosis_up 36201274 hsa-mir-26b Cardiomegaly Thereafter, the CHF rats were injected with relative oligonucleotides and plasmids of HDAC3, miR-26b-3p and HMGA2 to detect the cardiac function, inflammatory reaction, myocardial tissue pathological changes, and cardiomyocyte apoptosis. +transcription factor target 36200697 hsa-mir-527 Acute Kidney Injury CONCLUSION: Downregulation of miR-527 alleviated sepsis-induced AKI via targeting Beclin1. +transcription factor target 36200697 hsa-mir-527 Sepsis CONCLUSION: Downregulation of miR-527 alleviated sepsis-induced AKI via targeting Beclin1. +genetics_knock down_promote 36200682 hsa-mir-421 Pancreatic Carcinoma HIF-1alpha overexpression reversed the inhibiting effects of SIRT3 overexpression on PC progression and counteracted the inhibiting effects of miR-421 knockdown on glycolysis. +other 36200549 hsa-mir-223 Diabetes Mellitus After inclusion of covariates, age, gender (male), New York Heart Association class and diabetes into the multivariate Cox regression model, miR-223 did not reach statistical significance (HR: 2.56, 95% CI: 0.79-8.33; p = 0.118). +genetics_knock down_suppress 36200529 hsa-mir-20b Colorectal Neoplasms Reducing miR-20b-3p or raising DEPDC1 levels weakened the effect of SIRT1 knockdown on L-OHP-resistant-CRC cells. +other 36200149 hsa-mir-3074 Diabetic Ischemia Complication One miRNA that was highly significantly upregulated in diabetic rabbit but not in ischemic rabbits was miRNA5p. +other 36200149 hsa-mir-3074 Diabetes Mellitus One miRNA that was highly significantly upregulated in diabetic rabbit but not in ischemic rabbits was miRNA5p. +genetics_overexpression_promote 36200131 hsa-mir-194 Hypertensive Retinopathy 5p upregulation restrained angiogenesis and increased tight junction protein levels in Ang II-treated HRMECs, and the effect was reversed by SOX17 overexpression. +other 36200027 hsa-mir-139 Adrenocortical Carcinoma, Pediatric We proposed that the hub genes (MAPK1, EP300, hsa-miR-376, hsa-miR-148, hsa-miR-139, and hsa-miR-1305) may have a definite impact on cellular proliferation and migration in adrenocortical tumors. +other 36200027 hsa-mir-148 Adrenocortical Carcinoma, Pediatric We proposed that the hub genes (MAPK1, EP300, hsa-miR-376, hsa-miR-148, hsa-miR-139, and hsa-miR-1305) may have a definite impact on cellular proliferation and migration in adrenocortical tumors. +other 36200027 hsa-mir-1305 Adrenocortical Carcinoma, Pediatric We proposed that the hub genes (MAPK1, EP300, hsa-miR-376, hsa-miR-148, hsa-miR-139, and hsa-miR-1305) may have a definite impact on cellular proliferation and migration in adrenocortical tumors. +other 36200027 hsa-mir-376 Adrenocortical Carcinoma, Pediatric We proposed that the hub genes (MAPK1, EP300, hsa-miR-376, hsa-miR-148, hsa-miR-139, and hsa-miR-1305) may have a definite impact on cellular proliferation and migration in adrenocortical tumors. +circulation_biomarker_diagnosis_ns 36200021 hsa-mir-29 Hypertension OBJECTIVE: This study aims to analyze the expressions of miR-21, miR-29, and miR-199 in the serum of the patients with H-type hypertension among Kazakhs. CONCLUSION: miR-21, miR-29, and miR-199 are associated with H-type hypertension in the Kazakhs, especially hyperhomocysteinemia. +genetics_GWAS 36200021 hsa-mir-21 Hypertension METHOD: In this study, the expression of miR-21, miR-29, and miR-199 was quantitatively measured in 120 serum samples and then stratified according to the C677T polymorphism to analyze the relationship between target miRNAs and HHcy. In the CC and CT genotypes of MTHFR 677C > T, the expression of miR-21 was lower in the HHcy patients than in the normal individuals (P = 0.005 and P = 0.001) and miR-199 was significantly higher in the HHcy patients than in the normal ones (P = 0.002 and P = 0.048). +circulation_biomarker_diagnosis_ns 36200021 hsa-mir-199 Hypertension OBJECTIVE: This study aims to analyze the expressions of miR-21, miR-29, and miR-199 in the serum of the patients with H-type hypertension among Kazakhs. CONCLUSION: miR-21, miR-29, and miR-199 are associated with H-type hypertension in the Kazakhs, especially hyperhomocysteinemia. +lncRNA target 36199788 hsa-mir-31 Osteosarcoma 3p affected the occurrence and development of osteosarcoma by targeting the SOCS1/JAK2/STAT3 signaling pathway. +exosome 36199785 hsa-mir-1246 Squamous Cell Carcinoma of Head and Neck Macrophages transfected with miR-1246 inhibitor suppressed LSCC cell viability, migration, and invasion. CONCLUSION: In summary, our data implied that the exosomal, miR-1246 of LSCC, induced polarization of M2 type macrophages and promoted the progression of LSCC. +lncRNA target 36199571 hsa-mir-154 Urinary Bladder Neoplasms Second, significantly altered miRNAs in recurrent bladder cancer were identified, with miR5p showing the highest level of editing in recurrent bladder cancer and may up-regulate the expression levels of downstream targets HS3ST3A1, AQP9, MYLK, and RAB23. +target gene 36199554 hsa-mir-7 Colorectal Neoplasms The Transcription Factor Otc4A Stimulates the Proliferation, Invasion, and Stemness of Colorectal Cancer Cells by Inhibiting the Regulation of miR-7-5p on TLR4. +other 36199284 hsa-mir-21 Esophageal Neoplasms However, the results are varied, and no studies on the diagnostic usefulness of miR-21 in Asian esophageal cancer (EC) patients have been published. CONCLUSION: Our findings suggest miR-21 might be the potential biomarker for detecting EC in Asian populations, with a good diagnostic value. +lncRNA target 36199080 hsa-mir-10a Osteosarcoma CONCLUSION: Lnc-SELPLG-2:1 is an oncogenesis activator in osteosarcoma, and its functions are performed via hsa-miR-10a-5p /BTRC cascade. +genetics_knock down_promote 36198257 hsa-mir-133b Pneumonia, Mycoplasma CONCLUSION: The current evidence demonstrated that circ_0088196 knockdown facilitated trophoblastic cell development by regulating the levels of miR-133b and AHNAK, suggesting that circ_0088196 promoted the PE progression via the miR-133b/AHNAK axis. +genetics_overexpression_promote 36198203 hsa-mir-20b Uterine Cervical Neoplasms The impacts of MEF2C-AS1 elevation on CC cell proliferative, migratory, and angiogenic capabilities were countervailed by miR-20 b-5p overexpression. +circulation_biomarker_diagnosis_ns 36198129 hsa-mir-499 Myocardial Infarction It enables the rapid detection of an AMI-related miRNA (miR-499) at 10 aM in human serum within 30 min using the SNAzyme-catalyzed luminol-H(2)O(2) ECL reaction. This sensing strategy is then utilized for AMI diagnosis via probing endogenous miR-499 in patients' circulating blood with endogenous miR-16 as an intrinsic reference, showing a significant difference (P < 0.001) between the miR-499 levels of patients and the healthy. +lncRNA target 36197604 hsa-mir-21 Coronary Artery Disease CONCLUSIONS: Results from the present study suggest that SGPP1, ATG5 and LRP6, target genes of miR-133b and miR-21, may serve as potential therapeutic hotspots in the management of coronary artery disease, which undoubtedly merit further experimental confirmation. +lncRNA target 36197604 hsa-mir-133b Coronary Artery Disease CONCLUSIONS: Results from the present study suggest that SGPP1, ATG5 and LRP6, target genes of miR-133b and miR-21, may serve as potential therapeutic hotspots in the management of coronary artery disease, which undoubtedly merit further experimental confirmation. +genetics_overexpression_promote 36197580 hsa-mir-377 Glioma 3p downregulation or LMX1A overexpression reversed the inhibition of silencing lncRNA MIR210HG on glioma cell proliferation. +circulation_biomarker_prognosis_down 36197268 hsa-mir-34a Osteosarcoma CONCLUSION: The expression level of serum miR-34a in patients with OS is closely related to the chemotherapy resistance, metastasis, recurrence, and survival of osteosarcoma, which can be used as one of the potential biomarkers and prognosis for the treatment of OS patients. +circulation_biomarker_diagnosis_ns 36197244 hsa-mir-21 Cardiomegaly These findings indicate the potential crosstalk between serum miR-21 and inflammation during CHF progression, suggesting the potential of miR-21 in CHF diagnosis, severity indication, and treatment. +genetics_overexpression_suppress 36196919 hsa-mir-760 Carcinoma, Non-Small-Cell Lung Furthermore, KIF2A overexpression neutralized miR +other 36196089 hsa-mir-22 Myopathies, Structural, Congenital Our results identify RYR1, ATPB2B and miRNA-22 as common transcripts whose expression is decreased in muscles from congenital myopathy patients. +lncRNA target 36195937 hsa-mir-148a Cardiomegaly Similar results were obtained in angiotensin II-induced hypertrophy of NRCMs, in which the beneficial effects of HHP-EXO were abolished by miRNA-148a inhibition. +genetics_overexpression_promote 36195847 hsa-mir-200a Papillomavirus Infections RESULTS: The results demonstrated that miR-200a-3p overexpression suppressed proliferation, migration, and invasion of the HPV-negative C33A cells but promoted the growth and metastasis of HPV-positive CC cells, while YAP promoted the cell growth and metastasis not only in HPV-negative but also in the HPV-positive CC cells. +lncRNA target 36195691 hsa-mir-1192 Reperfusion Injury, Cerebral Ischemia Overall, GAS5 silencing inhibited AQP4 through the miR-1192/STAT5A axis, thus alleviating cerebral I/R injury. +circulation_biomarker_diagnosis_ns 36195304 hsa-mir-492 Pneumonia, Mycoplasma OBJECTIVE: This study aimed to evaluate the role of miRNA-492 in the progression of mycoplasma pneumoniae (MP) infection in pediatric patients. CONCLUSION: The present study's results suggested that miRNA-492 might play a role in the pathogenesis of mycoplasma pneumoniae pneumonia in children by regulating the secretion of immune-inflammatory factors such as IL-6 and IL-18 in the mononuclear macrophages. +transcription factor target 36195241 hsa-mir-181b Liver Cirrhosis Our findings suggest that miR-181b might be a potentially novel therapeutic target for schistosomiasis-induced liver fibrosis. +transcription factor target 36195241 hsa-mir-181b Schistosomiasis Our findings suggest that miR-181b might be a potentially novel therapeutic target for schistosomiasis-induced liver fibrosis. +other 36194985 hsa-mir-619 Osteoarthritis CONCLUSION: Circ_0022383 protected chondrocytes from IL-1beta-induced apoptosis, inflammation and ECM degeneration by miR5p/SIRT1 axis, inspiring future therapy development for OA prevention. +other 36194985 hsa-mir-619 Osteoarthritis  CONCLUSION: Circ_0022383 protected chondrocytes from IL-1beta-induced apoptosis, inflammation and ECM degeneration by miR5p/SIRT1 axis, inspiring future therapy development for OA prevention. +other 36194985 hsa-mir-619 Inflammation CONCLUSION: Circ_0022383 protected chondrocytes from IL-1beta-induced apoptosis, inflammation and ECM degeneration by miR5p/SIRT1 axis, inspiring future therapy development for OA prevention. +lncRNA target 36194972 hsa-mir-221 Arthritis, Rheumatoid The therapeutic effect of triptolide on miR-221 Exs was reversed by miR-221 inhibitor in both normal and RA FLS. +genetics_GWAS 36194668 hsa-mir-181a Retinal Diseases Here, we show that miR-181a/b silencing has a beneficial effect also in IRDs. Overall, these data support the potential use of miR-181a/b downregulation as an innovative mutation-independent therapeutic strategy for IRDs, which can be effective both to delay disease progression and to aid gene-specific therapeutic approaches. +genetics_GWAS 36194668 hsa-mir-181b Retinal Diseases Here, we show that miR-181a/b silencing has a beneficial effect also in IRDs. Overall, these data support the potential use of miR-181a/b downregulation as an innovative mutation-independent therapeutic strategy for IRDs, which can be effective both to delay disease progression and to aid gene-specific therapeutic approaches. +genetics_GWAS 36194484 hsa-mir-1307 Anxiety Disorders OBJECTIVE: Our present study intended to examine the associations of RPEL1 and miR-1307 gene polymorphisms (rs4917385 and rs7911488) with susceptibility, glucocorticoids (GCs) efficacy, anxiety, depression, and health-related quality of life (HRQoL) in Chinese systemic lupus erythematosus (SLE) patients. CONCLUSION: RPEL1 and miR-1307 gene polymorphisms (rs4917385 and rs7911488) might be related to SLE susceptibility in Chinese population. +genetics_GWAS 36194484 hsa-mir-1307 Depression OBJECTIVE: Our present study intended to examine the associations of RPEL1 and miR-1307 gene polymorphisms (rs4917385 and rs7911488) with susceptibility, glucocorticoids (GCs) efficacy, anxiety, depression, and health-related quality of life (HRQoL) in Chinese systemic lupus erythematosus (SLE) patients. CONCLUSION: RPEL1 and miR-1307 gene polymorphisms (rs4917385 and rs7911488) might be related to SLE susceptibility in Chinese population. +target gene 36193940 hsa-mir-214 Carcinoma, Non-Small-Cell Lung CircTADA2A up-regulates MAPK8 by targeting MiR-214-3p and recruiting EIF4A3 to promote the invasion and migration of non-small cell lung cancer cells. +genetics_knock down_promote 36193788 hsa-mir-1253 Lung Neoplasms Circ-EIF3I could sponge miR-1253, and miR-1253 inhibitor overturned the regulation of circ-EIF3I knockdown on LC cell progression. +genetics_overexpression_promote 36193608 hsa-mir-9a Ceroid lipofuscinosis, neuronal 5 In the VILI rat model, miR-9a-5p targeted the negative regulation of CXCR4, and CXCR4 overexpression to reverse the lung-protective and anti-inflammatory effects of miR-9a-5p overexpression in VILI rats. +transcription factor target 36193608 hsa-mir-9a Lung Injury CONCLUSION: miR-9a-5p can hinder the activation of the MAPK/ERK signaling pathway and reduce inflammatory reactions and lung injury in VILI rats through the targeted regulation of CXCR4 expression. +lncRNA target 36193590 hsa-let-7e Hematologic Diseases Let-7e-5p may be a potential therapeutic target of benzene-induced hematotoxicity, provide a basis for evaluating the health hazards of long-term and low-dose benzene exposure in workers, and supply a reference for revising occupational health standards. +lncRNA target 36193508 hsa-mir-182 Carcinoma, Non-Small-Cell Lung CONCLUSION: We demonstrated that hsa_circ_0003176 suppressed the NSCLC progression via regulating miR +other 36193506 hsa-mir-28 Pain 5p in PA cells. +other 36193503 hsa-mir-125b Hepatitis B, Chronic 5p, miR-181a-5p, and miR-29b-3p, were identified as the potential biomarkers in CHB, and the PPI and miRNA-mRNA networks were also established. +other 36193503 hsa-mir-181a Hepatitis B, Chronic 5p, miR-181a-5p, and miR-29b-3p, were identified as the potential biomarkers in CHB, and the PPI and miRNA-mRNA networks were also established. +other 36193503 hsa-mir-139 Hepatitis B, Chronic 5p, miR-181a-5p, and miR-29b-3p, were identified as the potential biomarkers in CHB, and the PPI and miRNA-mRNA networks were also established. +other 36193503 hsa-mir-29b Hepatitis B, Chronic 5p, miR-181a-5p, and miR-29b-3p, were identified as the potential biomarkers in CHB, and the PPI and miRNA-mRNA networks were also established. +other 36193503 hsa-mir-140 Hepatitis B, Chronic 5p, miR-181a-5p, and miR-29b-3p, were identified as the potential biomarkers in CHB, and the PPI and miRNA-mRNA networks were also established. +other 36193503 hsa-mir-122 Hepatitis B, Chronic 5p, miR-181a-5p, and miR-29b-3p, were identified as the potential biomarkers in CHB, and the PPI and miRNA-mRNA networks were also established. +genetics_GWAS 36193501 hsa-mir-137 Bipolar Disorder This preliminary study is aimed at investigating the effects of genetic variations in miR-137 (rs1625579A/C), TCF4 (rs1261084C/T), and CACNA1C (rs10774053A/G and rs10466907G/T) on BD susceptibility. +lncRNA target 36193326 hsa-mir-20a Femur Head Necrosis Moreover, we proposed a ceRNA network of lncRNAs targeting hsa-miR-320a, hsa-miR-320a, and NOD2 as a potential RNA regulatory pathway that controls disease progression in ONFH. +transcription factor target 36193307 hsa-mir-20a Colorectal Neoplasms 5p miR-20a-3p, and miR-636 targeted the PCK1 biomarker in the PPAR signaling pathway, which is involved in oxaliplatin-resistant CRC. +transcription factor target 36193307 hsa-mir-636 Colorectal Neoplasms 5p miR-20a-3p, and miR-636 targeted the PCK1 biomarker in the PPAR signaling pathway, which is involved in oxaliplatin-resistant CRC. +transcription factor target 36193307 hsa-mir-7 Colorectal Neoplasms 5p miR-20a-3p, and miR-636 targeted the PCK1 biomarker in the PPAR signaling pathway, which is involved in oxaliplatin-resistant CRC. +other 36193251 hsa-mir-100 Melanoma 5p is revealed, and the present study is followed by a discussion of its molecular regulatory network, followed by novel insights into SKCM therapy. +circulation_biomarker_diagnosis_ns 36193149 hsa-mir-184 Respiratory Distress Syndrome OBJECTIVE: To investigate the efficacy of high-volume hemofiltration (HVHF) in the treatment of severe acute respiratory distress syndrome (ARDS) caused by sepsis and its effect on serum levels of miR-126, miR-184, and MAP1-LC3. +circulation_biomarker_diagnosis_ns 36193149 hsa-mir-126 Respiratory Distress Syndrome OBJECTIVE: To investigate the efficacy of high-volume hemofiltration (HVHF) in the treatment of severe acute respiratory distress syndrome (ARDS) caused by sepsis and its effect on serum levels of miR-126, miR-184, and MAP1-LC3. +genetics_knock down_suppress 36193129 hsa-mir-654 Colonic Neoplasms CONCLUSION: Collectively, this study revealed that the knockdown of LINC01124 inhibited the malignant behaviors of CC via the miR +other 36193069 hsa-mir-192 Glioma 5p/ZEB2 axis. +genetics_knock down_promote 36192755 hsa-mir-1827 Carcinoma, Non-Small-Cell Lung Also, SLC1A5 overexpression abolished the inhibition effect of miR-1827 on NSCLC cell progression. +circulation_biomarker_diagnosis_ns 36192429 hsa-mir-126 Carotid Artery Diseases Lowly expressed miR-223 and miR-126 in the serum of CA patients can be used as indicators for plaque stability. +circulation_biomarker_diagnosis_ns 36192429 hsa-mir-223 Carotid Artery Diseases Lowly expressed miR-223 and miR-126 in the serum of CA patients can be used as indicators for plaque stability. +genetics_knock down_promote 36192016 hsa-mir-1303 Carcinoma, Hepatocellular Knockdown of miR-1303 attenuated cell proliferation, migration and invasion, and induced apoptosis in liver-cancer cells. +lncRNA target 36192016 hsa-mir-1303 Liver Neoplasms However, the biological role of miR-1303 in the progression of liver cancer and its regulatory mechanism has not been elucidated. CONCLUSION: miR-1303 plays an important role in liver cancer, which is inhibited by TLN1 expression. +other 36191794 hsa-mir-328a Pregnancy, Prolonged Quantitative real-time reverse transcription-polymerase chain reaction was performed to assess miR-328a-3p levels 0, 1, 4, 7 and 14 days post-sciatic nerve damage. +other 36191794 hsa-mir-328a Sciatic Neuropathy Quantitative real-time reverse transcription-polymerase chain reaction was performed to assess miR-328a-3p levels 0, 1, 4, 7 and 14 days post-sciatic nerve damage. +circRNA target 36191606 hsa-mir-765 Fluoride Poisoning We further showed that hsa_circ_0007478/miR-765/EFNA3 axis could also be involved in the inhibition of the lipid metabolism and foam cells formation in ox-LDL-macrophages. +lncRNA target 36191448 hsa-mir-125b Ovarian Neoplasms CONCLUSION: KCNQ1OT1 accelerated OC progression via miR-125b-5p/CD147 axis indicating KCNQ1OT1 serve as a novel biomarker for OC treatment. +lncRNA target 36191447 hsa-mir-648 Stomach Neoplasms METHODS: The current study sought to evaluate the miR-648 expression in GC and any plausibility of its replacement, either with or without the combination of chemo agents to downregulate ET-1 expression through interaction with its target gene. +circulation_biomarker_diagnosis_ns 36191258 hsa-mir-210 Sleep Apnea, Obstructive ECs transfected with miR-210 or treated with OSA serum showed reduced [Formula: see text]o(2) rate, mitochondrial membrane potential, and DNA abundance. +circulation_biomarker_diagnosis_ns 36191258 hsa-mir-210 Acute Lung Injury ECs transfected with miR-210 or treated with OSA serum showed reduced [Formula: see text]o(2) rate, mitochondrial membrane potential, and DNA abundance. +genetics_overexpression_promote 36190650 hsa-mir-206 Esophageal Neoplasms Meanwhile, overexpression of HOXA13 partially reversed the suppressive effects of miR-206 enrichment on ESCC cell malignant behaviors. CONCLUSION: In short, circ_0008726 exerted the carcinogenic effects to regulate the proliferation, invasion, angiogenesis and apoptosis of ESCC cells by targeting miR-206/HOXA13 axis. +lncRNA target 36190453 hsa-mir-375 Stomach Neoplasms This study provides a potential target for gastric cancer progression based on the circRPPH1/miR-375/SLC7A11 regulatory axis. +circRNA target 36190397 hsa-mir-1234 Stomach Neoplasms Furthermore, OE of hsa_circ_0006470 inhibited the tumorigenesis of GC via the regulation of the miR-1234/TP53I11 axis. In summary, the present study demonstrated that OE of hsa_circ_0006470 notably inhibited the tumorigenesis of GC by regulating the miR-1234/TP53I11 axis. +exosome 36190183 hsa-mir-221 Cerebrovascular Disorders In conclusion, miR3p in EPC derived exosomes ameliorates OGD-induced neuronal apoptosis, which establish its potential as a new therapeutic method for patients with cerebrovascular diseases. +other 36189421 hsa-mir-143 Colorectal Neoplasms Chemically modified MIR143-3p exhibited anti-cancer effects by impairing the KRAS network in colorectal cancer cells. +lncRNA target 36189147 hsa-mir-133c Myocardial Reperfusion Injury CONCLUSION: In sum, the identified ceRNA network which included the lncRNA Xist/miR-133c/Slc30a9 axis might contribute a better understanding to the pathogenesis and development of MI/R injury and offer a novel targeted therapy way. +circulation_biomarker_diagnosis_ns 36188428 hsa-mir-181a Rh-Negative Hemolytic Disease, Fetus 3p were highly expressed in maternal plasma of newborns with Rh-HDFN compared with healthy controls, indicating the potential roles of these two miRNAs in Rh-HDFN. +circulation_biomarker_diagnosis_ns 36188428 hsa-mir-125b-2 Rh-Negative Hemolytic Disease, Fetus 3p were highly expressed in maternal plasma of newborns with Rh-HDFN compared with healthy controls, indicating the potential roles of these two miRNAs in Rh-HDFN. +circulation_biomarker_diagnosis_ns 36188428 hsa-mir-181a Placenta Diseases 3p were highly expressed in maternal plasma of newborns with Rh-HDFN compared with healthy controls, indicating the potential roles of these two miRNAs in Rh-HDFN. +circulation_biomarker_diagnosis_ns 36188428 hsa-mir-125b-2 Placenta Diseases 3p were highly expressed in maternal plasma of newborns with Rh-HDFN compared with healthy controls, indicating the potential roles of these two miRNAs in Rh-HDFN. +other 36188379 hsa-mir-379 Epilepsies, Partial "However, pathway analysis identified ""cancer drug resistance by drug efflux"" (mir-154 and mir-379) as enriched (P = 0.02), supporting the role of drug response genes in post-operative seizure recurrence." +other 36188379 hsa-mir-154 Epilepsies, Partial "However, pathway analysis identified ""cancer drug resistance by drug efflux"" (mir-154 and mir-379) as enriched (P = 0.02), supporting the role of drug response genes in post-operative seizure recurrence." +circulation_biomarker_diagnosis_up 36188229 hsa-mir-19b Breast Neoplasms Results: In the screening phase, 5 circulating miRNAs (miR-16, miR-17, miR-19b, miR-27a, and miR-106a) were identified as the most significantly upregulated miRNAs in plasma of BC patients. Conclusion: The current study developed a miR-19b-based 3-miRNA model holding potential for diagnosis of BC using blood samples. +other 36187569 hsa-mir-424 Gram-Negative Bacterial Infections The duplex test, including miR-424 and CRP, has a diagnostic value for detecting the high risk of post-transplant gram-negative bacteremia in heart and lung transplant recipients. +epigenetics 36187230 hsa-mir-194 Ovarian Neoplasms CONCLUSION: Our work demonstrates that lncRNA DARS-AS1 promotes OC progression by modulating TSPAN1 and ITGA2 hypomethylation by binding with miR +genetics_knock down_promote 36187163 hsa-mir-155 Pancreatitis Multivariate analysis showed that the BISAP score, BUN, Leukocytes, age and CRP were independent risk factors for progression to SAP among AP patients after adjusting for hypertension, ICU admission, hospital stay and Fibrinogen, while miR-155 was a protective factor. +other 36187128 hsa-mir-503 Diabetes Mellitus, Type 2 We propose five circRNAs (hsacirc_028744, hsacirc_037219, hsacirc_006308, hsacirc_013887, and hsacirc_045622), six lncRNAs (EPB41L4A-AS1, LINC00969, GAS5, MIR4435-1HG, MIR503HG, and SNHG16), and seven mRNAs (RAB37, CCR7, CD3D, TRAT1, VWF, ICAM2, and TMEM244) as potential biomarkers related to the progression of T2DM complicated with CAP. +other 36187128 hsa-mir-503 Carotid Artery Diseases We propose five circRNAs (hsacirc_028744, hsacirc_037219, hsacirc_006308, hsacirc_013887, and hsacirc_045622), six lncRNAs (EPB41L4A-AS1, LINC00969, GAS5, MIR4435-1HG, MIR503HG, and SNHG16), and seven mRNAs (RAB37, CCR7, CD3D, TRAT1, VWF, ICAM2, and TMEM244) as potential biomarkers related to the progression of T2DM complicated with CAP. +other 36187128 hsa-mir-4435-1 Carotid Artery Diseases We propose five circRNAs (hsacirc_028744, hsacirc_037219, hsacirc_006308, hsacirc_013887, and hsacirc_045622), six lncRNAs (EPB41L4A-AS1, LINC00969, GAS5, MIR4435-1HG, MIR503HG, and SNHG16), and seven mRNAs (RAB37, CCR7, CD3D, TRAT1, VWF, ICAM2, and TMEM244) as potential biomarkers related to the progression of T2DM complicated with CAP. +other 36187128 hsa-mir-4435-1 Diabetes Mellitus, Type 2 We propose five circRNAs (hsacirc_028744, hsacirc_037219, hsacirc_006308, hsacirc_013887, and hsacirc_045622), six lncRNAs (EPB41L4A-AS1, LINC00969, GAS5, MIR4435-1HG, MIR503HG, and SNHG16), and seven mRNAs (RAB37, CCR7, CD3D, TRAT1, VWF, ICAM2, and TMEM244) as potential biomarkers related to the progression of T2DM complicated with CAP. +transcription factor target 36186733 hsa-mir-642a Inflammation These results suggest that miR-642a-5p can inhibit the inflammation by suppressing the TLR4 signalling pathway in THP-1 cells. +other 36186733 hsa-mir-642a Inflammatory Bowel Disease 11 Our previous studies have shown that the expression of miR-642a-5p is downregulated in UC with GCR, suggesting that miR-642a-5p may be related to the GC response. +circulation_biomarker_diagnosis_down 36186733 hsa-mir-642a Glucocorticoid Receptor Deficiency Our previous studies have shown that the expression of miR-642a-5p is downregulated in UC with GCR, suggesting that miR-642a-5p may be related to the GC response. We found that after treatment with miR-642a-5p mimics and DEX, the expression levels of glucocorticoid receptor (GR) in the nucleus and NF-kappaB p65 and p50 in the cytoplasm were increased (P < 0.05). +circulation_biomarker_prognosis_ns 36186528 hsa-mir-34a Respiratory Distress Syndrome, Newborn CONCLUSION: Serum miR-34a, Ang-1, and NCIS are closely related to the severity and prognosis of neonatal RDS. +other 36186470 hsa-mir-378f Diabetic Retinopathy 3p and -665 can be used as powerful markers for DR diagnosis, and the ceRNA network: lncRNA FBXL19-AS1/UBL7-AS1-miR-378f-MRPL39 may represent an important regulatory role in DR progression. +genetics_knock down_promote 36186461 hsa-mir-466 Non-alcoholic Fatty Liver Disease These findings suggest that loss of LNCPINT-derived circRNAs may underlie NAFLD via miR-466i-3p- and miR-669c-3p-dependent inactivation of the AMPK signaling pathway. +genetics_knock down_promote 36186461 hsa-mir-669c Non-alcoholic Fatty Liver Disease These findings suggest that loss of LNCPINT-derived circRNAs may underlie NAFLD via miR-466i-3p- and miR-669c-3p-dependent inactivation of the AMPK signaling pathway. +epigenetics 36186442 hsa-mir-21 Carcinoma, Renal Cell High PRKCE methylation levels and hsa-miR5p may contribute to PRKCE low expression in KIRC. +other 36186432 hsa-mir-17 Peripheral Arterial Occlusive Disease 1 Conclusion: In general, we proposed that the immune-related core ceRNA network (LINC00221, miR5p, miR-20b-5p, and CREB1) and infiltrating immune cells (monocytes and M1 macrophages) could help further explore the molecular mechanisms of PAOD. +other 36186432 hsa-mir-20b Peripheral Arterial Occlusive Disease 1 Conclusion: In general, we proposed that the immune-related core ceRNA network (LINC00221, miR5p, miR-20b-5p, and CREB1) and infiltrating immune cells (monocytes and M1 macrophages) could help further explore the molecular mechanisms of PAOD. +genetics_knock down_promote 36186122 hsa-mir-124 Cognition Disorders Here we reported age-related loss of miR-124 in human and rat brains. Our work suggested that age-related cognitive decline, at least in part, was associated with miR-124 deficiency and subsequently upregulated RyR3 expression in inducing neuronal death. +exosome 36185995 hsa-mir-10b Colorectal Neoplasms Exosomal miR5p and miR-10b-5p expression levels were increased in healthy donors compared with CRC patients in the GSE71008 dataset, and five DEmRNAs (TOMM70A, RBM48, BEND3, RHOBTB1, and ADAMTS2) were significantly upregulated in TCGA database. +exosome 36185995 hsa-mir-150 Colorectal Neoplasms Exosomal miR5p and miR-10b-5p expression levels were increased in healthy donors compared with CRC patients in the GSE71008 dataset, and five DEmRNAs (TOMM70A, RBM48, BEND3, RHOBTB1, and ADAMTS2) were significantly upregulated in TCGA database. +other 36185765 hsa-mir-363 Ischemic Stroke This included five for apoptosis (lncRNA deleted in lymphocytic leukemia 2 like (DLEU2L)/micro (miR)-4500/sulfite oxidase, lncRNA DLEU2L/miR-4500/transforming growth factor beta receptor III, lncRNA DLEU2L/miR-4500/BTB and CNC homology 1 (BACH1), lncRNA DLEU2L/miR-4500/zinc finger and BTB domain containing 5 and lncRNA LINC00266-1/miR3p/zinc finger protein 354B and two for ferroptosis (lncRNA DLEU2L/miR-4500/ribo-nucleotide reductase regulatory subunit M2 and lncRNA DLEU2L/miR-4500/BACH1). +other 36185765 hsa-mir-4500 Ischemic Stroke This included five for apoptosis (lncRNA deleted in lymphocytic leukemia 2 like (DLEU2L)/micro (miR)-4500/sulfite oxidase, lncRNA DLEU2L/miR-4500/transforming growth factor beta receptor III, lncRNA DLEU2L/miR-4500/BTB and CNC homology 1 (BACH1), lncRNA DLEU2L/miR-4500/zinc finger and BTB domain containing 5 and lncRNA LINC00266-1/miR3p/zinc finger protein 354B and two for ferroptosis (lncRNA DLEU2L/miR-4500/ribo-nucleotide reductase regulatory subunit M2 and lncRNA DLEU2L/miR-4500/BACH1). +other 36185590 hsa-mir-133a Myocardial Infarction Muscle-enriched miRNAs (miR-1 and miR-133a) were correlated with cardiac necrosis protein markers and did not offer better discrimination. +other 36185590 hsa-mir-1 Myocardial Infarction Muscle-enriched miRNAs (miR-1 and miR-133a) were correlated with cardiac necrosis protein markers and did not offer better discrimination. +other 36185502 hsa-mir-384 Thyroid Neoplasms Circular RNA PVT1 promotes progression of thyroid cancer by competitively binding miR-384. +circulation_biomarker_diagnosis_down 36185088 hsa-mir-130a psoriasis 1 Circulating has-miR-130a-3p was found to have a higher level of blood in multiple tumor patients, suggesting that hsa-miR-130a-3p has the potential to be a blood biomarker for cancer risk assessment in patients with psoriasis. +circulation_biomarker_prognosis_ns 36185088 hsa-mir-130a Abnormalities, Multiple Circulating has-miR-130a-3p was found to have a higher level of blood in multiple tumor patients, suggesting that hsa-miR-130a-3p has the potential to be a blood biomarker for cancer risk assessment in patients with psoriasis. +lncRNA target 36184817 hsa-mir-140 Memory Disorders 5p inhibition enhanced Pin1 and ADAM10 mRNA expressions but has little effect on Pin1 protein level. +transcription factor target 36184552 hsa-mir-32 Atherosclerosis 5p and its predicted target gene axin interactor, dorsalization associated (AIDA) are involved in endothelial injury and inflammation. +transcription factor target 36184552 hsa-mir-32 Inflammation 5p and its predicted target gene axin interactor, dorsalization associated (AIDA) are involved in endothelial injury and inflammation. +lncRNA target 36184551 hsa-mir-6870 Coronary Artery Disease 3p regulates human EAT inflammation by targeting the Tollip-mediated JNK and NF-kappaB signaling pathways. +lncRNA target 36184541 hsa-mir-466 Myocardial Reperfusion Injury Thus, LincRNA-p21 positively regulated the expression of Nr4a2, through sponging miR-466i-5p, promoting cardiomyocyte apoptosis in myocardial I/R injury. The current study revealed a novel LincRNA-p21/miR-466i-5p/Nr4a2 pathway for myocardial I/R injury, indicating that LincRNA-p21 may serve as a potential target for future therapy. +lncRNA target 36184488 hsa-mir-214 Squamous Cell Carcinoma of Head and Neck CircFNDC3B silencing restrains the tumorigenesis of oesophageal squamous cell carcinoma through miR3p/CDC25A axis, which opens a new window to the development of novel therapeutic strategy for ESCC patients. +transcription factor target 36184123 hsa-mir-520d Osteosarcoma Our results suggests that RPS inhibits the VM formation and metastasis of OS by modulating the miR-520d-3p/MIG-7 signaling axis. +transcription factor target 36183924 hsa-mir-203 Pancreatic Carcinoma In this study we aimed to explore interaction between downregulated miR-203 and its upregulated target DUSP5 in PC. CONCLUSIONS: These findings suggest that miR-203 restrains proliferation and migration of PC cells by regulating oncogenic activity of DUSP5 in PC, thereby could be novel candidate biomarkers for PC diagnosis and treatment. +transcription factor target 36183365 hsa-mir-20 Adenocarcinoma of Lung Bioinformatics analyses suggested that SIGLEC17P might exert antioncogenic effects in LUAD through the mir +genetics_knock down_suppress 36183123 hsa-mir-1297 Glioma More importantly, under TMZ treatment, inhibition of miR-1297 attenuated TMZ treatment on glioma cells; ADM knockdown partially attenuated the effects of miR-1297 inhibition on TMZ-treated glioma cells. +genetics_overexpression_promote 36183046 hsa-mir-193a Carcinoma, Non-Small-Cell Lung We also found that restoration of miR-193a-5p rescued NSCLC cell biological functions affected by overexpression of lncRNA DLGAP1-AS1. +other 36182923 hsa-mir-222 Polycystic Ovary Syndrome 3p assisted PCOS diagnosis and predicted increased risks of diabetic and cardiovascular complications. +transcription factor target 36181964 hsa-mir-365b Alzheimer Disease Based on the evidence, we finally identified hsa-miR-365b-5p as a key target in Alzheimer's disease. CONCLUSIONS: Hsa-miR-365b-5p act as a key target in Alzheimer's disease. +circulation_biomarker_diagnosis_up 36181627 hsa-let-7c Moyamoya Disease Our results demonstrated that the TLR7 and microRNA Let-7c expression are upregulated in VSMCs and the plasma of MMD patients, respectively. +other 36181617 hsa-mir-34a Diabetes Mellitus, Type 2 After stratifying participants based on BMI, the association of miR-143 and miR-34a expressions in VAT with IR indices remained significant only in obese patients. CONCLUSION: miR-143 and miR-34a expressions in VAT were independent predictors of IR in people without diabetes, and that this association was conditional on the degree of obesity. +other 36181617 hsa-mir-143 Diabetes Mellitus, Type 2 After stratifying participants based on BMI, the association of miR-143 and miR-34a expressions in VAT with IR indices remained significant only in obese patients. CONCLUSION: miR-143 and miR-34a expressions in VAT were independent predictors of IR in people without diabetes, and that this association was conditional on the degree of obesity. +genetics_knock down_promote 36181561 hsa-mir-634 Squamous Cell Carcinoma of Head and Neck MiR-634 targeted MAP2K4 and negatively regulated MAP2K4 expression, and overexpression of miR-634 inhibited TSCC cell proliferation, migration, and invasion, while co-overexpression of MAP2K4 was able to reverse the effects of miR-634 in TSCC cells. +lncRNA target 36181383 hsa-mir-137 Inflammation CONCLUSION: CircHOMER1 promoted HG-induced HMCs oxidative stress, inflammation and ECM accumulation via the miR-137/SOX6 axis, suggesting that circHOMER1 might be a target for DN treatment. +lncRNA target 36181383 hsa-mir-137 Norrie disease In addition, miR-137 expression was negatively correlated with circHOMER1 and SOX6 expression in DN patients. CONCLUSION: CircHOMER1 promoted HG-induced HMCs oxidative stress, inflammation and ECM accumulation via the miR-137/SOX6 axis, suggesting that circHOMER1 might be a target for DN treatment. +lncRNA target 36181281 hsa-mir-665 Colorectal Neoplasms We further demonsatred that miR-665/E2F3 axis mediated the functional role of hsa_circ_0081069 in regulating the malignant phenotype of CRC cells. Targeting hsa_circ_0081069 and miR-665/E2F3 axis could serve as potential therapeutic strategies for CRC treatment. +genetics_overexpression_promote 36180981 hsa-mir-514b Carcinoma, Non-Small-Cell Lung Furthermore, overexpression of miR-514b-5p promoted NSCLC cell growth and suppressed apoptosis by inducing the activation of the phosphatidylinositol +other 36180946 hsa-mir-556 Acute Kidney Injury Urine miR3p had the potential to improve the prediction of renal recovery from severe AKI. +circRNA target 36180890 hsa-mir-409 Breast Neoplasms CONCLUSION: CircTRIM28 facilitated the BC via miR +lncRNA target 36180862 hsa-mir-107 Acute Lung Injury This study aimed to investigate the mechanism of H19 in alleviating sepsis-induced ALI through the miR-107/TGFBR3 axis. CONCLUSION: LncRNA H19 inhibited LPS-induced PMVEC apoptosis and pro-inflammatory cytokine production and attenuated sepsis-induced ALI by targeting TGFBR3 as the ceRNA of miR-107. +lncRNA target 36180862 hsa-mir-107 Sepsis This study aimed to investigate the mechanism of H19 in alleviating sepsis-induced ALI through the miR-107/TGFBR3 axis. CONCLUSION: LncRNA H19 inhibited LPS-induced PMVEC apoptosis and pro-inflammatory cytokine production and attenuated sepsis-induced ALI by targeting TGFBR3 as the ceRNA of miR-107. +other 36180575 hsa-mir-93 Retinal Vein Occlusion 5p, and hsa-mir-20a-5p) were significantly downregulated in the CRVO group. +other 36180575 hsa-mir-20a Retinal Vein Occlusion 5p, and hsa-mir-20a-5p) were significantly downregulated in the CRVO group. +other 36180575 hsa-mir-17 Retinal Vein Occlusion 5p, and hsa-mir-20a-5p) were significantly downregulated in the CRVO group. +other 36180575 hsa-mir-195 Retinal Vein Occlusion 5p, and hsa-mir-20a-5p) were significantly downregulated in the CRVO group. +other 36180575 hsa-mir-19a Retinal Vein Occlusion 5p, and hsa-mir-20a-5p) were significantly downregulated in the CRVO group. +other 36180575 hsa-mir-144 Retinal Vein Occlusion 5p, and hsa-mir-20a-5p) were significantly downregulated in the CRVO group. +other 36180575 hsa-mir-142 Retinal Vein Occlusion 5p, and hsa-mir-20a-5p) were significantly downregulated in the CRVO group. +other 36180575 hsa-mir-16 Retinal Vein Occlusion 5p, and hsa-mir-20a-5p) were significantly downregulated in the CRVO group. +other 36180561 hsa-mir-26b Obesity Obese female dogs with hypertriglyceridemia showed an increase in the sEVs concentration and in the expression of miR-132 and miR-26b in sEVs enriched fraction. +circulation_biomarker_diagnosis_up 36180561 hsa-mir-155 Obesity No changes were observed in the group of obese female dogs with normal serum biochemical profile and in relation to miR-155 expression. +other 36180561 hsa-mir-132 Obesity Obese female dogs with hypertriglyceridemia showed an increase in the sEVs concentration and in the expression of miR-132 and miR-26b in sEVs enriched fraction. +other 36180558 hsa-mir-28 Carcinoma, Renal Cell The Association Rule Mining analysis could identify miR-28 (repeat count = 2642) and CSN7A (repeat count = 5794) along with the miR-125a (repeat count = 2591) and NMD3 (repeat count = 2306) with the highest repeat counts, in the KIRC and KIRP rules, respectively. +other 36180558 hsa-mir-125a Carcinoma, Renal Cell The Association Rule Mining analysis could identify miR-28 (repeat count = 2642) and CSN7A (repeat count = 5794) along with the miR-125a (repeat count = 2591) and NMD3 (repeat count = 2306) with the highest repeat counts, in the KIRC and KIRP rules, respectively. +circulation_biomarker_diagnosis_down 36180486 hsa-mir-21 Glioblastoma We suggest that the increased exosomal miR-21 from Toxoplasma-infected BV2 microglial cells may play an important role as a cell growth promotor of U87 glioma cells through a down-regulation of anti-tumorigenic genes. +other 36180298 hsa-mir-133a-1 Diabetes Mellitus, Type 2 rs8089787 and let-7f-rs10877887 were associated with impaired cardiac diastolic function in T2DM. +other 36180298 hsa-let-7f Diabetes Mellitus, Type 2 rs8089787 and let-7f-rs10877887 were associated with impaired cardiac diastolic function in T2DM. +transcription factor target 36180007 hsa-mir-27a Thyroid Cancer, Papillary Therefore, the present study indicated that miRNA27a may aggravate brain tissue ferroptosis during ischaemic stroke, potentially by inhibiting Nrf2. +transcription factor target 36180007 hsa-mir-27a Ischemic Stroke Therefore, the present study indicated that miRNA27a may aggravate brain tissue ferroptosis during ischaemic stroke, potentially by inhibiting Nrf2. +lncRNA target 36179941 hsa-mir-103a Graves Ophthalmopathy miR-103a-3p inhibition in TGF-beta-stimulated TED orbital fibroblasts partially abolished TGF-beta-induced fibrotic alterations, as manifested by the impaired fibroblast cell viability and decreased vimentin and fibronectin levels. +lncRNA target 36179941 hsa-mir-103a Diabetic Nephropathies miR-103a-3p inhibition in TGF-beta-stimulated TED orbital fibroblasts partially abolished TGF-beta-induced fibrotic alterations, as manifested by the impaired fibroblast cell viability and decreased vimentin and fibronectin levels. +circulation_biomarker_diagnosis_ns 36178486 hsa-mir-92a Sepsis OBJECTIVE: This study attempted to investigate miR-92a-3p expression in peripheral blood of patients with severe beta-thalassemia, and the effect and action mechanism of miR-92a-3p on gamma-globin expression and oxidative stress in erythroid precursor cells. +circulation_biomarker_diagnosis_down 36178486 hsa-mir-92a Polycythemia OBJECTIVE: This study attempted to investigate miR-92a-3p expression in peripheral blood of patients with severe beta-thalassemia, and the effect and action mechanism of miR-92a-3p on gamma-globin expression and oxidative stress in erythroid precursor cells. +circulation_biomarker_diagnosis_ns 36178486 hsa-mir-92a beta-Thalassemia OBJECTIVE: This study attempted to investigate miR-92a-3p expression in peripheral blood of patients with severe beta-thalassemia, and the effect and action mechanism of miR-92a-3p on gamma-globin expression and oxidative stress in erythroid precursor cells. +circRNA target 36178207 hsa-mir-122 Uterine Cervical Neoplasms 5p competition and thus promotes the development of CC, providing a novel targeted therapy for CC. +lncRNA target 36178080 hsa-mir-144 Osteoarthritis CONCLUSION: LncRNA TM1-3P improved inflammation and damage of knee joints in OA rats through miR3p/ONECUT2 axis, providing a new theoretical basis for gene therapy of OA. +other 36177926 hsa-mir-494 Cystic Fibrosis OBJECTIVE: To observe the effects of Xiaoqinglong Decoction and Qingqi Huatan Pills on interleukin-1beta (IL-1beta)-induced mucushypersecretion model of human airway epithelial H292 cellsand related molecules of nuclear factor-kappaB/microRNA-494(NF-kappaB/miR-494) signaling pathway, and to explore the mechanism of the two medicines in improving pathological airway mucus. +transcription factor target 36177783 hsa-mir-204 Brain Injuries These results suggest that down-regulation of miR5p ameliorates sevoflurane-induced cognitive impairment and hippocampal pathology and inhibits neuronal autophagy and apoptosis by targeting VCAM1. +other 36177782 hsa-mir-16 Premature Ejaculation We aimed to determine the level of miRNAs 16 and 135a in lifelong premature ejaculation (LPE) patients versus controls. +other 36177588 hsa-mir-203a Vascular Diseases 5p mimic group, miR-203b-3p mimic group, and miR-203a-3p mimic group decreased significantly (0.516+/-0.188, 0.170+/-0.025, and 0.235+/-0.025, with t values of 3.17, 5.43, and 5.07, respectively, P<0.05 or P<0.01). +other 36177588 hsa-mir-29 Vascular Diseases 5p mimic group, miR-203b-3p mimic group, and miR-203a-3p mimic group decreased significantly (0.516+/-0.188, 0.170+/-0.025, and 0.235+/-0.025, with t values of 3.17, 5.43, and 5.07, respectively, P<0.05 or P<0.01). +circulation_biomarker_diagnosis_up 36177494 hsa-mir-125b Lupus Erythematosus, Systemic 5p and miR-125b-5p expression and its target genes NFKB1 and TRAF6 in peripheral blood samples (PBMC) from the 35 cSLE patients and 35 healthy controls. +circulation_biomarker_diagnosis_up 36177494 hsa-mir-9 Lupus Erythematosus, Systemic 5p and miR-125b-5p expression and its target genes NFKB1 and TRAF6 in peripheral blood samples (PBMC) from the 35 cSLE patients and 35 healthy controls. +transcription factor target 36177008 hsa-mir-27b Inflammatory Bowel Diseases Moreover, the marked upregulation of six miR-27b target genes (IFI16, GCA, CYP1B1, RUNX1, MEF2C and MMP13) in the inflamed colon tissues is a possible direct consequence of the lack of repression due to the downregulated miRNA-27b expression. +lncRNA target 36176750 hsa-mir-186 Mesothelioma, Malignant Conclusion: We unraveled a novel mechanism of action of butein, which attenuated the pro-tumorigenic features of MPM at least through a miR +other 36176029 hsa-mir-200b Colitis Notably, MVs from normal feces could effectively reverse the composition of the intestinal microbiota, restore the intestinal barrier and rescue colitis, and BMVs from colitis would also have similar effects after miR-200b-3p treatment. +genetics_overexpression_promote 36175984 hsa-mir-146a Spinal Cord Injuries miR-146a-5p was overexpressed in exosomes, and then, miR-146a-5p-modified exosomes were used to investigate the ability of exosomes to reduce neurotoxic astrocyte effects, preserve neurons and promote neurological function recovery in rats with SCI. +lncRNA target 36175893 hsa-mir-4741 Intervertebral Disc Degeneration 5p-IGF1/AR as important regulatory axis of IDD, which will help us gain further insight into the pathogenesis of IDD and determine potential therapeutic targets. +lncRNA target 36175893 hsa-mir-508 Intervertebral Disc Degeneration 5p-IGF1/AR as important regulatory axis of IDD, which will help us gain further insight into the pathogenesis of IDD and determine potential therapeutic targets. +lncRNA target 36175893 hsa-mir-3158 Intervertebral Disc Degeneration 5p-IGF1/AR as important regulatory axis of IDD, which will help us gain further insight into the pathogenesis of IDD and determine potential therapeutic targets. +other 36175844 hsa-mir-181a Chronic Disease CONCLUSIONS: These data support a role of miR-181a in age-related chronic inflammation and in the development of multimorbidity in older adults and indicate that the routes by which this miRNA influence health status are likely to be gender specific. +circulation_biomarker_diagnosis_up 36175844 hsa-mir-181a Aicardi-Goutieres syndrome 5 This study aimed to evaluate plasma levels of the inflamma-miR-181a in relation to age, parameters of health status (clinical, physical, and cognitive) and indices of multimorbidity in a cohort of 244 subjects aged 65- 97. CONCLUSIONS: These data support a role of miR-181a in age-related chronic inflammation and in the development of multimorbidity in older adults and indicate that the routes by which this miRNA influence health status are likely to be gender specific. +circulation_biomarker_diagnosis_up 36175844 hsa-mir-181a Multiple Chronic Conditions This study aimed to evaluate plasma levels of the inflamma-miR-181a in relation to age, parameters of health status (clinical, physical, and cognitive) and indices of multimorbidity in a cohort of 244 subjects aged 65- 97. +lncRNA target 36175700 hsa-mir-155 Leukemia, Lymphocytic, Chronic, B-Cell The results confirmed the anti-tumor impact of berberine on CLL cells through reducing CD69, Ki67, and miR-155 expression and increasing cleaved PARP1 may be considered as an option for future clinical studies. +lncRNA target 36175341 hsa-mir-339 Pain, Postoperative So, the authors hypothesized that miR5p could regulate the expression of MOR via targeting oprm1 and cause the effects to CPSP. +transcription factor target 36174767 hsa-mir-130a Osteoporosis In conclusion, PDE-induced intrauterine hypoglucocorticoid exposure could positively program IGF1 expression in bone tissue through the GRalpha/miR-130a-5p/HDAC4 pathways, thus mediating osteogenic dysdifferentiation and adult osteoporosis susceptibility in male offspring rats. +other 36174738 hsa-mir-200b Encephalomyelitis, Eastern Equine Furthermore, the expression of miR-200b-3p was increased, while that of ERG and PTHrP was markedly reduced in PEE fetal cartilage. +other 36174709 hsa-mir-148a Osteoporosis Moreover, histone acetylation of the WNT-1 gene and miR-148a-3p interference proved to play a role in the regulation of the WNT-signalling pathway during OP progression and treatment. +lncRNA target 36174668 hsa-mir-29a Parkinson Disease In conclusion, this research provides novel insight into a neuroprotective pathway of miR-29a and could thus serve as a possible therapeutic target for improving the treatment of PD. +lncRNA target 36173586 hsa-mir-101 Abortion, Habitual 3p/OTUD3 may be potential targets for the prevention of unexplained RSA. +other 36173547 hsa-mir-125a Cataract, Age-Related Nuclear METHODS: The expression of miR-125a-3p in age-related cataract (ARC) specimens and cell models was detected by qRT-PCR. +other 36173547 hsa-mir-125a AIDS-Related Complex METHODS: The expression of miR-125a-3p in age-related cataract (ARC) specimens and cell models was detected by qRT-PCR. RESULTS: miR-125a-3p was upregulated in ARC tissues and LECs treated with UVB. +lncRNA target 36173547 hsa-mir-125a Cataract METHODS: The expression of miR-125a-3p in age-related cataract (ARC) specimens and cell models was detected by qRT-PCR. CONCLUSION: This study indicated that miR-125a-3p regulated apoptosis by suppressing TMBIM4 in LECs under oxidative damage, providing a new idea for clinical therapeutic target of cataract. +other 36173063 hsa-let-7b Melanoma CONCLUSION: In conclusion, we elucidated the regulatory role of the SNHG16-hsa-let-7b-5p-TUBB4A axis in the progression of skin cutaneous melanoma by modulating mitochondrial function to affect cellular metabolism. +genetics_overexpression_promote 36173030 hsa-mir-22 Colorectal Neoplasms 3p in CRC reduced YAP1 expression, whereas overexpression of KDM3A restored the expression of YAP1. +other 36173004 hsa-mir-210 Uterine Cervical Neoplasms 3p and modulates the progression of cervical cancer, which predict the prognosis of cervical cancer patients. +lncRNA target 36172919 hsa-mir-1 Carcinoma, Non-Small-Cell Lung The QKI-5 expression was anticorrelated with the miR-31 expression in NSCLC patient samples. CONCLUSION: Our results suggest that the miR-31/QKI-5/p21-CDK4-CDK6 axis might have critical functions in the progression of NSCLC, and targeting this axis could serve as a potential therapeutic strategy for NSCLC. +other 36172827 hsa-mir-485 Colorectal Neoplasms CONCLUSION: Circ_0001535 promotes colorectal cancer cell development by absorbing miR5p and upregulating LASP1. +other 36172678 hsa-mir-409 Lung Neoplasms CONCLUSION: miR3p may prevent non-small cell lung cancer (NSCLC) by affecting ELF2 transcription and other cellular regulators to regulate A549 cell division and induce apoptosis. +other 36172578 hsa-mir-370 Myocardial Reperfusion Injury This study revealed that the lncRNA-HRAT/miR3p/RNF41 pathway regulates cardiomyocyte apoptosis and myocardial injury. +other 36172547 hsa-mir-192 Wounds and Injuries 5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma. +other 36172547 hsa-mir-223 Wounds and Injuries 5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma. +other 36172547 hsa-mir-26b Wounds and Injuries 5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma. +other 36172547 hsa-mir-16-2 Wounds and Injuries 5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma. +other 36172547 hsa-mir-185 Wounds and Injuries 5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma. +other 36172547 hsa-mir-485 Wounds and Injuries 5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma. +other 36172547 hsa-mir-197 Wounds and Injuries 5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma. +other 36172547 hsa-mir-16 Wounds and Injuries 5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma. +other 36172547 hsa-mir-23a Wounds and Injuries 5p) were significantly upregulated, while 58 mRNAs were significantly downregulated in T cells following major trauma. +genetics_GWAS 36172375 hsa-mir-146a Autoimmune Diseases Our work highlights the pathogenetic role of miR-146a and the potential of pharmacologic inhibition of TRAF6 in autoimmune diseases in which miR-146a is deregulated. +lncRNA target 36172098 hsa-mir-668 Alzheimer Disease 3p may be a potential therapeutic target for AD. +other 36172090 hsa-mir-149 Breast Neoplasms Rutaecarpine prevents the malignant biological properties of breast cancer cells by the miR-149-3p/S100A4 axis. +other 36171887 hsa-mir-203a Breast Neoplasms An mRNA-miRNA network was built to identify an miR-203a-3p/LDHD/LYRM7 regulatory axis in BC. +other 36171576 hsa-mir-126 Adenocarcinoma of Lung Transduction of miR3p is a potential therapeutic strategy for treating LUAD, yet the physiological environment and properties of miRNA challenge current transduction approaches. +other 36171191 hsa-mir-132 Neurotic Disorders 5p in the PFC underlying depression-like phenotypes in CRS model and the sustained prophylactic effects of (R)-ketamine. +other 36171191 hsa-mir-132 Rubella Syndrome, Congenital 5p in the PFC underlying depression-like phenotypes in CRS model and the sustained prophylactic effects of (R)-ketamine. +circRNA target 36171087 hsa-mir-647 Vascular Diseases Circular RNA hsa_circ_0000345 (circ_0000345) and miR-647 are related to oxygenized low-density lipoprotein (ox-LDL)-induced arterial smooth muscle cell (ASMC) dysregulation. +genetics_overexpression_promote 36171087 hsa-mir-647 Angelman Syndrome Mechanistically, circ_0000345 was verified as a miR-647 sponge, and miR-647 overexpression impaired the inhibitory effects of circ_0000345 upregulation on ox-LDL-induced ASMC proliferation, migration, invasion, and inflammatory response. +lncRNA target 36170021 hsa-mir-136 Carcinoma, Renal Cell CONCLUSIONS: Our findings suggested that lncRNA NLGN1-AS1 could promote the progression of ccRCC by targeting miR5p/FZD4 and Wnt/beta-catenin pathway, and might serve as a novel potential therapeutic target to inhibit the progression of ccRCC. +genetics_knock down_suppress 36169673 hsa-mir-466f Osteoporosis * Knockdown of lncRNA NEAT1 inhibited osteoblast cells autophagy by sponging miRNA-466f-3p and targeting HK2 in osteoporosis. +other 36169175 hsa-mir-675 Adrenocortical Carcinoma The downregulated expression of H19 in ACC compared to ACA correlated with miR675 expression hosted by H19. +genetics_knock down_promote 36169092 hsa-mir-506 Carcinoma, Hepatocellular In HSC-CM cultured HCC cells, the effects of MIR4435-2HG knockdown on TGFB1 expression and HCC cell phenotypes were partially reversed by miR +other 36168936 hsa-mir-29a Uterine Cervical Neoplasms In conclusion, circ_0072995 promoted cervical cancer development by inducing miR-29a-mediated WDR5 expression.Impact statementWhat is already known on this subject? Global Cancer Statistics 2020 estimated that there were 1 021,494 new cases of cervical cancer and 439 201 deaths from cervical cancer. We first reported the promoting effects of circ_0072995 in cervical cancer development by inducing miR-29a mediated WDR5 expression and also revealed the therapeutic potential of circ_0072995, miR-29a, and WDR5 in cervical cancer. +lncRNA target 36168877 hsa-mir-18a Ischemic Stroke Promoting Role of Long Non-Coding RNA Small Nucleolar RNA Host Gene 15 (SNHG15) in Neuronal Injury Following Ischemic Stroke via the MicroRNA-18a/CXC Chemokine Ligand 13 (CXCL13)/ERK/MEK Axis. +lncRNA target 36168858 hsa-mir-144 Osteoporosis, Diabetic In conclusion, this study indicated that HG regulated the migration, proliferation, and mineralization of osteoblasts via the miRNA +other 36168845 hsa-mir-619 Biliary Tract Neoplasms 3p represents a potentially valuable diagnostic strategy for identifying BTCs as well as a predictive indicator of BTC prognosis. +other 36168417 hsa-mir-122 Diabetes Mellitus, Type 2 The relationship of miR-126 and miR-122 expression with T2DM risk and these glucose metabolism parameters may be influenced by study types, sample size, different source and mean age of participants. In conclusion, in the general healthy population, higher miR-126 expression was related to lower T2DM risk, FBG level and HOMA-IR index; higher miR-122 expression was closely correlated with higher FBG level and HOMA-IR index. +other 36167817 hsa-mir-26a Respiratory Sounds "RESULTS: Two infant factors (daycare attendance, family history of asthma) and three salivary ""omic"" features (miR-26a-5p, Elusimicrobia, Streptococcus phage phiARI0131-1) differed between the two groups (adjusted p < 0.05)." +circulation_biomarker_diagnosis_up 36167754 hsa-mir-182 high grade glioma The proposed method was highly selective and possessed remarkable capability for evaluating the expression levels of miRNA-182 in serum samples from healthy donors and glioma patients. +lncRNA target 36167718 hsa-mir-451 Osteoarthritis Moreover, when osteoarthritis (OA) was induced in Sprague Dawley rats via bilateral anterior cruciate ligament transection (ACLT), miR-451 expression was increased in OA cartilage compared to control, suggesting its inhibition might be used to prevent or treat OA. To examine the prophylactic and therapeutic potential of inhibiting miR-451, we evaluated treatment with miR-451 power inhibitor (451-PI) at the onset of joint trauma and treatment after OA had developed. +other 36167680 hsa-mir-890 Hemangioma, Cavernous Moreover, increased Circ_0000915 and RNF187 levels were observed in IH tissues and positively associated with propranolol resistance, miR-890 exhibited an inverse expression pattern. CONCLUSION: We thereby uncover the activation of IL-6/STAT3/Circ_0000915/miR-890/RNF187 axis in propranolol resistance of IH, and provide therapeutic implications for patients of IH with propranolol resistance. +other 36167680 hsa-mir-890 Hemangioma Moreover, increased Circ_0000915 and RNF187 levels were observed in IH tissues and positively associated with propranolol resistance, miR-890 exhibited an inverse expression pattern. CONCLUSION: We thereby uncover the activation of IL-6/STAT3/Circ_0000915/miR-890/RNF187 axis in propranolol resistance of IH, and provide therapeutic implications for patients of IH with propranolol resistance. +circulation_biomarker_diagnosis_up 36166353 hsa-mir-199a Diabetic Neuropathies Regarding the association between endoplasmic reticulum (ER) stress with the pathogenesis of neuropathy, this study aims to examine binding immunoglobulin protein (BiP) gene expression and long noncoding RNA nuclear enriched abundant transcript 1 (NEAT1), miR-199a-5 as its regulator in the peripheral blood of DN patients compared to diabetic patients without neuropathy. +other 36165177 hsa-mir-96 Crohn Disease 5p had a better performance in recognizing active Crohn's disease with AUROC of 0.727 (95%CI 0.609-0.844, p = .001) than C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and fecal calprotectin. +epigenetics 36165173 hsa-mir-1246 Lupus Erythematosus, Systemic We found that increased histone H3 trimethylation at Lys(27) (H3K27me3) and decreased histone H3 acetylation at Lys(9) and Lys(14) (H3K9/K14ac) in the miR-1246 promoter region are essential for the low expression of miR-1246 in SLE B cells. +other 36164970 hsa-mir-125a Lupus Erythematosus, Systemic In conclusion, hsa_circ_0012919 regulated the pyroptosis in the CD4+ T cells of SLE patients by miR-125a-3p/GSDMD axis. +circulation_biomarker_diagnosis_ns 36164928 hsa-mir-296 Diabetes, Gestational 3p in peripheral blood samples from patients with GDM were measured using reverse transcription-quantitative polymerase chain reaction. +other 36164909 hsa-mir-20 Myocardial Reperfusion Injury Compared with the sham group, the modeling of IR increased the myocardial infarction area, LVIDd, LVIDs, and myocardial pathology and down-regulated the expression of miR-20 b-5 p(P<0.05). The IR+RES+miR-20 b-5 p antagomir group had higher myocardial infarction area, LVIDd, LVIDs, and myocardial pathology and lower expression of miR-20 b-5 p than the IR+RES group(P<0.05). +genetics_knock down_promote 36164726 hsa-mir-656 Carcinoma, Non-Small-Cell Lung 3p downregulation or xCT overexpression partly overturned hsa_circ_0018189 knockdown or miR +lncRNA target 36164699 hsa-mir-338 Osteosarcoma 3p, which could be a new target for OS treatments. +other 36164683 hsa-mir-106b Arthritis, Rheumatoid The qRT-PCR results indicated that the expression of lncRNA HOTAIR was markedly decreased and that of miR-106b-5p was markedly increased in HFLSs of RA. +other 36164637 hsa-mir-223 Sepsis CONCLUSION: Our study shows that all tested miRNAs can be used for early detection of sepsis, with miRNA-223 being predictive of mortality, hence preventing multi-organ failure and reducing mortality, and predicting poor outcomes, thereby assisting in early categorization of ICU patients for rapid appropriate treatment and medico legal aspects. +circRNA target 36164444 hsa-mir-146b Colorectal Neoplasms Rescue assays demonstrated circZC3HAV1 sponged miR-146b-3p and upregulated TBC1D9 to restrict migration and invasion of CRC cells. CONCLUSION: circZC3HAV1 could upregulate TBC1D9 via absorbing miR-146b-3p, consequently inhibiting migratory and invasive capabilities of CRC cells. +other 36164345 hsa-mir-187 Stomach Neoplasms miR-187/PDLIM1 Gets Involved in Gastric Cancer Progression and Cisplatin Sensitivity of Cisplatin by Mediating the Hippo-YAP Signaling Pathway. +genetics_overexpression_promote 36164322 hsa-mir-452 Carcinoma, Hepatocellular The effects of HCC cell-derived exosomes on accelerating HCC migration and invasion and inducing M2 macrophage polarization were confirmed, which were further enhanced after overexpressing miR +transcription factor target 36163623 hsa-mir-153 Sepsis Conclusion LPS induces increased expression of miR-153 in lung tissue, inhibits APC expression, promotes apoptosis, oxidative stress and inflammatory response in lung tissue of septic rats, and aggravates damage. +transcription factor target 36163623 hsa-mir-153 Lung Injury Conclusion LPS induces increased expression of miR-153 in lung tissue, inhibits APC expression, promotes apoptosis, oxidative stress and inflammatory response in lung tissue of septic rats, and aggravates damage. +lncRNA target 36163622 hsa-mir-1 Sepsis Objective To investigate whether long non-coding RNA-HOX transcript antisense intergenic RNA (lncRNA-HOTAIR) regulates the inflammatory response of sepsis by targeting microRNA miR3p. +lncRNA target 36162992 hsa-mir-575 Esophageal Squamous Cell Carcinoma Mechanistically, RPL34-AS1 acted as a competing endogenous RNA (ceRNA) of miR-575 to relieve the repressive effect of miR-575 on its target ACAA2, then suppressed the tumorigenesis of ESCC. +transcription factor target 36162691 hsa-mir-146a Depression We also observed 74 miRNAs associated with depression that are targeted by curcumin, with hsa-miR-146a-5p having the greatest expression and interaction. +other 36162484 hsa-mir-205 Breast Neoplasms MiR-205 and HELLS could be considered a novel diagnosis and therapeutic molecular marker of breast cancer. +other 36162459 hsa-mir-200a Diabetes Mellitus Furthermore, circSCMH1 was observed to induce HG cell growth and EMT by regulating the miR-200a-3p/ZEB1 axis. +genetics_overexpression_promote 36162436 hsa-mir-382 Squamous Cell Carcinoma of Head and Neck In addition, overexpression of miR +lncRNA target 36162418 hsa-mir-144 Polycystic Ovary Syndrome The aim of this study was to examine the impact of miR-144 and miR-224 and their candidate target genes (COX-2 and PTX-3 , respectively) expression on oocyte development in PCOS patients. +lncRNA target 36162418 hsa-mir-224 Polycystic Ovary Syndrome The aim of this study was to examine the impact of miR-144 and miR-224 and their candidate target genes (COX-2 and PTX-3 , respectively) expression on oocyte development in PCOS patients. +other 36162367 hsa-mir-423 Pulmonary Disease, Chronic Obstructive 5p is a potential marker for identifying COPD patients. +other 36161443 hsa-mir-206 Heart Failure 5p) identified HFpEF cases with a sensitivity of 0.82 and a specificity of 0.61. +other 36161443 hsa-mir-375 Heart Failure 5p) identified HFpEF cases with a sensitivity of 0.82 and a specificity of 0.61. +other 36161443 hsa-mir-19b Heart Failure 5p) identified HFpEF cases with a sensitivity of 0.82 and a specificity of 0.61. +other 36161443 hsa-mir-424 Heart Failure 5p) identified HFpEF cases with a sensitivity of 0.82 and a specificity of 0.61. +other 36161443 hsa-mir-221 Heart Failure 5p) identified HFpEF cases with a sensitivity of 0.82 and a specificity of 0.61. +other 36161443 hsa-mir-28 Heart Failure 5p) identified HFpEF cases with a sensitivity of 0.82 and a specificity of 0.61. +genetics_knock down_promote 36161346 hsa-mir-508 Breast Neoplasms CONCLUSION: Knockdown of hsa_circ_0002082 suppresses breast cancer growth and metastasis by miR3p/CENPF axis, suggesting that hsa_circ_0002082 may be a promising target for breast cancer treatment. +epigenetics 36161330 hsa-mir-193 Pituitary Neoplasms In pituitary carcinomas, methylation of autosomal genes PARP15, LINC00599, MIR193 and ZAP70 was higher than in PAs/PITNETs, while X-linked genes methylation level was lower. +lncRNA target 36161300 hsa-mir-144 Uterine Cervical Neoplasms CONCLUSION: Silencing circPUM1 may inhibit the proliferation, colony formation, migration, invasion and induce apoptosis of cervical cancer cells through targeting and regulating the expression of miR +transcription factor target 36161100 hsa-mir-4739 Osteoporosis CONCLUSIONS: Overall, we proved that the higher expression of miR-4739 participated in the progression of osteoporosis by targeting ITGA10 and modulating PI3K/AKT signaling pathway, and perhaps miR-4739/ITGA10 axis could be potential diagnostic markers and therapeutic target for osteoporosis. +lncRNA target 36161098 hsa-mir-223 Myocardial Infarction 3p is a potential target for the treatment of myocardial infarction (MI). +genetics_knock down_suppress 36160904 hsa-mir-122 Osteochondritis Dissecans 5p and the knockdown of NDRG3 reversed the inhibitory effects of Meg3 overexpression on the proliferation, migration and angiogenesis of hCMEC/D3 cells subjected to OGD, as well as the promoting effects of Meg3 overexpression on cell apoptosis. +genetics_knock down_suppress 36160896 hsa-mir-3160 Lymphoma, Large B-Cell, Diffuse Overall, the present study revealed that CACNA1G-AS1-knockdown and miR +transcription factor target 36160881 hsa-mir-146a Inflammatory Bowel Diseases At present, the biogenesis, function and role of miR-146a-5p in intestinal epithelial cells (IECs) during the pathogenesis of IBD remain elusive. Therefore, miR-146a-5p may act as an important diagnostic biomarker and treatment target of IBD. +lncRNA target 36160704 hsa-mir-372 Diabetic Cardiomyopathies 3p KD inhibits the development of DCM via activating the PI3K/AKT/mTOR/HIF-1alpha signaling pathway or suppressing oxidative stress. +lncRNA target 36160704 hsa-mir-372 Brain Ischemia 3p KD inhibits the development of DCM via activating the PI3K/AKT/mTOR/HIF-1alpha signaling pathway or suppressing oxidative stress. +other 36160329 hsa-mir-124 Spinal Cord Injuries METHODS: Five hundred and twenty-eight spinal cord injury (SCI) patients were genotyped for the analysis of the effect of rs531564 upon the miR-124 expression. CONCLUSIONS: rs531564 could affect the expression of BIM by reducing the expression of miR-124, and it could be a bio-marker for the length of recovery after SCI. +lncRNA target 36160034 hsa-mir-182 Colorectal Neoplasms Through the lncRNA-miRNA-mRNA network, 3 miRNAs (miR3p, miR-4506, and miR-3182), 7 prognostic mRNAs (ALPG, DTX1, HOXD13, RIMS3, SLC16A8, SYT1, and TNNT1), and 2 key mRNAs (RIMS3 and SLC16A8) were determined to participate in the inhibitory mechanism of beta-elemene in CRC. +lncRNA target 36160034 hsa-mir-4506 Colorectal Neoplasms Through the lncRNA-miRNA-mRNA network, 3 miRNAs (miR3p, miR-4506, and miR-3182), 7 prognostic mRNAs (ALPG, DTX1, HOXD13, RIMS3, SLC16A8, SYT1, and TNNT1), and 2 key mRNAs (RIMS3 and SLC16A8) were determined to participate in the inhibitory mechanism of beta-elemene in CRC. +lncRNA target 36160034 hsa-mir-7109 Colorectal Neoplasms Through the lncRNA-miRNA-mRNA network, 3 miRNAs (miR3p, miR-4506, and miR-3182), 7 prognostic mRNAs (ALPG, DTX1, HOXD13, RIMS3, SLC16A8, SYT1, and TNNT1), and 2 key mRNAs (RIMS3 and SLC16A8) were determined to participate in the inhibitory mechanism of beta-elemene in CRC. +other 36160032 hsa-mir-4462 Breast Neoplasms In this study, after performing GSEA and microarray analysis on the GSE71053 dataset, a new ceRNA network of CCDC18-AS1, LINC01343, hsa-miR4462, and SFN in BC was detected by bioinformatics analysis. +other 36160019 hsa-mir-133 childhood acute myeloid leukemia hsa-miR-133, hsa-miR-181, and hsa-miR-195 were significantly downregulated +other 36160019 hsa-mir-195 childhood acute myeloid leukemia hsa-miR-133, hsa-miR-181, and hsa-miR-195 were significantly downregulated +other 36160019 hsa-mir-181 childhood acute myeloid leukemia hsa-miR-133, hsa-miR-181, and hsa-miR-195 were significantly downregulated +other 36159813 hsa-mir-29c Head and Neck Neoplasms Moreover, the LINC01270/hsa-miR-29c-3p/SFXN3 axis was identified as the most likely upstream non-coding RNA-related pathway of SFXN3 in HNSC using bioinformatic analysis, expression analysis, correlation analysis, and survival analysis. +lncRNA target 36159784 hsa-mir-3061 Intestinal Diseases CONCLUSION: This study elucidated that diabetes exacerbated sepsis-induced intestinal injury by promoting M1 macrophage polarization and further demonstrated that the miR-3061/Sani1 axis may be the potential target of macrophage polarization. +lncRNA target 36159784 hsa-mir-3061 Sepsis CONCLUSION: This study elucidated that diabetes exacerbated sepsis-induced intestinal injury by promoting M1 macrophage polarization and further demonstrated that the miR-3061/Sani1 axis may be the potential target of macrophage polarization. +lncRNA target 36159784 hsa-mir-3061 Diabetes Mellitus CONCLUSION: This study elucidated that diabetes exacerbated sepsis-induced intestinal injury by promoting M1 macrophage polarization and further demonstrated that the miR-3061/Sani1 axis may be the potential target of macrophage polarization. +lncRNA target 36159592 hsa-mir-106b Muscular Dystrophy, Duchenne This study demonstrates that miR-106b is an important modulator of SC quiescence, and that miR-106b may be a new target to develop therapeutic strategies to promote muscle regeneration improving the regenerative capabilities of injured dystrophic muscle. +circRNA target 36159584 hsa-mir-140 Osteoarthritis CONCLUSION: The upregulation of circKMT2E is involved in the chondrocyte apoptosis of the pathogenesis of OA through activation of TLR4 by the sponge function of miR +target gene 36159567 hsa-mir-135a Liver Neoplasms HBV Promotes the Proliferation of Liver Cancer Cells through the hsa_circ_0000847/miR-135a Pathway. +transcription factor target 36159559 hsa-mir-132 Cognition Disorders Herein, whether electroacupuncture (EA) helps alleviate cognitive impairment in REMSD by targeting miR-132 was assessed. Agomir or antagomir of MiR-132 was injected into the hippocampal CA1 areas to assess the EA mechanism in rats with REMSD. +transcription factor target 36159559 hsa-mir-132 REM Sleep Behavior Disorder Herein, whether electroacupuncture (EA) helps alleviate cognitive impairment in REMSD by targeting miR-132 was assessed. Agomir or antagomir of MiR-132 was injected into the hippocampal CA1 areas to assess the EA mechanism in rats with REMSD. +transcription factor target 36159559 hsa-mir-13 REM Sleep Behavior Disorder Herein, whether electroacupuncture (EA) helps alleviate cognitive impairment in REMSD by targeting miR-132 was assessed. The current data demonstrate that EA at GV20 and GV14 attenuates cognitive impairment and modulates synaptic plasticity in hippocampal neurons via miR-132 in a sleep-deprived rat model. +transcription factor target 36159559 hsa-mir-13 Cognition Disorders Herein, whether electroacupuncture (EA) helps alleviate cognitive impairment in REMSD by targeting miR-132 was assessed. The current data demonstrate that EA at GV20 and GV14 attenuates cognitive impairment and modulates synaptic plasticity in hippocampal neurons via miR-132 in a sleep-deprived rat model. +genetics_overexpression_suppress 36158838 hsa-mir-194 Angelman Syndrome Overall, the current study demonstrated that LINC00452 overexpression reversed oxLDL-induced growth inhibition of HUVECs via regulating the miR5p/IGF1R axis, thus providing a potential beneficial targets for AS. +exosome 36158698 hsa-mir-1246 Squamous Cell Carcinoma of Head and Neck Phenformin suppresses angiogenesis through the regulation of exosomal microRNA-1246 and microRNA-205 levels derived from oral squamous cell carcinoma cells. +circulation_biomarker_diagnosis_down 36158656 hsa-mir-625 Neuroendocrine Tumors CONCLUSIONS: Our study suggests that expression of plasma miRNAs miR +genetics_overexpression_promote 36158629 hsa-mir-26a Carcinoma, Hepatocellular miR-26a overexpression broadly inhibited the inflammatory response in both hepatocytes and macrophages by decreasing several key oncogenic signaling pathways in HCC promotion. +lncRNA target 36157880 hsa-mir-106a Glioma Further research showed that DCs after miR-106a/20b-mimics transfection could promote the inhibition of GSC proliferation by T cells in vitro and suppress tumour growth in vivo. +other 36157872 hsa-mir-326 Carcinoma, Hepatocellular CONCLUSION: We conclude that miRNA-326, miRNA-424, and miRNA-511 have diagnostic and prognostic roles in Egyptian patients with hepatitis C virus-related HCC and should be considered for better disease management. +other 36157872 hsa-mir-424 Carcinoma, Hepatocellular CONCLUSION: We conclude that miRNA-326, miRNA-424, and miRNA-511 have diagnostic and prognostic roles in Egyptian patients with hepatitis C virus-related HCC and should be considered for better disease management. +circulation_biomarker_prognosis_up 36157872 hsa-mir-511 Carcinoma, Hepatocellular AIM: To assess the role of circulating miRNAs-326, miRNA-424, and miRNA-511 in Egyptian HCC patients. +other 36157551 hsa-mir-423 Carcinoma, Hepatocellular In the training cohort, only miR-21, miR-320d and miR-423 could significantly distinguish (Q < 0.05) between the HCC and chronic liver disease control groups. In the validation cohort, only miR-21 and miR-423 could be confirmed as potential HCC biomarkers. +other 36157551 hsa-mir-320d Carcinoma, Hepatocellular In the training cohort, only miR-21, miR-320d and miR-423 could significantly distinguish (Q < 0.05) between the HCC and chronic liver disease control groups. +other 36157551 hsa-mir-21 Carcinoma, Hepatocellular In the training cohort, only miR-21, miR-320d and miR-423 could significantly distinguish (Q < 0.05) between the HCC and chronic liver disease control groups. +other 36157524 hsa-mir-3682 Carcinoma, Hepatocellular 3p may represent a novel therapeutic strategy for HCC. +other 36157241 hsa-mir-26a Stomach Neoplasms Finally, we determined that the Taurine Upregulated 1 (TUG1)/hsa-miR-26a-5p/EIF4G2 axis was the most likely regulatory pathway involved in GC development. The TUG1/hsa-miR-26a-5p axis is a likely upstream regulatory mechanism of EIF4G2 in GC. +other 36157234 hsa-mir-375 Carcinoma, Hepatocellular lncRNA TINCR Regulates Proliferation and Invasion of Hepatocellular Carcinoma Cells by Regulating the miR-375/ATG7 Axis. +lncRNA target 36157217 hsa-mir-520g Triple Negative Breast Neoplasms TFF1, hsa-miR-520g-3, and hsa-miR-520h may serve as the novel therapeutic targets, and our findings offer further insights into the therapy of AR-positive TNBC. +lncRNA target 36157217 hsa-mir-520h Triple Negative Breast Neoplasms TFF1, hsa-miR-520g-3, and hsa-miR-520h may serve as the novel therapeutic targets, and our findings offer further insights into the therapy of AR-positive TNBC. +genetics_overexpression_promote 36156852 hsa-mir-506 Colorectal Neoplasms AKT2 overexpression or miR +target gene 36156333 hsa-mir-506 Breast Neoplasms MicroRNA-506 ameliorates breast cancer-induced osteolytic bone metastasis via the NFATc-1 signaling pathway. +lncRNA target 36156291 hsa-mir-599 Angelman Syndrome CONCLUSION: Our findings illustrated that curcumin exhibited anti-AS effect through the miR-599/MYD88 axis and thereby inhibiting the NF-kappaB pathway. +lncRNA target 36156150 hsa-let-7b Breast Neoplasms Expression of SMUG1 and hsa-let-7b-5p were negatively correlated in breast cancer and we found an inhibitory auto-regulatory loop between SMUG1 and hsa-let-7b-5p in the MCF7 breast cancer cells. +other 36155856 hsa-mir-196a-2 Abortion, Septic hominis infection, a significant difference (P < 0.05) was observed in genotypic frequencies of miRNA196a-2 between RPL women and those with one abortion. Estimation of the Odds Ratios indicated that the chance of recurrent abortions in TT genotypes of miRNA196a-2 was about three times more likely than CC in non-infected individuals and about five times more likely than CC in M. +other 36155856 hsa-mir-196a-2 Hodgkin Disease hominis infection, a significant difference (P < 0.05) was observed in genotypic frequencies of miRNA196a-2 between RPL women and those with one abortion. Our results proposed the role of miRNA196a-2 genotypes in RPL either in M. +circulation_biomarker_diagnosis_up 36155776 hsa-mir-515 Pre-Eclampsia 5p may play critical roles in the pathogenesis of preeclampsia through suppression of XIAP, and serum miR +genetics_overexpression_promote 36155610 hsa-mir-10a Pancreatitis Finally, rescue experiments proved that KLF4 overexpression or miR-10a-5p suppression enhanced pyroptosis of AP acinar cells. Overall, USP25 stabilized KLF4 expression through deubiquitination, limited miR-10a-5p expression, and increased GSDMD expression, finally promoting pyroptosis of acinar cells in AP. +exosome 36155593 hsa-mir-193b Seminoma Taken together, these findings indicate that exosomal miR-193b-3p regulates the chemosensitivity of TCam-2 cells to cisplatin through ZBTB7A signaling and could be a promising drug target for patients with chemoresistant seminoma. +circulation_biomarker_diagnosis_up 36155522 hsa-mir-146a Cognitive Dysfunction OBJECTIVE: We examined the expression of circulatory miRNAs with a documented role in AD pathophysiology: miR-29a/b, miR-101, miR-125b, miR-146a, and miR-155 in the plasma of AD patients (AD, n = 12), people with mild cognitive impairment (MCI, n = 9), and normocognitive group (CTRL, n = 18). +genetics_knock down_promote 36155410 hsa-mir-199a Intervertebral Disc Degeneration CDKN1B knockdown partially abrogated the effects of miR-199a-5p inhibition on DNPC proliferation and apoptosis. +circRNA target 36155326 hsa-mir-625 Squamous Cell Carcinoma of Head and Neck 5p/STAT3 axis to activate JAK/STAT3 signaling pathway, consequently facilitating OSCC cell proliferation and inhibiting cell apoptosis. +lncRNA target 36155216 hsa-mir-6499 Liver Cirrhosis CONCLUSION: Sal B suppresses HSC activation and liver fibrosis via regulation of miR3p/LncRNA-ROR-mediated NF-kappaB signaling pathway. +lncRNA target 36155181 hsa-mir-21 Pulmonary Fibrosis Treatment with either NaHS or BM-MSC leads to an inhibitory effect on pulmonary fibrosis as evidenced by improvement of histopathological studies, pulmonary function tests, reduction of inflammatory and fibrotic markers like Hydroxyproline, TNF alpha, TGF-beta and caspase -3 together with downregulation miR-21 and increase lncRNA-GAS5 expression. SIGNIFICANCE: The current work revealed the inhibitory effect of combined NaHS and BM-MSC on pulmonary fibrosis with concomitant modulation of miR-21 and lncRNA-GAS5 expression. +circulation_biomarker_diagnosis_down 36155067 hsa-mir-181c Alzheimer Disease CONCLUSION: This study spots for the first time the diagnostic potential of serum miR-34a, miR-29b and miR-181c as minimally invasive AD biomarker panel in Egyptian patients and highlights their contribution in AD pathogenesis. +circulation_biomarker_diagnosis_down 36155067 hsa-mir-34a Alzheimer Disease CONCLUSION: This study spots for the first time the diagnostic potential of serum miR-34a, miR-29b and miR-181c as minimally invasive AD biomarker panel in Egyptian patients and highlights their contribution in AD pathogenesis. +circulation_biomarker_diagnosis_down 36155067 hsa-mir-29b Alzheimer Disease CONCLUSION: This study spots for the first time the diagnostic potential of serum miR-34a, miR-29b and miR-181c as minimally invasive AD biomarker panel in Egyptian patients and highlights their contribution in AD pathogenesis. +other 36154667 hsa-mir-486 Diabetic Nephropathies 5p-CSF2RB presents a biomarker axis to the occurrence and development of DN. +other 36154667 hsa-mir-155 Diabetic Nephropathies 5p-CSF2RB presents a biomarker axis to the occurrence and development of DN. +other 36154076 hsa-let-7g Liver Neoplasms In an aggressive MYC-driven liver cancer model relevant to hepatocytes, 5A2-SC8 LNPs carrying let-7g miRNA were able to significantly extend survival up to 121 days. +genetics_knock down_promote 36153644 hsa-mir-16 Sepsis Knockdown of miR +genetics_overexpression_promote 36153605 hsa-mir-1286 Osteosarcoma OS cell progression was suppressed by miR-1286 overexpression via downregulating MAFB. +lncRNA target 36153499 hsa-mir-155 Pre-Eclampsia CONCLUSION: LINC00240 inhibited symptoms of preeclampsia through regulation on miR-155/Nrf2 axis, which suppressed oxidative stress-induced pyroptosis to improve trophoblast function and M2 macrophage polarization. +lncRNA target 36153449 hsa-mir-126 Brain Ischemia OBJECTIVE: To observe the effect of electroacupuncture (EA) on miRNA3p and mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1alpha (HIF-1alpha) signaling pathway in rats with cerebral ischemia (CI), so as to explore the underlying mechanism of EA on angiogenesis. +lncRNA target 36153434 hsa-mir-770 Diabetic Nephropathies CONCLUSIONS: These results suggest that circ ASAP2 decreased inflammation and ferroptosis in DN through SOX2/SLC7A11 by miR +other 36153426 hsa-mir-664b Alzheimer Disease Moreover, two miRNAs (miR-3651, miR-664b-3p) showed significant differential expression in AD brains versus controls, in accordance with the change direction of lead exposure. +other 36153426 hsa-mir-651 Alzheimer Disease Moreover, two miRNAs (miR-3651, miR-664b-3p) showed significant differential expression in AD brains versus controls, in accordance with the change direction of lead exposure. +lncRNA target 36153370 hsa-mir-648 Stomach Neoplasms Our studies suggest that miR-3648 acts as a tumour-suppressive miRNA and that the miR-3648/FRAT1-FRAT2/c-Myc negative feedback loop could be a critical regulator of GC progression. +lncRNA target 36153332 hsa-mir-760 Breast Neoplasms We then verified that HM13 was a direct target of miR-760 functioned as a tumor -suppressor in breast cancer. Taken together, these findings elucidated that HM13, targeted by miR-760, could play an oncogenic role in breast cancer by inducing autophagic inhibition and facilitating PI3K-AKT-mTOR pathway. +other 36153316 hsa-mir-216a nonpapillary renal cell carcinoma Furthermore, USP1 and survivin protein expression showed a positive correlation, whereas miR-216a-5p and DR5 were inversely correlated in RCC tumor tissues. +lncRNA target 36153002 hsa-mir-29b Fibrosis, Renal In general, our data show that circRNA_33702 may promote renal fibrosis via the miR-29b-3p/WISP1 axis, which may potentially be developed as a new therapeutic target. +exosome 36152993 hsa-mir-100 Colorectal Neoplasms Collectively, our data indicated that MSC-Exos could suppress proliferation, migration, invasion and metastasis while inducing the apoptosis of the CRC cells via miR-100/mTOR/miR-143 axis. +lncRNA target 36152745 hsa-mir-34c Memory Disorders In conclusion, miR-34c antagomir may be considered as a promising novel therapeutic target for AD patients. +transcription factor target 36151071 hsa-mir-138 Endometrial Neoplasms Further mechanistic studies indicated that miR5p was a tumor suppressor in PSCC by inhibiting the translation of HOXD11 post-transcriptionally through binding to the 3' untranslated region. +transcription factor target 36151071 hsa-mir-138 Penile Neoplasms Further mechanistic studies indicated that miR5p was a tumor suppressor in PSCC by inhibiting the translation of HOXD11 post-transcriptionally through binding to the 3' untranslated region. +transcription factor target 36150742 hsa-mir-495 Huntington Disease 3p, which inhibit Prr7 mRNA translation and are required for HSD. +transcription factor target 36150742 hsa-mir-29 Huntington Disease 3p, which inhibit Prr7 mRNA translation and are required for HSD. +other 36150451 hsa-mir-183 Muscular Atrophy Carnosol at 5 to 20 muM could dose-dependently ameliorate the myotube atrophy induced by miR5p. +lncRNA target 36150451 hsa-mir-183 Cachexia 5p, based on both its inhibiting effects on MuRF-1 and Atrogin +other 36149935 hsa-mir-21 Heart Failure Besides, the levels of miR-21 and -23 were significantly lower in patients with ischemia-induced HF. +other 36149935 hsa-mir-1 Heart Failure 5-p can be taken into account as diagnostic aids for AHF. +other 36149935 hsa-mir-23 Heart Failure Besides, the levels of miR-21 and -23 were significantly lower in patients with ischemia-induced HF. +other 36149758 hsa-mir-326 Pancreatic Carcinoma 3p/TUFT1/AKT-mTOR axis. +lncRNA target 36149748 hsa-mir-135b Rhinitis, Allergic MALAT1 facilitated AR development by facilitating CD4(+) T cell Th2 differentiation via the miR-135b-5p/GATA-3 axis. +lncRNA target 36148952 hsa-mir-140 Fibrosis, Renal Collectively, this study highlights that TUG1 inhibition upregulates miR +lncRNA target 36148952 hsa-mir-140 Hyperuricemia Collectively, this study highlights that TUG1 inhibition upregulates miR +genetics_knock down_promote 36148947 hsa-mir-182 Liver Cirrhosis Knockdown or overexpression of miR +exosome 36148757 hsa-mir-30 Lung Neoplasms All results suggested that exosomal transfer of circSATB2 contributed to the malignant development of lung cancer by acting as a sponge of miR +genetics_knock down_promote 36148577 hsa-mir-149 Colorectal Neoplasms CONCLUSIONS: Circ_0003602 knockdown impedes CRC development by targeting the miR +target gene 36147907 hsa-mir-145 Prostatic Neoplasms microRNA-145-5p inhibits prostate cancer bone metastatic by modulating the epithelial-mesenchymal transition. +other 36147635 hsa-mir-4746 Adenocarcinoma of Lung 5p) could apparently improve the OS rate of patient with LUAD. +other 36147635 hsa-mir-671 Adenocarcinoma of Lung 5p) could apparently improve the OS rate of patient with LUAD. +other 36147635 hsa-mir-126 Adenocarcinoma of Lung 5p) could apparently improve the OS rate of patient with LUAD. +other 36147635 hsa-mir-556 Adenocarcinoma of Lung 5p) could apparently improve the OS rate of patient with LUAD. +other 36147635 hsa-mir-19a Adenocarcinoma of Lung 5p) could apparently improve the OS rate of patient with LUAD. +other 36147635 hsa-mir-4664 Adenocarcinoma of Lung 5p) could apparently improve the OS rate of patient with LUAD. +other 36147635 hsa-mir-937 Adenocarcinoma of Lung 5p) could apparently improve the OS rate of patient with LUAD. +other 36147570 hsa-mir-150 limb ischemia 5p may be sensitive risk markers for predicting endothelial dysfunction in patients with ATH (ATH and SCH+ATH groups). +other 36147570 hsa-mir-21 limb ischemia CONCLUSIONS: miR5p may be involved in the atherosclerosis process in patients with SCH (SCH and SCH+ATH groups). +genetics_knock down_suppress 36147545 hsa-mir-936 Osteosarcoma RESULTS: Increased circDOCK1 and LEF1, and decreased miR-936 were found in OS tissues and cell lines. CONCLUSION: CircDOCK1 knockdown might attenuate OS cell malignant biological behaviors by regulating the miR-936/GFRA1 axis, which may highlight the diagnostic and therapeutic potential of these molecules for OS treatment. +genetics_GWAS 36147476 hsa-mir-34a Colorectal Neoplasms Mir34a-inactivation related expression signatures were associated with CMS4/CRISB+D, stage 4 CRCs and poor patient survival. This study provides genetic evidence for a requirement of Mir34a-mediated Csf1r suppression for intestinal stem/secretory cell homeostasis and tumor suppression, and suggests that therapeutic targeting of CSF1R may be effective for the treatment of CRCs with defects in the p53/miR-34a pathway. +other 36147476 hsa-mir-34a Colorectal Neoplasms, Hereditary Nonpolyposis mRNAs containing Mir34a seed-matching sites, which encode proteins related to EMT (epithelial-mesenchymal transition), stemness and Wnt signaling, were enriched after Mir34a inactivation in adenomas and derived tumoroids. +other 36147476 hsa-mir-34a Adenoma mRNAs containing Mir34a seed-matching sites, which encode proteins related to EMT (epithelial-mesenchymal transition), stemness and Wnt signaling, were enriched after Mir34a inactivation in adenomas and derived tumoroids. +transcription factor target 36147476 hsa-mir-34a Intestinal Neoplasms However, the in vivo relevance of the suppression of CSF1R by miR-34a for intestinal tumor suppression mediated by the p53/miR-34a pathway has remained unknown. +other 36144224 hsa-mir-592 overactive bladder syndrome 5p and miR-592 in urine could be a useful and non-invasive tool for the diagnosis of OAB syndrome in aging women. +lncRNA target 36143385 hsa-mir-155 Bone Pain 5p restored Sgk3-expression-attenuated microglial activation and alleviated hyperalgesia in the BCP rats. +lncRNA target 36143385 hsa-mir-155 Hyperalgesia 5p restored Sgk3-expression-attenuated microglial activation and alleviated hyperalgesia in the BCP rats. +other 36143269 hsa-mir-1290 Sjogren's Syndrome Logistic regression analysis revealed a more significant influence of miR-1290 and let-7b-5p in the SS group than that in the control group. The combination of miR-1290 and let-7b-5p distinguished SS from the control samples with an AUC, sensitivity, specificity, positive predictive value, and negative predictive value of 0.856, 91.7%, 83.3%, 84.6%, and 90.9%, respectively. +other 36143269 hsa-let-7b Sjogren's Syndrome Logistic regression analysis revealed a more significant influence of miR-1290 and let-7b-5p in the SS group than that in the control group. The combination of miR-1290 and let-7b-5p distinguished SS from the control samples with an AUC, sensitivity, specificity, positive predictive value, and negative predictive value of 0.856, 91.7%, 83.3%, 84.6%, and 90.9%, respectively. +other 36143090 hsa-mir-34a Pneumonia RESULTS: Asthmatic patients had a significant lower expression of hsa-miR-34a-5p, 181a-5p and 146a-5p compared to both obese and healthy ones suggesting microRNAs' specific involvement in the regulation of lungs inflammatory response. +other 36142883 hsa-mir-126 Carotid Artery Diseases Down-regulation of miR5p expression has been identified as a promising biomarker of advanced carotid atherosclerosis with high specificity and sensitivity. +other 36142883 hsa-mir-33a Carotid Artery Diseases 5p with ADAMTS13, erythrocyte sedimentation rate and D-dimer (r = 0.42, r = 0.36 and r = 0.44, respectively, p < 0.05); stenosis degree with miR-33a-5p/3p and factor VIII levels (r = 0.43 (both) and r = 0.62, respectively, p < 0.05). +other 36142712 hsa-mir-29a Testicular Diseases album and two of its isolated compounds, rutin and the new saponin zygo-albuside A, against methotrexate (MTX)-induced testicular injury, considering the role of miRNA-29a. The mRNA expression levels of nuclear factor-kappa B (NF-kappaB), tumor necrosis factor-alpha (TNF-alpha), p53, and miRNA-29a were downregulated in the testicular tissues of the protected groups compared with the unprotected group. +other 36142686 hsa-mir-1290 Enzootic Bovine Leukosis bta-miR-1246 and hsa-miR5p, but not hsa-miR-1290, were detected using qPCR and their levels in milk sEVs from EBL cattle were significantly higher than those in BLV-uninfected cattle. +transcription factor target 36142686 hsa-mir-424 Enzootic Bovine Leukosis 5p in sEVs may promote metastasis by targeting tumor suppressor genes, resulting in increased amounts in milk sEVs in EBL cattle. +other 36142646 hsa-mir-29a Scleroderma, Systemic All of the rest of the analyzed microRNAs, excluding miR-126, miR-29a and miR-181a, were significantly upregulated in SSc patients in comparison to HC. +other 36142646 hsa-mir-132 Scleroderma, Systemic Additionally, the expression of miR-132 was significantly higher in dcSSc subgroup with detected active lung lesions compared to dcSSc patients with fibrotic lesions. +circulation_biomarker_diagnosis_ns 36142646 hsa-mir-181a Scleroderma, Systemic However, miR-181a has been revealed only in the serum of patients with lcSSc but not dcSSc. +other 36142646 hsa-mir-126 Scleroderma, Systemic All of the rest of the analyzed microRNAs, excluding miR-126, miR-29a and miR-181a, were significantly upregulated in SSc patients in comparison to HC. +other 36142607 hsa-mir-494 Squamous Cell Carcinoma of Head and Neck Using the human OSCC cell lines HSC3 and HSC4, we demonstrate that HOXA11-AS promotes NQO1 expression by sponging microRNA-494. +exosome 36142562 hsa-mir-484 Hodgkin Disease Finally, microRNA analysis in HL-60 and HL-60/ADR cells and exosomes showed that miR-484 elevation in HL-60/ADR cells and exosomes was associated with exosome-mediated cell proliferation. +genetics_GWAS 36142557 hsa-let-7a-1 Leprosy The rs10739971 (pri-let-7a1) polymorphism was associated with the development of leprosy, while rs2910164 (miR146A) and rs10035440 (DROSHA) was significantly associated with an increased risk of developing multibacillary leprosy. +genetics_GWAS 36142557 hsa-mir-4513 Leprosy In contrast, the SNPs rs10739971 (pri-let-7a1), rs12904 (miR200C), and rs2168518 (miR4513) are associated with the development of the paucibacillary leprosy. +genetics_GWAS 36142557 hsa-mir-200c Leprosy In contrast, the SNPs rs10739971 (pri-let-7a1), rs12904 (miR200C), and rs2168518 (miR4513) are associated with the development of the paucibacillary leprosy. +genetics_GWAS 36142557 hsa-mir-146a Leprosy The rs10739971 (pri-let-7a1) polymorphism was associated with the development of leprosy, while rs2910164 (miR146A) and rs10035440 (DROSHA) was significantly associated with an increased risk of developing multibacillary leprosy. +exosome 36142544 hsa-mir-1307 Squamous Cell Carcinoma of Head and Neck Conclusions: Salivary exosomal miRNA5p is a potential prognosticator for predicting poor survival and poor patient outcome in oral cancers. +other 36142536 hsa-mir-20b Diabetes, Gestational 3p). +other 36142536 hsa-mir-20b Abortion 3p). +other 36142536 hsa-mir-20b Cardiovascular Diseases 3p). +other 36142536 hsa-mir-195 Diabetes, Gestational 3p). +other 36142536 hsa-mir-20a Cardiovascular Diseases 3p). +other 36142536 hsa-mir-195 Abortion 3p). +other 36142536 hsa-mir-20a Diabetes, Gestational 3p). +other 36142536 hsa-mir-195 Cardiovascular Diseases 3p). +other 36142536 hsa-mir-20a Abortion 3p). +genetics_overexpression_promote 36142477 hsa-mir-3687 Prostatic Neoplasms PCa and CRPC cell lines were transfected with miR-3687 or miR-4417 to overexpress the miRNAs. +genetics_overexpression_promote 36142477 hsa-mir-4417 Prostatic Neoplasms PCa and CRPC cell lines were transfected with miR-3687 or miR-4417 to overexpress the miRNAs. +other 36142465 hsa-mir-29-2 Plaque, Amyloid 5p expression in the frontal cortex region. +other 36142465 hsa-mir-29b-2 Plaque, Amyloid 5p expression in the frontal cortex region. +other 36142307 hsa-mir-486 Hypertension, Pulmonary 5p during PAH development. +lncRNA target 36142220 hsa-mir-93 Periodontitis The objective of the present study was to explore hypoxia-related miRNA target genes for HIF-1alpha and NFAT5, as well as miRNA-20a, miRNA-30e, and miRNA-93 expression in periodontitis versus healthy gingival tissues and gingival mesenchymal stem cells (GMSCs) cultured under hypoxic conditions. +lncRNA target 36142220 hsa-mir-20a Periodontitis The objective of the present study was to explore hypoxia-related miRNA target genes for HIF-1alpha and NFAT5, as well as miRNA-20a, miRNA-30e, and miRNA-93 expression in periodontitis versus healthy gingival tissues and gingival mesenchymal stem cells (GMSCs) cultured under hypoxic conditions. +other 36142200 hsa-mir-194 Zika Virus Infection We observed downregulation of miR-302b, miR-302c and miR-194, whereas miR-30c was upregulated in ZIKV infected human NPCs in vitro. +genetics_overexpression_suppress 36142173 hsa-mir-155 Plaque, Atherosclerotic 3p overexpression decreased IGF-IIR reducing apoptosis in vascular cells; (4) Conclusions: Our results suggest that miR +genetics_overexpression_suppress 36142173 hsa-mir-143 Plaque, Atherosclerotic 3p overexpression decreased IGF-IIR reducing apoptosis in vascular cells; (4) Conclusions: Our results suggest that miR +transcription factor target 36142146 hsa-mir-142 Stroke Taken together, our results indicate that miR-142 targets TIM-1, representing a novel strategy against cerebrovascular disorders, as well as systemic complications of SARS-CoV-2 and other viral infections. +transcription factor target 36142146 hsa-mir-142 COVID-19 Taken together, our results indicate that miR-142 targets TIM-1, representing a novel strategy against cerebrovascular disorders, as well as systemic complications of SARS-CoV-2 and other viral infections. +transcription factor target 36142146 hsa-mir-142 Zika Virus Infection Taken together, our results indicate that miR-142 targets TIM-1, representing a novel strategy against cerebrovascular disorders, as well as systemic complications of SARS-CoV-2 and other viral infections. +transcription factor target 36142146 hsa-mir-142 Hemorrhagic Fever, Ebola Taken together, our results indicate that miR-142 targets TIM-1, representing a novel strategy against cerebrovascular disorders, as well as systemic complications of SARS-CoV-2 and other viral infections. +transcription factor target 36142146 hsa-mir-142 Dengue Taken together, our results indicate that miR-142 targets TIM-1, representing a novel strategy against cerebrovascular disorders, as well as systemic complications of SARS-CoV-2 and other viral infections. +transcription factor target 36142146 hsa-mir-142 Infections Taken together, our results indicate that miR-142 targets TIM-1, representing a novel strategy against cerebrovascular disorders, as well as systemic complications of SARS-CoV-2 and other viral infections. +other 36140836 hsa-mir-122 Carcinoma, Hepatocellular miR-122 was highly expressed in HCV patients with a significant difference from the HCC group (p = 0.004), which points towards its role in prognosis value as a predictor of HCC in patients with chronic HCV. +lncRNA target 36140796 hsa-mir-138 Urinary Bladder Neoplasms 5P, and their target genes can be developed as accurate biomarkers for prognosis in bladder cancer with a muscular invasion. +lncRNA target 36140796 hsa-mir-124 Urinary Bladder Neoplasms 5P, and their target genes can be developed as accurate biomarkers for prognosis in bladder cancer with a muscular invasion. +lncRNA target 36140796 hsa-let-7a Urinary Bladder Neoplasms 5P, and their target genes can be developed as accurate biomarkers for prognosis in bladder cancer with a muscular invasion. +other 36140779 hsa-mir-205 Endometrial Neoplasms Paired samples of tumor-adjacent tissues and primary tumors from 49 patients with endometrial cancer (EC), samples of endometrium from 25 patients with leiomyomas of the uterus, and 4 endometrial cancer cell lines were examined by the RT-qPCR, for MYC, NR5A2, CXCR2, HMGA2, LIN28A, OCT4A, OCT4B, OCT4B1, TWIST1, STK11, SNAI1, and miR5p expression. +lncRNA target 36140281 hsa-mir-499 Cardiomyopathy, Hypertrophic target genes, SOX6 and PTBP3, were upregulated in HCM. +other 36140249 hsa-mir-200b Colorectal Neoplasms We found upregulation of miR-200b and ONECUT2 in CRC pT3 and pT4a compared to normal mucosa, and downregulation of CDKN1B in CRC pT3. Moreover, we observed, downregulation of miR-200b, PTPN13 and ZEB2 in CRC with serosal invasion (pT4a) compared to pT3. +lncRNA target 36140236 hsa-mir-18a Cardiovascular Diseases We confirmed the pro-atherogenic effect of miR-18a-5p in subclinical CVD and identified several target genes for future CVD therapies. +lncRNA target 36140165 hsa-mir-93 Endometriosis Three miRNAs, let-7b and miR-92a-3p, and miR5p potentially targeted KIAA1324, an estrogen-responsive gene and one of the most downregulated genes in OMA. +circulation_biomarker_diagnosis_ns 36139786 hsa-mir-122 Reperfusion Injury, Renal Ischemia 5p expression, pNF-kappaB expression, Bax/caspase 3/poly(ADP-ribose) polymerase (PARP)-mediated apoptosis, blood urea nitrogen, and creatinine levels. +other 36139749 hsa-mir-21 Vascular Diseases Moreover, c-miR-21 and c-miR-126, along with GPx and AOPP levels, should be considered possible markers for VC development in future studies. +other 36139749 hsa-mir-126 Vascular Diseases Moreover, c-miR-21 and c-miR-126, along with GPx and AOPP levels, should be considered possible markers for VC development in future studies. +other 36139749 hsa-mir-126 Diabetes Mellitus, Type 2 Moreover, c-miR-21 and c-miR-126, along with GPx and AOPP levels, should be considered possible markers for VC development in future studies. +other 36139749 hsa-mir-21 Diabetes Mellitus, Type 2 Moreover, c-miR-21 and c-miR-126, along with GPx and AOPP levels, should be considered possible markers for VC development in future studies. +genetics_overexpression_promote 36139455 hsa-mir-155 Cholangitis, Biliary, Primary RESULTS: A reduction of PPARalpha in primary biliary cholangitis (PBC) livers was associated with miR-21 and miR-155 upregulation. CONCLUSIONS: Hepatic PPARalpha expression is reduced in PBC livers as a likely result of miR-155 overexpression. +other 36139455 hsa-mir-21 Cholangitis, Biliary, Primary RESULTS: A reduction of PPARalpha in primary biliary cholangitis (PBC) livers was associated with miR-21 and miR-155 upregulation. +genetics_overexpression_promote 36139435 hsa-mir-22 Carcinoma, Hepatocellular MiR-22 is mostly considered as a hepatic tumor-suppressor microRNA based on in vitro analyses. Our study demonstrates that miR-22 acts as a hepatic tumor suppressor in vivo by restraining pro-carcinogenic metabolic deregulations through pleiotropic mechanisms and the overexpression of relevant oncogenes. +genetics_overexpression_promote 36139435 hsa-mir-22 Fatty Liver MiR-22 is mostly considered as a hepatic tumor-suppressor microRNA based on in vitro analyses. Our study demonstrates that miR-22 acts as a hepatic tumor suppressor in vivo by restraining pro-carcinogenic metabolic deregulations through pleiotropic mechanisms and the overexpression of relevant oncogenes. +other 36139316 hsa-mir-188 Opitz GBBB Syndrome, X-Linked At the same time, miR5p expression in Exo-OS was significantly higher than in Exo-MS (p < 0.01), implying that it may play an important role in regulating the lifespan and reproductive potential of sows. +other 36139316 hsa-mir-188 Multiple Sclerosis At the same time, miR5p expression in Exo-OS was significantly higher than in Exo-MS (p < 0.01), implying that it may play an important role in regulating the lifespan and reproductive potential of sows. +circulation_biomarker_diagnosis_ns 36139082 hsa-mir-223 Myocardial Infarction Conclusions-Circulating miR-223 and miR-186 are promising predictive biomarkers for long-term mortality after MI. +circulation_biomarker_diagnosis_ns 36139082 hsa-mir-186 Myocardial Infarction Conclusions-Circulating miR-223 and miR-186 are promising predictive biomarkers for long-term mortality after MI. +circulation_biomarker_diagnosis_ns 36139032 hsa-mir-29a Fetal Growth Retardation Co-expression network analysis of umbilical cord blood and skeletal muscle miRNAs showed that the miR-29 family is an essential regulator of IUGR pigs. Transfection of IUGR pig umbilical cord blood exosomes and miR-29a mimic significantly inhibited cell proliferation and promoted the expression of cellular protein degradation marker genes Fbxo32 and Trim63. +circulation_biomarker_diagnosis_ns 36139032 hsa-mir-29 Skeletal Muscle Dysplasia Co-expression network analysis of umbilical cord blood and skeletal muscle miRNAs showed that the miR-29 family is an essential regulator of IUGR pigs. Transfection of IUGR pig umbilical cord blood exosomes and miR-29a mimic significantly inhibited cell proliferation and promoted the expression of cellular protein degradation marker genes Fbxo32 and Trim63. +circulation_biomarker_diagnosis_ns 36139032 hsa-mir-29a Skeletal Muscle Dysplasia Co-expression network analysis of umbilical cord blood and skeletal muscle miRNAs showed that the miR-29 family is an essential regulator of IUGR pigs. Transfection of IUGR pig umbilical cord blood exosomes and miR-29a mimic significantly inhibited cell proliferation and promoted the expression of cellular protein degradation marker genes Fbxo32 and Trim63. +circulation_biomarker_diagnosis_ns 36139032 hsa-mir-29 Fetal Growth Retardation Co-expression network analysis of umbilical cord blood and skeletal muscle miRNAs showed that the miR-29 family is an essential regulator of IUGR pigs. Transfection of IUGR pig umbilical cord blood exosomes and miR-29a mimic significantly inhibited cell proliferation and promoted the expression of cellular protein degradation marker genes Fbxo32 and Trim63. +other 36138893 hsa-mir-223 Brain Injuries MiR-223 is a miRNA with important functions in apoptosis, carcinogenesis, and inflammation, and it was demonstrated to be over-expressed in brain tissue after traumatic brain injury (TBI). Moreover, miR-223 may play a role in maintaining the integrity of BBB during TBI. +circulation_biomarker_diagnosis_ns 36138476 hsa-mir-486 Hemolysis RESULTS: The abundance of miR-16, miR-92a, miR-191, miR-451 and miR-486 was significantly sensitive to haemolysis in serum and serum-derived EVs, while other selected miRNAs were not influenced by haemolysis. +circulation_biomarker_diagnosis_ns 36138476 hsa-mir-451 Hemolysis RESULTS: The abundance of miR-16, miR-92a, miR-191, miR-451 and miR-486 was significantly sensitive to haemolysis in serum and serum-derived EVs, while other selected miRNAs were not influenced by haemolysis. +circulation_biomarker_diagnosis_ns 36138476 hsa-mir-16 Hemolysis RESULTS: The abundance of miR-16, miR-92a, miR-191, miR-451 and miR-486 was significantly sensitive to haemolysis in serum and serum-derived EVs, while other selected miRNAs were not influenced by haemolysis. +circulation_biomarker_diagnosis_ns 36138476 hsa-mir-191 Hemolysis RESULTS: The abundance of miR-16, miR-92a, miR-191, miR-451 and miR-486 was significantly sensitive to haemolysis in serum and serum-derived EVs, while other selected miRNAs were not influenced by haemolysis. +circulation_biomarker_diagnosis_ns 36138476 hsa-mir-92a Hemolysis RESULTS: The abundance of miR-16, miR-92a, miR-191, miR-451 and miR-486 was significantly sensitive to haemolysis in serum and serum-derived EVs, while other selected miRNAs were not influenced by haemolysis. +genetics_overexpression_suppress 36138468 hsa-mir-99a Pulmonary Fibrosis Therefore, overexpression of MIR99AHG may provide a new approach to preventing LUAD progression. +circulation_biomarker_diagnosis_ns 36138395 hsa-mir-576 Atherosclerosis 3p/IFIT1/STAT1 feedback loop participates in atherosclerosis progression and contributes to the high circ_0086296 expression observed in the exosomes of serum of patients with atherosclerosis. +genetics_overexpression_promote 36138344 hsa-mir-27b Carcinoma, Hepatocellular Recombinant oncolytic adenovirus (Onco(Ad)) overexpressing hsa-miR-27b was constructed to detect their therapeutic value in HCC. +genetics_overexpression_promote 36138295 hsa-mir-34b Liver Cirrhosis Conclusively, overexpressing miR-34b-5p reduced TGF-beta-induced HSC activation by inhibiting EZH2 and thereby promoting MFGE8 expression, and inhibited liver fibrosis in vivo through the EZH2/MFGE8 axis. +transcription factor target 36137407 hsa-mir-21 Mental Disorders Notably, a set of dysregulated miRNA signatures including hsa-mia-451a and hsa-mir-21a resulted in an AUC of 0.966 and 0.861, respectively, for predicting the patients with SUDs. +other 36137399 hsa-mir-26b Salivary Gland Neoplasms Also, miR-26b was selectively increased in pleomorphic adenomas of the salivary gland. +other 36137399 hsa-mir-200a Salivary Gland Neoplasms Remarkably, we found that miR-200a and miR-373 were significantly upregulated whereas miR-30c were downregulated in tissues of patients with salivary gland tumors, compared to adjacent healthy tissue samples. +other 36137399 hsa-mir-145 Salivary Gland Neoplasms Additionally, miR-145 and miR-30a were found to be specifically downregulated in a mucoepidermoid carcinoma. +other 36137399 hsa-mir-373 Salivary Gland Neoplasms Remarkably, we found that miR-200a and miR-373 were significantly upregulated whereas miR-30c were downregulated in tissues of patients with salivary gland tumors, compared to adjacent healthy tissue samples. +lncRNA target 36136991 hsa-mir-16 Breast Neoplasms 5p/UBE2C axis might be a prospective therapeutic target in the BC treatment by sponging miR +circRNA target 36136989 hsa-mir-185 Multiple Myeloma Circ_0005615 contributed to the malignant progression and bortezomib resistance of multiple myeloma through mediating miR +genetics_knock down_suppress 36136988 hsa-mir-1271 Endometrial Neoplasms 5p, and its overexpression eliminated the promotion effect of miR +genetics_knock down_suppress 36136987 hsa-mir-136 Prostatic Neoplasms 5p inhibitor or TRIB1 overexpression. +transcription factor target 36136972 hsa-mir-206 Breast Neoplasms Our results showed that miR-206 mimics suppressed CALR expression, inhibited the proliferation and metastasis ability of breast cancer stem cells and finally induced cellular apoptosis. +circulation_biomarker_diagnosis_ns 36136693 hsa-mir-192 Polyps Novel biomarkers such as miRNA-20b and miRNA-192 might have diagnostic potential in feline intestinal neoplasms and should be further investigated. +circulation_biomarker_diagnosis_ns 36136693 hsa-mir-192 Gastrointestinal Neoplasms Novel biomarkers such as miRNA-20b and miRNA-192 might have diagnostic potential in feline intestinal neoplasms and should be further investigated. +circulation_biomarker_diagnosis_ns 36136693 hsa-mir-20b Gastrointestinal Neoplasms Novel biomarkers such as miRNA-20b and miRNA-192 might have diagnostic potential in feline intestinal neoplasms and should be further investigated. +circulation_biomarker_diagnosis_ns 36136693 hsa-mir-20b Polyps Novel biomarkers such as miRNA-20b and miRNA-192 might have diagnostic potential in feline intestinal neoplasms and should be further investigated. +transcription factor target 36136257 hsa-mir-17 Melanoma Taken together, our results suggest that quercetin can regulate cell proliferation and apoptosis through TET1 via miR-17 in melanoma cells. +other 36135175 hsa-mir-942 Stomach Neoplasms In conclusion, this study demonstrated that hsa-miR3p could be a potential prognostic marker of gastric cancer associated with the AR and MAPK/ERK signaling pathways. +genetics_overexpression_promote 36135094 hsa-mir-1287 Leukemia, Myeloid, Acute 5p expression was down-regulated in AML patients and up-regulated in circ_0059707-overexpressing cells. +lncRNA target 36134741 hsa-mir-520h Stomach Neoplasms Furthermore, CDC42 was a functional target of miR-520h in regulating GC cell behaviors. +exosome 36133788 hsa-mir-34c Constipation BACKGROUND: The pathogenesis of slow transit constipation (STC) is associated with exosomal miR-34c-5p. CONCLUSION: Our results indicated that EA improves intestinal motility in STC rats by transporting of exosomal miR-34c-5p targeting the SCF/c-Kit signaling pathway. +lncRNA target 36133483 hsa-mir-24 Myocardial Infarction, Acute MicroRNA-24 (miR-24) is an apoptosis suppressor miRNA downregulated in cardiomyocytes after acute myocardial infarction (AMI). However, due to the lack of effective delivery strategies, the role of anti-apoptotic miR-24 in cardiomyocytes post-acute myocardial infarction remains unexplored. +lncRNA target 36132985 hsa-mir-34a Spinal Cord Injuries Notably, in the post-SCI rat model, exogenous miR-34a-3p agomir obviously inhibited the expression of PDCD6 at the protein level and promoted neuronal proliferation, motoneurons regeneration, and axonal myelination. Conclusively, this paper argues that a miR-34a-3p/PDCD6 axis might be a candidate therapeutic target for treating SCI and that the therapeutic effect of EA is driven through this pathway. +lncRNA target 36131212 hsa-mir-124 Microvascular Obstruction Collectively, PPG alleviates ischemia-induced neuronal damage and microglial inflammation by modulating the miR3p/TRAF6/NF-kappaB pathway. +epigenetics 36130949 hsa-mir-663 Obesity, Maternal Brain and cffDNA methylation levels from a large region overlapping mir-663 correlated with maternal obesity, metabolic and immune markers, and infant behavior. +exosome 36129637 hsa-mir-140 Subarachnoid Hemorrhage Collectively, our findings indicated that ADSC-Exos-miR +lncRNA target 36129629 hsa-let-7a Developmental Disabilities In addition, the suppression of let-7a-5p and let-7g-5p might be associated with the occurrence of development arrest. +lncRNA target 36129629 hsa-let-7a Heart Arrest In addition, the suppression of let-7a-5p and let-7g-5p might be associated with the occurrence of development arrest. +lncRNA target 36129629 hsa-let-7g Developmental Disabilities In addition, the suppression of let-7a-5p and let-7g-5p might be associated with the occurrence of development arrest. +lncRNA target 36129629 hsa-let-7g Heart Arrest In addition, the suppression of let-7a-5p and let-7g-5p might be associated with the occurrence of development arrest. +lncRNA target 36129595 hsa-mir-486 Myocardial Infarction 5p and upregulation of XIST inhibited hypoxic injury by downregulating miR +lncRNA target 36129595 hsa-mir-4486 Myocardial Infarction 5p and upregulation of XIST inhibited hypoxic injury by downregulating miR +other 36129161 hsa-mir-22 Mitochondrial Diseases Treatment of PC12 cells with STZ resulted in mitochondrial dysfunction and increased autophagic markers, including LC3-II, Beclin1, Akt, ATG genes, and accumulation of miR-21 and miR-22. +other 36129161 hsa-mir-21 Mitochondrial Diseases Treatment of PC12 cells with STZ resulted in mitochondrial dysfunction and increased autophagic markers, including LC3-II, Beclin1, Akt, ATG genes, and accumulation of miR-21 and miR-22. +circulation_biomarker_diagnosis_down 36128917 hsa-mir-181b Cerebral Hemorrhage Further studies on the plasma lncRNA-MEG3, miR-181b, and UCH-L1 levels in patients with ICH could yield novel biological targets for the prediction and treatment of ICH. +transcription factor target 36128801 hsa-mir-1275 Obesity, Abdominal Thus, miR-1275 might be a potential target in the management of visceral obesity and related metabolic diseases. +transcription factor target 36128801 hsa-mir-1275 Obesity Thus, miR-1275 might be a potential target in the management of visceral obesity and related metabolic diseases. +transcription factor target 36128801 hsa-mir-1275 Metabolic Diseases Thus, miR-1275 might be a potential target in the management of visceral obesity and related metabolic diseases. +lncRNA target 36128198 hsa-mir-378 Pulmonary Disease, Chronic Obstructive miR-378 increased in COPD lung tissues while NPNT decreased, and might prove a potential target for novel drug therapy. +genetics_overexpression_suppress 36128051 hsa-mir-524 Prostatic Neoplasms The overexpression of miR +genetics_overexpression_suppress 36128051 hsa-mir-524 Breast Neoplasms The overexpression of miR +genetics_overexpression_promote 36127685 hsa-mir-99a Osteoarthritis, Spine At the molecular level, miR-99a overexpression downregulated the levels of MMP13, beta-catenin, Bax, and caspase-3 protein expression and upregulated the levels of COL2A1 and Bcl-2 protein expression in the in vitro OA-like chondrocyte model and also in the experimental OA model rats. +lncRNA target 36127622 hsa-mir-193a Triple Negative Breast Neoplasms Additionally, LINC01224 stabilized NUP210 mRNA through interaction with miR-193a-5p, thereby aggravating the malignant phenotypes of TNBC. +genetics_overexpression_promote 36126797 hsa-mir-345 Liver Cirrhosis Furthermore, overexpression of miR +genetics_overexpression_promote 36126276 hsa-mir-151 Head and Neck Neoplasms 3p was the only overexpressed miRNA in validation sample of patients with HNC with early stage at diagnosis (FC = 1.81, P = 0.008) and it was confirmed upregulated both in smoker early-stage cases (FC = 3.52, P = 0.024) and in nonsmoker early-stage cases (FC = 1.60, P = 0.025) compared with controls. +other 36126189 hsa-mir-450b Reperfusion Injury, Renal Ischemia Furthermore, the expression levels of Nrf2 and it-dependent antioxidant enzymes were apparently increased in ischemic kidney after the transfection of miR-450b-5p mimic+recombination protein Nrf2, as well as the decreased expression levels of intracellular ROS and iNOS. +transcription factor target 36125462 hsa-mir-33a Triple Negative Breast Neoplasms RESULTS: We found the vaspin level was positively correlated with BMI in breast malignant patients and vaspin could significantly enhance the proliferation, infiltration and transferring of triple-negative breast cancer cells by restraining the expression of miR-33a-5p. CONCLUSION: Vaspin, as a cancer-promoting cytokine, may inhibit miR-33a-5p thus increasing the level of ABHD2 to promote the development of the triple-negative breast cancer. +circulation_biomarker_diagnosis_ns 36125433 hsa-mir-21 Carcinoma, Renal Cell Treating human umbilical vein endothelial cells (HUVEC) with the plasma of patients with hypertensive ccRCC and miR5p, elevated in the plasma of patients with hypertensive ccRCC, reduced the expression of TIMP3 compared with normotensive and control littermates. +circulation_biomarker_diagnosis_ns 36125433 hsa-mir-21 Hypertension Treating human umbilical vein endothelial cells (HUVEC) with the plasma of patients with hypertensive ccRCC and miR5p, elevated in the plasma of patients with hypertensive ccRCC, reduced the expression of TIMP3 compared with normotensive and control littermates. +genetics_knock down_promote 36125241 hsa-mir-7 Prostatic Neoplasms 5p mimics or inhibitor and/or overexpression vector (EGFR) or small interfering RNA of EGFR (si-EGFR) or its control, and found that overexpression of RHPN1-AS1 inhibited miR +other 36125106 hsa-mir-155 Liver Neoplasms MicroRNA-155 is highly expressed in tumor cells such as lung cancer, liver cancer and lymphoma. +other 36125106 hsa-mir-155 Lung Neoplasms MicroRNA-155 is highly expressed in tumor cells such as lung cancer, liver cancer and lymphoma. +other 36125106 hsa-mir-155 Lymphoma MicroRNA-155 is highly expressed in tumor cells such as lung cancer, liver cancer and lymphoma. +other 36125080 hsa-mir-200c Craniofacial Abnormalities Conclusion: CaCO(3) nanoparticles enhance miR-200c delivery to accelerate alveolar bone formation, thereby demonstrating the application of CaCO(3)/miR-200c to craniofacial bone defects. +circulation_biomarker_diagnosis_ns 36125080 hsa-mir-200c Alveolar Bone Loss This work aimed to enhance transfection efficiency and miR-200c-induced bone formation in alveolar bone defects via plasmid DNA encoding miR-200c delivery from CaCO(3) nanoparticles. CaCO(3)/miR-200c treatment in vivo significantly increased bone formation in rat alveolar bone defects. +circRNA target 36125054 hsa-mir-944 Carcinoma, Hepatocellular Additionally, miR-944 was proved to directly target MAD2L1 in HCC cells. +other 36125044 hsa-mir-1a Cardiomegaly Previous studies have found microRNA-1 (miR-1) and hyperpolarization-activated cyclic nucleotide-gated channel 2 (HCN2) may be involved in the pathogenesis of thyroid hormone (TH) induced cardiac hypertrophy. +other 36125044 hsa-mir-1 Cardiomegaly Previous studies have found microRNA-1 (miR-1) and hyperpolarization-activated cyclic nucleotide-gated channel 2 (HCN2) may be involved in the pathogenesis of thyroid hormone (TH) induced cardiac hypertrophy. +exosome 36123601 hsa-mir-1 Pre-Eclampsia CONCLUSION: We believe that exosome-derived miR +lncRNA target 36123344 hsa-mir-940 Breast Neoplasms 3p/KLLN axis, and suggest that SEAS1 may serve as a potential biomarker and therapeutic target for TNBC. +lncRNA target 36122770 hsa-mir-362 Neuralgia Overall, Miat upregulated BAMBI by inhibiting miR3p, thereby promoting the occurrence and development of NP. +circulation_biomarker_diagnosis_ns 36122657 hsa-mir-4726 Coronary Disease 5p on blood pressure. +lncRNA target 36121635 hsa-mir-188 Cholangiocarcinoma 5p to up-regulate mRNA translation and protein expression of PSMD10, thereby facilitating cholangiocarcinoma cell invasion and migration and inhibiting its apoptosis. +lncRNA target 36121621 hsa-mir-29 Cardiomyopathies Greater profibrotic signaling (miRs-92a, 130, 27, 29) and sodium and calcium channel dysregulation (let-7) were seen in those paced > 10 years with the most dyregulation seen in a patient with sudden death vs. those paced < 10 years. +lncRNA target 36121621 hsa-let-7 Cardiomyopathies Greater profibrotic signaling (miRs-92a, 130, 27, 29) and sodium and calcium channel dysregulation (let-7) were seen in those paced > 10 years with the most dyregulation seen in a patient with sudden death vs. those paced < 10 years. +lncRNA target 36121621 hsa-mir-92a Cardiomyopathies Greater profibrotic signaling (miRs-92a, 130, 27, 29) and sodium and calcium channel dysregulation (let-7) were seen in those paced > 10 years with the most dyregulation seen in a patient with sudden death vs. those paced < 10 years. +lncRNA target 36121621 hsa-mir-27 Cardiomyopathies Greater profibrotic signaling (miRs-92a, 130, 27, 29) and sodium and calcium channel dysregulation (let-7) were seen in those paced > 10 years with the most dyregulation seen in a patient with sudden death vs. those paced < 10 years. +lncRNA target 36121621 hsa-mir-130 Cardiomyopathies Greater profibrotic signaling (miRs-92a, 130, 27, 29) and sodium and calcium channel dysregulation (let-7) were seen in those paced > 10 years with the most dyregulation seen in a patient with sudden death vs. those paced < 10 years. +circulation_biomarker_diagnosis_up 36121133 hsa-mir-155 Breast Neoplasms Studies have consistently noted an increase in miR155 levels in serum and/or tissues in patients with BrCa. +circulation_biomarker_diagnosis_ns 36121076 hsa-mir-29c Nasopharyngeal Carcinoma Furthermore, the validation of hsa-miR-29c-3p expression on plasma NPC with known tumor vs. +transcription factor target 36121042 hsa-mir-144 Endometrial Hyperplasia Taken together, these evidences suggested that miR-144 may act as a promising therapeutic target for arterial restenosis. +circulation_biomarker_diagnosis_ns 36120988 hsa-mir-652 Inflammatory Bowel Diseases RESULTS: The best diagnostic performance for distinguishing GIC from CIE was fecal miR-451 (AUC: 0.955, sensitivity: 86.4%, specificity: 100%), miR-223 (AUC: 0.918, sensitivity: 90.9%, specificity: 80%), and miR-27a (AUC: 0.868, sensitivity: 81.8%, specificity: 90%) and serum miR-20b (AUC: 0.905, sensitivity: 90.5%, specificity: 90%), miR-148a-3p (AUC: 0.924, sensitivity: 85.7%, specificity: 90%), and miR-652 (AUC: 0.943, sensitivity: 90.5%, specificity: 90%). +circulation_biomarker_diagnosis_ns 36120988 hsa-mir-652 Gastrointestinal Neoplasms RESULTS: The best diagnostic performance for distinguishing GIC from CIE was fecal miR-451 (AUC: 0.955, sensitivity: 86.4%, specificity: 100%), miR-223 (AUC: 0.918, sensitivity: 90.9%, specificity: 80%), and miR-27a (AUC: 0.868, sensitivity: 81.8%, specificity: 90%) and serum miR-20b (AUC: 0.905, sensitivity: 90.5%, specificity: 90%), miR-148a-3p (AUC: 0.924, sensitivity: 85.7%, specificity: 90%), and miR-652 (AUC: 0.943, sensitivity: 90.5%, specificity: 90%). +circulation_biomarker_diagnosis_ns 36120988 hsa-mir-27a Gastrointestinal Neoplasms RESULTS: The best diagnostic performance for distinguishing GIC from CIE was fecal miR-451 (AUC: 0.955, sensitivity: 86.4%, specificity: 100%), miR-223 (AUC: 0.918, sensitivity: 90.9%, specificity: 80%), and miR-27a (AUC: 0.868, sensitivity: 81.8%, specificity: 90%) and serum miR-20b (AUC: 0.905, sensitivity: 90.5%, specificity: 90%), miR-148a-3p (AUC: 0.924, sensitivity: 85.7%, specificity: 90%), and miR-652 (AUC: 0.943, sensitivity: 90.5%, specificity: 90%). +circulation_biomarker_diagnosis_ns 36120988 hsa-mir-27a Inflammatory Bowel Diseases RESULTS: The best diagnostic performance for distinguishing GIC from CIE was fecal miR-451 (AUC: 0.955, sensitivity: 86.4%, specificity: 100%), miR-223 (AUC: 0.918, sensitivity: 90.9%, specificity: 80%), and miR-27a (AUC: 0.868, sensitivity: 81.8%, specificity: 90%) and serum miR-20b (AUC: 0.905, sensitivity: 90.5%, specificity: 90%), miR-148a-3p (AUC: 0.924, sensitivity: 85.7%, specificity: 90%), and miR-652 (AUC: 0.943, sensitivity: 90.5%, specificity: 90%). +circulation_biomarker_diagnosis_ns 36120988 hsa-mir-223 Inflammatory Bowel Diseases RESULTS: The best diagnostic performance for distinguishing GIC from CIE was fecal miR-451 (AUC: 0.955, sensitivity: 86.4%, specificity: 100%), miR-223 (AUC: 0.918, sensitivity: 90.9%, specificity: 80%), and miR-27a (AUC: 0.868, sensitivity: 81.8%, specificity: 90%) and serum miR-20b (AUC: 0.905, sensitivity: 90.5%, specificity: 90%), miR-148a-3p (AUC: 0.924, sensitivity: 85.7%, specificity: 90%), and miR-652 (AUC: 0.943, sensitivity: 90.5%, specificity: 90%). +circulation_biomarker_diagnosis_ns 36120988 hsa-mir-20b Gastrointestinal Neoplasms RESULTS: The best diagnostic performance for distinguishing GIC from CIE was fecal miR-451 (AUC: 0.955, sensitivity: 86.4%, specificity: 100%), miR-223 (AUC: 0.918, sensitivity: 90.9%, specificity: 80%), and miR-27a (AUC: 0.868, sensitivity: 81.8%, specificity: 90%) and serum miR-20b (AUC: 0.905, sensitivity: 90.5%, specificity: 90%), miR-148a-3p (AUC: 0.924, sensitivity: 85.7%, specificity: 90%), and miR-652 (AUC: 0.943, sensitivity: 90.5%, specificity: 90%). +circulation_biomarker_diagnosis_ns 36120988 hsa-mir-20b Inflammatory Bowel Diseases RESULTS: The best diagnostic performance for distinguishing GIC from CIE was fecal miR-451 (AUC: 0.955, sensitivity: 86.4%, specificity: 100%), miR-223 (AUC: 0.918, sensitivity: 90.9%, specificity: 80%), and miR-27a (AUC: 0.868, sensitivity: 81.8%, specificity: 90%) and serum miR-20b (AUC: 0.905, sensitivity: 90.5%, specificity: 90%), miR-148a-3p (AUC: 0.924, sensitivity: 85.7%, specificity: 90%), and miR-652 (AUC: 0.943, sensitivity: 90.5%, specificity: 90%). +circulation_biomarker_diagnosis_ns 36120988 hsa-mir-451 Inflammatory Bowel Diseases RESULTS: The best diagnostic performance for distinguishing GIC from CIE was fecal miR-451 (AUC: 0.955, sensitivity: 86.4%, specificity: 100%), miR-223 (AUC: 0.918, sensitivity: 90.9%, specificity: 80%), and miR-27a (AUC: 0.868, sensitivity: 81.8%, specificity: 90%) and serum miR-20b (AUC: 0.905, sensitivity: 90.5%, specificity: 90%), miR-148a-3p (AUC: 0.924, sensitivity: 85.7%, specificity: 90%), and miR-652 (AUC: 0.943, sensitivity: 90.5%, specificity: 90%). +circulation_biomarker_diagnosis_ns 36120988 hsa-mir-451 Gastrointestinal Neoplasms RESULTS: The best diagnostic performance for distinguishing GIC from CIE was fecal miR-451 (AUC: 0.955, sensitivity: 86.4%, specificity: 100%), miR-223 (AUC: 0.918, sensitivity: 90.9%, specificity: 80%), and miR-27a (AUC: 0.868, sensitivity: 81.8%, specificity: 90%) and serum miR-20b (AUC: 0.905, sensitivity: 90.5%, specificity: 90%), miR-148a-3p (AUC: 0.924, sensitivity: 85.7%, specificity: 90%), and miR-652 (AUC: 0.943, sensitivity: 90.5%, specificity: 90%). +circulation_biomarker_diagnosis_ns 36120988 hsa-mir-223 Gastrointestinal Neoplasms RESULTS: The best diagnostic performance for distinguishing GIC from CIE was fecal miR-451 (AUC: 0.955, sensitivity: 86.4%, specificity: 100%), miR-223 (AUC: 0.918, sensitivity: 90.9%, specificity: 80%), and miR-27a (AUC: 0.868, sensitivity: 81.8%, specificity: 90%) and serum miR-20b (AUC: 0.905, sensitivity: 90.5%, specificity: 90%), miR-148a-3p (AUC: 0.924, sensitivity: 85.7%, specificity: 90%), and miR-652 (AUC: 0.943, sensitivity: 90.5%, specificity: 90%). +circulation_biomarker_diagnosis_ns 36120988 hsa-mir-148a Gastrointestinal Neoplasms RESULTS: The best diagnostic performance for distinguishing GIC from CIE was fecal miR-451 (AUC: 0.955, sensitivity: 86.4%, specificity: 100%), miR-223 (AUC: 0.918, sensitivity: 90.9%, specificity: 80%), and miR-27a (AUC: 0.868, sensitivity: 81.8%, specificity: 90%) and serum miR-20b (AUC: 0.905, sensitivity: 90.5%, specificity: 90%), miR-148a-3p (AUC: 0.924, sensitivity: 85.7%, specificity: 90%), and miR-652 (AUC: 0.943, sensitivity: 90.5%, specificity: 90%). +circulation_biomarker_diagnosis_ns 36120988 hsa-mir-148a Inflammatory Bowel Diseases RESULTS: The best diagnostic performance for distinguishing GIC from CIE was fecal miR-451 (AUC: 0.955, sensitivity: 86.4%, specificity: 100%), miR-223 (AUC: 0.918, sensitivity: 90.9%, specificity: 80%), and miR-27a (AUC: 0.868, sensitivity: 81.8%, specificity: 90%) and serum miR-20b (AUC: 0.905, sensitivity: 90.5%, specificity: 90%), miR-148a-3p (AUC: 0.924, sensitivity: 85.7%, specificity: 90%), and miR-652 (AUC: 0.943, sensitivity: 90.5%, specificity: 90%). +lncRNA target 36120949 hsa-let-7f-1 Wounds and Injuries In conclusion, we demonstrated that NF-kappaB signaling pathway activated by IL-1beta could increase let-7f-5p expression to inhibit IGF-1 production in DETCs and delay wound healing. +lncRNA target 36120949 hsa-let-7f Wounds and Injuries In conclusion, we demonstrated that NF-kappaB signaling pathway activated by IL-1beta could increase let-7f-5p expression to inhibit IGF-1 production in DETCs and delay wound healing. +lncRNA target 36120949 hsa-let-7f Autoimmune Lymphoproliferative Syndrome In conclusion, we demonstrated that NF-kappaB signaling pathway activated by IL-1beta could increase let-7f-5p expression to inhibit IGF-1 production in DETCs and delay wound healing. +lncRNA target 36120949 hsa-let-7f-1 Autoimmune Lymphoproliferative Syndrome In conclusion, we demonstrated that NF-kappaB signaling pathway activated by IL-1beta could increase let-7f-5p expression to inhibit IGF-1 production in DETCs and delay wound healing. +target gene 36120905 hsa-mir-200a Lung Neoplasms Overcoming cisplatin resistance of human lung cancer by sinomenine through targeting the miR-200a-3p-GLS axis. +genetics_overexpression_promote 36120594 hsa-mir-342 Leukemia, Myeloid, Acute Overexpressing or knocking down SOX12 reversed miR +other 36120583 hsa-mir-20a Urinary Bladder Neoplasms We also identified an lncRNA SNHG14/miR-20a-5p/CASP8 regulatory axis in bladder cancer by constructing a ceRNA network. +transcription factor target 36120434 hsa-mir-33a Ovarian Neoplasms In addition, miR-33a-5p bound directly to the 3'UTR of CROT to negatively regulate the expression of CROT and promoted OC cell growth. Thus, targeting the miR-33a-5p/CROT axis may have clinical potential for the treatment of patients with OC. +other 36120427 hsa-mir-195 Diabetes Mellitus, Type 2 The opposite occurred for miR5p in subcutaneous AT. +lncRNA target 36120375 hsa-mir-570 Diabetes Mellitus 3p in diabetic vascular endothelium, and the potential molecular mechanism of vaccarin regulating endothelial inflammatory injury through miR +exosome 36119841 hsa-mir-6068 Prostatic Neoplasms We aimed to determine the levels of small extracellular vesicle (sEV)-associated microRNAs (miRs); miR-4737, miR-6068, and miR-6076 in a large panel of PCa cells and delineate the biological significance of miR-6068 in promoting PCa cells. +genetics_overexpression_promote 36119773 hsa-mir-761 Carcinoma, Hepatocellular Our previous study showed that microRNA-761 (miR-761) is overexpressed in hepatocellular carcinoma (HCC) tissues and that its inhibition affects mitochondrial function and inhibits HCC metastasis. +circulation_biomarker_diagnosis_up 36119459 hsa-mir-129 Leukemia, Myeloid, Acute CircEHBP1 was detected in both nuclear and cytoplasm fractions of AML cells and directly interacted with premature miR-129. +circulation_biomarker_diagnosis_ns 36118948 hsa-mir-142 Thyroid Neoplasms This work aims to explore the risk factors of lung metastasis (LM) in differentiated thyroid cancer (DTC) (LM-DTC) and the effect of treatment and to detect the relationship between LM-DTC and the levels of matrix metalloproteinase-13 (MMP-13) and micro ribonucleic acid (RNA)-142 (miR-142) in peripheral blood. Follicular carcinoma, abnormal expressions of MMP-13, and miR-142 can increase the risk of LM-DTC. +other 36118829 hsa-mir-17 Varicose Veins 5p, miR-1297, miR-20b-5p, and miR-33a-3p. +other 36118829 hsa-mir-20b Varicose Veins 5p, miR-1297, miR-20b-5p, and miR-33a-3p. +other 36118829 hsa-mir-33a Varicose Veins 5p, miR-1297, miR-20b-5p, and miR-33a-3p. +other 36118829 hsa-mir-1297 Varicose Veins 5p, miR-1297, miR-20b-5p, and miR-33a-3p. +other 36118829 hsa-mir-129 Varicose Veins 5p, miR-1297, miR-20b-5p, and miR-33a-3p. +genetics_overexpression_promote 36118827 hsa-mir-1306 Leukemia, Myeloid, Acute 5p and overexpressed miR +lncRNA target 36118276 hsa-mir-150 Nasopharyngeal Carcinoma The clinical significance and potential targets of miR +transcription factor target 36118085 hsa-mir-29a-1 Acute Lung Injury 5p may be a novel therapeutic strategy for preventing ALI. +transcription factor target 36118085 hsa-mir-29a-1 Pulmonary Fibrosis 5p may be a novel therapeutic strategy for preventing ALI. +lncRNA target 36117461 hsa-mir-214 Glioma 3p inhibits TMZ resistance in glioma by promoting CPLX2. +circulation_biomarker_diagnosis_ns 36117315 hsa-mir-132 Epilepsy RESULTS: In the serum of epileptic patients, the level of lncRNA UCA1 and ATG16L1 was reduced and miR +lncRNA target 36116139 hsa-mir-210 Colorectal Neoplasms CONCLUSION: Direct application of the PMIS-miR-210 inhibitor to growing tumours may be an effective colorectal cancer therapeutic. +genetics_knock down_promote 36116109 hsa-mir-532 Femur Head Necrosis In addition, in vivo experiments also confirmed that knockdown of miR +lncRNA target 36115716 hsa-mir-373 Glioblastoma We further found that miR-373 and miR-520s expression was negatively associated with CD44 expression in GBM specimens, and that the miR-373 or miR-520s-CD44 interaction network significantly affected the growth and invasiveness of GBM cells. CONCLUSION: The miR-373 and miR-520s exert their functions by suppressing CD44 expression in GBM cells, and their expression, together with that of CD44, could thus serve as a valuable biomarker of GBM prognosis. +lncRNA target 36115716 hsa-mir-520 Glioblastoma We further found that miR-373 and miR-520s expression was negatively associated with CD44 expression in GBM specimens, and that the miR-373 or miR-520s-CD44 interaction network significantly affected the growth and invasiveness of GBM cells. CONCLUSION: The miR-373 and miR-520s exert their functions by suppressing CD44 expression in GBM cells, and their expression, together with that of CD44, could thus serve as a valuable biomarker of GBM prognosis. +other 36115656 hsa-mir-20 Head and Neck Neoplasms The nanoparticles displayed the pH-responsive release and uptake of Oxa and miR-320 into human tongue squamous carcinoma SAS cells. +exosome 36115547 hsa-mir-506 Adenocarcinoma of Lung Collectively, our findings revealed that exosomal miR-506 sensitized LUAD cells to CDDP-based HT by inhibiting ATAD2/PI3K/AKT signaling pathway, offering a potential therapeutic target for LUAD treatment. +transcription factor target 36114946 hsa-mir-24 pancreatic adenocarcinoma Our data suggest that targeting ASF1B/miR +genetics_overexpression_promote 36114826 hsa-mir-648 Cholangiocarcinoma SKI protein expression was decreased in human CC cells overexpressing miRNA-3648, endogenous SKI protein expression was decreased in human CC tumor tissues, and endogenous SKI mRNA expression was suppressed in human CC cells characterized by rapid growth. +lncRNA target 36114673 hsa-mir-29 Diabetes Mellitus Augmenting physiologic NPGPx expression via experimentally induced miR-29 suppression, using cutaneous tissue nanotransfection or targeted lipid nanoparticle delivery of anti-sense oligonucleotides, proved to be sufficient to overcome the deleterious effects of diabetes on this specific pathway to enhance tissue repair. +other 36114541 hsa-mir-711 Diabetes Mellitus OBJECTIVE: To investigate the regulation of adiponectin/miR-711 on TLR4/NF-kappaB-mediated inflammatory response and diabetic cardiomyocyte apoptosis. Adiponectin/miR-711 reduced myocardial inflammation and apoptosis in diabetic rats. +circRNA target 36114444 hsa-mir-449c Glioblastoma Furthermore, circGLIS3 positively regulated CAPG and GLIS3 by sponging miR-449c-5p to affect GBM cell proliferation and apoptosis. CONCLUSIONS: In summary, our study identified that circGLIS3 could promote proliferation and inhibit apoptosis of GBM cells via targeting miR-449c-5p/GLIS3/CAPG axis in vitro. +other 36114410 hsa-mir-570 Breast Neoplasms In accordance with this hypothesis, we determined a significant role for miR-570 in regulating markers of mammary tumor progression, including cell motility and invasion. +circulation_biomarker_diagnosis_ns 36114255 hsa-mir-29a Alzheimer Disease Some plasma miRNAs (miRNA-92a-3p, miRNA5p, miRNA-29a-3p) are slightly dysregulated in AD, being potential biomarkers of the pathology. +transcription factor target 36114225 hsa-mir-455 Osteoarthritis In addition, We found that EVs derived from TGFbeta3-preconditioned BMSCs rich in miR-455 promoted OA alleviation and cartilage regeneration by activating the SOX11/FOXO signaling pathway. +other 36112753 hsa-mir-155 Hemophilia A MiRNA-155 (p < .05), miRNA-1 (p < .05) and miRNA-197 (p < .05) were significantly higher expressed in CAD and haemophilia patients compared to controls and showed a strong correlation with increased levels of interleukin-6 (IL-6) and soluble intercellular adhesion molecule-1 (sICAM-1). +other 36112753 hsa-mir-155 Atherosclerosis MiRNA-155 (p < .05), miRNA-1 (p < .05) and miRNA-197 (p < .05) were significantly higher expressed in CAD and haemophilia patients compared to controls and showed a strong correlation with increased levels of interleukin-6 (IL-6) and soluble intercellular adhesion molecule-1 (sICAM-1). +other 36112753 hsa-mir-197 Hemophilia A MiRNA-155 (p < .05), miRNA-1 (p < .05) and miRNA-197 (p < .05) were significantly higher expressed in CAD and haemophilia patients compared to controls and showed a strong correlation with increased levels of interleukin-6 (IL-6) and soluble intercellular adhesion molecule-1 (sICAM-1). +other 36112753 hsa-mir-197 Atherosclerosis MiRNA-155 (p < .05), miRNA-1 (p < .05) and miRNA-197 (p < .05) were significantly higher expressed in CAD and haemophilia patients compared to controls and showed a strong correlation with increased levels of interleukin-6 (IL-6) and soluble intercellular adhesion molecule-1 (sICAM-1). +circulation_biomarker_diagnosis_ns 36112335 hsa-mir-195 Breast Neoplasms In this study, a biosensor based on the fluorescence emission of DNA-templated Cu nanoclusters was designed to simultaneously detect and quantify three significant biomarkers of breast cancer (circulating microRNAs, miR-21, miR-195, and miR-155). +circulation_biomarker_diagnosis_ns 36112335 hsa-mir-155 Breast Neoplasms In this study, a biosensor based on the fluorescence emission of DNA-templated Cu nanoclusters was designed to simultaneously detect and quantify three significant biomarkers of breast cancer (circulating microRNAs, miR-21, miR-195, and miR-155). +circulation_biomarker_diagnosis_ns 36112335 hsa-mir-21 Breast Neoplasms In this study, a biosensor based on the fluorescence emission of DNA-templated Cu nanoclusters was designed to simultaneously detect and quantify three significant biomarkers of breast cancer (circulating microRNAs, miR-21, miR-195, and miR-155). +other 36112264 hsa-mir-150 Osteoporosis, Diabetic 5p promotes the osteogenesis of DO rats. +other 36111973 hsa-mir-132 Status Epilepticus "Our previous study found that pro-inflammatory cytokines and miR3p (hereinafter referred to as ""miR-132"") expression were upregulated, but how miR-132 affected reactive astrocyte polarization and neuronal damage during epilepsy is not fully understood." +other 36111973 hsa-mir-132 Parkinson Disease "Our previous study found that pro-inflammatory cytokines and miR3p (hereinafter referred to as ""miR-132"") expression were upregulated, but how miR-132 affected reactive astrocyte polarization and neuronal damage during epilepsy is not fully understood." +other 36111932 hsa-mir-16 Inflammatory Bowel Diseases MiR-16 could serve as a potential biomarker to assess inflammation. +transcription factor target 36111920 hsa-mir-181d Duane Retraction Syndrome OBJECTIVE: Previous studies show the downregulation of miR-181d-5p in the vitreous humor of patients with diabetic retinopathy (DR); however, it is not known whether miR-181d-5p is implicated in the development of DR. CONCLUSIONS: These findings indicate that miR-181d-5p ameliorates HG-stimulated proliferation, migration and angiogenesis of hRMECs through inhibition of VEGFA, which might provide a new target for the treatment of DR. +other 36111920 hsa-mir-181d Diabetic Retinopathy OBJECTIVE: Previous studies show the downregulation of miR-181d-5p in the vitreous humor of patients with diabetic retinopathy (DR); however, it is not known whether miR-181d-5p is implicated in the development of DR. +other 36111773 hsa-mir-1827 Intervertebral Disc Degeneration Analysis of clinical specimens validated that hsa-miR-4534 was upregulated in IDD, whereas hsa-miR-1827 and hsa-miR5p were downregulated in IDD. +other 36111773 hsa-mir-4534 Intervertebral Disc Degeneration Analysis of clinical specimens validated that hsa-miR-4534 was upregulated in IDD, whereas hsa-miR-1827 and hsa-miR5p were downregulated in IDD. +other 36111773 hsa-mir-185 Intervertebral Disc Degeneration Analysis of clinical specimens validated that hsa-miR-4534 was upregulated in IDD, whereas hsa-miR-1827 and hsa-miR5p were downregulated in IDD. +transcription factor target 36111745 hsa-mir-212 Liver Injury Collectively, these findings define a novel mechanism for activating M (3)R to reverse liver injury, which affects hepatocyte proliferation through the Sp1/Gm 2199/miR-212/ERK axis. +genetics_overexpression_suppress 36111570 hsa-mir-513a Leukemia, Myeloid The overexpression of miR-513a-5p inhibited the gene expression level of CASP8 in a human myeloid leukemia cell model (75% change) and the level of a 43-kD fragment of CASP8 protein (P0.70 in the diagnosis of CCA. +exosome 36091107 hsa-mir-4261 Multiple Myeloma CONCLUSIONS: Studies have confirmed that RBCs experience calcium overload in MM with osteolytic lesions, which is related to the downregulation of ATP2B4 by MM exosomal miR-4261. +exosome 36090893 hsa-mir-563 Lung Neoplasms Engineered Exosomes Loaded with miR-563 Inhibit Lung Cancer Growth. +other 36090753 hsa-mir-539 Diabetes Mellitus 5p-Dnmt3b axis might have therapeutic potential for addressing altered skeletal muscle physiology during insulin resistance and type 2 diabetes. +other 36090477 hsa-mir-20b Glioma Purple sweet potato delphinidin-3-rutin represses glioma proliferation by inducing miR-20b-5p/Atg7-dependent cytostatic autophagy. +other 36089762 hsa-mir-29a Tuberculosis CONCLUSIONS: The levels of MiR-29a, Survivin and IFN-gamma was helpful for differential diagnosis of lung cancer and tuberculosis. +other 36089762 hsa-mir-29a Lung Neoplasms CONCLUSIONS: The levels of MiR-29a, Survivin and IFN-gamma was helpful for differential diagnosis of lung cancer and tuberculosis. +transcription factor target 36088985 hsa-mir-149 Inflammation Finally, inhibition of miR-149 by antagomiR-149 blocked LPS-induced depression-like behavior by attenuating LPS-induced expression of NFATc4 in the PFC. +lncRNA target 36088979 hsa-mir-145 Atherosclerosis CONCLUSION: DEHP could accelerate the atherosclerosis process through increasing VSMCs damage and formation of macrophage foam cell by increasing lipid uptake though down regulating lncRNA GAS5 and altering in regulation of miR +lncRNA target 36088911 hsa-mir-155 Carcinoma, Hepatocellular DISCUSSION: RVT inhibits miR-155, activates autophagy, inhibits the toxicity for HepG2.2.15 cells, and reduces HBV replication, providing a new research direction for the treatment of HBV infection. +genetics_overexpression_promote 36088503 hsa-mir-7 Prostatic Neoplasms In present study, we found that expression of miR-7, regulated by p53, was lower in prostate cancer tissues, and miR-7 overexpression significantly mitigated prostate cancer cells growth both in vitro, in organoids and in vivo regardless of p53 status. +other 36088043 hsa-mir-4643 Polycystic Ovary Syndrome 5p, and miR-4643 in FF and CCs compared to control. +other 36088043 hsa-mir-212 Polycystic Ovary Syndrome 5p, and miR-4643 in FF and CCs compared to control. +other 36088043 hsa-mir-490 Polycystic Ovary Syndrome 5p, and miR-4643 in FF and CCs compared to control. +genetics_knock down_promote 36087939 hsa-mir-642a Uterine Cervical Neoplasms Rescue assays showed that NR2F1 knockdown or miR-642a-3p overexpression offset NR2F1-AS1 upregulation-induced inhibition on CC cell malignant phenotypes. +other 36087911 hsa-mir-451 Spinal Cord Injuries CONCLUSIONS: Our findings have highlighted the potential anti-inflammatory role of miR-451 in reducing the secondary neuronal damage after spinal cord injury. +transcription factor target 36087740 hsa-mir-621 Colorectal Neoplasms SIGNIFICANCE: MiR-621 is a vital tumor suppressor in CRC and could be a promising anti-cancer therapeutic target. +genetics_overexpression_promote 36087462 hsa-mir-144 Adenocarcinoma of Lung 5p was significantly down-regulated in LUAD, but overexpression of it repressed proliferation and spheroidization, and promoted apoptosis of LUAD cells. +transcription factor target 36087427 hsa-mir-200b Cleft Palate, Non-Syndromic CONCLUSIONS: We found that differentially expressed miR3p, miR-200 b-3p and miR-130 b-3p may be involved in the pathogenesis of cleft palate by regulating related target genes. +transcription factor target 36087427 hsa-mir-130b Cleft Palate, Non-Syndromic CONCLUSIONS: We found that differentially expressed miR3p, miR-200 b-3p and miR-130 b-3p may be involved in the pathogenesis of cleft palate by regulating related target genes. +transcription factor target 36087427 hsa-mir-212 Cleft Palate, Non-Syndromic CONCLUSIONS: We found that differentially expressed miR3p, miR-200 b-3p and miR-130 b-3p may be involved in the pathogenesis of cleft palate by regulating related target genes. +circRNA target 36087384 hsa-mir-6779 Glioblastoma Subsequently, we observed that circ-0010117 can regulate aggressiveness in glioblastoma cells through miR +genetics_overexpression_promote 36087376 hsa-mir-182 Brain Ischemia CONCLUSION: Our findings suggest that overexpressing miR +genetics_overexpression_promote 36087376 hsa-mir-182 Brain Injuries CONCLUSION: Our findings suggest that overexpressing miR +lncRNA target 36086973 hsa-mir-19a Asthma The down-regulation of miR-19a mRNA by activating JAK/STAT and NF-B signal pathways may be a possible mechanism by which WPCF alleviates airway inflammation. +target gene 36086826 hsa-mir-133a Carcinoma, Hepatocellular APS attenuated PD-L1-mediated immunosuppression via miR-133a-3p in HCC cells. +other 36086747 hsa-mir-944 Adenocarcinoma of Lung In addition, our results reported for the first time that hsa-miR-3944 and hsa-miR-3652 were highly expressed in LUAD. Hsa-miR-3944 and hsa-miR-3652 may serve as new biomarkers in LUAD. +other 36086747 hsa-mir-652 Adenocarcinoma of Lung In addition, our results reported for the first time that hsa-miR-3944 and hsa-miR-3652 were highly expressed in LUAD. Hsa-miR-3944 and hsa-miR-3652 may serve as new biomarkers in LUAD. +genetics_overexpression_promote 36085418 hsa-mir-591 Glioma 3p overexpression in glioma cell lines resulted in G2/M arrest and markedly increased apoptosis. +other 36085307 hsa-mir-155 ABCD syndrome The mechanism underlying ABCD1 and ABCD2 repression involved RNA interference by the EBV-induced microRNAs miR5p and miR-155, respectively, causing significantly increased VLCFA levels. +other 36085307 hsa-mir-9 ABCD syndrome The mechanism underlying ABCD1 and ABCD2 repression involved RNA interference by the EBV-induced microRNAs miR5p and miR-155, respectively, causing significantly increased VLCFA levels. +other 36084428 hsa-mir-181a Carcinoma, Hepatocellular The study demonstrates, for the first time, the OPN isoforms and its modulator miRNA-181a expression in EVs secreted by both cell lines, highlighting high levels of OPN isoforms in EVs secreted by HepG2 and identifying OPN as a promising biomarker for HCC diagnosis. +lncRNA target 36084427 hsa-mir-361 Carcinoma, Hepatocellular 5p inhibited the proliferation, metastasis, invasiveness, and epithelial-to-mesenchymal transition (EMT) process of HCC by targeting the transcription factor Twist1. +other 36084364 hsa-mir-128 Multiple Sclerosis 3p was stably expressed and associated with the PPMS subtype and correlated with disability accumulation. +transcription factor target 36084288 hsa-mir-27b Chemical and Drug Induced Liver Injury These findings suggest that inhibition of miR-27b-3p to activate the Nrf2/ARE pathway by GEN is a potential alternative for hepatic oxidative damage alleviation. +transcription factor target 36084159 hsa-mir-218 Peste-des-Petits-Ruminants Here, we provide evidence that PPRV infection significantly induced the secretion levels of EVs from goat PBMC, and that PPRV-H protein carried in EVs can enhance SLAM receptor expression in the recipient cells via suppressing miR-218, a negative miRNA directly targeting SLAM gene. +other 36083527 hsa-mir-140 Diabetic Nephropathies CONCLUSION: Circ_0080425 expression might contribute to HG-induced endothelial cell injury, and circ_0080425/miR3p/FN1 axis was a potential therapeutic approach to interfere DN process. +lncRNA target 36083475 hsa-mir-21 Ehlers-Danlos Syndrome, musculocontractural type 1 CONCLUSIONS: Our study revealed, for the first time, the ability of Qilan preparation to suppress TSCC cell growth and elucidated that Qilan preparation elicits its anti-cancer actions either the miR-21/PDCD4 or PTEN pathway. +other 36083239 hsa-mir-370 Carcinoma, Hepatocellular 3p in HCC metastasis. +transcription factor target 36082867 hsa-mir-125a Breast Neoplasms OBJECTIVE: We examined the association between miR-125a-5p and STAT3 expression levels in breast cancer patients for the first time through a case-control study on an Iranian population. +circulation_biomarker_diagnosis_up 36082835 hsa-mir-139 Spinal Cord Injuries CONCLUSIONS: All the data found that serum upregulated SNHG3 and downregulated miR +lncRNA target 36082713 hsa-mir-152 Carcinoma, Hepatocellular Conclusion miR-152 may inhibit EMT and RAS of HCCLM3 cells by targeting down-regulation of AGTR1 expression. +other 36082407 hsa-mir-141 Prostatic Neoplasms Here, we examined the expression of miR141-3p, miR145-5p, miR146a-5p, and miR148b-3p in human tissue samples of PCa (n = 41) and benign prostatic diseases (BPD) (n = 30) using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). +other 36082407 hsa-mir-145 Prostatic Neoplasms Here, we examined the expression of miR141-3p, miR145-5p, miR146a-5p, and miR148b-3p in human tissue samples of PCa (n = 41) and benign prostatic diseases (BPD) (n = 30) using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). +other 36082407 hsa-mir-148b Prostatic Neoplasms Here, we examined the expression of miR141-3p, miR145-5p, miR146a-5p, and miR148b-3p in human tissue samples of PCa (n = 41) and benign prostatic diseases (BPD) (n = 30) using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). +other 36082407 hsa-mir-146a Prostatic Neoplasms Here, we examined the expression of miR141-3p, miR145-5p, miR146a-5p, and miR148b-3p in human tissue samples of PCa (n = 41) and benign prostatic diseases (BPD) (n = 30) using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). +lncRNA target 36082081 hsa-mir-21 Reperfusion Injury, Renal Ischemia Our findings underscore the potential utility of future clinical investigations of PPARgamma activation and targeting of the underlying miR-21/PDCD4/caspase-3 pathway, which may participate in the pathogenesis of human IRI. +other 36081896 hsa-mir-17 Alzheimer Disease 5p) were found to be related to MMSE scores. +lncRNA target 36081669 hsa-mir-199a Liver Neoplasms CONCLUSION: With high expression in LC cases, CDKN2B-AS1 is implicated in the development and progression of LC by suppressing cell autophagy through targeting miR-199a-5p. +lncRNA target 36081668 hsa-mir-1 Carcinoma, Non-Small-Cell Lung Moreover, we identified 5 pseudogenes and 33 long non-coding RNAs (lncRNAs) that might inhibit the hsa-miR +other 36081604 hsa-mir-149 COVID-19 5p/RIG-I, IL-6 axis could play a role in regulating the immune response against SARS-CoV-2. +lncRNA target 36081570 hsa-mir-564 Colorectal Neoplasms CONCLUSIONS: Our study demonstrated that lncRNA 604 could promote the progression of CRC via the lncRNA 604/miRNA 564/AEG-1/EMT or lncRNA 604/ZNF326/EMT signaling axis. +other 36081272 hsa-mir-21 Breast Neoplasms MicroRNA-21 (miRNA-21) is a common biomarker with high expression in breast tumors. Therefore, sensitive detection of miRNA-21 is of great significance for clinical breast tumor diagnosis. +other 36081236 hsa-mir-20a Aneuploidy In this study, the BF of 25 blastocysts that had been checked for aneuploidy (aneuploid=17 and euploid=8) was aspirated and the expression of 10 miRNAs (miR-20a, miR-30c, miR-661, miR-372, miR-142, miR-191, miR-345, miR-339, miR-141, and miR-27b) and four genes (ERBB4, SELL, ITGB3, ITGAV) were evaluated using real time-PCR. +other 36081236 hsa-mir-345 Aneuploidy In this study, the BF of 25 blastocysts that had been checked for aneuploidy (aneuploid=17 and euploid=8) was aspirated and the expression of 10 miRNAs (miR-20a, miR-30c, miR-661, miR-372, miR-142, miR-191, miR-345, miR-339, miR-141, and miR-27b) and four genes (ERBB4, SELL, ITGB3, ITGAV) were evaluated using real time-PCR. +other 36081236 hsa-mir-141 Aneuploidy In this study, the BF of 25 blastocysts that had been checked for aneuploidy (aneuploid=17 and euploid=8) was aspirated and the expression of 10 miRNAs (miR-20a, miR-30c, miR-661, miR-372, miR-142, miR-191, miR-345, miR-339, miR-141, and miR-27b) and four genes (ERBB4, SELL, ITGB3, ITGAV) were evaluated using real time-PCR. +other 36081236 hsa-mir-27b Aneuploidy In this study, the BF of 25 blastocysts that had been checked for aneuploidy (aneuploid=17 and euploid=8) was aspirated and the expression of 10 miRNAs (miR-20a, miR-30c, miR-661, miR-372, miR-142, miR-191, miR-345, miR-339, miR-141, and miR-27b) and four genes (ERBB4, SELL, ITGB3, ITGAV) were evaluated using real time-PCR. +other 36081236 hsa-mir-661 Aneuploidy In this study, the BF of 25 blastocysts that had been checked for aneuploidy (aneuploid=17 and euploid=8) was aspirated and the expression of 10 miRNAs (miR-20a, miR-30c, miR-661, miR-372, miR-142, miR-191, miR-345, miR-339, miR-141, and miR-27b) and four genes (ERBB4, SELL, ITGB3, ITGAV) were evaluated using real time-PCR. +other 36081236 hsa-mir-191 Aneuploidy In this study, the BF of 25 blastocysts that had been checked for aneuploidy (aneuploid=17 and euploid=8) was aspirated and the expression of 10 miRNAs (miR-20a, miR-30c, miR-661, miR-372, miR-142, miR-191, miR-345, miR-339, miR-141, and miR-27b) and four genes (ERBB4, SELL, ITGB3, ITGAV) were evaluated using real time-PCR. +other 36081236 hsa-mir-142 Aneuploidy In this study, the BF of 25 blastocysts that had been checked for aneuploidy (aneuploid=17 and euploid=8) was aspirated and the expression of 10 miRNAs (miR-20a, miR-30c, miR-661, miR-372, miR-142, miR-191, miR-345, miR-339, miR-141, and miR-27b) and four genes (ERBB4, SELL, ITGB3, ITGAV) were evaluated using real time-PCR. +other 36081236 hsa-mir-372 Aneuploidy In this study, the BF of 25 blastocysts that had been checked for aneuploidy (aneuploid=17 and euploid=8) was aspirated and the expression of 10 miRNAs (miR-20a, miR-30c, miR-661, miR-372, miR-142, miR-191, miR-345, miR-339, miR-141, and miR-27b) and four genes (ERBB4, SELL, ITGB3, ITGAV) were evaluated using real time-PCR. +transcription factor target 36079691 hsa-mir-29a Testicular Diseases could protect against MTX-induced testicular injury by its antioxidant, anti-inflammatory, antiapoptotic activities and through the regulation of the miRNA-29a testicular expression. +exosome 36078172 hsa-mir-150 Osteoarthritis EV-mediated miR-150-3p can be used to suppress OA, thus providing a novel therapeutic strategy. +genetics_GWAS 36078154 hsa-mir-146a Immune System Diseases We evaluated the expression of miR-146a-5p, a previously described negative regulator of immunity, in infants with respiratory diseases, in order to study epigenetic regulation of the immune response. In conclusion, infants with respiratory diseases present reduced miR-146a-5p expression, possibly affecting immune dysregulation. +genetics_GWAS 36078154 hsa-mir-146a Respiration Disorders, Infant We evaluated the expression of miR-146a-5p, a previously described negative regulator of immunity, in infants with respiratory diseases, in order to study epigenetic regulation of the immune response. In conclusion, infants with respiratory diseases present reduced miR-146a-5p expression, possibly affecting immune dysregulation. +lncRNA target 36078141 hsa-mir-221 Cleidocranial Dysplasia These results demonstrate that OC-lncRNA-mediated osteoclast dysfunction via the OC-lncRNA-miR5p-CXCR3 axis, which is involved in the process of delayed tooth eruption of CCD. +lncRNA target 36078141 hsa-mir-221 Delayed Tooth Eruption These results demonstrate that OC-lncRNA-mediated osteoclast dysfunction via the OC-lncRNA-miR5p-CXCR3 axis, which is involved in the process of delayed tooth eruption of CCD. +other 36078129 hsa-mir-221 Breast Neoplasms Our study reveals a potential improvement in diagnostics by implicating the monitoring of miR-15a+miR-16+miR-221 expression in breast cancer management. +other 36078129 hsa-mir-16 Breast Neoplasms Our study reveals a potential improvement in diagnostics by implicating the monitoring of miR-15a+miR-16+miR-221 expression in breast cancer management. +other 36078129 hsa-mir-15a Breast Neoplasms Our study reveals a potential improvement in diagnostics by implicating the monitoring of miR-15a+miR-16+miR-221 expression in breast cancer management. +other 36078109 hsa-mir-133a Diabetes Mellitus, Type 2 MAO activity in T1D hearts increased miR-133a-3p, -193a-3p and -27a-3p expression. +circulation_biomarker_prognosis_ns 36078082 hsa-mir-222 Carcinoma, Hepatocellular In HCC patients, circulating miR-200c-3p baseline levels were associated with increased survival, whereas high levels of miR +circulation_biomarker_prognosis_ns 36078082 hsa-mir-200c Carcinoma, Hepatocellular In HCC patients, circulating miR-200c-3p baseline levels were associated with increased survival, whereas high levels of miR +circulation_biomarker_prognosis_ns 36078082 hsa-mir-512 Carcinoma, Hepatocellular In HCC patients, circulating miR-200c-3p baseline levels were associated with increased survival, whereas high levels of miR +other 36078059 hsa-mir-126 Diabetes Mellitus, Type 2 miR3p was regulated by both diabetes and H(2)S. +circRNA target 36078046 hsa-mir-370 Metabolic Diseases The potential ceRNA mechanism identified the DEC target miRNAs-mRNAs involved in lipid metabolism, fat deposition, meat quality, and metabolic syndrome via the circRNA-miRNA-mRNA network, concluding that ssc-mir-370 is the most important target miRNA shared by both key circRNAs. +other 36077718 hsa-mir-188 Stomach Neoplasms Hsa_circ_0044301 Regulates Gastric Cancer Cell's Proliferation, Migration, and Invasion by Modulating the Hsa-miR-188-5p/DAXX Axis and MAPK Pathway. +other 36077697 hsa-mir-129 Urinary Bladder Neoplasms DNMT3A/miR-129-2-5p/Rac1 Is an Effector Pathway for SNHG1 to Drive Stem-Cell-like and Invasive Behaviors of Advanced Bladder Cancer Cells. +other 36077665 hsa-mir-145 Thyroid Neoplasms Taken together, the current study suggests that miR-145 may be a biomarker for PTC recurrence. +lncRNA target 36077591 hsa-mir-1 Arrhythmogenic Heart Diseases We tested the new hypothesis that chronic distress, induced by rapid pacing, leads to increased reactive oxygen species, which promotes expression of a micro-RNA, miR-1, specific for the control of Cx43. In light of the high arrhythmogenic potential of altered Cx43 expression, we propose miR-1 as a novel target for pharmacological interventions to prevent the maladaptive remodeling processes during chronic distress in the heart. +lncRNA target 36077546 hsa-mir-6881 Carcinoma, Hepatocellular AIM: Investigate the pharmacological activity and potential mechanism of rosavin treatment on NASH management via targeting hepatic cell death-related (HSPD1/TNF/MMP14/ITGB1) mRNAs and their upstream noncoding RNA regulators (miRNA5P and lnc-SPARCL1-1:2) in NASH rats. +lncRNA target 36077546 hsa-mir-6881 Hepatitis AIM: Investigate the pharmacological activity and potential mechanism of rosavin treatment on NASH management via targeting hepatic cell death-related (HSPD1/TNF/MMP14/ITGB1) mRNAs and their upstream noncoding RNA regulators (miRNA5P and lnc-SPARCL1-1:2) in NASH rats. +lncRNA target 36077546 hsa-mir-6881 Pulmonary Fibrosis AIM: Investigate the pharmacological activity and potential mechanism of rosavin treatment on NASH management via targeting hepatic cell death-related (HSPD1/TNF/MMP14/ITGB1) mRNAs and their upstream noncoding RNA regulators (miRNA5P and lnc-SPARCL1-1:2) in NASH rats. +genetics_overexpression_promote 36077521 hsa-mir-143 Leukemia 3p overexpression in two T-ALL cell lines. +genetics_overexpression_promote 36077521 hsa-mir-143 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 3p overexpression in two T-ALL cell lines. +other 36077457 hsa-mir-21 Cardiomyopathy, Dilated In IHF patients, we observed elevated TNKS2 and DICER and concomitant upregulation of miR-34a-5p and miR5p in non-infarcted myocardium. +other 36077457 hsa-mir-21 Heart Failure, Ischemic In IHF patients, we observed elevated TNKS2 and DICER and concomitant upregulation of miR-34a-5p and miR5p in non-infarcted myocardium. +other 36077457 hsa-mir-34a Heart Failure, Ischemic In IHF patients, we observed elevated TNKS2 and DICER and concomitant upregulation of miR-34a-5p and miR5p in non-infarcted myocardium. +other 36077457 hsa-mir-34a Cardiomyopathy, Dilated In IHF patients, we observed elevated TNKS2 and DICER and concomitant upregulation of miR-34a-5p and miR5p in non-infarcted myocardium. +circulation_biomarker_diagnosis_ns 36077347 hsa-mir-142 Myocardial Infarction In conclusion, the increased plasma levels of mtDNA, along with miR +transcription factor target 36077117 hsa-mir-223 Arthritis, Rheumatoid Furthermore, our data indicate that LSF, a selective inhibitor of STAT4, should be an ideal therapeutic agent for treating RA through down-regulating miRassociated osteoclastogenesis. +lncRNA target 36077054 hsa-mir-532 Breast Neoplasms We show that both ADAR1 and METTL3 are upregulated in breast cancer samples, and ADAR1 positively correlates with METTL3; ADAR1 edits METTL3 mRNA and changes its binding site to miR532-5p, leading to increased METTL3 protein, which further targets ARHGAP5, recognized by YTHDF1. +circulation_biomarker_prognosis_up 36077039 hsa-mir-99b Prostatic Neoplasms Transfection of the miR-99b-5p mimic resulted in a significant reduction in nuclear mTOR and androgen receptor (AR), while a slight/moderate to no decrease in cytoplasmic mTOR and AR in PCa and other cancer cells, suggesting that miR-99b-5p inhibits mTOR and AR expression and their nuclear translocation. +lncRNA target 36077031 hsa-mir-133a Fibrosis, Atrial In conclusion, MiRNA let-7a, miR-let-7e and miR-133a play important roles in hypoxia-related atrial fibrosis by inhibiting collagen expression and post-transcriptional repression by the JNK pathway. +lncRNA target 36077031 hsa-let-7e Fibrosis, Atrial In conclusion, MiRNA let-7a, miR-let-7e and miR-133a play important roles in hypoxia-related atrial fibrosis by inhibiting collagen expression and post-transcriptional repression by the JNK pathway. +circulation_biomarker_prognosis_ns 36076930 hsa-mir-200 Breast Neoplasms The extracellular circulating microRNA (miR)-200 regulates epithelial-mesenchymal transition and, thus, plays an essential role in the metastatic cascade and has shown itself to be a promising prognostic and predictive biomarker in metastatic breast cancer (MBC). In MBC patients, circulating miR-200 family members decreased after one cycle of a new line of systemic therapy, were elevated during PD, and were indicative of CTC status. +other 36076541 hsa-mir-148a Atherosclerosis The contribution of miR-148a-3p to the progression of atherosclerosis is unknown. CONCLUSIONS: Therapeutic silencing of miR148a mitigated the progression of atherosclerosis and promoted plaque stability. +other 36076541 hsa-mir-148 Atherosclerosis The contribution of miR-148a-3p to the progression of atherosclerosis is unknown. CONCLUSIONS: Therapeutic silencing of miR148a mitigated the progression of atherosclerosis and promoted plaque stability. +other 36076490 hsa-mir-181b Reperfusion Injury, Cerebral Ischemia Our findings showed that BV could significantly improve CIR injury, both in vivo and in vitro, decrease LncRNA H19 and Esm1 expression, and increase miR-181b-5p expression. In conclusion, this study found that BV could ameliorate CIR injury by regulating the LncRNA H19/miR-181b-5p/Esm1 axis. +lncRNA target 36076481 hsa-mir-126 Diabetic Nephropathies Due to the results, diabetes aggravates acute myocardial ischemia-reperfusion-induced kidney injury, while moderate-intensity interval training and Crataegus persica treatment simultaneously ameliorate myocardial ischemia-reperfusion-induced renal injury via miR-126/Nrf-2 pathway and improve insulin sensitivity and renal function in type 1 diabetic rats. +lncRNA target 36076481 hsa-mir-126 Diabetes Mellitus Due to the results, diabetes aggravates acute myocardial ischemia-reperfusion-induced kidney injury, while moderate-intensity interval training and Crataegus persica treatment simultaneously ameliorate myocardial ischemia-reperfusion-induced renal injury via miR-126/Nrf-2 pathway and improve insulin sensitivity and renal function in type 1 diabetic rats. +other 36076347 hsa-mir-202 Sjogren's Syndrome Hsa-miR-3202 was lower expressed in primary Sjogren's syndrome than healthy control. +other 36076300 hsa-mir-662 Graves Ophthalmopathy Key TFs regulating genes in the TED-associated coexpression network, including NFRKB, ZNF711, ZNF407 and MORC2, and miRs including hsa-miR-144, hsa-miR-3662, hsa-miR-12136 and hsa-miR-3646, were identified. +other 36076300 hsa-mir-144 Graves Ophthalmopathy Key TFs regulating genes in the TED-associated coexpression network, including NFRKB, ZNF711, ZNF407 and MORC2, and miRs including hsa-miR-144, hsa-miR-3662, hsa-miR-12136 and hsa-miR-3646, were identified. +other 36076300 hsa-mir-646 Graves Ophthalmopathy Key TFs regulating genes in the TED-associated coexpression network, including NFRKB, ZNF711, ZNF407 and MORC2, and miRs including hsa-miR-144, hsa-miR-3662, hsa-miR-12136 and hsa-miR-3646, were identified. +other 36076300 hsa-mir-12136 Graves Ophthalmopathy Key TFs regulating genes in the TED-associated coexpression network, including NFRKB, ZNF711, ZNF407 and MORC2, and miRs including hsa-miR-144, hsa-miR-3662, hsa-miR-12136 and hsa-miR-3646, were identified. +other 36076283 hsa-mir-155 Alzheimer Disease The protective effects of microglial miR-155 ablation should shed light on potential treatments for retinal inflammation and vascular damage during AD and other ocular diseases. +circulation_biomarker_diagnosis_ns 36076132 hsa-mir-219 Meningioma The serum level of miR-219 was studied in 56 meningioma samples WHO grade I = 22, WHO grade II = 14, and WHO grade III = 20). +lncRNA target 36076093 hsa-mir-454 Cardiomyopathy, Dilated Enrichment analysis for the potential targeted mature mRNAs by miR +lncRNA target 36076093 hsa-mir-194 Cardiomyopathy, Dilated Enrichment analysis for the potential targeted mature mRNAs by miR +exosome 36075289 hsa-mir-7219 Silicotuberculosis In brief, our results demonstrated that exosomal miR3p played an important role in FMT and might be a novel therapeutic target of silicosis. +other 36075249 hsa-mir-124 Inflammatory Bowel Diseases ABX464 (obefazimod) for moderate-to-severe, active ulcerative colitis: a phase BACKGROUND: ABX464 (obefazimod) is a small molecule that selectively upregulates miR-124 in immune cells. +genetics_GWAS 36075029 hsa-mir-146a Inflammatory Bowel Diseases The miR-146a rs2910164 C allele was significantly associated with increased risk of UC. In conclusion, miR-146a rs2910164 polymorphism may play a role in UC. +lncRNA target 36074900 hsa-mir-365 Anovulation In summary, our findings reveal a cis-acting regulation mechanism of CYP11A1 through lncRNA, and define a novel signaling pathway, lnc2300/miR3p/CYP11A1 axis, which is involved in the regulation of GC apoptosis and follicular atresia. +circulation_biomarker_diagnosis_up 36074605 hsa-mir-132 Pneumonia MATERIALS AND METHODS: Plasma samples were obtained from patients with pneumonia (n = 98) and healthy controls (n = 98) to detect the expression of circulating Arid2-IR and miR +circulation_biomarker_diagnosis_up 36074605 hsa-mir-132 Acute Lung Injury MATERIALS AND METHODS: Plasma samples were obtained from patients with pneumonia (n = 98) and healthy controls (n = 98) to detect the expression of circulating Arid2-IR and miR +lncRNA target 36074434 hsa-mir-675 Tongue Neoplasms CONCLUSIONS: Ginsenoside Rd inhibits tongue cancer cell migration and invasion via the H19/miR +genetics_overexpression_suppress 36074324 hsa-mir-21 Choriocarcinoma 5p overexpression and HIF1AN downregulation. +lncRNA target 36074257 hsa-mir-34b Neurotoxicity Syndromes Moreover, OIP5-AS1 could bind to miR-34b and OIP5-AS1 regulated BUP-induced neurotoxicity via miR-34b. In sum, our results disclosed that OIP5-AS1 ameliorated BUP-caused neurotoxicity via regulating the miR-34b/NFAT5 axis, suggesting that OIP5-AS1 might be a promising therapeutic target for the treatment of BUP-induced neurotoxicity. +transcription factor target 36074090 hsa-mir-181 Colitis As epithelial reconstitution is crucial to restore intestinal homeostasis after injury, the miR-181 family represents a potential therapeutic target against severe intestinal inflammation. +circRNA target 36073553 hsa-mir-203a Inflammation In summary, our data revealed that circ_0123996 promoted the proliferation, inflammation, and fibrosis of mesangial cells via modulating the miR-203a-3p/SOX6 axis, suggesting that circ_0123996 might be a target for alleviating DN progression. +circRNA target 36073553 hsa-mir-203a Diabetic Nephropathies In summary, our data revealed that circ_0123996 promoted the proliferation, inflammation, and fibrosis of mesangial cells via modulating the miR-203a-3p/SOX6 axis, suggesting that circ_0123996 might be a target for alleviating DN progression. +lncRNA target 36073344 hsa-let-7b COVID-19 These data suggest the involvement of hsa-let7b-5p in the regulation of genes necessary for SARS-CoV-2 infections and its putative role as a therapeutic target for COVID-19. +transcription factor target 36073218 hsa-mir-372 Colorectal Neoplasms 5p activates PI3K/AKT signaling pathway by targeting PTEN and up-regulates CXCL12 expression to promoting metastasis of colorectal cancer cells. +other 36072958 hsa-mir-21 Fibrosis functionalized Ti substrates. +genetics_overexpression_promote 36072902 hsa-mir-122 Carcinoma, Renal Cell Overexpression of miR-29a-3p or miR +genetics_overexpression_promote 36072902 hsa-mir-29a Carcinoma, Renal Cell Overexpression of miR-29a-3p or miR +other 36072900 hsa-mir-106a Polycystic Ovary Syndrome Meanwhile, the area under curve of receiver operating characteristic revealed that hsa-miR-196a-3p, hsa-miR5p, hsa-miR-106a-3p, hsa-miR-34a-5p, and hsa-miR-20a-5p were potential biomarkers for the diagnosis of PCOS. +other 36072900 hsa-mir-34a Polycystic Ovary Syndrome Meanwhile, the area under curve of receiver operating characteristic revealed that hsa-miR-196a-3p, hsa-miR5p, hsa-miR-106a-3p, hsa-miR-34a-5p, and hsa-miR-20a-5p were potential biomarkers for the diagnosis of PCOS. +other 36072900 hsa-mir-20a Polycystic Ovary Syndrome Meanwhile, the area under curve of receiver operating characteristic revealed that hsa-miR-196a-3p, hsa-miR5p, hsa-miR-106a-3p, hsa-miR-34a-5p, and hsa-miR-20a-5p were potential biomarkers for the diagnosis of PCOS. +other 36072900 hsa-mir-196a Polycystic Ovary Syndrome Meanwhile, the area under curve of receiver operating characteristic revealed that hsa-miR-196a-3p, hsa-miR5p, hsa-miR-106a-3p, hsa-miR-34a-5p, and hsa-miR-20a-5p were potential biomarkers for the diagnosis of PCOS. +other 36072900 hsa-mir-143 Polycystic Ovary Syndrome Meanwhile, the area under curve of receiver operating characteristic revealed that hsa-miR-196a-3p, hsa-miR5p, hsa-miR-106a-3p, hsa-miR-34a-5p, and hsa-miR-20a-5p were potential biomarkers for the diagnosis of PCOS. +genetics_knock down_promote 36072768 hsa-mir-497 Depression Knockdown of BDNF could abrogate the improving influences of miR +circulation_biomarker_diagnosis_up 36072634 hsa-mir-34 Hemoptysis The efficacy, overall survival (OS) rate, coagulation function, hemoptysis volume, serum tumor markers, and miR-34 expression are compared among all groups at different time points. +circulation_biomarker_diagnosis_up 36072634 hsa-mir-34 Lung Neoplasms The efficacy, overall survival (OS) rate, coagulation function, hemoptysis volume, serum tumor markers, and miR-34 expression are compared among all groups at different time points. +other 36072623 hsa-mir-182a Ovarian Neoplasms Malignant ovarian carcinoma cells recovered following miR-182A-3p downregulation. TYMP1 sequesters miR-182A-3p and promotes TGF1B in ovarian carcinoma, boosting carcinogenesis and cisplatin resistance. +genetics_knock down_promote 36072619 hsa-mir-10b Mouth Neoplasms Finally, it was discovered that AKT signaling participates in regulating exosome-mediated invasion and migration of oral cancer cells and its activation reduced the inhibitory effect of miR-10b knockdown on oral cancer cells. +lncRNA target 36072399 hsa-mir-378a Rhinitis, Allergic CONCLUSIONS: MiR-378a-3p can accelerate the pathological development of AR through targeted inhibition on the release of pro-inflammatory factors such as IgE and HA activated by GzmB, so it is a promising molecular target of AR therapy and offers a novel research direction for the complete cure of AR. +other 36072391 hsa-mir-105a bladder urothelial carcinoma RT-qPCR confirmed that four miRNAs are significantly downregulated in UC compared to healthy urothelial samples (miR-105a, miR-143, miR-181a, and miR-214). +other 36072391 hsa-mir-214 bladder urothelial carcinoma RT-qPCR confirmed that four miRNAs are significantly downregulated in UC compared to healthy urothelial samples (miR-105a, miR-143, miR-181a, and miR-214). +other 36072391 hsa-mir-181a bladder urothelial carcinoma RT-qPCR confirmed that four miRNAs are significantly downregulated in UC compared to healthy urothelial samples (miR-105a, miR-143, miR-181a, and miR-214). +other 36072391 hsa-mir-143 bladder urothelial carcinoma RT-qPCR confirmed that four miRNAs are significantly downregulated in UC compared to healthy urothelial samples (miR-105a, miR-143, miR-181a, and miR-214). +lncRNA target 36071871 hsa-mir-138 Carcinoma, Hepatocellular 5p/HIF-1alpha as a potential therapeutic target for sensitizing HCC to radiotherapy. +lncRNA target 36071684 hsa-mir-2681 Atherosclerosis Taken together, these findings indicated that lncRNA_FGF7-5 and lncRNA_GLRX3 together reduced atherosclerosis-induced apoptosis of HUVECs via targeting miR5p to increase ERCC4 expression, thereby preventing the formation of carotid plaque and finally inhibiting atherosclerosis progression. +lncRNA target 36071684 hsa-mir-2681 Carotid Artery Diseases Taken together, these findings indicated that lncRNA_FGF7-5 and lncRNA_GLRX3 together reduced atherosclerosis-induced apoptosis of HUVECs via targeting miR5p to increase ERCC4 expression, thereby preventing the formation of carotid plaque and finally inhibiting atherosclerosis progression. +lncRNA target 36071682 hsa-mir-193a AIDS-Related Complex In conclusion, circMAP3K4 protected SRA01/04 cells from H(2)O(2)-induced dysfunction in ARC through mediating miR-193a-3p/PLCD3 axis. +lncRNA target 36071678 hsa-mir-513a Colonic Neoplasms Therefore, we identified that circPLOD2 promoted colon cancer progression through miR-513a-5p/SIX1/LDHA axis, and acted as a new biomarker for colon cancer prognosis and treatment. +genetics_overexpression_promote 36071480 hsa-mir-383 Carcinoma, Hepatocellular Either downregulation of MCUR1 or overexpression of miR-383 improved DOX sensitivity in HCC cells. +genetics_overexpression_promote 36071475 hsa-mir-26a Neuralgia In addition, Foxy5, a mimetic peptide of Wnt5a, can significantly reverse the inhibitory effect of miR-26a-5p on neuroinflammation and neuropathic pain, and at the same time, miR-26a-5p can rescue the effect of Foxy5 by overexpression. +exosome 36071344 hsa-mir-199a Pre-Eclampsia Our previous study implied the important role of exosomal miR-199a-5p in preeclampsia with severe features (sPE). Furthermore, exosomal miR-199a-5p could impair the endothelial cell function via targeting SIRT1, contributing to the development of preeclampsia. +genetics_GWAS 36071121 hsa-mir-145 Asthma We hypothesize that single nucleotide polymorphisms (SNPs) in the promoter region of miR-145 may be associated with the risk of asthma in Taiwanese. +circulation_biomarker_diagnosis_up 36070969 hsa-mir-455 Fractures, Bone RESULTS: Serum miR +circulation_biomarker_diagnosis_up 36070969 hsa-mir-455 Osteoporosis RESULTS: Serum miR3p was significantly decreased in both osteoporosis and fragility fracture patients compared with the control group, which was most deficient in patients with fragility fracture. +lncRNA target 36070614 hsa-mir-1 Cardiomegaly In summary, our study identified the modulatory role linc-RMRP played in regulating PE-induced CH by means of binding miR-1, and this might provide a new target for cardiac hypertrophy therapy. +circulation_biomarker_diagnosis_ns 36069974 hsa-mir-542 Pneumonia, Mycoplasma CONCLUSIONS: Downregulation of LINC00221 might reduce dysfunction, inflammatory responses, endoplasmic reticulum stress, and oxidative stress, and thereby protect against PE by augmenting miR3p. +circRNA target 36069177 hsa-mir-200c Fibrosis, Renal circACTR2, by targeting and sponging miR-200c, activates YAP signalling, stimulates M2 macrophage polarization and promotes the development of RF. +circulation_biomarker_diagnosis_ns 36068979 hsa-mir-16 Coronary Artery Disease Plasma levels of miR-21, miR-27b, miR-122, miR-125b, miR-146b, miR-147b, and miR-155 were lower and plasma levels of miR-16 and miR-92a were higher in patients with early onset coronary artery disease compared to older patients with late-onset coronary artery disease. +circulation_biomarker_diagnosis_ns 36068979 hsa-mir-21 Coronary Artery Disease Plasma levels of miR-21, miR-27b, miR-122, miR-125b, miR-146b, miR-147b, and miR-155 were lower and plasma levels of miR-16 and miR-92a were higher in patients with early onset coronary artery disease compared to older patients with late-onset coronary artery disease. +circulation_biomarker_diagnosis_ns 36068979 hsa-mir-92a Coronary Artery Disease Plasma levels of miR-21, miR-27b, miR-122, miR-125b, miR-146b, miR-147b, and miR-155 were lower and plasma levels of miR-16 and miR-92a were higher in patients with early onset coronary artery disease compared to older patients with late-onset coronary artery disease. +genetics_overexpression_promote 36068615 hsa-mir-369 Intervertebral Disc Degeneration RESULTS: Western blotting, qPCR, and flow cytometry analyses confirmed that overexpression of circ_7042 could downregulate miR +lncRNA target 36068004 hsa-mir-892b Urinary Bladder Neoplasms Reduction of miR-892b relieved si-circ_0003221-induced anti-tumor response in BLCA cells. CONCLUSIONS: The current evidence elucidated circ_0003221 targeted miR-892b to elevate the DHCR24 level, thus accelerating cell development and glycolytic metabolism of BLCA cells. +lncRNA target 36067951 hsa-mir-423 Reperfusion Injury, Cerebral Ischemia In conclusion, inhibition of miR +lncRNA target 36067544 hsa-mir-33a Osteosarcoma Furthermore, it was verified that JPX acts as a sponge for miR-33a-5p, and that JPX regulated OS cell proliferation, migration and invasion through miR-33a-5p. Moreover, down-regulation of miR-33a-5p in OS contributed to PNMA1 upregulation, and PNMA1 depletion inhibited OS cell proliferation, migration and invasion in vitro. +lncRNA target 36067543 hsa-mir-3163 Colorectal Neoplasms Subsequently, we testified that FAM201A exerted its role in the tumorigenesis and development of CRC through targeting miR-3163/MACC1. In conclusion, our study was the first to unveil that FAM201A promoted cell proliferation and CSC characteristics in CRC via regulation of the miR-3163/MACC1 axis, which provided clues for the clinical treatment of patients with this disease. +circRNA target 36067529 hsa-mir-651 Colorectal Neoplasms Circ_0000467 may enhance the growth and metastasis of CRC cells by targeting miR +other 36067193 hsa-mir-1 Spinal Cord Injuries CONCLUSION: Our experiment demonstrated that miR-31 could promote the migration of BMSCs and miR-31 could repair and improve the function of damaged tissues in SCI. +genetics_overexpression_suppress 36067091 hsa-mir-200c Thyroid Carcinoma, Anaplastic Overexpression of miR-200c inhibited the invasion, proliferation, and colony formation of the ATC cell lines, whereas its downregulation achieved the opposite results. +other 36066909 hsa-mir-103a Pulmonary Disease, Chronic Obstructive In this study, we found that miR-103a expression was significantly reduced in alveolar macrophages from smokers and patients with COPD versus that in alveolar macrophages from nonsmokers. Taken together, our findings indicate that downregulation of miR-103a contributes to cigarette smoke-induced lipid-laden macrophage formation and plays a critical role in lipid homeostasis in lung macrophages in the pathogenesis of COPD. +lncRNA target 36066507 hsa-mir-623 Glioblastoma RP11-89 suppressed the role of miR-623 in downregulating cyclin D1 and GBM cell proliferation. +genetics_overexpression_promote 36066402 hsa-mir-299 Lung Neoplasms 3p inhibitor or SLC38A1 overexpression attenuated OGFRP1 depletion-induced suppression on cell proliferation and ferroptosis in lung cancer. +genetics_knock down_promote 36066401 hsa-mir-449a Thyroid Cancer, Papillary CircMAN1A2 acted as a molecular sponge of miR-449a, and circMAN1A2 knockdown suppressed PTC development partly through upregulating miR-449a. +circRNA target 36066399 hsa-mir-31 Carcinoma, Non-Small-Cell Lung In-vivo analysis indicated that circHMGA2 inhibition also reduced tumorigenesis and glycolysis of NSCLC via the miR +lncRNA target 36066393 hsa-mir-199a Carcinoma, Non-Small-Cell Lung In addition, miR-199a-5p exerts an inhibitory effect in NSCLC cells by inhibiting SphK2. This research demonstrated that circ_0007841 had a positive influence in improving NSCLC development by targeting miR-199a-5p and upregulating oncogene SphK2. +other 36066383 hsa-mir-370 Lymphoma, Large B-Cell, Diffuse Our findings revealed that circ_0000877 could regulate the malignant evolution of DLBCL by miR3p/MAP4K4/Hippo pathway. +lncRNA target 36066055 hsa-mir-186 Trigeminal Neuralgia 5p in a rat model (adult male Sprague-Dawley rats, 7-8 weeks old, 180-200 g) of trigeminal neuralgia (TN) established via chronic constriction injury of the infraorbital nerve (ION-CCI). +other 36065995 hsa-mir-124 Ischemic Stroke The combination of Ca-MOF@miR-124 nanoparticles and NSC therapy will enhance the treatment of traumatic nerve injury and neurodegenerative diseases. +genetics_overexpression_suppress 36065643 hsa-mir-148a Carcinoma, Hepatocellular miR-148a-3p mimic-mediated apoptosis and the inhibition of HCC cell growth and migration were counteracted by CTSA overexpression. +circulation_biomarker_diagnosis_up 36065413 hsa-mir-486 Obesity RESULTS: Among 16 miRNAs that were revealed to be associated with obesity in previous studies and showed expression levels that were high enough for a reasonable comparison, serum levels of 3 miRNAs displayed significant differences between the Austrian and Japanese groups: miR-125b +circulation_biomarker_diagnosis_up 36065413 hsa-mir-20a Obesity RESULTS: Among 16 miRNAs that were revealed to be associated with obesity in previous studies and showed expression levels that were high enough for a reasonable comparison, serum levels of 3 miRNAs displayed significant differences between the Austrian and Japanese groups: miR-125b +circulation_biomarker_diagnosis_up 36065413 hsa-mir-125b-1 Obesity RESULTS: Among 16 miRNAs that were revealed to be associated with obesity in previous studies and showed expression levels that were high enough for a reasonable comparison, serum levels of 3 miRNAs displayed significant differences between the Austrian and Japanese groups: miR-125b +lncRNA target 36065412 hsa-mir-604 Colorectal Neoplasms circ_0052184 promoted the occurrence and development of colorectal cancer by targeting the miR-604/HOXA9 axis. +other 36065304 hsa-mir-16 Colonic Neoplasms 5p, and miR-200a-5p was closely associated with overall survival (OS) of samples and tumor metastasis in COAD. +other 36065304 hsa-mir-141 Colonic Neoplasms 5p, and miR-200a-5p was closely associated with overall survival (OS) of samples and tumor metastasis in COAD. +other 36065304 hsa-mir-200a Colonic Neoplasms 5p, and miR-200a-5p was closely associated with overall survival (OS) of samples and tumor metastasis in COAD. +other 36065304 hsa-mir-148a Colonic Neoplasms 5p, and miR-200a-5p was closely associated with overall survival (OS) of samples and tumor metastasis in COAD. +other 36064821 hsa-mir-672 Neuralgia 5p directly regulated the expression of REEP6, which participated in the neuronal hyperexcitability in the spinal dorsal horn and neuropathic pain following BTZ treatment. +lncRNA target 36064768 hsa-mir-30 Brain Injuries, Traumatic 5p, SHED-EVs favored anti-inflammatory microglia polarization through Ehmt2 mediated CXCL14 transcription in treating traumatic brain injury. +lncRNA target 36064706 hsa-mir-32 Colorectal Neoplasms CONCLUSION: In summary, we propose that in CRC, poised chromatin and miR-32 decrease the expression of MARCH8, further bind and add ubiquitin, induce HK2 degradation, and finally repress glycolysis to promote tumor suppressors in CRC. +transcription factor target 36064576 hsa-mir-590 Triple Negative Breast Neoplasms MiR3p directly targeted the TRAIP 3'-UTR, and its expression were lower in TNBC tissues. +circRNA target 36064433 hsa-mir-199b Leukemia, Lymphocytic, Chronic, B-Cell Mechanistically, circRIC8B acted as a sponge of miR-199b-5p and prevented it from decreasing the level of LPL mRNA, and this promotes lipid metabolism alteration and facilitates the progression of CLL. Our findings revealed that circRIC8B regulates the lipid metabolism abnormalities in and development of CLL through the miR-199b-5p/LPL axis. +other 36064409 hsa-mir-885 Stomach Neoplasms 3p, thereby promoting GC development. +genetics_overexpression_suppress 36064348 hsa-mir-18a Squamous Cell Carcinoma of Head and Neck Furthermore, the migration and invasion abilities of OSCC cells were significantly decreased by miRNA-18a mimics and significantly increased by the overexpression of HIF-1alpha under hypoxic conditions relative to those abilities in cells treated only with miRNA-18a mimics. +lncRNA target 36064035 hsa-mir-29b Aortic Valve Disease Then, we found that miR-29b participated in the NLRP3-regulated CAVD pathway through its target gene STAT3 (signal transducer and activator of transcription 3). +genetics_overexpression_suppress 36063796 hsa-mir-204 Carcinoma, Renal Cell 5p restored the promoting impact of overexpression of GXYLT2 on malignant progression of ccRCC cells. +lncRNA target 36063543 hsa-mir-197 Polycystic Ovary Syndrome 3p exhibits a negative regulatory role in regulating granulosa ovarian cell proliferation via posttranscriptional repression of CUL3 in PCOS. +circRNA target 36063260 hsa-mir-1178 Pancreatic Carcinoma 3p and increasing BNIP3, implying the potential implication of circDUSP22 in targeted therapy of PaCa. +other 36062491 hsa-mir-148a Obesity Those results suggested that Ago2-miR-148a-AMPKalpha signaling pathway play an important function in the developing obesity and adiposity, and will further provide basic research data for the potential clinical treatment of obesity. +other 36062412 hsa-mir-200c Colonic Neoplasms In PDCs, miR-141, miR-200c, and CDH1 were significantly downregulated. +other 36062412 hsa-mir-141 Colonic Neoplasms In PDCs, miR-141, miR-200c, and CDH1 were significantly downregulated. +lncRNA target 36062277 hsa-mir-494 Carcinoma, Hepatocellular CONCLUSIONS: EPS1-1 protected against HCC by limiting its proliferation and survival through the miR +target gene 36062165 hsa-mir-21 Colorectal Neoplasms LncRNA GAS5 Suppresses Colorectal Cancer Progress by Target miR-21/LIFR Axis. +epigenetics 36061358 hsa-mir-613 Nasopharyngeal Carcinoma Collectively, miR-613 inhibited DNMT3B, reduced TIMP3 methylation, and increased TIMP3 protein level, thus inhibiting the STAT1/FOXO1 pathway and enhancing the radiosensitivity of NPC cells. +genetics_knock down_promote 36061355 hsa-mir-22 Colorectal Neoplasms Additional functional experiments confirmed that MAX overexpression can rescue the effects of miR-22 on the behavior of CRC cells. +other 36061211 hsa-mir-422a Inflammatory Bowel Diseases CTLA4, which has immune-related properties, can be a potential biomarker in UC, and MIAT/miR-422a/CTLA4 ceRNA networks may play important roles in UC. +lncRNA target 36061185 hsa-mir-33a Glioma We found that hsa-mir-33a co-targeting FOSL1 and EN2 has a good predictive value for glioblastoma and skeletal muscle reduction. +lncRNA target 36061185 hsa-mir-33a Sarcopenia We found that hsa-mir-33a co-targeting FOSL1 and EN2 has a good predictive value for glioblastoma and skeletal muscle reduction. +exosome 36061148 hsa-mir-3960 Osteoarthritis We aimed to investigate the effects of EV-encapsulated miR-3960 derived from MSCs on chondrocyte injury in OA. +exosome 36061148 hsa-mir-3960 Cartilage Diseases We aimed to investigate the effects of EV-encapsulated miR-3960 derived from MSCs on chondrocyte injury in OA. +genetics_overexpression_promote 36060928 hsa-mir-212 Cardiomegaly The overexpression of miR-212 adenovirus was constructed, and the expression of miR-212 was overexpressed, and its effect on cardiac hypertrophy (CH) was detected by immunofluorescence and qRT-PCR. +lncRNA target 36060794 hsa-mir-942 Hypertension, Pulmonary Conclusion Our findings demonstrated that diminished circGSAP accelerated cell cycle to facilitate cell proliferation and apoptosis resistance through competitively binding miR5p to modulate SMAD4 expressions in hypoxia-induced PMECs, indicating potential therapeutic strategies for PH. +other 36060256 hsa-mir-873 Thyroid Neoplasms CYTOR-hsa-miRNA5p-CDKN2A regulatory networks and single copy number deletion of CDKN2A may also affect THCA' progression and prognosis. +lncRNA target 36060149 hsa-mir-185 Carcinoma, Non-Small-Cell Lung Our data suggested that LINC00174 aggravated LUSC progression via serving as a competing endogenous RNA (ceRNA) to sponge miR5p and ultimately upregulate NFIX, which offered a promising novel target for LUSC therapy. +lncRNA target 36060143 hsa-mir-200a Stomach Neoplasms These results indicate that XTSJ may affect EMT and Bcl-2 signaling pathways by regulating lncRNA-ATB and miR-200a, thus inhibiting proliferation, migration, and invasion of HGC-27 cells. +epigenetics 36060016 hsa-mir-18a Colorectal Neoplasms The aim of this study was to establish whether there is a relationship between the expression of the wild-type KRAS gene, the methylation status of its distal promoter, and miR-143 and miR-18a-3p levels in samples of sporadic CRC. +epigenetics 36060016 hsa-mir-143 Colorectal Neoplasms The aim of this study was to establish whether there is a relationship between the expression of the wild-type KRAS gene, the methylation status of its distal promoter, and miR-143 and miR-18a-3p levels in samples of sporadic CRC. +genetics_knock down_suppress 36059820 hsa-mir-146a Chronic Kidney Disease Furthermore, induction of hyperglycemia using streptozotocin (STZ) also resulted in an accelerated development of glomerulopathy and a rapid increase in proteinuria in the knockout animals, as compared to the WT animals, further confirming the protective role of podocyte-expressed miR-146a. +genetics_knock down_suppress 36059820 hsa-mir-146 Chronic Kidney Disease Furthermore, induction of hyperglycemia using streptozotocin (STZ) also resulted in an accelerated development of glomerulopathy and a rapid increase in proteinuria in the knockout animals, as compared to the WT animals, further confirming the protective role of podocyte-expressed miR-146a. +target gene 36059813 hsa-mir-145 Breast Neoplasms CircEPSTI1 Promotes the Proliferation of HER2-Positive Breast Cancer Cells via circEPSTI1/miR-145/ERBB3 Axis. +genetics_knock down_promote 36059806 hsa-mir-485 Pancreatic Carcinoma We confirmed that circLMTK2 knockdown attenuated GEM-resistant PC cells by regulating PAK1 via miR +genetics_knock down_promote 36059797 hsa-mir-299 Nasopharyngeal Carcinoma Overexpression of MMP-2 substantially reduced the miR +target gene 36059697 hsa-mir-1 Prostatic Neoplasms miR-31-3p functions as a tumor suppressor by directly targeting GABBR2 in prostate cancer. +other 36059695 hsa-mir-124 Lymphoma, T-Cell, Cutaneous Our study provides a rationale for further studies focused on an evaluation of MALAT1-miR-124 in CTCL progression. +lncRNA target 36059662 hsa-mir-186 Adenocarcinoma of Lung METHODS: Regarding the public databases and based on integrating bioinformatics analyses, we determined whether LncRNA-AC009948.5 exerts its oncogenic functions via sponging miR5p in LUAD. +other 36059626 hsa-mir-186 Osteosarcoma Mechanism studies revealed that circ0038632 sponged miR-186 to upregulate the expression of DNA methyltransferase 3A (DNMT3A) to promote osteosarcoma progression. The circ0038632/miR-186/DNMT3A axis was involved in osteosarcoma progression. +transcription factor target 36059036 hsa-mir-124 Autism Spectrum Disorder This study revealed an unanticipated role of the miR-124/Nr4a1 signaling in regulating early social experience-dependent mPFC myelination, which may serve as a potential therapy target for social neglect or social isolation-related neuropsychiatric disorders. +lncRNA target 36058969 hsa-mir-429 Breast Neoplasms In breast cancer, the levels of oncogenic microRNA (miR-21, miR-221, and miR-27a) were increased, while the level of tumor-suppressing miR-429 was reduced in comparison with the intact group. The level of tumor-suppressing miR-429 in breast tumor tissues remained reduced, as in the untreated breast cancer group. +target gene 36058922 hsa-mir-877 Leukemia, Myelogenous, Chronic, BCR-ABL Positive circCRKL, a circRNA derived from CRKL, regulates BCR-ABL via sponging miR-877-5p to promote chronic myeloid leukemia cell proliferation. +transcription factor target 36058441 hsa-mir-21 Heart Diseases CONCLUSION: In human cardiomyocytes, the abundance of miRNA-21 takes part in first defense mechanism against cardiac insult and its cardioprotective effect depends on time of exposure to injury. +transcription factor target 36058294 hsa-mir-34a Diabetes Mellitus Our findings highlight a critical role of miR-34a-5p in the regulation of hepatic gluconeogenesis and miR-34a-5p may be a potential target in the treatment of type 2 diabetes. +transcription factor target 36058294 hsa-mir-34a Diabetes Mellitus, Type 2 Our findings highlight a critical role of miR-34a-5p in the regulation of hepatic gluconeogenesis and miR-34a-5p may be a potential target in the treatment of type 2 diabetes. +lncRNA target 36058131 hsa-mir-376a Adenocarcinoma of Lung The interactions between TRIM36, RAD1 and hsa-miR-376a-5p can be future therapeutic targets to increase radiation sensitivity in LUAD patients. +other 36058014 hsa-mir-129 Thyroid Cancer, Papillary Circ_0027446 induces CLDN1 expression to promote papillary thyroid cancer cell malignancy by binding to miR-129-5p. +genetics_knock down_suppress 36057400 hsa-mir-6918 Reperfusion Injury 5p enhanced the ischemic AKI; this was diminished by MBD2-KO. +lncRNA target 36057399 hsa-mir-376b Non-alcoholic Fatty Liver Disease Thus, miR-376b-3p may serve as a potential diagnostic marker or therapeutic target for NAFLD. +lncRNA target 36057384 hsa-mir-1303 Tuberculosis 3p down-regulation and miR-1303 up-regulation accompanied with corresponding changes in their predicted target genes in an independent validation cohort of 46 active TB patients, 30 latent TB infection subjects, and 24 non-infected healthy subjects. +lncRNA target 36057384 hsa-mir-431 Tuberculosis 3p down-regulation and miR-1303 up-regulation accompanied with corresponding changes in their predicted target genes in an independent validation cohort of 46 active TB patients, 30 latent TB infection subjects, and 24 non-infected healthy subjects. +circulation_biomarker_diagnosis_up 36057114 hsa-mir-1 Azoospermia The use of total seminal plasma as an analytical sample would facilitate the use of a simplified technical procedure for miR +transcription factor target 36057111 hsa-mir-34 Autographa californica multiple nuclear polyhedrosis virus frugiperda in the anti-Autographa californica multiple nucleopolyhedrovirus (AcMNPV), providing a reference for the design of a miR5p target biopesticide against S. +genetics_knock down_promote 36056852 hsa-mir-1260b Breast Neoplasms Knockdown of miR-1260b significantly suppressed breast cancer cell migration and invasion and yielded the opposite result. +circRNA target 36056804 hsa-mir-1182 Carcinoma, Non-Small-Cell Lung Moreover, TFAM was targeted by miR-1182, and miR-1182 hindered NSCLC cell progression by regulating TFAM. Additionally, circ_0002476 silencing could reduce NSCLC tumor growth by miR-1182/TFAM. +lncRNA target 36056431 hsa-mir-185 Uterine Cervical Neoplasms 5p/RSF-1 modulates cisplatin resistance and angiogenesis through AKT1/GSK3beta/VEGFA pathway in cervical cancer. +target gene 36056285 hsa-mir-761 Ovarian Neoplasms Circ_0061140 Contributes to Ovarian Cancer Progression by Targeting miR-761/LETM1 Signaling. +other 36054706 hsa-mir-26b Chronic Periodontitis MATERIALS AND METHODS: Expression of miR-26a-5p and miR-26b-5p was quantified in gingival biopsies derived from healthy and periodontally diseased subjects before and after non-surgical (scaling and root planing) therapy by RT-qPCR. +other 36054706 hsa-mir-26a Chronic Periodontitis CONCLUSIONS: Downregulated miR-26a-5p levels in periodontal inflammation may interfere with key cellular functions that may have significant implications for host defence and wound healing. +lncRNA target 36054700 hsa-mir-216a Uterine Cervical Neoplasms Whereas, transfection of miR-216a-3p inhibitor partially reverses the above cellular activities changes in cervical cancer cells. +genetics_overexpression_promote 36054559 hsa-mir-128 Carcinoma, Non-Small-Cell Lung 3p overexpression-induced apoptosis and autophagy inhibition in NSCLC by increasing the phosphorylation of JAK2 and STAT3. +circulation_biomarker_diagnosis_ns 36054529 hsa-mir-142 Diabetes Mellitus, Type 2 5p as a potential biomarker of the presence of MAFLD in preadolescent children while circulating miR-320a, miR +circulation_biomarker_diagnosis_ns 36054529 hsa-let-7 Diabetes Mellitus, Type 2 5p as a potential biomarker of the presence of MAFLD in preadolescent children while circulating miR-320a, miR +other 36054529 hsa-mir-4791 Diabetes Mellitus, Type 2 In addition, children with IR showed higher levels of miR-374a-5p and miR-190a-5p (p<0.01) and lower levels of miR-4284 and miR-4791 (p<005), than their peers without IR in both the whole sample and in those with overweight or obesity. +circulation_biomarker_diagnosis_ns 36054529 hsa-mir-142 Metabolic Associated Fatty Liver Disease 5p as a potential biomarker of the presence of MAFLD in preadolescent children while circulating miR-320a, miR +circulation_biomarker_diagnosis_ns 36054529 hsa-mir-190a Diabetes Mellitus, Type 2 5p as a potential biomarker of the presence of MAFLD in preadolescent children while circulating miR-320a, miR +circulation_biomarker_diagnosis_ns 36054529 hsa-mir-190a Metabolic Associated Fatty Liver Disease 5p as a potential biomarker of the presence of MAFLD in preadolescent children while circulating miR-320a, miR +circulation_biomarker_diagnosis_ns 36054529 hsa-mir-374a Diabetes Mellitus, Type 2 5p as a potential biomarker of the presence of MAFLD in preadolescent children while circulating miR-320a, miR +circulation_biomarker_diagnosis_ns 36054529 hsa-mir-20a Metabolic Associated Fatty Liver Disease 5p as a potential biomarker of the presence of MAFLD in preadolescent children while circulating miR-320a, miR +circulation_biomarker_diagnosis_ns 36054529 hsa-mir-374a Metabolic Associated Fatty Liver Disease 5p as a potential biomarker of the presence of MAFLD in preadolescent children while circulating miR-320a, miR +circulation_biomarker_diagnosis_ns 36054529 hsa-mir-20a Diabetes Mellitus, Type 2 5p as a potential biomarker of the presence of MAFLD in preadolescent children while circulating miR-320a, miR +circulation_biomarker_diagnosis_ns 36054529 hsa-mir-660 Metabolic Associated Fatty Liver Disease 5p as a potential biomarker of the presence of MAFLD in preadolescent children while circulating miR-320a, miR +other 36054529 hsa-mir-4791 Metabolic Associated Fatty Liver Disease In addition, children with IR showed higher levels of miR-374a-5p and miR-190a-5p (p<0.01) and lower levels of miR-4284 and miR-4791 (p<005), than their peers without IR in both the whole sample and in those with overweight or obesity. +circulation_biomarker_diagnosis_ns 36054529 hsa-let-7 Metabolic Associated Fatty Liver Disease 5p as a potential biomarker of the presence of MAFLD in preadolescent children while circulating miR-320a, miR +other 36054529 hsa-mir-4284 Metabolic Associated Fatty Liver Disease In addition, children with IR showed higher levels of miR-374a-5p and miR-190a-5p (p<0.01) and lower levels of miR-4284 and miR-4791 (p<005), than their peers without IR in both the whole sample and in those with overweight or obesity. +other 36054529 hsa-mir-4284 Diabetes Mellitus, Type 2 In addition, children with IR showed higher levels of miR-374a-5p and miR-190a-5p (p<0.01) and lower levels of miR-4284 and miR-4791 (p<005), than their peers without IR in both the whole sample and in those with overweight or obesity. +circulation_biomarker_diagnosis_ns 36054529 hsa-mir-660 Diabetes Mellitus, Type 2 5p as a potential biomarker of the presence of MAFLD in preadolescent children while circulating miR-320a, miR +genetics_knock down_promote 36054164 hsa-mir-942 Breast Neoplasms 5p overexpression reversed the influence of circ_RNF10 overexpression on BC progression. +exosome 36053959 hsa-mir-1224 Osteopenic Nonfracture Syndrome The analysis of miRNome revealed that miR-1246 and miR5p were the most upregulated and downregulated in OP EVs; the modulated EV-miRNAs in OP and OPN compared to CN are related to osteoclast differentiation, interleukin-13 production and regulation of canonical WNT pathway. +exosome 36053959 hsa-mir-1224 Osteoporosis The analysis of miRNome revealed that miR-1246 and miR5p were the most upregulated and downregulated in OP EVs; the modulated EV-miRNAs in OP and OPN compared to CN are related to osteoclast differentiation, interleukin-13 production and regulation of canonical WNT pathway. +genetics_knock down_suppress 36053930 hsa-mir-4282 Breast Neoplasms LINC00536 knockdown inhibits breast cancer cells proliferation, invasion, and migration through regulation of the miR-4282/centromere protein F axis. +lncRNA target 36053456 hsa-mir-149 Adrenal Cortex Neoplasms 3p promotes H295A cell viability by downregulating CDKN1A and provide evidence that miR +genetics_overexpression_promote 36053263 hsa-mir-192 Hepatitis B 5p inhibitor-transfected group exhibited the opposite results, and ATG7 overexpression reversed the effects of miR +circulation_biomarker_diagnosis_up 36053124 hsa-mir-515 Prostatic Neoplasms Plasmacytoma variant translocation 1 inhibits miR-515-5p function and modulates high mobility group B3 to promote the growth of prostate cancer cells. +tissue_expression_ns 36052916 hsa-mir-222 Carotid Stenosis The ROC, Kaplan-Meier, and Cox regression analyses were carried out to estimate the diagnostic and prognostic value of GAS5 and miR +genetics_knock down_suppress 36052886 hsa-mir-335 Acute Kidney Injury Circ-ZNF644 knockdown relieved LPS-induced HK2 cell injury through the miR +genetics_knock down_suppress 36052886 hsa-mir-335 Sepsis Circ-ZNF644 knockdown relieved LPS-induced HK2 cell injury through the miR +lncRNA target 36052873 hsa-mir-216a Inflammation CONCLUSIONS: TG protects chondrocytes against IL-1beta-induced inflammation and apoptosis via miR-216a-5p/TLR4/NF-kappaB axis. +genetics_knock down_suppress 36052865 hsa-mir-363 familial febrile seizures 1 Furthermore, PDCD6IP knockdown imitated, while overexpression reversed the effects of miR3633p overexpression on OGD/Rinduced cell injury. +genetics_overexpression_promote 36052751 hsa-mir-10b Glioma The macrophages or glioma cells were transfected with overexpressing plasmid or shRNA to study the effects of miR-10b-5p/NEDD4L/PIK3CA on M2 macrophage polarization, and glioma cell proliferation, migration, and invasion in vitro and in vivo. +other 36052691 hsa-mir-342 Pancreatitis ASAP1-IT2/DGCR9-hsa-miR5p-ABCC5/MAP2K6 was the only one specific interaction pair identified in ARP. +other 36052236 hsa-mir-532 Carcinoma, Renal Cell In conclusion, our study identified the PVT1/SNHG15-hsa-miR3p-PLAUR axis and a prognostic signature of PRIs, which could be a reference for future clinical research. +other 36051820 hsa-mir-29c Nephritis, Interstitial miR-29c, which is an antifibrotic microRNA, downregulates renal interstitial fibrosis by downregulating the TGF-beta and collagen. +genetics_overexpression_promote 36050752 hsa-mir-338 Arthritis, Rheumatoid Silencing of NEAT1 and overexpression of miR +lncRNA target 36050724 hsa-mir-143 Triple Negative Breast Neoplasms mediated inhibition of glycolysis for reversing GEM resistance in TNBC. +other 36050647 hsa-mir-202 Migraine Disorders 5p. +other 36050647 hsa-mir-7855 Migraine Disorders 5p. +other 36050647 hsa-mir-1538 Migraine Disorders 5p. +other 36050647 hsa-mir-6770 Migraine Disorders 5p. +other 36050647 hsa-mir-409 Migraine Disorders 5p. +other 36050615 hsa-mir-198 Carcinoma, Hepatocellular Previous screening on patient specimens identified miR-198 as the most downregulated miRNA in HCC. +lncRNA target 36049539 hsa-mir-885 Lupus Erythematosus, Cutaneous 5p in CLE KCs, leading to epidermal inflammation by NF-kappaB activity enhancement and proliferation through PSMB5 and immune recruitment through TRAF1. +other 36049464 hsa-mir-26a Neural Tube Defects The present study aimed to explore the potential role of miRNA-26a in NTDs and the underlying pathogenesis thereof. First, we found significantly increased miRNA-26a expression in fetuses with NTDs (p < 0.0001), which significantly downregulated EphA2 and ERK1 mRNA and protein expression levels in fetuses with NTDs compared to normal controls (p < 0.01). +target gene 36049358 hsa-mir-204 Breast Neoplasms Circular RNA circMET contributes to tamoxifen resistance of breast cancer cells by targeting miR-204/AHR signaling. +circulation_biomarker_diagnosis_ns 36048908 hsa-mir-24 Cardiovascular Diseases CONCLUSION: Plasmatic expression of microRNA-24, 96, 103, 125a, 132, 146, 191, 223 and Let7a were associated with surrogate markers of CV disease and could be predictors of CV risk in patients with RA. +circulation_biomarker_diagnosis_ns 36048908 hsa-let-7a Arthritis, Rheumatoid CONCLUSION: Plasmatic expression of microRNA-24, 96, 103, 125a, 132, 146, 191, 223 and Let7a were associated with surrogate markers of CV disease and could be predictors of CV risk in patients with RA. +circulation_biomarker_diagnosis_ns 36048908 hsa-mir-24 Arthritis, Rheumatoid CONCLUSION: Plasmatic expression of microRNA-24, 96, 103, 125a, 132, 146, 191, 223 and Let7a were associated with surrogate markers of CV disease and could be predictors of CV risk in patients with RA. +circulation_biomarker_diagnosis_ns 36048908 hsa-let-7a Cardiovascular Diseases CONCLUSION: Plasmatic expression of microRNA-24, 96, 103, 125a, 132, 146, 191, 223 and Let7a were associated with surrogate markers of CV disease and could be predictors of CV risk in patients with RA. +other 36048381 hsa-mir-206 Pre-Eclampsia miR-206 and miR-30a play a role by regulating CD39 and CD73 as molecules that are involved in ATP catabolism as well as regulating the production of IGF-1 in the process of hypertension, which is the main feature in patients with preeclampsia. +other 36048381 hsa-mir-18a Pre-Eclampsia On the other hand, decreased level of miR-18a lead to upregulation of HIF-1a, and the consequence condition of hypoxia increases hypertension and inflammation in these patients. +transcription factor target 36047894 hsa-mir-23a Aortic Aneurysm, Abdominal Our findings suggest that miRNA-323a-3p targeting AdipoR1 is promising in further anti-inflammatory treatment of IAs. +circulation_biomarker_diagnosis_ns 36047533 hsa-mir-101 Diabetes, Gestational CONCLUSION: Serum miR-101 level may be a biomarker for grading HDCP. +other 36047424 hsa-mir-181b Urinary Bladder Neoplasms 3p. +other 36047424 hsa-mir-221 Urinary Bladder Neoplasms 3p. +exosome 36046998 hsa-mir-374 Spinal Cord Injuries 5p in neuronal exosomes could enhance spinal cord injury recovery by activating autophagy. +lncRNA target 36046997 hsa-mir-204 Osteoporosis OBJECTIVE: To explore the regulation of LncRNA TUG /miRNA-204/SIRT1 pathway on osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), so as to provide a new theoretical basis for the clinical treatment of osteoporosis. CONCLUSION: This study found the direct regulatory relationship of LncRNA TUG/miR-204/SIRT1 during the osteogenic differentiation of BMSCs, and revealed that SIRT1 positively regulates the osteogenic differentiation of BMSCs, which provides a theoretical basis and potential therapeutic targets for a series of osteogenic differentiation-related diseases including osteoporosis. +genetics_knock down_promote 36046641 hsa-let-7c Adenocarcinoma of Lung Results: Finally, circRNA_0039908/let7c-5p/RRM2 axis was identified in our research, it can play an important role in the LUAD pathogenesis progression and we found that the proliferation, invasion and migration abilities of LUAD cells can be suppressed after knockdown of circRNA_0039908. This work indicates that circRNA_0039908/let7c-5p/RRM2 axis may be a promising target in the prognosis and treatment of LUAD patients. +target gene 36046633 hsa-mir-2052 Breast Neoplasms LncRNA LINC01857 reduces metastasis and angiogenesis in breast cancer cells via regulating miR-2052/CENPQ axis. +genetics_knock down_promote 36046536 hsa-mir-145 Neoplasm Metastasis Overexpression of MEG3 was able to decrease miR-145 level and NEDD9 protein level in Cr(VI)-transformed cells. +transcription factor target 36046375 hsa-mir-381 Carcinoma, Non-Small-Cell Lung miR-381 Inhibits Proliferation and Invasion of Non-Small-Cell Cancer Cells by It is known that miR-381 plays a therapeutic role in a variety of cancers, but the regulatory mechanism of miR-381 in the treatment of lung cancer remains unclear. miR-381 was downregulated in non-small-cell lung cancer tissues and cell lines, while USP39 was upregulated. +genetics_overexpression_suppress 36046374 hsa-mir-33a Stomach Neoplasms Overexpression of miR-33a-5p in BGC-823 and MGC-803 cells greatly inhibited the cell invasion and colony number. +exosome 36045954 hsa-mir-100 Wounds and Injuries miR5p-enriched ADSC-Exos can be used to treat skin wound and expand EpSCs for generating epidermal autografts and engineered skin equivalents. +lncRNA target 36045666 hsa-let-7c Pre-Eclampsia CONCLUSIONS: The hsa-let-7c/IGF1R axis might affect the PI3K-Akt signaling pathway which is involved in the pathogenesis of PE, and inhibitors targeting this pathway might be used for PE treatment. +lncRNA target 36045665 hsa-mir-144 Glioma TMP inhibits the proliferation, migration, and invasion of glioma cells by regulating the UBL7-AS1/miR +lncRNA target 36045598 hsa-mir-122 Lung Neoplasms Reduced linc01555 refrained tumor growth and DDP resistance in vivo.In short, linc01555 may cause changes in DDP resistance via miR +lncRNA target 36045598 hsa-mir-122 Infant, Small For Gestational Age Reduced linc01555 refrained tumor growth and DDP resistance in vivo.In short, linc01555 may cause changes in DDP resistance via miR +lncRNA target 36045408 hsa-mir-1322 Prostatic Neoplasms CONCLUSIONS: CircSMARCC1 up-regulates the chemokine CCL20 secretion by sponging miR-1322, which is involved in the crosstalk between tumor cells and TAMs by targeting CCL20/CCR6 signaling to promote progression of PCa. +lncRNA target 36045396 hsa-mir-547 Neuralgia MiR3p may be a key target of MT for anti-inflammatory and analgesia effects, which is achieved by mediating the Map4k4/NF-kappaB pathway to regulate downstream inflammatory cytokines. +lncRNA target 36045117 hsa-mir-145 Urinary Bladder Neoplasms These findings not only provide a novel insight into the understanding association of autophagy induction with BC invasion inhibition by ISO, but also identify an upstream regulatory cascade, Dicer/miR145/SOX2/miR365a/RAC1, leading to MKK7/JNKs activation and autophagy induction. +lncRNA target 36045117 hsa-mir-365a Urinary Bladder Neoplasms These findings not only provide a novel insight into the understanding association of autophagy induction with BC invasion inhibition by ISO, but also identify an upstream regulatory cascade, Dicer/miR145/SOX2/miR365a/RAC1, leading to MKK7/JNKs activation and autophagy induction. +circulation_biomarker_diagnosis_down 36043754 hsa-mir-146 COVID-19 CONCLUSION: High viral load, increased blood level of ACE2, and down-regulation of micro-RNA 146 expression are associated with more severe lung injury and the presence of neurologic complications like convulsions and coma in COVID-19 Egyptian patients. +circulation_biomarker_diagnosis_ns 36043408 hsa-mir-106a Multiple Sclerosis RESULTS: The expression levels of miR-330, miR-106a, and miR125-b in blood samples of RRMS patients were predominantly reduced. +circulation_biomarker_diagnosis_ns 36043408 hsa-mir-30 Multiple Sclerosis RESULTS: The expression levels of miR-330, miR-106a, and miR125-b in blood samples of RRMS patients were predominantly reduced. +other 36043408 hsa-mir-125b Multiple Sclerosis This study aimed to evaluate the miR-106a, miR-125b, and miR330- expression levels in relapsing-remitting multiple sclerosis (RRMS) patients. +transcription factor target 36043333 hsa-mir-454 Reperfusion Injury, Cerebral Ischemia MiR-454 protected animals from brain injury induced by cerebral I/R via directly regulating its target gene NOX4, illustrating a curatively potential target for treating ischemic stroke. +lncRNA target 36043264 hsa-mir-204 Corneal Neovascularization MiR-204 may be a potential therapeutic target in alkali burn-induced CNV. +circulation_biomarker_diagnosis_ns 36043143 hsa-mir-424 Carcinoma, Non-Small-Cell Lung Furthermore, the predictive value of the P53 protein gene on the occurrence of BMS in NSCLC is analyzed by the ROC curve, and the expression of miR-424 in serum of the patients before and after drug resistance is compared. +exosome 36043050 hsa-mir-581 Gallbladder Neoplasms Through a three-step study that relies on biomarker discovery, training, and validation, we identified a set of five exosomal microRNAs (miRNAs) that can be used to evaluate the risk of gallbladder carcinoma (GBC), including miR3p, miR-581, miR-4433a-3p, miR-496, and miR-203b-3p. +exosome 36043050 hsa-mir-4433a Gallbladder Neoplasms Through a three-step study that relies on biomarker discovery, training, and validation, we identified a set of five exosomal microRNAs (miRNAs) that can be used to evaluate the risk of gallbladder carcinoma (GBC), including miR3p, miR-581, miR-4433a-3p, miR-496, and miR-203b-3p. +exosome 36043050 hsa-mir-203b Gallbladder Neoplasms Through a three-step study that relies on biomarker discovery, training, and validation, we identified a set of five exosomal microRNAs (miRNAs) that can be used to evaluate the risk of gallbladder carcinoma (GBC), including miR3p, miR-581, miR-4433a-3p, miR-496, and miR-203b-3p. +exosome 36043050 hsa-mir-552 Gallbladder Neoplasms Through a three-step study that relies on biomarker discovery, training, and validation, we identified a set of five exosomal microRNAs (miRNAs) that can be used to evaluate the risk of gallbladder carcinoma (GBC), including miR3p, miR-581, miR-4433a-3p, miR-496, and miR-203b-3p. +exosome 36043050 hsa-mir-496 Gallbladder Neoplasms Through a three-step study that relies on biomarker discovery, training, and validation, we identified a set of five exosomal microRNAs (miRNAs) that can be used to evaluate the risk of gallbladder carcinoma (GBC), including miR3p, miR-581, miR-4433a-3p, miR-496, and miR-203b-3p. +other 36042613 hsa-mir-613 Atrial Fibrillation 3p-CXCR4 regulatory axis may be associated with the pathogenesis of AF. +other 36042613 hsa-mir-1207 Atrial Fibrillation 3p-CXCR4 regulatory axis may be associated with the pathogenesis of AF. +circulation_biomarker_diagnosis_up 36042375 hsa-mir-375 Prostatic Neoplasms, Castration-Resistant Previously, we found that plasma exosomal miR-375 is significantly elevated in castration-resistant PCa (CRPC) patients compared with castration-sensitive PCa patients. +other 36042288 hsa-mir-133a Disease Our results suggest that controlled delivery of miR-133a-3p mimics, or antagomirs in diseased endothelial cells, might open new therapeutic interventions to treat patients suffering from cardiovascular pathologies that occur with excessive or insufficient angiogenesis. +other 36042288 hsa-mir-133a Cardiovascular Diseases Our results suggest that controlled delivery of miR-133a-3p mimics, or antagomirs in diseased endothelial cells, might open new therapeutic interventions to treat patients suffering from cardiovascular pathologies that occur with excessive or insufficient angiogenesis. +other 36042287 hsa-mir-573 Breast Neoplasms LINC00511/hsa-miR-573 axis-mediated high expression of Gasdermin C associates Breast cancer (BC) is considered the second commonest human carcinoma and the most incident and mortal in the female population. We finally identified LINC00511/hsa-miR-573 axis to be the most promising ncRNA-associated pathways that account for GSDMC in BRCA. +circRNA target 36042279 hsa-mir-4691 Urethral Stricture Our results showed that circ_0047339 might promote the growth and fibrosis of urethral scar fibroblasts through miR5p/TSP-1 axis, thus promoting the development of urethral stricture. +circulation_biomarker_diagnosis_ns 36041701 hsa-mir-15b familial multiple nevi flammei SIGNIFICANCE: Circulating PVT1 may serve as a useful biomarker to distinguish between good versus poor CCC, as it is involved in orchestrating angiogenesis via the miR-15b-5p-AKT3 axis; it thus has potential as a target for treating ischemic disease. +circulation_biomarker_diagnosis_ns 36041701 hsa-mir-15b Coronary Artery Disease SIGNIFICANCE: Circulating PVT1 may serve as a useful biomarker to distinguish between good versus poor CCC, as it is involved in orchestrating angiogenesis via the miR-15b-5p-AKT3 axis; it thus has potential as a target for treating ischemic disease. +lncRNA target 36041665 hsa-mir-217 Intervertebral Disc Degeneration Furthermore, in vivo experimental results confirmed the suppressive role of miR-217 shuttled by MSC-EVs in IVDD. +genetics_knock down_promote 36041411 hsa-mir-526b Uterine Cervical Neoplasms CONCLUSION: Circ_0002762 knockdown inhibited CC progression by regulating miR-526b-5p/HK2 axis, suggesting that circ_0002762 was a promising therapeutic strategy for CC. +lncRNA target 36041209 hsa-mir-154 Osteosarcoma FGD5-AS1 may promote chemoresistance through WNT5A-induced autophagy by sponging miR +other 36041072 hsa-mir-124 Breast Neoplasms These data suggest that a CPSF1-p62-miR3p signaling axis is responsible for reduced sensitivity of breast cancer to chemotherapy. +genetics_overexpression_promote 36040683 hsa-mir-25 Gastrointestinal Stromal Tumors 3p abrogated the tumor-initiating effects of METTL3 overexpression on GISTs. +lncRNA target 36040608 hsa-mir-146a Spinal Cord Injuries Overall, our findings initially highlighted that Nrf2 inhibited GSDMD-mediated microglia pyroptosis and accelerated SCI repair by repressing miR-146a. +lncRNA target 36040555 hsa-mir-185 Alzheimer Disease 5p was related to both education and depression, whose decreased expression pattern in AD patients was alleviated by education and enhanced by depression, and participates in Abeta generation and accumulation. +lncRNA target 36040387 hsa-mir-217 Inflammation 5p suppressed the activated STAT1-signal induced inflammation and oxidative stress trigged by PM2.5 in macrophages and resulted in the decreased lung injure caused by PM2.5. +other 36040381 hsa-mir-139 Breast Neoplasms Moreover, The AC026401.3/CCNB1-miR5p axis was discovered as the most promising upstream ncRNA-related pathway of CCNB1 in BC. +lncRNA target 36039935 hsa-mir-9 Uterine Cervical Neoplasms SOX21-AS1 was targeted by miR3p in CC cells. +genetics_overexpression_promote 36039933 hsa-mir-126 Squamous Cell Carcinoma of Head and Neck 5p mimic exerted suppressive functions in the progression of OSCC, which were neutralized after GAB1 overexpression. +lncRNA target 36039677 hsa-mir-99a Hepatolenticular Degeneration Furthermore, MR signaling also mediated WD/aldosterone-induced reductions in soleus microRNA (miR)-99a, which was identified to negatively target CD36 and prevented palmitic acid-induced increases in CD36 expression, lipid droplet formation, mitochondria dysfunction, and insulin resistance in C2C12 cells. +lncRNA target 36039677 hsa-mir-99a Muscular Atrophy Furthermore, MR signaling also mediated WD/aldosterone-induced reductions in soleus microRNA (miR)-99a, which was identified to negatively target CD36 and prevented palmitic acid-induced increases in CD36 expression, lipid droplet formation, mitochondria dysfunction, and insulin resistance in C2C12 cells. These data indicate that inhibition of MR activation with spironolactone prevented diet-induced abnormal expression of miR-99a, which had the capacity to reduce CD36, leading to reduced IMC lipid content and improved soleus mitochondria function and insulin sensitivity. +lncRNA target 36039677 hsa-mir-99a Mitochondrial Diseases Furthermore, MR signaling also mediated WD/aldosterone-induced reductions in soleus microRNA (miR)-99a, which was identified to negatively target CD36 and prevented palmitic acid-induced increases in CD36 expression, lipid droplet formation, mitochondria dysfunction, and insulin resistance in C2C12 cells. +lncRNA target 36039677 hsa-mir-99a Insulin Resistance Furthermore, MR signaling also mediated WD/aldosterone-induced reductions in soleus microRNA (miR)-99a, which was identified to negatively target CD36 and prevented palmitic acid-induced increases in CD36 expression, lipid droplet formation, mitochondria dysfunction, and insulin resistance in C2C12 cells. +lncRNA target 36039591 hsa-mir-21 Reperfusion Injury MiRNA-21 promotes or inhibits autophagy via regulating relevant pathways for different downstream target genes, and plays a role in tumors, ischemia-reperfusion injury, and other diseases. +lncRNA target 36039578 hsa-mir-143 Glioma miR-143 mimics and inhibitor were used to change the level of miR-143 in glioma cells. CONCLUSIONS: The up-regulated lncRNA SNHG14 can target miR-143, relieve the inhibition of miR-143 on MGMT, and promote the TMZ resistance in the hypoxia-induced glioma cells. +other 36039443 hsa-mir-5194 Stomach Neoplasms Thus, the aim of this study was to understand the possible impact of transcriptional alterations and copy number variation (CNV) of four genes located in the 8q24.21 region - FAM49B, FAM84B, GSDMC and miR-5194 - in GC. +other 36039421 hsa-mir-205 Breast Neoplasms 5p-based therapy may expand the therapeutic opportunities for breast cancer. +other 36039421 hsa-mir-205 Drug Hypersensitivity 5p-based therapy may expand the therapeutic opportunities for breast cancer. +lncRNA target 36039405 hsa-mir-21 Neuralgia These results indicated that Rh2 relieved SNI-induced neuropathic pain via inhibiting the miRNATLR8-MAPK signaling pathway, thus providing a potential application of Rh2 in pain therapy. +genetics_GWAS 36039054 hsa-mir-181b Leukemia, Myeloid, Acute In addition, miR-181b-5p expression was decreased in AML patients with the FLT3-ITD mutation (P=0.032) or WT1 mutation (P=0.017) when compared to AML patients without these genetic mutations. +other 36038907 hsa-mir-765 Carcinoma, Hepatocellular RESULTS: lncRNA-AC079061.1, hsa-miR-765, and VIPR1 were identified as independent factors that affect the prognosis of hepatocellular carcinoma. Experimental results suggested that lncRNA-AC079061.1 and VIPR1 were frequently downregulated in HCC cells, while hsa-miR-765 was significantly upregulated. +target gene 36038837 hsa-mir-659 Osteosarcoma MiR-659-3p inhibits osteosarcoma progression and metastasis by inhibiting cell proliferation and invasion via targeting SRPK1. +transcription factor target 36038535 hsa-mir-195 Alzheimer Disease 5p in AD pathogenesis and highlight several novel potentially relevant target mRNAs. +other 36037122 hsa-mir-130b Carcinoma, Hepatocellular RESULTS: miR-130b was significantly upregulated, whereas miR-125b was significantly downregulated in HCC patients compared with cirrhotic patients and healthy controls. +circulation_biomarker_diagnosis_up 36037122 hsa-mir-125b Carcinoma, Hepatocellular CONCLUSION: Plasma miR-130b and miR-125b may play a role in disease progression and development of HCC and may act as potential biomarkers for the diagnosis of HCC. +other 36037113 hsa-mir-133a Uterine Neoplasms This study aimed to elucidate whether some specific types of miRNAs (miRNA133-a, miRNA-21, miRNA-205) can act as prognostic or diagnostic biomarkers for endometrial carcinoma (ER) in Egyptian patients. +circulation_biomarker_prognosis_up 36037113 hsa-mir-205 Uterine Neoplasms CONCLUSION: The findings could support the use of circulating miR133a-2, miR-21 and miR-205 as virtuous prognostic biomarkers for EC in Egyptian patients. +circulation_biomarker_prognosis_up 36037113 hsa-mir-133a-2 Uterine Neoplasms CONCLUSION: The findings could support the use of circulating miR133a-2, miR-21 and miR-205 as virtuous prognostic biomarkers for EC in Egyptian patients. +circulation_biomarker_prognosis_up 36037113 hsa-mir-21 Uterine Neoplasms CONCLUSION: The findings could support the use of circulating miR133a-2, miR-21 and miR-205 as virtuous prognostic biomarkers for EC in Egyptian patients. +genetics_knock down_suppress 36036334 hsa-mir-188 Keloid GNAS-AS1 knockdown could regulate the miR +circRNA target 36036266 hsa-mir-197 Carcinoma, Non-Small-Cell Lung This work clarified the biological functions and molecular mechanisms of how hsa_circ_0003497 suppresses NSCLC through miR +lncRNA target 36035369 hsa-mir-21 Carcinoma, Renal Cell Conclusions: Hsa-mir-21 predicted target genes (RP2, NFIA, SPRY1 and TGFBI) and the common transcription factor ZNF263 could be the advanced prognosis biomarkers in KIRC patients. +circRNA target 36035287 hsa-mir-589 Diabetic Retinopathy 5p targeted YAP1 and relieved HG-induced cell dysfunction via downregulating YAP1. +other 36035214 hsa-mir-181b Atherosclerosis 3p) that were consistent with deep sequencing analysis suggesting a promising potential of utility to serve as diagnostic biomarkers against AS. +other 36035214 hsa-mir-350 Atherosclerosis 3p) that were consistent with deep sequencing analysis suggesting a promising potential of utility to serve as diagnostic biomarkers against AS. +other 36035214 hsa-mir-421 Atherosclerosis 3p) that were consistent with deep sequencing analysis suggesting a promising potential of utility to serve as diagnostic biomarkers against AS. +lncRNA target 36035170 hsa-mir-1224 Lumbosacral Spinal Root Avulsion Functional analyses based on gene ontology and Kyoto Encyclopedia of Genes and Genomes predicted the potential roles of differentially expressed circRNAs and mRNAs in LSRA, and circRNA/miRNA/mRNA interaction networks revealed that circRNA_7025, a down-regulated circRNA in LSRA, was targeted by two neuronal apoptosis-related miRNAs, rno-miR-1224 and rno-miR5p. +circulation_biomarker_diagnosis_up 36035156 hsa-mir-1 Heart Septal Defects, Ventricular 3p upregulation in circulation is a direct and powerful indicator of fetal VSD and is expected to serve as a prenatal VSD diagnostic marker. +circulation_biomarker_diagnosis_up 36035154 hsa-mir-6785 psoriasis 1 Serum EVs miR-1305 and miR +circulation_biomarker_diagnosis_up 36035154 hsa-mir-1305 psoriasis 1 Serum EVs miR-1305 and miR +other 36035012 hsa-mir-4429 Rectal Prolapse It was confirmed that miR-4429 interacted with PTEN messenger RNA (mRNA), and the expression level of miR-4429 was reduced in fibroblasts from the POP group or fibroblasts treated with AGEs. CONCLUSIONS: We proposed that AGEs induced fibroblast apoptosis by regulating the miR-4429/PTEN/PI3K/Akt pathway in POP. +other 36034978 hsa-mir-136 Osteosarcoma CONCLUSIONS: The lncRNA CRNDE promotes the proliferation and migration of OS cells by regulating the miR5p/MRP9 pathway, and lncRNA CRNDE can be a significant marker of OS prognosis. +exosome 36034465 hsa-mir-129b Femur Head Necrosis CONCLUSIONS: MQEF can regulate exosomal miRNA expression in steroid-induced INFH models, miR3p or miR-129b-5p/PI3K-Akt signal axis may be part of the mechanism of MQEF against steroid-induced INFH. +exosome 36034465 hsa-mir-185 Femur Head Necrosis CONCLUSIONS: MQEF can regulate exosomal miRNA expression in steroid-induced INFH models, miR3p or miR-129b-5p/PI3K-Akt signal axis may be part of the mechanism of MQEF against steroid-induced INFH. +other 36033831 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck 3p as the biomarker of oral cancer and established the miRNA-mRNA network in oral progression. +other 36033831 hsa-mir-15b Squamous Cell Carcinoma of Head and Neck 3p as the biomarker of oral cancer and established the miRNA-mRNA network in oral progression. +other 36033831 hsa-mir-199a Squamous Cell Carcinoma of Head and Neck 3p as the biomarker of oral cancer and established the miRNA-mRNA network in oral progression. +other 36033831 hsa-mir-424 Squamous Cell Carcinoma of Head and Neck 3p as the biomarker of oral cancer and established the miRNA-mRNA network in oral progression. +other 36033831 hsa-mir-454 Squamous Cell Carcinoma of Head and Neck 3p as the biomarker of oral cancer and established the miRNA-mRNA network in oral progression. +genetics_overexpression_promote 36033827 hsa-mir-657 Carcinoma, Non-Small-Cell Lung High levels of miR-657 were predictive of a poorer NSCLC patient prognosis, and overexpressing miR-657 resulted in the more rapid growth of NCI-H1650 and A549 cells, with a concomitant increase in their invasion. +other 36033494 hsa-mir-139 Adenocarcinoma of Lung Furthermore, a miRNA panel for early LUAD composed of miR4732-5p, miR451a, miR486-5p, and miR139-3p was defined with an AUC of 0.8554 at 91.07% sensitivity and 66.36% specificity. +other 36033494 hsa-mir-486 Adenocarcinoma of Lung Furthermore, a miRNA panel for early LUAD composed of miR4732-5p, miR451a, miR486-5p, and miR139-3p was defined with an AUC of 0.8554 at 91.07% sensitivity and 66.36% specificity. +other 36033494 hsa-mir-4732 Adenocarcinoma of Lung Furthermore, a miRNA panel for early LUAD composed of miR4732-5p, miR451a, miR486-5p, and miR139-3p was defined with an AUC of 0.8554 at 91.07% sensitivity and 66.36% specificity. +other 36033494 hsa-mir-451a Adenocarcinoma of Lung Furthermore, a miRNA panel for early LUAD composed of miR4732-5p, miR451a, miR486-5p, and miR139-3p was defined with an AUC of 0.8554 at 91.07% sensitivity and 66.36% specificity. +lncRNA target 36033389 hsa-mir-146b Breast Neoplasms Therefore, we conclude that MEG3 positively modulates SLFN5 expression by sponging miR-146b-5p and inhibits breast cancer development. +lncRNA target 36033309 hsa-mir-342 Squamous Cell Carcinoma of Head and Neck Finally, the results of in vivo models confirmed that SNHG20 promotes LSCC progression through modulating miR +lncRNA target 36032725 hsa-mir-21 Lung Neoplasms Through the detection of miRNA-21, healthy people and lung cancer patients were distinguished, which verified the possibility of the application in clinical detection. +lncRNA target 36032150 hsa-mir-616 Melanoma Through bioinformatics analysis, the OIP5-AS1-hsa-miR +lncRNA target 36032150 hsa-mir-23b Melanoma Through bioinformatics analysis, the OIP5-AS1-hsa-miR +lncRNA target 36032150 hsa-mir-374b Melanoma Through bioinformatics analysis, the OIP5-AS1-hsa-miR +lncRNA target 36032150 hsa-mir-135a Melanoma Through bioinformatics analysis, the OIP5-AS1-hsa-miR +lncRNA target 36032150 hsa-mir-186 Melanoma Through bioinformatics analysis, the OIP5-AS1-hsa-miR +other 36032099 hsa-mir-451a Acquired Immunodeficiency Syndrome 5p with the RPs. +other 36032099 hsa-mir-625 Acquired Immunodeficiency Syndrome 5p with the RPs. +other 36032099 hsa-mir-1180 Acquired Immunodeficiency Syndrome 5p with the RPs. +other 36032099 hsa-mir-62 Acquired Immunodeficiency Syndrome 5p with the RPs. +other 36032099 hsa-mir-144 Acquired Immunodeficiency Syndrome 5p with the RPs. +genetics_knock down_suppress 36030691 hsa-mir-326 Lung Diseases CONCLUSION: CircESPL1 knockdown might attenuate LPS-caused lung cell injury by regulating the miR-326/ MAPK14 axis, providing useful insight for exploring a novel therapeutic approach for IP. +transcription factor target 36030655 hsa-mir-382 Depression, Postpartum In conclusion, FN stimulation increases the expression of BDNF via down-regulating the expression of miR-382/miR-182, thus exhibiting a positive effect in the management of PSD. +transcription factor target 36030655 hsa-mir-182 Depression, Postpartum In conclusion, FN stimulation increases the expression of BDNF via down-regulating the expression of miR-382/miR-182, thus exhibiting a positive effect in the management of PSD. +circRNA target 36030248 hsa-mir-335 Glioma The glycolysis regulating enzyme ALDOA was regulated by circKIF4A through the mechanism of interactivity with miR +exosome 36030223 hsa-mir-6825 Colorectal Neoplasms CONCLUSION: lnc-HOXB8-1:2 in exosomes derived from neuroendocrine differentiated CRC cells acted as a ceRNA competitively binding hsa-miR5p to upregulate CXCR3 expression and leading to TAM infiltration and M2 polarization, which promotes neuroendocrine differentiated CRC progression. +transcription factor target 36029808 hsa-mir-702 Diabetic Neuropathies 5p has a neuroprotective effect on DE, and this effect was achieved by inhibiting 12/15-LOX. +other 36029681 hsa-mir-21 Breast Neoplasms Because miRNA-21 is over-expressed in cancer cells, it has been tested in total RNA samples isolated from cancer cell line (breast cancer cell line, MCF-7). +circulation_biomarker_diagnosis_ns 36029501 hsa-mir-21 Carcinoma, Renal Cell Correlation of miRNA-21 and blood Cr levels with tumor infiltration and distant The object of this study was to explore the correlation analysis between miRNA-21 and blood Cr levels with tumor invasion and distant metastasis in renal cancer patients. It is concluded when renal cancer patients were tested, we found that miRNA-21 and blood Cr levels were abnormally increased, and the two had a certain correlation with renal cancer tumor invasion and distant metastasis, which showed a positive correlation. +transcription factor target 36029500 hsa-mir-497 Hypoxia The experimental results of this study prove that miR-497 can alleviate the damage caused by hypoxia-reoxygenation of cardiomyocytes by regulating target genes BCL-2 and LC3B. +exosome 36029497 hsa-mir-103 Carcinoma, Hepatocellular The purpose of this article is to investigate the role and mechanism of exosome microRNA-103 in hepatocellular carcinoma cell proliferation and invasion. +lncRNA target 36029493 hsa-mir-218 Glioma This study aimed to discover the molecular mechanism of mir-218 targeting the regulation of robol expression on proliferation, invasion and migration of glioma cells and to provide a theoretical and experimental basis for finding therapeutic targets of glioma. +other 36029367 hsa-mir-200 Neurodegenerative Diseases Synergistic Effect of miR-200 and Young Extracellular Matrix-based Bio-scaffolds Aging is defined as a complex, multifaceted degenerative process that causes a gradual decline of physiological functions and a rising mortality risk with time. +genetics_overexpression_promote 36029292 hsa-mir-143 Inflammatory Bowel Diseases In UC rats, cycloastragenol significantly reduced expression levels of SphK, MIP-1alpha, BAX, NF-kappaB, TNF-alpha and active caspase-3, associated with BCL2 and miR-143 overexpression. +lncRNA target 36029209 hsa-mir-637 Carcinoma, Hepatocellular CONCLUSION: Circ_SNX27 contributed to HCC development via miR-637/FGFR1 axis, offering a new idea for the treatment of HCC. +other 36029069 hsa-mir-16 Adenocarcinoma of Lung The present findings support further investigation of the anti-cancer effect of miR-16 in animal models of lung cancer to validate the therapeutic potential. +other 36028828 hsa-mir-146a Diffuse Alveolar Hemorrhage, Autoimmune-Mediated CONCLUSIONS: Our results demonstrate firstly down-regulated pulmonary miR-146a levels with increased TRAF6 and IL-8 expression and NETs and apoptosis formation in autoimmune-mediated DAH, and implicate a therapeutic potential of intra-pulmonary miR-146a delivery. +transcription factor target 36028821 hsa-mir-1248 Colorectal Neoplasms CONCLUSION: Hsa-miR-1248 may act as a tumor suppressor gene in CRC by targeting and inhibiting PSMD10, which provides a clue for CRC treatment. +other 36028080 hsa-mir-490 Cardiotoxicity In summary, miR5p and its downstream genes, SNAP91 and LYPD6 are associated with PFOA-induced developmental cardiotoxicity in chicken embryo, which might help to further elucidate the mechanism of PFOA-induced developmental cardiotoxicity. +other 36028011 hsa-mir-134 Bipolar Disorder 3p levels were calculated to have 83.3 % sensitivity and 78.8 % specificity in determining the risk of BD. +other 36028011 hsa-mir-652 Bipolar Disorder 3p levels were calculated to have 83.3 % sensitivity and 78.8 % specificity in determining the risk of BD. +other 36028011 hsa-mir-15b Bipolar Disorder 3p levels were calculated to have 83.3 % sensitivity and 78.8 % specificity in determining the risk of BD. +other 36028011 hsa-mir-155 Bipolar Disorder 3p levels were calculated to have 83.3 % sensitivity and 78.8 % specificity in determining the risk of BD. +circulation_biomarker_diagnosis_up 36027941 hsa-mir-210 Ischemic Stroke The results showed 1) H/R induced apoptosis and ROS overproduction in neurons; 2) miR-210 mimic increased the level of miR-210 in both EPCs and EPC-EXs; 3) EPCs cultured in serum-free medium released more exosomes in comparison with cells grown in complete growth media, suggesting serum starving induce the release of EXs; 4) After transfection, EPCs grown in complete media had almost 50 times higher miR-210 level than EPCs had in serum-free media, while the EPCs-EXs isolated from the complete media has lower miR-210 expression than from the serum-free media in a time-dependent manner, suggesting the transfer of miR-210 through EXs; 5) After co-incubation, EPC-EXs and miR210-EPC-EXs were uptaken by neurons, and the miR-210 level in neurons was elevated by miR210-EPC-EXs; 6) miR210-EPC-EXs were more effective in promoting cell viability and decreasing apoptosis and ROS production than EPC-EXs. +genetics_knock down_promote 36027936 hsa-mir-577 Breast Neoplasms Finally, the rescuing experiments evidenced that both POSTN knockdown and ILK/Akt/mTOR pathway inhibitor OSU-T315 abrogated the promoting effects of miR-577 ablation on the malignant phenotypes in BC. +exosome 36027869 hsa-mir-181c Carcinoma, Ovarian Epithelial Extracellular vesicle-packaged miR-181c-5p from epithelial ovarian cancer cells OBJECTIVES: The molecular mechanistic actions of tumor-derived extracellular vesicles (EVs) in modulating macrophage polarization in the tumor microenvironment of epithelial ovarian cancer (EOC) is largely unknown. +lncRNA target 36027040 hsa-mir-124 Ischemic Stroke, Diabetic In this study we assessed the association of the lncRNA Nuclear enriched abundant transcript 1 (NEAT1)'s expression and its target miRNA-124 with acute ischemic stroke (AIS) in type II diabetic patients (T2DM). In comparison to the AIS-only patients, DM patients and controls, miR-124 expression was considerably lower in the DM+AIS group. +genetics_overexpression_promote 36027039 hsa-mir-504 Carcinoma, Non-Small-Cell Lung Overexpression of miR +other 36018564 hsa-mir-597 Myelodysplastic Syndromes CONCLUSION: These findings suggest that upregulation of miR-597 induces apoptosis and that miR-597 has a possible role in the pathophysiology of MDS. +target gene 36018563 hsa-mir-378a Graves Disease hsa_circ_0090364 may regulate the JAK-STAT pathway via the hsa-miR-378a-3p/IL-6ST/IL21R axis to promote cell growth. +genetics_knock down_suppress 36018460 hsa-mir-582 Uterine Cervical Neoplasms In summary, circ_0042986 overexpression decoyed miR +exosome 36018423 hsa-mir-29b Aortic Diseases By exosomal microRNA microarray analysis, we found that microRNA-29b was significantly reduced in aortic endothelial cells (AECs) receiving TAC. By contrast, antagonizing miR-29b in vivo further enhanced TAC-induced expressions of MMP12 and osteopontin, aggravated aortic fibrosis, calcification, and stiffness. +exosome 36018423 hsa-mir-29b Diarrhea 5, With Tufting Enteropathy, Congenital By exosomal microRNA microarray analysis, we found that microRNA-29b was significantly reduced in aortic endothelial cells (AECs) receiving TAC. By contrast, antagonizing miR-29b in vivo further enhanced TAC-induced expressions of MMP12 and osteopontin, aggravated aortic fibrosis, calcification, and stiffness. +exosome 36018178 hsa-mir-23b Cerebral Hemorrhage These findings suggest that BMSC-derived exosomal miR-23b exhibits antioxidant effects through inhibiting PTEN and alleviating NLRP3 inflammasome-mediated pyroptosis, thereby promoting neurologic function recovery in rats with ICH. +exosome 36018178 hsa-mir-23b Syphilis These findings suggest that BMSC-derived exosomal miR-23b exhibits antioxidant effects through inhibiting PTEN and alleviating NLRP3 inflammasome-mediated pyroptosis, thereby promoting neurologic function recovery in rats with ICH. +exosome 36018063 hsa-mir-130b Acute Lung Injury The present study was performed to elucidate the miR-130b-3p-involved mechanism in acute lung injury (ALI) through delivery by mesenchymal stem cells-derived exosomes (MSCs-Exo). +lncRNA target 36017918 hsa-mir-335 Urinary Bladder Neoplasms 5p to regulate the expression of downstream target gene IER2, forming a complete PCAT19/miR +genetics_overexpression_suppress 36017917 hsa-mir-1252 Stomach Neoplasms Overexpression of THUMPD3-AS1 inhibits proliferation, migration, invasion and ROS accumulation of gastric cancer cells by regulation of miR3p and CXCL17. +genetics_overexpression_promote 36017916 hsa-mir-29c lung squamous cell carcinoma LSCC cells H1581 and H1993 were transfected with PLAC2 and cyclin-dependent kinase 6 (CDK6) expression vectors and small interfering RNAs (siRNAs), as well as microRNA-29C (miR-29C) mimic and inhibitor to perform overexpression and knock-down experiment, respectively. +circRNA target 36017914 hsa-mir-485 Colorectal Neoplasms 5p, as the target of circHIPK2 in CRC model, played a role in promoting CRC progression and expediting HSP90 ubiquitination. +genetics_overexpression_promote 36017912 hsa-mir-587 Urinary Bladder Neoplasms miR-587 has been shown to be a target of PGM5-AS1, and miR-587 overexpression can reverse the inhibitory effect of PGM5-AS1 upregulation on BC cell growth. +genetics_overexpression_promote 36017911 hsa-mir-21 Neuroblastoma PCAT29 overexpression promoted NB cell apoptosis, while miR-21 overexpression inhibited NB cell apoptosis and attenuated PCAT29 overexpression-mediated NB cell apoptosis. +other 36017856 hsa-mir-1324 Carcinoma, Hepatocellular CONCLUSION: Circ_0006789 modulates the growth, migration and invasion of HCC cells by regulating miR-1324/SOX12 axis. +other 36017689 hsa-mir-742 Renal Insufficiency, Chronic 5p were significantly reduced at both 4 and 16 weeks. +other 36017689 hsa-mir-742 Vascular Calcification 5p were significantly reduced at both 4 and 16 weeks. +other 36017689 hsa-mir-22 Vascular Calcification 5p were significantly reduced at both 4 and 16 weeks. +other 36017689 hsa-mir-298 Renal Insufficiency, Chronic 5p were significantly reduced at both 4 and 16 weeks. +other 36017689 hsa-mir-568 Vascular Calcification 5p were significantly reduced at both 4 and 16 weeks. +other 36017689 hsa-mir-542 Renal Insufficiency, Chronic 5p were significantly reduced at both 4 and 16 weeks. +other 36017689 hsa-mir-542 Vascular Calcification 5p were significantly reduced at both 4 and 16 weeks. +other 36017689 hsa-mir-568 Renal Insufficiency, Chronic 5p were significantly reduced at both 4 and 16 weeks. +other 36017689 hsa-mir-298 Vascular Calcification 5p were significantly reduced at both 4 and 16 weeks. +other 36017689 hsa-mir-376b Vascular Calcification 5p were significantly reduced at both 4 and 16 weeks. +other 36017689 hsa-mir-22 Renal Insufficiency, Chronic 5p were significantly reduced at both 4 and 16 weeks. +other 36017689 hsa-mir-376b Renal Insufficiency, Chronic 5p were significantly reduced at both 4 and 16 weeks. +other 36017315 hsa-mir-652 Diabetes Mellitus, Type 2 3p. +other 36017315 hsa-mir-1303 Diabetes Mellitus, Type 2 3p. +other 36017315 hsa-mir-571 Diabetes Mellitus, Type 2 3p. +other 36017315 hsa-mir-661 Diabetes Mellitus, Type 2 3p. +other 36017315 hsa-mir-892b Diabetes Mellitus, Type 2 3p. +other 36017315 hsa-mir-770 Diabetes Mellitus, Type 2 3p. +other 36017315 hsa-let-7e Diabetes Mellitus, Type 2 3p. +genetics_overexpression_promote 36017148 hsa-mir-96 Adenocarcinoma of Lung Overexpression of miR5p suppressed FHL1 expression in LUAD cells and promoted proliferation, invasion, and migration of LUAD cells, while overexpression of FHL1 could simultaneously restore the above-mentioned promoting effect. +other 36016920 hsa-mir-34a Chronic Periodontitis CONCLUSION: There is an abnormally high expression of miR-34a in GCF of chronic periodontitis. +other 36016885 hsa-mir-181 Mucocutaneous Lymph Node Syndrome The miR-181 family contributes to the pathogenesis of cardiovascular and inflammatory disorders, while Nanos3 is involved in DNA transcription regulation and cell proliferation. +genetics_GWAS 36016885 hsa-mir-181c Mucocutaneous Lymph Node Syndrome CONCLUSION: SNP rs8108402 C/T located in the miR-181c/d promoter and Nanos3 intronic region is associated with susceptibility to Kawasaki disease but not with the development of coronary artery lesions or IVIG unresponsiveness in Chinese children. +genetics_GWAS 36016885 hsa-mir-181d Mucocutaneous Lymph Node Syndrome CONCLUSION: SNP rs8108402 C/T located in the miR-181c/d promoter and Nanos3 intronic region is associated with susceptibility to Kawasaki disease but not with the development of coronary artery lesions or IVIG unresponsiveness in Chinese children. +lncRNA target 36016863 hsa-mir-24 Digestive System Neoplasms 3p seems to target CDK4 (cyclin-dependent kinase 4); then potentially inhibiting their expression, both miRNAs can induce a negative regulation of cell cycle progression. +lncRNA target 36016863 hsa-mir-15 Endocrine Gland Neoplasms 3p seems to target CDK4 (cyclin-dependent kinase 4); then potentially inhibiting their expression, both miRNAs can induce a negative regulation of cell cycle progression. +lncRNA target 36016863 hsa-mir-24 Endocrine Gland Neoplasms 3p seems to target CDK4 (cyclin-dependent kinase 4); then potentially inhibiting their expression, both miRNAs can induce a negative regulation of cell cycle progression. +lncRNA target 36016863 hsa-mir-15 Digestive System Neoplasms 3p seems to target CDK4 (cyclin-dependent kinase 4); then potentially inhibiting their expression, both miRNAs can induce a negative regulation of cell cycle progression. +lncRNA target 36016851 hsa-mir-184 Carcinoma, Non-Small-Cell Lung In a word, this study indicated that circCNN2 activated MAPK signaling pathway through the miR-184/E2F1 axis to promote proliferation and invasion of LUSC cells. +genetics_GWAS 36016604 hsa-mir-671 Sarcoma The results showed that miR-671 rs1870238 GC CC (OR = 1.963, 95% CI = 1.258-3.064, P = 0.003) and miR-671 rs2446065 CG GG (OR =1.838, 95% CI = 1.178-2.868, P = 0.007) may be genetic risk factors for STSs after adjustment for age and smoking. Therefore, this study suggests that individuals carrying the GC CC genotype for miR-671 rs1870238 or the CG GG genotype for miR-671 rs2446065 are susceptible to STSs. +lncRNA target 36016581 hsa-mir-942 Squamous Cell Carcinoma of Head and Neck 5p/HSPD1 axis is a potential target for OSCC. +lncRNA target 36016468 hsa-mir-148b Ovarian Neoplasms Most importantly, the si-LINC00665 could reverse the promotion effect of the miR-148b-3p inhibitor on the malignant biological behavior of OC cells. +transcription factor target 36014967 hsa-mir-155 Stomach Neoplasms 5p could be a therapeutic target for GC related to CagA. +circulation_biomarker_diagnosis_up 36014577 hsa-mir-21 Lung Neoplasms Exosomal MicroRNA-21 (miRNA-21, miR-21) is significantly up-regulated in blood samples of patients with lung cancer. +other 36013894 hsa-mir-132 Pancreatic Carcinoma In this work, the presence of a specific pancreatic cancer-derived miRNA (pre-miR-132) is detected using the fluorescence properties of biocompatible nitrogen-doped graphene quantum dots (NGQDs) synthesized using a bottom-up approach from a single glucosamine precursor. +other 36012644 hsa-mir-223 Pulmonary Fibrosis We showed that ectopic expression of miR-223 in HSCs attenuated fibrogenesis in the two human organoid models of liver injury, suggesting its potential application in antifibrotic therapy. +other 36012644 hsa-mir-233 Pulmonary Fibrosis Finally, to explore the therapeutic potential of miR-233 in liver fibrosis, we generated co-cultured organoids of HSCs with Huh7 hepatoma cells and challenged them with acetaminophen (APAP) or palmitic acid (PA) to induce hepatotoxicity. +other 36012644 hsa-mir-233 Liver Injury Finally, to explore the therapeutic potential of miR-233 in liver fibrosis, we generated co-cultured organoids of HSCs with Huh7 hepatoma cells and challenged them with acetaminophen (APAP) or palmitic acid (PA) to induce hepatotoxicity. +other 36012644 hsa-mir-223 Liver Injury We showed that ectopic expression of miR-223 in HSCs attenuated fibrogenesis in the two human organoid models of liver injury, suggesting its potential application in antifibrotic therapy. +lncRNA target 36012615 hsa-mir-145 Cystic Fibrosis Targeting of miR +lncRNA target 36012615 hsa-mir-101 Cystic Fibrosis Targeting of miR +lncRNA target 36012615 hsa-mir-335 Cystic Fibrosis Targeting of miR +lncRNA target 36012303 hsa-let-7d Pulmonary Fibrosis In silico analysis revealed COL3A1 and SMAD2, proteins involved in the development of IPF, as Let-7d targets. +transcription factor target 36011411 hsa-mir-18a Glaucoma Together, these findings identify miR-18a-5p as a mediator of the TGFbeta2 response and a candidate therapeutic agent for glaucoma via its ability to inhibit CTGF-associated increased TM contractility. +transcription factor target 36011378 hsa-mir-107 Lipid Metabolism Disorders Moreover, for the highly conserved among different species, miR-107 may be a potential molecular target to be used for the treatment of lipid-related diseases in the future. +epigenetics 36011313 hsa-mir-203 Lymphoma, Large B-Cell, Diffuse The methylation frequencies of the MIR +epigenetics 36011313 hsa-mir-129-2 Lymphoma, Large B-Cell, Diffuse The methylation frequencies of the MIR +epigenetics 36011313 hsa-mir-34b Lymphoma, Large B-Cell, Diffuse The methylation frequencies of the MIR +epigenetics 36011313 hsa-mir-34a Lymphoma, Large B-Cell, Diffuse The methylation frequencies of the MIR +lncRNA target 36011286 hsa-mir-23b Carcinoma, Hepatocellular CONCLUSION: Our study highlights the cytoprotective role of autophagy and glutamine addiction modulated by miR-23b-3p (tumor suppressor), suggesting new approaches to curb sorafenib resistance in HCC. +other 36010613 hsa-mir-7 Alzheimer Disease We recently described that miR-7, a novel candidate for linking AD and T2DM at the molecular level, regulates IDE and other key genes in both pathologies, including some key genes involved in the insulin signaling pathway. +other 36010613 hsa-mir-7 Diabetes Mellitus, Type 2 We recently described that miR-7, a novel candidate for linking AD and T2DM at the molecular level, regulates IDE and other key genes in both pathologies, including some key genes involved in the insulin signaling pathway. +other 36010581 hsa-mir-29c Atrophy Additionally, myogenic microRNAs (e.g., miR-1 and miR-206), and hypertrophy-associated microRNAs (e.g., miR-27a-3p, miR-29c, and miR-29c) were reciprocally expressed to favor hypertrophy during muscle recovery. +other 36010581 hsa-mir-137 Atrophy Autophagy-related 2A, F-box and WD repeat domain containing 7, F-box only protein 32, miR-137, and miR-153 showed exceptional high expression suggesting them as master regulators of muscle atrophy. +other 36010581 hsa-mir-1 Atrophy Additionally, myogenic microRNAs (e.g., miR-1 and miR-206), and hypertrophy-associated microRNAs (e.g., miR-27a-3p, miR-29c, and miR-29c) were reciprocally expressed to favor hypertrophy during muscle recovery. +other 36010581 hsa-mir-206 Atrophy Additionally, myogenic microRNAs (e.g., miR-1 and miR-206), and hypertrophy-associated microRNAs (e.g., miR-27a-3p, miR-29c, and miR-29c) were reciprocally expressed to favor hypertrophy during muscle recovery. +other 36010581 hsa-mir-27a Atrophy Additionally, myogenic microRNAs (e.g., miR-1 and miR-206), and hypertrophy-associated microRNAs (e.g., miR-27a-3p, miR-29c, and miR-29c) were reciprocally expressed to favor hypertrophy during muscle recovery. +other 36010581 hsa-mir-153 Atrophy Autophagy-related 2A, F-box and WD repeat domain containing 7, F-box only protein 32, miR-137, and miR-153 showed exceptional high expression suggesting them as master regulators of muscle atrophy. +other 36010296 hsa-mir-146a ST Elevation Myocardial Infarction 3p and miR-146a-5p) have the potential to be used as prognostic markers for adverse events after acute myocardial infarction. +other 36010296 hsa-mir-223 ST Elevation Myocardial Infarction 3p and miR-146a-5p) have the potential to be used as prognostic markers for adverse events after acute myocardial infarction. +other 36010296 hsa-mir-142 ST Elevation Myocardial Infarction 3p and miR-146a-5p) have the potential to be used as prognostic markers for adverse events after acute myocardial infarction. +other 36010264 hsa-mir-148b Cognition Disorders Our results suggest that miRNAs such as hsa-mir-148b-3p, hsa-mir-7b-5p, and hsa-mir-7a-5p are commonly associated with MS and cognitive dysfunction. +other 36010264 hsa-mir-7a Multiple Sclerosis Our results suggest that miRNAs such as hsa-mir-148b-3p, hsa-mir-7b-5p, and hsa-mir-7a-5p are commonly associated with MS and cognitive dysfunction. +other 36010264 hsa-mir-7a Cognition Disorders Our results suggest that miRNAs such as hsa-mir-148b-3p, hsa-mir-7b-5p, and hsa-mir-7a-5p are commonly associated with MS and cognitive dysfunction. +other 36010264 hsa-mir-7b Multiple Sclerosis Our results suggest that miRNAs such as hsa-mir-148b-3p, hsa-mir-7b-5p, and hsa-mir-7a-5p are commonly associated with MS and cognitive dysfunction. +other 36010264 hsa-mir-7b Cognition Disorders Our results suggest that miRNAs such as hsa-mir-148b-3p, hsa-mir-7b-5p, and hsa-mir-7a-5p are commonly associated with MS and cognitive dysfunction. +other 36010264 hsa-mir-148b Multiple Sclerosis Our results suggest that miRNAs such as hsa-mir-148b-3p, hsa-mir-7b-5p, and hsa-mir-7a-5p are commonly associated with MS and cognitive dysfunction. +circulation_biomarker_diagnosis_up 36010252 hsa-mir-146a Liver Cirrhosis These findings demonstrate the potential utility of serum miRNAs, particularly of miR-146a, as a supplementary tool for assessing hepatic fibrosis in chronic schistosomiasis japonica patients. +circulation_biomarker_diagnosis_up 36010252 hsa-mir-146a Schistosomiasis These findings demonstrate the potential utility of serum miRNAs, particularly of miR-146a, as a supplementary tool for assessing hepatic fibrosis in chronic schistosomiasis japonica patients. +other 36009855 hsa-mir-21 Jaundice, Acute MicroRNA-122 expression was elevated in cases of AR and RH (p < 0.05); miRNA-301 and miRNA-21 expression was higher in RH than in AC (p < 0.05); and miRNA-133a expression was higher in FC than in AR (p < 0.05). +other 36009855 hsa-mir-133a Jaundice, Acute MicroRNA-122 expression was elevated in cases of AR and RH (p < 0.05); miRNA-301 and miRNA-21 expression was higher in RH than in AC (p < 0.05); and miRNA-133a expression was higher in FC than in AR (p < 0.05). +other 36009855 hsa-mir-122 Jaundice, Acute MicroRNA-122 expression was elevated in cases of AR and RH (p < 0.05); miRNA-301 and miRNA-21 expression was higher in RH than in AC (p < 0.05); and miRNA-133a expression was higher in FC than in AR (p < 0.05). +other 36009075 hsa-mir-516b Glioblastoma Conclusions The OSMR-AS1/ miR-516b-5p axis was identified as the highest-potential upstream ncRNA-related pathway of H6PD in GBM. +circulation_biomarker_diagnosis_ns 36009063 hsa-mir-3123 Ischemic Stroke Serum microRNA miR +circulation_biomarker_diagnosis_ns 36009063 hsa-mir-206 Ischemic Stroke Higher serum miR-206 level independently increased the risk of spontaneous HT in AIS patients. +circulation_biomarker_diagnosis_ns 36009063 hsa-mir-21 Ischemic Stroke Serum microRNA miR +circulation_biomarker_diagnosis_ns 36009063 hsa-mir-491 Ischemic Stroke Serum microRNA miR +circulation_biomarker_diagnosis_ns 36009038 hsa-mir-135a Endometriosis This indicates that hsa-mir-135a is a putative noninvasive biomarker of endometriosis in both saliva and plasma, but further validation studies are required to assess its clinical value as a biomarker. +other 36009031 hsa-mir-449b Brain Ischemia Our study showed that LRIC promoted the proliferation and migration of neural stem cells after MCAO, and these effects were modulated by the miR-449b/Notch1 pathway. +genetics_overexpression_promote 36008842 hsa-mir-1254 Uterine Cervical Neoplasms CD36 overexpression reversed the inhibitory effects of upregulated miR-1254 in the cervical cancer cells, suggesting that miR-1254 regulates cervical cancer progression by modulating CD36. +lncRNA target 36008700 hsa-mir-497 Carcinoma, Hepatocellular 5p played a tumor-inhibitory role in HCC cells by targeting ANXA11. +circRNA target 36008392 hsa-mir-6820 Carcinoma, Pancreatic Ductal In conclusion, our findings reveal that hsa_circ_0007367 acts as an oncogene via modulating miR +genetics_overexpression_promote 36008375 hsa-mir-10b Squamous Cell Carcinoma of Head and Neck Overexpression of miR-10b was followed by enhanced OSCC invasion and migration and activated autophagic protein, such as LC3II/ATG5. +exosome 36007833 hsa-mir-122 Osteoarthritis We concluded that OA-Exos may, through the miR-122/HO-1 pathway, reduce immune function and antioxidant defence in CIK cells. +other 36007832 hsa-mir-750 Lichen Sclerosus et Atrophicus Penaeus monodon miR-750 (pmo-miR-750) was found to be strongly up-regulated in the late phase of white spot syndrome virus (WSSV) infection, but its function remains uncharacterized. +lncRNA target 36007832 hsa-mir-750 Werner Syndrome Collectively, our findings reveal that up-regulated pmo-miR-750 suppresses Scp expression at both the transcript and protein levels in the late stage of WSSV infection, which contributes to modulating apoptosis and eventually enabling viral propagation. +transcription factor target 36007337 hsa-mir-767 Melanoma 3p was shown to inhibit ASF1B which will attenuate melanoma tumorigenesis, and by this it can be a potential new effective biomarker for the treatment of melanoma. +transcription factor target 36006565 hsa-mir-223 Brain Ischemia Further, miR3p resulted in the decreased cell viability and glucose uptake and the increased cell apoptosis to cause ischemic brain damage. +exosome 36006542 hsa-mir-342 Venous Thrombosis 3p loaded by hucMSCs-exos attenuates DVT by downregulating EDNRA, offering a novel direction to treat DVT. +circulation_biomarker_diagnosis_ns 36006370 hsa-mir-155 Atherosclerosis Moreover, detection of circulating EVs-carried miR-155 expression may reveal the progression of atherosclerosis. On the molecular level, blocking miR-155 biogenesis, which constituted a novel therapeutic approach, may protect against nicotine aggravating atherosclerosis. +circulation_biomarker_diagnosis_ns 36006370 hsa-mir-155 limb ischemia Moreover, detection of circulating EVs-carried miR-155 expression may reveal the progression of atherosclerosis. On the molecular level, blocking miR-155 biogenesis, which constituted a novel therapeutic approach, may protect against nicotine aggravating atherosclerosis. +transcription factor target 36005571 hsa-mir-1 Hypothermia Furthermore, transcriptional expression of key genes demonstrates hypothermia-activated AMPK signaling by miR-1 and subsequently inhibited the downstream glucogenic and glycogenic gene expression and gene expression of fatty acid synthesis. In conclusion, these results suggest that miR-1/AMPK is an important target for chronic hypothermia control. +other 36005478 hsa-mir-199a Stomach Neoplasms Our findings point toward the critical role of CAFs-derived EVs carrying miR-199a-5p in gastric cancer progression. +genetics_overexpression_promote 36004693 hsa-mir-576 Colonic Neoplasms 5p overexpression notably facilitated the proliferative, migratory, invasive abilities of colon adenocarcinoma cells. +transcription factor target 36004692 hsa-mir-944 Carcinoma, Hepatocellular Our study demonstrated that ciRS-7 enhanced the proliferation, migration, and invasion of HCC through miR-944/NOX4 pathway. +genetics_overexpression_promote 36004691 hsa-mir-25 Thyroid Cancer, Papillary miR-25 overexpression increased PTC cell proliferation. +lncRNA target 36004648 hsa-mir-214 Osteosarcoma 5p/SOX4 feedback loop performs an important role in OS progression and might be used as a new potential therapeutic target for the treatment of OS. +other 36004563 hsa-mir-449c Carcinoma, Hepatocellular Here, we found that ACOT9 expression is significantly elevated in HCC at least partially due to the down-regulation of miR-449c-3p. +genetics_knock down_promote 36004524 hsa-mir-433 Multiple Myeloma 3p downregulation or PBX3 overexpression reversed the inhibition effect of circ_0003489 knockdown on MM progression. +genetics_knock down_promote 36004511 hsa-mir-186 Leukemia, Myeloid, Acute 5p expression weakened circ_0044907 knockdown mediated suppression on AML cell viability, proliferation, and cycle progression. +other 36004323 hsa-mir-223 Chagas Cardiomyopathy 5p with CCM worsening. +lncRNA target 36003920 hsa-mir-29b Lung Neoplasms CONCLUSION: The results of this study indicate that miR-29b inhibits the proliferation and deterioration of NSCLC cells by targeting FEM1B and inhibiting the activation of the FOXO1/AKT pathway. +circulation_biomarker_diagnosis_ns 36003409 hsa-mir-23a Osteoarthritis The different temporal expressions of seven microRNAs in plasma and synovial fluid-derived extracellular vesicles, eca-miR-451, eca-miR-25, eca-miR-215, eca-miR-92a, eca-miR-let-7c, eca-miR5p, and eca-miR-23a, and four snoRNAs, U3, snord15, snord46, and snord58, represent potential biomarkers for early osteoarthritis. +other 36003405 hsa-let-7b Uveal melanoma Furthermore, LINC00665/hsa-let-7b-5p/RBM15B axis and LINC00638/hsa-miR-103a-3p/RBM15B axis were found to be potential prognostic biomarkers in UM. +other 36003405 hsa-mir-103a Uveal melanoma Furthermore, LINC00665/hsa-let-7b-5p/RBM15B axis and LINC00638/hsa-miR-103a-3p/RBM15B axis were found to be potential prognostic biomarkers in UM. +other 36003338 hsa-mir-200a Urinary Bladder Neoplasms Meanwhile, we identified lncRNA OCIAD1-AS1/miR3p/GPM6B and lncRNA OCIAD1-AS1/miR-200a-3p/AKAP11 regulatory axes, which may play a potential role in the progression of BC. +other 36003338 hsa-mir-141 Urinary Bladder Neoplasms Meanwhile, we identified lncRNA OCIAD1-AS1/miR3p/GPM6B and lncRNA OCIAD1-AS1/miR-200a-3p/AKAP11 regulatory axes, which may play a potential role in the progression of BC. +transcription factor target 36003288 hsa-mir-204 Neuralgia CONCLUSION: These results suggested that miR5p may alleviate neuropathic pain and inflammation through targeted regulation of BRD4 expression. +transcription factor target 36003151 hsa-mir-202 Pathologic Processes Transcriptome comparison revealed >250 RNAs including both maternal and zygotic origins were dysregulated at MBT in the miR-202(-/-) embryos, corresponding with arrays of homeostatic disorders leading to massive apoptosis. +other 36003065 hsa-mir-210 Epilepsy METHODS: In a pilocarpine-induced epileptic rat model, the expressions of microRNA-210 (miR-210), TLR4, NF-kappaB1 and caspase-3 were assessed by a quantitative polymerase chain reaction and Western blotting. +lncRNA target 36003065 hsa-mir-210 Seizures This study aimed to determine whether microRNA-210 regulates seizure and apoptosis by targeting the TLR4 /NF-kappaB1 associated signaling pathway. +lncRNA target 36003063 hsa-mir-206 Carcinoma, Hepatocellular In conclusion, our results revealed that miR-206 could down-regulate the expression of CREB5 and inhibit the activation of PI3K/AKT signaling pathway, thereby preventing HCC growth and metastasis.Abbreviations: HCC: hepatocellular carcinoma; HBV or HCV: hepatitis B or C virus; miRNAs: microRNAs; CREB: cAMP response element-binding protein; CRE: cAMP response elements. +genetics_knock down_promote 36002666 hsa-mir-495 Cataract, Age-Related 3p overexpression or HDAC4 knockdown reversed the inhibition effect of circ_HIPK3 on H(2)O(2)-induced lens epithelial cell injury. +genetics_overexpression_promote 36002606 hsa-mir-200 Carcinoma, Non-Small-Cell Lung In conclusion, PFD-induced miR-200 overexpression in CAFs inhibits ZEB1 expression in NSCLC cells, and thus decelerates the migration, invasion and EMT process. +genetics_GWAS 36002591 hsa-mir-128a Diabetic Neuropathies CONCLUSIONS: These results provide new insight into the genetic predisposition to DN showing that two polymorphisms in MIR146A and MIR128A genes could significantly contribute to the development of early ocular preclinical signs of DN. +genetics_GWAS 36002591 hsa-mir-146a Diabetes Mellitus, Type 1 CONCLUSIONS: These results provide new insight into the genetic predisposition to DN showing that two polymorphisms in MIR146A and MIR128A genes could significantly contribute to the development of early ocular preclinical signs of DN. +genetics_GWAS 36002591 hsa-mir-146a Diabetic Neuropathies CONCLUSIONS: These results provide new insight into the genetic predisposition to DN showing that two polymorphisms in MIR146A and MIR128A genes could significantly contribute to the development of early ocular preclinical signs of DN. +genetics_GWAS 36002591 hsa-mir-128a Diabetes Mellitus, Type 1 CONCLUSIONS: These results provide new insight into the genetic predisposition to DN showing that two polymorphisms in MIR146A and MIR128A genes could significantly contribute to the development of early ocular preclinical signs of DN. +other 36002186 hsa-mir-21 Lung Neoplasms Syngeneic murine models for head and neck cancer (C57BLJ/6J), breast cancer (BALB/C) and lung cancer (C57BL/6J) were applied for examining the impact of Snail-miR21 axis on inflammasome activation in vivo. +other 36002186 hsa-mir-21 Breast Neoplasms Syngeneic murine models for head and neck cancer (C57BLJ/6J), breast cancer (BALB/C) and lung cancer (C57BL/6J) were applied for examining the impact of Snail-miR21 axis on inflammasome activation in vivo. +other 36002186 hsa-mir-21 Head and Neck Neoplasms Syngeneic murine models for head and neck cancer (C57BLJ/6J), breast cancer (BALB/C) and lung cancer (C57BL/6J) were applied for examining the impact of Snail-miR21 axis on inflammasome activation in vivo. +lncRNA target 36002076 hsa-mir-620 Thyroid Neoplasms Furthermore, IRF2BP2 was discovered to be a target of miR-620, which displayed low expression in THCA cells and tissues. +lncRNA target 36001751 hsa-mir-130b Obesity Together, these data identify the miR-130b/301b cluster as a new regulator that suppresses beige adipogenesis involving PGC-1alpha and AMPK signaling in iWAT and is therefore a potential therapeutic target against obesity and related metabolic disorders. +lncRNA target 36001751 hsa-mir-130b Metabolic Diseases The miRNA cluster miR-130b/301b is highly expressed in adipose tissues and has been implicated in metabolic diseases as a posttranscriptional regulator of mitochondrial biogenesis and lipid metabolism. Together, these data identify the miR-130b/301b cluster as a new regulator that suppresses beige adipogenesis involving PGC-1alpha and AMPK signaling in iWAT and is therefore a potential therapeutic target against obesity and related metabolic disorders. +other 36001412 hsa-mir-192 Cell Transformation, Neoplastic Pearson's correlations revealed positive association between miR-192 expression and E-cadherin and Bax/Bcl2 as well, and it was negatively correlated to alpha-fetoprotein, NF-kappaB and TGF-beta and the cellular atypia score. +lncRNA target 36001412 hsa-mir-192 Carcinoma, Hepatocellular Suppressed hepatic miR-192 and E-cadherin expression were detected in the HCC (DENA-CCL4) group accompanied by elevated tumor necrosis factor (TNF-alpha), interleukin (IL6)/NF-kappaB & TGF-beta1. +genetics_overexpression_promote 36001230 hsa-mir-488 Liver Cirrhosis TET3 inhibition induced by the overexpression of miR +exosome 36001206 hsa-mir-214 Osteoarthritis 3p exosomes in treating OA. +exosome 36001206 hsa-mir-214 Inflammation 3p exosomes in treating OA. +other 36001185 hsa-mir-326 Breast Neoplasms Circ_0008717 Sponges miR-326 to Elevate GATA6 Expression to Promote Breast Cancer Tumorigenicity. +other 36001113 hsa-mir-18a Liver Cirrhosis Meanwhile, UCA1 could competitively bind with miR18a to stabilize Smad3 to constitute a positive feedback pathway, which played a significant role in the promotion of liver fibrosis. UCA1 can competitively bind with miR18a, promote liver fibrosis by stabilizing Smad3, and form a UCA1-miR18a/Smad3 positive feedback. +circulation_biomarker_diagnosis_ns 36000352 hsa-mir-144 Muscular Dystrophy, Duchenne Clinical scales to evaluate muscle injury (Vignos, GMFCS, Brooke, and Medical Research Council), enzymatic muscle injury parameters (CPK, ALT, and AST), anthropometry, metabolic indicators, physical activity, serum dystromiRs (miR +circulation_biomarker_diagnosis_ns 36000352 hsa-mir-133a Muscular Dystrophy, Duchenne Clinical scales to evaluate muscle injury (Vignos, GMFCS, Brooke, and Medical Research Council), enzymatic muscle injury parameters (CPK, ALT, and AST), anthropometry, metabolic indicators, physical activity, serum dystromiRs (miR +circulation_biomarker_diagnosis_ns 36000352 hsa-mir-21 Muscular Dystrophy, Duchenne Clinical scales to evaluate muscle injury (Vignos, GMFCS, Brooke, and Medical Research Council), enzymatic muscle injury parameters (CPK, ALT, and AST), anthropometry, metabolic indicators, physical activity, serum dystromiRs (miR +circulation_biomarker_diagnosis_ns 36000352 hsa-mir-1 Muscular Dystrophy, Duchenne Clinical scales to evaluate muscle injury (Vignos, GMFCS, Brooke, and Medical Research Council), enzymatic muscle injury parameters (CPK, ALT, and AST), anthropometry, metabolic indicators, physical activity, serum dystromiRs (miR +circulation_biomarker_diagnosis_ns 36000352 hsa-mir-128 Muscular Dystrophy, Duchenne Clinical scales to evaluate muscle injury (Vignos, GMFCS, Brooke, and Medical Research Council), enzymatic muscle injury parameters (CPK, ALT, and AST), anthropometry, metabolic indicators, physical activity, serum dystromiRs (miR +circulation_biomarker_diagnosis_ns 36000352 hsa-mir-206 Muscular Dystrophy, Duchenne Clinical scales to evaluate muscle injury (Vignos, GMFCS, Brooke, and Medical Research Council), enzymatic muscle injury parameters (CPK, ALT, and AST), anthropometry, metabolic indicators, physical activity, serum dystromiRs (miR +lncRNA target 36000339 hsa-mir-186 Postoperative Cognitive Complications CONCLUSION: OIP5-AS1 plays a neuroprotective role in elderly POCD rats through sponging miR +transcription factor target 36000159 hsa-mir-106a Asthma After confirmation of miRNAs expression through qRT-PCR, four of them (namely hsa-miR-106a-5p, hsa-miR-18a-5p, hsa-miR3p, and hsa-miR-375) manifested significant differential expression between asthmatic children and healthy controls. +transcription factor target 36000159 hsa-mir-375 Asthma After confirmation of miRNAs expression through qRT-PCR, four of them (namely hsa-miR-106a-5p, hsa-miR-18a-5p, hsa-miR3p, and hsa-miR-375) manifested significant differential expression between asthmatic children and healthy controls. +transcription factor target 36000159 hsa-mir-18a Asthma After confirmation of miRNAs expression through qRT-PCR, four of them (namely hsa-miR-106a-5p, hsa-miR-18a-5p, hsa-miR3p, and hsa-miR-375) manifested significant differential expression between asthmatic children and healthy controls. +transcription factor target 36000159 hsa-mir-144 Asthma After confirmation of miRNAs expression through qRT-PCR, four of them (namely hsa-miR-106a-5p, hsa-miR-18a-5p, hsa-miR3p, and hsa-miR-375) manifested significant differential expression between asthmatic children and healthy controls. +other 35999259 hsa-mir-145 Leukemia, Myelogenous, Chronic, BCR-ABL Positive We demonstrated that a combination of miR-145 and miR-708 are effective predictors of NL response in treatment-naive patients whereas miR-150 and miR-185 were significant classifiers at 1-month and 3-month post-NL therapy. +other 35999259 hsa-mir-708 Leukemia, Myelogenous, Chronic, BCR-ABL Positive We demonstrated that a combination of miR-145 and miR-708 are effective predictors of NL response in treatment-naive patients whereas miR-150 and miR-185 were significant classifiers at 1-month and 3-month post-NL therapy. +other 35999259 hsa-mir-150 Leukemia, Myelogenous, Chronic, BCR-ABL Positive We demonstrated that a combination of miR-145 and miR-708 are effective predictors of NL response in treatment-naive patients whereas miR-150 and miR-185 were significant classifiers at 1-month and 3-month post-NL therapy. +exosome 35999213 hsa-mir-1290 Prostatic Neoplasms Cancer associated fibroblasts secreted exosomal miR-1290 contributes to prostate cancer cell growth and metastasis via targeting GSK3beta. +genetics_GWAS 35999071 hsa-mir-335 Hemorrhage 5p both could down-regulate dentin sialophosphoprotein expression, and both miRNAs could inhibit IGFBP7-AS1-mediated SHED odontogenetic differentiation via suppression of the extracellular signal-regulated kinase (ERK) pathway. +genetics_GWAS 35999071 hsa-mir-155 Hemorrhage 5p both could down-regulate dentin sialophosphoprotein expression, and both miRNAs could inhibit IGFBP7-AS1-mediated SHED odontogenetic differentiation via suppression of the extracellular signal-regulated kinase (ERK) pathway. +transcription factor target 35998789 hsa-mir-4813 Parkinson Disease miR3p modulates ER(UPR), MT(UPR), autophagosome-lysosomal-pathway and the ubiquitin-proteasomal-system, making this molecule an interesting target for further studies towards therapeutically addressing multifactorial aspect of Parkinson's disease. +lncRNA target 35998761 hsa-mir-224 Esophageal Squamous Cell Carcinoma 5p/CPEB3 suppresses ESCC progression by inactivating EGFR/PI3K/AKT signaling, providing a basis for developing circ_0007624-targeted therapies for ESCC patients. +other 35998511 hsa-mir-19a Diabetes Mellitus, Type 2 To assess the sensitivity and specificity of miR-19a and miR-221 expression as potential biomarkers for MI, the receiver operating characteristic curve (ROC) analysis was conducted for both diabetic groups. RESULTS: The diabetic MIDMet group exhibited a significant decrease in the expression levels of miR-221 (7.2 folds) and miR-19a (5.3 folds) as compared to the MIDMet- and MIND groups (p < 0.05). +other 35998511 hsa-mir-221 Diabetes Mellitus, Type 2 To assess the sensitivity and specificity of miR-19a and miR-221 expression as potential biomarkers for MI, the receiver operating characteristic curve (ROC) analysis was conducted for both diabetic groups. RESULTS: The diabetic MIDMet group exhibited a significant decrease in the expression levels of miR-221 (7.2 folds) and miR-19a (5.3 folds) as compared to the MIDMet- and MIND groups (p < 0.05). +other 35998503 hsa-mir-612 Thyroiditis, Autoimmune mediated BRD4 expression. +lncRNA target 35998476 hsa-mir-155 Liver Injury Here, we established a model of arsenic-induced chronic liver injury by providing rats with drinking water containing different concentrations of sodium arsenite (NaAsO(2)) and found that NaAsO(2) exposure decreased the mRNA and protein levels of AUF1 and the protein level of SOD1 and elevated the mRNA and protein levels of Dicer1 and miR-155 and the mRNA level of SOD1. A dual-luciferase reporter assay indicated that miR-155 decreased the mRNA and protein levels of SOD1 by targeting the SOD1 3'UTR, resulting in liver injury. +circulation_biomarker_diagnosis_ns 35998435 hsa-mir-34c Adenocarcinoma, Sinonasal Intestinal METHODS: MiR-34c-3p, lncRNA AF147447 and MUC2 were measured in tumors and normal mucosa, in nasal washings (NW) from the affected and non-affected nostril and in plasma from 17 ITAC patients. +genetics_knock down_promote 35998226 hsa-mir-17 Urinary Bladder Neoplasms The exosomes derived from PTENP1-overexpressing BMSC (BMSC(OE-PTENP1)-Exo) abolished the promotive effects of miR-17 overexpression or SCARA5 knockdown on the malignant phenotypes of BC cells. +transcription factor target 35998069 hsa-mir-574 Colitis CONCLUSIONS: Here, we describe a new mechanism by which Fn-EVs mediate experimental colitis severity through miR5p/CARD3-dependent autophagy activation, providing a novel target for UC monitoring and targeted therapy. +circulation_biomarker_diagnosis_ns 35997718 hsa-mir-144 Uremia 5p elevation reduced BUN, Scr, beta2-MG, P, and iPTH levels, and increased free Ca concentration in blood in uremic rats. +target gene 35997665 hsa-mir-148a Colonic Neoplasms MicroRNA-148a induces apoptosis and prevents angiogenesis with bevacizumab in colon cancer through direct inhibition of ROCK1/c-Met via HIF-1α under hypoxia. +exosome 35997581 hsa-mir-451 Acute Lung Injury In the previous study, we have proved that exosomal miR-451 from human umbilical cord mesenchymal stem cells (hUC-MSCs) attenuated burn-induced acute lung injury (ALI). In conclusion, we indicated that hUC-MSCs-derived exosomal miR-451 alleviated ALI by modulating macrophage M2 polarization via regulating MIF-PI3K-AKT signaling pathway, which provided great scientific significance and clinical application value for the treatment of burn-induced ALI. +lncRNA target 35997481 hsa-mir-223 Myocardial Infarction In addition, we conducted a series of rescue experiments to affirm that ZNF561-AS1 regulated cell proliferation and apoptosis in MI through miR3p/NLRP3 axis. +other 35997316 hsa-mir-496a Huntington Disease Downregulation of TRAX enhanced 83 miRNAs (including miR3p, miR-496a-3p) and subsequently changed the corresponding mRNA networks critical for HD pathogenesis (eg, DARPP-32 and brain-derived neurotrophic factor). +circulation_biomarker_diagnosis_down 35997271 hsa-mir-155 Pulmonary Fibrosis 5p antagomir and si-FOXO3a lentivirus plasmids. +genetics_overexpression_promote 35997119 hsa-mir-612 Retinoblastoma Results - Overexpression of ZFPM2-AS1 and NT5E and downregulation of miR-3612 expression levels were observed in RB cells and tissues. +genetics_overexpression_promote 35997118 hsa-mir-18b Esophageal Squamous Cell Carcinoma lncRNA ZNF667-AS1 overexpression accelerated RASA1 transcription by competitively binding to miR-18b-5p, thus suppressing ESCC cell proliferation and invasion. +genetics_knock down_suppress 35997116 hsa-mir-200b Incontinentia Pigmenti ZEB2 knockdown reversed the inhibitory effect of miR-200b-3p downregulation on IPC differentiation from UCMSCs in vitro. +lncRNA target 35997115 hsa-mir-335 Breast Neoplasms In breast cancer, SDC1 was a target gene of miR +genetics_overexpression_promote 35997114 hsa-mir-10a Carcinoma, Hepatocellular In HCC cells, overexpression of PCED1B-AS1 decreases miR-10a expression and increases BCL6 expression. +lncRNA target 35997113 hsa-mir-15a Liver Neoplasms In vivo assays were further performed and miR-15a-5p inhibited the growth of liver cancer. +circulation_biomarker_diagnosis_up 35997022 hsa-mir-29 Pulmonary Arterial Hypertension In the cytoplasm, circSMOC1 acted as a miR +lncRNA target 35996717 hsa-mir-21 Adenocarcinoma of Lung CONCLUSION: Calycosin can inhibit colony formation, invasion, migration, and EMT process of LUAD cells via regulating the circ_0001946/miR-21/GPD1L/HIF-1alpha signaling axis and could be a promising therapeutic drug for LUAD. +genetics_GWAS 35996522 hsa-mir-499 Polycystic Ovary Syndrome Conclusion: Single SNPs and haplotype combinations in certain SNPs in miR-126, miR-146a, miR-196a2 and miR-499 are strongly linked to PCOS, and so may be useful predictors of this condition. +genetics_GWAS 35996520 hsa-mir-137 Gastric And Colon Cancer The aim of this study was to investigate the association of functional variable number tandem repeat (VNTR) polymorphism rs58335419 locating in the upstream of the MIR137 gene with the risk of colon and gastric cancers. +circulation_biomarker_diagnosis_up 35996513 hsa-mir-206 Carotid Stenosis Conclusion: Serum miR-206 has high diagnostic accuracy for asymptomatic CAS and has predictive value for the incidence of CIEs in patients within 5 years. +transcription factor target 35996510 hsa-mir-640 Glioma These results suggest that miR-640 mediates the radiosensitivity of glioma cells through SLIT1 and the Wnt/beta-catenin signaling pathway. +other 35996508 hsa-mir-124-1 Endometriosis 1 rs531564, are linked to endometriosis. +other 35996508 hsa-mir-423 Endometriosis 1 rs531564, are linked to endometriosis. +other 35996508 hsa-mir-27a Endometriosis 1 rs531564, are linked to endometriosis. +circulation_biomarker_diagnosis_ns 35996507 hsa-mir-152 Diabetes Mellitus, Type 2 This hypothesised changes in the serum of miR-93 and miR-152 in diabetes and diabetic retinopathy. +circulation_biomarker_diagnosis_ns 35996507 hsa-mir-93 Diabetic Retinopathy This hypothesised changes in the serum of miR-93 and miR-152 in diabetes and diabetic retinopathy. +circulation_biomarker_diagnosis_ns 35996507 hsa-mir-93 Diabetes Mellitus, Type 2 This hypothesised changes in the serum of miR-93 and miR-152 in diabetes and diabetic retinopathy. +circulation_biomarker_diagnosis_ns 35996507 hsa-mir-152 Diabetic Retinopathy This hypothesised changes in the serum of miR-93 and miR-152 in diabetes and diabetic retinopathy. +lncRNA target 35996500 hsa-mir-650 Adenocarcinoma of Lung CARD8-AS1/miR-650 may serve as novel prognostic biomarkers and potential therapeutic targets for the treatment of lung adenocarcinoma. +lncRNA target 35996496 hsa-mir-1179 Carcinoma, Non-Small-Cell Lung Inhibited expression of LINC01929 significantly reduced the proliferation, migration, and invasion of NSCLC cells by targeting miR-1179. +circulation_biomarker_prognosis_ns 35996079 hsa-mir-130a Cerebrovascular Disorders CONCLUSION: All the findings indicated that high serum miR-130a-3p had diagnostic potential to screen cerebral AS, and predicted the probability of cerebrovascular events after AS. +circulation_biomarker_prognosis_ns 35996079 hsa-mir-130a Atherosclerosis CONCLUSION: All the findings indicated that high serum miR-130a-3p had diagnostic potential to screen cerebral AS, and predicted the probability of cerebrovascular events after AS. +circulation_biomarker_diagnosis_up 35995288 hsa-mir-21 Angelman Syndrome Our findings suggest that occupational noise exposure is positively associated with AS, and plasma miR-92a-3p and miR +circulation_biomarker_diagnosis_up 35995288 hsa-mir-92a Angelman Syndrome Our findings suggest that occupational noise exposure is positively associated with AS, and plasma miR-92a-3p and miR +transcription factor target 35995138 hsa-mir-143 Triple Negative Breast Neoplasms Previously, we demonstrated that adding targeting sequences (TS) of miR-145/143, which are downregulated in cancer compared with normal cells, into CVB3 genome drastically attenuates tissue toxicity, while retaining its oncolytic activity towards lung tumor. +transcription factor target 35995138 hsa-mir-145 Triple Negative Breast Neoplasms Previously, we demonstrated that adding targeting sequences (TS) of miR-145/143, which are downregulated in cancer compared with normal cells, into CVB3 genome drastically attenuates tissue toxicity, while retaining its oncolytic activity towards lung tumor. +other 35995115 hsa-mir-134 Hearing Loss, Unilateral 3p showed lower expressions in SSD rats than in control rats, which were 0.55-, 0.61-, and 0.69-fold lower, respectively (P < 0.05). +other 35995115 hsa-mir-425 Hearing Loss, Unilateral 3p showed lower expressions in SSD rats than in control rats, which were 0.55-, 0.61-, and 0.69-fold lower, respectively (P < 0.05). +other 35995115 hsa-mir-199a Hearing Loss, Unilateral 3p showed lower expressions in SSD rats than in control rats, which were 0.55-, 0.61-, and 0.69-fold lower, respectively (P < 0.05). +other 35994808 hsa-mir-205 Breast Neoplasms High miR-205 expression had a detrimental effect on BC patient outcome. +other 35994229 hsa-mir-1205 Glioma Circ_0001982 accelerates glioma progression by modulating the miR-1205/E2F1 axis. +circulation_biomarker_diagnosis_down 35994228 hsa-mir-210 Pneumonia In this study, expression of SNHG16 and microRNA (miR)-210 in pneumonia plasma samples (n = 56) and control samples (n = 60) was detected by RT-qPCR. +genetics_knock down_suppress 35994105 hsa-mir-30 Sepsis CONCLUSION: Knockdown of circ_0074371 ameliorated LPS-induced HK2 cells apoptosis, inflammation and oxidative stress via regulating miR5p/ELK1, opening a new window into the pathogenesis AKI. +genetics_knock down_suppress 35994105 hsa-mir-30 Acute Kidney Injury CONCLUSION: Knockdown of circ_0074371 ameliorated LPS-induced HK2 cells apoptosis, inflammation and oxidative stress via regulating miR5p/ELK1, opening a new window into the pathogenesis AKI. +lncRNA target 35993956 hsa-mir-1246 Squamous Cell Carcinoma of Head and Neck miR-1246 expression levels within clinical LSCC tissues and cell lines (TU212 and AMC-HN-8) were detected through quantitative reverse transcription polymerase chain reaction (qRT-PCR) assay. +lncRNA target 35993945 hsa-mir-455 Carcinoma, Squamous Cell, Cutaneous GAS5 suppresses cSCC cell proliferation, migration, and invasion by targeting the miR5p/CDKN1B axis. +transcription factor target 35993944 hsa-mir-532 Carcinoma, Non-Small-Cell Lung In summary, this study demonstrated the tumor-suppressive role of miR +genetics_overexpression_promote 35993943 hsa-mir-488 Pre-Eclampsia GATA3-AS1 is overexpressed in PE and promotes PE progression by the miR +lncRNA target 35993940 hsa-mir-98 Carcinoma, Non-Small-Cell Lung In conclusion, Linc00511 was elevated in NSCLC, which might participate NSCLC postoperative distant recurrence and promoted NSCLC cell proliferation, migration and invasion via targeting and regulating miR5p/TGFBR1 axis. +lncRNA target 35993694 hsa-mir-125a Angelman Syndrome But the roles of microRNA-125a-3p (miR-125a-3p) in the pathogenesis of AS remain unknown. miR-125a-3p aggravates the dysfunction of HUVECs induced by ox-LDL via BAMBI, which implies that miR-125a-3p is involved in the pathogenesis of AS. +other 35993468 hsa-mir-4316 psoriasis 1 5p and hsa-miR-4316 in the psoriasis group were significantly upregulated, indicating that they have potential value as biomarkers in psoriasis. +other 35993468 hsa-mir-194 psoriasis 1 5p and hsa-miR-4316 in the psoriasis group were significantly upregulated, indicating that they have potential value as biomarkers in psoriasis. +other 35993468 hsa-mir-612 psoriasis 1 5p and hsa-miR-4316 in the psoriasis group were significantly upregulated, indicating that they have potential value as biomarkers in psoriasis. +transcription factor target 35993414 hsa-mir-29a Inflammation Ingenuity Pathway Analysis on miR-29a and 34a targets was associated with inflammation through interleukins, TGFbeta and Notch genes, and p53 signaling. +lncRNA target 35993364 hsa-mir-149 Bisphosphonate-Associated Osteonecrosis Of The Jaw 5p on skeletal angiogenesis and bone remolding, suggesting it as a promising preventive and therapeutic target for BRONJ. +other 35993243 hsa-mir-127 Osteoarthritis CircSCAPER up-regulation in OA cartilages was discovered to be accompanied by decreased miR5p and increased TLR4. +circulation_biomarker_diagnosis_up 35993056 hsa-mir-497 Colorectal Neoplasms The serum levels of miR-497, CEA, CA24-2, and HBsAg were compared between 60 patients with CRC (observation group) and another 60 patients with colorectal polyps (control group). +other 35993042 hsa-mir-2467 Urinary Bladder Neoplasms 3p) sponge to control the expression of IQ motif containing GTPase activating protein 3 (IQGAP3) and cell division cycle associated 5 (CDCA5), resulting in activation of the rat sarcoma virus (Ras)/rapidly accelerated fibrosarcoma (Raf)/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) and PI3K/AKT/mTOR signaling pathways. +other 35993042 hsa-mir-4435-2 Urinary Bladder Neoplasms CONCLUSION: MIR4435-2HG involves in the progression of BCa, which might provide novel insights for BCa treatment. +other 35992914 hsa-mir-873a Osteochondrodysplasias 5p. +target gene 35992869 hsa-mir-26a Osteosarcoma LncRNA SCAMP1 disrupts the balance between miR-26a-5p and ZEB2 to promote osteosarcoma cell viability and invasion. +lncRNA target 35992812 hsa-mir-625 Endometrial Neoplasms We also showed that circ_0007534 enhanced endometrial cancer aggressiveness, progression, and paclitaxel resistance by sponging microRNA-625 (miR-625) and subsequently increasing the expression of the miR-625 target gene ZEB2. Targeting the circ_0007534/miR-625/ZEB2 pathway might be an effective strategy for overcoming paclitaxel resistance in endometrial cancer. +genetics_overexpression_promote 35992774 hsa-mir-429 Carcinoma, Endometrioid LINC01541 interacts with miR-429 to promote the expression of each other, and both inhibit the synthesis of VEGFA in EAC cells after overexpression. +other 35992658 hsa-mir-451a Inflammation CONCLUSION: MiR-451a correlates with the Th1/Th2 ratio, and they both relate to inflammation, septic organ injury, and mortality risk in patients with sepsis. +other 35992658 hsa-mir-451a Sepsis CONCLUSION: MiR-451a correlates with the Th1/Th2 ratio, and they both relate to inflammation, septic organ injury, and mortality risk in patients with sepsis. +lncRNA target 35992546 hsa-mir-497 Osteoarthritis Shortly, CircMELK promotes chondrocyte apoptosis and inhibits autophagy in OA by regulating MYD88/NF-kappaB signaling axis through miR +transcription factor target 35992541 hsa-mir-183 Sepsis 5p, which negatively modulated CTSB and Cur-mediated PI3K/AKT pathway via the miR +transcription factor target 35992154 hsa-mir-192 Diabetic Nephropathies We demonstrate a novel role for miR-192 in directly regulating KL levels, and through that, senescence and oxidative stress, key pathological processes in the development of DN. miR-192 and/or KL levels are altered with severity and duration of diabetes and could serve as early biomarkers for DN. +transcription factor target 35992154 hsa-mir-192 Diabetes Mellitus We demonstrate a novel role for miR-192 in directly regulating KL levels, and through that, senescence and oxidative stress, key pathological processes in the development of DN. miR-192 and/or KL levels are altered with severity and duration of diabetes and could serve as early biomarkers for DN. +transcription factor target 35992108 hsa-mir-148a Osteoporosis MiR-148a-3p was upregulated in subjects with acute SCI vs chronic SCI, as well as in acute SCI vs no SCI. Our findings suggest that miR-148a-3p is a mediator of osteoporosis following spinal cord injury and a potential future therapeutic target. +transcription factor target 35992108 hsa-mir-148a Spinal Cord Injuries MiR-148a-3p was upregulated in subjects with acute SCI vs chronic SCI, as well as in acute SCI vs no SCI. Our findings suggest that miR-148a-3p is a mediator of osteoporosis following spinal cord injury and a potential future therapeutic target. +circulation_biomarker_diagnosis_ns 35991513 hsa-mir-7 Carcinoma, Ovarian Epithelial In addition, in plasma of EOC patients, ciRS-7 negatively correlated with has-miR +transcription factor target 35991122 hsa-mir-181a Sepsis Our study indicated miR-181a-5p as a new potential therapeutic target for S-AKI therapy. +transcription factor target 35990993 hsa-mir-205 Nasopharyngeal Carcinoma 5p, thereby it inhibited NPC cell proliferation and metastasis and enhanced radiosensitivity. +genetics_overexpression_suppress 35990825 hsa-mir-216b Optic Neuritis In addition, overexpression of FAS exacerbated experimental optic neuritis by promoting the inflammatory response and Th17 cell differentiation, and miR-216b-5p reversed this effect. +lncRNA target 35990372 hsa-mir-655 Nasopharyngeal Neoplasms In addition, the increase of miR-655 may be a target for treating nasopharyngeal carcinoma. +other 35990342 hsa-mir-663a Carcinoma, Hepatocellular Transcriptome analysis of human hepatocellular carcinoma cells (HepG2) under leucine deprivation revealed that hsa-miR-663a and hsa-miR-1469 were altered in a transcription factor 4-dependent manner. +other 35990342 hsa-mir-1469 Carcinoma, Hepatocellular Transcriptome analysis of human hepatocellular carcinoma cells (HepG2) under leucine deprivation revealed that hsa-miR-663a and hsa-miR-1469 were altered in a transcription factor 4-dependent manner. +other 35989496 hsa-mir-1287 COVID-19 CONCLUSION: The results of this in-vitro and in silico study show that hsa_circ_0004812/hsa-miR5p/IL6R, RIG-I can play an important role in the outcome of COVID-19. +lncRNA target 35989413 hsa-mir-145a Spinal Cord Injuries Tug1 contributes NLRP3 inflammasome-dependent pyroptosis through miR-145a-5p/Tlr4 axis post-stroke, providing a promising therapeutic strategy against inflammatory injury. +genetics_GWAS 35989410 hsa-mir-373 Colorectal Neoplasms CONCLUSION: Considering the role of miR-31 and miR-373 in CRC tumor progression, it seems that the CRC patients bearing KRAS mutations have a poorer prognosis respective to patients without KRAS mutations. +genetics_GWAS 35989410 hsa-mir-1 Colorectal Neoplasms CONCLUSION: Considering the role of miR-31 and miR-373 in CRC tumor progression, it seems that the CRC patients bearing KRAS mutations have a poorer prognosis respective to patients without KRAS mutations. +genetics_overexpression_promote 35989156 hsa-mir-455 Osteosarcoma Likewise, overexpressing miR +transcription factor target 35988833 hsa-mir-149 Sepsis 5p may play a crucial role in vitamin-D inhibiting LPS/CLP induce ALI. +transcription factor target 35988833 hsa-mir-149 Acute Lung Injury 5p may play a crucial role in vitamin-D inhibiting LPS/CLP induce ALI. +other 35988655 hsa-mir-22 Osteoporosis, Postmenopausal The results showed that the expression profiles of lncRNAs could help identify the novel ones involved in the progression of PMOP, and that MIR22HG could serve as a miRNA precursor to regulate FoxO signaling pathway in bone metabolism. +lncRNA target 35988424 hsa-mir-377 Osteoarthritis Therefore, we concluded that ABPS could inhibit thapsigargin (TG)-induced chondrocyte ERS through the lncRNA NEAT1/miR +other 35988346 hsa-mir-143 Prostatic Neoplasms miRNA-143 is reported to be associated with the development of prostate cancer. +circulation_biomarker_diagnosis_up 35988281 hsa-mir-214 Heart Failure 3p) on sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase 2a (SERCA2a) and its mechanism on heart failure (HF). +circulation_biomarker_diagnosis_ns 35988268 hsa-mir-21 Heart Neoplasms In this study, miR-21 has an oncogenic role that can be measured in patients' serum to assess the progression of gastric cancer. +lncRNA target 35988105 hsa-mir-206 Uveomeningoencephalitic Syndrome Furthermore, we mapped a network of competing endogenous RNAs for hsa-miR-206, which we used to identify putative targets for VKH treatment. +exosome 35988100 hsa-mir-625 Lung Neoplasms Basing on the results from miRNA sequencing, qRT-PCR and wound healing assay, hsa-miR3p was discovered to be accumulated inside hypoxic exosomes and responsible for the metastasis of lung cancer cell. +lncRNA target 35987939 hsa-mir-29 Neoplasms, Multiple Primary Dysregulation of programs associated with >80 RNA-binding proteins (RBPs) and microRNAs (miRNAs) drive these changes, including multi-cancer inactivation of RBFOX and miR-29 families. +exosome 35987860 hsa-mir-21 Polycystic Ovary Syndrome AMSC-EXOs inhibited the expression of B-cell translocation gene 2 by transferring miR5p to the livers of rats with PCOS, thus activating the IRS1/AKT pathway and increasing hepatic metabolism. +other 35987859 hsa-mir-24 Carcinoma, Hepatocellular We detected that high expression of miR-24, miR-10b and the low expression of miR-143 were independently and significantly associated with HCC in AFP-stable compared with AFP trending (P < .05). CONCLUSIONS: Although more clinical validations are needed for the diagnosis of HCC, our current results indicate that the coexistence of high expression of miR-10b and miR-24 may help clinicians adjust in the diagnosis of HCC in patients who are on the liver transplant list but awaiting biopsy for the diagnosis of HCC. +genetics_overexpression_promote 35987744 hsa-mir-182 Keloid 5p enrichment also blocked keloid fibroblast proliferation, survival and migration, while further ZNF217 overexpression abolished these effects. +exosome 35987145 hsa-mir-146b Osteoarthritis According to miRNA sequencing analysis of these exosomes and subsequent target activity assays, we confirmed DIG controls OA inflammatory microenvironment and promotes chondrogenesis by, at least partly, downregulating the M1-like macrophage-derived exosomal miR-146b-5p/Usp3&Sox5 axis in vitro and in vivo. +circRNA target 35987088 hsa-mir-198 Stomach Neoplasms Collectively, our work suggests that the Exo-mediated transfer of circ_0038138 potentially facilitates the glycolysis, growth and metastasis of GAC cells via miR-198/EZH2 axis, which offers a potential prognostic marker and a therapeutic target for GAC. +circulation_biomarker_diagnosis_ns 35986985 hsa-mir-21 Breast Neoplasms This approach further detects circulating ExoPD-L1 and ExomiR-21 in human plasma to differentiate breast cancer patients from healthy individuals with high accuracy, showing great potential of DCNPs for simultaneous profiling exosomal surface and inside biomarkers, and for clinical precision diagnosis. +other 35986741 hsa-mir-518a Breast Neoplasms An in-depth understanding of the role of the miR-518a-5p in BC can help clinicians to understand the pathogenic mechanism of breast cancer more accurately. +other 35986538 hsa-mir-130a Colorectal Neoplasms In addition, a few miRNAs (miR-27a-3p and miR-130a-3p) and drugs (triclosan, soman, reserpine, and isoproterenol, etc.) were found capable to alter the expression of hub genes and thus need to further be evaluated for their potential role in CRC treatment. +other 35986538 hsa-mir-27a Colorectal Neoplasms In addition, a few miRNAs (miR-27a-3p and miR-130a-3p) and drugs (triclosan, soman, reserpine, and isoproterenol, etc.) were found capable to alter the expression of hub genes and thus need to further be evaluated for their potential role in CRC treatment. +lncRNA target 35986526 hsa-mir-137 Esophageal Squamous Cell Carcinoma CONCLUSION: These findings have uncovered the new function of miR-137 in ESCC via negatively regulating DAAM1, suggesting miR-137 as a potent therapeutic candidate for ESCC treatment. +lncRNA target 35986524 hsa-mir-490 Myocardial Infarction 3p alleviates cardiomyocyte injury via targeting FOXO1 in MI. +genetics_overexpression_promote 35986524 hsa-mir-490 Cardiomyopathy, Hypertrophic 3p overexpression inhibited HCM cell inflammatory responses and injury after hypoxia treatment. +other 35986524 hsa-mir-490 Cardiovascular Diseases 3p) plays a role in the pathogeneses of a variety of cardiovascular diseases. +target gene 35986482 hsa-mir-200a Glucose Metabolism Disorders Meanwhile, melatonin effectively inhibited miR-200a-3p and glucose metabolism disorder. +circulation_biomarker_diagnosis_up 35986376 hsa-mir-142 Rotator Cuff Injuries RESULTS: Circulating exosomal miRNAs sequencing showed that, compared to exosomes from patients without adhesive capsulitis, miR-142 was significantly up-regulated in exosomes from adhesive capsulitis (Exo-S). +other 35986343 hsa-mir-548s Carcinoma, Hepatocellular CONCLUSION: LncMMPA plays an important role in regulating HCC malignancy and metabolic reprogramming of miR-548 s/ALDH1A3 pathway. +genetics_overexpression_promote 35986311 hsa-mir-29b Leukemia, Myeloid, Acute When miR-29b-3p was overexpressed in AML cells, HuR was down-regulated, accompanied by cell viability decreased, cell cycle arrest, apoptosis increased, invasion and migration weakened. +circulation_biomarker_diagnosis_up 35986010 hsa-mir-155 Glioma 5p in plasma exosomes from patients was associated with glioma diagnosis and grading. +lncRNA target 35985609 hsa-mir-21 Leukoencephalopathies 5p agomir inhibited the mRNA and protein expression of PTEN, increased p-Akt phosphorylation, and decreased the expression and activation of related apoptotic proteins.On the other hand, the administration of miR +target gene 35985238 hsa-mir-548d Stomach Neoplasms LncRNA TPTEP1 inhibits the migration and invasion of gastric cancer cells through miR-548d-3p/KLF9/PER1 axis. +lncRNA target 35985237 hsa-mir-1307 Carcinoma, Hepatocellular Targeting a vicious feedback loop between HIF-1alpha/miR +genetics_overexpression_promote 35985176 hsa-mir-494 Triple Negative Breast Neoplasms Finally, in a xenograft model, both miR-494 overexpression and the HIF-1alpha inhibitor PX-478 increased the sensitivity of TNBC to DTX by suppressing the HIF-1alpha/miR-494/Survivin signaling pathway in vivo. +genetics_GWAS 35984881 hsa-mir-501 Schizophrenia The epigenetic and pathophysiological mechanism that links miR +genetics_knock down_promote 35984862 hsa-mir-2 Parkinson Disease In support of this, we demonstrated that RNAi knockdown of multiple mir-2 targets enhanced alpha-syn-induced DA neurodegeneration. +exosome 35984761 hsa-mir-25 Substance Abuse, Intravenous Extracellular vesicles derived from PRP containing miR3p may be a new method for IVD treatment. +genetics_overexpression_promote 35984761 hsa-mir-25 Nerve Degeneration 3p or overexpressing SOX4 or CXCR7 reversed the alleviating role of PRP-EVs in NP cell degeneration. +genetics_overexpression_promote 35984761 hsa-mir-25 Niemann-Pick Diseases 3p or overexpressing SOX4 or CXCR7 reversed the alleviating role of PRP-EVs in NP cell degeneration. +lncRNA target 35984706 hsa-mir-199a Myocardial Reperfusion Injury This study was to probe the role of penehyclidine hydrochloride (PHC) mediating the impact of toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)/nuclear factor-kappa B (NF-kappaB) signalling pathway on myocardial ischaemia-reperfusion injury (MI/RI) in rats through miR-199a-3p. In conclusion, PHC suppresses TLR4/MyD88/NF-kappaB signalling pathway through miR-199a-3p, thereby improving MI/RI in rats. +epigenetics 35984699 hsa-mir-4717 Colorectal Neoplasms Furthermore, we confirmed that methyltransferase-like 3 (METTL3)-dependent m(6) A methylation could methylate primary (pri)-miR-4717, which further promoted the maturation of pri-miR-4717, and METTL3 positively regulated CRC cell proliferation through miR-4717/MAP2K4 pathways. +lncRNA target 35984595 hsa-mir-148a Fibrosis, Atrial Collectively, Sal B can protect the Ang II-activated FBs from fibrosis and oxidative stress via AMPK/FoxO1/miRNA-148a-3p axis. +genetics_knock down_promote 35984539 hsa-mir-633 Arthritis, Rheumatoid TRAF6 was a direct target of miR-633, and miR-633 overexpression suppressed the aggressive changes of RA-FLSs by down-regulating TRAF6. +target gene 35984538 hsa-mir-640 Glioblastoma MicroRNA-640 Inhibition Enhances the Chemosensitivity of Human Glioblastoma Cells to Temozolomide by Targeting Bcl2 Modifying Factor. +other 35984199 hsa-mir-509 Osteosarcoma Our study suggests that miR-509 may serve as a potential biomarker for evaluating OS prognosis and provides clues for tailoring OS immunotherapy strategies. +other 35984198 hsa-mir-21 lung squamous cell carcinoma 3p. +other 35984198 hsa-mir-650 lung squamous cell carcinoma 3p. +other 35984198 hsa-mir-4689 lung squamous cell carcinoma 3p. +other 35984198 hsa-mir-744 lung squamous cell carcinoma 3p. +other 35983819 hsa-let-7c Prostatic Neoplasms RESULTS: In our study, hsa-let7c-3p significantly 1,52 (p=0.018) and 1,84 (p=0.0095) fold down- regulated whereas, miR3p was significantly 2,36 (p=0.0006) and 2,24 (p=0.001) fold upregulated in the prostate cancer patients compared to benign prostate hyperplasia in group 1 and 2, respectively. +other 35983819 hsa-mir-143 Prostatic Neoplasms CONCLUSIONS: For the first time, we reported significantly altered expression levels of miRNAs (miR-let7c, miR221, miR-146a, miR-141, miR-143, miR17) and correlations between Treg marker FOXP3 in the aggressive prostate cancer patients suggesting that prostate cancer progression might be under the regulation of crosstalk between Tregs and miRNAs. +other 35983819 hsa-mir-141 Prostatic Neoplasms RESULTS: In our study, hsa-let7c-3p significantly 1,52 (p=0.018) and 1,84 (p=0.0095) fold down- regulated whereas, miR3p was significantly 2,36 (p=0.0006) and 2,24 (p=0.001) fold upregulated in the prostate cancer patients compared to benign prostate hyperplasia in group 1 and 2, respectively. +other 35983819 hsa-mir-146a Prostatic Neoplasms CONCLUSIONS: For the first time, we reported significantly altered expression levels of miRNAs (miR-let7c, miR221, miR-146a, miR-141, miR-143, miR17) and correlations between Treg marker FOXP3 in the aggressive prostate cancer patients suggesting that prostate cancer progression might be under the regulation of crosstalk between Tregs and miRNAs. +other 35983819 hsa-mir-17 Prostatic Neoplasms CONCLUSIONS: For the first time, we reported significantly altered expression levels of miRNAs (miR-let7c, miR221, miR-146a, miR-141, miR-143, miR17) and correlations between Treg marker FOXP3 in the aggressive prostate cancer patients suggesting that prostate cancer progression might be under the regulation of crosstalk between Tregs and miRNAs. +other 35983819 hsa-mir-221 Prostatic Neoplasms CONCLUSIONS: For the first time, we reported significantly altered expression levels of miRNAs (miR-let7c, miR221, miR-146a, miR-141, miR-143, miR17) and correlations between Treg marker FOXP3 in the aggressive prostate cancer patients suggesting that prostate cancer progression might be under the regulation of crosstalk between Tregs and miRNAs. +lncRNA target 35983126 hsa-mir-205 Melanoma We demonstrated that SNHG16 promotes the metastasis and growth of melanoma through miR5p/PAK2 axis. +genetics_knock down_promote 35983051 hsa-mir-223 Mucocutaneous Lymph Node Syndrome CONCLUSIONS: The horizontal transfer of platelet-derived miR-223 suppresses the expression of ICAM-1 in HCAECs, which at least in part attenuates leukocyte adhesion, thereby reducing endothelial damage in KD vasculitis. +genetics_knock down_suppress 35982896 hsa-mir-138 Osteoporosis 5p in aging-related bone loss and may provide a powerful therapeutic target for ameliorating senile osteoporosis. +circulation_biomarker_diagnosis_ns 35982888 hsa-mir-370 Glioblastoma 3p/ TGFBR2 and thus may be a potential serum biomarker of GBM. +lncRNA target 35982887 hsa-mir-520h Urinary Bladder Neoplasms Conclusions: Our research revealed that nitroxoline may suppress metastasis in bladder cancer via EGR1/circNDRG1/miR-520h/smad7/EMT signaling pathway. +other 35981627 hsa-mir-146a Neurodegenerative Diseases CONCLUSIONS: Cel exerts neuroprotective activity against 6-OHDA-caused neurotoxicity by regulating miR-146a/PI3K/Akt/mTOR pathway, which provides a potential application of Cel for treating neurodegenerative diseases. +other 35981627 hsa-mir-146a Neurotoxicity Syndromes Moreover, a miR-146a mimic was synthesized and transfected into PC12 cells to further determine the mechanisms of Cel's neuronal protection against 6-OHDA-induced neurotoxicity. CONCLUSIONS: Cel exerts neuroprotective activity against 6-OHDA-caused neurotoxicity by regulating miR-146a/PI3K/Akt/mTOR pathway, which provides a potential application of Cel for treating neurodegenerative diseases. +genetics_overexpression_promote 35981137 hsa-mir-27a Leukemia Consequent to AF4 and MLL-AF4 downregulation, MiR-27a overexpression negatively affects transcription of HOXA9 and MEIS1 in different t(4;11) leukemia cell lines. +genetics_knock down_promote 35981103 hsa-mir-124 Glioma 3p or knockdown of CREBRF enhanced apoptosis and autophagy and diminished proliferation of glioma cells. +genetics_overexpression_suppress 35980563 hsa-mir-214 Hypoxia-Ischemia, Brain 3p and overexpressing TXNIP reversed the therapeutic effect of miR +transcription factor target 35980523 hsa-mir-21 salivary gland mucoepidermoid carcinoma Increased expression of miR-21 (p < 0.001) and decreased expression of miR-145 (p < 0.001) were observed in MECs compared to normal salivary gland tissue. CONCLUSION: Our results support the tumor suppressor role of miR-145 and the oncogenic role of miR-21 in salivary gland MEC. +transcription factor target 35980523 hsa-mir-145 salivary gland mucoepidermoid carcinoma Increased expression of miR-21 (p < 0.001) and decreased expression of miR-145 (p < 0.001) were observed in MECs compared to normal salivary gland tissue. CONCLUSION: Our results support the tumor suppressor role of miR-145 and the oncogenic role of miR-21 in salivary gland MEC. +exosome 35980503 hsa-mir-135a Carcinoma, Non-Small-Cell Lung It was found that cancer cell-derived exosomal LINC00313 promoted M2 macrophage differentiation in NSCLC by up-regulating STAT6 as miR-135a-3p sponge. +genetics_knock down_suppress 35980117 hsa-mir-582 Leukemia, Myeloid, Acute 3p inhibition ameliorated the impacts of circPTK2 knockdown on AML cell processes. +transcription factor target 35980063 hsa-mir-153 Nervous System Diseases Given the growing interest in miR-153 as a biomarker and therapeutic target for neurological diseases as well as the lack of comprehensive investigation of miR-153 function in these disorders, it is necessary to identify the downstream and upstream targets and also it's potential as a therapeutic biomarker target. +genetics_overexpression_promote 35979756 hsa-mir-20b Leukemia, Promyelocytic, Acute Moreover, miR-320a/b upregulation promoted cell cycle arrest in the G1 phase and suppressed the viability of APL cells, and the impacts were reversed by ARNTL overexpression. In conclusion, miR-320a/b suppresses cell viability and leads to cell cycle arrest by suppressing ARNTL in APL. +genetics_overexpression_promote 35979756 hsa-mir-20a Leukemia, Promyelocytic, Acute Moreover, miR-320a/b upregulation promoted cell cycle arrest in the G1 phase and suppressed the viability of APL cells, and the impacts were reversed by ARNTL overexpression. In conclusion, miR-320a/b suppresses cell viability and leads to cell cycle arrest by suppressing ARNTL in APL. +other 35979583 hsa-mir-22 High Pressure Neurological Syndrome 3p was extensively expressed in dental pulp cells. +other 35979583 hsa-mir-22 Pulpitis AIM: To investigate the synergetic regulatory effect of miR-22 on HIF-1alpha and NLRP3, subsequently regulating the production of the NLRP3/CASP1 inflammasome pathway-mediated proinflammatory cytokines IL-1beta and IL-18 in human dental pulp fibroblasts (HDPFs) during the progression of pulpitis. RESULTS: A decrease in miR-22 and an increase in HIF-1alpha and NLRP3 in HDPTs occurred during the transformation of reversible pulpitis into irreversible pulpitis compared with that in the healthy pulp tissues (p < .05). +circRNA target 35979014 hsa-mir-1 Sepsis Induced Liver Injury CONCLUSION: Taken together, circ-Katnal1 enhanced inflammatory pyroptosis in sepsis-induced liver injury through the miR5p/GSDMD axis. +genetics_overexpression_suppress 35978929 hsa-mir-374a Acute Lung Injury In addition, ZEB1 was revealed to be a downstream target of miR-374a-5p, and overexpression of ZEB1 could reverse the anti-apoptotic and anti-inflammatory effects of miR-374a-5p on an LPS-induced sepsis cell model. +genetics_overexpression_promote 35978818 hsa-mir-124 Cholangiocarcinoma 5p was upregulated in serum exosomes from CHOL patients and exosomes from CHOL cells, and overexpression of miR +target gene 35978816 hsa-mir-24-1 Carcinoma, Renal Cell FBP1 /miR-24-1/enhancer axis activation blocks renal cell carcinoma progression via Warburg effect. +epigenetics 35978806 hsa-mir-27a Breast Neoplasms MiR-27a-3p binds to TET1 mediated DNA demethylation of ADCY6 regulates breast cancer progression via epithelial-mesenchymal transition. +other 35978628 hsa-mir-212 Otitis Media The mRNA and protein expression levels of hsa-miR5p, type 1 cannabinoid receptor (CNR1), alkaline phosphatase (ALP), Runx2, osteocalcin (OCN), and collagen 1 A1 (COL1A1) in the OM and PRP groups were detected by qRT-PCR and Western blot analyses. +lncRNA target 35978508 hsa-let-7 Atherosclerosis Recently, studies have reported that the RNA binding protein Lin28b directly regulates the let-7 microRNA (miRNA), which participates in the process of atherosclerosis (AS) by regulating inflammation. Taken together, these findings indicate that Sirt6 inhibits vascular endothelial cell pyroptosis by negatively regulating the Lin28b/let-7 pathway in AS. +genetics_overexpression_suppress 35978504 hsa-mir-548d Osteoarthritis Furthermore, miR-548d-5p overexpression partially reversed papain-induced damages on OA rat's knee articular cartilage. +circRNA target 35978501 hsa-mir-940 Inflammation RESULTS: Circ_0128846 and PTPN12 expression were significantly upregulated, whereas miR-940 was downregulated in the cartilage tissues of OA patients and IL-1beta-treated C28/I2 cells compared with controls. CONCLUSION: Circ_0128846 regulated human chondrocyte proliferation, apoptosis and inflammation through the miR-940/PTPN12 pathway in OA. +exosome 35978499 hsa-mir-223 Myocarditis We probed into the mechanisms of MSC-EV-enclosed miR +exosome 35978499 hsa-mir-223 Syphilis We probed into the mechanisms of MSC-EV-enclosed miR +other 35978360 hsa-mir-3976 Carcinoma, Hepatocellular The aim of this study was to explore the relationship between rs6757 and the HCC risk in the South Chinese population, and the functional significance of rs6757 by affecting the efficacy of microRNA-3976 (miR-3976) binding to the CD147 3'-UTR. +genetics_knock down_promote 35978328 hsa-mir-215 Osteoporosis Functional loss and acquisition experiments depicted that miR +circulation_biomarker_diagnosis_up 35978298 hsa-mir-148b Diabetes Mellitus, Type 2 METHODS: We evaluated the expression of miR-148b-3p and miR-27a-3p in the plasma of three groups: 20 prediabetic patients, 20 T2D patients, and 20 healthy controls. +lncRNA target 35978049 hsa-mir-622 Colorectal Neoplasms In conclusion, the present study indicates that SP100-AS1/miR-622/ATG3 axis contributes to radioresistance and autophagic activity in CRC patients, suggesting it has huge prospects as a therapeutic target for improving CRC response to radiation therapy. +transcription factor target 35977804 hsa-mir-34 Endometriosis 3p as a potential therapeutic target in endometriosis. +transcription factor target 35977075 hsa-mir-135a Sepsis CONCLUSIONS: Our study suggested that the protective effect of miR-135a inhibitor on LPS-induced THP-1 cells injury was realized by regulation of MYOM1, which might afford a pair of novel molecules for sepsis clinical diagnosis. +transcription factor target 35977046 hsa-mir-520c Carcinoma, Non-Small-Cell Lung Considering the critical role of sphingolipids in NSCLC, our study advocates the target CERS6 which can be potentially inhibited using hsa-miR-520c-3p to combat NSCLC for future precision medicine. +genetics_knock down_suppress 35976517 hsa-mir-140 Acute Kidney Injury CircZNF644 knockdown protected HK-2 cells from LPS-induced injury by altering miR5p/MLKL pathway, suggesting that circZNF644 may be a hopeful therapeutic target for AKI. +lncRNA target 35976514 hsa-mir-548 Stomach Neoplasms Inhibition of miR-548 might be a novel therapeutic strategy for gastric cancer. +genetics_overexpression_promote 35976474 hsa-mir-339 Nasopharyngeal Carcinoma 3p overexpression inhibited NPC tumor growth in vivo. +exosome 35976364 hsa-mir-181c Neuralgia Here we investigated the therapeutic effect of exosomal miR-181c-5p (ExomiR-181c-5p) on a rat model of neuropathic pain induced by sciatic nerve chronic constriction injury (CCI). +other 35976169 hsa-mir-192 Diabetic Nephropathies 5p are associated with the development of DN and may be potential biomarkers for the early diagnosis of DN. +genetics_overexpression_promote 35975858 hsa-mir-299 Squamous Cell Carcinoma of Head and Neck Moreover, FOXN3 overexpression partially reversed the promoting effects of miR +genetics_knock down_suppress 35975639 hsa-mir-588 Stomach Neoplasms CONCLUSIONS: circ-LDLRAD3 knockdown reduced DDP resistance and blocked the malignant development of DDP-resistant GC by modulating the miR-588/SOX5 pathway. +circulation_biomarker_diagnosis_ns 35975539 hsa-mir-326 Polycystic Ovary Syndrome CONCLUSIONS: The study showed that serum miR-184 and miR-326 are highly expressed in PCOS patients and can be used as molecular biomarkers for PCOS diagnosis. +circulation_biomarker_diagnosis_ns 35975539 hsa-mir-184 Polycystic Ovary Syndrome CONCLUSIONS: The study showed that serum miR-184 and miR-326 are highly expressed in PCOS patients and can be used as molecular biomarkers for PCOS diagnosis. +circulation_biomarker_prognosis_ns 35975537 hsa-mir-221 Diabetes, Gestational The high expression of miR-221 and miR-320 in the peripheral plasma of pregnant women may directly or indirectly participate in the occurrence and development of GDM or may become a new target for the diagnosis, treatment, and prognosis of GDM. +circulation_biomarker_prognosis_ns 35975537 hsa-mir-20 Diabetes, Gestational The high expression of miR-221 and miR-320 in the peripheral plasma of pregnant women may directly or indirectly participate in the occurrence and development of GDM or may become a new target for the diagnosis, treatment, and prognosis of GDM. +lncRNA target 35975534 hsa-mir-155 Thrombocytopenia The interaction network of core downstream target genes and ITP differentially expressed genes of miR-21 and miR-155 were constructed with the STRING database, and the associated factors were verified by qPCR. +other 35975529 hsa-mir-126 Pulmonary Embolism CONCLUSIONS: Lower levels of miRNA-145 and higher levels of miRNA-126 associated with worse diagnosis PE in patients with COPD. +other 35975529 hsa-mir-126 Pulmonary Disease, Chronic Obstructive CONCLUSIONS: Lower levels of miRNA-145 and higher levels of miRNA-126 associated with worse diagnosis PE in patients with COPD. +other 35975488 hsa-mir-641 Ischemic Stroke In the study, we aimed to study the role and underlying mechanism of miR-641 in ischemic stroke. CONCLUSIONS: MiR-641 may be a novel therapeutic agent for ischemic stroke by modulating the MCL-1/Wnt/beta-catenin axis on neuronal damage in brain tissue in the ischemic region after ischemic stroke. +circulation_biomarker_diagnosis_up 35975247 hsa-mir-222 Polycystic Ovary Syndrome Circulating miR-132, miR-146a and miR-222 levels were significantly downregulated in the PCOS group compared with the control group. +circulation_biomarker_diagnosis_up 35975247 hsa-mir-132 Polycystic Ovary Syndrome Circulating miR-132, miR-146a and miR-222 levels were significantly downregulated in the PCOS group compared with the control group. +circulation_biomarker_diagnosis_up 35975247 hsa-mir-146a Polycystic Ovary Syndrome Circulating miR-132, miR-146a and miR-222 levels were significantly downregulated in the PCOS group compared with the control group. +transcription factor target 35975203 hsa-mir-1290 Colorectal Neoplasms We demonstrated that miR-1290 enhanced proliferation, migration, and angiogenesis partially through suppression of THBS1, DKK3, and SCAI in CRC. +exosome 35974445 hsa-mir-518c Short Stature, Idiopathic, Autosomal CONCLUSIONS: The authors identified a novel pathogenesis in ISS that exosome-derived hsa_circ_0063476 retards the expression of markers of endochondral ossification and impairs longitudinal bone growth via miR-518c-3p/DDX6 axis, which may provide a unique therapeutic avenue for ISS. +genetics_overexpression_promote 35974419 hsa-mir-148a Carcinoma, Non-Small-Cell Lung When miR-148a-3p was overexpressed, this reversed the impact of knocking down circ_0009043 on the apoptotic death and proliferation of NSCLC cells. +genetics_overexpression_promote 35974258 hsa-mir-222 Pancreatic Carcinoma 3p overexpressing M2 MDEs were treated with gemcitabine and co-cultured with PCa cells for in vitro experiments. +transcription factor target 35974199 hsa-mir-155 Breast Neoplasms Achieving the early diagnosis of breast cancer, through ultrasensitive detection of tumor marker miRNA-155, is a significant challenge. +lncRNA target 35972581 hsa-mir-29c Carcinoma, Non-Small-Cell Lung Moreover, RP11-79H23.3 siRNA facilitated the progression of NSCLC partially via regulating the expression of miR-29c and the activation of Wnt/beta-catenin signaling pathway. +transcription factor target 35972577 hsa-mir-210 Lung Neoplasms 3p modulated CELF2 expression, thus affecting cell phenotypes and cell cycle distribution in LUSC through PI3K/AKT pathway. +target gene 35972306 hsa-mir-196a Thyroid Neoplasms LncRNA-IQCH-AS1 sensitizes thyroid cancer cells to doxorubicin via modulating the miR-196a-5p/PPP2R1B signalling pathway. +other 35971931 hsa-let-7d Obesity INTRODUCTION: The aim of this is study was to analyse the expression of miR-193b, miR-378, miR-Let7-d, and miR-222 in human visceral adipose tissue (VAT), as well as their association with obesity, insulin resistance (IR), and their role in the regulation of genes controlling adipose tissue homeostasis, including adipocytokines, the phosphatase and tension homologue (PTEN), and tumour protein 53 (p53). +other 35971931 hsa-mir-193b Insulin Resistance INTRODUCTION: The aim of this is study was to analyse the expression of miR-193b, miR-378, miR-Let7-d, and miR-222 in human visceral adipose tissue (VAT), as well as their association with obesity, insulin resistance (IR), and their role in the regulation of genes controlling adipose tissue homeostasis, including adipocytokines, the phosphatase and tension homologue (PTEN), and tumour protein 53 (p53). +other 35971931 hsa-mir-193b Obesity INTRODUCTION: The aim of this is study was to analyse the expression of miR-193b, miR-378, miR-Let7-d, and miR-222 in human visceral adipose tissue (VAT), as well as their association with obesity, insulin resistance (IR), and their role in the regulation of genes controlling adipose tissue homeostasis, including adipocytokines, the phosphatase and tension homologue (PTEN), and tumour protein 53 (p53). +other 35971931 hsa-mir-222 Insulin Resistance CONCLUSIONS: Lower miR-222 levels are associated with IR, and PTEN and p53 expression; the implication of these genes in adipose tissue homeostasis needs more research. +other 35971931 hsa-mir-222 Werner Syndrome mRNA expression of PTEN and p53 was lower in OW/OB subjects with and without IR, compared to NW group and its levels positively associated with miR-222. +other 35971931 hsa-mir-222 Obesity INTRODUCTION: The aim of this is study was to analyse the expression of miR-193b, miR-378, miR-Let7-d, and miR-222 in human visceral adipose tissue (VAT), as well as their association with obesity, insulin resistance (IR), and their role in the regulation of genes controlling adipose tissue homeostasis, including adipocytokines, the phosphatase and tension homologue (PTEN), and tumour protein 53 (p53). +other 35971931 hsa-mir-378 Insulin Resistance INTRODUCTION: The aim of this is study was to analyse the expression of miR-193b, miR-378, miR-Let7-d, and miR-222 in human visceral adipose tissue (VAT), as well as their association with obesity, insulin resistance (IR), and their role in the regulation of genes controlling adipose tissue homeostasis, including adipocytokines, the phosphatase and tension homologue (PTEN), and tumour protein 53 (p53). RESULTS: miR-222 was lower in IR subjects, and miR-222 and miR-378 negatively correlated with HOMA-IR. +other 35971931 hsa-let-7d Insulin Resistance INTRODUCTION: The aim of this is study was to analyse the expression of miR-193b, miR-378, miR-Let7-d, and miR-222 in human visceral adipose tissue (VAT), as well as their association with obesity, insulin resistance (IR), and their role in the regulation of genes controlling adipose tissue homeostasis, including adipocytokines, the phosphatase and tension homologue (PTEN), and tumour protein 53 (p53). +other 35971931 hsa-mir-378 Obesity INTRODUCTION: The aim of this is study was to analyse the expression of miR-193b, miR-378, miR-Let7-d, and miR-222 in human visceral adipose tissue (VAT), as well as their association with obesity, insulin resistance (IR), and their role in the regulation of genes controlling adipose tissue homeostasis, including adipocytokines, the phosphatase and tension homologue (PTEN), and tumour protein 53 (p53). +other 35971848 hsa-mir-126 Asthma 5p, can be used as clinically relevant non-invasive biomarkers of the phenotype/endotype and severity of asthma. +other 35971848 hsa-mir-16 Asthma All of them, except miR5p were upregulated in MSA patients compared to MA. +other 35971848 hsa-mir-146a Asthma 5p, can be used as clinically relevant non-invasive biomarkers of the phenotype/endotype and severity of asthma. +other 35971848 hsa-mir-215 Asthma 5p, can be used as clinically relevant non-invasive biomarkers of the phenotype/endotype and severity of asthma. +other 35971848 hsa-mir-21 Asthma 5p, can be used as clinically relevant non-invasive biomarkers of the phenotype/endotype and severity of asthma. +lncRNA target 35971776 hsa-mir-7002 Fanconi Syndrome These results demonstrated that HG-exo carries excessive miR5p and inhibits autophagy through targeting Atg9b; this process then induces renal tubular dysfunction and inflammation. +lncRNA target 35971776 hsa-mir-7002 Inflammation These results demonstrated that HG-exo carries excessive miR5p and inhibits autophagy through targeting Atg9b; this process then induces renal tubular dysfunction and inflammation. +circRNA target 35971749 hsa-mir-885 Squamous Cell Carcinoma of Head and Neck Collectively, circSERPINA3 promotes proliferation, migration, and invasion of LSCC cells by targeting miR +other 35971429 hsa-mir-190 Insulinoma Taken together, our findings suggest that the miR-190/Cybb axis plays an important role in glucotoxicity-induced pancreatic beta-cell failure. +other 35971429 hsa-mir-190 Diabetes Mellitus, Type 2 Restoring miR-190 expression levels may be a possible therapeutic strategy to protect beta-cells in T2DM. +other 35971429 hsa-mir-190 Pancreatic Diseases Taken together, our findings suggest that the miR-190/Cybb axis plays an important role in glucotoxicity-induced pancreatic beta-cell failure. +lncRNA target 35971175 hsa-mir-122 Infertility, Male 5p) showing consistent dysregulation in infertility across a minimum of four studies. +lncRNA target 35971159 hsa-mir-216b Esophageal Squamous Cell Carcinoma LIPH-4 played an oncogenic role in ESCC through the miR-216b/IGF2BP2 axis. CONCLUSIONS: This study suggested that LIPH-4 functions as a novel oncogenic lncRNA by acting as a ceRNA for miR-216b to regulate IGF2BP2, indicating LIPH-4 likely constitutes a prognostic biomarker and therapeutic target in ESCC. +genetics_knock down_promote 35970794 hsa-mir-17 Multiple Myeloma After over expression or knockdown of miR +transcription factor target 35970246 hsa-mir-138 Prostatic Neoplasms 5p targeted and partially neutralized the role of WWC1 in Pca cells. +lncRNA target 35970245 hsa-mir-1229 Stomach Neoplasms Circ_0005758 acts as a tumor suppressor to impede gastric cancer progression via miR3p/GCNT4 axis, implying that therapeutic targeting of circ_0005758 may better to prevent gastric cancer. +lncRNA target 35970002 hsa-mir-1271 Endometriosis miR-1271 and its direct target gene, GRB2 (growth factor receptor-bound protein 2), expression have been studied in gynecologic cancers, while their role in endometriosis has not been studied. +genetics_overexpression_suppress 35969184 hsa-mir-499 Behcet Syndrome 5p overexpression contributes to dendritic impairments, deregulated calcium homeostasis, and neurocognitive dysfunction in BD. +transcription factor target 35969018 hsa-mir-320c Norrie disease Our study proposed to investigate the miR-320c expression and its function on the pathogenesis of DN in vitro. Therefore, inhibition of miR-320c could alleviate toxicity of HK-2 cells induced by HG via targeting PTEN and restraining the PI3K/AKT pathway, illustrating that miR-320c may act as a new biomarker in the diagnosis of DN. +genetics_overexpression_promote 35969010 hsa-mir-192 Stomach Neoplasms 5p was overexpressed in tumour and was associated with poor prognosis in GC. +genetics_overexpression_promote 35968984 hsa-mir-145 Breast Neoplasms To conclude, p53-induced activation of miR-145 could be inhibited by CCAT2, while overexpression of CCAT2 could improve the drug resistance of BC cells to 5-Fu. +other 35968900 hsa-mir-139 Instent Restenosis 5p-SP1 axis pairs were found in the miRNA-mRNA network, which could promote ISR development. +other 35968900 hsa-mir-24 Instent Restenosis 5p-SP1 axis pairs were found in the miRNA-mRNA network, which could promote ISR development. +genetics_overexpression_promote 35968506 hsa-mir-99a Atherosclerosis In vivo, the specific overexpression of miR-99a-5p significantly reduced atherosclerotic lesions, accompanied by a significant downregulation of autophagy marker CD68 protein expression. +exosome 35968497 hsa-mir-520f Aortic Aneurysm, Abdominal Therefore, BMSC exosome-derived SBF2-AS1 promotes AAA formation through the miRNA-520f-3p/SMARCD1 axis. +target gene 35968353 hsa-mir-133a Colorectal Neoplasms MIR133A regulates cell proliferation, migration, and apoptosis by targeting SOX9 in human colorectal cancer cells. +target gene 35968334 hsa-mir-1297 Osteosarcoma miR-1297 inhibits osteosarcoma cell proliferation and growth by targeting CCND2. +circulation_biomarker_prognosis_down 35968285 hsa-mir-4297 Glioma CONCLUSION: Our study uncovers sex-dependent characterization of serum miR-4297 in predicting glioma grade and the relapse risk for female patients, which underscores the clinical benefits of sex-specific analysis in non-coding RNA research. +lncRNA target 35967914 hsa-mir-23b Keloid CONCLUSION: These findings suggested that inhibition of miR-23b-3p/A20/RIPK1 axis induced apoptosis, limited proliferation and decreased extracellular matrix of KFs, providing a potential therapeutic target for treatment of keloid. +other 35967345 hsa-mir-144 Colitis The manipulation of miR-144/451 expression and DCs activation in IBD patients may be a novel therapeutic approach for the treatment of inflammatory diseases. +circulation_biomarker_diagnosis_ns 35967275 hsa-mir-137 Substance Withdrawal Syndrome Taken together, our data revealed circulating miR-137 as a potential blood-based marker that could reflect MA abstinence-dependent changes in striatal miR-137/SYNCRIP axis, and striatal SYNCRIP as a potential therapeutic target for striatum-associated cognitive dysfunction by MA withdrawal syndrome. +circulation_biomarker_diagnosis_ns 35967275 hsa-mir-137 Cognition Disorders Taken together, our data revealed circulating miR-137 as a potential blood-based marker that could reflect MA abstinence-dependent changes in striatal miR-137/SYNCRIP axis, and striatal SYNCRIP as a potential therapeutic target for striatum-associated cognitive dysfunction by MA withdrawal syndrome. +genetics_overexpression_promote 35966888 hsa-mir-133a Glioma The IGFBP3 overexpression effectively counteracts the glioma cell proliferation-inhibiting impact of miR-133a-5p. +other 35966515 hsa-mir-26b Primary Aldosteronism Unlike patients with NFA, miRNA-132, miRNA-143, miRNA-221, and miRNA-26b were less expressed in surrounding adrenal neoplasia AT compared to subcutaneous AT in patients with APA. +circulation_biomarker_prognosis_ns 35966511 hsa-mir-940 Adenocarcinoma of Lung 5p expression in LUAD and T stage (P=0.005), pathologic stage (P=0.047), race (White vs Asian & Black or African American) (P=0.041), residual tumor (P=0.043), and anatomic neoplasm subdivision2 (P=0.030). +other 35966402 hsa-mir-653 Uterine Cervical Neoplasms CONCLUSION: miR-3653, increased in CC, is related to HPV infection and may serve as a diagnostic and prognostic biomarker for CC patients. +other 35966325 hsa-mir-200 Ovarian Neoplasms DISCUSSION: The miR-200 family may be a marker for the diagnosis evaluation of ovarian cancer patients. +other 35966312 hsa-mir-1269a Esophageal Squamous Cell Carcinoma hsa-miR-1269a is significantly upregulated in ESCA patients with poor prognostic features. +lncRNA target 35966295 hsa-mir-494 Sepsis-Associated Encephalopathy The purpose of this study is to determine whether miRNA-494 can regulate the activation and oxidative stress of SAE microglia through SIRT3. +transcription factor target 35966249 hsa-mir-579 Adenocarcinoma of Lung CONCLUSION: Our study reveals that miR-579 acts as a tumor suppressor in LUAD and miR-579 can target and regulate the expression of CRABP2 to mediate cell proliferation and invasion. +circulation_biomarker_diagnosis_up 35966195 hsa-mir-154 Dementia, Vascular RESULTS: Exosomes isolated from serum of patients with VaD (n = 7) and age-matched control subjects (n = 7), and miRNA sequencing and bioinformatics analysis found that circulating exosome miRNA +transcription factor target 35965805 hsa-mir-194 Cardiomegaly CONCLUSIONS: In conclusion, increasing the expression of miR-194 can alleviate CH by targeting can and inhibiting the CnA/NFATc2 pathway. +other 35965798 hsa-mir-122 Polycystic Ovary Syndrome Among the patients with PCOS, miR5p was found to have more significant differences in the PCOS with insulin resistance group. +lncRNA target 35965793 hsa-mir-96 Carcinoma, Hepatocellular Finally, through multi-data crossover analysis and data analysis of HCC samples further confirmed the existence of the hsa_circ_0039466/miR +other 35965679 hsa-mir-1245 Squamous Cell Carcinoma of Head and Neck Intriguingly, we identified that miR-1245 simultaneously interacts with KRT80 and HNSCAT1, which bridges the regulatory function between KRT80 and HNSCAT1. +genetics_knock down_promote 35965521 hsa-mir-28 Cholangiocarcinoma knockdown in these functions (all P <0.05). +lncRNA target 35965517 hsa-mir-137 Glioblastoma Mechanistically, we identified that XIAP is a bona fide target of miR-137, which is essential for miR +lncRNA target 35965327 hsa-mir-223 Ovarian Neoplasms CONCLUSION: Circ-BNC2 suppresses the progression of OC via regulating miR +transcription factor target 35965273 hsa-mir-17 Polycystic Kidney Diseases Remarkably, Pkd2 is also inhibited via its 3'-UTR miR-17 motif, and Pkd2(17)-induced Polycystin-2 derepression retards cyst growth in Pkd1-mutant models. +circRNA target 35964907 hsa-mir-384 Carcinoma, Hepatocellular CONCLUSION: In this study, circ_0008285 could promote the malignant biological behaviors of HCC cells through miR-384/RRM2 axis and has the potential to become a therapeutic target for HCC, providing a new idea for targeted therapy of HCC. +transcription factor target 35964807 hsa-mir-378 Liver Failure, Acute CONCLUSION: Together, the present results indicate that miR-378 is a previously unrecognised post-ALF hepatocyte apoptosis regulator and may be a potential therapeutic target in the context of ALF. +tissue_expression_ns 35964709 hsa-mir-3074 Parasitic Diseases During ex vivo infection of canine and ovine placental explants, we evaluated the expression of 3 miRNAs (miR-30e-3p, miR +tissue_expression_ns 35964709 hsa-mir-127 Parasitic Diseases During ex vivo infection of canine and ovine placental explants, we evaluated the expression of 3 miRNAs (miR-30e-3p, miR +lncRNA target 35964231 hsa-mir-139 Pre-Eclampsia CONCLUSION: In summary, we confirmed that circ_0077109 inhibited trophoblast cell function through the regulation of miR5p/HOXD10 axis, which might be a potential target for PE treatment. +genetics_knock down_promote 35963709 hsa-mir-181c Carcinoma, Non-Small-Cell Lung Restoration of miR-181c-5p or knockdown of SNHG5 or CBX4 restrained NSCLC cell progression and inactivated the NF-kappaB pathway. +genetics_overexpression_promote 35963185 hsa-mir-210 Carcinoma, Endometrioid The level of RUNX1T1 in EC was downregulated after overexpressing miR +lncRNA target 35963157 hsa-mir-217 Inflammation CONCLUSIONS: Our findings for the first time highlighted that Sal alleviated pancreatic injury and inhibited inflammation by regulating miR +lncRNA target 35963157 hsa-mir-217 Pancreatitis CONCLUSIONS: Our findings for the first time highlighted that Sal alleviated pancreatic injury and inhibited inflammation by regulating miR +circulation_biomarker_diagnosis_up 35962993 hsa-mir-557 Hepatitis, Autoimmune In addition, serum EV-miR-557 levels >7.69 copies/mul were associated with a significantly higher risk of relapse in patients with AIH (7-year incidence rate: 11.1 vs. 35.4%, log-rank test, p < 0.05). +genetics_knock down_promote 35962723 hsa-mir-219a Osteoarthritis, Knee CONCLUSION: miR-219a-5p suppressed the pyroptosis in KOA by inactivating the NLRP3 signaling via targeting FBXO3, which might be a promising target for ameliorating KOA in the clinic. +other 35962561 hsa-mir-19b Lewy Body Disease 5p, miR-4505, and miR-451a) (false discovery rate P < 0.05). +other 35962561 hsa-let-7c Lewy Body Disease 5p, miR-4505, and miR-451a) (false discovery rate P < 0.05). +other 35962561 hsa-mir-29c Lewy Body Disease 5p, miR-4505, and miR-451a) (false discovery rate P < 0.05). +other 35962561 hsa-mir-29c REM Sleep Behavior Disorder 5p, miR-4505, and miR-451a) (false discovery rate P < 0.05). +other 35962561 hsa-mir-25 REM Sleep Behavior Disorder 5p, miR-4505, and miR-451a) (false discovery rate P < 0.05). +other 35962561 hsa-mir-140 Lewy Body Disease 5p, miR-4505, and miR-451a) (false discovery rate P < 0.05). +other 35962561 hsa-mir-140 REM Sleep Behavior Disorder 5p, miR-4505, and miR-451a) (false discovery rate P < 0.05). +other 35962561 hsa-mir-22 Lewy Body Disease 5p, miR-4505, and miR-451a) (false discovery rate P < 0.05). +other 35962561 hsa-mir-25 Lewy Body Disease 5p, miR-4505, and miR-451a) (false discovery rate P < 0.05). +other 35962561 hsa-mir-22 REM Sleep Behavior Disorder 5p, miR-4505, and miR-451a) (false discovery rate P < 0.05). +other 35962561 hsa-let-7c REM Sleep Behavior Disorder 5p, miR-4505, and miR-451a) (false discovery rate P < 0.05). +other 35962561 hsa-mir-19b REM Sleep Behavior Disorder 5p, miR-4505, and miR-451a) (false discovery rate P < 0.05). +lncRNA target 35962465 hsa-mir-218 Osteoarthritis 5p/NUMB axis. +circulation_biomarker_diagnosis_ns 35962012 hsa-mir-492 Carcinoma, Non-Small-Cell Lung qRT-PCR was used to measure expression levels of hsa_circ_0006423 and miR-492 in the plasma and tissue samples, and 3 NSCLC cell lines, respectively. +other 35961957 hsa-mir-596 Carcinoma, Non-Small-Cell Lung Furthermore, these finding elucidated that miR3p exerts a critical role in brain metastasis of NSCLC by modulating the YAP1-IL8 network, and this miRNA axis may provide a potential therapeutic strategy for brain metastasis. +lncRNA target 35961529 hsa-mir-15b Diabetic Neuropathies CONCLUSION: These results suggested that AGEs induced Abeta(1-42) deposition andcognitive decline through H19/miR-15b/ BACE1 axis in DE. +lncRNA target 35961529 hsa-mir-15b Cognition Disorders CONCLUSION: These results suggested that AGEs induced Abeta(1-42) deposition andcognitive decline through H19/miR-15b/ BACE1 axis in DE. +other 35961472 hsa-mir-223 Retinopathy of Prematurity mediated microglial polarization to the M2 phenotype. +other 35961236 hsa-mir-4668 Breast Neoplasms Our RP gene regulatory network indicates the transcription factors MYC, ETS1, and SPI1, and the miRNAs has-let-7c-5p, has-mir-20b-5p, and has-mir3p as regulators of the RPs expression in breast cancer. +other 35961236 hsa-mir-20b Breast Neoplasms Our RP gene regulatory network indicates the transcription factors MYC, ETS1, and SPI1, and the miRNAs has-let-7c-5p, has-mir-20b-5p, and has-mir3p as regulators of the RPs expression in breast cancer. +other 35961236 hsa-let-7c Breast Neoplasms Our RP gene regulatory network indicates the transcription factors MYC, ETS1, and SPI1, and the miRNAs has-let-7c-5p, has-mir-20b-5p, and has-mir3p as regulators of the RPs expression in breast cancer. +exosome 35960898 hsa-mir-92a Colorectal Neoplasms Herein, a ratiometric fluorescent biosensor based on self-assembled fluorescent gold nanoparticles (Au NPs) and duplex-specific nuclease (DSN)-assisted signal amplification was fabricated for sensitive detection of colorectal cancer (CRC)-associated exosomal miR-92a-3p. This biosensor exhibits excellent specificity and can distinguish CRC patients from healthy individuals by detecting miR-92a-3p extracted from clinical exosome samples, showing the potential in CRC diagnosis. +transcription factor target 35960478 hsa-mir-22 Acute Kidney Injury However, the mechanism of miR-22 on sepsis-induced AKI is not clearly understood. CONCLUSION: miR-22 can inhibit the inflammatory response, target the HMGB1, and inhibit the HMGB1/TLR4/NF-kB pathway, to attenuate the sepsis-induced AKI, which indicates that miR-22 may serve as a potential treatment target in sepsis-induced AKI. +other 35960478 hsa-mir-122 Sepsis RESULTS: In AKI rats, kidney injury was observed, accompanied by the down-regulated miR-122 expression and up-regulated HMBG1 expression. +transcription factor target 35960478 hsa-mir-22 Sepsis However, the mechanism of miR-22 on sepsis-induced AKI is not clearly understood. CONCLUSION: miR-22 can inhibit the inflammatory response, target the HMGB1, and inhibit the HMGB1/TLR4/NF-kB pathway, to attenuate the sepsis-induced AKI, which indicates that miR-22 may serve as a potential treatment target in sepsis-induced AKI. +other 35960478 hsa-mir-122 Acute Kidney Injury RESULTS: In AKI rats, kidney injury was observed, accompanied by the down-regulated miR-122 expression and up-regulated HMBG1 expression. +circRNA target 35960460 hsa-mir-383 Alzheimer Disease These findings indicated that circ_0003611 improved Abeta-triggered neuronal injury in AD through targeting the miR5p/KIF1B axis, which might deliver innovative therapy targeting for AD. +circRNA target 35960109 hsa-mir-15b Intervertebral Disc Degeneration Hsa_circ_0040039 may serve as a sponge of hsa-miR5p and hsa-miR-15b-5p, to regulate the expression of downstream genes (such as BRTC, SIAH1, and UBE2V1); thus, it may be involved in IDD-associated pathological processes via the Wnt/beta-catenin signaling pathway. +circRNA target 35960109 hsa-mir-424 Intervertebral Disc Degeneration Hsa_circ_0040039 may serve as a sponge of hsa-miR5p and hsa-miR-15b-5p, to regulate the expression of downstream genes (such as BRTC, SIAH1, and UBE2V1); thus, it may be involved in IDD-associated pathological processes via the Wnt/beta-catenin signaling pathway. +other 35960057 hsa-mir-140 Rotator Cuff Injuries Furthermore, in situ hybridization was performed to evaluate the presence of miR-140s in patients with massive tears and recurrent shoulder dislocation. +other 35960057 hsa-mir-140 Rotator Cuff Furthermore, in situ hybridization was performed to evaluate the presence of miR-140s in patients with massive tears and recurrent shoulder dislocation. +lncRNA target 35959879 hsa-mir-505 Primary Graft Dysfunction 5p alleviates acute rejection of liver transplantation by inducing M2 polarization of macrophages via the Myd88/TRAF6 axis, which suggests a potential strategy based on miRNAs in the follow-up treatment of liver transplantation. +transcription factor target 35959614 hsa-mir-34a Irritable Bowel Syndrome In colonic mucosal tissues from IBS patients, we detected upregulated miR-34a-5p and suppressed glucose metabolism enzymes expressions. CONCLUSION: Summarily, our study reports the roles and mechanisms of ATL-I in the oxidative stress-induced colonic mucosal epithelial cell dysfunction during IBS through regulating the miR-34a-5p-LDHA-glucose metabolism axis. +target gene 35959437 hsa-mir-8485 Ovarian Neoplasms Brucea javanica Oil Emulsion Promotes Autophagy in Ovarian Cancer Cells Through the miR-8485/LAMTOR3/mTOR/ATG13 Signaling Axis. +circulation_biomarker_diagnosis_up 35959150 hsa-mir-186 Diabetic Retinopathy 5p levels were upregulated in the blood samples of patients with ischemic stroke and OGD-induced SH-SY5Y cells. +circulation_biomarker_diagnosis_up 35959150 hsa-mir-186 Ischemic Stroke 5p levels were upregulated in the blood samples of patients with ischemic stroke and OGD-induced SH-SY5Y cells. +other 35959113 hsa-mir-508 Prostatic Neoplasms 3p were detected in PCa cell lines and tumor tissues, especially the more advanced T-stage. +other 35959113 hsa-mir-10a Prostatic Neoplasms 3p were detected in PCa cell lines and tumor tissues, especially the more advanced T-stage. +other 35959113 hsa-mir-20a Prostatic Neoplasms 3p were detected in PCa cell lines and tumor tissues, especially the more advanced T-stage. +lncRNA target 35958914 hsa-mir-133a Cardiovascular Diseases Thus, lncRNA-HCG18 inhibited cell viability of cardiac fibroblasts via the hsa-miR-133a/EGFR axis, which was regarded as a regulator of cell proliferation of cardiac fibroblasts in cardiovascular diseases. +genetics_overexpression_promote 35958896 hsa-mir-148a Carcinoma, Renal Cell In the cell reverse experiment, overexpression of WNT10a was confirmed to offset the miR-148a mimics effect on metastasis and proliferation of RCC cells. +lncRNA target 35958620 hsa-mir-365 Asthma stimuated inflammatory response by targeting ARRB2, which would shed new light to the understanding and therapeutics thereof of asthmatic inflammation. +lncRNA target 35958507 hsa-mir-136 Stomach Neoplasms Mechanistically, circ_0001013 bound to miR-136, which negatively targeted TWSG1 in the GC cells. +other 35958506 hsa-mir-34a Prostatic Neoplasms HSA-miR-34a-5p regulates the SIRT1/TP53 axis in prostate cancer. +lncRNA target 35958482 hsa-mir-762 Stomach Neoplasms It was also found that the effects of miR-762 on GC cells could be reversed by LZTS1, and miR-762 could upregulate the activation of the PI3K/AKT pathway but inhibit the Hippo pathway by targeting LZTS1. +lncRNA target 35958481 hsa-mir-34a Adenocarcinoma of Lung Whether MNX1-AS1 was involved in LAC by targeting miR-34a/SIRT1 axis was verified. These results showed that MNX1-AS1 contributes to LAC progression by targeting the miR-34a/SIRT1 axis. +circulation_biomarker_diagnosis_ns 35958461 hsa-mir-1 Urinary Bladder Neoplasms RESULTS: Six serum miRNAs (miR +circulation_biomarker_diagnosis_ns 35958461 hsa-mir-124 Urinary Bladder Neoplasms RESULTS: Six serum miRNAs (miR +circulation_biomarker_diagnosis_ns 35958461 hsa-mir-182 Urinary Bladder Neoplasms RESULTS: Six serum miRNAs (miR +circulation_biomarker_diagnosis_ns 35958461 hsa-mir-23b Urinary Bladder Neoplasms RESULTS: Six serum miRNAs (miR +circulation_biomarker_diagnosis_ns 35958461 hsa-mir-196a Urinary Bladder Neoplasms RESULTS: Six serum miRNAs (miR +circulation_biomarker_diagnosis_ns 35958461 hsa-mir-34a Urinary Bladder Neoplasms RESULTS: Six serum miRNAs (miR +lncRNA target 35958442 hsa-mir-222 Squamous Cell Carcinoma of Head and Neck CONCLUSION: MiR-222 was significantly upregulated in OSCC tissues and cells and regulated tumor progression by targeting CDKN1B. +circulation_biomarker_diagnosis_ns 35958438 hsa-mir-197 Venous Thrombosis MATERIALS AND METHODS: Venous blood samples were collected from DVT patients and healthy controls, and peripheral blood mononuclear cells (PBMCs) were isolated to examine the expression patterns of miR +genetics_GWAS 35958297 hsa-mir-21 Multiple Sclerosis This study aims to theoretically analyze the potential impact of single-nucleotide polymorphisms (SNPs) on mir-21 and mir-146a/b, which has been previously demonstrated as MS microRNA signature. This article presented a list of validated SNPs that could affect the expression or function of miR-21 and miR-146a/b for the future practical study of MS and active lesions. +genetics_GWAS 35958297 hsa-mir-146a Multiple Sclerosis This study aims to theoretically analyze the potential impact of single-nucleotide polymorphisms (SNPs) on mir-21 and mir-146a/b, which has been previously demonstrated as MS microRNA signature. This article presented a list of validated SNPs that could affect the expression or function of miR-21 and miR-146a/b for the future practical study of MS and active lesions. +other 35958213 hsa-mir-159a Plant Poisoning Furthermore, continuously higher expression of the miR159a.2 duplex in transgenic lines with the curly leaf phenotype indicates that miR159a.2 is functional in Arabidopsis and suggests that it is possible for a miRNA precursor to encode several regulatory small RNAs in plants. +other 35958213 hsa-mir-159 Plant Poisoning Furthermore, continuously higher expression of the miR159a.2 duplex in transgenic lines with the curly leaf phenotype indicates that miR159a.2 is functional in Arabidopsis and suggests that it is possible for a miRNA precursor to encode several regulatory small RNAs in plants. +genetics_overexpression_promote 35958013 hsa-mir-27a Hypoxia-Ischemia, Brain Interestingly, the overexpression of miR-27a reduced the infarcted volume and edema induced by HIE. +genetics_overexpression_promote 35958013 hsa-mir-27a Hypoxia-Ischemia, Brain, Newborn Interestingly, the overexpression of miR-27a reduced the infarcted volume and edema induced by HIE. +other 35957917 hsa-mir-520a Pancreatic Neoplasms MiR-520a-5p/PPP5C regulation pattern is identified as the key to gemcitabine resistance in pancreatic cancer. +lncRNA target 35957833 hsa-mir-370 Stomach Neoplasms Overall, our present study revealed that the LINC00659/miR-370/AQP3 axis contributes to GC progression, which may provide clues for the exploration of cancer biomarkers and therapeutic targets for GC. +lncRNA target 35957809 hsa-mir-26a Non-alcoholic Fatty Liver Disease CONCLUSION: Downregulation of GAS5 can activate the cAMP/CREB pathway through miR-26a-5p/PDE4B axis to mitigate hepatic lipid accumulation. +other 35957803 hsa-mir-4731 Urinary Bladder Neoplasms Furthermore, an investigation of the downstream and upstream factors of CCDC183-AS1 identified a novel MITF/CCDC183-AS1/miR5p/TCF7L2 axis in BC progression, which might furnish novel insights for developing effective diagnostic and therapeutic strategies for BC. +epigenetics 35957725 hsa-mir-7212 Acute Kidney Injury The mmu-miR5p-Hmox1 axis in ferroptosis and m6A RNA methylation regulators may have potential clinical significance for the future treatment of SA-AKI. +epigenetics 35957725 hsa-mir-7212 Sepsis The mmu-miR5p-Hmox1 axis in ferroptosis and m6A RNA methylation regulators may have potential clinical significance for the future treatment of SA-AKI. +other 35957689 hsa-mir-21 Prostatic Neoplasms A nomogram was constructed that contained four variables (ITGB8, hsa-miR-21, hsa-miR-30b and prostate-specific antigen (PSA) value) for predicting the risk of prostate cancer. The interaction network showed that hsa-miR-21, hsa-miR-30b, and ITGB8 may be utilized as new biomarkers for prostate cancer. +transcription factor target 35957539 hsa-mir-22 Liver Injury 5p as a therapeutic target for liver injury.Abbreviations: ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GSH: Glutathione, gamma-glutamyl cysteinel glycine; CCl(4): Carbon tetrachloride; HE: Haematoxylin and eosin; KEGG: Kyoto Encyclopedia of Genes and Genomes. +circulation_biomarker_diagnosis_up 35956043 hsa-mir-205 Esophageal Squamous Cell Carcinoma Based on the exosomal miRNAs identified in ESCC cell lines, our study demonstrated that plasma exosomal miR +circulation_biomarker_diagnosis_up 35956043 hsa-mir-375 Esophageal Squamous Cell Carcinoma Based on the exosomal miRNAs identified in ESCC cell lines, our study demonstrated that plasma exosomal miR +circulation_biomarker_diagnosis_up 35956043 hsa-mir-429 Esophageal Squamous Cell Carcinoma Based on the exosomal miRNAs identified in ESCC cell lines, our study demonstrated that plasma exosomal miR +other 35955622 hsa-mir-133a Aphasia, Primary Progressive In the svPPA cohort, we observed a generalized upregulation of miRNAs with miR-106b-5p and miR-133a-3p reaching statistical significance (miR-106b-5p: 2.69 /- 0.89 mean /- SD vs. +other 35955622 hsa-mir-106b Aphasia, Primary Progressive In the svPPA cohort, we observed a generalized upregulation of miRNAs with miR-106b-5p and miR-133a-3p reaching statistical significance (miR-106b-5p: 2.69 /- 0.89 mean /- SD vs. +lncRNA target 35955582 hsa-mir-143 Carcinoma, Renal Cell (4) Conclusions: ERK5 is regulated by miR-143, and ERK5 inhibition is a promising target for ccRCC treatment. +lncRNA target 35955552 hsa-let-7g Carcinoma, Hepatocellular In conclusion, our studies demonstrate positive feedback regulation for chronic TLR4 activation in the modulation of TLR4 expression level through the LIN28A/let-7g pathway in HCC and suggest a connection between chronic inflammation and TLR4 expression level in HCC for promoting tumorigenesis. +lncRNA target 35955552 hsa-let-7 Carcinoma, Hepatocellular In conclusion, our studies demonstrate positive feedback regulation for chronic TLR4 activation in the modulation of TLR4 expression level through the LIN28A/let-7g pathway in HCC and suggest a connection between chronic inflammation and TLR4 expression level in HCC for promoting tumorigenesis. +circulation_biomarker_diagnosis_ns 35955533 hsa-mir-625 Glioblastoma 5p was only identified in MVs isolated from GB patients before surgery and was not detected in plasma. +other 35955467 hsa-mir-34a Osteoarthritis RA and OA SF up-regulated miR-34a, -146a, -155, -181a, interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha, MMP-1, MMP-13, and ADAMTs-5 gene expression, while it down-regulated Col2a1. +other 35955467 hsa-mir-34a Arthritis, Rheumatoid RA and OA SF up-regulated miR-34a, -146a, -155, -181a, interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha, MMP-1, MMP-13, and ADAMTs-5 gene expression, while it down-regulated Col2a1. +other 35955412 hsa-mir-21 Genital Diseases, Female Overall, this research enhances our understanding of miR-21 function in granulosa cells and the mechanisms of BPA-induced reproductive impairment. +lncRNA target 35954468 hsa-mir-29c Breast Neoplasms Elevated miR-29c-5p Expression in Nipple Aspirate Fluid Is Associated with High mammographic density (MD) is associated with an increased risk of breast cancer, however the underlying mechanisms are largely unknown. Further validation and exploration of targets and downstream pathways of has-miR-29c-5p will provide better insight into the processes involved in the development of high MD and in the associated increased risk of breast cancer. +lncRNA target 35954468 hsa-mir-29c Muscular Dystrophies Further validation and exploration of targets and downstream pathways of has-miR-29c-5p will provide better insight into the processes involved in the development of high MD and in the associated increased risk of breast cancer. +circulation_biomarker_diagnosis_ns 35954369 hsa-mir-1246 Melanoma Evaluation of miR-1246 and miR3p baseline plasma levels might help clinicians to identify melanoma patients most likely to be unresponsive to targeted therapy or at higher risk for short-term PFS and mortality, thus improving their management. +circulation_biomarker_diagnosis_ns 35954369 hsa-mir-485 Melanoma Evaluation of miR-1246 and miR3p baseline plasma levels might help clinicians to identify melanoma patients most likely to be unresponsive to targeted therapy or at higher risk for short-term PFS and mortality, thus improving their management. +genetics_overexpression_promote 35954265 hsa-mir-187 Colorectal Neoplasms Overexpression of miR +transcription factor target 35954205 hsa-mir-192 Opitz GBBB Syndrome, X-Linked Among the DEmiRNAs, mi-192 was most induced by H(2)O(2)-mediated OS, and the downregulation of miR-192 alleviated PGC oxidative injury. +lncRNA target 35953862 hsa-mir-520c Osteosarcoma CONCLUSIONS: Nectin-4 as an oncogene can promote OS progression and metastasis by activating PI3K/AKT/NF-kappaB signaling via down-regulation of miR-520c-3p, which could represent a novel avenue for identifying a potential therapeutic target for improving patient outcomes. +circulation_biomarker_diagnosis_ns 35953459 hsa-mir-15 Myocardial Infarction, Acute We then used a rat AMI model to analyze myocardial infarction area by triphenyl tetrazolium chloride staining and assess serum cardiac troponin T level by ELISA and found that miR-15b-5p silencing reduced AMI injury in rats. +circulation_biomarker_diagnosis_ns 35953459 hsa-mir-15b Myocardial Infarction, Acute We then used a rat AMI model to analyze myocardial infarction area by triphenyl tetrazolium chloride staining and assess serum cardiac troponin T level by ELISA and found that miR-15b-5p silencing reduced AMI injury in rats. +genetics_overexpression_promote 35953439 hsa-mir-375 Squamous Cell Carcinoma of Head and Neck Overexpression of CST1 could reverse the anti-cancer effect of miR-375 overexpression in LSCC cells. +other 35953026 hsa-mir-126 Rhinitis, Allergic CONCLUSION: We propose that miR-126 may be involved in the pathogenesis of AR by positively regulating the expression of Treg cytokines and negatively regulating the expression of the Th1 and Th2 cytokines. +other 35953004 hsa-mir-3714 Encephalitis, Japanese Of these, the coding transcripts: Myosin Heavy Chain 10 (MYH10), Progestin and AdipoQ Receptor Family Member 8 (PAQR8), and the microRNAs: hsa-miR-193b-5p, hsa-miR-3714 and hsa-miR-513a-5p were found to be novel host factors deregulated during JEV infection. +other 35953004 hsa-mir-513a Encephalitis, Japanese Of these, the coding transcripts: Myosin Heavy Chain 10 (MYH10), Progestin and AdipoQ Receptor Family Member 8 (PAQR8), and the microRNAs: hsa-miR-193b-5p, hsa-miR-3714 and hsa-miR-513a-5p were found to be novel host factors deregulated during JEV infection. +other 35953004 hsa-mir-193b Encephalitis, Japanese Of these, the coding transcripts: Myosin Heavy Chain 10 (MYH10), Progestin and AdipoQ Receptor Family Member 8 (PAQR8), and the microRNAs: hsa-miR-193b-5p, hsa-miR-3714 and hsa-miR-513a-5p were found to be novel host factors deregulated during JEV infection. +genetics_knock down_promote 35952845 hsa-mir-140 Cerebral Hemorrhage CONCLUSION: circAFF1 knockdown can suppress neuronal ferroptosis in vivo to attenuate ICH injury, which was associated with its targeting with miR +genetics_knock down_promote 35952595 hsa-mir-96 Wounds and Injuries Gain- and loss-of-function studies were performed to examine the functions of the XIST/miR +other 35952470 hsa-mir-4261 Infertility CONCLUSIONS: PPOS protocol could up-regulate the expression of miR5p and down-regulate the expression of miR-4261 in granulosa cells of follicular fluid in infertile patients which involves a lot of cellular and molecular mechanisms requiring follow-up studies. +other 35952470 hsa-mir-6869 Infertility CONCLUSIONS: PPOS protocol could up-regulate the expression of miR5p and down-regulate the expression of miR-4261 in granulosa cells of follicular fluid in infertile patients which involves a lot of cellular and molecular mechanisms requiring follow-up studies. +transcription factor target 35952464 hsa-mir-7 Pituitary Diseases CONCLUSIONS: Cav-1/miR5p/SQSTM1 signaling pathway was the mechanism underlying low SS inhibiting endothelial mitophagy that involves mitochondrial homeostasis impairment and endothelial dysfunction. +lncRNA target 35951458 hsa-mir-561 Multiple Myeloma 5p/DLC1 axis inhibited the development of multiple myeloma by Long non-coding RNA NBR2 exerts a tumor-suppressive effect in a variety of cancers, but its role in multiple myeloma (MM) is unclear. +genetics_knock down_promote 35951366 hsa-mir-200b Breast Neoplasms Suppression of Dicer inhibited miR-200b expression, whereas miR-200b suppression recovered Dicer knockdown-induced migration, invasion, and cancer stem cells (CSCs) properties of the breast cancer cells. +other 35951089 hsa-mir-1296 Glioma Subsequently, a combination of a series of bioinformatics analyses, including correlation and survival analyses, identified miR5p as the most potent upstream miRNA of TMED3 in gliomas.Additionally, we analyzed the relationship between TMED3 level and tumor immune cell infiltration and immune checkpoint expression. +genetics_overexpression_promote 35951074 hsa-mir-187 Cataract RESULTS: The expression of miR-187 increased significantly in patients with cataracts, and the overexpression of miR-187 promoted the oxidative stress response in HLECs. +lncRNA target 35950642 hsa-mir-29b Skin Aging CONCLUSION: Our study presented a novel role for BMSCs-exo-miR-29b-3p in improving skin photoaging function, and these findings may provide new insights into the targeted treatment of skin photoaging. +other 35950475 hsa-mir-21 Postoperative Cognitive Complications The expression of miR-21, miR-132, and miR-200b in PSCI patients was higher than in PSCN patients. CONCLUSIONS: The miR-21 alone or combination of miR-21 and FA values are valuable diagnostic biomarkers in discriminating PSCI from PSCN. +transcription factor target 35950473 hsa-mir-129-1 Ischemic Stroke CONCLUSIONS: miR1-3p may be a relevant biomarker for the diagnosis of stroke caused by large artery atherosclerosis and could represent a novel therapeutic target for stroke treatment. +other 35950473 hsa-mir-5196 Ischemic Stroke 3p, was significantly different between the AIS and AS/HC groups. +other 35950473 hsa-mir-4312 Ischemic Stroke 3p, was significantly different between the AIS and AS/HC groups. +genetics_overexpression_promote 35950472 hsa-mir-211 Glioma Moreover, overexpression of RHBDD1 counteracted suppressive effects of miR +exosome 35950471 hsa-mir-152 Subarachnoid Hemorrhage CONCLUSIONS: Our study confirmed that the CSF-derived exosome miR +genetics_knock down_promote 35950211 hsa-mir-20 Non-Ischemic Diabetic Heart Disease Our study provides evidence that miR-320 is a late-responding miRNA that aggravates apoptosis and cardiac dysfunction in the diabetic heart, and that therapeutic knockdown of miR-320 is beneficial in partially restoring the deteriorated cardiac function. +other 35949612 hsa-mir-4668 Pancreatic Carcinoma Thus, the present analysis identified 11 miRNAs associated with pancreatic cancer and further identified miR5p as a potential biomarker for pancreatic cancer diagnosis. +circulation_biomarker_diagnosis_ns 35949317 hsa-mir-499a Pneumonia Combination of azithromycin and methylprednisolone alleviates Mycoplasma pneumoniae induced pneumonia by regulating miR-499a-5p/STAT3 axis. +other 35949047 hsa-mir-155 Burns 3p and their related signaling pathways. +other 35949047 hsa-mir-506 Burns 3p and their related signaling pathways. +genetics_knock down_promote 35949038 hsa-mir-873 Colorectal Neoplasms 5p could be sponged by hsa_circ_0045932, and its inhibitor also reversed the inhibitory effect of hsa_circ_0045932 knockdown on CRC cell progression. +lncRNA target 35948893 hsa-mir-26a Uterine Cervical Neoplasms CONCLUSIONS: MiR-26a-5p alleviated progression of CC by suppressing proliferation, migration and invasion, promoting apoptosis through downregulating HSDL2. +other 35948417 hsa-mir-181a Respiratory Distress Syndrome CONCLUSION: miR-181a-PTEN-pSTAT5-SOCS1 axis is a novel pathway responsible for immunomodulatory effect of MSC EVs in ARDS. +other 35947965 hsa-mir-141 Adenomyosis CONCLUSION: Circ_0061140 contributed to adenomyosis progression by binding to miR3p to induce LIN28B expression in vitro. +other 35947816 hsa-mir-192 Acquired Immunodeficiency Syndrome CONCLUSION: Decreased expression levels of miRNA-192 in patients with ocular manifestations and IRU, could facilitate identification of the status of the disease in HIV patients. +other 35947816 hsa-mir-543 Acquired Immunodeficiency Syndrome RESULTS: Hsa-miR5p and hsa-miR-543 levels were measured by qPCR using RNA isolated from PBMCs of HIVinfected patients. +transcription factor target 35947460 hsa-mir-514 Stomach Neoplasms Cdc42 guanine nucleotide exchange factor 9 (ARHGEF9), functioned as a tumor suppress factor in GC, was found as the downstream target of miR3p, and their expressions were negatively correlated in GC tumor tissues. +lncRNA target 35947460 hsa-mir-514b Stomach Neoplasms Our study reveals a novel lncRNA-p21/miR-514b-3p/ARHGEF9 pathway that can be targeted for GC therapy. +genetics_overexpression_promote 35947339 hsa-mir-100 Osteoporosis TMEM135 was downregulated in osteoporosis and upregulated in differentiated osteoblasts, as well as downregulated upon the overexpression of miR +lncRNA target 35947042 hsa-mir-199a Carcinoma, Squamous Cell, Skin CONCLUSIONS: Sulforaphane appears to inhibit sCC progression by impacting its growth and invasion ability, and regulates miR-199a-5p/Sirt1 and CD44ICD signaling pathways, and may be utilized to develop a curative approach for sSCC. +other 35946915 hsa-mir-7106 Dementia 5p). +lncRNA target 35946880 hsa-mir-222 Inflammatory Bowel Diseases 3p targets SOCS1 to aggravate the inflammatory response by suppressing VDR and activating STAT3 signaling in ulcerative colitis. +other 35946568 hsa-mir-1224 Carcinoma, Non-Small-Cell Lung 3p/HMGA2 axis. +circRNA target 35946546 hsa-mir-106b Uterine Cervical Neoplasms CircVPRBP and TRIM3 were decreased, and miR-106b-5p was increased in cervical cancer tissues and cell lines. CircVPRBP could inhibit the malignant biological behavior of cervical cancer cells by miR-106b-5p/TRIM3 axis, providing a promising therapeutic target for cervical cancer treatment. +target gene 35946541 hsa-mir-486 Adenocarcinoma of Lung Circ_0001058 represses the progression of lung adenocarcinoma through governing of the miR-486-5p/TEK signaling axis. +lncRNA target 35946537 hsa-mir-4284 Ovarian Neoplasms MiR-4284 targeted DMC1 which was downregulated in paclitaxel-resistant cells and reversed the inhibitory influence of miR-4284 silencing on the malignant characters of paclitaxel-resistant OC cells. +other 35946523 hsa-mir-651 Carcinoma, Hepatocellular 5p/TM4SF4 axis-mediated oncogenicity in HCC might shed new light on HCC diagnosis and therapy. +genetics_knock down_promote 35946509 hsa-mir-514a Wilms Tumor Changes in the proliferation, migration and apoptosis of WT cells after OSTM1-AS1, miR-514a-3p or MELK knockdown were assessed using the cell counting kit-8, Transwell and caspase-3 activity assays, respectively. +lncRNA target 35946473 hsa-mir-29a Diabetes Mellitus We showed microRNA-29a (miR-29a) modulates ADAM12 expression in the setting of diabetes and ischemia. Hence, elevated levels of miR-29a, as seen in diabetes and aging, likely contribute to vascular pathology, and modulation of miR-29a could be a therapeutic target. +other 35946384 hsa-mir-182 Hypoxia 5p/RGS5/RhoA axis regulated hypoxia-induced VSMCs phenotypic switch. +circulation_biomarker_diagnosis_ns 35944561 hsa-mir-142 Prostatic Neoplasms 3p has an ascendant one in prostate cancer serum samples and cells. +circRNA target 35943670 hsa-mir-600 Colorectal Neoplasms Circ_0001821 regulated the developmental process of CRC through miR-600/ISOC1 axis. +other 35943151 hsa-let-7c Pancreatic Carcinoma We aimed to show that microRNAs let-7c and 7d can be used as independent predictive biomarkers for metastatic pancreatic cancer. +other 35943151 hsa-let-7d Pancreatic Carcinoma We aimed to show that microRNAs let-7c and 7d can be used as independent predictive biomarkers for metastatic pancreatic cancer. +other 35943150 hsa-mir-206 Carcinoma, Hepatocellular RESULTS: The levels of miR-206 and miR-222 were significantly higher (P < .05) and the level of miR-126 was lower (P < .05) in patients with hepatocellular carcinoma than in healthy subjects. +other 35943150 hsa-mir-222 Carcinoma, Hepatocellular RESULTS: The levels of miR-206 and miR-222 were significantly higher (P < .05) and the level of miR-126 was lower (P < .05) in patients with hepatocellular carcinoma than in healthy subjects. +other 35943150 hsa-mir-126 Carcinoma, Hepatocellular RESULTS: The levels of miR-206 and miR-222 were significantly higher (P < .05) and the level of miR-126 was lower (P < .05) in patients with hepatocellular carcinoma than in healthy subjects. +target gene 35943044 hsa-mir-130a Lung Neoplasms Luteolin suppresses lung cancer progression through targeting the circ_0000190/miR-130a-3p/notch-1 signaling pathway. +transcription factor target 35942686 hsa-mir-424 Vesico-Ureteral Reflux Furthermore, we demonstrated that miR-34a, miR-424, and miR-516, upregulated in VU, cooperatively suppressed keratinocyte migration and growth while promoting inflammatory response. +transcription factor target 35942686 hsa-mir-516 Vesico-Ureteral Reflux Furthermore, we demonstrated that miR-34a, miR-424, and miR-516, upregulated in VU, cooperatively suppressed keratinocyte migration and growth while promoting inflammatory response. +transcription factor target 35942686 hsa-mir-34a Vesico-Ureteral Reflux Furthermore, we demonstrated that miR-34a, miR-424, and miR-516, upregulated in VU, cooperatively suppressed keratinocyte migration and growth while promoting inflammatory response. +other 35942551 hsa-mir-633 Colorectal Neoplasms KAI1 and miR-633 expression levels were significantly correlated with the prognosis of patients with melanoma combined with CRC. +other 35942551 hsa-mir-633 Melanoma KAI1 and miR-633 expression levels were significantly correlated with the prognosis of patients with melanoma combined with CRC. +other 35942384 hsa-mir-1246 Chronic Periodontitis CONCLUSION: Abnormally elevated levels of miR-1246 in saliva of patients with chronic periodontitis correlate with levels of periodontal indices, inflammatory cytokines, and protease molecules. +target gene 35942374 hsa-mir-125a Prostatic Neoplasms Curcumol Inhibits the Development of Prostate Cancer by miR-125a/STAT3 Axis. +genetics_overexpression_promote 35942174 hsa-mir-147a Glioblastoma In addition, cells with or without the miR-147a mimic treatment were also incubated with temozolomide (TMZ) to investigate whether miR-147a overexpression could sensitize human glioblastoma cells to TMZ chemotherapy in vitro. +genetics_overexpression_promote 35942174 hsa-mir-147a Thyroid Cancer, Papillary In addition, cells with or without the miR-147a mimic treatment were also incubated with temozolomide (TMZ) to investigate whether miR-147a overexpression could sensitize human glioblastoma cells to TMZ chemotherapy in vitro. +other 35941891 hsa-mir-21 Gastritis, Atrophic CONCLUSIONS: MiR-21 was over-expressed in patients with gastric precancerous conditions irrespective of etiology, while in the same subgroups miR-142 and miR-223 were under-expressed compared to healthy controls. +other 35941891 hsa-mir-155 Gastritis, Atrophic We aimed to analyze the expression profile of selected miRNAs (miR21, miR142, miR223, miR155) in patients with autoimmune atrophic gastritis (AAG), patients with non-autoimmune multifocal atrophic gastritis (MAG), and healthy control subjects (HC). +other 35941891 hsa-mir-223 Gastritis, Atrophic CONCLUSIONS: MiR-21 was over-expressed in patients with gastric precancerous conditions irrespective of etiology, while in the same subgroups miR-142 and miR-223 were under-expressed compared to healthy controls. +other 35941891 hsa-mir-142 Gastritis, Atrophic CONCLUSIONS: MiR-21 was over-expressed in patients with gastric precancerous conditions irrespective of etiology, while in the same subgroups miR-142 and miR-223 were under-expressed compared to healthy controls. +target gene 35941331 hsa-mir-23b Osteosarcoma miRNA-23b-5p affects the proliferation, migration and invasion of osteosarcoma by targeting TMEM127. +exosome 35941326 hsa-mir-551b Breast Neoplasms Collectively, these findings indicated that BMSC-derived exosomal miR-551b-3p could suppress the development of breast cancer via downregulating TRIM31. +transcription factor target 35941302 hsa-mir-152 Reperfusion Injury, Renal Ischemia Inhibition of miR +other 35941185 hsa-mir-502 Alzheimer Disease 5p were identified as potential synaptosomal miRNAs upregulated with disease progression based on AD Braak stages. +other 35941185 hsa-mir-877 Alzheimer Disease 5p were identified as potential synaptosomal miRNAs upregulated with disease progression based on AD Braak stages. +other 35941185 hsa-mir-501 Alzheimer Disease 5p were identified as potential synaptosomal miRNAs upregulated with disease progression based on AD Braak stages. +transcription factor target 35940944 hsa-mir-1294 Breast Neoplasms In conclusion, MiRNA1294 acted as a tumor suppressor in BC, which might serve as a potential target for the development of anti-neoplastic therapies in BC. +transcription factor target 35940515 hsa-mir-155 Metabolic Associated Fatty Liver Disease Collectively, altering high-fat dietary habits could protect against MAFLD motivated by air pollution, and miR-155 might be an effective preventive and therapeutic target for this process. +genetics_overexpression_promote 35940217 hsa-mir-122a Reperfusion Injury, Intestinal Ischemia Furthermore, in IEC-6 cells, a miR-122a inhibitor and an EGFR-overexpression plasmid significantly reduced pyroptosis and alleviated intestinal I/R injury via activating the EGFR-NLRP3 signaling pathway, showing that miR-122a is very essential for regulating intestinal I/R injury. +exosome 35940082 hsa-mir-195 Pre-Eclampsia MicroRNA-195 (miR-195) was decreased in the patients with pre-eclampsia (PE), which was implicated to modulate PE. Exosomal miR-195 in hUC-MSCs alleviated hypoxia-induced cell damage through TFPI2, which might provide a potential therapeutic approach for pre-eclampsia. +lncRNA target 35940082 hsa-mir-195 Pneumonia, Mycoplasma Moreover, tissue factor pathway inhibitor 2 (TFPI2), which was highly expressed in the placenta of PE patients, was negatively correlated with miR-195 levels. +genetics_overexpression_promote 35939970 hsa-mir-188 Prostatic Neoplasms 3p) is a direct target of hsa_circ_0102485, and cotransfection of hsa_circ_0102485 in PCa cells overexpressing miR +circRNA target 35939870 hsa-mir-144 Pulmonary Disease, Chronic Obstructive Thus, our results conclude that the circRERE/miR3p/TLR2/MMP9 axis in COPD pulmonary monocytes is critical for CS-induced COPD and circRERE may serve as a potential target for COPD. +circRNA target 35939870 hsa-mir-144 Hamartoma Syndrome, Multiple Thus, our results conclude that the circRERE/miR3p/TLR2/MMP9 axis in COPD pulmonary monocytes is critical for CS-induced COPD and circRERE may serve as a potential target for COPD. +epigenetics 35939560 hsa-mir-124a Neoplasms, Second Primary RESULTS: The methylation level of miR-124a-3 in the HP group and non-MGC group and that of EMX1 in the HP group significantly decreased in the long term after eradication. +epigenetics 35939560 hsa-mir-124a Stomach Neoplasms RESULTS: The methylation level of miR-124a-3 in the HP group and non-MGC group and that of EMX1 in the HP group significantly decreased in the long term after eradication. +epigenetics 35939560 hsa-mir-124a Gastric Cancer, Metachronous RESULTS: The methylation level of miR-124a-3 in the HP group and non-MGC group and that of EMX1 in the HP group significantly decreased in the long term after eradication. +circulation_biomarker_diagnosis_up 35939376 hsa-mir-19b Shock, Hemorrhagic METHODS: Blood samples from HS patients (blood pressure <90 mm Hg and >/=2 U blood) were collected upon admission, completion of hemostasis, and after 24 hours for miR-19b (quantitative reverse transcription PCR) and syndecan-1 (enzyme-linked immunosorbent assay) and compared with controls and minimally injured (Injury Severity Score, 1.8, p < 0.05). +other 35887024 hsa-mir-1247 Cushing Syndrome QPCR revealed the upregulated expression of miR5p in CPA and PBMAH (log2 fold change > 2.5, p < 0.05). +transcription factor target 35887021 hsa-mir-34c Colorectal Neoplasms We also found that, in colorectal and triple-negative breast cancer cells, AdoMet inhibited the expression of Notch gene, which, by luciferase assay, resulted the direct target of miRNAs-34a/-34c/-449a. +transcription factor target 35887021 hsa-mir-34a Colorectal Neoplasms We also found that, in colorectal and triple-negative breast cancer cells, AdoMet inhibited the expression of Notch gene, which, by luciferase assay, resulted the direct target of miRNAs-34a/-34c/-449a. +other 35886938 hsa-mir-125a Deltaretrovirus Infections 5p) in both HTLV-2 infected PBMC and BJABGu cell lines. +other 35886938 hsa-mir-125a HTLV-II Infections 5p) in both HTLV-2 infected PBMC and BJABGu cell lines. +other 35886938 hsa-mir-548d HTLV-II Infections 5p) in both HTLV-2 infected PBMC and BJABGu cell lines. +other 35886938 hsa-mir-381 Deltaretrovirus Infections 5p) in both HTLV-2 infected PBMC and BJABGu cell lines. +other 35886938 hsa-mir-548d Deltaretrovirus Infections 5p) in both HTLV-2 infected PBMC and BJABGu cell lines. +other 35886938 hsa-mir-502 Deltaretrovirus Infections 5p) in both HTLV-2 infected PBMC and BJABGu cell lines. +other 35886938 hsa-mir-502 HTLV-II Infections 5p) in both HTLV-2 infected PBMC and BJABGu cell lines. +other 35886938 hsa-mir-381 HTLV-II Infections 5p) in both HTLV-2 infected PBMC and BJABGu cell lines. +other 35886863 hsa-mir-133a Muscular Dystrophy, Duchenne Our data suggest that Smad8 is a negative regulator of miR-1, miR-133a, and miR-133b in muscle cells and that the BMP4-Smad8 axis is a driver of dystrophic pathology in DMD. +other 35886863 hsa-mir-133b Muscular Dystrophy, Duchenne Our data suggest that Smad8 is a negative regulator of miR-1, miR-133a, and miR-133b in muscle cells and that the BMP4-Smad8 axis is a driver of dystrophic pathology in DMD. +other 35886863 hsa-mir-1 Muscular Dystrophy, Duchenne Our data suggest that Smad8 is a negative regulator of miR-1, miR-133a, and miR-133b in muscle cells and that the BMP4-Smad8 axis is a driver of dystrophic pathology in DMD. +circulation_biomarker_diagnosis_ns 35886860 hsa-mir-1 Heart Failure In diabetic HFpEF rats, we examined a selected panel of 12 circulating miRNAs associated with HF (miR +circulation_biomarker_diagnosis_ns 35886860 hsa-mir-126a Heart Failure In diabetic HFpEF rats, we examined a selected panel of 12 circulating miRNAs associated with HF (miR +circulation_biomarker_diagnosis_ns 35886860 hsa-mir-378 Heart Failure In diabetic HFpEF rats, we examined a selected panel of 12 circulating miRNAs associated with HF (miR +circulation_biomarker_diagnosis_ns 35886860 hsa-mir-21 Heart Failure In diabetic HFpEF rats, we examined a selected panel of 12 circulating miRNAs associated with HF (miR +circulation_biomarker_diagnosis_ns 35886860 hsa-mir-195 Heart Failure In diabetic HFpEF rats, we examined a selected panel of 12 circulating miRNAs associated with HF (miR +circulation_biomarker_diagnosis_ns 35886860 hsa-mir-206 Heart Failure In diabetic HFpEF rats, we examined a selected panel of 12 circulating miRNAs associated with HF (miR +circulation_biomarker_diagnosis_ns 35886860 hsa-mir-34a Heart Failure In diabetic HFpEF rats, we examined a selected panel of 12 circulating miRNAs associated with HF (miR +lncRNA target 35885930 hsa-mir-155 COVID-19 We speculated that microRNA-155 facilitates immune inflammation via targeting SOCS1, thus establishing its association with disease prognosis. +lncRNA target 35885665 hsa-mir-155 Fibrosis The link between reactive oxygen species (ROS), tumour suppressor p53 (p53), and liver fibrosis-during the pathogenesis of TAA-induced liver injury-associated with miR-155 dysregulation with and without RES incorporation has not been previously studied. +transcription factor target 35885665 hsa-mir-155 Chemical and Drug Induced Liver Injury The link between reactive oxygen species (ROS), tumour suppressor p53 (p53), and liver fibrosis-during the pathogenesis of TAA-induced liver injury-associated with miR-155 dysregulation with and without RES incorporation has not been previously studied. Liver injuries developed in the model group were confirmed by a significant (p < 0.0001) elevation of hepatic tissue levels of miR-155, ROS, p53, and the profibrogenic biomarkers: tissue inhibitor of metalloproteinases-1 and alpha-smooth muscle actin, as well as collagen deposition (fibrosis). +other 35885665 hsa-mir-155 Liver Diseases MicroRNAs (miRs), such as miR-155, have been implied in the pathogenesis of liver disease, and regulated by the antioxidant and anti-inflammatory compound resveratrol (RES). +lncRNA target 35885439 hsa-mir-181a Pre-Eclampsia Through the performance of the training cohort (0.848 AUC, 0.73-0.96 95% CI, 80% sensitivity, 85% specificity, p < 0.001) and the validation cohort (0.852 AUC, 0.74-0.98 95% CI, 75% sensitivity, 87% specificity, p < 0.001) from one hundred and fifty-two women with a combination of miR-210, miR-181a and BMI, we established a preeclampsia prediction model for the first trimester. +lncRNA target 35885439 hsa-mir-210 Pre-Eclampsia Through the performance of the training cohort (0.848 AUC, 0.73-0.96 95% CI, 80% sensitivity, 85% specificity, p < 0.001) and the validation cohort (0.852 AUC, 0.74-0.98 95% CI, 75% sensitivity, 87% specificity, p < 0.001) from one hundred and fifty-two women with a combination of miR-210, miR-181a and BMI, we established a preeclampsia prediction model for the first trimester. +transcription factor target 35884996 hsa-mir-506 Pancreatic Carcinoma In PDAC, miR-506 is mainly considered as a tumor-suppressing miRNA. +transcription factor target 35884935 hsa-mir-375 Spinal Cord Injuries Expression analysis of various miRNAs, however, revealed changes after SCI and ESWT, with increased miR-375, indicating a neuroprotective effect, and decreased miR5p potentially improving neuroplasticity via its regulatory involvement with BDNF. +transcription factor target 35884935 hsa-mir-382 Spinal Cord Injuries Expression analysis of various miRNAs, however, revealed changes after SCI and ESWT, with increased miR-375, indicating a neuroprotective effect, and decreased miR5p potentially improving neuroplasticity via its regulatory involvement with BDNF. +other 35884866 hsa-mir-107 Depression Additionally, miRNA analysis identified hsa-miR-107 as a possible biological link between APOE epsilon4, depressive symptoms, and cognitive impairment. +genetics_knock down_suppress 35884864 hsa-mir-138 Spinal Cord Injuries 5p downregulation correlates with the overexpression of its pro-apoptotic targets. +other 35884636 hsa-let-7c Tic Disorders As a result, 10 miRNAs (hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-let-7f, hsa-miR3p, hsa-miR-29a-3p, hsa-miR-30b-5p, hsa-miR-125b-5p, and hsa-miR-1469) have demonstrated a significantly different expression signature in the TDs group compared to HCs with excellent area under curve (AUC) values of 0.99, 0.973, 0.997, 1, 0.99, 0.997, 0.987, 0.993, 0.977, and 0.997, respectively, and the diagnostic efficacy of miRNAs was also estimated for discriminating TTD from CTD or TS. +other 35884636 hsa-mir-125b Tic Disorders As a result, 10 miRNAs (hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-let-7f, hsa-miR3p, hsa-miR-29a-3p, hsa-miR-30b-5p, hsa-miR-125b-5p, and hsa-miR-1469) have demonstrated a significantly different expression signature in the TDs group compared to HCs with excellent area under curve (AUC) values of 0.99, 0.973, 0.997, 1, 0.99, 0.997, 0.987, 0.993, 0.977, and 0.997, respectively, and the diagnostic efficacy of miRNAs was also estimated for discriminating TTD from CTD or TS. +other 35884636 hsa-mir-25 Tic Disorders As a result, 10 miRNAs (hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-let-7f, hsa-miR3p, hsa-miR-29a-3p, hsa-miR-30b-5p, hsa-miR-125b-5p, and hsa-miR-1469) have demonstrated a significantly different expression signature in the TDs group compared to HCs with excellent area under curve (AUC) values of 0.99, 0.973, 0.997, 1, 0.99, 0.997, 0.987, 0.993, 0.977, and 0.997, respectively, and the diagnostic efficacy of miRNAs was also estimated for discriminating TTD from CTD or TS. +other 35884636 hsa-mir-1469 Tic Disorders As a result, 10 miRNAs (hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-let-7f, hsa-miR3p, hsa-miR-29a-3p, hsa-miR-30b-5p, hsa-miR-125b-5p, and hsa-miR-1469) have demonstrated a significantly different expression signature in the TDs group compared to HCs with excellent area under curve (AUC) values of 0.99, 0.973, 0.997, 1, 0.99, 0.997, 0.987, 0.993, 0.977, and 0.997, respectively, and the diagnostic efficacy of miRNAs was also estimated for discriminating TTD from CTD or TS. +other 35884636 hsa-mir-29a Tic Disorders As a result, 10 miRNAs (hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-let-7f, hsa-miR3p, hsa-miR-29a-3p, hsa-miR-30b-5p, hsa-miR-125b-5p, and hsa-miR-1469) have demonstrated a significantly different expression signature in the TDs group compared to HCs with excellent area under curve (AUC) values of 0.99, 0.973, 0.997, 1, 0.99, 0.997, 0.987, 0.993, 0.977, and 0.997, respectively, and the diagnostic efficacy of miRNAs was also estimated for discriminating TTD from CTD or TS. +other 35884636 hsa-let-7f Tic Disorders As a result, 10 miRNAs (hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-let-7f, hsa-miR3p, hsa-miR-29a-3p, hsa-miR-30b-5p, hsa-miR-125b-5p, and hsa-miR-1469) have demonstrated a significantly different expression signature in the TDs group compared to HCs with excellent area under curve (AUC) values of 0.99, 0.973, 0.997, 1, 0.99, 0.997, 0.987, 0.993, 0.977, and 0.997, respectively, and the diagnostic efficacy of miRNAs was also estimated for discriminating TTD from CTD or TS. +other 35884636 hsa-let-7b Tic Disorders As a result, 10 miRNAs (hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-let-7f, hsa-miR3p, hsa-miR-29a-3p, hsa-miR-30b-5p, hsa-miR-125b-5p, and hsa-miR-1469) have demonstrated a significantly different expression signature in the TDs group compared to HCs with excellent area under curve (AUC) values of 0.99, 0.973, 0.997, 1, 0.99, 0.997, 0.987, 0.993, 0.977, and 0.997, respectively, and the diagnostic efficacy of miRNAs was also estimated for discriminating TTD from CTD or TS. +other 35884636 hsa-let-7e Tic Disorders As a result, 10 miRNAs (hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-let-7f, hsa-miR3p, hsa-miR-29a-3p, hsa-miR-30b-5p, hsa-miR-125b-5p, and hsa-miR-1469) have demonstrated a significantly different expression signature in the TDs group compared to HCs with excellent area under curve (AUC) values of 0.99, 0.973, 0.997, 1, 0.99, 0.997, 0.987, 0.993, 0.977, and 0.997, respectively, and the diagnostic efficacy of miRNAs was also estimated for discriminating TTD from CTD or TS. +other 35884636 hsa-let-7a Tic Disorders As a result, 10 miRNAs (hsa-let-7a, hsa-let-7b, hsa-let-7c, hsa-let-7e, hsa-let-7f, hsa-miR3p, hsa-miR-29a-3p, hsa-miR-30b-5p, hsa-miR-125b-5p, and hsa-miR-1469) have demonstrated a significantly different expression signature in the TDs group compared to HCs with excellent area under curve (AUC) values of 0.99, 0.973, 0.997, 1, 0.99, 0.997, 0.987, 0.993, 0.977, and 0.997, respectively, and the diagnostic efficacy of miRNAs was also estimated for discriminating TTD from CTD or TS. +lncRNA target 35884604 hsa-mir-200c Triple Negative Breast Neoplasms We demonstrated that NPC1 is directly targeted by microRNA-200c (miR-200c), a potent suppressor of EMT, providing a mechanism for its differential expression in breast cancer subtypes. +genetics_knock down_promote 35884594 hsa-mir-99a Stomach Neoplasms After knockdown of HOXC-AS1, miR-99a-3p was clearly overexpressed in GC cells. Finally, rescue experiments for CCK-8 were completed, disclosing that HOXC-AS1 promoted cell progression of GC through sponging miR-99a-3p followed by subsequent upregulation of MMP8. +circulation_biomarker_diagnosis_ns 35884554 hsa-mir-222 Triple Negative Breast Neoplasms This study aimed to evaluate the modulation of the expression of three miRNAs, miR-21, miR-222 and miR3p, in the serum exosomes of patients with high-grade gliomas (HGGs) and brain metastases (BMs) to verify their usefulness in the differential diagnosis of brain masses; then, it focused on their variations following the surgical and/or radiosurgical treatment of the BMs. +circulation_biomarker_diagnosis_ns 35884554 hsa-mir-124 Triple Negative Breast Neoplasms This study aimed to evaluate the modulation of the expression of three miRNAs, miR-21, miR-222 and miR3p, in the serum exosomes of patients with high-grade gliomas (HGGs) and brain metastases (BMs) to verify their usefulness in the differential diagnosis of brain masses; then, it focused on their variations following the surgical and/or radiosurgical treatment of the BMs. +circulation_biomarker_diagnosis_ns 35884554 hsa-mir-21 Triple Negative Breast Neoplasms This study aimed to evaluate the modulation of the expression of three miRNAs, miR-21, miR-222 and miR3p, in the serum exosomes of patients with high-grade gliomas (HGGs) and brain metastases (BMs) to verify their usefulness in the differential diagnosis of brain masses; then, it focused on their variations following the surgical and/or radiosurgical treatment of the BMs. +other 35884524 hsa-mir-1 Pulmonary Fibrosis Using an in vitro co-culture system, involving directly irradiated skeletal muscle and unirradiated ventricular cardiac human cells, we propose the role of miR-1/133a as mediators of the abscopal response, suggesting that miRNA-based strategies could be relevant for limiting tissue-dependent reactions in non-directly irradiated tissues. +exosome 35884336 hsa-mir-92a Colorectal Neoplasms Colorectal cancer (CRC)-associated miR-92a-3p extracted from exosomes was selected as the target. +lncRNA target 35883863 hsa-mir-155 Hypertension 5p/eNOS/NO/IkappaB cycle after the activation of AMPK/UCP2 and the subsequent inhibition of ROS in hypertensive rat renal artery endothelial cells. +lncRNA target 35883863 hsa-mir-155 Vascular Diseases 5p/eNOS/NO/IkappaB cycle after the activation of AMPK/UCP2 and the subsequent inhibition of ROS in hypertensive rat renal artery endothelial cells. +exosome 35883438 hsa-mir-21 Ischemic Stroke These results suggest that BMSC-Exos could promote angiogenesis via miR +transcription factor target 35883205 hsa-mir-148a Liver Cirrhosis 5p and inhibiting the Notch signaling pathway. +exosome 35883161 hsa-mir-126 Ovarian Failure, Premature 3p promote angiogenesis and attenuate OGCs apoptosis in POF, which highlighted the potential of exosomes containing miR +transcription factor target 35883156 hsa-mir-152 Osteoporosis 5p is the first identified to regulate osteogenic differentiation by directly targeting autophagy-related protein ATG14 and regulating oxidative stress and therapeutic inhibition of miR +genetics_overexpression_promote 35883151 hsa-mir-17 Aortic Aneurysm, Abdominal Furthermore, overexpression of miR +circulation_biomarker_diagnosis_ns 35882857 hsa-mir-670 Kidney Failure, Chronic Elevated levels of plasma exosomal miR +circRNA target 35882184 hsa-mir-182 Rhinitis, Allergic Furthermore, hsa_circRNA_404013 may regulate the expression level of BDNF through hsa-mir +genetics_overexpression_suppress 35882167 hsa-mir-498 Stomach Neoplasms The stimulation of GC cell proliferation, migration, and EMT, which had been engendered by CEACAM5 overexpression, was reversible through the overexpression of miR-498. +other 35881155 hsa-mir-107 Alzheimer Disease Circ_0049472 modulated KIF1B by serving as a miR-107 decoy, thereby mediating Abeta-induced neurotoxicity, suggesting that circ_0049472 may be involved in AD pathogenesis. +other 35881147 hsa-mir-222 Alcoholism miR3p has been reported to play a key role in various neurological diseases and is strongly associated with alcohol dependence. +other 35881147 hsa-mir-222 Nervous System Diseases miR3p has been reported to play a key role in various neurological diseases and is strongly associated with alcohol dependence. +genetics_GWAS 35881147 hsa-mir-222 Cataract, posterior polar, 3 Following adeno-associated virus (AAV)-mediated overexpression or knockdown of miR +other 35880950 hsa-mir-421 Reperfusion Injury, Cerebral Ischemia Collectively, the regulation of lncRNA ZFAS1/miR3p/MEF2C axis showed protective effects on cerebral ischemia-reperfusion injury. +other 35880624 hsa-mir-185 Norrie disease Taken together, our data suggested that circ_0114428 might promote DN progression by regulating the miR5p/SMAD3 axis. +other 35880619 hsa-mir-223 Pneumonia, Mycoplasma CONCLUSIONS: All results manifested that circ_0005714 retarded the progression of PE by mediating the miR3p/ADAM9 signal network. +lncRNA target 35880572 hsa-mir-217 Pulmonary Disease, Chronic Obstructive Collectively, these results suggest that GAS5 can suppress airway inflammation and fibroblast activation by regulating miR5p/PTEN axis, which may help develop novel therapeutic strategies against COPD. +lncRNA target 35880572 hsa-mir-217 Pneumonia Collectively, these results suggest that GAS5 can suppress airway inflammation and fibroblast activation by regulating miR5p/PTEN axis, which may help develop novel therapeutic strategies against COPD. +circulation_biomarker_prognosis_up 35880500 hsa-mir-133b Muscular Dystrophy, Duchenne We found a significant upregulation of serum miR-1, miR-133a, miR-133b and miR-206 in our cohort of BMD patients, supporting the role of these miRNAs in the pathophysiology of the disease, and we identified serum cut-off levels discriminating patients from healthy controls, confiming the potential of circulating miRNAs as promising noninvasive biomarkers. Moreover, serum levels of miR-133b were found to be associated with fibrosis at muscle biopsy and with patients' motor performances, suggesting that miR-133b might be a useful prognostic marker for BMD patients. +circulation_biomarker_diagnosis_ns 35880306 hsa-mir-647 Atherosclerosis Moreover, the expression of miR-647 increased in ox-LDL-treated vascular smooth muscle cells and peripheral blood of patients with coronary heart disease. +other 35880174 hsa-mir-548k Pre-Eclampsia Based on the transcriptome level of key genes, we proposed that RELA-miR-548K/miRTPBG may be a potential RNA regulatory pathway regulating the progression of early preeclampsia. +other 35880174 hsa-mir-1206 Pre-Eclampsia Based on the transcriptome level of key genes, we proposed that RELA-miR-548K/miRTPBG may be a potential RNA regulatory pathway regulating the progression of early preeclampsia. +circulation_biomarker_prognosis_ns 35880009 hsa-mir-487b Vitiligo ROC curve analysis (area under curve = 0.840) indicated that hsa-miR-487b-3p could serve as a biomarker for the prognosis of vitiligo progression. CONCLUSION: Serum exosomal hsa-miR-487b-3p can be a biomarker to detect vitiligo progression. +circulation_biomarker_diagnosis_ns 35879917 hsa-mir-34a Reperfusion Injury, Hepatic Ischemia We constructed a rat HIRI model and treated it with an intraperitoneal injection of agomir-miR-34a-5p or agomir-normal control (NC) for 7 days after the surgery. HIRI+agomir-miR-34a-5p rats exhibited significantly higher miR-34a-5p expression, lower serum alanine aminotransferase, aspartate aminotransferase, alleviated hepatic necrosis, reduced hepa- tocyte apoptosis, and decreased expression of apoptosis-related proteins, when compared with HIRI+agomir-NC rats (P < .05). +circulation_biomarker_diagnosis_up 35879811 hsa-mir-204 Diabetic Foot 3p in peripheral blood and wound tissue of T2DM patients is closely related to the occurrence and poor wound healing of DFU. +transcription factor target 35879698 hsa-mir-29a Adenocarcinoma of Lung Subsequent experiments showed that miR-29a-3p could decrease the cell mobility and proliferation positive cell rates, as well as reduce the migratory and invasive possibilities in LUAD cells via downregulating C1QTNF6. CONCLUSION: Our study first demonstrated that downregulation of C1QTNF6 could inhibit tumorigenesis and progression in LUAD cells negatively regulated by miR-29a-3p. +circulation_biomarker_diagnosis_ns 35879425 hsa-mir-127 Osteoarthritis We validated the assay to detect circulating miR5p in synovial fluid, recently indicated as a predictive biomarker for osteoarthritis disease. +lncRNA target 35878746 hsa-mir-143 Intervertebral Disc Degeneration 3p inhibits the transcriptional activity of SOX5 through targeted binding, thereby inducing intervertebral disc degeneration. +transcription factor target 35878435 hsa-mir-132 Temporomandibular Joint Osteoarthritis 3p and PTEN in TMJOA was verified, and rescue experiments were conducted via co-upregulation of the expression of both miR +transcription factor target 35877720 hsa-mir-193a Drug Hypersensitivity At the molecular level, PEL and EPI induced apoptosis through the increase in pro-apoptotic BAX expression, confirmed by the decrease in its silencing miR +transcription factor target 35877720 hsa-mir-16 Drug Hypersensitivity At the molecular level, PEL and EPI induced apoptosis through the increase in pro-apoptotic BAX expression, confirmed by the decrease in its silencing miR +transcription factor target 35877720 hsa-mir-214 Drug Hypersensitivity At the molecular level, PEL and EPI induced apoptosis through the increase in pro-apoptotic BAX expression, confirmed by the decrease in its silencing miR +transcription factor target 35876890 hsa-mir-33a Carcinoma, Non-Small-Cell Lung We defined a signature of 13 miRNAs that strongly correlate with APE1 expression in human lung cancer: miR-1246, miR-4488, miR-24, miR-183, miR-660, miR-130b, miR-543, miR-200c, miR-376c, miR-218, miR-146a, miR-92b and miR-33a. Our findings, suggesting that APE1 modulates DICER1 expression via miR-33a and miR-130b, reveal new mechanistic insights on DICER1 regulation, which are of relevance in lung cancer chemoresistance and cancer invasiveness. +transcription factor target 35876890 hsa-mir-130b Carcinoma, Non-Small-Cell Lung We defined a signature of 13 miRNAs that strongly correlate with APE1 expression in human lung cancer: miR-1246, miR-4488, miR-24, miR-183, miR-660, miR-130b, miR-543, miR-200c, miR-376c, miR-218, miR-146a, miR-92b and miR-33a. Our findings, suggesting that APE1 modulates DICER1 expression via miR-33a and miR-130b, reveal new mechanistic insights on DICER1 regulation, which are of relevance in lung cancer chemoresistance and cancer invasiveness. +genetics_knock down_promote 35876480 hsa-mir-7 Keloid Circ_0057452 knockdown suppressed keloid development by regulating miR +other 35876391 hsa-mir-145 Breast Neoplasms For patients with luminal breast cancers, reduced Let-7a predicted achieving a pCR ( P =0.037) and reduced miR-145 predicted achieving a pCR to NAC in HER2+ ( P =0.027). +other 35876391 hsa-let-7a Breast Neoplasms For patients with luminal breast cancers, reduced Let-7a predicted achieving a pCR ( P =0.037) and reduced miR-145 predicted achieving a pCR to NAC in HER2+ ( P =0.027). +circulation_biomarker_diagnosis_ns 35876212 hsa-mir-8485 Heart Failure It was found that miR-8485 level was markedly reduced in the plasma of CHF patients, compared with the healthy controls. +lncRNA target 35876160 hsa-mir-377 Endometrial Neoplasms CONCLUSION: BBR was found to inhibit EC via the circ_ZNF608/miR3p/COX2 axis, which is helpful in endometrial carcinoma. +circulation_biomarker_diagnosis_ns 35876150 hsa-mir-607 Diabetes Mellitus, Type 2 The levels of lncRNA TUG1, hsa-miR-607 and hsa_circ_0071106 in peripheral blood have potential clinical diagnostic value for T2DM. +other 35876135 hsa-mir-96 Endometriosis CONCLUSIONS: Integrated bioinformatic analysis of the miRNA-mRNA co-expression network defines the crucial roles of the miR-200 family, miR-106a-363 cluster and miR-183/96/182 cluster in the pathogenesis of ovarian endometriosis. +other 35876135 hsa-mir-182 Endometriosis CONCLUSIONS: Integrated bioinformatic analysis of the miRNA-mRNA co-expression network defines the crucial roles of the miR-200 family, miR-106a-363 cluster and miR-183/96/182 cluster in the pathogenesis of ovarian endometriosis. +other 35876135 hsa-mir-183 Endometriosis CONCLUSIONS: Integrated bioinformatic analysis of the miRNA-mRNA co-expression network defines the crucial roles of the miR-200 family, miR-106a-363 cluster and miR-183/96/182 cluster in the pathogenesis of ovarian endometriosis. +circulation_biomarker_diagnosis_ns 35875355 hsa-mir-22 familial temporal lobe epilepsy 3 Moreover, the high area under the ROC curve (0.777; 95% CI 0.629-0.925; p = 0.001) suggests that low miR-22 serum levels may be a sensitive predictor of poor response to AEDs among MTLE-HS patients. +other 35875068 hsa-mir-34a Colorectal Neoplasms 5p/ZG16, and hsa-miRNA 3064-5p/SH3BGRL3, were identified in samples of adenoma, IMC, and CRC with the MSS phenotype. +other 35875068 hsa-mir-22 Colorectal Neoplasms In adenomatous lesions obtained from the same tumor with a carcinomatous lesion, we identified pairs of miRNA-130a-3p/HSPA8 and miRNA3p/RP53 that were linked to multiple pathways. +other 35875068 hsa-mir-130a Colorectal Neoplasms In adenomatous lesions obtained from the same tumor with a carcinomatous lesion, we identified pairs of miRNA-130a-3p/HSPA8 and miRNA3p/RP53 that were linked to multiple pathways. +other 35875068 hsa-mir-660 Colorectal Neoplasms On the other hand, 2 pairs of miRNA/mRNA (miRNA5p and miRNA-664a-5p/APP) were found in isolated carcinomatous glands. +other 35875068 hsa-mir-664a Colorectal Neoplasms On the other hand, 2 pairs of miRNA/mRNA (miRNA5p and miRNA-664a-5p/APP) were found in isolated carcinomatous glands. +circulation_biomarker_prognosis_up 35874900 hsa-mir-106 Atrial Fibrillation With the increase of the severity of atrial fibrillation, the level of serum miR-106 gradually increased and the level of MYL4 gradually decreased, which were statistically significant compared with the control group (P < 0.05). +transcription factor target 35874899 hsa-mir-22 Melanoma This work was to investigate mechanism by which mir-22 targeting nod-like receptor protein 3 (NLRP3) inflammasome affected activity of human skin malignant melanoma (MM) A375 cells. Therefore, miR-22 may target and inhibit the activation of the NLRP3 inflammasome to reduce the activity of cutaneous malignant melanoma A375 cells. +circRNA target 35874898 hsa-mir-30 Carcinoma, Non-Small-Cell Lung CONCLUSION: The current study revealed that circ_0000518 may have a prooncogenic function in the formation and progression of NSCLC, which might be achieved through moderating the miR3p/SLC1A5 axis. +lncRNA target 35874804 hsa-mir-622 Intervertebral Disc Degeneration These data suggested that circ_0005918 played important roles in the development of IDD via sponging miR-622. +transcription factor target 35874782 hsa-mir-100 Dacryocystitis CONCLUSION: Our data indicated that hUC-MSC-sEVs alleviated autoimmune dacryoadenitis by promoting M2 macrophage polarization and Treg generation possibly through shuttling miR5p. +target gene 35874630 hsa-mir-296 Colorectal Neoplasms Long Noncoding XLOC_006390 Regulates the Proliferation and Metastasis of Human Colorectal Cancer via miR-296/ONECUT2 Axis. +other 35873767 hsa-mir-133b Muscular Dystrophy, Duchenne In particular, miR-499, miR-208b, miR-133a, and miR-133b might have the ability to reflect the extent of muscle impairment. +other 35873767 hsa-mir-208b Muscular Dystrophy, Duchenne In particular, miR-499, miR-208b, miR-133a, and miR-133b might have the ability to reflect the extent of muscle impairment. +other 35873767 hsa-mir-499 Muscular Dystrophy, Duchenne In particular, miR-499, miR-208b, miR-133a, and miR-133b might have the ability to reflect the extent of muscle impairment. +other 35873767 hsa-mir-133a Muscular Dystrophy, Duchenne In particular, miR-499, miR-208b, miR-133a, and miR-133b might have the ability to reflect the extent of muscle impairment. +other 35873767 hsa-mir-1 Muscular Dystrophy, Duchenne In particular, miR-499, miR-208b, miR-133a, and miR-133b might have the ability to reflect the extent of muscle impairment. +genetics_overexpression_promote 35873641 hsa-mir-199 Cardiotoxicity In this study, overexpression of miR-199 could promote cardiotoxicity. +genetics_overexpression_promote 35873635 hsa-mir-28 Lymphoma, Large B-Cell, Diffuse The overexpression of hsa-miR +other 35873535 hsa-mir-21 Corneal Injuries CONCLUSION: HUMSC-sEVs could enhance the recovery of corneal epithelial wounds though restraining PTEN by transferring miR-21 and may represent a promising novel therapeutic agent for corneal wound repair. +other 35873535 hsa-mir-21 Corneal Ulcer CONCLUSION: HUMSC-sEVs could enhance the recovery of corneal epithelial wounds though restraining PTEN by transferring miR-21 and may represent a promising novel therapeutic agent for corneal wound repair. +other 35873473 hsa-mir-101 Urinary Bladder Neoplasms NEAT1/MALAT1/XIST/PKD--Hsa-Mir3p--DLGAP5 Axis as a Novel Diagnostic and Background: The clinical value of the biomarkers of bladder cancer (BC) is limited due to their low sensitivity or specificity. +circulation_biomarker_diagnosis_ns 35873157 hsa-mir-23b Acute-On-Chronic Liver Failure 5p, tsRNA-20, tsRNA-46, and rsRNA-249) were specifically differentially expressed in plasma exosomes of HBV-ACLF. +circulation_biomarker_diagnosis_ns 35873157 hsa-mir-339 Hepatitis B, Chronic 5p, tsRNA-20, tsRNA-46, and rsRNA-249) were specifically differentially expressed in plasma exosomes of HBV-ACLF. +circulation_biomarker_diagnosis_ns 35873157 hsa-mir-23b Hepatitis B, Chronic 5p, tsRNA-20, tsRNA-46, and rsRNA-249) were specifically differentially expressed in plasma exosomes of HBV-ACLF. +circulation_biomarker_diagnosis_ns 35873157 hsa-mir-223 Acute-On-Chronic Liver Failure 5p, tsRNA-20, tsRNA-46, and rsRNA-249) were specifically differentially expressed in plasma exosomes of HBV-ACLF. +circulation_biomarker_diagnosis_ns 35873157 hsa-mir-339 Acute-On-Chronic Liver Failure 5p, tsRNA-20, tsRNA-46, and rsRNA-249) were specifically differentially expressed in plasma exosomes of HBV-ACLF. +circulation_biomarker_diagnosis_ns 35873157 hsa-mir-223 Hepatitis B, Chronic 5p, tsRNA-20, tsRNA-46, and rsRNA-249) were specifically differentially expressed in plasma exosomes of HBV-ACLF. +genetics_overexpression_suppress 35873150 hsa-let-7 Influenza, Human We found that influenza A virus (IAV) infection caused a significant decrease of microRNA let-7 expression in host cells; that overexpression of let-7 increased interferon expression and effectively inhibit IAV infection; and that let-7 targets the 3'-untranslated region (UTR) of the ribosomal protein 16 (RPS16) gene, decreasing its expression. +other 35873003 hsa-mir-15a Obesity Using an in vivo reductionist approach and POMC(Cre)-dependent CRISPR-Cas9, we demonstrate that miR-15a-5p protects from obesity. +other 35872948 hsa-mir-424 Neurotoxicity Syndromes After exposure to ISO, induced neurotoxicity and a decreased miR5p production were identified in hESC-derived neurons. +other 35872948 hsa-mir-424 Nerve Degeneration Although miR5p is considerably downregulated in ISO-treated rat brain samples, its physiological role in ISO-induced neuronal injury in human embryonic stem cell-derived neurons remains unknown (hESC-derived neurons). +lncRNA target 35872931 hsa-mir-760 Lung Neoplasms The miR-760 and IDO1 levels in NSCLC were tested via real-time quantitative polymerase chain reaction (qRT-PCR) and western blotting (WB). +other 35872885 hsa-mir-223 Acute Coronary Syndrome An increased expression of miR-125a and miR-223 was found in patients with non-ST-segment elevation ACS (NSTE-ACS) as compared to those with ST-segment elevation myocardial infarction (STEMI) (p = 0.043 and p = 0.049, respectively) with no difference in the expression of miR-125b between the type of ACS. +other 35872885 hsa-mir-125a Acute Coronary Syndrome An increased expression of miR-125a and miR-223 was found in patients with non-ST-segment elevation ACS (NSTE-ACS) as compared to those with ST-segment elevation myocardial infarction (STEMI) (p = 0.043 and p = 0.049, respectively) with no difference in the expression of miR-125b between the type of ACS. +other 35872885 hsa-mir-223 Acute Coronary Syndrome An increased expression of miR-125a and miR-223 was found in patients with non-ST-segment elevation ACS (NSTE-ACS) as compared to those with ST-segment elevation myocardial infarction (STEMI) (p = 0.043 and p = 0.049, respectively) with no difference in the expression of miR-125b between the type of ACS. +other 35872885 hsa-mir-125b Acute Coronary Syndrome CONCLUSION: In this hypothesis generating study, lower values of miR-125b were related to improved long-term survival in patients with ACS and MVD. +other 35872885 hsa-mir-125b Acute Coronary Syndrome CONCLUSION: In this hypothesis generating study, lower values of miR-125b were related to improved long-term survival in patients with ACS and MVD. +other 35872885 hsa-mir-125a Acute Coronary Syndrome An increased expression of miR-125a and miR-223 was found in patients with non-ST-segment elevation ACS (NSTE-ACS) as compared to those with ST-segment elevation myocardial infarction (STEMI) (p = 0.043 and p = 0.049, respectively) with no difference in the expression of miR-125b between the type of ACS. +lncRNA target 35872873 hsa-mir-29a Keloid CONCLUSION: The miRNA-mRNA network, especially miR-29a-3p and its targets, may provide insights into the underlying pathogenesis of keloid and serve as potential biomarkers for keloid treatment. +lncRNA target 35872698 hsa-mir-339 Glioma 5p inhibitory functions in glioma through PTP4A1/HMGB1 pathway. +transcription factor target 35872695 hsa-mir-622 Stomach Neoplasms CONCLUSION: miR-622 and NUAK1 demonstrated potential for being targets and biomarkers for GC treatment. +lncRNA target 35872625 hsa-mir-588 Carcinoma, Non-Small-Cell Lung CONCLUSION: Circ_0010235 contributed to the malignant progression of NSCLC, but suppressed the radiation sensitivity via targeting miR- 588 to induce HOXA10 upregulation. +other 35872368 hsa-mir-433 Colorectal Neoplasms CONCLUSION: We first revealed PCGEM1/miR3p/CTCF positive feedback loop as an oncogenic axis in CRC cells, which potentially provides new clues for the advancement of CRC treatment. +tissue_expression_up 35872110 hsa-mir-9 Ataxia Neuropathy Spectrum These results showed that miR9-3 deficiency initiated the damage to the entire hematopoietic system. +tissue_expression_ns 35872110 hsa-mir-9 immunodeficiency 9 deficiency impaired the development of B cells in BM. +circRNA target 35871508 hsa-mir-106a Diabetic Nephropathies CONCLUSION: Our data indicated that circ_0068087 downregulation mitigated HG-induced HK2 cell injury through the miR-106a-5p/ROCK2 axis, providing a potential circRNA-targeted therapy for DN. +other 35871268 hsa-mir-149 Brain Ischemia Each group was divided into three subgroups to assess the volume of the tissue damage and neurological deficits scores (NDS) in subgroup 1, brain water content in subgroup 2, level of miRNA5p and CCC expressions in subgroup 3. +exosome 35870977 hsa-mir-106a Diabetic Foot Exosomal mmu_circ_0001052 was determined to sponge miR-106a-5p that targeted FGF4 in DFU. +genetics_overexpression_suppress 35869728 hsa-mir-223 Myelodysplastic Syndromes overexpression of miR-223-3p can effectively inhibit the expression of NLRP3 and cell pyroptosis in MDS. +transcription factor target 35869720 hsa-mir-218 Uterine Cervical Neoplasms As the second most common gynecological tumor in the world, cervical cancer has always been a female killer.Some studies have shown that miR-218 can inhibit the invasion and migration of cervical cancer cells through two target genes, SFMBT1and DCUNIDI. On this basis, this paper presents the study that miR-218 affects the invasion and migration of cervical cancer cells by inhibiting the expression of target genes, SFMBT1 and DCUNIDI. +genetics_overexpression_promote 35869716 hsa-mir-138 Breast Neoplasms For this aim, the endometrial stem breast cancer cell line MCF-7 was cultured in vitro, and the overexpression mimic miR-138 mimics and the inhibitor anti-miR-138 were transfected into the endometrial stem breast cancer cell line MCF-7, which was set to overexpress miR-138 group and interfere with miR-138, and set up negative control of overexpression and negative control of inhibitor. +genetics_knock down_promote 35869629 hsa-mir-28 Acute Kidney Injury Furthermore, we found that PT-METTL3-KO or METTL3 siRNA significantly suppressed ischemic, septic, and vancomycin-induced AKI via downregulation of the mmu-lncRNA 121686/miR +other 35869509 hsa-mir-127 Huntington Disease Using a panel of HD-related miRNAs (miR-10b, miR-196b, miR-132, miR-212, miR-127, miR-128), we uncovered various types of maturation defects in the HD brain, the most prominent occurring at the pre-miRNA to mature miRNA maturation step. +other 35869509 hsa-mir-212 Huntington Disease Using a panel of HD-related miRNAs (miR-10b, miR-196b, miR-132, miR-212, miR-127, miR-128), we uncovered various types of maturation defects in the HD brain, the most prominent occurring at the pre-miRNA to mature miRNA maturation step. +other 35869509 hsa-mir-196b Huntington Disease Using a panel of HD-related miRNAs (miR-10b, miR-196b, miR-132, miR-212, miR-127, miR-128), we uncovered various types of maturation defects in the HD brain, the most prominent occurring at the pre-miRNA to mature miRNA maturation step. +other 35869509 hsa-mir-132 Huntington Disease Using a panel of HD-related miRNAs (miR-10b, miR-196b, miR-132, miR-212, miR-127, miR-128), we uncovered various types of maturation defects in the HD brain, the most prominent occurring at the pre-miRNA to mature miRNA maturation step. +other 35869509 hsa-mir-10b Huntington Disease Using a panel of HD-related miRNAs (miR-10b, miR-196b, miR-132, miR-212, miR-127, miR-128), we uncovered various types of maturation defects in the HD brain, the most prominent occurring at the pre-miRNA to mature miRNA maturation step. +other 35868429 hsa-mir-29c Liver Diseases, Alcoholic miR-29c is differentially expressed in alcoholic liver disease. +other 35868352 hsa-mir-146 Leukemia-Lymphoma, Adult T-Cell Four miRNAs, including hsa-mir-146, hsa-mir-451, hsa-mir-31, and hsa-mir-125, were among the statistically significant differentially expressed miRNAs between healthy individuals and ATLL patients. +other 35868352 hsa-mir-125 Leukemia-Lymphoma, Adult T-Cell Four miRNAs, including hsa-mir-146, hsa-mir-451, hsa-mir-31, and hsa-mir-125, were among the statistically significant differentially expressed miRNAs between healthy individuals and ATLL patients. +other 35868352 hsa-mir-451 Leukemia-Lymphoma, Adult T-Cell Four miRNAs, including hsa-mir-146, hsa-mir-451, hsa-mir-31, and hsa-mir-125, were among the statistically significant differentially expressed miRNAs between healthy individuals and ATLL patients. +other 35868352 hsa-mir-1 Leukemia-Lymphoma, Adult T-Cell Four miRNAs, including hsa-mir-146, hsa-mir-451, hsa-mir-31, and hsa-mir-125, were among the statistically significant differentially expressed miRNAs between healthy individuals and ATLL patients. +lncRNA target 35868335 hsa-mir-148a Prostatic Neoplasms Finally, real-time PCR was used to evaluate the regulatory effects of curcumin and paclitaxel on miR-148a and its target genes. +genetics_GWAS 35867864 hsa-mir-221 Kidney Diseases In CKD 2-3 patients, elevation of FGF23 was associated with increased pulse wave velocity and reduced plasma levels of miR-221/222. +genetics_GWAS 35867864 hsa-mir-221 Juvenile gout In CKD 2-3 patients, elevation of FGF23 was associated with increased pulse wave velocity and reduced plasma levels of miR-221/222. +genetics_knock down_promote 35867177 hsa-mir-181a Liver Neoplasms Its levels were maintained in miR-181 KO liver tumours. +lncRNA target 35866931 hsa-mir-21 Osteoarthritis In a nutshell, our study reported that the anti-OA effects of Rb1 relied on the inhibited expression of miR +transcription factor target 35866896 hsa-mir-708 Osteomyelitis A bacteria-sensitive natural polymer hyaluronic-acid-based hydrogel (HA hydrogel) loaded with antagomiR5p exhibited promising effects in an in vivo study through antibacterial and pro-osteogenic differentiation functions in infected fractures. +circRNA target 35866672 hsa-mir-512 Lung Neoplasms 5p inhibited the malignant behaviors of lung cancer cells via downregulating KIAA0100. +other 35866630 hsa-mir-181d Inflammation Moreover, the regulatory relationships among circ_0035266, miR-181d-5p, and DDX3X were further confirmed using a group of lung cancer tissues. +lncRNA target 35866606 hsa-mir-335 Aortic Dissection 5p may be a potential therapeutic target in AD. +genetics_knock down_promote 35866595 hsa-mir-34b Adenocarcinoma of Lung Our study demonstrated that the regulation of RP11805J14.5 on LUAD was mediated by CCND2 whose expression was regulated by sponging miR34b3p and miR1395p. The expression of RP11805J14.5 was increased in LUAD, and the knockdown of RP11805J14.5 expression suppressed LUAD cell growth, invasion and migration by downregulating CCND2 by sponging miR34b3p and miR1395p, indicating that RP11805J14.5 could be a prospective target for LUAD therapy. +genetics_knock down_promote 35866595 hsa-mir-139 Adenocarcinoma of Lung Our study demonstrated that the regulation of RP11805J14.5 on LUAD was mediated by CCND2 whose expression was regulated by sponging miR34b3p and miR1395p. The expression of RP11805J14.5 was increased in LUAD, and the knockdown of RP11805J14.5 expression suppressed LUAD cell growth, invasion and migration by downregulating CCND2 by sponging miR34b3p and miR1395p, indicating that RP11805J14.5 could be a prospective target for LUAD therapy. +genetics_overexpression_promote 35866594 hsa-mir-491 Carcinoma, Non-Small-Cell Lung miR4913p overexpression suppressed the in vivo growth of NSCLC. +lncRNA target 35866591 hsa-mir-4429 Carcinoma, Renal Cell By intervening microRNA (miR)4492 and UBE2C by the transfection of miR4429mimics or short interfering UBE2C2, the regulatory effect of lncRNA FTX/miR4429/UBE2C axis on the progression of RCC was evaluated. Overall, the present study showed that lncRNA FTX was upregulated in RCC and could significantly promote the proliferative, migratory and invasive capacities, enhancing the viability and accelerating the cell cycle progression of RCC cells by exerting the miRNA sponge effect on miR4429 and thus upregulating UBE2C. +circRNA target 35865464 hsa-mir-27b Esophageal Squamous Cell Carcinoma CircLONP2 promotes ESCC aggressiveness by directly interacting with miR-27b-3p, thus upregulating the expression levels of its target gene ZEB1 by suppressing miR-27b-3p activity. Therefore, we demonstrated that circLONP2/miR-27b-3p/ZEB1 axis promotes ESCC metastasis via regulating epithelial-to-mesenchymal transition (EMT)-related proteins. +other 35865405 hsa-mir-34a Lymphoma, Mantle-Cell CONCLUSION: Upregulation of circCTNNA1 in MCL predicts poor survival of patients and it may sponge miR-34a to promote cancer cell proliferation. +transcription factor target 35865391 hsa-mir-21 Cardiomyopathies This study aimed to explore the roles of miR-208b, miR-21 and transforming growth factor-beta1 (TGF-beta1)/Smad-3 signaling pathway components in cardiac fibrosis development. CONCLUSION: MiR-208b and miR-21 promote cardiac fibrosis progression through TGF-beta1/Smad-3 signaling pathway activation. +transcription factor target 35865391 hsa-mir-208b Cardiomyopathies This study aimed to explore the roles of miR-208b, miR-21 and transforming growth factor-beta1 (TGF-beta1)/Smad-3 signaling pathway components in cardiac fibrosis development. CONCLUSION: MiR-208b and miR-21 promote cardiac fibrosis progression through TGF-beta1/Smad-3 signaling pathway activation. +transcription factor target 35865382 hsa-mir-21 Heart Failure, Chronic CONCLUSION: Paeonol shows a cardioprotective effect on DOX-induced CHF via regulating the miR +lncRNA target 35864972 hsa-mir-149 Cholangiocarcinoma These findings indicated that YY1-induced DLEU1 played a crucial role in CCA progression via miR +other 35864871 hsa-mir-23a Prostatic Neoplasms We also verified the SNHG17/miR-23a/OTUB1 axis in RV-1 and PC-3 cells by dual luciferase and RIP assays, and we further identified that SNHG17 promoted cellular invasive capacity by modulating OTUB1. +lncRNA target 35864552 hsa-mir-1 Urinary Bladder Neoplasms CONCLUSIONS: This study reveals the pro-metastatic and proliferative function of upregulated glycosyltransferase C1GLAT1, and provides preliminary data on mechanisms underlying dysregulation of C1GALT1 via miR +lncRNA target 35864549 hsa-mir-200b Adenocarcinoma of Lung CONCLUSIONS: We confirmed that MARCKSL1-2 alleviated DTX resistance in LAD cells by abolishing the inhibitory effect of HDAC1 on miR-200b via the recruitment of SUZ12. +circRNA target 35864511 hsa-mir-1307 Stomach Neoplasms RESULTS: CircDIDO1 inhibited GC progression by regulating the expression of the signal transducer inhibitor SOSC2 through sponging miR +circulation_biomarker_diagnosis_ns 35864328 hsa-mir-26 Atrial Fibrillation CONCLUSIONS: RFA helped to restore circulating levels of miR-26, which were reduced in atrial fibrillation. +other 35863536 hsa-mir-24 Growth Hormone-Secreting Pituitary Adenoma By profile sequencing, we further identified some antioxidant closely related miRNAs shared in the VE and PAP groups, including miR-30, miR-24, miR-19b, and miR-100. +other 35863536 hsa-mir-100 Growth Hormone-Secreting Pituitary Adenoma By profile sequencing, we further identified some antioxidant closely related miRNAs shared in the VE and PAP groups, including miR-30, miR-24, miR-19b, and miR-100. +genetics_knock down_promote 35863454 hsa-mir-1249 Carcinoma, Non-Small-Cell Lung CircHIPK2 knockdown or miR +circulation_biomarker_diagnosis_ns 35863239 hsa-mir-223 Cardiovascular Diseases Plasma EV miRNAs relevant to cardiovascular disease showed exposure-induced expression alterations, including miR-150, miR-183, miR3p, miR-30b, and miR-378a. +circulation_biomarker_diagnosis_ns 35863239 hsa-mir-183 Cardiovascular Diseases Plasma EV miRNAs relevant to cardiovascular disease showed exposure-induced expression alterations, including miR-150, miR-183, miR3p, miR-30b, and miR-378a. +circulation_biomarker_diagnosis_ns 35863239 hsa-mir-378a Cardiovascular Diseases Plasma EV miRNAs relevant to cardiovascular disease showed exposure-induced expression alterations, including miR-150, miR-183, miR3p, miR-30b, and miR-378a. +circulation_biomarker_diagnosis_ns 35863239 hsa-mir-150 Cardiovascular Diseases Plasma EV miRNAs relevant to cardiovascular disease showed exposure-induced expression alterations, including miR-150, miR-183, miR3p, miR-30b, and miR-378a. +exosome 35863089 hsa-mir-10a Leukemia, Myeloid, Acute Down-regulation of miR-10a substantially increase chemosensitivity of AML cells treated with BMSCs-Exos. +genetics_overexpression_promote 35862727 hsa-mir-27a Wilms Tumor In addition, overexpression of PBOV1 antagonized the tumor-suppressive effect of miR-27a-5p in Wilms' tumor cells. +other 35862485 hsa-mir-1343 Bovine Virus Diarrhea-Mucosal Disease In SER, the CO group had levels of miR3p significantly higher than the CT and MB groups (P = 0.0071). +other 35862468 hsa-mir-335 Hypertension, Pulmonary mediated downregulation of Vangl2 and thereby promoting the expression of Vangl2 to prevent PH. +genetics_knock down_promote 35862252 hsa-mir-137 Glioblastoma BACKGROUND: The loss of neurogenic tumor suppressor microRNAs miR-124, miR-128, and miR-137 is associated with glioblastoma's undifferentiated state. +genetics_knock down_promote 35862252 hsa-mir-128 Glioblastoma BACKGROUND: The loss of neurogenic tumor suppressor microRNAs miR-124, miR-128, and miR-137 is associated with glioblastoma's undifferentiated state. +genetics_knock down_promote 35862252 hsa-mir-124 Glioblastoma BACKGROUND: The loss of neurogenic tumor suppressor microRNAs miR-124, miR-128, and miR-137 is associated with glioblastoma's undifferentiated state. +other 35862223 hsa-mir-122 Angelman Syndrome 5p, which was related to cardiomyocyte dysfunction. +other 35862223 hsa-mir-26a Angelman Syndrome 5p, and miR-1274) were significantly deregulated in patients with aortic valve stenosis at day 7 after TAVR compared with the preprocedural levels in patients without LVEF improvement. +other 35862223 hsa-mir-1274 Angelman Syndrome 5p, and miR-1274) were significantly deregulated in patients with aortic valve stenosis at day 7 after TAVR compared with the preprocedural levels in patients without LVEF improvement. +other 35862223 hsa-mir-192 Angelman Syndrome 5p, and miR-1274) were significantly deregulated in patients with aortic valve stenosis at day 7 after TAVR compared with the preprocedural levels in patients without LVEF improvement. +circRNA target 35861841 hsa-mir-340 Pulmonary Arterial Hypertension 5p to aggravate PH progression by promoting TCF4/beta-catenin/TWIST1 complex, which may provide potential therapeutic targets for PH. +genetics_knock down_promote 35861544 hsa-mir-133b Uterine Cervical Neoplasms Downregulation of miR-133b partly reversed the DDP sensitivity of circ_0005273 knockdown in DDP-resistant CC cells. +circulation_biomarker_diagnosis_ns 35860808 hsa-mir-1246 Intracranial Aneurysm PRINCIPLE FINDINGS AND RESULTS: Serum levels of miR-1246 were elevated in intracranial aneurysm patients. +other 35860691 hsa-mir-26a Carcinoma, Non-Small-Cell Lung METHODS: The expression of miR-26a-5p in NSCLC cell lines was detected by qPCR and verified in NSCLC tissues from TCGA using Limma R package. RESULTS: The expression of miR-26a-5p was downregulated in the tumor tissues comparted to adjacent normal tissues as well as NSCLC cell lines compared to normal lung epithelial cell (BEAS2B). +lncRNA target 35860558 hsa-mir-6747 Small Cell Lung Carcinoma lncRNAs (lncRNA-AC005005.4-201 and NEAT1-203) and circRNAs (circRNA-hsa_HLA-B_1 and hsa_VEGFC_8) may regulate the inhibited effects of hsa-miR +lncRNA target 35860558 hsa-mir-4525 Small Cell Lung Carcinoma lncRNAs (lncRNA-AC005005.4-201 and NEAT1-203) and circRNAs (circRNA-hsa_HLA-B_1 and hsa_VEGFC_8) may regulate the inhibited effects of hsa-miR +tissue_expression_ns 35860182 hsa-mir-495 Sepsis OBJECTIVE: This study is aimed at evaluating the miR3p and miR3p expression in the urine of patients with sepsis-associated acute kidney injury (SA-AKI) and exploring its diagnosis value in for SA-AKI. ROC curve was performed to evaluate the diagnostic value of miR3p and miR3p for SA-AKI. The prognostic performance of miR3p and miR3p for SA-AKI was evaluated by survival curves. RESULTS: Compared with non-AKI invalids, miR3p and miR3p expressions were obviously lower in the urine of AKI invalids. Furthermore, the area under the curve (AUC) of miR3p and miR3p for diagnosing sepsis SA-AKI was 0.896 and 0.814, respectively. CONCLUSIONS: A novel biomarker for the early diagnosis of SA-AKI may be miR3p and miR3p, which was clearly reduced in the urine of SA-AKI patients. +tissue_expression_ns 35860182 hsa-mir-370 Sepsis OBJECTIVE: This study is aimed at evaluating the miR3p and miR3p expression in the urine of patients with sepsis-associated acute kidney injury (SA-AKI) and exploring its diagnosis value in for SA-AKI. ROC curve was performed to evaluate the diagnostic value of miR3p and miR3p for SA-AKI. The prognostic performance of miR3p and miR3p for SA-AKI was evaluated by survival curves. RESULTS: Compared with non-AKI invalids, miR3p and miR3p expressions were obviously lower in the urine of AKI invalids. Furthermore, the area under the curve (AUC) of miR3p and miR3p for diagnosing sepsis SA-AKI was 0.896 and 0.814, respectively. CONCLUSIONS: A novel biomarker for the early diagnosis of SA-AKI may be miR3p and miR3p, which was clearly reduced in the urine of SA-AKI patients. +transcription factor target 35860039 hsa-mir-142 Diabetic Retinopathy Subsequently, through analyzing GSE84216 from the GEO database, miR5p was markedly upregulated by treatment of muscone in this cell model of cerebral hypoxia injury. +lncRNA target 35860023 hsa-mir-148b Acute Kidney Injury Additionally, Virofree elevated miR-148b-5p levels, inhibited the main protease of SARS-CoV-2 (M(pro)), and reduced LPS-induced TNF-alpha release. +genetics_overexpression_suppress 35859793 hsa-mir-100 Thyroid Cancer, Papillary Thus, we suggest that overexpression of miR +exosome 35859725 hsa-mir-122a Fibrosis, Renal These findings indicate that the export of miRNA-122a via MSC-derived exosomes represents a novel strategy to alleviate renal fibrosis. +other 35859315 hsa-mir-137 Inhalant Abuse In vitro experiments with Neuro2a cells showed that miR3p inversely regulated Nr3c1 mRNA expression, which was upregulated in the HAL group. +lncRNA target 35858900 hsa-mir-4739 Carcinoma, Hepatocellular CONCLUSION: Our results demonstrate that circGPR137B inhibits HCC tumorigenesis and metastasis through the circGPR137B/miR-4739/FTO feedback loop. +exosome 35858897 hsa-mir-148a Liver Cirrhosis Administration of miR-148a-enriched MSC-EXOs or miR-148a agomir shows potent ameliorative effects on liver fibrosis. CONCLUSIONS: These findings suggest that MSC-EXOs protect against liver fibrosis via delivering miR-148a that regulates intrahepatic macrophage functions through KLF6/STAT3 signaling and provide a potential therapeutic target for liver fibrosis. +target gene 35858224 hsa-mir-372 Prostatic Neoplasms PRDM16, negatively regulated by miR-372-3p, suppresses cell proliferation and invasion in prostate cancer. +exosome 35857905 hsa-mir-20a Carcinoma, Non-Small-Cell Lung CONCLUSION: The achieved outcomes explain that CAFs can release miR-20a-containing exosomes capable of promoting NSCLC progression and chemoresistance, highlighting this pathway as a possible therapeutic target in NSCLC. +other 35857794 hsa-mir-552 Angelman Syndrome SKI axis played critical roles in the proliferation and migration of HBVSMCs and mVSMCs, which were closely involved in atherosclerosis (AS). +other 35857780 hsa-mir-27a Pyelonephritis Six additional miRNAs (miR-30b-5p, miR-30c, miR-30e-5p, miR-27a-3p, miR-27b-39 and miR-222) relevant for discriminating PN from other urological conditions were identified by qPCR alone (n = 4) or by both methods (n = 2) (P<0.05). +other 35857780 hsa-mir-222 Pyelonephritis Six additional miRNAs (miR-30b-5p, miR-30c, miR-30e-5p, miR-27a-3p, miR-27b-39 and miR-222) relevant for discriminating PN from other urological conditions were identified by qPCR alone (n = 4) or by both methods (n = 2) (P<0.05). +other 35857780 hsa-mir-27b Pyelonephritis Six additional miRNAs (miR-30b-5p, miR-30c, miR-30e-5p, miR-27a-3p, miR-27b-39 and miR-222) relevant for discriminating PN from other urological conditions were identified by qPCR alone (n = 4) or by both methods (n = 2) (P<0.05). +exosome 35856505 hsa-mir-145 Diabetic Retinopathy We have also investigated 484 miRNAs in tear exosomes and show miR +exosome 35856505 hsa-mir-9 Diabetic Retinopathy We have also investigated 484 miRNAs in tear exosomes and show miR +exosome 35856505 hsa-mir-214 Diabetic Retinopathy We have also investigated 484 miRNAs in tear exosomes and show miR +exosome 35856505 hsa-mir-218 Diabetic Retinopathy We have also investigated 484 miRNAs in tear exosomes and show miR +genetics_overexpression_suppress 35856354 hsa-mir-429 Carcinoma, Pancreatic Ductal The overexpression of miR-429 significantly inhibited the proliferation, invasion, and migration of PDAC cells. +circRNA target 35856314 hsa-mir-876 Breast Neoplasms 3p/ACTN4 axis, hinting at a promising therapeutic target for the BC treatment. +other 35855852 hsa-mir-26b Carcinoma, Hepatocellular Moreover, we identified a potential lncRNA TUG1/miR-26b-5p/EZH2 regulatory axis in LIHC, which might affect the progression of LIHC. And our study also identified a lncRNA TUG1/miR-26b-5p/EZH2 regulatory axis, which might be of great significance in LIHC progression. +lncRNA target 35855826 hsa-mir-373 Glioma CONCLUSIONS: ASP suppresses the malignant progression of glioma via regulating the miR +transcription factor target 35855629 hsa-mir-550a Atherosclerosis Thus, miR-550a-3p might play a role in atherosclerosis and, for the first time, normalised the function of injured vascular endothelial cells by simultaneous transfection of TM and miR-550a-3p. These results suggest that the miR-550a-3p/TM axis is a potential therapeutic target for atherosclerosis. +exosome 35854778 hsa-mir-766 Colorectal Neoplasms 5p/TRIM67 axis. +circulation_biomarker_diagnosis_down 35854669 hsa-let-7a Cleft Palate, Non-Syndromic 5p) in plasma exosomes from pregnant women provided higher sensitivity/specificity for diagnosing fetal nsCLP than those in plasma. +genetics_knock down_promote 35853821 hsa-mir-29c Carcinoma, Hepatocellular Moreover, ADAM12 knockout or p53 overexpression reduced HCC tumor formation and metastasis, which were reversed by further silencing of miR-29c-3p. +lncRNA target 35853537 hsa-mir-495 Carcinoma, Non-Small-Cell Lung 3p reprograms sphingolipid rheostat towards ceramide by targeting Sphk1 and induces lethal mitophagy to suppress NSCLC tumorigenesis. +lncRNA target 35853280 hsa-mir-20a Crohn Disease CONCLUSIONS: Downregulation of miR-20a-5p improved the intestinal epithelial barrier function and prevented CD development through the STAT3/IL-17 signaling pathway. +lncRNA target 35852716 hsa-mir-212 Brain Diseases 5p, aggravated the injury and apoptosis of brain and hippocampus tissues through regulating AKT/GSK3beta/beta-catenin signaling pathway under the CO-poisoning and OGD-treated model, suggesting a selected therapeutic target of DEACMP. +other 35852605 hsa-mir-451b Glioma 3p (p<0.0001), and microRNA-451b (p<0.0001) in glioma patients compared to controls. +other 35852605 hsa-mir-206 Glioma 3p (p<0.0001), and microRNA-451b (p<0.0001) in glioma patients compared to controls. +other 35852605 hsa-mir-4477a Glioma 3p (p<0.0001), and microRNA-451b (p<0.0001) in glioma patients compared to controls. +other 35852605 hsa-mir-4796 Glioma 3p (p<0.0001), and microRNA-451b (p<0.0001) in glioma patients compared to controls. +other 35852605 hsa-mir-4311 Glioma 3p (p<0.0001), and microRNA-451b (p<0.0001) in glioma patients compared to controls. +other 35852605 hsa-mir-4795 Glioma 3p (p<0.0001), and microRNA-451b (p<0.0001) in glioma patients compared to controls. +genetics_overexpression_promote 35852131 hsa-mir-602 Stomach Neoplasms Overexpression of HITT further increased GC cell apoptosis and suppressed the role of miR-602 in inhibiting GC cell apoptosis. +circRNA target 35852112 hsa-mir-940 Prostatic Neoplasms, Castration-Resistant Conclusion: hsa_circ_0092339 plays a critical role in CRPC through targeting C-MYC indirectly by absorbing hsa-mir-940. +transcription factor target 35851970 hsa-mir-125b Leukemia, Myeloid, Acute We also load CD33-targeting RBCEVs with antisense oligonucleotides (ASOs) targeting FLT3-ITD or miR-125b, 2 common oncogenes in AML, and demonstrate that the engineered EVs improve leukaemia suppression in in vitro and in vivo models of AML. +other 35851561 hsa-mir-191 Pancreatic Carcinoma The results showed that though LR model used to classify this data did not perform well as expected, miRNA-191 and miRNA-4306 still had high recalls (sensitivity), which laid a theoretical foundation for the purpose of using LR model to identify these two miRNAs to jointly diagnose of pancreatic cancer at miRNA level. +other 35851561 hsa-mir-4306 Pancreatic Carcinoma The results showed that though LR model used to classify this data did not perform well as expected, miRNA-191 and miRNA-4306 still had high recalls (sensitivity), which laid a theoretical foundation for the purpose of using LR model to identify these two miRNAs to jointly diagnose of pancreatic cancer at miRNA level. +lncRNA target 35851058 hsa-let-7c Mouth Neoplasms Mechanistically, miR-let-7c in OSCC-derived sEVs is transferred to normal epithelial cells, leading to the transcriptional inhibition of p53 and inactivation of the p53/PTEN pathway. In summary, we demonstrate that OSCC-derived sEVs promote the precancerous transformation of normal epithelial cells, in which the miR-let-7c/p53/PTEN pathway plays an important role. +other 35850658 hsa-mir-224 Pituitary Diseases CONCLUSION: This indicated a role of hepatic EVs identified by the miR5p in endothelial dysfunction in patients with Low CFR. +other 35850524 hsa-mir-4284 Triple Negative Breast Neoplasms Innovation: We identified a novel role for miR-4284 in regulating mitochondrial basal proton leak in TNBC cells, and highlighted its significance in TNBC tumor oxidative DNA damage, and its direct correlation with TNBC patient survival. +genetics_knock down_suppress 35850243 hsa-mir-125a Triple Negative Breast Neoplasms SIGNIFICANCE: These results indicate that knockdown of ANRIL plays an active role in overcoming drug resistance in TNBC by inhibiting glycolysis through the miR-125a/ENO1 pathway, which may be useful for the development of novel therapeutic targets for treating patients with TNBC, especially those with drug resistance. +other 35850198 hsa-mir-210 Colorectal Neoplasms A combination signature of these 4 miRNAs (miR-193a-5p, miR-210, miR-513a-5p, and miR3p) yielded an area under the curve of 0.92 (95% confidence interval, 0.85-0.96) for identification of EOCRC in the training cohort. +other 35850198 hsa-mir-193a Colorectal Neoplasms A combination signature of these 4 miRNAs (miR-193a-5p, miR-210, miR-513a-5p, and miR3p) yielded an area under the curve of 0.92 (95% confidence interval, 0.85-0.96) for identification of EOCRC in the training cohort. +genetics_knock down_promote 35849320 hsa-mir-197 Glioblastoma 3p inhibitor abolished the effect of circ_0060055 knockdown on GBM cell growth, invasion, and radiosensitivity. +circRNA target 35848890 hsa-mir-326 Carcinoma, Non-Small-Cell Lung Mechanistically, circ_001678 led to the activation of the PD-1/PD-L1 pathway to promote CD8+ T cell apoptosis, thereby inducing NSCLC cell immune escape via regulation of the miR-326/ZEB1 axis. To conclude, our findings revealed that circ_001678 sponges miR-326 to up-regulate ZEB1 expression and induce the PD-1/PD-L1 pathway-dependent immune escape, thereby promoting the malignant progression of NSCLC. +genetics_overexpression_promote 35848848 hsa-mir-146a Osteoarthritis Overexpression of miR-146a-5p also reversed the function of BMPR2 overexpression in OA. +transcription factor target 35848125 hsa-mir-21 Colorectal Neoplasms Together, our data indicated that a natural product, such as tangeretin, can modulate miR-21 expression and that this pathway might be a potential therapeutic target for CRC. +other 35847962 hsa-mir-192 Carcinoma, Hepatocellular CircKIF5B Promotes Hepatocellular Carcinoma Progression by Regulating the miR-192 Family/XIAP Axis. +transcription factor target 35847904 hsa-mir-200a Carcinoma, Hepatocellular Targeting miR-200a-3p and the miR5p/HOXB5/EGFR signaling pathway may provide new options for the treatment strategies of HCC. +genetics_overexpression_suppress 35847592 hsa-mir-27b Myocardial Reperfusion Injury This study is aimed at investigating the effect and mechanism of miR-27b-3p underlying hypoxic CMECs-derived exosomes against I/R injury. CONCLUSIONS: These results demonstrated a great therapeutic efficacy of miR-27b-3p overexpression in hypoxic CMEC-derived exosomes in preventing the development of myocardial damage post I/R injury through inhibiting Foxo1/GSDMD signaling-induced oxidative stress and pyroptosis. +circulation_biomarker_diagnosis_ns 35847565 hsa-mir-124 Carotid Stenosis Moreover, the CEUS parameters combined with serum miR-124 level could improve the performance in predicting ACI and had auxiliary value in evaluating the stability of carotid atherosclerotic plaques. +circulation_biomarker_diagnosis_ns 35847565 hsa-mir-124 Cerebral Infarction, Acute Moreover, the CEUS parameters combined with serum miR-124 level could improve the performance in predicting ACI and had auxiliary value in evaluating the stability of carotid atherosclerotic plaques. +target gene 35847361 hsa-mir-193a Uterine Cervical Neoplasms Circular RNA circACAP2 Suppresses Ferroptosis of Cervical Cancer during Malignant Progression by miR-193a-5p/GPX4. +lncRNA target 35847359 hsa-mir-216a Colonic Neoplasms The predicted target genes of the LINC00114/miR-216a-5p axis include uromodulin Like 1 (UMODL1) and oncoprotein induced transcript 3 (OIT3), which are closely related to the survival and prognosis of COAD patients. +other 35846077 hsa-mir-146a Carcinoma, Renal Cell Association analysis of rs2910164 in the miRNA-146a gene demonstrated that CC genotype and C allele carriers had higher risk of developing severe irAEs (p = 0.03, OR = 6.12; p = 0.01, OR = 2.42, respectively) compare with GG and GC carriers. +other 35846077 hsa-mir-146a Immune System Diseases Association analysis of rs2910164 in the miRNA-146a gene demonstrated that CC genotype and C allele carriers had higher risk of developing severe irAEs (p = 0.03, OR = 6.12; p = 0.01, OR = 2.42, respectively) compare with GG and GC carriers. +circulation_biomarker_diagnosis_down 35845963 hsa-mir-16 Sepsis The area under curve (AUC) of serum miR-4299 and miR +circulation_biomarker_diagnosis_down 35845963 hsa-mir-4299 Sepsis The area under curve (AUC) of serum miR-4299 and miR +genetics_knock down_promote 35845947 hsa-mir-497 Colonic Neoplasms Finally, our gain- and loss-of-function experiments evidenced that the lncRNA FGD5-AS1/miR +other 35845940 hsa-mir-182 Small Cell Lung Carcinoma Furthermore, IHC and qPCR outcomes showed that the expression level of hsa-miR-182, hsa-miR-183, and IGF2BP3 was differentially expressed in normal lung tissues (NLTs) and SCLC tissues (SCLCTs). CONCLUSIONS: Our results concluded that hsa-miR-182, hsa-miR-183, and IGF2BP3 may take part in the development of SCLC. +other 35845940 hsa-mir-183 Small Cell Lung Carcinoma Furthermore, IHC and qPCR outcomes showed that the expression level of hsa-miR-182, hsa-miR-183, and IGF2BP3 was differentially expressed in normal lung tissues (NLTs) and SCLC tissues (SCLCTs). CONCLUSIONS: Our results concluded that hsa-miR-182, hsa-miR-183, and IGF2BP3 may take part in the development of SCLC. +lncRNA target 35845923 hsa-mir-100 Ovarian Failure, Premature NOX4/NLRP3 signaling pathway affects the role of HUCMSCs in an in vitro model of premature ovarian failure through miR +other 35845594 hsa-mir-9 Squamous Cell Carcinoma of Head and Neck 5p may play core roles in the regulation of these three genes in HNSCC. +other 35845594 hsa-mir-335 Squamous Cell Carcinoma of Head and Neck 5p may play core roles in the regulation of these three genes in HNSCC. +lncRNA target 35845501 hsa-mir-99a Uterine Cervical Neoplasms This study sought to investigate the predictive value of miR-99a for lymphogenous spread and its effect on the survival of patients with early-stage cervical squamous cell cancer (CSCC). CONCLUSIONS: MiR-99a plays an inhibitory role in the pathogenesis of lymph node metastasis and may serve as a novel prognostic biomarker for patients with CSCC. +genetics_overexpression_suppress 35845132 hsa-mir-590 Melanoma 5p is underexpressed in melanoma cells, and its overexpression can inhibit Skp2 expression and proliferation and invasion of melanoma cells. +target gene 35845114 hsa-mir-26b Ovarian Neoplasms microRNA-26b inhibits growth and cellular invasion of ovarian cancer cells by targeting estrogen receptor alpha. +other 35845108 hsa-mir-200c Urinary Bladder Neoplasms Downregulation of NOTCH1 by hsa-mir-200c/mir-141 may also sensitize tumors to methotrexate thus suggesting potential chemotherapeutic options for bladder cancer subjects. +other 35845108 hsa-mir-141 Urinary Bladder Neoplasms Downregulation of NOTCH1 by hsa-mir-200c/mir-141 may also sensitize tumors to methotrexate thus suggesting potential chemotherapeutic options for bladder cancer subjects. +transcription factor target 35845054 hsa-mir-206 Diabetes Mellitus, Type 2 CONCLUSIONS: Our results indicate that both exercise protocols, HIIT and MICT, have the potential to reduce diabetic cardiomyopathy by modifying the expression of miR-206 and its downstream targets of apoptosis. +lncRNA target 35844793 hsa-mir-199a Carcinoma, Non-Small-Cell Lung Collectively, these results prove that miR-199a-3p/5p can act as cancer suppressor genes to inhibit the mTOR signaling pathway by targeting Rheb, which in turn inhibits the regulatory process of NSCLC. +circulation_biomarker_diagnosis_up 35844239 hsa-mir-21 Postural Orthostatic Tachycardia Syndrome In the 60-member validation group, the 13 miRNAs were verified again, and it turned out that miR-21 was significantly elevated and could diagnose POTS with a 100% specificity and 92.5% sensitivity. CONCLUSION: Elevated whole-blood miR-21 levels serve as an indicator for POTS and may explain the increased plasma H(2)S observed in POTS sufferers. +genetics_overexpression_promote 35844201 hsa-mir-143 Stomach Neoplasms 3p inhibition or PTBP3 overexpression. +exosome 35844005 hsa-mir-579 Nasopharyngeal Carcinoma * Exosomes loaded with circPARD3 promotes EBV-miR-BART4-induced NPC-SP cell stemness and resistance by the miR +virus_miRNA 35844005 ebv-mir-BART4 Nasopharyngeal Carcinoma Exosomes loaded with circPARD3 promoted EBV-miR-BART4-induced stemness and cisplatin resistance in NPC-SP cells through the miR-579-3p/SIRT1/SSRP1 axis. +other 35843524 hsa-mir-451 Sepsis MiR-451 involved in septicemia progression has been reported. However, the underlying mechanism of miR-451 in septicemia induced inflammatory response remains to be revealed. +circulation_biomarker_diagnosis_ns 35843386 hsa-mir-1294 Polycystic Ovary Syndrome CONCLUSIONS: Plasma miR-1294 along with members of the miR-17/92 cluster and miRNAs involved in insulin signaling may be associated with central obesity and insulin resistance in PCOS. +other 35842702 hsa-mir-502 Carcinoma, Renal Cell CONCLUSIONS: COLGALT1 could act as a valid immune-related prognostic indicator for KIRC and participated in a ceRNA network of SLC16A1-AS1/hsa-mir3p/COLGALT1, offering one potential biomarker to investigate the mechanism and clinical therapeutic value of KIRC. +genetics_overexpression_promote 35842667 hsa-mir-761 Esophageal Neoplasms Overexpression of FOXM1 or inhibiting miR-761 restored ESCC cell proliferation and invasion ability after silencing circ-ARAP2. In one word, the results demonstrated that abnormal circ-ARAP2 expression promoted ESCC progression by regulating miR-761/FOXM1 axis-mediated stemness and EMT. +lncRNA target 35842617 hsa-mir-218 Adenocarcinoma of Lung CONCLUSIONS: Linc00511 acts as a competing endogenous RNA to regulate COL1A1 by targeting miR +lncRNA target 35842617 hsa-mir-126 Adenocarcinoma of Lung CONCLUSIONS: Linc00511 acts as a competing endogenous RNA to regulate COL1A1 by targeting miR +other 35841247 hsa-mir-134 Alzheimer Disease Mesenchymal Stem Cells Modulate SIRT1/MiR-134/ GSK3 Signaling Pathway in a Rat Prolonged exposure to environmental aluminum-containing substances is associated with the development of Alzheimer's disease (AD). +lncRNA target 35841066 hsa-mir-574 Pancreatic Beta-Cell Dysfunction CONCLUSIONS: miR3p suppresses glucose toxicity-induced pancreatic beta-cell dysfunction by targeting PRMT1. +exosome 35841008 hsa-mir-23a Anterior Cruciate Ligament Injuries CONCLUSIONS: BMSC-Exos promoted M1 macrophage to M2 macrophage polarization via miR-23a-3p, reduced the early inflammatory reaction at the tendon-bone interface, and promoted early healing after ACLR. +transcription factor target 35841005 hsa-mir-132 Cognition Disorders CONCLUSIONS: Our studies suggest that miR3p cluster-enriched MSC EX promotes the recovery of cognitive function by improving neuronal and synaptic dysfunction through activation of the Ras/Akt/GSK-3beta pathway induced by downregulation of RASA1. +transcription factor target 35841005 hsa-mir-132 Dementia, Vascular CONCLUSIONS: Our studies suggest that miR3p cluster-enriched MSC EX promotes the recovery of cognitive function by improving neuronal and synaptic dysfunction through activation of the Ras/Akt/GSK-3beta pathway induced by downregulation of RASA1. +lncRNA target 35840974 hsa-mir-27a Esophageal Squamous Cell Carcinoma CONCLUSION: Our research demonstrated that splicing factor QKI promotes circBCAR3 biogenesis, which accelerates esophageal cancer tumorigenesis via binding with miR-27a-3p to upregulate TNPO1. CircBCAR3 promoted the proliferation, migration, invasion, and ferroptosis of esophageal cancer cells by miR-27a-3p. +other 35840955 hsa-mir-185 Intervertebral Disc Degeneration 5p-SMAD2. +lncRNA target 35840896 hsa-mir-34a Cervical Cancer, Hpv Infected In this study, we report that a micro-RNA, miR-34a by suppressing HPV E6 protein, destabilizes Cdt2/DTL protein level in HPV infected cervical cancer cell lines. This study is the first-ever report to show that miR-34a regulates cell cycle factor Cdt2 by suppressing viral E6 protein level, thus opening up the possibility of exploring miR-34a as a specific therapy for cervical cancer treatment. +lncRNA target 35840794 hsa-mir-365b Multiple Myeloma Targets for two specific miRNAs, miR-125b-5p and miR-365b-3p, were functionally validated in MM cell line transfection experiments followed by RNA-sequencing and qPCR. +lncRNA target 35840794 hsa-mir-125b Multiple Myeloma Targets for two specific miRNAs, miR-125b-5p and miR-365b-3p, were functionally validated in MM cell line transfection experiments followed by RNA-sequencing and qPCR. +other 35840467 hsa-mir-589 Triple Negative Breast Neoplasms 5p/ HDAC3 axis could be considered as a possible therapeutic strategy in TNBC. +circulation_biomarker_diagnosis_ns 35840148 hsa-mir-155 Arthritis, Juvenile 5p and miR-451a, compared to JIA plasma. +circulation_biomarker_diagnosis_ns 35840148 hsa-mir-451a Arthritis, Juvenile 5p and miR-451a, compared to JIA plasma. +circulation_biomarker_diagnosis_ns 35840148 hsa-mir-192 Arthritis, Juvenile 5p and miR-451a, compared to JIA plasma. +circulation_biomarker_diagnosis_ns 35840148 hsa-mir-146b Arthritis, Juvenile 5p and miR-451a, compared to JIA plasma. +circulation_biomarker_diagnosis_ns 35840148 hsa-mir-21 Arthritis, Juvenile 5p and miR-451a, compared to JIA plasma. +circulation_biomarker_diagnosis_ns 35840148 hsa-mir-27a Arthritis, Juvenile 5p and miR-451a, compared to JIA plasma. +genetics_knock down_promote 35839610 hsa-mir-33a Colorectal Neoplasms Moreover, CRC cell invasion and migration as well as xenograft CRC tumor growth suppressed by RASSF8-AS1 overexpression were entirely recovered by RASSF8 knockdown or partially rescued by miR-33a-5p augment. CONCLUSION: RASSF8-AS1 modulates miR-33a-5p/HNRNPC/RASSF8 axis to further impede CRC cell invasion and migration. +genetics_knock down_suppress 35839486 hsa-mir-582 Carcinoma, Hepatocellular 3p-knockdown-mediated promotion of malignant HCC cell phenotypes. +genetics_overexpression_promote 35839114 hsa-mir-17 Stomach Neoplasms 5p on the biological behavior of gastric cancer at the cellular level, by constructing a gastric-cancer cell model that uses overexpressing miR +genetics_knock down_promote 35839011 hsa-mir-194 Osteoporosis NCF2-Leukocyte transendothelial migration were involved in osteoporosis pathogenesis. +lncRNA target 35838912 hsa-mir-208 Melanoma Moreover, lncRNA MEG3 inhibited cancer stem cell differentiation and suppressed melanoma progression and metastasis through inhibition of miR-208 by SOX4. +genetics_GWAS 35838216 hsa-mir-124 Depression Genetic knockdown of hippocampal miR-124 produced significant antidepressant-like effects in the CSDS model of depression. +lncRNA target 35838051 hsa-mir-223 Hepatitis, Alcoholic RNA-Seq analysis and the data from experimental models revealed that neutrophilic NCF1-dependent ROS promoted alcoholic hepatitis (AH) by inhibiting AMP-activated protein kinase (a key regulator of lipid metabolism) and microRNA-223 (a key antiinflammatory and antifibrotic microRNA). +lncRNA target 35838051 hsa-mir-223 Liver Injury RNA-Seq analysis and the data from experimental models revealed that neutrophilic NCF1-dependent ROS promoted alcoholic hepatitis (AH) by inhibiting AMP-activated protein kinase (a key regulator of lipid metabolism) and microRNA-223 (a key antiinflammatory and antifibrotic microRNA). +genetics_overexpression_promote 35837990 hsa-mir-630 Carcinoma, Non-Small-Cell Lung Whereas, VIM overexpression partly attenuated the inhibitory effect of miR-630 on NSCLC cells. +other 35837786 hsa-mir-103 Diabetic Foot To investigate the relationship between small noncoding microRNA-103 (miR-103) and wound healing of diabetic foot ulcers (DFU) and the underlying molecular mechanism, forty type 2 diabetes mellitus with DFU (DFU group), and 20 patients with a chronic skin ulcer of lower limbs and normal glucose tolerance (SUC group) were included. +other 35837763 hsa-mir-23a Heart Failure 3p (HR 2.03 per 1 SD increase, P < 0.001) were able to accurately predict the primary outcome, as well as cardiovascular death, HF hospitalizations, and long-term New York Heart Association (NYHA) functional class. +other 35837763 hsa-mir-210 Myocardial Infarction, Acute 3p (HR 2.03 per 1 SD increase, P < 0.001) were able to accurately predict the primary outcome, as well as cardiovascular death, HF hospitalizations, and long-term New York Heart Association (NYHA) functional class. +other 35837763 hsa-mir-210 Heart Failure 3p (HR 2.03 per 1 SD increase, P < 0.001) were able to accurately predict the primary outcome, as well as cardiovascular death, HF hospitalizations, and long-term New York Heart Association (NYHA) functional class. +other 35837763 hsa-mir-221 Myocardial Infarction, Acute 3p (HR 2.03 per 1 SD increase, P < 0.001) were able to accurately predict the primary outcome, as well as cardiovascular death, HF hospitalizations, and long-term New York Heart Association (NYHA) functional class. +other 35837763 hsa-mir-23a Myocardial Infarction, Acute 3p (HR 2.03 per 1 SD increase, P < 0.001) were able to accurately predict the primary outcome, as well as cardiovascular death, HF hospitalizations, and long-term New York Heart Association (NYHA) functional class. +other 35837763 hsa-mir-221 Heart Failure 3p (HR 2.03 per 1 SD increase, P < 0.001) were able to accurately predict the primary outcome, as well as cardiovascular death, HF hospitalizations, and long-term New York Heart Association (NYHA) functional class. +lncRNA target 35837487 hsa-mir-373 Schimke immunoosseous dysplasia 3p appears to restrict the growth and migration of HTR8 trophoblast cells by targeting SLC38A1, as observed in the placental tissues associated with smaller sIUGR fetuses, and it could have utility in the diagnosis and treatment of this disorder. +target gene 35837196 hsa-mir-383 Stomach Neoplasms Resveratrol inhibits the proliferation, invasion, and migration, and induces the apoptosis of human gastric cancer cells through the MALAT1/miR-383-5p/DDIT4 signaling pathway. +circulation_biomarker_prognosis_up 35837105 hsa-mir-374a Colonic Neoplasms Herein, we first confirmed hsa-miR-374a-3p as a tumor suppressor based on its lower expression in the plasma of patients with COAD with liver metastasis and association with more advanced local progression. +lncRNA target 35837070 hsa-mir-124 Inflammation Lnc-NEAT1 shRNA or the negative control shRNA were transfected into MMC DN cells, followed by the measurement of cell viability, apoptosis, inflammation, fibrosis and microRNA (miR)-124 expression, a known target of lnc-NEAT1, using Cell Counting Kit-8, flow cytometry, ELISA, western blotting [Capain1 (capn1), beta-catenin (CTNNB1), cleaved caspase 3, cleaved poly-(ADP ribose) polymerase, fibronectin and Collagen] and reverse transcription-quantitative PCR (Capn1, CTNNB1, lnc-NEAT1, fibronectin, collagen and miR-124), respectively. Furthermore, transfection with the miR-124 inhibitor reduced cell apoptosis but increased cell viability, inflammation and fibrosis in lnc-NEAT1-downregulated MMC DN cells. +lncRNA target 35837070 hsa-mir-124 Diabetic Nephropathies Lnc-NEAT1 shRNA or the negative control shRNA were transfected into MMC DN cells, followed by the measurement of cell viability, apoptosis, inflammation, fibrosis and microRNA (miR)-124 expression, a known target of lnc-NEAT1, using Cell Counting Kit-8, flow cytometry, ELISA, western blotting [Capain1 (capn1), beta-catenin (CTNNB1), cleaved caspase 3, cleaved poly-(ADP ribose) polymerase, fibronectin and Collagen] and reverse transcription-quantitative PCR (Capn1, CTNNB1, lnc-NEAT1, fibronectin, collagen and miR-124), respectively. Furthermore, transfection with the miR-124 inhibitor reduced cell apoptosis but increased cell viability, inflammation and fibrosis in lnc-NEAT1-downregulated MMC DN cells. +genetics_overexpression_promote 35837064 hsa-mir-146b Diabetic Nephropathies HIPK1 was validated as the direct target of miR-146b-5p and its overexpression could effectively reduce the effect of miR-146b-5p in contribution to the progression of HF. +other 35837047 hsa-mir-146a Cardiomyopathies The present study aimed to investigate the role of miR-146a-5p in isoproterenol (ISO)-induced cardiac fibrosis. Taken together, the results of the present study suggested that the miR-146a-5p/FGF2 pathway may be a novel therapy for cardiac fibrosis. +circulation_biomarker_diagnosis_ns 35837043 hsa-mir-5571 Granulomatous Mastitis 3p were confirmed to be significantly increased in the serum of patients with GLM compared with their levels in the serum of healthy volunteers, which suggests that they may be used as biomarkers of GLM. +circulation_biomarker_diagnosis_ns 35837043 hsa-mir-451a Granulomatous Mastitis 3p were confirmed to be significantly increased in the serum of patients with GLM compared with their levels in the serum of healthy volunteers, which suggests that they may be used as biomarkers of GLM. +lncRNA target 35836925 hsa-mir-192 Pulmonary Fibrosis 5p alleviates fibrosis and inflammatory responses of tendon cells by targeting NFAT5. +exosome 35836922 hsa-mir-150 Urinary Bladder Neoplasms Exosomes containing miR +other 35836907 hsa-mir-145 Angelman Syndrome This study aimed to discuss the effect of miR-145 in AS occurrence and development. +circulation_biomarker_diagnosis_up 35836862 hsa-mir-126 Vasospasm, Intracranial, Postoperative CONCLUSION: miR-126 is highly expressed in the serum of patients with intracranial aneurysm, so it may be used as a potential biomarker for the diagnosis of patients with intracranial aneurysm and the prediction of cerebral vasospasm after operation. +circulation_biomarker_diagnosis_up 35836862 hsa-mir-126 Intracranial Aneurysm CONCLUSION: miR-126 is highly expressed in the serum of patients with intracranial aneurysm, so it may be used as a potential biomarker for the diagnosis of patients with intracranial aneurysm and the prediction of cerebral vasospasm after operation. +other 35836847 hsa-mir-661 Pre-Eclampsia A lncRNA-miRNA-mRNA co-expression network analysis showed that ENST00000559730-hsa-miRNUDT16 was the most frequently associated with susceptibility-relation of PE. +target gene 35836846 hsa-mir-612 Ovarian Neoplasms miRNA-612 suppresses ovarian cancer cell tumorigenicity by downregulating NOB1. +lncRNA target 35836842 hsa-mir-362 Squamous Cell Carcinoma of Head and Neck OBJECTIVE: To investigate the mechanism of lncRNA MALAT1 (MALAT1) inhibiting the proliferation and invasiveness of laryngeal squamous cell carcinoma (LSCC) Hep-2 cells by modulating miR +lncRNA target 35836824 hsa-mir-144 Osteoporotic Fracture, Tibial The bioinformatics website and double luciferase were used to predict the targeting relationship between MALAT1 and miR +lncRNA target 35836520 hsa-mir-614 Breast Neoplasms 3p in suppressing BC metastasis. +target gene 35836485 hsa-mir-1229 Colorectal Neoplasms Circular RNA 0001666 inhibits colorectal cancer cell proliferation, invasion and stemness by inactivating the Wnt/β-catenin signaling pathway and targeting microRNA-1229. +exosome 35836229 hsa-mir-146a Pain, Inflammatory CONCLUSION: Huc-MSCs-derived exosomes attenuated inflammatory pain via miR-146a-5p/TRAF6, which increased the level of autophagy and inhibited pyroptosis. +other 35836137 hsa-mir-486 Carcinoma, Non-Small-Cell Lung 5p/RAP1-NF-kappaB axis is identified to be closely associated with the process. +lncRNA target 35836108 hsa-mir-221 Cardiomegaly CONCLUSIONS: Our findings suggest that METTL3 positively modulates the pri-miR221/222 maturation process in an m6A-dependent manner and subsequently activates Wnt/beta-catenin signaling by inhibiting DKK2, thus promoting Ang-II-induced cardiac hypertrophy. +lncRNA target 35836107 hsa-mir-145 Nasopharyngeal Carcinoma 5p could repress the proliferation, migration, and invasion of NPC cells via KLF5/FAK regulation, and could be a potential therapeutic target for patients with NPC. +other 35836014 hsa-mir-148a Hirschsprung Disease METHODS: The relative expression levels of LINC00346, miR-148a-3p and Dnmt1 in HSCR colon tissues were detected by quantitative real-time PCR. +lncRNA target 35835978 hsa-mir-21 Glioblastoma We identified a panel of five miRNAs (miRNA-138, miRNA-139, miRNA-218, miRNA-490, and miRNA-21) and their oncogenic targets (CDK6, ZEB1, STAT3, TGIF2, and SMAD7) that cover four different signaling pathways (cell proliferation and apoptotic signaling, invasion and metastasis, cytokine signaling, and stemness) in GBM. +lncRNA target 35835978 hsa-mir-139 Glioblastoma We identified a panel of five miRNAs (miRNA-138, miRNA-139, miRNA-218, miRNA-490, and miRNA-21) and their oncogenic targets (CDK6, ZEB1, STAT3, TGIF2, and SMAD7) that cover four different signaling pathways (cell proliferation and apoptotic signaling, invasion and metastasis, cytokine signaling, and stemness) in GBM. +lncRNA target 35835978 hsa-mir-490 Glioblastoma We identified a panel of five miRNAs (miRNA-138, miRNA-139, miRNA-218, miRNA-490, and miRNA-21) and their oncogenic targets (CDK6, ZEB1, STAT3, TGIF2, and SMAD7) that cover four different signaling pathways (cell proliferation and apoptotic signaling, invasion and metastasis, cytokine signaling, and stemness) in GBM. +lncRNA target 35835978 hsa-mir-218 Glioblastoma We identified a panel of five miRNAs (miRNA-138, miRNA-139, miRNA-218, miRNA-490, and miRNA-21) and their oncogenic targets (CDK6, ZEB1, STAT3, TGIF2, and SMAD7) that cover four different signaling pathways (cell proliferation and apoptotic signaling, invasion and metastasis, cytokine signaling, and stemness) in GBM. +lncRNA target 35835978 hsa-mir-138 Glioblastoma We identified a panel of five miRNAs (miRNA-138, miRNA-139, miRNA-218, miRNA-490, and miRNA-21) and their oncogenic targets (CDK6, ZEB1, STAT3, TGIF2, and SMAD7) that cover four different signaling pathways (cell proliferation and apoptotic signaling, invasion and metastasis, cytokine signaling, and stemness) in GBM. +circRNA target 35835791 hsa-mir-667 Syphilis 5p had potential targeting effects with NLRC4. +circRNA target 35835791 hsa-mir-667 Diabetic Nephropathies 5p had potential targeting effects with NLRC4. +other 35835402 hsa-mir-21 Diabetic Nephropathies 3p) were highly expressed in diabetic kidneys compared to healthy ones. +other 35835402 hsa-mir-214 Diabetic Nephropathies 3p) were highly expressed in diabetic kidneys compared to healthy ones. +other 35835402 hsa-mir-342 Diabetic Nephropathies 3p) were highly expressed in diabetic kidneys compared to healthy ones. +other 35835402 hsa-mir-146a Diabetic Nephropathies Also, miR-146a, a marker of kidney inflammation, and mRNA levels of Fn-1 and Nphs, two markers of fibrosis and inflammation, were elevated in DM. +circulation_biomarker_diagnosis_ns 35835374 hsa-mir-148 Prostatic Neoplasms Herein, we investigated whether miR-145, miR-148, and miR-185 circulating levels in plasma could be used as molecular biomarkers, to allow distinguishing between individuals with benign prostatic hyperplasia, precancerous lesions, and PC. +circulation_biomarker_diagnosis_ns 35835374 hsa-mir-185 Prostatic Neoplasms Herein, we investigated whether miR-145, miR-148, and miR-185 circulating levels in plasma could be used as molecular biomarkers, to allow distinguishing between individuals with benign prostatic hyperplasia, precancerous lesions, and PC. +circulation_biomarker_diagnosis_ns 35835374 hsa-mir-145 Prostatic Neoplasms Herein, we investigated whether miR-145, miR-148, and miR-185 circulating levels in plasma could be used as molecular biomarkers, to allow distinguishing between individuals with benign prostatic hyperplasia, precancerous lesions, and PC. +genetics_GWAS 35835333 hsa-mir-124 Leukemia, Myeloid, Acute Ectopic viral integration Site-1 oncogene promotes NRAS pathway through epigenetic silencing of microRNA-124 in acute myeloid leukemia. +other 35835254 hsa-mir-21 Nasal Polyps RESULTS: The upregulated miR5p in the nasal mucosa of patients with CRSwNP, compared with control subjects, was expressed higher in patients with ECRSwNP than in patients with nonECRSwNP. +other 35835254 hsa-mir-21 Chronic Rhinosinusitis With Nasal Polyps RESULTS: The upregulated miR5p in the nasal mucosa of patients with CRSwNP, compared with control subjects, was expressed higher in patients with ECRSwNP than in patients with nonECRSwNP. +other 35835254 hsa-mir-21 Nasopharyngitis RESULTS: The upregulated miR5p in the nasal mucosa of patients with CRSwNP, compared with control subjects, was expressed higher in patients with ECRSwNP than in patients with nonECRSwNP. +lncRNA target 35835182 hsa-mir-34a Coronary Microcirculation Dysfunction Ligustrazine exerts endothelial-protective, anti-platelet and anti-inflammatory effects to prevent CMD via suppressing miR-34a-5p and promoting Sirt1. +other 35834955 hsa-mir-214 Diabetic Nephropathies These results suggest that hyperglycemia represses miR3p by inducing lncRNA-CES1P1, which promotes the expression of the inflammatory factors IL-17, IkappaB, NF-kappaB and IL-6 ultimately leading to the development of DN. +other 35834877 hsa-mir-122 Trichohepatoenteric Syndrome 5p/OCLN signaling may be a candidate therapeutic pathway for diarrhea of piglets. +other 35834877 hsa-mir-122 Inflammation Cytometry kit 8 (CCK-8), lactate dehydrogenase (LDH), real-time quantitative polymerase chain reaction (RT-qPCR), Western blot, flow cytometry and fluorescein isothiocyanate-dextran 4 (FITC-Dextran 4) flux assays were performed to study the effect of ALDB-898 and ssc-miR5p in apoptosis, inflammation and intestinal barrier damage and inflammatory in IPEC-J2 cells induced by CPB2. +other 35834877 hsa-mir-122 Enterocolitis, Pseudomembranous There were lower expression levels of ALDB-898 and OCLN and higher expression levels of ssc-miR5p in diarrhea piglets caused by Clostridium perfringens type C. +other 35834877 hsa-mir-122 Intestinal Diseases Cytometry kit 8 (CCK-8), lactate dehydrogenase (LDH), real-time quantitative polymerase chain reaction (RT-qPCR), Western blot, flow cytometry and fluorescein isothiocyanate-dextran 4 (FITC-Dextran 4) flux assays were performed to study the effect of ALDB-898 and ssc-miR5p in apoptosis, inflammation and intestinal barrier damage and inflammatory in IPEC-J2 cells induced by CPB2. +other 35834034 hsa-mir-155 Pulpitis In this work, we discovered that the expression of miR-155 was associated with dental pulpal inflammation both in vivo and in vitro. +other 35833845 hsa-mir-26a Leukemia, Lymphocytic, Chronic, B-Cell This study evaluated the microRNAs miR-197, miR-26a and miR-27a as potential biomarkers for CLL. After adjusting for multiple logistic regression analysis, miR-197 and miR-26a remained as possible independent risk factors related to the CLL. +other 35833845 hsa-mir-197 Leukemia, Lymphocytic, Chronic, B-Cell This study evaluated the microRNAs miR-197, miR-26a and miR-27a as potential biomarkers for CLL. After adjusting for multiple logistic regression analysis, miR-197 and miR-26a remained as possible independent risk factors related to the CLL. +genetics_knock down_promote 35833822 hsa-mir-150 late onset Parkinson's disease Moreover, miR1505p overexpression suppressed ferroptosis in PD cell model. Taken together, knockdown of NEAT1 mitigated MPP+induced ferroptosis through regulating BAP1/SLC7A11 axis by sponging miR1505p, indicating the potential of NEAT1 as a promising therapeutic target for PD. +genetics_knock down_promote 35833822 hsa-mir-150 Siderosis miR1505p inhibition or BAP1 overexpression mitigated the antiferroptosis effect meditated by shNEAT1. +lncRNA target 35833819 hsa-mir-155 Reperfusion Injury This investigation aims to explore the neuroprotective role of PA in ischemia/reperfusion via miR155/NRF2/HO1 axis. +lncRNA target 35833665 hsa-mir-577 Colorectal Neoplasms Furthermore, interference with Linc00883 restrained the proliferation, invasion, and migration of CRC cells through the miR-577/FKBP14 axis. Our results demonstrated that Linc00883 facilitated the proliferation, invasion, and migration of CRC cells by regulating the miR-577/FKBP14 axis. +lncRNA target 35833537 hsa-mir-22 Heart Failure 3p and miR-29a-3p by targeting AKT serine/threonine kinase 3 (AKT3) in HSCs were explored. +other 35833537 hsa-mir-22 Cholestasis The HF model in cholestatic rats by ligating the common bile duct was induced and the differentially expressed miRNAs in the liver tissues were analyzed by microarray, which showed that miR3p and miR-29a-3p were significantly downregulated in bile-duct ligation (BDL) rat liver compared with the sham control. +other 35833537 hsa-mir-29a Cholestasis The HF model in cholestatic rats by ligating the common bile duct was induced and the differentially expressed miRNAs in the liver tissues were analyzed by microarray, which showed that miR3p and miR-29a-3p were significantly downregulated in bile-duct ligation (BDL) rat liver compared with the sham control. +lncRNA target 35833537 hsa-mir-29a Esophageal Squamous Cell Carcinoma In addition, cellular senescence was induced and the expressions of the LX-2 fibrosis markers COL1A1 and alpha-SMA were inhibited by miR +other 35833537 hsa-mir-22 De Lange Syndrome 3p and miR-29a-3p were downregulated in activated LX-2 and human primary normal hepatic fibroblasts (NFs), whereas AKT3 was found to be upregulated in BDL rat liver and activated LX-2 cells. +other 35833537 hsa-mir-29a De Lange Syndrome 3p and miR-29a-3p were downregulated in activated LX-2 and human primary normal hepatic fibroblasts (NFs), whereas AKT3 was found to be upregulated in BDL rat liver and activated LX-2 cells. +lncRNA target 35833537 hsa-mir-22 Esophageal Squamous Cell Carcinoma In addition, cellular senescence was induced and the expressions of the LX-2 fibrosis markers COL1A1 and alpha-SMA were inhibited by miR +lncRNA target 35833537 hsa-mir-29a Heart Failure 3p and miR-29a-3p by targeting AKT serine/threonine kinase 3 (AKT3) in HSCs were explored. +genetics_overexpression_promote 35833267 hsa-mir-483 Alzheimer Disease Finally, XPO1 overexpression rescued the suppressive effect of miR +transcription factor target 35833119 hsa-mir-3 Inflammation 5p to defend against MG infection by inhibiting the JNK signaling pathway. +circRNA target 35833065 hsa-mir-205 Breast Neoplasms 30, and MCF7 are cultured, and the mRNA expressions of hsa_circ_000 1429, miR-205, and KDM4A are detected by qRT-PCR; hsa_circ_000 1429 binds to miR-205, and miR-205 targets KDM4A. +circulation_biomarker_diagnosis_up 35832845 hsa-mir-6727 Stomach Neoplasms miR-4741 upregulation and miR-32, miR-3149, and miR-6727 downregulations were found in tissues and plasma of gastric cancer patients. +circulation_biomarker_diagnosis_up 35832845 hsa-mir-32 Stomach Neoplasms miR-4741 upregulation and miR-32, miR-3149, and miR-6727 downregulations were found in tissues and plasma of gastric cancer patients. +circulation_biomarker_diagnosis_up 35832845 hsa-mir-4741 Stomach Neoplasms miR-4741 upregulation and miR-32, miR-3149, and miR-6727 downregulations were found in tissues and plasma of gastric cancer patients. +circulation_biomarker_diagnosis_up 35832845 hsa-mir-149 Stomach Neoplasms miR-4741 upregulation and miR-32, miR-3149, and miR-6727 downregulations were found in tissues and plasma of gastric cancer patients. +lncRNA target 35832651 hsa-mir-125b Arthritis, Rheumatoid Taken together, our study revealed that HQT could attenuate RA through upregulating miR-125b to suppress NF-kappaB-induced inflammation by targeting CK2. +lncRNA target 35832124 hsa-mir-424 Carcinoma, Endometrioid RESULTS: 1119 differential mRNAs, 14 differential lncRNAs, and 65 differential miRNAs were screened in TCGA; we constructed a ceRNA regulatory network composed of 5 DELs, 7 DEMs, and 90 DEGs; String combined with Cytoscape to screen out Top10 hub genes, namely: LEFTY1, LIN28A, LHX3, ST8SIA3, CEP55, FBXO32, DCN, ANGPTL1, ADRA1A, and KCNMA1; the StarBase database verification results show that ADRA1A, ANGPTL1, FBXO32, KCNMA1, and DCN are downregulated in endometrial cancer tissues; LEFTY1, LIN28A, LHX3, ST8SIA3, and CEP55 are upregulated in endometrial cancer; the constructed lncRNA-miRNA-hub Top10 mRNA network map identified CTD-2314B22, RP11-89 K21/hsa-miR-143, hsa-miR-424/LEFTY1, LIN28A, LHX3, ST8SIA3, and CEP55 signal axis; survival analysis results show that CTD-2314B22, RP11-89 K21, hsa-miR-96, hsa-miR-211, LHX3, ST8SIA3, and DCN are all related to survival; RT-qPCR results indicate CTD-2314B22, RP11-89 K21, LEFTY1, LIN28A, LHX3, ST8SIA3, and CEP55 are upregulated in endometrial cancer cells, and hsa-miR-143 and hsa-miR-424 are downregulated in endometrial cancer cells. CONCLUSION: From the perspective of the lncRNA-miRNA-mRNA network, our study identified CTD-2314B22, RP11-89 K21/hsa-miR-143, hsa-miR-424/LEFTY1, LIN28A, LHX3, ST8SIA3, and CEP55 signal axis, which can present considerably potent biomarkers and therapeutic targets for treating endometrial cancer. +lncRNA target 35832124 hsa-mir-143 Carcinoma, Endometrioid RESULTS: 1119 differential mRNAs, 14 differential lncRNAs, and 65 differential miRNAs were screened in TCGA; we constructed a ceRNA regulatory network composed of 5 DELs, 7 DEMs, and 90 DEGs; String combined with Cytoscape to screen out Top10 hub genes, namely: LEFTY1, LIN28A, LHX3, ST8SIA3, CEP55, FBXO32, DCN, ANGPTL1, ADRA1A, and KCNMA1; the StarBase database verification results show that ADRA1A, ANGPTL1, FBXO32, KCNMA1, and DCN are downregulated in endometrial cancer tissues; LEFTY1, LIN28A, LHX3, ST8SIA3, and CEP55 are upregulated in endometrial cancer; the constructed lncRNA-miRNA-hub Top10 mRNA network map identified CTD-2314B22, RP11-89 K21/hsa-miR-143, hsa-miR-424/LEFTY1, LIN28A, LHX3, ST8SIA3, and CEP55 signal axis; survival analysis results show that CTD-2314B22, RP11-89 K21, hsa-miR-96, hsa-miR-211, LHX3, ST8SIA3, and DCN are all related to survival; RT-qPCR results indicate CTD-2314B22, RP11-89 K21, LEFTY1, LIN28A, LHX3, ST8SIA3, and CEP55 are upregulated in endometrial cancer cells, and hsa-miR-143 and hsa-miR-424 are downregulated in endometrial cancer cells. CONCLUSION: From the perspective of the lncRNA-miRNA-mRNA network, our study identified CTD-2314B22, RP11-89 K21/hsa-miR-143, hsa-miR-424/LEFTY1, LIN28A, LHX3, ST8SIA3, and CEP55 signal axis, which can present considerably potent biomarkers and therapeutic targets for treating endometrial cancer. +lncRNA target 35832084 hsa-mir-155 Acute Kidney Injury Conclusion: We demonstrated that miR-155 deficiency could significantly attenuate pathological damage and mortality in cAKI through inhibition of TECs apoptosis, genome instability, and telomeric dysfunction, which is possibly regulated by the increasing expression of TRF1 and CDK12. +genetics_knock down_promote 35831436 hsa-mir-1224 Osteoporosis Furthermore, knockdown of miRNA +genetics_overexpression_promote 35831436 hsa-mir-1224 Fractures, Bone In addition, in vivo overexpression of miR +transcription factor target 35831436 hsa-mir-1224 Pseudarthrosis Taken together, these results identify miR5p as a key bone osteogenic regulator, which may be a potential therapeutic target for osteoporosis and fracture nonunion. +genetics_overexpression_promote 35831436 hsa-mir-1224 Deficiency Diseases In addition, in vivo overexpression of miR5p significantly promoted fracture healing and ameliorated the progression of osteoporosis caused by estrogen deficiency or aging. +other 35831411 hsa-let-7b Sepsis Sepsis-linked decrease transcription of the classical HLA gene such as HLA-DPB1 and its interplay with miR-let-7b-5p and transcription factor SPIB was observed. +lncRNA target 35831303 hsa-mir-192 Uterine Cervical Neoplasms Further research showed that miR-192, which plays as a tumor suppressor in CC, was identified as a downstream target of RacGAP1 in CC cells. +genetics_knock down_suppress 35831154 hsa-mir-616 Angelman Syndrome 3p inhibitor stimulated cell proliferation, arrested apoptosis, and caused a decline in the levels of inflammatory factors, whereas knockdown of RFX7 abolished the effects.Circ_0030042 weakened ox-LDL-induced HUVEC injury by regulating the miR +circulation_biomarker_diagnosis_ns 35831141 hsa-mir-188 Myocardial Infarction The serum levels of lncRNA APF, MIAT, MALAT1, H19, CHAST, CDR1AS, miR +circulation_biomarker_diagnosis_ns 35831141 hsa-mir-188 Depression The serum levels of lncRNA APF, MIAT, MALAT1, H19, CHAST, CDR1AS, miR +genetics_overexpression_promote 35830966 hsa-mir-548d Lymphoma, Large B-Cell, Diffuse CONCLUSION: DLBCL patients with downregulation of hsa-miR-548d-3p and overexpression of HOXA9 mRNA are more likely to experience R-CHOP therapy resistance and disease progression. +genetics_overexpression_promote 35829849 hsa-mir-5088 Squamous Cell Carcinoma of Head and Neck Overexpression of SLC16A1-AS1 in OSCC cells resulted in inhibited maturation of miR +other 35822682 hsa-mir-155 Osteoarthritis We aimed to evaluate the effect of crocin on the gene expression of microRNA-146a, microRNA-155, microRNA-223, and microRNA-21 in OA patients and compare it with a placebo. +other 35822682 hsa-mir-223 Osteoarthritis We aimed to evaluate the effect of crocin on the gene expression of microRNA-146a, microRNA-155, microRNA-223, and microRNA-21 in OA patients and compare it with a placebo. +other 35822682 hsa-mir-146a Osteoarthritis We aimed to evaluate the effect of crocin on the gene expression of microRNA-146a, microRNA-155, microRNA-223, and microRNA-21 in OA patients and compare it with a placebo. +other 35822682 hsa-mir-21 Osteoarthritis We aimed to evaluate the effect of crocin on the gene expression of microRNA-146a, microRNA-155, microRNA-223, and microRNA-21 in OA patients and compare it with a placebo. +other 35822676 hsa-mir-200c COVID-19 Since ACE2 reduces the acute inflammatory effects in lung diseases and acts as a coronavirus receptor to invade the lung cells, this study investigates the relationship between miR-200c-3p and ACE2 expression in COVID -19 patients. +exosome 35822640 hsa-mir-378a Wounds and Injuries Conclusion: Exosomal MALAT1 accelerated skin wound healing by regulating the miR-378a/FGF2 axis, suggesting that MALAT1 might be used as a potential target for cutaneous wound treatment. +other 35821682 hsa-mir-26b Prostatic Neoplasms The receiver operating characteristic curve and cell line qRT-PCR experiments demonstrated the power of miR-26b-5p, miR-130a-3p, and miR3p as novel candidates for predicting PCa metastasis. +other 35821682 hsa-mir-130a Prostatic Neoplasms The receiver operating characteristic curve and cell line qRT-PCR experiments demonstrated the power of miR-26b-5p, miR-130a-3p, and miR3p as novel candidates for predicting PCa metastasis. +genetics_overexpression_promote 35821222 hsa-mir-146a Stomach Neoplasms The promotion of GC cell proliferation, migration and invasion mediated by LSECtin was largely inhibited by circFBXL4 overexpression or miR-146a-5p silencing. In conclusion, LSECtin might be involved in the lymphatic metastasis of GC by upregulating the expression of FN1 and CHD4 via the circFBXL4/miR-146a-5p/STAT1 axis, possibly indicating a newly discovered pathogenic mechanism. +other 35821197 hsa-mir-21 Breast Neoplasms MiR-21 was identified as a gene whose expression correlated with the extent of metastasis of murine mammary tumours. Since miR-21 is recognised as being associated with poor prognosis in cancer, we investigated its contribution to mammary tumour growth and metastasis in tumours with capacity for spontaneous metastasis. +lncRNA target 35821145 hsa-mir-22 Alzheimer Disease 3p ameliorated AD by targeting Sox9 through the NF-kappaB signaling pathway in the hippocampus. +exosome 35821021 hsa-mir-139 Urinary Bladder Neoplasms 5p in bone marrow mesenchymal stem The emerging roles of extracellular vesicles (EVs) in bladder cancer have recently been identified. +lncRNA target 35821018 hsa-mir-143 Reperfusion Injury Mechanistically, mmu_circ_0000021 involved in regulating microvascular dysfunction via miR3p by targeting NPY. +other 35820565 hsa-mir-145 Diabetes Mellitus, Type 1 5p and albuminuria that was mediated by systemic hypertension. +lncRNA target 35819589 hsa-mir-507 Stomach Neoplasms MiR-507 has been confirmed as a tumor inhibitor which can suppress the progression of multiple cancers while its role in GC remains unknown. +lncRNA target 35819551 hsa-mir-195 Stomach Neoplasms The downregulated SNHG1 hinders the biological behaviors of GC cells via the modulation of the miR +other 35819446 hsa-mir-146b Leukemia, Lymphocytic, Chronic, B-Cell MiR-146b-5p regulates IL-23 receptor complex expression in chronic lymphocytic leukemia cells. +lncRNA target 35818964 hsa-mir-654 Stomach Neoplasms Together, this study showed that circ_0067514 suppressed gastric cancer aggressive development and glycolysis via miR +other 35818915 hsa-mir-487a Carcinoma, Renal Cell CONCLUSION: The enhanced expression of miR-487a was related to the prognosis of ccRCC, and it also facilitated cell proliferation, migration, and invasion. +other 35818817 hsa-mir-24 Pre-Eclampsia 3p in regulating RBP4 during trophoblast dysfunction and PE development. +genetics_knock down_promote 35818779 hsa-mir-497 Colorectal Neoplasms 5p overexpression suppressed CRC cell growth, invasion and glutamine metabolism, and SLC7A5 was able to revoke this effect. +transcription factor target 35818586 hsa-mir-127 Meningioma CONCLUSION: miR5p regulated meningioma formation and ferroptosis through JAM3, providing insights for the development of new treatments for meningioma. +other 35818274 hsa-mir-27b Tuberculosis tuberculosis-infected macrophages, the expression level of BAG2 decreased from (284.24+/-6.31) to (156.48.24+/-4.49), and the expression level of miR-27b was increased from (43.72+/-3.35) to (78.35+/- 4.17), the apoptosis rate increased by 17.8%, and the autophagy rate increased by 20.6%. +lncRNA target 35818268 hsa-mir-494 Uterine Cervical Neoplasms The purpose of this article is to further explore the effectiveness of miR-494 in inhibiting the proliferation, migration and invasion of CC cells by regulating LETMD1, selecting 40 cases of CC admitted to a hospital from June 2015 to September 2018 Patients, tumor tissue specimens were taken from the primary tumor tissue of CC, and normal tissues near the cutting edge were collected as controls. After high expression of miR-494 in CC patients, the vascular invasion of CC cells was reduced by 33%, and distant metastasis was reduced by 11%, and the survival time of patients was significantly prolonged. +lncRNA target 35818262 hsa-mir-182 Bone Diseases The results showed that protein expression levels of RANKL, OPG and CXCL10 in the miR-182 group were significantly higher than those in other groups (P>0.01). In general, miR-182 alleviates OP by inhibiting the activity of osteoclast via RANKL/NFkappaB signaling. +transcription factor target 35818261 hsa-mir-494 Uterine Cervical Neoplasms This study focused on miR-494 inhibiting the proliferation, migration and invasion of cervical cancer cells by regulating HCCR1. The qRT-PCR results showed that compared with the normal cervical tissue cell line HCCR1, the expression levels of miR-494 in cervical cancer cell lines HCCR1 and C-33A were significantly reduced. +transcription factor target 35818253 hsa-mir-129 Colonic Neoplasms 5p had a more substantial effect on the proliferation and apoptosis of CC by targeting RSF1. +lncRNA target 35818245 hsa-mir-143 Breast Neoplasms 3p can increase the radiosensitivity of breast cancer cells through FGF1. +circulation_biomarker_diagnosis_up 35818240 hsa-mir-145 Thyroid Cancer, Papillary In general, the expression of miRNA-22l in serum of PTC patients is significantly up-regulated, while the expression level of miR-145 is down-regulated, which can be used as effective indicators to judge the biological activity of the tumor, and the combined detection of the two can significantly enhance the diagnostic value of PTC. Upregulation of miR-145 inhibits PTC cell proliferation; arrests cell cycle and promotes apoptosis miR-145 may play an important role as a tumor suppressor gene. +other 35818240 hsa-mir-221 Thyroid Cancer, Papillary This study aimed to investigate the expression of miR-221 and miR-145 in papillary thyroid carcinoma, and the effect of miR-221 and miR-145 on the invasion ability of thyroid cancer cells and its mechanism. +circulation_biomarker_prognosis_up 35818236 hsa-mir-27a Heart Failure The difference of miR-27a expression level in serum exosomes between the two groups of subjects was compared, so as to analyze the diagnostic value of miR-27a in CHF and the relationship between miR-27a expression level and patient prognosis. +lncRNA target 35818227 hsa-mir-124 Sepsis The results showed that AKT1, MMP9, ARG1, ETS1 targeting AKT1, and has-miR3p targeting RPS6KA5 may have diagnostic value for patients with sepsis and septic shock. +other 35818213 hsa-mir-144 Glioma The expressions of Mir-HCG11, Mir3p and COX-2 in each group were observed, and the proliferation and apoptosis of glioma cells were analyzed, and their drug resistance was analyzed. +other 35818205 hsa-mir-135a Hepatoblastoma In this experiment, we used in vitro culture of hepatoblastoma cells and flow cytometry to detect the effect of miRNA-135a on the tumor cell cycle. +circulation_biomarker_diagnosis_ns 35818203 hsa-mir-145 Ovarian Neoplasms The miR-145 recombinant plasmid and the empty plasmid into OC cells were transfected, and qRT-PCR was used to detect the expression of miR-145 in the transfected OC cells. +other 35818196 hsa-mir-513b Lung Neoplasms The expressions of circ_UHRF1 and miR-513b-5p in lung cancer tissues were negatively correlated (r=-0.861, P<0.05). +target gene 35818076 hsa-mir-3173 Prostatic Neoplasms LINC00893 inhibits the progression of prostate cancer through miR-3173-5p/SOCS3/JAK2/STAT3 pathway. +lncRNA target 35818041 hsa-mir-199a Adenocarcinoma, Follicular In addition, we found that PD-L1 expression was positively correlated with Claudin-1 expression and that miR-199a-5p affected the progression of FTC cells through the negative regulation of PD-L1 and Claudin-1. +circulation_biomarker_diagnosis_up 35817886 hsa-mir-671 Atherosclerosis 5p expression was decreased in the serum of patients with AS and in ox-LDL-treated HUVECs. +exosome 35817771 hsa-mir-370 Glioma Our results demonstrate for the first time that exosome-mediated delivery of circWDR62 can promote TMZ resistance and malignant progression via targeting of the miR +lncRNA target 35817571 hsa-mir-155 Lupus Erythematosus, Systemic In addition, we identified PSMB10, PSMB4, TAF10, NFKappaBIA and miR-155 involved in the common pathogenesis as potential biomarkers and therapeutic targets for DLBCL. +lncRNA target 35817571 hsa-mir-155 Lymphoma, Large B-Cell, Diffuse In addition, we identified PSMB10, PSMB4, TAF10, NFKappaBIA and miR-155 involved in the common pathogenesis as potential biomarkers and therapeutic targets for DLBCL. +genetics_knock down_suppress 35817473 hsa-mir-29a Uterine Cervical Neoplasms CONCLUSION: In this research, knockdown of HOXA-AS3 could alleviate the process of cervical cancer by sponging miR-29a-3p, suggesting that HOXA-AS3 may be a potential prognostic target of cervical cancer, which could provide a theoretical basis for future clinical research of cervical cancer. +lncRNA target 35817112 hsa-mir-137 Prostatic Neoplasms These findings suggest that endosulfan can indeed promote cell migration and invasion via the KCNQ1OT1/miR3p/PTP4A3 axis in PCa cells. +exosome 35816980 hsa-mir-29 Skeletal Muscle Injury Here, a silk sericin patch delivering miRNAenriched extracellular vesicles-decorated myoblasts (SPEED) is designed for the rapid regeneration and functional repair after severe skeletal muscle injury. +other 35816613 hsa-mir-889 Carcinoma, Hepatocellular 5p/KLF9 axis for HCC progression, and we postulate that blocking this key signaling pathway may represent a promising strategy for HCC treatment. +other 35816558 hsa-mir-326 Carcinoma, Hepatocellular CONCLUSIONS: E2F1-activated SNHG1 modulates the miR-326/PKM2 axis to facilitate glycolysis and the proliferation of HCC cells. +lncRNA target 35816228 hsa-mir-627 Colonic Neoplasms 5p suppressed colon cancer growth. +lncRNA target 35815670 hsa-mir-17 Arthritis, Rheumatoid 5p and inhibiting STAT3. +other 35815280 hsa-mir-491 Stomach Neoplasms 3p expression was found in gastric cancer, being a high diagnostic efficiency and an independent risk factor for gastric cancer, especially in those having LNM. +circulation_biomarker_diagnosis_up 35814945 hsa-mir-21 Coronary Artery Disease The expressions of plasma mir-21 were evidently and progressively higher while PDCD4 levels were significantly and steadily lower in single-, dual-, and multivessel occluded CAD patients than in healthy participants (P < 0.001). +transcription factor target 35814901 hsa-mir-451 Retinal Neovascularization miRNA-451 can be a protective factor for neovascular disease of fundus via regulating choroid retinal endothelial cell function. +other 35814832 hsa-mir-486 Colonic Neoplasms On the whole, the findings of the present study suggest that PVT1 promotes the resistance of colon cancer cells to 5-FU by regulating the miR5p/CDK4 axis. +lncRNA target 35814830 hsa-mir-1827 Prostatic Neoplasms Notably, lncRNA SNHG3 promoted PCa progression through miR-1827 via the Wnt/AKT/mTOR pathway. +other 35814566 hsa-mir-675 Stomach Neoplasms 3p. +target gene 35814430 hsa-mir-658 Stomach Neoplasms Glaucocalyxin A Inhibits the Malignancies of Gastric Cancer Cells by Downregulating MDM2 and RNF6 via MiR-3658 and the SMG1-UPF mRNA Decay Pathway. +lncRNA target 35814429 hsa-mir-378a Colorectal Neoplasms Silencing of miR-378a-3p targets, MALAT1 and NEAT1, significantly impairs tumorigenic properties of CRC-SCs, supporting the critical role of miR-378a-3p in CRC carcinogenesis as a tumor-suppressor factor by establishing a finely tuned crosstalk with lncRNAs MALAT1 and NEAT1. +exosome 35814269 hsa-mir-224 Colorectal Neoplasms CONCLUSION: These findings suggested that SW620 cell-derived exosomal miR +exosome 35814268 hsa-mir-431 Intervertebral Disc Degeneration Collectively, BMSC-EV-loaded circ_0072464 inhibited NPC ferroptosis to relieve IDD via upregulation of miR +transcription factor target 35814248 hsa-mir-96 Brain Injuries, Traumatic 5p, and up-expression of inflammatory cytokines, which were all inhibited by miR +target gene 35813866 hsa-mir-1178 Stomach Neoplasms Circ_0110940 Exerts an Antiapoptotic and Pro-Proliferative Effect in Gastric Cancer Cells via the miR-1178-3p/SLC38A6 Axis. +tissue_expression_ns 35813630 hsa-mir-335 Dwarfism, Pituitary 3p changed after 3 months of GH treatment and likely reflected both the degree of GH deficiency and the sensitivity to treatment. +tissue_expression_ns 35813630 hsa-mir-199a Dwarfism, Pituitary 3p changed after 3 months of GH treatment and likely reflected both the degree of GH deficiency and the sensitivity to treatment. +tissue_expression_ns 35813630 hsa-mir-494 Dwarfism, Pituitary 3p changed after 3 months of GH treatment and likely reflected both the degree of GH deficiency and the sensitivity to treatment. +other 35813482 hsa-mir-584 Squamous Cell Carcinoma of Head and Neck Mechanistically, miR5p downregulation may lead to the upregulation of SQLE in HNSCC. +other 35813473 hsa-mir-340 Pancreatic Carcinoma 3p/HTR1D ceRNA axis acted a crucial part in the malignant biological behavior of pancreatic cancer in an AKT-dependent manner. +circulation_biomarker_diagnosis_up 35813421 hsa-mir-124 Depression 3p asponge lentiviral suspension was given to determine the weight of rats and open-field test, sugar preference experiment, Serum CORT, 5-HT, DA, and NE were measured, observe and record the behavior of rats, including behavior, diet, and hair. +other 35813414 hsa-mir-139 Gout CONCLUSION: Characterization of ceRNA networks could be a promising approach for better understanding the pathogenesis of gout, with the TTTY10/hsa-miR5p/AP-1 axis likely to be of clinical significance. +lncRNA target 35813344 hsa-mir-187 Hemangioma miR3p has previously been confirmed to promote or inhibit various malignancies, but its role in the development and progression of IH remains unclear. +other 35812757 hsa-mir-195 Breast Neoplasms Moreover, five potential upstream miRNAs (let-7b-5p, miR5p, miR-29a-3p, miR-26a-5p, and miR-26b-5p) of m(5)C regulators could not only serve as independent prognostic predictors but also together made up a promising miRNA prognostic signature in breast cancer. +other 35812757 hsa-mir-26b Breast Neoplasms Moreover, five potential upstream miRNAs (let-7b-5p, miR5p, miR-29a-3p, miR-26a-5p, and miR-26b-5p) of m(5)C regulators could not only serve as independent prognostic predictors but also together made up a promising miRNA prognostic signature in breast cancer. +other 35812757 hsa-mir-26a Breast Neoplasms Moreover, five potential upstream miRNAs (let-7b-5p, miR5p, miR-29a-3p, miR-26a-5p, and miR-26b-5p) of m(5)C regulators could not only serve as independent prognostic predictors but also together made up a promising miRNA prognostic signature in breast cancer. +other 35812757 hsa-let-7b Breast Neoplasms Moreover, five potential upstream miRNAs (let-7b-5p, miR5p, miR-29a-3p, miR-26a-5p, and miR-26b-5p) of m(5)C regulators could not only serve as independent prognostic predictors but also together made up a promising miRNA prognostic signature in breast cancer. +lncRNA target 35812732 hsa-mir-223 Papillomavirus Infections 5p), of which 11 were identified to be in HPV16-IS and targeting TP53 and RB1 genes. +lncRNA target 35812732 hsa-mir-16 Papillomavirus Infections 5p), of which 11 were identified to be in HPV16-IS and targeting TP53 and RB1 genes. +lncRNA target 35812732 hsa-mir-15b Papillomavirus Infections 5p), of which 11 were identified to be in HPV16-IS and targeting TP53 and RB1 genes. +lncRNA target 35812732 hsa-mir-200c Papillomavirus Infections 5p), of which 11 were identified to be in HPV16-IS and targeting TP53 and RB1 genes. +lncRNA target 35812732 hsa-mir-130a Papillomavirus Infections 5p), of which 11 were identified to be in HPV16-IS and targeting TP53 and RB1 genes. +lncRNA target 35812732 hsa-mir-142 Papillomavirus Infections 5p), of which 11 were identified to be in HPV16-IS and targeting TP53 and RB1 genes. +circulation_biomarker_diagnosis_ns 35812667 hsa-mir-199a Colorectal Neoplasms Further validation in an independent cohort revealed that both circulating miR5p and miR-199a-5p were sequentially increased from HCs and AAs to CRCs. +circulation_biomarker_diagnosis_up 35812667 hsa-mir-627 Colorectal Neoplasms 5p were markedly increased in patients with colorectal neoplasms and showed strong potential as minimally invasive biomarkers for the early screening of colorectal neoplasms. +transcription factor target 35812439 hsa-mir-513a Carcinoma, Hepatocellular Results of the cell counting kit 8 (CCK8), 5-ethynyl-2'-deoxyuridine (EdU), transwell, wound healing test, and flow cytometry showed that GUSB facilitated proliferation, invasion, as well as migration of human HCC cells and downregulated PD-L1 expression by promoting miR-513a-5p. In summary, this study reveals that increased GUSB downregulates PD-L1 expression by promoting miR-513a-5p, leading to primary resistance to anti-PD1 treatment in HCC, and amoxapine enhances the sensitivity of anti-PD1 therapy by inhibiting GUSB, providing a new strategy and method for improving the efficacy of anti-PD1 therapy and bringing new prospects for therapy of HCC. +other 35812382 hsa-mir-372 Cholestasis, Intrahepatic Further evidence suggested that the expression of immune-related genes KLRD1, BRAF, and NFATC4 might have a potential ceRNA mechanism by individual lncRNA sponging miR372-3p, miR-371a-3p, miR3p, and miR-449a to control downstream the level of TNF-alpha, IFN-gamma, and IL-10, thereby regulating the pathophysiology of ICP. +lncRNA target 35812178 hsa-mir-21 Pancreatic Carcinoma In the present study miR-21 was characterized and its upstream regulatory mechanism was investigated, as well as its functional effects and target genes in pancreatic ductal adenocarcinoma (PDAC). +lncRNA target 35812136 hsa-mir-195 Bone Diseases CONCLUSION: These results demonstrate that CORM-3 promoted osteogenic differentiation of rat BMSCs via miR5p/Wnt3a, which bodes well for the application of CORM-3 in the treatment of periodontal disease and other bone-defect diseases. +lncRNA target 35812136 hsa-mir-195 Periodontal Diseases CONCLUSION: These results demonstrate that CORM-3 promoted osteogenic differentiation of rat BMSCs via miR5p/Wnt3a, which bodes well for the application of CORM-3 in the treatment of periodontal disease and other bone-defect diseases. +genetics_overexpression_promote 35812061 hsa-mir-1200 Osteosarcoma Moreover, miR-1200 overexpression significantly alleviated the inhibitory effect of circNRIP1 on OS cells. +other 35812058 hsa-mir-133b Prostatic Neoplasms In conclusion, the ceRNA network of lncHUPC1/miR-133b/SDCCAG3 affected the growth and apoptosis of PCa cells, and FOXA1 may be involved in the process as a transcription factor of lncHUPC1. +other 35812044 hsa-mir-1179 Triple Negative Breast Neoplasms CircUBR5 acts as a ceRNA for miR-1179 to up-regulate UBR5 and to promote malignancy of triple-negative breast cancer. +transcription factor target 35811894 hsa-mir-603 Hypertension 5p were identified as hypertension-associated miRNA targets for each gene using computational algorithms. +transcription factor target 35811894 hsa-mir-923 Hypertension 5p were identified as hypertension-associated miRNA targets for each gene using computational algorithms. +transcription factor target 35811894 hsa-mir-2052 Hypertension 5p were identified as hypertension-associated miRNA targets for each gene using computational algorithms. +transcription factor target 35811894 hsa-mir-365a Hypertension 5p were identified as hypertension-associated miRNA targets for each gene using computational algorithms. +transcription factor target 35811894 hsa-mir-7113 Hypertension 5p were identified as hypertension-associated miRNA targets for each gene using computational algorithms. +transcription factor target 35811894 hsa-mir-3065 Hypertension 5p were identified as hypertension-associated miRNA targets for each gene using computational algorithms. +transcription factor target 35811845 hsa-mir-204 Neuroblastoma Our study demonstrates that TTF1 reduces tumor growth and induces neurogenic differentiation in NB by directly targeting TrkA and the miR-204/TrkB axis. +genetics_overexpression_promote 35811549 hsa-mir-99b Prostatic Neoplasms In PCa cell lines, overexpression of miR-99b inhibited cell proliferation and cell colony/spheroid formation; induced apoptosis, and increased sensitivity towards docetaxel (DTX). +circulation_biomarker_diagnosis_up 35811521 hsa-mir-150 Alzheimer Disease 5p is a promising clinical blood-based biomarker for DAT. +lncRNA target 35810770 hsa-mir-23b Cataract, Age-Related Circ_0060,144 and HIPK3 mRNA expression were decreased in ARC tissues, and miR-23b-3p was increased. Circ_0060,144 promoted ARC development via regulation of miR-23b-3p/HIPK3 axis. +lncRNA target 35810742 hsa-mir-181a Small Cell Lung Carcinoma CONCLUSION: Our data emphasized the anti-inflammatory actions of miR-181a by targeting TNF-alpha in the context of renal inflammation in DN. +lncRNA target 35810742 hsa-mir-181a Diabetic Nephropathies CONCLUSION: Our data emphasized the anti-inflammatory actions of miR-181a by targeting TNF-alpha in the context of renal inflammation in DN. +lncRNA target 35810709 hsa-mir-101 Rhabdomyosarcoma 1 In conclusion, our results revealed that LINC01347 suppresses the migratory ability and regulates the EMT processes in trophoblasts by regulating miR3p/PTEN/AKT axis, suggesting that targeting LINC01347 may serve as a strategy to ameliorate RM. +lncRNA target 35810663 hsa-mir-29b Acute Lung Injury CONCLUSION: Our results reveal that WIN inhibits macrophage glycolysis through the miR-29b-3p/ FOXO3/PFKFB3 axis, suggesting new therapeutic targets to alleviate sepsis-related ALI. +lncRNA target 35810662 hsa-mir-27b Pulmonary Arterial Hypertension In addition, in MCT-induced PAH rats, targeting ETAR/miR-27b-3p/FBXW7/KLF5/GLI1 pathway effectively prevented the pulmonary vascular remodeling and the development of PAH in rats. Our study indicates that interfering ETAR/miR-27b-3p/FBXW7/KLF5/GLI1 signaling axis might have a potential value in the prevention and treatment of PAH. +lncRNA target 35809813 hsa-mir-340 Pre-Eclampsia Upregulation of lncRNA XIST exerted the inhibitory effects on the proliferation and invasion of trophoblast cells through the interactions with miR +genetics_knock down_suppress 35809451 hsa-mir-335 Bronchopulmonary Dysplasia RESULTS: Firstly, SNHG6 was highly expressed and miR-335 was lowly expressed in BPD model, SNHG6 knockdown and miR-335 mimics both alleviated hyperoxia-induced lung cell injury, and SNHG6 targeted miR-335. +genetics_knock down_suppress 35809451 hsa-mir-335 Hyperoxia-Induced Lung Injury RESULTS: Firstly, SNHG6 was highly expressed and miR-335 was lowly expressed in BPD model, SNHG6 knockdown and miR-335 mimics both alleviated hyperoxia-induced lung cell injury, and SNHG6 targeted miR-335. +other 35809377 hsa-mir-460a Branchio-Oto-Renal Syndrome The present study explored the molecular mechanism of CGA on chondrocytes' apoptosis with B-cell lymphoma 2 signaling under the effect of miR-460a. RESULTS: The CGA decreased the apoptosis rate with the deactivation of miR-460a, accompanied by the activation of Bcl-2. +circulation_biomarker_diagnosis_ns 35809332 hsa-mir-214 Carcinoma, Hepatocellular MTT, cell cycle and construct recombinant plasmids analysis were used to explore the effects of miR-214 and PTK2b/Pyk2 on liver cancer cell proliferation. +other 35809331 hsa-mir-146a Lumbar Disc Herniation Then upregulation of miR-146a could reduce the activity of the TLR4 signaling pathway and the release of pro-inflammatory factors, which may be a potential strategy for the treatment of lumbar disc herniation. +circulation_biomarker_diagnosis_up 35809326 hsa-mir-1 Hypertension 3p expression and low serum BDNF levels in patients with primary hypertension complicated with depression. +circulation_biomarker_diagnosis_up 35809326 hsa-mir-1 Depression 3p expression and low serum BDNF levels in patients with primary hypertension complicated with depression. +genetics_overexpression_suppress 35809318 hsa-mir-140 Osteosarcoma Collectively, overexpression of miR-140 may inhibit human OS cell proliferation and may enhance drug sensitivity by direct regulation of Wnt/beta-catenin signaling. +genetics_overexpression_promote 35809317 hsa-mir-145 Myocardial Reperfusion Injury Overexpression of miR5p can downregulate the expression of GIGYF1, further promote cell proliferation, inhibit cell apoptosis, alleviate inflammation and oxidative stress, and hence exert a protective role in myocardial infarction IRI. +lncRNA target 35809316 hsa-mir-19b Osteoporosis It was concluded the inhibition of miR-19b-3p has a suppressive effect on the development of OP and the function of miR-19b-3p in OP is likely to be achieved by regulating the expression of the IGF-1 gene. +genetics_GWAS 35809314 hsa-mir-191 Breast Neoplasms Furthermore, NextSeq 500 revealed that a single nucleotide polymorphism (C>T) newly occurred in the mature sequence of miR5p seed region in BRCA samples. +other 35809313 hsa-mir-1 Colorectal Neoplasms In general, miR -34a-3p, miR -31, and PLEK2 are closely associated with the occurrence and development of colorectal cancer, and they are all influential factors affecting the prognosis of patients with colorectal cancer, which can provide a basis for the evaluation and treatment of patients, and are worthy of widespread clinical application. +other 35809313 hsa-mir-34a Colorectal Neoplasms The expressions of miR -34a-3p, miR -31, and PLEK2 in colon cancer tissues and normal cancer tissues were compared, and the correlation between miR -34a-3p, miR -31, and PLEK2 and clinic-pathological characteristics of colorectal cancer patients were analyzed. +circulation_biomarker_diagnosis_up 35809311 hsa-mir-145 Pre-Eclampsia Conclusion: the serum level of Gas6 was reduced in patients with early-onset preeclampsia, and TNF-a inhibited the invasion of SVneo cells by upregulating mir +tissue_expression_ns 35809289 hsa-mir-21 Abortion, Spontaneous Therefore, the present study evaluated the effect of post-abortion care (PAC) on anxiety in women with spontaneous abortion based on MicroRNA-21 expression, cortisol level, and Fordyce happiness pattern. +tissue_expression_ns 35809289 hsa-mir-21 Anxiety Disorders Therefore, the present study evaluated the effect of post-abortion care (PAC) on anxiety in women with spontaneous abortion based on MicroRNA-21 expression, cortisol level, and Fordyce happiness pattern. +other 35809285 hsa-mir-155 Diabetes Mellitus It is concluded that PPARgamma, Abeta1-42, miR-155 are closely related to the occurrence and development of diabetes, and there are many influencing factors of diabetes. +lncRNA target 35808943 hsa-mir-144 Ovarian Neoplasms 3p inhibitor notably decreased autophagy. +lncRNA target 35807865 hsa-mir-21 Colitis Taken together, our results revealed that GTP inhibits DSS-induced colonic inflammation by suppressing miR-21 expression and NF-kappaB activity, suggesting that it may be used as a potential functional material for improving colitis. +other 35807864 hsa-mir-21 Hypertension In conclusion, hypovitaminosis D correction ameliorated the cardiovascular risk profiles in hypertensive patients treated with cholecalciferol but did not influence the miR-21 expression. +other 35807767 hsa-mir-145 Uremia Vitamin D treatment from week 8 to 14 fully prevented the reductions in aortic miR-145 and attenuated by 50% the decreases in alpha-actin, despite uremia-induced hyperphosphatemia. In conclusion, vitamin D was able to prevent the reductions in aortic miR-145 and alpha-actin content induced by uremia, reducing the alterations in vascular contractility and osteogenic differentiation despite hyperphosphatemia. +other 35807767 hsa-mir-145 Hyperphosphatemia Vitamin D treatment from week 8 to 14 fully prevented the reductions in aortic miR-145 and attenuated by 50% the decreases in alpha-actin, despite uremia-induced hyperphosphatemia. In conclusion, vitamin D was able to prevent the reductions in aortic miR-145 and alpha-actin content induced by uremia, reducing the alterations in vascular contractility and osteogenic differentiation despite hyperphosphatemia. +genetics_GWAS 35807118 hsa-mir-125a Abortion, Habitual A total of 150 women that had experienced two or more RPLs and 180 healthy controls (two or more full-term pregnancies) were recruited, along with 50 product of conception (POC) samples from the corresponding RPL patients, and evaluated for miR-125a SNPs by the polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP), which was confirmed by high resolution melting (HRM)/DNA sequencing. +other 35806488 hsa-mir-17 Head and Neck Neoplasms 3p could interfere in VEGFA, KRAS, and NFE2L2 expression in cell lines derived from head and neck cancer (HNC). +other 35806488 hsa-mir-140 Head and Neck Neoplasms 3p could interfere in VEGFA, KRAS, and NFE2L2 expression in cell lines derived from head and neck cancer (HNC). +other 35806488 hsa-mir-874 Head and Neck Neoplasms 3p could interfere in VEGFA, KRAS, and NFE2L2 expression in cell lines derived from head and neck cancer (HNC). +transcription factor target 35806291 hsa-mir-497 Lung Neoplasms We also demonstrated that SREBP-1/SCAP/FASN lipogenic signaling plays a key role in CSCs-like and chemoresistant NSCLC phenotypes, especially because the fatostatin or shRNA targeting of SREBP-1 significantly suppressed the viability, cisplatin resistance, and cancer stemness of NSCLC cells and because treatment induced the expression of hsa-miR-497. CONCLUSION: Targeting the SREBP-1/hsa-miR-497 signaling axis is a potentially effective anticancer therapeutic strategy for NSCLC. +exosome 35806142 hsa-mir-203a Carcinoma, Non-Small-Cell Lung In conclusion, pulmonary TDV EV-miR-203a-3p is a promising new relapse biomarker for resected NSCLC patients. +exosome 35806142 hsa-mir-203a Small Cell Lung Carcinoma In conclusion, pulmonary TDV EV-miR-203a-3p is a promising new relapse biomarker for resected NSCLC patients. +other 35806139 hsa-mir-574 Prostatic Neoplasms, Castration-Resistant 5p) could be used as potential biomarkers for the prognosis of CRPC. +other 35806139 hsa-mir-21 Prostatic Neoplasms, Castration-Resistant 5p) could be used as potential biomarkers for the prognosis of CRPC. +transcription factor target 35805966 hsa-mir-1183 Tachycardia In sum, although stretch and tachycardia show distinct transcriptomic signatures in human atrial myocardium, both cardiac insults consistently regulate the expression of miR-1183 and its downstream targets in acute and chronic remodeling. Thus, elevated expression of miR-1183 might serve as a tissue biomarker for atrial remodeling and might be of potential functional significance in cardiac disease. +other 35805964 hsa-mir-204 Alzheimer Disease By combining different in vitro model systems of DA differentiation, we show that the levels of Lmx1a influence the expression of miR-204/211. We further demonstrated that miR-204/211 controls the timing of the DA differentiation by directly downregulating the expression of Nurr1, a late DA differentiation master gene. +lncRNA target 35805891 hsa-mir-181a Brain Injury, Ischemic Of interest, miR-181a mimicking administration in the absence of nicotine exposure also produced dose-dependent increased hypoxia/ischemia (H/I)-induced brain injury associated with a decreased ATG5 expression, closely resembling perinatal nicotine exposure-mediated effects. In conclusion, the present findings provide a novel mechanism that aberrant alteration of the H19/miR-181a/AGT5 axis plays a vital role in perinatal nicotine exposure-mediated ischemia-sensitive phenotype in offspring and suggests promising molecular targets for intervention and rescuing nicotine-induced adverse programming effects in offspring. +genetics_knock down_promote 35805200 hsa-mir-9 Carcinoma, Hepatocellular Gain- and loss-of-function studies demonstrated that miR +lncRNA target 35805086 hsa-mir-146b Ataxia Neuropathy Spectrum The miR-146 family consists of two microRNAs (miRNAs), miR-146a and miR-146b, which are both known to suppress a variety of immune responses. +other 35805015 hsa-mir-137 Stomach Neoplasms COL5A1 Promotes the Progression of Gastric Cancer by Acting as a ceRNA of miR-137-3p to Upregulate FSTL1 Expression. +genetics_overexpression_promote 35804897 hsa-mir-134 Nasopharyngeal Carcinoma Lastly, using an in vivo lung metastasis assay, we showed that ICG-001 transient overexpression of miR-134 or stable overexpression of miR-134 could significantly reduce the lung metastasis of NPC cells. +other 35804809 hsa-mir-224 Carcinoma, Hepatocellular These preliminary data show that the novel miRNAs panel (miR-150, miR-199a, miR-224, miR-424, and miR-3607) could serve as a potential non-invasive biomarker for HCC early prediction in chronic HCV patients. +other 35804809 hsa-mir-607 Carcinoma, Hepatocellular These preliminary data show that the novel miRNAs panel (miR-150, miR-199a, miR-224, miR-424, and miR-3607) could serve as a potential non-invasive biomarker for HCC early prediction in chronic HCV patients. +other 35804809 hsa-mir-424 Carcinoma, Hepatocellular These preliminary data show that the novel miRNAs panel (miR-150, miR-199a, miR-224, miR-424, and miR-3607) could serve as a potential non-invasive biomarker for HCC early prediction in chronic HCV patients. +other 35804809 hsa-mir-150 Carcinoma, Hepatocellular These preliminary data show that the novel miRNAs panel (miR-150, miR-199a, miR-224, miR-424, and miR-3607) could serve as a potential non-invasive biomarker for HCC early prediction in chronic HCV patients. +other 35804809 hsa-mir-199a Carcinoma, Hepatocellular These preliminary data show that the novel miRNAs panel (miR-150, miR-199a, miR-224, miR-424, and miR-3607) could serve as a potential non-invasive biomarker for HCC early prediction in chronic HCV patients. +genetics_knock down_suppress 35804263 hsa-mir-431 Thyroid Neoplasms 5p downregulation reversed the role of circRTN1 knockdown in TC cells. +genetics_overexpression_promote 35803492 hsa-mir-93 Hypoxia-Ischemia, Brain Importantly, MSC-derived EVs overexpressing miR-93 suppressed HDAC4 expression and subsequently impeded the apoptosis of OGD-exposed hippocampal neurons in vitro, and also ameliorated HIBD in vivo. Taken together, miR-93 delivered by MSC-derived EVs can ameliorate HIBD by suppressing hippocampal neuron apoptosis through targeting the HDAC4/Bcl-2 axis, a finding which may be of great significance in the treatment of HIBD. +transcription factor target 35802903 hsa-mir-224 Fibrosis In vivo results show that treatment with antagomir-224 or liposomes containing miR-224 inhibitors suppresses fibrosis and improves muscle recovery. +exosome 35802880 hsa-mir-375 Breast Neoplasms The biomimetic vesicles prepared with MCF-7 cancer cell-derived membranes were shown to recognize estrogen receptor-positive breast cancer exosomes and exhibited a low detection limit of 557 particles mL(-1) with microRNA-375 used as the endogenous biomarker. +lncRNA target 35802304 hsa-mir-487b Spinal Cord Injuries For the first time, our results revealed that miR-487b may play an important regulatory role in SCI by targeted Ifitm3 and provide further evidence for SCI research. +lncRNA target 35802246 hsa-mir-34b Depression, Post Stroke Together, our data demonstrated that insufficient miR34b-3p after stroke cannot inhibit eIF4E translation, which causes PSD by the activation of microglia in the hippocampus. Therefore, miR34b-3p and eIF4E may serve as potential therapeutic targets for the treatment of PSD. +transcription factor target 35802043 hsa-mir-150 Osteoporosis The data showed that diabetes upregulated miR-150 expression through oxidative stress and suppressed FNDC5/Irisin by binding to its 3'-untranslated region. +genetics_GWAS 35800619 hsa-mir-27b Carcinoma, Hepatocellular Moreover, CA10 overexpression was associated with down-regulation of miR-27b in human HBV-related HCC tumor tissues with sW182* mutation. +genetics_GWAS 35800619 hsa-mir-27b Hepatitis B, Chronic Moreover, CA10 overexpression was associated with down-regulation of miR-27b in human HBV-related HCC tumor tissues with sW182* mutation. +target gene 35800618 hsa-mir-139 Osteosarcoma LINC01140 regulates osteosarcoma proliferation and invasion by targeting the miR-139-5p/HOXA9 axis. +other 35800215 hsa-mir-29b Muscular Atrophy Med1, Myod1, Nfkb1, Rela, and Camta1 were predicted and verified to be significantly upregulated in denervated muscle atrophy, from which 6 key TF-miRNA relationship pairs, including Med1-mir-1949, Med1-mir-146b, Myod1-mir-29b, Nfkb1-mir-21, Rela-mir-21, and Camta1-mir-132, were obtained. In the study, a potential miRNA-mRNA regulatory network was firstly constructed in denervated muscle atrophy, in which the mir-29b-COL1A1 and mir-133a-Ctgf pathways may provide new insights into the pathogenesis and treatment. +lncRNA target 35799888 hsa-mir-1224 Acute Lung Injury 5p is directly bound to the 3'-untranslated regions of PPAR-gamma and subsequently suppressed PPAR-gamma/AMPKalpha axis, thereby aggravating LPS-induced ALI in vivo and in vitro. +lncRNA target 35799888 hsa-mir-1224 Sepsis 5p is directly bound to the 3'-untranslated regions of PPAR-gamma and subsequently suppressed PPAR-gamma/AMPKalpha axis, thereby aggravating LPS-induced ALI in vivo and in vitro. +other 35799735 hsa-mir-210 Retinal Vein Occlusion CONCLUSION: In patients with CRVO combined with macular edema, HIF-1alpha mRNA and miR-210 were highly expressed in the aqueous humor, which may play an important role in the occurrence and development of the disease. +other 35799735 hsa-mir-210 Macular Edema CONCLUSION: In patients with CRVO combined with macular edema, HIF-1alpha mRNA and miR-210 were highly expressed in the aqueous humor, which may play an important role in the occurrence and development of the disease. +genetics_overexpression_suppress 35799645 hsa-mir-17 Neurotoxicity Syndromes CONCLUSION: Overexpressed miR +genetics_knock down_suppress 35799601 hsa-mir-29c Inflammation For the function of miR-29c-5p in ischemic stroke, the miR-29c-5p knockdown decreased the permeability and the tight junction protein (TJP) destruction of BMECs and ameliorated the inflammation induced by OGD-treated astrocytes. +other 35799072 hsa-mir-187 Carcinoma, Renal Cell Deciphering the role of miR-187-3p/LRFN1 axis in modulating progression, aerobic glycolysis and immune microenvironment of clear cell renal cell carcinoma. +genetics_knock down_suppress 35798695 hsa-mir-1277 Colorectal Neoplasms 5p was silenced, knockdown of HOTAIR was unable to reduce the oxaliplatin resistance in CRC cells. +other 35798238 hsa-mir-345 Carcinoma, Hepatocellular Mechanistically, RP11-386G11.10 acted as a competing endogenous RNA (ceRNA) for miR3p to regulate the expression of HNRNPU and its downstream lipogenic enzymes, leading to lipid accumulation in HCC cells and promoting their growth and metastasis. +genetics_overexpression_promote 35797350 hsa-mir-130a Breast Neoplasms Overexpression of miR-130a-3p inhibited the expression of NRARP and some Wnt/beta-catenin signaling pathway genes, as well as exerted anti-tumor effects as evidenced by decreased cell proliferation, AIG, and migration of BC cells. +genetics_overexpression_promote 35796939 hsa-mir-17 Stomach Neoplasms Thus, our data suggest that the overexpression of hsa_circ_0017252 suppresses GC malignancy by sponging miR +genetics_overexpression_promote 35796297 hsa-mir-326 Celiac Disease Results: Although miR-326 mRNA expression was significantly lower in CD patients (P = 0.001), no significant difference was observed in ETS1 mRNA level between the two groups (P = 0.54), but IL-17A was significantly overexpressed in CD patients (P=0.002). +exosome 35795997 hsa-mir-155 Acute Kidney Injury Thus, the present study demonstrated that exosomal miR155 mediated the communication between activated macrophages and injured tubules, leading to progression of AKI, which not only provide novel insights into the pathophysiology of AKI but also offer a new therapeutic strategy for kidney diseases. +genetics_overexpression_suppress 35795731 hsa-mir-887 Colorectal Neoplasms From in vivo experiments, overexpression of miR +lncRNA target 35795552 hsa-mir-98 pancreatic adenocarcinoma In conclusion, our study suggested that LINC02432/hsa-miR5p/HK2 axis may serve as a novel diagnostic, prognostic, and therapeutic target in PAAD treatment. +lncRNA target 35795482 hsa-mir-520c Hepatitis B Moreover, we discovered that HBV promoted EMT via the miR-520c-3p-PTEN to activate AKT-NFkappaB signaling pathway, leading to increased HCC migration and invasion. +other 35795226 hsa-mir-335 Pulmonary Fibrosis Analysis of the MDTE database (miRNAs derived from Transposable Elements) allowed the detection of 12 different miRNAs derived in evolution from transposons and associated with IPF (miR-31, miR-302, miR-326, miR-335, miR-340, miR-374, miR-487, miR-493, miR-495, miR-630, miR-708, miR-1343). +other 35795226 hsa-mir-1343 Pulmonary Fibrosis Analysis of the MDTE database (miRNAs derived from Transposable Elements) allowed the detection of 12 different miRNAs derived in evolution from transposons and associated with IPF (miR-31, miR-302, miR-326, miR-335, miR-340, miR-374, miR-487, miR-493, miR-495, miR-630, miR-708, miR-1343). +other 35795226 hsa-mir-495 Pulmonary Fibrosis Analysis of the MDTE database (miRNAs derived from Transposable Elements) allowed the detection of 12 different miRNAs derived in evolution from transposons and associated with IPF (miR-31, miR-302, miR-326, miR-335, miR-340, miR-374, miR-487, miR-493, miR-495, miR-630, miR-708, miR-1343). +other 35795226 hsa-mir-340 Pulmonary Fibrosis Analysis of the MDTE database (miRNAs derived from Transposable Elements) allowed the detection of 12 different miRNAs derived in evolution from transposons and associated with IPF (miR-31, miR-302, miR-326, miR-335, miR-340, miR-374, miR-487, miR-493, miR-495, miR-630, miR-708, miR-1343). +other 35795226 hsa-mir-708 Pulmonary Fibrosis Analysis of the MDTE database (miRNAs derived from Transposable Elements) allowed the detection of 12 different miRNAs derived in evolution from transposons and associated with IPF (miR-31, miR-302, miR-326, miR-335, miR-340, miR-374, miR-487, miR-493, miR-495, miR-630, miR-708, miR-1343). +other 35795226 hsa-mir-630 Pulmonary Fibrosis Analysis of the MDTE database (miRNAs derived from Transposable Elements) allowed the detection of 12 different miRNAs derived in evolution from transposons and associated with IPF (miR-31, miR-302, miR-326, miR-335, miR-340, miR-374, miR-487, miR-493, miR-495, miR-630, miR-708, miR-1343). +epigenetics 35795202 hsa-mir-454 Carcinoma, Non-Small-Cell Lung Therefore, we concluded that promoter hypermethylation of the 4.1N/EPB41L1 gene and abnormally high expressed miR +epigenetics 35795047 hsa-mir-370 Carcinoma, Hepatocellular Mechanistically, circASPH could regulate the methylation of the promoter and expression of hydrocyanic oxidase 2 (HAO2) to promote HCC progression by acting as a sponge for miR +target gene 35794978 hsa-mir-370 Pancreatic Neoplasms Deoxyelephantopin Suppresses Pancreatic Cancer Progression In Vitro and In Vivo by Targeting linc00511/miR-370-5p/p21 Promoter Axis. +other 35794963 hsa-mir-92b Venous Thromboembolism Applying a 1.5-fold difference and false discovery rate of <0.1, 19 tumor-miRNAs were differentially regulated in VTE cases versus controls, with hsa-miR-3652, hsa-miR-92b-5p, and hsa-miR-10,394-5p as most significantly downregulated. +other 35794963 hsa-mir-92b Colorectal Neoplasms Applying a 1.5-fold difference and false discovery rate of <0.1, 19 tumor-miRNAs were differentially regulated in VTE cases versus controls, with hsa-miR-3652, hsa-miR-92b-5p, and hsa-miR-10,394-5p as most significantly downregulated. +other 35794963 hsa-mir-10 Colorectal Neoplasms Applying a 1.5-fold difference and false discovery rate of <0.1, 19 tumor-miRNAs were differentially regulated in VTE cases versus controls, with hsa-miR-3652, hsa-miR-92b-5p, and hsa-miR-10,394-5p as most significantly downregulated. +other 35794963 hsa-mir-652 Venous Thromboembolism Applying a 1.5-fold difference and false discovery rate of <0.1, 19 tumor-miRNAs were differentially regulated in VTE cases versus controls, with hsa-miR-3652, hsa-miR-92b-5p, and hsa-miR-10,394-5p as most significantly downregulated. +other 35794963 hsa-mir-652 Colorectal Neoplasms Applying a 1.5-fold difference and false discovery rate of <0.1, 19 tumor-miRNAs were differentially regulated in VTE cases versus controls, with hsa-miR-3652, hsa-miR-92b-5p, and hsa-miR-10,394-5p as most significantly downregulated. +other 35794963 hsa-mir-10 Venous Thromboembolism Applying a 1.5-fold difference and false discovery rate of <0.1, 19 tumor-miRNAs were differentially regulated in VTE cases versus controls, with hsa-miR-3652, hsa-miR-92b-5p, and hsa-miR-10,394-5p as most significantly downregulated. +genetics_knock down_suppress 35794743 hsa-mir-99b Ovarian Neoplasms It was demonstrated in this study that knockdown of UCA1 inhibited ovarian cancer cell viability, which a miR-99b-3p inhibitor could reverse in vitro. Inhibition of UCA1/miR-99b-3p/SRPK1 axis may become a novel target for treating ovarian cancer. +lncRNA target 35794700 hsa-mir-885 Ovarian Neoplasms 5p, and hsalet7d-3p) having a diagnostic value in OC patients' sera, with high-throughput techniques. +lncRNA target 35794700 hsa-let-7d Ovarian Neoplasms 5p, and hsalet7d-3p) having a diagnostic value in OC patients' sera, with high-throughput techniques. +lncRNA target 35794700 hsa-mir-1909 Ovarian Neoplasms 5p, and hsalet7d-3p) having a diagnostic value in OC patients' sera, with high-throughput techniques. +transcription factor target 35794619 hsa-mir-32 Diabetes Mellitus, Type 2 CONCLUSIONS: These results reveal that EVs are the key pathway by which macrophages promote T2D VC, and that EVs miR-32 is a key cause of autophagy inhibition in VSMCs. +other 35794555 hsa-mir-139 Breast Neoplasms And PIK3CA and HRAS were related to the survival and prognosis of BC patients, the PIK3CA-hsa-mir5p-LINC01278 and PIK3CA-hsa-mir-375 pathways might be closely related to the mechanism of Syringin against BC. +other 35794555 hsa-mir-375 Breast Neoplasms And PIK3CA and HRAS were related to the survival and prognosis of BC patients, the PIK3CA-hsa-mir5p-LINC01278 and PIK3CA-hsa-mir-375 pathways might be closely related to the mechanism of Syringin against BC. +other 35794450 hsa-mir-576 Breast Neoplasms 3p/SOX4 axis in breast cancer, providing potential and exploitable diagnostic and therapeutic molecules for breast cancer. +genetics_overexpression_promote 35794445 hsa-mir-802 Femur Head Necrosis Overexpression of TRG-AS1 restrained Dex-induced inhibition of osteogenic differentiation, promoted CAB39/AMPK/SIRT-1 and inhibited NF-kappaB, while overexpression of miR-802 bridled the inhibitory effect of TRG-AS1 on OP. +genetics_overexpression_promote 35794445 hsa-mir-802 Osteoporosis Overexpression of TRG-AS1 restrained Dex-induced inhibition of osteogenic differentiation, promoted CAB39/AMPK/SIRT-1 and inhibited NF-kappaB, while overexpression of miR-802 bridled the inhibitory effect of TRG-AS1 on OP. +lncRNA target 35794253 hsa-mir-136 Stomach Neoplasms CONCLUSION: By regulating the PTEN/AKT signaling pathway through competitively binding with hsa-miR5p, hsa_circ_0006282 suppresses the growth of gastric cancer. +circulation_biomarker_prognosis_up 35793786 hsa-mir-1246 Multiple Myeloma CONCLUSION: This study demonstrates that circulating miR-1246 level is elevated in MM patients, which shows high values in the diagnosis and prognosis prediction in patients with MM. +genetics_GWAS 35793763 hsa-mir-223 Ischemic Stroke The combined detection of plasma microRNA-223 and cYP2c19 gene polymorphisms may be effective in predicting the occurrence of clopidogrel HTPR in patients with AIS. +genetics_knock down_suppress 35793478 hsa-mir-136 Sepsis Overall, lncRNA GAS6-AS2 knockdown has the potential to ameliorate sepsis-related AKI, and the mechanism is related to miR5p/OXSR1 axis. +genetics_knock down_suppress 35793478 hsa-mir-136 Acute Kidney Injury Overall, lncRNA GAS6-AS2 knockdown has the potential to ameliorate sepsis-related AKI, and the mechanism is related to miR5p/OXSR1 axis. +circRNA target 35793013 hsa-mir-24 Glioma Circ_0079593 triggered glioma development via miR +transcription factor target 35792987 hsa-mir-21 Fibrosis However, the regulative effect of liraglutide on atrial fibrosis via miR-21 and the underlying mechanism are still unclear. +other 35792987 hsa-mir-21 Atrial Fibrillation It has been reported that miR-21 modulated cardiac fibrosis in AF. +lncRNA target 35792605 hsa-mir-4458 Breast Neoplasms In this study, miR-4458 was upregulated in ER+ breast cancer and could inhibit MCF-7 cell viability, colony formation, migration, and invasion. In conclusion, GNs can be potentially used to deliver siRNA or miRNA, and miR-4458 and COL11A1 can be possible targets for ER+ breast cancer treatment. +transcription factor target 35792203 hsa-mir-223 Dmd-Associated Dilated Cardiomyopathy In summary, miR3p could be a potential therapeutic target for DCM. +other 35792203 hsa-mir-223 Hyperglycemia The above findings inspired us to propose a new signaling pathway to regulate scoria of cardiomyocytes under hyperglycemia: miR3p upward arrow--> SPI1 downward arrow--> caspase-1 upward arrow --> IL-1beta and other pyroptosis-associated poteins upward arrow--> pyroptosis upward arrow. +transcription factor target 35792203 hsa-mir-223 Necrobiotic Disorders 3p leading to pyroptosis, we found inhibition of miR +genetics_overexpression_promote 35792156 hsa-mir-6071 Carcinoma, Hepatocellular Further study showed that PTPN11 interference and specific inhibitors IACS-13909 abrogated the discrepancy of self-renewal ability, proliferation, migration and tumorigenicity capacity between miR-6071 overexpression HCC cells and control cells. +circulation_biomarker_prognosis_ns 35792028 hsa-mir-338 Cardiomyopathies Besides, serum miR +lncRNA target 35791923 hsa-mir-27b Osteoarthritis, Knee CONCLUSION: Our findings demonstrate that miR-27b-3p has a key role in ECM regulation associated with synovial fibrosis during OA. +genetics_overexpression_promote 35791807 hsa-mir-200c Non-alcoholic Fatty Liver Disease Overexpression of circ PTK2 suppresses the progression of nonalcoholic fatty liver disease via the miR-200c/SIK2/PI3K/Akt axis. +genetics_knock down_suppress 35791576 hsa-mir-153 Hypoxia-Ischemia, Brain In conclusion, knockdown of SNHG15 alleviated HI brain injury through modulating the miR3p/ SETD7 axis. +lncRNA target 35791460 hsa-mir-758 Cartilage Diseases Mechanistically, circNFIX acted as a sponge of miR758-3p and played a role in the chondrogenesis and chondrocyte degeneration by targeting the miR3p/KDM6A axis. +exosome 35791342 hsa-mir-142 Retinoblastoma Growth Inhibition of Retinoblastoma Cell Line by Exosome-Mediated Transfer of miR-142-3p. +other 35791074 hsa-mir-1286 Stomach Neoplasms CircCOL1A2 functions as a competing endogenous RNA (ceRNA) by sequestering microRNA-1286 (miR-1286) to modulate ubiquitin-specific peptidase 10 (USP10), which in turn spurs the migration and invasion of GC cells by regulating RFC2. In sum, CircCOL1A2 sponges miR-1286 to promote cell invasion and migration of GC by elevating the expression of USP10 to downregulate the level of RFC2 ubiquitination. +other 35790551 hsa-mir-6720 Bronchopulmonary Dysplasia Further, 455 circRNA/lncRNA-miRNA-mRNA interaction networks were predicted, including hsa_circ_0086913/hsa-miR-103a-3p/transmembrane 4 L six family member 1 (TM4SF1) and lncRNA-SNHG20/hsa-miR5p/spermine synthase (SMS) networks, which may take part in BPD. +other 35790551 hsa-mir-103a Bronchopulmonary Dysplasia Further, 455 circRNA/lncRNA-miRNA-mRNA interaction networks were predicted, including hsa_circ_0086913/hsa-miR-103a-3p/transmembrane 4 L six family member 1 (TM4SF1) and lncRNA-SNHG20/hsa-miR5p/spermine synthase (SMS) networks, which may take part in BPD. +genetics_knock down_promote 35790503 hsa-mir-375 Esophageal Squamous Cell Carcinoma Furthermore, miR-375 upregulation phenocopied circ_0000654 knockdown in inhibiting ESCC progression. CONCLUSION: Our findings identify a new circ_0000654/miR-375/E2F3 ceRNA crosstalk for the oncogenic role of circ_0000654 in ESCC and establish a notion that targeting circ_0000654 and its pathways may have the potential to improve ESCC outcome. +transcription factor target 35790441 hsa-mir-146a Glioma CONCLUSION: AVT can inhibit the proliferation, invasion and migration and promote apoptosis of human glioma cells possibly by up-regulating miR-146a expression and inhibiting the PI3K/Akt signaling pathway. +circulation_biomarker_diagnosis_ns 35790263 hsa-mir-4257 Colorectal Neoplasms CONCLUSION: miR-4257 level in plasma and cancer tissues is a biomarker of disease recurrence in patients with CRC. +genetics_GWAS 35789992 hsa-mir-205 Squamous Cell Carcinoma of Head and Neck nucleatum ) impacts HNSCC epigenetic changes in tissues with deficient MMR to promote DNA damage and cell proliferation by suppressing MMRrelated gene expression via the TLR4/MYD88/miR +circulation_biomarker_diagnosis_ns 35789846 hsa-mir-411 Carcinoma, Hepatocellular 5p was decreased in serum exosomes of nonalcoholic steatohepatitis (NASH) patients as compared with that in healthy controls. +lncRNA target 35789750 hsa-mir-200a COVID-19 Notably, blocking LASI lncRNA reduced the SARS-CoV-2 replication and suppressed MUC5AC mucin levels and associated inflammation, and select LASI-dependent miRNAs (e.g., let-7b-5p and miR-200a-5p) were implicated. +lncRNA target 35789750 hsa-let-7b COVID-19 Notably, blocking LASI lncRNA reduced the SARS-CoV-2 replication and suppressed MUC5AC mucin levels and associated inflammation, and select LASI-dependent miRNAs (e.g., let-7b-5p and miR-200a-5p) were implicated. +lncRNA target 35789750 hsa-let-7b Mucositis Notably, blocking LASI lncRNA reduced the SARS-CoV-2 replication and suppressed MUC5AC mucin levels and associated inflammation, and select LASI-dependent miRNAs (e.g., let-7b-5p and miR-200a-5p) were implicated. +lncRNA target 35789750 hsa-mir-200a Mucositis Notably, blocking LASI lncRNA reduced the SARS-CoV-2 replication and suppressed MUC5AC mucin levels and associated inflammation, and select LASI-dependent miRNAs (e.g., let-7b-5p and miR-200a-5p) were implicated. +genetics_overexpression_promote 35789645 hsa-mir-155 Stomach Neoplasms 5p was overexpressed in gastric cancer cells and clinical tissues, while Res inhibited gastric cancer cell growth by regulating miR +transcription factor target 35789312 hsa-mir-106b Status Epilepticus The miRNA miR-106b-5p has been linked to epilepsy, but its specific role and mechanism of action remain unclear. Our results suggest that therapeutic strategies targeting miR-106b-5p or downstream factors can be effective in preventing epileptogenesis or treating epilepsy. +lncRNA target 35789225 hsa-mir-21 Pancreatic Carcinoma Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. +genetics_knock down_suppress 35789143 hsa-mir-9 Small Cell Lung Carcinoma Notably, we found apparent de-repression of common target genes of different miRNAs following ASCL1 knockdown, suggesting combinatorial action of multiple miRNAs underlying molecular heterogeneity of SCLC (e.g., co-targeting of YAP1 by miR-9 and miR-375). +genetics_knock down_suppress 35789143 hsa-mir-375 Small Cell Lung Carcinoma Notably, we found apparent de-repression of common target genes of different miRNAs following ASCL1 knockdown, suggesting combinatorial action of multiple miRNAs underlying molecular heterogeneity of SCLC (e.g., co-targeting of YAP1 by miR-9 and miR-375). +lncRNA target 35788944 hsa-mir-183 Urinary Bladder Neoplasms 5p modulated not only PNPT1 but also Bcl2 modifying factor (BMF) to inhibit the mitochondrial outer membrane permeabilization (MOMP) in BC cells. +exosome 35788900 hsa-mir-126 Myocardial Infarction This study demonstrated that animal rat models' combination treatment with microRNA-126 and microRNA-146a mimics in exosomes is desirable for cardiac regeneration after myocardial infarction. +exosome 35788900 hsa-mir-146a Myocardial Infarction This study demonstrated that animal rat models' combination treatment with microRNA-126 and microRNA-146a mimics in exosomes is desirable for cardiac regeneration after myocardial infarction. +other 35788691 hsa-mir-146b Mycosis Fungoides However, 39 miRNAs, including miR3p, miR-150 and miR-146b, were specific to mycosis fungoides. +other 35788691 hsa-mir-150 Mycosis Fungoides However, 39 miRNAs, including miR3p, miR-150 and miR-146b, were specific to mycosis fungoides. +other 35788691 hsa-mir-142 Mycosis Fungoides However, 39 miRNAs, including miR3p, miR-150 and miR-146b, were specific to mycosis fungoides. +lncRNA target 35788362 hsa-mir-491 Stomach Neoplasms To our knowledge, this is the first study to demonstrate that FOCAD is a tumor suppressor, higher FOCAD levels might be a better prognostic marker of gastric cancer, and FOCAD/miR +lncRNA target 35787669 hsa-mir-614 Breast Neoplasms In contrast to CFAP20DC-AS1, miR3p was upregulated by Rh2, inhibiting proliferation but stimulating apoptosis of the MCF-7 cells. +lncRNA target 35787628 hsa-mir-1286 Carcinoma, Renal Cell Taken together, our findings on COL18A1-AS1-miR-1286/KLF12 axis revealed a potential mechanism of abnormal accumulation of lipids in ccRCC and could be a promising therapeutic target for ccRCC patients. +other 35787258 hsa-mir-96 Osteosarcoma LncRNA NDRG1 aggravates osteosarcoma progression and regulates the PI3K/AKT pathway by sponging miR-96-5p. +genetics_knock down_promote 35786646 hsa-mir-711 Stomach Neoplasms The knockdown of CD44 showed similar effects as miR-711 overexpression in GC cells. +lncRNA target 35786456 hsa-mir-27a Reperfusion Injury, Cerebral Ischemia Objective To investigate the role and molecular mechanism of miR-27a in cerebral ischemia reperfusion injury model in rats. Conclusion In the process of cerebral ischemia and reperfusion, the up-regulated miR-27a may induce ferroptosis through inhibiting SLC7A11, thus causing brain tissue damage. +lncRNA target 35786454 hsa-mir-20 Sepsis Conclusion LOC102640791 alleviates sepsis inflammatory response by sponging miR5p. +genetics_overexpression_promote 35786451 hsa-mir-151 Stomach Neoplasms 3p in exosomes of tumor cells overexpressing miR +lncRNA target 35786376 hsa-mir-29 Cognitive Dysfunction CONCLUSIONS: All the results provide evidence for the protective role of TAB against sevoflurane-induced cognitive impairments, which was achieved by alleviating neurotoxicity and neuroinflammation through differentially regulating miR +exosome 35785218 hsa-mir-138 Osteosarcoma Osteosarcoma Cell-Derived Exosomal ELFN1-AS1 Mediates Macrophage M2 Polarization via Sponging miR-138-5p and miR-1291 to Promote the Tumorgenesis of Osteosarcoma. +exosome 35785218 hsa-mir-1291 Osteosarcoma Osteosarcoma Cell-Derived Exosomal ELFN1-AS1 Mediates Macrophage M2 Polarization via Sponging miR-138-5p and miR-1291 to Promote the Tumorgenesis of Osteosarcoma. +other 35785160 hsa-mir-9 Breast Neoplasms Finally, we constructed a lncRNA KCNQ1OT1-LINC00665-TUG1/miR5p/CDH1 regulatory axis of the ceRNA network to explore the mechanism of BRCA progression. +genetics_overexpression_promote 35785045 hsa-mir-16 Osteosarcoma E2F3 overexpression or miR +other 35785034 hsa-let-7b Tuberculosis, Pulmonary CONCLUSION: Our data shows that interleukin-27 and CXCL10 are significantly related in pulmonary tuberculosis, and has-let-7b-5p and has-miR-30a-3p are also related to interleukin-27 and CXCL10. +lncRNA target 35785031 hsa-mir-199a Cardiomyopathies miR-199a-3p is thought to be strongly linked with the development of some myocardial diseases, but the influence of miR-199a-3p in MIRI remains unclear. This study might be helpful for the therapeutic method of MIRI through by regulating miR-199a-3p/mTOR. +other 35784838 hsa-mir-486 Tuberous Sclerosis Meanwhile, we found that the disorder of FGFR3, hsa-miR5p, and lnc-KCNH5-1 plays a key vital role in developing TLE+HS. +other 35784838 hsa-mir-486 Epilepsy, Temporal Lobe Meanwhile, we found that the disorder of FGFR3, hsa-miR5p, and lnc-KCNH5-1 plays a key vital role in developing TLE+HS. +other 35784724 hsa-mir-92b Hepatolenticular Degeneration 3p to regulate the expression of genes including Smad9, Mapk10, and Aldh3a2, which may participate in WD-related kidney injury. +epigenetics 35784716 hsa-mir-194 Coronary Artery Disease Our team found that hypomethylation of miR-194 could be an important mechanism of CAD. +transcription factor target 35784690 hsa-mir-181a Temporomandibular Joint Disorders Intra-articular injection of miR-181a-5p antisense oligonucleotide (ASO) could reduce the cartilage damage and alleviate UAC-induced TMJOA progression, but it did not restore injured subchondral bone. +transcription factor target 35784690 hsa-mir-181a Cartilage Diseases Intra-articular injection of miR-181a-5p antisense oligonucleotide (ASO) could reduce the cartilage damage and alleviate UAC-induced TMJOA progression, but it did not restore injured subchondral bone. +other 35784469 hsa-mir-205 Shock, Septic Moreover, enrichment of triplex-forming sequences was found upstream of MIR205HG/LEADR-bound genes, peaking at -1,500/-500 bp from TSS. +other 35784175 hsa-mir-299 Intervertebral Disc Degeneration CONCLUSION: The SNHG5/miR5p/ATF2 can be used as biomarker of IDD, and infiltration of immune cells plays an important role in the pathological development of IDD. +circulation_biomarker_diagnosis_down 35783838 hsa-mir-181a ST Elevation Myocardial Infarction CONCLUSION: Circulating exosome miR +other 35783531 hsa-mir-192 Pneumonia CONCLUSION: miR-223 and miR-192 can reflect coagulation function in children with SP, which can provide a certain reference basis for clinical guidance and treatment and prognosis. +other 35783531 hsa-mir-223 Pneumonia CONCLUSION: miR-223 and miR-192 can reflect coagulation function in children with SP, which can provide a certain reference basis for clinical guidance and treatment and prognosis. +circulation_biomarker_diagnosis_ns 35783530 hsa-mir-411 Lymphoma, Large B-Cell, Diffuse 5p bound to LINC00461 and BNIP3 and was negatively correlated with LINC00461 and BNIP3 mRNA in blood of DLBCL patients. +genetics_knock down_promote 35783190 hsa-mir-376a Osteosarcoma Furthermore, knockdown of miR-376a reversed the influences of MALAT1 silencing in osteosarcoma cells. +target gene 35783157 hsa-mir-205 Uterine Cervical Neoplasms LncRNA FAM13A-AS1 Regulates Proliferation and Apoptosis of Cervical Cancer Cells by Targeting miRNA-205-3p/DDI2 Axis. +lncRNA target 35783150 hsa-mir-5195 Pituitary Neoplasms ST8SIA6-AS1 targets miR +target gene 35783137 hsa-mir-26a Alzheimer Disease PTGS2 can be used as a target for AD research, and miR-26a-5p/PTGS2 can be used as an axis of action to study the pathogenesis of AD +lncRNA target 35783018 hsa-mir-136 Pneumonia, Mycoplasma More results indicated that high expression of miR-136 and low expression of N-cadherin appeared in PE. In terms of mechanism, circ_0055724 may induce the expression of N-cadherin and regulate the proliferation, migration, and invasion of trophoblast cells through decreasing miR-136, which can be a promising biomarker for early diagnosis and prognosis of patients with PE. +lncRNA target 35783017 hsa-mir-802 Colonic Neoplasms CONCLUSION: circIFITM1 facilitates the proliferative and invasive abilities via miR-802/FOXP1 in Lovo cells. +other 35783013 hsa-mir-142 Colorectal Neoplasms In conclusion, our work reveals the impacts of circIFT80 as ceRNA in the progression of CRC, by which sponging miR-142, miR-568, and miR-634 enhanced the expression levels of beta-catenin and activation Wnt/beta-catenin pathway. +other 35783013 hsa-mir-634 Colorectal Neoplasms In conclusion, our work reveals the impacts of circIFT80 as ceRNA in the progression of CRC, by which sponging miR-142, miR-568, and miR-634 enhanced the expression levels of beta-catenin and activation Wnt/beta-catenin pathway. +circulation_biomarker_diagnosis_up 35782940 hsa-mir-27a Obesity The level of serum exosomal miR-27a in the non-exercise obese group was increased obviously, which was reduced in the exercise obese groups. +target gene 35782903 hsa-let-7c Leukemia miR-let-7c-3p targeting on Egr-1 contributes to the committed differentiation of leukemia cells into monocyte/macrophages. +circulation_biomarker_diagnosis_up 35782895 hsa-mir-126 Breast Neoplasms Notably, circulating miR-126 level was decreased in the BC and OC groups, but not in the CF group. +transcription factor target 35782645 hsa-mir-21 Acute Lung Injury Therefore, this study was performed to examine the possible implication of NLRP3 inflammasome and miRNA-21 in the pathogenesis of the MTX-induced lung injury as well as the protective role of GB in ameliorating the induced lung injury. This study is the first report to reveal the involvement of NLRP3 inflammasome in the pathogenesis of MTX-induced lung injury and also to show that the administration of GB alleviates the lung injury induced by MTX via suppressing the oxidative stress, restoring the antioxidant activity, blocking the NLRP3/ASC/Caspase-1 signaling and downregulating the NF-kBp65 protein expression ae well as miRNA-21 expression in lung tissue. +genetics_overexpression_promote 35782228 hsa-mir-181c Cartilage Diseases Also, overexpression of SMAD7 inhibited the repairing effect of BMP2, and overexpression of BMP2 and miR-181c-5p further promoted the repair of cartilage injury in vivo. +lncRNA target 35782084 hsa-mir-1 Retinoblastoma CONCLUSION: lncRNA FOXD2-AS1 inhibited cell proliferation and migration via the miRNA-31/PAX9 axis in retinoblastoma. +lncRNA target 35782062 hsa-mir-339 Glioma 5p in glioma can regulate the proliferative, apoptotic, invasive, and migratory abilities of glioma U87 cells and might suppress the occurrence and development of glioma. +circulation_biomarker_diagnosis_up 35781746 hsa-mir-146a Sepsis In this study, the miR-146a-5p level was elevated in the serum of sepsis patients and LPS-induced DCs but decreased in the serums of cured sepsis patients. +genetics_knock down_promote 35781593 hsa-mir-135b Parkinson Disease Besides, miR-135b-5p interacted with the 3' untranslated region (3'UTR) of KPNA4, and KPNA4 overexpression partly reversed miR-135b-5p overexpression-induced effects in PD cell model. +lncRNA target 35781592 hsa-mir-21 Cognition Disorders Our study pins the role of miRNA-21 in modulating brain insulin signaling and hence alleviating cognitive dysfunction accompanying diabetes mellitus. +lncRNA target 35781592 hsa-mir-21 Diabetes Mellitus, Type 2 Our study pins the role of miRNA-21 in modulating brain insulin signaling and hence alleviating cognitive dysfunction accompanying diabetes mellitus. +other 35781287 hsa-mir-206 Cognition Disorders In this study, we aimed to elucidate the role of hUCMSCs with down-regulated miRNA-206 (hUCMSCs anti-miR-206) on cognitive decline and the underlying mechanism. +transcription factor target 35781221 hsa-mir-26a Cognition Disorders Three significant miRNAs (hsa-miR-26a-5p, hsa-miR-203a-3p, and hsa-miR5p) implicated in the etiology of DAB-induced cognitive impairment and targeted by curcumin were also identified. +transcription factor target 35781221 hsa-mir-203a Cognition Disorders Three significant miRNAs (hsa-miR-26a-5p, hsa-miR-203a-3p, and hsa-miR5p) implicated in the etiology of DAB-induced cognitive impairment and targeted by curcumin were also identified. +transcription factor target 35781221 hsa-mir-155 Cognition Disorders Three significant miRNAs (hsa-miR-26a-5p, hsa-miR-203a-3p, and hsa-miR5p) implicated in the etiology of DAB-induced cognitive impairment and targeted by curcumin were also identified. +other 35781028 hsa-mir-155 Intervertebral Disc Degeneration Moreover, downregulation of total ERK1/2 in hASCs and oNP cells, after miR-155 LNC treatment, was demonstrated by Western blot and quantitative reverse-transcription PCR (qRT-PCR), thus confirming maintenance of its bioactivity after formulation and internalization. +other 35780970 hsa-mir-28 Down Syndrome Among those, miR5p and let-7d-5p were found significantly decreased in physiological ageing ( oldest group ), thus they emerged as possible biomarkers of premature ageing in DS. +other 35780970 hsa-let-7d Down Syndrome Among those, miR5p and let-7d-5p were found significantly decreased in physiological ageing ( oldest group ), thus they emerged as possible biomarkers of premature ageing in DS. +circulation_biomarker_diagnosis_ns 35780970 hsa-mir-628 Down Syndrome Moreover, measuring blood levels of beta amyloid peptides, Abeta-42 was assessed at the lowest levels in physiological ageing and correlated with miR +other 35780710 hsa-mir-34c Influenza, Human CONCLUSION: Our data elucidated that UA attenuated IAV-triggered inflammatory responses and oxidative stress in A549 cells by regulating the miR-34c-5p/TLR5 axis, suggesting that UA plays a protective role in IAV-induced pneumonia. +lncRNA target 35780585 hsa-mir-222 Leukemia, Myeloid, Acute 3p increased the viability and suppressed the apoptosis of AML cells. +transcription factor target 35780573 hsa-mir-1306 Leukemia, Myeloid, Acute 5p may function as an oncogene in AML, providing a promising therapeutic target for AML patients. +circulation_biomarker_diagnosis_up 35779817 hsa-mir-101 Ischemic Stroke 3p was downregulated in the plasma of patients with IS but upregulated in the patients with neurological recovery after rt-PA intravenous thrombolysis. +circulation_biomarker_diagnosis_up 35779817 hsa-mir-101a Ischemic Stroke 3p was downregulated in the plasma of patients with IS but upregulated in the patients with neurological recovery after rt-PA intravenous thrombolysis. +lncRNA target 35779785 hsa-mir-140 Tuberculosis CONCLUSION: The present results suggested that SNHG16 may be a new diagnostic biomarker for TB patients and SNHG16 silencing may alleviate TB by inhibiting the proliferation of macrophages in TB by regulation miR +genetics_overexpression_suppress 35779698 hsa-mir-214 Dry Eye Syndromes Furthermore, KCNQ1OT1 knockdown and miR-214 overexpression reversed the effect of HS, promoted the migration of HCECs, and accelerated corneal wound healing. +other 35779530 hsa-mir-370 Uterine Cervical Neoplasms In conclusion, this research premise identified the biological function of circEPSTI1-miR3p-MSH2 axis in cervical cancer progression. +target gene 35779335 hsa-mir-590 Encephalitis Virus, Japanese miR-590-3p could directly target the expression levels of USP42 (Ubiquitin Specific Peptidase 42) resulting in increased cellular levels of USP42 upon JEV infection. +target gene 35779228 hsa-mir-134-2p Breast Neoplasms Reporter assays proved direct binding of miR-134-3p and miR-224-3p to the SOX9 3'-UTR in MDA-MB-231 and MCF-7 cells. +target gene 35779228 hsa-mir-224 Breast Neoplasms Reporter assays proved direct binding of miR-134-3p and miR-224-3p to the SOX9 3'-UTR in MDA-MB-231 and MCF-7 cells. +target gene 35779228 hsa-mir-6859 Breast Neoplasms Transfection of miR-134-3p, miR-224-3p, or miR-6859-3p reduced SOX9 expression on mRNA and protein level. +other 35779226 hsa-mir-146 Diabetic Cardiomyopathies 3p, miR-26a-3p) in diabetes-induced cardiac cells. +other 35779226 hsa-mir-7b Diabetic Cardiomyopathies 3p, miR-26a-3p) in diabetes-induced cardiac cells. +other 35779226 hsa-mir-586 Diabetic Cardiomyopathies 3p, miR-26a-3p) in diabetes-induced cardiac cells. +other 35779226 hsa-mir-3596d Diabetic Cardiomyopathies 3p, miR-26a-3p) in diabetes-induced cardiac cells. +other 35779226 hsa-mir-26a Diabetic Cardiomyopathies 3p, miR-26a-3p) in diabetes-induced cardiac cells. +other 35779226 hsa-mir-1249 Diabetic Cardiomyopathies 3p, miR-26a-3p) in diabetes-induced cardiac cells. +other 35779226 hsa-mir-328a Diabetic Cardiomyopathies 3p, miR-26a-3p) in diabetes-induced cardiac cells. +other 35779226 hsa-let-7i Diabetic Cardiomyopathies 3p, miR-26a-3p) in diabetes-induced cardiac cells. +lncRNA target 35778962 hsa-mir-145 Squamous Cell Carcinoma of Head and Neck CONCLUSION: Circ_0058063 could promote the malignant behavior of OSCC by upregulating SERPINE1 through sponging miR +circRNA target 35778952 hsa-mir-145 Diabetes Mellitus, Type 2 This study thus showed that hsa_circ_0115355 inhibits the occurrence and development of T2DM by regulating the expression of SIRT1 by adsorbing miR-145. +target gene 35778917 hsa-mir-363 T-cell acute lymphoblastic leukemia we show that miR-363-3p enhances cell growth of T-ALL in vitro via inhibition of PTPRC and SOCS2, which are implicated in repression of the JAK-STAT pathway. +other 35778809 hsa-mir-200a Erectile Dysfunction In this study, aged rats were divided into AE group (aged rats with ED) and YN group (young normal rats) for evaluating the roles of miRNA-200a and RhoA/ROCK signalling pathway in A-ED. +genetics_overexpression_suppress 35778755 hsa-mir-874 Nasopharyngeal Carcinoma Overexpression of miR-874-3p prevented cell growth, motility, glucose consumption, and lactate production in NPC cells, whereas miR-874-3p inhibition had the opposite effects. +target gene 35778656 hsa-mir-1307 Urinary Bladder Neoplasms miR-1307-5p suppresses proliferation and tumorigenesis of bladder cancer via targeting MDM4 and the Hippo signaling pathway. +other 35778654 hsa-mir-19b Heart Defects, Congenital RNA-seq profiling and dual-luciferase reporter assay revealed that NKX2-5 acts upstream of PYK2 via miR-19a and miR-19b (miR-19a/b) to regulate cardiomyocyte apoptosis. +other 35778654 hsa-mir-19a Heart Defects, Congenital RNA-seq profiling and dual-luciferase reporter assay revealed that NKX2-5 acts upstream of PYK2 via miR-19a and miR-19b (miR-19a/b) to regulate cardiomyocyte apoptosis. +lncRNA target 35778646 hsa-mir-204 Esophageal Squamous Cell Carcinoma We further confirmed that FOXD2-AS1 was the upstream inhibitor of miR-204-3p and the down-regulation of miR-204-3p reversed the repressive effects of low expression of FOXD2-AS1 on ESCC progression. +lncRNA target 35778520 hsa-mir-10 Carcinoma, Hepatocellular Moreover, we conduct upstream miRNAs and lncRNAs of TOP2A to establish ceRNA networks in kidney renal clear cell carcinoma (SNHG3-miR-139-5p), kidney renal papillary cell carcinoma (TMEM147-AS1/N4BP2L2-IT2/THUMPD3-AS1/ERICD/TTN-AS1 liver hepatocellular carcinoma (SNHG3/THUMPD3-AS1/NUTM2B-AS1/NUTM2A-AS1-miR-139-5 and SNHG6/GSEC/SNHG1/SNHG14/LINC00265/MIR3142HG-miR-10 and lung adenocarcinoma (TYMSOS/HELLPAR/SNHG1/GSEC/SNHG6-miR-101-3p). +lncRNA target 35778520 hsa-mir-101 Adenocarcinoma of Lung Moreover, we conduct upstream miRNAs and lncRNAs of TOP2A to establish ceRNA networks in kidney renal clear cell carcinoma (SNHG3-miR-139-5p), kidney renal papillary cell carcinoma (TMEM147-AS1/N4BP2L2-IT2/THUMPD3-AS1/ERICD/TTN-AS1 liver hepatocellular carcinoma (SNHG3/THUMPD3-AS1/NUTM2B-AS1/NUTM2A-AS1-miR-139-5 and SNHG6/GSEC/SNHG1/SNHG14/LINC00265/MIR3142HG-miR-10 and lung adenocarcinoma (TYMSOS/HELLPAR/SNHG1/GSEC/SNHG6-miR-101-3p). +other 35777901 hsa-mir-155 Hypoxia METHODS: Immunostaining, western blot and quantitative real-time reverse transcription PCR (qRT-PCR) were performed to detect the expression of glucose transporter 5 (GLUT5), ketohexokinase (KHK)-A and KHK-C in miR-155(-/-) and miR-155(wt) CFs under normoxia or hypoxia. RESULTS: When both miR-155(-/-) and miR-155(wt) CFs were exposed to hypoxia for 24 h, these two cells exhibited an increased glycolysis and decreased glycogen synthesis, and the expression of KHK-A and KHK-C, the central fructose-metabolizing enzyme, was upregulated. +lncRNA target 35777805 hsa-mir-497 Thyroid Cancer, Papillary Our findings demonstrated that down-regulation of CERS6-AS1 reduced cell viability and amplified cell ferroptosis by modulating the miR-497-5p/LASP1 axis in papillary thyroid cancer. +target gene 35777802 hsa-mir-146a Pancreatitis Luciferase assay confirmed miR-146a-5p can directly target IRAK1 and TRAF6. Overexpression of miR-146a-5p ameliorates inflammation and autophagy in TLCs-treated AR42J cells by inhibiting IRAK1/ TRAF6/NF-kappaB pathway. +epigenetics 35777791 hsa-mir-186 Endometrial Neoplasms CONCLUSION: Therefore, circSEPT9 is upregulated in EC and promotes cell invasion and migration by downregulating miR-186 through methylation. +genetics_overexpression_promote 35777757 hsa-mir-200c Cardiomegaly these effects then led to reduced binding of GAS5 to miR-495-3p, increased miR-495-3p expression, and repression of PHF8 transcription. Through these mechanisms, our data indicate that KDM3C-dependent epigenetic modification promotes CH. +target gene 35777757 hsa-mir-495 Cardiomegaly KDM3C upregulated miR-200c-3p expression through demethylation of H3K9me2, leading to enhanced binding of miR-200c-3p to GAS5 and suppression of GAS5 expression; these effects then led to reduced binding of GAS5 to miR-495-3p, increased miR-495-3p expression, and repression of PHF8 transcription. +target gene 35777302 hsa-mir-25 Osteoporosis miR-25-3p targets ITGB3, thereby suppressing osteogenic differentiation of BMSCs from OP patients. +circRNA target 35777132 hsa-mir-497 Prostatic Neoplasms CircPDHX stimulated PCa development via miR-497-5p/ACSL1, which presented a new thought for PCa treatment. +transcription factor target 35776536 hsa-mir-210 Hypoxia KEY RESULTS: Hypoxia increased mtROS and suppressed mitochondrial respiration in uterine arteries, which were also produced by miR-210 mimic to normoxic arteries and blocked by antagomir miRLNA in hypoxic arteries. +circRNA target 35776379 hsa-mir-1229 Glioblastoma Moreover, miR-1229-3p could be targeted by circVPS18; inhibition of miR-1229-3p could invert the suppressive effect of circVPS18 knockdown on glioblastoma tumorigenesis. +lncRNA target 35776288 hsa-mir-629 Aortic Valve Disease 3p targeting TAGLN, validating that it is a potential therapeutic target for inhibiting CAVD. +other 35776220 hsa-let-7e Thyroid Neoplasms Elevated LINC00894 relieves the oncogenic properties of thyroid cancer cell by sponging let-7e-5p to promote TIA-1 expression. +circRNA target 35775884 hsa-mir-1182 Carcinoma, Hepatocellular Silencing circ_0061395 inhibited the malignant behavior of HCC cells by releasing miR-1182. Circ_0061395 induced the changes of the expression of SPOCK1 by regulating miR-1182, thereby mediating the process of HCC, and at least partially promoting the development of HCC cells, providing a novel targeted therapy for HCC. +circulation_biomarker_diagnosis_down 35775826 hsa-mir-212 Atherosclerosis As a result, DLEU2 and YWHAZ were up-regulated, and miR-212-5p was down-regulated in atherosclerosis serum. +circulation_biomarker_diagnosis_down 35775783 hsa-mir-141 Prostatic Neoplasms The level of miR141 was significantly lower in PCa cases than healthy individuals (p=0,004), and miR155 was significantly higher (p=0,005) in PCa cases. +other 35775783 hsa-mir-125b Prostatic Neoplasms Tumor mass were found to be associated with the level of miR-125b and miR-145. +circulation_biomarker_diagnosis_up 35775783 hsa-mir-155 Prostatic Neoplasms The level of miR141 was significantly lower in PCa cases than healthy individuals (p=0,004), and miR155 was significantly higher (p=0,005) in PCa cases. +other 35775783 hsa-mir-145 Prostatic Neoplasms Tumor mass were found to be associated with the level of miR-125b and miR-145. +tissue_expression_up 35775773 hsa-mir-126 Heart Failure Results Dramatic increase of ICAM-1 level in activated PBMCs of CHF patients, as well as an increase of the IL-10, ICAM-1 and TNF-alpha levels in the culture medium was observed. It was accompanied by CHF-related miRNA-126 overexpression in PBMCs. +other 35775701 hsa-mir-638 Breast Neoplasms Alterations in miR-638 may be used with 5-FU chemotherapy during NAC for BC. +other 35774792 hsa-mir-146a Multiple Sclerosis We found an association between miR.146a.5p (r(s):0.434, p=0.03) and miR.9.5p (r(s):0.516, p=0.028) with EDSS; +other 35774792 hsa-mir-9 Multiple Sclerosis We found an association between miR.146a.5p (r(s):0.434, p=0.03) and miR.9.5p (r(s):0.516, p=0.028) with EDSS; Regarding to the brain volume, miR.9.5p correlated with thalamus (r(s):-0.545, +other 35774792 hsa-mir-223 Multiple Sclerosis and miR-223.3p with caudate (r(s):0.46, p=0.04). +other 35774792 hsa-mir-126 Multiple Sclerosis and miR-146a.5p (r(s):-0.476, p=0.016) and miR-126.3p (r(s):-0.528, p=0.007) with SDMT. +other 35774792 hsa-mir-138 Multiple Sclerosis miR-138.5p with amygdala (r(s):0.73, p=0.016) and pallidum (r(s):0.64, p=0.048); +other 35774792 hsa-mir-200c Multiple Sclerosis miR.200c.3p with pallidum (r(s):-0.68, p=0.002) and cerebellum (r(s):-0.472, p=0.048); +other 35774498 hsa-mir-4488 Precursor Cell Lymphoblastic Leukemia-Lymphoma In AML, hsa-miR-4516 and hsa-miR-4488 correlated positively with HLA-G5 mRNA, but the HLA-G5 negatively correlated with sHLA-G. +other 35774498 hsa-mir-5096 Precursor Cell Lymphoblastic Leukemia-Lymphoma The hsa-miR-4488 and hsa-miR-5096 expression levels were lower in B-ALL than in AML, while that of hsa-miR5p was lower in T-ALL than in AML. +other 35774498 hsa-mir-486 Precursor Cell Lymphoblastic Leukemia-Lymphoma The hsa-miR-4488 and hsa-miR-5096 expression levels were lower in B-ALL than in AML, while that of hsa-miR5p was lower in T-ALL than in AML. +circulation_biomarker_diagnosis_up 35774277 hsa-mir-222 Mycoplasma pneumoniae pneumonia We found that, compared to normal, MPP patients exhibited a significant up-regulated miR-222-3p. +other 35773744 hsa-mir-133b Colorectal Neoplasms CONCLUSIONS: Our findings not only reveal the pivotal roles of circEZH2 in modulating CRC progression, but also advocate for attenuating circEZH2/miR-133b/IGF2BP2/ CREB1 regulatory axis to combat CRC. +lncRNA target 35773374 hsa-mir-656 Colorectal Neoplasms Therefore, RPL34-AS1 is downregulated in CRC and may sponge miR-3656 to suppress cell proliferation in CRC. +genetics_GWAS 35772782 hsa-mir-885 COVID-19 Interestingly, human endothelial cells treated with serum from COVID-19 patients release significantly less miR-145 and miR-885, exhibit increased apoptosis, and display significantly impaired angiogenetic properties compared with cells treated with non-COVID-19 serum. +genetics_GWAS 35772782 hsa-mir-145 COVID-19 Interestingly, human endothelial cells treated with serum from COVID-19 patients release significantly less miR-145 and miR-885, exhibit increased apoptosis, and display significantly impaired angiogenetic properties compared with cells treated with non-COVID-19 serum. +genetics_GWAS 35772782 hsa-mir-145 Thrombosis Interestingly, human endothelial cells treated with serum from COVID-19 patients release significantly less miR-145 and miR-885, exhibit increased apoptosis, and display significantly impaired angiogenetic properties compared with cells treated with non-COVID-19 serum. +genetics_GWAS 35772782 hsa-mir-885 Thrombosis Interestingly, human endothelial cells treated with serum from COVID-19 patients release significantly less miR-145 and miR-885, exhibit increased apoptosis, and display significantly impaired angiogenetic properties compared with cells treated with non-COVID-19 serum. +transcription factor target 35772682 hsa-mir-1184 Cardiomyopathies Moreover, miR-1184 inhibited the H(2)O(2)-induced myocardial injury by targeting RIPK1. +transcription factor target 35772657 hsa-mir-34c Femur Head Necrosis Our results underline the critical importance of the miR-34c-5p/MDM4 pathway in regulating the adipogenic outcome of BMSCs, suggesting the miR-34c-5p as a potentially effective therapeutic target in SONFH. +lncRNA target 35772605 hsa-mir-661 Glioma Moreover, siMdm2 reversed the effects of miR-661 inhibitor on the biological characteristics and Mdm2/p53/p21 expression of glioma cells. +genetics_knock down_promote 35772185 hsa-mir-127 Neuroblastoma 5p counteracted the inhibitory impact of circ_0135889 knockdown on the malignant behaviors of NB cells. +genetics_overexpression_promote 35771766 hsa-mir-4516 Vitreoretinopathy, Proliferative MiR-4516 suppressed experimental PVR in vitro and in vivo. In conclusion, the overexpression of miR-4516 suppresses TGF-beta2-induced EMT in a PVR model, and its role in PVR depends on OTX1/ERK. +circRNA target 35771357 hsa-mir-11181 Carcinoma, Pancreatic Ductal CONCLUSIONS: In conclusion, circ-0047078 plays a role in promoting PDAC via miR-11181 and then via CXCL12, MCAM and RGS16. +other 35771149 hsa-mir-613 Stomach Neoplasms VEGFA served as an important effector for the NUTM2A-AS1/miRregulated resistance of GC cells to matrine. +lncRNA target 35770722 hsa-let-7c Breast Neoplasms In particular, let-7c-5p is designated as a tumor suppressor in breast cancer. Taken together, our study demonstrated WA-mediated miRNA expression, in particular, upregulation of miR-let-7c-5p, leads to the inhibition of breast cancer cells derived mammospheres. +other 35770405 hsa-mir-1 Insulin Resistance Here we summarize the current understanding of the health-promoting effects of exerkines secreted from skeletal muscle, adipose tissue, bone, and liver, including MOTS-c, BDNF, miR-1, 12,13-diHOME, irisin, SPX, OC, GDF15, and FGF21 on obesity, insulin resistance, and type 2 diabetes. +other 35770405 hsa-mir-1 Obesity Here we summarize the current understanding of the health-promoting effects of exerkines secreted from skeletal muscle, adipose tissue, bone, and liver, including MOTS-c, BDNF, miR-1, 12,13-diHOME, irisin, SPX, OC, GDF15, and FGF21 on obesity, insulin resistance, and type 2 diabetes. +other 35770405 hsa-mir-1 Diabetes Mellitus, Type 2 Here we summarize the current understanding of the health-promoting effects of exerkines secreted from skeletal muscle, adipose tissue, bone, and liver, including MOTS-c, BDNF, miR-1, 12,13-diHOME, irisin, SPX, OC, GDF15, and FGF21 on obesity, insulin resistance, and type 2 diabetes. +genetics_GWAS 35770306 hsa-mir-196a-2 Myotonic Disorders Quantitative synthesis suggests that the miR-196a2 rs11614913 genetic variant is significantly correlated with the reduced risk of overall cancer in CDM2, CDM3, RM, and AM (odds ratio < 1 and P < .05). +lncRNA target 35770296 hsa-mir-603 Ovarian Neoplasms DNMT3A was found to promote the Warburg effect, cell proliferation, migration, and invasion of ovarian cancer by inhibiting the expression of miR-603. +circulation_biomarker_diagnosis_ns 35769889 hsa-mir-122 Non-alcoholic Fatty Liver Disease Our case-control study was to address the value of circulating miRNA-122 and serum pro-neurotensin as a potential non-invasive biomarker for the diagnosis of non-alcoholic fatty acid diseases. +lncRNA target 35769676 hsa-mir-205 Glioma In conclusion, HCP5 silencing suppressed glioma progression through the HCP5-miR +genetics_knock down_suppress 35769514 hsa-mir-940 Carcinoma, Hepatocellular downregulated expression was also found in HCC patients, and importantly, miR-940 inhibition reversed circACTG1 expression in 97H cells with circACTG1 knockdown. +lncRNA target 35769097 hsa-mir-206 Non-alcoholic Fatty Liver Disease MALAT1 regulated PPARalpha/CD36 -mediated hepatic lipid accumulation in NAFLD through regulation of miR-206/ARNT axis. Thus, MALAT1/miR-206/ARNT might serve as a therapeutic target against NAFLD. +lncRNA target 35769053 hsa-mir-29a Osteonecrosis CONCLUSIONS: MiR-29a-3p can modulate FOXO3 expression and Wnt/beta-catenin signaling to inhibit viability and osteogenic differentiation of hBMSCs, thereby promoting the development of steroid-associated osteonecrosis. +lncRNA target 35768865 hsa-mir-96 Ovarian Neoplasms CONCLUSIONS: Our findings indicate that circFBXO7 acts as a bone fide tumor suppressor in ovarian cancer and that the circFBXO7/miR5p/MTSS1 axis is an important regulator in the Wnt/beta-catenin signaling pathway which may provide a promising target for ovarian cancer therapy. +genetics_GWAS 35767710 hsa-mir-21 Myocardial Infarction In this study, we systematically reviewed the results of published papers on the therapeutic effect of miR-21 for myocardial infarction. This review provides insights into the future advancement of safe miR-21 -based genetic therapy in the treatment of myocardial infarction. +transcription factor target 35767307 hsa-mir-150 Colorectal Neoplasms In vivo and in vitro studies showed that the viability and invasion of CRC cells were both significantly suppressed by ExomiR-150. +transcription factor target 35767105 hsa-mir-19b Lung Neoplasms Among them, miR-19a/b exerts an oncogenic effect by suppressing tumor suppressor genes, including PTEN and TP53INP1in numerous types of cancers, including NSCLC. +transcription factor target 35767105 hsa-mir-19a Lung Neoplasms Among them, miR-19a/b exerts an oncogenic effect by suppressing tumor suppressor genes, including PTEN and TP53INP1in numerous types of cancers, including NSCLC. +genetics_knock down_promote 35766911 hsa-mir-136 Osteochondritis Dissecans CONCLUSION: Circ_TLK1 knockdown ameliorated OGD/R-induced PC12 cell injury by modulating miR +lncRNA target 35766445 hsa-mir-145 Colorectal Neoplasms 5p was disclosed to block CRC via overturning MACC1. +lncRNA target 35765992 hsa-mir-143 Cardiomegaly Inhibition of miRNA +transcription factor target 35765958 hsa-mir-652 Carcinoma, Non-Small-Cell Lung 3p-inhibitor to explore the role of PTEN ubiquitination and miR +lncRNA target 35765903 hsa-mir-222 Stomach Neoplasms Our study demonstrates that EZH2 promotes GC development via the modulation of miR +other 35765893 hsa-mir-140 Adrenocortical Carcinoma 3p in ACC progress. +lncRNA target 35765408 hsa-mir-338 Leukemia, Myeloid, Acute CONCLUSION: Casticin promotes AML cell apoptosis but inhibits AML cell proliferation in vitro and tumor growth in vivo by upregulating miR +genetics_overexpression_promote 35765282 hsa-mir-4735 Stomach Neoplasms 3p overexpression suppressed cell migration and invasion of GC cells, which were antagonized by overexpression of NEDD9. +target gene 35765275 hsa-mir-487a Osteosarcoma KLF5-induced miR-487a augments the progression of osteosarcoma cells by targeting NKX3-1 in vitro. +other 35765274 hsa-mir-21 Lung Neoplasms Nicotine-induced miR-21-3p promotes chemoresistance in lung cancer by negatively regulating FOXO3a. +target gene 35765271 hsa-mir-409 Ovarian Neoplasms MicroRNA-409-5p inhibits cell proliferation, and induces G(2)/M phase arrest and apoptosis by targeting DLGAP5 in ovarian cancer cells. +genetics_GWAS 35764886 hsa-mir-142 Myeloproliferative Disorders To extend knowledge about the occurrence of MIR142 mutations, we sequenced the gene in a large panel of MPNs [~ 700 samples, including polycythemia vera, essential thrombocythemia, primary myelofibrosis (PMF), and chronic myeloid leukemia], neoplasm types in which such mutations have never been tested, and in panels of acute myeloid leukemia (AML), and chronic lymphocytic leukemia (CLL). In summary, mutations in MIR142 are rare in MPNs; however, in specific subtypes, such as PMF, their frequency may be comparable to that observed in CLL or AML. +genetics_GWAS 35764155 hsa-mir-93 Urinary Bladder Neoplasms This study also shows that the combination of genetic markers (PON1 and CYP17A1) and miRNA (miR +circulation_biomarker_diagnosis_ns 35764071 hsa-mir-146a Arthritis, Rheumatoid CONCLUSIONS: These results suggested that miR-146a may be used as a disease progression marker in the peripheral blood of elder RA patients. +other 35764065 hsa-mir-197 Osteoporosis-pseudoglioma syndrome Circ_0062582 and SMAD5 were downregulated and miR3p was upregulated in OP patients and increased in osteoblast medium (OM)-induced hBMSCs in vitro. +other 35764020 hsa-mir-146a Urinary Retention Then, the in vitro effect of miR-146a-5p on the M1/M2 polarization and the secretion of inflammatory cytokines was investigated in Tamm-Horsfall protein-1 (THP-1)-induced macrophages. +lncRNA target 35764020 hsa-mir-146a Cryopyrin-Associated Periodic Syndromes In conclusion, miR-146a-5p enhances embryo survival in URSA by promoting decidual macrophage polarization toward an M2 phenotype, giving new ideas and potential targets for subsequent research on the pathogenesis and immunotherapeutic strategies of URSA. +circulation_biomarker_prognosis_up 35763793 hsa-mir-375 Respiratory Distress Syndrome, Newborn CONCLUSION: Umbilical cord serum miR-375 is elevated and associated with NRDS onset and clinical outcomes in NRDS neonates. +other 35763386 hsa-mir-1207 Colonic Neoplasms 5p level and enhancing the Wnt6/beta-catenin2 pathway. +other 35763314 hsa-mir-484 Leukemia, Myeloid, Acute We identified new multiomics molecular signatures of relevance to AML: miRNAs (e.g., mir-484 and miR-519d-3p), receptors (ACVR1 and PTPRG), transcription factors (PRDM14 and GATA3), and metabolites (in particular, amino acid derivatives). +other 35763314 hsa-mir-519d Leukemia, Myeloid, Acute We identified new multiomics molecular signatures of relevance to AML: miRNAs (e.g., mir-484 and miR-519d-3p), receptors (ACVR1 and PTPRG), transcription factors (PRDM14 and GATA3), and metabolites (in particular, amino acid derivatives). +circRNA target 35763173 hsa-mir-516b Glioma In addition, IFI30 was a direct target of miR-516b-5p, and miR-516b-5p inhibited glioma cell malignant behaviors by targeting IFI30 in propofol-treated cells. +genetics_overexpression_promote 35762276 hsa-mir-196a Carcinoma, Hepatocellular Overexpressed miR +genetics_overexpression_promote 35762276 hsa-mir-370 Carcinoma, Hepatocellular Overexpressed miR +lncRNA target 35762105 hsa-mir-219 Glioblastoma Given the tumour suppressing function of miR-219, and advantage of CS-NPs for gene delivery to the central nervous system, the presented NPs have a great potential for treatment of GBM. +other 35761975 hsa-mir-409 Prostatic Neoplasms 3p, and VEGF scales can provide reference value for clinical guidance of prostate carcinoma prognosis. +other 35761975 hsa-mir-23 Prostatic Neoplasms 3p, and VEGF scales can provide reference value for clinical guidance of prostate carcinoma prognosis. +circulation_biomarker_diagnosis_up 35761942 hsa-mir-204 Endometrial Neoplasms 5p expression is associated with lymph node metastasis in these SLN(+) EC tissues, indicating that the downregulation of serum miR +exosome 35761836 hsa-mir-146a Diabetic Retinopathy Our study demonstrated that BMSC exosomal miR-146a can regulate the inflammatory response of DR by mediating the TLR4/MyD88/NF-kappaB pathway, providing an experimental basis for the prevention and treatment of DR. +exosome 35761836 hsa-mir-146a Inflammation Our study demonstrated that BMSC exosomal miR-146a can regulate the inflammatory response of DR by mediating the TLR4/MyD88/NF-kappaB pathway, providing an experimental basis for the prevention and treatment of DR. +other 35761801 hsa-mir-124 Vitreoretinopathy, Proliferative Collectively, these findings suggest that miR-124/LIN7C can modulate EMT and cell migration in RPE cells, which may have therapeutic implications in the management of PVR diseases. +other 35761801 hsa-mir-124 Retinal Neovascularization Collectively, these findings suggest that miR-124/LIN7C can modulate EMT and cell migration in RPE cells, which may have therapeutic implications in the management of PVR diseases. +lncRNA target 35761386 hsa-mir-124 Osteosarcoma CONCLUSION: EBF1 induced-FGA5-AS1 aggravated osteosarcoma cell malignancy by targeting miR +genetics_overexpression_promote 35761379 hsa-mir-493 Leukemia, Myeloid, Acute 5p reversed the effects of overexpressed MEG3 on AML cells. +exosome 35761332 hsa-mir-29b Muscular Atrophy In our previous study, repressing miR-29b has been shown to reduce muscle atrophy. Our work demonstrates an engineered extracellular vesicles delivery of the miR-29b editing system, which could be potentially used for muscle atrophy therapy. +lncRNA target 35761326 hsa-mir-346 Leishmaniasis According to our results, the cfa-miR-346 appears to be linked to infection, and understanding its role and identifying its target genes could contribute to elucidate the mechanisms underlying the host-pathogen interaction in leishmaniasis. +lncRNA target 35761309 hsa-mir-144 Diabetes Mellitus, Type 2 CONCLUSION: The up-regulation of miR3p suppressed USP22/SIRT1 to induce ferroptosis, which causes pancreatic beta cells dysfunction, thereby promoting T2DM development. +genetics_knock down_promote 35761154 hsa-mir-21 Laryngeal Neoplasms 5p knockdown in developing laryngeal carcinoma cells. +other 35761105 hsa-mir-29 Diabetes Mellitus, Type 2 MiR-29 (P=0.001) changed significantly in the DD group compared to the control group. +other 35761105 hsa-mir-146a Diabetes Mellitus, Type 2 MiR-146a changed significantly (P=0.006) in both SD and DD groups compared to the control group. +lncRNA target 35760798 hsa-mir-20b Carcinoma, Hepatocellular The results indicated that the deficiency of miR-15a and miR-20b contributed to sorafenib resistance, whereas exogenous expression of miR-15a and miR-20b enhanced sorafenib sensitivity of HCC cells by cell viability, colony formation, and flow cytometry analyses. Taken together, our findings reveal crucial roles of miR-15a, miR-20b, CDC37L1, and PPIA in sorafenib response of HCC cells. +genetics_overexpression_promote 35760009 hsa-mir-200a Prostatic Neoplasms Remarkably, colony formation and cell migration were suppressed while cell cycle arrest and apoptosis were induced in prostate cancer cells overexpressing miR-200a and miR-320a. miR-200a and miR-320a were found to be upregulated in TP73-AS1 suppressed prostate cancer cells. +genetics_overexpression_promote 35760009 hsa-mir-20a Prostatic Neoplasms Remarkably, colony formation and cell migration were suppressed while cell cycle arrest and apoptosis were induced in prostate cancer cells overexpressing miR-200a and miR-320a. miR-200a and miR-320a were found to be upregulated in TP73-AS1 suppressed prostate cancer cells. +other 35759812 hsa-mir-146a Inflammation We aimed to explore how microRNA(miR)-146a, a negative regulator of inflammation, influences osteogenesis in DO. +lncRNA target 35759812 hsa-mir-146a Mandibular Diseases First, we established canine right mandibular DO and bone fracture models to evaluate the expression level of miR-146a in response to these procedures. In summary, miR-146a regulates mandibular DO by improving osteogenesis, and can serve as a potential target to shorten the therapy period of DO. +lncRNA target 35759812 hsa-mir-146a Disorders of Excessive Somnolence In summary, miR-146a regulates mandibular DO by improving osteogenesis, and can serve as a potential target to shorten the therapy period of DO. +other 35759812 hsa-mir-146a Fractures, Bone First, we established canine right mandibular DO and bone fracture models to evaluate the expression level of miR-146a in response to these procedures. +lncRNA target 35759451 hsa-mir-19a Nasopharyngeal Carcinoma The rescue experiments showed that BAMBI downregulation reversed the role of miR-19a-3p inhibition in NPC cells. +genetics_knock down_promote 35759163 hsa-mir-1184 Nasopharyngeal Carcinoma Circ_0000523 overexpression promoted NPC cell proliferation and accelerated cell cycle progression, whereas miR-1184 overexpression reversed these effects; circ_0000523 knockdown suppressed NPC cell proliferation and induced cell cycle arrest, while miR-1184 inhibition counteracted these effects. +genetics_knock down_promote 35759156 hsa-mir-432 Colorectal Neoplasms MYH9 overexpression counteracted the inhibiting effects of miR +other 35758549 hsa-mir-126a Multiple Sclerosis Specifically, miR-126a-5p in microglia is positively correlated with BBB integrity in four types of MS plaques. +circRNA target 35758280 hsa-mir-889 Osteosarcoma Besides, circ_0078767 positively regulated KLF9 expression in OS cells via repressing miR-889. In conclusion, circ_0078767 enhances KLF9 expression by targeting miR-889 to inhibit OS progression. +genetics_knock down_promote 35758158 hsa-mir-380 Pancreatic Carcinoma Next, the gain and loss-of-function experiments verified that knockdown of miR +lncRNA target 35758024 hsa-mir-31 Osteosarcoma 3p acts as an critical tumor suppressor through inhibiting MGAT1, results in suppressed Wnt/beta-Catenin pathway and decreased proliferation of OS cells; leads to increased apoptosis via Bcl-2/Bax pathway and inhibited migration and invasion ability via the EMT. +genetics_overexpression_promote 35757999 hsa-mir-124a Uveal melanoma Additionally, overexpression of miR-124a in UM cells diminished NSUN2 expression levels indicating that it is an upstream regulator of this response. +other 35757507 hsa-mir-7 Osteoarthritis MiR-7 has been recognized as an osteoarthritis (OA-)-promoting factor, but the specific downstream pathway of miR-7 still remains unknown. Further investigation of the molecular regulatory mechanism of miR-7 might help develop a novel therapeutic method for OA. +lncRNA target 35756932 hsa-mir-23b Cardiomyopathies hsa-miR-23a-3p, hsa-miR-3175, and hsa-miR-23b-3p can regulate the progression of SIC through the regulation of HDAC7/ACTN4. CONCLUSION: : hsa-miR-23a-3p, hsa-miR-3175, and hsa-miR-23b-3p are involved in SIC progression by regulating NF-kappaB signaling signaling pathway-related HDAC7/ACTN4 in monocytes and cardiac tissue cells. +lncRNA target 35756932 hsa-mir-3175 Sepsis hsa-miR-23a-3p, hsa-miR-3175, and hsa-miR-23b-3p can regulate the progression of SIC through the regulation of HDAC7/ACTN4. CONCLUSION: : hsa-miR-23a-3p, hsa-miR-3175, and hsa-miR-23b-3p are involved in SIC progression by regulating NF-kappaB signaling signaling pathway-related HDAC7/ACTN4 in monocytes and cardiac tissue cells. +lncRNA target 35756932 hsa-mir-23b Sepsis hsa-miR-23a-3p, hsa-miR-3175, and hsa-miR-23b-3p can regulate the progression of SIC through the regulation of HDAC7/ACTN4. CONCLUSION: : hsa-miR-23a-3p, hsa-miR-3175, and hsa-miR-23b-3p are involved in SIC progression by regulating NF-kappaB signaling signaling pathway-related HDAC7/ACTN4 in monocytes and cardiac tissue cells. +lncRNA target 35756932 hsa-mir-3175 Cardiomyopathies hsa-miR-23a-3p, hsa-miR-3175, and hsa-miR-23b-3p can regulate the progression of SIC through the regulation of HDAC7/ACTN4. CONCLUSION: : hsa-miR-23a-3p, hsa-miR-3175, and hsa-miR-23b-3p are involved in SIC progression by regulating NF-kappaB signaling signaling pathway-related HDAC7/ACTN4 in monocytes and cardiac tissue cells. +lncRNA target 35756932 hsa-mir-23a Cardiomyopathies hsa-miR-23a-3p, hsa-miR-3175, and hsa-miR-23b-3p can regulate the progression of SIC through the regulation of HDAC7/ACTN4. CONCLUSION: : hsa-miR-23a-3p, hsa-miR-3175, and hsa-miR-23b-3p are involved in SIC progression by regulating NF-kappaB signaling signaling pathway-related HDAC7/ACTN4 in monocytes and cardiac tissue cells. +lncRNA target 35756932 hsa-mir-23a Sepsis hsa-miR-23a-3p, hsa-miR-3175, and hsa-miR-23b-3p can regulate the progression of SIC through the regulation of HDAC7/ACTN4. CONCLUSION: : hsa-miR-23a-3p, hsa-miR-3175, and hsa-miR-23b-3p are involved in SIC progression by regulating NF-kappaB signaling signaling pathway-related HDAC7/ACTN4 in monocytes and cardiac tissue cells. +transcription factor target 35756810 hsa-mir-125b Squamous Cell Carcinoma of Head and Neck CONCLUSION: These findings indicate that miR-21 and miR-125b, associated with the 10 hub genes, jointly participate in OSCC tumorigenesis, offering insight into the molecular mechanisms underlying OSCC as potential targets for early diagnosis, treatment and prognosis. +transcription factor target 35756810 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck CONCLUSION: These findings indicate that miR-21 and miR-125b, associated with the 10 hub genes, jointly participate in OSCC tumorigenesis, offering insight into the molecular mechanisms underlying OSCC as potential targets for early diagnosis, treatment and prognosis. +lncRNA target 35756803 hsa-mir-21 Fibrosis MicroRNA-21 (miR-21) is a well-known fibrosis non-coding RNA, and its role in the development of OSF remains largely unclear. CONCLUSION: Our results suggest that the miR-21/PDCD4 axis mediates the myofibroblast activation of BMFs, and targeting this axis may exert an anti-fibrosis effect. +other 35756803 hsa-mir-21 Opitz GBBB Syndrome, X-Linked MicroRNA-21 (miR-21) is a well-known fibrosis non-coding RNA, and its role in the development of OSF remains largely unclear. We showed the expression of PDCD4 was downregulated in OSF specimens and negatively correlated with miR-21. +other 35756791 hsa-mir-375 Squamous Cell Carcinoma of Head and Neck The detection of miR-372 and miR-375 expression using cytobrush samples may assist in differentiating between OPMD and OSCC. +other 35756787 hsa-mir-760 Oral Submucous Fibrosis RESULTS: NEAT1 and Tropomyosin-1 (TPM1) were significantly increased in OSF specimens, but miR-760 was decreased. +other 35756782 hsa-mir-375 Squamous Cell Carcinoma of Head and Neck CONCLUSION: Our results indicate the potential application of salivary miR-375 as a biomarker for the detection and long-term follow-up of OPMD. +other 35756773 hsa-mir-1 Squamous Cell Carcinoma of Head and Neck This study addressed whether frequent miR-31 and MIR31HG co-upregulation occurred in oral squamous cell carcinoma (OSCC) and its clinical implications. +circulation_biomarker_diagnosis_up 35756772 hsa-mir-223 Diabetes, Gestational targeted messenger RNA (mRNA) expression levels in GCB compared to peripheral blood (PB). +circulation_biomarker_diagnosis_up 35756772 hsa-mir-223 Periodontitis targeted messenger RNA (mRNA) expression levels in GCB compared to peripheral blood (PB). +lncRNA target 35756764 hsa-mir-509 Squamous Cell Carcinoma of Head and Neck CONCLUSION: Our results suggest that the miR-509/plk1 axis may mediate the cancer stemness in oral cancer, and targeting this axis may attenuate the progression of oral cancer. +genetics_knock down_promote 35756756 hsa-mir-1266 Mouth Neoplasms The phenotypic assays including proliferation activity, migration capacity, invasion, wound healing, and colony-forming abilities were conducted in oral cancer cells after knockdown of miR +lncRNA target 35756697 hsa-mir-877 Lung Neoplasms 5p inhibited cell progression by directly targeting FOXM1, which may provide potential biomarkers for targeted therapy of NSCLC. +lncRNA target 35756672 hsa-mir-183 Nasopharyngeal Carcinoma We concluded that OIP5-AS1 performed its biological functions via targeting miR +other 35756646 hsa-mir-411 Thyroid Neoplasms 5p were significantly decreased in tumor tissues compared with normal tissues in THCA. +other 35756646 hsa-mir-299 Thyroid Neoplasms 5p were significantly decreased in tumor tissues compared with normal tissues in THCA. +other 35756646 hsa-mir-410 Thyroid Neoplasms 5p were significantly decreased in tumor tissues compared with normal tissues in THCA. +genetics_overexpression_promote 35756606 hsa-mir-4800 Carcinoma, Hepatocellular 3p was overexpressed in HCC cells. +lncRNA target 35756415 hsa-mir-9 Squamous Cell Carcinoma of Head and Neck The LINC01116-miRMMP1 axis provides a novel insight into the OSCC pathogenesis and offers potential therapeutic targets against OSCC. +lncRNA target 35756165 hsa-mir-204 Melanoma 5p in melanoma metastasis target organs could be used to develop novel approaches for the treatment of disseminated forms of the disease. +genetics_GWAS 35756164 hsa-mir-146a Lupus Erythematosus, Systemic mir-146a genetic polymorphisms in systemic lupus erythematosus patients: This study aimed to investigate the genetic polymorphisms of miR-146a SNPs (rs2910164, rs57095329, and rs2431697) in systemic lupus erythematosus (SLE) patients and their association with clinical manifestations. +target gene 35756081 hsa-mir-450b Colorectal Neoplasms Long Intergenic Noncoding RNA 00641 Promotes Growth and Invasion of Colorectal Cancer through Regulating miR-450b-5p/GOLPH3 Axis. +genetics_GWAS 35756079 hsa-mir-373 Osteoarthritis Taken together, our study showed that CREB alleviates OA injury through regulating the expression of miR-373, which directly targeted METTL3, and finally relieved TFEB from METTL3-mediated epigenetic suppression. The CREB/miR-373/METTL3/TFEB axis may be used as a potential target for the treatment of OA. +circulation_biomarker_diagnosis_ns 35755441 hsa-mir-200a Adenocarcinoma in Situ miR-200a-3p expression in the serum MV and platelets had increased to 1.41 (p < 0.05) and 3.29 times (p < 0.001), respectively, in AIS patients compared with healthy controls, and was modified by severity of AIS. Our results presented new evidence that activated platelets could remotely modulate ET-1 and VEGFA expression in HUVEC via releasing miR-200a-3p-enriched PMVs, which provides a potential miRNA-based predictive biomarker and therapeutic strategy for atherosclerosis and AIS. +other 35754188 hsa-mir-203 Burns Both MVs and PRP significantly downregulated gene expression of miRNA-203 & alphaSMA and immunoblotting analysis of MMP-3 and TGF-beta compared with the burn group. +genetics_knock down_suppress 35754140 hsa-mir-145 Keloid CONCLUSION: Hsa_circ_0043688 knockdown inhibited cell growth and metastasis of keloid fibroblasts via miR +other 35754121 hsa-mir-21 Dermatitis, Atopic 5p (R = .20, p = .022). +other 35754121 hsa-mir-375 Dermatitis, Atopic 5p (R = .20, p = .022). +transcription factor target 35753437 hsa-mir-142 Breast Neoplasms 3p inhibited migration, invasion and metastatic potential of breast cancer cells. +other 35753367 hsa-mir-124 Stress Disorders, Post-Traumatic BACKGROUND: MicroRNA3p (miR-124) plays an important role in neuroprotective functions in various neurological disorders, but whether miR-124 participates in the pathological progression of posttraumatic stress disorder (PTSD) remains poorly understood. +lncRNA target 35753017 hsa-mir-145 Muscular Diseases Taken together, we concluded that miR5p promoted cell death to facilitate muscle dysfunctions via inactivating the PI3K/Akt/mTOR pathway. +genetics_overexpression_promote 35752700 hsa-mir-7 Arthritis, Rheumatoid Finally, we overexpressed miR-7 in RA-FLS and discovered that miR-7 inhibited RA-FLS hyperproliferation, migration, invasion, and apoptosis, whereas ciRS-7 overexpression reversed these effects. +circulation_biomarker_diagnosis_up 35752392 hsa-mir-29c Cognition Disorders CONCLUSION: The plasma NCAM/amphiphysin 1 dual-labeled exosomal miR-29c-3p had potential advantages in the diagnosis of SCD. +exosome 35751950 hsa-mir-3681 ST Elevation Myocardial Infarction Exosomal miR +exosome 35751950 hsa-mir-152 ST Elevation Myocardial Infarction Exosomal miR +other 35751896 hsa-mir-489 Carcinoma, Non-Small-Cell Lung 3p in lung carcinoma may be the key to the earlier diagnosis and treatment of lung carcinoma. +transcription factor target 35751784 hsa-mir-326 Uterine Cervical Neoplasms Upregulation of miR-326 decreased SMO expression and its downstream proteins but does not affect the proliferation of CSCC cells. The upregulation of miR-326 increased radiation sensitivity of the CSCC cell through downregulating SMO and its downstream proteins in the Hedgehog (Hh) signaling pathway. +other 35751569 hsa-mir-146a Pre-Eclampsia CONCLUSION: The expression of miR-146a decreased in severe PE and was negatively correlated with SMAD4 expression. +other 35751015 hsa-mir-145 Coronary Artery Disease The ROC curve analysis indicated that miR-145, miR-182, miR-133a and, miR-205 were excellent biomarkers with the highest AUCs as biomarkers in CAD. +other 35751015 hsa-mir-126 Coronary Artery Disease MiR-126 and miR-155 showed significance with BMI grade, while only miR-133a showed significance with the obese patients in general. +other 35751015 hsa-mir-133a Coronary Artery Disease The ROC curve analysis indicated that miR-145, miR-182, miR-133a and, miR-205 were excellent biomarkers with the highest AUCs as biomarkers in CAD. +other 35751015 hsa-mir-205 Coronary Artery Disease The ROC curve analysis indicated that miR-145, miR-182, miR-133a and, miR-205 were excellent biomarkers with the highest AUCs as biomarkers in CAD. +other 35751015 hsa-mir-182 Coronary Artery Disease The ROC curve analysis indicated that miR-145, miR-182, miR-133a and, miR-205 were excellent biomarkers with the highest AUCs as biomarkers in CAD. +other 35751015 hsa-mir-155 Coronary Artery Disease MiR-126 and miR-155 showed significance with BMI grade, while only miR-133a showed significance with the obese patients in general. +other 35750202 hsa-mir-145 Spinal Cord Injuries Further studies are needed to investigate the potential interplay between Nrf2 and miRNA145-5p in neuroinflammatory condition. +other 35750139 hsa-mir-582 Biliary Tract Neoplasms 3p) were identified and validated as diagnostic of BTC on univariable analysis. +other 35750139 hsa-mir-145 Biliary Tract Neoplasms 3p) were identified and validated as diagnostic of BTC on univariable analysis. +other 35750139 hsa-mir-92b Biliary Tract Neoplasms 3p) were identified and validated as diagnostic of BTC on univariable analysis. +other 35750139 hsa-let-7a Biliary Tract Neoplasms 3p) were identified and validated as diagnostic of BTC on univariable analysis. +other 35750046 hsa-mir-139 Amyotrophic Lateral Sclerosis We identify the downregulation of miR-139, an MN-enriched microRNA, in FUS and sporadic ALS MN. We discover that miR-139 downregulation leads to the activation of canonical WNT signaling and demonstrate that the WNT transcriptional mediator beta-catenin is a major driver of MN degeneration in ALS. +genetics_overexpression_promote 35749939 hsa-mir-651 Ovarian Neoplasms 3p was overexpressed and downregulated to study the functional changes in ovarian cancer cells. +other 35749917 hsa-mir-200a uterine corpus endometrial carcinoma OBJECTIVE: In this study, we focused on five microRNAs (miRNAs) that have been reported to regulate phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene expression, namely miR-182, miR-183, miR-200a, miR-200b, and miR-205, and examined their relationships with PTEN protein expression in endometrial cancer tissues. CONCLUSION: Using endometrial cancer tissues, we found for the first time that miR-182, miR-183, miR-200a, and miR-200b were strongly correlated with each other, whereas miR-205 was not strongly correlated with the other four miRNAs. +other 35749917 hsa-mir-183 uterine corpus endometrial carcinoma OBJECTIVE: In this study, we focused on five microRNAs (miRNAs) that have been reported to regulate phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene expression, namely miR-182, miR-183, miR-200a, miR-200b, and miR-205, and examined their relationships with PTEN protein expression in endometrial cancer tissues. CONCLUSION: Using endometrial cancer tissues, we found for the first time that miR-182, miR-183, miR-200a, and miR-200b were strongly correlated with each other, whereas miR-205 was not strongly correlated with the other four miRNAs. +other 35749917 hsa-mir-182 uterine corpus endometrial carcinoma OBJECTIVE: In this study, we focused on five microRNAs (miRNAs) that have been reported to regulate phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene expression, namely miR-182, miR-183, miR-200a, miR-200b, and miR-205, and examined their relationships with PTEN protein expression in endometrial cancer tissues. CONCLUSION: Using endometrial cancer tissues, we found for the first time that miR-182, miR-183, miR-200a, and miR-200b were strongly correlated with each other, whereas miR-205 was not strongly correlated with the other four miRNAs. +other 35749917 hsa-mir-205 uterine corpus endometrial carcinoma OBJECTIVE: In this study, we focused on five microRNAs (miRNAs) that have been reported to regulate phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene expression, namely miR-182, miR-183, miR-200a, miR-200b, and miR-205, and examined their relationships with PTEN protein expression in endometrial cancer tissues. CONCLUSION: Using endometrial cancer tissues, we found for the first time that miR-182, miR-183, miR-200a, and miR-200b were strongly correlated with each other, whereas miR-205 was not strongly correlated with the other four miRNAs. +other 35749917 hsa-mir-200b uterine corpus endometrial carcinoma OBJECTIVE: In this study, we focused on five microRNAs (miRNAs) that have been reported to regulate phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene expression, namely miR-182, miR-183, miR-200a, miR-200b, and miR-205, and examined their relationships with PTEN protein expression in endometrial cancer tissues. CONCLUSION: Using endometrial cancer tissues, we found for the first time that miR-182, miR-183, miR-200a, and miR-200b were strongly correlated with each other, whereas miR-205 was not strongly correlated with the other four miRNAs. +circulation_biomarker_diagnosis_ns 35749663 hsa-mir-145 Bipolar Disorder CONCLUSION: Differential expression of five miRNAs in peripheral blood may be associated with the pathogenesis of BD-I, and hsa-miR +genetics_knock down_suppress 35748916 hsa-mir-630 Carcinoma, Non-Small-Cell Lung CONCLUSION: CircDLG1 knockdown could impede NSCLC advancement through modulating the miR-630/CENPF axis, manifesting as a promising molecular target for NSCLC treatment. +lncRNA target 35748914 hsa-mir-4268 Stomach Neoplasms Collectively, our present results indicate that the miR-4268/KRT80 axis acts as a potential therapeutic target for patients with GC.Abbreviations: Gastric cancer (GC); MicroRNAs (miRNAs); Keratin 80 (KRT80); differentially expressed genes (DEGs); chemoradiotherapy (CRT); negative nonsense sequence (NC); radioimmunoprecipitation assay (RIPA); polyvinylidene fluoride (PVDF). +lncRNA target 35748489 hsa-mir-485 Carcinoma, Hepatocellular 5p or upregulation of LSM4 reversed the inhibition of HCC cell malignant behavior by LINC01419 interference. +other 35748299 hsa-mir-637 Stomach Neoplasms Circ_0017274 downregulation boosted CDDP sensitivity by acting on miR-637/CDX2 in CDDP-resistant GC cells. +other 35748251 hsa-mir-4463 Arteriosclerosis Obliterans BACKGROUND: Our previous study revealed aberrant miR-4463 expression in the vascular tissues of patients with arteriosclerosis obliterans of the lower extremities (ASO), but the role of miR-4463 was largely ambiguous. +other 35748251 hsa-mir-4463 Osteoarthritis BACKGROUND: Our previous study revealed aberrant miR-4463 expression in the vascular tissues of patients with arteriosclerosis obliterans of the lower extremities (ASO), but the role of miR-4463 was largely ambiguous. +transcription factor target 35748251 hsa-mir-4463 Ischemia Inhibition of miR-4463 might be a potential strategy to protect endothelial cells and maintain vascular function in patients with lower limb ischemia and its complications. +genetics_knock down_promote 35747966 hsa-mir-433 Carcinoma, Non-Small-Cell Lung 3p knockdown or GRB2 overexpression counteracted the repressive effect of LINC01234 silencing on NSCLC cell malignant proliferation. +circRNA target 35747942 hsa-mir-19a Carcinoma, Hepatocellular In addition, circ_0001649 suppressed the development of sevoflurane-induced HCC cells through miR-19a-3p/SGTB axis. CONCLUSION: Our study demonstrated that sevoflurane inhibited HCC cell development via circ_0001649/miR-19a-3p/SGTB axis. +circulation_biomarker_diagnosis_up 35747760 hsa-mir-124 Polycystic Ovary Syndrome 3p expression in the serum of obese and nonobese PCOS patients. +lncRNA target 35747689 hsa-mir-152 Stomach Neoplasms CONCLUSION: AG can decrease GC multiplication, clone formation and migration and induce apoptosis via modulating circKIF4A/miR +lncRNA target 35747602 hsa-mir-4298 Keratoconus Overall, we uncovered a hub ceRNA network that might underlie a critical posttranslational regulatory mechanism in KC, in which miR-4257, miR-4494, miR-4263, and miR-4298 could be valuable biomarkers and provided core RNAs therapeutic targets for KC. +lncRNA target 35747602 hsa-mir-4494 Keratoconus Overall, we uncovered a hub ceRNA network that might underlie a critical posttranslational regulatory mechanism in KC, in which miR-4257, miR-4494, miR-4263, and miR-4298 could be valuable biomarkers and provided core RNAs therapeutic targets for KC. +lncRNA target 35747602 hsa-mir-4263 Keratoconus Overall, we uncovered a hub ceRNA network that might underlie a critical posttranslational regulatory mechanism in KC, in which miR-4257, miR-4494, miR-4263, and miR-4298 could be valuable biomarkers and provided core RNAs therapeutic targets for KC. +lncRNA target 35747602 hsa-mir-4257 Keratoconus Overall, we uncovered a hub ceRNA network that might underlie a critical posttranslational regulatory mechanism in KC, in which miR-4257, miR-4494, miR-4263, and miR-4298 could be valuable biomarkers and provided core RNAs therapeutic targets for KC. +other 35747400 hsa-mir-542 Osteosarcoma circ-RANGAP1/MicroRNA-542-3p/Myosin Regulatory Light Chain Interacting Protein Axis Modulates the Osteosarcoma Cell Progression. +virus_miRNA 35746694 hbv-mir-6 Hepatitis B, Chronic HBV-miR-6 may play a role in the process of viral excretion or particle formation in vivo. +genetics_overexpression_promote 35745075 hsa-mir-21 ovarian clear cell carcinoma Functional analyses indicated that miR-21 overexpressed in CCCO cells targeted tumor suppressor genes PTEN, TPM1, PDCD4, and MASP1. +other 35743776 hsa-mir-29b Breast Neoplasms These findings may contribute to better classify breast tumors having the triple negative phenotype, and suggest that the activation of the Vav1/miR-29b axis, precisely regulating the amount of an Akt isozyme crucial for tumor dissemination, could have great potential for driving more accurate therapies to TNBCs, often not eligible or resistant to treatments. +lncRNA target 35743464 hsa-mir-376a Tuberous Sclerosis 1 Upregulation of miR-136, miR-376a-3p, and miR5p was noted in TSC patients treated with mTOR inhibitors, indicating a role in the downregulation of the mTOR pathway. +lncRNA target 35743464 hsa-mir-150 Tuberous Sclerosis 1 Upregulation of miR-136, miR-376a-3p, and miR5p was noted in TSC patients treated with mTOR inhibitors, indicating a role in the downregulation of the mTOR pathway. +lncRNA target 35743464 hsa-mir-136 Tuberous Sclerosis 1 Upregulation of miR-136, miR-376a-3p, and miR5p was noted in TSC patients treated with mTOR inhibitors, indicating a role in the downregulation of the mTOR pathway. +other 35743416 hsa-mir-155 Gastritis Dynamic evaluation of miR-155 might enlighten its prognostic role in pediatric gastritis. +other 35743416 hsa-mir-155 Gastritis, Pediatric Dynamic evaluation of miR-155 might enlighten its prognostic role in pediatric gastritis. +other 35743308 hsa-mir-92a Dermatitis, Atopic The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492). +other 35743308 hsa-mir-4492 Dermatitis, Atopic The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492). +other 35743308 hsa-let-7i Alzheimer Disease The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492). +other 35743308 hsa-mir-146a Dermatitis, Atopic The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492). +other 35743308 hsa-mir-4497 Alzheimer Disease The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492). +other 35743308 hsa-mir-4497 Dermatitis, Atopic The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492). +other 35743308 hsa-mir-92a Alzheimer Disease The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492). +other 35743308 hsa-mir-342 Dermatitis, Atopic The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492). +other 35743308 hsa-mir-4492 Alzheimer Disease The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492). +other 35743308 hsa-mir-146a Alzheimer Disease The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492). +other 35743308 hsa-mir-181b Dermatitis, Atopic The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492). +other 35743308 hsa-mir-26a Alzheimer Disease The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492). +other 35743308 hsa-mir-26a Dermatitis, Atopic The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492). +other 35743308 hsa-mir-181b Alzheimer Disease The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492). +other 35743308 hsa-mir-148a Alzheimer Disease The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492). +other 35743308 hsa-mir-148a Dermatitis, Atopic The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492). +other 35743308 hsa-let-7i Dermatitis, Atopic The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492). +other 35743308 hsa-mir-342 Alzheimer Disease The small RNA-seq analysis identified ten mature miRNAs that were modulated by AD IgG compared to mock condition (miR-181b-5p, hsa-miR-130b-3p, hsa-miR-26a-5p, hsa-miR-4497, has-miR-146a, hsa-let-7i-5p, hsa-miR3p, has-miR-148a-3p, has-miR-92a and has-miR-4492). +lncRNA target 35743223 hsa-mir-149 Lung Neoplasms 5p, cyclin D1, and forkhead box protein M1 (FOXM1) expression analysis via qPCR. +epigenetics 35743167 hsa-mir-155 Leukemia In this work, we show that combinatorial treatment of acute myeloid leukemia (AML) cells with DNA methylation inhibitors (5-Azacytidine), MYB inhibitors (Celastrol), and anti-miR-155 (AM155) ideally leads to overproduction of PU.1. +genetics_knock down_promote 35742991 hsa-mir-133a dilated cardiomyopathy 1FF Furthermore, the T3-mediated transcriptional activation of mitoK-ATP in the myocardium and NRCM was associated with the repression of the TH-inactivating enzyme, deiodinase 3 (Dio3), and an up-regulation of the T3-responsive miR-133a-3p. Mechanistically, the loss and gain of function experiments and reporter gene assays performed in NRCM, have revealed a new regulatory axis whereby the silencing of Dio3 under the control of miR-133a-3p drives the T3-dependent modulation of cardiac mitoK and mitoSur transcription. +lncRNA target 35742854 hsa-mir-654 Lung Neoplasms 5p inhibited the lung cancer cell epithelial-mesenchymal transition (EMT) process, cell proliferation, and migration using target-based, abundance-based, and ssGSEA-based bioinformatic methods and in vitro validation. +other 35742854 hsa-mir-654 Syphilis We found that miR5p abundance was significantly elevated in LUAD tissues and correlated with patients' survival. +other 35741700 hsa-mir-29a systemic primary carnitine deficiency disease 5p and miR-23a-5p were downregulated. +other 35741700 hsa-mir-363 Fetal Growth Retardation 5p and miR-23a-5p were downregulated. +other 35741700 hsa-mir-6126 systemic primary carnitine deficiency disease In both SGA-nCU and SGA-CU, miR3p was upregulated and miR-6126 was downregulated. +other 35741700 hsa-mir-29a Alopecia 5p and miR-23a-5p were downregulated. +other 35741700 hsa-mir-29c systemic primary carnitine deficiency disease 5p and miR-23a-5p were downregulated. +other 35741700 hsa-mir-363 Alopecia 5p and miR-23a-5p were downregulated. +other 35741700 hsa-mir-874 Fetal Growth Retardation In both SGA-nCU and SGA-CU, miR3p was upregulated and miR-6126 was downregulated. +other 35741700 hsa-mir-29a Fetal Growth Retardation 5p and miR-23a-5p were downregulated. +other 35741700 hsa-mir-6126 Fetal Growth Retardation In both SGA-nCU and SGA-CU, miR3p was upregulated and miR-6126 was downregulated. +other 35741700 hsa-mir-29c Alopecia 5p and miR-23a-5p were downregulated. +other 35741700 hsa-mir-874 systemic primary carnitine deficiency disease In both SGA-nCU and SGA-CU, miR3p was upregulated and miR-6126 was downregulated. +other 35741700 hsa-mir-23a Alopecia 5p and miR-23a-5p were downregulated. +other 35741700 hsa-mir-23a systemic primary carnitine deficiency disease 5p and miR-23a-5p were downregulated. +other 35741700 hsa-mir-363 systemic primary carnitine deficiency disease 5p and miR-23a-5p were downregulated. +other 35741700 hsa-mir-23a Fetal Growth Retardation 5p and miR-23a-5p were downregulated. +other 35741700 hsa-mir-29c Fetal Growth Retardation 5p and miR-23a-5p were downregulated. +other 35741665 hsa-mir-30 Glaucoma RESULTS: circXPO5 significantly decreased in the glaucoma model and a ceRNA network analysis revealed that circXPO5 can bind to miR5p, which also binds to GRIN2A (ionotropic receptor NMDA type subunit 2A). +other 35741223 hsa-let-7 Colorectal Neoplasms Exo-Let7, exo-miR-16 and exo-miR-23 significantly differed between CRC and healthy controls (all p < 0.05), while no c-miR showed this potential. +other 35741223 hsa-mir-16 Colorectal Neoplasms Exo-Let7, exo-miR-16 and exo-miR-23 significantly differed between CRC and healthy controls (all p < 0.05), while no c-miR showed this potential. +other 35741223 hsa-mir-23 Colorectal Neoplasms Exo-Let7, exo-miR-16 and exo-miR-23 significantly differed between CRC and healthy controls (all p < 0.05), while no c-miR showed this potential. +other 35741194 hsa-mir-4324 Thyroid Cancer, Papillary This prospective study showed that the expression analysis of four miRNAs (miR125A, miR146B, miR221, and miR4324) improve accuracy of FNAB, which could allow a better pre-operative diagnostic and prognostic assessment of thyroid malignancies. +other 35741194 hsa-mir-221 Thyroid Cancer, Papillary This prospective study showed that the expression analysis of four miRNAs (miR125A, miR146B, miR221, and miR4324) improve accuracy of FNAB, which could allow a better pre-operative diagnostic and prognostic assessment of thyroid malignancies. +other 35741194 hsa-mir-125a Thyroid Cancer, Papillary This prospective study showed that the expression analysis of four miRNAs (miR125A, miR146B, miR221, and miR4324) improve accuracy of FNAB, which could allow a better pre-operative diagnostic and prognostic assessment of thyroid malignancies. +other 35741194 hsa-mir-146b Thyroid Cancer, Papillary This prospective study showed that the expression analysis of four miRNAs (miR125A, miR146B, miR221, and miR4324) improve accuracy of FNAB, which could allow a better pre-operative diagnostic and prognostic assessment of thyroid malignancies. +epigenetics 35741046 hsa-mir-10b Sarcoidosis Thus, the aim of the study was to investigate the methylation pattern of gene bodies of chosen miRNAs identified in sarcoid tissue (miR-101, miR-10b, miR-200a, and miR +epigenetics 35741046 hsa-mir-101-1 Sarcoidosis Thus, the aim of the study was to investigate the methylation pattern of gene bodies of chosen miRNAs identified in sarcoid tissue (miR-101, miR-10b, miR-200a, and miR +epigenetics 35741046 hsa-mir-200a Sarcoidosis Thus, the aim of the study was to investigate the methylation pattern of gene bodies of chosen miRNAs identified in sarcoid tissue (miR-101, miR-10b, miR-200a, and miR3p), which have also been established to play roles in neoplastic transformation. +epigenetics 35741046 hsa-mir-338 Sarcoidosis Thus, the aim of the study was to investigate the methylation pattern of gene bodies of chosen miRNAs identified in sarcoid tissue (miR-101, miR-10b, miR-200a, and miR3p), which have also been established to play roles in neoplastic transformation. +epigenetics 35741046 hsa-mir-101 Sarcoidosis Thus, the aim of the study was to investigate the methylation pattern of gene bodies of chosen miRNAs identified in sarcoid tissue (miR-101, miR-10b, miR-200a, and miR +other 35740455 hsa-mir-141 Colorectal Neoplasms The fluorescein isothiocyanate (FITC) probe and biotinylated probe are designed for a two-pronged approach to the detection of the urinary miR-21 and miR-141, both of which have demonstrated significance in the development and progression of colorectal cancer, a leading cause of mortality and morbidity. +other 35740455 hsa-mir-21 Colorectal Neoplasms The fluorescein isothiocyanate (FITC) probe and biotinylated probe are designed for a two-pronged approach to the detection of the urinary miR-21 and miR-141, both of which have demonstrated significance in the development and progression of colorectal cancer, a leading cause of mortality and morbidity. +other 35740420 hsa-mir-17 CREST Syndrome 5p. +other 35740420 hsa-mir-17 Chronic Rhinosinusitis With Nasal Polyps 5p. +other 35740420 hsa-mir-203a CREST Syndrome 5p. +other 35740420 hsa-mir-145 Chronic Rhinosinusitis With Nasal Polyps 5p. +other 35740420 hsa-mir-145 CREST Syndrome 5p. +other 35740420 hsa-mir-203a Chronic Rhinosinusitis With Nasal Polyps 5p. +other 35740375 hsa-mir-133a Myocardial Infarction Moreover, we assessed a known myocardial infarction-related miR-133a in acute myocardial infarct patients vs. healthy subjects. +circulation_biomarker_prognosis_ns 35740344 hsa-mir-20a Lymphoma, Non-Hodgkin Moreover, hsa-miR-20a-5p/SNHG16 and hsa-miR-181a-5p/SNHG6 pairs' plasma levels were associated with overall survival and progression-free survival of NHL patients, being independent prognostic factors in a multivariate Cox analysis. +circulation_biomarker_prognosis_ns 35740344 hsa-mir-181a Lymphoma, Non-Hodgkin Moreover, hsa-miR-20a-5p/SNHG16 and hsa-miR-181a-5p/SNHG6 pairs' plasma levels were associated with overall survival and progression-free survival of NHL patients, being independent prognostic factors in a multivariate Cox analysis. +other 35740327 hsa-mir-381 Ovarian Neoplasms 3p) had expressed trend concordance between breast, ovarian, and endometrium cancer cell lines compared with normal lines, confirming our in silico predictions. +other 35740327 hsa-mir-31 Ovarian Neoplasms 3p) had expressed trend concordance between breast, ovarian, and endometrium cancer cell lines compared with normal lines, confirming our in silico predictions. +other 35740327 hsa-mir-23a Ovarian Neoplasms 3p) had expressed trend concordance between breast, ovarian, and endometrium cancer cell lines compared with normal lines, confirming our in silico predictions. +other 35740327 hsa-mir-23b Ovarian Neoplasms 3p) had expressed trend concordance between breast, ovarian, and endometrium cancer cell lines compared with normal lines, confirming our in silico predictions. +transcription factor target 35740314 hsa-mir-222 Obesity The WD group also presented lower expression of Insig1 (miR-26a's target) and Cxcr4 (miR-222's target) than the Rev group. +other 35740034 hsa-mir-181b Diabetes Mellitus, Type 2 The current study aimed to investigate whether miR-181b ameliorates diabetes-associated endothelial dysfunction, and to identify potential molecular mechanisms and upstream inducer of miR-181b. Overall, our findings highlight a critical role of AMPK/miR-181b axis and extend the benefits of chronic exercise in counteracting diabetes-associated endothelial dysfunction. +other 35740034 hsa-mir-181b Endothelial Dysfunction The current study aimed to investigate whether miR-181b ameliorates diabetes-associated endothelial dysfunction, and to identify potential molecular mechanisms and upstream inducer of miR-181b. Overall, our findings highlight a critical role of AMPK/miR-181b axis and extend the benefits of chronic exercise in counteracting diabetes-associated endothelial dysfunction. +other 35740034 hsa-mir-181b Acute Lung Injury The current study aimed to investigate whether miR-181b ameliorates diabetes-associated endothelial dysfunction, and to identify potential molecular mechanisms and upstream inducer of miR-181b. Overall, our findings highlight a critical role of AMPK/miR-181b axis and extend the benefits of chronic exercise in counteracting diabetes-associated endothelial dysfunction. +genetics_overexpression_promote 35738798 hsa-mir-21 Melanoma 3p overexpression in tumor synergized with anti-PD-1 antibody by promoting tumor cell ferroptosis. +other 35738418 hsa-mir-183 Subarachnoid Hemorrhage 5p/TCF7L2 signaling axis to attenuate neurological deficit and endothelial dysfunction after SAH. +other 35738418 hsa-mir-183 Endothelial Dysfunction 5p/TCF7L2 signaling axis to attenuate neurological deficit and endothelial dysfunction after SAH. +circulation_biomarker_diagnosis_down 35737431 hsa-mir-361 Abortion, Habitual Our results showed that the expression of BCL-2 and lncRNA SRA was significantly higher in the blood samples of RPL patients than in controls, while the expression of miR +circRNA target 35736860 hsa-mir-106b limb ischemia CONCLUSION: All these findings suggested that RSV acted as an inhibitory factor in ox-LDL-induced endothelial injury via downregulating circ_0091822 to upregulate miR-106b-5p-related TLR4. +circRNA target 35736860 hsa-mir-106b Atherosclerosis CONCLUSION: All these findings suggested that RSV acted as an inhibitory factor in ox-LDL-induced endothelial injury via downregulating circ_0091822 to upregulate miR-106b-5p-related TLR4. +other 35735607 hsa-mir-92a-2 Autism Spectrum Disorde Our results suggest that miR-92a5p is a strong risk factor for ASD and potentially contributes to neuropsychiatric disorders. +other 35735454 hsa-mir-10a Glioblastoma Our 3-microRNA signature (hsa-miR-20a, hsa-miR-21, hsa-miR-10a) may further empower glioblastoma multiforme prognostic evaluation in clinical practice and enrich drug repurposing pipelines. +genetics_overexpression_promote 35735238 hsa-mir-24 Influenza, Human 5p overexpression attenuates IAV-associated necroptosis and enhances viral replication, whereas deletion of miR +other 35735229 hsa-mir-24 Pre-Eclampsia 3p to regulate HSD11B2; thereby, the growth of placental trophoblasts is promoted in PE. +other 35735115 hsa-mir-27a Carcinoma, Renal Cell Moreover, we determined that the AC093157.1/miR-27a-3p axis can potentially regulate ZNF268 function in ccRCC. +lncRNA target 35735114 hsa-mir-410 Inflammatory Bowel Diseases In addition, microRNA3p was remarkedly suppressed in IECs from UC patients. +transcription factor target 35735031 hsa-mir-29b Atherosclerosis In conclusion, this study reveals that the Lss-sensitive miR-29b-3p/CX3CL1 axis is an important regulatory target that affects vascular endothelial inflammation and AS development. +transcription factor target 35734966 hsa-mir-221 Breast Neoplasms 3 in HER2-positive breast cancer contributes to cancer cell proliferation and migration by directly targeting the tumor suppressors LASS2 and MBD2. +other 35734958 hsa-mir-143 Metabolic Diseases Thus, betaine and miR-143 function together as key regulators and biomarkers for preventing and diagnosing metabolic diseases such as fatty liver disease, obesity, and diabetes. +other 35734958 hsa-mir-143 Fatty Liver Thus, betaine and miR-143 function together as key regulators and biomarkers for preventing and diagnosing metabolic diseases such as fatty liver disease, obesity, and diabetes. +other 35734958 hsa-mir-143 Diabetes Mellitus Thus, betaine and miR-143 function together as key regulators and biomarkers for preventing and diagnosing metabolic diseases such as fatty liver disease, obesity, and diabetes. +other 35734958 hsa-mir-143 Obesity Thus, betaine and miR-143 function together as key regulators and biomarkers for preventing and diagnosing metabolic diseases such as fatty liver disease, obesity, and diabetes. +circulation_biomarker_diagnosis_up 35734774 hsa-mir-451 Pulmonary Arterial Hypertension CONCLUSIONS: Children with CHD-PAH can be diagnosed based on aberrant expressions of miR-204 and miR-451 in their peripheral blood serum. +circulation_biomarker_diagnosis_up 35734774 hsa-mir-451 Heart Diseases, Congenital CONCLUSIONS: Children with CHD-PAH can be diagnosed based on aberrant expressions of miR-204 and miR-451 in their peripheral blood serum. +circulation_biomarker_diagnosis_up 35734774 hsa-mir-204 Pulmonary Arterial Hypertension CONCLUSIONS: Children with CHD-PAH can be diagnosed based on aberrant expressions of miR-204 and miR-451 in their peripheral blood serum. +circulation_biomarker_diagnosis_up 35734774 hsa-mir-204 Heart Diseases, Congenital CONCLUSIONS: Children with CHD-PAH can be diagnosed based on aberrant expressions of miR-204 and miR-451 in their peripheral blood serum. +circRNA target 35733856 hsa-mir-93 Diabetic Nephropathies CONCLUSION: Circ_0004951 promotes pyroptosis of renal tubular epithelial cells in DKD via the miR5p/NLRP3 inflammasome pathway, suggesting its potential for clinical diagnosis and treatment of DKD. +target gene 35733786 hsa-mir-625 Osteosarcoma Circ_0051079 silencing inhibits the malignant phenotypes of osteosarcoma cells by the TRIM66/Wnt/β-catenin pathway in a miR-625-5p-dependent manner. +other 35733784 hsa-mir-20 Lipodystrophy In conclusion, cmiRs-320 constitute novel biomarkers of LD, abundance of miR320a-3p is inversely associated to indicators related to WAT function, while downregulation of cmiR-320d predicts an altered hepatic profile and higher inflammation. +other 35733784 hsa-mir-320d Lipodystrophy In conclusion, cmiRs-320 constitute novel biomarkers of LD, abundance of miR320a-3p is inversely associated to indicators related to WAT function, while downregulation of cmiR-320d predicts an altered hepatic profile and higher inflammation. +other 35733784 hsa-mir-20a Lipodystrophy In conclusion, cmiRs-320 constitute novel biomarkers of LD, abundance of miR320a-3p is inversely associated to indicators related to WAT function, while downregulation of cmiR-320d predicts an altered hepatic profile and higher inflammation. +lncRNA target 35733703 hsa-mir-206 Polycystic Ovary Syndrome Our report was designed to explore whether liquiritin play a role in PCOS by regulating human ovarian granulosa cell-like KGN cells proliferation and apoptosis through miR-206/phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway, and to further elucidate the underlying molecular mechanisms. In conclusion, our findings suggested that liquiritin exerted anti-proliferative and apoptosis-inducing roles in KGN cells via miR-206/PI3K/AKT pathway, suggesting that liquiritin may be an effective therapeutic target for PCOS treatment. +lncRNA target 35733354 hsa-mir-195 Osteoarthritis CONCLUSIONS: Our study is a proof-of-concept demonstration for targeting m6A-modified circRERE and its target miR5p/IRF2BPL/beta-catenin as potential therapeutic strategies for OA treatment. +genetics_knock down_promote 35733309 hsa-mir-626 Carcinoma, Endometrioid Besides, CDKN1B overexpression of miR-626 knockdown reversed the effects of knocking down circ_0000437 on EC cells. +transcription factor target 35733144 hsa-mir-218 Chediak-Higashi Syndrome Interestingly, we identified that CH-SEVs were enriched in miRNA-218 and ITGBL1 protein, which played important roles in promoting fibroblast activity via activation of the downstream TGFbeta1-SMAD2/3 pathway in vitro. +other 35733067 hsa-mir-155 Inflammation MicroRNA(miR)5p is reportedly increased significantly in OLP and is known to regulate inflammation. +genetics_knock down_promote 35733067 hsa-mir-155 Osteoporosis-pseudoglioma syndrome 5p in OLP AFs augmented IL-6 and IL-8 release and decreased SOCS1 expression, whereas knockdown of miR +other 35733067 hsa-mir-155 Osteochondromatosis This study aimed to investigate the role of miR5p in fibroblasts of OLP lesions. +lncRNA target 35732999 hsa-mir-1291 Pancreatic Carcinoma The efficacy of a BioRNA, miR-1291, in the inhibition of pancreatic cancer PDO and PDX growth is exemplified in this chapter. +other 35732605 hsa-mir-28 Cardiomyopathy, Hypertrophic, Familial Methods Real-time quantitative PCR was used to detect the expressions of miR3p, FOXP3, and IL-17 mRNA in FHC colorectal epithelial cells and colorectal cancer cells (HCT116, Caco-2, and LoVo). +other 35732605 hsa-mir-28 Colorectal Neoplasms 3p in colorectal cancer cells decreased, while the levels of FOXP3 and IL-17 increased. +exosome 35732322 hsa-mir-34a Colorectal Neoplasms Re-analysis of published miRNA profiles of CRC tumours or CRC exosomes revealed that only 2 out of 29 miRNAs were up-regulated in all datasets including ours (miR-34a and miR3p). +exosome 35732322 hsa-mir-25 Colorectal Neoplasms Re-analysis of published miRNA profiles of CRC tumours or CRC exosomes revealed that only 2 out of 29 miRNAs were up-regulated in all datasets including ours (miR-34a and miR3p). +lncRNA target 35732230 hsa-mir-155 Osteoarthritis In conclusion, PCB153 could promote the degradation of the extracellular matrix of chondrocytes by upregulating miR-155 via a mechanism related to the activation of the PI3K/Akt/mTOR and RICTOR/Akt/mTOR signaling pathway, which suppressed autophagy and facilitated the development of OA. MiR-155 may represent potential therapeutic targets to alleviate the development of OA. +transcription factor target 35732226 hsa-mir-135 Hepatitis B Immunohistochemical staining and HBV core particle DNA analysis confirmed that HBV replication in the liver was strongly inhibited by AAV8-amiRNA135. +transcription factor target 35732048 hsa-mir-15a Obesity Furthermore, our findings suggested that miR-15a and its target gene(s) might represent new targets for investigating intramuscular fat deposits in cattle and treating human obesity. +lncRNA target 35732008 hsa-mir-34a External Auditory Canal Squamous Cell Carcinoma SIGNIFICANCE: The expression level of miR-34a may predict a prognosis in patients with advanced-stage EACSCC. +other 35731831 hsa-mir-223 Abortion, Spontaneous Moreover, miR-223 was downregulated in the villous tissues of patients with SA and was further predicted and shown to negatively interact with circ-CCNB1, which is involved in trophoblast proliferation and invasion. CONCLUSION: Circ-CCNB1 served as a modulator of trophoblast proliferation and invasion by sponging miR-223, thus forming a regulatory network of circ-CCNB1/miR-223/SIAH1 in modulating CCNB1 nuclear translocation, which enabled us to elucidate the molecular mechanisms involved in normal embryo implantation or in SA. +other 35731638 hsa-mir-103a Carcinoma, Hepatocellular RESULTS: miRNA expression profiling revealed 5 miRNAs (miR-124, miR-141, miR-205, miR-208a, miR-499a) were significantly upregulated and 2 miRNAs were significantly downregulated (miR-103a, miR-15a) in HCC compared to advanced fibrosis patients. +other 35731638 hsa-mir-15a Carcinoma, Hepatocellular RESULTS: miRNA expression profiling revealed 5 miRNAs (miR-124, miR-141, miR-205, miR-208a, miR-499a) were significantly upregulated and 2 miRNAs were significantly downregulated (miR-103a, miR-15a) in HCC compared to advanced fibrosis patients. +other 35731638 hsa-mir-208a Carcinoma, Hepatocellular RESULTS: miRNA expression profiling revealed 5 miRNAs (miR-124, miR-141, miR-205, miR-208a, miR-499a) were significantly upregulated and 2 miRNAs were significantly downregulated (miR-103a, miR-15a) in HCC compared to advanced fibrosis patients. +other 35731638 hsa-mir-141 Carcinoma, Hepatocellular RESULTS: miRNA expression profiling revealed 5 miRNAs (miR-124, miR-141, miR-205, miR-208a, miR-499a) were significantly upregulated and 2 miRNAs were significantly downregulated (miR-103a, miR-15a) in HCC compared to advanced fibrosis patients. +other 35731638 hsa-mir-124 Carcinoma, Hepatocellular RESULTS: miRNA expression profiling revealed 5 miRNAs (miR-124, miR-141, miR-205, miR-208a, miR-499a) were significantly upregulated and 2 miRNAs were significantly downregulated (miR-103a, miR-15a) in HCC compared to advanced fibrosis patients. +other 35731638 hsa-mir-155 Carcinoma, Hepatocellular No significant difference was observed in miRNA expression between advanced fibrosis and early hepatic fibrosis apart from a significant downregulation of miR5p in advanced fibrosis. +other 35731638 hsa-mir-499a Carcinoma, Hepatocellular RESULTS: miRNA expression profiling revealed 5 miRNAs (miR-124, miR-141, miR-205, miR-208a, miR-499a) were significantly upregulated and 2 miRNAs were significantly downregulated (miR-103a, miR-15a) in HCC compared to advanced fibrosis patients. +other 35731638 hsa-mir-205 Carcinoma, Hepatocellular RESULTS: miRNA expression profiling revealed 5 miRNAs (miR-124, miR-141, miR-205, miR-208a, miR-499a) were significantly upregulated and 2 miRNAs were significantly downregulated (miR-103a, miR-15a) in HCC compared to advanced fibrosis patients. +other 35731336 hsa-mir-621 Esophageal Squamous Cell Carcinoma In conclusion, circ_0000705 promoted proline metabolism and malignant progression of ESCC by regulating the miR621/PYCR1 axis. +lncRNA target 35731327 hsa-mir-223 Hepatitis B, Chronic The microRNA MiR-223 is expressed in several diseases, including HBV-associated disease, while the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome plays a major role in pyroptosis. Thus, miR-223 downregulation plays an important role in HBx-induced podocyte pyroptosis by targeting the NLRP3 inflammasome, suggesting that miR-223 is a potential therapeutic target for alleviating HBV-GN inflammation. +genetics_overexpression_suppress 35731327 hsa-mir-223 Necrobiotic Disorders Moreover, transfection with HBx and NLRP3 overexpression plasmids increased the expression of pyroptosis-related proteins, especially in the presence of miR-223 inhibitors. +lncRNA target 35731049 hsa-mir-675 Wilms Tumor RESULTS: The gene expression levels of lncRNA H19 and miR-675 were markedly downregulated in nephroblastoma tissues (p<0.05), while that of TGFBI was notably upregulated (p<0.05). CONCLUSIONS: LncRNA H19 may inhibit TGFBI expression by regulating miR-675 level, so as to weaken the proliferation and enhance the apoptosis of nephroblastoma cells. +genetics_overexpression_promote 35731017 hsa-mir-2765 Lipidoses Overexpression of miR +lncRNA target 35730908 hsa-mir-1297 Squamous Cell Carcinoma of Head and Neck TFAP2A-AS1 exerts an oncogenic effect in OSCC via the TFAP2A-AS1/miR-1297/TFAP2A axis, which may provide new targets and strategies for OSCC treatments. +lncRNA target 35730670 hsa-mir-19a Fractures, Bone CONCLUSION: This study is the first to demonstrate that the miR-19a-3p/FOXF2 axis has a pivotal role in alcohol-impaired fracture healing, and may be a potential therapeutic target. +lncRNA target 35730574 hsa-mir-206 Osteosarcoma Inhibition of miR-206 in EVs partially reversed the inhibitory effect of EVs on malignant behaviors of OS cells. +transcription factor target 35730531 hsa-mir-489 Reperfusion Injury, Cerebral Ischemia Taken together, by targeting SIRT1, elevated miR +circulation_biomarker_diagnosis_up 35730503 hsa-mir-106a Hearing Loss, Sensorineural Firstly, upregulated miR-106a was observed in the peripheral blood sample of SNHL patients. +genetics_overexpression_promote 35730500 hsa-mir-4739 Esophageal Squamous Cell Carcinoma We demonstrated that miR-4739 overexpression exerted an inhibitory effect on ESCC cells by preventing the expression of homeobox C10 via the vascular endothelial growth factor A/phosphatidylinositol 3-kinase/AKT pathway, indicating the potential of this microRNA as a treatment target in ESCC. +lncRNA target 35730485 hsa-mir-145 Triple Negative Breast Neoplasms CONCLUSION: ST8SIA6-AS1 exerts an oncogenic role in TNBC by interacting with miR5p to up-regulate CDCA3 expression and inactivate the p53/p21 signaling, highlighting ST8SIA6-AS1 as a promising molecular target to combat TNBC. +other 35730470 hsa-mir-873 Colorectal Neoplasms This study demonstrated a novel TDRG1/miR5p/PRKAR2 signaling in CRC progression. +genetics_knock down_promote 35730423 hsa-mir-125b Colorectal Neoplasms Knockdown of MIR4435-2HG/Sema4D or overexpression of miR-125b-5p inhibited CRC cell proliferation and aggressiveness; overexpression of MIR4435-2HG/Sema4D or knockdown of miR-125b-5p prompted the malignant behaviors of cancer cells. +transcription factor target 35730258 hsa-mir-144 Heart Failure 3p alleviated Dox-induced cardiac dysfunction and cell apoptosis via targeting SOCS2, providing a novel evidence of miR +lncRNA target 35730141 hsa-mir-520d Aortic Aneurysm, Thoracic CONCLUSIONS: HOXA-AS2 up-regulates KIAA1522 through targeting miR-520d-3p/IGF2BP3 to drive VSMC growth in TAA. +exosome 35729564 hsa-mir-762 Burns Moreover, the enrichment of miR-762 was detected in iPSCs-KCs-Exos and was found to target promyelocytic leukemia (PML) as a means of regulating cell migration through a mechanism tie to integrin beta1 (ITGB1). +other 35729178 hsa-mir-125a Acute Kidney Injury Pre-operative miR-125a-5p was expressed at lower levels in urine from patients with AKI when adjusted for urinary creatinine. Pre-operative levels of podocalyxin EVs, urinary particle concentrations and miR-125a-5p had moderate AKI predictive value and, in a logistic model together with ICU lactate levels, offered good (AUC = 82%) AKI prediction. +genetics_overexpression_promote 35729160 hsa-mir-18b Osteosarcoma The results showed that miR-18b-5p was overexpressed in human OS tissues and cell lines. +transcription factor target 35729047 hsa-mir-221 Arthritis, Rheumatoid The expression levels of RA-related miRs and target genes were subsequently detected, and the target of miR-221 was confirmed by the dual-luciferase reporter assay. +lncRNA target 35728587 hsa-mir-95 Stomach Neoplasms LINC01088 inhibits gastric cancer cells' proliferation, invasion, and migration by regulating the miR-95/LATS2 pathway via the ceRNA mechanism. +genetics_knock down_promote 35728571 hsa-mir-1228 Uterine Cervical Neoplasms This study aimed to investigate the functional effect of UTMD-mediated miR-1228 knockdown in cervical-cancer cells. +lncRNA target 35728350 hsa-mir-564 Aortic Dissection In particular, animal experiments demonstrated that miR-564 can alleviate the progression of AD mainly through mediating phenotypic swithing and inflammation which was consistent with clinical evaluation. +other 35727952 hsa-mir-146a Myocardial Infarction Aging impairs this miR-146a-5p-regulated MMP2/16-MLCK3-p-MLC2 contractile axis, leading to compromised contractile function and increased susceptibility to heart failure. +lncRNA target 35727063 hsa-mir-451a Nerve Degeneration 3zeta transcript upon being targeted by miR-451a promotes JNK phosphorylation hence culminating into neuronal death by activation of apoptotic machinery. +transcription factor target 35727063 hsa-mir-451a West Nile Fever Inhibition of miR-451a upon neuronal infection by JEV/WNV helped reduce apoptotic machinery activation hence providing us with possible future therapeutic strategy in ameliorating flavivirus-induced neurological manifestations and overall disease burden in terms of morbidity. +transcription factor target 35727063 hsa-mir-451a Encephalitis, Japanese Inhibition of miR-451a upon neuronal infection by JEV/WNV helped reduce apoptotic machinery activation hence providing us with possible future therapeutic strategy in ameliorating flavivirus-induced neurological manifestations and overall disease burden in terms of morbidity. +transcription factor target 35727063 hsa-mir-451a Death 3zeta transcript upon being targeted by miR-451a promotes JNK phosphorylation hence culminating into neuronal death by activation of apoptotic machinery. +genetics_overexpression_promote 35726535 hsa-mir-181a Hypertrophy Cardiac hypertrophy was suppressed by overexpression of a miR-181a inhibitor and enhanced by overexpression of a miR-181a mimic. +circulation_biomarker_diagnosis_ns 35726148 hsa-mir-375 Esophageal Squamous Cell Carcinoma Particularly, plasma miR-31 and miR-375 showed high sensitivity and specificity for differentiating ESCC patients from healthy controls. +circulation_biomarker_diagnosis_ns 35726148 hsa-mir-1 Esophageal Squamous Cell Carcinoma Particularly, plasma miR-31 and miR-375 showed high sensitivity and specificity for differentiating ESCC patients from healthy controls. +circRNA target 35726081 hsa-mir-185 Parkinson Disease Hsa_circ_0004381 could contribute to MPP(+)-triggered neuron injury by targeting the miR5p/RAC1 axis, which provided a novel insight into the pathogenesis and treatment of PD. +genetics_knock down_promote 35725976 hsa-mir-448 Colorectal Neoplasms Knockdown of XIST upregulates miR-448 to impede malignant behaviors of CRC cells via inhibiting GRHL2. +other 35725663 hsa-mir-200a Anorectal Malformations Several DEMs related to development, namely miR-200a-3p, miR-200b-3p, miR-200c-3p, miR-200a-5p, and miR-429, were selected for further analysis. +other 35725663 hsa-mir-200b Anorectal Malformations Several DEMs related to development, namely miR-200a-3p, miR-200b-3p, miR-200c-3p, miR-200a-5p, and miR-429, were selected for further analysis. +other 35725663 hsa-mir-200 Anorectal Malformations Notably, compared to the control, the relative expression of miR-200 family members was highly upregulated in ARM fetal rats. CONCLUSIONS: Our findings suggest the involvement of ncRNAs, especially the miR-200 family members, in the pathogenesis of lumbosacral spinal cord dysplasia in ARM fetal rats. +other 35725663 hsa-mir-429 Anorectal Malformations Several DEMs related to development, namely miR-200a-3p, miR-200b-3p, miR-200c-3p, miR-200a-5p, and miR-429, were selected for further analysis. +other 35725663 hsa-mir-200c Anorectal Malformations Several DEMs related to development, namely miR-200a-3p, miR-200b-3p, miR-200c-3p, miR-200a-5p, and miR-429, were selected for further analysis. +other 35725615 hsa-mir-486 Carcinoma, Non-Small-Cell Lung Taken togeter, these data revealed the important role of circ-EPB41 in regulating NSCLC cell invasion and proliferation by modifying miR3p/eIF5A axis-mediated stemness. +transcription factor target 35725311 hsa-mir-200c Chronic Rhinosinusitis With Nasal Polyps GSEA demonstrated that interferon-related signaling pathways were up-regulated in non-ECRSwNP, and miRNA-200B/miRNA-200C/miRNA-429 pathways targeting ACE2 were enriched in ECRSwNP. +transcription factor target 35725311 hsa-mir-200c Nasal Polyps GSEA demonstrated that interferon-related signaling pathways were up-regulated in non-ECRSwNP, and miRNA-200B/miRNA-200C/miRNA-429 pathways targeting ACE2 were enriched in ECRSwNP. +transcription factor target 35725311 hsa-mir-200b Nasal Polyps GSEA demonstrated that interferon-related signaling pathways were up-regulated in non-ECRSwNP, and miRNA-200B/miRNA-200C/miRNA-429 pathways targeting ACE2 were enriched in ECRSwNP. +transcription factor target 35725311 hsa-mir-200b Chronic Rhinosinusitis With Nasal Polyps GSEA demonstrated that interferon-related signaling pathways were up-regulated in non-ECRSwNP, and miRNA-200B/miRNA-200C/miRNA-429 pathways targeting ACE2 were enriched in ECRSwNP. +transcription factor target 35725311 hsa-mir-429 Nasal Polyps GSEA demonstrated that interferon-related signaling pathways were up-regulated in non-ECRSwNP, and miRNA-200B/miRNA-200C/miRNA-429 pathways targeting ACE2 were enriched in ECRSwNP. +transcription factor target 35725311 hsa-mir-429 Chronic Rhinosinusitis With Nasal Polyps GSEA demonstrated that interferon-related signaling pathways were up-regulated in non-ECRSwNP, and miRNA-200B/miRNA-200C/miRNA-429 pathways targeting ACE2 were enriched in ECRSwNP. +genetics_GWAS 35724768 hsa-mir-26b Pulmonary Arterial Hypertension In addition, it was found that SNPs influenced the COX-2, miR-26b-5p, and miR-146a-5p levels in PAH. +genetics_GWAS 35724768 hsa-mir-146a Pulmonary Arterial Hypertension In addition, it was found that SNPs influenced the COX-2, miR-26b-5p, and miR-146a-5p levels in PAH. +transcription factor target 35724605 hsa-mir-203a Colitis CONCLUSION: HucMSC-Ex ameliorates colitis through the suppression of casp11/4-induced macrophage pyroptosis, and hucMSC-Ex carrying miR-203a-3p.2 inhibits casp4-induced macrophage pyroptosis in an inflammatory environment. +other 35724459 hsa-let-7c Lip Neoplasms Particularly, we identified three miRNA signatures in which miR-128a was significantly upregulated and miR-23a and let-7c were significantly downregulated in patients with lower lip cancer. Remarkably, let-7c identified to be a promising prognostic factor for lip cancer. +exosome 35724457 hsa-mir-497 Cardiomyopathies Therefore, we determine that MSCs-derived exosomes prevent sepsis-induced myocardial injury by a circRTN4/miR5p/MG53 pathway. +exosome 35724457 hsa-mir-497 Sepsis Therefore, we determine that MSCs-derived exosomes prevent sepsis-induced myocardial injury by a circRTN4/miR5p/MG53 pathway. +lncRNA target 35724456 hsa-mir-371a Liver Neoplasms The above results revealed that PTEN functioned as a key target to regulate the autophagy in the process where emodin inhibited the malignant outcome of LCCLs via miR-371a-5p, which further provided a theoretical basis for the application of traditional Chinese medicine (TCM) on clinical tumors. +circRNA target 35723810 hsa-mir-526b Carcinoma, Hepatocellular Functionally, circEIF3I regulation in HCC cell progression was associated with miR-526b-5p sponging function and HGF upregulation could attenuate tumor-inhibiting roles of miR-526b-5p. CONCLUSION: CircEIF3I was an oncogenic circRNA in HCC-, and interfering circEIF3I exhibited anti-HCC activity via circEIF3I-miR-526b-5p-HGF/c-Met pathway. +genetics_knock down_promote 35723715 hsa-mir-128 Pulpitis CONCLUSION: This study revealed that knockdown of PVT1 may suppress the damage in pulpitis cell models induced by LPS via targeting miR +other 35723551 hsa-mir-1183 Osteoarthritis RESULTS: CircCDK14 and KLF5 expression were significantly decreased, while miR-1183 was increased in OA cartilage tissues and IL-1beta-treated chondrocytes in comparison with controls. CONCLUSION: CircCDK14 reintroduction assuaged IL-1beta-caused chondrocyte damage by the miR-1183/KLF5 pathway, providing a diagnostic biomarker for OA. +genetics_overexpression_promote 35723400 hsa-mir-1290 Carcinoma, Ovarian Epithelial In the EOC group, miRNA-1290 was significantly overexpressed in serum exosomes and tissues as compared to benign ovarian neoplasm group (fold change >/= 2, p < 0.05). Serum exosomal miR-1290 could be considered as a biomarker for differential diagnosis of EOC from benign ovarian neoplasm and SOCS4 might be potential target gene of miR-1290 in EOC. +other 35723379 hsa-mir-93 Squamous Cell Carcinoma of Head and Neck 5p and H19 in OSCC. +other 35723379 hsa-mir-205 Squamous Cell Carcinoma of Head and Neck 5p and H19 in OSCC. +other 35723379 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck 5p and H19 in OSCC. +other 35723379 hsa-mir-200c Squamous Cell Carcinoma of Head and Neck 5p and H19 in OSCC. +target gene 35723348 hsa-mir-22 Carcinoma, Hepatocellular MicroRNA-22-3p and MicroRNA-149-5p Inhibit Human Hepatocellular Carcinoma Cell Growth and Metastasis Properties by Regulating Methylenetetrahydrofolate Reductase. +target gene 35723348 hsa-mir-149 Carcinoma, Hepatocellular MicroRNA-22-3p and MicroRNA-149-5p Inhibit Human Hepatocellular Carcinoma Cell Growth and Metastasis Properties by Regulating Methylenetetrahydrofolate Reductase. +other 35723300 hsa-mir-1270 Osteoporosis-pseudoglioma syndrome A previous study showed that miR-1270 was upregulated in monocytes derived from postmenopausal women with OP. +exosome 35723199 hsa-mir-222 Carcinoma, Small Cell 3p/PDLIM2/PFKL axis in LSCC tumorigenesis, and in concert with the importance of TAM exosomes and glycolysis, could be potentially translated to LSCC clinics. +genetics_knock down_promote 35723188 hsa-mir-635 Carcinoma, Non-Small-Cell Lung Additionally, miR-635 re-expression suppressed NSCLC cell malignant phenotypes mentioned above and immune escape, which were attenuated by PDL1 overexpression. In all, circ_0092012 knockdown suppressed NSCLC cell oncogenic phenotypes and immune escape by miR-635/PDL1 axis. +lncRNA target 35723058 hsa-mir-145 Glomerulonephritis, Membranous 5p inhibitor and LY294002 encouraged proliferation and inflammation through PI3K/AKT pathway in HMCs. +genetics_overexpression_promote 35723009 hsa-mir-221 Carcinoma, Hepatocellular 3p was overexpressed. +genetics_knock down_suppress 35722996 hsa-mir-664b Colorectal Neoplasms CAFs-sEV circN4BP2L2 knockdown restrained CRC cell proliferation and migration by regulating miR-664b-3p/HMGB3 pathway. +lncRNA target 35722872 hsa-mir-22 Heart Defects, Congenital CONCLUSIONS: Our findings reveal a critical signaling pathway in which epicardial HDAC3 promotes compact myocardial growth by stimulating FGF9 and IGF2 through repressing miR-322 or miR-503, providing novel insights in elucidating the etiology of congenital heart defects and conceptual strategies to promote myocardial regeneration. +lncRNA target 35722872 hsa-mir-503 Heart Defects, Congenital CONCLUSIONS: Our findings reveal a critical signaling pathway in which epicardial HDAC3 promotes compact myocardial growth by stimulating FGF9 and IGF2 through repressing miR-322 or miR-503, providing novel insights in elucidating the etiology of congenital heart defects and conceptual strategies to promote myocardial regeneration. +circRNA target 35722711 hsa-mir-370 Acute Kidney Injury Circ_UBE2D2 mitigates the progression of SAKI in rats by targeting miR3p/NR4A3 axis. +lncRNA target 35722429 hsa-mir-505 Ovarian Neoplasms Our research investigated the regulatory role of lncRNA KTN1 antisense RNA1 (KTN1-AS1) in the progression of OC through the miR +transcription factor target 35722425 hsa-mir-145 Cerebral Hemorrhage 5p protects against brain injury following HICH by targeting MMP2, suggesting a possible therapeutic mechanism for HICH. +lncRNA target 35722406 hsa-mir-81 Dementia, Vascular In this study, we investigated the effect of EA at the Baihui (GV 20) and Shenting (GV 24) acupoints on spatial learning and memory ability, and the expression level of microRNA-81 (miR-81), interleukin-16 (IL-16), and postsynaptic density protein-95 (PSD-95) in the frontal cortex of VaD rats. CONCLUSIONS: In VaD rats, EA may improve spatial learning and memory through miR-81/IL-16/PSD-95 pathway. +virus_miRNA 35722385 hbv-mir-3 Hepatitis B, Chronic HBV-miR-3 was positively correlated with HBV DNA, pgRNA, and particularly HBsAg in TN CHB patients. +circRNA target 35722376 hsa-mir-548m Hyperglycemia CONCLUSIONS: In hyperglycemia, the TTR-induced increase in circ_0007411 could repress retinal neovascularization via the miR-548m/PTPN12/SKP1/EGFR pathway. +other 35722357 hsa-mir-203b Stomach Neoplasms Long non-coding RNA (FALEC) promotes malignant behaviors of gastric cancer cells by regulating miR-203b/PIM3 axis. +lncRNA target 35722355 hsa-mir-199 Osteoarthritis Our findings may lead to the development of miR-199a-5p-based targeted therapy for OA. +lncRNA target 35722355 hsa-mir-199a Osteoarthritis Our findings may lead to the development of miR-199a-5p-based targeted therapy for OA. +other 35722091 hsa-mir-181b Aortic Valve Disease The LINC00702-miR-181b-5p-SPP1 axis might participate in the development of CAVD. +lncRNA target 35721888 hsa-mir-3121 Colorectal Neoplasms CONCLUSION: TNFRSF10A-AS1 exerts a tumor-promoting function through the miR3p/HuR axis in CRC, indicating that it may be a novel target for CRC therapy. +other 35721535 hsa-mir-142 Diabetic Nephropathies Conclusion: Ferroptosis existed in glomerular intrinsic cells of ADN group and its potential key candidate gene was ALOX15 which may be regulated by miR-142 and miRNA-650, TFs (CREBBP, EP300, HDAC1, MTA1, SPI1, STAT6) and E3 ligases related to ubiquitination (PML, ZMIZ1, MARCHF1, MARCHF3, MARCHF8, MARCHF11). +other 35721225 hsa-mir-98 COVID-19 negative controls. +other 35721225 hsa-mir-423 COVID-19 negative controls. +other 35721225 hsa-mir-1246 COVID-19 negative controls. +other 35721225 hsa-mir-32 COVID-19 negative controls. +lncRNA target 35721175 hsa-mir-19b Liver Cirrhosis BMSC and FA treatment attenuated HSC activation and liver fibrosis by inhibiting cytoskeletal rearrangement and delivering miR-19b-3p to activated HSCs, inactivating RhoA/ROCK signalling. +lncRNA target 35720932 hsa-mir-130a Diabetes Mellitus, Type 2 XIST has the capacity to promote iron overload and iron overload-related T2D initiation and development through inhibition of ALK2 expression by sponging miR-130a-3p, and that targeting this axis may be an effective strategy for treating patients with T2D. +genetics_knock down_suppress 35720634 hsa-mir-488 Cicatrix In conclusion, the knockdown of lncRNA-NEAT1 expression can inhibit hypoxia-induced scar fibroblasts proliferation through regulation of the miR3p/COL3A1 axis, which will provide a novel therapeutic target for the treatment of hypertrophic scars. +genetics_knock down_promote 35720620 hsa-mir-382 Adenocarcinoma of Lung 3p inhibition promoted proliferation and inhibited apoptosis in LA cell lines, which was restored by SAE1 knockdown. +genetics_overexpression_suppress 35720506 hsa-mir-99a Uterine Cervical Neoplasms The overexpression of miR-99a-5p induced apoptosis and inhibited glycolysis in CC cells by targeting RRAGD. +other 35720471 hsa-mir-148a Colonic Neoplasms HLA-G is one of the prognostic factors in colon cancer, and decreased miR-148a expression in colon cancer tissues may be associated with HLA-G-mediated carcinogenesis. +other 35720471 hsa-mir-148 Colonic Neoplasms HLA-G is one of the prognostic factors in colon cancer, and decreased miR-148a expression in colon cancer tissues may be associated with HLA-G-mediated carcinogenesis. +other 35720314 hsa-mir-363 pancreatic adenocarcinoma Subsequently, hsa-miR3p was recognized as a critical microRNA regulating SQLE expression and thereby influencing PAAD patient outcome. +genetics_overexpression_promote 35720183 hsa-mir-29a Reperfusion Injury, Steatotic Liver Ischemia Overexpression of miR-29a-3p downregulated the expression of Ireb2 and inhibited ferroptosis. HO-1/BMMSCs could suppress ferroptosis by targeting Ireb2 via the exosomal transfer of miR-29a-3p. +other 35720085 hsa-mir-940 Intracranial Hemorrhages From the constructed miRNA-TF-mRNA regulatory network, we identified three axes, hsa-miR-940/RUNX1/TIMP1, hsa-miR-571/SP3/TIMP1, and hsa-miR-571/SP3/PLAUR, which may be involved in the development of ICH. +other 35719399 hsa-mir-125a Zika Virus Infection 3p were related to signaling pathways modulated during infection and immune response. +other 35719399 hsa-mir-146 Zika Virus Infection 3p were related to signaling pathways modulated during infection and immune response. +other 35719399 hsa-mir-142 Zika Virus Infection 3p were related to signaling pathways modulated during infection and immune response. +other 35719385 hsa-mir-140 Respiratory Distress Syndrome In conclusion, we demonstrated a new potential regulatory mechanism underlying ARDS (the TUG1/miR5p/NFE2L2 ceRNA regulatory pathway), which may help in further exploring the pathogenesis of ARDS. +other 35719192 hsa-mir-149 uterine corpus endometrial carcinoma miR-149-3p Is a Potential Prognosis Biomarker and Correlated with Immune Infiltrates in Uterine Corpus Endometrial Carcinoma. +other 35719137 hsa-mir-206 Neuralgia CONCLUSIONS: EA can relieve neuropathic pain by regulating the miR3p/BDNF pathway, thus exerting anti-inflammatory and antiapoptotic effect. +lncRNA target 35718954 hsa-mir-214 Periodontitis Several miRNAs such as let-7 family, miR-125, miR-378, miR-543, miR-302, miR-214, miR-200, miR-146, miR-142, miR-30 and miR-21 have been shown to be dysregulated in patients with periodontitis. +lncRNA target 35718954 hsa-mir-543 Periodontitis Several miRNAs such as let-7 family, miR-125, miR-378, miR-543, miR-302, miR-214, miR-200, miR-146, miR-142, miR-30 and miR-21 have been shown to be dysregulated in patients with periodontitis. +lncRNA target 35718954 hsa-mir-125 Periodontitis Several miRNAs such as let-7 family, miR-125, miR-378, miR-543, miR-302, miR-214, miR-200, miR-146, miR-142, miR-30 and miR-21 have been shown to be dysregulated in patients with periodontitis. +lncRNA target 35718954 hsa-mir-378 Periodontitis Several miRNAs such as let-7 family, miR-125, miR-378, miR-543, miR-302, miR-214, miR-200, miR-146, miR-142, miR-30 and miR-21 have been shown to be dysregulated in patients with periodontitis. +lncRNA target 35718954 hsa-mir-142 Periodontitis Several miRNAs such as let-7 family, miR-125, miR-378, miR-543, miR-302, miR-214, miR-200, miR-146, miR-142, miR-30 and miR-21 have been shown to be dysregulated in patients with periodontitis. +lncRNA target 35718954 hsa-let-7 Periodontitis Several miRNAs such as let-7 family, miR-125, miR-378, miR-543, miR-302, miR-214, miR-200, miR-146, miR-142, miR-30 and miR-21 have been shown to be dysregulated in patients with periodontitis. +lncRNA target 35718922 hsa-mir-193b Pancreatic Carcinoma CONCLUSIONS: Our findings suggest that miR-193b expression suppresses PDAC cell proliferation, migration, invasion, and EMT through inhibition of eEF2K/MAPK-ERK oncogenic axis and that miR-193b-based RNA therapy might be an effective therapeutic strategy to control the growth of PDAC. +other 35718188 hsa-mir-125b Diabetic Retinopathy To summarize, our study revealed that crocetin has a protective effect on Hg-induced DR by regulating the lncRNA NEAT1/miR-125b-5p/SOX7 molecular axis. +genetics_overexpression_promote 35718122 hsa-mir-150 Nasopharyngeal Neoplasms The function of overexpression of miR +genetics_overexpression_promote 35717938 hsa-mir-107 Cardiomyopathies miR-107 overexpression remarkably improved cardiac function and histological changes, decreased inflammatory factors, and alleviated the sepsis-induced myocardial injury in rats. +genetics_overexpression_promote 35717938 hsa-mir-107 Sepsis miR-107 overexpression remarkably improved cardiac function and histological changes, decreased inflammatory factors, and alleviated the sepsis-induced myocardial injury in rats. +genetics_knock down_promote 35717759 hsa-mir-488 Endometriosis Circ_0004712 knockdown suppressed the proliferation and metastasis of ectopic endometrial epithelial cells via miR3p/ROCK1 axis in vitro, suggesting a new insight into the pathogenesis of endometriosis. +circulation_biomarker_diagnosis_ns 35717586 hsa-mir-122 Alcohol Withdrawal Syndrome Moreover, during AWS miR-122 but miR-30a-5p negatively correlated with serum BDNF concentrations. Thus, serum BDNF concentration and relative content of miR-122 associate with some aspects of AWS clinics and may dynamically reflect AWS severity. +target gene 35717572 hsa-mir-346 Carcinoma, Non-Small-Cell Lung Hsa_circ_0006427 Suppresses Multiplication, Migration and Invasion of Non-Small Cell Lung Cancer Cells through miR-346/VGLL4 Pathway. +genetics_knock down_promote 35717565 hsa-mir-138 Squamous Cell Carcinoma of Head and Neck 5p, and EZH2 knockdown could counteract the promotional impact of miR +transcription factor target 35717485 hsa-mir-34c Hypertension, Pulmonary Provides preliminary data to conduct studies targeting miR34c expression in vivo in animal models of pulmonary hypertension to identify the mechanistic role of miR34c in angiogenesis in the lung vasculature. +transcription factor target 35717476 hsa-mir-143 Lung Neoplasms CONCLUSION: The findings showed that miR-143 could reduce cell proliferation, invasion, and migration by reducing CXCR4, Vimentin, MMP-1, Snail-1, C-myc expression level, and increasing E-cadherin expression levels in lung cancer cells and might be a potential target in NSCLC's targeted therapy. +genetics_GWAS 35717150 hsa-mir-208b Cardiomyopathy, Hypertrophic, Familial These findings suggest that FHCM patients with MYBPC3 gene mutations have a specific miRNA expression profile, and that miR-208b-3p is significantly upregulated in cardiac hypertrophy. Our results also indicate that miRNA-208b-3p activates the Wnt signaling pathway through its target gene to promote cardiac hypertrophy. +transcription factor target 35717088 hsa-mir-466h Alzheimer Disease Two miRNA-target gene pairs (miR-125b-Pcdhgb8 pair and miR-466h-3p-IL-17Ralpha/TGF-betaR2/Abeta-42/AChE pairs) were demonstrated that they were more related to PM(2.5)-induced brain injury. +transcription factor target 35717088 hsa-mir-125b Alzheimer Disease Two miRNA-target gene pairs (miR-125b-Pcdhgb8 pair and miR-466h-3p-IL-17Ralpha/TGF-betaR2/Abeta-42/AChE pairs) were demonstrated that they were more related to PM(2.5)-induced brain injury. +other 35716750 hsa-mir-20a Neurodevelopmental Disorders The placenta sEVs derived miRNAs, especially miR-320a-3p, might contribute to an increased risk of neurodevelopmental delays. +other 35716541 hsa-mir-200a Neurotic Disorders RESULTS: XYS reduced the anxiety and depression-like behaviors associated with chronic stress and reduced the expression of miR-200a/b-3p and neuronal apoptosis in the prefrontal cortex (PFC). +other 35716513 hsa-mir-367 Schizophrenia SMAD7-EGR1 may be promising biomarkers for SCZ. +circulation_biomarker_diagnosis_down 35716001 hsa-mir-195 Pneumonia, Mycoplasma 5p was decreased in PE serum samples and cell lines, serving as a potential biomarker in protecting PE exacerbation by targeting FGF2. +lncRNA target 35715921 hsa-mir-233 Uterine Cervical Neoplasms This study suggests that XIAP MMSNs with miR-233 material suppress cervical cancer cell progression and tumor growth when augmenting radiosensitization of cancer cells, providing evidence for targeted therapy for the disease. +circulation_biomarker_diagnosis_up 35715903 hsa-mir-153 Lung Neoplasms The study's purpose was to predict micro-nodular lung cancer (mnLC), such as adenocarcinoma in situ (AIS), micro-invasive adenocarcinoma (MIA), and invasive adenocarcinoma stage 1 (IA(1)) based on serum extracellular nano-vesicles (sEVs) miR +transcription factor target 35715868 hsa-mir-181a Cardiotoxicity Finally, upregulation or downregulation of miR-181a-5p levels in MSC-EVs enhanced or weakened therapeutic effects on Dox-induced cardiotoxicity through modulating ER stress-induced apoptosis. +other 35715818 hsa-mir-888 Langer-Giedion Syndrome Specifically, incompletely resected supratentorial pLGGs with disease progression showed significantly higher miR-1248 combined with lower miR-376a-3p and miR5p levels than tumours without progression. +other 35715818 hsa-mir-1248 Langer-Giedion Syndrome Specifically, incompletely resected supratentorial pLGGs with disease progression showed significantly higher miR-1248 combined with lower miR-376a-3p and miR5p levels than tumours without progression. +other 35715818 hsa-mir-888 Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy Specifically, incompletely resected supratentorial pLGGs with disease progression showed significantly higher miR-1248 combined with lower miR-376a-3p and miR5p levels than tumours without progression. +other 35715818 hsa-mir-376a Langer-Giedion Syndrome Specifically, incompletely resected supratentorial pLGGs with disease progression showed significantly higher miR-1248 combined with lower miR-376a-3p and miR5p levels than tumours without progression. +other 35715818 hsa-mir-376a Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy Specifically, incompletely resected supratentorial pLGGs with disease progression showed significantly higher miR-1248 combined with lower miR-376a-3p and miR5p levels than tumours without progression. +other 35715818 hsa-mir-1248 Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy Specifically, incompletely resected supratentorial pLGGs with disease progression showed significantly higher miR-1248 combined with lower miR-376a-3p and miR5p levels than tumours without progression. +other 35715818 hsa-mir-1248 high grade glioma We also highlighted a critical oncogenic role for miR-1248 in gliomas tumours. +transcription factor target 35715772 hsa-mir-498 Breast Neoplasms The expression levels of three multi-target miRNAs, including miR5p, miR-146a-5p, and miR-498, as well as six downstream HRR-related protein-coding genes, have been investigated in the breast tumors and paired adjacent normal tissues by Real-time PCR. +transcription factor target 35715772 hsa-mir-146a Breast Neoplasms The expression levels of three multi-target miRNAs, including miR5p, miR-146a-5p, and miR-498, as well as six downstream HRR-related protein-coding genes, have been investigated in the breast tumors and paired adjacent normal tissues by Real-time PCR. +transcription factor target 35715772 hsa-mir-182 Breast Neoplasms The expression levels of three multi-target miRNAs, including miR5p, miR-146a-5p, and miR-498, as well as six downstream HRR-related protein-coding genes, have been investigated in the breast tumors and paired adjacent normal tissues by Real-time PCR. +transcription factor target 35715580 hsa-mir-212 Glioma 5p suppressed SUMO2 expression to regulate the proliferation, migration, and apoptosis of glioma cells. +lncRNA target 35715546 hsa-mir-155 Testicular Diseases cereus) as well as the potential role of miR-155/SIRT1/FOXO1 network in DOX-induced testicular injury. Taken together, this study reveals the prophylactic role of these two regimens on male fertility by exhibiting antioxidant, anti-inflammatory, and anti-apoptotic effects against DOX-elicited testicular damage, possibly via modulating miR-155/SIRT1/FOXO1 network. +other 35715331 hsa-mir-370 Triple Negative Breast Neoplasms 5p and miR-940, resulting in increasing the expression of a cohort of oncogenes, thus accelerating TNBC progression. +transcription factor target 35715027 hsa-mir-190 Fanconi Anemia 5p can combine with the 3'UTR of CYP6K2 to suppress its expression. +other 35714798 hsa-mir-37 Multiple Sclerosis 3p, -300, -539, -668, and -323b-5p - were upregulated in MS men, but not women when compared to controls, regardless of conflicting RNA-seq data. +other 35714798 hsa-mir-370c Multiple Sclerosis 3p, -300, -539, -668, and -323b-5p - were upregulated in MS men, but not women when compared to controls, regardless of conflicting RNA-seq data. +other 35714705 hsa-mir-16 Carcinoma, Non-Small-Cell Lung 5p/LDH-A/lactate/NF-kappaB as an important link between metabolism and NSCLC cells tumorigenesis. +circulation_biomarker_diagnosis_ns 35714213 hsa-mir-451 beta-Thalassemia CONCLUSION: miRNA-451 has a protective role against CKD development, and low plasma expression levels are associated with CKD in children with beta-TM DOI: 10.52547/ijkd.6756. +transcription factor target 35713801 hsa-mir-126a Insulin Resistance We assessed the effects of expression of adipogenic (miR-200c) and metabolic (miR-126a) miRNAs in retroperitoneal white adipose tissue (rWAT) on IR development. CONCLUSIONS: MiR-200 family dysregulation has been related to IR, and miR-126a downregulation could be associated with the improvement in IR observed after a 12-week HSD feeding period. +transcription factor target 35713801 hsa-mir-200 Insulin Resistance CONCLUSIONS: MiR-200 family dysregulation has been related to IR, and miR-126a downregulation could be associated with the improvement in IR observed after a 12-week HSD feeding period. +other 35713801 hsa-mir-200c Insulin Resistance We assessed the effects of expression of adipogenic (miR-200c) and metabolic (miR-126a) miRNAs in retroperitoneal white adipose tissue (rWAT) on IR development. +circulation_biomarker_diagnosis_ns 35713553 hsa-mir-138 Colorectal Neoplasms 5p methylated DNA in plasma as a diagnostic biomarker. +genetics_overexpression_promote 35713481 hsa-mir-200c Osteosarcoma MiR-200c overexpression suppressed the role of circCSPP1 in OS cells. +transcription factor target 35713208 hsa-mir-21 Hypertension, Pulmonary The abnormal expression of RhoA, ROCK2, Rac1 and c-Jun in the lungs of MCT-PH rats was inhibited by E(2) and miR +lncRNA target 35713138 hsa-mir-633 Stomach Neoplasms CONCLUSION: The low expression level of KAI1 and high expression of miRNA-633 are significantly correlated with the poor overall survival prognosis of malignant melanoma with gastric cancer, to provide a basis for KAI1 and miRNA-633 to become novel molecular targets for malignant melanoma with gastric cancer. +lncRNA target 35713138 hsa-mir-633 Melanoma CONCLUSION: The low expression level of KAI1 and high expression of miRNA-633 are significantly correlated with the poor overall survival prognosis of malignant melanoma with gastric cancer, to provide a basis for KAI1 and miRNA-633 to become novel molecular targets for malignant melanoma with gastric cancer. +circulation_biomarker_diagnosis_up 35712950 hsa-mir-1 Irritable Bowel Syndrome RESULTS: After modeling, the body mass and the minimum volume threshold of AWR in the model group were lower than those in the normal group (P<0.01); the rates of loose stool in the model group were higher than those in the normal group (P<0.01); after intervention, in the model group, the inflammatory infiltration of colon tissues was obvious, and the serum levels of TNF-alpha, IL-1 beta, IL-8 were higher than those in the normal group (P<0.05); the expression of miR-155, miR-125b, miR-29b, miR-31, miR-18a and NF-kappaB p65 mRNA in colon tissues was higher than that in the normal group (P<0.05); the protein expression of NF-kappaB p65, TNF-alpha, IL-1beta, IL-8 was also higher than that in the normal group (P<0.01). +circulation_biomarker_diagnosis_up 35712950 hsa-mir-29b Irritable Bowel Syndrome RESULTS: After modeling, the body mass and the minimum volume threshold of AWR in the model group were lower than those in the normal group (P<0.01); the rates of loose stool in the model group were higher than those in the normal group (P<0.01); after intervention, in the model group, the inflammatory infiltration of colon tissues was obvious, and the serum levels of TNF-alpha, IL-1 beta, IL-8 were higher than those in the normal group (P<0.05); the expression of miR-155, miR-125b, miR-29b, miR-31, miR-18a and NF-kappaB p65 mRNA in colon tissues was higher than that in the normal group (P<0.05); the protein expression of NF-kappaB p65, TNF-alpha, IL-1beta, IL-8 was also higher than that in the normal group (P<0.01). +circulation_biomarker_diagnosis_up 35712950 hsa-mir-18a Irritable Bowel Syndrome RESULTS: After modeling, the body mass and the minimum volume threshold of AWR in the model group were lower than those in the normal group (P<0.01); the rates of loose stool in the model group were higher than those in the normal group (P<0.01); after intervention, in the model group, the inflammatory infiltration of colon tissues was obvious, and the serum levels of TNF-alpha, IL-1 beta, IL-8 were higher than those in the normal group (P<0.05); the expression of miR-155, miR-125b, miR-29b, miR-31, miR-18a and NF-kappaB p65 mRNA in colon tissues was higher than that in the normal group (P<0.05); the protein expression of NF-kappaB p65, TNF-alpha, IL-1beta, IL-8 was also higher than that in the normal group (P<0.01). +circulation_biomarker_diagnosis_up 35712950 hsa-mir-125b Irritable Bowel Syndrome RESULTS: After modeling, the body mass and the minimum volume threshold of AWR in the model group were lower than those in the normal group (P<0.01); the rates of loose stool in the model group were higher than those in the normal group (P<0.01); after intervention, in the model group, the inflammatory infiltration of colon tissues was obvious, and the serum levels of TNF-alpha, IL-1 beta, IL-8 were higher than those in the normal group (P<0.05); the expression of miR-155, miR-125b, miR-29b, miR-31, miR-18a and NF-kappaB p65 mRNA in colon tissues was higher than that in the normal group (P<0.05); the protein expression of NF-kappaB p65, TNF-alpha, IL-1beta, IL-8 was also higher than that in the normal group (P<0.01). +circulation_biomarker_diagnosis_up 35712950 hsa-mir-155 Irritable Bowel Syndrome RESULTS: After modeling, the body mass and the minimum volume threshold of AWR in the model group were lower than those in the normal group (P<0.01); the rates of loose stool in the model group were higher than those in the normal group (P<0.01); after intervention, in the model group, the inflammatory infiltration of colon tissues was obvious, and the serum levels of TNF-alpha, IL-1 beta, IL-8 were higher than those in the normal group (P<0.05); the expression of miR-155, miR-125b, miR-29b, miR-31, miR-18a and NF-kappaB p65 mRNA in colon tissues was higher than that in the normal group (P<0.05); the protein expression of NF-kappaB p65, TNF-alpha, IL-1beta, IL-8 was also higher than that in the normal group (P<0.01). +transcription factor target 35712865 hsa-mir-372 Diabetes, Gestational CONCLUSION: Our results further suggested that the downregulations of miR-22 and miR-372 may contribute to GDM through regulating the PI3K/GLUT4 pathway. +transcription factor target 35712865 hsa-mir-22 Diabetes, Gestational CONCLUSION: Our results further suggested that the downregulations of miR-22 and miR-372 may contribute to GDM through regulating the PI3K/GLUT4 pathway. +lncRNA target 35712514 hsa-mir-140 Endometrial Neoplasms This study established that dysregulation of the TMPO-AS1-miR-140/miR-143 axis contributes to glycolysis and drug resistance in EC cells by up-regulating GLUT1 expression. +lncRNA target 35712514 hsa-mir-143 Endometrial Neoplasms This study established that dysregulation of the TMPO-AS1-miR-140/miR-143 axis contributes to glycolysis and drug resistance in EC cells by up-regulating GLUT1 expression. +other 35712508 hsa-mir-221 Carcinoma, Hepatocellular Mechanistically, ASAP1-IT1 might exert its role in HCC progression, at least in part, by directly interacting with miR3p. +genetics_knock down_promote 35712504 hsa-mir-576 Stomach Neoplasms CONCLUSION: These findings demonstrated that circDNMT1 knockdown inhibited GC proliferation, migration, invasion and glycolysis through sponging miR +lncRNA target 35712476 hsa-mir-148a Pancreatic Carcinoma CONCLUSIONS: Our study suggests that hsa_circ_0046523/miR-148a-3p/PD-L1 regulatory axis mediates PC immunosuppressive microenvironment and these molecules are expected to be new targets for remodeling tumor immune microenvironment of PC. +other 35712349 hsa-mir-205 lung squamous cell carcinoma The miRNA-mRNA network of miR5p (up) and PTPRM (down) was validated in 30 pairs of LUSC tissues. +other 35712307 hsa-mir-548e Post-Concussion Syndrome 5p, hsa-miR-199a-3p+hsa-miR-199b-3p). +other 35712307 hsa-mir-548y Post-Concussion Syndrome 5p, hsa-miR-199a-3p+hsa-miR-199b-3p). +other 35712307 hsa-mir-199a Post-Concussion Syndrome 5p, hsa-miR-199a-3p+hsa-miR-199b-3p). +other 35712307 hsa-mir-626 Post-Concussion Syndrome 5p, hsa-miR-199a-3p+hsa-miR-199b-3p). +other 35712307 hsa-mir-200a Post-Concussion Syndrome 5p, hsa-miR-199a-3p+hsa-miR-199b-3p). +other 35712307 hsa-mir-183 Post-Concussion Syndrome 5p, hsa-miR-199a-3p+hsa-miR-199b-3p). +other 35712307 hsa-mir-378h Post-Concussion Syndrome 5p, hsa-miR-199a-3p+hsa-miR-199b-3p). +other 35712307 hsa-mir-203a Post-Concussion Syndrome Among these 13 miRNAs, one (i.e., hsa-miR-203a-5p) was also identified in a prior study, with significantly different expression levels between children with and without PPCS. +other 35712307 hsa-mir-585 Post-Concussion Syndrome 5p, hsa-miR-199a-3p+hsa-miR-199b-3p). +other 35712307 hsa-mir-888 Post-Concussion Syndrome 5p, hsa-miR-199a-3p+hsa-miR-199b-3p). +other 35712307 hsa-mir-95 Post-Concussion Syndrome 5p, hsa-miR-199a-3p+hsa-miR-199b-3p). +other 35712307 hsa-mir-1323 Post-Concussion Syndrome 5p, hsa-miR-199a-3p+hsa-miR-199b-3p). +other 35712307 hsa-mir-199b Post-Concussion Syndrome 5p, hsa-miR-199a-3p+hsa-miR-199b-3p). +circulation_biomarker_diagnosis_ns 35712251 hsa-mir-193b Diabetes Mellitus, Type 2 RESULTS: miR-193b-3p was differentially expressed in type 2 diabetes cases compared to healthy controls (fold change = 2.01, P = 0.006). CONCLUSION: Plasma miR-193b-3p levels increased in type 2 diabetes cases, and TPI1 levels decreased in both plasma and HepG2 cells with increased miR-193b-3p levels, while extracellular lactate levels did not significantly changed. +circulation_biomarker_diagnosis_ns 35712057 hsa-mir-21 Breast Neoplasms Prognosticating 2-Year Survival Rate of Breast Cancer Patients Through Plasma BACKGROUND: miRNA-21, one of breast cancer (BC) predictive markers, is now gaining cardinal attention from researchers worldwide to evaluate BC patients' survival rate. We aim to determine the relationship between miRNA-21 and associating factors such as BC staging, other tumor markers, and hormonal status to predict the 2-year survival rate of BC patients. +other 35711934 hsa-mir-185 Intervertebral Disc Degeneration Also, qRT-PCR results showed that ARHGAP27, C15orf39, DEPDC1, DHRSX, MGAM, SLC11A1, SMC4, and LINC00887 were significantly downregulated in degenerative NPCs; H19, LINC00685, mir5p, and mir-4306 were upregulated in degenerative NPCs; and the expression level of mir-663a did not change significantly in normal and degenerative NPCs. +other 35711934 hsa-mir-4306 Intervertebral Disc Degeneration Also, qRT-PCR results showed that ARHGAP27, C15orf39, DEPDC1, DHRSX, MGAM, SLC11A1, SMC4, and LINC00887 were significantly downregulated in degenerative NPCs; H19, LINC00685, mir5p, and mir-4306 were upregulated in degenerative NPCs; and the expression level of mir-663a did not change significantly in normal and degenerative NPCs. +other 35711934 hsa-mir-663a Intervertebral Disc Degeneration Also, qRT-PCR results showed that ARHGAP27, C15orf39, DEPDC1, DHRSX, MGAM, SLC11A1, SMC4, and LINC00887 were significantly downregulated in degenerative NPCs; H19, LINC00685, mir5p, and mir-4306 were upregulated in degenerative NPCs; and the expression level of mir-663a did not change significantly in normal and degenerative NPCs. +lncRNA target 35711847 hsa-mir-489 Carcinoma, Non-Small-Cell Lung Conclusion: Taken together, our findings revealed that IL-1beta-induced elevation of lncRNA CHRF aggravated NSCLC through modulation of miR-489/Myd88 axis, which provides a novel direction for NSCLC therapy development. +target gene 35711826 hsa-mir-29b-1 Stomach Neoplasms The Curcumin Analog Da0324 Inhibits the Proliferation of Gastric Cancer Cells via HOTAIRM1/miR-29b-1-5p/PHLPP1 Axis. +transcription factor target 35711801 hsa-mir-216 Fatty Liver Furthermore, the dual luciferase gene reporter assay and RT-qPCR analysis demonstrated that 3-hydroxyacyl-CoA dehydratase 2, F-box protein 8, and transmembrane 9 superfamily member 3 (TM9SF3) were directly targeted by miR-216a/b and miR5p, respectively, and suppressed in the fatty livers of laying hens. +transcription factor target 35711801 hsa-mir-217 Fatty Liver Furthermore, the dual luciferase gene reporter assay and RT-qPCR analysis demonstrated that 3-hydroxyacyl-CoA dehydratase 2, F-box protein 8, and transmembrane 9 superfamily member 3 (TM9SF3) were directly targeted by miR-216a/b and miR5p, respectively, and suppressed in the fatty livers of laying hens. +transcription factor target 35711801 hsa-mir-216a Fatty Liver Furthermore, the dual luciferase gene reporter assay and RT-qPCR analysis demonstrated that 3-hydroxyacyl-CoA dehydratase 2, F-box protein 8, and transmembrane 9 superfamily member 3 (TM9SF3) were directly targeted by miR-216a/b and miR5p, respectively, and suppressed in the fatty livers of laying hens. +transcription factor target 35711428 hsa-mir-182 Asthma In summary, targeting miRNA +exosome 35711020 hsa-mir-626 Mouth Neoplasms CONCLUSIONS: Our data demonstrate that exosomal miR-626 can facilitate the development of oral cancer by inhibiting the expression of its target NFIB. +circulation_biomarker_diagnosis_down 35710817 hsa-mir-628 Prostatic Neoplasms 5p (miR-628) as a potential biomarker in serum samples from men with prostate cancer (PCa) (Srivastava et al. +circulation_biomarker_prognosis_up 35710767 hsa-mir-141 Gallbladder Neoplasms Elevated expression of circulating miR-141 in peripheral blood might be a potential novel biomarker for diagnosis and prognosis of GBC patients. +genetics_overexpression_promote 35710754 hsa-mir-107 Colorectal Neoplasms Overexpression of RUNX3, circMETTL3, or PER3 suppressed while miR-107 mimics promoted, CRC cell proliferation and invasion, as well as tumor growth and metastasis in vivo. +genetics_overexpression_promote 35710537 hsa-mir-140 Postoperative Cognitive Complications 3p or HTR2A overexpression or activation of ERK/Nrf2 pathway elevated neuron viability and diminished their apoptosis and pyroptosis while alleviating Sevo-induced POCD in rats. +genetics_overexpression_promote 35710537 hsa-mir-140 Cognition Disorders 3p or HTR2A overexpression or activation of ERK/Nrf2 pathway elevated neuron viability and diminished their apoptosis and pyroptosis while alleviating Sevo-induced POCD in rats. +transcription factor target 35710416 hsa-mir-188 Azoospermia, Nonobstructive 3p may regulate its target gene ATG7 to participate in autophagy anDual luciferase experiment d affect the development of NOA. +lncRNA target 35710311 hsa-mir-28 Ovarian Neoplasms CircAHNAK deficiency resulted in the amassing of miR-28, which was elevated in ovarian cancer and promoted cancer cell malignancy. In conclusion, circAHNAK targets miR-28 to upregulate EIF2B5 expression, thus inhibits progression of ovarian cancer by suppressing JAK2/STAT3 signaling pathway. +lncRNA target 35710093 hsa-mir-16 Carcinoma, Hepatocellular Thus, we revealed that circPTTG1IP is a novel tumor suppresser circRNA in HCC and that a low circPTTG1IP level promotes HCC development via the miR5p/RNF125/JAK1 axis. +other 35710089 hsa-mir-677 Lung Diseases Guinea pigs showed no obvious pathological changes and less severe lung lesions in bta-miR-677 agomir treated group at 7 dpi. +genetics_overexpression_promote 35710089 hsa-mir-677 Cataract, posterior polar, 3 Bta-miR-677 overexpression promoted type I interferon (IFN-I) and IFN-stimulated genes (ISGs) production, thereby inhibiting CPIV3 replication, while bta-miR-677 inhibitor suppressed the antiviral innate immune response to promoted viral replication in MDBK cells. +circulation_biomarker_diagnosis_ns 35709892 hsa-mir-132 Alzheimer Disease Finally, using peripheral blood samples of human study participants, we found that the miR +transcription factor target 35708762 hsa-mir-125b Diabetic Angiopathies Through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway, high glucose induced miR-125b-5p, which in turn targeted SIRT7 in myeloid cells and was directly associated with coronary calcification. +genetics_overexpression_promote 35708677 hsa-mir-194 Stomach Neoplasms 5p overexpression attenuated the malignant phenotypes of GC cells. +exosome 35708510 hsa-mir-31 Uterine Cervical Neoplasms The aim of this study is to investigate if extracellular vesicles (EVs) from bone marrow mesenchymal stem cells (BMSCs) deliver microRNA (miR) +other 35708203 hsa-mir-126 Dengue CmiR3p expression during febrile and convalescent phases in dengue-infected patients was significantly lower than AFI (p < 0.05). +genetics_knock down_suppress 35708150 hsa-mir-29a Inflammation Collectively, these data demonstrated that NEAT1 knockdown inhibited hypoxia-induced cell apoptosis, inflammation, and fibrosis by targeting the miR-29a/NFATc3 axis in PF, suggesting that NEAT1 might be a potential therapeutic target for relieving PF progression. +genetics_knock down_suppress 35708150 hsa-mir-29a Diabetic Nephropathies Collectively, these data demonstrated that NEAT1 knockdown inhibited hypoxia-induced cell apoptosis, inflammation, and fibrosis by targeting the miR-29a/NFATc3 axis in PF, suggesting that NEAT1 might be a potential therapeutic target for relieving PF progression. +genetics_overexpression_promote 35707935 hsa-mir-1288 Squamous Cell Carcinoma of Head and Neck 3p, whose upregulation promoted OSCC progression and eliminated the effects of overexpression of hsa_circ_0096042 on OSCC cells. +genetics_GWAS 35707883 hsa-mir-21 Lupus Erythematosus, Systemic This study evaluated the association between the genetic variants of microRNA-21 (miR-21) and microRNA-155 (miR-155) and SLE. +genetics_GWAS 35707883 hsa-mir-155 Lupus Erythematosus, Systemic This study evaluated the association between the genetic variants of microRNA-21 (miR-21) and microRNA-155 (miR-155) and SLE. +lncRNA target 35707849 hsa-mir-23a Myasthenia Gravis CONCLUSION: Collectively, our results indicate that GAS5 can regulate the Th17/Treg balance by targeting miR-23a expression, providing a scientific basis for clinical therapeutic development for MG. +transcription factor target 35707845 hsa-mir-20a Osteoarthritis In conclusion, miR-20a-5p facilitates BMSC chondrogenic differentiation and contributes to cartilage repair in OA by suppressing Map3k2. +epigenetics 35707350 hsa-mir-23 Multiple Myeloma Hypermethylation of the Promoter Region of miR-23 Enhances the Metastasis and Proliferation of Multiple Myeloma Cells via the Aberrant Expression of uPA. +epigenetics 35706811 hsa-mir-657 Carcinoma, Hepatocellular ROC curve analysis revealed that the mean methylation level of the miR-657 promoter region could distinguish cancerous tissues from paired normal tissues of HCC patients (area under the curve: 0.847, P<0.001). +exosome 35706810 hsa-mir-142 Liver Neoplasms HBV-positive liver cancer cell exosomal miR-142-3p can promote the progression of liver cancer by inducing iron death of M1-type macrophages. +circRNA target 35706804 hsa-mir-1290 Glioblastoma Hsa-miR-1248 and hsa-miR-1290 were up regulated and related to glioblastoma poor prognosis. In this network, hsa_circ_0001073, hsa_circ_0070700, hsa_circ_0000219, hsa-miR-1248, hsa-miR-1290, and RNF11 may have the potential being emerging glioblastoma therapeutic targets. +circRNA target 35706804 hsa-mir-1248 Glioblastoma Hsa-miR-1248 and hsa-miR-1290 were up regulated and related to glioblastoma poor prognosis. In this network, hsa_circ_0001073, hsa_circ_0070700, hsa_circ_0000219, hsa-miR-1248, hsa-miR-1290, and RNF11 may have the potential being emerging glioblastoma therapeutic targets. +circulation_biomarker_diagnosis_ns 35706801 hsa-mir-148b Urinary Bladder Neoplasms 5p and miR-148b-3p) in serum were obviously dysregulated in BC patients compared to HCs. +circulation_biomarker_diagnosis_ns 35706801 hsa-mir-132 Urinary Bladder Neoplasms 5p and miR-148b-3p) in serum were obviously dysregulated in BC patients compared to HCs. +circulation_biomarker_diagnosis_ns 35706801 hsa-mir-7 Urinary Bladder Neoplasms 5p and miR-148b-3p) in serum were obviously dysregulated in BC patients compared to HCs. +target gene 35706791 hsa-mir-195 Carcinoma, Non-Small-Cell Lung LncRNA OXCT1-AS1 promotes the proliferation of non-small cell lung cancer cells by targeting the miR-195/CCNE1 axis. +other 35706417 hsa-mir-383 Venous Thrombosis Therefore, the lncRNA-MALAT1/miR5p/BCL2L11 axis may be effective for DVT treatment. +lncRNA target 35706403 hsa-mir-1225 Keloid Therefore, our results show that hsa_circ_0057452 promotes keloid progression by targeting miR +genetics_overexpression_suppress 35706019 hsa-mir-485 Mouth Neoplasms 5p inhibited OSCC sphere formation and caused sensitization of cancer cells towards cisplatin and carboplatin, which could be significantly rescued by KRT17 overexpression. +circulation_biomarker_diagnosis_up 35706002 hsa-mir-613 Carcinoma, Hepatocellular BACKGROUND: This study aimed to explore the specific pathogenesis of lncRNA MALAT1 promoting the invasion and metastasis of hepatocellular carcinoma (HCC) through peripheral blood vessels by regulating the expression of miRNA-613 molecule. +circulation_biomarker_diagnosis_up 35705894 hsa-mir-200a Hypertension High serum miR-200a-3p expression in HDCP patients was associated with increased adverse pregnancy outcomes. +lncRNA target 35705830 hsa-mir-188 Vasculitis 5p suppressed Dox-induced vascular inflammation in vitro. +circulation_biomarker_diagnosis_ns 35705319 hsa-mir-1229 Cardiomyopathies 5p inhibitor under serum-EVs treatment reduced the protective effect of serum-EVs on myocardial cell injury, decreased cell proliferation, increased the number of apoptotic cells, and increased myocardial injury indicator concentration. +genetics_knock down_promote 35705019 hsa-mir-30 Uterine Cervical Neoplasms CONCLUSIONS: BCYRN1 knockdown could disrupt the DDP-resistance of CC cells through upregulating miR +other 35704723 hsa-mir-29b COVID-19 5p, microRNA-5695, and microRNA-29b-3p were upregulated in SARS-CoV-2 cases and down-regulated in non-SARS-CoV-2 cases. +other 35704723 hsa-mir-6501 COVID-19 5p, microRNA-5695, and microRNA-29b-3p were upregulated in SARS-CoV-2 cases and down-regulated in non-SARS-CoV-2 cases. +other 35704723 hsa-mir-5695 COVID-19 5p, microRNA-5695, and microRNA-29b-3p were upregulated in SARS-CoV-2 cases and down-regulated in non-SARS-CoV-2 cases. +genetics_GWAS 35704669 hsa-mir-1 Lumbar Disc Herniation Our results shown that in the Chinese Han population, the MIR31HG polymorphism rs10965059 was involved in a risk to symptomatic LDH, which provides a scientific basis for early screening, prevention, diagnosis and treatment of local LDH high-risk populations. +other 35704638 hsa-mir-33a Esophageal Neoplasms ST6GAL1, SPAG5-AS1-miR-133a-ST6GAL1, and SNHG12-hsa-miR-33a-ST6GA interactions, associated with the N-glycan biosynthesis pathway, may have key roles in alcohol-related EC. +other 35704638 hsa-mir-1 Esophageal Neoplasms ST6GAL1, SPAG5-AS1-miR-133a-ST6GAL1, and SNHG12-hsa-miR-33a-ST6GA interactions, associated with the N-glycan biosynthesis pathway, may have key roles in alcohol-related EC. +other 35704638 hsa-mir-133a Esophageal Neoplasms ST6GAL1, SPAG5-AS1-miR-133a-ST6GAL1, and SNHG12-hsa-miR-33a-ST6GA interactions, associated with the N-glycan biosynthesis pathway, may have key roles in alcohol-related EC. +other 35704597 hsa-mir-199 Diabetes Mellitus Further studies are needed to confirm Klotho and hsa-miR5p as markers for T2DM complications. +transcription factor target 35704246 hsa-mir-375 Plaque, Atherosclerotic CONCLUSION: METTL3-mediated m(6)A modification promoted VSMC phenotype transformation and made AS plaques more vulnerable via the miR3p/PDK1 axis. +genetics_overexpression_promote 35704145 hsa-mir-25 Sepsis-Associated Encephalopathy 3p overexpression attenuated the activation of microglia in SAE by inhibiting the NLRP3/IL-1beta/IL-18 axis by directly targeting TLR4, suggesting that miR +other 35703738 hsa-mir-34a Myocardial Reperfusion Injury This study was designed to investigate whether microRNA-34a (miR-34a) influences cardiac I/R or hypoxia/reoxygenation (H/R) injury by regulating the mitochondrial apoptotic pathway from oxidative injury.In vivo, myocardial infarction size was examined by Evan blue/TTC staining. +lncRNA target 35703693 hsa-mir-589 Spinal Cord Injuries In summary, these data revealed that KCNQ1OT1 promoted inflammatory response and apoptosis of microglia by regulating the miR5p/NPTN axis after SCI, which may offer a novel promising therapeutic target for SCI. +circulation_biomarker_diagnosis_ns 35703473 hsa-mir-122 Liver Diseases Serum concentrations of microRNA (miR)-122 have been shown in humans, dogs and rodents to be a sensitive and specific biomarker for liver injury. This work highlights the potential diagnostic utility of miR-122 as a biomarker of liver damage in cats and encourages further investigation to determine the sensitivity and specificity of miR-122 as a biomarker of hepatocellular injury in this species. +circulation_biomarker_diagnosis_ns 35703473 hsa-mir-122 Chemical and Drug Induced Liver Injury Serum concentrations of microRNA (miR)-122 have been shown in humans, dogs and rodents to be a sensitive and specific biomarker for liver injury. This work highlights the potential diagnostic utility of miR-122 as a biomarker of liver damage in cats and encourages further investigation to determine the sensitivity and specificity of miR-122 as a biomarker of hepatocellular injury in this species. +lncRNA target 35703357 hsa-mir-205 Melanoma Cell Counting Kit8 and flow cytometry assays indicated the suppression of proliferation of melanoma cells following inhibition of MIR205HG expression. +genetics_overexpression_promote 35703312 hsa-mir-138 Triple Negative Breast Neoplasms Decreased proliferation rate of TNBC cells was observed after overexpression of MT1JP and miR-138. +exosome 35703190 hsa-mir-490 Esophageal Squamous Cell Carcinoma In conclusion, exosomal circFNDC3B drove ESCC progression via regulating the miR5p/TXNRD1 axis.AbbreviationsEC: esophageal cancer; ESCC: esophageal squamous cell carcinoma; circRNA: circular RNA; WB: western blot; TEM: transmission electron microscopy; NTA: nanoparticle tracking analysis; TXNRD1: thioredoxin reductase 1; IHC: immunohistochemistry; RT-qPCR: reverse transcription-polymerase quantitative chain reaction; GLUT1: glucose transport protein type 1; LDHA: lactate dehydrogenase A. +genetics_overexpression_promote 35702784 hsa-mir-1202 Lung Neoplasms CERS6-AS1 silencing or miR-1202 overexpression reversed the impacts induced by IGF2BP3 on lung cancer. +transcription factor target 35702326 hsa-mir-5682 Dmd-Associated Dilated Cardiomyopathy Additionally, visualization of the interactions between miRNAs and the hub genes revealed that hsa-miR-5682 and hsa-miR-4500 interacted with both COL3A1 and COL1A2, and thus these miRNAs might play roles in DCM. CONCLUSION: COL1A2 and COL3A1 and their targeting miRNAs, hsa-miR-5682 and hsa-miR-4500, may play critical roles in the pathogenesis of DCM, which are closely related to the IL-17 signaling pathway and acute inflammatory response. +transcription factor target 35702326 hsa-mir-4500 Dmd-Associated Dilated Cardiomyopathy Additionally, visualization of the interactions between miRNAs and the hub genes revealed that hsa-miR-5682 and hsa-miR-4500 interacted with both COL3A1 and COL1A2, and thus these miRNAs might play roles in DCM. CONCLUSION: COL1A2 and COL3A1 and their targeting miRNAs, hsa-miR-5682 and hsa-miR-4500, may play critical roles in the pathogenesis of DCM, which are closely related to the IL-17 signaling pathway and acute inflammatory response. +other 35702258 hsa-mir-105 Carcinoma, Hepatocellular CONCLUSIONS: Our findings could provide insights into the selection of novel LINC00261/MiR105-5p/SELL pathway which is associated with overall survival and may impact on efficacy of immunotherapy in HCC. +target gene 35702180 hsa-mir-144 Colorectal Neoplasms Dysregulation of MiR-144-5p/RNF187 Axis Contributes To the Progression of Colorectal Cancer. +transcription factor target 35702088 hsa-mir-135a Arthritis, Rheumatoid Moreover, STAT6 was involved in the regulation of miR-135a-5p on cell growth, apoptosis and inflammatory response of RA FLSs. CONCLUSION: miR-135a-5p/STAT6 is a potential novel therapeutic target for RA treatment. +other 35702084 hsa-mir-129 Glioma CONCLUSION: LINC00665 functions as an oncogenic lncRNA in glioma, to accelerate glioma progression by modulating miR5p and increasing HMGB1 expression. +lncRNA target 35702078 hsa-mir-486 Carcinoma, Non-Small-Cell Lung CONCLUSION: In our study, we elaborated that LncRNA PCAT7 could promote the development of NSCLC cells by accelerating cell cycle via miR +transcription factor target 35701740 hsa-mir-335 Corneal Neovascularization CONCLUSIONS: In general, our data confirmed that miR-335 facilitated the process of CRNV by targeting EGFR. +circulation_biomarker_diagnosis_up 35700796 hsa-mir-221 Osteoporosis METHODS: Serum from patients with postmenopausal osteoporosis and healthy controls was collected for determination of miR +circulation_biomarker_diagnosis_ns 35700789 hsa-mir-1225 familial temporal lobe epilepsy 3 CONCLUSIONS: Our data suggest the existence of three circulating miRNAs (miR +circulation_biomarker_diagnosis_ns 35700789 hsa-mir-629 familial temporal lobe epilepsy 3 CONCLUSIONS: Our data suggest the existence of three circulating miRNAs (miR +circulation_biomarker_diagnosis_ns 35700789 hsa-mir-1202 familial temporal lobe epilepsy 3 CONCLUSIONS: Our data suggest the existence of three circulating miRNAs (miR +other 35700742 hsa-mir-27a Prostatic Neoplasms These findings offer the possibility of employing the miR-124 and miR-27a-3p as therapeutic agents for prostate cancer treatment. +other 35700742 hsa-mir-124 Prostatic Neoplasms These findings offer the possibility of employing the miR-124 and miR-27a-3p as therapeutic agents for prostate cancer treatment. +genetics_knock down_promote 35700738 hsa-mir-690 Diabetic Nephropathies KC-specific KO of miR-690 promotes NASH pathogenesis. +genetics_knock down_promote 35700738 hsa-mir-690 non-alcoholic steatohepatitis KC-specific KO of miR-690 promotes NASH pathogenesis. +other 35700709 hsa-mir-181a Carcinoma, Non-Small-Cell Lung miR-181a-5p restrains non-small cell lung cancer cell invasion and migration by regulating the GTSE1/p53/NF-κB axis. +genetics_overexpression_suppress 35700579 hsa-mir-340 Laryngeal Neoplasms 5p overexpression reduced lncRNA NEAT1 stability via binding to lncRNA NEAT1, which declined lncRNA NEAT1 expression and reduced the binding of lncRNA NEAT1 to HSF1 to further inhibit MMP11 transcription, thus repressing LC cell proliferation and invasion. +lncRNA target 35700516 hsa-mir-485 Nasopharyngeal Carcinoma 3p/SOX9, indicating that circSOX9 can be used as a potential therapeutic target and predictive marker for nasopharyngeal carcinoma. +circulation_biomarker_prognosis_down 35700456 hsa-mir-15a Subarachnoid Hemorrhage The expression of miR-15a was significantly repressed in the peripheral blood and CSF of SAH patients carrying the AT allele when compared with that in patients carrying the AA allele. CONCLUSIONS: The findings demonstrated that the presence of the minor allele of rs17427875 in lncRNA-HOXA11-AS could increase the expression level of lncRNA-HOXA11-AS, thus elevating the expression level of STAT3 via down-regulating miR-15a, and increased STAT3 expression could aggravate inflammation to cause poor prognosis of SAH. +other 35700382 hsa-mir-375 Neoplasms, Germ Cell and Embryonal Statistically significant and high expression of microRNA375 attributable for yolk sac tumors and immature teratomas. +genetics_overexpression_promote 35699870 hsa-mir-29b Myocardial Infarction ADAMTS16 overexpression accelerated MI in rats, and ADAMTS16 upregulation reversed the protective effects of miR-29b-3p upregulation on MI rats. +other 35699802 hsa-mir-3551 Spinal Cord Injuries Our study revealed that circHecw1 regulates SCI neuronal cell inflammation imbalance by regulating the miR3p/LRRTM1 signaling. +lncRNA target 35699307 hsa-mir-21 Carcinoma, Pancreatic Ductal Here we specifically evaluate the capability of PSD to enhance RNA nanomedicine delivery, using a NP carrying an inhibitor of miR5P, a PDAC oncomiR. +transcription factor target 35699095 hsa-mir-665 Carcinoma, Hepatocellular It also inhibited miR-665 expression in HCC cells. We further observed that sevoflurane inhibited HCC metastasis via miR-665. +circulation_biomarker_diagnosis_ns 35698951 hsa-mir-20 Lung Diseases CONCLUSION: Our findings demonstrate that miR-320c inhibits SERPINA1 expression in a hepatic cell line and its levels in blood are associated with lung disease in a cohort of patients with different AAT serum levels. +circulation_biomarker_diagnosis_ns 35698951 hsa-mir-320c Lung Diseases CONCLUSION: Our findings demonstrate that miR-320c inhibits SERPINA1 expression in a hepatic cell line and its levels in blood are associated with lung disease in a cohort of patients with different AAT serum levels. +circRNA target 35698314 hsa-mir-1290 Pre-Eclampsia CONCLUSION: Hsa_circ_000872 can regulate LHX6 by adsorbing miR-1290 to inhibit PE progression, thus establishing hsa_circ_000872 as a potential target for predicting and treating PE. +other 35698305 hsa-mir-4262 Colorectal Neoplasms CONCLUSION: Hsa_circ_0001550 facilitated CRC progression by binding to miR-4262 to positively regulate NUCKS1 abundance. +other 35697826 hsa-mir-125a Chronic Rhinosinusitis With Nasal Polyps In summary, the constructed novel MIAT/miR-125a/IRF4 axis may play a critical role in the development and progression of CRSwNP. +other 35697826 hsa-mir-125a Nasal Polyps In summary, the constructed novel MIAT/miR-125a/IRF4 axis may play a critical role in the development and progression of CRSwNP. +other 35697130 hsa-mir-499 Myocardial Ischemia Further miRNA microarray and bioinformatics analysis revealed that miR-499 was significantly down-regulated, while PTEN was remarkably upregulated after Tan IIA administration post-MI. +lncRNA target 35696757 hsa-mir-363 Glioma The changes in the target microRNA-363 sequence were standardized to identify glioma. +lncRNA target 35696408 hsa-mir-212 Diarrhea, Bacterial coli F18 susceptibility via histone H4 modifications or miR-212/FUT3 axis, which will provide theoretical guidance to develop novel strategies for combating bacterial diarrhea in piglets. +transcription factor target 35696095 hsa-mir-143 Diabetes Mellitus In conclusion, acarbose reduces VSMC migration and proliferation via upregulating miR-143 to inhibit Ras-related signaling, and potentially prevention of atherosclerosis. +transcription factor target 35696058 hsa-mir-17 Colonic Neoplasms 5p facilitated malignant progression of colon cancer through targeting CADM2 at a post-transcriptional level. +genetics_overexpression_promote 35695668 hsa-mir-1179 Pancreatic Carcinoma Overexpression of both GAS8-AS1 and miR-1179 inhibited PC cell migration and invasion. +other 35695667 hsa-mir-671 Carcinoma, Hepatocellular 5p fostered the proliferation, migration and invasion of HCC cells by restraining ALDH2. +other 35695665 hsa-mir-21 Uterine Cervical Neoplasms CCK-8 cell proliferation analysis and cell apoptosis analysis were applied to study the roles of MCM3AP-AS1, miR-21, and PTEN in regulating cell proliferation and apoptosis in CSCC. Therefore, MCM3AP-AS1 may regulate the miR-21/PTEN axis to regulate CSCC cell proliferation and apoptosis. +genetics_overexpression_promote 35695664 hsa-mir-505 Endometrial Neoplasms In EC cells, circRIMS overexpression decreased miR-505 expression and increased miR-505 gene methylation. +genetics_knock down_promote 35695663 hsa-mir-137 Stomach Neoplasms The gain/loss-of-function indicates that miR-137 regulates the proliferation, apoptosis, migration and epithelial-mesenchymal transition of GC cells. +genetics_knock down_promote 35695651 hsa-mir-29b Glioma circRNA_104948 could regulate the proliferation/apoptosis of astrocytes through miR-29b-3p/DNMT3B/MTSS1 signaling, and the biological behavior changes induced by glioma-Exo were reversed by miR-29b-3p mimics; upregulated cell growth caused by miR-29b-3p inhibitors was abrogated by the knockdown of DNMT3B; the effects induced by miR-29b-3p mimics were abolished by the overexpression of DNMT3B. Our findings revealed the important roles of circRNA_104948 on the development of glioma, and circRNA_104948/miR-29b-3p/MTSS1/DNMT3B pathway may be a potential candidate for the target therapy of glioma patients. +genetics_overexpression_promote 35695612 hsa-mir-1285 Stomach Neoplasms Overexpressing miR-1285 restrained GC cell multiplication and accelerated apoptosis, whereas suppressing miR-1285 facilitated cell growth and restrained apoptosis. +circulation_biomarker_diagnosis_up 35695610 hsa-mir-21 Leukemia, Myeloid, Acute CONCLUSION: In conclusion, SCIRT was downregulated in AML and it sponged miR-21 in cytoplasm to increase the chemosensitivity to Dox. +genetics_knock down_suppress 35695608 hsa-mir-98 Breast Neoplasms In addition, LINC01287 knockdown and miR-98 overexpression significantly stagnated progression of BC cells. +genetics_overexpression_promote 35695605 hsa-mir-124 Carcinoma, Hepatocellular In addition, miR-124 overexpression decreased HCC cell proliferation, while DSCAM-AS1 increased HCC cell proliferation. +other 35695486 hsa-mir-532 Mesothelioma, Malignant 5p for discriminating MPM from HDs were 85.9% and 59.1%, 95.1% and 62.5%, 87.1% and 79.2%, 82.2% and 58.3%, and 69.3% and 82.6%, respectively. +other 35695486 hsa-mir-29c Mesothelioma, Malignant 5p for discriminating MPM from HDs were 85.9% and 59.1%, 95.1% and 62.5%, 87.1% and 79.2%, 82.2% and 58.3%, and 69.3% and 82.6%, respectively. +other 35695486 hsa-mir-484 Mesothelioma, Malignant 5p for discriminating MPM from HDs were 85.9% and 59.1%, 95.1% and 62.5%, 87.1% and 79.2%, 82.2% and 58.3%, and 69.3% and 82.6%, respectively. +other 35695486 hsa-mir-125a Mesothelioma, Malignant 5p for discriminating MPM from HDs were 85.9% and 59.1%, 95.1% and 62.5%, 87.1% and 79.2%, 82.2% and 58.3%, and 69.3% and 82.6%, respectively. +other 35695486 hsa-mir-20a Mesothelioma, Malignant 5p for discriminating MPM from HDs were 85.9% and 59.1%, 95.1% and 62.5%, 87.1% and 79.2%, 82.2% and 58.3%, and 69.3% and 82.6%, respectively. +circulation_biomarker_diagnosis_ns 35695478 hsa-mir-375 Prostatic Neoplasms Here we describe how a ligation-free version of this technique performed in a single tube can be used to improve the limit of detection for microRNA-375, an important blood biomarker for prostate cancer. +circulation_biomarker_diagnosis_up 35695424 hsa-mir-17 Retinal Diseases 5p/HIF-1alpha/VEGF signaling, and thus has therapeutic potential for the prevention and treatment of ROP.Abbreviations: BSA, bovine serum albumin; COX2, cyclooxygenase 2; ECM, endothelial cell medium; FBS, fetal bovine serum; HDAC, histone deacetylase; HIF-1, hypoxia-inducible factor 1; HRMEC, human retinal microvascular endothelial cell; Hsp70, heat shock protein; IB4, isolectin B4; ICAM-1, intercellular adhesion molecule 1; IL-1beta/6, interleukin 1 beta/6; MAPK, mitogen-activated protein kinase; MCP-1, monocyte chemoattractant protein 1; miRNA, microRNA; MMP, matrix metalloproteinase; mTOR, mammalian target of rapamycin; NF-kappaB, nuclear factor-kappa B; OIR, oxygen-induced retinopathy; PBS, phosphate-buffered saline; PCNA, proliferating cell nuclear antigen; PI3K, phosphatidylinositol +circulation_biomarker_diagnosis_up 35695424 hsa-mir-17 osteogenesis imperfecta type 1 5p/HIF-1alpha/VEGF signaling, and thus has therapeutic potential for the prevention and treatment of ROP.Abbreviations: BSA, bovine serum albumin; COX2, cyclooxygenase 2; ECM, endothelial cell medium; FBS, fetal bovine serum; HDAC, histone deacetylase; HIF-1, hypoxia-inducible factor 1; HRMEC, human retinal microvascular endothelial cell; Hsp70, heat shock protein; IB4, isolectin B4; ICAM-1, intercellular adhesion molecule 1; IL-1beta/6, interleukin 1 beta/6; MAPK, mitogen-activated protein kinase; MCP-1, monocyte chemoattractant protein 1; miRNA, microRNA; MMP, matrix metalloproteinase; mTOR, mammalian target of rapamycin; NF-kappaB, nuclear factor-kappa B; OIR, oxygen-induced retinopathy; PBS, phosphate-buffered saline; PCNA, proliferating cell nuclear antigen; PI3K, phosphatidylinositol +circulation_biomarker_diagnosis_up 35695424 hsa-mir-17 Retinopathy of Prematurity 5p/HIF-1alpha/VEGF signaling, and thus has therapeutic potential for the prevention and treatment of ROP.Abbreviations: BSA, bovine serum albumin; COX2, cyclooxygenase 2; ECM, endothelial cell medium; FBS, fetal bovine serum; HDAC, histone deacetylase; HIF-1, hypoxia-inducible factor 1; HRMEC, human retinal microvascular endothelial cell; Hsp70, heat shock protein; IB4, isolectin B4; ICAM-1, intercellular adhesion molecule 1; IL-1beta/6, interleukin 1 beta/6; MAPK, mitogen-activated protein kinase; MCP-1, monocyte chemoattractant protein 1; miRNA, microRNA; MMP, matrix metalloproteinase; mTOR, mammalian target of rapamycin; NF-kappaB, nuclear factor-kappa B; OIR, oxygen-induced retinopathy; PBS, phosphate-buffered saline; PCNA, proliferating cell nuclear antigen; PI3K, phosphatidylinositol +circulation_biomarker_diagnosis_up 35695424 hsa-mir-17 Hypertrophy, Right Ventricular 5p/HIF-1alpha/VEGF signaling, and thus has therapeutic potential for the prevention and treatment of ROP.Abbreviations: BSA, bovine serum albumin; COX2, cyclooxygenase 2; ECM, endothelial cell medium; FBS, fetal bovine serum; HDAC, histone deacetylase; HIF-1, hypoxia-inducible factor 1; HRMEC, human retinal microvascular endothelial cell; Hsp70, heat shock protein; IB4, isolectin B4; ICAM-1, intercellular adhesion molecule 1; IL-1beta/6, interleukin 1 beta/6; MAPK, mitogen-activated protein kinase; MCP-1, monocyte chemoattractant protein 1; miRNA, microRNA; MMP, matrix metalloproteinase; mTOR, mammalian target of rapamycin; NF-kappaB, nuclear factor-kappa B; OIR, oxygen-induced retinopathy; PBS, phosphate-buffered saline; PCNA, proliferating cell nuclear antigen; PI3K, phosphatidylinositol +circulation_biomarker_diagnosis_up 35695424 hsa-mir-17 Benign Paroxysmal Positional Vertigo 5p/HIF-1alpha/VEGF signaling, and thus has therapeutic potential for the prevention and treatment of ROP.Abbreviations: BSA, bovine serum albumin; COX2, cyclooxygenase 2; ECM, endothelial cell medium; FBS, fetal bovine serum; HDAC, histone deacetylase; HIF-1, hypoxia-inducible factor 1; HRMEC, human retinal microvascular endothelial cell; Hsp70, heat shock protein; IB4, isolectin B4; ICAM-1, intercellular adhesion molecule 1; IL-1beta/6, interleukin 1 beta/6; MAPK, mitogen-activated protein kinase; MCP-1, monocyte chemoattractant protein 1; miRNA, microRNA; MMP, matrix metalloproteinase; mTOR, mammalian target of rapamycin; NF-kappaB, nuclear factor-kappa B; OIR, oxygen-induced retinopathy; PBS, phosphate-buffered saline; PCNA, proliferating cell nuclear antigen; PI3K, phosphatidylinositol +circulation_biomarker_diagnosis_up 35695424 hsa-mir-17 Retinal Neovascularization 5p/HIF-1alpha/VEGF signaling, and thus has therapeutic potential for the prevention and treatment of ROP.Abbreviations: BSA, bovine serum albumin; COX2, cyclooxygenase 2; ECM, endothelial cell medium; FBS, fetal bovine serum; HDAC, histone deacetylase; HIF-1, hypoxia-inducible factor 1; HRMEC, human retinal microvascular endothelial cell; Hsp70, heat shock protein; IB4, isolectin B4; ICAM-1, intercellular adhesion molecule 1; IL-1beta/6, interleukin 1 beta/6; MAPK, mitogen-activated protein kinase; MCP-1, monocyte chemoattractant protein 1; miRNA, microRNA; MMP, matrix metalloproteinase; mTOR, mammalian target of rapamycin; NF-kappaB, nuclear factor-kappa B; OIR, oxygen-induced retinopathy; PBS, phosphate-buffered saline; PCNA, proliferating cell nuclear antigen; PI3K, phosphatidylinositol +other 35695264 hsa-mir-9 Heart Arrest 3p are peaking 48 hours following cardiac arrest. +lncRNA target 35695254 hsa-mir-448 Colorectal Neoplasms Knocking down of nuclear paraspeckle assembly transcript 1 can suppress colorectal cancer proliferation and invasion, and caused a reduction of ZEB1 expression and an increase of miR-448 expression. Conclusion: Our result demonstrated that long noncoding RNA nuclear paraspeckle assembly transcript 1 promotes proliferation and invasion of colorectal cancer by targeting miR-448 to promote the expression of ZEB1, which may play a significant role in the tumorigenesis of colorectal cancer. +transcription factor target 35695083 hsa-mir-21 Hypoxia-Ischemia, Brain CONCLUSION: DZ enhanced miR-21 level and inhibited PDCD4 level via PI3K/AKT pathway to resisted HIE. +circulation_biomarker_prognosis_up 35694659 hsa-mir-200b Shock, Cardiogenic Future studies are required to delineate the impact of serum miRNA-200b levels as a prognostic marker in patients with acute CS and pVAD unloading. +exosome 35693981 hsa-mir-579 Osteosarcoma Additionally, the promoting function of exosomal CTCF-mediated IGF2-AS/miR +other 35693941 hsa-mir-101 Carcinoma, Hepatocellular Then, we constructed a ceRNA network consisting of MELK, miR3p, and two lncRNAs (SNHG1 and SNHG6) after evaluating the expression and impact on prognosis in HCC of these RNAs. +other 35693719 hsa-mir-142 Kidney Neoplasms As a natural vector of miR3p, RCSC-sEVs return to the kidney cells and interfered with the expression of ERp44, inducing ERS and ultimately leading to apoptosis of normal renal cells and renal function impairment. +other 35693619 hsa-mir-145 Cardiomegaly In hypertrophic cardiomyocytes, after up-regulating the expression of miR-145, the relative messenger ribonucleic acid (mRNA) and protein expressions of atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) induced by PE decreased. CONCLUSIONS: The lncRNA ROR can promote the expression of HAX-1 by competitive binding with miR-145, so as to promote the pathophysiological process of myocardial hypertrophy. +genetics_GWAS 35693293 hsa-mir-494 Carcinoma, Non-Small-Cell Lung 3p was significantly elevated in plasma sampled at disease progression compared to plasma sampled at treatment baseline in a cohort of 21 EGFR T790M-mutation positive NSCLC patients receiving osimertinib. +other 35693096 hsa-mir-137 Stomach Neoplasms In addition, according to the lncRNA/miRNA/mRNA regulatory relationships among the 43 ceRNAs, we identified four axes that might play important roles in the progression of GC and investigated the potential mechanism of the most promising axis (POU6F2-AS2/hsa-mir-137/OPCML) in promoting the proliferation and invasiveness of GC. +circRNA target 35693080 hsa-mir-491 Esophageal Squamous Cell Carcinoma In conclusion, hsa_circ_0001741 promotes ESCC stemness, invasion, and migration by sponging tumor suppressor miR5p to upregulate NOTCH3 expression. +other 35693013 hsa-mir-17 Adenocarcinoma of Lung According to the results of our study, the ferroptosis-related ceRNA HCP5 /hsa-miR5p/HOXA7 axis may contribute to the development of BNM in LUAD patients. +other 35693013 hsa-mir-17 Thyroid Cancer, Papillary According to the results of our study, the ferroptosis-related ceRNA HCP5 /hsa-miR5p/HOXA7 axis may contribute to the development of BNM in LUAD patients. +circulation_biomarker_diagnosis_up 35692876 hsa-mir-144 Crohn Disease These findings suggested that circulating exosomal miR +target gene 35692754 hsa-mir-485 Osteosarcoma Long Intergenic Noncoding RNA00265 Enhances Cell Viability and Metastasis via Targeting miR-485-5p/USP22 Axis in Osteosarcoma. +other 35692583 hsa-mir-28 lung squamous cell carcinoma 3p/IL1B regulatory axis for LUSC. +circulation_biomarker_diagnosis_up 35692504 hsa-mir-635 Stomach Neoplasms In addition, AC restrained gastric cancer proliferation and migration ability and induced endoplasmic reticulum stress by upregulating miR-635 expression. CONCLUSION: AC suppressed gastric cancer progression and induced endoplasmic reticulum stress via the miR-635/HMGA1 axis, providing a valuable drug against gastric cancer. +genetics_overexpression_suppress 35692501 hsa-mir-214 Squamous Cell Carcinoma of Head and Neck Moreover, to further determine the impacts of miR-214 and ULK1 on oral cancer cell growth after chemotherapy, the two were overexpressed or silenced in CAL-27 cells after transfection. +other 35692373 hsa-mir-22 Iron Metabolism Disorders The current study was aimed at exploring the function and mechanism of MIR22HG in I/R injury. +genetics_knock down_suppress 35692373 hsa-mir-9 Cardiomyopathies In summary, MIR22HG knockdown alleviates myocardial injury through the miR3p/SH2B3 axis. +genetics_knock down_suppress 35692373 hsa-mir-9 Myocardial Infarction In summary, MIR22HG knockdown alleviates myocardial injury through the miR +genetics_knock down_promote 35692373 hsa-mir-22 Myocardial Infarction In summary, MIR22HG knockdown alleviates myocardial injury through the miR +genetics_knock down_suppress 35692373 hsa-mir-22 Cardiomyopathies In summary, MIR22HG knockdown alleviates myocardial injury through the miR3p/SH2B3 axis. +exosome 35691812 hsa-mir-603 Pancreatitis CONCLUSION: Exosome-derived miR-603, miR-548ad-5p, miR +exosome 35691812 hsa-mir-548ad Pancreatitis CONCLUSION: Exosome-derived miR-603, miR-548ad-5p, miR +exosome 35691812 hsa-mir-122 Pancreatitis CONCLUSION: Exosome-derived miR-603, miR-548ad-5p, miR +exosome 35691812 hsa-mir-215 Pancreatitis CONCLUSION: Exosome-derived miR-603, miR-548ad-5p, miR +exosome 35691812 hsa-mir-4477a Pancreatitis CONCLUSION: Exosome-derived miR-603, miR-548ad-5p, miR +exosome 35691812 hsa-mir-583 Pancreatitis CONCLUSION: Exosome-derived miR-603, miR-548ad-5p, miR +lncRNA target 35691339 hsa-mir-134 Osteoporosis 5p/Itgb1/MAPK pathway might be a potential target for osteoporosis therapy. +lncRNA target 35691099 hsa-mir-194 Colonic Neoplasms 3p could overcome DCT resistance in CC cells through negatively regulating KLK10. +circulation_biomarker_prognosis_ns 35691029 hsa-mir-21 Primary Gastrointestinal Diffuse Large B-Cell Lymphoma RESULTS: Compared with healthy controls, serum miR-21 levels were significantly elevated in the PGI-DLBCL patients (n=156). +exosome 35690961 hsa-mir-7 Small Cell Lung Carcinoma The present study revealed that Myc regulates hsa-miR-7, hsa-miR-9, hsa-miR-125b, hsa-miR-181a_2, hsa-miR-455, hsa-miR-642, and hsa-miR-4417 expressions in SCLC cell lines, not only in cellular but also in exosomal content. +exosome 35690961 hsa-mir-181a Small Cell Lung Carcinoma The present study revealed that Myc regulates hsa-miR-7, hsa-miR-9, hsa-miR-125b, hsa-miR-181a_2, hsa-miR-455, hsa-miR-642, and hsa-miR-4417 expressions in SCLC cell lines, not only in cellular but also in exosomal content. +exosome 35690961 hsa-mir-9 Small Cell Lung Carcinoma The present study revealed that Myc regulates hsa-miR-7, hsa-miR-9, hsa-miR-125b, hsa-miR-181a_2, hsa-miR-455, hsa-miR-642, and hsa-miR-4417 expressions in SCLC cell lines, not only in cellular but also in exosomal content. +exosome 35690961 hsa-mir-642 Small Cell Lung Carcinoma The present study revealed that Myc regulates hsa-miR-7, hsa-miR-9, hsa-miR-125b, hsa-miR-181a_2, hsa-miR-455, hsa-miR-642, and hsa-miR-4417 expressions in SCLC cell lines, not only in cellular but also in exosomal content. +exosome 35690961 hsa-mir-4417 Small Cell Lung Carcinoma The present study revealed that Myc regulates hsa-miR-7, hsa-miR-9, hsa-miR-125b, hsa-miR-181a_2, hsa-miR-455, hsa-miR-642, and hsa-miR-4417 expressions in SCLC cell lines, not only in cellular but also in exosomal content. +exosome 35690961 hsa-mir-125b Small Cell Lung Carcinoma The present study revealed that Myc regulates hsa-miR-7, hsa-miR-9, hsa-miR-125b, hsa-miR-181a_2, hsa-miR-455, hsa-miR-642, and hsa-miR-4417 expressions in SCLC cell lines, not only in cellular but also in exosomal content. +exosome 35690961 hsa-mir-455 Small Cell Lung Carcinoma The present study revealed that Myc regulates hsa-miR-7, hsa-miR-9, hsa-miR-125b, hsa-miR-181a_2, hsa-miR-455, hsa-miR-642, and hsa-miR-4417 expressions in SCLC cell lines, not only in cellular but also in exosomal content. +circulation_biomarker_prognosis_up 35690861 hsa-mir-654 Heart Failure 5p for the first time as a novel biomarker of HF, but also developed a novel 2-circulating miRNA model with promising potentials for diagnosis and prognosis of HF patients, and in association with therapeutic effects as well. +lncRNA target 35690612 hsa-mir-27a Squamous Cell Carcinoma of Head and Neck Mechanistically, a dual-luciferase reporter assay, FISH, RIP, RNA pull-down, RNA-seq, and western blot experiments were employed and found that circRFWD3 served as a miRNAs sponge for miR-27a/27b, leading to the upregulation of PPARgamma, and then promoted HNSCC metastasis via NF-kappaB/MMP13 pathway. +circulation_biomarker_diagnosis_ns 35690607 hsa-mir-96 Scoliosis, Adolescent Our results showed significantly higher plasma levels of miR +circulation_biomarker_diagnosis_ns 35690607 hsa-mir-96 idiopathic scoliosis Our results showed significantly higher plasma levels of miR +circulation_biomarker_diagnosis_ns 35690607 hsa-mir-96 Bone Diseases, Metabolic Our results showed significantly higher plasma levels of miR +other 35690602 hsa-mir-129 Migraine Disorders Lipid-associated miRs -19a, -129, -24, and 3p are differentially expressed following macrophage polarisation and lipid supplementation and are further regulated during MAP infection. +other 35690602 hsa-mir-24 Migraine Disorders Lipid-associated miRs -19a, -129, -24, and 3p are differentially expressed following macrophage polarisation and lipid supplementation and are further regulated during MAP infection. +other 35690602 hsa-mir-19a Migraine Disorders Lipid-associated miRs -19a, -129, -24, and 3p are differentially expressed following macrophage polarisation and lipid supplementation and are further regulated during MAP infection. +lncRNA target 35690295 hsa-mir-184 Macular Degeneration Taken together, miR-184 attenuates retinal cell damage induced by severe AMD pathologies through suppressing hypoxia, angiogenesis and apoptosis. +genetics_GWAS 35690283 hsa-mir-149 Precursor Cell Lymphoblastic Leukemia-Lymphoma Similarly, miR-149 (rs2292832) was positively associated with ALL according to the codominant and dominant genetic models. +transcription factor target 35690236 hsa-mir-146a Diabetes Mellitus Luminex assay was performed on conditioned media at 6- and 20-h post-wounding in miR-146a mimic/inhibitor transfected normal and diabetic cultured LECs. +circulation_biomarker_diagnosis_ns 35690140 hsa-mir-493 Segmental Vitiligo Hence, circulating exosomal miR +exosome 35689956 hsa-mir-129 Pulmonary Fibrosis Furthermore, the in vivo experiment confirmed that the exosomes of M2 macrophages could carry miR +lncRNA target 35689751 hsa-mir-148b Adrenocorticotropic hormone deficiency The expression levels of circ_0021001 and GREM1 were increased, and that of miR-148b-3p was decreased in IA tissues and HUASMCs. Circ_0021001 silencing could suppress cell growth and induce apoptosis of HUASMCs partially through modulating the miR-148b-3p/GREM1, presented circ_0021001 as a promising therapeutic target for IA. +other 35689735 hsa-mir-146a Fetal Growth Retardation The alleles related to reduced miRNA-146a (C) and ADIPOQ (A) activity showed increased frequency in SGA. CONCLUSIONS: The miR-146a (rs2910164) and ADIPOQ (rs182052) allelic variants are related to birth weight in SGA and may predict health-related outcomes, such as PCOS and obesity risk. +other 35689735 hsa-mir-146a Obesity CONCLUSIONS: The miR-146a (rs2910164) and ADIPOQ (rs182052) allelic variants are related to birth weight in SGA and may predict health-related outcomes, such as PCOS and obesity risk. +lncRNA target 35689735 hsa-mir-146a Polycystic Ovary Syndrome The mature miR-146a targets 319 genes, been the CXCR4, TMEM167A and IF144L common targets and contributes to PCOS. CONCLUSIONS: The miR-146a (rs2910164) and ADIPOQ (rs182052) allelic variants are related to birth weight in SGA and may predict health-related outcomes, such as PCOS and obesity risk. +circRNA target 35689709 hsa-mir-24 Polycystic Ovary Syndrome 3p/MAP2K6, which provided a promising therapeutic target for PCOS. +lncRNA target 35689522 hsa-mir-199a Squamous Cell Carcinoma of Head and Neck Importantly, CUR-NEs cloud effectively counteract the influence on cell proliferation of OSCC cells and the proliferative phases of cell cycle caused by miR-199a inhibitor a time-dependent manner. +exosome 35689381 hsa-mir-124 Parkinson Disease Our findings reveal a novel promising therapeutic application of small extracellular vesicles as delivery agents for miR3p in the context of Parkinson's disease. +other 35689264 hsa-mir-181a Osteoarthritis CONCLUSIONS: Conclusively, Gm37494 elevated GABRA1 expression by binding to miR-181a-5p, thus ameliorating OA-induced chondrocyte damage. +other 35689189 hsa-mir-485 Reperfusion Injury, Cerebral Ischemia 5p may be associated with pathogenic alteration of the oxidative respiratory chain and energy metabolism in preterm infants with SAE. +other 35689189 hsa-mir-485 Sepsis-Associated Encephalopathy 5p may be associated with pathogenic alteration of the oxidative respiratory chain and energy metabolism in preterm infants with SAE. +other 35689189 hsa-mir-1197 Reperfusion Injury, Cerebral Ischemia 5p may be associated with pathogenic alteration of the oxidative respiratory chain and energy metabolism in preterm infants with SAE. +other 35689189 hsa-mir-1197 Sepsis-Associated Encephalopathy 5p may be associated with pathogenic alteration of the oxidative respiratory chain and energy metabolism in preterm infants with SAE. +genetics_overexpression_promote 35688263 hsa-mir-129-2 Triple Negative Breast Neoplasms DARS-AS1 overexpression significantly enhanced the migration and invasion of TNBC tumors by inhibiting miR2-3p and upregulated CDK1 to activate the NF-kappaB/STAT3 signaling pathway both in vitro and in vivo. +circRNA target 35687903 hsa-mir-24 Abortion, Habitual 3p/TJP1 axis is involved in the occurrence and progression of RSA and may be a promising therapeutic target in RSA. +circRNA target 35687899 hsa-mir-1276 Ovarian Neoplasms CONCLUSION: Circ_0063804 promoted OC cells proliferation and resistance to cisplatin by enhancing CLU expression via sponging miR-1276. +genetics_overexpression_promote 35687898 hsa-mir-122 Urinary Bladder Neoplasms We picked up miRNA miR-3122, which substantially interacted with NEAT1.1, and found that histone H3K79me3 was reduced in bladder cancer T24, BIU-87 and EJ-1 cells after miR-3122 overexpression, and rescued by NEAT1.1 additional compensation. Taken together, we demonstrated that NEAT1.1 weakened the effect of miR-3122 on H3K79me3 suppression in bladder cancer. +exosome 35687301 hsa-mir-34a Insulin Resistance The in vitro and in vivo functional experiments revealed that MSC secreted exosomal miR-34a-5p and ameliorated IIRI through METTL3/IGF2BP3-mediated m(6)A modification of pre-miR-34A. +genetics_overexpression_promote 35687299 hsa-mir-544 Inflammation Also, either miR3p inhibition or TLR4 overexpression weakened circ-Ncam2 silencing-mediated effects on LPS-induced BV2 cell activation and inflammation. +lncRNA target 35687299 hsa-mir-544 Spinal Cord Injuries circ-Ncam2 silencing lowered LPS-induced microglia activation and neuronal apoptosis via blocking the TLR4/NF-kappaB pathway through acting as a miR3p sponge, suggesting that circ-Ncam2 may be involved in secondary SCI. +other 35687145 hsa-mir-339 Nephritis The purpose of this study was to investigate the role of miR5p in lipopolysaccharide (LPS)-induced nephritis injury in vitro. +other 35687145 hsa-mir-339 Leukemia, Myelogenous, Chronic, BCR-ABL Positive However, the role of miR5p in CGN remains unclear. +genetics_GWAS 35687049 hsa-mir-616 Squamous Cell Carcinoma of Head and Neck In summary, our findings revealed that the risk SNP rs3113503 G > C in LINC01614 altered the binding to miR3p, which led to increased LINC01614 expression and promoted HNSCC progression by activating the PI3K/AKT signaling pathway. +lncRNA target 35686740 hsa-mir-944 Osteoarthritis In our study, LEMD1-AS1 and post-GPI attachment to protein (PGAP1) were lowly expressed, but miR-944 was highly expressed both in OA tissues and in Lipopolysaccharide (LPS) -treated chondrocytes detected by qRT-PCR. To conclude, the LEMD1-AS1/miR-944/PGAP1 axis may be a novel therapeutic candidate to target in OA treatment. +genetics_knock down_suppress 35686503 hsa-mir-129-2 Stomach Neoplasms CONCLUSIONS: Circ_0081143 knockdown weakened DR resistance and blocked the development of DR-resistant GC by regulating the miR +lncRNA target 35686454 hsa-mir-96 Myocardial Infarction Collectively, USP7 upregulated SOX9 expression through deubiquitination, and SOX9 suppressed miR +lncRNA target 35686454 hsa-mir-96 Sepsis Collectively, USP7 upregulated SOX9 expression through deubiquitination, and SOX9 suppressed miR +other 35686336 hsa-mir-218 Prostatic Neoplasms 3p were downregulated in human PCa cells compared with normal prostate epithelial cells. +other 35686336 hsa-mir-483 Prostatic Neoplasms 3p were downregulated in human PCa cells compared with normal prostate epithelial cells. +epigenetics 35686306 hsa-mir-124-2 Uterine Cervical Dysplasia CONCLUSIONS: Compared with HPV16/18 genotyping, the FAM19A4/miR124-2 methylation test detects nonproductive, transforming CIN2/3 lesions with high specificity in women aged <30 years, providing clinicians supportive information about the need for treatment of CIN2/3 in young HPV-positive women. +epigenetics 35686306 hsa-mir-124-2 Papillomavirus Infections CONCLUSIONS: Compared with HPV16/18 genotyping, the FAM19A4/miR124-2 methylation test detects nonproductive, transforming CIN2/3 lesions with high specificity in women aged <30 years, providing clinicians supportive information about the need for treatment of CIN2/3 in young HPV-positive women. +other 35686126 hsa-mir-125a Arthritis, Rheumatoid Furthermore, circNUP214 functioned as a ceRNA for miR-125a-3p in RA patients. +other 35685465 hsa-mir-743a Cardiotoxicity In addition, the expression profile of miR-743a and Mob1b are consistent with skeletal muscle recovery after Cardiotoxin (CTX) injury. +circulation_biomarker_diagnosis_ns 35685351 hsa-mir-92a Carcinoma, Non-Small-Cell Lung CONCLUSION: By assessing the expression and functional profile of DEmiRs in the plasma exosomes of NSCLC patients after radiotherapy, miR-92a-3p was identified as a promising target affecting radiotherapy outcomes through the Ras signaling pathway. +other 35683791 hsa-mir-200c Breast Neoplasms 3p) were suggested to be important clinical biomarkers for evaluating therapeutic outcomes of breast cancer-related PTT. +other 35683791 hsa-mir-150 Breast Neoplasms 3p) were suggested to be important clinical biomarkers for evaluating therapeutic outcomes of breast cancer-related PTT. +other 35683791 hsa-mir-9 Breast Neoplasms 3p) were suggested to be important clinical biomarkers for evaluating therapeutic outcomes of breast cancer-related PTT. +other 35683791 hsa-mir-125a Breast Neoplasms 3p) were suggested to be important clinical biomarkers for evaluating therapeutic outcomes of breast cancer-related PTT. +other 35683791 hsa-mir-34a Breast Neoplasms 3p) were suggested to be important clinical biomarkers for evaluating therapeutic outcomes of breast cancer-related PTT. +other 35683791 hsa-mir-148b Breast Neoplasms 3p) were suggested to be important clinical biomarkers for evaluating therapeutic outcomes of breast cancer-related PTT. +other 35683791 hsa-mir-133a Breast Neoplasms 3p) were suggested to be important clinical biomarkers for evaluating therapeutic outcomes of breast cancer-related PTT. +circulation_biomarker_diagnosis_up 35683018 hsa-mir-153 Prostatic Neoplasms Being upregulated in high GS human PC, miR-153 could be proposed as a circulating biomarker for PC diagnosis. +other 35682971 hsa-mir-21 Colorectal Neoplasms Our findings suggest that a combination of coffee compounds reduces early-stage colon carcinogenesis by the modulation of miR-21a-5p expression, highlighting the importance of coffee intake to prevent CRC. +lncRNA target 35682879 hsa-mir-224 Osteosarcoma A mechanistic study showed that circSRSF4 can be used as an miR-224 sponge to up-regulate the expression of Rac1, thereby promoting the development of osteosarcoma. (4) Conclusions: CircSRSF4 acting as a ceRNA promotes the malignant behavior of osteosarcoma through the circSRSF4/miR-224/Rac1 axis, which provides a new theoretical basis for the clinical prevention and treatment of osteosarcoma and the study of related markers and intervention targets. +other 35682732 hsa-mir-205 Cervical Intraepithelial Neoplasia The expression of miR5p was lower in both CIN and cancer samples compared to normal samples. +other 35682732 hsa-mir-205 Uterine Cervical Neoplasms The expression of miR5p was lower in both CIN and cancer samples compared to normal samples. +other 35682716 hsa-mir-378f Stomach Neoplasms Hsa-miR-378f was identified as showing a statistically significant correlation in GC patients receiving XELOX chemotherapy according to the analysis of differentially expressed (DE) miRNAs. +lncRNA target 35682670 hsa-mir-10b Glioblastoma aryl-1H-imidazole scaffold, used in combination with a miRNA inhibitor molecule targeting the oncomiRNA miR-10b-5p. +other 35682668 hsa-mir-143 Obesity 3p (rs = -0.308). +other 35682668 hsa-mir-100 Obesity 3p (rs = -0.308). +other 35682668 hsa-mir-22 Obesity 3p (rs = -0.308). +other 35682668 hsa-mir-495 Obesity 3p (rs = -0.308). +other 35682668 hsa-mir-18a Obesity 3p (rs = -0.308). +other 35682668 hsa-mir-576 Obesity 3p (rs = -0.308). +other 35682668 hsa-mir-18b Obesity 3p (rs = -0.308). +other 35682646 hsa-mir-21 Cardiotoxicity Additionally, cardiac mirR-21 and miR-26a were assessed. +other 35682646 hsa-mir-26a Cardiotoxicity Additionally, cardiac mirR-21 and miR-26a were assessed. +lncRNA target 35682592 hsa-mir-126 Alzheimer Disease However, 158 microRNAs were significantly dysregulated in AD NMV compared to controls, some of which were associated with BBB dysfunction, including miR-210, miR-20b-5p and miR5p. +lncRNA target 35682592 hsa-mir-210 Alzheimer Disease However, 158 microRNAs were significantly dysregulated in AD NMV compared to controls, some of which were associated with BBB dysfunction, including miR-210, miR-20b-5p and miR5p. +lncRNA target 35682548 hsa-mir-375 Neuroblastoma These results indicate that IH stress increases levels of DBH and PNMT via the inhibition of miRmediated mRNA degradation, potentially playing a role in the emergence of hypertension in SAS patients. +circulation_biomarker_diagnosis_up 35682544 hsa-mir-451a Endometriosis BACKGROUND: miR-451a can function as a tumor suppresser and has been shown to be elevated in both endometriotic lesion tissue and serum from women with endometriosis. +lncRNA target 35682544 hsa-mir-25 Endometriosis 3p and PTEN, while in vitro cell transfection studies suggest that miR-451a may regulate PTEN expression via modulating miR +lncRNA target 35681793 hsa-mir-378a Prostatic Neoplasms Herein, we first demonstrated how miR-378 exerts anti-prostate cancer (PCa) actions by influencing multiple target genes, including KLK2, KLK4, KLK6, and KLK14, which are implicated in PCa development, cell proliferation, and cell survival. The results showed high significance after EPA induced tumor cells containing higher expression levels of miR-378, and led the PCa cells having low cell viabilities, and they progressed to apoptosis when compared with normal prostate cells (p < 0.001). +lncRNA target 35681793 hsa-mir-378 Prostatic Neoplasms Herein, we first demonstrated how miR-378 exerts anti-prostate cancer (PCa) actions by influencing multiple target genes, including KLK2, KLK4, KLK6, and KLK14, which are implicated in PCa development, cell proliferation, and cell survival. The results showed high significance after EPA induced tumor cells containing higher expression levels of miR-378, and led the PCa cells having low cell viabilities, and they progressed to apoptosis when compared with normal prostate cells (p < 0.001). +other 35681658 hsa-mir-152 Thyroid Cancer, Papillary 5p (FDR < 0.05; |fold change (FC)| >/= 1.5). +other 35681658 hsa-mir-551b Thyroid Cancer, Papillary 5p (FDR < 0.05; |fold change (FC)| >/= 1.5). +other 35681658 hsa-mir-7 Thyroid Cancer, Papillary 5p (FDR < 0.05; |fold change (FC)| >/= 1.5). +other 35681658 hsa-mir-146b Thyroid Cancer, Papillary 5p (FDR < 0.05; |fold change (FC)| >/= 1.5). +other 35681658 hsa-mir-221 Thyroid Cancer, Papillary 5p (FDR < 0.05; |fold change (FC)| >/= 1.5). +lncRNA target 35681518 hsa-let-7e Myocardial Infarction Additionally, given its involvement in modulating endothelial cell function and vascularization, altered let-7e-5p expression may constitute a therapeutic biomarker and target for ischemic heart disease. +other 35680981 hsa-mir-1273f Osteoporosis Besides, the two axes of hsa_circR_0028877/hsa-miR-1273f/CAMK2A and hsa_circR_0028877/hsa-miR-1273f/DIRAS2 conformed to be closely associated with OP. +circulation_biomarker_diagnosis_up 35680806 hsa-mir-34a Thrombocytopenia RESULTS: Among the 69 DLBCL patients, 36 patients developed thrombocytopenia after 2 cycles of R-CHOP 21 regimen for chemotherapy, the incidence was 52.17%; the level of serum IL-11 and the relative expression of miR-34a mRNA in the reduction group were significantly lower than the non reduction group (P<0.05), compared other data between groups, there was no statistical significant difference (P>0.05); after Logistic regression analysis, the results showed that the level of serum IL-11 and the relative expression of miR-34a mRNA were related to thrombocytopenia after chemotherapy in DLBCL patients, low expression of each index may be a risk factor of thrombocytopenia after chemotherapy in DLBCL patients (OR>1, P<0.05); ROC curve was drawn, and the results showed that the AUC of serum IL-11 level and miR-34a mRNA relative expression before chemotherapy alone and in combination predicted the risk of thrombocytopenia after chemotherapy in DLBCL patients were all >0.80, and the predictive value was ideal, when the cut-off value of serum IL-11 level before chemotherapy was 42.094 pg/ml, and the cut-off value of miR-34a mRNA relative expression was 3.894, the combined prediction value was the best. +circulation_biomarker_diagnosis_up 35680806 hsa-mir-34a Lymphoma, Large B-Cell, Diffuse RESULTS: Among the 69 DLBCL patients, 36 patients developed thrombocytopenia after 2 cycles of R-CHOP 21 regimen for chemotherapy, the incidence was 52.17%; the level of serum IL-11 and the relative expression of miR-34a mRNA in the reduction group were significantly lower than the non reduction group (P<0.05), compared other data between groups, there was no statistical significant difference (P>0.05); after Logistic regression analysis, the results showed that the level of serum IL-11 and the relative expression of miR-34a mRNA were related to thrombocytopenia after chemotherapy in DLBCL patients, low expression of each index may be a risk factor of thrombocytopenia after chemotherapy in DLBCL patients (OR>1, P<0.05); ROC curve was drawn, and the results showed that the AUC of serum IL-11 level and miR-34a mRNA relative expression before chemotherapy alone and in combination predicted the risk of thrombocytopenia after chemotherapy in DLBCL patients were all >0.80, and the predictive value was ideal, when the cut-off value of serum IL-11 level before chemotherapy was 42.094 pg/ml, and the cut-off value of miR-34a mRNA relative expression was 3.894, the combined prediction value was the best. +genetics_knock down_suppress 35680727 hsa-mir-1253 Nasopharyngeal Carcinoma RESULTS: CircFIP1L1 overexpression and miR-1253 knockdown repressed NPC cell proliferation, facilitated NPC cell apoptosis, and enhanced NPC radiosensitivity. +genetics_overexpression_promote 35680520 hsa-mir-122 Pediatric Obesity Overexpression of miR +genetics_knock down_promote 35680373 hsa-mir-22 Meningioma In vitro studies showed that IMAT1 promoted meningioma cell invasion through the inactivation of the Kruppel-like factor 4 (KLF4)/hsa-miR22-3p/Snai1 pathway by acting as a sponge for hsa-miR22-3p, and IMAT1 knockdown effectively restored the tumor suppressive properties of KLF4 by preserving its tumor suppressor pathway. +genetics_knock down_promote 35680372 hsa-mir-558 ankylosing spondylitis 1 In summary, our key findings demonstrated that knockdown of MALAT1 served as a potential suppressor of AS by upregulating miR-558 via the downregulation of GSDMD expression. +circRNA target 35679712 hsa-mir-291a Acute Lung Injury Therefore, our results suggested that circNCLN/miR-291a-3p/TSLP axis may be an important signaling in LPS-induced ALI and circNCLN inhibition may serve as a potential treatment of ALI. +other 35679261 hsa-mir-146a Respiratory Distress Syndrome However, the role of miR-146a-5p and TLR7 signaling in pulmonary inflammation, endothelial activation, and sepsis-associated acute respiratory distress syndrome remains unclear. Together, these data demonstrate that TLR7 activation elicits pulmonary inflammation and endothelial barrier disruption by sensing extracellular miR-146a-5p and contributes to sepsis-associated acute respiratory distress syndrome. +other 35679261 hsa-mir-146a Sepsis However, the role of miR-146a-5p and TLR7 signaling in pulmonary inflammation, endothelial activation, and sepsis-associated acute respiratory distress syndrome remains unclear. Together, these data demonstrate that TLR7 activation elicits pulmonary inflammation and endothelial barrier disruption by sensing extracellular miR-146a-5p and contributes to sepsis-associated acute respiratory distress syndrome. +genetics_knock down_suppress 35678981 hsa-mir-98 Inflammation CONCLUSIONS: SNHG14 knockdown alleviated OGD/induced N2A cell apoptosis, ER stress, inflammation and oxidative stress by depleting BCL2L13 via increasing miR +transcription factor target 35678979 hsa-mir-138 Epilepsy ZNF883 inhibits NLRP3 ubiquitination and promotes EP through upregulating USP47 by sponging miR +lncRNA target 35678943 hsa-mir-127 Breast Neoplasms CONCLUSION: In summary, our results reported the regulatory mechanism of FOXD3-AS1 in breast cancer progression by targeting miR3p/ARF6 axis to affect cell proliferation, migration, invasion and tumor growth. +genetics_knock down_promote 35678942 hsa-mir-486 Carcinoma, Non-Small-Cell Lung 3p upregulation on NSCLC cell proliferation, invasion and migration were reversed by BRD9 overexpression. +genetics_knock down_suppress 35678923 hsa-mir-424 Diabetic Nephropathies CONCLUSION: Circ_0000064 knockdown ameliorated HG-induced HRMC dysfunctions through miR5p enrichment-mediated WNT2B inhibition, hinting that circ_0000064 contributed to DN development. +transcription factor target 35678909 hsa-mir-1224 Glioblastoma 5p could be a potential target for the prognosis and treatment in GBM. +lncRNA target 35678907 hsa-mir-206 Memory Disorders CONCLUSION: The application of EGb effectively treats SCO-induced memory impairments probably by suppressing miR +lncRNA target 35678907 hsa-mir-1 Memory Disorders CONCLUSION: The application of EGb effectively treats SCO-induced memory impairments probably by suppressing miR +circulation_biomarker_diagnosis_ns 35678691 hsa-mir-155 Lung Neoplasms Using ANX-bead capturing and reverse transcription and quantitative PCR, we detected significantly higher levels of CK19 mRNA, MALAT1 lncRNA, and miR155 miRNA in the plasma of lung cancer patients. +circulation_biomarker_diagnosis_up 35678655 hsa-mir-20a Post-Concussion Syndrome Our research group, through the analysis of miRNomes in platelet concentrates (PCs) stored in blood banks, identified and validated the miR-127 and miR-320a miRNAs as biomarkers of platelet storage lesions (PSLs) in PCs. +circulation_biomarker_diagnosis_up 35678655 hsa-mir-127 Platelet Storage Pool Deficiency Our research group, through the analysis of miRNomes in platelet concentrates (PCs) stored in blood banks, identified and validated the miR-127 and miR-320a miRNAs as biomarkers of platelet storage lesions (PSLs) in PCs. +circulation_biomarker_diagnosis_up 35678655 hsa-mir-20a Platelet Storage Pool Deficiency Our research group, through the analysis of miRNomes in platelet concentrates (PCs) stored in blood banks, identified and validated the miR-127 and miR-320a miRNAs as biomarkers of platelet storage lesions (PSLs) in PCs. +circulation_biomarker_diagnosis_up 35678655 hsa-mir-20a Papillon-Lefevre Disease Our research group, through the analysis of miRNomes in platelet concentrates (PCs) stored in blood banks, identified and validated the miR-127 and miR-320a miRNAs as biomarkers of platelet storage lesions (PSLs) in PCs. +circulation_biomarker_diagnosis_up 35678655 hsa-mir-127 Papillon-Lefevre Disease Our research group, through the analysis of miRNomes in platelet concentrates (PCs) stored in blood banks, identified and validated the miR-127 and miR-320a miRNAs as biomarkers of platelet storage lesions (PSLs) in PCs. In order to validate the miRNAs 127 and 320a methodologically, as PSL biomarkers in a large number of PC bags, we also evaluated important immunological markers involved in the platelet activation/aggregation process-the CD62P receptor (P-selectin), the surface glycoproteins (GP) IIb/IIIa, and the purinergic P2Y12 receptor-via flow cytometry. +circulation_biomarker_diagnosis_up 35678655 hsa-mir-127 Post-Concussion Syndrome Our research group, through the analysis of miRNomes in platelet concentrates (PCs) stored in blood banks, identified and validated the miR-127 and miR-320a miRNAs as biomarkers of platelet storage lesions (PSLs) in PCs. +target gene 35677888 hsa-mir-182 Thyroid Neoplasms CircSND1/miR-182-5p Axis Promotes Proliferative and Invasive Abilities of Thyroid Cancer via Binding Targeting MET. +other 35677715 hsa-mir-465 Infertility Despite abundant expression in the testis, ablation of the miR-465 miRNA cluster using CRISPR-Cas9 did not cause infertility. +other 35677668 hsa-mir-24 Ovarian Neoplasms Chitosan nanoparticle-mediated effect of antimiRNA-324-5p on decreasing the ovarian cancer cell proliferation by regulation of GLI1 expression. +exosome 35677105 hsa-mir-23a Thyroid Cancer, Papillary Inhibitor-miR-23a-3p protected h9c2 cells from ferroptosis accompanying with upregulation of SLC7A11. In conclusion, our results suggest that CF-exos-miR-23a-3p may promote ferroptosis. +exosome 35677105 hsa-mir-23a Atrial Fibrillation Inhibitor-miR-23a-3p protected h9c2 cells from ferroptosis accompanying with upregulation of SLC7A11. In conclusion, our results suggest that CF-exos-miR-23a-3p may promote ferroptosis. +other 35676651 hsa-mir-10a Glioma RESULTS: We found that 3 differentially expressed miRNAs (miR-10a-5p, miR-10b-5p, miR3p), 6 differentially expressed lncRNAs (TTN-AS1, LINC00641, SNHG14, LINC00894, SNHG1, OIP5-AS1), and 49 differentially expressed mRNAs play a vitally critical role in developing GRE. +other 35676651 hsa-mir-10b Glioma RESULTS: We found that 3 differentially expressed miRNAs (miR-10a-5p, miR-10b-5p, miR3p), 6 differentially expressed lncRNAs (TTN-AS1, LINC00641, SNHG14, LINC00894, SNHG1, OIP5-AS1), and 49 differentially expressed mRNAs play a vitally critical role in developing GRE. +other 35676651 hsa-mir-629 Glioma RESULTS: We found that 3 differentially expressed miRNAs (miR-10a-5p, miR-10b-5p, miR3p), 6 differentially expressed lncRNAs (TTN-AS1, LINC00641, SNHG14, LINC00894, SNHG1, OIP5-AS1), and 49 differentially expressed mRNAs play a vitally critical role in developing GRE. +exosome 35676597 hsa-mir-130b Diabetes, Gestational CONCLUSION: Conclusively, GDM-MSCs-derived exosomes shuttling miR-130b-3p repressed proliferation, migration, and angiogenesis of HUVECs by regulating ICAM-1 expression. +other 35676585 hsa-mir-199a Cardiovascular Diseases The two miRNAs with the highest interaction and expression in the development of CVDs were hsa-miR-199a-5p and hsa-miR-199a-3p. +genetics_overexpression_promote 35676548 hsa-mir-630 Carcinoma, Ovarian Epithelial CircCERS6 overexpression hampered the proliferation, migration, invasion, and EMT of EOC cells by up-regulating RASSF8 via sponging miR-630. +lncRNA target 35675666 hsa-mir-1226 Nasopharyngeal Carcinoma Conclusion: These findings indicate that downregulation of GUSBP11 alleviates NPC development by regulating the miR +exosome 35674868 hsa-mir-128 Stomach Neoplasms Conclusively, LINC01091 shuttled by tumor-derived Exos might expedite GC development by activating the ELF4/CDX2 axis via miR +circulation_biomarker_diagnosis_ns 35674773 hsa-mir-21 Hyperlipidemias The plasma levels of let-7a, miR-126, miR-21, and miR-26a were significantly elevated in hyperlipidemic rats at 30 and 50 days after modeling, while the plasma level of miR-29a was significantly decreased. +circulation_biomarker_diagnosis_ns 35674773 hsa-mir-126 Hyperlipidemias The plasma levels of let-7a, miR-126, miR-21, and miR-26a were significantly elevated in hyperlipidemic rats at 30 and 50 days after modeling, while the plasma level of miR-29a was significantly decreased. +other 35674773 hsa-mir-29a Hyperlipidemias miR-29a might serve as a potential early diagnostic biomarker of endothelial injury-related diseases. +circulation_biomarker_diagnosis_ns 35674773 hsa-let-7a Hyperlipidemias The plasma levels of let-7a, miR-126, miR-21, and miR-26a were significantly elevated in hyperlipidemic rats at 30 and 50 days after modeling, while the plasma level of miR-29a was significantly decreased. +other 35674773 hsa-mir-29a Myocardial Infarction, Acute miR-29a might serve as a potential early diagnostic biomarker of endothelial injury-related diseases. +circulation_biomarker_diagnosis_ns 35674773 hsa-mir-26a Myocardial Infarction, Acute The plasma levels of let-7a, miR-126, miR-21, and miR-26a were significantly elevated in hyperlipidemic rats at 30 and 50 days after modeling, while the plasma level of miR-29a was significantly decreased. +circulation_biomarker_diagnosis_ns 35674773 hsa-let-7a Myocardial Infarction, Acute The plasma levels of let-7a, miR-126, miR-21, and miR-26a were significantly elevated in hyperlipidemic rats at 30 and 50 days after modeling, while the plasma level of miR-29a was significantly decreased. +circulation_biomarker_diagnosis_ns 35674773 hsa-mir-26a Hyperlipidemias The plasma levels of let-7a, miR-126, miR-21, and miR-26a were significantly elevated in hyperlipidemic rats at 30 and 50 days after modeling, while the plasma level of miR-29a was significantly decreased. +circulation_biomarker_diagnosis_ns 35674773 hsa-mir-126 Myocardial Infarction, Acute The plasma levels of let-7a, miR-126, miR-21, and miR-26a were significantly elevated in hyperlipidemic rats at 30 and 50 days after modeling, while the plasma level of miR-29a was significantly decreased. +circulation_biomarker_diagnosis_ns 35674773 hsa-mir-21 Myocardial Infarction, Acute The plasma levels of let-7a, miR-126, miR-21, and miR-26a were significantly elevated in hyperlipidemic rats at 30 and 50 days after modeling, while the plasma level of miR-29a was significantly decreased. +genetics_overexpression_promote 35674441 hsa-mir-675 Nasopharyngeal Carcinoma 5p and results in p53 protein overexpression in EBVaGC and NPC cells. +genetics_overexpression_promote 35674441 hsa-mir-675 Epstein-Barr Virus Infections 5p and results in p53 protein overexpression in EBVaGC and NPC cells. +genetics_overexpression_promote 35674441 hsa-mir-675 Corneal dystrophy, epithelial basement membrane 5p and results in p53 protein overexpression in EBVaGC and NPC cells. +other 35674190 hsa-mir-1205 Colorectal Neoplasms Reverse transcriptionquantitative PCR analysis was performed to detect circ_0006174, miR1205 and calciumbinding epidermal growth factor domaincontaining protein 1 (CCBE1) expression levels in CRC tissues and cell lines. Circ_0006174 is an oncogenic circRNA, which participates in the promotion of CRC progression by regulating the miR1205/CCBE1/Wnt pathway. +lncRNA target 35674159 hsa-mir-28 Reperfusion Injury, Renal Ischemia On the whole, the findings of the present study revealed a regulatory pathway modulating miR3283p in IRI, demonstrating that the GATA1mediated regulation of circITGB1 enhanced the H/Rinduced inflammatory response via the miR3283p/PIM1 axis. +genetics_knock down_suppress 35674016 hsa-mir-455 Inflammation SOX2-OT knockdown or miR +lncRNA target 35673973 hsa-mir-144 Hepatorenal Syndrome This study investigated the potential beneficial effects of resveratrol on diclofenac-induced hepatorenal toxicity and explored the role of miR-144 and its relationship to oxidative stress and inflammation triggered by diclofenac. In conclusion, this study demonstrates a potential therapeutic role of resveratrol in mitigating diclofenac-induced hepatorenal insult, possibly via modulating miR-144/Nrf2/GSH axis. +genetics_overexpression_promote 35673915 hsa-mir-744 Carcinoma, Renal Cell 5p overexpression on ccRCC cell proliferation, migration, and invasion (all P < 0.05). +other 35673634 hsa-mir-339 Prostatic Neoplasms 5p and hsa-miR-613 are potential biomarkers for Pca bone metastasis. +other 35673634 hsa-mir-125a Prostatic Neoplasms 5p and hsa-miR-613 are potential biomarkers for Pca bone metastasis. +other 35673634 hsa-mir-30 Prostatic Neoplasms 5p and hsa-miR-613 are potential biomarkers for Pca bone metastasis. +other 35673634 hsa-mir-613 Prostatic Neoplasms 5p and hsa-miR-613 are potential biomarkers for Pca bone metastasis. +circulation_biomarker_diagnosis_ns 35673562 hsa-mir-144 limb ischemia Conclusion: The results expand the scope of blood-borne substances involved in vascular homeostasis and suggest that anti-miR +other 35673452 hsa-mir-126 Diabetes Mellitus The aim of this study was to evaluate the protective effects of interval and continuous aerobic training on diabetic hearts by examining the expression of myocardial miR-126, miR-222 and miR-29a genes. +other 35673452 hsa-mir-222 Diabetes Mellitus The aim of this study was to evaluate the protective effects of interval and continuous aerobic training on diabetic hearts by examining the expression of myocardial miR-126, miR-222 and miR-29a genes. +other 35673452 hsa-mir-29a Diabetes Mellitus The aim of this study was to evaluate the protective effects of interval and continuous aerobic training on diabetic hearts by examining the expression of myocardial miR-126, miR-222 and miR-29a genes. +genetics_knock down_promote 35672774 hsa-mir-18a Ovarian Neoplasms miR-18a-5p knockdown and NACC1 overexpression both annulled the inhibition of hMSC-EVs on OC cell growth. +other 35672444 hsa-mir-19a Colonic Neoplasms Then, sequencing platelet miRNome, we identify miR-19a as the highest expressed miRNA in obese subjects and prove that miR-19a is induced in colon cancer. Last, administration of miR-19a per se in the xenograft colon cancer model is able to promote colon cancer growth. +other 35672444 hsa-mir-19a Obesity, Abdominal Then, sequencing platelet miRNome, we identify miR-19a as the highest expressed miRNA in obese subjects and prove that miR-19a is induced in colon cancer. Last, administration of miR-19a per se in the xenograft colon cancer model is able to promote colon cancer growth. +other 35672285 hsa-mir-181d Fibrosis, Renal In vivo, treatment with miR-181d-containing BMSC-derived EVs was able to restrict the progression of fibrosis in UUO-induced rats. +genetics_GWAS 35672274 hsa-mir-149 Carcinoma, Hepatocellular CONCLUSION: miR-149 rs2292832 polymorphism might be a novel prognostic biomarker for HCC patients with bone metastasis. +genetics_overexpression_promote 35670956 hsa-mir-203a Carcinoma, Non-Small-Cell Lung Overexpression of miR-203a-3p inhibits NSCLC cell proliferation, migration and invasion, and promotes cellular apoptosis in vitro. +genetics_knock down_promote 35670955 hsa-mir-433 Amyloidosis In conclusion, circ-HUWE1 knockdown alleviates Amyloid-beta-induced neuronal injury in SK-N-SH cells via miR +genetics_knock down_promote 35670955 hsa-mir-433 Plaque, Amyloid In conclusion, circ-HUWE1 knockdown alleviates Amyloid-beta-induced neuronal injury in SK-N-SH cells via miR +lncRNA target 35670535 hsa-mir-9a Inflammatory Bowel Diseases This study found that miRNA-9a-5p could inhibit the TLR4 signaling activation by targeting FOXO1, thereby exerting a protective effect on the mucosal barrier injury in IBD. +genetics_overexpression_promote 35670491 hsa-mir-28 Cholangiocarcinoma 5p-overexpression CCA cells and their control cells, which further confirmed that CD44 was required in miR +circulation_biomarker_diagnosis_ns 35670145 hsa-mir-1 Myocardial Infarction Using a highly sensitive miRNA biosensor that the authors developed, the exact same increase in miR-1, miR-208b, and miR-499 levels in the MI-on-chip and the time-matched human blood plasma samples collected before and after ischemia and reperfusion, is shown. +circulation_biomarker_diagnosis_ns 35670145 hsa-mir-208b Myocardial Infarction Using a highly sensitive miRNA biosensor that the authors developed, the exact same increase in miR-1, miR-208b, and miR-499 levels in the MI-on-chip and the time-matched human blood plasma samples collected before and after ischemia and reperfusion, is shown. +circulation_biomarker_diagnosis_ns 35670145 hsa-mir-499 Myocardial Infarction Using a highly sensitive miRNA biosensor that the authors developed, the exact same increase in miR-1, miR-208b, and miR-499 levels in the MI-on-chip and the time-matched human blood plasma samples collected before and after ischemia and reperfusion, is shown. +lncRNA target 35669642 hsa-mir-223 Stomach Neoplasms Our results showed that Celecoxib could reverse invasion and metastasis of gastric cancer through Lnc_AC006548.28-miRLAMC2 pathway. +other 35669607 hsa-mir-155 Chronic Periodontitis RESULTS: The level of miR-155 was significantly higher in patients with chronic periodontitis (P < 0.001). CONCLUSION: As the expression level of miR-155, TNF-alpha, and IL-6 genes was higher in subjects with chronic periodontitis than healthy individuals, it might suggest a role for miR-155 in patients with chronic periodontitis. +exosome 35669425 hsa-mir-411 Colonic Diseases Upon entering OL cells, exosomal miR +genetics_overexpression_promote 35669376 hsa-mir-339 Colonic Neoplasms COL11A1 upregulation promoted colon carcinoma cell functions, while overexpressing miR +target gene 35669244 hsa-mir-205 Stomach Neoplasms MiR-205-5p Functions as a Tumor Suppressor in Gastric Cancer Cells through Downregulating FAM84B. +genetics_knock down_promote 35669195 hsa-mir-363 Moyamoya Disease Results: The microarray results showed 12 differentially expressed miRNAs in leukocytes of MMD patients compared with controls (fold change >2.0, p < 0.05 and FDR <0.05), of which 8 miRNAs were upregulated (miRNA +genetics_knock down_promote 35669195 hsa-mir-340 Moyamoya Disease Results: The microarray results showed 12 differentially expressed miRNAs in leukocytes of MMD patients compared with controls (fold change >2.0, p < 0.05 and FDR <0.05), of which 8 miRNAs were upregulated (miRNA +genetics_knock down_promote 35669195 hsa-mir-29b Moyamoya Disease Results: The microarray results showed 12 differentially expressed miRNAs in leukocytes of MMD patients compared with controls (fold change >2.0, p < 0.05 and FDR <0.05), of which 8 miRNAs were upregulated (miRNA +genetics_knock down_promote 35669195 hsa-mir-6807 Moyamoya Disease Results: The microarray results showed 12 differentially expressed miRNAs in leukocytes of MMD patients compared with controls (fold change >2.0, p < 0.05 and FDR <0.05), of which 8 miRNAs were upregulated (miRNA +genetics_knock down_promote 35669195 hsa-mir-142 Moyamoya Disease Results: The microarray results showed 12 differentially expressed miRNAs in leukocytes of MMD patients compared with controls (fold change >2.0, p < 0.05 and FDR <0.05), of which 8 miRNAs were upregulated (miRNA +genetics_knock down_promote 35669195 hsa-mir-451a Moyamoya Disease Results: The microarray results showed 12 differentially expressed miRNAs in leukocytes of MMD patients compared with controls (fold change >2.0, p < 0.05 and FDR <0.05), of which 8 miRNAs were upregulated (miRNA +genetics_knock down_promote 35669195 hsa-mir-144 Moyamoya Disease Results: The microarray results showed 12 differentially expressed miRNAs in leukocytes of MMD patients compared with controls (fold change >2.0, p < 0.05 and FDR <0.05), of which 8 miRNAs were upregulated (miRNA +genetics_knock down_promote 35669195 hsa-mir-486 Moyamoya Disease Results: The microarray results showed 12 differentially expressed miRNAs in leukocytes of MMD patients compared with controls (fold change >2.0, p < 0.05 and FDR <0.05), of which 8 miRNAs were upregulated (miRNA +genetics_knock down_promote 35669102 hsa-mir-28 gastric adenocarcinoma 3p overexpression. +lncRNA target 35669101 hsa-mir-138 Carcinoma, Hepatocellular 5p may serve as a useful therapeutic target for miRNA-based HCC therapy. +other 35668995 hsa-mir-130b Polycystic Ovary Syndrome Forced expression of ZNF217 in PCOS theca cells reduced androgen production, CYP17A1 and DENND1A.V2 mRNA, while increasing mIR-130b-3p. These observations suggest that ZNF217 is part of a network of PCOS candidate genes regulating thecal cell androgen production involving DENND1A.V2 and miR-130b-3p. +other 35668916 hsa-mir-455 Carotid Stenosis 5p is an independent risk factor for the degree of CAS, and has a certain predictive value for the development of CIEs. +exosome 35668915 hsa-mir-142 Rhinitis, Allergic CONCLUSION: Tfh-derived exosomes induce DC maturation by regulating miR5p/CDK5/STAT3 signaling pathway, thereby promoting the occurrence of AR. +other 35668777 hsa-mir-590 Myocardial Reperfusion Injury 5p and the heart development transcription factor KBTBD7. +lncRNA target 35668775 hsa-mir-410 Arthritis, Rheumatoid Our data suggest that TSC can inhibit the excessive proliferation of FLS to treat RA, the mechanism of which may be closely related to regulation of the lncRNA OIP5-AS1/miR +circRNA target 35668527 hsa-mir-494 Small Cell Lung Carcinoma CONCLUSIONS: CircVAPA promotes SCLC progression via the miR +circRNA target 35668527 hsa-mir-377 Small Cell Lung Carcinoma CONCLUSIONS: CircVAPA promotes SCLC progression via the miR +other 35668388 hsa-mir-19b Metabolic Diseases Seminal miR19b levels were also negatively correlated with metabolic syndrome. +other 35668388 hsa-mir-19a Metabolic Diseases Seminal miR19b levels were also negatively correlated with metabolic syndrome. +other 35668364 hsa-mir-218-1 Abortion, Spontaneous CONCLUSIONS: TCS regulated miR1-3p/SLC35C1 axis to modulate the proliferation, migration, invasion and inflammatory response of trophoblast cells in vitro, which might provide novel insights for spontaneous abortion prevention. +other 35668364 hsa-mir-218 Abortion, Spontaneous CONCLUSIONS: TCS regulated miR1-3p/SLC35C1 axis to modulate the proliferation, migration, invasion and inflammatory response of trophoblast cells in vitro, which might provide novel insights for spontaneous abortion prevention. +other 35668332 hsa-mir-137 Breast Neoplasms While miR-124a levels increased (p = 0.021) in the tumor tissue, the expression of miR-137 was downregulated (p = 0.041) after NACT in HR positive BC. Although miRs levels did not impact the response to NACT, we found miR-124a and miR-137 levels to be related to hormonal sensitivity of BC. +other 35668131 hsa-mir-221 Pulmonary Arterial Hypertension 5p) whose expression was validated by qRT-PCR, have been reported for cardiogenesis, cardiomyocyte proliferation, cardioprotection and cardiac dysfunction. +other 35668131 hsa-mir-218 Pulmonary Arterial Hypertension 5p) whose expression was validated by qRT-PCR, have been reported for cardiogenesis, cardiomyocyte proliferation, cardioprotection and cardiac dysfunction. +other 35668131 hsa-mir-873 Pulmonary Arterial Hypertension 5p) whose expression was validated by qRT-PCR, have been reported for cardiogenesis, cardiomyocyte proliferation, cardioprotection and cardiac dysfunction. +transcription factor target 35667855 hsa-mir-199a Lung Injury In summary, the BMSC-exo could participate in the regulation of ENaC through miR-199a-3p originated from BMSC-exo, thereby providing a new pharmacological tool for the treatment of ALI. +lncRNA target 35667653 hsa-mir-20b Breast Neoplasms Conclusion: Overall, this study highlights the important role of LINC00680 in docetaxel resistance through the miR-320b/CDKL5 pathway and provides a novel therapeutic strategy for BC drug resistance. +genetics_overexpression_promote 35667541 hsa-mir-424 Acute Lung Injury Overexpression of miR +other 35667514 hsa-mir-432 Carcinoma, Non-Small-Cell Lung Mechanistically, circASCC3 sponged miR5p to increase complement C5a levels, which enhanced the progression and dysfunctional immune status of NSCLC. +other 35667342 hsa-mir-410 Abortion, Habitual 5p and lower ITGA6 expression. +transcription factor target 35667086 hsa-mir-132 Colorectal Neoplasms 3p inhibits the proliferation, migration and invasion of CRC cells. +lncRNA target 35666685 hsa-mir-140 Leukemia, Myeloid, Acute CONCLUSION: MiR-140 may target FAM230B to suppress cell proliferation in AML. +transcription factor target 35666636 hsa-mir-548d Stomach Neoplasms Dual-fluorescence and quantitative PCR assays clarified that miR-548d-3p may be one of the target miRNAs of GKN1, which was up-regulated in GC tissues. CONCLUSIONS: In summary, we clarified that miR-548d-3p regulates GKN1 to participate in GC cell migration and invasion, and provides a possible target for the prognostic diagnosis and treatment of GC. +circulation_biomarker_diagnosis_up 35666610 hsa-mir-22 Carcinoma, Hepatocellular METHODS: Real-time reverse transcription polymerase chain reaction (RT-PCR) was carried out to detect serum miR-16, miR-22, and miR-122 expression in 100 HCC patients and 100 controls (including hepatitis B, liver cirrhosis, liver metastases, hepatic hemangioma, health group, and each of them had 20 subjects). +circulation_biomarker_diagnosis_up 35666610 hsa-mir-122 Carcinoma, Hepatocellular CONCLUSION: Our findings illustrate that both circulating miR-16 and miR-122 can provide value for early diagnosis of HCC and they are potential biomarkers for the early-stage HCC. +circulation_biomarker_diagnosis_up 35666610 hsa-mir-16 Carcinoma, Hepatocellular CONCLUSION: Our findings illustrate that both circulating miR-16 and miR-122 can provide value for early diagnosis of HCC and they are potential biomarkers for the early-stage HCC. +epigenetics 35666529 hsa-mir-124-2 Cervical Intraepithelial Neoplasia A negative FAM19A4/miR124-2 methylation test can rule out progressive CIN disease in pregnant women diagnosed with CIN3. +transcription factor target 35666424 hsa-mir-424 Breast Neoplasms 3p is more effective in inhibiting MCF-7 breast cancer development than monotherapies with miR +transcription factor target 35666424 hsa-mir-142 Breast Neoplasms 3p is more effective in inhibiting MCF-7 breast cancer development than monotherapies with miR +genetics_knock down_promote 35666423 hsa-mir-517b Carcinoma, Hepatocellular Meanwhile, miR-517b-3p has overexpression in PVTT samples, and serves as a candidate diagnostic and prognostic biomarker in HCC patients with PVTT. +exosome 35666058 hsa-mir-92b Ventricular Premature Complexes Real-Time quantitative PCR (RT-qPCR) experiments showed that miR-92b-3p, which is important for alleviating VC, was expressed highly in both VSMCs and exosomes after CUR intervention. In addition, in the rat calcification models, CUR attenuated vitamin D3-induced VC by increasing miR-92b-3p expression and decreasing KLF4 expression in the aorta. +circulation_biomarker_diagnosis_up 35664973 hsa-mir-27b Alopecia Areata Also, we observed that, miR-101 and miR-27b are upregulated, while miR-103 and miR3p are downregulated in peripheral blood mononuclear cells of AA patients compared to controls. +circulation_biomarker_diagnosis_up 35664973 hsa-mir-101 Alopecia Areata Also, we observed that, miR-101 and miR-27b are upregulated, while miR-103 and miR3p are downregulated in peripheral blood mononuclear cells of AA patients compared to controls. +circulation_biomarker_diagnosis_up 35664973 hsa-mir-2355 Alopecia Areata Also, we observed that, miR-101 and miR-27b are upregulated, while miR-103 and miR3p are downregulated in peripheral blood mononuclear cells of AA patients compared to controls. +circulation_biomarker_diagnosis_up 35664973 hsa-mir-103 Alopecia Areata Also, we observed that, miR-101 and miR-27b are upregulated, while miR-103 and miR3p are downregulated in peripheral blood mononuclear cells of AA patients compared to controls. +epigenetics 35664920 hsa-mir-155 Pre-Eclampsia This study is aimed at exploring the role of miR-155 in the inflammatory pathogenesis of PE. Results showed that miR-155 was remarkably upregulated and inversely correlated with the promoter methylation level in the placental tissue from PE patients. +lncRNA target 35664787 hsa-mir-30 Urinary Bladder Neoplasms 5p inhibitor. +other 35664767 hsa-mir-181a Lung Neoplasms More importantly, we established the AL035458.2/hsa-miR-181a-5p axis as the most likely upstream ncRNA-related pathway of NCAPG2 in LUAD. +other 35664767 hsa-mir-181a Adenocarcinoma of Lung More importantly, we established the AL035458.2/hsa-miR-181a-5p axis as the most likely upstream ncRNA-related pathway of NCAPG2 in LUAD. +other 35664431 hsa-mir-29b Neurogenic Inflammation CONCLUSION: CGA upregulates MIR497HG to curb miR-29b-3p expression, hence initiating the SIRT1/NF-kappaB signaling pathway and repressing OGD-elicited inflammation, oxidative stress, and neuron apoptosis. +other 35664431 hsa-mir-497 Neurogenic Inflammation CONCLUSION: CGA upregulates MIR497HG to curb miR-29b-3p expression, hence initiating the SIRT1/NF-kappaB signaling pathway and repressing OGD-elicited inflammation, oxidative stress, and neuron apoptosis. +other 35663991 hsa-mir-146a psoriasis 1 In addition, estrogen was found to affect the expression of certain genes (vgll3 and cebpb), microRNAs (miR146a and miR21), and immune cells (DCs and gammadelta T cells) as well as chemokines (CCL5 and CXCL10) and cytokines (TNF-alpha, IL-6, IL-22, IL-23, and IL-17 family), which promoted the skin inflammation. +other 35663991 hsa-mir-21 psoriasis 1 In addition, estrogen was found to affect the expression of certain genes (vgll3 and cebpb), microRNAs (miR146a and miR21), and immune cells (DCs and gammadelta T cells) as well as chemokines (CCL5 and CXCL10) and cytokines (TNF-alpha, IL-6, IL-22, IL-23, and IL-17 family), which promoted the skin inflammation. +lncRNA target 35663842 hsa-mir-423 Stomach Neoplasms CONCLUSION: CircPVT1 modulated cell growth, invasion and migration through EMT mediation in gastric cancer through miR5p/Smad3 pathway. +genetics_overexpression_suppress 35663593 hsa-mir-132 Retinoblastoma 3p inhibition or PAX6 overexpression reversed circRNF20 deficiency-mediated effects on RB cell malignant behaviors. +other 35663558 hsa-mir-10b Amyotrophic Lateral Sclerosis The most significant change occurred in miR-10b, which was significantly increased in ALS, but not CTE or CTE ALS. +other 35663558 hsa-mir-10b Brain Injury, Chronic The most significant change occurred in miR-10b, which was significantly increased in ALS, but not CTE or CTE ALS. +other 35663309 hsa-mir-1224 Myocardial Ischemia 3p, and miR-548b-3p) were significantly upregulated in T2DM IHD patients compared to T2DM patients without IHD. +other 35663309 hsa-mir-147 Diabetes Mellitus, Type 2 3p, and miR-548b-3p) were significantly upregulated in T2DM IHD patients compared to T2DM patients without IHD. +other 35663309 hsa-mir-615 Myocardial Ischemia 3p, and miR-548b-3p) were significantly upregulated in T2DM IHD patients compared to T2DM patients without IHD. +other 35663309 hsa-mir-147 Myocardial Ischemia 3p, and miR-548b-3p) were significantly upregulated in T2DM IHD patients compared to T2DM patients without IHD. +other 35663309 hsa-mir-615 Diabetes Mellitus, Type 2 3p, and miR-548b-3p) were significantly upregulated in T2DM IHD patients compared to T2DM patients without IHD. +other 35663309 hsa-mir-5196 Diabetes Mellitus, Type 2 3p, and miR-548b-3p) were significantly upregulated in T2DM IHD patients compared to T2DM patients without IHD. +other 35663309 hsa-mir-1224 Diabetes Mellitus, Type 2 3p, and miR-548b-3p) were significantly upregulated in T2DM IHD patients compared to T2DM patients without IHD. +other 35663309 hsa-mir-5196 Myocardial Ischemia 3p, and miR-548b-3p) were significantly upregulated in T2DM IHD patients compared to T2DM patients without IHD. +other 35663309 hsa-mir-548b Myocardial Ischemia 3p, and miR-548b-3p) were significantly upregulated in T2DM IHD patients compared to T2DM patients without IHD. +other 35663309 hsa-mir-548b Diabetes Mellitus, Type 2 3p, and miR-548b-3p) were significantly upregulated in T2DM IHD patients compared to T2DM patients without IHD. +lncRNA target 35663229 hsa-mir-15a Neuroblastoma These findings demonstrate that miR-15a and miR-15b induce an anti-tumor immune response by targeting PD-L1 in NB. +lncRNA target 35663229 hsa-mir-15b Neuroblastoma These findings demonstrate that miR-15a and miR-15b induce an anti-tumor immune response by targeting PD-L1 in NB. +other 35663198 hsa-mir-432 Carcinoma, Hepatocellular In this study, using bioinformatic analysis as well as cellular and animal models, we screened the differentially expressed (DE) miRNA-432 and SLC38A1 gene in ASH. +other 35663198 hsa-mir-432 Fatty Liver, Alcoholic In this study, using bioinformatic analysis as well as cellular and animal models, we screened the differentially expressed (DE) miRNA-432 and SLC38A1 gene in ASH. +lncRNA target 35663194 hsa-mir-664a Cardiovascular Diseases And lncRNA Punisher and miR-664a-5p could serve as the novel and potential targets in the diagnosis and treatment of cardiovascular diseases. +genetics_GWAS 35662862 hsa-mir-21 Breast Neoplasms Epigenetic modifications have been observed as a decline in miRNA-21 expression and breast cancer stem cell (CSC) population after 3 cycles of standard chemotherapy. The miRNA-21 expression in breast cancer tissue was quantified by quantitative PCR (real-time PCR) using the standard protocol. +circRNA target 35662705 hsa-mir-132 Colorectal Neoplasms Furthermore, we found quercetin can notably suppress the progression of CRC via mediation of the hsa_circ_0006990/miR3p/MUC13 axis. +genetics_overexpression_promote 35662671 hsa-mir-542 Tuberculosis Overexpression of VPS11 or depletion of miR +transcription factor target 35662508 hsa-mir-143 Schizophrenia Notably, miR143-3p is a critical NRG-1 target related to mitochondrial dysfunction, and miR143-3p levels in neural stem cells associate with severity to olanzapine resistance in TRS. CONCLUSIONS: Our findings provide direct evidence of olanzapine resistance resulting from NRG-1 deficiency-induced mitochondrial dysfunction, and they link olanzapine resistance and NRG-1 deficiency-induced mitochondrial dysfunction to an NRG-1/miR143-3p axis, which constitutes a novel biomarker and target for TRS. +transcription factor target 35662287 hsa-mir-200c Non-alcoholic Fatty Liver Disease Collectively, our results suggest that HAS2 is negatively regulated by miR-200c and contributes to the development of acute liver injury and chronic liver inflammation via hyaluronan-mediated immune signaling. +genetics_overexpression_promote 35662219 hsa-mir-181b Brain Injuries, Traumatic We found that miR181b overexpression effectively reduced apoptosis and neuroinflamatory response after traumatic brain injury and promoted the transformation of microglia to the anti-inflammatory phenotype. +circRNA target 35662113 hsa-mir-665 Angelman Syndrome CONCLUSIONS: Circ_ARHGAP32 might be a potential target for AS treatment, which promoted ox-LDL-induced VSMCs proliferation and migration by regulating miR-665/FGF2 network. +other 35662106 hsa-mir-204 Breast Neoplasms CONCLUSIONS: Our findings suggested that CREB5 could be a potential biomarker of disease progression in basal subtype of breast cancer, and that perturbations of the miR-204/CREB5 axis plays an important role in VM development in breast cancer cells. +lncRNA target 35662010 hsa-mir-19a pancreatic adenocarcinoma MiR-19a-3p was a downstream target of LINC01857, and miR-19a-3p levels were significantly decreased in PDAC cells. CONCLUSION: LINC01857 promotes malignant phenotypes of PDAC cells via upregulation of SMOC2 by interacting with miR-19a-3p. +circRNA target 35661832 hsa-mir-655 Stomach Neoplasms Collectively, circXRCC5 facilitates GC progression through the HNRNPC/circXRCC5/miR +other 35661648 hsa-mir-148b Glomerulonephritis, IGA METHODS: We measured renal megalin mRNA and miR-148b, previously identified as a regulator of megalin, in a retrospective cohort of 417 IgAN patients at the time of biopsy, and evaluated their associations with chronic kidney disease (CKD) progression event, defined as end-stage renal disease or >/=40% decline in estimated glomerular filtration rate, using Cox proportional hazard models. +other 35661648 hsa-mir-148b Renal Insufficiency, Chronic METHODS: We measured renal megalin mRNA and miR-148b, previously identified as a regulator of megalin, in a retrospective cohort of 417 IgAN patients at the time of biopsy, and evaluated their associations with chronic kidney disease (CKD) progression event, defined as end-stage renal disease or >/=40% decline in estimated glomerular filtration rate, using Cox proportional hazard models. +lncRNA target 35661494 hsa-mir-451 Inferior Wall Myocardial Infarction The results showed that IMI exposure induced autophagy accompanied by advanced autophagy markers BNIP3, Beclin1 and LC3/ in CIK cells, reduced the levels of miR-451, increased the expression of Cab39 and AMPK, inhibited AKT/mTOR signaling, and activated the JNK pathway. These results indicate that eucalyptol could alleviate IMI-induced autophagy through the miR-451/Cab39/AMPK axis in fish kidney cells. +other 35661455 hsa-let-7b COVID-19 At the same time, MIRLET7BHG and MALAT1 are upregulated in excitatory neurons of FC and neurons of CP, respectively. Here, it is hypothesized that downregulation of NORAD, NEAT1, and STXBP5-AS1, and upregulation of MIRLET7BHG and MALAT1 might deregulate respectively 51, 6, and 37, and 31 and 19 mRNAs in cell types of FC and CP. +circRNA target 35661247 hsa-mir-135b Adenocarcinoma of Lung To summarize, we demonstrated that melatonin decreases the expression of circ_0017109 and suppresses the non-small-cell lung cancer cell migration, invasion, and proliferation through decreasing TOX3 expression via direct activation of miR-135b-3p. +lncRNA target 35660716 hsa-mir-1 Adenocarcinoma of Lung 3p/E2F8 constrained LUAD malignant progression through NF-kappaB pathway, which may provide possible targets for LUAD diagnosis and treatment. +exosome 35660458 hsa-mir-21 Breast Neoplasms 5p and miRNA-10b-5p, both of which are involved in EMT, in breast cancer-derived exosomes of various grades in order to identify new biomarkers involved in breast cancer progression. +exosome 35660458 hsa-mir-10b Breast Neoplasms 5p and miRNA-10b-5p, both of which are involved in EMT, in breast cancer-derived exosomes of various grades in order to identify new biomarkers involved in breast cancer progression. +circulation_biomarker_diagnosis_up 35659970 hsa-mir-483 Carcinoma, Hepatocellular 5p or plasma hsa-miR +lncRNA target 35659969 hsa-mir-134 Depression 5p exerts an enormous effect on dendritic deficits by promoting AMPK-mediated mitophagy and provides a potential new target for antidepressant drug research and development. +circulation_biomarker_diagnosis_up 35659599 hsa-mir-27a Alzheimer Disease CONCLUSIONS: The expression trends of NEAT1 and miR-27a-3p in the serum and cerebrospinal fluid of AD patients are consistent, the level of NEAT1 is increased, and the level of miR-27a-3p is decreased. +other 35659483 hsa-mir-34a Upper Tract Urothelial Carcinoma Other non-coding RNAs, i.e.,: miR-34a, DLGAP1-AS1, USP39, and RNA5SP479, were highlighted by network analyses to have potential in the pathogenesis of UTUC. +other 35659238 hsa-mir-450a-2 Depressive Disorder, Major 3p and emotional abuse could effectively diagnose MDD in adolescents with 82.4% sensitivity and 81.6% specificity. +lncRNA target 35659199 hsa-mir-199b Pancreatic Carcinoma It was also discovered that myelin regulatory factor (MYRF) was targeted by miR-199b-5p and positively correlated with LINC01133 expression in PC, and LINC01133 modulated PC progression through miR-199b-5p/MYRF pathway. In conclusion, we demonstrated that YY1-mediated the upregulation of LINC0113 increased MYRF expression by sponging miR-199b-5p, resulting in the accelerated development of PC. +genetics_knock down_promote 35659193 hsa-mir-129 Periodontitis Knockdown lncZFY's improvement effect on periodontitis was reversed by depressive miR +lncRNA target 35659191 hsa-mir-125a Venous Thrombosis All in all, suppression of LINC01123 restrains LEDVT via miR-125a-3p to target IL1R1. +lncRNA target 35658886 hsa-mir-296 Breast Neoplasms CONCLUSION: Our results indicate that lncRNA ORLNC1 acts as a tumor suppressor by regulating the miR-296/PTEN axis in HER2+ breast cancer. +transcription factor target 35658330 hsa-mir-181b Precursor Cell Lymphoblastic Leukemia-Lymphoma The miRNA-181b-5p/SSX2IP axis may be a promising target for intervention against the malignant behaviors of ALL. +lncRNA target 35658236 hsa-mir-1298 Myocardial Reperfusion Injury CONCLUSION: TNA has demonstrated a potential ability to alleviate the cardiac injury and attenuate the inflammatory response following ischemia-reperfusion in the rat model through modulation of the expression of RNA panel (VAV3 mRNA/miR-1298/lncRNA JRKL-AS1) and TNF- alpha protein. +lncRNA target 35658112 hsa-mir-210 Adenocarcinoma of Lung 3p could be a promising target for immunomodulatory therapeutic strategies against lung adenocarcinoma. +other 35657974 hsa-mir-222 Colonic Neoplasms These findings identify a novel mechanism whereby post-M3R PKC/p38 MAPK signaling stimulates miR-222 expression and colon cancer cell proliferation. +circulation_biomarker_diagnosis_ns 35657638 hsa-mir-19a Breast Neoplasms Compared with normal subjects, miR-19a-3p was highly expressed in plasma of patients with breast cancer. +exosome 35657460 hsa-mir-16 Spinal Cord Injuries CONCLUSIONS: Exosomal circZFHX3 inhibited LPS-induced BV-2 cell injury partly by regulating the miR +circulation_biomarker_diagnosis_ns 35657082 hsa-mir-375 Insulin Resistance RESULTS: Circulating miR3p was related to fasting insulin and insulin resistance in participants with prediabetes. +circulation_biomarker_diagnosis_ns 35657082 hsa-mir-375 Prediabetic State RESULTS: Circulating miR3p was related to fasting insulin and insulin resistance in participants with prediabetes. +lncRNA target 35656441 hsa-mir-452 Precursor Cell Lymphoblastic Leukemia-Lymphoma CONCLUSION: MAGI2-AS3 inhibits ALL development via modulating miR +circRNA target 35656024 hsa-mir-668 Colorectal Neoplasms 3p/ID4 axis in CRC progression and provided potential therapeutic targets and clinical prognostic markers for CRC. +circulation_biomarker_diagnosis_ns 35655924 hsa-mir-196a Abortion, Habitual RESULTS: We first demonstrated that miR-196a-5p expression was higher in the cytotrophoblasts of villous tissues and plasma EVs from RM patients. +exosome 35655918 hsa-mir-887 Breast Neoplasms 3p in MDA-MB-231 cells, BC cells were treated with EV-inhi to observe drug resistance. +other 35655761 hsa-mir-4728 Breast Neoplasms We showed here that mir-4728 was the most significantly upregulated pre-miRNA in HER2-positive breast cancer patients (fold-change: 4.37), and it could serve as a strong diagnostic factor for the HER2 status in breast cancer patients (p < 0.0001). +circulation_biomarker_diagnosis_ns 35655754 hsa-mir-153 Parkinson Disease The plasma miR-153 level in de novo PD was lower than that in treated patients (p = 0.006), its level increased gradually with disease duration (r = 0.358, p = 0.002) and Unified Parkinson's Disease Rating Scale Part III score (r = 0.264, p = 0.022). +circulation_biomarker_diagnosis_ns 35655754 hsa-mir-223 Parkinson Disease RESULTS: The expression levels of plasma miR-153 and miR-223 were significantly decreased in patients with PD relative to NCs. +other 35655727 hsa-mir-141 Urinary Bladder Neoplasms In addition, the above two indicators are closely related to and related to the tumor grade of bladder cancer patients, and the high expression of miR-141 and CD147 brings the poor prognosis effect to bladder cancer patients. +genetics_knock down_suppress 35655441 hsa-mir-590 Esophageal Squamous Cell Carcinoma Importantly, it was confirmed that LRP6 was miR-590's downstream target and LRP6 over-expression also partly abolished the role of miR-590 overexpression in ESCC cells. +genetics_overexpression_promote 35655310 hsa-mir-183 Breast Neoplasms Phenotypic effects of miR-183 overexpression in triple-negative breast cancer (TNBC) cell lines were investigated in vitro and in vivo by quantifying migration, proliferation, tumor growth and metastasis. +genetics_overexpression_promote 35655310 hsa-mir-183 Triple Negative Breast Neoplasms Phenotypic effects of miR-183 overexpression in triple-negative breast cancer (TNBC) cell lines were investigated in vitro and in vivo by quantifying migration, proliferation, tumor growth and metastasis. However, TNBC cell lines displayed reduced proliferation and invasion upon overexpression of pre-miR-183. +circRNA target 35655258 hsa-mir-1248 Prostatic Neoplasms CONCLUSIONS: These results demonstrated that circ_0004585 played an oncogenic role during PCa invasion and metastasis by targeting the miR-1248/TM9SF4 axis while providing new insight into therapeutic strategy development for metastatic PCa. +circulation_biomarker_diagnosis_up 35655254 hsa-mir-382 Carcinoma, Hepatocellular Upregulation of PTEN expression by plasmid transfection can reverse the invasive effect of miR +lncRNA target 35654787 hsa-mir-140 Prostatic Neoplasms Collectively, our findings demonstrate that circSCAF8 contributes to PCa progression through the circSCAF8-miR +lncRNA target 35654787 hsa-mir-335 Prostatic Neoplasms Collectively, our findings demonstrate that circSCAF8 contributes to PCa progression through the circSCAF8-miR +other 35654454 hsa-mir-183 Lung Neoplasms We have previously reported that in different cancer types, including nonsmall cell lung cancer (NSCLC), the microRNA-183/96/182 cluster (m96cl) is highly repressed in cells that have undergone EMT. +other 35654124 hsa-mir-211 Parkinson Disease Conclusively, these results emphasize the neurotherapeutic impact of empagliflozin in PD by moderating the GRP78/PERK/eIF2alpha/CHOP ER stress pathway, downregulating miR5p, resolving oxidative stress, lessening astrocyte/microglial activation and neuroinflammation, along with augmenting autophagy. +lncRNA target 35653827 hsa-mir-612 Breast Neoplasms Besides, FKBP4 could activate the cell proliferation and inhibit cell apoptosis and autophagy, which could relieve the inhibitory effect of miR-3612 on breast cancer cells. +genetics_knock down_suppress 35653494 hsa-mir-185 Alveolar Bone Loss CONCLUSION: As a target gene of miR5p, MZB1 plays a crucial role in inhibiting the migration of hPDLCs through NF-kappaB signaling pathway and deteriorating alveolar bone loss. +circulation_biomarker_diagnosis_ns 35653294 hsa-mir-1260b Pediatric Obesity We detected five cord serum miRNAs differentially expressed in children at high risk of obesity compared with the levels in children at low risk, namely, miR +circulation_biomarker_diagnosis_ns 35653294 hsa-mir-194 Pediatric Obesity We detected five cord serum miRNAs differentially expressed in children at high risk of obesity compared with the levels in children at low risk, namely, miR +circulation_biomarker_diagnosis_ns 35653294 hsa-mir-130a Pediatric Obesity We detected five cord serum miRNAs differentially expressed in children at high risk of obesity compared with the levels in children at low risk, namely, miR +circulation_biomarker_diagnosis_ns 35653294 hsa-mir-516 Pediatric Obesity We detected five cord serum miRNAs differentially expressed in children at high risk of obesity compared with the levels in children at low risk, namely, miR +circulation_biomarker_diagnosis_ns 35653294 hsa-mir-4709 Pediatric Obesity We detected five cord serum miRNAs differentially expressed in children at high risk of obesity compared with the levels in children at low risk, namely, miR +other 35652400 hsa-mir-128 Prostatic Neoplasms The study's question is: can miR-128/193a- 5p/494 be related to imatinib resistance in PCa? METHODS: LNCaP and PC3 cells were treated with imatinib in IC50 doses. +circulation_biomarker_diagnosis_ns 35652182 hsa-mir-582 Glioblastoma CONCLUSION: High serum levels of miRNA +circulation_biomarker_diagnosis_ns 35652182 hsa-mir-363 Glioblastoma CONCLUSION: High serum levels of miRNA +genetics_overexpression_promote 35652063 hsa-mir-613 Colorectal Neoplasms RESULTS: CircEA-2a was overexpressed in CRC, while miR +target gene 35652045 hsa-mir-191 Colonic Neoplasms Hypoxia-Induced Upregulation of lncRNA ELFN1-AS1 Promotes Colon Cancer Growth and Metastasis Through Targeting TRIM14 via Sponging miR-191-5p. +genetics_GWAS 35651980 hsa-mir-222 Thyroid Cancer, Papillary 3p in PTC tissues harboring BRAF(V600E) mutation compared with BRAF wild type (BRAF(WT) ) from collected PTC clinical samples. +genetics_knock down_promote 35651928 hsa-mir-153 Ovarian Neoplasms 3p attenuated the inhibitory influence of knockdown FOXR2 on cisplatin resistance of OC cells. +other 35651814 hsa-mir-483 Carcinoma, Hepatocellular miR-483 presented the best diagnostic potential because it showed the highest diagnostic accuracy for distinguishing HCV-related HCC patients from controls (AUC = 0.98) with 100% sensitivity. +circulation_biomarker_diagnosis_up 35651814 hsa-mir-335 Carcinoma, Hepatocellular In conclusion, studied microRNAs (miR-122, miR-483, and miR-335) could serve as potential non-invasive early diagnostic biomarkers for HCC, and we identified a panel of three serum microRNAs with high accuracy in HCC diagnosis. +circulation_biomarker_diagnosis_up 35651814 hsa-mir-122 Carcinoma, Hepatocellular In conclusion, studied microRNAs (miR-122, miR-483, and miR-335) could serve as potential non-invasive early diagnostic biomarkers for HCC, and we identified a panel of three serum microRNAs with high accuracy in HCC diagnosis. +exosome 35651811 hsa-mir-199a Osteosarcoma Exosomal MiR-199a-5p Inhibits Tumorigenesis and Angiogenesis by Targeting VEGFA in Osteosarcoma. +other 35651789 hsa-mir-532 Adenocarcinoma of Lung Finally, we constructed a ceRNA network that includes hsa-miR5p and four mRNAs (GALNT3, CYCS, EIF5A, and ITGB4) specific to AL139385.1 in LUAD. +circulation_biomarker_diagnosis_up 35651785 hsa-mir-620 Esophageal Neoplasms Through the Gene Expression Omnibus (GEO) database, miR-620 was selected as a serum miRNA highly expressed in ESCC, but its detailed role in ESCC has not been explored. +circRNA target 35650643 hsa-mir-23a Carcinoma, Ovarian Epithelial Furthermore, it revealed that circRHOBTB3 could serve as the ceRNA of miR23a-3p to facilitate PTEN expression, suppress proliferation, G1/S transition, invasion, and promote apoptosis in EOC. +circRNA target 35650603 hsa-mir-449b Carcinoma, Pancreatic Ductal CONCLUSIONS: Our findings indicate that circSTX6 facilitates proliferation and metastasis of PDAC cells by regulating the expression of MYH9 through the circSTX6/miR-449b-5p axis and circSTX6/CUL2/HIF1A signaling pathway. +genetics_knock down_suppress 35650160 hsa-mir-93 Cardiomegaly Overall, MALAT1 knockdown ameliorated cardiac hypertrophy partly by regulating the miR5p/SIRT4 network, indicating that MALAT1 was a substantial indicator of cardiac hypertrophy. +lncRNA target 35650158 hsa-mir-335 Reperfusion Injury Moreover, SNHG15 regulated the TLR4/nuclear factor-kappaB (NF-kappaB) signaling pathway through miR +exosome 35649477 hsa-mir-197 Multiple Myeloma In conclusion, MM-exosomes could inhibit cardiomyocyte viability and promote apoptosis partially through circ-CACNG2/miR3p/caspase3 axis. +circulation_biomarker_diagnosis_ns 35649328 hsa-mir-146a Lupus Erythematosus, Systemic We investigated three EV biomarkers, namely, programmed cell death protein-1 (PD-1), microRNA-146a (miRNA-146a) and sialic acid (SA), in serum and urine from SLE patients and healthy controls. +genetics_overexpression_promote 35649317 hsa-mir-520a Leukemia, Myeloid, Acute CONCLUSION: Overexpression miR-520a-3p inhibited AML cell proliferation, and promoted apoptosis via inhibiting MUC1 expression and repressing Wnt/beta-catenin pathway activation. +genetics_GWAS 35648632 hsa-mir-1270 Pre-Eclampsia Our findings suggest that downregulation of miR-1270 contributes to impaired ECFC function via the associated ATM overexpression, which further identifies ATM as a novel and critical factor for ECFC defects in preeclampsia. +genetics_overexpression_promote 35648436 hsa-mir-155 Breast Neoplasms Despite the great progress in the control of primary tumor growth, metastasis remains the major challenge of breast cancer therapy in clinics, which is highly related to the upregulation of reactive oxygen species (ROS) and overexpression of its relevant pro-survival miR-155 gene. Therefore, we fabricated a poly-antioxidant (FTP) to deliver anti-miR-155 for synergistic treatment of metastatic breast cancer by ROS scavenging and miR-155 inhibition. +lncRNA target 35648221 hsa-mir-26b Osteosarcoma RESULTS: CircPVT1 and CCNB1 were significantly upregulated in OS cells, while miR-26b-5p was downregulated. CONCLUSION: Silencing of circPVT1 notably suppressed the tumorigenesis and metastasis of OS via miR-26b-5p/CCNB1 axis. +transcription factor target 35648115 hsa-mir-765 Breast Neoplasms TRG16, negatively regulated by miR-765, may inhibit the BC progression through regulating BC stem cell-like properties and this inhibition may be mediated by the NF-B pathway. +lncRNA target 35647304 hsa-mir-22 Epilepsy 5p significantly inhibited the TLR4/TRAF6/NF-kappaB-associated inflammation and reduced neuronal apoptosis, suggesting that its induction may be of potential interest for novel antiseizure medications. +target gene 35647303 hsa-mir-1273h Stomach Neoplasms miR-1273h-5p suppresses CXCL12 expression and inhibits gastric cancer cell invasion and metastasis. +genetics_overexpression_promote 35647294 hsa-mir-197 Colonic Neoplasms 3p overexpression and DKC1 restoration on regulating CC cell functions and L-OHP resistance. +transcription factor target 35647205 hsa-mir-326 Skin Diseases 3p mimic/inhibitor and siRNA-TLR4 can demonstrate a nonnegligible link between miR +lncRNA target 35647200 hsa-mir-671 Osteoarthritis These results suggested that DLEU1 acts as one destructive role in OA development via regulating miR +other 35647022 hsa-mir-497 Breast Neoplasms Thus, the current study aimed to investigate the correlation of miR-497/FGF-23 with neoadjuvant/adjuvant trastuzumab-induced cardiotoxicity in human epidermal growth factor receptor 2 (HER2)-positive breast cancer patients. CONCLUSION: The MiR-497/FGF-23 axis serves as a potential indicator predicting trastuzumab-induced cardiotoxicity in HER2-positive breast cancer patients. +other 35647022 hsa-mir-497 Cardiotoxicity Thus, the current study aimed to investigate the correlation of miR-497/FGF-23 with neoadjuvant/adjuvant trastuzumab-induced cardiotoxicity in human epidermal growth factor receptor 2 (HER2)-positive breast cancer patients. CONCLUSION: The MiR-497/FGF-23 axis serves as a potential indicator predicting trastuzumab-induced cardiotoxicity in HER2-positive breast cancer patients. +circulation_biomarker_diagnosis_up 35646947 hsa-mir-503 Kidney Diseases CONCLUSION: The serum levels of miRNA +lncRNA target 35646922 hsa-mir-4316 Adenocarcinoma of Lung Conclusion: Our present research suggested that LUCAT1 facilitate LUAD cell metastasis and glycolysis via serving as a competing endogenous RNA to regulate miR-4316/VEGFA axis, which provided a novel diagnostic marker and therapeutic target for LUAD patients. +lncRNA target 35646686 hsa-let-7f Colorectal Neoplasms In summary, FAM222A-AS1, as a novel oncogene in CRC, may promote the CRC progression by inhibiting miR-let-7f/MYH9 axis. The FAM222A-AS1/miR-let-7f/MYH9 signaling pathway may be a novel valuable target for inhibiting CRC. +other 35646670 hsa-mir-101 Adenocarcinoma of Lung 3p and a higher expression of ESPL1, AURKB, BUB3, and FAM83D, were associated with adverse clinical outcomes in patients with LUAD. +other 35646642 hsa-mir-6875 Urinary Bladder Neoplasms 5p, COL6A1, and CDH11, were measured in accordance with DE analysis in LCS-BCa, compared with normal bladder urothelium. +other 35646642 hsa-mir-6784 Urinary Bladder Neoplasms 5p, COL6A1, and CDH11, were measured in accordance with DE analysis in LCS-BCa, compared with normal bladder urothelium. +genetics_overexpression_promote 35646642 hsa-mir-6785 Urinary Bladder Neoplasms Overexpression of LINC01929 promoted bladder cancer development, while overexpression of miR5p inhibited bladder cancer development. +genetics_overexpression_promote 35646622 hsa-mir-155 high grade glioma RESULTS: We found a plasma miRNA signature including three downexpressed miRNAs and one overexpressed (miR-181a, miR-181b and miR-410; miR-155) in high-grade glioma patients in comparison with low-grade glioma patients control group. +genetics_overexpression_promote 35646622 hsa-mir-410 high grade glioma RESULTS: We found a plasma miRNA signature including three downexpressed miRNAs and one overexpressed (miR-181a, miR-181b and miR-410; miR-155) in high-grade glioma patients in comparison with low-grade glioma patients control group. +genetics_overexpression_promote 35646622 hsa-mir-181b high grade glioma RESULTS: We found a plasma miRNA signature including three downexpressed miRNAs and one overexpressed (miR-181a, miR-181b and miR-410; miR-155) in high-grade glioma patients in comparison with low-grade glioma patients control group. +genetics_overexpression_promote 35646622 hsa-mir-181a high grade glioma RESULTS: We found a plasma miRNA signature including three downexpressed miRNAs and one overexpressed (miR-181a, miR-181b and miR-410; miR-155) in high-grade glioma patients in comparison with low-grade glioma patients control group. +genetics_overexpression_promote 35646516 hsa-mir-4735 Carcinoma, Renal Cell 3p, and SLC40A1 overexpression significantly attenuated iron overload and ferroptosis in the miR +exosome 35646124 hsa-mir-223 Reperfusion Injury, Renal Ischemia CONCLUSION: In conclusion, the protective role of BMSC-derived EVs and exosome-delivered miR3p in RIRI was validated. +genetics_knock down_promote 35646117 hsa-mir-653 Thyroid Cancer, Papillary Knockdown of circNRIP1 attenuated the PTC tumor progression via miR +target gene 35646112 hsa-mir-543 Esophageal Neoplasms circRNA TCFL5 Promote Esophageal Cancer Progression by Modulating M2 Macrophage Polarization via the miR-543-FMNL2 Axis. +other 35645614 hsa-mir-133a-1 Tendinopathy CONCLUSIONS: Seven important lncRNAs, particularly MIR133A1HG and C10orf71-AS1, were found associated with tendinopathy according to the lncRNA-associated ceRNA network. +other 35645131 hsa-mir-499 Stomach Neoplasms Increasing studies have suggested that miR-146a, miR-196a2, and miR-499 play important roles in the development processes of gastric cancer (GC). +genetics_GWAS 35645131 hsa-mir-146a Stomach Neoplasms Further stratified analysis with regard to clinical-pathological parameters of GC patients indicated that miR-146a rs2910164 SNP was strongly associated with age (OR = 0.53, P = 0.001) and gender (OR = 0.61, P = 0.006). +other 35645131 hsa-mir-196a-2 Stomach Neoplasms Increasing studies have suggested that miR-146a, miR-196a2, and miR-499 play important roles in the development processes of gastric cancer (GC). +transcription factor target 35644411 hsa-mir-27a Scleroderma, Systemic MiR-27a-3p/SPP1/ERK1/2 axis may be an important target for delaying the progression of SSc fibrosis. +lncRNA target 35644224 hsa-mir-92b Stomach Neoplasms CONCLUSIONS: Circ-MYBL2 may absorb precursor miR-92b in the nucleus to suppress its role in promoting gastric cancer cell proliferation. +lncRNA target 35644004 hsa-mir-141 Reperfusion Injury, Hepatic Ischemia 3p plays a major role in hepatic IRI through the Keap1 signaling pathway, and the present study suggests that miR +lncRNA target 35643814 hsa-mir-25 Glioma In conclusions, Exo-circBTG2 secreted from RBP-J OE Mphi inhibits tumor progression through the circBTG2/miR3p/PTEN pathway, and circBTG2 is probably a diagnostic biomarker and potential target for glioma therapy. +transcription factor target 35643269 hsa-mir-223 Aortic Aneurysm, Abdominal loaded nanoparticles targeting macrophage polarization may mitigate AAA progression via downregulating of NLRP3. +other 35642971 hsa-mir-22 Endometrial Hyperplasia Our findings indicate that balloons coated with PEI/PAA/miR-22 have great potential to be promising DCBs in the treatment of cardiovascular disease. +circulation_biomarker_diagnosis_ns 35642704 hsa-mir-451a Multiple Myeloma RESULTS: In the plasma of patients with MM, miR-451a expression was low and IL-6R expression was high. +genetics_overexpression_promote 35642665 hsa-mir-423 Fibrosis, Airway In summary, overexpression of miR4235P promoted the EMT process in AF by downregulating FOXP4 expression and the underlying mechanism may partly involve activation of the PI3K/AKT/mTOR pathway. +transcription factor target 35642054 hsa-mir-189 Triple Negative Breast Neoplasms RESULTS: Although c-MYC is not a predicted gene target for miR +circulation_biomarker_diagnosis_up 35641805 hsa-mir-452 Brain Injuries 3p expression; reduced the neurological score; increased blood-brain barrier permeability, brain water content, and neuronal apoptosis; elevated pro-inflammatory factors; and reduced anti-inflammatory factors. +circulation_biomarker_diagnosis_up 35641805 hsa-mir-452 Subarachnoid Hemorrhage 3p expression; reduced the neurological score; increased blood-brain barrier permeability, brain water content, and neuronal apoptosis; elevated pro-inflammatory factors; and reduced anti-inflammatory factors. +genetics_overexpression_promote 35641154 hsa-mir-584 Carcinoma, Non-Small-Cell Lung Rescue function experiments corroborated that the anticancer activities of TFAP2A AS1 deficient on the oncogenicity of NSCLC cells were reversed by downregulating miR 584 3p or overexpressing CDK4. To sum up, TFAP2A AS1 exhibits cancer promoting roles in NSCLC through the adjustment of miR 584 3p/CDK4 axis. +lncRNA target 35641124 hsa-mir-124 Arthritis, Rheumatoid OBJECTIVE: This phase 2a randomised, double blind, placebo controlled, parallel group study evaluated the safety and efficacy of a first-in-class drug candidate ABX464 (obefazimod, 50 mg and 100 mg per day), which upregulates the biogenesis of the mRNA inhibitor micro-RNA (miR)-124, in combination with methotrexate (MTX) in 60 patients (1:1:1 ratio) with moderate-to-severe active rheumatoid arthritis (RA) who have inadequate response to MTX or/and to an anti-tumour necrosis factor alpha (TNFalpha) therapy. +lncRNA target 35640631 hsa-mir-590 Stomach Neoplasms 5p, thus inhibiting the progression of GC. +genetics_knock down_promote 35640247 hsa-let-7 Anovulation To investigate the functional role of lncR17454, dsRNAs of lncR17454 were injected into the hemolymph of 1-d-old third-instar larvae of Bombyx mori, repression of lncR17454 led to molting arrestment during the larval-larval and larval-pupal transition of silkworm, which was consistent to the result as let-7 knockdown in other studies. +other 35639779 hsa-mir-105 Liver Neoplasms Specifically, in liver and lung cancers, high expression of miR-105 and miR-767 was indicative of poor prognosis. +other 35639779 hsa-mir-767 Liver Neoplasms Specifically, in liver and lung cancers, high expression of miR-105 and miR-767 was indicative of poor prognosis. +other 35639251 hsa-mir-4697 Ovarian Neoplasms In the end, we validated the expression, regulation, binding, and effect on chemotherapy response for selected MNX1-AS1/hsa-miR3p/HOXB13 in OC cell lines. +genetics_overexpression_suppress 35639219 hsa-mir-143 Carcinoma, Non-Small-Cell Lung USP28 overexpression partly overturned the inhibitory effect of miR +other 35639035 hsa-mir-29b Stomach Neoplasms Patients with cancer had the lowest expression of miR-29b in stomach body and it was the highest in the patients with inactive gastritis in this location. +other 35639035 hsa-mir-106b Stomach Neoplasms Expression of miR-106b in the antrum and body was the highest in the group of cancer patients and the lowest in patients with chronic active gastritis. +other 35638909 hsa-mir-208b Myocardial Infarction Results and Conclusion: Several miRNAs were elevated in MI patients, including miR-208b, miR-499, and miR-375. +other 35638909 hsa-mir-499 Myocardial Infarction Results and Conclusion: Several miRNAs were elevated in MI patients, including miR-208b, miR-499, and miR-375. +genetics_knock down_promote 35638591 hsa-mir-130a Angelman Syndrome After that, the knockdown of FAS and overexpression of miR-130a-5p together were observed to aggregate ox-LDL-induced reduction of cell viability and apoptosis, cell cycle progression, cell proliferation, cell migration and invasion. +lncRNA target 35638462 hsa-mir-133b Pancreatic Carcinoma Therefore, we propose that targeting the lncRNA-TTN-AS1/miR-133b/SQLE axis is expected to provide new ideas for the clinical treatment of PC patients. +other 35638388 hsa-mir-1290 Asthma miR-1290 was associated with asthma and atopy during pregnancy (p < 0.05; |B(regression)| >0.2). +lncRNA target 35637792 hsa-mir-19a Respiratory Syncytial Virus Infections CONCLUSIONS: These results suggested that the RSV NS1 might play an important role in the pathogenesis of RSV by activating the 5-LO and subsequent inflammatory cytokines through miR-19a-3p. +circulation_biomarker_diagnosis_up 35637648 hsa-mir-15b Obesity Circulating miR-15b, Annexin A1, procalcitonin and interleukin-6 levels The present study assessed serum miR-15b, Annexin A1, procalcitonin, and interleukin-6 (IL-6) levels in children with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) and compared them to these levels in a non-obese healthy control group. In conclusion, determination of serum miR-15b, Annexin A1, and procalcitonin levels could differentiate children with MUO from those with MHO. +lncRNA target 35637630 hsa-mir-27a Carcinoma, Hepatocellular Above results suggest that the abnormally over-expressed miR-27a-3p in liver promotes the proliferation of cancer cells and accelerates the development of HCC by targeting inhibition the expression of USP46. +exosome 35637388 hsa-mir-539 Inflammatory Bowel Diseases CONCLUSION: The present study demonstrated that BMSCs-derived exosomal miR5p suppresses pyroptosis through NLRP3/caspase-1 signalling to inhibit IBD progression. +lncRNA target 35636640 hsa-mir-760 Brain Ischemia CONCLUSIONS: circNup188 might up-regulate Map3k8 expression through sponging miR +transcription factor target 35636636 hsa-mir-223 Kidney Calculi CONCLUSION: The expression of miR3p is significantly higher in urinary sEVs derived from CaOx stone patients and may affect stone formation via regulating oxidative stress, focal adhesion and inflammation process. +transcription factor target 35636172 hsa-mir-24 Carcinoma, Renal Cell Overall, our results suggested that ICS II-induced ferroptosis via the miR3p/GPX4 axis in RCC cells could be a promising therapeutic agent for RCC. +circulation_biomarker_diagnosis_ns 35636162 hsa-let-7a Pneumonia, Mycoplasma In addition, recent studies identified some miRNAs that are differentially expressed in the blood of PE patients, which might be used as a diagnostic biomarker for PE, including let-7a-5p, let-7b-5p, and miR5p. +circulation_biomarker_diagnosis_ns 35636162 hsa-mir-150 Pneumonia, Mycoplasma In addition, recent studies identified some miRNAs that are differentially expressed in the blood of PE patients, which might be used as a diagnostic biomarker for PE, including let-7a-5p, let-7b-5p, and miR5p. +circulation_biomarker_diagnosis_ns 35636162 hsa-let-7b Pneumonia, Mycoplasma In addition, recent studies identified some miRNAs that are differentially expressed in the blood of PE patients, which might be used as a diagnostic biomarker for PE, including let-7a-5p, let-7b-5p, and miR5p. +other 35635974 hsa-mir-122 Chemical and Drug Induced Liver Injury In conclusion, the optimized arrangements of our EIS biosensor system enabled us to detect microRNA-122, a known biomarker for liver injury, as well as three common isoforms to a 1 nM (equivalent to 80 fmole) detection limit. +circulation_biomarker_diagnosis_up 35635855 hsa-mir-125b Pre-Eclampsia RESULTS: ET-1 messenger RNA expression levels and immunoreactivity were found significantly higher in the PE group while microRNA-1 and microRNA-125b (miR-125b) levels were significantly decreased in placenta compared to control. miR-125b levels were found significantly higher in maternal and umbilical cord blood samples of the PE group. +lncRNA target 35635748 hsa-mir-524 Thyroid Cancer, Papillary In addition, NEAT1 promoted PTC development by regulating ID1 expression via sponging miR +lncRNA target 35635083 hsa-mir-378a Tendinopathy Our results therefore indicate that targeting the MALAT1/miR-378a-3p/MAPK1 axis may be a promising avenue for the treatment of tendinopathy. +lncRNA target 35635081 hsa-mir-1323 Osteoarthritis Collectively, the results showed that ZFAS1 promoted chondrocyte proliferation and repressed oxidative stress, possibly by regulating the novel miRNrf2 axis of the inflammation and apoptosis triggered by LPS, indicating that ZFAS1 is a promising therapeutic target for OA. +circulation_biomarker_diagnosis_up 35635080 hsa-mir-532 Cardiomegaly KaplanMeier and multivariate Cox regression analysis suggested that low ACR predicted overall survival of CHF patients and ACR was inversely correlated with miR-532 across plasma samples. +transcription factor target 35635065 hsa-mir-122 Arthritis 3p represses RA progression by reducing cell viability and increasing synoviocyte apoptosis. +lncRNA target 35635053 hsa-mir-153 Squamous Cell Carcinoma of Head and Neck 3p/AGK axis.Abbreviations: OSCC: Oral squamous cell carcinoma; AGK: Acylgycerol kinase; CircRNA: Circular RNA; KATNAL1: Katanin p60 ATPase-containing subunit A-like 1; qRT-PCR: Quantitative real-time polymerase chain reaction; miRNAs/miRs: MicroRNAs; RIP: RNA immunoprecipitation; 3'UTR3': -untranslated region; HK2: Hexokinase 2; LDHA Lactate dehydrogenase A; IHC: Immunohistochemistry; CCK8: Cell counting kit-8; GAPDH: Glyceraldehyde +other 35635016 hsa-mir-205 Rhinitis, Allergic miR5p plays a vital role in the inflammation of allergic rhinitis (AR). +other 35634846 hsa-mir-128 Neuroblastoma 3p and TERT represent a novel prognostic biomarker for neuroblastoma. +circulation_biomarker_prognosis_up 35634597 hsa-mir-21 Ovarian Neoplasms CONCLUSION: Elevated expression of miR-21, HE4, and CA125 in serum is closely associated with the disease status of ovarian cancer. +genetics_knock down_promote 35634507 hsa-mir-1278 Deficiency Diseases Of those miRNAs that were upregulated with estrogen deficiency and downregulated after estrogen therapy, miR-422a correlated with serum beta-carboxy-terminal type I collagen crosslinks (beta-CTX) and procollagen 1 N-terminal propeptide (P1NP); and miR-1278 correlated with serum beta-CTX, P1NP, osteocalcin, sclerostin, and Dickkopf-1(Dkk1). +exosome 35634460 hsa-mir-155 Heat Stroke CONCLUSION: Increased miR-155 in microglial exosomes after heat stroke can induce neuronal autophagy via their transfer into neurons. Therefore, miR-155 could be a promising target for interventions of neuronal autophagy after heat stroke. +circRNA target 35634241 hsa-mir-520c Carcinoma, Non-Small-Cell Lung RESULTS: The study revealed functional prominence on miR-520c-3p, down-regulated during NSCLC. CONCLUSIONS: The therapeutic usage by designing a synthetic circuit of miR-520c-3p was explored, which may help in suppressing tumors in NSCLC. +lncRNA target 35633990 hsa-mir-802 Breast Neoplasms In this study, we investigated the probable molecular functions that are related to microRNA-802 (miR-802) and evaluated its prognostic value in breast cancer utilizing bioinformatics tools. Furthermore, representing candidate target genes by prognostic values indicates the potential clinical application of miR-802 in breast cancer. +genetics_GWAS 35633562 hsa-mir-196a-2 Ovarian Neoplasms So, miR-196a-2 polymorphism can be a possible prognostic factor in ovarian cancer. +genetics_overexpression_suppress 35633539 hsa-mir-191 Carcinoma, Non-Small-Cell Lung It appears that a therapy to overexpress miR-1 and miR-133 and downexpress miR-191 and miR-24 could contribute to the treatment of lung cancer. +genetics_overexpression_suppress 35633539 hsa-mir-24 Carcinoma, Non-Small-Cell Lung It appears that a therapy to overexpress miR-1 and miR-133 and downexpress miR-191 and miR-24 could contribute to the treatment of lung cancer. +genetics_overexpression_suppress 35633539 hsa-mir-133 Carcinoma, Non-Small-Cell Lung It appears that a therapy to overexpress miR-1 and miR-133 and downexpress miR-191 and miR-24 could contribute to the treatment of lung cancer. +genetics_overexpression_suppress 35633539 hsa-mir-1 Carcinoma, Non-Small-Cell Lung It appears that a therapy to overexpress miR-1 and miR-133 and downexpress miR-191 and miR-24 could contribute to the treatment of lung cancer. +other 35633501 hsa-mir-223 Demyelinating Diseases Herein, we investigated the NLRP3 (NBD-, LRR- and pyrin domain-containing protein 3) inflammasome and its endogenous regulator microRNA3p within the demyelinated CNS in both MS and an animal model of focal demyelination. +other 35633501 hsa-mir-223 Multiple Sclerosis Herein, we investigated the NLRP3 (NBD-, LRR- and pyrin domain-containing protein 3) inflammasome and its endogenous regulator microRNA3p within the demyelinated CNS in both MS and an animal model of focal demyelination. +lncRNA target 35632705 hsa-mir-28 Hamartoma Syndrome, Multiple Our results suggest that MINCR might regulate the expression of RAP1B through the inhibition of miR +transcription factor target 35632672 hsa-mir-122 Sveinsson Chorioretinal Atrophy The increased MIR122HG expression inhibited the production of the antiviral immune-related genes IFN-1, ISG15 and Viperin upon SCRV treatment. Additionally, we found that MIR122HG can promote the replication of SCRV. +other 35632672 hsa-mir-122 Immune System Diseases In addition, MIR122HG can act as a pivotally negative regulator involved in the MAVS-mediated NF-kappaB and IRF3 signaling pathways, which can effectively avoid an excessive immune response. +target gene 35631544 hsa-mir-145 Ovarian Neoplasms Peptide Targeted Gold Nanoplatform Carrying miR-145 Induces Antitumoral Effects in Ovarian Cancer Cells. +circulation_biomarker_diagnosis_up 35629399 hsa-mir-486 Prostatic Neoplasms Our study aimed to assess the applicability of miR-486 in combination with soluble GP88 protein as a diagnostic and/or predictive biomarker for prostate cancer (PCa) patients. Altogether, combined miR-486 and GP88 serum levels are associated with and are therefore suggested as supportive biomarkers for therapy decisions, particularly in elderly PCa patients. +lncRNA target 35628650 hsa-mir-195 Inflammatory Bowel Diseases In conclusion, our data revealed the role of miR5p in intestinal inflammation in ulcerative colitis, suggesting a potential pharmacological target for new therapeutic approaches. +other 35628433 hsa-mir-22 Uterine Cervical Neoplasms MiR3p might be a metastamiR, which was gradually further downregulated in SqC-NM > SqC-M > ML-SqC. +genetics_GWAS 35628426 hsa-mir-499 Cardiovascular Diseases In the STAT cohort, nine SNPs (in the MIR499, CETP, CYP2C9, IL6, ABCC2, PON1, IL10, and VEGFA genes) were associated with lipid traits, three of which were in common with the TN cohort. +genetics_GWAS 35628426 hsa-mir-499a Cardiovascular Diseases In the STAT cohort, nine SNPs (in the MIR499, CETP, CYP2C9, IL6, ABCC2, PON1, IL10, and VEGFA genes) were associated with lipid traits, three of which were in common with the TN cohort. +transcription factor target 35628416 hsa-mir-210 Carcinoma, Renal Cell Data previously generated in ccRCC cell lines demonstrating that miR-210, miR-155, and HIFs are druggable targets using a defined dose and schedule of selenium-containing molecules support the concept that simultaneous and concurrent downregulation of miR-210, miR-155, and HIFs, which regulate target genes associated with increased tumor angiogenesis and drug resistance, may offer the potential for the development of a novel mechanism-based strategy for the treatment of patients with advanced ccRCC. +transcription factor target 35628416 hsa-mir-155 Carcinoma, Renal Cell Data previously generated in ccRCC cell lines demonstrating that miR-210, miR-155, and HIFs are druggable targets using a defined dose and schedule of selenium-containing molecules support the concept that simultaneous and concurrent downregulation of miR-210, miR-155, and HIFs, which regulate target genes associated with increased tumor angiogenesis and drug resistance, may offer the potential for the development of a novel mechanism-based strategy for the treatment of patients with advanced ccRCC. +lncRNA target 35628336 hsa-mir-29a Uterine Cervical Neoplasms Herein, we established two pairs of parental wild-type (WT) and radioresistant (RR) cervical cancer cells (CaSki and C33A), and we found that constant suppressed miR-29a, but not miR-29b/c, was exhibited in RR-clones that underwent a dose of 6-Gy radiation treatment. +other 35628294 hsa-mir-126 Breast Neoplasms We have previously shown that physiological delivery of platelet MVs enriched in miR-126 exerted anti-tumor effects in different breast cancer (BC) cell lines. +circulation_biomarker_diagnosis_up 35628259 hsa-mir-370 Sepsis BAM15 attenuated sepsis as indicated by survival, organ histology (kidneys and livers), spleen apoptosis (activated caspase 3), brain injury (SHIRPA score, serum s100beta, serum miR370-3p, brain miR370-3p, brain TNF-alpha, and apoptosis), systemic inflammation (cytokines, cell-free DNA, endotoxemia, and bacteremia), and blood-brain barrier (BBB) damage (Evan's blue dye and the presence of green fluorescent E. +circulation_biomarker_diagnosis_up 35628259 hsa-mir-370 Sepsis-Associated Encephalopathy BAM15 attenuated sepsis as indicated by survival, organ histology (kidneys and livers), spleen apoptosis (activated caspase 3), brain injury (SHIRPA score, serum s100beta, serum miR370-3p, brain miR370-3p, brain TNF-alpha, and apoptosis), systemic inflammation (cytokines, cell-free DNA, endotoxemia, and bacteremia), and blood-brain barrier (BBB) damage (Evan's blue dye and the presence of green fluorescent E. +transcription factor target 35628233 hsa-mir-29c Liver Cirrhosis The antifibrotic activities of SCNPs were mediated by suppressing the expression of the main fibrosis mediators TGFbetaR1, COL3A1, and TGFbetaR2 by boosting the hepatic expression of protective miRNAs; miR-22, miR-29c, and miR-219a, respectively. +transcription factor target 35628233 hsa-mir-219a Liver Cirrhosis The antifibrotic activities of SCNPs were mediated by suppressing the expression of the main fibrosis mediators TGFbetaR1, COL3A1, and TGFbetaR2 by boosting the hepatic expression of protective miRNAs; miR-22, miR-29c, and miR-219a, respectively. +transcription factor target 35628233 hsa-mir-22 Liver Cirrhosis The antifibrotic activities of SCNPs were mediated by suppressing the expression of the main fibrosis mediators TGFbetaR1, COL3A1, and TGFbetaR2 by boosting the hepatic expression of protective miRNAs; miR-22, miR-29c, and miR-219a, respectively. +other 35628106 hsa-mir-20 Coronary Artery Disease Among the 14 differentially expressed microRNAs in epicardial fat between patients with and without coronary artery disease, the hsa-miR-320 family was the most highly represented. +other 35627270 hsa-mir-1293 Adenocarcinoma of Lung CONCLUSIONS: hsa_circ_0008234/hsa-miR3p/SYT1 and hsa_circ_0002360/hsa-miR-1293/ (ADCY9, NMUR1) networks were established, and identified molecules may be involved in pathogenesis and prognosis in patients with LUAD. +other 35627270 hsa-mir-490 Adenocarcinoma of Lung CONCLUSIONS: hsa_circ_0008234/hsa-miR3p/SYT1 and hsa_circ_0002360/hsa-miR-1293/ (ADCY9, NMUR1) networks were established, and identified molecules may be involved in pathogenesis and prognosis in patients with LUAD. +other 35627262 hsa-mir-101 Carcinoma, Hepatocellular CONCLUSION: SNHG6 or MALAT1/hsa-miR3p/EZH2 axis were identified as potential regulatory pathways in the progression of HCC. +other 35627259 hsa-mir-143 Colorectal Neoplasms CONCLUSIONS: miR-143 may be associated with the development of colorectal cancer. +circRNA target 35627232 hsa-mir-205 Lung Neoplasms This study revealed that hsa_circ_0006692 promoted NSCLC progression via enhancing cell growth, invasion, and metastasis through sponging mir +circulation_biomarker_diagnosis_ns 35627221 hsa-mir-29b Lung Neoplasms A total of 132 lung cancer patients and 132 healthy controls were recruited to measure miR-29b and DNMT3B mRNA expression in whole blood. +other 35627132 hsa-mir-4513 Coronary Artery Disease The study is aimed to investigate the impact of rs895819, rs11614913, and rs2168518 variants in MIR27A, MIR196A2, and MIR4513, respectively, in CAD using allele-specific PCR. +other 35626751 hsa-mir-423 Fibrosis In addition, miR5p was shown to be involved in HSCs differentiation and hence, fibrosis development. +lncRNA target 35626709 hsa-mir-18a Breast Neoplasms A microarray-based gene expression analysis performed in miR-18a over-expressed ER+ breast cancer cell lines demonstrated dysregulation and suppression of immune-related pathways. +exosome 35626040 hsa-mir-625 Carcinoma, Non-Small-Cell Lung EV-miR5p is an independent biomarker of response and survival in ICI-treated NSCLC patients, in particular in patients with PD-L1 expression >/=50%. +circulation_biomarker_prognosis_ns 35625994 hsa-mir-200c Breast Neoplasms Our findings suggest that plasmatic miR-200c-3p levels could be useful for BC staging, while the tumor expression of miR-200c-3p might provide further prognostic information beyond residual disease in BC treated with neoadjuvant chemotherapy. +other 35625926 hsa-mir-140 Endometrial Neoplasms 3-changed their expressions regardless of the chemotherapeutic agent used, which suggests the possibility of their use in monitoring the severity of oxidative stress in endometrial cancer. +other 35625926 hsa-mir-144 Endometrial Neoplasms 3-changed their expressions regardless of the chemotherapeutic agent used, which suggests the possibility of their use in monitoring the severity of oxidative stress in endometrial cancer. +target gene 35625769 hsa-mir-16 Colorectal Neoplasms Carbonic Anhydrase VIII (CAVIII) Gene Mediated Colorectal Cancer Growth and Angiogenesis through Mediated miRNA 16-5p. +other 35625530 hsa-mir-34a Alopecia Areata In conclusion, the MIR34A rs2666433 (A/G) variant is associated with AA risk and severity in the studied population. +other 35625525 hsa-mir-5144 Dehydration The most notable among these were found to be miR5493-OsSLAC and miR5144-OsLOG1 for enhanced panicle size, miR5493-OsBRITTLE1-1 for grain formation, miR6245-OsCsIF9 for decreased stem mechanical strength, miR5487-OsGns9 and miR168b-OsCP1 for better pollen development, and miR172b-OsbHLH153 for hyponasty under shade. +other 35625525 hsa-mir-5493 Dehydration The most notable among these were found to be miR5493-OsSLAC and miR5144-OsLOG1 for enhanced panicle size, miR5493-OsBRITTLE1-1 for grain formation, miR6245-OsCsIF9 for decreased stem mechanical strength, miR5487-OsGns9 and miR168b-OsCP1 for better pollen development, and miR172b-OsbHLH153 for hyponasty under shade. +other 35625525 hsa-mir-5487 Dehydration The most notable among these were found to be miR5493-OsSLAC and miR5144-OsLOG1 for enhanced panicle size, miR5493-OsBRITTLE1-1 for grain formation, miR6245-OsCsIF9 for decreased stem mechanical strength, miR5487-OsGns9 and miR168b-OsCP1 for better pollen development, and miR172b-OsbHLH153 for hyponasty under shade. +other 35625525 hsa-mir-172b Dehydration The most notable among these were found to be miR5493-OsSLAC and miR5144-OsLOG1 for enhanced panicle size, miR5493-OsBRITTLE1-1 for grain formation, miR6245-OsCsIF9 for decreased stem mechanical strength, miR5487-OsGns9 and miR168b-OsCP1 for better pollen development, and miR172b-OsbHLH153 for hyponasty under shade. +other 35625525 hsa-mir-6245 Dehydration The most notable among these were found to be miR5493-OsSLAC and miR5144-OsLOG1 for enhanced panicle size, miR5493-OsBRITTLE1-1 for grain formation, miR6245-OsCsIF9 for decreased stem mechanical strength, miR5487-OsGns9 and miR168b-OsCP1 for better pollen development, and miR172b-OsbHLH153 for hyponasty under shade. +other 35625525 hsa-mir-168b Dehydration The most notable among these were found to be miR5493-OsSLAC and miR5144-OsLOG1 for enhanced panicle size, miR5493-OsBRITTLE1-1 for grain formation, miR6245-OsCsIF9 for decreased stem mechanical strength, miR5487-OsGns9 and miR168b-OsCP1 for better pollen development, and miR172b-OsbHLH153 for hyponasty under shade. +other 35624761 hsa-mir-873 Dehydration In our study, we demonstrate a GNMT and methionine cycle activity restoration by the anti-miR5p that reduces mitochondrial dysfunction and oxidative stress. +other 35624761 hsa-mir-873 Mitochondrial Diseases 5p appears to be an effective therapy against APAP-induced liver injury, where the restoration of GNMT and the methionine cycle may prevent mitochondrial dysfunction while activating hepatocyte proliferative response. +other 35624761 hsa-mir-873 Chemical and Drug Induced Liver Injury In summary, anti-miR5p appears to be an effective therapy against APAP-induced liver injury, where the restoration of GNMT and the methionine cycle may prevent mitochondrial dysfunction while activating hepatocyte proliferative response. +other 35624629 hsa-mir-21 Neoplasms, Multiple Primary By monitoring slight increases in miRNA-21 levels, the possibilities of multi-type malignancy can be evaluated more precisely and earlier. +transcription factor target 35624466 hsa-mir-22 Polyposis Syndrome, Hereditary Mixed, 1 Inhibition of miR3p or ectopic MDC1 expression reversed the increased senescence, DNA damage, CIN and defective HR observed in AP4-deficient CRC cells. +transcription factor target 35624466 hsa-mir-22 Colorectal Neoplasms Inhibition of miR +tissue_expression_ns 35624466 hsa-mir-22 Canavan Disease AP4-deficiency also sensitized CRC cells to 5-FU treatment, whereas ectopic AP4 conferred resistance to 5-FU in a miR3p and MDC1-dependent manner. +genetics_GWAS 35624451 hsa-mir-31 Prostatic Neoplasms CONCLUSIONS: Our findings showed that the epigenetic regulator PRMT5 aggravates PCa progression by inhibiting the transcription of CAMK2N1 and is modulated by the circSPON2/miR +exosome 35624329 hsa-mir-144 Reperfusion Injury, Intestinal Ischemia CONCLUSIONS: BMSC-exos carrying miR +genetics_knock down_promote 35624316 hsa-mir-143 Squamous Cell Carcinoma of Head and Neck Knockdown of circPVT1 impeded OSCC progression via the miR +lncRNA target 35624111 hsa-mir-494 Spinal Cord Injuries This study identified a novel KLF2/lncRNA SNHG12/miR3p/RAD23B axis in SNI-induced neuropathic pain, which might provide a new insight for developing novel diagnosis, or therapeutic targets of SCI-induced neuropathic pain in the future. +lncRNA target 35624111 hsa-mir-494 Neuralgia This study identified a novel KLF2/lncRNA SNHG12/miR3p/RAD23B axis in SNI-induced neuropathic pain, which might provide a new insight for developing novel diagnosis, or therapeutic targets of SCI-induced neuropathic pain in the future. +genetics_overexpression_promote 35623612 hsa-mir-29a Corneal Injuries Overexpression of miR-29a and 381-5p significantly prevented M1 phenotype transition in RAW264.7 cells after lipopolysaccharide treatment, suppressed transforming growth factor 1-induced fibrosis marker expression in keratocytes, and reduced scarring after corneal injury. +other 35623291 hsa-mir-199a Arthritis, Rheumatoid RESULTS: Data showed that the expression level of MALAT1, H19, miR-199a-5p, and miR3p was significantly higher in the newly diagnosed patients with RA than the healthy subjects, but the increase in the expression level of HSPA5 and MMD genes in the new cases was not significant compared to healthy controls. +other 35623291 hsa-mir-1 Arthritis, Rheumatoid RESULTS: Data showed that the expression level of MALAT1, H19, miR-199a-5p, and miR3p was significantly higher in the newly diagnosed patients with RA than the healthy subjects, but the increase in the expression level of HSPA5 and MMD genes in the new cases was not significant compared to healthy controls. +lncRNA target 35622250 hsa-mir-1236 Stomach Neoplasms Our findings suggest that LINC00839 promotes GC progression through sponging miR3p. +transcription factor target 35622214 hsa-mir-338 Glioma Intriguingly, TPT1suppressed the miR-338 gene, which targets SMO in hESC-NSPCs and BTICs. +transcription factor target 35622213 hsa-mir-377 Squamous Cell Carcinoma of Head and Neck 3p-SESN1-SMAD3 regulatory axis that contributes to proliferation, migration, and invasion in HNSCC development, which may represent an interventional target for HNSCC therapy. +lncRNA target 35621109 hsa-mir-4728 Colorectal Neoplasms 5p as Tumor Suppressors in Pathogenesis of Colorectal MicroRNAs (miRNAs) are a class of small noncoding RNAs that have major functions in the development and progression of colorectal cancer (CRC) as tumor suppressors or oncogenes. +lncRNA target 35621109 hsa-mir-485 Colorectal Neoplasms 5p as Tumor Suppressors in Pathogenesis of Colorectal MicroRNAs (miRNAs) are a class of small noncoding RNAs that have major functions in the development and progression of colorectal cancer (CRC) as tumor suppressors or oncogenes. +other 35620639 hsa-mir-186 Myocardial Infarction CONCLUSION: Circ_ROBO2 played a promoting role in ox-LDL-induced CMECs injury by sponging miR5p and regulating TRIM14, providing a promising treatment strategy for CAD. +lncRNA target 35620576 hsa-mir-503 Myocardial Reperfusion Injury It is concluded that miR-503 exacerbated I/R injury via inactivation of PI3K/Akt and STAT3 pathways and may become a therapeutic target in preventing myocardial I/R injury. +other 35620289 hsa-mir-124 Nerve Degeneration This study is pioneer in elucidating that neuronal miR-124 reshapes microglia plasticity and in revealing the relevance of neuronal survival in mechanisms underlying inflammation in AD-associated neurodegeneration. +genetics_knock down_promote 35620289 hsa-mir-124 Sjogren's Syndrome Treatment of SWE cells with the miR-124 inhibitor led to RAGE overexpression and loss of neuronal viability, while the mimic caused RAGE/HMGB1 downregulation and prevented mitochondria membrane potential loss. +other 35620289 hsa-mir-124 Alzheimer Disease We also reported miR-124 colocalization with microglia in AD patient hippocampi. This study is pioneer in elucidating that neuronal miR-124 reshapes microglia plasticity and in revealing the relevance of neuronal survival in mechanisms underlying inflammation in AD-associated neurodegeneration. +circulation_biomarker_diagnosis_ns 35620197 hsa-mir-126 Intestinal Fistula CONCLUSIONS: These data confirm that circulating MMP9 can be used for the identification of cases with intra-abdominal fistulas and suggest that miR-126 may be also involved in the pathogenesis of this complication and that it may be further investigated as a new therapeutic strategy or for monitoring therapeutic response in these patients. +other 35619921 hsa-mir-93 Esophageal Squamous Cell Carcinoma 5p or the miR-106b-5p-SOCS4 axis may provide great potential in establishing ESCC therapy. +other 35619921 hsa-mir-106b Esophageal Squamous Cell Carcinoma 5p or the miR-106b-5p-SOCS4 axis may provide great potential in establishing ESCC therapy. +target gene 35619625 hsa-mir-130a Breast Neoplasms LncRNA HOTAIR promotes the proliferation and invasion/metastasis of breast cancer cells by targeting the miR-130a-3p/Suv39H1 axis. +genetics_knock down_suppress 35619575 hsa-mir-103a Colorectal Neoplasms Additionally, the effect of miR-103a-3p knockdown in CRC cells and the molecular mechanism of miR-103a-3p targeting GREM2 were also studied. +lncRNA target 35619281 hsa-mir-223 Multiple Sclerosis Our literature research showed that miR-223 could affect different pathways involved in M.S. MiR-223 was also identified as a potential biomarker, distinguishing relapsing-remitting multiple sclerosis (RRMS) from progressive multiple sclerosis (PMS), and thus, it may be an attractive target for further investigations. +lncRNA target 35619019 hsa-mir-520a uterine corpus endometrial carcinoma Our studies revealed that VPS9D1-AS1 contributed to the UCEC development and progression by binding to miR-520a-5p competitively and inducing BIRC5 expression, indicating that VPS9D1-AS1 might act as a therapeutic target to develop new therapies for UCEC patients. +genetics_knock down_promote 35618996 hsa-mir-221 Acute Kidney Injury Finally, knockdown of lncRNA ENSMUST_147219 markedly attenuated the ischemic AKI by targeting the miR +other 35617983 hsa-mir-1228 Carcinoma, Renal Cell hsa-let-7i-5p/hsa-miR5p-TRIM26-SNRPB was a potential mechanism axis that may play a role on the KIRC cells. +other 35617983 hsa-let-7i Carcinoma, Renal Cell hsa-let-7i-5p/hsa-miR5p-TRIM26-SNRPB was a potential mechanism axis that may play a role on the KIRC cells. +other 35617639 hsa-mir-101 Nerve Degeneration MiR-101 has been reported to be involved in neuroinflammation, neuronal injury and neurotoxicity. However, the specific role and mechanism of miR-101 in ischemia/reperfusion (I/R)-induced neuronal injury remain largely unknown. +other 35617639 hsa-mir-101 Neurotoxicity Syndromes MiR-101 has been reported to be involved in neuroinflammation, neuronal injury and neurotoxicity. +other 35617639 hsa-mir-101 Neurogenic Inflammation MiR-101 has been reported to be involved in neuroinflammation, neuronal injury and neurotoxicity. +other 35617639 hsa-mir-101 Reperfusion Injury However, the specific role and mechanism of miR-101 in ischemia/reperfusion (I/R)-induced neuronal injury remain largely unknown. +other 35617639 hsa-mir-101 Iron Metabolism Disorders However, the specific role and mechanism of miR-101 in ischemia/reperfusion (I/R)-induced neuronal injury remain largely unknown. +circulation_biomarker_diagnosis_up 35617369 hsa-mir-122 Hepatitis C, Chronic In conclusion, our findings confirm that serum miR-122 levels are significantly upregulated in the HCV cirrhotic patients serving in particular as a biomarker for the non-advanced stages of cirrhosis, independently of the HCV genotype. +circulation_biomarker_diagnosis_ns 35617312 hsa-mir-103a Larva Migrans, Visceral We investigated the expression levels of circulating miRNA 21 and miRNA 103a as potential biomarkers for the prediction and diagnosis of toxocariasis in Wistar rats infected with Toxocara canis.Methodology. +circulation_biomarker_diagnosis_ns 35617312 hsa-mir-21 Larva Migrans, Visceral We investigated the expression levels of circulating miRNA 21 and miRNA 103a as potential biomarkers for the prediction and diagnosis of toxocariasis in Wistar rats infected with Toxocara canis.Methodology. +other 35617207 hsa-mir-22 Brugada Syndrome 3p, and hsa-miR-23a-3p were independently associated with BrS (P < 0.0001). +other 35617207 hsa-mir-423 Brugada Syndrome 3p, and hsa-miR-23a-3p were independently associated with BrS (P < 0.0001). +other 35617207 hsa-mir-23a Brugada Syndrome 3p, and hsa-miR-23a-3p were independently associated with BrS (P < 0.0001). +other 35617207 hsa-mir-223 Brugada Syndrome 3p, and hsa-miR-23a-3p were independently associated with BrS (P < 0.0001). +lncRNA target 35617032 hsa-mir-185 Colorectal Neoplasms 5p/CCND2 axis may be targetable for CRC diagnosis and therapy. +genetics_overexpression_suppress 35616949 hsa-mir-7a Diabetic Neuropathies This study aimed to investigate the mechanism of miR-7a-5p in DPN. CONCLUSION: MiR-7a-5p overexpression ameliorated mitochondrial dysfunction and inhibited apoptosis in DPN by regulating VDAC1/JNK/c-JUN pathway. +genetics_GWAS 35616822 hsa-mir-144 Esophageal Squamous Cell Carcinoma These data suggest that LINC00886 may act as a tumor suppressor gene in ESCC and its down-regulation through epigenetic mechanisms promotes EMT process via SIRT7/ELF3/miR-144 pathway in ESCC. +circRNA target 35616807 hsa-mir-127 Colorectal Neoplasms Taken together, these findings indicated that hsa_circ_0006732 might be an oncogene in CRC through the regulation of the miR5p/RAB3D axis. +circulation_biomarker_diagnosis_ns 35616664 hsa-mir-21 Colorectal Neoplasms OBJECTIVE: This systematic analysis aimed to explore the individual efficacy of the most investigated blood-based miRNAs for CRC diagnosis, namely miR-21, miR-29a and miR-92a. Based on these findings, circulating miR-21 levels may have a potential value for early detection and might be used as a novel diagnostic biomarker for CRC. +transcription factor target 35616621 hsa-mir-342 Glioblastoma 3p/CDK6 might be a treatment target in glioblastoma development. +genetics_overexpression_promote 35616620 hsa-mir-145 Stomach Neoplasms However, tuftelin 1 overexpression attenuated the tumor-suppressive effect of miR-145 in MGC-803 gastric cancer cells. +lncRNA target 35616619 hsa-mir-942 Nasopharyngeal Carcinoma 3p could sensitize NPC to X-rays via a downstream target BARD1, offering potential new strategies for radiotherapy of NPC. +genetics_overexpression_promote 35616230 hsa-mir-612 Carcinoma, Renal Cell Migration and invasion of KIRC cells were promoted when the cells were transfected with LINC00174 overexpression or miR-612 inhibitor (p < .05). +lncRNA target 35616155 hsa-mir-2113 Prostatic Neoplasms The present study demonstrated that MNX1AS1 promoted prostate cancer progression through regulating miR2113/ MDM2 axis. +lncRNA target 35616132 hsa-mir-141 Femur Head Necrosis In conclusion, miR141 inhibits the osteogenic differentiation of BMSCs in ONFH by targeting E2F3. +lncRNA target 35615948 hsa-mir-145 Colonic Neoplasms 5p repressed colon cancer cell cycle progression and cell proliferation via targeting PSAT1. +exosome 35615580 hsa-mir-342 Myocardial Infarction, Acute This implies that EV-circITGB1 is involved in dendritic cell maturation and cardiac damage via miR +lncRNA target 35615577 hsa-mir-3200 Carcinoma, Hepatocellular In summary, these findings illuminate some of the molecular mechanisms through which downregulation of HULC induces liver cancer cell ferroptosis by targeting the miR +lncRNA target 35615577 hsa-mir-3200 Thyroid Cancer, Papillary In summary, these findings illuminate some of the molecular mechanisms through which downregulation of HULC induces liver cancer cell ferroptosis by targeting the miR +other 35615532 hsa-mir-139 Carcinoma, Hepatocellular RESULT: SNHG3 was observed to be the most promising upstream lncRNA for the hsa-miR5p/LPCAT1 axis in LIHC. +transcription factor target 35615474 hsa-mir-142 Diabetic Angiopathies The inhibition of miR +lncRNA target 35615401 hsa-mir-25 Lung Neoplasms Collectively, our findings show that upregulated PCAT19 suppresses proliferation yet promotes the apoptosis of LC cells through modulating the miR +circulation_biomarker_diagnosis_ns 35615399 hsa-mir-296 Diabetic Nephropathies In this study, the role of circ_000166/miR-296/SGLT2 in the process of DN-related renal fibrosis was studied by constructing an animal model of DN renal fibrosis via lentiviral transfection, plasmid transfection, and dual-luciferase reporting techniques. We postulate that circ_000166/miR-296/SGLT2 may become a new target in the progression of DN renal fibrosis, and the regulation of this pathway may be a promising strategy for clinical treatment of DN renal fibrosis. +other 35614883 hsa-mir-192 Nephrotic Syndrome Ultimately, in this study, diabetes led to up-regulation of TGF-beta while troxerutin proved to have a protective effect on the kidney by increasing SIP and lowering miR-192 levels. +other 35614883 hsa-mir-192 Diabetic Nephropathies Ultimately, in this study, diabetes led to up-regulation of TGF-beta while troxerutin proved to have a protective effect on the kidney by increasing SIP and lowering miR-192 levels. +genetics_knock down_promote 35614065 hsa-mir-199a Esophageal Squamous Cell Carcinoma The fractionated irradiation-induced irradiation-resistant cell line KYSE150R was subjected to gain- and loss-of function studies to explore the effect of SOX17 and downstream effectors MALAT1, miR-199a, and HIF1alpha on the malignant phenotypes of ESCC. +circulation_biomarker_prognosis_ns 35614030 hsa-mir-92 Respiratory Distress Syndrome, Newborn PURPOSE: To explore the value of the expression of serum miR-92 and miR-122 combined with lung ultrasound score (LUS) in the prognosis of neonatal acute respiratory distress syndrome (ARDS). CONCLUSIONS: The increased expression of serum miR-92 and miR-122 is related to the severity and prognosis of children with ARDS, combined with the LUS score are of value to predict the prognosis of children with ARDS. +circulation_biomarker_prognosis_ns 35614030 hsa-mir-122 Respiratory Distress Syndrome, Newborn PURPOSE: To explore the value of the expression of serum miR-92 and miR-122 combined with lung ultrasound score (LUS) in the prognosis of neonatal acute respiratory distress syndrome (ARDS). CONCLUSIONS: The increased expression of serum miR-92 and miR-122 is related to the severity and prognosis of children with ARDS, combined with the LUS score are of value to predict the prognosis of children with ARDS. +circulation_biomarker_diagnosis_ns 35613957 hsa-mir-21 Carcinoma, Pancreatic Ductal A combined panel of PJ EV-miR-21, EV-miR-25, EV-miR-16, and serum EV-miR-210 and CA19-9 distinguishes cases with PDAC from controls undergoing surveillance with a specificity of 81.5% and sensitivity of 84.2%. +circulation_biomarker_diagnosis_ns 35613957 hsa-mir-25 Carcinoma, Pancreatic Ductal A combined panel of PJ EV-miR-21, EV-miR-25, EV-miR-16, and serum EV-miR-210 and CA19-9 distinguishes cases with PDAC from controls undergoing surveillance with a specificity of 81.5% and sensitivity of 84.2%. +circulation_biomarker_diagnosis_ns 35613957 hsa-mir-210 Carcinoma, Pancreatic Ductal A combined panel of PJ EV-miR-21, EV-miR-25, EV-miR-16, and serum EV-miR-210 and CA19-9 distinguishes cases with PDAC from controls undergoing surveillance with a specificity of 81.5% and sensitivity of 84.2%. +circulation_biomarker_diagnosis_ns 35613957 hsa-mir-16 Carcinoma, Pancreatic Ductal A combined panel of PJ EV-miR-21, EV-miR-25, EV-miR-16, and serum EV-miR-210 and CA19-9 distinguishes cases with PDAC from controls undergoing surveillance with a specificity of 81.5% and sensitivity of 84.2%. +genetics_overexpression_promote 35613309 hsa-mir-200b Pre-Eclampsia Moreover, increased expression of miR-200b-3p was revealed in the placental tissues of preeclampsia patients, and overexpression of miR-200b-3p suppressed cell proliferation and migration but promoted apoptosis of trophoblast cells. +circulation_biomarker_diagnosis_ns 35613088 hsa-mir-125a Diabetes, Gestational Analysis by logistic regression with leave-one-out-cross validation revealed the optimal combination of miRNAs using all the circulating miRNAs (miR-92a-3p, miR +circulation_biomarker_diagnosis_ns 35613088 hsa-mir-92b Diabetes, Gestational Analysis by logistic regression with leave-one-out-cross validation revealed the optimal combination of miRNAs using all the circulating miRNAs (miR-92a-3p, miR +circulation_biomarker_diagnosis_ns 35613088 hsa-mir-100 Diabetes, Gestational Analysis by logistic regression with leave-one-out-cross validation revealed the optimal combination of miRNAs using all the circulating miRNAs (miR-92a-3p, miR +circulation_biomarker_diagnosis_ns 35613088 hsa-mir-92a Diabetes, Gestational Analysis by logistic regression with leave-one-out-cross validation revealed the optimal combination of miRNAs using all the circulating miRNAs (miR-92a-3p, miR +circulation_biomarker_diagnosis_ns 35613088 hsa-mir-192 Diabetes, Gestational Analysis by logistic regression with leave-one-out-cross validation revealed the optimal combination of miRNAs using all the circulating miRNAs (miR-92a-3p, miR +circulation_biomarker_diagnosis_ns 35613088 hsa-mir-122 Diabetes, Gestational Analysis by logistic regression with leave-one-out-cross validation revealed the optimal combination of miRNAs using all the circulating miRNAs (miR-92a-3p, miR +circulation_biomarker_diagnosis_ns 35613088 hsa-mir-451a Diabetes, Gestational Analysis by logistic regression with leave-one-out-cross validation revealed the optimal combination of miRNAs using all the circulating miRNAs (miR-92a-3p, miR +circRNA target 35612554 hsa-mir-149 Squamous Cell Carcinoma of Head and Neck Inhibition of miR-149 can rescue the inhibitory effects of circ_0014359 knock down on OSCC cells. The circ_0014359-miR-149 pathway may be a novel target for developing strategies for the diagnosis and treatment of OSCC. +circulation_biomarker_diagnosis_ns 35612288 hsa-mir-21 Lung Neoplasms As a proof of principle, we measure the level of plasma miRNA-21 in 20 lung cancer patients and 10 healthy participants. +genetics_knock down_promote 35611986 hsa-mir-370 Siderosis Additionally, miR-370 targeting the transferrin receptor protein and upregulated transferrin receptor (TFRC) abolished the effects of overexpressed miR-370 on cell viability and ferroptosis of PDLSCs. +circulation_biomarker_diagnosis_ns 35611880 hsa-mir-181a Femur Head Necrosis The results showed a notable decrease in the serum of miR-181a-5p in methylprednisolone-induced ONFH rats. +other 35611851 hsa-mir-155 Hypertension, Pulmonary miR5p/PYGL pathway was revealed to play a crucial role in PAH by weighted gene co-expression network analysis (WGCNA). +genetics_knock down_promote 35611803 hsa-mir-455 Carcinoma, Non-Small-Cell Lung Knockdown of CRNDE attenuated NSCLC progression via modulation of the miR +lncRNA target 35611785 hsa-mir-495 Asthma CONCLUSION: We concluded that FABP5, CXCL3, suppressor of cytokine signaling 3 (SOCS3), E1A binding protein P300 (EP300), NFATc2, microRNA 495 (miR-495), and miR-30 may play important roles in treating asthma. +circRNA target 35611768 hsa-mir-2355 Myocardial Reperfusion Injury In summary, these results demonstrated circRBMS1 played a protective role in myocardial I/R injury though inhibition of miR +lncRNA target 35611752 hsa-mir-15a Heart Failure Nevertheless, the biological role and function of microRNA (miR)-15a in HF are still unknown. Overall, miR-15a could inhibit LX-2 cell viability and HF pathogenesis by targeting SOX9 in vitro and in vivo. +circRNA target 35611720 hsa-mir-30 Leukemia, Myeloid, Acute CONCLUSION: All these findings revealed that circRNF220 contributed to AML cell development in vitro via upregulating SOX4 expression by targeting miR +lncRNA target 35611706 hsa-mir-181c Breast Neoplasms In ESCC cells and tissues, BCAR4 and microRNA -181c-5p (miR-181c-5p) expression, and phosphorylated signal transducer and activator of transcription (p-STAT3) and COX2 expression were evaluated by real-time reverse transcription PCR (qRT-PCR) and Western blot analysis. In conclusion, BCAR4 promotes ESCC tumorigenesis by targeting the miR-181c-5p/LASP1 axis, which may act as a treatment and diagnosis biomarker for ESCC. +lncRNA target 35611706 hsa-mir-181c Esophageal Squamous Cell Carcinoma In ESCC cells and tissues, BCAR4 and microRNA -181c-5p (miR-181c-5p) expression, and phosphorylated signal transducer and activator of transcription (p-STAT3) and COX2 expression were evaluated by real-time reverse transcription PCR (qRT-PCR) and Western blot analysis. In conclusion, BCAR4 promotes ESCC tumorigenesis by targeting the miR-181c-5p/LASP1 axis, which may act as a treatment and diagnosis biomarker for ESCC. +genetics_overexpression_promote 35611688 hsa-mir-34c Hodgkin Disease Importantly, the number of viable cells in the blood vessels following HLI was increased by miR-34c overexpression. +circulation_biomarker_diagnosis_ns 35611688 hsa-mir-34c Hypoxia-Ischemia, Brain Collectively, our findings show that miR-34c plays a protective role in hypoxia, suggesting a novel therapeutic target for hypoxic and ischemic diseases in the blood vessels. +circulation_biomarker_diagnosis_up 35611688 hsa-mir-34c Ischemia We identified a hypoxia-induced miRNA, miR-34c, that was significantly upregulated in hypoxic human umbilical cord vein endothelial cells (HUVECs) and in murine blood vessels on day 3 of hindlimb ischemia (HLI). +lncRNA target 35611687 hsa-mir-153 Adenocarcinoma of Lung 3p-EVs in the invasion and migration capabilities of LUAD cells and explore its mechanism through in vivo and in vitro experiments. +lncRNA target 35611601 hsa-mir-22 Prostatic Neoplasms In summary, MIR22HG acts as an anticancer gene in prostate cancer via inhibiting cell proliferation and promoting apoptosis by sponging miR +lncRNA target 35611599 hsa-mir-409 Breast Neoplasms All these results indicated that miR-409 regulates breast cancer proliferation and invasion by targeting SATB1 and might be a potential therapeutic target for the treatment of breast cancer. +target gene 35611368 hsa-mir-223 Colorectal Neoplasms Circular RNA circLRCH3 Inhibits Proliferation, Migration, and Invasion of Colorectal Cancer Cells Through miRNA-223/LPP Axis. +genetics_overexpression_suppress 35611198 hsa-mir-1246 Colorectal Neoplasms Furthermore, miR-1182 and miR-1246, which were overexpressed in CRC tissues in GSE41655, GSE49246 and GSE115513, were verified as target miRNAs of circ_0000375 and circ_0011536, respectively, by luciferase reporter assays. The downstream genes of miR-1182 and miR-1246 were enriched in some CRC-associated pathways, such as the Wnt signaling pathway. +genetics_overexpression_suppress 35611198 hsa-mir-1182 Colorectal Neoplasms Furthermore, miR-1182 and miR-1246, which were overexpressed in CRC tissues in GSE41655, GSE49246 and GSE115513, were verified as target miRNAs of circ_0000375 and circ_0011536, respectively, by luciferase reporter assays. The downstream genes of miR-1182 and miR-1246 were enriched in some CRC-associated pathways, such as the Wnt signaling pathway. +other 35610981 hsa-mir-155 COVID-19 Also, the method remains sensitive to fM magnitude lung cancer marker (miRNA-155). +other 35610725 hsa-mir-135a Abortion, Spontaneous RESULTS: Relative to normal pregnancy (NP), villus tissue samples from pregnancies that ended in unexplained sporadic miscarriage (USM) or unexplained recurrent SA (URSA) exhibited miR-135a-5p upregulation. +circRNA target 35610079 hsa-mir-181a Keloid CONCLUSION: Our data showed that circSLC8A1 regulates the miR-181a-5p/HIF1AN axis to restrain HKFs biological functions, confirming that circSLC8A1 might serve as a novel therapeutic target for keloids. +exosome 35609783 hsa-mir-23a Cardiomyopathies Prevention of abnormal adipocyte exosome production, inhibition of miR-23a-3p biogenesis, and treatment with a miR-23a-3p antagonist are novel strategies for treating cardiac fibrosis. +circulation_biomarker_diagnosis_ns 35609481 hsa-mir-21 Breast Neoplasms Under the optimal experimental conditions, the fluorescence system achieved a limit-of-detection of 0.025 amol miR-21 in a 40 muL sample and successfully applied to miR-21 detection in serum samples from breast cancer patients, showing good agreement with the results of RT-PCR, which exhibited great potential in biomedical research and clinical diagnosis. +genetics_overexpression_promote 35609416 hsa-mir-30 Colorectal Neoplasms Conversely, overexpression of SND1 facilitated the malignant phenotypes of CRC cells and restored miR +circulation_biomarker_diagnosis_ns 35609397 hsa-mir-423 Uterine Cervical Neoplasms MiR3p was found to be with low expression in the plasma exosomes of patients with CC. +circRNA target 35609334 hsa-mir-1236 Inflammatory Bowel Diseases Our data confirmed that circ_0001187 facilitated UC progression through miR3p/MYD88 axis, which might be a potential treatment and diagnosis biomarker for UC. +genetics_knock down_promote 35609331 hsa-mir-326 Carcinoma, Non-Small-Cell Lung Taken together, knockdown of lncRNA PCAT6 suppressed the growth of NSCLC cells by inhibiting macrophages M2 polarization via miR-326/KLF1 axis. +other 35609320 hsa-mir-1269 Glioblastoma Overall, miR-1269 is downregulated in GBM and its maturation is regulated by SLC16A1-AS1. +other 35609320 hsa-mir-1296 Glioblastoma MicroRNA-1269 (miR-1296) promotes esophageal cancer. +target gene 35609318 hsa-mir-582 Carcinoma, Hepatocellular MicroRNA-582-3p targeting ribonucleotide reductase regulatory subunit M2 inhibits the tumorigenesis of hepatocellular carcinoma by regulating the Wnt/β-catenin signaling pathway. +circRNA target 35609310 hsa-mir-197 Uterine Cervical Neoplasms CC tumorigenesis was suppressed by OMT via targeting circ_0008460/miR +lncRNA target 35609226 hsa-mir-519d Pulmonary Disease, Chronic Obstructive All four were identified as target genes of hsa-miR-519d-3p, which was significantly down-regulated in COPD patients. The results from this study proposed that regulatory network of hsa-miR-519d-3p/CDKN1A, HIF1A, MXD1, and SOD2 closely associated with the progression of COPD, which provides a theoretical basis to link aging effectors with COPD progression, and may suggest new diagnostic and therapeutic targets of this disease. +lncRNA target 35608718 hsa-mir-1297 Acquired Immunodeficiency Syndrome To explore the role of the miRNA-1297/phospholipase Cbeta1 (PLCbeta1) axis in intestinal barrier injury. miR-1297 could restrain the repair of intestinal barrier injury via negatively regulating PLCbeta1 and its tight junction downstream protein ZO-1 in CCC-HIE-2 cells injured by LPS, which indicated that PLCbeta1 and miR-1297 might be important targets for the repair of intestinal barrier injury. +lncRNA target 35608340 hsa-mir-361 Arthritis, Rheumatoid 5p in both synovial tissues of RA patients and cultured RA-FLS cells. +genetics_overexpression_promote 35608154 hsa-mir-223 Trigeminal Neuralgia 3p overexpression by an intracerebroventricular injection of Lv-miR +other 35608068 hsa-mir-33 Arthritis, Rheumatoid DISCUSSION AND CONCLUSIONS: Our results suggest that EMS may reduce macrophage polarisation to the M1 inflammatory phenotype by downregulating the miRNA-33/NLRP3 pathway in AA rats. +genetics_overexpression_suppress 35608059 hsa-mir-379 Breast Neoplasms Overexpression of miR +lncRNA target 35607960 hsa-mir-632 Rectal Neoplasms Overall, our findings reveal that FEZF1-AS1/miR-632/FAM83A axis plays an oncogenic role in rectal cancer progression, suggesting that it may be a novel therapeutic target for rectal cancer. +lncRNA target 35607443 hsa-mir-532 Colonic Neoplasms The ceRNA axis MIAT/miR3p/STC1 could serve as a promising therapeutic target for colon adenocarcinoma. +circulation_biomarker_prognosis_up 35607440 hsa-mir-208a Myocardial Infarction qRT-PCR assay was carried out to quantify serum miR-208a in the patients and receiver-operating characteristic (ROC) curves for analysing its diagnostic value in AMI patients and its predictive value in clinical efficacy and adverse events in the patients after therapy. +other 35607378 hsa-mir-122 Hearing Disorders Unveiling the mechanism of miR5p in the mediation of forkhead box O3 (FOXO3) in regards to cochlear hair cell damage provides an effective solution for the treatment of ear hearing disorders. +lncRNA target 35607288 hsa-mir-200c Diabetic Retinopathy The objective of this study was to elucidate the underlying molecular mechanisms by which miR-200c-3p regulates the pyroptosis of DR cell. CONCLUSION: The results suggest that miR-200c-3p might be a promising interference target for DR prevention and treatment. +other 35606727 hsa-mir-21 Pancreatic Carcinoma MiR-10b, miR-21, and GPC1 were the most frequently reported RNA and protein for PC diagnosis. +other 35606727 hsa-mir-10b Pancreatic Carcinoma MiR-10b, miR-21, and GPC1 were the most frequently reported RNA and protein for PC diagnosis. +lncRNA target 35606572 hsa-mir-454 Neuroblastoma 3p to up-regulate NEUROD1 expression, deepening our comprehension of lncRNA involved in NB and providing access to the possibility of LINC00839 as a therapeutic target for NB. +transcription factor target 35606547 hsa-mir-122 Aortic Aneurysm, Thoracic In summary, this study demonstrates that miR-122 in the aortic wall inhibits inflammatory responses and matrix remodeling, which is suppressed by deficient fibrillincell interaction and hypoxia in TAA. +other 35606527 hsa-mir-21 Glioblastoma Based on miR-21 and miR-10b expression z-scores, approximately 30% of GBM patients were classified as having the GBM BVZ-responsive subtype. +other 35606527 hsa-mir-10b Glioblastoma Based on miR-21 and miR-10b expression z-scores, approximately 30% of GBM patients were classified as having the GBM BVZ-responsive subtype. +exosome 35606376 hsa-mir-22 ankylosing spondylitis 1 The current study aimed to elucidate the mechanisms regarding extracellular vesicle (EV)-packaged microRNA +circulation_biomarker_diagnosis_up 35606305 hsa-mir-222 Carcinoma, Hepatocellular On the other hand, the mean serum value of microRNA 222-3p was significantly raised in the HCC post DAA therapy group than in the control group (P = 0.007), whereas no statistically significant difference was observed between both groups with HCC and between the group with HCV-related HCC without prior exposure to DAAs and control group. +lncRNA target 35605595 hsa-mir-29a Scleral Diseases CONCLUSION: MiR-29a inhibits the expression of PTEN, MMP-2, and collagen I on scleral fibroblasts, which may provide a basis studies in sclera. +transcription factor target 35605149 hsa-mir-146a Diabetic Retinopathy In summary, miR-146a could inhibit VEGF expression and inflammation in DR. +lncRNA target 35604743 hsa-mir-593 Squamous Cell Carcinoma of Head and Neck In conclusion, appropriate diagnostic biomarkers and therapies for OSCC can be identified by targeting the TUG1/miR +transcription factor target 35604451 hsa-mir-16 Diabetes Mellitus "Destabilizing these inflammatory mRNAs by the miR-16 could reduce inflammation. Cholesterol-tagged miR-16 and its mimic are novel anti-inflammatory molecules that can be specifically targeted to, via through CD36 expressing, ""inflamed"" cells and thus serve as therapeutic candidates to alleviate inflammatory diseases." +genetics_overexpression_promote 35604113 hsa-mir-146a Diabetes Mellitus The results revealed that overexpression of miR-146a promoted the M2 macrophage polarization by suppressing the TLR4/nuclear factor-kappaB (NF-kappaB) axis, so as to enhance wound healing in diabetic ulcers. +genetics_overexpression_promote 35604113 hsa-mir-146 Diabetes Mellitus The results revealed that overexpression of miR-146a promoted the M2 macrophage polarization by suppressing the TLR4/nuclear factor-kappaB (NF-kappaB) axis, so as to enhance wound healing in diabetic ulcers. +lncRNA target 35603999 hsa-mir-155 Non-alcoholic Fatty Liver Disease 5p expression to inhibit STC1 expression, thus inducing hepatic mitochondrial dysfunction and promoting the occurrence and development of NAFLD. +lncRNA target 35603775 hsa-mir-613 Polycystic Ovary Syndrome Therefore, HLA-F-AS1 may inhibit the maturation of miR-613 in PCOS to promote ovarian granulosa cell proliferation and inhibit cell apoptosis. +other 35603556 hsa-mir-3163 Adenocarcinoma of Lung Reverse transcription quantitative polymerase chain reaction (RT-qPCR) was performed to detect the expression of long non-coding (lnc)RNA AFAP1-AS1, the microRNA (miR)-3163, and secreted phosphoprotein 1 (SPP1) in LUAD tissues, or of A549 and H3122 cells. +transcription factor target 35603476 hsa-mir-29b Spinal Cord Injuries After the cells were cultured with EVs without any treatment, uptake of EVs by SCI neurons, miR-29b-3p expression, cell viability, apoptosis, caspase-3, cleaved caspase-3, caspase 9, Bcl-2, PTEN, PI3K, AKT, and p-Akt protein levels, caspase 3 and caspase 9 activities, and inflammatory factors IL-6 and IL-1beta levels were detected by immunofluorescence labeling, RT-qPCR, MTT, flow cytometry, Western blot, caspase 3 and caspase 9 activity detection kits, and ELISA. CONCLUSION: hUC-MSCs-EVs activated the PI3K/AKT pathway by carrying miR-29b-3p into SCI neurons and silencing PTEN, thus reducing neuronal apoptosis. +other 35603405 hsa-mir-218 Osteoarthritis In potential mRNA-miRNA regulatory network, hsa-miR-449a and hsa-miR5p may be involved in the development of OA. +other 35603405 hsa-mir-449a Osteoarthritis In potential mRNA-miRNA regulatory network, hsa-miR-449a and hsa-miR5p may be involved in the development of OA. +transcription factor target 35602576 hsa-mir-585 Ovarian Neoplasms 3p may serve as a potential biomarker and therapeutic target for OC. +circulation_biomarker_diagnosis_up 35602517 hsa-mir-4745 sporatic amyotrophic lateral sclerosis Among them, the analysis of expression levels of the couple of blood miR-193b/miR +circulation_biomarker_diagnosis_up 35602517 hsa-mir-193b sporatic amyotrophic lateral sclerosis Among them, the analysis of expression levels of the couple of blood miR-193b/miR +circulation_biomarker_diagnosis_up 35602517 hsa-mir-193b-1 sporatic amyotrophic lateral sclerosis Among them, the analysis of expression levels of the couple of blood miR-193b/miR +circulation_biomarker_diagnosis_ns 35602301 hsa-mir-937 Colorectal Neoplasms To assess the expression levels and predictive usefulness of plasma exosomal hsa-miR-3937 in CRC, we performed RT-qPCR to identify hsa-miR-3937 levels in all samples. +circRNA target 35602296 hsa-mir-583 Colorectal Neoplasms CONCLUSION: We demonstrated that hsa_circ_0001955 facilitated CRC progression via miR-583/FGF21 axis, suggesting that hsa_circ_0001955 may provide a novel insight for therapy of CRC. +lncRNA target 35602292 hsa-mir-128 Nasopharyngeal Carcinoma 3p, which might serve as a potential therapy target of NPC. +genetics_GWAS 35602094 hsa-mir-299a Spinal Cord Injuries The PHLPP1 overexpression of AMPK inhibition with either genetic or pharmacologic methods dramatically abolished the miR-299a-5p agomir-mediated protective effects against SCI. +genetics_overexpression_promote 35601153 hsa-mir-708 Laryngeal Neoplasms 5p overexpression and MALAT1 suppression had synergistic inhibitory effects on the malignant phenotypes of laryngocarcinoma cells and the expression of BRD4, YAP1, and EMT. +genetics_GWAS 35601073 hsa-mir-196a COVID-19 The present study investigated the association of the ACE2 rs4343 G>A and miR-196a2 rs11614913 C>T gene polymorphisms with severity and mortality of COVID-19 using amplification refractory mutation system PCR in 117 COVID-19 patients and 103 healthy controls from three regions of Saudi Arabia. The results also showed that the CT genotype and T allele of the miR-196a2 rs11614913 C>T were associated with decreased risk to COVID-19 with OR=0.76, P=0.006 and OR=0.54, P=0.005, respectively. +other 35601073 hsa-mir-196 COVID-19 Gene variations of ACE2 and microRNA (miR)-196 are associated with viral infection and other diseases. +circRNA target 35600959 hsa-mir-145 Adenocarcinoma of Lung Circ_0001998 regulates the proliferation, invasion, and apoptosis of LUAD via sponging miR-145. +lncRNA target 35600767 hsa-mir-134 Neurotic Disorders CONCLUSION: These data provide strong evidence that Rb1 rescued CUMS-induced depression-like effects by modulating hippocampal synaptic plasticity via the miRmediated BDNF signaling pathway. +circulation_biomarker_diagnosis_ns 35600587 hsa-mir-6891 Intrahepatic Cholestasis of Pregnancy 5p in maternal serum exosomes were significantly lower in ICP patients compared to controls; the diagnostic accuracy of hsa-miR-4271, hsa-miR-1275, and hsa-miR +circulation_biomarker_diagnosis_ns 35600587 hsa-mir-4271 Intrahepatic Cholestasis of Pregnancy 5p in maternal serum exosomes were significantly lower in ICP patients compared to controls; the diagnostic accuracy of hsa-miR-4271, hsa-miR-1275, and hsa-miR +circulation_biomarker_diagnosis_ns 35600587 hsa-mir-1275 Intrahepatic Cholestasis of Pregnancy 5p in maternal serum exosomes were significantly lower in ICP patients compared to controls; the diagnostic accuracy of hsa-miR-4271, hsa-miR-1275, and hsa-miR +genetics_overexpression_suppress 35600383 hsa-mir-195 Adenocarcinoma of Lung 5p, and overexpression of miRNA +circulation_biomarker_diagnosis_ns 35600346 hsa-mir-371a Seminoma Serum levels of microRNA-371a-3p (M371) involve high specificity and sensitivity for the primary diagnosis of seminoma. +genetics_knock down_promote 35600345 hsa-mir-133a Colorectal Neoplasms RP9P knockdown decreased FOXQ1 expression levels in CRC cells by directly targeting miR-133a-3p via a sponge mechanism. +other 35600155 hsa-mir-9 Angelman Syndrome Circ_0090231 could attenuate ox-LDL-mediated HUVEC damage by the miR5p/TXNIP axis, providing a promising therapeutic strategy for AS treatment. +genetics_knock down_promote 35600150 hsa-mir-22 Sepsis 3p/CXCL12/NF-kappaB signaling pathway, suggesting that NEAT1 knockdown might be a potential pathway for alleviating sepsis-induced AKI. +genetics_knock down_promote 35600150 hsa-mir-22 Acute Kidney Injury 3p/CXCL12/NF-kappaB signaling pathway, suggesting that NEAT1 knockdown might be a potential pathway for alleviating sepsis-induced AKI. +other 35600044 hsa-mir-9 Carcinoma, Hepatocellular 5p-mediated downregulation of TSPAN9 was associated with poor HCC prognosis, immune-related signaling pathway, and tumor immune infiltration. +other 35599631 hsa-mir-19a Colorectal Neoplasms Thus, we proposed a novel mechanism of ferroptosis mediated by miR-19a in CRC cells, which could give rise to a new strategy for the therapy of CRC. +transcription factor target 35599617 hsa-mir-663 Plaque, Atherosclerotic This study probed into the function of miR-663 in AS. CONCLUSION: miR-663 targeted HMGA2 to inhibit VSMC proliferation and AS development, which may offer insights into AS treatment. +transcription factor target 35599617 hsa-mir-663 Atherosclerosis This study probed into the function of miR-663 in AS. CONCLUSION: miR-663 targeted HMGA2 to inhibit VSMC proliferation and AS development, which may offer insights into AS treatment. +transcription factor target 35599576 hsa-mir-27b Sepsis Therefore, this study revealed that Chrysophanol guarded against sepsis-mediated acute myocardial injury through dampening inflammation and apoptosis via the miR-27b-3p-PPARG axis, adding to the references for treating sepsis-AMI. +transcription factor target 35599576 hsa-mir-27b Myocardial Infarction, Acute Therefore, this study revealed that Chrysophanol guarded against sepsis-mediated acute myocardial injury through dampening inflammation and apoptosis via the miR-27b-3p-PPARG axis, adding to the references for treating sepsis-AMI. +lncRNA target 35599572 hsa-mir-524 Diabetic Retinopathy Taken together, suppressing TUG1 impairs vascular function in diabetic retinas via controlling miR5p and FGFR2, suggesting a possible therapy method for DR. +genetics_overexpression_promote 35599447 hsa-mir-485 Carcinoma, Non-Small-Cell Lung RRM2 overexpression partly reversed miR-200c-3p or miR +genetics_overexpression_promote 35599447 hsa-mir-200c Carcinoma, Non-Small-Cell Lung RRM2 overexpression partly reversed miR-200c-3p or miR +circulation_biomarker_diagnosis_up 35599383 hsa-mir-21 Colorectal Neoplasms The present nano-genosensor shows superior performance for miR-21 in human serum samples and demonstrates a potential application for the diagnosis of early stage colorectal cancer. +lncRNA target 35599309 hsa-mir-4428 Carcinoma, Non-Small-Cell Lung Finally, in vitro and in vivo assays jointly validated that LINC01806 exerted its function in NSCLC development via miR-4428/NOTCH2 pathway. CONCLUSION: LINC01806 enhanced NOTCH2 expression to stimulate Notch signaling via sponging miR-4428, thereby facilitating NSCLC progression, which provided a novel mechanism for NSCLC therapeutic approaches. +circulation_biomarker_diagnosis_ns 35599275 hsa-mir-4467 Schizophrenia 5p and miR-4467 hold promise in blood diagnosis for SCZ, and miR +circulation_biomarker_diagnosis_ns 35599275 hsa-mir-9 Schizophrenia 5p and miR-4467 hold promise in blood diagnosis for SCZ, and miR +other 35598655 hsa-mir-200a Alzheimer Disease Although the idea of sponging of miRNAs by lncRNAs in other pathologies is gradually gaining credibility, this novel MALAT1- miR-200a/26a/26b - EPHA2 regulation mechanism in the context of AD pathophysiology promises to become a significant strategy in controlling the disease. +circulation_biomarker_diagnosis_up 35598633 hsa-mir-124 Lupus Erythematosus, Systemic 3p was an independent predictor for SLE, and the plasma miR +circulation_biomarker_diagnosis_up 35598633 hsa-mir-377 Lupus Erythematosus, Systemic 3p was an independent predictor for SLE, and the plasma miR +exosome 35598413 hsa-mir-455 Hippocampal Neuronal Injury CONCLUSION: MSCs-derived exosomal miR +transcription factor target 35598381 hsa-mir-9 Glioma GSC-derives EVs could promote GBM growth and migration Moreover, inhibition of miR-9 in GSCs showed the reverse anti-tumor effects through secreted EVs. +lncRNA target 35598218 hsa-mir-183 Thyroid Cancer, Papillary Collectively, our findings suggest that circ_FAM53B affects PTC cell biological behaviors via the miR5p-CCDC6 axis. +other 35597927 hsa-mir-182 Hyperphosphatemia RNA-seq analysis of HP-EC-EVs illustrated that one known miR (hsa-miR-3182) was statistically up-regulated and twelve miRs were significantly down-regulated, which was verified by qRT-PCR. +genetics_knock down_promote 35597500 hsa-mir-1178 Breast Neoplasms The inhibition of miR-1178 and overexpression of PRMT7 reversed the effect of circ_0039960 knockdown on BC cell growth and Warburg effect. +lncRNA target 35597494 hsa-mir-145 Atherosclerosis 5p and then activating autophagy in HAVSMCs through the AMPK/mTOR/ULK1 signalling pathway to affect the AS progress. +genetics_knock down_promote 35597301 hsa-mir-136 Carcinoma, Renal Cell 5p was increased, and MAT2B expression was decreased after CYTOR knockdown, thereby inhibiting the development of RCC. +genetics_overexpression_promote 35597125 hsa-mir-4742 Stomach Neoplasms 5p expression, whereas overexpression of miR +transcription factor target 35596947 hsa-mir-44438 Parkinson Disease The miRNA, novel_miR_44438, was significantly increased in the PD group, which promoted alpha-syn accumulation and neuronal degeneration in a dose-dependent manner. INTERPRETATION: Novel_miR_44438 in PD-derived L1CAM-purified EVs inhibits the alpha-syn efflux from neurons thereby promoting the pathological accumulation and aggregation of alpha-syn. +other 35596257 hsa-let-7a Pre-Eclampsia CONCLUSIONS: High let-7a and IFN-gamma expressions were correlated with clinical features, and could be used as biomarkers for treatment and poor prognosis of PECsf. +other 35596173 hsa-mir-15a Diabetes Mellitus, Type 2 METHODS: We aimed to investigate the influence of hypoglycaemia on several diabetes-related and platelet-related miRNAs selected based on bioinformatic analysis and literature search, including hsa-miR-16, hsa-miR-34a, hsa-miR2, hsa-miR-15a, hsa-miR-15b, hsa-miR-106a, miR-223, miR-126. +other 35596173 hsa-mir-223 Diabetes Mellitus, Type 2 METHODS: We aimed to investigate the influence of hypoglycaemia on several diabetes-related and platelet-related miRNAs selected based on bioinformatic analysis and literature search, including hsa-miR-16, hsa-miR-34a, hsa-miR2, hsa-miR-15a, hsa-miR-15b, hsa-miR-106a, miR-223, miR-126. +other 35596173 hsa-mir-15b Diabetes Mellitus, Type 2 METHODS: We aimed to investigate the influence of hypoglycaemia on several diabetes-related and platelet-related miRNAs selected based on bioinformatic analysis and literature search, including hsa-miR-16, hsa-miR-34a, hsa-miR2, hsa-miR-15a, hsa-miR-15b, hsa-miR-106a, miR-223, miR-126. +other 35596173 hsa-mir-34a Diabetes Mellitus, Type 2 METHODS: We aimed to investigate the influence of hypoglycaemia on several diabetes-related and platelet-related miRNAs selected based on bioinformatic analysis and literature search, including hsa-miR-16, hsa-miR-34a, hsa-miR2, hsa-miR-15a, hsa-miR-15b, hsa-miR-106a, miR-223, miR-126. +other 35596173 hsa-mir-16 Diabetes Mellitus, Type 2 METHODS: We aimed to investigate the influence of hypoglycaemia on several diabetes-related and platelet-related miRNAs selected based on bioinformatic analysis and literature search, including hsa-miR-16, hsa-miR-34a, hsa-miR2, hsa-miR-15a, hsa-miR-15b, hsa-miR-106a, miR-223, miR-126. +other 35596173 hsa-mir-126 Diabetes Mellitus, Type 2 METHODS: We aimed to investigate the influence of hypoglycaemia on several diabetes-related and platelet-related miRNAs selected based on bioinformatic analysis and literature search, including hsa-miR-16, hsa-miR-34a, hsa-miR2, hsa-miR-15a, hsa-miR-15b, hsa-miR-106a, miR-223, miR-126. +other 35596173 hsa-mir-106a Diabetes Mellitus, Type 2 METHODS: We aimed to investigate the influence of hypoglycaemia on several diabetes-related and platelet-related miRNAs selected based on bioinformatic analysis and literature search, including hsa-miR-16, hsa-miR-34a, hsa-miR2, hsa-miR-15a, hsa-miR-15b, hsa-miR-106a, miR-223, miR-126. +other 35596173 hsa-mir-129-2 Diabetes Mellitus, Type 2 METHODS: We aimed to investigate the influence of hypoglycaemia on several diabetes-related and platelet-related miRNAs selected based on bioinformatic analysis and literature search, including hsa-miR-16, hsa-miR-34a, hsa-miR2, hsa-miR-15a, hsa-miR-15b, hsa-miR-106a, miR-223, miR-126. +other 35596172 hsa-mir-675 Colorectal Neoplasms This study aims to investigate the role of the hypoxia-induced miR5p in 5-Fluorouracil (5-FU) resistance on colorectal cancer (CRC) cells. +virus_miRNA 35596131 hcmv-mir-US33 Acute Aortic Dissection HCMV-miR-US33-5p promotes apoptosis of aortic vascular smooth muscle cells by targeting EPAS1/SLC3A2 pathway +circulation_biomarker_diagnosis_ns 35596051 hsa-mir-642 Pancreatic Carcinoma METHODS AND RESULTS: In the current study, we assessed expression levels of miR-8073 and miR-642 in the circulation of 50 patients with pancreatic cancer and 50 controls. Plasma levels of miR-8073 and miR-642 were significantly higher in patients with pancreatic cancer compared with controls (P value < 0.0001 and P value = 0.0068, respectively). +genetics_overexpression_suppress 35595956 hsa-mir-133 Arthritis, Rheumatoid Overexpression of miR-133 reduced cell viability and migration of RA FLS, with decreased levels of FSCN1, EGFR, and MET. +other 35595718 hsa-mir-200 Colorectal Neoplasms This was driven by miR-200 (miR-200a/b/c, -141), which was enriched in epithelial CRC EVs and transferred to recipient fibroblasts. Supporting these findings, there was a strong negative correlation between miR-200 and myofibroblastic markers in a cohort of CRC patients in the TCGA dataset. +other 35595039 hsa-mir-223 Inflammatory Bowel Diseases In conclusion, our study provided a novel protective impact for MFE against UC, in which miRNA-223 and TNFalpha/NFkappaB/NLRP3 pathway are involved. +other 35594893 C19MC cluster Carcinoma, Embryonal METHODS: The authors evaluated 4 patients with ETMR at their institution who showed varied clinical features and also conducted clinical characterization and prognostic analysis of previously reported cases of the ETMR-presenting locus 19q13.42 with a chromosome 19 microRNA cluster (C19MC) amplification, which is known to be a diagnostic hallmark of the tumor. +lncRNA target 35594842 hsa-mir-10b Glioblastoma (2022) demonstrates how two long non-coding RNAs (lncRNAs) link a distal enhancer to the HOXD3/D4/miR-10b gene promoter, leading to transcriptional activation of the therapeutic target miR-10b in glioblastoma multiforme. +circulation_biomarker_diagnosis_up 35594307 hsa-mir-199a Acquired Immunodeficiency Syndrome Our findings suggest that even though ART uptake and viral suppression might help in maintaining miR3181 and miR199a levels in the placenta of women with HIV at comparative levels to those of their HIV negative counterparts, the significantly higher levels of miR-199a in the plasma of women with HIV compared to the placenta might highlight lurking systemic dangers and requires further investigation. +circulation_biomarker_diagnosis_ns 35594307 hsa-mir-3181 Acquired Immunodeficiency Syndrome There was no significant difference in the levels of miR-3181 (p>0.05) in the placenta and plasma amongst HIV-infected and HIV uninfected women. +other 35593591 hsa-mir-619 Carcinoma, Squamous Cell, Cutaneous Circ_TNFRSF21 and ROCK2 were upregulated in cSCC tissue, while miR5p was downregulated. +transcription factor target 35593587 hsa-mir-181b Cardiovascular Diseases Collectively, this study unveils an important role of miR-181b in regulating vascular endothelial aging via an MAP3K3-MAPK signaling pathway, providing new potential therapeutic targets for antiaging therapy in CVD. +tissue_expression_ns 35593504 hsa-mir-382 Pneumonia LINC00707 deficiency could relieve LPS-triggered WI-38 cell damage by regulating the miR5p/NKAP axis, providing a new therapeutic strategy for IP treatment. +other 35593364 hsa-mir-124 Tetralogy of Fallot CONCLUSION: Hsa-mir-16 and hsa-mir-124 are the key miRNAs of TOF, which mainly regulate the expression of NT5DC1, ECHDC1, HSDL2, FCHO2, and ACAA2 involved in the conversion of ATP in the mitochondria and the metabolic rate of fatty acids (FA). +other 35593364 hsa-mir-16 Tetralogy of Fallot CONCLUSION: Hsa-mir-16 and hsa-mir-124 are the key miRNAs of TOF, which mainly regulate the expression of NT5DC1, ECHDC1, HSDL2, FCHO2, and ACAA2 involved in the conversion of ATP in the mitochondria and the metabolic rate of fatty acids (FA). +other 35593324 hsa-mir-21 Osteoporosis BMD, BALP, BGP, and miR-21 levels in OVX rats were decreased. +lncRNA target 35593126 hsa-mir-6838 Nasopharyngeal Carcinoma CONCLUSION: CircKIAA0368 upregulates HOXA10 expression via miR +transcription factor target 35593122 hsa-mir-744 Osteosarcoma 5p is a negative regulator of TGFB1 and suppresses OS progression and metastasis via the p38 MAPK signaling pathway. +lncRNA target 35592920 hsa-mir-103 Muscular Atrophy Mechanistically, SYISL increases the expression levels of the muscle atrophy genes forkhead box protein O3a (FoxO3a), muscle ring finger 1 (MuRF1), and muscle atrophy-related F-box (Atrogin-1) via sponging of miR-23a-3p/miR +lncRNA target 35592920 hsa-mir-205 Muscular Atrophy Mechanistically, SYISL increases the expression levels of the muscle atrophy genes forkhead box protein O3a (FoxO3a), muscle ring finger 1 (MuRF1), and muscle atrophy-related F-box (Atrogin-1) via sponging of miR-23a-3p/miR +lncRNA target 35592920 hsa-mir-23a Muscular Atrophy Mechanistically, SYISL increases the expression levels of the muscle atrophy genes forkhead box protein O3a (FoxO3a), muscle ring finger 1 (MuRF1), and muscle atrophy-related F-box (Atrogin-1) via sponging of miR-23a-3p/miR +other 35592680 hsa-mir-4435-2 Adenocarcinoma of Lung Meanwhile, a potential ceRNA network was constructed to identify the lncRNA-MIR4435-2HG/miR-125a-5p/SGO1 regulatory axis in LUAD. +other 35592680 hsa-mir-125a Adenocarcinoma of Lung Meanwhile, a potential ceRNA network was constructed to identify the lncRNA-MIR4435-2HG/miR-125a-5p/SGO1 regulatory axis in LUAD. +other 35592674 hsa-mir-20b Ovarian Neoplasms In our study, ceRNA networks including miR-320b and miR-320d probably provided novel insights for platinum resistance in ovarian cancer patients. +other 35592674 hsa-mir-320d Ovarian Neoplasms In our study, ceRNA networks including miR-320b and miR-320d probably provided novel insights for platinum resistance in ovarian cancer patients. +lncRNA target 35592615 hsa-mir-124 Incontinentia Pigmenti Moreover, inhibiting miR +other 35592536 hsa-mir-361 Uterine Cervical Neoplasms 5p/TNF regulatory axis, which may play a vital role in the progression of cervical cancer. +transcription factor target 35592504 hsa-mir-23b Alzheimer Disease In the present study, we investigated the potential therapeutic effects and mechanisms of miR-23b-3p in AD. Collectively, our findings strongly support the hypothesis that miR-23b-3p plays a neuroprotective role in AD, thereby identifying miR-23b-3p as a promising therapeutic target for AD. +lncRNA target 35592503 hsa-mir-145a Myocardial Infarction In summary, circERBB2IP can promote angiogenesis after myocardial infarction through the miR-145a-5p/Smad5 axis. +target gene 35592388 hsa-mir-140 Osteosarcoma LncRNA CBR3-AS1 promotes osteosarcoma progression through the network of miR-140-5p/DDX54-NUCKS1-mTOR signaling pathway. +lncRNA target 35592246 hsa-mir-545 Carcinoma, Hepatocellular Collectively, our data revealed that circFGGY inhibits the proliferation and invasion of HCC cells by sponging miR3p and promote the expression of Smad7, indicating that circFGGY functions as a tumor suppressor and could be a prognostic biomarker for HCC. +other 35592126 hsa-mir-4739 Stomach Neoplasms The expression level of miR-4739 has certain diagnostic value for patients with GC, and the prognosis of patients in LE group was worse than that in HE group. +other 35592108 hsa-mir-506 Stomach Neoplasms LINC01232 Promotes Metastasis and EMT by Regulating miR-506-5p/PAK1 Axis in Gastric Cancer. +target gene 35591840 hsa-mir-145 Stomach Neoplasms 5,7,2,5-tetrahydroxy-8,6-dimethoxyflavone up-regulates miR-145 expression and inhibits proliferation of gastric cancer cells. +lncRNA target 35591837 hsa-mir-485 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: LINC01296 promote the cell cycle, proliferation, migration and invasion, and inhibit apoptosis of OSCC cells through activating the MAPK/ERK signaling pathway via sponging miR +lncRNA target 35591820 hsa-mir-125b Polycystic Ovary Syndrome CONCLUSIONS: Since miR-125b controls the proliferation rate of granulosa cells in polycystic ovaries, it might be addressed as a potential therapeutic target for PCOS patients. +genetics_overexpression_promote 35591810 hsa-mir-221 Depression 3p overexpression or Gab1 downregulation reversed the role of silencing METTL3 in CUMS rats. +other 35590240 hsa-mir-214 Liver Neoplasms 5p may be potential gene signatures related to liver cancer hypoxia. +other 35590240 hsa-mir-296 Liver Neoplasms 5p may be potential gene signatures related to liver cancer hypoxia. +other 35590240 hsa-mir-483 Liver Neoplasms 5p may be potential gene signatures related to liver cancer hypoxia. +other 35590240 hsa-mir-4739 Liver Neoplasms 5p may be potential gene signatures related to liver cancer hypoxia. +genetics_overexpression_promote 35590122 hsa-mir-6511b Colorectal Neoplasms In vitro, overexpression of miR-6511b-5p inhibited metastasis by decreasing CD44 expression via directly targeting BRG1 in colorectal cancer. +circulation_biomarker_diagnosis_up 35590121 hsa-mir-27a Obesity RESULTS: The study results revealed that miR-27a was upregulated in the plasma of MetS group compared to the healthy controls, while miR-320a was downregulated (p FOXA2-->CNTF signaling axis. +exosome 35589002 hsa-mir-1290 Breast Neoplasms Collectively, our findings demonstrate, for the first time, that breast cancer EV-derived miR-1290 and miR-1246 activate astrocytes in the brain metastatic microenvironment and that EV-derived miR-1290 promotes progression of brain metastases through the novel EV-miR>FOXA2-->CNTF signaling axis. +exosome 35589002 hsa-mir-1246 Brain Neoplasms Collectively, our findings demonstrate, for the first time, that breast cancer EV-derived miR-1290 and miR-1246 activate astrocytes in the brain metastatic microenvironment and that EV-derived miR-1290 promotes progression of brain metastases through the novel EV-miR>FOXA2-->CNTF signaling axis. +exosome 35589002 hsa-mir-1246 Breast Neoplasms Collectively, our findings demonstrate, for the first time, that breast cancer EV-derived miR-1290 and miR-1246 activate astrocytes in the brain metastatic microenvironment and that EV-derived miR-1290 promotes progression of brain metastases through the novel EV-miR>FOXA2-->CNTF signaling axis. +circulation_biomarker_diagnosis_up 35588895 hsa-mir-223 Venous Thrombosis RESULTS: The levels of 22 circulating plasma miRNAs (12 up-regulated, 10 down-regulated) were significantly changed in patients with DVT before and after endovascular interventions, especially miR-125a-5p (up-regulation) and miR +circulation_biomarker_diagnosis_up 35588895 hsa-mir-125a Venous Thrombosis RESULTS: The levels of 22 circulating plasma miRNAs (12 up-regulated, 10 down-regulated) were significantly changed in patients with DVT before and after endovascular interventions, especially miR-125a-5p (up-regulation) and miR +circulation_biomarker_diagnosis_ns 35588772 hsa-mir-146a Fetal Alcohol Spectrum Disorders Our findings suggested that certain phthalates exposure was related to plasma miRNAs alterations in a dose-response manner and miR-146a might partly mediate phthalate-associated ABI reduction. +circulation_biomarker_diagnosis_down 35588695 hsa-mir-142 Acute Lung Injury Collectively, serum-derived EVs-loaded miR5p downregulated PTEN and activated PI3K/Akt to inhibit ALI in sepsis following RIPC, thus highlighting potential therapeutic molecular targets against ALI in sepsis. +genetics_overexpression_promote 35588441 hsa-mir-223 Carcinoma, Non-Small-Cell Lung 3p inhibition or PTN overexpression might reverse the inhibitory effects of PITPNA-AS1 suppression on LUSC progression, as demonstrated by rescue experiments. +lncRNA target 35588255 hsa-mir-135b Pre-Eclampsia Therefore, miR-135b-5p may regulate trophoblast function by targeting PIK3R2 in PE and could serve as a novel therapeutic target for PE. +lncRNA target 35587844 hsa-mir-195 Colorectal Neoplasms 5p could be used as a tumor suppressor in colorectal cancer (CRC). +lncRNA target 35587748 hsa-mir-128 Colorectal Neoplasms Altogether, our results showed that LINC00467 contributes to CRC progression and angiogenesis via the miR +other 35587747 hsa-mir-203a Endometriosis It is also suggested that miR-203a-3p, ABL1, and TP63 might be candidate factors for the pathogenesis of endometriosis and suggesting its therapeutic potential in endometriosis. +circulation_biomarker_diagnosis_up 35587745 hsa-mir-20a Fibromyalgia METHODS: The included patients were subjected to detailed history taking, assessment of severity of fibromyalgia symptoms using the Fibromyalgia Impact Questionnaire Revised (FIQR), assessment of pain intensity using the Neuropathic Pain Symptom Inventory (NPSI), measurement of the serum level of miR-320a in addition to of measurement peak latencies and amplitudes of middle latency SSEPs. +lncRNA target 35587661 hsa-mir-100 Arthritis, Temporomandibular 5p) on mammalian target (mTOR) of rapamycin in temporomandibular arthritis. +genetics_overexpression_promote 35587154 hsa-mir-644 Stomach Neoplasms Overexpression of circPFKP enhances the expression of ADAMTSL5 by decreasing the expression of miR-644 to suppress the growth of xenograft GC tumors in vivo and in vitro. In conclusion, the circPFKP/miR-644/ADAMTSL5 regulatory pathway inhibited the malignant progression of GC. +lncRNA target 35587058 hsa-mir-572 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: MiR-572 is closely linked to metastasis and prognosis in NSCLC patients, and it promotes the malignant development of NSCLC via targeting KLF2. +circulation_biomarker_diagnosis_up 35586674 hsa-mir-155 Osteoarthritis, Knee Lysholm knee joint score scale and osteoarthritis index (WOMAC) scale of Western Ontario and McMaster University were used to evaluate the knee joint function of the two groups, and the levels of interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), serum superoxide dismutase (SOD), serum malondialdehyde (MDA), serum miR-155, and NLRP3 were detected in the two groups, and the comprehensive quality of life assessment questionnaire-74 was used, and the adverse reactions were compared between the two groups. +other 35586205 hsa-mir-205 Liver Neoplasms DNAJA1 Stabilizes EF1A1 to Promote Cell Proliferation and Metastasis of Liver Cancer Mediated by miR-205-5p. +other 35586071 hsa-mir-25 Tuberculosis This study demonstrates that the role of miR-25 during Mtb infection contributes to a better understanding of the pathogenesis of tuberculosis (TB). +lncRNA target 35586052 hsa-mir-21 Corneal Neovascularization Collectively, our results suggested that targeting HMGB1-NFkappab axis and miR-21 by GLY could introduce a therapeutic approach to counter CNV. +transcription factor target 35585990 hsa-mir-382 Fibrosis, Renal However, whether miR-382 is implicated in macrophage activation in AA-induced kidney fibrosis remains elusive. Taken together, our data suggest that miR-382 is a critical mediator in M2-like macrophage polarization and can be a promising therapeutic target for kidney fibrosis. +lncRNA target 35585935 hsa-mir-222 Melanoma In addition, inhibition of miR +other 35585886 hsa-mir-106a Carcinoma, Hepatocellular Moreover, miR3p and miR-106a-5p significantly increased the ROS level and stagnated cell cycle at G2/M in HCC; the results were more obvious in cells after ionizing radiation (IR). +other 35585886 hsa-mir-210 Carcinoma, Hepatocellular Moreover, miR3p and miR-106a-5p significantly increased the ROS level and stagnated cell cycle at G2/M in HCC; the results were more obvious in cells after ionizing radiation (IR). +other 35585716 hsa-mir-877 Adenocarcinoma of Lung Hsa-miR-103b, hsa-miR-29c-5p, and hsa-miR5p may be used as diagnostic biomarkers for early LUAD. +other 35585716 hsa-mir-29c Adenocarcinoma of Lung Hsa-miR-103b, hsa-miR-29c-5p, and hsa-miR5p may be used as diagnostic biomarkers for early LUAD. +other 35585716 hsa-mir-103b Adenocarcinoma of Lung Hsa-miR-103b, hsa-miR-29c-5p, and hsa-miR5p may be used as diagnostic biomarkers for early LUAD. +exosome 35585044 hsa-mir-342 Liver Cirrhosis Altogether, our study proved that silence of NEAT1 in the macrophage exosomes exerted protective roles against HF through the miR-342/Sp1/TGF-beta1/Smad signaling pathway, suggesting a potential therapeutic target in HF treatment. +lncRNA target 35584745 hsa-mir-27a Reperfusion Injury, Cerebral Ischemia Furthermore, miR-27a-3p mimic could relieve cerebral infarct and neurologic deficit after CIR. Taken together, our results suggest that miR-27a-3p protects against CIR by relieving inflammation, neuronal damage, and neurologic deficit via regulating LITAF and the TLR4/NF-kappaB pathway. +lncRNA target 35584745 hsa-mir-27a Inflammation Furthermore, miR-27a-3p mimic could relieve cerebral infarct and neurologic deficit after CIR. Taken together, our results suggest that miR-27a-3p protects against CIR by relieving inflammation, neuronal damage, and neurologic deficit via regulating LITAF and the TLR4/NF-kappaB pathway. +other 35583533 hsa-mir-421 Stomach Neoplasms These results indicate that miRNA-421 has the highest diagnostic accuracy, followed by miR-223, miRNA-21, and miRNA-106 among the 4 microRNAs in GC. CONCLUSIONS: miR-21, miR-106, miR-421, and miR-223 have good diagnostic efficacy, especially miR-421, could be used as auxiliary diagnostic indicator for GC. +other 35583533 hsa-mir-223 Stomach Neoplasms These results indicate that miRNA-421 has the highest diagnostic accuracy, followed by miR-223, miRNA-21, and miRNA-106 among the 4 microRNAs in GC. CONCLUSIONS: miR-21, miR-106, miR-421, and miR-223 have good diagnostic efficacy, especially miR-421, could be used as auxiliary diagnostic indicator for GC. +other 35583533 hsa-mir-21 Stomach Neoplasms These results indicate that miRNA-421 has the highest diagnostic accuracy, followed by miR-223, miRNA-21, and miRNA-106 among the 4 microRNAs in GC. CONCLUSIONS: miR-21, miR-106, miR-421, and miR-223 have good diagnostic efficacy, especially miR-421, could be used as auxiliary diagnostic indicator for GC. +other 35583533 hsa-mir-106 Stomach Neoplasms These results indicate that miRNA-421 has the highest diagnostic accuracy, followed by miR-223, miRNA-21, and miRNA-106 among the 4 microRNAs in GC. CONCLUSIONS: miR-21, miR-106, miR-421, and miR-223 have good diagnostic efficacy, especially miR-421, could be used as auxiliary diagnostic indicator for GC. +other 35583104 hsa-mir-515 Allograft Rejection, Antibody-Mediated 3p and miR-29a-3p were downregulated. +other 35583104 hsa-mir-604 Allograft Rejection, Antibody-Mediated 3p and miR-29a-3p were downregulated. +other 35583104 hsa-let-7d Allograft Rejection, Antibody-Mediated 3p and miR-29a-3p were downregulated. +other 35583104 hsa-mir-29a Allograft Rejection, Antibody-Mediated 3p and miR-29a-3p were downregulated. +other 35583104 hsa-mir-590 Allograft Rejection, Antibody-Mediated 3p and miR-29a-3p were downregulated. +other 35583104 hsa-mir-24 Allograft Rejection, Antibody-Mediated 3p and miR-29a-3p were downregulated. +genetics_overexpression_promote 35583065 hsa-mir-335 Triple Negative Breast Neoplasms Overexpression of miR +lncRNA target 35583006 hsa-mir-223 Pulmonary Disease, Chronic Obstructive The present study concluded that lncRNA GAS5 promoted pyroptosis in COPD by targeting the miR2233p/NLRP3 axis, implying that GAS5 could be a potential target for COPD. +lncRNA target 35583000 hsa-mir-142 Neuralgia In summary, the present study demonstrated that SNHG5 silencing could alleviate the neuropathic pain induced by chronic constriction injury via sponging miR1425p and regulating the expression of CAMK2A. +lncRNA target 35582879 hsa-mir-206 Hepatitis C In conclusion, miR-206 could inhibit HCV proliferation through depressing ACC1 lipogenesis pathway and decreasing the lipid droplet numbers. +genetics_knock down_promote 35582765 hsa-mir-378a Inflammatory Bowel Diseases After loss- and gain-of-function assays, the regulatory role of MSCs-derived EVs loaded with manipulated miR-378a-3p in IBD in relation to GATA2/AQP4/PPAR-alpha were explored. +genetics_overexpression_promote 35582664 hsa-mir-15b Diabetic Nephropathies miR-15b-5p inhibition or TLR4 overexpression averted the inhibitory effect of silencing XIST on HG-induced RTEC pyroptosis. +other 35582589 hsa-mir-126 Colonic Neoplasms The aim was to analyze the relationship between miRNA-126 and EGFL7 and disease recurrence in patients with locally advanced colon cancer treated with neoadjuvant chemotherapy. Conclusion: MicroRNA-126 and EGFL7 are predictors for disease recurrence in patients with locally advanced colon cancer treated with neoadjuvant chemotherapy and may assist in selection of adjuvant chemotherapy. +other 35582584 hsa-mir-203 Breast Neoplasms miR-200c and miR-203 exert a negative modulating effect on the activity of ABCB1 associated with doxorubicin resistance +other 35582584 hsa-mir-200c Breast Neoplasms miR-200c and miR-203 exert a negative modulating effect on the activity of ABCB1 associated with doxorubicin resistance +other 35582270 hsa-mir-16 Mesothelioma, Malignant Results: Expression of miR-15a, miR-16 and miR-34a was downregulated in MPM cells with acquired drug resistance. Taken together, these data suggest that miR-15a, miR-16 and miR-34a are involved in the acquired and intrinsic drug resistance phenotype of MPM cells. +other 35582270 hsa-mir-15a Mesothelioma, Malignant Results: Expression of miR-15a, miR-16 and miR-34a was downregulated in MPM cells with acquired drug resistance. Taken together, these data suggest that miR-15a, miR-16 and miR-34a are involved in the acquired and intrinsic drug resistance phenotype of MPM cells. +other 35582270 hsa-mir-34a Mesothelioma, Malignant Results: Expression of miR-15a, miR-16 and miR-34a was downregulated in MPM cells with acquired drug resistance. Taken together, these data suggest that miR-15a, miR-16 and miR-34a are involved in the acquired and intrinsic drug resistance phenotype of MPM cells. +lncRNA target 35582235 hsa-mir-126 Cerebral Hemorrhage CONCLUSION: miR-126 is downregulated in ICH rats, and miR-126 can reduce brain injury in ICH rats by inhibiting ZEB1 expression. +lncRNA target 35582235 hsa-mir-126 Brain Injuries CONCLUSION: miR-126 is downregulated in ICH rats, and miR-126 can reduce brain injury in ICH rats by inhibiting ZEB1 expression. +circulation_biomarker_diagnosis_up 35582197 hsa-mir-27b Carcinoma, Non-Small-Cell Lung Serum exosomal miR-27b was diminished in NSCLC and was further decreased in the NSCLS-terminal group. +genetics_knock down_promote 35582196 hsa-mir-1258 Carcinoma, Non-Small-Cell Lung Collectively, the knockdown of exosomal circ_0000519 repressed the cell growth and metastasis in NSCLC through the miR-1258/RHOV axis, which provided a new insight into NSCLC development and treatment. +lncRNA target 35581960 hsa-mir-143 Stomach Neoplasms CONCLUSION: Our findings indicate that CASC20 serves as a tumor promoter by regulating metastasis in GC via the miR5p/MEMO1 axis. +genetics_knock down_promote 35581421 hsa-mir-30 prostate adenocarcinoma 3p inhibition blocked the functions of KDM5A knockdown in PRAD. +genetics_knock down_promote 35581180 hsa-mir-624 Carcinoma, Hepatocellular Loss and gain of function experiments demonstrated that regulation of the expression of miR +lncRNA target 35581162 hsa-mir-10a Pancreatitis Circ_0000284 depletion could protect caerulein-induced AR42J cells from apoptosis and inflammation by upregulating miR-10a-5p expression and activating Wnt/beta-catenin pathway, underscoring a potential target for AP therapy. +epigenetics 35580699 hsa-let-7b Carcinoma, Non-Small-Cell Lung Additionally, KDM2B repressed the expression of microRNA (miR)-let-7b-5p through demethylation modification of H3K36me2, thereby promoting the expression of zester homolog 2 (EZH2), the target gene of let-7b-5p in NSCLC. In conclusion, KDM2B induces the EZH2/PKMYT1/Wnt/beta-catenin axis by inhibiting the let-7b-5p expression, which promotes NSCLC growth. +circRNA target 35580464 hsa-mir-142 Angelman Syndrome CONCLUSIONS: Circ_0,003,423 protected HUVECs from ox-LDL-induced dysfunction by sponging miR3p and activating SIRT3/SOD2 signaling, which provided new potential targets for AS intervention and treatment. +genetics_overexpression_promote 35579981 hsa-mir-144 Thyroid Neoplasms 3p reduced proliferation, migration, invasion, and EMT of FRO and KTC3 cells, which was nullified by overexpressing E2F2 or TNIK expression. +other 35579934 hsa-mir-125b Tuberculosis In summary, negative pressure treatment after MTB infection can promote the polarization of macrophages to the proinflammatory M1 phenotype by regulating the XIST/miR-125b-5p/A20/NF-kappaB axis. +genetics_overexpression_promote 35579835 hsa-mir-624 Carcinoma, Hepatocellular Circ_0006404 sponged miR-624 in HCC cell, and the overexpression of circ_0006404 suppressed miR-624 expression in HCC cell. +genetics_knock down_promote 35579772 hsa-mir-24 Multiple Myeloma 5p suppressed the malignant behaviors of MM cells, which were largely counteracted by the overexpression of HGF in MM cells. +other 35579738 hsa-mir-515 Osteosarcoma 5p-SLC7A11 axis in OS cell proliferation and metastasis, which is important in OS monitoring and treatment. +other 35579419 hsa-mir-34a Carcinoma This study is aimed to produce and utilize a new biologic miR-34a-5p (or miR-34a) molecule, namely, hBERA/miR-34a, to delineate the role of miR-34a-5p in the regulation of mitochondrial functions in human carcinoma cells. These results demonstrate the presence and involvement of the miR-34a-5p-MPV17L2 pathway in the control of mitochondrial functions in human carcinoma cells and support the utility of novel bioengineered miRNA molecules for functional studies. +lncRNA target 35579419 hsa-mir-34a Lung Neoplasms hEBRA/miR-34a was processed to target miR-34a-5p in human osteosarcoma and lung cancer cells, as determined by selective stem-loop reverse transcription quantitative polymerase chain reaction analysis. +lncRNA target 35579419 hsa-mir-34a Osteosarcoma hEBRA/miR-34a was processed to target miR-34a-5p in human osteosarcoma and lung cancer cells, as determined by selective stem-loop reverse transcription quantitative polymerase chain reaction analysis. +target gene 35579168 hsa-mir-802 Esophageal Neoplasms Long Non-coding RNA SNHG16 Facilitates Esophageal Cancer Cell Proliferation and Self-renewal through the microRNA-802/PTCH1 Axis. +genetics_knock down_promote 35579106 hsa-mir-145 Acute Lung Injury In contrast, loss of miR +genetics_knock down_promote 35579082 hsa-mir-33a Lymphoma, B-Cell Knockdown of circPCBP2 or miR-33a/b overexpression inhibited the stemness of DLBCL cells and promoted cancer cell apoptosis upon CHOP treatment. +other 35579073 hsa-mir-200c Myocardial Reperfusion Injury In this study, we investigated the effect of ozone on miR-200c expression and the potential role of miR-200c in an I/R myocardial injury model. +lncRNA target 35579073 hsa-mir-200 Myocardial Reperfusion Injury Cell death detected by LDH release and apoptosis assay in the I/R model could also be inhibited by miR-200c inhibitor or ozone treatment. +other 35578792 hsa-mir-143 Infertility, Female Our study highlights a functional micro-regulatory network composed of deubiquitinase (USP9X), small noncoding RNA (miR-143) and the TGF-beta signaling pathway, which plays a crucial role in the regulation of GC apoptosis and female fertility. +other 35578599 hsa-mir-98 Stomach Neoplasms PITPNA-AS1/miR-98-5p to Mediate the Cisplatin Resistance of Gastric Cancer. +other 35578440 hsa-mir-515 Atherosclerosis CONCLUSIONS: HOXA11-AS contributed to atherosclerotic injuries by directly regulating the miR5p/ROCK1 axis. +genetics_knock down_promote 35578338 hsa-mir-494 Esophageal Squamous Cell Carcinoma Furthermore, silencing HDAC3 or overexpressing miR-494 was demonstrated to suppress aggressive phenotypes of ESCC cells both in vitro through the activated TGFbeta signaling pathway and in vivo, while TGIF1 overexpression induced opposite results. +genetics_GWAS 35578240 hsa-mir-129 Carcinoma, Hepatocellular CONCLUSIONS: This study provides detailed insights into the regulatory network of the tumor-suppressive, epigenetically regulated miR +other 35578189 hsa-mir-379 gastric adenocarcinoma 3p). +other 35578189 hsa-mir-2681 gastric adenocarcinoma 3p). +other 35578189 hsa-mir-6807 gastric adenocarcinoma 3p). +other 35578189 hsa-mir-6499 gastric adenocarcinoma 3p). +circulation_biomarker_diagnosis_ns 35578107 hsa-mir-340 Diabetes, Gestational 3p in peripheral blood mononuclear cells (PBMCs) obtained from patients with GDM (n = 42) and healthy controls (n = 34) were evaluated, together with their correlation to the clinical parameters of participants and their newborns. +lncRNA target 35578071 hsa-mir-184 Adenocarcinoma of Lung CONCLUSION: MiR-184 repressed LUAD cell processes via mediating C1QTNF6. +circRNA target 35577924 hsa-mir-19b beta-Thalassemia In conclusion, a novel hsa-circRNA-100466miR-19b-3pSOX6 pathway was identified, providing insight into HbF induction and suggesting targets beta-thalassemia treatment. +other 35577881 hsa-mir-124 Brain Neoplasms Expression analysis of TPD52, KLF14, miR-124, and PKCepsilon provided useful information on the differences existing between the normal brain and SOL, in addition to gliomas; thus, might prove to be useful having diagnostic or prognostic value. +exosome 35577544 hsa-mir-455 Myocardial Reperfusion Injury CONCLUSION: miR3p, shuttled by exosomes from MSCs, targets the MEKK1-MKK4-JNK signaling pathway to guard against myocardial ischemia-reperfusion damage. +other 35577542 hsa-mir-181a Ischemic Stroke 3p were predicted to be the key miRNAs in stroke, and three miRNAs were related to hub gene. +other 35577542 hsa-mir-16 Ischemic Stroke 3p were predicted to be the key miRNAs in stroke, and three miRNAs were related to hub gene. +other 35577542 hsa-mir-124 Ischemic Stroke 3p were predicted to be the key miRNAs in stroke, and three miRNAs were related to hub gene. +genetics_knock down_promote 35576990 hsa-mir-148b Diabetic Nephropathies Gain- and loss-of-function experiments were performed to verify the effects of miR-148b-3p on oxygen-glucose deprivation (OGD)-induced BMEC apoptosis and mitochondrial dysfunction. Mechanistically, circHIPK3 functions as an endogenous sponge of miR-148b-3p to decrease its activity, resulting in upregulation of CDK5R1 and CDK5 expression, downregulation of SIRT1 expression and subsequent BMEC apoptosis and mitochondrial dysfunction. +genetics_knock down_promote 35576990 hsa-mir-148b Ischemic Stroke Gain- and loss-of-function experiments were performed to verify the effects of miR-148b-3p on oxygen-glucose deprivation (OGD)-induced BMEC apoptosis and mitochondrial dysfunction. Mechanistically, circHIPK3 functions as an endogenous sponge of miR-148b-3p to decrease its activity, resulting in upregulation of CDK5R1 and CDK5 expression, downregulation of SIRT1 expression and subsequent BMEC apoptosis and mitochondrial dysfunction. +epigenetics 35576907 hsa-mir-148b Acute Kidney Injury circHIPK3 upregulated DNMT1/3a expression by competitively binding to miR-148b-3p, thus elevating the methylation level of Klotho promoter and accelerating SAKI cell senescence. +other 35576835 hsa-mir-6884 Esophageal Squamous Cell Carcinoma In summary, our study elucidated that E2F1-activated LINC01224 regulated miR5p/DVL3 to actuate the Wnt/beta-catenin signaling pathway, which facilitates multiple phenotype of ESCC cells, including proliferation, migration, and invasion. +genetics_overexpression_promote 35576499 hsa-mir-424 Squamous Cell Carcinoma of Head and Neck 5p overexpression on the process of OSCC cells. +circRNA target 35576496 hsa-mir-143 Osteosarcoma CONCLUSION: The regulation of malignant behaviors such as proliferation, invasion, migration, and multidrug resistance of OS cells by hsa_circ_0001982 may be achieved by targeting miR-143. +other 35576078 hsa-mir-146b Schistosomiasis mansoni We aimed to study the changes in host miRNA-223 and miRNA-146b expression in relation to egg deposition and development of hepatic pathology in murine schistosomiasis mansoni. +other 35576078 hsa-mir-223 Liver Diseases We aimed to study the changes in host miRNA-223 and miRNA-146b expression in relation to egg deposition and development of hepatic pathology in murine schistosomiasis mansoni. +other 35576078 hsa-mir-146b Liver Diseases We aimed to study the changes in host miRNA-223 and miRNA-146b expression in relation to egg deposition and development of hepatic pathology in murine schistosomiasis mansoni. +other 35576078 hsa-mir-146b Schistosomiasis We aimed to study the changes in host miRNA-223 and miRNA-146b expression in relation to egg deposition and development of hepatic pathology in murine schistosomiasis mansoni. +other 35576078 hsa-mir-223 Schistosomiasis We aimed to study the changes in host miRNA-223 and miRNA-146b expression in relation to egg deposition and development of hepatic pathology in murine schistosomiasis mansoni. +other 35576078 hsa-mir-223 Schistosomiasis mansoni We aimed to study the changes in host miRNA-223 and miRNA-146b expression in relation to egg deposition and development of hepatic pathology in murine schistosomiasis mansoni. +circRNA target 35575762 hsa-mir-25 Squamous Cell Carcinoma of Head and Neck CONCLUSION: Our results indicate that has_circ_0069313 induces OSCC immunity escape via the miR3p-Foxp3 axis in both OSCC cells and Treg cells. +genetics_GWAS 35575749 hsa-mir-1275 Colorectal Neoplasms The current study results suggested that HAND2-AS1 gene rs2276941 polymorphism affecting the binding of hsa-miR-1275 was associated with CRC risk and might serve as a CRC susceptibility biomarker. +genetics_overexpression_promote 35575588 hsa-mir-29a Osteosarcoma Overexpressing miR-29a-3p aggravated apoptosis, dampened cell proliferation, colony formation, migration and invasion, and promoted autophagy of OS cells. +lncRNA target 35574307 hsa-mir-17 Colonic Neoplasms Our study suggested that DNMBP-AS1 inhibited the progression of colon cancer through the miR5p/17-5p/NHLRC3 axis, which could be potential therapeutic targets for CC. +lncRNA target 35574307 hsa-mir-93 Colonic Neoplasms Our study suggested that DNMBP-AS1 inhibited the progression of colon cancer through the miR5p/17-5p/NHLRC3 axis, which could be potential therapeutic targets for CC. +other 35574298 hsa-mir-29c Carcinoma, Hepatocellular The CRNDE/LINC00511/SNHG17/HCG18-miR-29c-3p axis was identified as the most likely ncRNA-associated pathway upstream of COMMD2 in LIHC. +lncRNA target 35573679 hsa-mir-21 Reperfusion Injury, Renal Ischemia MiR-21 alleviated renal ischemia-reperfusion injury by inhibiting renal tubular epithelial cell apoptosis. +target gene 35572884 hsa-mir-223 Myocarditis MiR-223-3p affects myocardial inflammation and apoptosis following myocardial infarction via targeting FBXW7. +circRNA target 35572733 hsa-mir-1283 Leukemia, Lymphocytic, Chronic, B-Cell The functional roles of the circZNF91/miR-1283/WEE1 axis in CLL progression were examined by cell proliferation, apoptosis, and EdU incorporation assays. CONCLUSIONS: The circZNF91/miR-1283/WEE1 axis is engaged in the pathological phenotypes of CLL cells, which could serve as potential targets for future therapy development. +transcription factor target 35572727 hsa-mir-489 Neuroblastoma Further studies showed that GPF treatment upregulated miR-489 in NBM cells via activating AMP-activated protein kinase (AMPK). +transcription factor target 35572723 hsa-mir-18a Asthma These compounds interacted with multiple miRNAs, including miR-99a, miR-498, miR-33b, and miR-18a, regulating multiple genes, including JAK, STAT3, EGFR, LYN, and IL-6, in multiple pathways, including those involved in the regulation of JAK-STAT signaling, EGFR tyrosine kinase inhibitor resistance, PI3K-Akt signaling, and inflammation. +transcription factor target 35572723 hsa-mir-498 Asthma These compounds interacted with multiple miRNAs, including miR-99a, miR-498, miR-33b, and miR-18a, regulating multiple genes, including JAK, STAT3, EGFR, LYN, and IL-6, in multiple pathways, including those involved in the regulation of JAK-STAT signaling, EGFR tyrosine kinase inhibitor resistance, PI3K-Akt signaling, and inflammation. +transcription factor target 35572723 hsa-mir-99a Asthma These compounds interacted with multiple miRNAs, including miR-99a, miR-498, miR-33b, and miR-18a, regulating multiple genes, including JAK, STAT3, EGFR, LYN, and IL-6, in multiple pathways, including those involved in the regulation of JAK-STAT signaling, EGFR tyrosine kinase inhibitor resistance, PI3K-Akt signaling, and inflammation. +transcription factor target 35572197 hsa-mir-21 Glioma Overall, we identified miR-21 as a potential target for CRISPR-based therapeutics in glioma. +other 35571741 hsa-mir-29c Colonic Neoplasms CONCLUSION: miR-488, miR-29c-3p, and GDF15 in colon cancer tissue are related to the clinicopathological features of patients in varying degrees and may become markers after early warning of colon cancer, which can provide effective guidance for clinical diagnosis and treatment. +transcription factor target 35571739 hsa-mir-124 Breast Neoplasms 3p/TNF-alpha/TRAF6-related pathway and inhibiting neuronal cell pyroptosis and subsequent inflammation. +transcription factor target 35571739 hsa-mir-124 Depression 3p/TNF-alpha/TRAF6-related pathway and inhibiting neuronal cell pyroptosis and subsequent inflammation. +genetics_overexpression_promote 35571651 hsa-mir-655 Pancreatic Carcinoma Hypomethylation of promoter (P<0.01) and the regulation of hsa-miR-3655 may contribute to the overexpression of GABRP in pancreatic cancer. +genetics_overexpression_promote 35571488 hsa-mir-146b Colonic Neoplasms Overexpressed lncRNA LINC00893 Suppresses Progression of Colon Cancer by Binding with miR-146b-3p to Upregulate PRSS8. +other 35571440 hsa-mir-34a Osteoarthritis CONCLUSIONS: lncRNA MEG3 regulated the expression of FGF23, Bcl-2, Bax, TGF-beta1, Caspase 3, and Caspase 8 by regulating the miR-34a/Klotho axis, thereby affecting the progress of OA. +transcription factor target 35571376 hsa-mir-634 Squamous Cell Carcinoma of Head and Neck mediated targeting of multiple cytoprotective process-related genes, including cellular inhibitor of apoptosis protein 1 (cIAP1), can effectively increase cisplatin (CDDP)-induced cytotoxicity and overcome CDDP resistance in OSCC cells. +other 35571371 hsa-mir-9 Brain Ischemia 5p. +other 35571371 hsa-mir-143 Brain Ischemia 5p. +other 35571371 hsa-mir-124 Brain Ischemia 3p were closely correlated with the evolution of ischemic brain injury, as their expression increased at 0.5 days after the onset of ischemia, peaked at day 1 or 3, and returned to normal levels at day 7 and 14. +other 35571371 hsa-mir-93 Brain Ischemia 5p. +other 35571371 hsa-mir-98 Brain Ischemia 5p. +circulation_biomarker_diagnosis_down 35571250 hsa-mir-122 Respiratory Distress Syndrome In conclusion, adipose-derived circulating exosomal miR5p protects against ARDS by reinforcing pulmonary endothelial barrier through inhibition of EndMT and oxidative stress via down-regulation of the TGF-beta pathway, which propose a potential explanation for the obesity paradox in ARDS and indicate promising prospects for adipose-derived exosomes in cell-free therapies for ARDS. +circulation_biomarker_diagnosis_down 35571250 hsa-mir-122 Obesity In conclusion, adipose-derived circulating exosomal miR5p protects against ARDS by reinforcing pulmonary endothelial barrier through inhibition of EndMT and oxidative stress via down-regulation of the TGF-beta pathway, which propose a potential explanation for the obesity paradox in ARDS and indicate promising prospects for adipose-derived exosomes in cell-free therapies for ARDS. +other 35571247 hsa-mir-3960 Brain Injuries, Traumatic Further analyses revealed that circHtra1 functions as a miR-3960 sponge and increases the expression of GRB10, which is involved in NK cell infiltration after TBI. +other 35571241 hsa-mir-30 Pars Planitis A rescue experiment further showed that circPTP4A2-miR5p-PDK2 signaling was critical to HuMSCs-SF-SIS in decreasing the fibrosis area and increasing the number of glands in the IUA model. +circulation_biomarker_diagnosis_down 35571237 hsa-mir-150 Pulmonary Disease, Chronic Obstructive The plasma miR +circulation_biomarker_diagnosis_ns 35571214 hsa-mir-200c psoriasis 1 Furthermore, NPM positively correlates with miR-200c circulating levels, which we previously showed to increase in Pso and correlate with CVD progression. +circulation_biomarker_diagnosis_ns 35571214 hsa-mir-200c Cardiovascular Diseases Furthermore, NPM positively correlates with miR-200c circulating levels, which we previously showed to increase in Pso and correlate with CVD progression. +other 35571119 hsa-mir-34a Acute Pulmonary Embolism 5p, and miR-449a are downregulated. +other 35571119 hsa-mir-429 Acute Pulmonary Embolism 5p, and miR-449a are downregulated. +other 35571119 hsa-mir-31 Acute Pulmonary Embolism 5p, and miR-449a are downregulated. +other 35571119 hsa-mir-24 Acute Pulmonary Embolism 5p, and miR-449a are downregulated. +other 35571119 hsa-mir-449a Acute Pulmonary Embolism 5p, and miR-449a are downregulated. +other 35571119 hsa-mir-491 Acute Pulmonary Embolism 5p, and miR-449a are downregulated. +lncRNA target 35571024 hsa-mir-25 Carcinoma, Non-Small-Cell Lung Therefore, the LINC01128/miR3p/PTEN axis may promote EGFR-TKI resistance via the PI3K/Akt signaling pathway, which provides new insights into the underlying molecular mechanisms of drug resistance to EGFR-TKIs in NSCLC. +lncRNA target 35571014 hsa-mir-338 Esophageal Squamous Cell Carcinoma Taken together, the circ-0007022/miR3p/NRP1 axis enhances the radiation resistance of ESCC cells via regulating EMT and PI3K/Akt pathway. +circulation_biomarker_diagnosis_up 35570854 hsa-mir-193a Sarcoma, Kaposi Subjects with latent KS infection had a differential upregulation of circulating miR-193a compared to HIV-positive, KS-negative subjects for whom circulating HHV-8 DNA was not detected. +genetics_GWAS 35570745 hsa-mir-1206 Adenocarcinoma of Lung Furthermore, the inhibitory effects of circ_0129047 or BMPR2 overexpression on the malignant phenotype of LAC cells could be reversed by the overexpression of miR-1206. +other 35570481 hsa-mir-370 Wounds and Injuries CONCLUSION: All results revealed that circ_0124644 accelerated endothelial injury in ox-LDL-treated HUVECs by mediating miR3p-related FOXO4 expression. +other 35570299 hsa-mir-211 Diabetic Retinopathy CONCLUSION: MCM3AP-AS1 is downregulated in DR and promotes cell apoptosis by regulating miR-211/SIRT1. +other 35570080 hsa-mir-4523 Obesity Furthermore, in silico analysis revealed generation of new miRNA (hsa-miR-4523) binding site and change in mRNA structure/stability which needs to be further investigated for possible role in altering TLR-2 gene regulation/expression in obesity. +genetics_knock down_suppress 35569812 hsa-mir-1322 Carcinoma, Hepatocellular Circ_0000291 knockdown-mediated anti-tumor impacts in HCC cells were largely overturned by the interference of miR-1322. +genetics_knock down_promote 35569717 hsa-mir-338 Carcinoma, Renal Cell 3p RNA overexpression repressed the malignant phenotypes of RCC cells, while NUCB2 protein elevation could abrogate the effect. +lncRNA target 35569696 hsa-mir-1290 Ovarian Neoplasms Notably, miR-1246 and miR-1290 shuttled in malignant ascites-derived EVs were identified to promote the invasion and migration of ovarian cancer cells through regulating a common target RORalpha. +lncRNA target 35569696 hsa-mir-1246 Ovarian Neoplasms Notably, miR-1246 and miR-1290 shuttled in malignant ascites-derived EVs were identified to promote the invasion and migration of ovarian cancer cells through regulating a common target RORalpha. +lncRNA target 35568971 hsa-mir-618 Tuberculosis, Pulmonary NORAD is a potential diagnostic biomarker for PTB and is involved in Mtb-infected macrophage activity and inflammation by targeting miR-618. +lncRNA target 35568918 hsa-mir-144 Lung Neoplasms 3p may function as a potential therapeutic target in lung cancer treatment in the future. +genetics_knock down_promote 35568813 hsa-mir-214 Osteoporosis 5p knockdown suppressed osteoclast differentiation and prevented bone loss. +other 35568745 hsa-mir-34a Triple Negative Breast Neoplasms In this regard, tsEV could be considered a proper vehicle for miR-34a replacement therapy and could exacerbate its anti-cancer effects in triple-negative breast cancer. +exosome 35568721 hsa-mir-27a Glioblastoma We demonstrated that EV-derived hsa-miR-27a-3p may promote M2 macrophage polarization to induce GBM. +lncRNA target 35567907 hsa-mir-503 Colorectal Neoplasms 5p downregulation suppressed in vitro CRC progression via promoting SALL1 expression. +lncRNA target 35567714 hsa-mir-503 Colorectal Neoplasms 5p/KANK1 axis has critical role in the progression of colorectal cancer, providing an effective prognostic indicator and promising target in treatment of colorectal cancer. +lncRNA target 35567596 hsa-mir-1200 Urinary Bladder Neoplasms This research reveals that circZNF609 improves bladder cancer progression and inhibits cisplatin sensitivity by inducing G1/S cell cycle arrest via a novel miR-1200/CDC25B cascades. +genetics_overexpression_suppress 35567340 hsa-mir-622 Esophageal Squamous Cell Carcinoma The inhibitory effects of miR-622 enrichment on EC cell proliferation, migration, EMT and glutamine metabolism were recovered by SLC1A5 overexpression. CONCLUSION: Circ_0001273 high expression contributed to EC progression via modulating the miR-622/SLC1A5 signaling axis. +other 35566730 hsa-mir-143 Intestinal Neoplasms The expressions of miR-143 and miR-145 were frequently downregulated in SIT and colorectal tumors but not in sessile serrated adenoma/polyp tumors. +other 35566730 hsa-mir-145 Intestinal Neoplasms The expressions of miR-143 and miR-145 were frequently downregulated in SIT and colorectal tumors but not in sessile serrated adenoma/polyp tumors. +other 35566730 hsa-mir-145 Colorectal Neoplasms The expressions of miR-143 and miR-145 were frequently downregulated in SIT and colorectal tumors but not in sessile serrated adenoma/polyp tumors. +other 35566730 hsa-mir-143 Colorectal Neoplasms The expressions of miR-143 and miR-145 were frequently downregulated in SIT and colorectal tumors but not in sessile serrated adenoma/polyp tumors. +circulation_biomarker_prognosis_ns 35566526 hsa-mir-21 Colorectal Neoplasms This study investigated the expressions of plasma/exosomal microRNA-21 (miR-21) in 113 CRC patients by qPCR, their values of predicting CRC recurrence, and the possibility to improve the prognostic efficacy in early CRC recurrence in stratified patients by combined biomarkers including circulating miR-21s, circulating tumour cells/microemboli (CTCs/CTM), and serum carcinoembryonic antigen (CEA)/carbohydrate antigen 19-9 (CA19-9). However, stage IV patients stratified by a high level of exosomal miR-21 and stage I to III patients stratified by a high level of plasma miR-21 displayed significantly worse survival outcomes in predicting CRC recurrence, suggesting their different values to predict CRC recurrence in stratified patients. +genetics_overexpression_promote 35565830 hsa-mir-222 Muscular Atrophy In C2C12 myotubes, both dexamethasone and miR-222 overexpression promoted muscle atrophy, however, this function was significantly reduced after genistein treatment. +other 35565434 hsa-mir-155 Lymphoma, B-Cell We identified a set of five oncogenic microRNAs (miR-19a, miR-20a, miR-21, miR-92a, and miR-155) in CSF that detect, with high sensitivity, secondary CNS lymphoma involvement in aggressive B-NHL, including DLBCL, MCL, and Burkitt lymphoma. +other 35565434 hsa-mir-155 Lymphoma We identified a set of five oncogenic microRNAs (miR-19a, miR-20a, miR-21, miR-92a, and miR-155) in CSF that detect, with high sensitivity, secondary CNS lymphoma involvement in aggressive B-NHL, including DLBCL, MCL, and Burkitt lymphoma. +other 35565434 hsa-mir-19a Lymphoma, B-Cell We identified a set of five oncogenic microRNAs (miR-19a, miR-20a, miR-21, miR-92a, and miR-155) in CSF that detect, with high sensitivity, secondary CNS lymphoma involvement in aggressive B-NHL, including DLBCL, MCL, and Burkitt lymphoma. +other 35565434 hsa-mir-20a Lymphoma, B-Cell We identified a set of five oncogenic microRNAs (miR-19a, miR-20a, miR-21, miR-92a, and miR-155) in CSF that detect, with high sensitivity, secondary CNS lymphoma involvement in aggressive B-NHL, including DLBCL, MCL, and Burkitt lymphoma. +other 35565434 hsa-mir-21 Lymphoma We identified a set of five oncogenic microRNAs (miR-19a, miR-20a, miR-21, miR-92a, and miR-155) in CSF that detect, with high sensitivity, secondary CNS lymphoma involvement in aggressive B-NHL, including DLBCL, MCL, and Burkitt lymphoma. +other 35565434 hsa-mir-21 Lymphoma, B-Cell We identified a set of five oncogenic microRNAs (miR-19a, miR-20a, miR-21, miR-92a, and miR-155) in CSF that detect, with high sensitivity, secondary CNS lymphoma involvement in aggressive B-NHL, including DLBCL, MCL, and Burkitt lymphoma. +other 35565434 hsa-mir-92a Lymphoma, B-Cell We identified a set of five oncogenic microRNAs (miR-19a, miR-20a, miR-21, miR-92a, and miR-155) in CSF that detect, with high sensitivity, secondary CNS lymphoma involvement in aggressive B-NHL, including DLBCL, MCL, and Burkitt lymphoma. +other 35565434 hsa-mir-92a Lymphoma We identified a set of five oncogenic microRNAs (miR-19a, miR-20a, miR-21, miR-92a, and miR-155) in CSF that detect, with high sensitivity, secondary CNS lymphoma involvement in aggressive B-NHL, including DLBCL, MCL, and Burkitt lymphoma. +other 35565434 hsa-mir-19a Lymphoma We identified a set of five oncogenic microRNAs (miR-19a, miR-20a, miR-21, miR-92a, and miR-155) in CSF that detect, with high sensitivity, secondary CNS lymphoma involvement in aggressive B-NHL, including DLBCL, MCL, and Burkitt lymphoma. +other 35565434 hsa-mir-20a Lymphoma We identified a set of five oncogenic microRNAs (miR-19a, miR-20a, miR-21, miR-92a, and miR-155) in CSF that detect, with high sensitivity, secondary CNS lymphoma involvement in aggressive B-NHL, including DLBCL, MCL, and Burkitt lymphoma. +target gene 35565270 hsa-mir-1305 Ovarian Neoplasms Resveratrol Contrasts IL-6 Pro-Growth Effects and Promotes Autophagy-Mediated Cancer Cell Dormancy in 3D Ovarian Cancer: Role of miR-1305 and of Its Target ARH-I. +other 35565239 hsa-mir-195 Colorectal Neoplasms Conclusion: MiR-195 has strong value in predicting time to recurrence in CRC patients. +circulation_biomarker_diagnosis_ns 35563859 hsa-mir-150 Multiple Sclerosis This study identifies miR5p and let-7b-5p packaged in blood myeloid EVs as possible biomarkers for cognitive deficits in MS. +circulation_biomarker_diagnosis_ns 35563859 hsa-let-7b Multiple Sclerosis This study identifies miR5p and let-7b-5p packaged in blood myeloid EVs as possible biomarkers for cognitive deficits in MS. +lncRNA target 35563834 hsa-mir-143a Carcinoma, Hepatocellular The LINC00152-miR-143a-3p-KLC2 axis may represent a therapeutic target in human HCC. +circulation_biomarker_diagnosis_ns 35563810 hsa-mir-126 Inflammation In this paper, a panel of four circulating miRNAs including miR-146a-5p, miR +circulation_biomarker_diagnosis_ns 35563810 hsa-mir-146a Inflammation In this paper, a panel of four circulating miRNAs including miR-146a-5p, miR +circulation_biomarker_diagnosis_ns 35563810 hsa-mir-181a Inflammation In this paper, a panel of four circulating miRNAs including miR-146a-5p, miR +circulation_biomarker_diagnosis_ns 35563810 hsa-mir-21 Inflammation In this paper, a panel of four circulating miRNAs including miR-146a-5p, miR +other 35563647 hsa-mir-185 Fatigue The findings herein point to a promising protein biomarker, phosphoglycerate kinase 1 (PGK1), that was associated with fatigue and displayed changes in abundance in saliva, and we suggest a possible biological mechanism whereby the expression of the PGK1 gene is regulated by miR3185 in response to fatigue. +transcription factor target 35563621 hsa-mir-122 non-alcoholic steatohepatitis Our results suggest that the activation of glycolysis in Kupffer cells during NASH was partially induced by the upregulation of PKM2 via miR5p suppression. +lncRNA target 35563522 hsa-mir-449a Triple Negative Breast Neoplasms The induced expression of microRNA-449a elevated CIN beyond tolerable levels and induced apoptosis in TNBC cell lines by two different mechanisms: (I) promoting chromatid mis-segregation by targeting endonuclease EME1 and (II) inhibiting HDR by downregulating key players of the HDR network such as E2F3, BIRC5, BRCA2 and RAD51. +other 35563501 hsa-mir-669a Periodontitis Out of 378 differentially expressed miRNAs, we identified seven miRNAs (miR-9, miR-148a, miR-669a, miR-199a-3p, miR-1274a, miR-377, and miR-690) in both sexes that may be implicated in the pathogenesis of periodontitis. +other 35563501 hsa-mir-148a Periodontitis Out of 378 differentially expressed miRNAs, we identified seven miRNAs (miR-9, miR-148a, miR-669a, miR-199a-3p, miR-1274a, miR-377, and miR-690) in both sexes that may be implicated in the pathogenesis of periodontitis. +other 35563501 hsa-mir-1274a Periodontitis Out of 378 differentially expressed miRNAs, we identified seven miRNAs (miR-9, miR-148a, miR-669a, miR-199a-3p, miR-1274a, miR-377, and miR-690) in both sexes that may be implicated in the pathogenesis of periodontitis. +other 35563501 hsa-mir-377 Periodontitis Out of 378 differentially expressed miRNAs, we identified seven miRNAs (miR-9, miR-148a, miR-669a, miR-199a-3p, miR-1274a, miR-377, and miR-690) in both sexes that may be implicated in the pathogenesis of periodontitis. +other 35563501 hsa-mir-199a Periodontitis Out of 378 differentially expressed miRNAs, we identified seven miRNAs (miR-9, miR-148a, miR-669a, miR-199a-3p, miR-1274a, miR-377, and miR-690) in both sexes that may be implicated in the pathogenesis of periodontitis. +other 35563501 hsa-mir-690 Periodontitis Out of 378 differentially expressed miRNAs, we identified seven miRNAs (miR-9, miR-148a, miR-669a, miR-199a-3p, miR-1274a, miR-377, and miR-690) in both sexes that may be implicated in the pathogenesis of periodontitis. +other 35563501 hsa-mir-9 Periodontitis Out of 378 differentially expressed miRNAs, we identified seven miRNAs (miR-9, miR-148a, miR-669a, miR-199a-3p, miR-1274a, miR-377, and miR-690) in both sexes that may be implicated in the pathogenesis of periodontitis. +lncRNA target 35563442 hsa-mir-205 Colonic Neoplasms An inhibitor of miR-205 could recover Bcl2 expression and promoted the survival of CC cells upon DET treatment. +tissue_expression_ns 35563413 hsa-mir-20a Hypercholesterolemia In the present study, we evaluated the expression of hsa-miR5p, hsa-miR-20a-5p and hsa-miR-106a-5p in hypercholesterolemic patients before and after atorvastatin treatment and in HepG2 cells treated for 24 h with atorvastatin The miRNA hsa-mir-20a-5p was repressed after atorvastatin treatment in hypercholesteremic subjects and in HepG2 cells in culture. +tissue_expression_ns 35563413 hsa-mir-106a Hypercholesterolemia In the present study, we evaluated the expression of hsa-miR5p, hsa-miR-20a-5p and hsa-miR-106a-5p in hypercholesterolemic patients before and after atorvastatin treatment and in HepG2 cells treated for 24 h with atorvastatin The miRNA hsa-mir-20a-5p was repressed after atorvastatin treatment in hypercholesteremic subjects and in HepG2 cells in culture. +tissue_expression_ns 35563413 hsa-mir-17 Hypercholesterolemia In the present study, we evaluated the expression of hsa-miR5p, hsa-miR-20a-5p and hsa-miR-106a-5p in hypercholesterolemic patients before and after atorvastatin treatment and in HepG2 cells treated for 24 h with atorvastatin The miRNA hsa-mir-20a-5p was repressed after atorvastatin treatment in hypercholesteremic subjects and in HepG2 cells in culture. +other 35563410 hsa-mir-27b Leukemia The results showed that the level of selected miRNAs correlates with the level of proteins, especially p27, Bak1, NFkappaB, and CYP24A1, and miR-27b and miR-125b could be responsible for the anticancer activity of active forms of vitamin D(3) in human leukemia and lymphoma. +other 35563410 hsa-mir-125b Leukemia The results showed that the level of selected miRNAs correlates with the level of proteins, especially p27, Bak1, NFkappaB, and CYP24A1, and miR-27b and miR-125b could be responsible for the anticancer activity of active forms of vitamin D(3) in human leukemia and lymphoma. +genetics_overexpression_promote 35563301 hsa-mir-155 Cholangitis, Sclerosing, Primary In contrast, the absence of miR-155 overexpression in the sigmoid colon of PSC-UC patients activated the Il-6/S1PR1 signalling pathway and imbalanced the IL17/FOXP3 ratio, which reinforces chronic colitis. +other 35563269 hsa-mir-196b Adenocarcinoma, Sebaceous, Ocular At least two miRNAs, miR-196b-5p (p 0.05) and miR-107 (p 0.001), displayed a statistically significant differential expression between OSCs and SCCCs with miR-196b-5p upregulated in SCCCs and miR-107 upregulated in OSCs. In conclusion, the combined testing of miR-196b-5p and miR-107, can be of additional use in routine diagnostics to discriminate OSCs from SCCCs. +other 35563269 hsa-mir-107 Adenocarcinoma, Sebaceous, Ocular At least two miRNAs, miR-196b-5p (p 0.05) and miR-107 (p 0.001), displayed a statistically significant differential expression between OSCs and SCCCs with miR-196b-5p upregulated in SCCCs and miR-107 upregulated in OSCs. In conclusion, the combined testing of miR-196b-5p and miR-107, can be of additional use in routine diagnostics to discriminate OSCs from SCCCs. +other 35563178 hsa-mir-5100 Stomach Neoplasms The effect and regulatory mechanism of DEK on autophagy and apoptosis in gastric cancer (GC), and the role between miR-5100 and DEK or miR-5100 and LEF1-AS1 are still unclear. In conclusion, our results found that LEF1-AS1 and miR-5100 sponge function, and the miR-5100/DEK/AMPK/mTOR axis regulates autophagy and apoptosis in gastric cancer cells. +exosome 35563123 hsa-mir-221 Aortic Aneurysm, Thoracic TAA-TC-exosomes showed a significant increase of the SMC-related dedifferentiation markers KLF, VEGF-A-, and PDGF-A-protein levels, as well as miRNA-expression levels of miR-146a, miR-221 and miR-222. +exosome 35563123 hsa-mir-146a Aortic Aneurysm, Thoracic TAA-TC-exosomes showed a significant increase of the SMC-related dedifferentiation markers KLF, VEGF-A-, and PDGF-A-protein levels, as well as miRNA-expression levels of miR-146a, miR-221 and miR-222. +exosome 35563123 hsa-mir-222 Aortic Aneurysm, Thoracic TAA-TC-exosomes showed a significant increase of the SMC-related dedifferentiation markers KLF, VEGF-A-, and PDGF-A-protein levels, as well as miRNA-expression levels of miR-146a, miR-221 and miR-222. +other 35563053 hsa-mir-125b-1 endometriosis in scar of skin 3p are consistent with the benign nature of SE. +other 35563053 hsa-mir-1 endometriosis in scar of skin 3p are consistent with the benign nature of SE. +lncRNA target 35563023 hsa-mir-29b Hand, Foot and Mouth Disease We further predicted that novel_circ_0002006 might act as a molecular sponge for miR3p through the IFN-I pathway to inhibit CVB5 replication, and that novel_circ_0001066 might act as a molecular sponge for miR-29b-3p via the NF-kappaB pathway and for the inhibition of CVB5 replication. +lncRNA target 35563023 hsa-mir-152 Hand, Foot and Mouth Disease We further predicted that novel_circ_0002006 might act as a molecular sponge for miR3p through the IFN-I pathway to inhibit CVB5 replication, and that novel_circ_0001066 might act as a molecular sponge for miR-29b-3p via the NF-kappaB pathway and for the inhibition of CVB5 replication. +other 35562921 hsa-mir-19a Ischemic Stroke Patients with moderate stroke had significantly elevated miR-19a-3p expression levels compared to patients with minor stroke at the first day of IS. +genetics_overexpression_promote 35562411 hsa-mir-148a Nasopharyngeal Carcinoma Silencing of SRGN and CREB1, as well as miR-148a-5p overexpression, repressed NPC tumor progression in vitro and in vivo. +other 35562351 hsa-mir-17 Alzheimer Disease TARBP2/SNHG7/miR5p/NFATC3 pathway implied a potential mechanism in studies of BBB changes in AD pathological progression. +lncRNA target 35562348 hsa-mir-147a Prostatic Neoplasms Collectively, RP1-59D14.5 promoted yes-associated protein (YAP) degradation to activate the Hippo pathway in PCa progression via targeting the miR-147a/LATS1/2 axis and recruiting HUR to promote the interaction of CK1 and -transducin repeat-containing protein (TrCP). +lncRNA target 35562342 hsa-mir-378a Carcinoma, Renal Cell Our results support that the DMDRMR/miR-378a-5p/DAB2IP axis may serve as a novel target for combination diagnosis or therapy of ccRCC patients. +lncRNA target 35562181 hsa-mir-221 Thyroid Neoplasms We have identified a likely operative post-transcriptional regulatory network in which the downregulated lncRNA, SPTY2D1-AS1, is predicted to target the most abundant and upregulated miRNAs in thyroid cancer, particularly miR-221, a well-known oncomiRNA in cancer. Indeed, SPTY2D1-AS1 functions as a potent tumor suppressor in vitro and in vivo, it is downregulated in the most advanced stages of human thyroid cancer, and it seems to block the processing of the primary form of miR-221. +circulation_biomarker_diagnosis_ns 35561893 hsa-mir-532 Multiple Myeloma RESULTS: MM serum increased the expressions of TF and miR-532, induced thrombin generation, inhibited EPCR and protein C activation in HUVECs. And metformin could reverse the effects of MM serum on the expressions of TF, EPCR and miR-532, thrombin generation, protein C activation in HUVECs. +genetics_GWAS 35561450 hsa-mir-4423 Multiple Sclerosis On the other hand, the MS risk allele A of SNP rs817478, which substitutes the first C in a CNNC sequence motif, was found to cause a markedly lower efficiency in the processing of hsa-mir-4423. +other 35561231 hsa-mir-503 Obesity miR-130a (pro-angiogenic) was approximately 1.4-fold (P = 0.011) and miR-503 (anti-angiogenic) approximately 1.8-fold (P = 0.017) greater in OB compared with LN subjects at all time points. +other 35560511 hsa-let-7c Lung Diseases Collectively, CuE protected against nicotine-induced airway remodelling and partially depended on the induction of let-7c-5p; our future work would pay more attention to other downstream effectors of the miR to promote the treatment of nicotine-induced pulmonary disorders. +lncRNA target 35560511 hsa-let-7c Tobacco Use Disorder Changes in viability, inflammation and let-7c-5p/NGF pathway in nicotine-treated bronchial epithelial cells (BECs) were detected under CuE treatment (5 muM). +genetics_GWAS 35560017 hsa-let-7b Endometriosis CONCLUSION(S): We identified differential Let-7b methylation in endometriosis, demonstrating that the epigenetic nature of the disease extends to the regulation of miRNAs. +other 35559743 hsa-mir-23b Uterine Hemorrhage CONCLUSION(S): Reduced expression of the miR-23b-3p/24-3p/27b-3p cluster is associated with elevated expression of CXCL12, which may contribute to the pathophysiology of AUB. +other 35559420 hsa-mir-671 Breast Neoplasms YY1 as a promoter regulating the circ_0001946/miR-671-5p/EGFR axis to promote chemotherapy resistance in breast cancer cells. +target gene 35559394 hsa-mir-107 Breast Neoplasms LncRNA TTN-AS1 confers tamoxifen resistance in breast cancer via sponging miR-107 to modulate PI3K/AKT signaling pathway. +lncRNA target 35559382 hsa-mir-122 Liver Cirrhosis CONCLUSION: Circ_MTM1 could serve as a promoter in HBV-related LF through miR +lncRNA target 35559382 hsa-mir-122 Hepatitis B, Chronic CONCLUSION: Circ_MTM1 could serve as a promoter in HBV-related LF through miR +other 35559021 hsa-mir-199a Pleomorphic Sarcoma, Undifferentiated After verification, the relative expressions of hsa-miR-199a-3p and hsa-miR-34a-5p were increased and decreased in the UPS tumor tissue compared with those in the adjacent normal tissue, respectively. Conclusion: NF1 and NF1-related microRNAs including hsa-miR-199a-3p and hsa-miR-34a-5p may be novel biomarkers in the diagnosis of undifferentiated pleomorphic sarcoma (UPS). +other 35559021 hsa-mir-34a Pleomorphic Sarcoma, Undifferentiated After verification, the relative expressions of hsa-miR-199a-3p and hsa-miR-34a-5p were increased and decreased in the UPS tumor tissue compared with those in the adjacent normal tissue, respectively. Conclusion: NF1 and NF1-related microRNAs including hsa-miR-199a-3p and hsa-miR-34a-5p may be novel biomarkers in the diagnosis of undifferentiated pleomorphic sarcoma (UPS). +therapeutic target 35558599 hsa-mir-4516 Stomach Neoplasms A microRNA-4516 inhibitor sensitizes chemo-resistant gastric cancer cells to chemotherapy by upregulating ING4. +lncRNA target 35558291 hsa-mir-873 Granulomatosis with Polyangiitis 5p inhibitor activated the p38/Nrf2/HO-1 signaling pathway in KGN cells. +lncRNA target 35558291 hsa-mir-873 Polycystic Ovary Syndrome The findings may provide insightful evidence for preventing and treating PCOS by targeting miR +lncRNA target 35558099 hsa-mir-125b Growth Hormone-Secreting Pituitary Adenoma Interestingly, microRNA (miR)-125b, which is one of the most abundantly expressed small RNAs in U-exo, was found to suppress IFV replication possibly via the induction of IFN-stimulated genes (ISGs). +other 35558077 hsa-mir-10b nonpapillary renal cell carcinoma Finally, we predicted a key SNHG3/AL513497.1-miR-10b-5p-TRPV3 axis linking to carcinogenesis and progression of ccRCC. +exosome 35557942 hsa-mir-122 Rectal Injury Hypoxic EV-derived miR5p plays a critical pathologic role in radiation-induced rectal injury and may be a potential therapeutic target. +target gene 35557905 hsa-mir-214 Carcinoma, Non-Small-Cell Lung LncRNA CASC2 inhibits autophagy and promotes apoptosis in non-small cell lung cancer cells via regulating the miR-214/TRIM16 axis. +genetics_overexpression_suppress 35557748 hsa-mir-217 Fibrosis, Renal Overexpressed ZEB1-AS1 may inhibit renal fibrosis in diabetic nephropathy by regulating the miR-217/MAFB axis, identifying novel therapeutic targets for renal fibrosis in diabetic nephropathy. +genetics_overexpression_suppress 35557748 hsa-mir-217 Diabetic Nephropathies Overexpressed ZEB1-AS1 may inhibit renal fibrosis in diabetic nephropathy by regulating the miR-217/MAFB axis, identifying novel therapeutic targets for renal fibrosis in diabetic nephropathy. +exosome 35557596 hsa-mir-142 Carcinoma, Hepatocellular Exosomal miR-142-3p secreted by hepatitis B virus (HBV)-hepatocellular carcinoma (HCC) cells promotes ferroptosis of M1-type macrophages through SLC3A2 and the mechanism of HCC progression. +circulation_biomarker_diagnosis_ns 35557515 hsa-mir-21 limb ischemia In patients with limb ischemia, the high expression of circulating miR-21 was associated with less subsequent MALE. Additionally, abolishing miR-21 impairs angiogenesis and promotes apoptosis post limb ischemia. +circulation_biomarker_diagnosis_ns 35557032 hsa-mir-34a Carcinoma, Ovarian Epithelial The relative expression level of microRNA-34a, let-7f, and microRNA-31 was found to be significantly reduced in early-stage EOC tissues and serum samples (p<0.0001). The receiver operating characteristic analysis of microRNA-34a, let-7f and miR-31 showed improved diagnostic value with area under curve(AUC) of 92.0 (p<0.0001), 87.9 (p<0.0001), and 85.6 (p<0.0001) and AUC of 82.7 (p<0.0001), 82.0 (p<0.0001), and 81.0 (p<0.0001) in stage III-IV and stage I-II EOC serum samples respectively. +circulation_biomarker_diagnosis_ns 35557032 hsa-let-7f Carcinoma, Ovarian Epithelial The relative expression level of microRNA-34a, let-7f, and microRNA-31 was found to be significantly reduced in early-stage EOC tissues and serum samples (p<0.0001). The receiver operating characteristic analysis of microRNA-34a, let-7f and miR-31 showed improved diagnostic value with area under curve(AUC) of 92.0 (p<0.0001), 87.9 (p<0.0001), and 85.6 (p<0.0001) and AUC of 82.7 (p<0.0001), 82.0 (p<0.0001), and 81.0 (p<0.0001) in stage III-IV and stage I-II EOC serum samples respectively. +circulation_biomarker_diagnosis_ns 35557032 hsa-mir-1 Carcinoma, Ovarian Epithelial The relative expression level of microRNA-34a, let-7f, and microRNA-31 was found to be significantly reduced in early-stage EOC tissues and serum samples (p<0.0001). The receiver operating characteristic analysis of microRNA-34a, let-7f and miR-31 showed improved diagnostic value with area under curve(AUC) of 92.0 (p<0.0001), 87.9 (p<0.0001), and 85.6 (p<0.0001) and AUC of 82.7 (p<0.0001), 82.0 (p<0.0001), and 81.0 (p<0.0001) in stage III-IV and stage I-II EOC serum samples respectively. +lncRNA target 35554780 hsa-mir-26a Osteoporosis, Diabetic In a word, USCs-EVs-miR-26a-5p is a promising therapy for DOP by activating HIF-1alpha/VEGFA pathway through HDAC4 inhibition. +other 35553409 hsa-mir-6884 Ovarian Neoplasms In summary, our research verified the PART1/miR5p/RACGAP1/RRM2 axis in OC cells, which signified that PART1 might act as a novel biomarker in OC. +circulation_biomarker_diagnosis_up 35553331 hsa-mir-34a Coronary Artery Disease However, the expression of miR-34a, miR-149 in the plasma of CAD patients was not significantly different with the control group. +circulation_biomarker_diagnosis_up 35553331 hsa-mir-149 Coronary Artery Disease However, the expression of miR-34a, miR-149 in the plasma of CAD patients was not significantly different with the control group. +other 35553329 hsa-let-7a nephrotic syndrome type 1 The differential expression of microRNA let-7a is useful to discriminate SSNS and SRNS. +other 35552758 hsa-mir-4486 Endometrial Hyperplasia To conclude, MET exhibited a therapeutic effect in the treatment of EH by modulating the lncRNAMEG3/miR223/GLUT4 and lncRNASNHG20/miR4486/GLUT4 signaling pathways. +other 35552758 hsa-mir-4486 Polycystic Ovary Syndrome To conclude, MET exhibited a therapeutic effect in the treatment of EH by modulating the lncRNAMEG3/miR223/GLUT4 and lncRNASNHG20/miR4486/GLUT4 signaling pathways. +other 35552758 hsa-mir-223 Endometrial Hyperplasia To conclude, MET exhibited a therapeutic effect in the treatment of EH by modulating the lncRNAMEG3/miR223/GLUT4 and lncRNASNHG20/miR4486/GLUT4 signaling pathways. +other 35552758 hsa-mir-223 Polycystic Ovary Syndrome To conclude, MET exhibited a therapeutic effect in the treatment of EH by modulating the lncRNAMEG3/miR223/GLUT4 and lncRNASNHG20/miR4486/GLUT4 signaling pathways. +other 35552175 hsa-mir-204 Hypertension, Pulmonary RESULTS: mRNA expressions of hypoxia-inducible factor-2 alpha, signal transducer and activator of transcription-33, and FGF-2 were increased; miRNA-210 and miRNA-130a were increased; miRNA-223 and miRNA-204 were decreased in pulmonary hyperten-sion. +other 35552175 hsa-mir-223 Hypertension, Pulmonary RESULTS: mRNA expressions of hypoxia-inducible factor-2 alpha, signal transducer and activator of transcription-33, and FGF-2 were increased; miRNA-210 and miRNA-130a were increased; miRNA-223 and miRNA-204 were decreased in pulmonary hyperten-sion. +other 35552175 hsa-mir-210 Hypertension, Pulmonary RESULTS: mRNA expressions of hypoxia-inducible factor-2 alpha, signal transducer and activator of transcription-33, and FGF-2 were increased; miRNA-210 and miRNA-130a were increased; miRNA-223 and miRNA-204 were decreased in pulmonary hyperten-sion. +other 35552172 hsa-mir-423 Heart Failure 5p was implicated in left ventricular hypertrophy and might be a potential biomarker for assessing the therapeutic effect of cardiac rehabilitation on hypertensive patients with heart failure with a moderately reduced ejection fraction. +other 35552172 hsa-mir-423 Hypertension 5p was implicated in left ventricular hypertrophy and might be a potential biomarker for assessing the therapeutic effect of cardiac rehabilitation on hypertensive patients with heart failure with a moderately reduced ejection fraction. +other 35552087 hsa-mir-30 Carcinoma, Non-Small-Cell Lung 5p/HMGA2 axis. +lncRNA target 35551606 hsa-mir-144 Breast Neoplasms CONCLUSION: LINC00662 enhances cell proliferation, migration, invasion and stemness in BC by targeting miR +lncRNA target 35551487 hsa-mir-155 Inflammation Based on the specific patterns of expression in gastritis and cancer, CD9, MST1R, and ADAM10 were candidates for the most probable targets of miR +transcription factor target 35551348 hsa-mir-146a Fibrosis, Renal 5p may play an inhibitory role. +transcription factor target 35551348 hsa-mir-148a Fibrosis, Renal 5p may play an inhibitory role. +transcription factor target 35551348 hsa-mir-362 Fibrosis, Renal 5p may play an inhibitory role. +transcription factor target 35551348 hsa-mir-122 Fibrosis, Renal 5p may play an inhibitory role. +transcription factor target 35551348 hsa-mir-130a Fibrosis, Renal 5p may play an inhibitory role. +lncRNA target 35550840 hsa-mir-223 Parkinson Disease Overall, DLX6-AS1 promotes the microglial inflammatory response in PD through the ceRNA mechanism of miR3p/NRP1. +other 35550634 hsa-mir-126 Diabetes Mellitus, Type 1 METHODS: We measured urine free Retinol-binding protein 4 (UfRBP4), albumin (UAlb), Kidney injury molecule-1 (KIM-1) and the microRNAs miR-155, miR-126 and miR-29b in two cohorts of paediatric T1DM patients without evidence of DKD, but with diabetes of short-duration, /= 10 years (LD, n = 29); non-diabetic siblings (H, n = 26) were recruited as controls. +other 35550634 hsa-mir-29b Diabetes Mellitus, Type 1 METHODS: We measured urine free Retinol-binding protein 4 (UfRBP4), albumin (UAlb), Kidney injury molecule-1 (KIM-1) and the microRNAs miR-155, miR-126 and miR-29b in two cohorts of paediatric T1DM patients without evidence of DKD, but with diabetes of short-duration, /= 10 years (LD, n = 29); non-diabetic siblings (H, n = 26) were recruited as controls. +other 35550634 hsa-mir-155 Diabetes Mellitus, Type 1 METHODS: We measured urine free Retinol-binding protein 4 (UfRBP4), albumin (UAlb), Kidney injury molecule-1 (KIM-1) and the microRNAs miR-155, miR-126 and miR-29b in two cohorts of paediatric T1DM patients without evidence of DKD, but with diabetes of short-duration, /= 10 years (LD, n = 29); non-diabetic siblings (H, n = 26) were recruited as controls. +other 35550634 hsa-mir-29b Diabetic Nephropathies METHODS: We measured urine free Retinol-binding protein 4 (UfRBP4), albumin (UAlb), Kidney injury molecule-1 (KIM-1) and the microRNAs miR-155, miR-126 and miR-29b in two cohorts of paediatric T1DM patients without evidence of DKD, but with diabetes of short-duration, /= 10 years (LD, n = 29); non-diabetic siblings (H, n = 26) were recruited as controls. +other 35550634 hsa-mir-126 Diabetic Nephropathies METHODS: We measured urine free Retinol-binding protein 4 (UfRBP4), albumin (UAlb), Kidney injury molecule-1 (KIM-1) and the microRNAs miR-155, miR-126 and miR-29b in two cohorts of paediatric T1DM patients without evidence of DKD, but with diabetes of short-duration, /= 10 years (LD, n = 29); non-diabetic siblings (H, n = 26) were recruited as controls. +other 35550634 hsa-mir-155 Diabetic Nephropathies METHODS: We measured urine free Retinol-binding protein 4 (UfRBP4), albumin (UAlb), Kidney injury molecule-1 (KIM-1) and the microRNAs miR-155, miR-126 and miR-29b in two cohorts of paediatric T1DM patients without evidence of DKD, but with diabetes of short-duration, /= 10 years (LD, n = 29); non-diabetic siblings (H, n = 26) were recruited as controls. +circRNA target 35549985 hsa-mir-582 Adenocarcinoma of Lung 3p inhibitor decreased lung cancer cell proliferation and promoted apoptosis. +exosome 35549815 hsa-mir-21 Osteoporosis Bone mesenchymal stem cells (BMSCs)-derived exosomes (Exos) play important roles in osteoporosis, while the regulation of microRNA (miR)5p remains unclear. +genetics_overexpression_promote 35549813 hsa-mir-661 Melanoma miR-661 overexpression partially reversed hsa_circ_0103232 promoting effect on melanoma cells viability, proliferation, migration, invasion, and EMT (P < 0.01). +lncRNA target 35549806 hsa-mir-1290 Esophageal Neoplasms Thus, circ_0086414 inhibited EC cell malignancy through the miR-1290/SPARCL1 pathway, providing a reliable target for the therapy of EC. +lncRNA target 35549803 hsa-mir-4306 Osteoarthritis CONCLUSION: CircPDE4D and miR-4306 were important regulators in regulating IL-1beta-induced HNC apoptosis and matrix degradation via regulating the key transcription factor SOX9, suggesting a novel circPDE4D/miR-4306/SOX9 ceRNA pathway in OA-related chondrocyte dysfunction. +transcription factor target 35549788 hsa-mir-140 Arthritis, Rheumatoid CONCLUSION: SP can alleviate RA by promoting the expression of miR +genetics_overexpression_promote 35549691 hsa-mir-107 Breast Neoplasms Overexpression of miR-107 suppressed the expression of NEDD9, thereby inhibiting the invasion, migration and proliferation of BC cells, but interference with miR-107 promoted the expression of NEDD9 as well as invasion, migration and proliferation. +lncRNA target 35549643 hsa-mir-24 Ovarian Neoplasms Hence, we demonstrate that miR3p suppressed ovarian cancer progression by targeting the WNK2/RAS pathway. +lncRNA target 35549631 hsa-mir-148b Carcinoma, Non-Small-Cell Lung In summary, circ_0120376 contributes to the malignancy of NSCLC cells through a ceRNA mechanism via regulating miR-148b-3p/CEP55 axis. +target gene 35549438 hsa-mir-626 Squamous Cell Carcinoma of Head and Neck miR-626 Inhibition Enhanced the Radiosensitivity to Oral Squamous Cell Carcinoma via the Downregulation of Nuclear Factor Kappa-B Signaling. +transcription factor target 35548888 hsa-mir-26a Osteoarthritis CONCLUSION: Our study suggested that hypoxic USC-EVs may represent a promising strategy for osteoarthritis by promoting the proliferation and migration of chondrocytes via miR-26a-5p transfer. +exosome 35548775 hsa-mir-146a Myocardial Infarction Initially, we found that exosomes with low expression of miR-146a-5p derived from myocardial infarction tissues modulated macrophage polarization. Exosomal miR-146a-5p plays important roles in macrophages, illuminating a novel potential therapeutic target in myocardial infarction. +lncRNA target 35547763 hsa-mir-23a Brain Ischemia Conclusion: Our results demonstrated that M2 microglia could communicate to OPCs through M2-EVs and promote white matter repair via miR-23a-5p possibly by directly targeting Olig3 after ischemic stroke, suggesting M2-EVs is a novel and promising therapeutic strategy for white matter repair in stroke and demyelinating disease. +lncRNA target 35547289 hsa-mir-613 Squamous Cell Carcinoma of Head and Neck SNAI2 axis on EMT and drug resistance in LSCC, providing new targets for LSCC diagnosis and treatment. +other 35547243 hsa-mir-495 Coronary Occlusion The expression of miRNA-494, miRNA-495 and miRNA-329 were all significantly down-regulated in CTO patients and they were confirmed to be down-regulated in another cohort of 68 patients. +other 35547243 hsa-mir-494 Coronary Occlusion The expression of miRNA-494, miRNA-495 and miRNA-329 were all significantly down-regulated in CTO patients and they were confirmed to be down-regulated in another cohort of 68 patients. +other 35547243 hsa-mir-29 Coronary Occlusion The expression of miRNA-494, miRNA-495 and miRNA-329 were all significantly down-regulated in CTO patients and they were confirmed to be down-regulated in another cohort of 68 patients. +lncRNA target 35546848 hsa-mir-155 Breast Neoplasms MicroRNA-155 regulates the expression of 147 target genes that are involved in cancer pathways, and its expression level has been shown to be up-regulated in breast cancer. +circRNA target 35546509 hsa-mir-195 Endometrial Neoplasms 5p, which could provide pivotal potential therapeutic targets for the treatment of EC. +lncRNA target 35545863 hsa-mir-143 Stomach Neoplasms 3p/IGF1R axis, suggesting that circ_0006089 may serve as a promising therapeutic target for GC. +genetics_knock down_promote 35545774 hsa-mir-155 Dermatitis, Atopic The interaction among IL-32, JAK1 and miR-155 was identified with their roles in AD analyzed through loss- and gain-of-function assays. +circRNA target 35545766 hsa-mir-513a Nasopharyngeal Carcinoma CONCLUSION: Hsa_circ_0000345 inhibits cell proliferation, migration and invasion of NPC cells via miR-513a-3p/PTEN axis, thereby suppressing the progression of NPC. +other 35545753 hsa-mir-155 Scleroderma, Systemic 5p are critical for SSc progression, which may provide novel insights into the pathogenesis of SSc. +genetics_overexpression_promote 35545731 hsa-mir-27a Squamous Cell Carcinoma of Head and Neck Smad4 was downregulated in LSCC tissues, and simultaneous overexpression of miR-27a and Smad4 resulted in reduced cell activity and tumorigenicity. +lncRNA target 35545654 hsa-mir-214 Glioma Collectively, our research discovered the potential signaling mechanism associated with C3G-mediated suppression of TMZ resistance in LN-18/TR cells through miR +lncRNA target 35545535 hsa-mir-508 Diabetes, Gestational Collectively, circ_FOXP1 promotes the growth and survival of HG-treated human trophoblast cells through the miR3p/SMAD2 pathway, hinting that circ_FOXP1 was involved in GDM progression. +lncRNA target 35545369 hsa-mir-23a Colorectal Neoplasms 5p, can compete for endogenous RNA through direct interaction with miR-323a-3p and miR +lncRNA target 35545369 hsa-mir-532 Colorectal Neoplasms 5p, can compete for endogenous RNA through direct interaction with miR-323a-3p and miR +other 35545365 hsa-mir-1 Alopecia CONCLUSIONS: HSP27 could combine with miR-1 to up-regulate AR levels, which is closely related to the development of AGA. +other 35545360 hsa-mir-16 Autoimmune polyendocrinopathy syndrome, type 1 CONCLUSIONS: APS can regulate the miR-16/NF-kappaB signaling pathway, thereby affecting the levels of MDR1 and P-gp170, and reducing the inflammation in the kidney tissues in the adriamycin nephropathy rats. +other 35545360 hsa-mir-16 Adenine phosphoribosyltransferase deficiency CONCLUSIONS: APS can regulate the miR-16/NF-kappaB signaling pathway, thereby affecting the levels of MDR1 and P-gp170, and reducing the inflammation in the kidney tissues in the adriamycin nephropathy rats. +other 35545337 hsa-mir-450b Colorectal Neoplasms Real-time PCR results showed that the expression levels of hsa_circRNA_0065173, ADCY5, CHRM2, CNR1 and LPAR1 in the CRC tissues were significantly reduced compared with the adjacent normal tissues (all P<0.05); the expression levels of hsa-mir-450b and hsa-miR-582 were significantly increased (both P<0.05). +genetics_knock down_promote 35545336 hsa-mir-133b Urinary Bladder Neoplasms Both overexpression of miR-133b and knockdown of SOX4 significantly inhibited the proliferation, colony formation, and invasion capacity of bladder cancer cells in vitro. +lncRNA target 35545320 hsa-mir-223 Acute Lung Injury Compared with the model group, the W/D value of lungs, lung injury score, and levels of inflammatory factors in bronchoalveolar lavage fluid were significantly decreased in the chlorogenic acid group, the chlorogenic acid+miR-223 NC group, and the chlorogenic acid+miR-223 antagomir group (all P<0.05); lung tissues damage was alleviated; the numbers of EOS, lymphocytes, and neutrophils in bronchoalveolar lavage fluid were significantly decreased (all P<0.05); the expression levels of miR-223 in lung tissues were significantly increased (P<0.05); and the expression levels of NLRP3 protein were significantly decreased (P<0.05). +genetics_overexpression_promote 35543855 hsa-mir-19a Stomach Neoplasms TCGA-based expression analysis and qRT-PCR assay illustrated that microRNA-19a-3p was overexpressed in gastric cancer. +other 35543802 hsa-mir-4685 Schizophrenia 3p/UBE2K axes have the greatest probability of being involved in the pathophysiology of SCZ. +other 35543802 hsa-mir-127 Schizophrenia 3p/UBE2K axes have the greatest probability of being involved in the pathophysiology of SCZ. +exosome 35543792 hsa-mir-556 Cardiomyopathies CONCLUSION: Lnc A2M-AS1 delivery via MSC-derived exosomes ameliorated H/R-induced cardiomyocyte apoptosis and oxidative stress via regulating miR5p/XIAP, opening a new window into the pathogenesis of myocardial I/R injury. +genetics_overexpression_suppress 35543644 hsa-mir-143 Cancer Pain Overexpression of miR +circRNA target 35543435 hsa-mir-22 Lupus Erythematosus, Systemic CONCLUSIONS: Collectively, circRACGAP1 regulated the AKT signalling pathway via binding to miR3p in the progression of SLE, suggesting therapeutic targets for SLE treatment. +lncRNA target 35543383 hsa-mir-139 Depression 5p inhibition plays an antidepressant-like role and might serve as an effective depression target (Fig. +lncRNA target 35543246 hsa-mir-1247 Carcinoma, Squamous Cell, Cutaneous 5p suppressed CSCC cell progression by inhibiting CSF3. +target gene 35542225 hsa-mir-21 Carcinoma, Non-Small-Cell Lung Long non-coding RNA CASC2 enhanced cisplatin-induced viability inhibition of non-small cell lung cancer cells by regulating the PTEN/PI3K/Akt pathway through down-regulation of miR-18a and miR-21. +target gene 35542225 hsa-mir-18a Carcinoma, Non-Small-Cell Lung Long non-coding RNA CASC2 enhanced cisplatin-induced viability inhibition of non-small cell lung cancer cells by regulating the PTEN/PI3K/Akt pathway through down-regulation of miR-18a and miR-21. +lncRNA target 35542211 hsa-mir-155 Acute Kidney Injury The present results suggest that miR-155 inhibitor could be used in an effective targeting strategy for the treatment of acute kidney injury (AKI). +genetics_knock down_promote 35541941 hsa-mir-449a Stomach Neoplasms Furthermore, in vitro knockdown of miR-449a by siRNA significantly inhibited MKN-28 cell proliferation, migration and invasion as well as tumorigenesis via inducing G0/G1 arrest of GC cells. +lncRNA target 35541917 hsa-mir-494 Carcinoma, Hepatocellular Mechanistically, in p53-expressing hepatoma cells, Linc01612 acts as a competitive endogenous RNA and promotes the expression of activation transcription factor 3 (ATF3) by sponging microRNA-494 (miR-494), which in turn inhibits MDM2-mediated ubiquitination of p53 and activates the p53 pathway. +lncRNA target 35541914 hsa-mir-106b Colorectal Neoplasms Then, silencing LINC01559 restored the malignant phenotype of CRC cells, while cotransfection of miR-106b-5p inhibitor neutralized this effect. The results revealed a negative functional regulation of the LINC01559/miR-106b-5p/PTEN axis in CRC progression and explored a new mechanism of METTL3-mediated m6A modification on LINC01559. +other 35541892 hsa-mir-193a Stomach Neoplasms In conclusion, our results illustrated that palmitic acid/p-STAT3/miR-193a-3p/LAMC1 pathway promotes preadipocyte differentiation, pre-metastatic niche formation and gastric cancer cell colonization to peritoneum. +other 35541422 hsa-mir-16 hereditary diffuse gastric cancer Herein, we report a multiplex detection platform based on a suspension array with aggregation-induced emission luminogen (AIEgen) barcodes for simultaneous quantitative measurement of let-7b-5p, miR5p and miR-19b-3p, which are associated with gastric cancer. +other 35541422 hsa-mir-19b hereditary diffuse gastric cancer Herein, we report a multiplex detection platform based on a suspension array with aggregation-induced emission luminogen (AIEgen) barcodes for simultaneous quantitative measurement of let-7b-5p, miR5p and miR-19b-3p, which are associated with gastric cancer. +other 35540851 hsa-mir-122 Myocardial Infarction MicroRNA-122 is associated with the pathogenesis of many cardiovascular diseases, including apoptosis and was found highly increased in our previous rat model of post-myocardial infarction heart failure. +lncRNA target 35540851 hsa-mir-122 Cardiovascular Diseases MicroRNA-122 is associated with the pathogenesis of many cardiovascular diseases, including apoptosis and was found highly increased in our previous rat model of post-myocardial infarction heart failure. We therefore believe that microRNA-122 and Sestrin-2 can be developed as potential therapeutic targets against apoptosis in cardiovascular diseases. +other 35540851 hsa-mir-122 Heart Failure MicroRNA-122 is associated with the pathogenesis of many cardiovascular diseases, including apoptosis and was found highly increased in our previous rat model of post-myocardial infarction heart failure. +other 35540477 hsa-mir-19b late onset Parkinson's disease Background: miR-19b has been reported to be involved in nervous system disease including Parkinson's disease (PD). +other 35540477 hsa-mir-19b Parkinson Disease Background: miR-19b has been reported to be involved in nervous system disease including Parkinson's disease (PD). +other 35540477 hsa-mir-19b Nervous System Diseases Background: miR-19b has been reported to be involved in nervous system disease including Parkinson's disease (PD). +other 35540218 hsa-mir-137 Spinal Cord Injuries Thus, the objective of this study is to determine the role of miRNA (miR)3p during curcumin treatment after SCI. +other 35540209 hsa-mir-137 Colorectal Neoplasms Panax notoginseng saponins radiosensitize colorectal cancer cells by regulating the SNHG6/miR-137 axis. +lncRNA target 35539318 hsa-mir-34a Triple Negative Breast Neoplasms In the present study, nanodiamond (ND), protamine (PS) and folic acid (FA) were used to construct ND-based layer-by-layer nanohybrids through a self-assembly approach for targeted miR-34a delivery in TNBC cells and xenograft TNBC tumors. +transcription factor target 35538494 hsa-mir-3178 Pancreatic Carcinoma These findings suggest that hsa-miR-3178 could be a novel therapeutic target for overcoming gemcitabine resistance in PC. +lncRNA target 35538293 hsa-mir-665 Ischemic Stroke This paper aimed to explore the regulatory mechanism of DEX in ischemic stroke through miR-665/ROCK2 axis. DEX has a protective effect in ischemic stroke by promoting miR-665 expression to downregulate ROCK2/NF-B axis, suggesting DEX has a beneficial effect on ischemic stroke and miR-665 is a conceivable target for the therapeutics and diagnosis of ischemic stroke. +other 35538197 hsa-mir-218 Colorectal Neoplasms 5p/SKAP1 axis. +other 35538149 hsa-mir-6891 Sjogren's Syndrome Moreover, the HLA-locus-expressed miRNA miR6891-5p was decreased in pSS MSCs. pSS MSCs show decreased levels of miR6891-5p, a HLA-expressed miRNA. +target gene 35538053 hsa-mir-494 T-cell acute lymphoblastic leukemia CircFBXW7 inhibits the tumorigenesis of T-cell acute lymphoblastic leukemia through modulating miR-494-3p/SOX1 axis. +lncRNA target 35538030 hsa-mir-1207 Uterine Cervical Neoplasms 5p and inhibits miR +genetics_overexpression_promote 35538027 hsa-mir-545 Ovarian Neoplasms Overexpression of PTP4A1 abrogates the inhibitory function of miR +transcription factor target 35537355 hsa-mir-223 Asthma Taken together, our study suggests that miR3p is a regulator of allergic inflammation and could potentially be used to develop novel and targeted therapy for asthma. +lncRNA target 35537198 hsa-mir-1269 Colorectal Neoplasms HOXC-AS3 directly interacted with miR-1269 in CRC cells. CONCLUSIONS: Upregulation of HOXC-AS3 inhibited TGF-beta2-induced colorectal cancer (CRC) cell migration and invasion possibly by sponging miR-1269. +other 35537095 hsa-mir-181a Alzheimer Disease A recent study has suggested that monitoring a miRNA triad, miR-181a-5p, miR-146a-5p, and miR-148a-3p can identify ACI and its progression to MCI and AD (Islam et al., EMBO Mol Med. +other 35537095 hsa-mir-146a Alzheimer Disease A recent study has suggested that monitoring a miRNA triad, miR-181a-5p, miR-146a-5p, and miR-148a-3p can identify ACI and its progression to MCI and AD (Islam et al., EMBO Mol Med. +other 35537095 hsa-mir-181a Cognitive Dysfunction A recent study has suggested that monitoring a miRNA triad, miR-181a-5p, miR-146a-5p, and miR-148a-3p can identify ACI and its progression to MCI and AD (Islam et al., EMBO Mol Med. +other 35537095 hsa-mir-146a Cognitive Dysfunction A recent study has suggested that monitoring a miRNA triad, miR-181a-5p, miR-146a-5p, and miR-148a-3p can identify ACI and its progression to MCI and AD (Islam et al., EMBO Mol Med. +other 35537095 hsa-mir-148a Alzheimer Disease A recent study has suggested that monitoring a miRNA triad, miR-181a-5p, miR-146a-5p, and miR-148a-3p can identify ACI and its progression to MCI and AD (Islam et al., EMBO Mol Med. +other 35537095 hsa-mir-148a Cognitive Dysfunction A recent study has suggested that monitoring a miRNA triad, miR-181a-5p, miR-146a-5p, and miR-148a-3p can identify ACI and its progression to MCI and AD (Islam et al., EMBO Mol Med. +other 35536760 hsa-mir-10b Multiple Myeloma Finally, we revealed the consistently deregulated expression level of key gene CDKN2A and its co-regulatory DEmiRs, including hsa-mir-192, hsa-mir-10b, hsa-mir-492, and hsa-mir-24 in the independent cohorts of MM. +other 35536760 hsa-mir-192 Multiple Myeloma Finally, we revealed the consistently deregulated expression level of key gene CDKN2A and its co-regulatory DEmiRs, including hsa-mir-192, hsa-mir-10b, hsa-mir-492, and hsa-mir-24 in the independent cohorts of MM. +other 35536760 hsa-mir-492 Multiple Myeloma Finally, we revealed the consistently deregulated expression level of key gene CDKN2A and its co-regulatory DEmiRs, including hsa-mir-192, hsa-mir-10b, hsa-mir-492, and hsa-mir-24 in the independent cohorts of MM. +other 35536760 hsa-mir-24 Multiple Myeloma Finally, we revealed the consistently deregulated expression level of key gene CDKN2A and its co-regulatory DEmiRs, including hsa-mir-192, hsa-mir-10b, hsa-mir-492, and hsa-mir-24 in the independent cohorts of MM. +transcription factor target 35536531 hsa-mir-425 Arthritis, Rheumatoid Overall, Tofacitinib exerted inhibitory effect on proliferation and inflammation of RA-FLS through modulating STAT6/miR +other 35536524 hsa-mir-17 Leukemia, Myeloid, Acute CONCLUSIONS: High expression of miR-17 in de novo AML patients pointed to dismal clinical outcome and disease recurrence, which could serve as novel prognostic biomarker for AML patients. +genetics_knock down_promote 35536149 hsa-mir-16 Colorectal Neoplasms 5p overexpression or FOXK1 knockdown reduced CRC cell proliferation and angiogenesis of human umbilical vein endothelial cells co-cultured with the supernatant of CRC cells, whereas miR +genetics_overexpression_suppress 35536095 hsa-mir-30 Osteoarthritis 5p depletion and FSHR overexpression diminished the effects of silencing LINC00707 in OA progression. +other 35536066 hsa-mir-488 Venous Thrombosis miR-488 combined with SIRT1 has a high predictive value for the occurrence of DVT. +other 35535987 hsa-mir-335 Multiple Myeloma CircKCNQ5 controls proliferation, migration, invasion, apoptosis, and glycolysis of multiple myeloma cells by modulating miR-335-5p/BRD4 axis. +lncRNA target 35535903 hsa-mir-24 Brain Ischemia 3p reduces ischemic brain damage via the GATA2/A1R axis. +genetics_overexpression_promote 35535453 hsa-mir-367 Breast Neoplasms Therefore, we aimed to investigate whether overexpression of miR-302/367 cluster and aspirin treatment cooperate in the induction of reprogramming and tumor suppression in breast cancer cells. +other 35535387 hsa-mir-577 Heart Valve Diseases These phenomena may result from hsa_circ_0003748 promoting RVHD after sponging miR-577. +circRNA target 35535385 hsa-mir-1278 Stomach Neoplasms MiR-1278 targeted FN1, and silencing FN1 neutralized the effects of miR-1278 inhibitors on GC progression. +genetics_GWAS 35535334 hsa-mir-146a Environmental Illness This is the first study reporting that miR146a rs57095329 A/G, rs2961920A/C, and rs6864584 T/C polymorphisms are associated with the risk of IRSM in a southern Iranian population. +lncRNA target 35534923 hsa-mir-3 Atherosclerosis CONCLUSIONS: This study provides proof of principle for the application of pHLIP for treating advanced atherosclerosis via pharmacological inhibition of miR-33 in macrophages that avoid the deleterious effects in other metabolic tissues. +other 35534828 hsa-mir-20a Diabetes Mellitus, Type 1 The ROC curves showed that ADM (0.9375), RRAGD (0.8958), and hsa-mir-320a (0.9417) had high accuracy in T1D diagnosis. CONCLUSION: The constructed regulatory networks, including miR-320a/ADM/SOX5 and miR-320a/RRAGD/SOX5, may provide new insight into the mechanisms of development and progression in T1D. +lncRNA target 35533989 hsa-mir-1249 Influenza, Human 5p played an important role in ALI, and further investigation of its target gene SLC4A1 and NF-kappaB signaling pathway provides ideas for new therapeutic targets and strategies for ALI. +lncRNA target 35533989 hsa-mir-1249 Acute Lung Injury 5p played an important role in ALI, and further investigation of its target gene SLC4A1 and NF-kappaB signaling pathway provides ideas for new therapeutic targets and strategies for ALI. +lncRNA target 35533615 hsa-mir-526b Uterine Cervical Neoplasms Hsa_circ_0001495/miR-526b-3p/TMBIM6 axis also regulated the phosphorylation of mammalian target of rapamycin (mTOR) in CC cells. +other 35533171 hsa-mir-145 Multiple Sclerosis Therefore, an ultrasensitive optical biosensor based on hybridization chain reaction (HCR) was developed to detect microRNA-145 (miRNA-145) as an MS biomarker. +lncRNA target 35533015 hsa-mir-375 Fatty Liver In this study, the differentially expressed miR-375 as well as its target gene MAP3K1 (mitogen-activated protein kinase kinase kinase 1) were screened out by interaction network analysis of microRNA sequencing results and transcriptome profiling in the fatty liver group of the F0-F3 generation (p < 0.05 or p < 0.01). +other 35532940 hsa-mir-122 Alzheimer Disease 5p were differentially expressed compared with CN or PD. +other 35532940 hsa-mir-210 Alzheimer Disease 5p were differentially expressed compared with CN or PD. +lncRNA target 35532870 hsa-mir-99a Uterine Cervical Neoplasms In addition, cellular experiments including CCK8, wound healing, Transwell and flow cytometry assays disclosed that transfection of miR-99a-5p mimic could suppress the cell activity, cell migratory, and invasive abilities, and promote cell apoptosis, thus inhibiting the tumor progression of CSCC cells. +other 35532548 hsa-mir-20a Osteoporosis ddPCR validation confirmed lower c-miR-23a-3p expression in osteoporotic patients, with or without fracture, than in osteopenic and normal subjects and increased c-miR-320a-3p expression in osteoporotic patients with fracture and lower expression in osteoporotic patients without fracture. Increased levels of c-miR-320a-3p specifically associated with fractures, independently by BMD, suggesting c-miR-320a-3p as a prognostic indicator of fracture risk in osteoporotic patients, to be confirmed in prospective studies on incident fractures. +other 35532548 hsa-mir-23a Osteoporosis ddPCR validation confirmed lower c-miR-23a-3p expression in osteoporotic patients, with or without fracture, than in osteopenic and normal subjects and increased c-miR-320a-3p expression in osteoporotic patients with fracture and lower expression in osteoporotic patients without fracture. +other 35532548 hsa-mir-20a Fractures, Bone ddPCR validation confirmed lower c-miR-23a-3p expression in osteoporotic patients, with or without fracture, than in osteopenic and normal subjects and increased c-miR-320a-3p expression in osteoporotic patients with fracture and lower expression in osteoporotic patients without fracture. Increased levels of c-miR-320a-3p specifically associated with fractures, independently by BMD, suggesting c-miR-320a-3p as a prognostic indicator of fracture risk in osteoporotic patients, to be confirmed in prospective studies on incident fractures. +other 35532548 hsa-mir-23a Fractures, Bone ddPCR validation confirmed lower c-miR-23a-3p expression in osteoporotic patients, with or without fracture, than in osteopenic and normal subjects and increased c-miR-320a-3p expression in osteoporotic patients with fracture and lower expression in osteoporotic patients without fracture. +lncRNA target 35532539 hsa-mir-375 Prostatic Neoplasms miR-375 mimic could partially reverse the inhibitory effects of sh-BACH1 on the proliferation, invasion, and migration of isoflurane-treated PC cells. +circRNA target 35532376 hsa-mir-139 Ischemic Stroke In summary, we reveal for the first time that circUSP36 attenuates ischemic stroke injury through the miR3p/SMAD3/Bcl2 signal axis, which make circUSP36 a potential therapeutic target for IS. +other 35532294 hsa-mir-27a Carcinoma, Hepatocellular The oncogenic miR-27a/BTG2 axis promotes obesity-associated hepatocellular carcinoma by mediating mitochondrial dysfunction. +circRNA target 35532261 hsa-mir-223 Stomach Neoplasms Importantly, ICA inhibited GC cell viability and triggered GC cell pyroptosis by regulating the hsa_circ_0003159/miR +other 35532186 hsa-mir-21 Hepatoblastoma For the prognostic analysis of miRNAs in HB, the abnormal expressions of miR-21, miR-34a, miR-34b, miR-34c, miR-492, miR-193, miR-222, and miR-224 in patients were confirmed to be associated with a worse prognosis. +other 35532186 hsa-mir-34a Hepatoblastoma For the prognostic analysis of miRNAs in HB, the abnormal expressions of miR-21, miR-34a, miR-34b, miR-34c, miR-492, miR-193, miR-222, and miR-224 in patients were confirmed to be associated with a worse prognosis. +other 35532186 hsa-mir-34c Hepatoblastoma For the prognostic analysis of miRNAs in HB, the abnormal expressions of miR-21, miR-34a, miR-34b, miR-34c, miR-492, miR-193, miR-222, and miR-224 in patients were confirmed to be associated with a worse prognosis. +other 35532186 hsa-mir-34b Hepatoblastoma For the prognostic analysis of miRNAs in HB, the abnormal expressions of miR-21, miR-34a, miR-34b, miR-34c, miR-492, miR-193, miR-222, and miR-224 in patients were confirmed to be associated with a worse prognosis. +genetics_overexpression_suppress 35532178 hsa-mir-205 Bulimia Nervosa Consistently, miR-205 was found to be overexpressed in human BCs, and ectopic expression of miR-205 mitigated ISO inhibitory effects against EGF-induced outcomes. +transcription factor target 35532075 hsa-mir-149 Endotoxemia Collectively, resveratrol upregulated miR-149, downregulated HMGB1, and inhibited the ferroptosis pathway, thus improving cardiomyocyte injury in LPS-induced endotoxemia.NEW & NOTEWORTHY Sepsis is an unusual systemic reaction. This study explored the mechanism of resveratrol in sepsis by regulating the miR-149/HMGB1 axis. +other 35532070 hsa-mir-194 Kidney Diseases 5p in both age groups. +other 35532070 hsa-mir-24 Nephrosclerosis 5p in both age groups. +other 35532070 hsa-mir-194 familial febrile seizures 1 5p in both age groups. +other 35532070 hsa-mir-20a Nephrosclerosis 5p in both age groups. +other 35532070 hsa-mir-24 familial febrile seizures 1 5p in both age groups. +other 35532070 hsa-mir-20a Kidney Diseases 5p in both age groups. +other 35532070 hsa-mir-194 Nephrosclerosis 5p in both age groups. +other 35532070 hsa-mir-24 Kidney Diseases 5p in both age groups. +other 35532070 hsa-mir-20a familial febrile seizures 1 5p in both age groups. +genetics_overexpression_promote 35531876 hsa-mir-146 Ovarian Insufficiency, Premature In summary, we reveal the up-regulation of miRNA-146 expression mitigated ovarian dysfunction by negatively regulating expression of the IL-6 and TNF-a, which may shed light on the potential molecular mechanisms of overexpression of miRNA-146 may reversed the ovarian dysfunction by inhibiting the TLR4/ NF-kappaB signaling pathway. +lncRNA target 35531688 hsa-mir-148 Liver Cirrhosis mediated NLRP3 inflammasome by the negative feedback of the suppressor of cytokine signaling-1(SOCS-1), miR-181 a-mediated downstream NLRP3 inflammatory pathway activation through mitogen-activated protein kinase kinase(MEK)/extracellular signal-regulated kinase(ERK)/nuclear transcription factor kappaB(NF-kappaB) inflammatory pathway, miR +lncRNA target 35531688 hsa-mir-181 Liver Cirrhosis mediated NLRP3 inflammasome by the negative feedback of the suppressor of cytokine signaling-1(SOCS-1), miR-181 a-mediated downstream NLRP3 inflammatory pathway activation through mitogen-activated protein kinase kinase(MEK)/extracellular signal-regulated kinase(ERK)/nuclear transcription factor kappaB(NF-kappaB) inflammatory pathway, miR +lncRNA target 35531688 hsa-mir-350 Liver Cirrhosis mediated NLRP3 inflammasome by the negative feedback of the suppressor of cytokine signaling-1(SOCS-1), miR-181 a-mediated downstream NLRP3 inflammatory pathway activation through mitogen-activated protein kinase kinase(MEK)/extracellular signal-regulated kinase(ERK)/nuclear transcription factor kappaB(NF-kappaB) inflammatory pathway, miR +lncRNA target 35531688 hsa-mir-20 Liver Cirrhosis mediated NLRP3 inflammasome by the negative feedback of the suppressor of cytokine signaling-1(SOCS-1), miR-181 a-mediated downstream NLRP3 inflammatory pathway activation through mitogen-activated protein kinase kinase(MEK)/extracellular signal-regulated kinase(ERK)/nuclear transcription factor kappaB(NF-kappaB) inflammatory pathway, miR +lncRNA target 35531688 hsa-mir-21 Liver Cirrhosis mediated NLRP3 inflammasome by the negative feedback of the suppressor of cytokine signaling-1(SOCS-1), miR-181 a-mediated downstream NLRP3 inflammatory pathway activation through mitogen-activated protein kinase kinase(MEK)/extracellular signal-regulated kinase(ERK)/nuclear transcription factor kappaB(NF-kappaB) inflammatory pathway, miR +lncRNA target 35531688 hsa-mir-155 Liver Cirrhosis mediated NLRP3 inflammasome by the negative feedback of the suppressor of cytokine signaling-1(SOCS-1), miR-181 a-mediated downstream NLRP3 inflammatory pathway activation through mitogen-activated protein kinase kinase(MEK)/extracellular signal-regulated kinase(ERK)/nuclear transcription factor kappaB(NF-kappaB) inflammatory pathway, miR +circulation_biomarker_diagnosis_ns 35531134 hsa-mir-33a Diabetes Mellitus The objective of the present study was to investigate the relationship between miR-33a, miR-122, erythrocyte membrane fatty acids profile, and serum lipids with components of metabolic syndrome in an Iranian population suffering from type 2 diabetes mellitus (T2DM). +circulation_biomarker_diagnosis_ns 35531134 hsa-mir-33a Diabetes Mellitus, Type 2 The objective of the present study was to investigate the relationship between miR-33a, miR-122, erythrocyte membrane fatty acids profile, and serum lipids with components of metabolic syndrome in an Iranian population suffering from type 2 diabetes mellitus (T2DM). +circulation_biomarker_diagnosis_ns 35531134 hsa-mir-122 Diabetes Mellitus The objective of the present study was to investigate the relationship between miR-33a, miR-122, erythrocyte membrane fatty acids profile, and serum lipids with components of metabolic syndrome in an Iranian population suffering from type 2 diabetes mellitus (T2DM). +circulation_biomarker_diagnosis_ns 35531134 hsa-mir-122 Diabetes Mellitus, Type 2 The objective of the present study was to investigate the relationship between miR-33a, miR-122, erythrocyte membrane fatty acids profile, and serum lipids with components of metabolic syndrome in an Iranian population suffering from type 2 diabetes mellitus (T2DM). +transcription factor target 35530951 hsa-mir-21 Colitis Intravenous injection of miR-21 antagonists can effectively relieve the symptoms of colitis and inhibit colonic angiogenesis. +circulation_biomarker_diagnosis_ns 35530650 hsa-mir-1247 Pancreatic Diseases RESULTS: The methylation rate of miR-1247 was significantly higher in patients with BTC than in those with BD, and tended to be higher in patients with PC than in those with BD. CONCLUSION: Methylation of miR-1247 in plasma may be useful to distinguish BTC from BD. +lncRNA target 35530496 hsa-mir-195 Leukemia, Myeloid, Acute Conclusion: Our data indicated that ZFAS1 silencing alleviated ADR resistance of AML cells in vitro through acting as a sponge for miR-195 and regulating Myb expression. +circRNA target 35530358 hsa-mir-1263 Carcinoma, Hepatocellular Mechanistic investigations revealed that circERBIN regulated HCC proliferation by acting as a sponge of miR-1263, which subsequently targeted cyclin dependent kinase 6 and controlled G1/S transition. +genetics_overexpression_promote 35530352 hsa-mir-29b Thyroid Cancer, Papillary Functional assays revealed that overexpression of COL1A1 or COL5A1 reversed the suppressive role of miR-29b-3p in migration, invasion, and EMT of PTC cells. +transcription factor target 35529491 hsa-mir-9 Muscular Diseases In conclusion, the miR5p/Dlx3/Myf5 axis is a novel pathway for the regulation of myogenic differentiation, and can be a potential target to treat the diseases related to muscle dysfunction. +lncRNA target 35529258 hsa-mir-138 Hemangioma, Infantile CONCLUSION: Hsa_circ_0003570 promotes IH cell proliferation and inhibits IH cell apoptosis through hsa-miR5p/RGS5 axis. +other 35529221 hsa-mir-205 Nasopharyngeal Carcinoma Since microRNA-205 (miR-205) is a predictive biomarker for anti-radiation of nasopharyngeal carcinoma (NPC), quantitative detection of miR-205 is important for developing personalized strategies for the treatment of NPC. +target gene 35528911 hsa-mir-141 Osteosarcoma Long non-coding RNA DLX6-AS1/miR-141-3p axis regulates osteosarcoma proliferation, migration and invasion through regulating Rab10. +transcription factor target 35528843 hsa-mir-21 Sepsis CONCLUSIONS: The differentiation and function of Th17/Treg cells were regulated by miR-21 in sepsis through caspase pathway. +circulation_biomarker_diagnosis_ns 35528840 hsa-mir-181b Diabetic Foot Several datasets suggest that miR-181b-5p expression might be enriched in exosomes from DFU; this was verified using quantitative real-time PCR (qRT-PCR). In conclusion, this study indicated that circulating exosomal miR-181b-5p promoted cell senescence and inhibited angiogenesis to impair wound healing in DFU by regulating the NRF2/HO-1 pathway. +other 35528830 hsa-mir-451 Acute Lung Injury RESULTS: LPS significantly increased lung inflammation, neutrophil infiltration, and oxidative stress and downregulated lung miR-451 expression. +other 35528669 hsa-mir-107 Alzheimer Disease Berberine protected against Abeta(25-35)-induced inflammatory injury, apoptosis and phosphorylation of tau by regulating miR-107 and ZNF217, indicating berberine as a promising neuroprotective agent for therapeutics of AD. +genetics_overexpression_suppress 35528616 hsa-mir-615 Carcinoma, Hepatocellular CONCLUSION: HAO2 was found to be underexpressed in HCC tissues and cells, and HAO2 overexpression inhibited HCC cell motility, which was negatively regulated by miR +circulation_biomarker_diagnosis_ns 35528582 hsa-mir-16 Arthritis, Rheumatoid In this study, we firstly examined the miR-16 expression in the serum and synovial fluid from RA patients who were unresponsive to methotrexate monotherapy (UR-MTX patients) and responsive RA patients (R-MTX patients). +circulation_biomarker_diagnosis_up 35528582 hsa-mir-16 Uremia In this study, we firstly examined the miR-16 expression in the serum and synovial fluid from RA patients who were unresponsive to methotrexate monotherapy (UR-MTX patients) and responsive RA patients (R-MTX patients). MiR-16 was upregulated in the in serum and synovial fluid from UR-MTX patients as well as in FLS-MTX cells. +other 35528544 hsa-mir-6088 Neurodegenerative Diseases Finally, the link between candidate miRNA features, including hsa-miR5p, has-miR-6088, and has-miR-4649, and neurodegenerative diseases was confirmed using recently published research, laying the groundwork for more research on miRNAs in neurodegenerative diseases for the diagnosis of cognitive impairment and the understanding of potential pathogenic mechanisms. +other 35528544 hsa-mir-184 Neurodegenerative Diseases Finally, the link between candidate miRNA features, including hsa-miR5p, has-miR-6088, and has-miR-4649, and neurodegenerative diseases was confirmed using recently published research, laying the groundwork for more research on miRNAs in neurodegenerative diseases for the diagnosis of cognitive impairment and the understanding of potential pathogenic mechanisms. +other 35528544 hsa-mir-4649 Neurodegenerative Diseases Finally, the link between candidate miRNA features, including hsa-miR5p, has-miR-6088, and has-miR-4649, and neurodegenerative diseases was confirmed using recently published research, laying the groundwork for more research on miRNAs in neurodegenerative diseases for the diagnosis of cognitive impairment and the understanding of potential pathogenic mechanisms. +exosome 35528244 hsa-mir-6838 Thyroid Neoplasms These results suggest that FGD5-AS1 in tumor-derived exoskeleton promotes angiogenesis, vascular permeability, and metastasis by regulating the endothelial miR5p/VAV2 axis and ultimately promotes the occurrence and development of TC. +other 35527788 hsa-let-7b Colorectal Neoplasms hsa_circ_0000523/miR-let-7b/METTL3 axis regulates proliferation, apoptosis and metastasis in the HCT116 human colorectal cancer cell line. +lncRNA target 35527652 hsa-mir-125b Rhinitis, Allergic CONCLUSION: lnc-THRIL and its target (miR-125b) relate to disease risk, symptom severity, and Th1/Th2 imbalance of AR, suggesting their potential as biomarkers for AR management. +other 35527543 hsa-mir-758 Atherosclerosis CONCLUSION: Circ_0093887 demonstrated its diagnostic and therapeutic value in AS by promoting the role of the miR3p/BAMBI axis in the ox-LDL-induced endothelial injury of HAECs. +lncRNA target 35527493 hsa-mir-20a Lung Neoplasms [miR-20a-5p inhibits proliferation of lung cancer A549 cells by down-regulating OBJECTIVE: To investigate the molecular mechanism by which miR-20a-5p regulates HOXB13 gene expression and inhibits lung cancer cell proliferation. CONCLUSION: miR-20a-5p inhibits proliferation of lung cancer cells by down-regulating the expression of HOXB13. +circulation_biomarker_diagnosis_up 35527417 hsa-mir-106b Thrombocytopenia The correlation analysis showed that in the children with ITP, the expression level of plasma miR-106b-5p was positively correlated with the Th17 level and the Th17/Treg ratio (r=0.730 and 0.816 respectively; P<0.001) and was negatively correlated with the Treg level (r=-0.774, P<0.001). +transcription factor target 35527277 hsa-mir-504 Alzheimer Disease CONCLUSIONS: Our results suggest for the first time that melatonin alleviates tau-related pathologies through upregulation of miR3p expression by targeting the p39/CDK5 axis and provide novel insights into AD treatment strategies. +transcription factor target 35527005 hsa-mir-34a Liver Injury Collectively, DEX could alleviate acute stress-induced liver injury through ROS/JNK/p38 signaling pathway via downregulation of miR-34a-5p. +other 35526722 hsa-mir-665 Osteoarthritis CONCLUSION: Our findings unraveled that circ_0136474 promoted chondrocyte injury in IL-1beta-induced OA model by depending on the regulation of miR-665/FGFR1 axis. +circRNA target 35525959 hsa-mir-181a Adenocarcinoma of Lung Mechanistically, circHMGB2 relieves the inhibition of downstream CARM1 by sponging miR-181a-5p, thus inactivating the type 1 interferon response in the LUAD and LUSC. +other 35525840 hsa-mir-10b Glioblastoma MiR-34a might be considered as a predictive factor for toxicity due to its changes during treatment, and differences between the groups with and without toxicity; miR-10b might be used to predict toxicity; miR-10b/21 might be used for predicting the grade of toxicity in GB patients. +other 35525840 hsa-mir-34a Glioblastoma MiR-34a might be considered as a predictive factor for toxicity due to its changes during treatment, and differences between the groups with and without toxicity; miR-10b might be used to predict toxicity; miR-10b/21 might be used for predicting the grade of toxicity in GB patients. +circulation_biomarker_diagnosis_ns 35525722 hsa-mir-124 Carcinoma, Hepatocellular AIMS: To correlate miRNA-29a and miRNA-124 expression levels with the clinical features and survival rates of HCC patients. RESULTS: The expression levels of serum miRNA-29a were higher and the levels of miRNA-124 were lower in patients with HCC than in patients with liver cirrhosis and controls. +circulation_biomarker_diagnosis_ns 35525722 hsa-mir-29a Carcinoma, Hepatocellular AIMS: To correlate miRNA-29a and miRNA-124 expression levels with the clinical features and survival rates of HCC patients. RESULTS: The expression levels of serum miRNA-29a were higher and the levels of miRNA-124 were lower in patients with HCC than in patients with liver cirrhosis and controls. +other 35524996 hsa-let-7a Schizophrenia 5p/let-7a-5p-IL6 networks in course of the treatment of SZ. +other 35524996 hsa-mir-155 Schizophrenia 5p/let-7a-5p-IL6 networks in course of the treatment of SZ. +other 35524977 hsa-mir-873 Cardiomyopathies To conclude, TDRG1 aggravates DCM progression by binding with miR5p to upregulate PRKAR2. +transcription factor target 35524907 hsa-mir-133a Cardiotoxicity The data suggest that miR-133a is associated with DOX-based cardiotoxicity during chemotherapy in breast cancer patients through ErbB2 signaling pathway. Moreover, miR-133a may be a future marker of DOX-induced cardiotoxicity in women with breast cancer. +transcription factor target 35524907 hsa-mir-133a Breast Neoplasms The data suggest that miR-133a is associated with DOX-based cardiotoxicity during chemotherapy in breast cancer patients through ErbB2 signaling pathway. Moreover, miR-133a may be a future marker of DOX-induced cardiotoxicity in women with breast cancer. +genetics_knock down_promote 35524876 hsa-mir-181a Ovarian Neoplasms The results reveal the knockdown of LINC00665 facilitates ovarian cancer via development by sponging miR-181a-5p and up-regulating FHDC1 expression. +genetics_GWAS 35524830 hsa-mir-17 Hepatitis C 3p, and TLR2 - 196 to - 174 del/ins polymorphisms from the blood/serum of 34 hepatitis C virus (HCV)-infected patients pre- and post-ombitavir/paritaprevir/ritonavir+dasabuvir treatment were determined by RT-qPCR. +genetics_GWAS 35524830 hsa-mir-24 Hepatitis C 3p, and TLR2 - 196 to - 174 del/ins polymorphisms from the blood/serum of 34 hepatitis C virus (HCV)-infected patients pre- and post-ombitavir/paritaprevir/ritonavir+dasabuvir treatment were determined by RT-qPCR. +genetics_GWAS 35524830 hsa-mir-223 Hepatitis C 3p, and TLR2 - 196 to - 174 del/ins polymorphisms from the blood/serum of 34 hepatitis C virus (HCV)-infected patients pre- and post-ombitavir/paritaprevir/ritonavir+dasabuvir treatment were determined by RT-qPCR. +other 35524480 hsa-mir-125a Inflammatory Bowel Diseases CONCLUSION: Dioscin modulated macrophage polarization by increasing miR-125a-5p, thereby improving the intestinal epithelial barrier function and reducing IBD. +other 35524422 hsa-mir-203a Thyroid Cancer, Papillary In PTC, the role of miR-203a-3p and the underlying mechanisms remain not completely understood. RESULTS: We found that the levels of miRNA-203a-3p were statistically decreased in PTC tissues. +other 35524416 hsa-mir-137 Gout The research indicates that five miRNAs (miR-429, miR-137, miR5p, miR-217, miR-23b-3p) and five lncRNAs (SNHG1, FAM182A, SPAG5-AS1, HNF1A-AS1, UCA1) play an important role in the formation and development of gout. +other 35524416 hsa-mir-23b Gout The research indicates that five miRNAs (miR-429, miR-137, miR5p, miR-217, miR-23b-3p) and five lncRNAs (SNHG1, FAM182A, SPAG5-AS1, HNF1A-AS1, UCA1) play an important role in the formation and development of gout. +other 35524416 hsa-mir-217 Gout The research indicates that five miRNAs (miR-429, miR-137, miR5p, miR-217, miR-23b-3p) and five lncRNAs (SNHG1, FAM182A, SPAG5-AS1, HNF1A-AS1, UCA1) play an important role in the formation and development of gout. +other 35524416 hsa-mir-139 Gout The research indicates that five miRNAs (miR-429, miR-137, miR5p, miR-217, miR-23b-3p) and five lncRNAs (SNHG1, FAM182A, SPAG5-AS1, HNF1A-AS1, UCA1) play an important role in the formation and development of gout. +other 35524416 hsa-mir-429 Gout The research indicates that five miRNAs (miR-429, miR-137, miR5p, miR-217, miR-23b-3p) and five lncRNAs (SNHG1, FAM182A, SPAG5-AS1, HNF1A-AS1, UCA1) play an important role in the formation and development of gout. +circulation_biomarker_diagnosis_down 35524373 hsa-mir-155 Breast Neoplasms The expression rate of miR-155 and its downstream target gene, SOCS-1, as well as the plasma levels of IL-6, were evaluated in peripheral blood mononuclear cells of NDBC patients; using real-time PCR and enzyme-linked immunosorbent assay, respectively. +circRNA target 35524319 hsa-mir-346 Carcinoma, Hepatocellular CONCLUSIONS: CircMDK could serve as a potential tumor biomarker that promotes the progression of HCC via the miR-346/874-3p-ATG16L1 axis. +circRNA target 35524319 hsa-mir-874 Carcinoma, Hepatocellular CONCLUSIONS: CircMDK could serve as a potential tumor biomarker that promotes the progression of HCC via the miR-346/874-3p-ATG16L1 axis. +lncRNA target 35524230 hsa-mir-17 Teratoid Rhabdoid Tumor, Atypical 5p may be a pivotal event in AT/RT and miRNAs that may represent potential therapeutic targets and diagnostic biomarkers. +other 35524161 hsa-mir-383 Esophageal Squamous Cell Carcinoma 5p to promote ESCC progression by upregulating KIAA0101, which provided a potential therapeutic strategy for ESCC treatment. +other 35523949 hsa-mir-513a Lupus Nephritis Our findings indicated that circRTN4 exacerbates mesangial cell dysfunction by activating the miR-513a-5p/FN axis in lupus nephritis. +other 35523945 hsa-mir-128 Angelman Syndrome Our study demonstrates that LSS could regulate the expression of EPHB2 in HAECs, and the LOC107986345/miR3p/EPHB2 axis plays a vital role in AS development. +lncRNA target 35523945 hsa-mir-128 Leigh Disease Further research revealed the anti-inflammatory effect of LSS depends on autophagy activation resulting from the nuclear translocation of HMGB1 via the LOC107986345/miR +circulation_biomarker_diagnosis_up 35522909 hsa-mir-769 Stomach Neoplasms 5p was upregulated in GC tissues and enriched in the serum exosomes of cisplatin-resistant patients. +lncRNA target 35522362 hsa-mir-1294 Esophageal Squamous Cell Carcinoma circ_0023984 facilitates the malignant biological behaviors of ESCC cells through inhibiting miR-1294 and activating PI3K/Akt/c-myc pathway. +other 35522176 hsa-mir-20a Atherosclerosis MiR-320a was highly expressed, whereas RGS5 showed low levels of expression in the arterial plaque tissues. +other 35521936 hsa-mir-217 Head and Neck Neoplasms In addition, copy number alterations (CNAs) of INHBA and miR5p downregulation are potential mechanisms for elevated INHBA expression in HNSC. +genetics_GWAS 35521898 hsa-mir-485 Adenocarcinoma of Lung 3p-NEK4 axis might halt the tumor-inhibiting role of propofol in LUAD cells in vitro, suggesting a potential epigenetic pathway of propofol. +circulation_biomarker_diagnosis_ns 35521768 hsa-mir-146b Thyroid Neoplasms Among the six candidates, only miR-146b-5p and miR-21a-5p displayed a significant differential abundance in purified plasma-derived EVs from patients with PTC and benign disease. +circulation_biomarker_diagnosis_ns 35521768 hsa-mir-21 Thyroid Neoplasms Among the six candidates, only miR-146b-5p and miR-21a-5p displayed a significant differential abundance in purified plasma-derived EVs from patients with PTC and benign disease. +lncRNA target 35521747 hsa-mir-6509 Stomach Neoplasms Together, lncRNA HOXA10-AS potentially acted as an oncogene through the lncRNA HOXA10-AS/miR +other 35521691 hsa-mir-4715 Non-alcoholic Fatty Liver Disease The miR3p/GSDMD axis potentially modulates macrophage-associated immunity and indicates fibrosis progression in NAFLD. +other 35521691 hsa-mir-4715 Diabetic Nephropathies The miR3p/GSDMD axis potentially modulates macrophage-associated immunity and indicates fibrosis progression in NAFLD. +target gene 35521597 hsa-mir-425 Triple Negative Breast Neoplasms miR-425 suppresses EMT and the development of TNBC (triple-negative breast cancer) by targeting the TGF-β 1/SMAD 3 signaling pathway. +genetics_knock down_promote 35520918 hsa-mir-148b Leukemia, Myeloid, Acute Moreover, HOTAIRM1 knockdown inhibited proliferation and induced apoptosis in AML cells by negatively regulating miR-148b. +genetics_knock down_promote 35520918 hsa-mir-148 Leukemia, Myeloid, Acute Moreover, HOTAIRM1 knockdown inhibited proliferation and induced apoptosis in AML cells by negatively regulating miR-148b. +genetics_knock down_promote 35520918 hsa-mir-148a Leukemia, Myeloid, Acute Moreover, HOTAIRM1 knockdown inhibited proliferation and induced apoptosis in AML cells by negatively regulating miR-148b. +genetics_knock down_suppress 35520785 hsa-mir-126 Thyroid Cancer, Papillary Conclusion: CircPVT1 knockdown inhibited PTC progression by sponging miR-126. +circulation_biomarker_diagnosis_up 35519896 hsa-mir-486 Sepsis Our data supported that miR-486 was upregulated in the serum of sepsis patients. +target gene 35519367 hsa-let-7d Pulmonary Fibrosis miR-let-7d attenuates EMT by targeting HMGA2 in silica-induced pulmonary fibrosis. +target gene 35519332 hsa-mir-185 Colorectal Neoplasms Long non coding RNA UCA1 contributes to the autophagy and survival of colorectal cancer cells via sponging miR-185-5p to up-regulate the WISP2/β-catenin pathway. +target gene 35518787 hsa-mir-21 Carcinoma, Hepatocellular JPHYD Inhibits miR-21-5p/Smad7-Mediated Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma Cells. +lncRNA target 35517895 hsa-mir-122 non-alcoholic steatohepatitis Conclusion: trans-Chalcone could inhibit the transition from steatosis to NASH through the modulation of miR-122, 21, 34a, and 451 expression levels in the liver. +target gene 35517889 hsa-mir-193a Stomach Neoplasms microRNA-193a-5p Suppresses the Migratory Ability of Human KATO III Gastric Cancer Cells through Inhibition of Vimentin and MMP-9. +target gene 35517885 hsa-mir-143 Stomach Neoplasms Restoration of miRNA-143 Expression Inhibits Growth and Migration of MKN-45 Gastric Cancer Cell Line. +other 35517862 hsa-mir-335 Colonic Neoplasms Five hub genes co-expressed with SLC7A11 that induce ferroptosis were identified, and mir5p, RELA, and securinine have regulatory effects on it. +other 35517418 hsa-mir-1247 Adenocarcinoma of Lung Conclusions: miR3p acted as a potential governor monitoring cell migration and chemotherapy resistance of LUAD by interacting with STAT5A. +target gene 35517414 hsa-mir-4723 Pancreatic Neoplasms CAV2 Regulates Mir-4723/Wnt7A Signalling Axis through Endocytosis and Epithelial-Mesenchymal Transition to Promote Proliferation, Invasion, and Metastasis of Pancreatic Cancer Cells. +lncRNA target 35517408 hsa-mir-199a Carcinoma, Non-Small-Cell Lung The data suggests that miR-199a-5p can inhibit glucose metabolism in NSCLC by targeting SLC2A1.This study proves that miR-199a-5p / SLC2A1 can play an essential role in the development of NSCLC by targeting SLC2A1. +lncRNA target 35517406 hsa-mir-873 Glioma Moreover, WZY-321 treatment decreased miR-873 expression and increased lncRNA MTM expression in glioma cells, and down-regulated miR-873 or up-regulated MTM lead to glioma cell apoptosis. Taken together, these data indicate that WZY-321 triggers glioma cell apoptosis via XAF1 up-regulation caused by MTM-mediated miR-873 down-regulation. +lncRNA target 35516861 hsa-mir-377 Melanoma 3p suppressed melanoma cell growth partly mediated via the ARMC8 expression. +other 35516838 hsa-mir-210 Skeletal Muscular Injury, Non-Ischemic The increase in hif1alpha level was observed just after the muscular injury in this non-ischemic tissue injury model, and the elevation in microRNA-210 level was noted at the initiation of tissue regeneration, indicating its effects on tissue protection and repair. +lncRNA target 35516319 hsa-mir-34a Angelman Syndrome Conclusion: Metformin facilitated proliferation and inhibited apoptosis of macrophages treated with Ox-LDL through the miR-34a/Bcl2 axis, indicating the potential value of metformin in AS therapy. +lncRNA target 35515212 hsa-mir-346 Stomach Neoplasms Collectively, circSMARCA5 exhibited a tumor suppressor-like activity in gastric cancer via regulating the miR-346/FBXL2 axis. +genetics_overexpression_promote 35514986 hsa-mir-582 Precursor Cell Lymphoblastic Leukemia-Lymphoma overexpressing BCP-ALL cells. +target gene 35514612 hsa-mir-124 Carcinoma, Non-Small-Cell Lung miR-124 and miR-142 enhance cisplatin sensitivity of non-small cell lung cancer cells through repressing autophagy via directly targeting SIRT1. +target gene 35514612 hsa-mir-142 Carcinoma, Non-Small-Cell Lung miR-124 and miR-142 enhance cisplatin sensitivity of non-small cell lung cancer cells through repressing autophagy via directly targeting SIRT1. +lncRNA target 35514319 hsa-mir-205 Lung Neoplasms Taken together, our findings suggest that miR2055p is a key gene targeted by ICA to inhibit lung cancer progression. +lncRNA target 35513844 hsa-mir-15a Endometriosis AFAP1-AS1 bound to BCL9, which was targeted by miR-15a-5p in EMS. +circRNA target 35513835 hsa-mir-5003 Uterine Cervical Neoplasms CONCLUSIONS: As a tumour suppressor, circ_0087429 regulated by EIF4A3 can reverse EMT and inhibit the progression of cervical cancer through the miR +other 35513595 hsa-mir-151a Atrial Fibrillation 5p and miR-151a-5p. +other 35513595 hsa-mir-155 Atrial Fibrillation 5p and miR-151a-5p. +other 35513595 hsa-mir-181a Atrial Fibrillation 5p and miR-151a-5p. +other 35513595 hsa-mir-191 Atrial Fibrillation 5p and miR-151a-5p. +other 35513595 hsa-mir-122 Atrial Fibrillation 5p and miR-151a-5p. +circulation_biomarker_diagnosis_ns 35513513 hsa-mir-141 Carcinoma, Non-Small-Cell Lung The developed biosensor can be successfully used in the early detection of non-small cell lung cancer (NSCLC) by directly measuring miR-141 in human plasma samples. +epigenetics 35512257 hsa-mir-124-2 Cervical Intraepithelial Neoplasia In this multicenter longitudinal cohort study of women with untreated CIN2/3, the prognostic value of FAM19A4/miR124-2 methylation was evaluated for clinical regression. CONCLUSION: Most women with untreated CIN2/3 and a negative baseline FAM19A4/miR124-2 methylation test showed clinical regression. +other 35511922 hsa-mir-210 Leukemia, Myeloid, Acute 5p is found in AML patients in complete remission. +other 35511922 hsa-mir-28 Leukemia, Myeloid, Acute 5p is found in AML patients in complete remission. +transcription factor target 35511493 hsa-mir-21 Breast Neoplasms 5p/Tiam1/PFKL signaling pathway may serve as a target for new anti-BC therapeutic strategies. +genetics_GWAS 35511436 hsa-mir-155 Leukemia, Lymphocytic, Chronic, B-Cell We also found that CLL cells directly regulated miR155 levels in Tn cells, thereby affecting Th17 differentiation, by documenting that coculturing Tn cells with resting or activated (Bact) CLL cells altered the magnitude and direction of T cell miR155 levels; CLL Bact cells promoted IL-17A+ and IL-17F+ T cell generation by an miR155-dependent mechanism, confirmed by miR155 inhibition; coculture of Tn cells with CLL Bact cells led to a linear correlation between the degree and direction of T cell miR155 expression changes and production of IL-17F but not IL-17A; and Bact cell-mediated changes in Tn cell miR155 expression correlated with outcome, irrespective of IGHV mutation status, a strong prognostic indicator. +circulation_biomarker_diagnosis_up 35511316 hsa-mir-203a Colorectal Neoplasms CONCLUSION: This study's findings revealed that serum miR-203a-3p is a fair non-invasive molecular biomarker for diagnosing and progressing tumor grade, tumor stage, and lymph node metastasis in colorectal cancer. +other 35511299 hsa-mir-21 Lung Neoplasms PURPOSE: MicroRNA-21 (miR-21) is a well-known oncomiR and plays key roles in regulating various biological processes related to pulmonary diseases, especially lung carcinoma. +other 35511299 hsa-mir-21 Lung Diseases PURPOSE: MicroRNA-21 (miR-21) is a well-known oncomiR and plays key roles in regulating various biological processes related to pulmonary diseases, especially lung carcinoma. +other 35511171 hsa-mir-101 Carcinoma, Hepatocellular (2) The noncoding RNA miR3142HG and the LINC00265/has-miR3p axis were found to regulate MELK expression in HCC tissue. +other 35511171 hsa-mir-142 Carcinoma, Hepatocellular (2) The noncoding RNA miR3142HG and the LINC00265/has-miR3p axis were found to regulate MELK expression in HCC tissue. +genetics_knock down_promote 35510828 hsa-mir-31 Pancreatic Carcinoma Gain- and loss-of-function assays were also implemented to assess the role of miR +other 35510812 hsa-mir-455 Squamous Cell Carcinoma of Head and Neck CONCLUSION: CHRDL1 plays a vital role in promoting cancer in OSCC and is down-regulated at the mRNA levels by hsa-miR3p. +other 35510740 hsa-mir-133a Muscular Atrophy, Spinal CONCLUSIONS: Lower miR-206 and miR-133a-3p in the CSF predict more robust clinical response to nusinersen treatment in later onset SMA patients. +other 35510740 hsa-mir-206 Muscular Atrophy, Spinal CONCLUSIONS: Lower miR-206 and miR-133a-3p in the CSF predict more robust clinical response to nusinersen treatment in later onset SMA patients. +lncRNA target 35510522 hsa-mir-7 Stomach Neoplasms Microarray analysis suggested that microRNA-7 (miR-7) was the most upregulated miRNA in GC cells after curcumol treatment. In summary, this study suggests that curcumol sensitizes GC cells to cisplatin via miR-7 and the suppression of the NF-kappaB/SNAIL axis. +lncRNA target 35510394 hsa-mir-340 Reperfusion Injury, Cerebral Ischemia All in all, this study clarifies that circPUM1 mitigates cerebral ischemia-reperfusion-induced neuronal injury by targeting the microRNA5p/DEAD-box helicase 5 axis. +circRNA target 35510365 hsa-mir-578 Sepsis These results indicate that circSTRN3 upregulation in sepsis-induced AKI modulates miR-578/TLR4 axis to promote the pathogenesis of AKI, which could serve as future therapeutic targets for AKI treatment. +circRNA target 35510365 hsa-mir-578 Acute Kidney Injury These results indicate that circSTRN3 upregulation in sepsis-induced AKI modulates miR-578/TLR4 axis to promote the pathogenesis of AKI, which could serve as future therapeutic targets for AKI treatment. +transcription factor target 35510354 hsa-mir-103a Acute Kidney Injury MiR-103a-3p was significantly repressed in the sepsis model, while CXCL12 was elevated. Collectively, miR-103a-3p heightens renal cell damage caused by sepsis by targeting CXCL12. +transcription factor target 35510354 hsa-mir-103a Sepsis MiR-103a-3p was significantly repressed in the sepsis model, while CXCL12 was elevated. Collectively, miR-103a-3p heightens renal cell damage caused by sepsis by targeting CXCL12. +other 35510269 hsa-mir-6325 Neuralgia CONCLUSION: In this study, we found that LANCL1 may be a protective factor for NeuP, and the miR-6325/LANCL1 axis may be involved in the occurrence and development of NeuP. +other 35510208 hsa-mir-146 Prostatic Neoplasms CONCLUSIONS: Our study showed that co-expression of miR21, miR-142, miR-143, and miR-146a and the upregulation of miR-21 resulted in increased prostate carcinoma cell growth. +other 35510208 hsa-mir-142 Prostatic Neoplasms CONCLUSIONS: Our study showed that co-expression of miR21, miR-142, miR-143, and miR-146a and the upregulation of miR-21 resulted in increased prostate carcinoma cell growth. +circulation_biomarker_diagnosis_up 35510208 hsa-mir-21 Prostatic Neoplasms In this study, we determined the levels of circulating miR-21, miR-142, miR-143, miR-146a, and RNU 44 levels as controls for early diagnosis of PCa. +other 35510208 hsa-mir-143 Prostatic Neoplasms CONCLUSIONS: Our study showed that co-expression of miR21, miR-142, miR-143, and miR-146a and the upregulation of miR-21 resulted in increased prostate carcinoma cell growth. +other 35510208 hsa-mir-146a Prostatic Neoplasms CONCLUSIONS: Our study showed that co-expression of miR21, miR-142, miR-143, and miR-146a and the upregulation of miR-21 resulted in increased prostate carcinoma cell growth. +genetics_overexpression_promote 35509860 hsa-mir-377 Triple Negative Breast Neoplasms 3p were overexpressed or knocked down in the TNBC cells, respectively. +other 35509844 hsa-mir-429 Stomach Neoplasms RESULTS: In gastric cancer, the circ-0007707/miR-429/PDGFD pathway had a differential expression. CONCLUSION: The circ-0007707/miR-429/PDGFD pathway may play a regulatory role in the progression and prognosis of gastric cancer by interfering with the tumor microenvironment, and the PDGFD-related immune-gene signature could be considered a moderator of prognostic factor for gastric cancer and to guide immunotherapy programs. +transcription factor target 35509839 hsa-mir-9 Parkinson Disease 5p might be a potential therapeutic target against Parkinson's disease. +epigenetics 35509266 hsa-mir-495 Periodontitis 3p expression by demethylation of H3K4me3 to enhance HOXC8 transcription, thereby increasing the HOXC8 and limiting OD, proliferation, and migration of hPDLSCs with periodontitis. +circRNA target 35509064 hsa-mir-516a Carcinoma, Hepatocellular Moreover, circTOLLIP sponged miR-516a-5p to elevate the expression of PBX3, thereby activating the epithelial-to-mesenchymal transition (EMT) pathway and facilitating tumor progression in HCC. CONCLUSIONS: Our findings indicate that EIF4A3-induced circTOLLIP promotes the progression of HCC through the circTOLLIP/miR-516a-5p/PBX3/EMT axis. +other 35508523 hsa-mir-421 Colorectal Neoplasms Additionally, SP1 could facilitate the tumorigenesis of CRC cells in vivo by regulating the TUG1/miR-421/KDM2A/ERK axis. Altogether, the current study emphasizes the oncogenic role of TUG1 in CRC, and illustrates its interactions with the upstream transcription factor SP1 and the downstream modulatory axis miR-421/KDM2A/ERK, thus offering novel insights into the cancerogenic mechanism in CRC. +lncRNA target 35508470 hsa-mir-17 Osteoarthritis Supplementation of exogenous miR-17 or its endogenous induction by growth differentiation factor 5, effectively prevented OA by simultaneously targeting pathological catabolic factors including matrix metallopeptidase-3/13 (MMP3/13), aggrecanase-2 (ADAMTS5), and nitric oxide synthase-2 (NOS2). +lncRNA target 35508298 hsa-mir-144 Carcinoma, Non-Small-Cell Lung Moreover, the expression analysis, correlation analysis, and survival analysis revealed that POSTN-targeted miRNAs, downregulation of has-miR3p and has-miR-30e-3p, were significantly linked to poor prognosis in patients with LUSC. +genetics_GWAS 35507777 hsa-mir-125b Hypertension, Pulmonary miRNA-sequencing analysis of the genetic cargo of MSC-NVs revealed that miR-125b-5p and miR +genetics_GWAS 35507777 hsa-mir-100 Hypertension, Pulmonary miRNA-sequencing analysis of the genetic cargo of MSC-NVs revealed that miR-125b-5p and miR +lncRNA target 35507744 hsa-mir-144 Microvascular Obstruction 3p targeted ROCK1 to radically activate the PI3K/AKT/mTOR pathway. +circulation_biomarker_diagnosis_up 35507256 hsa-mir-203 ST Elevation Myocardial Infarction Logistic regression analysis showed that miRNA-203 and white blood cell counts were independent risk factors for STEMI (P<0.05), and their ORs (95% CI) were 3.913 (1.574-9.728) and 2.13 (1.247-3.641), respectively. +genetics_GWAS 35506422 hsa-mir-130a Carcinoma, Renal Cell Furthermore, exogenetic expression of CEP55 counteracted miR-130a-3p overexpression-mediated effects on malignant phenotypes and angiogenesis of RCC cells. +circulation_biomarker_diagnosis_up 35506414 hsa-mir-24 Pre-Eclampsia 3p and 11beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) was analyzed in the blood and cells. +circRNA target 35506311 hsa-mir-148a Duane Retraction Syndrome miR-148a-3p is downregulated in DR patients. As the molecular sponge of miR-148a-3p, circFTO regulated cell viability and apoptosis and promoted the progression of DR through regulating the expression of TGFA. +other 35506305 hsa-mir-101 Respiratory Distress Syndrome 3p plays a role in PARDS, providing a novel angle to study the disease. +circulation_biomarker_diagnosis_up 35506298 hsa-mir-155 Respiratory Distress Syndrome We found significant upregulation of miR5p expression in serum samples from patients with ARDS compared with the control group (p < 0.01). +genetics_overexpression_promote 35506252 hsa-mir-940 Squamous Cell Carcinoma of Head and Neck BBOX1-AS1 and LAMC2 were notably overexpressed in OSCC, while miR +other 35506187 hsa-mir-218 Norrie disease OBJECTIVES: Since inflammation plays a key role in DN, and SPRED2 is known to facilitate cell autophagy, the present study aimed to investigate the role and molecular mechanism of miR-218 and SPRED2-mediated autophagy in high glucose (HG)-induced renal tubular epithelial cells using an in vitro model. +other 35506187 hsa-mir-218 Diabetes Mellitus MicroRNA (miR)-218 is associated with the development of diabetes. +transcription factor target 35506187 hsa-mir-218 Inflammation Besides, sprouty-related EVH1 domain containing 2 (SPRED2), the downstream target of miR-218, is involved in insulin resistance and inflammation. +lncRNA target 35506168 hsa-mir-491 Glioblastoma Silencing H19 inhibited growth and promoted apoptosis in GBM cells both in vitro and in vivo, and miR +exosome 35506070 hsa-mir-210 Hypertension, Pulmonary We found that the amount of pro-proliferative miR3p was increased in PVEC-derived EV in hypoxia (H-EV), which contributes to the H-EV-induced proliferation of PASMC and the development of PH. +other 35505969 hsa-mir-766 Thyroid Cancer, Papillary A diagnostic and predictive lncRNA lnc-MPEG1-1 promotes the proliferation and metastasis of papillary thyroid cancer cells by occupying miR-766-5p. +genetics_overexpression_suppress 35505968 hsa-mir-10a Diabetic Nephropathies Our finding suggests that overexpressing miR-10a/b in kidney may be a promising method for the treatment of fibrosis in DKD. +genetics_overexpression_suppress 35505968 hsa-mir-10b Diabetic Nephropathies Our finding suggests that overexpressing miR-10a/b in kidney may be a promising method for the treatment of fibrosis in DKD. +genetics_overexpression_suppress 35505968 hsa-mir-10a Fibrosis, Renal Our finding suggests that overexpressing miR-10a/b in kidney may be a promising method for the treatment of fibrosis in DKD. +genetics_overexpression_suppress 35505968 hsa-mir-10b Fibrosis, Renal Our finding suggests that overexpressing miR-10a/b in kidney may be a promising method for the treatment of fibrosis in DKD. +genetics_overexpression_promote 35505304 hsa-mir-618 Colorectal Neoplasms CONCLUSION: Circ-ATAD1 is overexpressed in CRC and may suppress miR-618 maturation to participate in CRC. +other 35505296 hsa-mir-33a Diabetes, Gestational qPCR analysis indicated that LINC00667, YTHDF3 and MYC levels were upregulated in the GDM placentas, while miR-33a-5p was downregulated. In a support-vector machine classifier, an m6A-related module composed of LINC00667, YTHDF3, MYC, and miR-33a-5p showed excellent classifying power for GDM in both the training and the testing dataset, with an accuracy of 76.19 and 71.43%, respectively. +epigenetics 35505294 hsa-mir-138 Uterine Cervical Neoplasms CONCLUSION: We demonstrated that miR-138 suppresses tumor progression by targeting EZH2 in cervical cancer and uncovered the role of DNA methylation in the miR-138 promoter in its downregulation. +lncRNA target 35504804 hsa-mir-21 Intestinal Diseases RESULTS: Compared to the controls, miR-21 was significantly upregulated in the intestinal tissues from CD patients with fibro stenosis, followed by decreased PTEN expression, increased EMT markers, and mTOR expression, and imbalanced ratio of MMP9(matrix metalloproteinase 9)/TIMP1(tissue inhibitor of metalloproteinase 1). +lncRNA target 35504804 hsa-mir-21 Crohn Disease RESULTS: Compared to the controls, miR-21 was significantly upregulated in the intestinal tissues from CD patients with fibro stenosis, followed by decreased PTEN expression, increased EMT markers, and mTOR expression, and imbalanced ratio of MMP9(matrix metalloproteinase 9)/TIMP1(tissue inhibitor of metalloproteinase 1). +lncRNA target 35504332 hsa-mir-217 Pancreatic Carcinoma Therefore, hsa-miR-217 abrogates pancreatic cancer progression through inactivation of the AKT signaling pathway and this might be partly due to miR-217 mediated suppression of ATAD2 expression. SIGNIFICANCE: The application of hsa-miR-217 mimic could be a promising therapeutic strategy for the treatment of pancreatic cancer patients in near future. +lncRNA target 35504176 hsa-mir-1290 Esophageal Squamous Cell Carcinoma Collectively, our study demonstrates that ZNF667-AS1 can function as a tumor suppressor in ESCC by upregulating PRUNE2 and downregulating miR-1290. +lncRNA target 35504053 hsa-mir-103a Endometriosis Given the existing literature and our predictions through starBase in this research, it was assumed that circATRNL1 might orchestrate the microRNA (miR)- 103a-3p/acid-sensing ion channel 1 (ASIC1) axis to control EMT in endometriosis. +lncRNA target 35503998 hsa-mir-183 Urinary Bladder Neoplasms OBJECTIVE: To uncover novel prognostic and therapeutic targets for BLCA, our study is the first to investigate the role of hsa-mir-183 and its up-regulated predicted target genes in bladder urothelial carcinoma. METHODS: To address this issue, our study explored the roles of hsa-mir-183 predicted target genes in the prognosis of BLCA via UALCAN, Metascape, Kaplan-Meier plotter, Human Protein Atlas, TIMER2.0, cBioPortal and Genomics of Drug Sensitivity in Cancer databases. +other 35503860 hsa-mir-21 Breast Neoplasms Herein, the upconversion nanoparticle@Au (UCNP@Au) core-satellite nanostructures are rationally fabricated for isothermal amplification detection and in situ imaging of microRNA-21 (miR-21) in living cells based on the toehold-mediated strand displacement (TMSD) reaction, which is further applied to miRNA-responsive combined photothermal and photodynamic therapy of breast cancer. +transcription factor target 35503501 hsa-mir-1273d Pre-Eclampsia EVs secreted by human trophoblast cells under hypoxic conditions were associated with 3 key upstream miRNAs of HLA-G, namely miR-1273d, miR-4492, and miR-4417, which might be implicated in the development of preeclampsia via targeting of HLA-G. Collectively, our findings highlighted that EVs secreted by human trophoblast cells under hypoxic conditions transferred miR-1273d, miR-4492, and miR-4417, all of which targeted HLA-G, thus orchestrating immune- and inflammation-related pathways and consequently promoting the development of preeclampsia. +transcription factor target 35503501 hsa-mir-4492 Pre-Eclampsia EVs secreted by human trophoblast cells under hypoxic conditions were associated with 3 key upstream miRNAs of HLA-G, namely miR-1273d, miR-4492, and miR-4417, which might be implicated in the development of preeclampsia via targeting of HLA-G. Collectively, our findings highlighted that EVs secreted by human trophoblast cells under hypoxic conditions transferred miR-1273d, miR-4492, and miR-4417, all of which targeted HLA-G, thus orchestrating immune- and inflammation-related pathways and consequently promoting the development of preeclampsia. +transcription factor target 35503501 hsa-mir-4417 Pre-Eclampsia EVs secreted by human trophoblast cells under hypoxic conditions were associated with 3 key upstream miRNAs of HLA-G, namely miR-1273d, miR-4492, and miR-4417, which might be implicated in the development of preeclampsia via targeting of HLA-G. Collectively, our findings highlighted that EVs secreted by human trophoblast cells under hypoxic conditions transferred miR-1273d, miR-4492, and miR-4417, all of which targeted HLA-G, thus orchestrating immune- and inflammation-related pathways and consequently promoting the development of preeclampsia. +genetics_overexpression_suppress 35503407 hsa-mir-196b Esophageal Neoplasms Overexpressed ADAMTS9-AS2 regulated the tumor-forming ability of EC cells in vivo through miR-196b-5p/PPP1R12B/cell cycle signaling pathway axis. +lncRNA target 35503215 hsa-mir-182 Myocardial Reperfusion Injury 5p regulates the apoptosis and ROS and protects against myocardial I/R injury by targeting STK17A. +exosome 35503135 hsa-mir-130a Myocardial Reperfusion Injury The protective action of EV-carried miR-130a-3p was further re-produced in a rat model serving as in vivo validation as evidenced by improved cardiac function, tissue injury, myocardial fibrosis, and myocardial infarction. +other 35503041 hsa-mir-195 Aortic Aneurysm, Thoracic Tissue expression of microRNA 195 was 2.72-fold higher in the dissection (P < .001) and 2.00-fold lower in the aneurysm group (P = .08), compared with to the control group. +genetics_overexpression_promote 35502885 hsa-mir-766 Squamous Cell Carcinoma of Head and Neck 5p inhibition and overexpression of HMGA2 rescued the tumor-suppressing roles of circSHKBP1 downregulation in LSCC. +target gene 35502349 hsa-mir-124 Melanoma LncRNA LNCOC1 is Upregulated in Melanoma and Serves as a Potential Regulatory Target of miR-124 to Suppress Cancer Cell Invasion and Migration. +circulation_biomarker_diagnosis_up 35501921 hsa-mir-21 Ovarian Neoplasms METHODS: Databases, such as PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), and China WanFang, were searched for relevant studies upon the correlation between the expression of serum miR-21 and the diagnostic value of ovarian cancer from inception to March 7, 2022. +genetics_knock down_promote 35501825 hsa-mir-600 Ovarian Neoplasms Si-KLF9 partially abolished the discrepancy of self-renewal, growth and metastasis capacity between miR-600 knockdown ovarian cancer cells and control cells. +circulation_biomarker_prognosis_ns 35501813 hsa-mir-182 Cardiomegaly ROC curve indicated the diagnostic value of serum miR +lncRNA target 35501800 hsa-mir-144 Urinary Bladder Neoplasms CONCLUSION: Our data demonstrate that ZBTB7A, a targeted gene of miR +circulation_biomarker_diagnosis_up 35501673 hsa-mir-196b Colorectal Neoplasms In plasma, miR-196b-5p was the most sensitive (0.97; p < .001) and specific (0.94; p < .001) in detecting CRC. +circRNA target 35501594 hsa-mir-93 Uterine Cervical Neoplasms 5p, and down-regulated FRMD6 reversed the cell viability, migration and invasion of cervical cancer cells inhibited by anti-miR +other 35501543 hsa-mir-214 Heart Failure, Chronic Further studies in PC12 cells revealed that miR3p enhanced the inflammatory response, while let-7g-5p and let-7i-5p reduced the neuroinflammation. +other 35501543 hsa-let-7i Heart Failure, Chronic Further studies in PC12 cells revealed that miR3p enhanced the inflammatory response, while let-7g-5p and let-7i-5p reduced the neuroinflammation. +other 35501543 hsa-let-7g Heart Failure, Chronic Further studies in PC12 cells revealed that miR3p enhanced the inflammatory response, while let-7g-5p and let-7i-5p reduced the neuroinflammation. +transcription factor target 35501542 hsa-mir-16 Graft Occlusion, Vascular The miR5p/zyxin axis is a novel, potentially therapeutic target for preventing and treating venous graft intimal hyperplasia. +transcription factor target 35501542 hsa-mir-16 Endometrial Hyperplasia The miR5p/zyxin axis is a novel, potentially therapeutic target for preventing and treating venous graft intimal hyperplasia. +genetics_knock down_promote 35501464 hsa-mir-622 Prostatic Neoplasms In addition, miR-3622 KO inhibited the epithelial-mesenchymal transition involved in prostate cancer metastasis via upregulation of vimentin. +exosome 35501306 hsa-mir-1298 Glioma Interestingly, exosomal miR +genetics_overexpression_suppress 35500803 hsa-mir-1283 Carcinoma, Hepatocellular MiR-1283 inhibitor incompletely counteracted the effect of si-circ_0005397 on HCC cell progression, while HEG1 overexpression partially overturned the effect of miR-1283 on HCC cell progression. CONCLUSIONS: Circ_0005397 regulated HEG1 by targeting miR-1283, thereby promoting HCC development. +other 35500644 hsa-mir-155 COVID-19 The aim of this study was to investigate the expression patterns of inflammation-related non-coding RNAs (ncRNAs) including MALAT-1, NEAT-1, THRIL, and miR5p from the acute phase to the recovery phase of COVID-19. +other 35500644 hsa-mir-150 COVID-19 DISCUSSION: Inflammation-related ncRNAs (MALAT-1, THRIL, and miR5p) can act as hopeful biomarkers for the monitoring and diagnosis of COVID-19 disease. +circRNA target 35500159 hsa-mir-615 Carcinoma, Non-Small-Cell Lung 5p/PAK1 axis, which might provide a new therapeutic target for NSCLC treatment. +other 35500065 hsa-mir-299 Thyroid Cancer, Papillary 5p, miR-376a-3p, and miR-302E) had a significant differential expression in cytological samples of papillary carcinoma with lymph node metastases and predicted the positive nodal status with a relatively good performance. +other 35500065 hsa-mir-376a Thyroid Cancer, Papillary 5p, miR-376a-3p, and miR-302E) had a significant differential expression in cytological samples of papillary carcinoma with lymph node metastases and predicted the positive nodal status with a relatively good performance. +other 35500065 hsa-mir-154 Thyroid Cancer, Papillary 5p, miR-376a-3p, and miR-302E) had a significant differential expression in cytological samples of papillary carcinoma with lymph node metastases and predicted the positive nodal status with a relatively good performance. +other 35499677 hsa-mir-6024 Necrobiotic Disorders With the elucidation of the necrotrophic disease-synergistic role played by miR6024, it becomes a potent candidate for biotechnological manipulation for the rapid development of pathogen-tolerant solanaceous plants. +genetics_overexpression_promote 35499320 hsa-mir-149 Triple Negative Breast Neoplasms In rescue assays, it was proven that overexpressing CTCF and CTNNB1 or inhibiting miR +genetics_GWAS 35499218 hsa-mir-196a-2 Esophageal Neoplasms To investigate the relationship between miR-146a rs2910164 C>G, miR-196a2 rs11614913 T>C, and miR-499 rs3746444 A>G polymorphisms and the susceptibility to esophageal squamous cell cancer (ESCC) in the Chinese Han nationality, we recruited 829 cases and 1522 controls in our study. +genetics_GWAS 35499218 hsa-mir-146a Esophageal Neoplasms To investigate the relationship between miR-146a rs2910164 C>G, miR-196a2 rs11614913 T>C, and miR-499 rs3746444 A>G polymorphisms and the susceptibility to esophageal squamous cell cancer (ESCC) in the Chinese Han nationality, we recruited 829 cases and 1522 controls in our study. +genetics_GWAS 35499218 hsa-mir-499 Esophageal Neoplasms To investigate the relationship between miR-146a rs2910164 C>G, miR-196a2 rs11614913 T>C, and miR-499 rs3746444 A>G polymorphisms and the susceptibility to esophageal squamous cell cancer (ESCC) in the Chinese Han nationality, we recruited 829 cases and 1522 controls in our study. +lncRNA target 35499148 hsa-mir-34c Pulmonary Fibrosis Dysregulation of microRNA-34c (miR-34c) is highly correlated with organ fibrosis including pulmonary fibrosis. +genetics_overexpression_suppress 35499128 hsa-mir-145 Breast Neoplasms Meanwhile, miR-145 overexpression facilitated the docetaxel sensitivity of BC cells in vivo and in vitro, while the miR-145 inhibitor decreased the sensitivity of BC cells to docetaxel. +genetics_overexpression_promote 35499081 hsa-mir-21 Lupus Erythematosus, Systemic Using human cells and murine models, the authors demonstrated that miR-21 was overexpressed in lupus T cells and inhibited 3-hydroxybutyrate dehydrogenase-2 (BDH2). +other 35499057 hsa-mir-532 Uterine Cervical Neoplasms 5p/orlistat as novel strategy for treating patients with LNM in CC. +lncRNA target 35498540 hsa-mir-185 Laryngeal Neoplasms In conclusion, LINC01278 plays an oncogenic role in laryngeal cancer by suppressing miR5p to enhance CST1 expression, which enriches the molecular mechanism for the carcinogenesis of laryngeal cancer. +circulation_biomarker_diagnosis_ns 35498403 hsa-mir-21 Non-alcoholic Fatty Liver Disease 5p levels were higher in children with IR and NAFLD, and their expression levels correlated with hepatic fat and serum triglyceride. +circulation_biomarker_diagnosis_ns 35498403 hsa-mir-155 Non-alcoholic Fatty Liver Disease 3p levels correlated with plasma adiponectin (r = -0.71 and r = -0.75, respectively, p<0.05) and fibroblast growth factor-21 (r = -0.73 and r = -0.89, respectively, p<0.01). +circulation_biomarker_diagnosis_ns 35498403 hsa-mir-22 Non-alcoholic Fatty Liver Disease 3p levels correlated with plasma adiponectin (r = -0.71 and r = -0.75, respectively, p<0.05) and fibroblast growth factor-21 (r = -0.73 and r = -0.89, respectively, p<0.01). +other 35498402 hsa-mir-155 Diabetes Of The Exocrine Pancreas 5p-TLR4 might lead to TLR4 signaling pathway activation in DEP. +other 35498402 hsa-mir-21 Diabetes Of The Exocrine Pancreas 5p-TLR4 might lead to TLR4 signaling pathway activation in DEP. +other 35498402 hsa-mir-27a Diabetes Of The Exocrine Pancreas 5p-TLR4 might lead to TLR4 signaling pathway activation in DEP. +lncRNA target 35498204 hsa-mir-375 Cardiomyopathies 3p promoted fibrosis by accelerating the ferroptosis of cardiomyocytes through mediating glutathione peroxidase 4 (GPX4). +circulation_biomarker_diagnosis_ns 35498136 hsa-mir-24 Blood Coagulation Disorders, Traumatic, Acute Both the liver tissues of ATC rats and peripheral blood samples from ATC patients showed increased hsa-miR +circulation_biomarker_diagnosis_ns 35498018 hsa-let-7c Hypertension CONCLUSIONS: Our data demonstrated that circulating levels of several miRNAs, in particular miR5p, miR-451, and let7c, were associated with LVH in hypertensive patients, indicating that these miRNAS may be potential circulating biomarkers or involved in hypertension-induced LV remodeling. +circulation_biomarker_diagnosis_ns 35498018 hsa-mir-145 Hypertrophy, Left Ventricular CONCLUSIONS: Our data demonstrated that circulating levels of several miRNAs, in particular miR5p, miR-451, and let7c, were associated with LVH in hypertensive patients, indicating that these miRNAS may be potential circulating biomarkers or involved in hypertension-induced LV remodeling. +circulation_biomarker_diagnosis_ns 35498018 hsa-mir-145 Hypertension CONCLUSIONS: Our data demonstrated that circulating levels of several miRNAs, in particular miR5p, miR-451, and let7c, were associated with LVH in hypertensive patients, indicating that these miRNAS may be potential circulating biomarkers or involved in hypertension-induced LV remodeling. +circulation_biomarker_diagnosis_ns 35498018 hsa-mir-451 Hypertrophy, Left Ventricular CONCLUSIONS: Our data demonstrated that circulating levels of several miRNAs, in particular miR5p, miR-451, and let7c, were associated with LVH in hypertensive patients, indicating that these miRNAS may be potential circulating biomarkers or involved in hypertension-induced LV remodeling. +circulation_biomarker_diagnosis_ns 35498018 hsa-mir-451 Hypertension CONCLUSIONS: Our data demonstrated that circulating levels of several miRNAs, in particular miR5p, miR-451, and let7c, were associated with LVH in hypertensive patients, indicating that these miRNAS may be potential circulating biomarkers or involved in hypertension-induced LV remodeling. +circulation_biomarker_diagnosis_ns 35498018 hsa-let-7c Hypertrophy, Left Ventricular CONCLUSIONS: Our data demonstrated that circulating levels of several miRNAs, in particular miR5p, miR-451, and let7c, were associated with LVH in hypertensive patients, indicating that these miRNAS may be potential circulating biomarkers or involved in hypertension-induced LV remodeling. +transcription factor target 35497882 hsa-mir-3918 Glioma The results of KEGG revealed that the targeting genes of hsa-miR-3918 were primarily related to MAPK signal pathway, PI3K-Akt signal pathway, and human papillomavirus infection. +transcription factor target 35497882 hsa-mir-3918 Primary Central Nervous System Lymphoma The results of KEGG revealed that the targeting genes of hsa-miR-3918 were primarily related to MAPK signal pathway, PI3K-Akt signal pathway, and human papillomavirus infection. +lncRNA target 35497876 hsa-mir-22 Colorectal Neoplasms Taken together, SETDB1 could activate the BATF3/PD-L1 axis by inhibiting FOSB-mediated miR-22 and promote immune evasion in CRC, which provides a better understanding of the mechanisms underlying immune evasion in CRC. +lncRNA target 35497503 hsa-mir-122 Hepatitis C Formerly, we were able to inhibit hepatitis C virus propagation by applying a circular RNA decoy strategy against microRNA-122, which is essential for the viral life cycle. +genetics_overexpression_promote 35495878 hsa-mir-93 Urinary Bladder Neoplasms 5p overexpression promoted BUC cell abilities. +other 35495611 hsa-mir-20a Chronic Pelvic Pain Syndrome Further qPCR assays validated that several chronic pain-related miRNAs, including miR5p, let-7d-3p, let-7b-3p, let-7c-3p, miR-146a-5p, and miR-320a-5p, were differentially expressed. +other 35495611 hsa-mir-146a Chronic Pelvic Pain Syndrome Further qPCR assays validated that several chronic pain-related miRNAs, including miR5p, let-7d-3p, let-7b-3p, let-7c-3p, miR-146a-5p, and miR-320a-5p, were differentially expressed. +other 35495611 hsa-mir-204 Chronic Pelvic Pain Syndrome Further qPCR assays validated that several chronic pain-related miRNAs, including miR5p, let-7d-3p, let-7b-3p, let-7c-3p, miR-146a-5p, and miR-320a-5p, were differentially expressed. +other 35495611 hsa-let-7c Chronic Pelvic Pain Syndrome Further qPCR assays validated that several chronic pain-related miRNAs, including miR5p, let-7d-3p, let-7b-3p, let-7c-3p, miR-146a-5p, and miR-320a-5p, were differentially expressed. +other 35495611 hsa-let-7b Chronic Pelvic Pain Syndrome Further qPCR assays validated that several chronic pain-related miRNAs, including miR5p, let-7d-3p, let-7b-3p, let-7c-3p, miR-146a-5p, and miR-320a-5p, were differentially expressed. +other 35495611 hsa-let-7d Chronic Pelvic Pain Syndrome Further qPCR assays validated that several chronic pain-related miRNAs, including miR5p, let-7d-3p, let-7b-3p, let-7c-3p, miR-146a-5p, and miR-320a-5p, were differentially expressed. +other 35495596 hsa-mir-125b Abortion, Habitual In the present study, the expression of NEAT1 and Bcl-2 was reduced and that of miR-125b was increased in clinical samples of villus tissues from patients with RSAs. +other 35495318 hsa-mir-21 Kidney Diseases MicroRNA-21 (miRNA-21) is a significant biomarker which is closely related to some kinds of diseases, such as cancer, cardiovascular disease and kidney disease. +other 35495318 hsa-mir-21 Cardiovascular Diseases MicroRNA-21 (miRNA-21) is a significant biomarker which is closely related to some kinds of diseases, such as cancer, cardiovascular disease and kidney disease. +genetics_GWAS 35495171 hsa-let-7a Uterine Cervical Neoplasms Nine SNPs in miRNA genes (rs107822 in miR-219a, rs10877887 in let-7i, rs2292832 in miR-149, rs353293 in miR-143, rs3746444 in miR-499, rs3803808 in miR-132, rs4078756 in miR-10b, rs629367 in let-7a, and rs7372209 in miR-26a) were genotyped using MassArray, and the association of these SNPs with CIN and CC were analysed. +genetics_GWAS 35495171 hsa-mir-149 Uterine Cervical Neoplasms Nine SNPs in miRNA genes (rs107822 in miR-219a, rs10877887 in let-7i, rs2292832 in miR-149, rs353293 in miR-143, rs3746444 in miR-499, rs3803808 in miR-132, rs4078756 in miR-10b, rs629367 in let-7a, and rs7372209 in miR-26a) were genotyped using MassArray, and the association of these SNPs with CIN and CC were analysed. +genetics_GWAS 35495171 hsa-mir-219a Uterine Cervical Neoplasms Nine SNPs in miRNA genes (rs107822 in miR-219a, rs10877887 in let-7i, rs2292832 in miR-149, rs353293 in miR-143, rs3746444 in miR-499, rs3803808 in miR-132, rs4078756 in miR-10b, rs629367 in let-7a, and rs7372209 in miR-26a) were genotyped using MassArray, and the association of these SNPs with CIN and CC were analysed. +genetics_GWAS 35495171 hsa-mir-132 Uterine Cervical Neoplasms Nine SNPs in miRNA genes (rs107822 in miR-219a, rs10877887 in let-7i, rs2292832 in miR-149, rs353293 in miR-143, rs3746444 in miR-499, rs3803808 in miR-132, rs4078756 in miR-10b, rs629367 in let-7a, and rs7372209 in miR-26a) were genotyped using MassArray, and the association of these SNPs with CIN and CC were analysed. +genetics_GWAS 35495171 hsa-mir-10b Uterine Cervical Neoplasms Nine SNPs in miRNA genes (rs107822 in miR-219a, rs10877887 in let-7i, rs2292832 in miR-149, rs353293 in miR-143, rs3746444 in miR-499, rs3803808 in miR-132, rs4078756 in miR-10b, rs629367 in let-7a, and rs7372209 in miR-26a) were genotyped using MassArray, and the association of these SNPs with CIN and CC were analysed. +genetics_GWAS 35495171 hsa-mir-26a Uterine Cervical Neoplasms Nine SNPs in miRNA genes (rs107822 in miR-219a, rs10877887 in let-7i, rs2292832 in miR-149, rs353293 in miR-143, rs3746444 in miR-499, rs3803808 in miR-132, rs4078756 in miR-10b, rs629367 in let-7a, and rs7372209 in miR-26a) were genotyped using MassArray, and the association of these SNPs with CIN and CC were analysed. +genetics_GWAS 35495171 hsa-mir-143 Uterine Cervical Neoplasms Nine SNPs in miRNA genes (rs107822 in miR-219a, rs10877887 in let-7i, rs2292832 in miR-149, rs353293 in miR-143, rs3746444 in miR-499, rs3803808 in miR-132, rs4078756 in miR-10b, rs629367 in let-7a, and rs7372209 in miR-26a) were genotyped using MassArray, and the association of these SNPs with CIN and CC were analysed. +genetics_GWAS 35495171 hsa-mir-499 Uterine Cervical Neoplasms Nine SNPs in miRNA genes (rs107822 in miR-219a, rs10877887 in let-7i, rs2292832 in miR-149, rs353293 in miR-143, rs3746444 in miR-499, rs3803808 in miR-132, rs4078756 in miR-10b, rs629367 in let-7a, and rs7372209 in miR-26a) were genotyped using MassArray, and the association of these SNPs with CIN and CC were analysed. +genetics_GWAS 35495171 hsa-let-7i Uterine Cervical Neoplasms Nine SNPs in miRNA genes (rs107822 in miR-219a, rs10877887 in let-7i, rs2292832 in miR-149, rs353293 in miR-143, rs3746444 in miR-499, rs3803808 in miR-132, rs4078756 in miR-10b, rs629367 in let-7a, and rs7372209 in miR-26a) were genotyped using MassArray, and the association of these SNPs with CIN and CC were analysed. +other 35495167 hsa-mir-429 Rectal Neoplasms Fourthly, we constructed a rectal cancer-related ceRNA network and detected several typical lncRNA-miRNA-mRNA crosstalk, such as HAND2-AS1, HAND2 and miR-20a-5p crosstalk and MBNL1-AS1, miR-429 and LONRF2 crosstalk, which were validated to function in improving overall survival of rectal cancer patients. +circulation_biomarker_diagnosis_up 35494527 hsa-mir-100 Pulmonary Disease, Chronic Obstructive CONCLUSION: miR-100 and TRIB2 were expressed abnormally in serum of COPD patients, and miR-100 could inhibit proliferation of pulmonary fibroblasts and promote their apoptosis. +lncRNA target 35494514 hsa-mir-129 Arthritis, Rheumatoid 5p, and BRD4 upregulation could partly rescue the inhibition of miR +lncRNA target 35494512 hsa-mir-4504 Colorectal Neoplasms NBAT-1 bound miR-4504 and decreased miR-4504 expression in CRC cells. CONCLUSIONS: These findings demonstrated that lncRNA NBAT-1 suppresses OXA-resistant CRC cell growth via inhibition of miR-4504 to regulate the WWC3/LATS1/YAP axis. +other 35494481 hsa-mir-103a Postoperative Cognitive Complications Taken together, the data show that miR-103a-3p/VAMP1 is critical for surgery-induced microglial activation of POCD. +other 35494201 hsa-mir-135b Infertility The microRNA-135b is a potential biomarker to predict IVF embryo quality. +genetics_GWAS 35494025 hsa-mir-126 Carcinoma, Non-Small-Cell Lung The Polymorphism and Expression of EGFL7 and miR-126 Are Associated With NSCLC Susceptibility. +lncRNA target 35493998 hsa-mir-1294 Osteosarcoma qRT-PCR was used to assess the expressions of circOMA1, miR-1294, and c-Myc in osteosarcoma tissues. CONCLUSION: circOMA1 played the role of an oncogene in osteosarcoma and promoted osteosarcoma progression by mediating the miR-1294/c-Myc pathway, which might be a new target for treating osteosarcoma. +target gene 35493691 hsa-mir-384 Osteosarcoma Luteolin attenuates the chemoresistance of osteosarcoma through inhibiting the PTN/β-catenin/MDR1 signaling axis by upregulating miR-384. +lncRNA target 35493459 hsa-mir-101 Carcinoma, Hepatocellular This study aimed to investigate the potential role of CCDC88A on malignancies and stemness by regulating VEGF via miR-101 in HCC. +genetics_knock down_promote 35493425 hsa-mir-148a ankylosing spondylitis 1 DKK1 knockdown averted the effect of silencing miR-148a-3p in AS fibroblasts. +circRNA target 35492076 hsa-mir-543 Glioma The circ-ASB3/miR-543/Twist1 axis was discovered to be a possible regulatory pathway in glioma, circ-ASB3 could adsorb and targeted bind to miR-543, down-regulate miR-543 expression, thus release its targeted inhibition to Twist1. +lncRNA target 35491874 hsa-mir-26a Sepsis Thus, our study indicated that the miR-26a-5p/IL-6 axis can alleviate sepsis-induced acute kidney injury by inhibiting renal inflammation. +lncRNA target 35491874 hsa-mir-26a Acute Kidney Injury Thus, our study indicated that the miR-26a-5p/IL-6 axis can alleviate sepsis-induced acute kidney injury by inhibiting renal inflammation. +other 35491723 hsa-mir-139 Carcinoma, Non-Small-Cell Lung Conclusion: We thus conclude that circPTPRM promotes the progression of NSCLC by regulating the miR5p/SETD5 axis. +genetics_overexpression_promote 35491288 hsa-mir-188 Keloid In addition, VEGFA overexpression also abolished the suppressive effect of miR +transcription factor target 35490917 hsa-mir-214 Carcinoma, Hepatocellular Our data suggest that miRNA-214 regulates DNA replication by targeting MCM5/7 and has the potential to be developed into a liver cancer drug. Furthermore, the potential of miR-214 as an anticancer agent, with activity against liver cancer cells but not normal livre cells, may be of high significance. +genetics_knock down_promote 35490895 hsa-mir-374b Glioma What's more, overexpression of miR-374b or knockdown of SALL1 reversed the inhibitory effect of lncRNA PART1 on the proliferation, migration, and EMT of glioma cells. +other 35490865 hsa-mir-29a Obesity RESULTS: Here we found that mature neurons originating from the POMC lineage employ miR-29a to protect against insulin resistance obesity, hyperphagia, decreased energy expenditure and obesity. Moreover, POMC(Cre)-dependent co-deletion of Nras in mature neurons attenuated miR-29 depletion-induced obesity. +other 35490865 hsa-mir-29 Obesity RESULTS: Here we found that mature neurons originating from the POMC lineage employ miR-29a to protect against insulin resistance obesity, hyperphagia, decreased energy expenditure and obesity. Moreover, POMC(Cre)-dependent co-deletion of Nras in mature neurons attenuated miR-29 depletion-induced obesity. +transcription factor target 35490837 hsa-mir-223 Dry Eye Syndromes This inverse regulation between miR-223 and NLRP3 expression levels suggests that selective upregulation of miR-223 expression may be a novel option to suppress chronic inflammation in DE. +lncRNA target 35490654 hsa-mir-629 Cholangiocarcinoma CONCLUSION: Upregulation of circ_0059961 augmented SFRP2 expression by targeting miR5p, which blocked cholangiocarcinoma tumor cell proliferation, migration, and invasion. +other 35490653 hsa-mir-23a Pituitary Neoplasms By using bioinformatics tools and a series of mechanism assays, LINC01004 was identified to sponge miR-323a-3p/miR5p to enhance the expression of RCN2 in PA. +other 35490653 hsa-mir-136 Pituitary Neoplasms By using bioinformatics tools and a series of mechanism assays, LINC01004 was identified to sponge miR-323a-3p/miR5p to enhance the expression of RCN2 in PA. +other 35490305 hsa-mir-206 Glioblastoma 5p suggested the association with poor prognosis in glioblastoma patients. +genetics_overexpression_promote 35490208 hsa-mir-371b Triple Negative Breast Neoplasms In patients with TNBC, miR-371b-5p expression was reduced, and miR-371b-5p overexpression significantly mitigated TNBC cell growth, migration, and invasion. +lncRNA target 35490173 hsa-mir-3163 Nasopharyngeal Carcinoma Using whole-transcript expression arrays and bioinformatic analysis, we identified scinderin (SCIN) and miR-3163 as potential downstream targets of MEX3A in NPC. In summary, our results demonstrate that MEX3A may promote NPC development and progression via the miR-3163/SCIN axis by regulating NF-kappaB signaling, thus providing a potential target for NPC treatment. +other 35490164 hsa-mir-20a Colonic Neoplasms 5p and miR-20a-5p are independent predictors of favorable prognosis. +other 35490164 hsa-mir-17 Colonic Neoplasms 5p and miR-20a-5p are independent predictors of favorable prognosis. +other 35489420 hsa-mir-199a Cardiovascular Diseases Our findings point to an important role for miR-199a-3p in the early stage of cardiovascular disease. +lncRNA target 35489420 hsa-mir-199a Inflammation CONCLUSIONS: Our results suggested that miR-199a-3p suppressed endothelial inflammation and adhesion by targeting mTOR signaling and increasing autophagy. +other 35489290 hsa-mir-196b Endometritis As a result, we found miR-196b up-regulated in the endometritis tissue and the high concentration lipopolysaccharide (LPS)-stimulated bovine endometrial epithelial (BEND) cell line, but down-regulated in the low concentration. +lncRNA target 35489022 hsa-mir-142 Ovarian Neoplasms 3p and its targets gene FAM83D may be potential diagnostic and prognostic biomarkers for patients with OC. +lncRNA target 35488374 hsa-let-7f Carcinoma, Non-Small-Cell Lung Then the relative gene and protein expressions of let-7f and its target genes, including HMGA2, ARID3B, SMARCAD1, and FZD3, were measured in lung tissues of NSCLC patients and A549 cell line using qRT-PCR and Western blotting. +other 35488248 hsa-mir-93 Ventricular Dysfunction, Right 5p have potential value in the diagnosis of CTEPH based on the correlation between the abnormal expression of these miRNAs and echocardiographic parameters in CTEPH patients. +other 35488248 hsa-mir-17 Ventricular Dysfunction, Right 5p have potential value in the diagnosis of CTEPH based on the correlation between the abnormal expression of these miRNAs and echocardiographic parameters in CTEPH patients. +other 35488248 hsa-mir-20a Ventricular Dysfunction, Right 5p individually (P = 0.0337 and 0.0453, respectively). +lncRNA target 35488217 hsa-mir-17 Osteochondritis Dissecans CONCLUSION: DEX inhibits OGD/R-induced inflammation and apoptosis in PC12 cells by increasing miR +other 35488128 hsa-mir-182 Cardiotoxicity 5p could serve as a potential biomarker of structural cardiotoxicity and/or an additional endpoint to characterize cardiac injury in vitro. +other 35488128 hsa-mir-187 Cardiotoxicity 5p could serve as a potential biomarker of structural cardiotoxicity and/or an additional endpoint to characterize cardiac injury in vitro. +exosome 35488079 hsa-let-7e Alzheimer Disease Our study suggests that sNDEV-resident let-7e is a potential biomarker for AD diagnosis, and that AD patient-derived sNDEVs induce a neuroinflammatory response in microglia. +circulation_biomarker_diagnosis_ns 35487317 hsa-mir-21 Tetralogy of Fallot METHODS: Serum biomarkers [metalloproteinases MMP1 and MMP9, galectin-3, micro-RNA21 (miR21)), ST2, procollagen type I carboxy-terminal propeptide (PICP), and NTproBNP] were measured in TOF patients undergoing CMR. +circulation_biomarker_diagnosis_ns 35487317 hsa-mir-21 Cardiomyopathies METHODS: Serum biomarkers [metalloproteinases MMP1 and MMP9, galectin-3, micro-RNA21 (miR21)), ST2, procollagen type I carboxy-terminal propeptide (PICP), and NTproBNP] were measured in TOF patients undergoing CMR. +other 35487268 hsa-mir-155 Breast Neoplasms MiR-21 and miR-155 are two significant biomarkers that act as oncomir in breast cancer. +other 35487268 hsa-mir-21 Breast Neoplasms MiR-21 and miR-155 are two significant biomarkers that act as oncomir in breast cancer. +other 35487029 hsa-mir-129 Stomach Neoplasms In addition, two constructed regulatory axes (include FAM66C/miR5p/7 mRNAs and SFTA1P/miR-206/FN1 or NRP1) were successfully validated by the Genomic Data Commons (GDC) GC data. +other 35487029 hsa-mir-206 Stomach Neoplasms In addition, two constructed regulatory axes (include FAM66C/miR5p/7 mRNAs and SFTA1P/miR-206/FN1 or NRP1) were successfully validated by the Genomic Data Commons (GDC) GC data. +lncRNA target 35487027 hsa-mir-193a Adenocarcinoma of Lung The last rescue assays displayed that SNHG11 affecting LUAD cell malignant behaviors via regulating miR-193a-5p/SNHG11. CONCLUSION: SNHG11 regulated miR-193a-5p/Notch3 axis to activate Notch pathway, consequently facilitating the proliferation and migration in LUAD. +other 35486965 hsa-mir-1a Pulmonary Fibrosis Further research found that attenuation of miR-1a-3p plays an important role in TWMP-induced lung injury. +genetics_overexpression_promote 35486941 hsa-mir-873 Thyroid Neoplasms 5p on TC cells was abolished through CXCL5 overexpression. +other 35486636 hsa-mir-21 Uterine Cervical Neoplasms Previous work has demonstrated that the expression of microRNA-21 (miR-21) is implicated in cervical cancer (CC). In this study, bioinformatic tools and meta-analysis validated that miR-21 may function as a highly sensitive and specific marker for the diagnosis of CC, which may provide a novel approach to the diagnosis and treatment of CC. +other 35486353 hsa-mir-128 Neurotoxicity Syndromes 3p. +lncRNA target 35486287 hsa-mir-128 Breast Neoplasms 3p mimics in suppressing EMT of breast cancer cell lines by regulating the TGF-beta1/SP1 axis. +other 35486213 hsa-mir-96 Glioblastoma Comparison of miR profiles of EGFR-amplified and EGFR-normal GBM revealed an upregulation of the miR-183/96/182 cluster, which is associated with oncogenic properties in several tumor entities. By observing FOXO1 downregulation in EGFR-amplified tumors, we can see a significant correlation of EGFR amplification, miR-183/96/182 cluster upregulation, and repression of FOXO1. +other 35486213 hsa-mir-182 Glioblastoma Comparison of miR profiles of EGFR-amplified and EGFR-normal GBM revealed an upregulation of the miR-183/96/182 cluster, which is associated with oncogenic properties in several tumor entities. By observing FOXO1 downregulation in EGFR-amplified tumors, we can see a significant correlation of EGFR amplification, miR-183/96/182 cluster upregulation, and repression of FOXO1. +other 35486213 hsa-mir-183 Glioblastoma Comparison of miR profiles of EGFR-amplified and EGFR-normal GBM revealed an upregulation of the miR-183/96/182 cluster, which is associated with oncogenic properties in several tumor entities. By observing FOXO1 downregulation in EGFR-amplified tumors, we can see a significant correlation of EGFR amplification, miR-183/96/182 cluster upregulation, and repression of FOXO1. +genetics_GWAS 35485699 hsa-mir-34b Carcinoma, Hepatocellular OBJECTIVE: We aimed to demonstrate the frequency of miRNA 196a2 rs11614913 and miRNA 34 b/c rs4938723 gene polymorphisms in HCC patients and their correlation with the clinical features and laboratory findings at diagnosis. CONCLUSIONS: This study identified miR-196a2 rs11614913 CC genotype as a risk factor for HCC development while we failed to document similar relation for miR-34b/c rs4938723 polymorphism. +other 35485699 hsa-mir-196a-2 Carcinoma, Hepatocellular RESULTS: HCC patients had significantly higher frequency of miR2a rs11614913 CC genotype when compared with cirrhotic patients (60.0 % versus 30.0 %, p=0.013). +lncRNA target 35485648 hsa-mir-876 Endometrial Neoplasms 5p/HKDC1 signal transduction axis in EC cell pyroptosis at the molecular level, which may provide an effective therapeutic target for patients with diabetes who are diagnosed with EC. +circulation_biomarker_diagnosis_ns 35485364 hsa-mir-199 Osteoarthritis In conclusion, LINC00707 can be detected in cytoplasm and it may sponge miR +genetics_overexpression_promote 35485355 hsa-mir-2392 Carcinoma, Hepatocellular Overexpression of miR-2392 suppressed proliferation, clonogenicity, mobility, spheroid formation and maintenance of cancer stem cells (CSC)-like characteristics in HCC cells. +exosome 35485349 hsa-mir-34a Squamous Cell Carcinoma of Head and Neck Here, we aimed to explore whether exosomes could be used to load microRNA-34a via co-incubation and further used to treat OSCC. +transcription factor target 35485293 hsa-mir-497 Carcinoma, Non-Small-Cell Lung 5p mimic and inhibitor were, respectively, transfected into human NSCLC cells A549 and H460, CCK-8 assay, transwell assay, and flow cytometry were used to detect the capacities of cell proliferation, invasion and apoptosis. +lncRNA target 35485286 hsa-mir-143 Fibrosis, Renal Thus, targeting CCL20 by miR5p could alleviate renal fibrosis progression by regulating fibroblast proliferation and ECM deposition via the Smad2/3 and AKT signaling, providing a potential therapeutic target for environmental lead contamination-evoked fibrotic kidney disease. +genetics_overexpression_promote 35485281 hsa-mir-4730 Liver Neoplasms The effects of miR4730 overexpression were examined in LC cell lines, and the target genes of miR4730 were evaluated using microarray analysis and TargetScan data. +transcription factor target 35485239 hsa-mir-1 Heart Failure This processing is limited in HFrEF patients via the downregulation of proANP production, corin, and meprin B activities by miR-425 and miR1-3p. +transcription factor target 35485239 hsa-mir-425 Heart Failure This processing is limited in HFrEF patients via the downregulation of proANP production, corin, and meprin B activities by miR-425 and miR1-3p. +lncRNA target 35485164 hsa-mir-125b Carcinoma, Hepatocellular LINC00978/microRNA-125b-5p/SOX12 axis promoted liver cancer migration, invasion, and proliferation, which could be used as a possible therapeutic target for the treatment of hepatocellular carcinoma. +circulation_biomarker_prognosis_up 35485050 hsa-mir-4429 Carcinoma, Non-Small-Cell Lung RESULT: The expression of LINC00313 was significantly up-regulated while the expression of miR-4429 was down-regulated in NSCLC serum, tissue and cell lines. +circRNA target 35484994 hsa-mir-212 Carcinoma, Hepatocellular circ_0003528 contributes to the development of HCC in vitro and in vivo via the miR +other 35484886 hsa-mir-29a Hypopharyngeal Neoplasms CONCLUSION: MiR-29a-3p and Cdc42 mRNA could be potential diagnostic biomarkers of hypopharyngeal carcinoma. +lncRNA target 35484885 hsa-mir-34a Carcinoma, Hepatocellular CONCLUSION: These results suggest that miR-34a-5p could inhibit the occurrence and development of HCC by targeting VEGFA. +circRNA target 35484574 hsa-mir-34c Nasopharyngeal Carcinoma RESULTS: CircCRIM1 and FOSL1 were upregulated in NPC cells, while miR-34c-5p was downregulated. The miR-34c-5p inhibitor notably promoted the malignant behaviour of NPC cells, while miR-34c-5p mimics exerted the opposite effect. +lncRNA target 35484565 hsa-mir-642a Gallbladder Neoplasms 5p were identified as invasion-metastasis associated miRNAs via bioinformatics and experimental validation, and both up-regulation of miR-642a-3p and down-regulation of miR +lncRNA target 35484565 hsa-mir-145 Gallbladder Neoplasms 5p were identified as invasion-metastasis associated miRNAs via bioinformatics and experimental validation, and both up-regulation of miR-642a-3p and down-regulation of miR +other 35484551 hsa-mir-486 Pulmonary Fibrosis To investigate the molecular mechanism of how radiation induces pulmonary fibrosis by altering miR3p content and thus inducing EMT. +exosome 35484432 hsa-mir-17 Liver Cirrhosis CONCLUSION: hMSCs-derived exosome circCDK13 inhibited liver fibrosis by regulating the expression of MFGE8 through miR +other 35484171 hsa-mir-369 COVID-19 In conclusion, miR3p was altered in patients with mechanical ventilation requirement in comparison with COVID-19 patients without this requirement. +other 35484171 hsa-mir-369 Respiratory Distress Syndrome In conclusion, miR3p was altered in patients with mechanical ventilation requirement in comparison with COVID-19 patients without this requirement. +genetics_GWAS 35484165 hsa-mir-26a Upper Tract Urothelial Carcinoma BFTC-909 UTUC cells were used to examine the effects of miR-26a-5p genetic delivery on proliferation, migration and expression of epithelial-to-mesenchymal transition (EMT) markers. +other 35484121 hsa-mir-766 Osteoarthritis Expression of circ_0000205 was up-regulated in OA tissues and IL-1beta-induced primary chondrocytes, accompanied with miR3p down-regulation and ADAMTS5 up-regulation. +genetics_overexpression_promote 35484046 hsa-mir-34a Colorectal Neoplasms Overexpression of AK077216 inhibited CRA cell migration and invasion, while overexpression of miR-34a accelerated cancer cell migration and invasion and attenuated the effects of overexpression on AK077216 on cell behaviors. +genetics_overexpression_promote 35483716 hsa-mir-155 psoriasis 1 Previously, we found that MSCs from psoriatic lesions overexpress the proinflammatory microRNA, miR-155 and exhibit a decreased immunosuppressive capacity. +other 35483451 hsa-mir-27b Hepatitis C The miRNA miR-27b is known to regulate lipid regulatory pathways in the human liver and is also induced by the hepatitis C virus (HCV). +lncRNA target 35483343 hsa-mir-569 Pancreatic Carcinoma These data demonstrated that microRNA-569 may exert a tumor-suppressing effect in PC and maybe a potential therapeutic target for PC patients. +genetics_knock down_promote 35483305 hsa-mir-4487 Angelman Syndrome Also, RASA1 knockdown reversed the effects of miR-4487 inhibition on VSMCs. +other 35483234 hsa-mir-200b Inflammation Our findings suggest a crucial role for the miR-200b-3p/FSTL1 axis in regulating asthmatic's airway remodeling and inflammation phenotype. +other 35483234 hsa-mir-200b Asthma Our findings suggest a crucial role for the miR-200b-3p/FSTL1 axis in regulating asthmatic's airway remodeling and inflammation phenotype. +lncRNA target 35482822 hsa-mir-516b Carcinoma, Non-Small-Cell Lung Circ-OXCT1 promoted SLC1A5 expression by target binding with miR-516b-5p.Circ-OXCT1 facilitated NSCLC progression via miR-516b-5p-dependent regulation of SLC1A5, which provided a possible circRNA-targeted therapy for NSCLC. +other 35482720 hsa-mir-101 Carcinoma, Hepatocellular 3p/SNX16/PAPOLG axis of the ceRNA network axis might be an important factor associated with HCC prognosis and immune infiltration. +lncRNA target 35482482 hsa-mir-378a Acute Kidney Injury In conclusion, lncRNA136131 protected against I/R-induced AKI progression by targeting miR-378a-3p/Rab10 and may be utilized as a novel target for AKI therapeutics. +genetics_knock down_suppress 35482475 hsa-mir-151 Diabetic Nephropathies CONCLUSION: CircNUP98 knockdown alleviates HG-induced proliferation, fibrosis inflammation and oxidative stress in HMCs by regulating the miR3p-HMGA2 axis, which might provide a potential approach for DN therapeutics. +genetics_knock down_suppress 35482475 hsa-mir-151 Inflammation CONCLUSION: CircNUP98 knockdown alleviates HG-induced proliferation, fibrosis inflammation and oxidative stress in HMCs by regulating the miR3p-HMGA2 axis, which might provide a potential approach for DN therapeutics. +other 35482409 hsa-mir-10b fibrolamellar carcinoma We identified miR-10b-5p as the top candidate pro-proliferative microRNA in FLC. +other 35482130 hsa-mir-665 Ischemic Stroke The expression levels of hsa_circ_0010729, miR-665, and ING5 in ischemic stroke were detected by quantitative real-time polymerase chain reaction (qRT-PCR). +other 35482130 hsa-mir-665 Stroke The expression levels of hsa_circ_0010729, miR-665, and ING5 in ischemic stroke were detected by quantitative real-time polymerase chain reaction (qRT-PCR). +lncRNA target 35481944 hsa-mir-124 Brain Injuries, Traumatic Moreover, the combined use of BDNF and miR-124 inhibitors might lead to better outcomes in TBI than BDNF treatment alone. +lncRNA target 35481549 hsa-mir-214 Parkinson Disease Further analyses revealed that MPP(+) inhibited cell viability; enhanced cell apoptosis, Cleaved Caspase-3 expression and Cleaved Caspase-3/GAPDH ratio; induced oxidative stress and inflammation in SH-SY5Y cells were inhibited by lncRNA BACE1-AS-siRNA transfection; and all these inhibitions were reversed by miR +lncRNA target 35481488 hsa-mir-378b Fatty Liver This work aimed to clarify further mechanism of CADE in improving hepatic lipid accumulation in ALD through the microRNA-378b (miR-378b)-mediated Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2)-AMPK signaling pathway. MiR-378b escalation exacerbated hepatic steatosis and inhibited CaMKK2-AMPK signaling, while miR-378b deficiency alleviated lipid accumulation and activated the CaMKK2 cascade. +lncRNA target 35481488 hsa-mir-378b Alcoholism This work aimed to clarify further mechanism of CADE in improving hepatic lipid accumulation in ALD through the microRNA-378b (miR-378b)-mediated Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2)-AMPK signaling pathway. MiR-378b escalation exacerbated hepatic steatosis and inhibited CaMKK2-AMPK signaling, while miR-378b deficiency alleviated lipid accumulation and activated the CaMKK2 cascade. +circRNA target 35481460 hsa-mir-1299 Squamous Cell Carcinoma of Head and Neck Inhibition of the circGOLPH3/miR-1299/LIF axis suppressed the growth, migration, and invasion of OSCC cells. These findings indicate that the circGOLPH3/miR-1299/LIF axis promotes OSCC cell growth, migration, and invasion and that this axis is a potential therapeutic target for OSCC. +genetics_overexpression_promote 35481453 hsa-mir-381 Inflammation MiR3p suppressed LPS-induced WI-38 cell inflammatory injury, and this effect was revoked by TRAF3 overexpression. +genetics_knock down_promote 35481447 hsa-mir-9 Stomach Neoplasms CONCLUSIONS: These results suggested that NFIC was highly expressed in gastric cancer cells, and knockdown of NFIC suppressed the growth and mobility of gastric cancer cells; miR +transcription factor target 35481399 hsa-mir-4287 Osteoarthritis In conclusion, miR-4287 is a critical molecule in OA development, which attenuates inflammatory response in vivo and in vitro by targeting RIPK1. +genetics_overexpression_promote 35481398 hsa-mir-374b Iris Diseases Overexpression of MEF2D activated the Wnt/beta-catenin pathway and attenuated the supporting effects of miR-374b-5p on renal IRI. +genetics_overexpression_promote 35481398 hsa-mir-374b Nephritis, Interstitial Overexpression of MEF2D activated the Wnt/beta-catenin pathway and attenuated the supporting effects of miR-374b-5p on renal IRI. CONCLUSION: Sev promotes MEF2D and activates the Wnt/beta-catenin pathway through inhibition of miR-374b-5p expression to affect renal IRI. +other 35481271 hsa-mir-135b Ischemic Cerebral Infarction 5p/hsa-miR-3135b may regulate the REL/SOD2 pathway in ICI progression. +other 35481271 hsa-mir-518 Ischemic Cerebral Infarction 5p/hsa-miR-3135b may regulate the REL/SOD2 pathway in ICI progression. +lncRNA target 35480984 hsa-mir-760 Intervertebral Disc Degeneration Therefore, miR-760 was found to play an important role in IDD and can be used as a promising therapeutic target for the treatment of patients with IDD. +other 35480884 hsa-mir-27b nonpapillary renal cell carcinoma 5p/CCNA2) by expression analysis, survival analysis, and correlation analysis. +other 35480884 hsa-mir-27b Carcinoma, Hepatocellular 5p/CCNA2) by expression analysis, survival analysis, and correlation analysis. +other 35480884 hsa-mir-22 Adenocarcinoma of Lung 5p/CCNA2) by expression analysis, survival analysis, and correlation analysis. +other 35480884 hsa-mir-22 Carcinoma, Hepatocellular 5p/CCNA2) by expression analysis, survival analysis, and correlation analysis. +other 35480884 hsa-mir-27b Adenocarcinoma of Lung 5p/CCNA2) by expression analysis, survival analysis, and correlation analysis. +other 35480884 hsa-mir-22 nonpapillary renal cell carcinoma 5p/CCNA2) by expression analysis, survival analysis, and correlation analysis. +transcription factor target 35480873 hsa-mir-874 Intervertebral Disc Degeneration 3p in IDD, thereby relieving the inhibition of ATF3 by miR +lncRNA target 35480871 hsa-mir-122 Osteoarthritis Taken altogether, BMSC-EVs containing NEAT1 activated the Sesn2/Nrf2 axis via binding to miR +target gene 35480301 hsa-mir-107 Stomach Neoplasms miR-107 Inhibits the Proliferation of Gastric Cancer Cells In vivo and In vitro by Targeting TRIAP1. +other 35480196 hsa-mir-21 Heart Failure MicroRNA 21 (miRNA-21) is reported to be closely associated with the development of heart failure, cardiac fibrosis and hypertrophy, which could be a promising biomarker for the early-diagnosis of heart failure. +genetics_knock down_promote 35480113 hsa-mir-124a Melanoma miR-124a overexpression did not inhibit tumor growth in vivo, underscoring that miR-124a specifically controls processes required for melanoma metastatic growth, such as seeding and growth post-extravasation. +other 35478990 hsa-mir-933 Carcinoma, Hepatocellular METHODS: The level of TFAP2A-AS1 and miR-933 in HCC cell and samples were detected by qRT-PCR assay. However, miR-933 was upregulated in HCC cell lines and HBV-infected HCC samples compared with nontumor tissues, and miR-933 was negatively associated with the expression of TFAP2A-AS1 in HBV-correlated HCC samples. +circulation_biomarker_diagnosis_up 35478972 hsa-mir-146a Atherosclerosis The results indicated that by comparison with the HH group, the treatment with EVs(ADSCs) or EVs(MSCs) alone or in combination with Smad2/3siRNA of HH animals induced a significant decrease in the main plasma parameters and a noticeable improvement in the structure and function of the thoracic aorta and carotid artery along with a decrease in the selected molecular and cellular targets mediating their changes in atherosclerosis: 1) a decrease in expression of structural and inflammatory markers COL1A1, alpha-SMA, Cx43, VCAM-1, and MMP-2; 2) a slight infiltration of total/M1 macrophages and T-cells; 3) a reduced level of cytosolic ROS production; 4) a significant diminution in plasma concentrations of TGF-beta1 and Ang II proteins; 5) significant structural and functional improvements (thinning of the arterial wall, increase of the inner diameter, enhanced distensibility, diminished VTI and Vel, and augmented contractile and relaxation responses); 6) a reduced protein expression profile of Smad2/3, ATF-2, and NF-kBp50/p65 and a significant decrease in the expression levels of miR-21, miR-29a, miR-192, miR-200b, miR-210, and miR-146a. +other 35478963 hsa-mir-29b Heart Diseases, Congenital In this study, we found that miR-29b-3p expression was inversely correlated with DNMT expression in the heart tissues of patients with congenital heart disease (CHD), but whether it interacts with DNMTs in cardiomyocytes remains unknown. +genetics_knock down_promote 35478295 hsa-mir-497 Diabetic Neuropathies Using gain- and loss-of-function assays, we analyzed the critical role of miR +genetics_GWAS 35478113 hsa-mir-145 Aortic Aneurysm, Abdominal Literature indicates that the differentially expressed miRNA-145 in patients' serum is an essential biomarker for abdominal aortic aneurysm (AAA). However, the correlation between specific miR-145 genetic polymorphisms with AAA susceptibility is inadequately studied. +tissue_expression_ns 35478111 hsa-mir-1 Breast Neoplasms CONCLUSION: MiR-31 was expressed at low levels in BC tissues and correlated with adverse clinical and pathological features, and poor survival. +lncRNA target 35477946 hsa-mir-21 Diabetes Mellitus, Type 2 We built a TF-miRNA-mRNA regulatory network to reveal the novel mechanism (miRPPARA-NCOA6) of dysregulated keratinocyte proliferation, differentiation, and migration in diabetic skin, which may provide new insights into the susceptibility of skin disorders in T2DM patients. +lncRNA target 35477702 hsa-mir-625 Colonic Neoplasms It is summarized that down-regulated LINC00511 obstructs tumorigenesis of CC through restoring miR +transcription factor target 35477552 hsa-mir-146a Diabetic Nephropathies Mechanistically, miR-146a-5p was significantly downregulated and negatively correlated with renal injury in DN rats as determined through high-throughput RNA sequencing. +circulation_biomarker_diagnosis_up 35477546 hsa-mir-491 Atherosclerosis 5p was abnormally expressed in the plaques and serum from AS patients. +other 35477450 hsa-mir-100 Uterine Cervical Neoplasms CircCASC15-miR-100-mTOR may influence the cervical cancer radioresistance. +circulation_biomarker_diagnosis_ns 35477045 hsa-mir-486 Pre-Eclampsia 5p was reportedly increased within exosomes derived from maternal circulation in preeclamptic pregnancy. +circRNA target 35477026 hsa-mir-20b Diabetic Retinopathy CONCLUSION: Circ_NNT protected ARPE-19 cells against HG-evoked apoptosis and inflammation via elevating TIMP3 through sequestering miR-320b, indicating that up-regulation of circ_NNT might contribute to the inhibition of DR process. +other 35477008 hsa-mir-1915 Hepatitis B, Chronic TSPEAR-AS1 may bind to miR5p in HCC. +other 35476966 hsa-mir-132 Alzheimer Disease 3p, miR-146a-5p, miR-29a-3p, and miR-30a-5p in the AD brain are associated with amyloid-beta (Abeta) aggregation, tau pathology, neuroinflammation, and synaptic dysfunction, the major pathological hallmarks of Alzheimer's disease)AD(. +other 35476966 hsa-mir-146a Alzheimer Disease 3p, miR-146a-5p, miR-29a-3p, and miR-30a-5p in the AD brain are associated with amyloid-beta (Abeta) aggregation, tau pathology, neuroinflammation, and synaptic dysfunction, the major pathological hallmarks of Alzheimer's disease)AD(. +other 35476966 hsa-mir-124 Alzheimer Disease 3p, miR-146a-5p, miR-29a-3p, and miR-30a-5p in the AD brain are associated with amyloid-beta (Abeta) aggregation, tau pathology, neuroinflammation, and synaptic dysfunction, the major pathological hallmarks of Alzheimer's disease)AD(. +other 35476966 hsa-mir-26a Alzheimer Disease 3p, miR-146a-5p, miR-29a-3p, and miR-30a-5p in the AD brain are associated with amyloid-beta (Abeta) aggregation, tau pathology, neuroinflammation, and synaptic dysfunction, the major pathological hallmarks of Alzheimer's disease)AD(. +other 35476966 hsa-mir-181b Alzheimer Disease In conclusion, our study suggest that the neuroprotective effects of insulin on memory observed in AD-like rats could be partially due to the restoration of miR-132, miR-181b, and miR-125b expression in the brain. +other 35476966 hsa-mir-29a Alzheimer Disease 3p, miR-146a-5p, miR-29a-3p, and miR-30a-5p in the AD brain are associated with amyloid-beta (Abeta) aggregation, tau pathology, neuroinflammation, and synaptic dysfunction, the major pathological hallmarks of Alzheimer's disease)AD(. +other 35476966 hsa-mir-125b Alzheimer Disease In conclusion, our study suggest that the neuroprotective effects of insulin on memory observed in AD-like rats could be partially due to the restoration of miR-132, miR-181b, and miR-125b expression in the brain. +transcription factor target 35476233 hsa-mir-144 Colorectal Neoplasms The miR-144/NUDCD1/IGF1R-ERK1/2 signaling axis may be crucial in the progression of CRC. +other 35475887 hsa-mir-29a Keratitis, Herpetic 5p were significantly upregulated in patients with HEK. +other 35475887 hsa-mir-155 Keratitis, Herpetic 5p were significantly upregulated in patients with HEK. +other 35475887 hsa-mir-23b Keratitis, Herpetic 5p were significantly upregulated in patients with HEK. +other 35475887 hsa-mir-146b Keratitis, Herpetic 5p were significantly upregulated in patients with HEK. +other 35475887 hsa-mir-92a Keratitis, Herpetic 5p were significantly upregulated in patients with HEK. +other 35475887 hsa-mir-16 Keratitis, Herpetic 5p were significantly upregulated in patients with HEK. +other 35475887 hsa-mir-25 Keratitis, Herpetic 5p were significantly upregulated in patients with HEK. +other 35475887 hsa-mir-20b Keratitis, Herpetic 5p were significantly upregulated in patients with HEK. +other 35475887 hsa-mir-223 Keratitis, Herpetic 5p were significantly upregulated in patients with HEK. +other 35475887 hsa-mir-221 Keratitis, Herpetic 5p were significantly upregulated in patients with HEK. +other 35475887 hsa-mir-338 Keratitis, Herpetic 5p were significantly upregulated in patients with HEK. +other 35475887 hsa-mir-146a Keratitis, Herpetic 5p were significantly upregulated in patients with HEK. +other 35475887 hsa-mir-15b Keratitis, Herpetic 5p were significantly upregulated in patients with HEK. +transcription factor target 35475886 hsa-mir-34 Corneal Endothelium Failure CONCLUSIONS: The upregulated expression of CD44, through repressed miR-34a/b by reactive oxygen species and elevated c-Myc by oxidative stress, may impair mitochondrial metabolic homeostasis, leading to human corneal endothelial failure. +transcription factor target 35475886 hsa-mir-34a Corneal Endothelium Failure CONCLUSIONS: The upregulated expression of CD44, through repressed miR-34a/b by reactive oxygen species and elevated c-Myc by oxidative stress, may impair mitochondrial metabolic homeostasis, leading to human corneal endothelial failure. +transcription factor target 35475886 hsa-mir-34b Corneal Endothelium Failure CONCLUSIONS: The upregulated expression of CD44, through repressed miR-34a/b by reactive oxygen species and elevated c-Myc by oxidative stress, may impair mitochondrial metabolic homeostasis, leading to human corneal endothelial failure. +genetics_knock down_promote 35475590 hsa-mir-15b Esophageal Squamous Cell Carcinoma The effects of hsa_circ_0039929 knockdowns on PI3K/AKT pathways and EMT progress resembled the hsa-miR-15b-3p_R-1 overexpression. +other 35475590 hsa-mir-15b Inflammation All above suggested that ceRNA hsa_circ_0039929/hsa-miR-15b-3p_R-1/FGF2 played an important role in the inflammation and EMT caused by LMW-PAHs. +lncRNA target 35475502 hsa-mir-216b Lung Neoplasms In brief, LINC01578 suppresses miR-216b-5p and enhances TBL1XR1 expression, thus to promote biological functions of radiation-resistant NSCLC cells. +other 35475470 hsa-mir-96 Carcinoma, Hepatocellular In conclusion, lncRNA PLAC2 negatively regulates the chemosensitivity of HCC cells to cisplatin, possibly by sponging miR-96 to upregulate miR-96. +lncRNA target 35475457 hsa-mir-577 Carcinoma, Non-Small-Cell Lung In contrast, miR-577, which was a downstream target of RFX3-AS1, dramatically impeded the malignant biological behaviors of NSCLC cells. In brief, RFX3-AS1 aggravated NSCLC progression by regulating the miR-577/STAT3 axis. +other 35475453 hsa-mir-498 Urinary Bladder Neoplasms In conclusion, our study showed that circMCTP2 regulates the expression of MDM2 by sponging miR-498 to promote the development of BC. +genetics_overexpression_promote 35475447 hsa-mir-1301 Stomach Neoplasms In addition, miR13013p was regulated by circ_0067934, and miR13013p overexpression suppressed GC cell migration, invasion and proliferation. +genetics_knock down_suppress 35475415 hsa-mir-367 Myocardial Ischemia circ_0000080 knockdown alleviated myocardial hypoxia injury through the miR5p/COX2 axis. +circulation_biomarker_diagnosis_ns 35475253 hsa-mir-21 Uterine Cervical Neoplasms Using miRNA expression data in the public domain, we identified miR5p and miR-20a-5p as blood-based miRNA biomarkers specific to early-stage cervical cancer employing a multi-tier algorithmic screening. +circulation_biomarker_diagnosis_ns 35475253 hsa-mir-20a Uterine Cervical Neoplasms Using miRNA expression data in the public domain, we identified miR5p and miR-20a-5p as blood-based miRNA biomarkers specific to early-stage cervical cancer employing a multi-tier algorithmic screening. +lncRNA target 35475028 hsa-mir-146a Hypertrophy Therefore, this translational study determined the effectiveness of a hUCMSC-EVs-based approach for the treatment of LFH and revealed the critical target of miR-146a-5p and miR3p. +lncRNA target 35475028 hsa-mir-221 Hypertrophy Therefore, this translational study determined the effectiveness of a hUCMSC-EVs-based approach for the treatment of LFH and revealed the critical target of miR-146a-5p and miR3p. +lncRNA target 35474736 hsa-mir-378 Osteoarthritis In conclusion, miR-378 amplified OA development via repressing chondrocyte autophagy and by inhibiting BMSCs chondrogenesis, thus indicating miR-378 may be a potential therapeutic target for OA treatments. +lncRNA target 35474604 hsa-mir-1261 Adenocarcinoma of Lung CONCLUSIONS: Circ_0072088-dependent regulation of miR-1261/PIK3CA is important for cell proliferation, migration, and invasion during the tumorigenesis and progression of LUAD, warranting the need to consider the circ_0072088/miR-1261/PIK3CA regulatory pathway as a potential therapeutic target in patients with lung adenocarcinoma. +genetics_overexpression_suppress 35474406 hsa-mir-145 Squamous Cell Carcinoma of Head and Neck 5p could repress LSCC progression, and OTX1 overexpression also eliminated this effect. +other 35474387 hsa-mir-34a Esophageal Squamous Cell Carcinoma In analyzable cancer types, miR-34a does not appear to be down-regulated in primary tumors relatively to normal adjacent tissues. +genetics_overexpression_promote 35474040 hsa-mir-671 Glioma METTL3 overexpression repressed the malignant proliferation of glioma via circDLC1/miR +transcription factor target 35473892 hsa-mir-888 Carcinoma, Hepatocellular RESULTS Compared with patients with HCC treated with sorafenib, patients treated with lenvatinib developed 8 differentially expressed genes (DEGs, FGF4, FGF23, UNC13C, RIMBP2, STXBP5L, PHOX2B, NEUROD4, and POU4F2) and 3 miRNAs (DEMs, has-miR-548ah, has-miR-888, and has-miR-196a-1), of which hsa-miR-548 regulated 4 target genes, the largest number among the 3 miRNAs. +transcription factor target 35473892 hsa-mir-548 Carcinoma, Hepatocellular RESULTS Compared with patients with HCC treated with sorafenib, patients treated with lenvatinib developed 8 differentially expressed genes (DEGs, FGF4, FGF23, UNC13C, RIMBP2, STXBP5L, PHOX2B, NEUROD4, and POU4F2) and 3 miRNAs (DEMs, has-miR-548ah, has-miR-888, and has-miR-196a-1), of which hsa-miR-548 regulated 4 target genes, the largest number among the 3 miRNAs. +transcription factor target 35473892 hsa-mir-196a-1 Carcinoma, Hepatocellular RESULTS Compared with patients with HCC treated with sorafenib, patients treated with lenvatinib developed 8 differentially expressed genes (DEGs, FGF4, FGF23, UNC13C, RIMBP2, STXBP5L, PHOX2B, NEUROD4, and POU4F2) and 3 miRNAs (DEMs, has-miR-548ah, has-miR-888, and has-miR-196a-1), of which hsa-miR-548 regulated 4 target genes, the largest number among the 3 miRNAs. +transcription factor target 35473892 hsa-mir-548ah Carcinoma, Hepatocellular RESULTS Compared with patients with HCC treated with sorafenib, patients treated with lenvatinib developed 8 differentially expressed genes (DEGs, FGF4, FGF23, UNC13C, RIMBP2, STXBP5L, PHOX2B, NEUROD4, and POU4F2) and 3 miRNAs (DEMs, has-miR-548ah, has-miR-888, and has-miR-196a-1), of which hsa-miR-548 regulated 4 target genes, the largest number among the 3 miRNAs. +other 35473752 hsa-mir-1 Carcinoma, Non-Small-Cell Lung 5p/SP1 axis and the complex regulatory loops influence NSCLC progression. +other 35473687 hsa-mir-221 Carcinoma, Hepatocellular Furthermore, both let7-g and miR-221 may be potential biomarkers for the outcomes of HCC patients. +other 35473680 hsa-mir-223 Acute Lung Injury CONCLUSION: In general, our work illustrates that sevoflurane regulates the LINC00839/miR-223/NLRP3 axis to ameliorate LPS-induced ALI, which might provide a novel promising candidate for the prevention of ALI. +lncRNA target 35473552 hsa-mir-655 Adenocarcinoma of Lung In conclusion, this study demonstrated that EBLN3P silencing inhibits bioactivity and induces apoptosis via the miR3p/Bcl-2 axis, providing a potential therapeutic target for lung adenocarcinoma. +other 35473531 hsa-mir-22 Heart Failure, Chronic CONCLUSION: MicroRNAs -22, -92a, and -499 are differentially expressed in chronic and acute HF subjects. +other 35473531 hsa-mir-499 Heart Failure, Chronic CONCLUSION: MicroRNAs -22, -92a, and -499 are differentially expressed in chronic and acute HF subjects. +other 35473531 hsa-mir-92a Heart Failure, Chronic CONCLUSION: MicroRNAs -22, -92a, and -499 are differentially expressed in chronic and acute HF subjects. +lncRNA target 35473519 hsa-mir-483 Osteoporosis Furthermore, our research demonstrated that mitogen-activated protein kinase 1 (MAPK1) and SMAD family member 5 (Smad5) were direct targets of miR +transcription factor target 35473503 hsa-mir-126 Arthritis, Rheumatoid These results reveal that curcumin protects against RA by regulating the inc00052/miR5p/PIAS2 axis through JAK2/STAT3 signaling pathway. +lncRNA target 35472619 hsa-mir-100 Pulmonary Fibrosis The MIR100HG/miR-29a-3p/Tab1 axis could modulate TGF-beta1-induced fibrotic changes in type II alveolar epithelial cells and, thus, might be promising targets for pulmonary fibrosis therapy. +lncRNA target 35472619 hsa-mir-29a Pulmonary Fibrosis The MIR100HG/miR-29a-3p/Tab1 axis could modulate TGF-beta1-induced fibrotic changes in type II alveolar epithelial cells and, thus, might be promising targets for pulmonary fibrosis therapy. +genetics_overexpression_promote 35471684 hsa-mir-1290 Triple Negative Breast Neoplasms Moreover, the involvement of the miR-1290/NLRP3 axis in TNBC radioresistance was analyzed by experiments with a miR-1290 mimic and NLRP3 overexpression. +circulation_biomarker_diagnosis_up 35470961 hsa-mir-384 Alzheimer Disease RESULTS: The Abeta42, Abeta(42/40) , Tau, P-T181-tau, and miR-384 levels in NCAM single-labeled and NCAM/ABCA1 double-labeled exosomes of the aMCI and AD groups were significantly higher than those of the SCD, control, and vascular dementia (VaD) groups (all p < 0.05). The plasma NCAM/ABCA1 dual-labeled exosomal Abeta(42/40) and miR-384 had potential advantages in the diagnosis of SCD. +lncRNA target 35470783 hsa-mir-21 Breast Neoplasms The Kaplan-Meier analysis indicated that the patients with a high expression of miR-21, miR-20b, IGF1R, and E2F2 and a low expression of miR-125a, PDCD4, and PTEN had exhibited a shorter overall survival rate.Our results suggested that the underlying mechanisms of the lncRNA, miRs, and mRNAs and relevant signaling pathways may be considered predictive and therapeutic targets for breast cancer. +lncRNA target 35470783 hsa-mir-125a Breast Neoplasms The Kaplan-Meier analysis indicated that the patients with a high expression of miR-21, miR-20b, IGF1R, and E2F2 and a low expression of miR-125a, PDCD4, and PTEN had exhibited a shorter overall survival rate.Our results suggested that the underlying mechanisms of the lncRNA, miRs, and mRNAs and relevant signaling pathways may be considered predictive and therapeutic targets for breast cancer. +lncRNA target 35470783 hsa-mir-20b Breast Neoplasms The Kaplan-Meier analysis indicated that the patients with a high expression of miR-21, miR-20b, IGF1R, and E2F2 and a low expression of miR-125a, PDCD4, and PTEN had exhibited a shorter overall survival rate.Our results suggested that the underlying mechanisms of the lncRNA, miRs, and mRNAs and relevant signaling pathways may be considered predictive and therapeutic targets for breast cancer. +other 35470728 hsa-mir-139 Asthma 5p/TRIM8 axis, hinting at an underlying therapeutic strategy for asthma. +other 35469231 hsa-mir-139 Intracranial Aneurysm Despite further research being needed to determine the exact functions of miR5p in the formation of CA, our new findings contribute to a comprehensive understanding of the treatment mechanism of IA. +exosome 35468879 hsa-mir-21 Femur Head Necrosis 5p shuttled by hucMSC-Exos, in promoting angiogenesis and osteogenesis, which may be a potential therapeutic target for ONFH. +lncRNA target 35468741 hsa-mir-375 Colorectal Neoplasms CONCLUSIONS: LINC00022 may up-regulate FOXF1 expression via competitively binding miR3p, thereby promoting the development of CRC. +lncRNA target 35468721 hsa-mir-429 Carcinoma, Hepatocellular MiR-429 was validated to be the target of MAPKAPK5-AS1, and miR-429 inhibitors could partially offset the effects of knocking down MAPKAPK5-AS1 on HCC cells. +transcription factor target 35468468 hsa-mir-145 Lupus Nephritis CONCLUSION: Our data reveals that miR-145 regulates LN progression via CSF1 mediated JAK/STAT signaling pathway, and miR-145 may be a new therapeutic target for LN treatment. +other 35468339 hsa-mir-130a Prostatic Neoplasms Accordingly, in the present study, we aimed to reveal the clinical significance of miR-130a, miR-301a, miR-454 expression levels in formalin fixed paraffin embedded (FFPE) tissue samples of prostate cancer patients. Notably, we found that miR-301a and miR-454 were significantly upregulated whereas miR-130a were downregulated in cancerous tissues of prostate cancer patients compared to adjacent healthy tissue samples. +other 35468339 hsa-mir-454 Prostatic Neoplasms Accordingly, in the present study, we aimed to reveal the clinical significance of miR-130a, miR-301a, miR-454 expression levels in formalin fixed paraffin embedded (FFPE) tissue samples of prostate cancer patients. Notably, we found that miR-301a and miR-454 were significantly upregulated whereas miR-130a were downregulated in cancerous tissues of prostate cancer patients compared to adjacent healthy tissue samples. +genetics_knock down_promote 35468304 hsa-mir-4731 Stomach Neoplasms 5p inhibition and HOXC6 overexpression could reverse the biological behavior of GC cells induced by LINC01857 knockdown. +transcription factor target 35468097 hsa-mir-181a Esophageal Squamous Cell Carcinoma In short, repressed ERK-MMP pathway mediated by miR-181a-5p can inhibit cell migration, invasion and proliferation by targeting MAP2K1 (MEK1) in ESCC. +lncRNA target 35468096 hsa-mir-206 Depression These miRNAs can activate or inhibit the T cell receptor signal pathway, JAK-STAT and other signal pathways, govern immune-inflammatory response, neuronal remodeling, and mediate the onset and development of MMD Conclusions: The results of a thorough bioinformatics investigation of miRNAs and mRNAs in MDD showed that miR3P and miR-206 might be effective biomarkers and possible therapeutic targets for the treatment of MDD via nerve-immunity interaction. +lncRNA target 35468096 hsa-mir-338 Depression These miRNAs can activate or inhibit the T cell receptor signal pathway, JAK-STAT and other signal pathways, govern immune-inflammatory response, neuronal remodeling, and mediate the onset and development of MMD Conclusions: The results of a thorough bioinformatics investigation of miRNAs and mRNAs in MDD showed that miR3P and miR-206 might be effective biomarkers and possible therapeutic targets for the treatment of MDD via nerve-immunity interaction. +exosome 35467477 hsa-mir-524 Carcinoma, Non-Small-Cell Lung 5p-METTL3/SOX2 axis in A549/DDP and H1299/DDP cells.Exosomal circVMP1 transmits the malignant properties and DDP resistance to DDP-sensitive cells. +circulation_biomarker_diagnosis_up 35467432 hsa-mir-222 Carcinoma, Hepatocellular AIMS: This study was conducted to assess the ability of the serum expression of exosomal miR-18a and miR-222 to differentiate and diagnose patients with HCC, patients with liver cirrhosis, and healthy controls. +other 35467432 hsa-mir-18a Carcinoma, Hepatocellular Moreover, miR-18a and miR-222 could be useful in identifying liver injuries, including fibrosis and cirrhosis. +lncRNA target 35467292 hsa-mir-106a Vascular Calcification CircHIPK3 regulated osteogenic and cartilage differentiation of VSMC via miR-106a-5p/MFN2 axis, indicating a target for treating vascular calcification. +genetics_GWAS 35467177 hsa-mir-145 Urinary Bladder Neoplasms At the end, blood samples and bladder tissues were collected and checked for the presence of malignancy, markers of angiogenesis (VEGF relative gene expression), inflammation (IL-6), proliferation (KI-67 expressions), oxidative stress (serum MDA and serum SOD) and epigenetic control (miRNA-145 level). +genetics_overexpression_promote 35467063 hsa-mir-224 Squamous Cell Carcinoma of Head and Neck Overexpression of MALAT1 and KDM2A or miR +lncRNA target 35467005 hsa-mir-486 Adenocarcinoma of Lung 5p suppressed cell malignant progression in LUAD by targeting SAPCD2, suggesting that the two may be targets for LUAD treatment. +genetics_knock down_suppress 35466471 hsa-mir-103a Carcinoma, Renal Cell In addition, SNHG1 knockdown and miR-103a overexpression significantly inhibited progression of RCC. +lncRNA target 35466323 hsa-mir-196 Cholangiocarcinoma 5p inhibition notably suppressed cell proliferation as well as metastasis in CCA cell line HuCCT1. +lncRNA target 35466322 hsa-mir-135a Osteosarcoma High expression levels of miR-135a promoted transplanted tumor development in vivo and the proliferation and migration of OS cells by targeting SMAD2. +genetics_knock down_suppress 35466320 hsa-mir-145 Colorectal Neoplasms 5p reverted the effects of CBR3-AS1 knockdown on CRC cells. +lncRNA target 35466317 hsa-mir-513 Carcinoma, Hepatocellular qRT-PCR experiments confirmed that olaparib could increase PD-L1 expression through inhibiting miR-513 in HCC cells. CONCLUSION: The present study reveals that inhibition of PARP potentiates immune checkpoint therapy through the miR-513/PD-L1 pathway in HCC and the combination of PARP inhibitor olaparib and anti-PD1 is beneficial to HCC therapy. +genetics_knock down_promote 35466313 hsa-mir-144 Stomach Neoplasms 3p inhibition or EZH2 restoration largely blocked the effects of circKIF4A knockdown on the malignant behaviors of GC cells. +other 35465986 hsa-mir-424 Enzootic Bovine Leukosis 5p in milk sEV could be one of the characteristic trends in cattle that are high risk for BLV transmission. +genetics_overexpression_promote 35465967 hsa-mir-520 Stomach Neoplasms 3p overexpression on the proliferation of GC cells. +genetics_overexpression_suppress 35465835 hsa-mir-23a Uterine Cervical Neoplasms In addition, SLC7A11 rescued the effect of miR-23a-5p overexpression on progression of CC cells. +lncRNA target 35465051 hsa-mir-200 Graft Occlusion, Vascular Our study unraveled the substantial contribution of miRNAs in regulating the SMC transcriptome and identified the miR-200 cluster as a pro-quiescence mechanism and a potential inhibitor of vascular restenosis. +lncRNA target 35465017 hsa-mir-552 Ovarian Neoplasms, High-Grade Serous Collectively, these findings suggest that Linc00261, a mediator of EMT progression, can target oncogenic miR-552, elevating ATG10 expression, to prevent high-grade serous ovarian cancer tumorigenesis and may serve as a potential novel therapeutic target. +other 35464137 hsa-mir-122 Liver Injury MicroRNA-122 (miR-122) has been proposed as a sensitive DILI marker although no commercial applications are available yet. +genetics_overexpression_promote 35464065 hsa-mir-22 Diabetes Mellitus, Type 1 By RNA sequencing, we noticed that Tumor necrosis factor (TNF) signaling was the only pathway that was significantly and oppositely altered in these two experimental sets, with it upregulated in DM1 and inhibited by miR-322/-503 overexpression. +circulation_biomarker_diagnosis_ns 35463986 hsa-mir-34a Coronary Occlusion OBJECTIVE: By detecting the levels of external counterpulsation combined with exercise therapy on the levels of moesin, angiopoietin-like protein2 (Angptl 2), angiopoietin-like protein (Angptl 3), hypoxia inducible factor-1alpha (HIF-1alpha), and RNA-34a (miR-34a) in patients with coronary artery occlusive disease, the effect of external counterpulsation combined with exercise therapy on the establishment of occluded coronary collateral circulation was studied. +transcription factor target 35463769 hsa-mir-3925 Dmd-Associated Dilated Cardiomyopathy Furthermore, the higher OGDHL protein expression, except the change of PLA2G2, was also found in DCM hearts, and its mRNA expression was negatively correlated with myocardial Masson's scores (r = -0.84, P = 0.009) and left ventricular end-diastolic diameter (LVEDd; r = -0.82, P = 0.014), which might be regulated by miR5p through further bioinformatics prediction and qRT-PCR verification. +circulation_biomarker_diagnosis_up 35463692 hsa-mir-103a Parkinson Disease To explore the inhibition of pramipexole on the neuronal apoptosis and its influences on the expressions of brain tissue brain-derived neurotrophic factor (BDNF), and serum miR-103a and miR-30b and inflammatory factors in rats with Parkinson's disease. Pramipexole may up-regulate the expressions of BDNF, miR-103a and miR-30b to inhibit the apoptosis and inflammation in Parkinson's disease model rats. +lncRNA target 35463310 hsa-mir-490 Nasopharyngeal Carcinoma 3p, which may contribute to new prognostic markers and promising therapeutic targets. +other 35463276 hsa-mir-296 Glioma We also identify the lncRNA/miR5p/GSDMD regulatory axis as an important player in glioma progression. +other 35463266 hsa-mir-149 Pulmonary Disease, Chronic Obstructive OBJECTIVE: To study the mechanism of chronic obstructive pulmonary disease (COPD) in diagnosing alveolar factors and analyze the effect of miR3p on alveolar inflammatory factors and the expression of surfactant protein D (SP-D) and SP-A on the lung surface mediated by Wnt pathway. +transcription factor target 35463073 hsa-mir-3912 Osteosarcoma CONCLUSION: Our data clearly indicate that GN is a candidate drug for OS treatment, and GN plays its role through miR3p/ANGPTL4 in OS. +circulation_biomarker_diagnosis_down 35462367 hsa-mir-654 Coronary Artery Disease 5p was significantly downregulated in the plasma of CAD patients and tumor necrosis factor-a/platelet-derived growth factor (PDGF)-BB-stimulated VSMCs. +other 35462331 hsa-mir-9 Leukemia, Myeloid, Acute Furthermore, we report a direct linkage of miR-9 to ABCB1 efflux activity in the PBMC and propose miR-9 as a useful prognostic marker in AML. Moreover, we suggest miR-9 as a predictive ABCB1-related biomarker that could be immensely helpful in identifying ABCB1-resistant AML phenotype to enable optimized therapeutic regimen and improved treatment outcome. +tissue_expression_ns 35462240 hsa-mir-181a Atherosclerosis Endothelial miR-181a2b2 deficiency regulates multiple key pathways related to endothelial inflammation, cell adhesion, cell cycle, and immune response involved in the development of atherosclerosis. +genetics_GWAS 35462240 hsa-mir-181b Atherosclerosis The aim of this study is to examine the role of genetic deficiency of the miR-181b locus in endothelial cells during atherogenesis. +other 35462006 hsa-mir-200c Acquired Immunodeficiency Syndrome 3p, known to be associated with MDD and CI; all were normalized by PDDC. +other 35462006 hsa-mir-200c Depressive Disorder, Major 3p, known to be associated with MDD and CI; all were normalized by PDDC. +other 35462006 hsa-mir-429 Depressive Disorder, Major 3p, known to be associated with MDD and CI; all were normalized by PDDC. +other 35462006 hsa-mir-183 Depressive Disorder, Major 3p, known to be associated with MDD and CI; all were normalized by PDDC. +other 35462006 hsa-mir-183 Acquired Immunodeficiency Syndrome 3p, known to be associated with MDD and CI; all were normalized by PDDC. +other 35462006 hsa-mir-183 Osteoarthropathy, Primary Hypertrophic 3p, known to be associated with MDD and CI; all were normalized by PDDC. +other 35462006 hsa-mir-429 Osteoarthropathy, Primary Hypertrophic 3p, known to be associated with MDD and CI; all were normalized by PDDC. +other 35462006 hsa-mir-200c Osteoarthropathy, Primary Hypertrophic 3p, known to be associated with MDD and CI; all were normalized by PDDC. +other 35462006 hsa-mir-429 Acquired Immunodeficiency Syndrome 3p, known to be associated with MDD and CI; all were normalized by PDDC. +other 35461401 hsa-mir-146a developmental and epileptic encephalopathy 3p can be used as epileptic encephalopathy biomarkers. +other 35461401 hsa-mir-138 developmental and epileptic encephalopathy 3p can be used as epileptic encephalopathy biomarkers. +other 35461401 hsa-mir-187 developmental and epileptic encephalopathy 3p can be used as epileptic encephalopathy biomarkers. +circulation_biomarker_diagnosis_ns 35461393 hsa-mir-380 Diabetic Retinopathy 3p expression increased 2.6-fold in the serum of DR patients. +circulation_biomarker_diagnosis_ns 35461372 hsa-let-7b Carcinoma, Non-Small-Cell Lung These findings suggest that the expression levels of circulating hsa-miR +exosome 35461336 hsa-mir-17 Colorectal Neoplasms Upregulated CRCSC-exosomal miR +lncRNA target 35461324 hsa-mir-601 Osteosarcoma The results of in vitro and in vivo assay revealed that elevated miR-601 inhibited the proliferative, migratory and invasive capacities in OS cells. +transcription factor target 35461040 hsa-mir-377 Carcinoma, Hepatocellular 3p facilitates the proliferation and suppresses the cell cycle arrest and apoptosis in HCC by affecting transcription factor EGR1-mediated p53 activation. +other 35461010 hsa-mir-200a Autoimmune Diseases Previous research has demonstrated that microRNA-200a regulates cell apoptosis, tumor progression, and autoimmune disease. +genetics_overexpression_promote 35460876 hsa-mir-1263 Arthritis, Rheumatoid Functionally, overexpression of miR-1263 suppressed the development of HFLS-RA by blocking the NF-kappaB pathway, and this phenomenon was reversed by the upregulation of REL. +exosome 35460835 hsa-mir-124 Breast Neoplasms 3p, the local miRNA sponged by the exosomal circHIPK3.circHIPK3 enclosed in the BC cell-derived exosomes enhanced MTDH expression in the endothelial cell by sponging miR +other 35460694 hsa-mir-200c Fatty Liver, Alcoholic Taken together, these results suggest that miR-200c contributes to the modulation of lipid homeostasis in AFL disease by cooperatively regulating Hnf1b and ApoO functions. +genetics_knock down_promote 35460538 hsa-mir-515 Nasopharyngeal Carcinoma CONCLUSION: Circ_0004788 knockdown restrained the progression of NPC via the miR +lncRNA target 35460500 hsa-mir-128 Glioma CONCLUSION: The overall results indicated that LINC02381 exerts its oncogenic effect in glioma cells through sponging miR-128 and miR-150 to upregulate the IGF1R signaling pathway. Our results introduce LINC02381 and miR-128, and miR-150 as potential prognosis and therapy targets for the treatment of glioma. +lncRNA target 35460500 hsa-mir-150 Glioma CONCLUSION: The overall results indicated that LINC02381 exerts its oncogenic effect in glioma cells through sponging miR-128 and miR-150 to upregulate the IGF1R signaling pathway. Our results introduce LINC02381 and miR-128, and miR-150 as potential prognosis and therapy targets for the treatment of glioma. +exosome 35460420 hsa-mir-431 Colorectal Neoplasms 5p serves as a prognostic biomarker in CRC, and hUCMSC-Exos transfer of miR +genetics_overexpression_promote 35460386 hsa-mir-1323 Carcinoma, Non-Small-Cell Lung Circ_0030998 overexpression-mediated effects on the DDP resistance and malignant properties of NSCLC cells were largely based on its negative regulation of miR-1323. +lncRNA target 35460325 hsa-mir-708 Ventricular Premature Complexes 5p has a crucial effect on VC via targeting Pit-1 and inhibiting Wnt8b/beta-catenin pathway, it may serve as a new target for VC treatment. +other 35460089 hsa-mir-223 Ataxia Telangiectasia The present results discovered that a combination of AT DE intervention improves the miR-33 and miR-223 in the liver of obese rats. +circulation_biomarker_diagnosis_ns 35460089 hsa-mir-3 Obesity These findings show that long-term AT combined with the intake of DE may improve the plasma levels of Apo B, and TC and HDL-C levels in the liver, which is probably due to AT and DE positive effects on miR-33 and miR-223 in the liver of obese rats. +circulation_biomarker_diagnosis_ns 35460089 hsa-mir-223 Obesity These findings show that long-term AT combined with the intake of DE may improve the plasma levels of Apo B, and TC and HDL-C levels in the liver, which is probably due to AT and DE positive effects on miR-33 and miR-223 in the liver of obese rats. +other 35460089 hsa-mir-3 Ataxia Telangiectasia The liver expression of miR-33 was lower in the AT, DE, AT DE, and NC groups compared with the OC group. The present results discovered that a combination of AT DE intervention improves the miR-33 and miR-223 in the liver of obese rats. +lncRNA target 35459765 hsa-mir-27b Fetal Macrosomia MiR-27b was probably involved in non-GDM macrosomia through negative regulation of PPARalpha/gamma protein. +lncRNA target 35459441 hsa-mir-513a Adenocarcinoma of Lung miR-513a-3p has been found to sensitize human lung adenocarcinoma cells to chemotherapy by targeting glutathione S-transferase P1 (GSTP1). +exosome 35459211 hsa-mir-124 Reperfusion Injury miR3p in HM-exos downregulates Steap3 expression to inhibit ferroptosis, thereby attenuating graft IRI, which might be a promising strategy to treat IRI in steatotic grafts. +transcription factor target 35459188 hsa-mir-4701 Arthritis, Rheumatoid 5p is evidenced to be participated in synovial invasion and joint destruction. +transcription factor target 35459188 hsa-mir-4701 Osteoarthritis 5p could alleviate the inflammatory injury of IL-1beta-treated CHON-001 cells via down-regulating HMGA1, indicating that miRNA +circRNA target 35459186 hsa-mir-615 Carcinoma, Pancreatic Ductal CONCLUSION: Circ-MTHFD1L maintains PDAC gemcitabine resistance through the miR3p/RPN6 signal axis. +other 35458670 hsa-mir-16 Diabetes Mellitus, Type 2 Higher expression levels of miR-134 were prognostic for MACCE in diabetic patients, while higher expression levels of miR-16 were prognostic in non-diabetic patients. +other 35458670 hsa-mir-16 Diabetes Mellitus Higher expression levels of miR-134 were prognostic for MACCE in diabetic patients, while higher expression levels of miR-16 were prognostic in non-diabetic patients. +other 35458670 hsa-mir-208b Diabetes Mellitus 5p (1.0006; 1.00011.0012, p = 0.016), miR-208b-3p (2.82; 0.918.71, p = 0.071), and hypertension (0.27, 0.080.95, p = 0.042) were associated with MACCE. +other 35458670 hsa-mir-134 Diabetes Mellitus, Type 2 Higher expression levels of miR-134 were prognostic for MACCE in diabetic patients, while higher expression levels of miR-16 were prognostic in non-diabetic patients. +other 35458670 hsa-mir-134 Diabetes Mellitus Higher expression levels of miR-134 were prognostic for MACCE in diabetic patients, while higher expression levels of miR-16 were prognostic in non-diabetic patients. +other 35458670 hsa-mir-208b Diabetes Mellitus, Type 2 5p (1.0006; 1.00011.0012, p = 0.016), miR-208b-3p (2.82; 0.918.71, p = 0.071), and hypertension (0.27, 0.080.95, p = 0.042) were associated with MACCE. +other 35458112 hsa-mir-451 Obesity These results may provide insights into the functions of miR-451 and food-derived phytoestrogens in ameliorating and preventing gluconeogenesis-related diseases. +transcription factor target 35457185 hsa-mir-200b Esophageal Squamous Cell Carcinoma Conversely, the suppression of miR-200b and miR-200c in ESCC cells attenuated E-cadherin, and that converted cells to mesenchymal type by elevating N-cadherin expression, and impaired cell sensitivity to CCRT treatment. Conclusively, miR-200b and miR-200c can modulate the conversion of epithelial-mesenchymal phenotype in ESCC, and thereby altering the response of cells to CCRT treatment. +transcription factor target 35457185 hsa-mir-200c Esophageal Squamous Cell Carcinoma Conversely, the suppression of miR-200b and miR-200c in ESCC cells attenuated E-cadherin, and that converted cells to mesenchymal type by elevating N-cadherin expression, and impaired cell sensitivity to CCRT treatment. Conclusively, miR-200b and miR-200c can modulate the conversion of epithelial-mesenchymal phenotype in ESCC, and thereby altering the response of cells to CCRT treatment. +circulation_biomarker_diagnosis_ns 35457094 hsa-mir-222 Diabetes, Gestational 3p are two circulating biomarkers that could improve GDM classification power and act in the context of the molecular events leading to the metabolic alterations observed in GDM. +circulation_biomarker_diagnosis_ns 35457094 hsa-mir-409 Diabetes, Gestational 3p are two circulating biomarkers that could improve GDM classification power and act in the context of the molecular events leading to the metabolic alterations observed in GDM. +transcription factor target 35457012 hsa-mir-614 Prostatic Neoplasms 5p exerts a significant inhibitory effect on cell viability and colony formation and induces sub-G1 cell cycle arrest and apoptosis in human prostate cancer cells. +other 35456995 hsa-mir-133a Heart Diseases Despite additional unexplored factors being possible contributors to this negative feedback mechanism, miR-133a might also be considered as a potential therapeutic tool for the diagnosis, therapy and prognosis of cardiac diseases. +lncRNA target 35456497 hsa-mir-200 Breast Neoplasms Breast cancer cells with mesenchymal characteristics, particularly the claudin-low subtype, express extremely low levels of miR-200s. This is the first study to implicate MXRA8 in human breast cancer, and our data suggests that miR-200s inhibit growth and metastasis of claudin-low mammary tumor cells in vivo through downregulating MXRA8 expression. +genetics_GWAS 35456485 hsa-mir-129 Heart Failure 5p overexpression was found to significantly inhibit the expression of hair follicle development-related genes (HFDRGs), such as BCL2, WNT2, CCND1, and LEF1 (p < 0.01), and promoted the expression of SFRP2, TGF-1, and FGF2 (p < 0.01), which was the same as the knockdown of HOXC13. +genetics_GWAS 35456485 hsa-mir-129 Hair Diseases These results will help to understand the role and mechanism of miR5p in the periodic development of HF, and will provide support for subsequent studies, not only providing a theoretical basis for genetically improving the quality of hair in animals in the future, but also a new theory and method for diagnosing and treating hair loss in humans. +transcription factor target 35456471 hsa-mir-132 Telangiectasia, Hereditary Hemorrhagic 3p, in HHT MACs was identified. +transcription factor target 35456441 hsa-mir-24 Endomyocardial Fibrosis In brief, we revealed that miR3p promoted proliferation but inhibited differentiation of intramuscular preadipocytes by blocking ANXA6 expression, thus dominating IMF deposition in broilers. +other 35456428 hsa-mir-27a Prostatic Neoplasms Conversely, in the CaP cases, higher levels of miR 27a-3p and AR were observed. +other 35456428 hsa-mir-124 Prostatic Neoplasms RESULTS: Levels of miRs 124, 130a, 488-3p, and 506 were higher in NPH samples. +other 35456428 hsa-mir-488 Prostatic Neoplasms RESULTS: Levels of miRs 124, 130a, 488-3p, and 506 were higher in NPH samples. +other 35456428 hsa-mir-130a Prostatic Neoplasms RESULTS: Levels of miRs 124, 130a, 488-3p, and 506 were higher in NPH samples. +other 35456388 hsa-mir-671 Exfoliation Syndrome 5p expression in PEX are needed. +other 35456388 hsa-mir-1307 Exfoliation Syndrome 5p expression in PEX are needed. +other 35456388 hsa-mir-374a Exfoliation Syndrome 5p expression in PEX are needed. +other 35456388 hsa-mir-708 Exfoliation Syndrome 5p expression in PEX are needed. +other 35455956 hsa-mir-182 Fibromyalgia qRT-PCR validated miR5p upregulation, distinguishing FMS patients from healthy controls. +other 35455702 hsa-mir-196a-2 Polycystic Ovary Syndrome The distribution of Kruppel-like factor 14 rs972283 G > A, miR-27a rs895819 A > G, and miR-196a-2 rs11614913 C > T genotypes analyzed within PCOS patients and healthy controls in the considered population was significant (p < 0.05), except for miR-423 rs6505162 C > A genotypes (p > 0.05). Moreover, allele A of KLF-14 and allele T of miR-196a2 were strongly associated with PCOS susceptibility in the considered population. +other 35455702 hsa-mir-196a Polycystic Ovary Syndrome The distribution of Kruppel-like factor 14 rs972283 G > A, miR-27a rs895819 A > G, and miR-196a-2 rs11614913 C > T genotypes analyzed within PCOS patients and healthy controls in the considered population was significant (p < 0.05), except for miR-423 rs6505162 C > A genotypes (p > 0.05). Moreover, allele A of KLF-14 and allele T of miR-196a2 were strongly associated with PCOS susceptibility in the considered population. +circulation_biomarker_diagnosis_up 35455065 hsa-mir-212 COVID-19 This study aims to investigate the serum level of sACE2 and 4 miRNAs (miR-421, miR-3909, miR +other 35455042 hsa-mir-138 Atherosclerosis Altogether, this study demonstrated that the miRAPT1 axis may be partially responsible for atherosclerosis development by regulating the H-Ras-MAPK signaling pathway and hBP transportation. +circulation_biomarker_diagnosis_up 35454929 hsa-let-7i Hepatitis C After Cox's regression model was used to adjust for age, sex, HCV genotype, and FIB-4 >/= 3.25, patients with CHC with let-7i median >/= -1.696 (adjusted hazard ratio [aHR] = 0.31, 95% CI: 0.08-0.94, p = 0.0372) in the sustained virologic response (SVR) groups and >/=-1.696 (aHR = 0.09, 95% CI: 0.08-0.94, p = 0.0022) in the non-SVR group were less likely to develop HCC. Thus, circulating let-7i can be used for early CHC surveillance in patients with HCC risk after antiviral treatment. +circulation_biomarker_diagnosis_up 35454929 hsa-let-7i Carcinoma, Hepatocellular After Cox's regression model was used to adjust for age, sex, HCV genotype, and FIB-4 >/= 3.25, patients with CHC with let-7i median >/= -1.696 (adjusted hazard ratio [aHR] = 0.31, 95% CI: 0.08-0.94, p = 0.0372) in the sustained virologic response (SVR) groups and >/=-1.696 (aHR = 0.09, 95% CI: 0.08-0.94, p = 0.0022) in the non-SVR group were less likely to develop HCC. Thus, circulating let-7i can be used for early CHC surveillance in patients with HCC risk after antiviral treatment. +target gene 35454815 hsa-mir-34a Neuroblastoma Cannabinol Inhibits Cellular Proliferation, Invasion, and Angiogenesis of Neuroblastoma via Novel miR-34a/tRiMetF31/PFKFB3 Axis. +genetics_overexpression_promote 35454146 hsa-mir-107 Diabetes Mellitus, Type 2 Finally, the overexpression of miR-107 was associated with higher HOMA-IR in the diabetic group (r = 0.373, p = 0.035). +circulation_biomarker_diagnosis_up 35453838 hsa-mir-34a Breast Neoplasms Conclusions: Circulating serum miR-155, miR-373, miR-10b, and miR-34a are potential biomarkers for early BC detection in Egyptian patients and their combination shows high sensitivity and specificity. +lncRNA target 35453669 hsa-mir-195 Inflammatory Bowel Diseases Our data support a previously unreported role of miR5p in intestinal tight junctions' regulation and suggest a potential pharmacological target for new therapeutic approaches in IBD. +lncRNA target 35453643 hsa-mir-92b ankylosing spondylitis 1 In PsA, a unique regulatory pathway exists through miR-26a +lncRNA target 35453643 hsa-mir-223 ankylosing spondylitis 1 In PsA, a unique regulatory pathway exists through miR-26a +lncRNA target 35453643 hsa-mir-92b Arthritis, Psoriatic In PsA, a unique regulatory pathway exists through miR-26a +lncRNA target 35453643 hsa-mir-223 Arthritis, Psoriatic In PsA, a unique regulatory pathway exists through miR-26a +lncRNA target 35453643 hsa-mir-223 Arthritis, Rheumatoid In PsA, a unique regulatory pathway exists through miR-26a +other 35453643 hsa-mir-10b ankylosing spondylitis 1 3p in AS, and let-7d-5p in RA. +other 35453643 hsa-mir-10b Arthritis, Psoriatic 3p in AS, and let-7d-5p in RA. +other 35453643 hsa-mir-10b Arthritis, Rheumatoid 3p in AS, and let-7d-5p in RA. +lncRNA target 35453643 hsa-mir-92b Arthritis, Rheumatoid In PsA, a unique regulatory pathway exists through miR-26a +other 35453608 hsa-mir-371a COVID-19 The upregulation of the miR-371a-3p is responsible for the downregulation of the AR in SARS-CoVpositive patients, resulting in decreased spermatogenesis. +lncRNA target 35453537 hsa-mir-665 Optic Atrophy, Hereditary, Leber Predicted by bioinformatics approaches, hsa_circ_0087207 acts as the sponge of miR-665 to induce the expression of a variety of apoptosis-related genes in LHON patient iPSC-derived RGCs. Targeting the hsa_circ_0087207/miR-665 axis might hold therapeutic promises for the treatment of LHON. +other 35452958 hsa-mir-147 Myocardial Infarction A recent report indicates that miR-147 expression is decreased in the myocardium of a myocardial infarction model, suggesting a potential role of this miRNA in DOX-induced cardiomyocyte toxicity. +genetics_overexpression_promote 35452863 hsa-mir-142 Porcine Reproductive and Respiratory Syndrome Subsequently, we showed that overexpression of miR +circRNA target 35452749 hsa-mir-124 Reperfusion Injury, Cerebral Ischemia This is the first time that circRNAs have been shown to be closely related to brain IR injury and RIPostC and suggests that targeting the circRNA_0002286-miR3p-VLCAD pathway might attenuate brain IR injury. +circulation_biomarker_diagnosis_ns 35452574 hsa-mir-218 Obesity 5p levels are significantly (p<0.05) increased in accordance with serum leptin levels in obese children. +lncRNA target 35452510 hsa-mir-34a Necrobiotic Disorders MiR-34a (a Bcl-2 inhibitor), G-CSF (a miR-34a inhibitor), MAPK activation (pro-cell death), and citrulline (a biomarker of entroepithelial proliferation), active caspase-3 (a biomarker of apoptosis) and caspase-1 activated gasdermin D (a pyroptosis biomarker) were measured in the sternum, femur BM and ileum. +lncRNA target 35452205 hsa-mir-15b Adenocarcinoma of Lung In conclusion, LINC00342 promotes metastasis of lung adenocarcinoma through inducing TPBG targeted by miR-15b. +lncRNA target 35452205 hsa-mir-15 Adenocarcinoma of Lung In conclusion, LINC00342 promotes metastasis of lung adenocarcinoma through inducing TPBG targeted by miR-15b. +exosome 35452193 hsa-mir-503 Myocardial Infarction, Acute EV-encapsulated miR-503, which is enriched during the early phase of AMI, is a critical molecule that mediates myocardial injury. +circulation_biomarker_diagnosis_down 35451884 hsa-mir-21 Endometriosis Cytoplasmic polyadenylation element-binding protein 3 (CPEB3), a potential target of miR5p, is downregulated in endometriotic specimens. +circulation_biomarker_diagnosis_up 35451808 hsa-mir-214 Cognition Disorders RESULTS: We identified 76 differentially expressed plasma exosomal miRNAs in PND patients after surgery (P<0.05, mid R:log2FCmid R:>0.58), including the upregulated hsa-miR +genetics_overexpression_promote 35451652 hsa-mir-584 Lung Neoplasms 3p could reverse the repressive effects of reduced LINC00174 on the development of LC cells; while RPS24 overexpression inverted the repressive effects of miR +lncRNA target 35451651 hsa-mir-222 Ovarian Neoplasms 3p inhibited the migration and proliferation of OC cells. +lncRNA target 35451584 hsa-mir-1 Carcinoma, Non-Small-Cell Lung CONCLUSION: LINC00174, as a competitive endogenous RNA, elevates LATS2 expression by adsorbing miR5p, thereby inhibiting the viability and migration of NSCLC cells, and promoting apoptosis. +target gene 35451580 hsa-mir-205 Liver Neoplasms miR-205 Reverses MDR-1 Mediated Doxorubicin Resistance via PTEN in Human Liver Cancer HepG2 Cells. +lncRNA target 35451558 hsa-mir-450a Breast Neoplasms We revealed that miR-450a mimic transfected breast cancer cells (T47D and BT474) exhibited attenuated capacities of proliferation, migration, and invasion in vitro, and miR-450a suppressed T47D cell growth in a xenograft tumor model. +lncRNA target 35451420 hsa-mir-10b Ischemic Stroke Thus, lncRNA NEAT1 inhibited inflammasome activation by NLRP3 in microglia via the NEAT1/ miR10b5p/BCL6/NLRP3 regulatory axis, which alleviated deleterious outcomes of ischemic stroke. +other 35450554 hsa-mir-212 Diabetes Mellitus, Type 2 Several microRNAs, including miR3p, miR-30e-3p and miR-638, stratified glucose-intolerant women from NGT at childhood. +other 35449863 hsa-mir-129 Encephalomyelitis, Autoimmune, Experimental As a result, we may assume the autoimmune disease illness has progressed once concentrations of HMGB1, TLR4/NF-kappaB, and miR5p have decreased. +transcription factor target 35449817 hsa-mir-584 Inflammation TargetScan software analysis showed that miR5p can bind to the 3' noncoding region of TLR4, which is involved in the occurrence and development of ALI, thereby affecting the inflammatory pathway and inflammation development. +transcription factor target 35449817 hsa-mir-584 Acute Lung Injury TargetScan software analysis showed that miR +other 35449729 hsa-mir-181a Precursor Cell Lymphoblastic Leukemia-Lymphoma After validating in international cohorts, the joint quantification of miR-181a and VEGF-A might provide a novel tool to precisely diagnose CNS involvement and adjust CNS-directed therapy in pALL. +genetics_overexpression_promote 35449370 hsa-mir-561 Fibrosis, Renal Knocking down circACTR2 and overexpressing miR-561 may, thus, benefit the treatment of renal fibrosis. +genetics_knock down_promote 35449340 hsa-mir-106a Ovarian Neoplasms OC cells were treated with SKOV3-EVs or SKOV3-EVs overexpressing miR-106a-5p to detect the proliferation, migration, and invasion. +circRNA target 35449053 hsa-mir-6795 Diabetes, Gestational CONCLUSION: circMAP3K4 could suppress the insulin-PI3K/Akt signaling pathway via miR +other 35448502 hsa-mir-277 Colorectal Neoplasms We also investigated miR-277 effects on ISC in a benign and our newly developed CRISPR-Cas9-based colorectal cancer model and found effects on ISC survival, which as a consequence affects tumor growth, further underlining the importance of FAO in a pathological context. +other 35447890 hsa-mir-532 Pulmonary Disease, Chronic Obstructive 5p and miR-451b) replicated. +other 35447890 hsa-mir-296 Asthma 5p and miR-451b) replicated. +other 35447890 hsa-mir-451b Asthma 5p and miR-451b) replicated. +other 35447890 hsa-mir-7 Pulmonary Disease, Chronic Obstructive 5p and miR-451b) replicated. +other 35447890 hsa-mir-296 Pulmonary Disease, Chronic Obstructive 5p and miR-451b) replicated. +other 35447890 hsa-mir-7 Asthma 5p and miR-451b) replicated. +other 35447890 hsa-mir-451b Pulmonary Disease, Chronic Obstructive 5p and miR-451b) replicated. +other 35447890 hsa-mir-532 Asthma 5p and miR-451b) replicated. +lncRNA target 35447001 hsa-mir-127 Thyroid Neoplasms Mechanistically, hsa_circ_0000285 induced the development of THCA via functioning as a competing endogenous RNA (ceRNA) of miR +other 35446623 hsa-mir-29a Virus Diseases Here, we interrogated the role of microRNAs (miRs) in CD8 T cells responding to acutely resolved or chronic viral infection and identified miR-29a as a key regulator of TEX. Enforced expression of miR-29a improved CD8 T cell responses during chronic viral infection and antagonized exhaustion. +lncRNA target 35446199 hsa-mir-760 Carcinoma, Renal Cell Additionally, we found that linc01133 promotes RCC cell proliferation, migration and invasion through sponging miR-760. +circulation_biomarker_diagnosis_ns 35446157 hsa-mir-200b Arteriovenous Fistula CONCLUSION: Our study indicates that serum exosome-derived miR-200b-3p regulate VEGF and Ang-II to increase intimal hyperplasia to induce AVF thrombosis. +other 35446157 hsa-mir-200 Arteriovenous Fistula Besides miR-200b-3p, miR-200 family may also play a regulatory role in AVF thrombosis. +other 35446157 hsa-mir-429 Arteriovenous Fistula RESULTS: There are 43 miRNA down-regulation and 15 miRNA up-regulation between MHD group and MHD+Thrombus group, the expression levels of miR-200b-3p and miR-429 in MHD with thrombus were significantly increased (p < 0.001, p < 0.05). +circulation_biomarker_diagnosis_ns 35445913 hsa-mir-203 Urinary Bladder Neoplasms miR-203 expression was considerably higher in serum of UBC patients but non-significant as compared to BPH controls. +other 35445913 hsa-mir-34a Urinary Bladder Neoplasms This study aimed to identify a CD44-linked microRNAs (miRNAs) (miR-9, miR-34a, miR-203) for non-invasive diagnosis of bladder cancer from other urinary tract malignancies. +other 35445913 hsa-mir-9 Urinary Bladder Neoplasms This study aimed to identify a CD44-linked microRNAs (miRNAs) (miR-9, miR-34a, miR-203) for non-invasive diagnosis of bladder cancer from other urinary tract malignancies. +genetics_overexpression_promote 35445786 hsa-mir-7 Carcinoma, Non-Small-Cell Lung 5p inhibitor on NSCLC cell malignancy, while PFN2 overexpression reversed the inhibitory impact of miR +lncRNA target 35445231 hsa-mir-223 Osteosarcoma A series of in vitro anti-tumor assays illustrate that the PGEA-2 vector can efficiently deliver miR-223 into osteosarcoma cells for impressive anti-tumor effects via inhibiting malignant behavior of osteosarcoma cells, including proliferation, migration, and invasion. +circulation_biomarker_diagnosis_ns 35445179 hsa-mir-490 Breast Neoplasms 3p in peripheral blood mononuclear cells (PBMCs) and plasma of patients with BC. +other 35445044 hsa-mir-145 Retinopathy of Prematurity Intravitreal injection of miR5p mimics reduced the degree of retinopathy. +transcription factor target 35445025 hsa-mir-513c Venous Thrombosis Collectively, these results revealed that the pyroptosis of VECs induced by decreased miR-513c-5p was involved in DVT progression and indicated a potential therapeutic strategy of targeting the miR-513c-5p/caspase-1/GSDMD signal axis for DVT management. +lncRNA target 35444864 hsa-mir-34a Herpesviridae Infections CONCLUSION: Upregulated miR-34a-5p in KSHV-infected SH-SY5Y cells suppressed cell proliferation and migration through down-regulating c-fos. +lncRNA target 35444785 hsa-mir-520a Carcinoma, Non-Small-Cell Lung More importantly, the suppression of SBF2-AS1 silencing on the proliferation, migration, and invasion in NSCLC cells was counteracted by miR-520a-3p inhibition. +circulation_biomarker_prognosis_ns 35444778 hsa-mir-184 Carcinoma, Non-Small-Cell Lung The expression level of miR-184 in serum exosomes of NSCLC patients is significantly increased, which has a certain value for the differential diagnosis of the nature of benign and malignant lung diseases and is closely related to the prognosis of patients. +other 35444696 hsa-mir-29 Stomach Neoplasms RESULTS: The expression levels of miR-29 and miR-101 were significantly lower (p value < 0.0001), but the miR-103 and LPA2 were significantly higher in gastric tumor samples compared to the corresponding nontumor tissues (p value < 0.0001). +other 35444696 hsa-mir-29a Stomach Neoplasms RESULTS: The expression levels of miR-29 and miR-101 were significantly lower (p value < 0.0001), but the miR-103 and LPA2 were significantly higher in gastric tumor samples compared to the corresponding nontumor tissues (p value < 0.0001). +other 35444696 hsa-mir-101 Stomach Neoplasms CONCLUSION: It seems that determining the expression level of miR-101, -103, and -29, as the novel diagnostic biomarkers, has diagnostic value to distinguish GC patients from healthy individuals. +other 35444696 hsa-mir-103 Stomach Neoplasms RESULTS: The expression levels of miR-29 and miR-101 were significantly lower (p value < 0.0001), but the miR-103 and LPA2 were significantly higher in gastric tumor samples compared to the corresponding nontumor tissues (p value < 0.0001). +genetics_knock down_promote 35444695 hsa-mir-520a Carcinoma, Hepatocellular Overexpression of miR-520a-3p and E2F7 knockdown reversed the role of circLATS2 in promoting malignant behavior of HCC cells and affected phosphorylation of VEGFR2. +circulation_biomarker_diagnosis_ns 35444657 hsa-mir-146a Lupus Erythematosus, Systemic However, miR146a was significantly decreased in SLE patients compared to healthy controls and was negatively correlated with plasma estradiol levels and with SLE disease activity scores (SLEDAI). In addition, we found that levels of miR21, miR25, and miR186 positively correlated with SLEDAI and miR146a was negatively correlated in SLE patients. +exosome 35444548 hsa-mir-20a Uterine Cervical Neoplasms Engineered Exosomes-Mediated Transfer of hsa-miR-320a Overcomes Chemoresistance in Cervical Cancer Cells via Targeting MCL1. +transcription factor target 35444435 hsa-mir-138 Diabetic Foot CONCLUSION: Down-regulation of miR-138 could alleviate inflammatory response and promote wound healing in DFU rats by activating PI3K/AKT pathway and hTERT. +other 35444105 hsa-mir-15a Stomach Neoplasms In GC tissues, the expression of SNCG was negatively correlated with that of miR-15a-5p, but was positively correlated with that of SLC25A21-AS1. +lncRNA target 35443866 hsa-mir-4733 Gallbladder Neoplasms 5p was upregulated in GBC and promoted GBC cell proliferation via directly binding to 3' untranslated region (UTR) of KLF, which was downregulated and prohibited the proliferation and migration of GBC cells. +genetics_knock down_suppress 35443864 hsa-mir-124 Fibrosis, Renal In conclusion, KCNQ1OT1 knockdown plays an anti-fibrotic effect through promotion of miR3p expression in renal fibrosis, which provides a promising therapeutic target for the treatment of renal fibrosis. +lncRNA target 35443748 hsa-mir-125a Squamous Cell Carcinoma of Head and Neck Collectively, our study addresses that MIR600HG downregulation elevates miR-125a-5p and reduces RNF44 expression, thereby improving DDP sensitivity and inhibiting glycolysis in DDP-resistant OSCC cells. +lncRNA target 35443748 hsa-mir-600 Squamous Cell Carcinoma of Head and Neck Collectively, our study addresses that MIR600HG downregulation elevates miR-125a-5p and reduces RNF44 expression, thereby improving DDP sensitivity and inhibiting glycolysis in DDP-resistant OSCC cells. +genetics_overexpression_promote 35443745 hsa-mir-146a Colorectal Neoplasms 5p in CXCR7-overexpressing CRC cells and their exosomes. +genetics_overexpression_promote 35443745 hsa-mir-155 Colorectal Neoplasms 5p in CXCR7-overexpressing CRC cells and their exosomes. +genetics_overexpression_promote 35443670 hsa-mir-1 Thyroid Neoplasms RESULTS: MIR31HG was overexpressed in human thyroid cancer, and its overexpression predicted poor prognosis. +circulation_biomarker_diagnosis_ns 35443588 hsa-mir-335 Diabetic Retinopathy CONCLUSIONS: We concluded that plasma miR +other 35443023 hsa-mir-365 Bronchiolitis Obliterans Syndrome 3p, we developed a miRNA signature that, by bioinformatic approaches and linear regression model, utterly improved our potential diagnostic biomarker model for cGVHD. +other 35443023 hsa-mir-148 Bronchiolitis Obliterans Syndrome 3p, we developed a miRNA signature that, by bioinformatic approaches and linear regression model, utterly improved our potential diagnostic biomarker model for cGVHD. +other 35443023 hsa-mir-378 Bronchiolitis Obliterans Syndrome 3p, we developed a miRNA signature that, by bioinformatic approaches and linear regression model, utterly improved our potential diagnostic biomarker model for cGVHD. +other 35442818 hsa-mir-130a Alzheimer Disease CONCLUSION: HOTAIR participated in the regulation of exercises on AD by sponging miR-130a-3p. +other 35442769 hsa-mir-888 Carcinoma, Ductal, Breast Conclusions: Our study indicated that elevated eXpression of miR-888 may be a negative prognostic factor in breast cancer. +genetics_overexpression_promote 35442509 hsa-mir-298 Osteosarcoma Overexpression of JMJD6 reversed the effect of overexpressed miR-298 on alleviating the malignant progression of osteosarcoma. +other 35442501 hsa-mir-1275 Carcinoma, Non-Small-Cell Lung MiR-1275 promotes non-small cell lung cancer cell proliferation and metastasis by regulating LZTS3 expression. +transcription factor target 35442485 hsa-mir-543 Acute Kidney Injury The downregulation of miR-543 remarkably inhibited the inflammation and apoptosis, which was manifested by the reduction of inflammatory cytokines (TNF-, IL-6, IL-1), the reversal of apoptosis-related proteins expression (Bcl-1, Bax), the increase of cell viability and the decrease of the proportion of apoptotic cells. +transcription factor target 35442485 hsa-mir-543 Sepsis The downregulation of miR-543 remarkably inhibited the inflammation and apoptosis, which was manifested by the reduction of inflammatory cytokines (TNF-, IL-6, IL-1), the reversal of apoptosis-related proteins expression (Bcl-1, Bax), the increase of cell viability and the decrease of the proportion of apoptotic cells. +transcription factor target 35442159 hsa-mir-183 Skin Pigmentation Thus, miR5p is an important regulator of melanocytes homeostasis and may be a novel target for autoimmune depigmentation therapy. +circulation_biomarker_prognosis_up 35442113 hsa-mir-200b Multiple Organ Failure Moreover, serum HMGB1 level was increased in MODS patients, and was negatively correlated with miR-200b-3p level. +lncRNA target 35441953 hsa-mir-761 Colorectal Neoplasms LOXL1-AS1 contributed to CRC progression via modulating miR +lncRNA target 35441953 hsa-mir-1224 Colorectal Neoplasms LOXL1-AS1 contributed to CRC progression via modulating miR +lncRNA target 35441676 hsa-mir-21 Lung Neoplasms CONCLUSION: MiRNA-21 has potential clinical value in the diagnosis and prognosis of lung cancer and may serve as an effective diagnostic marker and therapeutic target in the future. +lncRNA target 35441583 hsa-mir-124 Polycystic Ovary Syndrome These findings suggested that LINC00173 could be a latent regulating factor for PCOS progression via modulating the miR +lncRNA target 35441579 hsa-mir-1299 Carcinoma, Non-Small-Cell Lung Through the luciferase activity assay to explore the relationship between MELTF-AS1 and miR-1299, to further understand the effect of silencing MELTF-AS1 on NSCLC. In addition, through luciferase activity analysis and bioinformatics analysis, MELTF-AS1 has a negative effect on miR-1299, and silencing MELTF-AS1 enhanced miR-1299 expression in NSCLC cells. +other 35441575 hsa-mir-192 Diabetic Retinopathy Although microRNA-192 (miR-192) has been demonstrated to be involved in diabetic retinopathy progression, to the best of our knowledge, its potential and mechanism in cell pyroptosis in diabetic retinopathy have not been studied. +genetics_overexpression_promote 35441565 hsa-mir-218 Adenocarcinoma of Lung ERO1A overexpression reversed the suppressive impacts of miR +circRNA target 35441564 hsa-mir-145 Small Cell Lung Carcinoma Our data indicated that circMYC upregulates the expression of MMP-2 by inhibiting miR-145, which functions to promote the proliferation, migration, and invasion and inhibit the apoptosis of SCLC. These findings suggest that targeting circMYC/miR-145/MMP-2 could serve as a potential therapeutic strategy for SCLC treatment. +exosome 35441482 hsa-mir-138 Urinary Bladder Neoplasms 5p is a promising therapeutic agent for BC treatment. +genetics_overexpression_promote 35441352 hsa-mir-125b Osteoarthritis Inhibiting miR-23a/b-3p or overexpressing Grem1 activated transforming growth factor-beta/solvated metal atom dispersed 3 (TGF-beta/Smad) signaling to prevent OA development. +genetics_overexpression_promote 35441352 hsa-mir-23a Osteoarthritis Inhibiting miR-23a/b-3p or overexpressing Grem1 activated transforming growth factor-beta/solvated metal atom dispersed 3 (TGF-beta/Smad) signaling to prevent OA development. +transcription factor target 35440867 hsa-mir-146a Endothelial Dysfunction DISCUSSION: Effects of RUS on sepsis-induced impairments in endothelium relied on the suppression of miR-146a-5p. +circRNA target 35440759 hsa-mir-20a Acute Lung Injury Our findings suggested that circHECTD1 inhibits the apoptosis of AECs through miR-320a/PIK3CA and miR-136/Sirt1 pathways in LPS-induced ALI. +circRNA target 35440759 hsa-mir-136 Acute Lung Injury Our findings suggested that circHECTD1 inhibits the apoptosis of AECs through miR-320a/PIK3CA and miR-136/Sirt1 pathways in LPS-induced ALI. +circRNA target 35440286 hsa-mir-134 Esophageal Squamous Cell Carcinoma Together, our study indicates that the oncogenic role of Circ_0023984 is mediated by miR5p/CST4 Axis in ESCC, which could serve as potential targets for future therapeutic strategies. +lncRNA target 35440106 hsa-mir-532 Stomach Neoplasms MiR-532 was decreased and negatively correlated with E2F1 in GC tissues. This study demonstrates the significant roles of the E2F1-miR-532 double-negative feedback loop in GC progression and may represent a potential target for GC therapy. +genetics_overexpression_promote 35439853 hsa-mir-503 Precursor Cell Lymphoblastic Leukemia-Lymphoma induced increased sensitivity of ALL-resistant cells and CCRF/ CEM-R to dexamethasone was attenuated by overexpression of WNT3A. +other 35439827 hsa-mir-21 Spinal Cord Injuries We aimed to elucidate the regulatory role of miR-21 and test methylprednisolone as a disease-modifying agent on experimental SCI tissues. CONCLUSIONS: miR-21 supports the beneficial aspects of the body's healing mechanisms following SCI. +lncRNA target 35439733 hsa-mir-27b Osteoarthritis These findings confirmed that the Circ_0000423-miRNA-27b-3p-MMP-13 axis could affect the pathogenesis of OA which might lead to a novel target for diagnostic molecular biological indicators and potential OA treatments. +other 35439640 hsa-mir-520a Reperfusion Injury, Cerebral Ischemia CONCLUSION: The study revealed the roles of TTTY15/miR-520a-3p/IRF9 signaling pathway in regulating cerebral ischemia/reperfusion injury. +other 35439323 hsa-mir-93 Diabetes Mellitus, Type 2 5p and maybe involved in the pathogenesis of T2D. +other 35438846 hsa-mir-139 Carcinoma, Hepatocellular 5p negatively regulates the expression of NME1 in HCC cell lines. +lncRNA target 35438468 hsa-mir-155 Carcinoma, Hepatocellular LPS-MIR155HG-PD-L1 regulatory axis provides a new target for the treatment of HCC. +lncRNA target 35438362 hsa-mir-187 Colorectal Neoplasms CircCDC6, acting as a tumor inhibitor, repressed tumor growth and glycolysis metabolism in CRC via targeting the miR +transcription factor target 35437466 hsa-mir-27 Osteoarthritis Ten miRNAs including miR-140, miR-146, miR-34, miR-181, miR-27, miR-9, miR-29, miR-21, miR-26, and miR-155 and chondrocytes were revealed as the most obvious miRNAs and a potential target for OA based on bibliometric analysis. +transcription factor target 35437466 hsa-mir-34 Osteoarthritis Ten miRNAs including miR-140, miR-146, miR-34, miR-181, miR-27, miR-9, miR-29, miR-21, miR-26, and miR-155 and chondrocytes were revealed as the most obvious miRNAs and a potential target for OA based on bibliometric analysis. +transcription factor target 35437466 hsa-mir-9 Osteoarthritis Ten miRNAs including miR-140, miR-146, miR-34, miR-181, miR-27, miR-9, miR-29, miR-21, miR-26, and miR-155 and chondrocytes were revealed as the most obvious miRNAs and a potential target for OA based on bibliometric analysis. +transcription factor target 35437466 hsa-mir-29 Osteoarthritis Ten miRNAs including miR-140, miR-146, miR-34, miR-181, miR-27, miR-9, miR-29, miR-21, miR-26, and miR-155 and chondrocytes were revealed as the most obvious miRNAs and a potential target for OA based on bibliometric analysis. +transcription factor target 35437466 hsa-mir-21 Osteoarthritis Ten miRNAs including miR-140, miR-146, miR-34, miR-181, miR-27, miR-9, miR-29, miR-21, miR-26, and miR-155 and chondrocytes were revealed as the most obvious miRNAs and a potential target for OA based on bibliometric analysis. +transcription factor target 35437466 hsa-mir-26 Osteoarthritis Ten miRNAs including miR-140, miR-146, miR-34, miR-181, miR-27, miR-9, miR-29, miR-21, miR-26, and miR-155 and chondrocytes were revealed as the most obvious miRNAs and a potential target for OA based on bibliometric analysis. +transcription factor target 35437466 hsa-mir-146 Osteoarthritis Ten miRNAs including miR-140, miR-146, miR-34, miR-181, miR-27, miR-9, miR-29, miR-21, miR-26, and miR-155 and chondrocytes were revealed as the most obvious miRNAs and a potential target for OA based on bibliometric analysis. +transcription factor target 35437466 hsa-mir-181 Osteoarthritis Ten miRNAs including miR-140, miR-146, miR-34, miR-181, miR-27, miR-9, miR-29, miR-21, miR-26, and miR-155 and chondrocytes were revealed as the most obvious miRNAs and a potential target for OA based on bibliometric analysis. +transcription factor target 35437466 hsa-mir-140 Osteoarthritis Ten miRNAs including miR-140, miR-146, miR-34, miR-181, miR-27, miR-9, miR-29, miR-21, miR-26, and miR-155 and chondrocytes were revealed as the most obvious miRNAs and a potential target for OA based on bibliometric analysis. +transcription factor target 35437466 hsa-mir-155 Osteoarthritis Ten miRNAs including miR-140, miR-146, miR-34, miR-181, miR-27, miR-9, miR-29, miR-21, miR-26, and miR-155 and chondrocytes were revealed as the most obvious miRNAs and a potential target for OA based on bibliometric analysis. +other 35437351 hsa-mir-149 Aortic Dissection qRT-PCR demonstrated that hsa_circRNA_082317 and ITGA5 were significantly up-regulated, and hsa-miR3p was dramatically down-regulated in AD (n = 3). +circRNA target 35436983 hsa-mir-661 Esophageal Squamous Cell Carcinoma Our findings suggest that circFAM120B is a promising biomarker of ESCC, which acts as a tumor suppressor via the circFAM120B/miR-661/PPM1L axis and PKR/p38 MAPK/EMT pathway, supporting its significance as a candidate therapeutic target. +circulation_biomarker_diagnosis_ns 35436801 hsa-mir-126a Brain Ischemia Pilot Study Investigating Brain Natriuretic Peptide, Troponin, Galectin-3, and OBJECTIVE: The objective was to evaluate the utility of brain natriuretic peptide (BNP), troponin, galectin-3 (Gal-3), and microRNA (miRNA)-126a-5p as screening biomarkers for persistent pulmonary hypertension of the newborn (PPHN) by comparing expression in serum of infants with hypoxic-ischemic injury that develop PPHN to those that do not. +circulation_biomarker_diagnosis_ns 35436801 hsa-mir-126a Persistent Fetal Circulation Syndrome Pilot Study Investigating Brain Natriuretic Peptide, Troponin, Galectin-3, and OBJECTIVE: The objective was to evaluate the utility of brain natriuretic peptide (BNP), troponin, galectin-3 (Gal-3), and microRNA (miRNA)-126a-5p as screening biomarkers for persistent pulmonary hypertension of the newborn (PPHN) by comparing expression in serum of infants with hypoxic-ischemic injury that develop PPHN to those that do not. +other 35436780 hsa-mir-486 Lung Neoplasms This biosensor can absolutely quantify the miR5p expression in different lung cancer cells and distinguish non-small cell lung cancer (NSCLC) patients from healthy individuals, holding great potential in biomedical research and clinical diagnosis. +other 35436733 hsa-mir-106b Squamous Cell Carcinoma of Head and Neck Herein, we proposed a pump-free surface-enhanced Raman scatting (SERS) microfluidic chip for the rapid and ultrasensitive detection of miR-106b and miR-196b, laryngeal squamous cell carcinoma (LSCC)-related miRNAs. +other 35436733 hsa-mir-196b Squamous Cell Carcinoma of Head and Neck Herein, we proposed a pump-free surface-enhanced Raman scatting (SERS) microfluidic chip for the rapid and ultrasensitive detection of miR-106b and miR-196b, laryngeal squamous cell carcinoma (LSCC)-related miRNAs. +other 35436654 hsa-mir-455 Pulmonary Arterial Hypertension CONCLUSIONS: Elevated SOX2-OT is a feasible diagnostic marker for PAH, and its silencing may attenuated hypoxia-induced hPASMCs proliferation, migration, anti-apoptosis, and inflammation by modulating the miR3p/SUMO1 axis, preventing vascular remodeling and PAH progression. +circRNA target 35436629 hsa-mir-222 Diabetic Nephropathies So, the axis of circ608-miR222-PINK1 was proved to participate in NASH-related liver fibrosis by regulating mitophagy. CONCLUSION: Circ608 could promote PINK1-mediated mitophagy of HSCs though inhibiting miR222 in NASH-related liver fibrosis. +circRNA target 35436629 hsa-mir-222 Carcinoma, Hepatocellular So, the axis of circ608-miR222-PINK1 was proved to participate in NASH-related liver fibrosis by regulating mitophagy. CONCLUSION: Circ608 could promote PINK1-mediated mitophagy of HSCs though inhibiting miR222 in NASH-related liver fibrosis. +other 35436578 hsa-mir-193a Neurofibromatosis 2 Moreover, hsa-miR-193a and hsa-miR-504 were identified as specifically upregulated miRNAs in sporadic NF2 and familial NF2, respectively. +other 35436578 hsa-mir-504 Neurofibromatosis 2 Moreover, hsa-miR-193a and hsa-miR-504 were identified as specifically upregulated miRNAs in sporadic NF2 and familial NF2, respectively. +circRNA target 35436516 hsa-mir-490 Glioma 3p/XRCC5/CLC3 ceRNA network, providing a novel prognostic biomarker and a prospective target for glioma treatment. +transcription factor target 35436510 hsa-mir-150 Hypoxia-Ischemia, Brain Our results suggest that NSCs-Ex prevent cerebral injury by transferring miR3p which promotes neurons proliferation by inhibiting CASP2 signaling pathway. +lncRNA target 35436415 hsa-mir-199a Carcinoma, Hepatocellular The dual-luciferase assay showed that miR-199a-3p is not only a target for NRAV but also interacts with the 3' UTR of CISD2 in HCC cells. NRAV may trigger the Wnt/beta-catenin signaling via the modulation of the miR-199a-3p/CISD2 axis in HCC. +circulation_biomarker_diagnosis_ns 35436050 hsa-mir-92a-1 Multiple Sclerosis hsa-miR-454 and hsa-miR-92a-1* relative expression was measured in the plasma of 31 MS patients, relapsing remitting MS (RRMS, n=21) and progressive MS (PMS, n=10) and 20 age and sex matched normal controls by using reverse transcription followed by real time PCR. +circulation_biomarker_prognosis_ns 35436050 hsa-mir-454 Multiple Sclerosis hsa-miR-454 and hsa-miR-92a-1* relative expression was measured in the plasma of 31 MS patients, relapsing remitting MS (RRMS, n=21) and progressive MS (PMS, n=10) and 20 age and sex matched normal controls by using reverse transcription followed by real time PCR. +circulation_biomarker_diagnosis_ns 35435753 hsa-mir-451a Tuberculosis The baseline circulating levels of hsa-miR +circulation_biomarker_diagnosis_ns 35435604 hsa-mir-4442 Coronary Artery Disease 5p, and miR-6069 that were differentially expressed in peripheral blood mononuclear cells of coronary artery disease (CAD) patients vs. controls. +circulation_biomarker_diagnosis_ns 35435604 hsa-mir-197 Coronary Artery Disease 5p, and miR-6069 that were differentially expressed in peripheral blood mononuclear cells of coronary artery disease (CAD) patients vs. controls. +circulation_biomarker_diagnosis_ns 35435604 hsa-mir-24 Coronary Artery Disease 5p, and miR-6069 that were differentially expressed in peripheral blood mononuclear cells of coronary artery disease (CAD) patients vs. controls. +circulation_biomarker_diagnosis_ns 35435604 hsa-mir-6069 Coronary Artery Disease 5p, and miR-6069 that were differentially expressed in peripheral blood mononuclear cells of coronary artery disease (CAD) patients vs. controls. +circulation_biomarker_diagnosis_ns 35435604 hsa-mir-6879 Coronary Artery Disease 5p, and miR-6069 that were differentially expressed in peripheral blood mononuclear cells of coronary artery disease (CAD) patients vs. controls. +lncRNA target 35435532 hsa-mir-130b Intervertebral Disc Degeneration These data demonstrated that the miR-130b-3p inhibition could upregulate the autophagic flux and alleviate the IVDD via targeting ATG14 and PRKAA1.The translational potential of this article: The suppression of miR-130b-3p may become an effective therapeutic strategy for IVDD. +lncRNA target 35435136 hsa-mir-183 Adenocarcinoma of Lung 5p, and regulates LATS1 to activate Hippo/YAP pathway, thereby inhibiting the process of LUAD cells. +other 35435133 hsa-mir-138 Vascular Calcification In conclusion, this study demonstrates that the H19/miR-138/TLR3 axis is involved in high phosphorus-mediated vascular calcification in rats with CKD. +other 35435133 hsa-mir-138 Renal Insufficiency, Chronic In conclusion, this study demonstrates that the H19/miR-138/TLR3 axis is involved in high phosphorus-mediated vascular calcification in rats with CKD. +other 35435130 hsa-mir-181a Squamous Cell Carcinoma of Head and Neck Quantitative real-time PCR and Western blotting were conducted for detecting the expressions of LINC00847, microRNA-181a-5p (miR-181a-5p) and zinc finger E-box binding homeobox 2 (ZEB2) in LSCC cell lines and tissue samples. Our data suggest that LINC00847 promotes LSCC progression by regulating the miR-181a-5p/ZEB2 axis. +lncRNA target 35435120 hsa-mir-421 Cholangiocarcinoma These findings demonstrate that circSETD3 inhibits proliferation and induces apoptosis in CCA cells by regulating the miR-421/BMF axis, indicating its potential as a promising candidate for CCA therapy. +genetics_knock down_promote 35435118 hsa-mir-5590 Esophageal Neoplasms 3p suppression could abrogate the functional effects of BLACAT1 knockdown on EC cells; while PD-L1 silencing partly abolished the promoting effects of miR +genetics_knock down_promote 35435118 hsa-mir-5590 Urinary Bladder Neoplasms 3p suppression could abrogate the functional effects of BLACAT1 knockdown on EC cells; while PD-L1 silencing partly abolished the promoting effects of miR +circRNA target 35435117 hsa-mir-489 Stomach Neoplasms AS-IV inhibited the development of GC through circDLST/miR +genetics_knock down_suppress 35435110 hsa-mir-613 Uterine Cervical Neoplasms Knockdown of circ_0001823 inhibited the malignant behaviors of the CC cells via regulating the miR-613/RAB8A axis. +genetics_knock down_promote 35435107 hsa-mir-6888 Osteosarcoma Changes in the proliferation and migration of OS cells were detected by Cell Counting Kit-8 (CCK-8) and transwell assays after the knockdown of HOTAIR, miR +genetics_overexpression_suppress 35435104 hsa-mir-27a Cylindromatosis LncRNA GAS5 overexpression inhibited proliferation of PitNETs cell line MMQ and GH3 cells and induced cell apoptosis, simultaneously, inhibited miR-27a-5p expression and increased CYLD expression. +genetics_overexpression_promote 35434854 hsa-mir-4701 Colorectal Neoplasms 5p to overexpress TUSC1, indicating that the circ_PLXNB1/miR +genetics_GWAS 35434480 hsa-mir-23b Abortion, Habitual OBJECTIVE: We surveyed the association between polymorphisms in pre-miR-125a, pre-miR-10a, pre-miR-323b, GPX4, and GPX4 in Iranian women with idiopathic RPL. +genetics_GWAS 35434480 hsa-mir-10a Abortion, Habitual RESULTS: The frequencies of polymorphisms in pre-miR-125a (p < 0.001) and pre-miR-10a (p = 0.04) were calculated among the case and control groups, which showed a statistical difference (p < 0.05), indicating an association between these polymorphisms and the symptoms of RPL. +genetics_GWAS 35434480 hsa-mir-125a Abortion, Habitual RESULTS: The frequencies of polymorphisms in pre-miR-125a (p < 0.001) and pre-miR-10a (p = 0.04) were calculated among the case and control groups, which showed a statistical difference (p < 0.05), indicating an association between these polymorphisms and the symptoms of RPL. +lncRNA target 35434335 hsa-mir-144 Squamous Cell Carcinoma of Head and Neck CONCLUSION: CircLPAR3 exerted a tumor-promoting effect on OSCC growth through elevating LPCAT1 expression via functioning as a miR +other 35434044 hsa-mir-371a Atherosclerosis This article will explore the role of the lncRNA COLCA1 (colorectal cancer associated 1)/hsa-miR-371a-5p/SPP1 (secreted phosphoprotein 1) pathway in oxLDL in causing human coronary artery endothelial cells (HCAECs) inflammation and related biological function changes. +other 35434020 hsa-mir-146a Conjunctivitis, Allergic CONCLUSIONS: We demonstrated a possible protective mechanism by the miR-146a/HIPK3/STAT3 axis, by which decrease of miR-146a could aggravate the inflammation of AC. +lncRNA target 35433983 hsa-mir-19a Carcinoma, Pancreatic Ductal Subsequently, we found that miR-19a-3p binds to TBK1 in PDAC and LINC00483 could regulate PDAC cell progression by regulating miR-19a-3p via the TBK1/MAPK pathway. CONCLUSIONS: The results of our study suggested that the LINC00483/miR-19a-3p/TBK1/MAPK axis contributed to PDAC progression, which provides a potential therapeutic target for PDAC treatment. +lncRNA target 35433983 hsa-mir-19a Pancreatic Carcinoma Subsequently, we found that miR-19a-3p binds to TBK1 in PDAC and LINC00483 could regulate PDAC cell progression by regulating miR-19a-3p via the TBK1/MAPK pathway. CONCLUSIONS: The results of our study suggested that the LINC00483/miR-19a-3p/TBK1/MAPK axis contributed to PDAC progression, which provides a potential therapeutic target for PDAC treatment. +other 35433971 hsa-mir-198 Aortic Aneurysm RT-qPCR and TSA-ISH assays showed the upregulation of miR-4306 and the downregulation of miR-3198 in AA tissue samples. +other 35433971 hsa-mir-4306 Aortic Aneurysm RT-qPCR and TSA-ISH assays showed the upregulation of miR-4306 and the downregulation of miR-3198 in AA tissue samples. +genetics_overexpression_promote 35433959 hsa-mir-28 Carcinoma, Non-Small-Cell Lung Overexpressed miR +transcription factor target 35433958 hsa-mir-129 Dmd-Associated Dilated Cardiomyopathy CONCLUSIONS: In conclusion, we speculate that miR5p might target ASPN in regulating DCM via the ECM signaling pathway. +other 35433957 hsa-mir-3163 Pancreatic Carcinoma Mechanistically, DBH-AS1 was able to increase PC cell sensitivity to gemcitabine by sequestering miR-3163 and thus upregulating USP44 in these tumor cells. +lncRNA target 35433915 hsa-mir-29c Epstein-Barr Virus Infections The functional enrichment of the above DEGs indicates that miR-29c is a potential regulator of oxidative stress and inflammatory response in bMECs through multiple genes, such as forkhead box O1 (FOXO1), tumor necrosis factor-alpha (TNF-alpha), and major histocompatibility complex, class II, DQ alpha 5 (BoLA-DQA5) in the various biological process and signaling pathways of stress-activated mitogen-activated protein kinase (MAPK) cascade, Epstein-Barr virus infection, inflammatory bowel disease, etc. +lncRNA target 35433915 hsa-mir-29c Inflammatory Bowel Diseases The functional enrichment of the above DEGs indicates that miR-29c is a potential regulator of oxidative stress and inflammatory response in bMECs through multiple genes, such as forkhead box O1 (FOXO1), tumor necrosis factor-alpha (TNF-alpha), and major histocompatibility complex, class II, DQ alpha 5 (BoLA-DQA5) in the various biological process and signaling pathways of stress-activated mitogen-activated protein kinase (MAPK) cascade, Epstein-Barr virus infection, inflammatory bowel disease, etc. +transcription factor target 35433915 hsa-mir-29c Mastitis The results imply that miR-29c plays an important role in a steady state of bMECs or cow mammary gland and may be a potential therapeutic target for mastitis in dairy cows. +epigenetics 35433692 hsa-mir-211 Anxiety Disorders 5p via Trpm1 demethylation, and miR +lncRNA target 35433661 hsa-mir-195 Esophageal Squamous Cell Carcinoma Conclusion: In summary, elevated LINC00662 transferred by ESCC cells-derived EVs induces angiogenesis through downregulating miR +target gene 35433535 hsa-mir-34a Bronchopulmonary Dysplasia Hyperoxia Induced Bronchopulmonary Dysplasia-Like Inflammation via miR34a-TNIP2-IL-1β Pathway. +other 35433464 hsa-mir-139 Breast Neoplasms miR-139-5p Was Identified as Biomarker of Different Molecular Subtypes of Breast Carcinoma. +circulation_biomarker_prognosis_ns 35433428 hsa-mir-199a Uveal melanoma 5p (p < 0.001) were found in serum of metastatic UM patients compared to patients with localized spindle-shaped melanoma, and significantly higher levels of miR-199a-3p (p < 0.001) were detected in serum of metastatic UM patients compared to healthy controls. +circulation_biomarker_diagnosis_up 35433428 hsa-mir-214 Uveal melanoma 3p and, conversely, were significantly downregulated in serum of epithelioid cell melanoma patients. +circulation_biomarker_prognosis_ns 35433428 hsa-mir-21 Uveal melanoma Our preliminary data indicate promising diagnostic utility of circulating miR-199a-3p and promising prognostic utility of circulating miR +genetics_overexpression_suppress 35433237 hsa-mir-1266 Colonic Neoplasms 3p inhibited the growth and metastasis of colon cancer in vitro as well as in vivo, and this effect could be alleviated by overexpressing P4HA3. +circulation_biomarker_diagnosis_ns 35432916 hsa-mir-214 Parkinson Disease 5p, and mir-214 was observed in the serum and CSF which may be established as a biomarker for the diagnosis of PD. +circulation_biomarker_diagnosis_ns 35432916 hsa-mir-31 Parkinson Disease 5p, and mir-214 was observed in the serum and CSF which may be established as a biomarker for the diagnosis of PD. +circulation_biomarker_diagnosis_ns 35432916 hsa-mir-485 Parkinson Disease 5p, and mir-214 was observed in the serum and CSF which may be established as a biomarker for the diagnosis of PD. +circulation_biomarker_diagnosis_ns 35432916 hsa-mir-24 Parkinson Disease 5p, and mir-214 was observed in the serum and CSF which may be established as a biomarker for the diagnosis of PD. +circulation_biomarker_diagnosis_ns 35432916 hsa-mir-151a Parkinson Disease 5p, and mir-214 was observed in the serum and CSF which may be established as a biomarker for the diagnosis of PD. +other 35432732 hsa-mir-224 Cardiomyopathies We showed miRNA224-5p, the most upregulated miRNA in HP-EVs, directly combined the 3' untranslated region of TXNIP and demonstrated its critical protective role against hypoxia-mediated CM injury. +transcription factor target 35432725 hsa-mir-199a Diabetic Foot miR-199a-5p and its targets showed therapeutic effect on diabetic wounds. +exosome 35432524 hsa-mir-133a Carcinoma, Hepatocellular We examined the metastatic ability of HCC cells after IL-6 treatment and found that miR-133a-3p was sorted into exosomes after IL-6 stimulation and was subsequently released into the tumor microenvironment. In vitro analysis confirmed that exosomal miR-133a-3p acted as a tumor suppressor in HCC. +lncRNA target 35432472 hsa-mir-372 Colonic Neoplasms 3p Functions as a Tumor Suppressor in Colon Cancer by Targeting MAP3K2. +other 35432462 hsa-mir-126 Hypertension We identified the combination of miR3p and 126-5p as potential endogenous control in studies of hypertension. +other 35432462 hsa-mir-223 Hypertension We identified the combination of miR3p and 126-5p as potential endogenous control in studies of hypertension. +other 35432445 hsa-mir-617 Prostatic Neoplasms Using normal tissue models, we identified two significant TWAS microRNA associations with PrCa risk: over-expression of mir-941 family microRNAs (P(TWAS) = 2.9E-04) and reduced expression of miR5p (P(TWAS) = 1.0E-03). +other 35432445 hsa-mir-941 Prostatic Neoplasms Using normal tissue models, we identified two significant TWAS microRNA associations with PrCa risk: over-expression of mir-941 family microRNAs (P(TWAS) = 2.9E-04) and reduced expression of miR5p (P(TWAS) = 1.0E-03). +other 35432384 hsa-mir-181d Sjogren's Syndrome Further dissection of the pathophysiological mechanisms underlying the hsa-miR-181d-5p-mediated action in inflammatory conditions could be useful to evaluate the benefits of increasing hsa-miR-181d-5p levels for restoration of salivary gland epithelial cell architecture and function. +circulation_biomarker_diagnosis_ns 35432357 hsa-mir-144 Asthma 3p is associated with severe diseases in both the airways and serum of asthmatics, and this association is related to corticosteroid treatment. +other 35432149 hsa-mir-204 Myasthenia Gravis with Thymus Hyperplasia CONCLUSIONS: In this research, we constructed a ceRNA network involved in the progression of TAMG, discovered that thymic Tregs were significantly decreased in patients with TAMG, and assumed that the LINC00452/miR-204/CHST4 axis may regulate thymic Tregs in the development of TAMG. +genetics_overexpression_promote 35431959 hsa-mir-133c Arthritis Overexpression of NR-133666 and MAPK1 can promote the proliferation and migration of CIA FLS, and overexpression of miR-133c can reverse this phenomenon. Collectively, we identified that lncRNA NR-133666 acted as a miR-133c sponge that can promote the proliferation and migration of CIA FLS through regulating the miR-133c/MAPK1 axis. +other 35431948 hsa-mir-199 Lung Injury Conclusion: Paraquat induces ALI by affecting miRmediated SET. +other 35431233 hsa-mir-497 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: ELFN1-AS1 acts as an independent prognostic biomarker and tumor promoter of NSCLC by sponging miR-497/CCNE1 axis. +circulation_biomarker_diagnosis_ns 35431230 hsa-mir-195 Adenocarcinoma of Lung MiR-15b-3p, miR-148a-3p, miR-193b-3p, and miR5p were significantly deregulated in plasma samples of LUAD patients compared to donors. +circulation_biomarker_diagnosis_ns 35431230 hsa-mir-15b Adenocarcinoma of Lung MiR-15b-3p, miR-148a-3p, miR-193b-3p, and miR5p were significantly deregulated in plasma samples of LUAD patients compared to donors. +circulation_biomarker_diagnosis_ns 35431230 hsa-mir-193b Adenocarcinoma of Lung MiR-15b-3p, miR-148a-3p, miR-193b-3p, and miR5p were significantly deregulated in plasma samples of LUAD patients compared to donors. +circulation_biomarker_diagnosis_ns 35431230 hsa-mir-148a Adenocarcinoma of Lung MiR-15b-3p, miR-148a-3p, miR-193b-3p, and miR5p were significantly deregulated in plasma samples of LUAD patients compared to donors. +lncRNA target 35430766 hsa-mir-125b Drug Hypersensitivity We evaluate the anti-cancer activity of two novel RIG-I agonists, the immunomodulatory RNA (immRNA) with a unique secondary structure for efficient RIG-I activation, and a 5' triphosphorylated antisense oligonucleotide with dual function of RIG-I activation and miR-125b inhibition (3p-125b-ASO). +genetics_knock down_promote 35430713 hsa-mir-381 Uterine Cervical Neoplasms FLVCR1-AS1 or MAGT1 knockdown or miR +lncRNA target 35430618 hsa-mir-1227 Fetal Growth Retardation 3p may participate in the development of FGR via regulating trophoblast cell proliferation and apoptosis by targeting genes involved in the insulin pathway. +lncRNA target 35430304 hsa-mir-99a Obesity CONCLUSIONS: MIR99AHG enhances adipogenesis by regulating miR-29b-3p and PPARgamma, providing a new target for therapeutic intervention in obesity. +circulation_biomarker_diagnosis_up 35430138 hsa-mir-2909 Urinary Bladder Neoplasms On multivariate analysis, serum free testosterone (hazards ratio [HR]: 8.9; 95% CI: 1.8-45.1; P=0.008), serum AR1 (HR: 0.5; 95% CI: 0.3-0.9; P=0.02), and plasma miRNA-2909 (HR: 5.8; 95% CI: 2.3-14.7; P=0.0002), and tissue AR2 (HR: 2.6; 95% CI: 1.4-4.7; P=0.002) were independent predictor for NMIBC recurrence. +lncRNA target 35429679 hsa-mir-1538 Colorectal Neoplasms Functional and mechanism experiments showed that miR-1538 decreased the protein level of DNA methyltransferases 3A (DNMT3A) and inhibited the proliferation, migration and invasion of CRC cells by targeting the 3'-UTR of DNMT3A mRNA. +genetics_knock down_suppress 35429078 hsa-mir-411 Carcinoma, Hepatocellular 5p reversed STAT3 and PD-L1 expression inhibited by MIAT knockdown in HCC cells. +genetics_overexpression_promote 35428780 hsa-mir-15a Cholangiocarcinoma Overexpression of miR-15a-5p promoted apoptosis but suppressed malignancy and tumorigenicity of CCA cells as well as EMT through downregulating CHEK1. +circRNA target 35428519 hsa-mir-874 Nasopharyngeal Carcinoma 3p alleviated the suppressive effects of circ_0081534 silencing on NPC cell malignant phenotypes. +other 35428200 hsa-mir-374b Arteriosclerosis Obliterans 5p (p: < 0.0001; < 0.0001; < 0.0001), and miR-150 (p: < 0.0001; < 0.0001; 0.0001) showed downregulated expression in patients with ASO. +other 35428200 hsa-mir-21 Arteriosclerosis Obliterans 5p (p: < 0.0001; < 0.0001; < 0.0001), and miR-150 (p: < 0.0001; < 0.0001; 0.0001) showed downregulated expression in patients with ASO. +other 35428200 hsa-mir-29b Arteriosclerosis Obliterans 5p (p: < 0.0001; < 0.0001; < 0.0001), and miR-150 (p: < 0.0001; < 0.0001; 0.0001) showed downregulated expression in patients with ASO. +other 35428200 hsa-mir-150 Arteriosclerosis Obliterans 5p (p: < 0.0001; < 0.0001; < 0.0001), and miR-150 (p: < 0.0001; < 0.0001; 0.0001) showed downregulated expression in patients with ASO. +other 35428200 hsa-mir-142 Arteriosclerosis Obliterans 5p (p: < 0.0001; < 0.0001; < 0.0001), and miR-150 (p: < 0.0001; < 0.0001; 0.0001) showed downregulated expression in patients with ASO. +genetics_overexpression_promote 35427992 hsa-mir-223 Sezary Syndrome Consequently, overexpression of miR +other 35427886 hsa-mir-381 Attention Deficit Disorder with Hyperactivity Although microRNAs (miRNAs) exert an important role in the osteogenesis of mesenchymal stem cells (MSCs), the effect of miR3p on the osteogenic differentiation in MBDMSCs is still unclear. +other 35427886 hsa-mir-381 Multiple Mitochondrial Dysfunctions Syndrome Although microRNAs (miRNAs) exert an important role in the osteogenesis of mesenchymal stem cells (MSCs), the effect of miR3p on the osteogenic differentiation in MBDMSCs is still unclear. +genetics_overexpression_promote 35427425 hsa-mir-1306 Melanoma Functional assays further sustained that overexpressed miR +genetics_overexpression_promote 35427373 hsa-mir-542 Colorectal Neoplasms Thus, we further verified that overexpression of integrin-linked kinase on down-regulated long non-coding RNA cancer susceptibility candidate 9 or up-regulated miR +genetics_knock down_suppress 35426617 hsa-mir-410 Colorectal Neoplasms Furthermore, circTMEM59 inhibited CRC tumor growth by overexpressing HOXD8 through sponging miR +other 35426476 hsa-mir-124 Alzheimer Disease 3p/BACE1 pathway modulation is critically involved in Pb-induced AD-like amyloidogenic processing. +transcription factor target 35426328 hsa-mir-224 Carcinoma, Hepatocellular CONCLUSION: PS-T increases the sensitivity of human hepatoma cells to OXA via the miR5p/ABCB1/P-gp axis. +other 35426258 hsa-mir-34c Parkinson Disease CONCLUSION: Our study first proved LINC00667, miR-34c-5p, and HNF4A constructed a positive feedback loop in MPP(+) -treated SH-SY5Y cells, enriching our understanding of PD. +lncRNA target 35426242 hsa-mir-429 Adenocarcinoma of Lung LINC00365, miR-429, and KCTD12 expression in the LAD clinical tissues and cells were detcetd by qRT-PCR and Western blot. Thus, LINC00365 inhibited LAD progression and glycolysis via targeting miR-429/KCTD12 axis. +circulation_biomarker_diagnosis_ns 35426182 hsa-mir-125b Sepsis RESULTS: In the serum of sepsis patients and lipopolysaccharide(LPS)-induced U937 cells, MALAT1, STAT3, and PCT gene expression levels were significantly increased, while miR-125b expression level was decreased. +other 35425712 hsa-mir-10a Kidney Neoplasms BAP1-Related ceRNA (NEAT1/miR-10a-5p/SERPINE1) Promotes Proliferation and Migration of Kidney Cancer Cells. +other 35424703 hsa-mir-155 Breast Neoplasms Their over-expression correlates with various pathologies: for instance, miRNA-155 (miR-155) is over-expressed upon the development of breast cancers. +lncRNA target 35422914 hsa-mir-199a Triple Negative Breast Neoplasms Ectopic miR-199a-3p in TNBC cells exerted inhibitory effects on cell proliferation, migration and xenograft tumor growth. +genetics_knock down_suppress 35422898 hsa-mir-124 Retinoblastoma miR-124 inhibition or c-myc overexpression partially reversed the effects of UCA1 knockdown on retinoblastoma cells. Overall, lncRNA UCA1 may exert an oncogenic effect on retinoblastoma progression through the miR-124/c-myc axis, which might serve as a promising retinoblastoma treatment target. +genetics_overexpression_suppress 35422889 hsa-mir-532 Osteosarcoma 3p overexpression inhibits luciferase activity of DARS-AS1-WT, not DARS-AS1-MUT in MG-63 cell. +other 35422846 hsa-mir-142 Myocardial Infarction, Acute 3p/BCL6 axis. +other 35422846 hsa-mir-139 Myocardial Infarction, Acute 3p/BCL6 axis. +other 35422846 hsa-mir-545 Myocardial Infarction, Acute 3p/BCL6 axis. +other 35422840 hsa-mir-27a familial temporal lobe epilepsy 3 miR-27a-3p was capable of regulating multiple mTLE ion channel-related DEGs. Moreover, the network of miR-27a-3p regulating ion channel genes will be of great value in mTLE. +other 35422807 hsa-mir-21 Neuroaxonal Dystrophies Our findings suggest a contributory role of miR-21 and miR-690 in TCE-mediated and its metabolite dichloroacetyl chloride (DCAC)-mediated inflammation and autoimmune response and support that antioxidant SFN could be a potential therapeutic candidate for inflammatory responses and ADs. +other 35422807 hsa-mir-21 Autoimmune Diseases Based on the microarray findings, we subsequently focused on two miRNAs (miRNA-21 and miRNA-690), which are known to be involved in inflammation and autoimmune response. Our findings suggest a contributory role of miR-21 and miR-690 in TCE-mediated and its metabolite dichloroacetyl chloride (DCAC)-mediated inflammation and autoimmune response and support that antioxidant SFN could be a potential therapeutic candidate for inflammatory responses and ADs. +other 35422807 hsa-mir-690 Inflammation Our findings suggest a contributory role of miR-21 and miR-690 in TCE-mediated and its metabolite dichloroacetyl chloride (DCAC)-mediated inflammation and autoimmune response and support that antioxidant SFN could be a potential therapeutic candidate for inflammatory responses and ADs. +other 35422807 hsa-mir-21 Inflammation Based on the microarray findings, we subsequently focused on two miRNAs (miRNA-21 and miRNA-690), which are known to be involved in inflammation and autoimmune response. Our findings suggest a contributory role of miR-21 and miR-690 in TCE-mediated and its metabolite dichloroacetyl chloride (DCAC)-mediated inflammation and autoimmune response and support that antioxidant SFN could be a potential therapeutic candidate for inflammatory responses and ADs. +other 35422807 hsa-mir-690 Neuroaxonal Dystrophies Our findings suggest a contributory role of miR-21 and miR-690 in TCE-mediated and its metabolite dichloroacetyl chloride (DCAC)-mediated inflammation and autoimmune response and support that antioxidant SFN could be a potential therapeutic candidate for inflammatory responses and ADs. +other 35422807 hsa-mir-690 Autoimmune Diseases Our findings suggest a contributory role of miR-21 and miR-690 in TCE-mediated and its metabolite dichloroacetyl chloride (DCAC)-mediated inflammation and autoimmune response and support that antioxidant SFN could be a potential therapeutic candidate for inflammatory responses and ADs. +other 35422654 hsa-mir-486 Arthritis, Rheumatoid 5p-XIST) related to the pathogenesis of RA. +other 35422654 hsa-mir-1226 Arthritis, Rheumatoid 5p-XIST) related to the pathogenesis of RA. +other 35422654 hsa-mir-5581 Arthritis, Rheumatoid 5p-XIST) related to the pathogenesis of RA. +other 35422654 hsa-mir-338 Arthritis, Rheumatoid 5p-XIST) related to the pathogenesis of RA. +exosome 35422485 hsa-mir-182 Myocardial Reperfusion Injury Furthermore, MSC-derived exosomes carrying miR5p improved cardiac function and reduced myocardial infarction, accompanied with reduced inflammation and cell pyroptosis in vivo. +genetics_GWAS 35422450 hsa-mir-181b Crohn Disease CONCLUSIONS: In conclusion, our study demonstrated that two SNPs, rs322931 (C>T) in miR-181b and rs7158663 (G>A) in MEG3, could aggravate the inflammatory response of anal abscess in patients with Crohn's disease via modulating the MEG3/miR-181b/TNF-alpha signaling pathway. +transcription factor target 35422233 hsa-mir-7 Diabetes, Gestational CONCLUSION: Thus, an elevated level of miRNA7 may be associated with the progression of GDM by altering the multiple pathways like insulin, GnRH, and inflammatory signaling pathways via targeting IRS1, IRS2, and RAF1, implicating a new therapeutic target for GDM. +genetics_overexpression_promote 35422021 hsa-mir-377 Osteoarthritis RESULTS: PRNCR1 was overexpressed in OA, while miR +exosome 35421904 hsa-mir-17 Ischemic Stroke Alterations of miRNA-17 family and miRNA92 cluster were identified in preclinical, clinical and MSC-EV-mediated neuroprotection in experimental stroke. +genetics_overexpression_suppress 35421879 hsa-let-7a Breast Neoplasms In response to the overexpressed miR-155 in breast cancer cells, the hybrids disintegrate and release let-7a and the complementary DNA of miR-155 to inhibit the expression of HMGA1 and relieve the inhibition of SOX1, respectively. +genetics_overexpression_suppress 35421879 hsa-mir-155 Breast Neoplasms In response to the overexpressed miR-155 in breast cancer cells, the hybrids disintegrate and release let-7a and the complementary DNA of miR-155 to inhibit the expression of HMGA1 and relieve the inhibition of SOX1, respectively. +circulation_biomarker_prognosis_up 35421866 hsa-mir-138 Cerebral Infarction, Acute The ROC curve demonstrated the diagnostic potential of serum miR +transcription factor target 35421737 hsa-mir-449c Sepsis RT-PCR, Western blotting, ELISA, CCK8, EDU and luciferase reporter genes were used to verify whether miR-449c-5p could alleviate the apoptosis of vascular endothelial cells and the release of inflammatory factors during the progression of sepsis by inhibiting the expression of TAK1. +circulation_biomarker_diagnosis_ns 35421672 hsa-mir-21 hereditary diffuse gastric cancer The receiver operating characteristic curve generated during clinical sample analysis indicates that the exosomal miR-21 outperforms serum carcinoembryonic antigen in discriminating between patients with gastric cancer (GC) and patients with precancerous (PC) lesions (area under the curve: 0.89 versus 0.74, n = 40). +circulation_biomarker_diagnosis_ns 35421672 hsa-mir-21 Corneal dystrophy, epithelial basement membrane The receiver operating characteristic curve generated during clinical sample analysis indicates that the exosomal miR-21 outperforms serum carcinoembryonic antigen in discriminating between patients with gastric cancer (GC) and patients with precancerous (PC) lesions (area under the curve: 0.89 versus 0.74, n = 40). +circulation_biomarker_diagnosis_ns 35421672 hsa-mir-21 Precancerous Conditions The receiver operating characteristic curve generated during clinical sample analysis indicates that the exosomal miR-21 outperforms serum carcinoembryonic antigen in discriminating between patients with gastric cancer (GC) and patients with precancerous (PC) lesions (area under the curve: 0.89 versus 0.74, n = 40). +genetics_knock down_promote 35421264 hsa-mir-26a Nasopharyngeal Carcinoma CONCLUSION: LINC00240 knockdown restrained cell proliferation, invasion, migration, and angiogenesis, while it advanced apoptosis via miR-26a-5p in NPC by EZH2 inhibition. +other 35421166 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck For miR-21 detection, matched tissue samples from 30 head and neck squamous cell carcinoma (HNSCC) patients and 8 head and neck cancer (HNC) cell lines were obtained. Compared to the corresponding normal control (NC) tissues, 25 cancer tissues had miR-21 upregulation among the 30 matched pair tissues (25/30, 83.8%); furthermore, among the 8 HNC cell lines, miR-21 expression that was notably upregulated in three: UPCI-4B, UMSCC-1, and UPCI-15B. +circulation_biomarker_diagnosis_up 35421066 hsa-mir-148a Pre-Eclampsia To study the relationship between miR-148a and preeclampsia (PE), and clarify that miR-148a can regulate the endoplasmic reticulum stress (ERS) of placental trophoblasts by targeting the ERS protein X box binding protein 1 (XBP1).Fifty patients with hypertension during pregnancy, patients with mild PE, patients with severe PE, and normal pregnant women were selected, and their placental tissues were collected. GRP78, CHOP, and caspase-12 expression result in anti-miR-148a group was decreased.miR-148a can regulate the ERS-mediated apoptosis by targeting XBP1, thereby intervening in the occurrence and development of PE. +genetics_knock down_promote 35420507 hsa-mir-4284 Uterine Cervical Neoplasms However, the inhibitory effect of PGM5-AS1 overexpression on CC cells was partly relieved by DCN knockdown because of the targeting interaction between PGM5-AS1, miR-4284, and DCN. +lncRNA target 35420127 hsa-mir-124 Cleft Palate 5p inhibitors rescued atRA-induced CP with almost complete penetrance. +genetics_GWAS 35419790 hsa-mir-124 Leiomyoma This study demonstrates that MED12 exon 2 mutations and probably microRNA-124 gene expressions might contribute to uterine leiomyoma pathology. +lncRNA target 35419295 hsa-mir-497 Nasopharyngeal Carcinoma Mechanism research confirmed CASC9 regulated the malignant biological behavior of nasopharyngeal carcinoma cells by targeting miR5p/Wnt3a/beta-catenin signaling pathway. +genetics_overexpression_suppress 35419056 hsa-mir-129 Triple Negative Breast Neoplasms 5p or overexpression of POM121 reversed the inhibitory effect of sh-circints4 on the development of ADR-resistant TNBC cells. +other 35419033 hsa-mir-19b Metabolic Diseases Unexpectedly, in the same line of experiments, sperm RNA from animals raised on a normal diet when mixed with the sperm RNA from animals raised on a diet high in fat or synthetic miR-19b (inducer of obesity) affects or prevents the development of obesity and diabetes. +other 35418653 hsa-mir-6777 Glaucoma 5p was commonly downregulated in both PEX glaucoma and NTG patients. +other 35418237 hsa-mir-126 Vascular Diseases For vascular tissues, miR-126 is one of the most important regulators and might have substantial application potential in maintaining vascular homeostasis. +lncRNA target 35418193 hsa-mir-130b Pancreatic Carcinoma In conclusion, the current study indicated that LINC00857 promotes PC tumorigenesis and metastasis by modulating the miR-130b/RHOA axis, implying that LINC00857 might be a new therapeutic target for PC. +genetics_overexpression_promote 35418191 hsa-mir-5581 Urinary Bladder Neoplasms 3p partially rescued the effects of the overexpressing SMAD3 and FTO in BCa cells. +other 35418181 hsa-mir-92a Osteolysis In summary, our study suggests the key role of miR-92a/KLF4/p110delta signal in TiPs-induced macrophages inflammation and osteolysis. +circRNA target 35418175 hsa-mir-510 Gastric Cancer, Early In summary, our study demonstrated that a higher level of circFNDC3B could lead to the increased expression of CD44 and CDH1 via modulating the signaling pathways of miR-942/CD44 and miR-510/CDH1 in EGC patients. +circRNA target 35418175 hsa-mir-942 Gastric Cancer, Early In summary, our study demonstrated that a higher level of circFNDC3B could lead to the increased expression of CD44 and CDH1 via modulating the signaling pathways of miR-942/CD44 and miR-510/CDH1 in EGC patients. +circulation_biomarker_diagnosis_up 35418162 hsa-mir-526b Glioblastoma In GBM cells, HOTAIR competitively bound to miR-526b-3p and weakened miR-526b-3p's binding ability to EVA1, thus increasing the expression of EVA1. GBM-serum-EV-enclosed HOTAIR may augment GBM progression and chemoresistance through miR-526b-3p downregulation and EVA1 upregulation. +genetics_overexpression_suppress 35417749 hsa-mir-1294 Carcinoma, Hepatocellular Overexpression of IRGQ restored miR +genetics_GWAS 35417465 hsa-mir-21 Fatty Liver In conclusions, the anti-steatotic, insulin-sensitizing, glucose-lowering and lipotropic potencies of folic acid in NAFL rats may be linked to the epigenetic modulation of the hepatic microRNAs (miR-21, -34a, and -122) and the expression of their target genes (HBP1, SIRT1, and SREBP-1c). +transcription factor target 35417465 hsa-mir-122 Fatty Liver Our current work aimd to explore the possible ameliorative potency of folic acid and its association with the hepatic miR-21, -34a, and -122 expression as well as their targeted genes, HBP1, SIRT1, and SREBP-1c in rats with non-alcoholic fatty liver disease (NAFL). +transcription factor target 35417465 hsa-mir-34a Fatty Liver Our current work aimd to explore the possible ameliorative potency of folic acid and its association with the hepatic miR-21, -34a, and -122 expression as well as their targeted genes, HBP1, SIRT1, and SREBP-1c in rats with non-alcoholic fatty liver disease (NAFL). +lncRNA target 35416858 hsa-mir-126 Myocardial Reperfusion Injury CONCLUSIONS: Naringin preconditioning can reduce myocardial I/R injury via regulating miR-126/GSK-3beta/beta-catenin signaling pathway, and this chemical can be used to treat acute myocardial infarction. +transcription factor target 35416554 hsa-mir-145 Cardiomyopathies CONCLUSION: These results indicated that miR-145 upregulation could improve cardiac dysfunction and cardiac fibrosis by inhibiting MAP3K3 in heart failure. Thus, upregulating miR-145 or blocking MAP3K3 can be used to treat heart failure and cardiac fibrosis. +lncRNA target 35416273 hsa-mir-384 Neurotoxicity Syndromes 5p regulates ketamine-induced neurotoxicity in hippocampal neurons by targeting GABRB1. +lncRNA target 35416269 hsa-mir-29c Reperfusion Injury, Cerebral Ischemia CONCLUSION: Our findings show that LINC01296 can alleviate the injury induced by cerebral ischemia and reimplantation by preventing the inhibitory effect of miR-29c on Birc2 and Bak1. +genetics_overexpression_suppress 35416128 hsa-mir-1306 Colorectal Neoplasms Overexpression of miR +genetics_overexpression_promote 35416122 hsa-mir-18 Stomach Neoplasms In this research, gastric cancer cell lines with stable overexpression of miR-18 were constructed through lentivirus infection. +other 35415740 hsa-mir-7111 Esophageal Squamous Cell Carcinoma 5p both showed lower expression levels in ESCC patients than those in healthy individuals. +other 35415740 hsa-mir-6763 Esophageal Squamous Cell Carcinoma 5p both showed lower expression levels in ESCC patients than those in healthy individuals. +transcription factor target 35415462 hsa-mir-92b Acquired Immunodeficiency Syndrome Our findings also suggest that out of a pool of dysregulated miRNAs studied by us, hsa-miR-92b-5p regulates coronin 1A expression under the effect of HIV-1 Tat. +transcription factor target 35415251 hsa-mir-22 Cryptorchidism 5p regulates SSCs' self-renewal by targeting EZH2, which indicated that miR +transcription factor target 35415251 hsa-mir-22 Infertility 5p regulates SSCs' self-renewal by targeting EZH2, which indicated that miR +other 35415250 hsa-mir-1283 Adenocarcinoma of Lung In conclusion, circ_0020123 interacts with miR-1283 as a ceRNA to regulate PDZD8 expression, thus promoting the proliferation and migration of LUAD cells. +circRNA target 35415249 hsa-mir-942 Pre-Eclampsia To sum up, our results revealed that circ_0085296 could inhibit trophoblast cells proliferation, migration, invasion, and angiogenesis by regulating miR5p/THBS2, confirming that circ_0085296 might be a potential therapeutic target for PE. +other 35415247 hsa-mir-340 Endometriosis 5p in endometriosis is unclarified. +genetics_knock down_suppress 35415236 hsa-mir-377 Carcinoma, Hepatocellular Moreover, overexpression of miR +lncRNA target 35415017 hsa-mir-145 Stomach Neoplasms We hypothesize that hsacirc_004413 makes gastric cancer cells resistant to 5-Fu mainly through adsorption of miR5p. +genetics_overexpression_promote 35414782 hsa-mir-148a Carcinoma, Hepatocellular We found that miR-148a-3p was downregulated in co-cultured HSCs and overexpression of miR-148a-3p in HSCs impaired the proliferation and invasiveness of HCC both in vitro and in vivo. +genetics_knock down_promote 35414500 hsa-mir-561 Carcinoma, Pancreatic Ductal CONCLUSION: The overexpression of miR +genetics_knock down_suppress 35414334 hsa-mir-1252 Uterine Cervical Neoplasms Rescue experiments found that miR5p overexpression or EIF4EBP2 knockdown could reverse the influence on CC cells caused by circ_0000190 overexpression. +lncRNA target 35414313 hsa-mir-139 Endometriosis Rescue experiments demonstrated that DHRS4-AS1 inhibited EC-ESC proliferation, migration, and invasion, but promoted apoptosis, by targeting miR +genetics_knock down_promote 35414011 hsa-mir-142 Cardiomyopathies 3p overexpression attenuated apoptosis and pyroptosis in cardiomyocytes, which was partly counteracted by ATXN1L overexpression. +transcription factor target 35413838 hsa-mir-489 Carcinoma, Non-Small-Cell Lung 3p promotes the malignant progression of NSCLC cells via targeting USP48, which might offer a new perspective into NSCLC treatment. +genetics_knock down_suppress 35413678 hsa-mir-24 Myocardial Reperfusion Injury CONCLUSION: Circ_0050908 knockdown protects cardiomyocytes against I/R injury by reducing apoptosis, inflammatory response, and oxidative stress through miR +genetics_overexpression_suppress 35413598 hsa-mir-338 Stomach Neoplasms CONCLUSION: The overexpression of circ_0051620 is found to be associated with progress and poor prognosis of GC, promoting the development and metastasis via sponging miR +virus_miRNA 35413475 kshv-mir-K12-1 Sarcoma, Kaposi Kaposi's sarcoma-associated herpes virus-derived microRNA K12-1 over-activates the PI3K/Akt pathway to facilitate cancer progression in HIV-related gastrointestinal Kaposi's sarcoma +lncRNA target 35413439 hsa-mir-215 Inflammation 5p might be novel potential treatment targets in bacterial infection-related myocardial damages. +genetics_overexpression_promote 35413430 hsa-mir-193a Ovarian Neoplasms Rescue experiments exhibited two results: miR-193a-5p hindered proliferation, migration and invasion of ovarian cancer cells, and this suppression was counteracted by overexpression of RAB11A and miR-193a-5p. +genetics_overexpression_suppress 35413218 hsa-mir-622 Precursor Cell Lymphoblastic Leukemia-Lymphoma MiR-622 restoration inhibited AML cell proliferation and induced cell apoptosis, while RAB10 overexpression abolished these effects. CONCLUSION: : Circ_KCNQ5 high expression was associated with childhood AML malignant development, and circ_KCNQ5 participated in AML progression by regulating the miR-622/RAB10 pathway. +genetics_knock down_promote 35413135 hsa-mir-182 Prostatic Neoplasms N6-methyladenosine (m6A) RNA immunoprecipitation assay (MeRIP) and co-immunoprecipitations assays were performed to verified that METTL3 upregulated the m6A level, interacted with microprocessor protein DGCR8, recognized the m6A modification of pre-miR-182 to regulate its maturation.METTL3 was highly expressed in prostate cancer, and knockdown of METTL3 significantly inhibited cell proliferation, migration, invasion and tumorigenesis, while overexpression of METTL3 promoted cell proliferation, migration, invasion and tumorigenesis in PCa. +lncRNA target 35412956 hsa-mir-642b Stomach Neoplasms Overall, miR-642b-3p acts as an oncomiR promoting tumor development in GC through suppressing CSMD1 expression and inactivating the Smad signaling pathway, which may enable the development of new therapeutic strategies for treatment of GC. +lncRNA target 35412955 hsa-mir-4731 Carcinoma, Renal Cell In conclusion, circEHD2 enhances RCC resistance to SU via acting as a miR +lncRNA target 35412954 hsa-mir-876 Triple Negative Breast Neoplasms Additionally, miR5p was demonstrated to be a target of LINC01315 and regulate the expression of GRK5, through which LINC01315 modulated the progression of TNBC. +lncRNA target 35412951 hsa-mir-378a Ovarian Neoplasms Furthermore, via inhibition of Wnt5a, miR-378a-3p alleviated DDP resistance in OC cells. +other 35412947 hsa-mir-129 Prostatic Neoplasms 5p. +genetics_overexpression_promote 35412941 hsa-mir-134 Leukemia, Myeloid, Acute Functionally, circ_0004277 overexpression or inhibition of miR +other 35412895 hsa-mir-126 Leukemia Thus, miR-126 down-regulation in proliferating AML blasts is downstream of FLT3-ITD-dependent miR-155 expression that initiates a complex circuit of concatenated regulatory feedback (i.e., miR-126/SPRED1, miR-155/human dead-box protein 3 [DDX3X]) and feed-forward (i.e., miR-155/SHIP1/AKT/miR-126) regulatory loops that eventually converge into an output signal for leukemic growth. +other 35412895 hsa-mir-126 Leukemia, Myeloid, Acute Thus, miR-126 down-regulation in proliferating AML blasts is downstream of FLT3-ITD-dependent miR-155 expression that initiates a complex circuit of concatenated regulatory feedback (i.e., miR-126/SPRED1, miR-155/human dead-box protein 3 [DDX3X]) and feed-forward (i.e., miR-155/SHIP1/AKT/miR-126) regulatory loops that eventually converge into an output signal for leukemic growth. +other 35412895 hsa-mir-155 Leukemia Thus, miR-126 down-regulation in proliferating AML blasts is downstream of FLT3-ITD-dependent miR-155 expression that initiates a complex circuit of concatenated regulatory feedback (i.e., miR-126/SPRED1, miR-155/human dead-box protein 3 [DDX3X]) and feed-forward (i.e., miR-155/SHIP1/AKT/miR-126) regulatory loops that eventually converge into an output signal for leukemic growth. +other 35412895 hsa-mir-155 Leukemia, Myeloid, Acute Thus, miR-126 down-regulation in proliferating AML blasts is downstream of FLT3-ITD-dependent miR-155 expression that initiates a complex circuit of concatenated regulatory feedback (i.e., miR-126/SPRED1, miR-155/human dead-box protein 3 [DDX3X]) and feed-forward (i.e., miR-155/SHIP1/AKT/miR-126) regulatory loops that eventually converge into an output signal for leukemic growth. +lncRNA target 35412486 hsa-mir-552 Inflammatory Bowel Diseases CONCLUSION: NORAD participates in TNF-alpha-induced FHC apoptosis, inflammation, and oxidative stress via the NF-kappaB signaling via the miR3p/MYD88 axis, offering new insights into the pathogenesis of UC. +genetics_knock down_promote 35412358 hsa-mir-143 Colorectal Neoplasms 3p inhibitor or overexpression rescues defects in cell invasion. +circulation_biomarker_diagnosis_ns 35412111 hsa-mir-193a Autism Spectrum Disorder The levels of EDNRA, SLC17A6, HTR3A, OSTC, TMEM165, PC-5p-139289_26, and hsa-miR-193a-5p were validated in at least 15 ASD and 15 TD individual serum samples, which were consistent with the results of transcriptome analysis. +other 35412062 hsa-mir-29 Postoperative Cognitive Complications 3p/CREB1/IL1RA axis. +lncRNA target 35411930 hsa-mir-497 Postoperative Cognitive Complications CONCLUSIONS: Induction of miR-497 was involved in isoflurane anesthesia-induced cognitive impairment and neuronal cell apoptosis by targeting PLD1. +other 35411833 hsa-mir-34a Carcinoma, Non-Small-Cell Lung Therefore, OIP5-AS1 was upregulated to enhance the expression of oncogenic PD-L1 by sponging miR-34a in NSCLC, leading to promoted NSCLC cell proliferation. Our study also demonstrated that OIP5-AS1 was upregulated while miR-34a was downregulated in NSCLC. +other 35411716 hsa-mir-1290 Esophageal Squamous Cell Carcinoma CONCLUSION: Our findings uncover an undescribed molecular mechanism, the circ_0001946/miR-1290/SOX6 ceRNA crosstalk, for the anti-ESCC activity of circ_0001946. +exosome 35411604 hsa-mir-184 Glioma On the other hand, miR-3184 in glioma-derived exosomes polarizes macrophages to an M2-like phenotype, which further aggravates tumour progression. +exosome 35411299 hsa-mir-10a Stomach Neoplasms Results: We identified that exosomal miR-10a-5p, miR-19b-3p, miR5p, and miR-18a-5p were significantly upregulated in GC patient's exosomes in contrast to HCs exosomes, Roc curve analysis indicated area under the ROC curve (AUC) of 0.801, 0.721, 0.780 and 0.736 respectively. +exosome 35411299 hsa-mir-18a Stomach Neoplasms Results: We identified that exosomal miR-10a-5p, miR-19b-3p, miR5p, and miR-18a-5p were significantly upregulated in GC patient's exosomes in contrast to HCs exosomes, Roc curve analysis indicated area under the ROC curve (AUC) of 0.801, 0.721, 0.780 and 0.736 respectively. +exosome 35411299 hsa-mir-215 Stomach Neoplasms Results: We identified that exosomal miR-10a-5p, miR-19b-3p, miR5p, and miR-18a-5p were significantly upregulated in GC patient's exosomes in contrast to HCs exosomes, Roc curve analysis indicated area under the ROC curve (AUC) of 0.801, 0.721, 0.780 and 0.736 respectively. +exosome 35411299 hsa-mir-19b Stomach Neoplasms Results: We identified that exosomal miR-10a-5p, miR-19b-3p, miR5p, and miR-18a-5p were significantly upregulated in GC patient's exosomes in contrast to HCs exosomes, Roc curve analysis indicated area under the ROC curve (AUC) of 0.801, 0.721, 0.780 and 0.736 respectively. +other 35411175 hsa-mir-770 Dmd-Associated Dilated Cardiomyopathy 3p, PIK3R1, DDIT4, and CXCR4 as hub genes in DCM. +other 35411175 hsa-mir-363 Dmd-Associated Dilated Cardiomyopathy 3p, PIK3R1, DDIT4, and CXCR4 as hub genes in DCM. +other 35411175 hsa-mir-551b Dmd-Associated Dilated Cardiomyopathy 3p, PIK3R1, DDIT4, and CXCR4 as hub genes in DCM. +lncRNA target 35410813 hsa-mir-570 Breast Neoplasms CONCLUSION: MALAT1 functions as a novel oncogenic lncRNA in regulating the progression and doxorubicin resistance of BC by targeting miR +circRNA target 35410505 hsa-mir-31 Spinal Cord Injuries Thus, our results suggested that in SCI pathogenesis, hsa_circ_0026646 correlates with PLXNB2 by targeting miR +lncRNA target 35410500 hsa-mir-497 Neurotoxicity Syndromes In conclusion, our findings indicated that SNHG12 might relieve BV-associated neurotoxicity by upregulating NLRX1 via miR +target gene 35410355 hsa-mir-146a Liver Neoplasms MicroRNA-146a promotes proliferation, migration, and invasion of HepG2 via regulating FLAP. +other 35410298 hsa-mir-33a Atrial Fibrillation Taking into consideration both the ceRNA theory and inference scores from the comparative toxicogenomics database (CTD) database, the ceRNA axis FAM201A-miR-33a-3p-RAC3 was identified as mostly relevant to AF susceptibility. +other 35409311 hsa-mir-20b Premature Birth 3p appeared just in PTB pregnancies. +other 35409311 hsa-mir-16 Premature Birth 3p, AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut off > 0.652) can predict preterm delivery before 37 weeks of gestation in early stages of gestation in 52.83% pregnancies at 10.0% FPR. +other 35409311 hsa-mir-24 Premature Birth 3p, AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut off > 0.652) can predict preterm delivery before 37 weeks of gestation in early stages of gestation in 52.83% pregnancies at 10.0% FPR. +other 35409311 hsa-mir-221 Premature Birth 3p appeared just in PTB pregnancies. +other 35409311 hsa-mir-92a Premature Birth 3p, AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut off > 0.652) can predict preterm delivery before 37 weeks of gestation in early stages of gestation in 52.83% pregnancies at 10.0% FPR. +other 35409311 hsa-mir-210 Premature Birth 3p was a common feature of PTB and PPROM pregnancies. +other 35409311 hsa-mir-145 Premature Birth 3p, AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut off > 0.652) can predict preterm delivery before 37 weeks of gestation in early stages of gestation in 52.83% pregnancies at 10.0% FPR. +other 35409311 hsa-mir-126 Premature Birth 3p appeared just in PTB pregnancies. +other 35409311 hsa-mir-26a Premature Birth 3p, AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut off > 0.652) can predict preterm delivery before 37 weeks of gestation in early stages of gestation in 52.83% pregnancies at 10.0% FPR. +other 35409311 hsa-mir-133a Premature Birth 3p, AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut off > 0.652) can predict preterm delivery before 37 weeks of gestation in early stages of gestation in 52.83% pregnancies at 10.0% FPR. +other 35409311 hsa-mir-342 Premature Birth 3p, AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut off > 0.652) can predict preterm delivery before 37 weeks of gestation in early stages of gestation in 52.83% pregnancies at 10.0% FPR. +other 35409311 hsa-mir-146a Premature Birth 3p, AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut off > 0.652) can predict preterm delivery before 37 weeks of gestation in early stages of gestation in 52.83% pregnancies at 10.0% FPR. +other 35409311 hsa-mir-155 Premature Birth 3p, AUC 0.812, p < 0.001, 70.75% sensitivity, 78.75% specificity, cut off > 0.652) can predict preterm delivery before 37 weeks of gestation in early stages of gestation in 52.83% pregnancies at 10.0% FPR. +other 35409278 hsa-mir-338 Hemorrhagic Fever with Renal Syndrome Decreased TA C-IV subunit expression in HFHS-S was reverted in HFHS-E, concomitantly with the downregulation of miR-338. +other 35409234 hsa-mir-483 Depressive Disorder, Major A total of 228 miRNAs were significantly correlated with depressive symptoms improvements after 2 weeks of SSRIs treatment, with miR-483.5p showing the most robust correlation. +genetics_GWAS 35409153 hsa-mir-499a Cardiomyopathy, Hypertrophic Circulating miR-499a-5p Is a Potential Biomarker of MYH7-Associated Hypertrophic Hypertrophic cardiomyopathy (HCM) is the most common inherited myocardial disease with significant genetic and phenotypic heterogeneity. +exosome 35409043 hsa-mir-130a Triple Negative Breast Neoplasms Hsa-miR3p was significantly upregulated, and hsa-miR-130a-3p was significantly downregulated in exosomes from breast cancer patients with cerebral metastases with AUC: 0.705 and 0.699, respectively. +exosome 35409043 hsa-mir-130a Breast Neoplasms Hsa-miR3p was significantly upregulated, and hsa-miR-130a-3p was significantly downregulated in exosomes from breast cancer patients with cerebral metastases with AUC: 0.705 and 0.699, respectively. +exosome 35409043 hsa-mir-576 Triple Negative Breast Neoplasms Hsa-miR3p was significantly upregulated, and hsa-miR-130a-3p was significantly downregulated in exosomes from breast cancer patients with cerebral metastases with AUC: 0.705 and 0.699, respectively. +exosome 35409043 hsa-mir-576 Breast Neoplasms Hsa-miR3p was significantly upregulated, and hsa-miR-130a-3p was significantly downregulated in exosomes from breast cancer patients with cerebral metastases with AUC: 0.705 and 0.699, respectively. +other 35409006 hsa-let-7c Myopia, High A miRNA-Array analysis revealed that let-7c was significantly up-regulated and miR-200a was significantly down-regulated in high myopic MH eyes compared to those in MH eyes. +other 35409006 hsa-mir-200a Myopia, High A miRNA-Array analysis revealed that let-7c was significantly up-regulated and miR-200a was significantly down-regulated in high myopic MH eyes compared to those in MH eyes. +lncRNA target 35408903 hsa-mir-326 Colorectal Neoplasms In terms of mechanism, kaempferol promotes the expression of microRNA-326 (miR-326) in colon cancer cells, and miR-326 could inhibit the process of glycolysis by directly targeting pyruvate kinase M2 isoform (PKM2) 3'-UTR (untranslated region) to inhibit the expression of PKM2 or indirectly block the alternative splicing factors of PKM mRNA, and then reverse the resistance of colorectal cancer cells to 5-Fu. +lncRNA target 35408829 hsa-mir-125b Leukemia miRNAs with the highest number of MTIs were miR-125b-5p, miR5p, miR-181a-5p and miR-19a-3p, while target genes with the highest number of MTIs were TP53, BCL2, KIT, ATM, RUNX1 and ABL1. +lncRNA target 35408829 hsa-mir-155 Leukemia miRNAs with the highest number of MTIs were miR-125b-5p, miR5p, miR-181a-5p and miR-19a-3p, while target genes with the highest number of MTIs were TP53, BCL2, KIT, ATM, RUNX1 and ABL1. +lncRNA target 35408691 hsa-mir-877 Pancreatic Carcinoma (4) Conclusions: our findings indicate that rutin plays an important role in anti-pancreatic cancer effects through a rutin-miR +lncRNA target 35406786 hsa-mir-338 Adenocarcinoma of Lung FAM111/ZWINT pathways as potential diagnostic biomarkers or therapeutic targets of LUAD. +circulation_biomarker_diagnosis_down 35406680 hsa-mir-146a Bronchiolitis Obliterans We observed a significant downregulation of circulating hsa-miR +circulation_biomarker_diagnosis_down 35406680 hsa-mir-1 Bronchiolitis Obliterans We observed a significant downregulation of circulating hsa-miR +circulation_biomarker_diagnosis_down 35406680 hsa-mir-155 Bronchiolitis Obliterans We observed a significant downregulation of circulating hsa-miR +lncRNA target 35406629 hsa-mir-29b-2 Colorectal Neoplasms Our findings suggest that, LOC550643-miR-29b5p axis was determined to participate in the growth and metastasis of colon cancer cells; this could serve as a useful molecular biomarker for cancer diagnosis and as a potential therapeutic target for CRC. +transcription factor target 35406534 hsa-mir-214 Sarcoma, Ewing 3p is constitutively repressed by both EWS-FLI1 and CD99 because it acts as an oncosuppressor limiting the dissemination of EWS cells. +lncRNA target 35406446 hsa-mir-26b Leukemia, Lymphocytic, Chronic, B-Cell Specifically, up-regulation of miR-26b-5p in CLL cells blocks TGF-beta/SMAD pathway by down-modulation of SMAD-4, resulting in lower expression of p21(-Cip1) kinase inhibitor and higher expression of c-Myc oncogene. +lncRNA target 35406401 hsa-mir-139 Carcinoma, Hepatocellular CONCLUSION: We demonstrate for the first time that 5-Aza can impair HCC development via upregulation of miR5p, which in turn impairs the ROCK2/cyclin D1/E2F1/cyclin B1 pro-proliferative pathway and the ROCK2/MMP-2 pro-migratory pathway. +target gene 35406397 hsa-mir-199a Prostatic Neoplasms Regulation of Let-7a-5p and miR-199a-5p Expression by Akt1 Modulates Prostate Cancer Epithelial-to-Mesenchymal Transition via the Transforming Growth Factor-β Pathway. +target gene 35406397 hsa-let-7a Prostatic Neoplasms Regulation of Let-7a-5p and miR-199a-5p Expression by Akt1 Modulates Prostate Cancer Epithelial-to-Mesenchymal Transition via the Transforming Growth Factor-β Pathway. +other 35406086 hsa-mir-551a Carcinoma The hsa-miR-551a upregulation, which has been linked to a reduced cell migration and invasion in several carcinomas, suggests a novel mechanism of walnuts in cancer risk. +circulation_biomarker_diagnosis_ns 35405462 hsa-mir-21 Lung Neoplasms In addition, the feasibility is confirmed by performing the detection of miRNA-21 extracted from non-small cell lung cancer (NSCLC) A549 cells, and a good recovery is achieved in complex human serum sample. +lncRNA target 35405317 hsa-mir-21 Neuroblastoma RESULTS: Downregulated expression of FOXO3a was observed in neuroblastoma cells, with a negative correlation between FOXO3a and miR-21 expression. CONCLUSIONS: In conclusion, FOXO3a may inhibit the progression of neuroblastoma by suppressing the miR-21 expression and facilitating SPRY2-dependent ERK pathway inactivation. +lncRNA target 35404759 hsa-mir-7-2 Endometrial Neoplasms 2-3p/DCLK1 axis contributes to the proliferation and metastasis of endometrial cancer cells via the PI3K/Akt/NF-kappaB pathway. +lncRNA target 35404727 hsa-mir-15a Gallbladder Neoplasms AFAP1-AS1 may regulate GBC cell proliferation and apoptosis via has-miR-15a-5p to mediate bcl-2 expression. +lncRNA target 35404476 hsa-mir-155 Asthma However, no specific cell-intrinsic role has yet been elucidated for miR-155 in T cells in the course of Th2-eosinophilic and Th17-neutrophilic airway inflammation using actual in vivo asthma models. Conclusively, our data revealed that miR-155 could promote Th2 and Th17-mediated airway inflammation via the regulation of several different target genes, depending on the context of asthmatic diseases. +other 35404333 hsa-mir-1 Inflammatory Bowel Diseases We confirmed miR-31, -106a, and -135b to be significantly deregulated between normal mucosa and dysplasia, as well as across the UC-associated CRC sequence (all P < 0.01). +circulation_biomarker_diagnosis_ns 35404278 hsa-mir-34c hypoglycemic encephalopathy The serum levels of miR-34c were increased in patients with DE comparing with normal controls. +circulation_biomarker_diagnosis_ns 35404278 hsa-mir-34c Diabetic Neuropathies The serum levels of miR-34c were increased in patients with DE comparing with normal controls. +genetics_knock down_suppress 35404176 hsa-mir-16 Rhinitis, Allergic 5p inhibitor could reverse ANRIL knockdown-induced downregulation of autophagy-related proteins and epithelial barrier dysfunction. +genetics_overexpression_promote 35403775 hsa-mir-107 Squamous Cell Carcinoma of Head and Neck miR-107 directly targeted the 3' untranslated region of FZD4, and FZD4 overexpression largely reversed the anti-tumor effects of circ_0001971 in OSCC cells. +other 35402824 hsa-mir-214 Anemia, Aplastic Abnormal miR-214/A20 expression might play a role in T cell activation in patients with aplastic anemia. +other 35402661 hsa-mir-20a Heart Failure RESULTS: Expression of miRNA-320a was up-regulated while RUNX2 expression was down-regulated in TIONFH than Normal control. +other 35402587 hsa-mir-206a Glioma Validated by Chinese Glioma Genome Atlas and our LGG patients of gene expression and survival, and the colorectal neoplasia differentially expressed (CRNDE), HOXA transcript antisense RNA, myeloid-specific 1 (HOTAIRM1)/miRNA-206a/hepatocyte nuclear factor 4 (HNF4G) axis was determined. +exosome 35402583 hsa-mir-432 late onset Parkinson's disease This study was designed to investigate if there is a correlation between PDE exosomal miRNA (miR +circulation_biomarker_diagnosis_up 35402577 hsa-mir-21 Crohn Disease RESULTS: Our data revealed that the circulating exosomes of patients with CD have a remarkable effect on the proliferation and migration of human umbilical vein endothelial cells (HUVECs), and that exosomal miR-21 levels were highly elevated in exosomes derived from the plasma of CD patients. +other 35402537 hsa-mir-16 Ventricular Remodeling Using RT-qPCR we confirmed a significant increase in miR-16, miR5p, and miR-29a-3p, suggested to modulate the expression of different cytokines, 6 h post-PPCI in LVAR patients. +other 35402537 hsa-mir-21 Ventricular Remodeling Using RT-qPCR we confirmed a significant increase in miR-16, miR5p, and miR-29a-3p, suggested to modulate the expression of different cytokines, 6 h post-PPCI in LVAR patients. +other 35402537 hsa-mir-29a Ventricular Remodeling Using RT-qPCR we confirmed a significant increase in miR-16, miR5p, and miR-29a-3p, suggested to modulate the expression of different cytokines, 6 h post-PPCI in LVAR patients. +other 35402517 hsa-mir-141 Carcinoma, Renal Cell In summary, our results demonstrate the oncogenic role of FAM13A-AS1 in RCC and suggest that it promotes tumorigenesis by upregulating the expression of NEK6 by competitively binding to miR3p. +other 35402226 hsa-mir-216 Glioma In summary, our study shows that the HOXC-AS3/miR-216/F11R axis plays an important role in the malignant progression of glioma, and may provide new ideas for the treatment of glioma. +lncRNA target 35402187 hsa-mir-150 Nasopharyngeal Carcinoma CONCLUSIONS: The progression of NPC tumors is facilitated by lncRNA IGBP1-AS1 via miR5p and regulates ZEB1 expression. +lncRNA target 35402183 hsa-mir-595 Carcinoma, Non-Small-Cell Lung Additionally, we demonstrated that circPTN upregulated LYRM5 expression by sponging miR-595, which promoted NSCLC angiogenesis in NSCLC. CONCLUSIONS: We found that circPTN serves as a competing endogenous ribonucleic acid that promotes angiogenesis via the miR-595/LYRM5 signaling pathway in NSCLC. +target gene 35402178 hsa-mir-144 Carcinoma, Non-Small-Cell Lung LncRNA B4GALT1-AS1 promotes non-small cell lung cancer cell growth via increasing ZEB1 level by sponging miR-144-3p. +transcription factor target 35402074 hsa-mir-130b Diabetic Nephropathies Additionally, the inhibition of miR-130b-3p with an antagomir in vivo effectively enhanced glomerular podocyte injury and mitotic dysfunction, eventually exacerbating proteinuria. +lncRNA target 35402073 hsa-mir-25 Femur Head Necrosis Results showed that circHGF suppressed the proliferation and osteogenic differentiation of BMSCs in ONFH by targeting miR3p/SMAD7 axis. +circulation_biomarker_diagnosis_ns 35401927 hsa-mir-206 Cardiomyopathy, Hypertrophic ACTB, miR-206, circFN1, and ADAMTS9-AS1 expression in peripheral blood samples from HCM patients and normal healthy controls were detected using RT-qPCR. +other 35401881 hsa-mir-4713 Pediatric Obesity The expression of GATA3, miR-452, and miR-4713 was also significantly lower in the obesity and the obesity with fracture groups when compared to the NC group. Therefore, NPY1R, TCF4, HEY1, GATA3, miR-452, and miR-4713 may be risk factors for fracture in obese children. +other 35401881 hsa-mir-452 Pediatric Obesity The expression of GATA3, miR-452, and miR-4713 was also significantly lower in the obesity and the obesity with fracture groups when compared to the NC group. Therefore, NPY1R, TCF4, HEY1, GATA3, miR-452, and miR-4713 may be risk factors for fracture in obese children. +genetics_overexpression_promote 35401845 hsa-mir-525 Colorectal Neoplasms 5p could be sponged by circ_0000423, and its overexpression also abolished the regulation of circ_0000423 on the progression of SEV-treated CRC cells. +lncRNA target 35401844 hsa-mir-625 Carcinoma, Hepatocellular CONCLUSION: LINC00852 regulates HCC cell activities via the miR-625/E2F1 axis. +other 35401746 hsa-mir-4713 Squamous Cell Carcinoma of Head and Neck Bioinformatics analysis revealed that miR3p is a key miRNA of EPHX3 in HNSCC. +circulation_biomarker_prognosis_up 35401744 hsa-mir-13 Leukemia, Promyelocytic, Acute CONCLUSION: Serum miR +circulation_biomarker_prognosis_up 35401744 hsa-mir-126 Leukemia, Promyelocytic, Acute CONCLUSION: Serum miR +other 35401696 hsa-mir-376c Esophageal Neoplasms 3p/YTHDF1 axis, respectively. +other 35401696 hsa-mir-655 Esophageal Neoplasms 3p/YTHDF1 axis, respectively. +other 35401675 hsa-mir-16 Amelogenesis Imperfecta Thus, our study shows that miR5p and miR-27b-3p are candidate pathogenic miRNAs for amelogenesis imperfecta. +other 35401675 hsa-mir-27b Amelogenesis Imperfecta Thus, our study shows that miR5p and miR-27b-3p are candidate pathogenic miRNAs for amelogenesis imperfecta. +other 35401659 hsa-mir-125b Ischemic Stroke We used the criterion AUC >0.8, to screen a 3-gene signature (FBL, RPS3, and RPS15) and the aberrantly expressed miRNAs (hsa-miR-125a-5p, hsa-miR-125b-5p, hsa-miR-148b-3p, and hsa-miR3p) in AIS, which were verified by a method of quantitative PCR (qPCR) in HT22 cells. +other 35401659 hsa-mir-148b Ischemic Stroke We used the criterion AUC >0.8, to screen a 3-gene signature (FBL, RPS3, and RPS15) and the aberrantly expressed miRNAs (hsa-miR-125a-5p, hsa-miR-125b-5p, hsa-miR-148b-3p, and hsa-miR3p) in AIS, which were verified by a method of quantitative PCR (qPCR) in HT22 cells. +other 35401659 hsa-mir-125a Ischemic Stroke We used the criterion AUC >0.8, to screen a 3-gene signature (FBL, RPS3, and RPS15) and the aberrantly expressed miRNAs (hsa-miR-125a-5p, hsa-miR-125b-5p, hsa-miR-148b-3p, and hsa-miR3p) in AIS, which were verified by a method of quantitative PCR (qPCR) in HT22 cells. +transcription factor target 35401251 hsa-mir-124 Morphine Dependence CONCLUSION: MiR-124 and its target protein IQGAP1 are involved in the regulation of addiction and cognitive function in patients with morphine dependence. +other 35401251 hsa-mir-124 Cognition Disorders The level of miR-124 was an independent factor influencing the severity of cognitive impairment in patients with morphine dependence. +other 35401251 hsa-mir-124 Osteoarthritis MiR-124, IQGAP1, the average intake last year were related to OASI scores.MiR-124, IQGAP1, PHQ-9 were associated with MOCA scores. +epigenetics 35401185 hsa-mir-27 lung squamous cell carcinoma In addition of inhibiting activation of the Notch pathway by repressing methylation of the miR +exosome 35401112 hsa-let-7a Spinal Cord Injuries Further study found that let-7a-5p exerted a similar biological effect as MSC-EVs in regulating the differentiation of NSCs and leading to neurological improvement in SCI rats. In conclusion, MSC-EV-secreted let-7a-5p promoted the regrowth of neurons and improved neurological recovery in SCI rats by targeting the HMGA2/SMAD2 axis. +circulation_biomarker_diagnosis_up 35400999 hsa-mir-126 Myocardial Infarction We demonstrated that exosomes from the peripheral serum of AMI patients promote angiogenesis via the miR +other 35400282 hsa-mir-205 Colorectal Neoplasms This study demonstrated that the circ_0007331/miR5p/HMGA2 axis promotes CRC development. +genetics_overexpression_promote 35400275 hsa-mir-184 Carcinoma, Hepatocellular Mechanistically, miR-184 could be sponged by circITCH, and its overexpression could mitigate the suppressive effects of circITCH overexpression on HCC progression. Our findings reveal that circITCH served as a repressor to restrain HCC malignancy via miR-184. +circRNA target 35400271 hsa-mir-421 Carcinoma, Hepatocellular Silencing circSEC24A mitigated the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of HCC cells, which was abrogated by downregulation of miR-421. circSEC24A interference suppressed HCC cell EMT by sponging miR-421, further regulating MMP3, and inhibiting tumor growth in vivo. +genetics_overexpression_promote 35399733 hsa-mir-188 Pancreatic Carcinoma Besides, overexpression of miR +genetics_knock down_promote 35399726 hsa-mir-454 Wilms Tumor 3p was identified as the reason of WTX loss in HCC. +genetics_knock down_promote 35399726 hsa-mir-454 Carcinoma, Hepatocellular 3p was identified as the reason of WTX loss in HCC. +target gene 35399723 hsa-mir-216a Uterine Cervical Neoplasms LncRNA HCP5 enhances the proliferation and migration of cervical cancer via miR-216a-5p/CDC42 axis. +other 35399713 hsa-mir-338 Osteosarcoma KLF9 regulates miR-338-3p/NRCAM axis to block the progression of osteosarcoma cells. +other 35399708 hsa-mir-339 Adenocarcinoma of Lung Taken together, our results uncovered a Uc.339/miR-339/SLC7A11 axis that leads to defects in the ferroptosis in lung cancer, and constitutes a potential mechanism that drives the metastasis of lung adenocarcinoma. +exosome 35399607 hsa-mir-760 Breast Neoplasms Next, ARF6 was confirmed as a target gene of miR-760 in exosomes derived from CCL18-stimulated high metastatic BC cells. Together, our results support that exosomal miR-760 secreted by CCL18-stimulated high metastatic BC cells promoted the malignant behaviors in low metastatic BC cells by up-regulating the ARF6-mediated Src/PI3K/Akt signaling pathway. +other 35399604 hsa-let-7b Carcinoma, Ovarian Epithelial Decrease in Let7b miRNA levels in clinical ovarian cancer has been associated with chemoresistance, increased proliferation, invasion, and relapse in EOC. We demonstrate that a therapeutic combination of Let7b miRNA and PTX leads to significant improvement in anti-tumor efficacy in the relapsed model of EOC. +lncRNA target 35399564 hsa-mir-1184 Adenocarcinoma of Lung Furthermore, circP4HB protects LUAD from ferroptosis via modulation of the miR-1184/SLC7A11 axis. +genetics_overexpression_promote 35399330 hsa-mir-217 Breast Neoplasms 5p overexpression may inhibit cell migration, invasion, the EMT and NF-kappaB signaling pathway in BC via targeting of MTDH. +other 35399328 hsa-mir-1 Colorectal Neoplasms 5p-DMD axis may serve as a novel biomarker in predicting the development of SEOCRC, and DMD can be used as a promising biomarker for the prognosis of SEOCRC. +genetics_overexpression_promote 35399229 hsa-mir-16 Carcinoma, Non-Small-Cell Lung 5p inhibitor or BCLCL2-overexpression reversed LINC00152 siRNA-induced NSCLC cell growth inhibition. +circulation_biomarker_diagnosis_up 35399150 hsa-mir-21 Breast Neoplasms Regarding the early stages of BC, the median levels of the fold change of serum miR21 and miR10b were statistically significantly higher in patients with BC (stages I and IIa) than in the control group (P < 0.001). +circulation_biomarker_diagnosis_up 35399150 hsa-mir-10b Breast Neoplasms Regarding the early stages of BC, the median levels of the fold change of serum miR21 and miR10b were statistically significantly higher in patients with BC (stages I and IIa) than in the control group (P < 0.001). +lncRNA target 35399101 hsa-mir-145 Endometriosis Furthermore, erastin-induced ferroptosis shrunk endometriotic lesions via the MALAT1/miR5p/MUC1 axis in vivo. +other 35399100 hsa-mir-140 Osteoarthritis CONCLUSION: To sum up, this study showed that PVT1 promoted expressions of ADAMTS-5 and MMP-13 as a competing endogenous RNA (ceRNA) of miR-140 in OA, which eventually led to aggravation of ECM degradation, thus providing a new and promising strategy for the treatment of OA. +lncRNA target 35399076 hsa-mir-195 Adenocarcinoma of Lung CONCLUSION: Silencing LINC00511 promotes GCNT3 expression by inhibiting miR +lncRNA target 35399004 hsa-mir-183 Nonsyndromic Deafness The reported NSHL target genes (2009-2020) have been studied by analyzing different biochemical and signaling pathways, interpretation of their functional association network, and discovery of important regulatory interactions with three previously established miRNAs in the human inner ear as well as in NSHL such as miR-183, miR-182, and miR-96. +lncRNA target 35399004 hsa-mir-182 Nonsyndromic Deafness The reported NSHL target genes (2009-2020) have been studied by analyzing different biochemical and signaling pathways, interpretation of their functional association network, and discovery of important regulatory interactions with three previously established miRNAs in the human inner ear as well as in NSHL such as miR-183, miR-182, and miR-96. +lncRNA target 35399004 hsa-mir-96 Nonsyndromic Deafness The reported NSHL target genes (2009-2020) have been studied by analyzing different biochemical and signaling pathways, interpretation of their functional association network, and discovery of important regulatory interactions with three previously established miRNAs in the human inner ear as well as in NSHL such as miR-183, miR-182, and miR-96. +genetics_knock down_suppress 35398813 hsa-mir-145 Biliary Atresia This work validated that ligustrazine-regulated miR-145 mediated TGF-beta/Smad signaling to inhibit the progression of liver fibrosis in a biliary atresia rat model and provided a new therapeutic strategy for liver fibrosis. In addition, overexpression and knockdown of miR-145 confirmed that miR-145 is involved in the ligustrazine inhibition of liver fibrosis through the TGF-beta/SMAD signaling pathway. +genetics_knock down_suppress 35398813 hsa-mir-145 Liver Cirrhosis This work validated that ligustrazine-regulated miR-145 mediated TGF-beta/Smad signaling to inhibit the progression of liver fibrosis in a biliary atresia rat model and provided a new therapeutic strategy for liver fibrosis. In addition, overexpression and knockdown of miR-145 confirmed that miR-145 is involved in the ligustrazine inhibition of liver fibrosis through the TGF-beta/SMAD signaling pathway. +lncRNA target 35398468 hsa-mir-34a Prostatic Neoplasms In the present study, we evaluated the association between the expression levels of HPV genes with the expression of selected cellular miRNAs (miR-19a, miR-21, miR-23b, miR-34a, miR5p, and miR-155) and their targets genes (P53, Rb, c-Myc, TIMP-1, MMP-2, MMP-9, PDCD4, Bcl-2, and Survivin) in PCa tissue samples. +lncRNA target 35398468 hsa-mir-155 Prostatic Neoplasms In the present study, we evaluated the association between the expression levels of HPV genes with the expression of selected cellular miRNAs (miR-19a, miR-21, miR-23b, miR-34a, miR5p, and miR-155) and their targets genes (P53, Rb, c-Myc, TIMP-1, MMP-2, MMP-9, PDCD4, Bcl-2, and Survivin) in PCa tissue samples. +lncRNA target 35398468 hsa-mir-21 Prostatic Neoplasms In the present study, we evaluated the association between the expression levels of HPV genes with the expression of selected cellular miRNAs (miR-19a, miR-21, miR-23b, miR-34a, miR5p, and miR-155) and their targets genes (P53, Rb, c-Myc, TIMP-1, MMP-2, MMP-9, PDCD4, Bcl-2, and Survivin) in PCa tissue samples. +lncRNA target 35398468 hsa-mir-150 Prostatic Neoplasms In the present study, we evaluated the association between the expression levels of HPV genes with the expression of selected cellular miRNAs (miR-19a, miR-21, miR-23b, miR-34a, miR5p, and miR-155) and their targets genes (P53, Rb, c-Myc, TIMP-1, MMP-2, MMP-9, PDCD4, Bcl-2, and Survivin) in PCa tissue samples. +lncRNA target 35398468 hsa-mir-19a Prostatic Neoplasms 5p, and miR-155) and their targets genes (P53, Rb, c-Myc, TIMP-1, MMP-2, MMP-9, PDCD4, Bcl-2, and Survivin) in PCa tissue samples. +lncRNA target 35398468 hsa-mir-23b Prostatic Neoplasms 5p, and miR-155) and their targets genes (P53, Rb, c-Myc, TIMP-1, MMP-2, MMP-9, PDCD4, Bcl-2, and Survivin) in PCa tissue samples. +transcription factor target 35398394 hsa-mir-125a Diabetic Neuropathies Non-DN patients had significantly lower expression levels of miR-125a-5p, SEMA4D, ATG14, and ATG16L1 compared to the HC. Dysregulated expression of SEMA4C, PLXNB2, and ATG16L1, targeted by miR-19b-3p and miR-125a-5p, showed that they probably play a role in the DN development. +transcription factor target 35398208 hsa-mir-29a Carcinoma, Adenoid Cystic, Lacrimal Gland Current studies have identified differentially expressed miRNAs associated with LACCs of variable proliferation ability, and found that AKT2 is a direct target gene of miR-29a-3p, which will contribute to target gene therapy in patients with high proliferation LACC in the future. +lncRNA target 35398178 hsa-mir-2113 Glioblastoma To conclude, circPOLR2A enhanced the transcription of SOX9 through miR-2113/POU3F2 axis, thus exacerbating GBM cells growth. +lncRNA target 35398161 hsa-mir-221 Parkinson Disease In conclusion, HOTAIR attenuated the injury of SH-SY5Y cells induced by MPP(+) via miR +genetics_overexpression_promote 35397570 hsa-mir-143 Diabetes Mellitus, Type 2 While miR-143 was overexpressed in the SAT of obese and morbidly obese individuals compared to the normal-weight group, the pairwise comparison showed no significant difference in the miR-34a expression of SAT between the four BMI groups (P>0.01). +genetics_overexpression_promote 35397570 hsa-mir-34a Diabetes Mellitus, Type 2 While miR-143 was overexpressed in the SAT of obese and morbidly obese individuals compared to the normal-weight group, the pairwise comparison showed no significant difference in the miR-34a expression of SAT between the four BMI groups (P>0.01). A negative association was observed between the VAT PPARgamma expression and miR-34a expression in obese cases (beta = - 0.594, P=0.039). +lncRNA target 35397427 hsa-mir-142 Obesity Moreover, EXO-Lenti-circRNA_0075932 shRNA significantly restored burn-induced dysregulation of circRNA_0075932, miR-142, miR-495, NLRP3, PUM2, AuroraB, Ika, NF-kB, TNF-alpha, IL-1beta, and MCP-1 in obese rats. +lncRNA target 35397427 hsa-mir-495 Burns Moreover, EXO-Lenti-circRNA_0075932 shRNA significantly restored burn-induced dysregulation of circRNA_0075932, miR-142, miR-495, NLRP3, PUM2, AuroraB, Ika, NF-kB, TNF-alpha, IL-1beta, and MCP-1 in obese rats. +lncRNA target 35397427 hsa-mir-495 Obesity Moreover, EXO-Lenti-circRNA_0075932 shRNA significantly restored burn-induced dysregulation of circRNA_0075932, miR-142, miR-495, NLRP3, PUM2, AuroraB, Ika, NF-kB, TNF-alpha, IL-1beta, and MCP-1 in obese rats. +lncRNA target 35397427 hsa-mir-142 Burns Moreover, EXO-Lenti-circRNA_0075932 shRNA significantly restored burn-induced dysregulation of circRNA_0075932, miR-142, miR-495, NLRP3, PUM2, AuroraB, Ika, NF-kB, TNF-alpha, IL-1beta, and MCP-1 in obese rats. +transcription factor target 35397366 hsa-mir-636 Osteoporosis CONCLUSIONS: In summary, this paper proposed that IRF4/miR-636/DOCK9 may be considered as targets for the treatment of osteoporosis (OP). +transcription factor target 35397366 hsa-mir-636 Osteoporosis-pseudoglioma syndrome CONCLUSIONS: In summary, this paper proposed that IRF4/miR-636/DOCK9 may be considered as targets for the treatment of osteoporosis (OP). +genetics_overexpression_promote 35397087 hsa-mir-211 Squamous Cell Carcinoma of Head and Neck 3p overexpression (OE) group was significantly higher than negative control (NC) group treated with paclitaxel, suggesting miR +exosome 35397056 hsa-mir-148a Atrial Fibrillation In our study, exosomes derived from BMSCs inhibited the development of AF, and miR-148a acted a vital role in this segment. +genetics_knock down_promote 35397054 hsa-mir-613 Carcinoma, Non-Small-Cell Lung The loss-of-functional experiments suggested that knockdown of circFAM126A suppressed proliferation, migration and invasion, as well as caused apoptosis and cell cycle arrest in NSCLC cells, which was abolished by silencing of miR-613. +circRNA target 35397013 hsa-mir-548b Colorectal Neoplasms has_circ_0001944 downregulation can slow the progression of CRC partly by targeting miR-548b-3p. +lncRNA target 35396910 hsa-mir-98 Asthma In conclusion, ANRIL indirectly up-regulates CCND1 expression by targeting miR5p to promote ASMC proliferation, migration and ECM deposition, thus facilitating the pathogenesis of asthma. +exosome 35396771 hsa-mir-24 Carcinoma, Hepatocellular Collectively, we revealed that exosomal circGSE1 derived from hepatocellular carcinoma (HCC) cells promotes the progression of HCC by inducing Tregs expansion via regulating the miR5p/TGFBR1/Smad3 axis. +circRNA target 35396749 hsa-mir-486 Carcinoma, Non-Small-Cell Lung CONCLUSION: Circ_0011298 elevated Taxol resistance of NSCLC by sponging miR3p and upregulating CRABP2, providing a possible circRNA-targeted therapy for NSCLC. +genetics_knock down_suppress 35396504 hsa-mir-140 Urinary Bladder Neoplasms Knockdown of hsa_circRNA_0088036 inhibited the proliferation, migration, and metastasis of BCa cells via miR3p/FOXQ1 signaling, suggesting that hsa_circRNA_0088036 is a potential biomarker and therapeutic target for BCa. +circulation_biomarker_diagnosis_up 35395980 hsa-mir-424 Multiple Myeloma CONCLUSION: The serum levels of miR-424 and miR-765 in MM patients are significantly increased in the pattern increasing with the progression of MM stage. +circulation_biomarker_diagnosis_up 35395980 hsa-mir-765 Multiple Myeloma CONCLUSION: The serum levels of miR-424 and miR-765 in MM patients are significantly increased in the pattern increasing with the progression of MM stage. +other 35395974 hsa-mir-211 Acute Lymphoblastic Leukemia, T-Cell CONCLUSION: The expressions of miR-211, miR-155, and C-myc are up-regulated in T-ALL patients, closely related to prognosis, and linearly positively correlated with disease risk. +other 35395974 hsa-mir-155 Acute Lymphoblastic Leukemia, T-Cell CONCLUSION: The expressions of miR-211, miR-155, and C-myc are up-regulated in T-ALL patients, closely related to prognosis, and linearly positively correlated with disease risk. +lncRNA target 35395973 hsa-mir-155 Acute Lymphoblastic Leukemia, B-Cell RESULTS: Compared with normal tissues and cells, the expression level of miR-155 in B-ALL bone marrow tissue/cell line was increased (P<0.05); Compared with drug sensitive B-ALL tissues/cell lines, the expression level of miR-155 in drug resistant B-ALL tissues and cell lines was increased (P<0.05); Inhibition of miR-155 expression decreased the proliferation of REH/Ara-C cells (P<0.05), promoted apoptosis (P<0.05), enhanced the cytotoxicity of Ara-C (P<0.05), and inhibited Wnt/-Catenin signaling pathway related protein and MDR1 gene expression (P<0.05), which could be reversed by activating Wnt expression (P<0.05). +other 35395969 hsa-mir-217 Leukemia OBJECTIVE: To explore the effect of carvacrol on the biological behavior of leukemia cells and its regulation to circ-0008717/miR-217 molecular axis. CONCLUSION: Carvacrol can promote the expression of miR-217 by down-regulating the expression of circ-0008717, thereby reducing the proliferation and cloning ability of leukemia cells and promoting cell apoptosis. +lncRNA target 35395756 hsa-mir-30 Urinary Bladder Neoplasms Expression profiles of miR-330 targets in BC cells were assessed via western blotting. +lncRNA target 35395550 hsa-mir-214 Leukemia, Myeloid, Acute This study showed that hsa-miR3p-regulates aberrant lipolysis by promoting ATGL expression, which causes AML progression through the PPARalpha pathway. +circulation_biomarker_diagnosis_ns 35395459 hsa-mir-223 Inflammatory Bowel Diseases Herein, we established a fluorescent probe for ulcerative colitis (UC) activity-associated two serum biomarkers (miR-23a and miR-223) simultaneous detection, which used multi-color fluorescent DNA-stabilized silver nanoclusters (DNA-AgNC) illuminated by a close guanine (G)-rich sequence as a signal transducer and two split DNA probes as recognition units. +circulation_biomarker_diagnosis_ns 35395459 hsa-mir-23a Inflammatory Bowel Diseases Herein, we established a fluorescent probe for ulcerative colitis (UC) activity-associated two serum biomarkers (miR-23a and miR-223) simultaneous detection, which used multi-color fluorescent DNA-stabilized silver nanoclusters (DNA-AgNC) illuminated by a close guanine (G)-rich sequence as a signal transducer and two split DNA probes as recognition units. +genetics_overexpression_promote 35395444 hsa-mir-432 Stomach Neoplasms 5p overexpression counteracted the promoting effect of circ_0075825 on the malignancy of GC cells. +exosome 35394683 hsa-mir-184 Stomach Neoplasms Exosome miR-3184-5p inhibits gastric cancer growth by targeting XBP1 to regulate the AKT, STAT3, and IRE1 signalling pathways. +genetics_overexpression_promote 35394639 hsa-mir-320d Colorectal Neoplasms Interference with miR-320d or overexpression of c-Myc reversed the increased chemotherapeutic sensitivity of CRC-SCs induced by synergistic therapy with 5-FU and MR. In conclusion, the combined chemotherapy with MR can enhance the chemotherapeutic sensitivity of CRC-SCs by up-regulation of miR-320d to inhibit c-Myc expression, which lays a molecular basis for MR regulation of chemotherapeutic sensitivity of CRC-SCs. +genetics_knock down_suppress 35394558 hsa-mir-638 Glioma SZRD1 was a target of miR-318, and its overexpression overturned the inhibition effect of miR-638 mimic on glioma progression and angiogenesis. +lncRNA target 35394175 hsa-mir-1229 Breast Neoplasms 3p, and it inhibited tumor growth of BC in vivo by mediating the miR +other 35393569 hsa-mir-122 Rift Valley Fever To enhance specificity of NSs for use in hepatocellular carcinoma, we incorporated four miR-122 binding sites in the 3' untranslated region (UTR) of the NSs mRNA to achieve cell type specific expression. +other 35393513 hsa-mir-16 Urinary Bladder Neoplasms 3p, and let-7b-5p) which might be potentially associated with BC and could be a potential biomarker. +other 35393513 hsa-mir-335 Urinary Bladder Neoplasms 3p, and let-7b-5p) which might be potentially associated with BC and could be a potential biomarker. +other 35393513 hsa-mir-124 Urinary Bladder Neoplasms 3p, and let-7b-5p) which might be potentially associated with BC and could be a potential biomarker. +other 35393513 hsa-let-7b Urinary Bladder Neoplasms 3p, and let-7b-5p) which might be potentially associated with BC and could be a potential biomarker. +circulation_biomarker_diagnosis_ns 35393236 hsa-mir-206 Muscular Dystrophies 3p and miR-206 are promising serum-based biomarkers for Facioscapulohumeral Muscular Dystrophy type 1, miR +circulation_biomarker_diagnosis_ns 35393236 hsa-mir-363 Muscular Dystrophies 3p and miR-206 are promising serum-based biomarkers for Facioscapulohumeral Muscular Dystrophy type 1, miR +circulation_biomarker_diagnosis_ns 35393236 hsa-mir-223 Muscular Dystrophies 3p and miR-206 are promising serum-based biomarkers for Facioscapulohumeral Muscular Dystrophy type 1, miR +circulation_biomarker_diagnosis_ns 35393236 hsa-mir-143 Muscular Dystrophies 3p and miR-206 are promising serum-based biomarkers for Facioscapulohumeral Muscular Dystrophy type 1, miR +circulation_biomarker_diagnosis_ns 35393236 hsa-mir-25 Muscular Dystrophies 3p and miR-206 are promising serum-based biomarkers for Facioscapulohumeral Muscular Dystrophy type 1, miR +circulation_biomarker_diagnosis_up 35392987 hsa-mir-506 Diabetic Nephropathies 3p was downregulated in the serum of DN patients and HG-induced HK-2 cells. +exosome 35392967 hsa-mir-466f Fibrosis, Renal CONCLUSIONS: Our findings indicated that exosomal miR-466f-3p derived from mMSCs may possess anti-fibrotic properties and prevent radiation-induced EMT through inhibition of AKT/GSK3beta via c-MET, providing a promising therapeutic modality for radiation-induced lung fibrosis. +circulation_biomarker_diagnosis_up 35392782 hsa-mir-140 Pneumonia RESULTS: LncRNA H19 and TLR4 were up-regulated, while miR5p was downregulated in peripheral blood of patients with pneumonia and LPS-treated WI-38 cells compared with their controls. +lncRNA target 35392747 hsa-mir-214 Cataract CONCLUSION: Circ_0060640 is a novel cataract-related gene and its silencing could block TGF-beta2-evoked hLECs proliferation, motility and EMT in vitro via targeting miR3p-COL1A2 axis. +other 35392075 hsa-mir-27a Urinary Bladder Neoplasms Competing endogenous RNA network analysis suggested that lncRNA AC107027.3 may upregulate FASN by competitively binding miR-27A-3p, thereby regulating the immunotherapy response in BC. +other 35392023 hsa-mir-148a Pulmonary Disease, Chronic Obstructive The expression of CXCR1, HBEGF, TREM-1, and hsa-miR-148a-3p was more elevated in patients with COPD than in normal controls, whereas NFAT5 was decreased. +genetics_overexpression_promote 35391781 hsa-mir-543 Ovarian Neoplasms Furthermore, the overexpression of miR-543 resulted in the suppression of OvCa cell proliferation in vitro and in vivo. +genetics_overexpression_suppress 35391656 hsa-mir-432 Uterine Cervical Neoplasms Besides, overexpressed MCL1 also could reverse the enhancing effect of miR +other 35391605 hsa-mir-208b Wounds and Injuries RESULTS: Circ_0001445 and ABCG1 were decreased, and miR-208b-5p was increased in CAD patients and ox-LDL-treated HAECs. CONCLUSION: Circ_0001445 could abate ox-LDL-mediated HAEC damage by the miR-208b-5p/ABCG1 axis, providing a novel insight into the pathogenesis and treatment of CAD. +lncRNA target 35390275 hsa-mir-10b Glioma We demonstrate that the entire miR-10b-hosting HOXD locus is activated in glioma via the cis-acting mechanism involving 3D chromatin reorganization and CTCF-cohesin-mediated looping. +circRNA target 35389936 hsa-mir-1305 Uterine Cervical Neoplasms Finally, miR-1305 could target CREBRF, and circ_0009035 could regulate CREBRF expression by targeting miR-1305, thereby affecting cervical cancer tumorigenesis. In summary, our study confirmed that circ_0009035 could influence the development of cervical cancer through the targeted regulation of miR-1305/CREBRF. +genetics_knock down_suppress 35388975 hsa-mir-512 Carcinoma, Non-Small-Cell Lung CORO1C overexpression largely reversed miR +genetics_knock down_promote 35388952 hsa-mir-16 Uterine Cervical Neoplasms CONCLUSION: Knockdown of DLG1-AS1 promoted GEM sensitivity in cervical cancer cells by regulating miR +transcription factor target 35388757 hsa-mir-16 Glioblastoma CONCLUSIONS: MT inhibits the malignant progression of GBM via regulating miR5p-mediated PIM1. +circulation_biomarker_diagnosis_up 35388602 hsa-mir-181b Tuberculosis In addition, miR-181b-5p is significantly up-regulated in the peripheral blood plasma of tuberculosis patients, which has a high diagnostic value (AUC = 0.969). +genetics_overexpression_suppress 35388387 hsa-mir-4732 Adenocarcinoma of Lung 5p significantly inhibits the migration, invasion, and metastasis of LUAD in vitro and in vivo, which can be reversed by overexpression of XPR1. +circulation_biomarker_diagnosis_ns 35388333 hsa-mir-181b Angelman Syndrome RESULTS: In human AS serum and ox-LDL-induced VSMCs, circ_TNPO1 was increased, whereas miR-181b was decreased. +epigenetics 35388129 hsa-mir-148a Adenocarcinoma of Lung In the LUAD cell lines and tumor tissues from patients, miR-148a-3p was found to be significantly downregulated, while the methylation of miR-148a-3p promoter was notably increased. +transcription factor target 35387564 hsa-mir-26a Carcinoma, Hepatocellular In summary, our findings uncover a novel mechanism behind the anti-tumor effects of emodin that regulates M2 polarization via miR-26a/TGF-beta1/Akt to suppress HCC growth. +genetics_overexpression_promote 35387554 hsa-mir-19a pancreatic adenocarcinoma Overexpression of circ-MYBL2 decreased PA cell proliferation and movement, while overexpression of miR-19a showed an opposite effect. +genetics_overexpression_promote 35387544 hsa-mir-378 Rhinitis, Allergic Moreover, overexpression of CCL5 reversed miR-378g-induced effects.Conclusion: In conclusion, depletion of JP X promoted Treg/Th17 balance in AR via regulating the miR-378g/CCL5 axis. +genetics_overexpression_suppress 35386623 hsa-mir-23a Sepsis HMGB1 expression was increased and miR-23a-3p expression significantly reduced in patients with sepsis and in LPS-treated RAW264.7 cells in comparison with controls. miR-23a-3p is expressed at reduced levels during inflammation in sepsis, and overexpression of miR-23a-3p inhibits LPS-induced inflammation in murine macrophages in vitro by directly downregulating HMGB1. +other 35386538 hsa-mir-335 Mandibulofacial Dysostosis Furthermore, from the regulatory level perspective, TNC could be significantly impressed by miR5p. +other 35386454 hsa-mir-150 Multiple Myeloma Herein, for the first time, quantum dot-molecular beacon (QD-MB) functionalized MoS(2) (QD-MB @MoS(2)) fluorescent probes were designed for the dual detection of multiple myeloma (MM)-related miRNA-155 and miRNA-150. +other 35386454 hsa-mir-155 Multiple Myeloma Herein, for the first time, quantum dot-molecular beacon (QD-MB) functionalized MoS(2) (QD-MB @MoS(2)) fluorescent probes were designed for the dual detection of multiple myeloma (MM)-related miRNA-155 and miRNA-150. +lncRNA target 35386284 hsa-mir-150 Carcinoma, Hepatocellular The ceRNA network is expected to provide potential biomarkers and therapeutic targets for HCC management, especially the ZFAS1/hsa-miR5p/GINS1 regulatory axis. +genetics_GWAS 35386109 hsa-mir-449b Diabetes Mellitus The present study revealed an association between miR-27a A>G and miR-449b A>G polymorphisms and the risk of DM in Koreans, which suggests that these gene polymorphisms could represent potential markers for predicting T2DM risk. +genetics_overexpression_promote 35386035 hsa-mir-146b Glioma Overexpression of miR-146b-5p partly reversed the effects of circ_VCAN in Sev-treated glioma cells. +other 35385896 hsa-mir-9 Atrial Fibrillation OBJECTIVES: The aim of this study is to assess micro-RNAs miR-142 and miR-39 as potential biomarkers for drug-monitoring of rivaroxaban among elderly patients with atrial fibrillation. +other 35385896 hsa-mir-142 Atrial Fibrillation OBJECTIVES: The aim of this study is to assess micro-RNAs miR-142 and miR-39 as potential biomarkers for drug-monitoring of rivaroxaban among elderly patients with atrial fibrillation. +transcription factor target 35385779 hsa-mir-135a Parkinson Disease On the whole, the miR-135a-5p/Mst1 axis might serve as a potential therapeutic target in PD treatment. +other 35385711 hsa-mir-96 Sepsis CONCLUSIONS: Down-regulation of lncRNA ZFAS1 attenuated LPS-induced ALI in HSAECs by regulating the miR5p/OXSR1 axis. +other 35385711 hsa-mir-96 Acute Lung Injury CONCLUSIONS: Down-regulation of lncRNA ZFAS1 attenuated LPS-induced ALI in HSAECs by regulating the miR5p/OXSR1 axis. +circulation_biomarker_diagnosis_down 35384929 hsa-mir-199a Cervical Cancer, Hpv Infected Serum circMTO1 and miR-199a expressions were detected by reverse transcription-quantitative polymerase chain reaction, and the diagnostic efficacy of circMTO1 for CC and HR-HPV infection was analyzed by the receiver operating characteristic curve. Serum miR-199a was downregulated in HR-HPV-positive CC patients and inversely correlated with circMTO1. +circulation_biomarker_diagnosis_down 35384929 hsa-mir-199a Uterine Cervical Neoplasms Serum circMTO1 and miR-199a expressions were detected by reverse transcription-quantitative polymerase chain reaction, and the diagnostic efficacy of circMTO1 for CC and HR-HPV infection was analyzed by the receiver operating characteristic curve. Serum miR-199a was downregulated in HR-HPV-positive CC patients and inversely correlated with circMTO1. +other 35384910 hsa-mir-26 Coronary Artery Disease Downregulation of circLDLR was associated with increased miR5p in coronary artery disease tissues. +genetics_knock down_suppress 35384084 hsa-mir-206 Glioma circTCF25 was predominantly located in the cytoplasm; the combination of mir-206 and circTCF25 reverses the effects of knockdown of circTCF25 on the proliferation, migration, invasion, and tumorigenesis of glioma cells. In summary, our findings demonstrate that the circTCF25/miR-206/CypB axis plays a vital role in glioma progression, migration, invasion, and tumorigenesis. +other 35383130 hsa-mir-885 Breast Neoplasms 3p to regulate the NTRK2/PIK3CA/AKT axis. +circRNA target 35382824 hsa-mir-579 Carcinoma, Hepatocellular Circ_0036412 up-regulates GLI2 expression by competitively binding to miR3p, thus promoting the proliferation and inhibiting cell cycle arrest of HCC cells. +other 35382692 hsa-mir-4723 Triple Negative Breast Neoplasms QRT PCR showed that the expression of hsa-mir5p was down regulated in TNBC cell line MDA-MB-231 with low expression of c-myc, which was positively correlated with the expression. +other 35382622 hsa-mir-514a Angelman Syndrome CONCLUSIONS: Our study stated the vital role of the hsa_circ_0030042/miR-514a-3p/FOXO1 axis and provides a profound understanding about the circRNA in AS. +circulation_biomarker_diagnosis_ns 35382374 hsa-mir-142 Fibromyalgia Only plasma levels of miR-320a, miR-320b, and miR +circulation_biomarker_diagnosis_ns 35382172 hsa-mir-144 Crohn Disease RESULTS: A 3.33-fold increase in serum exosomal miR +other 35381856 hsa-mir-214 Fatty Liver, Alcoholic LncRNA UCA1 regulated the biological behavior of ethanol-induced L02 cells by sponging miR-214, which may provide novel therapeutic strategies for alcoholic fatty liver. +other 35381789 hsa-mir-2117 Carcinoma, Squamous Cell Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. RESULTS: RT-PCR data revealed that the expression of hsa-miR2116 and hsa-miR449c was found upregulated in AC while hsa-miR2117 was expressed in SCC cases. +other 35381789 hsa-mir-2115 Granuloma Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. +other 35381789 hsa-mir-548q Carcinoma, Squamous Cell Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. Reverse transcription polymerase chain reaction (RT-PCR) data revealed expression of hsa-miR2114 and hsa-miR548q in AC as well as SCC. +other 35381789 hsa-mir-449c Pfeiffer type acrocephalosyndactyly Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. RESULTS: RT-PCR data revealed that the expression of hsa-miR2116 and hsa-miR449c was found upregulated in AC while hsa-miR2117 was expressed in SCC cases. +other 35381789 hsa-mir-2114 Carcinoma, Squamous Cell Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. Reverse transcription polymerase chain reaction (RT-PCR) data revealed expression of hsa-miR2114 and hsa-miR548q in AC as well as SCC. +other 35381789 hsa-mir-2115 Pfeiffer type acrocephalosyndactyly Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. +other 35381789 hsa-mir-449c Carcinoma, Squamous Cell Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. RESULTS: RT-PCR data revealed that the expression of hsa-miR2116 and hsa-miR449c was found upregulated in AC while hsa-miR2117 was expressed in SCC cases. +other 35381789 hsa-mir-2117 Granuloma Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. +other 35381789 hsa-mir-2117 Pfeiffer type acrocephalosyndactyly Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. RESULTS: RT-PCR data revealed that the expression of hsa-miR2116 and hsa-miR449c was found upregulated in AC while hsa-miR2117 was expressed in SCC cases. +other 35381789 hsa-mir-2115 Carcinoma, Squamous Cell Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. +other 35381789 hsa-mir-449c Granuloma Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. +other 35381789 hsa-mir-2114 Granuloma Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. +other 35381789 hsa-mir-2114 Pfeiffer type acrocephalosyndactyly Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. Reverse transcription polymerase chain reaction (RT-PCR) data revealed expression of hsa-miR2114 and hsa-miR548q in AC as well as SCC. +other 35381789 hsa-mir-548q Pfeiffer type acrocephalosyndactyly Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. Reverse transcription polymerase chain reaction (RT-PCR) data revealed expression of hsa-miR2114 and hsa-miR548q in AC as well as SCC. +other 35381789 hsa-mir-2116 Carcinoma, Squamous Cell Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. RESULTS: RT-PCR data revealed that the expression of hsa-miR2116 and hsa-miR449c was found upregulated in AC while hsa-miR2117 was expressed in SCC cases. +other 35381789 hsa-mir-548q Granuloma Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. +other 35381789 hsa-mir-2116 Granuloma Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. +other 35381789 hsa-mir-2116 Pfeiffer type acrocephalosyndactyly Primers against hsa-miR2114, hsa-miR2115, hsa-miR2116, hsa-miR2117, hsa-miR449c, and hsa-miR548q with control RNU6 were used to screen 30 AC, 30 SCC, 5 nonspecific granulomatous inflammation, and 8 control samples. RESULTS: RT-PCR data revealed that the expression of hsa-miR2116 and hsa-miR449c was found upregulated in AC while hsa-miR2117 was expressed in SCC cases. +circulation_biomarker_diagnosis_up 35381590 hsa-mir-4639 Glomerulonephritis, IGA With an average follow-up of 8 months, miR-4639 and miR-210 expressions in plasma and urinary exosomes were higher in patients with progressive IgAN. +circulation_biomarker_diagnosis_up 35381590 hsa-mir-210 Glomerulonephritis, IGA With an average follow-up of 8 months, miR-4639 and miR-210 expressions in plasma and urinary exosomes were higher in patients with progressive IgAN. +lncRNA target 35381577 hsa-mir-216a Osteoporosis, Postmenopausal The lncMIAT/miR-216a/p38MAPK signaling contributed predominantly to the increased inflammatory cytokine secretion in the PBMCs from postmenopausal osteoporosis. lncMIAT/miR-216a axis was critical for the regulation of AMPK/p38MAPK signaling, which may be a promising therapeutic target for osteoporosis treatment by inflammatory cytokine inhibition. +other 35381488 hsa-mir-103 Langer mesomelic dysplasia It has been reasonably hypothesized that miR-103 may play a crucial role, which regulate skeletal muscle development of LMB. +circulation_biomarker_diagnosis_ns 35381457 hsa-mir-155 Breast Neoplasms Here, a biosensor based on surface enhanced Raman spectroscopy (SERS) combined with catalytic hairpin assembly (CHA) amplification technology was developed for ultra-sensitive detection of miRNA-21 and miRNA-155 in breast cancer serum. +circulation_biomarker_diagnosis_ns 35381457 hsa-mir-21 Breast Neoplasms Here, a biosensor based on surface enhanced Raman spectroscopy (SERS) combined with catalytic hairpin assembly (CHA) amplification technology was developed for ultra-sensitive detection of miRNA-21 and miRNA-155 in breast cancer serum. +other 35381016 hsa-mir-628 COVID-19 5p) independently classifies COVID-19 cases with 100% accuracy. +other 35381016 hsa-mir-93 COVID-19 5p) independently classifies COVID-19 cases with 100% accuracy. +exosome 35380635 hsa-mir-23b salivary gland adenoid cystic carcinoma We investigated the effect of exosomal miR-23b-3p on the progression of SACC. +genetics_knock down_suppress 35380509 hsa-mir-532 Ovarian Neoplasms Circ_0007841 knockdown confers cisplatin sensitivity to ovarian cancer cells by down-regulation of NFIB expression in a miR-532-5p-dependent manner. +other 35380290 hsa-mir-140 Hypoxia-Ischemia, Brain 5p attenuates HIBD and supplies a novel perspective for HIBD management. +other 35380163 hsa-mir-223 Granulomatosis with Polyangiitis A distinction between GPA and healthy controls was the best for miR3p, whereas miR-664a-3p discriminated between active vs. +other 35380163 hsa-mir-664a Granulomatosis with Polyangiitis A distinction between GPA and healthy controls was the best for miR3p, whereas miR-664a-3p discriminated between active vs. +genetics_GWAS 35379867 hsa-mir-27a Bipolar Disorder Our study highlights the importance of miR-27a and its polymorphism at rs895819 in bipolar disorder. +other 35379844 hsa-mir-1 Pulmonary Disease, Chronic Obstructive Additionally, in patients with COPD, we identified miR3p as a miRNA induced by smoking. +other 35379829 hsa-mir-125b Coronary Artery Disease Interestingly, miRNAs as miR-125b playing a role in vascular calcification were differentially expressed in the classical subset in patients suffering from CAD and not MI in comparison to control samples. +target gene 35379785 hsa-mir-4731 Breast Neoplasms Tumor suppressive role of microRNA-4731-5p in breast cancer through reduction of PAICS-induced FAK phosphorylation. +other 35379653 hsa-mir-6125 Hepatitis, Autoimmune Histological analysis demonstrated that the expression levels of miR-3196, miR-6125 and miR-4634 in patients with AIH and OS were correlated with severe hepatic necroinflammatory activity. +other 35379653 hsa-mir-4634 Hepatitis, Autoimmune Histological analysis demonstrated that the expression levels of miR-3196, miR-6125 and miR-4634 in patients with AIH and OS were correlated with severe hepatic necroinflammatory activity. +other 35379653 hsa-mir-196 Hepatitis, Autoimmune Histological analysis demonstrated that the expression levels of miR-3196, miR-6125 and miR-4634 in patients with AIH and OS were correlated with severe hepatic necroinflammatory activity. +lncRNA target 35379225 hsa-mir-218 Ventricular Premature Complexes 5p in endometrial microenvironment prevents the migration of ectopic endometrial stromal cells by inhibiting LASP1. +other 35379225 hsa-mir-218 Endometriosis METHODS: Herein, qPCR was performed to analyze the expression levels of LASP1 and miR5p between endometriosis (Ems) cells and control cells. +other 35379158 hsa-mir-24-1 Carcinoma, Hepatocellular 1-5p was a novel biomarker for HCC diagnosis identified in this study. +genetics_knock down_suppress 35379058 hsa-mir-653 Adenocarcinoma of Lung Furthermore, miR-653 silence or HK2 addition neutralized the effects of circ_0061140 knockdown on LUAD progression under hypoxia. This study elaborated that circ_0061140 accelerated hypoxia-triggered glycolysis, migration and invasion in LUAD cells via downregulating miR-653 and increasing HK2 expression. +transcription factor target 35379056 hsa-mir-222 Medulloblastoma 3p suppressed cell viability, altered cell cycle distribution, and inhibited the formation of MB stem-like cells via the Notch2/c-myc pathway. +other 35378915 hsa-mir-105-2 Adenocarcinoma of Lung 2 were closely related to the TME and affected the prognosis of LUAD by altering the abundance of TICs. +other 35378915 hsa-mir-873 Adenocarcinoma of Lung 2 were closely related to the TME and affected the prognosis of LUAD by altering the abundance of TICs. +other 35378789 hsa-mir-363 Endometriosis In our research, we aim to investigate the role of miR-363 in the pathogenesis of endometriosis. +genetics_knock down_promote 35378711 hsa-mir-1305 Uterine Cervical Neoplasms Knockdown of circ_0005576 suppressed the proliferation, migration, and invasion of CC cells, while the silence of miR-1305 facilitated the development of CC cells. +genetics_overexpression_promote 35378649 hsa-mir-338 Uterine Cervical Neoplasms Overexpression of DSCAM-AS1 promoted cervical carcinoma cell growth and cycle via regulating miR +genetics_overexpression_promote 35378445 hsa-mir-600 Colorectal Neoplasms Overexpression of MIR600HG affected the expression of downstream molecules, such as miR +transcription factor target 35378380 hsa-mir-142 Inflammation Taken together, our results suggest that miR3p and miR-451 released in EVs by activated neutrophils can target EC to trigger an inflammatory cascade and induce direct vascular damage, and that therapeutic strategies based on the inhibition of these miRNAs in ECs will have implications for neutrophil-mediated inflammatory diseases. +other 35378380 hsa-mir-223 Inflammation Importantly, miR-223, miR3p and miR-451 are markedly increased in kidney biopsies from patients with active ANCA-associated vasculitis, a severe autoimmune disease that is prototypical of a neutrophil-induced microvascular damage. +transcription factor target 35378380 hsa-mir-451 Inflammation Taken together, our results suggest that miR3p and miR-451 released in EVs by activated neutrophils can target EC to trigger an inflammatory cascade and induce direct vascular damage, and that therapeutic strategies based on the inhibition of these miRNAs in ECs will have implications for neutrophil-mediated inflammatory diseases. +other 35378300 hsa-mir-495 Osteoarthritis Collectively, these findings revealed a protective effect of circVMA21in OA by intercepting the miR3p/FBWX7 crosstalk. +epigenetics 35378241 hsa-mir-182 Inflammatory Bowel Diseases 5p aggravates UC by inactivating the Wnt/beta-catenin signaling pathway through DNMT3A-mediated SMARCA5 methylation. +other 35378210 hsa-mir-142 Gout In addition, the results suggested that the lncRNA-NEAT1-miR3p-IL-6 pathway may be a potential RNA regulatory pathway that controls the progression of gout disease. +other 35378083 hsa-mir-34a Chemical and Drug Induced Liver Injury These results indicated that imbalance in macrophages M1/M2 polarization mediated by activation of Notch signaling due to reduced miR-34a-5p level may contribute to additive effects on disorder of inflammatory factors secretion and subsequent liver injury following long-term DBP and BaP co-exposure. +genetics_overexpression_promote 35377982 hsa-mir-34a Triple Negative Breast Neoplasms Overexpression of WTAPP1 and EEF2K increased proliferation, invasion and migration of TNBC cells, while overexpression of miR-34a showed different results. +genetics_overexpression_promote 35377981 hsa-mir-203 Osteosarcoma FAM230B overexpression in OS cells increased premature miR-203 level and decreased mature miR-203 level. +exosome 35377980 hsa-mir-92a Liver Neoplasms Tumor fibroblast-derived exosome marker proteins and miR-92a-3p have good diagnostic value in liver cancer, indicating that they may be new diagnostic markers for liver cancer. +lncRNA target 35377979 hsa-mir-93 Carcinoma, Hepatocellular 5p on HCC cell growth may be carried out by inhibiting the PCK1 expression, suggesting that miR +other 35377267 hsa-mir-375 Diabetes Mellitus MicroRNA-375 (miR-375) is upregulated in the islets of some diabetics and is correlated with poor outcome. +lncRNA target 35377130 hsa-mir-559 Atherosclerosis With high level of ASLNC18810 in ECs, ASLNC18810 binds to miR-559 as a miRNA sponge and suppresses the inhibition effect of miR-559 on Bax protein, this direct positive transcriptional regulation between HIF-1alpha and Bax endows the apoptotic property in ECs induced by Ox-LDL. +lncRNA target 35373434 hsa-mir-185 Diabetic Retinopathy Collectively, our findings reveal a novel lncRNA FAF/miR5p/PAK2 axis as a crucial regulator in cardiomyocyte pyroptosis, which might be a potential therapeutic target of AMI. +lncRNA target 35373434 hsa-mir-185 Syphilis Collectively, our findings reveal a novel lncRNA FAF/miR5p/PAK2 axis as a crucial regulator in cardiomyocyte pyroptosis, which might be a potential therapeutic target of AMI. +circRNA target 35373391 hsa-mir-873 Thyroid Cancer, Papillary CONCLUSION: Circ_0058129 expedited PTC progression through the miR +lncRNA target 35373390 hsa-mir-421 Colorectal Neoplasms CONCLUSION: Caudatin inhibited CRC cell malignancy through the hsa_circ_0060927/miR-421/miR +lncRNA target 35373390 hsa-mir-195 Colorectal Neoplasms CONCLUSION: Caudatin inhibited CRC cell malignancy through the hsa_circ_0060927/miR-421/miR +circRNA target 35372340 hsa-mir-451a Thyroid Cancer, Papillary We further found that miR-451a inhibited PTC cell proliferation, migration, and invasion by regulating S1PR2. +lncRNA target 35372039 hsa-mir-552 Breast Neoplasms SLC16A1-AS1 inhibits BC carcinogenesis and progression via the SLC16A1-AS1/miR +circulation_biomarker_diagnosis_down 35371977 hsa-mir-181a Glioblastoma Furthermore, miR-181a-5p was detected in GBM cell-derived extracellular vesicles (EVs) as well as patient serum-derived EVs. +lncRNA target 35371970 hsa-mir-138 Mouth Neoplasms MiR-138 mimics and inhibitors were used to functionally investigate the role of miR-138 on CAF phenotype and the resulting change in their ability to support OSCC invasion. +lncRNA target 35371970 hsa-mir-138 Squamous Cell Carcinoma of Head and Neck This study aimed to investigate miR-138 dysregulation in CAFs in oral squamous cell carcinoma (OSCC) and its effects on their phenotype and invasion of adjacent OSCC cells. +transcription factor target 35371347 hsa-mir-130b Hydrocephalus Moreover, upregulated hsa-miR-130b-3p might mediate the downregulation of the phosphatase and tensin homolog gene (PTEN), which has been associated with hydrocephalus, via binding to its 3'-untranslated region by dual-luciferase reporter assay. +circulation_biomarker_prognosis_up 35371343 hsa-mir-200a Carcinoma, Ovarian Epithelial ROC analysis showed that the expression of serum miR-200a/b can distinguish EOC patients from the control group. +circulation_biomarker_prognosis_up 35371343 hsa-mir-200b Carcinoma, Ovarian Epithelial ROC analysis showed that the expression of serum miR-200a/b can distinguish EOC patients from the control group. +lncRNA target 35371339 hsa-mir-221 Squamous Cell Carcinoma of Head and Neck In conclusion, for the first time, we demonstrated lncRNA LEF1-AS1 as a novel biomarker for HNSCC and suggested LEF1-AS1/miR5p/GJA1 axis as promising diagnostic and therapeutic target for HSCC treatment. +lncRNA target 35371326 hsa-mir-184 Carcinoma, Renal Cell 5p regulated A-498 and 786-O cell proliferation, invasion and apoptosis by directly targeting NUS1. +genetics_knock down_promote 35371319 hsa-mir-421 Adenocarcinoma of Lung Gain- and loss-of-function assays showed that miR-421 promoted LUAD cell migration and invasion. +transcription factor target 35371310 hsa-mir-145 Glioma Taken together, these results suggest that miR5p could be a novel therapeutic target for gliomas through the suppression of TCTP in GSCs. +circulation_biomarker_prognosis_down 35371309 hsa-mir-34a Carcinoma, Hepatocellular Conclusions: Collectively, serum exosomal miR-34a is significantly down-regulated in HCC patients and might be a novel noninvasive biomarker for diagnosis and prognosis of HCC. +lncRNA target 35371308 hsa-mir-130b Glioblastoma Conclusions: CircASPM can promote GBM progression via regulating miR-130b-3p/E2F1 axis, suggesting that circAPSM could provide an effective biomarker for GBM diagnosis and prognostic evaluation and possibly being used for molecular targeted therapy. +target gene 35371298 hsa-let-7b Ovarian Neoplasms Radix ranunculus temate saponins sensitizes ovarian cancer to Taxol via upregulation of miR-let-7b. +other 35370692 hsa-mir-802 Diabetic Nephropathies Among them, miR-802, miR-34a, miR-132, miR-101a, and mir-379 were the most upregulated ones in diabetic kidneys. +other 35370692 hsa-mir-132 Diabetic Nephropathies Among them, miR-802, miR-34a, miR-132, miR-101a, and mir-379 were the most upregulated ones in diabetic kidneys. +other 35370692 hsa-mir-101a Diabetic Nephropathies Among them, miR-802, miR-34a, miR-132, miR-101a, and mir-379 were the most upregulated ones in diabetic kidneys. +other 35370692 hsa-mir-379 Diabetic Nephropathies Among them, miR-802, miR-34a, miR-132, miR-101a, and mir-379 were the most upregulated ones in diabetic kidneys. +other 35370692 hsa-mir-34a Diabetic Nephropathies Among them, miR-802, miR-34a, miR-132, miR-101a, and mir-379 were the most upregulated ones in diabetic kidneys. +epigenetics 35370461 hsa-mir-571 Hypertension Conclusions: Our study suggested that hydroxymethylation in the promoter regions controlled the level of miR-3571 and revealed the important roles of miR-3571 and CLDN1 in VSMCs during the development of hypertension. +lncRNA target 35370458 hsa-mir-204 Esophageal Squamous Cell Carcinoma 5p inhibited cell proliferation and induced cell apoptosis in ESCC through targeting Nestin, which might provide novel therapeutic targets for ESCC therapy. +other 35369902 hsa-mir-31 Multiple Myeloma CONCLUSION: Our findings highlight a novel mechanism, in which circPSAP functions as a miR3p sponge to impact MM cell proliferation, apoptosis and BTZ sensitivity by regulating HDAC4 expression. +lncRNA target 35369850 hsa-mir-145 Hypertension, Pulmonary 5p/Akt3 was supposed to perform as a prospective molecular target for the treatment of PH. +other 35369634 hsa-mir-125b Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: Detection of miRNA-125b expression level is complementary to MRI diagnosis of head and neck SCC. +circulation_biomarker_diagnosis_ns 35368948 hsa-mir-92a Urinary Bladder Neoplasms OBJECTIVE: To study the clinical value of Xiaozheng decoction combined with bladder perfusion treating bladder cancer after the operation and its effect on serum miR-143 and miR-92a. +circulation_biomarker_diagnosis_ns 35368948 hsa-mir-143 Urinary Bladder Neoplasms OBJECTIVE: To study the clinical value of Xiaozheng decoction combined with bladder perfusion treating bladder cancer after the operation and its effect on serum miR-143 and miR-92a. +lncRNA target 35368896 hsa-mir-454 Carcinoma, Renal Cell CONCLUSION: ZONs treatment notably impeded proliferation, lipid accumulation, and oxidation in RCC cells, through upregulating miR +other 35368799 hsa-mir-182 Colorectal Neoplasms Increased levels of miR-223 and miR-182 were associated with increased risk of disease progression, and the more accurate the value of miR-223 and miR-182, the earlier the diagnosis of colorectal cancer. +other 35368799 hsa-mir-223 Colorectal Neoplasms Increased levels of miR-223 and miR-182 were associated with increased risk of disease progression, and the more accurate the value of miR-223 and miR-182, the earlier the diagnosis of colorectal cancer. +lncRNA target 35368795 hsa-mir-708 Osteoporosis Therefore, we hypothesized that TMC3-AS1 could inhibit osteoblast apoptosis and interact with miR-708, a regulator of osteoblast apoptosis in OS. +other 35368701 hsa-mir-20b Arthritis, Rheumatoid The networks containing tissue-specific expressed hub genes are as follows: ARAP1-AS2/miR-20b-3p/TRIM3, ARAP1-AS2/miR-30c-3p/FRZB. +lncRNA target 35368699 hsa-mir-145 Prostatic Neoplasms 5p can inhibit NED and tumor growth by targeting SOX11, which regulates the expression of MYCN, and that this could be a novel therapeutic strategy for preventing the progression of PCa. +circulation_biomarker_diagnosis_up 35368523 hsa-mir-1 Diabetic Neuropathies 3p was downregulated (Fold change = 0.9, P = 0.028) in whole blood samples from DN patients compared to the control group. +lncRNA target 35367965 hsa-mir-34b Mental Disorders RESULTS: miRNA array data and correlation analysis showed that miR-34b was the most relevant miRNA among Pb neurotoxicity and neuropsychiatric disorders, and synapse-associated membrane protein 2 (VAMP2) was the target gene regulating synapse function. CONCLUSION: Early-life Pb exposure might exert synapse-toxic effects via inhibiting VAMP2 mediated by upregulation of miR-34b and shed a light on the underlying relationship between Pb neurotoxicity and developmental neuropsychiatric disorders. +lncRNA target 35367965 hsa-mir-34b Neurodevelopmental Disorders CONCLUSION: Early-life Pb exposure might exert synapse-toxic effects via inhibiting VAMP2 mediated by upregulation of miR-34b and shed a light on the underlying relationship between Pb neurotoxicity and developmental neuropsychiatric disorders. +lncRNA target 35367362 hsa-mir-27a Carcinoma, Non-Small-Cell Lung MALAT1 facilitated tumor growth in vivo via targeting miR-27a-5p/PBOV1 and enhanced resistance of NSCLC cells to GEM. +genetics_knock down_promote 35367291 hsa-mir-34a Hearing Loss, Age-Related Our previous studies revealed that miR-34a suppresses autophagy in the ageing cochlea, which correlates with cochlear hair cell loss and age-related hearing loss (AHL). These findings open new avenues for protection against AHL through miR-34a/ATG9a/TFEB modulation of autophagy. +other 35366907 hsa-mir-125a Adenocarcinoma of Lung Among all DEMs of the three subgroups, five miRNAs (miR-30c-5p, miR-30e-5p, miR-500a-3p, miR-125a-5p, and miR-99a-5p) were also significantly associated with overall survival of lung adenocarcinoma patients. +other 35366907 hsa-mir-500a Adenocarcinoma of Lung Among all DEMs of the three subgroups, five miRNAs (miR-30c-5p, miR-30e-5p, miR-500a-3p, miR-125a-5p, and miR-99a-5p) were also significantly associated with overall survival of lung adenocarcinoma patients. +other 35366907 hsa-mir-99a Adenocarcinoma of Lung Among all DEMs of the three subgroups, five miRNAs (miR-30c-5p, miR-30e-5p, miR-500a-3p, miR-125a-5p, and miR-99a-5p) were also significantly associated with overall survival of lung adenocarcinoma patients. +other 35366766 hsa-mir-3 Diabetic Nephropathies It is suggested that miR-33 and ABCA1 genes evaluation could be a new therapeutic strategy for nephropathy diabetes remediation. +other 35366759 hsa-mir-149 Genital Diseases, Male Moreover, abundant microRNAs within HSerCs-EVs (miR-638, miR3p, miR-1246, etc.) had a possible impact on male reproductive disorders such as asthenozoospermia and oligozoospermia. +other 35366759 hsa-mir-1246 Genital Diseases, Male Moreover, abundant microRNAs within HSerCs-EVs (miR-638, miR3p, miR-1246, etc.) had a possible impact on male reproductive disorders such as asthenozoospermia and oligozoospermia. +other 35366759 hsa-mir-149 Asthenozoospermia Moreover, abundant microRNAs within HSerCs-EVs (miR-638, miR3p, miR-1246, etc.) had a possible impact on male reproductive disorders such as asthenozoospermia and oligozoospermia. +other 35366759 hsa-mir-149 Oligospermia Moreover, abundant microRNAs within HSerCs-EVs (miR-638, miR3p, miR-1246, etc.) had a possible impact on male reproductive disorders such as asthenozoospermia and oligozoospermia. +other 35366759 hsa-mir-638 Oligospermia Moreover, abundant microRNAs within HSerCs-EVs (miR-638, miR3p, miR-1246, etc.) had a possible impact on male reproductive disorders such as asthenozoospermia and oligozoospermia. +other 35366759 hsa-mir-1246 Oligospermia Moreover, abundant microRNAs within HSerCs-EVs (miR-638, miR3p, miR-1246, etc.) had a possible impact on male reproductive disorders such as asthenozoospermia and oligozoospermia. +other 35366759 hsa-mir-638 Asthenozoospermia Moreover, abundant microRNAs within HSerCs-EVs (miR-638, miR3p, miR-1246, etc.) had a possible impact on male reproductive disorders such as asthenozoospermia and oligozoospermia. +other 35366759 hsa-mir-1246 Asthenozoospermia Moreover, abundant microRNAs within HSerCs-EVs (miR-638, miR3p, miR-1246, etc.) had a possible impact on male reproductive disorders such as asthenozoospermia and oligozoospermia. +other 35366759 hsa-mir-638 Genital Diseases, Male Moreover, abundant microRNAs within HSerCs-EVs (miR-638, miR3p, miR-1246, etc.) had a possible impact on male reproductive disorders such as asthenozoospermia and oligozoospermia. +transcription factor target 35366755 hsa-mir-214 Acute Kidney Injury According to these findings, inhibiting miR3p would alleviate TEC ferroptosis in cis-AKI via GPX4. +circulation_biomarker_diagnosis_down 35366691 hsa-mir-17 Endometriosis This study investigated the diagnostic value of serum miR +circulation_biomarker_diagnosis_down 35366691 hsa-mir-424 Endometriosis This study investigated the diagnostic value of serum miR +circulation_biomarker_diagnosis_ns 35366615 hsa-mir-518 Diabetes, Gestational CONCLUSION: High expression of miR-518 assists the diagnosis of GDM and GDM&HDCP, and miR-518 regulates the serum inflammatory factors by inhibiting PPARalpha. +genetics_knock down_promote 35366388 hsa-mir-223 Carcinoma, Hepatocellular Both knockdown of miR-223 and overexpression of ECT2 and FAT1 reversed FGD5-AS1 silencing-mediated suppression of HCC cell proliferation and stemness. +genetics_overexpression_promote 35366327 hsa-mir-215 Breast Neoplasms 5p or overexpression of SREBP1 promoted the tumorigenic behaviors of BC cells by stimulating lipid metabolism and counteracted the antitumor effect of Al-MPS. +other 35365601 hsa-mir-592 Neurodevelopmental Disorders The findings demonstrate that miR-592 might play a novel role in treating the neurodevelopmental-associated disorder. +exosome 35365456 hsa-let-7d Down Syndrome CONCLUSION: Let-7d-5p in amniotic fluid exosomes may promote oxidative stress events in the brain of fetuses with DS by regulating BACH1 expression. +lncRNA target 35365349 hsa-mir-135b Osteolysis Taken together, our findings suggest that LINC01534/miR-135b-5p/PTPRT axis might be a valuable therapeutic target for the treatment of debris-induced osteolysis. +lncRNA target 35365168 hsa-mir-362 Mouth Neoplasms 5p and miR-500b-5p and recruiting CEBPB, thereby promoting OSCC progression via NFkappaB signaling pathway. +other 35365098 hsa-mir-205 Urinary Bladder Neoplasms 3p) yielded an Area Under the Curve (AUC) of 0.92 /- 0.06 in discriminating between BC and CTRL, an accuracy which was superior either to miRNAs (AUC = 0.84 /- 0.03) or SERS data (AUC = 0.84 /- 0.05) individually. +other 35365098 hsa-mir-210 Urinary Bladder Neoplasms 3p) yielded an Area Under the Curve (AUC) of 0.92 /- 0.06 in discriminating between BC and CTRL, an accuracy which was superior either to miRNAs (AUC = 0.84 /- 0.03) or SERS data (AUC = 0.84 /- 0.05) individually. +other 35365098 hsa-mir-34a Urinary Bladder Neoplasms 3p) yielded an Area Under the Curve (AUC) of 0.92 /- 0.06 in discriminating between BC and CTRL, an accuracy which was superior either to miRNAs (AUC = 0.84 /- 0.03) or SERS data (AUC = 0.84 /- 0.05) individually. +genetics_overexpression_suppress 35364459 hsa-mir-205 Angelman Syndrome 5p in the progression of human aortic vascular smooth muscle cells (HAVSMCs) METHODS: Use ox-LDL to induce HAVSMCs to construct an in vitro cell model of AS, and silence/overexpress miR +lncRNA target 35364458 hsa-mir-106b Adenocarcinoma of Lung In conclusion, HNRNPA2B1 inhibits SFRP2 and activates Wnt-beta/catenin via m6A-mediated maturing of miR-106b-5p to aggravate stemness and LUAD progression, which potentially offered HNRNPA2B1 as a potential marker in CSCs-targeted treatment for LUAD. +lncRNA target 35364057 hsa-mir-940 Esophageal Squamous Cell Carcinoma CONCLUSION: Our findings suggested that GATA2-AS1, expressed at low levels in ESCC, plays a crucial role in the progression of ESCC by targeting the miR-940/PTPN12 axis and could be a potential drug target to treat ESCC patients. +transcription factor target 35363937 hsa-mir-126 Colorectal Neoplasms Previously, we showed that miR-126 functions as a tumour suppressor in CRC and is inversely correlated with tumour proliferation, metastasis and patient prognosis. +genetics_overexpression_promote 35363355 hsa-mir-490 Colonic Neoplasms In addition, overexpression of miR +other 35363256 hsa-mir-374a Inflammatory Bowel Diseases Our findings suggest that miR-374a-5p reduction is a central driver of inflammation in IBD, and its therapeutic supplementation could reduce monocyte-driven inflammation in IBD or other immune-mediated diseases. +genetics_overexpression_promote 35363093 hsa-mir-625 Carcinoma, Non-Small-Cell Lung Furthermore, LRRC8E overexpression abolished the promotive effect of miR-625 abundance on the DDP sensitivity in DDP-resistant NSCLC cells. +lncRNA target 35363088 hsa-mir-143 Retinal Neovascularization Intravitreal injection of synthetic miR-143 mimics significantly ameliorate retinal neovascularization in OIR rats. These findings suggest that miR-143 appears to be essential for limiting endothelial cell-matrix adhesion, thus suppressing retinal neovascularization. +other 35363088 hsa-mir-143 osteogenesis imperfecta type 1 Intravitreal injection of synthetic miR-143 mimics significantly ameliorate retinal neovascularization in OIR rats. +other 35363088 hsa-mir-143 Retinal Diseases In this study, we show that miR3p is significantly downregulated in the retina of a rat model of oxygen-induced retinopathy (OIR) by miRNA-sequencing. +lncRNA target 35362879 hsa-mir-186 Urinary Bladder Neoplasms Our study identified that circ3323 modulates metastasis of BCa through miR5p/APP axis and may serve as a promising prognostic biomarker for BCa, which provides novel insights into treatment of BCa. +genetics_overexpression_promote 35362548 hsa-mir-129 Colorectal Neoplasms 5p overexpression reduced TRIP13 expression. +other 35362387 hsa-mir-668 Diabetes Mellitus, Type 2 Our findings showed that Tincr sponged miR3p, which attenuated abnormal IESC differentiation in DM by regulating Klf3 expression. +lncRNA target 35362116 hsa-mir-451 Osteoarthritis The goals of this study were to evaluate crosstalk between these signaling pathways and determine if miR-122 and miR-451 exert their protective/destructive effects through these pathways in an in vitro model of OA. +lncRNA target 35362116 hsa-mir-122 Osteoarthritis The goals of this study were to evaluate crosstalk between these signaling pathways and determine if miR-122 and miR-451 exert their protective/destructive effects through these pathways in an in vitro model of OA. +other 35361385 hsa-mir-202 Pre-Eclampsia MATERIALS AND METHODS: Quantitative real-time PCR was utilized to determine the expression of NORAD, microRNA (miR)5p, and fragile X-related gene 1 (FXR1) in PE and normal placenta tissues. +genetics_overexpression_promote 35361384 hsa-mir-599 Uterine Cervical Neoplasms Functionally, overexpression of miR-599 suppressed cell proliferation, migration, and invasion of cervical cancer cells, while downregulation of miR-599 had opposite effects. +other 35360844 hsa-mir-152 Craniosynostoses Moreover, the luciferase reporter assay revealed that the regulatory axis and HOTAIR-miRCAMKIIalpha were the regulatory mechanisms of HOTAIR in the osteoclast function and development of craniosynostosis.In this study, our data showed that HOTAIR could promote osteoclast differentiation by binding miR-152. +other 35360454 hsa-mir-206 Muscular Injury Experimental results indicated that injury caused by radiation persisted despite gradual healing of the TVP muscle and miR-206 regulatory pathway plays a key role in regulating radiation-induced muscle injury. +other 35360081 hsa-mir-1247 Osteoporosis, Postmenopausal 5p, which were associated with bone mineral density (BMD), may serve as candidate diagnostic biomarkers as well as potentially contribute to pathophysiology of PMOP. +other 35360081 hsa-mir-766 Osteoporosis, Postmenopausal 5p, which were associated with bone mineral density (BMD), may serve as candidate diagnostic biomarkers as well as potentially contribute to pathophysiology of PMOP. +other 35360081 hsa-mir-24 Osteoporosis, Postmenopausal 5p, which were associated with bone mineral density (BMD), may serve as candidate diagnostic biomarkers as well as potentially contribute to pathophysiology of PMOP. +other 35360081 hsa-mir-124 Osteoporosis, Postmenopausal 5p, which were associated with bone mineral density (BMD), may serve as candidate diagnostic biomarkers as well as potentially contribute to pathophysiology of PMOP. +other 35360081 hsa-mir-30 Osteoporosis, Postmenopausal 5p, which were associated with bone mineral density (BMD), may serve as candidate diagnostic biomarkers as well as potentially contribute to pathophysiology of PMOP. +circulation_biomarker_diagnosis_down 35359635 hsa-mir-126 Multiple Sclerosis Serum miR +other 35359454 hsa-mir-210 psoriasis 1 Importantly, IFNgamma-sEVs significantly improved the delivery efficiency and stability of ASO-210, the antisense oligonucleotides of miR-210 block the immune imbalance and subsequent psoriasis development. +transcription factor target 35359405 hsa-mir-223 Lymphoma, Large B-Cell, Diffuse Our study uncovers a negative functional loop consisting of a Fbw7-mediated LDHA/lactate/miR-223 axis, which may support the future ABC-DLBCL therapy by targeting LDHA-related inhibition. +lncRNA target 35359381 hsa-mir-370 Glioma CONCLUSIONS: Silencing of CHRM3-AS2 expression inhibited the malignant progression of glioma by regulating miR +genetics_knock down_promote 35359342 hsa-mir-138 Carcinoma, Hepatocellular 5p inhibition partially suppressed the effects of circ-TLK1 knockdown on the malignant behaviors of HCC cells. +circulation_biomarker_diagnosis_ns 35359267 hsa-mir-92a Colorectal Neoplasms A Prussian blue nanoparticles-based fluorescent nanoprobe for monitoring Since microRNA-92a (miR-92a) and microRNA-21 (miR-21) are crucial biomarkers for colorectal cancer (CRC), monitoring miR-92a and miR-21 in serum is very significant for the early diagnosis of CRC. +circulation_biomarker_diagnosis_ns 35359267 hsa-mir-21 Colorectal Neoplasms A Prussian blue nanoparticles-based fluorescent nanoprobe for monitoring Since microRNA-92a (miR-92a) and microRNA-21 (miR-21) are crucial biomarkers for colorectal cancer (CRC), monitoring miR-92a and miR-21 in serum is very significant for the early diagnosis of CRC. +lncRNA target 35359242 hsa-mir-671 Parkinson Disease 5p to inhibit NF-kappaB in IS models, which provided a theoretical foundation for the protective effect of downregulating ANRIL for IS patients. +lncRNA target 35359242 hsa-mir-671 Ischemic Stroke 5p to inhibit NF-kappaB in IS models, which provided a theoretical foundation for the protective effect of downregulating ANRIL for IS patients. +other 35358781 hsa-mir-197 Neuroblastoma 5p-E2F1 axis in neuroblastoma metastasis and growth. +lncRNA target 35358777 hsa-mir-205 Liver Diseases, Alcoholic mediated importinalpha5 inhibition via the NF-kappaB signaling pathway, highlighting a promising therapeutic target for ALD treatment with the help of traditional Chinese medicine. +lncRNA target 35358766 hsa-mir-20a Stomatognathic Diseases CONCLUSION: MiR-20a up-regulation accelerated the viability, migration and osteogenic/odontoblastic differentiation potential of DPSCs by regulating NF-kappaB/p65 signaling pathway via targeting IL-8, which might be a potential treatment target for dental diseases. +other 35358709 hsa-mir-130a Arthritis, Rheumatoid MiR-130a-3p is a disease-related miRNA and Kruppel-like factor 9 (KLF9) is a zinc finger transcription factor, which are involved in RA pathogenesis. +lncRNA target 35358540 hsa-mir-128 Gastrointestinal Stromal Tumors In summary, SNHG16 up-regulated by CTCF facilitated the progression of GIST through miR +other 35358479 hsa-mir-96 Colorectal Neoplasms Collectively, we identified a novel mechanism of beta-catenin/miR-183/96/182 cluster/FOXO1 mediated-CRC cellular senescence that entails that AVN C serves as an auxiliary agent for CRC treatment. +other 35358479 hsa-mir-182 Colorectal Neoplasms Collectively, we identified a novel mechanism of beta-catenin/miR-183/96/182 cluster/FOXO1 mediated-CRC cellular senescence that entails that AVN C serves as an auxiliary agent for CRC treatment. +other 35358479 hsa-mir-183 Colorectal Neoplasms Collectively, we identified a novel mechanism of beta-catenin/miR-183/96/182 cluster/FOXO1 mediated-CRC cellular senescence that entails that AVN C serves as an auxiliary agent for CRC treatment. +genetics_GWAS 35358276 hsa-mir-499 Autoimmune Diseases Association between miRNA-499 gene polymorphism and autoimmune diseases: A INTRODUCTION: The association between miRNA-499 rs3746444 and a variety of autoimmune diseases has been reported. CONCLUSIONS: Our meta-analysis suggested that the miRNA-499 rs3746444 polymorphism was associated with an elevated risk of autoimmune diseases in the overall analysis as well as Caucasian and Asian populations. +lncRNA target 35358000 hsa-mir-584 Urinary Bladder Neoplasms CircLONP2 depletion inhibited cell viability, proliferation, and invasion of BC cell lines, which could be partially rescued by miR +other 35357625 hsa-mir-150 Myocardial Infarction METHODS AND RESULTS: A myocardial ischemia (MI) injury rat model was constructed to detect miR5p and tetratricopeptide repeat domain 5 (TTC5) expression during heart ischemia injury. +other 35357625 hsa-mir-150 Myocardial Ischemia METHODS AND RESULTS: A myocardial ischemia (MI) injury rat model was constructed to detect miR5p and tetratricopeptide repeat domain 5 (TTC5) expression during heart ischemia injury. +lncRNA target 35357586 hsa-mir-548c Colorectal Neoplasms Mechanistically, LINC01088 bound directly to miR-548b-5p and miR-548c-5p that were significantly upregulated Ras GTPase-activating protein-binding proteins 1 (G3BP1) and programmed death ligand 1 (PD-L1) expression, altering CRC cell phenotypes. CONCLUSION: Overall, these findings suggested that LINC01088 directly targeted miR-548b-5p and miR-548c-5p, promoting G3BP1 and PD-L1 expression, which facilitated colorectal cancer progression and immune escape. +lncRNA target 35357586 hsa-mir-548b Colorectal Neoplasms Mechanistically, LINC01088 bound directly to miR-548b-5p and miR-548c-5p that were significantly upregulated Ras GTPase-activating protein-binding proteins 1 (G3BP1) and programmed death ligand 1 (PD-L1) expression, altering CRC cell phenotypes. CONCLUSION: Overall, these findings suggested that LINC01088 directly targeted miR-548b-5p and miR-548c-5p, promoting G3BP1 and PD-L1 expression, which facilitated colorectal cancer progression and immune escape. +lncRNA target 35357550 hsa-mir-214 Carcinoma, Hepatocellular ALKBH5-induced NEAT1 promoted cell proliferation and migration of HCC by sponging miR-214 in vitro, which may provide a potential therapeutic target for HCC. +genetics_knock down_promote 35357059 hsa-mir-217 Carcinoma, Renal Cell The inhibitory effects of circ_0008717 knockdown on RCC cell malignant behaviors were reversed by miR-217 inhibition or FBXO17 overexpression. CONCLUSIONS: Circ_0008717 aggravated the progression of RCC by activating FBXO17 through targeting miR-217, which provided a novel mechanism for circ_0008717 to participate in RCC progression. +transcription factor target 35356885 hsa-mir-100 Femur Head Necrosis 5p may be involved in the pathogenesis of NONFH by inhibiting the migration and osteogenic differentiation of rBMSCs. +circRNA target 35356749 hsa-mir-370 Colorectal Neoplasms CONCLUSION: In summary, our data highlight circRNA_101277 as a novel driver of CRC cell cisplatin resistance that functions by sequestering miR-370 and thereby enhancing IL-6 expression. These findings suggest that this circRNA_101277/miR-370/IL-6 axis may represent a critical axis of chemoresistance in CRC that can be targeted to diagnose and/or treat this cancer. +transcription factor target 35356421 hsa-mir-532 Carotid Artery Diseases Therefore, FBLN5 may play an important role in carotid atherosclerosis via hsa-mir-128 and hsa-mir3p as well as become an essential target for treatment. +transcription factor target 35356421 hsa-mir-128 Carotid Artery Diseases Therefore, FBLN5 may play an important role in carotid atherosclerosis via hsa-mir-128 and hsa-mir3p as well as become an essential target for treatment. +target gene 35356209 hsa-mir-216b Leukemia, Myeloid, Acute Daemonorops draco Blume Induces Apoptosis Against Acute Myeloid Leukemia Cells via Regulation of the miR-216b/c-Jun. +exosome 35356153 hsa-mir-200a Colorectal Neoplasms sEV-derived miR +exosome 35356153 hsa-mir-21 Colorectal Neoplasms sEV-derived miR +lncRNA target 35355424 hsa-mir-223 Breast Neoplasms 3p to regulate FABP7, thereby promoting proliferation, migration, invasion, and EMT of BC cells, and inhibiting cell apoptosis. +transcription factor target 35355364 hsa-mir-155 Pneumonia BMSCs may protect lung tissues from MV-induced injury, inhibit lung inflammation, promote autophagy through upregulating of miR5p. +genetics_knock down_suppress 35355231 hsa-mir-1179 Uterine Cervical Neoplasms In addition, circ_0000263 knockdown reduced CC tumor growth by miR-1179/ABL2 axis. +circulation_biomarker_diagnosis_down 35354913 hsa-mir-204 Arthritis, Rheumatoid Furthermore, Spearman correlation analysis indicated that plasma exosomal miR +other 35354890 hsa-mir-423 Myocardial Infarction, Acute 3p. +other 35354890 hsa-mir-146a Myocardial Infarction, Acute 3p. +target gene 35354791 hsa-mir-411 Stomach Neoplasms Hsa_circ_0007967 promotes gastric cancer proliferation through the miR-411-5p/MAML3 axis. +other 35354691 hsa-mir-181a Carcinoma, Non-Small-Cell Lung Two types of NSCLC cell lines, A549 and H69, and their CDDP-resistant cell lines, A549R and H68R, were used to investigate PD-L1 expression and microRNA mir-181a expression. Increased PD-L1 expression in acquired cisplatin-resistant lung cancer cells is dependent on mir-181a in NSCLC. +lncRNA target 35354145 hsa-mir-1913 Stomach Neoplasms In addition, miR-1913 targeted SETD1A, which was highly expressed in GC cells. +transcription factor target 35353669 hsa-mir-196b Glioma The miR-196b-5p altered the migration, proliferation, invasion, and apoptosis of glioma cells by regulating target genes, according to in vitro experiments.Conclusions: A miRNA-based individualized prognostic prediction model was constructed for glioma and miR-196b-5p was identified as a potential biomarker of glioma development. +genetics_overexpression_suppress 35353623 hsa-mir-32 Neuralgia 5p agomir or overexpression of miR +genetics_overexpression_suppress 35353623 hsa-mir-32 Trigeminal Neuralgia 5p agomir or overexpression of miR +genetics_overexpression_promote 35353623 hsa-mir-32 Hyperalgesia Conversely, miR5p overexpression in injured TG suppressed the increased expression of Cav3.2 and reversed mechanical allodynia. +epigenetics 35353623 hsa-mir-32 Cranial Nerve Injuries Nerve injury increased the methylated histone occupancy of binding sites for the transcription factor glucocorticoid receptor in the miR5p promoter region. +lncRNA target 35353555 hsa-mir-29b Osteoarthritis An aging-related miRNA, miR-29b-5p, was first found to be markedly down-regulated in OA cartilage, and their up-regulation suppressed the expression of matrix metalloproteinases and senescence-associated genes (P16(INK4a)/P21) via ten-eleven-translocation enzyme 1 (TET1). +circulation_biomarker_diagnosis_ns 35353360 hsa-mir-128 Asthma Our results revealed the serum of circ 001372 against inflammation in ovalbumin-induced asthma through Sirt1/NFAT5 by miRNA3p. +circulation_biomarker_diagnosis_ns 35353339 hsa-mir-183 Carotid Artery Diseases In serum samples from individuals with carotid atherosclerosis, Higher levels of miR +circRNA target 35353073 hsa-mir-149 Glomerulonephritis, Membranous Our results confirmed that circ_CDYL specifically targeted miR +lncRNA target 35353027 hsa-mir-631 Carcinoma, Non-Small-Cell Lung In brief, BMSC-Exo mediated E2F2 via delivering miR-631 to NSCLC cells to modulate the malignant behavior of NSCLC. +other 35352891 hsa-mir-494 Brain Ischemia CONCLUSION: MiR3p exacerbates brain injury and neuronal injury by regulating Bhlhe40 after I/R. +genetics_knock down_suppress 35352818 hsa-mir-200a Hepatitis B CONCLUSION: CircBACH1 knockdown had inhibitory effects on HBV replication and hepatoma progression, at least partly by modulating the miR-200a-3p/MAP3K2 axis. +genetics_knock down_suppress 35352818 hsa-mir-200a Carcinoma, Hepatocellular CONCLUSION: CircBACH1 knockdown had inhibitory effects on HBV replication and hepatoma progression, at least partly by modulating the miR-200a-3p/MAP3K2 axis. +lncRNA target 35352617 hsa-mir-495 Lymphoma, Large B-Cell, Diffuse However, inhibiting miR +lncRNA target 35352613 hsa-mir-502 Osteoarthritis CONCLUSION: Circ-PRKCH contributed to IL-1beta-treated cell phenotypic changes in chondrocytes via modulating miR +genetics_knock down_promote 35352610 hsa-mir-326 Arthritis, Rheumatoid FZD4 overexpression largely diminished miR-326 accumulation-mediated influences in TNF-alpha-treated RA-FLSs. +circRNA target 35352283 hsa-mir-520h Medulloblastoma circSKA3 expression in medulloblastoma tissues was negatively correlated with miR-520 h expression and positively correlated with CDK6 expression. circSKA3 facilitates medulloblastoma progression through miR-520 h/CDK6. +lncRNA target 35352023 hsa-mir-550a Diffuse Malignant Peritoneal Mesothelioma Through a gain-of-function approach using miRNA mimics in 3 DMPM cell lines, we demonstrated the tumor-suppressive role of miR-550a-3p. +transcription factor target 35351860 hsa-mir-381 Renal Insufficiency, Chronic Collectively, our findings proved that BMSC-Exo plays anti-calcification and anti-apoptosis roles in CKD by delivering enclosed miR3p, which directly targets NFAT5 mRNA, and leads to a better understanding of the mechanism of CKD-VC. +other 35351581 hsa-mir-655 Breast Neoplasms 3p axis in breast cancer were successively screened out, consisting of 11 lncRNAs, 17 circRNAs and 12 pseudogene-derived RNAs. +other 35351581 hsa-mir-186 Breast Neoplasms 3p axis in breast cancer were successively screened out, consisting of 11 lncRNAs, 17 circRNAs and 12 pseudogene-derived RNAs. +other 35351580 hsa-mir-10b Breast Neoplasms miR-10b-5p downregulation was partially responsible for PIEZO1 upregulation in breast cancer. +genetics_overexpression_promote 35351345 hsa-mir-206 Aortic Dissection CONCLUSION: SENCR overexpression suppressed VMSC proliferation and migration, maintained the contractile phenotype and suppressed aortic dilatation via the miR-206/myocardin axis. +other 35351157 hsa-mir-223 Asthma CONCLUSION: We identified a novel mechanism that lTSLP could promote inflammatory cytokines production by miR-223/VHL/HIF-1alpha pathway to upregulate aerobic glycolysis in airway epithelial cells in asthma. +lncRNA target 35351042 hsa-mir-20a Thyroid Cancer, Papillary Targeting CALML3-AS1/ miR-20a-5p/RBM38 axis may represent a novel therapeutic strategy in the treatment of PTC. +epigenetics 35350838 hsa-mir-195 Osteosarcoma The methylation of miR-195 was related to decreased miR-195, it might promote osteosarcoma. +other 35350836 hsa-mir-223 Pars Planitis 3p expression in IUA tissue samples. +genetics_overexpression_promote 35350778 hsa-mir-1972 Arthritis, Rheumatoid The blockage of miR-1972 significantly abrogated the angiogenesis stimulative ability of RA FLSs derived EVs in ECs, while the overexpression of miR-1972 reversed the effect in ECs. Collectively, RA FLSs derived EVs can promote ECs angiogenesis via miR-1972 targeted p53/mTOR signaling, targeting on RA FLSs derived EVs or miR-1972 provides a promising strategy for the treatment of patients with RA. +lncRNA target 35350667 hsa-mir-338 Carcinoma, Renal Cell 3p, regulated the proliferation, migration and invasion of ccRCC cells via the PI3K/Akt pathway; this finding not only enriches our understanding of the mechanism underlying ccRCC development, but also demonstrates a potential novel therapeutic target for this disease. +target gene 35350655 hsa-mir-519a Neuroblastoma Propofol inhibited oxidative stress and inflammation in MPP+-induced neuroblastoma cells by targeting the HOTAIRM1/miR-519a-3p axis +circulation_biomarker_prognosis_up 35350590 hsa-mir-143 Breast Neoplasms 5p in BC tissue of the GSE42072 and serum of the GSE41922 datasets by GEO chip analysis. +lncRNA target 35350588 hsa-mir-20a Carcinoma, Non-Small-Cell Lung It is suggested that miR-20a could be used as a biomarker and therapeutic target for the treatment of NSCLC. +lncRNA target 35350563 hsa-let-7c Carcinoma, Hepatocellular Then the most potential upstream microRNA contributing to PUDP was identified as let-7c-5p through expression analysis, correlation analysis, and survival analysis. +other 35350177 hsa-mir-139 Ischemia In conclusion, HA facilitates angiogenesis of MSCs-ECFCs, and this positive effect be associated with activation of the CD44/miR5p pathway, providing a promising strategy for improving severe limb ischemia. +lncRNA target 35349725 hsa-mir-28 Pulmonary Arterial Hypertension CONCLUSIONS: Silencing of LINC00963 ameliorates PAH via modulating miR +transcription factor target 35349487 hsa-mir-29c Food Addiction 3p inhibition promoted compulsion-like behavior and also enhanced food addiction vulnerability. +transcription factor target 35349487 hsa-mir-665 Food Addiction 3p inhibition promoted compulsion-like behavior and also enhanced food addiction vulnerability. +genetics_knock down_promote 35349390 hsa-mir-485 Colorectal Neoplasms Knockdown circPCLE1 refrained CRC proliferation, glucose consumption, lactic acid and pyruvate production, M2 macrophage markers (IL-10, MRC1), N-cadherin, Snail, reduced the proportion of CD206+ and CD168+ macrophages, but expedited M1 macrophage markers (TNF-alpha, IL-6) and E-cadherin, while descending miR +other 35349375 hsa-mir-146a Intervertebral disc disease Conclusion: Overall, SLC20A1-1, an IDD regulator, is involved in TNF-alpha-induced NPC apoptosis by sponging miR-146a-5p. +circulation_biomarker_diagnosis_ns 35349355 hsa-mir-7 Atherosclerosis Consistently, plasma levels of HDAC7-AS1 and MIR5p were found to be significantly associated individuals diagnosed with CHD. +other 35349097 hsa-mir-519a Fever We further explored its role in 1-methylphenylpyridinium (MPP(+))-damaged dopaminergic neurons (DAn) and the possible mechanism involving SNHG14, microRNA (miR)-519a-3p, and autophagy-related 10 (ATG10). +genetics_overexpression_suppress 35348974 hsa-mir-195 Breast Neoplasms miR-195 showed an IDC-specific downregulation, causing overexpression of CCNE1. +circulation_biomarker_diagnosis_ns 35348584 hsa-mir-99 Obesity, Abdominal Our study suggests that changes in circulating adipose-related miR +circulation_biomarker_diagnosis_ns 35348584 hsa-mir-100 Obesity, Abdominal Our study suggests that changes in circulating adipose-related miR +lncRNA target 35348441 hsa-mir-27a Cardiomegaly Inhibiting miR-27a-3p mitigated cardiac hypertrophy phenotype induced by Ang II. +genetics_overexpression_promote 35348293 hsa-mir-589 Liver Neoplasms Overexpressed miR +other 35348192 hsa-mir-423 Atrial Fibrillation In the AF cell model transfected with miR423, the expression of calcium handling proteins, including phosphorylated calmodulindependent protein kinase II, was reduced. The findings highlight the importance of calcium handling protein phosphorylation changes in fibrosisinduced AF and support miR423 detection in human urine as a potential novel approach of AF diagnosis. +lncRNA target 35347965 hsa-mir-34a Esophageal Neoplasms MicroRNA-34 a(miR-34 a) expression in esophageal carcinoma tissue is significantly lower than that in normal tissue. This study aims to investigate the inhibitory effect of PAMR on esophageal carcinoma cells, and the relationship between its inhibitory effect on PD-L1 expression and miR-34 a, which is expected to clarify the anti-tumor mechanism of PAMR. +circulation_biomarker_diagnosis_ns 35347894 hsa-mir-16 Adenocarcinoma of Lung OBJECTIVES: We aimed at investigating whether serum exosomal miR5p could be utilized as an immunotherapy biomarker in lung adenocarcinoma (LUAD) patients administered by programmed cell death ligand-1 (PD-L1) inhibitors, and to evaluate its functions in LUAD progression. +genetics_knock down_promote 35347818 hsa-mir-361 Stomach Neoplasms 3p, and its overexpression reversed the effects of miR +other 35347579 hsa-mir-7 Thyroid Nodule Differential expression of miRNA in wild-type nodules highlighted that two miRNAs, namely miR5p and miR-548ar-5p, were downregulated in FV-PTCs compared to FAs. +other 35347579 hsa-mir-548ar Thyroid Nodule Differential expression of miRNA in wild-type nodules highlighted that two miRNAs, namely miR5p and miR-548ar-5p, were downregulated in FV-PTCs compared to FAs. +circulation_biomarker_diagnosis_ns 35347537 hsa-mir-299 Multiple Sclerosis, Relapsing-Remitting Moreover, the results showed that there was an increased negative association between Tr1 frequency and plasma-OPN levels in RRMS patients in comparison to HCs and also, we found a moderate positive correlation between plasma-IL-10 and miR +tissue_expression_ns 35347477 hsa-mir-155 nonsyndromic congenital nail disorder 7 In vivo, exposing the developing vasculature to miR-155 promoted hypersprouting, thus phenocopying defects associated with Notch deficiency. +lncRNA target 35347427 hsa-mir-15b Diabetes Mellitus CONCLUSION: Kcnq1ot1 regulated beta-cell proliferation and insulin secretion via the miR-15b-5p/Ccnd1 and Ccnd2 axis, which is worthy of further investigation considering its potential in diabetes treatment. +circulation_biomarker_diagnosis_ns 35347106 hsa-mir-613 Osteosarcoma Besides, serum-EVs could transfer MIAT (EV-MIAT) into osteosarcoma cells, where it is competitively bound to miR-613 to elevate GPR158, thus promoting osteosarcoma cell proliferation and angiogenesis. +lncRNA target 35346892 hsa-mir-744 Cholangiocarcinoma TM4SF1-AS1 served as tumor promoter of CCA via modulating miR +other 35346790 hsa-mir-106a Alzheimer Disease 5p). +other 35346790 hsa-mir-204 Alzheimer Disease 5p). +other 35346790 hsa-let-7a Alzheimer Disease 5p). +other 35346790 hsa-mir-26a Alzheimer Disease 5p). +other 35346790 hsa-mir-144 Alzheimer Disease 5p). +other 35346790 hsa-mir-101 Alzheimer Disease 5p). +other 35346790 hsa-mir-9 Alzheimer Disease 5p). +other 35346790 hsa-mir-17 Alzheimer Disease 5p). +other 35346790 hsa-mir-26b Alzheimer Disease 5p). +other 35346790 hsa-mir-1 Alzheimer Disease 5p). +other 35346790 hsa-mir-20a Alzheimer Disease 5p). +other 35346790 hsa-mir-128 Alzheimer Disease 5p). +other 35346790 hsa-mir-34a Alzheimer Disease 5p). +other 35346790 hsa-mir-199a Alzheimer Disease 5p). +other 35346790 hsa-mir-16 Alzheimer Disease 5p). +other 35346790 hsa-mir-335 Alzheimer Disease 5p). +lncRNA target 35346765 hsa-mir-731 Heart Diseases In addition, mechanistic study demonstrated that Calcineurin/Nfatc3a signaling involved in miR-731 depletion induced abnormal cardiac function and developmental defects. CONCLUSION: MiR-731 regulates cardiac function and morphogenesis through Calcineurin/Nfatc3a signaling. +tissue_expression_ns 35346765 hsa-mir-731 Blind Loop Syndrome RESULTS: The depletion of miR-731 in zebrafish embryos caused the deficiency of cardiac development and function, which was associated with reduced heart rate, ventricular enlargement and heart looping disorder. +tissue_expression_ns 35346765 hsa-mir-731 Cardiomegaly The miR-731 morphants show pericardium enlargement, and many DEGs (differentially expressed genes) are enriched in 'Cardiac muscle contraction' and 'Calcium signaling pathway', implying that miR-731 plays a potential role in heart function and development. RESULTS: The depletion of miR-731 in zebrafish embryos caused the deficiency of cardiac development and function, which was associated with reduced heart rate, ventricular enlargement and heart looping disorder. +other 35346765 hsa-mir-731 Developmental Disabilities In addition, mechanistic study demonstrated that Calcineurin/Nfatc3a signaling involved in miR-731 depletion induced abnormal cardiac function and developmental defects. +exosome 35346324 hsa-mir-21 Esophageal Squamous Cell Carcinoma CONCLUSION: PABPC1 plays a critical role in ESCC malignant progression by interacting with eIF4G to regulate IFI27 mRNA stability and promote angiogenesis via exosomal miR5p/CXCL10. +circRNA target 35346268 hsa-mir-145 Osteosarcoma CONCLUSIONS: In conclusion, our study suggested that circ_0001017 may be a novel oncogenic factor during the progression and development of OS by targeting miR +genetics_overexpression_suppress 35346060 hsa-mir-1 Stomach Neoplasms Overexpressing miR +lncRNA target 35346026 hsa-mir-742 Myocardial Infarction CONCLUSION: CircRbms1 regulated the miR3p/FOXO1 axis to mediate hypoxia-induced cardiomyocyte injury, suggesting that circRbms1 might be an effective target for MI treatment. +genetics_overexpression_promote 35346026 hsa-mir-742 Cardiomyopathies 3p on hypoxia-induced cardiomyocyte injury was reversed by FOXO1 overexpression. +genetics_overexpression_promote 35345980 hsa-mir-326 Stomach Neoplasms Through rescue assays, inhibition of GC progression caused by LINC01270 suppression was found to be reversed by the application of miR-326 inhibitor or EFNA3 overexpression. +genetics_overexpression_promote 35345650 hsa-mir-1270 Breast Neoplasms miR-1270 overexpression suppressed proliferation and increased apoptotic rate of BCa cells. +genetics_overexpression_promote 35345511 hsa-mir-506 Carcinoma, Hepatocellular Furthermore, circSYPL1 overexpression could upregulate EZH2 expression, while miR +other 35345489 hsa-mir-885 Sepsis 5p/HMBOX1 axis in myocardial cell pyroptosis and provide new directions for the treatment of septic myocardial depression. +other 35345380 hsa-mir-27b Triple Negative Breast Neoplasms CONCLUSION: The results suggest the possible utilization of miR-27b and miR-451a expression levels as potential predictive risk markers for TNBC patients undergoing TAC chemotherapy. +other 35345380 hsa-mir-451a Triple Negative Breast Neoplasms CONCLUSION: The results suggest the possible utilization of miR-27b and miR-451a expression levels as potential predictive risk markers for TNBC patients undergoing TAC chemotherapy. +lncRNA target 35344194 hsa-mir-186 Reperfusion Injury, Cerebral Ischemia Therefore, these results suggest that FTX might ameliorate CI/RI by regulating the miR5p/MDM4 pathway, providing a new target for stroke impairment treatment. +lncRNA target 35344140 hsa-mir-28 Atherosclerosis miR-28 inhibitor reversed the effects of FENDRR silencing and reduced atherosclerotic plaque formation. FENDRR competed with TEAD1 to bind to miR-28, thereby reducing HUV-EC-C injury and atherosclerotic plaque formation. +lncRNA target 35343646 hsa-mir-362 Triple Negative Breast Neoplasms CONCLUSION: CircDHDDS expedited TNBC by swelling DDX5 via adapting miR +target gene 35343645 hsa-mir-1 Autoimmune Diseases miPEP31 downregulates miR-31 expression, enhances peripheral T(reg) induction, and dramatically suppresses experimental autoimmune encephalomyelitis. +genetics_knock down_promote 35343383 hsa-mir-488 Pancreatic Carcinoma ERBB2 knockdown in MIA PaCa-2 and PANC-1 cell lines suppressed, but miR-488 inhibition enhanced the cancer cell biological malignant behavior; the effects of miR-488 inhibition on pancreatic cancer cells were significantly reversed by ERBB2 knockdown. +genetics_overexpression_suppress 35343265 hsa-mir-1827 Carcinoma, Ductal, Breast In summary, our results indicated that overexpression of LINC00092 inhibited the development of IDC through modulating miR-1827/SFRP1 axis, suggesting new therapeutic targets to treat IDC. +transcription factor target 35343021 hsa-mir-130a Heart Diseases Recently we indicated that cardiac toxicity of Dox was due to upregulation of miR-130a and further suppressive effect on cardiac Ppargamma in vitro. +transcription factor target 35342753 hsa-mir-206b Thyroid Cancer, Papillary CONCLUSION: hsa-miR-206b might be involved in promoting TNM staging in PTC via targeting of LMX1B. +other 35342419 hsa-mir-224 Lung Neoplasms circNBPF10/miR-224 Axis Regulates PBX3 to Promote the Malignant Progression of Lung Cancer. +genetics_overexpression_suppress 35342412 hsa-mir-34c Carcinoma, Renal Cell The treatment of miR-34c-5p mimic attenuated the cell viability, proliferation, invasion, and migration of RCC cells, in which MMP2 overexpression restored the phenotypes. +other 35342411 hsa-mir-146b Carcinoma, Renal Cell Mechanically, LINC01535/miR-146b-5p/TRIM2 axis affected ccRCC progression by mediating the PI3K/Akt signaling. All in all, our observations suggest the LINC01535/miR-146b-5p/TRIM2 axis as a crucial role in ccRCC. +transcription factor target 35342408 hsa-mir-106b Carcinoma, Hepatocellular Herein, we found that miR-106b-5p is upregulated in both HCC patients' tumor tissues and HCC cell lines. Altogether, these data suggest that miR-106b-5p promotes cell proliferation and cell cycle and increases HCC cells' resistance to sorafenib through the BTG3/Bcl-xL/p27 signaling pathway. +other 35342404 hsa-mir-194 Gastric Precancerous Lesion 5p/FoxO3a pathway may provide an efficient strategy for the prevention and treatment of GPL. +genetics_overexpression_suppress 35342401 hsa-mir-23a Squamous Cell Carcinoma of Head and Neck Overexpression of miR-23a-3p inhibits the growth of oral cancer tumors. +genetics_overexpression_promote 35342398 hsa-mir-4731 Carcinoma, Non-Small-Cell Lung 5p mimic could remarkably restrain cell viability, invasion, and the translational expression level of vimentin and e-cadherin, with promoted cell apoptosis in NSCLC, which were notably reversed by RPLP0 overexpression. +other 35342355 hsa-mir-24 Ovarian Neoplasms This study first described a miR-23b-3p/miR3p-mediated positive feedback loop between CASC15 and SMAD3, which may reflect the underlying molecular mechanism of CASC15's oncogenic function in ovarian cancer. +other 35342355 hsa-mir-23b Ovarian Neoplasms This study first described a miR-23b-3p/miR3p-mediated positive feedback loop between CASC15 and SMAD3, which may reflect the underlying molecular mechanism of CASC15's oncogenic function in ovarian cancer. +transcription factor target 35342350 hsa-mir-200c Alzheimer Disease Conclusion and Implications: Our results strongly suggest that dysregulation of miR-200c expression contributes to the pathogenesis of AD, including cognitive impairment through hyperphosphorylated tau. +genetics_knock down_promote 35342341 hsa-mir-1236 Adenocarcinoma of Lung 3p was upregulated and ZEB1 expression reduced after circRAPGEF5 knockdown, and the proliferation, migration, and invasion of LAD cells was inhibited. +transcription factor target 35342340 hsa-mir-122 Liver Neoplasms In addition, we demonstrated that ILneutralizing strategies limit CSC occurrence and liver tumor progression through miR-122 restored-expression. +exosome 35342334 hsa-mir-197 Nasopharyngeal Carcinoma Interestingly, exosomal miR +other 35342284 hsa-mir-122 Adenocarcinoma of Lung CONCLUSIONS: Our data showed that hsa-mir-122 and a number of related genes may affect the prognosis of patients with lung adenocarcinoma by regulating the cytoskeleton, thus promoting tumor angiogenesis and the metastasis of tumor cells. +transcription factor target 35342027 hsa-mir-214 Glioblastoma However, use of an miR-214 inhibitor reversed the simvastatin suppressive effect on GBM cells. +genetics_overexpression_promote 35341975 hsa-mir-21 Primary Myelofibrosis Overexpressed PARP-1 reversed the effects of miR-21 on HASM cells, somewhat dependently on PARP +other 35341776 hsa-mir-205 Osteoporosis QPCR results indicated that KCNQ1OT1 and RICTOR were down-regulated, while miR5p was up-regulated in the osteoporotic patients, as compared with non-osteoporotic controls. +genetics_overexpression_promote 35341446 hsa-mir-132 Stomach Neoplasms 3p overexpression downregulated the protein levels of Wnt1, c-Myc, beta-catenin, proliferating cell nuclear antigen (PCNA) and N-cadherin, and upregulated E-cadherin expression in GC cells, which were all alleviated after KIF21B overexpression. +circRNA target 35341378 hsa-mir-149 Triple Negative Breast Neoplasms CONCLUSION: Circ_0041732 silencing suppressed TNBC cell tumor properties by decreasing FGF5 expression through miR +other 35341140 hsa-mir-27a Stomach Neoplasms pylori-positive patients, the frequency of miR-27a CT genotype at the rs895819 locus and its expression in the gastric cancer group were higher than those in other pathological groups. CONCLUSION: The C allele at miR-27a rs895819 locus may be an oncogene in gastric cancer. +lncRNA target 35340746 hsa-mir-145 Colorectal Neoplasms 5p negatively regulates the proliferation of CRC colo320 cells through downregulating msln gene expression in CRC colo320 cells. +genetics_knock down_promote 35340708 hsa-mir-665 Carcinoma, Non-Small-Cell Lung In addition, the GPX3 overexpression decreased the promoting effects of miR-665 upregulation on proliferation, migration, and invasion of NSCLC cells. +target gene 35340555 hsa-mir-29c Osteosarcoma TPX2 regulated by miR-29c-3p induces cell proliferation in osteosarcoma via the AKT signaling pathway. +transcription factor target 35340237 hsa-mir-375 Carcinoma, Hepatocellular In conclusion, this study suggests that miR3p functions as a tumor suppressor which could inhibit the progression of HCC via targeting YWHAZ and CDC42. +other 35340229 hsa-mir-93 Osteosarcoma 5p and the genes including LEF1, RUNX2, CSF1R, CDKN1A, and FBN1 act as key factors in the progression of osteosarcoma. +other 35340229 hsa-mir-34a Osteosarcoma 5p and the genes including LEF1, RUNX2, CSF1R, CDKN1A, and FBN1 act as key factors in the progression of osteosarcoma. +other 35340229 hsa-mir-154 Osteosarcoma 5p and the genes including LEF1, RUNX2, CSF1R, CDKN1A, and FBN1 act as key factors in the progression of osteosarcoma. +other 35340229 hsa-mir-22 Osteosarcoma 5p and the genes including LEF1, RUNX2, CSF1R, CDKN1A, and FBN1 act as key factors in the progression of osteosarcoma. +other 35340229 hsa-mir-485 Osteosarcoma 5p and the genes including LEF1, RUNX2, CSF1R, CDKN1A, and FBN1 act as key factors in the progression of osteosarcoma. +other 35340229 hsa-mir-9 Osteosarcoma 5p and the genes including LEF1, RUNX2, CSF1R, CDKN1A, and FBN1 act as key factors in the progression of osteosarcoma. +lncRNA target 35340210 hsa-mir-17 Intervertebral Disc Degeneration Altogether, our findings substantiated that downregulation of GAS5 reduced NPC apoptosis and promoted ECM remodeling, ultimately ameliorating the IVDD via miR +other 35340004 hsa-mir-342 Hypoxia-Ischemia, Brain 3p. +other 35340004 hsa-mir-30 Hypoxia-Ischemia, Brain 3p. +genetics_overexpression_promote 35339891 hsa-mir-499a Carcinoma, Renal Cell MiR-499a-5p overexpression suppressed RCC cell growth. +transcription factor target 35339759 hsa-mir-181a Retinoblastoma CONCLUSION: miR-181a-5p was significantly downregulated during the development of RB, and it suppressed the malignant behaviors of RB cells by targeting NRAS. +genetics_overexpression_promote 35339367 hsa-let-7i Granulomatosis with Polyangiitis Overexpression of let-7i inhibited KGN cell proliferation and decreased oestradiol production in an IMP2-dependent manner, providing a new molecular mechanism for PCOS. +genetics_overexpression_promote 35339367 hsa-let-7i Polycystic Ovary Syndrome Overexpression of let-7i inhibited KGN cell proliferation and decreased oestradiol production in an IMP2-dependent manner, providing a new molecular mechanism for PCOS. +other 35339120 hsa-mir-21 Amebiasis Out of 60 stool samples from amoebic patients, 17 (28.3%) were positive for microRNA-21 of E. +other 35339120 hsa-mir-22 Amebiasis Out of 60 stool sample from amoebic patients, 27 (45.0%) were positive for microRNA-22 of E. +other 35339026 hsa-mir-24 Pre-Eclampsia Expression levels of miR3p, was significantly elevated in preeclamptic placentas. +genetics_knock down_suppress 35338913 hsa-mir-1179 Polycystic Ovary Syndrome Taken together, this study revealed that circ_0043533 knockdown restrained the malignant progression of PCOS via targeting miR-1179. +lncRNA target 35338769 hsa-mir-370 Urinary Bladder Neoplasms To summarize, our study manifested that LINC01232 accelerates BC progression by targeting miR +transcription factor target 35338412 hsa-mir-326 Triple Negative Breast Neoplasms miR-326 was downregulated by increased hypoxia/HIF1A and ECM stiffness in chemoresistant tumors, leading to upregulation of ITGA5 and activation of the downstream FAK/Src signaling pathways. In chemoresistant tumors, hypoxia and resulting ECM stiffness repress the expression of the tumor suppressor miRNA, miR-326. +genetics_knock down_promote 35338123 hsa-mir-495 Pre-Eclampsia In conclusion, miR-495 knockdown can suppress p53/PUMA axis by targeting HDAC2 to enhance biological behaviors of trophoblast cells, which may prevent occurrence of PE. +other 35337919 hsa-mir-15b Depression Meanwhile, LBRD also improved the reduced GABA levels in depression by increasing the expression of lncRNA Neat1 and Malat1, as well as decreasing miRNA3p and miRNA-15b-5p. +other 35337919 hsa-mir-144 Depression Meanwhile, LBRD also improved the reduced GABA levels in depression by increasing the expression of lncRNA Neat1 and Malat1, as well as decreasing miRNA3p and miRNA-15b-5p. +other 35337805 hsa-mir-155 Carcinoma, Ductal, Breast We aim to study whether miRNA-155 (miR-155), miR-19a and miR-15a can predict inherent RS according to cellular RS in breast cancer (BC) patients. miR-155 and miR-19a discriminate between BC patients with and without cellular RS with area under the ROC curve 0.98 and 0.68. +other 35337805 hsa-mir-15a Carcinoma, Ductal, Breast We aim to study whether miRNA-155 (miR-155), miR-19a and miR-15a can predict inherent RS according to cellular RS in breast cancer (BC) patients. +circulation_biomarker_diagnosis_up 35337805 hsa-mir-19a Carcinoma, Ductal, Breast However, miR-19a showed upregulation in the blood of BC patients. +circulation_biomarker_prognosis_up 35337261 hsa-mir-27a Sepsis CONCLUSIONS: This study showed that circulating miR-27a level is correlated with oxidative stress and mortality in patients with sepsis, and may serve as a potential non-invasive molecular biomarker. +target gene 35337159 hsa-mir-342 Osteosarcoma Tumor Suppressive Role of miR-342-5p and miR-491-5p in Human Osteosarcoma Cells. +target gene 35337159 hsa-mir-491 Osteosarcoma Tumor Suppressive Role of miR-342-5p and miR-491-5p in Human Osteosarcoma Cells. +target gene 35337095 hsa-mir-486 Lung Neoplasms MiR-486-5p Targets CD133+ Lung Cancer Stem Cells through the p85/AKT Pathway. +transcription factor target 35336965 hsa-mir-192 Hypertrophy, Right Ventricular The miR-192 family and miR-181a were capable of suppressing the RV infection via targeting of the Wnt/beta-catenin pathway. +transcription factor target 35336965 hsa-mir-181a Hypertrophy, Right Ventricular The miR-192 family and miR-181a were capable of suppressing the RV infection via targeting of the Wnt/beta-catenin pathway. +other 35336723 hsa-mir-10b Ethylmalonic encephalopathy A total of 16,534 circRNAs and 271 miRNAs (125 novel miRNAs and 146 annotated miRNAs) were screened, and 214 differentially expressed (DE) circRNAs and 53 DE miRNAs were detected between the AN and SE lambs (i.e., novel_circ_0025840, novel_circ_0022779, novel_miR_107, miR-10b). +other 35336723 hsa-mir-107 Ethylmalonic encephalopathy A total of 16,534 circRNAs and 271 miRNAs (125 novel miRNAs and 146 annotated miRNAs) were screened, and 214 differentially expressed (DE) circRNAs and 53 DE miRNAs were detected between the AN and SE lambs (i.e., novel_circ_0025840, novel_circ_0022779, novel_miR_107, miR-10b). +other 35336723 hsa-mir-192 Ethylmalonic encephalopathy Then, a two-step machine learning approach combining Random Forest (RF) and XGBoost (candidates were first selected by RF and further assessed by XGBoost) was performed, which identified 44 circRNAs and 39 miRNAs as potential biomarkers (i.e., novel_circ_0000180, novel_circ_0000365, novel_miR_192, oar-miR3p) for E. +transcription factor target 35336043 hsa-mir-155 Pulmonary Fibrosis Overall, our data support the use of Chol-PCX as a carrier for anti-miR-155 for the combined therapeutic inhibition of CXCR4 and miR-155 expression as a way to improve fibrotic damage in the liver. +transcription factor target 35336043 hsa-mir-155 Liver Diseases, Alcoholic Overall, our data support the use of Chol-PCX as a carrier for anti-miR-155 for the combined therapeutic inhibition of CXCR4 and miR-155 expression as a way to improve fibrotic damage in the liver. +transcription factor target 35334501 hsa-mir-126 Pulpitis miR-126 may be a potential target to attenuate the inflammation of pulpitis. +circulation_biomarker_diagnosis_up 35334496 hsa-mir-21 Lung Neoplasms circ_SAR1A was located predominantly in the cytoplasm; it inhibited lung cancer growth in vitro and in vivo by sponging to miR +circulation_biomarker_prognosis_ns 35334494 hsa-mir-20 Sepsis CONCLUSIONS: The expression level of serum miR +circulation_biomarker_prognosis_ns 35334494 hsa-mir-20 Acute Kidney Injury CONCLUSIONS: The expression level of serum miR +circRNA target 35334414 hsa-mir-21 Carcinoma, Pancreatic Ductal Our study demonstrates that circ_0047744 acts as an anti-oncogene to inhibit PDAC metastasis by regulating the miR-21/SOCS5 axis, indicating that circ_0047744 may be a potential novel therapeutic target for PDAC patients. +transcription factor target 35334283 hsa-mir-126 Mesothelioma, Malignant Autophagy is involved in these processes; miR-126 accumulation induced a protective autophagy and the inhibition of this process by GW4869 generates a metabolic crisis that promotes necroptosis, which was associated with PARP-1 over-expression and cyt-c and AIF release. +exosome 35334101 hsa-mir-1323 Uterine Cervical Neoplasms Functional assays indicated that miR-1323 was transferred by cancer-associated fibroblasts-secreted (CAFs-secreted) exosomes and miR-1323 downregulation suppressed cell proliferation, migration, invasion, and increased cell radiosensitivity in CCa. +lncRNA target 35334070 hsa-mir-4652 Carcinoma, Non-Small-Cell Lung 5p targeted RND1 to modulate cell adhesion and the progression of LUSC cells. +genetics_knock down_suppress 35334040 hsa-mir-627 Glioma CONCLUSION: Circ_RPPH1 knockdown inhibited glioma tumorigenesis by downregulating SDC1 by binding to miR +genetics_knock down_suppress 35334040 hsa-mir-663a Glioma CONCLUSION: Circ_RPPH1 knockdown inhibited glioma tumorigenesis by downregulating SDC1 by binding to miR +other 35333695 hsa-mir-23a Leukemia, Myelogenous, Chronic, BCR-ABL Positive Restoration of miR-23a by chidamide may therefore have a therapeutic effect in controlling the sensitivity of CML cells to imatinib. +genetics_knock down_suppress 35333693 hsa-mir-1287 Carcinoma, Non-Small-Cell Lung Circ_0008717 knockdown inhibited NSCLC tumorigenesis via miR +genetics_overexpression_promote 35332852 hsa-mir-125a Uterine Cervical Neoplasms Functionally, the overexpression of miR-125a greatly prevented the proliferation, migration and invasion of CSCC cells, and the inhibition of miR-125a expression strongly enhanced these behaviors in CSCC cells. +lncRNA target 35332770 hsa-mir-451a Squamous Cell Carcinoma of Head and Neck BACKGROUND: The miR-144/451a cluster acts as a tumor suppressor in various tumors by synergistically inhibiting the proliferation, migration, and invasion of oral squamous cell carcinoma (OSCC). +lncRNA target 35332770 hsa-mir-144 Squamous Cell Carcinoma of Head and Neck BACKGROUND: The miR-144/451a cluster acts as a tumor suppressor in various tumors by synergistically inhibiting the proliferation, migration, and invasion of oral squamous cell carcinoma (OSCC). +genetics_overexpression_promote 35332577 hsa-mir-144 Rectal Neoplasms CONCLUSIONS: Our data suggest that overexpression of miR-144/miR-451 cluster promotes LVI via repression of PTEN and p19 in rectal NET-G1 cells. miR-144/451 cluster may be a novel biomarker for predicting invasion/metastasis in rectal NET-G1. +lncRNA target 35332412 hsa-mir-762 Osteosarcoma CONCLUSION: In this study, LncRNA BACE1-AS regulates proliferation, migration and invasion of osteosarcoma cells by miR-762/SOX7 axis, implying that LncRNA BACE1-AS is a potential target for osteosarcoma therapy. +tissue_expression_ns 35332065 hsa-mir-140 Craniofacial Abnormalities miR-140 deficiency causes dwarfism and craniofacial deformity. +tissue_expression_ns 35332065 hsa-mir-140 Dwarfism miR-140 deficiency causes dwarfism and craniofacial deformity. +tissue_expression_ns 35332065 hsa-mir-140 Warburg micro syndrome 1 miR-140 deficiency causes dwarfism and craniofacial deformity. +lncRNA target 35331106 hsa-mir-199b Wounds and Injuries CONCLUSION: The miR-199b-5p-dependent regulation of AKAP1/DRP1 is required to inhibit hyperlipidemia- induced mitochondrial fission and endothelial injury and may be a promising therapeutic target for AS. +lncRNA target 35331106 hsa-mir-199b Angelman Syndrome CONCLUSION: The miR-199b-5p-dependent regulation of AKAP1/DRP1 is required to inhibit hyperlipidemia- induced mitochondrial fission and endothelial injury and may be a promising therapeutic target for AS. +lncRNA target 35331106 hsa-mir-199b Hyperlipidemias CONCLUSION: The miR-199b-5p-dependent regulation of AKAP1/DRP1 is required to inhibit hyperlipidemia- induced mitochondrial fission and endothelial injury and may be a promising therapeutic target for AS. +genetics_overexpression_promote 35330997 hsa-mir-520d Osteosarcoma miR-520d-3p overexpression suppressed the proliferation, migration, invasion, VM, and promotes the adhesion of OS cells in vitro. +lncRNA target 35330559 hsa-mir-182 Diabetes, Gestational 3p effectively alleviated the development of GDM through INSR1, suggesting a potential therapeutic strategy for GDM. +other 35330543 hsa-mir-196a Liver Neoplasms BACKGROUND: MiR-196a is particularly noticeable in the development of liver cancer. +genetics_knock down_promote 35329958 hsa-mir-22 Diabetic Neuropathies Following a q-PCR-based analysis of total plasma microRNAs, we found that miR-92b-3p (p = 0.008) was significantly downregulated, while miR3p (p = 0.0001) was significantly upregulated in T2DM patients with corneal nerve loss. +genetics_knock down_promote 35329958 hsa-mir-92b Diabetic Neuropathies Following a q-PCR-based analysis of total plasma microRNAs, we found that miR-92b-3p (p = 0.008) was significantly downregulated, while miR3p (p = 0.0001) was significantly upregulated in T2DM patients with corneal nerve loss. +other 35328807 hsa-mir-451a Ischemic Stroke Moreover, in samples collected one month following stroke, we found sustained upregulation of hsa-miR-451a and downregulation of another 5 miRNAs. +other 35328750 hsa-mir-21 Lung Neoplasms Data show the developed MB approach potential for miR5p detection in PBMCs from clinical samples towards NSCLC. +exosome 35328425 hsa-mir-21 Carcinoma, Renal Cell Taken together, our results demonstrate that M2-Exos carries miR +other 35328424 hsa-mir-148a Tuberculosis Our data indicate that miR-148a may protect against tuberculous pleural fibrosis by regulating NOX4 and POLDIP2. +other 35328400 hsa-mir-183 Obesity 5p plays a crucial role in the pathogenesis of hepatic insulin resistance in the background of obesity. +other 35328400 hsa-mir-183 Insulin Resistance 5p plays a crucial role in the pathogenesis of hepatic insulin resistance in the background of obesity. +other 35328383 hsa-mir-21 Lung Neoplasms To demonstrate its usefulness, we chose miR-21, which is upregulated and implicated in lung cancer. We constructed a miR-21 sponge and inserted it into a vector that facilitates circular RNA production (Circ-21) to study its effect on growth, colony formation, and migration in lung cancer cell lines and multicellular tumor spheroids (MTS). +other 35328346 hsa-mir-96 Prostatic Neoplasms 5p, IGFBP2, HIF1A, PIK3CB and MTOR were upregulated in AA PCa versus EA PCa cells. +other 35328346 hsa-mir-34a Prostatic Neoplasms 5p, IGFBP2, HIF1A, PIK3CB and MTOR were upregulated in AA PCa versus EA PCa cells. +other 35328346 hsa-mir-99b Prostatic Neoplasms 5p, IGFBP2, HIF1A, PIK3CB and MTOR were upregulated in AA PCa versus EA PCa cells. +lncRNA target 35328298 hsa-mir-126 Breast Neoplasms Overall, our study suggests that miR-126 might play a tumor suppressor role in ER+ BC. +other 35328182 hsa-let-7a Lymphoma, Non-Hodgkin We demonstrated that expression levels of miRNA-124, miRNA-221, and miRNA-15a are statistically significantly downregulated, while the expression level of let-7a is statistically significantly upregulated more than 2-fold in BM in NHL compared to those in AL and NCBD. ROC analysis revealed that let-7a/miRNA-124 is a highly sensitive and specific biomarker for a differential diagnosis of BM changes in NHL from those in AL and NCBD. +other 35328182 hsa-mir-124 Lymphoma, Non-Hodgkin We demonstrated that expression levels of miRNA-124, miRNA-221, and miRNA-15a are statistically significantly downregulated, while the expression level of let-7a is statistically significantly upregulated more than 2-fold in BM in NHL compared to those in AL and NCBD. ROC analysis revealed that let-7a/miRNA-124 is a highly sensitive and specific biomarker for a differential diagnosis of BM changes in NHL from those in AL and NCBD. +circulation_biomarker_diagnosis_ns 35328059 hsa-mir-17 Alopecia Areata We evaluated, for the first time, the miR92a-1 cluster host gene (MIR17HG) expression in peripheral blood of 248 unrelated alopecia areata (AA) patients compared to 244 matched controls using Real-Time qPCR. +other 35328023 hsa-mir-185 Chronic Disease Emerging evidence implicates miR5p in chronic inflammation diseases. +other 35327987 hsa-mir-27b Sleep Apnea, Obstructive miR-27b-3p decreased in OSAs and ESCs. +lncRNA target 35327612 hsa-mir-34a Carcinoma, Non-Small-Cell Lung Furthermore, miR-34a induces senescence and apoptosis in breast, glioma, cervical cancer including NSCLC by targeting Myc. +other 35327520 hsa-mir-181a Fetal Growth Retardation 3p, miR-20a-5p, miR-146a-5p, and miR-181a-5p) was able to identify 75.68% SGA pregnancies at 10.0% FPR in early stages of gestation. +other 35327520 hsa-mir-20a Fetal Growth Retardation 3p, miR-20a-5p, miR-146a-5p, and miR-181a-5p) was able to identify 75.68% SGA pregnancies at 10.0% FPR in early stages of gestation. +other 35327520 hsa-mir-145 Pre-Eclampsia 3p) was able to identify 42.68% FGR pregnancies at 10.0% FPR in early stages of gestation. +other 35327520 hsa-mir-20a Pre-Eclampsia 3p, miR-20a-5p, miR-146a-5p, and miR-181a-5p) was able to identify 75.68% SGA pregnancies at 10.0% FPR in early stages of gestation. +other 35327520 hsa-mir-574 Pre-Eclampsia 3p) was able to identify 42.68% FGR pregnancies at 10.0% FPR in early stages of gestation. +other 35327520 hsa-mir-146a Pre-Eclampsia 3p, miR-20a-5p, miR-146a-5p, and miR-181a-5p) was able to identify 75.68% SGA pregnancies at 10.0% FPR in early stages of gestation. +other 35327520 hsa-mir-342 Cardiovascular Diseases 3p) was able to identify 42.68% FGR pregnancies at 10.0% FPR in early stages of gestation. +other 35327520 hsa-mir-146a Fetal Growth Retardation 3p, miR-20a-5p, miR-146a-5p, and miR-181a-5p) was able to identify 75.68% SGA pregnancies at 10.0% FPR in early stages of gestation. +other 35327520 hsa-mir-145 Fetal Growth Retardation 3p) was able to identify 42.68% FGR pregnancies at 10.0% FPR in early stages of gestation. +other 35327520 hsa-mir-20a Cardiovascular Diseases 3p, miR-20a-5p, miR-146a-5p, and miR-181a-5p) was able to identify 75.68% SGA pregnancies at 10.0% FPR in early stages of gestation. +other 35327520 hsa-mir-146a Cardiovascular Diseases 3p, miR-20a-5p, miR-146a-5p, and miR-181a-5p) was able to identify 75.68% SGA pregnancies at 10.0% FPR in early stages of gestation. +other 35327520 hsa-mir-181a Pre-Eclampsia 3p, miR-20a-5p, miR-146a-5p, and miR-181a-5p) was able to identify 75.68% SGA pregnancies at 10.0% FPR in early stages of gestation. +other 35327520 hsa-mir-181a Cardiovascular Diseases 3p, miR-20a-5p, miR-146a-5p, and miR-181a-5p) was able to identify 75.68% SGA pregnancies at 10.0% FPR in early stages of gestation. +other 35327520 hsa-mir-145 Cardiovascular Diseases 3p) was able to identify 42.68% FGR pregnancies at 10.0% FPR in early stages of gestation. +other 35327520 hsa-mir-342 Pre-Eclampsia 3p) was able to identify 42.68% FGR pregnancies at 10.0% FPR in early stages of gestation. +other 35327520 hsa-mir-342 Fetal Growth Retardation 3p) was able to identify 42.68% FGR pregnancies at 10.0% FPR in early stages of gestation. +other 35327520 hsa-mir-574 Cardiovascular Diseases 3p) was able to identify 42.68% FGR pregnancies at 10.0% FPR in early stages of gestation. +other 35327520 hsa-mir-574 Fetal Growth Retardation 3p) was able to identify 42.68% FGR pregnancies at 10.0% FPR in early stages of gestation. +lncRNA target 35327465 hsa-mir-133b Squamous Cell Carcinoma of Head and Neck 3p, miR-206, miR-133a-3p, and miR-133b were significantly suppressed in cancer specimens. +lncRNA target 35327465 hsa-mir-1 Squamous Cell Carcinoma of Head and Neck 3p, miR-206, miR-133a-3p, and miR-133b were significantly suppressed in cancer specimens. +lncRNA target 35327465 hsa-mir-133a Squamous Cell Carcinoma of Head and Neck 3p, miR-206, miR-133a-3p, and miR-133b were significantly suppressed in cancer specimens. +lncRNA target 35327465 hsa-mir-206 Squamous Cell Carcinoma of Head and Neck 3p, miR-206, miR-133a-3p, and miR-133b were significantly suppressed in cancer specimens. +other 35327461 hsa-mir-7 Melanoma Acidification of metastatic melanoma environment made EVs more prooncogenic with increased expression of prooncogenic mi221 RNA, stemless factor CD133, and pro-migration factor SNAI1, as well as with downregulated antitumor mir7 RNA. +lncRNA target 35327430 hsa-let-7d Pulmonary Arterial Hypertension RESULTS: Our study found: 1) miR-26 and miR-let-7d levels were significantly lower in SSc-PAH (n = 12) versus SSc without PAH (SSc-noPAH) patients (n = 25); 2) a positive correlation between miR-26 and miR-let-7d and complement-C3; 3) GO-annotations of genes that are miR-26/miR-let-7d targets and that are expressed in myofibroblast cells, suggesting that these miRNAs regulate the TGF-beta-pathway; 4) reduced levels of both miRNAs accompanied fibroblast differentiation to myofibroblasts, while macitentan (endothelin receptor-antagonist) increased the levels. +lncRNA target 35327430 hsa-mir-26 Scleroderma, Systemic RESULTS: Our study found: 1) miR-26 and miR-let-7d levels were significantly lower in SSc-PAH (n = 12) versus SSc without PAH (SSc-noPAH) patients (n = 25); 2) a positive correlation between miR-26 and miR-let-7d and complement-C3; 3) GO-annotations of genes that are miR-26/miR-let-7d targets and that are expressed in myofibroblast cells, suggesting that these miRNAs regulate the TGF-beta-pathway; 4) reduced levels of both miRNAs accompanied fibroblast differentiation to myofibroblasts, while macitentan (endothelin receptor-antagonist) increased the levels. +lncRNA target 35327430 hsa-mir-26 Pulmonary Arterial Hypertension RESULTS: Our study found: 1) miR-26 and miR-let-7d levels were significantly lower in SSc-PAH (n = 12) versus SSc without PAH (SSc-noPAH) patients (n = 25); 2) a positive correlation between miR-26 and miR-let-7d and complement-C3; 3) GO-annotations of genes that are miR-26/miR-let-7d targets and that are expressed in myofibroblast cells, suggesting that these miRNAs regulate the TGF-beta-pathway; 4) reduced levels of both miRNAs accompanied fibroblast differentiation to myofibroblasts, while macitentan (endothelin receptor-antagonist) increased the levels. +lncRNA target 35327430 hsa-let-7d Scleroderma, Systemic RESULTS: Our study found: 1) miR-26 and miR-let-7d levels were significantly lower in SSc-PAH (n = 12) versus SSc without PAH (SSc-noPAH) patients (n = 25); 2) a positive correlation between miR-26 and miR-let-7d and complement-C3; 3) GO-annotations of genes that are miR-26/miR-let-7d targets and that are expressed in myofibroblast cells, suggesting that these miRNAs regulate the TGF-beta-pathway; 4) reduced levels of both miRNAs accompanied fibroblast differentiation to myofibroblasts, while macitentan (endothelin receptor-antagonist) increased the levels. +circulation_biomarker_diagnosis_ns 35327332 hsa-mir-4454 Pediatric Obesity To have a more complete insight, the expression of some circulating miRNAs that are linked to obesity (miR-33a, miR-223, miR-142, miR-199a, miR-181a, and miR-4454) were also analyzed. +circulation_biomarker_diagnosis_ns 35327332 hsa-mir-181a Pediatric Obesity To have a more complete insight, the expression of some circulating miRNAs that are linked to obesity (miR-33a, miR-223, miR-142, miR-199a, miR-181a, and miR-4454) were also analyzed. Circulating miRNAs showed a tendency to increase in obese subjects, except for miR-181a expression. +circulation_biomarker_diagnosis_ns 35327332 hsa-mir-142 Pediatric Obesity To have a more complete insight, the expression of some circulating miRNAs that are linked to obesity (miR-33a, miR-223, miR-142, miR-199a, miR-181a, and miR-4454) were also analyzed. +circulation_biomarker_diagnosis_ns 35327332 hsa-mir-199a Pediatric Obesity To have a more complete insight, the expression of some circulating miRNAs that are linked to obesity (miR-33a, miR-223, miR-142, miR-199a, miR-181a, and miR-4454) were also analyzed. +circulation_biomarker_diagnosis_ns 35327332 hsa-mir-223 Pediatric Obesity To have a more complete insight, the expression of some circulating miRNAs that are linked to obesity (miR-33a, miR-223, miR-142, miR-199a, miR-181a, and miR-4454) were also analyzed. +circulation_biomarker_diagnosis_ns 35327332 hsa-mir-33a Pediatric Obesity To have a more complete insight, the expression of some circulating miRNAs that are linked to obesity (miR-33a, miR-223, miR-142, miR-199a, miR-181a, and miR-4454) were also analyzed. +other 35326280 hsa-mir-155 Glioma A significant correlation was found between the miR-155 concentration and the level of PD-L1 expression in p-HGG tumor tissue. +transcription factor target 35325806 hsa-mir-33a Abortion, Habitual MiR-33a, miR-33b, and miR-181a were reduced in the placenta from patients with RPL, which were identified to repress S1PR1 expression by targeting the 3'UTR. +transcription factor target 35325806 hsa-mir-181a Abortion, Habitual MiR-33a, miR-33b, and miR-181a were reduced in the placenta from patients with RPL, which were identified to repress S1PR1 expression by targeting the 3'UTR. +lncRNA target 35325570 hsa-mir-765 Breast Neoplasms In this study, we prove that LINC00982 regulates the growth and development of BC through STAT3/NF-kappaB signal pathway, mediated by the miR-765/DPF3 axis. +lncRNA target 35325441 hsa-mir-365a Inflammation In conclusion, lncRNA NEAT1 was involved in AP progression by sponging miR-365a-3p and may thus be a novel target for treating patients with AP. +lncRNA target 35325441 hsa-mir-365a Pancreatitis In conclusion, lncRNA NEAT1 was involved in AP progression by sponging miR-365a-3p and may thus be a novel target for treating patients with AP. +genetics_knock down_promote 35324917 hsa-mir-21 De Lange Syndrome The miR-21 inhibitor decreased IL-10 levels in culture supernatants from splenic leukocytes in the CanL group. +other 35324773 hsa-mir-221 Carcinoma, Pancreatic Ductal Specifically, following NiCl(2) exposure to PDAC cells, the expression levels of miR-221 and miR-155 were significantly upregulated, while the expression levels of miR-126 were significantly decreased. +other 35324773 hsa-mir-126 Carcinoma, Pancreatic Ductal Specifically, following NiCl(2) exposure to PDAC cells, the expression levels of miR-221 and miR-155 were significantly upregulated, while the expression levels of miR-126 were significantly decreased. +other 35324773 hsa-mir-155 Carcinoma, Pancreatic Ductal Specifically, following NiCl(2) exposure to PDAC cells, the expression levels of miR-221 and miR-155 were significantly upregulated, while the expression levels of miR-126 were significantly decreased. +lncRNA target 35324533 hsa-mir-30 Thyroid Neoplasms circ_0058063 can act as a carcinogen in cases with TC via the miR +lncRNA target 35324527 hsa-mir-657 Retinoblastoma miR-657 enhanced the retinoblastoma tumorigenesis by directly inhibiting PPARA expression, suggesting that PPARA targeting by miR-657 facilitates retinoblastoma development by enhancing cell growth. +lncRNA target 35324526 hsa-mir-361 Pituitary Neoplasms 3p-mediated cell invasion, proliferation and apoptosis in BBOX1-AS1-dysregulated pituitary adenoma cells in rescue tests. +lncRNA target 35324519 hsa-mir-429 Thyroid Cancer, Papillary Downregulation of RNF185-AS1 may suppress PTC progression through functioning as a sponge of miR-429 to hinder the expression of LRP4. The RNF185-AS1/miR-429/LRP4 axis will lay the groundwork for future therapeutic strategies in PTC. +other 35324518 hsa-mir-485 Carcinoma, Non-Small-Cell Lung CONCLUSION: CircFOXK2 sponged miR5p to stimulate PD-L1 and expedited NSCLC development. +genetics_overexpression_suppress 35324517 hsa-mir-1207 Colorectal Neoplasms Overexpression of miR +lncRNA target 35322864 hsa-mir-205 Intervertebral disc disease These results suggested that targeting LINC00284 to rescue miR2053p expression may be a potential method for IDD management. +genetics_overexpression_promote 35322757 hsa-mir-29a Non-alcoholic Fatty Liver Disease Moreover, GAS5 overexpression enhanced NOTCH2 levels in liver cells and promoted NAFLD progression by sponging miR-29a-3p in vivo. +lncRNA target 35322738 hsa-mir-21 Inflammation Taken together, we can conclude that MEG3 mediates inflammation, oxidative stress and apoptosis in TNF-alpha-treated ICC via the miR-21/IKKB-NF-kappaB axis. +genetics_knock down_promote 35322736 hsa-mir-142 Osteoarthritis 5p, and circ_0005526 knockdown suppressed IL-1beta-induced OA progression through upregulating miR +lncRNA target 35322735 hsa-mir-627 Hepatitis B Together, our data suggest that HMMR-AS1 regulates HBV-HCC progression via miR +lncRNA target 35322735 hsa-mir-627 Carcinoma, Hepatocellular Together, our data suggest that HMMR-AS1 regulates HBV-HCC progression via miR +genetics_knock down_promote 35322553 hsa-mir-29b Ischemic Stroke CONCLUSIONS: Our findings confirm that H19 promotes leukocyte inflammation by targeting the miR-29b/C1QTNF6 axis in cerebral ischemic injury. +lncRNA target 35322532 hsa-mir-126 Adenocarcinoma of Lung 5p downregulated EZH2 to facilitate the sensitivity of lung adenocarcinoma cells to radiotherapy via KLF2/BIRC5. +genetics_overexpression_suppress 35322290 hsa-mir-29b Atrial Fibrillation TGFbetaRIota overexpression overcame the improving effect of miR-29b overexpression on AF. +genetics_overexpression_suppress 35322290 hsa-mir-29b Fibrosis, Atrial TGFbetaRIota overexpression overcame the improving effect of miR-29b overexpression on AF. +genetics_knock down_promote 35322289 hsa-mir-579 Esophageal Squamous Cell Carcinoma Furthermore, the inhibitory effects of circ_0001093 knockdown on the invasion, migration and glutamine metabolism were partly rescued by miR +lncRNA target 35321971 hsa-mir-9a Arthritis, Rheumatoid We further showed that miR-9a-5p specifically interacts with KLF7 to negatively regulate the expression of KLF7 in RA-FLSs. Taken together, our results demonstrated that KLF7 which targeted by miR-9a-5p might participate in the pathogenesis of RA by promoting cell proliferation, pro-inflammatory cytokine release and MMP expression through the activation of NF-kappaB and JNK pathways in RA-FLSs. +other 35321689 hsa-mir-335 Urinary Bladder Neoplasms 5p. +circulation_biomarker_diagnosis_down 35321519 hsa-mir-485 Osteoporosis The plasma expression levels of miR +circulation_biomarker_diagnosis_down 35321519 hsa-mir-491 Osteoporosis The plasma expression levels of miR +target gene 35321435 hsa-mir-4291 Uterine Cervical Neoplasms Circular RNA circLMO1 Suppresses Cervical Cancer Growth and Metastasis by Triggering miR-4291/ACSL4-Mediated Ferroptosis. +target gene 35321434 hsa-mir-192 Prostatic Neoplasms BK002 Induces miR-192-5p-Mediated Apoptosis in Castration-Resistant Prostate Cancer Cells via Modulation of PI3K/CHOP. +circulation_biomarker_diagnosis_up 35321390 hsa-mir-122 Hepatitis B, Chronic Finally, it was found that the miR-122 serum concentration correlated with HBV DNA and serum ALT (p=0.001). +transcription factor target 35321102 hsa-mir-194 Cardiotoxicity CONCLUSION: Our findings revealed that silencing miR5p could alleviate DOX-induced cardiotoxicity via PAK2 and XBP1s in vitro and in vivo. +other 35321102 hsa-mir-194 Heart Diseases Silencing of miR5p also improved DOX-induced cardiac dysfunction. +other 35321102 hsa-mir-194 Myocardial Infarction MiR5p has been reported significantly upregulated in patients with myocardial infarction; however, its role in myocardial diseases is still unclear. +other 35321102 hsa-mir-194 Cardiomyopathies MiR5p has been reported significantly upregulated in patients with myocardial infarction; however, its role in myocardial diseases is still unclear. +exosome 35321026 hsa-mir-761 Endometriosis CONCLUSION: Exosomal HOTAIR promoted the progression and angiogenesis of endometriosis by regulating the miR-761/HDAC1 axis and activating STAT3-mediated inflammation in vitro and in vivo, which may provide promising treatment for endometriosis. +lncRNA target 35321017 hsa-mir-1251 Hirschsprung Disease The novel RMST/SOX2/miR-1251/AHNAK axis provided potential targets for the diagnosis and treatment of HSCR during embryonic stage. +circRNA target 35320976 hsa-mir-589 Stomach Neoplasms We also showed that circCASP9 can regulate the growth and metastasis of GC via the miR +lncRNA target 35320950 hsa-mir-1271 Carcinoma, Renal Cell In addition, we explored the relationship between the crucial genes and TIICs via coexpression analysis, which revealed that the interactions between MALAT1, miR +other 35320929 hsa-mir-101 Thyroid Cancer, Papillary 3p axis in the setting of LUAD and suggests diagnostic and therapeutic biomarkers potentially useful in the clinical management of this illness. +other 35320929 hsa-mir-101 Adenocarcinoma of Lung 3p axis in the setting of LUAD and suggests diagnostic and therapeutic biomarkers potentially useful in the clinical management of this illness. +other 35320579 hsa-mir-106b Infertility, Male In conclusion, our findings showed that miR-106b-5p enhances the proliferative potential of SSCs, making it a substantial factor for therapeutic strategies of male infertility. +genetics_knock down_promote 35320491 hsa-mir-338 Siderosis 3p inhibitor and SLC1A5 overexpression vectors were delivered into the RPE cells, and the following gain- and loss-of-function experiments validated that both miR +other 35320453 hsa-mir-125b Breast Neoplasms MiR-125b-5p/TPD52 Axis Affects Proliferation, Migration and Invasion of Breast Cancer Cells. +exosome 35319370 hsa-mir-210 Brain Ischemia CONCLUSION: EA treatment could activate the HIF-1alpha/VEGF/Notch 1 signal pathway to facilitate angiogenesis after ischemic stroke via exosomal miR-210. +genetics_knock down_promote 35319228 hsa-mir-155 Inflammatory Bowel Diseases 5p inhibitors, whereas knockdown of GATA3 by RNA interference enhanced IBDV growth, and this enhancement could be blocked with gga-miR +lncRNA target 35319228 hsa-mir-155 Fused Teeth 5p) enhanced IFN-beta expression and suppressed the replication of infectious burse disease virus (IBDV), a double-stranded RNA (dsRNA) virus causing infectious burse disease in chickens. +lncRNA target 35319228 hsa-mir-155 Bird Diseases 5p) enhanced IFN-beta expression and suppressed the replication of infectious burse disease virus (IBDV), a double-stranded RNA (dsRNA) virus causing infectious burse disease in chickens. +target gene 35319228 hsa-mir-155 Immune System Diseases IMPORTANCE Gga-miR5p acts as an important antivirus factor against IBDV infection, which causes a severe immunosuppressive disease in chicken. +lncRNA target 35319228 hsa-mir-155 Bursitis 5p) enhanced IFN-beta expression and suppressed the replication of infectious burse disease virus (IBDV), a double-stranded RNA (dsRNA) virus causing infectious burse disease in chickens. +lncRNA target 35319018 hsa-mir-16 Breast Neoplasms We found that tumor hypoxia can transcriptionally induce HIF1alpha and post-transcriptionally inhibit the expression of miR5p to promote YTHDF1 expression, which could sequentially enhance tumor glycolysis by upregulating PKM2 and eventually increase the tumorigenesis and metastasis potential of breast cancer cells. +transcription factor target 35319011 hsa-mir-23a Colorectal Neoplasms MiR-323a-3p promotes CRC cells apoptosis by targeting ErbB3-phosphoinositide 3-kinases (PI3K)/PKB protein kinase (Akt)/glycogen synthase kinase 3 beta (GSK3beta)/EGFR-extracellular regulated MAP kinase (Erk1/2) signaling directly. MiR-323a-3p reverses ErbB3/EGFR signaling activation in gefitinib-resistant CRC cell lines and blocks acquired gefitinib resistance. +circulation_biomarker_diagnosis_ns 35318442 hsa-mir-409 Neuroblastoma MiRNA5p interacted with HNF4A-AS1 to facilitate sPEP1 translation via recruiting eukaryotic translation initiation factor 3 subunit G, while sPEP1 repressed serum deprivation-induced senescence and promoted sphere formation, growth, or metastasis of NB stem cells. +other 35318393 hsa-mir-16 Uterine Cervical Neoplasms miR-16 has been shown to influence autophagy in cervical cancer. +target gene 35318311 hsa-mir-542 Breast Neoplasms CircRBM33 downregulation inhibits hypoxia-induced glycolysis and promotes apoptosis of breast cancer cells via a microRNA-542-3p/HIF-1α axis. +lncRNA target 35318304 hsa-mir-508 Endometrial Neoplasms 5p/SOX2 axis has potential value in modulating ECSC maintenance, chemoresistance, and tumorigenesis in EC, which highlights a novel promising target for EC treatment. +circRNA target 35318303 hsa-mir-198 Prostatic Neoplasms The consequences of high-dose-DHT suppressed circRNA-BCL2/miRNA-198/AMBRA1 signaling likely result in induction of the autophagic cell death to suppress the EnzR CRPC cell growth. +lncRNA target 35317841 hsa-mir-346 Prostatic Neoplasms Importantly, miR-346 sensitises PC cells to DNA-damaging drugs including PARP inhibitor and chemotherapy, and induces tumour regression as a monotherapy in vivo, indicating that targeting miR-346:NORAD balance is a valid therapeutic strategy. +lncRNA target 35317822 hsa-mir-874 Endometrial Neoplasms 3p to regulate EMT in endometrial cancer via the miR +transcription factor target 35317779 hsa-mir-106b Esophageal Squamous Cell Carcinoma Furthermore, miR-106b-5p inhibited HPGD expression, thereby suppressing ESCC tumorigenesis. +circulation_biomarker_diagnosis_up 35317728 hsa-mir-20 Emergence Delirium Compared with NPOD patients, the expressions of plasma miR-320 and APP protein were increased and the expression of plasma IGF-1 mRNA was decreased in POD patients after surgery. +circulation_biomarker_prognosis_ns 35317445 hsa-mir-200a Carcinoma, Non-Small-Cell Lung Collectively, it was revealed that miR-200a-3p and GATA6 were abnormally expressed in the peripheral blood of patients with NSCLC. +genetics_knock down_promote 35317442 hsa-mir-1205 salivary gland adenoid cystic carcinoma The knockdown of hsa_circ_0011946 expression inhibited the proliferation, invasion and migration of SACC cells, thereby inhibiting the EMT process, which was achieved by downregulating miR-1205 expression. +genetics_overexpression_suppress 35317439 hsa-mir-150 ankylosing spondylitis 1 5p overexpression decreased osteogenic transformation of fibroblasts by decreasing VDR expression in AS. +circulation_biomarker_diagnosis_down 35317427 hsa-mir-129-1 Stomach Neoplasms 1-3p was significantly down-regulated in GC compared to AG (P = 0.0021 and P = 0.024, tissue and plasma, respectively). +other 35317427 hsa-mir-215 Stomach Neoplasms Moreover, analysis revealed that hsa-miR3p/5p and hsa-miR-934 were significantly deregulated in GC based on Helicobacter pylori (H. +other 35317427 hsa-mir-934 Stomach Neoplasms Moreover, analysis revealed that hsa-miR3p/5p and hsa-miR-934 were significantly deregulated in GC based on Helicobacter pylori (H. +other 35317418 hsa-mir-132 Fetal Growth Retardation Further studies are needed to investigate the role of miR-132 in the management of late-onset FGR. +lncRNA target 35317281 hsa-mir-10b Arthritis Herein, we describe that microRNA-10b-5p (miR-10b) promotes RA progression by disrupting the balance between subsets of CD4(+) T cells. The present findings suggest that miR-10b could disrupt the balance of CD4(+) T subsets, while suppressed miR-10b could attenuate the severity of experimental arthritis, which provided us a novel mechanistic and therapeutic insight into the RA. +exosome 35317202 hsa-mir-652 Breast Neoplasms synergistic action of exosomal miR-185-5p, miR-652-5p, and miR-1246 boosted fibroblast migration and contraction, promoting specific CAF subspecialization toward a pro-migratory functional state. +exosome 35317202 hsa-mir-1246 Breast Neoplasms synergistic action of exosomal miR-185-5p, miR-652-5p, and miR-1246 boosted fibroblast migration and contraction, promoting specific CAF subspecialization toward a pro-migratory functional state. +exosome 35317202 hsa-mir-185 Breast Neoplasms synergistic action of exosomal miR-185-5p, miR-652-5p, and miR-1246 boosted fibroblast migration and contraction, promoting specific CAF subspecialization toward a pro-migratory functional state. +circulation_biomarker_diagnosis_up 35316914 hsa-mir-21 Enterocolitis, Necrotizing MATERIAL AND METHODS: Collecting 30 pairs of newborn and NEC children and measuring the miRNA-21 expression in the serum of 30 pairs. +transcription factor target 35316906 hsa-mir-29b Pre-Eclampsia CONCLUSIONS: The down-regulation of miR-29b-3p could improve HTR-8/SVneo cell biological activities in a preeclampsia cell model by targeting B2R. +circulation_biomarker_diagnosis_up 35316895 hsa-mir-18a Polycystic Ovary Syndrome MATERIAL AND METHODS: Real-time PCR was performed to compare the levels of irisin, blood glucose, UCA1 and miR-18a among PCOS, PCOS Met, and control groups using area under curve (AUC) values. +other 35316894 hsa-mir-29b Dmd-Associated Dilated Cardiomyopathy Except for a single measurement of miR-29b at 3 months (DCM with fibrosis: 6.03 0.72 vs. DCM without fibrosis: 6.4 0.75 Cq; p < 0.05), baseline, 3- and 12-month kinetics of microRNAs did not differ between the two groups. +other 35316894 hsa-mir-29 Dmd-Associated Dilated Cardiomyopathy Except for a single measurement of miR-29b at 3 months (DCM with fibrosis: 6.03 0.72 vs. DCM without fibrosis: 6.4 0.75 Cq; p < 0.05), baseline, 3- and 12-month kinetics of microRNAs did not differ between the two groups. +lncRNA target 35316874 hsa-mir-4484 Stomach Neoplasms Both miR-4484 and ITGA6 may be the new prognostic markers and potential therapeutic targets of gastric cancer. +lncRNA target 35316873 hsa-mir-153 Lymphoma, Large B-Cell, Diffuse Conclusion: Down-regulation of circZNF609 inhibits the proliferation of diffuse large B-cell lymphoma OCI-LY19 cells and induces apoptosis by targeting miR-153. +exosome 35316648 hsa-mir-9 Spinal Cord Injuries In conclusion, our findings indicated that exosomal miR +circulation_biomarker_diagnosis_ns 35316486 hsa-mir-152 Histiocytic Sarcoma After HM, miR152-3p, miR143-3p, miR27a-3p levels increased while miR30b-3p decreased in both females and males: circulating miRNAs mirrored these modulations. +circulation_biomarker_diagnosis_ns 35316486 hsa-mir-143 Histiocytic Sarcoma After HM, miR152-3p, miR143-3p, miR27a-3p levels increased while miR30b-3p decreased in both females and males: circulating miRNAs mirrored these modulations. +circulation_biomarker_diagnosis_ns 35316486 hsa-mir-27a Histiocytic Sarcoma After HM, miR152-3p, miR143-3p, miR27a-3p levels increased while miR30b-3p decreased in both females and males: circulating miRNAs mirrored these modulations. +genetics_overexpression_suppress 35316152 hsa-mir-376a Leukemia, Myeloid, Acute The rescue experiments further confirmed that miR-376a-3p could reverse the promotion of MT1X overexpression on the progress of AML cells. +lncRNA target 35316129 hsa-mir-182 Triple Negative Breast Neoplasms CONCLUSION: SLC16A1-AS1 may inhibit cell cycle progression and restrain TNBC cell proliferation by regulating the miR-182/PDCD4 axis. +genetics_overexpression_suppress 35315499 hsa-mir-450b Myocardial Reperfusion Injury Subsequently, the regulatory mechanism underlying the lncRNA SNHG1/miR450b5p/IGF1 axis in MIRI was investigated by overexpressing miR450b5p and knocking down IGF1 expression in H/Rinduced cells. +lncRNA target 35315366 hsa-mir-195 Carcinoma, Non-Small-Cell Lung Therefore, we believe that APS could inhibit the proliferation and migration of NSCLC cells by regulating miR +exosome 35315295 hsa-mir-424 Squamous Cell Carcinoma of Head and Neck ER-stressed HNSCC cell-induced exosomal miR5p inhibits angiogenesis and migration of HUVEC cells through LAMC1-mediated Wnt/beta-catenin signaling pathway. +genetics_GWAS 35315037 hsa-mir-146a Stomach Neoplasms The rs2910164 polymorphism of the miR-146a gene may reduce the risk of gastric cancer by influencing the processing of mature miR-146a. +genetics_overexpression_promote 35314531 hsa-mir-152 Cystadenocarcinoma, Serous, Endometrial MiR-152 overexpression increased apoptosis and inhibited the proliferation of the two ESC cell lines. +other 35314529 hsa-let-7d Glomerulonephritis, IGA Here, hsa-miR-451a and hsa-let-7d-3p were upregulated in IgAN patients compared with healthy controls. These findings suggest that hsa-miR-451a and hsa-let-7d-3p may serve as noninvasive biomarkers for the evaluation of IgAN. +other 35314529 hsa-mir-451a Glomerulonephritis, IGA Here, hsa-miR-451a and hsa-let-7d-3p were upregulated in IgAN patients compared with healthy controls. These findings suggest that hsa-miR-451a and hsa-let-7d-3p may serve as noninvasive biomarkers for the evaluation of IgAN. +circulation_biomarker_diagnosis_ns 35314361 hsa-mir-24 Dermatitis, Atopic The plasma miR-24 and miR-191 levels of the AD patients were correlated with their serum thymus and activation-regulated chemokine levels. +circulation_biomarker_diagnosis_ns 35314361 hsa-mir-191 Dermatitis, Atopic The plasma miR-24 and miR-191 levels of the AD patients were correlated with their serum thymus and activation-regulated chemokine levels. +other 35313857 hsa-let-7d Carcinoma, Non-Small-Cell Lung LUSC patients with high let-7d-3p expression had poor overall survival rates (OS). +circulation_biomarker_diagnosis_ns 35313857 hsa-mir-199a Carcinoma, Non-Small-Cell Lung 5p in peripheral blood of NSCLC patients was higher than the healthy controls. +lncRNA target 35313857 hsa-mir-186 Carcinoma, Non-Small-Cell Lung 3p, and hsa-let-7d-3p) were screened from 3 databases, and 6 upstream transcription factors and 2253 downstream target genes were predicted. +lncRNA target 35313857 hsa-mir-28 Carcinoma, Non-Small-Cell Lung 3p, and hsa-let-7d-3p) were screened from 3 databases, and 6 upstream transcription factors and 2253 downstream target genes were predicted. +lncRNA target 35313796 hsa-mir-23a Medulloblastoma We identified GLS (glutaminase), a glutamine metabolism enzyme, was directly targeted by miR-23a-3p in MB cells. +other 35313568 hsa-mir-133b Stomach Neoplasms CONCLUSION: Our studies suggest that HuR and miR-133b are involved in the development and pathological process of GC cells. +genetics_overexpression_promote 35313299 hsa-mir-199a Leukemia, Myelogenous, Chronic, BCR-ABL Positive Both miR-199a-3p overexpression and mTOR silencing inhibited CML cell proliferation, promoted CML cell apoptosis, and sensitized these cells to imatinib. +lncRNA target 35313261 hsa-mir-493 Ovarian Neoplasms 3p through targeting DPY30 in ovarian cancer, indicating that miR +circulation_biomarker_diagnosis_ns 35313225 hsa-mir-204 Pre-Eclampsia 5p levels were higher in PE serum. +lncRNA target 35313071 hsa-mir-575 Head and Neck Neoplasms Collectively, our study provides mechanistic insights into the role of DRP1 in HNC and highlights the potential of targeting the miR-575/DRP1/FOXM1/MMP12 axis as a novel therapy for the prevention of HNC progression. +genetics_knock down_promote 35312836 hsa-mir-145 Colorectal Neoplasms Moreover, proliferation, clone formation, and apoptosis in CRC cells treated with 5-FU were assessed after gain- or loss-of-function of ATF4, miR-145, and/or HDAC4. +other 35312280 hsa-mir-342 Triple Negative Breast Neoplasms 3p in the miRNA-extracts from cancer cell lines and TNBC patient-derived xenografts. +genetics_knock down_promote 35312228 hsa-mir-21 Osteoporosis After confirming that miR-21 deficiency retards the beta1/2-AR agonist isoproterenol (ISO)-induced osteopenia, it is shown that the pharmacological inhibition of exosome release by two clinically-relevant drugs, dimethyl amiloride and omeprazole, suppresses osteoblastic miR-21 transfer and ameliorates bone loss under both ISO and chronic variable stress (CVS)-induced depression conditions. A targeted delivery approach to specifically silence osteoblastic miR-21 is further applied, which is effective in rescuing the bone remodeling balance and ameliorating ISO- and CVS-induced osteopenias. +lncRNA target 35312153 hsa-mir-140 Acute Kidney Injury These results cumulatively show that HIF-1alpha regulates mitophagy during AKI through the regulation of miR +circRNA target 35312115 hsa-mir-494 Esophageal Squamous Cell Carcinoma CONCLUSION: Circ_0007142 improved DDP resistance of ESCC by upregulating LASP1 via sponging miR3p. +other 35312113 hsa-mir-1294 Uterine Cervical Neoplasms CONCLUSION: Hsa_circ_0018289 contributes to malignant development by regulating the miR-1294/ICMT axis, affording novel insight into CC therapy. +lncRNA target 35311623 hsa-mir-424 Stomach Neoplasms 5p/Smad7 axis and thus could be a promising target for GC therapy. +lncRNA target 35311457 hsa-mir-587 Carcinoma, Ovarian Epithelial Quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting results showed that ADAMTS9-AS1 expression was elevated in EOC cells; microRNA-587 expression was up-regulated and SLC7A11 expression was down-regulated after knocking down ADAMTS9-AS1 by transfection with siRNAs; however, microRNA-587 inhibitor reversed SLC7A11 expression in ADAMTS9-AS1 knocking down cells. In conclusion, our study found that ADAMTS9-AS1 attenuated ferroptosis by targeting miR-587/SLC7A11 axis in EOC. +lncRNA target 35311456 hsa-mir-1305 Uterine Cervical Neoplasms In conclusion, circ_0072008 facilitated CESC cell proliferation, migration, and invasion through increasing HELLS expression by regulating miR-1305, which also offered an underlying targeted therapy for CESC treatment. +genetics_GWAS 35311447 hsa-mir-1 Urinary Bladder Neoplasms We also focused on the role of epigenetics in bladder tumors and verified that KRT6A was a miR +lncRNA target 35311115 hsa-mir-29a Acute Lymphoblastic Leukemia, B-Cell Through bioinformatics analyses and RT-qPCR validation, the lncRNA DUXAP8/miR-29a/PIK3CA network and PI3K-AKT-mTOR signaling were identified as significantly associated with B-ALL chemotherapy resistance. CONCLUSION: Targeting the lncRNA DUXAP8/miR-29a/PIK3CA network not only induced an apoptotic effect on Dox-resistant B-ALL and restored Dox chemosensitivity via PI3K-AKT-mTOR signaling but also showed synergism with inotuzumab ozogamicin treatment. +other 35311096 hsa-mir-211 Retinoblastoma 5p promotes carboplatin resistance in human retinoblastoma Y79 cells, and this process can be affected by GDNF-LIF interaction. +genetics_knock down_suppress 35310934 hsa-mir-590 Alzheimer Disease Our results showed that knockdown of miR +lncRNA target 35310933 hsa-mir-181a Osteosarcoma Moreover, we observed that miR-181a-5p mimic further inhibited growth of human osteosarcoma cells in the presence of adriamycin or cisplatin. +genetics_overexpression_promote 35310917 hsa-mir-217 Uterine Cervical Neoplasms The investigation of the mechanism showed that hsa-miR-217 silencing or HIF-1a overexpression rescued hsa_circ_0004543, and silencing inhibited malignant phenotypes of CC cells. +lncRNA target 35310916 hsa-mir-1178 Carcinoma, Non-Small-Cell Lung 3p sponge by targeting APITD1 that alleviated NSCLC progression. +other 35310909 hsa-mir-140 Ovarian Neoplasms The majority of hub genes are projected to be controlled by hsa-miR-429, hsa-miR5p, hsa-miR-199a-5p, and hsa-miR-199a-3p after the DEM-hub gene network was built. +other 35310909 hsa-mir-429 Ovarian Neoplasms The majority of hub genes are projected to be controlled by hsa-miR-429, hsa-miR5p, hsa-miR-199a-5p, and hsa-miR-199a-3p after the DEM-hub gene network was built. +other 35310909 hsa-mir-199a Ovarian Neoplasms The majority of hub genes are projected to be controlled by hsa-miR-429, hsa-miR5p, hsa-miR-199a-5p, and hsa-miR-199a-3p after the DEM-hub gene network was built. +lncRNA target 35310907 hsa-mir-1251 Carcinoma, Renal Cell 5p constrained ccRCC cell advancement, migration, and immune evasion via targeting NPTX2, providing novel insights into ccRCC target treatment. +circulation_biomarker_diagnosis_ns 35310355 hsa-mir-182 Glioma As a result, it could quantify miRNA-182 in serum of glioma patients, the concentration of which was significantly higher than that of healthy people and obviously decreased after surgery. +lncRNA target 35310196 hsa-mir-195 Squamous Cell Carcinoma of Head and Neck miR-195 blocks the NF-kappaB pathway via inhibiting the expression of TLR4 in OSCC cells, thereby exerting an antitumor effect. +lncRNA target 35309842 hsa-mir-217 Carcinoma, Hepatocellular inhibitor-transfected HCC cells were distinctly enhanced and the apoptosis rate (flow cytometry) was noticeably reduced. +other 35309364 hsa-mir-203a Sjogren's Syndrome When compared to tears from patients with MGD, miRNAs hsa-miR-203a-3p, hsa-miR-181a-5p and hsa-miR-181b-5p were also significantly increased in tears of SS patients. +other 35309364 hsa-mir-181b Sjogren's Syndrome When compared to tears from patients with MGD, miRNAs hsa-miR-203a-3p, hsa-miR-181a-5p and hsa-miR-181b-5p were also significantly increased in tears of SS patients. +other 35309364 hsa-mir-181a Sjogren's Syndrome When compared to tears from patients with MGD, miRNAs hsa-miR-203a-3p, hsa-miR-181a-5p and hsa-miR-181b-5p were also significantly increased in tears of SS patients. +transcription factor target 35309179 hsa-mir-340 Breast Neoplasms Taken together, sinomenine inhibits hypoxia-caused VM formation and metastasis of breast cancer SP cells by regulating the miR5p/SIAH2 axis. +lncRNA target 35309146 hsa-mir-1291 Intervertebral Disc Degeneration In the DEMis-DEMs network of IDD, miR-1291, miR-4270, and miR-320b had high connectivity with targeted DEMs. The area under the curve (AUC) of 10 DEMs including miR-1273e, miR-623, miR-518b, and miR-1291 in ROC analysis was more than 0.8, which indicated that those 10 DEMs had diagnostic value in distinguishing IDD from normal individuals. +circulation_biomarker_diagnosis_ns 35309127 hsa-mir-105 Esophageal Squamous Cell Carcinoma 5p entered ESCC cells and promoted tumor-relevant functions by mediating SPARCL1 and the FAK/Akt signaling pathway, which indicated that the treatment of ESCC via serum EVs might be a novel therapy and that miRNA +other 35309118 hsa-mir-195 Carcinoma, Hepatocellular Overall, the hsa_circ_0017264-hsa-miR5p-CHEK1/CDC25A/FOXK1 network might provide novel insights into the potential mechanisms underlying LIHC onset and progression. +target gene 35309116 hsa-mir-429 Stomach Neoplasms Ginsenoside Rg3 Alleviates Cisplatin Resistance of Gastric Cancer Cells Through Inhibiting SOX2 and the PI3K/Akt/mTOR Signaling Axis by Up-Regulating miR-429. +genetics_GWAS 35309115 hsa-mir-608 Tuberculosis The results indicated that the SNPs rs10035440 (DROSHA), rs7372209 (miR26-a1), rs1834306 (miR100), rs4919510 (miR608), and rs10739971 (pri-let-7a-1) were significantly associated with high risk and rs3746444 (miR499) and rs6505162 (miR423), with low risk of developing tuberculosis in the Amazon population. +genetics_GWAS 35309115 hsa-mir-26 Tuberculosis The results indicated that the SNPs rs10035440 (DROSHA), rs7372209 (miR26-a1), rs1834306 (miR100), rs4919510 (miR608), and rs10739971 (pri-let-7a-1) were significantly associated with high risk and rs3746444 (miR499) and rs6505162 (miR423), with low risk of developing tuberculosis in the Amazon population. +genetics_GWAS 35309115 hsa-mir-100 Tuberculosis The results indicated that the SNPs rs10035440 (DROSHA), rs7372209 (miR26-a1), rs1834306 (miR100), rs4919510 (miR608), and rs10739971 (pri-let-7a-1) were significantly associated with high risk and rs3746444 (miR499) and rs6505162 (miR423), with low risk of developing tuberculosis in the Amazon population. +genetics_GWAS 35309115 hsa-let-7a-1 Tuberculosis The results indicated that the SNPs rs10035440 (DROSHA), rs7372209 (miR26-a1), rs1834306 (miR100), rs4919510 (miR608), and rs10739971 (pri-let-7a-1) were significantly associated with high risk and rs3746444 (miR499) and rs6505162 (miR423), with low risk of developing tuberculosis in the Amazon population. +genetics_GWAS 35309115 hsa-mir-499 Tuberculosis The results indicated that the SNPs rs10035440 (DROSHA), rs7372209 (miR26-a1), rs1834306 (miR100), rs4919510 (miR608), and rs10739971 (pri-let-7a-1) were significantly associated with high risk and rs3746444 (miR499) and rs6505162 (miR423), with low risk of developing tuberculosis in the Amazon population. +genetics_GWAS 35309115 hsa-mir-423 Tuberculosis The results indicated that the SNPs rs10035440 (DROSHA), rs7372209 (miR26-a1), rs1834306 (miR100), rs4919510 (miR608), and rs10739971 (pri-let-7a-1) were significantly associated with high risk and rs3746444 (miR499) and rs6505162 (miR423), with low risk of developing tuberculosis in the Amazon population. +other 35309064 hsa-mir-224 Abortion, Habitual CONCLUSION: In this study, we found that circ-CYP24A1 plays a role in RM by impairing the balance of cell proliferation and apoptosis by sponging miR-224, thereby regulating PRLR. +other 35308338 hsa-mir-164 CLAPO Syndrome The primary miR164-NAC1 network is potentially involved in plant defense responses against CLas from the early infection stage to symptom development. +circRNA target 35308166 hsa-mir-183 Thyroid Neoplasms Initial results revealed that circRNA_0057209 and STK4 were both reduced, while miR-183 was up-regulated in thyroid cancer tissues and cells. Altogether, our findings indicated that circRNA_0057209 may serve as a competing endogenous RNA of miR-183 to increase STK4 expression, thus inhibiting the development of thyroid cancer. +genetics_overexpression_promote 35307984 hsa-mir-10b Esophageal Neoplasms CONCLUSIONS: Overexpression of circATIC hampered ESCA progression and promoted radiosensitivity depending on the regulation of miR-10b-3p and RHCG. +lncRNA target 35307914 hsa-mir-4742 Carcinoma, Non-Small-Cell Lung In conclusion, LINC01140 inhibited NSCLC progression and cisplatin resistance via functioning as a ceRNA for miR +other 35307828 hsa-mir-29 Cognition Disorders This study also examined the prevalence of variants at the miR-29 binding site of COL4A1 in 73 Finnish VCI patients. +genetics_overexpression_promote 35307709 hsa-mir-942 Carcinoma, Renal Cell Besides that, propofol decreased miR-942 expression, and miR-942 overexpression attenuated the effects of propofol on ccRCC cells. +epigenetics 35307582 hsa-mir-451 Leukemia, Myeloid, Acute In the future, we will continue to include more cases and exclude the others factor influencing ABO antigen expression, promoter methylation and oxidative stress, to replicate the results of this study and investigate the underlying mechanism of decreasing miR-16 and miR-451 in AML patients with varied ABO antigen expression levels. +epigenetics 35307582 hsa-mir-16 Leukemia, Myeloid, Acute In the future, we will continue to include more cases and exclude the others factor influencing ABO antigen expression, promoter methylation and oxidative stress, to replicate the results of this study and investigate the underlying mechanism of decreasing miR-16 and miR-451 in AML patients with varied ABO antigen expression levels. +lncRNA target 35307379 hsa-mir-30 Osteosarcoma Through in vivo experiments, we further confirmed that circ_0078767 targeted miR +genetics_knock down_promote 35307327 hsa-mir-100 Carcinoma, Non-Small-Cell Lung HAGLROS repressed miR-100 expression to promote SMARCA5 expression in NSCLC cells, and miR-100 overexpression or SMARCA5 knockdown counteracted the oncogenic functions of HAGLROS. CONCLUSIONS: These results conclude that HAGLROS is a tumor promoter in NSCLC, and it regulates the malignant phenotypes of NSCLC cells via miR-100/SMARCA5 axis. +lncRNA target 35307061 hsa-mir-499 Cardiomyopathies Targeted regulation of miR-499 expression may be an effective way to treat SMD. +other 35306965 hsa-mir-543 Nasopharyngeal Carcinoma CONCLUSION: CP restrains the growth, migration and invasion of NPC cells and is negatively regulated by miR-543. +target gene 35306579 hsa-mir-93 Ovarian Neoplasms miR-93-5p suppresses ovarian cancer malignancy and negatively regulate CCND2 by binding to its 3'UTR region. +genetics_overexpression_promote 35306563 hsa-mir-22 Carcinoma, Hepatocellular 3p inhibition or YARS overexpression partially blocked the function of NCK1-AS1 deficiency in HCC cells. +circRNA target 35306484 hsa-mir-214 Cardiomegaly CONCLUSIONS: Our data demonstrated that circRNA_0001006 exacerbates cardiac hypertrophy via suppressing miR3p leading to enhanced PAK6 levels. +genetics_overexpression_promote 35306455 hsa-mir-141 Brain Injuries 3p overexpression alleviated ICH-induced brain injury and protected BBB integrity in vivo. +genetics_overexpression_promote 35306455 hsa-mir-141 Cerebral Hemorrhage 3p overexpression alleviated ICH-induced brain injury and protected BBB integrity in vivo. +circulation_biomarker_diagnosis_up 35306433 hsa-mir-17 Diabetes, Gestational 5p was upregulated in human GDM plasma and placentas along with the reduced Mfn1/Mfn2. +lncRNA target 35306368 hsa-mir-7 Stomach Neoplasms PURPOSE: To investigate the molecular mechanism and effects of BAI inhibiting progression of gastric cancer mediating miR-7/FAK/AKT signaling pathway. +other 35306280 hsa-mir-155 Hepatitis B CONCLUSIONS: Thus, MALAT1 may play an important role in NK cell-mediated immunity in TDF-treated pregnant women with HBV infection by regulating the has-miR5p/HIF-1alpha axis. +transcription factor target 35306215 hsa-mir-296 Fluorosis, Dental 5p, AMPK/ULK1 may be potential therapeutic targets under the higher fluoride stimulation. +other 35306215 hsa-mir-296 Fluoride Poisoning Our purpose is to explore the function of miR5p in regulating autophagy of excessive fluoride development. +lncRNA target 35306001 hsa-mir-2208b Tauopathies Importantly, RT-qRCR results suggested that 6 miRNAs (miR-786, miR-2208b, miR-34, miR-241, miR-247 and miR-4805), 8 lncRNAs (MSTRG.20812.2, MSTRG.22617.2, MSTRG.28210.13, MSTRG.5728.12, MSTRG.29708.1, MSTRG.3342.25, MSTRG.3342.31 and MSTRG.8841.8) and 7 mRNAs (nas-33, math-28, T14B4.19, col-17, rol-6, sqt-1 and irg-4) were potential targets of ginsenoside Rf inhibition of tauopathy. +lncRNA target 35306001 hsa-mir-4 Tauopathies Importantly, RT-qRCR results suggested that 6 miRNAs (miR-786, miR-2208b, miR-34, miR-241, miR-247 and miR-4805), 8 lncRNAs (MSTRG.20812.2, MSTRG.22617.2, MSTRG.28210.13, MSTRG.5728.12, MSTRG.29708.1, MSTRG.3342.25, MSTRG.3342.31 and MSTRG.8841.8) and 7 mRNAs (nas-33, math-28, T14B4.19, col-17, rol-6, sqt-1 and irg-4) were potential targets of ginsenoside Rf inhibition of tauopathy. +lncRNA target 35306001 hsa-mir-4805 Tauopathies Importantly, RT-qRCR results suggested that 6 miRNAs (miR-786, miR-2208b, miR-34, miR-241, miR-247 and miR-4805), 8 lncRNAs (MSTRG.20812.2, MSTRG.22617.2, MSTRG.28210.13, MSTRG.5728.12, MSTRG.29708.1, MSTRG.3342.25, MSTRG.3342.31 and MSTRG.8841.8) and 7 mRNAs (nas-33, math-28, T14B4.19, col-17, rol-6, sqt-1 and irg-4) were potential targets of ginsenoside Rf inhibition of tauopathy. +lncRNA target 35306001 hsa-mir-786 Tauopathies Importantly, RT-qRCR results suggested that 6 miRNAs (miR-786, miR-2208b, miR-34, miR-241, miR-247 and miR-4805), 8 lncRNAs (MSTRG.20812.2, MSTRG.22617.2, MSTRG.28210.13, MSTRG.5728.12, MSTRG.29708.1, MSTRG.3342.25, MSTRG.3342.31 and MSTRG.8841.8) and 7 mRNAs (nas-33, math-28, T14B4.19, col-17, rol-6, sqt-1 and irg-4) were potential targets of ginsenoside Rf inhibition of tauopathy. +transcription factor target 35305977 hsa-mir-153 Ischemic Stroke Thus, miR-203a-3p and miR3p confers neuroprotective effects against ischemic stroke via attenuation of apoptosis, oxidative stress and inflammatory pathways through inhibiting SRC-dependent MAPK signaling pathway in vivo and in vitro, suggesting new therapeutic targets for the prevention and treatment of stroke. +transcription factor target 35305977 hsa-mir-203a Ischemic Stroke Thus, miR-203a-3p and miR3p confers neuroprotective effects against ischemic stroke via attenuation of apoptosis, oxidative stress and inflammatory pathways through inhibiting SRC-dependent MAPK signaling pathway in vivo and in vitro, suggesting new therapeutic targets for the prevention and treatment of stroke. +exosome 35305974 hsa-mir-181a-2 Diabetes Mellitus, Type 2 In this study, we pointed out that exosomal miR-181a +exosome 35305974 hsa-mir-181a-2 Fibrosis In this study, we pointed out that exosomal miR-181a3p from CIT-treated hepatocytes induced mitochondrial calcium accumulation and activated HSC subsequently through inhibiting the expression of MICU1, shedding new light on the mechanism underlying liver fibrosis and CIT hepatotoxicity. +circulation_biomarker_diagnosis_up 35305574 hsa-mir-378 Tuberculosis, Pulmonary Serum miR-378 expression > 1.490 had high sensitivity and specificity in TB diagnosis. +other 35305556 hsa-mir-155 Sepsis 5p positively correlated with procalcitonin and interleukin-6 in patients treated with a non-nephrotoxic antibiotic. +other 35305556 hsa-mir-423 Sepsis 5p positively correlated with procalcitonin and interleukin-6 in patients treated with a non-nephrotoxic antibiotic. +other 35305556 hsa-mir-15a Sepsis By day 7 of gentamicin treatment miR-15a-5p provided good discrimination between AKI and non-AKI (area under curve, 0.828). +other 35305556 hsa-mir-192 Sepsis 5p positively correlated with procalcitonin and interleukin-6 in patients treated with a non-nephrotoxic antibiotic. +lncRNA target 35305236 hsa-mir-584 Neuroblastoma 5p and miR-34a-5p, which also offered an underlying targeted therapy for NB treatment. +lncRNA target 35305236 hsa-mir-34a Neuroblastoma 5p and miR-34a-5p, which also offered an underlying targeted therapy for NB treatment. +lncRNA target 35305106 hsa-mir-27b Ovarian Neoplasms MicroRNA-27b, MicroRNA-23a, and MicroRNA-590 may directly targeting GBAS affects the biological behavior of OC cells. +lncRNA target 35305106 hsa-mir-23a Ovarian Neoplasms MicroRNA-27b, MicroRNA-23a, and MicroRNA-590 may directly targeting GBAS affects the biological behavior of OC cells. +lncRNA target 35305106 hsa-mir-590 Ovarian Neoplasms MicroRNA-27b, MicroRNA-23a, and MicroRNA-590 may directly targeting GBAS affects the biological behavior of OC cells. +lncRNA target 35304834 hsa-mir-23b Cardiomyopathies CONCLUSIONS: This study supported that silencing Sox2OT inhibited CME-induced MI by eliminating Sox2OT/miR-23b binding and down-regulating the TLR4/NF-kappaB pathway. +circulation_biomarker_diagnosis_ns 35304668 hsa-mir-98 Asthma 5p expression in plasma of asthmatic patients and IL +other 35304514 hsa-mir-206 Breast Neoplasms MiR-206 is reported to be down-regulated in Luminal-A type of breast cancer. +other 35304180 hsa-mir-462 Walker-Warburg Syndrome The teleost specific miR-462/miR-731 cluster was strongly induced in POMV infected fish and deemed a potential biomarker of early infection. +other 35304180 hsa-mir-731 Walker-Warburg Syndrome The teleost specific miR-462/miR-731 cluster was strongly induced in POMV infected fish and deemed a potential biomarker of early infection. +other 35304174 hsa-mir-489 Neuropathic Allodynia 3p/DEK/TET1 transcriptional axis may contribute to neuropathic allodynia. +other 35304162 hsa-mir-34a Diabetic Retinopathy In severe NPDR group along with highly increased levels of both miR-146a and miR-21, a marked decrease in miR-34a. In PDR group miR-34a was almost diminished along with very high levels of both miR-146a and miR-21. +circulation_biomarker_prognosis_up 35304162 hsa-mir-21 Diabetic Retinopathy RESULTS: Serum relative expressions of miR-146a and miR-21 were increased with increased severity of DR. +circulation_biomarker_prognosis_up 35304162 hsa-mir-146a Diabetic Retinopathy RESULTS: Serum relative expressions of miR-146a and miR-21 were increased with increased severity of DR. +genetics_knock down_suppress 35304105 hsa-mir-142 Alzheimer Disease CONCLUSION: These data illustrated that knockdown of RMRP inhibited autophagy and apoptosis via regulating miR-3142/TRIB3 axis in AD, suggesting that inhibition of RMRP maybe a therapeutic strategy for AD. +lncRNA target 35303885 hsa-mir-539 Osteoarthritis MiR3p may have significant clinical applications for use as a targeted therapy of OA. +genetics_overexpression_promote 35303795 hsa-mir-140 Arthritis, Rheumatoid Overexpression of SGK1 reversed the inhibition of RASF growth caused by overexpression of miR +genetics_knock down_suppress 35303564 hsa-mir-23a Reperfusion Injury Here, we investigated the effects of exosomal miR-23a-3p on gut damage using primary IECs that underwent oxygen-glucose deprivation (OGD) as well as II/R rats. Injection of miR-23a-3p knockdown exosomes aggravated the II/R injury, whereas PF-6260933, a small-molecule inhibitor of MAP4K4, partly reversed the injury. +genetics_overexpression_promote 35303413 hsa-mir-122 Fibrosis In summary, miR5p overexpression exerted anti-fibrosis effect and inhibited HSC activation by suppressing the c-Abl/HDAC2 pathway. +genetics_knock down_promote 35303365 hsa-mir-363 Prostatic Neoplasms 3p along with Dickkopf 3 (DKK3) were assessed in clinical PCa specimens. +circulation_biomarker_diagnosis_up 35302725 hsa-mir-126 Lung Neoplasms The most significant serum miRNA biomarkers for the early detection of lung cancer are as follows: miR-143, let-7g, miR-126, let-7a, and miR-145 (miR-143 and miR-145 have oncogene functions, while miR-126, let-7g and let-7a have suppressor functions). +circulation_biomarker_diagnosis_up 35302725 hsa-mir-143 Lung Neoplasms The most significant serum miRNA biomarkers for the early detection of lung cancer are as follows: miR-143, let-7g, miR-126, let-7a, and miR-145 (miR-143 and miR-145 have oncogene functions, while miR-126, let-7g and let-7a have suppressor functions). +circulation_biomarker_diagnosis_up 35302725 hsa-let-7a Lung Neoplasms The most significant serum miRNA biomarkers for the early detection of lung cancer are as follows: miR-143, let-7g, miR-126, let-7a, and miR-145 (miR-143 and miR-145 have oncogene functions, while miR-126, let-7g and let-7a have suppressor functions). +circulation_biomarker_diagnosis_up 35302725 hsa-let-7g Lung Neoplasms The most significant serum miRNA biomarkers for the early detection of lung cancer are as follows: miR-143, let-7g, miR-126, let-7a, and miR-145 (miR-143 and miR-145 have oncogene functions, while miR-126, let-7g and let-7a have suppressor functions). +circulation_biomarker_diagnosis_up 35302725 hsa-mir-145 Lung Neoplasms The most significant serum miRNA biomarkers for the early detection of lung cancer are as follows: miR-143, let-7g, miR-126, let-7a, and miR-145 (miR-143 and miR-145 have oncogene functions, while miR-126, let-7g and let-7a have suppressor functions). +genetics_knock down_promote 35302673 hsa-mir-520a Carcinoma, Non-Small-Cell Lung Knockdown of hsa_circ_0017620 inhibited cell proliferation, migration, and invasion in NSCLC cells, which was reversed by downregulating miR-520a-5p or upregulating KRT5 in NSCLC. +circulation_biomarker_diagnosis_up 35302437 hsa-mir-497 Acute Coronary Syndrome Our study suggests that serum miR +circRNA target 35302432 hsa-mir-423 Stomach Neoplasms In conclusion, circRNA-0000081 promotes the function of GC through sponging hsa-miR5p to influence PDPK1 expression, which has a promising therapeutic potential for treating patients with GC. +circulation_biomarker_diagnosis_ns 35302299 hsa-mir-21 Sciatica OBJECTIVES: To explore the relationship between the plasma and local expression of miR-21 with disease severity of lumbar disc herniation (LDH) patients with sciatic pain. CONCLUSIONS: Increased local miR-21 expressions are linked with clinical severity of LDH in patients with sciatic pain. +other 35302183 hsa-mir-25 Leukemia, Myeloid, Acute SIDT2 regulates the miR-25/NOX4/HuR axis and SIRT3 mRNA destabilization, leading to ROS-mediated TNF-α upregulation in HQ-treated U937 cells. +transcription factor target 35302171 hsa-mir-33a Leukemia, Myelogenous, Chronic, BCR-ABL Positive In conclusion, it was demonstrated that TRIB2 regulates miR33a5p to reverse IM resistance in CML, which may help identify novel targets and therapeutic strategies for the clinical treatment of IM resistance. +other 35301863 hsa-mir-124 Atrial Fibrillation A cluster containing AF stage, left ventricular end-diastolic diameter, left ventricular end-systolic diameter, left atrial diameter, atrial COL1A2 (collagen alpha-2(I) chain), and TASK-1 protein level was associated with increased expression of miR-25, miR-21, miR-34a, miR-23a, miR-124, miR-1, and miR-29b as well as decreased expression of miR-9 and miR-485. +other 35301863 hsa-mir-21 Atrial Fibrillation A cluster containing AF stage, left ventricular end-diastolic diameter, left ventricular end-systolic diameter, left atrial diameter, atrial COL1A2 (collagen alpha-2(I) chain), and TASK-1 protein level was associated with increased expression of miR-25, miR-21, miR-34a, miR-23a, miR-124, miR-1, and miR-29b as well as decreased expression of miR-9 and miR-485. +other 35301863 hsa-mir-34a Atrial Fibrillation A cluster containing AF stage, left ventricular end-diastolic diameter, left ventricular end-systolic diameter, left atrial diameter, atrial COL1A2 (collagen alpha-2(I) chain), and TASK-1 protein level was associated with increased expression of miR-25, miR-21, miR-34a, miR-23a, miR-124, miR-1, and miR-29b as well as decreased expression of miR-9 and miR-485. +other 35301863 hsa-mir-25 Atrial Fibrillation A cluster containing AF stage, left ventricular end-diastolic diameter, left ventricular end-systolic diameter, left atrial diameter, atrial COL1A2 (collagen alpha-2(I) chain), and TASK-1 protein level was associated with increased expression of miR-25, miR-21, miR-34a, miR-23a, miR-124, miR-1, and miR-29b as well as decreased expression of miR-9 and miR-485. +other 35301863 hsa-mir-1 Atrial Fibrillation A cluster containing AF stage, left ventricular end-diastolic diameter, left ventricular end-systolic diameter, left atrial diameter, atrial COL1A2 (collagen alpha-2(I) chain), and TASK-1 protein level was associated with increased expression of miR-25, miR-21, miR-34a, miR-23a, miR-124, miR-1, and miR-29b as well as decreased expression of miR-9 and miR-485. +other 35301863 hsa-mir-9 Atrial Fibrillation A cluster containing AF stage, left ventricular end-diastolic diameter, left ventricular end-systolic diameter, left atrial diameter, atrial COL1A2 (collagen alpha-2(I) chain), and TASK-1 protein level was associated with increased expression of miR-25, miR-21, miR-34a, miR-23a, miR-124, miR-1, and miR-29b as well as decreased expression of miR-9 and miR-485. +other 35301863 hsa-mir-29b Atrial Fibrillation A cluster containing AF stage, left ventricular end-diastolic diameter, left ventricular end-systolic diameter, left atrial diameter, atrial COL1A2 (collagen alpha-2(I) chain), and TASK-1 protein level was associated with increased expression of miR-25, miR-21, miR-34a, miR-23a, miR-124, miR-1, and miR-29b as well as decreased expression of miR-9 and miR-485. +other 35301863 hsa-mir-485 Atrial Fibrillation A cluster containing AF stage, left ventricular end-diastolic diameter, left ventricular end-systolic diameter, left atrial diameter, atrial COL1A2 (collagen alpha-2(I) chain), and TASK-1 protein level was associated with increased expression of miR-25, miR-21, miR-34a, miR-23a, miR-124, miR-1, and miR-29b as well as decreased expression of miR-9 and miR-485. +other 35301863 hsa-mir-23a Atrial Fibrillation A cluster containing AF stage, left ventricular end-diastolic diameter, left ventricular end-systolic diameter, left atrial diameter, atrial COL1A2 (collagen alpha-2(I) chain), and TASK-1 protein level was associated with increased expression of miR-25, miR-21, miR-34a, miR-23a, miR-124, miR-1, and miR-29b as well as decreased expression of miR-9 and miR-485. +lncRNA target 35301686 hsa-mir-1179 Carcinoma, Non-Small-Cell Lung Mechanistically, circ-PLCD1 acted as a competitive endogenous RNA (ceRNA) to sponge miR-375 and miR-1179 and elevate PTEN, a well-known inhibitor of oncogenic PI3K/AKT signaling, thereby repressing NSCLC tumorigenesis. +lncRNA target 35301686 hsa-mir-375 Carcinoma, Non-Small-Cell Lung Mechanistically, circ-PLCD1 acted as a competitive endogenous RNA (ceRNA) to sponge miR-375 and miR-1179 and elevate PTEN, a well-known inhibitor of oncogenic PI3K/AKT signaling, thereby repressing NSCLC tumorigenesis. +genetics_knock down_promote 35301291 hsa-mir-495 Nasopharyngeal Carcinoma miR-495 knockdown enhanced the expression of c-Myc, Cyclin D1, and survivin and accelerated NPC cell proliferation, migration, invasion, and EMT through targeting MET and activating the MET-eIF4G1 axis. +circulation_biomarker_diagnosis_up 35301154 hsa-mir-193b Pre-Eclampsia RESULTS: LncRNA MIR193BHG was upregulated in the serum of PE patients, and MIR193BHG expression in mPE patients was lower than that in sPE patients. +circulation_biomarker_diagnosis_ns 35301154 hsa-mir-345 Pre-Eclampsia 3p was poorly expressed and SASH was highly expressed in serum of PE patients. +genetics_knock down_suppress 35300972 hsa-mir-16 Vertigo Furthermore, circ_0000831, AdipoR2, or PPARgamma overexpression or miR +genetics_knock down_suppress 35300972 hsa-mir-16 Brain Ischemia Furthermore, circ_0000831, AdipoR2, or PPARgamma overexpression or miR +circulation_biomarker_diagnosis_ns 35300960 hsa-mir-4793 Stomach Neoplasms Among them, serum exosomal hsa-miR-1273 g-3p / hsa-miR +circulation_biomarker_diagnosis_ns 35300960 hsa-mir-1273g Stomach Neoplasms Among them, serum exosomal hsa-miR-1273 g-3p / hsa-miR +circulation_biomarker_diagnosis_ns 35300960 hsa-mir-619 Stomach Neoplasms Among them, serum exosomal hsa-miR-1273 g-3p / hsa-miR +circulation_biomarker_diagnosis_up 35300771 hsa-mir-29b Myocarditis Results Compared with healthy controls,the FM patients had up-regulated expression levels of miR-29b(t=18.925,P<0.001)and miR-125b(t=5.981,P=0.029)in the plasma.After treatment,the expression levels of miR-29b(t=12.943,P<0.001)and miR-125b(t=14.016,P<0.001)were significantly down-regulated.KEGG pathway enrichment showed that the targets of miR-29b were involved in inflammatory response and apoptosis pathways.The results of cell proliferation and apoptosis assay demonstrated the transfection of miR-29b mimic had a more significant inducing effect on cardiomyocyte apoptosis than that of miR-125b mimic(chi (2)=6.168,P=0.047),whereas there was no significant difference in the inhibition of cell proliferation between the two groups(chi(2)=1.452,P=0.417).The expression levels of miR-29b and miR-125b were negatively correlated with left ventricular ejection fraction(r=-0.67,P=0.071;r=-0.49,P=0.003).They were positively correlated with cardiac troponin I level(r=0.61,P=0.019;r=0.52,P=0.016),interferon beta level(r=0.42,P=0.014;r=0.36,P=0.021),and myocardial edema area(r=0.86,P=0.005;r=0.73,P=0.013).The ROC curve analysis demonstrated that miR-29b had higher sensitivity for the diagnosis of FM(93.6% vs.89.2%;t=0.896,P=0.795)and specificity(72.4% vs.59.6%;t=9.478,P=0.002)than miR-125b. Conclusion The circulating miR-29b may be a potential biomarker for the diagnosis of FM. +circulation_biomarker_diagnosis_up 35300771 hsa-mir-125b Myocarditis Results Compared with healthy controls,the FM patients had up-regulated expression levels of miR-29b(t=18.925,P<0.001)and miR-125b(t=5.981,P=0.029)in the plasma.After treatment,the expression levels of miR-29b(t=12.943,P<0.001)and miR-125b(t=14.016,P<0.001)were significantly down-regulated.KEGG pathway enrichment showed that the targets of miR-29b were involved in inflammatory response and apoptosis pathways.The results of cell proliferation and apoptosis assay demonstrated the transfection of miR-29b mimic had a more significant inducing effect on cardiomyocyte apoptosis than that of miR-125b mimic(chi (2)=6.168,P=0.047),whereas there was no significant difference in the inhibition of cell proliferation between the two groups(chi(2)=1.452,P=0.417).The expression levels of miR-29b and miR-125b were negatively correlated with left ventricular ejection fraction(r=-0.67,P=0.071;r=-0.49,P=0.003).They were positively correlated with cardiac troponin I level(r=0.61,P=0.019;r=0.52,P=0.016),interferon beta level(r=0.42,P=0.014;r=0.36,P=0.021),and myocardial edema area(r=0.86,P=0.005;r=0.73,P=0.013).The ROC curve analysis demonstrated that miR-29b had higher sensitivity for the diagnosis of FM(93.6% vs.89.2%;t=0.896,P=0.795)and specificity(72.4% vs.59.6%;t=9.478,P=0.002)than miR-125b. +transcription factor target 35300770 hsa-mir-490 Carcinoma, Non-Small-Cell Lung Conclusion Puerarin could inhibit the proliferation,invasion,and migration of non-small cell lung cancer cells by up-regulating miR-490 and down-regulating DTL. +transcription factor target 35300572 hsa-mir-7 Urinary Bladder Neoplasms 5p as a cancer suppressor gene in BCa and provide new opportunities for the treatment of BCa. +genetics_overexpression_suppress 35300565 hsa-mir-124 Carcinoma, Hepatocellular Overexpression of miR +genetics_overexpression_suppress 35300558 hsa-mir-124 Nasopharyngeal Carcinoma 3p overexpression-induced NPC cell radiosensitivity. +exosome 35300408 hsa-mir-483 Multiple Myeloma In summary, our study indicated that MM-MSCs promote MM malignant progression via the release of exosomes and regulation of miR +exosome 35300348 hsa-mir-132 Hepatoblastoma CONCLUSION: HB-derived exosomal lncRNA NEAT1 induced BMSCs differentiation into tumor-supporting myofibroblasts via modulating miR-132/MMP9 axis, which provided a new target for HB treatment. +genetics_knock down_suppress 35300347 hsa-mir-194 Thyroid Cancer, Papillary Moreover, miR-194 inhibition markedly abrogated the effects of circVANGL1 knockdown in PTC cells. +lncRNA target 35300139 hsa-mir-30 Myocardial Infarction The experimentally constructed miRNA-mRNA regulatory network found that hsa-miR-190b targets to inhibit FGF2, while hsa-miR3p targets to regulate MMP2, which may mediate Integrins in angiogenesis, Angiopoietin receptor Tie2-mediated signaling pathway to induce AMI pathogenesis, providing strong data support and a research direction for the prevention and treatment of AMI. +lncRNA target 35300139 hsa-mir-190b Myocardial Infarction The experimentally constructed miRNA-mRNA regulatory network found that hsa-miR-190b targets to inhibit FGF2, while hsa-miR3p targets to regulate MMP2, which may mediate Integrins in angiogenesis, Angiopoietin receptor Tie2-mediated signaling pathway to induce AMI pathogenesis, providing strong data support and a research direction for the prevention and treatment of AMI. +lncRNA target 35300071 hsa-mir-142 Osteoarthritis 5p to inhibit chondrocyte autophagy and promote chondrocyte proliferation in osteoarthritis. +genetics_knock down_promote 35300063 hsa-mir-760 Carcinoma, Non-Small-Cell Lung CONCLUSION: SLC9A3-AS1 was upregulated in NSCLC, and SLC9A3-AS1 knockdown hindered NSCLC progression through targeting miR-760, suggesting that it may prove to be a novel biomarker and therapeutic target for NSCLC. +genetics_overexpression_promote 35300057 hsa-mir-183 Prostatic Neoplasms 5p plasma, on the same patients' cohort versus a healthy control group, confirming the overexpression of these transcripts in the PRAD group, demonstrating the liquid biopsy as a potential investigational tool in prostate cancer. +genetics_overexpression_promote 35300057 hsa-mir-20b Prostatic Neoplasms 5p plasma, on the same patients' cohort versus a healthy control group, confirming the overexpression of these transcripts in the PRAD group, demonstrating the liquid biopsy as a potential investigational tool in prostate cancer. +genetics_overexpression_promote 35300057 hsa-mir-96 Prostatic Neoplasms 5p plasma, on the same patients' cohort versus a healthy control group, confirming the overexpression of these transcripts in the PRAD group, demonstrating the liquid biopsy as a potential investigational tool in prostate cancer. +transcription factor target 35299961 hsa-mir-200c Non-alcoholic Fatty Liver Disease The findings suggested that miR-200c-3p should be further explored as a potential target for the treatments of NAFLD. +other 35299889 hsa-mir-218 Glioma Furthermore, we shed light on the underlying mechanism of PTBP1 by constructing a miRTCF3-PTBP1 transcriptional network in glioma. +genetics_knock down_promote 35298438 hsa-mir-92a Encephalomyelitis, Autoimmune, Experimental miR-92a was elevated in experimental autoimmune encephalomyelitis (EAE), and its loss attenuated EAE. +lncRNA target 35298438 hsa-mir-92a Autoimmune Diseases of the Nervous System Here, we report a major disease-promoting role for microRNA-92a (miR-92a) in CNS autoimmunity. Together, our results demonstrate that miR-92a drives CNS autoimmunity by sustaining the Treg/Th17 imbalance and implicate miR-92a as a potential therapeutic target for MS. +genetics_overexpression_promote 35297352 hsa-mir-221 Ovarian Neoplasms CONCLUSION: Collectively, overexpression of LINC00936 suppressed the development of ovarian cancer by competitively binding to miR +lncRNA target 35297315 hsa-mir-940 Osteosarcoma Overall, these findings indicated that miR-940/ZDHHC19 axis played a significant role in OS progression and might be considered as a novel target for OS treatment.Abbreviations: OS, osteosarcoma; miRNAs, microRNAs; 3'-UTR, 3'- untranslated region; TARGET, Therapeutically Applicable Research To Generate Effective Treatments; qRT-PCR, quantitative real-time PCR; IHC, Immunohistochemistry; GSVA, Gene Set Variation Analysis; GSEA, Gene Set Enrichment Analysis; KEGG, Kyoto Encyclopedia of Genes and Genomes. +lncRNA target 35297212 hsa-mir-940 Esophageal Squamous Cell Carcinoma CONCLUSION: Circ_0003340 downregulation mitigated esophageal squamous cell carcinoma progression by targeting miR-940/PRKAA1 axis. +genetics_GWAS 35296964 hsa-mir-211 Breast Neoplasms Our findings revealed that TUSC7 functions as a tumor suppressor in BC potentially via miR-211/Nurr1, which might be disturbed by the cer-SNP rs2615499. +other 35296567 hsa-mir-9 Glomerulonephritis, Membranous 5p may become new non-invasive biomarkers of IMN. +genetics_overexpression_promote 35296211 hsa-mir-637 Neurodegenerative Diseases This study investigated the mechanism of miR-637 inhibiting osteogenic differentiation of human CESC by regulating WNT5A.Methods: The degenerative CEP (N = 10) and non-degenerative CEP (N = 6) were obtained from patients undergoing disk fusion surgery. After simultaneous overexpression of miR-637/WNT5A, the effect of miR-637 on osteogenic differentiation of CESCs was assessed.Results: miR-637 was down-expressed in degenerative CESCs (D-CESCs), and miR-637 overexpression inhibited the osteogenic differentiation of D-CESCs, while inhibition of miR-637 promoted the osteogenic differentiation ability of D-CESCs. +lncRNA target 35296211 hsa-mir-637 Porphyria, Erythropoietic This study investigated the mechanism of miR-637 inhibiting osteogenic differentiation of human CESC by regulating WNT5A.Methods: The degenerative CEP (N = 10) and non-degenerative CEP (N = 6) were obtained from patients undergoing disk fusion surgery. +genetics_knock down_suppress 35296158 hsa-mir-210 Myocardial Infarction phosphate dehydrogenase is a novel target of microRNA-210 in the heart, and loss-of-function and gain-of-function experiments revealed that glycerol +transcription factor target 35295962 hsa-mir-129-1 Triple Negative Breast Neoplasms 1-3p was illustrated to serve as a tumor repressor via targeting GRIN2D in TNBC cells and highlight that the restoration of miR +lncRNA target 35295711 hsa-mir-25 Carcinoma, Renal Cell In summary, circPSD3 inhibits tumor metastasis by repressing the miR3p/FBXW7-EMT axis and might be developed as a potential diagnostic and therapeutic target for ccRCC. +exosome 35295267 hsa-mir-210 Diabetes Mellitus, Type 2 Furthermore, we identified that five EV-carried miRNAs (miR-15a-3p, miR-18a-5p, miR-133a-3p, miR +exosome 35295267 hsa-mir-133a Myocardial Ischemia Furthermore, we identified that five EV-carried miRNAs (miR-15a-3p, miR-18a-5p, miR-133a-3p, miR +exosome 35295267 hsa-mir-15a Myocardial Ischemia Furthermore, we identified that five EV-carried miRNAs (miR-15a-3p, miR-18a-5p, miR-133a-3p, miR +exosome 35295267 hsa-mir-210 Myocardial Ischemia Furthermore, we identified that five EV-carried miRNAs (miR-15a-3p, miR-18a-5p, miR-133a-3p, miR +exosome 35295267 hsa-mir-155 Myocardial Ischemia Furthermore, we identified that five EV-carried miRNAs (miR-15a-3p, miR-18a-5p, miR-133a-3p, miR +exosome 35295267 hsa-mir-18a Myocardial Ischemia Furthermore, we identified that five EV-carried miRNAs (miR-15a-3p, miR-18a-5p, miR-133a-3p, miR +exosome 35295267 hsa-mir-19a Myocardial Ischemia Furthermore, we identified that five EV-carried miRNAs (miR-15a-3p, miR-18a-5p, miR-133a-3p, miR +exosome 35295267 hsa-mir-18a Diabetes Mellitus, Type 2 Furthermore, we identified that five EV-carried miRNAs (miR-15a-3p, miR-18a-5p, miR-133a-3p, miR +exosome 35295267 hsa-mir-155 Diabetes Mellitus, Type 2 Furthermore, we identified that five EV-carried miRNAs (miR-15a-3p, miR-18a-5p, miR-133a-3p, miR +exosome 35295267 hsa-mir-133a Diabetes Mellitus, Type 2 Furthermore, we identified that five EV-carried miRNAs (miR-15a-3p, miR-18a-5p, miR-133a-3p, miR +exosome 35295267 hsa-mir-19a Diabetes Mellitus, Type 2 Furthermore, we identified that five EV-carried miRNAs (miR-15a-3p, miR-18a-5p, miR-133a-3p, miR +exosome 35295267 hsa-mir-15a Diabetes Mellitus, Type 2 Furthermore, we identified that five EV-carried miRNAs (miR-15a-3p, miR-18a-5p, miR-133a-3p, miR +transcription factor target 35295173 hsa-mir-27a Intervertebral Disc Degeneration CONCLUSION: MiR-27a-3p may target RASSF5 and enhance cell proliferation and imped cell apoptosis of the nucleus pulposus cells via the MST1/LATS1 and RAS/RAC1 pathway, lessening the degeneration of intervertebral discs. +lncRNA target 35295003 hsa-mir-18a Prostatic Neoplasms Moreover, mechanistic analysis revealed a novel regulatory network of GAS5/miR-18a-5p/serine/threonine kinase 4 (STK4) that inhibits epithelial-to-mesenchymal transition (EMT) and enhances tumor stem cell-like-mediated sensitivity to paclitaxel in PCa. +other 35294699 hsa-mir-22 Triple Negative Breast Neoplasms PURPOSE: Downregulation of miRNA-22 in triple-negative breast cancer (TNBC) is associated with upregulation of eukaryotic elongation 2 factor kinase (eEF2K) protein, which regulates tumor growth, chemoresistance, and tumor immunosurveillance. More importantly, drug synergy was identified between miRNA-22 and standard-of-care drugs against TNBC, providing a basis for rational therapeutic combinations for improved response CONCLUSIONS: The present study highlights the translational potential of miRNA-22 nanotherapy for TNBC in combination with standard-of-care drugs. +lncRNA target 35294601 hsa-mir-155 Depression Collectively, these findings suggested that SM exerted antidepressant actions by targeting the miRNA +lncRNA target 35294329 hsa-mir-107 Squamous Cell Carcinoma of Head and Neck The above findings revealed that miR-107 could suppress FaDu cell proliferation, migration, invasion and induced apoptosis by targeting NOB1 through the PI3K/Akt pathway, suggesting that miR-107/NOB1 axis may exert a key role in FaDu HSCC development. +exosome 35294195 hsa-mir-155 Diabetes Mellitus inhibitor-loaded MSC-derived exosomes in diabetic wound healing and opened the doors for encapsulating miRNAs along with antibiotics within the MSC-derived exosomes toward improved management of chronic, nonhealing diabetic wounds. +genetics_knock down_suppress 35293807 hsa-mir-30 psoriasis 1 CONCLUSION: Circ_0060531 knockdown assuaged IL +lncRNA target 35293774 hsa-mir-10a Porcine Reproductive and Respiratory Syndrome Our previous work has indicated that the expression level of miR-10a increased in porcine alveolar macrophages (PAMs) during porcine reproductive and respiratory syndrome virus (PRRSV) infection and further inhibited viral replication through downregulates the expression of host molecule signal-recognition particle 14 (SRP14) protein. +transcription factor target 35293661 hsa-mir-146a Prostatic Neoplasms A dual luciferase reporter gene assay identified the regulatory relationship between APIP and miR-146a-3p in prostate cancer, suggesting that APIP is a direct target of miR-146a-3p. miR-146a-3p reduced cell proliferation and migration in prostate cancer. +genetics_GWAS 35293603 hsa-mir-423 Diabetes Mellitus, Type 2 In the present study, the association of the single nucleotide polymorphisms (SNPs) in the GCK, MIR196A2 and MIR423 genes with susceptibility to T2DM in patients from two regions of Saudi Arabia were examined, using the tetraprimer amplification refractory mutation system. +therapeutic target 35293593 hsa-mir-218 Osteosarcoma miR-218 targets multiple oncogenes and is a therapeutic target for osteosarcoma. +transcription factor target 35293311 hsa-mir-122 Sepsis Mannan binding lectin serine peptidase 1(MASP1) was a direct target gene of miR5p, and levels of MASP1, C3, and C4 were all significantly lower in the sepsis with disseminated intravascular coagulopathy (DIC) group than in the sepsis without DIC group. +other 35293311 hsa-mir-122 Blood Coagulation Disorders MiR5p is a diagnostic and prognostic biomarker of sepsis and is correlated with coagulation abnormalities in sepsis. +transcription factor target 35293311 hsa-mir-122 Disseminated Intravascular Coagulation Mannan binding lectin serine peptidase 1(MASP1) was a direct target gene of miR5p, and levels of MASP1, C3, and C4 were all significantly lower in the sepsis with disseminated intravascular coagulopathy (DIC) group than in the sepsis without DIC group. +genetics_knock down_suppress 35293286 hsa-mir-455 Carcinoma, Hepatocellular In conclusion, HCC cell proliferation, invasion, and migration were restrained by knockdown of HUMT, which was related to the miR +transcription factor target 35293283 hsa-mir-26b Urinary Bladder Neoplasms MI significantly suppressed the proliferation, colony formation, invasion, and migration and induced apoptosis of human bladder cancer cells, and MI significantly increased miR-26b expression. Overall, MI showed a potent anti-tumor effect against bladder cancer partially via modulating the miR-26b/Nox4 axis. +circRNA target 35293280 hsa-mir-585 Carcinoma, Non-Small-Cell Lung Our study demonstrated that silencing of circ_0002360 enhanced the Taxol sensitivity and suppressed the malignant behaviors of Taxol-resistant NSCLC cells by miR +other 35293246 hsa-mir-26a Obesity Moreover, a different expression of miR-26a and miR-338 in the obese group was found. +other 35293246 hsa-mir-338 Obesity Moreover, a different expression of miR-26a and miR-338 in the obese group was found. +genetics_knock down_promote 35293097 hsa-mir-106a Nasopharyngeal Carcinoma Exosomal miR-106a-5p could enter NPC cells, and its overexpression promoted the proliferation, migration, invasion, and metastasis of NPC cells, which were suppressed by knockdown of exosomal miR-106a-5p. +genetics_knock down_suppress 35293026 hsa-mir-411 Carcinoma, Hepatocellular MATERIAL AND METHODS: The expression of SLC16A1-AS1 and miR-411 was examined in clinical HCC tissues. In addition, SLC16A1-AS1 knockdown and miR-411 overexpression significantly stagnated the progression of HCC cells. +circulation_biomarker_prognosis_up 35292840 hsa-mir-370 Colorectal Neoplasms CONCLUSION: Our data suggest that miR-370 with its clear expression in plasma samples may be a potential diagnostic marker to determine the severity of the disease in patients at a later stage of colorectal cancer. +other 35292776 hsa-mir-124 Spinal Cord Injuries There is a strong positive correlation between miRNA-124, miRNA-544a, and acute spinal cord injury. +other 35292776 hsa-mir-544a Spinal Cord Injuries There is a strong positive correlation between miRNA-124, miRNA-544a, and acute spinal cord injury. +other 35292776 hsa-mir-124 Ischemic Stroke There is a strong positive correlation between miRNA-124, miRNA-544a, and acute spinal cord injury. +other 35292776 hsa-mir-544a Ischemic Stroke There is a strong positive correlation between miRNA-124, miRNA-544a, and acute spinal cord injury. +genetics_overexpression_promote 35292240 hsa-mir-335 Osteoporosis-pseudoglioma syndrome In vivo experiments also found that overexpression of miR +other 35292022 hsa-mir-199a Small Cell Lung Carcinoma CONCLUSIONS: The regulation of autophagy by the miR-199a-5p/p62 axis was a potential mechanism of small cell lung cancer cisplatin resistance. +lncRNA target 35291921 hsa-mir-26b Carcinoma, Hepatocellular In conclusion, our results demonstrated that HAGLROS contributed to the malignant progression of HCC via serving as a sponge for miR-26b-5p to facilitate KPNA2 expression and inactivate p53 signaling. Targeting HAGLROS/miR-26b-5p/KPNA2 axis might be an alternative therapeutic strategy for HCC patients. +exosome 35291915 hsa-mir-93 Norrie disease In summary, our study demonstrated that M2 macrophage-secreted exosomes attenuated LPS-induced podocyte apoptosis by regulating the miR5p/TLR4 axis, which provides a new perspective for the treatment of patients with DN. +genetics_knock down_suppress 35291714 hsa-mir-338 Acute Lung Injury Overall, circ_0001679 knockdown inhibits sepsis-induced ALI progression through the miR3p/DUSP16 axis. +lncRNA target 35291619 hsa-mir-124a Arthritis, Rheumatoid Targeting circHIPK3 and microRNA-124a, and their downstream adaptor molecules, poses a new challenge for RA therapy. +circulation_biomarker_diagnosis_up 35291612 hsa-mir-374 Colorectal Neoplasms This study investigated the effect of radiotherapy on miR-374 expression, and APC and GSK-3beta, two of its target genes, in the WNT pathway, in peripheral blood samples from radiotherapy-treated colorectal cancer (CRC) patients. RESULTS: Quantitative RT-PCR revealed significant down-regulation of miR-374 (0.63-fold) and up-regulation of APC (1.12-fold) and GSK-3beta (1.22-fold) in CRC patients after five weeks of radiotherapy. +circulation_biomarker_diagnosis_up 35290882 hsa-mir-155 Lung Neoplasms For practical applications, we prepared a multiplexed array sensor to simultaneously detect four exo-miRNAs (miRNA-21, miRNA-155, miRNA-205, and miRNA-let-7b) up to femtomolar levels from 1.0 mL to 125 muL of cell culture (A549, MCF-7 and BEAS-2B) media and lung cancer patient serum samples, respectively. +circulation_biomarker_diagnosis_up 35290882 hsa-mir-21 Lung Neoplasms For practical applications, we prepared a multiplexed array sensor to simultaneously detect four exo-miRNAs (miRNA-21, miRNA-155, miRNA-205, and miRNA-let-7b) up to femtomolar levels from 1.0 mL to 125 muL of cell culture (A549, MCF-7 and BEAS-2B) media and lung cancer patient serum samples, respectively. +circulation_biomarker_diagnosis_up 35290882 hsa-mir-205 Lung Neoplasms For practical applications, we prepared a multiplexed array sensor to simultaneously detect four exo-miRNAs (miRNA-21, miRNA-155, miRNA-205, and miRNA-let-7b) up to femtomolar levels from 1.0 mL to 125 muL of cell culture (A549, MCF-7 and BEAS-2B) media and lung cancer patient serum samples, respectively. +circulation_biomarker_diagnosis_up 35290882 hsa-let-7b Lung Neoplasms For practical applications, we prepared a multiplexed array sensor to simultaneously detect four exo-miRNAs (miRNA-21, miRNA-155, miRNA-205, and miRNA-let-7b) up to femtomolar levels from 1.0 mL to 125 muL of cell culture (A549, MCF-7 and BEAS-2B) media and lung cancer patient serum samples, respectively. +lncRNA target 35290861 hsa-mir-124 Canine Mammary Carcinoma In conclusion, miR-124 regulates CMC tumor growth and EMT by targeting CDH2, maybe a potential therapeutic strategy against CMC. +transcription factor target 35289984 hsa-mir-221 Obesity, Abdominal CONCLUSIONS: Bioinformatic analysis evidenced that miR3p participates in several obesity-related pathways, and more interestingly, this miRNA targets several candidate genes to childhood obesity according to DisGeNet database. +exosome 35289974 hsa-mir-155 Diabetic Nephropathies AIM: Evaluate the expression of exomiRs-126, -146, and -155 in urinary exosomes of patients with T2DM and diabetic kidney disease to establish a predictive classification model with exomiRs and clinical variables in order to determine their contribution to DKD. +other 35289974 hsa-mir-126 Diabetic Nephropathies In addition, T2DM patients with albuminuria presented a significant increase in miR-126 contrasted to controls and patients without albuminuria. +exosome 35289974 hsa-mir-146 Diabetic Nephropathies AIM: Evaluate the expression of exomiRs-126, -146, and -155 in urinary exosomes of patients with T2DM and diabetic kidney disease to establish a predictive classification model with exomiRs and clinical variables in order to determine their contribution to DKD. +other 35289769 hsa-mir-182 Depression miR-182 was poorly expressed in patients with CHD. Our results demonstrated that HDAC1 repressed miR-182 and activated the TGF-beta/Smad pathway to promote CHD. +genetics_knock down_promote 35289739 hsa-mir-193a Lung Neoplasms Circ_0048856 knockdown suppressed tumor growth and reduced DDP resistance in lung cancer by miR-193a-5p/ABCC1 or miR +genetics_knock down_promote 35289739 hsa-mir-98 Lung Neoplasms Circ_0048856 knockdown suppressed tumor growth and reduced DDP resistance in lung cancer by miR-193a-5p/ABCC1 or miR +other 35289275 hsa-mir-134 Carcinoma, Renal Cell VEGFA, FLT1, EGLN3, DLL4, and miR5p may be novel biomarkers for RCC. +other 35289243 hsa-mir-1290 Esophageal Squamous Cell Carcinoma As a result, circCDR1 was low-expressed in ESCC tissues and cells, while miR-1290 was high-expressed. Collectively, circCDR1 sponged miR-1290 to regulate the progression of ESCC both in vitro and in vivo. +genetics_overexpression_suppress 35288979 hsa-mir-197 Colorectal Neoplasms Similarly, overexpression of PFKFB3 can regulate CRC cell behavior and 5-FU resistance caused by miR +exosome 35288625 hsa-mir-143 Polycystic Ovary Syndrome 3p-containing exosomes derived from PCOS follicular fluid promoted granulosa cell apoptosis by targeting BMPR1A and blocking the Smad1/5/8 signaling pathway. +circRNA target 35288538 hsa-mir-766 Pancreatic Carcinoma In conclusion, our results demonstrated that circATG7 accelerates PC progression via miR5p/ATG7 and that HUR/ATG7 depends on autophagic flux. +circulation_biomarker_diagnosis_down 35288364 hsa-mir-210 Peripheral Arterial Disease Previous studies have demonstrated that circulating microRNA (miR)-210 levels are elevated in peripheral artery disease (PAD) patients. +exosome 35288170 hsa-mir-127 Choriocarcinoma This research aimed to study the effects of miR3p-enriched EVs (EV-miR3p) on CC and underlying mechanisms. RESULTS: The expression of miR3p was downregulated, while that of ITGA6 was upregulated in CC cell lines. EV-miR3p could inhibit the proliferation, invasion, migration, and promote the apoptosis of CC cells. We observed that EV-miR3p suppressed EMT of CC cells by targeting ITGA6. CONCLUSION: These results indicate that EV-miR3p from hUCMSCs exhibits anti-tumor effects by targeting ITGA6, which may be used as a novel therapeutic strategy for CC treatment. +genetics_overexpression_promote 35287604 hsa-mir-335 Carcinoma, Hepatocellular 5p overexpression partly counteracted the effect of circ_0064288 overexpression on HCC cells. +other 35287556 hsa-let-7a Stomach Neoplasms In conclusion, TTTY15 promotes GC progression, by regulating the let-7a-5p/Wnt1 axis to activate the Wnt/beta-catenin pathway. +genetics_overexpression_suppress 35287547 hsa-mir-3200 Glioma 3p, and CAMK2A overexpression reversed the anticancer roles of miR +genetics_knock down_promote 35287543 hsa-mir-1296 Carcinoma, Non-Small-Cell Lung Furthermore, SIX1 overexpression counteracted the inhibiting impact of miR +genetics_overexpression_promote 35287147 hsa-mir-20a Hypoxia-Ischemia, Brain Besides, overexpressed MAT2B reversed the effect of overexpressed miR-20a-5p on the levels of MAT2B, Bcl-2 and Bax, brain tissue damage, as well as the learning and memory abilities in rats with HIBD. +circulation_biomarker_diagnosis_ns 35286944 hsa-mir-155 Breast Neoplasms Based on this consistency, two circulating miRNA markers for breast cancer (miR-21 and miR-155) were used as the SERS diagnostic target. +circulation_biomarker_diagnosis_ns 35286944 hsa-mir-21 Breast Neoplasms Based on this consistency, two circulating miRNA markers for breast cancer (miR-21 and miR-155) were used as the SERS diagnostic target. +transcription factor target 35286917 hsa-mir-34a Nephritis, Interstitial miR-34a mimic inhibits Foxp3 expression via targeting 3' untranslated region (3'UTR) whereas its inhibitor promotes Foxp3 expression in vitro. +other 35286916 hsa-mir-149 Aortic Aneurysm, Abdominal Then, we constructed ceRNA network of circRNA-miRNA-mRNA (IL-6/CCL2/NF-kappaB) in AAA and found that hsa_circ_0087352 promotes IL-6 transcription and the secretion of inflammatory cytokines by sponging endogenous hsa-miR5p in macrophages. +circulation_biomarker_diagnosis_ns 35286868 hsa-mir-124 Acute Kidney Injury We also found that in the serum of SA-AKI patients, LPCAT3 activity was increased, and miR +circulation_biomarker_diagnosis_ns 35286626 hsa-mir-101 Atherosclerosis In summary, these data indicate that CTRP15 inhibits the development of atherosclerosis by enhancing RCT efficiency and increasing plasma HDL-C levels via the T-cadherin/miR3p/ABCA1 pathway. +genetics_overexpression_promote 35286539 hsa-mir-181a Osteoarthritis OPN overexpression exerted opposite effects on OA chondrocytes and significantly attenuated the roles of miR-181a-5p overexpression in OA chondrocytes. +transcription factor target 35286466 hsa-mir-625 Amyotrophic Lateral Sclerosis We also assayed the expression profile of these miRNAs in the cerebrospinal fluid (CSF) of familial (fALS) and sporadic patients (sALS) and we identified a significant dysregulation of miR-34a-3p and miR3p levels in ALS compared to controls. +transcription factor target 35286466 hsa-mir-34a Amyotrophic Lateral Sclerosis We also assayed the expression profile of these miRNAs in the cerebrospinal fluid (CSF) of familial (fALS) and sporadic patients (sALS) and we identified a significant dysregulation of miR-34a-3p and miR3p levels in ALS compared to controls. +genetics_overexpression_promote 35286011 hsa-mir-455 Carcinoma, Hepatocellular And overexpression of miR +circRNA target 35285770 hsa-mir-1 Diabetic Nephropathies CONCLUSION: In summary, our data showed that hsa_circ_0037128 could promote HG-induced podocytes injury via regulating miR5p/KLF9 axis, showing that hsa_circ_0037128 might be a target for DN treatment. +transcription factor target 35285580 hsa-mir-7114 Colorectal Neoplasms 5p pairs play an important role in early CRC development, and may help identify potential molecular targets for early detection of CRC. +transcription factor target 35285580 hsa-mir-6780 Colorectal Neoplasms 5p pairs play an important role in early CRC development, and may help identify potential molecular targets for early detection of CRC. +exosome 35285412 hsa-mir-106a Lymphoma Lymphoma cell-derived extracellular vesicles inhibit autophagy and apoptosis to promote lymphoma cell growth via the microRNA-106a/Beclin1 axis. +other 35285410 hsa-mir-1294 Carcinoma, Renal Cell Furthermore, we identified a novel circZKSCAN1/miR-1294/PIM1 axis was identified in RCC progression, showing that the expression of circZKSCAN1 expression in RCC cells was transcriptionally regulated by Kruppel-like factor 2. +lncRNA target 35285389 hsa-mir-582 Osteoporosis 3p may be a therapeutic target of osteoporosis treatment. +other 35285386 hsa-mir-106a Hypertension 5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension. +other 35285386 hsa-mir-20b Alzheimer Disease 5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension. +other 35285386 hsa-mir-15b Alzheimer Disease 5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension. +other 35285386 hsa-mir-20a Hypertension 5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension. +other 35285386 hsa-mir-15a Hypertension 5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension. +other 35285386 hsa-mir-106a Alzheimer Disease 5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension. +other 35285386 hsa-mir-16 Alzheimer Disease 5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension. +other 35285386 hsa-mir-15a Alzheimer Disease 5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension. +other 35285386 hsa-mir-20a Alzheimer Disease 5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension. +other 35285386 hsa-mir-20b Hypertension 5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension. +other 35285386 hsa-mir-195 Hypertension 5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension. +other 35285386 hsa-mir-92a Hypertension 5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension. +other 35285386 hsa-mir-92a Alzheimer Disease 5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension. +other 35285386 hsa-mir-15b Hypertension 5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension. +other 35285386 hsa-mir-16 Hypertension 5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension. +other 35285386 hsa-mir-195 Alzheimer Disease 5p, hsa-miR-92a-3p as widely involved in platelet reactivity and associated diseases, including CVDs, Alzheimer's and cerebrovascular diseases, cancer and hypertension. +genetics_knock down_promote 35285372 hsa-mir-1287 Retinoblastoma 5p, thus acting as a contributor to RB carcinogenesis.HighlightsCirc_0075804 is overexpressed in RB.Circ_0075804 knockdown inhibits RB cell malignant phenotypes and tumor growth in vivo.Circ_0075804 regulates RB cell behaviors by targeting miR +genetics_knock down_promote 35284960 hsa-mir-876 Triple Negative Breast Neoplasms 3p was confirmed as a target of circ_0062558, and circ_0062558 knockdown repressed TNBC cell malignant behaviors by increasing miR +transcription factor target 35284668 hsa-mir-20a Colorectal Neoplasms In vitro assays demonstrated that elevated miR-20a up-regulated FA synthesis enzymes via Wnt/beta-catenin signaling, and finally promoted proliferative and migration of metabolic CRC cells. +lncRNA target 35284630 hsa-mir-548i Carcinoma, Non-Small-Cell Lung Mechanistically, circ0001666 could act as a sponge to miR-1184/miR-548I and upregulate the expression of AGO1, thereby promoting the activation of the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR signaling pathway in NSCLC cells. Collectively, these findings demonstrated that circ0001666 could serve as an oncogene to promote the migration and invasion of NSCLC via a novel miR-1184/miR-548I/AGO1 axis, which might be a promising therapeutic target for NSCLC treatment. +lncRNA target 35284630 hsa-mir-1184 Carcinoma, Non-Small-Cell Lung Mechanistically, circ0001666 could act as a sponge to miR-1184/miR-548I and upregulate the expression of AGO1, thereby promoting the activation of the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR signaling pathway in NSCLC cells. Collectively, these findings demonstrated that circ0001666 could serve as an oncogene to promote the migration and invasion of NSCLC via a novel miR-1184/miR-548I/AGO1 axis, which might be a promising therapeutic target for NSCLC treatment. +circulation_biomarker_diagnosis_up 35284624 hsa-mir-205 Nasopharyngeal Carcinoma We found that up-regulated serum exosomal miR +lncRNA target 35284500 hsa-mir-762 Myocardial Infarction In addition, bioinformatics analysis, luciferase activity, and western blot assay proved UCP2 was a direct target gene of microRNA-762, a up-regulated microRNA after MI. In conclusion, UCP2 plays a protective role after MI and the mechanism is involved in microRNA-762 upstream and DRP1-dependent mitochondrial fission downstream. +other 35284413 hsa-mir-212 Cartilage Diseases Excessive chondrocyte degeneration and inflammation are the pathological features of osteoarthritis (OA), and altered miR5p may contribute to meniscus and cartilage degeneration. +other 35284413 hsa-mir-212 Inflammation Excessive chondrocyte degeneration and inflammation are the pathological features of osteoarthritis (OA), and altered miR5p may contribute to meniscus and cartilage degeneration. +transcription factor target 35284238 hsa-mir-203a Pericardial Effusion Embryos treated with the miR-203a inhibitor and Phe exhibited a reduced heart rate by 48 h post fertilization (hpf), with an increased incidence of developmental deformities (including pericardial edema, altered eye development, and spinal deformities) and reduced caudal fin length by 72 hpf. +transcription factor target 35284238 hsa-mir-203a Spinal Diseases Embryos treated with the miR-203a inhibitor and Phe exhibited a reduced heart rate by 48 h post fertilization (hpf), with an increased incidence of developmental deformities (including pericardial edema, altered eye development, and spinal deformities) and reduced caudal fin length by 72 hpf. +other 35284238 hsa-mir-203a Cardiovascular Diseases Early studies evaluating the effects of oil on developmental toxicity in early life stages of fish showed that reductions in expression of miR-203a were associated with enhanced expression of downstream mRNAs that predicted altered eye development, cardiovascular disease, and improper fin development. +target gene 35284123 hsa-mir-448 Carcinoma, Hepatocellular MiR-448 suppresses cell proliferation and glycolysis of hepatocellular carcinoma through inhibiting IGF-1R expression. +lncRNA target 35284121 hsa-mir-17 Colorectal Neoplasms Finally, we determined that the dysregulation of lncRNAs, such as HCG16, CASC9, SNHG16, HAND2-AS1, and NR2F1-AS1, secluded altered the expression of several miRNAs, such as hsa-miR-193a-5p, hsa-miR +lncRNA target 35284121 hsa-mir-193a Colorectal Neoplasms Finally, we determined that the dysregulation of lncRNAs, such as HCG16, CASC9, SNHG16, HAND2-AS1, and NR2F1-AS1, secluded altered the expression of several miRNAs, such as hsa-miR-193a-5p, hsa-miR +lncRNA target 35284121 hsa-mir-92a Colorectal Neoplasms Finally, we determined that the dysregulation of lncRNAs, such as HCG16, CASC9, SNHG16, HAND2-AS1, and NR2F1-AS1, secluded altered the expression of several miRNAs, such as hsa-miR-193a-5p, hsa-miR +lncRNA target 35284121 hsa-mir-485 Colorectal Neoplasms Finally, we determined that the dysregulation of lncRNAs, such as HCG16, CASC9, SNHG16, HAND2-AS1, and NR2F1-AS1, secluded altered the expression of several miRNAs, such as hsa-miR-193a-5p, hsa-miR +other 35283744 hsa-mir-128 Nondisjunction, Genetic By analogy, reducing miR-128 could enhance the capacity to learn to speak in patients with non-verbal ASD. +transcription factor target 35283744 hsa-mir-128 Heart Septal Defects, Atrial By analogy, reducing miR-128 could enhance the capacity to learn to speak in patients with non-verbal ASD. To our knowledge, this study is the first to directly link miR-128 to learned vocal communication and provides support for miR-128 as a potential therapeutic target for ASD. +genetics_overexpression_promote 35283536 hsa-mir-1 psoriasis 1 CONCLUSIONS: Our findings indicate that overexpression of miR-31 causes upregulation of STAT3, which further brings about upregulation of p53, and eventually leads to serious psoriasis skin lesion. +lncRNA target 35283358 hsa-mir-181a Inflammation Thus, we evaluated the effects of miR-181a-5p on inflammation in PC12 cells and the underlying mechanism in play. Upregulation of miR-181a-5p (via transfection) inhibited inflammation of, and HMGB1 expression by, LPS-induced PC12 cells. +transcription factor target 35283358 hsa-mir-181a Spinal Cord Injuries CONCLUSIONS: miR-181a-5p attenuated the inflammatory response of LPS-induced PC12 cells by directly inhibiting HMGB1; thus, miR-181a-5p may serve as a therapeutic target in SCI. +genetics_knock down_promote 35283197 hsa-mir-16 Breast Neoplasms Knockdown of EPHA1 or inhibition of NF-kappaB signaling reversed the effects of down-regulated miR +other 35283179 hsa-mir-484 Mental Disorders 3p). +other 35283179 hsa-mir-106b Mental Disorders 3p). +other 35283179 hsa-mir-33a Mental Disorders 3p). +other 35283179 hsa-mir-24 Mental Disorders 3p). +other 35283179 hsa-mir-25 Mental Disorders 3p). +other 35282774 hsa-mir-150 Osteoporosis-pseudoglioma syndrome Compared with controls, the expression of MIAT was significantly increased, whereas that of miR5p was markedly decreased in patients with OP. +lncRNA target 35282764 hsa-mir-874 Stomach Neoplasms 3p downregulation on GDPD5 expression, viability, migration and invasion of DDP-resistant GC cells. +lncRNA target 35282648 hsa-mir-423 Essential Hypertension CONCLUSION: FENDRR played an energetic role in EH and contributed to HUVECs dysfunction by restricting cell proliferation, suppressing cell migration, and accelerating cell apoptosis by manipulating the miR +other 35282644 hsa-mir-22 Carcinoma, Hepatocellular 3p were identified as the most promising RRM1 upstream ncRNA-related pathways in HCC. +other 35282644 hsa-mir-4435-2 Carcinoma, Hepatocellular 3p were identified as the most promising RRM1 upstream ncRNA-related pathways in HCC. +genetics_GWAS 35282462 hsa-mir-21 Thyroid Cancer, Papillary 5p) were substantially overexpressed in the hobnail variant. +genetics_GWAS 35282462 hsa-mir-146b Thyroid Cancer, Papillary 5p) were substantially overexpressed in the hobnail variant. +other 35282268 hsa-mir-34c Crohn Disease CONCLUSION: By constructing a ceRNA network with lncRNA-miRNA-mRNA, PCR verification, and KEGG analysis, we revealed that LOC102550026/miRNA-34c-5p/Pck1 axis and adipocytokine, PPAR, AMPK, FoxO, and PI3K-Akt signaling pathways might regulate the intestinal immune-inflammatory response, and HPM may regulate the lncRNA LOC102550026/miR-34c-5p/Pck1 axis and adipocytokine, PPAR, AMPK, FoxO, and PI3K-Akt signaling pathways, thus improving intestinal inflammation in CD. +transcription factor target 35282137 hsa-mir-26a Fractures, Bone Therefore, we propose that targeting miR-26a may be a novel therapeutic method for bone regeneration and treating fractures. +lncRNA target 35282101 hsa-mir-100 Uterine Cervical Neoplasms 3p is an inhibiting factor and miR +lncRNA target 35282101 hsa-mir-142 Uterine Cervical Neoplasms 3p is an inhibiting factor and miR +lncRNA target 35282018 hsa-mir-335 Mucocutaneous Lymph Node Syndrome CONCLUSIONS: Together, these results indicated that lncRNA Slco4a1 could regulate the progression of HUVECs in KD by targeting the miR5p/POU5F1 axis, providing new insights for KD treatment. +genetics_overexpression_suppress 35281946 hsa-mir-448 Glioblastoma Furthermore, overexpression of ROCK1 abolished the antitumor effect of miR-448 in GBM. +lncRNA target 35281864 hsa-mir-497 Glioblastoma 5p-RSPO2 axis controls Wnt/beta-catenin signaling and plays a function in GBM carcinogenesis, suggesting that it may be a therapeutic target to reduce GBM growth, as shown by our research findings. +other 35281863 hsa-mir-27b Stomach Neoplasms However, down-regulated miR-27b-3p could reverse the effects of weakenTP73-AS1 on the progression of GC. Conclusion: TP73-AS1 promoted GC proliferation, migration, and invasion by sponging miR-27b-3p to regulate TMED5. +target gene 35281858 hsa-mir-137 Lung Neoplasms LncRNA LASTR promote lung cancer progression through the miR-137/TGFA/PI3K/AKT axis through integration analysis. +target gene 35281849 hsa-mir-152 Ovarian Neoplasms CircATRNL1 and circZNF608 Inhibit Ovarian Cancer by Sequestering miR-152-5p and Encoding Protein. +genetics_GWAS 35281840 hsa-mir-27a Esophageal Neoplasms Furthermore, many biological functions and pathways related to immunity and ferroptosis were enriched in the high-risk group, and the role of the TMEM161B-AS1/hsa-miR-27a-3p/GCH1 network in ESCA is supported. Biological processes related to immune functions, KMT2D mutation, CNV and the TMEM161B-AS1/hsa-miR-27a-3p/GCH1 network were involved in ESCA progression. +lncRNA target 35281537 hsa-mir-665 Acute Kidney Injury We revealed that miR-665 expression was increased in septic AKI, and silencing miR-665 could inhibit LPS-induced inflammation and apoptosis of the kidney by targeting Bcl-2, thereby improving renal function. +lncRNA target 35281530 hsa-mir-145 Squamous Cell Carcinoma of Head and Neck 5p was a key downstream target inducing the oncogenic role of SNHG1 in the OSCC process with KLF5 as its downstream gene. +lncRNA target 35281529 hsa-mir-1305 Lung Neoplasms This paper aims to explore the lncRNA PROX1-AS1 effect on proliferation, migration, invasion, and apoptosis of lung cancer cells together with its targeted regulation on miR-1305. +genetics_knock down_promote 35281523 hsa-mir-107 Ovarian Neoplasms The luciferase reporter assay proved overexpression of LINC-DUBR repressed cells proliferation and invasion via binding to miR-107 in ovarian cancer. +genetics_overexpression_promote 35281474 hsa-mir-877 Osteosarcoma 3p downregulation or CREBBP overexpression partly inverted the inhibitory effect of EVs by silencing NORAD on OS cell proliferation, invasion, migration, and angiogenesis. +lncRNA target 35281083 hsa-mir-381 Retinal Degeneration Taken together, our study demonstrated that miR3p regulated RPCs proliferation and differentiation by targeting Hes1, which provides an experimental basis of RPCs transplantation therapy for retinal degeneration. +other 35281074 hsa-mir-155 Arthritis, Rheumatoid INTRODUCTION: We previously reported a specific defect of rheumatoid arthritis (RA) monocyte polarization to anti-inflammatory M2-like macrophages related to increased miR-155 expression in all RA patients except those receiving adalimumab (ADA). +other 35281056 hsa-mir-218 DiGeorge Syndrome We report miR5p upregulation in KP-EV of kidney transplant recipients with DGF. +other 35280778 hsa-mir-485 Stomach Neoplasms 3p-LYN-neurons. +other 35280778 hsa-mir-1269b Stomach Neoplasms 3p-LYN-neurons. +other 35280778 hsa-mir-3686 Stomach Neoplasms 3p-LYN-neurons. +other 35280778 hsa-mir-5584 Stomach Neoplasms 3p-LYN-neurons. +other 35280778 hsa-mir-145 Stomach Neoplasms 3p-LYN-neurons. +other 35280778 hsa-mir-4537 Stomach Neoplasms 3p-LYN-neurons. +lncRNA target 35280693 hsa-mir-186 Colonic Neoplasms Our study revealed that M2-EVs facilitates the growth and motility of CC cells by delivering the enclosed miR5p, which directly targets DLC1 mRNAs and facilitates their degradation, which could provide a potential biomarker and therapeutic target for CC. +circRNA target 35280687 hsa-mir-412 Carcinoma, Renal Cell 3p/PCDH7 axis, and suggest that circDVL1 could be a novel diagnostic and prognositc marker and therapeutic target for ccRCC. +lncRNA target 35280407 hsa-mir-874 Intervertebral Disc Degeneration 3p can inhibit the cell death of IDD, and not only participate in caspase-3 and Fas-associating protein with a novel death domain (FADD)-mediated apoptosis through targeted regulation of exogenous MMP2/MMP3 pathway, but also play a role in cell apoptosis through mitochondrial pathway. +lncRNA target 35280401 hsa-mir-199b Melanoma MiR-199b is a target gene of SNHG12, which was expressed at low levels in melanoma cell lines, and SNHG12 regulated melanoma cell proliferation, migration, and invasion through miR-199b. CONCLUSIONS: SNHG12 is highly expressed in melanoma, and promotes the expression of ETS1, PXN, JAG1, and DDR1 through targeted regulation of miR-199b, thereby promoting the proliferation, migration, and invasion of melanoma cells. +circulation_biomarker_diagnosis_ns 35280383 hsa-mir-93 Breast Neoplasms 5p directly targets the PD-L1/CCND1 signaling pathway to influence their accumulation and distribution in the cell membrane, nucleus, and cytoplasm, mediating tumor progression and immune regulation in BRCA. +lncRNA target 35280029 hsa-mir-3907 Meibomian Gland Carcinoma miR-3907 over-expression, miR-3907 knock-down, target gene knock-down and miR-3907 knock-down with target gene knock-down were respectively performed in MGC cell. +lncRNA target 35279965 hsa-mir-337 Uterine Cervical Neoplasms CONCLUSION: Circ_0000228 up-modulates TGFBR1 by targeting miR +target gene 35279963 hsa-mir-625 Leukemia, Myeloid, Acute Upregulation of hsa-miR-625-5p Inhibits Invasion of Acute Myeloid Leukemia Cancer Cells through ILK/AKT Pathway. +other 35279909 hsa-mir-486 Kidney Diseases miR5p is implicated in cisplatin-induced kidney damage in vivo. +circRNA target 35279761 hsa-mir-129-2 Breast Neoplasms Silencing of circ-TFF1 inhibited the malignant behavior of BC cells by releasing miR +lncRNA target 35279660 hsa-mir-590 Glioma CONCLUSIONS: HCG11 suppresses glioma cells proliferation and migration through regulating the miR +other 35279605 hsa-mir-21 Intrahepatic Cholestasis of Pregnancy CONCLUSION: Circ_0060731 mediated miR5p-PDCD4/ESR1 pathway could induce apoptosis of placental trophoblasts in intrahepatic cholestasis of pregnancy. +lncRNA target 35279586 hsa-mir-124 late onset Parkinson's disease In conclusion, SOS1-IT1 regulated the miR3p/PTEN/AKT/mTOR pathway to participate in the regulation of MPP(+)-induced neuronal cell injury, indicating the SOS1-IT1 might be an effective therapeutic target for PD. +lncRNA target 35279480 hsa-mir-664b Pancreatic Carcinoma Quantitative reverse transcription (qRTPCR) was used to measure the expression levels of HOXD-AS1, miR-664b-3p, and PLAC8. In conclusion, HOXD-AS1 was upregulated in PC tissues, promoting the proliferation, invasion, and migration of PC cells via the miR-664b-3p/PLAC8 axis. +other 35279460 hsa-mir-9 Anemia, Refractory, with Excess of Blasts Furthermore, NFATC2 upregulated the phosphorylation of p65, thus activating the NF-kappaB pathway in RIOM; while miR3p reduced this effect. +genetics_knock down_promote 35279406 hsa-mir-197 Breast Neoplasms Knockdown of miR-197 or activation of PPARG in BCSCs-EVs-treated cells significantly counteracted the promoting effect of BCSCs-EVs on BC cell growth and metastasis. +exosome 35279183 hsa-mir-21 Atherosclerosis CONCLUSIONS: Our study demonstrated that ECFC-exosomes protect against atherosclerosis- or PTCA-induced vascular injury by rescuing autophagic flux and inhibiting SIAP1L2 expression through delivery of miR5p. +lncRNA target 35279164 hsa-mir-206 Intervertebral Disc Degeneration These data suggested that miR-206/GJA1 might be potential therapeutic targets for IDD. +circRNA target 35279159 hsa-mir-186 Osteosarcoma CONCLUSIONS: Abnormally high expression of circ_0001174 may promote the proliferation, migration, and invasion of OS cells through up-regulating MACC1 by sponging miR5p. +target gene 35279146 hsa-mir-149 Triple Negative Breast Neoplasms LRP11-AS1 promotes the proliferation and migration of triple negative breast cancer cells via the miR-149-3p/NRP2 axis. +lncRNA target 35279145 hsa-mir-100 Colorectal Neoplasms CONCLUSIONS: MIR100HG and hnRNPA2B1 interact to control the transcriptional activity of Wnt signaling in CRC via regulation of TCF7L2 mRNA stability. +circulation_biomarker_diagnosis_down 35279129 hsa-mir-133a Sepsis Pearson's correlation coefficient analysis was utilized to analyze the correlation between circFADS2 and miR-133a levels across plasma samples from sepsis patients. +transcription factor target 35279083 hsa-mir-20a Pulmonary Fibrosis CONCLUSIONS: Our findings suggest that ALKBH5 promotes silica-induced lung fibrosis via the miR-320a-3p/FOXM1 axis or targeting FOXM1 directly. +genetics_overexpression_promote 35278814 hsa-mir-532 Colon Adenocarcinoma Overexpression of FJX1 could stimulate cell malignant behaviors of colon adenocarcinoma, whereas forced expression of miR +lncRNA target 35278613 hsa-mir-146a Urinary Bladder Neoplasms Moreover, METTL3/miR-146a-5p/NUMB/NOTCH2 axis plays an oncogenic role in bladder cancer pathogenesis and could be a potential therapeutic target for recurrent bladder cancer treatment. +circulation_biomarker_diagnosis_ns 35278480 hsa-mir-431 Alzheimer Disease CONCLUSION: Our findings establish circ_0002945 as a crucial regulator of Abeta-induced neuron apoptosis and endoplasmic reticulum stress and uncover a novel circ_0002945/miR5p/TNFAIP1 ceRNA network for the Abeta pathogenic pathway in AD. +transcription factor target 35278407 hsa-mir-106a Glomerulonephritis, IGA At the cut-off >/= 800 copy per 1000 copies of housekeeping gene, urinary miR-106a has 100% sensitivity and 14.8% specificity in detecting IgA nephropathy. Conclusions We identified 6 miRNA targets whose urinary levels are significantly elevated in IgAN, and urinary miR-106a level has an excellent sensitivity for the identification of IgAN. +lncRNA target 35278365 hsa-mir-141 Angelman Syndrome OIP5-AS1 indirectly increased HMGB1 expression in VSMCs by targeting miR +other 35278177 hsa-mir-192 Diabetic Nephropathies In addition, the expression of miR-29a is significantly increased, whereas miR-192 decreased after treatment with KSCs (P < 0.05). +other 35278177 hsa-mir-29a Diabetic Nephropathies In addition, the expression of miR-29a is significantly increased, whereas miR-192 decreased after treatment with KSCs (P < 0.05). +transcription factor target 35278152 hsa-mir-629 Asthma induced 16HBE cells' injury and inflammation by targeting FOXA2. +transcription factor target 35278152 hsa-mir-629 Inflammation induced 16HBE cells' injury and inflammation by targeting FOXA2. +lncRNA target 35278064 hsa-mir-362 Carcinoma, Hepatocellular In conclusion, this study demonstrates that ZC3H13 is a direct target of miR +lncRNA target 35278064 hsa-mir-425 Carcinoma, Hepatocellular In conclusion, this study demonstrates that ZC3H13 is a direct target of miR +transcription factor target 35277920 hsa-mir-27b Equine Infectious Anemia RNA-sequencing analysis indicates that high miR-27b-3p expression levels in IAE may regulate macrophages by targeting macrophage colony-stimulating factor-1 (CSF-1). +circRNA target 35277867 hsa-mir-558 Pneumonia, Mycoplasma Circ-OPHN1 and THBS2 levels were enhanced, while miR-558 level was declined in PE placental tissues. Circ-OPHN1 inhibited trophoblast cell proliferation, migration, and invasion through mediating miR-558/THBS2 axis, providing a novel pathway for PE pathogenesis. +lncRNA target 35277830 hsa-mir-95 Acute Lung Injury In conclusion, MIR3142HG is increased in sepsis-induced ALI, and MIR3142HG could accelerate the progression of sepsis-induced ALI through miR5p/JAK2 axis, providing theoretical evidence for MIR3142HG to be a promising target for the therapeutics of ALI. +genetics_knock down_promote 35277830 hsa-mir-142 Acute Lung Injury Knockdown of MIR3142HG facilitated cell viability but impaired cell apoptosis and inflammatory response via targeting miR +other 35277182 hsa-mir-199a Carcinoma, Hepatocellular CONCLUSIONS: Circ-ZEB1 promoted the expression of PIK3CA by depleting miR-199a-3p, thereby affecting HCC proliferation and apoptosis. +lncRNA target 35276698 hsa-mir-1272 Carcinoma, Renal Cell The current findings demonstrated that circ_0003146 contributed to the malignant progression of ccRCC via inducing SCARB1 upregulation by targeting miR-1272. +genetics_overexpression_promote 35276697 hsa-mir-21 Ovarian Neoplasms Meanwhile, PEG3 overexpression abrogated miR +circRNA target 35276696 hsa-mir-545 Colorectal Neoplasms CircSAMD4A contributed to 5-Fu resistance of CRC cells partly through upregulating PFKFB3 expression by sponging miR3p, providing a possible circRNA-targeted therapy for CRC. +genetics_knock down_promote 35276693 hsa-mir-612 Nasopharyngeal Carcinoma ZFPM2-AS1 knockdown considerably restrained NPC development via targeting the miR-3612/DTL signaling. +lncRNA target 35276351 hsa-mir-200a Venous Thromboembolism Moreover, miR-200a-5p might be a therapeutic target for VTE. +other 35276240 hsa-mir-122 Polycystic Ovary Syndrome 5p in the development of granulosa cells (GCs). +other 35276240 hsa-mir-122 Ovarian Diseases In present study, we found that miR5p was highly expressed in chicken atrophic ovaries. +other 35276183 hsa-mir-142 Myopia We aimed to explore the effect and regulatory mechanism of hsa-miR3p on collagen I in human scleral fibroblasts in high myopia. +other 35275699 hsa-mir-491 Gluteal Muscle Contracture 5p might be a potentially effective biomarker for predicting GMC, providing a novel therapeutic strategy for GMC. +other 35275699 hsa-mir-491 Diabetic Nephropathies 5p might be a potentially effective biomarker for predicting GMC, providing a novel therapeutic strategy for GMC. +circulation_biomarker_diagnosis_ns 35275615 hsa-mir-135b Urinary Bladder Neoplasms Furthermore, the simultaneous analysis of BC-related exosomal miR-133b and miR-135b in clinical serum specimens was achieved and consistent with qRT-PCR, suggesting it is a potential method for the diagnosis of BC and other cancers. +lncRNA target 35275525 hsa-mir-223 Angelman Syndrome 3p inhibited ox-LDL-mediated NLRP3 inflammasome activation via directly targeting NLRP3 and FOXO3 in THP-1 cells, which offered a prospective therapeutic target for AS therapy. +exosome 35275523 hsa-mir-138 Melanoma 5p from exosomes released by human mesenchymal stem cells (HMSCs) on the pathogenesis of melanoma. +lncRNA target 35275522 hsa-mir-224 Carcinoma, Non-Small-Cell Lung Moreover, molecular mechanistic research suggested that miR-224 enhanced NSCLC by directly targeting the tumor suppressor angiopoietin-like protein (ANGPTL). +lncRNA target 35275356 hsa-mir-196 Adenocarcinoma of Lung In conclusion, our findings suggest that MAFG-AS1/miR-3196/SOX12 axis regulates LUAD progression and is a potential therapeutic target for LUAD. +genetics_knock down_suppress 35275355 hsa-mir-483 Glioma 3p expression and SOX3 overexpression reversed the biological effects of LINC00662 knockdown on glioma cells. +genetics_overexpression_suppress 35275273 hsa-mir-518c Endometriosis A rat model of EMs overexpressing miR-518c-3p alone or ZNF608 simultaneously was constructed to detect ectopic endometrial cell apoptosis and cyst volume in rats. +lncRNA target 35274813 hsa-mir-582 Cholangiocarcinoma Finally, we showed that YAP1 was a target of NKILA via miR3p and NKILA functioned partially via YAP1 in CCA. +circRNA target 35274779 hsa-mir-217 Uterine Cervical Neoplasms CONCLUSION: circ_0119412 functioned as an oncogenic driver to promote the malignant development of cervical cancer by targeting the miR-217/AGR2 pathway. +other 35274778 hsa-mir-7974 Femur Head Necrosis CONCLUSIONS: hsa_circ_0058122/miR-7974/IGFBP5 was proposed to be a key regulatory pathway for SONFH. +genetics_knock down_promote 35274735 hsa-mir-19b Carcinoma, Non-Small-Cell Lung Whilst overexpression of miR-19b-3p was demonstrated to promote the proliferation and invasion of NSCLC cells, knockdown of miR-19b-3p showed an opposite inhibitory effect. +lncRNA target 35274504 hsa-mir-92a Acute Lung Injury CONCLUSIONS: miRNA-92a inhibitor could exert an inhibition role on oxidative stress and endothelial dysfunction to improve diabetic ED effectively. +lncRNA target 35274504 hsa-mir-92a Erectile Dysfunction, Diabetic CONCLUSIONS: miRNA-92a inhibitor could exert an inhibition role on oxidative stress and endothelial dysfunction to improve diabetic ED effectively. +lncRNA target 35274504 hsa-mir-92a Diabetes Mellitus, Type 2 CONCLUSIONS: miRNA-92a inhibitor could exert an inhibition role on oxidative stress and endothelial dysfunction to improve diabetic ED effectively. +lncRNA target 35274492 hsa-mir-660 Melanoma The mechanism study showed that circITCH-sponged miR-660 to upregulate TFCP2 and suppress melanoma progression. CONCLUSIONS: The circITCH/miR-660/TFCP2 axis is involved in melanoma progression hence circITCH can be a diagnostic biomarker as well as a target for treating melanoma. +other 35274397 hsa-mir-141 Osteosarcoma In summary, this study suggested that the expression of SNHG10 markedly elevated within OS, and the SNHG10/miR3p/WTAP axis facilitated OS progression. +genetics_overexpression_promote 35274138 hsa-mir-29a Diabetic Cardiomyopathies Compared with control group, the protein expression of Bax, cleaved-caspase3 and Bak1 in DCM and HG groups were significantly upregulated, and the expression of Bcl-2 and Mcl-1 was downregulated, while miR-29a overexpression exerted opposite effect. +transcription factor target 35274048 hsa-mir-29a Breast Neoplasms They were targeted by hsa-miR-29a/c, and the expression levels of hsa-miR-29a/c were associated with a poor prognosis of BCa. +circulation_biomarker_diagnosis_up 35274002 hsa-mir-29b Inflammatory Bowel Diseases Excessive plasma exosomal miR-29b suppresses critical proteins like BDNF in IBD, leading to cardiac impairment. +target gene 35273739 hsa-mir-193a Colorectal Neoplasms Over-expression of miR-193a-3p regulates the apoptosis of colorectal cancer cells by targeting PAK3. +other 35273726 hsa-mir-24 Melanoma HCG18 was found to reverse the effect of miR5p by upregulating CDK16 expression in melanoma cell proliferation, apoptosis, migration and invasion in vitro. +other 35273698 hsa-mir-24 Colonic Neoplasms VPS9D1-AS1, a novel long-non-coding RNA, acts as a tumor promoter by regulating the miR-324-5p/ITGA2 axis in colon adenocarcinoma. +other 35273693 hsa-let-7c Down Syndrome In order to further understand the potential roles of miRNAs in the pathogenesis of AD, we analyzed Down syndrome (DS), a special model of AD, by using a TaqMan microRNA array and found that miRNA let-7c was up-regulated in both DS and AD. +lncRNA target 35273692 hsa-mir-127 Carcinoma, Non-Small-Cell Lung BACKGROUND: This study set out to explore the regulatory relationship between LINC00961/miR-3127 axis and non-small-cell lung carcinoma (NSCLC), so as to provide a new and effective molecular target for targeted therapy of NSCLC. +lncRNA target 35273690 hsa-mir-409 Colonic Neoplasms Our results confirmed that LINC00630 regulates proliferation, glycolysis, and apoptosis mainly through targeting the miR +other 35273684 hsa-mir-1275 Multiple Sclerosis Finally, by analyzing LINC00649-miRCD20, we identified 6 drugs that may represent novel drugs for MS. +circulation_biomarker_diagnosis_up 35273615 hsa-mir-140 Encephalitis, Viral 5p combined with serum C3 would be a promising marker in the differential diagnosis of anti-NMDAR encephalitis with VE. +other 35273591 hsa-mir-423 lung squamous cell carcinoma 5p axes. +genetics_knock down_promote 35272674 hsa-mir-889 Stomach Neoplasms Moreover, GC cells were subjected to ectopic expression and knockdown manipulations of circDYRK1A, miR +genetics_knock down_promote 35272621 hsa-mir-185 Myocardial Reperfusion Injury CONCLUSION: LINC00461 knockdown attenuates myocardial I/R injury via elevating miR +genetics_GWAS 35272550 hsa-mir-140 Vascular Calcification 5p, toll like receptor 4 (TLR4) and vascular calcification-related proteins (alpha-smooth muscle actin, alpha-SMA; Msh Homeobox 2, MSX2; bone morphogenetic protein 2, BMP2; Kruppel-like factor 4, KLF4; Runt-related transcription factor 2, RUNX2) were measured through quantitative real time polymerase chain reaction (qRT-PCR) and western blot. +circulation_biomarker_diagnosis_ns 35272213 hsa-mir-21 Carcinoma, Non-Small-Cell Lung Moreover, the developed method is successfully applied to evaluate the expression level of miRNA-21 in serum of NSCLC patients. +other 35272010 hsa-mir-223 Conjunctivitis, Allergic This study aims to explore the clinical implications of miR-223 in allergic conjunctivitis (AC) and the related factors affecting disease recurrence. These results indicate that miR-223 plays an important role in the pathology of allergic conjunctivitis. +exosome 35271999 hsa-mir-140 Obesity In summary, the current study provides evidence that obese ATM-exosomal miR +exosome 35271999 hsa-mir-140 Heart Injuries In summary, the current study provides evidence that obese ATM-exosomal miR +other 35271943 hsa-mir-101 Silicotuberculosis 3p and then up-regulate the expression of ZEB1, thus promoting the EMT process of alveolar epithelial cells in the process of silicosis-related pulmonary fibrosis EMT. +lncRNA target 35271760 hsa-mir-16 Cholangitis, Sclerosing, Primary Targeting the FGF1 and miR-16 axis may provide therapeutic options in treating cholangiopathies such as PSC. +lncRNA target 35271760 hsa-mir-16 Liver Cirrhosis Targeting the FGF1 and miR-16 axis may provide therapeutic options in treating cholangiopathies such as PSC. +other 35271662 hsa-mir-155 Diabetes Mellitus, Type 2 In addition, according to the TF-gene interactions network and TF-miRNA coregulatory network, part of TF and miRNA may be identified as key regulator in sarcopenia and T2DM at the same time (e.g., CREM and miR-155). +other 35271662 hsa-mir-155 Sarcopenia In addition, according to the TF-gene interactions network and TF-miRNA coregulatory network, part of TF and miRNA may be identified as key regulator in sarcopenia and T2DM at the same time (e.g., CREM and miR-155). +other 35271544 hsa-mir-541 Acute Lung Injury 5p is a key effector in ALI tissue, and that LPS-induced ATII cells act by regulating HMGB1 expression. +genetics_GWAS 35270805 hsa-mir-146a Polycystic Ovary Syndrome This study has characterized the clinical parameters in PCOS patients with comprehensive biochemical profiling compared to healthy controls and further examined the influence of allelic variations for estrogen receptor-alpha (ESR1 PvuII-rs2234693 T>C) and miRNA-146a (rs2910164 C>G) gene polymorphism on the risk of and susceptibility to PCOS. On the contrary, the study found strong association of miRNA-146a (rs2910164 C>G) gene polymorphism with an enhanced risk of PCOS. +transcription factor target 35270010 hsa-mir-124 ACTH-Secreting Pituitary Adenoma 5p and lower expression of their target genes NR3C1 and NR3C2. +transcription factor target 35269968 hsa-mir-661 Glioblastoma This process was inhibited in gliomas due to the low expression of miR-661. +other 35269913 hsa-mir-200c Cytomegalovirus Infections We used miR-200b-3p/miR-200c-3p mimics to counteract the downregulation of these miRNA after acute HCMV infection. Overall, miR-200b-3p and miR-200c-3p-together with p-Ser(536) RelA/p65-can prevent lytic HCMV replication during acute and latent infection. +other 35269913 hsa-mir-200b Cytomegalovirus Infections We used miR-200b-3p/miR-200c-3p mimics to counteract the downregulation of these miRNA after acute HCMV infection. Overall, miR-200b-3p and miR-200c-3p-together with p-Ser(536) RelA/p65-can prevent lytic HCMV replication during acute and latent infection. +lncRNA target 35269749 hsa-mir-124 Pancreatic Carcinoma We also elucidated the mechanism underlying SEMA6C downregulation in pancreatic cancer and demonstrated a novel regulatory role of miR3p in suppressing SEMA6C. +genetics_overexpression_suppress 35269556 hsa-mir-375 Pheochromocytoma We also demonstrated miR-375 overexpression and downregulated (Wnt) signaling and identified the Hippo pathway as a new potentially oncogenic feature of Pheo. +other 35269443 hsa-let-7 Carcinoma, Ovarian Epithelial We confirmed this finding and observed that T308 phosphorylation was yet further reduced in EOC spheroids and that the transition from adherent to spheroid growth is accompanied by significantly increased levels of let-7 miRNAs. +other 35267449 hsa-mir-24-1 Prostatic Neoplasms 1-5p in prostate cancer cases. +other 35267420 hsa-mir-1271 Carcinoma, Renal Cell 5p, and miR-15b-5p levels and three controls. +other 35267420 hsa-mir-15b Carcinoma, Renal Cell 5p, and miR-15b-5p levels and three controls. +other 35267420 hsa-mir-122 Carcinoma, Renal Cell 5p, and miR-15b-5p levels and three controls. +transcription factor target 35267120 hsa-mir-148a Carcinoma, Hepatocellular These data suggest that miR-148a may serve as a therapeutic target for HCC cancer therapy in the future. +other 35266915 hsa-mir-7a Heart Diseases Ppp1r16b networks), which may be a novel mechanism of sevoflurane-induced cardioprotection. +lncRNA target 35266884 hsa-mir-1236 Breast Neoplasms 3p could suppress BC cell proliferation, metastasis and glycolysis, while this effect could be abolished by PFKFB3. +genetics_knock down_promote 35266852 hsa-mir-98 Stomach Neoplasms TTTY15 knockdown inhibited gastric cancer cell proliferation but promoted apoptosis by sponging miR +lncRNA target 35266447 hsa-mir-320d Osteosarcoma Additionally, repressive LINC00641 blocked MCL1 via emulative interaction with miR-320d, thus expediting DDP-sensitivity of OS cells. All in all, it is found that LINC00641 is available to escalate drug resistance of DDP-resistant OS cells via mediation of miR-320d/MCL1 axis. +lncRNA target 35266446 hsa-mir-125a Adenocarcinoma of Lung Overall, our study revealed that LINC01426 might regulate the malignant phenotype of LUAD via the miR-125a-5p/CSNK2A1 axis. +genetics_overexpression_promote 35266369 hsa-mir-19a Colorectal Neoplasms In conclusion, our results revealed that miR-19a overexpression decreases CLCA4 levels to promote CRC oncogenesis, suggesting that miR-19a inhibitors have potential applications for future therapeutic of CRC. +genetics_overexpression_promote 35266110 hsa-mir-221 Glioma Overexpression of SLC25A21-AS1 inhibited glioma progression via miR +genetics_overexpression_promote 35266110 hsa-mir-222 Glioma Overexpression of SLC25A21-AS1 inhibited glioma progression via miR +other 35265764 hsa-mir-191 Malaria, Vivax The expression of miR-191 was 1.405 times higher in patients with malaria compared to that in the controls, although the difference was statistically insignificant. +other 35265629 hsa-mir-137 Colonic Neoplasms The microRNA shared by BCL2A1 and PD-L1, hsa-miR-137, were significantly associated with CCL18, BCL2A1, and PD-L1, and downregulated in low-IC50 group. +genetics_knock down_suppress 35265621 hsa-mir-124 Choroidal Neovascularization Mechanistically, through the lncRNA-RNA binding protein-miRNA interaction analysis involving loss of function and gain-of-function experiments, we found that lncRNA PNKY inhibited the binding of miR124 to PTBP1 and maintained the homeostasis of choroidal vascular function by promoting Bcl-2 like protein 11 (BIM), and its dysfunction led to exacerbation of CNV lesion. Therefore, this study suggests that the lncPNKY/PTBP1-miR-124 axis is involved in regulating the development of CNV, providing a potential therapeutic target for the treatment of CNV. +circulation_biomarker_diagnosis_ns 35265305 hsa-mir-196b Pregnancy, Ectopic qRT-PCR showed that miR-196b expression in peripheral blood of EP patients was lower than that of normal people. +exosome 35265076 hsa-mir-885 Graves Ophthalmopathy Exosome mir +exosome 35265076 hsa-mir-4474 Graves Ophthalmopathy 3p were downregulated in the exosomes of SI patients. +exosome 35265076 hsa-mir-615 Graves Ophthalmopathy 3p were downregulated in the exosomes of SI patients. +lncRNA target 35264957 hsa-mir-18a Carcinoma, Hepatocellular In addition, a rescue experiment found miR-18a-3p mimic partly reversed the suppression of hsa_circ_0098181 on proliferation, invasion, and migration of HCC cell lines. In conclusion, hsa_circ_0098181 can repress the development of HCC through sponging miR-18a-3p and promoting the expression of PPARA in vitro and in vivo, and hsa_circ_0098181 might be a therapeutic target for HCC. +circulation_biomarker_diagnosis_ns 35264879 hsa-mir-96 Carcinoma, Hepatocellular These findings suggested that serum miRNA +circulation_biomarker_diagnosis_ns 35264879 hsa-mir-99a Carcinoma, Hepatocellular These findings suggested that serum miRNA +circulation_biomarker_diagnosis_ns 35264708 hsa-mir-155 Brucellosis Taken together, data from this study indicate that Brucella infection affects miR-155 expression and that human brucellosis patients show decreased serum levels of miR-155. +circulation_biomarker_diagnosis_ns 35264203 hsa-mir-9 Depression 5p expression levels in serum exosomes from MDD patients than healthy control (HC) subjects. +transcription factor target 35264186 hsa-mir-378 Glomerulonephritis, Membranoproliferative CONCLUSION: UcMSC-Evs ameliorate pathological process in MsPGN through the delivery of miR-378, which suppresses PSMD14-mediated TGFBR1 stability and inactivates the TGF-beta1/Smad2/3 signaling pathway to reduce tissue hyperplasia and rMC proliferation. +lncRNA target 35264092 hsa-mir-29a Osteoarthritis CONCLUSION: In conclusion, this work highlights the role of the POU3F3/miR-29a-3p/FOXO3 axis in the OA pathogenesis, suggesting this axis as a potential therapeutic target for OA. +genetics_overexpression_promote 35264071 hsa-mir-515 Thyroid Neoplasms 5p repressed the Smad4 expression level, consequently reversed the inhibiting effect of overexpressed CATIP-AS1 on the proliferation, and migration of THCA cell. +other 35264070 hsa-mir-26b Osteosarcoma In conclusion, Circ_ANKIB1 binds miR-26b-5p and modulates EZH2 to accelerate the chemo-resistance of osteosarcoma. +lncRNA target 35264067 hsa-mir-409 Glioma PDK1 acted as a target gene of miR +lncRNA target 35264065 hsa-mir-129 Thyroid Cancer, Papillary LARP1, a downstream target of miR +other 35264058 hsa-mir-338 Acute Lung Injury Collectively, our study indicates that circ_0001679/miR3p/MAPK1 axis may play an important role in the pathogenesis of acute lung injury (ALI). +other 35263585 hsa-mir-130a Leukemia, Myeloid, Acute, T-Cell Moreover, we report that miR-130a is highly expressed in t(8;21) acute myeloid leukemia (AML), where it is critical for maintaining the oncogenic molecular program mediated by the AML1-ETO complex. +circulation_biomarker_diagnosis_up 35263556 hsa-mir-181a Fractures, Bone The binding between SNHG1/miR-181a-5p/PTEN was detected by dual-luciferase reporter gene assay.Results: Serum SNHG1 and PTEN expression were upregulated and miR-181a-5p expression was downregulated in patients with delayed fracture healing. Finally, elevated SNHG1 was a feasible predictive biomarker in patients with delayed fracture healing.Conclusion: The current study revealed that SNHG1/miR-181a-5p/PTEN axis inhibited osteoblast differentiation and proliferation and promoted apoptosis, thus leading to the inhibition of tibial fracture healing. +lncRNA target 35263556 hsa-mir-181a Tibial Fractures Finally, elevated SNHG1 was a feasible predictive biomarker in patients with delayed fracture healing.Conclusion: The current study revealed that SNHG1/miR-181a-5p/PTEN axis inhibited osteoblast differentiation and proliferation and promoted apoptosis, thus leading to the inhibition of tibial fracture healing. +other 35262985 hsa-mir-139 Mouth Neoplasms 5p and miR-30a-5p panel was confirmed as a potential diagnostic biomarker when distinguishing oral cancer from non-cancerous tissue. +other 35262985 hsa-mir-1 Mouth Neoplasms 5p and miR-30a-5p panel was confirmed as a potential diagnostic biomarker when distinguishing oral cancer from non-cancerous tissue. +lncRNA target 35262876 hsa-mir-559 Ovarian Neoplasms MiR-559 expression was remarkably reduced in OC tissues and cell lines, and miR-559 markedly suppressed the malignant characteristics of OC cells. CCNB1, of which expression is modulated by miR-559, facilitates proliferation, migration, and invasion of OC cells, therefore, working as a potential therapeutic target of OC. +lncRNA target 35262384 hsa-mir-143 Corneal Injuries In addition, either LINC00963 promotion or miR3p inhibition could significantly decrease myofibroblast contractility and collagen I and III secretion, which are the key to contribute to corneal fibrosis. +target gene 35261900 hsa-mir-450b Carcinoma, Non-Small-Cell Lung Circular RNA circTADA2A promotes the proliferation, invasion, and migration of non-small cell lung cancer cells via the miR-450b-3p/HMGN5 signaling pathway. +lncRNA target 35261804 hsa-mir-335 Opitz GBBB Syndrome, X-Linked In addition, SNHG15 suppresses cisplatin-induced apoptosis and ROS accumulation through the miR3p/ZNF32 pathway. +lncRNA target 35261562 hsa-mir-9 Non-alcoholic Fatty Liver Disease 5p in NAFLD-EVs alleviated macrophage inflammation and M1 polarization as evidenced by reduced levels of macrophage inflammatory factors, positive rates of CD86(+) CD11b(+), and levels of macrophage surface markers in vitro. +circulation_biomarker_diagnosis_ns 35261213 hsa-mir-200b Ischemic Attack, Transient CONCLUSION: Serum miR-200b-3p expression was increased in TIA patients with considerable diagnostic value to screen TIA cases from healthy controls. +circulation_biomarker_diagnosis_ns 35261213 hsa-mir-200b Cerebral Infarction CONCLUSION: Serum miR-200b-3p expression was increased in TIA patients with considerable diagnostic value to screen TIA cases from healthy controls. +transcription factor target 35260928 hsa-mir-21 Carcinoma, Squamous Cell PDCD4 axis via (1)O(2) induced by HMME-PDT. +circulation_biomarker_diagnosis_up 35260775 hsa-mir-126 Kidney Failure, Chronic This study showed for the first time that there is a dysregulation of whole blood miR +lncRNA target 35260554 hsa-mir-556 Stomach Neoplasms KCNQ1OT1, microRNA (miR)3p and CLIC1 expression of GC tissues was detected through RT-qPCR. +genetics_knock down_promote 35260183 hsa-mir-189 Glioblastoma mediated GLUT3 inhibition shows an anti-tumorigenic effect and cell death by regulating glucose metabolism in HDAC2 knockdown GBM. +genetics_overexpression_promote 35260141 hsa-mir-765 Colonic Neoplasms The overexpression of USP30-AS1 dramatically suppressed colon cancer cellular processes, which was alleviated by miR-765. +genetics_overexpression_suppress 35260066 hsa-mir-129-2 Esophageal Neoplasms 2-3p repressed EC cell progression while further overexpressing DNMT3B would restore the above inhibitory effect. +lncRNA target 35260044 hsa-mir-545 Carcinoma, Non-Small-Cell Lung FAM83H-AS1 favors non-small cell lung cancer by targeting the miR3p/HS6ST2 axis, supporting the possibility of developing FAM83H-AS1 as a target for NSCLC intervention. +other 35260041 hsa-mir-29b Osteoarthritis RESULTS: MiR-29b-3p level was upregulated in cartilage tissues of OA patients (3.5-fold change, p < 0.001) and IL-1beta stimulated chondrocytes (two fold change, p < 0.001). +circRNA target 35259622 hsa-mir-19a Pneumonia, Mycoplasma Oxidative injury-mediated placental trophoblast dysfunction in PE was through competing endogenous RNA (ceRNA) mechanism of CircFN1-miR-19a/b-3p-ATF2 axes. +circRNA target 35259622 hsa-mir-19b Pneumonia, Mycoplasma Oxidative injury-mediated placental trophoblast dysfunction in PE was through competing endogenous RNA (ceRNA) mechanism of CircFN1-miR-19a/b-3p-ATF2 axes. +transcription factor target 35259612 hsa-mir-134 Hypoxia-Ischemia, Brain CONCLUSION: This study demonstrates that Dex treatment can alleviate HIBD in neonatal rats through restoring NLRX1 expression by suppressing miR +lncRNA target 35259352 hsa-mir-153 Stress Disorders, Post-Traumatic The downregulation of miR-153 could alleviate the PTSD-like behaviors in the rats exposed to SPS, and this effect might be related to the upregulation of sigma-1R and PSD95. The results of this study indicated that miR-153 might alleviate PTSD-like behaviors by regulating cell morphology and reducing cell apoptosis in the hippocampus of rats exposed to SPS by targeting sigma-1R, which might be related to the mTOR signaling pathway. +lncRNA target 35259061 hsa-mir-1 Pre-Eclampsia Collectively, our study demonstrated that lncRNA SNHG5 alleviated the PE phenotype and inhibited trophoblast autophagy by sponging miR5p and promoting SPARC transcription. +transcription factor target 35259053 hsa-mir-103a Syphilis All in all, BBR represses Wnt/beta-catenin pathway activation via modulating the miR-103a-3p/BRD4 axis, thereby mitigating colitis-stimulated pyroptosis and the intestinal mucosal barrier defect. +transcription factor target 35259053 hsa-mir-103a Colitis All in all, BBR represses Wnt/beta-catenin pathway activation via modulating the miR-103a-3p/BRD4 axis, thereby mitigating colitis-stimulated pyroptosis and the intestinal mucosal barrier defect. +genetics_knock down_promote 35259051 hsa-mir-141 Retinoblastoma 3p overexpression increased retinoblastoma growth and angiogenesis, which is partially reversed when SUSD2 is over-expressed both in vivo and in vitro. +lncRNA target 35259044 hsa-mir-16 Endometrial Neoplasms Results indicated hsa-miR-497/16-5p expression were down-regulated, and mechanistic target of rapamycin kinase (mTOR) was up-regulated in EC. In conclusion, hsa_circ_0011324 could sponge hsa-miR-497/16-5p targeted mTOR to participate in EC progress. +lncRNA target 35259044 hsa-mir-497 Endometrial Neoplasms Results indicated hsa-miR-497/16-5p expression were down-regulated, and mechanistic target of rapamycin kinase (mTOR) was up-regulated in EC. In conclusion, hsa_circ_0011324 could sponge hsa-miR-497/16-5p targeted mTOR to participate in EC progress. +lncRNA target 35258413 hsa-mir-186 Colonic Neoplasms 3p/KRT18 axis may be a promising therapeutic target for colon carcinoma.Abbreviations: KRT18: keratin 18; NC: negative control; si: small interfering RNA; inhibitor: miR +genetics_knock down_suppress 35258410 hsa-mir-455 Squamous Cell Carcinoma of Head and Neck 3p or ELF3 knockdown was shown to be capable of reversing the anti-tumor effects of LINC00472 in OSCC. +genetics_overexpression_promote 35258403 hsa-mir-486 Glioblastoma 5p overexpression suppressed cell growth, migration, invasion, epithelial-mesenchymal transition (EMT) and tumorigenesis in GBM cells in vitro and in vivo. +genetics_knock down_promote 35258395 hsa-mir-1301 Carcinoma, Hepatocellular 3p overexpression or METTL3 knockdown could partially counteract hsa_circ_0008583 overexpression-mediated influence on HCC cell behaviors. +genetics_knock down_promote 35258173 hsa-mir-130a Carcinoma, Renal Cell Both miR-130a-3p inhibitor and ESCO2 overexpression could rescue the inhibitory effects of ZFPM2-AS1 knockdown in RCC cells. +other 35257808 hsa-mir-551b Reperfusion Injury, Cerebral Ischemia Taken together, experimental data reveals a direct link between miR-551b-5p and BDNF-mediated signaling cascade in early convalescence of stroke. +lncRNA target 35257356 hsa-mir-21 Premature Birth Overall, the study findings indicate that miR-21 may contribute to the pathogenesis of infection-induced PTB by upregulating the target NF-B and that miR-21 may be a new potential therapeutic target for infection-induced PTB. +other 35257310 hsa-mir-221 Thyroid Neoplasms Our study provided the new insights into the mechanism by which miR3p functions in the development of TC. +exosome 35257299 hsa-mir-5627 Spinal Cord Injuries In conclusion, MSCs-exosomes lncGm36569 inhibited neuronal cell ferroptosis through miR5p/FSP1 axis, thereby attenuating neuronal dysfunction. +other 35257270 hsa-mir-191 Cardiomyopathies "5p/TRAF3 signaling, which might provide some convincing evidences for further understanding the influences of ""lncRNA-miRNA-mRNA"" network in the development of MI." +circulation_biomarker_diagnosis_ns 35257132 hsa-mir-486 Lung Neoplasms The sensor can achieve single, dual, and triple biomarker detections of three lung cancer-related nucleic acid and protein biomarkers, i.e., miRNA-21, miRNA-486 and carcinoembryonic antigen (CEA) in human serum. +exosome 35256956 hsa-mir-29 Lung Neoplasms Indeed, our clinical lung tumor data shows that miR-29a-3p expression negatively correlates with collagen I expression in lung tumors and positively correlates with patients' outcomes. In this study, we found that the chemotherapy drug cisplatin facilitated miR-29a-3p accumulation in the exosomes of lung tumor cells, and this type of exosomes exhibited a specific lung-targeting effect and promising collagen down-regulation. +exosome 35256956 hsa-mir-29a Lung Neoplasms Indeed, our clinical lung tumor data shows that miR-29a-3p expression negatively correlates with collagen I expression in lung tumors and positively correlates with patients' outcomes. In this study, we found that the chemotherapy drug cisplatin facilitated miR-29a-3p accumulation in the exosomes of lung tumor cells, and this type of exosomes exhibited a specific lung-targeting effect and promising collagen down-regulation. +other 35256892 hsa-mir-551b Pancreatitis, Acute Hemorrhagic OBJECTIVE: This study focused on investigating the effects of microRNA551b-5p (miR-551b-5p) on severe acute pancreatitis. +transcription factor target 35256888 hsa-mir-136 Epilepsy, Temporal Lobe CONCLUSION: miR-136 could exert its neuroprotective influence on temporal lobe epilepsy rats by inhibiting the Wnt/beta-catenin signaling pathway. +lncRNA target 35256884 hsa-mir-1301 Pancreatic Carcinoma 3p suppressed the proliferation and migration abilities of PC cells. +lncRNA target 35256585 hsa-mir-185a Osteoarthritis Interestingly, we found that the anabolic activities of melatonin involved the MT(1) receptor, which upregulated microRNA-185a through the PI3K/Akt and ERK signaling pathways in OA synovial fibroblasts. +lncRNA target 35256570 hsa-mir-5194 Melanoma Finally, LINC01063 was tested to facilitate the malignant behaviors of melanoma cells via targeting miR-5194/SOX12. Our study revealed the oncogenic effects of LINC01063 on melanoma cell/tumor growth and its molecular mechanism involving miR-5194/SOX12, which might support LINC01063 to be the potential prognostic or therapeutic biomarker against melanoma. +transcription factor target 35255935 hsa-mir-875 Stomach Neoplasms 5p inhibited the proliferation, migration and invasion of GC cells in vitro and inhibited tumorigenesis in vivo. +lncRNA target 35255921 hsa-mir-423 Esophageal Squamous Cell Carcinoma 5p/PAK6 axis may serve as promising diagnostic and prognostic biomarkers and therapeutic targets for ESCC. +therapeutic target 35255904 hsa-mir-497 Breast Neoplasms DNA methyltransferase 1 inhibits microRNA-497 and elevates GPRC5A expression to promote chemotherapy resistance and metastasis in breast cancer. +circulation_biomarker_diagnosis_up 35255856 hsa-mir-204 Hypertension miR-204 level in the serum was positively correlated with TNF-alpha, IL-6, and hs-CRP concentrations in HDCP patients. +other 35255782 hsa-mir-21 Carcinoma, Renal Cell CONCLUSIONS: This meta-analysis suggests that miR-210, miR-378, miR-1233, and miR-21 have high accuracy in diagnosing RCC. +other 35255782 hsa-mir-1233 Carcinoma, Renal Cell CONCLUSIONS: This meta-analysis suggests that miR-210, miR-378, miR-1233, and miR-21 have high accuracy in diagnosing RCC. +other 35255782 hsa-mir-378 Carcinoma, Renal Cell CONCLUSIONS: This meta-analysis suggests that miR-210, miR-378, miR-1233, and miR-21 have high accuracy in diagnosing RCC. +other 35255782 hsa-mir-210 Carcinoma, Renal Cell CONCLUSIONS: This meta-analysis suggests that miR-210, miR-378, miR-1233, and miR-21 have high accuracy in diagnosing RCC. +tissue_expression_down 35255737 hsa-mir-379 Osteoarthritis Safranin O-fast green staining, immunohistochemistry, and WB were performed to observe the effect of miR +other 35255686 hsa-mir-153 Myocardial Infarction 3p by nHA-CLPs. +transcription factor target 35254877 hsa-mir-34a Non-alcoholic Fatty Liver Disease In conclusion, RSV prevents HFD-induced insulin resistance and hepatic steatosis by suppressing miR-34a-induced activation of SIRT1. +transcription factor target 35254825 hsa-mir-383 Dengue Herein, we discovered that miR5p targets certain lipid and cholesterol biosynthetic pathways and restricts Dengue virus (DENV) infection in hepatic cells. +lncRNA target 35254597 hsa-mir-139 Carcinoma, Hepatocellular 5p/ENAH is hopefully to be the possible target for HCC patients. +transcription factor target 35254116 hsa-mir-518a-2 Lung Adenocarcinoma We further explored the FHIT-associated kinase (PRKCQ, AURKB and ATM in LUAD as well as PLK3 in LUSC) and FHIT-associated miRNA targets (MIR-188, MIR-323, and MIR-518A-2 in LUAD). +transcription factor target 35254116 hsa-mir-188 Lung Adenocarcinoma We further explored the FHIT-associated kinase (PRKCQ, AURKB and ATM in LUAD as well as PLK3 in LUSC) and FHIT-associated miRNA targets (MIR-188, MIR-323, and MIR-518A-2 in LUAD). +transcription factor target 35254116 hsa-mir-23 Lung Adenocarcinoma We further explored the FHIT-associated kinase (PRKCQ, AURKB and ATM in LUAD as well as PLK3 in LUSC) and FHIT-associated miRNA targets (MIR-188, MIR-323, and MIR-518A-2 in LUAD). +lncRNA target 35253975 hsa-mir-155 Retinoblastoma The data in this study suggest that MIR17HG exerts oncogenic effects in RB via the miR +other 35253734 hsa-mir-1 Colorectal Neoplasms MiR5p and RAB27B could also predict the overall survival of MSS CRCs. +lncRNA target 35253605 hsa-mir-21 Pancreatic Carcinoma Curcumol inhibited growth of xenograft-tumors and the biological activities of pancreatic cancer cells by regulating the miR +other 35253371 hsa-mir-29 Intestinal Diseases CONCLUSIONS: We reveal that M-sEVs and miR-29 can accelerate intestinal stem cell-mediated epithelial regeneration and repair epithelial damage. +other 35253371 hsa-mir-29a Intestinal Diseases CONCLUSIONS: We reveal that M-sEVs and miR-29 can accelerate intestinal stem cell-mediated epithelial regeneration and repair epithelial damage. +other 35253153 hsa-mir-199a Spinal Cord Injuries CONCLUSION: LncRNA MALAT1 promotes neuronal apoptosis during SCI by regulating the miR-199a-5p/PRDM5 axis. +other 35252868 hsa-mir-486-1 Tongue Neoplasms We validate the association of Fusobacterium with the inflammatory markers IL1B, IL6 and IL8, miRNAs hsa-mir-451a, hsa-mir-675 and hsa-mir1, and MMP10 in the tongue tumor samples. +other 35252868 hsa-mir-451a Tongue Neoplasms We validate the association of Fusobacterium with the inflammatory markers IL1B, IL6 and IL8, miRNAs hsa-mir-451a, hsa-mir-675 and hsa-mir1, and MMP10 in the tongue tumor samples. +other 35252868 hsa-mir-675 Tongue Neoplasms We validate the association of Fusobacterium with the inflammatory markers IL1B, IL6 and IL8, miRNAs hsa-mir-451a, hsa-mir-675 and hsa-mir1, and MMP10 in the tongue tumor samples. +circRNA target 35252543 hsa-mir-153 Hyalinosis, Systemic Ultimately, we showed that circRNA-0100 promoted the differentiation of SHF-SCs into hair lineage, which might be achieved via sequestering miR +other 35252169 hsa-mir-762 Stomach Neoplasms Circular RNA circ0007360 Attenuates Gastric Cancer Progression by Altering the miR-762/IRF7 Axis. +circRNA target 35252056 hsa-mir-128 Carcinoma, Hepatocellular 3p/c-Met axis may be potential therapeutic targets for circumventing lenvatinib resistance in HCC and warrant further investigation. +exosome 35251967 hsa-mir-125a Nasopharyngeal Carcinoma Overall, the current study shows that MSCs can be utilized to generate exosomes with high miR-125a level, which could be therapeutic nanoparticles targeting VM formation in nasopharyngeal carcinoma and used as a complement to anti-angiogenic therapy in the future. +lncRNA target 35251919 hsa-mir-7 Lung Neoplasms Our study not only delineates how acidification directly affects tumorigenesis, but also suggests miR-7 is a novel reliable biomarker for acidic TME and a novel therapeutic target for non-small cell lung cancer (NSCLC) treatment. +circulation_biomarker_diagnosis_ns 35251580 hsa-mir-122 Hepatitis B In HBV sufferers, the serum miR-122 expression level is related to liver disease progression, hence making it an underlying molecular biomarker for predicting the development of CHB. +genetics_overexpression_suppress 35251568 hsa-mir-186 Breast Neoplasms Overexpression of CXCL13 can significantly neutralize the inhibitory effects of miRNA +other 35251503 hsa-mir-21 Hip Fractures 5p and miR-125b-5p were down-regulated. +other 35251503 hsa-mir-122 Hip Fractures 5p and miR-125b-5p were down-regulated. +other 35251503 hsa-mir-21 Osteoporosis 5p and miR-125b-5p were down-regulated. +other 35251503 hsa-mir-125b Osteoporosis 5p and miR-125b-5p were down-regulated. +other 35251503 hsa-mir-122 Osteoporosis 5p and miR-125b-5p were down-regulated. +other 35251503 hsa-mir-140 Hip Fractures 5p and miR-125b-5p were down-regulated. +other 35251503 hsa-mir-140 Osteoporosis 5p and miR-125b-5p were down-regulated. +other 35251503 hsa-mir-125b Hip Fractures 5p and miR-125b-5p were down-regulated. +lncRNA target 35251377 hsa-mir-1 Nasopharyngeal Neoplasms miR-1 has the potential to be a therapeutic target for NPC. +target gene 35251354 hsa-mir-148a Carcinoma, Non-Small-Cell Lung miR-148a promotes cell sensitivity through downregulating SOS2 in radiation-resistant non-small cell lung cancer cells. +genetics_overexpression_suppress 35251300 hsa-mir-498 Carcinoma, Hepatocellular miR-498 was overexpressed in hepatoma cells, and then, flow cytometry was used to analyze the cell apoptosis rate. +other 35251139 hsa-mir-181c Breast Neoplasms We then constructed a ceRNA network, which identified an lncRNA LINC00665/miR-181c-5p/BCL2 regulatory axis for BRCA. We also constructed a ceRNA network and identified an lncRNA LINC00665/miR-181c-5p/BCL2 regulatory axis for BRCA. +other 35250545 hsa-mir-155 Cognitive Dysfunction Some of the associated genes and miRNAs were shown to interact within the signaling pathways of APP (Amyloid Precursor Protein), ACE2 (Angiotensin Converting Enzyme 2), miR-155 and PPARG (Peroxisome Proliferator Activated Receptor Gamma), which are known to contribute to neuroinflammation and neurodegeneration. +other 35250545 hsa-mir-155 Alzheimer Disease Some of the associated genes and miRNAs were shown to interact within the signaling pathways of APP (Amyloid Precursor Protein), ACE2 (Angiotensin Converting Enzyme 2), miR-155 and PPARG (Peroxisome Proliferator Activated Receptor Gamma), which are known to contribute to neuroinflammation and neurodegeneration. +lncRNA target 35250291 hsa-mir-126 Pulmonary Disease, Chronic Obstructive This study aimed to explore the potential role of endothelial microparticles (EMPs) derived from primary pulmonary microvascular endothelial cells in regulating lung inflammation of chronic obstructive pulmonary disease (COPD) through transferring microRNA-126 (miR-126). CONCLUSION: The present study reveals that EMPs are capable of alleviating lung inflammation and transferring miR-126 can magnify the anti-inflammatory effect of EMPs, which may provide a novel therapeutic alternative for COPD. +lncRNA target 35250291 hsa-mir-126 Pneumonia This study aimed to explore the potential role of endothelial microparticles (EMPs) derived from primary pulmonary microvascular endothelial cells in regulating lung inflammation of chronic obstructive pulmonary disease (COPD) through transferring microRNA-126 (miR-126). CONCLUSION: The present study reveals that EMPs are capable of alleviating lung inflammation and transferring miR-126 can magnify the anti-inflammatory effect of EMPs, which may provide a novel therapeutic alternative for COPD. +circulation_biomarker_diagnosis_ns 35250259 hsa-mir-221 Concussion, Sports-Related CONCLUSION: Circulating levels of miR-27a-3p and miR +circulation_biomarker_diagnosis_ns 35250259 hsa-mir-27a Concussion, Sports-Related CONCLUSION: Circulating levels of miR-27a-3p and miR +lncRNA target 35249882 hsa-mir-132 Atherosclerosis CONCLUSION: MiR-132 promotes atherosclerosis by inducing mitochondrial oxidative stress-mediated ferroptosis, which may serve as a promising therapeutic target for AS. +other 35249869 hsa-mir-221 Carcinoma, Hepatocellular CONCLUSION: Fatty acid metabolism might be one of the most crucial pathways that mediate the effect of the oncomiRNAs in HCC, and the hsa-miR5p/GCDH axis is an important molecular mechanism for HCC progression. +genetics_overexpression_promote 35249453 hsa-mir-193b Reperfusion Injury, Cerebral Ischemia Overexpression of SIAH1 partially reversed the protection of miR-193b-3p overexpression against cerebral I/R injury. Overall, overexpression of miR-193b-3p targeted SIAH1 to inhibit the activation of the JNK pathway and protect rats against cerebral I/R injury. +target gene 35249109 hsa-mir-27b Stomach Neoplasms Long intergenic non-protein coding RNA 467 inhibition elevates microRNA-27b-3p to repress malignant behaviors of gastric cancer cells via reducing STAT3. +genetics_knock down_promote 35249038 hsa-mir-384 Carcinoma, Renal Cell Furthermore, a series of rescue experiments showed that miR-384 inhibition reversed the anticancer effects of circ_0037866 knockdown on RCC cells; besides that, miR-384 restoration suppressed RCC cell growth and mobility, which were attenuated by CBX5 overexpression. CONCLUSION: Circ_0037866 knockdown restrains the tumorigenesis of RCC by miR-384/CBX5, revealing a promising molecular target for RCC therapy. +circRNA target 35248826 hsa-mir-326 Cholangiocarcinoma Functionally, circ_0000591 induced the proliferation, migration and invasion of CCA cells through sponging miR-326. In conclusion, this study revealed a novel regulatory mechanism that circ_0000591 contributed to the progression of CCA via miR-326/TLR4/MyD88/IL6 axis. +other 35248795 hsa-mir-18a hereditary diffuse gastric cancer On analyzing the gastric cancer miRNA expression data, FS-DANI identified two miRNAs (hsa-miR-18a* and hsa-miR-381), whose AUCs for distinguishing gastric cancer samples and normal samples are 0.959 and 0.879 in the discovery set and an independent validation set, respectively. +other 35248795 hsa-mir-381 hereditary diffuse gastric cancer On analyzing the gastric cancer miRNA expression data, FS-DANI identified two miRNAs (hsa-miR-18a* and hsa-miR-381), whose AUCs for distinguishing gastric cancer samples and normal samples are 0.959 and 0.879 in the discovery set and an independent validation set, respectively. +other 35248692 hsa-mir-6506 Pancreatic Carcinoma Degree centrality, betweenness centrality and closeness centrality of nodes in the ceRNA network showed that hsa-mir-570, hsa-mir-944, hsa-mir-6506, hsa-mir-3136, MMP16, PLGLB2, HPGD, FUT1, MFSD2A, SULT1E1, SLC13A5, ZNF488, F2RL2, TNFRSF8, TNFSF11, FHDC1, ISLR2 and THSD7B are hub nodes, which are key RNAs closely determining the OS of pancreatic cancer patients. +other 35248692 hsa-mir-944 Pancreatic Carcinoma Degree centrality, betweenness centrality and closeness centrality of nodes in the ceRNA network showed that hsa-mir-570, hsa-mir-944, hsa-mir-6506, hsa-mir-3136, MMP16, PLGLB2, HPGD, FUT1, MFSD2A, SULT1E1, SLC13A5, ZNF488, F2RL2, TNFRSF8, TNFSF11, FHDC1, ISLR2 and THSD7B are hub nodes, which are key RNAs closely determining the OS of pancreatic cancer patients. +other 35248692 hsa-mir-136 Pancreatic Carcinoma Degree centrality, betweenness centrality and closeness centrality of nodes in the ceRNA network showed that hsa-mir-570, hsa-mir-944, hsa-mir-6506, hsa-mir-3136, MMP16, PLGLB2, HPGD, FUT1, MFSD2A, SULT1E1, SLC13A5, ZNF488, F2RL2, TNFRSF8, TNFSF11, FHDC1, ISLR2 and THSD7B are hub nodes, which are key RNAs closely determining the OS of pancreatic cancer patients. +other 35248692 hsa-mir-570 Pancreatic Carcinoma Degree centrality, betweenness centrality and closeness centrality of nodes in the ceRNA network showed that hsa-mir-570, hsa-mir-944, hsa-mir-6506, hsa-mir-3136, MMP16, PLGLB2, HPGD, FUT1, MFSD2A, SULT1E1, SLC13A5, ZNF488, F2RL2, TNFRSF8, TNFSF11, FHDC1, ISLR2 and THSD7B are hub nodes, which are key RNAs closely determining the OS of pancreatic cancer patients. +lncRNA target 35248684 hsa-mir-140 Cognition Disorders 5p inhibits neurogenesis and neuroplasticity via downregulation of Prox1 and aggravates VCI. +lncRNA target 35248684 hsa-mir-140 Cognitive Impairment, Vascular 5p inhibits neurogenesis and neuroplasticity via downregulation of Prox1 and aggravates VCI. +exosome 35248611 hsa-mir-181a Hair Diseases The exosomal miR-181a-5p might, therefore, act as the novel biomarker and therapeutic target for treating hair-related diseases and wool production in mammals. +exosome 35248611 hsa-mir-181a Heart Failure This study identified a high expression of miR-181a-5p in the low-passage DPC-Exos (exosomes derived from dermal papilla cell), revealing the transportation patterns of the DPC-Exos-derived miR-181a-5p entering the HFSC (hair follicle stem cell). +other 35248525 hsa-mir-29a Stomach Neoplasms The gastric cancer (GC) cell line MKN45 was utilized to verify the regulation of KDM5B using the transcription factor (TF) Yin Yang 1 (YY1) and miR-29a-3p. +genetics_GWAS 35248404 hsa-mir-148a Squamous Cell Carcinoma of Head and Neck 14 base pair Insertion/Deletion polymorphism (rs371194629) and 3142 G/C SNP (rs1063320) of 3'UTR of HLA-G were investigated in conjunction with miR-148A, miR-152 and HLA-G expression in SAB (Spontaneous abortion) history placenta and HNSCC tumor in a hospital-based case control study. +genetics_GWAS 35248404 hsa-mir-152 Squamous Cell Carcinoma of Head and Neck 14 base pair Insertion/Deletion polymorphism (rs371194629) and 3142 G/C SNP (rs1063320) of 3'UTR of HLA-G were investigated in conjunction with miR-148A, miR-152 and HLA-G expression in SAB (Spontaneous abortion) history placenta and HNSCC tumor in a hospital-based case control study. +genetics_overexpression_promote 35248107 hsa-mir-20b Retinoblastoma miR-20b-5p downregulation or RRM2 overexpression facilitated RB cell-cycle and proliferation, suppressed apoptosis, and reversed the protective effect of sh-HOTAIR on RB. +lncRNA target 35247910 hsa-mir-183 Breast Neoplasms Here, we report for the first time the aberrant expression of the putative metastasis suppressing gene SIN3A in human breast cancers and propose a mechanism of SIN3A suppression by miR-183. +other 35247197 hsa-mir-132 Leukemia, Myeloid, Acute ROC analysis confirmed the ability of miR-30a, miR-101, miR-132, miR-129, miR-124, and miR-143 to discriminate both ALL and AML patients with an area under the ROC curve of >/= 0.80 (P < 0.001) and high accuracy. +other 35247197 hsa-mir-129 Leukemia, Myeloid, Acute ROC analysis confirmed the ability of miR-30a, miR-101, miR-132, miR-129, miR-124, and miR-143 to discriminate both ALL and AML patients with an area under the ROC curve of >/= 0.80 (P < 0.001) and high accuracy. +other 35247197 hsa-mir-101 Leukemia, Myeloid, Acute ROC analysis confirmed the ability of miR-30a, miR-101, miR-132, miR-129, miR-124, and miR-143 to discriminate both ALL and AML patients with an area under the ROC curve of >/= 0.80 (P < 0.001) and high accuracy. +other 35247197 hsa-mir-124 Leukemia, Myeloid, Acute ROC analysis confirmed the ability of miR-30a, miR-101, miR-132, miR-129, miR-124, and miR-143 to discriminate both ALL and AML patients with an area under the ROC curve of >/= 0.80 (P < 0.001) and high accuracy. +other 35247197 hsa-mir-143 Leukemia, Myeloid, Acute ROC analysis confirmed the ability of miR-30a, miR-101, miR-132, miR-129, miR-124, and miR-143 to discriminate both ALL and AML patients with an area under the ROC curve of >/= 0.80 (P < 0.001) and high accuracy. +genetics_overexpression_promote 35247196 hsa-mir-520a Carcinoma, Non-Small-Cell Lung CONCLUSION: Overexpression of miR-520a-3p can target and downregulate the expression of AKT1 to inhibit the invasion and metastasis of NSCLC via suppressing the activation of NF-kappaB signaling pathway. +genetics_knock down_promote 35246517 hsa-mir-335 Adenocarcinoma of Lung Furthermore, the knockdown of LINC00518 exhibited a synergistic effect with VS6063, an inhibitor of FAK protein, in the suppression of LUAD indicating that miR +circRNA target 35246505 hsa-mir-7682 Pulmonary Fibrosis In conclusion, we for the first time demonstrated that circRNA_37492 attenuated renal fibrosis via targeting miR3p/Fgb axis, and the homologous hsa_circRNA_0012138 was speculated as a possible ceRNA to regulate multiple gene expressions and involve in human renal fibrosis, suggesting that circRNA_37492/hsa_circ_0012138 may serve as potent therapy target for obstructive renal fibrosis disease. +circulation_biomarker_diagnosis_down 35246384 hsa-mir-150 Dengue demonstrated that human microRNA hsa-miR5p is acquired by mosquitoes during blood meals and protects the Dengue virus by downregulation of chymotrypsin AaCT-1 mRNA. +lncRNA target 35246224 hsa-mir-4324 Ovarian Neoplasms CONCLUSION: Our study found that miR-4324 inhibited FEN1 expression, suppressed cell growth, and increased apoptosis in ovarian cancer cells. +genetics_GWAS 35246121 hsa-mir-21 Hyperglycemia CONCLUSIONS: Our findings demonstrated that HI influenced the epigenetic changes related to miR-21 axis, and sustain the concept of reversibility from dysglycemia. +other 35246121 hsa-mir-21 Albuminuria RESULTS: After HI, we observed a significant reduction of miR-21/ROS/HNE axis in dysglycemic subjects, concomitantly with ameliorating of metabolic parameters, including insulin resistance, BMI, microalbuminuria, reactive hyperemia index and skin fluorescence. +other 35246121 hsa-mir-21 Hyperemia RESULTS: After HI, we observed a significant reduction of miR-21/ROS/HNE axis in dysglycemic subjects, concomitantly with ameliorating of metabolic parameters, including insulin resistance, BMI, microalbuminuria, reactive hyperemia index and skin fluorescence. +lncRNA target 35246069 hsa-mir-543 Diabetic Nephropathies CONCLUSIONS: Our study indicate that miR-543 mediates high-glucose induced DN via targeting TSPAN8. +genetics_knock down_promote 35246019 hsa-mir-142 Cicatrix, Hypertrophic In conclusion, circHECTD1 knockdown interrupts TGF-beta/Smad signaling through miR3p/HMGB1 and suppresses scar fibrosis. +exosome 35246006 hsa-mir-5189 Angelman Syndrome In conclusion, BMSCs-derived exosomes suppress miR3p to facilitate the apoptosis of FLSs via the BATF2/JAK2/STAT3 signaling pathway, which facilitates the understanding of the therapeutic effect of BMSCs on AS and the underlying molecular mechanism. +exosome 35246006 hsa-mir-5189 Freeman-Sheldon syndrome In conclusion, BMSCs-derived exosomes suppress miR +other 35245871 hsa-mir-144 Neurodegenerative Diseases Therefore, TCS acts on GPER to activate the downstream PKC/MAPK signaling pathway, further up-regulating miR-144 expression and causing abnormal modulation of these nerve-related genes to trigger neurodevelopmental toxicity. +transcription factor target 35245628 hsa-mir-150 Cardiac Dysfunction CONCLUSION: Collectively, LSZ protects Ang II-induced cardiac dysfunction and remodeling via upregulation of miR5p to target MMP14. +other 35244999 hsa-mir-659 Prostatic Hyperplasia CONCLUSIONS: The expression ratio of urinary miR-H9 to miR-3659 could be a relevant non-invasive biomarker for PCa diagnosis, particularly for patients within the PSA gray zone. +other 35244999 hsa-mir-659 Prostatic Neoplasms CONCLUSIONS: The expression ratio of urinary miR-H9 to miR-3659 could be a relevant non-invasive biomarker for PCa diagnosis, particularly for patients within the PSA gray zone. +genetics_GWAS 35244769 hsa-mir-1258 Carcinoma, Hepatocellular Next, we identified transcription factor 7 like 2 (TCF7L2 or TCF4) as a target of miR-1258 and found that Kindlin-2 upregulated TCF4 expression by epigenetically suppressing miR-1258 in HCC. +other 35244768 hsa-mir-345 Colonic Neoplasms "RESULTS: Six miRNAs (miR-200a, miR-200b, miR-200c, miR-203, miR-210, miR-345) were upregulated in ""top-of-the-crypt"" cells and positively correlated in expression among colon carcinomas." +other 35244768 hsa-mir-200c Colonic Neoplasms "RESULTS: Six miRNAs (miR-200a, miR-200b, miR-200c, miR-203, miR-210, miR-345) were upregulated in ""top-of-the-crypt"" cells and positively correlated in expression among colon carcinomas." +other 35244768 hsa-mir-203 Colonic Neoplasms "RESULTS: Six miRNAs (miR-200a, miR-200b, miR-200c, miR-203, miR-210, miR-345) were upregulated in ""top-of-the-crypt"" cells and positively correlated in expression among colon carcinomas." +other 35244768 hsa-mir-200b Colonic Neoplasms "RESULTS: Six miRNAs (miR-200a, miR-200b, miR-200c, miR-203, miR-210, miR-345) were upregulated in ""top-of-the-crypt"" cells and positively correlated in expression among colon carcinomas." +other 35244768 hsa-mir-200a Colonic Neoplasms "RESULTS: Six miRNAs (miR-200a, miR-200b, miR-200c, miR-203, miR-210, miR-345) were upregulated in ""top-of-the-crypt"" cells and positively correlated in expression among colon carcinomas." +other 35244768 hsa-mir-210 Colonic Neoplasms "RESULTS: Six miRNAs (miR-200a, miR-200b, miR-200c, miR-203, miR-210, miR-345) were upregulated in ""top-of-the-crypt"" cells and positively correlated in expression among colon carcinomas." +circulation_biomarker_diagnosis_up 35244512 hsa-mir-509 Pulmonary Arterial Hypertension 5p in serum samples of patients with PAH as well as hypoxia-induced PASMCs was significantly down-regulated, whereas DNMT1 was markedly up-regulated. +genetics_overexpression_promote 35244469 hsa-mir-19b Carcinoma, Non-Small-Cell Lung Overexpression of LINC00961 inhibited cell viability, invasion, and induced apoptosis in NSCLC, potentially via suppressing the expression of miR-19a-3p/miR-19b-3p/miR-125b-5p by targeting PI3K-AKT/MAPK/mTOR signaling pathways, which might provide the potential biomarker for NSCLC diagnosis and therapies. +genetics_overexpression_promote 35244469 hsa-mir-125b Carcinoma, Non-Small-Cell Lung Overexpression of LINC00961 inhibited cell viability, invasion, and induced apoptosis in NSCLC, potentially via suppressing the expression of miR-19a-3p/miR-19b-3p/miR-125b-5p by targeting PI3K-AKT/MAPK/mTOR signaling pathways, which might provide the potential biomarker for NSCLC diagnosis and therapies. +genetics_overexpression_promote 35244469 hsa-mir-19a Carcinoma, Non-Small-Cell Lung Overexpression of LINC00961 inhibited cell viability, invasion, and induced apoptosis in NSCLC, potentially via suppressing the expression of miR-19a-3p/miR-19b-3p/miR-125b-5p by targeting PI3K-AKT/MAPK/mTOR signaling pathways, which might provide the potential biomarker for NSCLC diagnosis and therapies. +genetics_GWAS 35244224 hsa-mir-159 Dehydration Therefore, our results uncover a new role for the miR159-MYB33-ABI5 module in the regulation of drought response and seed germination in plants. +circulation_biomarker_diagnosis_up 35244069 hsa-mir-28 Atrial Fibrillation 3p levels in plasma/atrial tissue and patients with AF. +genetics_overexpression_suppress 35243940 hsa-mir-498 Melanoma The overexpression of UBE2T reversed the inhibitory effects of miR-498 on the progression of malignant melanoma cells. +other 35243101 hsa-mir-1269a Carcinoma, Hepatocellular Interestingly, four miRNAs divided into two groups as miR5p/miR-1269a and miR-199a/miR-422a were the most promising for diagnosis of HCC patients from healthy controls, with AUC values of 0.902 and 0.892, respectively. +other 35243101 hsa-mir-199a Carcinoma, Hepatocellular Interestingly, four miRNAs divided into two groups as miR5p/miR-1269a and miR-199a/miR-422a were the most promising for diagnosis of HCC patients from healthy controls, with AUC values of 0.902 and 0.892, respectively. +other 35243101 hsa-mir-182 Carcinoma, Hepatocellular Interestingly, four miRNAs divided into two groups as miR5p/miR-1269a and miR-199a/miR-422a were the most promising for diagnosis of HCC patients from healthy controls, with AUC values of 0.902 and 0.892, respectively. +other 35243101 hsa-mir-422a Carcinoma, Hepatocellular Interestingly, four miRNAs divided into two groups as miR5p/miR-1269a and miR-199a/miR-422a were the most promising for diagnosis of HCC patients from healthy controls, with AUC values of 0.902 and 0.892, respectively. +genetics_overexpression_promote 35242856 hsa-mir-6838 Osteosarcoma Overexpression of circRASSF2 not only promoted the malignant biological behavior of OS cells, but also blocked the anticancer effects of miR +genetics_knock down_promote 35242851 hsa-mir-429 Spinal Cord Injuries Both the mean of adding exosomes extracted from SCI-patients' plasma and knockdown of miR-429 in the culture of SH-SY5Y cells promoted their apoptosis. +other 35242280 hsa-mir-22 Pain, Inflammatory Mtf1 signaling axis in the dorsal horn plays a critical role in the induction and maintenance of inflammatory pain. +lncRNA target 35242202 hsa-mir-195 Carcinoma, Endometrioid CONCLUSIONS: Our research shows the function of sevoflurane in inhibiting the development of endometrial tumors via miRNA +other 35242200 hsa-mir-130b Carcinoma, Hepatocellular Moreover, lncRNA MIR17HG/hsa-miRNA-130b-3p/CASP8 regulatory axis in LIHC was also detected. +other 35242200 hsa-mir-17 Carcinoma, Hepatocellular Moreover, lncRNA MIR17HG/hsa-miRNA-130b-3p/CASP8 regulatory axis in LIHC was also detected. +genetics_overexpression_promote 35242164 hsa-mir-21 Alopecia Conclusion: These results reveal that overexpression of AC010789.1 suppresses AGA progression via downregulation of hsa-miR5p and TGF-beta1 and promotion of the Wnt/beta-catenin signaling pathway, highlighting a potentially promising strategy for AGA treatment. +circulation_biomarker_diagnosis_down 35242102 hsa-mir-29b Subarachnoid Hemorrhage CONCLUSION: We demonstrate that specific miRNAs in plasma, including miR-23b-3p, miR +circulation_biomarker_diagnosis_down 35242102 hsa-mir-142 Subarachnoid Hemorrhage CONCLUSION: We demonstrate that specific miRNAs in plasma, including miR-23b-3p, miR +circulation_biomarker_diagnosis_down 35242102 hsa-mir-20b Subarachnoid Hemorrhage CONCLUSION: We demonstrate that specific miRNAs in plasma, including miR-23b-3p, miR +circulation_biomarker_diagnosis_down 35242102 hsa-mir-590 Subarachnoid Hemorrhage CONCLUSION: We demonstrate that specific miRNAs in plasma, including miR-23b-3p, miR +circulation_biomarker_diagnosis_down 35242102 hsa-mir-23b Subarachnoid Hemorrhage CONCLUSION: We demonstrate that specific miRNAs in plasma, including miR-23b-3p, miR +lncRNA target 35241735 hsa-mir-96 Carcinoma, Renal Cell These results highlight the direct suppression of PTEN by miR +genetics_overexpression_suppress 35241728 hsa-mir-146a Respiratory Syncytial Virus Infections Overexpression of miR-146a targeted down-regulation of TRAF-6 expression and JNK/ERK/MAPK/NF-kappaB pathway induced by RSV infection, reduced the production of inflammatory cytokines IL-1beta, IL-6 and TNF-alpha, and alleviate lung injury in young rats. +genetics_overexpression_suppress 35241728 hsa-mir-146a Lung Injury Overexpression of miR-146a targeted down-regulation of TRAF-6 expression and JNK/ERK/MAPK/NF-kappaB pathway induced by RSV infection, reduced the production of inflammatory cytokines IL-1beta, IL-6 and TNF-alpha, and alleviate lung injury in young rats. +transcription factor target 35241643 hsa-mir-146a Aging, Premature This mutual inhibitory relationship between miR-146a and AMPK enriches our understanding of the molecular connections between AMPK and SIRT and provides new insight into miRNA-mediated NAD(+)/SIRT regulation and an intervention point for the prevention of aging and age-related diseases. +transcription factor target 35241643 hsa-mir-146a Aicardi-Goutieres syndrome 5 Furthermore, our results showed that miR-146a impedes the anti-aging effect of AMPK. This mutual inhibitory relationship between miR-146a and AMPK enriches our understanding of the molecular connections between AMPK and SIRT and provides new insight into miRNA-mediated NAD(+)/SIRT regulation and an intervention point for the prevention of aging and age-related diseases. +lncRNA target 35241511 hsa-mir-1 Prostatic Neoplasms MATERIALS AND METHODS: LNCaP or PC3 cells were treated with androgens or transfected with vectors containing microRNA-1 (miR-1), HSP60, HSP60-specific short-hairpin RNA (shHSP60), or a miR-1 inhibitor. +exosome 35241153 hsa-mir-100 Hemorrhage Mechanistically, our data suggested that SHED-Exos are enriched with miR5p and miR-1246 and are transferred to endothelial cells, which results in decreased tube formation via the down-regulation of VEGFA expression. +exosome 35241153 hsa-mir-1246 Hemorrhage Mechanistically, our data suggested that SHED-Exos are enriched with miR5p and miR-1246 and are transferred to endothelial cells, which results in decreased tube formation via the down-regulation of VEGFA expression. +other 35241117 hsa-mir-17 Urinary Bladder Neoplasms The pairs of miR5p (upregulated in BLCA tissues) and TGFBR2 (downregulated in BLCA tissues) were verified in the external validation cohort (28 BLCA vs. +genetics_overexpression_promote 35241106 hsa-mir-500a Colorectal Neoplasms Overexpression of CDK6 phenotypically rescued the inhibitory effect of miR-500a-3p on the proliferation and glycolysis of CRC cells. +lncRNA target 35241028 hsa-mir-873 Esophageal Squamous Cell Carcinoma CONCLUSION: These findings unraveled that hsa_circ_0000277 promoted ESCC progression and DDP resistance via miR +exosome 35240953 hsa-mir-29a Cardiomegaly Studies have reported an important role for miR-29a in regulating angiogenesis and pathological myocardial hypertrophy. However, whether CMderived exosomal miR-29a is involved in regulating cardiac microvascular endothelial cell (CMEC) homeostasis during myocardial hypertrophy has not been determined. +lncRNA target 35240924 hsa-mir-4311 Squamous Cell Carcinoma of Head and Neck Our study provides evidence that LINC00472 plays an essential role in inhibiting oral squamous cell carcinoma progression and affecting immune responses by directly binding to hsa-miR-4311 to regulate the expression of GNG7 positively. +lncRNA target 35240920 hsa-mir-146a Stomach Neoplasms Altogether, HCG18 promotes GC progression via the miR-146a-5p/TRAF6 axis and could be a GC treatment target. +circRNA target 35240495 hsa-mir-296 Breast Neoplasms In conclusion, the tumor-promoting role of circ_002172 in BC was achieved by inducing immune escape via the miR +genetics_knock down_promote 35240453 hsa-mir-149 Uterine Cervical Neoplasms 5p overexpression on angiogenesis and malignant behaviors of CC cells. +transcription factor target 35240295 hsa-mir-190 Autoimmune Diseases Collectively, these results provide strong evidence for an important regulatory mechanism of miR-103 and miR-190 targeting the IL-1R1 gene, thereby preventing excessive inflammatory immune responses from causing autoimmunity. +transcription factor target 35240295 hsa-mir-103 Autoimmune Diseases Collectively, these results provide strong evidence for an important regulatory mechanism of miR-103 and miR-190 targeting the IL-1R1 gene, thereby preventing excessive inflammatory immune responses from causing autoimmunity. +other 35240232 hsa-mir-193b Colorectal Neoplasms Among the miRNAs regulated by TRF2, we focused on miR-193b-3p, an oncomiRNA that positively correlates with TRF2 expression in human colorectal cancer patients from The Cancer Genome Atlas dataset. +other 35240034 hsa-mir-155 Myocarditis Myocarditis has been linked with microRNA-221/222 (miR-221/222), miR-155, miR-10a*, and miR-590. +other 35240034 hsa-mir-221 Myocarditis Myocarditis has been linked with microRNA-221/222 (miR-221/222), miR-155, miR-10a*, and miR-590. +other 35240034 hsa-mir-10a Myocarditis Myocarditis has been linked with microRNA-221/222 (miR-221/222), miR-155, miR-10a*, and miR-590. +transcription factor target 35239776 hsa-mir-23a Sepsis Upregulation of miR-23a-3p may alleviate LPS-induced cell injury by targeting wnt5a and inactivating Wnt/beta-catenin pathway, which may serve as a novel therapeutic target for sepsis-associated AKI. +circulation_biomarker_diagnosis_ns 35239506 hsa-mir-382 Renal Insufficiency, Chronic Five microRNAs were mutually differentially expressed between ischemic and contralateral kidneys and baseline and end point serum, with 4 (mir-21, mir-146, mir-199, and mir-235) having increased expression in both the ischemic kidney and end point serum and 1 (mir-382) having increased expression in the ischemic kidney and decreased expression in end point serum. +circulation_biomarker_diagnosis_ns 35239506 hsa-mir-146 Renal Insufficiency, Chronic Five microRNAs were mutually differentially expressed between ischemic and contralateral kidneys and baseline and end point serum, with 4 (mir-21, mir-146, mir-199, and mir-235) having increased expression in both the ischemic kidney and end point serum and 1 (mir-382) having increased expression in the ischemic kidney and decreased expression in end point serum. +circulation_biomarker_diagnosis_ns 35239506 hsa-mir-21 Renal Insufficiency, Chronic Five microRNAs were mutually differentially expressed between ischemic and contralateral kidneys and baseline and end point serum, with 4 (mir-21, mir-146, mir-199, and mir-235) having increased expression in both the ischemic kidney and end point serum and 1 (mir-382) having increased expression in the ischemic kidney and decreased expression in end point serum. +circulation_biomarker_diagnosis_ns 35239506 hsa-mir-199 Renal Insufficiency, Chronic Five microRNAs were mutually differentially expressed between ischemic and contralateral kidneys and baseline and end point serum, with 4 (mir-21, mir-146, mir-199, and mir-235) having increased expression in both the ischemic kidney and end point serum and 1 (mir-382) having increased expression in the ischemic kidney and decreased expression in end point serum. +circulation_biomarker_diagnosis_ns 35239506 hsa-mir-235 Renal Insufficiency, Chronic Five microRNAs were mutually differentially expressed between ischemic and contralateral kidneys and baseline and end point serum, with 4 (mir-21, mir-146, mir-199, and mir-235) having increased expression in both the ischemic kidney and end point serum and 1 (mir-382) having increased expression in the ischemic kidney and decreased expression in end point serum. +target gene 35239148 hsa-mir-25 Esophageal Neoplasms Mir-25 Promotes Metastasis of Esophageal Cancer by Targeting BTG2. +genetics_overexpression_promote 35239093 hsa-mir-656 Nasopharyngeal Carcinoma 3p overexpression restrained NPC cell malignant phenotypes, while ELF2 elevation reversed the effects. +circRNA target 35239092 hsa-mir-876 Carcinoma, Non-Small-Cell Lung Circ_0016760 could promote the malignant development of NSCLC through miR +lncRNA target 35239064 hsa-mir-758 Breast Neoplasms In conclusion, circ_0008500 inhibition promoted the radiosensitivity and restrained the development of breast cancer by downregulating PFN2 expression via targeting miR +lncRNA target 35238915 hsa-mir-466b Leukoencephalopathies We conclude that miR-466b-5p is involved in the regulation of WMI pathogenesis, partly through the Lpar1/Edg2/Sox10 and Lpar1/Edg2/PLP signaling pathways. +other 35238896 hsa-mir-558 Gestational Trophoblastic Disease Circ_0007611 aggravated trophoblast cell disorders by the miR-558/IL1RAP pathway in PE. +other 35238896 hsa-mir-558 Pneumonia, Mycoplasma Circ_0007611 and IL1RAP expressions were significantly upregulated, while miR-558 was downregulated in the placental tissues of PE women in comparison with normal placental tissues. Circ_0007611 aggravated trophoblast cell disorders by the miR-558/IL1RAP pathway in PE. +lncRNA target 35238350 hsa-let-7f Atherosclerosis Here, we investigated the role of let-7f in hMSC tropism to human atheromas and the effects of the plaque microenvironment on cell fate and release of soluble factors. CONCLUSIONS: Our findings indicate that let-7f promotes hMSC tropism towards atheromas through the LL-37/FPR2 axis and demonstrate that hMSCs upon contact with human plaque environment develop a potentially athero-protective signature impacting the pathophysiology of atherosclerosis. +other 35238312 hsa-mir-1276 Aortic Valve Stenosis CONCLUSIONS: Our analysis suggested that IBSP, NCAM1, MMP9, FCGR3B, COL4A3, FCGR1A, THY1, RUNX2, ITGA4, and COL10A1 might be hub genes associated with AS, and hsa-miR-1276 was potential miRNA. +other 35238277 hsa-mir-340 Pancreatitis 5p to promote HMGB1 expression, which activates TLR4 expression and promotes myocardial injury in rats with SAP. +other 35238277 hsa-mir-340 Cardiomyopathies 5p to promote HMGB1 expression, which activates TLR4 expression and promotes myocardial injury in rats with SAP. +lncRNA target 35238066 hsa-mir-411 Prostatic Neoplasms 5p directly targeted PGK1, and miR +genetics_knock down_promote 35238054 hsa-mir-497 Prostatic Neoplasms In conclusion, TRPM2-AS knockdown suppressed cell progression and PTX resistance in PTX-resistant PCa cells by miR +circulation_biomarker_prognosis_ns 35237856 hsa-mir-200a Breast Neoplasms Our results encourage the use of circulating miR-200s as valuable prognostic biomarkers during metastatic breast cancer therapy. +lncRNA target 35237695 hsa-mir-582 Carcinoma, Hepatocellular CONCLUSION: TUG1 increases the Siglec-15 level in HCC cells as a sponge to hsa-miR5p, resulting in enhanced immunosuppression. +circulation_biomarker_diagnosis_ns 35237654 hsa-mir-106a Ischemic Stroke At the same time, we found marked increases of serum TUG1, LINC00657, and miR-9 and a marked decrease of serum miR-106a in diabetic patients who had stroke relative to those without stroke. +circulation_biomarker_diagnosis_ns 35237654 hsa-mir-106a Diabetes Mellitus, Type 2 At the same time, we found marked increases of serum TUG1, LINC00657, and miR-9 and a marked decrease of serum miR-106a in diabetic patients who had stroke relative to those without stroke. +lncRNA target 35237522 hsa-mir-493 Esophageal Squamous Cell Carcinoma Using bioinformatics tools, we saw miR5p as the direct molecular target of LINC00324 and interacted with the MAPK signaling pathway in ESCC pathogenesis. +transcription factor target 35237382 hsa-mir-672 Spinal Cord Injuries These results indicated that sh-miR3p exerted a neural restoration effect in vivo and in vitro by inhibiting ferroptosis via the FSP1 pathway. +lncRNA target 35237322 hsa-mir-200 Carcinoma, Hepatocellular CONCLUSION: Our study showed meloxicam inhibited HCC progression and enhanced the sensitivity of immunotherapy via the microRNA-200/PD-L1 pathway. +genetics_knock down_promote 35237319 hsa-mir-766 Prostatic Neoplasms 5p inhibition largely restores NEAT1 downregulation-mediated function on PCa progression, while E2F3 knockdown partly removes the effects of miRNA +other 35237223 hsa-mir-24 Friedreich Ataxia 3p-CD28 may be the potential RNA regulatory pathway related to the pathogenesis of child and adult FRDA. +other 35237086 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck 5p, and miR-21) for the detection of TSCC was confirmed. +other 35237086 hsa-mir-139 Squamous Cell Carcinoma of Head and Neck 5p, and miR-21) for the detection of TSCC was confirmed. +other 35237086 hsa-mir-486 Squamous Cell Carcinoma of Head and Neck 5p, and miR-21) for the detection of TSCC was confirmed. +genetics_overexpression_promote 35236936 hsa-mir-10b Carcinoma, Hepatocellular RESULTS: Sorafenib-induced apoptosis in HCC cells was significantly enhanced by miR-10b-3p overexpression and partially abrogated by miR-10b-3p depletion. +lncRNA target 35236826 hsa-mir-183 Carcinoma, Hepatocellular Collectively, our findings suggest the crucial role of the miR5p.1/MUC15/c-MET/PI3K/AKT/SOX2 regulatory circuit in regulating liver T-ICs properties, suggesting potential therapeutic targets for HCC. +genetics_knock down_promote 35236654 hsa-mir-127 Ovarian Neoplasms 3p could restore the effects of mifepristone on the proliferation and apoptosis of SKOV3 cells and A2780 cells, as well as the expression of PD-L1, CyclinD1, Cl-caspase-3 and Bax protein; our study confirmed that mifepristone can regulate the expression of VAMP2 and PD-L1 through miR +circulation_biomarker_diagnosis_ns 35236644 hsa-mir-148a Endometriosis The expression of miR-148a in serum of EMS patients was decreased, and miR-148a targets ADAMTS5 to promote apoptosis in EMS cells. +genetics_overexpression_promote 35236339 hsa-mir-140 Diabetes Mellitus 3p overexpressed-Exos accelerated diabetic wound healing by promoting the osteoblastogenesis function of BMSCs through inhibition plexin B1 expression which is the receptor of Sema4D and the plexin B1/RhoA/ROCK pathway compared with diabetes mellitus-Exos. +genetics_overexpression_promote 35236289 hsa-mir-152 Carcinoma, Hepatocellular 3p mimics were counteracted by overexpression of ROBO1 in HCC cells. +lncRNA target 35236255 hsa-mir-137 Intervertebral Disc Degeneration This study aimed to investigate the role played by microRNA (miR)-137 in intervertebral disc degeneration via targeting activin A receptor type I (ACVR1) and the underlying mechanism. +genetics_knock down_promote 35236250 hsa-mir-134 Squamous Cell Carcinoma of Head and Neck In addition, knockdown of EGFR or overexpression of miR +lncRNA target 35236239 hsa-mir-136 Dehydration This research aims to explore whether Res inhibits miR5p expression, increases heme oxygenase 1 (HMOX1) expression, and mitigates oxidative stress and PC12 cell apoptosis triggered by paraquat (PQ). +transcription factor target 35235816 hsa-mir-200c Breast Neoplasms The purpose of this paper is to examine the outcome of miR-200c restoring on enhancing the BC cells' sensitivity to Doxorubicin through downregulating the MDR1 expression. +other 35235759 hsa-mir-144 Heart Failure In addition, hsa-miR3p and CCNE2 may be considered as potential diagnostic gene biomarkers in HF. +other 35235759 hsa-mir-144 Cardiomyopathies In addition, hsa-miR3p and CCNE2 may be considered as potential diagnostic gene biomarkers in HF. +lncRNA target 35235755 hsa-mir-335 Atherosclerosis Herein, it appears that the LncRNA DANCR was closely associated with the progression of atherosclerosis by targeting miR5p, which might be a potential detective predictor and target for the treatment of atherosclerosis. +genetics_overexpression_promote 35235752 hsa-mir-940 Stomach Neoplasms 5p were overexpressed in GA, while mature miR +genetics_overexpression_suppress 35235474 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck 5p was significantly overexpressed in HNSCC compared to healthy tissues (P < .05) and showed potent predictive power with a summary receiver operating characteristic of 0.90. +lncRNA target 35235468 hsa-mir-21 Wounds and Injuries By investigating the healing mechanism, it was found that CPPM increased the hydroxyproline content in granulation tissue and had an excellent antioxidant ability, and then inhibited lipid peroxidation, in addition, it significantly increased the transcript levels of VEGF and miRNA-21 genes, indicating that CPPM play an influential role in vascular remodeling during wound healing by up-regulating the expression of VEGF and miRNA-21 genes. +other 35235435 hsa-let-7 Memory Disorders The LPS group also showed an increase in the inflammatory markers tumor necrosis factor-alpha and nuclear factor kappa B and downregulation of miR-146a and miR-let 7 expressions in the brain cells compared to the normal group, P value <.05. +other 35235435 hsa-let-7 Neurogenic Inflammation The LPS group also showed an increase in the inflammatory markers tumor necrosis factor-alpha and nuclear factor kappa B and downregulation of miR-146a and miR-let 7 expressions in the brain cells compared to the normal group, P value <.05. +genetics_overexpression_suppress 35235424 hsa-mir-195 Wounds and Injuries Decreased ARP-2 levels by miR-195 overexpression were associated with an inhibition of early epithelial restitution, as indicated by a decrease in cell migration over the wounded area. +genetics_overexpression_promote 35235236 hsa-mir-654 Breast Neoplasms 5p, resulting in overexpression of MEF2D in BCSCs. +circRNA target 35235125 hsa-mir-532 Uterine Cervical Neoplasms The circWHSC1-mediated miR3p/LTBP2 signaling axis might be a novel therapeutic target for CaCx. +lncRNA target 35234989 hsa-mir-136 Triple Negative Breast Neoplasms Si-circPTK2, mimic and inhibitor of miR-136 were transfected in TNBC cells to confirm the mechanism of circPTK2 and miR-136 in TNBC cells. +other 35234284 hsa-mir-203b Obesity miRNA-mRNA pairing analysis identified an association between 4 miRNAs (miR-759, miR-9a-3p, miR-203b-3p, and miR-878) that were differentially expressed in the obesity and control groups and 7 genes (Ly86, Arid5b, Rgs18, Mlana, P2ry13, Kif1b, and Myt1) expressed in gingival tissue. +other 35234284 hsa-mir-9a Obesity miRNA-mRNA pairing analysis identified an association between 4 miRNAs (miR-759, miR-9a-3p, miR-203b-3p, and miR-878) that were differentially expressed in the obesity and control groups and 7 genes (Ly86, Arid5b, Rgs18, Mlana, P2ry13, Kif1b, and Myt1) expressed in gingival tissue. +genetics_overexpression_suppress 35234260 hsa-mir-374c Carcinoma, Hepatocellular In vivo, it was found that overexpression of miR374c5p significantly inhibited the growth and proliferation of HCC cells. +circulation_biomarker_diagnosis_ns 35234251 hsa-mir-885 Liver Diseases Specifically, the authors profiled circulating miRNAs in patients with hepatocellular carcinoma (HCC), liver cirrhosis (LC), and healthy controls and found that serum miR5p levels were significantly higher in samples of patients with HCC (6.5-fold increase) and LC (8.8-fold increase). +genetics_overexpression_promote 35234205 hsa-mir-130a Sepsis-Associated Encephalopathy Results: Here our results described that YY1 and TREM-2 were downregulated and miR-130a-3p was upregulated in SAE. Conclusion: Taken together, YY1 promoted microglia M2 polarization via upregulating TREM-2 by interacting with miR-130a-3p promoter, suggesting YY1 overexpression might be a novel therapeutic strategy of SAE. +lncRNA target 35233882 hsa-mir-147a Uterine Cervical Neoplasms CONCLUSION: LncRNA OIP5-AS1 promotes the migration, invasion and EMT of cervical cancer cells via targeting miR-147a/IGF1R pathway. +genetics_knock down_promote 35233464 hsa-mir-206 Stomach Neoplasms CONCLUSION: circ_AKT3 knockdown suppressed cisplatin resistance using miR-206/PTPN14 axis in cisplatin-resistant GC cells. +genetics_overexpression_promote 35233463 hsa-mir-4673 Pancreatic Carcinoma The overexpression of SLCO4A1-AS1 aggravated the malignant behaviors of PC via the upregulation of KIF21B by sponging miR-4673. +circulation_biomarker_diagnosis_ns 35232961 hsa-mir-486 Pulmonary Disease, Chronic Obstructive The combination of plasma miR +other 35232557 hsa-mir-153 Diabetic Nephropathies 3p was lower in diabetic nephropathy patients, while the expression of PAQR3 was concomitantly higher. +genetics_overexpression_promote 35232010 hsa-mir-151 Glioma Additionally, overexpression of miR-151 also suppressed the migration and invasion of the human glioma cells. +other 35231919 hsa-mir-17 Carcinoma, Transitional Cell 5p) that were relevant for UCa diagnosis, and successfully developed a panel using three of these miRNAs. +other 35231919 hsa-mir-224 Carcinoma, Transitional Cell 5p) that were relevant for UCa diagnosis, and successfully developed a panel using three of these miRNAs. +other 35231919 hsa-mir-145 Carcinoma, Transitional Cell 5p) that were relevant for UCa diagnosis, and successfully developed a panel using three of these miRNAs. +circulation_biomarker_diagnosis_ns 35231918 hsa-mir-338 psoriasis 1 5p was highly expressed in the clinical serum samples from psoriasis patients. +lncRNA target 35231647 hsa-mir-183 Adenomyosis CONCLUSION: In general, we are the first to disclose the distinction of miR-183 and MMP-9 expressions in adenomyosis after we elucidated miR-183's role in epithelium's viability, migration and invasion . +other 35231462 hsa-mir-9 Neurotoxicity Syndromes Here, RSV was found to upregulate miR5p expression and downregulate MeHg-induced neurotoxicity, thereby minimizing cytotoxicity in primary hippocampal neurons and effectively attenuating MeHg-induced neurotoxicity. +genetics_overexpression_suppress 35231441 hsa-mir-125 Intervertebral disc disease 5p was low expression, while SUV39H1 was overexpressed in IDD. +other 35231061 hsa-mir-590 Myocardial Infarction, Acute By searching the literature in PubMed, we concluded that AQP9, IL1B, and IL1RN could be used as gene markers for AMI, while FSTL3-miR3303p-IL1B/IL1RN and ACSL4-miR5905p-IL1B could be used as RNA regulatory pathways affecting AMI disease progression. +circRNA target 35230926 hsa-mir-1200 Colonic Neoplasms In conclusion, circRNA_0085315 serves as a ceRNA and promotes CC progression through the activation of the MAPK signaling pathway mediated via the miR-1200/MAP3K1 axis, suggesting that circRNA_0085315 may be a promising diagnostic and therapeutic target for CC. +genetics_knock down_promote 35230916 hsa-mir-615 Fibrosis, Renal This study demonstrated that the overexpression of lncRNA4474 may attenuate fibrosis progression, accompanied by the downregulation of miR-615 and upregulation of HNF-1beta. +lncRNA target 35230909 hsa-mir-27b Ovarian Neoplasms LINC01234 regulates miR-27b-5p to induce the migration, invasion and self-renewal of OCSCs through targeting SIRT5. +circulation_biomarker_diagnosis_down 35230891 hsa-mir-501 Sepsis 5p expression was down-regulated in peripheral blood samples of septic patients with cardiac dysfunction, lipopolysaccharide (LPS)-induced cardiomyocytes, and the myocardium and peripheral blood in the septic model. +other 35230810 hsa-mir-141 Prostatic Neoplasms In this work, a new electrochemiluminescence (ECL) platform was constructed for detecting the prostate cancer marker microRNA-141 (miRNA-141) on a constant resistor-integrated closed bipolar electrode (BPE). +lncRNA target 35230201 hsa-mir-942 Carcinoma, Non-Small-Cell Lung circPTK2 (hsa_circ_0008305) and TRIM16 were low expressed, while miR-942 was significantly highly expressed in NSCLC tissues and cell lines. Furthermore, circPTK2 weakened CDDP resistance of NSCLC through modulating miR-942/TRIM16 axis, providing a novel sight for the treatment of NSCLC and improving the understanding of the CDDP resistance mechanism of NSCLC. +other 35230198 hsa-mir-197 Lung Neoplasms 3p was able to differentiate patients of lung adenocarcinoma from lung squamous cell carcinoma. +other 35230198 hsa-mir-375 Lung Neoplasms 3p was able to differentiate patients of lung adenocarcinoma from lung squamous cell carcinoma. +exosome 35229987 hsa-mir-122 osteogenesis imperfecta type 1 miRNA-seq found that exosomal miR +lncRNA target 35229638 hsa-mir-223 COVID-19 These results confirmed the contribution of miRNA-223 to the regulation of SARS-CoV-induced pathogenic processes and support the therapeutic potential of inhibiting miRNAs during coronavirus infection using RNA interference approaches. +lncRNA target 35229638 hsa-mir-223 Acute Kidney Injury These results confirmed the contribution of miRNA-223 to the regulation of SARS-CoV-induced pathogenic processes and support the therapeutic potential of inhibiting miRNAs during coronavirus infection using RNA interference approaches. +circulation_biomarker_diagnosis_ns 35229538 hsa-mir-143 Aortopathies Further, the multivariate logistic regression analysis revealed an association between blood and aortic tissue miR-143 levels each other (Odds Ratio [OR] 1.29, 95% Confidence Interval [CI] 1.11-1.67, p = 0.02; OR 1.36, 95% CI 1.19-2.01, p = 0.03, respectively) and a blood/aortic miR-143 level to dilated aorta (OR 3.61, 95% CI 1.62-9.02, p = 0.01; OR 2.92, 95% CI 1.81-7.05, p = 0.02, respectively). +circulation_biomarker_diagnosis_ns 35229538 hsa-mir-1 Aortopathies Further, the multivariate logistic regression analysis revealed an association between blood and aortic tissue miR-143 levels each other (Odds Ratio [OR] 1.29, 95% Confidence Interval [CI] 1.11-1.67, p = 0.02; OR 1.36, 95% CI 1.19-2.01, p = 0.03, respectively) and a blood/aortic miR-143 level to dilated aorta (OR 3.61, 95% CI 1.62-9.02, p = 0.01; OR 2.92, 95% CI 1.81-7.05, p = 0.02, respectively). +other 35229372 hsa-let-7c Colorectal Neoplasms Expressions of miRNA, miR-200a and let-7c were significantly higher in adenomas than normal tissues (p = .008 and p = .045 respectively). +other 35229372 hsa-mir-200a Colorectal Neoplasms Expressions of miRNA, miR-200a and let-7c were significantly higher in adenomas than normal tissues (p = .008 and p = .045 respectively). +genetics_knock down_suppress 35229272 hsa-mir-1306 Alzheimer Disease CircAXL knockdown alleviates Abeta(1-42)-induced neurotoxicity in AD pathology via repressing PDE4A by releasing miR +genetics_overexpression_promote 35229031 hsa-mir-876 Nasopharyngeal Carcinoma 5p overexpression or NETO2 downregulation had inhibitory effects on cell proliferation, migration, and invasion in NPC. +exosome 35229026 hsa-mir-1294 Carcinoma, Non-Small-Cell Lung Thus, exosomal circSHKBP1 participated in the progression of NSCLC via the miR-1294/PKM2 axis. +transcription factor target 35228896 hsa-mir-141 Colorectal Neoplasms Our study indicates that ANG regulates CRC progression by disrupting miR-141 and its regulation on angiogenesis-related target genes, not only revealing a new mechanism of ANG action but also newly identifying miR-141 as a substrate of ANG. +circulation_biomarker_diagnosis_ns 35228564 hsa-mir-126 ST Elevation Myocardial Infarction Plasma miR-30e can indicate the risk of no-reflow during primary percutaneous coronary intervention (pPCI), while miR-126 can be used as a predictor of coronary slow flow phenomenon. +circulation_biomarker_diagnosis_up 35228564 hsa-mir-155 ST Elevation Myocardial Infarction Elevated MALAT1, CRP, HPSE, and EDN1 expression and suppressed miR-30e, miR-155 and miR-126 expression was found in the plasma of STEMI patients receiving pPCI who were diagnosed with no-reflow phenomenon. +lncRNA target 35228520 hsa-mir-32 Prostatic Neoplasms In conclusion, we show that miR-32 promotes MYC-induced prostate adenocarcinoma and identifies PDK4 as a PC-relevant metabolic target of miR +exosome 35228162 hsa-mir-1287 Carcinoma, Non-Small-Cell Lung Exosome circ_0048856 promoted the NSCLC development by targeting miR +circRNA target 35227787 hsa-mir-339 Prostatic Neoplasms 5p/STAT5A axis, and it may function as a potential prognostic biomarker or therapeutic target for PCa treatment. +genetics_overexpression_suppress 35227681 hsa-mir-340 Squamous Cell Carcinoma of Head and Neck 3p overexpression inhibited while down-regulation of miR +other 35227173 hsa-mir-106a Nasopharyngeal Carcinoma In addition, downregulation of microRNA 106a-5p (miR-106a-5p) expression and upregulation of SRY-box transcription factor 4 (SOX4) expression were observed in DDP-resistant NPC tissues and cells. In summary, HOTAIR enhanced DDP resistance in NPC cells by regulating the miR-106a-5p/SOX4 axis. +genetics_GWAS 35227165 hsa-mir-146a COVID-19 Then, miRNA-146a rs2910164 GC single-nucleotide polymorphism (SNP) was genotyped in a larger group of COVID-19 patients (n = 129), and its relationship with severe disease [Intensive Care Unit (ICU) support or survival/death] was assessed. +lncRNA target 35226830 hsa-mir-200b Stomach Neoplasms In conclusion, miR-200b-3p inhibited GC progression via regulating CXCL12/CXCR7 axis. +circulation_biomarker_diagnosis_up 35226820 hsa-mir-29b Sjogren's Syndrome Our results revealed that KCNQ1OT1 was downregulated while miR-29b-3p was upregulated in the serum samples of OM patients, as well as in SpA-infected hBMSCs. +circulation_biomarker_diagnosis_up 35226820 hsa-mir-29b Otitis Media We first examined the expression of lncRNA KCNQ1OT1 and miR-29b-3p in the serum samples of OM patients and healthy controls. Our results revealed that KCNQ1OT1 was downregulated while miR-29b-3p was upregulated in the serum samples of OM patients, as well as in SpA-infected hBMSCs. +other 35226820 hsa-mir-29b Pneumonia, Staphylococcal In the present study, we investigated the role of KCNQ1OT1/miR-29b-3p axis in osteogenic differentiation in staphylococcus aureus (SpA)-infected human bone mesenchymal stem cells (hBMSCs). +other 35226820 hsa-mir-29b Bone Diseases In the present study, we investigated the role of KCNQ1OT1/miR-29b-3p axis in osteogenic differentiation in staphylococcus aureus (SpA)-infected human bone mesenchymal stem cells (hBMSCs). +circulation_biomarker_diagnosis_ns 35226566 hsa-mir-199a Plaque, Atherosclerotic Circulating levels of miR-15a-5p, miR-30e-5p, miR-92a-3p, miR-199a-3p, miR +other 35226566 hsa-mir-93 Plaque, Atherosclerotic Following exercise intervention, decreased levels of miR-15a-5p, miR5p, and miR-451a, and increased levels of miR-146a-5p were associated with an observed regression of coronary plaque burden. +circulation_biomarker_diagnosis_ns 35226566 hsa-mir-222 Plaque, Atherosclerotic Circulating levels of miR-15a-5p, miR-30e-5p, miR-92a-3p, miR-199a-3p, miR +other 35226566 hsa-mir-451a Plaque, Atherosclerotic Following exercise intervention, decreased levels of miR-15a-5p, miR5p, and miR-451a, and increased levels of miR-146a-5p were associated with an observed regression of coronary plaque burden. +circulation_biomarker_diagnosis_ns 35226566 hsa-mir-221 Plaque, Atherosclerotic Circulating levels of miR-15a-5p, miR-30e-5p, miR-92a-3p, miR-199a-3p, miR +other 35226566 hsa-mir-15a Plaque, Atherosclerotic Following exercise intervention, decreased levels of miR-15a-5p, miR5p, and miR-451a, and increased levels of miR-146a-5p were associated with an observed regression of coronary plaque burden. +circulation_biomarker_diagnosis_ns 35226566 hsa-mir-92a Plaque, Atherosclerotic Circulating levels of miR-15a-5p, miR-30e-5p, miR-92a-3p, miR-199a-3p, miR +transcription factor target 35226449 hsa-mir-139 Kidney Neoplasms The expression of miR-139 was found to be significantly (P<0.05) downregulated in human kidney cancer cells lines. Taken together, the results revealed that CXCR/miR-139 axis regulates the proliferation, migration, and invasion of human kidney cancer cells and may act as a therapeutic target. +other 35226160 hsa-mir-383 Polycystic Ovary Syndrome 5p had sufficient potential for prediction of PCOS. +other 35225755 hsa-mir-613 Osteoarthritis Collectively, circ_0020014 acted as a miR-613 sponge to regulate ADAMTS5 expression, thereby protecting chondrocytes from IL-1beta-induced inflammatory damage, which might be a novel diagnostic marker for OA. +genetics_knock down_promote 35225648 hsa-mir-193a Lung Neoplasms And IRF4 overexpression reversed miR-193a-3p mimic-mediated effects on NSCLC cell malignancy, autophagy, and glycolysis. +genetics_knock down_promote 35225648 hsa-mir-193a Carcinoma, Non-Small-Cell Lung And IRF4 overexpression reversed miR-193a-3p mimic-mediated effects on NSCLC cell malignancy, autophagy, and glycolysis. +genetics_overexpression_promote 35225486 hsa-mir-92a Colorectal Neoplasms RESULTS: Statistically significant overexpression of serum miR-92a was observed in CRC patients as compared to adenoma and control groups (p<0.001 each) and lower serum Bim in CRC patients as compared to adenoma and control groups (p=0.001, p <0.001 respectively). +lncRNA target 35224785 hsa-mir-940 Carcinoma, Hepatocellular LncRNA THEMIS2-211 exerts its biological function as an oncogene that promotes the proliferation, migration, invasion, EMT of HCC cells by physically interacting with miR-940 and therefore promoting SPOCK1 expressions. The discovery of lncRNA THEMIS2-211 further illuminates the molecular pathogenesis of HCC and the THEMIS2-211/miR-940/SPOCK1 axis may act as a potential therapeutic target for HCC. +other 35224615 hsa-mir-144 Diabetes, Gestational In those regulatory axes, the MALAT1/hsa-miR3p/IRS1 axis was predicted to be the key axis and was identified as being associated with GDM for the first time. +other 35224317 hsa-mir-122 Liver Cirrhosis The combination of miR-122 and miR-150 has the potential as a biomarker to differentiate HCC from liver cirrhosis. +other 35224317 hsa-mir-150 Carcinoma, Hepatocellular The combination of miR-122 and miR-150 has the potential as a biomarker to differentiate HCC from liver cirrhosis. +other 35224317 hsa-mir-150 Liver Cirrhosis The combination of miR-122 and miR-150 has the potential as a biomarker to differentiate HCC from liver cirrhosis. +other 35224317 hsa-mir-122 Carcinoma, Hepatocellular The combination of miR-122 and miR-150 has the potential as a biomarker to differentiate HCC from liver cirrhosis. +target gene 35224289 hsa-mir-19b Lung Neoplasms Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis. +other 35223986 hsa-mir-106b Squamous Cell Carcinoma of Head and Neck Herein, we developed a surface-enhanced Raman scattering (SERS)-based lateral flow assay (LFA) biosensor, assisted with catalytic hairpin assembly (CHA) amplification strategy, for the dynamic monitoring of miR-106b and miR-196b, associated with laryngeal squamous cell carcinoma (LSCC). +other 35223986 hsa-mir-196b Squamous Cell Carcinoma of Head and Neck Herein, we developed a surface-enhanced Raman scattering (SERS)-based lateral flow assay (LFA) biosensor, assisted with catalytic hairpin assembly (CHA) amplification strategy, for the dynamic monitoring of miR-106b and miR-196b, associated with laryngeal squamous cell carcinoma (LSCC). +circulation_biomarker_diagnosis_ns 35223564 hsa-mir-21 Asthma BACKGROUND: This research was designed to probe into the role of miRNA-21 in the pathogenesis of childhood asthma and its correlation with the severity. RESULTS: Compared with that of healthy children, the miR-21 expression in peripheral blood serum of asthmatic children was higher (P<0.001). +transcription factor target 35223454 hsa-mir-100 Urinary Bladder Neoplasms 5p in BC, that might represent not only a useful biomarker for improved diagnosis and patients' stratification but also as a promising axis that might be therapeutically targeted in situ. +transcription factor target 35223454 hsa-mir-138 Urinary Bladder Neoplasms 5p in BC, that might represent not only a useful biomarker for improved diagnosis and patients' stratification but also as a promising axis that might be therapeutically targeted in situ. +genetics_overexpression_suppress 35223452 hsa-mir-22 Carcinoma, Mucoepidermoid Two overexpressed miRNAs in MEC (miR-22 and miR-205) were selected for inhibition by the CRISPR-Cas9 method. +genetics_overexpression_suppress 35223452 hsa-mir-205 Carcinoma, Mucoepidermoid Two overexpressed miRNAs in MEC (miR-22 and miR-205) were selected for inhibition by the CRISPR-Cas9 method. +other 35223094 hsa-mir-197 Sepsis Studies have found that miR-197 is correlated with the prognosis of patients with inflammatory heart disease, but its effect on sepsis-induced cardiomyocyte injury remains unclear. miR-197 contributed to LPS-induced cardiomyocyte injury by modulating SIRT1, which might be used as a molecular marker in the management of sepsis. +other 35223094 hsa-mir-197 Myocarditis Studies have found that miR-197 is correlated with the prognosis of patients with inflammatory heart disease, but its effect on sepsis-induced cardiomyocyte injury remains unclear. +other 35223093 hsa-mir-654 Coronary Artery Disease 5p), and eight mRNAs (MKRN1, UBE2H, UBE2W, UBE2D1, UBE2F, BE2J1, ZNRF1, and SIAH2). +other 35223093 hsa-mir-411 Coronary Artery Disease 5p), and eight mRNAs (MKRN1, UBE2H, UBE2W, UBE2D1, UBE2F, BE2J1, ZNRF1, and SIAH2). +other 35223093 hsa-mir-136 Coronary Artery Disease 5p), and eight mRNAs (MKRN1, UBE2H, UBE2W, UBE2D1, UBE2F, BE2J1, ZNRF1, and SIAH2). +other 35223093 hsa-mir-376c Coronary Artery Disease 5p), and eight mRNAs (MKRN1, UBE2H, UBE2W, UBE2D1, UBE2F, BE2J1, ZNRF1, and SIAH2). +lncRNA target 35222878 hsa-mir-146a Pancreatic Carcinoma In summary, we found miR-146a reduced the cell proliferation of pancreatic cancer through targeting SOX7. +other 35222845 hsa-mir-142 Prostatic Neoplasms 3p in PC samples with GS 9. +other 35222845 hsa-mir-296 Prostatic Neoplasms 3p in PC samples with GS 9. +other 35222845 hsa-mir-155 Prostatic Neoplasms 3p in PC samples with GS 9. +lncRNA target 35222806 hsa-mir-155 Hypoxia-Ischemia, Brain 5p in CPE-derived EVs can aggravate IBI pathology by suppressing Rheb expression and promoting NLRP3-mediated inflammasomes, suggesting its role as a potential therapeutic target in IBI. +lncRNA target 35222806 hsa-mir-155 Inflammation 5p in CPE-derived EVs can aggravate IBI pathology by suppressing Rheb expression and promoting NLRP3-mediated inflammasomes, suggesting its role as a potential therapeutic target in IBI. +lncRNA target 35222806 hsa-mir-15 Hypoxia-Ischemia, Brain 5p in CPE-derived EVs can aggravate IBI pathology by suppressing Rheb expression and promoting NLRP3-mediated inflammasomes, suggesting its role as a potential therapeutic target in IBI. +lncRNA target 35222806 hsa-mir-15 Inflammation 5p in CPE-derived EVs can aggravate IBI pathology by suppressing Rheb expression and promoting NLRP3-mediated inflammasomes, suggesting its role as a potential therapeutic target in IBI. +transcription factor target 35222797 hsa-mir-483 Hypertension These findings suggest that miR3p exerts a protective effect on EC function during the onset of hypertension and thus may be considered a potential therapeutic target for hypertension-related cardiovascular diseases. +lncRNA target 35222741 hsa-mir-24 Coronary Artery Disease CONCLUSIONS: LINC00460 regulates the proliferative ability of ECs and thus the occurrence and development of coronary atherosclerotic diseases by targeting miRNA3p. +lncRNA target 35222723 hsa-mir-425 Squamous Cell Carcinoma of Head and Neck Collectively, the findings of the present study demonstrated that lncRNA HCG22 may inhibit the proliferation, invasion and migration of OSCC cells by downregulating miR +target gene 35222721 hsa-mir-455 Colorectal Neoplasms Circular RNA, hsa_circRNA_102049, promotes colorectal cancer cell migration and invasion via binding and suppressing miRNA-455-3p. +other 35222718 hsa-mir-615 Alzheimer Disease 3p may be potential biomarkers in the early diagnosis of AD. +lncRNA target 35222713 hsa-mir-9 Diabetic Nephropathies At the molecular level, TUG1 was revealed to promote sirtuin 1 (SIRT1) expression by sponging microRNA (miR)-9, and SIRT1 OE reversed the HG-induced apoptosis and mitochondrial dysfunction increased by TUG1 KD. The present data indicated that downregulation of TUG1 induced by HG was associated with HG-induced apoptosis and mitochondrial dysfunction in podocytes, and that TUG1 protected HG-induced podocytes by promoting SIRT1 expression via miR-9 inhibition. +target gene 35222708 hsa-mir-146b Colorectal Neoplasms miR-146b-5p promotes colorectal cancer progression by targeting TRAF6. +other 35222688 hsa-mir-16 Multiple Myeloma After treatment, the levels of CD3+, CD4+, CD4+/CD8+, Treg, miRNA-15a, and miRNA-16 in the combined group were higher than those in the control group, and the levels of miRNA-21, M protein, and myeloma cells were lower than those in the control group, with statistical significance (P < 0.05). +other 35222688 hsa-mir-21 Multiple Myeloma After treatment, the levels of CD3+, CD4+, CD4+/CD8+, Treg, miRNA-15a, and miRNA-16 in the combined group were higher than those in the control group, and the levels of miRNA-21, M protein, and myeloma cells were lower than those in the control group, with statistical significance (P < 0.05). +other 35222688 hsa-mir-15a Multiple Myeloma After treatment, the levels of CD3+, CD4+, CD4+/CD8+, Treg, miRNA-15a, and miRNA-16 in the combined group were higher than those in the control group, and the levels of miRNA-21, M protein, and myeloma cells were lower than those in the control group, with statistical significance (P < 0.05). +target gene 35222643 hsa-mir-524 Carcinoma, Non-Small-Cell Lung EGFR-AS1 Promotes Nonsmall Cell Lung Cancer (NSCLC) Progression via Downregulating the miR-524-5p/DRAM1 Axis and Inhibiting Autophagic Lysosomal Degradation. +lncRNA target 35222538 hsa-mir-466 Myocardial Infarction Mirt1 acts as a ceRNA to bind to miR-466i-5p to further regulate the expression levels of the target gene, thereby aggravating cardiac remodeling after MI. +other 35222538 hsa-mir-466 Ichthyosis, Lamellar Co-expression network analysis identified two core lncRNAs (Mirt1 and AC125351.1) and two core microRNAs (miR-466i-5p and miR5p) during the development of CIH-exaggerated post-MI remodeling, and they were verified by quantitative real-time PCR (qRT-PCR). +exosome 35222263 hsa-mir-26b Polycystic Ovary Syndrome The study indicates that adipose tissue-derived extracellular vesicles-miR-26b may play a key role in the PCOS and also provides insight into developing new therapeutic strategies for PCOS. +lncRNA target 35222075 hsa-mir-122 Inflammation This study provides a novel finding that FOXO3 was the target gene of miR +lncRNA target 35222033 hsa-mir-21 Lipid Metabolism Disorders Inhibition of miR-21 expression or Fenofibrate (PPARalpha agonist) administration prevented the decrease of PPARalpha in renal tubular epithelial cells under high glucose (HG) and high fat (Palmitic acid, PA) conditions, alleviating lipid metabolism disorders and reducing mitochondrial dynamics and inflammation. Based on these observations, we conclude that Atorvastatin inhibits tubular epithelial cell injury in T1DM with concomitant induction of lipid metabolism disorders by a mechanism involving inhibition of miR-21 expression and consequent upregulation of PPARalpha expression. +lncRNA target 35222033 hsa-mir-21 Diabetic Nephropathies Inhibition of miR-21 expression or Fenofibrate (PPARalpha agonist) administration prevented the decrease of PPARalpha in renal tubular epithelial cells under high glucose (HG) and high fat (Palmitic acid, PA) conditions, alleviating lipid metabolism disorders and reducing mitochondrial dynamics and inflammation. Based on these observations, we conclude that Atorvastatin inhibits tubular epithelial cell injury in T1DM with concomitant induction of lipid metabolism disorders by a mechanism involving inhibition of miR-21 expression and consequent upregulation of PPARalpha expression. +other 35221916 hsa-mir-150 Epilepsy 5p with area under curve (AUC) values of 0.846, 0.835, and 0.826, respectively, were identified as promising biomarkers of epilepsy. +other 35221916 hsa-mir-342 Epilepsy 5p with area under curve (AUC) values of 0.846, 0.835, and 0.826, respectively, were identified as promising biomarkers of epilepsy. +other 35221916 hsa-mir-584 Epilepsy 5p with area under curve (AUC) values of 0.846, 0.835, and 0.826, respectively, were identified as promising biomarkers of epilepsy. +genetics_overexpression_promote 35220908 hsa-mir-186 Carcinoma, Non-Small-Cell Lung 3p facilitated cell apoptosis rate and autophagy substrates LC3BII and Beclin-1, but curbed the colony-formation and DNA replication ability of NSCLC, glucose consumption, lactic acid production, glycolytic rate-limiting enzyme HK-2 and glutamine hydrolase GLS1 and P62, while overexpressed circEHD2 was adverse. +other 35220907 hsa-mir-326 Carcinoma, Hepatocellular The data illustrated that circ_0008043 and RAB21 were highly expressed, while miR-326 was expressed at less levels in HCC tissues and cells. In summary, silencing of circ_0008043 impeded HCC progression by regulating the miR-326/RAB21 axis. +lncRNA target 35220889 hsa-mir-4262 Nasopharyngeal Carcinoma Salidroside can significantly inhibit the proliferation and promote the apoptosis of NPC cells via regulating miR-4262/GRP78 signal axis. +genetics_knock down_promote 35220878 hsa-mir-655 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma In conclusion, we confirmed for the first time that lncRNA EBLN3P is dysregulated in T-ALL cell lines, and lncRNA EBLN3P knockdown inhibited the malignant biological behaviors of T-ALL cells by up-regulating miR +genetics_knock down_suppress 35220873 hsa-mir-1256 Stomach Neoplasms The inhibition effect of circ_0008035 knockdown on the malignant behavior of GC cells could be reversed by miR-1256 inhibitor. Collectively, circ_0008035 regulated the expression of CEACAM6 by sponging miR-1256, thereby promoting the development of GC. +lncRNA target 35220863 hsa-mir-142 Acute Kidney Injury Our data revealed that p53 inhibition could attenuate cisplatin-induced acute kidney injury by up-regulating miR +genetics_knock down_promote 35220610 hsa-mir-1290 Prostatic Neoplasms We performed CCK-8, clone forming, Transwell, and sphere formation assays for examining PC cells' malignant phenotypes following miR-1290 knockdown. +other 35220397 hsa-mir-646 Squamous Cell Carcinoma of Head and Neck Functional experiments further revealed that miR-646 reversed the autophagy and apoptosis effects of circ-PKD2 in OSCC cells treated with cisplatin. +transcription factor target 35220277 hsa-mir-375 Carcinoma, Pancreatic Ductal In conclusion, amplification of AK4P1 may fuel the onset and development of PDAC by targeting YAP1 through competitively binding to miR-375, and serve as a promising biomarker and therapeutic target for PDAC. +genetics_knock down_promote 35219894 hsa-mir-29a Fibrosis Consistently, hepatic miR-29a loss and increased LC3 expression in myofibroblastic HSC were associated with increased serum miR-29a levels in CCl(4)-treated murine liver fibrosis and specimens of hepatitis C virus patients with chronic liver disease. +circulation_biomarker_diagnosis_ns 35219894 hsa-mir-29a Hepatitis C, Chronic Hepatic and serum miR-29a levels were quantified by using both liver tissue and serum samples from a cohort of chronic hepatitis C virus patients and a murine CCl(4) induced liver fibrosis model. +other 35219767 hsa-mir-34b Azoospermia, Nonobstructive In the miRNAs prediction, the hsa-miRNA-449a, hsa-miRNA-34c-5p and hsa-miRNA-34b-5p may be implicated in NOA. +other 35219767 hsa-mir-449a Azoospermia, Nonobstructive In the miRNAs prediction, the hsa-miRNA-449a, hsa-miRNA-34c-5p and hsa-miRNA-34b-5p may be implicated in NOA. +other 35219767 hsa-mir-34c Azoospermia, Nonobstructive In the miRNAs prediction, the hsa-miRNA-449a, hsa-miRNA-34c-5p and hsa-miRNA-34b-5p may be implicated in NOA. +genetics_overexpression_promote 35219754 hsa-mir-142 Alzheimer Disease RESULTS: Overexpressed miR +genetics_knock down_promote 35219686 hsa-mir-182 Glioma 5p overexpression. +genetics_knock down_promote 35219069 hsa-mir-361 Osteosarcoma 3p was demonstrated to promote the proliferation, migration and invasion of osteosarcoma cells; knockdown of miR +genetics_overexpression_promote 35218724 hsa-mir-198 Osteosarcoma E2F2 was a direct target of miR-198, and miR-198 overexpression regulated OS cell progression in vitro by down-regulating E2F2. +epigenetics 35218115 hsa-mir-141 Leukemia, Prolymphocytic, T-Cell Remarkably, we found strong upregulation of the miR-200c/-141 cluster in T-PLL to be associated with DNA hypomethylation and active promoter marks. +epigenetics 35218115 hsa-mir-200c Leukemia, Prolymphocytic, T-Cell Remarkably, we found strong upregulation of the miR-200c/-141 cluster in T-PLL to be associated with DNA hypomethylation and active promoter marks. +lncRNA target 35218109 hsa-mir-1270 Uterine Cervical Neoplasms CONCLUSION: KCNQ1OT1/miR-1270/LOXL2 axis modulated viability and apoptosis of cervical cancer cells. +genetics_knock down_promote 35217880 hsa-mir-376a Heart Failure Both miR-376a-3p knockdown and TRAF6 overexpression annulled the protective role of CREB1 overexpression in cardiac function of HF rats. +lncRNA target 35217336 hsa-mir-224 Cardiomyopathies CONCLUSION: Our study demonstrates that the KCNQ1OT1 suppresses myocardial injury via mediating miR +lncRNA target 35217336 hsa-mir-224 Myocardial Injury CONCLUSION: Our study demonstrates that the KCNQ1OT1 suppresses myocardial injury via mediating miR +other 35217024 hsa-mir-27b Fibrosis Cytochrome P(450) family 1, subfamily B, polypeptide 1 (CYP1B1), involved in metabolism of dietary toxins is negatively regulated by miR-27b and linked with the nuclear factor kappa B (NF-kappaB) pathway and peroxisome proliferator activated receptor gamma (PPAR) in renal fibrosis. +lncRNA target 35216934 hsa-mir-539 Triple Negative Breast Neoplasms CONCLUSION: LINC00466 promotes the progression of TNBC via regulating miR +genetics_overexpression_promote 35216636 hsa-mir-365 Squamous Cell Carcinoma of Head and Neck Overexpression of CASC15 and cyclin D1 led to promoted, while overexpression of miR-365 led to inhibited LSCC cell proliferation. +genetics_GWAS 35216394 hsa-mir-193a Ovarian Neoplasms When applied to estrogen receptor signaling pathways, the miR-193a targets E2F6 (a target of estrogen receptor), c-KIT (a marker for cancer stemness), and PBX1 (a transcriptional activator for immunosuppressive cytokine, IL-10) in ovarian cancer, such that epigenetic silencing of miR-193a by E2F6 protein is required for the significant change of c-KIT and PBX1 mRNA level for cancer stemness and immunoevasion, respectively, in ovarian cancer carcinogenesis. +circulation_biomarker_diagnosis_down 35216319 hsa-mir-199b Rectal Neoplasms Altogether, our findings here demonstrate the functional relevance of miR-199b in this disease and its potential value as a novel circulating marker in LARC. +genetics_overexpression_promote 35216284 hsa-mir-99b Wilms Tumor In addition, five miRNAs (miR-99b-3p, miR-200a-3p, miR-200a, miR5p, miR-182) were commonly overexpressed in the exosomes from the WBI and PBI groups. +genetics_overexpression_promote 35216284 hsa-mir-200a Wilms Tumor In addition, five miRNAs (miR-99b-3p, miR-200a-3p, miR-200a, miR5p, miR-182) were commonly overexpressed in the exosomes from the WBI and PBI groups. +genetics_overexpression_promote 35216284 hsa-mir-182 Wilms Tumor In addition, five miRNAs (miR-99b-3p, miR-200a-3p, miR-200a, miR5p, miR-182) were commonly overexpressed in the exosomes from the WBI and PBI groups. +lncRNA target 35216222 hsa-mir-1246 Colonic Neoplasms To conclude, the present study revealed possible involvement of hsa-miR-1246 in early colorectal cancer development and regulation of tumor suppressors AXIN2 and CFTR. +circulation_biomarker_diagnosis_ns 35215330 hsa-mir-21 Pulmonary Disease, Chronic Obstructive Carbocysteine Modifies Circulating miR-21, IL-8, sRAGE, and fAGEs Levels in Mild Patients with Chronic Obstructive Pulmonary Disease (COPD) periodically experience acute exacerbation (AECOPD). +other 35215172 hsa-mir-1 Squamous Cell Carcinoma of Head and Neck 3p can distinguish cancer and control patients with high sensitivity. +other 35215172 hsa-mir-424 Squamous Cell Carcinoma of Head and Neck 3p can distinguish cancer and control patients with high sensitivity. +other 35215172 hsa-mir-345 Squamous Cell Carcinoma of Head and Neck 3p can distinguish cancer and control patients with high sensitivity. +other 35215154 hsa-mir-548 Squamous Cell Carcinoma of Head and Neck 3p expression increased in the OSCC group compared to the control group. +lncRNA target 35213977 hsa-mir-539 Choroidal Neovascularization iRGD-PLGA.NPs are promising approaches that reduced the viability of HRMECs, suggesting their therapeutic potential in the treatment of CNV. +lncRNA target 35213720 hsa-mir-205 Thyroid Cancer, Papillary mimics or GGCT inhibitors as potential therapeutics for PTC may have remarkable applications. +circulation_biomarker_diagnosis_ns 35213638 hsa-mir-146a Arthritis In conclusion, blocking circulating TNF-alpha impacted systemic inflammation-induced increased expression of miRNA-146a-5p and miRNA5p, which were associated with endothelial inflammation and impaired endothelial dependent vasorelaxation, respectively. +circulation_biomarker_diagnosis_ns 35213638 hsa-mir-146a Collagen Diseases In conclusion, blocking circulating TNF-alpha impacted systemic inflammation-induced increased expression of miRNA-146a-5p and miRNA5p, which were associated with endothelial inflammation and impaired endothelial dependent vasorelaxation, respectively. +circulation_biomarker_diagnosis_ns 35213638 hsa-mir-155 Arthritis In conclusion, blocking circulating TNF-alpha impacted systemic inflammation-induced increased expression of miRNA-146a-5p and miRNA5p, which were associated with endothelial inflammation and impaired endothelial dependent vasorelaxation, respectively. +circulation_biomarker_diagnosis_ns 35213638 hsa-mir-155 Collagen Diseases In conclusion, blocking circulating TNF-alpha impacted systemic inflammation-induced increased expression of miRNA-146a-5p and miRNA5p, which were associated with endothelial inflammation and impaired endothelial dependent vasorelaxation, respectively. +other 35213356 hsa-mir-218 Gastrointestinal Stromal Tumors Our findings indicate that a small number of miRNAs, with hsa-miR218-5p as a focus, may strongly affect the prognosis of GISTs. +lncRNA target 35213273 hsa-mir-143 Thyroid Cancer, Papillary Next, over-expression of miR-143 suppressed PTC cell growth as analyzed by MTT, clone formation, and Ki-67 immunofluorescence staining assays. +genetics_knock down_suppress 35213267 hsa-mir-7 Glioma In our experiments, the relative expression level of circRNA_0067934 and miR-7 in glioma tissue was detected by qRT-PCR, and specific gene knockdown was mediated by siRNA and miRNA-inhibitor. +exosome 35212942 hsa-mir-155 Human Herpesvirus 6 encephalitis Comparative analysis determined that some miRNAs (miR3p, miR-155) were exclusively expressed in the CSF exosomes of AED but not of FS patients, suggesting their potential application as novel diagnostic biomarkers for AED. +exosome 35212942 hsa-mir-381 Human Herpesvirus 6 encephalitis Comparative analysis determined that some miRNAs (miR3p, miR-155) were exclusively expressed in the CSF exosomes of AED but not of FS patients, suggesting their potential application as novel diagnostic biomarkers for AED. +circulation_biomarker_diagnosis_ns 35212793 hsa-mir-26a Esophageal Squamous Cell Carcinoma There were positive and negative strong correlations between miRNAs (miR-26a-5p and miR-205), target genes (LHCGR and CASP3) during different stages of CL, and steroid hormones in the serum. +circulation_biomarker_diagnosis_ns 35212793 hsa-mir-205 Esophageal Squamous Cell Carcinoma There were positive and negative strong correlations between miRNAs (miR-26a-5p and miR-205), target genes (LHCGR and CASP3) during different stages of CL, and steroid hormones in the serum. +circRNA target 35212614 hsa-mir-30 Prostatic Neoplasms In conclusion, our data confirmed that circMID1 might play a pro-cancer role in PCa, which promoted PCa progression through regulating the miR +other 35212610 hsa-mir-633 Atherosclerosis Taken together, hsa_circ_0008896 regulated the expression of CDC20B by sponging hsa-miR-633, and then enhanced proliferation, migration, and invasion of VSMCs to promote the progression of atherosclerosis. +lncRNA target 35212607 hsa-mir-449a Neuroblastoma In conclusion, Silencing of PEG10 could inhibit proliferation, migration, and invasion via the miR-449a/RPS2 axis in NB cells. +genetics_overexpression_promote 35212603 hsa-mir-124 Carcinoma, Hepatocellular Moreover, circHIPK3 overexpression reversed the inhibitory effect of miR-124 or miR-506 on HCC progression. +genetics_overexpression_promote 35212603 hsa-mir-506 Carcinoma, Hepatocellular Moreover, circHIPK3 overexpression reversed the inhibitory effect of miR-124 or miR-506 on HCC progression. +circRNA target 35212425 hsa-mir-214 Carcinoma, Non-Small-Cell Lung Together, results demonstrated that hsa_circ_0041268 acted as tumor promoter through novel hsa_circ_0041268/miR5p/ROCK1 axis, which highlighted its potential as NSCLC therapeutic agent. +transcription factor target 35211763 hsa-mir-200c Myocardial Reperfusion Injury Together, the results of the present study demonstrated that propofol postconditioning inhibited miR200c3p, upregulated AdipoR2 and activated the STAT3 signaling pathway, thus alleviating diabetic MI/RI and therefore highlighting its potential as a treatment of diabetic MI/RI. +genetics_knock down_promote 35211755 hsa-mir-141 Osteosarcoma In summary, the present study determined that circLRP6 knockdown inhibited the proliferation, migration and invasion of OS cells by regulating the miR1413p/HDAC4/HMGB1 axis. +lncRNA target 35211508 hsa-mir-214 Carcinoma, Non-Small-Cell Lung 3p/NCAPG axis in NSCLC may shed light on how NCAPG may act as a therapeutic target for NSCLC. +exosome 35211463 hsa-mir-218 Sciatic Neuropathy Furthermore, in a sciatic nerve injury model, exosomes delivering miR-218 combined with engineered scaffold facilitated the regeneration of injured sciatic nerves. +exosome 35211463 hsa-mir-218 Hypocapnia In the present study, we analyzed the functional differences of secreted exosomes in response to hypocapnia stimulation, and explored the application in combination with miR-218 to facilitate sciatic nerve regeneration. Our results indicated that the delivery system of engineered exosomes derived from ASCs remarkably loads upregulated miR-218 and promotes cellular activity in the recipient cells (PC12 cells), and hypocapnia stimuli-responsive exosomes exhibit strengthening properties. +other 35211156 hsa-mir-378a Cardiomegaly Our findings suggest that three mRNAs (Col12a1, Thbs1, and Tgfbr3), four miRNAs (miR-20a-5p, miR-27b-3p, miR3p, and miR-378a-3p), and four related circRNAs (circ_0002702, circ_0110609, circ_0013751, and circ_0047959) may play a key role in cardiac hypertrophy. +other 35211156 hsa-mir-27b Cardiomegaly Our findings suggest that three mRNAs (Col12a1, Thbs1, and Tgfbr3), four miRNAs (miR-20a-5p, miR-27b-3p, miR3p, and miR-378a-3p), and four related circRNAs (circ_0002702, circ_0110609, circ_0013751, and circ_0047959) may play a key role in cardiac hypertrophy. +other 35211156 hsa-mir-20a Cardiomegaly Our findings suggest that three mRNAs (Col12a1, Thbs1, and Tgfbr3), four miRNAs (miR-20a-5p, miR-27b-3p, miR3p, and miR-378a-3p), and four related circRNAs (circ_0002702, circ_0110609, circ_0013751, and circ_0047959) may play a key role in cardiac hypertrophy. +other 35211156 hsa-mir-342 Cardiomegaly Our findings suggest that three mRNAs (Col12a1, Thbs1, and Tgfbr3), four miRNAs (miR-20a-5p, miR-27b-3p, miR3p, and miR-378a-3p), and four related circRNAs (circ_0002702, circ_0110609, circ_0013751, and circ_0047959) may play a key role in cardiac hypertrophy. +target gene 35211152 hsa-mir-103a Prostatic Neoplasms Upregulation of miR-103a-3p and interference with TRIM66 can inhibit DTX resistance and glycolysis of PCa cells. +other 35211114 hsa-mir-126 Otofaciocervical Syndrome Hsa-miR5p is potentially a very promising diagnostic biomarker for CE. +circulation_biomarker_diagnosis_ns 35210895 hsa-mir-126 Leukemia, Myeloid, Acute 5p was measured in the plasma of 43 adult AML patients and 35 age- and sex-matched controls by quantitative reverse transcriptase PCR. +circulation_biomarker_diagnosis_ns 35210895 hsa-mir-423 Leukemia, Myeloid, Acute 5p was measured in the plasma of 43 adult AML patients and 35 age- and sex-matched controls by quantitative reverse transcriptase PCR. +other 35210837 hsa-mir-3199 Colonic Neoplasms This research intended to evaluate the prognostic values of LINC01006 and miR-3199 for colon cancer and their effects on cell physiology. High LINC01006 level (HR = 4.048, 95%: 1.502-10.911, P = 0.006) or low miR-3199 level (HR = 3.421, 95% CI: 1.254-9.330, P = 0.016) was outstanding for predicting poor prognosis in patients with colon cancer. +other 35210471 hsa-mir-10b Huntington Disease We found that hsa-mir-10b-5p was edited to have an additional cytosine at 5'-end in HD-PC, and the edited hsa-mir-10b repressed GTPBP10 that was often downregulated in HD. +exosome 35210436 hsa-mir-19b Squamous Cell Carcinoma of Head and Neck The corresponding data demonstrated that the M1 exosomal lncRNA HOTTIP suppresses HNSCC progression by upregulating the TLR5/NF-kappaB signaling pathway through competitively sponging miR-19a-3p and miR-19b-3p. +transcription factor target 35210412 hsa-mir-509 Ovarian Neoplasms In conclusion, our results suggested that SF3B4, negatively regulated by miR3p, promoted OC progression through effective splicing of RAD52. +transcription factor target 35210391 hsa-mir-150 Neuralgia In conclusion, we demonstrated an essential function of METTL3-regulated N6-methyladenosine during NP progression via modulating primiR-150 maturation. Therefore, the METTL3/miR-150/BDNF pathway may be a promising therapeutic target for NP patients. +other 35209928 hsa-mir-326 Pneumonia, Mycoplasma In this study, placental tissues taken from healthy donors and PE patients were used to evaluate the miR-326 expression; CCK8 and colony formation assays were used to confirm the effect of miR-326 on cell proliferation; transwell assay was used to demonstrate the effect of miR-326 on cell invasion capability; western blot was used to investigate the underlying mechanism; and luciferase assay was used to detect the effect of miR-326 on YAP/TAZ-mediated transcription activity. It was revealed the miR-326 expression was higher in placentas from PE patients than from healthy donors. +other 35208504 hsa-mir-192 Celiac Disease 5p, miR-449a and miR-638) in adult patients with CD. +other 35208504 hsa-mir-194 Celiac Disease Among the miRNAs, the closest to a statistically significant value was miR5p when the newly diagnosed group versus control (p = 0.0510) and GFD group versus control (p = 0.0671) were compared. +other 35208504 hsa-mir-638 Celiac Disease 5p, miR-449a and miR-638) in adult patients with CD. +other 35208504 hsa-mir-449a Celiac Disease 5p, miR-449a and miR-638) in adult patients with CD. +circulation_biomarker_diagnosis_up 35207812 hsa-mir-155 COVID-19 We found that mild COVID-19 patients had 2.5-fold less circulating miR-155 than healthy people, and patients with a severe COVID-19 disease had 5-fold less circulating miR-155 than healthy people. +other 35207076 hsa-mir-6727 Wound Healing Homo Sapiens (Hsa)-microRNA (miR)-6727-5p Contributes to the Impact of High-Density Lipoproteins on Fibroblast Wound Healing In Vitro. +transcription factor target 35205813 hsa-mir-1244 Lymphoma, Large B-Cell, Diffuse In the DLBCL cell line U-2932 the transfection with miR-1244 and miR-193b-5p, but not miR-1231, blocked the effect of CHOP on cell viability. +transcription factor target 35205813 hsa-mir-1231 Lymphoma, Large B-Cell, Diffuse In the DLBCL cell line U-2932 the transfection with miR-1244 and miR-193b-5p, but not miR-1231, blocked the effect of CHOP on cell viability. +transcription factor target 35205813 hsa-mir-193b Lymphoma, Large B-Cell, Diffuse In the DLBCL cell line U-2932 the transfection with miR-1244 and miR-193b-5p, but not miR-1231, blocked the effect of CHOP on cell viability. +other 35205713 hsa-mir-143 Urinary Bladder Neoplasms Long Noncoding RNA LINC02470 Sponges MicroRNA-143-3p and Enhances SMAD3-Mediated Epithelial-to-Mesenchymal Transition to Promote the Aggressive Properties of Bladder Cancer. +other 35205710 hsa-mir-101 Lung Neoplasms 3p is associated with tumorigenesis. +other 35205648 hsa-mir-195 Colorectal Neoplasms We have identified three miRNA combinations (hsa-miR-195 hsa-miR-210 hsa-miR-503; hsa-miR-210 hsa-miR-375 hsa-miR-503 and hsa-miR-210 hsa-miR5p hsa-miR-503) as unexpectedly good predictors to determine adrenocortical malignancy with sensitivity and specificity both of over 90%. +other 35205648 hsa-mir-375 Adrenocortical Carcinoma We have identified three miRNA combinations (hsa-miR-195 hsa-miR-210 hsa-miR-503; hsa-miR-210 hsa-miR-375 hsa-miR-503 and hsa-miR-210 hsa-miR5p hsa-miR-503) as unexpectedly good predictors to determine adrenocortical malignancy with sensitivity and specificity both of over 90%. +other 35205648 hsa-mir-210 Colorectal Neoplasms We have identified three miRNA combinations (hsa-miR-195 hsa-miR-210 hsa-miR-503; hsa-miR-210 hsa-miR-375 hsa-miR-503 and hsa-miR-210 hsa-miR5p hsa-miR-503) as unexpectedly good predictors to determine adrenocortical malignancy with sensitivity and specificity both of over 90%. +other 35205648 hsa-mir-483 Colorectal Neoplasms We have identified three miRNA combinations (hsa-miR-195 hsa-miR-210 hsa-miR-503; hsa-miR-210 hsa-miR-375 hsa-miR-503 and hsa-miR-210 hsa-miR5p hsa-miR-503) as unexpectedly good predictors to determine adrenocortical malignancy with sensitivity and specificity both of over 90%. +other 35205648 hsa-mir-195 Adrenocortical Carcinoma We have identified three miRNA combinations (hsa-miR-195 hsa-miR-210 hsa-miR-503; hsa-miR-210 hsa-miR-375 hsa-miR-503 and hsa-miR-210 hsa-miR5p hsa-miR-503) as unexpectedly good predictors to determine adrenocortical malignancy with sensitivity and specificity both of over 90%. +other 35205648 hsa-mir-503 Colorectal Neoplasms We have identified three miRNA combinations (hsa-miR-195 hsa-miR-210 hsa-miR-503; hsa-miR-210 hsa-miR-375 hsa-miR-503 and hsa-miR-210 hsa-miR5p hsa-miR-503) as unexpectedly good predictors to determine adrenocortical malignancy with sensitivity and specificity both of over 90%. +other 35205648 hsa-mir-503 Adrenocortical Carcinoma We have identified three miRNA combinations (hsa-miR-195 hsa-miR-210 hsa-miR-503; hsa-miR-210 hsa-miR-375 hsa-miR-503 and hsa-miR-210 hsa-miR5p hsa-miR-503) as unexpectedly good predictors to determine adrenocortical malignancy with sensitivity and specificity both of over 90%. +other 35205648 hsa-mir-210 Adrenocortical Carcinoma We have identified three miRNA combinations (hsa-miR-195 hsa-miR-210 hsa-miR-503; hsa-miR-210 hsa-miR-375 hsa-miR-503 and hsa-miR-210 hsa-miR5p hsa-miR-503) as unexpectedly good predictors to determine adrenocortical malignancy with sensitivity and specificity both of over 90%. +other 35205648 hsa-mir-483 Adrenocortical Carcinoma We have identified three miRNA combinations (hsa-miR-195 hsa-miR-210 hsa-miR-503; hsa-miR-210 hsa-miR-375 hsa-miR-503 and hsa-miR-210 hsa-miR5p hsa-miR-503) as unexpectedly good predictors to determine adrenocortical malignancy with sensitivity and specificity both of over 90%. +other 35205648 hsa-mir-375 Colorectal Neoplasms We have identified three miRNA combinations (hsa-miR-195 hsa-miR-210 hsa-miR-503; hsa-miR-210 hsa-miR-375 hsa-miR-503 and hsa-miR-210 hsa-miR5p hsa-miR-503) as unexpectedly good predictors to determine adrenocortical malignancy with sensitivity and specificity both of over 90%. +other 35205607 hsa-mir-126 Carcinoma, Renal Cell The hsa-miR3p/hsa-miR-200b-3p panel identified the most common RCC subtype (clear cell, ccRCC) with 74.78% sensitivity. +other 35205607 hsa-mir-200b Carcinoma, Renal Cell The hsa-miR3p/hsa-miR-200b-3p panel identified the most common RCC subtype (clear cell, ccRCC) with 74.78% sensitivity. +lncRNA target 35205327 hsa-mir-874 Carcinoma, Hepatocellular The study goal was to examine VEGFA (vascular endothelial growth factor A) expression in hepatocellular carcinoma (HCC) cell lines upon transfection miR-612, miR-637, or miR-874. Methods: MiR-612 mimics, miR-637 mimics, or miR-874 inhibitors were transfected using Lipofectamine RNAiMax in both HCC cell lines, HepG2 and HuH-7. +lncRNA target 35205327 hsa-mir-637 Carcinoma, Hepatocellular The study goal was to examine VEGFA (vascular endothelial growth factor A) expression in hepatocellular carcinoma (HCC) cell lines upon transfection miR-612, miR-637, or miR-874. Methods: MiR-612 mimics, miR-637 mimics, or miR-874 inhibitors were transfected using Lipofectamine RNAiMax in both HCC cell lines, HepG2 and HuH-7. +other 35205276 hsa-mir-101 Frailty 5p were found to be downregulated in the frail vs. +other 35205276 hsa-mir-142 Frailty 5p were found to be downregulated in the frail vs. +other 35205216 hsa-mir-142 Hashimoto Disease 3p were associated with higher levels of thyroid antibodies, suggesting their contribution to the pathogenesis of HT. +other 35205216 hsa-mir-22 Hashimoto Disease 3p were associated with higher levels of thyroid antibodies, suggesting their contribution to the pathogenesis of HT. +other 35204817 hsa-mir-199a Leg Ulcer Furthermore, in silico analyses indicated interactions of miR-199a-5p with HIF1A, Ets-1, and TGFB2 genes, which are associated with vasculopathy and reduced NO. +circulation_biomarker_diagnosis_ns 35204817 hsa-mir-126 Leg Ulcer The circulating miR-126 may play a protective role in SLU. +other 35204816 hsa-mir-193b Osteoarthritis Moreover, when both conditions were analyzed together, miR3p resulted the most stable RGs, allowing for a sharper comparison of EVs content, further validated on the OA-related miRNA-193b-5p. +other 35204816 hsa-mir-24 Osteoarthritis Moreover, when both conditions were analyzed together, miR3p resulted the most stable RGs, allowing for a sharper comparison of EVs content, further validated on the OA-related miRNA-193b-5p. +other 35204460 hsa-mir-374c Tuberculosis Anti-TB treatment restored the levels of miR-199b-3p, miR-199a-3p, miR5p, and miR-374c-5p to HC levels. +other 35204460 hsa-mir-199a Tuberculosis Among them, miR-199a-3p and miR3p can differentiate between ATB and LTBI. +other 35204460 hsa-mir-199b Tuberculosis Anti-TB treatment restored the levels of miR-199b-3p, miR-199a-3p, miR5p, and miR-374c-5p to HC levels. +other 35204460 hsa-mir-16 Tuberculosis Anti-TB treatment restored the levels of miR-199b-3p, miR-199a-3p, miR5p, and miR-374c-5p to HC levels. +other 35204460 hsa-mir-6886 Tuberculosis Among them, miR-199a-3p and miR3p can differentiate between ATB and LTBI. +circulation_biomarker_diagnosis_ns 35203931 hsa-mir-206 Schizophrenia were quantified in the blood of 48 healthy controls and 32 SZ patients before and after 12 weeks of treatment. +circulation_biomarker_diagnosis_ns 35203931 hsa-mir-132 Schizophrenia were quantified in the blood of 48 healthy controls and 32 SZ patients before and after 12 weeks of treatment. +circulation_biomarker_diagnosis_ns 35203931 hsa-mir-124 Schizophrenia were quantified in the blood of 48 healthy controls and 32 SZ patients before and after 12 weeks of treatment. +other 35203692 hsa-mir-29a Diabetes, Gestational The change over time only differed for miR-29a-3p when comparing women with GDM with those remaining NGT (p = 0.044). +other 35203467 hsa-mir-20a Growth Disorders 3p) can predict the later occurrence of PE in 48.48% of pregnancies at 10.0% FPR in early stages of gestation. +other 35203467 hsa-mir-20a Pre-Eclampsia 3p) can predict the later occurrence of PE in 48.48% of pregnancies at 10.0% FPR in early stages of gestation. +other 35203467 hsa-mir-20a Hypertension, Pregnancy-Induced 3p) can predict the later occurrence of PE in 48.48% of pregnancies at 10.0% FPR in early stages of gestation. +other 35203467 hsa-mir-20a Cardiovascular Diseases 3p) can predict the later occurrence of PE in 48.48% of pregnancies at 10.0% FPR in early stages of gestation. +other 35203467 hsa-mir-146a Pre-Eclampsia 3p) can predict the later occurrence of PE in 48.48% of pregnancies at 10.0% FPR in early stages of gestation. +other 35203467 hsa-mir-146a Hypertension, Pregnancy-Induced 3p) can predict the later occurrence of PE in 48.48% of pregnancies at 10.0% FPR in early stages of gestation. +other 35203467 hsa-mir-146a Cardiovascular Diseases 3p) can predict the later occurrence of PE in 48.48% of pregnancies at 10.0% FPR in early stages of gestation. +other 35203467 hsa-mir-146a Growth Disorders 3p) can predict the later occurrence of PE in 48.48% of pregnancies at 10.0% FPR in early stages of gestation. +other 35203467 hsa-mir-181a Cardiovascular Diseases Upregulation of miR-181a-5p was detected in normotensive women subsequently developing GH (22.89% at 10.0% FPR) or PE (40.91% at 10.0% FPR). +other 35203467 hsa-mir-181a Hypertension, Pregnancy-Induced Upregulation of miR-181a-5p was detected in normotensive women subsequently developing GH (22.89% at 10.0% FPR) or PE (40.91% at 10.0% FPR). +other 35203467 hsa-mir-181a Pre-Eclampsia Upregulation of miR-181a-5p was detected in normotensive women subsequently developing GH (22.89% at 10.0% FPR) or PE (40.91% at 10.0% FPR). +other 35203467 hsa-mir-181a Growth Disorders Upregulation of miR-181a-5p was detected in normotensive women subsequently developing GH (22.89% at 10.0% FPR) or PE (40.91% at 10.0% FPR). +circulation_biomarker_prognosis_ns 35203396 hsa-mir-8074 Multiple Myeloma Circulating Serum MiRNA-8074 as a Novel Prognostic Biomarker for Multiple MiRNA-8074 is a molecule with the potential to regulate the expression of key genes related to the pathogenesis of multiple myeloma (MM), i.e., TP53, MYC, MAPK1, and KIAA. +other 35203389 hsa-mir-150 Myasthenia Gravis Levels of miR-30e-5p and miR5p significantly differed between MG patients and healthy controls; however, no difference was seen compared with patients affected by other neuroimmune diseases. +genetics_overexpression_suppress 35203290 hsa-mir-429 Carcinoma, Transitional Cell METHODS: Quantitative RT-PCR, immunoblotting assay and tube formation examined the effect of hsa-miR-429 mimic or/and inhibitor on VEGFA expression and angiogenesis in CEBPD-overexpressing UC-derived cells. +other 35203245 hsa-mir-21 Nephritis, Hereditary These results support the addition of anti-miR-21 to the current standard of care (ACEi) in ongoing clinical trials in patients with Alport syndrome. +circRNA target 35203042 hsa-mir-1 Arthritis Additionally, consecutive rescue experiments indicated that the inhibitory impacts of TPL on RA-FLSs were dependent on the circ0003353/miR +circRNA target 35203042 hsa-mir-1 Arthritis, Rheumatoid Additionally, consecutive rescue experiments indicated that the inhibitory impacts of TPL on RA-FLSs were dependent on the circ0003353/miR +lncRNA target 35202986 hsa-mir-149 Osteoarthritis CONCLUSION: These finding demonstrated that SOX4-activated MCM3AP-AS1 aggravated OA progression by modulating autophagy and ECM degradation via targeting miR5p/Notch1 axis. +other 35202801 hsa-mir-1 Bronchiolitis Obliterans Syndrome Among the core miRNAs, miR3p and miR-335 were differentially expressed in IRI rats. +other 35202801 hsa-mir-335 Bronchiolitis Obliterans Syndrome Among the core miRNAs, miR3p and miR-335 were differentially expressed in IRI rats. +lncRNA target 35202706 hsa-mir-20a Diabetic Retinopathy In conclusion, MALAT1 inhibits HIF-1alpha expression and MRMECs angiogenesis in DR through spongy miR-320a. +genetics_GWAS 35202641 hsa-mir-454 Carcinoma, Non-Small-Cell Lung Interestingly, SNP rs1127317 locating in the ADAR 3'-untranslated region regulates gene expression in an allele-specific manner via modulating binding of miR5p in cells. +circRNA target 35202487 hsa-mir-548b Glioblastoma In conclusion, the present study demonstrated that a circBFAR/miR-548b/FoxM1 axis regulates the development of GBM and highlights potentially novel therapeutic targets for the treatment of GBM. +lncRNA target 35202090 hsa-mir-410 Immune System Diseases This research provides novel insights into immune dysfunction contributing to infection outcomes and suggests the use of the antagomiRs/inhibitors of miR-294 and miR-410 as new therapeutic strategies to modulate inflammation and to decrease parasitism. +lncRNA target 35202090 hsa-mir-294 Immune System Diseases This research provides novel insights into immune dysfunction contributing to infection outcomes and suggests the use of the antagomiRs/inhibitors of miR-294 and miR-410 as new therapeutic strategies to modulate inflammation and to decrease parasitism. +other 35202085 hsa-mir-183 Prostatic Neoplasms Overall, cell adhesion was uncovered as a major pathway controlled by miR-183 in prostate cancer, and ITGB1 was identified as a relevant mediator of this effect. +other 35202022 hsa-mir-370 Pre-Eclampsia One of the differentially expressed miRNAs, hsa-miR3p, which was upregulated in the preeclampsia group, was shown to bind to the 3' untranslated region of C-X-C motif chemokine 12, a chemokine that plays important role during preeclampsia process. +circulation_biomarker_diagnosis_up 35202004 hsa-mir-451a Anaphylaxis Blood samples were taken upon emergency room arrival and 1 month later.ResultsNext-generation sequencing of 18 samples (6 patients with anaphylaxis in both acute and nonacute condition, for 12 total samples, and 6 healthy controls) identified hsa-miR-451a to be elevated during anaphylaxis, which was verified by quantitative real-time PCR in the remaining cohort. We identified tryptase, 9alpha,11beta-PGF2, apolipoprotein A1, and hsa-miR-451a as serological biomarkers of anaphylaxis. +other 35202001 hsa-mir-223 Atherosclerosis 3p. +genetics_overexpression_promote 35201653 hsa-mir-186 Squamous Cell Carcinoma of Head and Neck The overexpression of miR +other 35201491 hsa-mir-1 Carcinoma, Hepatocellular 3p/DUXAP8 ceRNA network axis with immune cell infiltration provides further information on the mechanism of HCC development. +other 35201491 hsa-mir-29 Carcinoma, Hepatocellular 3p/DUXAP8 ceRNA network axis with immune cell infiltration provides further information on the mechanism of HCC development. +other 35201491 hsa-mir-4435-2 Carcinoma, Hepatocellular 3p/DUXAP8 ceRNA network axis with immune cell infiltration provides further information on the mechanism of HCC development. +exosome 35201481 hsa-mir-20a Ovarian Neoplasms Extracellular vesicle-derived miR-320a targets ZC3H12B to inhibit tumorigenesis, invasion, and angiogenesis in ovarian cancer. +target gene 35201478 hsa-mir-26a Pancreatic Neoplasms microRNA-26a represses pancreatic cancer cell malignant behaviors by targeting E2F7. +target gene 35201476 hsa-mir-376a Osteosarcoma Silencing long intergenic non-protein coding RNA 00987 inhibits proliferation, migration, and invasion of osteosarcoma cells by sponging miR-376a-5p to regulate FNBP1 expression. +transcription factor target 35201360 hsa-mir-199a Lung Diseases After ozone exposure, miR-199a-3p, but not precursor miR-199a-3p, was increased in lung macrophages, indicating that it is derived from MV-mediated delivery. Furthermore, lung macrophage mRNA expression of IL-1beta was upregulated after administration of MVs containing miR-199a-3p mimic but downregulated by miR-199a-3p inhibitor. +other 35200555 hsa-mir-127 Breast Neoplasms Upregulation of miR-127 correlated with pCR in triple-negative breast cancer (TNBC). +genetics_overexpression_promote 35200157 hsa-mir-942 Urinary Bladder Neoplasms Rescue experiments showed that suppression of miR-942 or BARX2 overexpression could significantly abrogate the promoting effects of circSHPRH silencing on BCa cell proliferation and invasion. +genetics_knock down_promote 35200111 hsa-mir-1298 Stomach Neoplasms 5p interference or ZBED3 overexpression showed the opposite trend. +exosome 35200105 hsa-mir-15a Wilms Tumor Moreover, tumor formation tests further assessed the role of exosomal miR-15a-5p in WT. +exosome 35200104 hsa-mir-23a Cholangiocarcinoma Exosomal microRNA-23a-3p contributes to the progression of cholangiocarcinoma by interaction with Dynamin3. +lncRNA target 35200103 hsa-mir-495 Fibrosis In summary, NORAD silencing inhibited hepatic fibrosis by suppressing HSC activation via the miR +other 35200096 hsa-mir-1269b Hemangioma The expression of BRCAT54 and miR-1269b in hemangioma samples, as well as hemangioma-derived endothelial cells (HDECs) and human umbilical vein endothelial cells (HUVECs) were detected by RT-qPCR. +genetics_overexpression_suppress 35199943 hsa-mir-421 Sepsis Our data demonstrated that in the LPS-induced sepsis model of myocardial cells, SNHG16 overexpression downregulated the expression level of miR-421, which sustained the expression of SOCS5 to alleviate the adverse effects of LPS, such as apoptosis, pro-inflammatory cytokines, and oxidative stress. Targeting miR-421 or modulating lncRNA SNHG16 level may be leveraged as a beneficial strategy against sepsis-induced cellular damage in cardiomyocytes. +genetics_overexpression_suppress 35199943 hsa-mir-421 Cardiomyopathies Our data demonstrated that in the LPS-induced sepsis model of myocardial cells, SNHG16 overexpression downregulated the expression level of miR-421, which sustained the expression of SOCS5 to alleviate the adverse effects of LPS, such as apoptosis, pro-inflammatory cytokines, and oxidative stress. Targeting miR-421 or modulating lncRNA SNHG16 level may be leveraged as a beneficial strategy against sepsis-induced cellular damage in cardiomyocytes. +genetics_knock down_promote 35199939 hsa-mir-627 Thyroid Cancer, Papillary Overexpression of miR-627 in PTC inhibited the proliferation, migration, and invasion by down-regulating the expression of TRIM44. +lncRNA target 35199935 hsa-mir-195 Pancreatic Carcinoma In summary, CERS6-AS1 facilitates PC cell proliferation while inhibiting PC cell apoptosis by upregulating WIPI2 via miR +other 35199873 hsa-mir-190a Carcinoma, Hepatocellular CONCLUSION: Our results suggested that circ_0008194 may act as a sponge to adsorb miR-190a, thereby promoting the expression of AHNAK and promoting the metastasis of liver cancer tumors. +exosome 35199612 hsa-mir-618 Liver Cirrhosis These findings indicated that treatment of exosomal miR-618 derived from MSCs might serve as a new strategy for HF. +circRNA target 35199365 hsa-mir-6165 Carcinoma, Hepatocellular Mechanistically, we revealed that circ_0001459 could sponge miR-6165 and induce the upregulation of its downstream target IGF1R, thus significantly promoting the progression of HCC. +circulation_biomarker_diagnosis_ns 35199358 hsa-mir-34a Cardiotoxicity This association between plasma and heart may suggest miR-34a-5p as a potential early circulating marker of early-onset DOX cardiotoxicity. In addition, higher expression of miR-34a-5p (FDR < 0.1) in plasma and heart compared with SAL-treated controls 24 weeks after 24 mg/kg total cumulative DOX dose, when cardiac function was altered in our recently established delayed-onset cardiotoxicity model, indicated its potential as an early biomarker of delayed-onset cardiotoxicity. +target gene 35198876 hsa-mir-1273g Colorectal Neoplasms p73-regulated FER1L4 lncRNA sponges the oncogenic potential of miR-1273g-3p and aids in the suppression of colorectal cancer metastasis. +epigenetics 35198364 hsa-mir-451a Osteosarcoma MiR-451a promotes cell growth, migration and EMT in osteosarcoma by regulating YTHDC1-mediated m6A methylation to activate the AKT/mTOR signaling pathway. +genetics_overexpression_promote 35198058 hsa-mir-15a Liver Injury Conclusions: Galpha(12) overexpression by ER stress facilitates hepatocyte ferroptosis through ROCK1-mediated dysregulation of ALOX12, and miR-15a, supporting the concept that inhibition of Galpha(12) overexpression and/or ROCK1 axis may constitute a promising strategy for acute liver injury. +genetics_overexpression_promote 35198024 hsa-mir-526b Glioma Overexpression of miR-526b-3p within ADR-resistant glioma cells obtained similar results, which suggested miR-526b-3p suppressed glioma cell resistance to ADR. +other 35197661 hsa-mir-21 Prostatic Neoplasms, Castration-Resistant CONCLUSION: There is a significant difference in the expression values of miRNA-21 between BPH with CRPC and Prostate cancer and CRPC, therefore, miRNA-21 cut-off point is potential to differentiate the diagnosis. +other 35197055 hsa-mir-199a Carcinoma, Hepatocellular RESULTS: A prognostic model of 5 VI-related miRNAs (hsa-miR3p, hsa-miR-148a-3p, hsa-miR-15a-5p, hsa-miR-30a-5p, hsa-miR-199a-5p) was constructed. +other 35197055 hsa-mir-126 Carcinoma, Hepatocellular RESULTS: A prognostic model of 5 VI-related miRNAs (hsa-miR3p, hsa-miR-148a-3p, hsa-miR-15a-5p, hsa-miR-30a-5p, hsa-miR-199a-5p) was constructed. +other 35197055 hsa-mir-15a Carcinoma, Hepatocellular RESULTS: A prognostic model of 5 VI-related miRNAs (hsa-miR3p, hsa-miR-148a-3p, hsa-miR-15a-5p, hsa-miR-30a-5p, hsa-miR-199a-5p) was constructed. +other 35197055 hsa-mir-148a Carcinoma, Hepatocellular RESULTS: A prognostic model of 5 VI-related miRNAs (hsa-miR3p, hsa-miR-148a-3p, hsa-miR-15a-5p, hsa-miR-30a-5p, hsa-miR-199a-5p) was constructed. +other 35196982 hsa-mir-424 Neurotoxicity Syndromes miR-424 has the potential to regulate the neurotoxicity caused by isoflurane anesthesia, and it has a complementary sequence with the 3'UTR region of TLR4. Thus, our study aims to explore whether sevoflurane directly causes neurotoxicity, the effects of miR-424 on sevoflurane induced apoptosis and inflammation, and the underlying mechanism. +genetics_knock down_promote 35196944 hsa-mir-532 Ovarian Neoplasms 3p, and circ_0025033 knockdown blocked the malignant activities of PTX-resistant OC cells by enriching miR +lncRNA target 35196925 hsa-mir-189 Osteoarthritis CONCLUSION: Circ_0110251 protected chondrocytes from IL-1beta-induced apoptosis and ECM degradation in OA via sponging miR3p and elevating SPRY1. +target gene 35196780 hsa-mir-24 Leukemia, Myeloid, Acute lncRNA C9ORF139 targeting miR-24-3P/TAOK1 in regulating the proliferation of acute myeloid leukemia cells +genetics_overexpression_promote 35196590 hsa-mir-214 Intervertebral Disc Degeneration Collectively, these data suggest that ADIRF-AS1 overexpression could mitigate IDD by binding to miR +circulation_biomarker_diagnosis_up 35196550 hsa-mir-155 Carcinoma, Hepatocellular METHODS: Exosomal miR-155 quantity was analyzed by sampling serum exosomes of patients with hepatocellular carcinoma and normal subjects. +lncRNA target 35196388 hsa-mir-206 chikungunya METHODS: We evaluated the vaccine potential of a recently described LAV, skeletal muscle-restricted virus (SKE), that exhibits diminished replication in skeletal muscle due to insertion of target sequences for skeletal muscle-specific miR-206. +genetics_overexpression_promote 35196205 hsa-mir-147a Nasopharyngeal Carcinoma The promotion effect of circSETD3 overexpression on NPC proliferation and DDP resistance and inhibition effect on apoptosis was reversed by elevated miR-147a. In conclusion, the results of this study confirm that circSETD3 promotes NPC proliferation and DDP resistance by regulating miR-147a, and circSETD3/miR-147a axis may serve as a potential therapeutic target for NPC in the future. +other 35196197 hsa-mir-376a Carcinoma, Non-Small-Cell Lung These results suggest that circ-UBE2D2 promotes the proliferation, migration and invasion but restrains apoptosis of lung cancer cells by regulating miR-376a-3p/EIF4G2 axis. +genetics_knock down_promote 35196196 hsa-mir-4461 Gallbladder Neoplasms Special EGFR siRNA or AKT overexpression virus abolishes the discrepancy of self-renewal, tumorigenesis, growth, and metastasis between miR-4461 overexpression GBC cells and their control cells. +circRNA target 35196193 hsa-mir-940 Carcinoma, Non-Small-Cell Lung In all, circ_0020123 acted as an oncogene to promote the tumorigenesis of NSCLC via miR-940/KIAA1522 axis, suggesting a potential therapeutic target for NSCLC treatment. +genetics_overexpression_promote 35196185 hsa-mir-646 Adenocarcinoma of Lung MiR-3646 overexpression stimulated the proliferation and adhesion of LUAD cells but inhibite d apoptosis, whereas a miR-3646 inhibitor produced the opposite results. +lncRNA target 35195809 hsa-mir-146a Plaque, Atherosclerotic However, the effect of miR-146a on the stability of atherosclerotic plaque remains to be elucidated. CONCLUSIONS: We display for the first time that miR-146a inhibits the formation of foam cells, RAW264.7 macrophage apoptosis and pro-inflammatory reaction through negative regulation of IRAK1 and TRAF6 expression, thereby enhancing the stability of atherosclerotic plaques. +other 35195734 hsa-mir-153 Hyperphosphatemia 3p decreased calcium deposition in both uremia rats treated with HP-EMPs or not. +other 35194770 hsa-mir-25 Inflammation CONCLUSION: MiR-25/miR-92b family plays a major role in beta-cell failure occurring under inflammation and diabetes states. +other 35194770 hsa-mir-92b Diabetes Mellitus This study reported here specifically assessed the association between miR-25/miR-92b family and beta-cell failure in diabetes. CONCLUSION: MiR-25/miR-92b family plays a major role in beta-cell failure occurring under inflammation and diabetes states. +other 35194770 hsa-mir-25 Diabetes Mellitus This study reported here specifically assessed the association between miR-25/miR-92b family and beta-cell failure in diabetes. CONCLUSION: MiR-25/miR-92b family plays a major role in beta-cell failure occurring under inflammation and diabetes states. +other 35194770 hsa-mir-92b Inflammation CONCLUSION: MiR-25/miR-92b family plays a major role in beta-cell failure occurring under inflammation and diabetes states. +other 35194759 hsa-mir-192 Neonatal hemochromatosis Placental miR5p expression was lower among NHB people and was positively associated with neonatal adiposity, suggesting it may be sensitive to structural racism with potential impacts on fetal growth. +other 35194735 hsa-mir-27 Myocardial Infarction, Acute 3p was downregulated after AMI. +transcription factor target 35194732 hsa-mir-512 Melanoma 3p by suppressing growth of melanoma both in vitro and in vivo targeting the p27 Kip1 axis. +genetics_overexpression_promote 35194440 hsa-mir-142 Glioblastoma The miR-142 was overexpressed in U-87 glioblastoma cells via lentiviral transduction, and the way it influences proliferation and migration of cells was investigated through MTT assay and wound healing assay. The miR-142 significantly suppressed cell proliferation and migration and induced apoptosis and cell-cycle arrest in U-87 glioblastoma cells. +target gene 35194440 hsa-mir-424 Glioblastoma Overall, miR-424 acts as tumor suppressor miRNA in glioblastoma cells. +circulation_biomarker_diagnosis_up 35194091 hsa-mir-4645 Cholangitis, Sclerosing, Primary One of the newly identified miRNAs, miR3p, was significantly up-regulated fourfold in PSC-derived EVs compared to circulating EVs isolated from healthy controls. +other 35193668 hsa-mir-147a Diabetic Nephropathies CONCLUSION: In total, our research pointed out that lncRNA HOTAIR could mediate miR-147a/WNT2B axis to promote DN progression. +lncRNA target 35193602 hsa-mir-146a Esophageal Neoplasms Moreover, our findings revealed that HDAC4 conferred radioresistance of EC by downregulating microRNA-146a (miR-146a). Silencing of HDAC4 radiosensitized EC cells both in vitro and in vivo via the miR-146a/IRAK1 axis. +lncRNA target 35193567 hsa-mir-561 Pancreatic Carcinoma 5p/LDHA axis, suggesting LINC01128 may be a new prognostic marker and therapeutic target in PC. +exosome 35193488 hsa-mir-524 Liver Neoplasms CONCLUSIONS: CAFs-derived exosomal TUG1 promoted migration, invasion, and glycolysis in HCC cells via the miR +genetics_overexpression_promote 35193469 hsa-mir-545 Retinoblastoma 3p treatment phenocopied the effect of AFAP1-AS1 overexpression and promoted RB cell growth in vivo. +epigenetics 35193115 hsa-mir-34a Colonic Neoplasms BACKGROUND: LncRNA potassium voltage-gated channel subfamily Q member 1 opposite strand/antisense transcript 1 (KCNQ1OT1) has been reported to promote resistance to chemotherapy in colon cancer by inhibiting the expression of miR-34a. RESULTS: Carrier of allele 10 and methylated promoter in KCNQ1OT1 was associated with decreased KCNQ1OT1/ATG4B expression, increased miR-34a expression and enhanced apoptosis in colon cancer tissue samples. +transcription factor target 35192930 hsa-mir-1298 Stomach Neoplasms 5p, through which miR +genetics_overexpression_promote 35192807 hsa-mir-205 von Willebrand Diseases In summary, our findings provide experimental evidence that overexpression of vWF in breast cancer cells down-regulates the expression of miR5p and up-regulates the expression of VEGF-A through the PI3K/Akt signaling pathway, thereby promoting tumor angiogenesis and metastasis. +genetics_overexpression_promote 35192807 hsa-mir-205 Breast Neoplasms In summary, our findings provide experimental evidence that overexpression of vWF in breast cancer cells down-regulates the expression of miR5p and up-regulates the expression of VEGF-A through the PI3K/Akt signaling pathway, thereby promoting tumor angiogenesis and metastasis. +other 35192776 hsa-let-7 Fanconi Anemia Our data show that the Fanconi anemia pathway and the H19/let-7/LIN28B axis may be involved in gamma- to beta-globin gene switching. +transcription factor target 35192632 hsa-mir-19b non-alcoholic steatohepatitis Therefore, ipragliflozin can improve NASH development likely through the antioxidative stress pathway and by regulating miR-19b-3p. +transcription factor target 35192356 hsa-mir-371b Colonic Neoplasms Altogether, these results demonstrated that dietary CE induces CRC cellular senescence via modulating the miR-371b-5p/TFAP4 axis and presents opportunities for potential therapeutic strategies against CRC. +lncRNA target 35191809 hsa-mir-886 Osteosarcoma Overall, OXCT1-AS1 suppresses miR-886 maturation to promote OS cell proliferation. +circRNA target 35191807 hsa-mir-136 Osteoarthritis 5p/NAMPT axis is momentous in OA progression and is supposed to be a promising therapeutic target for some time. +transcription factor target 35191804 hsa-mir-21 Glioblastoma In short, Rop exerted an anti-tumor impact on GBM via mediating the miR +genetics_overexpression_promote 35191803 hsa-mir-130b Triple Negative Breast Neoplasms In TNBC cells, downregulation of BRCAT54 was observed after the overexpression of miR-130b. +genetics_overexpression_promote 35191745 hsa-mir-148a Carcinoma, Squamous Cell, Cutaneous Moreover, miR-148a-3p overexpression inhibited the malignant phenotypes of CSCC cells, with EGFR elevation abrogating the effects. +genetics_knock down_promote 35191420 hsa-mir-217 Carcinoma, Non-Small-Cell Lung Overexpression of miR-217 inhibited the malignant phenotypes of NSCLC cells, while the effects were abrogated by elevating APPBP2. +lncRNA target 35191145 hsa-mir-150 Pancreatic Diseases 3p and suppressed expression of PDX1. +transcription factor target 35191055 hsa-mir-451 Prostatic Hyperplasia We found that TvMIF can enhance RWPE-1 cell proliferation and activate inflammatory factors by suppressing miR-451, thus taking part in the development and proliferation of diseases such as prostatic hyperplasia and prostatitis. +transcription factor target 35191055 hsa-mir-451 Prostatitis We found that TvMIF can enhance RWPE-1 cell proliferation and activate inflammatory factors by suppressing miR-451, thus taking part in the development and proliferation of diseases such as prostatic hyperplasia and prostatitis. +transcription factor target 35190902 hsa-mir-22 autosomal recessive congenital bilateral absence of vas deferens These results indicate that miR-22 is an important accelerator of the osteogenic differentiation of VICs, and a potential therapeutic target in CAVD. +other 35190902 hsa-mir-22 Heart Valve Diseases miR-22 was highly expressed in calcified valve tissues (P < 0.01), and the expression was positively correlated with the expression of OPN (r(s) = 0.820, P < 0.01) and Runx2 (r(s) = 0.563, P < 0.01) in VICs isolated from mild or moderately calcified valves. +lncRNA target 35190765 hsa-mir-296 Femur Head Necrosis CONCLUSION: lncRNA FGD5-AS1 promotes cell proliferation and inhibits apoptosis in steroid-induced ONFH through acting as a sponge for miR5p and upregulation of STAT3. +other 35190587 hsa-mir-18b Colorectal Neoplasms 3p and miR-718 affected glycolysis only, while miR-1181 only regulated CRC respiration. +other 35190587 hsa-mir-145 Colorectal Neoplasms 3p and miR-718 affected glycolysis only, while miR-1181 only regulated CRC respiration. +other 35190587 hsa-mir-718 Colorectal Neoplasms 3p and miR-718 affected glycolysis only, while miR-1181 only regulated CRC respiration. +other 35190587 hsa-mir-376b Colorectal Neoplasms 3p and miR-718 affected glycolysis only, while miR-1181 only regulated CRC respiration. +other 35190587 hsa-mir-676 Colorectal Neoplasms 3p and miR-718 affected glycolysis only, while miR-1181 only regulated CRC respiration. +other 35190532 hsa-mir-1184 Adenocarcinoma of Lung Collectively, the circNEIL3/miR-1184/PIF1 axis that mediate pyroptosis induction may be a novel, promising therapeutic strategy for the clinical treatment of lung cancer. +lncRNA target 35189958 hsa-mir-203a Carcinoma, Pancreatic Ductal Mechanistically, circCUL2 functioned as a ceRNA and modulated the miR-203a-3p/MyD88/NF-kappaB/IL6 axis, thereby further activating the STAT3 signaling pathway in pancreatic cancer cells to induce PDAC progression. CONCLUSIONS: We showed that the circCUL2/miR-203a-5p/MyD88/NF-kappaB/IL6 axis contributes to the induction of iCAFs and established a distinct fibroblast niche for PDAC progression, which could help the development of strategies that selectively target tumor-promoting CAFs in PDAC. +exosome 35189518 hsa-let-7i Silicotuberculosis The study demonstrates that hucMSCs-Exos act as a mediator that transfers let-7i-5p to inhibit the activation of fibroblasts, which alleviates PF through the TGFBR1/Smad3 signaling pathway. +other 35189426 hsa-mir-1 Colonic Neoplasms 3p couldn't identify a subgroup of patients with right-sided RAS-wt mCRC who might benefit from anti-EGFR and suggest that Beva is the TT of choice in first-line treatment of these patients. +lncRNA target 35189053 hsa-mir-526b Melanoma OBJECTIVE: To investigate the mechanism of LINC00518 affecting the proliferation, invasion, and migration of cutaneous malignant melanoma (CMM) cells via miR-526b-3p/EIF5A2 axis. Transfection of si-LINC00518, miR-526b-5p mimic or si-EIF5A2 weakened the proliferative, migratory, and invasive abilities of melanoma cells, while transfection of miR-526b-5p inhibitor or pcDNA-LINC00518 enhanced the progression of melanoma cells. +other 35189048 hsa-mir-24 Diabetic Nephropathies Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera. +other 35189048 hsa-mir-29c Scleroderma, Systemic Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera. +other 35189048 hsa-mir-29b Scleroderma, Systemic However, miR29b resulted downregulated in SSc sera, whereas no significant differences were found in the expression of miR-29a in the two experimental groups of samples. +other 35189048 hsa-mir-29b Diabetic Nephropathies However, miR29b resulted downregulated in SSc sera, whereas no significant differences were found in the expression of miR-29a in the two experimental groups of samples. +other 35189048 hsa-mir-21 Diabetic Nephropathies Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera. +other 35189048 hsa-mir-125b Scleroderma, Systemic Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera. +other 35189048 hsa-mir-125b Diabetic Nephropathies Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera. +other 35189048 hsa-mir-27b Scleroderma, Systemic Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera. +other 35189048 hsa-mir-27b Diabetic Nephropathies Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera. +other 35189048 hsa-mir-21 Scleroderma, Systemic Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera. +other 35189048 hsa-mir-29a Scleroderma, Systemic However, miR29b resulted downregulated in SSc sera, whereas no significant differences were found in the expression of miR-29a in the two experimental groups of samples. +other 35189048 hsa-mir-181b Scleroderma, Systemic Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera. +other 35189048 hsa-mir-24 Scleroderma, Systemic Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera. +other 35189048 hsa-mir-181b Diabetic Nephropathies Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera. +other 35189048 hsa-mir-29c Diabetic Nephropathies Sera from SSc patients showed significant changes in the expression of a set of fibrosis/EndMT-associated microRNAs (miRNA), including miR-21, miR-92a, miR-24, miR-27b, miR-125b, miR-29c, and miR-181b, which resulted significantly upregulated as compared to healthy donors sera. +other 35189048 hsa-mir-29a Diabetic Nephropathies However, miR29b resulted downregulated in SSc sera, whereas no significant differences were found in the expression of miR-29a in the two experimental groups of samples. +circulation_biomarker_diagnosis_up 35188889 hsa-mir-92a Liver Cirrhosis CONCLUSION: Serum exosomal miR-92a-3p and miR-146a-5p are superior to APRI, FIB-4, and LSM for diagnosing significant fibrosis in CHB patients and offer a promising non-invasive alternative to liver biopsy. +circulation_biomarker_diagnosis_up 35188889 hsa-mir-146a Liver Cirrhosis CONCLUSION: Serum exosomal miR-92a-3p and miR-146a-5p are superior to APRI, FIB-4, and LSM for diagnosing significant fibrosis in CHB patients and offer a promising non-invasive alternative to liver biopsy. +lncRNA target 35188875 hsa-mir-512 Osteoarthritis AFAP1-AS1 could be a potential target to treat osteoarthritis by inhibiting miR +other 35188872 hsa-mir-146b Ovarian Failure, Premature Therefore, BBOX1-AS1 may increase the apoptosis of granulosa cells in POF by sponging miR-146b. +other 35188689 hsa-mir-137 Alzheimer Disease Gold nanourchin enhances detection of Alzheimer's disease biomarker "miRNA-137" Diagnosis of Alzheimer's disease (AD) is a complex task, and at present, neuroimaging such as magnetic resonance imaging and positron emission tomography is commonly used for the diagnosis of AD. This research work developed a new biosensing method with gold nanomaterial to identify AD biomarker of miRNA-137. +circulation_biomarker_diagnosis_ns 35188624 hsa-mir-98 Liver Cirrhosis Serum miR +circulation_biomarker_diagnosis_down 35188450 hsa-mir-211 Osteoporosis, Postmenopausal 5p was down-regulated in the PMOP patients' plasma (in contrast with the healthy controls), and it was positively correlated with Vit-D and BMD levels. +genetics_overexpression_promote 35188403 hsa-mir-125b Squamous Cell Carcinoma of Head and Neck Overexpression of MAP3K9 attenuated the inhibitory effect of miR-125b-5p on viability and glycolysis, and the pro-apoptosis effect of miR-125b-5p in LSCC cells. +genetics_overexpression_promote 35188072 hsa-mir-2355 Carcinoma, Non-Small-Cell Lung Mechanically, we showed that silencing of CircSOD2 and overexpression of miR +lncRNA target 35187800 hsa-mir-128 Pre-Eclampsia In conclusion, BNIP3P1 inhibited trophoblast cell proliferation and enhanced cell apoptosis in preeclampsia by targeting the miR3p/BNIP3/mTOR signaling pathway. +genetics_knock down_suppress 35187761 hsa-mir-503 Carcinoma, Hepatocellular MiR5p inhibition reversed the effects of circ_0011232 knockdown on HCC cell development. +circRNA target 35187741 hsa-mir-558 Intervertebral Disc Degeneration CONCLUSIONS: hsa_circ_0083756 promoted IVDD via targeting the miR-558/TREM1 axis, and hsa_circ_0083756 may serve as a potential therapeutic target for the treatment of IVDD. +genetics_knock down_suppress 35187630 hsa-mir-223 Carcinoma, Hepatocellular CONCLUSION: Hsa_circ_0048674 knockdown decelerated HCC progression through the mediation of the miR +circulation_biomarker_diagnosis_ns 35187084 hsa-mir-483 Sepsis Conclusion: The present study reveals the potential role of plasma EV-miRNAs in the pathogenesis of sepsis and the utility of combining miR +circulation_biomarker_diagnosis_ns 35187084 hsa-let-7d Sepsis Conclusion: The present study reveals the potential role of plasma EV-miRNAs in the pathogenesis of sepsis and the utility of combining miR +genetics_overexpression_suppress 35187068 hsa-mir-125b Adenocarcinoma of Lung Moreover, in vitro experiments indicated that the overexpression of miR-125b-5p significantly inhibited cell proliferation, migration, and invasion and induced cell apoptosis of LUAD. +target gene 35187064 hsa-mir-130a Rhabdomyosarcoma Down-Regulated miR-130a/b Attenuates Rhabdomyosarcoma Proliferation via PPARG. +target gene 35187064 hsa-mir-130b Rhabdomyosarcoma Down-Regulated miR-130a/b Attenuates Rhabdomyosarcoma Proliferation via PPARG. +other 35186962 hsa-mir-199a Critical Illness 3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared. +other 35186962 hsa-mir-199a COVID-19 3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared. +other 35186962 hsa-mir-133a COVID-19 3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared. +other 35186962 hsa-mir-27a COVID-19 3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared. +other 35186962 hsa-mir-222 COVID-19 3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared. +other 35186962 hsa-mir-27a Critical Illness 3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared. +other 35186962 hsa-mir-222 Critical Illness 3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared. +other 35186962 hsa-mir-133a Critical Illness 3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared. +other 35186962 hsa-mir-486 Critical Illness 3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared. +other 35186962 hsa-mir-221 Critical Illness 3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared. +other 35186962 hsa-mir-214 COVID-19 3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared. +other 35186962 hsa-mir-221 COVID-19 3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared. +other 35186962 hsa-mir-214 Critical Illness 3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared. +other 35186962 hsa-mir-486 COVID-19 3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared. +transcription factor target 35186915 hsa-mir-205 Myocardial Reperfusion Injury Bioinformatics analyses and luciferase, pull-down, and RNA-binding immunoprecipitation assays further revealed that lncAABR07025387.1 interacted with miR-205, which directly targeted ACSL4, a known contributor to ferroptosis. These findings suggest that, mechanistically, lncAABR07025387.1 negatively regulates miR-205 expression and subsequently upregulates ACSL4-mediated ferroptosis. +transcription factor target 35186909 hsa-mir-16 Bone Diseases Thus, Mg-HA-C/C composites promote osteogenic differentiation and repair bone defects through inhibiting miR-16. +other 35186758 hsa-mir-934 pancreatic adenocarcinoma To address this issue, we established a panel constructed by four miRNAs (miR2, miR-934, miR-1301 and miR-3655) based on The Cancer Genome Atlas (TCGA) and Human Cancer Metastasis Database (HCMDB) to predicted the prognosis of PAAD patients. +other 35186758 hsa-mir-4444-2 pancreatic adenocarcinoma To address this issue, we established a panel constructed by four miRNAs (miR2, miR-934, miR-1301 and miR-3655) based on The Cancer Genome Atlas (TCGA) and Human Cancer Metastasis Database (HCMDB) to predicted the prognosis of PAAD patients. +other 35186758 hsa-mir-655 pancreatic adenocarcinoma To address this issue, we established a panel constructed by four miRNAs (miR2, miR-934, miR-1301 and miR-3655) based on The Cancer Genome Atlas (TCGA) and Human Cancer Metastasis Database (HCMDB) to predicted the prognosis of PAAD patients. +other 35186758 hsa-mir-1301 pancreatic adenocarcinoma To address this issue, we established a panel constructed by four miRNAs (miR2, miR-934, miR-1301 and miR-3655) based on The Cancer Genome Atlas (TCGA) and Human Cancer Metastasis Database (HCMDB) to predicted the prognosis of PAAD patients. +lncRNA target 35186455 hsa-mir-128 Pancreatic Carcinoma 3p inhibitor in AsPC-1 cells. +circulation_biomarker_prognosis_up 35186240 hsa-mir-1254 Uterine Cervical Neoplasms ABHD11-AS1 decreased and miR-1254 increased in serum of cervical carcinoma patients after treatment (P < 0.05). +lncRNA target 35186236 hsa-mir-511 Breast Neoplasms 5p was a biomarker event for breast cancer, and CCNE1 and CHEK1 served as potential targets of miR +transcription factor target 35186224 hsa-mir-221 Sepsis This experiment mainly discusses the effect of miR-221 on acute liver and kidney injury in septic rats. CONCLUSION: MiR-221 promotes the expression of HECTD2 in septic rats, and inhibition of miR-221 expression can reduce the degree of liver and kidney injury in septic rats. +lncRNA target 35186188 hsa-mir-488 Cardiotoxicity 3p/CyclinG1 as therapeutic targets in doxorubicin-induced cardiovascular diseases. +other 35186170 hsa-mir-7152 Carcinoma, Hepatocellular AC007099.1/miR-7152/FAP was found to be associated with immune infiltration in patients with hepatocellular carcinoma. +circRNA target 35186081 hsa-mir-1290 Stomach Neoplasms CONCLUSION: circACVR2A competitively sponged miR-1290 and was exerted as a tumor suppressor gene oncogene via a circACVR2A/miR-1290 axis, suggesting it as a possible biomarker for GC therapy. +lncRNA target 35186067 hsa-mir-1301 Liver Neoplasms The purpose of this article is to use an improved CNN neural network model algorithm combined to contrast the experimental groups and use deep learning medical imaging technology to study the mechanism by which miR-1301 inhibits the proliferation of carcinoma YD-38 cells through the PI3K/AKT pathway. +other 35186067 hsa-mir-1 Liver Neoplasms 3p on the proliferation ability of liver cancer cells. +target gene 35185415 hsa-mir-873 Uterine Cervical Neoplasms MiRNA-873-5p Acts as a Potential Novel Biomarker and Promotes Cervical Cancer Progression by Regulating ZEB1 via Notch Signaling Pathway. +circulation_biomarker_diagnosis_ns 35185369 hsa-mir-21 Lung Allograft Dysfunction Circulating miR-21 was determined in collected serum samples of CLAD and matched stable recipients. +other 35185288 hsa-mir-139 Stomach Neoplasms hsa_circ_0000218/hsa-miR-139-3p/SOX4 regulatory feedback circuit influences the proliferation and apoptosis of gastric cancer cells. +transcription factor target 35185286 hsa-mir-21 Bone Diseases Collectively, our findings suggested that high-magnitude mechanical strain affected osteoclastic differentiation through modulating the miR-21/PTEN/PI3K/Akt signaling cascade, which provided potential strategies for the treatment of bone-related diseases. +genetics_knock down_promote 35184918 hsa-mir-877 Keloid 5p on the biological functions of keloid fibroblasts could be abolished by EGR1 overexpression. +circulation_biomarker_diagnosis_ns 35184688 hsa-mir-552 Diabetes Mellitus, Type 2 3pin the serum of T2DM patients. +genetics_overexpression_promote 35184686 hsa-mir-144 Thyroid Neoplasms 5p overexpression enhanced the anti-tumor effect of PTX on thyroid carcinoma by targeting STON2. +genetics_knock down_suppress 35184666 hsa-mir-149 Inflammation LINC00917 knockdown restored NPC cellular functions and inhibited IDD progression by modulating the miR5p/NLRP1 axis. +genetics_knock down_suppress 35184666 hsa-mir-149 Syphilis LINC00917 knockdown restored NPC cellular functions and inhibited IDD progression by modulating the miR5p/NLRP1 axis. +genetics_overexpression_suppress 35184646 hsa-mir-378a Carcinoma, Hepatocellular Furthermore, the overexpression of miR-378a-3p hindered cell proliferation and migration but facilitated apoptosis by repressing STAT3 signaling in HCC cells. +genetics_overexpression_suppress 35184643 hsa-mir-489 Retinoblastoma 3p overexpression, respectively. +genetics_knock down_promote 35184456 hsa-mir-1290 Endometrial Neoplasms Knockdown of miR1290 expression can promote the proliferation of endometrial cancer cells, but inhibit cell invasion, migration and EMT ability through the PI3K/Akt and Wnt/beta-catenin pathways. +lncRNA target 35184431 hsa-mir-22 Dementia 5p alleviates vascular dementia development by targeting TSPAN5. +lncRNA target 35184431 hsa-mir-22 Dementia, Vascular 5p alleviates vascular dementia development by targeting TSPAN5. +genetics_overexpression_promote 35184427 hsa-mir-21 Vascular Calcification Our results suggest that overexpression of miR +genetics_overexpression_promote 35184427 hsa-mir-21 Kidney Failure, Chronic Our results suggest that overexpression of miR +genetics_overexpression_promote 35184139 hsa-mir-483 Acute Kidney Injury 5p directly targeted to GPX3, overexpression of which rescued cisplatin-induced AKI by inhibiting oxidative stress and apoptosis of tubular cells, but not by regulating autophagy. +lncRNA target 35184134 hsa-mir-124 Stomach Neoplasms These results primarily demonstrated TGF-beta1 can regulate cancer cell migration, invasion and stimulate EMT through the SND1-IT1/miR-124/COL4A1 axis in GC. +other 35184133 hsa-mir-486 Attention Deficit Disorder with Hyperactivity 5p showed differential trends of DeltaCt values between treatment responders and non-responders. +other 35184133 hsa-mir-27a Attention Deficit Disorder with Hyperactivity 5p showed differential trends of DeltaCt values between treatment responders and non-responders. +other 35184133 hsa-mir-140 Attention Deficit Disorder with Hyperactivity 5p showed differential trends of DeltaCt values between treatment responders and non-responders. +transcription factor target 35183672 hsa-mir-345 Liver Injury 5p, and miR-30e-5p might be involved in CdCl(2)-induced liver injury, in part by dysregulation of lipid metabolism and inflammation. +transcription factor target 35183672 hsa-mir-34a Liver Injury 5p, and miR-30e-5p might be involved in CdCl(2)-induced liver injury, in part by dysregulation of lipid metabolism and inflammation. +circulation_biomarker_diagnosis_up 35183243 hsa-mir-205 Ovarian Neoplasms CONCLUSION: The level of miR-205 in plasma exosomes is a valuable tumor biomarker to improve OC diagnosis. +lncRNA target 35183226 hsa-mir-5586 Pancreatic Carcinoma Moreover, our data revealed that YTHDF3 was a critical target for miR5p, by which forming a negative feedback with DICER1-AS1 to regulate glycolysis of PC. +other 35183135 hsa-mir-6815 Adenocarcinoma of Lung CONCLUSIONS: This study, for the first time, deciphered the regulatory role of FENDRR/miR5p axis in the progression of early-stage LUAD, which is needed to be established in vitro and in vivo. +other 35183057 hsa-mir-93 Stomach Neoplasms Mechanistically, we demonstrated that GPC5-AS1 stabilizes GPC5 mRNA by acting as a molecular sponge for miR-93 and miR-106a, thereby reducing GC tumor progression. +other 35183057 hsa-mir-106a Stomach Neoplasms Mechanistically, we demonstrated that GPC5-AS1 stabilizes GPC5 mRNA by acting as a molecular sponge for miR-93 and miR-106a, thereby reducing GC tumor progression. +transcription factor target 35183007 hsa-mir-214 Cardiomegaly CONCLUSIONS: Collectively, these findings indicate that FTZ is a protective factor for cardiac hypertrophy due to its regulation of the miRSIRT3 axis, which suggests that FTZ may be a therapeutic target for cardiac hypertrophy. +transcription factor target 35183007 hsa-mir-214 Atherosclerosis CONCLUSIONS: Collectively, these findings indicate that FTZ is a protective factor for cardiac hypertrophy due to its regulation of the miRSIRT3 axis, which suggests that FTZ may be a therapeutic target for cardiac hypertrophy. +lncRNA target 35182679 hsa-mir-431 Carcinoma, Pancreatic Ductal 5p acts as a tumour suppressor in PDAC cells, with BxPC-3 cells being most responsive. +genetics_overexpression_promote 35182329 hsa-mir-378b Hemangioma, Cavernous Moreover, FOLS1 was the target of miR-378b, and its overexpression reversed the inhibitory effect of miR-378b overexpression on IH cell tumor-like behaviors in vitro. +target gene 35182064 hsa-mir-181a Leukemia, Myeloid, Acute The Inhibitory Effect of Sulforaphane on The Proliferation of Acute Myeloid Leukemia Cell Lines through Controlling miR-181a. +other 35182062 hsa-mir-29a Diabetic Nephropathies There was a decrease in miRNA-377 (P<0.01) and increase in miRNA-29a (P<0.001) in the diabetic rats. +other 35182062 hsa-mir-377 Diabetic Nephropathies There was a decrease in miRNA-377 (P<0.01) and increase in miRNA-29a (P<0.001) in the diabetic rats. +other 35182016 hsa-mir-124 Alzheimer Disease MicroRNA-124 (miR-124) is the most abundant miRNA in the normal brain with great potency to ameliorate AD-like pathology, while it is deficient in AD brain. Herein, the authors develop a DNA nanoflowers (DFs)-based delivery system to realize exogenous supplementation of miR-124 for AD therapy. +other 35181997 hsa-mir-137 Aortic Diseases Increases in miR-34a and miR-137 with ageing downregulate the expression of Src and paxillin, leading to impaired ERK signalling and aortic contractile dysfunction. +other 35181997 hsa-mir-34a Aortic Diseases Increases in miR-34a and miR-137 with ageing downregulate the expression of Src and paxillin, leading to impaired ERK signalling and aortic contractile dysfunction. +transcription factor target 35181869 hsa-mir-139 Adenocarcinoma of Lung Mechanistically, miR5p might negatively regulate CCNB1 in LUAD, thereby suppressing cell proliferation, migration, invasion and cell cycle. +circRNA target 35181843 hsa-mir-361 Ovarian Neoplasms RAB1A was a downstream target of miR +circulation_biomarker_diagnosis_ns 35181820 hsa-mir-92a Infertility Elevated expression of miR-92a-3p in post-pubertal testes results into functionally compromised Sc, leading to impairment of the blood-testis barrier formation and apoptosis of pre-meiotic Gc, ultimately culminating into infertility. +other 35181820 hsa-mir-92a Infertility, Male Collectively, our data suggest that regulation of miR-92a-3p expression is crucial for Sc-mediated induction of active spermatogenesis at puberty and regulation of male fertility. +circRNA target 35181624 hsa-mir-485 Carcinoma, Non-Small-Cell Lung 5p plays a crucial role in the progression of non-small cell lung cancer by regulating HSP90 function, thereby may be an inhibition therapeutic target of non-small cell lung cancer. +other 35181620 hsa-mir-126 Carcinoma, Hepatocellular Also, we detected a low expression level of miR-126 in HCC and CCA cell lines. +circulation_biomarker_diagnosis_up 35181618 hsa-mir-142 Osteoporosis METHODS: Clinical serum samples collected from 30 osteoporosis patients were utilized to obtain circ_0006873 and miR +genetics_overexpression_suppress 35181613 hsa-mir-654 Wilms Tumor Overexpression of miR +circulation_biomarker_diagnosis_ns 35181587 hsa-mir-371a Testicular Neoplasms 3p nor miR-371a-3p are suitable as circulating teratoma markers. +circulation_biomarker_diagnosis_up 35180915 hsa-mir-124 Cerebral Infarction, Lacunar MSN-encapsulated miR-124 inhibitor increased the expression of SCF/c-kit protein by targeting P2Y(12), thereby enhancing regeneration of cerebral blood vessels in LCI. +lncRNA target 35180913 hsa-mir-455 Myocardial Infarction 5p significantly inhibited the expression of SOCS3 and resulted in the increased protection of cells damaged by H(2)O(2), which was used as a model of myocardial infarction. +transcription factor target 35180673 hsa-mir-18b Shock, Hemorrhagic MiR-18b-5p was highly expressed in the spleen of hemorrhagic shock rats detected by the qRT-PCR assay. Taken together, miR-18b-5p may be a novel therapeutic candidate target in splenic hemorrhagic shock treatment. +circRNA target 35180547 hsa-mir-299 Squamous Cell Carcinoma of Head and Neck CONCLUSION: Our present findings first demonstrate that circ_OSBPL10 can regulate the functional behaviors of OSCC cells at least partially by miR3p/CDK6 axis, highlighting circ_OSBPL10 as a promising therapeutic target for OSCC. +lncRNA target 35180020 hsa-mir-34a Cataract, Age-Related Nuclear PURPOSE: MiR-34a-5p is reported to be related with age-related nuclear cataract. These data suggest that miR-34a-5p may be a potential novel therapeutic target for the prevention and treatment of age-related cataract. +lncRNA target 35180001 hsa-mir-203a Osteoarthritis We elucidated how maclurin promotes the chondrogenic differentiation of BMSCs by regulating miR-203a-3p/Smad1, which provides a strategy for future exploration of osteoarthritis therapy through cell transplantation. +lncRNA target 35179718 hsa-mir-9 Triple Negative Breast Neoplasms 5p/LZTS2 axis may be a novel biomarker and therapeutic target for TNBC patients. +genetics_overexpression_promote 35179516 hsa-mir-154 Hepatoblastoma 3p inhibitor and ROCK1 overexpression were able to reverse the effect of downregulated Linc00205 on proliferation, migration, invasion, and apoptosis of HB cells by rescue assays via mitogen-activated protein kinase (MAPK) signaling. +circulation_biomarker_diagnosis_up 35179443 hsa-mir-181 Diabetic Retinopathy CONCLUSIONS: MiR-181 is upregulated in plasma and aqueous humor of DR patients. +genetics_knock down_promote 35179434 hsa-mir-545 Ovarian Neoplasms Gain- and loss-of functions of circ_0067934, miR +genetics_knock down_promote 35179324 hsa-mir-155 Cancer-Associated Cachexia Moreover, overexpression of miR-155 in GC exosomes improved CAC in vivo, which was characterized by fat loss, suppressed expressions of C/EPB, C/EPB, and PPAR in A-MSCs, and high expression of UCP1 (P < 0.05). +genetics_knock down_promote 35179324 hsa-mir-155 Stomach Neoplasms Moreover, overexpression of miR-155 in GC exosomes improved CAC in vivo, which was characterized by fat loss, suppressed expressions of C/EPB, C/EPB, and PPAR in A-MSCs, and high expression of UCP1 (P < 0.05). +circRNA target 35179220 hsa-mir-182 Kidney Neoplasms Overall, the circKL/miR1825p/FBXW7 axis was indicated to have a key role in the growth and metastasis of kidney cancer and may be targeted as a novel therapeutic strategy. +other 35178994 hsa-mir-17 Atherosclerosis astragaloside Ⅳ against atherosclerosis by regulating miR-17-5p and PCSK9/VLDLR signal pathway +lncRNA target 35178162 hsa-mir-423 Osteochondritis Dissecans It was concluded that HBO attenuated NSC pyroptosis via lncRNA-H19/miR +circulation_biomarker_diagnosis_up 35178127 hsa-mir-125a Depression Small RNA sequencing revealed 11 deregulated circulating miRNAs in MDD and BD plasma, of which expression of 5, hsa-miR +circulation_biomarker_diagnosis_up 35178127 hsa-let-7e Depression Small RNA sequencing revealed 11 deregulated circulating miRNAs in MDD and BD plasma, of which expression of 5, hsa-miR +circulation_biomarker_diagnosis_up 35177926 hsa-mir-139 Colonic Neoplasms RESULTS: Compared with control group, significantly lower expression level of serum miR +tissue_expression_ns 35177192 hsa-mir-21 Myocardial Infarction, Acute MZB cell deficiency and MZB cell-specific deletion of miR21 or Hif1a improved cardiac function after acute MI. +other 35177076 hsa-mir-423 Polycystic Ovary Syndrome RESULTS: Circ_FURIN and MTM1 expressions were significantly upregulated, whereas miR5p was downregulated in the ovarian cortex tissues of PCOS patients and TTR-treated KGN cells compared with controls. +lncRNA target 35177060 hsa-mir-497 Poikiloderma with Neutropenia CONCLUSIONS: GAS promotes the recovery of PNI via modulating miR-497 / BDNF axis and inhibiting oxidative stress. +lncRNA target 35177003 hsa-mir-214 Atherosclerosis 5p/COX20 axis, suggesting that DANCR might be a potential therapeutic target for AS. +lncRNA target 35176945 hsa-mir-143 Nasopharyngeal Carcinoma It is concluded that the down-regulated LHFPL3-AS1 retards the development of radiation-resistant NPC cells via sponging miR +genetics_knock down_promote 35176937 hsa-mir-633 Colorectal Adenocarcinoma Our results demonstrated that knockdown of PCED1B-AS1 inhibited the progression of colorectal adenocarcinoma by regulating the miR-633/HOXA9 axis. +other 35176332 hsa-mir-34a Head and Neck Neoplasms Profiling of the radiation response in the UM-SCC-1 head and neck cancer cell line confirmed reduced metabolic activity and increased radiation induced apoptosis upon treatment with miR-34a-HDL NPs. The radio-sensitising properties of miR-34a-HDL NPs were further confirmed in a more biologically relevant co-culture spheroid model of head and neck cancer. +lncRNA target 35176309 hsa-mir-373 Pancreatic Carcinoma PHLPP2 axis, leading to AKT dephosphorylation, and cyclin D1 and transforming growth factor-beta down-regulation to suppress tumor growth and muscle wasting in pancreatic cancer. +lncRNA target 35176309 hsa-mir-373 Muscular Atrophy PHLPP2 axis, leading to AKT dephosphorylation, and cyclin D1 and transforming growth factor-beta down-regulation to suppress tumor growth and muscle wasting in pancreatic cancer. +circulation_biomarker_diagnosis_ns 35175475 hsa-mir-221 Breast Neoplasms We studied interrelationships between the cytoarchitectonics of the mesenteric lymph node and the levels of microRNA-21, microRNA-221/222, and microRNA-429 in the lymph, blood serum, and breast tissues in female Wistar rats with chemically induced breast cancer. +circulation_biomarker_diagnosis_ns 35175475 hsa-mir-429 Breast Neoplasms We studied interrelationships between the cytoarchitectonics of the mesenteric lymph node and the levels of microRNA-21, microRNA-221/222, and microRNA-429 in the lymph, blood serum, and breast tissues in female Wistar rats with chemically induced breast cancer. +circulation_biomarker_diagnosis_ns 35175475 hsa-mir-222 Breast Neoplasms We studied interrelationships between the cytoarchitectonics of the mesenteric lymph node and the levels of microRNA-21, microRNA-221/222, and microRNA-429 in the lymph, blood serum, and breast tissues in female Wistar rats with chemically induced breast cancer. +circulation_biomarker_diagnosis_ns 35175475 hsa-mir-21 Breast Neoplasms We studied interrelationships between the cytoarchitectonics of the mesenteric lymph node and the levels of microRNA-21, microRNA-221/222, and microRNA-429 in the lymph, blood serum, and breast tissues in female Wistar rats with chemically induced breast cancer. +other 35175428 hsa-mir-491 Glioblastoma 5p and hsa-miR-1290, were solely associated to glioblastoma. +other 35175428 hsa-mir-485 Glioblastoma 5p and hsa-miR-1290, were solely associated to glioblastoma. +other 35175428 hsa-mir-1290 Brain Neoplasms 5p and hsa-miR-1290, were solely associated to glioblastoma. +other 35175428 hsa-mir-491 Brain Neoplasms 5p and hsa-miR-1290, were solely associated to glioblastoma. +other 35175428 hsa-mir-485 Brain Neoplasms 5p and hsa-miR-1290, were solely associated to glioblastoma. +other 35175428 hsa-mir-338 Brain Neoplasms 5p and hsa-miR-1290, were solely associated to glioblastoma. +other 35175428 hsa-mir-338 Glioblastoma 5p and hsa-miR-1290, were solely associated to glioblastoma. +other 35175428 hsa-mir-21 Glioblastoma 5p and hsa-miR-1290, were solely associated to glioblastoma. +other 35175428 hsa-mir-21 Brain Neoplasms 5p and hsa-miR-1290, were solely associated to glioblastoma. +other 35175428 hsa-mir-1290 Glioblastoma 5p and hsa-miR-1290, were solely associated to glioblastoma. +other 35174774 hsa-mir-197 Glioma 3p/CKS1B axis, highlighting a novel competing endogenous RNA circuit of glioma progression. +lncRNA target 35174753 hsa-mir-130b Osteoarthritis CONCLUSION: This study provided evidence that EVs alleviate chondrocyte damage during OA through miR-130b-3p-mediated inhibition of the LRP12/AKT/beta-catenin axis. +circRNA target 35174654 hsa-mir-1299 Breast Neoplasms CONCLUSIONS: Circ_0001955 was found to promote breast cancer malignant development via targeting of the miR-1299/GLUT1 pathway, which contributes to our understanding of the pathogenesis of breast cancer. +other 35174434 hsa-mir-122 Hypertension 5p exacerbates myocardial fibrosis and dysfunction in hypertensive rats by modulating the elabela/apelin-ACE2-GDF15 signaling. +other 35174434 hsa-mir-122 Myocardial Fibrosis 5p exacerbates myocardial fibrosis and dysfunction in hypertensive rats by modulating the elabela/apelin-ACE2-GDF15 signaling. +lncRNA target 35174294 hsa-mir-25 Reperfusion Injury, Renal Ischemia 3p may target DKK3 to reduce renal cell damage caused by hypoxia and that miR +other 35174066 hsa-mir-1269a Carcinoma, Hepatocellular Survival analysis of clinical samples showed that hsa-mir-1269a, hsa-mir-421 were associated with prognosis (p<0.05).This study revealed the general expression characteristics of specific differentially expressed miRNAs using a ceRNA network constructed from HCC samples. +other 35174066 hsa-mir-421 Carcinoma, Hepatocellular Survival analysis of clinical samples showed that hsa-mir-1269a, hsa-mir-421 were associated with prognosis (p<0.05).This study revealed the general expression characteristics of specific differentially expressed miRNAs using a ceRNA network constructed from HCC samples. +circulation_biomarker_diagnosis_up 35173872 hsa-mir-384 Spinal Cord Injuries OBJECTIVE: To explore the mechanism of circ_014260 regulating neuronal apoptosis, oxidative stress, and endoplasmic reticulum stress in rats with spinal cord injury (SCI) via miR-384/THBS1 axis. +circulation_biomarker_prognosis_ns 35173845 hsa-mir-124 Brain Injuries OBJECTIVE: To explore the correlation of serum levels of microRNA (miRNA)-124 and miRNA-210 with brain injury and inflammatory response (IR) in patients with craniocerebral injury (CI) at early stage. CONCLUSION: The elevated levels of serum miRNA-124 and miRNA-210 in patients with CI are closely related to the aggravation of brain injury, overactivation of the IR, and prognosis. +circulation_biomarker_prognosis_ns 35173845 hsa-mir-124 Craniocerebral Trauma OBJECTIVE: To explore the correlation of serum levels of microRNA (miRNA)-124 and miRNA-210 with brain injury and inflammatory response (IR) in patients with craniocerebral injury (CI) at early stage. CONCLUSION: The elevated levels of serum miRNA-124 and miRNA-210 in patients with CI are closely related to the aggravation of brain injury, overactivation of the IR, and prognosis. +circulation_biomarker_prognosis_ns 35173845 hsa-mir-210 Craniocerebral Trauma OBJECTIVE: To explore the correlation of serum levels of microRNA (miRNA)-124 and miRNA-210 with brain injury and inflammatory response (IR) in patients with craniocerebral injury (CI) at early stage. CONCLUSION: The elevated levels of serum miRNA-124 and miRNA-210 in patients with CI are closely related to the aggravation of brain injury, overactivation of the IR, and prognosis. +circulation_biomarker_prognosis_ns 35173845 hsa-mir-210 Brain Injuries OBJECTIVE: To explore the correlation of serum levels of microRNA (miRNA)-124 and miRNA-210 with brain injury and inflammatory response (IR) in patients with craniocerebral injury (CI) at early stage. CONCLUSION: The elevated levels of serum miRNA-124 and miRNA-210 in patients with CI are closely related to the aggravation of brain injury, overactivation of the IR, and prognosis. +genetics_overexpression_promote 35173840 hsa-mir-1179 Carcinoma, Hepatocellular Overexpression of NUAK2 can reverse the effect of miR-1179 on hepatocellular carcinoma cells. +genetics_overexpression_promote 35173832 hsa-mir-122 Fibrosis, Renal 5p or overexpression of PKM could promote apoptosis of TGF-beta1-treated HK2 cells, inhibit their viability, aggravate fibrosis, and attenuate the protective effect of RR on the cells. +other 35173821 hsa-mir-532 Prostatic Diseases 5p showed a significant differential expression within the group of patients with PCa in a training subset of the data containing 32 patients. +other 35173821 hsa-mir-6749 Prostatic Diseases 5p showed a significant differential expression within the group of patients with PCa in a training subset of the data containing 32 patients. +other 35173610 hsa-mir-342 Carcinoma, Hepatocellular Rescue assays validated the LINC01134/miR3p/MAPK1 axis in the radio-resistant HCC cells. +transcription factor target 35173533 hsa-mir-484 dystonia 5 We found that miR-484 was highly expressed in GCs from DOR patients and was correlated with decreasing AMH levels and AFC, as well as increasing FSH levels, but not with LH, progesterone, or estradiol. The present study indicates that miR-484 can directly target the mRNA of YAP1, induce mitochondrial dysfunction, and consequently reduce the viability and promote the apoptosis of granulosa cells, which contributes to the pathogenesis of DOR. +transcription factor target 35173533 hsa-mir-484 Mitochondrial Diseases Moreover, we found that miR-484 repressed the proliferation of GCs and induced apoptosis, which can in part be attributed to mitochondrial dysfunction. The present study indicates that miR-484 can directly target the mRNA of YAP1, induce mitochondrial dysfunction, and consequently reduce the viability and promote the apoptosis of granulosa cells, which contributes to the pathogenesis of DOR. +lncRNA target 35173533 hsa-mir-484 Corneal dystrophy, epithelial basement membrane Multiple approaches, including bioinformatic analysis, RNA-seq, qPCR, immunofluorescence, western blotting and luciferase reporter assays, identified YAP1 as a direct target of miR-484 in GCs. +circulation_biomarker_diagnosis_ns 35173476 hsa-mir-155 Hepatitis C BACKGROUND: To investigate the expression of serum miR-155 and miR-224 among patients with hepatitis C virus (HCV) infection and analyze their clinical values. +circulation_biomarker_diagnosis_ns 35173476 hsa-mir-224 Hepatitis C BACKGROUND: To investigate the expression of serum miR-155 and miR-224 among patients with hepatitis C virus (HCV) infection and analyze their clinical values. +genetics_overexpression_promote 35173455 hsa-mir-24 Uterine Diseases CONCLUSION: Our findings demonstrate that the overexpression of miR3p attenuates endometrial inflammation and the expression of pro-inflammatory mediators via suppressing TRAF6. +other 35173455 hsa-mir-24 Endometritis The present study intends to investigate the regulatory role of miR3p in the innate immune response involved in endometritis and evaluate its therapeutic potential. +lncRNA target 35173453 hsa-mir-155 psoriasis 1 Inhibitions of both TLR4 pathway and miR-155 further corrected abnormalities of proliferation and the above biomarkers in CD14(+) monocytes from psoriatic patients. +exosome 35173168 hsa-let-7 Breast Neoplasms Moreover, Lin28B-induced breast cancer stem cells are the main sources of low-let-7s exosomes. +lncRNA target 35173146 hsa-mir-374b Carcinoma, Renal Cell In conclusion, the circAFAP1/miR-374b-3p/VEGFA axis played a critical role in the progression and development of ccRCC which might be novel biological marks and therapeutical targets. +other 35173110 hsa-mir-363 Acute Lung Injury 3p/S1PR1 axis-mediated protective effect on septic ALI. +genetics_GWAS 35172717 hsa-mir-486 Osteosarcoma 5p represents a highly cancer relevant, epigenetically regulated miRNA in osteosarcoma, and this knowledge contributes to the understanding of osteosarcoma biology. +epigenetics 35172677 hsa-mir-29b Depression EZH2 inhibited miR-29b-3p expression by combining with miR-29b-3p promoter and trimethylation of histone H3-lysine 27-trimethylated upregulation, and then elevated MMP2 transcription and triggered microglia M1-type polarization, thus exacerbating depression-like behaviors and neuroinflammation of depression. +circRNA target 35172672 hsa-mir-497 Sepsis In conclusion, this work showed circVMA21 improved LI in sepsis rats by targeting miR5p/CD2AP axis, suggesting that circVMA21 may be a novel therapeutic target for sepsis-induced LI. +circRNA target 35172672 hsa-mir-497 Lung Injury In conclusion, this work showed circVMA21 improved LI in sepsis rats by targeting miR5p/CD2AP axis, suggesting that circVMA21 may be a novel therapeutic target for sepsis-induced LI. +genetics_overexpression_promote 35172671 hsa-mir-15b spondyloepimetaphyseal dysplasia, Strudwick type Notably, YAP1 overexpression attenuated the inhibitory effects of miR-15b-5p up-regulation on the proliferation, migration, and inflammatory response, as well as ECM deposition of TNF-alpha-induced ASM cells. +other 35172671 hsa-mir-15b Asthma In conclusion, miR-15b-5p/YAP1 axis modulates the growth, migration, inflammatory response, and ECM deposition of ASM cells, thus participating in the pathogenesis of asthma. +genetics_GWAS 35172669 hsa-mir-24 Osteoarthritis 5p/BMPR2 axis.Abbreviations OA: osteoarthritis; BMPR2: bone morphogenetic protein type 2 receptor. +genetics_knock down_promote 35172608 hsa-mir-493 Fibrosis, Renal Overexpression of circPlekha7 or knockdown of miR +transcription factor target 35172278 hsa-mir-185 Atherosclerosis 5p effectively alleviates atherosclerosis and lipid accumulation by regulating the miR +transcription factor target 35172278 hsa-mir-185 Lipidoses 5p effectively alleviates atherosclerosis and lipid accumulation by regulating the miR +other 35171545 hsa-mir-146a Arthritis, Rheumatoid In conclusion, data of this study suggested a possible association between miRNA 146a-5p expression level and the incidence of RA in Egyptian patients. +lncRNA target 35171433 hsa-mir-125 Cerebral Hemorrhage The present findings demonstrate that IRE1alpha inhibition attenuates mast cells degranulation and neuroinflammation, at least partially, through IRE1alpha/miR-125/Lyn signaling pathway after ICH. +lncRNA target 35171433 hsa-mir-125b-2 Cerebral Hemorrhage Inhibition of IRE1alpha, with STF083010, remarkably reduced brain water content, improved neurological function, decreased hematoma volume, upregulated the expression of miR-125b3p, decreased the number of mast cells, and downregulated the protein expression of Lyn kinase, XBP1s (spliced X-box binding protein-1), tryptase, IL-17A and TNF-alpha. +genetics_overexpression_promote 35171402 hsa-mir-466 Colorectal Neoplasms LINC 01436 is overexpressed in CRC and promotes cancer cell proliferation by suppressing miR-466 maturation. +genetics_overexpression_suppress 35171359 hsa-mir-24 Osteosarcoma 3p overexpression inhibited the proliferation and chemoresistance of OS cells. +circulation_biomarker_diagnosis_ns 35171328 hsa-mir-371a Neoplasms, Germ Cell, Intracranial CONCLUSION: With the largest data set so far, we underline the suitability of miR-371a, miR-372, miR-367 and miR-302d in serum and CSF for diagnosis of iGCT, particularly in biomarker-negative germinoma. +circulation_biomarker_diagnosis_ns 35171328 hsa-mir-372 Neoplasms, Germ Cell, Intracranial CONCLUSION: With the largest data set so far, we underline the suitability of miR-371a, miR-372, miR-367 and miR-302d in serum and CSF for diagnosis of iGCT, particularly in biomarker-negative germinoma. +circulation_biomarker_diagnosis_ns 35171328 hsa-mir-367 Neoplasms, Germ Cell, Intracranial CONCLUSION: With the largest data set so far, we underline the suitability of miR-371a, miR-372, miR-367 and miR-302d in serum and CSF for diagnosis of iGCT, particularly in biomarker-negative germinoma. +transcription factor target 35171066 hsa-mir-29b Asthma, Severe OBJECTIVE: To examine the relationship between Nrf2-miR-29b axis and SA, and to detect whether preventive use of GSPE relieves SA via it. +lncRNA target 35171050 hsa-mir-30 Acute Lung Injury 5p/ROCK2 pathway, providing a therapeutic target for ALI. +other 35170486 hsa-mir-23c Norrie disease Using quantitative polymerase chain reaction and western blotting, we found that circ-GNB4 and early growth response factor 1 (EGR1) were upregulated, whereas microRNA (miR)-23c was downregulated in DN patients' sera and HG-stimulated HRMCs. Collectively, circ-GNB4 might be a novel mechanism of DN-induced HRMCs injury, and there was a circ-GNB4/miR-23c/EGR1 pathway underlying the proliferation, extracellular matrix accumulation, inflammation and oxidative stress. +other 35170486 hsa-mir-23c Inflammation Collectively, circ-GNB4 might be a novel mechanism of DN-induced HRMCs injury, and there was a circ-GNB4/miR-23c/EGR1 pathway underlying the proliferation, extracellular matrix accumulation, inflammation and oxidative stress. +lncRNA target 35170388 hsa-mir-675 Subarachnoid Hemorrhage Therefore, the administration of MT increased the levels of H19 and miR-675 which have been inhibited by SAH. Therefore, the treatment with MT could ameliorate post-SAH DBI.Running title: Melatonin ameliorates post-SAH DBI via H19/miR-675/HIF1A/TLR4 signaling pathways. +genetics_overexpression_promote 35170385 hsa-mir-122 Peritoneal Fibrosis 5p overexpression showed a deterioration effect on PD-related PF by targeting Smad5 to activate Wnt/beta-catenin pathway. +lncRNA target 35170375 hsa-mir-421 Inflammation Up-regulation of miR-421 or down-regulation of XIAP could reverse the suppressive effects of SNHG16 on OS and cell inflammation. +target gene 35170374 hsa-mir-1299 Stomach Neoplasms Hsa_circ_0005230 is up-regulated and promotes gastric cancer cell invasion and migration via regulating the miR-1299/RHOT1 axis. +genetics_overexpression_promote 35170372 hsa-mir-140 Carcinoma, Non-Small-Cell Lung Overexpression of HOXB5 mitigated miR +genetics_GWAS 35170354 hsa-mir-137 Alzheimer Disease Aims: In this study, the authors hypothesized that, in an in vitro Alzheimer's disease model, the epigenetic axis of SNHG19/hsa-miR-137 functionally regulates amyloid beta peptide 25-35 (Abeta(25-35))-induced SH-SY5Y cytotoxicity. Conclusions: The authors concluded that the epigenetic axis of SNHG19/hsa-miR-137/TNFAIP1 may functionally regulate Abeta(25-35)-induced SH-SY5Y cytotoxicity, thus making it a potential molecular target for Alzheimer's disease treatment. +circRNA target 35170199 hsa-mir-34c Carcinoma, Hepatocellular Mechanistically, Circ_0003945 might exert as a miR-34c-5p sponge to upregulate the expression of leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4), activating the beta-catenin pathway, and finally facilitating HCC progression. In conclusion, Circ_0003945 exerts a tumour-promoting role in HCC cells by regulating the miR-34c-5p/LGR4/beta-catenin axis, which may be a potential target for HCC therapy. +genetics_knock down_suppress 35169903 hsa-mir-597 Carcinoma, Hepatocellular 5p was demonstrated to function in HCC progression by targeting TEAD1 via TEAD1 expression gain and loss. +genetics_knock down_promote 35169864 hsa-mir-497 Breast Neoplasms By contrast, knockdown of DDX11AS1 expression inhibited PTX resistance of breast cancer cells, and suppressed the proliferation, invasion and migration of breast cancer cells, which was achieved via upregulation of miR497 expression. In conclusion, knockdown of lncRNA DDX11AS1 could inhibit the proliferation, migration and PTX resistance of breast cancer cells by upregulating miR497 expression. +other 35169383 hsa-mir-146 Prediabetic State CONCLUSIONS/INTERPRETATION: This study did not replicate in Latinos prior observations from other racial groups of associations between miR-126, miR-146a, and miR-15 and risk for type 2 diabetes. +other 35169383 hsa-mir-126 Prediabetic State CONCLUSIONS/INTERPRETATION: This study did not replicate in Latinos prior observations from other racial groups of associations between miR-126, miR-146a, and miR-15 and risk for type 2 diabetes. +other 35169383 hsa-mir-15 Prediabetic State CONCLUSIONS/INTERPRETATION: This study did not replicate in Latinos prior observations from other racial groups of associations between miR-126, miR-146a, and miR-15 and risk for type 2 diabetes. +other 35169383 hsa-mir-146a Prediabetic State CONCLUSIONS/INTERPRETATION: This study did not replicate in Latinos prior observations from other racial groups of associations between miR-126, miR-146a, and miR-15 and risk for type 2 diabetes. +circulation_biomarker_diagnosis_ns 35169355 hsa-mir-21 Prostatic Neoplasms CONCLUSION: miRNA-21 could serve as biomarkers of prostate cancer progressivity since remarkable diagnostic value of circulating miRNA-21 in prostate cancer metastasis process. +lncRNA target 35168722 hsa-mir-122 Liver Injury Herein, by coupling the target sequence recycling with the primer exchange reaction (PER), a highly sensitive and non-label approach is constructed to detect miRNA-122, the biomarker for drug-induced liver injury. +genetics_knock down_promote 35168653 hsa-mir-1294 Uterine Cervical Neoplasms CONCLUSION: CircCDK17 knockdown repressed cell proliferation, migration, invasion and glycolysis, and promoted cell apoptosis via miR-1294/YWHAZ axis in CC. +lncRNA target 35168644 hsa-mir-92a Ovarian Neoplasms Inhibited OIP5-AS1 or downregulated ITGA6 or elevated miR-92a repressed EMT, viability, migration and invasion, and promoted apoptosis of OC cells. +genetics_knock down_promote 35168468 hsa-mir-383 Colorectal Neoplasms Interfering with miR-383 expression reversed the inhibitory effect of circ_0068464 knockdown on CRC cells. +other 35168080 hsa-mir-377 Acute Kidney Injury CONCLUSION: This study suggested that mmu_circ_0000943 participated in progression of renal IRI by sponging miR3p with Egr2, providing a new insight into AKI treatment. +genetics_knock down_suppress 35167942 hsa-mir-28 Alzheimer Disease Moreover, BACE1 overexpression aggravated neuron injury and inflammation, as well as attenuated the effect of miR-328 overexpression on these functions in cellular AD models. +genetics_GWAS 35167433 hsa-mir-4429 Carcinoma, Non-Small-Cell Lung Additionally, miR-4429 is associated with EGFR mutation in NSCLC patients. +lncRNA target 35167383 hsa-mir-143 Thyroid Cancer, Papillary Conclusion: The present results suggest that silencing lncRNA SLC16A1-AS1 can induce ferroptosis through miR3p/SLC7A11 signaling in renal cancer. +lncRNA target 35167383 hsa-mir-143 Carcinoma, Renal Cell Conclusion: The present results suggest that silencing lncRNA SLC16A1-AS1 can induce ferroptosis through miR3p/SLC7A11 signaling in renal cancer. +genetics_knock down_promote 35167195 hsa-mir-636 Lung Neoplasms CONCLUSION: Circ_0010235 knockdown inhibited lung cancer progression and increased antitumor immunity by regulating the miR-636/PDL1 axis. +genetics_knock down_promote 35166986 hsa-mir-423 Ovarian Neoplasms Knockdown of CRNDE inhibited cell proliferation, migration and invasion of ovarian cancer via miR +other 35166984 hsa-mir-145 Ovarian Neoplasms Furthermore, the miR5p/ELF2 axis was involved in the regulation of PRNCR1 in OC progression in vivo. +genetics_overexpression_promote 35166647 hsa-mir-363 Colorectal Neoplasms 3p was markedly under-expressed in CRC tissues and cells, and its overexpression suppressed the viability, migration, and invasion of CRC cells, and promoted cell apoptosis, whereas inhibiting miR +genetics_knock down_promote 35166635 hsa-mir-661 Osteosarcoma The suppression of circ_0016347 impeded proliferation, migration, invasion, and cell cycle and induced apoptosis in osteosarcoma cells, which was overturned by knockdown of miR-661. +genetics_knock down_promote 35166634 hsa-mir-545 Carcinoma, Pancreatic Ductal 3p mimicked the effects of circ_0072088 knockdown in PDAC cell in vitro. +other 35166206 hsa-mir-188 Lung Neoplasms Further research to explore the potential therapeutic value of miR5p, both as a biomarker and as a drug candidate for the management of metastatic lung cancer may be warranted. +lncRNA target 35166173 hsa-mir-122 Diabetic Nephropathies 5p suppressed the expression of factor inhibiting hypoxia-inducible factor-1 (FIH-1) in vitro models of DN. +genetics_knock down_promote 35166172 hsa-mir-654 Uterine Cervical Neoplasms Hence, circRNA_0000285 knockdown suppressed cell viability and promoted apoptosis by targeting miR +lncRNA target 35166074 hsa-mir-205 Rotator Cuff Injuries OBJECTIVES: To investigate the function and mechanism of miR-205/MeCP2 pathway on the proliferation, migration and fibrosis of rotator cuff tenocytes, in order to provide a new perspective on the repair of rotator cuff tear injury. CONCLUSIONS: The inhibition of MECP2 reversed the effect of miR-205 inhibitor on tenocytes, including the proliferation and migration of tenocytes, indicating that miR-205 may be valuable in miRNA-based therapies for rotator cuff injury. +other 35166053 hsa-mir-516a Carcinoma, Non-Small-Cell Lung Our newly identified RNASEH1-AS1/miR-516a-5p/FOXK1/Wnt/beta-catenin network may offer an interesting foundation for NSCLC treatment in the clinic. +circRNA target 35166026 hsa-mir-6751 Lung Neoplasms CONCLUSION: Circ_0002360 targeted miR3p to regulate ZNF300 level, thus elevating DDP resistance and promoting the malignant progression of lung cancer cells. +other 35166006 hsa-mir-34 Nerve Degeneration Reduced Utx activity enhanced neurodegeneration and mimicked the protein accumulation seen in miR-34 mutant brains. +other 35165827 hsa-mir-361 Myocardial Infarction 3p. +transcription factor target 35165827 hsa-mir-361 Heart Diseases This study revealed that miR3p has a cardioprotective effect on hypoxia-induced cardiomyocyte injury, suggesting it may be a novel therapeutic target for hypoxia-related cardiac diseases. +genetics_knock down_suppress 35165827 hsa-mir-361 Hypoxia 3p overexpression markedly reduced hypoxia-induced cardiomyocyte injury; however, its downregulation had an opposite effect. +transcription factor target 35165519 hsa-mir-193a Carcinoma, Hepatocellular These findings revealed an important role of Mig-6 in the apoptosis and autophagy of HCC cells by regulating miR-193a-3p, providing a novel insight into the therapeutic target in HCC. +transcription factor target 35165511 hsa-mir-25 Carcinoma, Hepatocellular Therefore, miR-25 may represent a novel therapeutic target for the treatment of HCC. +other 35165388 hsa-mir-192 non-alcoholic steatohepatitis Overall, our data highlights the central role of Dicer-associated miR3p in the etiopathogenesis of macrophage M1 polarization in NASH and HCC. +other 35165388 hsa-mir-192 Carcinoma, Hepatocellular Overall, our data highlights the central role of Dicer-associated miR3p in the etiopathogenesis of macrophage M1 polarization in NASH and HCC. +virus_miRNA 35165282 ebv-mir-BART17 stomach carcinoma EBV-miR-BART11 and EBV-miR-BART17-3p upregulate the expression of PD-L1 in EBV-associated NPC and GC. +virus_miRNA 35165282 ebv-mir-BART11 stomach carcinoma EBV-miR-BART11 and EBV-miR-BART17-3p upregulate the expression of PD-L1 in EBV-associated NPC and GC. +virus_miRNA 35165282 ebv-mir-BART17 Nasopharyngeal Carcinoma EBV-miR-BART11 and EBV-miR-BART17-3p upregulate the expression of PD-L1 in EBV-associated NPC and GC. +virus_miRNA 35165282 ebv-mir-BART11 Nasopharyngeal Carcinoma EBV-miR-BART11 and EBV-miR-BART17-3p upregulate the expression of PD-L1 in EBV-associated NPC and GC. +genetics_overexpression_promote 35165280 hsa-mir-652 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma In our previous studies, we found that overexpression of the ARRB1-derived miR-223 sponge repressed T-ALL progress and reduced the expression of miR +genetics_knock down_promote 35164998 hsa-mir-155 psoriasis 1 mediated regulation of glycolysis, changes in glycolysis were assessed in psoriatic MSC (PM) with either overexpression or knockdown of TP53INP1, or activation/inhibition of p53 signaling pathway. +genetics_overexpression_promote 35164979 hsa-mir-345 Lymphoma, Large B-Cell, Diffuse RESULTS: Silencing of lncRNA NORAD and overexpression of miR +lncRNA target 35164915 hsa-mir-1226 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: miR-1226, which was regulated by ASCL1, inhibited tumor growth and migration by targeting FGF2, indicating that the ASCL1/miR-1226/FGF2 axis could be a potential therapeutic target for NSCLC. +genetics_overexpression_suppress 35164763 hsa-mir-603 Breast Neoplasms Also, the repressive effects of miR-603 mimic on the malignant behaviors of BC cells were weakened by KIF2A overexpression. +genetics_overexpression_promote 35164743 hsa-mir-378c gastric adenocarcinoma Furthermore, it was validated that miR-378c inhibition accelerated STAD cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT), while they were suppressed by miR-378c overexpression. +other 35164656 hsa-mir-1298 Arthritis, Rheumatoid The results illustrated the biological mechanism of OSER1-AS1/miR59/E2F1 axis in RA progression. +genetics_knock down_suppress 35164653 hsa-mir-141 Adenocarcinoma of Lung 3p inhibitor partly abolished the FAM83A-AS1 knockdown-induced inhibition on EMT, cell growth, invasion and migration in LUAD cells. +lncRNA target 35164634 hsa-mir-7 Cognition Disorders Decreased MEG3 alleviates cognitive dysfunction caused by ISO by targeting miR +lncRNA target 35164480 hsa-mir-939 Inflammatory Bowel Diseases Therefore, from the experimental results, it can be concluded that using miR-939 and miR-376a to trap NF-kappaB and NFAT inhibits the activation of transcription factors NF-kappaB and NFAT, which in turn inhibits the expression of inflammatory factors and results in partial recovery of the intestinal barrier in UC. +lncRNA target 35164480 hsa-mir-376a Inflammatory Bowel Diseases Therefore, from the experimental results, it can be concluded that using miR-939 and miR-376a to trap NF-kappaB and NFAT inhibits the activation of transcription factors NF-kappaB and NFAT, which in turn inhibits the expression of inflammatory factors and results in partial recovery of the intestinal barrier in UC. +lncRNA target 35163809 hsa-mir-760 cone-rod dystrophy 6 CK2alpha pathway plays essential roles in senescence and CR, thereby suggesting that KCNQ1OT1 is a novel therapeutic target for an alternative treatment that mimics the effects of anti-aging and CR. +circRNA target 35163797 hsa-mir-10391 Influenza, Human The results of this study suggested that TCONS_00166432 and novel_circ_0004733 could competitively bind miR-10391 to target the MAN2A1 gene to regulate swine influenza virus infecting 3D4/21 cells. +lncRNA target 35163786 hsa-mir-132 Inflammation 3p might participate in inflammation and PGE2 release via targeting DUSP9-dependent p38 and JNK signaling pathways to cause preterm birth. +lncRNA target 35163786 hsa-mir-132 Premature Birth 3p might participate in inflammation and PGE2 release via targeting DUSP9-dependent p38 and JNK signaling pathways to cause preterm birth. +transcription factor target 35163707 hsa-mir-196a Lung Neoplasms In this study, we found that miR-196a expression was greatly induced in gefitinib-resistant lung cancer cells. Our studies identified a new role and mechanism of NRF2/miR-196a/GLTP pathway in TKI resistance and lung tumor development, which may be used as a new biomarker (s) for TKI resistance or as a new therapeutic target in the future. +lncRNA target 35163556 hsa-mir-29a Carcinoma, Hepatocellular This study insight into a novel molecular pathway by which miR-29a targeting HIF-1alpha and ANGPT2 counteracts the incidence of HCC development. +epigenetics 35163224 hsa-mir-193a Ovarian Neoplasms Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM. We also identified three miRNA genes (MIR148A, MIR9-1, and MIR193A) that likely regulate EMT-MET reversion in the colonization of PMM. +epigenetics 35163224 hsa-mir-129-2 Ovarian Neoplasms Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM. +epigenetics 35163224 hsa-mir-339 Ovarian Neoplasms Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM. +epigenetics 35163224 hsa-mir-124 Ovarian Neoplasms Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM. +epigenetics 35163224 hsa-mir-107 Ovarian Neoplasms Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM. +epigenetics 35163224 hsa-mir-137 Ovarian Neoplasms Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM. +epigenetics 35163224 hsa-mir-127 Ovarian Neoplasms Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM. +epigenetics 35163224 hsa-mir-34b Ovarian Neoplasms Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM. +epigenetics 35163224 hsa-mir-132 Ovarian Neoplasms Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM. +epigenetics 35163224 hsa-mir-1258 Ovarian Neoplasms Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM. +epigenetics 35163224 hsa-mir-34c Ovarian Neoplasms Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM. +epigenetics 35163224 hsa-mir-125b-1 Ovarian Neoplasms Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM. +epigenetics 35163224 hsa-mir-148a Ovarian Neoplasms Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM. We also identified three miRNA genes (MIR148A, MIR9-1, and MIR193A) that likely regulate EMT-MET reversion in the colonization of PMM. +epigenetics 35163224 hsa-mir-9-1 Ovarian Neoplasms Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM. According to the Kaplan-Meier analysis, hypermethylation of several examined miRNA genes was associated with poorer overall survival of OvCa patients, and high methylation levels of MIR130B and MIR9-1 were related to the greatest relative risk of death. +epigenetics 35163224 hsa-mir-375 Ovarian Neoplasms Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM. +epigenetics 35163224 hsa-mir-124-2 Ovarian Neoplasms Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM. +epigenetics 35163224 hsa-mir-130b Ovarian Neoplasms Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM. According to the Kaplan-Meier analysis, hypermethylation of several examined miRNA genes was associated with poorer overall survival of OvCa patients, and high methylation levels of MIR130B and MIR9-1 were related to the greatest relative risk of death. +epigenetics 35163224 hsa-mir-9 Ovarian Neoplasms Thirteen miRNA genes (MIR107, MIR124-2, MIR124-3, MIR125B-1, MIR127, MIR129-2, MIR130B, MIR132, MIR193A, MIR339, MIR34B/C, MIR9-1, and MIR9-3) were hypermethylated already at the early stages of OvCa, while hypermethylation of MIR1258, MIR137, MIR203A, and MIR375 was pronounced in metastatic tumors, and MIR148A showed high methylation levels specifically in PMM. +exosome 35163219 hsa-mir-26a Prostatic Neoplasms Additionally, transcriptomic profiling of PCa-EVs revealed the abundance of three microRNAs, miR-26a-5p, miR-27a-3p, and miR-30e-5p involved in the suppression of BMPinduced osteogenesis in vivo, suggesting the critical role of these EV-derived miRNAs in PCa-mediated suppression of osteoblast activity. +exosome 35163219 hsa-mir-27a Prostatic Neoplasms Additionally, transcriptomic profiling of PCa-EVs revealed the abundance of three microRNAs, miR-26a-5p, miR-27a-3p, and miR-30e-5p involved in the suppression of BMPinduced osteogenesis in vivo, suggesting the critical role of these EV-derived miRNAs in PCa-mediated suppression of osteoblast activity. +lncRNA target 35163214 hsa-mir-425 Depressive Disorder, Major Overall, this systematic review presented a list of dysregulated cimiRNAs in MDD, notably miR +lncRNA target 35163214 hsa-mir-132 Depressive Disorder, Major Overall, this systematic review presented a list of dysregulated cimiRNAs in MDD, notably miR +lncRNA target 35163214 hsa-mir-135a Depressive Disorder, Major Overall, this systematic review presented a list of dysregulated cimiRNAs in MDD, notably miR +lncRNA target 35163214 hsa-mir-16 Depressive Disorder, Major Overall, this systematic review presented a list of dysregulated cimiRNAs in MDD, notably miR +lncRNA target 35163214 hsa-mir-26a Depressive Disorder, Major Overall, this systematic review presented a list of dysregulated cimiRNAs in MDD, notably miR +lncRNA target 35163214 hsa-mir-24 Depressive Disorder, Major Overall, this systematic review presented a list of dysregulated cimiRNAs in MDD, notably miR +lncRNA target 35163214 hsa-mir-124 Depressive Disorder, Major Overall, this systematic review presented a list of dysregulated cimiRNAs in MDD, notably miR +lncRNA target 35163214 hsa-let-7a Depressive Disorder, Major Overall, this systematic review presented a list of dysregulated cimiRNAs in MDD, notably miR +other 35163198 hsa-mir-21 Carcinoma, Pancreatic Ductal In this study, we investigated the role of miR-21, which is highly expressed in Panc-1 and MiaPaCa-2 PDAC cells in association with CSCs. Our data suggest that miR-21 is involved in the stemness of PDAC cells, may play roles in mesenchymal transition, and that miR-21 poses as a novel, functional biomarker for PDAC aggressiveness. +other 35163102 hsa-mir-1 Sveinsson Chorioretinal Atrophy Muscle-miRNAs (miR-1, -133, -206 and -499) were up-regulated, especially in AA samples, and we identified molecular networks with omics integration. +other 35163102 hsa-mir-338 Sveinsson Chorioretinal Atrophy Two pairs of genes and miRNAs demonstrated a high-level relationship, and involvement in myogenesis and muscle growth: marcksb and miR-29b in AA, and mmp14b and miR5p in IGF1. +other 35163102 hsa-mir-29b Sveinsson Chorioretinal Atrophy Two pairs of genes and miRNAs demonstrated a high-level relationship, and involvement in myogenesis and muscle growth: marcksb and miR-29b in AA, and mmp14b and miR5p in IGF1. +lncRNA target 35163020 hsa-mir-150 Vascular Diseases 5p expression and counteracts the inhibitory effect of miR +transcription factor target 35162959 hsa-mir-16 Heart Diseases We also find that, in response to tunicamycin-induced ER stress, miR5p suppression decreases apoptosis, inflammation and cardiac damage via activating the ATF6-mediated cytoprotective pathway. +circulation_biomarker_diagnosis_ns 35162959 hsa-mir-16 Dmd-Associated Dilated Cardiomyopathy Previously, we demonstrated that miR5p is enriched in the plasma of ischemic dilated cardiomyopathy (ICM) patients and promotes ER stress-induced apoptosis in cardiomyocytes in vitro. +transcription factor target 35162959 hsa-mir-16 Heart Injuries 5p might contribute to oxidative stress through ER stress induction and that targeting miR +genetics_overexpression_promote 35162959 hsa-mir-16 Dehydration 5p overexpression promotes oxidative stress in AC16 cardiomyoblasts. +circulation_biomarker_diagnosis_up 35162959 hsa-mir-16 Glycogen Storage Disease Type VI 5p is enriched in the plasma of ischemic dilated cardiomyopathy (ICM) patients and promotes ER stress-induced apoptosis in cardiomyocytes in vitro. +circulation_biomarker_diagnosis_up 35160300 hsa-mir-223 Instent Restenosis CONCLUSION: Elevated serum level of miRNA-223 might be helpful in predicting the occurrence of ISR. +other 35160257 hsa-mir-511 Head and Neck Neoplasms 3p may be a useful biomarker of nutritional deficiencies in patients subjected to IMRT due to HNC. +circulation_biomarker_diagnosis_ns 35160116 hsa-let-7a Carcinoma, Non-Small-Cell Lung In NSCLC patients, lower miR let-7a expression level was observed in tumor tissue compared to serum; however, miR-335 expression level was higher (p < 0.05). Changes in miR-335 and miR let-7a expression levels in the serum exosomes of NSCLC patients in relation to lymph node metastases and tumor stage may serve as a non-invasive molecular biomarker of tumor progression. +circulation_biomarker_diagnosis_ns 35160116 hsa-mir-335 Carcinoma, Non-Small-Cell Lung In NSCLC patients, lower miR let-7a expression level was observed in tumor tissue compared to serum; however, miR-335 expression level was higher (p < 0.05). Changes in miR-335 and miR let-7a expression levels in the serum exosomes of NSCLC patients in relation to lymph node metastases and tumor stage may serve as a non-invasive molecular biomarker of tumor progression. +circulation_biomarker_diagnosis_ns 35159951 hsa-mir-451a Malaria Circulating exosomal miR-451a and let-7i-5p were lower in HbSS+. miR-451a and let-7i-5p modulate genes involved in inflammation, making them potential biomarkers of pathogenesis for both diseases. +circulation_biomarker_diagnosis_ns 35159951 hsa-mir-451a Anemia, Sickle Cell Circulating exosomal miR-451a and let-7i-5p were lower in HbSS+. miR-451a and let-7i-5p modulate genes involved in inflammation, making them potential biomarkers of pathogenesis for both diseases. +circulation_biomarker_diagnosis_ns 35159951 hsa-let-7i Malaria Circulating exosomal miR-451a and let-7i-5p were lower in HbSS+. miR-451a and let-7i-5p modulate genes involved in inflammation, making them potential biomarkers of pathogenesis for both diseases. +circulation_biomarker_diagnosis_ns 35159951 hsa-let-7i Anemia, Sickle Cell Circulating exosomal miR-451a and let-7i-5p were lower in HbSS+. miR-451a and let-7i-5p modulate genes involved in inflammation, making them potential biomarkers of pathogenesis for both diseases. +other 35159373 hsa-mir-21 Pulmonary Arterial Hypertension Collectively, our study revealed that the upregulation of miR-21 in the early phase (RV hypertrophy) and downregulation in the late phase (RV dysfunction) under PAH triggered a biphasic regulation of cardiac remodeling and cardiomyocyte apoptosis. +other 35159373 hsa-mir-21 Ventricular Dysfunction, Right Collectively, our study revealed that the upregulation of miR-21 in the early phase (RV hypertrophy) and downregulation in the late phase (RV dysfunction) under PAH triggered a biphasic regulation of cardiac remodeling and cardiomyocyte apoptosis. +lncRNA target 35159335 hsa-mir-146a Pulmonary Disease, Chronic Obstructive 5p and miR-146a-5p may be involved in CMH via fibroblasts-epithelium crosstalk, including extracellular matrix gene regulation, while airway epithelial expression of miR +lncRNA target 35159335 hsa-let-7a Pulmonary Disease, Chronic Obstructive 5p and miR-146a-5p may be involved in CMH via fibroblasts-epithelium crosstalk, including extracellular matrix gene regulation, while airway epithelial expression of miR +lncRNA target 35159335 hsa-mir-1 Pulmonary Disease, Chronic Obstructive 5p and miR-146a-5p may be involved in CMH via fibroblasts-epithelium crosstalk, including extracellular matrix gene regulation, while airway epithelial expression of miR +lncRNA target 35159335 hsa-mir-708 Pulmonary Disease, Chronic Obstructive 5p and miR-146a-5p may be involved in CMH via fibroblasts-epithelium crosstalk, including extracellular matrix gene regulation, while airway epithelial expression of miR +lncRNA target 35159261 hsa-mir-100 Lipoma Previously, microRNA-100 (miR-100) and its putative mRNA target, insulin-like growth factor receptor-1 (IGF1R) were identified as differentially and inversely expressed in bovine longissimus dorsi (LD) muscles with divergent intramuscular fat (IMF) content by our group. +genetics_overexpression_promote 35159062 hsa-mir-21 Carcinoma, Renal Cell First, in a cohort of 52 primary ccRCC samples, using RT-qPCR and immunohistochemistry, we showed that miR-21 overexpression was correlated with PPAR-alpha downregulation. +other 35159038 hsa-mir-151a Adenocarcinoma of Lung We specifically investigated an edited miRNA, miR-151a-3p with an A-to-I editing event at position 3, to determine how its altered expression may be associated with activation of divergent biological pathways between W and B/AA LUAD patients. +other 35159038 hsa-mir-151a Lung Neoplasms We specifically investigated an edited miRNA, miR-151a-3p with an A-to-I editing event at position 3, to determine how its altered expression may be associated with activation of divergent biological pathways between W and B/AA LUAD patients. +other 35158368 hsa-mir-21 Choroidal Neovascularization CONCLUSION: miR-21 correlated with HIF-1alpha-VEGF signaling pathway may promote CNV formation in high-myopia guinea. +circulation_biomarker_diagnosis_up 35158353 hsa-mir-145 Diabetes Mellitus, Type 2 3p in the serum of T2DM patients, was found in this study. +circulation_biomarker_diagnosis_up 35158353 hsa-mir-101 Albuminuria 3p in the serum of T2DM patients, was found in this study. +circulation_biomarker_diagnosis_up 35158353 hsa-mir-101 Diabetes Mellitus, Type 2 3p in the serum of T2DM patients, was found in this study. +circulation_biomarker_diagnosis_up 35158353 hsa-mir-874 Diabetes Mellitus, Type 2 3p in the serum of T2DM patients, was found in this study. +circulation_biomarker_diagnosis_up 35158353 hsa-mir-145 Albuminuria 3p in the serum of T2DM patients, was found in this study. +circulation_biomarker_diagnosis_up 35158353 hsa-mir-874 Albuminuria 3p in the serum of T2DM patients, was found in this study. +circulation_biomarker_diagnosis_ns 35157730 hsa-mir-192 Hepatitis B, Chronic The serum miR5p level was useful as a biomarker for the therapeutic efficacy of Peg-IFN in CHB treatment. +circulation_biomarker_diagnosis_up 35157721 hsa-mir-21 Carcinoma, Hepatocellular Conclusion: Plasma biomarkers: miRNA-21 and miRNA-155 might be potential biomarkers as onco-miR in HCC subjects, while miRNA-29c might act as a tumor suppressor. +circulation_biomarker_diagnosis_up 35157721 hsa-mir-29c Carcinoma, Hepatocellular Conclusion: Plasma biomarkers: miRNA-21 and miRNA-155 might be potential biomarkers as onco-miR in HCC subjects, while miRNA-29c might act as a tumor suppressor. +circulation_biomarker_diagnosis_up 35157721 hsa-mir-155 Carcinoma, Hepatocellular Conclusion: Plasma biomarkers: miRNA-21 and miRNA-155 might be potential biomarkers as onco-miR in HCC subjects, while miRNA-29c might act as a tumor suppressor. +genetics_knock down_promote 35157222 hsa-mir-155 Acute Lung Injury Whether miR-155/SOCS1 axis could regulate the acute lung injury caused by C. Knockdown of miR-155 improved the acute lung injury, suppressed inflammatory factors and fungus loading through SOCS1. +other 35157005 hsa-mir-182 Cholangiocarcinoma 5p, and miR-92a-3p was significantly higher in detached cell samples from smears of cholangiocarcinoma cases than in those from noncancer cases. +other 35157005 hsa-mir-1 Cholangiocarcinoma 5p, and miR-92a-3p was significantly higher in detached cell samples from smears of cholangiocarcinoma cases than in those from noncancer cases. +other 35157005 hsa-mir-92a Cholangiocarcinoma 5p, and miR-92a-3p was significantly higher in detached cell samples from smears of cholangiocarcinoma cases than in those from noncancer cases. +lncRNA target 35156900 hsa-mir-197 Adenocarcinoma of Lung In summary, this research demonstrated that circular RNA circMMD_007 could promote the oncogenic effects in the progression of LC through miR3p/PTPN9 axis. +circulation_biomarker_diagnosis_down 35156897 hsa-mir-885 Asthma 3p expression in acute asthma patients' plasma was significantly downregulated. +circulation_biomarker_diagnosis_up 35156729 hsa-mir-182 Coronary Artery Disease 5p, and TLN1 in the serum samples of CAD and non-CAD individuals was assessed via a real-time quantitative polymerase chain reaction. +circulation_biomarker_diagnosis_up 35156729 hsa-mir-9 Coronary Artery Disease 5p, and TLN1 in the serum samples of CAD and non-CAD individuals was assessed via a real-time quantitative polymerase chain reaction. +other 35156543 hsa-mir-484 Colorectal Neoplasms Also, DLK1 silencing reversed the effects of downregulated miR-484 on migration, invasion, sphere formation, and CSC molecules expressions in CRC cells. +circulation_biomarker_diagnosis_ns 35156517 hsa-mir-23a Sepsis, Intensive Care Unit-Acquired Rs12196996 GG and rs2232365 AA were also correlated with increased level of miR-23a, IL-10 and decreased level of TNF, IL-2, IFN, IL-6 and IL-1beta in the peripheral blood cell samples of patients with ICU-acquired sepsis. +lncRNA target 35156516 hsa-mir-664b Colonic Neoplasms The study indicated that miR-664b-3p plays a significant role in colon cancer and could regulate the progression of colon cancer tumor growth by suppressing the expression of BUB3 protein. +lncRNA target 35156514 hsa-let-7a Liver Neoplasms Therefore, LncRNA RSU1P2 promotes tumorigenesis and cancer stem cell-like properties in liver cancer through let-7a/Tex10 pathway. +genetics_overexpression_promote 35156513 hsa-mir-656 Melanoma Rescue assays indicated that miR-656 overexpression inhibited the aforementioned cellular activities in melanoma cells, which were reversed by SERBP1 overexpression. +exosome 35156510 hsa-mir-154 Esophageal Squamous Cell Carcinoma In conclusion, our study identified that exosomes-derived miR +lncRNA target 35156509 hsa-mir-138 Esophageal Squamous Cell Carcinoma Taken together, this study for the first time demonstrates that upregulation of lncRNA TRPM2-AS in EC promotes the growth and metastasis of EC likely through interacting with miR-1291, miR +lncRNA target 35156509 hsa-mir-1291 Esophageal Squamous Cell Carcinoma Taken together, this study for the first time demonstrates that upregulation of lncRNA TRPM2-AS in EC promotes the growth and metastasis of EC likely through interacting with miR-1291, miR +lncRNA target 35156509 hsa-mir-6852 Esophageal Squamous Cell Carcinoma Taken together, this study for the first time demonstrates that upregulation of lncRNA TRPM2-AS in EC promotes the growth and metastasis of EC likely through interacting with miR-1291, miR +lncRNA target 35156508 hsa-mir-339 Glioma 3p/IP6K2 regulatory axis might be a potential therapeutic target for glioma. +genetics_knock down_suppress 35156507 hsa-mir-18b Squamous Cell Carcinoma of Head and Neck However, inhibiting miR-18b-5p or overexpression of Y-box protein 2 (YBX2) can reverse the effect of circ-CLK1 knockdown on OSCC cells. Therefore, circ-CLK1 inhibited the apoptosis of OSCC cells through the miR-18b-5p/YBX2 axis, and these findings suggest that circ-CLK1 could be a potential therapeutic target for OSCC patients. +exosome 35156506 hsa-mir-15b Laryngeal Neoplasms Overall, tumor-derived exosomal miR-15b-5p augments LCa through targeting down-regulation of TXNIP. +genetics_overexpression_promote 35156481 hsa-mir-497 Uterine Cervical Neoplasms 5p was at low level in human CC cell lines, while FASN was overexpressed and demonstrated as a target of miR +other 35156321 hsa-mir-145 Melanoma Upregulation of the miR-143/-145 cluster under BRAFi/MAPKi therapy was observed in melanoma cells in vitro and in vivo and was associated with an invasive/undifferentiated profile. +genetics_knock down_promote 35156240 hsa-mir-650 Carcinoma, Hepatocellular Moreover, miR-650 down-regulation or TIMP3 up-regulation reversed the effects of lncRNA NBR2 knockdown that caused an enhancement of cell viability, migration and invasiveness in remifentanil-treated HCC cells. +exosome 35155688 hsa-mir-22 Alopecia CONCLUSION: ADSC-Exos therapy positively affected the promotion of hair regrowth by regulating miR-22, the Wnt/beta-catenin signaling pathway, and the TNF-alpha signaling pathway, implying that ADSC-Exos could be a promising cell-free therapeutic strategy for immune-mediated alopecia. +lncRNA target 35155576 hsa-mir-135b Diabetic Cardiomyopathies Ranolazine treatment of diabetic cardiac fibrosis inhibited pyroptosis and collagen deposition by upregulating miR-135b. +virus_miRNA 35155300 hsv1-mir-H9 Prostatic Neoplasms Expression of hsv1-miR-H18 and hsv2-miR-H9 was significantly higher in primary tumors from PCa patients than in BPH controls (P < 0.0001). +virus_miRNA 35155300 hsv1-mir-H18 Prostatic Neoplasms Expression of hsv1-miR-H18 and hsv2-miR-H9 was significantly higher in primary tumors from PCa patients than in BPH controls (P < 0.0001). +other 35155200 hsa-mir-145 gastric adenocarcinoma After performing bioinformatics analysis, the CCDC144NL-AS1/hsa-miR5p/SERPINE1 ceRNA network associated to STAD prognosis of STAD was obtained. +target gene 35154537 hsa-mir-524 Thyroid Neoplasms Ginsenoside Rh2 inhibits thyroid cancer cell migration and proliferation via activation of miR-524-5p. +other 35154526 hsa-mir-499b Carcinoma, Hepatocellular There was a significant association between rs10061133 miR-499b and the risk of HCC. +circRNA target 35154515 hsa-mir-326 Urinary Bladder Neoplasms CONCLUSION: hsa_circ_0139402 plays a oncogene in BC and that can effectively promote cell proliferation, migration, invasion, and EMT by targeting Paired Box Protein Pax-8 (PAX8) via hsa-miR-326 and provides a potential therapeutic target for BC patients. +target gene 35154460 hsa-mir-506 Ovarian Neoplasms MicroRNA-506-3p inhibits ovarian cancer metastasis by down-regulating the expression of EZH2. +genetics_overexpression_promote 35154459 hsa-mir-17 Colorectal Neoplasms Overexpression of miR +target gene 35154447 hsa-mir-181 Lymphoma, Large B-Cell, Diffuse LncRNA SNHG5 can Regulate the Proliferation and Migration of Diffuse Large B Cell Lymphoma Progression via Targeting miR-181-5p/XIAP. +lncRNA target 35154444 hsa-mir-363 Colorectal Neoplasms 3p/GALNT7 axis exerts on key roles in cell proliferation and presents an emerging target for CRC therapy and prognostic biomarker. +transcription factor target 35154347 hsa-mir-24 Myocardial Ischemia In addition, the study explored the possible mechanism through which SYD could reduce myocardial ischemia apoptosis and regulate the expression of the miR-24/Bim pathway. +circulation_biomarker_diagnosis_up 35154347 hsa-mir-24 Chorea These cardiomyocytes were transfected with an miR-24 mimic and an miR-24 inhibitor and then cocultured with SYD-containing serum. +other 35154259 hsa-mir-1299 Ovarian Neoplasms Our findings interpret the underlying mechanisms of the CDR1as/miR-1299/PPP1R12B axis and shed light on the clinical applications for CDDP-chemoresistant OC. +target gene 35154253 hsa-mir-378a Osteosarcoma Hypoxia-Induced miR-378a-3p Inhibits Osteosarcoma Invasion and Epithelial-to-Mesenchymal Transition via BYSL Regulation. +other 35154084 hsa-mir-133 Lichen Sclerosus et Atrophicus In this study, we showed that the expression of miR-133 was significantly up-regulated in the mud crab Scylla paramamosain after infection by white spot syndrome virus (WSSV) or Vibrio parahaemolyticus. +genetics_knock down_promote 35154084 hsa-mir-133 Werner Syndrome miR-133 Knockdown enhanced the apoptosis or phagocytosis of crab hemocytes, and increased the mortality of mud crabs after WSSV or V. +other 35153496 hsa-mir-132 Diabetic Retinopathy RESULTS: We observed that levels of miR-126 and miR-132 were decreased in NPDR subjects in comparison to DNR. +circulation_biomarker_diagnosis_ns 35153496 hsa-mir-126 Diabetic Retinopathy CONCLUSION: Circulating miRs 126 and 132 in plasma or vitreous may serve as biomarkers for early diabetic retinopathy risk prediction, provided validated in a larger cohort and other forms of retinal vasculopathy or retinopathy in the future. +circulation_biomarker_diagnosis_up 35152853 hsa-mir-148b Osteosarcoma miR-148b-3p mimic or inhibitor, pcDH-SOS1 plasmid or si-SOS1 and agomir-miR-148b-3p were constructed for cell transfection. +lncRNA target 35152842 hsa-mir-486 Precursor Cell Lymphoblastic Leukemia-Lymphoma Altogether, silencing of PVT1 inhibited ALL cell growth and induced cell apoptosis through sponging miR +circRNA target 35152839 hsa-mir-449a Uterine Cervical Neoplasms The circCDK6 participated in tumorigenesis and cancer progression and might serve as a tumor suppressive factor in cervical cell progression via Epithelial-MesenchymalTransition (EMT) process by regulating miR-449a. +lncRNA target 35152838 hsa-mir-641 Breast Neoplasms In conclusion, LINC00665 could promote the survival and metastasis of breast cancer cells through sponging miR-641 and targeting SRCAP. +other 35152718 hsa-mir-190 Aortic Valve Insufficiency Results: miR-136, miR-208 and miR-190 were upregulated in the AR group. +other 35152718 hsa-mir-136 Aortic Valve Insufficiency Results: miR-136, miR-208 and miR-190 were upregulated in the AR group. +other 35152718 hsa-mir-208 Aortic Valve Insufficiency Results: miR-136, miR-208 and miR-190 were upregulated in the AR group. +lncRNA target 35152537 hsa-mir-495 Cardiotoxicity 3p as an endogenous protectant against Dox-induced cardiotoxicity through activating AKT pathway in vivo and in vitro. +genetics_overexpression_promote 35152529 hsa-mir-203a Squamous Cell Carcinoma of Head and Neck Transwell assays showed that invasion and migration of OSCC cells were enhanced by HOXD-AS1 and Annexin A4 overexpression but were reduced by miR-203a-5p overexpression. +genetics_overexpression_promote 35152215 hsa-mir-769 Osteosarcoma 5p upregulation accelerated the viability and mobility of osteosarcoma cells, which can be blocked by RARRES1 overexpression. +lncRNA target 35151688 hsa-mir-673 Tuberous Sclerosis 5p targets the regulator of mechanistic target of the rapamycin (mTOR) complex 1 (mTORC1) tuberous sclerosis complex 2 in SCs, leading to the activation of downstream signaling pathways including mTORC1 and sterol-regulatory element binding protein 2. +lncRNA target 35151575 hsa-mir-339 Polycystic Ovary Syndrome 5p inhibitor group had higher protein expressions of PI3K, AKT and SIRT1 but lower expression of PGC-1alpha in PCOS patients (P < 0.001, P=0.030, P=0.047, P=0.003). +other 35151325 hsa-mir-338 Osteosarcoma Further, in association with immune cell infiltration, hsa-circ-0010220, hsa-miR-326, hsa-miR3p, and FAM98A were identified as potential novel biomarkers for OS diagnosis. +other 35151325 hsa-mir-326 Osteosarcoma Further, in association with immune cell infiltration, hsa-circ-0010220, hsa-miR-326, hsa-miR3p, and FAM98A were identified as potential novel biomarkers for OS diagnosis. +other 35151110 hsa-mir-125b Celiac Disease 5p and miR-125b-5p (alone or in combination), were able to discriminate these three groups with high accuracy and specificity. +other 35151110 hsa-mir-192 Celiac Disease 5p and miR-125b-5p (alone or in combination), were able to discriminate these three groups with high accuracy and specificity. +other 35151110 hsa-mir-215 Celiac Disease 5p and miR-125b-5p (alone or in combination), were able to discriminate these three groups with high accuracy and specificity. +other 35150890 hsa-mir-485 Tuberculosis, Pulmonary "5p, SLC23A2, pyridoxal phosphate, pyridoxamine phosphate, and folic acid may collectively constitute the ""integrative pattern"" of multiple biomarkers, which may provide an accurate diagnosis of TB." +transcription factor target 35150797 hsa-mir-9 Genital Diseases, Male In summary, the present study highlights the role of the SC-Exo/miR3p/StAR signaling pathway in PFOS-induced suppression of testosterone biosynthesis, advancing our understanding of molecular mechanisms for PFOS-induced male reproductive disorders. +genetics_overexpression_promote 35150479 hsa-mir-212 Alzheimer Disease 3p overexpression was linked to improved learning and memory capacities of AD rats and reduced neuronal pyroptosis linked to neuroinflammation attenuation. +genetics_overexpression_promote 35150405 hsa-mir-139 Carcinoma, Non-Small-Cell Lung 3p on the LUSC cell phenotypes could be blocked by overexpressing CHEK1. +circulation_biomarker_diagnosis_up 35150402 hsa-mir-181b Carcinoma, Non-Small-Cell Lung RESULTS: We demonstrated that miR-181b was up-regulated in exosomes derived from NSCLC patients' serum and NSCLC cells. +epigenetics 35149775 hsa-mir-152 Heart Failure 3p by promoting the methylation of miR +lncRNA target 35149732 hsa-mir-520a Lung Neoplasms Targeting miR-520a-5p could be an approach to restoring FZD9 expression and improving response to iloprost lung cancer chemoprevention. +lncRNA target 35149697 hsa-mir-200a Carcinoma, Ovarian Epithelial Therefore, the SNHG10/miR-200a-3p/BIN1 axis may act as a potential predictive biomarker and therapeutic target for treating EOC. +lncRNA target 35149188 hsa-mir-24 Cardiomyopathies 3p contributes to the reduction of cardiac fibrosis and that it might be targeted therapeutically to alleviate cardiac fibrosis. +genetics_overexpression_promote 35148687 hsa-mir-18a Osteoarthritis MiR-18a-3p overexpression suppressed OA progression in vivo. +genetics_knock down_suppress 35148669 hsa-mir-338 Sepsis In sum, our results elaborated that circHIPK3 knockdown attenuated LPS-triggered HK2 cell injury by regulating FOXA1 expression via interacting with miR-338, suggesting that circHIPK3 might be a potential biomarker and therapeutic target for sepsis-induced AKI patients. +genetics_knock down_suppress 35148669 hsa-mir-338 Acute Kidney Injury In sum, our results elaborated that circHIPK3 knockdown attenuated LPS-triggered HK2 cell injury by regulating FOXA1 expression via interacting with miR-338, suggesting that circHIPK3 might be a potential biomarker and therapeutic target for sepsis-induced AKI patients. +transcription factor target 35148667 hsa-mir-135a Heart Diseases Moreover, over-expression of miR-135a-5p resulted in inhibition of inflammatory infiltration and almost eliminated cardiac fibrosis, as evidenced by decreased Collagen (COL)-I, COL-III, a-smooth muscle actin, NLRP3, tumor necrosis factor-alpha, and interleukin-6. Collectively, our findings indicated that miR-135a-5p over-expression inhibited TXNIP expression to block the binding of TXNIP and NLRP3, thereby alleviating hypertensive cardiac inflammation and fibrosis. +transcription factor target 35148667 hsa-mir-135a Diabetic Nephropathies Moreover, over-expression of miR-135a-5p resulted in inhibition of inflammatory infiltration and almost eliminated cardiac fibrosis, as evidenced by decreased Collagen (COL)-I, COL-III, a-smooth muscle actin, NLRP3, tumor necrosis factor-alpha, and interleukin-6. Collectively, our findings indicated that miR-135a-5p over-expression inhibited TXNIP expression to block the binding of TXNIP and NLRP3, thereby alleviating hypertensive cardiac inflammation and fibrosis. +lncRNA target 35148461 hsa-mir-99a Urinary Bladder Neoplasms In summary, tumor-suppressive miR-99a-5p induced cellular senescence in gemcitabine-resistant bladder cancer cells by targeting SMARCD1. +other 35147479 hsa-mir-216a Diabetic Nephropathies RESULTS: HbA1c, TGFbeta1, miR-217, and miR-224 in T2DM patients increased with UACR, while miR-192 and miR-216a decreased. +other 35147479 hsa-mir-192 Diabetic Nephropathies RESULTS: HbA1c, TGFbeta1, miR-217, and miR-224 in T2DM patients increased with UACR, while miR-192 and miR-216a decreased. +other 35147479 hsa-mir-217 Diabetic Nephropathies RESULTS: HbA1c, TGFbeta1, miR-217, and miR-224 in T2DM patients increased with UACR, while miR-192 and miR-216a decreased. +other 35147479 hsa-mir-224 Diabetic Nephropathies RESULTS: HbA1c, TGFbeta1, miR-217, and miR-224 in T2DM patients increased with UACR, while miR-192 and miR-216a decreased. +genetics_overexpression_promote 35147250 hsa-mir-146a Osteoarthritis Overexpression of miR-146a diminished the protective effects of melatonin by inhibiting NRF2 expression and aggravating OA-induced cartilage degradation. +transcription factor target 35146917 hsa-mir-129-2 Carcinoma, Non-Small-Cell Lung 2 can serve as a potential diagnostic and therapeutic target in NSCLC. +circulation_biomarker_diagnosis_up 35146790 hsa-mir-210 Varicocele Seminal plasma MIR210HG expression is upregulated in VC patients, is associated with the severity of VC and may function as an independent predictor of VC-related dyszoospermia. +circulation_biomarker_diagnosis_up 35146790 hsa-mir-210 Azoospermia Seminal plasma MIR210HG expression is upregulated in VC patients, is associated with the severity of VC and may function as an independent predictor of VC-related dyszoospermia. +other 35145966 hsa-mir-127 Breast Neoplasms 3p, RPL36 and RPL27A mRNAs. +other 35145966 hsa-mir-2114 Breast Neoplasms 3p, RPL36 and RPL27A mRNAs. +lncRNA target 35145900 hsa-mir-18a Carcinoma, Hepatocellular In Huh-7 (R) and HCCLM3 (R) cells, CASC2 affected cell proliferation through the miR-18a/RIPK1 axis and the NF-kappaB signaling. In conclusion, CASC2 affects cell growth mainly via the miR-24/caspase-8 and miR-221/caspase-3 axes in TRAIL-sensitive HCC cells; while in TRAIL-resistant HCC cells, CASC2 affects cell growth mainly via miR-18a/RIPK1 axis and the NF-kappaB signaling. +other 35145896 hsa-mir-126 Diabetes Mellitus Also, vitamin D3+ATRA can be considered a new therapeutic agent that can elevate miR-126 expression and prevent diabetes-related cardiovascular complications. +other 35145563 hsa-mir-4 Uterine Cervical Neoplasms 5p to regulate HMGB1. +other 35145542 hsa-mir-186 Carcinoma, Renal Cell Next, we successfully constructed a ceRNA network of two mRNA (NR3C2 and VAV3), miRNA (hsa-miR5p), and lncRNA (NNT-AS1) for ccRCC based on numerous online bioinformatics tools and Cytoscape. +other 35145534 hsa-mir-167 Li-Fraumeni Syndrome A new network of ceRNAs correlated with LF was constructed, and it consisted of one mRNA (PsTPS1), one lncRNA (TCLR, LTCONS_00034157), and one miRNA (miR167h). +other 35145514 hsa-mir-194 Graft vs Host Disease In the present study, we further investigated the role of the expression profile of membrane proteins and their microRNA (miRNA) cargo (miRNA100, miRNA155, and miRNA194) in predicting the onset of aGvHD in haploidentical transplant recipients with PT-Cy. This analysis showed that the combination of CD146, sTNFR1, and miR100 or miR194 strongly correlated with the onset of aGvHD (AUROC >0.975). +circulation_biomarker_prognosis_ns 35145164 hsa-mir-1290 Colorectal Neoplasms miR-1246 and miR-1290 levels were significantly higher in the plasma of patients with CRC than in the plasma of healthy controls (P < 0.05). The tissue expression of miR-200c-3p and plasma levels of miR-1290 measured by ddPCR indicate their potential as prognostic biomarkers for CRC. +target gene 35144475 hsa-mir-200c Wilms Tumor microRNA-200c-3p suppresses proliferation and invasion of nephroblastoma cells by targeting EP300 and inactivating the AKT/FOXO1/p27 pathway. +other 35144146 hsa-mir-721 Myocarditis Herein, we propose a generic and non-enzymatic electrochemical strategy integrated molecular beacon-like catalyzed hairpin assembly (mCHA) circuit with MOF@Au@G-triplex/hemin nanozyme for ultrasensitive detection of miR-721 (a novel diagnostic biomarker of acute myocarditis). The proposed biosensor has been successfully used in miR-721 detection in real biological samples, which provided a promising potential method for acute myocarditis early diagnosis. +lncRNA target 35144130 hsa-mir-223 Inflammation Then, the change of inflammatory injury and activation of NLRP3 inflammasomes in B(a)P-induced A549 cells were detected after inhibiting of GSDMD or miR-223 using siRNA-GSDMD (siGSDMD) or miR-223 inhibitor, respectively. +transcription factor target 35144130 hsa-mir-223 Gerstmann-Straussler-Scheinker Disease In conclusion, GSDMD may regulate NLRP3 inflammasome through miR-223, which is involved in B(a)P induced inflammatory damage in A549 cells. +transcription factor target 35144130 hsa-mir-223 Pneumonia However, whether GSDMD regulate NLRP3 inflammasome through miR-223 in B(a)P induced lung inflammatory injury remain unknown. +genetics_overexpression_promote 35143426 hsa-mir-20a Carcinoma, Hepatocellular RUNX3 was not only reduced in HCC specimens but also drastically reduced in HCC cells overexpressing miR-20a-5p. +genetics_overexpression_promote 35143103 hsa-mir-515 Colorectal Neoplasms 5p overexpression on the biological behaviors of CRC cells above. +lncRNA target 35143052 hsa-mir-513c Squamous Cell Carcinoma of Head and Neck These studies verified that CDK5 regulates the occurrence and development of TSCC cells through the microRNA 513c-5p/cell division cycle 25B pathway. In addition, the authors observed that CDK5 regulated the growth of TSCC through the microRNA 513c-5p/cell division cycle C25B pathway. +circRNA target 35142978 hsa-mir-520h Diabetic Nephropathies CONCLUSION: GEC-circTAOK1-Exo could boost proliferation, fibrosis, and EMT of GMC through targeting the miR-520h/SMAD3 axis, providing new insights into the pathogenesis of DN. +genetics_knock down_promote 35142935 hsa-mir-30 Squamous Cell Carcinoma of Head and Neck 3p partly reversed circ_0120175 knockdown-induced effects in LSCC cells. +lncRNA target 35142692 hsa-mir-101a Spinal Cord Ischemia These findings suggest that the miR-101a-3p mimic improved spinal ischemia/reperfusion injury-induced nerve cell apoptosis and inflammation by inhibiting MYCN and the p53 signaling pathway. Therefore, miR-101a-3p mimic therapy may be a potential treatment option for spinal ischemia/reperfusion injury. +genetics_knock down_promote 35142595 hsa-mir-136 Pancreatic Carcinoma Overall, DSCAM-AS1 knockdown inhibits pancreatic cancer progression by modulating the miR +circulation_biomarker_diagnosis_up 35142592 hsa-mir-29c Polycystic Ovary Syndrome PCOS rats were injected with plasmids vectors interfering with miR-29 c-3p or Foxo3 expression, respectively. +lncRNA target 35142579 hsa-mir-128-2 Pancreatitis 2-5p expression in the lung tissue, increased Tollip expression, inhibited HMGB1, TLR4, TRAF6, IRAK1, MyD88, NF-kappaB65, and p-IkappaB-alpha expression levels, suppressed NF-kappaB65 and the TLR4 expression levels, reduced MPO activity, reduced TNF-alpha, IL-1beta, IL-6, and ICAM-1 levels in BALF, and alleviated SAP-induced ALI. +lncRNA target 35142579 hsa-mir-128-2 Acute Lung Injury 2-5p expression in the lung tissue, increased Tollip expression, inhibited HMGB1, TLR4, TRAF6, IRAK1, MyD88, NF-kappaB65, and p-IkappaB-alpha expression levels, suppressed NF-kappaB65 and the TLR4 expression levels, reduced MPO activity, reduced TNF-alpha, IL-1beta, IL-6, and ICAM-1 levels in BALF, and alleviated SAP-induced ALI. +genetics_knock down_suppress 35142578 hsa-mir-24 Pneumonia Circ_0026579 knockdown alleviated LPS-induced WI-38 cells inflammation by miR3p/IGF2 axis, suggesting that circ_0026579 might contribute to infantile pneumonia progression. +circulation_biomarker_prognosis_ns 35141939 hsa-mir-21 Acute Lung Injury 3p in plasma are correlated with the severity and prognosis of ALI patients, and their combination has a high value for the prognostic assessment of ALI patients. +lncRNA target 35141790 hsa-mir-206 Non-alcoholic Fatty Liver Disease RMRP inhibition prevented NAFLD progression in rats via targeting the miR-206/PTPN1 axis. +other 35141302 hsa-mir-490 Atrial Fibrillation 3p/LRRC2 network based on ceRNA theory in AF in the bioinformatic analyses of public datasets. +circRNA target 35141166 hsa-mir-31 Enterovirus B, Human In conclusion, this study found that circSIAE can target TAOK2 through sponge adsorption of miR +lncRNA target 35141164 hsa-mir-497 Pancreatic Carcinoma Rescue experiments demonstrated that the effects of SNHG1 downregulation on PC cells were attenuated when simultaneously inhibiting the levels of miR-497. CONCLUSIONS: SNHG1 upregulates FGFR1 expression by sponging miR-497, which promotes the progression of PC. +other 35140604 hsa-mir-34a Osteoarthritis Furthermore, changes of miR-146a-5p and miR-34a-5p in the cellular models were recovered by DHJSD administration, which synergistically contributed to OA therapy. +other 35140604 hsa-mir-146a Osteoarthritis Furthermore, changes of miR-146a-5p and miR-34a-5p in the cellular models were recovered by DHJSD administration, which synergistically contributed to OA therapy. +other 35140551 hsa-mir-615 Sarcoma, Kaposi 5p, miR-1908, miR-3180, miR-4433b-3p) which have not been described in the literature in the context of Kaposi's sarcoma were addressed in the study for the first time and 9 novel miRNAs, not found previously in the database, have been detected in Kaposi's sarcoma using the miRNA-sequencing technique. +other 35140551 hsa-mir-92b Sarcoma, Kaposi 5p, miR-1908, miR-3180, miR-4433b-3p) which have not been described in the literature in the context of Kaposi's sarcoma were addressed in the study for the first time and 9 novel miRNAs, not found previously in the database, have been detected in Kaposi's sarcoma using the miRNA-sequencing technique. +other 35140551 hsa-mir-3180 Sarcoma, Kaposi 5p, miR-1908, miR-3180, miR-4433b-3p) which have not been described in the literature in the context of Kaposi's sarcoma were addressed in the study for the first time and 9 novel miRNAs, not found previously in the database, have been detected in Kaposi's sarcoma using the miRNA-sequencing technique. +other 35140551 hsa-mir-4433b Sarcoma, Kaposi 5p, miR-1908, miR-3180, miR-4433b-3p) which have not been described in the literature in the context of Kaposi's sarcoma were addressed in the study for the first time and 9 novel miRNAs, not found previously in the database, have been detected in Kaposi's sarcoma using the miRNA-sequencing technique. +other 35140551 hsa-mir-490 Sarcoma, Kaposi 5p, miR-1908, miR-3180, miR-4433b-3p) which have not been described in the literature in the context of Kaposi's sarcoma were addressed in the study for the first time and 9 novel miRNAs, not found previously in the database, have been detected in Kaposi's sarcoma using the miRNA-sequencing technique. +other 35140551 hsa-mir-1908 Sarcoma, Kaposi 5p, miR-1908, miR-3180, miR-4433b-3p) which have not been described in the literature in the context of Kaposi's sarcoma were addressed in the study for the first time and 9 novel miRNAs, not found previously in the database, have been detected in Kaposi's sarcoma using the miRNA-sequencing technique. +exosome 35140333 hsa-mir-940 Carcinoma, Hepatocellular Apart from the downregulation of HIF-1a/VEGF expression in HCC cells, PBLD also blocks VEGF receptor 2 (VEGFR2) on endothelial cells via HCC-derived exosomal miR-940. +other 35139769 hsa-mir-145 Cardiomegaly Collectively, our findings have indicated that the H19/miR3p/SMAD4 axis should be a negative regulator involved in CH progression. +circulation_biomarker_diagnosis_up 35139491 hsa-mir-601 Glioblastoma The effects of miR-601 dysregulation on GBM cell proliferation by mean transit time (brain tissue blood flow) (MTT) assays, colony formation, anchorage-independent growth assay, bromodeoxyuridine (BrdU) labeling and immunofluorescence assay. +transcription factor target 35138580 hsa-mir-103 Osteoarthritis In this study, the levels of VMA21, pre-miR-103, and mature miR-103 in synovial fluid samples from OA patients (n = 56) and controls (n = 56) were analyzed using RT-qPCR. +genetics_overexpression_promote 35138469 hsa-mir-586 Stomach Neoplasms Exosomal circ_0001190 overexpression inhibited the development of GC by miR-586/SOSTDC1 axis, which proposed a potential targeted therapy for GC cure. +other 35138425 hsa-mir-137 Neurotic Disorders Duration of methamphetamine use or abstinence, cigarette smoking status, depressive disorder, or antidepressant treatment did not interact with the methamphetamine abstinence-induced reduction of cEV miR-137. +other 35137927 hsa-mir-1262 Sepsis These findings highlighted the importance of the hsamiR1262/SLC2A1 signaling pathway in septic myocardial injury and provided novel insights into therapeutic strategies for septic myocardial depression. +exosome 35137672 hsa-mir-374a Fibrosis, Renal In conclusion, exosomal miR-374a-5p inhibited the progression of renal fibrosis by regulating MAPK6/MK5/YAP axis. +other 35137671 hsa-mir-17 Parkinson Disease Here, we addressed the role of lncRNA miR92a-1 cluster host gene (MIR17HG) in Parkinson's disease (PD). +lncRNA target 35137671 hsa-mir-153 Parkinson Disease Overall, MIR17HG, by targeting miR +lncRNA target 35137670 hsa-mir-139 Stomach Neoplasms 3p inhibited proliferative, migratory, and invasive abilities of GC cells, while caused cell-cycle arrest. +circRNA target 35137664 hsa-mir-15b Wounds and Injuries circCHFR expression was upregulated in patients with atherosclerosis and oxidized low-density lipoprotein (ox-LDL)-exposed HUVECs, whereas miR-15b-5p expression was downregulated. In conclusion, circCHFR promotes atherosclerosis progression via the miR-15b-5p/GADD45G axis and may be an important target for atherosclerosis treatment. +lncRNA target 35137654 hsa-mir-21 Neuroma, Acoustic BRCAT54 suppressed primary VS cell proliferation and inhibited the role of miR-21 in promoting cell proliferation. +lncRNA target 35137650 hsa-mir-10a Carcinoma, Non-Small-Cell Lung In NSCLC cells, LINRIS silencing showed no role in miR-10a precursor accumulation but downregulated mature miR10a level. Overall, LINRIS silencing may inhibit NSCLC cell proliferation by suppressing miR-10a maturation.Abbreviations: Non-small cell lung cancer (NSCLC); Reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR); LncRNA long intergenic noncoding RNA for IGF2BP2 stability (LINRIS). +lncRNA target 35137600 hsa-mir-139 Carcinoma, Hepatocellular 3p regulated cell behaviors in HCC through targeting UCK2. +transcription factor target 35137483 hsa-mir-520c Pre-Eclampsia RESULTS: Low expression of MT1, MT2, and miR-520c-3p and high expression of SETD7 and HtrA1 were observed in the placental tissues of PE patients and H/R-treated HTR8/Svneo cells. CONCLUSION: Melatonin may inhibit HtrA1 transcription through the miR-520c-3p/SETD7 axis to promote trophoblast invasion and migration and reduce trophoblast pyroptosis in PE. +exosome 35137328 hsa-mir-200a Esophageal Squamous Cell Carcinoma Our results suggest that exosome-shuttled miR-200a might be useful as a biomarker for prognosis in patients with ESCC. +lncRNA target 35137264 hsa-mir-23a Subarachnoid Hemorrhage Overall, suppression of miR-23a-3p improves cognitive function after SAH by targeting VCAN. +other 35137158 hsa-mir-26 Alcohol Withdrawal Delirium We experimentally tested 37 TDMDfinder predictions, of which 17 showed TDMD effects as measured by RT-qPCR and small RNA sequencing, linking the miR-17, miR-19, miR-30, miR-221, miR-26 and miR-23 families to novel endogenous TDMDs. +other 35137158 hsa-mir-221 Muscular Dystrophy, Duchenne We experimentally tested 37 TDMDfinder predictions, of which 17 showed TDMD effects as measured by RT-qPCR and small RNA sequencing, linking the miR-17, miR-19, miR-30, miR-221, miR-26 and miR-23 families to novel endogenous TDMDs. +other 35137158 hsa-mir-23 Muscular Dystrophy, Duchenne We experimentally tested 37 TDMDfinder predictions, of which 17 showed TDMD effects as measured by RT-qPCR and small RNA sequencing, linking the miR-17, miR-19, miR-30, miR-221, miR-26 and miR-23 families to novel endogenous TDMDs. +other 35137158 hsa-mir-17 Alcohol Withdrawal Delirium We experimentally tested 37 TDMDfinder predictions, of which 17 showed TDMD effects as measured by RT-qPCR and small RNA sequencing, linking the miR-17, miR-19, miR-30, miR-221, miR-26 and miR-23 families to novel endogenous TDMDs. +other 35137158 hsa-mir-19 Alcohol Withdrawal Delirium We experimentally tested 37 TDMDfinder predictions, of which 17 showed TDMD effects as measured by RT-qPCR and small RNA sequencing, linking the miR-17, miR-19, miR-30, miR-221, miR-26 and miR-23 families to novel endogenous TDMDs. +other 35137158 hsa-mir-17 Muscular Dystrophy, Duchenne We experimentally tested 37 TDMDfinder predictions, of which 17 showed TDMD effects as measured by RT-qPCR and small RNA sequencing, linking the miR-17, miR-19, miR-30, miR-221, miR-26 and miR-23 families to novel endogenous TDMDs. +other 35137158 hsa-mir-23 Alcohol Withdrawal Delirium We experimentally tested 37 TDMDfinder predictions, of which 17 showed TDMD effects as measured by RT-qPCR and small RNA sequencing, linking the miR-17, miR-19, miR-30, miR-221, miR-26 and miR-23 families to novel endogenous TDMDs. +other 35137158 hsa-mir-26 Muscular Dystrophy, Duchenne We experimentally tested 37 TDMDfinder predictions, of which 17 showed TDMD effects as measured by RT-qPCR and small RNA sequencing, linking the miR-17, miR-19, miR-30, miR-221, miR-26 and miR-23 families to novel endogenous TDMDs. +other 35137158 hsa-mir-19 Muscular Dystrophy, Duchenne We experimentally tested 37 TDMDfinder predictions, of which 17 showed TDMD effects as measured by RT-qPCR and small RNA sequencing, linking the miR-17, miR-19, miR-30, miR-221, miR-26 and miR-23 families to novel endogenous TDMDs. +other 35137158 hsa-mir-221 Alcohol Withdrawal Delirium We experimentally tested 37 TDMDfinder predictions, of which 17 showed TDMD effects as measured by RT-qPCR and small RNA sequencing, linking the miR-17, miR-19, miR-30, miR-221, miR-26 and miR-23 families to novel endogenous TDMDs. +lncRNA target 35136398 hsa-mir-21 Myocardial Reperfusion Injury 5p/PDCD4 signaling pathway that mediates the apoptosis of cardiomyocytes and successfully alleviates IRI in myocardial cells by co-culture with miR +genetics_GWAS 35136075 hsa-mir-125a Intracranial Aneurysm Therefore, an increased level of miR-125a can lead to the increased risk of IA re-bleeding. Since miR-125a level is higher in CC-genotyped patients, it can be concluded that the presence of T allele in the rs12976445 polymorphism is associated with a lower risk of IA re-bleeding, and miR-125a may be used as a novel diagnostic and therapeutic target for IA rupture. +exosome 35136055 hsa-mir-494 Lung Neoplasms 3p inhibitor blocked sEV-mediated effects by targeting tyrosine-protein phosphatase nonreceptor type 12 (PTPN12), a tumor suppressor. +lncRNA target 35136049 hsa-mir-578 Intervertebral Disc Degeneration These data suggested that circ_0134111 could promote the progression of IDD through enhancing aberrant NP cell growth, inflammation, and ECM degradation partly via regulating miR-578. +lncRNA target 35136034 hsa-mir-10b Glioblastoma We further identify a SOX2:miR-10b-5p:TET2 axis that represses TET2 expression, represses 5hmC, increases 5mC levels, and induces GBM cell stemness and tumor-propagating potential. In vivo delivery of a miR-10b-5p inhibitor that normalizes TET2 expression and 5hmC levels inhibits tumor growth and prolongs survival of animals bearing pre-established orthotopic GBM xenografts. +lncRNA target 35136029 hsa-mir-150 Myelodysplastic Syndromes 5p/MYB positive feedback loop promoted the proliferation of MDS cells and is expected to be a potential biomarker and therapeutic target in MDS. +exosome 35136028 hsa-mir-7 Carcinoma, Non-Small-Cell Lung 5p loaded exosomes from NSCLC cells in Rab27A and Rab27B dependent manners. +circulation_biomarker_diagnosis_ns 35135571 hsa-mir-21 Ataxia Neuropathy Spectrum CONCLUSIONS: Furthermore, the proposed assay was applied for detecting microRNA-21 in dilute human serum samples with satisfactory recovery and also in MCF-7 cell lines in the range 3000 to 45,000 (cell mL(-1)) with a detection limit (3 cells in 10 muL), demonstrating the potential of the assay for clinic diagnosis of microRNA-associated disease. +transcription factor target 35135443 hsa-mir-99a Spinal Cord Injuries To sum up, miR-99a suppresses NOX4 expression to relieve the LPS-induced inflammation, apoptosis and the progression of oxidative stress in SCI. +transcription factor target 35135443 hsa-mir-99a Inflammation To sum up, miR-99a suppresses NOX4 expression to relieve the LPS-induced inflammation, apoptosis and the progression of oxidative stress in SCI. +genetics_knock down_promote 35135416 hsa-mir-514a Thyroid Neoplasms Besides, circ-ZNF609 sponged miR-514a-5p and miR-514a-5p knockdown reversed the suppressed impacts of circ-ZNF609 knockdown on TC cell malignant biological behaviors. +other 35134991 hsa-mir-1305 Nerve Degeneration Of the 39 miRNAs, 5 miRNAs, 3 downregulated (miR-20a, miR-30b, and miR-30d) and 3 upregulated (miR-1243 and miR-1305), correlated well with morphological changes induced by multiple neurotoxicants and were notable based on their relationship to various neurodegenerative conditions and/or key pathways, such as TGF-beta signaling. +other 35134991 hsa-mir-20a Nerve Degeneration Of the 39 miRNAs, 5 miRNAs, 3 downregulated (miR-20a, miR-30b, and miR-30d) and 3 upregulated (miR-1243 and miR-1305), correlated well with morphological changes induced by multiple neurotoxicants and were notable based on their relationship to various neurodegenerative conditions and/or key pathways, such as TGF-beta signaling. +lncRNA target 35134495 hsa-mir-198 Carcinoma, Non-Small-Cell Lung Circ_0004015 conferred DDP resistance and promoted NSCLC progression by miR-198/KLF8 pathway, proving a potential target for studying DDP-mediated treatment of NSCLC. +lncRNA target 35133561 hsa-mir-122 Cardiomyopathies Collectively, these data indicated that miRNA5p is an essential regulator of autophagy and apoptosis in rat CFs via the apelin/AMPK/mTOR signaling pathway, which may be potentially used as a therapeutic target in myocardial fibrosis and related diseases. +transcription factor target 35133054 hsa-mir-16 Lymphoma, T-Cell, Cutaneous We have previously demonstrated that histone deacetylase inhibitors restore tumor-suppressive miRNAs, such as miR-16, miR-29, miR-150, and miR-26, in advanced cutaneous T-cell lymphoma (CTCL). +transcription factor target 35133054 hsa-mir-150 Lymphoma, T-Cell, Cutaneous We have previously demonstrated that histone deacetylase inhibitors restore tumor-suppressive miRNAs, such as miR-16, miR-29, miR-150, and miR-26, in advanced cutaneous T-cell lymphoma (CTCL). +genetics_knock down_promote 35133054 hsa-mir-26 Lymphoma, T-Cell, Cutaneous In vitro analysis of IL22 and IL22RA knockdown and miR-26 transduction demonstrated inhibited CTCL cell migration. +transcription factor target 35133054 hsa-mir-29 Lymphoma, T-Cell, Cutaneous We have previously demonstrated that histone deacetylase inhibitors restore tumor-suppressive miRNAs, such as miR-16, miR-29, miR-150, and miR-26, in advanced cutaneous T-cell lymphoma (CTCL). +genetics_knock down_promote 35133000 hsa-mir-377 Adenocarcinoma of Lung 3p was able to promote gefitinib resistance in spite of hsa_circ_0000567 knockdown. +other 35132928 hsa-mir-1182 Carcinoma, Non-Small-Cell Lung Together, our findings reveal a novel mechanism by which the circCAMSAP1/miR-1182/BIRC5 axis promotes NSCLC progression. +lncRNA target 35132819 hsa-mir-579 Carcinoma, Hepatocellular 3p was identified as a novel tumor suppressor regulating phosphoinositide 3-kinase-AKT signaling at the early stages of HCC development. +transcription factor target 35132534 hsa-mir-485 Sleep Apnea, Obstructive 5p alleviates OSAS with hypertension by inhibiting the PI3K/Akt pathway via downregulating HIF3A expression through the PI3K/AKT pathway. +genetics_overexpression_promote 35132352 hsa-mir-21 Peripheral Nerve Injuries Furthermore, the effects of Schwann cells- (SC-) derived exosomes on the overexpression of miR-21 for the treatment of PNI were investigated. +other 35132320 hsa-mir-580 Ovarian Neoplasms Long Noncoding RNA RMRP Contributes to Paclitaxel Sensitivity of Ovarian Cancer by Regulating miR-580-3p/MICU1 Signaling. +lncRNA target 35131594 hsa-mir-22 Liver Diseases The objective of this study is to investigate the internal mechanism by which microRNA-22 (miR-22) targets family with sequence similarity 49 member B (FAM49B), thus aggravating hepatic I/R injury. Here, we found that miR-22 was upregulated while FAM49B was reduced in hepatic I/R injury. +transcription factor target 35131475 hsa-mir-146a Condylomata Acuminata Subsequently, we verified four up-regulated hub genes IFIT1, IFI27, OASL, SAMD9L and down-regulated mir-146a-5p in CA tissues by RT-qPCR. Our study revealed that mir-146a-5p contribute to CA progression through PI3K/AKT and p38/MAPK signaling pathway. +other 35131296 hsa-mir-34a Neurotic Disorders AAV-miR-34a in PL produced antidepression-behavioral effects and rescued stress-induced depressive-like behaviors. Intra-PL application of miR-34a rapidly produced antidepression-like effects and reversed stress-evoked depressive-like behaviors. +lncRNA target 35130798 hsa-mir-197 Carcinoma, Endometrioid Collectively, hsa_circ_0039569 may promote the development of endometrial carcinoma by serving as an endogenous sponge of miR-197, increasing HMGA1 expression and identifying a novel target for endometrial carcinoma treatment. +other 35130632 hsa-mir-1205 Triple Negative Breast Neoplasms Utilizing qRT-PCR analysis, we discovered that miR-1205 is gradually downregulated in human triple negative breast carcinoma MDA-MB-231 and docetaxel-resistant MDA-MB-231 (MDA-MB-231/DOC) cells compared with Hs 578Bst normal human breast fibroblasts. Our findings demonstrate the role of the miR-1205/DNAJB1 axis in the docetaxel resistance of TNBC, which may offer a promising therapeutic approach to resolve docetaxel resistance in TNBC. +other 35130629 hsa-mir-493 Osteosarcoma 5p. +exosome 35130628 hsa-mir-27b Tendon Injuries Taken together, our findings highlight a critical role of hucMSC exosomes in reducing tendon injury via miR-27b-3p-mediated suppression of ARHGAP5, resulting in RhoA activation, and leading to increased cell proliferation and invasion of primary injured tenocytes. +lncRNA target 35130616 hsa-mir-665 Carcinoma, Hepatocellular A rescue experiment demonstrated that silencing of eliminats the inhibitory effect of the miR-665 inhibitor on sorafenib resistance in HCC cells. +circulation_biomarker_diagnosis_ns 35130573 hsa-mir-128 Duane Retraction Syndrome 3p, and there was a negative correlation in the serum of DR patients. +genetics_overexpression_promote 35130572 hsa-mir-551b Thyroid Cancer, Papillary The overexpression of miR-551b exerted promoted effect on the development-related cellular processes of PTC, which was reversed by the overexpression of ERBB4. +other 35129856 hsa-mir-21 Carcinoma, Renal Cell 3p predicted reduced survival (p < 0.05). +other 35129856 hsa-mir-221 Carcinoma, Renal Cell 3p predicted reduced survival (p < 0.05). +other 35129856 hsa-mir-222 Carcinoma, Renal Cell 3p predicted reduced survival (p < 0.05). +transcription factor target 35129808 hsa-mir-182 Carcinoma, Renal Cell 5p inhibited UBE2T protein expression by targeting UBE2T mRNA and then inhibited the proliferation, migration and invasion of ccRCC cell. +other 35129780 hsa-mir-146a Breast Neoplasms MALAT-1/p53/miR-155/miR-146a ceRNA circuit tuned by methoxylated quercitin Triple-Negative Breast Cancer (TNBC) is one of the most aggressive and hot BC subtypes. +other 35129780 hsa-mir-155 Breast Neoplasms MALAT-1/p53/miR-155/miR-146a ceRNA circuit tuned by methoxylated quercitin Triple-Negative Breast Cancer (TNBC) is one of the most aggressive and hot BC subtypes. +genetics_knock down_promote 35129574 hsa-mir-33a Ovarian Neoplasms Notably, silencing of LINC00974 suppressed cell proliferation, invasion and EMT of OC cells, whereas miR-33a knockdown partially reversed the phenotypes of LINC00974 on OC cells. +other 35129424 hsa-mir-29b-2 Diabetic Nephropathies Finally, the hsa_circRNA_012448-hsa-miR-29b5p-GSK3beta pathway, involved in the oxidative stress response, was identified as an important pathway mediating the action of dapagliflozin against DKD. +circulation_biomarker_diagnosis_up 35129398 hsa-mir-485 Norrie disease 5p and upregulation of YAP1 were also observed in the serum of DN patients. +transcription factor target 35129398 hsa-mir-485 Inflammation CONCLUSION: Quercetin inhibits the proliferation, inflammation, and oxidative stress of HMCs induced by HG through miR +genetics_overexpression_promote 35129056 hsa-mir-149 Esophageal Squamous Cell Carcinoma RNF2 overexpression blocked the inhibitory effect of miR-149 on ESCC cell growth. +circulation_biomarker_diagnosis_up 35129049 hsa-mir-154 Mycoses We found that, compared with normal transplanted patients, the levels of miR-215 and miR-let-7 c were up-regulated in the plasma of patients with fungal infection (P < 0.01), while levels of miR-154, miR-193a, NR_027669.1, and NR_036506.1 were down-regulated in their peripheral blood mononuclear cells (P < 0.01). +circulation_biomarker_diagnosis_up 35129049 hsa-let-7c Mycoses We found that, compared with normal transplanted patients, the levels of miR-215 and miR-let-7 c were up-regulated in the plasma of patients with fungal infection (P < 0.01), while levels of miR-154, miR-193a, NR_027669.1, and NR_036506.1 were down-regulated in their peripheral blood mononuclear cells (P < 0.01). +circulation_biomarker_diagnosis_up 35129049 hsa-mir-215 Mycoses We found that, compared with normal transplanted patients, the levels of miR-215 and miR-let-7 c were up-regulated in the plasma of patients with fungal infection (P < 0.01), while levels of miR-154, miR-193a, NR_027669.1, and NR_036506.1 were down-regulated in their peripheral blood mononuclear cells (P < 0.01). +circulation_biomarker_diagnosis_up 35129049 hsa-mir-193a Mycoses We found that, compared with normal transplanted patients, the levels of miR-215 and miR-let-7 c were up-regulated in the plasma of patients with fungal infection (P < 0.01), while levels of miR-154, miR-193a, NR_027669.1, and NR_036506.1 were down-regulated in their peripheral blood mononuclear cells (P < 0.01). +circulation_biomarker_diagnosis_up 35128324 hsa-mir-155 Arthritis, Rheumatoid CONCLUSIONS: Upregulated levels of miR-146a, miR-103a, and miR-155 in the whole blood samples of RA patients could confer a potential marker of activity-severity of the disease in RA patients with established disease. +circulation_biomarker_diagnosis_up 35128324 hsa-mir-146a Arthritis, Rheumatoid CONCLUSIONS: Upregulated levels of miR-146a, miR-103a, and miR-155 in the whole blood samples of RA patients could confer a potential marker of activity-severity of the disease in RA patients with established disease. +circulation_biomarker_diagnosis_up 35128324 hsa-mir-103a Arthritis, Rheumatoid CONCLUSIONS: Upregulated levels of miR-146a, miR-103a, and miR-155 in the whole blood samples of RA patients could confer a potential marker of activity-severity of the disease in RA patients with established disease. +genetics_overexpression_suppress 35128082 hsa-mir-29b Osteoarthritis microRNA-29b-3p (miR-29b-3p) is downregulated by TGF-beta1 and overexpressed in OA cartilage. Furthermore, implying that miR-29b-3p expression may be involved in reduced chondrocyte proliferation in OA. +lncRNA target 35127996 hsa-mir-194 Intervertebral Disc Degeneration 5p derived from MSCs-EVs protects TNF-alpha-intervened NP cells through restricting TRAF6, replenishing a potential target for IDD treatment. +target gene 35127818 hsa-mir-142 Urinary Bladder Neoplasms MIR100HG Regulates CALD1 Gene Expression by Targeting miR-142-5p to Affect the Progression of Bladder Cancer Cells in vitro. +other 35127724 hsa-mir-124 Urinary Bladder Neoplasms 5p) involved in GEM-resistant BCa. +other 35127724 hsa-mir-26b Urinary Bladder Neoplasms 5p) involved in GEM-resistant BCa. +other 35127724 hsa-mir-192 Urinary Bladder Neoplasms 5p) involved in GEM-resistant BCa. +exosome 35127706 hsa-mir-151 Spinal Cord Injuries 3p is the key molecule in microglia-derived exosomes that mediates the neuroprotective effects of SCI treatments. +target gene 35127703 hsa-mir-188 Myocardial Infarction The circRNA_0002113/miR-188-3p/RUNX1 axis mediated alleviation of apoptosis serves as a novel strategy to treat myocardial I/R injury. +tissue_expression_up 35127575 hsa-mir-549a Multiple Sclerosis Due to the presence of a possible relationship between expressed miRNAs and heterogeneous appearances of the pathological processes in MS, the present study attempts to evaluate the expression of miR-129 and miR-549a in patients with MS in comparison with healthy control (HC) group. After RNA extraction and complementary DNA synthesis, the expression of miR-129 and miR-549a was evaluated in patients with MS in comparison with the HC group using a quantitative real-time polymerase chain reaction assay. RESULTS: The results showed that the expression of miR-129 and miR-549a was not significant in patients with MS in comparison with the HC group. +tissue_expression_up 35127575 hsa-mir-129 Multiple Sclerosis Due to the presence of a possible relationship between expressed miRNAs and heterogeneous appearances of the pathological processes in MS, the present study attempts to evaluate the expression of miR-129 and miR-549a in patients with MS in comparison with healthy control (HC) group. After RNA extraction and complementary DNA synthesis, the expression of miR-129 and miR-549a was evaluated in patients with MS in comparison with the HC group using a quantitative real-time polymerase chain reaction assay. RESULTS: The results showed that the expression of miR-129 and miR-549a was not significant in patients with MS in comparison with the HC group. +other 35127565 hsa-mir-34 Lymphomatoid Granulomatosis There was no significant difference in the expression of PMK-1 for LGG exposure in miR-34 mutants, suggesting that miR-34 may regulate PMK-1. +genetics_overexpression_promote 35127344 hsa-mir-375 Carcinoma, Hepatocellular miR-375 was downregulated in HCC, and overexpression of miR-375 suppressed HCC cell growth. +genetics_overexpression_promote 35127343 hsa-mir-138 Glioma RESULTS: Functional studies indicated that overexpression of miR +genetics_knock down_suppress 35127342 hsa-mir-944 Uterine Cervical Neoplasms circ_ZFR knockdown significantly reduced IL-10 expression via sponging miR-944, increasing PTX sensitivity in PTX-resistant CC cells. CONCLUSION: circ_ZFR knockdown has a considerable role in overwhelming CC-associated PTX resistance by modifying the axis of miR-944/IL-10 axis, suggesting that developing a circRNA target-based treatment could be considered prevent CC progression. +genetics_knock down_promote 35127282 hsa-mir-148a Urinary Bladder Neoplasms miR-148a-3p overexpression inhibited bladder cancer cell proliferation and migration, whereas miR-148a-3p knockdown promoted bladder cancer cell proliferation and migration. +other 35127170 hsa-mir-4521 Carcinoma, Hepatocellular These discoveries suggest that miR-4521/FAM129A might play a vital role in hepatic cancer progression and could be a candidate for its therapy. +lncRNA target 35126948 hsa-mir-206 Endometriosis Hence, miR-206 was suggested to be a possible target for EM treatment. +transcription factor target 35126933 hsa-mir-98 Intervertebral Disc Degeneration We concluded that miR-98 inhibited apoptosis of NP cells by inactivating the TRAIL pathway via targeting TRAIL in IVDD NP cells. +genetics_knock down_promote 35126911 hsa-mir-25 Diabetic Nephropathies More importantly, downregulation of miR-325 and upregulation of CCNG1 can attenuate the protective effect of lncRNA MSC-AS1 knockdown on DN. +other 35126901 hsa-mir-149 Thyroid Neoplasms Additionally, miR5p weakened the effect of CCL18 in the progression of TC. +transcription factor target 35126820 hsa-mir-154 Pulmonary Fibrosis CONCLUSION: miR5p regulates the TGFbeta1/Smads pathway through Smurf1 ubiquitination and promotes the fibrosis process of diabetic kidney disease. +transcription factor target 35126820 hsa-mir-154 Diabetic Nephropathies CONCLUSION: miR5p regulates the TGFbeta1/Smads pathway through Smurf1 ubiquitination and promotes the fibrosis process of diabetic kidney disease. +circRNA target 35126807 hsa-mir-138 Myocardial Reperfusion Injury Overall, our findings suggest that circ_SMG6 may deteriorate myocardial I/R injury by promoting neutrophil recruitment via the miR +other 35126805 hsa-mir-19b Heart Diseases The QK/miR-19b/Socs6 axis plays a vital role in regulation of mitochondrial fission and cardiomyocyte apoptosis and could form the basis of future research in the development of therapies for the management of cardiac diseases. +transcription factor target 35126805 hsa-mir-19b familial febrile seizures 1 CONCLUSIONS: Our results indicate that the inhibition of mitochondrial fission through downregulating Socs6 via the QK/miR-19b/Socs6 pathway attenuated the damage sustained by I/R. +circulation_biomarker_diagnosis_ns 35126729 hsa-mir-26a Colorectal Neoplasms Overall, the present study revealed serum miR-26a-5p as a potential early detection marker for CRC. +target gene 35126724 hsa-mir-224 Carcinoma, Hepatocellular E2F1-induced microRNA-224-5p expression is associated with hepatocellular carcinoma cell migration, invasion and epithelial-mesenchymal transition via MREG. +genetics_knock down_suppress 35126706 hsa-mir-214 Maxillary Fractures Altogether, it was revealed that TUG1 expression was decreased in patients with maxillary fractures and TUG1 knockdown repressed the biological process of osteoblasts by sponging miR-214. +lncRNA target 35126697 hsa-mir-98 Osteoporosis Kcnq1ot1, miR5p and Tbx5 may therefore serve as promising targets for the treatment of osteoporosis. +lncRNA target 35126637 hsa-let-7b Rotator Cuff Injuries CONCLUSIONS: A hyperglycemic microenvironment inhibits TDSC proliferation in vitro via the let-7b-5p/CFTR pathway, and this is a potential mechanism in diabetes-induced poor tendon-to-bone healing. +genetics_overexpression_promote 35126623 hsa-mir-1 Carcinoma, Non-Small-Cell Lung After interference with or overexpressing miR +lncRNA target 35126622 hsa-mir-204 Breast Neoplasms 5p inhibitor on cell functions of BC. +lncRNA target 35126619 hsa-mir-143 Urinary Bladder Neoplasms 3p repressed bladder cancer cell functions and EMT through downregulating TBX3 expression. +other 35126595 hsa-mir-25 Adenocarcinoma of Lung CONCLUSIONS: The interaction of miR-25 and PTEN in young LUAD may define a subgroup of patients, highlighting the concept of molecular testing in different age subtypes. +other 35126571 hsa-mir-10b Melanoma The current study is aimed to assess the values of microRNA-10b (miRNA-10b) in the discrimination of metastatic melanomas. CONCLUSION: Based on this study, metastatic melanoma was associated with elevated levels of miRNA-10b. +circulation_biomarker_prognosis_ns 35126518 hsa-mir-1246 Lung Neoplasms Finally, exosomal miR-1246 serum may be a useful prognosis biomarker for non-small-cell lung cancer. +other 35126169 hsa-mir-34a Fibrosis "These findings suggest that age-related fibrosis and muscle atrophy mediated by ROS may result at least in part from an increase in miR-34a bioavailability resulting from a decline in miR-34a ""sponging"" due to ceRNA MALAT1 depletion." +other 35126169 hsa-mir-34a Muscular Atrophy "These findings suggest that age-related fibrosis and muscle atrophy mediated by ROS may result at least in part from an increase in miR-34a bioavailability resulting from a decline in miR-34a ""sponging"" due to ceRNA MALAT1 depletion." +lncRNA target 35126113 hsa-let-7 Non-alcoholic Fatty Liver Disease The present data suggest that the protective effects of fenofibrate against insulin resistance and its suppressive activity against excessive hepatic lipid accumulation may be related to the alteration of the let-7/SERCA2b axis and alleviation of ER stress. +exosome 35125496 hsa-mir-133b Diabetic Retinopathy This study has elucidated that exosomal miR-133b-3p from BMSCs suppresses angiogenesis and oxidative stress in DR via FBN1 repression. +genetics_GWAS 35124585 hsa-mir-135a Polycystic Ovary Syndrome CONCLUSION: The results revealed the two SNPs as rs2289046 and rs1865434 in the IRS-2 binding region of miRNA-135a have correlations with the clinical features of PCOS in Chinese population. +genetics_overexpression_suppress 35124548 hsa-mir-4269 Colorectal Neoplasms The nuclear overexpressed TEAD4 and downregulated miR-4269 and miR +genetics_overexpression_suppress 35124548 hsa-mir-1343 Colorectal Neoplasms The nuclear overexpressed TEAD4 and downregulated miR-4269 and miR +lncRNA target 35124415 hsa-mir-21 Lupus Erythematosus, Systemic In conclusion, inhibiting miR-21 in vivo improves intracellular iron homeostasis and inhibits Tfh cell overexpansion, contributing to reduced autoimmune responses and the remission of disease symptoms in murine lupus. +lncRNA target 35124344 hsa-mir-624 Ovarian Neoplasms High expression of miR5p was recorded in ovarian drug resistant cancer cells and it also boosted the cell viabilities. +genetics_knock down_promote 35123924 hsa-mir-338 Parkinson Disease CONCLUSION: To sum up, our data revealed that knockdown LINC00943 might alleviate PD progression through regulating the miR3p/SP1 axis. +other 35123634 hsa-mir-181a Thrombocytopenia CONCLUSION: The expression of miR-181a-5p is significantly decreased in ITP patients, which is closely related to the imbalance of Treg/Th17 cells. +epigenetics 35123558 hsa-mir-935 Urinary Bladder Neoplasms RESULTS: All nine urinary methylation markers (FAM19A4, GHSR, MAL, miR-129, miR-935, PHACTR3, PRDM14, SST and ZIC1) showed significantly higher methylation levels in bladder cancer patients than in controls (p < 0.001). +epigenetics 35123558 hsa-mir-129 Urinary Bladder Neoplasms RESULTS: All nine urinary methylation markers (FAM19A4, GHSR, MAL, miR-129, miR-935, PHACTR3, PRDM14, SST and ZIC1) showed significantly higher methylation levels in bladder cancer patients than in controls (p < 0.001). +lncRNA target 35123415 hsa-mir-152 Prostatic Neoplasms It was noted that SNHG3 as a molecular sponge of miR3p stimulated proliferation, migration, and invasion, restrained methionine dependence and apoptosis, and affected the cell cycle of PCa cells via targeting SLC7A11. +exosome 35123060 hsa-mir-382 Fluoride Poisoning Conclusions PVAT-EXOs reduce macrophage foam cell formation through miR +transcription factor target 35122989 hsa-mir-9 Pulmonary Fibrosis Up-regulated C-MYC promoted proliferation and differentiation of pulmonary fibroblasts by inhibiting TBPL1 via activation of miR +circRNA target 35122957 hsa-mir-383 Osteoarthritis CONCLUSION: Circ_Rapgef1 suppressed AD-mediated protective effects in OA partly by regulating miR3p/NLRP3 signaling. +circulation_biomarker_diagnosis_ns 35122770 hsa-mir-483 COVID-19 In conclusion, high levels of circulating miR-320b and miR +circulation_biomarker_diagnosis_ns 35122770 hsa-mir-20b COVID-19 In conclusion, high levels of circulating miR-320b and miR +circulation_biomarker_prognosis_ns 35122598 hsa-mir-126 Sepsis CONCLUSION: This study confirmed that miR-126 can regulate the differentiation of Th17/Treg, change the infiltration of inflammatory factors in peripheral blood, lung, liver and kidney of septic rats, alleviate MODS, and improve the organ function and prognosis of septic rats. +other 35122570 hsa-mir-16 Rhinitis, Allergic induced dysfunction of NECs by lncRNA HCP5 depended on miR-16/ATXN2L in the inflammatory response of AR. +lncRNA target 35121826 hsa-mir-135 Breast Neoplasms Collectively, our findings highlighted the role of the miR-135/ZNF217/METTL3/NANOG axis in the progression of BC, emphasizing potential therapeutic targets ZNF217 silencing and miR-135 upregulation in preventing or treating BC. +lncRNA target 35121558 hsa-mir-183 X-linked juvenile retinoschisis 1 In conclusion, we found that SNHG1 plays a critical role in the progression of RSA via miR5p/ZEB2 and Wnt/beta-catenin signaling. +circulation_biomarker_diagnosis_up 35121374 hsa-mir-448 Lupus Erythematosus, Systemic In our study, we found high expression of miR-448 in peripheral blood mononuclear cells (PBMCs) of SLE patients, and miR-448 level was positively associated with disease severity. +other 35121166 hsa-mir-760 Pre-Eclampsia 5p/HMGCS1 and hsa_circ_0001513/hsa_circ_0001329/hsa-miR-760/MAP1 axes may participate in the pathological process of PE. +other 35121166 hsa-mir-532 Pre-Eclampsia 5p/HMGCS1 and hsa_circ_0001513/hsa_circ_0001329/hsa-miR-760/MAP1 axes may participate in the pathological process of PE. +other 35121166 hsa-mir-188 Pre-Eclampsia 5p/HMGCS1 and hsa_circ_0001513/hsa_circ_0001329/hsa-miR-760/MAP1 axes may participate in the pathological process of PE. +genetics_overexpression_promote 35121085 hsa-mir-143 Urinary Bladder Neoplasms The influence of miR-143 overexpression on BC cells migration, proliferation, and apoptosis was detected using wound-healing assay, MTT assay, and DAPI and Annexin V/PI staining, respectively. +other 35120971 hsa-mir-452 Allergic Airway Inflammation 5p provided an alternative approach for the therapeutic intervention of epithelial remodeling in allergic airway inflammation. +transcription factor target 35120580 hsa-mir-26a Colonic Neoplasms RESULTS: Cordycepin inhibited colon cancer cell proliferation by down-regulating MYC mRNA/protein expression and up-regulating miR-26a in both HCT116 and Caco-2 cells. CONCLUSION: Cordycepin is able to suppress colon cancer cell proliferation, likely mediated by the MYC/miR-26a pathway, supporting its potential for the treatment of colon cancer. +lncRNA target 35120571 hsa-mir-19a Lupus Erythematosus, Systemic CONCLUSIONS: The circGARS sponges miR-19a to regulate YTHDF2 expression to promote SLE progression through the A20/NF-kappaB axis and may act as an independent biomarker to help the treatment of SLE patients. +other 35120526 hsa-mir-140 Fibroadenoma CONCLUSION: miR3p could become potential differential biomarker for BPT and FA. +other 35120526 hsa-mir-140 Phyllodes Tumor CONCLUSION: miR3p could become potential differential biomarker for BPT and FA. +lncRNA target 35119849 hsa-mir-21 Central Nervous System Diseases In this contribution, we demonstrate a palindrome-based hybridization chain reaction (PHCR) upon the stimuli of a short oligonucleotide trigger to perform the autonomous assembly of cross-linked network structures (CNSs) for the amplification detection of miRNA-21 and sensitive fluorescence imaging of cancerous cells. Utilizing the CHA-PHCR assay system, a small amount of miRNA-21 can activate many triggers via CHA and in turn induce the PHCR-based CNS assembly from more DNA building blocks, bringing Cy3 and Cy5 into close proximity to each other and generating ultrasensitive fluorescence resonance energy transfer signals. +lncRNA target 35119587 hsa-mir-9 Adenocarcinoma of Lung 5p fostered malignant behaviors of LUAD cells by targeting STARD13. +circulation_biomarker_diagnosis_down 35119164 hsa-mir-1304 Periodontitis CONCLUSIONS: Plasma-derived exosomal miRs (miR +circulation_biomarker_diagnosis_down 35119164 hsa-mir-200c Periodontitis CONCLUSIONS: Plasma-derived exosomal miRs (miR +lncRNA target 35119030 hsa-mir-1 Diabetic Nephropathies 3p was regulated by STAT1 and GJA1.To our knowledge, this study revealed for the first time the characteristic multiple components, multiple targets, and multiple pathways of AM thatseem to be the underlying mechanisms of action of AM in the treatment of DN with respect to miRNAs.Private information from individuals will not be published. +lncRNA target 35119030 hsa-mir-23 Diabetic Nephropathies 3p was regulated by STAT1 and GJA1.To our knowledge, this study revealed for the first time the characteristic multiple components, multiple targets, and multiple pathways of AM thatseem to be the underlying mechanisms of action of AM in the treatment of DN with respect to miRNAs.Private information from individuals will not be published. +lncRNA target 35119030 hsa-mir-206 Diabetic Nephropathies 3p was regulated by STAT1 and GJA1.To our knowledge, this study revealed for the first time the characteristic multiple components, multiple targets, and multiple pathways of AM thatseem to be the underlying mechanisms of action of AM in the treatment of DN with respect to miRNAs.Private information from individuals will not be published. +other 35118954 hsa-mir-199 Epstein-Barr Virus Infections We hypothesize that an EBV infection is responsible for the upregulation of the miRNA 199-3p, which binds to the 3'UTR of endothelin-1 (ET-1). +lncRNA target 35118606 hsa-mir-181 Necrosis Our study provided evidence that Cd may act through miR5p/TNF-alpha to induce necroptosis in swine lung. +transcription factor target 35118493 hsa-mir-29b Liver Cirrhosis The present study attempts to reveal the effect and mechanism of XSSJS via regulating miR-29b-3p/VEGFA axis against pathological angiogenesis in HF. In conclusion, XSSJS could modulate miR-29b-3p/VEGFA axis to inhibit the pathological angiogenesis of HF. +other 35118144 hsa-mir-29 Cardiomyopathies In vitro analysis of miR-29a effects on fibroblast and cardiac muscle cells pointed toward a protective role of miR-29a on aging-related fibrosis, by reducing cell migration and proliferation. In conclusion, our study indicates an adaptive increase of miR-29 in the natural aging process and suggests its role as a transcriptional repressor of SERPINH1, with a potential therapeutic value against adverse matrix remodeling and aging-associated tissue fibrosis. +other 35118144 hsa-mir-29a Cardiomyopathies In vitro analysis of miR-29a effects on fibroblast and cardiac muscle cells pointed toward a protective role of miR-29a on aging-related fibrosis, by reducing cell migration and proliferation. In conclusion, our study indicates an adaptive increase of miR-29 in the natural aging process and suggests its role as a transcriptional repressor of SERPINH1, with a potential therapeutic value against adverse matrix remodeling and aging-associated tissue fibrosis. +other 35118144 hsa-mir-18a Cardiomyopathies Among the miRNAs with documented roles in aging-related cardiac diseases, miR-18a, -21a, -22, and -29a were mainly associated with hypertrophy and/or fibrosis; however, their relationship to aging was not fully addressed before. +exosome 35118066 hsa-mir-486 Pituitary Neoplasms In conclusion, exosomal hsa-miR +lncRNA target 35117926 hsa-mir-153 Melanoma 3p exhibited suppressive effects via directly binding and downregulating ATG5 expression, which subsequently increased sensitivity to dacarbazine and inhibited proliferation, and enhanced apoptosis and autophagy in melanoma cells. +circulation_biomarker_diagnosis_ns 35117918 hsa-mir-17 Adenocarcinoma of Lung CONCLUSIONS: In conclusion, circulating miR-17 may be a quality diagnostic biomarker for LUAD screening, but confirmation by a large, rigorous clinical validation in a longitudinal setting is warranted. +lncRNA target 35117903 hsa-mir-101 Carcinoma, Hepatocellular Finally, treatment of BEL-7402 cells, an HCC cell line, with miR101-loaded MSCs led to significant proliferation inhibition and apoptosis of BEL-7402 cells. +exosome 35117898 hsa-mir-150 Osteosarcoma Mesenchymal stem cell-derived exosomes carrying microRNA-150 suppresses the proliferation and migration of osteosarcoma cells via targeting IGF2BP1. +target gene 35117890 hsa-mir-215 Colorectal Neoplasms low microRNA-215 expression as associated with a poor prognosis of patients with colorectal cancer through the IKβ-α signaling pathway. +target gene 35117886 hsa-mir-195 Thyroid Neoplasms hsa-miR-195-5p inhibits cell proliferation of human thyroid carcinoma cells via modulation of p21/cyclin D1 axis. +lncRNA target 35117854 hsa-mir-448 Carcinoma, Ovarian Epithelial CONCLUSIONS: Our study suggests that miR-448 has an inhibitory role in OC. +target gene 35117853 hsa-mir-214 Osteosarcoma Formononetin inhibits osteosarcoma cell proliferation and promotes apoptosis by regulating the miR-214-3p/phosphatase and tensin homolog pathway. +target gene 35117808 hsa-mir-132 Ovarian Neoplasms microRNA-132 inhibits the proliferation, migration, and invasion of ovarian cancer cells by regulating CT10 oncogenic gene homolog II-related signaling pathways. +genetics_knock down_promote 35117781 hsa-mir-494 Osteosarcoma Gain of miR-494 function suppressed OS tumor growth and promoted apoptosis of OS cells, while loss of miR-494 inhibited apoptosis and promoted invasion of osteoblastic cells. +target gene 35117763 hsa-mir-7 Carcinoma, Hepatocellular MicroRNA-7 inhibits hepatocellular carcinoma cell invasion and metastasis by regulating Atg5-mediated autophagy. +target gene 35117758 hsa-mir-152 Stomach Neoplasms H19/miR-152-3p/TCF4 axis increases chemosensitivity of gastric cancer cells through suppression of epithelial-mesenchymal transition. +circulation_biomarker_prognosis_ns 35117730 hsa-mir-10a Laryngeal Neoplasms Lower serum level of microRNA-21 and higher serum level of microRNA-10a predict better prognosis in LSCC patients. +circulation_biomarker_prognosis_ns 35117730 hsa-mir-21 Laryngeal Neoplasms CONCLUSIONS: The serum levels of microRNA-21 and microRNA-10a are associated with long-term prognosis in laryngeal cancer patients. +target gene 35117718 hsa-mir-567 Stomach Neoplasms The miR-567/RPL15/TGF-β/Smad axis inhibits the stem-like properties and chemo-resistance of gastric cancer cells. +genetics_overexpression_promote 35117716 hsa-mir-106a Prostatic Neoplasms Overexpression of miR-106a in PCa cells triggered cell apoptosis and suppressed cell proliferation, migration, and invasion. +lncRNA target 35117684 hsa-mir-4428 Uterine Cervical Neoplasms CONCLUSIONS: RGMB-AS1 regulated miR-4428/PBX1 axis to aggravate CC development, indicating that targeting RGMB-AS1 could be a potent way for developing the novel therapeutic methods for CC patients. +lncRNA target 35117649 hsa-mir-28 Colonic Neoplasms 5p plays an important role in ferroptosis by targeting N4BP1 and could serve as a potential therapeutic approach for colon cancer. +target gene 35117640 hsa-mir-378 Colorectal Neoplasms MicroRNA-124 and microRNA-378 inhibit the proliferation and invasion of colorectal cancer by upregulating KiSS1. +target gene 35117640 hsa-mir-124 Colorectal Neoplasms MicroRNA-124 and microRNA-378 inhibit the proliferation and invasion of colorectal cancer by upregulating KiSS1. +genetics_knock down_promote 35117631 hsa-mir-181 Osteosarcoma CONCLUSIONS: IL-1beta secreted by M2-TAMs contributed to OS metastasis, which could be suppressed by knockdown of miR-181alpha-5p or overexpression of RASSF1A through NF-kappaB/miR-181alpha-5p/RASSF1A/Wnt pathway. +lncRNA target 35117624 hsa-mir-216a Adenocarcinoma of Lung Rescue experiment showed that miR-216a-3p inhibitor promoted cell viability, migration and invasion, and inhibited apoptosis of lung adenocarcinoma cells, partly reversed the effects of siCOPB2. CONCLUSIONS: High-expressed COPB2 promotes metastasis and inhibits apoptosis of lung adenocarcinoma cells through functioning as a target of miR-216a-3p. +other 35117623 hsa-mir-491 Colorectal Neoplasms Interaction between linc01615 and miR-491-5p regulates the survival and metastasis of colorectal cancer cells. +exosome 35117617 hsa-mir-29b Carcinoma, Hepatocellular Exosomal miR-29b from cancer-associated fibroblasts inhibits the migration and invasion of hepatocellular carcinoma cells. +lncRNA target 35117607 hsa-mir-124 Bulimia Nervosa This study was designed to study whether denosumab inhibits human BC cells (MCF-7) cell line-induced spontaneous osteoclastogenesis via RANKL/metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)/miR-124 axis. +lncRNA target 35117607 hsa-mir-124 Adenocarcinoma This study was designed to study whether denosumab inhibits human BC cells (MCF-7) cell line-induced spontaneous osteoclastogenesis via RANKL/metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)/miR-124 axis. +genetics_overexpression_suppress 35117532 hsa-mir-193b Tongue Neoplasms MiR-193b-5p mimics were transfected into tongue cancer cell lines CAL27 and TCA-8113 to generate miR-193b-5p overexpression cells. +target gene 35117528 hsa-mir-574 Pancreatic Neoplasms LncRNA FAM66C inhibits pancreatic cancer progression by sponging miR-574-3p. +target gene 35117524 hsa-mir-26a Carcinoma, Non-Small-Cell Lung miRNA-26a blocks interleukin-2-mediated migration and proliferation of non-small cell lung cancer cells via vascular cell adhesion molecule-1. +lncRNA target 35117516 hsa-mir-93 Urinary Bladder Neoplasms CONCLUSIONS: lncRNA MEG3 could function as a competing endogenous RNA of miR-93 to regulate the tumorigenesis of BC via PI3K/AKT/mTOR pathway. +transcription factor target 35117503 hsa-mir-378a Carcinoma, Hepatocellular CONCLUSIONS: miR-378a-5p improved the HCC prognosis and suppressed HCC progression by targeting the VEGF pathway. +other 35117497 hsa-mir-877 Multiple Myeloma 3p and let-7a-5p may serve as novel biomarkers for RI risk in MM patients. +other 35117497 hsa-mir-449c Multiple Myeloma 3p and let-7a-5p may serve as novel biomarkers for RI risk in MM patients. +other 35117497 hsa-mir-449c Kidney Diseases 3p and let-7a-5p may serve as novel biomarkers for RI risk in MM patients. +other 35117497 hsa-mir-103a Multiple Myeloma 3p and let-7a-5p may serve as novel biomarkers for RI risk in MM patients. +other 35117497 hsa-mir-877 Kidney Diseases 3p and let-7a-5p may serve as novel biomarkers for RI risk in MM patients. +other 35117497 hsa-mir-103a Kidney Diseases 3p and let-7a-5p may serve as novel biomarkers for RI risk in MM patients. +other 35117497 hsa-let-7a Kidney Diseases 3p and let-7a-5p may serve as novel biomarkers for RI risk in MM patients. +other 35117497 hsa-let-7a Multiple Myeloma 3p and let-7a-5p may serve as novel biomarkers for RI risk in MM patients. +other 35117497 hsa-mir-455 Multiple Myeloma 3p and let-7a-5p may serve as novel biomarkers for RI risk in MM patients. +other 35117497 hsa-mir-455 Kidney Diseases 3p and let-7a-5p may serve as novel biomarkers for RI risk in MM patients. +circulation_biomarker_diagnosis_up 35117494 hsa-mir-643 Thyroid Cancer, Papillary Patients with larger diameter tumors or moderate-poorly differentiated tumors were more likely to have higher miR-643 expression levels in both PTC tissue and serum. +target gene 35117490 hsa-mir-185 Pancreatic Neoplasms LncRNA XIST acts as a ceRNA sponging miR-185-5p to modulate pancreatic cancer cell proliferation via targeting CCND2. +circulation_biomarker_prognosis_down 35117475 hsa-mir-596 Stomach Neoplasms The MTT assay assessed MNK28 and SGC7901 cell proliferation after transfection with miR-596 plasmids. +lncRNA target 35117454 hsa-mir-148b Endometrial Neoplasms Importantly, we determined that DNMT1 is a target gene of miR-148b in EC cells, and silencing of DNMT1 reversed the effects of miR-148b inhibitor on cell proliferation, cell cycle progression, and apoptosis in EC. +lncRNA target 35117441 hsa-mir-543 Nasopharyngeal Carcinoma RESULTS: The results showed that MEG3 was decreased and miR-543 was increased in NPC cell lines, and upregulated MEG3 inhibited cell proliferation, migration, and invasion and promoted apoptosis, suggesting that MEG3 acts as a tumor suppressor in NPC cells. +other 35117431 hsa-mir-4284 Prostatic Neoplasms Two miRNAs (hsa-miR-428 and hsa-miR-4284) involve in PCa by regulating BMP5-BAMBI interaction and TGF-beta signaling pathway. +other 35117431 hsa-mir-428 Prostatic Neoplasms Two miRNAs (hsa-miR-428 and hsa-miR-4284) involve in PCa by regulating BMP5-BAMBI interaction and TGF-beta signaling pathway. +other 35117416 hsa-mir-24 Urinary Bladder Neoplasms microRNA-324 plays an oncogenic role in bladder cancer cell growth and motility. +other 35117412 hsa-mir-425 Carcinoma, Endometrioid Eleven mRNAs, 3 miRNAs (has-mir-425, has-mir-211 and has-mir-301b) and 6 lncRNAs (AC11049.1, ADARB2-AS1, C10orf91, GLIS3-AS1, LINC00237 and LINC00261) were found to be significantly correlated with overall survival in UCEC (P value <0.05). +other 35117412 hsa-mir-425 Uterine Neoplasms Eleven mRNAs, 3 miRNAs (has-mir-425, has-mir-211 and has-mir-301b) and 6 lncRNAs (AC11049.1, ADARB2-AS1, C10orf91, GLIS3-AS1, LINC00237 and LINC00261) were found to be significantly correlated with overall survival in UCEC (P value <0.05). +other 35117412 hsa-mir-211 Carcinoma, Endometrioid Eleven mRNAs, 3 miRNAs (has-mir-425, has-mir-211 and has-mir-301b) and 6 lncRNAs (AC11049.1, ADARB2-AS1, C10orf91, GLIS3-AS1, LINC00237 and LINC00261) were found to be significantly correlated with overall survival in UCEC (P value <0.05). +other 35117412 hsa-mir-211 Uterine Neoplasms Eleven mRNAs, 3 miRNAs (has-mir-425, has-mir-211 and has-mir-301b) and 6 lncRNAs (AC11049.1, ADARB2-AS1, C10orf91, GLIS3-AS1, LINC00237 and LINC00261) were found to be significantly correlated with overall survival in UCEC (P value <0.05). +other 35117358 hsa-mir-504 Uterine Cervical Neoplasms HPV16 E6 regulates the proliferation, invasion, and apoptosis of cervical cancer cells by downregulating miR-504. +other 35117327 hsa-mir-449a Esophageal Squamous Cell Carcinoma Down-regulation of miR-449a-5p promoted the proliferation of ESCC cells. +other 35117327 hsa-mir-449a Esophageal Neoplasms Down-regulation of miR-449a-5p promoted the proliferation of ESCC cells. +target gene 35117325 hsa-mir-143 Urinary Bladder Neoplasms Long noncoding RNA MAFG-AS1 facilitates bladder cancer tumorigenesis via regulation of miR-143-3p/SERPINE1 axis. +target gene 35117305 hsa-mir-185 Stomach Neoplasms MiR-185-3p regulates epithelial mesenchymal transition via PI3K/Akt signaling pathway by targeting cathepsin D in gastric cancer cells. +genetics_GWAS 35117288 hsa-mir-146a Lung Neoplasms RESULTS: In conclusion, the frequency of miR-146a GC genotype mutation in normal people and patients with lung cancer is 44% and 47% respectively and the rate of miR-146a CC genotype mutation in the normal people and patients with lung cancer is 17% and 22% respectively. What's more, the frequency of miR-146a C allele mutation in normal people and patients with lung cancer is 40% and 46% respectively. +target gene 35117240 hsa-mir-137 Stomach Neoplasms EDIL3 regulates gastric cancer cell migration, invasion and epithelial-mesenchymal transition via TGF-β1/XIST/miR-137 feedback loop. +other 35117225 hsa-mir-34a Leukemia, Lymphocytic, Chronic, B-Cell Up-regulated expression of miR-34a or down-regulated expression of MDM4 could increase apoptosis of CLL cells +lncRNA target 35117177 hsa-mir-21 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: These results indicated that BMSCs could blocked the proinflammatory pathway of macrophage through miR-21 over-expression, thus could be a potential therapeutic strategy for RILI. +circulation_biomarker_prognosis_ns 35117168 hsa-mir-138 Stomach Neoplasms 5p expression in cancer tissues or plasma could be a useful predictive biomarker for the efficacy of platinum-based chemotherapy and prognoses in advanced gastric cancer patients. +other 35117163 hsa-mir-486 Carcinoma, Non-Small-Cell Lung miR-486 could be used as an unfavorable prognostic biomarker for NSCLC patients. +transcription factor target 35117048 hsa-mir-29c Colorectal Neoplasms Last but not least, we analyzed the TargetScan dataset and found that Girdin was a regulated target of hsa-miR-29c-3p in CRC. CONCLUSIONS: Our fi ndings suggest that Girdin has a crucial role in CRC progression via miR-29c-3p/Girdin axis, highlighting Girdin as a therapeutic target for CRC. +target gene 35117036 hsa-mir-203a Esophageal Neoplasms miR-203a-3p regulates the cellular processes of esophageal cancer cells via targeting CtBP2. +target gene 35117034 hsa-mir-145 Colonic Neoplasms LncRNA CASC9 regulates cell proliferation, apoptosis and cell cycle via sponging miR-145-5p in colon cancer cells. +other 35117029 hsa-mir-200c Urinary Bladder Neoplasms MicroRNA-200c affects bladder cancer angiogenesis by regulating the Akt2/mTOR/HIF-1 axis. +other 35117027 hsa-mir-4705 Stomach Neoplasms Furthermore, hsa-mir-4705 (miRNA) and BMPR1B (mRNA) at the downstream of hsa_circ_0067934 were found differentially expressed in gastric cancer by expression data from TCGA database. Moreover, we discovered that the hsa_circ_0067934/hsa-mir-4705/BMPR1B axis might be involved in the carcinogenesis of gastric cancer. +genetics_knock down_promote 35117016 hsa-mir-139 Colonic Neoplasms 5p were found in circ-STAT3.46 knockdown cells. +genetics_knock down_promote 35117009 hsa-mir-505 Leukemia, Myeloid, Acute CONCLUSIONS: Lnc-MVIH knockdown inhibits cell proliferation but promotes cell apoptosis via regulating miR-505 mediated HMGB1 and CCNE2 in AML. +target gene 35116999 hsa-mir-497 Carcinoma, Non-Small-Cell Lung MicroRNA-497-5p negatively regulates the proliferation and cisplatin resistance of non-small cell lung cancer cells by targeting YAP1 and TEAD1. +epigenetics 35116985 hsa-mir-34a Osteosarcoma The regulatory role of aberrant methylation of microRNA-34a promoter CpGs in osteosarcoma. +lncRNA target 35116967 hsa-mir-29b Adrenocortical Carcinoma Finally, through Kaplan-Meier survival analysis, we identified five lncRNAs (LINC00887, MEIS1-AS2, MIR29B2CHG, MIR503HG, and SREBF2-AS1) associated with prognosis in patients with ACC. +lncRNA target 35116967 hsa-mir-503 Adrenocortical Carcinoma Finally, through Kaplan-Meier survival analysis, we identified five lncRNAs (LINC00887, MEIS1-AS2, MIR29B2CHG, MIR503HG, and SREBF2-AS1) associated with prognosis in patients with ACC. +lncRNA target 35116964 hsa-mir-101 Carcinoma, Non-Small-Cell Lung 3p/ROCK2 signaling in cisplatin resistance of NSCLC cells. +target gene 35116952 hsa-mir-204 Melanoma MicroRNA-204-3p modulates epithelial-mesenchymal transition by targeting paired box gene 2 in human melanoma A-375 cells. +target gene 35116927 hsa-let-7a Breast Neoplasms MicroRNA let-7a inhibits proliferation of breast cancer cell by downregulating USP32 expression. +other 35116921 hsa-mir-21 Thyroid Cancer, Papillary Multivariate logistic regression confirmed the association between miR-138/miR-21 expression and PTC diagnosis. +other 35116921 hsa-mir-138 Thyroid Cancer, Papillary METHODS: miR-138/miR-21 expression was tested in 101 PTC and 51 benign thyroid nodule (control) patients using quantitative real-time PCR. +other 35116873 hsa-mir-21 Carcinoma, Hepatocellular BACKGROUND: This study was conducted to investigate the effects of c[RGDyk]-coated liposomes loaded with Adriamycin (nanodrug) and miR-21 mimics on hepatoma cell line SMCC-7721. +lncRNA target 35116871 hsa-mir-221 Colonic Neoplasms To uncover potential targets for treatment, the present study investigated PDZRN4 in colon cancer development, and explored the role of miR +lncRNA target 35116858 hsa-mir-222 Thyroid Cancer, Papillary CONCLUSIONS: The identified altered miRNAs (hsa-mir-222, hsa-mir-221, hsa-mir-214, hsa-mir2 and hsa-mir-34a) and their target mRNAs (BCL2, BCL2L11 and PEG3, ALDH1A1, PLA2R1, TFCP2L1, RAB23, TK1 and CTSB) may be helpful in understanding the molecule mechanism of follicular variant of papillary thyroid carcinoma. +lncRNA target 35116858 hsa-mir-214 Thyroid Cancer, Papillary CONCLUSIONS: The identified altered miRNAs (hsa-mir-222, hsa-mir-221, hsa-mir-214, hsa-mir2 and hsa-mir-34a) and their target mRNAs (BCL2, BCL2L11 and PEG3, ALDH1A1, PLA2R1, TFCP2L1, RAB23, TK1 and CTSB) may be helpful in understanding the molecule mechanism of follicular variant of papillary thyroid carcinoma. +lncRNA target 35116858 hsa-mir-34a Thyroid Cancer, Papillary CONCLUSIONS: The identified altered miRNAs (hsa-mir-222, hsa-mir-221, hsa-mir-214, hsa-mir2 and hsa-mir-34a) and their target mRNAs (BCL2, BCL2L11 and PEG3, ALDH1A1, PLA2R1, TFCP2L1, RAB23, TK1 and CTSB) may be helpful in understanding the molecule mechanism of follicular variant of papillary thyroid carcinoma. +lncRNA target 35116858 hsa-mir-138-2 Thyroid Cancer, Papillary CONCLUSIONS: The identified altered miRNAs (hsa-mir-222, hsa-mir-221, hsa-mir-214, hsa-mir2 and hsa-mir-34a) and their target mRNAs (BCL2, BCL2L11 and PEG3, ALDH1A1, PLA2R1, TFCP2L1, RAB23, TK1 and CTSB) may be helpful in understanding the molecule mechanism of follicular variant of papillary thyroid carcinoma. +lncRNA target 35116858 hsa-mir-221 Thyroid Cancer, Papillary CONCLUSIONS: The identified altered miRNAs (hsa-mir-222, hsa-mir-221, hsa-mir-214, hsa-mir2 and hsa-mir-34a) and their target mRNAs (BCL2, BCL2L11 and PEG3, ALDH1A1, PLA2R1, TFCP2L1, RAB23, TK1 and CTSB) may be helpful in understanding the molecule mechanism of follicular variant of papillary thyroid carcinoma. +lncRNA target 35116852 hsa-mir-17 Colonic Neoplasms Furthermore, the Wnt/beta-catenin signaling, activated by miR-17 and miR-18a, was required for the oncogenic role of MIR17HG in colon cancer. CONCLUSIONS: MIR17HG mediated upregulation of miR-17 and miR-18a promotes the progression of colon cancer via activating Wnt/beta-catenin signaling. +lncRNA target 35116852 hsa-mir-18a Colonic Neoplasms Furthermore, the Wnt/beta-catenin signaling, activated by miR-17 and miR-18a, was required for the oncogenic role of MIR17HG in colon cancer. CONCLUSIONS: MIR17HG mediated upregulation of miR-17 and miR-18a promotes the progression of colon cancer via activating Wnt/beta-catenin signaling. +lncRNA target 35116817 hsa-mir-1 Carcinoma, Non-Small-Cell Lung Moreover, in consideration of the meta-analysis, 1,012 clinical specimens were systematically analyzed via meta-analysis, clinical specimens were systematically analyzed via meta-analysis, and the results showed that the expression of miR +target gene 35116797 hsa-mir-451 Prostatic Neoplasms MiR-451 suppresses the growth, migration, and invasion of prostate cancer cells by targeting macrophage migration inhibitory factor. +genetics_overexpression_promote 35116795 hsa-mir-210 Carcinoma, Hepatocellular Moreover, miR-210 overexpression prevented the effects of cisplatin and rescued HCC cell growth, and miR-210 inhibition contributed to improved chemosensitivity of cisplatin in HCC cells. +genetics_overexpression_promote 35116786 hsa-mir-1290 Chordoma RESULTS: In vitro functional analysis, including clone formation, and Transwell assays indicated overexpression of miR-1290 significantly suppressed chordoma cell proliferation and invasion. +target gene 35116709 hsa-mir-23a Carcinoma, Non-Small-Cell Lung Long non-coding RNA ZNF674-AS1 regulates miR-23a/E-cadherin axis to suppress the migration and invasion of non-small cell lung cancer cells. +lncRNA target 35116702 hsa-mir-134 Pulmonary Disease, Chronic Obstructive 5p and miR-146a-5p conferred protection against TNF-alpha-induced mucus hypersecretion through repressing NF-kappaB and p38 MAPK signaling, indicating that miR +lncRNA target 35116702 hsa-mir-146a Pulmonary Disease, Chronic Obstructive 5p and miR-146a-5p conferred protection against TNF-alpha-induced mucus hypersecretion through repressing NF-kappaB and p38 MAPK signaling, indicating that miR +other 35116678 hsa-mir-204 Colorectal Neoplasms Downregulating miR-204 expression plays a vital role in upregulating ANGPTL2 expression and promoting the pathogenesis of CRC. +genetics_overexpression_promote 35116677 hsa-mir-16 Carcinoma, Non-Small-Cell Lung 5p were overturned by overexpression of DLX6-AS1 or BMI1 in NSCLC cells. +lncRNA target 35116675 hsa-mir-137 Uterine Cervical Neoplasms CONCLUSIONS: MiR-137 targets Notch1 and regulates CC through the PI3K/Akt/mTOR pathway. +genetics_knock down_suppress 35116658 hsa-mir-138 Colorectal Neoplasms We also found that the level of SIRT1 in CRC tissues and cell lines is higher, and through Dual-luciferase reporter assay, we found that SIRT1 is a new target of miR-138 in CRC, and SIRT1 knockdown could inhibit CRC proliferation, migration and invasion in vitro. +target gene 35116655 hsa-mir-339 Stomach Neoplasms MiRNA-339 targets and regulates ZNF689 to inhibit the proliferation and invasion of gastric cancer cells. +circulation_biomarker_prognosis_ns 35116650 hsa-mir-27a Carcinoma, Non-Small-Cell Lung Serum miR-27a is a biomarker for the prognosis of non-small cell lung cancer patients receiving chemotherapy. +other 35116608 hsa-mir-134 Carcinoma, Hepatocellular CONCLUSIONS: In summary, propofol appears to upregulate the expression level of miR-134, decrease the BCL-2 level, and induce HCC cell apoptosis by promoting the cleaved caspase-3 expression level. +genetics_overexpression_promote 35116581 hsa-mir-19a Esophageal Squamous Cell Carcinoma CONCLUSIONS: Overexpression of miR-19a-3p increased the invasion and migration of ESCC cells via the RAC1/CDC42-PAK1 pathway, suggesting that this pathway mediates the effect of miR-19a-3p on promoting LNM in ESCC. +transcription factor target 35116553 hsa-mir-7 Carcinoma, Ovarian Epithelial The evidence showed that miR7 functioning as a tumor suppressor gene in EOC. +other 35116508 hsa-mir-138 Glioma In summary, the CircWEE1/miR-138 axis may regulate SIRT1 to promote malignant progression in glioma. +circulation_biomarker_diagnosis_ns 35116507 hsa-mir-126 Mesothelioma, Malignant Considering that the available studies have a high risk of bias, further rigorous studies are needed to assess the diagnostic value of circulating miR-126 for MPM. +target gene 35116505 hsa-mir-30 Carcinoma, Hepatocellular 3p may inhibit AQP9 expression in HCC. +target gene 35116505 hsa-mir-23a Carcinoma, Hepatocellular 3p may inhibit AQP9 expression in HCC. +target gene 35116434 hsa-mir-221 Glioblastoma MicroRNA-221 promotes tumor progression by targeting HHIP in human glioblastoma. +genetics_overexpression_suppress 35116432 hsa-mir-19a Multiple Myeloma The effects of miR-19a-3p on cell proliferation, migration, and invasion in U226 and RPMI-8226 MM cells were evaluated by miR-19a-3p overexpression. +circulation_biomarker_diagnosis_ns 35116424 hsa-mir-210 Carcinoma, Hepatocellular MCP-1 and miR-210 levels were measured in 40 HCC patients at baseline before TACE and compared with 17 healthy controls by immunoassay and reverse transcriptase quantitative polymerase chain reaction (RT-qPCR). RESULTS: The serum MCP-1 and miR-210 levels were significantly elevated in HCC patients compared to healthy subjects. +lncRNA target 35116405 hsa-mir-516b Retinoblastoma Moreover, TUG1 could bind with miR-516b-5p, which targeted H6PD in RB. +circulation_biomarker_prognosis_up 35116367 hsa-mir-203 Esophageal Squamous Cell Carcinoma Moreover, the serum level of miR-25/miR-203 in 57 ESCC patients was higher than that in 31 healthy volunteers. +circulation_biomarker_prognosis_up 35116367 hsa-mir-25 Esophageal Squamous Cell Carcinoma Moreover, the serum level of miR-25/miR-203 in 57 ESCC patients was higher than that in 31 healthy volunteers. +target gene 35116366 hsa-mir-625 Carcinoma, Non-Small-Cell Lung Long non-coding RNA LINC00511 promotes proliferation, invasion, and migration of non-small cell lung cancer cells by targeting miR-625-5p/GSPT1. +other 35116358 hsa-mir-29a Breast Neoplasms Furthermore, we first predicted miR-29a-3p was a potential upstream regulator of SETDB1 in BRCA. CONCLUSIONS: This study suggested that miR-29a-3p can mediate the expression of SETDB1 with poor prognosis and tumor immune infiltration in BRCA. +transcription factor target 35116342 hsa-mir-425 Lymphoma, Large B-Cell, Diffuse 5p is responsible for the oncogenic progression and relapse of DLBC tumorigenesis via PTEN/PI3K signaling, which can thus be effectively used to achieve better therapeutic outcomes. +target gene 35116341 hsa-mir-20a Ovarian Neoplasms LINC00641 inhibits the proliferation and invasion of ovarian cancer cells by targeting miR-320a. +other 35116336 hsa-mir-15a Carcinoma, Endometrioid Furthermore, the expression of miR-15a-5p was significantly decreased in endometrial cancer patients with recurrence or metastasis and thus, miR-15a-5p may have certain value in predicting postoperative recurrence or metastasis in such patients. +target gene 35116334 hsa-mir-199a Breast Neoplasms Dexmetomidine promotes the activity of breast cancer cells through miR-199a/HIF-1α axis. +other 35116328 hsa-mir-218 Glioblastoma C10orf25/miR-218/DCBLD2 may be an important regulatory pathway in GBM. C10orf25/miR-218/DCBLD2 may be an important regulatory pathway associated with the pathogenesis of GBM. +lncRNA target 35116306 hsa-mir-10b Carcinoma, Renal Cell CONCLUSIONS: Our findings suggest that SNHG3 plays a vital role in promoting ccRCC via the microRNA-10b-5p/BIRC5 axis and may serve as a novel therapeutic target for the treatment of patients with ccRCC. +other 35116269 hsa-mir-3176 lung squamous cell carcinoma RESULTS: Firstly, we found that three miRNAs, including hsa-miR-2278, hsa-miR-3176 and hsa-miR-3654 formed the core of ceRNA network of lung squamous cell carcinoma. +other 35116269 hsa-mir-2278 lung squamous cell carcinoma RESULTS: Firstly, we found that three miRNAs, including hsa-miR-2278, hsa-miR-3176 and hsa-miR-3654 formed the core of ceRNA network of lung squamous cell carcinoma. +other 35116269 hsa-mir-654 lung squamous cell carcinoma RESULTS: Firstly, we found that three miRNAs, including hsa-miR-2278, hsa-miR-3176 and hsa-miR-3654 formed the core of ceRNA network of lung squamous cell carcinoma. +other 35116241 hsa-mir-196b Adenocarcinoma of Lung We observe that lncRNA (ADAMTS9-AS2, TEX41, DLEU2, LINC00152)-miR3p-SCARB1 and hsa_circ_0000053-miR-196a-5p/miR-196b-5p-HOXA5 ceRNA networks might play an important role in bone metastasis of Xuanwei LuAC. +other 35116241 hsa-mir-223 Adenocarcinoma of Lung We observe that lncRNA (ADAMTS9-AS2, TEX41, DLEU2, LINC00152)-miR3p-SCARB1 and hsa_circ_0000053-miR-196a-5p/miR-196b-5p-HOXA5 ceRNA networks might play an important role in bone metastasis of Xuanwei LuAC. +other 35116241 hsa-mir-196a Adenocarcinoma of Lung We observe that lncRNA (ADAMTS9-AS2, TEX41, DLEU2, LINC00152)-miR3p-SCARB1 and hsa_circ_0000053-miR-196a-5p/miR-196b-5p-HOXA5 ceRNA networks might play an important role in bone metastasis of Xuanwei LuAC. +lncRNA target 35116239 hsa-mir-133b Colorectal Neoplasms The result of our previous research has found a statistically significant downregulation of microRNA-133b expression in human CRC cells, microRNA-133b can block the growth and metastatic progression of CRC cells in vitro and in vivo by targeting and repressing mesenchymal to epithelial transition factor. +other 35116078 hsa-mir-138 Hypertension, Pulmonary Furthermore, bioinformatics and Luciferase assay showed that circWDR37 directly sponged hsa-miR5p (miR-138) and was involved in the immunoregulatory and inflammatory processes of PAH. +lncRNA target 35116071 hsa-mir-32 Colonic Neoplasms 5p/PER2/CRY2 regulatory axis in COAD was also detected through a mRNA-miRNA-lncRNA network. +circRNA target 35116004 hsa-mir-144 Diabetes Mellitus, Type 2 CONCLUSION: hsa_circ_0111707 is associated with risk of T2D development via sponging miR3p. +exosome 35115831 hsa-mir-204 Ovarian Neoplasms Exosomal lncRNA ATB Derived from Ovarian Cancer Cells Promotes Angiogenesis via Regulating miR-204-3p/TGFβR2 Axis. +circulation_biomarker_prognosis_up 35115787 hsa-mir-362 Nasopharyngeal Carcinoma 3p expression was decreased in the serum and tissues of NPC patients and had diagnostic value for screening NPC. +genetics_overexpression_promote 35115487 hsa-mir-214 Squamous Cell Carcinoma of Head and Neck Notably, overexpression of LINC01123 or B7-H3 or downregulation of miR +other 35114922 hsa-mir-335 Alzheimer Disease The topological analyses of the constructed regulatory networks suggested that TF - FOXC1 and miRNA - hsa-mir5p might be vital co-regulators of gene expression in AD and epilepsy. +other 35114922 hsa-mir-335 Epilepsy The topological analyses of the constructed regulatory networks suggested that TF - FOXC1 and miRNA - hsa-mir5p might be vital co-regulators of gene expression in AD and epilepsy. +circRNA target 35114894 hsa-mir-98 Cerebral Infarction, Acute Furthermore, acyl-CoA synthetase long-chain family member 4 (ACSL4) was confirmed to be a downstream target of miR +genetics_overexpression_promote 35114891 hsa-mir-1294 Carcinoma, Non-Small-Cell Lung And circPLK1 overexpression facilitates the progression of NSCLC by negatively regulating miR-1294 level and maintaining a high-level expression of HMGA1 (High Mobility Group Protein A1). Our study suggests that circPLK1 upregulation plays an important role in NSCLC progression by targeting miR-1294/HMGA1 axis. +virus_miRNA 35114606 ebv-mir-BHRF1-2 Multiple Sclerosis ebv-miR-BHRF1-2-5p directly targeting MALT1 +virus_miRNA 35114606 ebv-mir-BART11 Multiple Sclerosis ebv-miR-BART11 directly targeting FOXP1 +genetics_overexpression_promote 35114192 hsa-mir-6874 Osteosarcoma 3p overexpression markedly inhibited the progression of OS cells. +other 35114139 hsa-mir-9 Inflammation The present study aimed to investigate the expression of miR9 and its correlation with cytokines, proteolytic enzymes and apoptosis in an experimental model of 6-mer HA induced inflammation in human chondrocytes. We suggested that the up regulation of miR9, induced by 6-mer HA, could be a cellular attempt to limit cell damage during inflammation. +lncRNA target 35113786 hsa-mir-628 Glioma 5p in glioma cells as the biological functions of DLGAP1-AS1 are partially mediated via miR +other 35113418 hsa-mir-18 Myocardial Infarction 5p) in myocardial infarction (MI) and its potential mechanism. +transcription factor target 35113417 hsa-mir-486 Myocardial Ischemia Therefore, miR-486 may become a new target for myocardial IRI therapy. +transcription factor target 35113417 hsa-mir-486 Iris Diseases Therefore, miR-486 may become a new target for myocardial IRI therapy. +transcription factor target 35113040 hsa-mir-29 Leiomyoma Furthermore, miR-29 inhibitors promoted the protein expression of MMP-2 and MMP-9 (P < 0.01), and EMT promoting proteins N-cadherin, snail, vimentin, and Transwell assay showed that miR-29 inhibitors promoted cell migration in uterine leiomyoma (P < 0.01). +genetics_knock down_suppress 35113007 hsa-mir-193a Squamous Cell Carcinoma of Head and Neck In conclusion, these findings suggest that knockdown of AGAP2-AS1 inhibited the proliferation and invasion of LSCC cells through regulating the miR-193a-3p/LOXL4 axis. +lncRNA target 35113000 hsa-mir-146a Cerebral Hemorrhage All the effects of MALAT1-shRNA on ICH rats were reversed by miR-146a inhibitor co-treatment. +genetics_knock down_promote 35112991 hsa-mir-1225 Breast Neoplasms 3p overexpression worked oppositely. +lncRNA target 35112985 hsa-mir-190a Uterine Cervical Neoplasms KLF6 was a target of miR-190a-3p and inhibited miR-190a-3p-induced CC tumor growth. +lncRNA target 35112982 hsa-mir-19a Osteosarcoma Furthermore, we found that miR-19a-3p might exert its oncogenic function by inhibiting PHLDA3 expression in osteosarcoma. These results demonstrated miR-19a-3p/ PHLDA3/ Akt/GSK3beta axis has a pivotal role in osteosarcoma, and PHLDA3 is a prospective therapeutic target for treating osteosarcoma. +lncRNA target 35112981 hsa-mir-146a Sepsis Therefore, GAS5 is downregulated in sepsis-ALI and inhibits cell apoptosis by up-regulating the expression of miR-146a. +lncRNA target 35112981 hsa-mir-146a Acute Lung Injury Therefore, GAS5 is downregulated in sepsis-ALI and inhibits cell apoptosis by up-regulating the expression of miR-146a. +genetics_overexpression_suppress 35112979 hsa-mir-212 Arthritis, Rheumatoid In conclusion, TSPEAR-AS2 is downregulated in RA and its overexpression can decrease the apoptosis of RA HFLSs by downregulating miR +lncRNA target 35112970 hsa-mir-335 Sepsis Based on our results, it seemed that YY1-activated LINC00472 might contribute to SICD progression via the miR3p/MAOA pathway. +transcription factor target 35112252 hsa-mir-21 Carcinoma, Renal Cell 5p, a stimulator in RCC, and it deteriorated this cancer via repressing its downstream target gene ARHGAP24 expression. +circulation_biomarker_diagnosis_up 35111850 hsa-mir-148a Breast Neoplasms Serum levels of miR +circulation_biomarker_diagnosis_ns 35111850 hsa-mir-9 Breast Neoplasms Serum miR5p levels were markedly higher in patients with human epidermal growth factor receptor 2- (HER2-) positive breast cancer than in those with HER2-negative breast cancer (P = 0.049). +lncRNA target 35111808 hsa-let-7b Intervertebral Disc Degeneration Results suggested that NPSC-exo exacerbated cell degeneration of AFCs via let-7b-5p, accompanied by inhibition of IGF1R expression, and PI3K-Akt pathway activation. +lncRNA target 35111759 hsa-mir-223 Cardiotoxicity 3p mimic exhibits potential value in the treatment of RIHD. +other 35111747 hsa-mir-409 Parkinson Disease 3p in CSF as a diagnostic marker of PD. +circulation_biomarker_prognosis_up 35111539 hsa-mir-489 Cardiomyopathy, Dilated Additionally, the quantification of circulating miR-489 may have value as a potential prognostic marker for patients with DCM. +target gene 35111226 hsa-mir-652 Osteosarcoma miR-652 Inhibits the Proliferation, Migration, and Invasion of Osteosarcoma Cells by Targeting HOXA9 and Regulating the PI3K/Akt Signaling Pathway. +transcription factor target 35111054 hsa-mir-671 Wilms Tumor 5p) plays a crucial role in mediating beta-catenin-triggered podocyte injury by targeting Wilms tumor 1 (WT1). +lncRNA target 35111054 hsa-mir-671 Proteinuria Targeting miR +transcription factor target 35111054 hsa-mir-671 Nephrosclerosis In contrast, miR5p antagomir alleviated podocyte injury and attenuated proteinuria and renal fibrotic lesions after glomerular injury in vivo. +transcription factor target 35110471 hsa-mir-17 Acute Lung Injury FA inhibits PMVECs apoptosis induced by LPS via miR-17/PTEN to further regulate the activation of the PI3K/Akt pathway in ALI. +transcription factor target 35110470 hsa-mir-128 Neurotoxicity Syndromes 3p might be a potential therapeutic target for the prevention or treatment of sevoflurane-induced neurotoxicity by targeting with NOVA1. +transcription factor target 35110406 hsa-mir-27a Triple Negative Breast Neoplasms The DEL-derived pri-miR-27a ligand was cell active, potently and selectively inhibiting pri-miR-27a processing to reprogram gene expression and halt an otherwise invasive phenotype in triple-negative breast cancer cells. +lncRNA target 35109849 hsa-mir-506 Prostatic Neoplasms 3p is downregulated in prostate cancer cell lines and functions as a tumor suppressor. +epigenetics 35109842 hsa-mir-494 Breast Neoplasms DNMT1 induced methylation of MEG3 promoter, and played a key role in breast cancer growth through miR-494-3p/OTUD4 axis. +lncRNA target 35109802 hsa-mir-138 autosomal recessive congenital bilateral absence of vas deferens 5p can act as a positive regulator of osteogenic differentiation in CAVD patients to involve in inhibiting valve calcification, which is achieved through RUNX2 and Wnt/beta-catenin signaling pathway. +circulation_biomarker_diagnosis_ns 35109781 hsa-mir-192 Hepatitis B, Chronic 3p positively correlated with the serum levels of HBV DNA and HBsAg. +lncRNA target 35109756 hsa-mir-96 Coronary Artery Disease 5p would ameliorate AMI-associated cardiomyocytes injury by targeting BCL2L13, hence contributing to the clinical treatment of AMI-CAD. +lncRNA target 35109756 hsa-mir-96 Myocardial Infarction, Acute 5p would ameliorate AMI-associated cardiomyocytes injury by targeting BCL2L13, hence contributing to the clinical treatment of AMI-CAD. +transcription factor target 35108712 hsa-mir-126 Parkinson Disease CONCLUSION: Our results suggested that miR5p attenuated the neurotoxicity induced by MPP+ in vitro through targeting SP1 (Graphical abstract), which further enhanced our understanding of the pathological mechanism of PD. +circulation_biomarker_diagnosis_up 35108421 hsa-mir-448 Lupus Erythematosus, Systemic 3p level were observed in peripheral blood mononuclear cells (PBMCs) from SLE patients. +other 35108097 hsa-mir-573 Acute Lung Injury Our study provides a novel insight into miRmediated regulation of endothelial function during DENV2 infection, which can be further translated into a potential therapeutic and prognostic agent for severe dengue patients. +other 35108097 hsa-mir-573 Dengue Our study provides a novel insight into miRmediated regulation of endothelial function during DENV2 infection, which can be further translated into a potential therapeutic and prognostic agent for severe dengue patients. +lncRNA target 35107852 hsa-mir-206 Ovarian Neoplasms We tested the hypothesis that miR-206 and mir-26b, emerging onco-suppressors targeting PFKFB3 in estrogen-dependent tumors, would regulate proliferation and migration of serous epithelial ovarian cancer (EOC) cells via common glycolytic proteins, i.e., GLUT1 and PFKFB3, and downstream FAK. Overall, these results support the inverse relation between endogenous miRNA levels and their tumor-suppressive effects and suggest that restoring miR-206 expression represents a potential dual anti-PFKFB3/FAK strategy to control ovarian cancer progression. +lncRNA target 35107852 hsa-mir-26b Ovarian Neoplasms We tested the hypothesis that miR-206 and mir-26b, emerging onco-suppressors targeting PFKFB3 in estrogen-dependent tumors, would regulate proliferation and migration of serous epithelial ovarian cancer (EOC) cells via common glycolytic proteins, i.e., GLUT1 and PFKFB3, and downstream FAK. +lncRNA target 35107755 hsa-mir-194 Squamous Cell Carcinoma of Head and Neck 5p/MTFR1 axis promotes TGFbeta1-induced EMT, migration and invasion of cells in TSCC, which could be potential targets for treating TSCC patients. +lncRNA target 35107754 hsa-mir-29a Colorectal Neoplasms CBR3-AS1 is downregulated in CRC and inhibits miR-29a-mediated cell migration and invasion by sponging miR-29a. +other 35107490 hsa-mir-203a Pancreatic Carcinoma The miR-203a-3p is involved in the stimulation of epithelial-to-mesenchymal transition (EMT) and is related to worse OS in pancreatic cancer (TCGA data). +genetics_knock down_promote 35106926 hsa-mir-142 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: Circ-RAD23B knockdown inhibited NSCLC development by regulating the miR3p/MAP4K3 axis, which might be associated with the inactivation of the MAPK signaling pathway. +genetics_knock down_promote 35106879 hsa-mir-944 Carcinoma, Non-Small-Cell Lung Functionally, circ_0072088 knockdown improved CDDP sensitivity and repressed NSCLC cell malignancy, whereas miR-944 inhibitor hindered these effects. +lncRNA target 35106863 hsa-mir-125a Breast Neoplasms CONCLUSIONS: HOXA11-AS regulates the tumorigenic ability of BC via the miR-125a-5p/TMPRSS4 axis. +circulation_biomarker_prognosis_up 35106794 hsa-mir-183 Cholangiocarcinoma Finally, clinical data showed that up-regulated levels of plasma exosomal miR +other 35105862 hsa-mir-29a Brain Diseases We identified miR-29a-3p and miR3p as novel and robust contributors to cognitive trajectory independently of the eight known cerebral pathologies. +other 35105862 hsa-mir-132 Brain Diseases We identified miR-29a-3p and miR3p as novel and robust contributors to cognitive trajectory independently of the eight known cerebral pathologies. +other 35104452 hsa-mir-34c Cicatrix Here, we identify a p53-induced lncRNA suicidal PARP-1 cleavage enhancer (SPARCLE) adjacent to miR-34b/c required for p53-mediated apoptosis. +other 35104452 hsa-mir-34b Cicatrix Here, we identify a p53-induced lncRNA suicidal PARP-1 cleavage enhancer (SPARCLE) adjacent to miR-34b/c required for p53-mediated apoptosis. +other 35104050 hsa-mir-203 Myocardial Infarction, Acute CONCLUSIONS: miR3p availability is antagonized by Snhg8 for Postn and Vegfa-induced AMI progression. +circRNA target 35103839 hsa-mir-27a Osteoarthritis CONCLUSION: CircTMOD3 suppresses miR-27a maturation in OA to promote chondrocyte apoptosis induced by LPS. +circRNA target 35103833 hsa-mir-126 Carcinoma, Endometrioid 5p, negatively regulating MACC1 expression, was a functional target of circ_0002577 in EC cells. +lncRNA target 35103493 hsa-mir-140 Osteoarthritis CONCLUSION: CircSCAPER promoted IL-1beta-evoked ECM degradation, proliferation arrest, and apoptosis enhancement in chondrocytes via regulating miR3p/EZH2 axis, which gained a new insight into the pathogenesis of OA. +circulation_biomarker_diagnosis_ns 35103454 hsa-mir-21 Diabetic Nephropathies CONCLUSIONS: We suggest the potential of serum GDF15 and circulating-hsa-miR-21 to serve as clinically important biomarkers and therapeutic targets for controlling advancement of diabetes to DN. +circulation_biomarker_diagnosis_ns 35103454 hsa-mir-21 Diabetes Mellitus, Type 2 CONCLUSIONS: We suggest the potential of serum GDF15 and circulating-hsa-miR-21 to serve as clinically important biomarkers and therapeutic targets for controlling advancement of diabetes to DN. +other 35103365 hsa-mir-145 Squamous Cell Carcinoma of Head and Neck CONCLUSION: The expression profile and functions of miR-145 in canine oral SCC are similar to those in human HNSCC. +genetics_overexpression_promote 35103069 hsa-mir-10b Colorectal Neoplasms Rescue experiments showed that overexpressed miR-10b could reverse GAS5-mediated antitumor effect on CRC cells in vivo and in vitro. +genetics_overexpression_promote 35102025 hsa-mir-106b Esophageal Neoplasms miR-106b-5p mimics reversed the effect of CPEB3 overexpression on KYSE150 cells, and miR-106b-5p inhibitor reversed the effect of siRNA-CPEB3 on EC9706 cells. CPEB3 overexpressed by miR-106b-5p inhibition suppressed EC progression involved in EGFR and STAT3 signaling. +transcription factor target 35101688 hsa-mir-133a Carcinoma, Non-Small-Cell Lung Collectively speaking, luteolin inhibits the migration and invasion of NSCLC-VECs via miR-133a-3p/PURB- mediated MAPK and PI3K/Akt pathways. +other 35101680 hsa-mir-204 Li-Fraumeni Syndrome 5p were significantly downregulated. +other 35101680 hsa-mir-181a Li-Fraumeni Syndrome 5p were significantly downregulated. +other 35101680 hsa-mir-212 Li-Fraumeni Syndrome 5p were significantly downregulated. +other 35101680 hsa-mir-202 Li-Fraumeni Syndrome 5p were significantly downregulated. +other 35101680 hsa-mir-182 Li-Fraumeni Syndrome 5p were significantly downregulated. +other 35101680 hsa-mir-27a Li-Fraumeni Syndrome 5p were significantly downregulated. +other 35101080 hsa-mir-431 Colonic Neoplasms CONCLUSION: Taken together, the findings of the present study indicated that circCSPP1 may function as a competing endogenous RNA in the progression of colon cancer by regulating the miR-431/ROCK1 and miR-431/ZEB1 signaling axes. +genetics_knock down_promote 35101035 hsa-mir-138 Colorectal Neoplasms 5p could offset the repressed function of LINC00665 knockdown on CRC progression. +target gene 35100978 hsa-mir-503 Ovarian Neoplasms Repression of lncRNA PART1 attenuates ovarian cancer cell viability, migration and invasion through the miR-503-5p/FOXK1 axis. +exosome 35100464 hsa-mir-9 Squamous Cell Carcinoma of Head and Neck 5p inhibits TGF-beta signaling-mediated fibroblast phenotypic transformation through NOX4, which is related to the excellent prognosis of HPV patients. +genetics_overexpression_promote 35100092 hsa-mir-135b Colorectal Neoplasms Inhibition of miR-135b-5p in EVs or overexpression of FOXO1 partially reversed the effect of EVs on promoting COAD-induced angiogenesis. +circRNA target 35100091 hsa-mir-532 Glioma 3p/c-MET/PI3K/AKT axis is a potential treatment target for glioma. +lncRNA target 35100082 hsa-mir-130b Colorectal Neoplasms MiR-130b-3p promotes the progression and tumorigenesis of CRC at least partially by targeting CHD9.Abbreviations: CRC: Colorectal cancer; miR-130b-3p: microRNA 130b-3p; CHD9: chromodomain helicase DNA binding protein 9; UTR: untranslated region; FIT: fecal immunochemical test; AAs: advanced adenomas. +lncRNA target 35100080 hsa-mir-15b Osteosarcoma In conclusion, this study suggests that TRPM2-AS could promote OS cell malignancy by sponging miR-15b-5p/PPM1D axis. +genetics_overexpression_promote 35100076 hsa-mir-149 Stomach Neoplasms 5p overexpression limited the growth of GC tumors in vivo. +circRNA target 35099761 hsa-mir-192 Myocardial Infarction Circ-SWT1 ameliorates H(2)O(2)-induced apoptosis, oxidative stress and ER stress in cardiomyocytes via miR5p/SOD2 axis, suggesting the potential involvement of circ-SWT1 in AMI process. +genetics_overexpression_promote 35099637 hsa-mir-216b Endometrial Neoplasms Silencing LINC01354 or overexpressing miR-216b retarded EC cellular development. +exosome 35099348 hsa-mir-141 Liver Cirrhosis Transfer of circDIDO1 mediated by MSC-isolated exosomes suppressed HSC activation through the miR3p/PTEN/AKT pathway, gaining a new insight into the prevention of liver fibrosis in liver failure patients. +lncRNA target 35098480 hsa-mir-185 Ischemic Stroke These findings demonstrated that ADAMTS9-AS2 promoted angiogenesis through regulating miR5p/IGFBP-2 axis, suggesting that ADAMTS9-AS2 may be a potential marker for the diagnosis and treatment of neurological diseases. +genetics_knock down_promote 35098439 hsa-mir-34b Lymphoma, B-Cell Knockdown of Foxp1 partially reversed the effects of miR-34b-5p inhibitor on DLBCL cell proliferation and apoptosis. +circRNA target 35098413 hsa-mir-214 Glioma 5p and inhibited miR +circRNA target 35098410 hsa-mir-361 Stomach Neoplasms Our data showed that circ_0009910 might be a target for GC treatment, which could promote GC proliferation, metastasis, and glycolysis by the miR3p/SNRPA axis. +other 35098408 hsa-mir-520 Sepsis GAS5 regulated inflammatory response by the miR3p/SOCS3 axis in LPS-induced macrophages, which furnished a novel therapeutic idea in clinical treatment of inflammation-induced sepsis. +other 35098407 hsa-mir-187 Opium Dependence 5p in opioid use disorder. +other 35098407 hsa-mir-155 Opium Dependence 5p in opioid use disorder. +genetics_overexpression_promote 35097136 hsa-mir-338 Prostatic Neoplasms We found that most patients with prostate cancer overexpressed MMP-9; on the other hand, most of them underexpressed TIMP-1, RECK, and miR +lncRNA target 35097124 hsa-mir-548o Breast Neoplasms In this work, hsa_circ_0047604 expressed lower in breast cancer tissue and played the role of sponge of miR-548o. In conclusion, this study revealed that hsa_circ_0047604 acted as a tumor suppressor and regulated breast cancer progression via hsa_circ_0047604-miR-548o-DACH1 axis, which might provide a therapeutic method for breast cancer. +transcription factor target 35096965 hsa-mir-155 Neuralgia Venn analysis, target gene prediction analysis and functional enrichment analysis indicated several miRNAs (miR-200b-3p, miR-96, miR-182, miR-183, miR-30b, miR-155 and miR-145) and their target genes involved in known relevant pathways for NP. +transcription factor target 35096965 hsa-mir-182 Neuralgia Venn analysis, target gene prediction analysis and functional enrichment analysis indicated several miRNAs (miR-200b-3p, miR-96, miR-182, miR-183, miR-30b, miR-155 and miR-145) and their target genes involved in known relevant pathways for NP. +transcription factor target 35096965 hsa-mir-183 Neuralgia Venn analysis, target gene prediction analysis and functional enrichment analysis indicated several miRNAs (miR-200b-3p, miR-96, miR-182, miR-183, miR-30b, miR-155 and miR-145) and their target genes involved in known relevant pathways for NP. +transcription factor target 35096965 hsa-mir-96 Neuralgia Venn analysis, target gene prediction analysis and functional enrichment analysis indicated several miRNAs (miR-200b-3p, miR-96, miR-182, miR-183, miR-30b, miR-155 and miR-145) and their target genes involved in known relevant pathways for NP. +transcription factor target 35096965 hsa-mir-200b Neuralgia Venn analysis, target gene prediction analysis and functional enrichment analysis indicated several miRNAs (miR-200b-3p, miR-96, miR-182, miR-183, miR-30b, miR-155 and miR-145) and their target genes involved in known relevant pathways for NP. +transcription factor target 35096965 hsa-mir-145 Neuralgia Venn analysis, target gene prediction analysis and functional enrichment analysis indicated several miRNAs (miR-200b-3p, miR-96, miR-182, miR-183, miR-30b, miR-155 and miR-145) and their target genes involved in known relevant pathways for NP. +other 35096820 hsa-mir-122 Alcoholism We found that hepatocyte enriched miR-192 and miR-122 levels were significantly decreased in alcohol treated hepatocytes whereas their levels were increased in the cell-free supernatant. The primary transcripts of miR-192 and miR-122 were reduced in alcohol treated hepatocytes, suggesting alcohol partially affects these miRNAs at the transcriptional level. +exosome 35096820 hsa-mir-192 Carcinoma, Hepatocellular Inhibition of miR-192 in human hepatoma cells caused a significant increase in Rab27a, Rab35, syntaxin7 and syntaxin16 and a concurrent increase in exosome secretion, suggesting miR-192 regulates exosomes release in hepatocytes. +exosome 35096820 hsa-mir-192 Alcoholism Collectively, our results reveal that alcohol modulates Rabs, VAMPs and syntaxins directly and partly via miR-192 to induce exosome machinery and release. +exosome 35096570 hsa-mir-101 Colorectal Neoplasms HIPK3 Inhibition by Exosomal hsa-miR-101-3p Is Related to Metabolic Reprogramming in Colorectal Cancer. +genetics_knock down_suppress 35096564 hsa-mir-590 Urinary Bladder Neoplasms Interestingly, we demonstrated that MED10 interacts with and is co-expressed with the microRNA, hsa-miR-590, and that CRISPR-mediated knockout of MED10 elicits the downregulation of miR-590 preferentially in metastatic UC cells, compared to their primary tumor peers. CONCLUSION: These data provide preclinical evidence that dysregulated MED10/MIR590 signaling drives onco-aggression, disease progression, and recurrence of bladder UC and that this oncogenic signal is therapeutically actionable for repressing the metastatic/recurrent phenotypes, enhancing therapy response, and shutting down stemness-driven disease progression and relapse in patients with BLCA/UC. +lncRNA target 35096421 hsa-mir-338 Diabetic Nephropathies CONCLUSION: Circ-ADAM9 contributed to HG-induced ARPE9 cell injury by regulating miR3p/CARM1 axis, which provided effective targets for DR treatment. +other 35096344 hsa-let-7a Diabetes Mellitus Based on the obtained results in this study, the gene expression level of miRNA let-7a was lower in diabetic patients compared to healthy individuals in the group of control. +circulation_biomarker_prognosis_up 35096206 hsa-mir-125b Acute Kidney Injury Higher incidences of death and rehospitalization were observed in HF combined ARF cases expressing higher serum level of lncRNA ROR or lower level of miR-125b. +circulation_biomarker_prognosis_up 35096206 hsa-mir-125b Heart Failure Higher incidences of death and rehospitalization were observed in HF combined ARF cases expressing higher serum level of lncRNA ROR or lower level of miR-125b. +genetics_knock down_suppress 35096186 hsa-mir-146a Osteoporosis RESULTS: miR-146a-Exo administration presented the most potent effect on inhibition of pro-inflammatory cytokines production in high glucose-treated osteoclasts, restraint bone resorption, and restoration of the bone loss in streptozotocin-induced diabetic osteoporosis rats. +genetics_overexpression_promote 35096137 hsa-mir-124a Aortic Aneurysm, Abdominal Overexpressing miR-124a could effectively inhibit the proliferation and migration and promote the apoptosis of the AAA cells. +lncRNA target 35096064 hsa-mir-23a Colonic Neoplasms These findings indicate that miR-323a-3p regulates the proliferation, migration, invasion, and apoptosis of COAD cells by targeting NEK6. +exosome 35096062 hsa-mir-4792 Urinary Bladder Neoplasms Exosome-Mediated miR-4792 Transfer Promotes Bladder Cancer Cell Proliferation via Enhanced FOXC1/c-Myc Signaling and Warburg Effect. +lncRNA target 35096015 hsa-mir-654 Paranasal Sinus Neoplasms 3p as an antitumor gene targeted CREB1 to hamper malignant progression of SNSCC through miR +other 35095999 hsa-mir-143 Adenocarcinoma of Lung PCAT19/miR3p plays a very important regulatory role in the occurrence and development of LUAD. +other 35095996 hsa-mir-93 Prostatic Neoplasms Here we report the relevant role of IGF2 and miR5p as non-invasive biomarker for PC. +lncRNA target 35095879 hsa-mir-30 Ovarian Neoplasms Additionally, according to public data, the LRRC75A-AS1-hsa-miR5p axis could inhibit the immune response of OC patients by upregulating CDK4/6, leading to a poor prognosis. +other 35095769 hsa-mir-1225 Adenocarcinoma of Lung Finally, we constructed a ceRNA network that included two microRNAs (hsa-miR5p, hsa-miR-575) and five mRNAs (BARX2, BCL9, KCNK1, KIAA1324, TMEM182) specific to LINC00467 in LUAD. +other 35095769 hsa-mir-575 Adenocarcinoma of Lung Finally, we constructed a ceRNA network that included two microRNAs (hsa-miR5p, hsa-miR-575) and five mRNAs (BARX2, BCL9, KCNK1, KIAA1324, TMEM182) specific to LINC00467 in LUAD. +other 35095494 hsa-mir-92a Uterine Cervical Neoplasms MicroRNA-92a-3p Enhances Cisplatin Resistance by Regulating Krüppel-Like Factor 4-Mediated Cell Apoptosis and Epithelial-to-Mesenchymal Transition in Cervical Cancer. +other 35094988 hsa-mir-650 Carcinoma, Hepatocellular RESULTS: MiR-676 and miR-650 were powerful in discriminating cirrhotic and late fibrosis from HCC. MiR-650 could distinguish mild (f0-f1) and advanced (f2-f3) fibrosis from HCC cases. +other 35094988 hsa-mir-512 Hcv Associated Disorders 5p were positively correlated in the cirrhotic group and in (f0-f4) group. +other 35094988 hsa-mir-512 Hepatitis C 5p were positively correlated in the cirrhotic group and in (f0-f4) group. +other 35094988 hsa-mir-512 Carcinoma, Hepatocellular 5p were positively correlated in the cirrhotic group and in (f0-f4) group. +other 35094988 hsa-mir-650 Hepatitis C RESULTS: MiR-676 and miR-650 were powerful in discriminating cirrhotic and late fibrosis from HCC. MiR-650 could distinguish mild (f0-f1) and advanced (f2-f3) fibrosis from HCC cases. +other 35094988 hsa-mir-650 Hcv Associated Disorders RESULTS: MiR-676 and miR-650 were powerful in discriminating cirrhotic and late fibrosis from HCC. MiR-650 could distinguish mild (f0-f1) and advanced (f2-f3) fibrosis from HCC cases. +circulation_biomarker_diagnosis_up 35094987 hsa-mir-370 Leukemia, Myeloid, Acute CONCLUSION: miR-370 level in peripheral blood can serve as a potential non-invasive diagnostic biomarker and was significantly correlated with AML risk. +lncRNA target 35094653 hsa-mir-423 Breast Neoplasms As a result, our work illustrated the tumor suppressor role of MBNL1-AS1 in breast cancer via upregulating miR +lncRNA target 35094651 hsa-mir-145 Substance Abuse, Intravenous This study confirms that NR2F1-AS1 modulates IVDD progression by up-regulating the FOXO1 pathway through the sponge of miR +transcription factor target 35094634 hsa-mir-26 Stomach Neoplasms Therefore, PFKFB3 down-regulated by miR5p inhibited the malignant phenotype of GC with hyperglycemia. +transcription factor target 35094593 hsa-mir-21 Precancerous Conditions Presumptively, RUc may inhibit the angiogenesis of breast precancerous lesions by inhibiting Ras/Raf/MEK/ERK signaling pathway, thus relieving the inhibition of miR-21 on TIMP-3 and RECK, then down-regulating the secretion of angiogenic factors. +genetics_knock down_promote 35094303 hsa-mir-135b Nasopharyngeal Carcinoma Notably, knockdown of SIRT1 partially reversed the miR-135b-5p-induced change of EMT markers and metastasis of NPC cells. +genetics_knock down_promote 35094292 hsa-mir-103a Uterine Cervical Neoplasms Moreover, FBXW7 knockdown efficiently abrogated the influences of CC cells proliferation caused by miR-103a-3p inhibition. +lncRNA target 35094286 hsa-mir-124 Endometriosis CONCLUSIONS: NEAT1 is significantly upregulated in EM, promoting malignant behavior in EM through targeting miR +genetics_overexpression_suppress 35094251 hsa-mir-25 Pancreatitis Characteristic western blot, immunohistochemistry, and transmission electron microscopy results revealed that overexpression of miR +genetics_overexpression_promote 35093879 hsa-mir-378 Carcinoma, Renal Cell Second, overexpression of miR-378 significantly suppressed the expression of POLR2A and RUNX2 in sRCC cells (p<0.01) and enhanced apoptosis (p<0.05). +transcription factor target 35093804 hsa-mir-190a Liver Cirrhosis Our study aims to investigate whether resveratrol (Res) can alleviate liver fibrosis through miR-190a-5p /HGF axis. +exosome 35093789 hsa-mir-342 Breast Neoplasms Extracellular vesicles extracted from bone marrow mesenchymal stem cells carrying MicroRNA-342-3p inhibit the INHBA/IL13Rα2 axis to suppress the growth and metastasis of breast cancer. +lncRNA target 35093695 hsa-mir-34c Squamous Cell Carcinoma of Head and Neck CONCLUSION: Our findings revealed a novel strategy to upregulate erastin-induced ferroptosis in OSCC through the miR-34c-3p/SLC7A11 axis, suggesting new insights into OSCC and a potentially useful therapeutic strategy for OSCC. +other 35093630 hsa-mir-107 Nervous System Diseases OBJECTIVES: The aberrant expression of miR-107 has been confirmed in some neurological diseases, including ischemic stroke (IS). +other 35093630 hsa-mir-107 Infarction, Middle Cerebral Artery RESULTS: Bioinformatics analysis revealed that miR-107 expression was elevated in rats with middle cerebral artery occlusion (MCAO), which was confirmed in OGD/R-treated PC12 cells. +other 35093630 hsa-mir-107 Ischemic Stroke OBJECTIVES: The aberrant expression of miR-107 has been confirmed in some neurological diseases, including ischemic stroke (IS). RESULTS: Bioinformatics analysis revealed that miR-107 expression was elevated in rats with middle cerebral artery occlusion (MCAO), which was confirmed in OGD/R-treated PC12 cells. +genetics_knock down_promote 35093599 hsa-mir-578 Carcinoma, Hepatocellular CONCLUSIONS: Circ-LARP1B knockdown restrained HCC tumorigenicity and enhanced radiosensitivity by regulating miR-578/IGF1R axis, providing a new target for the treatment of HCC. +genetics_overexpression_promote 35093591 hsa-mir-24-1 Liver Cirrhosis CONCLUSIONS: Hepatic overexpression of the miR-23b/27b/24-1 cluster blocked hepatic fibrosis and may be a novel therapeutic regimen for patients with hepatic fibrosis. +genetics_overexpression_promote 35093591 hsa-mir-27b Liver Cirrhosis CONCLUSIONS: Hepatic overexpression of the miR-23b/27b/24-1 cluster blocked hepatic fibrosis and may be a novel therapeutic regimen for patients with hepatic fibrosis. +genetics_overexpression_promote 35093591 hsa-mir-23b Liver Cirrhosis CONCLUSIONS: Hepatic overexpression of the miR-23b/27b/24-1 cluster blocked hepatic fibrosis and may be a novel therapeutic regimen for patients with hepatic fibrosis. +genetics_overexpression_promote 35093109 hsa-mir-671 Arthritis, Rheumatoid 5p overexpression restrained RA-FLS growth, invasion, migration and inflammation and promoted apoptosis, but STAT3 upregulation reversed the impacts. +genetics_knock down_promote 35092863 hsa-mir-3680 Osteoarthritis Moreover, our in vivo study found that after knockdown of miR +transcription factor target 35092734 hsa-mir-376c Reperfusion Injury, Renal Ischemia Consequently, miR-376c-3p played an important role in renal IRI by promoting angiogenesis via targeting HIF-1alpha/VEGF pathway in male rats. +epigenetics 35092653 hsa-mir-4442 Developmental Disabilities The top 3 miRNA genes, promoters of which were the most statistically significantly hypermethylated in BCP ALL were MIR1273G, MIR1304 and MIR663, and the top 3 hypomethylated were MIR4442, MIR155 and MIR3909. +epigenetics 35092653 hsa-mir-155 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma The top 3 miRNA genes, promoters of which were the most statistically significantly hypermethylated in BCP ALL were MIR1273G, MIR1304 and MIR663, and the top 3 hypomethylated were MIR4442, MIR155 and MIR3909. +epigenetics 35092653 hsa-mir-1273g Developmental Disabilities The top 3 miRNA genes, promoters of which were the most statistically significantly hypermethylated in BCP ALL were MIR1273G, MIR1304 and MIR663, and the top 3 hypomethylated were MIR4442, MIR155 and MIR3909. +epigenetics 35092653 hsa-mir-663 Developmental Disabilities The top 3 miRNA genes, promoters of which were the most statistically significantly hypermethylated in BCP ALL were MIR1273G, MIR1304 and MIR663, and the top 3 hypomethylated were MIR4442, MIR155 and MIR3909. +epigenetics 35092653 hsa-mir-1273g Precursor B-Cell Lymphoblastic Leukemia-Lymphoma The top 3 miRNA genes, promoters of which were the most statistically significantly hypermethylated in BCP ALL were MIR1273G, MIR1304 and MIR663, and the top 3 hypomethylated were MIR4442, MIR155 and MIR3909. +epigenetics 35092653 hsa-mir-1304 Developmental Disabilities The top 3 miRNA genes, promoters of which were the most statistically significantly hypermethylated in BCP ALL were MIR1273G, MIR1304 and MIR663, and the top 3 hypomethylated were MIR4442, MIR155 and MIR3909. +epigenetics 35092653 hsa-mir-4442 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma The top 3 miRNA genes, promoters of which were the most statistically significantly hypermethylated in BCP ALL were MIR1273G, MIR1304 and MIR663, and the top 3 hypomethylated were MIR4442, MIR155 and MIR3909. +epigenetics 35092653 hsa-mir-1304 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma The top 3 miRNA genes, promoters of which were the most statistically significantly hypermethylated in BCP ALL were MIR1273G, MIR1304 and MIR663, and the top 3 hypomethylated were MIR4442, MIR155 and MIR3909. +epigenetics 35092653 hsa-mir-3909 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma The top 3 miRNA genes, promoters of which were the most statistically significantly hypermethylated in BCP ALL were MIR1273G, MIR1304 and MIR663, and the top 3 hypomethylated were MIR4442, MIR155 and MIR3909. +epigenetics 35092653 hsa-mir-3909 Developmental Disabilities The top 3 miRNA genes, promoters of which were the most statistically significantly hypermethylated in BCP ALL were MIR1273G, MIR1304 and MIR663, and the top 3 hypomethylated were MIR4442, MIR155 and MIR3909. +epigenetics 35092653 hsa-mir-663 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma The top 3 miRNA genes, promoters of which were the most statistically significantly hypermethylated in BCP ALL were MIR1273G, MIR1304 and MIR663, and the top 3 hypomethylated were MIR4442, MIR155 and MIR3909. +epigenetics 35092653 hsa-mir-155 Developmental Disabilities The top 3 miRNA genes, promoters of which were the most statistically significantly hypermethylated in BCP ALL were MIR1273G, MIR1304 and MIR663, and the top 3 hypomethylated were MIR4442, MIR155 and MIR3909. +circulation_biomarker_diagnosis_up 35092573 hsa-mir-18b Polycystic Ovary Syndrome Based on that, circulating miR-18b-5p levels can contribute to the progression of PCOS complications. +lncRNA target 35092560 hsa-mir-206 Myocardial Infarction Therefore, targeting the HOTAIR/miR-206/FN1 axis may be a promising therapeutic method for MI. +other 35091894 hsa-mir-148a Enterocolitis, Necrotizing Collectively, our present study demonstrated that the miR-148a-3p/p53/SIRT1 axis has a considerable protective effect on NEC, and the agomir therapy provides a new treatment strategy for NEC. +genetics_overexpression_promote 35091706 hsa-mir-146b Hirschsprung Disease CONCLUSION: Circ-ITCH overexpression facilitated cell proliferation and migration in HSCR by regulating miR-146b-5p/RET/MAPK axis. +other 35091542 hsa-mir-146a Leukemia, Myelogenous, Chronic, BCR-ABL Positive A mechanism study indicated that USP6 regulation of IM resistance of CML cells was GLS1 dependent and regulated by miR-146a-5p. +lncRNA target 35091542 hsa-mir-146a Leukemia Dysregulation of miR-146a has been found in both adult and pediatric patients with acute leukemia. +genetics_overexpression_promote 35091535 hsa-mir-432 Cholangiocarcinoma In contrast, overexpression of transcription factor E2F3 in CCA cells restored the CCA cellular activities that were inhibited by miR +lncRNA target 35091534 hsa-mir-124 Sepsis 3p improves myocardial injury in septic rats through targeted regulation of SP1 to mediate HDAC4/HIF-1alpha. +lncRNA target 35091534 hsa-mir-124 Cardiomyopathies 3p improves myocardial injury in septic rats through targeted regulation of SP1 to mediate HDAC4/HIF-1alpha. +genetics_overexpression_promote 35091088 hsa-mir-30 Colorectal Neoplasms 3p inhibitor or MYO6 overexpression attenuated the repressive impacts of circ_0011385 silencing on CRC process. +lncRNA target 35090549 hsa-mir-588 Diabetic Nephropathies CONCLUSIONS: Altogether, our data suggest that ZFAS1 regulates the proliferation, oxidative stress, fibrosis, and inflammation of high glucose-induced diabetic nephropathy through the miR-588/ROCK1 axis. +lncRNA target 35090549 hsa-mir-588 Inflammation CONCLUSIONS: Altogether, our data suggest that ZFAS1 regulates the proliferation, oxidative stress, fibrosis, and inflammation of high glucose-induced diabetic nephropathy through the miR-588/ROCK1 axis. +lncRNA target 35090460 hsa-mir-199b Colorectal Neoplasms CONCLUSIONS: Our findings suggest miR-199b-3p might serve as a promising therapeutic target against CTx resistant CRC, and provide scientific information for exploring novel strategies of improving the efficacy of CTx for CRC patients. +other 35090416 hsa-mir-4443 Adenocarcinoma of Lung ENST00000630242 ceRNA network was identified in LUAD. +transcription factor target 35090386 hsa-mir-1 Intestinal Diseases 3p, and then blocking the Smad pathway to alleviate intestinal epithelial inflammation and oxidative stress injury caused by sepsis. +transcription factor target 35090386 hsa-mir-1 Sepsis 3p, and then blocking the Smad pathway to alleviate intestinal epithelial inflammation and oxidative stress injury caused by sepsis. +lncRNA target 35090377 hsa-mir-33a Uterine Cervical Neoplasms TP53TG1 accelerates the CC development via regulating miR-33a-5p to target FOXK2 with the involvement of PI3K/AKT/mTOR signaling pathway. +other 35090094 hsa-mir-218 Parkinson Disease 3p/GTF2H3, as well as multiple proteins, such as CHI3L1, HSPA1B, FNIP2 and TH. +other 35090094 hsa-mir-369 Parkinson Disease 3p/GTF2H3, as well as multiple proteins, such as CHI3L1, HSPA1B, FNIP2 and TH. +other 35090094 hsa-mir-539 Parkinson Disease 3p/GTF2H3, as well as multiple proteins, such as CHI3L1, HSPA1B, FNIP2 and TH. +lncRNA target 35089659 hsa-mir-4516 Carcinoma, Hepatocellular In addition, the inhibition of miR-4516 partly reversed the inhibitory effect of LINC00520 silencing on HCC cell proliferation, migration and invasion. In conclusion, the inhibition of LINC00520 suppressed HCC cell proliferation, migration and invasion through mediating miR-4516/SOX5 axis. +genetics_overexpression_promote 35089495 hsa-mir-24 Cardiotoxicity Overexpression of miR +lncRNA target 35089454 hsa-mir-433 Carcinoma, Non-Small-Cell Lung CircZCCHC6 inhibited the progression of NSCLC cells partly by regulating the miR3p/LPCAT1 axis, implying a promising therapeutic target for the NSCLC treatment. +genetics_overexpression_suppress 35089329 hsa-mir-223 Fusarium Solani-Induced Keratitis 3p attenuated inflammation in FK, reduced P62 expression, and increased the ratio of LC3-II/LC3-I, whereas the overexpression of miR +lncRNA target 35088877 hsa-mir-432 Colorectal Neoplasms Thus, the LINC00649/miR4325p/HDGF pathway may be a promising target for CRC therapy. +lncRNA target 35088561 hsa-mir-195 Diabetes Mellitus, Type 2 OBJECTIVE: The aim of this study was to research the role and underlying mechanism of miR-195 involved in pancreatic beta-cell dedifferentiation induced by hyperlipemia in type 2 diabetes mellitus. CONCLUSIONS: MiR-195 promoted beta-cell dedifferentiation through negatively regulating Mfn2 expression and inhibiting the IRS-1/2/Pi3k/Akt pathway, providing a promising treatment for type 2 diabetes mellitus. +circulation_biomarker_diagnosis_ns 35088558 hsa-mir-2 Diabetes Mellitus, Type 2 5p) and four clinical variables (T2D medication, sex, age, and fasting blood glucose). +circulation_biomarker_diagnosis_ns 35088558 hsa-mir-1 Diabetes Mellitus, Type 2 5p) and four clinical variables (T2D medication, sex, age, and fasting blood glucose). +circulation_biomarker_diagnosis_ns 35088558 hsa-mir-21 Diabetes Mellitus, Type 2 5p) and four clinical variables (T2D medication, sex, age, and fasting blood glucose). +other 35088373 hsa-mir-7 Brain Diseases Thus, we show that miR-7 is an essential miRNA in the brain that prevents alpha-Syn translation and the ensuing brain damage after stroke. +other 35088373 hsa-mir-7a Stroke We previously showed that treatment with miR-7 mimic prevents alpha-Syn induction and protects brain after stroke in rodents irrespective of age and sex. Thus, we show that miR-7 is an essential miRNA in the brain that prevents alpha-Syn translation and the ensuing brain damage after stroke. +other 35088373 hsa-mir-7 Stroke We previously showed that treatment with miR-7 mimic prevents alpha-Syn induction and protects brain after stroke in rodents irrespective of age and sex. Thus, we show that miR-7 is an essential miRNA in the brain that prevents alpha-Syn translation and the ensuing brain damage after stroke. +other 35088373 hsa-mir-7a Brain Diseases Thus, we show that miR-7 is an essential miRNA in the brain that prevents alpha-Syn translation and the ensuing brain damage after stroke. +genetics_overexpression_promote 35088289 hsa-mir-455 Osteochondritis Dissecans miR-455 overexpression also promoted SH-SY5Y cell viability and rescued them from OGD/R-induced apoptosis by binding to GPER1. +circulation_biomarker_diagnosis_up 35088229 hsa-mir-128 Constriction, Pathologic 3p was negatively associated with blood lipid level (LDL-C), inflammatory cytokines (TNF-alpha, IL-1beta, IL-6), cell adhesion molecules (VCAM-1, ICAM-1), and Gensini score (all P < 0.05) in CHD patients. +circulation_biomarker_diagnosis_up 35088229 hsa-mir-128 Coronary Disease 3p was negatively associated with blood lipid level (LDL-C), inflammatory cytokines (TNF-alpha, IL-1beta, IL-6), cell adhesion molecules (VCAM-1, ICAM-1), and Gensini score (all P < 0.05) in CHD patients. +lncRNA target 35088224 hsa-mir-153 Stomach Neoplasms 3p suppressed the growth and metastasis in GC cells by regulating SphK2, which might facilitate the search for novel biomarkers to treat GC. +exosome 35088190 hsa-mir-514a Stomach Neoplasms Linc00852 from cisplatin-resistant gastric cancer cell-derived exosomes regulates COMMD7 to promote cisplatin resistance of recipient cells through microRNA-514a-5p. +lncRNA target 35087989 hsa-mir-34a Parkinson Disease We therefore suggest that 7-BIO inhibition of GSK3beta alleviates the MPP(+) induced neurotoxicity by regulating miR-29a-3p and miR-34a-5p expressions in Parkinson's disease model SH-SY5Y cells. +lncRNA target 35087989 hsa-mir-29a Parkinson Disease We therefore suggest that 7-BIO inhibition of GSK3beta alleviates the MPP(+) induced neurotoxicity by regulating miR-29a-3p and miR-34a-5p expressions in Parkinson's disease model SH-SY5Y cells. +lncRNA target 35087744 hsa-mir-195 Leukoplakia, Oral Hsa_circ_0060927 was expected to be a molecular marker for the prevention and treatment of OLK carcinogenesis through the hsa_circ_0060927/miR +lncRNA target 35087744 hsa-mir-195 Squamous Cell Carcinoma of Head and Neck Hsa_circ_0060927 was expected to be a molecular marker for the prevention and treatment of OLK carcinogenesis through the hsa_circ_0060927/miR +target gene 35087570 hsa-mir-557 Osteosarcoma Hsa-miR-557 Inhibits Osteosarcoma Growth Through Targeting KRAS. +other 35087281 hsa-mir-195 Diabetes Mellitus, Type 2 Moreover, the rs78312845 in miR-195 contributed to the level of FPG and HbA1C in nondiabetic group in the Han Chinese population. +genetics_GWAS 35087281 hsa-mir-144 Diabetes Mellitus, Type 2 METHODS: The aim of this study was to investigate the association of T2DM with 12 single nucleotide polymorphisms (SNPs) in 7 miRNAs (miR-195, miR-126, miR-144, miR-155, miR-21, miR-93 and miR-222) involved in the insulin resistance pathway. +genetics_GWAS 35087281 hsa-mir-155 Diabetes Mellitus, Type 2 METHODS: The aim of this study was to investigate the association of T2DM with 12 single nucleotide polymorphisms (SNPs) in 7 miRNAs (miR-195, miR-126, miR-144, miR-155, miR-21, miR-93 and miR-222) involved in the insulin resistance pathway. +genetics_GWAS 35087281 hsa-mir-222 Diabetes Mellitus, Type 2 METHODS: The aim of this study was to investigate the association of T2DM with 12 single nucleotide polymorphisms (SNPs) in 7 miRNAs (miR-195, miR-126, miR-144, miR-155, miR-21, miR-93 and miR-222) involved in the insulin resistance pathway. +genetics_GWAS 35087281 hsa-mir-93 Diabetes Mellitus, Type 2 METHODS: The aim of this study was to investigate the association of T2DM with 12 single nucleotide polymorphisms (SNPs) in 7 miRNAs (miR-195, miR-126, miR-144, miR-155, miR-21, miR-93 and miR-222) involved in the insulin resistance pathway. +genetics_GWAS 35087281 hsa-mir-126 Diabetes Mellitus, Type 2 METHODS: The aim of this study was to investigate the association of T2DM with 12 single nucleotide polymorphisms (SNPs) in 7 miRNAs (miR-195, miR-126, miR-144, miR-155, miR-21, miR-93 and miR-222) involved in the insulin resistance pathway. +lncRNA target 35087196 hsa-mir-20b Alzheimer Disease Network analysis of protein-protein interactions and gene coexpression revealed other important potential miR-20b-5p targets among AD-related proteins/genes. +genetics_knock down_suppress 35086110 hsa-mir-133b Carcinoma, Renal Cell Importantly, miR-133b inhibition or MARCKS knockdown attenuated the anticancer effects of circ_0039569 knockdown on RCC growth. CONCLUSION: Diminished circ_0039569 restrains the growth and propagation of RCC cells via miR-133b/MARCKS axis, indicating an underlying effective therapeutic target for RCC patients. +lncRNA target 35085910 hsa-mir-520h Polycystic Ovary Syndrome Collectively, miR-520h hindered the proliferation and promoted the apoptosis of KGN cells via targeting IL6R to inhibit the development of PCOS, and these effects were possibly realized by JAK/STAT pathway. +lncRNA target 35085892 hsa-mir-4746 Colorectal Neoplasms As revealed by function and mechanism experiments, targeting CCND1 mRNA 3'-UTR, mir-4746 can promote the degradation of CCND1 mRNA, thus reducing the protein level of CCND1, leading to cell G0-G1 phase arrest, and ultimately inhibiting the proliferation of CRC cells. +transcription factor target 35085590 hsa-mir-34a Thyroid Cancer, Papillary Results showed that crocin inhibited the viability and miR-34a-5p expression in papillary thyroid cancer (PTC) cells in a dose-dependent manner. +transcription factor target 35085578 hsa-mir-19b Osteoporosis The results show that miRNA-19b-3p plays an important role in the osteoporosis process after SCI through regulating EBF2 expression. +transcription factor target 35085578 hsa-mir-19b Spinal Cord Injuries The results show that miRNA-19b-3p plays an important role in the osteoporosis process after SCI through regulating EBF2 expression. +lncRNA target 35084673 hsa-mir-183 Thyroid Neoplasms FOXO1 silencing reversed the inhibitory effect of miR +genetics_overexpression_promote 35084661 hsa-mir-192 Hypoxia-Ischemia, Brain 5p or overexpressed YAP1 in HIBD rats alleviated neurobehavioral impairment and neuronal damage, and decreased the expression levels of p-TAZ and VEGF expression in vivo. +lncRNA target 35084640 hsa-mir-206 Diabetic Nephropathies The current study analyzes the role played by NEAT2/miR-206 upon cell death of renal tubular epithelial cells (RTECs), high glucose (HG)-induced inflammation and oxidative stress in diabetic nephropathy (DN). This miR-206 is predicted to be a latent target in the clinical treatment of DN. +exosome 35084622 hsa-mir-660 Breast Neoplasms Interestingly, EV-loaded miR-660 from TAMs could be internalized by breast cancer cells. +other 35084609 hsa-mir-136 Myocardial Infarction This study investigated how miR5p partially affected cardiomyocyte pyroptosis in rats with coronary microembolization (CME). +genetics_overexpression_promote 35084609 hsa-mir-136 Costello Syndrome 5p was under-expressed, whereas ATXN1L was overexpressed in rats with CME and in LPS-treated primary cardiomyocytes. +transcription factor target 35084609 hsa-mir-136 Heart Diseases In conclusion, miR5p suppressed pyroptosis by upregulating PYDC1 via ATXN1L/CIC axis, thereby attenuating cardiac damage caused by CME. +circRNA target 35084579 hsa-mir-532 Angelman Syndrome CONCLUSION: To sum up, our data showed that circCHMP5 regulated the miR5p/ROCK2 axis to accelerate ox-LDL-induced HUVECs injury, confirming that circCHMP5 might be a potential target for AS treatment. +other 35084460 hsa-mir-205 Diabetic Nephropathies Here, we describe a novel feedback loop composed of HDAC2 and miR-205 that regulates ECM production in tubular epithelial cells in individuals with DKD. In conclusion, the HDAC2/SP1/miR-205 feedback loop may be crucial for the pathogenesis of DKD. +other 35084431 hsa-mir-299 Retinopathy of Prematurity We used this model and human retinal endothelial cells (HRECs) under hypoxia to explore the relationship between taurine upregulated gene-1 (TUG1), vascular endothelial growth factor (VEGF), and miR3p on retinopathy of prematurity (ROP). +lncRNA target 35084431 hsa-mir-299 Retinal Neovascularization CONCLUSIONS: TUG1 reduces the expression of VEGFA by competitively adsorbing miR3p and facilitates the regulation of retinal neovascularization, suggesting that it may serve as a new therapeutic target for retinal neovascular diseases. +transcription factor target 35084199 hsa-mir-146a Colitis In conclusion, our findings showed that hucMSC-Ex is effective in alleviating the deterioration of colitis via the miR-146a-mediated inhibition of SUMO1, which is crucial in this disease process. +genetics_knock down_promote 35083866 hsa-mir-493 Esophageal Neoplasms Moreover, circFIG 4 knockdown inhibited EC tumorigenesis by targeting miR +transcription factor target 35083664 hsa-mir-876 Glioma 5p-targeted GNG12 contributes to the malignant development of glioma by increasing the PI3K/AKT signaling activity. +other 35083632 hsa-mir-92b Polycystic Ovary Syndrome We observed that circ-PRDM5 and COL1A2 were upregulated in PCO tissues and TGF-beta2-treated LECs, while miR-92b-3p was downregulated. In summary, TGF-beta2-induced circ-PRDM5 facilitated LEC migration, invasion, and EMT by adsorbing miR-92b-3p and increasing COL1A2 expression, offering new insights into the development of PCO. +transcription factor target 35083625 hsa-mir-26a Inflammation Collectively, these results suggest that miR-26a may function as a novel feedback negative regulator of the hyperinflammatory response and as a drug target for the progression of inflammation. +lncRNA target 35083615 hsa-let-7a Pulmonary Fibrosis 5p contribute a pivotal role in pulmonary fibrosis and may be considered as possible therapeutic target for the clinical management of lung fibrosis. +lncRNA target 35083615 hsa-mir-503 Pulmonary Fibrosis 5p contribute a pivotal role in pulmonary fibrosis and may be considered as possible therapeutic target for the clinical management of lung fibrosis. +circulation_biomarker_diagnosis_up 35083607 hsa-mir-146b Abortion, Habitual Statistical analysis indicated miR-146b-5p expression was significantly up-regulated in URSA patients compared to normal pregnant women (P = 0.018). The circulating levels of miR-520 h and miR-146b-5p could be considered biomarkers for URSA diagnosis. +genetics_overexpression_promote 35083555 hsa-mir-22 Arthritis, Rheumatoid 3p or overexpression of CYR61 annulled the inhibitory effect of EZH2 silencing on RA-FLS proliferation, migration, and invasion. +other 35083300 hsa-mir-190a Arrhythmias, Cardiac This study aimed to investigate the molecular mechanism underlying the regulation of IL-2 and the sodium channel current of sodium voltage-gated channel beta subunit 3 (SCN3B) by miR-190a-5p in the progression of CAs. We, therefore, concluded that the miR-190a-5p/IL-2/SCN3B pathway could be involved in the pathogenesis of CAs and miR-190a-5p might acts as a potential protective factor in pathogenesis of CAs. +exosome 35083214 hsa-mir-140 Iris Diseases SW-exo exerted a stronger therapeutic effect on H/R injury in H9c2 cells possibly via delivering exosomal miR3p, which might be a novel promising strategy for the myocardial IRI. +exosome 35083214 hsa-mir-140 Myocardial Ischemia SW-exo exerted a stronger therapeutic effect on H/R injury in H9c2 cells possibly via delivering exosomal miR3p, which might be a novel promising strategy for the myocardial IRI. +transcription factor target 35083181 hsa-mir-766 Colonic Neoplasms 3p/TGFBI axis suppressed malignant behaviors and facilitated apoptosis of colon cancer cells. +other 35083143 hsa-mir-361 Uterine Cervical Neoplasms SOX9, lncRNA ANXA2P2, and miR-361-3p form a regulatory loop, modulating DDP-resistant cervical cancer cell growth and response to DDP treatment. +transcription factor target 35083134 hsa-mir-136 Glioma Hereby, we aim to explore the role of LINC00883 as a regulator of miR-136 and its target, NIMA-related kinase 1 (NEK1), thus, its involvement in the drug resistance of glioma cells. +other 35083026 hsa-mir-641 Breast Neoplasms Moreover, miR-641 was negatively correlated with NR2F1-AS1 in BC tissues. +circulation_biomarker_diagnosis_ns 35083018 hsa-mir-223 Pancreatitis, Chronic OBJECTIVES: This study aimed to research the roles of miR-139, miR-221, miR-200c, miR-145, miR-223, miR-424, and miR-377 in endoplasmic reticulum stress (ERS), oxidative stress (OS), fibrosis, and apoptosis processes in chronic pancreatitis (CP) rat model. +circulation_biomarker_diagnosis_ns 35083018 hsa-mir-221 Pancreatitis, Chronic OBJECTIVES: This study aimed to research the roles of miR-139, miR-221, miR-200c, miR-145, miR-223, miR-424, and miR-377 in endoplasmic reticulum stress (ERS), oxidative stress (OS), fibrosis, and apoptosis processes in chronic pancreatitis (CP) rat model. +circulation_biomarker_diagnosis_ns 35083018 hsa-mir-139 Pancreatitis, Chronic OBJECTIVES: This study aimed to research the roles of miR-139, miR-221, miR-200c, miR-145, miR-223, miR-424, and miR-377 in endoplasmic reticulum stress (ERS), oxidative stress (OS), fibrosis, and apoptosis processes in chronic pancreatitis (CP) rat model. +circulation_biomarker_diagnosis_ns 35083018 hsa-mir-377 Pancreatitis, Chronic OBJECTIVES: This study aimed to research the roles of miR-139, miR-221, miR-200c, miR-145, miR-223, miR-424, and miR-377 in endoplasmic reticulum stress (ERS), oxidative stress (OS), fibrosis, and apoptosis processes in chronic pancreatitis (CP) rat model. +circulation_biomarker_diagnosis_ns 35083018 hsa-mir-200c Pancreatitis, Chronic OBJECTIVES: This study aimed to research the roles of miR-139, miR-221, miR-200c, miR-145, miR-223, miR-424, and miR-377 in endoplasmic reticulum stress (ERS), oxidative stress (OS), fibrosis, and apoptosis processes in chronic pancreatitis (CP) rat model. +circulation_biomarker_diagnosis_ns 35083018 hsa-mir-145 Pancreatitis, Chronic OBJECTIVES: This study aimed to research the roles of miR-139, miR-221, miR-200c, miR-145, miR-223, miR-424, and miR-377 in endoplasmic reticulum stress (ERS), oxidative stress (OS), fibrosis, and apoptosis processes in chronic pancreatitis (CP) rat model. +circulation_biomarker_diagnosis_ns 35083018 hsa-mir-424 Pancreatitis, Chronic OBJECTIVES: This study aimed to research the roles of miR-139, miR-221, miR-200c, miR-145, miR-223, miR-424, and miR-377 in endoplasmic reticulum stress (ERS), oxidative stress (OS), fibrosis, and apoptosis processes in chronic pancreatitis (CP) rat model. +lncRNA target 35083006 hsa-mir-21 Breast Neoplasms CONCLUSION: It appears that aerobic exercise training reduces tumor size and ameliorates breast cancer by reducing miR-21 gene expression, suppressing the apoptosis process, and reducing angiogenesis. +genetics_overexpression_suppress 35082967 hsa-mir-126 Coronary Artery Disease Overexpression of miR-126 significantly improved HUVEC cellular viabilities by downregulation of LRP6 protein expression, suggesting a potential therapeutic target for CAD patients. +other 35082915 hsa-mir-128 Asthma CONCLUSION: lncRNA-NEAT1 sponges miR-128 to boost PDGF-BB-induced inflammatory reaction and phenotypic transformation of ASMCs to aggravate the occurrence and development of childhood bronchial asthma. +genetics_overexpression_promote 35082911 hsa-mir-335 Leiomyoma Furthermore, overexpression of ARGLU1 partly restores the effects of miR +lncRNA target 35082831 hsa-mir-1343 Stomach Neoplasms 3p could be introduced as a valuable target for studies on the GC diagnosis using reliable biomarkers. +lncRNA target 35082786 hsa-mir-23 Acute Coronary Syndrome 5p inhibitor greatly promoted levels of PPP-related genes, reduced the macrophage phagocytosis of ACs, and increased inflammatory response during efferocytosis, suggesting that miR +other 35082517 hsa-mir-4636 Colorectal Neoplasms RESULTS: Six clinicopathologic factors and expressions of six microRNAs (miR-614, miR-1197, miR-4770, miR-3136, miR-3173, and miR-4636) differed significantly between TDs and non-TDs CRC patients from the SEER and TCGA training sets. +other 35082517 hsa-mir-4770 Colorectal Neoplasms RESULTS: Six clinicopathologic factors and expressions of six microRNAs (miR-614, miR-1197, miR-4770, miR-3136, miR-3173, and miR-4636) differed significantly between TDs and non-TDs CRC patients from the SEER and TCGA training sets. +other 35082509 hsa-mir-196a Carcinoma, Squamous Cell, Cutaneous More importantly, miR-196a was shown to have potential as a prognostic marker for CSCC. +genetics_knock down_promote 35082399 hsa-mir-28 Lymphoma, Large B-Cell, Diffuse 5p inhibition could reverse the effect of CDK12 knockdown on proliferation and apoptosis of DLBCL cells. +other 35082354 hsa-mir-145 Immune System Diseases Next, we explored the effects of interventions with the trypanosomicidal drug Benznidazole (Bz) alone or combined with Pentoxifylline (PTX), a methylxanthine derivative shown to modulate immunological and cardiac abnormalities in a model of chronic chagasic cardiomyopathy, on parasite load and expression of miR5p and miR-146b-5p. +other 35082354 hsa-mir-145 Chagas Disease Thus, miR5p and miR-146b-5p deserve to be further investigated as biomarkers of parasite control and tools to identify therapeutic adjuvants to etiological treatment in Chagas disease. +other 35082354 hsa-mir-145 Chagas Cardiomyopathy Next, we explored the effects of interventions with the trypanosomicidal drug Benznidazole (Bz) alone or combined with Pentoxifylline (PTX), a methylxanthine derivative shown to modulate immunological and cardiac abnormalities in a model of chronic chagasic cardiomyopathy, on parasite load and expression of miR5p and miR-146b-5p. +other 35082354 hsa-mir-146b Chagas Cardiomyopathy Next, we explored the effects of interventions with the trypanosomicidal drug Benznidazole (Bz) alone or combined with Pentoxifylline (PTX), a methylxanthine derivative shown to modulate immunological and cardiac abnormalities in a model of chronic chagasic cardiomyopathy, on parasite load and expression of miR5p and miR-146b-5p. +other 35082354 hsa-mir-146b Chagas Disease Thus, miR5p and miR-146b-5p deserve to be further investigated as biomarkers of parasite control and tools to identify therapeutic adjuvants to etiological treatment in Chagas disease. +other 35082354 hsa-mir-146b Immune System Diseases Next, we explored the effects of interventions with the trypanosomicidal drug Benznidazole (Bz) alone or combined with Pentoxifylline (PTX), a methylxanthine derivative shown to modulate immunological and cardiac abnormalities in a model of chronic chagasic cardiomyopathy, on parasite load and expression of miR5p and miR-146b-5p. +circulation_biomarker_diagnosis_ns 35082326 hsa-let-7f Amyotrophic Lateral Sclerosis Receiver operating characteristic (ROC) analysis also highlighted the let-7f-5p and miR3p potential as robustness plasma biomarkers for diagnosis and potential therapeutic targets of sALS disease. +circulation_biomarker_diagnosis_ns 35082326 hsa-mir-338 Amyotrophic Lateral Sclerosis Receiver operating characteristic (ROC) analysis also highlighted the let-7f-5p and miR3p potential as robustness plasma biomarkers for diagnosis and potential therapeutic targets of sALS disease. +lncRNA target 35082283 hsa-mir-29a Stomach Neoplasms LncRNA NR2F1-AS1 plays crucial roles in GC progression by modulating miR-29a-3p/VAMP7 axis, suggesting that NR2F1-AS1 may serve as a potential therapeutic target in GC. +lncRNA target 35081873 hsa-mir-125a Carcinoma, Hepatocellular MiR-125a-5p was downregulated in HCC cells and a target of CYTOR in regulating HCC progression. +lncRNA target 35081872 hsa-mir-326 Carcinoma, Non-Small-Cell Lung Besides, PCAT6 could directly target miR-326 in gefitinib-resistant NSCLC cells and augment NSCLC resistance to gefitinib by serving as ceRNA of miR-326. Our investigation identified that PCAT6 enhanced gefitinib resistance of NSCLC via miR-326/IFNAR2 axis, which might offer a new therapeutic strategy against gefitinib resistance of NSCLC patients. +lncRNA target 35081869 hsa-mir-1245a Carcinoma, Non-Small-Cell Lung In conclusion, circ_0006677 regulated SATB2-mediated tumor-suppressive effect via acting as a miR-1245a sponge in NSCLC, providing a new mechanism for understanding the progression of NSCLC. +other 35081862 hsa-mir-217 Angelman Syndrome All in all circ_0033596 aggravates ox-LDL-induced HUVEC apoptosis by regulating the miR5p/CLIC4 axis, by which circ_0033596 participates in the pathogenesis of AS. +lncRNA target 35081855 hsa-mir-656 Colorectal Neoplasms 3p could regulate cell proliferation and chemoresistance in the colorectal cancer that associate to downstream target with SGPP1. +other 35081125 hsa-mir-122 Carcinoma, Hepatocellular In addition, the levels of tumor markers including alpha-fetoprotein, arginase-1, alpha-L-fucosidase, and ferritin were significantly increased, whereas the hepatic miR-122 level was significantly decreased in induced-HCC rats. +genetics_knock down_promote 35080988 hsa-mir-588 Nasopharyngeal Carcinoma Inhibition of miR-588 could partially reverse the knockdown of SNHG8 in NC cells, and miR-588 targeted HMGA2. In conclusion, SNHG8 promotes proliferation, migration, and invasion of NC cells through miR-588/HMGA2 in NC as an oncogene. +other 35080329 hsa-mir-557 Carcinoma, Hepatocellular The expression levels of circ_0040705 and SOX2 mRNA were markedly increased in HCC tissues, but miR-557 expression was down-regulated. Circ_0040705 facilitates HCC cell growth, migration, and invasion by down-modulating miR-557 expression and up-modulating SOX2 expression. +genetics_overexpression_suppress 35080031 hsa-mir-101 Carcinoma, Hepatocellular 3p inhibition or WEE1 overexpression could reverse the effect of Verbascoside on the viability and apoptosis of HCC cells. +circulation_biomarker_diagnosis_up 35079982 hsa-mir-155 Carotid Stenosis Compared with those of the NC group, the expression of miR-155 in the miR-155 mimic group increased significantly (P < 0.05), the degree of carotid plaque formation increased, the plasma levels of TC and LDL also increased significantly (P < 0.05); the expression levels of NLRP3 inflammasome-related proteins, interleukin-1beta, interleukin-18, and MEK/ERK/NF-kappaB signaling pathway-related proteins were also significantly increased. +other 35079927 hsa-mir-661 Lymphoma, B-Cell Transcriptional and translational levels of circPDE7B, microRNA (miR)-661, fibroblast growth factor 2 (FGF2), cleaved caspase3, B-cell lymphoma (bcl)-2, and bclassociated X protein (bax) were detected by real-time quantitative PCR and western blotting. +lncRNA target 35079927 hsa-mir-661 Keloid Expression of circPDE7B was upregulated in human keloid tissues and HKFs, accompanied with miR-661 downregulation and FGF2 upregulation. In conclusion, circPDE7B might contribute to HKFs progression via functioning as ceRNA for miR-661, suggesting a novel circPDE7B/miR-661/FGF2 pathway underlying keloid formation and treatment. +genetics_knock down_promote 35079927 hsa-mir-661 Hyalinosis, Systemic Deleting miR-661 and re-expressing FGF2 both abrogated the suppression of circPDE7B knockdown in HKFs progression. +genetics_overexpression_promote 35079913 hsa-mir-200c Thyroid Cancer, Papillary The effects of miR-200c-3p mimics on promoting the malignant behaviors of PTC cells were remarkably reversed by the overexpression of ATP2A2, as a downstream target of miR-200c-3p. +other 35079871 hsa-mir-613 Neurogenic Inflammation Altogether, these results suggest that lncRNA MIAT functioned as a ceRNA for miR-613 to modulate NFAT5 expression in LPS-induced BV2 cells, which may contribute to a better understanding of the mechanism of neuroinflammatory diseases. +other 35079352 hsa-mir-221 Breast Neoplasms CONCLUSION: miR-221 expression was higher in tamoxifen-resistant BC cases. +circulation_biomarker_diagnosis_up 35079347 hsa-mir-29b Asthma RESULTS: MiR-29b levels were decreased in the peripheral blood mononuclear cells from children with asthma. +genetics_GWAS 35079080 hsa-mir-34b Squamous Cell Carcinoma of Head and Neck Pre-miR-34b/c polymorphism was not associated with oral cancer risk. +other 35079043 hsa-mir-144 Parkinson Disease These promising results ask for further research to unveil the functional details of the involvement of hsa-mir144-3p in Parkinson's Disease. +other 35078502 hsa-mir-29c Carcinoma, Ductal, Breast Furthermore, we identified that miR-29c negatively regulated a stemness promoting gene, ID2, and diminished self-renewal ability of DCIS cells. CONCLUSION: Our findings revealed a critical role of the IPW-miR-29c-ID2 axis in DCIS formation and suggested potential clinical use of toyocamycin for the treatment of DCIS. +genetics_overexpression_promote 35078498 hsa-mir-497 Ovarian Neoplasms Studies have demonstrated that overactivation of the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway is involved in tumor chemoresistance and that overexpression of microRNA-497 (miR497) may overcome OC chemotherapy resistance by inhibiting the mTOR pathway. RESULTS: Herein, whether the combined application of miR497 and TP could further overcome OC chemoresistance by synergically suppressing the mTOR signaling pathway was investigated. +genetics_overexpression_promote 35078194 hsa-mir-155 Carcinoma, Renal Cell RESULTS: Experimental data suggested that overexpression or silencing of microRNA +lncRNA target 35077859 hsa-mir-486 Myocardial Reperfusion Injury In conclusion, miR-486 is protective against cardiac I/R injury and myocardial apoptosis through targeting of PTEN and FoxO1 and activation of the AKT/mTOR pathway, and mediates the beneficial effect of exercise for myocardial protection. Increasing miR-486 might be a promising therapeutic strategy for myocardial protection. +other 35077391 hsa-mir-98 pancreatic adenocarcinoma Moreover, CASKIN2, TLE2, USP20, SPRN, ARSG, MIR106B, and MIR98 might be associated with low-risk patients with PAAD. +other 35077391 hsa-mir-106b pancreatic adenocarcinoma Moreover, CASKIN2, TLE2, USP20, SPRN, ARSG, MIR106B, and MIR98 might be associated with low-risk patients with PAAD. +genetics_knock down_suppress 35076987 hsa-mir-877 Carcinoma, Non-Small-Cell Lung CONCLUSION: CircPRH1-PRR4 knockdown impeded NSCLC cell malignancy by the miR +lncRNA target 35076913 hsa-mir-4500 Glioma CONCLUSION: Down-regulating TTTY15 targeting miR-4500 can inhibit the proliferation, migration, invasion and induce apoptosis of the A172 glioma cells. +target gene 35076912 hsa-mir-7 Carcinoma, Non-Small-Cell Lung Silencing circ-SFMBT2 can suppress the proliferation, clone formation, invasion ability and induce apoptosis of NSCLC cells by regulating the miR-7-5p/ADAM10 axis. +other 35076836 hsa-mir-623 Carcinoma, Non-Small-Cell Lung RT-qPCR was carried out to detect CTBP1-AS2 and miR-623 expression in NSCLC cells and tissues. Moreover, the miR-623 level was lower in NSCLC specimens than in paired non-tumor specimens, and CTBP1-AS2 expression was negatively correlated with miR-623 expression in NSCLC samples. +other 35076819 hsa-mir-885 Alzheimer Disease These experimental data demonstrated that circ_0003611 enhanced the Abeta-induced neuronal cell injury in AD by serving as the miR5p sponge to regulate the level of KREMEN1. +circRNA target 35076816 hsa-mir-107 Inflammation Circ-LTBP1 was found to enhance DOX-induced effects on proliferation inhibition, inflammation, apoptosis, and oxidative stress in AC16 cells through competitively sponging miR-107 and elevating ADCY1. +other 35076814 hsa-mir-1249 Adenocarcinoma of Lung Our findings demonstrate that the circ_0010235/miR3p/HOXA13 axis is implicated in the pathogenesis of LUAD. +circulation_biomarker_diagnosis_ns 35076541 hsa-mir-27a Kidney Failure, Chronic We first determined the association between the vascular injury markers and specific heart conditions and observed that ESKD patients with coronary heart disease have significantly higher levels of circulating ADMA and miR-27a. +exosome 35076227 hsa-mir-129 Diabetes Mellitus, Type 1 miR-129 was shown as a candidate related to both resveratrol and wound healing in T1DM. Resveratrol exerts promotive role in wound healing in T1DM through downregulation of TRAF6 via MSC-EV-carried miR-129, suggesting a regulatory network involved in the wound healing process in T1DM. +circulation_biomarker_diagnosis_up 35076188 hsa-mir-21 Diabetes Mellitus, Type 2 miR-21 expression was positively associated with glycosylated hemoglobin (HbA1c), fasting blood sugar (FBS), and triglyceride (TG) and might have diagnostic value for T2DM and pre-T2DM. +circulation_biomarker_diagnosis_ns 35076182 hsa-mir-205 Lung Neoplasms The area under the ROC curve of serum miR +lncRNA target 35075728 hsa-mir-215 Inflammation Our findings provide a rationale for targeting miR-215 as a therapeutic intervention for inflammatory conditions in the small intestine. +transcription factor target 35075615 hsa-mir-375 Infertility It provides evidence that miR-375 is a negative regulator of decidualization and could serve as a potential target for combating infertility. +other 35075615 hsa-mir-375 Endometriosis Previous studies have revealed altered expression of miR-375 in the endometrium of patients with recurrent implantation failure and the ectopic stromal cells of patients with endometriosis. +genetics_overexpression_promote 35075610 hsa-mir-200b Endometriosis We found an upregulation of the miR-200b-3p in endometriosis MenSCs (P = 0.0207), with a 7.93-fold change (ratio of geometric means) compared to control. Overexpression of miR-200b has been associated with increased cell proliferation, stemness, and accentuated mesenchymal-epithelial transition process in eutopic endometrium of endometriosis. +genetics_overexpression_promote 35075603 hsa-mir-1 Esophageal Squamous Cell Carcinoma In ESCC cells, NRON overexpression decreased miR-31 expression, while miR-31 failed to alter NRON expression. +lncRNA target 35075548 hsa-mir-20 Depression 3p to target CRHR1. +lncRNA target 35075501 hsa-mir-185 Schizophrenia Nonetheless, the miR-185 expression profile and its corresponding target genes in animal models and patients with 22q11.2 deletion syndrome (22q11.2DS) imply that more study is required about miR-185 and its corresponding downstream pathways within idiopathic SCZ. Our findings suggest that gene expression alterations mediated by miR-185 may play a role in the pathogenesis of idiopathic and 22q11.2DS SCZ. +other 35075375 hsa-mir-133a Prostatic Neoplasms The most interesting 8 prognostic biomarkers for prostate cancer included lncRNA LINC01082, miRNA hsa-miR-133a-3p, and genes TTLL12, PTGDS, GAS6, CYP27A1, PKP3, and ZG16B. +target gene 35075362 hsa-mir-223 Uterine Cervical Neoplasms HDAC10 Inhibits Cervical Cancer Progression through Downregulating the HDAC10-microRNA-223-EPB41L3 Axis. +circulation_biomarker_diagnosis_up 35075166 hsa-mir-363 Pre-Eclampsia Serum miR-17, miR-363 and MALAT-1 could have utility as new biomarkers of PE diagnosis. +other 35075166 hsa-mir-17 Pre-Eclampsia In PE, miR-17 and MALAT-1 were significantly correlated with gestational age (r = - 0.328 and r = 0.322, respectively) and albuminuria (r = 0.312, and r = - 0.35, respectively). +exosome 35075150 hsa-mir-181a-2 Parkinson Disease Collectively, our findings revealed that MSC-derived EV-loaded miR-181a +other 35075117 hsa-mir-4693 Colorectal Neoplasms miR5p was significantly downregulated in CRC tumor tissues and bound to the 3' untranslated region (3'UTR) of TRIP13, downregulating TRIP13 expression. +circulation_biomarker_diagnosis_ns 35075115 hsa-mir-582 Prostatic Neoplasms Mechanistically, DLEU2 promoted serum and glucocorticoid-induced protein kinase 1 (SGK1) expression by acting as an miR +other 35074681 hsa-mir-21 Lung Neoplasms Paper-based electrodes modified with molybdenum disulfide (MoS(2)) in the form of bulk crystals or exfoliated nanosheets were developed and used as a biosensing platform for the impedimetric detection of miRNAs (miRNA-155 and miRNA-21) related to early diagnosis of lung cancer. +other 35074681 hsa-mir-155 Lung Neoplasms Paper-based electrodes modified with molybdenum disulfide (MoS(2)) in the form of bulk crystals or exfoliated nanosheets were developed and used as a biosensing platform for the impedimetric detection of miRNAs (miRNA-155 and miRNA-21) related to early diagnosis of lung cancer. +genetics_overexpression_promote 35074616 hsa-mir-197 Multiple Myeloma Overexpression of miR +circulation_biomarker_diagnosis_ns 35074547 hsa-mir-140 Osteoarthritis METHOD: Primary (passage 1/2) human OA chondrocytes were isolated from arthroplasty samples (six donors) and transfected with ribonuclear protein complexes or plasmids using single guide RNAs (sgRNAs) targeting miR-140, in combination with Cas9 endonuclease. +circRNA target 35074490 hsa-mir-599 Absent corpus callosum cataract immunodeficiency CONCLUSION: CircANKRD36 can inhibit the expression of miR-599 and the activation of TGF-beta signaling pathway, thus inhibiting the expression of differentiation-related factors of VIC osteogenesis and the formation of calcified nodules. +other 35074490 hsa-mir-599 autosomal recessive congenital bilateral absence of vas deferens TGF-beta axis can be a new theoretical basis for treating CAVD. +exosome 35073936 hsa-mir-494 Carcinoma, Hepatocellular 3p expression level in exosomes derived from HCC cells without affecting total cellular miR +other 35073841 hsa-mir-133b Esophageal Neoplasms Both CREB1 and miR-133b was involved in the beta3GNT2-mediated ESCA progression. +genetics_overexpression_suppress 35073820 hsa-mir-26a Nasopharyngeal Carcinoma The overexpression of miR-26a-5p inhibited the viability, proliferation, migration, and invasion of NPC cells. +other 35073575 hsa-mir-222 Diabetes Mellitus, Type 2 3p: HR 1.97, P = 9.10E-03) in the highest versus lowest tertile of expression. +other 35073542 hsa-mir-34b Hypoxia-Ischemia, Brain 5p at the time of admission to the NICU. +other 35073542 hsa-mir-338 Hypoxia-Ischemia, Brain 5p at the time of admission to the NICU. +other 35073542 hsa-mir-142 Hypoxia-Ischemia, Brain 5p at the time of admission to the NICU. +other 35073542 hsa-mir-497 Hypoxia-Ischemia, Brain 5p at the time of admission to the NICU. +other 35073542 hsa-mir-145 Hypoxia-Ischemia, Brain At 48 h, infants suffering from moderate/severe HIE with a poor long-term neurodevelopmental outcome showed a significant increase in hsa-mir5p. +other 35073542 hsa-mir-98 Hypoxia-Ischemia, Brain 5p at the time of admission to the NICU. +lncRNA target 35072892 hsa-mir-153 Colorectal Neoplasms Finally, ARCR suppressed the polarization of M2 macrophages to inhibit the tumor growth and tumor metastasis in CRC by mediating the Sp1/ZFAS1/miR +lncRNA target 35072651 hsa-mir-203a Nasopharyngeal Carcinoma Furthermore, miR-203a-3p regulated the PI3K/AKT signal pathway by downregulating the expression of VEGF-C, thereby inhibiting the proliferation, migration, invasion, vasculogenic mimicry, epithelial-mesenchymal transition, and other malignant biological characteristics of nasopharyngeal carcinoma cells. +genetics_overexpression_promote 35072529 hsa-mir-582 Nasopharyngeal Carcinoma In the final rescue assays, we observed that the effect of HOXA10-AS depletion on NPC cell growth could be fully reversed by RAB31 overexpression or miR +other 35072021 hsa-mir-19b Non-alcoholic Fatty Liver Disease Relative to NAFL/non-alcoholic steatohepatitis (NASH) with mild fibrosis (stage 0/1), 3 miRNAs (miR-193a-5p, miR-378d, and miR378d) were increased in cases with NASH and clinically significant fibrosis (stages 2-4), 7 (miR193a-5p, miR-378d, miR-378e, miR-320b, miR-320c, miR-320d, and miR-320e) increased in cases with NAFLD activity score (NAS) 5-8 compared with lower NAS, and 3 (miR-193a-5p, miR-378d, and miR-378e) increased but 1 (miR-19b-3p) decreased in steatosis, activity, and fibrosis (SAF) activity score 2-4 compared with lower SAF activity. +other 35072021 hsa-mir-320c Non-alcoholic Fatty Liver Disease Relative to NAFL/non-alcoholic steatohepatitis (NASH) with mild fibrosis (stage 0/1), 3 miRNAs (miR-193a-5p, miR-378d, and miR378d) were increased in cases with NASH and clinically significant fibrosis (stages 2-4), 7 (miR193a-5p, miR-378d, miR-378e, miR-320b, miR-320c, miR-320d, and miR-320e) increased in cases with NAFLD activity score (NAS) 5-8 compared with lower NAS, and 3 (miR-193a-5p, miR-378d, and miR-378e) increased but 1 (miR-19b-3p) decreased in steatosis, activity, and fibrosis (SAF) activity score 2-4 compared with lower SAF activity. +other 35072021 hsa-mir-320d Non-alcoholic Fatty Liver Disease Relative to NAFL/non-alcoholic steatohepatitis (NASH) with mild fibrosis (stage 0/1), 3 miRNAs (miR-193a-5p, miR-378d, and miR378d) were increased in cases with NASH and clinically significant fibrosis (stages 2-4), 7 (miR193a-5p, miR-378d, miR-378e, miR-320b, miR-320c, miR-320d, and miR-320e) increased in cases with NAFLD activity score (NAS) 5-8 compared with lower NAS, and 3 (miR-193a-5p, miR-378d, and miR-378e) increased but 1 (miR-19b-3p) decreased in steatosis, activity, and fibrosis (SAF) activity score 2-4 compared with lower SAF activity. +other 35072021 hsa-mir-20b Non-alcoholic Fatty Liver Disease Relative to NAFL/non-alcoholic steatohepatitis (NASH) with mild fibrosis (stage 0/1), 3 miRNAs (miR-193a-5p, miR-378d, and miR378d) were increased in cases with NASH and clinically significant fibrosis (stages 2-4), 7 (miR193a-5p, miR-378d, miR-378e, miR-320b, miR-320c, miR-320d, and miR-320e) increased in cases with NAFLD activity score (NAS) 5-8 compared with lower NAS, and 3 (miR-193a-5p, miR-378d, and miR-378e) increased but 1 (miR-19b-3p) decreased in steatosis, activity, and fibrosis (SAF) activity score 2-4 compared with lower SAF activity. +circulation_biomarker_diagnosis_ns 35072021 hsa-mir-193a Non-alcoholic Fatty Liver Disease CONCLUSIONS: Serum miR-193a-5p levels correlate strongly with NAFLD activity grade and fibrosis stage. +other 35072021 hsa-mir-378e Non-alcoholic Fatty Liver Disease Relative to NAFL/non-alcoholic steatohepatitis (NASH) with mild fibrosis (stage 0/1), 3 miRNAs (miR-193a-5p, miR-378d, and miR378d) were increased in cases with NASH and clinically significant fibrosis (stages 2-4), 7 (miR193a-5p, miR-378d, miR-378e, miR-320b, miR-320c, miR-320d, and miR-320e) increased in cases with NAFLD activity score (NAS) 5-8 compared with lower NAS, and 3 (miR-193a-5p, miR-378d, and miR-378e) increased but 1 (miR-19b-3p) decreased in steatosis, activity, and fibrosis (SAF) activity score 2-4 compared with lower SAF activity. +other 35072021 hsa-mir-320e Non-alcoholic Fatty Liver Disease Relative to NAFL/non-alcoholic steatohepatitis (NASH) with mild fibrosis (stage 0/1), 3 miRNAs (miR-193a-5p, miR-378d, and miR378d) were increased in cases with NASH and clinically significant fibrosis (stages 2-4), 7 (miR193a-5p, miR-378d, miR-378e, miR-320b, miR-320c, miR-320d, and miR-320e) increased in cases with NAFLD activity score (NAS) 5-8 compared with lower NAS, and 3 (miR-193a-5p, miR-378d, and miR-378e) increased but 1 (miR-19b-3p) decreased in steatosis, activity, and fibrosis (SAF) activity score 2-4 compared with lower SAF activity. +lncRNA target 35071928 hsa-mir-141 Prostatic Neoplasms Oncogenic and tumor suppressor miRNAs let-7a, let-7c, miR-200b, miR-141, and miR-21 were tested as predictive cancer biomarkers since multianalyte detection minimizes false-positive and false-negative rates and establishes a strong foundation for early PCa diagnosis. +lncRNA target 35071928 hsa-mir-21 Prostatic Neoplasms Oncogenic and tumor suppressor miRNAs let-7a, let-7c, miR-200b, miR-141, and miR-21 were tested as predictive cancer biomarkers since multianalyte detection minimizes false-positive and false-negative rates and establishes a strong foundation for early PCa diagnosis. +lncRNA target 35071928 hsa-let-7c Prostatic Neoplasms Oncogenic and tumor suppressor miRNAs let-7a, let-7c, miR-200b, miR-141, and miR-21 were tested as predictive cancer biomarkers since multianalyte detection minimizes false-positive and false-negative rates and establishes a strong foundation for early PCa diagnosis. +lncRNA target 35071928 hsa-mir-200b Prostatic Neoplasms Oncogenic and tumor suppressor miRNAs let-7a, let-7c, miR-200b, miR-141, and miR-21 were tested as predictive cancer biomarkers since multianalyte detection minimizes false-positive and false-negative rates and establishes a strong foundation for early PCa diagnosis. +lncRNA target 35071928 hsa-let-7a Prostatic Neoplasms Oncogenic and tumor suppressor miRNAs let-7a, let-7c, miR-200b, miR-141, and miR-21 were tested as predictive cancer biomarkers since multianalyte detection minimizes false-positive and false-negative rates and establishes a strong foundation for early PCa diagnosis. +lncRNA target 35071776 hsa-mir-199a Leiomyoma These findings broaden the current findings on the function of miR-199a-5p into the ULM pathogenesis, and miR-199a-5p may serve as a prognosis and therapeutic target for the ULM and its related diseases. +genetics_overexpression_promote 35071744 hsa-mir-23a-2 Carcinoma, Non-Small-Cell Lung In addition, in vitro and in vivo experiments show that overexpression or inhibition of all miRNAs in the miR-23a/27a/24-2 cluster significantly stimulated or inhibited NSCLC cell stemness, tumorigenicity and metastasis. +circulation_biomarker_diagnosis_up 35071600 hsa-mir-126 Hypertension We evaluated the effects of MitoQ supplementation and endurance training (ET), alone and in combination, on functional indices of the heart and serum levels of miR-126, miR-27a, antioxidants, and NO, in patients with HTN. +circulation_biomarker_diagnosis_up 35071600 hsa-mir-27a Hypertension We evaluated the effects of MitoQ supplementation and endurance training (ET), alone and in combination, on functional indices of the heart and serum levels of miR-126, miR-27a, antioxidants, and NO, in patients with HTN. +genetics_knock down_promote 35071487 hsa-mir-629 Carcinoma, Non-Small-Cell Lung 5p inhibition or TXNIP overexpression. +circulation_biomarker_diagnosis_ns 35071475 hsa-mir-223 Cerebral Small Vessel Diseases CONCLUSIONS: The expression of plasma exosomal miRNA +genetics_overexpression_promote 35071464 hsa-mir-96 Ovarian Neoplasms GAS5 overexpression could significantly reduce OC cell proliferation and invasion ability via suppression of miR +target gene 35071456 hsa-mir-7641 Cerebral Small Vessel Diseases LncRNA MALAT1 induced by hyperglycemia promotes microvascular endothelial cell apoptosis through activation of the miR-7641/TPR axis to exacerbate neurologic damage caused by cerebral small vessel disease. +therapeutic target 35071455 hsa-let-7a Breast Neoplasms 5-FU@DHA-UIO-66-NH(2) potentiates chemotherapy sensitivity of breast cancer cells through a microRNA let-7a-dependent mechanism. +other 35071451 hsa-mir-611 Adenocarcinoma of Lung The expression of miR-3611, which is regulated by hsa_circ_0031968, was found to significantly affect the survival and prognosis of patients with LUAD (P/= 0.6: 20 had never been reported before; one (miR3p) had previously been observed in endometriosis; and the remaining 36 had been reported in benign and malignant disorders. +other 35054253 hsa-mir-222 Leukemia, Myeloid, Acute This is the first study focused on examining the GAS5 and miR-222 expression pattern in AML patients. +other 35053622 hsa-mir-566 Colorectal Neoplasms 1-3p and miR-566 enables noninvasive and early detection of CRC. +other 35053622 hsa-mir-129-1 Colorectal Neoplasms 1-3p and miR-566 enables noninvasive and early detection of CRC. +genetics_overexpression_promote 35053428 hsa-mir-21 Stomach Neoplasms MicroRNA-21 (miR-21) is a small, non-coding RNA overexpressed in gastric cancer and many other solid malignancies, where it exhibits both pro-and anti-tumourigenic properties. +other 35053317 hsa-mir-214 Kartagener Syndrome 5p) of DPC-EVs revealed similarities between P4 DPC-EVs-treated ASCs and DPCs. +other 35053317 hsa-mir-218 Kartagener Syndrome 5p) of DPC-EVs revealed similarities between P4 DPC-EVs-treated ASCs and DPCs. +other 35053317 hsa-mir-195 Kartagener Syndrome 5p) of DPC-EVs revealed similarities between P4 DPC-EVs-treated ASCs and DPCs. +other 35052873 hsa-mir-122 Non-alcoholic Fatty Liver Disease The expressions of miR-122, -192, and 3p were quantified in total cell-free RNA, global EVs, and liver-specific EVs from control, NAFL, and NASH subjects. +other 35052821 hsa-mir-200c Colorectal Neoplasms miR-200c showed a positive correlation with DCN, and the aforementioned lncRNAs exhibited a significant positive correlation with miR-200c expression in metastatic CRC. Our results suggest that DCN as well as miR-200c, MALAT1, lncTCF7 and ZFAS1 contribute to the development of metastases in CRC and that regulation of DCN expression in CRC by ncRNAs is accomplished in an indirect manner. +other 35052815 hsa-mir-146a Neurogenic Inflammation Increased expression of the full miR-146a profile, and 3'tRF-IleAAT and 3'tRF-LysTTT was associated with a worse behavioral outcome in animals with chronic neuroinflammation. +other 35052815 hsa-mir-146a Chronic Disease Increased expression of the full miR-146a profile, and 3'tRF-IleAAT and 3'tRF-LysTTT was associated with a worse behavioral outcome in animals with chronic neuroinflammation. +lncRNA target 35052738 hsa-mir-92a Diabetes Complications Furthermore, additional analysis of potential in silico-identified miR-92a targets in diabetic HCMEC revealed the miR-92a dependent downregulation of an essential metalloprotease, ADAM10. +lncRNA target 35052738 hsa-mir-92a Diabetes Mellitus Furthermore, additional analysis of potential in silico-identified miR-92a targets in diabetic HCMEC revealed the miR-92a dependent downregulation of an essential metalloprotease, ADAM10. +lncRNA target 35052701 hsa-mir-671 Glioblastoma 5p inhibition to increasing STAT3 and TRAF2 presentation. +circulation_biomarker_diagnosis_ns 35052352 hsa-mir-4798 Atrial Fibrillation CONCLUSIONS: Plasma levels of miR +other 35051729 hsa-mir-196a Barrett Esophagus In contrast, miR-196a-5p is confirmed as a specific BE marker. +circRNA target 35051313 hsa-mir-520c Carcinoma, Hepatocellular miR-520c-3p sponged by circKCNN2 could reverse the inhibitory effect of circKCNN2 on HCC cells and down-regulate the expression of methyl-DNA-binding domain protein 2 (MBD2). CONCLUSIONS: circKCNN2, transcriptionally repressed by NFYA, suppresses HCC recurrence via the miR-520c-3p/MBD2 axis. +genetics_overexpression_suppress 35050556 hsa-mir-1321 Carcinoma, Non-Small-Cell Lung Functional rescue experiments showed that CDC20 overexpression averted the anti-tumor effects of miR-1321 and miR-7515 on NSCLC cells. +genetics_overexpression_suppress 35050556 hsa-mir-7515 Carcinoma, Non-Small-Cell Lung Functional rescue experiments showed that CDC20 overexpression averted the anti-tumor effects of miR-1321 and miR-7515 on NSCLC cells. +lncRNA target 35050465 hsa-mir-149 Stomach Neoplasms Overall, OGFRP1 was determined to promote GC cell proliferation while suppressing cell apoptosis and radiosensitivity by regulating the miR +transcription factor target 35050429 hsa-mir-4510 Stomach Neoplasms Oxaliplatin treatment may become a specific therapeutic drug for patients with miR-4510 inhibition and GPC3-GC. +genetics_knock down_promote 35050425 hsa-mir-1294 Mesothelioma, Malignant MiR-1294 restoration also suppressed the proliferation, migration, invasion and stemness of MPM cells, while these effects were abolished by HMGA1 overexpression. CircPLK1 knockdown inhibited MPM cell proliferation, migration, invasion and stemness by targeting the miR-1294/HMGA1 pathway. +circulation_biomarker_diagnosis_ns 35049226 hsa-mir-148 Carcinoma, Non-Small-Cell Lung OBJECTIVE: To evaluate the diagnostic value of the blood miR-148/152 family to NSCLC by meta-analysis. +circulation_biomarker_diagnosis_ns 35049226 hsa-mir-152 Carcinoma, Non-Small-Cell Lung OBJECTIVE: To evaluate the diagnostic value of the blood miR-148/152 family to NSCLC by meta-analysis. +lncRNA target 35049152 hsa-mir-137 late onset Parkinson's disease Collectively, lncRNA OIP5-AS1 promoted NIX expression through competitively binding to miR-137, and promoted mitochondrial autophagy, thus protecting neurons from degeneration which might be seen in patients with PD. +epigenetics 35049148 hsa-mir-424 Carcinoma, Hepatocellular 5p promoter methylation reduced miR +genetics_overexpression_promote 35048795 hsa-mir-133b Uterine Cervical Neoplasms miR-133b was overexpressed or silenced in the cervical cancer cell line C33A. +other 35048790 hsa-mir-502 Carcinoma, Hepatocellular This study demonstrated that the circ-SOX5/miR5p/SYVN1 axis promotes the development of HCC by regulating cell apoptosis. +other 35048507 hsa-mir-149 Triple Negative Breast Neoplasms 5p to increase CDT1 expression. +other 35048477 hsa-mir-1276 Urinary Bladder Neoplasms The regulatory effects of circ_0002623 and miR-1276 on the expression levels of TGF-beta, WNT1, and SMAD2 in BCa cells were detected by Western blot. We reported that, in BCa tissues and cell lines, circ_0002623 was upregulated, whereas miR-1276 was downregulated. +lncRNA target 35048354 hsa-mir-20b Stomach Neoplasms Finally, rescue assays demonstrated that NR2F2-AS1 down-regulated PDCD4 expression to restrain the development of gastric cancer by competitively binding to miR-320b. On the whole, our study revealed the role of NR2F2-AS1/miR-320b/PDCD4 regulatory network in gastric cancer, suggesting NR2F2-AS1 may represent a novel therapeutic target for patients with gastric carcinoma. +other 35048271 hsa-mir-370 Non-alcoholic Fatty Liver Disease CONCLUSION: Hepatic miR122-Let7 miRNA modulation could be the first insult to NAFLD development, preceding changes in glycemic homeostasis and adiposity. +other 35048271 hsa-let-7 Non-alcoholic Fatty Liver Disease CONCLUSION: Hepatic miR122-Let7 miRNA modulation could be the first insult to NAFLD development, preceding changes in glycemic homeostasis and adiposity. +other 35048092 hsa-mir-15a Carcinoma, Renal Cell Previous work on RCC demonstrated the miRNA15a to be reliable and novel biomarker with 98.1% specificity and 100% sensitivity. +circulation_biomarker_diagnosis_ns 35047559 hsa-mir-96 Colorectal Neoplasms The High Ratio of the Plasma miR-96/miR-99b Correlated With Poor Prognosis in Patients With Metastatic Colorectal Cancer. +circulation_biomarker_diagnosis_ns 35047559 hsa-mir-99b Colorectal Neoplasms The High Ratio of the Plasma miR-96/miR-99b Correlated With Poor Prognosis in Patients With Metastatic Colorectal Cancer. +transcription factor target 35047556 hsa-mir-587 Thyroid Cancer, Papillary In conclusion, these preliminary results indicate that inhibition of miR-3587 promotes HO-1 upregulation, thereby protecting renal tissues from IR-induced ferroptosis. +transcription factor target 35047452 hsa-mir-1246 Breast Neoplasms To determine the classification performance of a set of miRNA biomarkers (miR-1246, 202, 21, and 219B) useful for breast cancer screening, we determined whether there was a significant difference between the breast cancer and healthy control groups through box plots and the Mann-Whitney U-test, which was further examined in detail by age group. +transcription factor target 35047423 hsa-mir-222a Hepatitis A Moreover, upregulated miR-222a could negatively regulate DHAV-1 replication in DEFs and downregulate integrin subunit beta 3 (ITGB3) expression by targeting the 3' untranslated region (3'UTR), indicating that miR-222a may modulate DHAV-1 replication via interaction with ITGB3. In conclusion, the results reveal changes of mRNAs and miRNAs during DHAV-1 infection and suggest miR-222a as an antiviral factor against DHAV-1. +circulation_biomarker_prognosis_ns 35047407 hsa-mir-223 Uterine Cervical Neoplasms Elevated expressions of TPD52 and miR-223 and reduced expressions of KLF9 and PKC in peripheral blood of cervical cancer patients may serve as predictors of disease diagnosis and prognosis. +genetics_knock down_promote 35046889 hsa-mir-222 Tuberous Sclerosis Ddit4 is a direct target of Mir221 and Mir222, and the upregulation of Ddit4 in Mir221/222AdipoKO was associated with the suppression of TSC2 (tuberous sclerosis complex 2)/mammalian target of rapamycin complex 1 (mTORC1)/S6K (ribosomal protein S6 kinase) pathway. +genetics_knock down_promote 35046889 hsa-mir-221 Tuberous Sclerosis Ddit4 is a direct target of Mir221 and Mir222, and the upregulation of Ddit4 in Mir221/222AdipoKO was associated with the suppression of TSC2 (tuberous sclerosis complex 2)/mammalian target of rapamycin complex 1 (mTORC1)/S6K (ribosomal protein S6 kinase) pathway. +lncRNA target 35046806 hsa-mir-216a Atherosclerosis Conclusion: Our findings indicated that Rb2 might be a potential therapeutic molecule for atherosclerosis by attenuating the atherosclerosis plaque lesion, lipid accumulation, and M1 macrophages polarization by targeting miR-216a. +lncRNA target 35046724 hsa-mir-195 Carcinoma, Non-Small-Cell Lung CONCLUSION: Our findings suggest that miR-3195 may be used as a prognostic biomarker for NSCLC and is likely to act as a tumor suppressor for NSCLC. +circulation_biomarker_diagnosis_ns 35046680 hsa-mir-26a Diabetes Mellitus, Type 2 METHODS: Serum miR-26a-5p and RNF6 levels were detected in T2D patients and healthy volunteers via qRT-PCR. +transcription factor target 35046625 hsa-mir-217 Colitis CONCLUSION: The protective effects of rSj16 on colitis is related to apoptosis and miRNA5p may be a further target for therapeutic intervention against IBD. +circulation_biomarker_diagnosis_up 35046398 hsa-mir-130a Carcinoma, Hepatocellular Upon the determination of the optimal concentration of dexmedetomidine, HCCLM3 cells were treated with dexmedetomidine, miR-130a- or EGR1-related oligonucleotides or plasmids were transfected into cells to explore their functions in cell biological behaviors. +genetics_knock down_suppress 35046388 hsa-mir-135b Colorectal Neoplasms Knockdown of miR-135b decreased the expression level of SPOCK1, glucose consumption and lactic secretion in CRC patient-derived tumours organoids (CRC tPDOs). Thus, combination with miR-135b antisense nucleotides may represent a novel strategy to sensitise CRC to the chemo-reagent based treatment. +genetics_knock down_promote 35046387 hsa-mir-503 Carcinoma, Non-Small-Cell Lung NSCLC cell lines (A549 and H1299) were applied for loss-of-function and gain-of-function tests to identify the functional roles of JMJD2C, MALAT1, miR +lncRNA target 35045986 hsa-mir-183 Carcinoma, Hepatocellular These data support a model wherein circRPN2 inhibits HCC aerobic glycolysis and metastasis via acceleration of ENO1 degradation and regulation of the miR5p/FOXO1 axis, suggesting that circRPN2 represents a possible therapeutic target in HCC. +circulation_biomarker_diagnosis_up 35045800 hsa-mir-18a Arthritis, Rheumatoid Furthermore, lncRNA CASC2 and miR-18a-5p expression in the serum samples of RA patients and healthy controls were measured via reverse transcription-quantitative PCR. +other 35045793 hsa-let-7 Pinta The networks revealed 29 hub microRNAs (e.g., Let-7 family, miR3p.) and 19 hub tRFs (e.g., tRF3-Thr-AGT, i-tRF-Met-CAT) in PAITA. +transcription factor target 35045746 hsa-mir-383 Breast Neoplasms 5p, thereby inhibiting proliferative, migratory, and invasive abilities and promoting apoptosis of BC cells. +lncRNA target 35045733 hsa-mir-421 Carcinoma, Non-Small-Cell Lung Conclusion: MiR-421 promotes lipid metabolism through targeting PTEN via PI3K/AKT/mTOR pathway activation in NSCLC, indicating that miR-421 can be a latent therapeutic target for NSCLC. +transcription factor target 35045633 hsa-mir-181a Non-alcoholic Fatty Liver Disease miR-181a may affect the pathogenesis and progression of nonalcoholic fatty liver disease by inhibiting the expression of silencing information regulator 2 related enzyme 1. +genetics_knock down_promote 35045525 hsa-mir-1204 Colorectal Neoplasms CircITFG2 knockdown or miR-1204 overexpression abolished lidocaine-induced inhibition in proliferation, metastasis and promotion in apoptosis in CRC cells. +other 35045349 hsa-mir-885 Sensory ataxic neuropathy, dysarthria, and ophthalmoparesis CEND1 (fold change = 5.67) and miR885 (fold change = 8.91) were validated as having significantly different gene expressions between the SCA and NCA groups. +other 35045349 hsa-mir-885 Nasopharyngeal Carcinoma CEND1 (fold change = 5.67) and miR885 (fold change = 8.91) were validated as having significantly different gene expressions between the SCA and NCA groups. +genetics_knock down_suppress 35044621 hsa-mir-92a-2 Myocardial Infarction MiR-92a-2 overexpression significantly enhanced the protective effect of HOTTIP knockdown against AMI through partially inhibiting c-Met expression. Our results demonstrated that HOTTIP downregulation attenuated AMI progression via the targeting miR-92a-2/c-Met axis and suggested that HOTTIP might be a potential therapeutic target for AMI. +other 35044282 hsa-mir-199a Leukemia, Myeloid, Acute In this series, decreased expression of miR199a was associated with inadequate treatment response and worse OS in pediatric AML patients, indicating its potential as a prognostic biomarker for pediatric AML.Supplemental data for this article is available online at https://doi.org/10.1080/08880018.2021.2022045. +transcription factor target 35044231 hsa-mir-192 Diabetes Complications CSE/H(2)S/YB-1/Drosha/miR-192 is a potential therapeutic target pathway for treating diseases, including organ ischemia and diabetic complications. +circulation_biomarker_diagnosis_ns 35044231 hsa-mir-192 Plaque, Atherosclerotic In human atherosclerotic plaques, miR-192 levels were positively correlated with the plasma H(2)S concentrations. +circRNA target 35044104 hsa-mir-598 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: Our results revealed that circ_0007580 might be a target for improving the radiosensitivity of NSCLC, which was mainly achieved by regulating the miR-598/THBS2 axis. +lncRNA target 35043728 hsa-mir-490 Pancreatic Carcinoma 5p played an anti-cancer role in pancreatic cancer by targeting MAGI2-AS3 and regulating epithelial-mesenchymal transition (EMT), which was partially offset by MAGI2-AS3. +transcription factor target 35043644 hsa-mir-431 Myocardial Infarction, Acute 5p protected cardiomyocytes from AMI injury via restoring the expression of SELT, providing new ideas for the treatment of AMI. +other 35042949 hsa-mir-340 Hypertension, Pulmonary These results provided evidences that miR5p regulated MFF-SIRT1/3 axis to improve mitochondrial homeostasis and proliferation-apoptosis imbalance of hypoxia-treated PAMSCs, which provided a theoretical basis for the prevention and treatment of PAH. +circulation_biomarker_diagnosis_ns 35042243 hsa-mir-10a Lung Neoplasms This study assessed the action of dexmedetomidine (DEX) on oxidative stress (OS) and microRNA 10a (miR-10a) in patients with lung cancer. CONCLUSION: DEX can reduce postoperative OS and plasma miR-10a level in patients with lung cancer, and high expression of miR-10a predicts a high incidence of postoperative pulmonary complications. +lncRNA target 35042223 hsa-mir-466 Carcinoma, Non-Small-Cell Lung The potential miR involved in the chemo-resistance of NSCLC cells was explored via a series of bioinformatics analyses, and miR-466 was selected. +exosome 35042119 hsa-mir-223 Arthritis, Rheumatoid AIMS: The current research aimed to investigate the therapeutic effect of microRNA (miR)-223 in exosomes secreted by BMSCs on immune response in the progression of RA. CONCLUSION: Taken together, these findings suggest that miR-223 carried by BMSCs-derived exosomes targets NLRP3 to regulate the activation of inflammasomes, which therefore can be served as a possible therapy for RA. +other 35041823 hsa-mir-122 Esophageal Squamous Cell Carcinoma Additionally, LINC01410/miR5p/PKM2 axis affecting ESCC metastasis and EMT in vitro and in vivo. +transcription factor target 35041806 hsa-mir-19b Cognition Disorders These in vivo and in vitro findings indicate that the upregulation of miR-19b-3p exacerbates CRS-induced abnormal synaptic plasticity and cognitive impairment by targeting Drebrin. +transcription factor target 35041806 hsa-mir-19b Rubella Syndrome, Congenital These in vivo and in vitro findings indicate that the upregulation of miR-19b-3p exacerbates CRS-induced abnormal synaptic plasticity and cognitive impairment by targeting Drebrin. +other 35041543 hsa-mir-203 Carcinoma, Non-Small-Cell Lung 3p to promote NSCLC development. +circRNA target 35041407 hsa-mir-181d Myocardial Reperfusion Injury Silencing of circ_ZNF512 attenuated its binding to miR-181d-5p, which in turn impaired the EGR1 expression by targeting its 3'-UTR, thus promoting the autophagy of cardiomyocytes and suppressing cell apoptosis to alleviate myocardial tissue injury. +circulation_biomarker_diagnosis_ns 35041299 hsa-mir-181a Colorectal Neoplasms Clinically, high levels of serum EV containing miR-181a-5p was positively correlated with liver metastasis in CRC patients. +lncRNA target 35041255 hsa-mir-138 Non-alcoholic Fatty Liver Disease 5p inhibitor also promoted lipid metabolism and inhibited inflammatory response in NAFLD via PGC-1alpha activation. +genetics_overexpression_promote 35040749 hsa-let-7g Cholangiocarcinoma This study aimed to identify the mechanisms of long non-coding RNA (lncRNA) TMPO Antisense RNA 1 (TMPO-AS1), microRNA let-7 g-5p, and high-mobility group A1 (HMGA1) proteins in CHOL. Our results, through quantitative real-time PCR and Western blot detection, showed that TMPO-AS1 and HMGA1 were overexpressed while let-7 g-5p was underexpressed in CHOL. +circRNA target 35040370 hsa-mir-339 Osteoporosis Overall, this study uncovered the role of circ_0001795/miR5p/YAP1 axis in regulating osteogenic differentiation, indicating that targeting Circ_0001795 could serve as a novel therapeutic target for OP. +circulation_biomarker_diagnosis_up 35040271 hsa-mir-181b Small Cell Lung Carcinoma METHODS: Blood samples were collected from 30 SCLC patients and 30 non-SCLC patients in our department from 2017 to 2019 to detect the expression level of miR-181b.The expression level of miR-181b was detected in SCLC cells by RT-PCR, and screening of downstream target genes by gene chip, verification with luciferase, and Western blotting. +lncRNA target 35040191 hsa-mir-4726 Carcinoma, Hepatocellular Taken together, our study revealed that SM inhibited the growth of HCC and enhanced the anticancer effect of SF through HOTTIP-TUG1/miR5p/MUC1 signaling pathway. +genetics_knock down_suppress 35039981 hsa-mir-377 Neuroblastoma CircKIF2A knockdown impedes cell proliferation, metastasis, and glycolysis partly by regulating the miR +genetics_knock down_promote 35039980 hsa-mir-30 Colorectal Neoplasms 5p overexpression or circ_0000467 knockdown on CRC cell progression. +other 35039944 hsa-mir-298 COVID-19 We propose that our results convincingly suggest that circ_3205 is a circRNA synthesized by SARS-CoV-2 upon host cell infection and that it may behave as a competitive endogenous RNA (ceRNA), sponging hsa-miR-298 and contributing to the upregulation of KCNMB4 and PRKCE mRNAs. +genetics_knock down_promote 35039938 hsa-mir-221 Mucocutaneous Lymph Node Syndrome 3p had a better value for diagnosis IVIG resistance in children with KD than Kobayashi Score with the AUC of 0.811 (95% CI, 0.672-0.951), 0.793 (95% CI, 0.618-0.968), respectively. +lncRNA target 35039898 hsa-mir-27a Glioblastoma CONCLUSION: GBM-derived EVs were internalized by GBM cells, released miR-27a-3p into GBM cells, upregulated miR-27a-3p expression, and targeted BTG2, thus promoting TMZ resistance. +lncRNA target 35039872 hsa-mir-141 Pancreatic Carcinoma Reverse transcriptionquantitative PCR was performed to assess the expression levels of CTBP1AS2, microRNA (miR)1413p and ubiquitinspecific protease 22 (USP22) mRNA in pancreatic carcinoma tissues and cell lines. In conclusion, lncRNA CTBP1AS2 may be involved in pancreatic carcinoma progression by regulating miR1413p and USP22 expressions; in addition, CTBP1AS2 may be a diagnostic biomarker and treatment target for pancreatic carcinoma. +lncRNA target 35039758 hsa-mir-345 Intervertebral Disc Degeneration Circ_0004354 might compete with circ_0040039 to induce the development of IVDD by modulating miR3p-FAF1/TP73 axis-mediated PAoptosis, inflammatory response, growth inhibition, and ECM degradation of NPCs. +transcription factor target 35039635 hsa-mir-378a Prostatic Neoplasms Our data provides a rational for a new PCa stratification strategy based on miR expression, and it reveals that miR-378a and GLUT1 are potential therapeutic targets in highly aggressive glycolytic PCa. +circulation_biomarker_diagnosis_up 35039547 hsa-mir-548j Peripheral Arterial Disease Our results demonstrated that circulating miR-548j-5p was significantly reduced in patients with PAD as compared with the controls. In conclusion, our data indicated that up-regulation of miR-548j-5p promotes angiogenesis in ischemic tissue and may represent a novel therapeutic approach for PAD. +other 35039478 hsa-mir-618 Stomach Neoplasms Additionally, upregulation of EDDM3A in GC is at least partially mediated by downregulation of miR-618. +lncRNA target 35038955 hsa-mir-665 Non-alcoholic Fatty Liver Disease 3p as an endogenous positive regulator of NAFLD via inactivating FNDC5/AMPKalpha pathway, and inhibiting miR +genetics_overexpression_promote 35038953 hsa-mir-1287 Osteosarcoma Overexpression of miR +lncRNA target 35038704 hsa-mir-494 Diabetic Nephropathies 3p aggravates renal fibrosis, EMT process, and cell apoptosis by targeting SOCS6, suggesting that the miR +lncRNA target 35038619 hsa-mir-545 Carcinoma, Non-Small-Cell Lung Dual-inhibition of circFOXO3 and its target miRNAs suppressed the reduction of cell proliferation, migration and invasion induced by siRNA of circFOXO3 (si-circFOXO3), demonstrating that the effect of circFOXO3 on NSCLC was dependent on sponging miR +exosome 35038580 hsa-mir-141 Urinary Bladder Neoplasms In conclusion, exosome-derived circTRPS1 from BCa cells can modulate the intracellular reactive oxygen species (ROS) balance and CD8+ T cell exhaustion via the circTRPS1/miR141-3p/GLS1 axis. +lncRNA target 35038560 hsa-mir-34a Congenital central hypoventilation syndrome The objective of this study is to determine whether ethanol exposure can suppress NCC migration through inhibiting EMT and whether microRNA-34a (miR-34a) is involved in the ethanol-induced impairment of EMT in NCCs. +lncRNA target 35038081 hsa-mir-516b Glioma CircCCNB1 regulated glioma cell progression and CCND1 expression by miR-516b-5p and HuR. CircCCNB1 aggravated glioma cell growth by elevating CCND1 through targeting miR-516b-5p and HuR. +transcription factor target 35038059 hsa-mir-27a Multiple Myeloma METTL3 affected the growth, apoptosis, and stemness of MM cells through accelerating the stability of YY1 mRNA and the maturation of primary-miR-27a-3p in vitro and in vivo. +genetics_overexpression_promote 35037949 hsa-mir-1 Adenocarcinoma of Lung 5p on LUAD cell functions were attenuated by TNS1 overexpression to some extent. +lncRNA target 35037833 hsa-mir-195 Stomach Neoplasms In conclusion, LINC00662 facilitates the malignant biological behaviors of GC cells via miR5p/CEP55 axis, and therefore, it may be a promising target for GC treatment. +genetics_overexpression_promote 35037826 hsa-mir-648 Adenocarcinoma of Lung Overexpression of miR-3648 significantly enhanced cell proliferation, migration, and invasion abilities in LUAD cells. +circulation_biomarker_prognosis_up 35037761 hsa-mir-93 Colorectal Neoplasms The expression pattern of tissue and circulating miR +genetics_knock down_promote 35037694 hsa-mir-338 Squamous Cell Carcinoma of Head and Neck 3p can inhibit the proliferation of LSCC cells, while co-transfection of overexpression of ROR2 can partially reverse this change. +lncRNA target 35037556 hsa-mir-600 Carcinoma, Hepatocellular Our findings reveal the key role of LINC01273 in sorafenib-resistant HCC cells, and targeting of the newly identified LINC01273/miR-600/METTL3 feedback regulatory axis may be a promising effective intervention for HCC patients with sorafenib resistance. +genetics_knock down_promote 35037349 hsa-mir-924 Carcinoma, Non-Small-Cell Lung Moreover, the suppressive effect of miR-924 on NSCLC progression was reversed by SRSF7 overexpression. +genetics_GWAS 35037107 hsa-mir-34a Glioblastoma Our findings provide insight into understanding the molecular mechanism of GBM chemoresistance to TMZ and facilitating to develop novel treatment strategy to combat p53-mutant GBM by targeting miR-34a/WNT6 axis. +circRNA target 35037032 hsa-mir-382 Stomach Neoplasms Collectively, Circ_0000190 suppressed GC progression via miR +other 35036174 hsa-mir-21 Distal myopathy, Nonaka type chi-miR5p, ipu-miR-99b and bta-miR-26a were up-regulated in UM among the 10 most differentially expressed miRNAs. +lncRNA target 35036160 hsa-mir-15a Atrial Fibrillation Taken together, the miR-15a-5p/Smad7 pathway might be a potential target for AF therapy. +genetics_overexpression_promote 35036112 hsa-mir-100 Breast Neoplasms 5p overexpression or CDC25A suppression may contribute to BC diagnosis. +genetics_overexpression_promote 35036071 hsa-mir-874 Ventricular Premature Complexes 3p, the predicted target of circSmoc1-2, promotes VC, while overexpression of circSmoc1-2 reduces VC by suppressing miR +exosome 35036060 hsa-mir-9 Diabetic Retinopathy In this study, we demonstrated that exosomes collected from the vitreous humor of proliferative diabetic retinopathy patients promoted proliferation, migration and tube formation ability of primary human retinal endothelial cells via its elevated miR3p expression level. +lncRNA target 35036056 hsa-mir-17 Melanoma In this study, the results demonstrated that miR-17, which was downregulated in melanoma stem cells, acted as a tumor inhibitor by suppressing the stemness of melanoma stem cells and promoting cell differentiation. MiR-17 targeted ADAR2 (adenosine deaminase acting on RNA 2), a gene encoding an editing enzyme required for the maintenance of melanoma stem cell stemness. +lncRNA target 35035856 hsa-mir-372 Sepsis It is concluded that, in LPS-induced HK-2 cell injury, ZFAS1 has a protective role via modulating the miR3p/PPARalpha axis, suggesting the potential of ZFAS1 as a protective target for septic AKI. +lncRNA target 35035814 hsa-mir-20a Carcinoma, Non-Small-Cell Lung We concluded that LDLRAD3 exerted oncogenic effects via the miR-20a-5p-SLC7A5 axis to activate the mTORC1 signaling pathway in NSCLC. +other 35035811 hsa-mir-155 Gallbladder Neoplasms In this study, we have investigated the role and clinical significance of miR-155 in a Chinese population suffering from GBC and compared the results with nonneoplastic inflammation. +other 35035811 hsa-mir-145 Gallbladder Neoplasms Further results noted were that miR5p expressed genes mimic the gene expression of STAT1, a downregulation of IRF7 was noted in the GBC, and an activation of STAT1 was significantly noted in carcinoma cells of the gallbladder. +target gene 35035750 hsa-mir-125a Carcinoma, Hepatocellular miR-125a-5p-targeted regulation of TRA2β expression inhibits proliferation and metastasis of hepatocellular carcinoma cells. +target gene 35035706 hsa-mir-140 Breast Neoplasms Oxymatrine inhibits proliferation and apoptosis of human breast cancer cells through the regulation of miRNA-140-5P. +genetics_overexpression_promote 35035705 hsa-mir-200c Opitz GBBB Syndrome, X-Linked Taok1 overexpression could reverse the protective action of miR-200c-3p overexpression on the OS injury of HEI-OC1 cells. +lncRNA target 35035705 hsa-mir-200c Cochlear Diseases OBJECTIVE: The aim of this study was to elucidate the role of miR-200c-3p in cochlear hair cells injured by oxidative stress (OS) and the underlying mechanisms. CONCLUSIONS: Given the capacity of miR-200c-3p to suppress the OS and apoptosis of HEI-OC1 cells via targeting Taok1, it can be a novel and potential therapeutic target for cochlear hair cell injury. +genetics_overexpression_promote 35035684 hsa-mir-98 Nasopharyngeal Carcinoma 5p overexpression on the NPC cells (all P<0.05). +other 35035663 hsa-mir-193a Coronary Disease In addition, TBX1 and miR-193a-3p expression was significantly downregulated and TGF-beta2 levels were high in human embryonic CHD tissues, as indicated by the H9c2 cell experiments. In summary, the TBX1/miR-193a-3p/TGF-beta2 axis mediates CHD by inducing ferroptosis in cardiomyocytes. +transcription factor target 35035482 hsa-mir-223 Stomach Neoplasms In summary, our findings reveal that miR-223 increases tumor progression in GC by targeting RhoB, suggesting that it could serve to be a potential biomarker for the prediction of the disease. +transcription factor target 35034634 hsa-mir-194 Lung Neoplasms Sp1 inhibited CD44 expression by increasing the expression of miR +circulation_biomarker_diagnosis_up 35034594 hsa-mir-210 Lupus Erythematosus, Systemic CONCLUSION: The dysregulation of circulating miR-210/HIF-1alpha levels in SLE/ photosensitivity patients is controlled by the presence of additional pathological complications, and results suggest that the hypoxia pathway might interact positively with the pathogenesis and disease progression of SLE. +circRNA target 35034587 hsa-mir-145 Diabetic Cardiomyopathies Hence, circ_0071269 may promote the development of DCM through the miR-145/GSDMA axis and thus provide a novel marker for the treatment of DCM. +lncRNA target 35034584 hsa-mir-155 C syndrome albicans and significant improvement of histological damage by CGA-N12 through microRNA-155/SOCS1 axis were proved in this study. +genetics_overexpression_promote 35034572 hsa-mir-655 Carcinoma, Hepatocellular 3p overexpression inhibited HCC cell oncogenic phenotypes mentioned above, which were attenuated by ACER3 up-regulation. +lncRNA target 35034562 hsa-mir-23a Ovarian Failure, Premature In conclusion, TRERNA1 may sponge miR-23a to suppress granulosa cell apoptosis in POF. +lncRNA target 35034548 hsa-mir-200c Chronic Periodontitis Consequently, the silencing of NEAT1 inhibits inflammation and apoptosis via targeting miR-200c-3p/TRAF6 axis, thereby contributing to alleviate the progression of CP. +lncRNA target 35034547 hsa-mir-423 Colorectal Neoplasms Collectively, our results demonstrated that ATF3-activated FOXP4-AS1 aggravates CRC progression by regulating miR5p/NACC1 axis, indicating a new target for CRC treatment. +genetics_overexpression_suppress 35034539 hsa-mir-515 Colon Adenocarcinoma 5p overexpression reversed the inhibition of COAD cell proliferation and migration by UBXN10-AS1 overexpression, and SLIT3 overexpression counteracted the oncogenicity of miR +lncRNA target 35034538 hsa-mir-129 Cardiomegaly 5p targeted Smurf1 and repressed the ubiquitination of PTEN, and promoted PTEN expression, thus improving the cardiac function of CHF rats. +lncRNA target 35034519 hsa-mir-96 Carcinoma, Non-Small-Cell Lung Moreover, HOXC-AS3 suppressed the role of miR-96 in inhibiting NSCLC cell invasion and migration. +genetics_overexpression_promote 35034420 hsa-mir-203 Inflammation CONCLUSION: These experimental data demonstrated the potential inhibitory effects of overexpressed miR-203 on periodontitis development by promoting PDLC differentiation and suppressing inflammatory responses through AP-1/ICAM-1 axis. +genetics_knock down_promote 35034256 hsa-mir-150 Myopia Gain- and loss-of-function experiments were performed in hypoxia-exposed HSFs to evaluate the effect of the HIF-1alpha/miR +circRNA target 35034254 hsa-mir-636 Carcinoma, Non-Small-Cell Lung Circ_0025039 silencing repressed NSCLC malignant progression by reducing CORO1C expression through miR-636, showing the possibility of circ_0025039 as a therapeutic target for NSCLC. +genetics_knock down_promote 35034245 hsa-mir-619 Colorectal Neoplasms Circ-FAT1 knockdown repressed FOSL2 expression by sponging miR +circRNA target 35034206 hsa-mir-221 Stomach Neoplasms 3p were targets of circ_0003159, and the inhibition of miR +circRNA target 35034206 hsa-mir-222 Stomach Neoplasms 3p were targets of circ_0003159, and the inhibition of miR +lncRNA target 35033901 hsa-mir-802 Uterine Cervical Neoplasms Our study identified circ_0084904 as a novel oncogenic driver in CC depending on the modulation of the miR-802/MAL2 axis, establishing the notion that silencing of circ_0084904 might represent a promising targeted therapy for CC. +other 35033900 hsa-mir-21 Guillain-Barre Syndrome miR-21 significantly increased the secretion of IL-1 but decreased that of IL-10 in DSCs cells infected with GBS. +other 35033900 hsa-mir-21 Obstetric Labor, Premature miR-21 differentially regulates IL-1 and IL-10 expression in human decidual Intrauterine infections caused by bacteria like group B streptococcus (GBS) and the subsequent activation of the maternal inflammatory response have been long suspected to be the underlying cause of preterm labor. +other 35033900 hsa-mir-21 Reproductive Tract Infections miR-21 differentially regulates IL-1 and IL-10 expression in human decidual Intrauterine infections caused by bacteria like group B streptococcus (GBS) and the subsequent activation of the maternal inflammatory response have been long suspected to be the underlying cause of preterm labor. +genetics_overexpression_promote 35033353 hsa-mir-338 Neuroblastoma CONCLUSION: Overexpression of KLF5 reduced expression of miR-338, which in turn increased the expression of KIF1A and activated the Hedgehog signaling pathway, leading to the progression of NB. +lncRNA target 35033084 hsa-mir-937 Adenocarcinoma of Lung 3p can be used as a therapeutic target and potential biomarker for LUAD. +target gene 35033075 hsa-mir-375 Colorectal Neoplasms hsa_circ_0000231 Promotes colorectal cancer cell growth through upregulation of CCND2 by IGF2BP3/miR-375 dual pathway. +transcription factor target 35033060 hsa-mir-10b Glioblastoma CONCLUSIONS: We identified U6 snRNA, the key RNA component of the spliceosome, as the top miR-10b target in glioblastoma. +other 35033060 hsa-mir-10b high grade glioma Malignant gliomas exhibit particularly striking dependence on miR-10b. We provide evidence of the direct binding between miR-10b and U6, in situ imaging of miR-10b and U6 co-localization in glioma cells and tumors, and biochemical co-isolation of miR-10b with the components of the spliceosome. +lncRNA target 35033021 hsa-mir-22 Ischemic Stroke CONCLUSIONS: Our findings suggested that CDKN1A/JUN could be a robust and promising gene-pair diagnostic biomarker for IS, regulating ferroptosis during IS progression via C9orf106/C9orf139-miR +lncRNA target 35033021 hsa-mir-429 Ischemic Stroke CONCLUSIONS: Our findings suggested that CDKN1A/JUN could be a robust and promising gene-pair diagnostic biomarker for IS, regulating ferroptosis during IS progression via C9orf106/C9orf139-miR +transcription factor target 35032930 hsa-mir-424 Endometritis 5p inhibitors and siRNA-IRAK2 revealed that negative regulation of miR +transcription factor target 35032930 hsa-mir-424 Inflammation 5p inhibitors and siRNA-IRAK2 revealed that negative regulation of miR +other 35032791 hsa-mir-346 Pneumonia, Mycoplasma RESULTS: CircHIPK3 and KCMF1 were downregulated, while miR-346 was upregulated in placenta tissues from PE patients. +other 35032287 hsa-mir-140 Polycystic Ovary Syndrome 3p associated with the PI3K/Akt pathway were found to be up-regulated in granulosa cells of women with PCOS. +other 35032287 hsa-mir-20a Polycystic Ovary Syndrome 3p associated with the PI3K/Akt pathway were found to be up-regulated in granulosa cells of women with PCOS. +genetics_knock down_suppress 35032277 hsa-mir-496 Osteochondritis Dissecans Moreover, miR-496 inhibition or PDCD4 overexpression abolished the inhibitory effects of circ_0007290 knockdown OGD-evoked neuronal injury. Knockdown of circ_0007290 alleviated OGD-induced neuronal injury by regulating miR-496/PDCD4 axis, providing a novel insight into the pathology of ischemic stroke. +genetics_knock down_suppress 35032277 hsa-mir-496 Ischemic Stroke Knockdown of circ_0007290 alleviated OGD-induced neuronal injury by regulating miR-496/PDCD4 axis, providing a novel insight into the pathology of ischemic stroke. +exosome 35032276 hsa-mir-130a Glioma Circ_0037655 relieved SEV-induced glioma growth inhibition in vivo by mediating miR-130a-5p and RPN2 levels. +other 35032098 hsa-mir-6808 Liver Injury 5p were decreased. +other 35032098 hsa-mir-6874 Tuberculosis 5p were decreased. +other 35032098 hsa-mir-6874 Liver Injury 5p were decreased. +other 35032098 hsa-mir-3157 Liver Injury 5p were decreased. +other 35032098 hsa-mir-6808 Tuberculosis 5p were decreased. +other 35032098 hsa-mir-3157 Tuberculosis 5p were decreased. +lncRNA target 35031966 hsa-mir-590 Carcinoma, Non-Small-Cell Lung Moreover, increasing miR-590 suppressed Yes-associated protein 1 (YAP1) expression and inhibited the Wnt/beta-catenin pathway in NSCLC cells. +other 35031872 hsa-mir-374a Stomach Neoplasms 5p/hsa-miR-374a-5p/hsa-miR-429/hsa-mi These signatures vigorously characterized organo-tropic metastasis (all displaying AUC > 0.8, consistency >/= 75%), and effectively conjectured the risk of future metastasis within 5 years (accuracy 45.5% for occurrence, 70% for organotropism, P = 0.002 for prognostic diversity). +other 35031872 hsa-mir-186 Stomach Neoplasms 5p/hsa-miR-374a-5p/hsa-miR-429/hsa-mi These signatures vigorously characterized organo-tropic metastasis (all displaying AUC > 0.8, consistency >/= 75%), and effectively conjectured the risk of future metastasis within 5 years (accuracy 45.5% for occurrence, 70% for organotropism, P = 0.002 for prognostic diversity). +other 35031872 hsa-mir-200c Stomach Neoplasms 5p/hsa-miR-374a-5p/hsa-miR-429/hsa-mi These signatures vigorously characterized organo-tropic metastasis (all displaying AUC > 0.8, consistency >/= 75%), and effectively conjectured the risk of future metastasis within 5 years (accuracy 45.5% for occurrence, 70% for organotropism, P = 0.002 for prognostic diversity). +other 35031872 hsa-mir-429 Stomach Neoplasms 5p/hsa-miR-374a-5p/hsa-miR-429/hsa-mi These signatures vigorously characterized organo-tropic metastasis (all displaying AUC > 0.8, consistency >/= 75%), and effectively conjectured the risk of future metastasis within 5 years (accuracy 45.5% for occurrence, 70% for organotropism, P = 0.002 for prognostic diversity). +other 35031872 hsa-mir-24 Stomach Neoplasms 5p/hsa-miR-374a-5p/hsa-miR-429/hsa-mi These signatures vigorously characterized organo-tropic metastasis (all displaying AUC > 0.8, consistency >/= 75%), and effectively conjectured the risk of future metastasis within 5 years (accuracy 45.5% for occurrence, 70% for organotropism, P = 0.002 for prognostic diversity). +lncRNA target 35031788 hsa-mir-132 Urinary Bladder Neoplasms Furthermore, miR-132 downregulated the expression of NRF2 to restrict the viability and migratory ability of bladder cancer cells. +genetics_knock down_promote 35031054 hsa-mir-498 Urinary Bladder Neoplasms Circ_0000658 elevation or miR-498 knockdown augmented oncogenic phenotypes and EMT of BCa cells, corresponding to a reduction in the expression of beta-catenin and E-cadherin as well as an increase in the expression of N-cadherin, Slug, Snail, ZEB1 and Twist. +genetics_knock down_promote 35030981 hsa-mir-182 Stomach Neoplasms GC cell viability and autophagy were inhibited and apoptosis was promoted after circ_0001658 knockdown, and the cellular functions were reversed by downregulating miR-182. +circulation_biomarker_diagnosis_ns 35030978 hsa-mir-99b Prostatic Neoplasms MicroRNA-99b-5p (miR-99b-5p) has been shown to be enriched in serum exosomes of prostate cancer (PCa) patients treated with radiotherapy, while its function in PCa progression remains unclear. +lncRNA target 35030971 hsa-mir-942 Osteoporosis In conclusion, circ_0019693 promotes BMSC osteogenic differentiation osteogenesis-coupled angiogenesis via regulating miR5p-targeted PCP4, thus blocking the development of OP. +lncRNA target 35030969 hsa-mir-214 Prostatic Neoplasms Our study demonstrated the novel role of the SNHG3/miR3p/TGF-beta axis in tumor growth and bone metastasis in PC, indicating that SNHG3 may act as a biomarker and promising therapeutic target against PC. +lncRNA target 35030964 hsa-mir-761 Osteosarcoma Rescue experiments showed that low levels of miR-761 or restoration of IRS1 could neutralize the effects of ADIRF-AS1 ablation in OS cells. In summary, ADIRF-AS1 exacerbates the oncogenicity of the OS cells by targeting the miR-761/IRS1 axis. +lncRNA target 35030644 hsa-mir-217 Osteoporosis CONCLUSIONS: MALAT1 promotes osteogenic differentiation through regulating miR-217/AKT3 axis, suggesting that MALAT1 is a potential target with respect to alleviating osteoporosis. +genetics_knock down_suppress 35030455 hsa-mir-660 Multiple Myeloma 5p overexpression blocked the malignant phenotypes of MM cells by targeting CDK6. +circulation_biomarker_diagnosis_ns 35030371 hsa-mir-484 Multiple Sclerosis, Relapsing-Remitting Reverse Transcription-quantitative Real-Time PCR (RT-qPCR) was performed to detect the expression levels of APAF-1 and miR-484 in the peripheral blood mononuclear cells (PBMCs) of 34 RRMS patients recruited from the MS clinic of kasr al ainy hospital- faculty of medicine-Egypt and 34 healthy controls. +lncRNA target 35030351 hsa-mir-495 Carcinoma, Renal Cell Furthermore, MEG8 promoted G3BP1 expression to aggravate ccRCC tumorigenic properties through sponging miR +circulation_biomarker_diagnosis_ns 35030053 hsa-mir-24 Melanoma MATERIALS AND METHODS: The work was performed on cultured human melanoma Me45 cells, transiently transfected with plasmids containing Renilla luciferase reporter gene targeted by miRNAs Let-7, miR-21 or miR-24. +circulation_biomarker_diagnosis_ns 35030053 hsa-mir-21 Melanoma MATERIALS AND METHODS: The work was performed on cultured human melanoma Me45 cells, transiently transfected with plasmids containing Renilla luciferase reporter gene targeted by miRNAs Let-7, miR-21 or miR-24. +circulation_biomarker_diagnosis_ns 35029768 hsa-mir-21 Atrial Fibrillation The effects of non-PAF and levels of miRNA21 and IL-18 in left atrial serum on the recurrence of AF after cryoablation statistically differed (p < 0.05). CONCLUSION: The levels of miRNA21 and IL-18 were higher in left atrial blood than in peripheral blood, which may be related to the severity of AF and recurrence of AF after cryoablation. +lncRNA target 35029589 hsa-mir-542 Urinary Bladder Neoplasms CONCLUSIONS: Circ_0000515, as a tumor promoter, strengthens the viability, migration and aggressiveness of BC cells via modulating miR +genetics_overexpression_promote 35029520 hsa-mir-381 Stomach Neoplasms Further, FGFR2 overexpression partly reversed the miR +transcription factor target 35029026 hsa-mir-181a Triple Negative Breast Neoplasms In summary, autophagy inhibits cancer stemness through the miR-181a-regulated mechanism in TNBC. +other 35028969 hsa-mir-205 Nasopharyngeal Carcinoma 5p) may become a novel non-invasive biological marker for nasopharyngeal cancer screening. +other 35028969 hsa-mir-143 Nasopharyngeal Carcinoma 5p) may become a novel non-invasive biological marker for nasopharyngeal cancer screening. +other 35028969 hsa-mir-29c Nasopharyngeal Carcinoma 5p) may become a novel non-invasive biological marker for nasopharyngeal cancer screening. +circulation_biomarker_diagnosis_ns 35028969 hsa-mir-145 Nasopharyngeal Carcinoma RESULTS: In NPC patients, the expression of five serum miRNAs (miR-29c-3p, miR +circulation_biomarker_diagnosis_up 35028929 hsa-mir-100 Urinary Bladder Neoplasms 5p, in BC patients' serum were detected compared to NCs and were selected to establish the diagnostic panel. +circulation_biomarker_diagnosis_up 35028929 hsa-mir-143 Urinary Bladder Neoplasms 5p, in BC patients' serum were detected compared to NCs and were selected to establish the diagnostic panel. +circulation_biomarker_diagnosis_up 35028929 hsa-mir-182 Urinary Bladder Neoplasms 5p, in BC patients' serum were detected compared to NCs and were selected to establish the diagnostic panel. +circulation_biomarker_diagnosis_up 35028929 hsa-mir-125b Urinary Bladder Neoplasms 5p, in BC patients' serum were detected compared to NCs and were selected to establish the diagnostic panel. +circulation_biomarker_diagnosis_up 35028929 hsa-mir-200c Urinary Bladder Neoplasms 5p, in BC patients' serum were detected compared to NCs and were selected to establish the diagnostic panel. +circulation_biomarker_diagnosis_up 35028929 hsa-mir-1 Urinary Bladder Neoplasms 5p, in BC patients' serum were detected compared to NCs and were selected to establish the diagnostic panel. +circulation_biomarker_prognosis_down 35028121 hsa-mir-148a Carcinoma, Hepatocellular CONCLUSION: We demonstrated that serum exosomal miR-122 and miR-148a played a predictive role and were linked to prognosis in HCC via interactions with PAX2. +other 35028061 hsa-mir-29c Nasopharyngeal Carcinoma RESULTS: Hsa-miR-29c, hsa-miR-30e and hsa-miR-93 were selected from DEMs to construct a signature, and their abnormal expression was significantly associated with poor prognosis of NPC. +other 35028061 hsa-mir-93 Nasopharyngeal Carcinoma RESULTS: Hsa-miR-29c, hsa-miR-30e and hsa-miR-93 were selected from DEMs to construct a signature, and their abnormal expression was significantly associated with poor prognosis of NPC. +other 35027969 hsa-mir-126 psoriasis 1 Initial miR-126 levels in the buccal epithelium in children with psoriasis are a prognostic criterion for response to therapy and can be used as a marker for prescribing systemic treatment. +lncRNA target 35027936 hsa-mir-148a Intervertebral Disc Degeneration CONCLUSION: LncRNA HOTAIR promoted NP cell autophagy and apoptosis via promoting PTEN expression as a ceRNA of miR-148a in IDD. +target gene 35027933 hsa-mir-28 Lymphoma, Large B-Cell, Diffuse hsa-MicroRNA-28-5p Inhibits Diffuse Large B-Cell Lymphoma Cell Proliferation by Downregulating 14-3-3ζ Expression. +exosome 35027847 hsa-mir-216b Breast Neoplasms Hypoxic Breast Cancer Cell-Derived Exosomal SNHG1 Promotes Breast Cancer Growth and Angiogenesis via Regulating miR-216b-5p/JAK2 Axis. +lncRNA target 35027543 hsa-mir-135b Pancreatic Carcinoma Our results stressed that KLF4, as a vital target of miR-135b-5p, could influence promoter region of GPRC5A, thus affecting the malignant progression of pancreatic cancer. +circulation_biomarker_diagnosis_up 35027539 hsa-mir-637 Stomach Neoplasms Further mechanism investigation demonstrated that circRELL1 could sponge miR-637 and indirectly unregulated the expression of EPHB3 via modulating autophagy activation in GC. Taken together, this study elucidates the suppressive roles of circRELL1/miR-637/EPHB3 axis through autophagy activation in GC progression, inspiring for further understanding of the underlying molecular mechanisms of GC and providing a promising novel diagnostic circulating biomarker and therapeutic target in GC. +circRNA target 35027503 hsa-mir-208a Colorectal Neoplasms CONCLUSION: CircCUL2 participates in progression via the miR-208a-3p/PPP6C axis in colorectal cancer. +circulation_biomarker_diagnosis_ns 35027490 hsa-mir-21 Breast Neoplasms The Association between Plasma miRNA-21 Levels with Overall 1-year Survival Rate BACKGROUND: miRNA 21 exhibits an increased expression in breast cancer (BC). +genetics_overexpression_promote 35027053 hsa-mir-625 Ovarian Neoplasms, High-Grade Serous RESULTS: Overexpression of miR +other 35026963 hsa-mir-155 Sepsis This study aimed to analyze the expression pattern and to assess the diagnostic/prognostic value of miRNAs miR-21, miR-29a miR-31, miR-146a, and miR-155 in late-onset neonatal sepsis. +other 35026963 hsa-mir-29a Sepsis This study aimed to analyze the expression pattern and to assess the diagnostic/prognostic value of miRNAs miR-21, miR-29a miR-31, miR-146a, and miR-155 in late-onset neonatal sepsis. A receiver operating characteristic curve (ROC) analysis of miR-21 and miR-29a (0.829 and 0.787 AUC of ROC curves) showed good discrimination for the identification of sepsis from non-sepsis neonates. +other 35026963 hsa-mir-21 Sepsis This study aimed to analyze the expression pattern and to assess the diagnostic/prognostic value of miRNAs miR-21, miR-29a miR-31, miR-146a, and miR-155 in late-onset neonatal sepsis. A receiver operating characteristic curve (ROC) analysis of miR-21 and miR-29a (0.829 and 0.787 AUC of ROC curves) showed good discrimination for the identification of sepsis from non-sepsis neonates. +other 35026963 hsa-mir-1 Sepsis This study aimed to analyze the expression pattern and to assess the diagnostic/prognostic value of miRNAs miR-21, miR-29a miR-31, miR-146a, and miR-155 in late-onset neonatal sepsis. +other 35026963 hsa-mir-146a Sepsis This study aimed to analyze the expression pattern and to assess the diagnostic/prognostic value of miRNAs miR-21, miR-29a miR-31, miR-146a, and miR-155 in late-onset neonatal sepsis. +other 35026768 hsa-mir-129 Parkinson Disease 5p mediated the function of HOTAIR on cognition and oxidative balance in the ISO-managed SD rat model. +other 35026768 hsa-mir-129 Cognition Disorders 5p mediated the function of HOTAIR on cognition and oxidative balance in the ISO-managed SD rat model. +lncRNA target 35026645 hsa-mir-181c Triple Negative Breast Neoplasms This study is the first to demonstrate the miR-181c/MAP4K4 signaling in suppressing TNBC, providing a novel therapeutic target for TNBC. +other 35026632 hsa-mir-198 Hemoglobinuria, Paroxysmal The miRNA-198 has been reported a potential prognostic and early diagnostic marker signature of PC. +circulation_biomarker_diagnosis_ns 35026632 hsa-mir-198 Pancreatic Carcinoma More importantly, the proposed detection platform can be applied directly to distinguish the expression of miRNA-198 in clinical serum, affording the ability to distinguish pancreatic cancer patients from those of healthy human beings, and quantify the expression variation of miRNA-198 for the pancreatic cancer patients before and after resection, which may pave the way to develop novel clinical diagnostic equipment for cancer diagnosis and therapeutic evaluation. +target gene 35026514 hsa-mir-665 Stomach Neoplasms Paeonol inhibits the malignancy of Apatinib-resistant gastric cancer cells via LINC00665/miR-665/MAPK1 axis. +transcription factor target 35026295 hsa-mir-200a Glioma This study proved that EMT promotes the expression of TF in glioma cells through the miR-200a/ZEB1 axis. In summary, these results indicated that EMT can promote the expression of TF in glioma cells via the miR-200a/ZEB1 axis. +exosome 35026284 hsa-mir-29b Fractures, Bone Accordingly, the current study sought to determine the functions of microRNA (miR)-29b-3p from BM-MSCs-derived extracellular vesicles (EVs) on the angiogenesis of fracture healing via the PTEN/PI3K/AKT axis. +transcription factor target 35026214 hsa-mir-29a Uterine Cervical Neoplasms The role of miR-29a-3p was confirmed using Antago-miR-29a-3p, which reversed the Ang-A-inhibited expression of MMP2 and VEGFA, invasive motility, and angiogenesis in human cervical cancer cells. SIGNIFICANCE: These findings are the first to indicate that in human cervical cancer cells, Ang-A exerts anti-metastatic and anti-angiogenic effects via targeting the miR-29a-3p/MMP2/VEGFA axis, mediated through the ERK pathway. +other 35026193 hsa-mir-146a Drug Hypersensitivity Moreover, DAPA elevated expression levels of anti-inflammatory miR-146a, while values of miR-155 decreased in those cells. +other 35026193 hsa-mir-155 Drug Hypersensitivity Moreover, DAPA elevated expression levels of anti-inflammatory miR-146a, while values of miR-155 decreased in those cells. +genetics_knock down_promote 35025943 hsa-mir-27a Nervous System Diseases Among the altered micro-RNAs, miR-27a-3p was found to be downregulated in a number of neurological diseases characterized by loss of inter-endothelial junctions and disruption of the barrier integrity. Thus, miR-27a-3p may constitute a novel therapeutic target that could be exploited to prevent BBB dysfunction and preserves its integrity in neurological disorders characterized by impairment of the barrier's function. +circulation_biomarker_diagnosis_up 35025700 hsa-mir-19b Fibrosis, Renal HN rats were injected with miR-19b-3p- or HDAC3-related vectors to figure out their effects on RIF through detecting 24-h urine protein, uric acid (UA), blood urea nitrogen (BUN) and serum creatinine (Scr) contents and alpha-smooth muscle actin (alpha-SMA), transforming growth factor beta1 (TGF-beta1) and fibronectin (FN) contents in renal tissues and observing pathological damages and RIF index of renal tissues. +circulation_biomarker_diagnosis_up 35025700 hsa-mir-19b Hyperuricemia HN rats were injected with miR-19b-3p- or HDAC3-related vectors to figure out their effects on RIF through detecting 24-h urine protein, uric acid (UA), blood urea nitrogen (BUN) and serum creatinine (Scr) contents and alpha-smooth muscle actin (alpha-SMA), transforming growth factor beta1 (TGF-beta1) and fibronectin (FN) contents in renal tissues and observing pathological damages and RIF index of renal tissues. +genetics_knock down_promote 35025697 hsa-mir-124 Lung Neoplasms Loss or gain-of-function experiments of circPVT1 and miR +genetics_knock down_suppress 35025075 hsa-mir-25 Stroke * miR-25 inhibits loss of neurons and provides neuronal recovery in animal model of stroke via inhibiting HDAC3 and ATXN3. +other 35024240 hsa-mir-148a Alzheimer Disease In conclusion, the present study implicated the miR-148a-3p/p35/PTEN pathway as an essential contributor to tau hyperphosphorylation and feedforward regulation in AD. +target gene 35024096 hsa-mir-4759 Breast Neoplasms miR-4759 suppresses breast cancer through immune checkpoint blockade. +other 35023957 hsa-mir-195 Adenocarcinoma of Lung 3p expression is significantly associated with poor survival in LUAD, which may be a promising prognostic biomarker for LUAD. +other 35023789 hsa-mir-608 Gestational Trophoblastic Disease Although not reaching statistically significant, miR-608 expression was slightly lower in GTN moles compared to remission moles. +lncRNA target 35023690 hsa-mir-16 Osteoarthritis CONCLUSIONS: lncRNA SNHG12 regulates OA development by inhibiting miR +circulation_biomarker_prognosis_ns 35023689 hsa-mir-129 gastric cardia adenocarcinoma (2) The expression of miR-129 declined in the tissues and serum of GCA patients compared with that in HCs (p < 0.01). +lncRNA target 35023687 hsa-mir-124 Squamous Cell Carcinoma of Head and Neck Up-regulating miR-124 significantly inhibited TSCC cell migration and proliferation. +circRNA target 35023214 hsa-mir-149 Thyroid Neoplasms 5p to relieve the inhibition of miR +lncRNA target 35023068 hsa-mir-342 Breast Neoplasms 3p inhibitor transfection was conducted to further explore the miR +other 35023059 hsa-mir-144 Parkinson Disease In summary, we have identified a set of miRNAs (miR-144, miR-96, and miR-29a) and proteins (PLP1, TUBB4A, and TUBA1C), which can be used as a potential biomarker of PD, while further validation required large human population studies. +other 35023059 hsa-mir-29a Parkinson Disease In summary, we have identified a set of miRNAs (miR-144, miR-96, and miR-29a) and proteins (PLP1, TUBB4A, and TUBA1C), which can be used as a potential biomarker of PD, while further validation required large human population studies. +other 35023059 hsa-mir-96 Parkinson Disease In summary, we have identified a set of miRNAs (miR-144, miR-96, and miR-29a) and proteins (PLP1, TUBB4A, and TUBA1C), which can be used as a potential biomarker of PD, while further validation required large human population studies. +other 35023052 hsa-mir-139 Uterine Cervical Neoplasms Circ_0003221 downregulation restrains cervical cancer cell growth, metastasis, and angiogenesis by governing the miR3p/S100A14 pathway. +genetics_overexpression_promote 35023001 hsa-mir-3918 Glioma When overexpressed, EGFR can restore the inactivated PI3K/AKT and ERK pathways caused by miR-3918 and influence the glioma cell proliferation and migration. +genetics_GWAS 35022999 hsa-mir-361 Colorectal Neoplasms In conclusion, VPS9D1-AS1 gene rs7206570 polymorphism affecting hsa-miR +epigenetics 35022519 hsa-mir-375 Breast Neoplasms This study set out to elucidate the underlying mechanism by which lncRNA UCA1 affects the m(6)A modification of miR-375 by mediating the DNA methylation of METTL14 and then altering SOX12 expression in breast cancer. +lncRNA target 35022405 hsa-mir-646 Thyroid Cancer, Papillary Mechanistically, circTIAM1 acted as a sponge of microRNA-646 and functioned in PTC by targeting miR-646 and heterogeneous ribonucleoprotein A1. +circulation_biomarker_diagnosis_up 35022330 hsa-mir-376a Cholangiocarcinoma Simultaneously, PSMA3-AS1 primarily localized in the cytoplasm could competitively bind miR-376a-3p to upregulate LAMC1, thereby accelerating CCA progression. This study uncovers that PSMA3-AS1 functions as a cancer-promoting gene in CCA, and PAX5/PSMA3-AS1/miR-376a-3p/LAMC1 axis plays a vital role in CCA development. +genetics_overexpression_promote 35022277 hsa-mir-139 Influenza, Human Our study demonstrates that the development of naive T cells and generation or differentiation of effector or memory CD8(+) T cell responses to influenza virus infection are not impacted by miR-139 deficiency or overexpression; yet, miR-139(-/-) CD8(+) T cells are outcompeted by wild-type CD8(+) T cells in a competition setting and demonstrate reduced responses to Listeria monocytogenes Using an in vitro model of T cell exhaustion, we confirmed that miR-139 expression similarly does not impact the development of T cell exhaustion. +other 35022242 hsa-mir-408 Joint Dislocations We also found that the PCY-SAG14 module is repressed by a conserved microRNA, miR408, which in turn is repressed by phytochrome interacting factor 3/4/5 (PIF3/4/5), the key trio of transcription factors promoting DIS. +lncRNA target 35021946 hsa-mir-18a Nasal Polyps CONCLUSIONS: STAT1 acts as a transcription factor to promote transcription of miR-18a, and miR-18a targets PTEN to exacerbate the inflammatory response and EMT in CRSwNP. +other 35021944 hsa-mir-155 Behcet Syndrome Additional studies are warranted to suggest nanocurcumin as a safe complementary therapy in BD.HighlightsNanocurcumin supplementation decreased Th17 cells frequency significantly compared with baseline and placebo group.Nanocurcumin supplementation decreased mRNA expression of RORgammat, IL-17, IL-23, miRNA-155, miRNA-181, and miRNA-326 significantly compared to baseline and placebo group.Nanocurcumin supplementation decreased cell supernatant IL-17 and IL-23 significantly compared to baseline and placebo group.Nanocurcumin supplementation decreased disease activity significantly compared to placebo group. +other 35021944 hsa-mir-326 Behcet Syndrome Additional studies are warranted to suggest nanocurcumin as a safe complementary therapy in BD.HighlightsNanocurcumin supplementation decreased Th17 cells frequency significantly compared with baseline and placebo group.Nanocurcumin supplementation decreased mRNA expression of RORgammat, IL-17, IL-23, miRNA-155, miRNA-181, and miRNA-326 significantly compared to baseline and placebo group.Nanocurcumin supplementation decreased cell supernatant IL-17 and IL-23 significantly compared to baseline and placebo group.Nanocurcumin supplementation decreased disease activity significantly compared to placebo group. +other 35021944 hsa-mir-181 Behcet Syndrome Additional studies are warranted to suggest nanocurcumin as a safe complementary therapy in BD.HighlightsNanocurcumin supplementation decreased Th17 cells frequency significantly compared with baseline and placebo group.Nanocurcumin supplementation decreased mRNA expression of RORgammat, IL-17, IL-23, miRNA-155, miRNA-181, and miRNA-326 significantly compared to baseline and placebo group.Nanocurcumin supplementation decreased cell supernatant IL-17 and IL-23 significantly compared to baseline and placebo group.Nanocurcumin supplementation decreased disease activity significantly compared to placebo group. +lncRNA target 35021605 hsa-mir-29 Leukemia, Lymphocytic, Chronic, B-Cell Importantly, we found that B cells derived from CLL patients had higher expression levels of the miRNA-21 and miRNA-29, which suppresses PTEN translation, compared to healthy donors. +genetics_knock down_promote 35021067 hsa-mir-338 Brain Ischemia 3p knockdown attenuated ischemic injury and simultaneously reduced the microtubule-associated protein 1 light chain 3 (LC3)-II/LC3-I ratio, which contributes to neuronal survival after ischemia. +other 35020867 hsa-mir-155 Arthritis, Rheumatoid Together, these data underpin the notion that miRdriven myeloid cell activation in the synovium contributes not only to inflammation but may also influence the adaptive immune response. +lncRNA target 35020847 hsa-mir-155 Intervertebral Disc Degeneration Targeting MIR155HG could be a novel and promising strategy to slow down the progression of IDD. +other 35020440 hsa-mir-204 Graft vs Host Disease Blockade of miR-204 abolished the effects of MSC-exo, while overloading L929-exo with miR-204 markedly attenuated dry eye. Thus, this study suggests that MSC-exo are efficacious in treating GVHD-associated dry eye disease and highlights miR-204 as a potential therapeutic agent. +other 35020440 hsa-mir-204 Dry Eye Syndromes Blockade of miR-204 abolished the effects of MSC-exo, while overloading L929-exo with miR-204 markedly attenuated dry eye. Thus, this study suggests that MSC-exo are efficacious in treating GVHD-associated dry eye disease and highlights miR-204 as a potential therapeutic agent. +lncRNA target 35020000 hsa-mir-181c Inflammation CONCLUSION: Altogether, our data provide a novel function of miR-181c-5p in macrophage biology and suggest that targeting macrophage miR-181c-5p in injured tissues might improve clearance of dead cells and lead to efficient inflammation resolution. +target gene 35019376 hsa-mir-29b Liver Neoplasms LA-PLGA-Sil instigate the cell death of HepG2 cells via apoptosis by targeting the miR-29b/p53 axis through the stabilization of NFκB. +transcription factor target 35018773 hsa-mir-155 Myocardial Infarction Finally, the target miR-155 in urine samples collected from MI rats was quantified and the level of miR-155 in MI groups was 30 times higher than in the control groups. The results suggest that urinary miR-155 could be a novel biomarker for the noninvasive diagnosis of MI. +lncRNA target 35018772 hsa-mir-21 Lung Neoplasms In the presence of lung cancer-associated target miRNAs (miR-21, miR-141, and miR-125b), DNA walking machines were stimulated and operated to liberate a large number of lanthanide elements (Tb, Ho, and Tm), and then the signals were collected simultaneously by HR-ICPMS. +lncRNA target 35018772 hsa-mir-125b Lung Neoplasms In the presence of lung cancer-associated target miRNAs (miR-21, miR-141, and miR-125b), DNA walking machines were stimulated and operated to liberate a large number of lanthanide elements (Tb, Ho, and Tm), and then the signals were collected simultaneously by HR-ICPMS. +lncRNA target 35018772 hsa-mir-141 Lung Neoplasms In the presence of lung cancer-associated target miRNAs (miR-21, miR-141, and miR-125b), DNA walking machines were stimulated and operated to liberate a large number of lanthanide elements (Tb, Ho, and Tm), and then the signals were collected simultaneously by HR-ICPMS. +other 35018758 hsa-mir-6717 Pituitary ACTH Hypersecretion 5p 4.49 (p=0,031). +other 35018758 hsa-mir-383 Pituitary ACTH Hypersecretion 5p 4.49 (p=0,031). +other 35018758 hsa-mir-1203 Pituitary ACTH Hypersecretion 5p 4.49 (p=0,031). +other 35018758 hsa-mir-4290 Pituitary ACTH Hypersecretion 5p 4.49 (p=0,031). +lncRNA target 35018737 hsa-let-7b Obesity Conclusion: Hepatocyte TGF-beta-let-7b-5p signaling promotes HFD-induced steatosis and obesity by reducing mitochondrial oxidative phosphorylation and suppressing white-to-beige fat conversion. +lncRNA target 35018737 hsa-let-7b Non-alcoholic Fatty Liver Disease Conclusion: Hepatocyte TGF-beta-let-7b-5p signaling promotes HFD-induced steatosis and obesity by reducing mitochondrial oxidative phosphorylation and suppressing white-to-beige fat conversion. +genetics_overexpression_promote 35018247 hsa-mir-148a Stomach Neoplasms Overexpression of miR-148a in GC cells inhibited cell proliferation, migration, invasion and epithelial-mesenchymal transition. +circulation_biomarker_prognosis_up 35018114 hsa-mir-185 Ischemic Stroke CONCLUSION: There are two factors related to the up-regulated expression of serum miR-185 and miR-424, one is the severity degree of neurological impairment of patients with AIS and the other is their prognosis. +circulation_biomarker_prognosis_up 35018114 hsa-mir-424 Ischemic Stroke CONCLUSION: There are two factors related to the up-regulated expression of serum miR-185 and miR-424, one is the severity degree of neurological impairment of patients with AIS and the other is their prognosis. +transcription factor target 35017523 hsa-mir-365 Short Qt Syndrome Action potential recordings in patient-specific induced pluripotent stem cell-derived cardiac myocytes show that elevation of miR-365 significantly prolongs action potential duration in myocytes derived from a Short-QT syndrome patient, whereas specific inhibition of miR-365 normalizes pathologically prolonged action potential in Long-QT syndrome myocytes. +transcription factor target 35017523 hsa-mir-365 Short QT Syndrome 2 Action potential recordings in patient-specific induced pluripotent stem cell-derived cardiac myocytes show that elevation of miR-365 significantly prolongs action potential duration in myocytes derived from a Short-QT syndrome patient, whereas specific inhibition of miR-365 normalizes pathologically prolonged action potential in Long-QT syndrome myocytes. +lncRNA target 35017465 hsa-mir-326 Stomach Neoplasms Further mechanistic investigation showed that FAM225A acted as a miR-326 sponge to upregulate its direct target PADI2 in GC. Overall, our findings indicated that FAM225A promoted GC development and progression via a competitive endogenous RNA network of FAM225A/miR-326/PADI2 in GC, providing insight into possible therapeutic targets and prognosis of GC. +lncRNA target 35017437 hsa-mir-455 Reperfusion Injury, Cerebral Ischemia These results suggest that miR5p is a potential biomarker and therapeutic target for the treatment of cerebral ischemia/reperfusion injury and that it alleviates cerebral ischemia/reperfusion injury by inhibiting C-C chemokine receptor type 5 expression and reducing the neuroinflammatory response. +transcription factor target 35017014 hsa-mir-1 Hypertrophy Based on our results, we conclude that G3bp1 through its regulation of mature miR-1 levels plays a critical role in regulating the expression of essential cardiac-enriched genes and those involved in development of cardiomyocyte hypertrophy. +transcription factor target 35017014 hsa-mir-1 Cardiomegaly Based on our results, we conclude that G3bp1 through its regulation of mature miR-1 levels plays a critical role in regulating the expression of essential cardiac-enriched genes and those involved in development of cardiomyocyte hypertrophy. +other 35016888 hsa-mir-29a Myocardial Infarction CONCLUSION: Our study provides evidence that c-MYC binding to the promoter of miR-29a-3p to facilitate TET2 expression has therapeutic effect on ventricular remodeling of MI rats. +other 35016888 hsa-mir-29a Infarction Cardiac function, infarct size, cellular death, inflammatory response, oxidative stress, collagen deposition, c-MYC, TET2 and miR-29a-3p expression were analyzed. Up-regulating c-MYC or down-regulating miR-29a-3p in MI rat hearts improved cardiac function and reduced infarct size and myocardial apoptotic death, restrained oxidative stress, inflammatory response, attenuated collagen deposition. +lncRNA target 35016717 hsa-mir-423 Prostatic Neoplasms 5p, defined as a target with in silico prediction analysis, in PCa. +other 35016595 hsa-mir-130b Uterine Cervical Neoplasms CONCLUSION: miR-130b promoted the growth of cervical cancer cells during the exponential phase, whereas it impaired the survival of cells during stationary phases. +transcription factor target 35016493 hsa-mir-17 psoriasis 1 3p might be a novel therapeutic target for psoriasis. +circulation_biomarker_diagnosis_up 35016439 hsa-mir-21 Fibrosis, Atrial The increasing levels of circulating miR-21 were significantly associated with the higher risk of AF by using logistic regression analysis, even after adjustment for known confounding variables. +circulation_biomarker_diagnosis_up 35016439 hsa-mir-21 Atrial Fibrillation The increasing levels of circulating miR-21 were significantly associated with the higher risk of AF by using logistic regression analysis, even after adjustment for known confounding variables. +lncRNA target 35016264 hsa-mir-1270 Ovarian Neoplasms From rescue experiments, HCG11 impeded AKT/mTOR pathway to retard ovarian cancer cell growth by miR-1270/PTEN. CONCLUSIONS: HCG11 was a tumor suppressor in ovarian cancer cells and additionally, HCG11 regulated AKT/mTOR pathway to hinder ovarian cancer cell growth via modulating miR-1270/PTEN, indicating that HCG11 may represent a promising target for effective treatment of ovarian cancer patients. +exosome 35015859 hsa-mir-140 Subarachnoid Hemorrhage MSC-EV-delivered miR +exosome 35015859 hsa-mir-140 Brain Injuries MSC-EV-delivered miR +genetics_GWAS 35015850 hsa-mir-223 Friedreich Ataxia This study describes for the first time the association between hsa-miR223-3p and HAX-1 expression in FRDA, thus supporting a potential role of this microRNA as non-invasive epigenetic biomarker for FRDA. +lncRNA target 35015607 hsa-mir-423 Uterine Cervical Neoplasms 5p upregulation and LOXL1-AS1 downregulation inhibited CC cell proliferation and migration, while ENC1 upregulation attenuated the inhibitory effects of miR +lncRNA target 35015267 hsa-mir-1305 Carcinoma, Hepatocellular Overall, these results demonstrate that downregulation of circ_0008934 repress HCC growth and metastasis by upregulating miR-1305 to inhibit TMTC3, suggesting circ_0008934/ miR-1305/ TMTC3 regulatory axis may be a possible novel therapeutic target for HCC. +circulation_biomarker_diagnosis_ns 35015112 hsa-mir-133a Hyperglycemia CONCLUSIONS: The circulating miRNAs- miR-29a, miR-133a, miR-133b, and miR-155 are related to measures of glucose metabolism in healthy, normoglycemic men, but do not reflect peripheral insulin sensitivity or improvements in metabolic health following 8 weeks of combined exercise training. +circulation_biomarker_diagnosis_ns 35015112 hsa-mir-133b Hyperglycemia CONCLUSIONS: The circulating miRNAs- miR-29a, miR-133a, miR-133b, and miR-155 are related to measures of glucose metabolism in healthy, normoglycemic men, but do not reflect peripheral insulin sensitivity or improvements in metabolic health following 8 weeks of combined exercise training. +circulation_biomarker_diagnosis_ns 35015112 hsa-mir-29a Hyperglycemia CONCLUSIONS: The circulating miRNAs- miR-29a, miR-133a, miR-133b, and miR-155 are related to measures of glucose metabolism in healthy, normoglycemic men, but do not reflect peripheral insulin sensitivity or improvements in metabolic health following 8 weeks of combined exercise training. +circulation_biomarker_diagnosis_ns 35015112 hsa-mir-155 Hyperglycemia CONCLUSIONS: The circulating miRNAs- miR-29a, miR-133a, miR-133b, and miR-155 are related to measures of glucose metabolism in healthy, normoglycemic men, but do not reflect peripheral insulin sensitivity or improvements in metabolic health following 8 weeks of combined exercise training. +circulation_biomarker_diagnosis_ns 35015112 hsa-mir-29a Diabetes Mellitus, Type 2 Eight weeks of combined exercise training do not alter circulating microRNAs-29a, PURPOSE: Individuals with a family history of type 2 diabetes (FH+) have an increased risk of developing type 2 diabetes. +genetics_knock down_suppress 35014985 hsa-mir-374a Stroke Knockdown of NEAT1 regulated OGD/R injury of CHME5 cells via miR374a5p/NFAT5 axis to induce the shifting of microglia from M1 to M2 and inhibit inflammatory response, making it a potential target for stroke treatment. +genetics_overexpression_suppress 35014946 hsa-mir-195 Colorectal Neoplasms 5p overexpression model was engineered in CRC cells, followed by treatment with DDP or the autophagy inhibitor (Chloroquine, CQ). +genetics_knock down_suppress 35014684 hsa-mir-134 Breast Neoplasms Furthermore, the effect of a miR1343p inhibitor on BC progression was rescued by the knockdown of PITX2 in cells transfected with short hairpin RNAlncRNA PCAT1. +epigenetics 35014676 hsa-mir-181b Colorectal Neoplasms METTL3dependent m(6)A methylation promoted the miR181b5p process by DiGeorge Syndrome Critical Region 8 (DGCR8) in CAFs. +exosome 35014676 hsa-mir-181d Colorectal Neoplasms Furthermore, exosomal miR181d5p may represent a potential prognostic marker for CRC. +transcription factor target 35014672 hsa-mir-375 Hay-Wells syndrome However, the detailed mechanisms responsible for the effects of miR375 on Dexinduced AEC dysfunction remain elusive. Thus, it was suggested that the downregulated expression of miR375 may be a therapeutic target for AEC dysfunction. +other 35014431 hsa-mir-27a Breast Neoplasms Additionally, the remarkable discrimination of single nucleotide difference suggested superior selectivity and was able to detect miRNA-27a extracted from breast cancer cells. +transcription factor target 35014213 hsa-mir-671 Pulmonary Fibrosis Conclusion: We identify the negative regulation of miR5p on Angpt1 and VWF and liver fibrosis-associated angiogenesis, which may provide promising targets for the prevention and treatment of liver disease. +transcription factor target 35014213 hsa-mir-671 von Willebrand Diseases Conclusion: We identify the negative regulation of miR5p on Angpt1 and VWF and liver fibrosis-associated angiogenesis, which may provide promising targets for the prevention and treatment of liver disease. +other 35014077 hsa-mir-375 Breast Neoplasms Survival analysis of miR-34c-5p, miR-375, and miR3p showed a different impact on the prognosis of breast cancer patients. +other 35014077 hsa-mir-142 Breast Neoplasms Survival analysis of miR-34c-5p, miR-375, and miR3p showed a different impact on the prognosis of breast cancer patients. +other 35014077 hsa-mir-34c Breast Neoplasms Survival analysis of miR-34c-5p, miR-375, and miR3p showed a different impact on the prognosis of breast cancer patients. +other 35014054 hsa-mir-618 Heart Injuries PRACTICAL APPLICATIONS: The findings outlined in the current study show that the antifibrotic function of TAN is closely related to the function of miRs: the induction of miR-618 is indispensable for the function of TAN against the fibrotic process after heart injury, which will promote the application of TAN as an adjuvant therapy for improving heart function. +transcription factor target 35014054 hsa-mir-618 Hypertrophy TAN inhibits hypertrophy and collagen deposition in heart tissues, which is associated with the increased level of miR-618. +lncRNA target 35013925 hsa-mir-497 Pulmonary Fibrosis 5p-mediated suppression of CCL19 relieved HG-induced cell apoptosis, inflammation, and fibrosis in HK-2 cells. +lncRNA target 35013925 hsa-mir-497 Inflammation 5p-mediated suppression of CCL19 relieved HG-induced cell apoptosis, inflammation, and fibrosis in HK-2 cells. +transcription factor target 35013887 hsa-mir-200c Nervous System Diseases MiR-200c-3p/RIP2 might be a potential therapeutic target for the treatment of neuroinflammation-associated diseases. +lncRNA target 35013864 hsa-mir-142 Carcinoma, Hepatocellular Our findings suggest that MELK/miR5p axis could be a potentially therapeutic target for reversing the sorafenib resistance in HCC treatment. +genetics_knock down_promote 35013754 hsa-mir-766 Carcinoma, Non-Small-Cell Lung 5p interacted with the 3' untranslated region (3'UTR) of FAM83A, and FAM83A overexpression largely reversed miR +circulation_biomarker_diagnosis_ns 35013528 hsa-mir-5739 Glioblastoma CfmiR3p and cfmiR-5739 have potential utility in diagnosing patients with pGBM and rGBM tumors using a minimally invasive blood assay. +circulation_biomarker_diagnosis_ns 35013528 hsa-mir-3180 Glioblastoma CfmiR3p and cfmiR-5739 have potential utility in diagnosing patients with pGBM and rGBM tumors using a minimally invasive blood assay. +circulation_biomarker_diagnosis_ns 35013491 hsa-mir-92a Hypertension Serum miR-92a level was higher in hypertensive patients than controls. +lncRNA target 35013157 hsa-mir-432 Glioma In conclusion, circFOXM1 acts as a sponge of miR-432 to promote the proliferation and aggressiveness of glioma cells through the Galpha12 signalling pathway. +lncRNA target 35013144 hsa-mir-124 Carcinoma, Hepatocellular 3p.1-FOXO3a axis is implicated as a potential target for the diagnosis and treatment of HCC. +circulation_biomarker_diagnosis_down 35013132 hsa-mir-26a Stomach Neoplasms The level of miR-26a had negatively correlated with LINC00205 expression and was decreased among GC cell lines, tissues, and serum samples. +genetics_overexpression_suppress 35013115 hsa-mir-142 Nasopharyngeal Carcinoma 5p mimic-transfected NPC cells, followed by overexpression of HGF and EGF. +exosome 35013102 hsa-mir-499b Carcinoma, Hepatocellular These results indicate that exosome circRNAs secreted from RBPJ(+/+) Mphi inhibits tumor progression through the hsa_circ_0004658/miR-499b-5p/JAM3 pathway and hsa_circ_0004658 may be a diagnostic biomarker and potential target for HCC therapy. +circulation_biomarker_prognosis_up 35012923 hsa-mir-3682 Carcinoma, Hepatocellular 3p expression in the cytoplasm of HCC and adjacent tissues, and its expression was signifcantly up-regulated in HCC tissues (t=2.659, P=0.009). +circulation_biomarker_diagnosis_up 35012615 hsa-mir-3150b Uterine Cervical Neoplasms The cytoplasmic localization of LINC00885 was ascertained and furthermore, LINC00885 competitively bound with miR-3150b-3p to upregulate BAZ2A expression in CC cells. +genetics_knock down_promote 35012554 hsa-mir-7 Leukemia, Myeloid, Acute 5p, as well as in vitro and in vivo functional validation via gain- and loss-of-function methods. +genetics_knock down_promote 35012553 hsa-mir-326 Adenocarcinoma of Lung MiR-326 was a target of circ_0020850, and knockdown of miR-326 abolished the suppression effect of circ_0020850 on the malignant behaviors of lung adenocarcinoma cells. +target gene 35012539 hsa-mir-133a Ovarian Neoplasms miR-133a targets YES1 to reduce cisplatin resistance in ovarian cancer by regulating cell autophagy. +genetics_overexpression_promote 35012518 hsa-mir-342 Nasopharyngeal Carcinoma 3p overexpression attenuated the effect of TP73-AS1 in NPC cells. +lncRNA target 35012442 hsa-mir-144 Brain Ischemia Inhibition of lncRNA ZFAS1 improves functional recovery and angiogenesis after FCI via miR +lncRNA target 35012438 hsa-mir-137 Stomach Neoplasms These findings disclosed that PURPL serves as an oncogene in the context of GC via miR +lncRNA target 35012431 hsa-mir-1224 Laryngeal Papilloma Lnc-NEAT1 played a carcinogenic role in LP through mediating miR-577 or miR +lncRNA target 35012431 hsa-mir-577 Laryngeal Papilloma Lnc-NEAT1 played a carcinogenic role in LP through mediating miR-577 or miR +genetics_knock down_suppress 35012421 hsa-mir-181a Lissencephaly Rescue experiments showed that miR-181a-5p overexpression or ERG knockdown could reverse the inhibitory effects of circ_0020093 overexpression on the pathological changes in IL-1beta-induced C28/I2 cells. Circ_0020093 overexpression alleviated IL-1beta-induced human chondrocyte inflammatory injury, apoptosis and ECM degradation by targeting miR-181a-5p/ERG pathway. +other 35011745 hsa-mir-191 Myocardial Infarction 5p) showed different release behavior; hence, combining cTnT with these microRNAs within a multi-marker strategy may add diagnostic accuracy in MI. +other 35011745 hsa-mir-26a Myocardial Infarction 5p) showed different release behavior; hence, combining cTnT with these microRNAs within a multi-marker strategy may add diagnostic accuracy in MI. +other 35011745 hsa-mir-134 Myocardial Infarction 5p) showed different release behavior; hence, combining cTnT with these microRNAs within a multi-marker strategy may add diagnostic accuracy in MI. +lncRNA target 35011699 hsa-mir-155 Alzheimer Disease Candidate downregulated target genes by cortical miR-155 included Foxo3, Runx2 and CEBPbeta at 3 months and Foxo3, Runx2 and Socs1 at 9 months, which are implicated in cell survival, but also in Abeta pathology and microglia/astrocyte dysfunction. +other 35011660 hsa-mir-613 Coronary Artery Disease 3p. +other 35011660 hsa-mir-200a Coronary Artery Disease 3p. +lncRNA target 35011620 hsa-mir-511 Colitis Together, this study shows that miR-511 is involved in the regulation of intestinal inflammation through downstream regulation of TLR3 and TLR4 responses via Wdfy1. +other 35011587 hsa-mir-200a Adenocarcinoma of Lung The analysis of the multi-gene regulation model indicated that the WT1-AS (downregulation)-miR-200a-3p (upregulation)-IGF2BP2 (downregulation) pattern significantly improved the survival of LUAD patients. +transcription factor target 35011574 hsa-mir-140 Breast Neoplasms Collectively, the above results demonstrate the importance of the Nrf2/HO-1 axis in cancer progression and, thus, targeting Nrf2 by miR5p could be a better strategy for the treatment of Nrf2-driven breast cancer progression. +other 35008894 hsa-mir-938 Stomach Neoplasms Additionally, rs1553867776:T>TCCCCA (miR-4274) and rs12416605:C>T (miR-938) were associated with intestinal-type GC, and rs4822739:C>G (miR-548j) and rs1439619:T>G (miR-3175) with TNM I-II stage. +other 35008894 hsa-mir-3175 Stomach Neoplasms Additionally, rs1553867776:T>TCCCCA (miR-4274) and rs12416605:C>T (miR-938) were associated with intestinal-type GC, and rs4822739:C>G (miR-548j) and rs1439619:T>G (miR-3175) with TNM I-II stage. +other 35008894 hsa-mir-548j Stomach Neoplasms Additionally, rs1553867776:T>TCCCCA (miR-4274) and rs12416605:C>T (miR-938) were associated with intestinal-type GC, and rs4822739:C>G (miR-548j) and rs1439619:T>G (miR-3175) with TNM I-II stage. +other 35008894 hsa-mir-4274 Stomach Neoplasms Additionally, rs1553867776:T>TCCCCA (miR-4274) and rs12416605:C>T (miR-938) were associated with intestinal-type GC, and rs4822739:C>G (miR-548j) and rs1439619:T>G (miR-3175) with TNM I-II stage. +lncRNA target 35008854 hsa-mir-29a Diabetes Mellitus, Type 2 Thus, inhibition of miR-29a and or augmentation of ADAM12 improves experimental PAD outcomes in DM2 likely through modulation of Tie 2 and AKT signalling. +lncRNA target 35008854 hsa-mir-29a Peripheral Arterial Disease Thus, inhibition of miR-29a and or augmentation of ADAM12 improves experimental PAD outcomes in DM2 likely through modulation of Tie 2 and AKT signalling. +genetics_GWAS 35008806 hsa-mir-423 Breast Neoplasms We propose that the rs6505162-A allele promotes miR-423 overexpression, and that the rs6505162-A allele induces BC cell proliferation, viability, chemoresistance, migration, and invasion, and decreases cell apoptosis as a consequence. +other 35008751 hsa-mir-194 Breast Neoplasms 5p functions as a tumor biomarker in breast cancer, providing new insights for the study of breast cancer development and metastasis. +other 35008652 hsa-mir-494 Colorectal Neoplasms Analysis of human colorectal cancer tissue revealed that miR-494 was present at low levels in non-metastatic cases and cases with simultaneous liver metastases but was expressed at high levels in cases with delayed liver metastases, which also exhibited reduced expression of PGC1alpha and MYCC. +circulation_biomarker_prognosis_ns 35008626 hsa-mir-150 Lymphoma, Non-Hodgkin 5p/MALAT1 and hsa-miR335-5p/NEAT1 pairs' plasma levels were remarkably associated with NHL patients' prognosis, being independent prognostic factors in a multivariate Cox analysis. +circulation_biomarker_prognosis_ns 35008626 hsa-mir-335 Lymphoma, Non-Hodgkin 5p/MALAT1 and hsa-miR335-5p/NEAT1 pairs' plasma levels were remarkably associated with NHL patients' prognosis, being independent prognostic factors in a multivariate Cox analysis. +circulation_biomarker_diagnosis_down 35008579 hsa-mir-199a Graves Disease Interestingly, GD thyroids, GD plasmas and GO orbital fats showed a downregulation of miR-199a-3p/-5p. +other 35008529 hsa-mir-205 Carcinoma, Ductal, Breast CONCLUSIONS: miR5p and potentially ZEB1 gene are promising candidates for markers of metastatic potential in ductal BC. +lncRNA target 35008480 hsa-mir-630 Carcinoma, Embryonal Experimentally, we showed that transfection of MIR630 mimic into embryonal carcinoma cell lines directly targeted the 3'UTR of OCT4, SOX2, and NANOG and markedly suppressed their expression. +lncRNA target 35008442 hsa-mir-216a nonpapillary renal cell carcinoma Taken together, these results provide the first evidence that lucanthone enhances TRAIL-induced apoptosis through DR5 upregulation by downregulation of miR-216a-5p and DUB3-dependent Mcl-1 downregulation in human renal carcinoma cells. +circulation_biomarker_diagnosis_ns 35008424 hsa-mir-182 Carcinoma, Non-Small-Cell Lung Therefore, miR-3182 provides potential to be used for the detection of NSCLC in blood samples, which could result in earlier therapy and thus improved outcomes and survival for patients. +other 35008302 hsa-let-7 Medulloblastoma Altogether, our results suggest that let-7 activity and MYCN can further categorize heterogeneous SHH tumors into more and less-favorable prognostic subtypes, which provide critical information for personalizing treatment options for SHH-MB. +tissue_expression_up 35007926 hsa-mir-187 Abortion, Habitual We found that the expression of miR-187 in villi of RM group was higher than that of normal abortion group and miR-187 inhibited the proliferation, migration, and invasion of HTR8 cells. +therapeutic target 35007850 hsa-mir-365 Stomach Neoplasms Furthermore, Metformin and miR-365 synergistically promote the apoptosis of gastric cancer cells by miR-365-PTEN-AMPK axis. +target gene 35007826 hsa-mir-139 Osteosarcoma We found that the expression of miR-139 in osteosarcoma tissue was significantly reduced, while the expression of ITGAV was significantly increased. MiR-139 could specifically bind to the 3'-UTR of ITGAV and negatively regulate its expression. +lncRNA target 35007433 hsa-mir-17 Urinary Bladder Neoplasms 5p was shown to be a direct target of HAND2-AS1, and it reversed the inhibitory effect of HAND2-AS1 on BC malignancies. +exosome 35006577 hsa-mir-148a Liver Cirrhosis Bioinformatics analysis revealed miR-148a-5p as a regulator in liver fibrosis. Extracellular vesicles from miR-148a-5p enriched BMSCs attenuated hepatic fibrosis in liver fibrosis by targeting Smad4. +genetics_knock down_suppress 35006556 hsa-mir-142 Sleep Apnea, Obstructive 3p alleviated damage induced by MALAT1 knockdown in IH-treated HUVECs. +other 35005988 hsa-mir-218 Urinary Bladder Neoplasms 5p-CCNE2/SMC4 signal axis may be involved in the invasion process of bladder cancer. +transcription factor target 35005951 hsa-mir-122 Radiation Injuries It was demonstrated that the drug-induced hepatic inflammation could also be assessed via detecting miR-122 using this SERS method. +transcription factor target 35005951 hsa-mir-122 Hepatitis It was demonstrated that the drug-induced hepatic inflammation could also be assessed via detecting miR-122 using this SERS method. +tissue_expression_up 35005835 hsa-mir-214 Rhinitis, Allergic We found that miR-214-3p was overexpressed in macrophages and nasal mucus tissues from AR patients. +circulation_biomarker_diagnosis_down 35005769 hsa-mir-24 acute myocardial infarction We demonstrated that in acute myocardial infarction (AMI) patient blood samples, the expression of miR-24-3p is down-regulated, the expression of IL-1beta or NKAP is up-regulated, and IL-1beta or NKAP is negatively correlated with miR-24-3p. +other 35005549 hsa-mir-29c Osteoporosis ROC analysis shows miR-29cb2 in PB has higher sensitivity and specificity for diagnosing osteoporosis when compared with four clinical biomarkers. +other 35005241 hsa-mir-143 Instent Restenosis The purpose of this study is to observe the potential value and underlying mechanism of the metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)/miR-143 axis in ISR. MALAT1 is highly expressed in patients with ISR while miR-143 is decreased, and the MALAT1/miR-143 axis is a potential pathway to modulate the multiplication and invasiveness of HVSMCs. +circulation_biomarker_diagnosis_ns 35005155 hsa-mir-200c Ovarian Neoplasms, High-Grade Serous Transcriptomic analysis of patient plasma reveals circulating miR200c as a BACKGROUND: High-grade serous tubo-ovarian cancer (HGSC) is the most common histological subtype of epithelial ovarian cancer, and highly lethal. Further larger cohort studies exploring earlier stages are needed to determine whether circulating miR200c may be a sensitive and specific biomarker of tubo-ovarian cancer. +lncRNA target 35005034 hsa-mir-4679 Colorectal Neoplasms We then found that hsa-miR-4679 could bind to lncRNA CCAT1 directly, and with further functional analyses, we confirmed that lncRNA CCAT1 sponged hsa-miR-4679 to promote the progression of colorectal cancer. +lncRNA target 35005012 hsa-mir-10b Carcinoma, Hepatocellular CONCLUSIONS: miR-10b-5p reduced HCC cell proliferation but accelerate apoptosis by regulating EphA2, suggesting it has the potential to be a clinical target for HCC. +other 35004677 hsa-mir-20a Carcinoma, Renal Cell Collectively, HIF-1alpha mediated HECTD2 up-regulation and aggravated RCC progression by attenuating miR-320a. +other 35004351 hsa-mir-25 Rabies Another 4-miRNA signatures in exosomes (miR-25-3p, miR-26b-5p, miR-218-5p, miR-598-3p) can independently predict lyssavirus infected cells with >99% accuracy. +other 35004351 hsa-mir-218 Rabies Another 4-miRNA signatures in exosomes (miR-25-3p, miR-26b-5p, miR-218-5p, miR-598-3p) can independently predict lyssavirus infected cells with >99% accuracy. +other 35004351 hsa-mir-598 Rabies Another 4-miRNA signatures in exosomes (miR-25-3p, miR-26b-5p, miR-218-5p, miR-598-3p) can independently predict lyssavirus infected cells with >99% accuracy. +other 35004351 hsa-mir-26b Rabies Another 4-miRNA signatures in exosomes (miR-25-3p, miR-26b-5p, miR-218-5p, miR-598-3p) can independently predict lyssavirus infected cells with >99% accuracy. +other 35004326 hsa-mir-877 Glioblastoma Our results collectively indicate that circPIK3C2A functions as ceRNA by mediating miR5p/FOXM1 axis, providing a novel perspective of applying CircPIK3C2A in the clinical intervention of glioblastoma in the future. +other 35004298 hsa-mir-34c Triple Negative Breast Neoplasms Moreover, we found METTL3 is repressed by miR-34c-3p in TNBC cells. +lncRNA target 35004274 hsa-mir-429 Carcinoma, Ovarian Epithelial In conclusion, our study validated that EPDR1, negatively regulated by miR-429, played an important role as a tumor-suppressor gene in EOC development via inhibition of the PI3K/AKT pathway. The miR-429/EPDR1 axis might provide novel therapeutic targets for individualized treatment of EOC patients in the future. +target gene 35004266 hsa-mir-526b Breast Neoplasms MiR-526b-3p Attenuates Breast Cancer Stem Cell Properties and Chemoresistance by Targeting HIF-2α/Notch Signaling. +transcription factor target 35004265 hsa-mir-148b Carcinoma, Hepatocellular DTYMK is a key regulator of HCC progression, and its expression is suppressed by miR-148b-3p, suggesting that this miR-148b-3p/DTYMK regulatory axis may be amenable to therapeutic targeting in patients with HCC. +lncRNA target 35004257 hsa-mir-940 Adenocarcinoma of Lung CONCLUSIONS: The present study showed that miR-940 might be a protective factor for positive prognosis in early stage nonsmoking female lung adenocarcinoma, with transforming growth factor-beta (TGF-beta) pathway, TNF pathway, and matrix metalloprotein (MMP9) being potential targets. +target gene 35004133 hsa-mir-137 Non-alcoholic Fatty Liver Disease Mechanistically, we revealed that miR-137-3p is directly bound to the 3'-untranslated region of PDE4D and subsequently increased hepatic cAMP level and protein kinase A activity, thereby activating the downstream AMPKalpha pathway. +other 35003737 hsa-mir-186 Colorectal Neoplasms The aim of the present retrospective study was to identify the expression levels of miR-31, miR-145, miR-146b and miR-186 to highlight their role in CRC diagnosis and progression at different stages of the disease (precancerous polyp, adenoma and adenocarcinoma) in a Lebanese population. +other 35003737 hsa-mir-1 Colorectal Neoplasms The aim of the present retrospective study was to identify the expression levels of miR-31, miR-145, miR-146b and miR-186 to highlight their role in CRC diagnosis and progression at different stages of the disease (precancerous polyp, adenoma and adenocarcinoma) in a Lebanese population. These data suggested that miR-31 and miR-145, upon further clinical validation, may be used as potential diagnostic biomarkers for the early detection of CRC at the polyp stage. +other 35003737 hsa-mir-145 Colorectal Neoplasms The aim of the present retrospective study was to identify the expression levels of miR-31, miR-145, miR-146b and miR-186 to highlight their role in CRC diagnosis and progression at different stages of the disease (precancerous polyp, adenoma and adenocarcinoma) in a Lebanese population. These data suggested that miR-31 and miR-145, upon further clinical validation, may be used as potential diagnostic biomarkers for the early detection of CRC at the polyp stage. +other 35003737 hsa-mir-146b Colorectal Neoplasms The aim of the present retrospective study was to identify the expression levels of miR-31, miR-145, miR-146b and miR-186 to highlight their role in CRC diagnosis and progression at different stages of the disease (precancerous polyp, adenoma and adenocarcinoma) in a Lebanese population. +genetics_overexpression_promote 35003396 hsa-mir-372 Esophageal Neoplasms Functionally, overexpression of ADAM23 and ARHGEF26-AS1 and the miR3p inhibitor not only promoted ferroptosis in ESCC cells in vitro but also inhibited the proliferation and migration of cells. +genetics_overexpression_promote 35003396 hsa-mir-372 Thyroid Cancer, Papillary Functionally, overexpression of ADAM23 and ARHGEF26-AS1 and the miR3p inhibitor not only promoted ferroptosis in ESCC cells in vitro but also inhibited the proliferation and migration of cells. +genetics_knock down_suppress 35003317 hsa-mir-603 skin melanoma The results of the rescue experiment demonstrated that inhibiting microRNA-603 expression could suppress the proliferation, migration, and invasion of cutaneous melanoma cells, but its suppressive effect could be restored by TBX5. +lncRNA target 35003309 hsa-mir-15 Carcinoma, Non-Small-Cell Lung 5p expression in NSCLC cells and that NKD1, AXIN2, and WIF1 are the target genes of miR +lncRNA target 35003259 hsa-mir-370 Prostatic Neoplasms 3p could target P21(CIP1) in PCa cells. +genetics_overexpression_promote 35003111 hsa-mir-511 Arteritis Notably, we revealed miR-132-3p/-142-3p/-142-5p/-155-5p/-212-3p/-511-5p as major promoters of arterial inflammation and miR-30a-5p/-30c-5p/-30d-5p as putative regulators of NFATC signaling in TAB-positive GCA arteries. +genetics_overexpression_promote 35003111 hsa-mir-142 Arteritis Notably, we revealed miR-132-3p/-142-3p/-142-5p/-155-5p/-212-3p/-511-5p as major promoters of arterial inflammation and miR-30a-5p/-30c-5p/-30d-5p as putative regulators of NFATC signaling in TAB-positive GCA arteries. +genetics_overexpression_promote 35003111 hsa-mir-155 Arteritis Notably, we revealed miR-132-3p/-142-3p/-142-5p/-155-5p/-212-3p/-511-5p as major promoters of arterial inflammation and miR-30a-5p/-30c-5p/-30d-5p as putative regulators of NFATC signaling in TAB-positive GCA arteries. +genetics_overexpression_promote 35003111 hsa-mir-132 Arteritis Notably, we revealed miR-132-3p/-142-3p/-142-5p/-155-5p/-212-3p/-511-5p as major promoters of arterial inflammation and miR-30a-5p/-30c-5p/-30d-5p as putative regulators of NFATC signaling in TAB-positive GCA arteries. +genetics_overexpression_promote 35003111 hsa-mir-212 Arteritis Notably, we revealed miR-132-3p/-142-3p/-142-5p/-155-5p/-212-3p/-511-5p as major promoters of arterial inflammation and miR-30a-5p/-30c-5p/-30d-5p as putative regulators of NFATC signaling in TAB-positive GCA arteries. +tissue_expression_down 35002969 hsa-let-7e Muscular Atrophy The serum let-7e-5p levels were significantly lower, which might be in compensation, in subjects with decreased muscle mass compared to subjects without decreased muscle mass. +lncRNA target 35002727 hsa-mir-4640 Thyroid Cancer, Papillary Our findings confirmed for the first time that AhR antagonists promote differentiation of PTC via inhibiting the circSH2B3/miR5p/IGF2BP2 axis, offering a novel therapeutic approach and a potential marker for differentiation of PTC. +circRNA target 35002529 hsa-mir-938 Glioma An evaluation of the underlying mechanism revealed that circCDK14 sponged miR-3938 to upregulate oncogenic gene PDGFRA expression. +tissue_expression_up 35002516 hsa-mir-125a Pulmonary Disease, Chronic Obstructive beta-Galactose staining showed that the lung tissues of smokers have a higher degree of cellular senescence, and the expression of miR-125a-5p is high. +tissue_expression_up 35002514 hsa-mir-106b Carcinoma, Hepatocellular The expression of circCCNB1 and GPM6A were significantly down-regulated in HCC cells and cancer tissues, while miR-106b-5p expression was up-regulated. +genetics_knock down_promote 35002378 hsa-mir-23a Femur Head Necrosis In addition, icariin treatment/miR-23a knockdown increased bone biochemical markers (ACP-5, BAP, NTXI, CTXI and OC) and improved ONFH in ONFH model rats. +genetics_knock down_suppress 35002322 hsa-mir-636 Nasopharyngeal Carcinoma miR-636 overexpression or TPD52 knockdown weakened the promoting effect of Hsa_circ_0007637 on NPC cells malignant phenotype (P < 0.01). +other 35002277 hsa-mir-378a Inflammatory Bowel Diseases CONCLUSION: Two miRNAs (hsa-miR5p and hsa-miR-378a-5p) and three genes (ARNTL2, CLDN1, and SLC6A14) associated with the differential manifestations of UC in Uyghur and Han population were identified, which were potential biomarkers. +other 35002277 hsa-mir-141 Inflammatory Bowel Diseases CONCLUSION: Two miRNAs (hsa-miR5p and hsa-miR-378a-5p) and three genes (ARNTL2, CLDN1, and SLC6A14) associated with the differential manifestations of UC in Uyghur and Han population were identified, which were potential biomarkers. +genetics_overexpression_suppress 35001875 hsa-mir-145 Carcinoma, Non-Small-Cell Lung Overexpression of miR-145 decreased cell proliferation, induced apoptosis, and suppressed migration and invasion in lung cancer. Additionally, miR-145 co-transfection abolished the oncogenic role of hsa_circ_0003288. +circRNA target 35001739 hsa-mir-335 Lymphoma, Large B-Cell, Diffuse MiR-335-5p could be sponged by circ_0003645, and NFIB was confirmed to be a downstream target of miR-335-5p. +tissue_expression_up 35001683 hsa-mir-451a Pancreatic Neoplasms The expression of miR-451a in serum-derived exosomes from pancreatic cancer patients was significantly upregulated compared with those from PB patients and healthy individuals. +genetics_knock down_suppress 35001328 hsa-mir-23a Cerebral Infarction However, the improvement of BMSCs-exo to CI was reversed by miR-23a-3p knockdown. +target gene 35000595 hsa-mir-526b Carcinoma, Non-Small-Cell Lung we verified that OSBPL5 was a downstream target of miR-526b-3p and long noncoding RNA (lncRNA) LMCD1-AS1 served as a sponge for miR-526b-3p. +target gene 35000531 hsa-mir-128 Stomach Neoplasms All over these results showed lncRNA CCL2 played importance of role in gastric tumor via miR-128/PARP2 axis signal pathway. +circRNA target 35000524 hsa-mir-203 Urinary Bladder Neck Obstruction The circPVT1 and suppressor of cytokine signaling 3 (SOCS3) expression levels were upregulated (p = 0.0061 and 0.0328, respectively), whereas the microRNA-203a (miR-203) level was downregulated in rats with bladder remodeling (p=0.0085). +genetics_overexpression_suppress 35000421 hsa-mir-150 Heart Failure Importantly, miR-150 overexpression attenuates the detrimental post-MI effects caused by MIAT. +other 35000391 hsa-let-7a Lung Neoplasms Moreover, this method can accurately quantify let-7a expression at a single-cell level and can even distinguish the let-7a expression between non-small cell lung cancer patient tissues and healthy person tissues. +target gene 35000195 hsa-mir-591 Glioma CircABCC1 functions as an oncogene to promote the progression of glioma via the regulation of miR-591/HMGA2 signaling. +genetics_overexpression_suppress 35000146 hsa-mir-192 Endometrial Neoplasms Importantly, we indicated that miR-192-5p-overexpressed TAMs-derived exosomes regulated the EC cells apoptosis and EMT through inhibiting IRAK1/NF-kappaB signaling pathway. +tissue_expression_down 35000027 hsa-mir-556 Breast Neoplasms miR-556-5p was downregulated in breast cancer samples according to online datasets and experimental analyses. +target gene 34999395 hsa-mir-185 Neuralgia this study suggested that miR-185-5p chokes CCI-induced NP and neuroinflammation by targeting MyD88 and CXCR4 +target gene 34999393 hsa-mir-181a Pneumonia Mechanistically, PRP had the similar effects as miR-181a-5p antagomir on RSV-induced apoptosis and inflammation in HEp-2 cells via upregulating BCL2, MLL3 and SIRT1, which could be reversed by miR-181a-5p mimic. +target gene 34999254 hsa-mir-34a Cholangiocarcinoma miR-34a-5p directly targeted WNT7B and inhibited WNT7B expression. +lncRNA target 34999183 hsa-mir-141 Neuralgia miR-141 was reduced in CCI rats and restored by the lncRNA H19 knockdown, suggesting the potential negative associations of miR-141 with lncRNA H19. +tissue_expression_down 34999004 hsa-mir-200c COVID-19 At the time of admission, the expression levels of miR-200c-3p and miR-421-5p as well as CD4, CD25, and Foxp3 significantly decreased while IL-6 expression notably enhanced. +tissue_expression_down 34999004 hsa-mir-421 COVID-19 At the time of admission, the expression levels of miR-200c-3p and miR-421-5p as well as CD4, CD25, and Foxp3 significantly decreased while IL-6 expression notably enhanced. +circulation_biomarker_prognosis_down 34998954 hsa-mir-485 Neuroblastoma These miRNAs underwent genomic loss in a subset of neuroblastoma patients, and low expression predicted poor survival outcome. +circulation_biomarker_prognosis_down 34998954 hsa-mir-380 Neuroblastoma These miRNAs underwent genomic loss in a subset of neuroblastoma patients, and low expression predicted poor survival outcome. +circulation_biomarker_prognosis_down 34998954 hsa-mir-99b Neuroblastoma These miRNAs underwent genomic loss in a subset of neuroblastoma patients, and low expression predicted poor survival outcome. +transcription factor target 34998813 hsa-mir-122 Fibrosis, Renal Pharmacological inhibition of miR5p has potential therapeutic significance for hypertensive renal injury and fibrosis-related kidney diseases. +circulation_biomarker_prognosis_ns 34998434 hsa-let-7e Nasopharyngeal Carcinoma This study constructed a novel 5-miRNA signature for prognostic prediction of the survival of NPC patients and may be useful for individualized treatment of NPC patients. +circulation_biomarker_prognosis_ns 34998434 hsa-mir-647 Nasopharyngeal Carcinoma This study constructed a novel 5-miRNA signature for prognostic prediction of the survival of NPC patients and may be useful for individualized treatment of NPC patients. +circulation_biomarker_prognosis_ns 34998434 hsa-mir-93 Nasopharyngeal Carcinoma This study constructed a novel 5-miRNA signature for prognostic prediction of the survival of NPC patients and may be useful for individualized treatment of NPC patients. +circulation_biomarker_prognosis_ns 34998434 hsa-mir-26a Nasopharyngeal Carcinoma This study constructed a novel 5-miRNA signature for prognostic prediction of the survival of NPC patients and may be useful for individualized treatment of NPC patients. +epigenetics 34998421 hsa-mir-2355 Uterine Cervical Neoplasms H3K27ac-activated EGFR-AS1 sponged miR-2355-5p and promoted CC cell growth through ACTN4-mediated WNT pathway. +genetics_overexpression_suppress 34998382 hsa-mir-615 Colorectal Neoplasms Overexpression of miR-615 suppressed the growth of CRC cells. +target gene 34997970 hsa-mir-6755 Carcinoma, Hepatocellular In summary, LINC00924 increases NDRG2 expression to inhibit EMT by targeting miR-6755-5p in HBV-related HCC. +genetics_knock down_promote 34997887 hsa-mir-23b Inflammation Also, Sema3A overexpression reversed the effects of miR-23b-3p mimic on inflammation, proliferation, and apoptosis of HG-induced podocytes. +circulation_biomarker_diagnosis_ns 34997773 hsa-mir-21 Constriction, Pathologic CONCLUSION: Circulating lnc-GAS5 and its target miR-21 exhibit potency to serve as biomarkers for CHD management. +circulation_biomarker_diagnosis_ns 34997773 hsa-mir-21 Coronary Disease CONCLUSION: Circulating lnc-GAS5 and its target miR-21 exhibit potency to serve as biomarkers for CHD management. +transcription factor target 34997725 hsa-mir-25 Glioma Together, our data demonstrated that in glioma, miR3p may inhibit cancer cell growth through the suppression of FOXM1 and could be a promising new target for treating this type of brain cancer. +other 34997455 hsa-mir-626 Aortic Aneurysm, Abdominal This research was performed for the functional analysis of circ_0092291 and its mechanism exploration with mircoRNA-626 (miR-626) and collagen type IV alpha1 chain (COL4A1) in AAA. +circulation_biomarker_diagnosis_up 34997188 hsa-mir-181a Leigh Disease In brief, MMP-9 was negatively correlated with miR-181a-5p in serum and placenta of SPE patients. +circulation_biomarker_diagnosis_ns 34997188 hsa-mir-181a Pre-Eclampsia MMP-9 and miR-181a-5p in serum and placenta are associated with adverse outcomes This study explored the correlation of MMP-9 with miR-181a-5p in severe preeclampsia (SPE). +other 34997082 hsa-mir-29b Peritoneal Neoplasms The miR-29b family is downregulated in peritoneal fluids in patients with peritoneal metastases (PM). +transcription factor target 34997082 hsa-mir-29b Polymyalgia Rheumatica MiR-29b inhibits TGF-beta1 induced MMT and replacement of miR-29b in the peritoneal cavity might be effective to prevent development of PM partly through the effects on MC. +genetics_GWAS 34996981 hsa-mir-218 Stress Disorders, Traumatic Collectively, these findings establish the role of miR5p in chronic stress and the epigenetic function it plays to induce chromatin-based transcriptional changes of several CNS genes in triggering stress-induced disorders, including depression. +genetics_GWAS 34996981 hsa-mir-218 Neurotic Disorders 5p in chronic stress and the epigenetic function it plays to induce chromatin-based transcriptional changes of several CNS genes in triggering stress-induced disorders, including depression. +genetics_overexpression_promote 34996511 hsa-mir-205 Hepatoblastoma RESULTS: MIR205HG was significantly overexpressed in HB. +lncRNA target 34996049 hsa-mir-135b Femur Head Necrosis Taken together, this study indicates that ESWT relieves endothelial injury and dysfunction in steroid-induced ONFH via miR-135b targeting FOXO1. +other 34995020 hsa-mir-135b Inflammation In conclusion, the miR-135b/183-FOXO1/TXNIP/NLRP3 inflammasome axis might be a novel mechanism for Se to antagonize HgCl(2) -induced oxidative stress and inflammation in the central immune organs of chickens. +lncRNA target 34995020 hsa-mir-135b Thymus Neoplasms Most importantly, Se effectively attenuated the aforementioned damage in the thymus and BF caused by HgCl(2) and inhibited the TXNIP/NLRP3 inflammasome pathway by reversing the expression of FOXO1 through inhibiting miR-135b/183. +lncRNA target 34995020 hsa-mir-135b Behcet Syndrome Most importantly, Se effectively attenuated the aforementioned damage in the thymus and BF caused by HgCl(2) and inhibited the TXNIP/NLRP3 inflammasome pathway by reversing the expression of FOXO1 through inhibiting miR-135b/183. +other 34994989 hsa-mir-497 Colorectal Neoplasms PURPOSE: To investigate the BCL2/miRNA-497 expression ratio in colorectal cancer (CRC) and explore its association with the clinicopathological characteristics and CRC prognosis. CONCLUSION: The BCL2/miR497 expression ratio is associated with poor CRC prognosis in terms of metastasis and short survival. +genetics_overexpression_promote 34994952 hsa-mir-182 Urinary Bladder Neoplasms CRIM1 genes and miR-182 in UMUC3 cell lines were overexpressed and silenced, respectively, to investigate their effects on invasion and migration of bladder cancer, and to detect the changes of miR182/Foxo3a expression. +lncRNA target 34993814 hsa-mir-34a Breast Neoplasms Up-regulation of KCNQ1OT1 was shown to inhibit miR-34a which was associated with blocking the inhibitory effect of miR-34a on BC cell proliferation, migration and invasion. +genetics_overexpression_promote 34993725 hsa-mir-451a Breast Neoplasms U6 snRNA was remarkably overexpressed in all the validations, miR-548b-5p levels were generally elevated and miR-451a expression was mostly downregulated in breast cancer groups. CONCLUSIONS: Our results indicated that U6 snRNA and miR-548b-5p may have pro-oncogenic functions, while miR-451a may act as tumor suppressor in breast cancer. +genetics_overexpression_promote 34993725 hsa-mir-548b Breast Neoplasms U6 snRNA was remarkably overexpressed in all the validations, miR-548b-5p levels were generally elevated and miR-451a expression was mostly downregulated in breast cancer groups. CONCLUSIONS: Our results indicated that U6 snRNA and miR-548b-5p may have pro-oncogenic functions, while miR-451a may act as tumor suppressor in breast cancer. +genetics_knock down_promote 34993722 hsa-mir-30 Prostatic Neoplasms 5p expression, and circ_0044516 knockdown suppressed PCa cell proliferation, migration, invasion, and cycle progression by enriching miR +other 34993348 hsa-mir-363 Carcinoma, Non-Small-Cell Lung Long noncoding RNA NR2F1-AS1 stimulates the tumorigenic behavior of non-small cell lung cancer cells by sponging miR-363-3p to increase SOX4. +genetics_overexpression_suppress 34993211 hsa-mir-145a Diabetes Mellitus In conclusion, our findings suggest that rectifying macrophage function using miR-145a-5p overexpression accelerates diabetic chronic wound healing. +other 34993023 hsa-mir-200c Colorectal Neoplasms CONCLUSION: We constructed a ceRNA network of ERCC4 in CRC, of which the MALAT1-miR-200c-3p-ERCC4 axis may be involved in the development, prognosis and chemotherapy sensitivity of CRC. +other 34992689 hsa-mir-1182 Prostatic Neoplasms Mechanistic experiments showed that LINC01207 promoted carcinogenesis by sponging miR-1182 to regulate the protein levels of AKT3 in PC cell lines. +target gene 34992681 hsa-mir-21 Stomach Neoplasms GAS8-AS1 acts as a tumor suppressor in gastric cancer, and it may inhibit cancer cell proliferation by downregulating miR-21-3p. +genetics_overexpression_promote 34992672 hsa-mir-130a Carcinoma, Hepatocellular The ectopic overexpression of PTP4A2 promoted hepatoma cell proliferation in vitro, which could be reversed by miRNA-130a-5p. +genetics_GWAS 34992522 hsa-mir-124 Depressive Disorder, Major The aim of this study was to clarify the role of miR-124 methylation in MDD and antidepressant effects from the perspective of epigenetics. +genetics_GWAS 34992522 hsa-mir-124-1 Depressive Disorder, Major The aim of this study was to clarify the role of miR-124 methylation in MDD and antidepressant effects from the perspective of epigenetics. +other 34992508 hsa-mir-20a Alzheimer Disease We performed differential expression analysis, coexpression analysis, enrichment analysis, and hypergeometric tests to calculate the underlying regulatory effects of multifactors on the modules by the way of the whole gene expression profile of AD and identify a series of ncRNA (miR-320a) and TF (NFKB1). +lncRNA target 34992498 hsa-mir-766 psoriasis 1 3p expression levels and inhibiting activation of S1PR3 through the AKT/mTOR pathway in psoriasis. +other 34992456 hsa-mir-17 uterine corpus endometrial carcinoma 3p in UCEC. +other 34992456 hsa-mir-381 uterine corpus endometrial carcinoma 3p in UCEC. +other 34992456 hsa-mir-93 uterine corpus endometrial carcinoma 3p in UCEC. +lncRNA target 34992034 hsa-mir-518f Fetal Growth Retardation 5p and miR-518f-5p) expression with maternal, placental and newborn parameters and with their potential angiogenesis-associated target genes ENG, VEGF and FLT in a set of 68 small- (SGA, n = 30) and appropriate- (AGA, n = 38) for gestational age full-term singleton pregnancies, in relation to fetal sex. +transcription factor target 34992034 hsa-mir-517 Fetal Growth Retardation CONCLUSION: We conclude that placental miR5p could be playing a key role in the pathophysiology of fetal growth restriction, which can be potentially targeted through maternal lifestyle modifications for improving fetoplacental growth. +lncRNA target 34991683 hsa-mir-577 Squamous Cell Carcinoma of Head and Neck MiR-577 was found in OSCC with low expression, and RIP assays illustrated that NORAD, miR-577 and TPM4 coexisted in RNA-induced silencing complexes. CONCLUSIONS: It was revealed that NORAD functioned as a tumor promoter to sponge miR-577 thus elevating TPM4 in OSCC, which indicated that NORAD was worthy to be studied as a target for the treatment of OSCC. +other 34991629 hsa-mir-210 Stroke RESULTS: Here, we measured miR expression levels in astrocytes around human ischemic stroke lesions and observed differential expression of miR-210 in chronic stroke astrocytes compared to astrocytes from neurological control tissue. +other 34991629 hsa-mir-210 Ischemic Stroke RESULTS: Here, we measured miR expression levels in astrocytes around human ischemic stroke lesions and observed differential expression of miR-210 in chronic stroke astrocytes compared to astrocytes from neurological control tissue. CONCLUSIONS: We conclude that miR-210 expression in human astrocytes is modulated in response to ischemic stroke disease and under in vitro stress conditions, supporting a role for miR-210 in the astrocytic response to disease conditions. +other 34991609 hsa-mir-139 Carcinoma, Hepatocellular The SNHG3 and THUMPD3-AS1/hsa-miR5p-SLC52A2 axis were identified as potential regulatory pathways in hepatocellular carcinoma. +lncRNA target 34991445 hsa-mir-365a Osteosarcoma Function experiments showed the effects of HCG18 and miR-365a-3p on OS cell growth. CONCLUSION: HCG18 promoted OS cell proliferation via enhancing aerobic glycolysis by regulating the miR-365a-3p/PGK1 axis. +epigenetics 34990753 hsa-mir-20a Ovarian Neoplasms Through rescue experiments, we certified that miR-20a-5p inhibits the autophagy and cisplatin resistance in OvCa via DNMT3B-mediated DNA methylation of RBP1. +lncRNA target 34990740 hsa-mir-181a Thyroid Neoplasms These data illustrated that ZNF674-AS1 alleviated TC progression by modulating the miR-181a/SOCS4 axis (graphical abstract), further suggesting that ZNF674-AS1 might be used as a therapheutic target in TC treatment. +other 34990478 hsa-mir-34a Neonatal Sepsis Significant correlations of miR-34a-5p and miR-199a-3p with each of TLC, RDW, RBS, and C-reactive protein (CRP) as well as SNAPII were observed, indicating their associations with the severity of neonatal sepsis. CONCLUSION: miR-34a-5p and miR-199a-3p may be useful as novel biomarkers in neonatal sepsis and may provide a new direction for its treatment. +other 34990478 hsa-mir-199a Neonatal Sepsis Significant correlations of miR-34a-5p and miR-199a-3p with each of TLC, RDW, RBS, and C-reactive protein (CRP) as well as SNAPII were observed, indicating their associations with the severity of neonatal sepsis. CONCLUSION: miR-34a-5p and miR-199a-3p may be useful as novel biomarkers in neonatal sepsis and may provide a new direction for its treatment. +genetics_overexpression_promote 34990303 hsa-mir-128 Osteoarthritis 3p overexpression on OA progression. +other 34989810 hsa-mir-137 Neurotic Disorders Neuropsychological disorders such as depression and schizophrenia are associated with excessive fear and anhedonia, and have been linked to microRNA 137. +other 34989810 hsa-mir-137 Schizophrenia Neuropsychological disorders such as depression and schizophrenia are associated with excessive fear and anhedonia, and have been linked to microRNA 137. +other 34989810 hsa-mir-137 Cognition Disorders Neuropsychological disorders such as depression and schizophrenia are associated with excessive fear and anhedonia, and have been linked to microRNA 137. +other 34989810 hsa-mir-137 Phobic Disorders Neuropsychological disorders such as depression and schizophrenia are associated with excessive fear and anhedonia, and have been linked to microRNA 137. +other 34989810 hsa-mir-137 Anhedonia Neuropsychological disorders such as depression and schizophrenia are associated with excessive fear and anhedonia, and have been linked to microRNA 137. +other 34989596 hsa-mir-221 Liver Diseases 3p). +other 34989596 hsa-mir-20a Liver Diseases 3p). +other 34989596 hsa-mir-99a Liver Diseases 3p). +other 34989596 hsa-mir-17 Liver Diseases 3p). +other 34989596 hsa-mir-197 Liver Diseases 3p). +other 34989596 hsa-mir-122 Liver Diseases 3p). +other 34989596 hsa-let-7d Liver Diseases 3p). +genetics_GWAS 34989332 hsa-mir-218-2 Uterine Cervical Neoplasms CONCLUSION: Our study suggests that the rs11134527 polymorphism in the miR +lncRNA target 34989314 hsa-mir-511 Retinoblastoma 3p reversed the negative effects of silencing ZFPM2-AS1 and PAX6 on retinoblastoma cell viability and migration. +lncRNA target 34989308 hsa-mir-144 Schizophrenia 3p might be associated with schizophrenia through down-regulating ATP1B2, implicating new targets of schizophrenia treatment. +other 34989253 hsa-mir-124 Atherosclerosis Conclusion: MIAT/miR-124 axis mediated the effect of curcumin on atherosclerosis and altered cell apoptosis and proliferation, both in vivo and in vitro. +lncRNA target 34989145 hsa-mir-493 Carcinoma, Non-Small-Cell Lung 3p to increase RAB22A expression, which also offered an underlying targeted therapy for NSCLC treatment. +transcription factor target 34989130 hsa-mir-130 Pulmonary Arterial Hypertension In this study, using miRNA sequencing and real-time PCR, we found that FGF21 treatment inhibited miR-130 elevation in hypoxia-induced PAH in vitro and in vivo. In conclusion, this study revealed the protective effect and mechanism of FGF21 on PAH through regulation of the miR-130/PPARgamma axis, providing new ideas for the development of potential drugs for PAH based on FGF21. +genetics_overexpression_promote 34989110 hsa-mir-599 Breast Neoplasms MiR-599 interacted with the 3' untranslated region (3'UTR) of E2F3, and miR-599 overexpression-induced suppressive effect on cellular malignant potential was overturned by the accumulation of E2F3 in BC cells. +lncRNA target 34988853 hsa-mir-502 Leukemia, Myeloid, Acute 5p, and IGF1R might form a regulatory axis to affect the carcinogenicity of AML cells and provide potential targets for the treatment of AML. +exosome 34988777 hsa-mir-370 Carcinoma, Non-Small-Cell Lung 3p was downregulated in NSCLC tissues, cells and the exosomes from NSCLC cells compared with respective controls. +other 34988755 hsa-mir-125b Nasal Polyps miR-125b expression was significantly upregulated in NP tissues from patients with CRSwNP. +other 34988755 hsa-mir-125b Inflammation miR-125b expression was significantly upregulated in NP tissues from patients with CRSwNP. +lncRNA target 34988230 hsa-mir-455 Carcinoma, Hepatocellular In conclusion, HOXA-AS3 modulated the functions of HCC cells through the miR5p/PD-L1 axis. +circulation_biomarker_diagnosis_down 34988221 hsa-mir-101 Carcinoma, Hepatocellular CONCLUSION: The exosomal miR-101 and miR-125b panel in the serum may act as a noninvasive biomarker for HCC detection. +circulation_biomarker_diagnosis_down 34988221 hsa-mir-125b Carcinoma, Hepatocellular CONCLUSION: The exosomal miR-101 and miR-125b panel in the serum may act as a noninvasive biomarker for HCC detection. +lncRNA target 34988211 hsa-mir-648 esophagus adenocarcinoma In this study, we sought to identify immune-related genes (IRGs) that are targeted by miR-3648 and develop an EA multigene signature. +lncRNA target 34988188 hsa-mir-126 Carcinoma, Hepatocellular 3p dramatically abolish the inhibitive influence of sh-TMPO-AS1 on HCC development. +target gene 34988161 hsa-mir-376b Osteosarcoma MicroRNA-376b-3p targets RGS1 mRNA to inhibit proliferation, metastasis, and apoptosis in osteosarcoma. +other 34988135 hsa-mir-615 Hypertension More importantly, three hub genes (NOTCH1, FOXO3, and STAT3) were recognized according to PPI network and three promising circRNA-miRNA-mRNA regulatory axes were found in hypertensive rat aorta, including rno_circRNA_0005818/miR-615/NOTCH1, rno_circRNA_0009197/ miR5p/FOXO3, and rno_circRNA_0005818/miR-10b-5p/STAT3, respectively. +other 34988135 hsa-mir-509 Hypertension More importantly, three hub genes (NOTCH1, FOXO3, and STAT3) were recognized according to PPI network and three promising circRNA-miRNA-mRNA regulatory axes were found in hypertensive rat aorta, including rno_circRNA_0005818/miR-615/NOTCH1, rno_circRNA_0009197/ miR5p/FOXO3, and rno_circRNA_0005818/miR-10b-5p/STAT3, respectively. +other 34988028 hsa-mir-542 Carcinoma, Hepatocellular the miRNA-542-3p-RFX6-DTX2-NOTCH1 regulatory pathway played significant roles in the tumor progression of liver hepatocellular carcinoma. +other 34988018 hsa-mir-664b Urinary Bladder Neoplasms Our results also identified the MSC-AS1/hsa-miR-664b-3p/TTK regulatory axis, which may also play an important role in the progression of BC, but further research is needed to verify this result. +circRNA target 34987549 hsa-mir-150 Osteoporosis In conclusion, circRNA008876-miR5p-mRNA could be an important ceRNA network involved in senile osteoporosis, which provides potential biomarkers and therapeutic targets for senile osteoporosis. +circulation_biomarker_diagnosis_ns 34987392 hsa-mir-638 Hypertension, Pulmonary Results: The relative expression level of miR-638 in the plasma was lower in the PAH patients than that in the controls (p < 0.001). +other 34987319 hsa-mir-6856 Sleep Apnea, Obstructive 5pKcnq1ot1, neat1, Tsix, ERG, kdm2b, and Runx1 may be involved in the pathogenesis of OSAHS-related hypertension, which provided a theoretical basis for the mechanism research and clinical treatment of OSAHS. +other 34987319 hsa-mir-595 Sleep Apnea, Obstructive 5pKcnq1ot1, neat1, Tsix, ERG, kdm2b, and Runx1 may be involved in the pathogenesis of OSAHS-related hypertension, which provided a theoretical basis for the mechanism research and clinical treatment of OSAHS. +other 34987319 hsa-mir-22 Sleep Apnea, Obstructive 5pKcnq1ot1, neat1, Tsix, ERG, kdm2b, and Runx1 may be involved in the pathogenesis of OSAHS-related hypertension, which provided a theoretical basis for the mechanism research and clinical treatment of OSAHS. +transcription factor target 34987126 hsa-mir-150 Colorectal Neoplasms Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease. +transcription factor target 34987126 hsa-mir-155 Colorectal Neoplasms Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease. +transcription factor target 34987126 hsa-mir-125b Colorectal Neoplasms Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease. +transcription factor target 34987126 hsa-mir-150 Colitis Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease. +transcription factor target 34987126 hsa-mir-155 Inflammatory Bowel Diseases Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease. +transcription factor target 34987126 hsa-mir-150 Inflammatory Bowel Diseases Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease. +transcription factor target 34987126 hsa-mir-346 Colitis Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease. +transcription factor target 34987126 hsa-mir-125b Inflammatory Bowel Diseases Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease. +transcription factor target 34987126 hsa-mir-506 Colitis Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease. +transcription factor target 34987126 hsa-mir-506 Inflammatory Bowel Diseases Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease. +transcription factor target 34987126 hsa-mir-506 Colorectal Neoplasms Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease. +transcription factor target 34987126 hsa-mir-346 Colorectal Neoplasms Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease. +transcription factor target 34987126 hsa-mir-155 Colitis Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease. +transcription factor target 34987126 hsa-mir-346 Inflammatory Bowel Diseases Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease. +transcription factor target 34987126 hsa-mir-125b Colitis Stimulation of human intestinal epithelial cells (Caco-2) with 1000 muM of 5-ASA suppressed the levels of miR-125b, miR-150, miR-155, miR-346 and miR-506, which are known to be involved in the regulation of colitis and/or colorectal cancer in patients with inflammatory bowel disease. +circRNA target 34987010 hsa-mir-1915 Stomach Neoplasms CONCLUSIONS: Our study revealed that circ-ABCB10 promoted GC progression via targeting the miR3p/Rac1 axis, and circ-ABCB10 might be a potential target for GC diagnosis and treatment. +circulation_biomarker_diagnosis_up 34986898 hsa-mir-155 Toxoplasmosis RESULTS: We observed that Toxoplasma infection upregulated miR5p expression in DC2.4 cell-secreted exosomes, and those exosomes could be ingested by murine macrophage RAW264.7 cells. +genetics_knock down_promote 34986861 hsa-mir-1197 Atherosclerosis CONCLUSION: Our study revealed that knockdown of NCK1-AS1 attenuated the development of AS by regulating miR-1197/COX10 axis, suggesting that this lncRNA might be a potential therapeutic target for AS. +genetics_overexpression_suppress 34986816 hsa-mir-17 Acth-Independent Macronodular Adrenal Hyperplasia Overexpression of miR-17, miR-20a and miR-130b may inhibit glucocorticoid-induced apoptosis in PMAH pathogenesis. Specific miRNAs, such as miR-17, miR-20a and miR-130b, may be new targets for further functional studies of PMAH. +genetics_overexpression_suppress 34986816 hsa-mir-130b Acth-Independent Macronodular Adrenal Hyperplasia Overexpression of miR-17, miR-20a and miR-130b may inhibit glucocorticoid-induced apoptosis in PMAH pathogenesis. Specific miRNAs, such as miR-17, miR-20a and miR-130b, may be new targets for further functional studies of PMAH. +genetics_overexpression_suppress 34986816 hsa-mir-20a Acth-Independent Macronodular Adrenal Hyperplasia Overexpression of miR-17, miR-20a and miR-130b may inhibit glucocorticoid-induced apoptosis in PMAH pathogenesis. Specific miRNAs, such as miR-17, miR-20a and miR-130b, may be new targets for further functional studies of PMAH. +genetics_knock down_suppress 34986757 hsa-mir-142 Carcinoma, Hepatocellular 3p knockdown's influence on HCC in vivo. +lncRNA target 34986743 hsa-mir-1270 Stomach Neoplasms Therefore, ASMTL-AS1/miR-1270 may be a potential prognostic biomarker and novel strategy for gastric cancer targeted therapy. +other 34986654 hsa-mir-338 Fibrosis In this paper, we identify miR3p as a microRNA severely downregulated in the lungs of patients with pulmonary fibrosis and in experimental models of pulmonary fibrosis. +other 34986654 hsa-mir-338 Pulmonary Fibrosis In this paper, we identify miR3p as a microRNA severely downregulated in the lungs of patients with pulmonary fibrosis and in experimental models of pulmonary fibrosis. +genetics_knock down_promote 34986537 hsa-mir-186 Liver Neoplasms Knockdown of miR +transcription factor target 34986481 hsa-mir-27b Testicular Diseases CONCLUSION: miR-27b-3p could improve HG-induced spermatogenic cell damage via regulating Gfpt1/HBP signaling, providing a new treatment strategy for the treatment of DM-induced testicular damage. +transcription factor target 34986481 hsa-mir-27b Diabetes Mellitus CONCLUSION: miR-27b-3p could improve HG-induced spermatogenic cell damage via regulating Gfpt1/HBP signaling, providing a new treatment strategy for the treatment of DM-induced testicular damage. +genetics_overexpression_promote 34985712 hsa-mir-21 Carcinoma, Renal Cell CONCLUSION: Expression of ACAT1 in KIRC is controlled at two levels, firstly by the hypermethylation of the ACAT1 promoter region and secondly by overexpression of miR +transcription factor target 34985594 hsa-mir-34a Colorectal Neoplasms Among them, AM22, with a base alteration from G to C at the 17(th) nucleotide of miR-34a, showed extensive antiproliferative activity against several colorectal tumor cell lines and achieved effective inhibition of core binding factor subunit beta (CBFB) expression. +other 34985397 hsa-mir-1 Diabetes Mellitus 5p mimics to treat the diabetic wound. +genetics_overexpression_promote 34985193 hsa-mir-619 Carcinoma, Non-Small-Cell Lung 5p overexpression inhibited NSCLC cell colony formation, migration, invasion, glycolysis and promoted cell apoptosis in vitro. +lncRNA target 34984723 hsa-mir-218 ankylosing spondylitis 1 OBJECTIVE: To investigate bone mineral density (BMD), bone metabolism-related factors, and microRNA-218 in Chinese ankylosing spondylitis (AS) patients and to identify their correlation with disease activities and the treatment with TNF-alpha inhibitors. +target gene 34984191 hsa-mir-200a Urinary Bladder Neoplasms miR-200a-3p facilitates bladder cancer cell proliferation by targeting the A20 gene. +other 34984022 hsa-mir-135a Myocardial Fibrosis CONCLUSION: We speculated that LINC00664/hsa-miR3p/JAK2 and GAS6-AS1/SNHG22/hsa-miR-135a-5p/CENPB/BCL9L interaction pairs may serve as potential biomarkers in MF after AMI. +other 34984022 hsa-mir-135a Myocardial Infarction CONCLUSION: We speculated that LINC00664/hsa-miR3p/JAK2 and GAS6-AS1/SNHG22/hsa-miR-135a-5p/CENPB/BCL9L interaction pairs may serve as potential biomarkers in MF after AMI. +other 34983931 hsa-mir-190b Depression, Postpartum In conclusion, cinnamaldehyde is a potential intervening agent for intergenerational inheritance of depression, probably by regulating GR/miR-190b/BDNF pathway. +lncRNA target 34983906 hsa-let-7d Diabetic Cardiomyopathies A total of 5 miRNAs were downregulated in the myocardial tissues of DCM rats and upregulated in H3 relaxin-treated DCM rats, and 1 miRNA (miRNA let-7d-3p) was increased in the myocardial tissue of DCM rats and decreased in H3 relaxin-treated DCM rats as revealed by miRNA microarray and validated by real-time polymerase chain reaction. The study revealed that H3 relaxin improved glucose uptake in DCM rats, potentially via the regulation of miRNA let-7d-3p. +circulation_biomarker_diagnosis_up 34983881 hsa-mir-186 Ischemic Stroke 5p is verified to be elevated in serum from ischaemic stroke patients. +other 34983831 hsa-mir-132 Parkinson Disease 3p and decreased expression of GLRX were found in PD patients and cells models. +lncRNA target 34983617 hsa-mir-550a Breast Neoplasms Further molecular mechanism research showed that circCCDC85A may act as a molecular sponge for miR-550a-5p, thus restoring miR-550a-5p-mediated targeting repression of tumor suppressor MOB1A in breast cancer cells. +genetics_knock down_suppress 34983615 hsa-mir-25 Multiple Myeloma Using RNA and microRNA sequencing, we identified miR-551b and miR-25 as important miRs mediating Dex resistance in MM. Overexpression of miR-551b and miR-25 caused resistance to Dex, however, knockdown of miR-551b and miR-25 significantly enhanced Dex sensitivity in MM. +genetics_knock down_suppress 34983615 hsa-mir-551b Multiple Myeloma Using RNA and microRNA sequencing, we identified miR-551b and miR-25 as important miRs mediating Dex resistance in MM. Overexpression of miR-551b and miR-25 caused resistance to Dex, however, knockdown of miR-551b and miR-25 significantly enhanced Dex sensitivity in MM. +genetics_overexpression_promote 34983607 hsa-mir-32 Ovarian Neoplasms MiR5p could be sponged by circ_0078607, and its overexpression could reverse the suppressive effect of circ_0078607 on OC progression. +genetics_overexpression_promote 34983591 hsa-mir-653 Arthritis, Rheumatoid Functional assays showed that FGF2 overexpression neutralized the suppressive effects of miR +exosome 34983581 hsa-mir-155 Medulloblastoma 3p from M2 macrophages-derived exosomes (M2-Exo) in promoting medulloblastoma (MB) progression by mediating WD repeat domain 82 (WDR82). +genetics_overexpression_promote 34983563 hsa-mir-21 Myocardial Ischemia In cardiomyocytes, ciRs-126 overexpression decreased miR-21 level and reduced the inhibitory effects of miR-21 overexpression on H/R-induced cell apoptosis. +lncRNA target 34983537 hsa-mir-497 Pancreatic Carcinoma CONCLUSION: The upregulated circRTN4 promotes tumor growth and liver metastasis in PDAC through the novel circRTN4-miR +other 34983361 hsa-mir-29b Carcinoma, Ovarian Epithelial RESULTS: Abnormal expression of HCG18 and miR-29a/b was observed in EOC tissues. CONCLUSIONS: Taken together, our data revealed an oncogenic signalling pathway mediated by HCG18 in ovarian cell lines, which functions as a ceRNA of miR-29a/b and thus derepresses expression levels of TRAF4/5, facilitating NF-kappaB pathway-mediated promotion of EOC cell proliferation and migration. +other 34983361 hsa-mir-29a Carcinoma, Ovarian Epithelial RESULTS: Abnormal expression of HCG18 and miR-29a/b was observed in EOC tissues. CONCLUSIONS: Taken together, our data revealed an oncogenic signalling pathway mediated by HCG18 in ovarian cell lines, which functions as a ceRNA of miR-29a/b and thus derepresses expression levels of TRAF4/5, facilitating NF-kappaB pathway-mediated promotion of EOC cell proliferation and migration. +genetics_overexpression_suppress 34983308 hsa-mir-22 Carcinoma, Hepatocellular Overexpression of miR +genetics_overexpression_promote 34983307 hsa-mir-373 Carcinoma, Hepatocellular 3p was downregulated, and its overexpression stepped up HCC cell apoptosis and suppressed migration and EMT. +lncRNA target 34983293 hsa-mir-1306 Carcinoma, Pancreatic Ductal Our findings suggest that circUHRF1 regulated ARL4C expression to promote PDAC progression through sponging miR +genetics_knock down_promote 34982425 hsa-mir-195 Gallbladder Neoplasms 5p markedly attenuated the proliferation capacity of GBC cells as compared to the NC mimic group; in contrast, knockdown of microRNA +circRNA target 34982356 hsa-mir-1281 Glioma MiR-1281 also inhibited glioma malignant progression by targeting ERBB4. +genetics_knock down_promote 34982022 hsa-mir-515 Carcinoma, Squamous Cell, Cutaneous TPX2 overexpression largely overturned miR +circulation_biomarker_diagnosis_down 34981911 hsa-mir-423 Asthma 5p was downregulated in the serum of BA patients and was negatively correlated with PVT1. +lncRNA target 34981821 hsa-mir-96 Sepsis In addition, GMDSAS1 expression increased, and upregulation of GMDSAS1 inhibited, the expression of miR965p in the in vitro sepsis model. In summary, the findings of the present study demonstrated that lncRNA GMDSAS1 could promote the development of sepsis by targeting miR965p/CASP2, indicating that the GMDSAS1/miR965p/CASP2 axis may be a new therapeutic target and potential research direction for sepsis therapy. +genetics_knock down_promote 34981816 hsa-mir-20b Ceroid lipofuscinosis, neuronal 5 Taken together, the results of the present study suggest that NEAT1 knockdown promotes phenotypic transformation of AMs from M1 to M2 and alleviates lung injury and apoptosis of VILI by regulating miR20b expression. +genetics_knock down_promote 34981816 hsa-mir-20b Lung Injury Taken together, the results of the present study suggest that NEAT1 knockdown promotes phenotypic transformation of AMs from M1 to M2 and alleviates lung injury and apoptosis of VILI by regulating miR20b expression. +other 34981813 hsa-mir-29c Leukemia, Lymphocytic, Chronic, B-Cell Moreover, the expression levels of miR15a and miRNA29c were demonstrated to be significantly higher in the group of patients with CLL who had a tumor protein p53 deletion, identified by FISH, compared with patients without this lesion (P=0.047, P=0.03 respectively). +genetics_overexpression_promote 34981812 hsa-mir-1291 Colonic Neoplasms Furthermore, miR1291 induced CDK inhibitors p21(WAF1/CIP1) and p27(KIP1) in three CRC cell lines, and the overexpression of DCLK1 in HCT116 cells led to a decrease of p21(WAF1/CIP1) and p27(KIP1). +other 34981661 hsa-mir-185 Pulmonary Arterial Hypertension 5p, are significantly associated with IPAH. +other 34981661 hsa-mir-103a Pulmonary Arterial Hypertension 5p, are significantly associated with IPAH. +other 34981461 hsa-mir-30 Pneumonia, Mycoplasma Our study identifies circ_0017068 as an important regulator of the proliferation and apoptosis of HTR-8/SVneo trophoblast cells at least in part by miR5p-dependent regulation of XIAP, highlighting circ_0017068 as a potential therapeutic agent for PE treatment. +genetics_GWAS 34981334 hsa-mir-146a Brucellosis Current research studied the impact of the miR-146a polymorphism on miR-146a, TRAF-6, and IRAK-1 genes expression in patients with brucellosis illness. +lncRNA target 34981333 hsa-mir-34a Salivary Gland Neoplasms METHODS AND RESULTS: The expression of microRNAs miR-9, miR-34a, miR-101, miR-138, miR-155, and miR-200c-described in the literature to target EMT factors-was evaluated by Real-time RT-PCR (qPCR) in pleomorphic adenoma (PA), mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) samples. +lncRNA target 34981333 hsa-mir-9 Salivary Gland Neoplasms METHODS AND RESULTS: The expression of microRNAs miR-9, miR-34a, miR-101, miR-138, miR-155, and miR-200c-described in the literature to target EMT factors-was evaluated by Real-time RT-PCR (qPCR) in pleomorphic adenoma (PA), mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) samples. +lncRNA target 34981333 hsa-mir-155 Salivary Gland Neoplasms METHODS AND RESULTS: The expression of microRNAs miR-9, miR-34a, miR-101, miR-138, miR-155, and miR-200c-described in the literature to target EMT factors-was evaluated by Real-time RT-PCR (qPCR) in pleomorphic adenoma (PA), mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) samples. +lncRNA target 34981333 hsa-mir-138 Salivary Gland Neoplasms METHODS AND RESULTS: The expression of microRNAs miR-9, miR-34a, miR-101, miR-138, miR-155, and miR-200c-described in the literature to target EMT factors-was evaluated by Real-time RT-PCR (qPCR) in pleomorphic adenoma (PA), mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) samples. +lncRNA target 34981333 hsa-mir-101 Salivary Gland Neoplasms METHODS AND RESULTS: The expression of microRNAs miR-9, miR-34a, miR-101, miR-138, miR-155, and miR-200c-described in the literature to target EMT factors-was evaluated by Real-time RT-PCR (qPCR) in pleomorphic adenoma (PA), mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) samples. +lncRNA target 34981333 hsa-mir-200c Salivary Gland Neoplasms METHODS AND RESULTS: The expression of microRNAs miR-9, miR-34a, miR-101, miR-138, miR-155, and miR-200c-described in the literature to target EMT factors-was evaluated by Real-time RT-PCR (qPCR) in pleomorphic adenoma (PA), mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) samples. +genetics_overexpression_suppress 34981113 hsa-mir-335 Endothelial Dysfunction 5p inhibitor attenuated the down-regulation of SIRT7 expression induced by oxidative stress in HUVECs, and SIRT7 overexpression exerts a rescue effect against miR +other 34981016 hsa-mir-144 Multiple Sclerosis MIR-144 can be used as a biomarker of MS and help to early diagnosis and treatment of this disease. +other 34980214 hsa-mir-24 Ovarian Neoplasms 3p/LY6K signaling to facilitate progression of ovarian cancer. +genetics_knock down_suppress 34980204 hsa-mir-23a Carcinoma, Hepatocellular CRISPR-Cas9 knockout of miR-23a-3p improved sorafenib response in HCC cells as well as orthotopic HCC tumours. +other 34980201 hsa-mir-195 Carcinoma, Hepatocellular CONCLUSIONS: Our finding indicated that there existed a TINCR/miR3p/ST6GAL1/NF-kappaB signaling regulatory axis that regulated tumor progression and oxaliplatin resistance, which might be exploited for anticancer therapy in HCC. +lncRNA target 34980191 hsa-mir-100 Nasopharyngeal Carcinoma In addition, we confirmed that ZFAS1 can regulate the autophagy level of NPC cells through the PI3K/AKT pathway through miR +genetics_knock down_promote 34980181 hsa-mir-125a Multiple Myeloma Knockdown of miR-125a-5p or miR-125b-5p significantly enhanced the proliferation and migration of MM.1S and U266 cells, and co-transfection of sh-Bcl-2 and miR-125a/b-5p inhibitor inhibited cell proliferation compared with that in miR-125a/b-5p inhibitor group. +genetics_knock down_promote 34980181 hsa-mir-125b Multiple Myeloma Knockdown of miR-125a-5p or miR-125b-5p significantly enhanced the proliferation and migration of MM.1S and U266 cells, and co-transfection of sh-Bcl-2 and miR-125a/b-5p inhibitor inhibited cell proliferation compared with that in miR-125a/b-5p inhibitor group. +other 34980144 hsa-mir-23b Liver Neoplasms CONCLUSION: T cell-related RNAs EOMES, CST7, CD5L, has-miR-23b-3p, and has-miR-23a-3p may be associated with the prognosis of liver cancer. +other 34980144 hsa-mir-23a Liver Neoplasms CONCLUSION: T cell-related RNAs EOMES, CST7, CD5L, has-miR-23b-3p, and has-miR-23a-3p may be associated with the prognosis of liver cancer. +lncRNA target 34980138 hsa-mir-181b Craniopharyngioma miR-181b, the expression of which was increased in Bmp2-induced ACP cells, directly targeted and decreased CBX4 expression and inhibited the nuclear localization of HDAC3. CONCLUSIONS: Our results demonstrate that Bmp2 increases miR-181b levels to directly target and inhibit CBX4 expression, leading to a reduction in the CBX4-dependent regulation of HDAC3 nuclear translocation, which results in Runx2 activation/osteoblastic differentiation and calcium deposition in ACP. +other 34979848 hsa-mir-19a Triple Negative Breast Neoplasms miRNAs that showed high differential expression in AA TNBC patients compared to EA included: miR-19a, miR-192, miR-302a, miR-302b, miR-302c, miR-335, miR-520b, miR-520f and miR-645. +other 34979848 hsa-mir-520f Triple Negative Breast Neoplasms miRNAs that showed high differential expression in AA TNBC patients compared to EA included: miR-19a, miR-192, miR-302a, miR-302b, miR-302c, miR-335, miR-520b, miR-520f and miR-645. +other 34979848 hsa-mir-520b Triple Negative Breast Neoplasms miRNAs that showed high differential expression in AA TNBC patients compared to EA included: miR-19a, miR-192, miR-302a, miR-302b, miR-302c, miR-335, miR-520b, miR-520f and miR-645. +other 34979848 hsa-mir-335 Triple Negative Breast Neoplasms miRNAs that showed high differential expression in AA TNBC patients compared to EA included: miR-19a, miR-192, miR-302a, miR-302b, miR-302c, miR-335, miR-520b, miR-520f and miR-645. +other 34979511 hsa-mir-622 Osteoarthritis CONCLUSION: CircCCDC66 promoted OA chondrocyte apoptosis by regulating the miR-3622b-5p/SIRT3 axis. +genetics_overexpression_suppress 34979422 hsa-mir-582 Urinary Bladder Neoplasms Overexpression of FOXG1 rescued the regulating function in BCa cells induced by miR-582. +lncRNA target 34979378 hsa-mir-21 Lung Neoplasms 5p inhibitor can more effectively suppress the development of lung cancer. +other 34979377 hsa-mir-92a Osteoarthritis Collectively, MF regulated the biological functions of OA synoviocytes by upregulating miR-92a-3p expression. +genetics_overexpression_suppress 34979376 hsa-mir-369 Carcinoma, Hepatocellular Concurrently, HOXA13 overexpression could counteract the effects of miR +other 34979347 hsa-mir-223 Cognition Disorders CONCLUSION: Propofol reduced inflammation by up-regulating miR3p, thereby reducing POCD in aged rats. +other 34979168 hsa-mir-20b Inflammation In summary, this study suggested that LncRNA2264 acted as a miR-20b-5p molecular sponge to regulate the expression of IL17RD involved in H(2)S exposure-induced thymic inflammation, which has positive implications for guiding the prevention and control of H(2)S gas poisoning in livestock housing and ensuring animal welfare. +circulation_biomarker_prognosis_ns 34979060 hsa-mir-601 Lung Neoplasms The aim of this study is to examine miRNA-601 and PD-L1 gene expression in patients with non-small-cell lung cancer (NSCLC) and its relation with Mycoplasma infection. CONCLUSION: Serum miRNA-601 may act as a potential noninvasive biomarker for lung cancer and Mycoplasma infection prognosis. +circulation_biomarker_prognosis_ns 34979060 hsa-mir-601 Mycoplasma Infections The aim of this study is to examine miRNA-601 and PD-L1 gene expression in patients with non-small-cell lung cancer (NSCLC) and its relation with Mycoplasma infection. CONCLUSION: Serum miRNA-601 may act as a potential noninvasive biomarker for lung cancer and Mycoplasma infection prognosis. +genetics_overexpression_suppress 34978893 hsa-mir-769 Carcinoma, Non-Small-Cell Lung Furthermore, more research revealed that HDGF overexpression reduced the inhibitory effect of miR +transcription factor target 34978772 hsa-mir-181a Allergic Inflammation CONCLUSION: The results suggest that miR-181a-5p restricted allergic inflammation through inhibition of IL-33/p38 MAPK pathway, indicating miR-181a-5p may play an anti-inflammatory role in AR. +genetics_knock down_suppress 34978519 hsa-mir-582 Triple Negative Breast Neoplasms 5p enhanced TNBC cell migration and invasion, whereas knockdown of miR +lncRNA target 34978518 hsa-mir-6720 Diabetic Retinopathy 5p and regulate the expression of CYB5R2, thereby inhibiting DR neovascularization. +genetics_overexpression_promote 34978464 hsa-mir-655 Carcinoma, Hepatocellular SMAD5, which was overexpressed in HCC cell lines, was directly targeted by miR +circRNA target 34978116 hsa-mir-23a Reperfusion Injury, Cerebral Ischemia In conclusion, circCDC14A promoted CI/R injury by regulating the miR-23a-3p/CXCL12 axis, which suggested that circCDC14A may become a potential therapeutic target for CI/R injury. +other 34978042 hsa-mir-127 Pneumonia, Mycoplasma Our research indicated that circPAPPA positively regulated the biological function of trophoblast cells to mediate the progression of PE by miR5p/HOXA7 axis, which suggested that circPAPPA might be a potential biomarker for PE. +exosome 34978010 hsa-mir-744 Glioma AIM: Our current study is conducted with intention to explore the regulatory mechanism of mesenchymal stem cell (MSC)-derived extracellular vesicle (EV)-miR +lncRNA target 34977878 hsa-mir-335 Adenocarcinoma of Lung Here, we revealed that hsa-miR-335, a previously reported tumor suppressor, exhibited an oncogenic role in LAC. This finding not only highlights the suppressive effect of CPNE1 on cell motility, but also provides new insight into miR-335 in promoting LAC metastasis. +circulation_biomarker_diagnosis_up 34977596 hsa-mir-455 Osteoarthritis, Post-Traumatic The number of differentially expressed microRNAs in serum was higher, some in common with joint tissues including miR +circulation_biomarker_diagnosis_up 34977596 hsa-mir-23b Osteoarthritis, Post-Traumatic The number of differentially expressed microRNAs in serum was higher, some in common with joint tissues including miR +circulation_biomarker_diagnosis_up 34977596 hsa-mir-499 Osteoarthritis, Post-Traumatic The number of differentially expressed microRNAs in serum was higher, some in common with joint tissues including miR +circulation_biomarker_diagnosis_up 34977596 hsa-mir-140 Osteoarthritis, Post-Traumatic The number of differentially expressed microRNAs in serum was higher, some in common with joint tissues including miR +circulation_biomarker_diagnosis_up 34977596 hsa-mir-5099 Osteoarthritis, Post-Traumatic The number of differentially expressed microRNAs in serum was higher, some in common with joint tissues including miR +circulation_biomarker_diagnosis_up 34977596 hsa-mir-6238 Osteoarthritis, Post-Traumatic The number of differentially expressed microRNAs in serum was higher, some in common with joint tissues including miR +target gene 34977284 hsa-mir-218 Osteosarcoma MiRNA-218 inhibits cell proliferation, migration and invasion by targeting Runt-related transcription factor 2 (Runx2) in human osteosarcoma cells. +circulation_biomarker_diagnosis_ns 34977204 hsa-mir-146a Rhiny Five known miRNAs (let-7g, miR-16b, miR-30e, miR-143, and miR-146a) were selected for further assessment via RT-qPCR in serum from black (n = 61 samples; seven individuals) and Sumatran (n = 38 samples; five individuals) rhinos. +circulation_biomarker_diagnosis_ns 34977204 hsa-let-7g Intervertebral disc disease let-7g, miR-30e, and miR-143 all showed significant increased expression (P 0.05) during IOD (between 1 and 2 years prior to death) and late IOD (within 1 year of death) compared to healthy and unhealthy individuals. Selected serum miRNAs of black and Sumatran rhinos, in particular let-7g, miR-30e, and miR-143, could therefore provide a tool for advancing rhino IOD diagnostics that should be further investigated. +circulation_biomarker_diagnosis_ns 34977204 hsa-mir-16b Rhiny Five known miRNAs (let-7g, miR-16b, miR-30e, miR-143, and miR-146a) were selected for further assessment via RT-qPCR in serum from black (n = 61 samples; seven individuals) and Sumatran (n = 38 samples; five individuals) rhinos. +circulation_biomarker_diagnosis_ns 34977204 hsa-mir-143 Rhiny Five known miRNAs (let-7g, miR-16b, miR-30e, miR-143, and miR-146a) were selected for further assessment via RT-qPCR in serum from black (n = 61 samples; seven individuals) and Sumatran (n = 38 samples; five individuals) rhinos. Selected serum miRNAs of black and Sumatran rhinos, in particular let-7g, miR-30e, and miR-143, could therefore provide a tool for advancing rhino IOD diagnostics that should be further investigated. +circulation_biomarker_diagnosis_ns 34977204 hsa-let-7g Body Integrity Identity Disorder Selected serum miRNAs of black and Sumatran rhinos, in particular let-7g, miR-30e, and miR-143, could therefore provide a tool for advancing rhino IOD diagnostics that should be further investigated. +circulation_biomarker_diagnosis_ns 34977204 hsa-let-7g Rhiny Five known miRNAs (let-7g, miR-16b, miR-30e, miR-143, and miR-146a) were selected for further assessment via RT-qPCR in serum from black (n = 61 samples; seven individuals) and Sumatran (n = 38 samples; five individuals) rhinos. Selected serum miRNAs of black and Sumatran rhinos, in particular let-7g, miR-30e, and miR-143, could therefore provide a tool for advancing rhino IOD diagnostics that should be further investigated. +circulation_biomarker_diagnosis_ns 34977204 hsa-mir-143 Intervertebral disc disease let-7g, miR-30e, and miR-143 all showed significant increased expression (P 0.05) during IOD (between 1 and 2 years prior to death) and late IOD (within 1 year of death) compared to healthy and unhealthy individuals. Selected serum miRNAs of black and Sumatran rhinos, in particular let-7g, miR-30e, and miR-143, could therefore provide a tool for advancing rhino IOD diagnostics that should be further investigated. +other 34977204 hsa-mir-16b Intervertebral disc disease miR-16b expression increased (P 0.05) in late IOD, but was not different among IOD, healthy, and unhealthy states (P > 0.05). +other 34977204 hsa-mir-146a Intervertebral disc disease Expression of miR-146a increased in IOD and late IOD as compared to unhealthy samples (P 0.05) but was not different from the healthy state (P > 0.05). +circulation_biomarker_diagnosis_ns 34977204 hsa-mir-143 Body Integrity Identity Disorder Selected serum miRNAs of black and Sumatran rhinos, in particular let-7g, miR-30e, and miR-143, could therefore provide a tool for advancing rhino IOD diagnostics that should be further investigated. +other 34977182 hsa-mir-153 Endomyocardial Fibrosis Recovery experiments with miR3p antagomir resulted in the reversal of FA-induced cardiomyocyte apoptosis and fetal cardiac fibrosis. +transcription factor target 34977182 hsa-mir-153 Coronary Disease The study findings suggest that miR3p may provide a potential target for the clinical diagnosis and treatment of CHD. +genetics_GWAS 34977033 hsa-mir-1269b Diabetic Nephropathies MiR-1269b-FBLN1 epigenetic regulatory network could be a potential therapeutic strategy to prevent the progression of DN. +transcription factor target 34977023 hsa-mir-375 Diabetic Retinopathy 3p is a potential target for the diagnosis or treatment of DR. +target gene 34977016 hsa-mir-101 Carcinoma, Non-Small-Cell Lung Cancer-Associated Fibroblasts Promote Migration and Invasion of Non-Small Cell Lung Cancer Cells via miR-101-3p Mediated VEGFA Secretion and AKT/eNOS Pathway. +lncRNA target 34977002 hsa-mir-1179 ankylosing spondylitis 1 Through dual-luciferase assays and RNA pull-down assays, we demonstrated that hsa_circ_0000652 acted as a competing endogenous RNA (ceRNA) by binding with hsa-miR-1179 and regulated OX40L, which is characterized as a co-stimulatory molecule and found to be upregulated in AS patients. Our findings suggest that hsa_circ_0000652 was upregulated in AS patients and may serve as a pro-inflammatory factor in macrophages and a positive regulator of OX40/OX40L by sponging hsa-miR-1179. +target gene 34976998 hsa-mir-103a Breast Neoplasms Long Noncoding RNA HCG18 Promotes Malignant Phenotypes of Breast Cancer Cells via the HCG18/miR-103a-3p/UBE2O/mTORC1/HIF-1α-Positive Feedback Loop. +target gene 34976797 hsa-mir-20a Carcinoma, Hepatocellular MicroRNA-20a Suppresses Tumor Proliferation and Metastasis in Hepatocellular Carcinoma by Directly Targeting EZH1. +genetics_overexpression_promote 34976438 hsa-mir-574 Insulin Resistance The overexpression of miR +other 34976438 hsa-mir-574 Diabetes Mellitus, Type 2 Additionally, miR5p expression was significantly higher in the subcutaneous adipose tissue of obese patients without type 2 diabetes than in those with type 2 diabetes. +transcription factor target 34976438 hsa-mir-574 Obesity 5p may be a potential therapeutic target for combating obesity-related IR. +circulation_biomarker_diagnosis_ns 34976409 hsa-mir-29b Coronary Artery Disease CONCLUSIONS: These data suggest that circulating miRNA-29b and sclerostin levels are correlated with CAC and incidence of CVEs in MHD patients. +circulation_biomarker_diagnosis_ns 34976409 hsa-mir-29b Coronary Artery Calcification CONCLUSIONS: These data suggest that circulating miRNA-29b and sclerostin levels are correlated with CAC and incidence of CVEs in MHD patients. +lncRNA target 34976325 hsa-mir-24 Pancreatic Carcinoma CONCLUSION: LINC01320 is highly expressed in PC, and it can suppress the growth and migration of PC cells through targeted regulation of miR3p, which is expected to become a latent target for clinical treatment. +lncRNA target 34976303 hsa-mir-155 Encephalomyelitis, Autoimmune, Experimental In summary, our study suggests that APS regulates the polarization of microglia from M1 to M2 phenotype by inhibiting the miR-155, reduces the secretion of inflammatory factors, and inhibits the activation of neurotoxic astrocytes, thus effectively treating EAE. +target gene 34976194 hsa-mir-424 Prostatic Neoplasms Long non-coding RNA MAGI2-AS3 inactivates STAT3 pathway to inhibit prostate cancer cell proliferation via acting as a microRNA-424-5p sponge. +other 34976193 hsa-mir-5703 Liver Neoplasms The expression of miRNA-5703 was higher in liver cancer tissues from Barcelona Clinic Liver Cancer (BCLC) stage A1 patients than those from BCLC stage A2-D patients, whereas SRC showed the opposite expression pattern. +other 34976187 hsa-mir-495 Colorectal Neoplasms HGF/c-MET regulatory network involved in cetuximab resistance in CRC. +target gene 34976171 hsa-mir-449a Carcinoma, Hepatocellular Ago-RIP Sequencing Identifies New MicroRNA-449a-5p Target Genes Increasing Sorafenib Efficacy in Hepatocellular Carcinoma. +target gene 34976169 hsa-mir-519 Pancreatic Neoplasms Hsa_circ_0074298 promotes pancreatic cancer progression and resistance to gemcitabine by sponging miR-519 to target SMOC. +other 34976151 hsa-mir-215 Breast Neoplasms Long non-coding RNA GAS6-AS1 enhances breast cancer cell aggressiveness by functioning as a competing endogenous RNA of microRNA-215-5p to enhance SOX9 expression. +target gene 34976140 hsa-mir-130b Prostatic Neoplasms miR-130b suppresses the invasion and migration of prostate cancer via inhibiting DLL1 and regulating the PI3K/Akt pathways. +target gene 34976139 hsa-mir-141 Squamous Cell Carcinoma of Head and Neck MicroRNA-141-3p inhibits the progression of oral squamous cell carcinoma via targeting PBX1 through the JAK2/STAT3 pathway. +other 34976024 hsa-mir-27b Graves Ophthalmopathy Conclusion: An innovative lncRNA/circRNA-miRNA-mRNA ceRNA network between GO patients and control patients was constructed, and two important ceRNA pathways were identified, the LINC01820:13-hsa-miR-27b-3p-FPR2 ceRNA pathway and the ENST00000499452-hsa-miR-27a-3p-CXCL1 pathway, which probably affect the autoimmune response and inflammation in GO patients. +other 34976024 hsa-mir-27a Graves Ophthalmopathy Conclusion: An innovative lncRNA/circRNA-miRNA-mRNA ceRNA network between GO patients and control patients was constructed, and two important ceRNA pathways were identified, the LINC01820:13-hsa-miR-27b-3p-FPR2 ceRNA pathway and the ENST00000499452-hsa-miR-27a-3p-CXCL1 pathway, which probably affect the autoimmune response and inflammation in GO patients. +target gene 34976014 hsa-mir-326 Uterine Cervical Neoplasms Downregulation of hsa_circRNA_0001400 Helps to Promote Cell Apoptosis Through Disruption of the circRNA_0001400-miR-326 Sponge in Cervical Cancer Cells. +other 34976005 hsa-mir-200a Heart Arrest Finally, we predicted that Lcorl-miR-200a-3p-Ttr, BRD4-Ccl2 and Ep300-miR-200b-3p-Tmem72 may participate in the pathogenesis of DHCA cerebral injury. +other 34976005 hsa-mir-200b Heart Arrest Finally, we predicted that Lcorl-miR-200a-3p-Ttr, BRD4-Ccl2 and Ep300-miR-200b-3p-Tmem72 may participate in the pathogenesis of DHCA cerebral injury. +circulation_biomarker_diagnosis_ns 34975837 hsa-mir-146a Arthritis, Rheumatoid RESULTS: Serum samples from RA patients treated with TCZ exhibited reduced circulating levels of EMMPRIN/CD147, enhanced expression of circulating miR-146a-5p and miR5p, and reduced the angiogenic potential as was manifested by the lower number of tube-like structures that were formed by EaHy926 endothelial cell line. +transcription factor target 34974862 hsa-mir-214 Intestinal Neoplasms Our study aimed at studying mechanism of miR-214 packaged with lipidosome nanoparticles on prompting apoptosis of intestinal cancer through regulating p53 pathway. The effect of miR-214 packaged with lipidosome nanoparticles on proliferation and apoptosis of intestinal cancer cells and p53 pathway in intestinal cancer cells was observed. +lncRNA target 34974815 hsa-mir-497 Breast Neoplasms We further identified miR5p as a negative regulator of PAPPA, which suppressed cell proliferation, migration, invasion, and EMT in breast cancer cells. +genetics_knock down_promote 34974809 hsa-mir-518a Squamous Cell Carcinoma of Head and Neck In addition, miR-518a could inhibit spermatogenesis-associated serine-rich 2-like (SPATS2L) expression by direct interaction, and upregulation of SPATS2L abrogated the inhibitory effect of HOXA11-AS silencing or miR-518a overexpression on CDDP resistance of CDDP-resistant LSCC cells. +genetics_knock down_promote 34974806 hsa-mir-196b Keloid Knockdown of H19, overexpression of miR-196b-5p, or knockdown of SMAD5 inhibited the viability and proliferation of keloid fibroblasts and promoted apoptosis. +genetics_knock down_promote 34974791 hsa-mir-136 Colorectal Neoplasms 5p knockdown attenuated the influence of circPTK2 silence on CRC progression and chemoresistance. +genetics_knock down_suppress 34974242 hsa-mir-541 Cholangiocarcinoma CONCLUSION: CircRTN4IP1 knockdown inhibited ICC cell malignancy by miR +genetics_knock down_promote 34974169 hsa-mir-136 Carcinoma, Hepatocellular 5p overexpression-induced influences in HCC cells. +genetics_knock down_promote 34974134 hsa-mir-185 Glioma 5p inhibition reversed the anticancer effects of circPOSTN knockdown on glioma tumorigenesis, and miR +lncRNA target 34974133 hsa-mir-511 Spinal Cord Injuries 3p may be a potential therapeutic target for SCI. +genetics_knock down_suppress 34974108 hsa-mir-766 Chorea MiR5p knockdown decreased cell viability, proliferation and migration of SCs, and also reversed the effects of lnc-RMRP silencing. +transcription factor target 34973648 hsa-mir-7 Metabolic Diseases These results reveal a novel miRNA-mediated mechanism of heat treatment on the regulation of lactate metabolism production, and suggest that targeting miR5p is a probably therapeutic method to insulin dysfunction-induced metabolic diseases. +other 34973370 hsa-mir-122 Femur Head Necrosis 5p/GREM2 axis is worthy of further investigation. +exosome 34973299 hsa-mir-221 Diabetes Mellitus 3p in diabetic wound healing and may be a novel therapeutic target for diabetic foot ulcer. +lncRNA target 34973275 hsa-mir-142 Uterine Cervical Neoplasms 3p acts as a tumor-suppressive miRNA by targeting HMGA1, A2, B1, and B3 and may serve as a potential therapeutic agent in human cervical cancer. +genetics_knock down_promote 34972532 hsa-mir-671 Stomach Neoplasms CONCLUSIONS: Circ_0000620 knockdown inhibited the malignant development of GC partly through modulating the miR +other 34972164 hsa-mir-141 Prostatic Neoplasms A lot of micro-RNAs have been known in relation to prostate cancer (PCa), and we evaluate miR-21, miR-141, and miR-221 in EVs and compare them with prostate-specific antigen (PSA). The levels of miR-21 and miR-141 in EVs did not show significant changes in patients with PCa compared to the control group in this study. +other 34972164 hsa-mir-21 Prostatic Neoplasms A lot of micro-RNAs have been known in relation to prostate cancer (PCa), and we evaluate miR-21, miR-141, and miR-221 in EVs and compare them with prostate-specific antigen (PSA). The levels of miR-21 and miR-141 in EVs did not show significant changes in patients with PCa compared to the control group in this study. +circulation_biomarker_diagnosis_ns 34972164 hsa-mir-221 Prostatic Neoplasms Area under curve (AUC) between BPH and PCa for miR-221 was 0.98 (p < 0.0001), which was better than AUC for prostate-specific antigen (PSA) level in serum for the same patients. +circulation_biomarker_diagnosis_ns 34971908 hsa-mir-203a Schizophrenia In whole blood and blood-derived exosomes of 11 first episode antipsychotic naive schizophrenia patients, DJ-1 protein and mRNA demonstrated decreased DJ-1 mRNA and protein and increased miR203a-3p levels compared to healthy controls. +lncRNA target 34971743 hsa-mir-17 Hematologic Diseases In conclusion, our research suggested that benzene induces hematotoxicity via the lincRNA-p21/miRNA5p/p21 signaling which might contribute to the underlying mechanism of lincRNA-p21 in benzene-induced hematotoxicity. +circulation_biomarker_diagnosis_up 34971719 hsa-mir-19b-1 Spinal Cord Injuries 5p in SCI was identified through detecting motor function, serum inflammation, pathological damage, cell apoptosis and GFAP expression. +circulation_biomarker_diagnosis_up 34971719 hsa-mir-19b Spinal Cord Injuries 5p in SCI was identified through detecting motor function, serum inflammation, pathological damage, cell apoptosis and GFAP expression. +genetics_knock down_promote 34970865 hsa-mir-340 Myocardial Reperfusion Injury CONCLUSIONS: Knockdown of XIST up-regulates miR +transcription factor target 34970742 hsa-mir-148a Prostatic Neoplasms, Castration-Resistant METHODS: Prostate cancer-specific miR-148a, -365, -375, and -429 were analyzed in 129 urine samples collected from 100 CRPC patients before and during AA therapy via quantitative reverse transcription PCR. +lncRNA target 34970545 hsa-mir-195 Carcinoma, Hepatocellular Conclusion: LINC01572 acts as ceRNA of miR5p to restrict its inhibition of PFKFB4, thereby enhancing glycolysis and activates PI3K/AKT signaling to trigger HCC malignancy. +genetics_GWAS 34970542 hsa-mir-155 Asthma We discovered 11 crucial ceRNA regulations concerning asthma disease feature pathway and propose a potential mechanism of ceRNA regulatory SNP --> gene --> pathway --> disease feature effecting asthma pathogenesis, especially for MALAT1 (rs765499057/rs764699354/rs189435941) --> hsa-miR-155 --> IL13 (rs201185816/rs1000978586/rs202101165) --> Interleukin-4 and Interleukin-13 signaling --> inflammation/airway remodeling and MALAT1 (rs765499057/rs764699354/rs189435941) --> hsa-miR-155 --> IL17RB (rs948046241) --> Interleukin-17 signaling (airway remodeling)/Cytokine-cytokine receptor interaction (inflammation). +genetics_overexpression_promote 34970357 hsa-mir-126 Acidosis, Respiratory Enhanced expression of HMGB1 and downstream inflammation markers was blocked by the premiR-126 overexpression and optimized by antagomiR. +other 34970356 hsa-mir-138 Iris Diseases OBJECTIVE: To investigate the effects of HOX transcript antisense RNA (HOTAIR) and miR-138 on inflammatory response and oxidative stress (OS) induced by IRI in rat cardiomyocytes. +lncRNA target 34970356 hsa-mir-138 Opitz GBBB Syndrome, X-Linked OBJECTIVE: To investigate the effects of HOX transcript antisense RNA (HOTAIR) and miR-138 on inflammatory response and oxidative stress (OS) induced by IRI in rat cardiomyocytes. CONCLUSIONS: Silent HOTAIR can promote the expression of miR-138 and inhibit H/R-induced inflammatory response and OS by regulating the NF-kappaB pathway, thus protecting cardiomyocytes. +other 34970354 hsa-mir-603 Inflammatory Bowel Diseases Taken together, the results of the present study suggest that NEAT1 contributes to the development of UC by regulating the miR-603/FGF9 pathway. +other 34970350 hsa-mir-27b Osteoporosis However, the mechanism underlying miR-27b in osteoporosis remains to be elucidated. +other 34969953 hsa-mir-24 Schizophrenia 3p/NOS3. +other 34969953 hsa-mir-335 Schizophrenia 3p/NOS3. +other 34969953 hsa-mir-34a Schizophrenia 3p/NOS3. +other 34969953 hsa-mir-7 Schizophrenia 3p/NOS3. +genetics_overexpression_promote 34969362 hsa-mir-185 Late Onset Disorders FGR foetuses overexpress miR +genetics_overexpression_promote 34969362 hsa-mir-185 Growth Disorders FGR foetuses overexpress miR +lncRNA target 34969361 hsa-mir-10a Stomach Neoplasms In summary, miR-10a-5p from GC cells-derived exo enhances viability and migration of HUVECs by suppressing ZMYND11. +genetics_knock down_promote 34969360 hsa-mir-495 Colorectal Neoplasms Thus, the current data highlight that NORAD knockdown may antagonize hypoxia-triggered CRC malignancy by suppressing VM formation and chemoresistance by sponging miR +genetics_knock down_promote 34969359 hsa-mir-132 Retinoblastoma 3p knockdown on RB cells. +other 34969357 hsa-mir-647 Carcinoma, Hepatocellular However, the regulatory mechanisms mediated by miR-647 involved in HCC remain unclear. Hence, to clarify the regulatory mechanisms mediated by miR-647 in HCC, we studied the independent effects of miR-647 and explored protein tyrosine phosphatase receptor type F (PTPRF) in the constructed HCC cell line (HCV-huh7.5). +circulation_biomarker_diagnosis_ns 34969354 hsa-mir-134 Diabetes, Gestational 5p was increased in the serum of GDM patients and could serve as a critical diagnostic marker for GDM. +circulation_biomarker_diagnosis_ns 34969353 hsa-mir-132 Epilepsy Plasma miR-146a and miR-132 expressions increased in epileptic patients, and miR-132 expression reflected the severity of epilepsy and predicted the risks of complications. +circulation_biomarker_diagnosis_ns 34969353 hsa-mir-146a Epilepsy Plasma miR-146a and miR-132 expressions increased in epileptic patients, and miR-132 expression reflected the severity of epilepsy and predicted the risks of complications. +genetics_GWAS 34969167 hsa-mir-149 Mucocutaneous Lymph Node Syndrome CONCLUSIONS: Our results demonstrated that the miR-149 rs2292832 T>C polymorphism increased the risk of CAA in KD patients and that the miR-499a rs3746444 A>G polymorphism decreased the risk of CAA in KD patients. +genetics_GWAS 34969167 hsa-mir-196a-2 Mucocutaneous Lymph Node Syndrome The present study further focused on the relationship between three miRNA polymorphisms (miR-149 rs2292832 T>C, miR-196a2 rs11614913 C>T and miR-499a rs3746444 A>G) and the risk of coronary artery aneurysm (CAA) in southern Chinese KD patients. +genetics_GWAS 34969167 hsa-mir-499a Mucocutaneous Lymph Node Syndrome CONCLUSIONS: Our results demonstrated that the miR-149 rs2292832 T>C polymorphism increased the risk of CAA in KD patients and that the miR-499a rs3746444 A>G polymorphism decreased the risk of CAA in KD patients. +other 34968919 hsa-mir-30 Osteosarcoma 3p exhibits pro-tumorigenesis effects in lung cancer, pancreatic cancer, osteosarcoma, bladder cancer, and cervical cancer. +other 34968919 hsa-mir-30 Carcinoma, Hepatocellular Dual roles of miR5p have been also indicated in the thyroid, liver and cervical cancers. +other 34968919 hsa-mir-30 Urinary Bladder Neoplasms Moreover, miR3p exhibits pro-tumorigenesis effects in lung cancer, pancreatic cancer, osteosarcoma, bladder cancer, and cervical cancer. +other 34968919 hsa-mir-30 Pancreatic Carcinoma 3p exhibits pro-tumorigenesis effects in lung cancer, pancreatic cancer, osteosarcoma, bladder cancer, and cervical cancer. +other 34968919 hsa-mir-30 hereditary diffuse gastric cancer In many cancer types (such as lung, prostate, gastric, breast, bladder, ovarian, colorectal, and pancreatic cancer, and osteosarcoma), miR5p acts as an anti-tumor agent. +other 34968919 hsa-mir-30 Lung Neoplasms Moreover, miR3p exhibits pro-tumorigenesis effects in lung cancer, pancreatic cancer, osteosarcoma, bladder cancer, and cervical cancer. +other 34968919 hsa-mir-30 Uterine Cervical Neoplasms 3p exhibits pro-tumorigenesis effects in lung cancer, pancreatic cancer, osteosarcoma, bladder cancer, and cervical cancer. +other 34968919 hsa-mir-30 Breast Neoplasms Demonstrated in breast and liver cancers, miR3p also has dual roles. +other 34968855 hsa-mir-10b Breast Neoplasms Herein, a cotton thread-based multi-channel photothermal biosensor was proposed for simultaneous detection of three breast cancer-related miRNAs including miRNA-10b, miRNA-27a and miRNA-let-7a. +other 34968855 hsa-mir-27a Breast Neoplasms Herein, a cotton thread-based multi-channel photothermal biosensor was proposed for simultaneous detection of three breast cancer-related miRNAs including miRNA-10b, miRNA-27a and miRNA-let-7a. +genetics_knock down_promote 34968780 hsa-mir-524 Chondrosarcoma Mechanistically, although knockdown of YAP upregulated both the nuclear and cytoplasmic TXNIP expression, we did not observe any obvious interaction between YAP and TXNIP; instead, miRNA +other 34968461 hsa-mir-133a Myocardial Reperfusion Injury The expression of MALAT1, miR-133a-3p in MIRI were evaluated using real-time quantitative polymerase chain reaction (qRT-PCR)immunohistochemistry (IHC) and western blot (WB). In summary, these results suggest that MALAT1 and miR-133a-3p play important roles in MIRI. +other 34968168 hsa-mir-1-1 Intrauterine Adhesion Crucial lncRNAs such as ADIRF-AS1, LINC00632, DIO3OS, MBNL1-AS1, MIR1-1HG-AS1, AC100803.2 was involved in the development of IUA. +genetics_overexpression_promote 34968167 hsa-mir-128 Stomach Neoplasms In addition, GC cells were cocultured with T lymphocytes, and the subsequent flow cytometric analysis showed that overexpression of miR +genetics_overexpression_promote 34968160 hsa-mir-20b Carcinoma, Non-Small-Cell Lung Overall, miR-20b-5p overexpression combined with Pembrolizumab potentiated cancer cells' sensitivity to RT by repressing PD-L1/PD1.Abbreviations Akt: serine/threonine kinase 1; cDNA: complementary DNA; CO(2): carbon dioxide; EDTA: Ethylene Diamine Tetraacetic Acid; ENCORI: The Encyclopedia of RNA Interactomes; GAPDH: glyceraldehyde +genetics_overexpression_promote 34968160 hsa-mir-20b Small Cell Lung Carcinoma Overall, miR-20b-5p overexpression combined with Pembrolizumab potentiated cancer cells' sensitivity to RT by repressing PD-L1/PD1.Abbreviations Akt: serine/threonine kinase 1; cDNA: complementary DNA; CO(2): carbon dioxide; EDTA: Ethylene Diamine Tetraacetic Acid; ENCORI: The Encyclopedia of RNA Interactomes; GAPDH: glyceraldehyde +lncRNA target 34967761 hsa-mir-141 Endometriosis 5p are possible biomarkers and therapeutic targets for endometriosis. +lncRNA target 34967707 hsa-let-7c Lung Neoplasms DISCUSSION AND CONCLUSION: CuB regulated cell proliferation and apoptosis by inhibiting the XIST/miR-let-7c/IL-6/STAT3 axis in lung cancer. +lncRNA target 34967706 hsa-mir-221 Parkinson Disease LncRNA MIAT promoted MPP(+)-induced neuronal injury in PD via regulating TGF-beta1/Nrf2 axis through binding with miR3p. +lncRNA target 34967706 hsa-mir-221 Epilepsy LncRNA MIAT promoted MPP(+)-induced neuronal injury in PD via regulating TGF-beta1/Nrf2 axis through binding with miR3p. +lncRNA target 34967697 hsa-mir-1277 Neuroblastoma These data suggest that SNHG10 regulates IRS2 through interacting with miR +lncRNA target 34967592 hsa-mir-21 Nasopharyngeal Carcinoma The abnormal expression of miR-21 has been proven to be associated with various types of cancers, including NPC, through its targets. +other 34967587 hsa-mir-145 Colorectal Neoplasms 5p and NRAS can be utilized as diagnostic biomarkers in colorectal cancer death. +circRNA target 34967281 hsa-mir-486 Squamous Cell Carcinoma of Head and Neck Moreover, the inhibitory effects of circ_0005320 silencing on OSCC growth were reversed by the inhibition of miR +circRNA target 34967281 hsa-mir-637 Squamous Cell Carcinoma of Head and Neck Moreover, the inhibitory effects of circ_0005320 silencing on OSCC growth were reversed by the inhibition of miR +lncRNA target 34967274 hsa-mir-582 Colorectal Neoplasms Collectively, our data suggest that lncRNA DCST1-AS1 regulates the aggressiveness of CRC cells through hsa-miR +lncRNA target 34967266 hsa-mir-19a Polycystic Ovary Syndrome MicorRNA-19a (miR-19a) is a well-characterized miRNA in cancer biology and its function is mainly mediated by targeting tumor necrosis factor alpha (TNF-alpha), which plays critical roles in PCOS. Therefore, PLAC2 may regulate miR-19a/TNF-alpha to participate in PCOS. +transcription factor target 34967265 hsa-mir-21 Breast Neoplasms 5p inhibitor with reversine produced a synergistic effect by regulating SPRY2, thereby limiting HBC progression. +lncRNA target 34967264 hsa-mir-186 Osteochondritis Dissecans Moreover, miR5p inhibition or YY1 upregulation abolished the effects of SOX2-OT blocking on the inflammatory responses, proliferation, and apoptosis of OGD/R-challenged H2C9 cells. +lncRNA target 34967264 hsa-mir-186 Myocardial Reperfusion Injury In conclusion, our results, for the first time, demonstrated that SOX2-OT inhibition attenuated MI/R injury in vitro via regulating the miR5p/YY1 axis, offering potential therapeutic targets for MI/R injury treatment. +other 34966905 hsa-mir-122 Liver Injury In addition, microRNA-122 is sensitive for early detection of liver injury in acetaminophen overdose patients. +genetics_overexpression_suppress 34966644 hsa-mir-7 Cholangiocarcinoma Overexpression of MyD88 counteracted the effects of miR +circulation_biomarker_prognosis_up 34966454 hsa-mir-103a Breast Neoplasms The circulating serum miR-103a-3p level could be used to discriminate between patients with BC and the healthy controls prior to surgery using an area under curve [(AUC), 0.697; 95% confidence intervals (CI), 0.615-0.778], and distinguish patients with BC and metastasis from those without metastasis (AUC, 0.936; 95% CI, 0.892-0.980). +genetics_overexpression_promote 34966442 hsa-mir-429 Osteochondritis Dissecans The results showed that miR-429 was significantly upregulated in the serums of the patients, and overexpressed miR-429 could extremely inhibit the viability, migration, and tube formation of OGD-induced HBMECs. +genetics_overexpression_promote 34966429 hsa-mir-23b Colonic Neoplasms Furthermore, miR-23b-3p overexpression hindered the growth of COAD cells in vivo. +genetics_overexpression_promote 34965835 hsa-mir-128 Heart Failure Adeno-associated virus serotype 9 (AAV9)-mediated constructs with miR-128 or anti-miR-128 were generated and delivered to overexpression or blockade of miR-128 in vivo followed by HF induction with isoproterenol (ISO) or transverse aortic constriction (TAC). +other 34965618 hsa-mir-146a Periodontal Diseases Most studies reported higher expression levels of miR-146a in patients with periodontitis than in healthy controls. +circulation_biomarker_diagnosis_up 34965271 hsa-mir-210 Acquired Immunodeficiency Syndrome inoculated cell lines and in the serum of HIV +genetics_knock down_promote 34965215 hsa-mir-454 Nasopharyngeal Carcinoma 3p, is downregulated by LINC00839 knockdown in NPC cells. +lncRNA target 34965191 hsa-mir-653 Colonic Neoplasms 3p, partially offset the inhibitory effect of miR +other 34965090 hsa-mir-155 Triple Negative Breast Neoplasms As a result, the polarization-resolved ECL sensor can detect miRNA-155 sensitively, which is related to triple-negative breast cancer. +other 34965027 hsa-mir-148a Osteoarthritis CMEVs are carriers of both TGFbeta and miR-148a, two essential regulators for maintaining chondrocyte homeostasis and protection against cartilage destruction. +lncRNA target 34964438 hsa-mir-20b Non-alcoholic Fatty Liver Disease CONCLUSIONS: Taken together, our results demonstrate that the novel MIR20B targets PPARA, plays a significant role in hepatic lipid metabolism, and present an opportunity for the development of novel therapeutics for NAFLD. +circulation_biomarker_diagnosis_ns 34964177 hsa-mir-29a Diabetic Nephropathies CONCLUSION: The expression of serum miR-29a was significantly associated with the occurrence and progression of DN and is expected to become a potential biomarker for the diagnosis of DN. +lncRNA target 34963484 hsa-mir-423 Diabetic Retinopathy 5p transcription during DR to promote angiogenesis via suppressing HIPK2 expression to disinhibit HIF1alpha/VEGF signaling. +circulation_biomarker_diagnosis_up 34963442 hsa-mir-1825 Colorectal Neoplasms Two important upregulated miRNAs, namely hsa-miR-1246 and hsamiR- 1825, were overlapped in both tissue and serum samples of CRC and were investigated to target identification, followed by functional annotation and protein-protein interaction (PPI) study for the target genes through DAVID and STRING, respectively. CONCLUSION: This study suggested that hsa-miR-1246 and hsa-miR-1825, as overlapped upregulated tissue and circulating miRNAs, might have a vital role in the development of CRC, and their five hub target genes were identified. +circulation_biomarker_diagnosis_up 34963442 hsa-mir-1246 Colorectal Neoplasms Two important upregulated miRNAs, namely hsa-miR-1246 and hsamiR- 1825, were overlapped in both tissue and serum samples of CRC and were investigated to target identification, followed by functional annotation and protein-protein interaction (PPI) study for the target genes through DAVID and STRING, respectively. CONCLUSION: This study suggested that hsa-miR-1246 and hsa-miR-1825, as overlapped upregulated tissue and circulating miRNAs, might have a vital role in the development of CRC, and their five hub target genes were identified. +circulation_biomarker_diagnosis_ns 34963440 hsa-mir-20a Pre-Eclampsia This study shows for the first time the presence of miR-20a, miR-199, and miR-424 and the variations they undergo in the plasma of pregnant women with preeclampsia. +circulation_biomarker_diagnosis_ns 34963440 hsa-mir-424 Pre-Eclampsia This study shows for the first time the presence of miR-20a, miR-199, and miR-424 and the variations they undergo in the plasma of pregnant women with preeclampsia. +circulation_biomarker_diagnosis_ns 34963440 hsa-mir-26a Pre-Eclampsia METHOD: Nine placental microRNAs (hsa-miR- 20a-5p, 21-3p, 26a-5p, 181a-5p, 199a-5p, 210-3p, 222-5p, 223-3p, 424-3p) were measured in maternal plasma during the second and third trimesters of normal pregnancies, using a SYBR Green-based real-time PCR, and compared the results against women affected by preeclampsia. +circulation_biomarker_diagnosis_ns 34963440 hsa-mir-199a Pre-Eclampsia This study shows for the first time the presence of miR-20a, miR-199, and miR-424 and the variations they undergo in the plasma of pregnant women with preeclampsia. +circulation_biomarker_diagnosis_ns 34963440 hsa-mir-21 Pre-Eclampsia METHOD: Nine placental microRNAs (hsa-miR- 20a-5p, 21-3p, 26a-5p, 181a-5p, 199a-5p, 210-3p, 222-5p, 223-3p, 424-3p) were measured in maternal plasma during the second and third trimesters of normal pregnancies, using a SYBR Green-based real-time PCR, and compared the results against women affected by preeclampsia. +genetics_knock down_promote 34963405 hsa-mir-1236 Retinoblastoma 3p overexpression suppressed RB cell progression, with SMAD2 elevation abrogated the effect. +transcription factor target 34962394 hsa-mir-15b Colitis Most significantly, sweeteners can enhance the abundance of Mucispirillum and Alistipes, which are conducive to colitis recovery, and upregulate the expression of E-cadherin through the miR-15b/RECK/MMP-9 axis to improve intestinal barrier integrity. +lncRNA target 34962339 hsa-mir-210 Diabetic Retinopathy This investigation aimed to determine whether gingerol plays a neuroprotective role in cerebral ischemia via the miR-210/BDNF axis. +target gene 34962153 hsa-mir-29a Colorectal Neoplasms Ginkgo biloba Extract Inhibited Cell Proliferation and Invasion by Stimulating TET2 Expression Through miR-29a in Colorectal Carcinoma Cells. +genetics_overexpression_promote 34962143 hsa-mir-28 Dry Eye Syndromes Conclusion: Overexpression of miR-328 may contribute to DED. +lncRNA target 34962086 hsa-mir-124 Osteoporosis In conclusion, lncRNA MALAT1 promoted the osteogenic differentiation of BMSCs and inhibited osteoclastic differentiation of M in osteoporosis via the miR3p/IGF2BP1/Wnt/-catenin axis. +other 34961772 hsa-mir-21 Breast Neoplasms Among these miRNAs, miR-21 is known for its transcriptional upregulation in breast and numerous other cancers. +circRNA target 34961410 hsa-mir-377 Capsule Opacification CONCLUSION: These results showed that circ-MKLN1 contributed to the progression of PCO in vitro by increasing the CTGF expression via sponging miR3p. +other 34961041 hsa-mir-99 Starvation Here, we exposed Arabidopsis thaliana (Arabidopsis) transformant lines which harbor molecular modifications to the miR396 and miR399 expression modules to phosphate (PO(4)) starvation. We show that molecular alteration of either miR396 or miR399 abundance afforded the Arabidopsis transformant lines different degrees of tolerance to PO(4) starvation. +other 34961041 hsa-mir-96 Starvation Here, we exposed Arabidopsis thaliana (Arabidopsis) transformant lines which harbor molecular modifications to the miR396 and miR399 expression modules to phosphate (PO(4)) starvation. We show that molecular alteration of either miR396 or miR399 abundance afforded the Arabidopsis transformant lines different degrees of tolerance to PO(4) starvation. +circulation_biomarker_diagnosis_ns 34959623 hsa-mir-145 Spermatic Cord Torsion The biochemical analysis indicated that IR injury following T/D significantly decreased the activity of testicular glutathione peroxidase (GPx) enzyme, level of serum testosterone, serum inhibin B, and expression of testicular miRNA145, while increased the activity of testicular myeloperoxidase (MPO) enzyme, level of testicular malondialdehyde (MDA), level of serum antisperm-antibody (AsAb), and expression of ADAM-17. In conclusion, this study highlights the protective pharmacological application of vitamin D3 to ameliorate the damages of testicular T/D on the testicular tissues via targeting miRNA145 and ADAM17 protein. +exosome 34958869 hsa-mir-106a Stomach Neoplasms Tissue analysis verified the ectopic miR-106a expression in gastric cancer metastasis. CONCLUSION: Our data suggest that exosomal miR-106a facilitates gastric cancer peritoneal dissemination by integrating PMC to destroy mesothelial barrier. +lncRNA target 34958454 hsa-mir-137 Colonic Neoplasms inhibited glutamine metabolism. +other 34958294 hsa-mir-17 Neointimal Hyperplasia 5p vs. +genetics_overexpression_promote 34958117 hsa-mir-485 Prostatic Neoplasms 3p overexpression suppressed the activity of TGF- signaling by targeting TGFBR2 to play tumor-suppressive roles in PC progression. +other 34958006 hsa-mir-335 Colorectal Neoplasms Association of miR-21 and miR-335 to microsatellite instability and prognosis in BACKGROUND: MicroRNAs (miRs) are frequently altered in colorectal cancer (CRC) and can be used as prognostic factors. +other 34958006 hsa-mir-21 Colorectal Neoplasms Association of miR-21 and miR-335 to microsatellite instability and prognosis in BACKGROUND: MicroRNAs (miRs) are frequently altered in colorectal cancer (CRC) and can be used as prognostic factors. +transcription factor target 34957997 hsa-mir-142 Carcinoma, Non-Small-Cell Lung 5p and its target Ulk1. +other 34957995 hsa-mir-767 Carcinoma, Non-Small-Cell Lung 3p as a sponge. +genetics_knock down_suppress 34957935 hsa-mir-494 Precursor Cell Lymphoblastic Leukemia-Lymphoma 3p overexpression-induced anti-tumor influences were partly counteracted by the accumulation of NET1 in ALL cells. +lncRNA target 34957910 hsa-mir-21 Atrial Fibrillation This showed that microRNA-1 and microRNA-21 were involved in the molecular remodeling of aging AF through the regulation of primers, which would provide a critical basis for diagnosis and treatment of aging AF. +lncRNA target 34957910 hsa-mir-1 Atrial Fibrillation This showed that microRNA-1 and microRNA-21 were involved in the molecular remodeling of aging AF through the regulation of primers, which would provide a critical basis for diagnosis and treatment of aging AF. +circulation_biomarker_diagnosis_ns 34957382 hsa-mir-451a COVID-19 Analysis of an independent cohort of 108 patients from a different center (Cohort 2) demonstrated feasibility of CC/miRNA profiling in leftover hospital blood samples with similar severe disease CC and miRNA profiles, and revealed CCL20, IL6, IL10, and miR-451a as key correlates of fatal COVID-19. +genetics_overexpression_promote 34957298 hsa-mir-149 Stomach Neoplasms RESULTS: miRNA-149 was underexpressed in gastric cancer tissues and cells, while overexpression of miRNA-149 promoted cell apoptosis, retarded cell cycle, and inhibited proliferation and migration in AGS and MKN28 cells. +other 34957214 hsa-mir-21 Incontinentia Pigmenti In this study, we examined the expression levels of two human miRNAs (miRNA-122 and miRNA-21) in stool samples of a group of Bangladeshi children who had an altered/increased intestinal permeability (IIP). Results: The expression levels of miRNA-122 (fold change 11.6; p < 0.001, 95% CI: 6.14-11.01) and miR-21 (fold change 10; p < 0.001, 95% CI: 5.05-10.78) in stool were upregulated in children with IIP than in children with normal intestinal permeability (NIP). +other 34957214 hsa-mir-122 Incontinentia Pigmenti In this study, we examined the expression levels of two human miRNAs (miRNA-122 and miRNA-21) in stool samples of a group of Bangladeshi children who had an altered/increased intestinal permeability (IIP). Results: The expression levels of miRNA-122 (fold change 11.6; p < 0.001, 95% CI: 6.14-11.01) and miR-21 (fold change 10; p < 0.001, 95% CI: 5.05-10.78) in stool were upregulated in children with IIP than in children with normal intestinal permeability (NIP). +genetics_knock down_promote 34957102 hsa-mir-940 Colorectal Neoplasms Circ_0062682 knockdown suppressed CRC growth by decreasing PHGDH expression and serine production via miR-940. +epigenetics 34957096 hsa-mir-760 Osteosarcoma Conclusion: Methylated DEGs may be involved in the development of OS, and the hsa_circ_0001753/has_miR_760/CD74 network may serve as a target for the early diagnosis of and targeted therapy for OS. +other 34956895 hsa-mir-410 Breast Neoplasms The LINC00665-miR3p axis was identified as the most potential upstream ncRNA-related pathway of EMC2 in breast cancer. +target gene 34956884 hsa-mir-616 Urinary Bladder Neoplasms miR-616-5p Promotes Invasion and Migration of Bladder Cancer via Downregulating NR2C2 Expression. +genetics_overexpression_promote 34956562 hsa-mir-141 Thyroid Neoplasms Overexpression of BRD4 can partially reverse the restraining effect of miR +other 34956559 hsa-mir-29c Alzheimer Disease MiR-29c-3p has specific binding sites with the 3'-untranslated region (3'-UTR) of BACE1 and thus negatively regulates the BACE1 level, thereby affecting the progression of AD. +circulation_biomarker_diagnosis_up 34956523 hsa-mir-451 Infertility Compared with normal people, miR-451 was abnormally low in endometriosis complicated with infertility tissues and cell lines (P<0.001), while MIF was abnormally high (P<0.001), and the miR-451 expression was dramatically down-regulated and the MIF expression was markedly up-regulated in serum of endometriosis patients complicated with infertility. +circulation_biomarker_diagnosis_up 34956523 hsa-mir-451 Endometriosis Compared with normal people, miR-451 was abnormally low in endometriosis complicated with infertility tissues and cell lines (P<0.001), while MIF was abnormally high (P<0.001), and the miR-451 expression was dramatically down-regulated and the MIF expression was markedly up-regulated in serum of endometriosis patients complicated with infertility. +target gene 34956484 hsa-mir-103a Carcinoma, Renal Cell MiR-103a-3p aggravates renal cell carcinoma by targeting TMEM33. +lncRNA target 34956482 hsa-mir-199a Urinary Bladder Neoplasms Down-regulating linc00662 cinduced the expression of miR-199a-5p in BC and suppressed tumor growth. +circulation_biomarker_diagnosis_ns 34956481 hsa-mir-200a Enterocolitis, Necrotizing METHOD: The differentially expressed miRs in NEC were screened by analyzing GSE68054, and miR-200a-3p in IEC-6 cells induced by lipopolysaccharide (LPS) and serum of NEC children were detected by qRT-PCR. +other 34956462 hsa-mir-335 Meniscus Degeneration RESULTS: We found that MUC13, inflammatory mediator regulation of TRP channels, MDFI, and miR5p may play a key role in the degenerative meniscus tissue. +genetics_GWAS 34956454 hsa-mir-433 Carcinoma, Non-Small-Cell Lung The epigenetic silencing of microRNA-433 facilitates the malignant phenotypes of non-small cell lung cancer by targeting CREB1. +lncRNA target 34956453 hsa-mir-154 Osteosarcoma Finally, rescue experiments determined that KCNQ1OT1 exerted major roles in OS through the miR +genetics_knock down_promote 34956421 hsa-mir-19b Myocardial Infarction Knockdown of miRNA-19b-3p decreased activities of LDH, MDA, and GSH-PX, but increased SOD level in H/R-induced HCM cells. +genetics_overexpression_promote 34956398 hsa-mir-381 Glioma In this work, we confirmed that overexpressed miR +circulation_biomarker_diagnosis_ns 34956389 hsa-mir-19b Infertility In addition, the expression of miRNAs, miR-328, miR-34, and miR-19b, in KP-treated and nontreated infertile rats significantly correlated with increased serum testosterone levels and epididymal sperm parameters as well. +circulation_biomarker_diagnosis_ns 34956389 hsa-mir-28 Infertility In addition, the expression of miRNAs, miR-328, miR-34, and miR-19b, in KP-treated and nontreated infertile rats significantly correlated with increased serum testosterone levels and epididymal sperm parameters as well. +other 34956389 hsa-mir-28 Infertility, Male The respective area under the receiver operating characteristic curve (AUC-ROC) was applied to predict the potential use of miR-328, miR-19b, and miR-34 in the diagnosis of male infertility in treated and nontreated infertile male rats. +circulation_biomarker_diagnosis_ns 34956389 hsa-mir-34 Infertility In addition, the expression of miRNAs, miR-328, miR-34, and miR-19b, in KP-treated and nontreated infertile rats significantly correlated with increased serum testosterone levels and epididymal sperm parameters as well. +other 34956389 hsa-mir-34 Infertility, Male The respective area under the receiver operating characteristic curve (AUC-ROC) was applied to predict the potential use of miR-328, miR-19b, and miR-34 in the diagnosis of male infertility in treated and nontreated infertile male rats. +other 34956389 hsa-mir-19b Infertility, Male The respective area under the receiver operating characteristic curve (AUC-ROC) was applied to predict the potential use of miR-328, miR-19b, and miR-34 in the diagnosis of male infertility in treated and nontreated infertile male rats. +other 34956365 hsa-mir-517c Glioma High levels of miR-296 and miR-517c can enhance chemosensitivity and serve as reliable indexes to predict the prognosis of patients with glioma. +transcription factor target 34956364 hsa-mir-137 Nasopharyngeal Neoplasms In conclusion, our findings showed that miR-137 acted as a tumor suppressor gene in controlling NPC EMT and metastasis and that it may be a new therapeutic strategy and prognosis marker for the disease. +lncRNA target 34956213 hsa-mir-146a COVID-19 Toll-like receptor 4 (TLR4) was inhibited in COVID-19 pneumonia by miR-146a-5p and upregulated in ARDS by let-7e-5p. +lncRNA target 34956213 hsa-let-7e COVID-19 Toll-like receptor 4 (TLR4) was inhibited in COVID-19 pneumonia by miR-146a-5p and upregulated in ARDS by let-7e-5p. +genetics_overexpression_promote 34956209 hsa-mir-122 Osteoarthritis In summary, our results suggest that IDO1 overexpression in the synovial fluid of OA patients impairs chondrogenic differentiation of MSCs and cartilage regeneration through downregulation of miR5p that activates the Wnt1/beta-catenin pathway. +other 34956196 hsa-mir-197 Multiple Sclerosis To our knowledge, this would be the first report of a possible role of SNHG1/hsa-miR3p/YOD1/ZNF101 axes in the pathogenesis of MS. +circulation_biomarker_diagnosis_ns 34955881 hsa-mir-423 Bicuspid Aortic Valve Disease CONCLUSION: Plasma exosomal miR5p regulated TGF-beta signaling by targeting SMAD2, thus exerting functions in the occurrence and development of BAV disease and its complication bicuspid aortopathy. +transcription factor target 34955743 hsa-mir-101 late onset Parkinson's disease These results suggest that miR-101 regulates SEL1L expression and may serve as a new target for PD therapy. +lncRNA target 34955656 hsa-mir-3677 Adenocarcinoma of Lung 3p can promote LUAD progression by targeting KLF12. +circulation_biomarker_diagnosis_ns 34955516 hsa-let-7g Alzheimer Disease Previous evidence shows that miR-15b-5p, hsa-let7g-5p and hsa-let7d-5p might confer potential blood biomarkers for timely diagnosis of AD. +circulation_biomarker_diagnosis_ns 34955516 hsa-mir-15b Alzheimer Disease Evaluation of hsa-let-7d-5p, hsa-let-7g-5p and hsa-miR-15b-5p plasma levels in BACKGROUND: Alzheimer's disease (AD) is a progressive neurodegenerative disorder MicroRNAs (miRNAs) may be promising diagnostic biomarkers for AD. +circulation_biomarker_diagnosis_ns 34955516 hsa-let-7d Alzheimer Disease Previous evidence shows that miR-15b-5p, hsa-let7g-5p and hsa-let7d-5p might confer potential blood biomarkers for timely diagnosis of AD. +other 34955008 hsa-let-7 Adenomyosis OBJECTIVE: To evaluate the possibility of using microrna let-7 and mir-9 as non-invasive biomarkers for the diagnosis and treatment of external genital endometriosis. +other 34955008 hsa-let-7 Endometriosis In addition, a significant difference was noted regarding let-7 microRNA between the groups with and without endometriosis, as well as between the groups with more clinically and histologically severe and mild endometriosis. +other 34955008 hsa-mir-9 Endometriosis OBJECTIVE: To evaluate the possibility of using microrna let-7 and mir-9 as non-invasive biomarkers for the diagnosis and treatment of external genital endometriosis. RESULTS: Mann-Whitney analysis showed that the difference in mir-9 mRNA between the groups with and without endometriosis, as well as between the groups with more clinically and histologically severe and mild endometriosis, was statistically insignificant. +other 34955008 hsa-mir-9 Adenomyosis OBJECTIVE: To evaluate the possibility of using microrna let-7 and mir-9 as non-invasive biomarkers for the diagnosis and treatment of external genital endometriosis. +other 34954928 hsa-mir-623 Carcinoma, Hepatocellular DISCUSSIONS: Our study demonstrated main role of miR-515, miR-623 and miR-1272 in HCC pathogenesis and similarly disclosed that these genes expression could be utilized in HCC prognosis. +other 34954928 hsa-mir-1272 Carcinoma, Hepatocellular DISCUSSIONS: Our study demonstrated main role of miR-515, miR-623 and miR-1272 in HCC pathogenesis and similarly disclosed that these genes expression could be utilized in HCC prognosis. +other 34954928 hsa-mir-515 Carcinoma, Hepatocellular DISCUSSIONS: Our study demonstrated main role of miR-515, miR-623 and miR-1272 in HCC pathogenesis and similarly disclosed that these genes expression could be utilized in HCC prognosis. +lncRNA target 34954927 hsa-mir-15a Glioma In addition, the luciferase activity of FAM66C was block by miR15a/miR15b, and the promotion of cell growth effects caused by FAM66C deficiency was attenuated by miR15a/miR15b mimics, further proved that FAM66C functioned as a competing endogenous RNA to regulate glioma growth via the miRNA/LATS1 signaling pathway. +lncRNA target 34954927 hsa-mir-15b Glioma In addition, the luciferase activity of FAM66C was block by miR15a/miR15b, and the promotion of cell growth effects caused by FAM66C deficiency was attenuated by miR15a/miR15b mimics, further proved that FAM66C functioned as a competing endogenous RNA to regulate glioma growth via the miRNA/LATS1 signaling pathway. +genetics_overexpression_promote 34954748 hsa-mir-181b Angelman Syndrome Circ_0002984 and VEGFA were overexpressed, and miR-181b-5p was downregulated in serum of AS patients and ox-LDL-stimulated VSMCs. Circ_0002984 downregulation suppressed cell proliferation and migration by regulating miR-181b-5p/VEGFA axis and phosphatidylinositol 3 kinase-AKT pathway in ox-LDL-stimulated VEGFA, providing a new mechanism for AS pathogenesis. +genetics_knock down_promote 34954694 hsa-mir-545 Colorectal Neoplasms We found that TF overexpression blocked miR +other 34954656 hsa-mir-223 Periodontal Diseases Additionally, inflammation-associated miR-21, miR3p, miR-223, and miR-125a-5p showed significantly higher expression in the gingiva of VEH/SIV RMs. +other 34954656 hsa-mir-142 Periodontal Diseases Additionally, inflammation-associated miR-21, miR3p, miR-223, and miR-125a-5p showed significantly higher expression in the gingiva of VEH/SIV RMs. +other 34954656 hsa-mir-125a Periodontal Diseases Additionally, inflammation-associated miR-21, miR3p, miR-223, and miR-125a-5p showed significantly higher expression in the gingiva of VEH/SIV RMs. +genetics_GWAS 34954153 hsa-mir-4440 Breast Neoplasms CONCLUSION: CDKN2B-AS1 gene polymorphism might be related to the susceptibility of BC, CDKN2B-AS1 rs10965215 A/G genotype probably affect the proliferation, invasion and migration of BC cells by modulating the interactions with of miR-4440. +genetics_knock down_suppress 34953943 hsa-mir-29c Inflammation When the MIAT-specific short hairpin RNA and an miR-29c-3p inhibitor were cotransfected into cells, the inhibitor reversed the effects of MIAT knockdown on cell proliferation, apoptosis, inflammation, EMT, and collagen deposition. +other 34953943 hsa-mir-29c Pulmonary Disease, Chronic Obstructive Overall, these results indicate that MIAT participates in CS-induced EMT and airway remodeling in COPD by upregulating miR-29c-3p-HIF3A axis output, thereby offering a novel promising biomarker for the assessment of COPD exacerbation induced by CS exposure. +circulation_biomarker_diagnosis_up 34953918 hsa-mir-335 Esophageal Squamous Cell Carcinoma RESULTS: Our expression studies showed a significantly decreased expression of tissue and circulating miR +transcription factor target 34953498 hsa-mir-216a Stomach Neoplasms miR-216a-5p was identified as a critical suppressor of FDFT1 expression and miR-216a-5p/FDFT1 axis regulated malignant behaviors and glycolysis of GC cells. GS suppressed malignant behaviors of GC by targeting miR-216a-5p/FDFT1 axis both in vitro and in vivo. +lncRNA target 34953475 hsa-mir-182 Nasal Polyps induced EMT in response to TGF-beta1 might promote nasal polypogenesis in both Eos CRSwNP and non-Eos CRSwNP, thus providing potential targets for the future development of novel therapeutic approaches for the management of CRSwNP. +lncRNA target 34953475 hsa-mir-182 Nasopharyngitis induced EMT in response to TGF-beta1 might promote nasal polypogenesis in both Eos CRSwNP and non-Eos CRSwNP, thus providing potential targets for the future development of novel therapeutic approaches for the management of CRSwNP. +genetics_GWAS 34953275 hsa-mir-6769b Fetal Growth Retardation Our findings imply that placental miR-6769b-5p may be used as an epigenetic marker for environmental pollutants-caused fetal growth restriction and its late-onset chronic diseases. +genetics_knock down_promote 34953057 hsa-mir-192 Lung Neoplasms In vitro loss- and gain-of-function studies were performed to reveal the biological function of miR-192 and related mechanism of the microRNA-192/NKRF axis in lung cancer cell cisplatin resistance. +genetics_overexpression_promote 34953047 hsa-mir-223 Breast Neoplasms In addition, overexpressed miR +circulation_biomarker_diagnosis_ns 34952998 hsa-mir-146a psoriasis 1 METHODS: Plasma samples were collected from 84 moderate-to-severe psoriasis patients who underwent etanercept treatment (at baseline (M0), 1 month (M1), 3 months (M3), and 6 months (M6)), 80 disease controls and 80 health controls (both after enrollment); afterward, miR-146a and miR-146b expressions were detected by RT-qPCR. +circulation_biomarker_diagnosis_ns 34952998 hsa-mir-146b psoriasis 1 METHODS: Plasma samples were collected from 84 moderate-to-severe psoriasis patients who underwent etanercept treatment (at baseline (M0), 1 month (M1), 3 months (M3), and 6 months (M6)), 80 disease controls and 80 health controls (both after enrollment); afterward, miR-146a and miR-146b expressions were detected by RT-qPCR. +lncRNA target 34952600 hsa-mir-944 Breast Neoplasms Notably, BC patients with high expression of HNRNPC and low expression of hsa-miR-944 were correlated with late clinical stages and shorter survival times. Moreover, the circBACH2 (hsa_circ_0001625) was confirmed to act as hsa-miR-944 sponge to stimulate HNRNPC expression to promote BC cell proliferation via MAPK signaling pathway, thus constructing a circBACH2/hsa-miR-944/HNRNPC axis in BC. +exosome 34952333 hsa-mir-195 Osteosarcoma Chondrocyte-derived Exosomal miR-195 Inhibits Osteosarcoma Cell Proliferation and Anti-Apoptotic by Targeting KIF4A in vitro and in vivo. +lncRNA target 34952204 hsa-mir-142 Tongue Neoplasms 5p inhibition substantially reversed the effects of PTTG3P silencing. +circulation_biomarker_diagnosis_ns 34951996 hsa-mir-196a Nasopharyngeal Carcinoma Moreover, we demonstrate an enrichment of miR196a-5p in the plasmatic EVs of NPC patients. +genetics_knock down_promote 34951563 hsa-mir-1270 Carcinoma, Hepatocellular Contrarily, exhausting miR-1270 and restoring COL4A1 could severally abrogate the tumor-suppressive roles of circ_0088364 knockdown and miR-1270 overexpression in HCC cells in vitro. +circulation_biomarker_diagnosis_ns 34951407 hsa-mir-125b Atherosclerosis Our results suggest that circulating miR-34a, miR-125b and miR-221 levels can be used as novel biomarkers for detection of atherosclerosis by targeting NRF2. +circulation_biomarker_diagnosis_ns 34951407 hsa-mir-221 Atherosclerosis Our results suggest that circulating miR-34a, miR-125b and miR-221 levels can be used as novel biomarkers for detection of atherosclerosis by targeting NRF2. +lncRNA target 34951340 hsa-mir-181a Breast Neoplasms In conclusion, miR-181a-5p facilitated tumor progression through NDRG2-induced activation of PTEN/AKT signaling pathway of breast cancer, suggesting that focusing on miR-181a-5p may provide new insight for breast cancer therapy.Abbreviations Brdu: Bromodeoxyuridine; CCK-8: Cell Counting Kit-8; miRNA: microRNAs; mut: mutant; RT-qPCR: real-time quantitative polymerase chain reaction; UTR: untranslated region; WT: wild-type. +lncRNA target 34951337 hsa-mir-410 Cardiomegaly 3p mediated Ang II-induced cardiac hypertrophy via targeting inhibition of Smad7. +genetics_overexpression_suppress 34951005 hsa-mir-490 Stomach Neoplasms 3p restrained proliferation, migration, invasion and stimulated apoptosis of GC cells, which was attenuated by overexpression of AURKA. +lncRNA target 34950770 hsa-mir-376c Thyroid Cancer, Papillary In conclusion, LINC00475 promotes PTC cell proliferation, migration, and invasion by upregulating ZCCHC12 via the interaction with miR-376c-3p. +lncRNA target 34950682 hsa-mir-182 Liver Diseases, Alcoholic 5p significantly increases lipid accumulation in ALD by targeting FOXO1, thereby providing novel scientific insights and potential therapeutic targets for ALD. +other 34950658 hsa-mir-587 Glioblastoma By performing dual-luciferase reporter gene and RNA pull-down assays, we verified that circRFX3 could sponge microRNA-587 (miR-587) to exercise its function as a competing endogenous RNA (ceRNA) in the development of GBM. In conclusion, circRFX3 could act as a cancer-promoting circRNA to boost the development of GBM and regulate the miR-587/PDIA3/beta-catenin axis. +other 34950596 hsa-mir-98 Endometrial Neoplasms The purpose of this research is to determine whether MRP-7 has a role in mediating the sensitivity of EC cells to paclitaxel and whether the expression of MRP-7 is regulated by miR-98 and lncRNA NEAT1. Taken together, these findings demonstrate that upregulation of MRP-7 and NEAT1, and downregulation of miR-98 have important roles in conferring paclitaxel resistance to EC cells. +circulation_biomarker_diagnosis_ns 34950438 hsa-mir-21 Pancreatitis To explore the role of circulating blood miR-155 and miR-21 in promoting acute pancreatitis (AP) and evaluating the risk stratification of pancreatitis. +circulation_biomarker_diagnosis_ns 34950438 hsa-mir-155 Pancreatitis To explore the role of circulating blood miR-155 and miR-21 in promoting acute pancreatitis (AP) and evaluating the risk stratification of pancreatitis. +genetics_overexpression_promote 34950224 hsa-mir-138 Osteosarcoma RESULTS: Compared with that of the control group, the expression of miR-138 in PBMC and CD4+CXCR5+ Tfh cells of the OS group was lower; overexpression of miR-138 could promote the maturation of Tfh cells and immature B cells. +genetics_overexpression_promote 34950209 hsa-mir-33a Breast Neoplasms Moreover, overexpression of GRM8 abrogated the inhibitive role of miR-33a-5p played in breast cancer. +target gene 34950208 hsa-mir-1252 Stomach Neoplasms circABCB10 can promote the proliferation, invasion, and clonal formation of gastric cancer cells by targeting miR-1252-5p and upregulating the expression of MYC. +lncRNA target 34950131 hsa-mir-10 White Spot Syndrome Virus Infection Functional analysis validated that miR-10c could target LvToll3 to inhibit its expression, through which miR-10c blocked the nuclear translocation of IRF and facilitated white spot syndrome virus (WSSV) infection. +lncRNA target 34950131 hsa-mir-10c White Spot Syndrome Virus Infection Functional analysis validated that miR-10c could target LvToll3 to inhibit its expression, through which miR-10c blocked the nuclear translocation of IRF and facilitated white spot syndrome virus (WSSV) infection. +lncRNA target 34949180 hsa-let-7a Ovarian Neoplasms In this study, a novel nano targeted co-delivery system modified by hyaluronic acid (HA) was developed by using gold nanorods coated with functionalized mesoporous silica nanoparticles (HA-PTX/let-7a-GNR@MSN) for combined delivery of hydrophobic chemotherapy drug Paclitaxel (PTX) and lethal-7a (let-7a), a microRNA (miR), to overcome MDR in ovarian cancer. +lncRNA target 34949159 hsa-mir-1245b Osteosarcoma In conclusion, the HCG11/miR-1245b-5p/PKP2 axis promotes OS expression by promoting cell proliferation, migration, and invasion, and inhibiting apoptosis. +lncRNA target 34948431 hsa-mir-216a Colonic Neoplasms This study supports the miR-216a/GDF15 axis as a diagnostic/prognostic panel for COAD, identifies Th1, Treg, eosinophils, and NKTs as counteracting factors, indicates potential relationships underlying immunomodulation, mitochondrial organization, apoptotic signaling, and ER stress and unveil Gemcitabine as a potential drug for the development of treatment strategy when combined with targeting GDF15. +other 34948417 hsa-mir-1290 Pancreatic Carcinoma We found that expression of five miRNAs, including miR-10b, miR-16, miR-155, miR-429, and miR-1290, was markedly higher in PDEs. +other 34948417 hsa-mir-10b Pancreatic Carcinoma We found that expression of five miRNAs, including miR-10b, miR-16, miR-155, miR-429, and miR-1290, was markedly higher in PDEs. +other 34948417 hsa-mir-429 Pancreatic Carcinoma We found that expression of five miRNAs, including miR-10b, miR-16, miR-155, miR-429, and miR-1290, was markedly higher in PDEs. +other 34948417 hsa-mir-155 Pancreatic Carcinoma We found that expression of five miRNAs, including miR-10b, miR-16, miR-155, miR-429, and miR-1290, was markedly higher in PDEs. +other 34948417 hsa-mir-16 Pancreatic Carcinoma We found that expression of five miRNAs, including miR-10b, miR-16, miR-155, miR-429, and miR-1290, was markedly higher in PDEs. +other 34948403 hsa-mir-361 Diabetic Retinopathy Case studies performed on diabetic retinopathy and hsa-mir-361 also validated the accuracy of our model. +genetics_GWAS 34948154 hsa-mir-16 Carcinoma, Non-Small-Cell Lung erlotinib regimen is more effective than the selumetinib-erlotinib combination in KRAS-mutated NSCLC. +circulation_biomarker_diagnosis_up 34947913 hsa-mir-146a Arthritis, Rheumatoid Serum was used to detect the relative expression levels of lnc-PVT1 and miR-146a and we correlated the levels with RA and OA activity and severity signs. +other 34946964 hsa-mir-222 Cardiomyopathy, Hypertrophic 5p, were considered. +other 34946964 hsa-mir-497 Cardiomyopathy, Hypertrophic 5p, were considered. +other 34946964 hsa-mir-21 Cardiomyopathy, Hypertrophic 5p, were considered. +other 34946964 hsa-mir-1 Cardiomyopathy, Hypertrophic 5p, were considered. +other 34946964 hsa-mir-93 Cardiomyopathy, Hypertrophic 5p, were considered. +other 34946964 hsa-mir-155 Cardiomyopathy, Hypertrophic 5p, were considered. +other 34946964 hsa-mir-29a Cardiomyopathy, Hypertrophic 5p, were considered. +other 34946964 hsa-mir-19b Cardiomyopathy, Hypertrophic 5p, were considered. +other 34946964 hsa-mir-451a Cardiomyopathy, Hypertrophic 5p, were considered. +other 34946964 hsa-mir-133a Cardiomyopathy, Hypertrophic 5p, were considered. +other 34946964 hsa-mir-221 Cardiomyopathy, Hypertrophic 5p, were considered. +other 34946964 hsa-mir-199a Cardiomyopathy, Hypertrophic 5p, were considered. +lncRNA target 34946880 hsa-mir-138 Melanoma 5p Suppresses Cell Growth and Migration in Melanoma by Targeting Recent evidence suggests the existence of a miRNA regulatory network involving human telomerase reverse transcriptase gene (hTERT), with miR +lncRNA target 34946859 hsa-mir-199a Squamous Cell Carcinoma of Head and Neck Our in silico analysis and luciferase reporter assay identified paxillin (PXN) as a direct target of both miR +lncRNA target 34946859 hsa-mir-199b Squamous Cell Carcinoma of Head and Neck Our previous study revealed that the miR-199 family (miR-199a-5p/-3p and miR-199b-5p/-3p) acts as tumor-suppressive miRNAs in head and neck squamous cell carcinoma (HNSCC). +circulation_biomarker_diagnosis_ns 34946826 hsa-mir-20a Sepsis The present study proposes to legitimize in sepsis a characteristic found in platelets that suffer storage lesions in blood banks, which is the increased expression of miRNA miR-320a in relation to miR-127. +circulation_biomarker_diagnosis_ns 34946826 hsa-mir-127 Sepsis The present study proposes to legitimize in sepsis a characteristic found in platelets that suffer storage lesions in blood banks, which is the increased expression of miRNA miR-320a in relation to miR-127. +epigenetics 34946098 hsa-mir-145 Epstein-Barr Virus Infections Therefore, EBV alone or jointly with HPV is associated with down-regulation of miR-145 and may influence on miR-145 promoter methylation through the induction of DNMT3B in OSCC. +epigenetics 34946098 hsa-mir-145 Squamous Cell Carcinoma of Head and Neck Therefore, EBV alone or jointly with HPV is associated with down-regulation of miR-145 and may influence on miR-145 promoter methylation through the induction of DNMT3B in OSCC. +exosome 34945712 hsa-mir-335 Multiple Myeloma miR-335-laden B Cell-Derived Extracellular Vesicles Promote SOX4-Dependent Apoptosis in Human Multiple Myeloma Cells. +circulation_biomarker_diagnosis_ns 34945431 hsa-mir-17 Colorectal Neoplasms 3p in the blood plasma of a patient diagnosed with colorectal cancer has been demonstrated. +circulation_biomarker_diagnosis_up 34945242 hsa-let-7c Infertility The levels of miR-let-7a, miR-let-7b, and miR-let-7c were significantly up-regulated, and the level of miR-518f was significantly down-regulated in the seminal plasma of the azoospermic men compared to the healthy control. +circulation_biomarker_diagnosis_up 34945242 hsa-let-7b Infertility The levels of miR-let-7a, miR-let-7b, and miR-let-7c were significantly up-regulated, and the level of miR-518f was significantly down-regulated in the seminal plasma of the azoospermic men compared to the healthy control. +circulation_biomarker_diagnosis_up 34945242 hsa-let-7a Infertility The levels of miR-let-7a, miR-let-7b, and miR-let-7c were significantly up-regulated, and the level of miR-518f was significantly down-regulated in the seminal plasma of the azoospermic men compared to the healthy control. +circulation_biomarker_diagnosis_up 34945242 hsa-mir-518f Infertility The levels of miR-let-7a, miR-let-7b, and miR-let-7c were significantly up-regulated, and the level of miR-518f was significantly down-regulated in the seminal plasma of the azoospermic men compared to the healthy control. +other 34944897 hsa-mir-3687 Prostatic Neoplasms, Castration-Resistant The RNA biomarkers: KLK3 mRNA, miR-375, miR-3687, and NAALADL2-AS2 were measured in 93 patients with mCRPC, before and 1 month after start of first-line abiraterone acetate or enzalutamide treatment, in two prospective clinical trials. +other 34944897 hsa-mir-375 Prostatic Neoplasms, Castration-Resistant The RNA biomarkers: KLK3 mRNA, miR-375, miR-3687, and NAALADL2-AS2 were measured in 93 patients with mCRPC, before and 1 month after start of first-line abiraterone acetate or enzalutamide treatment, in two prospective clinical trials. +target gene 34944877 hsa-mir-335 Ovarian Neoplasms miR-335 Restrains the Aggressive Phenotypes of Ovarian Cancer Cells by Inhibiting COL11A1. +exosome 34944871 hsa-mir-150 Lung Neoplasms We revealed CD226 downregulation and functional repression of NK cells after hypoxic lung cancer priming and we then investigated their interaction with extracellular vesicles (EVs) and miR5p. +target gene 34944818 hsa-mir-210 Pancreatic Neoplasms Antagonistic Roles of the Tumor Suppressor miR-210-3p and Oncomucin MUC4 Forming a Negative Feedback Loop in Pancreatic Adenocarcinoma. +genetics_knock down_promote 34944742 hsa-mir-6315 Bone Diseases Currently, microRNAs (miRNAs) are emerging as vital mediators involved in bone/bone marrow fat homeostasis and our previous studies have demonstrated that miR-6315 was upregulated in bones of MTX-treated rats, which might be associated with bone/fat imbalance by directly targeting Smad2. Our findings indicated that miR-6315 may be important in regulating osteogenesis and adipogenesis and might be a therapeutic target for preventing/attenuating MTX treatment-associated bone loss and marrow adiposity. +other 34944712 hsa-mir-154 Squamous Cell Carcinoma of Head and Neck The implementation of miR-154 as a biomarker may improve the effectiveness of HNSCC treatment. +lncRNA target 34944699 hsa-mir-150 Carcinoma, Non-Small-Cell Lung The aim of the study here was to further investigate the tumor-suppressive roles of miR +transcription factor target 34944582 hsa-mir-22 Liver Cirrhosis The antifibrotic activities of SGNPs mediated through enhancing the hepatic expression of the protective miRNAs; miR-22, miR-29c, and miR-219a which results in suppressed expression of the main fibrosis mediators; TGFbetaR1, COL3A1, and TGFbetaR2, respectively. +transcription factor target 34944582 hsa-mir-219a Liver Cirrhosis The antifibrotic activities of SGNPs mediated through enhancing the hepatic expression of the protective miRNAs; miR-22, miR-29c, and miR-219a which results in suppressed expression of the main fibrosis mediators; TGFbetaR1, COL3A1, and TGFbetaR2, respectively. +transcription factor target 34944582 hsa-mir-29c Liver Cirrhosis The antifibrotic activities of SGNPs mediated through enhancing the hepatic expression of the protective miRNAs; miR-22, miR-29c, and miR-219a which results in suppressed expression of the main fibrosis mediators; TGFbetaR1, COL3A1, and TGFbetaR2, respectively. +circulation_biomarker_diagnosis_ns 34944567 hsa-mir-181a Liver Cirrhosis The aim of this study was to evaluate the correlation between the serum levels of the microRNAs miR-21, miR-29a, miR-122, miR-155 and miR-181a and the phenotypic expression of NAFLD. miR-181a can be used as a non-invasive method of predicting fibrosis in NAFLD, and an association with FIB-4 has the potential to increase the accuracy of each method alone. +circulation_biomarker_diagnosis_ns 34944567 hsa-mir-181a Non-alcoholic Fatty Liver Disease The aim of this study was to evaluate the correlation between the serum levels of the microRNAs miR-21, miR-29a, miR-122, miR-155 and miR-181a and the phenotypic expression of NAFLD. miR-181a can be used as a non-invasive method of predicting fibrosis in NAFLD, and an association with FIB-4 has the potential to increase the accuracy of each method alone. +other 34944497 hsa-mir-34a Carcinoma, Non-Small-Cell Lung The present study aimed to clarify the role of miR-34a in the EMT-related phenotypes of human non-small cell lung cancer (NSCLC) cell lines, A549 (p53 wild-type) and H1299 (p53-deficient). CONCLUSION: These findings indicate a close relationship between p53 and miR-34a-induced EMT in p53-wild type NSCLC cells, which provides novel insights about the role of miR-34a in EMT-like phenotypic changes in NSCLC. +circulation_biomarker_diagnosis_ns 34944484 hsa-let-7c Hypertension METHODS: We cross-sectionally evaluated the clinical and carotid characteristics as well as serum expression of miR +circulation_biomarker_diagnosis_ns 34944484 hsa-let-7c Plaque, Atherosclerotic METHODS: We cross-sectionally evaluated the clinical and carotid characteristics as well as serum expression of miR +circulation_biomarker_diagnosis_ns 34944484 hsa-mir-145 Plaque, Atherosclerotic METHODS: We cross-sectionally evaluated the clinical and carotid characteristics as well as serum expression of miR +circulation_biomarker_diagnosis_ns 34944484 hsa-mir-145 Hypertension METHODS: We cross-sectionally evaluated the clinical and carotid characteristics as well as serum expression of miR +other 34944116 hsa-mir-202 Anovulation On the other hand, the mir3p expression profile reflected levels of oocyte maturation molecular markers (star, lhr) and both histological and molecular (casp3) levels of follicular atresia. +other 34944037 hsa-mir-497 Atrophy 5p is likely involved in a compensatory mechanism of muscle atrophy in response to IL-6. +other 34944012 hsa-mir-139 COVID-19 Using expression data from an independent study, we validated and identified two high-confidence miRNAs, namely, hsa-miR-30a-3p and hsa-miR5p, which have putative causal effects on developing cases of severe COVID-19. +other 34943987 hsa-mir-16 Alzheimer Disease A meta-analysis, whenever possible, revealed miR3p and miR-16 as consistently downregulated in late-stage AD across the literature. +other 34943987 hsa-mir-132 Alzheimer Disease A meta-analysis, whenever possible, revealed miR3p and miR-16 as consistently downregulated in late-stage AD across the literature. +other 34943807 hsa-mir-24 Endometritis 3p could give a therapeutic option for endometritis and other disorders commonly associated with endometritis, suggesting a novel avenue for endometritis treatment. +genetics_overexpression_suppress 34942624 hsa-mir-181a Asthma CONCLUSION: miR-181a-5p overexpression reduced the binding of HMGB1 and RAGE by inhibiting HMGB1, thus alleviating Treg/Th17 immune imbalance and blocking AR from developing into asthma. +genetics_overexpression_suppress 34942624 hsa-mir-181a Rhinitis, Allergic CONCLUSION: miR-181a-5p overexpression reduced the binding of HMGB1 and RAGE by inhibiting HMGB1, thus alleviating Treg/Th17 immune imbalance and blocking AR from developing into asthma. +lncRNA target 34942272 hsa-mir-21 Fluorosis, Dental 5p might be a potential therapeutic target for skeletal fluorosis. +genetics_overexpression_promote 34942190 hsa-mir-204 Venous Thrombosis 5p overexpression lentivirus plasmid were injected into the DVT rat model. +other 34941030 hsa-mir-208 Myocardial Infarction, Acute Mir-208 had a highly effective diagnostic capacity to distinguish AMI from chest pain patients with an AUC of 93%. MiR-208 was sufficient to distinguish AMI patients with chest pain from healthy controls. +lncRNA target 34939978 hsa-mir-532 Squamous Cell Carcinoma of Head and Neck 3p could inhibit cell proliferation viability, adhesion, and migration in TSCC. +genetics_knock down_promote 34939762 hsa-mir-582 Carcinoma, Non-Small-Cell Lung 3p overexpression or knockdown of RGMB remarkably reversed the malignant phenotypes of NSCLC cells induced by the up-regulation of circ_0001073 expression. +other 34939761 hsa-mir-34a Carcinoma, Non-Small-Cell Lung Restoration of MiR-34a Expression by 5-Azacytidine Augments Alimta -Induced Cell Death in Non-Small Lung Cancer Cells by Downregulation of HMG B1, A2 and Bcl-2 Pathway. +other 34939557 hsa-mir-200a Dengue p. +other 34939557 hsa-mir-590 Dengue p. +other 34939557 hsa-mir-101 Dengue p. +other 34939557 hsa-mir-34a Dengue p. +other 34939557 hsa-mir-363 Dengue p. +other 34939557 hsa-mir-9 Dengue p. +other 34939557 hsa-mir-374a Dengue p. +transcription factor target 34939145 hsa-mir-122 Reperfusion Injury Furthermore, the inhibition of miRNA-122 suppressed the IR injury-induced activation of the TLR signaling pathway. Of these, miRNA-122 promoted IR injury following LT, whereas its inhibition prevented IR injury in a TLR-dependent manner. +lncRNA target 34938603 hsa-mir-129 Glioma 5P), which partially alleviated the inhibitory effect of miR +circRNA target 34938599 hsa-mir-760 Abortion, Habitual Furthermore, mechanistic dissection revealed that circRNA-DURSA exerts its effects by competitively binding to miR-760, which post-transcriptionally targets HIST1H2BE. These results reveal the regulatory roles of circRNA-DURSA in trophoblasts and identified a distinct circRNA-DURSA/miR-760/HIST1H2BE axis as potentially important diagnostic and therapeutic targets for URSA treatment. +lncRNA target 34938598 hsa-mir-4470 Colorectal Neoplasms Data from mechanism assays revealed that circPTEN could elevate PTEN expression through sequestering microRNA-4470 (miR-4470) in CRC cells. +genetics_overexpression_promote 34938358 hsa-mir-144 Thyroid Neoplasms 5p inhibited ITGA3 expression in TC, and its overexpression remarkably reversed the tumor-promoting effects of overexpressed ITGA3 on the biological functions of TC. +genetics_GWAS 34938351 hsa-mir-107 Schizophrenia rs1625579 within miR-137, rs6577555 within miR-34, and rs2296616 within miR-107 were sequenced in 150 cases and 150 controls to check the potential association between the SNPs and SCZ. +genetics_GWAS 34938351 hsa-mir-137 Schizophrenia rs1625579 within miR-137, rs6577555 within miR-34, and rs2296616 within miR-107 were sequenced in 150 cases and 150 controls to check the potential association between the SNPs and SCZ. +other 34938350 hsa-mir-298 Atrial Fibrillation In conclusion, our data find that circFAT1(e2) sponges miR-298 and then regulates MYB expression, thus affecting atrial fibrillation progression. +other 34938320 hsa-mir-429 Kidney Calculi Conclusion: We found that significant expressions of ceRNAs (NEAT1, PVT1, hsa-miR-23b-3p, hsa-miR-429, hsa-miR5p, CCL7, and ROBO2) and infiltrating immune cells (macrophages and mast cells) may be involved in kidney stone pathogenesis. +other 34938320 hsa-mir-139 Kidney Calculi Conclusion: We found that significant expressions of ceRNAs (NEAT1, PVT1, hsa-miR-23b-3p, hsa-miR-429, hsa-miR5p, CCL7, and ROBO2) and infiltrating immune cells (macrophages and mast cells) may be involved in kidney stone pathogenesis. +other 34938320 hsa-mir-23b Kidney Calculi Conclusion: We found that significant expressions of ceRNAs (NEAT1, PVT1, hsa-miR-23b-3p, hsa-miR-429, hsa-miR5p, CCL7, and ROBO2) and infiltrating immune cells (macrophages and mast cells) may be involved in kidney stone pathogenesis. +other 34938314 hsa-mir-103 Endomyocardial Fibrosis CircRNA455-miR-127, circRNA455-miR-29a, circRNA455-miR-103, circRNA4557-mir149-5p, and circRNA2440-mir-23a might be involved in the IMF deposition process. +other 34938314 hsa-mir-29a Endomyocardial Fibrosis CircRNA455-miR-127, circRNA455-miR-29a, circRNA455-miR-103, circRNA4557-mir149-5p, and circRNA2440-mir-23a might be involved in the IMF deposition process. +other 34938314 hsa-mir-23a Endomyocardial Fibrosis CircRNA455-miR-127, circRNA455-miR-29a, circRNA455-miR-103, circRNA4557-mir149-5p, and circRNA2440-mir-23a might be involved in the IMF deposition process. +other 34938314 hsa-mir-127 Endomyocardial Fibrosis CircRNA455-miR-127, circRNA455-miR-29a, circRNA455-miR-103, circRNA4557-mir149-5p, and circRNA2440-mir-23a might be involved in the IMF deposition process. +other 34938314 hsa-mir-149 Endomyocardial Fibrosis CircRNA455-miR-127, circRNA455-miR-29a, circRNA455-miR-103, circRNA4557-mir149-5p, and circRNA2440-mir-23a might be involved in the IMF deposition process. +transcription factor target 34938197 hsa-mir-184 Dementia, Vascular 5p in OGD-injured cells, in line with the improved cell viability. +transcription factor target 34938197 hsa-mir-6875 Dementia, Vascular 5p in OGD-injured cells, in line with the improved cell viability. +other 34938191 hsa-mir-184 Diabetic Nephropathies, Proliferative 3p were highly expressed in PDR patients, and intravitreal aflibercept injection could reverse this alteration. +other 34938191 hsa-mir-197 Diabetic Nephropathies, Proliferative 3p were highly expressed in PDR patients, and intravitreal aflibercept injection could reverse this alteration. +other 34938191 hsa-mir-24 Diabetic Nephropathies, Proliferative 3p were highly expressed in PDR patients, and intravitreal aflibercept injection could reverse this alteration. +exosome 34938180 hsa-mir-29 Pulmonary Fibrosis loaded exosomes for PF treatment. +target gene 34938121 hsa-mir-421 Stomach Neoplasms LncRNA FENDRR Inhibits Gastric Cancer Cell Proliferation and Invasion via the miR-421/SIRT3/Notch-1 Axis. +lncRNA target 34938119 hsa-mir-940 Nasopharyngeal Carcinoma 3/KPNA2 axis is pro-oncogenic in NPC progression, uncovering novel insights into targeted therapy for this disorder. +other 34938111 hsa-mir-449c Cleft Palate qRT-PCR results revealed significantly lower expression levels of lncRNA USP17L6P and c-Myc in NSCL/P tissues, while the expression level of hsa-miR-449c-5p was higher as compared to control samples (p < 0.05). +other 34938111 hsa-mir-449c Cleft Palate, Non-Syndromic qRT-PCR results revealed significantly lower expression levels of lncRNA USP17L6P and c-Myc in NSCL/P tissues, while the expression level of hsa-miR-449c-5p was higher as compared to control samples (p < 0.05). +lncRNA target 34937878 hsa-mir-138 Colorectal Neoplasms In particular, we show that miR-138 inhibits MYC expression and suppresses tumor growth of CRC and hepatocellular carcinoma (HCC) cell lines. +lncRNA target 34937878 hsa-mir-138 Carcinoma, Hepatocellular In particular, we show that miR-138 inhibits MYC expression and suppresses tumor growth of CRC and hepatocellular carcinoma (HCC) cell lines. +other 34937832 hsa-mir-195 Diabetic Retinopathy In OG, the mRNA and protein expression levels of miR-195 and BAX were high, whereas those of BCL-2 and SIRT1 were low. +lncRNA target 34937502 hsa-mir-18a Osteoporosis Upregulation of miR-18a-3p restrained the activity and expression of ALP in hBMSCs, inhibited the expression of RUNX2, OCN, and OPN, and inhibited calcium deposition. +lncRNA target 34937497 hsa-mir-338 Glioma In conclusion, SNHG18 accelerates glioma progression via regulating the miR +circulation_biomarker_diagnosis_up 34936736 hsa-mir-27b Colorectal Neoplasms CONCLUSION: Exosomal miR-27b-3p secreted by EMT-CRC cells increases blood vessel permeability and facilitates the generation of CTCs. +lncRNA target 34936303 hsa-mir-556 Carcinoma, Hepatocellular Propofol inhibited HCC cell proliferation and EMT progress via NORAD/miR3p/MIEN1 axis. +lncRNA target 34936297 hsa-mir-548k Stomach Neoplasms We confirmed that the HDAC3/lncRNA-LET/miR-548k signal axis mediated the occurrence and development of GC, and HDAC3 could be a novel therapeutic target for the treatments of GC. +other 34936294 hsa-mir-10b Infarction, Middle Cerebral Artery The oxygen-glucose deprivation (OGD) induced SH-SY5Y cell model and middle cerebral artery occlusion model (MCAO) rats were constructed to investigate the role of miR-10b-3p and underline the regulatory mechanism of miR-10b-3p/PDCD5 axis in cerebral I/R injury. +other 34936294 hsa-mir-10b Reperfusion Injury Previous studies have demonstrated that miR-10b-3p is significantly downregulated in rats after cerebral ischemia injury, and this study aimed to investigate the effect of miR-10b-3p in cerebral ischemia/reperfusion (I/R) injury. +genetics_overexpression_promote 34936294 hsa-mir-10b Ischemic Stroke MiR-10b-3p overexpression could efficiently inhibit cell viability and proliferation, induce apoptosis of OGD/R-induced SH-SY5Y cells in vitro, and attenuate cerebral I/R injury of MCAO rats in vivo. +genetics_overexpression_suppress 34936294 hsa-mir-10b Brain Injuries Silencing of PDCD5 showed similar effect to miR-10b-3p mimics, while PDCD5 overexpression significantly reversed the protective effects of miR-10b-3p mimics on cerebral I/R injury. +genetics_overexpression_suppress 34936294 hsa-mir-10b Brain Ischemia Silencing of PDCD5 showed similar effect to miR-10b-3p mimics, while PDCD5 overexpression significantly reversed the protective effects of miR-10b-3p mimics on cerebral I/R injury. +genetics_overexpression_promote 34936288 hsa-mir-494 Carcinoma, Non-Small-Cell Lung In NSCLC cells, overexpression of PCAT29 led to down-regulated miR-494 and up-regulated PTEN. +transcription factor target 34936240 hsa-mir-21 Glioblastoma In this work, a novel targeted antisense miRNA-21 oligonucleotide (ATMO-21) delivery system is developed for GBM treatment. +transcription factor target 34936021 hsa-mir-128 Acquired Immunodeficiency Syndrome Integrating SEV proteome and miRNAome revealed a significant decrease in the enrichment of disease-associated, brain-enriched, and HIV-associated miR3p (miR-128) in HIV COC SEV with a concomitant increase in miR-128 targets-PEAK1 and RND3/RhoE. +lncRNA target 34935899 hsa-mir-495 Triple Negative Breast Neoplasms 3p mimics could down-regulate GRP78 expression via the p-AKT/mTOR signaling pathway in TNBC cells. +other 34935307 hsa-mir-4729 Diabetic Retinopathy CONCLUSIONS: The present study showed that ATP2B1-AS1 acted as a miR-4729 sponge to regulate IQGAP2 reducing high-glucose-induced endothelial dysfunction in DR. +transcription factor target 34935255 hsa-mir-3 Fatty Liver Interestingly, the relative abundance of miR-33 in goose fatty liver was significantly higher than that in normal liver, while the relative mRNA and protein abundances of CROT, the target gene of miR-33, in goose fatty liver were significantly lower than those in goose normal liver. Taken together, these findings suggest that miR-33 mediates glucose promotion of lipid accumulation in goose primary liver cells, and that glucose participates in formation of goose fatty liver by regulating the expression of miR-33/CROT. +other 34935248 hsa-mir-1299 Hemoglobin Bart'S Hydrops Fetalis Syndrome Downregulations of hsa-miR-1299 and hsa-miR5p in ceRNA network were also validated by RT-qPCR. +other 34935248 hsa-mir-625 Hemoglobin Bart'S Hydrops Fetalis Syndrome Downregulations of hsa-miR-1299 and hsa-miR5p in ceRNA network were also validated by RT-qPCR. +other 34935052 hsa-mir-182 Benign Paroxysmal Positional Vertigo miR1825pbased therapy can influence the expression of ANG and BDNF, which demonstrates the potential for treating RNV diseases. +other 34935052 hsa-mir-182 Retroviridae Infections miR1825pbased therapy can influence the expression of ANG and BDNF, which demonstrates the potential for treating RNV diseases. +other 34934837 hsa-mir-100 Colorectal Neoplasms For miRNA cargo, we previously showed that when compared to isogenic colorectal cancer (CRC) cells expressing wild-type KRAS, a distinct subset of miRNAs are differentially enriched in EVs from KRAS mutant active CRC cells, with miR-100 being one of the most enriched. +circulation_biomarker_diagnosis_up 34934442 hsa-mir-208a Coronary Disease Bioinformatics analysis and dual-luciferase reporter assays indicated that B-cell translocation gene 1 (BTG1) was a direct target gene of miR-208a-3p, and was downregulated in the peripheral blood samples of patients with CHD. +other 34934434 hsa-mir-499a Kidney Failure, Chronic The present study aimed to investigate the association of the miRNA-499a gene (MIR499A) A/G seed region variant (rs3746444) with DN-associated ESRD susceptibility in patients with diabetes mellitus, and to determine whether there was an association between the different genotypes and the patients' laboratory and clinical data. +other 34934434 hsa-mir-499a Diabetes Mellitus, Type 2 The present study aimed to investigate the association of the miRNA-499a gene (MIR499A) A/G seed region variant (rs3746444) with DN-associated ESRD susceptibility in patients with diabetes mellitus, and to determine whether there was an association between the different genotypes and the patients' laboratory and clinical data. +lncRNA target 34934431 hsa-mir-609 Triple Negative Breast Neoplasms Taken together, the results of the present study suggest that miR-3609 plays a vital role in mediating cell cycle arrest and inhibiting the proliferation of TNBC cells. +other 34934349 hsa-mir-124 Hypoplastic Left Heart Syndrome 3p, etc.) were detected and indicated the possible involvement of NF-kappaB signaling pathways in mitochondrial dysfunction in HLHS. +other 34934349 hsa-mir-191 Hypoplastic Left Heart Syndrome 3p, etc.) were detected and indicated the possible involvement of NF-kappaB signaling pathways in mitochondrial dysfunction in HLHS. +other 34934349 hsa-mir-155 Hypoplastic Left Heart Syndrome 3p, etc.) were detected and indicated the possible involvement of NF-kappaB signaling pathways in mitochondrial dysfunction in HLHS. +other 34934046 hsa-mir-1238 Carcinoma, Renal Cell Our study thus provided evidence that the regulatory network involving circPPP6R3/miR3p/CD44 axis might provide promising biomarkers as well as a therapeutic approach for ccRCC. +lncRNA target 34933738 hsa-mir-103 Breast Neoplasms This study aimed to evaluate the expression level of lncRNA-GAS5 and its target APOBEC3C in women with breast cancer through expression evaluation of miR-103. In conclusion, we observed down-regulation of APOBEC3C and LncRNA-GAS5 and up-regulation of miRNA 103 in breast cancer patients. +lncRNA target 34933738 hsa-mir-103a Breast Neoplasms This study aimed to evaluate the expression level of lncRNA-GAS5 and its target APOBEC3C in women with breast cancer through expression evaluation of miR-103. In conclusion, we observed down-regulation of APOBEC3C and LncRNA-GAS5 and up-regulation of miRNA 103 in breast cancer patients. +circulation_biomarker_diagnosis_up 34933711 hsa-mir-141 Hepatitis B Receiver operating characteristic (ROC) curve analyses suggested that serum has mir141-5p and mir501-5p none significant diagnostic value for HBV infection. +circulation_biomarker_diagnosis_up 34933711 hsa-mir-501 Hepatitis B Receiver operating characteristic (ROC) curve analyses suggested that serum has mir141-5p and mir501-5p none significant diagnostic value for HBV infection. +other 34933640 hsa-mir-20a Osteoporosis To investigate the role of MYC and miR320a in osteoporosis, MYC or miR-320a expression were knocked down in RAW 264.7 cells. +exosome 34933177 hsa-mir-24 Cardiomyopathies 3p from M2 macrophages-derived exosomes (M2-exo) could protect against myocardial injury after sepsis. +exosome 34933177 hsa-mir-24 Sepsis 3p from M2 macrophages-derived exosomes (M2-exo) could protect against myocardial injury after sepsis. +other 34932851 hsa-mir-24 Burns 3p is conducive to rehabilitating the denatured dermis, which may be beneficial in providing effective therapy of skin burns. +genetics_overexpression_suppress 34931960 hsa-mir-4709 Pulmonary Fibrosis 3p overexpression could advance obstructive renal fibrosis via LATS2 targeting in Hippo signaling pathway. +genetics_overexpression_promote 34931871 hsa-mir-539 Myocardial Infarction, Acute Overexpression of miR +circulation_biomarker_diagnosis_up 34931755 hsa-mir-379 Parkinson Disease The serum of patients with ischemic stroke and OGD-treated HCN-2 cells displayed a poor expression of miR +circulation_biomarker_diagnosis_up 34931755 hsa-mir-379 Brain Ischemia The serum of patients with ischemic stroke and OGD-treated HCN-2 cells displayed a poor expression of miR +other 34931559 hsa-mir-335 Colorectal Neoplasms Also, miR5p from the HgA signature was higher in AWD patients before surgery (Kruskal-Wallis test: p-value = 0.019). +other 34931559 hsa-mir-378a Colorectal Neoplasms RESULTS: Although the signatures did not predict recurrence, expression of the miRNAs from the CL signature decreased 1 year after surgery, and one miRNA of the signature, miR-378a-3p, almost reached significance in the NED subgroup (Wilcoxon signed-rank test: p-value = 0.078). +transcription factor target 34931339 hsa-mir-126 Skin Diseases Our results revealed that decreased miR-126 in psoriatic CD4(+) T cells might accelerate the formation of skin lesions through promoting the differentiation of Th17 cells, thus suggesting a potential intervention target for psoriasis. +other 34931228 hsa-mir-21 Prostatic Neoplasms This systematic review and meta-analysis suggests that elevated levels of miR-21 are associated with poor prognosis in PCa patients. +circRNA target 34930906 hsa-mir-541 Carcinoma, Hepatocellular 5p inhibitor suppressed tumor growth and reversed the effect of circMTO1 silencing on the promotion of tumor growth in HCC. +genetics_knock down_suppress 34930894 hsa-mir-93 Carcinoma, Pancreatic Ductal 5p, and its depletion resulted in reduced cell proliferation, invasion and migration, as observed in MYEOV-knockdown PDAC cells. +genetics_knock down_suppress 34930894 hsa-mir-17 Carcinoma, Pancreatic Ductal 5p, and its depletion resulted in reduced cell proliferation, invasion and migration, as observed in MYEOV-knockdown PDAC cells. +lncRNA target 34930676 hsa-mir-424 psoriasis 1 AGAP2-AS1 promotes keratinocyte proliferation through miR5p/AKT/mTOR axis and may be a promising target for psoriasis therapy. +genetics_knock down_promote 34930675 hsa-mir-486 Carcinoma, Squamous Cell, Cutaneous Knockdown of FLOT2 promoted tumorigenesis of cSCC; whereas FLOT2 reversed the tumor-promoting effect of miR +genetics_knock down_promote 34930344 hsa-mir-338 Multiple Myeloma 3p inhibition reversed the antitumor effects of circ_0058058 knockdown on MM cell. +circRNA target 34930332 hsa-mir-516b Osteosarcoma CONCLUSION: Rg3 inhibited OS progression through circ_0003074/miR-516b-5p/KPNA4 axis, showing the potential of Rg3 as a therapeutic agent for OS. +transcription factor target 34930304 hsa-mir-6766 Liver Cirrhosis These results also proposed a significant strategy that 3D-Exo could be used as natural nanoparticles to rescue liver injury via delivering antifibrotic miR3p. +genetics_overexpression_promote 34930287 hsa-mir-200a Liver Injury Rg3 could activate autophagy to improve mitochondrial dysfunction in LPS-treated hepatocytes, which was partially reversed by TUG1 depletion or miR-200a-3p overexpression. +genetics_overexpression_promote 34930169 hsa-mir-513c Pre-Eclampsia CONCLUSIONS: Our study reveals that overexpression of placenta miR-513c-5p is involved in PE by regulating the biological functions of trophoblasts through the inhibition of LRP6. +circRNA target 34929706 hsa-mir-205 Spinal Cord Injuries CONCLUSION: Circ-Ctnnb1 promotes SCI through regulating Wnt/beta-catenin signaling via modulating the miR5p/Ctnnb1/Wnt2b axis. +other 34929656 hsa-mir-32 Brain Injuries, Traumatic Symptom severity was significantly higher on the day of injury among mTBI subjects (p < 0.001), and miRNA 32-5p levels were also higher (p = 0.009). +other 34929287 hsa-mir-410 Colorectal Neoplasms By confirming the regulatory relationship between miR3p and circMET, we propose a new mechanism for the observed sustained activation of MET in CRC. +genetics_overexpression_promote 34929233 hsa-mir-155 Cyprinid Herpesvirus 3 Overexpression of miR-155 effectively inhibited CyHV-3 replication in CCB cells and promoted type I interferon (IFN-I) expression. +genetics_knock down_promote 34929177 hsa-mir-146b Fibrosis In this process, the inhibition of PDGFRalpha in adipose tissue cells by miR-146b-5p may lead to the loss of their PDGFRalpha-induced profibrotic activities, thereby suppressing fibrosis. +lncRNA target 34927777 hsa-mir-17 Colorectal Neoplasms Functionally, SOX4 triggered drug resistance of CRC cells to 5-FU through the miR-17/CYLD axis. +other 34927541 hsa-mir-195 Thyroid Cancer, Papillary CircPVT1 could serve as a molecule sponge for miR-195 and mediate the ceRNA network to promote the expression of VEGFA, thus contributed to the malignant progression of PTC. +lncRNA target 34927513 hsa-mir-21 Inflammation CONCLUSIONS: Quercetin could protect HNEpC cells against LPS-induced inflammatory injury via inducing miR-21/DMBT1/NF-kappaB axis. +exosome 34927445 hsa-mir-320c Osteoarthritis Conclusion: SMSC-derived exosomal miR-320c enhances chondrogenesis through targeting ADAM19, highlighting a potentially novel mechanism of SMSC in treating osteoarthritis. +circulation_biomarker_diagnosis_ns 34927407 hsa-mir-101 Retinitis METHODS: Equal numbers of patients with T1DM (90) and healthy-matched control children (90) were assessed for the expression profile of plasma miRNAs including miRNA +circulation_biomarker_diagnosis_ns 34927407 hsa-mir-101 Diabetes Mellitus, Type 1 METHODS: Equal numbers of patients with T1DM (90) and healthy-matched control children (90) were assessed for the expression profile of plasma miRNAs including miRNA +circulation_biomarker_diagnosis_ns 34927407 hsa-mir-146 Diabetes Mellitus, Type 1 METHODS: Equal numbers of patients with T1DM (90) and healthy-matched control children (90) were assessed for the expression profile of plasma miRNAs including miRNA +circulation_biomarker_diagnosis_ns 34927407 hsa-mir-146 Retinitis METHODS: Equal numbers of patients with T1DM (90) and healthy-matched control children (90) were assessed for the expression profile of plasma miRNAs including miRNA +genetics_overexpression_promote 34927228 hsa-mir-648 Carcinoma, Non-Small-Cell Lung CONCLUSION: The findings from the present study indicate that the overexpression of miR-3648 serves as a useful biomarker for the prediction of prognosis in NSCLC, and promotes tumor cell proliferation, migration and invasion. +other 34926963 hsa-mir-92a Colorectal Neoplasms Here, a ratiometric fluorescent biosensor based on the Forster resonance energy transfer between fluorophores is proposed for detecting colorectal cancer-specific miRNA (miR-92a-3p). +other 34926705 hsa-mir-3666 Urinary Bladder Neoplasms Subsequently, we conducted bioinformatics analysis followed by RNA pull-down, ChIP, and luciferase reporter assays, from which we found that circRHOT1 expression in BC cells could be regulated by ZNF652, and circRHOT1 could promote SMAD5 expression to regulate BC cell cellular progression by sponging miR-3666. +other 34926693 hsa-mir-130a Chronic Periodontitis CONCLUSION: lncRNA FGD5-AS1 is lowly expressed in patients with chronic periodontitis, while miR-130a is highly expressed. +other 34926687 hsa-mir-605 Stomach Neoplasms We identified three lncRNAs (AC007785.3, AC079385.3, LINC01729), two miRNAs (miR-3174, miR-605), and clinical factors related to the pathogenesis and prognosis of GC. +other 34926670 hsa-mir-155 Hypertension, Renal 5p, which negatively regulates the expression of H2AC6. +lncRNA target 34926668 hsa-mir-1243 Hyperglycemia RESULTS: The levels of circ_0008590 and RELB were increased in hRECs in hyperglycemia; during the progression of DR, the levels of circ_0008590 and RELB messenger RNA (mRNA) in aqueous humor were first decreased and then increased, whereas miR-1243 showed an opposite trend. CONCLUSIONS: In hyperglycemia, high expression of RELB/circ_0008590 could be suppressed by miR-1243, and the nuclear factor-kappaB (NF-kappaB) pathway is subsequently affected. +other 34926662 hsa-mir-155 Hepatitis C, Chronic miR-155 regulates pro- and anti-inflammatory cytokine expression in human monocytes during chronic hepatitis C virus infection. +genetics_overexpression_promote 34926661 hsa-mir-155 Brain Injuries Subsequently, this study was designed to investigate the potential role and mechanisms of BMAL1 in SBI following ICH using lentiviral overexpression and antagomir-155 treatments. +genetics_overexpression_promote 34926661 hsa-mir-155 Cerebral Hemorrhage Subsequently, this study was designed to investigate the potential role and mechanisms of BMAL1 in SBI following ICH using lentiviral overexpression and antagomir-155 treatments. +other 34926294 hsa-mir-205 Cholangiocarcinoma Quantitative real-time PCR (qRT-PCR) showed that expressions of CHRM3.AS2, MIR205HG, and LINC00661 were higher in CCA tissues than those in normal tissues, similar to the trends detected in the CCA dataset. +lncRNA target 34926237 hsa-mir-1246 Breast Neoplasms Therefore, miR-1246 may promote drug resistance and metastasis in breast cancer by targeting NFE2L3. +genetics_knock down_suppress 34925694 hsa-mir-195 Adenocarcinoma of Lung RESULTS: Both gain- and loss-of-function assays demonstrated that miR +genetics_knock down_promote 34925640 hsa-mir-637 Thyroid Cancer, Papillary Moreover, circLDLR acted as a sponge for miR-637, and miR-637 interference reversed the anticancer effects of circLDLR knockdown on PTC cells. +lncRNA target 34925543 hsa-mir-181c Intervertebral Disc Degeneration RESULTS: hsa_circ_0001658 was significantly upregulated (logFC > 2.0 and adj.P.Val < 0.01) in the NP tissues of IDD patients, and hsa-miR-181c-5p expression was downregulated (logFC < -2.0 and adj.P.Val < 0.01). CONCLUSION: Circular RNA hsa_circ_0001658 inhibits IDD development by regulating hsa-miR-181c-5p/FAS. +target gene 34925523 hsa-mir-129 Prostatic Neoplasms Breviscapine Participates in the Progression of Prostate Cancer by Inhibiting ZFP91 Expression through Upregulation of MicroRNA-129-5p. +other 34925506 hsa-mir-20a Urinary Bladder Neoplasms MiR-20a-5p Negatively Regulates NR4A3 to Promote Metastasis in Bladder Cancer. +genetics_overexpression_promote 34925225 hsa-mir-4739 Osteoporosis In osteoporotic BMSCs, miR-4739 overexpression significantly inhibited cell viability, osteoblast differentiation, mineralized nodule formation, and heterotopic bone formation, whereas miR-4739 inhibition exerted opposite effects. +lncRNA target 34925023 hsa-mir-375 Cardiomegaly In summary, our study demonstrates that OT ameliorates cardiac hypertrophy by inhibiting PI3K/AKT pathway via lncRNA GAS5/miR +other 34924755 hsa-mir-342 Stroke CONCLUSION: In summary, lncRNA FTX enhanced the angiogenesis in stroke by acting as a sponge of miR3p to regulate the expression of SPI1 level. +genetics_overexpression_promote 34924500 hsa-mir-26b Breast Neoplasms Overexpression of miR-26b-5p also suppressed the tumorigenesis of chemoresistant BC cells in vivo. +genetics_knock down_promote 34924499 hsa-mir-489 Breast Neoplasms CircCDK1 knockdown enhanced the sensitivity of Tamoxifen in breast cancer cells and suppressed cell growth and survival by depleting CDK1 expression via releasing miR- 489-3p. +transcription factor target 34924391 hsa-mir-195 Mitochondrial Diseases BACKGROUND: Mitochondrial dysfunction is an early feature of Alzheimer's disease (AD) and miR-195 is involved in mitochondrial disorder through targeting MFN-2 protein in hippocampal neurons of AD. +circulation_biomarker_diagnosis_up 34923944 hsa-mir-126 Intracranial Aneurysm CONCLUSION: Our results indicated that circulating miR-126 in plasma samples could be served as a potential non-invasive biomarker in IAs detection and prevention IAs with a high risk of rupture. +other 34923910 hsa-mir-370 Atherosclerosis Taken together, our results show that TMAO-NEAT1/miR3p/STAT3/FMO3 forms a positive feedback loop to exacerbate the development of AS. +circulation_biomarker_diagnosis_up 34923889 hsa-mir-218 Pre-Eclampsia RESULTS: Compared with the PE group, 24-h urinary protein content, blood pressure, VEC apoptosis rate, apoptosis marker levels, and HMGB1 expression decreased while miR +lncRNA target 34923813 hsa-mir-200 Stomach Neoplasms Taken together, the HOTAIR-miR-200 axis seems to play a vital role in human GC, suggesting a potential therapeutic target in future GC treatment. +genetics_overexpression_promote 34923485 hsa-mir-1246 Ovarian Neoplasms Functionally, overexpression of miR-1246 markedly enhanced DDP resistance and cell proliferation, and suppressed cell cycle arrest and apoptosis of OC cells. +lncRNA target 34922601 hsa-mir-128 Breast Neoplasms CONCLUSION: PVT1 may act as an oncogene in breast cancer through binding miR3p and UPF1 and represents a potential target for BC therapeutic development. +circulation_biomarker_diagnosis_up 34922585 hsa-mir-181b Precursor Cell Lymphoblastic Leukemia-Lymphoma CONCLUSION: miRNA-181b-5p carried by EVs in peripheral blood of ALL patients can enter ALL cells and thus promote the malignancy of ALL cells. +lncRNA target 34922544 hsa-mir-761 Colorectal Neoplasms Mechanistically, circIL4R was regulated by TFAP2C and competitively interacted with miR-761 to enhance the expression of TRIM29, thereby targeting PHLPP1 for ubiquitin-mediated degradation to activate the PI3K/AKT signaling pathway and consequently facilitate CRC progression. +other 34922539 hsa-mir-125a Carcinoma, Renal Cell CONCLUSIONS: We found that sponging of miR-125a-5p to promote EIF4EBP1 expression is the underlying mechanism of hsa_circ_0020303-induced ccRCC progression. +transcription factor target 34922523 hsa-mir-1245b Premenstrual Syndrome qRT-PCR examination confirmed that the expression levels of miR-1245b-3p and miR-4291 were higher in PMSII than in H samples and that the expression levels of miR-1825 were higher in PMSII than in P samples. miR-4291, miR-1245b-3p and miR-1825 may be used as diagnostic markers and potential therapeutic targets for PMSII. +transcription factor target 34922523 hsa-mir-4291 Premenstrual Syndrome qRT-PCR examination confirmed that the expression levels of miR-1245b-3p and miR-4291 were higher in PMSII than in H samples and that the expression levels of miR-1825 were higher in PMSII than in P samples. miR-4291, miR-1245b-3p and miR-1825 may be used as diagnostic markers and potential therapeutic targets for PMSII. +other 34922523 hsa-mir-544a Premenstrual Syndrome However, contrary to the NGS results, qRT-PCR analysis showed decreased expression of miR544a in PMSII. +transcription factor target 34922523 hsa-mir-1825 Premenstrual Syndrome qRT-PCR examination confirmed that the expression levels of miR-1245b-3p and miR-4291 were higher in PMSII than in H samples and that the expression levels of miR-1825 were higher in PMSII than in P samples. miR-4291, miR-1245b-3p and miR-1825 may be used as diagnostic markers and potential therapeutic targets for PMSII. +genetics_overexpression_promote 34922339 hsa-mir-345 Breast Neoplasms Overexpression and inhibition of miR +genetics_knock down_promote 34922206 hsa-mir-513b Squamous Cell Carcinoma of Head and Neck CONCLUSION: Knockdown of circ_LPAR3 could inhibit the OSCC progression by sponging miR-513b-5p and activating VEGFC and AKT1. +transcription factor target 34921979 hsa-mir-155 Carcinoma, Renal Cell Here we show that miR-155 directly targets FTO to negatively regulate its expression and increased m(6)A level in ccRCC. +other 34921595 hsa-mir-184 Carcinoma, Non-Small-Cell Lung 5p and EIF5A. +transcription factor target 34921586 hsa-mir-125b Cardiotoxicity This work aims to investigate the effects of miR-125b in Dox-induced cardiotoxicity. In conclusion, our study demonstrated that miR-125b could enhance Dox-induced cardiotoxicity through targeting the STARD13/YAP axis. +other 34921580 hsa-mir-15a Neurodegenerative Diseases Our study suggests that miR-15a-5p, miR-15b-5p, miR5p, miR-301a-3p, and lncRNA NEAT1 may represent effective epigenomic markers associated with neurodegenerative diseases caused by toluene. +other 34921580 hsa-mir-15b Neurodegenerative Diseases Our study suggests that miR-15a-5p, miR-15b-5p, miR5p, miR-301a-3p, and lncRNA NEAT1 may represent effective epigenomic markers associated with neurodegenerative diseases caused by toluene. +other 34921580 hsa-mir-16 Neurodegenerative Diseases Our study suggests that miR-15a-5p, miR-15b-5p, miR5p, miR-301a-3p, and lncRNA NEAT1 may represent effective epigenomic markers associated with neurodegenerative diseases caused by toluene. +lncRNA target 34921567 hsa-mir-125a Parkinson Disease BACKGROUND: This study aimed to investigate the correlation of long non-coding RNA antisense non-coding RNA in the INK4 locus (lncRNA ANRIL) and its target microRNAs (microRNA-34a (miR-34a) and microRNA-125a (miR-125a)) with disease risk and severity of Parkinson's disease (PD). +lncRNA target 34921567 hsa-mir-34a Parkinson Disease BACKGROUND: This study aimed to investigate the correlation of long non-coding RNA antisense non-coding RNA in the INK4 locus (lncRNA ANRIL) and its target microRNAs (microRNA-34a (miR-34a) and microRNA-125a (miR-125a)) with disease risk and severity of Parkinson's disease (PD). +other 34921525 hsa-mir-1 Breast Neoplasms 3p, OR: 1.39, 95% CI: 1.01-1.91). +other 34921525 hsa-mir-382 Breast Neoplasms 3p, OR: 1.39, 95% CI: 1.01-1.91). +other 34921177 hsa-mir-17 Carcinoma, Non-Small-Cell Lung PPAR and miR-17 may be markers differentiating tumour tissue from surgical margin and miR-17 may have diagnostic role in NSCLC histotypes differentiation. +lncRNA target 34921037 hsa-mir-183 Stomach Neoplasms CONCLUSION: miR-183 can influence the proliferation, apoptosis and autophagy of GC cells through targeted inhibition of mTOR expression. +circulation_biomarker_prognosis_ns 34920681 hsa-mir-451 Atherosclerosis RESULTS: The expression of miR-451a was significantly decreased in the serum of AS patients. +circulation_biomarker_prognosis_ns 34920681 hsa-mir-451a Atherosclerosis RESULTS: The expression of miR-451a was significantly decreased in the serum of AS patients. +genetics_GWAS 34920653 hsa-mir-125b common variable immunodeficiency 2 Our results suggest that overexpression of miR-125b-5p affects the terminal differentiation of B cells in a selected group of CVID patients by downregulating the BLIMP-1 gene and more intensively for the IRF-4 gene expressions. +other 34920184 hsa-mir-374c Breast Neoplasms Together, these findings demonstrated that m6A modification of pri-miRNA-374c blocks miRNA-374c-5p maturation and then activates GRM3 expression, which drives BC cell metastasis after Cd exposure. +genetics_knock down_promote 34920123 hsa-mir-20a Urinary Bladder Neoplasms However, the function of miR-320a was opposite to that of TUG1, and miR-320a inhibitor partially eliminated the inhibitory effect of TUG1 knockdown on the malignant behavior of BC cells. +other 34919704 hsa-mir-1908 Diabetes Mellitus, Type 2 Finally, by integrating the miRNA-eQTLs and Japanese genome-wide association studies of 25 complex traits (mean n = 192833), we conducted a transcriptome-wide association study, identifying miR5p as a potential mediator for adult height, colorectal cancer and type 2 diabetes (P < 9.1 10-5). +other 34919695 hsa-mir-146a Muscular Atrophy, Spinal However, miR-146a, known to be upregulated in SMA-induced pluripotent stem cell (iPSC)-derived astrocytes, showed increased expression in nusinersen-treated CSF samples. We then used mRNA sequencing and multi-electrode arrays to assess the transcriptional and functional effects of miR-146a on healthy and SMA iPSC-derived motor neurons. +transcription factor target 34919671 hsa-mir-1983 Metabolic Diseases Our findings provide evidence for miR-1983 as a unique biomarker of cellular insulin resistance, and a potential therapeutic target for prevention of human metabolic disease. +circulation_biomarker_diagnosis_ns 34919671 hsa-mir-1983 Insulin Resistance Importantly, we demonstrate that miR-1983 is detectable in human blood serum and that its levels significantly correlate with blood insulin and the homeostatic model assessment of insulin resistance. Our findings provide evidence for miR-1983 as a unique biomarker of cellular insulin resistance, and a potential therapeutic target for prevention of human metabolic disease. +genetics_overexpression_promote 34919276 hsa-mir-214 Multiple Myeloma 3p and miR-5100 overexpression increase MM cell proliferation and resistance to bortezomib-induced apoptosis by switching the balance between pro-/anti-apoptotic proteins. +genetics_overexpression_promote 34919276 hsa-mir-5100 Multiple Myeloma 3p and miR-5100 overexpression increase MM cell proliferation and resistance to bortezomib-induced apoptosis by switching the balance between pro-/anti-apoptotic proteins. +genetics_knock down_suppress 34919120 hsa-mir-183c Keratitis CONCLUSIONS: Prophylactic miR-183C knockdown is protective against PA keratitis through its regulation of innate immunity, corneal innervation, and neuroimmune interactions. +lncRNA target 34919034 hsa-mir-1205 Thyroid Cancer, Papillary Circ_0000644 could directly interact with miR-1205 to repress the expression of miR-1205, and it served as a miR-1205 sponge to modulate E2F3 expression in PTC cells. Circ_0000644 up-regulates E2F3 expression via sponging miR-1205 to promote PTC progression. +circRNA target 34919024 hsa-mir-146b Carcinoma, Non-Small-Cell Lung Circ_0014235 downregulation reduced Gefitinib IC50, inhibited cell proliferation and induced cell apoptosis and cell cycle arrest in Gefitinib-resistant NSCLC cells, while these effects were reversed by the inhibition of miR-146b-5p, a target of circ_0014235. Circ_0014235 confers Gefitinib resistance and malignant behaviors in Gefitinib-resistant NSCLC by governing the miR-146b-5p/YAP/PD-L1 pathway. +lncRNA target 34919012 hsa-mir-606 Esophageal Squamous Cell Carcinoma Our results indicate the oncogene role of circGOT1 in ESCC via an endogenous competition RNA (ceRNA) mechanism to promote GOT1 expression via sponging miR-606. +other 34918978 hsa-mir-143 Ventricular Dysfunction, Right In this study, we aimed to estimate the association between miR-143/145 rs4705343 and the risk of CHD in a Chinese Tibetan population. Conclusion: The present study suggests that the rs4705343 CC genotype of miR-143/145 is associated with CHD risk in a Chinese Tibetan population. +other 34918978 hsa-mir-145 Ventricular Dysfunction, Right In this study, we aimed to estimate the association between miR-143/145 rs4705343 and the risk of CHD in a Chinese Tibetan population. Conclusion: The present study suggests that the rs4705343 CC genotype of miR-143/145 is associated with CHD risk in a Chinese Tibetan population. +genetics_knock down_promote 34918962 hsa-mir-210 Hepatoblastoma Knockdown of MIR210HG reduced proliferation, migration, and invasion in liver cancer cells, and suppressed tumor growth in vivo. +genetics_knock down_suppress 34918962 hsa-mir-608 Hepatoblastoma CONCLUSION: Our study demonstrated that knockdown of MIR210HG inhibits hepatoblastoma development through binding to miR-608 and downregulating FOXO6. Our results provide novel insights for hepatoblastoma treatment involving the MIR210HG-miR608-FOXO6 axis. +lncRNA target 34918563 hsa-mir-133b Carcinoma, Endometrioid Conclusion: The findings from the present study suggested that miR-133b may be a tumor suppressor gene and a potential therapeutic target for the treatment of EC. +other 34917801 hsa-mir-106a Alzheimer Disease RESULTS: Among the 16 experimentally verified miRNAs, Network analysis of the LGMN and its associated miRNA identify novel hsa-miRNA-106a-5p and hsa-miRNA-34a-5p being more expressed in the brain. +other 34917801 hsa-mir-34a Alzheimer Disease RESULTS: Among the 16 experimentally verified miRNAs, Network analysis of the LGMN and its associated miRNA identify novel hsa-miRNA-106a-5p and hsa-miRNA-34a-5p being more expressed in the brain. +circulation_biomarker_diagnosis_up 34917685 hsa-mir-146a Diabetes Mellitus, Type 2 The AUC cutoff values of circulating miRNAs, miR-146a and miR-144; myokines, adropin and irisin; and serum OPN were significantly identified by ROC analysis which additionally recommends the potential use of these biomarkers, miR-146a, miR-144, adropin, irisin, and OPN, as diagnostic biomarkers with considerable specificity and sensitivity for diabetes in patients with varying glycemic control status. +circulation_biomarker_diagnosis_up 34917685 hsa-mir-144 Diabetes Mellitus, Type 2 The AUC cutoff values of circulating miRNAs, miR-146a and miR-144; myokines, adropin and irisin; and serum OPN were significantly identified by ROC analysis which additionally recommends the potential use of these biomarkers, miR-146a, miR-144, adropin, irisin, and OPN, as diagnostic biomarkers with considerable specificity and sensitivity for diabetes in patients with varying glycemic control status. +circulation_biomarker_diagnosis_ns 34917657 hsa-mir-126a Myocardial Reperfusion Injury Mechanistically, RIPC-exosome, especially exosomal miR-126a-3p, activated the reperfusion injury salvage kinase (RISK) pathway by enhancing the phosphorylation of Akt and Erk1/2, and simultaneously inhibited Caspase-3 mediated apoptotic signaling. Conclusions: Our findings reveal a novel myocardial protective mechanism that plasma exosomes at the late phase of RIPC attenuate myocardial ischemia-reperfusion injury via exosomal miR-126a-3p. +other 34917535 hsa-mir-155 Nasopharyngeal Carcinoma CONCLUSION: Taken together, miR-155 in NPC was upregulated. +lncRNA target 34917510 hsa-mir-326 Carcinoma, Hepatocellular LMNB2 axis may be a potential therapeutic target for HCC. +circulation_biomarker_diagnosis_ns 34917199 hsa-mir-146 Hypertension, Pulmonary 30 patients with PAH and 20 healthy volunteers in our hospital were enrolled, and their serum samples were extracted for the detection of microRNA +other 34917156 hsa-mir-499 Cardiovascular Diseases CONCLUSIONS: We proved that ferulic acid protects cardiomyocytes from oxidative stress-induced injury by regulating the miR5p/p21signaling pathway, which provides insight into the clinical application of ferulic acid in the treatment of cardiovascular diseases. +other 34917094 hsa-mir-155 Acquired Immunodeficiency Syndrome We found that in PLWH-derived MDMs, pro-inflammatory signals (TNFA, IL6, IL1B, miR5p, and IDO1) dominate over negative feedback signals (NCOR2, GSN, MSC, BIN1, and miR-146a-5p), favoring an abnormally trained phenotype. +other 34917094 hsa-mir-146a Acquired Immunodeficiency Syndrome We found that in PLWH-derived MDMs, pro-inflammatory signals (TNFA, IL6, IL1B, miR5p, and IDO1) dominate over negative feedback signals (NCOR2, GSN, MSC, BIN1, and miR-146a-5p), favoring an abnormally trained phenotype. +transcription factor target 34916847 hsa-mir-1306 lung squamous cell carcinoma CONCLUSION: miR-1306 functions as a prognostic indicator and tumor promoter of LUSC through targeting RBM3, which provides a potential therapeutic target of LUSC. +target gene 34916840 hsa-mir-659 Carcinoma, Non-Small-Cell Lung β-Caryophyllene from Chilli Pepper Inhibits the Proliferation of Non-Small Cell Lung Cancer Cells by Affecting miR-659-3p-Targeted Sphingosine Kinase 1 (SphK1). +other 34916825 hsa-mir-6848 Burns 3p, hsa-miR-550a-3p, and hsa-miR-550b-3p). +other 34916825 hsa-mir-4739 Burns 3p, hsa-miR-550a-3p, and hsa-miR-550b-3p). +other 34916825 hsa-mir-6751 Burns 3p, hsa-miR-550a-3p, and hsa-miR-550b-3p). +other 34916825 hsa-mir-365a Burns 3p, hsa-miR-550a-3p, and hsa-miR-550b-3p). +other 34916825 hsa-mir-4754 Burns 3p, hsa-miR-550a-3p, and hsa-miR-550b-3p). +other 34916825 hsa-mir-1224 Burns 3p, hsa-miR-550a-3p, and hsa-miR-550b-3p). +other 34916825 hsa-mir-550b Burns 3p, hsa-miR-550a-3p, and hsa-miR-550b-3p). +other 34916825 hsa-mir-6878 Burns 3p, hsa-miR-550a-3p, and hsa-miR-550b-3p). +other 34916825 hsa-mir-4684 Burns 3p, hsa-miR-550a-3p, and hsa-miR-550b-3p). +other 34916825 hsa-mir-6754 Burns 3p, hsa-miR-550a-3p, and hsa-miR-550b-3p). +other 34916825 hsa-mir-718 Burns 3p, hsa-miR-550a-3p, and hsa-miR-550b-3p). +other 34916825 hsa-mir-4786 Burns 3p, hsa-miR-550a-3p, and hsa-miR-550b-3p). +other 34916825 hsa-mir-6739 Burns 3p, hsa-miR-550a-3p, and hsa-miR-550b-3p). +other 34916825 hsa-mir-6795 Burns 3p, hsa-miR-550a-3p, and hsa-miR-550b-3p). +other 34916825 hsa-mir-6884 Burns 3p, hsa-miR-550a-3p, and hsa-miR-550b-3p). +other 34916825 hsa-mir-550a Burns 3p, hsa-miR-550a-3p, and hsa-miR-550b-3p). +other 34916611 hsa-mir-204 Chanarin-Dorfman Syndrome The results show that GAS5 was up-regulated, whereas miR3p was down-regulated in anterior lens capsule tissues of DC patients and in HG-treated LECs compared to their controls, respectively. +genetics_overexpression_promote 34915882 hsa-mir-103a Melanoma The suppressive impact of TEX41 depletion on melanoma cell malignant behaviors could be counteracted by miR-103a-3p inhibition or C1QB overexpression. CONCLUSIONS: IRF4-activated TEX41 sequestered miR-103a-3p and modulated C1QB to promote melanoma cell malignant behaviors, for which TEX41 might be regarded as a potential therapeutic target for melanoma. +lncRNA target 34914969 hsa-mir-489 Reperfusion Injury, Cerebral Ischemia 3p obviously attenuated cerebral I/R injury by increasing PC12 cell viability, reducing LDH release, and inhibiting cell apoptosis. +transcription factor target 34914964 hsa-mir-195 Bicuspid Aortic Valve Disease 5p expression by binding its promoter region and partially promotes calcification through a SMAD-dependent pathway. +circulation_biomarker_diagnosis_ns 34914874 hsa-mir-26a Triple Negative Breast Neoplasms The MQD@Au NBs heterostructure-based ECL sensing system was applied to determine miRNA-26a in the serum of patients with triple-negative breast cancer. +circulation_biomarker_prognosis_up 34914790 hsa-mir-147b Shock, Septic CONCLUSIONS: The plasma miR-147b may be an useful biomarker independently or in combination with PCT to support clinical diagnosis of sepsis and equally prognosis of patients with septic shock. +lncRNA target 34914716 hsa-mir-20a Colorectal Neoplasms In summary, our study investigates the targetome of the TSS-miRNAs in colorectal cancer cells and establishes miR-320a as a regulator of unfolded protein response. +lncRNA target 34914251 hsa-mir-588 Hamartoma Syndrome, Multiple 5p up-regulated, and the target genes of the differentially expressed miRNAs positively regulated the apoptosis of the testicular cells. +other 34914251 hsa-mir-138 Arrest of spermatogenesis 5p, miR-181d-5p, miR-19a-3p and miR-3588 regulate CS-induced apoptosis of testicular cells, and may become biomarkers for early diagnosis and prognosis of CS-induced spermatogenesis obstruction.left angle bracket, double. +lncRNA target 34914251 hsa-mir-138 Hamartoma Syndrome, Multiple 5p up-regulated, and the target genes of the differentially expressed miRNAs positively regulated the apoptosis of the testicular cells. +other 34914251 hsa-mir-588 Arrest of spermatogenesis 5p, miR-181d-5p, miR-19a-3p and miR-3588 regulate CS-induced apoptosis of testicular cells, and may become biomarkers for early diagnosis and prognosis of CS-induced spermatogenesis obstruction.left angle bracket, double. +lncRNA target 34914251 hsa-mir-155 Hamartoma Syndrome, Multiple 5p up-regulated, and the target genes of the differentially expressed miRNAs positively regulated the apoptosis of the testicular cells. +other 34914251 hsa-mir-155 Arrest of spermatogenesis 5p, miR-181d-5p, miR-19a-3p and miR-3588 regulate CS-induced apoptosis of testicular cells, and may become biomarkers for early diagnosis and prognosis of CS-induced spermatogenesis obstruction.left angle bracket, double. +other 34914251 hsa-mir-181d Arrest of spermatogenesis 5p, miR-181d-5p, miR-19a-3p and miR-3588 regulate CS-induced apoptosis of testicular cells, and may become biomarkers for early diagnosis and prognosis of CS-induced spermatogenesis obstruction.left angle bracket, double. +lncRNA target 34914251 hsa-mir-181d Hamartoma Syndrome, Multiple 5p up-regulated, and the target genes of the differentially expressed miRNAs positively regulated the apoptosis of the testicular cells. +lncRNA target 34914251 hsa-mir-19a Hamartoma Syndrome, Multiple 5p up-regulated, and the target genes of the differentially expressed miRNAs positively regulated the apoptosis of the testicular cells. +other 34914251 hsa-mir-19a Arrest of spermatogenesis 5p, miR-181d-5p, miR-19a-3p and miR-3588 regulate CS-induced apoptosis of testicular cells, and may become biomarkers for early diagnosis and prognosis of CS-induced spermatogenesis obstruction.left angle bracket, double. +circRNA target 34914211 hsa-mir-339 Prostatic Neoplasms CONCLUSIONS: Hsa_circ_0005221 enhances the progression of prostate cancer through the miR +lncRNA target 34913989 hsa-mir-193b Diabetes Mellitus, Type 2 CONCLUSIONS/INTERPRETATION: Our results identified a previously unrecognised role of miR-193b in muscle function and mass that could be a potential therapeutic target for treating sarcopenia. +other 34913774 hsa-mir-21 Carcinoma, Non-Small-Cell Lung Additionally, we detected miR-21 with the maximum Sen of 0.74 [95%CI: 0.62-0.83], miR-146 with the maximum Spe and AUC of 0.93 [95%CI: 0.79-0.98] and 0.89 [95%CI: 0.86-0.92] for early-stage NSCLC. We also identified the diagnostic power of available panel (miR-210, miR-31 and miR-21) for NSCLC with satisfying Sen, Spe and AUC of 0.82 [95%CI: 0.78-0.84], 0.87 [95%CI: 0.84-0.89] and 0.91 [95%CI: 0.88-0.93], and furtherly constructed 2 models for better diagnosis. +other 34913774 hsa-mir-21 Lung Neoplasms Additionally, we detected miR-21 with the maximum Sen of 0.74 [95%CI: 0.62-0.83], miR-146 with the maximum Spe and AUC of 0.93 [95%CI: 0.79-0.98] and 0.89 [95%CI: 0.86-0.92] for early-stage NSCLC. We also identified the diagnostic power of available panel (miR-210, miR-31 and miR-21) for NSCLC with satisfying Sen, Spe and AUC of 0.82 [95%CI: 0.78-0.84], 0.87 [95%CI: 0.84-0.89] and 0.91 [95%CI: 0.88-0.93], and furtherly constructed 2 models for better diagnosis. +other 34913724 hsa-mir-188 Diabetic Nephropathies Possibly germacrone-based treatment for DN can be further motivated by regulating mmu_circRNA_0000309/miR3p/GPX4 signaling axis. +circRNA target 34913472 hsa-mir-766 Carcinoma, Squamous Cell, Cutaneous 3p/HOXA9 axis, which might provide a promising therapeutic target for CSCC. +circulation_biomarker_diagnosis_ns 34913274 hsa-mir-29a Inflammation, Chronic In summary, our work suggests that EV-associated miR-29a-3p plays a crucial role in MUD and might be used as a potential blood-based biomarker for detecting chronic inflammation and synaptic damage. +circulation_biomarker_diagnosis_ns 34913223 hsa-mir-516b Leukemia, Myeloid, Acute Peripheral blood samples were obtained from healthy volunteers and AML patients for the measurement of circ_0040823 and miR-516b levels. +lncRNA target 34913063 hsa-mir-145 Triple Negative Breast Neoplasms CircRNA_0044556 diminished the sensitivity of TNBC cells to ADM via the miR145/NRAS axis. +genetics_knock down_suppress 34912856 hsa-mir-188 Angelman Syndrome Conclusion: Circ_0003204 knockdown mitigated ox-LDL-induced injury in HCtAECs and THP-1 cells via regulating the miR3p/TRPC6 axis, indicating that circ_0003204 might play an important role in carotid artery AS. +genetics_knock down_suppress 34912856 hsa-mir-188 Carotid Artery Diseases Conclusion: Circ_0003204 knockdown mitigated ox-LDL-induced injury in HCtAECs and THP-1 cells via regulating the miR3p/TRPC6 axis, indicating that circ_0003204 might play an important role in carotid artery AS. +circRNA target 34912844 hsa-mir-1281 Glioblastoma Analyses of the predicted target miRNAs of circLRRC7 in CSCD and CRI databases, in combination with the miRNA expression data in GBMs and normal brains from GSE database, revealed miR-1281 as a potential downstream target of circLRRC7. In summary, circLRRC7 may be a tumor suppressor that associated with miR-1281 and PDXP expression in GBM, which may provide novel therapeutic targets for GBM treatment. +lncRNA target 34912799 hsa-mir-520h Endometrial Neoplasms Conclusion: Hsa_circ_0001860 plays an important role in the development of MPA resistance in EC through miR-520h/Smad7 axis, and it could be targeted to reverse the MPA resistance in endometrial cancer. +lncRNA target 34912799 hsa-mir-520 Endometrial Neoplasms Conclusion: Hsa_circ_0001860 plays an important role in the development of MPA resistance in EC through miR-520h/Smad7 axis, and it could be targeted to reverse the MPA resistance in endometrial cancer. +lncRNA target 34912458 hsa-mir-429 Squamous Cell Carcinoma of Head and Neck Moreover, LINC01303 promoted OSCC through miR-429/ZEB1 axis both in vivo and in vitro. +lncRNA target 34912331 hsa-mir-337 Tuberculosis Thus, TB-driven single MIR337-3p species could specifically target/impair both TLR4/MYD88 and STAT3 activation signals, inhibiting VitD-dependent antimicrobial response and fast-acting anti-TB immunity, leading to enhanced pathogenicity. +circulation_biomarker_diagnosis_ns 34912238 hsa-mir-1 Myocardial Infarction The multivariate logistic regression analysis showed that high levels of miR-146a, AST, LDH, and IL-6 in serum were risk factors, while low IMA contents were a protective factor for cardiovascular adaptation during exercise. +circulation_biomarker_diagnosis_ns 34912238 hsa-mir-146a Myocardial Infarction The multivariate logistic regression analysis showed that high levels of miR-146a, AST, LDH, and IL-6 in serum were risk factors, while low IMA contents were a protective factor for cardiovascular adaptation during exercise. +other 34912235 hsa-mir-18a Cardiomyopathies NG-HTN demonstrated increased sympatho-excitation with concomitant reduction in UPR(mt), miRNA-18a-5p and increased level of HIF-1alpha in the heart. +other 34912235 hsa-mir-18a Hypertension NG-HTN demonstrated increased sympatho-excitation with concomitant reduction in UPR(mt), miRNA-18a-5p and increased level of HIF-1alpha in the heart. +other 34912073 hsa-mir-371a Adenocarcinoma of Lung If this can be confirmed in larger cohorts, monitoring miR-371a-3p could replace surveillance imaging in seminomatous GCT and reduce the amount of imaging in non-seminomatous GCT. +other 34912073 hsa-mir-371a Germ Cell Tumor, Non-Teratomatous If this can be confirmed in larger cohorts, monitoring miR-371a-3p could replace surveillance imaging in seminomatous GCT and reduce the amount of imaging in non-seminomatous GCT. +lncRNA target 34911869 hsa-mir-147a Diabetic Nephropathies Altogether, KCNQ1OT1 mediated the proliferation, ECM accumulation, inflammation, and oxidative stress in HG-treated HGMC cells via miR-147a/SOX6 axis, which might be a novel target for DN therapy. +transcription factor target 34911834 hsa-mir-21 Thyroid Neoplasms 5p in thyroid cancer cells can target the expression of SOSTDC1 and affect the activities of PI3K/Akt and MAPK/ERK, thereby inhibiting the apoptosis of thyroid cancer cells and promoting cell proliferation and migration. +lncRNA target 34911832 hsa-mir-20 Inflammation The results indicated that miR3p inhibition suppressed H(2)O(2)- induced inflammation, apoptosis, and oxidative stress and promoted the osteogenic differentiation of MC3T3- E1 cells by regulating RUNX2, ALP, and OCN, and this effect was further strengthened by E2. +other 34911544 hsa-mir-129 Pancreatic Carcinoma CONCLUSIONS: Altogether, the exploration of FOXA1/MIR99AHG/miR5p/ELAVL1/NOTCH2 axis in the progression of PCa might provide a meaningful revelation for PCa diagnosis and treatment. +genetics_GWAS 34911543 hsa-mir-196a-2 Uterine Cervical Neoplasms The miRNA-196a2 rs11614913 mutation was significantly associated with a reduced risk of cervical cancer in homozygous model (OR = 0.641, 95% CI = 0.447-0.919, P = 0.016; TT vs. CONCLUSION: In summary, this meta-analysis shows that the mutant genotypes of miRNA-146a rs2910164 and miRNA-196a2 rs11614913 are associated with a reduced risk of cervical cancer. +other 34911533 hsa-mir-141 Stomach Neoplasms based therapy. +genetics_overexpression_promote 34911016 hsa-mir-140 Squamous Cell Carcinoma of Head and Neck 5p overexpression suppressed LSCC cell proliferation and migration. +circulation_biomarker_diagnosis_ns 34910910 hsa-mir-150 Dengue Here, we identify a human-blood-derived microRNA, hsa-miR5p, that interferes with a mosquito antiviral system to facilitate flavivirus infection and transmission. +other 34910765 hsa-mir-155 Inflammation 11-fold upregulation of MiR5p specifically was found in LS vs. +other 34910765 hsa-mir-155 Lichen Sclerosus et Atrophicus 11-fold upregulation of MiR5p specifically was found in LS vs. +other 34910493 hsa-mir-34a Breast Neoplasms In this study, a chitosan-based, self-assembled nanosystem that codelivered microRNA34a (miR34a) and doxorubicin (Dox) with hyaluronic acid (HA) modification (named CCmDH NPs) was developed to reverse the resistance of breast cancer (BCa) cells to Dox. This study provides evidence for the anticancer activity of CCmDH NPs carrying Dox and miR34a in BCa, especially metastatic Dox-resistant BCa models. +other 34910443 hsa-mir-193a Diabetic Nephropathies miR-193a-3p, miR-1260B, and miR-3175 extensively participate in the development of cancer, arthritis, osteogenic differentiation, Alzheimer's disease, and other diseases, as well as in the regulation of MAPK/ERK, TLR4/NF-kappaB, and other signaling pathways. +other 34910443 hsa-mir-1260b Diabetic Nephropathies miR-193a-3p, miR-1260B, and miR-3175 extensively participate in the development of cancer, arthritis, osteogenic differentiation, Alzheimer's disease, and other diseases, as well as in the regulation of MAPK/ERK, TLR4/NF-kappaB, and other signaling pathways. +other 34910443 hsa-mir-3175 Diabetic Nephropathies miR-193a-3p, miR-1260B, and miR-3175 extensively participate in the development of cancer, arthritis, osteogenic differentiation, Alzheimer's disease, and other diseases, as well as in the regulation of MAPK/ERK, TLR4/NF-kappaB, and other signaling pathways. +lncRNA target 34910364 hsa-mir-19b Atherosclerosis Collectively, this study demonstrates that M-EVs containing miR-19b-3p accelerate migration and promotion of VSMCs through targeting JAZF1, which promotes the development of atherosclerosis. +genetics_GWAS 34908444 hsa-mir-122 Hepatitis C However, bicistronic HCV replicons and full-length RNAs with specific mutations in the 5' untranslated region (UTR) can replicate, albeit to low levels, without miR-122. +lncRNA target 34907898 hsa-mir-155 Nephritis, Interstitial Also, CD8(+) T cell exhaustion was also worsened in the absence of miR-155 via targeting of SHIP-1 and SOCS1, showing as up-regulated recruitment of Tregs and expression of PD-1, and down-regulated expression of IFN-gamma and TNF-alpha in CD8(+) T cells. +circulation_biomarker_diagnosis_down 34907223 hsa-mir-197 Encephalomyelitis, Western Equine Circulating miR +lncRNA target 34907204 hsa-mir-130a Carcinoma, Hepatocellular This indicates LINC00667 functions as a tumor promotor in promoting HCC progression through targeting miR-130a-3p/AR axis, making a novel biomarker and potential therapeutic target for HCC. +exosome 34907166 hsa-mir-1246 Colitis Our study not only showed that by restoring the Th17 cell/Treg balance through the miR-1246/Nfat5 axis, the 3D culture system improved the function of MSC-exos in the treatment of periodontitis, but also it provided a basis for treating inflammatory bowel disease (IBD) by restoring immune responses in the inflamed periodontium. +exosome 34907166 hsa-mir-1246 Periodontitis Our study not only showed that by restoring the Th17 cell/Treg balance through the miR-1246/Nfat5 axis, the 3D culture system improved the function of MSC-exos in the treatment of periodontitis, but also it provided a basis for treating inflammatory bowel disease (IBD) by restoring immune responses in the inflamed periodontium. +other 34907157 hsa-mir-122 Inflammation As the Hippo pathway plays important roles in cell proliferation and liver pathological processes like inflammation, fibrosis, and hepatocellular carcinoma (HCC), our study could also provide a new insight into the function of miR-122 in liver pathology. +other 34907157 hsa-mir-122 Fibrosis As the Hippo pathway plays important roles in cell proliferation and liver pathological processes like inflammation, fibrosis, and hepatocellular carcinoma (HCC), our study could also provide a new insight into the function of miR-122 in liver pathology. +other 34907157 hsa-mir-122 Carcinoma, Hepatocellular As the Hippo pathway plays important roles in cell proliferation and liver pathological processes like inflammation, fibrosis, and hepatocellular carcinoma (HCC), our study could also provide a new insight into the function of miR-122 in liver pathology. +circRNA target 34906917 hsa-mir-942 Colorectal Neoplasms Collectively, circ_0007919 inhibits CRC cell growth and migration via regulating the miR +lncRNA target 34906656 hsa-mir-142a Intestinal Diseases Upregulating the expression of miR-142a-3p inhibited radiation-induced pyroptosis in HIEC, and downregulating the expression of miR-142a-3p led to radiation-induced pyroptosis in HIEC after FlaA N/C pretreatment. +circulation_biomarker_diagnosis_up 34906298 hsa-mir-146a Neonatal Sepsis Conclusion The expression of miR-146a-3p is down-regulated and the expression of IL-17 is up-regulated in peripheral blood CD4(+) T cells of children with neonatal sepsis. +target gene 34906151 hsa-mir-606 Pancreatic Neoplasms CircSEC24A upregulates TGFBR2 expression to accelerate pancreatic cancer proliferation and migration via sponging to miR-606. +epigenetics 34906138 hsa-mir-146b Hematologic Neoplasms RESULTS: In SCLL, FGFR1 activation silences miR-146b-5p through DNMT1-mediated promoter methylation, which derepresses the downstream target IRAK1. +target gene 34906136 hsa-mir-9 Pancreatic Neoplasms Targeted intervention of eIF4A1 inhibits EMT and metastasis of pancreatic cancer cells via c-MYC/miR-9 signaling. +other 34906045 hsa-mir-21 Gliosis Although miR-21 has been reported as an astrocytic miRNA with an important role in astrogliosis, no link between this miRNA and cellular senescence of astrocytes has been identified. +circulation_biomarker_diagnosis_up 34906021 hsa-mir-24 Brain Neoplasms Subgroup analyses were performed for sample types (serum/plasma), reference genes (RNU6, miR-39, and miR-24), and region to determine the diagnostic power of microRNAs in the diagnosis of BT using pooled sensitivity, specificity, PLR, NLR, AUC, and DOR. +circulation_biomarker_diagnosis_up 34906021 hsa-mir-9 Brain Neoplasms Subgroup analyses were performed for sample types (serum/plasma), reference genes (RNU6, miR-39, and miR-24), and region to determine the diagnostic power of microRNAs in the diagnosis of BT using pooled sensitivity, specificity, PLR, NLR, AUC, and DOR. +lncRNA target 34905503 hsa-mir-21 Osteosarcoma CONCLUSIONS: Circ_0008259 suppresses OS progression via regulating miR +lncRNA target 34905435 hsa-mir-92b Squamous Cell Carcinoma of Head and Neck In conclusion, our results suggest that the SP1/miR-92b feedback loop generally promotes HNSCC invasion and metastasis, thus presenting a possible therapeutic target in the treatment of HNSCC patients. +other 34905060 hsa-mir-103a Glioblastoma CONCLUSIONS: We suggest that the NF-kappaB-YY1-miR-103a regulatory axis is indispensable for the function of RTP cells in driving radioresistance and recurrence. +circulation_biomarker_diagnosis_up 34904915 hsa-mir-150 Acute Kidney Injury 5p plasma levels in COVID-19 patients may support enhanced SARS-CoV-2 infection. +other 34904852 hsa-mir-155 Hashimoto Disease The new side of the study was the miRNA-21 and miRNA-155 expressions were in line with other parameters in both the HT and sitagliptin-treated HT groups. +other 34904852 hsa-mir-21 Hashimoto Disease The new side of the study was the miRNA-21 and miRNA-155 expressions were in line with other parameters in both the HT and sitagliptin-treated HT groups. +transcription factor target 34904343 hsa-mir-548p Carcinoma, Hepatocellular ATF2 promoted HCC cell proliferation, migration and invasion and inhibited cell apoptosis through directly targeting miR-548p and controlling its expression. +circRNA target 34904327 hsa-mir-564 Prostatic Neoplasms CONCLUSIONS: Blocking circDPP4 antagonizes cell progression of PC and contributes to in vitro DTX cytotoxicity via regulating the miR-564/ZIC2 axis, at least. +genetics_overexpression_promote 34904279 hsa-mir-20a Oculocutaneous Albinism Type 3 It was found that miR-20a-5p or miR-190a-5p overexpression markedly decreased PAR-1 mRNA level and protein expression in SH-SY5Y cells cultured with HG and normal glucose, indicating that miR-20a or miR-19a deficiency contributed to HG-induced PAR-1 upregulation. +genetics_overexpression_promote 34904279 hsa-mir-190a Oculocutaneous Albinism Type 3 It was found that miR-20a-5p or miR-190a-5p overexpression markedly decreased PAR-1 mRNA level and protein expression in SH-SY5Y cells cultured with HG and normal glucose, indicating that miR-20a or miR-19a deficiency contributed to HG-induced PAR-1 upregulation. +other 34904279 hsa-mir-93 Oculocutaneous Albinism Type 3 Moreover, we predicted and determined several potential microRNAs (miRs) combining with the 3'-UTR of PAR-1 mRNA, finding that miR-20a-5p, miR5p, and miR-190a-5p were significantly decreased in HG-cultured SH-SY5Y cells compared with control. +genetics_overexpression_promote 34904279 hsa-mir-19a Oculocutaneous Albinism Type 3 It was found that miR-20a-5p or miR-190a-5p overexpression markedly decreased PAR-1 mRNA level and protein expression in SH-SY5Y cells cultured with HG and normal glucose, indicating that miR-20a or miR-19a deficiency contributed to HG-induced PAR-1 upregulation. +circulation_biomarker_diagnosis_up 34904043 hsa-mir-9 Carcinoma, Hepatocellular RESULTS: The levels of circulating miRNA 9-3p were significantly lower in the HCC group compared to the chronic liver disease (P < 0.001) and control (P < 0.001) groups, while levels in the chronic liver disease were significantly lower than those in the control group (P < 0.001). +genetics_overexpression_promote 34903799 hsa-mir-1179 Carcinoma, Hepatocellular CircFOXM1 silencing inhibited malignant phenotypes in HCC cells were partly rescued by either miR-1179 silencing or SPAG5 overexpression. +genetics_overexpression_suppress 34903711 hsa-mir-411 Carcinoma, Hepatocellular KPNA2 silencing, miR5p overexpression, and AKT inhibitor (MK2206) consistently reversed KDM4A-AS1-enhanced proliferation, mobility, and EMT of HCC cells. +other 34903157 hsa-mir-9 Seizures Therefore, early cellular response to seizures in the brain includes induction of the Ntrk2, Ntrk3, Ngfr, miRNA-9, and miRNA-29a expression, as well as activation of Bcl-2 and Bax signaling pathways, which may characterize them as important mediators of neuronal adaptation and survival upon induction of the generalized brain activity. +other 34903157 hsa-mir-29a Seizures Therefore, early cellular response to seizures in the brain includes induction of the Ntrk2, Ntrk3, Ngfr, miRNA-9, and miRNA-29a expression, as well as activation of Bcl-2 and Bax signaling pathways, which may characterize them as important mediators of neuronal adaptation and survival upon induction of the generalized brain activity. +genetics_overexpression_promote 34903128 hsa-mir-200a Osteosarcoma Overexpression of miR-200a inhibits osteosarcoma cell proliferation, promotes apoptosis, and increases cellular radiosensitivity. +lncRNA target 34903127 hsa-mir-513a Cholangiocarcinoma Furthermore, we showed that miR-513a-5p is a regulator of CCA by targeting SFN. +lncRNA target 34903122 hsa-mir-23b Osteosarcoma Thus, miR-23b-3p augmented the viability, proliferation, and migration of OS cells by directly targeting and downregulating VEPH1, which inhibited the activation of the PI3K/AKT signaling pathway. +genetics_knock down_promote 34901459 hsa-mir-335 Osteosarcoma MYH9 overexpression overturned miR +target gene 34901392 hsa-mir-885 Stomach Neoplasms Circular RNA circRAB31 acts as a miR-885-5psponge to suppress gastric cancer progressionvia the PTEN/PI3K/AKT pathway. +lncRNA target 34901284 hsa-mir-218 Squamous Cell Carcinoma of Head and Neck Additionally, we found that hsa_circ_0023305-mediated upregulation of TRPM7 inhibited miR +other 34901272 hsa-mir-153 Cerebral Infarction, Acute CONCLUSION: miR-210, miR-137, and miR-153 have a certain value in the diagnosis and prediction of 1-year death of acute cerebral infarction and may be potential diagnostic and predictive indicators. +other 34901272 hsa-mir-137 Cerebral Infarction, Acute CONCLUSION: miR-210, miR-137, and miR-153 have a certain value in the diagnosis and prediction of 1-year death of acute cerebral infarction and may be potential diagnostic and predictive indicators. +other 34901272 hsa-mir-210 Cerebral Infarction, Acute CONCLUSION: miR-210, miR-137, and miR-153 have a certain value in the diagnosis and prediction of 1-year death of acute cerebral infarction and may be potential diagnostic and predictive indicators. +circulation_biomarker_diagnosis_ns 34901270 hsa-mir-21 Depression RESULTS: MiR-21 and FGF1 with increased expression could protect the cardiac function of model rats and improve their diastolic blood pressure (DBP), systolic blood pressure (SBP), heart rate (HR), coronary flow (CF), bax, and bcl-2 levels, but it would also cause further increase of vascular endothelial growth factor (VEGF) and decreased infarct size (INF). +genetics_overexpression_promote 34901263 hsa-mir-34a Carcinoma, Non-Small-Cell Lung TNFAIP8 was a functional gene of miR-34a-5p, and the suppressive effects of miR-34a-5p overexpression on DDP-resistant NSCLC progression were dependent on the suppression of TNFAIP8. +target gene 34900997 hsa-mir-206 Histiocytoma, Malignant Fibrous High Expression MicroRNA-206 Inhibits the Growth of Tumor Cells in Human Malignant Fibrous Histiocytoma. +genetics_overexpression_promote 34900992 hsa-mir-3150a Prostatic Neoplasms Importantly, miR-3150a-3p overexpression was related to the increased proliferation and decreased apoptosis of PCa cells. +other 34900814 hsa-mir-135a Diabetes Mellitus, Type 2 miR-135a expression was considerably higher by 4.7-fold in T(2)D compared to the control group (1.8-fold) (p < 0.001) while the miR126 expression was significantly decreased by 3.9-fold in T(2)D compared to the controls (6.3-fold) (p < 0.001). +other 34900814 hsa-mir-126 Diabetes Mellitus, Type 2 CONCLUSIONS: The results of this case and control study showed that miR-135a and miR126 expression in saliva fluid as a reliable biomarkers and non-invasive approach in combination by change of lipid profiles, glucose and HbA1c may be used to monitor diabetic and non-diabetic patients, while further research is needed to investigate the relationship of these salivary miRNAs (miR135a, miR126) levels change on shifting the levels of clinical laboratory outcomes. +other 34900811 hsa-mir-145 Diabetes Mellitus This study intended to study the effects of eight weeks of moderate and high intensity aerobic training (MIT&HIT) on the mRNA of Mir-145, Wnt3a, and Dab2 in heart tissue of type 2 diabetic rats. RESULTS: Moderate and high intensity aerobic training was associated with non-significant increase in Mir-145 mRNA of Heart tissue in type 2 diabetic rats than the diabetic control group(P < 0.05). +lncRNA target 34900737 hsa-mir-155 Carcinoma, Non-Small-Cell Lung Finally, high levels of miR-155 in the cachectic group lead to negative feedback inhibition of both SOCS1 and Foxp3 in both the pancreatic and NSCL cancer patients. +transcription factor target 34900727 hsa-mir-216a Adenocarcinoma of Lung Interfering with miR-216a-5p expression and activating the JAK2/STAT3 signaling pathway can significantly reverse LNT inhibitory effects on LUAD. Collectively, LNT can inhibit the JAK2/STAT3 signaling pathway by up-regulating miR-216a-5p, reducing stemness, and promoting LUAD cells apoptosis, then slow down LUAD occurrence and development, providing concepts and experimental foundation treating patients with LUAD. +circulation_biomarker_diagnosis_up 34900665 hsa-mir-1204 Carcinoma, Hepatocellular Additionally, circ_0000098 was mainly distributed in the cytoplasm of HCC cells, and up-regulated ALX4 expression through competitively decoying miR-1204. CONCLUSION: Circ_0000098, as a competitive endogenous RNA (ceRNA) of miR-1204, upregulates ALX4 expression and suppresses the growth, migration, invasion, and EMT of HCC cells. +circulation_biomarker_diagnosis_up 34900532 hsa-mir-21 Brain Injuries, Traumatic Low levels of exosome-miR-21 in the brain can effectively improve neuroinflammation and blood-brain barrier (BBB) permeability, reduce nerve apoptosis, restore neural function and ameliorate TBI. +genetics_overexpression_promote 34900520 hsa-mir-21 Anodontia After overexpressing miR +transcription factor target 34900201 hsa-mir-20 Acute Lung Injury CONCLUSIONS: miR-204 participates in the protection of HA acute lung injury by targeting FOXK2. +transcription factor target 34900201 hsa-mir-204 Acute Lung Injury CONCLUSIONS: miR-204 participates in the protection of HA acute lung injury by targeting FOXK2. +other 34900149 hsa-mir-222 Hepatitis B, Chronic Further studies should be conducted to confirm whether miR-222 can be a biomarker for prognosis of severe liver diseases. +genetics_knock down_suppress 34900056 hsa-mir-186 Stomach Neoplasms In particular, OIP5-AS1 may function as a ceRNA for miR-186, and inhibition of miR-186 blocks the effects of OIP5-AS1 knockdown on aerobic glycolysis in GC cells. +circulation_biomarker_diagnosis_ns 34900055 hsa-mir-16 polycystic kidney disease 3 MiR5p was selected as the best circulating biomarker of ADPKD. +target gene 34899909 hsa-mir-296 Carcinoma, Hepatocellular In Hepatocellular Carcinoma, miRNA-296-3p Targets MSL2 and Suppresses Cell Proliferation and Invasion. +circRNA target 34899908 hsa-mir-139 Pancreatic Carcinoma CONCLUSION: CircRNF13 serves as a competitive endogenous RNA of IGF1R to inhibit the function of miR +genetics_overexpression_promote 34899906 hsa-mir-145 Prostatic Neoplasms 5p overexpression on PCa were studied using cell proliferation, migration, and invasion experiments. +circulation_biomarker_diagnosis_ns 34899857 hsa-mir-92a Lymphoma, Non-Hodgkin 92 cluster host gene and the TET2 gene and correlated them with the expression levels of TET2 mRNA and miR-92a-3p and miR-92a-5p mature miRNAs in NHL cell lines, tumour samples, and the whole blood gDNA of an NHL case control cohort. +genetics_overexpression_suppress 34899853 hsa-mir-1205 Stomach Neoplasms MiR-1205 overexpression restrained the resistance of DDP-resistant GC cells to DDP, but FGFR1 elevation abated the effect. +circulation_biomarker_diagnosis_ns 34899827 hsa-mir-1233 Ovarian Neoplasms By using LASSO and Elastic Net as embedded algorithms of feature selection techniques, the present study identified 10 miRNAs that were regulated in ovarian serum cancer samples compared to non-cancer samples in public available dataset GSE106817: hsa-miR-5100, hsa-miR +circulation_biomarker_diagnosis_ns 34899827 hsa-mir-4532 Ovarian Neoplasms By using LASSO and Elastic Net as embedded algorithms of feature selection techniques, the present study identified 10 miRNAs that were regulated in ovarian serum cancer samples compared to non-cancer samples in public available dataset GSE106817: hsa-miR-5100, hsa-miR +circulation_biomarker_diagnosis_ns 34899827 hsa-mir-5100 Ovarian Neoplasms By using LASSO and Elastic Net as embedded algorithms of feature selection techniques, the present study identified 10 miRNAs that were regulated in ovarian serum cancer samples compared to non-cancer samples in public available dataset GSE106817: hsa-miR-5100, hsa-miR +circulation_biomarker_diagnosis_ns 34899827 hsa-mir-184 Ovarian Neoplasms By using LASSO and Elastic Net as embedded algorithms of feature selection techniques, the present study identified 10 miRNAs that were regulated in ovarian serum cancer samples compared to non-cancer samples in public available dataset GSE106817: hsa-miR-5100, hsa-miR +circulation_biomarker_diagnosis_ns 34899827 hsa-mir-4787 Ovarian Neoplasms By using LASSO and Elastic Net as embedded algorithms of feature selection techniques, the present study identified 10 miRNAs that were regulated in ovarian serum cancer samples compared to non-cancer samples in public available dataset GSE106817: hsa-miR-5100, hsa-miR +circulation_biomarker_diagnosis_ns 34899827 hsa-mir-20b Ovarian Neoplasms By using LASSO and Elastic Net as embedded algorithms of feature selection techniques, the present study identified 10 miRNAs that were regulated in ovarian serum cancer samples compared to non-cancer samples in public available dataset GSE106817: hsa-miR-5100, hsa-miR +circulation_biomarker_diagnosis_ns 34899827 hsa-mir-6800 Ovarian Neoplasms By using LASSO and Elastic Net as embedded algorithms of feature selection techniques, the present study identified 10 miRNAs that were regulated in ovarian serum cancer samples compared to non-cancer samples in public available dataset GSE106817: hsa-miR-5100, hsa-miR +circulation_biomarker_diagnosis_ns 34899827 hsa-mir-1228 Ovarian Neoplasms By using LASSO and Elastic Net as embedded algorithms of feature selection techniques, the present study identified 10 miRNAs that were regulated in ovarian serum cancer samples compared to non-cancer samples in public available dataset GSE106817: hsa-miR-5100, hsa-miR +circulation_biomarker_diagnosis_ns 34899827 hsa-mir-1290 Ovarian Neoplasms By using LASSO and Elastic Net as embedded algorithms of feature selection techniques, the present study identified 10 miRNAs that were regulated in ovarian serum cancer samples compared to non-cancer samples in public available dataset GSE106817: hsa-miR-5100, hsa-miR +circulation_biomarker_diagnosis_ns 34899827 hsa-mir-4783 Ovarian Neoplasms By using LASSO and Elastic Net as embedded algorithms of feature selection techniques, the present study identified 10 miRNAs that were regulated in ovarian serum cancer samples compared to non-cancer samples in public available dataset GSE106817: hsa-miR-5100, hsa-miR +transcription factor target 34899681 hsa-mir-221 Acute Lung Injury 5p targets JNK2 and thereby aggravates lung inflammation and injury during sepsis. +circulation_biomarker_diagnosis_up 34899574 hsa-mir-210 Carotid Stenosis Methods: Circulating levels of vascular-enriched miR-92a, miR-126, miR-143, miR-145, miR-155, miR-210, miR-221, miR-222, and miR +circulation_biomarker_diagnosis_up 34899574 hsa-mir-92a Carotid Stenosis Methods: Circulating levels of vascular-enriched miR-92a, miR-126, miR-143, miR-145, miR-155, miR-210, miR-221, miR-222, and miR +circulation_biomarker_diagnosis_up 34899574 hsa-mir-145 Carotid Stenosis Methods: Circulating levels of vascular-enriched miR-92a, miR-126, miR-143, miR-145, miR-155, miR-210, miR-221, miR-222, and miR +circulation_biomarker_diagnosis_up 34899574 hsa-mir-143 Carotid Stenosis Methods: Circulating levels of vascular-enriched miR-92a, miR-126, miR-143, miR-145, miR-155, miR-210, miR-221, miR-222, and miR +other 34899562 hsa-mir-29a Parkinson Disease Conclusion: The miRNA combination of salivary miR-29a-3p and miR-29c-3p has potential to be a diagnostic biomarker for idiopathic PD. +other 34899562 hsa-mir-29c Parkinson Disease Conclusion: The miRNA combination of salivary miR-29a-3p and miR-29c-3p has potential to be a diagnostic biomarker for idiopathic PD. +circulation_biomarker_diagnosis_ns 34899022 hsa-mir-129 Fatty Liver 5p, in goose fatty liver was also significantly higher than that in normal liver (P<0.05), suggesting that these blood miRNAs are released from goose fatty liver. +lncRNA target 34898474 hsa-mir-432 Cholangiocarcinoma The promoting effect of circ-ZNF609 on cholangiocarcinoma is achieved via oncogene LRRC1 up-regulation through targeting miR +lncRNA target 34898380 hsa-let-7d Lung Neoplasms Huaier/let-7d-5p/NAP1L1 axis is supposed to be a promising target for the treatment of angiogenesis and tumor growth in LC via elevated let-7d-5p and targeted NAP1L1. +other 34898376 hsa-mir-4435-2 Squamous Cell Carcinoma of Head and Neck WGCNA and Kaplan-Meier survival analysis revealed that 5 DELs (MIR4435-2 HG, CASC9, LINC01980, STARD4-AS1 and MIR99AHG) were significantly correlated with OS of HNSCC patients, whereas DEL PART1 was most significantly correlated with the HNSCC tumor. The in silico predicted expression patterns of PART1, LINC01980 and MIR4435-2 HG were further validated in HNSCC cell lines and patient sera. +exosome 34898374 hsa-mir-93 Wounds and Injuries Collectively, the results indicate that BMSC-derived exosomes promote skin wound healing via the miR3p/APAF1 axis. +circulation_biomarker_diagnosis_ns 34898373 hsa-mir-590 Diabetic Nephropathies Serum miR +lncRNA target 34898365 hsa-mir-369 Osteoarthritis 3p/JAK2/STAT3 signaling pathway to accelerate the viability, and inhibit inflammation and cell apoptosis in OA chondrocytes. +other 34898362 hsa-mir-378b Fatty Liver This study aims to clarify the biological function of microRNA-378b (miR-378b) in ethanol (EtOH)-induced hepatic lipid accumulation. +lncRNA target 34898360 hsa-mir-146 Kidney Diseases It can be seen that the expression of miR-146 inhibits inflammatory factors, apoptosis, oxidative stress and NF- kappa the activation of B pathway promotes the repair of renal injury in CPB rats. +circulation_biomarker_diagnosis_ns 34898354 hsa-mir-127 Aortic Aneurysm, Abdominal 5p/NCK-associated protein 1-like axis The long non-coding RNA plasmacytoma variant translocation 1 (lncRNA PVT1) has been implicated in the progression of abdominal aortic aneurysms (AAA). +genetics_overexpression_suppress 34898351 hsa-mir-582 Stomach Neoplasms 3p inhibition or DIXDC1 overexpression could reverse the above-mentioned effects of knocking down circ_0000423 on GC cells. +lncRNA target 34898169 hsa-mir-27a Breast Neoplasms We selected oncogenic microRNA-27a (miR-27a) for further study as a lead molecule binds its Drosha site and a nearby internal loop, affording a homodimer that potently and specifically inhibits miR-27a processing in both breast cancer and prostate cancer cells. +other 34897970 hsa-mir-141 Cardiotoxicity However, the role of miR3p in myocardial lipotoxicity remains elusive. +transcription factor target 34897970 hsa-mir-141 Cardiomyopathies In conclusion, the present study demonstrates that miR3p regulates saturated fatty acid-induced cardiomyocyte apoptosis through Notch1/PTEN/AKT pathway via targeting PSEN1, which gains a new insight into the mechanisms of myocardial lipotoxic injury. +transcription factor target 34897970 hsa-mir-141 Hyperlipidemias 3p regulates saturated fatty acid-induced cardiomyocyte apoptosis through Notch1/PTEN/AKT pathway via targeting PSEN1, which gains a new insight into the mechanisms of myocardial lipotoxic injury. +other 34897970 hsa-mir-141 Obesity It has been reported that miR3p levels are markedly upregulated in the cardiomyocytes of obese rats induced by a high-fat diet. +exosome 34897628 hsa-mir-124 Brain Injuries 3p expression is enhanced in microglia-derived exosomes following TBI, with this miRNA being capable of promoting neural repair after such injury. +genetics_overexpression_promote 34897468 hsa-mir-204 Thyroid Cancer, Papillary Several microRNAs (miRs) targeting nodes in the transforming growth factor beta (TGFbeta)-SMAD pathway, miR-204, miR-205, and miR-144, were overexpressed in the BRAF-TDShi group. +genetics_overexpression_promote 34897468 hsa-mir-205 Thyroid Cancer, Papillary Several microRNAs (miRs) targeting nodes in the transforming growth factor beta (TGFbeta)-SMAD pathway, miR-204, miR-205, and miR-144, were overexpressed in the BRAF-TDShi group. +circulation_biomarker_diagnosis_up 34897278 hsa-mir-184 Myocardial Infarction Thus, miR-184 is a circulating biomarker of AFD that changes after ERT. +circulation_biomarker_diagnosis_up 34897278 hsa-mir-184 Fabry Disease Thus, miR-184 is a circulating biomarker of AFD that changes after ERT. +transcription factor target 34897031 hsa-mir-338 Glioma We acquired miR5p, which suppresses the development of glioma, from the GEO and CGGA databases. +other 34896914 hsa-mir-105 Prostatic Neoplasms CONCLUSIONS: LINC00184 promoted docetaxel resistance and immune escape in prostate cancer cells by adsorption of miR5p, resulted in upregulation of the expression of PD-L1. +genetics_overexpression_promote 34896865 hsa-mir-494 Squamous Cell Carcinoma of Head and Neck In addition, NR2F2-AS1 silencing increased OSCC cell proliferation rate while overexpression of miR-494 and NR2F2-AS1 decreased OSCC cell proliferation. +lncRNA target 34896788 hsa-mir-216b Carcinoma, Non-Small-Cell Lung TargetScan analysis manifested that miR-216b, targeted by MALAT1, was down-regulated in NSCLC cells. +circulation_biomarker_diagnosis_up 34895840 hsa-mir-144 Alzheimer Disease Circulating miR +genetics_overexpression_promote 34895074 hsa-mir-128 Glioblastoma 3p as a tumor-suppressor whose overexpression restored the sensitivity of TMZ in GBM cells. +lncRNA target 34895065 hsa-mir-5195 Carcinoma, Hepatocellular 3p and transcription factor forkhead box O1 (FOXO1) to identify a novel target for HCC treatment. +circulation_biomarker_diagnosis_up 34895055 hsa-mir-1255b Prostatic Neoplasms The measurement of miR-1255b-5p in blood may provide a new noninvasive approach for the diagnosis of prostate cancer. +lncRNA target 34895052 hsa-mir-27b Neurogenic Inflammation These data revealed that miR-27b-3p could mediate not only microglia activation but also neuroinflammation via downregulating A20 expression. +other 34895052 hsa-mir-27b Spinal Cord Injuries Thus, miR-27b-3p is regarded as gene therapy in treating cerebral hemorrhage and spinal cord injury. +other 34895052 hsa-mir-27b Cerebral Hemorrhage Thus, miR-27b-3p is regarded as gene therapy in treating cerebral hemorrhage and spinal cord injury. +lncRNA target 34895051 hsa-mir-378 Osteoporosis-pseudoglioma syndrome HOTAIR negatively regulates miR-378g by targeting NNMT.HOTAIR is an miR-378g sponge that targets NNMT, inhibits the osteogenic differentiation of BMSCs, and provides a valuable target for the treatment of OP. +genetics_overexpression_promote 34895048 hsa-mir-98 Uterine Cervical Neoplasms Overexpression miR +transcription factor target 34895047 hsa-mir-187 Cardiovascular Diseases It is suggested that miR3p may be an important target for CTS participate in the process of cardiovascular disease.[Figure: see text]. +genetics_overexpression_suppress 34895046 hsa-mir-144 Breast Neoplasms Overexpression of miR-144 can reduce drug resistance in breast cancer cells by inhibiting autophagy or targeting DNAJC3-AS1 for downregulation. +lncRNA target 34895044 hsa-mir-20b Inflammatory Bowel Diseases Collectively, our findings revealed that M2-EVs carrying MEG3 enhanced UC cell viability and reduced inflammatory responses via the miR-20b-5p/CREB1 axis, thus alleviating UC inflammation. +genetics_overexpression_promote 34895042 hsa-mir-19a Leukemia, Myeloid, Acute Overexpression of miR-19a-3p had the opposite effect in AML cells, suggesting simvastatin-inhibited AML by reducing miR-19a-3p expression. +circulation_biomarker_diagnosis_up 34895039 hsa-mir-496 Endometrial Neoplasms phenylindole; DMEM: Dulbecco's minimal essential medium/Ham's; ECL: enhanced chemiluminiscent; ELISA: Enzyme-Linked Immunosorbent Assay; EMT: epithelial-mesenchymal transition; FBS: fetal bovine serum; FISH:Fluorescence in situ hybridization; FITC:fluorescein isothiocyanate; FSP:fibroblast-specific protein; GAPDH: glyceraldehyde +circRNA target 34894939 hsa-mir-1248 Pre-Eclampsia CONCLUSION: GNB5 and IL2RB might be key genes involved in the PI3K-Akt signalling pathway in PE, and hsa_circ_0087208, hsa_circ_0035443, hsa_circ_0067557 and hsa_circ_0052661 might regulate these key genes in PE by binding miR-1248 or miR-4303.Key messagesThere is still a lack of predictive and diagnostic factors for preeclampsia, which is a common cause of maternal death worldwide.This study identified a novel circRNA-associated ceRNA network and related pathways in preeclampsia.GNB5 and IL2RB might be key genes in their related circRNA-associated ceRNA network, and probably take an important role in preeclampsia via PI3K-Akt signalling pathway, which made them to be potential markers of preeclampsia. +circRNA target 34894939 hsa-mir-4303 Pre-Eclampsia CONCLUSION: GNB5 and IL2RB might be key genes involved in the PI3K-Akt signalling pathway in PE, and hsa_circ_0087208, hsa_circ_0035443, hsa_circ_0067557 and hsa_circ_0052661 might regulate these key genes in PE by binding miR-1248 or miR-4303.Key messagesThere is still a lack of predictive and diagnostic factors for preeclampsia, which is a common cause of maternal death worldwide.This study identified a novel circRNA-associated ceRNA network and related pathways in preeclampsia.GNB5 and IL2RB might be key genes in their related circRNA-associated ceRNA network, and probably take an important role in preeclampsia via PI3K-Akt signalling pathway, which made them to be potential markers of preeclampsia. +other 34894715 hsa-mir-1 Colorectal Neoplasms Aims: To study the association between miR-31 expression and clinical outcomes in colorectal cancer. +other 34894598 hsa-mir-21 Breast Neoplasms A dual-mode electrochemical biosensor is successfully developed for simultaneous detection of two different kinds of breast cancer biomarkers, namely cancer antigen 15-3 (CA 15-3) and microRNA-21 (miRNA-21), for the first time. +circulation_biomarker_prognosis_ns 34894384 hsa-mir-503 Squamous Cell Carcinoma of Head and Neck 3p-BAK axis may be a therapeutic target and that circulating miR +other 34893896 hsa-mir-160 Dehydration Our study revealed the mechanisms by which the positive feedback loop of Mdm-miR160-MdARF17-MdHYL1 influences apple drought tolerance. +genetics_overexpression_promote 34893101 hsa-mir-146a Precursor Cell Lymphoblastic Leukemia-Lymphoma CONCLUSION: Plasma miR-146a is overexpressed and miR-223 is low-expressed in children with ALL, the abnormal expression of the two factors is related to the prognosis of children with ALL. +genetics_overexpression_promote 34893101 hsa-mir-223 Precursor Cell Lymphoblastic Leukemia-Lymphoma CONCLUSION: Plasma miR-146a is overexpressed and miR-223 is low-expressed in children with ALL, the abnormal expression of the two factors is related to the prognosis of children with ALL. +other 34893096 hsa-mir-143 Leukemia CONCLUSION: Expression of miR-143 in AML patients is lower than that in normal controls. +other 34893064 hsa-mir-224 Esophageal Squamous Cell Carcinoma 3p. +genetics_knock down_promote 34892984 hsa-mir-27a Obesity CONCLUSION: We found that EA could regulate miRNA27a-mediated autophagy-related proteins and promote white fat browning, which may contribute to weight loss. +circulation_biomarker_diagnosis_ns 34891212 hsa-mir-26a Diabetic Nephropathies Besides, serum miR-26a-5p was diminished in DN patients, and luciferase reporter gene revealed that miR-26a-5p is direct target of SNHG5. These results indicated that inhibition of SNHG5 may mitigate HG-induced renal tubular damage via targeting miR-26a-5p, which providing a new insight into the mechanism of renal tubule damage in DN patients. +genetics_overexpression_suppress 34891100 hsa-mir-149 Squamous Cell Carcinoma of Head and Neck 3p-mediated decrease in metastasis was reversed by overexpression of MMP2 in OSCC cells. +genetics_overexpression_promote 34891002 hsa-mir-7 Osteoarthritis In our previous findings, we demonstrated that overexpression of miR-7 was found in OA and promoted OA development. +circulation_biomarker_diagnosis_ns 34890883 hsa-mir-125b Alzheimer Disease Furthermore, it identified AD patients from healthy controls by measuring the levels of exosomal miRNA-125b, miRNA-15a, and miRNA-361 in clinical serum samples. +circulation_biomarker_diagnosis_ns 34890883 hsa-mir-15a Alzheimer Disease Furthermore, it identified AD patients from healthy controls by measuring the levels of exosomal miRNA-125b, miRNA-15a, and miRNA-361 in clinical serum samples. +circulation_biomarker_diagnosis_ns 34890883 hsa-mir-361 Alzheimer Disease Furthermore, it identified AD patients from healthy controls by measuring the levels of exosomal miRNA-125b, miRNA-15a, and miRNA-361 in clinical serum samples. +transcription factor target 34890627 hsa-mir-181a Papilloma, Choroid Plexus To identify targets for chemoprevention, we previously reported a cross-species analysis to identify the transcriptional drivers of cSCC development and identified miR-181a as a potential oncomiR. +circulation_biomarker_diagnosis_up 34889994 hsa-let-7a Ovarian Neoplasms In urine, miR-15a was upregulated whereas let-7a was down-regulated in ovarian cancer patients. Especially, miR-15a and let-7a qualify for possible circulating biomarkers in liquid biopsies of ovarian cancer patients. +circulation_biomarker_diagnosis_up 34889994 hsa-mir-15a Ovarian Neoplasms In urine, miR-15a was upregulated whereas let-7a was down-regulated in ovarian cancer patients. Especially, miR-15a and let-7a qualify for possible circulating biomarkers in liquid biopsies of ovarian cancer patients. +genetics_GWAS 34889890 hsa-mir-128a Diabetes Mellitus, Type 2 In this study we investigated the associations of the VEGF-2578 C/A (rs699947), VEGF-2549 insertion/deletion (I/D), and ACE I/D rs4646994 and Mir128a (rs11888095) gene variations with T2D using the amplification refractory mutation system PCR (ARMS-PCR) and mutation specific PCR (MSP). +lncRNA target 34889712 hsa-mir-665 Neuroblastoma Together, our data demonstrated that lncRNA NHEG1 serves as a competitive partner to negatively regulate the activity of miR-665, which relieves the inhibition on HMGB1 expression and promotes the aggressive phenotype of neuroblastoma cells. Our study indicates that lncRNA NHEG1/miR-665/HMGB1 axis may play an important role in regulating the aggressiveness and the progression of neuroblastoma. +other 34889689 hsa-mir-338 Urinary Bladder Neoplasms 3p/ETS1/PI3K/AKT pathway is involved in regulating BC progression. +lncRNA target 34889164 hsa-mir-21 Breast Neoplasms These results suggest that lncRNA CASC7 suppresses to malignant behaviors of breast cancer by modulating miR5p/FASLG axis. +genetics_overexpression_promote 34888946 hsa-mir-100 Lymphoma, Large B-Cell, Diffuse CONCLUSION: HAGLROS overexpression contributes to DLBCL development and poor prognosis via targeting miR-100, which could be a potential prognostic biomarker and therapeutic target for DLBCL patients. +genetics_knock down_promote 34888746 hsa-mir-103 spondyloepimetaphyseal dysplasia, Strudwick type Knockdown of miRNA-103 displayed similar effects as knockdown of HIF-1alpha in ASM cells under hypoxia, while overexpression of miRNA-103 played the opposite role. +genetics_knock down_promote 34888652 hsa-mir-145 Carcinoma, Non-Small-Cell Lung Furthermore, overexpression of miR-145 could sensitize radioresistant NSCLC cells to IR, whereas knockdown of miR-145 in NSCLC cells acted the converse manner. +other 34888382 hsa-mir-23a Periodontitis CONCLUSION: Saliva miR-23a and miR-146a can be used as biomarkers for the diagnosis and assessment of periodontitis, and they may have regulatory relationships with IL-1beta, IL-6, and IL-17. +other 34888382 hsa-mir-146a Periodontitis CONCLUSION: Saliva miR-23a and miR-146a can be used as biomarkers for the diagnosis and assessment of periodontitis, and they may have regulatory relationships with IL-1beta, IL-6, and IL-17. +genetics_GWAS 34888351 hsa-mir-15a Liver Injury In summary, our results identified hsa-miR-15a-3p as a novel epigenetic factor modulating NAT2 expression and as a protective module against INH-induced liver injury, and provided new clues to elucidate the epigenetic regulatory mechanisms concerning drug-induced liver injury (DILI). +target gene 34888223 hsa-mir-146a Colorectal Neoplasms miR-146a-5p and miR-193a-5p Synergistically Inhibited the Proliferation of Human Colorectal Cancer Cells (HT-29 cell line) through ERK Signaling Pathway. +other 34888219 hsa-mir-221 Myocardial Infarction 3p as informative biomarkers and positively correlated with artery stenosis in MI. +other 34888219 hsa-mir-1 Myocardial Infarction 3p as informative biomarkers and positively correlated with artery stenosis in MI. +genetics_overexpression_promote 34888137 hsa-mir-33a Carcinoma, Non-Small-Cell Lung miRNA-33a-5p overexpressed in LUSC was supported by 706 LUSC and 261 non-LUSC samples gathering from RT-qPCR, miRNA-seq, and public miRNA microarrays. +transcription factor target 34887931 hsa-mir-24 Non-alcoholic Fatty Liver Disease It likely acts by altering miRNA-24 expression and regulating the target TRPM4 protein pathway to achieve NAFLD treatment. +circRNA target 34887753 hsa-mir-1291 Liver Cirrhosis In conclusion, our current results reveal a novel mechanism by which circCREBBP alleviates liver fibrosis by targeting the hsa-miR-1291/LEFTY2 axis, and also suggest that circCREBBP may be a potential biomarker for heart failure. +other 34887672 hsa-mir-197 Non-alcoholic Fatty Liver Disease The HCG18-miR3p axis exerted effects on the progression of fat sedimentation and glucose disorder in NAFLD. +other 34887647 hsa-mir-26a Pancreatitis 5p and miR-762. +other 34887647 hsa-mir-92b Pancreatitis 5p and miR-762. +other 34887647 hsa-mir-24 Pancreatitis 5p and miR-762. +other 34887647 hsa-mir-762 Pancreatitis 5p and miR-762. +other 34887647 hsa-mir-216b Pancreatitis 5p and miR-762. +circulation_biomarker_diagnosis_ns 34887646 hsa-mir-192 Acute Lung Injury We established serum sEV miRNA signatures for ALI and CLI and a panel of miRNAs (miR +circulation_biomarker_diagnosis_ns 34887646 hsa-mir-122 Acute Lung Injury We established serum sEV miRNA signatures for ALI and CLI and a panel of miRNAs (miR +genetics_GWAS 34887601 hsa-mir-370 Depressive Disorder The objective of the study was to evaluate the impact of 1846G>A polymorphism of the CYP2D6 gene on the concentration/dose indicator of phenazepam, using findings on enzymatic activity of CYP2D6 (as evaluated by the 6M-THBC/pinoline ratio measurement) and on CYP2D6 expression level obtained by measuring the hsa-miR3p plasma concentration levels in patients suffering from major depressive disorder. +other 34887515 hsa-mir-1246 Cardiovascular Diseases Supermeres are highly enriched with cargo involved in multiple cancers (glycolytic enzymes, TGFBI, miR-1246, MET, GPC1 and AGO2), Alzheimer's disease (APP) and cardiovascular disease (ACE2, ACE and PCSK9). +other 34887515 hsa-mir-1246 Alzheimer Disease Supermeres are highly enriched with cargo involved in multiple cancers (glycolytic enzymes, TGFBI, miR-1246, MET, GPC1 and AGO2), Alzheimer's disease (APP) and cardiovascular disease (ACE2, ACE and PCSK9). +circulation_biomarker_diagnosis_up 34887498 hsa-mir-455 Liver Neoplasms Increased serum levels of miR +circulation_biomarker_diagnosis_up 34887498 hsa-mir-122 Liver Neoplasms Increased serum levels of miR +circulation_biomarker_diagnosis_up 34887498 hsa-mir-122 Diabetes Mellitus, Type 2 Increased serum levels of miR +circulation_biomarker_diagnosis_up 34887498 hsa-mir-455 Diabetes Mellitus, Type 2 Increased serum levels of miR +lncRNA target 34887384 hsa-mir-188 Ovarian Neoplasms, High-Grade Serous Collectively, these results reveal a novel ETV5/lncRNA CTBP1-DT/miR5p/MAP3K3 pathway for HGSOC progression and suggest that lncRNA CTBP1-DT might be a potential biomarker and therapeutic target for HGSOC. +lncRNA target 34887365 hsa-mir-29a Cardiomyopathies The aim of this study was to investigating whether lncRNA H19 promotes myocardial fibrosis by suppressing the miR-29a-3p/miR-29b-3p-VEGFA/TGF-beta axis. +lncRNA target 34887365 hsa-mir-29b Cardiomyopathies The aim of this study was to investigating whether lncRNA H19 promotes myocardial fibrosis by suppressing the miR-29a-3p/miR-29b-3p-VEGFA/TGF-beta axis. +circulation_biomarker_diagnosis_up 34887365 hsa-mir-29a Atrial Fibrillation Serum expression of lncRNA H19 was negatively correlated with the expression of miR-29a-3p and miR-29b-3p among patients with AF (r(s) = -0.337, r(s) = -0.236). +circulation_biomarker_diagnosis_up 34887365 hsa-mir-29b Atrial Fibrillation Serum expression of lncRNA H19 was negatively correlated with the expression of miR-29a-3p and miR-29b-3p among patients with AF (r(s) = -0.337, r(s) = -0.236). +lncRNA target 34887360 hsa-mir-21 Atherosclerosis CASC7 inhibited proliferation and enhanced the apoptosis of VSMC through modulating the miR-21/PI3K-AKT axis, and upregulating CASC7 suppressed the inflammatory response of HUVEC by sponging miR-21 to inhibit the TLR4/NF-kappaB signal pathway. +lncRNA target 34887123 hsa-mir-214 Keloid In summary, lnc-H19 may exert regulatory functions in KD by targeting miR +lncRNA target 34887123 hsa-mir-214 Mucocutaneous Lymph Node Syndrome In summary, lnc-H19 may exert regulatory functions in KD by targeting miR +circulation_biomarker_diagnosis_ns 34886843 hsa-let-7b Depressive Disorder, Major CONCLUSIONS: These findings show that lower plasma levels of let-7b-5p are associated with a higher future risk of MDD. +other 34885115 hsa-mir-21 Carcinoma, Non-Small-Cell Lung The MEK/ERK/miR-21 Signaling Is Critical in Osimertinib Resistance in EGFR-Mutant Non-Small Cell Lung Cancer Cells. +target gene 34885090 hsa-mir-195 Breast Neoplasms MiR-195 and Its Target SEMA6D Regulate Chemoresponse in Breast Cancer. +epigenetics 34885060 hsa-mir-129-2 Colorectal Neoplasms We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis. +epigenetics 34885060 hsa-mir-137 Colorectal Neoplasms We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis. +epigenetics 34885060 hsa-mir-34b Colorectal Neoplasms We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis. +epigenetics 34885060 hsa-mir-548i Colorectal Neoplasms We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis. +epigenetics 34885060 hsa-mir-19a Colorectal Neoplasms We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis. +epigenetics 34885060 hsa-mir-548f Colorectal Neoplasms We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis. +epigenetics 34885060 hsa-mir-548g Colorectal Neoplasms We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis. +epigenetics 34885060 hsa-mir-124 Colorectal Neoplasms We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis. +epigenetics 34885060 hsa-mir-124-2 Colorectal Neoplasms We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis. +epigenetics 34885060 hsa-mir-9 Colorectal Neoplasms We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis. +epigenetics 34885060 hsa-mir-1204 Colorectal Neoplasms We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis. +epigenetics 34885060 hsa-mir-17 Colorectal Neoplasms We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis. +epigenetics 34885060 hsa-mir-18a Colorectal Neoplasms We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis. +epigenetics 34885060 hsa-mir-34c Colorectal Neoplasms We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis. +epigenetics 34885060 hsa-mir-20a Colorectal Neoplasms We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis. +epigenetics 34885060 hsa-mir-19b Colorectal Neoplasms We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis. +epigenetics 34885060 hsa-mir-762 Colorectal Neoplasms We found 18 miR genes to be significantly differentially methylated, with MIR124-2, MIR124-3, MIR129-2, MIR137, MIR34B, MIR34C, MIR548G, MIR762, and MIR9-3 hypermethylated and MIR1204, MIR17, MIR17HG, MIR18A, MIR19A, MIR19B1, MIR20A, MIR548F5, and MIR548I4 hypomethylated in CRC tumor compared with normal tissue, most of these miRs having been shown to regulate steps of metastasis. +genetics_knock down_promote 34884984 hsa-mir-214 Prostatic Neoplasms Knockdown of miR-214 increased the expression of its target protein, Protein Tyrosine Kinase 6 (PTK6), a kinase shown to promote oncogenic signaling and tumorigenesis in PCa. +transcription factor target 34884968 hsa-mir-34a Non-alcoholic Fatty Liver Disease Our results suggest that 5-CQA alleviates lipid accumulation by downregulating miR-34a, leading to activation of the SIRT1/AMPK pathway. +transcription factor target 34884968 hsa-mir-34a Inflammation Our results suggest that 5-CQA alleviates lipid accumulation by downregulating miR-34a, leading to activation of the SIRT1/AMPK pathway. +circulation_biomarker_diagnosis_ns 34884950 hsa-mir-15a Multiple Myeloma 3p were observed in the CD138+ plasma cells of MM patients with osteolytic bone lesions, compared to those without. +circulation_biomarker_diagnosis_ns 34884950 hsa-mir-222 Multiple Myeloma 3p were observed in the CD138+ plasma cells of MM patients with osteolytic bone lesions, compared to those without. +circulation_biomarker_diagnosis_ns 34884950 hsa-mir-16 Multiple Myeloma 3p were observed in the CD138+ plasma cells of MM patients with osteolytic bone lesions, compared to those without. +circulation_biomarker_diagnosis_ns 34884950 hsa-mir-155 Multiple Myeloma 5p expression was significantly lower in the CD138+ plasma cells of MM patients than in those of sMM patients. +other 34884950 hsa-mir-223 Multiple Myeloma Furthermore, lower levels of miR3p were associated with significantly worse overall survival in MM patients. +lncRNA target 34884879 hsa-mir-143 Fibrosis MiR-143 play an important role in hepatocellular carcinoma and liver fibrosis via inhibiting hepatoma cell proliferation. +epigenetics 34884879 hsa-mir-143 Carcinoma, Hepatocellular In summary, we are the first to report the change in whole-genome methylation levels by miR +genetics_knock down_suppress 34884879 hsa-mir-143 Liver Diseases We found that methylated cytosines increased 0.19% in the miR-143 knock-out (KO) liver fed with high-fat diet (HFD), compared with the wild type (WT). +lncRNA target 34884671 hsa-mir-122 Lung Neoplasms 5p was selectively sorted and secreted into lung cancer EVs through binding to RNA-binding protein hnRNPA2B1. +other 34884541 hsa-mir-3927 Osteosarcoma Analysis of osteosarcoma cell lines identified that CCL4 promotes integrin alphavbeta3 expression and cell migration by activating the focal adhesion kinase (FAK), protein kinase B (AKT), and hypoxia inducible factor 1 subunit alpha (HIF-1alpha) signaling pathways, which can downregulate microRNA3p expression. +transcription factor target 34884487 hsa-mir-125b Squamous Cell Carcinoma of Head and Neck TCGA analysis confirmed that tumor-suppressive miR-125b-5p and miR5p were significantly downregulated in OSCC tissues. +transcription factor target 34884487 hsa-mir-140 Squamous Cell Carcinoma of Head and Neck TCGA analysis confirmed that tumor-suppressive miR-125b-5p and miR5p were significantly downregulated in OSCC tissues. +lncRNA target 34884485 14q32 cluster Hyperphenylalaninemia with primapterinuria We hypothesized that CIRBP deficiency improves post-ischemic angiogenesis via downregulation of 14q32 microRNA expression. +genetics_overexpression_promote 34883316 hsa-mir-296 Colorectal Neoplasms 5p and ALO treatment both suppressed STAT3 expression, inhibited CRC cell proliferation, migration, invasion as well as the expressions of Bcl-2 and N-cadherin, but promoted apoptosis and expressions of Bax and E-cadherin, which were all reversed by overexpressed STAT3. +other 34882981 hsa-mir-156 Polythelia, Familial For this, we used the GA-induced grapevine parthenocarpy system to investigate the regulatory roles of VvmiR156a during this process. +lncRNA target 34882869 hsa-mir-21 Colorectal Neoplasms Overall, the current study's findings for the first time reveal that LOC100507144 could enhance CRC progression and metastasis through regulation of the CD44/Nanog/Sox2/miR-302/miR-21 axis. +other 34882856 hsa-mir-1271 Breast Neoplasms Overall, LINC02381 exerts carcinogenic effects in BC by the miR5p/FN1 axis to activate PI3K/AKT pathway. +other 34882650 hsa-mir-181a-1 Wounds and Injuries After analyzing competitive endogenous RNA network, 4 upregulated (MEG8, MEG3, MIR181A1HG, MIR4435-2HG) lncRNAs were found expressed during wound healing. +other 34882650 hsa-mir-4435-2 Wounds and Injuries After analyzing competitive endogenous RNA network, 4 upregulated (MEG8, MEG3, MIR181A1HG, MIR4435-2HG) lncRNAs were found expressed during wound healing. +circulation_biomarker_diagnosis_up 34882521 hsa-mir-132 Pancreatitis 3p was downregulated in AP patients' plasma and human pancreatic ductal HPDE6-C7 cells with caerulein induction. +lncRNA target 34882302 hsa-mir-21 Hyperoxia-Induced Lung Injury 5p and SKP2 mRNA, inhibiting the expression of SKP2, reducing the ubiquitination level of Nr2f2, increasing the expression of Nr2f2, promoting the binding of Nr2f2 and the C/EBPalpha promoter, upregulating C/EBPalpha mRNA level, and eventually alleviating HILI. +other 34882294 hsa-mir-27 Obesity RESULTS: We found no differences in the expression of PPAR-gamma and miR-27 in adipose tissue of obese patients vs. +other 34882294 hsa-mir-27a Obesity RESULTS: We found no differences in the expression of PPAR-gamma and miR-27 in adipose tissue of obese patients vs. +lncRNA target 34882114 hsa-mir-379 Angelman Syndrome Collectively, these results demonstrated that circ_0002984 promoted PDGF-bb-induced VSMC proliferation, migration, and invasion through the regulation of miR5p/FRS2 axis, suggesting a new insight into the pathogenesis of AS and the potential application of circ_0002984 in AS treatment. +genetics_knock down_suppress 34882112 hsa-mir-148b Angelman Syndrome In conclusion, circUSP9X knockdown relieved ox-LDL-triggered HUVEC injuries during AS progression partly by mediating the miR-148b-3p/KLF5 network. +other 34882040 hsa-mir-185 Virus Diseases Compared with normal transplanted patients, miR-29b, miR-185, and NR_073415.2 were significantly downregulated in the PBMC of post-transplant patients with viral infection. +other 34882040 hsa-mir-29b Virus Diseases Compared with normal transplanted patients, miR-29b, miR-185, and NR_073415.2 were significantly downregulated in the PBMC of post-transplant patients with viral infection. +lncRNA target 34881629 hsa-mir-203b Carcinoma, Hepatocellular The in vivo experiments upheld the LINC00536/miR-203b-5p/VEGFA axis in HCC. Conclusively, LINC00536 could promote HCC deterioration via tuning the miR-203b-5p/VEGFA axis. +genetics_knock down_promote 34881627 hsa-mir-592 Leukemia, Myeloid, Acute Moreover, miR-592 overexpression reversed the influences of LINC01116 overexpression on matrine-treated AML cells. +transcription factor target 34881229 hsa-mir-491 Prostatic Neoplasms, Castration-Resistant 5p@ZIF-8 not only significantly reduced C4-2 CRPC cell proliferation and migration but also significantly inhibited CRPC growth. +circulation_biomarker_diagnosis_up 34880957 hsa-mir-205 Myocardial Infarction 3p and TGF-beta1 were downregulated in plasma of MI patients in the TSN group. +exosome 34880915 hsa-mir-34a Melanoma Metformin Increases Sensitivity of Melanoma Cells to Cisplatin by Blocking Exosomal-Mediated miR-34a Secretion. +other 34880646 hsa-mir-429 Crohn Disease The constructed MIR3142HG/mir-429/PTGS2 ceRNA network may play a role in CD, and PTGS2 can be a potential immune-related biomarker in CD. +other 34880646 hsa-mir-142 Crohn Disease The constructed MIR3142HG/mir-429/PTGS2 ceRNA network may play a role in CD, and PTGS2 can be a potential immune-related biomarker in CD. +other 34880629 hsa-mir-21 gastric adenocarcinoma 5p/TLR4 regulatory axis in STAD. +circulation_biomarker_diagnosis_ns 34880446 hsa-mir-200b Hirschsprung Disease Three plasma miRNAs (miR-200a-3p, miR +circulation_biomarker_diagnosis_ns 34880446 hsa-mir-200a Hirschsprung Disease Three plasma miRNAs (miR-200a-3p, miR +circulation_biomarker_diagnosis_ns 34880446 hsa-mir-192 Hirschsprung Disease Three plasma miRNAs (miR-200a-3p, miR +genetics_knock down_promote 34880414 hsa-mir-200c Liver Injury Phenotypically, loss of miR-200c exacerbated cholestatic liver injury, including periductular fibrosis, intrahepatic inflammation, and biliary hyperplasia in both the BDL model and the 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) model. +transcription factor target 34880230 hsa-mir-675 facioscapulohumeral muscular dystrophy 1 upregulating small molecules inhibit DUX4 and DUX4-activated FSHD biomarkers in FSHD patient-derived myotubes. +transcription factor target 34879879 hsa-mir-425 Osteoporosis 5p might serve as a potential therapeutic target for the treatment of osteoporosis. +circulation_biomarker_diagnosis_ns 34879814 hsa-mir-27b Pre-Eclampsia CONCLUSION: miR-27b-3p expression in serum of pregnant women with PE was positively correlated with the severity of PE symptoms, suggesting the involvement of miR-27b-3p in PE occurrence. +epigenetics 34879371 hsa-mir-141 Pre-Eclampsia 3p and methylation status of the miR +transcription factor target 34879291 hsa-mir-17 Intervertebral Disc Degeneration In conclusion, H-sEVs miR5p alleviate IDD via promoting HNPCs matrix proliferation and synthesis, providing new therapeutic targets for IDD. +virus_miRNA 34878852 ebv-mir-BHRF1-3 Epstein-Barr Virus Infections Epstein-Barr Virus miR-BHRF1-3 Targets the BZLF1 3'UTR and Regulates the Lytic Cycle +genetics_GWAS 34878652 hsa-mir-2118 Infertility, Male The MIR2118 family has undergone tremendous expansion in the grass lineage, in which the miRNA targets numerous noncoding PHAS loci to produce 21-nt phased small interfering RNAs (phasiRNAs) involved in male fertility. +lncRNA target 34878161 hsa-mir-133b Squamous Cell Carcinoma of Head and Neck In conclusion, the current results indicated that HCG18 facilitated the progression of LHSCC by upregulating FGFR1 via miR133b. +other 34877935 hsa-mir-1262 Arthritis, Rheumatoid On the other hand, we also demonstrate that LINK-A could bind with microRNA 1262 as a sponge to control RA FLS aggression but not inflammation. +genetics_knock down_suppress 34877817 hsa-mir-138 Cystic Fibrosis Several in vitro strategies can partially correct DeltaF508-CFTR trafficking and function, including low-temperature, small molecules, overexpression of miR-138, or knockdown of SIN3A. +other 34877353 hsa-mir-146a Precursor Cell Lymphoblastic Leukemia-Lymphoma A total of 12 experimental groups included individual and combinational silenced ALL-associated miRNAs (hsa-miR-155, hsa-miR-146a, and hsa-miR-181a) and their combination with prednisolone. +other 34877353 hsa-mir-155 Precursor Cell Lymphoblastic Leukemia-Lymphoma A total of 12 experimental groups included individual and combinational silenced ALL-associated miRNAs (hsa-miR-155, hsa-miR-146a, and hsa-miR-181a) and their combination with prednisolone. +other 34877353 hsa-mir-181a Precursor Cell Lymphoblastic Leukemia-Lymphoma A total of 12 experimental groups included individual and combinational silenced ALL-associated miRNAs (hsa-miR-155, hsa-miR-146a, and hsa-miR-181a) and their combination with prednisolone. +transcription factor target 34876932 hsa-mir-29a Brain Injuries, Traumatic miR-29a-5p targets to NLRP3 through the binding on its 3'UTR and negatively regulates its expression in TBI model cells. +transcription factor target 34876915 hsa-mir-4461 Ovarian Neoplasms CONCLUSION: Alkannin restrains cell viability, metastasis, and EMT in OC by downregulating miR-4461 expression. +lncRNA target 34876904 hsa-mir-199a Carcinoma, Hepatocellular Besides, PTPRG-AS1 could promote HCC through miR-199a-3p/YWHAG axis. CONCLUSIONS: Taken together, we demonstrated PTPRG-AS1 may serve as a ceRNA and reversely regulates the expression of miR-199a-3p, thus facilitating HCC tumorigenesis and metastasis, which is expected to provide new clues for the treatment of HCC. +other 34876841 hsa-mir-198 Atrial Fibrillation Tregs or NK cells activated immune cells-related ceRNA subnetwork including 5 circRNAs (has_circ_0001190, has_circ_0006725, has_circ_0079284, has_circ_0005299, and has_circ_0002103), 4 miRNAs (has-miR-198, has-miR-623, has-miR-1246, and has-miR3p) and 4 DE hub genes was eventually constructed in AF. +other 34876841 hsa-mir-1246 Atrial Fibrillation Tregs or NK cells activated immune cells-related ceRNA subnetwork including 5 circRNAs (has_circ_0001190, has_circ_0006725, has_circ_0079284, has_circ_0005299, and has_circ_0002103), 4 miRNAs (has-miR-198, has-miR-623, has-miR-1246, and has-miR3p) and 4 DE hub genes was eventually constructed in AF. +other 34876841 hsa-mir-339 Atrial Fibrillation Tregs or NK cells activated immune cells-related ceRNA subnetwork including 5 circRNAs (has_circ_0001190, has_circ_0006725, has_circ_0079284, has_circ_0005299, and has_circ_0002103), 4 miRNAs (has-miR-198, has-miR-623, has-miR-1246, and has-miR3p) and 4 DE hub genes was eventually constructed in AF. +genetics_overexpression_promote 34876564 hsa-mir-135a Cardiomegaly Furthermore, forcing miR-135a overexpression exerted a significant protective effect against cardiac hypertrophy by inhibiting the activity of its downstream target TCF7, a critical member of Wnt signaling, and the protective effect could be reversed by AMO-135a. Altogether, our study demonstrated that lncRNAA02Rik upregulation could promote cardiac hypertrophy development via modulating miR-135a expression levels and TCF7 activity. +other 34876558 hsa-mir-181d Ovarian Neoplasms Oncogenic microRNA-181d binding to OGT contributes to resistance of ovarian cancer cells to cisplatin. +other 34876144 hsa-mir-24 Liver Neoplasms 5p/ROCK1. +genetics_overexpression_promote 34876142 hsa-mir-155 Cholangiocarcinoma 5p overexpressing cell lines decreased the phosphorylation level of RAF, MEK and ERK, as well as the proliferation of CCA cells. +circulation_biomarker_diagnosis_ns 34876134 hsa-mir-149 Implantation Failure 3p had consistent direction changes in blood samples of patients with RIF. +circulation_biomarker_diagnosis_ns 34876134 hsa-mir-150 Implantation Failure 3p had consistent direction changes in blood samples of patients with RIF. +circulation_biomarker_diagnosis_ns 34876134 hsa-mir-342 Implantation Failure 3p had consistent direction changes in blood samples of patients with RIF. +circulation_biomarker_diagnosis_ns 34876134 hsa-mir-146b Implantation Failure 3p had consistent direction changes in blood samples of patients with RIF. +circRNA target 34876132 hsa-mir-339 Osteosarcoma CONCLUSIONS: CircDOCK1 can promote progression and regulate cisplatin sensitivity in OS via the miR +genetics_knock down_promote 34875555 hsa-mir-665 Lymphoma, Large B-Cell, Diffuse Knockdown of miR-665 promoted DLBCL cell proliferation and invasion and decreased cell apoptosis, whereas miR-665 overexpression showed opposite effects on DLBCL cell malignant behaviors. +genetics_knock down_promote 34875555 hsa-mir-665 Lymphoma, B-Cell Knockdown of miR-665 promoted DLBCL cell proliferation and invasion and decreased cell apoptosis, whereas miR-665 overexpression showed opposite effects on DLBCL cell malignant behaviors. +lncRNA target 34875451 hsa-mir-142 Cholesteatoma, Middle Ear 5p in the regulation of the inflammatory response in AMEC through its inhibitory effect on CDK5 expression, we studied the inflammatory response in HaCaT cells transfected with small interfering RNA against CDK5 (si-CDK5) and a miR +other 34875312 hsa-mir-21 Carcinoma, Hepatocellular In addition, circRNA-001241 facilitated HCC sorafenib-resistance by regulating the miR5p/TIMP3 axis. +lncRNA target 34875217 hsa-mir-125b Macular Degeneration In conclusion, this study illustrated that miR-125b can protect RPE from oxidative damage via targeting Nrf2/HIF-1alpha signal pathway and potentially may serve as a therapeutic agent of AMD. +genetics_overexpression_promote 34874810 hsa-mir-506 Carcinoma, Non-Small-Cell Lung Our results revealed that miR-506 is high expression in NSCLC cell lines, and the overexpression of miR-506 could inhibit cell viability and enhance cell apoptosis in H1299 and A549 cells. +lncRNA target 34874752 hsa-mir-196b Mesothelioma Conclusions: We suggest that geldanamycin has potential for the treatment of mesothelioma via regulating miR-196b-5p. +exosome 34874565 hsa-mir-379 Lymphoma, Large B-Cell, Diffuse Four exosomal miRNAs (miR5p, miR-135a-3p, miR-4476, and miR-451a) were differentially expressed between patients with DLBCL and CCs, with an AUC of 0.78. +exosome 34874565 hsa-mir-451a Lymphoma, Large B-Cell, Diffuse Four exosomal miRNAs (miR +exosome 34874565 hsa-mir-135a Lymphoma, Large B-Cell, Diffuse Four exosomal miRNAs (miR5p, miR-135a-3p, miR-4476, and miR-451a) were differentially expressed between patients with DLBCL and CCs, with an AUC of 0.78. +genetics_knock down_suppress 34874325 hsa-let-7c Brain Ischemia Knockdown of circ_HECTD1 protected against cerebral ischemia injury in OGD/R-treated PC-12 cells depending on the regulation of let-7c-5p/ROCK1 axis. +genetics_overexpression_promote 34874324 hsa-mir-1 Brain Injuries, Traumatic Downregulation of miR-31 promoted traumatic neuron injury-induced neuronal cell injury, and its overexpression did the opposite. +genetics_knock down_suppress 34874224 hsa-mir-23a Stomach Neoplasms In vivo, elevated miR-23a-3p restrained the volume and tumor of GC and reduced the expression of CCL22 and phosphorylated PIK3/Akt, while knockdown miR-23a-3p motivated tumor growth. +genetics_knock down_promote 34873899 hsa-mir-1270 Osteosarcoma Taken together, knockdown of miR-1270 may inhibit the development of OS via targeting CGN. +other 34873501 hsa-mir-181d Meningioma Conclusions MiR-181d has potential as a biomarker for meningiomas and is associated with the tumor progression of meningiomas. +circulation_biomarker_diagnosis_up 34873439 hsa-mir-539 Cerebrovascular Occlusive Diseases The results of this study suggested that circulating miR-539 in peripheral blood may be a potential marker for predicting blood-brain barrier permeability after ischemic stroke. +transcription factor target 34873433 hsa-mir-133b Diabetes Mellitus Hence, miR-133b inhibition may be a useful strategy for treating diabetic wounds. +circulation_biomarker_diagnosis_up 34873417 hsa-mir-21 Coronary Disease Our results indicated that miR-21, CX43, and the level of inflammatory cytokines including ICAM-1 and IL-1beta were upregulated, while SPRY1 was downregulated in blood samples from CHD patients compared with the controls. +circulation_biomarker_diagnosis_up 34873417 hsa-mir-21 Depression Our results indicated that miR-21, CX43, and the level of inflammatory cytokines including ICAM-1 and IL-1beta were upregulated, while SPRY1 was downregulated in blood samples from CHD patients compared with the controls. +genetics_overexpression_promote 34873301 hsa-mir-181a Leukemia, Large Granular Lymphocytic miRNA sequencing in T-LGL leukemia cases and aged-matched healthy control TEMRA cells revealed overexpression of miR-181a. By using TL1, a human T-LGL cell line, we could show that miR-181a is an actor in T-LGL leukemia, driving STAT3 activation by SOCS3 inhibition and ERK1/2 phosphorylation by DUSP6 inhibition and verified this mechanism in an independent cell line. +lncRNA target 34873163 hsa-mir-512 Breast Neoplasms 5p from the 3'-UTR of STAT1, circRPPH1 inhibited the suppressive role of miR +lncRNA target 34872582 hsa-mir-885 Adenocarcinoma of Lung Wnt10b as a target of miR +other 34872454 hsa-mir-627 Colonic Neoplasms Beyond that, downregulated expression of IFNG-AS1 may repress malignant progression of colon adenocarcinoma by regulating miR3p. +circulation_biomarker_diagnosis_ns 34872453 hsa-mir-410 Pulmonary Disease, Chronic Obstructive This investigation aimed to assess the levels of serum OIP5-AS1 and micro RNA +lncRNA target 34872452 hsa-mir-25 Intervertebral Disc Degeneration 3p as a novel regulatory axis for the molecular targets of IDD therapy. +genetics_overexpression_promote 34872451 hsa-mir-340 Insulin Resistance Furthermore, overexpression of miR +lncRNA target 34872448 hsa-mir-520d Melanoma In conclusion, we have found out that miR-520d-3p suppressed melanoma tumorigenesis by inhibiting ASF1B, which could be a promising target for melanoma therapy. +other 34872436 hsa-mir-504 Ischemia In addition, microRNA-seq helped us determine that Mir504-5p was differentially expressed in ischemic flaps. +lncRNA target 34871862 hsa-mir-197 Fibrosarcoma However, there is hardly any evidence on the involvement of tumor-suppressive miR-197 reported in our previous study in augmenting the sensitivity of fibrosarcoma cells to Dox. +transcription factor target 34871825 hsa-mir-10b Bronchial Diseases By referring to other previous studies, we concluded that miR-10b-5p might be a potent target in the treatment of airway diseases. +genetics_overexpression_suppress 34870753 hsa-mir-1246 Thyroid Neoplasms Analysis of GEO data demonstrated significant miR-1246 downregulation in thyroid cancer, and we confirmed that overexpression of miR-1246 can inhibit migratory, invasive, and proliferative activity in vitro and tumor growth in vivo. +genetics_overexpression_promote 34870560 hsa-mir-144 Neonatal Sepsis Overexpression of CASC15 may promote the inflammatory response of NS by targeted regulating the expression of miR +lncRNA target 34870557 hsa-mir-185 Colorectal Neoplasms TEAD1 (TEA domain transcription factor1) - a major effector of the Hippo signaling was proved to serve as the target of miR +lncRNA target 34870494 hsa-mir-492 Carcinoma, Renal Cell We further explored the VEGFA-associated kinase (ATM in KICH as well as CDK1 and AURKB in KIRP) and VEGFA-associated microRNA (miRNA) targets (MIR-21 in KICH as well as MIR-213, MIR-383, and MIR-492 in KIRP). +lncRNA target 34870494 hsa-mir-213 Carcinoma, Renal Cell We further explored the VEGFA-associated kinase (ATM in KICH as well as CDK1 and AURKB in KIRP) and VEGFA-associated microRNA (miRNA) targets (MIR-21 in KICH as well as MIR-213, MIR-383, and MIR-492 in KIRP). +lncRNA target 34870494 hsa-mir-21 Carcinoma, Renal Cell We further explored the VEGFA-associated kinase (ATM in KICH as well as CDK1 and AURKB in KIRP) and VEGFA-associated microRNA (miRNA) targets (MIR-21 in KICH as well as MIR-213, MIR-383, and MIR-492 in KIRP). +lncRNA target 34870494 hsa-mir-383 Carcinoma, Renal Cell We further explored the VEGFA-associated kinase (ATM in KICH as well as CDK1 and AURKB in KIRP) and VEGFA-associated microRNA (miRNA) targets (MIR-21 in KICH as well as MIR-213, MIR-383, and MIR-492 in KIRP). +exosome 34870106 hsa-mir-28 Alzheimer Disease METHODS: Exosomes were first isolated from CSF samples of 48 subjects (8 controls, 28 AD, and 12 FTD), followed by RNA extraction and quantitative PCR to measure the expression of miR-320a, miR +target gene 34869970 hsa-mir-199 Pancreatic Neoplasms MiR-199 Reverses the Resistance to Gemcitabine in Pancreatic Cancer by Suppressing Stemness through Regulating the Epithelial-Mesenchymal Transition. +other 34869733 hsa-mir-483 Cushing Syndrome 3p) were differentially expressed compared to healthy dogs. +other 34869733 hsa-mir-222 Cushing Syndrome 3p) were differentially expressed compared to healthy dogs. +other 34869733 hsa-mir-126 Cushing Syndrome 3p) were differentially expressed compared to healthy dogs. +other 34869733 hsa-mir-141 Cushing Syndrome Additionally, miR3p was expressed significantly lower (p = 0.009) in dogs with csACTs that had a histopathological Utrecht score of >/= 11 compared to those with a score of <11. +other 34869733 hsa-mir-375 Cushing Syndrome 3p) were differentially expressed compared to healthy dogs. +other 34869721 hsa-mir-29 Pasteurella Multocida Infections Characterization of microRNA Profiles in Pasteurella multocida-Infected Rabbits and Identification of miR5p as a Regulator of Antibacterial Immune Response. +genetics_GWAS 34869683 hsa-mir-21 Obesity Results achieved confirmed the role of epigenetics in the obesity-related cardiovascular complications and firstly supported the potential role of plasma miRNA-21 and IL-6 and NF-kB DNA methylation changes in nucleated blood cells as potential biomarkers for predicting cardiovascular risk in obesity. +other 34869393 hsa-mir-378a Carcinoma, Hepatocellular CircCRIM1 Promotes Hepatocellular Carcinoma Proliferation and Angiogenesis by Sponging miR-378a-3p and Regulating SKP2 Expression. +lncRNA target 34869346 hsa-mir-92a Uterine Cervical Neoplasms miR-92a-3p promoted the malignant behavior of CC stem cells by targeting LATS1, which regulated TAZ and E-cadherin. +lncRNA target 34869311 hsa-mir-667 Osteoarthritis Taken together, our findings demonstrate that circPan3 promotes ghrelin synthesis and chondrocyte autophagy via targeting miR +lncRNA target 34869303 hsa-mir-24 Fibrosis, Renal Findings concur in showing that lncRNA 74.1 could induce cellular autophagy and alleviate renal fibrosis by regulating the miR +other 34869091 hsa-mir-4731 Congenital Pulmonary Airway Malformations 3p to SLAIN motif family member 1. +other 34869091 hsa-mir-454 Congenital Pulmonary Airway Malformations 3p to SLAIN motif family member 1. +other 34869091 hsa-mir-32 Congenital Pulmonary Airway Malformations 3p to SLAIN motif family member 1. +circRNA target 34869035 hsa-mir-545 Glioma Finally, an in vivo experiment was conducted, which demonstrated that circ_0001367 inhibited glioma growth in vivo by modulating miR +exosome 34868916 hsa-mir-185 Squamous Cell Carcinoma of Head and Neck To conclude, the findings demonstrate exosomal miR +lncRNA target 34868902 hsa-mir-489 Pancreatic Carcinoma 3p inhibited the growth of pancreatic cancer. +other 34868829 hsa-mir-7 Lyme Disease The miR-7 level was upregulated in PDL tissues and reduced in differential PDLCs. +genetics_knock down_suppress 34868829 hsa-mir-7 Periodontitis Conclusions Knockdown of ANRIL inhibited osteogenic differentiation via sponging miR-7 through the NF-B pathway, suggesting that ANRIL might be a therapeutic target for periodontitis. +genetics_knock down_promote 34868669 hsa-mir-485 Glioma Besides, circ_0082375 knockdown hampered the growth of glioma growth by regulating the miR +transcription factor target 34868398 hsa-mir-190 Myocardial Reperfusion Injury 5p can reduce the inflammation and apoptosis of myocardium by targeting PHLPP1, thereby alleviating MIRI. +other 34868364 hsa-mir-20b Breast Neoplasms RBM38 is negatively regulated by miR-320b and enhances Adriamycin resistance in breast cancer cells. +other 34868361 hsa-mir-21 Leukemia, Myeloid, Acute Long non-coding RNA MIR17HG sponges microRNA-21 to upregulate PTEN and regulate homoharringtonine-based chemoresistance of acute myeloid leukemia cells. +circulation_biomarker_diagnosis_ns 34868358 hsa-mir-103a Colorectal Neoplasms The aim of the present study was to evaluate a panel of seven circulating miRNAs (miR-106a-5p, miR +circulation_biomarker_diagnosis_ns 34868358 hsa-mir-16 Colorectal Neoplasms The aim of the present study was to evaluate a panel of seven circulating miRNAs (miR-106a-5p, miR +circulation_biomarker_diagnosis_ns 34868358 hsa-mir-191 Colorectal Neoplasms The aim of the present study was to evaluate a panel of seven circulating miRNAs (miR-106a-5p, miR +circulation_biomarker_diagnosis_ns 34868358 hsa-mir-210 Colorectal Neoplasms The aim of the present study was to evaluate a panel of seven circulating miRNAs (miR-106a-5p, miR +circulation_biomarker_diagnosis_ns 34868358 hsa-mir-106a Colorectal Neoplasms The aim of the present study was to evaluate a panel of seven circulating miRNAs (miR-106a-5p, miR +circulation_biomarker_diagnosis_ns 34868358 hsa-mir-21 Colorectal Neoplasms The aim of the present study was to evaluate a panel of seven circulating miRNAs (miR-106a-5p, miR +circulation_biomarker_diagnosis_ns 34868358 hsa-mir-155 Colorectal Neoplasms The aim of the present study was to evaluate a panel of seven circulating miRNAs (miR-106a-5p, miR +other 34868237 hsa-mir-150 Carcinoma, Non-Small-Cell Lung The two lncRNAs ABTB1 and NPTN with the hsa-miR5p and mRNA SERPINE1 were significantly associated with resistance to EGFR-TKIs and survival in NSCLC. +circulation_biomarker_diagnosis_ns 34868211 hsa-mir-224 Cysts These data show that peripheral blood monocyte miR +circulation_biomarker_diagnosis_ns 34868211 hsa-mir-545 Cysts These data show that peripheral blood monocyte miR +circulation_biomarker_diagnosis_ns 34868079 hsa-mir-25 Arthritis, Rheumatoid 3p and serum levels of sTWEAK may have use in the early clinical diagnosis of RA. +circulation_biomarker_diagnosis_ns 34868079 hsa-mir-451a Arthritis, Rheumatoid 3p and serum levels of sTWEAK may have use in the early clinical diagnosis of RA. +circulation_biomarker_diagnosis_up 34867700 hsa-mir-519a Glioblastoma In GB cells, circNUP98 was localized to both the nucleus and cytoplasm and it interacted with pre-mature miR-519a-3p. +genetics_overexpression_promote 34867446 hsa-mir-183 Liver Cirrhosis Next, we used lentivirus to overexpress FOXO1 in LX-2 cells, and we found that overexpression of FOXO1 reversed the promotion of miR +other 34867172 hsa-mir-155 Epilepsy, Temporal Lobe 5p, hsa-miR-200c-3p, etc.), and 3 DEmRNAs (SCN2A, DYRK2, and MAPK8), which belonging to apoptotic and epileptic terms. +other 34867172 hsa-mir-200c Tuberous Sclerosis 5p, hsa-miR-200c-3p, etc.), and 3 DEmRNAs (SCN2A, DYRK2, and MAPK8), which belonging to apoptotic and epileptic terms. +other 34867172 hsa-mir-155 Tuberous Sclerosis 5p, hsa-miR-200c-3p, etc.), and 3 DEmRNAs (SCN2A, DYRK2, and MAPK8), which belonging to apoptotic and epileptic terms. +other 34867172 hsa-mir-200c Epilepsy, Temporal Lobe 5p, hsa-miR-200c-3p, etc.), and 3 DEmRNAs (SCN2A, DYRK2, and MAPK8), which belonging to apoptotic and epileptic terms. +other 34867172 hsa-mir-195 Epilepsy, Temporal Lobe 5p, hsa-miR-200c-3p, etc.), and 3 DEmRNAs (SCN2A, DYRK2, and MAPK8), which belonging to apoptotic and epileptic terms. +other 34867172 hsa-mir-195 Tuberous Sclerosis 5p, hsa-miR-200c-3p, etc.), and 3 DEmRNAs (SCN2A, DYRK2, and MAPK8), which belonging to apoptotic and epileptic terms. +exosome 34866540 hsa-mir-653 Thyroid Cancer, Papillary These results evidenced that exosomal circ007293 induced EMT and augmented the invasive and migratory abilities of PTC cells via the miR5p/PAX6 axis, suggesting that it may serve as a promising biomarker for cancer progression. +lncRNA target 34866525 hsa-mir-299 Breast Neoplasms In conclusion, above findings conclude that lncRNA DLGAP1-AS1 promotes BC ADR-resistance through WTAP/DLGAP1-AS1/miR3p feedback loop. +other 34866368 hsa-mir-517a Pre-Eclampsia Further studies are required to investigate a possible role for Hsa-miR-517a/b in the pathogenesis of PE. +circRNA target 34866220 hsa-mir-1253 Prostatic Neoplasms Simultaneously, miR-1253 hindered PCa cell progression via regulating NRBP1. +lncRNA target 34865451 hsa-mir-24 Diabetic Retinopathy Furthermore, it may be a new research direction of PDR to validate the target mRNAs of hsa-miR +lncRNA target 34865451 hsa-mir-197 Diabetic Retinopathy Furthermore, it may be a new research direction of PDR to validate the target mRNAs of hsa-miR +lncRNA target 34865205 hsa-mir-651 Breast Neoplasms The aim of this study was to elucidate the role of hsa-miR-3651 for predicting of local control (LC) in early breast cancer. CONCLUSION: The current study revealed that hsa-miR-3651 is a predictor of LC in early breast cancer via its putative target protein FRMD3. +transcription factor target 34865098 hsa-mir-155 Alzheimer Disease 5p as a target for AD treatment. +exosome 34864822 hsa-mir-361 Prostatic Neoplasms This sheds a new insight into the regulation of PCa distant metastasis by exosomal HOXD-AS1 mediated miR5p/FOXM1 axis, and provided a promising liquid biopsy biomarker to guide the detection and treatment of metastatic PCa. +genetics_overexpression_promote 34864645 hsa-mir-199a Cardiotoxicity The cardiac-specific overexpression of miR-199a-3p promoted cell cycle re-entry and cell proliferation, resulting in relief from cardiac senescence. The elevation of miR-199a-3p might provide a dual therapeutic advantage in Dox cardiotoxicity therapy by simultaneously preventing cardiac senescence and reducing the spread of senescence. +lncRNA target 34863990 hsa-mir-185 Leukemia, Myeloid, Acute 5p inhibited AML progression and downregulated AML cells' proliferation and invasion. +other 34863964 hsa-mir-145 Myocardial Infarction RESULTS: AIFM1 expression was markedly highly elevated, while miR5p expression was significantly down-regulated in the myocardial infarction animal model and H9c2 cells under hypoxia. +other 34863964 hsa-mir-145 Myocardial Ischemia CONCLUSION: AIFM1 may exacerbate myocardial ischemic injury by promoting inflammation and the injury of cardiomyocytes, and its up-regulation may be partly due to the down-regulation of miR5p. +lncRNA target 34863307 hsa-mir-221 Asthma 5p induced the protein expression of FOXP3, and suppressed that of SOCS1 and RORgammat in in vitro model of asthma. +genetics_overexpression_promote 34863279 hsa-mir-614 Carcinoma, Hepatocellular In rescue assays, we confirmed that overexpression of YY1 or miR +genetics_overexpression_suppress 34863188 hsa-mir-214 Prostatic Neoplasms RESULTS: Overexpression of miRNA +target gene 34863180 hsa-mir-130a Carcinoma, Non-Small-Cell Lung Silencing of the lncRNA H19 enhances sensitivity to X-ray and carbon-ions through the miR-130a-3p /WNK3 signaling axis in NSCLC cells. +lncRNA target 34863152 hsa-mir-545 Nasopharyngeal Carcinoma All inhibiting functions generated by CRNDE down-regulation upon NPC progression could be counterbalanced or synergistically exacerbated, depending on miR +lncRNA target 34863149 hsa-mir-193b Triple Negative Breast Neoplasms We further demonstrate that our top candidate, miR-193b, regulates these phenotypes to an extent stronger than individual pathway inhibition, thus emphasizing that its effect on TNBC aggressiveness is mediated by the coordinated repression of these functionally interconnected pathways. +other 34862716 hsa-mir-222 Retinoblastoma Luciferase reporter assays were performed to explore the binding between miR5p and retinoblastoma susceptibility protein (RB1) gene in VSMCs. +other 34861864 hsa-mir-653 Prostatic Neoplasms CONCLUSIONS: Our study suggested that circSERPINA3 regulated apoptosis, autophagy and aerobic glycolysis of PCa cells by competitively binding to miR5p and recruiting BUD13. +genetics_overexpression_promote 34861847 hsa-mir-93 Urinary Bladder Neoplasms 5p overexpression may contribute to BC progression via suppressing BTG2 expression. +genetics_overexpression_promote 34861846 hsa-mir-340 Urinary Bladder Neoplasms Functionally, overexpression of miR-340 suppressed the proliferation and induced apoptosis in BC cells, while Glut-1 reversed the suppression of proliferation or induction of apoptosis induced by miR-340. +genetics_knock down_promote 34861803 hsa-mir-873 Carcinoma, Non-Small-Cell Lung Circ_SETD3 knockdown improved gefitinib sensitivity and repressed NSCLC cell malignancy via miR +circRNA target 34861798 hsa-mir-582 Tuberculosis In conclusion, our results demonstrated that hsa_circ_0045474 down-regulation induced macrophage autophagy in tuberculosis via miR5p/ TNKS2 axis, implying a novel strategy to treat the occurrence of active pulmonary tuberculosis caused by immune escape of M. +transcription factor target 34861581 hsa-mir-4317 Carcinoma, Hepatocellular Overall, our data suggest that miR-4317 is a novel tumor suppressor to suppress HCC progression through PI3K/AKT pathway by targeting ZNF436, and may serve as a prognostic biomarker and therapeutic target for HCC. +circulation_biomarker_diagnosis_ns 34861526 hsa-let-7a Breast Neoplasms Our biosensors were further tested using human serum spiked with the let-7a and the extracts of the breast adenocarcinoma cells spiked with and without the let-7a, respectively. +circulation_biomarker_diagnosis_ns 34861059 hsa-mir-34a Coronary Disease Hence, this study aimed to assess the correlation of miR-34a with disease risk, blood lipid, coronary artery stenosis, inflammatory cytokines, and cell adhesion molecules of CHD. +lncRNA target 34860809 hsa-mir-34a Pancreatic Carcinoma OBJECTIVES: This study aimed to enhance the sensitivity of pancreatic ductal adenocarcinoma cells by microRNA-34a (miR-34a)-mediated targeting of Notch 1. CONCLUSIONS: MicroRNA-34a sensitized pancreatic cancer cells to gemcitabine treatment by inhibiting Notch 1 signaling in pancreatic cancer stem cells, indicating that miR-34a has the potential to be developed as a novel therapeutic agent for the treatment of gemcitabine-resistant pancreatic ductal adenocarcinoma cells. +lncRNA target 34860160 hsa-mir-15a Stomach Neoplasms Moreover, the data suggested that SGK1 reversed the suppression effect of miR-15a-5p on gastric cancer cell migration (P < .01). Moreover, SGK1 may exert an inhibitory effect in gastric cancer by being targeted by miR-15a-5p. +lncRNA target 34860147 hsa-mir-145 Colonic Neoplasms 5p, and their expression in CC could be suppressed by miR +genetics_overexpression_promote 34859848 hsa-mir-3174 Endometrial Neoplasms Overexpression of miR-3174 partially abolished the role of LINC00958 in accelerating the malignant phenotypes of EC cells. +genetics_overexpression_suppress 34859847 hsa-mir-4282 Carcinoma, Ovarian Epithelial EOC patients expressing low level of miR-4282 had higher incidences of lymphatic metastasis and distant metastasis, as well as worse prognosis than those overexpressing miR-4282. +genetics_knock down_promote 34859846 hsa-mir-153 Prostatic Neoplasms In PCa, high miRNA-153 expression and loss of PTEN expression were associated significantly with higher Gleason patterns, higher Gleason scores, and higher Grade groups. +lncRNA target 34859735 hsa-mir-1343 Carcinoma, Hepatocellular In conclusion, ASMTL-AS1 acts as a carcinogen in HCC through competing endogenous RNA (ceRNA) activity in the miR +other 34859371 hsa-mir-148a Breast Neoplasms RESULTS: Upregulation of PVT1 and ROCK1, and downregulation of miR-148a-3p were observed in BC tissues and cell lines. CONCLUSION: These data demonstrated that PVT1 was upregulated and facilitated to the cell migration and invasion of BC by the regulation of miR-148a-3p and ROCK1, indicating that PVT1 may be a potential biomarker of BC diagnosis and treatment. +tissue_expression_up 34859319 hsa-mir-140 Osteoarthritis Lnxc-CL/miR-140 was evaluated for its ability to regulate gene expression in chondrocytes in vitro and to provide in vivo therapeutic effects for knee osteoarthritis in rats. +genetics_knock down_promote 34859256 hsa-mir-44352 Liver Neoplasms Knockdown of MIR44352HG significantly inhibited the proliferation, migration and invasion of liver cancer cells. +other 34858863 hsa-mir-148a Uterine Cervical Neoplasms HK2 Is a Crucial Downstream Regulator of miR-148a for the Maintenance of Sphere-Forming Property and Cisplatin Resistance in Cervical Cancer Cells. +genetics_knock down_promote 34858853 hsa-mir-338 Astrocytoma Knockdown or deactivation of DNMT1 decreased the methylation rate of the miR +other 34858831 hsa-mir-760 Carcinoma, Non-Small-Cell Lung mediated PI3K/AKT and MEK/ERK pathways. +other 34858518 hsa-mir-138 Osteosarcoma OBJECTIVE: To explore the effect of miR-138 on the function of follicular helper T (Tfh) cells and the differentiation of B cells in osteosarcoma. CONCLUSION: Downregulating the expression of miR-138 in osteosarcoma can improve the dysfunction of CD4(+)CXCR5(+)Tfh cells and promote the differentiation of B cells. +other 34858418 hsa-mir-212 Intervertebral Disc Degeneration The PKD1-miR-20b-5p-AP000797 and CCNB1-miR3p-AC079834 axes may regulate IDD. +other 34858418 hsa-mir-20b Intervertebral Disc Degeneration The PKD1-miR-20b-5p-AP000797 and CCNB1-miR3p-AC079834 axes may regulate IDD. +lncRNA target 34858053 hsa-mir-21 Adenocarcinoma of Lung 5p target genes, then analyzed their expression patterns as well as prognostic value in LUAD. +circulation_biomarker_diagnosis_up 34858034 hsa-mir-192 Acquired Immunodeficiency Syndrome 5p and miR-1246 in serum exosomes might be a potential biomarker for AIDS combined with TM infection patients, which may be involved in TGF-beta signaling pathway, AMPK signaling pathway, Wnt signaling pathway, MAPK signaling pathway, cGMP-PKG and cAMP signaling pathway, etc. +circulation_biomarker_diagnosis_up 34858034 hsa-mir-1246 Acquired Immunodeficiency Syndrome 5p and miR-1246 in serum exosomes might be a potential biomarker for AIDS combined with TM infection patients, which may be involved in TGF-beta signaling pathway, AMPK signaling pathway, Wnt signaling pathway, MAPK signaling pathway, cGMP-PKG and cAMP signaling pathway, etc. +circulation_biomarker_diagnosis_up 34858034 hsa-mir-194 Acquired Immunodeficiency Syndrome 5p and miR-1246 in serum exosomes might be a potential biomarker for AIDS combined with TM infection patients, which may be involved in TGF-beta signaling pathway, AMPK signaling pathway, Wnt signaling pathway, MAPK signaling pathway, cGMP-PKG and cAMP signaling pathway, etc. +circulation_biomarker_diagnosis_up 34858034 hsa-mir-1246 talaromycosis 5p and miR-1246 in serum exosomes might be a potential biomarker for AIDS combined with TM infection patients, which may be involved in TGF-beta signaling pathway, AMPK signaling pathway, Wnt signaling pathway, MAPK signaling pathway, cGMP-PKG and cAMP signaling pathway, etc. +circulation_biomarker_diagnosis_up 34858034 hsa-mir-194 talaromycosis 5p and miR-1246 in serum exosomes might be a potential biomarker for AIDS combined with TM infection patients, which may be involved in TGF-beta signaling pathway, AMPK signaling pathway, Wnt signaling pathway, MAPK signaling pathway, cGMP-PKG and cAMP signaling pathway, etc. +circulation_biomarker_diagnosis_up 34858034 hsa-mir-192 talaromycosis 5p and miR-1246 in serum exosomes might be a potential biomarker for AIDS combined with TM infection patients, which may be involved in TGF-beta signaling pathway, AMPK signaling pathway, Wnt signaling pathway, MAPK signaling pathway, cGMP-PKG and cAMP signaling pathway, etc. +other 34857901 hsa-mir-223 Atherosclerosis HSPA7 is differentially increased in human atheroma and promotes the inflammatory transition of vascular smooth muscle cells by sponging miR-223. +circulation_biomarker_diagnosis_ns 34857759 hsa-mir-375 Tuberculosis, Gastrointestinal 3p, the pulmonary TB specific marker was found in higher amount in the plasma of ITB patients than CD while reverse expression was observed in the ileocaecal/terminal ileal tissues of the same patients. +circulation_biomarker_diagnosis_ns 34857759 hsa-mir-375 Crohn Disease 3p, the pulmonary TB specific marker was found in higher amount in the plasma of ITB patients than CD while reverse expression was observed in the ileocaecal/terminal ileal tissues of the same patients. +lncRNA target 34857398 hsa-mir-383 Uterine Cervical Neoplasms CONCLUSIONS: CASC9-1 exerted influences on various biological behaviors of cervical SCC cells via targeting miR +other 34857317 hsa-mir-21 Lung Neoplasms This work describes the unique design of a bidirectional activatable synergetic DNA machine (BAS-DNA machine) for speeded and ultrasensitive determination of microRNA-21 (miR-21), a well-known biomarker for biomedical research and early diagnosis of lung cancer. +genetics_overexpression_promote 34857012 hsa-mir-154 Osteosarcoma CONCLUSIONS: Circ-ATAD1 is overexpressed in OS and suppresses miR +genetics_overexpression_promote 34857003 hsa-mir-613 Pigmented Paravenous Chorioretinal Atrophy miR-206 and miR-613 suppressed HnRNPK expression by targeting its 3'-UTR in PrCa cell lines in which HnRNPK is overexpressed. To explore the potential biological function, proliferation and colony formation of PrCa cells in vitro and tumor growth in vivo were also dramatically suppressed upon reintroduction of miR-206/miR-613. +genetics_overexpression_promote 34857003 hsa-mir-206 Pigmented Paravenous Chorioretinal Atrophy miR-206 and miR-613 suppressed HnRNPK expression by targeting its 3'-UTR in PrCa cell lines in which HnRNPK is overexpressed. To explore the potential biological function, proliferation and colony formation of PrCa cells in vitro and tumor growth in vivo were also dramatically suppressed upon reintroduction of miR-206/miR-613. +circulation_biomarker_diagnosis_up 34856993 hsa-mir-485 Carcinoma, Non-Small-Cell Lung 5p is downregulated in both cancerous cell lines and peripheral blood serum isolated from NSCLC patients compared to reciprocal control groups. +exosome 34856955 hsa-mir-107 Stomach Neoplasms CONCLUSIONS: These findings demonstrated that exosome-transmitted miR-107 significantly enhanced the sensitivity of resistant gastric cancer cells to chemotherapeutic agents by mediating the HMGA2/mTOR/P-gp axis and exosomal miR-107 may be a novel target in gastric cancers treatment. +other 34856948 hsa-mir-6838 Stomach Neoplasms CONCLUSIONS: Hsa_circ_0008434 may promote GC proliferation, invasion and migration by regulating the expression of miR-6838 and USP9X. +other 34856848 hsa-mir-214 Carcinoma, Non-Small-Cell Lung Overall, TDRG1 exerts carcinogenic effects in NSCLC by regulating the miR5p/KLF5 axis. +other 34856073 hsa-mir-34a Breast Neoplasms Kaplan-Meier plotter analysis found that resveratrol-induced expression changes in key RNAs, such as E2F2, JUN, FOS, BRCA1, CDK1, CDKN1A, TNF, and hsa-miR-34a-5p, significantly improved the prognosis of breast cancer patients, which was further verified using real-time quantitative PCR (qPCR) and western blotting. +other 34856019 hsa-mir-210 Corneal Injuries In addition, miR-210 is decreased after corneal injury while EphA2 is increased. +lncRNA target 34855515 hsa-mir-203a Acute Lung Injury Bioinformatics analysis, ELISA assay, quantitative reverse transcription polymerase chain reaction analysis, biotinylated RNA pull-down assay, apoptosis test, and Western blot analysis demonstrated that the LINC01194 could act as a microRNA (miR) miR-203a-3p sponge to activate the inflammatory response in LPS-induced ALI model through post-transcriptional upregulation of macrophage inflammatory protein (MIP-2). +genetics_overexpression_promote 34855100 hsa-mir-4731 Choriocarcinoma 5p elevation or HIF3A suppression reversed the promoting effect of OGFRP1 overexpression on the malignant behaviors of ropivacaine-treated choriocarcinoma cells. +circulation_biomarker_diagnosis_up 34855075 hsa-mir-155 Graves Disease Though there is a trend of elevation of miR- 155 in THD than in simple hyperthyroidism patients, we did not find statistically significant differences in the expression of these miRNAs in the blood of THD patients, but we found that miR-155 was significantly up-regulated in patients with Graves' disease with or without THD in comparison with healthy controls. Thus, miR-155 can serve as a novel biomarker for Graves' disease and can play important roles in pathogenesis of Graves' disease. +lncRNA target 34854520 hsa-mir-339 Cardiomegaly Valosin-containing protein (VCP), a suppressor of cardiac hypertrophy via inhibiting mechanistic target of rapamycin (mTOR) signaling, was validated as a target of miR +lncRNA target 34854396 hsa-mir-125a Arthritis, Rheumatoid CONCLUSIONS: This study suggests that miR-125a-3p could inactivate the Wnt/beta-catenin and NF-kappaB pathways to reduce the proliferation and inflammation response of RA-FLS via targeting MAST3. +lncRNA target 34854395 hsa-mir-1207 Spinal Cord Injuries Moreover, RP11-253E3.3-hsa-miR5p-FOXO3 axis may be a promising therapeutic target for skeletal muscle atrophy after SCI. +lncRNA target 34854395 hsa-mir-1207 Muscular Atrophy Moreover, RP11-253E3.3-hsa-miR5p-FOXO3 axis may be a promising therapeutic target for skeletal muscle atrophy after SCI. +other 34854361 hsa-mir-16 Polycystic Ovary Syndrome Our study revealed miR-16 regulates Apelin13 to mediate the PI3K/Akt signalling pathway and, thereby mediates PCOS progression. +circulation_biomarker_diagnosis_down 34854318 hsa-mir-381 Colorectal Neoplasms 3p were downregulated in CRC patients as well as in early-stage patients compared with healthy donors; they could serve as circulating biomarkers of diagnosis, including early diagnosis, for CRC, possessing favorable diagnostic efficiency. +circRNA target 34854210 hsa-mir-422a Diabetic Nephropathies Above results demonstrated that the high glucose-induced exo-circ_0125310 promoted cell proliferation and fibrosis in diabetic nephropathy via sponging miR-422a and targeting the IGF1R/p38 axis. +genetics_knock down_suppress 34854069 hsa-mir-766 Thyroid Cancer, Papillary Overexpression of miR +circulation_biomarker_diagnosis_ns 34854020 hsa-mir-6879 Thyroid Cancer, Papillary CONCLUSIONS The two plasma exosomal miRNAs (miR +circulation_biomarker_diagnosis_ns 34854020 hsa-mir-6774 Thyroid Cancer, Papillary CONCLUSIONS The two plasma exosomal miRNAs (miR +other 34853722 hsa-mir-494 Atherosclerosis We have previously shown that treatment with third-generation antisense oligonucleotides against miR3p (3GA-494) reduces atherosclerotic plaque progression and stabilizes lesions, both in early and established plaques, with reduced macrophage content in established plaques. +lncRNA target 34853647 hsa-mir-7 Spasm CONCLUSION: miR-7 downregulation is an early event in SPEM through regulation of TFF2 in human gastric mucosa. +lncRNA target 34853647 hsa-mir-7 Metaplasia CONCLUSION: miR-7 downregulation is an early event in SPEM through regulation of TFF2 in human gastric mucosa. +genetics_knock down_promote 34853631 hsa-mir-195 Neuroblastoma The inhibitory effects of hsa_circ_0013401 knockdown suppressed the proliferation, migration, and invasion and induced the apoptosis and autophagy of NB cells by targeting miR-195 to downregulate PAK2 expression. +other 34853624 hsa-mir-662 Atrial Fibrillation Subsequently, the hsa-miRCREB1-VIP axis was obtained, and the role of CREB1 and VIP in the development of AF after MI was further revealed by single-cell analysis and prediction model construction. +exosome 34853524 hsa-mir-216a Arthritis, Rheumatoid CONCLUSION: We concluded that MSC-derived exosomal circFBXW7 suppressed proliferation, migration and inflammatory response of RA-FLSs and damage of RA rats via sponging miR-216a-3p and release the activation of HDAC4. +lncRNA target 34853466 hsa-mir-139 Esophageal Squamous Cell Carcinoma In conclusion, GTF2E2 may serve as a novel biomarker for recurrence after surgery and a potential therapeutic target for ESCC patients, and it promotes ESCC progression via miR +exosome 34853307 hsa-mir-18b Breast Neoplasms Targeting CAFs-derived exosome miR-18b may be a potential treatment option to overcome breast cancer progression. +lncRNA target 34852712 hsa-mir-216a Urinary Bladder Neoplasms In conclusion, circFLNA inhibits the malignant phenotype of BCa cells and their stemness through miR-216a-3p/BTG2, thus suppressing BCa progression. +circRNA target 34852711 hsa-mir-298 Endometrial Neoplasms Our rescue assay data further revealed that hsa_circ_0005797 silencing inhibited EC cells proliferation and invasion via miR-298/CTNND1 signaling. In conclusion, our study confirmed hsa_circ_0005797 is a poor prognostic factor for EC and modulates EC phenotypes by regulating the hsa_circ_000579/miR-298/CTNND1 signaling, which provides potential treatment targets for EC. +exosome 34852710 hsa-mir-3977 Multiple Myeloma Collectively, our study indicates that exosomal circ-ATP10A is a valuable prognostic biomarker in MM and may promote MM angiogenesis by targeting hsa-miR +exosome 34852710 hsa-mir-6758 Multiple Myeloma Collectively, our study indicates that exosomal circ-ATP10A is a valuable prognostic biomarker in MM and may promote MM angiogenesis by targeting hsa-miR +exosome 34852710 hsa-mir-6804 Multiple Myeloma Collectively, our study indicates that exosomal circ-ATP10A is a valuable prognostic biomarker in MM and may promote MM angiogenesis by targeting hsa-miR +genetics_knock down_suppress 34852705 hsa-mir-567 Stomach Neoplasms This study aims to investigate the potential clinical function of long non-coding RNA CERS6-AS1 (lncRNA CERS6-AS1) integrated miR-567 in gastric cancer. After CERS6-AS1 knockdown, the expression level of miR-567 in gastric cancer tissues decreased, while the expression level of miR-567 increased. +circulation_biomarker_diagnosis_up 34851581 hsa-mir-223 Stomach Neoplasms CONCLUSIONS: Our results indicated that miR-21, miR-25, and miR-223 in plasma samples can be served as a potential noninvasive tool in detection of GC. +circulation_biomarker_diagnosis_up 34851581 hsa-mir-25 Stomach Neoplasms CONCLUSIONS: Our results indicated that miR-21, miR-25, and miR-223 in plasma samples can be served as a potential noninvasive tool in detection of GC. +circulation_biomarker_diagnosis_up 34851581 hsa-mir-21 Stomach Neoplasms CONCLUSIONS: Our results indicated that miR-21, miR-25, and miR-223 in plasma samples can be served as a potential noninvasive tool in detection of GC. +transcription factor target 34851490 hsa-mir-451a Cardiomyopathies In conclusion, these results indicate that miR-451a acts as a novel regulator of Ang II-induced cardiac fibrosis and inflammation by directly targeting TBX1, and may be a promising therapeutic target for treating hypertensive cardiac diseases. +transcription factor target 34851490 hsa-mir-451a Inflammation In conclusion, these results indicate that miR-451a acts as a novel regulator of Ang II-induced cardiac fibrosis and inflammation by directly targeting TBX1, and may be a promising therapeutic target for treating hypertensive cardiac diseases. +lncRNA target 34851489 hsa-mir-410 Brain Ischemia Conclusion Exhausting TUG1 could alleviate CI/R-induced inflammatory injury and apoptosis in brain tissues and BMECs via targeting miR-410/FOXO3 axis, suggesting an innovative perspective from cerebrovascular endothelial cells in the pathogenesis and treatment of CI/R. +lncRNA target 34851489 hsa-mir-410 Reperfusion Injury, Cerebral Ischemia Conclusion Exhausting TUG1 could alleviate CI/R-induced inflammatory injury and apoptosis in brain tissues and BMECs via targeting miR-410/FOXO3 axis, suggesting an innovative perspective from cerebrovascular endothelial cells in the pathogenesis and treatment of CI/R. +other 34851479 hsa-mir-223 von Hippel-Lindau Disease CONCLUSIONS: The present study demonstrated that the differences in the expression levels of miR-223 have the potential to be biomarkers to determine the poor prognosis in ccRCC. +other 34851479 hsa-mir-223 Carcinoma, Renal Cell CONCLUSIONS: The present study demonstrated that the differences in the expression levels of miR-223 have the potential to be biomarkers to determine the poor prognosis in ccRCC. +lncRNA target 34850965 hsa-mir-515 Stomach Neoplasms CONCLUSION: CircAKT3 promotes the malignant development of GC by activating SLC1A5 expression via targeting miR5p. +other 34850963 hsa-mir-466g Liver Cirrhosis Taken together, lncMBI52 induced liver fibrosis by regulating the miR466g/SMAD4 axis, which may provide a new possible strategy for liver fibrosis. +genetics_overexpression_promote 34850961 hsa-mir-204 Necrobiotic Disorders Moreover, NEAT1 overexpression counteracted miR204 mimicinduced injury, BRCC3 expression and NLRP3 inflammasome activationdependent pyroptosis. +transcription factor target 34850958 hsa-mir-451 Leukemia, Myeloid, Acute In conclusion, these results indicated that corilagin induced apoptosis and inhibited autophagy in HL60 cells by regulating the miR451/HMGB1 axis, and corilagin may be a novel therapeutic drug for the treatment of AML. +other 34850884 hsa-mir-4293 Femur Head Necrosis MIR4293 regulates a PPARG-related adipogenesis pathway relevant to S-ONFH. +other 34850884 hsa-mir-4293 Lupus Erythematosus, Systemic MIR4293 regulates a PPARG-related adipogenesis pathway relevant to S-ONFH. +circulation_biomarker_diagnosis_ns 34850865 hsa-mir-27b Non-alcoholic Fatty Liver Disease Finally, we confirmed that circulating miR-34a-5p and miR +circulation_biomarker_diagnosis_ns 34850865 hsa-mir-375 Non-alcoholic Fatty Liver Disease Finally, we confirmed that circulating miR-34a-5p and miR +circulation_biomarker_diagnosis_ns 34850865 hsa-mir-34a Non-alcoholic Fatty Liver Disease Finally, we confirmed that circulating miR-34a-5p and miR +other 34850664 hsa-mir-3681 Adenocarcinoma of Lung 3p to contribute to the malignant behaviors of LUAD cells. +circRNA target 34850570 hsa-mir-433 Carcinoma, Non-Small-Cell Lung 3p inhibitor reversed the inhibiting influence of circ_0008037 silencing on proliferation, migration, invasion, and the Warburg effect of NSCLC cells. +genetics_knock down_promote 34850542 hsa-mir-338 Cystadenocarcinoma, Serous, Ovarian We determine that knockdown of SBF2-AS1 inhibits SOC cell proliferation and invasion by sponging miR +lncRNA target 34850451 hsa-mir-195 Coronary Disease BACKGROUND: Long noncoding RNA urothelial cancer-associated 1 (lnc-UCA1) targets microRNA-26a (miR-26a) and microRNA-195 (miR-195) to participate in coronary heart disease (CHD) progression via regulation of vascular smooth muscle cell and microvascular endothelial cell viability and mobility. +lncRNA target 34850451 hsa-mir-26a Coronary Disease BACKGROUND: Long noncoding RNA urothelial cancer-associated 1 (lnc-UCA1) targets microRNA-26a (miR-26a) and microRNA-195 (miR-195) to participate in coronary heart disease (CHD) progression via regulation of vascular smooth muscle cell and microvascular endothelial cell viability and mobility. +transcription factor target 34850093 hsa-mir-144 Arthritis, Rheumatoid 3p could aggravate chondrocyte injury inflammatory response in RA via BMP2/PI3K/Akt axis. +genetics_overexpression_promote 34850088 hsa-mir-106b Arthritis, Rheumatoid CONCLUSIONS: miR-106b overexpression suppresses synovial inflammation and alleviates synovial damage; thus, it may be served as a potential therapeutic target for RA patients. +lncRNA target 34850055 hsa-mir-206 Myocardial Reperfusion Injury CONCLUSIONS: Our results elucidated that remifentanil alleviated myocardial I/R injury by miR3p/TLR4/NF-kappaB signalling axis. +circulation_biomarker_diagnosis_ns 34849458 hsa-mir-21 Carcinoma, Non-Small-Cell Lung The sensing performance and diagnostic performance of the mCLN assay were investigated using non-small cell lung cancer (NSCLC) as the disease model and exosomal microRNA-21 and TTF-1 mRNA as the biomarkers. The mCLN assay successfully distinguished NSCLC from normal controls by detecting significantly higher microRNA-21 and TTF-1 mRNA levels in exosomes from both NSCLC patient serum samples and A549 NSCLC cells than those from normal controls and BEAS-2B normal bronchial epithelial cells. +exosome 34849458 hsa-mir-21 Lung Neoplasms The sensing performance and diagnostic performance of the mCLN assay were investigated using non-small cell lung cancer (NSCLC) as the disease model and exosomal microRNA-21 and TTF-1 mRNA as the biomarkers. +transcription factor target 34849149 hsa-mir-183 Breast Neoplasms 5p supplies a promising target for BC therapy. +genetics_GWAS 34848810 hsa-mir-618 Colorectal Neoplasms In summary, polymorphism rs2682818 participated in the progression of CRC via affecting the expression of mature miR-618 in CRC cells, and miR-618 inhibited the progression of CRC via targeting TIMP1expression. +exosome 34848693 hsa-mir-1249 Diabetes Mellitus, Type 2 This study reveals an emerging role for NK-derived exosomal miR3p in remission of insulin resistance, and provides a series of potential therapeutic targets in type 2 diabetes. +exosome 34848693 hsa-mir-1249 Inflammation This study reveals an emerging role for NK-derived exosomal miR3p in remission of insulin resistance, and provides a series of potential therapeutic targets in type 2 diabetes. +genetics_overexpression_promote 34848471 hsa-mir-188 Breast Neoplasms Moreover, miRNA-3188 overexpression sensitized breast cancer cells to ionizing radiation (IR) by down-regulating Rictor and p-AKT. +lncRNA target 34848464 hsa-mir-181b Ehlers-Danlos Syndrome, musculocontractural type 1 CONCLUSION: CTAB attenuates the mesenchymal characteristics through upregulation of TIMP3 by inhibiting the canonical TGF-beta/Smad/miR-181b/TIMP3 signaling involved in extracellular matrix remodeling in SCC4 cells and might be a promising anti-metastatic therapeutic agent for TSCC. +lncRNA target 34848464 hsa-mir-181b Carcinoma, Basal Cell CONCLUSION: CTAB attenuates the mesenchymal characteristics through upregulation of TIMP3 by inhibiting the canonical TGF-beta/Smad/miR-181b/TIMP3 signaling involved in extracellular matrix remodeling in SCC4 cells and might be a promising anti-metastatic therapeutic agent for TSCC. +genetics_overexpression_promote 34848272 hsa-mir-338 Glioma Additionally, silencing MYT1L produced similar effects as overexpressing miRNA +other 34847936 hsa-mir-145 Ovarian Neoplasms 5p to improve the expression of ZEB2 in ovarian cancer. +other 34847936 hsa-mir-383 Ovarian Neoplasms 5p to improve the expression of ZEB2 in ovarian cancer. +circulation_biomarker_diagnosis_up 34847832 hsa-mir-188 Diabetic Nephropathies 3p antagonists is expected to be an effective therapeutic strategy for DN.Abbreviations DN: diabetic nephropathy; Type I DN: DN in Type I diabetes; STZ: streptozocin; ROS: reactive oxygen species; NcRNAs: non-coding RNAs; UTR: untranslated regions; NC: negative control; BUN: blood urea nitrogen; BUA: blood uric acid; Ucr: urine creatinine; Scr: serum creatinine; PAS: Periodic Acid-Schiff; IF: Immunofluorescence; FISH: Fluorescence in situ hybridization; TUG1: taurine upregulated gene 1; GPX: Glutathione Peroxidase; GPX4: glutathione peroxidase 4; EMT: epithelial-mesenchymal transition. +exosome 34847690 hsa-mir-136 Fractures, Bone CONCLUSION: BMSC-derived exosomes carrying miR +other 34846081 hsa-mir-5787 Colorectal Neoplasms We found that the expression of miRNA-5787 was correlated with reciprocal expression of two mRNAs, that is, SRRM2 and POLR2J3, in SSL samples. +other 34846081 hsa-mir-6753 Colorectal Neoplasms 3p/OLFM4, were retained in CRC with an MSI phenotype. +other 34846081 hsa-mir-182 Colorectal Neoplasms In TSA samples, two pairs of miRNAs/mRNAs showing opposite expression patterns, that is, miRNA5p/ETF1 and miRNA-200b-3p/MYB, were identified. +other 34846081 hsa-mir-222 Colorectal Neoplasms 3p/OLFM4, were retained in CRC with an MSI phenotype. +other 34846081 hsa-mir-200b Colorectal Neoplasms In TSA samples, two pairs of miRNAs/mRNAs showing opposite expression patterns, that is, miRNA5p/ETF1 and miRNA-200b-3p/MYB, were identified. +transcription factor target 34845965 hsa-mir-37 Inflammation miR-337 and miR-375 inhibition reversed the effects of PRP of reducing tenderness and thermal pain thresholds in OA rats. +transcription factor target 34845965 hsa-mir-375 Osteoarthritis miR-337 and miR-375 inhibition reversed the effects of PRP of reducing tenderness and thermal pain thresholds in OA rats. +transcription factor target 34845965 hsa-mir-375 Inflammation miR-337 and miR-375 inhibition reversed the effects of PRP of reducing tenderness and thermal pain thresholds in OA rats. +transcription factor target 34845965 hsa-mir-37 Osteoarthritis miR-337 and miR-375 inhibition reversed the effects of PRP of reducing tenderness and thermal pain thresholds in OA rats. +circRNA target 34845670 hsa-mir-345 Pre-Eclampsia Our data demonstrate the upregulation of circ_0008726 in PE placenta, which inhibits the migration, invasion, and EMT of HTR-8/SVneo cells by targeting miR +other 34845193 hsa-mir-33a Myocardial Reperfusion Injury Circ-NNT promotes pyroptosis and myocardial I/R injury by acting as a miR-33a-5p sponge to regulate USP46. +circRNA target 34845164 hsa-mir-149 Breast Neoplasms Interference of circATXN7 inhibited breast cancer progression and doxorubicin resistance via mediating miR +lncRNA target 34845162 hsa-mir-107 Squamous Cell Carcinoma of Head and Neck Circ_0005033 was oncogenic in LSCC by regulating cell progression and Cisplatin sensitivity at least via miR-107/IGF1R axis. +other 34844630 hsa-mir-193b Colorectal Neoplasms Long noncoding RNA CRART16 confers 5-FU resistance in colorectal cancer cells by sponging miR-193b-5p. +circRNA target 34844614 hsa-mir-30 Carcinoma, Hepatocellular CONCLUSIONS: The acceleration of HCC progression and metastasis by circSLC7A11 through the circSLC7A11/miR +other 34844494 hsa-mir-124 Glaucoma based advanced therapies might be a potential avenue in the treatment of glaucomatous neurodegeneration. +lncRNA target 34844105 hsa-mir-378b Liver Diseases A previous study indicated that microRNA-378b (miR-378b) plays a critical role in controlling hepatic insulin resistance by targeting insulin receptor (IR) and p110alpha in alcoholic liver disease (ALD). Taken together, MFA exhibited a positive effect against ALD by attenuating the inhibition of miR-378b on IR/p110alpha and partly activating the insulin signaling to alleviate alcohol-induced hepatic insulin resistance. +lncRNA target 34844105 hsa-mir-378b Adrenoleukodystrophy A previous study indicated that microRNA-378b (miR-378b) plays a critical role in controlling hepatic insulin resistance by targeting insulin receptor (IR) and p110alpha in alcoholic liver disease (ALD). Taken together, MFA exhibited a positive effect against ALD by attenuating the inhibition of miR-378b on IR/p110alpha and partly activating the insulin signaling to alleviate alcohol-induced hepatic insulin resistance. +lncRNA target 34844105 hsa-mir-378b Liver Diseases, Alcoholic A previous study indicated that microRNA-378b (miR-378b) plays a critical role in controlling hepatic insulin resistance by targeting insulin receptor (IR) and p110alpha in alcoholic liver disease (ALD). +circulation_biomarker_diagnosis_ns 34843716 hsa-mir-194 Acute Liver Injury The two microRNAs miR-192 and miR-194 are abundantly expressed in the liver and are considered serum biomarkers of liver injury. +other 34843522 hsa-mir-338 Glioblastoma In conclusion, H19 and hsa-miR3P regulate NRP1 expression, and this pathway plays an important role in GBM. +transcription factor target 34843094 hsa-mir-199a Cardiomyopathies miR-199a-5p acted as an inhibitor directly targeted hypoxia-inducible factor-1 (HIF1alpha) expression, which was higher in the cardiomyocyte injury model than that in healthy myocardial cells. +circulation_biomarker_diagnosis_ns 34843038 hsa-mir-574 Liver Cirrhosis 5p expression in serum exosomes is positively correlated with collagen deposition and HSC activation in liver tissues during liver fibrosis.Serum exosomes potentially activate HSC through the transfer of miR +other 34842937 hsa-mir-342 Liver Neoplasms OBJECTIVE: This study aims to explore the effects of miR3p on liver cancer stem cells (LCSC) and related mechanism. +genetics_knock down_promote 34842045 hsa-mir-338 Stomach Neoplasms 5p inhibitor or METTL3 overexpression could rescue the inhibitory effect of LINC00240 knockdown on cell proliferation and migration, and inhibit the apoptosis induction in GC cells. +circulation_biomarker_diagnosis_ns 34841929 hsa-mir-18a Atherosclerosis ROC curve suggested the high diagnostic value of serum miR-18a-5p for AS, with the AUC of 0.894. +lncRNA target 34841662 hsa-mir-576 Colorectal Neoplasms CONCLUSIONS: Hsa_circ_0001666 suppresses CRC progression through the miR +lncRNA target 34841440 hsa-mir-16 Ischemia Further experiments revealed that GATA4 could bind to the promoter region of SNHG1 and subsequently regulated the expression levels of SNHG1, indicating the important role of the positive feedback loop of SNHG1/miR165p/GATA4 in cardiomyocyte ischemic injury. To conclude, the present study revealed the protective effect of the SNHG1/miR165p/GATA4 positive feedback loop on cardiomyocyte injury induced by H/R and provided a potential therapeutic target for ischemic cardiomyocyte injury. +transcription factor target 34841435 hsa-mir-671 Carcinoma, Non-Small-Cell Lung The proliferative, migratory and invasive abilities of NSCLC cells were suppressed following transfection with miR6715p mimics and promoted by the miR6715p inhibitor compared with those in the respective control groups. +other 34841287 hsa-mir-216a Pancreatic Carcinoma Collectively, our study gives insights into how beta-cell mass and acinar cell growth are modulated by a pancreas-specific miRNA and also suggests miR-216a as a potential biomarker for diagnosis of pancreatic diseases. +transcription factor target 34840985 hsa-mir-125b Stomach Neoplasms The potential target overlap genes of miR-199a-3p/miR-199b-3p, miR-125b-5p, and miR-199a-5p were 4 genes (SH3GL2, ATP4B, CTSE, and SORBS2), 7 genes (SLC7A8, RNASE4, ESRRG, PGC, MUC6, Fam3B, and FMO5), and 6 genes (CHGA, PDK4, TMPRSS2, CLIC6, GPX3, and PSCA), respectively. +transcription factor target 34840985 hsa-mir-199a Stomach Neoplasms The potential target overlap genes of miR-199a-3p/miR-199b-3p, miR-125b-5p, and miR-199a-5p were 4 genes (SH3GL2, ATP4B, CTSE, and SORBS2), 7 genes (SLC7A8, RNASE4, ESRRG, PGC, MUC6, Fam3B, and FMO5), and 6 genes (CHGA, PDK4, TMPRSS2, CLIC6, GPX3, and PSCA), respectively. +transcription factor target 34840985 hsa-mir-199b Stomach Neoplasms The potential target overlap genes of miR-199a-3p/miR-199b-3p, miR-125b-5p, and miR-199a-5p were 4 genes (SH3GL2, ATP4B, CTSE, and SORBS2), 7 genes (SLC7A8, RNASE4, ESRRG, PGC, MUC6, Fam3B, and FMO5), and 6 genes (CHGA, PDK4, TMPRSS2, CLIC6, GPX3, and PSCA), respectively. +genetics_knock down_promote 34839824 hsa-mir-342 Carcinoma, Non-Small-Cell Lung 3p overexpression suppressed the malignant behaviors of NSCLC cells largely by downregulating ZEB2. +circulation_biomarker_diagnosis_up 34839589 hsa-mir-20b Duane Retraction Syndrome RESULTS: CircZNF532 and STAT3 were upregulated but miR-20b-5p was downregulated in the serum samples of patients with DR and HG-induced ARPE-19 cells. +lncRNA target 34839459 hsa-mir-136 Reperfusion Injury, Cerebral Ischemia In conclusion, we demonstrated that SNHG12 acts as a ceRNA of miR5p, thereby targets and regulates the expression of Bcl-2, which attenuates cerebral ischemia/reperfusion injury via activation of the PI3K/AKT pathway. +other 34839449 hsa-mir-19a Prostatic Neoplasms CONCLUSIONS: Collectively, our results uncover a previously unrecognized novel mechanism on PCA3 upregulation in prostate cancer and proved that miR-19a and miR-421 might be responsible for the increased expression of PCA3, indicating that both miRNAs might be novel candidates for prostate cancer diagnosis and therapy. +other 34839449 hsa-mir-421 Prostatic Neoplasms CONCLUSIONS: Collectively, our results uncover a previously unrecognized novel mechanism on PCA3 upregulation in prostate cancer and proved that miR-19a and miR-421 might be responsible for the increased expression of PCA3, indicating that both miRNAs might be novel candidates for prostate cancer diagnosis and therapy. +target gene 34839107 hsa-mir-362 Ovarian Neoplasms miR-362-3p suppresses ovarian cancer by inhibiting LRP8. +exosome 34839044 hsa-mir-223 Supranuclear Palsy, Progressive 5p, discriminated PD from HC (area under the curve of 0.75), and a set of three exosomal miRNAs, miR +exosome 34839044 hsa-mir-21 Parkinson Disease 5p, discriminated PD from HC (area under the curve of 0.75), and a set of three exosomal miRNAs, miR +exosome 34839044 hsa-mir-199a Parkinson Disease 5p, discriminated PD from HC (area under the curve of 0.75), and a set of three exosomal miRNAs, miR +exosome 34839044 hsa-mir-199a Supranuclear Palsy, Progressive 5p, discriminated PD from HC (area under the curve of 0.75), and a set of three exosomal miRNAs, miR +exosome 34839044 hsa-mir-22 Supranuclear Palsy, Progressive 5p, discriminated PD from HC (area under the curve of 0.75), and a set of three exosomal miRNAs, miR +exosome 34839044 hsa-mir-22 Parkinson Disease 5p, discriminated PD from HC (area under the curve of 0.75), and a set of three exosomal miRNAs, miR +exosome 34839044 hsa-mir-425 Parkinson Disease 5p, discriminated PD from HC (area under the curve of 0.75), and a set of three exosomal miRNAs, miR +exosome 34839044 hsa-mir-21 Supranuclear Palsy, Progressive 5p, discriminated PD from HC (area under the curve of 0.75), and a set of three exosomal miRNAs, miR +exosome 34839044 hsa-mir-425 Supranuclear Palsy, Progressive 5p, discriminated PD from HC (area under the curve of 0.75), and a set of three exosomal miRNAs, miR +exosome 34839044 hsa-mir-223 Parkinson Disease 5p, discriminated PD from HC (area under the curve of 0.75), and a set of three exosomal miRNAs, miR +genetics_knock down_promote 34838997 hsa-mir-195 Liver Cirrhosis 3p inhibit the expression of phosphatase and tension homolog deleted on chromosome 10 (PTEN), a negative regulator of the PI3K/Akt/mTOR signaling pathway in liver fibrosis, thereby contributing to HSC activation and proliferation and promoting the expression of profibrotic genes, such as alpha-SMA and collagen I, in LX-2 cells, which accelerates the accumulation of fibrous extracellular matrix deposition in the liver, while knockdown of miR +other 34838994 hsa-mir-146a Acute Lung Injury Free radical scavenging cerium oxide nanoparticles (CNP) conjugated to the anti-inflammatory microRNA-146a (miR146a), termed CNP-miR146a, have been shown to prevent acute lung injury in a pre-clinical model. +exosome 34838826 hsa-mir-942 Adenocarcinoma of Lung Mechanistically, exosomal miR-942 regulates FOXO1 protein expression by binding to the 3'-UTR region of FOXO1 and further alleviates beta-catenin inhibition in LUAD cells. +lncRNA target 34838715 hsa-mir-34a Non-alcoholic Fatty Liver Disease Finally, we found a strong association of CRTC2, miR-34a and mTORC1 activity in the NAFLD patients in humans, demonstrating a conservation of signaling pathways among species. CONCLUSIONS These data collectively suggest that diet-induced activation of CRTC2 instigates the progression of NAFLD by activating miR-34a-mediated lipid accumulation in the liver via the simultaneous induction of lipogenesis and inhibition of lipid catabolism. +lncRNA target 34838479 hsa-mir-182 Colorectal Neoplasms CONCLUSION: E2F4-stimulated AGAP2-AS1 aggravated CRC development through regulating miR +circulation_biomarker_diagnosis_ns 34838331 hsa-mir-155 COVID-19 Beside the routine laboratory work and chest computed tomography (CT) scans of COVID-19 patients, plasma miR-155 expression level was measured using reverse transcription quantitative real-time PCR (RT-qPCR) technique. +lncRNA target 34838052 hsa-mir-7 Non-alcoholic Fatty Liver Disease CONCLUSIONS: Hepatic sEVs contribute to endothelial hyperpermeability in coronary microvessels by delivering novel-miR-7 and targeting the LAMP1/Cathepsin B/NLRP3 inflammasome axis during NAFLD. +genetics_overexpression_suppress 34838029 hsa-mir-29c Cachexia Overexpression of miR-29c mitigated the cachectic phenotype. +genetics_overexpression_suppress 34838029 hsa-mir-29c Leukemia Overexpression of miR-29c mitigated the cachectic phenotype. +target gene 34838007 hsa-let-7a Breast Neoplasms Let-7a induces metabolic reprogramming in breast cancer cells via targeting mitochondrial encoded ND4. +other 34837947 hsa-mir-1182 Ovarian Neoplasms circ_MUC16 attenuates the effects of Propofol to promote the aggressive behaviors of ovarian cancer by mediating the miR-1182/S100B signaling pathway. +other 34837929 hsa-mir-98 Breast Neoplasms In clinical research, we found that decreased miR5p level or increased IGF2 level significantly associated with poor treatment response and poor overall survival (OS), poor recurrence free survival (RFS) and poor distant metastasis-free survival (DMFS) in HER2-positive breast cancer. +other 34837916 hsa-mir-146a Primary Myelofibrosis CONCLUSION: miR-146a rs2431697 TT genotype is associated with high risk of MF progression in MPN patients. +other 34837916 hsa-mir-146a Bone Marrow Myelofibrosis CONCLUSION: miR-146a rs2431697 TT genotype is associated with high risk of MF progression in MPN patients. +circulation_biomarker_prognosis_up 34837907 hsa-mir-106a Breast Neoplasms METHODS: Sera and plasma of 30 normal women and 50 women with breast carcinoma were assayed for MiR-106a by RT-qPCR as well as levels of Hb, WBCs and platelets count and RAF-1 by solid phase enzyme-linked immunosorbent assay (ELISA). +genetics_knock down_promote 34837887 hsa-mir-524 Laryngeal Neoplasms Taken together, knockdown of NEAT1 suppressed laryngocarcinoma cell growth and metastasis by miR5p/HDAC1/PTEN/AKT signal pathway, which provided a potential therapeutic target for laryngocarcinoma. +circulation_biomarker_diagnosis_ns 34837851 hsa-mir-222 Myocardial Infarction Moreover, serum miR-222 levels were significantly reduced in MI patients, as well as in MI patients that were readmitted to the hospital and/or died compared to those not. +other 34837760 hsa-mir-23 Glioblastoma 3p or has-miR-19b-3p constituted a diagnostic signature to distinguish GBM from controls, with the area under the ROC curve nearly approximate to 1. +other 34837760 hsa-mir-19b Glioblastoma 3p or has-miR-19b-3p constituted a diagnostic signature to distinguish GBM from controls, with the area under the ROC curve nearly approximate to 1. +other 34837760 hsa-mir-183 Glioblastoma 3p or has-miR-19b-3p constituted a diagnostic signature to distinguish GBM from controls, with the area under the ROC curve nearly approximate to 1. +other 34837760 hsa-mir-98 Glioblastoma 3p or has-miR-19b-3p constituted a diagnostic signature to distinguish GBM from controls, with the area under the ROC curve nearly approximate to 1. +other 34837708 hsa-mir-16 Breast Neoplasms High variance in the stability value (SV) of miR-16 expression levels confirmed its inappropriateness as a control gene in breast cancer. +other 34837692 hsa-mir-378a Uterine Cervical Neoplasms The core gene granzyme B (GZMB) was screened and the CC-associated regulatory axis, GZMB/ miR-378a/TRIM52-AS1, was constructed, which may promote CC progression, and further experimentation is needed to validate these results. +circRNA target 34837683 hsa-mir-326 Carcinoma, Non-Small-Cell Lung CONCLUSION: This work reveals that circ_0000517 is implicated in NSCLC cell growth and metastasis through the modulation of miR-326/miR +circRNA target 34837683 hsa-mir-30 Carcinoma, Non-Small-Cell Lung CONCLUSION: This work reveals that circ_0000517 is implicated in NSCLC cell growth and metastasis through the modulation of miR-326/miR +other 34837628 hsa-mir-29a Peripheral Nerve Injuries Here, we examine the temporal expression patterns of miR-29a-3p after peripheral nerve injury and demonstrate significant up-regulation of miR-29a-3p in injured sciatic nerves. +other 34837628 hsa-mir-29a Sciatic Neuropathy Our results disclose the vital role of miR-29a-3p/PMP22 in regulating Schwann cell phenotype following sciatic nerve injury and shed light on the mechanistic basis of peripheral nerve regeneration. +circulation_biomarker_diagnosis_ns 34837469 hsa-mir-21 Lung Neoplasms CONCLUSION: MicroRNA-21 in serum or sputum was a promising biomarker for lung cancer identification with relative high diagnostic sensitivity and specificity. +exosome 34837453 hsa-mir-450b Adenocarcinoma of Lung A d-signature comprising four EV-derived miRNAs (hsa-miR-106b-3p, hsa-miR-125a-5p, hsa-miR-3615, and hsa-miR-450b-5p) was developed for the early detection of LUAD. +exosome 34837453 hsa-mir-615 Adenocarcinoma of Lung A d-signature comprising four EV-derived miRNAs (hsa-miR-106b-3p, hsa-miR-125a-5p, hsa-miR-3615, and hsa-miR-450b-5p) was developed for the early detection of LUAD. +exosome 34837453 hsa-mir-106b Adenocarcinoma of Lung A d-signature comprising four EV-derived miRNAs (hsa-miR-106b-3p, hsa-miR-125a-5p, hsa-miR-3615, and hsa-miR-450b-5p) was developed for the early detection of LUAD. +exosome 34837453 hsa-mir-125a Adenocarcinoma of Lung A d-signature comprising four EV-derived miRNAs (hsa-miR-106b-3p, hsa-miR-125a-5p, hsa-miR-3615, and hsa-miR-450b-5p) was developed for the early detection of LUAD. +circulation_biomarker_diagnosis_ns 34837150 hsa-mir-1290 Hyperlipidemias METHODS AND RESULTS: The current study showed that the expressions of miR-1290 were high in serum of patients with hyperlipidemia. +other 34837150 hsa-mir-1290 Angelman Syndrome However, the role of miR-1290 in atherosclerosis (AS) is still unclear. +other 34837147 hsa-mir-1280 Colorectal Neoplasms CONCLUSION: The present study demonstrated that low expression of tRF/miR-1280, tRNA-Val(AAC/CAC), and tRNA-Asp(GTC) was significantly associated with metastatic stage and more aggressive tumor behavior of CRC disease. +lncRNA target 34837127 hsa-mir-17 Wounds and Injuries These results exhibited that circ_0084443 suppressed the TGF-beta1-induced keratinocyte migration by regulating the miR3p/FOXO4 axis, suggesting the application potential of circ_0084443 in wound-healing-related diseases. +genetics_knock down_promote 34837026 hsa-mir-199a Ovarian Neoplasms We established DDR1 to be a direct target of miR-199a-5p and that ST09-induced DDR1 loss in these ovarian cancer cells resulted in the inactivation of its downstream MMP activation, migration, EMT, and prosurvival NF-kappaB pathway. +genetics_overexpression_promote 34836796 hsa-mir-181b Fatty Liver, Alcoholic RESULTS: MiR-181b-5p and PRMT1 were elevated while PIAS1 was reduced in AFLD rat liver tissues, miR-181b-5p inhibition, PIAS1 overexpression or PRMT1 inhibition improved liver function, attenuated inflammation, oxidative stress, pathological changes and hepatocyte apoptosis in AFLD rat liver tissues. +transcription factor target 34836745 hsa-mir-22 Hypertension, Pulmonary 3p as a regulator can be targeted by osthole to greatly restore dysregulated lipid metabolism thus to alleviate pulmonary vascular remodeling in PAH, which provides novel insight into the potential therapeutic target for PAH, further highlights the development potential of osthole derived new drug against PAH. +transcription factor target 34836745 hsa-mir-22 Vascular Remodeling 3p as a regulator can be targeted by osthole to greatly restore dysregulated lipid metabolism thus to alleviate pulmonary vascular remodeling in PAH, which provides novel insight into the potential therapeutic target for PAH, further highlights the development potential of osthole derived new drug against PAH. +lncRNA target 34836544 hsa-mir-148a Ovarian Neoplasms CONCLUSION: SNHG20 promoted invasion and migration of OC via targeting miR-148a/ROCK1 axis. +other 34834557 hsa-mir-101 Mesothelioma, Malignant 3p due to a significant association of its higher expression and increased overall survival (OS) of MM patients. +genetics_overexpression_promote 34834139 hsa-mir-654 Carcinoma, Renal Cell 5p overexpression or YY1 inhibition recovered ccRCC cell functions that had been previously impaired by LINC02532 overexpression. +transcription factor target 34834018 hsa-mir-370 Obesity 3p may result from the inhibition of saturated fatty acids that promote the accumulation of polyunsaturated fatty acids. +other 34832969 hsa-mir-223 Alzheimer Disease 5p expression is increased in AD, but this does not result in down-regulation of NLRP3 inflammasome expression and of IL-1beta and IL-18 production. +other 34832969 hsa-mir-7 Alzheimer Disease 5p expression is increased in AD, but this does not result in down-regulation of NLRP3 inflammasome expression and of IL-1beta and IL-18 production. +other 34831451 hsa-mir-22 Diabetes Mellitus MiR3p was significantly downregulated in diabetic SMGs and HG-treated SMG-C6 cells. +other 34831427 hsa-mir-27a Simpson-Golabi-Behmel syndrome type 1 Both strands of miR-27a, miR-27a-3p and -5p, were downregulated during the adipogenic differentiation of Simpson-Golabi-Behmel syndrome (SGBS) cells, human multipotent adipose-derived stem cells (hMADS), and human primary adipose-derived stromal cells (hASCs). +transcription factor target 34831374 hsa-mir-208a Mitochondrial Diseases MiR 208a may be a therapeutic target to promote mitochondrial biogenesis in chronic diseases associated with mitochondrial defects. +other 34831374 hsa-mir-208a Diabetes Mellitus In summary, miR 208a regulates mitochondrial biogenesis and function in cardiomyocytes exposed to diabetic conditions. +transcription factor target 34831374 hsa-mir-208a Chronic Disease MiR 208a may be a therapeutic target to promote mitochondrial biogenesis in chronic diseases associated with mitochondrial defects. +transcription factor target 34831232 hsa-mir-155 Leukemia, Lymphocytic, Chronic, B-Cell Inhibition of miR +tissue_expression_ns 34831232 hsa-mir-155 Biotinidase Deficiency Our studies suggest that miR5p is involved in BTLA deficiency, affecting proliferation of CLL B cells, which may be one of the mechanisms responsible for CLL pathogenesis. +transcription factor target 34831071 hsa-mir-2478 Melanoma We found that Rap1a is a direct target gene of miR-2478 in melanoma cells and melanocytes. +lncRNA target 34831059 hsa-mir-17 Pulmonary Fibrosis This study assessed the role of miR17-92 in IPF-fibroblast proliferation and its modification by treprostinil. These data suggest that proliferation control via miR17-92 and C/EBP-beta is disrupted in IPF-fibroblasts. +transcription factor target 34831008 hsa-mir-146a Mycosis Fungoides We found miR-146a and miR-21 to be significantly upregulated, and miR-708 the most significantly downregulated miR in LCT-MF. Moreover, our data indicated that miR-146a, -21 and -708 are associated with the immunosuppressive TME in LCT-MF. +exosome 34831007 hsa-mir-1227 Prostatic Neoplasms Here, we show that miR-1227, which is enriched in prostate cancer EVs, compared to the cell of origin, but not in EVs derived from prostate benign epithelial cells, induces the shedding of large EVs (such as large oncosomes), while inhibiting the shedding of small EVs (such as exosomes). +other 34830882 hsa-mir-486 Breast Neoplasms Colon cancer decreased microRNA-486 expression, increasing PTEN in tibialis anterior muscle (TA), decreasing the PI3K/mTOR protein pathway, body and muscle wasting, fibers' cross-sectional area and muscle dysfunction, that were not preserved by AET. +other 34830882 hsa-mir-486 Colonic Neoplasms Colon cancer decreased microRNA-486 expression, increasing PTEN in tibialis anterior muscle (TA), decreasing the PI3K/mTOR protein pathway, body and muscle wasting, fibers' cross-sectional area and muscle dysfunction, that were not preserved by AET. +genetics_knock down_promote 34830864 hsa-mir-125b Colorectal Neoplasms Overexpression of miR-125b in CRC cells enhanced migration capacity, while knockdown of miR-125b decreased migration and invasion. +circRNA target 34830863 hsa-mir-1178 Squamous Cell Carcinoma of Head and Neck Furthermore, circRNA-102450 directly bound to, and consequently down-regulated, miR-1178 in OSCC cells. Taken together, circRNA-102450 has a tumor suppressive effect via the circRNA-102450/miR-1178 axis and may be a novel potential marker of RLNM in OSCC patients. +transcription factor target 34830317 hsa-mir-26a-2 Myositis IPA also effectively protected against LPS-induced C2C12 cells inflammation by activating Pregnane X Receptor and restoring the inhibited miR-26a +circulation_biomarker_diagnosis_ns 34830203 hsa-mir-23a Macular Degeneration 5p) showed higher expression in the serum of dry AMD patients than wet AMD patients and compared with healthy controls. +circulation_biomarker_diagnosis_ns 34830203 hsa-let-7a Macular Degeneration 5p) showed higher expression in the serum of dry AMD patients than wet AMD patients and compared with healthy controls. +circulation_biomarker_diagnosis_ns 34830203 hsa-let-7d Macular Degeneration 5p) showed higher expression in the serum of dry AMD patients than wet AMD patients and compared with healthy controls. +circulation_biomarker_diagnosis_ns 34830203 hsa-mir-874 Macular Degeneration 5p) showed higher expression in the serum of dry AMD patients than wet AMD patients and compared with healthy controls. +circulation_biomarker_diagnosis_ns 34830203 hsa-mir-361 Macular Degeneration 5p) showed higher expression in the serum of dry AMD patients than wet AMD patients and compared with healthy controls. +circulation_biomarker_diagnosis_ns 34830203 hsa-mir-27b Macular Degeneration 5p) showed higher expression in the serum of dry AMD patients than wet AMD patients and compared with healthy controls. +other 34830196 hsa-mir-16 Prostatic Neoplasms miR-195/miR-16 were negatively associated with PD-L1 expression and positively correlated to longer biochemical recurrence-free survival; they also enhanced the radiotherapy efficacy in PC cell lines. +other 34830196 hsa-mir-195 Prostatic Neoplasms miR-195/miR-16 were negatively associated with PD-L1 expression and positively correlated to longer biochemical recurrence-free survival; they also enhanced the radiotherapy efficacy in PC cell lines. +other 34830057 hsa-mir-146a Arthritis, Rheumatoid Moreover, miR-146a significantly decreased pro-autoimmune IL-17 cytokine expression in RA. +transcription factor target 34830057 hsa-mir-34a Arthritis, Rheumatoid In a murine model, miR-34a inhibition can ameliorate the arthritis score. +genetics_GWAS 34830054 hsa-mir-223 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Here, we examine the genetic structure and biological roles of CLEC12A-MIR223HG, a novel chimeric transcript produced by the fusion of the cell surface receptor CLEC12A and the miRNA-223 host gene (MIR223HG), first identified in chronic myeloid leukemia (CML) patients. Surprisingly, we observed that CLEC12A-MIR223HG is not just expressed in CML, but also in a variety of normal tissues and cell lines. +other 34829725 hsa-mir-92b Depression Over-expression of the miR-15b-5p/miR-92b-3p may be a new therapeutic strategy for OSA-related depression. +other 34829725 hsa-mir-92b Sleep Apnea, Obstructive Over-expression of the miR-15b-5p/miR-92b-3p may be a new therapeutic strategy for OSA-related depression. +other 34829725 hsa-mir-15b Sleep Apnea, Obstructive Over-expression of the miR-15b-5p/miR-92b-3p may be a new therapeutic strategy for OSA-related depression. +other 34829725 hsa-mir-15b Depression Over-expression of the miR-15b-5p/miR-92b-3p may be a new therapeutic strategy for OSA-related depression. +other 34828420 hsa-mir-6888 Non-alcoholic Fatty Liver Disease We have selected EDN1/TNF/MAPK3/EP300/hsa-miR5p/lncRNA RABGAP1L-DT-206 RNA panel from bioinformatics microarrays databases related to STING pathway and NAFLD/NASH pathogenesis. +other 34828420 hsa-mir-6888 Carcinoma, Hepatocellular We have selected EDN1/TNF/MAPK3/EP300/hsa-miR5p/lncRNA RABGAP1L-DT-206 RNA panel from bioinformatics microarrays databases related to STING pathway and NAFLD/NASH pathogenesis. +other 34828332 hsa-mir-629 Prostatic Neoplasms 5p, and let-7d-5p. +other 34828332 hsa-mir-194 Prostatic Neoplasms 5p, and let-7d-5p. +other 34828332 hsa-let-7d Prostatic Neoplasms 5p, and let-7d-5p. +circulation_biomarker_diagnosis_up 34828307 hsa-mir-1206 Pancreatic Carcinoma Cytoplasmic circ_0092367 could directly repress the levels of miR-1206 and thus upregulate the expression of ESRP1, thereby inhibiting EMT and enhancing the sensitivity of PC cells to gemcitabine treatment. +other 34828282 hsa-mir-137 Breast Neoplasms Mechanistic exploration revealed that a potential ncRNA-mRNA axis, involving LINC01128/LINC01140/SGMS1-AS1/LINC00667-miR-137/mi might be partially responsible for MUC14's functions in breast cancer. +lncRNA target 34828265 hsa-mir-92a Cholangiocarcinoma To elucidate the detailed regulatory mechanism, miR-92a-3p is screened and identified as a negative regulatory small RNA targeting NOV, and further experimental validation demonstrates that miR-92a-3p contributes to NOV-mediated migration and invasion of ICC via the Notch signaling pathway. +circulation_biomarker_diagnosis_ns 34827715 hsa-mir-4454 Cardiomyopathy, Hypertrophic 3p and miR-4454 levels are elevated in the plasma of HCM patients. +other 34827683 hsa-mir-629 Coronary Artery Disease 5p were significantly correlated with acute myocardial infarction. +other 34827683 hsa-mir-98 Coronary Artery Disease 5p were significantly correlated with acute myocardial infarction. +other 34827683 hsa-mir-5701 Coronary Artery Disease Of particular interest, miR-5701 was positively correlated with hypertension, hypercholesterolemia, and diabetes. +other 34827618 hsa-mir-6300 Fusariosis These results imply that miR319a-JRL3, miR6300-BEE1, miR6300-DAHP1 and miR6300-PERK2 regulate cucumber defenses against FW, and provide the gene resources that may be useful for breeding programs focused on developing new cucumber varieties with enhanced resistance to FW. +other 34827618 hsa-mir-19a Fusariosis These results imply that miR319a-JRL3, miR6300-BEE1, miR6300-DAHP1 and miR6300-PERK2 regulate cucumber defenses against FW, and provide the gene resources that may be useful for breeding programs focused on developing new cucumber varieties with enhanced resistance to FW. +other 34827608 hsa-mir-191 Aortic Aneurysm, Abdominal Past studies have implicated microRNAs in the development of AAA; therefore in this project, we measured miR-191 levels in AAA patients and compared them with a control group. Subsequent pathway analysis established that some of the perturbations mediated by miR-191 can be explained by several processes which have long been observed and described in literature as accompanying the development of abdominal aortic aneurysms. +lncRNA target 34826437 hsa-mir-17 Carcinoma, Hepatocellular hA-MSCs modulation may be partially achieved via dysregulation of intracellular miR17-5P and 615-5p expression, suggesting an important role for miRNAs in HCC pathogenesis, and as a possible therapeutic candidate. +circulation_biomarker_diagnosis_up 34826094 hsa-mir-27 Gastroenteritis, Transmissible, of Swine Here, we demonstrated that microRNA-27b-3p (miR-27b-3p) suppressed TGEV replication by directly targeting porcine suppressor of cytokine signaling 6 (SOCS6), while TGEV infection downregulated miR-27b-3p expression in swine testicular (ST) cells and in piglets. Mechanistically, the decrease of miR-27b-3p expression during TGEV infection was mediated by the activated inositol-requiring enzyme 1 (IRE1) pathway of the endoplasmic reticulum (ER) stress. +circulation_biomarker_diagnosis_up 34826094 hsa-mir-27b Gastroenteritis, Transmissible, of Swine Here, we demonstrated that microRNA-27b-3p (miR-27b-3p) suppressed TGEV replication by directly targeting porcine suppressor of cytokine signaling 6 (SOCS6), while TGEV infection downregulated miR-27b-3p expression in swine testicular (ST) cells and in piglets. Mechanistically, the decrease of miR-27b-3p expression during TGEV infection was mediated by the activated inositol-requiring enzyme 1 (IRE1) pathway of the endoplasmic reticulum (ER) stress. +lncRNA target 34826047 hsa-mir-101a Parkinson Disease Our findings demonstrated that lncRNA Riken alleviated the sevoflurane-induced neurotoxic effects, and the lncRNA Riken/miR-101a/MKP-1/JNK axis plays an important role in the cognitive disorder. +genetics_knock down_promote 34826027 hsa-mir-196a Esophageal Squamous Cell Carcinoma Next, functional experiments showed that knockdown of miR-196a or UHRF2 overexpression suppress EC cell proliferation and migration. +genetics_knock down_promote 34825699 hsa-mir-582 Leukemia, Myeloid, Acute CONCLUSION: Knockdown of circ-SFMBT2 suppressed AML progression by regulating the miR +circRNA target 34825467 hsa-mir-636 Uterine Cervical Neoplasms circ_0023404 silencing could attenuate the progression of cervical cancer cells partly by targeting the miR-636/CYP2S1 axis, hinting at a promising therapeutic target for cervical cancer. +other 34825289 hsa-mir-130a Carcinoma, Hepatocellular Here, we found that TFB1M was significantly upregulated in HCC cells probably due to decreased miR-130a-3p expression. +lncRNA target 34825062 hsa-mir-22 Breast Neoplasms We suggest that LIG1 and LIG3 are novel valuable prognostic biomarkers for BC and has-miRNA3p may be a potential therapeutic target for BC. +other 34825000 hsa-mir-199a Cholesteatoma RESULTS: The upregulation of miR-199a was found in cholesteatoma tissues, which facilitated the proliferation, migration, and invasion of HaCaT cells, while its downregulation caused opposite results. +transcription factor target 34824671 hsa-mir-34a Reperfusion Injury, Cerebral Ischemia Mechanistically, neuronal USP29 enhanced p53/miR-34a-mediated silent information regulator 1 downregulation and then promoted the acetylation and suppression of brain and muscle ARNT-like protein, thereby aggravating oxidative stress and apoptosis upon cerebral I/R injury. +genetics_GWAS 34824636 hsa-mir-148 Glioma The objective of the present study was to measure microRNA-3148 (miR-3148) expression and investigate its impact on the pathogenetic mechanism of glioma. +other 34824551 hsa-mir-105 Colorectal Neoplasms lncRNA MCF2L-AS1/miR-105/ IL-1β Axis Regulates Colorectal Cancer Cell Oxaliplatin Resistance. +other 34824224 hsa-mir-122 Hepatitis C For hepatitis C virus (HCV), binding of liver-abundant miR-122 stabilizes the viral RNA and regulates viral translation. +genetics_overexpression_promote 34824176 hsa-mir-155 Uterine Cervical Neoplasms CONCLUSION: Conclusions: These data suggest that overexpression of miRNA-155 can delineate cervical cancer tissues from normal and may be a useful diagnostic biomarker for early detection of cervical cancer. +circulation_biomarker_diagnosis_ns 34823560 hsa-mir-146a Diabetes Mellitus We investigated if serum miR-146a-5p levels were independently associated with micro/macrovascular complications of type 1 diabetes (DM1). CONCLUSIONS: In this large cohort of DM1 patients, we reported an inverse and independent association of miR-146a-5p with diabetes chronic complications and in particular with CVD and retinopathy, suggesting that miR-146a-5p may be a novel candidate biomarker of DM1 complications. +circulation_biomarker_diagnosis_ns 34823560 hsa-mir-146a Diabetes Complications We investigated if serum miR-146a-5p levels were independently associated with micro/macrovascular complications of type 1 diabetes (DM1). CONCLUSIONS: In this large cohort of DM1 patients, we reported an inverse and independent association of miR-146a-5p with diabetes chronic complications and in particular with CVD and retinopathy, suggesting that miR-146a-5p may be a novel candidate biomarker of DM1 complications. +genetics_overexpression_suppress 34823537 hsa-mir-375 Esophageal Squamous Cell Carcinoma miR-375 was found to be significantly down-regulated in esophageal squamous cell carcinoma (ESCC) tissues and its overexpression effectively inhibits the proliferation, migration, and invasion of ESCC cells. +other 34823423 hsa-mir-148b Stomach Neoplasms The expression of miR-148b-3p was negatively correlated with that of UBAP2L in gastric cancer samples. +exosome 34823099 hsa-mir-455 Spinal Cord Ischemia In summary, exosomes containing miR +lncRNA target 34822025 hsa-mir-665 Colorectal Neoplasms Diaphanous Homolog 1 level was regulated by circ_0044556 via sponging miR-665 in CRC cells. +genetics_knock down_promote 34821374 hsa-mir-577 Pancreatic Carcinoma By contrast, miR577 was significantly inhibited in pancreatic cancer cells and tissues; its downregulation promoted pancreatic cancer cell proliferation, migration and invasion, and reversed the effects of FGD5AS1 knockdown on pancreatic cancer cells. In conclusion, in pancreatic cancer, highly expressed FGD5AS1 activated the Wnt/betacatenin signaling and promoted cancer cell proliferation, migration and invasion via suppression of miR577. +genetics_knock down_promote 34821362 hsa-mir-1297 Stomach Neoplasms In a word, lncRNA SNHG6 knockdown had inhibitory effects on DDP resistance and progression of GC by sponging miR-1297, highlighting its potential in GC treatment. +other 34821091 hsa-mir-155 Hyperglycinemia, Nonketotic 3p can promote EAF1 mRNA degradation and proliferation in HANK1 cells. +lncRNA target 34821009 hsa-mir-205 Esophageal Neoplasms Altogether, we highlight that the miR205HG-HNRNPA0 axis is implicated in the migration and invasion of ESCA cells and that these members of this pathway may serve as therapeutic targets to inhibit metastasis of ESCA. +other 34821000 hsa-mir-181a Prostatic Neoplasms We observe that miR-181a is highly expressed in patients with prostate cancer and that this pattern associates with lower expression of NKG2D, a critical mediator of cancer surveillance. +lncRNA target 34820432 hsa-mir-146a Atherosclerosis lncRNA H19 promoted the expression of ANGPTL4 via competitively binding to miR-146a-5p, thus promoting lipid accumulation in atherosclerosis. These findings altogether demonstrated that lncRNA H19 facilitated the accumulation of lipid in macrophages and aggravated the progression of atherosclerosis through the miR-146a-5p/ANGPTL4 pathway. +lncRNA target 34820156 hsa-mir-4268 Aortic Aneurysm, Abdominal CONCLUSIONS: Overall, our data suggest that circRBM33 might be involved in AAA progression by regulating ECM degradation via the miR-4268/EPHB2 axis. +lncRNA target 34820151 hsa-mir-99a Encephalomyelitis, Autoimmune, Experimental MicroRNA-99a (miR-99a) has been shown to be involved in adipose tissue inflammation and to be downregulated in the inflammatory lesions of autoimmune diseases rheumatoid arthritis and systemic lupus erythematosus. Taken together, our results characterize a pivotal role of miR-99a in regulating CD4(+) T cell differentiation and glycolysis reprogramming during EAE development, which may indicate that miR-99a is a promising therapeutic target for the amelioration of multiple sclerosis and possibly other autoimmune diseases. +transcription factor target 34820014 hsa-mir-337 Breast Neoplasms 3p targeted CDK1 to inhibit BC cell progression. +circulation_biomarker_prognosis_up 34820011 hsa-mir-145 Carcinoma, Non-Small-Cell Lung Previous studies have reported the diagnostic and prognostic value of serum microRNA (miR)-145 and vascular endothelial growth factor (VEGF) levels in various types of cancer; however, their clinical use in non-small cell lung cancer (NSCLC) remains unclear. +target gene 34820010 hsa-mir-152 Carcinoma, Non-Small-Cell Lung DNMT3B regulates proliferation of A549 cells through the microRNA-152-3p/NCAM1 pathway. +circulation_biomarker_diagnosis_down 34819824 hsa-mir-126 Coronary Artery Disease CONCLUSION: The results of our study show the potential of circulating miR-126 as a novel non-invasive biomarker in the risk prediction of CAD. +circulation_biomarker_diagnosis_down 34819824 hsa-mir-122 Coronary Artery Disease CONCLUSION: The results of our study show the potential of circulating miR-126 as a novel non-invasive biomarker in the risk prediction of CAD. +transcription factor target 34819106 hsa-mir-6791 Adenocarcinoma of Lung Finally, through analysis of ENST00000609697 target genes, we identified the ENST00000609697-hsa-miR5p-RASL12 ceRNA network, which may play a tumor-suppressive role in LUAD. +lncRNA target 34818977 hsa-mir-874 Osteoporosis In conclusion, miR3p promoted the proliferation and differentiation of hBMSCs by downregulating the expression of LEP, thus inhibiting OP.Abbreviations : miRNAs: microRNAs; OP: osteoporosis; hBMSCs: human Bone Marrow Mesenchymal stem cells; LEP: leptin; DEGs: differentially expressed genes. +lncRNA target 34818974 hsa-mir-140 Adenocarcinoma of Lung 3p inhibited the proliferation, migration, invasion and angiogenesis of LUAD cells via targeting TYMS. +lncRNA target 34818961 hsa-mir-492 Carcinoma, Non-Small-Cell Lung Silencing of miR-492 inhibited NSCLC cell proliferation, migration and invasion, and UTMD-mediated miR-492 inhibitor could promote more significant inhibition, which indicated that UTMD-mediated miR-492 inhibitor might provide a novel strategy for the treatment of NSCLC.KEY MESSAGESmiR-492 inhibitor inhibited cell proliferation, migration and invasion.UTMD-mediated miR-492 inhibitor can promote more significant inhibition.UTMD-mediated miR-492 inhibitor provide a new strategy for NSCLC. +other 34818876 hsa-mir-21 Pre-Eclampsia miR-21 was upregulated in the tissues from PE women, whereas MEG3 was downregulated, and the two were negatively correlated. Collectively, this study demonstrates that the lncRNA MEG3 acts as a sponge for miR-21, which regulates BMPR2 expression and promotes trophoblast cell proliferation and invasiveness, thereby preventing the development of PE. +genetics_knock down_suppress 34818544 hsa-mir-135b Breast Neoplasms In TNBCs, FBXL16 expression is downregulated by the p38/miR-135b-3p axis, and loss of FBXL16 expression restores HIF1alpha-mediated metastatic features of breast cancer. +other 34818353 hsa-mir-181d esophagus adenocarcinoma The expression of hsa-miR-181d, hsa-miR-185, hsa-miR-15b, hsa-miR-214 and hsa-miR-496 was significantly different between normal tissue and EAC. +other 34818353 hsa-mir-185 esophagus adenocarcinoma The expression of hsa-miR-181d, hsa-miR-185, hsa-miR-15b, hsa-miR-214 and hsa-miR-496 was significantly different between normal tissue and EAC. +other 34818353 hsa-mir-15b esophagus adenocarcinoma The expression of hsa-miR-181d, hsa-miR-185, hsa-miR-15b, hsa-miR-214 and hsa-miR-496 was significantly different between normal tissue and EAC. +other 34818353 hsa-mir-214 esophagus adenocarcinoma The expression of hsa-miR-181d, hsa-miR-185, hsa-miR-15b, hsa-miR-214 and hsa-miR-496 was significantly different between normal tissue and EAC. +other 34818353 hsa-mir-496 esophagus adenocarcinoma The expression of hsa-miR-181d, hsa-miR-185, hsa-miR-15b, hsa-miR-214 and hsa-miR-496 was significantly different between normal tissue and EAC. +genetics_overexpression_suppress 34818258 hsa-mir-138 Carcinoma, Ovarian Epithelial 5p-overexpressing ovarian cancer cells successfully recovered the Taxol resistance. +genetics_overexpression_promote 34818249 hsa-mir-196a Acute Kidney Injury lncRNA-H19 overexpression promotes kidney fibrosis and activates fibroblasts during AKI-CKD development, while miR-196a-5p overexpression reversed these effects in vitro. CONCLUSION: lncRNA-H19 induces kidney fibrosis during AKI-CKD by regulating the miR-196a-5p/Wnt/beta-catenin signaling pathway. +genetics_knock down_promote 34818025 hsa-mir-375 Carcinoma, Hepatocellular Replenishing of miR-375 or knockout of NCAPG2 could be therapeutically exploited for HCC. +lncRNA target 34817912 hsa-mir-876 Squamous Cell Carcinoma of Head and Neck CONCLUSION: CircCDR1as acted as an oncogene in OSCC progression through elevating SLC7A11 by targeting miR +genetics_overexpression_promote 34817752 hsa-mir-1277 Glioma 5p overexpression (or ACER3 overexpression) reversed the effects of LINC01087 upregulation (or miR +other 34817483 hsa-mir-214 Aortic Valve Disease Release of AuNP/miRNAs is quantified, AuNP-miR-214 functionality is shown in vitro in HEK293 cells, and AuNP-miRNAs are tracked in a 3D bioprinted human model of calcific aortic valve disease (CAVD). +circulation_biomarker_diagnosis_ns 34817483 hsa-mir-214 autosomal recessive congenital bilateral absence of vas deferens Release of AuNP/miRNAs is quantified, AuNP-miR-214 functionality is shown in vitro in HEK293 cells, and AuNP-miRNAs are tracked in a 3D bioprinted human model of calcific aortic valve disease (CAVD). In the CAVD model, AuNP-miR-214 are tracked into the cytoplasm of human aortic valve interstitial cells. +lncRNA target 34817330 hsa-mir-34c Nasopharyngeal Carcinoma 3p and miR-34c in nasopharyngeal carcinoma tissues and evaluate its clinical value as a molecular marker for predicting the prognosis in patients with nasopharyngeal carcinoma through clinical case study. +lncRNA target 34816790 hsa-mir-101 cervical squamous cell carcinoma 3p suppressed cervical squamous cell carcinoma cell growth by targeting KPNA2. +lncRNA target 34816661 hsa-mir-670 Lung Neoplasms 5p promotes proliferation, migration and invasion of lung cancer cells by targeting WWOX. +transcription factor target 34816499 hsa-mir-195 Sepsis 5p could relieve sepsis-induced MI by targeting ATF6. +transcription factor target 34816499 hsa-mir-195 Cardiomyopathies 5p could relieve sepsis-induced MI by targeting ATF6. +genetics_knock down_promote 34815768 hsa-mir-25 Glioma The knockdown of miR-25 expression significantly reduced glioma cell proliferation, migration and invasion. +target gene 34815714 hsa-mir-181a Stomach Neoplasms Targeting Oncogenic miR-181a-2-3p Inhibits Growth and Suppresses Cisplatin Resistance of Gastric Cancer. +lncRNA target 34815712 hsa-mir-27b Carcinoma, Hepatocellular CONCLUSION: DNAJC3-AS1 promotes HCC by sponging premature miR-27b and might be a biomarker and therapeutic target for HCC. +other 34815668 hsa-mir-452 Emphysema miR-452, miR-149, miR-133a, miR-181a and miR-421 in hub microRNAs may play a role in COPD. +other 34815668 hsa-mir-452 Pulmonary Disease, Chronic Obstructive miR-452, miR-149, miR-133a, miR-181a and miR-421 in hub microRNAs may play a role in COPD. +transcription factor target 34815662 hsa-mir-342 Colonic Neoplasms Objective To explore whether metformin (MET) can affect the biological behaviour and CD133 mRNA expression of CD133+ colon cancer stem cells (CCSCs) through miR +circulation_biomarker_prognosis_ns 34815474 hsa-mir-146a Precursor Cell Lymphoblastic Leukemia-Lymphoma Expression of plasma miR-146a may be utilized as non-invasive marker to diagnose and predict prognosis in pediatric and adult patients with ALL. +other 34815425 hsa-mir-1 Pulmonary Disease, Chronic Obstructive The aim of the study was the assessment of gene expression levels, IL-6, IL-6ST, PIAS3, STAT3, and miRNAs, miRNA-1, miRNA-106b, miRNA-155, in patients with COPD. +other 34815425 hsa-mir-155 Pulmonary Disease, Chronic Obstructive The aim of the study was the assessment of gene expression levels, IL-6, IL-6ST, PIAS3, STAT3, and miRNAs, miRNA-1, miRNA-106b, miRNA-155, in patients with COPD. +other 34815425 hsa-mir-106b Pulmonary Disease, Chronic Obstructive The aim of the study was the assessment of gene expression levels, IL-6, IL-6ST, PIAS3, STAT3, and miRNAs, miRNA-1, miRNA-106b, miRNA-155, in patients with COPD. +genetics_overexpression_promote 34814928 hsa-mir-194 Polycystic Ovary Syndrome METHODS: To clarify the effect of miR-194 in PCOS, CCK-8, Ki67 staining, AO/EB, and flow cytometry assays were used to assess cell growth, proliferation, and apoptosis in KGN cells, which were artificially stimulated to overexpress miR-194. +other 34814394 hsa-mir-483 Non-alcoholic Fatty Liver Disease 3p expression was higher in the NAFLD group (S1 or S2-3) than the control group. +other 34814394 hsa-mir-122 Non-alcoholic Fatty Liver Disease 3p expression was higher in the NAFLD group (S1 or S2-3) than the control group. +other 34814394 hsa-mir-197 Non-alcoholic Fatty Liver Disease 3p expression was higher in the NAFLD group (S1 or S2-3) than the control group. +other 34814394 hsa-mir-146b Non-alcoholic Fatty Liver Disease 3p expression was higher in the NAFLD group (S1 or S2-3) than the control group. +exosome 34814060 hsa-mir-92a Colorectal Neoplasms The detection performance of the PEC biosensor has been tested using colorectal cancer-related exosomal miRNA (miR-92a-3p) as the target. +genetics_knock down_promote 34813772 hsa-mir-375 Glioma Moreover, miR-375 inhibition reverted the anticancer effects of circ-CREBBP knockdown on glioma cells. +circulation_biomarker_diagnosis_ns 34812475 hsa-mir-155 Cardiomegaly Circulating miR155 levels are related to chronic heart failure (CHF). Schisandrin A mediated the AKT/CREB signaling pathway to prevent CHF by regulating the expression of miR155, which may shed light on a possible therapeutic target for CHF. +other 34812409 hsa-mir-335 Parkinson Disease CONCLUSION: miR5p has low expression in PD and is expected to be a potential diagnostic indicator. +circulation_biomarker_diagnosis_ns 34812409 hsa-mir-374a Parkinson Disease The miR-374a-5p expression in the serum of the RG was reduced markedly and had a diagnostic value. +lncRNA target 34812269 hsa-mir-15a Carcinoma, Hepatocellular Our investigation is aimed at testifying the influence of microRNA-15a-5p (miR-15a-5p)/eukaryotic translation initiation factor 4E (eIF4E) on hepatocellular carcinoma resistance to pirarubicin (THP). These findings supported that miR-15a-5p facilitated THP resistance of hepatocellular carcinoma cells by modulating eIF4E, thus providing an experimental basis that miR-15a-5p might act as a novel diagnostic target in hepatocellular carcinoma resistance to THP. +genetics_overexpression_promote 34811815 hsa-mir-924 Carcinoma, Non-Small-Cell Lung miR-924 interacted with the 3' untranslated region (3'UTR) of SLC1A5, and SLC1A5 overexpression largely overturned miR-924 overexpression-mediated anti-tumor effects in NSCLC cells. +genetics_GWAS 34811809 hsa-mir-148a Gastric Cancer, Early METHODS We compared the accuracy of physician-performed endoscopy (trainee, n = 3; specialists, n = 3), artificial intelligence (AI)-based endoscopy, and/or molecular markers (DNA methylation: BARHL2, MINT31, TET1, miR-148a, miR-124a-3, NKX6-1; mutations: TP53; and microsatellite instability) in diagnosing GIN lesions. CONCLUSION AI with miR148s DNA methylation-based diagnosis is a potential modality for diagnosing GIN. +circulation_biomarker_diagnosis_ns 34811713 hsa-mir-574 Schizophrenia 5P, hsa-miR-1827, hsa-miR-4429, CREBRF, ARPP19, TGFBR2, and YWHAZ in blood samples of schizophrenia patients. +circulation_biomarker_diagnosis_ns 34811713 hsa-mir-1827 Schizophrenia 5P, hsa-miR-1827, hsa-miR-4429, CREBRF, ARPP19, TGFBR2, and YWHAZ in blood samples of schizophrenia patients. +circulation_biomarker_diagnosis_ns 34811713 hsa-mir-4429 Schizophrenia 5P, hsa-miR-1827, hsa-miR-4429, CREBRF, ARPP19, TGFBR2, and YWHAZ in blood samples of schizophrenia patients. +exosome 34811696 hsa-mir-128 Carcinoma, Pancreatic Ductal The effect of exosomes rich in hsa-miRNA +lncRNA target 34811354 hsa-mir-150 Thyroid Neoplasms Our findings suggest MIAT may inhibit EZH2 expression and promote PTC cell invasion via the miR-150/EZH2 pathway. +circRNA target 34811353 hsa-mir-200b Urinary Bladder Neoplasms Conclusively, our findings indicate that circKDM4C may act as a pro-oncogenic factor in BCa invasion and metastasis via the circKDM4C/miR-200bc-3p/ZEB1 axis, which is a potential biomarker or therapeutic target for bladder cancer. +target gene 34810290 hsa-mir-21 Stomach Neoplasms Xiaotan Sanjie decoction decoction can inhibit the multiplicative effect of GCIF on gastric cancer cells, growth of gastric tumor and promotion effect of GCIF on tumors, probably due to the down-regulating miR-21 expression in tumor tissues. +other 34809740 hsa-mir-494 Diabetes, Gestational Objective To investigate the relation between the miR-494 expression with pancreatic islets beta cell function and gestational diabetes mellitus. +other 34809738 hsa-mir-136 Leukemia, Myeloid, Acute Methods The expression level of CRNDE in bone marrow cells of AML patients was analyzed by GEPIA database; the mRNA expression levels of miR5p, CRNDE, and minichromosome maintenance 5(MCM5) in AML cell lines were detected by quantitative real-time PCR (qRT-PCR). +circulation_biomarker_diagnosis_ns 34808619 hsa-mir-29b Multiple Sclerosis BACKGROUND: We aimed to evaluate the therapeutic effects of interferon-beta (IFN-beta) on hsa-miR29b-3p and hsa-miR326 in isolated T-helper (Th)1 and Th17 cells expressed by relapsing-remitting multiple sclerosis (RRMS) patients before and after 1 year of treatment with IFN-beta. RESULTS: Th17 cells and plasma levels of IL-17A decreased in RRMS patients after IFN-beta therapy but hsa-miR-29b-3p and hsa-miR-326 expression had no significant change in treated RRMS patients versus baseline. +circulation_biomarker_diagnosis_ns 34808619 hsa-mir-326 Multiple Sclerosis BACKGROUND: We aimed to evaluate the therapeutic effects of interferon-beta (IFN-beta) on hsa-miR29b-3p and hsa-miR326 in isolated T-helper (Th)1 and Th17 cells expressed by relapsing-remitting multiple sclerosis (RRMS) patients before and after 1 year of treatment with IFN-beta. RESULTS: Th17 cells and plasma levels of IL-17A decreased in RRMS patients after IFN-beta therapy but hsa-miR-29b-3p and hsa-miR-326 expression had no significant change in treated RRMS patients versus baseline. +circulation_biomarker_diagnosis_up 34808575 hsa-mir-18a Tuberculosis RESULTS: The expression of GAS5 in TB patients was down-regulated, while miR-18a-5p was up-regulated, and the serum inflammatory factors were negatively correlated with the expression level of GAS5. CONCLUSION: This study indicated that the expression level of GAS5 in the serum of TB patients was decreased, while in the cells infected with MTB, the down-regulated GAS5 might develop a role in facilitating the cell vitality and the inflammatory response by adsorbing miR-18a-5p in the form of molecular sponge. +lncRNA target 34808501 hsa-mir-499a Uterine Cervical Neoplasms Inhibition of DGUOK-AS1, miR-499a-5p, and SPRR1B was applied for exploring the biological function based on detection of cell viability, proliferation, migration, and apoptosis in CESC SiHa and HeLa cells. +transcription factor target 34808462 hsa-mir-376a Glioma miR-376a mimic inhibited SIRT1, YAP1, and VEGF expression and suppressed the proliferation, migration and angiogenesis abilities of the glioma cell lines LN229 and A172, whereas miR-376a inhibitor exerted the opposite functions. +transcription factor target 34808462 hsa-mir-376 Glioma miR-376a mimic inhibited SIRT1, YAP1, and VEGF expression and suppressed the proliferation, migration and angiogenesis abilities of the glioma cell lines LN229 and A172, whereas miR-376a inhibitor exerted the opposite functions. +lncRNA target 34808429 hsa-mir-195 Liver Neoplasms Propofol inhibited the viability of liver cancer cells and stimulated the up-regulation of miR +genetics_knock down_suppress 34808393 hsa-mir-139 Non-alcoholic Fatty Liver Disease NEAT1 knockdown restrained lipid accumulation in the NAFLD cellular model by directly targeting miR +other 34808225 hsa-mir-101 Osteosarcoma 3p. +other 34808131 hsa-mir-1908 Arthritis, Rheumatoid In summary, our study suggests that HOTTIP plays a damaging role in RA by promoting inflammation, which may be related to the regulation of miR5p expression and the STAT3 signaling pathway. +genetics_GWAS 34807526 hsa-mir-19a Leukemia, Myeloid In summary, leukemic cell-derived sEV-related miR-19a-3p confers immunosuppression to CD8+ T cells by targeting SLC6A8-mediated creatine import, indicating that sEV-related miR-19a-3p might be a promising therapeutic target for NPM1-mutated AML. +lncRNA target 34807376 hsa-let-7b Carcinoma, Hepatocellular The current study investigates the inhibitory effect of let-7b miRNA on HCV replication in the Hepatocarcinoma cell line (Huh7.5). +lncRNA target 34807376 hsa-let-7b Hepatitis C The current study investigates the inhibitory effect of let-7b miRNA on HCV replication in the Hepatocarcinoma cell line (Huh7.5). +genetics_GWAS 34806925 hsa-mir-381 Breast Neoplasms More importantly, rescue experiments demonstrated that miR-381 inhibition could inverse the tumor-suppressive effect of SNHG1 silencing in breast cancer. In summary, SNHG1 silencing suppressed tumor progression and overcame breast cancer cell DDP resistance via the epigenetic suppression of miR-381 expression. +other 34806869 hsa-mir-200b Prostatic Neoplasms Using this assay, with a limit-of-detection of 122 aM, we successfully analyzed vesicular miRNA 200b from prostate cancer cell lines and human urine samples, demonstrating the expected lower expression levels of miRNA 200b in the EVs from prostate cancer cells and in the prostate cancer patient's urine samples compared to healthy patients and non-tumorigenic cell lines, validating the suitability of our approach for clinical analysis. +other 34806748 hsa-mir-495 Carcinoma, Hepatocellular 3p and miR-1293 were differentially expressed in HCC patients, and may be involved in the pathophysiology of HCC. +other 34806748 hsa-mir-1293 Carcinoma, Hepatocellular 3p and miR-1293 were differentially expressed in HCC patients, and may be involved in the pathophysiology of HCC. +transcription factor target 34806650 hsa-mir-124 Arthritis, Rheumatoid 3p could specifically promote Th17 cell pathogenicity in part through interaction with T-bet, and these findings present promising therapeutic targets in RA. +genetics_overexpression_promote 34806436 hsa-mir-340 Incisional Pain 5p or overexpression of RAB1A partly reversed the effect of sh-XIST on PIP rats. +circulation_biomarker_prognosis_ns 34806417 hsa-mir-27b Carotid Stenosis The present results provide evidence for circulating miR-27b as a diagnostic and prognostic marker in patients with ACAS. +exosome 34806156 hsa-mir-15b Diabetic Nephropathies In the current study, we determined the role of mesenchymal stem cells (MSCs)-derived extracellular vesicles (EVs) containing microRNA (miR)-15b-5p in DN. +genetics_knock down_promote 34805531 hsa-mir-654 Stomach Neoplasms 5p knockdown on GC cell malignant behaviors. +transcription factor target 34805092 hsa-mir-141 Prostatic Neoplasms Here we chose miRNA141-a potentially diagnostic biomarker of prostate cancer as the model target. +genetics_GWAS 34804964 hsa-mir-146a Precursor Cell Lymphoblastic Leukemia-Lymphoma Conclusion Our findings suggest that SNP located in miR-499a, miR-146a, and miR-196a-2 genes confer risk to ALL in Mexican children. +other 34804964 hsa-mir-499a Leukemia Association Analysis Between the Functional Single Nucleotide Variants in miR-146a, miR-196a-2, miR-499a, and miR-612 With Acute Lymphoblastic Leukemia. +genetics_GWAS 34804964 hsa-mir-146a Leukemia Conclusion Our findings suggest that SNP located in miR-499a, miR-146a, and miR-196a-2 genes confer risk to ALL in Mexican children. +genetics_GWAS 34804964 hsa-mir-196a-2 Precursor Cell Lymphoblastic Leukemia-Lymphoma Conclusion Our findings suggest that SNP located in miR-499a, miR-146a, and miR-196a-2 genes confer risk to ALL in Mexican children. +genetics_GWAS 34804964 hsa-mir-196a-2 Leukemia Conclusion Our findings suggest that SNP located in miR-499a, miR-146a, and miR-196a-2 genes confer risk to ALL in Mexican children. +other 34804964 hsa-mir-612 Leukemia Association Analysis Between the Functional Single Nucleotide Variants in miR-146a, miR-196a-2, miR-499a, and miR-612 With Acute Lymphoblastic Leukemia. +other 34804964 hsa-mir-499a Precursor Cell Lymphoblastic Leukemia-Lymphoma Association Analysis Between the Functional Single Nucleotide Variants in miR-146a, miR-196a-2, miR-499a, and miR-612 With Acute Lymphoblastic Leukemia. +other 34804964 hsa-mir-612 Precursor Cell Lymphoblastic Leukemia-Lymphoma Association Analysis Between the Functional Single Nucleotide Variants in miR-146a, miR-196a-2, miR-499a, and miR-612 With Acute Lymphoblastic Leukemia. +genetics_GWAS 34804952 hsa-mir-499a Endometrial Neoplasms By combining miR-499a-3p or -5p expression levels with the CTNNB1 status, ECs with CTNNB1 mutation and lower miR-499a-5p expression showed better OS compared with the other subgroups (p = 0.03, log-rank test), among the NSMP patients. +other 34804934 hsa-mir-21 Neuroblastoma responsive gene reporter may be a potential method for visualization of the endogenous miR-21 activity in neuroblastoma and its response to gene therapy. +target gene 34804881 hsa-mir-186 Thyroid Cancer, Papillary Long noncoding RNA SNHG6 promotes papillary thyroid cancer cells proliferation via regulating miR-186/CDK6 axis. +other 34804856 hsa-mir-26a Fanconi Anemia The relationship between NEAT1 or fanconi anemia (FA) complementation group E (FANCE) and miR-26a-5p was verified by dual-luciferase reporter assay. +transcription factor target 34804823 hsa-mir-200c Carcinoma, Renal Cell CONCLUSIONS: Our results revealed that downregulation of QKI-5 by miR-200c attenuated KIRC migration and invasion via the EMT process, indicating that QKI-5 may be a potential therapeutic target and a key indicator of KIRC progression. +other 34804425 hsa-mir-146a Diabetic Retinopathy CONCLUSION: It can be concluded that miR-146a-5p may regulate Nrf2 and NF-kappaB expression and inflammation and oxidative stress in the ocular tissue of diabetic rats. +other 34804425 hsa-mir-146a Diabetes Mellitus, Type 2 CONCLUSION: It can be concluded that miR-146a-5p may regulate Nrf2 and NF-kappaB expression and inflammation and oxidative stress in the ocular tissue of diabetic rats. +target gene 34804161 hsa-mir-186 Adenocarcinoma of Lung MiR-186 Suppressed Growth, Migration, and Invasion of Lung Adenocarcinoma Cells via Targeting Dicer1. +circulation_biomarker_diagnosis_up 34804121 hsa-mir-650 Crohn Disease Here, quantitative reverse transcription PCR (RT-QPCR) results revealed that upregulated hsa_circRNA_103124 expression in patients with CD was negatively correlated with hsa-miR-650 expression but positively correlated with the white blood cell count and calprotectin levels. These results indicate that hsa_circRNA_103124 upregulation in patients with CD promotes cell proliferation and inhibits autophagy by regulating the hsa-miR-650/AKT2 signaling pathway. +circulation_biomarker_diagnosis_ns 34804062 hsa-mir-1 Acquired Immunodeficiency Syndrome Here, focusing on a unique cohort of HIV-infected former blood donors, we identified miR-31 (hsa-miR-31) by comparative miRNA profiling as the only miRNA inversely correlating with disease progression. Our results implicated miR-31 as a useful biomarker for tracking HIV disease progression and, by demonstrating its importance in tuning the activation of CD4+ T cells, suggested that miR-31 may play critical roles in other physiological contexts where the CD4+ T cell homeostasis needs to be deliberately controlled. +exosome 34804057 hsa-mir-21 Hyperaldosteronism Association of AGP1 with aldosterone, renin activity, and ARR, besides the high discriminatory capacity of AGP1 and uEV-miR5p to identify the PA condition, place both as potential biomarkers of PA. +other 34804048 hsa-let-7e Tuberculosis, Multidrug-Resistant The miR-let7e-5p is a candidate biomarker for long-term monitoring of treatment for the group of MDR-TB without T2DM. +transcription factor target 34803501 hsa-mir-34a Squamous Cell Carcinoma of Head and Neck Overall, these results suggest that miR-34a-5p can function as a tumor suppressor miRNA in HNSCC owing to its ability to target FLOT-2, highlighting the promise of targeting this regulatory axis to treat HNSCC. +lncRNA target 34803496 hsa-mir-196a Carcinoma, Renal Cell MiR-196a promotes renal cancer cell migration by directly targeting Bram1 and inhibits Smad1/5/8 phosphorylation and MAPK pathways through BMPR1A and EGFR. +other 34803495 hsa-mir-24-2 Retrognathia Conclusions: In this study, we investigated the regulatory mechanism of Mir245p on Gnai3 expression regulation in osteoblast precursor cells and provided a new idea of improving the prevention and treatment strategies for congenital mandibular defects and mandibular protrusion. +circulation_biomarker_diagnosis_down 34803495 hsa-mir-24-2 Mandibular Diseases 5p was significantly downregulated in the serum of young people with overgrowing mandibular, and bioinformatics analysis suggested possible binding sites of Mir24 +other 34803495 hsa-mir-24-2 Bone Diseases Therefore, this study was designed to investigate the mechanism of Mir245p-mediated regulation of Gnai3 gene expression and explore the possibility of potential treatment strategies for bone defects. +other 34803495 hsa-mir-24-2 Temporomandibular Joint Dysfunction Syndrome Conclusions: In this study, we investigated the regulatory mechanism of Mir245p on Gnai3 expression regulation in osteoblast precursor cells and provided a new idea of improving the prevention and treatment strategies for congenital mandibular defects and mandibular protrusion. +other 34803458 hsa-mir-125b Breast Neoplasms Upregulation of miR-125b may be used as a biomarker for the prediction of response to paclitaxel treatment in breast cancer. +lncRNA target 34803403 hsa-mir-552 Esophageal Neoplasms CONCLUSION: Altogether, our findings indicated that LINC00261 exerts a suppressive effect on EC radioresistance via the competing endogenous RNA network to sponge miR +lncRNA target 34803150 hsa-mir-423 Diabetic Nephropathies 5p/GLIPR2 axis might be a potential target for DN treatment. +lncRNA target 34803150 hsa-mir-423 Pulmonary Fibrosis 5p/GLIPR2 axis might be a potential target for DN treatment. +lncRNA target 34803150 hsa-mir-423 Inflammation 5p/GLIPR2 axis might be a potential target for DN treatment. +lncRNA target 34802869 hsa-mir-26b Colorectal Neoplasms Additional algorithms predicted a higher miR-26b level was associated with significantly higher survival in CRC patients and GSK3beta and CDK6 as targets of miR-26b-5p. CONCLUSIONS: Pharmacological intervention with gMG suppressed CRC carcinogenesis and stemness via downregulating GSK3/beta-catenin/CDK6 and upregulating the miR-26b-5p tumor suppressor. +transcription factor target 34802444 hsa-mir-612 Coronary Artery Disease These findings suggest that hypoxic OM-MSC-EVs may represent a promising strategy for ischemic disease by promoting angiogenesis via miR-612 transfer. +other 34802430 hsa-mir-142 Ovarian Neoplasms RESULTS: We showed that miR-25 and miR-142 were differentially expressed between LVSI-positive and LVSI-negative ovarian cancer tumors. +genetics_knock down_promote 34802389 hsa-mir-3681 Glioblastoma 5p overexpression or MALT1 knockdown attenuated aggressiveness of GBM cells. +lncRNA target 34801999 hsa-mir-885 Uterine Cervical Neoplasms 5p in cervical cancer, and the possible targets, as well as the detailed mechanism of miR +other 34801860 hsa-mir-520h Osteosarcoma In this commentary, we have evaluated the work of Peng and colleagues on the identification and function of the signaling axis circ_0088212/miR_520 h/APOA1 in osteosarcoma. +lncRNA target 34801689 hsa-mir-20a Glycogen Storage Disease Type VI Together, these results suggest that equol may have a dual effect on ER-positive cancer cells, acting with, antiproliferative activity through PAPD5 and exhibiting proliferative activity via ERalpha and the former could be associated with miR-320a. +exosome 34801597 hsa-mir-378a Osteolysis Our in vitro and in vivo functional and mechanistic assays revealed that EV-mediated release of miR-378a-3p from tumor cells was upregulated in bone-metastatic PCa, maintaining low intracellular miR-378a-3p concentration to promote proliferation and MAOA-mediated epithelial-to-mesenchymal transition. +lncRNA target 34801596 hsa-mir-409 Carcinoma, Non-Small-Cell Lung Our results suggest that CBR3-AS1 functions as an oncogene through the CBR3-AS1/miR3p/SOD1 pathway, and may represent a new therapeutic target, especially to regulate radiosensitivity in NSCLC. +epigenetics 34801563 hsa-mir-432 Colorectal Neoplasms CONCLUSION: This study showed that DNMT3B induced DNA methylation and downregulation of miR +lncRNA target 34801077 hsa-mir-377 Norrie disease CONCLUSION: CircSMAD4 alleviates HG-induced SV40-MES13 cell inflammation, ECM deposition and apoptosis by relieving miR3p-mediated inhibition on BMP7 in DN progression. +lncRNA target 34800978 hsa-mir-455 Breast Neoplasms CONCLUSION: Hsa_circ_0043278 acts as a tumour suppressor gene in BC through the hsa_circ_0043278/miR +transcription factor target 34800749 hsa-mir-144 Selenium Deficiency In conclusion, Se deficiency can induce apoptosis and cell cycle arrest of bursa of Fabricius in Broilers by up regulating miR3p targeting STC1 and activating PI3K/AKT pathway, leading to injury of bursa of Fabricius in broilers. +other 34800440 hsa-mir-15b Thyroid Cancer, Papillary Among them, six miRNAs (miR-30b-3p, miR-15b-5p, let-7a-5p, miR-130b-3p, miR5p, and miR-193b-3p) were associated with PTC for the first time in the literature, and the expression levels of miR-30b-3p, miR-15b-5p, and let-7a-5p were found to be predictive of disease prognosis. +other 34800440 hsa-let-7a Thyroid Cancer, Papillary Among them, six miRNAs (miR-30b-3p, miR-15b-5p, let-7a-5p, miR-130b-3p, miR5p, and miR-193b-3p) were associated with PTC for the first time in the literature, and the expression levels of miR-30b-3p, miR-15b-5p, and let-7a-5p were found to be predictive of disease prognosis. +other 34800440 hsa-mir-130b Thyroid Cancer, Papillary Among them, six miRNAs (miR-30b-3p, miR-15b-5p, let-7a-5p, miR-130b-3p, miR5p, and miR-193b-3p) were associated with PTC for the first time in the literature, and the expression levels of miR-30b-3p, miR-15b-5p, and let-7a-5p were found to be predictive of disease prognosis. +other 34800440 hsa-mir-424 Thyroid Cancer, Papillary Among them, six miRNAs (miR-30b-3p, miR-15b-5p, let-7a-5p, miR-130b-3p, miR5p, and miR-193b-3p) were associated with PTC for the first time in the literature, and the expression levels of miR-30b-3p, miR-15b-5p, and let-7a-5p were found to be predictive of disease prognosis. +other 34800440 hsa-mir-193b Thyroid Cancer, Papillary Among them, six miRNAs (miR-30b-3p, miR-15b-5p, let-7a-5p, miR-130b-3p, miR5p, and miR-193b-3p) were associated with PTC for the first time in the literature, and the expression levels of miR-30b-3p, miR-15b-5p, and let-7a-5p were found to be predictive of disease prognosis. +circulation_biomarker_diagnosis_up 34800086 hsa-mir-4431 Obesity RESULTS: Serum miR-4431 levels were significantly high in obese and type 2 diabetes mellitus individuals, and positively correlated with the body mass index and fasting plasma glucose levels. +circulation_biomarker_diagnosis_up 34800086 hsa-mir-4431 Diabetes Mellitus, Type 2 RESULTS: Serum miR-4431 levels were significantly high in obese and type 2 diabetes mellitus individuals, and positively correlated with the body mass index and fasting plasma glucose levels. +circulation_biomarker_diagnosis_up 34800057 hsa-mir-210 Squamous Cell Carcinoma of Head and Neck METHODS The expression of EV-miR-210 was measured in the plasma of OSCC patients (n = 30) and compared to that of controls (n = 14). +lncRNA target 34799875 hsa-mir-198 Prostatic Neoplasms In addition, miR-198 directly targeted homeobox A1 (HOXA1), and HOXA1 weakened miR-198 mimic-mediated impacts on PCa cell malignant phenotypes. +genetics_overexpression_promote 34799871 hsa-mir-21 Esophageal Squamous Cell Carcinoma RESULTS: The population of IL-10 and TGF-beta-producing CTLs (CD8+ Tregs) were considerably expanded, in addition to the overexpression of miR-21 in both groups (ND and UT) of ESCC patients, while the frequency of Tc17 and CD8+ Treg cells increased only in UT patients. +genetics_overexpression_promote 34799871 hsa-mir-21 Esophageal Neoplasms RESULTS: The population of IL-10 and TGF-beta-producing CTLs (CD8+ Tregs) were considerably expanded, in addition to the overexpression of miR-21 in both groups (ND and UT) of ESCC patients, while the frequency of Tc17 and CD8+ Treg cells increased only in UT patients. +genetics_GWAS 34799795 hsa-mir-19b Glioma In conclusion, by studying the changes in the key parameters of glioma patients who were subjected to radiotherapy, we concluded that the rs7853346 polymorphism in lncRNA-PTENP1 and the rs1799864 polymorphism in CCR2 could independently affect cognitive impairment, while a more significant combined effect on cognitive impairment was exerted in glioma patients via the signaling pathway of PTENP1/miR-19b/CCR2. +genetics_overexpression_promote 34799723 hsa-mir-519d Prostatic Neoplasms Overexpression of miR-519d-3p led to inhibited PCa cell proliferation, invasion and migration, and p53 overexpression was found to promote miR-519d-3p expression to suppress the malignant characteristics of PCa cells, while the additional E2F1 overexpression restored the malignant traits. +genetics_GWAS 34799665 hsa-mir-191 Infant, Low Birth Weight 3p was reliably different in individuals with LBW, and could be a new player in the epigenetic mechanisms connecting LBW and future endocrine-metabolic adverse outcomes. +genetics_knock down_promote 34798882 hsa-mir-149 Ovarian Neoplasms 3p overexpression in cisplatin-resistant OC cells led to contrary results. +other 34798868 hsa-mir-128a Glioblastoma 3p and 17-5p for most of the cells. +other 34798868 hsa-mir-221 Glioblastoma 3p and 17-5p for most of the cells. +other 34798868 hsa-mir-34 Glioblastoma 3p and 17-5p for most of the cells. +lncRNA target 34798192 hsa-mir-146a Zika Virus Infection ZIKV-NS1 induced the expression of miR-146a and suppressed the ROS activity in human microglial cells. +genetics_overexpression_promote 34797887 hsa-mir-21 Breast Neoplasms 3p overexpression in breast tumors is a marker of worse breast cancer progression and it affects genes in pathways that drive breast cancer by down-regulating tumor suppressor genes. +transcription factor target 34797837 hsa-mir-3163 Triple Negative Breast Neoplasms The results of current study suggest that CCNB1 and hsa-miR-3163 may serve as highly potential prognostic markers and therapeutic targets for AR positive TNBC. +other 34797582 hsa-mir-31 salivary gland adenoid cystic carcinoma 3p could be an independent prognostic factor for salivary adenoid cystic carcinoma. +transcription factor target 34797485 hsa-mir-1224 Cerebrovascular Disorders This study aimed to investigate the function of miR-1224 in OGD/R-induced hippocampal neuron apoptosis, as well as the regulatory mechanism of miR-1224 in ischemic cerebrovascular disease. Our findings indicated that miR-1224 downregulation suppressed OGD/R-induced hippocampal neuron apoptosis by targeting Ku protein, suggesting that miR-1224 could serve as a new target for ischemic cerebrovascular disease treatment. +genetics_knock down_suppress 34797473 hsa-mir-491 Atherosclerosis Circ_0003204 knockdown protects HUVECs against ox-LDL-induced injuries by targeting the miR5p-ICAM1 pathway, hinting that circ_0003204 inhibition might prevent AS development. +other 34797326 hsa-mir-155 Tuberculosis Notably, the accuracy and efficacy of miRNA-155 in pediatric TB were higher than those in adult TB. CONCLUSION: The results of the meta-analysis suggested that miRNA-155 could serve as an effective biomarker for identifying active TB. +circulation_biomarker_prognosis_ns 34797300 hsa-mir-423 Heart Failure In conclusion, the meta-analysis results suggest that HF patients with low expression of serum miR-1, miR +circulation_biomarker_prognosis_ns 34797300 hsa-mir-18b Heart Failure In conclusion, the meta-analysis results suggest that HF patients with low expression of serum miR-1, miR +circulation_biomarker_prognosis_ns 34797300 hsa-mir-18a Heart Failure In conclusion, the meta-analysis results suggest that HF patients with low expression of serum miR-1, miR +other 34797299 hsa-mir-23a Pulmonary Disease, Chronic Obstructive 5p, and miR-23a-5p might participate in the nosogenesis of COPD. +other 34797299 hsa-mir-194 Pulmonary Disease, Chronic Obstructive 5p, and miR-23a-5p might participate in the nosogenesis of COPD. +lncRNA target 34796909 hsa-mir-146a Osteoarthritis The present study revealed the protective effects of the FAM201A/miR146a5p/POU2F1 positive feedback loop on IL1betainduced chondrocyte injury and provided a potential therapeutic target for OA. +circRNA target 34796777 hsa-mir-1299 Lung Neoplasms Furthermore, PDL1 was a functional target of miR-1299, and miR-1299 inhibited lung cancer cell development via decreasing PDL1 expression. +circulation_biomarker_diagnosis_up 34796469 hsa-mir-222 Pre-Eclampsia 3p inhibited HDAC6 expression and blocked the Notch1 signaling, thus suppressing trophoblast cell proliferation and migration and attenuating blood pressure and fetal detrimental changes in PE rats, which is expected to become a therapeutic target for PE. +other 34796453 hsa-mir-21 Stroke Overall, the results of this study implicate miR-21 as a promising candidate for therapeutic translation after stroke. +lncRNA target 34796452 hsa-mir-3163 Nasopharyngeal Carcinoma Overall, our data highlighted that CRNDE could promote NPC progression via altering miR-3163/TWIST1 axis, suggesting CRNDE as a potential prognostic biomarker and therapeutic target for NPC treatment. +other 34796409 hsa-mir-101 Osteoarthritis 3p were assessed as core miRNAs using overlapping analyses. +other 34796409 hsa-mir-451a Osteoarthritis 3p were assessed as core miRNAs using overlapping analyses. +other 34796409 hsa-mir-210 Osteoarthritis 3p were assessed as core miRNAs using overlapping analyses. +other 34796409 hsa-mir-370 Osteoarthritis 3p were assessed as core miRNAs using overlapping analyses. +lncRNA target 34796378 hsa-mir-98 Polycystic Ovary Syndrome 3p targets and downregulates YY1 expression, thereby affecting the proliferation and apoptosis of OGCs in PCOS. +genetics_overexpression_promote 34796112 hsa-mir-200a Glioma Moreover, overexpression of miR-200a resulted in down-regulation of ZEB1 and further inhibited malignant phenotype of glioma cells. +genetics_overexpression_promote 34796092 hsa-mir-19a Colorectal Neoplasms Silencing of STAT3 reduced the hypoxia-induced activity of CRC cells, whereas the malignant behaviors of cells were restored after miR-19a upregulation but blocked after PTEN overexpression. This study demonstrated that hypoxia augments activity and malignant behaviors of colorectal cancer cells through the STAT3/miR-19a/PTEN/PI3K/AKT axis. +other 34795923 hsa-mir-1 Mesothelioma, Malignant, Pleural The two-biomarker score is useful to identify a subgroup of e-MPM tumors characterized by BAP1 retained and high miR-31 levels with worse clinical outcome. +genetics_knock down_suppress 34795259 hsa-mir-1307 Pancreatic Carcinoma Chemotherapy-induced apoptosis and DNA damage accumulation are higher in MIR1307 knock-out (MIR1307KO) versus control PDAC cells, while re-expression of MIR1307 in MIR1307KO cells rescues these effects. +genetics_overexpression_promote 34794217 hsa-mir-369 Carcinoma, Hepatocellular 3p+ pcDNA group, overexpression of ACTN4 increased the proliferation ability of hepatocellular carcinoma MHCC97H cells at 72 hours of culture[(1.12+/-0.11) vs (0.68+/-0.06), P<0.001], significantly reduced the proportion of cells in G(1) stage [(38.81+/-3.24)% vs (51.80+/-4.57)%, P<0.001], significantly increased the proportion of S-phase cells [(31.65+/-3.11)% vs (15.69+/-1.44)%, P<0.001], decreased cell apoptosis rate [(13.86+/-1.37)% vs (22.69+/-2.24)%, P<0.001], increased protein expressions of cyclin D1 and Bcl-2 (P<0.001), decreased the protein expressions of p21 and Bax (P<0.001). +other 34794216 hsa-mir-3666 Carcinoma, Hepatocellular Pearson correlation was used to analyze the correlation between LINC00839 and miR-3666 expression in liver cancer tissues. The expression levels of LINC00839 and miR-3666 in liver cancer tissue were negatively correlated (r=-0.658, P<0.001). +lncRNA target 34793941 hsa-mir-342 Inflammation-Related Depression Here, we studied how peripubertal stress (PPS) combined with differential corticosterone (CORT)-stress responsiveness (CSR) influences depressive-like behaviors and brain inflammatory markers in male rats in adulthood, and how these alterations relate to microglia activation and miR-342 expression. Our work highlights miR-342 as a potential therapeutic target in inflammation-related depression. +genetics_knock down_promote 34793775 hsa-mir-30 Uterine Cervical Neoplasms 5p inhibition or MARK2 overexpression could countervail the suppressive effect of ABHD11-AS1 knockdown on CC cell malignant behaviors. +lncRNA target 34793694 hsa-mir-124 Huntington Disease Proteomic analyses of the growth cones revealed that NUMA1 (nuclear/mitotic apparatus protein 1) is downregulated in HD by miR-124. Suppressing NUMA1 in wild-type cells recapitulates the microtubule and axonal growth defects of HD, whereas raising NUMA1 levels with antagomiR-124 or stabilizing microtubules with epothilone B restores microtubule organization and rescues axonal growth. +transcription factor target 34793551 hsa-mir-5195 Duane Retraction Syndrome In summary, miR3p targeting GMFB might be a potential therapeutic target for DR. +genetics_overexpression_promote 34793477 hsa-mir-197 Carcinoma, Hepatocellular 3p was poorly expressed in HCC, while AGR2 was overexpressed. +other 34793290 hsa-mir-106b Breast Neoplasms 3p, -193a-5p, and -10b-5p could detect early-stages of BC with 0.79 sensitivity, 0.86 specificity and 0.82 accuracy. +other 34793290 hsa-mir-106b Breast Diseases 3p, -193a-5p, and -10b-5p could detect early-stages of BC with 0.79 sensitivity, 0.86 specificity and 0.82 accuracy. +genetics_knock down_promote 34793263 hsa-mir-582 Ovarian Neoplasms 3p promoted the proliferation and migration of OC cells, while overexpression inhibited them. +exosome 34792792 hsa-mir-1205 Colorectal Neoplasms Exosomal transfer of circ_0006174 contributes to the chemoresistance of doxorubicin in colorectal cancer by depending on the miR-1205/CCND2 axis. Altogether, these findings unraveled that circ_0006174-enriched exosomes elevated DOX chemoresistance in CRC by the miR-1205/CCND2 axis. +other 34792755 hsa-mir-146a Fanconi Anemia The decrease in miR-146a-5p was also validated using RT-qPCR and emerged as a strong candidate as a modulator of BM mRNAs in FA patients. +other 34792704 hsa-mir-486 Liposarcoma, Myxoid Collectively, our observations clearly suggested that FUS-CHOP regulated myxoid liposarcoma cell proliferation and apoptosis by the regulation of miR-486/CDK4 axis, indicating the potential use of FUS-CHOP-siRNA as a promising therapy for myxoid liposarcoma. +other 34792645 hsa-mir-425 Esophageal Squamous Cell Carcinoma 3p, PIK3CD and CFL1 were associated with lipid regulation, cell proliferation and differentiation, so the two ceRNAs regulatory networks may play an important role in regulating intramuscular fat (IMF) deposition, thereby affecting pork quality. +genetics_knock down_promote 34792404 hsa-mir-16 Cardiomyopathies Additionally, miRNA5p knockdown and miRNA-26a-5p overexpression significantly promoted cardiomyocyte hypertrophy in neonatal rat cardiomyocytes. +genetics_knock down_promote 34792404 hsa-mir-26a Cardiomyopathies Additionally, miRNA5p knockdown and miRNA-26a-5p overexpression significantly promoted cardiomyocyte hypertrophy in neonatal rat cardiomyocytes. +other 34791555 hsa-mir-127 Breast Neoplasms The ROC analysis was used to optimize a set of markers for diagnosing breast cancer at the early stages consisting of 4 microRNA genes: MIR125B1, MIR127, MIR1258, and MIR132; the system is characterized by 100% specificity, 85% sensitivity, and AUC=0.924. +other 34791555 hsa-mir-132 Breast Neoplasms The ROC analysis was used to optimize a set of markers for diagnosing breast cancer at the early stages consisting of 4 microRNA genes: MIR125B1, MIR127, MIR1258, and MIR132; the system is characterized by 100% specificity, 85% sensitivity, and AUC=0.924. +other 34791555 hsa-mir-125b-1 Breast Neoplasms The ROC analysis was used to optimize a set of markers for diagnosing breast cancer at the early stages consisting of 4 microRNA genes: MIR125B1, MIR127, MIR1258, and MIR132; the system is characterized by 100% specificity, 85% sensitivity, and AUC=0.924. +other 34791555 hsa-mir-1258 Breast Neoplasms The ROC analysis was used to optimize a set of markers for diagnosing breast cancer at the early stages consisting of 4 microRNA genes: MIR125B1, MIR127, MIR1258, and MIR132; the system is characterized by 100% specificity, 85% sensitivity, and AUC=0.924. +other 34791478 hsa-mir-16 Stomach Neoplasms In this research, changes in the expression of B-cell lymphoma 2 (BCL2), miRb and miR-16 in human adenocarcinoma gastric cancer cell line (AGS) following the exposure to magnetic flux densities (MFDs) of 0.2 and 2 mT continuously and discontinuously (1.5 h on/1.5 h off) for 18 h were investigated. +other 34791478 hsa-mir-15b Stomach Neoplasms In this research, changes in the expression of B-cell lymphoma 2 (BCL2), miRb and miR-16 in human adenocarcinoma gastric cancer cell line (AGS) following the exposure to magnetic flux densities (MFDs) of 0.2 and 2 mT continuously and discontinuously (1.5 h on/1.5 h off) for 18 h were investigated. +other 34791059 hsa-mir-744 Ovarian Neoplasms Moreover, mechanism analysis unveiled that NRSN2-AS1 functioned as a miR5p sponge to regulate PRKX expression in OV cells. +genetics_knock down_suppress 34790800 hsa-mir-139 Neurotic Disorders 5p gain- and loss-of-function on depression-like behaviors, the expression level of PDE4D, and hippocampus neurogenesis. +other 34790800 hsa-mir-139 Colorectal Neoplasms Elisa, western blotting, and fluorescence in situ hybridization (FISH) were used to detect the expression of miR5p and PDE4D in CRC tissues. +other 34790783 hsa-mir-335 Esophageal Squamous Cell Carcinoma COL11A1 promotes esophageal squamous cell carcinoma proliferation and metastasis and is inversely regulated by miR-335-5p. +lncRNA target 34790777 hsa-mir-181d Kidney Diseases Finally, we evaluated the effects of circRNA_0045861 target gene miR-181d-5p on UPJO-induced renal fibrosis in vivo. CONCLUSIONS: Circ_0045861 may be a novel candidate circRNA in the pathogenesis of UPJO by acting as a pro-apoptotic factor via the miR-181d-5p/SIRT1 axis. +lncRNA target 34790777 hsa-mir-181d ureteropelvic junction obstruction Finally, we evaluated the effects of circRNA_0045861 target gene miR-181d-5p on UPJO-induced renal fibrosis in vivo. CONCLUSIONS: Circ_0045861 may be a novel candidate circRNA in the pathogenesis of UPJO by acting as a pro-apoptotic factor via the miR-181d-5p/SIRT1 axis. +other 34790764 hsa-mir-16 Atherosclerosis Our in vivo experiments also demonstrated that artesunate reduced lipid accumulation, atherosclerotic plaque formation, and antagonized inflammation in a dose-dependent manner by upregulating miR5p. +other 34790744 hsa-mir-744 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: In summary, our results confirmed for the first time the regulatory mechanism of CDX2 on miR-744 transcription and provided a potential mechanism for CDX2 as an oncogene in lung cancer. +lncRNA target 34790743 hsa-mir-34c Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: MiR-34c-5p regulates the proliferation, migration, invasion, and apoptosis of OSCC through targeted binding of TRIM29. +lncRNA target 34790726 hsa-mir-34a Fibrosis Moreover, miR-34a activates HSCs through transforming TGF-beta, alpha-smooth muscle actin (alpha-SMA), and Monocyte chemoattractant protein-1 (MCP-1), which further affects liver fibrosis. +other 34790674 hsa-mir-593 Uterine Cervical Neoplasms 5p, and mir-15b-5p) were found to regulate two key metabolic enzymes, EZH2 and AKR1C2, with altered metabolites (L-lysine and tetrahydrodeoxycorticosterone, THDOC) status in cervical cancer. +other 34790674 hsa-mir-16 Uterine Cervical Neoplasms 5p, and mir-15b-5p) were found to regulate two key metabolic enzymes, EZH2 and AKR1C2, with altered metabolites (L-lysine and tetrahydrodeoxycorticosterone, THDOC) status in cervical cancer. +other 34790674 hsa-mir-147a Uterine Cervical Neoplasms 5p, and mir-15b-5p) were found to regulate two key metabolic enzymes, EZH2 and AKR1C2, with altered metabolites (L-lysine and tetrahydrodeoxycorticosterone, THDOC) status in cervical cancer. +other 34790674 hsa-mir-15b Uterine Cervical Neoplasms 5p, and mir-15b-5p) were found to regulate two key metabolic enzymes, EZH2 and AKR1C2, with altered metabolites (L-lysine and tetrahydrodeoxycorticosterone, THDOC) status in cervical cancer. +other 34790674 hsa-mir-138 Uterine Cervical Neoplasms 5p, and mir-15b-5p) were found to regulate two key metabolic enzymes, EZH2 and AKR1C2, with altered metabolites (L-lysine and tetrahydrodeoxycorticosterone, THDOC) status in cervical cancer. +lncRNA target 34790580 hsa-mir-7 Colorectal Neoplasms Restoration of HOXD10 activates the expressions of miR-7 and IGFBP3 and results in an inhibited phenotype biologically, suggesting its potential therapeutic relevance in colorectal cancer (CRC). +circulation_biomarker_diagnosis_down 34790566 hsa-mir-146a Carcinoma, Non-Small-Cell Lung Conclusions The current data suggest that the miR-146a expression in PBMC and serum TGF- and IL-1 levels may act as blood markers in NSCLC patients. +lncRNA target 34790379 hsa-mir-183 Stomach Neoplasms 5p participates in the tumorigenesis and development of GC via certain signaling pathways, in particular the nerve- and immunity-related genes. +target gene 34790377 hsa-mir-206 Esophageal Neoplasms Long non-coding RNA HAGLROS regulates the proliferation, migration, and apoptosis of esophageal cancer cells via the HAGLROS-miR-206-NOTCH3 axis. +target gene 34790374 hsa-mir-873 Stomach Neoplasms MiR-873-5p targets THUMPD1 to inhibit gastric cancer cell behavior and chemoresistance. +lncRNA target 34790286 hsa-mir-574 Stroke CONCLUSION: circPHKA2 could protect HBMEC against OGD-induced cerebral stroke model via the miR5p/SOD2 axis, suggesting circPHKA2 as a novel and promising candidate in ischemic brain injury. +lncRNA target 34790286 hsa-mir-574 Hypoxia-Ischemia, Brain CONCLUSION: circPHKA2 could protect HBMEC against OGD-induced cerebral stroke model via the miR5p/SOD2 axis, suggesting circPHKA2 as a novel and promising candidate in ischemic brain injury. +circulation_biomarker_diagnosis_ns 34790240 hsa-mir-133 Thrombocytopenia The proportion of Bregs and the IL-10 secretion could be further promoted by the UC-MSCs treated with 0.1 mug/mL SDF-1alpha, which could also promote the miRNA-133 expression of UC-MSCs in an exosome-dependent manner; moreover, while the UC-MSCs were transfected with the miR-133 inhibitor, the proportion of induced Bregs decreased obviously when cocultured with peripheral blood mononuclear cells (PBMCs) of ITP. We conclude that UC-MSCs could effectively enhance the decreased proportion of Bregs from ITP; at appropriate concentrations, SDF-1alpha may promote the proliferating and survival ability of UC-MSCs and improve the production of Bregs induced by UC-MSCs through controlling miRNA-133 expression in the exosomes. +other 34790229 hsa-mir-16 Diabetic Nephropathies 5p-ATF3 might be potential RNA regulatory pathways to regulate the disease progression of early DN. +other 34790229 hsa-mir-27a Diabetic Nephropathies 5p-ATF3 might be potential RNA regulatory pathways to regulate the disease progression of early DN. +other 34790229 hsa-let-7b Diabetic Nephropathies 5p-ATF3 might be potential RNA regulatory pathways to regulate the disease progression of early DN. +other 34790229 hsa-mir-93 Diabetic Nephropathies 5p-ATF3 might be potential RNA regulatory pathways to regulate the disease progression of early DN. +lncRNA target 34790052 hsa-mir-93 Small Cell Lung Carcinoma 5p, which may be potential targets for SCLC patients. +other 34789642 hsa-mir-143 Aortic Aneurysm, Abdominal Direct relationship miR3p and circ-FNDC3B or ADAM10 was verified by dual-luciferase reporter and RNA immunoprecipitation assays.Circ-FNDC3B was highly expressed in AAA tissues and Ang-II-treated VSMCs. +other 34789323 hsa-mir-28 Fetal Growth Retardation miR5p was reduced in FGR pregnancies (p < 0.01) only when there was a female offspring and miR-301a-3p was only reduced in FGR pregnancies with a male fetus (p < 0.05). +genetics_knock down_suppress 34789312 hsa-mir-497 Endometrial Neoplasms 5p or increase in FASN could neutralize the modulatory actions of SNHG25 knockdown in EC cells. +lncRNA target 34789310 hsa-mir-129 Ovarian Neoplasms, High-Grade Serous 3p repressed SOC cell processes via binding to MAP3K3. +other 34789303 hsa-mir-544 Ovarian Neoplasms miR5p expression was decreased, while SOX12 expression was increased in OC tumor tissues and cells. +lncRNA target 34789303 hsa-mir-744 Ovarian Neoplasms CONCLUSION: MNX1-AS1 promoted the development of OC through miR5p/SOX12 axis. +lncRNA target 34789275 hsa-mir-20a Non-alcoholic Fatty Liver Disease CircRNA_0001805 targeted miR-106a-5p/miR-320a, which served as an upstream inhibitor of ABCA1/CPT1 and collaboratively regulated NAFLD progression. +lncRNA target 34789275 hsa-mir-106a Non-alcoholic Fatty Liver Disease CircRNA_0001805 targeted miR-106a-5p/miR-320a, which served as an upstream inhibitor of ABCA1/CPT1 and collaboratively regulated NAFLD progression. +target gene 34789263 hsa-mir-365a Breast Neoplasms The inhibition of circular RNA circNOLC1 by propofol/STAT3 attenuates breast cancer stem cells function via miR-365a-3p/STAT3 signaling. +other 34789260 hsa-mir-217 Gallbladder Neoplasms CONCLUSIONS: Our findings demonstrated that circTP63 sponged to miR-217 and regulated EZH2 expression and finally facilitated tumor progression in GBC. +genetics_overexpression_suppress 34789086 hsa-mir-204 Leukemia, Myeloid, Acute HGF overexpression reversed the effects of miR-204 mimic on AML cell proliferation, apoptosis, migration, and invasion. +genetics_GWAS 34788764 hsa-mir-142 Femur Head Necrosis CONCLUSION: Our results first confirm that the genetic polymorphism of MIR3142HG is associated with steroid-induced ONFH susceptibility in Chinese Han population. +circulation_biomarker_prognosis_ns 34788749 hsa-mir-122 Liver Neoplasms CONCLUSIONS: Longitudinal examination of serial liver biopsies indicated that the circulating miR-122 dynamics might be useful in predicting the prognosis for NAFLD patients with severe fibrosis stage and no improvement of the stage scores. +circulation_biomarker_prognosis_ns 34788749 hsa-mir-122 Non-alcoholic Fatty Liver Disease CONCLUSIONS: Longitudinal examination of serial liver biopsies indicated that the circulating miR-122 dynamics might be useful in predicting the prognosis for NAFLD patients with severe fibrosis stage and no improvement of the stage scores. +circulation_biomarker_diagnosis_down 34788141 hsa-mir-106b Multiple Sclerosis Materials and Methods: Serum levels of BDNF and peripheral blood mononuclear cell (PBMC) expression levels of miR +circulation_biomarker_diagnosis_down 34788141 hsa-mir-132 Multiple Sclerosis Materials and Methods: Serum levels of BDNF and peripheral blood mononuclear cell (PBMC) expression levels of miR +circulation_biomarker_diagnosis_down 34788141 hsa-mir-19b Multiple Sclerosis Materials and Methods: Serum levels of BDNF and peripheral blood mononuclear cell (PBMC) expression levels of miR +other 34787848 hsa-mir-1827 Breast Neoplasms By negatively regulating miR-1827 level, LINC00174 aggravates the malignant development of BCa. +transcription factor target 34787641 hsa-mir-181a Diabetes Mellitus, Type 2 Furthermore, we revealed that Rik may positively impact diabetic corneal epithelial wound healing by sponging miR-181a-5p, providing a novel potential therapeutic target of diabetic keratopathy (DK). +genetics_knock down_promote 34787343 hsa-mir-886 Prostatic Neoplasms The knockdown of miR-886 inhibits cellular processes of prostate cancer, which provides a novel therapeutic target. +lncRNA target 34787069 hsa-mir-199a Epilepsy, Temporal Lobe LncRNA TUG1 may be a biomarker of TLE diagnosis in children, and can regulate hippocampal neuron cell activity and apoptosis via sponging miR-199a-3p. +other 34787068 hsa-mir-1 Thromboangiitis Obliterans 3p/GNA12 signaling as a novel mechanism for TAO progression. +lncRNA target 34787066 hsa-mir-1296 Breast Neoplasms Collectively, it is concluded that circ_0048764 promotes the development of BC via modulating the miR +genetics_knock down_promote 34787058 hsa-mir-107 Wilms Tumor In addition, circSLC7A6 knockdown inhibited WT progression, while the effect was partially abolished by the downregulation of miR-107. In conclusion, the present study demonstrated that circSLC7A6 facilitated WT progression by upregulating ABL2 through inhibiting miR-107 expression. +lncRNA target 34787053 hsa-mir-28 Chromate Resistance To sum up, our findings, for the first time, demonstrated that DEX exerted neuroprotective effects on hippocampal neurons against H/R treatment via the circ-CDR1as/miR3p/TRAF3 regulatory network, providing novel therapeutic targets for DEX administration in CI/R treatment. +lncRNA target 34787053 hsa-mir-28 Osteoarthropathy, Primary Hypertrophic To sum up, our findings, for the first time, demonstrated that DEX exerted neuroprotective effects on hippocampal neurons against H/R treatment via the circ-CDR1as/miR3p/TRAF3 regulatory network, providing novel therapeutic targets for DEX administration in CI/R treatment. +genetics_overexpression_suppress 34787051 hsa-mir-543 Breast Neoplasms Furthermore, miR-543 overexpression undermined the UBE2T promotional effect by inhibiting ERK/MAPK pathway activity in breast cancer cells. +other 34787047 hsa-mir-103a Triple Negative Breast Neoplasms Collectively, PCAT18 was expressed at low levels in TNBC, and PCAT18 could sponge miR-103a-3p and promote ATF7 expression, resulting in prevention of TNBC metastasis. +genetics_overexpression_promote 34786378 hsa-mir-532 Carcinoma, Hepatocellular 5p overexpression on HCC cell proliferation, migration and invasion. +target gene 34786212 hsa-mir-204 Breast Neoplasms DGUOK-AS1 acts as a tumorpromoter through regulatingmiR-204-5p/IL-11 axis in breast cancer. +circulation_biomarker_diagnosis_up 34786210 hsa-mir-188 Carcinoma, Hepatocellular Endoplasmic reticulum stress promotes sorafenib resistance via miR-188-5p/hnRNPA2B1-mediated upregulation of PKM2 in hepatocellular carcinoma. +lncRNA target 34786209 hsa-mir-199a Cardiomegaly This study suggests a possible new strategy for cardiac remodeling therapy by inhibiting miR-199a-5p and -3p. +lncRNA target 34786209 hsa-mir-199a Diabetic Nephropathies This study suggests a possible new strategy for cardiac remodeling therapy by inhibiting miR-199a-5p and -3p. +lncRNA target 34786084 hsa-mir-378b Hypoxia-Ischemia, Brain Overall, the present findings suggest that ANRIL exerts its protective effects via binding to miR-378b and upregulating ATG3 expression, suggesting the potential of ANRIL as a protective target for HIBD. +circulation_biomarker_prognosis_up 34786079 hsa-mir-506 Liver Neoplasms Cox proportional hazards regression model analysis revealed that TNM staging and low serum miR +transcription factor target 34786071 hsa-mir-21 Sepsis 5p, and both molecules serve as potential therapeutic targets for heart sepsis patients. +target gene 34786067 hsa-mir-429 Triple Negative Breast Neoplasms ln RNA LINC01234 promotes triple-negative breast cancer progression through regulating the miR-429/SYNJ1 axis. +lncRNA target 34786066 hsa-mir-22 Pneumonia Also, LncRNA H19 acts as a sponge of miR3p, which targets NLRP3, and NLRP3 attenuates the effect of LncRNA H19 silencing on LPS-induced WL-38 cell pyroptosis. +genetics_overexpression_promote 34786062 hsa-mir-486 Asthma, Allergic Overexpression of miR +lncRNA target 34786060 hsa-mir-146a Diabetes Mellitus, Type 2 OBJECTIVE: To investigate the effect of long non-coding RNA (LncRNA) PTGS2 on islet beta-cell function via the miR-146a-5p/Retinol binding protein 4 (RBP4) axis and its diagnostic value in type 2 diabetes mellitus (T2DM). +circulation_biomarker_prognosis_up 34786057 hsa-mir-18a Vascular Malformations Thus, we identified a prognostic serum miR-18a-5p and validated its function in VM. +target gene 34786052 hsa-mir-21 Colorectal Neoplasms m(6)A demethylase ALKBH5 inhibits cell proliferation and the metastasis of colorectal cancer by regulating the FOXO3/miR-21/SPRY2 axis. +other 34786048 hsa-mir-144 Colorectal Neoplasms LncRNA SNHG4 promotes malignant biological behaviors and immune escape of colorectal cancer cells by regulating the miR-144-3p/MET axis. +lncRNA target 34786045 hsa-mir-4731 Breast Neoplasms 5p to modulate BC progression through FOXM1. +circulation_biomarker_diagnosis_up 34786043 hsa-mir-214 Tibial Fractures 3p, and it is related to promoting the osteoblast proliferation, inhibiting apoptosis, and up-regulating the serum ALP and OPG levels to accelerate bone healing. +other 34786024 hsa-mir-146a ST Elevation Myocardial Infarction STEMI patients with high levels of miR-146a had a higher risk of major adverse cardiovascular events (MACEs) than those with low levels of miR-146a (log-rank P = 0.034). CONCLUSION: The incidence of MACEs in STEMI patients expressing high levels of miR-146a was significantly greater than in those expressing low levels. +target gene 34785951 hsa-mir-198 Breast Neoplasms A Novel Circular RNA circPTCD3 Promotes Breast Cancer Progression Through Sponging miR-198. +lncRNA target 34785791 hsa-mir-15a Histiocytosis Our findings suggest that miR-15a-5p is a tumor suppressor in ECD through the CXCL10-ERK-LIN28a-let7 axis, highlighting another layer of post-transcriptional regulation in this disease. +genetics_overexpression_promote 34785625 hsa-mir-296 Triple Negative Breast Neoplasms Moreover, overexpression of SOX4 or activation of Wnt pathway rescued the miR +other 34785595 hsa-mir-106b Epilepsy These results unmask a regulatory mechanism of KCNQ2 channel expression in early postnatal development and hint at a role for miR-106b up-regulation in the pathophysiology of epilepsy. +other 34785326 hsa-mir-181a Nephrotic Syndrome The (miR-142a-5p with miR-181a-5p and miR-30a-5p) was the best expression panel to diagnose new NS cases and predict steroid resistance. +lncRNA target 34785240 hsa-mir-126 Myocardial Ischemia MicroRNA-126 (miR-126) has been identified as the main regulator of compensatory angiogenesis; however, its role in MI is unclear. In summary, miR-126 regulates the occurrence and progression of angiogenesis during MI via HIF-1alpha and may be a potential new therapeutic target. +transcription factor target 34785144 hsa-mir-192 Inflammation CONCLUSION: Baicalein alleviated pyroptosis and inflammation in HP by inhibiting the NLRP3/Caspase-1 pathway through miR5p upregulation and TXNIP inhibition. +transcription factor target 34785144 hsa-mir-192 Syphilis CONCLUSION: Baicalein alleviated pyroptosis and inflammation in HP by inhibiting the NLRP3/Caspase-1 pathway through miR5p upregulation and TXNIP inhibition. +transcription factor target 34785144 hsa-mir-192 Pancreatitis CONCLUSION: Baicalein alleviated pyroptosis and inflammation in HP by inhibiting the NLRP3/Caspase-1 pathway through miR5p upregulation and TXNIP inhibition. +lncRNA target 34785106 hsa-mir-23a Liver Diseases, Alcoholic CONCLUSIONS: We first demonstrated that ISL could alleviate ALD, and further verified that ISL exerted protective effects through modulating miR-23a-3p/PGC-1alpha-mediated lipid metabolism in vivo and in vitro. +genetics_knock down_suppress 34784955 hsa-mir-20a Ovarian Neoplasms SMG1 was targeted by miR-320a, and its knockdown also reversed the regulation of miR-320a inhibitor on the proliferation and apoptosis of ovarian cancer cells. CONCLUSION: Curcumin restrained proliferation and facilitated apoptosis in ovarian cancer by regulating the circ-PLEKHM3/miR-320a/SMG1 axis. +genetics_overexpression_promote 34784841 hsa-mir-381 Sepsis Overexpression of miR +genetics_overexpression_promote 34784841 hsa-mir-381 Inflammation Overexpression of miR +genetics_overexpression_promote 34784837 hsa-mir-455 Intrauterine Adhesion 5p overexpression in UCMSCs helps to attenuate endometrial injury and repair damaged endometrium by activating SOCS3-mediated JAK/STAT3 signaling. +transcription factor target 34784802 hsa-mir-126 COVID-19 3p, miR-144 and miR-155 are the most important dysregulated miRNAs that could serve as biomarkers for diagnosing and indicating the severity of COVID-19. +transcription factor target 34784802 hsa-mir-144 COVID-19 3p, miR-144 and miR-155 are the most important dysregulated miRNAs that could serve as biomarkers for diagnosing and indicating the severity of COVID-19. +transcription factor target 34784802 hsa-mir-155 COVID-19 3p, miR-144 and miR-155 are the most important dysregulated miRNAs that could serve as biomarkers for diagnosing and indicating the severity of COVID-19. +transcription factor target 34784802 hsa-mir-146a COVID-19 3p, miR-144 and miR-155 are the most important dysregulated miRNAs that could serve as biomarkers for diagnosing and indicating the severity of COVID-19. +transcription factor target 34784802 hsa-mir-21 COVID-19 3p, miR-144 and miR-155 are the most important dysregulated miRNAs that could serve as biomarkers for diagnosing and indicating the severity of COVID-19. +transcription factor target 34784607 hsa-mir-1228 Diabetic Nephropathies RESULTS: The expression of THBS2 was significantly upregulated in diabetic nephropathy (DN) based on bioinformatics tools and identified as a direct target of miR-1228. +transcription factor target 34784607 hsa-mir-1228 Norrie disease RESULTS: The expression of THBS2 was significantly upregulated in diabetic nephropathy (DN) based on bioinformatics tools and identified as a direct target of miR-1228. miR-1228 was downregulated in DN and HG-damaged HK-2 cells. +genetics_knock down_promote 34784607 hsa-mir-1228 Hyperglycemia In terms of overexpression and knockdown experiments, Western blot analysis further revealed that miR-1228 inhibited the activation of the PI3K/AKT signaling pathway in HG-damaged HK-2 cells by regulating THBS2. +genetics_overexpression_promote 34784561 hsa-mir-1294 Dermatitis, Atopic Inflammation (P < 0.05) and epidermal barrier function destruction (P < 0.05) in AD was suppressed by overexpression of miR-1294 but enhanced by STAT3 upregulation and its downstream NF-kappaB pathway. +genetics_overexpression_promote 34784519 hsa-mir-1258 Carcinoma, Hepatocellular Moreover, ectopic overexpression of miR-1258 suppressed cell growth and metastasis in HCC, which was abolished by SERBP1 up-regulation. +exosome 34784377 hsa-mir-196a pancreatic adenocarcinoma qRT-PCR analysis of miRNA expression in EVs from PDAC cells revealed that expression of miR-196a and miR-1246, two previously identified miRNAs highly enriched in PDAC cell-derived exosomes, is significantly elevated in the OP1 group relative to the other EV groups. +exosome 34784377 hsa-mir-1246 pancreatic adenocarcinoma qRT-PCR analysis of miRNA expression in EVs from PDAC cells revealed that expression of miR-196a and miR-1246, two previously identified miRNAs highly enriched in PDAC cell-derived exosomes, is significantly elevated in the OP1 group relative to the other EV groups. +transcription factor target 34784311 hsa-mir-544 Arthritis 3p as a new potential therapeutic target for treating RA pain. +genetics_knock down_promote 34784267 hsa-mir-577 Glioblastoma E2F5 was a target of miR-577, and the effect of its knockdown on GBM progression was consistent with that of circFOXM1 silencing. +transcription factor target 34784010 hsa-mir-106a Carcinoma, Hepatocellular Besides, PTPN12 counteracted the promoting effects of miR-106a-5p on the viability, migration, invasion, and EMT of HCC cells. In conclusion, this study substantiates that PTPN12 inhibits the growth, migration, invasion, and EMT of HCC cells, and miR-106a-5p contributes to its dysregulation in HCC. +genetics_knock down_suppress 34783894 hsa-mir-543 Breast Neoplasms CONCLUSION: Our study suggested that SNHG14 knockdown hindered BC progression in vitro at least partly through acting as a ceRNA of miR-543 and modulating KLF7 expression, providing evidence for SNHG14 as a potential target for BC therapy. +genetics_knock down_promote 34783868 hsa-mir-204 Kidney Calculi Gain- and loss-of-function approaches were employed to alter the expression of miR-204/MUC4 so as to assess the detailed role of miR-204 in oxidative stress injury in renal tubular epithelial cells (RTECs) and calcium oxalate kidney-stone formation. +lncRNA target 34783641 hsa-mir-31 Breast Neoplasms We aimed to evaluate the effects of long-chain non-coding RNA (lncRNA) anti-differentiation non-coding RNA (ANCR) on the proliferation, invasion, and migration of breast cancer cells by targeting miR-331. LncRNA ANCR expressions in breast cancer and adjacent tissues, human breast cancer cells and mammary epithelial cells, and miR-331 expressions in interfering cell line MDA-MB-231 (MCF-7)-shANCR, negative control MDA-MB-231 (MCF-7)-shNC and blank control MDA-MB-231 (MCF-7) were detected by real-time quantitative PCR. +genetics_knock down_promote 34783632 hsa-mir-512 Arteriosclerosis Mechanistically, knockdown of miR +lncRNA target 34783627 hsa-mir-212 Acute Kidney Injury In conclusion, KCNQ1OT1 aggravates acute kidney injury by activating p38/NF-kappaB pathway via miR3p/MAPK1 axis in sepsis. +lncRNA target 34783627 hsa-mir-212 Sepsis In conclusion, KCNQ1OT1 aggravates acute kidney injury by activating p38/NF-kappaB pathway via miR3p/MAPK1 axis in sepsis. +lncRNA target 34783622 hsa-mir-204 Carcinoma, Renal Cell 5p reduction reversed the inhibitory effect of LINC01232 silencing on ccRCC cell function. +lncRNA target 34783303 hsa-mir-138 Parkinson Disease 5p/NFIB axis, providing new therapeutic targets for patients with PD. +transcription factor target 34783294 hsa-mir-27b Inflammation In the meanwhile, Gm5106 was identified as a direct target of miR-27b-3p that was inhibited by sevoflurane and related to inflammation suppression. +genetics_GWAS 34783292 hsa-mir-34a Osteoarthritis Using miRNA-based microarray analysis, we found that miR-34a was overexpressed in cartilage tissues of OA patients relative to patients with acute traumatic amputations. +genetics_knock down_promote 34783290 hsa-mir-200c Venous Thromboembolism VTE rats were injected with miR-200c-3p inhibitor for 24 h to investigate whether miR-200c-3p knockdown influences thrombus formation in vivo. +lncRNA target 34783233 hsa-mir-873 Carcinoma, Hepatocellular Moreover, GTPBP4 was identified as direct downstream target of miR +circRNA target 34783205 hsa-mir-545 Endometrial Neoplasms 3p/FAM98A axis, providing a potential therapeutic target for ECa. +genetics_overexpression_suppress 34783198 hsa-mir-411 Fibrosis, Skin Overexpression of miR +lncRNA target 34783160 hsa-mir-193a Melanoma In addition, we discovered that LINC01224 upregulated NR1D2 expression by sponging miR-193a-5p in melanoma cells. Overall, the data collected in this study suggest that LINC01224 exerts oncogenic effects in melanoma via the miR-193a-5p/NR1D2 axis. +lncRNA target 34782005 hsa-mir-339 Colorectal Neoplasms Our mechanistic investigations demonstrated, for the first time, that SNHG17 promotes tumor growth and metastasis through two different regulatory mechanisms, SNHG17-Trim23-PES1 axis and SNHG17-miR5p-FOSL2-SNHG17 positive feedback loop, which may be exploited for CRC therapy. +genetics_GWAS 34781979 hsa-mir-155 Femur Head Necrosis Stratified analysis showed that a MIR17HG SNP (rs7318578) and the MIR155HG SNPs (rs77218221, rs11911469, rs34904192 and rs4143370) were closely related to different unornamented phenotypes of steroid-induced ONFH. +other 34781940 hsa-mir-378a Atrial Fibrillation Two significant modules (red and blue) and hub miRNAs (hsa-miR-146b-5p and hsa-miR-378a-5p), which highly correlated with AF-related phenotype, were detected by WGCNA. +other 34781940 hsa-mir-146b Atrial Fibrillation Two significant modules (red and blue) and hub miRNAs (hsa-miR-146b-5p and hsa-miR-378a-5p), which highly correlated with AF-related phenotype, were detected by WGCNA. +circRNA target 34781898 hsa-mir-203 Leukemia, Myelogenous, Chronic, BCR-ABL Positive The deregulation of circ_0080145 and circ_0051886 is, at least partially, responsible for the development of IM chemoresistance in CML by regulating expression of ABL1 via modulating expression of miR-203 and miR-637. +circRNA target 34781898 hsa-mir-637 Leukemia, Myelogenous, Chronic, BCR-ABL Positive The deregulation of circ_0080145 and circ_0051886 is, at least partially, responsible for the development of IM chemoresistance in CML by regulating expression of ABL1 via modulating expression of miR-203 and miR-637. +lncRNA target 34781815 hsa-mir-1 Thyroid Cancer, Papillary 5p to upregulate SIDT2, thereby inhibiting the viability, proliferation, migration, invasion, and the secretion of vascular endothelial growth factor (VEGF) of PTC cells and angiogenesis of human umbilical vein endothelial cells (HUVECs). +other 34781814 hsa-mir-515 Squamous Cell Carcinoma of Head and Neck Thus, these findings highlight that circANKS1B might act as an oncogenic gene to facilitate the metastatic potential and cisplatin resistance in OSCC by sponging miR5p to regulate TGF-beta1. +other 34781178 hsa-mir-21 Stomach Neoplasms Herein, we report the novel fluorescent paper-based analytical devices (PADs) for detections of GC-related microRNA-21 (miRNA-21) and circular RNA from Hippocampus Abundant Transcript 1 gene (circRNA-HIAT1) with prominent reliability and sensitivity. +other 34781166 hsa-mir-455 Alzheimer Disease 3p against AD toxicities in reducing full-length APP and amyloid-beta (Abeta) levels, and also in reducing defective mitochondrial biogenesis, impaired mitochondrial dynamics and synaptic deficiencies. +other 34781085 hsa-mir-7 Acidosis In addition, acidosis had a strong effect on cell adhesion, which could be modulated by miR-7, miR-203 and miR-215. +other 34781085 hsa-mir-203 Acidosis In addition, acidosis had a strong effect on cell adhesion, which could be modulated by miR-7, miR-203 and miR-215. +lncRNA target 34780888 hsa-mir-1208 Atherosclerosis Altogether, HAND2-AS1 targeting miR-1208/SIRT1 axis alleviates the formation of foam cells within AS. +transcription factor target 34780785 hsa-mir-22 Atherosclerosis However, a certain role of miR-22 in the pathogenesis of atherosclerosis remains undetermined. Collectively, these evidences revealed that miR-22 inhibition promoted the atherosclerosis progression through activation of IRF5. +other 34780678 hsa-mir-519d Osteosarcoma We found that PD-L1 expression was positively correlated to cisplatin resistance and metastasis, whereas miR-519d-3p expression was reduced in cisplatin-resistant specimens and was negatively correlated to cisplatin resistance and metastasis of osteosarcoma. +other 34780054 hsa-mir-29c Carcinoma, Hepatocellular CONCLUSIONS: Our results revealed a novel role of miR-653 and miR-29c in regulation of expresion of CYPs involved in crucial biotransformation processes in liver, which are often deregulated during liver cancer progression. +other 34780054 hsa-mir-653 Carcinoma, Hepatocellular CONCLUSIONS: Our results revealed a novel role of miR-653 and miR-29c in regulation of expresion of CYPs involved in crucial biotransformation processes in liver, which are often deregulated during liver cancer progression. +transcription factor target 34779995 hsa-mir-674 Glioma 5p suppressed glioma cell proliferation and migration by targeting Cul4b. +transcription factor target 34779712 hsa-mir-222 Neural Tube Defects 3p regulates the Wnt/beta-catenin signaling pathway through Ddit4 inhibition in HT-22 cells, resulted in cell proliferation and apoptosis imbalance, and thus led to neural tube defects. +lncRNA target 34779502 hsa-mir-190b Pancreatic Carcinoma In addition, it was also found that miR190b directly targeted myocyte enhancer factor 2C (MEF2C) and transcription factor 4 (TCF4) in pancreatic cancer, thus serving as a tumor suppressor and a predictor of good prognosis in pancreatic cancer. +lncRNA target 34779493 hsa-mir-377 Uterine Cervical Neoplasms In conclusion, suppression of NEAT1 inhibited cell viability and migration, and promoted apoptosis of CC cells, and these effects were achieved through regulation of the miR377/FGFR1 axis. +other 34778942 hsa-mir-152 Carcinoma, Hepatocellular CONCLUSIONS: LncSNHG3 acted as an oncogene and promoted the EMT procession in HCC by binding miR3p and promoting JAK1 expression. +lncRNA target 34778905 hsa-mir-21 Osteoporosis CONCLUSION: In summary, LINC02381 repressed osteogenic differentiation of hUS-MSCs through sponging miR-21 to enhance KLF12-mediated inactivation of Wnt/beta-catenin pathway, indicating that LINC02381 might be a therapeutic target for osteoporosis. +lncRNA target 34778900 hsa-mir-34a Pulmonary Embolism RESULTS: MiR-34a-3p expression was down-regulated in APE patients, which attenuated the increment of mPAP and thickening of the pulmonary arterial walls in APE rats, accompanied with regulation of NOR-1 and PCNA levels. CONCLUSION: Up-regulated miR-34a-3p negatively regulates DUSP1 expression to inhibit PASMC proliferation, which, thus, may act on APE treatment by negatively regulating pulmonary vascular proliferation. +genetics_overexpression_suppress 34778448 hsa-mir-1226 Hypertension 3p and eNOS were, respectively, found in the PAH rats and rPAECs, and overexpressed miR +other 34778258 hsa-mir-181a Osteoarthritis Moreover, we observed that a tight correlation between miR-181a and miR-218 expression levels in healthy human cartilage tissue was disrupted in osteoarthritis (OA) highlighting the importance of the WNT-BMP signaling crosstalk for preventing OA. +other 34778258 hsa-mir-218 Osteoarthritis Moreover, we observed that a tight correlation between miR-181a and miR-218 expression levels in healthy human cartilage tissue was disrupted in osteoarthritis (OA) highlighting the importance of the WNT-BMP signaling crosstalk for preventing OA. +other 34778251 hsa-mir-129 Lymphoma, Large B-Cell, Diffuse In conclusion, we showed for the first time that the mir5P/ARID3A negative feedback loop modulates DLBCL progression and immune evasion by regulating PD-1/PD-L1. +other 34778090 hsa-mir-375 Squamous Intraepithelial Lesions In HPV 16-positive women, miR-375 positivity had higher sensitivity and NPV but lower specificity and PPV than that of cytology (>/=ASC-H and HSIL) in identifying CIN3+ and CIN2+. +other 34778090 hsa-mir-375 Cervical Intraepithelial Neoplasia The immediate CIN3+ risk of miR-375 positivity was 19.8% (61/308) in HPV-positive, 10.8% (22/204) in HR12-positive, and 43.5% (37/85) in HPV16-positive women, respectively. +other 34778090 hsa-mir-375 Uterine Cervical Neoplasms CONCLUSION: The detection of miR-375 in cervical exfoliated cells may be an optional method for triaging primary HPV-positive women in population-based cervical cancer screening. +other 34778090 hsa-mir-375 Uterine Cervical Diseases RESULTS: In valid 9,972 women aged 25-65, miR-375 expression showed a downward trend along with an increase in cervical lesion severity. +other 34778090 hsa-mir-375 Papillomavirus Infections CONCLUSION: The detection of miR-375 in cervical exfoliated cells may be an optional method for triaging primary HPV-positive women in population-based cervical cancer screening. +transcription factor target 34778074 hsa-mir-29c Stomach Neoplasms Furthermore, we identified miR-29c as a negative regulator of JARID1B in GC. pylori caused downregulation of miR-29c in human GC and thereby contributed to JARID1B upregulation through relieving posttranscriptional regulation. +transcription factor target 34778021 hsa-mir-4443 Esophageal Squamous Cell Carcinoma 5p and miR-4443 may serve as a novel molecular target for ESCC treatment. +transcription factor target 34778021 hsa-mir-17 Esophageal Squamous Cell Carcinoma 5p and miR-4443 may serve as a novel molecular target for ESCC treatment. +exosome 34777698 hsa-mir-4454 Carcinoma, Hepatocellular Meanwhile, we certified that miR-4454 in exosomes could provide a novel and effective mechanism for HCC function. +genetics_overexpression_promote 34777696 hsa-mir-21 Glioma 5p or overexpression of CASKIN1 annulled the effects of LINC00294 silencing on mitochondrial function and glioma cell apoptosis under hypoxia. +lncRNA target 34777635 hsa-let-7f Aortic Aneurysm, Abdominal Furthermore, the expression of SOD2 and CCR7 may be regulated by hsa_circ_0011449/hsa_circ_0081968/hsa-let-7f-5p; the expression of PGRMC1 may be regulated by hsa_circ_0011449/hsa_circ_0081968-hsa-let-7f-5p/hs CONCLUSION: In conclusion, the ceRNA interaction axis we identified may be an important target for the treatment of abdominal aortic aneurysms. +genetics_knock down_promote 34777589 hsa-mir-1179 Gallbladder Neoplasms Notably, E2F2 knockdown partially hindered the effects of TMPO-AS1/miR-1179 on the proliferation and metastasis of GBC cell lines. +genetics_GWAS 34777472 hsa-mir-3928 Arthritis, Rheumatoid Overall, 6 novel miRNA SNPs including rs1414273 (miR-548ac, p = 8.26 x 10(-4)), rs2620381 (miR-627, p = 2.55 x 10(-3)), rs4285314 (miR-3135b, p = 1.10 x 10(-13)), rs28477407 (miR-4308, p = 3.44 x 10(-5)), rs5997893 (miR-3928, p = 5.9 x 10(-3)) and rs45596840 (miR-4482, p = 6.6 x 10(-3)) were confirmed to be significantly associated with RA in a Chinese population. +genetics_GWAS 34777472 hsa-mir-4482 Arthritis, Rheumatoid Overall, 6 novel miRNA SNPs including rs1414273 (miR-548ac, p = 8.26 x 10(-4)), rs2620381 (miR-627, p = 2.55 x 10(-3)), rs4285314 (miR-3135b, p = 1.10 x 10(-13)), rs28477407 (miR-4308, p = 3.44 x 10(-5)), rs5997893 (miR-3928, p = 5.9 x 10(-3)) and rs45596840 (miR-4482, p = 6.6 x 10(-3)) were confirmed to be significantly associated with RA in a Chinese population. +genetics_GWAS 34777472 hsa-mir-4308 Arthritis, Rheumatoid Overall, 6 novel miRNA SNPs including rs1414273 (miR-548ac, p = 8.26 x 10(-4)), rs2620381 (miR-627, p = 2.55 x 10(-3)), rs4285314 (miR-3135b, p = 1.10 x 10(-13)), rs28477407 (miR-4308, p = 3.44 x 10(-5)), rs5997893 (miR-3928, p = 5.9 x 10(-3)) and rs45596840 (miR-4482, p = 6.6 x 10(-3)) were confirmed to be significantly associated with RA in a Chinese population. +genetics_GWAS 34777472 hsa-mir-135b Arthritis, Rheumatoid Overall, 6 novel miRNA SNPs including rs1414273 (miR-548ac, p = 8.26 x 10(-4)), rs2620381 (miR-627, p = 2.55 x 10(-3)), rs4285314 (miR-3135b, p = 1.10 x 10(-13)), rs28477407 (miR-4308, p = 3.44 x 10(-5)), rs5997893 (miR-3928, p = 5.9 x 10(-3)) and rs45596840 (miR-4482, p = 6.6 x 10(-3)) were confirmed to be significantly associated with RA in a Chinese population. +other 34777462 hsa-mir-16 Leukemia, Myeloid, Acute 5p/CCL5 may play an important role in AML. +other 34777462 hsa-mir-17 Leukemia, Myeloid, Acute 5p/CCL5 may play an important role in AML. +circulation_biomarker_diagnosis_up 34777204 hsa-mir-181b Hemorrhagic Stroke 5p, and miR-27b-3p-were significantly upregulated in the plasma of rats 3 h after permanent MCAO, whereas four other different miRNAs-miR +circulation_biomarker_diagnosis_up 34777204 hsa-mir-27b Hemorrhagic Stroke 5p, and miR-27b-3p-were significantly upregulated in the plasma of rats 3 h after permanent MCAO, whereas four other different miRNAs-miR +circulation_biomarker_diagnosis_up 34777204 hsa-mir-101a Hemorrhagic Stroke 5p, and miR-27b-3p-were significantly upregulated in the plasma of rats 3 h after permanent MCAO, whereas four other different miRNAs-miR +circulation_biomarker_diagnosis_up 34777204 hsa-mir-150 Hemorrhagic Stroke 5p, and miR-27b-3p-were significantly upregulated in the plasma of rats 3 h after permanent MCAO, whereas four other different miRNAs-miR +circulation_biomarker_diagnosis_up 34777204 hsa-mir-16 Hemorrhagic Stroke 5p, and miR-27b-3p-were significantly upregulated in the plasma of rats 3 h after permanent MCAO, whereas four other different miRNAs-miR +circulation_biomarker_diagnosis_up 34777204 hsa-let-7b Hemorrhagic Stroke 5p, and miR-27b-3p-were significantly upregulated in the plasma of rats 3 h after permanent MCAO, whereas four other different miRNAs-miR +lncRNA target 34776969 hsa-mir-149 Arthritis, Rheumatoid Thus, we elucidate a previously unknown mechanism between circRNAs and RA, and ATO has a significant protective effect on RA-FLS and CIA synovium via its inhibition of the angiogenic functional module of circHIPK3/miR5p/FOXO1/VEGF, suggesting great potential for the combination therapy of ATO with circHIPK3 silencing. +other 34776961 hsa-mir-122 Lipid Metabolism Disorders kingianum can reduce insulin resistance and restore the gut microbiota in a rat model of aberrant lipid metabolism by down regulating miR-122. +transcription factor target 34776924 hsa-mir-214 Parkinson Disease We previously identified that miR-31 and miR-214 were dysregulated in PD. +other 34776924 hsa-mir-1 Parkinson Disease In addition, the expression of miR-214 was lower in aPD patients compared to both dnPD or pPD patients, while the expression of miR-31 was higher in aPD patients compared to dnPD patients. +lncRNA target 34776870 hsa-mir-106b Neurodegenerative Diseases Our results suggest propofol inhibits microglial activation via miR-106b/Pi3k/Akt axis, shedding light on a novel molecular mechanism of propofol-mediated immunomodulatory effects and implying propofol as potential therapeutics for treating neuroinflammation-related neurodegenerative diseases. +lncRNA target 34776870 hsa-mir-106b Neurogenic Inflammation Our results suggest propofol inhibits microglial activation via miR-106b/Pi3k/Akt axis, shedding light on a novel molecular mechanism of propofol-mediated immunomodulatory effects and implying propofol as potential therapeutics for treating neuroinflammation-related neurodegenerative diseases. +transcription factor target 34776863 hsa-mir-1254 sporatic amyotrophic lateral sclerosis Two miRNAs were dysregulated in all three tissues: miR3p was increased in ALS, and miR-1254 was reduced in ALS. +transcription factor target 34776863 hsa-mir-342 sporatic amyotrophic lateral sclerosis Two miRNAs were dysregulated in all three tissues: miR3p was increased in ALS, and miR-1254 was reduced in ALS. +target gene 34776628 hsa-mir-194 Psoriasis Circ-IGF1R plays a significant role in psoriasis via regulation of a miR-194-5p/CDK1 axis. +other 34776451 hsa-let-7d Alzheimer Disease 5p, miR-181a) and females (miR-150, miR-539). +other 34776451 hsa-mir-181a Alzheimer Disease 5p, miR-181a) and females (miR-150, miR-539). +other 34776451 hsa-let-7i Alzheimer Disease 5p, miR-181a) and females (miR-150, miR-539). +other 34776451 hsa-mir-151 Alzheimer Disease 5p, miR-181a) and females (miR-150, miR-539). +other 34776451 hsa-mir-539 Alzheimer Disease 5p, miR-181a) and females (miR-150, miR-539). +other 34776451 hsa-mir-132 Alzheimer Disease 5p, miR-181a) and females (miR-150, miR-539). +other 34776451 hsa-mir-23a Alzheimer Disease 5p, miR-181a) and females (miR-150, miR-539). +other 34776451 hsa-mir-34b Alzheimer Disease 5p, miR-181a) and females (miR-150, miR-539). +other 34776451 hsa-mir-99a Alzheimer Disease 5p, miR-181a) and females (miR-150, miR-539). +other 34776451 hsa-mir-126 Alzheimer Disease 5p, miR-181a) and females (miR-150, miR-539). +other 34776451 hsa-mir-150 Alzheimer Disease 5p, miR-181a) and females (miR-150, miR-539). +exosome 34775889 hsa-mir-129 Colonic Neoplasms Exosomes containing miRNA +other 34775880 hsa-mir-381 Asthma 3p-mediated PPP3CA/calcineurin signalling regulated iNOS transcription in macrophages and bronchoalveolar lavage cells (BALCs) after acute MDI exposure; however, whether PPP3CA/calcineurin signalling participates in regulation of other asthma-associated mediators secreted by macrophages/BALCs after MDI exposure is unknown.Several asthma-associated, macrophage-secreted mediator mRNAs from MDI exposed murine BALCs and MDI-glutathione (GSH) conjugate treated differentiated THP-1 macrophages were analysed using RT-qPCR.Endogenous IL1B, TNF, CCL2, CCL3, CCL5, and TGFB1 were upregulated in MDI or MDI-GSH conjugate exposed BALCs and macrophages, respectively. +transcription factor target 34775599 hsa-mir-590 Inflammation Therefore, miR3p may be a promising therapeutic target for SLE and other Th17 cell-dependent autoimmune diseases. +transcription factor target 34775599 hsa-mir-590 Lupus Erythematosus, Systemic Therefore, miR3p may be a promising therapeutic target for SLE and other Th17 cell-dependent autoimmune diseases. +lncRNA target 34775495 hsa-mir-155 Precursor Cell Lymphoblastic Leukemia-Lymphoma 5p can promote the development of cALL via the regulation on CBL-mediated IRF4/CDK6 axis. +lncRNA target 34775467 hsa-mir-942 Carcinoma, Renal Cell This study provides a novel regulatory model of circRNA via forming a positive-feedback loop that perpetuates the circESRP1/miR-3942/CTCF axis, suggesting that this signaling may serve as a novel target for the treatment of ccRCC. +lncRNA target 34775378 hsa-mir-15a Glioma Present study showed that deletion of miR-15a inhibited the activation of EMT signaling via targeting Smad7, thus suppressed the tumorigenesis and tumor growth of glioma. +transcription factor target 34775375 hsa-mir-6745 Stomach Neoplasms TIMP1 axis regulates Wnt/betacatenin signaling and participates in GC tumorigenesis and provide a potential therapeutic target for preventing GC progression. +other 34775268 hsa-mir-195 Salivary Gland Pleomorphic Adenoma Furthermore, T042819 was significantly upregulated in SGPA, which may upregulate PLAG1 by sponging has-miR195-5p. +target gene 34774989 hsa-mir-130b Non-alcoholic Fatty Liver Disease LncRNA HOTAIR regulates the lipid accumulation in non-alcoholic fatty liver disease via miR-130b-3p/ROCK1 axis. +genetics_overexpression_suppress 34774846 hsa-mir-146a Intestinal Diseases Finally, we observed that miR-146a-5p overexpression inhibits autophagy and attenuates intestinal I/R injury via the PRKAA/mTOR pathway by targeting TXNIP in vivo. +transcription factor target 34774740 hsa-mir-702 Sepsis 3p played an important role in the pathogenesis of sepsis cardiomyopathy via targeting NOD1, suggesting that miR +transcription factor target 34774740 hsa-mir-702 Myocarditis 3p played an important role in the pathogenesis of sepsis cardiomyopathy via targeting NOD1, suggesting that miR +transcription factor target 34774740 hsa-mir-702 Susac Syndrome 3p played an important role in the pathogenesis of sepsis cardiomyopathy via targeting NOD1, suggesting that miR +transcription factor target 34774740 hsa-mir-702 Cardiomyopathies 3p played an important role in the pathogenesis of sepsis cardiomyopathy via targeting NOD1, suggesting that miR +other 34774537 hsa-mir-155 Lymphoma, T-Cell, Cutaneous Downregulation of miR-155, miR-130, and miR-21 in CTCL cell lines decreased CTCL cell growth and facilitated CD8(+) T-cell-mediated cytotoxic activity, with concordant production of IFN-gamma and CD107a expression. +other 34774537 hsa-mir-130 Lymphoma, T-Cell, Cutaneous Downregulation of miR-155, miR-130, and miR-21 in CTCL cell lines decreased CTCL cell growth and facilitated CD8(+) T-cell-mediated cytotoxic activity, with concordant production of IFN-gamma and CD107a expression. +other 34774537 hsa-mir-21 Lymphoma, T-Cell, Cutaneous Downregulation of miR-155, miR-130, and miR-21 in CTCL cell lines decreased CTCL cell growth and facilitated CD8(+) T-cell-mediated cytotoxic activity, with concordant production of IFN-gamma and CD107a expression. +other 34774515 hsa-mir-451 Breast Neoplasms In addition, our cancer specificity algorithm identified candidate biomarkers for differentiating neoplastic and nonneoplastic tissue samples (eg, miR-144 and miR-375 in breast cancer and miR-375 and miR-451 in skin cancer). +other 34774515 hsa-mir-375 Skin Neoplasms In addition, our cancer specificity algorithm identified candidate biomarkers for differentiating neoplastic and nonneoplastic tissue samples (eg, miR-144 and miR-375 in breast cancer and miR-375 and miR-451 in skin cancer). +other 34774515 hsa-mir-451 Skin Neoplasms In addition, our cancer specificity algorithm identified candidate biomarkers for differentiating neoplastic and nonneoplastic tissue samples (eg, miR-144 and miR-375 in breast cancer and miR-375 and miR-451 in skin cancer). +other 34774515 hsa-mir-144 Skin Neoplasms In addition, our cancer specificity algorithm identified candidate biomarkers for differentiating neoplastic and nonneoplastic tissue samples (eg, miR-144 and miR-375 in breast cancer and miR-375 and miR-451 in skin cancer). +other 34774515 hsa-mir-375 Breast Neoplasms In addition, our cancer specificity algorithm identified candidate biomarkers for differentiating neoplastic and nonneoplastic tissue samples (eg, miR-144 and miR-375 in breast cancer and miR-375 and miR-451 in skin cancer). +other 34774515 hsa-mir-144 Breast Neoplasms In addition, our cancer specificity algorithm identified candidate biomarkers for differentiating neoplastic and nonneoplastic tissue samples (eg, miR-144 and miR-375 in breast cancer and miR-375 and miR-451 in skin cancer). +other 34774083 hsa-mir-515 Osteosarcoma Circular RNA circPIP5K1A contributes to cancer stemness of osteosarcoma by miR-515-5p/YAP axis. +genetics_knock down_promote 34774079 hsa-mir-187 Ovarian Neoplasms Gain- and loss-of-function studies of circ_0000745, microRNA (miR) +genetics_knock down_promote 34774078 hsa-mir-1297 Uterine Cervical Neoplasms Moreover, miR-1297 inhibition and RCN2 overexpression could counteract the inhibitory effects of DUXAP8 knockdown on the malignant phenotypes of CC cells. CONCLUSIONS: DUXAP8 promotes malignant behaviors in CC cells via regulating miR-1297/RCN2 axis. +lncRNA target 34774019 hsa-mir-1915 Carcinoma, Non-Small-Cell Lung 3p significantly suppressed migration, invasion and epithelial-mesenchymal transition (EMT) in NSCLC cells. +lncRNA target 34773997 hsa-mir-17 Congenital central hypoventilation syndrome The axis of Stat5a/Dnmt3a/miR5p/Cdkn1a potentially provides a treatment target for cMPNs. +lncRNA target 34773997 hsa-mir-17 Charcot-Marie-Tooth disease type 1B The axis of Stat5a/Dnmt3a/miR5p/Cdkn1a potentially provides a treatment target for cMPNs. +lncRNA target 34773846 hsa-mir-155 Pulmonary Disease, Chronic Obstructive In this study, we used an established PM2.5-aggravated COPD rat model in vivo to evaluate the protective effect of ECC-BYF, and focused on its antioxidative role in PM2.5-stimulated bronchial epithelial cells via regulating microRNA (miR)-155/ forkhead box class O3a (FOXO3a) pathway. In conclusion, ECC-BYF can protect pre-existing COPD against PM2.5 contamination by exerting a profound antioxidative influence via regulating miR-155/FOXO3a signaling. +lncRNA target 34773593 hsa-mir-134 Parkinson Disease JHDM1D-AS1 protected against MPP -induced neuron injury via miR5p/PIK3R3 axis, suggesting the potential involvement of this axis in PD process. +genetics_knock down_promote 34773443 hsa-mir-346 Colorectal Neoplasms The present study indicated that miR-346 knockdown repressed cell growth in CRC cells by upregulating LHX6, and this was associated with inactivation of the Akt/mTOR pathway. +circulation_biomarker_diagnosis_ns 34773365 hsa-mir-146a Tuberculosis Subsequently, we discovered that miR-146a-5p, which may target UBE2L6, is reduced in peripheral blood mononuclear cells (PBMC) and plasma of TB, and it also had certain diagnostic efficiency(AUC=0.791). In brief, we demonstrated that UBE2L6 as well as miR-146a-5p is a potential biomarker for TB and UBE2L6,which may also plays important role in TB by, at least, modulating Mtb-infected macrophage apoptosis. +lncRNA target 34772911 hsa-mir-22 Glioblastoma 3p inhibitor offsets the HNF1A-AS1 silencing induced suppression in malignant behaviors of GBM cells. +lncRNA target 34772428 hsa-mir-497 Carcinoma, Non-Small-Cell Lung CONCLUSION: By targeting CDCA4, miR +lncRNA target 34772311 hsa-mir-27b Obesity OBJECTIVE: To investigate the effect of liraglutide on the browning of white fat and the suppression of obesity via regulating microRNA (miR)-27b in vivo and in vitro. +lncRNA target 34771727 hsa-mir-21 Colorectal Neoplasms The results demonstrate that miR-21 can induce CRC or colitis-associated cancer (CAC) in ImiR-21 through the PI3K/AKT, PDCD4/TNF-alpha, and IL-6/STAT3 signaling network. Hence, our findings indicate that miR-21 is critical for the development of CRC/CAC via the PI3K/AKT, STAT3, and PDCD4/TNF-alpha signaling networks. +lncRNA target 34771727 hsa-mir-21 Colitis-Associated Neoplasms The results demonstrate that miR-21 can induce CRC or colitis-associated cancer (CAC) in ImiR-21 through the PI3K/AKT, PDCD4/TNF-alpha, and IL-6/STAT3 signaling network. Hence, our findings indicate that miR-21 is critical for the development of CRC/CAC via the PI3K/AKT, STAT3, and PDCD4/TNF-alpha signaling networks. +lncRNA target 34771465 hsa-mir-100 Melanoma 5p and 125b-5p are potential markers of response to PD-1 inhibitors, and further evaluation of these microRNA-mRNA interactions may yield further insight into melanoma resistance to PD-1 inhibitors. +other 34771422 hsa-mir-21 Multiple Myeloma 5p are differently expressed between MM patients and healthy controls. +circulation_biomarker_diagnosis_ns 34771422 hsa-mir-29b Multiple Myeloma Interestingly, circulating levels of miR-29b-3p correlated with cervical and thoracic vertebral lesions, while miR5p correlated with thoracic lesions. +other 34771422 hsa-mir-29c Multiple Myeloma Additionally, miR-29c-3p was decreased in patients with osteolytic lesions compared with patients without bone disease. +other 34771422 hsa-mir-20a Multiple Myeloma 5p are differently expressed between MM patients and healthy controls. +other 34771422 hsa-mir-16 Multiple Myeloma 5p are differently expressed between MM patients and healthy controls. +circulation_biomarker_diagnosis_ns 34771422 hsa-mir-195 Multiple Myeloma Interestingly, circulating levels of miR-29b-3p correlated with cervical and thoracic vertebral lesions, while miR5p correlated with thoracic lesions. +lncRNA target 34769388 hsa-mir-204 Squamous Cell Carcinoma of Head and Neck Conclusions: This study identifies differentially expressed miRs in stromal fibroblasts of OSCC lesions compared with normal oral mucosa and it reveals that one of the significantly downregulated miRs in CAF, miR-204, has a tumor-suppressive function through inhibition of fibroblast migration by modulating the expression of several different molecules in addition to directly targeting ITGA11. +other 34769292 hsa-mir-132 Laron Syndrome 3p levels, with ensuing reduction in SIRT1 gene expression. +exosome 34769265 hsa-mir-122 Pulmonary Disease, Chronic Obstructive Of these, miR5p was three- or five-fold downregulated among the lung-tissue-derived exosomes of COPD patients as compared to healthy non-smokers and smokers, respectively. +exosome 34769265 hsa-mir-122 Pulmonary Fibrosis Of these, miR5p was three- or five-fold downregulated among the lung-tissue-derived exosomes of COPD patients as compared to healthy non-smokers and smokers, respectively. +other 34769160 hsa-mir-1 Mouth Neoplasms NUMB-MCT1/MCT4 regulatory cascade is present in oral carcinoma. +lncRNA target 34769029 hsa-mir-363 Cerebral Hemorrhage The expression of miRNA363-5p was inhibited and the expression of P2RX4 was upregulated in sciatic nerve injury. This study suggests that a double-negative feedback loop between miRNA363-5p and P2RX4 contributes to the dedifferentiation and migration of Schwann cells after nerve injury. +lncRNA target 34768991 hsa-mir-877 Arthritis, Rheumatoid The possible target genes of miR +lncRNA target 34768968 hsa-mir-29b Rubella Syndrome, Congenital During this process, epithelial-mesenchymal transition (EMT) plays an important role in dysregulated remodeling and both microRNA (miR)-29b and heat shock protein 47 (HSP47) may be engaged in the pathophysiology of CRS. These results suggested the importance of miR-29b and HSP47 in pathologic tissue remodeling progression in CRS. +transcription factor target 34768749 hsa-mir-541 Spinal muscular atrophy with respiratory distress 1 5p in alveolar epithelial cells, promoting EMT and contributing to RIPF by targeting Slug. +transcription factor target 34768749 hsa-mir-541 Radiation-Induced Pulmonary Fibrosis 5p in alveolar epithelial cells, promoting EMT and contributing to RIPF by targeting Slug. +lncRNA target 34768615 hsa-mir-34a Lupus Erythematosus, Systemic Enrichment analysis confirmed the implication of MIR34A in the SLE pathway by targeting several genes related to SLE etiopathology. +other 34768564 hsa-mir-451a Hemolysis To test the clinical usefulness of miR-451a as a biomarker of hemolytic diseases, we analyzed miRNAs of samples from 10 normal subjects, 30 leftover samples in the clinical laboratory, and 20 samples from patients with hemolytic diseases. +lncRNA target 34768379 hsa-mir-34b Leptomeningeal Metastasis Among 30 miRNAs identified for LM-specific biomarkers via a Prediction Analysis of Microarrays, miR5p and miR-34b-3p were confirmed in both the discovery and validation samples (n = 23). +lncRNA target 34768379 hsa-mir-335 Leptomeningeal Metastasis Among 30 miRNAs identified for LM-specific biomarkers via a Prediction Analysis of Microarrays, miR5p and miR-34b-3p were confirmed in both the discovery and validation samples (n = 23). +exosome 34768151 hsa-mir-6924 Osteolysis In brief, our study demonstrates that BMMSC(Scx)-exos or miR5p could serve as a potential therapy for the treatment of osteolysis during tendon-bone healing and improve the outcome. +exosome 34768001 hsa-mir-146a Depression Collectively, these results indicate that miR-146a-5p can function as a critical factor regulating neurogenesis under conditions of pathological processes resulting from depression and suggest that microglial exosomes generate new crosstalk channels between glial cells and neurons. +circulation_biomarker_diagnosis_ns 34767935 hsa-mir-150 Leukemia miR150 expression in leukemic cell lines and in blood collected from leukemia patients with diverse outcomes was evaluated by quantitative RT-PCR. Levels of circulating miR150 were found to be decreased after radiation in leukemia patients and exhibited an inverse correlation with recurrence. +genetics_knock down_promote 34767926 hsa-mir-210 Stomach Neoplasms Gain- and loss-of-function studies demonstrate that miR-210 and MIR210HG synergistically promote the migration and invasion of GC cells in vitro. +transcription factor target 34767797 hsa-mir-125a Pulmonary Fibrosis Our findings suggest that ghrelin attenuates TGF-beta1-induced pulmonary fibrosis via the miR-125a-5p/KLF13 axis, which supports ghrelin as a new therapeutic agent against pulmonary fibrosis by antagonizing the TGF-beta1 signaling pathway. +lncRNA target 34767742 hsa-mir-378a Nasopharyngeal Carcinoma Moreover, miR-378a-3p plays a suppressive role in NPC cells. +target gene 34767738 hsa-mir-141 Uterine Cervical Neoplasms miR-141-5p Affects the Cell Proliferation and Apoptosis by Targeting BTG1 in Cervical Cancer. +other 34767733 hsa-mir-199 Stomach Neoplasms A four-miRNA expression signature (involving two protective miRNAs, miR-200b and miR-103a, and two risk ones miR-199 and miR-152) was predicted as a specific indicator for GC chemoresistance (p=0.00053; hazard ratio=8.63), outperforming those clinicopathological factors. +other 34767733 hsa-mir-103a Stomach Neoplasms A four-miRNA expression signature (involving two protective miRNAs, miR-200b and miR-103a, and two risk ones miR-199 and miR-152) was predicted as a specific indicator for GC chemoresistance (p=0.00053; hazard ratio=8.63), outperforming those clinicopathological factors. +other 34767733 hsa-mir-200b Stomach Neoplasms A four-miRNA expression signature (involving two protective miRNAs, miR-200b and miR-103a, and two risk ones miR-199 and miR-152) was predicted as a specific indicator for GC chemoresistance (p=0.00053; hazard ratio=8.63), outperforming those clinicopathological factors. +genetics_knock down_promote 34767727 hsa-mir-124 Adenocarcinoma of Lung 3p depletion reversed the suppression of PTPRG-AS1 silence on LUAD cell behaviors, but then CCND1 knockdown countervailed the promoting influence of downregulated miR +lncRNA target 34767671 hsa-mir-145 Aortic Dissection CONCLUSION: Our results confirmed that mechanical stretch-induced phenotypic transformation of VSMCs to promote AD via upregulation of KLF4; this mechanism was regulated by miR-145, which directly modulated KLF4 expression and VSMC differentiation. +lncRNA target 34766707 hsa-mir-455 Necrobiotic Disorders These data suggest that microcrystalline silica can induce significant inflammation and pyroptosis in human primary AEC through NLRP3 inflammasome pathway and NF-kappaB signaling pathway at both the gene and protein levels, and the possible mechanism could be miR3p mediated ceRNA hypothesis. +lncRNA target 34766707 hsa-mir-455 Inflammation These data suggest that microcrystalline silica can induce significant inflammation and pyroptosis in human primary AEC through NLRP3 inflammasome pathway and NF-kappaB signaling pathway at both the gene and protein levels, and the possible mechanism could be miR3p mediated ceRNA hypothesis. +lncRNA target 34766670 hsa-mir-101 Squamous Cell Carcinoma of Head and Neck These findings demonstrated the oncogenic role of SNHG6, which promotes OSCC progression by regulating the expression of EZH2 through its interaction with miR +circulation_biomarker_diagnosis_up 34766525 hsa-mir-29a Myopia METHODS: The miR-29a expression level was detected in the aqueous humor and peripheral blood plasma of 21 high myopic patients and eight cataract control patients using quantitative polymerase chain reaction. +genetics_overexpression_promote 34766472 hsa-mir-1286 Arthritis, Rheumatoid Overexpression of BZRAP1-AS1 reduced the miR-1286 expression which in turn increased the COL5A2 expression, thereby relieving the excessive proliferation and limited apoptosis in RA-HFLS. +genetics_overexpression_promote 34765599 hsa-mir-512 Nasopharyngeal Carcinoma Conclusion: Circ_0000215 is overexpressed in NPC and exerts oncogenic effects in NPC through regulating miR +lncRNA target 34765550 hsa-mir-299 Carcinoma, Hepatocellular Mechanically, FAM99A interacted with EIF4B to inhibit gp130 and gp80 translation, which then interacted with miR5p to upregulate SOCS3, causing the JAK2 pathway to inhibit STAT3 phosphorylation, so that JAK2/STAT3 was blocked in HCC cells. +genetics_overexpression_promote 34765296 hsa-mir-545 Carcinoma, Non-Small-Cell Lung Our results showed that lncRNA NR2F2-AS1, c-Met, BVR and ATF-2 were overexpressed while miR +other 34765025 hsa-mir-335 Ischemic Stroke The expression levels of miR-335 and miR-495 in the IS group were significantly lower compared with the control group (P<0.05). +other 34765025 hsa-mir-495 Ischemic Stroke The expression levels of miR-335 and miR-495 in the IS group were significantly lower compared with the control group (P<0.05). +transcription factor target 34765019 hsa-mir-519d Osteoarthritis, Post-Traumatic In conclusion, reduction of miR-519d-3p in the synovium and SF resulted in the upregulation of VEGF in patients with PTOA, and miR-519d-3p may be a potential therapeutic target of PTOA. +circulation_biomarker_diagnosis_ns 34765018 hsa-mir-23a Diabetic Retinopathy The elevated VEGF expression in the blood and tears of patients with DR may be related to the reduced miRNA-23a expression. +genetics_overexpression_suppress 34765013 hsa-mir-139 Breast Neoplasms 5p expression in BC cells was obviously low, while MEX3A was significantly overexpressed. +transcription factor target 34765002 hsa-mir-1 Ataxia Neuropathy Spectrum In conclusion, YQHX alleviates H/R-induced cardiomyocyte apoptosis by inhibiting miR-1 expression, suggesting the potential of YQHX in preventing MIRI. +target gene 34764975 hsa-mir-25 Stomach Neoplasms miR-25 Regulates Gastric Cancer Cell Growth and Apoptosis by Targeting EGR2. +exosome 34764819 hsa-mir-326 Osteoarthritis CONCLUSION: BMSC-Exos can deliver miR-326 to chondrocytes and cartilage and improve OA by targeting HDAC3 and STAT1//NF-kappaB p65 to inhibit pyroptosis of chondrocytes and cartilage. +exosome 34764819 hsa-mir-326 Cartilage Diseases CONCLUSION: BMSC-Exos can deliver miR-326 to chondrocytes and cartilage and improve OA by targeting HDAC3 and STAT1//NF-kappaB p65 to inhibit pyroptosis of chondrocytes and cartilage. +genetics_knock down_promote 34764804 hsa-mir-590 Angelman Syndrome Knockdown of ZEB1-AS1 alleviates ox-LDL-induced endothelial cell injury by regulating the miR +lncRNA target 34764801 hsa-mir-205 Acute Kidney Injury Resveratrol alleviates sepsis-induced acute kidney injury by deactivating the lncRNA MALAT1/MiR-205 axis. +lncRNA target 34764801 hsa-mir-205 Sepsis Resveratrol alleviates sepsis-induced acute kidney injury by deactivating the lncRNA MALAT1/MiR-205 axis. +circulation_biomarker_diagnosis_down 34764785 hsa-mir-345 Leukemia, Myeloid, Acute 5p was a target of circNPM1 and was downregulated in AML serum and cells. +target gene 34764730 hsa-mir-4425 Breast Neoplasms Ginsenoside Rh2 upregulates long noncoding RNA STXBP5-AS1 to sponge microRNA-4425 in suppressing breast cancer cell proliferation. +lncRNA target 34764698 hsa-mir-940 Adenocarcinoma of Lung 3p were determined via RT-qPCR in LUAD tissues and cells. +circulation_biomarker_diagnosis_up 34764695 hsa-mir-122 Colorectal Neoplasms 5p in the serum of patients with colorectal cancer correlates with the severity of myelosuppression caused by chemotherapy, and miR +circulation_biomarker_diagnosis_up 34764695 hsa-mir-122 Lung Neoplasms 5p in the serum of patients with colorectal cancer correlates with the severity of myelosuppression caused by chemotherapy, and miR +genetics_GWAS 34763855 hsa-mir-169 Dehydration Overall, our findings implied that the miR169n-NF-YA8 regulatory module could serve as a potential target for genetic improvement of drought resistance in B. +exosome 34763521 hsa-mir-23-2 Myocardial Reperfusion Injury CONCLUSIONS: We demonstrate for the first time that MI/R causes significant adipocyte ER stress and endocrine dysfunction by releasing miR27-24 cluster-enriched small extracellular vesicle. +genetics_overexpression_promote 34763405 hsa-mir-296 Squamous Cell Carcinoma of Head and Neck 5p, cell viability, clone formation red number, migration rate, number of invasive cells, S phase cell ratio, glu consumption, alpha-KG production, ATP concentration, cyclinD1, GLS1 and TAGLN2 proteins in OSCC cells after overexpression of miR +other 34763233 hsa-mir-92a Melanoma Finally, using bioinformatics analysis, we predicted that PAX8-AS1/Z83843.1-miR-92a-3p-IFIT2 axis might play crucial roles in the development and progression of SKCM. +other 34763043 hsa-mir-216b Diabetes Mellitus, Type 2 5p, and hsa-miR-216b-5p in the T2DM group was higher (P<0.05). +other 34763043 hsa-mir-9 Diabetes Mellitus, Type 2 5p, and hsa-miR-216b-5p in the T2DM group was higher (P<0.05). +other 34763043 hsa-mir-150 Diabetes Mellitus, Type 2 5p, and hsa-miR-216b-5p in the T2DM group was higher (P<0.05). +lncRNA target 34762771 hsa-mir-29c gastric adenocarcinoma CONCLUSION: This finding confirmed that lncRNA TUG1 acts as a ceRNA for miR-29c-3p to promote tumor progression and angiogenesis by upregulating VEGFA, indicating TUG1 as a therapeutic target in STAD management. +circRNA target 34762494 hsa-mir-548m Glioma Conclusions: All these results demonstrate that circ-GLIS3 accelerates TMZ-R glioma progression through the miR-548m/MED31 axis. +other 34762068 hsa-mir-2052 Breast Neoplasms BACKGROUND: Published studies based on pharmacokinetics have explored the relationship between the lncRNA MIR2052HG and the prognosis of breast cancer (BC) resistance and recurrence. +genetics_GWAS 34762068 hsa-mir-4456 Breast Neoplasms CONCLUSION: Our study showed that the MIR2052HG gene polymorphism may be related to BC susceptibility, and the MIR2052HG rs34841297 A/- genotype may probably affect the proliferation, invasion and migration of BC cells by modulating the interactions with of miR-4456. +genetics_GWAS 34761964 hsa-mir-938 Hirschsprung Disease Aim: To explore the association between miR-938rs2505901 T>C polymorphism and Hirschsprung disease (HSCR) risk in Chinese children. Conclusion: Our study indicated that miR-938rs2505901 T>C polymorphism is significantly associated with HSCR risk in Chinese children. +other 34761722 hsa-mir-30 psoriasis 1 There was a negative correlation between miR5p and MALAT-1 (or S100A7) expression in psoriatic lesion tissues. +lncRNA target 34761662 hsa-mir-224 Rhinitis, Allergic It proves that miR-224 could be a novel potential therapeutic target for AR. +genetics_overexpression_suppress 34761629 hsa-mir-204 Pancreatic Carcinoma Overexpression of microRNA +circulation_biomarker_prognosis_ns 34761617 hsa-mir-410 Carcinoma, Renal Cell MiR-410 in the tissues and serum of patients with CCRCC was quantified, and the diagnostic value of miR-410 in CCRCC and the relationship between miR-410 and prognosis of patients with CCRCC were analyzed. +lncRNA target 34761614 hsa-mir-188 Lymphoma, Natural Killer/T-Cell 5p suppressed tumor progression in NKTCL by regulating XRCC5. +lncRNA target 34761606 hsa-mir-217 Carcinoma, Hepatocellular CONCLUSIONS: LINC00355 is upregulated in HCC specimens, LINC00355 triggers proliferative rate and inhibits apoptosis in HCC cells by negatively regulating miR5p and activating the Wnt/beta-catenin signaling. +genetics_knock down_promote 34761592 hsa-mir-138 Carcinoma, Non-Small-Cell Lung CONCLUSION: Circ-PRMT5 knockdown increased DDP sensitivity and immune response of NSCLC cells by regulating miR +exosome 34761590 hsa-mir-126 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: Taken together, the key finding of the study indicated that over-expressed BMSCs-derived exosomal miR +genetics_overexpression_promote 34761583 hsa-mir-99a Uterine Cervical Neoplasms To further verify the correlation of miR-99a with IGF1R in cervical cancer, we co-transfected miR-99a and IGF1R overexpression vectors into the cells and found that compared with CCCs transfected with miR-99a overexpression vectors alone, the expression of IGF1R in the co-transfection group increased, while the expression of miR-99a did not change significantly. +genetics_overexpression_promote 34761581 hsa-mir-34a Uterine Cervical Neoplasms Co-transfection assays showed that overexpression of CDC25A reversed the inhibition of miR-34a-5p on CC growth and migration. +lncRNA target 34761351 hsa-mir-383 Breast Neoplasms 5p restoration, as a tumor-suppressive miR, with taxol therapy in suppressing MDA-MB-231 breast cancer development. +other 34761332 hsa-mir-223 Brain Injuries, Traumatic 3p and other inflammatory responsive miRNAs may play a key role in sex-specific neuroinflammatory response following TBI. +transcription factor target 34761190 hsa-mir-1307 Liver Neoplasms miR-1307 is highly expressed in liver cancer and inhibits methyltransferase protein8. +lncRNA target 34761116 hsa-mir-141 Mesothelioma, Malignant MALAT1 can be used as a competitive endogenous RNA (ceRNA) to regulate the YAP1-Hippo signaling pathway through miR +genetics_overexpression_suppress 34761115 hsa-mir-150 Angelman Syndrome 5p weakened the ox-LDL-induced increase of viability and migration abilities and blocked cell cycle in ASMCs, but overexpressed STAT1 blocked the effect of the miR +transcription factor target 34761108 hsa-mir-378a Glioma This study confirmed that miR-378a-3p promoted the sensitivity of glioma cells to CDDP in glioma patients via targeting IGF1R to increase the therapeutic effect during chemotherapy. +other 34761005 hsa-mir-27a Retinal Detachment Also, our data emphasize the prominent role of miR-27a/FOXO1 axis in modulating ROS accumulation and cell death in RPE cell model under oxidative stress and influencing the retinal function in the LED-induced RD rat model. +circulation_biomarker_diagnosis_up 34760951 hsa-mir-92a Refractory Angina Circulating miR-92a increased significantly in ECP [5.1 (4.2-6.4) to 5.9 (4.8-6.4), p < 0.001] and sham [5.2 (4.1-9.4) to 5.6 (4.8-6.3), p = 0.008] post-intervention. +other 34760693 hsa-mir-182 Carcinoma, Renal Cell 5p, and PAX3. +other 34760693 hsa-mir-182 von Hippel-Lindau Disease 5p, and PAX3. +other 34760693 hsa-mir-183 Carcinoma, Renal Cell 5p, and PAX3. +other 34760693 hsa-mir-183 von Hippel-Lindau Disease 5p, and PAX3. +other 34760337 hsa-mir-520h Prostatic Neoplasms HnRNP-L-regulated circCSPP1/miR-520h/EGR1 axis modulates autophagy and promotes progression in prostate cancer. +other 34759745 hsa-mir-378 Ovarian Neoplasms CircRNA PLOD2 enhances ovarian cancer propagation by controlling miR-378. +other 34759299 hsa-mir-7 Mitochondrial Diseases Consistently, electron microscopy showed that miRNA-7 Tg hearts had disorganized rounded mitochondria that was associated with mitochondrial dysfunction. +other 34759299 hsa-mir-7 Dmd-Associated Dilated Cardiomyopathy These findings show that expression of miRNA-7 in the cardiomyocytes results in cardiac dilation instead of adaptive hypertrophic response during aging or to TAC providing insights on yet to be understood role of miRNA-7 in cardiac function. +circulation_biomarker_diagnosis_up 34758804 hsa-mir-155 Pneumonia METHODS: GAS5 and miR-155 levels in plasma samples from pneumonia patients and controls were detected using RT-qPCR. +lncRNA target 34758714 hsa-mir-4295 Stomach Neoplasms Our study suggested that miR-4295 might be a potential therapeutic target for gastric cancer. +circRNA target 34758534 hsa-mir-873 Thyroid Neoplasms Conclusion: circ_0023990 was highly expressed in thyroid cancer tissues and cell lines, and it may promote the radiotherapy resistance of thyroid cancer cells in vivo through regulating miR +genetics_overexpression_suppress 34758406 hsa-mir-4732 Carcinoma, Non-Small-Cell Lung In addition, the overexpression of miR +other 34758342 hsa-mir-21 Neuralgia Patient biomaterial revealed different systemic expression patterns of miR5p, with higher expression in SFN and lower expression in NL. +lncRNA target 34758237 hsa-mir-125b Precursor Cell Lymphoblastic Leukemia-Lymphoma METHODS: Real-time fluorescent quantitative PCR was utilized to test circPVT1 and miR-125b in ALL samples and ALL cell systems. CONCLUSIONS: CircPVT2 can promote ALL cell proliferation and invading through miR-125b modulation of NF-kappaB, which would be one new potential target for ALL therapy. +genetics_overexpression_promote 34758200 hsa-mir-107 Glioma Overexpression of miR-107 reduced proliferation, migration and invasion, and augmented apoptosis of glioma cells, and it reduced activity of the Wnt/beta-catenin pathway. +lncRNA target 34757838 hsa-mir-376b Porcine Reproductive and Respiratory Syndrome In the present study, we demonstrated that a host microRNA, miR-376b-3p, was upregulated by PRRSV infection through the viral components, nsp4 and nsp11, and that miR-376b-3p can directly target tripartite motif-containing 22 (TRIM22) to impair its anti-PRRSV activity, thus facilitating the replication of PRRSV. +other 34757596 hsa-mir-539 Cardiomyopathies METHODS: The model of septic cardiomyopathy was constructed with H9c2 cells induced by lipopolysaccharide (LPS), and the expression of miR5p was detected by qRT-PCR assay. +transcription factor target 34757596 hsa-mir-539 Sepsis 5p may be a potential new target for the treatment of LPS-induced sepsis. +lncRNA target 34756071 hsa-mir-22 Encephalitis, Japanese Japanese encephalitis virus (JEV) NS1', a larger NS1-related protein, is known to inhibit the mitochondrial antiviral signaling (MAVS)-mediated IFN-beta induction by increasing the binding of transcription factors (CREB and c-Rel) to the microRNA 22 (miRNA-22) promoter. +lncRNA target 34756016 hsa-mir-155 Acute Lung Injury We report here a unique design of a functional nanoplatform based on generation 5 (G5) poly(amidoamine) dendrimer-entrapped gold nanoparticles (Au DENPs) to co-deliver dexamethasone (Dex) and a microRNA-155 inhibitor (miR-155i) for combination chemotherapy and gene therapy of ALI. The integration of Dex and miR-155i within one nanoformulation enables superior downregulation of pro-inflammatory cytokines for successful repair of damaged lung tissues in an ALI model, as demonstrated by histological examinations and pro-inflammatory cytokine downregulation in ALI lesion at the gene and protein levels. +other 34755842 hsa-mir-133a COVID-19 Whilst RNAemia, age and troponin were better predictors of mortality, miR-133a and miR-122 showed superior classification performance for severity. +other 34755842 hsa-mir-122 COVID-19 Whilst RNAemia, age and troponin were better predictors of mortality, miR-133a and miR-122 showed superior classification performance for severity. +genetics_overexpression_promote 34755673 hsa-mir-671 Osteosarcoma 5p overexpression obviously reversed this effect (P < 0.05). +other 34755560 hsa-mir-130b Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: DHA can block ILtriggered EMT and invasion in LSCC, and during these processes, DHA increases miR-130b-3p expression to decrease the activation of the IL-6/STAT3 and beta-catenin signaling pathways. +genetics_knock down_promote 34755307 hsa-mir-132 Urinary Bladder Neoplasms 3p or KCNJ12 knockdown. +other 34755149 hsa-mir-19a Neuralgia Both hsa-miR-19a-3p and hsa-miR-19b-3p levels were significantly higher in those with chronic SCI and severe neuropathic pain versus those with chronic SCI and no neuropathic pain. +other 34755149 hsa-mir-19b Spinal Cord Injuries Both hsa-miR-19a-3p and hsa-miR-19b-3p levels were significantly higher in those with chronic SCI and severe neuropathic pain versus those with chronic SCI and no neuropathic pain. +other 34755149 hsa-mir-19 Neuralgia We selected homo sapiens (hsa)-miR-19a-3p and hsa-miR-19b-3p for additional analysis based on p-value, fold change, and their known role as regulators of neuropathic pain and neuroinflammation. Both hsa-miR-19a-3p and hsa-miR-19b-3p levels were significantly higher in those with chronic SCI and severe neuropathic pain versus those with chronic SCI and no neuropathic pain. +other 34755149 hsa-mir-19b Neuralgia Both hsa-miR-19a-3p and hsa-miR-19b-3p levels were significantly higher in those with chronic SCI and severe neuropathic pain versus those with chronic SCI and no neuropathic pain. +other 34755149 hsa-mir-19 Spinal Cord Injuries We selected homo sapiens (hsa)-miR-19a-3p and hsa-miR-19b-3p for additional analysis based on p-value, fold change, and their known role as regulators of neuropathic pain and neuroinflammation. Both hsa-miR-19a-3p and hsa-miR-19b-3p levels were significantly higher in those with chronic SCI and severe neuropathic pain versus those with chronic SCI and no neuropathic pain. +other 34755149 hsa-mir-19a Spinal Cord Injuries Both hsa-miR-19a-3p and hsa-miR-19b-3p levels were significantly higher in those with chronic SCI and severe neuropathic pain versus those with chronic SCI and no neuropathic pain. +circRNA target 34754888 hsa-mir-496 Osteoporosis CONCLUSION: Our study demonstrated that RUNX3 promoted osteogenic differentiation via regulating the hsa_circ_0005752/miR-496/MDM2 axis and thus provided a new therapeutic strategy for osteoporosis. +other 34754625 hsa-mir-155 Reperfusion Injury, Renal Ischemia Fosl2-miR-155, Fosl2-miR-146a, Cebpb-miR-155 and Mafk-miR-25 might be the negative feedback loops in renal IRI. +other 34754625 hsa-mir-146a Reperfusion Injury, Renal Ischemia Fosl2-miR-155, Fosl2-miR-146a, Cebpb-miR-155 and Mafk-miR-25 might be the negative feedback loops in renal IRI. +other 34754625 hsa-mir-25 Reperfusion Injury, Renal Ischemia Fosl2-miR-155, Fosl2-miR-146a, Cebpb-miR-155 and Mafk-miR-25 might be the negative feedback loops in renal IRI. +other 34754623 hsa-mir-708 Lung Neoplasms The good screening capability and reliability of miR5p as a lung cancer marker were confirmed by AUC values and gene expression profiling of external datasets, and experimental literature. +other 34754230 hsa-mir-23a Pre-Eclampsia LncRNA (LINCO2532 and SLCO4A1-AS1) and DYNLRB1 were downregulated and the expression of miR23a-5p was upregulated in PE patients compared with healthy controls. +transcription factor target 34754027 hsa-mir-7515 Sarcoma, Ewing Interestingly, SCE cells treated with miR-7515 mimic showed increased VEGFA, VEGFR2, PECAM, and Tie2 expression. Our data showed that TM cells may communicate with SCE cells via exomiRs and that miR-7515 may be important for SCE cell reprogramming. +lncRNA target 34753831 hsa-mir-214 Arthritis, Rheumatoid In summary, our study shows that tocilizumab suppresses RA-FLS inflammation by regulating the MIR31HG-miR +lncRNA target 34753831 hsa-mir-1 Arthritis, Rheumatoid In summary, our study shows that tocilizumab suppresses RA-FLS inflammation by regulating the MIR31HG-miR +genetics_knock down_suppress 34753799 hsa-mir-200c Diabetes Mellitus, Type 2 Finally, LNA knockdown of miR-200c increased glucose-stimulated insulin secretion in islets from T2D donors approximately threefold. +genetics_knock down_suppress 34753799 hsa-mir-200 Diabetes Mellitus, Type 2 Finally, LNA knockdown of miR-200c increased glucose-stimulated insulin secretion in islets from T2D donors approximately threefold. +other 34753773 hsa-mir-122 Colorectal Neoplasms Across multiple colorectal cancer liver metastasis models, treatment with Gal-LCP miR-122 treatment effectively prevented colorectal cancer liver metastasis and prolonged survival. +lncRNA target 34753486 hsa-mir-934 Carcinoma, Non-Small-Cell Lung Furthermore, circUSP7 inhibits CD8(+) T cell function by upregulating the expression of Src homology region 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2) via sponging miR-934. +circRNA target 34753401 hsa-mir-193b Precursor T-Cell Lymphoblastic Leukemia-Lymphoma CONCLUSION: Our findings proposed a novel model in which circ_0000745 promoted cell proliferation and curbed cell apoptosis via upregulating NOTCH1 through serving as a miR-193b-3p sponge in T-ALL. +circRNA target 34753398 hsa-mir-497 Norrie disease 5p/NFAT5 axis in HK-2 cells in vitro, providing a possible therapy target for DN. +lncRNA target 34753396 hsa-mir-150 Colorectal Neoplasms We further demonstrated that the effects of LINC00857 in CRC cells were mediated through miR +genetics_knock down_promote 34753394 hsa-mir-22 Osteosarcoma 3p on OS progression and promotion of Wnt/beta-catenin were reversed by simultaneous knockdown of TCF7L2. +circulation_biomarker_diagnosis_ns 34753389 hsa-mir-223 Fractures, Bone The research explored the level of serum miR +other 34753389 hsa-mir-223 Radius Fractures 3p was significantly elevated over time in patients with intra-articular fracture and hand fracture compared with healthy individuals. +other 34753389 hsa-mir-223 Intra-Articular Fractures 3p was significantly elevated over time in patients with intra-articular fracture and hand fracture compared with healthy individuals. +lncRNA target 34753384 hsa-mir-381 Colorectal Neoplasms In summary, our data revealed that the miR-381/SPIN1 axis greatly contributes to CRC tumorigenesis by orchestrating the Wnt/beta-catenin pathway, thereby representing actionable therapeutic targets for colorectal cancer patients. +genetics_overexpression_promote 34753136 hsa-mir-1 Osteoarthritis Further functional experiments demonstrated that overexpressing miR +genetics_overexpression_promote 34753133 hsa-mir-142 Colonic Neoplasms Overexpressing miR +other 34753061 hsa-mir-155 Urinary Bladder Neoplasms 5p/WEE1 axis in GEM resistant BC cells, providing a novel therapeutic strategy for BC. +target gene 34752967 hsa-mir-205 Carcinoma, Non-Small-Cell Lung He-Chan Pian inhibits the metastasis of non-small cell lung cancer via the miR-205-5p-mediated regulation of the GREM1/Rap1 signaling pathway. +circulation_biomarker_prognosis_up 34752733 hsa-mir-222 Breast Neoplasms The receiver operating characteristic curves plotted for serum p27 and miR-222 helped in significantly differentiating between breast cancer patients and controls but could not discriminate between those with stage II and stage III cancer. +lncRNA target 34751998 hsa-mir-125a Developmental Disabilities Mechanistically, we confirmed that miR-125a-5p disturbed the mitochondrial function by targeting Rbm38 and activating the p53 damage response pathway, and induced a developmental delay in a p21-dependent manner. +other 34751973 hsa-mir-488 Spinal Cord Injuries Our research provides a better understanding of the mechanism of circPrkcsh in SCI and demonstrates that the circPrkcsh/miR-488/Mekk1 axis is a promising regulatory method for the treatment of SCI. +genetics_GWAS 34751841 hsa-mir-200a Stomach Neoplasms Although ontogenetic or tumor-suppressive effects of miRNA-200a-3p have been demonstrated, the exact mechanism underlying GC is not clear. +other 34751517 hsa-mir-4516 Triple Negative Breast Neoplasms RESULTS: miR-718, miR-4516, miR-210, and miR-125b-5p were found to be specific miRNAs associated with chemo-sensitivity of luminal B HER2 negative patients (n = 24). +other 34751517 hsa-mir-125b Triple Negative Breast Neoplasms RESULTS: miR-718, miR-4516, miR-210, and miR-125b-5p were found to be specific miRNAs associated with chemo-sensitivity of luminal B HER2 negative patients (n = 24). +other 34751517 hsa-mir-210 Triple Negative Breast Neoplasms RESULTS: miR-718, miR-4516, miR-210, and miR-125b-5p were found to be specific miRNAs associated with chemo-sensitivity of luminal B HER2 negative patients (n = 24). +other 34751517 hsa-mir-718 Triple Negative Breast Neoplasms RESULTS: miR-718, miR-4516, miR-210, and miR-125b-5p were found to be specific miRNAs associated with chemo-sensitivity of luminal B HER2 negative patients (n = 24). +lncRNA target 34751414 hsa-mir-34a Cataract, Diabetic In conclusion, XIST promoted cell proliferation, migration and invasion, and inhibited apoptosis, through the miR34a/SMAD2 axis in DC. +lncRNA target 34751282 hsa-mir-21 Carcinoma, Non-Small-Cell Lung As the concept of design, chitosan-derived nanocarrier DCAFP, capable of persuading mitochondrial dysfunction, is demonstrated to convey gefitinib (GFT) and miR21 inhibitor (anti-miR21) to form DGA nanoparticles. +transcription factor target 34751119 hsa-mir-582 Parkinson Disease CONCLUSION: Our results indicated that miR5p ameliorates neuronal injury by inhibiting apoptosis, inflammation, and oxidative stress through targeting HMGB1. +transcription factor target 34751119 hsa-mir-582 Hypoxia-Ischemia, Brain CONCLUSION: Our results indicated that miR5p ameliorates neuronal injury by inhibiting apoptosis, inflammation, and oxidative stress through targeting HMGB1. +genetics_overexpression_promote 34751080 hsa-mir-29a Osteoarthritis RESULTS: CircCTNNA1 was downregulated in OA, while miR-29a was overexpressed in OA. CONCLUSIONS: CircCTNNA1 is downregulated in OA, and its overexpression suppresses synoviocyte apoptosis via sponging miR-29a. +transcription factor target 34750830 hsa-mir-630 Atherosclerosis In addition, miR-630 can also target EZH2 to modulate the transcription of TIMP2 and to influence the migration of MASMCs. +genetics_knock down_promote 34750680 hsa-mir-9 Optic atrophy 1 and deafness 5p knockdown promotes HG-induced osteogenic differentiation BMSCs in vitro and mitigates the DOP condition of rats in vivo by targeting DDX17. +exosome 34750610 hsa-mir-150 Acute Lung Injury CONCLUSIONS: Exosomal miR-150 attenuates lipopolysaccharide-induced ALI through the MAPK pathway. +other 34750486 hsa-mir-16 COVID-19 Moreover, ten miRNAs including miR-193b, miR-192, miR-215, miR-34a, miR-16, miR-16, miR-92a, miR-30a, miR-7, and miR-26b were found to be significant miRNAs in treating SARS-CoV-2 coronavirus. +other 34750486 hsa-mir-193b COVID-19 Moreover, ten miRNAs including miR-193b, miR-192, miR-215, miR-34a, miR-16, miR-16, miR-92a, miR-30a, miR-7, and miR-26b were found to be significant miRNAs in treating SARS-CoV-2 coronavirus. +other 34750486 hsa-mir-34a COVID-19 Moreover, ten miRNAs including miR-193b, miR-192, miR-215, miR-34a, miR-16, miR-16, miR-92a, miR-30a, miR-7, and miR-26b were found to be significant miRNAs in treating SARS-CoV-2 coronavirus. +other 34750486 hsa-mir-192 COVID-19 Moreover, ten miRNAs including miR-193b, miR-192, miR-215, miR-34a, miR-16, miR-16, miR-92a, miR-30a, miR-7, and miR-26b were found to be significant miRNAs in treating SARS-CoV-2 coronavirus. +other 34750486 hsa-mir-7 COVID-19 Moreover, ten miRNAs including miR-193b, miR-192, miR-215, miR-34a, miR-16, miR-16, miR-92a, miR-30a, miR-7, and miR-26b were found to be significant miRNAs in treating SARS-CoV-2 coronavirus. +other 34750486 hsa-mir-26b COVID-19 Moreover, ten miRNAs including miR-193b, miR-192, miR-215, miR-34a, miR-16, miR-16, miR-92a, miR-30a, miR-7, and miR-26b were found to be significant miRNAs in treating SARS-CoV-2 coronavirus. +other 34750486 hsa-mir-215 COVID-19 Moreover, ten miRNAs including miR-193b, miR-192, miR-215, miR-34a, miR-16, miR-16, miR-92a, miR-30a, miR-7, and miR-26b were found to be significant miRNAs in treating SARS-CoV-2 coronavirus. +other 34750486 hsa-mir-92a COVID-19 Moreover, ten miRNAs including miR-193b, miR-192, miR-215, miR-34a, miR-16, miR-16, miR-92a, miR-30a, miR-7, and miR-26b were found to be significant miRNAs in treating SARS-CoV-2 coronavirus. +other 34750395 hsa-mir-571 Liver Cirrhosis miR-571, Notch3 and Jagged1 are up-regulated in patients with liver fibrosis and is associated with the progression of liver fibrosis. +genetics_overexpression_promote 34750354 hsa-mir-543 Lymphoma, B-Cell BTKi-resistant CLL and DLBCL cells had striking overexpression of miR-494, miR-495, miR-543, and reduced PTEN expression, indicating further regulation of the PI3K/AKT/mTOR pathway in acquired BTKi resistance. Additionally, unlike ibrutinib-sensitive CLL patient samples, those with resistance to ibrutinib treatment, demonstrated upregulation of 14q32 cluster miRNAs, including miR-494, miR-495, and miR-543 and decreased pten mRNA expression. +genetics_overexpression_promote 34750354 hsa-mir-494 Lymphoma, B-Cell BTKi-resistant CLL and DLBCL cells had striking overexpression of miR-494, miR-495, miR-543, and reduced PTEN expression, indicating further regulation of the PI3K/AKT/mTOR pathway in acquired BTKi resistance. Additionally, unlike ibrutinib-sensitive CLL patient samples, those with resistance to ibrutinib treatment, demonstrated upregulation of 14q32 cluster miRNAs, including miR-494, miR-495, and miR-543 and decreased pten mRNA expression. +genetics_overexpression_promote 34750354 hsa-mir-495 Lymphoma, B-Cell BTKi-resistant CLL and DLBCL cells had striking overexpression of miR-494, miR-495, miR-543, and reduced PTEN expression, indicating further regulation of the PI3K/AKT/mTOR pathway in acquired BTKi resistance. Additionally, unlike ibrutinib-sensitive CLL patient samples, those with resistance to ibrutinib treatment, demonstrated upregulation of 14q32 cluster miRNAs, including miR-494, miR-495, and miR-543 and decreased pten mRNA expression. +lncRNA target 34750351 hsa-mir-185 Squamous Cell Carcinoma of Head and Neck In conclusion, our findings firstly confirmed the carcinogenic effect of circ_0058106 in promoting HSCC cells tumorigenesis, metastasis, invasion and EMT process by regulating Wnt2b/-catenin/c-Myc pathway through sponging miR +lncRNA target 34749775 hsa-mir-378a Carcinoma, Hepatocellular CONCLUSION: Our study indicates a novel DNMT1/miR-378a-3p/TRAF1/NF-kappaB positive feedback loop in HCC cells, which may become a potential therapeutic target for HCC. +other 34749766 hsa-mir-7161 Stomach Neoplasms 3p-mediated translational repression of SPZ1, thus contributing to gastric cancer progression. +genetics_overexpression_suppress 34749662 hsa-mir-216a Asthma RESULTS: TUG1 and SMURF2 were overexpressed and miR-216a-3p was downregulated in childhood asthma patients and PDGF-BB-stimulated HASMCs. CONCLUSION: TUG1 downregulation inhibited PDGF-BB-induced HASMC proliferation and migration by regulating miR-216a-3p/SMURF2 axis, offering novel insight into the potential application of TUG1 for childhood asthma treatment. +transcription factor target 34749575 hsa-mir-26a Liver Injury BACKGROUNDS: miR-26a-5p is a short noncoding RNA that is abnormally expressed in drug-induced liver injury (DILI), but its pathophysiologic role in the mechanism of disease in DILI is still vague. CONCLUSIONS: miR-26a-5p played a protective role against DILI via targeting Bid. +lncRNA target 34749521 hsa-mir-4521 Stomach Neoplasms MiR-4521 inhibition or PIK3R3 over-expression weakened the anti-cancer functions of sulforaphane in gastric carcinoma cells. +circulation_biomarker_diagnosis_up 34749366 hsa-mir-381 Inflammation 3p is less expressed in the serum of AD patients and has potential diagnostic values for AD. +circulation_biomarker_diagnosis_up 34749366 hsa-mir-381 Alzheimer Disease 3p is less expressed in the serum of AD patients and has potential diagnostic values for AD. +circulation_biomarker_diagnosis_up 34749366 hsa-mir-381 Neurotoxicity Syndromes 3p is less expressed in the serum of AD patients and has potential diagnostic values for AD. +lncRNA target 34749249 hsa-mir-218 Myocardial Reperfusion Injury 5p choked oxidative stress and inflammation in myocardial I/R injury via targeting MEF2C/NF-kappaB axis, thus relieving the disease progression. +other 34748956 hsa-mir-146a Diabetes Mellitus In this study, we define the mechanism(s) by which CNP-miR146a improves diabetic wound healing by examining immunohistochemical and gene expression analysis of markers of inflammation, oxidative stress, fibrosis, and angiogenesis. +transcription factor target 34748611 hsa-mir-155 Arthritis, Rheumatoid "Consistent with this, ES-62 ""rewiring"" of SFs away from the hyper-responsive phenotype is associated with suppression of ERK activation, STAT3 activation and miR-155 upregulation, signals widely associated with SF pathogenesis." +genetics_overexpression_promote 34748526 hsa-mir-345 Adenocarcinoma of Lung Rescue assays revealed that overexpression of RhoA rescued the suppressive effects of miR +transcription factor target 34748368 hsa-mir-101a Inflammation Upregulated miR1 and miR-101a inhibited LPS-induced inflammatory cytokine production by targeting tumor necrosis factor receptor-associated factor 6 (TRAF6), thus avoiding excessive inflammation. +lncRNA target 34747666 hsa-mir-495 Esophageal Neoplasms Conclusions: MiR-495 suppressed cisplatin resistance and angiogenesis in esophageal cancer cells by targeting ATP7A gene expression. +transcription factor target 34747545 hsa-mir-122 Alopecia These findings suggested that upregulation of miR-122 induces apoptosis, potentially via the repression of IGF1R in hDPCs of AGA, providing a novel insight into the potential pathological mechanism of miR-122 in AGA DPCs. +other 34747544 hsa-mir-200c familial multiple nevi flammei Our findings suggest that the significant downregulation of miR-200c/429 in CMCs maintains the expression of N-Cadherin, which may be important for its functional integrity. +other 34747544 hsa-mir-429 familial multiple nevi flammei We found significant downregulation of miR-200c and miR-429 in CMCs. Our findings suggest that the significant downregulation of miR-200c/429 in CMCs maintains the expression of N-Cadherin, which may be important for its functional integrity. +transcription factor target 34747314 hsa-mir-138 Breast Neoplasms miR-138 targeted regulation of SEMA4C can promote the expression of N-cad, inhibit the expression of E-cad, vim and SEMA4C, reverse the EMT of BC cells, and inhibit the activity and invasion of BC cells. +other 34747300 hsa-mir-758 Carcinoma, Non-Small-Cell Lung 3p, thereby promoting NSCLC progression. +other 34747300 hsa-mir-145 Carcinoma, Non-Small-Cell Lung 3p, thereby promoting NSCLC progression. +other 34747300 hsa-mir-585 Carcinoma, Non-Small-Cell Lung 3p, thereby promoting NSCLC progression. +transcription factor target 34747081 hsa-mir-181b Pre-Eclampsia At molecular level, the expression level of miR-181b-5p was both induced in vivo and in vitro with the development of PE symptoms, contributing to the inhibited expression of RBAK. The induced expression of miR-181b-5p under Pue treatment showed that the re-induction of miR-181b-5p counteracted the effects of Pue, indicating the key role of the miR in the protective effects of Pue against PE. +transcription factor target 34747081 hsa-mir-181b Inflammation At molecular level, the expression level of miR-181b-5p was both induced in vivo and in vitro with the development of PE symptoms, contributing to the inhibited expression of RBAK. The induced expression of miR-181b-5p under Pue treatment showed that the re-induction of miR-181b-5p counteracted the effects of Pue, indicating the key role of the miR in the protective effects of Pue against PE. +lncRNA target 34746996 hsa-mir-146b Pituitary Neoplasms CONCLUSIONS: MiRNA-146b-5p can inhibit EPHA7 expression, suppress the IRAK4/TRAF6/NF-kappaB signaling pathway, and weaken PA cell invasion, metastasis, proliferation, and TMZ-induced chemoresistance in vitro. +exosome 34746322 hsa-mir-126 Hepatoblastoma CONCLUSIONS: Exosomal miR-126 derived from hepatoblastoma cells promoted the tumorigenesis of liver cancer through inducing the differentiation of BMSCs into cancer stem cells. +genetics_overexpression_suppress 34746238 hsa-mir-142 Leukemia, Myeloid, Acute 3P have a negative correlation with DUBR and overexpression of miRNA +other 34746237 hsa-mir-182 Autism Spectrum Disorder 5p/S100A2. +other 34746237 hsa-mir-221 Autism Spectrum Disorder 5p/S100A2. +other 34746237 hsa-mir-132 Autism Spectrum Disorder 5p/S100A2. +lncRNA target 34746123 hsa-mir-503 Bone Diseases Thus, the present study demonstrated that the lncRNAs LOC100126784 and POM121L9P facilitate the osteogenic differentiation of BMSCs via the miR5p/SORBS1 axis, providing potential therapeutic targets for treating osteoporosis and bone defects. +lncRNA target 34746123 hsa-mir-503 Osteoporosis Thus, the present study demonstrated that the lncRNAs LOC100126784 and POM121L9P facilitate the osteogenic differentiation of BMSCs via the miR5p/SORBS1 axis, providing potential therapeutic targets for treating osteoporosis and bone defects. +other 34746118 hsa-mir-190a Stomach Neoplasms The results of bioinformatics analysis showed that the expression of NR2F1-AS1/miR-190a/PHLDB2 in GC was positively associated with the pathological features, staging, poor prognosis, and EMT process. Thus, our results showed that NR2F1-AS1/miR-190a/PHLDB2 promoted the phosphorylation of AKT3 to induce EMT in GC cells. +target gene 34746018 hsa-mir-206 Uterine Cervical Neoplasms LncRNA OTUD6B-AS1 Induces Cisplatin Resistance in Cervical Cancer Cells Through Up-Regulating Cyclin D2 via miR-206. +transcription factor target 34745992 hsa-mir-122 Carcinoma, Hepatocellular Together, these findings suggest that AR could suppress HCC invasion and migration capacities via miR +target gene 34745940 hsa-mir-125b Breast Neoplasms LncRNA LGALS8-AS1 Promotes Breast Cancer Metastasis Through miR-125b-5p/SOX12 Feedback Regulatory Network. +other 34745937 hsa-mir-223 Stomach Neoplasms Long Noncoding RNA KLF3-AS1 Acts as an Endogenous RNA of miR-223 to Attenuate Gastric Cancer Progression and Chemoresistance. +target gene 34745557 hsa-mir-1 Colorectal Neoplasms Propofol regulates miR-1-3p/IGF1 axis to inhibit the proliferation and accelerates apoptosis of colorectal cancer cells. +lncRNA target 34745428 hsa-mir-25 Myocardial Infarction Collectively, M1-BMMs-EVs inhibited angiogenesis and myocardial regeneration following MI via the MALAT1/miR +lncRNA target 34745323 hsa-mir-19a Urinary Bladder Neoplasms CONCLUSION: miR-19a-3p facilitates cell progression in BLCA via binding THBS1, which may be an underlying therapeutic target for BLCA treatment. +lncRNA target 34745257 hsa-mir-96 Thyroid Cancer, Papillary 5p/PKN2 axis was closely related to the progression of PTC, which could be a potential target for treating PTC patients. +transcription factor target 34745206 hsa-mir-139 autosomal recessive congenital bilateral absence of vas deferens In conclusion, these results suggest that miR5p plays an important role in osteogenic differentiation of VICs via the Wnt/beta-Catenin pathway, which may further provide a new therapeutic target for CAVD. +lncRNA target 34745118 hsa-mir-127 Lupus Nephritis 3p contributes to the overactivation of IFN-I signaling pathway in the kidneys of LN patients through promoting the expression of JAK1, suggesting hsa-miR +other 34744440 hsa-mir-197 Asthma 3p, miR-193a-5p, miR-1246, and miR-92b-3p). +other 34744440 hsa-mir-92b Asthma 3p, miR-193a-5p, miR-1246, and miR-92b-3p). +other 34744440 hsa-mir-193a Asthma 3p, miR-193a-5p, miR-1246, and miR-92b-3p). +other 34744440 hsa-mir-124 Asthma 3p, miR-193a-5p, miR-1246, and miR-92b-3p). +transcription factor target 34744440 hsa-mir-1246 Asthma The most promising causal miRNA candidate, miR-1246, was examined in an in vitro system to explore its targets and roles in asthma pathophysiology. Strikingly, among all screened miRNAs, miR-1246, which could interact with POSTN may have multifunctional effects in the course of asthma and be a promising agent for asthma treatment and molecular subtyping. +transcription factor target 34744059 hsa-mir-214 Femur Head Necrosis CONCLUSIONS: miR-214 participates in the inhibition of osteoblastic bone formation, and the inhibition of miR-214 to bone formation during transplantation therapy with Bio-Oss combined with BMSCs for ONFH. +lncRNA target 34743973 hsa-mir-182 Splenic Diseases Therefore, CAPE could be a food-derived spleen protector to counteract Cd-induced spleen toxicity through alleviating apoptosis and inflammation via the miR5p/TLR4/NF-kappaB axis. +lncRNA target 34743948 hsa-mir-182 Depression CONCLUSIONS: The results suggested that activation of NF-kappaB inhibited GPR39/CREB/BDNF pathway through increasing miR-182 in chronic stress-induced depressive-like behaviors. +transcription factor target 34743685 hsa-mir-16 Breast Neoplasms 5p and knock-down of ANLN remarkably inhibited cell proliferation and migration as well as cell invasion, arrested the cells in G2/M phase and induced apoptosis in BC cells. +other 34743291 hsa-mir-155 ankylosing spondylitis 1 Furthermore, miR-146a, miR-125a-5p, miR-125b-5p, miR-499a, and miR-155a could have potential diagnostic value in AS. +other 34743291 hsa-mir-125a ankylosing spondylitis 1 Furthermore, miR-146a, miR-125a-5p, miR-125b-5p, miR-499a, and miR-155a could have potential diagnostic value in AS. +epigenetics 34743198 hsa-mir-124-2 Muscular Dystrophy, Duchenne METHODS: This study evaluated the discriminative power of FAM19A4/miR124-2 methylation, HPV16/18 genotyping and HPV16/18/31/33/45 genotyping in HPV-positive women with BMD (n = 294) in two Dutch screening trials. CONCLUSION: The use of FAM19A4/miR124-2 methylation and/or HPV genotyping in HPV-positive women with BMD can lead to a substantial reduction in the number of direct colposcopy referrals. +transcription factor target 34743197 hsa-mir-9 Sepsis This study also highlights the proinflammatory mechanism associated with miR5p-mediated inhibition of SIRT1, which contributes to a more comprehensive understanding of the pathogenesis of sepsis. +target gene 34742920 hsa-mir-183 Liver Neoplasms ABAT targeted by miR-183-5p regulates cell functions in liver cancer. +genetics_overexpression_promote 34742738 hsa-mir-140 Asthma Finally, rescue assays demonstrated that GSK3beta overexpression rescued the effects of miR-140 on asthma progression. +genetics_overexpression_promote 34742738 hsa-mir-140 Airway Inflammation Finally, rescue assays demonstrated that GSK3beta overexpression rescued the effects of miR-140 on asthma progression. +circulation_biomarker_diagnosis_up 34742341 hsa-mir-146a Atherosclerosis CONCLUSION: Therefore, SCIRT is downregulated in atherosclerosis and it suppresses the proliferation of HAOSMCs by sponging miR-146a in cytoplasm. +circRNA target 34742305 hsa-mir-1224 Colorectal Neoplasms 5p inhibitor. +circulation_biomarker_diagnosis_up 34742256 hsa-mir-214 Norrie disease RESULTS: Results from the experiments manifested up-regulated levels of NNT-AS1 and smad4 in the blood samples of DN patients as well as in HGMCs, whereas, downregulated levels of miR +other 34742151 hsa-mir-326 Pre-Eclampsia Circ_0032962 could contribute to trophoblast cell growth ability and metastasis partly by regulating the miR-326/PBX3 axis, providing a novel insight into the pathogenesis and treatment of PE. +other 34742033 hsa-mir-140 Urinary Bladder Neoplasms S100A7 was predicted to directly interact with LYZ, which potentially shows competitive binding with hsa-mir-140 to affect the expression of six lncRNAs in MIBC. +lncRNA target 34741930 hsa-mir-326 Pulmonary Fibrosis Our study uncovered a key mechanism by which lnc-SNHG1 regulated pulmonary fibrosis through miR-326/SP1 axis, and lnc-SNHG1 is a potential target for the prevention and treatment of silicosis. +other 34741437 hsa-mir-214 Lung Neoplasms 3p to upregulate TGIF2 expression, thereby promoting the progression of lung cancer cells. +exosome 34741385 hsa-mir-21 Osteosarcoma 5p-abundant exosomes derived human bone marrow MSCs could activate PI3K/Akt/mTOR pathway by suppressing PIK3R1 expression in osteosarcoma cells. +genetics_knock down_suppress 34741382 hsa-mir-32 Mouth Neoplasms 5p, and knockdown of KLF2 abolished the inhibitory effect of miR +lncRNA target 34741343 hsa-mir-146b Neurodevelopmental Injuries INTERPRETATIONS: These findings support that miRNA-146b-5p is a major regulator of microglia phenotype and could be targeted to reduce the incidence and the severity of perinatal brain injuries and their long-term consequences. +other 34741317 hsa-mir-4319 Colorectal Neoplasms Our results reveal the mechanism of the lnc-CPLC/miR-4319/ZBTB34 signal axis in CRC and provide evidence for elucidating the complex molecular mechanisms in tumors. +genetics_GWAS 34741119 hsa-mir-139 Leukemia, Myeloid, Acute We revealed that two enhancer regions control MIR139 expression and found that the polycomb repressive complex 2 (PRC2) downstream of MLL-AF9 epigenetically silenced MIR139 in AML. +other 34740994 hsa-mir-26a Triple Negative Breast Neoplasms In general, our study found (1) miR-26a-5p was a protective factor of breast cancer, while OTUD6B-AS1 and MTDH were risk factors; (2) OTUD6B-AS1 was the up-stream regulator of miR-26a-5p verified by luciferase; (3) up-regulation of miR-26a-5p and down-regulation of MTDH promoted cellular cytotoxicity of paclitaxel (PTX) in vitro and in vivo. +other 34740784 hsa-mir-141 Legg-Calve-Perthes Disease 3p and miR-30a promoted osteoclastogenesis in vitro. +other 34740784 hsa-mir-4644 Legg-Calve-Perthes Disease 3p and miR-30a promoted osteoclastogenesis in vitro. +other 34740784 hsa-mir-3133 Legg-Calve-Perthes Disease 3p and miR-30a promoted osteoclastogenesis in vitro. +other 34740784 hsa-mir-4693 Legg-Calve-Perthes Disease 3p and miR-30a promoted osteoclastogenesis in vitro. +genetics_overexpression_promote 34740363 hsa-mir-182 Polycystic Ovary Syndrome Moreover, miR-182 overexpression suppressed cell proliferation and cell cycle process and promoted cell apoptosis in PCOS GCs and KGN cells by targeting SGK3. +genetics_knock down_promote 34740278 hsa-mir-1229 Carcinoma, Hepatocellular 3p facilitated cell viability and metastasis of HCC cells while knockdown of miR +other 34740040 hsa-mir-9 Uterine Cervical Neoplasms 5p in cervical cancer cells. +lncRNA target 34740018 hsa-mir-145 Tuberculosis, Pulmonary Hence, we concluded that immunoheterogeneity exists among TB patients and NFATC1-(miR145)-STAT1 regulatory pathway might be associated with tuberculosis infection, which may be valuable targets for prevention and treatment of tuberculosis. +lncRNA target 34739601 hsa-mir-171f Dwarfism High-throughput sequencing and yeast one and two-hybrid library screening reveal that DKGA2ox1 and miR171f_3 are involved in the regulation of scion dwarfing with 'Nan-tong-xiao-fang-shi' as interstocks. These results indicate that DKGA2ox1 and miR171f_3 may co-promote the scion dwarfing by plant hormone signal transduction pathways. +other 34739167 hsa-mir-1231 Squamous Cell Carcinoma of Head and Neck Besides, circ_0002141 could sponge miR-1231 and upregulate EGFR expression in OSCC cells. CONCLUSION: Circ_0002141/miR-1231/EGFR axis is involved in the progression of OSCC. +genetics_overexpression_promote 34739163 hsa-mir-590 Periodontitis 3p overexpression improved osteogenic differentiation of hPDLSCs in periodontitis. +transcription factor target 34738916 hsa-mir-652 Growth Hormone-Secreting Pituitary Adenoma Downregulated miR-216a-5p and miR3p expression may contribute to tumour progression by targeting JAK2 and PRRX1 on GH-producing pituitary tumours. +transcription factor target 34738916 hsa-mir-216a Growth Hormone-Secreting Pituitary Adenoma Downregulated miR-216a-5p and miR3p expression may contribute to tumour progression by targeting JAK2 and PRRX1 on GH-producing pituitary tumours. +other 34738893 hsa-mir-146a Coronary Disease PURPOSE OF THE STUDY The aim of the study was to determine miR-146a-5p, miR3p and miR-23a-3p by an enzyme immunoassay in patients with inflammatory and non-inflammatory joint effusion and to verify the usefulness of these miRNAs as biomarkers of joint inflammation. +other 34738893 hsa-mir-23a Coronary Disease PURPOSE OF THE STUDY The aim of the study was to determine miR-146a-5p, miR3p and miR-23a-3p by an enzyme immunoassay in patients with inflammatory and non-inflammatory joint effusion and to verify the usefulness of these miRNAs as biomarkers of joint inflammation. +other 34738893 hsa-mir-223 Coronary Disease PURPOSE OF THE STUDY The aim of the study was to determine miR-146a-5p, miR3p and miR-23a-3p by an enzyme immunoassay in patients with inflammatory and non-inflammatory joint effusion and to verify the usefulness of these miRNAs as biomarkers of joint inflammation. +genetics_overexpression_promote 34738872 hsa-mir-877 Osteosarcoma 3p overexpression was found to inhibit the proliferation of OS cell lines. +lncRNA target 34738869 hsa-mir-513b Breast Neoplasms However, to date, the functional role and underlying regulatory mechanism of LINC00675 and miR-513b-5p in BC remains largely unknown. Collectively, the central findings of our study suggest that LINC00675 represses BC progression through the inhibition of miR-513b-5p in a m(6)A-dependent manner. +other 34738867 hsa-mir-223 Acute Uterine Injury Collectively, we concluded that BMSCs-exo upregulated miR3p to degrade NLRP3 in EPCs, which further reversed the cytotoxic effects of LPS treatment on EPCs to ameliorate LPS-induced AUI. +genetics_knock down_promote 34738865 hsa-mir-124a Adenocarcinoma of Lung Moreover, LINC00960 sponged miR-124a to inhibit the SphK1/S1P pathway in LADC cells. In addition, miR-124a downregulation or SphK1 upregulation reversed the inhibitory effects of LINC00960 knockdown on cellular functions of LADC cells, suggesting that LINC00960 may be a potential therapeutic biomarker for LADC via the miR-124a/SphK1 axis. +lncRNA target 34738862 hsa-mir-1207 Nasopharyngeal Carcinoma 5p expression and affecting TEAD1 expression, thus inhibiting the activation of Hippo/YAP signaling pathway. +genetics_knock down_promote 34738852 hsa-mir-423 Thyroid Cancer, Papillary Circ_0039411 knockdown-mediated effects in papillary thyroid carcinoma cells were largely overturned by the silence of miR +circulation_biomarker_diagnosis_ns 34738631 hsa-mir-145 Fibrosis The expression levels of MEG3 and microRNA (miR)145 in the serum of healthy volunteers and patients with liver fibrosis and in LX2 cells were detected using reverse transcriptionquantitative PCR. +other 34738503 hsa-mir-20a alpha-Thalassemia Our results suggest that circMTO1 modulates ATRX expression to accelerate OSCC progression by sponging miR-320a. Our study showed a novel ZNF460/circMTO1/miR-320a/ATRX signaling in OSCC development. +other 34738503 hsa-mir-20a Mental Retardation, X-Linked Our results suggest that circMTO1 modulates ATRX expression to accelerate OSCC progression by sponging miR-320a. Our study showed a novel ZNF460/circMTO1/miR-320a/ATRX signaling in OSCC development. +other 34738503 hsa-mir-20a Squamous Cell Carcinoma of Head and Neck Our results suggest that circMTO1 modulates ATRX expression to accelerate OSCC progression by sponging miR-320a. Our study showed a novel ZNF460/circMTO1/miR-320a/ATRX signaling in OSCC development. +other 34738502 hsa-mir-149 Breast Neoplasms 5p/SLC1A5 pathway, providing a novel mechanism responsible for BC development. +genetics_knock down_promote 34738458 hsa-mir-361 Pancreatitis Gain- and loss-of-function assays of miR +other 34738402 hsa-mir-199 Cardiomegaly The mRNA expression of myocardial hypertrophy indicators(ANP and BNP), autophagy-related genes(Atg5, P62 and beclin1), and miR199 a-5 p was detected by qRT-PCR. +circulation_biomarker_prognosis_ns 34738345 hsa-mir-150 Sepsis RESULTS: Multivariate analysis demonstrated that miR-150 (odds ratio (OR): 0.549, 95% confidence interval (95% CI) [0.372, 0.826], p < 0.001), the SOFA score (OR: 1.216, 95% CI [1.039, 1.807], p = 0.008), age, procalcitonin (PCT), and septic shock were independently associated with 28-day mortality of sepsis patients following the adjustment for chronic renal failure, hypertension, diabetes mellitus, activated partial thromboplastin time (APTT), serum creatinine (SCr), blood urea nitrogen (BUN), and total bilirubin (TBil). +other 34738200 hsa-mir-153 Laryngeal Neoplasms CONCLUSIONS: Our results indicate that hsa-circ_0058106 induces EMT and metastasis in laryngeal cancer by sponging miR-153 and inducing Twist1 nuclear translocation. +genetics_overexpression_promote 34737955 hsa-mir-449a Colorectal Neoplasms Either activation of autophagy by the inducer or overexpression of exogenous miR-449a decreases the expression of target gene LEF-1 and cyclin D1, which lead to decreased proliferation, colony formation, migration, and invasion of CRC cells. +target gene 34737805 hsa-mir-4486 Colonic Neoplasms miR-4486 reverses cisplatin-resistance of colon cancer cells via targeting ATG7 to inhibiting autophagy. +circulation_biomarker_diagnosis_up 34737798 hsa-mir-185 Diabetes Mellitus The expression of NOS2 was upregulated and the expression of miR-185 was downregulated in the blood from patients with diabetes. +lncRNA target 34737762 hsa-mir-222 Thyroid Neoplasms 3p and its critical target genes could be promising biomarkers for the prognosis of THCA and may emerge as key regulators of immune infiltration in THCA. +genetics_overexpression_promote 34737643 hsa-mir-4500 Precursor Cell Lymphoblastic Leukemia-Lymphoma In this study, we investigated how LINC00265 and miR-4500 regulate the malignant characteristics of ALL. Furthermore, miR-4500 inhibitors or overexpressed LINC00265 up-regulated STAT3 expression, and miR-4500 mimics or STAT3 shRNAs eliminated the LINC00265-induced malignancy of the ALL cells. +transcription factor target 34737423 hsa-mir-28 Osteoarthritis In conclusion, our data reveal that AC008 plays a critical role in OA pathogenesis via the miR +other 34737026 hsa-mir-122 Diabetes Mellitus, Type 2 In the mediation analysis, miR5p mediated 48.0% of the association between Ti and diabetes risk. +circulation_biomarker_diagnosis_ns 34736693 hsa-mir-210 Triple Negative Breast Neoplasms In this work, a novel electrochemiluminescence (ECL) sensor has been developed to detect miRNA-210 in the serum of triple negative breast cancer (TNBC) patients. +lncRNA target 34736391 hsa-mir-200a Kidney Diseases CONCLUSION: LncRNA-ATB promoted the COM-induced cell injury, cell apoptosis, proliferation inhibition, and EMT to participate in the process of CaOx crystal-induced renal injury by sponging miR-200s. +lncRNA target 34736391 hsa-mir-200 Kidney Diseases CONCLUSION: LncRNA-ATB promoted the COM-induced cell injury, cell apoptosis, proliferation inhibition, and EMT to participate in the process of CaOx crystal-induced renal injury by sponging miR-200s. +genetics_overexpression_promote 34736163 hsa-mir-552 Carcinoma, Non-Small-Cell Lung 3p inhibitor, Fibulin 5 (FBLN5) overexpression plasmid, and small interfering FBLN5 (siFBLN5) and treated with extracellular regulated protein kinases (ERK) pathway inhibitor PD98059. +exosome 34735868 hsa-mir-875 Stomach Neoplasms CONCLUSION: GCCs-exosomal lncRNA HCG18 elevated KLF4 expression by decreasing miR +other 34735495 hsa-mir-153 Diabetic Nephropathies Non-coding genes that interact with Hub genes, including hsa-miR-572, hsa-miR-29a-3p, hsa-miR-29b-3p, hsa-miR-208a-3p, hsa-miR3p and hsa-miR-29c-3p, may be related to diabetic nephropathy. +other 34735495 hsa-mir-572 Diabetic Nephropathies Non-coding genes that interact with Hub genes, including hsa-miR-572, hsa-miR-29a-3p, hsa-miR-29b-3p, hsa-miR-208a-3p, hsa-miR3p and hsa-miR-29c-3p, may be related to diabetic nephropathy. +other 34735495 hsa-mir-29c Diabetic Nephropathies Non-coding genes that interact with Hub genes, including hsa-miR-572, hsa-miR-29a-3p, hsa-miR-29b-3p, hsa-miR-208a-3p, hsa-miR3p and hsa-miR-29c-3p, may be related to diabetic nephropathy. +other 34735495 hsa-mir-208a Diabetic Nephropathies Non-coding genes that interact with Hub genes, including hsa-miR-572, hsa-miR-29a-3p, hsa-miR-29b-3p, hsa-miR-208a-3p, hsa-miR3p and hsa-miR-29c-3p, may be related to diabetic nephropathy. +other 34735495 hsa-mir-29b Diabetic Nephropathies Non-coding genes that interact with Hub genes, including hsa-miR-572, hsa-miR-29a-3p, hsa-miR-29b-3p, hsa-miR-208a-3p, hsa-miR3p and hsa-miR-29c-3p, may be related to diabetic nephropathy. +other 34735495 hsa-mir-29a Diabetic Nephropathies Non-coding genes that interact with Hub genes, including hsa-miR-572, hsa-miR-29a-3p, hsa-miR-29b-3p, hsa-miR-208a-3p, hsa-miR3p and hsa-miR-29c-3p, may be related to diabetic nephropathy. +lncRNA target 34735003 hsa-mir-494 Pulmonary Fibrosis Our study indicated that PM2.5 exposure triggered EMT progression to promote the pulmonary fibrosis via miR3p/YTHDF2 recognized and METTL3 mediated m6A modification. +genetics_knock down_suppress 34734406 hsa-mir-519d Lung Neoplasms LINC00839 competitively sponged miR-519d-3p, increasing JMJD6 expression, LC cell viability, invasion, migratory abilities and decreasing apoptosis rates in A549 and H460 lung cancer cells, which were hindered after JMJD6 knockdown. CONCLUSIONS: LINC00839/miR-519d-3p/JMJD6 axis mediated cell viability, apoptosis, and migration and invasiveness of H460 lung cancer cells. +other 34734021 hsa-mir-134 Tourette Syndrome CONCLUSIONS: The rat models of TS and comorbid fear have similar changes in behaviors and miRNA-134 level to those in clinical settings and therefore can be used as a reliable animal model to study the mechanism of action of TS and comorbid fear. +transcription factor target 34734010 hsa-mir-205 Pulmonary Arterial Hypertension 3p may be potential therapeutic targets in patients with SSc-PAH. +transcription factor target 34734010 hsa-mir-205 Scleroderma, Systemic 3p may be potential therapeutic targets in patients with SSc-PAH. +transcription factor target 34734010 hsa-mir-539 Pulmonary Arterial Hypertension 3p may be potential therapeutic targets in patients with SSc-PAH. +transcription factor target 34734010 hsa-mir-539 Scleroderma, Systemic 3p may be potential therapeutic targets in patients with SSc-PAH. +genetics_overexpression_promote 34733975 hsa-mir-29c Squamous Cell Carcinoma of Head and Neck In addition, miR-29c overexpression inhibited the proliferation and metastasis of OSCC cells, and the subsequent rescue experiment showed that SERPINH1 overexpression can reverse the inhibitory effect of miR-29c in OSCC cell proliferation, migration, apoptosis, and cell cycle arrest. +lncRNA target 34733962 hsa-mir-151 Corneal Allograft Rejection 5p alleviated CGR by activating the PI3K/AKT signaling pathway and balancing Th17/Treg via targeting of IL-2Ra, which contributes to improving the results of CT. +transcription factor target 34733957 hsa-mir-155 Inflammation 5p and performing negative regulation analysis, six target genes were obtained in GCs. +transcription factor target 34733957 hsa-mir-155 Polycystic Ovary Syndrome 5p and performing negative regulation analysis, six target genes were obtained in GCs. +transcription factor target 34733957 hsa-mir-106 Polycystic Ovary Syndrome 5p and performing negative regulation analysis, six target genes were obtained in GCs. +transcription factor target 34733957 hsa-mir-106 Inflammation 5p and performing negative regulation analysis, six target genes were obtained in GCs. +lncRNA target 34733939 hsa-mir-223 Hepatitis C CONCLUSIONS: Our findings indicate KCNQ1OT1 promotes HCV-infected beta-cell pyroptosis through the miRNA3p/NLRP3 axis, effecting the production of insulin and accelerating the occurrence and development of T2DM.Regulating KCNQ1OT1 and its target genes will help to better understand the pathogenesis of T2DM induced by HCV infection and provide new theoretical foundations and therapeutic targets. +exosome 34733928 hsa-mir-16 Fever NPCs were pretreated with 10 ng/mL TNF-alpha, transfected with miR-16 inhibitors, and the exosomes were isolated. CONCLUSIONS: The inflammatory factor TNF-alpha stimulated exosome release from NPCs, which induced the apoptosis of normal NPCs through the actions of exosomal miR-16. +genetics_knock down_promote 34733926 hsa-mir-552 Gallbladder Neoplasms 3p was employed to knockdown this miRNA in GBC cell lines. +other 34733921 hsa-mir-214 Colorectal Neoplasms 5p-JAG1 regulatory axis, in exploring the cancer-promoting mechanism of lncRNA FTX in CRC. +other 34733854 hsa-mir-7 Glioblastoma Burst keywords in recent years included glioblastoma, miR-7, skeletal muscle, and non-coding RNA. +genetics_overexpression_promote 34733825 hsa-mir-181a-2 Stomach Neoplasms 3p and MYLK were simultaneously overexpressed. +genetics_overexpression_promote 34733662 hsa-mir-124 Carcinoma, Renal Cell Functionally, the overexpression of miR-124 reduced the sensitivity of renal cancer cells to cisplatin and CAPN4 was found to be a direct target of miR-124, which can negatively regulated CAPN4 expression. +lncRNA target 34733371 hsa-mir-135a Carcinoma, Non-Small-Cell Lung Altogether, the present study suggests that FOXD3-AS1 sponges miR-135a-5p to promote cell proliferation and concomitantly inhibit apoptosis by regulating CDK6 expression in NSCLC cells. +other 34733360 hsa-mir-152 ovary adenocarcinoma In conclusion, MYCNOS may act by sponging miR-152 to upregulate MKK7 expression in OA, thereby promoting cell proliferation. +lncRNA target 34733326 hsa-mir-185 Colorectal Neoplasms UCA1 promotes CRC metastasis through regulating the miR-185/NOTCH3 axis. +target gene 34733314 hsa-mir-320d Colorectal Neoplasms MiR-320d Inhibits Progression of EGFR-Positive Colorectal Cancer by Targeting TUSC3. +genetics_knock down_promote 34732848 hsa-mir-211 Cardiomegaly Furthermore, overexpression of TINCR suppressed TAC-induced cardiac hypertrophy in vivo by targeting miR +genetics_GWAS 34732693 hsa-mir-497 Choriocarcinoma Silencing miR5p and SALL4 promotes choriocarcinoma progression and forms a feedback loop with DNMT-mediated epigenetic regulation, playing a crucial role in stemness maintenance in choriocarcinoma. +circulation_biomarker_diagnosis_ns 34732690 hsa-mir-4449 Diabetic Nephropathies CONCLUSIONS: Our study uncovered a novel mechanism for the progression of DKD that is mediated through miR-4449 in serum exosomes, which highlights an important role for exosomes in the pathogenesis of DKD. +target gene 34732362 hsa-mir-218 Liver Neoplasms Targeted delivery of miR-218 via decorated hyperbranched polyamidoamine for liver cancer regression. +circRNA target 34732216 hsa-mir-198 Breast Neoplasms CONCLUSIONS: Circ-ERBB2 accelerated HER2-positive breast cancer progression through the circ-ERBB2/miR +circRNA target 34732216 hsa-mir-136 Breast Neoplasms CONCLUSIONS: Circ-ERBB2 accelerated HER2-positive breast cancer progression through the circ-ERBB2/miR +other 34732212 hsa-mir-223 Acute Lung Injury Downregulation of miR-223 promotes HMGB2 expression and induces oxidative stress to activate JNK and promote autophagy in an in vitro model of acute lung injury. +other 34732131 hsa-mir-17 Cardiotoxicity 5p which may be involved in the regulation of genes associated with AIC. +other 34732131 hsa-mir-146a Cardiotoxicity 5p which may be involved in the regulation of genes associated with AIC. +other 34732131 hsa-mir-15b Cardiotoxicity 5p which may be involved in the regulation of genes associated with AIC. +other 34732131 hsa-mir-424 Cardiotoxicity 5p which may be involved in the regulation of genes associated with AIC. +circulation_biomarker_diagnosis_down 34731387 hsa-mir-126 Norrie disease 5p, which were downregulated in DN patient's serum and HG-treated human mesangial cells. +circulation_biomarker_diagnosis_down 34731387 hsa-mir-204 Norrie disease 5p, which were downregulated in DN patient's serum and HG-treated human mesangial cells. +circulation_biomarker_diagnosis_up 34731387 hsa-mir-204 Hyperglycemia 5p, which were downregulated in DN patient's serum and HG-treated human mesangial cells. +circulation_biomarker_diagnosis_up 34731387 hsa-mir-126 Hyperglycemia 5p, which were downregulated in DN patient's serum and HG-treated human mesangial cells. +genetics_knock down_promote 34731384 hsa-mir-370 Acute Kidney Injury Circ-BNIP3L knockdown alleviated LPS-induced renal tubular epithelial cell injury by miR3p/MYD88 axis, opening up a completely new avenue for the treatment of sepsis-associated AKI. +genetics_knock down_promote 34731384 hsa-mir-370 Sepsis Circ-BNIP3L knockdown alleviated LPS-induced renal tubular epithelial cell injury by miR3p/MYD88 axis, opening up a completely new avenue for the treatment of sepsis-associated AKI. +circRNA target 34730838 hsa-mir-488 Carcinoma, Non-Small-Cell Lung CONCLUSION: Circ_0000376 downregulation blocked the development of NSCLC by targeting the miR3p/BRD4 network and suppressing the PI3K/PKB pathway, which broadens knowledge into the understanding of the role of circ_0000376 in NSCLC. +circRNA target 34730679 hsa-mir-193a Carcinoma, Hepatocellular Circ_0001806 could up-regulate MMP16 expression through repressing miR-193a-5p, thereby facilitating the malignant biological behaviors of HCC. +circulation_biomarker_prognosis_up 34730612 hsa-mir-128 Ischemic Stroke CONCLUSION: Assessment of serum miR +circulation_biomarker_prognosis_up 34730612 hsa-mir-9 Ischemic Stroke CONCLUSION: Assessment of serum miR +other 34730446 hsa-mir-22 Cleft Palate CONCLUSIONS: Results from the current study suggest a key role for miR-22 in the removal of the MES during palatogenesis and that miR-22 may represent a potential contributor to the etiology of cleft palate. +other 34730432 hsa-mir-211 Cognition Disorders 5p displayed reduced cortical apoptosis levels and near-term cognitive impairment. +lncRNA target 34730253 hsa-mir-1271 Diabetes Mellitus This study evaluated anti-diabetic activity of hydroxybenzoic acid derivatives and determined the involvement of miR-1271. This study assessed the anti-diabetic activity of hydroxybenzoic acid derivatives through down-regulation of microRNA-1271 and its association with the IRS1/PI3K/AKT/FOXO1 pathways. +genetics_overexpression_promote 34730202 hsa-mir-499b Uterine Cervical Neoplasms MiR-499b-5p overexpression prevented the tumorigenesis and development of cervical cancer in xenograft tumor models. +lncRNA target 34730201 hsa-mir-26a Carcinoma, Hepatocellular CONCLUSIONS: LINC00205, a novel YY1-modulated lncRNA, can facilitate the proliferation of HCC cells through YY1/miR-26a-5p/CDK6 pathway, and may serve as a promising diagnostic biomarker and therapeutic target for HCC. +genetics_knock down_suppress 34730199 hsa-mir-451 Thyroid Neoplasms CONCLUSIONS: Our results indicated that the cell migration and invasion were inhibited by knockdown of lncRNA NORAD or overexpression of miR-451, suggesting that the axis of lncRNA NORAD -miR +genetics_knock down_promote 34730059 hsa-mir-495 Acute Kidney Injury 3p/TRAF6 axis via NF-kappaB/p65 signalling pathway, providing a novel mechanism in clinical treatment of AKI patients.HighlightsCirc_0114427 is upregulated in serum specimens from septic AKI patients and LPS-induced HK-2 cells.LPS treatment suppresses cell viability and promotes apoptosis and inflammation in HK-2 cells.Circ_0114427 knockdown ameliorates the effects of LPS on cell viability, apoptosis and inflammation in HK-2 cells.Circ_0114427 regulates LPS-induced HK-2 cell injury by regulating miR +transcription factor target 34730058 hsa-mir-144 Arthritis, Rheumatoid 3p induced by SP1 could promote IL-1beta-induced chondrocyte pyroptosis via inhibiting PTEN expression and suppressing the activation of PINK1/Parkin signalling, which provided a new strategy against RA. +genetics_knock down_promote 34730058 hsa-mir-144 Necrobiotic Disorders 3p knockdown inhibited IL-1beta-induced pyroptosis in N1511 cells, and the expressions of NOD-like receptor family pyrin domain containing 3 (NLRP3), Cleaved caspase-1, Gasdermin D (GSDMD), and Cleaved caspase-3 in IL-1beta-stimulated N1511 cells were increased. +lncRNA target 34729750 hsa-mir-363 Hemangioma Down-regulating HNF1A-AS1 may inhibit proliferation, migration and invasion of IL +genetics_knock down_promote 34729394 hsa-mir-20b Esophageal Squamous Cell Carcinoma Moreover, overexpression of miR-320b promotes the proliferation, migration, invasion, and epithelial-mesenchymal transition progression of ESCC cells. +circulation_biomarker_diagnosis_ns 34729120 hsa-mir-801 Carcinoma, Hepatocellular Background: This study aimed to evaluate the role of plasma microRNA panel (miR-122, miR-192, miR-21, miR-223, miR-26a, miR-27a and miR-801) for prediction and surveillance of early tumor recurrence in hepatocellular carcinoma (HCC) patients who had undergone liver transplantation (LT). +circulation_biomarker_diagnosis_ns 34729120 hsa-mir-223 Carcinoma, Hepatocellular Background: This study aimed to evaluate the role of plasma microRNA panel (miR-122, miR-192, miR-21, miR-223, miR-26a, miR-27a and miR-801) for prediction and surveillance of early tumor recurrence in hepatocellular carcinoma (HCC) patients who had undergone liver transplantation (LT). +circulation_biomarker_diagnosis_ns 34729120 hsa-mir-122 Carcinoma, Hepatocellular Background: This study aimed to evaluate the role of plasma microRNA panel (miR-122, miR-192, miR-21, miR-223, miR-26a, miR-27a and miR-801) for prediction and surveillance of early tumor recurrence in hepatocellular carcinoma (HCC) patients who had undergone liver transplantation (LT). +circulation_biomarker_diagnosis_ns 34729120 hsa-mir-27a Carcinoma, Hepatocellular Background: This study aimed to evaluate the role of plasma microRNA panel (miR-122, miR-192, miR-21, miR-223, miR-26a, miR-27a and miR-801) for prediction and surveillance of early tumor recurrence in hepatocellular carcinoma (HCC) patients who had undergone liver transplantation (LT). +circulation_biomarker_diagnosis_ns 34729120 hsa-mir-26a Carcinoma, Hepatocellular Background: This study aimed to evaluate the role of plasma microRNA panel (miR-122, miR-192, miR-21, miR-223, miR-26a, miR-27a and miR-801) for prediction and surveillance of early tumor recurrence in hepatocellular carcinoma (HCC) patients who had undergone liver transplantation (LT). +circulation_biomarker_diagnosis_ns 34729120 hsa-mir-192 Carcinoma, Hepatocellular Background: This study aimed to evaluate the role of plasma microRNA panel (miR-122, miR-192, miR-21, miR-223, miR-26a, miR-27a and miR-801) for prediction and surveillance of early tumor recurrence in hepatocellular carcinoma (HCC) patients who had undergone liver transplantation (LT). +circulation_biomarker_diagnosis_ns 34729120 hsa-mir-21 Carcinoma, Hepatocellular Background: This study aimed to evaluate the role of plasma microRNA panel (miR-122, miR-192, miR-21, miR-223, miR-26a, miR-27a and miR-801) for prediction and surveillance of early tumor recurrence in hepatocellular carcinoma (HCC) patients who had undergone liver transplantation (LT). +lncRNA target 34729115 hsa-mir-375 Esophageal Squamous Cell Carcinoma These findings suggest that miR-375 acts as a tumor suppressor by blocking the ERBB2/VEGFA pathway with the potential to modulate the occurrence and/ or progression of EC. +target gene 34729113 hsa-mir-182 Carcinoma, Non-Small-Cell Lung MiR-182-5p promotes the Metastasis and Epithelial-mesenchymal Transition in Non-small Cell Lung Cancer by Targeting EPAS1.expression. +lncRNA target 34729101 hsa-mir-491 Glioma Conclusion: LBX2-AS1 is upregulated by SP1 in glioma, which promotes the progression of glioma by targeting the miR5p/LIF axis. +lncRNA target 34728806 hsa-mir-662 Triple Negative Breast Neoplasms Since miR-3662 expression occurs a tumor-specific manner, it is a promising biomarker and therapeutic target for patients who have TNBCs with dysregulation of miR-3662, especially African Americans. +other 34728784 hsa-mir-17 Stomach Neoplasms 5p and HOXA11-AS activation in GC cells. +transcription factor target 34728702 hsa-mir-146a Acne Vulgaris These findings correlated with our in situ hybridization results, that compared with control, miR-146a showed an increased, while GNG7 a decreased expression in sebaceous glands of acne samples. Our findings suggest, that miR-146a could be a potential player in acne pathogenesis by regulating inflammation, inducing proliferation and, through the indirect down-regulation of GNG7, promoting the lipid production of sebocytes. +lncRNA target 34728310 hsa-mir-130a Glioma KB-1460A1.5 was found to function as a competing endogenous RNA (ceRNA) to regulate the expression of TSC1, a key regulatory component of the mTOR pathway, by sponging miR-130a-3p in glioma cells. In conclusion, this study revealed that lncRNA KB-1460A1.5 inhibits glioma tumorigenesis via miR-130a-3p/TSC1/mTOR/YY1 feedback loop. +genetics_overexpression_promote 34728027 hsa-mir-145 Carcinoma, Ovarian Epithelial 5p(t=4.583,P=0.010).The cells with ARK5 overexpression showed increased proliferation rate(t=27.290,P<0.001)and decreased apoptosis rate(t=-8.241,P=0.001).The overexpression of miR +lncRNA target 34727954 hsa-mir-657 Stomach Neoplasms CONCLUSION: KLF15-mediated TFAP2A-AS1 hampers cell proliferation and migration in GC via miR-3657/NISCH axis. +genetics_knock down_promote 34727925 hsa-mir-1229 Glioma Additionally, VASP was demonstrated to be the target gene of miR-1179 and miR-1229, and VASP overexpression abolished the effect of circRFX3 knockdown on glioma cell progression. +genetics_knock down_promote 34727925 hsa-mir-1179 Glioma Additionally, VASP was demonstrated to be the target gene of miR-1179 and miR-1229, and VASP overexpression abolished the effect of circRFX3 knockdown on glioma cell progression. +other 34727826 hsa-mir-187 Eclampsia miR5p and 187-5p were downregulated in MBC and MPT but upregulated in fetal placental tissue (FPT).. +other 34727826 hsa-mir-146 Eclampsia miR5p and 187-5p were downregulated in MBC and MPT but upregulated in fetal placental tissue (FPT).. +lncRNA target 34727409 hsa-mir-15a Colorectal Neoplasms Taken together, these data demonstrate that miR-15a-3p regulates ferroptosis through targeting GPX4 in CRC cells, illustrating the novel role of microRNA in ferroptosis. +other 34727290 hsa-mir-362 Breast Neoplasms 3p, were evaluated for functional activity in breast cancer cell lines and they showed increased proliferative signals and tumorigenic properties. +other 34727290 hsa-mir-454 Breast Neoplasms 3p, were evaluated for functional activity in breast cancer cell lines and they showed increased proliferative signals and tumorigenic properties. +other 34726256 hsa-mir-486 Bicuspid Aortic Valve Disease The data suggested that miR486 may be considered as a noninvasive biomarker of aortic wall degeneration. +lncRNA target 34726120 hsa-mir-485 Glioblastoma Our study revealed that CDDP retarded glioblastoma cell development via the miR +circRNA target 34725884 hsa-mir-6796 Ischemic Stroke CONCLUSIONS: circSKA3 functioned as a ceRNA for hsa-miR5p to aggravate the progression of ischemic stroke via targeting MMP9. +circulation_biomarker_diagnosis_ns 34725544 hsa-mir-139 Duane Retraction Syndrome The present results demonstrated that miR5p expression was notably reduced in the serum samples of patients with DR, as well as in ARPE-19 cells treated with HG in a time-dependent manner. +genetics_knock down_promote 34725544 hsa-mir-139 Inflammation Mechanistically, knockdown of LMO4 reversed the biological role of miR +target gene 34725345 hsa-mir-576 Urinary Bladder Neoplasms FTO promotes tumour proliferation in bladder cancer via the FTO/miR-576/CDK6 axis in an m6A-dependent manner. +circRNA target 34724864 hsa-mir-106b Carcinoma, Non-Small-Cell Lung The circSLC8A1/miR-106b-5p/FOXJ3 axis may thus represent a promising therapeutic target for the management of NSCLC. +exosome 34724826 hsa-let-7b Hepatitis C We validate that HCV-induced GU-enriched miRNAs (e.g., miR-122, let-7b, and miR-206) upregulated BAFF expression through exosome transmission and TLR7 activation. +exosome 34724826 hsa-mir-122 Hepatitis C We validate that HCV-induced GU-enriched miRNAs (e.g., miR-122, let-7b, and miR-206) upregulated BAFF expression through exosome transmission and TLR7 activation. +exosome 34724826 hsa-mir-206 Hepatitis C We validate that HCV-induced GU-enriched miRNAs (e.g., miR-122, let-7b, and miR-206) upregulated BAFF expression through exosome transmission and TLR7 activation. +lncRNA target 34724669 hsa-mir-21 Nephritis, Interstitial This study aims to investigate whether PFD can attenuate TIF through inhibiting miR-21 in UUO rats. +genetics_knock down_promote 34724268 hsa-mir-576 Pneumonia, Mycoplasma CONCLUSION: Circ_0037078 knockdown promotes trophoblast cell proliferation, migration, invasion, and angiogenesis in vitro by miR5p/IL1RAP axis, providing a novel insight into the etiology of PE. +circulation_biomarker_diagnosis_up 34723781 hsa-mir-889 Lung Neoplasms 3p and HIPK1-related plasmids in human LC cell line A549, several studies were employed for detection of cell growth. +lncRNA target 34723778 hsa-mir-495 Otitis Media with Effusion Functional assays revealed that NEAT1 promoted the OME by targeting miR-495. Our study revealed that lncRNA NEAT1 served as a ceRNA to activate p38 MAPK signaling by targeting miR-495 in OME, which may offer a new target for OME treatment. +circulation_biomarker_prognosis_up 34723759 hsa-mir-1180 Colorectal Neoplasms 3p is downregulated in CRC tissues, blood and cells than normal ones. +transcription factor target 34723712 hsa-mir-9 Adenocarcinoma of Lung 5p promotes LUAD cell progression by modulating ID4 and may become a potential target for LUAD. +epigenetics 34723710 hsa-mir-204 Astrocytoma 5p expression is downregulated by DNA methylation. +circulation_biomarker_diagnosis_up 34722835 hsa-mir-127 Pelizaeus-Merzbacher Disease 5p, PDX1 and SPHK1 in the blood mononuclear cells (BMCs) of PMOP patients. +other 34722832 hsa-mir-181b Graft vs Host Disease The expression level of miR-181a in ALL patients with COVID-19 is significantly up-regulated, while it is reduced in these patients with TTV. +other 34722832 hsa-mir-181b COVID-19 The expression level of miR-181a in ALL patients with COVID-19 is significantly up-regulated, while it is reduced in these patients with TTV. +other 34722832 hsa-mir-181a Precursor Cell Lymphoblastic Leukemia-Lymphoma The expression level of miR-181a in ALL patients with COVID-19 is significantly up-regulated, while it is reduced in these patients with TTV. +other 34722832 hsa-mir-181a Graft vs Host Disease The expression level of miR-181a in ALL patients with COVID-19 is significantly up-regulated, while it is reduced in these patients with TTV. +other 34722832 hsa-mir-181b Precursor Cell Lymphoblastic Leukemia-Lymphoma The expression level of miR-181a in ALL patients with COVID-19 is significantly up-regulated, while it is reduced in these patients with TTV. +other 34722832 hsa-mir-181a COVID-19 The expression level of miR-181a in ALL patients with COVID-19 is significantly up-regulated, while it is reduced in these patients with TTV. +circRNA target 34722778 hsa-mir-874 Carcinoma, Hepatocellular Using luciferase binding assays, we proved that circ_0001588 functions as a molecular ceRNA of miR-874 and that CDK4 acts as a downstream target of miR-874 in HCC. In summary, our results indicate that circ_0001588 acts as a ceRNA and promotes HCC progression by targeting the miR-874/CDK4 signaling pathway. +other 34722769 hsa-mir-663b Acute Lung Injury CONCLUSION: Our research indicated that the hsa-miR-663b-related ceRNA network may contribute to the key regulatory mechanism in LPS-induced changes of autophagy and ALI. +lncRNA target 34722766 hsa-mir-27a Familial Primary Pulmonary Hypertension We further identified 7 key genes (BCL2, GCLM, MSMO1, SLC7A11, SRXN1, TSPAN5, and TXNRD1) and 5 of the key genes (BCL2, MSMO1, SLC7A11, TSPAN5, and TXNRD1) as target genes may be regulated by 6 dysregulated miRNAs (miR5p, miR-27a-3p, miR-27b-3p, miR-26b-5p, miR-199a-5p, and miR-23b-3p) in IPAH. +lncRNA target 34722766 hsa-mir-27b Familial Primary Pulmonary Hypertension We further identified 7 key genes (BCL2, GCLM, MSMO1, SLC7A11, SRXN1, TSPAN5, and TXNRD1) and 5 of the key genes (BCL2, MSMO1, SLC7A11, TSPAN5, and TXNRD1) as target genes may be regulated by 6 dysregulated miRNAs (miR5p, miR-27a-3p, miR-27b-3p, miR-26b-5p, miR-199a-5p, and miR-23b-3p) in IPAH. +lncRNA target 34722766 hsa-mir-26b Familial Primary Pulmonary Hypertension We further identified 7 key genes (BCL2, GCLM, MSMO1, SLC7A11, SRXN1, TSPAN5, and TXNRD1) and 5 of the key genes (BCL2, MSMO1, SLC7A11, TSPAN5, and TXNRD1) as target genes may be regulated by 6 dysregulated miRNAs (miR5p, miR-27a-3p, miR-27b-3p, miR-26b-5p, miR-199a-5p, and miR-23b-3p) in IPAH. +other 34722763 hsa-mir-484 Epilepsy, Temporal Lobe The differences in expression levels of the miR-484 and the three hub genes (CTD-3193O13.9, EFNA5, and PRKCB) observed experimentally in TLE patients compared to those of healthy controls were consistent with the WGCNA prediction. In addition, our results indicate that miR-484 may be a promising novel biomarker for TLE. +genetics_overexpression_promote 34722753 hsa-mir-582 Carcinoma, Non-Small-Cell Lung CONCLUSION: circ_0002346 overexpression suppressed the malignant properties of NSCLC cells by binding to miR +exosome 34722652 hsa-mir-21 Fibrosis, Atrial Conclusions: The blockade of exosome release with GW4869 suppressed AF by alleviating atrial fibrosis in a canine model, which was probably related to profibrotic miR5p enriched in exosomes and its downstream TIMP3/TGF-beta1 pathway. +exosome 34722652 hsa-mir-21 Atrial Fibrillation Conclusions: The blockade of exosome release with GW4869 suppressed AF by alleviating atrial fibrosis in a canine model, which was probably related to profibrotic miR5p enriched in exosomes and its downstream TIMP3/TGF-beta1 pathway. +other 34722629 hsa-mir-520e Glioma Further bioinformatic analysis revealed that the SNHG16/hsa-miR-520e/SYDE1 axis might be involved in glioma development. +genetics_knock down_suppress 34722314 hsa-mir-27a Carcinoma, Non-Small-Cell Lung METHODS: Database, qRT-PCR, Western-blot (WB), and immunohistochemistry were utilized to determine SLC7A11 expression and function, as well as gene iron related to necrosis in clinical tissue specimens and cells; a ferroptosis inducer, inhibitors, and SLC7A11 lentivirus were used to confirm SLC7A11's biological activity in cell viability, oxidative stress, lipid peroxidation, and iron ion enrichment in non-small cell lung cancer (NSCLC) in different cells; lentivirus was used to infect lung adenocarcinoma cell lines to acquire miR-27a-3p overexpression and knockdown cell lines, and to detect SLC7A11 level through qRT-PCR and WB. +transcription factor target 34722307 hsa-mir-629 Prostatic Neoplasms 5p plays an oncogenic role in PCa by targeting AKAP13, which provides a new idea for clinical diagnosis and treatment of complex refractory PCa. +lncRNA target 34722282 hsa-mir-512 Stomach Neoplasms 5p, which targeted on TRIM28 and promoted cancer malignant behaviors of EBVaGC cells. +lncRNA target 34722233 hsa-mir-222 Carcinoma, Transitional Cell 3p/miR-146a-5p and subsequently influenced the expressions of the downstream target genes P27/P21, which, in turn, inhibited the progression of urothelial carcinoma and increased the sensitivity of cancer cells to cisplatin chemotherapy. +lncRNA target 34722233 hsa-mir-146a Carcinoma, Transitional Cell 3p/miR-146a-5p and subsequently influenced the expressions of the downstream target genes P27/P21, which, in turn, inhibited the progression of urothelial carcinoma and increased the sensitivity of cancer cells to cisplatin chemotherapy. +circulation_biomarker_diagnosis_up 34721735 hsa-mir-135 Depression Conclusion The combination of cellular oxidative stress and hormonal levels strongly supports a role for circulating miRNAs; miR-124, miR-34a-5p, miR-135, and miR +circulation_biomarker_diagnosis_up 34721735 hsa-mir-34a Depression Conclusion The combination of cellular oxidative stress and hormonal levels strongly supports a role for circulating miRNAs; miR-124, miR-34a-5p, miR-135, and miR +circulation_biomarker_diagnosis_up 34721735 hsa-mir-451 Depression Conclusion The combination of cellular oxidative stress and hormonal levels strongly supports a role for circulating miRNAs; miR-124, miR-34a-5p, miR-135, and miR +circulation_biomarker_diagnosis_up 34721735 hsa-mir-124 Depression Conclusion The combination of cellular oxidative stress and hormonal levels strongly supports a role for circulating miRNAs; miR-124, miR-34a-5p, miR-135, and miR +other 34721678 hsa-mir-98 Lupus Nephritis MicroRNA (miR)5p has been reported to be involved in the development of lupus nephritis (LN); however, its specific role in LN remains unclear. +lncRNA target 34721678 hsa-mir-98 Lesch-Nyhan Syndrome 5p and BACH1 may represent potential therapeutic targets for LN. +genetics_overexpression_promote 34721589 hsa-mir-20a Lupus Nephritis The aim of our study was to investigate the efficacy of miR-20a overexpressing adipose-derived stem cell (ADSC) transplantation in murine lupus nephritis (LN) and explore potential molecular mechanisms. CONCLUSIONS: miR-20a-ADSC transplantation prevents the development of lupus nephritis and significantly ameliorates already-established disease, and its mechanism is related to autophagy by targeting the miR-20a-regulated mTOR pathway. +lncRNA target 34721576 hsa-mir-934 Carcinoma, Hepatocellular In this study, our purpose is to explore the biological function of B3GALT5-AS1 in HCC and its coupling mechanism with miR-934 and ubiquitin-fold modifier 1 (UFM1). Our results demonstrated that B3GALT5-AS1 was an excellent HCC suppressant by regulating miR-934 and UFM1 to achieve negative regulation of HCC cell proliferation, invasion, and metastasis, indicating that B3GALT5-AS1 is a promising potential therapeutic target for HCC treatment. +lncRNA target 34721542 hsa-mir-147b Osteoarthritis More importantly, highly specific co-expression RNA (ceRNA) networks regulated by lncRNA LOC107986251-miR5p-SESN3 and hsa_circ_0018069-miR-147b-3p-TJP2 were screened out during IL-induced meniscus degeneration, unveiling potential therapeutic targets for meniscus degeneration during the OA process. +lncRNA target 34721542 hsa-mir-212 Osteoarthritis More importantly, highly specific co-expression RNA (ceRNA) networks regulated by lncRNA LOC107986251-miR5p-SESN3 and hsa_circ_0018069-miR-147b-3p-TJP2 were screened out during IL-induced meniscus degeneration, unveiling potential therapeutic targets for meniscus degeneration during the OA process. +circRNA target 34721518 hsa-mir-452 Glioma Taken together, our findings show that circTLK1 mediated by PBX2 activates JAK/STAT signaling to promote glioma progression through the miR5p/SSR1 pathway. +transcription factor target 34721432 hsa-mir-4512 Lupus Erythematosus, Systemic TLR4-CXCL2 axis as a potential novel therapeutic target in SLE. +genetics_overexpression_suppress 34721048 hsa-mir-320d Chordoma NONHSAT114552 was overexpressed while miR-320d was down-regulated in chordoma tissue compared to fetal nucleus pulposus. +genetics_knock down_promote 34720057 hsa-mir-20a Retinoblastoma Downregulation of miR-320a obviously attenuated the inhibitory effects of knockdown of FTX in RB malignant phenotypes, and knockdown of WNK1 also reversed the impacts of miR-320a inhibitor on malignant phenotypes. Our results revealed that FTX promoted RB progression by targeting the miR-320a/WNK1 axis (graphical abstract), suggesting that FTX might be a novel therapeutic target for RB. +genetics_overexpression_promote 34720052 hsa-mir-149 Carcinoma, Hepatocellular Besides, the rescue experiments were performed by co-transfection with cric_0011385 overexpression plasmid, si-cric_0011385, miR +lncRNA target 34720049 hsa-mir-214 Urinary Bladder Neoplasms In conclusion, YY1-induced PSMA3-AS1 exerted an oncogenic function in BC cells via targeting miR +lncRNA target 34719830 hsa-mir-381 Thyroid Carcinoma, Anaplastic 3p and HOXA9 may be promising molecular targets for preventing ATC progression and drug resistance. +circulation_biomarker_diagnosis_up 34719421 hsa-mir-138 cough variant asthma OBJECTIVES: To study the expression levels of microRNA-138 (miR-138) and Runt-related transcription factor 3 (RUNX3) in peripheral blood of children with cough variant asthma (CVA) and their regulatory effects on Th1/Th2 balance. +genetics_knock down_promote 34719417 hsa-mir-506 Precursor Cell Lymphoblastic Leukemia-Lymphoma The multivariate COX regression analysis showed that leukocyte count 50109/L, medium-high risk stratification, MLL gene rearrangement, miR-9221.46, and miR-5062.17 could indicate poor prognosis in children with ALL (P<0.05). +genetics_knock down_promote 34719417 hsa-mir-922 Precursor Cell Lymphoblastic Leukemia-Lymphoma The multivariate COX regression analysis showed that leukocyte count 50109/L, medium-high risk stratification, MLL gene rearrangement, miR-9221.46, and miR-5062.17 could indicate poor prognosis in children with ALL (P<0.05). +genetics_overexpression_promote 34719318 hsa-mir-7 Glioma miR-7 overexpression inhibited cell viability, invasion, and colony formation ability via reducing CDK4 in glioma cells. +circulation_biomarker_diagnosis_up 34719090 hsa-mir-193b Angelman Syndrome The expressions of miR-193b-3p in the serum of AS patients were detected. +other 34718921 hsa-mir-506 Insulin Resistance 3p altered IR in adipocytes by regulating S6K1-mediated PI3K/AKT pathway activation. +genetics_overexpression_promote 34718359 hsa-mir-181a Multiple Myeloma CONCLUSIONS: CD138+ overexpression of miR-181a was strongly correlated with inferior disease outcome and contributed to superior prediction of MM patients early progression, supporting personalised prognosis and treatment decisions. +other 34718338 hsa-mir-106a Bone Neoplasms These findings demonstrated that restoring the expression of TP53INP1 by silencing miR-106a may be a novel therapeutic strategy for bone metastatic in lung adenocarcinoma. +other 34718338 hsa-mir-106a Lung Neoplasms These findings demonstrated that restoring the expression of TP53INP1 by silencing miR-106a may be a novel therapeutic strategy for bone metastatic in lung adenocarcinoma. +exosome 34718264 hsa-mir-149 Bipolar Disorder Because miR-149 has been shown to inhibit glial proliferation, we hypothesized that increased miR-149 expression in BA24-derived exosomes may be consistent with the previously reported reduced glial cell numbers in BA24 of patients diagnosed with familial BD. +other 34718247 hsa-mir-128 Hypoxia-Ischemia, Brain 3p/Bax/Akt/GSK-3beta axis. +lncRNA target 34718169 hsa-mir-194 Carcinoma, Hepatocellular 5p inhibitor reversed the suppressive effects of sh-LINC01006 on the proliferation, invasion, and migration abilities of HCC cells. +circulation_biomarker_diagnosis_up 34717969 hsa-mir-203 Diabetic Foot Results showed that before NPWT, levels of hsa-miR-203 in peripheral plasma (P-miR-203) and wound margin tissue (T-miR-203) of DFU group were obviously increased compared to SUC group while expression of P-miR-203 decreased in NDFU group compared with NC group. +lncRNA target 34717922 hsa-mir-338 Neuralgia While additional work is needed to confirm these findings, validated target analysis suggests a neuroprotective role of miR +lncRNA target 34717922 hsa-mir-338 Spinal Cord Injuries While additional work is needed to confirm these findings, validated target analysis suggests a neuroprotective role of miR +other 34717910 hsa-mir-21 Pulmonary Arterial Hypertension Cold exposure promoted a greater decrease in miR5p, Bmpr2, Smad5, Tgfbr2, and Smad3 mRNA expression in lungs of the MCT Cold group. +lncRNA target 34717732 hsa-mir-200b Breast Neoplasms RESULTS: Here we designate SE-lncRNAs RP11-379F4.4 and RP11-465B22.8 as potential markers of progression of DCIS to IDC through regulation of the expression of their neighboring genes (RARRES1 and miR-200b, respectively). +transcription factor target 34717687 hsa-mir-17 Retinoblastoma Using TargetScan and the 3'-untranslated region luciferase reporter assays, we show that the direct target of miR-17 is the retinoblastoma gene (RB1), a gene that is pivotal to osteoblastic differentiation. +genetics_knock down_promote 34717683 hsa-mir-646 Osteosarcoma CONCLUSION: Circ_0000006 knockdown promoted DOX-mediated effects on OS development by miR-646/BDNF pathway, which provided a theoretical basis in treating OS with DOX. +genetics_knock down_suppress 34717611 hsa-mir-138 Cystic Fibrosis BACKGROUND: We previously reported that expression of a miR-138 mimic or knockdown of SIN3A in primary cultures of cystic fibrosis (CF) airway epithelia increased DeltaF508-CFTR mRNA and protein levels, and partially restored CFTR-dependent chloride transport. +lncRNA target 34717195 hsa-mir-192 Asthma PTTG3P promoted progression of childhood asthma by targeting the miR +transcription factor target 34717064 hsa-mir-18a Asthma MiR-18a inhibits PDGF-BB-induced proliferation, migration and phenotypic conversion of ASMCs by inhibiting the PI3K/AKT pathway, thus attenuating airway remodeling in asthma. +circulation_biomarker_diagnosis_up 34716993 hsa-mir-146a Rhinitis, Allergic METHODS: Expression of miR-146a and STAT5b in peripheral blood mononuclear cells (PBMCs) and nasal mucosa from patients with AR was detected by qPCR and Western blotting. +lncRNA target 34716872 hsa-mir-224 Glioma 5p targeted CHSY1 and LINC01094 up-regulated CHSY1 by targeting miR +genetics_knock down_suppress 34716858 hsa-mir-874 Carcinoma, Ovarian Epithelial 3p was found in SKOV3-DDP cells; it was also in association with cisplatin-resistance in EOC cells. +circulation_biomarker_diagnosis_ns 34716815 hsa-mir-21 Heart Failure It was successfully used to detect miRNA-21 directly in serum samples from heart failure patients without previous RNA extraction neither amplification process. +other 34716815 hsa-mir-21 Cardiovascular Diseases A simple carbon nanodot-based electrogenerated chemiluminescence biosensor is described for sensitive and selective detection of microRNA-21 (miRNA-21), a biomarker of several pathologies including cardiovascular diseases (CVDs). +circulation_biomarker_diagnosis_ns 34716495 hsa-mir-21 Lung Neoplasms Most importantly, this approach was successfully applied to the detection of plasma exosomal microRNA-21 in patients with lung cancer, and it is proposed that other targets can also be detected by changing the FAM-H1 and FAM-H2 corresponding to the target sequence. +other 34716428 hsa-mir-215 Obesity Quantitative polymerase chain reaction (qPCR) demonstrated that expression of miR-31 and miR-215 was significantly (p < 0.05) higher, 143-fold and 15-fold respectively, in obese than in non-obese individuals. +other 34716428 hsa-mir-1 Obesity Quantitative polymerase chain reaction (qPCR) demonstrated that expression of miR-31 and miR-215 was significantly (p < 0.05) higher, 143-fold and 15-fold respectively, in obese than in non-obese individuals. +circRNA target 34716323 hsa-mir-612 Carcinoma, Hepatocellular In conclusion, CircETFA can increase the expression of CCL5 to promote the progression of HCC by sponging hsa-mir-612 and recruiting EIF4A3, and is promising as a novel biomarker and therapeutic target. +lncRNA target 34716310 hsa-mir-361 Osteosarcoma 3p/FZD4 axis plays an important role in OS progression and might be a potential therapeutic target. +other 34716304 hsa-mir-3175 Necrosis Importantly, miR-3175 expression was decreased in necrotic femoral head tissues of dexamethasone-taking patients, where DCAF1 mRNA was upregulated. +genetics_overexpression_suppress 34716285 hsa-mir-1205 Osteosarcoma Interestingly, overexpressed PTBP1 (or miR-1205 inhibition) reversed the inhibitory effects mediated by circFAM120B downregulation in OS cells. +other 34716242 hsa-mir-192 Glomerulonephritis, Membranous RESULTS: Glomerular endothelial cell (GEC)-derived miR5p and podocyte-derived miR-378a-3p are upregulated in urine and glomeruli of patients with iMGN, whereas glomerular NPNT is reduced. +other 34716242 hsa-mir-378a Glomerulonephritis, Membranous RESULTS: Glomerular endothelial cell (GEC)-derived miR5p and podocyte-derived miR-378a-3p are upregulated in urine and glomeruli of patients with iMGN, whereas glomerular NPNT is reduced. +circulation_biomarker_diagnosis_up 34715911 hsa-mir-638 Diabetic Nephropathies CONCLUSIONS: Serum miR-638 expression was low in DN and can be a potentially valuable biomarker for DN. +genetics_knock down_promote 34715859 hsa-mir-509 Carcinoma, Non-Small-Cell Lung Knockdown of ASAP1-IT1 or overexpression of miR +genetics_knock down_promote 34715856 hsa-mir-124 Stomach Neoplasms Through overexpression/knockdown experiments and function tests in vitro, we demonstrated HOXA11-AS can promote ITGB3 expression by sponging miR +lncRNA target 34715819 hsa-mir-545 Stomach Neoplasms CONCLUSION: LINC00342 plays a potential oncogenic role in GC by targeting the miR545-5p/CNPY2 axis, and might act as a novel therapeutic target for GC. +genetics_overexpression_promote 34715618 hsa-mir-192 Arthritis, Gouty 5p overexpression induced by miR +transcription factor target 34715574 hsa-mir-124 Rhinitis, Allergic 3p /DPP4 axis may be an attractive target for AR therapy. +exosome 34715573 hsa-mir-98 Myocardial Reperfusion Injury CONCLUSION: Hypoxia-induced BMSC-exos elevated miR +genetics_overexpression_promote 34715498 hsa-mir-361 Arthritis, Rheumatoid By qRT-PCR, GAS5 and PDK4 were found to be overexpressed in synovial tissue, fibroblast-like synoviocytes of RA patients and LPS-induced chondrocytes, while the miR +genetics_overexpression_promote 34715270 hsa-mir-214 Alzheimer Disease 5p and down-regulated SUZ12, and the overexpression of miR +genetics_overexpression_promote 34715270 hsa-mir-214 Nerve Degeneration 5p and down-regulated SUZ12, and the overexpression of miR +other 34714963 hsa-mir-125a Glioma CONCLUSIONS: LncRNA MIR4435-2HG obstructs the functions of miR-125a-5p and promotes neuroglioma development by upregulating the TAZ gene. +genetics_overexpression_promote 34714955 hsa-mir-423 Adenocarcinoma of Lung 3p overexpression could rescue the impairment of LUAD cell proliferation, invasion, adhesion, and EMT caused by CYBRD1 depletion. +genetics_GWAS 34714557 hsa-mir-9 Vitiligo To conduct a clinical biochemical study that aids in investigation of some non-coding RNA expressions and polymorphisms (including long non-coding RNAs and miRNAs) namely, MALAT-1 and miR-9 in attempt to provide new diagnostic biomarkers in vitiligo patients for Egyptians. miR-9 as well as long non-coding MALAT-1 may be considered as biomarkers for vitiligo susceptibility which may provide a new direction for treatment. +genetics_knock down_promote 34713767 hsa-mir-7 Stomach Neoplasms 5p could restore cell function, EGFR expression of GC cells when linc00467 knockdown occurs. +genetics_GWAS 34713722 hsa-mir-223 Coronary Artery Disease Conclusions GAS5 rs55829688 polymorphism might affect clopidogrel response in patients with CAD with the CYP2C19 poor metabolizer genotypes, and GAS5 regulates P2Y12 expression and clopidogrel response by acting as a competitive endogenous RNA for miR +lncRNA target 34713362 hsa-mir-7a Diabetes Mellitus Our results indicate that therapeutic inhibition of miR-7a function could be of relevance for preserving the function of pancreatic beta-cells during the course of diabetes development, implicating miR-7, ISL1, and/or the connecting molecules may act as novel targets for pharmacological or gene therapy in diabetes and related metabolic disease, although much detailed studies are required in the further study. +lncRNA target 34713362 hsa-mir-7 Diabetes Mellitus Our results indicate that therapeutic inhibition of miR-7a function could be of relevance for preserving the function of pancreatic beta-cells during the course of diabetes development, implicating miR-7, ISL1, and/or the connecting molecules may act as novel targets for pharmacological or gene therapy in diabetes and related metabolic disease, although much detailed studies are required in the further study. +lncRNA target 34713362 hsa-mir-7a Metabolic Diseases Our results indicate that therapeutic inhibition of miR-7a function could be of relevance for preserving the function of pancreatic beta-cells during the course of diabetes development, implicating miR-7, ISL1, and/or the connecting molecules may act as novel targets for pharmacological or gene therapy in diabetes and related metabolic disease, although much detailed studies are required in the further study. +lncRNA target 34713362 hsa-mir-7 Metabolic Diseases Our results indicate that therapeutic inhibition of miR-7a function could be of relevance for preserving the function of pancreatic beta-cells during the course of diabetes development, implicating miR-7, ISL1, and/or the connecting molecules may act as novel targets for pharmacological or gene therapy in diabetes and related metabolic disease, although much detailed studies are required in the further study. +transcription factor target 34713306 hsa-mir-483 Dermatitis, Atopic The high dose MSC treatment is efficacious in alleviating the clinical signs of cAD until 30 days after the last subcutaneous administration of MSCs, and miRNA-483 may be a reliable prognostic biomarker for cAD. +lncRNA target 34713296 hsa-mir-133a Breast Neoplasms miR16, miR133a and miR223 were transfected into a human breast cancer cell line, MDAMB231. Our results indicated that miR16 promoted osteoclast activities and bone destruction caused by breast cancer metastasis in the bone microenvironment, whereas miR133a and miR223 suppressed them. +lncRNA target 34713296 hsa-mir-223 Breast Neoplasms miR16, miR133a and miR223 were transfected into a human breast cancer cell line, MDAMB231. Our results indicated that miR16 promoted osteoclast activities and bone destruction caused by breast cancer metastasis in the bone microenvironment, whereas miR133a and miR223 suppressed them. +lncRNA target 34713296 hsa-mir-16 Breast Neoplasms miR16, miR133a and miR223 were transfected into a human breast cancer cell line, MDAMB231. Our results indicated that miR16 promoted osteoclast activities and bone destruction caused by breast cancer metastasis in the bone microenvironment, whereas miR133a and miR223 suppressed them. +genetics_knock down_promote 34713294 hsa-mir-203 Hemangioma Knockdown of lncRNA MEG8 inhibits cell proliferation and invasion, but promotes cell apoptosis in hemangioma, via miR203induced mediation of the Notch signaling pathway. In conclusion, the findings of the present study suggested that lncRNA MEG8 knockdown may inhibit cell proliferation and invasion, but promote cell apoptosis in hemangioma via miR203induced mediation of the Notch signaling pathway. +circulation_biomarker_diagnosis_ns 34712934 hsa-mir-181b Fibrosis Conclusions Serum miR-181b-5p is a promising non-invasive biomarker to identify patients with compensated cirrhosis at risk of ascites development. +circulation_biomarker_diagnosis_ns 34712934 hsa-mir-181b Ascites Conclusions Serum miR-181b-5p is a promising non-invasive biomarker to identify patients with compensated cirrhosis at risk of ascites development. +other 34712662 hsa-mir-493 Atherosclerosis 5p for peripheral arterial disease. +other 34712662 hsa-mir-3168 Atherosclerosis 5p for peripheral arterial disease. +other 34712662 hsa-mir-370 Atherosclerosis 5p for peripheral arterial disease. +other 34712662 hsa-mir-2110 Atherosclerosis 5p for peripheral arterial disease. +other 34712662 hsa-mir-409 Atherosclerosis 5p for peripheral arterial disease. +other 34712662 hsa-mir-122 Atherosclerosis 5p for peripheral arterial disease. +other 34712662 hsa-mir-654 Atherosclerosis 5p for peripheral arterial disease. +other 34712662 hsa-mir-215 Atherosclerosis 5p for peripheral arterial disease. +other 34712662 hsa-mir-335 Atherosclerosis 5p for peripheral arterial disease. +other 34712662 hsa-mir-483 Atherosclerosis 5p for peripheral arterial disease. +other 34712662 hsa-mir-381 Atherosclerosis 5p for peripheral arterial disease. +other 34712662 hsa-mir-199a Atherosclerosis 5p for peripheral arterial disease. +lncRNA target 34712659 hsa-mir-30 Reperfusion Injury, Cerebral Ischemia Furthermore, the results showed that miR5p targeted TLR4, which was also upregulated in the infarcted area of MCAO/IR rats and OGD/R PC12 cells. +lncRNA target 34712602 hsa-mir-146a Squamous Cell Carcinoma of Head and Neck Collectively, our study demonstrates that miR-146a regulates CSCs in OSCC through CD24-AKT-beta-catenin axis. +lncRNA target 34712553 hsa-mir-193a Chordoma Therefore, it was concluded that lncRNA KRT8P41, miR-193a-3p, and FUBP1 form a lncRNA-miRNA-mRNA axis, modulating the proliferation and invasion of chordoma cells. +other 34712495 hsa-mir-195 cone-rod dystrophy 6 Results from the experiments manifested upregulated levels of SNHG1 and VEGF-A in HUVECs and CRNV tissues as compared with the control group, whereas downregulated levels of miR5p were measured in the CRNV tissues and HUVECs, suggesting the negative correlation between lncRNA and miRNA. +lncRNA target 34712388 hsa-mir-152 Myocardial Infarction circRNA1615 inhibited ferroptosis in cardiomyocytes, and circRNA1615 could regulate the expression of LRP6 through sponge adsorption of miR +lncRNA target 34712356 hsa-mir-424 Glioma 5p/FAM87A on glioma cells were identified via the cell function experiments. +other 34712340 hsa-mir-338 Nasopharyngeal Carcinoma 3p and the high expression of STAT3 in NPC, which are all related to the TNM stage, T stage, and prognosis of the patient. +exosome 34712334 hsa-mir-141 Osteoporosis KCNQ1OT1-Exos have a more significant inhibitory effect compared to ADSCs-Exos by the function of sponging miR5p, suggesting that KCNQ1OT1-Exos can be promising agents in osteoporosis treatment. +target gene 34712324 hsa-mir-149 Stomach Neoplasms SLCO4A1-AS1 Facilitates the Malignant Phenotype via miR-149-5p/STAT3 Axis in Gastric Cancer Cells. +target gene 34712060 hsa-mir-382 Liver Neoplasms miRNA-382-5p Suppresses the Expression of Farnesoid X Receptor to Promote Progression of Liver Cancer. +other 34711961 hsa-mir-181 Amyotrophic Lateral Sclerosis miRbased ALS biomarkers encourage additional validation and might enhance the power of clinical trials. +transcription factor target 34711123 hsa-mir-375 Retinoblastoma CONCLUSIONS: MiR-375 inhibited RB progression through targeting ERBB2 and suppressing MAPK1/MAPK3 signalling pathway, which might be a new target for the clinical treatment strategy. +genetics_overexpression_suppress 34711122 hsa-mir-133b Adenocarcinoma of Lung Moreover, it was proved by the rescue assay that the overexpression of miR-133b significantly downregulated SKA3 in LUAD cells. +other 34711117 hsa-mir-590 Breast Neoplasms These data suggest that the CASC9/miR3p/SIX1/NF-kappaB axis is involved in breast cancer progression, providing insight into the function of CASC9 in breast cancer development. +lncRNA target 34710881 hsa-mir-223 Acute Kidney Injury 3p via binding to the miR +lncRNA target 34710881 hsa-mir-223 Spinal Cord Injuries 3p via binding to the miR +transcription factor target 34710568 hsa-mir-222 Tuberculosis These results uncover an ESAT6 dependent role for miR3p and its target PTEN in regulating host immune responses to bacterial infection and may provide a potential site for the development of anti-tuberculosis drugs that specifically antagonize the virulence of ESAT6. +transcription factor target 34710568 hsa-mir-222 Drug Hypersensitivity These results uncover an ESAT6 dependent role for miR3p and its target PTEN in regulating host immune responses to bacterial infection and may provide a potential site for the development of anti-tuberculosis drugs that specifically antagonize the virulence of ESAT6. +circulation_biomarker_diagnosis_ns 34710223 hsa-mir-191 Moebius syndrome 1 Thus, this study measured the expression of miRNA-93 and -191 in the serum of adults with MBT and examined the correlations of Injury Severity Score (ISS) and Revised Trauma Score values with serum miRNA-93 and -191 levels in these patients with the aim of predicting trauma severity based on the miRNA levels. +circulation_biomarker_diagnosis_up 34710223 hsa-mir-191 Multiple Trauma In the patients with multitrauma, ISS was significantly, negative and weak correlated with serum miRNA-191 level (rho=-0.320, p=0.023) but not with the serum miRNA-93 level. +circulation_biomarker_diagnosis_ns 34710223 hsa-mir-93 Moebius syndrome 1 Thus, this study measured the expression of miRNA-93 and -191 in the serum of adults with MBT and examined the correlations of Injury Severity Score (ISS) and Revised Trauma Score values with serum miRNA-93 and -191 levels in these patients with the aim of predicting trauma severity based on the miRNA levels. +circulation_biomarker_diagnosis_ns 34710223 hsa-mir-93 Multiple Trauma In the patients with multitrauma, ISS was significantly, negative and weak correlated with serum miRNA-191 level (rho=-0.320, p=0.023) but not with the serum miRNA-93 level. The level of miRNA-191 in conjunction with ISS, but not that of miRNA-93, may be a useful biomarker for determining injury severity in patients with multitrauma. +circulation_biomarker_diagnosis_up 34710223 hsa-mir-191 Wounds and Injuries However, an optimal cutoff value for serum miRNA-191 was identified, with values <1.94 indicating severe trauma (AUC 0.668 [0.511-0.826]; 65.6% sensitivity, 77.8% specificity). +circulation_biomarker_diagnosis_ns 34710223 hsa-mir-93 Wounds and Injuries No optimal cutoff for the serum miRNA-93 level was found with respect to trauma severity (AUC 0.617, [0.455-0.779]). +lncRNA target 34709983 hsa-mir-497 Glioma 5p expression, showing its potential as a prognostic biomarker and a therapeutic target for glioma. +exosome 34709978 hsa-mir-125a Osteoarthritis All these outcomes revealed that BMSCs-derived exosomal miR-125a-5p is a positive regulator for chondrocyte migration and inhibit cartilage degeneration We thus were reasonable to believe that transferring of exosomal miR-125a-5p is a prospective strategy for OA treatment. +genetics_overexpression_promote 34709968 hsa-mir-194 Carcinoma, Non-Small-Cell Lung Pulmonary function tests (PETs) revealed that knocking down circSOX13 or overexpressing miR +genetics_overexpression_promote 34709954 hsa-mir-10b Rhinitis, Allergic CONCLUSION: The present study demonstrates that MIAT overexpression Promotes allergic inflammation and symptoms by activating Th17 immune response via miR-10b-5p inhibition. +genetics_overexpression_promote 34709954 hsa-mir-10b Allergic Inflammation CONCLUSION: The present study demonstrates that MIAT overexpression Promotes allergic inflammation and symptoms by activating Th17 immune response via miR-10b-5p inhibition. +genetics_overexpression_promote 34709725 hsa-mir-491 Leukemia, Myeloid, Acute 5p overexpression-mediated influences in AML cells were effectually overturned by the addition of B4GALT5 overexpression plasmid. +other 34709686 hsa-mir-378 Spinal Cord Injuries 3p in model rats with contusion SCI improved neurological and motor functions. +lncRNA target 34709546 hsa-mir-567 Ovarian Neoplasms circ_0000554 promoted ovarian tumor cell growth, invasion, and EMT via sponging miR-567. +lncRNA target 34709490 hsa-mir-499 Subarachnoid Hemorrhage Our study demonstrates that silencing of MALAT1 alleviates neurocyte apoptosis and reduces ROS production through the miR5p/SOX6 axis after SAH injury. +lncRNA target 34708894 hsa-mir-125a Arthritis, Rheumatoid CONCLUSION: lnc-NEAT1 and its targets (miR-21 and miR-125a) correlate with RA risk and disease activity, and declined lnc-NEAT1 associates with better treatment outcome to some extent in RA patients, suggesting that lnc-NEAT1 might be a potential biomarker to monitor disease activity and treatment outcome in RA. +lncRNA target 34708894 hsa-mir-21 Arthritis, Rheumatoid CONCLUSION: lnc-NEAT1 and its targets (miR-21 and miR-125a) correlate with RA risk and disease activity, and declined lnc-NEAT1 associates with better treatment outcome to some extent in RA patients, suggesting that lnc-NEAT1 might be a potential biomarker to monitor disease activity and treatment outcome in RA. +genetics_overexpression_promote 34708891 hsa-mir-125a Stomach Neoplasms Finally, miR-125a-5p was overexpressed in late-stage GCs, and positive correlations were observed with its targets EphA2, TAZ, and TEAD2. +circulation_biomarker_prognosis_ns 34708885 hsa-mir-210 Ischemic Stroke CONCLUSIONS Serum miR-210 is a weak diagnostic marker of IS. +lncRNA target 34708859 hsa-mir-222 Thyroid Cancer, Papillary 3p can promote the proliferation, migration and invasion of PTC cells through targeting SLC4A4. +transcription factor target 34708638 hsa-mir-346 Thyroiditis, Autoimmune 5p, then act on their target genes to immune and inflammation-related pathways, which may be one of the mechanisms of HPM on EAT rats. +transcription factor target 34708638 hsa-mir-31 Thyroiditis, Autoimmune 5p, then act on their target genes to immune and inflammation-related pathways, which may be one of the mechanisms of HPM on EAT rats. +genetics_knock down_promote 34708547 hsa-mir-374b Melanoma Functionally, UHMK1 overexpression or miR-374b-5p knockdown reversed the suppressive effect of BLACAT1 depletion on melanoma cell proliferation and invasion. +lncRNA target 34708454 hsa-mir-130a Craniocerebral Trauma BACKGROUND MicroRNA-130a (miR-130a) regulates angio-cellular dysregulation, atherosclerosis, and cardiocerebral injuries, serving as a biomarker for major adverse cardiovascular and cerebral events (MACCE) in several chronic diseases. +lncRNA target 34708454 hsa-mir-130a Chronic Disease BACKGROUND MicroRNA-130a (miR-130a) regulates angio-cellular dysregulation, atherosclerosis, and cardiocerebral injuries, serving as a biomarker for major adverse cardiovascular and cerebral events (MACCE) in several chronic diseases. +lncRNA target 34708454 hsa-mir-130a Mycobacterium avium-intracellulare Infection Furthermore, high miR-130a expression at M0, M12, and M36 was significantly correlated with prolonged MACCE-free survival in ESRD patients undergoing CAPD (all p < 0.05), and high miR-130a expression at M0 was an independent factor for improved MACCE-free survival (p = 0.015; hazard ratio (HR) (95% confidential interval): 0.456 (0.243-0.857)). +lncRNA target 34708454 hsa-mir-130a Vascular Diseases BACKGROUND MicroRNA-130a (miR-130a) regulates angio-cellular dysregulation, atherosclerosis, and cardiocerebral injuries, serving as a biomarker for major adverse cardiovascular and cerebral events (MACCE) in several chronic diseases. +circulation_biomarker_diagnosis_ns 34708454 hsa-mir-130a Kidney Failure, Chronic METHODS miR-130a expression in peripheral blood mononuclear cells obtained from 50 healthy controls (HCs) at recruitment and 257 ESRD patients undergoing CAPD at month (M)0, M12, M24, and M36 was determined by reverse transcription-quantitative polymerase chain reaction. +lncRNA target 34708395 hsa-mir-370 Prostatic Neoplasms In summary, our study showed that lncRNA HCG18 accelerated cell proliferation, invasion, and migration of PC via up-regulating DDX3X through sponging miR +lncRNA target 34708341 hsa-let-7c Carcinoma, Transitional Cell CONCLUSIONS: Our results demonstrate that miR-Let-7c can act in different pathways of the carcinogenic cellular processes of muscle-invasive urothelial carcinoma cells, inhibiting cell proliferation and increasing apoptosis levels, consequently limiting their invasion potential. +exosome 34708038 hsa-mir-193a Nephrotic Syndrome Higher Urine Exosomal miR-193a Is Associated With a Higher Probability of Primary Focal Segmental Glomerulosclerosis and an Increased Risk of Poor Prognosis Among Children With Nephrotic Syndrome. +genetics_overexpression_promote 34707707 hsa-mir-216a Wounds and Injuries The present study aimed to investigate the role of miR-216a-5p in lipopolysaccharide (LPS)-induced endothelial injury in vitro. Taken together, the results suggest that overexpression of miR-216a-5p suppresses the effects of LPS induced endothelial injury. +transcription factor target 34707706 hsa-mir-142 Mastitis 5p may promote the progression of bovine mastitis via targeting BAG5. +target gene 34707704 hsa-mir-106a Adenocarcinoma of Lung MicroRNA-106a-5p promotes the proliferation, autophagy and migration of lung adenocarcinoma cells by targeting LKB1/AMPK. +genetics_overexpression_suppress 34707683 hsa-mir-18a Squamous Cell Carcinoma of Head and Neck Rescue experiments displayed that forced expression of SORBS2 restored the impact of miR-18a-5p overexpression on HNSCC cells. +other 34707644 hsa-let-7e Diabetes Mellitus, Type 2 Firstly, we found four characteristic miRNAs as signature by the SVM-RFE method (hsa-let-7E-5p, hsa-miR-30 days-5p, hsa-miR-199b-5p, and hsa-miR3p), called DMEDSig-4. +other 34707644 hsa-mir-342 Diabetes Mellitus, Type 2 Firstly, we found four characteristic miRNAs as signature by the SVM-RFE method (hsa-let-7E-5p, hsa-miR-30 days-5p, hsa-miR-199b-5p, and hsa-miR3p), called DMEDSig-4. +other 34707644 hsa-mir-342 Erectile Dysfunction, Diabetic Firstly, we found four characteristic miRNAs as signature by the SVM-RFE method (hsa-let-7E-5p, hsa-miR-30 days-5p, hsa-miR-199b-5p, and hsa-miR3p), called DMEDSig-4. +other 34707644 hsa-let-7e Erectile Dysfunction, Diabetic Firstly, we found four characteristic miRNAs as signature by the SVM-RFE method (hsa-let-7E-5p, hsa-miR-30 days-5p, hsa-miR-199b-5p, and hsa-miR3p), called DMEDSig-4. +other 34707644 hsa-mir-199b Erectile Dysfunction, Diabetic Firstly, we found four characteristic miRNAs as signature by the SVM-RFE method (hsa-let-7E-5p, hsa-miR-30 days-5p, hsa-miR-199b-5p, and hsa-miR3p), called DMEDSig-4. +other 34707644 hsa-mir-199b Diabetes Mellitus, Type 2 Firstly, we found four characteristic miRNAs as signature by the SVM-RFE method (hsa-let-7E-5p, hsa-miR-30 days-5p, hsa-miR-199b-5p, and hsa-miR3p), called DMEDSig-4. +lncRNA target 34707383 hsa-mir-4524a Atherosclerosis The top upregulated genes were involved in inflammation and atherosclerosis (chemokines, interleukin-6, selectin E and low-density lipoprotein cholesterol (LDL-C) receptor), whereas the downregulated genes were involved in cardiac ischaemia and remodelling, platelet function and mitochondrial function (miR-3671, miR-4524a, multimerin, biglycan, tissue factor pathway inhibitor (TFPI), glucuronidases, miR-548, collagen type I, III, IV). +lncRNA target 34707383 hsa-mir-4524a Coronary Artery Disease The top upregulated genes were involved in inflammation and atherosclerosis (chemokines, interleukin-6, selectin E and low-density lipoprotein cholesterol (LDL-C) receptor), whereas the downregulated genes were involved in cardiac ischaemia and remodelling, platelet function and mitochondrial function (miR-3671, miR-4524a, multimerin, biglycan, tissue factor pathway inhibitor (TFPI), glucuronidases, miR-548, collagen type I, III, IV). +lncRNA target 34707383 hsa-mir-548 Atherosclerosis The top upregulated genes were involved in inflammation and atherosclerosis (chemokines, interleukin-6, selectin E and low-density lipoprotein cholesterol (LDL-C) receptor), whereas the downregulated genes were involved in cardiac ischaemia and remodelling, platelet function and mitochondrial function (miR-3671, miR-4524a, multimerin, biglycan, tissue factor pathway inhibitor (TFPI), glucuronidases, miR-548, collagen type I, III, IV). +lncRNA target 34707383 hsa-mir-671 Coronary Artery Disease The top upregulated genes were involved in inflammation and atherosclerosis (chemokines, interleukin-6, selectin E and low-density lipoprotein cholesterol (LDL-C) receptor), whereas the downregulated genes were involved in cardiac ischaemia and remodelling, platelet function and mitochondrial function (miR-3671, miR-4524a, multimerin, biglycan, tissue factor pathway inhibitor (TFPI), glucuronidases, miR-548, collagen type I, III, IV). +lncRNA target 34707383 hsa-mir-548 Coronary Artery Disease The top upregulated genes were involved in inflammation and atherosclerosis (chemokines, interleukin-6, selectin E and low-density lipoprotein cholesterol (LDL-C) receptor), whereas the downregulated genes were involved in cardiac ischaemia and remodelling, platelet function and mitochondrial function (miR-3671, miR-4524a, multimerin, biglycan, tissue factor pathway inhibitor (TFPI), glucuronidases, miR-548, collagen type I, III, IV). +lncRNA target 34707383 hsa-mir-671 Atherosclerosis The top upregulated genes were involved in inflammation and atherosclerosis (chemokines, interleukin-6, selectin E and low-density lipoprotein cholesterol (LDL-C) receptor), whereas the downregulated genes were involved in cardiac ischaemia and remodelling, platelet function and mitochondrial function (miR-3671, miR-4524a, multimerin, biglycan, tissue factor pathway inhibitor (TFPI), glucuronidases, miR-548, collagen type I, III, IV). +lncRNA target 34707022 hsa-mir-515 Breast Neoplasms In summary, this study shows that circ_0103552 up-modulates CYR61 expression by targeting miR +other 34706869 hsa-mir-206 Carcinoma, Hepatocellular MicroRNA-206, by driving M1 polarisation of KCs, promoted the recruitment of CD8(+) T cells and prevented HCC, suggesting its potential use as an immunotherapeutic approach. +other 34706799 hsa-mir-5590 Nasopharyngeal Carcinoma SNHG14-miR 3p-ZEB1 positively regulated PD-L1 and facilitate the EMT of NPC. +other 34706761 hsa-mir-200 Colorectal Neoplasms Testing of paired CRC patient samples confirmed the positive regulatory relationship between MYSM1 and miR-200/CDH1. +genetics_GWAS 34706712 hsa-mir-146a Diabetes Mellitus, Type 2 RESULTS: There were no significant differences in the genotype or allele frequencies of the miR-146a polymorphism (rs2910164) between subjects with PDR and those without DR. +genetics_GWAS 34706712 hsa-mir-146a Diabetic Retinopathy RESULTS: There were no significant differences in the genotype or allele frequencies of the miR-146a polymorphism (rs2910164) between subjects with PDR and those without DR. +circulation_biomarker_diagnosis_up 34706645 hsa-mir-195 Colonic Neoplasms 5p in cytoplasm. +genetics_GWAS 34706275 hsa-mir-3682 Carcinoma, Hepatocellular CONCLUSIONS: This study implicates that miR-3682 plays an oncogenetic role in HCC and can be considered a novel therapeutic target and prognostic indicator of HCC. +genetics_knock down_suppress 34706132 hsa-mir-512 Adenocarcinoma of Lung 5p inhibition could reverse the effects of hsa_circ_0005576 knockdown in LUAD cells resistant to osimertinib. +circRNA target 34705617 hsa-mir-214 Carcinoma, Renal Cell Thus, hsa_circ_0065217/miR3p/ALPK2 signaling putatively promotes RCC tumorigenesis and is a putative RCC treatment target. +other 34705586 hsa-mir-19b Mobility Limitation The combine results of these three models identify miR-19b-3p as a potent regulator of muscle anabolism that may contribute to an inter-individual response to PRET in mobility-limited older adults. +transcription factor target 34705345 hsa-mir-124 Angelman Syndrome The miR3p/DLX5 axis might serve as a therapeutic molecular target to reverse the effect of ox-LDL and prevent atherosclerosis (AS) development and progression. +transcription factor target 34705345 hsa-mir-124 Cell Transformation, Neoplastic CONCLUSIONS The ox-LDL affects the VSMC proliferation/apoptosis balance via the miR3p/DLX5 axis, which results in VSMC hyperproliferation. +other 34705228 hsa-mir-1299 Adrenocorticotropic hormone deficiency CircLIFR and KDR were down-regulated and miR-1299 was up-regulated in the artery wall tissues and ASMCs of IA patients. Our findings suggest that circLIFR, an underexpressed circRNA in IA, can regulate the proliferation, migration, invasion and apoptosis of HUASMCs depending on the miR-1299/KDR axis. +epigenetics 34705180 hsa-mir-132 Breast Neoplasms 3p and the levels of methylation of the corresponding genes in breast cancer was showed by using Spearman's rank correlation test. +epigenetics 34705180 hsa-mir-129 Breast Neoplasms 3p and the levels of methylation of the corresponding genes in breast cancer was showed by using Spearman's rank correlation test. +epigenetics 34705180 hsa-mir-148a Breast Neoplasms 3p and the levels of methylation of the corresponding genes in breast cancer was showed by using Spearman's rank correlation test. +epigenetics 34705180 hsa-mir-375 Breast Neoplasms 3p and the levels of methylation of the corresponding genes in breast cancer was showed by using Spearman's rank correlation test. +genetics_overexpression_promote 34704918 hsa-mir-296 Uterine Cervical Neoplasms 5p counteracted the enhancing effects of overexpressed KCNQ1OT1 on the proliferative, migrative and invasive abilities of CC cells. +genetics_overexpression_promote 34704819 hsa-mir-188 Carcinoma, Hepatocellular MiR-3188 overexpression promoted cell viability and proliferation but inhibited the apoptosis of HCC cells. +lncRNA target 34704657 hsa-mir-53 Sjogren's Syndrome RESULTS: We successfully generated SSB-resistant rice (csu-53) expressing the artificial microRNA (amiRNA) of SSB endogenous miRNA (csu-novel-miR53) through the RNAi-based technology. CONCLUSION: amiRNA-mediated strategy can be applied to the development of insect-resistant crops, and the novel amiRNA csu-novel-miR53 of SSB has important application potential in developing SSB resistant rice. +genetics_overexpression_promote 34704601 hsa-mir-423 Colonic Neoplasms Intriguingly, overexpression of MFAP2 restrained si-KCNQ1OT1- or miR +genetics_knock down_promote 34704451 hsa-mir-1301 Thyroid Cancer, Papillary 3p overexpression inhibited the malignant effects of PTC cells via suppressing HMGB1. +genetics_knock down_promote 34704358 hsa-mir-150 Diabetes Mellitus We further delineated the critical cellular localization of phosphorylated ELK1 at serine 383 (pELK1(S383) ) and found that decreased miR-150 exacerbated the T2D-induced inflammation in photoreceptors by upregulating ELK1 and pELK1(S383) , and knockdown of ELK1 alleviated PA-elicited photoreceptor inflammation. +lncRNA target 34704284 hsa-mir-377 Hernias, Diaphragmatic, Congenital Expression of Concern: 'miR3p drives malignancy characteristics via upregulating GSK-3beta expression and activating NF-kappaB pathway in hCRC cells', by Wei-Ying Liu, Zhen Yang, Qi Sun, Xi Yang, Yang Hu, Hong Xie, Hui-Jie Gao, Li-Ming Guo, Jian-Ying Yi, Min Liu, and Hua Tang (2017); J Cell Biochem. +transcription factor target 34704004 hsa-mir-138 Hepatitis B, Chronic Thus, inhibiting hsa-miR5p expression should be considered in the combinatorial design of new therapies against HBV, especially in the context of immune-mediated A3B induction. +genetics_knock down_promote 34703899 hsa-mir-34b Carcinoma, Endometrioid Lastly, knockdown of miR-34b counteracted with the suppressive effects of ZFAS1 silence on endometrial carcinoma cell proliferation and metastasis. +lncRNA target 34703677 hsa-mir-155 Glomerulonephritis, Membranous RESULTS: Two miRNA-mRNA pairs, miR5p-FOS and miR-146a-5p-BTG2, were differentially expressed in IMN, indicating that these genes may affect IMN through immune processes. +lncRNA target 34703677 hsa-mir-146a Glomerulonephritis, Membranous RESULTS: Two miRNA-mRNA pairs, miR5p-FOS and miR-146a-5p-BTG2, were differentially expressed in IMN, indicating that these genes may affect IMN through immune processes. +other 34703649 hsa-mir-370 Carcinoma, Hepatocellular In addition, we demonstrated that circHPS5 can act as a miR-370 sponge to regulate the expression of HMGA2 and further accelerate HCC cell tumorigenesis. +other 34703648 hsa-mir-16-1 Urinary Bladder Neoplasms 1-3p/MDM2/p53 axis. +other 34703647 hsa-mir-146b Adenocarcinoma of Lung RNA precipitation assays, western blotting, luciferase assays, and rescue experiments demonstrated that HIF1A-AS2 sponged microRNA-146b-5p (miR-146b-5p), promoting interleukin-6 (IL-6) expression, activating the IL-6/STAT3 pathway, and leading to LUAD progression. miR-146b-5p and IL-6 levels were correlated with the prognosis of LUAD patients. +genetics_overexpression_promote 34703308 hsa-mir-10a Urinary Bladder Neoplasms In addition, overexpression of miR-10a-5p could promote BCa cell proliferation, migration, and invasion. +other 34703286 hsa-mir-1245a Sarcopenia CONCLUSION: Our analyses indicate that miRNA-1245a may be a potential key molecule in the diagnosis and treatment of sarcopenia, which provides a basis for the research of miRNA in sarcopenia. +transcription factor target 34703270 hsa-mir-155 Asthma CONCLUSION: SJMHE1 regulated the balance of Th17 and Treg cells by modulating the activation of STAT3 and STAT5 via miR-155 in asthma. +circulation_biomarker_prognosis_up 34703259 hsa-mir-34c Diabetes Mellitus, Type 2 CONCLUSION: The increased expression of miR-34c in peripheral blood of T2DM patients is closely related to the occurrence, development and prognosis of DFU and DFO. +circulation_biomarker_prognosis_up 34703259 hsa-mir-34c Diabetic Foot CONCLUSION: The increased expression of miR-34c in peripheral blood of T2DM patients is closely related to the occurrence, development and prognosis of DFU and DFO. +transcription factor target 34703235 hsa-mir-448 Brain Ischemia 3p participated in the regulation of cerebral I/R injury via inhibiting Nrf2. +epigenetics 34702271 hsa-mir-23b Squamous Cell Carcinoma of Head and Neck Hypomethylation and downregulation of miR-23b-3p might account for the oncogenic role of PLAU in HNSCC. +lncRNA target 34702201 hsa-mir-490 Urinary Bladder Neoplasms CONCLUSIONS: Our study revealed that LINC00958 facilitated cell proliferation and invasion, and suppressed cell apoptosis by sponging miR +circulation_biomarker_diagnosis_down 34702176 hsa-mir-375 Carotid Stenosis RESULTS The expression level of serum miR +circulation_biomarker_prognosis_up 34702084 hsa-mir-124 Cerebral Infarction, Acute miR-124 was poorly expressed in the serum of ACI patients and served as a biomarker for the diagnosis and prognosis. +genetics_overexpression_suppress 34699986 hsa-mir-221 Carcinoma, Hepatocellular Overexpressing miR +other 34699756 hsa-mir-22 Atherosclerosis Collectively, SNHG16 accelerated atherosclerotic plaque (AP) formation and enhanced ox-LDL-activated VSMCs proliferation and migration by miRNA3p/HMGB2 axis. +lncRNA target 34699621 hsa-mir-21 Carcinoma, Renal Cell Inhibiting the expression levels of microRNA-765, microRNA-21, and microRNA-144 can reduce the proliferation, EMT, and invasion of RCC cells. +lncRNA target 34699621 hsa-mir-765 Carcinoma, Renal Cell Inhibiting the expression levels of microRNA-765, microRNA-21, and microRNA-144 can reduce the proliferation, EMT, and invasion of RCC cells. +lncRNA target 34699621 hsa-mir-144 Carcinoma, Renal Cell Inhibiting the expression levels of microRNA-765, microRNA-21, and microRNA-144 can reduce the proliferation, EMT, and invasion of RCC cells. +lncRNA target 34699325 hsa-mir-934 Colorectal Neoplasms In summary, this study suggests that miR-934 facilitates CRC progression by targeting BTG2, and further highlights the role of miR-934 in pathogenesis of CRC. +genetics_knock down_promote 34699320 hsa-mir-375 Esophageal Squamous Cell Carcinoma Further study showed that sestrin 3 (SESN3) could interact with miR-375, and its knockdown annulled the stimulative effect of miR-375 inhibitor on ESCC development. +genetics_overexpression_promote 34699315 hsa-mir-4521 Breast Neoplasms Overexpression of miR-4521 suppressed the growth, migration, invasion and cell cycle progression of BC cells and restrained p65 expression; downregulation of miR-4521 in BC cells showed opposite biological effects. +lncRNA target 34699311 hsa-mir-335 Asthma 5p alleviate inflammatory response, airway fibrosis, and autophagy in childhood asthma through targeted regulation of ATG5. +lncRNA target 34699311 hsa-mir-335 Fibrosis, Airway 5p alleviate inflammatory response, airway fibrosis, and autophagy in childhood asthma through targeted regulation of ATG5. +other 34698882 hsa-mir-409 Obesity 3p as a critical regulator of EC-BAT crosstalk by modulating a ZEB1-MAP4K3-PLGF signaling axis, providing new insights for therapeutic intervention in obesity. +circulation_biomarker_diagnosis_ns 34698812 hsa-mir-1246 Dermatomyositis DM plasma EXOs can induce autophagy in HSkMCs by regulating three miRNAs (hsa-miR-125a-3p, hsa-miR-1246 and hsa-miR5p) and three lncRNAs (ENST00000584157.1, ENST00000523380.1 and ENST00000560054.1), which formed an autophagy network, playing a role in muscle damage. +circulation_biomarker_diagnosis_ns 34698812 hsa-mir-125a Dermatomyositis DM plasma EXOs can induce autophagy in HSkMCs by regulating three miRNAs (hsa-miR-125a-3p, hsa-miR-1246 and hsa-miR5p) and three lncRNAs (ENST00000584157.1, ENST00000523380.1 and ENST00000560054.1), which formed an autophagy network, playing a role in muscle damage. +circulation_biomarker_diagnosis_ns 34698812 hsa-mir-614 Dermatomyositis DM plasma EXOs can induce autophagy in HSkMCs by regulating three miRNAs (hsa-miR-125a-3p, hsa-miR-1246 and hsa-miR5p) and three lncRNAs (ENST00000584157.1, ENST00000523380.1 and ENST00000560054.1), which formed an autophagy network, playing a role in muscle damage. +circulation_biomarker_diagnosis_ns 34698413 hsa-mir-21 Encephalitis, Japanese We have found significantly altered expression of miR-155 and miR-21 in serum of JEV infected patients as compared to healthy controls, revealing their role as a a noninvasive biomarker in JE. +circulation_biomarker_diagnosis_ns 34698413 hsa-mir-155 Encephalitis, Japanese We have found significantly altered expression of miR-155 and miR-21 in serum of JEV infected patients as compared to healthy controls, revealing their role as a a noninvasive biomarker in JE. +lncRNA target 34698372 hsa-mir-185 Asthma 5p is a modulator of periostin secretion by airway structural cells and of smooth muscle contraction, which can be related to asthma pathophysiology, and thus, might be a promising therapeutic target. +lncRNA target 34698362 hsa-mir-223 Atrial Fibrillation A ceRNA regulatory relationship may exist between KCNQ1OT1 and miR2233p in AF, providing therefore a novel potential research target for further studies. +lncRNA target 34698360 hsa-mir-18a Lymphoma, Large B-Cell, Diffuse On the whole, the present study demonstrates that GAS5 functions as a ceRNA, inhibiting DLBCL cell proliferation by sponging miR18a5p to upregulate RUNX1 expression. +transcription factor target 34698359 hsa-mir-149 Prostatic Neoplasms, Castration-Resistant The miR149/Akt1/AR regulatory pathway may represent a novel PCa therapeutic target. +other 34698358 hsa-mir-195 Prostatic Neoplasms Furthermore, miR1955p may regulate PCa cell proliferation and invasion by regulating MIB1, indicating its potential therapeutic application for PCa in the future. +genetics_knock down_promote 34698001 hsa-mir-218 Squamous Cell Carcinoma of Head and Neck 5p reversed the inhibitory effect of HOXA-AS3 knockdown on the proliferative potential of OSCC cells. +genetics_knock down_promote 34698000 hsa-mir-409 Breast Neoplasms In addition, overexpression of circCNOT2 or TWIST1 accelerated BC invasion, migration and EMT, which could be reversed by simultaneous transfection of miR +lncRNA target 34697900 hsa-mir-212 Prostatic Neoplasms Rescue experiments further showed that LINC00115 inhibits prostate cancer cell proliferation and invasion via targeting miR5p/ FZD5/ Wnt/beta-catenin axis. +other 34697773 hsa-mir-7 Nerve Degeneration Collectively, these findings support the potential of miR-7 as a disease modifying biologic agent for Parkinson's disease and related alpha-synucleinopathies. +lncRNA target 34697729 hsa-mir-337 Osteoarthritis 3p exerted a protective effect on FJOA rats by alleviating damage of rat synovial tissues, promoting cell apoptosis and repressing inflammatory response. +other 34697541 hsa-mir-138 Stomach Neoplasms The LINC00152/miR-138 Axis Facilitates Gastric Cancer Progression by Mediating SIRT2. +lncRNA target 34697449 hsa-mir-199a Carcinoma, Squamous Cell, Cutaneous In conclusion, HOTAIR, by up-regulating Sp1 and targeting miR-199a, promotes stemness and progression of CSCC. +other 34697403 hsa-mir-4458 Stomach Neoplasms In conclusion, LINC00963 and miR-4458 are potential biomarkers for predicting the overall survival of gastric cancer patients. +lncRNA target 34697393 hsa-mir-181a lung squamous cell carcinoma DLX6-AS1 induced by H3K4me1 played an important role in promoting secondary cisplatin resistance of LUSC through regulating the miR-181a-5p/miR +lncRNA target 34697393 hsa-mir-382 lung squamous cell carcinoma DLX6-AS1 induced by H3K4me1 played an important role in promoting secondary cisplatin resistance of LUSC through regulating the miR-181a-5p/miR +lncRNA target 34696938 hsa-mir-29c Oral Submucous Fibrosis The purpose of the study is to investigate the functional role of miR-29c and its target in OSF. +other 34696757 hsa-mir-184 Shoulder Injuries RESULTS: Microarray and qPCR analyses showed that miR-184 and miR-203 were expressed significantly more highly in tears than in sera (165,542.8- and 567.8-fold, respectively, p < 0.05). +lncRNA target 34696757 hsa-mir-203 Shoulder Injuries RESULTS: Microarray and qPCR analyses showed that miR-184 and miR-203 were expressed significantly more highly in tears than in sera (165,542.8- and 567.8-fold, respectively, p < 0.05). CONCLUSIONS: In this study, we identified miRNAs that are highly expressed in tears, and the inhibition of miR-203 increases the viability of corneal epithelial cells. +transcription factor target 34696703 hsa-mir-34 Cholesteatoma, Middle Ear It can passively target tumor tissue through EPR effect, and play its regulatory role on miR-34a, thus inhibiting the growth of cholesteatoma cells. +transcription factor target 34696703 hsa-mir-34a Cholesteatoma, Middle Ear It can passively target tumor tissue through EPR effect, and play its regulatory role on miR-34a, thus inhibiting the growth of cholesteatoma cells. +lncRNA target 34696702 hsa-mir-485 Pre-Eclampsia In conclusion, silencing of NEAT1 promoted Treg/Th17 balance via the miR5p/AIM2 axis in PE, suggesting that NEAT1 is a potential target for the treatment of PE. +genetics_overexpression_promote 34696684 hsa-mir-4423 Arthritis, Rheumatoid The overexpression of miR +circulation_biomarker_diagnosis_up 34696681 hsa-mir-138 Stomach Neoplasms 5p to upregulate PLAU could contribute to GAC progression, which might be useful for identifying biomarkers for GAC therapy.AbbreviationGastric adenocarcinoma (GAC); Long non-coding RNA (lncRNA); lncRNA TRPM2 antisense RNA (TRPM2-AS); Plasminogen Activator, Urokinase (PLAU); Wild-type (WT); mutant (MUT). +genetics_overexpression_promote 34696668 hsa-mir-150 Nasopharyngeal Neoplasms The overexpression of hsa-miR +genetics_overexpression_promote 34696664 hsa-mir-145 Osteosarcoma Our results demonstrate that the overexpression of lncRNA SOX21-AS1 up-regulates mTOR and KLF4 by sponging hsa-mir +genetics_overexpression_promote 34696664 hsa-mir-7 Osteosarcoma Our results demonstrate that the overexpression of lncRNA SOX21-AS1 up-regulates mTOR and KLF4 by sponging hsa-mir +genetics_overexpression_promote 34696660 hsa-mir-130a Stomach Neoplasms While miR-130a-3p mimics facilitated cellular proliferation, migration, and invasion in vitro, promoted tumor growth in vivo, and activated the TGF-beta1/SMAD3 signaling pathway, overexpression of GCNT4 prevented the growth of gastric cancer cells and restrained the activation of the TGF-beta1/SMAD3 pathway. +transcription factor target 34696659 hsa-mir-326 Carcinoma, Non-Small-Cell Lung MiR-326 inhibited the proliferation of chemotherapy-resistant NSCLC cells and promoted their apoptosis by suppressing SIRT1. +circulation_biomarker_diagnosis_ns 34696438 hsa-mir-135a Carcinoma, Hepatocellular In conclusion: serum IL-13, Vitamin D, and miRNA-135a could be potential biomarkers in monitoring DAA treatment and HCC prediction. +genetics_knock down_promote 34695896 hsa-mir-367 Ovarian Neoplasms Conclusion: Knockdown of circBIRC6 may inhibit the proliferation of ovarian cancer cisplatin-resistant cells and induce apoptosis by up-regulating the expression of miR +lncRNA target 34695805 hsa-mir-20a Precursor T-Cell Lymphoblastic Leukemia-Lymphoma We validated that the treatment of miR-20a-5p mimic inhibited the viability of T-ALL cells. +other 34695419 hsa-mir-27a Neoplasms, Second Primary Particularly, miR-27a-3p has been shown to play a critical role in the regulation of P-gp in multi-drug resistant cancer cells. +other 34695419 hsa-mir-27a Brain Diseases In brain disorders, altered levels of miR-27a-3p were reported in several diseases associated with alterations in P-gp expression at the BBB. +other 34695419 hsa-mir-27a Central Nervous System Diseases These findings shed light on miR-27a-3p/GSK3ss/ss-catenin as a novel axis that could be exploited to modulate P-gp efflux activity at the brain endothelium and help improving CNS diseases treatment or brain protection. +other 34695419 hsa-mir-27a Genetic Diseases, Inborn Particularly, miR-27a-3p has been shown to play a critical role in the regulation of P-gp in multi-drug resistant cancer cells. +other 34695392 hsa-mir-128 Diabetic Neuropathies Based on these results, we speculated that a newly identified circRNA, circ-Nbea, may play an important role in the development of DE, and the mechanism is mediated by sponging miR3p. +other 34695390 hsa-mir-16 Liver Diseases Here, we evaluated Cel-miR3p and miRNA16-5p as calibrator for the quantification of 15 miRNAs linked to hepatic impairment. +other 34695177 hsa-mir-143 Carcinoma, Non-Small-Cell Lung These results demonstrated that the LINC01296/miR3p/ATG2B axis is crucial in promoting the development of NSCLC and paclitaxel resistance. +other 34695034 hsa-mir-93 Crohn Disease 5p) were selected for discriminating between the 2 patient groups at presurgery (PS), with an area under the curve of 0.88 (95% confidence interval [0.79, 0.98]). +other 34695034 hsa-mir-106b Crohn Disease 5p) were selected for discriminating between the 2 patient groups at presurgery (PS), with an area under the curve of 0.88 (95% confidence interval [0.79, 0.98]). +other 34695034 hsa-mir-451a Crohn Disease 5p) were selected for discriminating between the 2 patient groups at presurgery (PS), with an area under the curve of 0.88 (95% confidence interval [0.79, 0.98]). +other 34695034 hsa-mir-15b Crohn Disease 5p) were selected for discriminating between the 2 patient groups at presurgery (PS), with an area under the curve of 0.88 (95% confidence interval [0.79, 0.98]). +other 34695034 hsa-mir-191 Crohn Disease 5p) were selected for discriminating between the 2 patient groups at presurgery (PS), with an area under the curve of 0.88 (95% confidence interval [0.79, 0.98]). +lncRNA target 34694758 hsa-let-7i Acute Kidney Injury In conclusion, miR-let-7i could be an interesting therapeutic target and nanoparticle-based DIO could be a potential candidate in the management of acute kidney injury. +exosome 34694648 hsa-mir-126 Wounds and Injuries Rats with full-thickness skin defects were injected with ADSC-Exos or exosomes extracted from ADSCs transfected with miR +circRNA target 34694278 hsa-mir-409 Carcinoma, Non-Small-Cell Lung 3p inhibitors could partially reverse these impacts. +transcription factor target 34694211 hsa-mir-101 Carcinoma, Non-Small-Cell Lung 3p may act as a potential therapeutic target for the treatment of NSCLC. +circRNA target 34693745 hsa-mir-6817 Bone Diseases Collectively, circRFWD2/miR5p/BMPR2 axis could regulate DPSCs osteogenesis via BMP-Smad and p38 MAPK pathway, which are novel mechanisms in the osteogenic differentiation of DPSCs and suggest potential therapeutic methods for bone defects regeneration. +lncRNA target 34693428 hsa-mir-32 Bone Diseases Compared with EMPs group, the expression of DSPP and DMP-1 and the number of mineralized nodules in EMPs+miR-32 inhibitor group were significantly reduced(P<0.05), while the expression of PPARgamma and C/EBPalpha and the number of lipid droplets were significantly increased(P<0.05). +genetics_overexpression_promote 34693046 hsa-mir-142 Squamous Cell Carcinoma of Head and Neck Overexpression of miR +lncRNA target 34692852 hsa-mir-129 Uterine Cervical Neoplasms 5p/BST2 as a new potential target for cervical cancer. +other 34692839 hsa-mir-107 Familial Mediterranean Fever 5p were downregulated in the FMF patients. +other 34692839 hsa-mir-1304 Familial Mediterranean Fever 5p were downregulated in the FMF patients. +other 34692839 hsa-mir-216a Familial Mediterranean Fever 5p were downregulated in the FMF patients. +other 34692839 hsa-mir-569 Familial Mediterranean Fever 5p were downregulated in the FMF patients. +other 34692839 hsa-mir-340 Familial Mediterranean Fever 5p were downregulated in the FMF patients. +other 34692839 hsa-mir-34a Familial Mediterranean Fever 5p were downregulated in the FMF patients. +other 34692839 hsa-mir-142 Familial Mediterranean Fever 5p were downregulated in the FMF patients. +genetics_overexpression_promote 34692524 hsa-mir-150 Osteosarcoma Overexpression of miR +circulation_biomarker_diagnosis_up 34692511 hsa-mir-18a Nasopharyngeal Carcinoma METHODS: Expression levels of miR-18a-3p in platelets and plasma were detected by relative quantitative real-time PCR in NPC patients (n=54) and normal subjects (n=36). +genetics_overexpression_promote 34692507 hsa-mir-587 Stomach Neoplasms Overexpression of circ-0002570 prevented VCAN from miR +transcription factor target 34692488 hsa-mir-183 Carcinoma, Renal Cell 5p/FOXO4 axis played essential role in promoting ccRCC progression, which suggests that disruption of this axis may be a potential therapeutic target in ccRCC. +circulation_biomarker_diagnosis_ns 34692473 hsa-mir-205 Carcinoma, Ovarian Epithelial In addition, the miRNA panel (miR-205 + miR-200c + miR-141) has a much higher AUC, sensitivity, and specificity to predict EOC at an early stage in both tissue and serum samples. +circulation_biomarker_diagnosis_ns 34692473 hsa-mir-200c Carcinoma, Ovarian Epithelial In addition, the miRNA panel (miR-205 + miR-200c + miR-141) has a much higher AUC, sensitivity, and specificity to predict EOC at an early stage in both tissue and serum samples. +circulation_biomarker_diagnosis_ns 34692473 hsa-mir-141 Carcinoma, Ovarian Epithelial In addition, the miRNA panel (miR-205 + miR-200c + miR-141) has a much higher AUC, sensitivity, and specificity to predict EOC at an early stage in both tissue and serum samples. +circulation_biomarker_diagnosis_up 34692380 hsa-mir-434 Sarcopenia Circulating miR-21 levels were higher and miR-181a, miR-133a, miR +circulation_biomarker_diagnosis_up 34692380 hsa-mir-133a Heart Failure, Chronic METHODS: We analyzed the association of circulating microRNAs (miRs) levels including miR-21, miR +circulation_biomarker_diagnosis_up 34692380 hsa-mir-133a Sarcopenia METHODS: We analyzed the association of circulating microRNAs (miRs) levels including miR-21, miR +circulation_biomarker_diagnosis_up 34692380 hsa-mir-455 Sarcopenia METHODS: We analyzed the association of circulating microRNAs (miRs) levels including miR-21, miR +circulation_biomarker_diagnosis_up 34692380 hsa-mir-455 Heart Failure, Chronic METHODS: We analyzed the association of circulating microRNAs (miRs) levels including miR-21, miR +circulation_biomarker_diagnosis_up 34692380 hsa-mir-434 Heart Failure, Chronic Circulating miR-21 levels were higher and miR-181a, miR-133a, miR +genetics_knock down_promote 34691259 hsa-mir-3907 Adenocarcinoma, Sebaceous, Eyelid Furthermore, THBS1 overexpression was found to attenuate the stimulative effect of miR-3907 mimics, and THBS1-knockdown reversed the inhibitory effect of the miR-3907 inhibitor in SGC cells. +lncRNA target 34691252 hsa-mir-136 Endometrial Neoplasms 5p, which may improve the understanding of the roles of ncRNAs in EC, and may help identify novel targets for anticancer treatment. +exosome 34691188 hsa-mir-146a Sepsis CONCLUSION: This study suggests that miR-146a-5p-bearing MSC-derived exosomes may become an effective treatment for sepsis. +lncRNA target 34691176 hsa-mir-1278 Squamous Cell Carcinoma of Head and Neck Mechanistically, circPTK2 functioned as a molecular sponge of miR-1278 to upregulate YAP1 expression in LSCC cells. Therefore, we concluded that circPTK2 facilitates LSCC progression through the miR-1278/YAP1 axis. +other 34691148 hsa-mir-124 Duane Retraction Syndrome 3p in high glucose (HG)-treated human retinal microvascular endothelial cells (HRMECs), an in vitro model of DR. +other 34691048 hsa-mir-26a Diabetes Mellitus, Type 1 Real-time qPCR validation confirmed that hsa-miR-146a-5p, hsa-miR-26a-5p, hsa-miR3p, and hsa-miR-30d-5p were significantly upregulated in lactating mothers with type 1 diabetes as compared to lactating healthy mothers. +other 34691048 hsa-mir-146a Diabetes Mellitus, Type 1 Real-time qPCR validation confirmed that hsa-miR-146a-5p, hsa-miR-26a-5p, hsa-miR3p, and hsa-miR-30d-5p were significantly upregulated in lactating mothers with type 1 diabetes as compared to lactating healthy mothers. +other 34691048 hsa-mir-24 Diabetes Mellitus, Type 1 Real-time qPCR validation confirmed that hsa-miR-146a-5p, hsa-miR-26a-5p, hsa-miR3p, and hsa-miR-30d-5p were significantly upregulated in lactating mothers with type 1 diabetes as compared to lactating healthy mothers. +other 34690655 hsa-mir-1 Squamous Cell Carcinoma of Head and Neck This study aims to examine the miR-31 expression in the pre- and post-operative OSCC patients and correlate this expression with clinicopathological characteristics. CONCLUSION: Our data suggest that miR-31 can be used as an adjunct non-invasive marker to monitor surgery outcomes during postoperative follow-up in patients with OSCC. +other 34690249 hsa-mir-140 Periodontitis 5p and miR-146a-5p were associated with PD and would be potentially effective for GCF-based non-invasive periodontitis diagnostics in patients with and without RA. +other 34690249 hsa-mir-145 Periodontitis 5p and miR-146a-5p were associated with PD and would be potentially effective for GCF-based non-invasive periodontitis diagnostics in patients with and without RA. +other 34690249 hsa-mir-146a Periodontitis 5p and miR-146a-5p were associated with PD and would be potentially effective for GCF-based non-invasive periodontitis diagnostics in patients with and without RA. +genetics_overexpression_suppress 34690112 hsa-mir-181b Ovarian Neoplasms The SCD1 overexpression and miR-181b-5p inhibitor could reverse exosomal SOX2-OT-mediated ovarian cancer progression. +genetics_overexpression_promote 34689819 hsa-mir-195 Thyroid Cancer, Papillary 5p overexpressed PTC cells and tumor xenografts, whereas CircRNA NRIP1 up-regulation overturned the impacts. +lncRNA target 34689806 hsa-mir-124 Glioma 3p/KIF20A nexus, thus providing novel predictive/prognostic biomarkers and drug targets against glioma. +exosome 34689803 hsa-mir-155 Multiple Myeloma OBJECTIVE: This study was to explore the effect of exosomal miR-155 derived from bone marrow mesenchymal stem cells (BMSCs) on stemness maintenance and drug resistance in MPC-11 multiple myeloma cells. CONCLUSION: Therefore, our findings indicate that exosomal delivery of miR-155 exerted the same effect as transfection did on the stemness maintenance and drug resistance of multiple myeloma cells. +other 34689723 hsa-mir-152 Nephrotic Syndrome But miRNA- 152-3p has inadequate prognostic indicator for ESRD progression. +other 34689723 hsa-mir-152 Diabetes Mellitus, Type 2 But miRNA- 152-3p has inadequate prognostic indicator for ESRD progression. +exosome 34689576 hsa-mir-1275 Prostatic Neoplasms Our findings indicate that PCa-derived exosomal miR-1275 promotes the proliferation and activity of osteoblasts via modulation of SIRT2/Runx2 signaling. +other 34689283 hsa-mir-130b Coronary Artery Disease Hsa-miR-18a-3p and hsa-miR-130b-5p might serve as biomarkers of CAD development and progression and warrant further attention. +transcription factor target 34689283 hsa-mir-18a Coronary Artery Disease Computational prediction of target genes indicated a relevant role of hsa-miR-130b-5p and hsa-miR-18a-3p in modulating the expression of genes associated with cardiovascular diseases. +other 34689169 hsa-mir-27a Glioma These results demonstrated that the lncRNA TMEM161B-AS1-hsa-miR-27a-3p-FANCD2/CD44 signal axis regulated the malignant biological behavior of GBM and TMZ resistance. +lncRNA target 34689155 hsa-mir-142 Osteosarcoma To sum up, our study sheds light on the critical role of the oncogenic circ_0004674/miR5p/MCL1 axis in OS progression and chemoresistance, providing a novel potential target for OS therapy. +genetics_overexpression_suppress 34689058 hsa-mir-18a Diabetic Retinopathy Additionally, miR-18a-3p overexpression alleviated BRB injury to inhibit DR progression in vivo. +genetics_GWAS 34688806 hsa-mir-133b Pain, Postoperative Similarly, genetic overexpression of miR-133b-3p in the VPL reversed the allodynia established in CPSP rats via downregulation of P2X4R expression. +genetics_overexpression_promote 34688515 hsa-mir-425 Fibrosis, Atrial 5p could promote atrial remodeling, and overexpression of miR +genetics_overexpression_promote 34688515 hsa-mir-425 Atrial Fibrillation 5p could promote atrial remodeling, and overexpression of miR +other 34688465 hsa-mir-122 Inflammation The reverse transcription-polymerase chain reaction (RT-PCR) was used to examine the levels of microRNA-122 (miR-122) and genes related to inflammation, apoptosis, cell proliferation and liver function. RT-PCR results showed that the expression of miR-122 significantly decreased by GTW; the mRNA levels of inflammation-related genes il1beta, il6, tnfalpha, il10, cox2 and ptges significantly increased; the mRNA level of tgfbeta significantly decreased; the mRNA levels of apoptosis-related genes, caspase-8 and caspase-9, significantly increased; the mRNA level of bcl2 significantly decreased; the mRNA levels of cell proliferation-related genes, top2alpha and uhrf1, significantly reduced; the mRNA levels of liver function-related genes, alr and cyp3c1, significantly increased; and the mRNA level of cyp3a65 significantly decreased. +genetics_overexpression_promote 34688334 hsa-mir-375 Uterine Cervical Neoplasms This study attempted to investigate the impact of overexpressed miR +lncRNA target 34688330 hsa-mir-155 Uterine Cervical Neoplasms The composite NPs suppressed malignant characteristics of CC cells through down-regulation of miR-155 and activation of Tim-3 signal pathway on the surface of macrophages, promoting secretion of macrophage inflammatory factors. +other 34688135 hsa-mir-124 Neurogenic Inflammation miR-124 is ubiquitously expressed in the nervous tissue and acts as a negative regulator of neuroinflammation. +genetics_knock down_suppress 34687491 hsa-mir-98 Acute Lung Injury Our study demonstrated that NEAT1 knockdown alleviated LPS-induced ALI by targeting the miR +transcription factor target 34687270 hsa-mir-485 Lung Neoplasms The present study discovered that CDK16, whose expression is under the regulation of APA and miR5p, is a potential target for prosenescence therapy for lung cancer. +epigenetics 34687205 hsa-mir-200c Prostatic Neoplasms Survey of the PRAD-TCGA dataset shows that patients expressing an EMT-like signature are indeed characterized by down-regulation of the same miRNAs with a diffused hyper-methylation at miR-200c/141 and miR-200a/200b/429 promoters. +epigenetics 34687205 hsa-mir-429 Prostatic Neoplasms Survey of the PRAD-TCGA dataset shows that patients expressing an EMT-like signature are indeed characterized by down-regulation of the same miRNAs with a diffused hyper-methylation at miR-200c/141 and miR-200a/200b/429 promoters. +epigenetics 34687205 hsa-mir-141 Prostatic Neoplasms Survey of the PRAD-TCGA dataset shows that patients expressing an EMT-like signature are indeed characterized by down-regulation of the same miRNAs with a diffused hyper-methylation at miR-200c/141 and miR-200a/200b/429 promoters. +lncRNA target 34687205 hsa-mir-1260a Prostatic Neoplasms Finally, we show that miR-1260a also targets DNMT3A, although it does not seem to be involved in EMT in PCa. +genetics_overexpression_suppress 34687203 hsa-mir-99a Thyroid Cancer, Papillary Moreover, GRP94 overexpression reverses the inhibitory effect of miR-99a-3p on PTC metastasis. +transcription factor target 34687158 hsa-mir-34a Obesity sabdariffa has the potential to reduce FGF21 resistance in DIO rats through the suppression of miR-34a expression and an increase in the number of FGFR1 and beta-klotho receptors in adipose tissue. +genetics_GWAS 34687039 hsa-mir-221 Glioma Furthermore, the miR-221/222 cluster acts as an epigenetic brake during glioma differentiation. +genetics_GWAS 34687039 hsa-mir-222 Glioma Furthermore, the miR-221/222 cluster acts as an epigenetic brake during glioma differentiation. +other 34687038 hsa-mir-21 Vitiligo 5p in L skin leads to significantly higher levels of PDCD4 and Maspin, delaying wound re-epithelialization by reducing the proliferation and migration of keratinocytes. +exosome 34686767 hsa-mir-137 Schizophrenia "EPP can be stratified in two subgroups: (a) a patients' group with mitochondrial dysfunction ""Psy-D"", having high miR-137 and low COX6A2 levels in exosomes, and (b) a ""Psy-ND"" subgroup with no/low mitochondrial impairment, including patients having miR-137 and COX6A2 levels in the range of controls." +genetics_knock down_suppress 34686662 hsa-mir-370 Carcinoma, Hepatocellular Furthermore, knockdown of circUBE2J2 in HCC could downregulate KLF7, the target of miR +circulation_biomarker_diagnosis_ns 34686514 hsa-mir-208 Heart Diseases, Congenital CONCLUSION: The expression levels of miRNA-1, miRNA-208, and miRNA-499 in umbilical cord blood may be useful for predicting fetal CHD. +circulation_biomarker_diagnosis_ns 34686514 hsa-mir-1 Heart Diseases, Congenital CONCLUSION: The expression levels of miRNA-1, miRNA-208, and miRNA-499 in umbilical cord blood may be useful for predicting fetal CHD. +circulation_biomarker_diagnosis_ns 34686514 hsa-mir-499 Heart Diseases, Congenital CONCLUSION: The expression levels of miRNA-1, miRNA-208, and miRNA-499 in umbilical cord blood may be useful for predicting fetal CHD. +lncRNA target 34686506 hsa-mir-124 Colonic Neoplasms CONCLUSION: The expression of miR-124 inhibited cell proliferation, suppressed tumor cell migration and invasion, and enhanced apoptosis by its regulation of the expression of TET1, TET2, vimentin, and MMP-2 in colon cancer HT29 cells. +other 34686505 hsa-let-7a Lung Neoplasms CONCLUSION: This prospective study demonstrated that let-7a was correlated with tumor proliferation in lung cancer, with high prognostic value. Furthermore, it showed that repopulation, as correlated with let-7a, may exist during chemotherapy, which would give us a new perspective in overcoming the chemoresistance of lung cancer and would help in determining individual treatment strategies. +lncRNA target 34686504 hsa-mir-145 Carcinoma, Non-Small-Cell Lung The miR 145-5p-NRAS/MEST axis in NSCLC provides insights for the development of a NRAS/MEST targeting therapeutic approach to overcome gefitinib resistance in NSCLC patients. +exosome 34686196 hsa-mir-486 Stomach Neoplasms 5p via exosomes might be responsible for the peritoneal metastasis of gastric cancer cells by promoting epithelial-mesenchymal transition progress. +genetics_overexpression_promote 34686190 hsa-mir-425 Ovarian Neoplasms 5p overexpression in OC is negatively regulated by MAGI2-AS3. +other 34686186 hsa-mir-145 Stomach Neoplasms RESULTS: We got five miRNAs, including miR-23b, miR-100, miR-143, miR-145, and miR-409, which are associated with the overall survival of GC patients. +other 34686186 hsa-mir-23b Stomach Neoplasms RESULTS: We got five miRNAs, including miR-23b, miR-100, miR-143, miR-145, and miR-409, which are associated with the overall survival of GC patients. +other 34686186 hsa-mir-143 Stomach Neoplasms RESULTS: We got five miRNAs, including miR-23b, miR-100, miR-143, miR-145, and miR-409, which are associated with the overall survival of GC patients. +other 34686186 hsa-mir-100 Stomach Neoplasms RESULTS: We got five miRNAs, including miR-23b, miR-100, miR-143, miR-145, and miR-409, which are associated with the overall survival of GC patients. +other 34686186 hsa-mir-409 Stomach Neoplasms RESULTS: We got five miRNAs, including miR-23b, miR-100, miR-143, miR-145, and miR-409, which are associated with the overall survival of GC patients. +other 34685705 hsa-mir-25 Obesity 3p may be a critical mediator between obesity and muscle wasting. +other 34685705 hsa-mir-25 Muscular Atrophy 3p may be a critical mediator between obesity and muscle wasting. +other 34685557 hsa-mir-185 Arrhythmogenic Right Ventricular Dysplasia We found miR5p significantly upregulated in ARVC patients. +genetics_overexpression_promote 34685526 hsa-mir-21 psoriasis 1 3p overexpression in KCs. +lncRNA target 34685504 hsa-mir-491 Triple Negative Breast Neoplasms 5p and RABIF are potential prognostic biomarkers and targeting the novel FOCAD/miR +circulation_biomarker_prognosis_ns 34683154 hsa-mir-625 Mesothelioma, Malignant Serum EV-enriched miR +exosome 34683087 hsa-mir-375 Alzheimer Disease Four common MTI were observed between EV-miRNAs and AD-associated miRNAs: hsa-miR +exosome 34683087 hsa-mir-107 Alzheimer Disease Four common MTI were observed between EV-miRNAs and AD-associated miRNAs: hsa-miR +other 34681793 hsa-mir-205 Breast Neoplasms 3p as down-regulated in BCa compared to normal breast or normal adjacent (NAT) tissues. +other 34681793 hsa-mir-21 Breast Neoplasms 3p as down-regulated in BCa compared to normal breast or normal adjacent (NAT) tissues. +other 34681793 hsa-mir-106b Breast Neoplasms 3p as down-regulated in BCa compared to normal breast or normal adjacent (NAT) tissues. +transcription factor target 34681754 hsa-mir-21 Osteoarthritis Our study demonstrated the role of NFB/miR-21 axis in OA progression, and SC75741's therapeutic potential as a small-molecule inhibitor of miR-21/NFB-driven OA progression. +lncRNA target 34681754 hsa-mir-21 Cartilage Diseases Novel NFB Inhibitor SC75741 Mitigates Chondrocyte Degradation and Prevents Activated Fibroblast Transformation by Modulating miR-21/GDF-5/SOX5 Signaling. +lncRNA target 34681723 hsa-mir-124 Polycystic Kidney Diseases The transcriptional factor of C/EBP-alpha-PU.1 signaling, suppressed by miR-124 both in vivo (PKD retina) and in vitro (microglial cells), could serve as a key regulator in microglial activation and polarization. +transcription factor target 34681681 hsa-mir-143 cervical squamous cell carcinoma Moreover, the miR3p sensitized the response of 7-HPV-related cervical SCC to chemotherapy by targeting BIRC2. +genetics_knock down_suppress 34681655 hsa-mir-542 Osteoporosis Our findings suggest that MTX treatment-induced bone loss and marrow adiposity could be molecularly linked to miR +other 34681596 hsa-mir-17 Familial primary gastric lymphoma 92 cluster miRNAs was significantly reduced in EBV-associated gastric carcinoma (EBVaGC) patients compared with EBV-negative gastric carcinoma (EBVnGC) patients. +other 34681596 hsa-mir-17 hereditary diffuse gastric cancer 92 cluster miRNAs was significantly reduced in EBV-associated gastric carcinoma (EBVaGC) patients compared with EBV-negative gastric carcinoma (EBVnGC) patients. +other 34681596 hsa-mir-17 Epstein-Barr Virus Infections 92 cluster miRNAs was significantly reduced in EBV-associated gastric carcinoma (EBVaGC) patients compared with EBV-negative gastric carcinoma (EBVnGC) patients. +other 34681596 hsa-mir-17 Encephalocraniocutaneous lipomatosis 92 cluster miRNAs was significantly reduced in EBV-associated gastric carcinoma (EBVaGC) patients compared with EBV-negative gastric carcinoma (EBVnGC) patients. +other 34680592 hsa-mir-548a Prostatic Neoplasms Among the 800 profiled microRNA, eleven were identified as correlating with PCa, among which miR-548a-3p, miR5p and miR-520d-3p were confirmed using the RT-qPCR approach on an additional cohort of ten subjects. +other 34680592 hsa-mir-138 Prostatic Neoplasms Among the 800 profiled microRNA, eleven were identified as correlating with PCa, among which miR-548a-3p, miR5p and miR-520d-3p were confirmed using the RT-qPCR approach on an additional cohort of ten subjects. +lncRNA target 34680556 hsa-mir-29b Colorectal Neoplasms In addition, we found that knocking down CRNDE could reduce lipid accumulation through the miR-29b-3p/ANGPTL4 axis and consequently induce autophagy of CRC cells. +circulation_biomarker_diagnosis_ns 34680545 hsa-mir-21 Depressive Disorder, Major In the present study, we isolated serum exosomes from patients with MDD and healthy controls to explore the levels of exosomal microRNAs, including let-7e, miR5p, miR-223, miR-145, miR-146a, and miR-155. +circulation_biomarker_diagnosis_ns 34680545 hsa-let-7e Depressive Disorder, Major In the present study, we isolated serum exosomes from patients with MDD and healthy controls to explore the levels of exosomal microRNAs, including let-7e, miR5p, miR-223, miR-145, miR-146a, and miR-155. +circulation_biomarker_diagnosis_ns 34680545 hsa-mir-145 Depressive Disorder, Major In the present study, we isolated serum exosomes from patients with MDD and healthy controls to explore the levels of exosomal microRNAs, including let-7e, miR5p, miR-223, miR-145, miR-146a, and miR-155. +circulation_biomarker_diagnosis_ns 34680545 hsa-mir-223 Depressive Disorder, Major In the present study, we isolated serum exosomes from patients with MDD and healthy controls to explore the levels of exosomal microRNAs, including let-7e, miR5p, miR-223, miR-145, miR-146a, and miR-155. +circulation_biomarker_diagnosis_ns 34680545 hsa-mir-155 Depressive Disorder, Major In the present study, we isolated serum exosomes from patients with MDD and healthy controls to explore the levels of exosomal microRNAs, including let-7e, miR5p, miR-223, miR-145, miR-146a, and miR-155. +transcription factor target 34680492 hsa-mir-148a Rectal Neoplasms miRNA-148a may be a biomarker of pCR following NACRT and can promote apoptosis and inhibit proliferation in CRC cells by directly targeting c-Met in vitro and enhancing tumor response to irradiation in vivo. +other 34680465 hsa-mir-451 Lung Neoplasms In both LC patient groups, miR-451 expression was downregulated, while those of microRNA-let7c were upregulated, and levels of TEAC and TGF-beta increased compared to the controls. +other 34680465 hsa-mir-451 Pulmonary Disease, Chronic Obstructive In both LC patient groups, miR-451 expression was downregulated, while those of microRNA-let7c were upregulated, and levels of TEAC and TGF-beta increased compared to the controls. +other 34680465 hsa-let-7c Lung Neoplasms In both LC patient groups, miR-451 expression was downregulated, while those of microRNA-let7c were upregulated, and levels of TEAC and TGF-beta increased compared to the controls. +other 34680465 hsa-let-7c Pulmonary Disease, Chronic Obstructive In both LC patient groups, miR-451 expression was downregulated, while those of microRNA-let7c were upregulated, and levels of TEAC and TGF-beta increased compared to the controls. +target gene 34680447 hsa-mir-196a Chondrosarcoma WISP-3 Stimulates VEGF-C-Dependent Lymphangiogenesis in Human Chondrosarcoma Cells by Inhibiting miR-196a-3p Synthesis. +exosome 34680382 hsa-mir-1915 Prostatic Neoplasms Among nine top-ranked sEV-associated miRs, miR-6068 and miR3p were enriched in sEVs collected from PCa patients compared to healthy volunteers. +other 34680382 hsa-mir-6716 Prostatic Neoplasms 3p segregated AA from CA men and low from high Gleason score (GS), respectively. +exosome 34680382 hsa-mir-6068 Prostatic Neoplasms Among nine top-ranked sEV-associated miRs, miR-6068 and miR3p were enriched in sEVs collected from PCa patients compared to healthy volunteers. +other 34680382 hsa-mir-3692 Prostatic Neoplasms 3p segregated AA from CA men and low from high Gleason score (GS), respectively. +circulation_biomarker_diagnosis_ns 34680375 hsa-mir-371a Testicular Germ Cell Tumor We aimed to test the feasibility of hypermethylated RASSF1A (RASSF1A(M)) detected in circulating cell-free DNA as a non-invasive diagnostic marker of testicular germ cell tumors, combined with miR-371a-3p. +genetics_GWAS 34680309 hsa-mir-424 Carcinoma, Renal Cell Altogether, these findings suggest that epigenetic downregulation of miR +other 34678651 hsa-mir-21 Myocardial Infarction, Acute Herein, we rationally developed a metal-organic frameworks-assisted nonenzymatic cascade amplification strategy for simultaneous quantification of three AMI-related miRNAs (miR-21, miR-499 and miR-133a). +other 34678651 hsa-mir-499 Myocardial Infarction, Acute Herein, we rationally developed a metal-organic frameworks-assisted nonenzymatic cascade amplification strategy for simultaneous quantification of three AMI-related miRNAs (miR-21, miR-499 and miR-133a). +other 34678651 hsa-mir-133a Myocardial Infarction, Acute Herein, we rationally developed a metal-organic frameworks-assisted nonenzymatic cascade amplification strategy for simultaneous quantification of three AMI-related miRNAs (miR-21, miR-499 and miR-133a). +exosome 34678513 hsa-mir-34c Renal Interstitial Fibrosis Here, we reveal that mesenchymal stem cell (MSC)-derived exosomes reside specifically in the injured kidney and deliver microRNA (miR)-34c-5p to reduce cellular activation and RIF by inhibiting CF. +circulation_biomarker_diagnosis_up 34678242 hsa-mir-210 Cardiomyopathies The present study was designed to explore whether high sodium chloride (NaCl)-based diet (HSD) caused cardiac fibrosis regardless of blood pressure in Sprague-Dawley (SD) rats, and to further determine the effects and the underlying mechanisms of microRNA (miR) +other 34678217 hsa-mir-16-1 Carcinoma, Hepatocellular MicroRNA-15a/16-1 represents a potential immunotherapy against HCC. +other 34678217 hsa-mir-15a Carcinoma, Hepatocellular MicroRNA-15a/16-1 represents a potential immunotherapy against HCC. +genetics_GWAS 34677712 hsa-mir-372 Hepatitis B In this study, Single nucleotide polymorphisms (SNPs) in miR-372 (rs28461391 C/T) and HULC (rs7763881 A/C) were believed to play a role in HBV infection risk. To the best of our knowledge, the present study was the first to investigate the relevance of miR-372 (rs28461391 C/T) and HULC (rs7763881 A/C) gene polymorphisms to the risk of HBV infection in the Egyptian population. +other 34677646 hsa-mir-629 Anemia, Sickle Cell Our data suggest that low levels of miR510 and miR629 expression are associated with greater SCA disease severity. +other 34677646 hsa-mir-510 Anemia, Sickle Cell Our data suggest that low levels of miR510 and miR629 expression are associated with greater SCA disease severity. +lncRNA target 34676879 hsa-mir-200c Intervertebral Disc Degeneration To construct the IDD cell model, the nucleus pulposus (NP) cells were treated with lipopolysaccharide (LPS) 24 h following transfection with miR200c3p mimic or inhibitor. +other 34676588 hsa-mir-599 Esophageal Squamous Cell Carcinoma The PTPRG-AS1/miR-599/PDK1 axis was further verified to aggravate the progression of ESCC cells. CONCLUSION: PTPRG-AS1 sponged miR-599 to up-regulate PDK1 expression, thereby promoting the proliferation and migration as well as glycolysis and stemness properties of ESCC cells. +exosome 34676493 hsa-mir-27a Osteoporosis This study aimed to evaluate the possible mechanisms of action underlying miR-27a loaded by mesenchymal stem cell (MSC)-derived extracellular vesicles (MSC-EVs) in OP. +circulation_biomarker_diagnosis_ns 34676065 hsa-mir-194 Diabetic Nephropathies We investigated circulating miRNA-194 levels as a biomarker of DKD prevalence and incidence, and the relationship between miRNA-194 and CCAAT/enhancer binding protein (C/EBP) homologous protein (CHOP). Conclusion Circulating miRNA-194 levels could be a novel biomarker for DKD. +other 34676010 hsa-mir-223 Neurodegenerative Diseases Although the function of miR-223 in the inflammation-related JAK/STAT pathway is unknown, it is particularly expressed in human degenerative nucleus pulposus cells. +circRNA target 34675978 hsa-mir-767 Carcinoma, Hepatocellular In summary, this study revealed that circSLC30A7 is an essential tumor suppressor that inhibits HCC tumorigenesis through the miR5p/FBXW7/NOTCH1 axis. +target gene 34675977 hsa-mir-141 Liver Neoplasms miR-141 can target the STAT4 gene expression to inhibit the proliferation, migration, and invasion of liver cancer cells. +transcription factor target 34675825 hsa-mir-181b Autism Spectrum Disorder Conclusions: The dysregulation of hsa-miR-181b-5p, hsa-miR-320a, and hsa-miR-19b-3p could interact with environmental factors, such as maternal stress during pregnancy, neonatal jaundice, and family psychiatric history, to impact the risk of ASD. +transcription factor target 34675825 hsa-mir-19b Autism Spectrum Disorder Conclusions: The dysregulation of hsa-miR-181b-5p, hsa-miR-320a, and hsa-miR-19b-3p could interact with environmental factors, such as maternal stress during pregnancy, neonatal jaundice, and family psychiatric history, to impact the risk of ASD. +transcription factor target 34675825 hsa-mir-20a Autism Spectrum Disorder Conclusions: The dysregulation of hsa-miR-181b-5p, hsa-miR-320a, and hsa-miR-19b-3p could interact with environmental factors, such as maternal stress during pregnancy, neonatal jaundice, and family psychiatric history, to impact the risk of ASD. +lncRNA target 34675680 hsa-mir-542 Carcinoma, Hepatocellular The mechanism, circ-0003006, probably acted as a sponge of miR5423p and regulated HIF-1A levels in hepatocellular carcinoma cells. CONCLUSION: Circ-0003006 was demonstrated to promote HCC progression in vitro and in vivo by sponging miR5423p to release the inhibition on HIF-1A. +other 34675548 hsa-mir-125a Colonic Neoplasms RPARP-AS1/miR125a-5p Axis Promotes Cell Proliferation, Migration and Invasion in Colon Cancer. +transcription factor target 34675545 hsa-mir-489 Squamous Cell Carcinoma of Head and Neck We have identified a novel bypass mechanism through which ET-1/ETAR are involved in TWIST signaling and downregulate miR3p expression, enabling OSCC cells to acquire the EMT phenotype. +circulation_biomarker_diagnosis_up 34675500 hsa-mir-196 Pulmonary Disease, Chronic Obstructive 5p in plasma of COPD patients and healthy volunteers were detected by qRT-PCR. +circulation_biomarker_diagnosis_up 34675500 hsa-mir-361 Pulmonary Disease, Chronic Obstructive 5p in plasma of COPD patients and healthy volunteers were detected by qRT-PCR. +genetics_overexpression_suppress 34674723 hsa-mir-204 Neurotic Disorders In contrast, overexpression of miR +other 34674723 hsa-mir-204 Nerve Degeneration In addition, down-regulation of miR5p induced neuronal deterioration in DG regions and depressive-like behaviors in rats. +other 34674715 hsa-mir-495 Depression 3p, and six differentially expressed mRNAs, Calml4, Ntrk2, VGAT, Gad1, Nr1d1, and Bdnf overlapped in the in vivo/vitro depression model. +other 34674715 hsa-mir-144 Depression 3p, and six differentially expressed mRNAs, Calml4, Ntrk2, VGAT, Gad1, Nr1d1, and Bdnf overlapped in the in vivo/vitro depression model. +lncRNA target 34674104 hsa-mir-490 Periodontal Diseases Thus, the LINC00707/miR3p/FOXO1 axis modulated PDLSC osteogenic differentiation and might be a promising therapeutic target for periodontal diseases. +other 34673407 hsa-mir-155 Chemical and Drug Induced Liver Injury In this study, we investigated the mechanisms by which microRNA-155 (miR-155) regulate cadmium-induced hepatotoxicity in rat hepatocytes (BRL 3A cells) and in vivo. +transcription factor target 34673296 hsa-mir-660 Carcinoma, Hepatocellular 5p-loaded M2-Exo augment HCC development through down-regulating KLF3. +transcription factor target 34672981 hsa-mir-218 Motor Disorders Varying miR-218 dose alters target selection, results in distinct dose-response curves reflecting 3' UTR features, and reveals a miR-218 threshold below which motor neuron deficits emerge. +exosome 34672863 hsa-mir-511 Rhinitis, Allergic In conclusion, our data revealed that exosomal NEAT1 contributed to the pathogenesis of AR through the miR-511/NR4A2 axis. +other 34672722 hsa-mir-149 Hypoxia-Ischemia, Brain It could be concluded that H19 competitively bound to miR5p to upregulate LIF expression and activate the PI3K/Akt pathway, thus reducing cardiomyocyte apoptosis in neonatal rats with HIBD. +other 34672248 hsa-mir-15a Osteoporosis This study provides a modality for the future use of miR-15a-5p in the treatment and prevention of osteoporosis. +exosome 34672203 hsa-mir-78 Ovarian Neoplasms Expression of concern: DDP-resistant ovarian cancer cells-derived exosomal microRNA-30a-5p reduces the resistance of ovarian cancer cells to DDP. +genetics_knock down_promote 34671931 hsa-mir-4319 Colorectal Neoplasms Additionally, HOXA-AS3 knockdown was determined to facilitate miR-4319 expression and reduce expression level of sphingolipid transporter 2 (SPNS2) in CRC cell lines. +other 34671433 hsa-mir-2467 Triple Negative Breast Neoplasms 3p) could be used to discriminate between pCR and non-pCR patients with TNBC with an area under the curve value of 0.7652. +other 34671433 hsa-mir-4448 Triple Negative Breast Neoplasms 3p) could be used to discriminate between pCR and non-pCR patients with TNBC with an area under the curve value of 0.7652. +other 34671433 hsa-mir-2392 Triple Negative Breast Neoplasms 3p) could be used to discriminate between pCR and non-pCR patients with TNBC with an area under the curve value of 0.7652. +lncRNA target 34671432 hsa-mir-193a Adenocarcinoma of Lung Taken together, the results of the present study suggest that SNHG17 expression is upregulated in LUAD tissues and cells, and SNHG17 exerts tumor promoting effect by targeting the miR-193a-5p/NETO2 axis. +target gene 34671430 hsa-mir-125b Breast Neoplasms MicroRNA-100 inhibits breast cancer cell proliferation, invasion and migration by targeting FOXA1. +target gene 34671426 hsa-mir-23b Colorectal Neoplasms MicroRNA-23b-3p targets non-SMC condensing I complex subunit G to promote proliferation and inhibit apoptosis of colorectal cancer cells via regulation of the PI3K/AKT signaling pathway. +exosome 34671216 hsa-mir-150 Fibrosis, Renal Thus, our results suggest that the blockade of exosomal miR +other 34671212 hsa-mir-126 Drug-Induced Kidney Injury In both in vitro and in murine models of DDP-induced nephrotoxicity, lnc-MEG3 exacerbated DDPIN by negatively regulating miRNA-126 subsequently causing a decreased AKT/TSC/mTOR-mediated autophagy. +exosome 34671193 hsa-mir-656 Esophageal Squamous Cell Carcinoma Subsequently, by comparing tumor cell development in vitro and in vivo, we found that the proliferation, migration and invasion capabilities of ESCC cells were significantly improved when miR-3656 was present. Additionally, the downregulation of ACAP2 triggered by exosomal-derived miR-3656 further promotes the activation of the PI3K/AKT and beta-catenin signaling pathways and ultimately improves the growth of ESCC cells both in vitro and in xenograft models. +lncRNA target 34670670 hsa-mir-548at Asthma 5p were important down-regulated molecules, while miR-206, miR-200b-3p, miR-548at-5p, miR-193a-3p and miR-935 were significantly up-regulated miRNAs associated with childhood asthma, and 15 potential target genes such as CCND1, SIRT1 and HDAC4 were the key genes selected. +lncRNA target 34670670 hsa-mir-193a Asthma 5p were important down-regulated molecules, while miR-206, miR-200b-3p, miR-548at-5p, miR-193a-3p and miR-935 were significantly up-regulated miRNAs associated with childhood asthma, and 15 potential target genes such as CCND1, SIRT1 and HDAC4 were the key genes selected. +lncRNA target 34670670 hsa-mir-625 Asthma 5p were important down-regulated molecules, while miR-206, miR-200b-3p, miR-548at-5p, miR-193a-3p and miR-935 were significantly up-regulated miRNAs associated with childhood asthma, and 15 potential target genes such as CCND1, SIRT1 and HDAC4 were the key genes selected. +lncRNA target 34670670 hsa-mir-22 Asthma 5p were important down-regulated molecules, while miR-206, miR-200b-3p, miR-548at-5p, miR-193a-3p and miR-935 were significantly up-regulated miRNAs associated with childhood asthma, and 15 potential target genes such as CCND1, SIRT1 and HDAC4 were the key genes selected. +lncRNA target 34670670 hsa-mir-206 Asthma 5p were important down-regulated molecules, while miR-206, miR-200b-3p, miR-548at-5p, miR-193a-3p and miR-935 were significantly up-regulated miRNAs associated with childhood asthma, and 15 potential target genes such as CCND1, SIRT1 and HDAC4 were the key genes selected. +lncRNA target 34670664 hsa-mir-148b Leukemia, Myeloid, Acute The targeted binding of miR-148b-3p to ATG14 was measured by dual-luciferase reporter gene assay, and the effect of miR-148b-3p/ATG14 axis on the phenotype of AML cells was observed in the rescue experiments. +circRNA target 34670484 hsa-mir-1231 Lichen Planus, Oral The levels of miR-1231, miR-31, miR-647, FOXP3 mRNA and miR-146a were decreased while the expression of TRAF6 mRNA was increased in CD4+ T-cells collected from the EOLP group. And miRNAs including miR-1231, miR-31 and miR-647 were sponged by circ_003912 and down-regulated in CD4+ T cells of the EOLP group, which subsequently up-regulated the expression of FOXP3 and miR-146a, and resulted in the inhibition of NF-kB. +circRNA target 34670484 hsa-mir-146a Lichen Planus, Oral The levels of miR-1231, miR-31, miR-647, FOXP3 mRNA and miR-146a were decreased while the expression of TRAF6 mRNA was increased in CD4+ T-cells collected from the EOLP group. And miRNAs including miR-1231, miR-31 and miR-647 were sponged by circ_003912 and down-regulated in CD4+ T cells of the EOLP group, which subsequently up-regulated the expression of FOXP3 and miR-146a, and resulted in the inhibition of NF-kB. +circRNA target 34670484 hsa-mir-1 Lichen Planus, Oral The levels of miR-1231, miR-31, miR-647, FOXP3 mRNA and miR-146a were decreased while the expression of TRAF6 mRNA was increased in CD4+ T-cells collected from the EOLP group. And miRNAs including miR-1231, miR-31 and miR-647 were sponged by circ_003912 and down-regulated in CD4+ T cells of the EOLP group, which subsequently up-regulated the expression of FOXP3 and miR-146a, and resulted in the inhibition of NF-kB. +circRNA target 34670484 hsa-mir-647 Lichen Planus, Oral The levels of miR-1231, miR-31, miR-647, FOXP3 mRNA and miR-146a were decreased while the expression of TRAF6 mRNA was increased in CD4+ T-cells collected from the EOLP group. And miRNAs including miR-1231, miR-31 and miR-647 were sponged by circ_003912 and down-regulated in CD4+ T cells of the EOLP group, which subsequently up-regulated the expression of FOXP3 and miR-146a, and resulted in the inhibition of NF-kB. +transcription factor target 34670480 hsa-mir-4537 Stomach Neoplasms In conclusion, in GC cells, miR-4537 inhibited the ability of cell proliferation, but on the contrary, it promoted the ability of cell apoptosis and improved radiosensitivity of the cells. +other 34670429 hsa-mir-22 Neurotoxicity Syndromes CONCLUSION: LXA(4) ME can protect PC12 cells from ketamine-induced neurotoxicity by activating the miR-22/BAG5 signaling pathway. +lncRNA target 34669172 hsa-mir-145 Osteoarthritis 5p was up-regulated, and the expression of TGF-beta, Samd4, and p-stat3/stat3 was inhibited. +lncRNA target 34669152 hsa-mir-4691 COVID-19 5p, showed preferential targeting of the SARS-CoV-2 genome over the cell's Diabetes-associated messenger RNAs (mRNAs) in the human pancreas. +lncRNA target 34669152 hsa-mir-3925 COVID-19 5p, showed preferential targeting of the SARS-CoV-2 genome over the cell's Diabetes-associated messenger RNAs (mRNAs) in the human pancreas. +lncRNA target 34669152 hsa-mir-5196 COVID-19 5p, showed preferential targeting of the SARS-CoV-2 genome over the cell's Diabetes-associated messenger RNAs (mRNAs) in the human pancreas. +lncRNA target 34669152 hsa-mir-298 COVID-19 5p, showed preferential targeting of the SARS-CoV-2 genome over the cell's Diabetes-associated messenger RNAs (mRNAs) in the human pancreas. +transcription factor target 34668631 hsa-mir-99a Lupus Erythematosus, Systemic The upregulation of miR-99a-3p expression protected B cells from EIF4EBP1-mediated autophagy, whilst the downregulation of miR-99a-3p expression induced autophagy via the EIF4EBP1-mediated regulation of the autophagy signalling pathway in B cells isolated from individuals with SLE. +other 34668628 hsa-mir-1228 Breast Neoplasms positive BC. +genetics_overexpression_promote 34668437 hsa-mir-223 Pulmonary Disease, Chronic Obstructive Finally, in vitro overexpression of miR +genetics_overexpression_promote 34668437 hsa-mir-223 Pneumonia Finally, in vitro overexpression of miR +other 34668391 hsa-mir-24 Alzheimer Disease 3p has a certain value in the diagnosis of AD and may be a potential biomarker. +other 34668337 hsa-mir-155 Breast Neoplasms miRNA (miR)-155 is a potential biomarker for breast cancers. +genetics_overexpression_promote 34668273 hsa-mir-129 Intervertebral Disc Degeneration 5p was underexpressed, and EZH2 and MAPK1 levels were overexpressed in lumbar nucleus pulposus from human IVDD patients and in LPS-induced NP cells. +lncRNA target 34668101 hsa-mir-377 Lung Neoplasms CONCLUSIONS: All these data reveal that miRNA-377 functions as a tumor suppressor in NSCLC and may serve as a potential therapeutic target for the treatment of NSCLC. +exosome 34667723 hsa-mir-29b Diabetes Mellitus Exosomal miRNA sequencing revealed that miR-29b was significantly downregulated in DMC group compared with ARC. +exosome 34667723 hsa-mir-29b Cataract Exosomal miRNA sequencing revealed that miR-29b was significantly downregulated in DMC group compared with ARC. +other 34667438 hsa-mir-224 Colorectal Neoplasms The main objective of this study was to determine the role of microRNA-224 (miR-224) as well as microRNA-200a (miR-200a) in CRC. +other 34667438 hsa-mir-200a Colorectal Neoplasms The main objective of this study was to determine the role of microRNA-224 (miR-224) as well as microRNA-200a (miR-200a) in CRC. +epigenetics 34667160 hsa-mir-135a Colorectal Neoplasms More importantly, we found that miR-135a-5p expression is reversely upregulated by ERp29 through suppressing IL-1beta-elicited methylation of miR-135a-5p promoter region, a process for enterocyte to maintain a balance between miR-135a-5p and ERp29 but dysregulated in CRC. +other 34667156 hsa-mir-4523 Necrosis Significantly, miR-4523 is downregulated in human necrotic femoral head tissues of DEX-taking patients. +genetics_knock down_suppress 34666672 hsa-mir-124 Inflammation Knockdown of MAPKAPK5-AS1 reduced LPS-induced cell apoptosis and inflammation response, while overexpression of miR +lncRNA target 34666613 hsa-mir-522 Carcinoma, Hepatocellular 3p/SOCS5 axis as a novel target for HCC therapeutic strategy with potentiality. +lncRNA target 34666602 hsa-mir-20a Esophageal Squamous Cell Carcinoma Overall, METTL3 promoted m6A modification and the binding of DGCR8 to miR-20a-5p to further elevate the miR-20a-5p expression and inhibit NFIC transcription, thus promoting EMT, invasion and migration. +other 34666057 hsa-mir-503 Pulmonary Fibrosis Our data indicated that PRSS8, hsa-miR-614, and hsa-miR5p might be involved in the migration and invasion of IPF related cells. +other 34666057 hsa-mir-614 Pulmonary Fibrosis Our data indicated that PRSS8, hsa-miR-614, and hsa-miR5p might be involved in the migration and invasion of IPF related cells. +genetics_GWAS 34665919 hsa-mir-376 Glioma Herein, we describe the epigenetic silencing of the uc.160+ T-UCR in gliomas and mechanistically define a novel RNA-RNA regulatory network in which uc.160+ modulates the biogenesis of several members of the miR-376 cluster. +circulation_biomarker_diagnosis_up 34665700 hsa-mir-183 Behcet Syndrome 5p derived from plasma exosomes may serve as biomarkers of disease activity in intestinal BS. +circulation_biomarker_diagnosis_up 34665700 hsa-mir-150 Behcet Syndrome 5p derived from plasma exosomes may serve as biomarkers of disease activity in intestinal BS. +circulation_biomarker_diagnosis_up 34665700 hsa-mir-141 Behcet Syndrome 5p derived from plasma exosomes may serve as biomarkers of disease activity in intestinal BS. +circulation_biomarker_diagnosis_up 34665700 hsa-mir-342 Behcet Syndrome 5p derived from plasma exosomes may serve as biomarkers of disease activity in intestinal BS. +circulation_biomarker_diagnosis_up 34665700 hsa-mir-224 Behcet Syndrome 5p derived from plasma exosomes may serve as biomarkers of disease activity in intestinal BS. +circulation_biomarker_diagnosis_up 34665700 hsa-mir-122 Behcet Syndrome 5p derived from plasma exosomes may serve as biomarkers of disease activity in intestinal BS. +genetics_overexpression_promote 34665305 hsa-mir-34a Carcinoma, Hepatocellular In HCC cells, TLR8-AS1 overexpression downregulated mature miR-34a, but not miR-34a precursor. +genetics_knock down_promote 34664835 hsa-mir-125a Cholesteatoma Also, circ_0074491 knockdown activated the PI3K/Akt pathway in cholesteatoma keratinocytes via miR +lncRNA target 34664776 hsa-mir-625 Carcinoma, Non-Small-Cell Lung Notably, circ-SNAP47 interference suppressed xenograft tumor growth of DDP-tolerant NSCLC cells by elevating miR +genetics_overexpression_promote 34664737 hsa-mir-125b Carcinoma, Hepatocellular In addition, the inhibition of miR-125b and HK2 overexpression partly reversed the inhibitory effect of hsa_circ_0001806 silencing on HCC cell proliferation, migration and glycolysis. CONCLUSION: The inhibition of hsa_circ_0001806 suppressed HCC cell proliferation, migration and glycolysis through mediating miR-125b/HK2 axis. +other 34664684 hsa-mir-17 Coronary Disease The results suggested that hsa_circ_105039 exerted a protective effect by promoting miR17/cyclinD2 in DMSOinduced iPS cardiomyocytes, which indicated that hsa_circ_105039 is a potential key molecule for the diagnosis of CHD. +other 34664683 hsa-mir-491 Pulmonary Disease, Chronic Obstructive Reverse transcriptionquantitative PCR was carried out to evaluate the expression of miR491 and MMP9 mRNA in the different groups of patients with COPD. Although there was no difference in the expression of miR491 in patients carrying different genotypes of rs1056629, the expression levels of TNFalpha, IL6 and MMP9 were increased in patients with COPD carrying the CC and AC genotypes of rs1056629. +genetics_overexpression_promote 34664678 hsa-mir-497 Glioma In addition, forced overexpression of miR497 or MIR497HG significantly inhibited the proliferation and cell cycle progression of glioma cell lines. +lncRNA target 34664412 hsa-mir-494 Reperfusion Injury, Hepatic Ischemia Functional rescue experiments were performed to confirm the effects of miR-494 and JUND on hepatic I/R injury. Overall, Dex repressed NLRP3 inflammasome and alleviated hepatic I/R injury via the miR-494/JUND/PI3K/AKT/Nrf2 axis. +other 34663892 hsa-mir-582 Obesity These whole-body and cellular phenotypes were associated with age-dependent changes in expression of miRNA-582 that might contribute mechanistically to the development of metabolic disorders in the older progeny. +other 34663892 hsa-mir-582 Metabolic Diseases These whole-body and cellular phenotypes were associated with age-dependent changes in expression of miRNA-582 that might contribute mechanistically to the development of metabolic disorders in the older progeny. +lncRNA target 34663837 hsa-mir-186 Squamous Cell Carcinoma of Head and Neck MiR-186 was reported to serve as a tumor suppressor in OSCC, and the down-regulation of miR-186 was reported to lead to higher expression of oncogenic factor SHP2 and the activation of growth promoting signaling. +other 34663837 hsa-mir-296 Squamous Cell Carcinoma of Head and Neck 5p was specifically up-regulated in saliva of OSCC patients. +other 34663368 hsa-mir-4303 Osteoarthritis In this paper, we aim to investigate the underlying mechanisms by which miR-4303 regulates osteoarthritis. +exosome 34663350 hsa-mir-769 Osteosarcoma CONCLUSIONS: In summary, this study demonstrates for the first time that BMSC-derived exosomal miR +lncRNA target 34663343 hsa-mir-1285 Adenocarcinoma of Lung CONCLUSIONS: These results suggest that LINC00337 acts as an oncogenic lncRNA, targeting miR3p and regulating YTHDF1 expression, to promote the progression of lung adenocarcinoma. +target gene 34663310 hsa-mir-152 Breast Neoplasms TBX15/miR-152/KIF2C pathway regulates breast cancer doxorubicin resistance via promoting PKM2 ubiquitination. +transcription factor target 34663177 hsa-mir-744 Cardiomyopathies CONCLUSION: Our findings provide new insights that ISO pretreatment can remarkedly regulate miR-744 and its downstream target SIRT6 to mitigate myocardial injury induced by H/R. +lncRNA target 34663169 hsa-mir-23b Spinal Cord Injuries After EV treatment, the motor function of SCI rats was improved, SCI was relieved, and miR-23b expression was increased. To conclude, The miR-23b delivered by BMSC-EVs targets TLR4 and inhibits the activation of NF-kappaB pathway, relieves the inflammatory response, so as to improve SCI in rats. +other 34661851 hsa-mir-7a Ischemia MicroRNA-7a-5p (miR-7a-5p) is closely related to apoptosis and plays an important role in ischemia/reperfusion (I/R) injury. +other 34661851 hsa-mir-7a Myocardial Reperfusion Injury MiR-7a-5p/VDAC1 axis might be utilized as hopeful biomarkers to reveal the potential mechanism of myocardial I/R injury. +lncRNA target 34661812 hsa-mir-134 Ischemic Stroke Ectopic SNHG7 expression protected against OGD-induced neuronal cell injury by inducing FGF9 through sponging miR5p, providing a novel therapeutic target for ischemic stroke. +lncRNA target 34661812 hsa-mir-134 Osteochondritis Dissecans Ectopic SNHG7 expression protected against OGD-induced neuronal cell injury by inducing FGF9 through sponging miR +circulation_biomarker_diagnosis_ns 34661810 hsa-mir-1260a Breast Neoplasms miR-4521 and miR-1260a showed no change in plasma of breast cancer patients (n = 19). +other 34661810 hsa-mir-93 Breast Neoplasms 5p. +other 34661810 hsa-mir-16 Breast Neoplasms 5p. +circulation_biomarker_diagnosis_ns 34661810 hsa-mir-4521 Breast Neoplasms miR-4521 and miR-1260a showed no change in plasma of breast cancer patients (n = 19). +other 34661762 hsa-mir-34 Non-alcoholic Fatty Liver Disease The AUCs (CI) of candidate NAFLD markers were in the order of miRNA-34 0.72 (0.66-0.77) < ALT 0.73 (0.67-0.79) < BMI 0.81 (0.76-0.86) < cholesterol < 0.85 (0.79-0.90) < CRP 0.88 (0.84-0.92). +other 34661743 hsa-mir-129 Brain Ischemia Transient cerebral ischemia induces differential expression of miR-129 and miR-384-5p which influences apoptosis by regulating apoptotic factors caspase-3 and bcl-2 +other 34661743 hsa-mir-384 Brain Ischemia Transient cerebral ischemia induces differential expression of miR-129 and miR-384-5p which influences apoptosis by regulating apoptotic factors caspase-3 and bcl-2 +other 34661273 hsa-mir-370 Colorectal Neoplasms 5p/EZH1 axis. +circulation_biomarker_diagnosis_ns 34661272 hsa-mir-200b Lung Neoplasms CONCLUSIONS: Low-dose spiral CT combined with plasma miR-200b and miR-200c for lung cancer screening in the physical examination population can help to detect lung cancer patients with early symptoms that are not significant, and achieve early diagnosis and early treatment. +circulation_biomarker_diagnosis_ns 34661272 hsa-mir-200c Lung Neoplasms CONCLUSIONS: Low-dose spiral CT combined with plasma miR-200b and miR-200c for lung cancer screening in the physical examination population can help to detect lung cancer patients with early symptoms that are not significant, and achieve early diagnosis and early treatment. +lncRNA target 34660700 hsa-mir-138 Hemangioma, Infantile Taken together, we demonstrate that LncRNA-MCM3AP-AS1 promotes the progression of infantile hemangiomas by increasing the glycolysis via regulating miR5p/HIF-1alpha axis. +other 34660700 hsa-mir-106b Hemangioma, Infantile Furthermore, we demonstrated that MCM3AP-AS1 bound to miR-106b-3p which promotes glycolysis in IH. +circulation_biomarker_diagnosis_ns 34660637 hsa-mir-19b-1 Urothelial Carcinoma In plasma samples, miR +circulation_biomarker_diagnosis_ns 34660637 hsa-mir-378 Urothelial Carcinoma In plasma samples, miR +other 34660637 hsa-mir-19a Urothelial Carcinoma The Kaplan-Meier curve showed that lower expression of miR-19a, miR-19b, miR-636 and miR-378, and higher expression of miR5p were associated with poor prognosis in patients with bladder cancer. +circulation_biomarker_diagnosis_ns 34660637 hsa-mir-155 Urothelial Carcinoma In plasma samples, miR +circulation_biomarker_diagnosis_ns 34660637 hsa-mir-636 Urothelial Carcinoma In plasma samples, miR +other 34660637 hsa-mir-708 Urothelial Carcinoma The Kaplan-Meier curve showed that lower expression of miR-19a, miR-19b, miR-636 and miR-378, and higher expression of miR5p were associated with poor prognosis in patients with bladder cancer. +circulation_biomarker_diagnosis_ns 34660637 hsa-mir-19b Urothelial Carcinoma In plasma samples, miR +other 34660566 hsa-mir-129 Pancreatic Neoplasms Pancreatic Cancer Progression Is Regulated by IPO7/p53/LncRNA MALAT1/MiR-129-5p Positive Feedback Loop. +target gene 34660323 hsa-mir-375 Stomach Neoplasms Long Non-Coding RNA GRIK1-AS1 Inhibits the Proliferation and Invasion of Gastric Cancer Cells by Regulating the miR-375/IFIT2 Axis. +genetics_overexpression_promote 34660270 hsa-mir-148a Carcinoma, Hepatocellular MiR-148a-3p overexpression effectively inhibited HCC cell proliferation and metastasis stimulated by MTF-1, with increased apoptosis. +exosome 34660257 hsa-mir-532 Osteosarcoma CircNRIP1 Encapsulated by Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicles Aggravates Osteosarcoma by Modulating the miR-532-3p/AKT3/PI3K/AKT Axis. +other 34659890 hsa-mir-27a Carcinoma, Non-Small-Cell Lung Downregulation of HOXC6 by miR-27a ameliorates gefitinib resistance in non-small cell lung cancer. +transcription factor target 34659819 hsa-mir-488 Esophageal Squamous Cell Carcinoma 5p targets associated with ESCC. +circulation_biomarker_diagnosis_up 34659807 hsa-mir-10a Pneumonia, Mycoplasma Among paediatric MPP patients, miR-10a-3p expression had a positive correlation with the white blood cells count, erythrocyte sedimentation rate (ESR), and CRP expression, while COX11 mRNA expression had a positive correlation with ESR and CRP. +genetics_GWAS 34659590 hsa-mir-149 Autoimmune Diseases In addition, associations were observed between miR-149 rs2292832/miR-27a rs895819 and AD susceptibility in the overall population (allele model, OR = 1.15, 95% CI: 1.06-1.24, P < 0.001; allele model, OR = 1.11, 95% CI:1.01-1.22, P = 0.043, respectively). CONCLUSIONS: Evidence from our systematic review suggests that miR-146a, miR-196a2, miR-499, miR-149, and miR-27a polymorphisms are associated with susceptibility to AD. +genetics_GWAS 34659590 hsa-mir-27a Autoimmune Diseases In addition, associations were observed between miR-149 rs2292832/miR-27a rs895819 and AD susceptibility in the overall population (allele model, OR = 1.15, 95% CI: 1.06-1.24, P < 0.001; allele model, OR = 1.11, 95% CI:1.01-1.22, P = 0.043, respectively). CONCLUSIONS: Evidence from our systematic review suggests that miR-146a, miR-196a2, miR-499, miR-149, and miR-27a polymorphisms are associated with susceptibility to AD. +other 34659578 hsa-mir-29a Carcinoma, Hepatocellular TUG1 promotes the expression of IFITM3 in hepatocellular carcinoma by competitively binding to miR-29a. +target gene 34659572 hsa-mir-206 Ovarian Neoplasms Keratin 80 regulated by miR-206/ETS1 promotes tumor progression via the MEK/ERK pathway in ovarian cancer. +genetics_overexpression_promote 34659565 hsa-mir-338 Stomach Neoplasms 5p was significantly lower-expression in cisplin-resistant GC cells SGC7901/DDP, and cell viability assay and flow cytometry confirmed that overexpression of miR +other 34659561 hsa-mir-182 Breast Neoplasms miR-182 is upregulated in breast, lung and liver cancers and has good potential for cancer diagnosis. +other 34659561 hsa-mir-182 Carcinoma, Hepatocellular miR-182 is upregulated in breast, lung and liver cancers and has good potential for cancer diagnosis. +transcription factor target 34659560 hsa-mir-25 Urinary Bladder Neoplasms BC cell lines T24 and 5637 were used to transfect miR-25 mimics or inhibitors. +genetics_knock down_promote 34659556 hsa-mir-143 Stomach Neoplasms The knockdown of hsa_circRNA_101996 dramatically suppressed the cell migration, invasion, and proliferation of GC cells by sponging to absorb miR-143 and elevated the expression of TET2. +target gene 34659550 hsa-mir-4507 Carcinoma, Non-Small-Cell Lung MIR-4507 Targets TP53 to Facilitate the Malignant Progression of Non-small-cell Lung Cancer. +genetics_knock down_suppress 34659544 hsa-mir-527 Carcinoma, Hepatocellular Knockdown of hsa_circ_0001306 could downregulate F-box and WD repeat domain containing 7(FBXW7), a target of miR-527, thereby promoting HCC cell proliferation and invasion. Hsa_circ_001306 is significantly downregulated in HCC, and the hsa_circ_0001306/miR-527/FBXW7 axis plays an important role in HCC progression. +lncRNA target 34659543 hsa-mir-28 Squamous Cell Carcinoma of Head and Neck 3p directly targeted the 3'UTR of H2A histone family, member X (H2AFX), which served as a tumor suppressor in migration and invasion of HNSCC. +genetics_knock down_promote 34659534 hsa-mir-29c Pancreatic Carcinoma HOXA-AS3 level was upregulated in PC, and its knockdown suppressed PC cells proliferation, whereas miR-29c antagonized the regulatory effect of HOXA-AS3 knockdown by directly binding to HOXA-AS3.Moreover, CDK6 was a target of miR-29c and miR-29c exerted anti-proliferation effects through inhibiting CDK6. +lncRNA target 34659523 hsa-mir-185 Pancreatic Carcinoma Lastly, LINC00152 inhibition targeted miR +target gene 34659511 hsa-mir-361 Pancreatic Neoplasms MicroRNA-361 reduces the viability and migratory ability of pancreatic cancer cells via mediation of the MAPK/JNK pathway. +lncRNA target 34659510 hsa-mir-1236 Glioblastoma The results demonstrated that LGR6, a microRNA3p target candidate, promoted GBM cell viability and invasion, and mediated temozolomide sensitivity in SHG-44 and U251 GBM cells. +other 34659508 hsa-mir-145 Cardiomegaly 5p may indicate the severity of CHF, may serve as diagnostic and prognostic biomarkers and may be involved in CHF progression by regulating inflammatory responses. +lncRNA target 34659498 hsa-mir-218 Spinal Cord Injuries Depletion of miR-218 protected PC12 cells against H(2)O(2)-induced cell injury via the upregulation of spred2, which provided a promising therapeutic strategy for spinal cord injury. +other 34659494 hsa-mir-142 Liver Neoplasms lncRNA ST8SIA6-AS1 facilitates proliferation and invasion in liver cancer by regulating miR-142-3p. +other 34659430 hsa-mir-5007 Carcinoma, Hepatocellular LncRNA-URHC Functions as ceRNA to Regulate DNAJB9 Expression by Competitively Binding to miR-5007-3p in Hepatocellular Carcinoma. +other 34659414 hsa-mir-495 Breast Neoplasms The study concluded that the decreased expression of miR-495 observed in breast cancer patients showed a negative correlation with NRXN-1 while the increased expression of NRXN-1 and CNTN-1 was linked with disease advancement and distant metastases and could be the important predictive marker for breast cancer patients. +transcription factor target 34659411 hsa-mir-520b Breast Neoplasms CONCLUSIONS: miR-520b inhibited PTEN and aggravated breast tumors. +transcription factor target 34659401 hsa-mir-141 Polycystic Ovary Syndrome 3p might play a role in glucose and lipid metabolism in PCOS-obese patients by targeting PTEN. +genetics_overexpression_promote 34659347 hsa-mir-423 Hepatoblastoma Furthermore, through conducting reversal experiments, we evidenced that the inhibiting effects of circSETD3 overexpression on HB development were abrogated by upregulating miR +other 34659329 hsa-mir-873 Stomach Neoplasms CircC6orf132 Facilitates Proliferation, Migration, Invasion, and Glycolysis of Gastric Cancer Cells Under Hypoxia by Acting on the miR-873-5p/PRKAA1 Axis. +lncRNA target 34658906 hsa-mir-195 Cardiomyopathies 5p inhibits TGF-beta1-smads-snail pathway by targeting Smad7, thus inhibiting EndMT and alleviating myocardial fibrosis in DCM. +lncRNA target 34658906 hsa-mir-195 Diabetic Cardiomyopathies 5p inhibits TGF-beta1-smads-snail pathway by targeting Smad7, thus inhibiting EndMT and alleviating myocardial fibrosis in DCM. +circulation_biomarker_diagnosis_ns 34658571 hsa-mir-21 Esophageal Neoplasms This study aimed to isolate MiR 21 from serum samples of carcinoma oesophagus patients and healthy subjects for determining its strength of association in various stages of the carcinoma oesophagus. +lncRNA target 34658308 hsa-mir-101 Burkitt Lymphoma In conclusion, TCF3 combined with HDAC3 down-regulates the expression of miR-101, thereby promoting the proliferation of BL cells and inhibiting their apoptosis. +lncRNA target 34658294 hsa-mir-150 Pancreatic Carcinoma Together, these findings indicate that a noval m6A-LIFR-AS1 axis promotes PC progression at least in part via regulation of the miR5p/VEGFA axis, indicating that this regulatory axis may be a viable clinical target for the treatment of PC. +genetics_knock down_promote 34658165 hsa-mir-646 Carcinoma, Non-Small-Cell Lung MiR-646 bound to the AKT3 3' untranslated region in NSCLC cells, and miR-646 overexpression-induced effects in NSCLC cells were partly overturned by the addition of AKT3 overexpression plasmid. +genetics_overexpression_promote 34658120 hsa-mir-338 Stomach Neoplasms 3p in HAGLR-overexpressing HGC27 5-Fu R cells successfully overrode the HAGLR-promoted 5-Fu resistance through targeting LDHA. +transcription factor target 34657879 hsa-mir-129 gastric adenocarcinoma Furthermore, key targets related to TLR3 were identified in STAD, mainly including MIR-129 (GCAAAAA), PLK1, and V$IRF1_01. +genetics_overexpression_suppress 34657624 hsa-mir-144 Stomach Neoplasms 3p overexpression inhibited proliferation, migration and invasion of gastric cancer cells. +lncRNA target 34657558 hsa-mir-340 Breast Neoplasms All in all, LINC01094 promotes BC cell proliferation and cell cycle progression and inhibits apoptosis via modulating miR +genetics_overexpression_suppress 34657551 hsa-mir-130a Colorectal Neoplasms MiR-130a-3p overexpression contributed to a decrease in CRC cell proliferation. +other 34657331 hsa-mir-196b Asthenozoospermia 3p and miR-196b-5p) were identified in asthenospermia for the first time in this study. +other 34657331 hsa-mir-449a Asthenozoospermia 3p and miR-196b-5p) were identified in asthenospermia for the first time in this study. +other 34657331 hsa-mir-135a Asthenozoospermia 3p and miR-196b-5p) were identified in asthenospermia for the first time in this study. +other 34657331 hsa-mir-146b Asthenozoospermia 3p and miR-196b-5p) were identified in asthenospermia for the first time in this study. +other 34657331 hsa-mir-34c Asthenozoospermia 3p and miR-196b-5p) were identified in asthenospermia for the first time in this study. +other 34657331 hsa-mir-6739 Asthenozoospermia 3p and miR-196b-5p) were identified in asthenospermia for the first time in this study. +other 34657331 hsa-mir-34b Asthenozoospermia 3p and miR-196b-5p) were identified in asthenospermia for the first time in this study. +other 34657331 hsa-mir-765 Asthenozoospermia 3p and miR-196b-5p) were identified in asthenospermia for the first time in this study. +other 34657331 hsa-mir-5000 Asthenozoospermia 3p and miR-196b-5p) were identified in asthenospermia for the first time in this study. +other 34657232 hsa-mir-29b Glaucoma Our study is the first experimental investigation to shed light on a novel molecular mechanism of the GAS5/miR-29b-3p/STAT3 axis in an H(2)O(2)-induced oxidative injury model using HTMCs, which may offer a promising therapeutic approach against glaucoma. +circRNA target 34657099 hsa-mir-548p Carcinoma, Hepatocellular Circ_0073181 and PTPRE were upregulated, and miR-548p was decreased in HCC tissues and cells. Circ_0073181 silencing could inhibit HCC cell growth and metastasis partly by regulating the miR-548p/ PTPRE axis, providing a promising therapeutic target for the HCC treatment. +lncRNA target 34656159 hsa-mir-1265 Colorectal Neoplasms CONCLUSION: Our results identified that circSLC6A6/miR-1265/C2CD4A axis, which was involved in CRC via the p53 signaling pathway, may serve as a therapeutic target for CRC. +genetics_knock down_promote 34656128 hsa-mir-3065 Colorectal Neoplasms 3p was overexpressed in colorectal cancer and that its high expression was associated with poor prognosis of patients with colorectal cancer. +genetics_overexpression_suppress 34656115 hsa-mir-140 Stomach Neoplasms Overexpression of SNHG12 or FAM83B reduced the inhibition of overexpression of miR +genetics_GWAS 34656082 hsa-mir-146a Brucellosis The aim of the present study was to investigate the association between risk of brucellosis and genetic variations in miR-146a. CONCLUSIONS: Consequently, our study demonstrated significant differences in genotype and haplotype frequencies of miR-146a variants between brucellosis patients and controls. +genetics_overexpression_promote 34656078 hsa-mir-23b Leukemia, Myeloid, Acute The expression of miR-23b-5p and TRIM14 was silenced or overexpressed to explore their biological functions in AML. +lncRNA target 34656066 hsa-mir-135b Atrial Fibrillation RESULTS: The expression of miR-135b was downregulated, and those of TGFBR1, TGFBR2, target genes of miR-135b were upregulated in human AF tissues and negatively regulated by miR-135b in RCFs. CONCLUSION: Quercetin may alleviate AF by inhibiting fibrosis of atrial tissues through inhibiting TGF-beta/Smads pathway via promoting miR-135b expression. +lncRNA target 34655977 hsa-mir-148b Keloid These results find that HOXA11-AS promotes keloid progression by miR-148b-3p/IGFBP5 axis, suggesting the potential of targeting HOXA11-AS/miR-148b-3p/IGFBP5 axis to combat keloid. +lncRNA target 34655847 hsa-mir-18b Diabetic Retinopathy In addition, miR-18b was found to target mitogen-activated protein kinase kinase kinase 1 (MAP3K1), thereby inhibiting NF-kappaB p65 phosphorylation to alleviate DR. Overall, this study highlights the potential of hUCMSCs-sEVs as biomaterials for anti-inflammatory and anti-apoptotic effects in DR by transferring miR-18b. +lncRNA target 34655744 hsa-let-7d Polycystic Ovary Syndrome In conclusion, miR-let-7d-3p was a crucial miRNA up-regulated in GCs of PCOS, and inhibited cell proliferation by targeting TLR4 gene. +other 34655407 hsa-mir-522 Breast Neoplasms 3p to PBX1 3'-UTR and may be suggested as a novel prognostic biomarker for the diseases. +transcription factor target 34655390 hsa-mir-409 Stroke Collectively, rTMS could protect against stroke-induced cognitive deficits, which depended on the inhibition of miR +genetics_overexpression_promote 34655362 hsa-mir-574 Stomach Neoplasms 3p was overexpressed in GC tissues and cells. +exosome 34655361 hsa-mir-192 Gallbladder Neoplasms 5p/MAD2L1 axis was identified, suggesting lncRNA STEAP3-AS1, might as a sponge of exosome-derived hsa-miR +other 34655330 hsa-mir-34a Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Then the synergic effects of miR-34a in combination with doxorubicin were investigated on cell death of acute T-cell lymphoblastic leukemia Jurkat cell line, as well as the expression of some genes including Caspase-3, Bcl-2, and p53 which are involved in apoptosis. +other 34655124 hsa-mir-96 Prostatic Neoplasms 5p mimic presented a cancer promoter role in prostate carcinoma cells. +circulation_biomarker_diagnosis_ns 34654834 hsa-mir-532 Lung Neoplasms 5p was quantifiable in plasma from the corresponding LUADs. +transcription factor target 34654817 hsa-mir-150 Brain Injuries We show that miR-328a-3p and miR5p, enriched in the sEVs after TBI, promote osteogenesis by directly targeting the 3'UTR of FOXO4 or CBL, respectively, and hydrogel carrying miR-328a-3p-containing sEVs efficiently repaires bone defects in rats. +transcription factor target 34654817 hsa-mir-328a Bone Diseases We show that miR-328a-3p and miR5p, enriched in the sEVs after TBI, promote osteogenesis by directly targeting the 3'UTR of FOXO4 or CBL, respectively, and hydrogel carrying miR-328a-3p-containing sEVs efficiently repaires bone defects in rats. +transcription factor target 34654817 hsa-mir-150 Bone Diseases We show that miR-328a-3p and miR5p, enriched in the sEVs after TBI, promote osteogenesis by directly targeting the 3'UTR of FOXO4 or CBL, respectively, and hydrogel carrying miR-328a-3p-containing sEVs efficiently repaires bone defects in rats. +transcription factor target 34654817 hsa-mir-328a Brain Injuries We show that miR-328a-3p and miR5p, enriched in the sEVs after TBI, promote osteogenesis by directly targeting the 3'UTR of FOXO4 or CBL, respectively, and hydrogel carrying miR-328a-3p-containing sEVs efficiently repaires bone defects in rats. +other 34654721 hsa-mir-19b Glioblastoma Finally, we find that by a Cx43-dependent mechanism, but likely not direct channel-mediated diffusion, miRNAs associated with cell-matrix adhesion are transferred from GBM to astrocytes and miR-19b promotes invasion, revealing a role for post-transcriptional manipulation of astrocytes in fostering an invasion-permissive peritumoral niche. +genetics_knock down_promote 34654473 hsa-mir-93 Diabetic Nephropathies CONCLUSION: KCNQ1OT1 knockdown inhibited cell proliferation and fibrosis and induced apoptosis in DN by regulating miR +circulation_biomarker_prognosis_ns 34654440 hsa-mir-499a Myocardial Dysfunction RESULTS: Our results revealed a poor expression of miR-499a-5p in the serum of SIMD patients, while no significant difference was evident for miR-451 and miR-378. +circulation_biomarker_prognosis_ns 34654440 hsa-mir-499a Sepsis RESULTS: Our results revealed a poor expression of miR-499a-5p in the serum of SIMD patients, while no significant difference was evident for miR-451 and miR-378. +other 34654438 hsa-mir-132 Alzheimer Disease glutamate and GABA oppositely regulated miR-132 levels in sEVs, resulting in the opposite destiny of recipient cells challenged with Aβ. +lncRNA target 34654357 hsa-mir-143 Abortion, Spontaneous 3p/S100A11 axis, providing novel biomarkers and diagnostic targets for RPL. +genetics_GWAS 34654353 hsa-mir-877 Prostatic Neoplasms 5p action on prostate cancer cells was investigated by luciferase activity assay with wide-type or mutation. +exosome 34653794 hsa-mir-142 Lung Neoplasms CAFs-derived exosomes suppressed the role of PBMCs induced-killing of lung cancer cells and promoted lung cancer progression by OIP5-AS1/ miR +other 34653751 hsa-mir-449 Papilloma, Inverted Notably, the miR-449 cluster was found to be significantly underexpressed in SNSCC, and the cluster markedly changed in SNIP during the malignant transition into SNSCC. CONCLUSIONS: Our findings suggest that miR-449 may be involved in the molecular pathogenesis of SNIP and its malignant transformation into SNSCC. +other 34653729 hsa-mir-93 Severe Acute Respiratory Syndrome The results obtained demonstrate that the production of IL-8 protein is enhanced in bronchial epithelial IB3-1 cells by treatment with the SARS-CoV-2 Spike protein and that IL-8 synthesis and extracellular release can be strongly reduced using an agomiR molecule mimicking miR5p. +lncRNA target 34653678 hsa-mir-6512 Periodontitis In conclusions, SNHG7 improves the osteogenic differentiation of hDPSCs by inhibiting miR3p expression under 50 ng/mL TNF-alpha-induced inflammatory environment, which provided potential targets for the treatment of periodontitis. +other 34652942 hsa-mir-1 Muscular Diseases We uncovered a muscle cell vulnerability by studying miR-1, a deeply conserved, muscle-specific microRNA whose ablation causes various muscle defects. +genetics_knock down_promote 34652879 hsa-mir-708 Uterine Cervical Neoplasms 5p inhibitor attenuated the effects of LINC00514 knockdown on cell proliferation and invasion in CSCC cells. +other 34652691 hsa-mir-494 Neurotoxicity Syndromes 3p upregulation in primary cultured hippocampal neurons. +lncRNA target 34652636 hsa-mir-124 Neurogenic Inflammation MiR-124, a highly expressed microRNA in the brain, can alleviate neuroinflammation by regulating microglial activation, but its mechanism is unclear. +transcription factor target 34652615 hsa-mir-34 Coronary Stenosis This study is focused on the investigation of vitronectin, miR-193, miR-34, and miR-520 expression levels in PBMCs isolated from stenosed patients. CONCLUSIONS: The molecular events in the vessel stenosis may be affected by targeting vitronectin with miR-520 and miR-34. +transcription factor target 34652615 hsa-mir-520 Coronary Stenosis This study is focused on the investigation of vitronectin, miR-193, miR-34, and miR-520 expression levels in PBMCs isolated from stenosed patients. CONCLUSIONS: The molecular events in the vessel stenosis may be affected by targeting vitronectin with miR-520 and miR-34. +other 34652536 hsa-mir-212 Non-alcoholic Fatty Liver Disease 5p was downregulated in NAFLD patients. +lncRNA target 34652260 hsa-mir-16 Carcinoma, Hepatocellular 5p countervailed the suppressive effect of SNHG22 deficiency on HCC cell proliferation, migration, invasion, and angiogenesis. +lncRNA target 34652259 hsa-mir-24 AIDS-Related Complex Taken together, the enforced expression of circ_EPB41 ameliorated UV irradiation-induced apoptosis of lens epithelial cells by miR3p/BPNT1 pathway, providing us with a potential target for the therapy of UV-caused ARC. +lncRNA target 34652259 hsa-mir-24 UV-Sensitive Syndrome 3p/BPNT1 pathway, providing us with a potential target for the therapy of UV-caused ARC. +genetics_overexpression_promote 34652255 hsa-mir-492 Osteoarthritis In conclusion, hsa_circ_0005567 overexpression promoted M2 macrophage polarization through miR-492/SOCS2 axis to reduced chondrocyte apoptosis, which could inhibit osteoarthritis progression. +target gene 34652079 hsa-mir-766 Triple Negative Breast Neoplasms RMRP promotes the growth, migration, and invasion of TNBC cells via the miR-766-5p/YAP1 axis. +lncRNA target 34651663 hsa-mir-429 Lymphoma, Large B-Cell, Diffuse Therefore, in DLBCL, the tumor suppressor effect of hsamiR429 may be achieved by targeted downregulation of CBX8, suggesting that hsamiR429 may be used as a diagnostic marker and a potential nucleic acid drug for DLBCL. +other 34651657 hsa-mir-181a Liver Cirrhosis Both MALAT1 and miR181a5p expression performed well in their ability to differentiate patients with liver fibrosis from healthy volunteers, and MALAT1 expression was associated with the severity of liver fibrosis. The MALAT1/miR181a5p axis was involved in regulating collagen production and inflammation by activating TLR4/NFkappaB signaling, which may be conducive to liver fibrosis treatment in the future. +lncRNA target 34651293 hsa-mir-30 Colorectal Neoplasms CONCLUSION The microRNA-330 inhibited cell proliferation by suppressing thymidylate synthase (TYMS) in colorectal cancer. +lncRNA target 34651285 hsa-mir-21 Fatty Liver This study examined whether astaxanthin (ASX) could alleviate hepatic steatosis in rats fed a high-fat diet (HFD) by modulating the nuclear factor erythroid 2-related factor 2 (Nrf2)/miR-21 axis. In conclusion, ASX prevents hepatic steatosis mainly by transactivating Nrf2 and is associated with the suppression of miR-21 and Srebp1/2 and upregulation of Pparalpha expression. +lncRNA target 34650983 hsa-mir-146a Carcinoma, Pancreatic Ductal 5p, which may contribute to PDAC pathogenesis and could represent a promising diagnostic biomarker or potential novel therapeutic target in PDAC. +lncRNA target 34650983 hsa-mir-877 Carcinoma, Pancreatic Ductal 5p, which may contribute to PDAC pathogenesis and could represent a promising diagnostic biomarker or potential novel therapeutic target in PDAC. +genetics_knock down_suppress 34650909 hsa-mir-149 Stomach Neoplasms SLCO4A1-AS1 knockdown also determined the function of GC cells but was diminished by the miR-149 inhibitor in vitro. +genetics_overexpression_promote 34650771 hsa-mir-144 Carcinoma, Hepatocellular CONCLUSION: Overexpression of GAS5 upregulates ATF2 through miR +circulation_biomarker_diagnosis_up 34650741 hsa-mir-374a Venous Thrombosis We detected the expression levels of miR-374a-5p in PBMCs and plasma D-dimer of the two groups of patients 1 d before surgery, and 1 d, 3 d, and 5 d after surgery, and analyzed the predictive value, and the correlation between miR-374a-5p and plasma D-dimer for DVT by ROC curve. +target gene 34650713 hsa-mir-145 Psoriasis miR-145-5p inhibits psoriasis progression by regulating the Wnt/β-catenin pathway. +lncRNA target 34650695 hsa-mir-101 Breast Neoplasms The miR3p levels were indirectly proportional to the MALAT1 expressions and the suppressed BC cells. +lncRNA target 34650693 hsa-mir-15a Colonic Neoplasms Finally, inhibiting miR-15a expression largely abolished the effect of SNHG12 silencing on colon cancer cells. In conclusion, our data uncovered the critical role of SNHG12 in the development and progression of colon cancer through regulating the miR-15a/PDK4 axis, therefore providing a promising target for treating this disease. +exosome 34650689 hsa-mir-1913 Osteosarcoma The exosomal transfer of human bone marrow mesenchymal stem cell-derived miR-1913 inhibits osteosarcoma progression by targeting NRSN2. +other 34650687 hsa-mir-29a obsolete Helicobacter pylori infectious disease The miR-29a/MMP9 axis levels were increased in the HP positive patients but not in the HP negative patients. +lncRNA target 34650685 hsa-mir-181b Inflammation Here, up-regulation of miR-181b or down-regulation of HMGB1 exerted similar effects as baicalin and down-regulated miR-181b reversed the anti-inflammatory effect of baicalin in RAW264.7 inflammation models. CONCLUSION: Baicalin can inhibit LPS-induced inflammation in RAW264.7 cells via the miR-181b/HMGB1/TRL4/NF-kappaB pathway. +lncRNA target 34650684 hsa-mir-516a Leukemia, Myeloid, Acute CONCLUSION: Decreased expression of circMYC could suppress AML progression by regulating miR-516a-5p/AKT3, suggesting a new therapeutic target in AML treatment. +lncRNA target 34650682 hsa-mir-34b Dementia, Vascular CONCLUSION: MIAT-containing exo from HNSCs can improve cognitive disorders in VD rats via the miR-34b-5p/CALB1 axis. +lncRNA target 34650682 hsa-mir-34b Cognition Disorders CONCLUSION: MIAT-containing exo from HNSCs can improve cognitive disorders in VD rats via the miR-34b-5p/CALB1 axis. +genetics_knock down_promote 34650680 hsa-mir-542 Colorectal Neoplasms 3p or the overexpression of CREB1 is able to partly weaken the inhibition of CRC cells through the circ_002178 knockdown. +transcription factor target 34650661 hsa-mir-101 Intervertebral Disc Degeneration Our findings demonstrated that miR3p alleviated IDD process through the STC1/VEGF/MAPK pathway. +other 34650644 hsa-mir-132 Cardiomyopathies miR-132 combined with miR-223 can be used for early diagnosis and prognostic evaluation of SIC, and the two are correlated with CK-MB, cTnI, TNF-alpha, and IL-6. +other 34650644 hsa-mir-132 Sepsis miR-132 combined with miR-223 can be used for early diagnosis and prognostic evaluation of SIC, and the two are correlated with CK-MB, cTnI, TNF-alpha, and IL-6. +other 34650644 hsa-mir-223 Cardiomyopathies miR-132 combined with miR-223 can be used for early diagnosis and prognostic evaluation of SIC, and the two are correlated with CK-MB, cTnI, TNF-alpha, and IL-6. +other 34650644 hsa-mir-223 Sepsis miR-132 combined with miR-223 can be used for early diagnosis and prognostic evaluation of SIC, and the two are correlated with CK-MB, cTnI, TNF-alpha, and IL-6. +transcription factor target 34650631 hsa-mir-124 Myocardial Infarction, Acute Together with the GSEA results, which indicated that the differentially expressed genes were mainly enriched in the angiogenesis-inhibiting PI3K/AKT signaling pathway, the present study reported that high expression of miR-124 was negatively associated with patients with AMI, promoting the apoptosis and suppressing the proliferation of vessel endothelial cells. +lncRNA target 34649611 hsa-mir-136 Ovarian Neoplasms CONCLUSIONS: Circ_0061140 silencing repressed the progression and PTX resistance of ovarian cancer by downregulating CBX2 expression via sponging miR-136, which provided novel insight into studying the therapy of ovarian cancer with PTX. +genetics_knock down_promote 34649592 hsa-mir-98 Diabetic Nephropathies Also, NOTCH2 knockdown partly reversed miR +lncRNA target 34649564 hsa-mir-31 Osteoarthritis 3p/PIK3R3 ceRNA axis in HAC, and its inhibition might be one mechanism of HAC injury in OA. +lncRNA target 34649564 hsa-mir-31 Hypoadrenocorticism, Familial 3p/PIK3R3 ceRNA axis in HAC, and its inhibition might be one mechanism of HAC injury in OA. +other 34649241 hsa-mir-149 Coronary Artery Disease The expression patterns of circ_ROBO2 and miR-149 in CAD patients and PDGF-BB-treated human aortic smooth muscle cells (HASMCs) were upregulated and downregulated, respectively. +circulation_biomarker_diagnosis_up 34648865 hsa-mir-186 Depression Our results indicate that the exosomal SERPINF1 in peripheral blood could serve as a reliable biomarker indicating MDD development, and miR +circulation_biomarker_diagnosis_up 34648162 hsa-mir-369 Nephritis, Interstitial Immunofluorescence, qRT-PCR, and western blot were performed to detect the expression of miR-369, Th1/Th2 biomarkers, endoplasmic reticulum (ER) stress-related genes, and apoptotic genes. +lncRNA target 34648132 hsa-mir-7 Siderosis Our results indicate that selectively inhibiting ferroptosis mediated by a METTL14/KCNQ1OT1/miR +lncRNA target 34648132 hsa-mir-7 Heart Injuries Our results indicate that selectively inhibiting ferroptosis mediated by a METTL14/KCNQ1OT1/miR5p positive feedback loop in cardiomyocytes could provide a new therapeutic approach to control DOX-induced cardiac injury. +other 34647653 hsa-mir-449 Intestinal-Type Sinonasal Adenocarcinoma CONCLUSIONS: A high expression of miR-205 and miR-449 is independent predictors of poor survival for ITAC patients. +other 34647653 hsa-mir-205 Intestinal-Type Sinonasal Adenocarcinoma CONCLUSIONS: A high expression of miR-205 and miR-449 is independent predictors of poor survival for ITAC patients. +other 34647573 hsa-mir-136 Lung Neoplasms 5p/HuR in lung cancer and provide novel evidence for the importance of circRNA as a ceRNA in tumorigenesis. +genetics_GWAS 34647497 hsa-mir-1 Squamous Cell Carcinoma of Head and Neck MicroRNAs (miRNAs) are important epigenetic regulators in head and neck squamous cell carcinoma (HNSCC), with miR-31 being considered an oncomir and miR-375, a tumor suppressor miR, which are up- and down-regulated in HNSCC, respectively. +genetics_GWAS 34647497 hsa-mir-375 Squamous Cell Carcinoma of Head and Neck MicroRNAs (miRNAs) are important epigenetic regulators in head and neck squamous cell carcinoma (HNSCC), with miR-31 being considered an oncomir and miR-375, a tumor suppressor miR, which are up- and down-regulated in HNSCC, respectively. +other 34647243 hsa-mir-185 Venous Thrombosis However, no study has reported the effect of miR-185 on LEDVT. Here, we studied the effects of miR-185 on the PI3K/AKT and MAPK signaling pathways in the LEDVT cells. +genetics_knock down_promote 34647226 hsa-mir-3173 Cholangiocarcinoma Knockdown of SNHG3 expression suppressed malignant phenotypes in CCA cells via the miR +other 34647185 hsa-mir-1 Carcinoma, Squamous Cell, Cutaneous MicroRNA21 and microRNA31 are involved in posttranscriptional regulation of protein expression and could play a relevant role in EMT and cSCC progression. Eight tissue microarrays from 80 consecutive cSCCs were analyzed using LNA-based miRNA in situ hybridization for miRNA21 and miRNA31 evaluation, and immunohistochemistry for MMP-1, MMP-3, PTEN, NOTCH-1, NF-kappaB, p63 and CD31. +other 34647185 hsa-mir-21 Carcinoma, Squamous Cell, Cutaneous MicroRNA21 and microRNA31 are involved in posttranscriptional regulation of protein expression and could play a relevant role in EMT and cSCC progression. Eight tissue microarrays from 80 consecutive cSCCs were analyzed using LNA-based miRNA in situ hybridization for miRNA21 and miRNA31 evaluation, and immunohistochemistry for MMP-1, MMP-3, PTEN, NOTCH-1, NF-kappaB, p63 and CD31. +lncRNA target 34646884 hsa-mir-204 Retinal Diseases Continuous bioinformatics analysis has shown that miR-204 has a significant presence and expression in retinal tissue, and approximately 293 genes are controlled and regulated by miR-204 in this tissue; also, target genes of miR-204 have the potential to develop various retinopathies; thus, a study of related target genes can provide appropriate treatment strategies in the future. +other 34646766 hsa-mir-1271 Breast Neoplasms 3p, miR-487a, and miR-487b as EZH2 regulators. +other 34646755 hsa-mir-944 Papillomavirus Infections From the network, we also noticed that EGFR is regulated by HPV E7 protein and hsa-miR-944. +circRNA target 34646428 hsa-mir-92a-2 Carcinoma, Renal Cell Thus, targeting the novel circAMOTL1L-miR-92a +lncRNA target 34646427 hsa-mir-128 Heart Failure These results indicate that miR-128 inhibition might be a potent therapeutic strategy for maladaptive cardiac remodeling and heart failure. +lncRNA target 34646427 hsa-mir-128 Ventricular Remodeling The aim of the present study was to investigate the role of miR-128 in chronic angiotensin II (Ang II) infusion-induced cardiac remodeling and its underlying mechanism. These results indicate that miR-128 inhibition might be a potent therapeutic strategy for maladaptive cardiac remodeling and heart failure. +other 34646427 hsa-mir-128 Cardiomegaly In vitro experiments of cardiac hypertrophy, apoptosis, and aberrant autophagy were performed in cultured cells after Ang II treatment or transfection of miR-128 antagomir. +genetics_overexpression_promote 34646424 hsa-mir-505 Osteoarthritis While overexpression of circFAM160A2 decreased the production of extracellular matrix (ECM) degrading enzymes and ameliorated chondrocyte apoptosis and mitochondrial dysfunction, inhibition of miR +circulation_biomarker_diagnosis_down 34646415 hsa-mir-382 Atherosclerosis 5p in atherosclerotic serum samples. +exosome 34646393 hsa-mir-124 Glioblastoma Conclusions: In this study, we demonstrated that EV-mediated miR-124 delivery exerted synergistic anti-tumor effects by suppressing the growth of human GBM cells and inhibiting M2 microglial polarization. +other 34646160 hsa-mir-23a Heart Failure In HFrEF patients, baseline miR-23a predicted VO(2)peak response to training. +other 34645975 hsa-mir-432 Breast Neoplasms Taken together, DRAIC sponged miR5p to enhance SLBP expression, by which malignant behaviors of BRCA cells were promoted. +genetics_knock down_promote 34645476 hsa-mir-545 Colorectal Neoplasms 3p was a target of circ_0026416, and rescue experiments indicated that circ_0026416 knockdown blocked CRC development by enriching miR +other 34645448 hsa-mir-146a Periodontitis CONCLUSIONS: The results of this study failed to show the associations of miR-146a level with OPG and RANKL levels and OPG/RANKL ratio in periodontitis after non-surgical periodontal treatment. +other 34644734 hsa-mir-582 Melanoma 3p/E2F3 axis. +lncRNA target 34644678 hsa-mir-188 Adenocarcinoma of Lung Cell functional experiments revealed that lncRNA DARS-AS1 participated in enhancing LUAD proliferation, invasion, and migration by inhibiting miR +lncRNA target 34644206 hsa-mir-122 Carcinoma, Hepatocellular sponge and miR-122 using virus-like particles modified by cell-specific peptides is an effective and convenient strategy to correct microRNA dysregulation in hepatocellular carcinoma cells and is a promising therapeutic strategy for hepatocellular carcinoma. +genetics_GWAS 34643920 hsa-mir-149 Thyroid Neoplasms CONCLUSIONS: miRNA-149 gene SNP rs2292832 was observed in strong association with thyroid cancer. +circulation_biomarker_diagnosis_ns 34643918 hsa-mir-770 Foot Ulcer 5p, miR-661 and miR-571) in serum and tissue samples of T2DM related foot ulcer among Iranian patients. +circulation_biomarker_diagnosis_ns 34643918 hsa-mir-571 Foot Ulcer 5p, miR-661 and miR-571) in serum and tissue samples of T2DM related foot ulcer among Iranian patients. +circulation_biomarker_diagnosis_ns 34643918 hsa-mir-571 Diabetes Mellitus, Type 2 5p, miR-661 and miR-571) in serum and tissue samples of T2DM related foot ulcer among Iranian patients. +circulation_biomarker_diagnosis_ns 34643918 hsa-mir-770 Diabetes Mellitus, Type 2 5p, miR-661 and miR-571) in serum and tissue samples of T2DM related foot ulcer among Iranian patients. +other 34643431 hsa-mir-2187 Rhabdoviridae Infections Upon Siniperca chuatsi rhabdovirus (SCRV) virus infection, the expression levels of MIR2187HG were remarkably enhanced. +lncRNA target 34643375 hsa-mir-92a Colorectal Neoplasms The in vivo and in vitro experimental results showed that LINC01915 inhibited the uptake of CRC-derived EVs by NFs through the miR-92a-3p/KLF4/CH25H axis, thus arresting the angiogenesis and the conversion of NFs into CAFs and in turn prevent tumor growth. These data together supported the inhibiting role of LINC01915 in the conversion of NFs into CAFs triggered by the CRC-derived EVs and the ensuing tumor growth, which may be related to its regulation on the miR-92a-3p/KLF4/CH25H axis. +lncRNA target 34643249 hsa-mir-375 Glioma The present study demonstrated that silencing LINC01138 inhibited aerobic glycolysis and thus reduced glioma cell proliferation, potentially by modulating the miR375/SP1 axis. +lncRNA target 34643247 hsa-mir-373 Prostatic Neoplasms The results demonstrated that the expression levels of SNHG16 and TGFbetaR2 were significantly upregulated in PCa tissues, whereas miR3733p expression was significantly downregulated (P<0.001). Taken together, the results of the present study suggest that SNHG16 promotes the proliferation and migration of PCa cells by targeting the miR3733p/TGFbetaR2/SMAD axis. +lncRNA target 34643245 hsa-mir-153 Lung Neoplasms In conclusion, HHIPAS1 inhibits the EMT and stemness of lung cancer cells by regulating the miR1533p/PCDHGA9 axis. +other 34643214 hsa-mir-940 Squamous Cell Carcinoma of Head and Neck Functional bioinformatics analysis and dual-luciferase reporter assay revealed that E2F2 rs2075993 T>C reduced the stability of E2F2 3'-UTR secondary structure and affected the binding of E2F2 to miR-940, which was up-regulated in HNSCC tumor tissues (P = 2.9e-8) and was correlated with poor overall survival of HNSCC (HR = 1.39, 95% CI = 1.02-1.90). +genetics_knock down_promote 34643163 hsa-mir-137 Carcinoma, Renal Cell Further functional studies demonstrated that the inhibition effect of NNT-AS1 knockdown on ccRCC carcinogenesis could be partially reversed by overexpression of YBX-1, suggesting that NNT-AS1 promotes ccRCC progression through the miR-137/YBX-1 pathway. +transcription factor target 34643044 hsa-mir-146b Atrial Fibrillation The expression of miR-146b-5p, whose the targeted gene is TIMPs, is upregulated in atrial cardiomyocytes during AF. +transcription factor target 34643044 hsa-mir-146b Fibrosis, Atrial The expression of miR-146b-5p, whose the targeted gene is TIMPs, is upregulated in atrial cardiomyocytes during AF. +lncRNA target 34643030 hsa-mir-607 Lung Neoplasms The LINC00115/miR-607/ITGB1 signaling axis might be a novel therapeutic target in lung cancer. +other 34641879 hsa-mir-125a Adenocarcinoma of Lung Circular RNA hsa_circ_0002483 promotes growth and invasion of lung adenocarcinoma by sponging miR-125a-3p. +lncRNA target 34641738 hsa-mir-21 Diabetic Nephropathies In this study, we have investigated the role of miR-21 on l-thyroxine (l-Thy)-induced cardiac fibrosis in rats. In conclusion, l-Thy-induced LV remodeling and fibrosis include a ROS-dependent upregulation of miR-21 which in turns activates NF-kappaB/NRLP3 inflammasome and suppresses SMad7. +lncRNA target 34641698 hsa-mir-424 Urinary Bladder Neoplasms LINC00355 promoted migration, invasion, and EMT ability of bladder cancer through elevating HMGA2 expression via acting as a sponge for miR +circulation_biomarker_diagnosis_up 34641696 hsa-mir-27b Stomach Neoplasms The results showed that hsa_circ_0006470 expression was significantly elevated in GC cells, which was mainly distributed in cytoplasmic components and could directly bind with miR-27b-3p in GC cells. +genetics_GWAS 34641388 hsa-mir-155 COVID-19 dioca aqueous extract, ferulic acid 1, rutin 2, gallic acid 3, and chlorogenic acid 4 were recorded through measuring TNF-alpha, IL-1beta, IL-2, IL-10, G-CSF, and genetic expression of miRNA 21-3P and miRNA-155 levels to assess their anti-inflammatory effects essential for COVID-19 patients. +genetics_GWAS 34641388 hsa-mir-21 COVID-19 dioca aqueous extract, ferulic acid 1, rutin 2, gallic acid 3, and chlorogenic acid 4 were recorded through measuring TNF-alpha, IL-1beta, IL-2, IL-10, G-CSF, and genetic expression of miRNA 21-3P and miRNA-155 levels to assess their anti-inflammatory effects essential for COVID-19 patients. +tissue_expression_ns 34639126 hsa-mir-223 Thiamine Deficiency The mechanism research revealed that BAP31-deficiency decreased Nrf2 mRNA stability (half-life of Nrf2 mRNA decreased from ~1.3 h to ~40 min) and miR-223 expression, led to reduced nuclear factor erythroid 2-related factor 2 (Nrf2) signaling activation and antioxidant genes induction. +transcription factor target 34639051 hsa-mir-24 Heart Failure In conclusion, HF progression following DOX administration can be prevented or even delayed by targeting miR-24 and its downstream JP-2. +other 34638938 hsa-mir-483 Gastrointestinal Stromal Tumors Using an extended series of GIST samples, we further validated the downregulation of miR3p in imatinib-treated GIST samples by RT-qPCR. +transcription factor target 34638915 hsa-mir-29a Cardiomyopathies miR-29a-3p targeted THBS2 expression via a direct anti-fibrotic effect on PAH-induced cardiac fibrosis, indicating miR-29a-3p acts as a messenger with promising therapeutic effects. +circulation_biomarker_diagnosis_ns 34638892 hsa-mir-126 Renal Insufficiency, Chronic miR-126 is a regulator of endothelial dysfunction and its blood level is decreased in CKD patients. In order to obtain a better understanding of the physiopathology of the disease, we correlated the levels of miR-126 with several markers of endothelial dysfunction, as well as the representative uremic toxins, in a large cohort of CKD patients at all stages of the disease. +other 34638892 hsa-mir-9 Renal Insufficiency, Chronic An association of miR-126 with all the evaluated uremic toxins was also found, while uremic toxins were not associated with the internal control, specifically cel-miR-39. +lncRNA target 34638868 hsa-mir-155 Cardiovascular Diseases Taken together, these results are the first to elucidate the role of HDAC6 in unloading-induced cell growth inhibition through the miR +other 34638838 hsa-mir-28 Diabetic Retinopathy A panel of three miRNAs (hsa-let-7a-5p, hsa-miR-novel-chr5_15976, and hsa-miR3p) demonstrated a good sensitivity and specificity for predicting T2DR. +other 34638838 hsa-let-7a Diabetic Retinopathy A panel of three miRNAs (hsa-let-7a-5p, hsa-miR-novel-chr5_15976, and hsa-miR3p) demonstrated a good sensitivity and specificity for predicting T2DR. +circulation_biomarker_diagnosis_ns 34638717 hsa-mir-22 Heart Failure In conclusion, circulating miR-199a-5p and miR +circulation_biomarker_diagnosis_ns 34638717 hsa-mir-199a Heart Failure In conclusion, circulating miR-199a-5p and miR +circulation_biomarker_diagnosis_ns 34638717 hsa-mir-199a Atrial Fibrillation In conclusion, circulating miR-199a-5p and miR +circulation_biomarker_diagnosis_ns 34638717 hsa-mir-22 Atrial Fibrillation In conclusion, circulating miR-199a-5p and miR +other 34638691 hsa-mir-20a Respiratory Insufficiency In conclusion, our analysis underlines the importance of thromboembolic processes in patients with respiratory failure and emphasizes miRNA-320s as potential biomarkers for severe progressive SARS-CoV-2 infection. +other 34638691 hsa-mir-20a COVID-19 In conclusion, our analysis underlines the importance of thromboembolic processes in patients with respiratory failure and emphasizes miRNA-320s as potential biomarkers for severe progressive SARS-CoV-2 infection. +exosome 34638684 hsa-mir-221 Obesity, Maternal miRNA detection showed that miR-221, one of the miRNAs, was significantly enriched in exosomes from obese sows. +lncRNA target 34638550 hsa-mir-21 Colorectal Neoplasms The elevation of miR21 expression was upstream of the phosphatase and tensin homolog (PTEN) inhibition, and CRC cell proliferation enhancement that was shown to be possibly mediated by PI3K/AKT signaling activation. +other 34638505 hsa-mir-552 Colorectal Neoplasms Finally, we identified that microRNA miR-552 negatively regulates ACKR4 expression in human CRC. +lncRNA target 34638504 hsa-mir-200c Prostatic Neoplasms, Castration-Resistant Mechanistically, we found that: (1) TBX2 binds to the promoter and represses the expression of miR-200c-3p, a miR reported to be lost in castrate resistant prostate cancer (CRPC), and (2) the repression of miR-200c-3p results in the increased expression of its targets SOX2 and N-MYC. +other 34638487 hsa-mir-199b Rectal Neoplasms microRNA-199b as A Promising Predictor of Outcome and Response to Neoadjuvant Treatment in Locally Advanced Rectal Cancer Patients. +target gene 34638478 hsa-mir-27a Colorectal Neoplasms The miR-27a/FOXJ3 Axis Dysregulates Mitochondrial Homeostasis in Colorectal Cancer Cells. +other 34638467 hsa-mir-21 Inflammation In the liver, miR-21 was reported to promote hepatic steatosis and inflammation, but whether miR-21 also drives hepatocarcinogenesis remains poorly investigated in vivo. +other 34638467 hsa-mir-21 Fatty Liver In the liver, miR-21 was reported to promote hepatic steatosis and inflammation, but whether miR-21 also drives hepatocarcinogenesis remains poorly investigated in vivo. +target gene 34638401 hsa-mir-125b Carcinoma, Hepatocellular In conclusion, miR-125b-5p suppressed ataxin-1 and consequently induced Snail-mediated EMT and stemness, leading to a poor prognosis in HCC patients. +other 34638231 hsa-mir-145 Penile Neoplasms 5p) and six upregulated DEGs (IL1A, MCM2, MMP1, MMP12, SFN and VEGFA) as potential biomarkers in PeC by their capacity of discriminating TT and NNT with accuracy. +other 34638231 hsa-mir-487b Penile Neoplasms 5p) and six upregulated DEGs (IL1A, MCM2, MMP1, MMP12, SFN and VEGFA) as potential biomarkers in PeC by their capacity of discriminating TT and NNT with accuracy. +other 34638231 hsa-mir-432 Penile Neoplasms 5p) and six upregulated DEGs (IL1A, MCM2, MMP1, MMP12, SFN and VEGFA) as potential biomarkers in PeC by their capacity of discriminating TT and NNT with accuracy. +lncRNA target 34637688 hsa-mir-1224 Polycystic Ovary Syndrome 5p might be a promising target for treating PCOS. +lncRNA target 34637682 hsa-mir-628 Stomach Neoplasms Our findings identify a novel ceRNA network, the circ_HN1/miR5p/NT5E axis, for the oncogenic activity of circ_HN1 in gastric cancer, highlighting circ_HN1 inhibition as a promising targeted treatment against gastric cancer. +other 34637672 hsa-mir-127 Osteosarcoma In conclusion, circFOXP1 promoted angiogenesis by regulating miR5p/CDKN2AIP signaling pathway in osteosarcoma. +circulation_biomarker_diagnosis_ns 34637043 hsa-mir-483 Pneumonia The expression of serum miR +circulation_biomarker_diagnosis_ns 34637043 hsa-mir-483 Respiratory Insufficiency The expression of serum miR +exosome 34637033 hsa-mir-223 Periodontitis 3p expression in salivary exosomes could be used as an important non-invasive method to diagnose and evaluate the severity of periodontitis. +transcription factor target 34636482 hsa-mir-34c Sialorrhea The current study explores the involvement of miR-34b/miR-34c in mucus hypersecretion in RSV-infected airway epithelial cells by targeting FGFR1. +transcription factor target 34636482 hsa-mir-34b Sialorrhea The current study explores the involvement of miR-34b/miR-34c in mucus hypersecretion in RSV-infected airway epithelial cells by targeting FGFR1. +transcription factor target 34636482 hsa-mir-34c Respiratory Syncytial Virus Infections The current study explores the involvement of miR-34b/miR-34c in mucus hypersecretion in RSV-infected airway epithelial cells by targeting FGFR1. This study identified that miR-34b/miR-34c was involved in c-Jun-regulated MUC5AC production by targeting FGFR1 in RSV-infected airway epithelial cells. +transcription factor target 34636482 hsa-mir-34b Respiratory Syncytial Virus Infections The current study explores the involvement of miR-34b/miR-34c in mucus hypersecretion in RSV-infected airway epithelial cells by targeting FGFR1. This study identified that miR-34b/miR-34c was involved in c-Jun-regulated MUC5AC production by targeting FGFR1 in RSV-infected airway epithelial cells. +lncRNA target 34636432 hsa-mir-126 Lung Neoplasms Paeonol inhibits human lung cancer cell viability and metastasis via the miR +other 34636395 hsa-mir-214 Carcinoma, Hepatocellular These findings suggest that the BACE1-AS/miR3p/APLN axis is a novel signaling pathway that facilitates HCC. +other 34636389 hsa-mir-146a Depression In addition, curcumin attenuated the increases in levels of miR-146a-5p and decreases in the expression of p-ERK signaling that would normally occur within CA1 regions of these depressed rats. +transcription factor target 34636136 hsa-mir-363 Glioma 3p expression inhibited glioma cell proliferation and invasion, as well as promoted cell death via attenuating EMT and blocking the Wnt/beta-catenin pathway. +genetics_overexpression_promote 34636093 hsa-mir-29a Ameloblastoma RESULTS: miR-29a-3p was overexpressed in AB tissues, which promoted the migration and invasion of AB cells in vitro. +other 34635862 hsa-mir-494 Spinal Cord Injuries As confirmed by existing studies, miR-494 is important to regulate the occurrence, progression, and repair of spinal cord injury (SCI). +exosome 34635639 hsa-mir-1305 Colorectal Neoplasms Upregulated circCOG2 promoted CRC proliferation, migration, and invasion through the miR-1305/TGF-beta2/SMAD3 pathway, and this effect could be transmitted from CRC cells with the high metastatic potential to CRC cells with low metastatic potential by exosomes. +transcription factor target 34635014 hsa-mir-19b Adenocarcinoma of Lung These findings suggested miR-19b-3p/GNG7 axis contributed to the progression of LUAD through Hedgehog signaling, which might be a potential therapeutic target for LUAD treatment. +lncRNA target 34635009 hsa-mir-409 Osteosarcoma In conclusion, circATRNL1 promoted osteosarcoma progression by enhancing glycolysis via circATRNL1/miR +other 34634995 hsa-mir-144 Carcinoma, Hepatocellular 3p/WTAP axis as downstream effectors mediating the oncogenic function of LINC00839. +exosome 34634686 hsa-mir-501 Urinary Incontinence, Stress Collectively, our present results provide new insights into the promyogenic mechanism of M2 macrophages and prove that M2 macrophage exosomal miR-501 may represent a potential therapeutic to promote recovery from diseases caused by muscle injury, including SUI. +exosome 34634686 hsa-mir-501 Muscular Diseases Collectively, our present results provide new insights into the promyogenic mechanism of M2 macrophages and prove that M2 macrophage exosomal miR-501 may represent a potential therapeutic to promote recovery from diseases caused by muscle injury, including SUI. +genetics_overexpression_promote 34634673 hsa-mir-587 Adenocarcinoma of Lung Functional assays revealed that circZMYM4 overexpression suppressed LUAD cell proliferation, metastasis and suppressed apoptosis, while miR-587 overexpression could weaken these effects. +exosome 34634611 hsa-mir-27a Hemangioma, Cavernous Here, we aimed to investigate the relationship between TAMs-derived exosomal miR-27a-3p and propranolol sensitivity in IH. +circulation_biomarker_diagnosis_ns 34633737 hsa-mir-687 Liver Injury NEW FINDINGS What is the central question of this study? What is the role of circulating exosomal miR-687 in remote hepatic injury following renal ischaemia-reperfusion injury (IRI) and does thymoquinone have a modulatory impact? What is the main finding and its importance? Exosomal miR-687 was expressed in renal IRI, entered the circulation and was deposited in the liver. +genetics_knock down_promote 34633608 hsa-mir-138 Retinoblastoma 5p overexpression-mediated effects in RB cells. +transcription factor target 34633468 hsa-mir-451 Myocardial Reperfusion Injury CONCLUSIONS: miR3p played a protective role in MIRI via inhibiting MAP1LC3B-mediated autophagy, which may provide new molecular targets for the treatment of MIRI and further improves the clinical outcomes of heart diseases. +genetics_knock down_promote 34633248 hsa-mir-101 Osteoarthritis 3p using bioinformatics analysis and luciferase reporter assays, performed loss- and gain-of-function analyses. +other 34633138 hsa-mir-424 Osteochondrodysplasias Moreover, miR-424/503 cluster is required for Wnt-mediated MaSC expansion induced by the ovarian cycles. These results unveil an unknown link between the miR-424/503, regulation of Wnt signaling, MaSC fate, and tumorigenesis. +lncRNA target 34633056 hsa-mir-29c Carcinoma, Hepatocellular Collectively, the results of the present study revealed that CRNDE was upregulated and exerted an oncogenic role in HCC by targeting miR29c3p, and that the upregulation of CRNDE also promoted NASP expression. +lncRNA target 34633056 hsa-mir-29c Colorectal Neoplasms Collectively, the results of the present study revealed that CRNDE was upregulated and exerted an oncogenic role in HCC by targeting miR29c3p, and that the upregulation of CRNDE also promoted NASP expression. +lncRNA target 34632963 hsa-mir-1322 Colorectal Neoplasms nucleatum infection decreased the expression of miR-1322 by activating the NF-kappaB signaling pathway in CRC cells. nucleatum promotes CRC metastasis through the miR-1322/CCL20 axis and M2 polarization. +genetics_overexpression_promote 34632938 hsa-mir-199a Adenocarcinoma of Lung Additionally, miR-199a-3p overexpression inhibited the growth of LUAD cells in vitro and in vivo, while elevating the apoptosis rate of the cells. +genetics_overexpression_promote 34632932 hsa-mir-188 Myocardial Ischemia Silencing LncGAS5 and SMAD2 or overexpressing miR +lncRNA target 34632867 hsa-mir-23b Osteosarcoma Upregulation of miR-23b-3p not only inhibited the expression of ADD3, but also released the tumor suppressive role of ADD3 on the proliferation and migration of osteosarcoma cells. +genetics_knock down_promote 34632534 hsa-mir-590 Breast Neoplasms 5p inhibition reversed the inhibitory effects of circ_0069718 knockdown on BC cell-aggressive oncogenic phenotypes; moreover, miR +lncRNA target 34632168 hsa-mir-499a Ischemic Stroke This study aimed to test our hypothesis that a miR-499a played an important role in the inflammatory response in astrocytes induced by IS targeting phosphatase and tensin homologue deleted on chromosome 10 (PTEN). +genetics_GWAS 34632051 hsa-mir-16 Cholangiocarcinoma Taken together, our new findings suggested that IDH1 mutation-induced R-2HG could suppress CCA growth via regulating the FTO/m6A-methylated ERalpha/miR16-5p/YAP1 signaling pathway. +lncRNA target 34631898 hsa-mir-145 Stomach Neoplasms Inhibition of circCOL1A1/miR-145/RABL3 could effectively suppress gastric cancer cell proliferation, migration, and invasion. +circulation_biomarker_diagnosis_up 34631883 hsa-mir-92a Endometriosis 3p in both plasma and eMSCs and revealed their possible role in endometriosis based on in silico analysis. +target gene 34631548 hsa-mir-135a Multiple Myeloma Bortezomib Inhibits Multiple Myeloma Cells by Transactivating ATF3 to Trigger miR-135a-5p- Dependent Apoptosis. +other 34631347 hsa-mir-6791 Breast Neoplasms Overall the study first time reports the association of four miRNAs (miR-6791, miR-4419a, miR-4251 and miR-6844) with breast cancer stemness. +other 34631347 hsa-mir-6844 Breast Neoplasms The miR-6844 showed significantly high expression in various clinical subgroups of invasive breast cancer patients compared with the normal samples. Overall the study first time reports the association of four miRNAs (miR-6791, miR-4419a, miR-4251 and miR-6844) with breast cancer stemness. +other 34631347 hsa-mir-4419a Breast Neoplasms Overall the study first time reports the association of four miRNAs (miR-6791, miR-4419a, miR-4251 and miR-6844) with breast cancer stemness. +other 34631347 hsa-mir-4251 Breast Neoplasms Overall the study first time reports the association of four miRNAs (miR-6791, miR-4419a, miR-4251 and miR-6844) with breast cancer stemness. +other 34631281 hsa-mir-4677 Arteriosclerosis Obliterans 3p/USP9X axis to accelerate the proliferation and migration of VSMCs in the in vitro model of ASO of the lower extremities. +other 34631281 hsa-mir-889 Arteriosclerosis Obliterans 3p/USP9X axis to accelerate the proliferation and migration of VSMCs in the in vitro model of ASO of the lower extremities. +circRNA target 34631278 hsa-mir-326 Glioblastoma 5p/SMAD6 signaling axis could be a potential target for GBM treatment. +circRNA target 34631278 hsa-mir-30 Glioblastoma 5p/SMAD6 signaling axis could be a potential target for GBM treatment. +lncRNA target 34631276 hsa-mir-20a Diabetes Mellitus However, the direct role of miR-320a in the pathophysiology of pancreatic beta cells under diabetes mellitus remains unclear. Our data suggested that miR-320a could damage the pancreatic beta cells directly and might be a potential therapeutic target of diabetes. +other 34631221 hsa-mir-210 Colorectal Neoplasms Therefore, the HIF-1alpha/miR-210/VMP1 pathway might regulate the migration and invasion of CAFs in CRC. +lncRNA target 34631221 hsa-mir-210 Double Outlet Right Ventricle In vivo, inhibition of miR-210 expression in CAFs reduced the metastasis of CAFs and tumour cells. +other 34630982 hsa-mir-511 Goiter The results showed that SHB prescription ameliorated goiter and downregulated miR3p. +genetics_overexpression_suppress 34630738 hsa-mir-141 Ulcerative Colitis In summary, the overexpression of H19 in MSC downregulated miR-139 and miR-141, thus increasing the activity of their targets ICAM-1 and CXCR4, respectively, to exhibit therapeutic effects in ulcerative colitis. +genetics_overexpression_suppress 34630738 hsa-mir-139 Ulcerative Colitis In summary, the overexpression of H19 in MSC downregulated miR-139 and miR-141, thus increasing the activity of their targets ICAM-1 and CXCR4, respectively, to exhibit therapeutic effects in ulcerative colitis. +genetics_overexpression_promote 34630715 hsa-mir-135a Carcinoma, Hepatocellular Notably, overexpression of TONSL-AS1 inhibited HCC cell proliferation, while overexpression of miR-135a promoted HCC cell proliferation and decreased the effect of overexpression of TONSL-AS1 on cell proliferation. Taken together, the results of the present study suggest that miR-135a expression is upregulated in HCC and targets lncRNA TONSL-AS1 to suppress cell proliferation. +genetics_GWAS 34630712 hsa-mir-152 Prostatic Neoplasms The present study investigated the 'epigenetic-based miRNA (epi-miRNA)-mRNA' regulatory network of miR-34b, miR-34c, miR-148a, miR-152, miR-200a and miR-200b epi-miRNAs and their target genes, DNA methyltransferase (DNMT1, 3a and 3b), phosphate and tensin homolog (PTEN) and NK3 Homeobox 1 (NKX3.1), in prostate cancer (PCa) using reverse transcription-quantitative PCR. +genetics_GWAS 34630712 hsa-mir-34b Prostatic Neoplasms The present study investigated the 'epigenetic-based miRNA (epi-miRNA)-mRNA' regulatory network of miR-34b, miR-34c, miR-148a, miR-152, miR-200a and miR-200b epi-miRNAs and their target genes, DNA methyltransferase (DNMT1, 3a and 3b), phosphate and tensin homolog (PTEN) and NK3 Homeobox 1 (NKX3.1), in prostate cancer (PCa) using reverse transcription-quantitative PCR. +genetics_GWAS 34630712 hsa-mir-200a Prostatic Neoplasms The present study investigated the 'epigenetic-based miRNA (epi-miRNA)-mRNA' regulatory network of miR-34b, miR-34c, miR-148a, miR-152, miR-200a and miR-200b epi-miRNAs and their target genes, DNA methyltransferase (DNMT1, 3a and 3b), phosphate and tensin homolog (PTEN) and NK3 Homeobox 1 (NKX3.1), in prostate cancer (PCa) using reverse transcription-quantitative PCR. +genetics_GWAS 34630712 hsa-mir-34c Prostatic Neoplasms The present study investigated the 'epigenetic-based miRNA (epi-miRNA)-mRNA' regulatory network of miR-34b, miR-34c, miR-148a, miR-152, miR-200a and miR-200b epi-miRNAs and their target genes, DNA methyltransferase (DNMT1, 3a and 3b), phosphate and tensin homolog (PTEN) and NK3 Homeobox 1 (NKX3.1), in prostate cancer (PCa) using reverse transcription-quantitative PCR. +genetics_GWAS 34630712 hsa-mir-200b Prostatic Neoplasms The present study investigated the 'epigenetic-based miRNA (epi-miRNA)-mRNA' regulatory network of miR-34b, miR-34c, miR-148a, miR-152, miR-200a and miR-200b epi-miRNAs and their target genes, DNA methyltransferase (DNMT1, 3a and 3b), phosphate and tensin homolog (PTEN) and NK3 Homeobox 1 (NKX3.1), in prostate cancer (PCa) using reverse transcription-quantitative PCR. +genetics_GWAS 34630712 hsa-mir-148a Prostatic Neoplasms The present study investigated the 'epigenetic-based miRNA (epi-miRNA)-mRNA' regulatory network of miR-34b, miR-34c, miR-148a, miR-152, miR-200a and miR-200b epi-miRNAs and their target genes, DNA methyltransferase (DNMT1, 3a and 3b), phosphate and tensin homolog (PTEN) and NK3 Homeobox 1 (NKX3.1), in prostate cancer (PCa) using reverse transcription-quantitative PCR. +genetics_knock down_promote 34630709 hsa-mir-204 Squamous Cell Carcinoma of Head and Neck Knockdown of NEAT1 using small interfering (si) RNA and overexpressed miR +genetics_overexpression_promote 34630706 hsa-mir-34b Leukemia, Myeloid, Acute Moreover, AML cell proliferation was increased by circ-ATAD1 overexpression, but decreased by miR-34b overexpression, and the effect of circ-ATAD1 overexpression on AML cell proliferation was reduced by miR-34b overexpression. +circulation_biomarker_prognosis_ns 34630703 hsa-mir-210 Carcinoma, Non-Small-Cell Lung The results demonstrated that 4/12 plasma miRNAs (miR-210, miR-1290, miR-150 and miR +circulation_biomarker_prognosis_ns 34630703 hsa-mir-150 Carcinoma, Non-Small-Cell Lung The results demonstrated that 4/12 plasma miRNAs (miR-210, miR-1290, miR-150 and miR +circulation_biomarker_prognosis_ns 34630703 hsa-mir-21 Carcinoma, Non-Small-Cell Lung The results demonstrated that 4/12 plasma miRNAs (miR-210, miR-1290, miR-150 and miR +circulation_biomarker_prognosis_ns 34630703 hsa-mir-1290 Carcinoma, Non-Small-Cell Lung The results demonstrated that 4/12 plasma miRNAs (miR-210, miR-1290, miR-150 and miR +genetics_overexpression_suppress 34630696 hsa-mir-665 Retinoblastoma Furthermore, the proliferation and migratory and invasive abilities of Rb Y79 and HXO-RB44 cells were decreased following MIAT downregulation or miR-665 overexpression. +lncRNA target 34630694 hsa-mir-23b Osteoporosis In conclusion, lncRNA RP11-84C13.1 upregulated RUNX2 by absorbing miRNA-23b-3p, and thus induced hBMSC osteogenesis to alleviate osteoporosis. +target gene 34630682 hsa-mir-515 Breast Neoplasms miR-515-5p inhibits the proliferation, migration and invasion of human breast cancer cells by targeting CBX4. +transcription factor target 34630677 hsa-mir-489 Inflammation 3p may represent a novel therapeutic target for the treatment of IDD. +target gene 34630673 hsa-mir-638 Ovarian Neoplasms miR-638 suppresses proliferation by negatively regulating high mobility group A1 in ovarian cancer cells. +lncRNA target 34630672 hsa-mir-18a Cicatrix Therefore, miR-18a-5p may serve as a novel therapeutic target for the treatment of HS. +genetics_overexpression_promote 34630658 hsa-mir-144 Nasopharyngeal Carcinoma Furthermore, the downregulation of IRS-1 by miR-144 decreased the expression level of dishevelled 2 (Dvl2) protein without affecting its mRNA level, and Dvl2 overexpression abolished the inhibitory effect of the miR-144 mimic in NPC, indicating that miR-144 potentially regulates NPC by indirectly regulating Dvl2. +lncRNA target 34630643 hsa-mir-24 Myocardial Reperfusion Injury Overall, the present results suggested that miR-24 improves myocardial injury in rats by inhibiting the NF-kappaB/TNF-alpha pathway. +genetics_knock down_promote 34630639 hsa-mir-1181 Carcinoma, Non-Small-Cell Lung In addition, overexpression of miR-1181 exerted enhancing effects on cell proliferation, migration and invasion of NSCLC, while its knockdown inhibited these cellular processes. +other 34630590 hsa-mir-21 Leishmaniasis BACKGROUND: Leishmaniasis is characterized by strong inflammatory responses with high levels of inflammatory cytokines that induce microRNA 21 and matrix metalloproteinases. +lncRNA target 34630130 hsa-mir-204 Pre-Eclampsia The network connecting the 37 target genes for miR5p revealed pathways of known pathophysiological relevance during the early development of PE and included key genes related to PE, such as BDNF, MMP-9, MALAT1, TGFBR2, and SIRT1. +lncRNA target 34630099 hsa-mir-204 Insulinoma Therefore, we speculate that miR-204 may be the upstream regulatory target of SIRT1 in islets and thus participate in the occurrence of beta-cell dysfunction. +genetics_overexpression_promote 34630099 hsa-mir-204 Hyperlipoproteinemia Type III SIRT1 overexpression reversed the damage to beta-cells caused by miR-204. +other 34630099 hsa-mir-204 Diabetes Mellitus, Type 2 Our study identifies a novel correlation between miR-204 and beta-cell dysfunction in T2DM and shows that administration of BBR leads to remission of beta-cell dysfunction by regulating the miR-204/SIRT1 pathway. +genetics_knock down_suppress 34629901 hsa-mir-144 Stomach Neoplasms CONCLUSION: HCG11 knockdown attenuated DDP resistance of GC cells through via miR +other 34629898 hsa-mir-215 Carcinoma, Hepatocellular The prediction of lncRNA RUSC1-AS1/hsa-miR5p/LRP1B axis by bioinformatics may be the potential mechanism underlying LRP1B's effect on HCC prognosis and progression. +lncRNA target 34629895 hsa-mir-338 Brain Ischemia CASC15/miR3p/ETS1 axis played an essential role in cell viability, apoptosis, and neuroinflammation. +lncRNA target 34629895 hsa-mir-338 Ischemic Stroke CASC15/miR3p/ETS1 axis played an essential role in cell viability, apoptosis, and neuroinflammation. +exosome 34629821 hsa-mir-588 Stomach Neoplasms CONCLUSION: In conclusion, we uncovered that exosomal miR-588 from M2 macrophages contributes to DDP resistance of gastric cancer cells by partly targeting CYLD. +lncRNA target 34629820 hsa-mir-20b Colorectal Neoplasms In addition, miR-20b-3p expression in CRC patients was also reduced and negatively correlated with circ_0084927 expression. Moreover, circ_0084927 potentially regulates CRC cell migration and invasion via the miR-20b-3p/GSTM5/ AKT/mTOR pathway. +lncRNA target 34629748 hsa-mir-200b Inflammatory Bowel Diseases MiR-200b-3p alleviates UC by negatively regulating KHDRBS1. +transcription factor target 34629418 hsa-mir-16 Macular Degeneration We hypothesize that Hsa-miR5p might target four out of the five key DEGs in the AMD RPE. +circulation_biomarker_diagnosis_ns 34629299 hsa-mir-371a Testicular Neoplasms CONCLUSION: Quantifying circulating miR-371a-3p alone is sufficient for testicular MGCT diagnosis. +genetics_GWAS 34629216 hsa-mir-143 Glomus Tumor In fact, glomus tumor involves frequent MIR143-NOTCH gene fusion whereas others pericytic tumor (myopericytoma and myofibroma) involve mutations of PDGFRB gene. Next Generation molecular analysis using RNA sequencing highlighted the characteristic MIR143-NOTCH gene fusion witch supports the diagnosis of glomus tumor. +circulation_biomarker_diagnosis_up 34629107 hsa-mir-1260b Ovarian Neoplasms We investigated the expression levels of miR-1260a, and miR-1260b miRNAs, in the peripheral blood lymphocytes of 150 familial and sporadic ovarian cancer patients, and of 100 healthy individuals of the control group who were matched for age, sex, and ethnicity with the patient group, and investigated their possible property of being a biologic indicator for ovarian cancer. +other 34629037 hsa-mir-7 Osteoarthritis In summary, miR-7/EGFR/MEGF9 axis may perform a crucial function in the regulation of OA, providing potential for OA treatment. +genetics_knock down_promote 34628789 hsa-mir-21 Glioma In rescue experiments, knockdown of TET1 neutralized miR +lncRNA target 34628519 hsa-mir-582 Melanoma Low expression of miR-582 is associated with prognosis and progression of melanoma by targeting FOXC1. +lncRNA target 34628269 hsa-mir-9 Osteoarthritis 5p was highly expressed in the synovial tissues of the OA model and was positively associated with M1 markers. +circulation_biomarker_diagnosis_ns 34628264 hsa-mir-150 Carcinoma, Renal Cell RESULTS: Six serum miRNAs (miR +circulation_biomarker_diagnosis_ns 34628264 hsa-mir-145 Carcinoma, Renal Cell RESULTS: Six serum miRNAs (miR +circulation_biomarker_diagnosis_ns 34628264 hsa-mir-21 Carcinoma, Renal Cell RESULTS: Six serum miRNAs (miR +circulation_biomarker_diagnosis_ns 34628264 hsa-mir-146a Carcinoma, Renal Cell RESULTS: Six serum miRNAs (miR +genetics_GWAS 34628001 hsa-mir-206 Depression In contrast, both genetic knockdown of hippocampal miR +genetics_knock down_suppress 34627697 hsa-mir-153 Atherosclerosis CONCLUSION: PVT1 knockdown alleviated ox-LDL-induced vascular endothelial cell injury and atherosclerosis through miR3p/GRB2 axis via ERK1/2 and p38 pathway. +lncRNA target 34627683 hsa-let-7b Hodgkin Disease Let-7b-5p holds the central position in the regulatory network of miRNA-mRNA interactions, has the highest number of mRNA target genes shared with the other differentially expressed miRNAs and is significantly downregulated in Hodgkin lymphoma follicular fluid samples. +circulation_biomarker_diagnosis_up 34627442 hsa-mir-205 Thrombocytopenia 5p,miR-326,miR-1827,mi and Th1-specific transcription factor T-bet mRNA and Th2-specific transcription factor GATA-3 mRNA in the peripheral blood of the two groups. +circulation_biomarker_diagnosis_up 34627442 hsa-mir-138 Thrombocytopenia 5p,miR-326,miR-1827,mi and Th1-specific transcription factor T-bet mRNA and Th2-specific transcription factor GATA-3 mRNA in the peripheral blood of the two groups. +circulation_biomarker_diagnosis_up 34627442 hsa-mir-1827 Thrombocytopenia 5p,miR-326,miR-1827,mi and Th1-specific transcription factor T-bet mRNA and Th2-specific transcription factor GATA-3 mRNA in the peripheral blood of the two groups. +circulation_biomarker_diagnosis_up 34627442 hsa-mir-107 Thrombocytopenia 5p,miR-326,miR-1827,mi and Th1-specific transcription factor T-bet mRNA and Th2-specific transcription factor GATA-3 mRNA in the peripheral blood of the two groups. +lncRNA target 34627424 hsa-mir-652 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 5p and deregulates the translational inhibition of P62 mRNA, thus to increase ROS content in mitochondria of T-ALL cells. +circulation_biomarker_diagnosis_down 34627193 hsa-mir-485 Glioblastoma 5p/CSF-1 axis, and circCDC45 might be a promising plasmatic biomarker for GBM diagnosis and treatment. +genetics_overexpression_promote 34627051 hsa-mir-10b Craniosynostosis radial aplasia syndrome In addition, overexpression of PAI-1 significantly inhibited BGC apoptosis (P < 0.05), and PAI-1 could alleviate BGC apoptosis induced by miR-10b (P < 0.05). +other 34626953 hsa-mir-370 Melanoma 5p/miR-370 may contribute to melanomagenesis by triggering the EMT signaling pathway and VM formation. +other 34626953 hsa-mir-563 Melanoma 5p/miR-370 may contribute to melanomagenesis by triggering the EMT signaling pathway and VM formation. +other 34626953 hsa-mir-770 Melanoma 5p/miR-370 may contribute to melanomagenesis by triggering the EMT signaling pathway and VM formation. +other 34626953 hsa-mir-770 Vitelliform Macular Dystrophy 5p/miR-370 may contribute to melanomagenesis by triggering the EMT signaling pathway and VM formation. +other 34626953 hsa-mir-370 Vitelliform Macular Dystrophy 5p/miR-370 may contribute to melanomagenesis by triggering the EMT signaling pathway and VM formation. +other 34626953 hsa-mir-563 Vitelliform Macular Dystrophy 5p/miR-370 may contribute to melanomagenesis by triggering the EMT signaling pathway and VM formation. +genetics_overexpression_promote 34626803 hsa-mir-375 Nasopharyngeal Carcinoma Further experiments revealed that up-regulated miR-375 expression led to USP1 down-regulation, and miR-375 overexpression suppressed PI3K/Akt signaling and inhibited NPC cell migration and invasion, but promoted NPC cell apoptosis. +other 34626779 hsa-mir-15a Diabetic Retinopathy CONCLUSIONS: LBP attenuates diabetic retinal angiogenesis by rescuing the expression of miR-15a-5p in RF/6A cells. +circulation_biomarker_diagnosis_up 34626767 hsa-mir-451a Hepatitis B CONCLUSIONS: A plasma panel, including miR +circulation_biomarker_diagnosis_up 34626767 hsa-mir-340 Hepatitis B ROC curve analysis indicated that both plasma miR-451a and miR +genetics_overexpression_suppress 34626694 hsa-mir-34a Distal arthrogryposis type 2B Hsa-miR-34a-5p expression was directly correlated with BUP treatment and LINC00665 overexpression in SH-SY5Y cells. +genetics_GWAS 34626694 hsa-mir-34a Neurotoxicity Syndromes CONCLUSIONS: BUP-induced neurotoxicity in human neural cells may be regulated by the epigenetic axis of LINC00665 / hsa-miR-34a-5p. +genetics_GWAS 34626694 hsa-mir-132 Distal arthrogryposis type 2B Co-regulation of LINC00665 / hsa-miR3p epigenetic axis was further examined on BUP-induced apoptosis in SH-SY5Y cells. +lncRNA target 34626691 hsa-mir-1184 Carcinoma, Renal Cell "circSNX6 acts as a molecular ""sponge"" to relieve the suppressive effect of microRNA (miR)-1184 on its target gene, glycerophosphocholine phosphodiesterase 1 (GPCPD1), which increases intracellular lysophosphatidic acid (LPA) levels and, ultimately, promotes sunitinib resistance in RCC cells. Our findings demonstrated that the circSNX6/miR-1184/GPCPD1 axis had a critical role in regulation of intracellular LPA levels and sunitinib resistance in RCC; they also provide a novel prognostic indicator and promising therapeutic targets." +other 34626053 hsa-mir-21 Breast Neoplasms Among seven candidates, four miRNAs (miR-9, miR-16, miR-21, and miR-429) from the EV were highly elevated in early-stage breast cancer patients compared with healthy donors. +other 34626053 hsa-mir-9 Breast Neoplasms Among seven candidates, four miRNAs (miR-9, miR-16, miR-21, and miR-429) from the EV were highly elevated in early-stage breast cancer patients compared with healthy donors. +other 34626053 hsa-mir-429 Breast Neoplasms Among seven candidates, four miRNAs (miR-9, miR-16, miR-21, and miR-429) from the EV were highly elevated in early-stage breast cancer patients compared with healthy donors. +other 34626053 hsa-mir-16 Breast Neoplasms Among seven candidates, four miRNAs (miR-9, miR-16, miR-21, and miR-429) from the EV were highly elevated in early-stage breast cancer patients compared with healthy donors. +other 34625951 hsa-mir-1 Erythema miRNA-31 and miRNA-23b may play a role in PIH pathogenesis, although further validation is required. +other 34625951 hsa-mir-1 Hyperpigmentation miRNA-31 and miRNA-23b may play a role in PIH pathogenesis, although further validation is required. +other 34625951 hsa-mir-23b Erythema miRNA-31 and miRNA-23b may play a role in PIH pathogenesis, although further validation is required. +other 34625951 hsa-mir-23b Hyperpigmentation miRNA-31 and miRNA-23b may play a role in PIH pathogenesis, although further validation is required. +circulation_biomarker_diagnosis_up 34625660 hsa-mir-200c Severe Acute Respiratory Syndrome Taken together, our novel results identify that upregulation of miR-200c may increase the susceptibility of individuals with obesity to COVID-19. Considering miRNA are the earliest molecular regulators, the level of circulating miR-200c could be a potential biomarker in the early identification of those at the risk of severe COVID-19. +circulation_biomarker_diagnosis_up 34625660 hsa-mir-200c Obesity Taken together, our novel results identify that upregulation of miR-200c may increase the susceptibility of individuals with obesity to COVID-19. Considering miRNA are the earliest molecular regulators, the level of circulating miR-200c could be a potential biomarker in the early identification of those at the risk of severe COVID-19. +genetics_GWAS 34625583 hsa-mir-137 Hepatitis B, Chronic We revealed the dysregulated expression levels of GAS5 and miR-137 linked to their functioning SNPs were associated with CHBV risk and might act as potential therapeutic targets. +transcription factor target 34624808 hsa-mir-125b Lung Neoplasms Xenograft tumor models were constructed to explore the inhibitory effect of CoB1 and the role of miRNA-125b as a suppressor in lung cancer in vivo. +genetics_knock down_suppress 34624276 hsa-mir-212 Triple Negative Breast Neoplasms AKT3 overexpression reversed the inhibitory effect of miR +circulation_biomarker_diagnosis_up 34624208 hsa-mir-2392 COVID-19 We demonstrate that miR-2392 is present in the blood and urine of patients positive for COVID-19 but is not present in patients negative for COVID-19. +lncRNA target 34623609 hsa-mir-20 Norrie disease CONCLUSIONS: Our findings suggest that TTC28-AS1 attenuates HG-induced damage in HK-2 cells at least partially by targeting the miR-320a/CD2AP axis, highlighting its role as a promising therapeutic approach for DN treatment. +lncRNA target 34623609 hsa-mir-20a Norrie disease CONCLUSIONS: Our findings suggest that TTC28-AS1 attenuates HG-induced damage in HK-2 cells at least partially by targeting the miR-320a/CD2AP axis, highlighting its role as a promising therapeutic approach for DN treatment. +exosome 34623606 hsa-mir-29 Spinal Cord Injuries In all, exosomes derived from TCTN2-modified MSCs could improve functional recovery of SCI in vivo and attenuate LPS-induced neuronal apoptosis, inflammation, and oxidative stress in vitro via miR3p/IGF1R axis, suggesting a novel insight into the development of MSC-exosomes-based therapy for SCI. +genetics_GWAS 34623601 hsa-mir-34a Colorectal Neoplasms c-MYC overexpression abrogated EV-derived miR-34a-5p upregulation-induced effects on CRC. +other 34623553 hsa-mir-133b Pre-Eclampsia We found that miR-133b was up-regulated, with decreases in JAK2 and p-STAT3/STAT3 in placental tissues of PE patients. +genetics_overexpression_promote 34623217 hsa-mir-122 Carcinoma, Hepatocellular Cyclin G1 mRNA and protein level were suppressed in HepG2 tumors overexpression miR-122. +lncRNA target 34622398 hsa-mir-5128 Megalencephalic leukoencephalopathy with subcortical cysts PURPOSE: Due to the complexity of cytokine and microRNA function in progression and/or suppression of an infection, in this study, we examined miR-3473f, miR-2128, miR +lncRNA target 34622398 hsa-mir-7093 Megalencephalic leukoencephalopathy with subcortical cysts PURPOSE: Due to the complexity of cytokine and microRNA function in progression and/or suppression of an infection, in this study, we examined miR-3473f, miR-2128, miR +lncRNA target 34622398 hsa-mir-3473f Megalencephalic leukoencephalopathy with subcortical cysts PURPOSE: Due to the complexity of cytokine and microRNA function in progression and/or suppression of an infection, in this study, we examined miR-3473f, miR-2128, miR +lncRNA target 34622398 hsa-mir-6994 Megalencephalic leukoencephalopathy with subcortical cysts PURPOSE: Due to the complexity of cytokine and microRNA function in progression and/or suppression of an infection, in this study, we examined miR-3473f, miR-2128, miR +lncRNA target 34622398 hsa-mir-574 Megalencephalic leukoencephalopathy with subcortical cysts PURPOSE: Due to the complexity of cytokine and microRNA function in progression and/or suppression of an infection, in this study, we examined miR-3473f, miR-2128, miR +lncRNA target 34622398 hsa-mir-3473 Megalencephalic leukoencephalopathy with subcortical cysts PURPOSE: Due to the complexity of cytokine and microRNA function in progression and/or suppression of an infection, in this study, we examined miR-3473f, miR-2128, miR +lncRNA target 34622398 hsa-mir-7235 Megalencephalic leukoencephalopathy with subcortical cysts PURPOSE: Due to the complexity of cytokine and microRNA function in progression and/or suppression of an infection, in this study, we examined miR-3473f, miR-2128, miR +lncRNA target 34622398 hsa-mir-2128 Megalencephalic leukoencephalopathy with subcortical cysts PURPOSE: Due to the complexity of cytokine and microRNA function in progression and/or suppression of an infection, in this study, we examined miR-3473f, miR-2128, miR +transcription factor target 34621733 hsa-mir-27a Osteoporosis Additional experiments showed that miR-27a-5p suppressed autophagy that was activated in OVX rats. +lncRNA target 34621682 hsa-mir-525 Chordoma 5p could be promising therapeutic targets for the treatment of chordoma. +genetics_overexpression_promote 34621503 hsa-mir-34a Keratosis Follicularis Spinulosa Decalvans, X-Linked miR-34a can negatively regulate the expression of SATB1, and overexpression of SATB1 reverses the effects of overexpression of miR-34a on the proliferation, migration, and invasion of KFB. +lncRNA target 34621503 hsa-mir-34a Keloid OBJECTIVES: To explore the effect and mechanism of miR-34a on the proliferation, migration, and invasion of keloid fibroblasts (KFB). CONCLUSIONS: miR-34a inhibits the proliferation, migration, and invasion of keloid fibroblasts by downregulating the expression of SATB1. +lncRNA target 34621314 hsa-mir-16 Osteosarcoma CONCLUSION: LINC00662 exerts oncogenic functions in OS by targeting the miR +target gene 34621297 hsa-mir-1287 Carcinoma, Non-Small-Cell Lung CircDTL acts as an oncogene and exerts its effects via the miR-1287-5p/GPX4 axis in NSCLC +other 34620745 hsa-mir-326 Breast Neoplasms In summary, this study demonstrated that SP1-activated PCAT6 promoted the malignant behaviors of breast cancer cells by regulating the miR-326/LRRC8E axis. +genetics_knock down_suppress 34620742 hsa-mir-548c Carcinoma, Hepatocellular 5p, anti-miR-548c-3p or UBE2T overexpression restored the inhibitory effect of circ_0090049 knockdown on HCC cells. +genetics_knock down_suppress 34620742 hsa-mir-605 Carcinoma, Hepatocellular 5p, anti-miR-548c-3p or UBE2T overexpression restored the inhibitory effect of circ_0090049 knockdown on HCC cells. +exosome 34620741 hsa-mir-1253 Carcinoma, Non-Small-Cell Lung Exosomal circ_0007385 promoted NSCLC cell proliferation and stemness by regulating miR-1253/FAM83A axis. +genetics_knock down_promote 34620126 hsa-mir-216a Squamous Cell Carcinoma of Head and Neck Besides, miR-216a-5p or BCL2L2 knockdown partly attenuated the inhibitory influences of circ_0011946 silence or miR-216a-5p overexpression on OSCC cell progression. +other 34619990 hsa-mir-501 Leukoencephalopathies 3p and miR-1959 were the only miRNAs upregulated by OGD, and downregulated by OGD plus CX-4945 and MS-275. +other 34619990 hsa-mir-1959 Leukoencephalopathies 3p and miR-1959 were the only miRNAs upregulated by OGD, and downregulated by OGD plus CX-4945 and MS-275. +genetics_knock down_promote 34619576 hsa-mir-326 Breast Neoplasms miR-326 inhibition abolished the effects of hsa_circ_0000517 knockdown on the malignant behaviors of breast cancer cells. +lncRNA target 34619168 hsa-mir-195 Carcinoma, Non-Small-Cell Lung In conclusion, our research identified the regulation of CASC9/miR5p/FOXO3 feedback loop on NSCLC gefitinib resistance, which might help researchers develop potential therapeutic targets for NSCLC. +other 34619102 hsa-mir-26a Sepsis We aimed to explore the role of long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) sponging microRNA-26a-5p in sepsis-induced myocardial injury by regulating regulator of calcineurin 2 (Rcan2). +other 34619102 hsa-mir-26a Cardiomyopathies We aimed to explore the role of long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) sponging microRNA-26a-5p in sepsis-induced myocardial injury by regulating regulator of calcineurin 2 (Rcan2). +other 34618998 hsa-mir-491 Diabetes Mellitus, Type 2 5p expression could improve osteogenic differentiation of jawbone mesenchymal stem cells in patients with type 2 diabetes. +other 34618022 hsa-mir-370 Stomach Neoplasms 3p/EGFR axis. +genetics_overexpression_suppress 34617877 hsa-mir-145 Osteoporosis 5p was overexpressed in OP patients. +circRNA target 34617876 hsa-mir-196a Leukemia, Myeloid, Acute Furthermore, circCRKL inhibited AML cell proliferation via the miR-196a-5p/miR-196b-5p/p27 axis, suggesting a potential new target for AML therapy. +circRNA target 34617876 hsa-mir-196b Leukemia, Myeloid, Acute Furthermore, circCRKL inhibited AML cell proliferation via the miR-196a-5p/miR-196b-5p/p27 axis, suggesting a potential new target for AML therapy. +lncRNA target 34617873 hsa-mir-21 Hypoxia 5p expression, inhibits the TLR4/NF-kappaB signaling pathway and suppresses the apoptosis of type II alveolar epithelial cells during hypoxia/reoxygenation injury. +other 34617722 hsa-mir-134 Glioma Additionally, miR5p levels were significantly reduced and inversely related to ATF5 mRNA under HCMV infection. +other 34617063 hsa-mir-145 Popliteal Artery Aneurysm MiR-145 were significantly altered (1.7-fold) in those with isolated PA and AAA, whereas miR-326 were altered in those with bilateral (2.3-fold) and isolated PA (1.9-fold). +target gene 34616917 hsa-mir-4766 Colorectal Neoplasms circ_0000467 promotes the proliferation, metastasis, and angiogenesis in colorectal cancer cells through regulating KLF12 expression by sponging miR-4766-5p. +circulation_biomarker_diagnosis_up 34616615 hsa-mir-21 Breast Neoplasms CONCLUSION: This study's results showed that plasma exosomal hsa-miR +lncRNA target 34616613 hsa-mir-662 Melanoma Four groups of ceRNA interaction triplets were finally obtained, which miR-3662 might has potential implication for the treatment of metaststic melanoma patients, and futher experiments confirmed the regulating relationship and phenotype of this assumption. This study provides new targets to regulate metastatic process, predict metastatic potential and indicates that the miR-3662 can be used in the treatment of melanoma. +genetics_overexpression_promote 34616611 hsa-mir-1293 Adenocarcinoma of Lung Overexpression of PGM5 abrogated the effects of miR-1293 on the malignant phenotypes of LUAD cells. +other 34616498 hsa-mir-361 Carcinoma, Hepatocellular Overall, BAIAP2-AS1 modulated the miR3p/SOX4 axis to promote the development of HCC. +lncRNA target 34616424 hsa-mir-205 Lung Neoplasms 3p/c-Met axis, which may be a potential target for LC treatment. +other 34616299 hsa-mir-27a Osteoarthritis Collectively, XH exhibited protective effects against mechanical stimulation-induced ECM degradation by mediating the GAS5/miR-27a signaling pathway in OA chondrocytes. +other 34616173 hsa-mir-7 Colorectal Neoplasms 3p might be a marker of better outcomes. +other 34616173 hsa-mir-10a Colorectal Neoplasms 3p might be a marker of better outcomes. +other 34616173 hsa-mir-143 Colorectal Neoplasms 3p might be a marker of better outcomes. +circulation_biomarker_diagnosis_ns 34616172 hsa-mir-21 Osteosarcoma CONCLUSION: Serum and tumor tissue miR-21 expression levels in patients with OS are closely related to the effects of chemotherapy, making miR-21 a potential biomarker and therapeutic target for the diagnosis and evaluation of chemotherapy effects on patients with OS. +other 34616170 hsa-mir-23a Lichen Planus, Oral MiR-23a-3p was at the low expression in OLP patients and showed close association with the disease severity. +genetics_knock down_promote 34616159 hsa-mir-98 Asthma CONCLUSION: Our work disclosed that knockdown of circERBB2 suppressed PDGF-BB-caused proliferation, migration and inflammatory response of ASMCs, through regulating miR5p/IGF1R signaling, presented circERBB2 as a promising therapeutic target for asthma. +other 34615552 hsa-mir-183 Follicular Atresia CONCLUSIONS: We provide a comprehensive perspective of lncRNA regulation of follicular atresia, and demonstrate that NORHA, a novel lncRNA related to follicular atresia, induces GC apoptosis by influencing the activities of the miR96-182 cluster and FoxO1 axis. +genetics_GWAS 34615546 hsa-mir-152 Leukemia CONCLUSIONS: Taken together, our findings identify two oncogenic regulatory axes in NPM1-mutated AML centered on HOTAIRM1: one involving EGR1 and MDM2 in the nucleus and the other involving the miR3p/ULK3 axis in the cytoplasm. +exosome 34614416 hsa-mir-182 Triple Negative Breast Neoplasms loaded HUCMSC-exosomes can suppress TNBC invasion, suggesting that exosomes containing miR-3182 could be a reliable therapeutic paradigm in TNBC therapy. +transcription factor target 34614259 hsa-mir-125b Squamous Cell Carcinoma of Head and Neck CONCLUSION: EZH2 inhibits erastin-induced ferroptosis in TSCC cells via miR-125b-5p/SLC7A11 axis. +lncRNA target 34613933 hsa-mir-1271 Prostatic Neoplasms, Castration-Resistant In summary, Qi Ling inhibited docetaxel resistance and glycolysis of CRPC possibly via SNHG10/miR5p/TRIM66 pathway. +genetics_knock down_promote 34612783 hsa-mir-545 Squamous Cell Carcinoma of Head and Neck After performing a series of cell functional experiments, it was found that knockdown of lncRNA CASC9 or LAMC2 resulted in the inhibition of proliferation, colony formation, and migration of OSCC cells, but their negative effects could be partly impaired by the miR +lncRNA target 34612550 hsa-mir-214 Nasopharyngeal Carcinoma CONCLUSIONS: The present study demonstrated that circ-ITCH suppressed NPC tumorigenesis by upregulating PTEN expression through interacting with miR-214, thus proposing a novel mechanism for NPC inhibition. +lncRNA target 34612153 hsa-mir-654 Carcinoma, Hepatocellular In conclusion, LINC00460 aggravated cell stemness in HCC via targeting miR +lncRNA target 34612153 hsa-mir-503 Carcinoma, Hepatocellular In conclusion, LINC00460 aggravated cell stemness in HCC via targeting miR +lncRNA target 34612147 hsa-let-7b Ovarian Neoplasms The downregulation of DDX19A reversed the inhibitory effects of MB-let-7b-5p inhibitor on OVCA cells. +lncRNA target 34612146 hsa-mir-146a Neuralgia Finally, we demonstrated that CRNDE contributed to the progression of CCI-induced NP via competitive binding to miR-146a-5p to upregulate WNT5A. +genetics_knock down_suppress 34612138 hsa-mir-4306 Carcinoma, Hepatocellular Finally, miR-4306 downregulation or KDM2A overexpression reversed the prohibitive role of UNC5B-AS1 knockdown in HCC progression. +circulation_biomarker_prognosis_ns 34612058 hsa-mir-19b Heart Failure, Acute Conclusions Circulating miR-19b-3p could be a valuable prognostic biomarker for AHF. In addition, a high level of circulating miR-19b-3p might indicate ventricular hypertrophy in AHF subjects. +other 34611549 hsa-mir-92a Stomach Neoplasms miR-92a could also be used as a valuable indicator for predicting the prognosis of gastric cancer patients. +other 34611404 hsa-mir-607 Ischemic Stroke We used bioinformatics approaches to investigate a functional ANGPT1 variant that interferes with miR-607 and explored its association with IS. +lncRNA target 34611295 hsa-mir-210 Fetal Growth Retardation 3p expression with maternal, placental and newborn parameters and with placental expression of their potential target genes PTEN, VEGF, FLT and ENG in a set of well-characterized small- (SGA) and appropriate- (AGA) for gestational age full-term singleton pregnancies. +lncRNA target 34611295 hsa-mir-141 Fetal Growth Retardation 3p expression with maternal, placental and newborn parameters and with placental expression of their potential target genes PTEN, VEGF, FLT and ENG in a set of well-characterized small- (SGA) and appropriate- (AGA) for gestational age full-term singleton pregnancies. +lncRNA target 34611295 hsa-mir-21 SHORT syndrome 3p expression with maternal, placental and newborn parameters and with placental expression of their potential target genes PTEN, VEGF, FLT and ENG in a set of well-characterized small- (SGA) and appropriate- (AGA) for gestational age full-term singleton pregnancies. +lncRNA target 34611295 hsa-mir-210 SHORT syndrome 3p expression with maternal, placental and newborn parameters and with placental expression of their potential target genes PTEN, VEGF, FLT and ENG in a set of well-characterized small- (SGA) and appropriate- (AGA) for gestational age full-term singleton pregnancies. +lncRNA target 34611295 hsa-mir-141 SHORT syndrome 3p expression with maternal, placental and newborn parameters and with placental expression of their potential target genes PTEN, VEGF, FLT and ENG in a set of well-characterized small- (SGA) and appropriate- (AGA) for gestational age full-term singleton pregnancies. +lncRNA target 34611295 hsa-mir-21 Fetal Growth Retardation 3p expression with maternal, placental and newborn parameters and with placental expression of their potential target genes PTEN, VEGF, FLT and ENG in a set of well-characterized small- (SGA) and appropriate- (AGA) for gestational age full-term singleton pregnancies. +circRNA target 34611229 hsa-mir-183 Intracranial Aneurysm 3p was remarkably suppressed in the endothelial cells collected from RIAs patients when compared with UIAs patients. +circRNA target 34611229 hsa-mir-877 Intracranial Aneurysm 3p was remarkably suppressed in the endothelial cells collected from RIAs patients when compared with UIAs patients. +exosome 34611143 hsa-mir-370 Stomach Neoplasms A series of experiments were performed to confirm that circUBE2Q2 regulates GC progression via the circUBE2Q2-miR3p-STAT3 axis and promotes tumor metastasis through exosomal communication. +lncRNA target 34611140 hsa-mir-342 Leukemia, Myelogenous, Chronic, BCR-ABL Positive 5p was downregulated in CML patients and had a significant inhibitory effect on cell proliferation in CML. +lncRNA target 34610759 hsa-mir-101 Neonatal Sepsis 3p facilitated the inflammation in NS by targeting DUSP1. +genetics_knock down_promote 34610715 hsa-mir-21 Prostatic Hyperplasia 3p intensified BPH and inflammation level, while knockdown of miR +lncRNA target 34610483 hsa-mir-146b Cholangiocarcinoma CONCLUSION: MiR-146b-5p is a cholangiocarcinoma suppressor by inhibiting cell proliferation and promoting cell apoptosis with targeting TRAF6, possibly via modulating p53 translocation to mitochondria. +genetics_overexpression_promote 34610416 hsa-mir-21 Glioma Conversely, miR-21 overexpression increased cell proliferation and migration; as well as the levels of IRS1, SREBP-1, FASN, and ACC in human PCa cells. +genetics_overexpression_promote 34610416 hsa-mir-21 Prostatic Neoplasms Conversely, miR-21 overexpression increased cell proliferation and migration; as well as the levels of IRS1, SREBP-1, FASN, and ACC in human PCa cells. +other 34610317 hsa-mir-29c Lymphopenia However, after damage, when profound thymocyte depletion occurs, this TAM-Rac1-NOD2-miR29c pathway is attenuated, increasing production of IL-23 and BMP4. +other 34610219 hsa-mir-17 Carcinoma, Non-Small-Cell Lung 5p/PD-L1. +other 34609952 hsa-mir-130 Neuralgia Up-regulating miR5p repressed LPS-induced inflammation in astrocytes. +genetics_overexpression_suppress 34609952 hsa-mir-130a Neuralgia The profiles of MEG3, microRNA (miR)-130a-5p, CXC motif chemokine receptor 12 (CXCL12)/CXC motif chemokine receptor 4 (CXCR4), and the Rac1/NF-kappaB pathway in CCI rats' spinal cord tissues and astrocytes were monitored by reverse transcription-quantitative PCR (RT-qPCR) and western blot (WB). RESULTS: MEG3, CXCL12 and CXCR4 were overexpressed and miR-130a-5p was knocked down in CCI rats and LPS-induced astrocytes. +circulation_biomarker_diagnosis_up 34609722 hsa-mir-624 Congenital Hypothyroidism 5p inhibitor signally enhanced fT4 levels and reduced TSH levels in the plasma of CH rats, and improved CH rat depressive behaviors by targeting SIRT1. +other 34609560 hsa-mir-29b-1 Osteitis Deformans Six mature miRs, miR-29b1-3p, miR-15b-5p, miR-181a-5p, let-7i-3p, miR-500b-5p, and miR-1246, were found to be significantly decreased in pagetic overactive osteoclasts. +other 34609560 hsa-mir-1246 Osteitis Deformans Six mature miRs, miR-29b1-3p, miR-15b-5p, miR-181a-5p, let-7i-3p, miR-500b-5p, and miR-1246, were found to be significantly decreased in pagetic overactive osteoclasts. +other 34609560 hsa-mir-181a Osteitis Deformans Six mature miRs, miR-29b1-3p, miR-15b-5p, miR-181a-5p, let-7i-3p, miR-500b-5p, and miR-1246, were found to be significantly decreased in pagetic overactive osteoclasts. +other 34609560 hsa-mir-15b Osteitis Deformans Six mature miRs, miR-29b1-3p, miR-15b-5p, miR-181a-5p, let-7i-3p, miR-500b-5p, and miR-1246, were found to be significantly decreased in pagetic overactive osteoclasts. +other 34609560 hsa-let-7i Osteitis Deformans Six mature miRs, miR-29b1-3p, miR-15b-5p, miR-181a-5p, let-7i-3p, miR-500b-5p, and miR-1246, were found to be significantly decreased in pagetic overactive osteoclasts. +transcription factor target 34609285 hsa-mir-29a Epilepsy, Temporal Lobe MiR-29a may be involved in the pathogenesis of TLE through regulation of neuronal apoptosis and neuroinflammation via targeting HMGB1. +other 34609116 hsa-mir-146a Diabetes Mellitus, Type 2 Expression of cytokine IL-6, IL-10, miR-146a are found to cause diabetic neuropathy. +exosome 34609045 hsa-mir-22 Spinal Cord Injuries loaded MSCs-EV (EV-miRNA-22) could cooperate with EV to inhibit inflammatory response and nerve function repair after SCI. +other 34609043 hsa-mir-150 Diabetic Cardiomyopathies 5p and downregulate CCND2 to promote cardiomyocyte ferroptosis and DbCM development. +other 34608897 hsa-mir-205 Chronic Rhinosinusitis With Nasal Polyps CONCLUSIONS: miRNA 205-5p was increased in CRSwNP compared to controls, and it was especially expressed in CRSwNP patients with higher T2 inflammation (measured by both IL-5 levels and local eosinophilia) and worst clinical presentation. +other 34608841 hsa-mir-589 Hyperglycemia Mechanistically, circ-UBAP2 sponges miR5p, which is downregulated under hyperglycemic conditions. +genetics_knock down_suppress 34608841 hsa-mir-589 Duane Retraction Syndrome Taken together, knockdown of circ-UBAP2 relieved HG-induced oxidative stress and dysfunctions of the hRMECs through the miR5p/EGR1 axis, which may offer a promising therapeutic target for DR. +lncRNA target 34608826 hsa-mir-652 Carcinoma, Hepatocellular 3p mimic or inhibitor. +other 34608813 hsa-mir-138 Adenocarcinoma of Lung 5p-HIF1A axis. +lncRNA target 34608568 hsa-mir-23a Diabetic Nephropathies Thus, we conclude that miR-23a-3p attenuates the development of DKD through Egr1, suggesting that targeting miR-23a-3p may be a novel therapeutic approach for DKD. +lncRNA target 34608273 hsa-mir-20a Corneal dystrophy, epithelial basement membrane Mechanistically, THAP7-AS1 interacted with the 1-50 Amino Acid Region (nuclear localization signal) of CUL4B through its 1-442 nt Sequence, and it promoted interaction between nuclear localization signal (NLS) and importin alpha1, and improved the CUL4B protein entry into the nucleus, repressing miR3p and miR-320a expression by CUL4B-catalyzed H2AK119ub1 and the EZH2-mediated H3K27me3, subsequently activating PI3K/AKT signaling pathway to promote GC progression. +lncRNA target 34608273 hsa-mir-22 Corneal dystrophy, epithelial basement membrane Mechanistically, THAP7-AS1 interacted with the 1-50 Amino Acid Region (nuclear localization signal) of CUL4B through its 1-442 nt Sequence, and it promoted interaction between nuclear localization signal (NLS) and importin alpha1, and improved the CUL4B protein entry into the nucleus, repressing miR3p and miR-320a expression by CUL4B-catalyzed H2AK119ub1 and the EZH2-mediated H3K27me3, subsequently activating PI3K/AKT signaling pathway to promote GC progression. +other 34608109 hsa-mir-203a Wilms Tumor CONCLUSIONS We conclude that a downregulation of miR-184, miR5p, and miR-203a expression is observed in both regressive and blastemal tumors, but larger-scale studies are needed to confirm whether the degree of their underexpression correlates with the number of blastemal elements in a sample. +other 34608109 hsa-mir-184 Wilms Tumor CONCLUSIONS We conclude that a downregulation of miR-184, miR5p, and miR-203a expression is observed in both regressive and blastemal tumors, but larger-scale studies are needed to confirm whether the degree of their underexpression correlates with the number of blastemal elements in a sample. +other 34608109 hsa-mir-194 Wilms Tumor CONCLUSIONS We conclude that a downregulation of miR-184, miR5p, and miR-203a expression is observed in both regressive and blastemal tumors, but larger-scale studies are needed to confirm whether the degree of their underexpression correlates with the number of blastemal elements in a sample. +other 34607711 hsa-mir-223 endometrial serous adenocarcinoma Of these, increased miR-223 expression (>median) was associated with worse OS (p = 0.0496) in an independent dataset (TCGA dataset) comprising of 140 patients with USC (mixed or pure serous). Upregulation of miR-223 may be a prognostic factor in USC. +genetics_GWAS 34607594 hsa-mir-219a-1 Schizophrenia METHODS: In a case-control study, five SNPs located in 6p21.3-p23.1 including rs2021722 in human leukocyte antigen (HLA) locus and rs107822, rs383711, rs439205 and rs421446 within the upstream of microRNA-219a-1 were genotyped in 454 schizophrenia patients and 445 healthy controls to investigate the possible association between the loci and schizophrenia in a Han Chinese population. +lncRNA target 34607540 hsa-mir-141 Osteosarcoma 3p has been reported to act as a tumor suppressor in osteosarcoma. +circRNA target 34607506 hsa-mir-485 Stomach Neoplasms 5p-GSK3A regulatory network inhibited GC cell proliferation, migration, and invasion, suggesting that circ-HN1 is a potential target for GC therapy. +lncRNA target 34607195 hsa-mir-21 Ischemic Stroke OBJECTIVE: Long non-coding RNA maternally expressed gene 3 (lnc-MEG3) directly targets microRNA-21 (miR-21) to regulate the vascular microenvironment, and is closely implicated in the pathology of acute ischemic stroke (AIS). +other 34607003 hsa-mir-106a Lung Neoplasms We examined regulatory functions of miR-106a-5p in DDP-resistant lung cancer cells. +lncRNA target 34606982 hsa-mir-431 Liver Neoplasms CONCLUSION: Circ_0078710 promotes the progression of liver cancer by regulating TXNDC5 expression by targeting miR +other 34606735 hsa-mir-1 Myocardial Infarction The results suggested that miR-1/Myocd induction combined with encapsulation of transduced cells in CS/CO hydrogel increased efficiency of MSCs differentiation into iCMs and could improve heart function in MI model of rats after implantation. +lncRNA target 34606648 hsa-mir-206 Carcinoma, Hepatocellular Disrupting the interaction between miR-206 and Kras offset the roles of miR-206 in inhibiting immunosuppression and HCC. +lncRNA target 34606644 hsa-mir-146 Gout based therapy effectively inhibited the formation of NETs in rats with gout. +lncRNA target 34606420 hsa-mir-199a Endometrial Neoplasms Additionally, miR-199a-3p inhibitor partly relieved the effects of silencing TTN-AS1 and RUNX1 in OSCC cells due to their targeting relationship. +lncRNA target 34606414 hsa-mir-411 Glioblastoma miR-411 suppressed the growth, migration, and invasion of glioblastoma cells via modulating signal transducer and activator of transcription 3 (STAT3). +circulation_biomarker_diagnosis_up 34606407 hsa-mir-637 Carotid Stenosis Kaplan-Meier survival and Cox regression were used to evaluate the potential predictive ability of serum miR-637 levels during follow-up for cerebral ischemia events. +circulation_biomarker_diagnosis_up 34606407 hsa-mir-637 Brain Ischemia Kaplan-Meier survival and Cox regression were used to evaluate the potential predictive ability of serum miR-637 levels during follow-up for cerebral ischemia events. +lncRNA target 34606403 hsa-mir-214 Pre-Eclampsia CONCLUSIONS: Up-regulated SNHG7 protects against PE through modulating the miR +lncRNA target 34605515 hsa-mir-141 Prostatic Neoplasms The microRNA-141 (miR-141), a potential biomarker in prostate cancer, was employed as a model target in the microcapsular biosensor. +lncRNA target 34605350 hsa-mir-196b Esophageal Squamous Cell Carcinoma Besides, the suppressor of cytokine signaling 2 (SOCS2) is the target of miR-196b in ESCC. +genetics_knock down_suppress 34605348 hsa-mir-493 Stomach Neoplasms 5p was a target of circPRKDC, and the repressive impact of circPRKDC knockdown on GC development was neutralized by miR +genetics_knock down_promote 34605103 hsa-mir-497 Osteosarcoma 5p overexpression obviously restrained OS proliferation, invasion, and migration. +circulation_biomarker_diagnosis_up 34604414 hsa-mir-21 Stomach Neoplasms In addition, the miRNA RT-qPCR results showed that, the expression level of miR-21 was significantly higher in gastritis group compared to the healthy group (p< 0.05). CONCLUSION: the present study clearly demonstrated the increasing level of blood miR-21 among the gastritis patients infected by H. +other 34604408 hsa-mir-208a Cardiovascular Diseases Also, a significant increase in the expression of miR-208 (HF> arrhythmia> ACS> MI) and a significant decrease in the expression of miR-1 (ACS> arrhythmia> HF> MI) were found in all four groups in cardiovascular patients. CONCLUSION: The results showed increases in oxidative stress, inflammation, apoptotic factors, and in the expression of miR-208a in a variety of cardiovascular patients (ACS, MI, arrhythmia, and HF). +other 34604408 hsa-mir-208 Cardiovascular Diseases Also, a significant increase in the expression of miR-208 (HF> arrhythmia> ACS> MI) and a significant decrease in the expression of miR-1 (ACS> arrhythmia> HF> MI) were found in all four groups in cardiovascular patients. CONCLUSION: The results showed increases in oxidative stress, inflammation, apoptotic factors, and in the expression of miR-208a in a variety of cardiovascular patients (ACS, MI, arrhythmia, and HF). +transcription factor target 34604236 hsa-mir-100 gastric adenocarcinoma In this study, hsa-miR5p was identified as the only dysregulated miRNA in STAD samples through an analysis of three miRNA expression matrices. +target gene 34604211 hsa-mir-98 Carcinoma, Non-Small-Cell Lung Circular RNA 0006349 Augments Glycolysis and Malignance of Non-small Cell Lung Cancer Cells Through the microRNA-98/MKP1 Axis. +genetics_overexpression_promote 34604205 hsa-mir-146a Pulmonary Disease, Chronic Obstructive The overexpression of MALAT1 could increase the expression of COX2 by inhibiting the expression of miR-146a, thus affecting the pulmonary function of COPD patients. +genetics_overexpression_suppress 34604093 hsa-mir-1224 Stomach Neoplasms Moreover, in vitro and in vivo assays revealed that the overexpression of miR-1224 inhibited cell proliferation, migration, and invasion in GC cells. +other 34604087 hsa-mir-21 Primary Central Nervous System Lymphoma MicroRNA-21 assays also seemed to be more accurate in the diagnosis of PCNSL. +target gene 34604044 hsa-mir-196a Stomach Neoplasms CircPTK2 Suppresses the Progression of Gastric Cancer by Targeting the MiR-196a-3p/AATK Axis. +circulation_biomarker_diagnosis_up 34603911 hsa-mir-22 Adenocarcinoma of Lung We further validated that LINC00968 localized in cytoplasm and acted as an upstream regulator of microRNA miR +other 34603671 hsa-mir-155 Lung Neoplasms This method can simultaneously quantify miR-155 and miR-21 in living cells and in lung cancer tissues, and it can distinguish the expression of miRNAs between non-small cell lung cancer patients and healthy persons. +other 34603671 hsa-mir-21 Lung Neoplasms This method can simultaneously quantify miR-155 and miR-21 in living cells and in lung cancer tissues, and it can distinguish the expression of miRNAs between non-small cell lung cancer patients and healthy persons. +lncRNA target 34603558 hsa-mir-1225 Glioma CONCLUSION: Our findings revealed the tumor-promotive roles of LINC00355 in the progression of glioma, indicating that LINC00355 exhibited ceRNA functions via modulating miR-1225/FNDC3B axis. +other 34603557 hsa-mir-375 Thyroid Cancer, Papillary METHODS: In this study, qRT-PCR was used to investigate the expression levels of the SOX15 gene and of miR-182, miR-183, miR-375, and miR-96 in thyroid tumors and adjacent noncancerous tissues. +other 34603557 hsa-mir-183 Thyroid Cancer, Papillary METHODS: In this study, qRT-PCR was used to investigate the expression levels of the SOX15 gene and of miR-182, miR-183, miR-375, and miR-96 in thyroid tumors and adjacent noncancerous tissues. +other 34603557 hsa-mir-96 Thyroid Cancer, Papillary METHODS: In this study, qRT-PCR was used to investigate the expression levels of the SOX15 gene and of miR-182, miR-183, miR-375, and miR-96 in thyroid tumors and adjacent noncancerous tissues. +other 34603557 hsa-mir-182 Thyroid Cancer, Papillary METHODS: In this study, qRT-PCR was used to investigate the expression levels of the SOX15 gene and of miR-182, miR-183, miR-375, and miR-96 in thyroid tumors and adjacent noncancerous tissues. +lncRNA target 34603528 hsa-mir-485 Arthritis, Rheumatoid RAFLSs were transfected with short interfering (si)-X-inactive specific transcript (XIST), microRNA (miR)-485 mimic, miR-485 inhibitor or si-PSMB8 or combination. +circulation_biomarker_diagnosis_ns 34603466 hsa-mir-127 Respiratory Distress Syndrome It suggests that the serum miR-127 level is an important indicator for evaluating the severity of ARDS patients. +transcription factor target 34603449 hsa-mir-491 Colonic Neoplasms According to these results, CS-Rh2-TPP is able to upregulate miR-491 in CCCs, thus suppressing the metastasis and growth of CC. +transcription factor target 34603448 hsa-mir-559 Colorectal Neoplasms miR-559 inhibited, while CBS accelerated, CRC proliferation. DiAcSpm accelerated CRC proliferation by regulating the miR-559/CBS axis. +other 34603374 hsa-mir-346 Tricuspid Valve Insufficiency 5p, and OPN4; INTS6-AS1, hsa-miR-4262, and NEURL1B; TTN-AS1, hsa-miR-376b-3p, and TRPM5; and DLX6-AS1, hsa-miR-346, and BIRC7 axes were obtained by constructing the ceRNA networks. +other 34603374 hsa-mir-653 Cardiomyopathy, Right Ventricular Dilated 5p, and OPN4; INTS6-AS1, hsa-miR-4262, and NEURL1B; TTN-AS1, hsa-miR-376b-3p, and TRPM5; and DLX6-AS1, hsa-miR-346, and BIRC7 axes were obtained by constructing the ceRNA networks. +other 34603374 hsa-mir-539 Cardiomyopathy, Right Ventricular Dilated 5p, and OPN4; INTS6-AS1, hsa-miR-4262, and NEURL1B; TTN-AS1, hsa-miR-376b-3p, and TRPM5; and DLX6-AS1, hsa-miR-346, and BIRC7 axes were obtained by constructing the ceRNA networks. +other 34603374 hsa-mir-346 Cardiomyopathy, Right Ventricular Dilated 5p, and OPN4; INTS6-AS1, hsa-miR-4262, and NEURL1B; TTN-AS1, hsa-miR-376b-3p, and TRPM5; and DLX6-AS1, hsa-miR-346, and BIRC7 axes were obtained by constructing the ceRNA networks. +other 34603374 hsa-mir-653 Tricuspid Valve Insufficiency 5p, and OPN4; INTS6-AS1, hsa-miR-4262, and NEURL1B; TTN-AS1, hsa-miR-376b-3p, and TRPM5; and DLX6-AS1, hsa-miR-346, and BIRC7 axes were obtained by constructing the ceRNA networks. +other 34603374 hsa-mir-376b Cardiomyopathy, Right Ventricular Dilated 5p, and OPN4; INTS6-AS1, hsa-miR-4262, and NEURL1B; TTN-AS1, hsa-miR-376b-3p, and TRPM5; and DLX6-AS1, hsa-miR-346, and BIRC7 axes were obtained by constructing the ceRNA networks. +other 34603374 hsa-mir-539 Tricuspid Valve Insufficiency 5p, and OPN4; INTS6-AS1, hsa-miR-4262, and NEURL1B; TTN-AS1, hsa-miR-376b-3p, and TRPM5; and DLX6-AS1, hsa-miR-346, and BIRC7 axes were obtained by constructing the ceRNA networks. +other 34603374 hsa-mir-497 Tricuspid Valve Insufficiency 5p, and OPN4; INTS6-AS1, hsa-miR-4262, and NEURL1B; TTN-AS1, hsa-miR-376b-3p, and TRPM5; and DLX6-AS1, hsa-miR-346, and BIRC7 axes were obtained by constructing the ceRNA networks. +other 34603374 hsa-mir-497 Cardiomyopathy, Right Ventricular Dilated 5p, and OPN4; INTS6-AS1, hsa-miR-4262, and NEURL1B; TTN-AS1, hsa-miR-376b-3p, and TRPM5; and DLX6-AS1, hsa-miR-346, and BIRC7 axes were obtained by constructing the ceRNA networks. +other 34603374 hsa-mir-4262 Cardiomyopathy, Right Ventricular Dilated 5p, and OPN4; INTS6-AS1, hsa-miR-4262, and NEURL1B; TTN-AS1, hsa-miR-376b-3p, and TRPM5; and DLX6-AS1, hsa-miR-346, and BIRC7 axes were obtained by constructing the ceRNA networks. +other 34603374 hsa-mir-4262 Tricuspid Valve Insufficiency 5p, and OPN4; INTS6-AS1, hsa-miR-4262, and NEURL1B; TTN-AS1, hsa-miR-376b-3p, and TRPM5; and DLX6-AS1, hsa-miR-346, and BIRC7 axes were obtained by constructing the ceRNA networks. +other 34603374 hsa-mir-376b Tricuspid Valve Insufficiency 5p, and OPN4; INTS6-AS1, hsa-miR-4262, and NEURL1B; TTN-AS1, hsa-miR-376b-3p, and TRPM5; and DLX6-AS1, hsa-miR-346, and BIRC7 axes were obtained by constructing the ceRNA networks. +other 34603024 hsa-mir-146a Lung Neoplasms Conclusion: Our research demonstrated the potential of using ANRIL rs1333049 (G > C) and miR-146A rs2910164 (C > G) as biomarkers to support the prediction of a better prognosis for lung cancer patients receiving platinum-based chemotherapy. +other 34602559 hsa-mir-122a Chemical and Drug Induced Liver Injury In order to reduce the Ad vector-induced hepatotoxicity, we previously developed an Ad vector containing the sequences perfectly complementary to a liver-specific microRNA (miRNA), miR-122a, in the 3'-untranslated region (UTR) of the E4 gene. +other 34602528 hsa-mir-146 Lung Diseases Thus, elevated miR-146a and miR-146b may have a relationship with pulmonary dysfunction after PM2.5 chronic exposure. +other 34602528 hsa-mir-146a Lung Diseases Thus, elevated miR-146a and miR-146b may have a relationship with pulmonary dysfunction after PM2.5 chronic exposure. +other 34602528 hsa-mir-146b Lung Diseases Thus, elevated miR-146a and miR-146b may have a relationship with pulmonary dysfunction after PM2.5 chronic exposure. +lncRNA target 34602449 hsa-mir-494 Premature Birth Understanding the role of miR3p in endometrial receptivity is of great significance for exploring new targets for the diagnosis and treatment of early pregnancy failure, and improving the success rates of artificial reproduction. +lncRNA target 34602415 hsa-mir-26a Carcinoma, Hepatocellular The obtained data introduce an evidence for the suppressive impact of miRNA-26a on liver tumor formation and its possible manipulation as a therapeutic design for HCC. +circulation_biomarker_diagnosis_ns 34602388 hsa-mir-126 Diabetic Nephropathies This study aims to investigate the effect of hyperbaric oxygen combined with alprostadil in the treatment of elderly diabetic nephropathy (DN) and its effect on serum miR-126 and miR-342 levels. The application of hyperbaric oxygen combined with alprostadil in the treatment of elderly DN patients can improve renal function, lower blood glucose, improve vascular endothelial function and immune function, adjust serum miR-126 and miR-342 levels, thereby increasing curative effect. +circulation_biomarker_diagnosis_ns 34602388 hsa-mir-342 Diabetic Nephropathies This study aims to investigate the effect of hyperbaric oxygen combined with alprostadil in the treatment of elderly diabetic nephropathy (DN) and its effect on serum miR-126 and miR-342 levels. The application of hyperbaric oxygen combined with alprostadil in the treatment of elderly DN patients can improve renal function, lower blood glucose, improve vascular endothelial function and immune function, adjust serum miR-126 and miR-342 levels, thereby increasing curative effect. +lncRNA target 34602057 hsa-mir-146b Inflammation CONCLUSIONS: MINCR may induce alveolar epithelial cell injury and inflammation and aggravate the progression of ALI/ARDS through miR-146b-5p and TRAF6/NF-kappaB pathways, which would provide a promising target for the treatment of ALI/ARDS. +lncRNA target 34602057 hsa-mir-146b Respiratory Distress Syndrome CONCLUSIONS: MINCR may induce alveolar epithelial cell injury and inflammation and aggravate the progression of ALI/ARDS through miR-146b-5p and TRAF6/NF-kappaB pathways, which would provide a promising target for the treatment of ALI/ARDS. +other 34601609 hsa-mir-130b Kidney Failure, Chronic CONCLUSIONS: Adipose miR-130b and miR5p expressions correlated with body composition parameters, frailty, and predicted cardiovascular events and mortality in advanced CKD patients. +other 34601609 hsa-mir-17 Kidney Failure, Chronic CONCLUSIONS: Adipose miR-130b and miR5p expressions correlated with body composition parameters, frailty, and predicted cardiovascular events and mortality in advanced CKD patients. +lncRNA target 34601499 hsa-mir-539 Colorectal Neoplasms Our data reveal the novel role of miR-539 in regulating ferroptosis in CRC via activation of the SAPK/JNK axis, providing new insight into the mechanism of abnormal proliferation in CRC and a novel potential therapeutic target for advanced CRC. +genetics_overexpression_promote 34601384 hsa-mir-146a Colorectal Neoplasms The present study aimed to investigate how exogenous induction of miR-146a affects CXCR4 gene and protein expression and also proliferation, apoptosis and migration of CRC cells. Therefore, our results are indicating that overexpression of miR-146a, despite downregulation of oncogenic CXCR4, may not lead to a universal tumor suppressive effect in all CRC cells, and this is possibly due to differences in miR-146a effects on signaling pathways in each cell type. +exosome 34601333 hsa-mir-27a Carcinoma, Hepatocellular CONCLUSION: M2 macrophages-derived exosomal miR-27a-3p promotes cancer stemness of HCC via downregulating TXNIP. +other 34600545 hsa-mir-10b Keloid Furthermore, nine core miRNAs (hsa-mir-124, hsa-let-7, hsa-mir-155, hsa-mir-26a, hsa-mir-941, hsa-mir-10b, hsa-mir-20, hsa-mir-31 and hsa-mir-372), and two core TFs (SP1 and TERT) were identified to play important roles in keloid formation. CONCLUSIONS: GNG13, ADCY8, NPY and HTR1A may act as core genes in keloid formation and these core genes establish relationship with SP1 and miRNA (hsa-mir-372, hsa-mir-20, hsa-mir-10b), which may influence multiple signaling pathways in the pathogenesis of keloid. +other 34600545 hsa-mir-372 Keloid Furthermore, nine core miRNAs (hsa-mir-124, hsa-let-7, hsa-mir-155, hsa-mir-26a, hsa-mir-941, hsa-mir-10b, hsa-mir-20, hsa-mir-31 and hsa-mir-372), and two core TFs (SP1 and TERT) were identified to play important roles in keloid formation. CONCLUSIONS: GNG13, ADCY8, NPY and HTR1A may act as core genes in keloid formation and these core genes establish relationship with SP1 and miRNA (hsa-mir-372, hsa-mir-20, hsa-mir-10b), which may influence multiple signaling pathways in the pathogenesis of keloid. +other 34600545 hsa-mir-20 Keloid Furthermore, nine core miRNAs (hsa-mir-124, hsa-let-7, hsa-mir-155, hsa-mir-26a, hsa-mir-941, hsa-mir-10b, hsa-mir-20, hsa-mir-31 and hsa-mir-372), and two core TFs (SP1 and TERT) were identified to play important roles in keloid formation. CONCLUSIONS: GNG13, ADCY8, NPY and HTR1A may act as core genes in keloid formation and these core genes establish relationship with SP1 and miRNA (hsa-mir-372, hsa-mir-20, hsa-mir-10b), which may influence multiple signaling pathways in the pathogenesis of keloid. +genetics_knock down_promote 34600394 hsa-mir-150 Glomerulonephritis, IGA The results showed that in the GH-IgAN group, the miRNA-150 expression was positively correlated with systolic blood pressure (beta=2.36, 95% CI 1.11-3.61, P=0.0016), diastolic blood pressure (beta=1.02, 95% CI 0.22-1.82, P=0.0224), uric acid (beta=7.43, 95% CI 1.81-13.04, P=0.0184), leukocyte count (beta=0.22, 95% CI 0.09-0.35, P=0039), neutrophil count (beta=0.19, 95% CI 0.06-0.32, P=0.0096), cholesterol (beta=0.09, 95% CI 0.02-0.16, P=0.0207) and triglyceride level (beta=0.16, 95% CI 0.10-0.22, P<0.000). +lncRNA target 34600339 hsa-mir-194 Brain Injuries Our study suggested MSC-EXs loaded with miR-194 attenuated OGD/R-induced injury via targeting Bach1, providing a new therapeutic strategy for cerebral injuries. +other 34600339 hsa-mir-194 Vascular Diseases The neuroprotective function of miR-194 on neurovascular endothelial cell injury is perceived as a novel method for clinical therapy. +circulation_biomarker_diagnosis_ns 34599867 hsa-mir-1 Low Tension Glaucoma The MALAT1 level in serum of NTG patients carrying GGGT haplotype was significantly decreased compared with NTG patients carrying other haplotypes, along with elevated miR-1 expression and diminished IL-6 expression. This study presented evidence for a regulatory network containing MALAT1, miR-1 and IL-6, and further demonstrated the effect of MALAT1 haplotype on the risk and severity of NTG. +exosome 34599680 hsa-mir-1915 Colorectal Neoplasms CONCLUSION: Exosomal delivery of miR +genetics_knock down_promote 34599436 hsa-mir-744 Carcinoma, Non-Small-Cell Lung Gain- and loss-of-function experiment was performed by transfection with miR-744 agomir or antagomir in NSCLC cell lines. +lncRNA target 34599154 hsa-mir-138 Acute Lung Injury 5p promotes NLRP3-triggered inflammatory response via lncRNA NLRP3/miR +other 34599150 hsa-mir-361 Carcinoma, Hepatocellular Quantitative real-time polymerase chain reaction (qRT-PCR) was used to determine the mRNA levels of circ_0011385, miR3p, and STC2 in 96 pairs of HCC tissues (tumor tissues and adjacent normal tissues), HCC cell lines, and L02 (human normal liver cell line) cells. +epigenetics 34598837 hsa-mir-1908 Large Artery Atherosclerosis Hypomethylation of MTRNR2L8 and ER promoters; microRNAs (miR2-3p, miR-16, miR-34a-5p, miR-126, miR-143, miR-200b, miR-223, miR-503, miR-1908, miR-146a rs2910164 C/G, miR-149 rs2292832 T/C, miR-200b rs7549819 T/C, miR-34a rs2666433); lncRNA of ZFAS1; and circRNA of hsa_circRNA_102488 were associated with LAA significantly. +epigenetics 34598837 hsa-mir-223 Large Artery Atherosclerosis Hypomethylation of MTRNR2L8 and ER promoters; microRNAs (miR2-3p, miR-16, miR-34a-5p, miR-126, miR-143, miR-200b, miR-223, miR-503, miR-1908, miR-146a rs2910164 C/G, miR-149 rs2292832 T/C, miR-200b rs7549819 T/C, miR-34a rs2666433); lncRNA of ZFAS1; and circRNA of hsa_circRNA_102488 were associated with LAA significantly. +epigenetics 34598837 hsa-mir-503 Large Artery Atherosclerosis Hypomethylation of MTRNR2L8 and ER promoters; microRNAs (miR2-3p, miR-16, miR-34a-5p, miR-126, miR-143, miR-200b, miR-223, miR-503, miR-1908, miR-146a rs2910164 C/G, miR-149 rs2292832 T/C, miR-200b rs7549819 T/C, miR-34a rs2666433); lncRNA of ZFAS1; and circRNA of hsa_circRNA_102488 were associated with LAA significantly. +epigenetics 34598837 hsa-mir-34a Large Artery Atherosclerosis Hypomethylation of MTRNR2L8 and ER promoters; microRNAs (miR2-3p, miR-16, miR-34a-5p, miR-126, miR-143, miR-200b, miR-223, miR-503, miR-1908, miR-146a rs2910164 C/G, miR-149 rs2292832 T/C, miR-200b rs7549819 T/C, miR-34a rs2666433); lncRNA of ZFAS1; and circRNA of hsa_circRNA_102488 were associated with LAA significantly. +epigenetics 34598837 hsa-mir-7-2 Large Artery Atherosclerosis Hypomethylation of MTRNR2L8 and ER promoters; microRNAs (miR2-3p, miR-16, miR-34a-5p, miR-126, miR-143, miR-200b, miR-223, miR-503, miR-1908, miR-146a rs2910164 C/G, miR-149 rs2292832 T/C, miR-200b rs7549819 T/C, miR-34a rs2666433); lncRNA of ZFAS1; and circRNA of hsa_circRNA_102488 were associated with LAA significantly. +epigenetics 34598837 hsa-mir-143 Large Artery Atherosclerosis Hypomethylation of MTRNR2L8 and ER promoters; microRNAs (miR2-3p, miR-16, miR-34a-5p, miR-126, miR-143, miR-200b, miR-223, miR-503, miR-1908, miR-146a rs2910164 C/G, miR-149 rs2292832 T/C, miR-200b rs7549819 T/C, miR-34a rs2666433); lncRNA of ZFAS1; and circRNA of hsa_circRNA_102488 were associated with LAA significantly. +epigenetics 34598837 hsa-mir-146a Large Artery Atherosclerosis Hypomethylation of MTRNR2L8 and ER promoters; microRNAs (miR2-3p, miR-16, miR-34a-5p, miR-126, miR-143, miR-200b, miR-223, miR-503, miR-1908, miR-146a rs2910164 C/G, miR-149 rs2292832 T/C, miR-200b rs7549819 T/C, miR-34a rs2666433); lncRNA of ZFAS1; and circRNA of hsa_circRNA_102488 were associated with LAA significantly. +epigenetics 34598837 hsa-mir-16 Large Artery Atherosclerosis Hypomethylation of MTRNR2L8 and ER promoters; microRNAs (miR2-3p, miR-16, miR-34a-5p, miR-126, miR-143, miR-200b, miR-223, miR-503, miR-1908, miR-146a rs2910164 C/G, miR-149 rs2292832 T/C, miR-200b rs7549819 T/C, miR-34a rs2666433); lncRNA of ZFAS1; and circRNA of hsa_circRNA_102488 were associated with LAA significantly. +epigenetics 34598837 hsa-mir-200b Large Artery Atherosclerosis Hypomethylation of MTRNR2L8 and ER promoters; microRNAs (miR2-3p, miR-16, miR-34a-5p, miR-126, miR-143, miR-200b, miR-223, miR-503, miR-1908, miR-146a rs2910164 C/G, miR-149 rs2292832 T/C, miR-200b rs7549819 T/C, miR-34a rs2666433); lncRNA of ZFAS1; and circRNA of hsa_circRNA_102488 were associated with LAA significantly. +epigenetics 34598837 hsa-mir-126 Large Artery Atherosclerosis Hypomethylation of MTRNR2L8 and ER promoters; microRNAs (miR2-3p, miR-16, miR-34a-5p, miR-126, miR-143, miR-200b, miR-223, miR-503, miR-1908, miR-146a rs2910164 C/G, miR-149 rs2292832 T/C, miR-200b rs7549819 T/C, miR-34a rs2666433); lncRNA of ZFAS1; and circRNA of hsa_circRNA_102488 were associated with LAA significantly. +genetics_overexpression_promote 34598688 hsa-mir-17 Squamous Cell Carcinoma of Head and Neck 5p blocked HNSCC cells in G2/M phase, whereas its overexpression propelled cell cycle progression. +lncRNA target 34598322 hsa-mir-29c Carcinoma, Renal Cell Moreover, we concluded that H19-miR-29c-3p-COL1A1 axis might promote the polarization of M2 macrophages and inhibit M1 macrophage activation through Wnt signaling pathway, collaborating to promote PRCC tumorigenesis and lead to poor overall survival of PRCC patients. +lncRNA target 34597997 hsa-mir-342 Osteosarcoma Furthermore, inhibiting miR +transcription factor target 34596809 hsa-mir-539 Colonic Neoplasms CONCLUSION: Re-WSP1 suppresses colon cancer cell growth via the miR-539/beta-catenin axis. +genetics_GWAS 34596730 hsa-mir-548b Lung Neoplasms A novel regQTL-SNP, rs3768617, might affect lung cancer risk by modulating the expression patterns of miRNA-548b-3p and LAMC1. +genetics_GWAS 34596578 hsa-mir-146a Diabetes Mellitus, Type 2 We selected miR-146a rs2910164 C>G, miR-196a2 rs11614913 T>C and miR-499 rs3746444 A>G loci and carried out an investigation to identify whether these miR loci could influence T2DM occurrence. +genetics_GWAS 34596578 hsa-mir-196a Diabetes Mellitus, Type 2 We selected miR-146a rs2910164 C>G, miR-196a2 rs11614913 T>C and miR-499 rs3746444 A>G loci and carried out an investigation to identify whether these miR loci could influence T2DM occurrence. +genetics_GWAS 34596578 hsa-mir-499 Diabetes Mellitus, Type 2 We selected miR-146a rs2910164 C>G, miR-196a2 rs11614913 T>C and miR-499 rs3746444 A>G loci and carried out an investigation to identify whether these miR loci could influence T2DM occurrence. +other 34596365 hsa-mir-574 Lung Neoplasms Hence, we describe a novel function of miR5p unique to adenocarcinoma. +lncRNA target 34596354 hsa-let-7b Osteoporosis OPG, miR5p, and let-7b-5p in ASC-EVs inhibit osteoclast differentiation and reduce gene expression related to bone resorption, suggesting that ASC-EVs are highly promising as cell-free therapeutic agents for osteoporosis treatment. +lncRNA target 34596354 hsa-mir-21 Osteoporosis OPG, miR5p, and let-7b-5p in ASC-EVs inhibit osteoclast differentiation and reduce gene expression related to bone resorption, suggesting that ASC-EVs are highly promising as cell-free therapeutic agents for osteoporosis treatment. +transcription factor target 34596215 hsa-mir-20b Colorectal Neoplasms In this study, we demonstrated the role of miR-20b-5p-regulated syndecan-2 (SDC2) in 5-FU resistance of CRC cells. These findings showed that JNK/ERK signaling pathway is involved in miR-20b-5p/SDC2 axis-mediated 5-FU resistance in SW480/5-FU cells, indicating that the miR-20b-5p/SDC2 axis is a potential target for reversing 5-FU resistance in CRC. +circulation_biomarker_diagnosis_up 34596006 hsa-mir-3200 Carcinoma, Hepatocellular phenylindole; DARS-AS1: DARS1 antisense RNA 1; DEPC: diethyl pyrocarbonate; DMEM-F12: Dulbecco's minimal essential medium/Ham's-F12; EMT: epithelial-mesenchymal transition; ERK: extracellular signal-regulated kinase; FAK: focal adhesion kinase; FBS: fetal bovine serum; GAPDH: glyceraldehyde +lncRNA target 34595994 hsa-mir-488 Ovarian Neoplasms In summary, LncRNA CASC9 played a regulative role in ovarian carcinoma by cyclinG1/TP53/MMP7 signaling via binding to miR3p in vivo and in vitro. +genetics_knock down_suppress 34595849 hsa-mir-501 Kidney Neoplasms 3p/WTAP/CDK2 axis and is inhibited by the overexpression of miR +target gene 34595351 hsa-mir-29c Fibrosis, Renal CONCLUSION: Dysregulation of miR-29c-3p and Fer plays a role in RF. +lncRNA target 34595348 hsa-mir-23b Nance-Horan syndrome In conclusion, lncRNA NEAT1 as a ceRNA can adsorb miR-23b-3p and promote the expression of CYP1A2, which then inhibits the osteogenic differentiation of hBMSCs and promotes the progress of SNFH. +other 34595235 hsa-mir-933 Heart Failure The findings suggested a potential hsa-miR-933/RELB/CCL21 regulatory axis correlated with HF and neurological disorders (or cognitive impairment), according to PPI networks. +lncRNA target 34595165 hsa-mir-1307 Urinary Bladder Neoplasms Taken together, our results demonstrated that circPPP1CB participates in tumor growth, metastasis, and EMT process by interacting with the miR3p/SMG1 axis, and that circPPP1CB might be a novel therapeutic target and diagnostic biomarker in human BC. +lncRNA target 34594577 hsa-mir-485 Alzheimer Disease 5p ameliorates AD progression by targeting PACS1. +target gene 34594415 hsa-mir-122 Acute Lung Injury miR-122-5p downregulation attenuates lipopolysaccharide-induced acute lung injury by targeting IL1RN. +circRNA target 34594413 hsa-mir-582 Carcinoma, Hepatocellular 3p axis may represent a potential target for HCC diagnosis and treatment. +target gene 34594410 hsa-mir-345 Pancreatic Neoplasms Silencing of long non-coding RNA SNHG15 suppresses proliferation, migration and invasion of pancreatic cancer cells by regulating the microRNA-345-5p/RAB27B axis. +other 34594378 hsa-mir-642a Carcinoma, Hepatocellular CONCLUSION: Taken together, it is the first time we discovered the interaction of NR2F1-AS1 with miR-642a in modulating HCC cell invasion and migration. +lncRNA target 34594374 hsa-mir-490 Stomach Neoplasms DTL was the target of and inversely associated with miR +other 34594360 hsa-mir-126 Hypertension The expression of miR3p and 182-5p was significantly higher in known hypertensives relative to both screen-detected hypertensives and normotensives, and also in screen-detected hypertensives vs normotensives. +other 34594360 hsa-mir-182 Hypertension The expression of miR3p and 182-5p was significantly higher in known hypertensives relative to both screen-detected hypertensives and normotensives, and also in screen-detected hypertensives vs normotensives. +other 34593980 hsa-let-7b Neonatal Encephalopathy This finding of the Hippo-YAP association with let-7b needs validation in larger cohorts to further our knowledge on let-7b-5p as a biomarker for neonatal encephalopathy. +genetics_knock down_promote 34593318 hsa-mir-28 Breast Neoplasms CONCLUSION: Circ-RPPH1 knockdown retarded cell malignant phenotypes and glycolysis via miR +lncRNA target 34592963 hsa-mir-1226 Periodontitis BACKGROUND: miR-1226 has been reported to be dysregulated in periodontitis, implying its potential functional role, which needs to be validated. +genetics_overexpression_suppress 34592939 hsa-mir-105 Colorectal Neoplasms It was verified through rescue assays that RAB22A overexpression or miR +exosome 34592902 hsa-mir-4488 Vitreoretinopathy, Proliferative However, the roles of exosomal miR-4488 and miR-1273 g-5p in PVR progression have not been demonstrated. +exosome 34592902 hsa-mir-1273g Vitreoretinopathy, Proliferative However, the roles of exosomal miR-4488 and miR-1273 g-5p in PVR progression have not been demonstrated. +lncRNA target 34592894 hsa-mir-497 Fractures, Bone It was concluded that LncRNA PVT1 silencing may enhance fracture healing via mediating miR +circulation_biomarker_diagnosis_up 34592889 hsa-mir-15a Osteosarcoma miR-15a was identified as a major cargo of serum-derived exosomes, and exosomes conveying miR-15a were internalized by OS cells. +genetics_overexpression_promote 34592882 hsa-mir-128 Sepsis All in all, OIP5-AS1 overexpression enhanced sepsis-induced ALI by modulating the miR +genetics_overexpression_promote 34592882 hsa-mir-128 Lung Injury All in all, OIP5-AS1 overexpression enhanced sepsis-induced ALI by modulating the miR +transcription factor target 34592879 hsa-mir-379 Carcinoma, Non-Small-Cell Lung We demonstrated that HC0074027 promotes NSCLC chemoresistance via sequestering miR +genetics_GWAS 34592792 hsa-mir-195 Atherosclerosis In summary, our results revealed a novel mechanism that transcriptional and epigenetic regulation of miR3p inhibits macrophage inflammation through targeting IL-31, which provides a candidate diagnostic marker and novel therapeutic target in cardiovascular diseases induced by Hcy. +circRNA target 34592064 hsa-mir-16 Osteosarcoma 5p via Starbase. +lncRNA target 34591706 hsa-mir-4677 Urinary Bladder Neoplasms CONCLUSIONS: LINC00265 promotes the viability, proliferation, and migration of BCa cells by binding with miR3p to upregulate FGF6 expression. +genetics_overexpression_promote 34591390 hsa-mir-34a Laryngeal Neoplasms Moreover, miR-34a overexpression reduced the enchaining effects of prominin 1 on LC cell proliferation. +genetics_overexpression_promote 34591388 hsa-mir-24 Lymphoma, Mantle-Cell 3p overexpression led to an increased apoptotic rate of MCL cells. +other 34591387 hsa-mir-505 Stomach Neoplasms Therefore, MAFG-AS1 might upregulate PLK1 by sponging miR-505 to promote GA cell proliferation. +lncRNA target 34591354 hsa-mir-182 Squamous Cell Carcinoma of Head and Neck 5p and its predicted target kinectin 1 (KTN1) in oral squamous cell carcinoma (OSCC). +genetics_knock down_suppress 34590382 hsa-mir-30 Neurotoxicity Syndromes 3p inhibition on Sev-induced neurotoxicity could be offset by ULK1 knockdown or further intensified by Dex treatment. +lncRNA target 34590156 hsa-mir-9 Prostatic Neoplasms After PC3 cells were transfected with miR9 inhibitor or treated with curcumol, the expression levels of the PDK1/AKT/mTOR signaling pathwayrelated proteins [PDK1, phosphorylated (p)AKT and pmTOR] were increased or decreased, respectively. The present study found that curcumol regulates the PDK1/AKT/mTOR signaling pathway via miR9 and affects the development of prostate cancer. +exosome 34589894 hsa-mir-146a Alzheimer Disease The present study indicates that following an EE, exosomal miR-146a derived from the CP cells is a key factor in ameliorating astrocytic inflammation, leading to synaptogenesis and correction of cognitive impairment. +genetics_knock down_promote 34589612 hsa-mir-513b Retinoblastoma In addition, miR-513b-5p mimics neutralized the effects of TRIB1 overexpression on the proliferation and apoptosis of Weri-RB1 cells. +lncRNA target 34589581 hsa-mir-30 Colorectal Neoplasms Rescue experiments demonstrated that FGD5-AS1 promotes glycolysis through modulating the miR3p-HK2 axis, leading to 5-Fu resistance of CRC cancer cells. +lncRNA target 34589581 hsa-mir-30 Colonic Neoplasms Rescue experiments demonstrated that FGD5-AS1 promotes glycolysis through modulating the miR3p-HK2 axis, leading to 5-Fu resistance of CRC cancer cells. +transcription factor target 34589519 hsa-mir-378a Asthma Conclusion: Our findings suggest that miR-378a-3p/GRB2 pathway regulates the polarization of alveolar macrophages which acts as a potential therapeutic target for airway inflammation and remodeling in asthma. +circulation_biomarker_diagnosis_up 34589435 hsa-mir-1228 Pancreatic Carcinoma The diagnostic value of plasma-derived Exo-miR-19b normalized using miR-1228 is superior to that of serum CA19-9 in differentiating patients with Pca from healthy volunteers. +other 34589382 hsa-mir-1287 Ischemic Stroke Previous studies have indicated that miR5p was downregulated in patients with ischemic stroke. +other 34589284 hsa-mir-7 Diabetes Mellitus, Type 1 MicroRNA (miR)-7 has been demonstrated to be necessary and sufficient to repress the autophagy pathway in cell models of the disease, but the origin of its low levels in DM1 was unknown. +genetics_knock down_promote 34589278 hsa-mir-497 Stomach Neoplasms Furthermore, overexpression of miR-497 inhibited the metastasis of GC cells in vivo, which could be counteracted by CDC42 restoration. +other 34589277 hsa-mir-218 Choroidal Neovascularization In vivo, intravitreal injection of miR-218 reduced retinal EC proliferation accompanied by MYC repression, attenuated pathological choroidal neovascularization, and rescued retinal EC hyper-sprouting induced by Notch blockade. +transcription factor target 34589277 hsa-mir-218 Neovascularization, Pathologic In summary, miR-218 mediates the effect of Notch activation of EC quiescence via MYC and is a potential treatment for angiogenesis-related diseases. +transcription factor target 34589273 hsa-mir-21 Intestinal Diseases The present study suggested that naringin promoted M2 polarization via the PPARgamma/miR-21 axis, thus relieving sepsis-induced intestinal injury. +transcription factor target 34589273 hsa-mir-21 Sepsis The present study suggested that naringin promoted M2 polarization via the PPARgamma/miR-21 axis, thus relieving sepsis-induced intestinal injury. +genetics_overexpression_promote 34589270 hsa-mir-29a Ovarian Neoplasms Overexpressed miR-29a-3p was detected in OC, and miR-29a-3p promoted OC cell proliferation and immune escape. +other 34589151 hsa-mir-299 Uterine Cervical Neoplasms Long non-coding RNA UCA1 enhances cervical cancer cell proliferation and invasion by regulating microRNA-299-3p expression. +genetics_knock down_promote 34589042 hsa-mir-340 Glioblastoma The cell proliferation assay showed that circNF1 siRNA silencing and miR-340 overexpression decreased the proliferation of GBM cells. +genetics_knock down_promote 34589042 hsa-mir-340a Glioblastoma The cell proliferation assay showed that circNF1 siRNA silencing and miR-340 overexpression decreased the proliferation of GBM cells. +genetics_overexpression_suppress 34588984 hsa-mir-548b Leukemia, Myelogenous, Chronic, BCR-ABL Positive miR-548b-3p was overexpressed in circ_0058493-downregulated CML cells. +transcription factor target 34588978 hsa-mir-9 Dermatitis, Atopic MiR-9, negatively regulated by HDAC6, suppressed AD by directly regulating the expression of sirtuin 1 (SIRT1). +circulation_biomarker_diagnosis_ns 34588560 hsa-mir-423 Osteoarthritis Serum expression of miR +circulation_biomarker_diagnosis_ns 34588560 hsa-mir-155 Osteoarthritis Serum expression of miR +circulation_biomarker_diagnosis_ns 34588560 hsa-mir-155 Osteoporotic Fractures Serum expression of miR +circulation_biomarker_diagnosis_ns 34588560 hsa-mir-423 Osteoporotic Fractures Serum expression of miR +circulation_biomarker_diagnosis_ns 34588560 hsa-mir-365 Osteoporotic Fractures Serum expression of miR +circulation_biomarker_diagnosis_ns 34588560 hsa-mir-365 Osteoarthritis Serum expression of miR +epigenetics 34588546 hsa-mir-200c Colorectal Neoplasms Here, we investigated 5mC and m6A in hsa-miR-200c-5p extracted from colorectal cancer cells and determined their methylation sites and rates; the data were comparable to those determined by mass spectrometry. +genetics_knock down_promote 34588094 hsa-mir-506 Carcinoma, Non-Small-Cell Lung Our study confirmed the exact roles of LAMTOR5-AS1 for the first time and revealed that LAMTOR5-AS1 knockdown disrupts the malignancy of NSCLC by targeting the miR +transcription factor target 34587879 hsa-mir-218 Cardiomyopathies 5p plays an important role in myocardial fibrosis after MI by targeting CX43. +transcription factor target 34587879 hsa-mir-218 Myocardial Infarction 5p plays an important role in myocardial fibrosis after MI by targeting CX43. +genetics_knock down_suppress 34587874 hsa-mir-378a Squamous Cell Carcinoma of Head and Neck In conclusion, our data suggested that YEATS2 expression was regulated by miR-378a-5p and YEATS2 knockdown inhibited proliferation and metastasis while induced apoptosis in HNSCC cells. +genetics_overexpression_promote 34587717 hsa-mir-29a Squamous Cell Carcinoma of Head and Neck Overexpression of miR-29a-3p resulted in suppressed cell viability, proliferation, migration ability and increased cell apoptosis, while this expression pattern can be partially counteracted by ADAM12 overexpression in OSCC cells. +lncRNA target 34587435 hsa-mir-149 Stomach Neoplasms 5p might be a target of LINC01420 and mediate the effects of LINC01420 on GCa cell proliferation and migration and invasion. +other 34587228 hsa-mir-1246 Leukemia, Myeloid, Acute Proof-of-concept studies using a murine model and patient-derived xenografts demonstrate the feasibility of developing miR-1246, as a potential minimally invasive AML biomarker. +genetics_knock down_promote 34587164 hsa-mir-20a Leukemia, Myeloid, Acute Furthermore, PPP6C knockdown imitated, while overexpression reversed the effects of miR-20a-5p overexpression on AML cell proliferation, cell cycle G1/S transition and apoptosis. +genetics_overexpression_promote 34587154 hsa-mir-195 Prostatic Neoplasms Databases identified several miRNAs capable of binding COMT and of these, miR-195 was observed to be increased in prostate cancer according to TCGA. Real-time PCR validated upregulation of miR-195 in clinical prostate cancer specimens as well as DuPro and DU145 and interestingly, luciferase reporter showed miR-195 capable of binding COMT and overexpressing miR-195 could reduce COMT in cells. +lncRNA target 34586953 hsa-mir-650 Stomach Neoplasms These findings indicate that targeting DICER-AS1 and miR-650 could be a novel treatment for gastric cancer. +circulation_biomarker_diagnosis_up 34586739 hsa-mir-26b Pancreatitis, Chronic "3p was associated with a ""consequence"" of ""cancer"" and miR-26b-5p as a ""cause"" of ""pancreatitis."" A subgroup analysis revealed that blood small EV miR" +circulation_biomarker_diagnosis_up 34586739 hsa-mir-26b Carcinoma, Pancreatic Ductal "3p was associated with a ""consequence"" of ""cancer"" and miR-26b-5p as a ""cause"" of ""pancreatitis."" A subgroup analysis revealed that blood small EV miR" +circulation_biomarker_diagnosis_up 34586739 hsa-mir-95 Pancreatitis, Chronic "3p was associated with a ""consequence"" of ""cancer"" and miR-26b-5p as a ""cause"" of ""pancreatitis."" A subgroup analysis revealed that blood small EV miR" +circulation_biomarker_prognosis_ns 34586739 hsa-mir-340 Pancreatitis, Chronic 3p/miR-26b-5p and its combination with serum levels of CA19-9 could separate PDAC from CP, and miR +circulation_biomarker_prognosis_ns 34586739 hsa-mir-340 Carcinoma, Pancreatic Ductal 3p/miR-26b-5p and its combination with serum levels of CA19-9 could separate PDAC from CP, and miR +circulation_biomarker_prognosis_ns 34586739 hsa-mir-335 Carcinoma, Pancreatic Ductal 3p/miR-26b-5p and its combination with serum levels of CA19-9 could separate PDAC from CP, and miR +circulation_biomarker_prognosis_ns 34586739 hsa-mir-335 Pancreatitis, Chronic 3p/miR-26b-5p and its combination with serum levels of CA19-9 could separate PDAC from CP, and miR +circulation_biomarker_diagnosis_up 34586739 hsa-mir-95 Carcinoma, Pancreatic Ductal "3p was associated with a ""consequence"" of ""cancer"" and miR-26b-5p as a ""cause"" of ""pancreatitis."" A subgroup analysis revealed that blood small EV miR" +lncRNA target 34586738 hsa-mir-145 esophagus adenocarcinoma 5p and inhibiting SPOP-dependent ubiquitination and degradation of PD-L1, thus, presenting new target for EAC adjunct therapy. +exosome 34586722 hsa-mir-19b Adenocarcinoma of Lung RBMX bound to miR-19b-3p to facilitate the packaging of miR-19b-3p into LUAD cell-derived exosomes. +genetics_overexpression_promote 34586647 hsa-mir-138 Carcinoma, Renal Cell 5p could hinder KIRC proliferation and invasion, while artificial overexpression of SIN3A led to reversed trends. +lncRNA target 34586488 hsa-mir-519d Carcinoma, Non-Small-Cell Lung The restoration of miR-519d-3p in these NSCLC cells inhibited cell proliferation, invasion and migration; enhanced cell sensitivity to gefitinib. +genetics_overexpression_promote 34585634 hsa-mir-195 Nasopharyngeal Carcinoma 3p, and CDK1 overexpression counteracted the effects of miR +lncRNA target 34585626 hsa-mir-132 Alzheimer Disease 3p reduces apoptosis of SH-SY5Y cells and alleviates impairments of learning and memory abilities in AD rats by modulating the HNRNPU/BACE1 axis. +lncRNA target 34585441 hsa-mir-449c Ischemic Stroke Collectively, SNHG8 inhibits microglia activation and BBB permeability via the miR-449c-5p/SIRT1/FoxO1 pathway, thus eliciting protective effects on ischemic brain injury. +exosome 34585365 hsa-mir-186 Fibrosis, Renal Moreover, exosomal miR +lncRNA target 34584571 hsa-mir-125b Carcinoma, Hepatocellular Taken together, the findings from the present study demonstrated that CYTOR could promote cell proliferation and tumor growth by sponging miR-125b and upregulating SEMA4C, which suggested that CYTOR may act as a potential therapeutic target in HCC. +other 34584569 hsa-mir-589 Pancreatic Neoplasms A novel long non-coding RNA TTN-AS1/microRNA-589-5p/FOXP1 positive feedback loop increases the proliferation, migration and invasion of pancreatic cancer cell lines. +other 34584554 hsa-mir-96 Infertility Therefore, miR5p may serve as a potential biomarker for male infertility. +other 34584554 hsa-mir-96 Infertility, Male Therefore, miR5p may serve as a potential biomarker for male infertility. +transcription factor target 34584553 hsa-mir-15b Aortic Aneurysm, Abdominal The present study aimed to explain the roles of miR-15b/ACSS2 in AAA by exploring their effects on the proliferation and apoptosis of aortic VSMCs. The present study provided preliminary evidence indicating that the miR-15b-5p/ACSS2/PTGS2 axis may be a potential target for the treatment of AAA. +target gene 34584550 hsa-mir-28 Prostatic Neoplasms miR-28-3p inhibits prostate cancer cell proliferation, migration and invasion, and promotes apoptosis by targeting ARF6. +target gene 34584547 hsa-mir-875 Urinary Bladder Neoplasms lncRNA LOC339524 inhibits the proliferation of bladder cancer cells by targeting the miR-875-5p/COPS7A signaling axis. +lncRNA target 34584454 hsa-mir-1306 Osteosarcoma 5p remarkably inhibits the malignant behavior of OS cells. +genetics_overexpression_promote 34583851 hsa-mir-614 Sleep Apnea, Obstructive The suppression of silencing RGMB-AS1 on OSA cell progression was rescued by ANKRD1 overexpression or miR +lncRNA target 34583641 hsa-mir-29b-1 Multiple Sclerosis qPCR showed that MAPK6 and MMP19, targets of miR-301b-3p, were upregulated in MS and reversed by Enr. +other 34583641 hsa-mir-29 Multiple Sclerosis RESULTS: MS, Enr, RS, and sex altered hypothalamic miRNAs, including several previously reported in MS literature: miRs-29, - 124, - 132, - 144, - 504. +epigenetics 34583641 hsa-mir-219a Multiple Sclerosis Additionally, miR-219a was hypermethylated in MS coinciding with decreased miR-219a expression. +genetics_knock down_promote 34583623 hsa-mir-519d Retinoblastoma CONCLUSION: PROX1-AS1 knockdown upregulates miR-519d-3p to promote chemosensitivity of RB cells via targeting SOX2. +lncRNA target 34583619 hsa-mir-136 Adrenocorticotropic hormone deficiency CONCLUSION: NORAD suppressed miR +lncRNA target 34583064 hsa-mir-708 Carcinoma, Hepatocellular 5p, as a HBV-related miRNA, was a potential target of LINC01232, and was negatively correlated with LINC01232 in HCC. +genetics_overexpression_promote 34582975 hsa-mir-127 Glioblastoma 3p overexpression alleviated this effect. +transcription factor target 34582743 hsa-mir-1306 Diabetes Mellitus In conclusion, quercetin inhibits ER stress and improves testosterone secretion disorder through the miR +transcription factor target 34582743 hsa-mir-1306 Testicular Diseases In conclusion, quercetin inhibits ER stress and improves testosterone secretion disorder through the miR +transcription factor target 34582697 hsa-mir-221 Prostatic Neoplasms CELSR3 seems to play a pivotal role in MPCa by affecting the focal adhesion pathway and/or being targeted by miRNA +lncRNA target 34582667 hsa-mir-27a Carcinoma, Hepatocellular CONCLUSION: The present data demonstrated targeting miR-27a enhances the anti-tumor effect of SOR in HCC cell lines considering as one of the promising therapeutic targets for advanced HCC management. +other 34582645 hsa-mir-199a Carcinoma, Hepatocellular We aimed at investigating microRNA-199 as a potential therapeutic tool for HCC both in vitro and in an experimental model. Histopathological examination of liver specimens after miRNA 199a treatment showed regression of Hepatocellular carcinoma with restoration of normal architecture. +transcription factor target 34582541 hsa-mir-20a Lung Neoplasms These findings provide a new and promising anticancer strategy via the use of Au-RGD-miR-320a nanoparticles, and identify miR-320a/Sp1 as a potential target for future systemic therapy against lung cancer. +lncRNA target 34582362 hsa-mir-20 Cardiomyopathies MiR-320 mimics accelerated cardiac hypertrophy and cardiac fibrosis via the IL6/STAT3/PTEN axis. +lncRNA target 34582362 hsa-mir-20 Cardiomegaly MiR-320 mimics accelerated cardiac hypertrophy and cardiac fibrosis via the IL6/STAT3/PTEN axis. +circulation_biomarker_diagnosis_up 34582317 hsa-mir-23b Pulmonary Arterial Hypertension CONCLUSION: The expression level of miR-23b was remarkably up-regulated in serum of CHD patients and H9C2 cells in vitro, while the expression of GATA6 and IGF-1 was significantly decreased. +exosome 34581942 hsa-mir-125a Wounds and Injuries MiR-125a-3p from the HADSCs-exosome promoted the wound healing and angiogenesis, and these effects were achieved through regulating PTEN. +other 34581937 hsa-mir-708 Cranial Nerve Injuries After sciatic nerve injury, miR708-5p was highly expressed in neuregulin-treated Schwann cells, whereas it was downregulated during postnatal development. +other 34581937 hsa-mir-708 Sciatic Neuropathy After sciatic nerve injury, miR708-5p was highly expressed in neuregulin-treated Schwann cells, whereas it was downregulated during postnatal development. +other 34581616 hsa-mir-140 Hyperostosis RESULTS: Pretreatment of MSCs with miR-140 significantly increased the expression of cartilage-specific genes (COL2A1, SOX9, and ACAN) with reduced hypertrophic chondrocyte (COL10A1) marker expression and better safranin-O staining than the control. +lncRNA target 34580912 hsa-mir-21 Brain Ischemia Then, the mechanisms of the neuroprotective effects of BBE were investigated in the injury through evaluating miR-146a, miR-21, and their targets in a CIRI rat model. +lncRNA target 34580912 hsa-mir-146a Brain Ischemia Then, the mechanisms of the neuroprotective effects of BBE were investigated in the injury through evaluating miR-146a, miR-21, and their targets in a CIRI rat model. +other 34580516 hsa-mir-16 Pre-Eclampsia CONCLUSIONS: Deregulated micro ribonucleic acid-16 along with differentially expressed apoptotic genes, survivin and tumour protein p53 might result in altered apoptosis implicated in the pathogenesis of preeclampsia. +lncRNA target 34580402 hsa-mir-16 Sarcopenia Therefore, miR5p can be a novel therapeutic target in the context of cardiac repair disturbances in sarcopenia-cachexia. +lncRNA target 34579548 hsa-mir-125b Pancreatic Carcinoma Conclusion: M2-targeted HA-PEI/PEG nanoparticles with miR-125b can transfect tumor-associated macrophages in pancreatic tissues and may have implications for PDAC immunotherapy. +circulation_biomarker_prognosis_up 34577789 hsa-mir-497 Carcinoma, Hepatocellular Results: Serum miR-497 showed statistically significant downregulation in HCC patients compared to controls (p < 0.001). +other 34576290 hsa-mir-203 Hypertension These results indicate that IH stress downregulates the miR-203 in renin-producing cells, thereby resulting in increased mRNA levels of Ren and Cd38, which leads to hypertension. +genetics_GWAS 34576267 hsa-mir-499 Hashimoto Thyroiditis We examined whether miR-499 rs3746444 polymorphism is associated with susceptibility to HT in an Iranian subpopulation. +transcription factor target 34576110 hsa-mir-139 Squamous Cell Carcinoma of Head and Neck 3p in HNSCC cells was confirmed through luciferase reporter assays. +lncRNA target 34576039 hsa-mir-490 Colorectal Neoplasms Thus, we have clarified a part of the molecular pathway of CRC based on the action of tumor-suppressive miR +other 34575979 hsa-mir-133a Colonic Neoplasms Further investigations showed a role of TPM4 in cancer physiology, specifically, we found that miR-133a downregulation leads to TPM4 upregulation in colon carcinoma (CRC), and this correlates with a lower patient survival. Interestingly, in CRC cell lines and in patient biopsies, miR-133a is able to regulate TPM4 activity, while TAp63 is not active. +other 34575957 hsa-mir-214 Liver Diseases Performing miRNA-seq of cell culture supernatants, we identified potential miRNA biomarkers (miR-199a-5p, miR3p, niRNA-125a-5p and miR-99b-5p) that were associated with a fibrotic phenotype and not with hepatocellular damage alone. +other 34575957 hsa-mir-199a Liver Diseases Performing miRNA-seq of cell culture supernatants, we identified potential miRNA biomarkers (miR-199a-5p, miR3p, niRNA-125a-5p and miR-99b-5p) that were associated with a fibrotic phenotype and not with hepatocellular damage alone. +other 34575957 hsa-mir-99b Fibrosis 3p and miR-99b-5p are promoters of HSC activation. +other 34575957 hsa-mir-99b Liver Diseases Performing miRNA-seq of cell culture supernatants, we identified potential miRNA biomarkers (miR-199a-5p, miR3p, niRNA-125a-5p and miR-99b-5p) that were associated with a fibrotic phenotype and not with hepatocellular damage alone. +other 34575957 hsa-mir-214 Fibrosis 3p and miR-99b-5p are promoters of HSC activation. +other 34575957 hsa-mir-199a Fibrosis 3p and miR-99b-5p are promoters of HSC activation. +other 34575957 hsa-mir-125a Fibrosis 3p and miR-99b-5p are promoters of HSC activation. +other 34575936 hsa-mir-144 beta-Thalassemia 3p was strongly increased; betaT-EVs induced apoptosis and decreased endothelial, pancreatic, and liver cell survival while supporting BM-MSC proliferation. +other 34575699 hsa-mir-20a Autism Spectrum Disorder Verification with qRT-PCR showed that miR-320a differentiated ASD from both sibling and unrelated controls and that several members of the miR-181 family differentiated ASD from unrelated controls. +other 34575699 hsa-mir-181 Autism Spectrum Disorder Verification with qRT-PCR showed that miR-320a differentiated ASD from both sibling and unrelated controls and that several members of the miR-181 family differentiated ASD from unrelated controls. +genetics_GWAS 34575638 hsa-mir-126 Diabetes Mellitus, Type 2 Results indicated that there was a significant different (p-value < 0.05) in the Mir126 rs4636297 genotypes distribution between cases and controls, and the minor allele of the rs4636297 was also associated with T2D with OR = 0.58, p-value < 0.05. We conclude that the Mir126 rs4636297 and PIK3R1 SNPs (rs7713645 and rs3730089) were associated with T2D. +lncRNA target 34575183 hsa-mir-379 Breast Neoplasms The target mRNAs (validated) of MiR-379/656 were annotated via pathway enrichment analysis to understand the biological significance of the cluster in breast cancer. +other 34574169 hsa-mir-222 Diabetes Mellitus After analysing these results, a potential involvement of the reduced expression of miR-30c and miR-222, two microRNAs associated with insulin resistance and diabetes, in the improvement of glycaemic control produced by grape pomace administration, can be proposed. +other 34574169 hsa-mir-222 Insulin Resistance After analysing these results, a potential involvement of the reduced expression of miR-30c and miR-222, two microRNAs associated with insulin resistance and diabetes, in the improvement of glycaemic control produced by grape pomace administration, can be proposed. +circulation_biomarker_diagnosis_ns 34574047 hsa-mir-431 Precancerous Conditions In summary, our data reveal the diagnostic potential of circulating miR +circulation_biomarker_diagnosis_ns 34574047 hsa-mir-431 vulva squamous cell carcinoma In summary, our data reveal the diagnostic potential of circulating miR +circulation_biomarker_diagnosis_ns 34574045 hsa-mir-122 Hyperparathyroidism, Primary In conclusion, preoperative circulating miR5p and miR-375 levels were negatively associated with TH BMD changes after parathyroidectomy in PHPT patients. +circulation_biomarker_diagnosis_ns 34574045 hsa-mir-375 Hyperparathyroidism, Primary In conclusion, preoperative circulating miR5p and miR-375 levels were negatively associated with TH BMD changes after parathyroidectomy in PHPT patients. +genetics_overexpression_promote 34573382 hsa-mir-200c Carcinoma, Ovarian Epithelial Our results suggest that inhibition of high expression of miR-200c-3p in EOC might lead to overexpression of the tumor suppressor PPP3CC and subsequent induction of apoptosis in EOC patients. +other 34573283 hsa-mir-200c Burkitt Lymphoma This study therefore identifies novel miRNAs as role players in the development of HIV-associated BL, with one of these miRNAs, hsa-miR-200c-3p, being a candidate for further clinical studies as a potential biomarker for prognosis in patients with Burkitt lymphoma, who are HIV positive. +transcription factor target 34573085 hsa-mir-43 Inflammation These results suggested that ME might alleviate obesity-induced inflammation and mitochondrial dysfunction by regulating miR-21, miR-132, and miR-43 expression in WAT, and by activating the PGC-1alpha/SIRT1 pathway in muscle. +transcription factor target 34573085 hsa-mir-132 Inflammation These results suggested that ME might alleviate obesity-induced inflammation and mitochondrial dysfunction by regulating miR-21, miR-132, and miR-43 expression in WAT, and by activating the PGC-1alpha/SIRT1 pathway in muscle. +transcription factor target 34573085 hsa-mir-21 Inflammation These results suggested that ME might alleviate obesity-induced inflammation and mitochondrial dysfunction by regulating miR-21, miR-132, and miR-43 expression in WAT, and by activating the PGC-1alpha/SIRT1 pathway in muscle. +target gene 34572889 hsa-mir-137 Colorectal Neoplasms miR-137 helps control MSH2 expression via its 3'UTR and that dysregulation of this mechanism appears to promote tumorigenesis in colon cells. +other 34572843 hsa-let-7i Ovarian Neoplasms Let-7i Reduces Aggressive Phenotype and Induces BRCAness in Ovarian Cancer Cells. +other 34572608 hsa-mir-92a Brain Neoplasms 5p), assessed in CSFs, discriminated CNS DLBCL from n-ML samples with 100% specificity and 67.0% sensitivity. +other 34572608 hsa-mir-106b Primary Central Nervous System Lymphoma 5p. +other 34572608 hsa-mir-19a Primary Central Nervous System Lymphoma 5p. +other 34572608 hsa-mir-92a Primary Central Nervous System Lymphoma 5p), assessed in CSFs, discriminated CNS DLBCL from n-ML samples with 100% specificity and 67.0% sensitivity. +other 34572608 hsa-mir-15a Primary Central Nervous System Lymphoma 5p. +other 34572608 hsa-mir-19a Brain Neoplasms 5p. +other 34572608 hsa-mir-16 Primary Central Nervous System Lymphoma 5p), assessed in CSFs, discriminated CNS DLBCL from n-ML samples with 100% specificity and 67.0% sensitivity. +other 34572608 hsa-mir-21 Brain Neoplasms 5p), assessed in CSFs, discriminated CNS DLBCL from n-ML samples with 100% specificity and 67.0% sensitivity. +other 34572608 hsa-mir-26a Primary Central Nervous System Lymphoma 5p. +other 34572608 hsa-mir-26a Brain Neoplasms 5p. +other 34572608 hsa-mir-21 Primary Central Nervous System Lymphoma 5p), assessed in CSFs, discriminated CNS DLBCL from n-ML samples with 100% specificity and 67.0% sensitivity. +other 34572608 hsa-mir-16 Brain Neoplasms 5p), assessed in CSFs, discriminated CNS DLBCL from n-ML samples with 100% specificity and 67.0% sensitivity. +other 34572608 hsa-mir-15a Brain Neoplasms 5p. +other 34572608 hsa-mir-106b Brain Neoplasms 5p. +other 34572434 hsa-mir-6881 Non-alcoholic Fatty Liver Disease CONCLUSION: This pilot study concluded that HSPD1/MMP14/ITGB1/miR5P/Lnc-SPARCL1-1:2 panel expression has potential in the diagnosis of NASH, and also differentiation between NAFLD, simple steatosis and NASH cases. +other 34572434 hsa-mir-6881 Carcinoma, Hepatocellular CONCLUSION: This pilot study concluded that HSPD1/MMP14/ITGB1/miR5P/Lnc-SPARCL1-1:2 panel expression has potential in the diagnosis of NASH, and also differentiation between NAFLD, simple steatosis and NASH cases. +circulation_biomarker_diagnosis_up 34572320 hsa-mir-150 Diabetic Retinopathy In cultured photoreceptors, treatments with palmitic acid (PA), to mimic a high-fat environment, decreased miR-150 but upregulated ELK1, pELK1(T417), and the translocation of pELK1(T417) from the cytoplasm to the cell nucleus. Deletion of miR-150 (miR-150(-/-)) exacerbates T2D- or PA-induced photoreceptor apoptosis. +transcription factor target 34572124 hsa-mir-43a Depression Our results indicate that the early life gamma-radiation-activated miR-43a-5p/Tia1 pathway is involved in the pathogenesis of adult depression. This novel finding may provide a new therapeutic target by inhibiting the miR-43a-5p/Tia1 pathway to prevent radiation-induced pathogenesis of depression. +lncRNA target 34572073 hsa-mir-124 Alzheimer Disease Neuronal Dynamics and miRNA Signaling Differ between SH-SY5Y APPSwe and PSEN1 Mutant iPSC-Derived AD Models upon Modulation with miR-124 Mimic and Inhibitor. +other 34572021 hsa-mir-451a Prostatic Neoplasms The analysis of PC-related miRNA in the fraction of PSMA(+)SEVs was more sensitive and revealed distinct diagnostic potency (AUC: miR-145, 0.76; miR-221, 0.7; miR-451a, 0.65; and miR-141, 0.64) than analysis of the total SEV population. +other 34572021 hsa-mir-221 Prostatic Neoplasms The analysis of PC-related miRNA in the fraction of PSMA(+)SEVs was more sensitive and revealed distinct diagnostic potency (AUC: miR-145, 0.76; miR-221, 0.7; miR-451a, 0.65; and miR-141, 0.64) than analysis of the total SEV population. +other 34572021 hsa-mir-141 Prostatic Neoplasms The analysis of PC-related miRNA in the fraction of PSMA(+)SEVs was more sensitive and revealed distinct diagnostic potency (AUC: miR-145, 0.76; miR-221, 0.7; miR-451a, 0.65; and miR-141, 0.64) than analysis of the total SEV population. +other 34572021 hsa-mir-145 Prostatic Neoplasms The analysis of PC-related miRNA in the fraction of PSMA(+)SEVs was more sensitive and revealed distinct diagnostic potency (AUC: miR-145, 0.76; miR-221, 0.7; miR-451a, 0.65; and miR-141, 0.64) than analysis of the total SEV population. +other 34571940 hsa-mir-664a Lichen Sclerosus et Atrophicus We verified the expression of a set of miRNAs that are related to autoimmunity, such as upregulated miR-326, miR5p, miR-155 and downregulated miR-664a-3p and miR-181a-3p in LS tissue compared to the matched adjacent normal tissue. +other 34571940 hsa-mir-326 Lichen Sclerosus et Atrophicus We verified the expression of a set of miRNAs that are related to autoimmunity, such as upregulated miR-326, miR5p, miR-155 and downregulated miR-664a-3p and miR-181a-3p in LS tissue compared to the matched adjacent normal tissue. +other 34571940 hsa-mir-181a Lichen Sclerosus et Atrophicus We verified the expression of a set of miRNAs that are related to autoimmunity, such as upregulated miR-326, miR5p, miR-155 and downregulated miR-664a-3p and miR-181a-3p in LS tissue compared to the matched adjacent normal tissue. +other 34571940 hsa-mir-142 Lichen Sclerosus et Atrophicus We verified the expression of a set of miRNAs that are related to autoimmunity, such as upregulated miR-326, miR5p, miR-155 and downregulated miR-664a-3p and miR-181a-3p in LS tissue compared to the matched adjacent normal tissue. +lncRNA target 34571504 hsa-mir-425 Diabetic Retinopathy Moreover, inhibiting the expression of miR5p levels under the condition of hyperglycemia may be used as a valuable therapeutic strategy for preventing the pathogenesis of DR. +genetics_overexpression_promote 34571345 hsa-mir-144a Glioma RP1-86C11.7 overexpression in glioma cells elevated TFRC expression, increased the intracellular free iron level, and deteriorated oncogenicity, with a significant reduction in hsa-miR +genetics_overexpression_promote 34571345 hsa-mir-144 Glioma RP1-86C11.7 overexpression in glioma cells elevated TFRC expression, increased the intracellular free iron level, and deteriorated oncogenicity, with a significant reduction in hsa-miR +genetics_knock down_promote 34571083 hsa-mir-5096 Breast Neoplasms induced ferroptotic cell death in human breast cancer cells was confirmed by concurrently increased ROS, OH(-), lipid ROS, and iron accumulation levels and decreased GSH and mitochondrial membrane potential (MitoTracker Orange) with mitochondrial shrinkage and partial cristae loss (observed by TEM). +other 34571048 hsa-mir-122 Acute Coronary Syndrome 5p do not add prognostic information to hs-cTnT in patients presenting with suspected ACS to the ED. +other 34571048 hsa-mir-21 Acute Coronary Syndrome 5p do not add prognostic information to hs-cTnT in patients presenting with suspected ACS to the ED. +other 34570885 hsa-mir-125b Leukemia We report that posttranscriptional repression of the transcription factor ARID3A by miR-125b is a key event in the pathogenesis of acute megakaryoblastic leukemia (AMKL). +circulation_biomarker_diagnosis_ns 34570814 hsa-mir-630 Weil Disease Serum miR-601 and miR-630 at presentation could potentially serve as promising biomarkers for predicting subsequent acute liver failure and overall survival in patients with leptospirosis. +circulation_biomarker_diagnosis_ns 34570814 hsa-mir-601 Weil Disease Serum miR-601 and miR-630 at presentation could potentially serve as promising biomarkers for predicting subsequent acute liver failure and overall survival in patients with leptospirosis. +lncRNA target 34570663 hsa-mir-1197 Carcinoma, Hepatocellular In conclusion, circ_0004018 suppresses the proliferation and migration of HCC cells via sponging miR-1197 to inactivate the PTEN/PI3K/AKT signaling pathway.Abbreviations: HCC: Hepatocellular carcinoma; circRNAs: Circular RNAs; PTEN: Phosphatase and tensin homologue; miR-1197: microRNA-1197; ceRNA: competitive endogenous RNA; ATCC: American Type Culture Collection; EMEM: Eagle's Minimum Essential Medium; RT-qPCR: Quantitative real-time PCR; EdU: 5-ethynyl +lncRNA target 34570661 hsa-mir-200c Glioblastoma This information is exploited to evaluate the tumour suppressive function of miRNA-200c as locoregional therapeutic modality to treat glioblastoma. +other 34570349 hsa-mir-20a Stroke Intravenous injections, which are a therapeutically tractable treatment route, with miR-20a-3p mimic 4 h after middle cerebral artery occlusion (MCAo) significantly improved stroke outcomes including infarct volume and sensory motor performance. +transcription factor target 34570211 hsa-mir-204 Atherosclerosis CONCLUSION: Macrophage NFATc3 up-regulates miR-204 to reduce SR-A and CD36 levels, thereby preventing foam cell formation and atherosclerosis, indicating that the NFATc3/miR-204 axis may be a potential therapeutic target against atherosclerosis. +genetics_overexpression_suppress 34569498 hsa-mir-3929 Uterine Cervical Neoplasms Then, we analyzed the effect of miR-3929 on the biological behavior of cervical cancer cells, finding that miR-3929 could reduce cell viability, DNA synthesis, and Ki67 expression and induce cell cycle arrest in the G2/M phase; overexpression of Cripto-1 reversed the inhibitory effect of miR-3929 on proliferation. +genetics_knock down_promote 34569008 hsa-mir-615 Brachial Plexus Avulsion In this study, results indicated that hydrogel-miR-615 agomir effectively alleviated motoneuron loss by LINGO-1 inhibition, promoted musculocutaneous nerve regeneration and myelination, reduced astrocytes activation, promoted angiogenesis and attenuated peripheral amyotrophy, leading to improved motor functional rehabilitation of the upper extremity. +lncRNA target 34568801 hsa-mir-345 Polycystic liver disease targeted proteins, cell proliferation, and cyst growth in vitro. +other 34568733 hsa-mir-146a Abortion, Habitual Objective To assess the relationship of miR-146aC G (rs2910164) and miR-196a2T C (rs11614913) with RPL susceptibility in Iranian women. Conclusion The results showed that although the distribution of miR-146aC G and miR-196a2T C was different between the unknown RPL and control groups, these variances were not statistically significant. +other 34568733 hsa-mir-196a Abortion, Habitual Objective To assess the relationship of miR-146aC G (rs2910164) and miR-196a2T C (rs11614913) with RPL susceptibility in Iranian women. Conclusion The results showed that although the distribution of miR-146aC G and miR-196a2T C was different between the unknown RPL and control groups, these variances were not statistically significant. +circulation_biomarker_diagnosis_ns 34568580 hsa-mir-122 Gastritis, Atrophic CONCLUSION: These results suggested that serum exosomal hsa-miR +other 34568523 hsa-mir-432 Neurotic Disorders Together, our results indicate that ADAR1 affects CUS-induced depressive-like behavior and BDNF expression by acting on miR-432 and circ_0000418. +other 34568463 hsa-mir-183 Heart Failure 3p is an independent predictor of worsening HF and thus may be used as additional biomarker in the risk assessment of these patients. +other 34568463 hsa-mir-183 Transposition of Great Vessels 3p is an independent predictor of worsening HF and thus may be used as additional biomarker in the risk assessment of these patients. +circulation_biomarker_diagnosis_ns 34568382 hsa-mir-6869 Obesity Thus, miR5p in plasma Obese-EVs could be a therapeutic target for local RAS activation in obesity-associated kidney disease. +other 34568346 hsa-mir-423 Non-alcoholic Fatty Liver Disease These miR-374a, miR-143, miR-1, miR-23a, and miR-423 have potential for steatohepatitis diagnosis and are poorly studied in the context of NAFLD. +other 34568346 hsa-mir-374a Non-alcoholic Fatty Liver Disease These miR-374a, miR-143, miR-1, miR-23a, and miR-423 have potential for steatohepatitis diagnosis and are poorly studied in the context of NAFLD. +other 34568346 hsa-mir-23a Non-alcoholic Fatty Liver Disease These miR-374a, miR-143, miR-1, miR-23a, and miR-423 have potential for steatohepatitis diagnosis and are poorly studied in the context of NAFLD. +other 34568346 hsa-mir-1 Non-alcoholic Fatty Liver Disease 5p and miR-200c-3 in regulating apoptotic processes in the liver and hepatocarcinogenesis is of interest for future experimental studies. +other 34568346 hsa-mir-200c Non-alcoholic Fatty Liver Disease 5p and miR-200c-3 in regulating apoptotic processes in the liver and hepatocarcinogenesis is of interest for future experimental studies. +other 34568346 hsa-mir-143 Non-alcoholic Fatty Liver Disease These miR-374a, miR-143, miR-1, miR-23a, and miR-423 have potential for steatohepatitis diagnosis and are poorly studied in the context of NAFLD. +exosome 34568335 hsa-mir-375 Carcinoma, Hepatocellular Moreover, HCC-secreted EXOs mediated the degradation of miR-375 via circ-0072088 and upregulated MMP-16, thus suppressing the metastasis of HCC. +other 34568326 hsa-mir-1252 Osteosarcoma Circular RNA hsa_circ_0000073 Enhances Osteosarcoma Cells Malignant Behavior by Sponging miR-1252-5p and Modulating CCNE2 and MDM2. +lncRNA target 34568062 hsa-mir-4732 Carcinoma, Hepatocellular 3p/ULBP1 axis may regulate immune escape via PD-L1 in HCC with high TMB. +circulation_biomarker_diagnosis_ns 34567283 hsa-mir-651 Uterine Cervical Neoplasms Herein, we observed the roles of exosomal miR-651 in cisplatin resistance of cervical cancer. METHODS: Circulating miR-651 was detected in cervical cancer and healthy individuals. +genetics_overexpression_promote 34567205 hsa-let-7 Colonic Neoplasms Methods It was planned to synthesize miR-let-7 overexpression (mimics) and interference expression (inhibitor) and transiently transfect colon cancer cell HCT116, detect the expression levels of miR-let-7 and HMGA2 in the cells after transfection and the targeted regulation effect of miR-let-7 on HMGA2, then detect the effect of upregulation/downregulation of miR-let-7 on HMGA2, and detect the proliferation, migration, and invasion of HCT116 cells. +transcription factor target 34567186 hsa-mir-218 Breast Neoplasms We aimed to investigate the frequency of EBV and its relationship with expression status of tumor suppressive miR-218 in breast cancer and adjacent normal tissue. +transcription factor target 34567186 hsa-mir-218 Epstein-Barr Virus Infections We aimed to investigate the frequency of EBV and its relationship with expression status of tumor suppressive miR-218 in breast cancer and adjacent normal tissue. +other 34567091 hsa-mir-200c Carcinoma, Hepatocellular Result: The key regulatory genes including EXO1, VCAN, KIT, and hsa-miR-200c-5p were found to play vital roles in HCV-HCC development. +other 34567091 hsa-mir-200c Hepatitis C Result: The key regulatory genes including EXO1, VCAN, KIT, and hsa-miR-200c-5p were found to play vital roles in HCV-HCC development. +circulation_biomarker_diagnosis_ns 34567071 hsa-mir-146a Heart Septal Defects, Ventricular hsa-miR-146a-5p was identified to be capable of distinguishing VSD cases from controls (area under the ROC curve [AUC]: 0.997; p < 1.00E-05). Conclusion: Circulating exosomal miRNAs, particularly hsa-miR-146a-5p, may be predictive biomarkers for the non-invasive prenatal diagnosis of fetal VSDs. +circulation_biomarker_diagnosis_ns 34567065 hsa-mir-182 Diabetes Mellitus, Type 2 We therefore aimed to investigate the expressions of circulating miRNAs (miR-30a-5p, miR-1299, miR +lncRNA target 34566408 hsa-mir-214 Liver Neoplasms CONCLUSION: In this work, we determined that ketamine suppressed viability of liver cancer cells and induced ferroptosis and identified the possible regulatory mechanism of lncPVT1/miR +genetics_knock down_suppress 34565758 hsa-mir-26b Thyroid Cancer, Papillary Through dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay, microRNA-26b-5p (miR-26b-5p) was identified to be the intermediary molecular between circ_0079558 and MET, and circ_0079558 knockdown reduced the expression of MET partly through elevating miR-26b-5p in PTC cells. In conclusion, circ_0079558 facilitated the proliferation and motility whereas inhibited the apoptosis of PTC cells largely through mediating miR-26b-5p/MET/AKT signaling. +transcription factor target 34565303 hsa-mir-140 Cartilage Diseases 5p repressed chondrocyte pyroptosis and alleviated OA cartilage injury via inhibition of the CTSB/NLRP3. +transcription factor target 34565303 hsa-mir-140 Osteoarthritis 5p repressed chondrocyte pyroptosis and alleviated OA cartilage injury via inhibition of the CTSB/NLRP3. +circulation_biomarker_diagnosis_up 34565302 hsa-mir-378a Sepsis Serum miR-378a-3p was increased in sepsis patients and rat model. +circulation_biomarker_diagnosis_up 34565302 hsa-mir-378a Inflammation Serum miR-378a-3p was increased in sepsis patients and rat model. +other 34565286 hsa-mir-106b Carcinoma, Hepatocellular Further investigation suggested that LOC107985656 regulated the expression of LATS1 by acting as a sponge for absorbing miR-106b-5p in HCC cells. In conclusion, this study unraveled the role of LOC107985656 following a ceRNA (competing endogenous RNAs) mechanism for the miR-106b-5p/LATS1 axis in HCC. +genetics_overexpression_promote 34565284 hsa-mir-640 Carcinoma, Renal Cell Besides, miR-640 downregulation or NPTX2 overexpression partly overturned the tumor suppressor function of circ_0054537 silence and miR-640 overexpression in RCC cells. In conclusion, circ_0054537/miR-640/NPTX2 ceRNA pathway regulated RCC malignant progression in vitro and curbed RCC tumor growth in vivo, which could be a potential diagnosis and therapeutic target of RCC. +circRNA target 34565283 hsa-mir-488 Stomach Neoplasms From our results, we showed that hsa_circ_0000751 may serve as a miRNA sponge to suppress the activity of miR-488, thereby increasing the expression of the miRtarget gene, UQCRC2, and limiting GC progression. +genetics_overexpression_suppress 34565010 hsa-mir-363 Urinary Bladder Neoplasms In addition, overexpression of BTG2 reversed the inhibitory effect of miR +circulation_biomarker_diagnosis_ns 34565002 hsa-mir-103 Lung Neoplasms Serum levels of miR-103 and HDL were significantly enhanced in lung carcinoma patients achieving PR after chemotherapy (p<0.05). +lncRNA target 34565000 hsa-let-7a Carcinoma, Non-Small-Cell Lung Herein, we investigated the effects of let-7a targets Rsf-1 on modulating the radiotherapy response in NSCLC cells by Ras-MAPK pathway. The present study provides evidence that let-7a targeting Rsf-1 can modulate radiotherapy response in NSCLC cells through Ras-MAPK pathway. +circulation_biomarker_prognosis_ns 34564990 hsa-mir-509 Carcinoma, Hepatocellular RESULTS: qRT-PCR and starBase analysis showed that the miR-187 expression was low in the tissues and serum of primary HCC patients, while that of miR +other 34564949 hsa-mir-155 Alopecia Areata OBJECTIVES: We aimed at exploring the association between some miRNAs lesional expression and AA pathogenesis by measurement of miRNAs-155, 146a, and 203 expression levels in the lesional skin from patchy AA patients and to evaluate their relation with the studied parameters. SUBJECTS AND METHODS: Skin expression levels of miRNAs-155, 146a, and 203 were evaluated in 50 patients with patchy AA and 25 healthy controls using reverse transcriptase-quantitative PCR (RT-qPCR). +genetics_overexpression_promote 34564768 hsa-mir-497 Carcinoma, Hepatocellular 5p inhibitors and or HMGA2 overexpression partially counteracted the suppressing effect induced by si-circ-CCND1 on the malignant phenotype of HCC cells. +genetics_knock down_promote 34564700 hsa-mir-126 Leukemia, Myeloid, Chronic-Phase Spred1 KO, regardless if occurred in HSCs or in ECs, increased miR-126 in LSKs (Lin(-)Sca-1(+)c-Kit(+)), a population enriched in leukemic stem cells (LSCs), resulting in expansion of LSCs, likely through hyperactivation of the MAPK/ERK pathway that augmented Bcl-2 expression and stability. +other 34564643 hsa-mir-133a Cardiotoxicity No significant difference was observed in biomarkers of inflammation, oxidative stress, acute kidney injury (IL-18, CRP, ferritin, IMA, SOD, NGAL, and KIM-1), and miR-133a, in regards to the presence/absence of CV event, CV death, and left ventricular hypertrophy. +lncRNA target 34563560 hsa-mir-142 Post-Dural Puncture Headache However, which genes are targeted by miR +lncRNA target 34563560 hsa-mir-17 Post-Dural Puncture Headache However, which genes are targeted by miR +genetics_overexpression_promote 34563514 hsa-mir-125b Cardiomyopathies Overexpression of miR-125b mitigated myocardial dysfunction induced by CLP in vivo. +circulation_biomarker_diagnosis_ns 34563222 hsa-mir-410 Cancer-Associated Cachexia 3p was higher in subcutaneous adipose tissues and serum exosomes of CAC patients, which significantly inhibits adipogenesis and lipid accumulation. +circulation_biomarker_prognosis_up 34562827 hsa-mir-134 Stomach Neoplasms 5p in the cytoplasm of GC tissue cells. +genetics_GWAS 34562686 hsa-mir-200 Breast Neoplasms Thus, this study provides the initial foundation for using miR-200s for breast cancer prevention and additional studies should be performed to identify strategies for increasing mammary miR-200 expression and determine whether miR-200s can prevent mammary tumor initiation by other genetic alterations. +genetics_overexpression_promote 34562605 hsa-mir-335 Thyroid Cancer, Papillary 5p restoration inhibited proliferation, angiogenesis and radioresistance in PTC cells, while YAP1 overexpression abolished these effects. +circRNA target 34562344 hsa-mir-942 Uterine Cervical Neoplasms 5p was identified as a downstream target of circ_0000730, and circ_0000730 could positively regulate PTEN expression via repressing miR +lncRNA target 34562123 hsa-mir-650 Colorectal Neoplasms CONCLUSION: This study highlighted that MIR155HG, by regulating the miR-650/ANXA2 axis, promotes CRC progression and enhances oxaliplatin resistance in CRC cells through M2 macrophage polarization. +genetics_knock down_promote 34562091 hsa-mir-142 Retinoblastoma Cotransfection of PTEN overexpression plasmids reversed the influences of miR +lncRNA target 34561554 hsa-mir-183 Breast Neoplasms 5p and the efficacy of PLK1-specific inhibitors in breast cancer cells. +lncRNA target 34561425 hsa-mir-765 Esophageal Squamous Cell Carcinoma Our findings revealed a novel lncRNA RP11-465B22.8/miR-765/KLK4 pathway in EC and indicated that lncRNA RP11-465B22.8 might be a potential target for EC therapy. +lncRNA target 34560673 hsa-mir-204 Osteoarthritis induced stimulation of IL-1beta in human OASFs occurred via the suppression of miR +lncRNA target 34560556 hsa-mir-382 Colorectal Neoplasms 5p, and miR-15b-5p can substantially reduce tumor migration, inhibit tumor development, stimulate anti-tumoral immune responses, decrease tumor viability, and enhance the chemosensitivity of colorectal cancer cells regardless of the microsatellite state. +lncRNA target 34560556 hsa-mir-200a Colorectal Neoplasms 5p, and miR-15b-5p can substantially reduce tumor migration, inhibit tumor development, stimulate anti-tumoral immune responses, decrease tumor viability, and enhance the chemosensitivity of colorectal cancer cells regardless of the microsatellite state. +lncRNA target 34560556 hsa-mir-140 Colorectal Neoplasms 5p, and miR-15b-5p can substantially reduce tumor migration, inhibit tumor development, stimulate anti-tumoral immune responses, decrease tumor viability, and enhance the chemosensitivity of colorectal cancer cells regardless of the microsatellite state. +lncRNA target 34560556 hsa-mir-200c Colorectal Neoplasms 5p, and miR-15b-5p can substantially reduce tumor migration, inhibit tumor development, stimulate anti-tumoral immune responses, decrease tumor viability, and enhance the chemosensitivity of colorectal cancer cells regardless of the microsatellite state. +lncRNA target 34560556 hsa-mir-15b Colorectal Neoplasms 5p, and miR-15b-5p can substantially reduce tumor migration, inhibit tumor development, stimulate anti-tumoral immune responses, decrease tumor viability, and enhance the chemosensitivity of colorectal cancer cells regardless of the microsatellite state. +lncRNA target 34560556 hsa-mir-93 Colorectal Neoplasms 5p, and miR-15b-5p can substantially reduce tumor migration, inhibit tumor development, stimulate anti-tumoral immune responses, decrease tumor viability, and enhance the chemosensitivity of colorectal cancer cells regardless of the microsatellite state. +lncRNA target 34560556 hsa-mir-148a Colorectal Neoplasms 5p, and miR-15b-5p can substantially reduce tumor migration, inhibit tumor development, stimulate anti-tumoral immune responses, decrease tumor viability, and enhance the chemosensitivity of colorectal cancer cells regardless of the microsatellite state. +lncRNA target 34560556 hsa-mir-138 Colorectal Neoplasms 5p, and miR-15b-5p can substantially reduce tumor migration, inhibit tumor development, stimulate anti-tumoral immune responses, decrease tumor viability, and enhance the chemosensitivity of colorectal cancer cells regardless of the microsatellite state. +lncRNA target 34560189 hsa-mir-665 Glioma RNF144A-AS1 up-regulated the expression of HMGA1 by targeting miR-665, thereby promoting the development of glioma cells. +genetics_overexpression_promote 34559955 hsa-mir-103a Osteosarcoma More interestingly, miR-103a-3p depletion or SIK2 overexpression restored the impacts of down-regulated LINC00662 on OS cells. +lncRNA target 34559933 hsa-mir-199a Glioma Rescue experiments were conducted to explore the function of CDKN2B-AS1 and miR-199a-5p in glioma. CONCLUSION: Our study reveals that CDKN2B-AS1 promotes glioma development by regulating the miR-199a-5p/DDR1 axis, suggesting that this lncRNA might be a potential therapeutic target. +circRNA target 34559381 hsa-mir-1184 Breast Neoplasms In conclusion, we demonstrate that circ_0001598/miR-1184/PD-L1 signaling plays a crucial role in the regulation of BC progression and trastuzumab-resistance phonotypes, which suggests that circ_0001598 may be a molecular target to treat HER2-positive BC patients. +lncRNA target 34559207 hsa-mir-26b Osteoarthritis Cellular and molecular analyses showed that asporin can be inhibited by miR-26b-5p, which was significantly downregulated in OA cartilage, leading to exacerbation of experimental OA partially through inhibition of TGF-beta1-Smad2 signalling in chondrocytes. +genetics_overexpression_suppress 34559194 hsa-mir-23a Arthritis, Juvenile Despite enhanced reactive oxygen species (ROS) levels within the local inflammatory milieu, JIA T cells are hyperproliferative and reveal an overexpression of miR-23a, which is an inhibitor of Peptidyl-prolyl isomerase F (PPIF), the regulator of mitochondrial ROS escape. +lncRNA target 34558803 hsa-mir-29b Coronary Stenosis MIAT participated in the development of CAD via miR-29b-3p/PAPPA axis. +lncRNA target 34558803 hsa-mir-29b Coronary Artery Disease MIAT participated in the development of CAD via miR-29b-3p/PAPPA axis. +transcription factor target 34558654 hsa-mir-218 Glioma Our data revealed a previously unknown tumor suppressor role of miR218 by blocking the TNC/AKT/AP1/TGFbeta1positive feedback loop in glioma. +lncRNA target 34558643 hsa-mir-206 Carcinoma, Non-Small-Cell Lung PTMA is a target of miR206 and silencing CYTOR inhibited PTMA expression via miR206, thus promoting radiosensitivity of NSCLC cells. +lncRNA target 34558639 hsa-mir-383 Adenocarcinoma of Lung In the present study, an association between the downregulation of miR383 expression and the deletion of chr8p22 in patients with lung adenocarcinoma was identified. Taken together, the downregulation of miR383 induced RBM24 expression, which was mediated through the activation of NFkappaB signaling, to contribute to chemotherapy resistance in lung adenocarcinoma cells. +genetics_knock down_promote 34558634 hsa-mir-205 Rhinitis, Allergic In conclusion, the present findings suggested that miR2055p knockdown may attenuate the inflammatory response in AR by targeting BCL6, which may be a potential therapeutic target for AR. +other 34558538 hsa-mir-124 Brain Injuries, Traumatic These findings suggest that HOXA11-AS can aggravate neuroinflammation after traumatic brain injury by modulating the miR3p-MDK axis. +other 34558393 hsa-mir-224 Atherosclerosis The expression level of lncSNHG8 was increased in AS patients, while miR3p expression was decreased. +lncRNA target 34558385 hsa-mir-29c Pneumonia Disruption of MEG3 alleviated cell injury and inflammation as characterized by high LPS by binding miR-29 c. +circulation_biomarker_diagnosis_ns 34558328 hsa-mir-19a Carotid Stenosis Furthermore, the level of serum miR-19a-3p (hazard ratio [HR] = 8.507, 95% confidence interval [CI] = 2.239-32.328, P = .002) and degree of artery stenosis (HR = 3.695, 95% CI = 1.127-12.109, P = .031) were independent predictors of occurrence of CIE. +circulation_biomarker_diagnosis_ns 34558328 hsa-mir-19a Brain Ischemia Furthermore, the level of serum miR-19a-3p (hazard ratio [HR] = 8.507, 95% confidence interval [CI] = 2.239-32.328, P = .002) and degree of artery stenosis (HR = 3.695, 95% CI = 1.127-12.109, P = .031) were independent predictors of occurrence of CIE. +lncRNA target 34558284 hsa-mir-133b Heart Diseases These results indicate that an oil-induced increase in miR133b may contribute to cardiac abnormalities in oil-exposed fish by targeting cardiac-specific genes essential for proper heart development. +other 34558239 hsa-mir-16 Depression OBJECTIVE: To observe the effect of Mongolian medicine three-acupoints balance needling on the expression of p11/tPA/BDNF pathway and miRNA-16 in the hippocampus and middle raphe nucleus (MRN) in chronic stress depression model rats, so as to explore its mechanisms underlying improvement of depression. CONCLUSION: Mongolian medicine three-acupoints balance needling can improve the depressive state in depression rats, which may be associated with its effects in up-regulating the expression of p11 and tPA proteins and BDNF mRNA in the hippocampus and MRN and in down-regulating miRNA-16 in the hippocampus, suggesting an involvement of miRNA-16 controlled p11/tPA/BDNF signaling pathway in the antidepressant effect of acupuncture. +lncRNA target 34557649 hsa-mir-721 Alzheimer Disease 5p, and miR-721 - were predicted to display gene targets and important signaling pathways closely associated with AD pathogenesis and verified by ddPCR. +lncRNA target 34557649 hsa-mir-196b Alzheimer Disease 5p, and miR-721 - were predicted to display gene targets and important signaling pathways closely associated with AD pathogenesis and verified by ddPCR. +lncRNA target 34557649 hsa-mir-376b Alzheimer Disease 5p, and miR-721 - were predicted to display gene targets and important signaling pathways closely associated with AD pathogenesis and verified by ddPCR. +lncRNA target 34557649 hsa-mir-34a Alzheimer Disease 5p, and miR-721 - were predicted to display gene targets and important signaling pathways closely associated with AD pathogenesis and verified by ddPCR. +target gene 34557255 hsa-mir-635 Multiple Myeloma circ_0058063 expression increased in multiple myeloma tissues. Knocking down its expression may inhibit myeloma proliferation, migration, and invasion by targeting and upregulating miR-635 and also promote cell apoptosis. +other 34556996 hsa-mir-200c Pancreatic Neoplasms Carbon-Ion Beam Irradiation and the miR-200c Mimic Effectively Eradicate Pancreatic Cancer Stem Cells Under in vitro and in vivo Conditions. +exosome 34556984 hsa-mir-136 Carcinoma, Non-Small-Cell Lung 5p antagomir packaging into anlotinib-resistant NSCLC cell-derived exosomes functionally restored NSCLC cell anlotinib sensitivity in vitro. +genetics_knock down_suppress 34556632 hsa-mir-944 Stomach Neoplasms In vitro experiments demonstrated that circHAS2 knockdown or the addition of hsa-miR-944 mimics inhibited the proliferation, migration, and invasion ability of GC cells and affected the epithelial-mesenchymal transition. The circHAS2/hsa-miR-944/PPM1E axis may be involved in the progression of GC; thus, circHAS2 may be a potential biomarker and therapeutic target for GC. +exosome 34555810 hsa-mir-422a Ovarian Neoplasms CONCLUSIONS: Foxo3 promoted OC progression through exosome-mediated intercellular interaction to target miR-422a/PLP2 axis. +target gene 34555726 hsa-mir-520 Osteosarcoma Hsa_circ_0088212-mediated miR-520 h/APOA1 axis inhibits osteosarcoma progression. +virus_miRNA 34555439 ebv-mir-BART2 Stomach Neoplasms MiR-BART2-3p targets Unc-51-like kinase 1 and inhibits cell autophagy and migration in Epstein-Barr virus-associated gastric cancer +lncRNA target 34554926 hsa-mir-19b Intervertebral Disc Degeneration This research confirmed that miR-19b-3p suppressed HNPC apoptosis in the in-vitro model of IVDD by regulating PTEN/PI3K/Akt/mTOR pathway. +genetics_knock down_promote 34554678 hsa-mir-100 Ventricular Premature Complexes Moreover, we found that circ_0004104 could sponge miR-100 and a miR-100 inhibitor could reverse the inhibition effect of circ_0004104 knockdown on ox-LDL-induced VEC injury. +other 34554678 hsa-mir-100 Coronary Artery Disease Our results revealed that circ_0004104 was upregulated and miR-100 was downregulated in patients with CAD and ox-LDL-induced VECs. Our data suggested that circ_0004104 promoted ox-LDL-induced VEC injury by the miR-100/TNFAIP8 axis, indicating that circ_0004104 might be a potential biomarker for CAD treatment. +other 34554676 hsa-mir-30 Atherosclerosis Moreover, MALAT1 regulated NF-kappaB signal pathway to mediate the pathogenesis of AS by sponging miR5p. +lncRNA target 34554275 hsa-mir-142 Inflammation CONCLUSION: Upon MG infection, upregulation of gga-miR3p alleviates inflammation by negatively regulating the signaling pathways of NF-kappaB and MAPKs by targeting TAB2 and facilitates cell proliferation by inhibiting cell apoptosis and promoting cell cycle progression to defend against MG infection. +lncRNA target 34554275 hsa-mir-142 Myasthenia Gravis 3p alleviates inflammation by negatively regulating the signaling pathways of NF-kappaB and MAPKs by targeting TAB2 and facilitates cell proliferation by inhibiting cell apoptosis and promoting cell cycle progression to defend against MG infection. +other 34553694 hsa-mir-452 Colorectal Neoplasms These results suggest that MIR452 might directly or indirectly regulate the genes transcription related to CRC by downregulating GTF2E1 expression. +other 34553456 hsa-mir-133b Cardiomyopathies The current work reveals a unique role of the TUG1/miR-133b/CTGF axis in MF, thus suggesting its immense therapeutic potential in the treatment of cardiac diseases. +lncRNA target 34553450 hsa-mir-873 Myocardial Reperfusion Injury Retraction: Methyltransferase-like 3 (METTL3) attenuates cardiomyocyte apoptosis with myocardial ischemia-reperfusion (I/R) injury through miR +lncRNA target 34553078 hsa-mir-182 Diabetic Nephropathies CONCLUSION: Taken together, MIAT functioned as an inhibitory factor in the pathogenesis to impede the development of DN and inactivate the NF-kappaB pathway via regulating the miR5p/GPRC5A axis. +other 34553033 hsa-mir-137 Stomach Neoplasms lncRNA DSCR8 mediates miR-137/Cdc42 to regulate gastric cancer cell proliferation, invasion, and cell cycle as a competitive endogenous RNA. +transcription factor target 34553025 hsa-mir-519d Carcinoma, Non-Small-Cell Lung This showed that miR-519d-3p can be used as a diagnostic biomarker and target therapy for NSCLC. +lncRNA target 34553021 hsa-mir-10a Carcinoma, Renal Cell The MMP25-AS1/hsa-miR-10a-5p/SERPINE1 ceRNA network related to the prognosis of KIRC was obtained through bioinformatics analysis based on The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. +exosome 34552961 hsa-mir-26a Carcinoma, Hepatocellular Furthermore, anti-GPC3 scFv-modified exosomes effectively delivered miR-26a to GPC3-positive hepatocellular carcinoma cells, thereby inhibiting cell proliferation and migration by regulating the expression of downstream target genes of miR-26a. +other 34552925 hsa-mir-17 Stomach Neoplasms CONCLUSION: The study unveiled that the LncRNA NEAT1/miR5p/TGFbetaR2 axis is a novel mechanism in GC angiogenesis. +other 34552821 hsa-mir-21 Obesity Our findings suggest that miR-21 mimic-based therapy may provide a new opportunity to therapeutically manage obesity and consequently, its associated alterations. +lncRNA target 34552818 hsa-mir-149 Stomach Neoplasms 5p/CCDC6 axis might be developed as a therapeutic target and prognostic indicator for GC. +transcription factor target 34552061 hsa-mir-9 Breast Neoplasms The study proved that miR3p regulates biological functions, drug resistance, and the growth of Gem-treated breast cancer cells through targeting MTDH. +lncRNA target 34552050 hsa-mir-497 Pancreatic Carcinoma 5p acted as a tumour suppressor gene in pancreatic cancer by targeting HMGA2. +transcription factor target 34552038 hsa-mir-21 Brain Ischemia Our data uncover a novel mechanism of miR-21 in regulating cerebral ischemic neuronal injury by inhibiting p53/Bcl-2/Bax signaling pathway, which suggests that miR-21/p53 may be attractive therapeutic molecules for treatment of ischemic stroke. +genetics_knock down_promote 34551979 hsa-mir-210 succinic semialdehyde dehydrogenase deficiency In exploring mechanisms of SDH down-regulation in ccRCC, we report that Von Hippel-Lindau loss-induced hypoxia-inducible factor-dependent up-regulation of miR-210 causes direct inhibition of the SDHD transcript. +genetics_knock down_promote 34551979 hsa-mir-210 Carcinoma, Renal Cell In exploring mechanisms of SDH down-regulation in ccRCC, we report that Von Hippel-Lindau loss-induced hypoxia-inducible factor-dependent up-regulation of miR-210 causes direct inhibition of the SDHD transcript. +genetics_knock down_promote 34551785 hsa-mir-202 Pancreatic Carcinoma We then carried out gain- and loss-of function of miR +transcription factor target 34551709 hsa-mir-20 Osteoarthritis CONCLUSION: Suppression of CRLF1 promotes the chondrogenic differentiation of BMSCs and protects cartilage tissue from damage in osteoarthritis via activation of miR-320. +genetics_knock down_promote 34551673 hsa-mir-186 Uterine Cervical Neoplasms Knockdown of IGF1 reversed the results of miR +genetics_GWAS 34551209 hsa-mir-143 Coronary Artery Disease Whether SNPs within the genomic sequence of the miR-143/145 cluster are involved in cardiovascular disease development is not known. +genetics_GWAS 34551209 hsa-mir-145 Coronary Artery Disease Whether SNPs within the genomic sequence of the miR-143/145 cluster are involved in cardiovascular disease development is not known. +lncRNA target 34551195 hsa-mir-7 Lung Neoplasms The research suggests that the circ-WHSC1/miR-7/TAB2 axis might be a potential target for NSCLC therapy. +genetics_knock down_promote 34550549 hsa-mir-34a Stomach Neoplasms LINC01106 knockdown led to the suppression of cell invasion, migration, and viability, whereas these effects caused by LINC01106 knockdown were reversed by miR-34a-5p down-regulation or MYCN up-regulation in GC cells. +circulation_biomarker_diagnosis_down 34550352 hsa-mir-4446 Acromegaly CONCLUSIONS: In a 2-phase experiment using 2 different techniques we found and validated the downregulation of plasma miR +circulation_biomarker_diagnosis_down 34550352 hsa-mir-215 Acromegaly CONCLUSIONS: In a 2-phase experiment using 2 different techniques we found and validated the downregulation of plasma miR +lncRNA target 34549308 hsa-mir-125a Breast Neoplasms All these data suggested that miR125a5p reverses EMT and restores drug sensitivity by negatively regulating TAFAZZIN in breast cancer and, therefore, has potential as a novel therapeutic target for this disease. +lncRNA target 34548487 hsa-mir-194 Stomach Neoplasms Silencing KLF5 augmented GC cell autophagy, apoptosis and impeded its viability through the DANCR/miR-194/AKT2 axis. +genetics_overexpression_promote 34548334 hsa-mir-155 Lymphoma miRNA-155 (miR-155) is overexpressed in various types of lymphomas and leukemias, suggesting that targeting miR-155 could be a potential platform for the development of precision medicine. +transcription factor target 34547965 hsa-mir-130a Retinoblastoma CONCLUSIONS: miR-130a-3p enhanced the chemosensitivity of Y79 RB cells to VCR by targeting PAX6 expression. +circulation_biomarker_diagnosis_up 34547828 hsa-mir-628 Dermatitis, Atopic CONCLUSION: Our new findings suggest that the plasma miR +other 34547756 hsa-mir-378a Obesity RESULTS: miR-146a, miR-155, and miR-378a were upregulated in overweight mothers, while miR-378a was upregulated in obese mothers compared to normal weight mothers. In vitro exposure to high triglyceride and exposure to miR-378a induced a higher expression of PPAR-gamma in cells from offspring of mothers with overweight and obesity. +other 34547756 hsa-mir-378a Obesity, Maternal RESULTS: miR-146a, miR-155, and miR-378a were upregulated in overweight mothers, while miR-378a was upregulated in obese mothers compared to normal weight mothers. In vitro exposure to high triglyceride and exposure to miR-378a induced a higher expression of PPAR-gamma in cells from offspring of mothers with overweight and obesity. +lncRNA target 34547282 hsa-mir-802 Pancreatitis CONCLUSIONS: We show miR-802 suppresses pancreatic cancer initiation by repressing oncogenic Kras-induced ADM. +lncRNA target 34547245 hsa-mir-17 Vascular Diseases Overall, LIPUS irradiation prevents AngII-induced RAVSMCs phenotypic switching through hampering miR5p and enhancing PPAR-gamma, suggesting a new approach for the treatment of vascular disorders. +other 34547186 hsa-mir-16 Heart Diseases CONCLUSION: Our study is the first to report the abnormal expression of CAIF and miR-16 in heart disease. +circulation_biomarker_diagnosis_down 34547186 hsa-mir-16 Heart Failure RESULTS: The expression levels of CAIF and miR-16 were downregulated in the plasma of sepsis-induced CHF patients and were positively correlated in these patients. +circulation_biomarker_diagnosis_down 34547186 hsa-mir-16 Sepsis RESULTS: The expression levels of CAIF and miR-16 were downregulated in the plasma of sepsis-induced CHF patients and were positively correlated in these patients. +lncRNA target 34547172 hsa-mir-144 Heart Failure, Ischemic 3p/Nrf2 axis, which may be a new treatment target for renal I/R injury. +genetics_overexpression_promote 34547134 hsa-mir-221 Squamous Cell Carcinoma of Head and Neck RESULTS: SCIRT and GAS5 were downregulated, while miR-221 was overexpressed in OSCC. +exosome 34546854 hsa-mir-1224 Squamous Cell Carcinoma of Head and Neck To sum up, our study demonstrated that exosomal APCDD1L-AS1 conferred resistance to 5-FU in HSC-3/5-FU and HN-4/5-FU cells via the miR +genetics_knock down_promote 34546850 hsa-mir-153 Endometriosis 3p inhibition could abrogate the impacts of circPIP5K1A knockdown on EM progression in vitro. +other 34546840 hsa-mir-4649 Nasopharyngeal Carcinoma The results suggest that LINC02570 is upregulated in late clinical stage NPC patients, and promotes NPC progression by adsorbing miR3p to up-regulate SREBP1 and FASN. +circRNA target 34546569 hsa-mir-503 Uterine Cervical Neoplasms CircSAMD11 contributed to CC progression by regulating miR-503/SOX4 signalling and activating Wnt/beta-catenin pathway, which provides a promising therapeutic target for cervical cancer. +genetics_GWAS 34546460 hsa-mir-182 Hypertension, Pulmonary Both miR-182 and Myadm are expressed in the cardiopulmonary system and correlated with the balance between the bone morphogenetic protein (BMP) and the transforming growth factor (TGF)-beta signalling pathways, which are disturbed in PAH. +genetics_GWAS 34546460 hsa-mir-182 Diabetic Retinopathy Both miR-182 and Myadm are expressed in the cardiopulmonary system and correlated with the balance between the bone morphogenetic protein (BMP) and the transforming growth factor (TGF)-beta signalling pathways, which are disturbed in PAH. +genetics_overexpression_promote 34546403 hsa-mir-214 Liver Cirrhosis CONCLUSION: Hepatic overexpression of miR-214 is associated with progression of liver fibrosis in patients with BA, and the circulating miR-214 level may serve as a non-invasive predictor of liver fibrosis. +genetics_overexpression_promote 34546403 hsa-mir-214 Biliary Atresia CONCLUSION: Hepatic overexpression of miR-214 is associated with progression of liver fibrosis in patients with BA, and the circulating miR-214 level may serve as a non-invasive predictor of liver fibrosis. +genetics_knock down_suppress 34545676 hsa-mir-423 Diabetes Mellitus 5p knockdown in ADSCs ameliorated high glucose-mediated damage to HUVECs and improved erectile function in DM rats by inducing eNOS and VEGFa overexpression, indicating that miR +lncRNA target 34545623 hsa-mir-630 Osteosarcoma CONCLUSION: Circ-MTO1 and miR-630 expressions are inter-correlated and dysregulated in osteosarcoma patients. +lncRNA target 34544967 hsa-mir-1303 Cardiotoxicity In this study, we investigated the role and mechanism of circ-SKA3 in DOX-induced cardiotoxicity.The quantitative real-time polymerase chain reaction and western blot assays were applied to measure the expression of circ-SKA3, microRNA (miR) -1303, and toll-like receptor 4 (TLR4). Additionally, circ-SKA3 contributed to DOX-induced cardiotoxicity through the miR-1303/TLR4 axis. +exosome 34544909 hsa-mir-34c Infantile convulsions and paroxysmal choreoathetosis, familial M1 macrophages derived exosomes miR-34c-5p decreased ICCs cell viability by directly targeting SCF. +other 34544531 hsa-mir-455 Uterine Cervical Neoplasms 5p test by nano-PCR. +circulation_biomarker_diagnosis_up 34544412 hsa-mir-1180 Melanoma 3p in melanoma patient plasma is a promising diagnostic marker and provides novel insight into melanoma development. +circRNA target 34544313 hsa-mir-140 Osteoarthritis Circ_0128846 contributes to OA development through acting as a sponge RNA for miR +other 34543801 hsa-mir-100 Carcinoma, Pancreatic Ductal Finally, we observed that miR5p promoted Panc-1 and BxPC3 cell growth in vitro and in vivo. +genetics_knock down_promote 34543800 hsa-mir-200c Thyroid Cancer, Papillary Whilst overexpression of miR-200c was demonstrated to promote the proliferation, migration, and invasion of PTC cells; knockdown of miR-200c showed an opposite inhibitory effect. +lncRNA target 34543777 hsa-let-7i Carcinoma, Non-Small-Cell Lung RESULTS: DICER was highly expressed in DDP-resistant NSCLC tissues and cells, and DICER could target and negatively regulate the expression of let-7i-5p. CONCLUSION: Our research suggests that DICER promotes autophagy and DDP resistance in NSCLC through downregulating let-7i-5p, and inhibits the activation of PI3K/AKT/mTOR pathway. +transcription factor target 34543287 hsa-mir-155 Colitis Our findings indicate that chronic colitis impairs heart function through an IL-1beta-->miR>BDNF signaling axis. +other 34543233 hsa-mir-29b Parkinson Disease Conclusively, miR-29b2/c is involved in the regulation of aging and plays a detrimental role in Parkinson's disease. +transcription factor target 34542842 hsa-mir-29a Osteoarthritis miR-29a-3p is predicted to be a critical target for inhibiting insulin-like growth factor-1 expression and may aggravate the progression of OA. +lncRNA target 34542739 hsa-mir-511 Stomach Neoplasms Our research suggested that tumor-suppressive function of miR +circulation_biomarker_diagnosis_up 34542403 hsa-mir-181a Muscular Atrophy, Spinal RESULTS: Over 100 miRs were differentially expressed in SMA muscle; 3 of them (hsa-miR-181a-5p, 5p, -451a; SMA-miRs) were significantly upregulated in the serum of patients. +other 34542165 hsa-mir-424 Melanoma Collectively, the findings of the present study suggested that TINCR may attenuate the progression of CMM by regulating the miR4245p/LATS1 signaling axis. +other 34542164 hsa-mir-335 Myocardial Injury In conclusion, the upregulation of miR335 exerted ameliorative effects on myocardial injury following sepsis and may indicate a novel therapeutic intervention for SIMI. +other 34542164 hsa-mir-335 Cardiomyopathies In conclusion, the upregulation of miR335 exerted ameliorative effects on myocardial injury following sepsis and may indicate a novel therapeutic intervention for SIMI. +genetics_knock down_promote 34542161 hsa-mir-495 Urinary Bladder Neoplasms Moreover, circBIRC6 knockdown notably attenuated the proliferation, invasion, migration and EMT of BC cells, which was blocked by the miR4953p inhibitor. In conclusion, these findings demonstrated that circBIRC6 knockdown suppressed BC tumorigenesis and progression via regulation of the miR4953p/XBP1 signaling axis, offering a promising therapeutic target for the treatment of BC. +lncRNA target 34542064 hsa-mir-144 Colonic Neoplasms CONCLUSION: In summary, this study reveals critical roles and molecular mechanisms of the HCG11-mediated 5-FU resistance through modulating the miR +lncRNA target 34542062 hsa-mir-205 Squamous Cell Carcinoma of Head and Neck 5p were determined via quantitative real-time-PCR in fresh frozen tissues of 26 p16-positive, 19 p16-negative OPSCCs and 18 HPV-negative oropharyngeal controls. +other 34542062 hsa-mir-182 Squamous Cell Carcinoma of Head and Neck 5p in p16-positive and p16-negative oropharyngeal squamous cell carcinomas (OPSCCs). +other 34541816 hsa-mir-221 Atherosclerosis miR-221 was highly expressed while SIRT1 was poorly expressed in AS. In conclusion, LincRNA-p21 acted as a molecular sponge for miR-221 to promote deacetylation of the promoter region of Pcsk9 by SIRT1, therefore preventing the development of AS. +genetics_knock down_promote 34541682 hsa-mir-506 Ovarian Neoplasms 3p overexpression suppressed PTX resistance and malignant behaviors of PTX-resistant OC cells, with NFIB elevation rescued the impacts. +tissue_expression_ns 34541347 hsa-mir-1307 Urinary Bladder Neoplasms We evaluated the expression levels of miR3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, biliary tract cancer, brain cancer, sarcoma) and 27 non-cancer samples using isothermal amplification and microRNA chip. +tissue_expression_ns 34541347 hsa-mir-1307 Pancreatic Carcinoma We evaluated the expression levels of miR3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, biliary tract cancer, brain cancer, sarcoma) and 27 non-cancer samples using isothermal amplification and microRNA chip. +tissue_expression_ns 34541347 hsa-mir-1307 Sarcoma We evaluated the expression levels of miR3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, biliary tract cancer, brain cancer, sarcoma) and 27 non-cancer samples using isothermal amplification and microRNA chip. +tissue_expression_ns 34541347 hsa-mir-1307 Ovarian Neoplasms We evaluated the expression levels of miR3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, biliary tract cancer, brain cancer, sarcoma) and 27 non-cancer samples using isothermal amplification and microRNA chip. +tissue_expression_ns 34541347 hsa-mir-1307 Biliary Tract Neoplasms We evaluated the expression levels of miR3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, biliary tract cancer, brain cancer, sarcoma) and 27 non-cancer samples using isothermal amplification and microRNA chip. +tissue_expression_ns 34541347 hsa-mir-1307 Colonic Neoplasms We evaluated the expression levels of miR3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, biliary tract cancer, brain cancer, sarcoma) and 27 non-cancer samples using isothermal amplification and microRNA chip. +tissue_expression_ns 34541347 hsa-mir-1307 Esophageal Neoplasms We evaluated the expression levels of miR3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, biliary tract cancer, brain cancer, sarcoma) and 27 non-cancer samples using isothermal amplification and microRNA chip. +tissue_expression_ns 34541347 hsa-mir-1307 Prostatic Neoplasms We evaluated the expression levels of miR3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, biliary tract cancer, brain cancer, sarcoma) and 27 non-cancer samples using isothermal amplification and microRNA chip. +tissue_expression_ns 34541347 hsa-mir-1307 Liver Neoplasms We evaluated the expression levels of miR3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, biliary tract cancer, brain cancer, sarcoma) and 27 non-cancer samples using isothermal amplification and microRNA chip. +tissue_expression_ns 34541347 hsa-mir-1307 Brain Neoplasms We evaluated the expression levels of miR3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, biliary tract cancer, brain cancer, sarcoma) and 27 non-cancer samples using isothermal amplification and microRNA chip. +tissue_expression_ns 34541347 hsa-mir-1307 Lung Neoplasms We evaluated the expression levels of miR3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, biliary tract cancer, brain cancer, sarcoma) and 27 non-cancer samples using isothermal amplification and microRNA chip. +tissue_expression_ns 34541347 hsa-mir-1307 Breast Neoplasms We evaluated the expression levels of miR3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, biliary tract cancer, brain cancer, sarcoma) and 27 non-cancer samples using isothermal amplification and microRNA chip. +tissue_expression_ns 34541347 hsa-mir-1307 hereditary diffuse gastric cancer We evaluated the expression levels of miR3p in sera obtained from 254 patients with thirteen types of cancer (colon cancer, lung cancer, gastric cancer, liver cancer, bladder cancer esophageal cancer, breast cancer, ovarian cancer, prostate cancer, pancreatic cancer, biliary tract cancer, brain cancer, sarcoma) and 27 non-cancer samples using isothermal amplification and microRNA chip. +circulation_biomarker_diagnosis_ns 34540908 hsa-mir-29b Atrial Fibrillation Results: Elevated levels of TUG1 and low expression of miR-29b-3p were detected in the serum of AF patients compared with the healthy controls. Pearson's correlation analysis exhibited an inverse relationship between TUG1 and miR-29b-3p expression in AF patients (r = -7.106, p < 0.001). +circulation_biomarker_prognosis_up 34540745 hsa-mir-221 Depression, Postpartum 3p in serum and CSF can be used as the diagnostic and risk warning indicators of PSD. +genetics_overexpression_promote 34540669 hsa-mir-122 Rectal Neoplasms Besides, overexpression of miR +genetics_overexpression_promote 34540669 hsa-mir-142 Rectal Neoplasms Besides, overexpression of miR +lncRNA target 34540665 hsa-mir-1236 Colonic Neoplasms 3p functions as a tumor suppressor in colon cancer by targeting DCLK3 and is therefore a promising therapeutic target for colon cancer. +other 34540610 hsa-mir-26b Capsule Opacification RESULTS: The expression levels of miR-26b were significantly reduced in human posterior capsular opacification-attached lens tissue and TGF-beta2-stimulated HLE-B3 cells. +other 34540103 hsa-mir-153 Uterine Cervical Neoplasms Significantly lower levels of miR-153 and miR-203 were found in patients with myometrial infiltration, FIGO III-IV stage, and lymphatic metastasis (P<0.05). +other 34540103 hsa-mir-203 Uterine Cervical Neoplasms CONCLUSION: The expressions of miR-152 and miR-203 are down-regulated in patients with CC, which has diagnostic value for CC. +other 34540088 hsa-mir-92a Colonic Neoplasms CONCLUSION: Abnormally high expression of miR-92a occurs in colon tumor tissues. +circulation_biomarker_diagnosis_ns 34540082 hsa-mir-214 Osteoarthritis, Knee PURPOSE: To explore the effect of Etoricoxib on serum miR-214 expression level and inflammatory reaction in patients with knee osteoarthritis. +other 34540060 hsa-mir-506 Leukemia, Myelogenous, Chronic, BCR-ABL Positive miR-506 is evidently reduced in CML, and may be applied as a diagnostic and predictive treatment for CML and 5-year related survival +circulation_biomarker_prognosis_up 34540055 hsa-mir-192 Colonic Neoplasms The present study analyzed serum miR +circulation_biomarker_diagnosis_ns 34540038 hsa-mir-205 Chronic Periodontitis An ROC curve analysis showed that the areas under the curve (AUCs) of the serum miR-205 and HMGB1 expressions in diagnosing PO were 0.936 and 0.955 respectively. +lncRNA target 34540003 hsa-mir-106b late onset Parkinson's disease CONCLUSION: LncRNA PART1 could alleviate the damage effects of MPP(+) on SH-SY5Y cells by regulating microRNA-106b-5p/MCL1 axis, suggesting the potential therapeutic value of LncRNA PART1 as a target in PD. +other 34540002 hsa-mir-27a Alzheimer Disease LncRNA NEAT1 promotes Alzheimer's disease by down regulating micro-27a-3p. +lncRNA target 34539997 hsa-mir-32 Diabetes Mellitus 3p, thus inhibiting PCOS and diabetes progression. +lncRNA target 34539997 hsa-mir-32 Polycystic Ovary Syndrome 3p, thus inhibiting PCOS and diabetes progression. +circulation_biomarker_diagnosis_up 34539994 hsa-mir-579 Multiple Myeloma 3p-inhibitor plasmids compared with the blank group (P>0.050). +transcription factor target 34539990 hsa-mir-590 Osteoarthritis CONCLUSIONS: miR5p promotes OA progression by targeting FGF18, which serves as a potential therapeutic target for OA. +circRNA target 34539989 hsa-mir-622 Anodontia CircUBXN7 suppressed cell apoptosis and inflammatory reaction induced by H/R via targeting miR-622. CONCLUSION: CircUBXN7 mitigates cardiomyocyte apoptosis and inflammatory reaction in H/R injury by targeting miR-622 and maintaining MCL1 expression. +target gene 34539985 hsa-mir-761 Carcinoma, Non-Small-Cell Lung LncRNA TPTEP1 inhibited the proliferation and metastasis of non-small cell lung cancer cells by targeting miR-761/LATS2 axis. +other 34539984 hsa-mir-206 Stomach Neoplasms FAM225A-miR-206-ADAM12 axis may be a potential pathway for regulating gastric cancer. +target gene 34539888 hsa-mir-365a Colorectal Neoplasms Inhibition of the cell migration, invasion and chemoresistance of colorectal cancer cells through targeting KLF3 by miR-365a-3p. +target gene 34539887 hsa-mir-133a Colorectal Neoplasms FOXD3-induced miR-133a blocks progression and metastasis of colorectal cancer through regulating UBA2. +target gene 34539882 hsa-mir-552 Uterine Cervical Neoplasms miR-552 promotes the proliferation and metastasis of cervical cancer cells through targeting MUC15 pathway. +lncRNA target 34539879 hsa-mir-455 Cholangiocarcinoma Inhibition of miR +other 34539877 hsa-mir-23a Hepatoblastoma Conclusion: We concluded that SNHG9/miR-23a-5p/Wnt3a axis promotes the progression hepatoblastoma tumor. +lncRNA target 34539867 hsa-mir-545 Osteosarcoma 5p functions as a tumor suppressor in osteosarcoma that promotes apoptosis, while inhibiting migration and invasion by targeting DIMT1. +genetics_overexpression_promote 34539866 hsa-mir-1 Endometrial Neoplasms Furthermore, circ_POLA2 overexpression also increased EC cell proliferation, while miR-31 overexpression decreased cell proliferation. +genetics_knock down_promote 34539861 hsa-mir-149 Osteosarcoma Knockdown of lncRNA C5orf66-AS1 inhibits osteosarcoma cell proliferation and invasion via miR-149-5p upregulation. +other 34539857 hsa-mir-630 Lymphoma, Large B-Cell, Diffuse 5p) exhibited low expression levels in DLBCL (P<0.05), while miR-630 was highly expressed in DLBCL (P<0.05). +other 34539857 hsa-mir-19b Lymphoma, Large B-Cell, Diffuse 5p) exhibited low expression levels in DLBCL (P<0.05), while miR-630 was highly expressed in DLBCL (P<0.05). +other 34539857 hsa-mir-370 Lymphoma, Large B-Cell, Diffuse 5p) exhibited low expression levels in DLBCL (P<0.05), while miR-630 was highly expressed in DLBCL (P<0.05). +other 34539857 hsa-mir-193a Lymphoma, Large B-Cell, Diffuse 5p) exhibited low expression levels in DLBCL (P<0.05), while miR-630 was highly expressed in DLBCL (P<0.05). +other 34539857 hsa-mir-490 Lymphoma, Large B-Cell, Diffuse 5p) exhibited low expression levels in DLBCL (P<0.05), while miR-630 was highly expressed in DLBCL (P<0.05). +other 34539857 hsa-mir-665 Lymphoma, Large B-Cell, Diffuse 5p, miR-630 and miR-665) using DLBCL and LRH fresh samples. +target gene 34539856 hsa-mir-382 Osteosarcoma MicroRNA-382-5p inhibits osteosarcoma development and progression by negatively regulating VEZF1 expression. +lncRNA target 34539855 hsa-mir-143 Carcinoma, Non-Small-Cell Lung 3p in LUSC, and thus may become a potential prognostic marker and therapeutic target for the treatment of LUSC in the future. +transcription factor target 34539847 hsa-mir-139 Endometriosis 5p may play a key role in the progression of endometriosis by regulating the viability of ESCs and directly targeting BBC3. +target gene 34539845 hsa-mir-140 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Salidroside inhibits chronic myeloid leukemia cell proliferation and induces apoptosis by regulating the miR-140-5p/wnt5a/β-catenin axis. +other 34539843 hsa-mir-424 Osteoarthritis In summary, the findings indicated that LINC00473 contributed to OA progression by modulating the miR5p/LY6E axis, which may serve as a potential therapeutic strategy for patients with OA. +genetics_knock down_suppress 34539840 hsa-mir-140 Osteoarthritis LINC01385 knockdown reduced the progression of OA by modulating the miR +genetics_knock down_suppress 34539833 hsa-mir-155 Ovarian Neoplasms 5p inhibition or TYRP1 overexpression markedly reversed the inhibitory effects of miR155HG knockdown on OC cell viability, migration and invasion as well as weakened the promotive effect of miR155HG knockdown on OC cell apoptosis. +lncRNA target 34539825 hsa-mir-138 Asthma The TUG1/miR5p/E2F3 regulatory axis appeared to play a critical role in accelerating the viability and migration of ASMCs and may therefore have a role in asthma. +target gene 34539824 hsa-mir-532 Uterine Cervical Neoplasms LINC01094 promotes the invasion of ovarian cancer cells and regulates the Wnt/β-catenin signaling pathway by targeting miR-532-3p. +genetics_overexpression_promote 34539823 hsa-mir-27a Arthritis, Rheumatoid Silencing TLR5 in RASFs may exert similar effects to miR-27a-3p-overexpression; whereas, restoring TLR5 counteracted the suppression of miR-27a-3p-overexpression on RASF proliferation and inflammation, as well as the promotion on apoptosis. miR-27a-3p upregulation may suppress RA progression by inhibiting RASFs proliferation and inflammation through targeting TLR5. +circRNA target 34539405 hsa-mir-4778 Arthritis, Rheumatoid The level of the miRNA target of circ_0005198, miR +circulation_biomarker_diagnosis_ns 34539341 hsa-let-7g Ischemic Stroke These data suggest that circulating mml-let-7g may serve as a therapeutic target for ischemic stroke. +genetics_overexpression_promote 34538046 hsa-mir-877 Prostatic Neoplasms 5p, while overexpression of SSFA2 could abrogate the anti-tumor effects of miR +other 34537908 hsa-mir-17 dystonia 5 These findings indicate that PDE can activate GR in fetal rat ovary and induce DOR of offspring, and its heritability is mediated by the cascade effect of miR5p/FOXL2/CDKN1B. +transcription factor target 34537818 hsa-mir-2337 Infertility Taken together, our findings identify miR-2337 as an endogenous small activating RNA (saRNA) of TGF-beta1 in GCs, while miR-2337 is identified as a small activator of the TGF-beta signaling pathway which is expected to be a new target for rescuing GC apoptosis and treating low fertility. +other 34537762 hsa-mir-22 Multiple Sclerosis Patients with SPMS have a significantly higher miRNA-22 level than patients with RRMS. +genetics_overexpression_suppress 34537760 hsa-mir-320d Prostatic Neoplasms Further, a recovery experiment was used to confirm that miR-320d inhibited the progression of prostate cancer. KIF3C was overexpressed in prostate cancer, promoting its growth migration and invasion was induced by miR-320d/METTL3 in an m6A dependent process. +circRNA target 34537436 hsa-mir-4726 Intervertebral Disc Degeneration The tension-sensitive circRNA_0022382 was decreased, and we found that circRNA_0022382 promoted morphology of endplate chondrocytes by sponge-binding miR5p down-regulation of target gene the TGF-beta3 expression, thereby alleviating IDD. +exosome 34537206 hsa-mir-17 Carcinoma, Non-Small-Cell Lung We found that exosomal miR +genetics_overexpression_promote 34537072 hsa-mir-493 Carcinoma, Non-Small-Cell Lung Overexpression of miR +circulation_biomarker_diagnosis_up 34537058 hsa-mir-135 Stomach Neoplasms CONCLUSION: There are high expression levels of serum miR-135 and miR-20a in patients with GC. +circulation_biomarker_diagnosis_up 34537058 hsa-mir-20a Stomach Neoplasms CONCLUSION: There are high expression levels of serum miR-135 and miR-20a in patients with GC. +lncRNA target 34536977 hsa-mir-515 Glioblastoma CONCLUSION: LncRNA DLGAP1-AS1 accelerated cell proliferation in GBM via targeting miR +circulation_biomarker_diagnosis_ns 34536749 hsa-mir-125b Myelodysplastic Syndromes We apply the assay to the detection of miRNAs related to myelodysplastic syndromes (miR-125b, miR-16) in blood plasma and demonstrate that the assay enables detection of miR-125b with a limit of detection (LOD) of 349 aM (corresponding to the lowest detectable amounts of 419 zmol). +circulation_biomarker_diagnosis_ns 34536749 hsa-mir-16 Myelodysplastic Syndromes We apply the assay to the detection of miRNAs related to myelodysplastic syndromes (miR-125b, miR-16) in blood plasma and demonstrate that the assay enables detection of miR-125b with a limit of detection (LOD) of 349 aM (corresponding to the lowest detectable amounts of 419 zmol). +exosome 34536574 hsa-mir-149 Lissencephaly CONCLUSION: Exosome-mediated transfer of circ_0001846 modulated IL-1beta-induced chondrocyte cell damage by miR +exosome 34536574 hsa-mir-149 Osteoarthritis CONCLUSION: Exosome-mediated transfer of circ_0001846 modulated IL-1beta-induced chondrocyte cell damage by miR +other 34536542 hsa-mir-181a Myocardial Ischemia In addition, treatment with 5-Aza enhanced ischemia and reperfusion-induced cardiac dysfunction and injury in adults as compared with the saline controls, which was associated with up-regulations of miRNA-181a and angiotensin II receptor type 1 & 2 gene expressions, but down-regulations of PKCepsilon, Atg5, and GSK3beta gene expressions in left ventricles. +genetics_overexpression_suppress 34536429 hsa-mir-132 Alzheimer Disease Lentiviral-mediated inhibition or overexpression of miR +other 34536193 hsa-mir-182 Paraganglioma RESULTS: Our computational analysis identified four candidate miRNAs that showed elevated expression in metastatic compared to non-metastatic PCPGs: miR-182, miR-183, miR-96, and miR-383. Finally, using univariate and multivariate analysis, we found miRNA miR-182 to be an independent predictor of metastasis-free survival in PCPGs. +other 34536193 hsa-mir-182 Pheochromocytoma RESULTS: Our computational analysis identified four candidate miRNAs that showed elevated expression in metastatic compared to non-metastatic PCPGs: miR-182, miR-183, miR-96, and miR-383. Finally, using univariate and multivariate analysis, we found miRNA miR-182 to be an independent predictor of metastasis-free survival in PCPGs. +circulation_biomarker_prognosis_up 34535770 hsa-mir-151a Stomach Neoplasms sEV-miR-151a-3p is highly expressed in GC-LM patients' plasma and presents poor prognosis. +circulation_biomarker_diagnosis_ns 34535708 hsa-mir-16 Head and Neck Neoplasms Additionally, microRNAs known to interfere with dendritic cell function, and detected in EVs, matched microRNAs from squamous cell carcinoma patients' plasma: miR5p in oropharyngeal squamous cell carcinoma, miR-21 in oral squamous cell carcinoma, miR-16, miR-24, and miR-181a circulating in both oral and oropharyngeal squamous cell carcinoma, and miR-23b, which has not been previously described in plasma of head and neck squamous cell carcinoma, was found in plasma from patients with these cancer subtypes. +circulation_biomarker_diagnosis_ns 34535708 hsa-mir-17 Head and Neck Neoplasms Additionally, microRNAs known to interfere with dendritic cell function, and detected in EVs, matched microRNAs from squamous cell carcinoma patients' plasma: miR5p in oropharyngeal squamous cell carcinoma, miR-21 in oral squamous cell carcinoma, miR-16, miR-24, and miR-181a circulating in both oral and oropharyngeal squamous cell carcinoma, and miR-23b, which has not been previously described in plasma of head and neck squamous cell carcinoma, was found in plasma from patients with these cancer subtypes. +circulation_biomarker_diagnosis_ns 34535708 hsa-mir-24 Head and Neck Neoplasms Additionally, microRNAs known to interfere with dendritic cell function, and detected in EVs, matched microRNAs from squamous cell carcinoma patients' plasma: miR5p in oropharyngeal squamous cell carcinoma, miR-21 in oral squamous cell carcinoma, miR-16, miR-24, and miR-181a circulating in both oral and oropharyngeal squamous cell carcinoma, and miR-23b, which has not been previously described in plasma of head and neck squamous cell carcinoma, was found in plasma from patients with these cancer subtypes. +circulation_biomarker_diagnosis_ns 34535708 hsa-mir-21 Head and Neck Neoplasms Additionally, microRNAs known to interfere with dendritic cell function, and detected in EVs, matched microRNAs from squamous cell carcinoma patients' plasma: miR5p in oropharyngeal squamous cell carcinoma, miR-21 in oral squamous cell carcinoma, miR-16, miR-24, and miR-181a circulating in both oral and oropharyngeal squamous cell carcinoma, and miR-23b, which has not been previously described in plasma of head and neck squamous cell carcinoma, was found in plasma from patients with these cancer subtypes. +circulation_biomarker_diagnosis_ns 34535708 hsa-mir-23b Head and Neck Neoplasms Additionally, microRNAs known to interfere with dendritic cell function, and detected in EVs, matched microRNAs from squamous cell carcinoma patients' plasma: miR5p in oropharyngeal squamous cell carcinoma, miR-21 in oral squamous cell carcinoma, miR-16, miR-24, and miR-181a circulating in both oral and oropharyngeal squamous cell carcinoma, and miR-23b, which has not been previously described in plasma of head and neck squamous cell carcinoma, was found in plasma from patients with these cancer subtypes. +circulation_biomarker_diagnosis_ns 34535708 hsa-mir-181a Head and Neck Neoplasms Additionally, microRNAs known to interfere with dendritic cell function, and detected in EVs, matched microRNAs from squamous cell carcinoma patients' plasma: miR5p in oropharyngeal squamous cell carcinoma, miR-21 in oral squamous cell carcinoma, miR-16, miR-24, and miR-181a circulating in both oral and oropharyngeal squamous cell carcinoma, and miR-23b, which has not been previously described in plasma of head and neck squamous cell carcinoma, was found in plasma from patients with these cancer subtypes. +genetics_overexpression_promote 34535152 hsa-mir-485 Colorectal Neoplasms 5p overexpression suppressed CRC cell proliferation, migration, and invasion and facilitated apoptosis. +other 34535085 hsa-mir-1278 Nephritis CONCLUSIONS: The study indicates that circ_0007059 protects RMCs against apoptosis and inflammation during nephritis by attenuating miR-1278/SHP-1/STAT3 signaling. +circRNA target 34533810 hsa-mir-148b Carcinoma, Basal Cell, Skin CONCLUSIONS: Circ_NCKAP1 can promote skin BCC progression by sponging the miR-148b-5p/HSP90 axis, and circ_NCKAP1 may be a potential target for skin BCC therapy. +genetics_overexpression_promote 34533429 hsa-mir-132 Acute Lung Injury Moreover, overexpression of miR +other 34533283 hsa-mir-132 Cardiac Complexes, Premature We further demonstrated PSyC was mediated by EVs containing miR-132. +lncRNA target 34533201 hsa-mir-378a Esophageal Squamous Cell Carcinoma Taken together, these findings suggest that LINC00514 may participate in ESCC lipogenesis, and targeting the LINC00514/miR378a5p/SPHK1 signaling axis may be a novel and promising therapeutic strategy for management of patients with ESCC. +transcription factor target 34533066 hsa-mir-128 Carcinoma, Non-Small-Cell Lung Conclusion:miR3p inhibited the progression of NSCLC through targeting SKA3. +genetics_overexpression_promote 34533029 hsa-mir-10a Colonic Neoplasms The conditioned medium (CM) from LX-2 cells with miR-10a-5p overexpression or HLNFs could inhibit the invasion, migration, and stemness of CC SW480 cells, whereas HLCFs CM could promote these malignant phenotypes of SW480 cells. +circulation_biomarker_diagnosis_up 34533019 hsa-mir-379 Muscular Dystrophy, Duchenne We identified the upregulation of miR-379 in the serum and muscles of DMD animal models and patients. +circulation_biomarker_diagnosis_up 34533019 hsa-mir-379 Diabetic Nephropathies We identified the upregulation of miR-379 in the serum and muscles of DMD animal models and patients. +lncRNA target 34532814 hsa-mir-423 Diabetic Nephropathies Taken together, XIST depletion suppressed proliferation and promoted apoptosis via miR +genetics_overexpression_promote 34532813 hsa-mir-432 Osteosarcoma Circ_0000376 overexpression-mediated protective effects in Tan I-induced OS cells were partly attenuated by the accumulation of miR +lncRNA target 34532486 hsa-mir-93 Sciatic Neuropathy 5p can be used as potential targets for the diagnosis and treatment of sciatic nerve injury. +circRNA target 34532485 hsa-mir-515 Polycystic Ovary Syndrome CONCLUSIONS: circRHBG inhibits ferroptosis in PCOS cells through the circRHBG/miR5p/SLC7A11 axis in PCOS, which may provide new diagnostic molecular markers and therapeutic targets for PCOS. +other 34532478 hsa-mir-1238 Colorectal Neoplasms MMP1/MMP2/MMP9 axis in the growth and metastasis of CRC, which is crucial for the monitoring and treatment of CRC. +exosome 34532460 hsa-mir-21 Myocardial Reperfusion Injury CONCLUSIONS: MSC-EXOs promote the polarization of macrophages to the M2 phenotype via miR +lncRNA target 34532436 hsa-mir-146a Acute Lung Injury Together, in vivo and in vitro results demonstrated that CHRF enhanced sepsis-induced ALI by targeting miR-146a and up-regulating Notch1. +transcription factor target 34532435 hsa-mir-218 Adenocarcinoma of Lung CONCLUSIONS: miR-218 may negatively regulate FANCI, and FANCI could promote metastasis via extracellular matrix (ECM) receptor interaction, leading to poor prognosis of LUAD. +genetics_overexpression_suppress 34532392 hsa-mir-1278 Carcinoma, Non-Small-Cell Lung Overexpression of circ_0015278 attenuated the malignant phenotypes of NSCLC through sponging miR-1278 and consequently promoting SOCS6 expression. +circRNA target 34532379 hsa-mir-361 Osteosarcoma CONCLUSIONS: hsa_circ_0000006 is associated with the progression and development of OS through miR +lncRNA target 34532373 hsa-mir-197 Triple Negative Breast Neoplasms A mimic and an inhibitor of miR +other 34532322 hsa-mir-4732 Myocardial Infarction Overall, these results indicate that miR3p is regulated by hypoxia and exerts cardioprotective actions against ischemic insult, with potential application in cell-free-based therapeutic strategies. +circulation_biomarker_prognosis_up 34532291 hsa-mir-199b Stomach Neoplasms The expression of miR-199b-5p in GC cells and patients' plasma was detected by RT-PCR. +lncRNA target 34532283 hsa-mir-9 Glioma 5p directly targets ABCC1 and may make glioma cells sensitive to TMZ. +genetics_knock down_promote 34532282 hsa-mir-4435-2 Stomach Neoplasms The knockout of MIR4435-2HG could repress the proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) and accelerate the apoptosis of gastric carcinoma cells. +genetics_overexpression_promote 34532130 hsa-mir-744 Carcinoma, Hepatocellular Further, the overexpression of TGF-beta1 appeared to abolish the inhibitive effect of miR +lncRNA target 34532100 hsa-mir-204 Stomach Neoplasms In addition, circNOP10 sponged microRNA-24 (miR-204)-mediated biological processes through sirtuin 1 (SIRT1), which further confirmed that the circNOP10/miR-204/SIRT1 pathway promoted proliferation and migration as well as epithelial-mesenchymal transition (EMT) through the NF-kappabeta pathway in GC cell lines. CONCLUSIONS: Candidate oncogene circNOP10 mediated GC cell proliferation, arrest cell cycle in G(2)/M phase, induced cell apoptosis, enhanced tumor metastasis, as well as EMT by activating the miR-204/SIRT1 pathway, suggesting that it may serve as a potential biomarker in GC therapy. +transcription factor target 34532027 hsa-mir-140 Diabetes Mellitus Dan improved diabetes mellitus-induced renal injury via regulation of miR5p/TLR4 axis in in vitro and in vivo study. +transcription factor target 34532027 hsa-mir-140 Kidney Diseases Dan improved diabetes mellitus-induced renal injury via regulation of miR5p/TLR4 axis in in vitro and in vivo study. +target gene 34531986 hsa-mir-1254 Uterine Cervical Neoplasms lncRNA FEZF1-AS1 regulates biological behaviors of cervical cancer by targeting miRNA-1254. +target gene 34531985 hsa-mir-145 Stomach Neoplasms Muscone suppresses gastric cancer via regulation of miRNA-145. +lncRNA target 34531932 hsa-mir-10b Breast Neoplasms BACKGROUND: In our earlier work, we identified microRNA-10b (miR10b) as a master regulator of the viability of metastatic tumor cells. In addition, we evaluated the uptake of (64)Cu-MN-anti-miR10b by metastatic lesions using both in vivo and ex vivo positron emission tomography-magnetic resonance imaging (PET-MRI). +lncRNA target 34531932 hsa-mir-10b Neoplasm Metastasis BACKGROUND: In our earlier work, we identified microRNA-10b (miR10b) as a master regulator of the viability of metastatic tumor cells. In addition, we evaluated the uptake of (64)Cu-MN-anti-miR10b by metastatic lesions using both in vivo and ex vivo positron emission tomography-magnetic resonance imaging (PET-MRI). +target gene 34531912 hsa-mir-200b Stomach Neoplasms MiR-200b Suppresses Gastric Cancer Cell Migration and Invasion by Inhibiting NRG1 through ERBB2/ERBB3 Signaling. +target gene 34531664 hsa-mir-34c Lung Neoplasms CircPTCH1 Promotes Migration in Lung Cancer by Regulating MYCN Expression Through miR-34c-5p. +transcription factor target 34531509 hsa-mir-338 Intervertebral Disc Degeneration 3p as a mediator of IDD and thus may be a promising target for rescuing IDD. +genetics_GWAS 34531437 hsa-mir-22 Thyroid Nodule 3p/CBL axis was established to explain the effect of SNP of circ-ITCH in thyroid tumor malignancy. +genetics_knock down_promote 34531378 hsa-mir-139 Liver Cirrhosis 5p overexpression alleviated murine liver fibrosis. +circRNA target 34530825 hsa-mir-107 Esophageal Squamous Cell Carcinoma SLC1A5 was a target of miR-107, and it worked as an oncogene in EC cells. +target gene 34530822 hsa-mir-550a Lung Neoplasms MicroRNA-550a-3-5p controls the brain metastasis of lung cancer by directly targeting YAP1. +lncRNA target 34530821 hsa-mir-613 Thyroid Cancer, Papillary CONCLUSION: Our findings demonstrated that miR-613 can suppress the progression of PTC cells by targeting TAGLN2, indicating that miR-613 plays the role of a tumor suppressor in PTC. +other 34530741 hsa-mir-146b Coronary Artery Disease CONCLUSION: hsa-miR5p, has-miR-146b-5p, CAV1 and HSF2 could play an important role in CAD. +other 34530741 hsa-mir-361 Coronary Artery Disease CONCLUSION: hsa-miR5p, has-miR-146b-5p, CAV1 and HSF2 could play an important role in CAD. +other 34530722 hsa-mir-92a Thrombosis BACKGROUND: MiR-92a-3p and oxidative stress are associated with catheter-related thrombosis (CRT). +circulation_biomarker_diagnosis_up 34530722 hsa-mir-92a Colorectal Neoplasms In the CRT RE group, after administering the resistance exercise intervention, ROS production and MDA activity in serum significantly decreased, the expression level of HO-1 increased and the expression level of miR-92a-3p in the venous tissues significantly decreased and was negatively correlated with that of HO-1. +other 34530722 hsa-mir-92a Upper Extremity Deep Vein Thrombosis BACKGROUND: MiR-92a-3p and oxidative stress are associated with catheter-related thrombosis (CRT). +other 34530424 hsa-mir-7a Bone Diseases The results may shed light on application of miR-7a-5p and miR-592 for maintaining osteo-differentiation potential in stem cells for bone regeneration and bone-related disease treatment. +other 34530424 hsa-mir-592 Bone Diseases The results may shed light on application of miR-7a-5p and miR-592 for maintaining osteo-differentiation potential in stem cells for bone regeneration and bone-related disease treatment. +genetics_overexpression_promote 34530115 hsa-mir-363 Glioblastoma 3p depletion or overexpression of NOB1. +lncRNA target 34529965 hsa-let-7f Vascular Diseases Herein, we investigated the functions of microRNA let-7f (also termed let-7f-5p) in vascular endothelial cell dysfunction. In conclusion, let-7f alleviates vascular endothelial cell dysfunction by downregulating HMGA2 expression under OGD/R. +other 34528912 hsa-mir-661 Carcinoma, Non-Small-Cell Lung Hsa_circ_0001947 acts as a sponge of miR-661 to repress NSCLC development by elevating the expression of DOK7. +lncRNA target 34528899 hsa-mir-497 Myocardial Infarction This study provides novel potential therapeutic thought for the prevention and treatment of MI through targeting miR-497/Smad7. +lncRNA target 34528899 hsa-mir-497 Heart Diseases Some microRNAs (miRNAs) including miR-497 and related target genes have been proved to be closely linked with heart diseases. +lncRNA target 34528899 hsa-mir-497 Heart Injuries CONCLUSIONS: We found that EVs isolated from MSCs might improve the cardiac injury caused by MI through targeting miR497/Smad7. +other 34528842 hsa-mir-122 Chemical and Drug Induced Liver Injury Introduction: MicroRNA-122 (miR-122) is a novel biomarker of liver injury and has been proposed as an early predictor of acetaminophen-associated hepatotoxicity. +other 34528556 hsa-mir-145 Endometrial Neoplasms miR-145 was significantly upregulated in endometriosis and endometrioid ovarian cancer but significantly downregulated in endometrial cancer. ROC curve analysis revealed that for endometriosis, miR-99b, and miR-125a were giving highest area under curve (AUC) (0.950 and 0.733, respectively), for endometrioid carcinoma of ovary miR-143 was giving highest AUC (0.933) and for endometrioid endometrial cancer miR-16 (AUC = 0.815), miR-99b (AUC = 0.920), and miR-145 (AUC = 0.985) were found to be best predictors. +other 34528556 hsa-mir-145 Endometriosis miR-145 was significantly upregulated in endometriosis and endometrioid ovarian cancer but significantly downregulated in endometrial cancer. ROC curve analysis revealed that for endometriosis, miR-99b, and miR-125a were giving highest area under curve (AUC) (0.950 and 0.733, respectively), for endometrioid carcinoma of ovary miR-143 was giving highest AUC (0.933) and for endometrioid endometrial cancer miR-16 (AUC = 0.815), miR-99b (AUC = 0.920), and miR-145 (AUC = 0.985) were found to be best predictors. +other 34528556 hsa-mir-145 Carcinoma, Endometrioid miR-145 was significantly upregulated in endometriosis and endometrioid ovarian cancer but significantly downregulated in endometrial cancer. ROC curve analysis revealed that for endometriosis, miR-99b, and miR-125a were giving highest area under curve (AUC) (0.950 and 0.733, respectively), for endometrioid carcinoma of ovary miR-143 was giving highest AUC (0.933) and for endometrioid endometrial cancer miR-16 (AUC = 0.815), miR-99b (AUC = 0.920), and miR-145 (AUC = 0.985) were found to be best predictors. +lncRNA target 34528480 hsa-mir-149 Noonan syndrome-like disorder with loose anagen hair Our data suggest that miR-149 is involved in the etiology of nsCL/P via its role in hNCC migration. +lncRNA target 34528480 hsa-mir-149 Lesch-Nyhan Syndrome Our data suggest that miR-149 is involved in the etiology of nsCL/P via its role in hNCC migration. +circRNA target 34528447 hsa-mir-224 Inflammatory Bowel Diseases Conclusion: Hsa_circ_0001021 is related to UC severity and regulates epithelial barrier function via sponging miR5p. +other 34528314 hsa-mir-339 Breast Neoplasms 5p in BC tumor compared to corresponding adjacent tissues. +other 34528314 hsa-mir-335 Breast Neoplasms 5p in BC tumor compared to corresponding adjacent tissues. +circulation_biomarker_diagnosis_up 34528223 hsa-mir-129 Non-alcoholic Fatty Liver Disease Serum miR +genetics_knock down_suppress 34528144 hsa-mir-643 Squamous Cell Carcinoma of Head and Neck MiR-643 overexpression had an inhibition effect on OSCC progression, and its inhibitor could reverse the negative regulation of circLPAR3 knockdown on OSCC progression. +therapeutic target 34527562 hsa-mir-516b Thyroid Cancer, Papillary This study verified the novel function of the circRAD18-miR-516b-PDK1 axis in papillary thyroid cancer metabolic reprogramming progression, which has potential to be a novel therapeutic target. +transcription factor target 34527345 hsa-mir-204 Aortic Valve Insufficiency CONCLUSIONS: Regulated by miRNA3p, CXCR4 could inhibit the progression of AR after HTx. +circulation_biomarker_diagnosis_ns 34527338 hsa-mir-122 Essential Hypertension The purpose of our research was to investigate the correlation between serum miR-122 and myocardial damage and ventricular functions in EH patients. CONCLUSIONS: The serum miR-122 concentration in EH patients was higher than that in healthy individuals, and miR-122 concentration was positively correlated with myocardial damage markers. +target gene 34527128 hsa-mir-367 Carcinoma, Non-Small-Cell Lung Circular RNA La-related protein 4 inhibits cell proliferation, migration, and invasion and sponges microRNA-367 in non-small cell lung cancer. +lncRNA target 34527075 hsa-mir-190a Glioma miR-190a-3p was expected to be a new target for molecular therapy of glioma. +other 34526802 hsa-mir-940 Cardiomyopathies CONCLUSION: The downregulation of miR-940 was reported and it might be an underlying diagnostic marker in sepsis patients. +other 34526802 hsa-mir-940 Sepsis CONCLUSION: The downregulation of miR-940 was reported and it might be an underlying diagnostic marker in sepsis patients. +transcription factor target 34526481 hsa-mir-206 Myocardial Reperfusion Injury Coherently, HDAC4 silencing could up-regulate the expression of miR-206 to reduce cardiomyocyte apoptosis and inhibit oxidative stress, and exerting a protective effect on MIRI via the MEKK1/JNK pathway. +lncRNA target 34526098 hsa-mir-1236 Cholangiocarcinoma CONCLUSIONS: CircHMGCS1-016 is a forceful contributor in ICC development and immune tolerance via miR +transcription factor target 34525985 hsa-mir-22 Asthma This gene is targeted by eight asthma related miRNAs (hsa-miR-206, hsa-miR-19a, hsa-miR-9,hsa-miR-22, hsa-miR-33b, hsa-miR-122, hsa-miR-1, and hsa-miR-23b). +transcription factor target 34525985 hsa-mir-122 Asthma This gene is targeted by eight asthma related miRNAs (hsa-miR-206, hsa-miR-19a, hsa-miR-9,hsa-miR-22, hsa-miR-33b, hsa-miR-122, hsa-miR-1, and hsa-miR-23b). +transcription factor target 34525985 hsa-mir-1 Asthma This gene is targeted by eight asthma related miRNAs (hsa-miR-206, hsa-miR-19a, hsa-miR-9,hsa-miR-22, hsa-miR-33b, hsa-miR-122, hsa-miR-1, and hsa-miR-23b). +transcription factor target 34525985 hsa-mir-9 Asthma This gene is targeted by eight asthma related miRNAs (hsa-miR-206, hsa-miR-19a, hsa-miR-9,hsa-miR-22, hsa-miR-33b, hsa-miR-122, hsa-miR-1, and hsa-miR-23b). +transcription factor target 34525985 hsa-mir-23b Asthma This gene is targeted by eight asthma related miRNAs (hsa-miR-206, hsa-miR-19a, hsa-miR-9,hsa-miR-22, hsa-miR-33b, hsa-miR-122, hsa-miR-1, and hsa-miR-23b). +transcription factor target 34525985 hsa-mir-19a Asthma This gene is targeted by eight asthma related miRNAs (hsa-miR-206, hsa-miR-19a, hsa-miR-9,hsa-miR-22, hsa-miR-33b, hsa-miR-122, hsa-miR-1, and hsa-miR-23b). +transcription factor target 34525985 hsa-mir-206 Asthma This gene is targeted by eight asthma related miRNAs (hsa-miR-206, hsa-miR-19a, hsa-miR-9,hsa-miR-22, hsa-miR-33b, hsa-miR-122, hsa-miR-1, and hsa-miR-23b). +lncRNA target 34525952 hsa-mir-182 Prostatic Neoplasms These findings show that miR-182 is highly expressed in AA patients and miR-182 may be a target for effective therapy in AA patients. +other 34525946 hsa-mir-200c Angelman Syndrome However, the functional role of miR-200c-3p in AS remains largely unknown. Here, we demonstrated the critical role of miR-200c-3p in regulating EndMT in AS. +transcription factor target 34525477 hsa-mir-590 Periodontitis Collectively, EVs carried miR3p into macrophages to subsequently inhibit TLR4 transcription, thereby reducing macrophage pyroptosis and alleviating periodontal inflammatory injury. +transcription factor target 34525477 hsa-mir-590 Periodontal Diseases Collectively, EVs carried miR3p into macrophages to subsequently inhibit TLR4 transcription, thereby reducing macrophage pyroptosis and alleviating periodontal inflammatory injury. +other 34525476 hsa-mir-1298 Carcinoma, Non-Small-Cell Lung lncRNA OSER1-AS1 had a higher diagnostic value in patients with NSCLC than miR5p and CHSY3. +lncRNA target 34524611 hsa-mir-200c Stomach Neoplasms In addition, down-regulation of miR-200c-3p suppressed cell viability, proliferation, migration, and invasion in GCC cells. +circRNA target 34524572 hsa-mir-21 Emphysema These results demonstrated that, in alveolar epithelial cells, CS decreases circRNA_0026344 levels, which sponge miR-21 to inhibit the miR-21 target, PTEN, which, in turn, activates ERK and thereby promotes autophagy and apoptosis, leading to emphysema. Thus, for emphysema, circRNA_0026344 regulates the PTEN/ERK axis by sponging miR-21, which is associated with the CS-induced autophagy and apoptosis of alveolar epithelial cells. +circulation_biomarker_diagnosis_up 34524260 hsa-mir-125b Myocardial Infarction T-qPCRs were performed to measure the expression levels of MFACR and miR-125b in plasma samples from both MI patients (n = 61) and healthy controls (n = 61). We found that MFACR was upregulated in MI and inversely correlated with miR-125b. +genetics_overexpression_promote 34523750 hsa-mir-21 Glioma 3p overexpression, cell viability and apoptosis of glioma cell lines treated with FXT (50 mumol/L) were tested again. +lncRNA target 34523739 hsa-mir-487a Carcinoma, Non-Small-Cell Lung Retraction: 'Downregulation of miR-487a-3p suppresses the progression of non-small cell lung cancer via targeting Smad7' by Fan Y, Hao J, Cen X, Song K, Yang C, Xiao S, Cheng S, Drug Development Research. +other 34523694 hsa-mir-31 Pre-Eclampsia Mechanistically, it was concluded that hsa_circ_0026552 acts as a miR3313p sponge to upregulate TGFbetaR1 expression in trophoblasts and is involved significantly in PE development and progression in pregnant women. +lncRNA target 34523356 hsa-mir-20b Colorectal Neoplasms Results:HCG18 and PD-L1 were upregulated while miR-20b-5p was downregulated in CRC tissue. Functional analysis revealed that lncRNA HCG18 promoted proliferation, migration and resistance to cetuximab of CRC cells via the miR-20b-5p/PD-L1 axis. +other 34523052 hsa-mir-132 Neonatal Sepsis 3p. +genetics_overexpression_promote 34522457 hsa-mir-374b Pancreatic Carcinoma In vitro assays indicated that overexpression of miR-374b-5p suppressed the proliferation, migration, and invasion of PC cells. +target gene 34522453 hsa-mir-506 Pancreatic Neoplasms Downregulation of NEAT1 sensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine through modulation of the miR-506-3p/ZEB2/EMT axis. +exosome 34522205 hsa-mir-21 Fibrosis, Renal Conclusion: Our findings reveal that exosomal miR-21 from tubular epithelial cells may accelerate the development of renal fibrosis by activating fibroblasts via the miR-21/PTEN/Akt pathway in obstructed kidneys. +exosome 34522205 hsa-mir-21 Kidney Diseases Conclusion: Our findings reveal that exosomal miR-21 from tubular epithelial cells may accelerate the development of renal fibrosis by activating fibroblasts via the miR-21/PTEN/Akt pathway in obstructed kidneys. +genetics_overexpression_promote 34522182 hsa-mir-139 Carcinoma, Hepatocellular 5p, CCT5 was overexpressed in HCC tumor tissues and peripheral blood mononuclear cells (all P < 0.05). +circRNA target 34522177 hsa-mir-616 Endometriosis These results demonstrated that the downregulation of circ_0000673 could promote the progression of endometriosis by inactivating PTEN via the deregulation of miR3p. +other 34522168 hsa-mir-125a Pulmonary Fibrosis The miRNAs including miR-199b-5p, miR5p, miR-199a-5p, miR-125A-5p, and miR-107 that we predicted would regulate the VEGFA, CDH5, and WNT3A genes, which were also associated with IPF or other fibrosis-related diseases. +genetics_knock down_promote 34522027 hsa-mir-130a Uveal melanoma Taken together, overexpressed miR-130a inhibited USP6 expression to repress UM cell migration and invasion abilities through inactivating the Wnt/beta-catenin signaling pathway, which could be a potential candidate for treatment of UM. +lncRNA target 34521449 hsa-mir-497 Liver Cirrhosis Furthermore, miR-497 inhibitor delivered by highly-hepatotropic (rAAV8) inhibited TGF-beta/smads signaling pathway by targeting at Smad7 to ameliorate CCL4-induced liver fibrosis. CONCLUSIONS: The present study demonstrates that miR-497 promotes liver fibrogenesis by targeting Smad7 to promote TGF-beta/Smad signaling pathway transduction both in vivo and in vitro, which provides a promising therapeutic strategy using anti-miR-497 against liver fibrosis. +exosome 34521413 hsa-mir-449a Carcinoma, Non-Small-Cell Lung Engineered exosomes loaded with miR-449a selectively inhibit the growth of homologous non-small cell lung cancer. +lncRNA target 34521353 hsa-mir-24 Ischemic Stroke CONCLUSION: This study presents that depleting SOX2 improves IS via PVT1/miR +other 34520874 hsa-mir-622 Sepsis MiR-519c-5p, miR-3622b-3p were novel biomarkers for diagnosing septic patients. +other 34520874 hsa-mir-519c Sepsis MiR-519c-5p, miR-3622b-3p were novel biomarkers for diagnosing septic patients. +genetics_overexpression_promote 34520626 hsa-mir-19b Colorectal Neoplasms It was found that miR-19b was overexpressed in CRC tissues, which indicated a poor prognosis. +lncRNA target 34520391 hsa-mir-378b Glioma The inhibition of miR-378b or the enhancement of SLC2A1 reversed ZNF609 depletion-regulated glioma cell proliferation in vitro. +genetics_knock down_suppress 34520298 hsa-mir-342 Carcinoma, Non-Small-Cell Lung The overexpression of microRNA +other 34520170 hsa-mir-34a Obesity We investigated if BBP altered miR-34a-5p, a key miRNA involved in obesity, and regulated its downstream pathway. +lncRNA target 34520102 hsa-mir-378a Ovarian Neoplasms GALNT3 was a target gene of miR-378a-3p in OC. Overall, PSMA3-AS1 promotes OC cell proliferation, migration, invasion, and xenograft tumor growth by activating the PI3K/Akt pathway via the miR-378a-3p/GALNT3 axis. +genetics_knock down_promote 34519997 hsa-mir-937 Carcinoma, Hepatocellular Overexpression of miR-937 promoted HCC cell ability of proliferation, migration, and invasiveness, while knockdown of miR-937 inhibited these cellular behaviors. +genetics_overexpression_promote 34519914 hsa-mir-29a Sepsis Overexpression of miR-29a or inhibition of E2F2 abrogated the suppressive effect of TTN-AS1 overexpression on myocardial injury. CONCLUSION: This study indicates TTN-AS1 attenuates sepsis-induced myocardial injury by regulating the miR-29a/E2F2 axis and sheds light on lncRNA-based treatment of sepsis-induced cardiomyopathy. +genetics_overexpression_promote 34519914 hsa-mir-29a Myocardial Infarction Overexpression of miR-29a or inhibition of E2F2 abrogated the suppressive effect of TTN-AS1 overexpression on myocardial injury. CONCLUSION: This study indicates TTN-AS1 attenuates sepsis-induced myocardial injury by regulating the miR-29a/E2F2 axis and sheds light on lncRNA-based treatment of sepsis-induced cardiomyopathy. +genetics_knock down_promote 34519634 hsa-mir-153 Carcinoma, Hepatocellular In addition, knockdown of TWF1 inhibited DDP resistance of HCC cells, which was reversed by miR +other 34519627 hsa-mir-637 Atherosclerosis In conclusion, circUSP36 regulated WNT4 to aggravate endothelial cell injury caused by ox-LDL by competitively binding to miR-637; this finding indicates circUSP36 to be a promising biomarker for the diagnosis and therapy of atherosclerosis. +genetics_overexpression_promote 34519373 hsa-mir-151a Glioma Further inhibition of miR-151a or overexpression of CENPB restored radioresistance of glioma cells. +lncRNA target 34519263 hsa-mir-486 Dehydration 5p and upregulating PIM1, which may be related to the inhibition of TGF-beta/Smad pathway. +transcription factor target 34519263 hsa-mir-486 Leukemia, Myeloid Proviral integration site for Moloney murine leukemia virus 1 (PIM1) was verified to be targeted by miR5p. +other 34519258 hsa-mir-106b Carcinoma, Non-Small-Cell Lung In mechanism, circ_0000677 acted as a sponge of microRNA-106b and further regulated CCDND1 gene expression in NSCLC cells by dual luciferase activity assay and their expression examination. Taken together, these findings suggest a role for circ_0000677/miR-106b/CCND1 regulation axis in promoting NSCLC growth and progression. +genetics_knock down_promote 34519257 hsa-mir-646 Acute Coronary Syndrome The knockdown of miR-3646 could alleviate ACS by reversing inflammatory response. +exosome 34519129 hsa-mir-24 Pancreatic Carcinoma To conclude, exosomal-mediated SNHG11 could regulate PC progression via miR3p/VEGFA axis. +genetics_GWAS 34518949 hsa-mir-522 Triple Negative Breast Neoplasms Besides, functional studies in two triple-negative breast cancer cell lines showed that overexpression of miR-522 significantly promoted cell proliferation, migration, and invasion in vitro. +genetics_knock down_suppress 34518490 hsa-mir-182 Neurogenic Inflammation However, the injection of miR5p antagomir significantly reversed the level of the NP behaviors and neuroinflammation caused by PCAT19 knockdown. +genetics_knock down_suppress 34518490 hsa-mir-182 Neuralgia However, the injection of miR5p antagomir significantly reversed the level of the NP behaviors and neuroinflammation caused by PCAT19 knockdown. +genetics_overexpression_promote 34518486 hsa-mir-433 Glioma 3p and AJUBA, it was found that overexpressing AJUBA could attenuate the inhibitory effect of overexpressing miR +genetics_knock down_promote 34518485 hsa-mir-23a Wilms Tumor CONCLUSIONS: The cell viability, migration, and invasiveness of WT cells were repressed by MEG8 knockdown via targeting the miR-23a-3p/CRK axis. +lncRNA target 34518442 hsa-mir-28 Carcinoma, Renal Cell 3p-FAM193B loop could serve as a potential biomarker and therapeutic target for ccRCC. +lncRNA target 34518440 hsa-mir-942 Osteosarcoma In conclusion, HCG11 is downregulated in OS, and restrains OS growth both in vitro and in vivo by raising p27 Kip1 expression via binding to miR5p and IGF2BP2. +other 34518132 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck OBJECTIVE: Evaluation of diagnostic accuracy of microRNA-21 (miR-21) in saliva and tumor tissue for presurgical assessment of lymph node metastasis in patients with oral squamous cell carcinoma (OSCC). CONCLUSIONS: miR-21 expression in saliva and tumor tissue of patients with OSCC showed high diagnostic accuracy for assessment of cervical lymph node metastasis. +other 34517910 hsa-mir-146a Pre-Eclampsia OBJECTIVE: This study aims to identify the effect of miR-146a-5p on trophoblast cell invasion as well as the mechanism in preeclampsia (PE). RESULTS: Compared with normal placental tissues, the placentae from PE patients showed higher miR-146a-5p expression and lower Wnt2 expression. +transcription factor target 34517822 hsa-mir-3 Lipid Metabolism Disorders CONCLUSIONS: This study demonstrated the crucial roles played by the miR5p/ABCA1/CS axis in regulating cholesterol efflux, inflammation, apoptosis, and aging in VECs, and also suggested the axis as a target for managing lipid metabolism disorders. +transcription factor target 34517822 hsa-mir-3 Inflammation CONCLUSIONS: This study demonstrated the crucial roles played by the miR5p/ABCA1/CS axis in regulating cholesterol efflux, inflammation, apoptosis, and aging in VECs, and also suggested the axis as a target for managing lipid metabolism disorders. +genetics_knock down_promote 34517790 hsa-mir-216a Neuralgia Functional rescue experiments manifested that the suppressive effect of circSMEK1 knockdown on NP was reversed by declined miR-216a-5p simultaneously. +lncRNA target 34517787 hsa-mir-338 Spinal Cord Injuries Together, TUG1 silencing could alleviate the death in neurons and ASCI models via modulating the miR-338/BIK axis. +other 34517612 hsa-mir-141 Prostatic Neoplasms Herein, for the first time, an electrochemical sensing platform based on atom transfer radical polymerization (ATRP) signal amplification strategy for ultrasensitive determination of the breast and prostate cancer marker miRNA-141 has been developed. +genetics_overexpression_promote 34516983 hsa-mir-503 Hyperglycemia Taken together, these findings demonstrate that overexpression of hsa_circ_0022742 suppressed HG-induced endothelial dysfunction by targeting the miR +lncRNA target 34516362 hsa-mir-194 Esophageal Squamous Cell Carcinoma Collectively, lncRNA KCNMB2-AS1 promotes ESCA development through targeting the miR3p/ PYGL axis, which might provide theoretical basis to explore novel biomarkers for ESCA treatment. +lncRNA target 34516355 hsa-mir-21 Polycystic Ovary Syndrome The aim of the study was to assess microRNA-21 regulates granulosa cell apoptosis and proliferation in polycystic ovary syndrome through target toll-like receptor 8. +genetics_knock down_promote 34516354 hsa-mir-580 Leukemia, Myeloid, Acute In conclusion, SATB1-AS1 knockdown promotes the sensitivity of AML cells by upregulating miR-580 and downregulating OAS2 through the GSK3beta/beta-catenin pathway, providing new insights into the function of SATB1-AS1 as a miRNA sponge in AML. +lncRNA target 34516353 hsa-mir-520h Carcinoma, Hepatocellular Our results showed that IGF2-AS expression was significantly down-regulated in HCC cells and tissues; lower IGF2-AS expression was significantly associated with poor prognosis of HCC patients; IGF2-AS over-expression inhibited the viability, colony formation, invasion, and migration, while promoted apoptosis in vitro, and inhibited HCC xenograft growth in vivo; IGF2-AS sponged microRNA-520h (miR-520h) to up-regulate IGF2-AS expression, and miR-520h over-expression or cyclin-dependent kinase inhibitor 1A (CDKN1A) silencing reversed IGF2-AS reduced aggressive behaviors of HCC cells. In conclusion, IGF2-AS is a tumor-suppressor in HCC, and lower IGF2-AS expression is associated with poor prognosis of HCC patients; IGF2-AS inhibits HCC oncogenesis and development by IGF2-AS/miR-520h/CDKN1A pathway. +lncRNA target 34516344 hsa-mir-451a Nasopharyngeal Carcinoma miR-451a suppresses CSE1L expression, thereby reducing proliferation, invasion, and migration and increasing apoptosis of NPC cells. +other 34516341 hsa-mir-129 Carcinoma, Renal Cell Therefore, hsa_circ_0002024 was identified as a prognostic ceRNA that might sponge hsa_miR_129-5p to regulate ASF1B and affect RCC prognosis. +lncRNA target 34516335 hsa-mir-613 Esophageal Squamous Cell Carcinoma Moreover, RMRP promoted the proliferation, migration, and invasion of ESCC cells via regulating miR-613/NRP2.RMRP was involved in the progression of ESCC through regulating the miR-613/NRP2 axis, which provides a potential target for the treatment of ESCC. +genetics_overexpression_promote 34516334 hsa-mir-495 Carcinoma, Hepatocellular The in vivo experiment demonstrated miR-495 overexpression had great therapeutic effects on HCC in xenograft. +genetics_overexpression_suppress 34516333 hsa-mir-361 Carcinoma, Renal Cell 3p inhibitor or PGF overexpression could relieve the inhibitory effect of silencing ARAP1-AS1 on ccRCC cells. +genetics_overexpression_promote 34516330 hsa-mir-215 Stomach Neoplasms 3p overexpression counteracted the biological effects of PCED1B-AS1. +lncRNA target 34516316 hsa-mir-221 Pulmonary Disease, Chronic Obstructive 3p alleviated cell apoptosis and inflammatory response via targeting CDKN1B in an in vitro model of COPD. +lncRNA target 34516314 hsa-mir-198 Colorectal Neoplasms Our findings identify circ_0089153 as a novel regulator of CRC development through the regulation of the miR-198/SENP1 axis and establish a strong rationale for developing circ_0089153 as a promising therapeutic against CRC. +genetics_GWAS 34515927 hsa-mir-143 Schizophrenia We aimed to investigate the link between rs4705342T/C and rs4705343T/C polymorphisms in the promoter region of miR-143 and the risk of schizophrenia (SCZ) in a sample of an Iranian population. The result of the bioinformatics analysis showed that miR-143, as a critical miRNA, targets ERK5, ERBB3, HK2, and PKCepsilon, the four major genes involved in SCZ development. +genetics_overexpression_promote 34515875 hsa-mir-375 Rectal Neoplasms MiR-375 overexpression suppressed the malignant behaviors of rectal cancer cells partly through down-regulating ROCK1. +genetics_knock down_suppress 34515612 hsa-mir-337 Cardiomegaly An adenovirus vector system was employed to knockdown miR +other 34515323 hsa-mir-532 Diabetes Mellitus The expression of microRNA (miR)5325P is downregulated in diabetes, but its specific role in diabetes has not yet been elucidated. The present study aimed to investigate the specific mechanism underlying the effects of miR5325p on diabetes. +genetics_overexpression_promote 34515321 hsa-mir-218 Urinary Bladder Neoplasms Furthermore, miR218 overexpression blocked the promoting effects of Rab6c on the malignant behavior of bladder cancer cells. +genetics_knock down_promote 34515320 hsa-mir-761 Colorectal Neoplasms Collectively, the present results suggested that knockdown of PVT1 may inhibit the progression of CRC by regulating the miR761/MAPK1 axis, which may provide a promising biomarker for the treatment of CRC. +circulation_biomarker_diagnosis_ns 34515297 hsa-mir-19a Myocardial Infarction We found that DANCR expression and miR-19a-3p level are negatively correlated as DANCR expression is increased, while miR-19a-3p level is decreased in AMI patients' serum and OGD/R-exposed HL-1 cells. +genetics_overexpression_promote 34515239 hsa-mir-224 Carcinoma, Renal Cell Overexpression of OCLN could reduce the proliferation, migration, and invasion of ccRCC cells, while overexpressed miR +other 34515193 hsa-mir-126 Leukemia, Myelogenous, Chronic, BCR-ABL Positive CONCLUSION The study concludes that expression of miR-126 and miR-122 increases after imatinib treatment in CML patients and that miR-126 defines the good responders of imatinib therapy. +other 34515180 hsa-mir-29a Nervous System Diseases Additionally, the repressive action of NGR1 in neurological impairment and neuroinflammation was eliminated by downregulating miR-29a in rats. +other 34515180 hsa-mir-29a Parkinson Disease Additionally, the repressive action of NGR1 in neurological impairment and neuroinflammation was eliminated by downregulating miR-29a in rats. +circulation_biomarker_diagnosis_down 34515176 hsa-mir-150 Parkinson Disease 5p was the target gene of RMST and less expressed in the clinical serum samples and PD cell models. +circulation_biomarker_diagnosis_up 34514705 hsa-mir-193b Thyroid Neoplasms TC cells were transfected with DLX6-AS1/miR-193b-3p-related oligonucleotides or plasmids to test cell growth and autophagy. +transcription factor target 34514658 hsa-mir-935 Sveinsson Chorioretinal Atrophy Of these 4 miRs, miR-3935 stood out, as its predicted target PTGER3, the prostaglandin EP(3) receptor, was downregulated in treated AA patients compared with untreated. +transcription factor target 34514658 hsa-mir-935 Hypersensitivity CONCLUSIONS: While profiling the sputum of allergic patients for novel miR expression patterns, we uncovered an association between miR-3935 and its predicted target gene, the prostaglandin E(3) receptor, which might mediate AIT effects through suppression of the PGE(2) -PTGER3 axis. +target gene 34514167 hsa-mir-496 Stomach Neoplasms miR-496 inhibits proliferation via LYN and AKT pathway in gastric cancer. +genetics_knock down_promote 34514098 hsa-mir-26a Stomach Neoplasms Loc100506691 negatively regulated CHAC1 expression by modulating miR-26a-5p/miR-330-5p expression, and CHAC1 knockdown markedly attenuated Loc100506691 knockdown-induced gastric cancer cell growth and motility suppression. +genetics_knock down_promote 34514098 hsa-mir-30 Stomach Neoplasms Loc100506691 negatively regulated CHAC1 expression by modulating miR-26a-5p/miR-330-5p expression, and CHAC1 knockdown markedly attenuated Loc100506691 knockdown-induced gastric cancer cell growth and motility suppression. +transcription factor target 34514096 hsa-mir-1207 Squamous Cell Carcinoma of Head and Neck 5p inhibited LSCC malignant progression by downregulating SKA3 and preventing EMT. +lncRNA target 34514002 hsa-mir-423 Carcinoma, Renal Cell Next, our experiments found that circFOXP1 upregulated U2AF2 expression via sponging miR +transcription factor target 34513987 hsa-mir-137 Hypoxia The present study found for the first time that miR-137 was downregulated in pulmonary arteries of hypoxic PH rats and in hypoxia-treated PASMCs. Our study demonstrated that hypoxia-induced downregulation of miR-137 expression promoted the proliferation of PASMCs by targeting calpain-2, thereby potentially resulting in pulmonary vascular remodeling in hypoxic PH. +transcription factor target 34513987 hsa-mir-137 Hypertension, Pulmonary Our study demonstrated that hypoxia-induced downregulation of miR-137 expression promoted the proliferation of PASMCs by targeting calpain-2, thereby potentially resulting in pulmonary vascular remodeling in hypoxic PH. +transcription factor target 34513931 hsa-mir-223 Diabetic Keratopathy 5p suppression ameliorated inflammation and enhanced cell proliferation signaling in DK. +other 34513927 hsa-mir-126 Hind Limb Ischemia The Effect of MicroRNA-126 Mimic Administration on Vascular Perfusion Recovery in an Animal Model of Hind Limb Ischemia. A statistically significant negative correlation was noted between microRNA-126 and VEGF tissue expression levels in the ischemic limbs of the entire study population. +circulation_biomarker_diagnosis_ns 34513856 hsa-mir-3 Niemann-Pick Diseases Dietary cholesterol levels did not affect the microbiome and neither did alterations of plasma lipid levels through treatments of miR-33 antisense oligonucleotide (anti-miR-33), Niemann-Pick C1-Like 1 (NPC1L1) antisense oligonucleotide (ASO), and inducible degrader of LDLR (IDOL) ASO. +target gene 34513821 hsa-mir-124 Uterine Cervical Neoplasms LncRNA OIP5-AS1 Regulates the Warburg Effect Through miR-124-5p/IDH2/HIF-1α Pathway in Cervical Cancer. +exosome 34513819 hsa-mir-15b Tendon Injuries Taken together, the results show that M2 macrophage-derived circRNA-Ep400-containing exosomes promote peritendinous fibrosis after TI via the miR-15b-5p/FGF-1/7/9 pathway, which suggests novel therapeutics for tendon injury treatment. +transcription factor target 34513812 hsa-mir-100 Heart Failure In conclusion, these results indicate that HucMSC-EVs inhibit DOX-induced heart failure through the miR5p/NOX4 pathway. +transcription factor target 34513803 hsa-mir-101 Intervertebral Disc Degeneration 3p inhibitor, the expressions of ECM-related proteins, cell viability, and apoptosis were detected. +lncRNA target 34513693 hsa-mir-214 Carcinoma, Hepatocellular Rescue assays demonstrated that functions of LINC00882 deficiency in HCC cells were reversed through suppressing miR +other 34513660 hsa-mir-24 Adenocarcinoma of Lung In the present study, qRT-PCR was used to measure the levels of GAS6-AS1, GIMAP6 and miR3p expression in LUAD samples and cell lines. +genetics_overexpression_promote 34513340 hsa-mir-140 Squamous Cell Carcinoma of Head and Neck 3p in LSCC was verified in the experiment, and it was proved that overexpression of miR +other 34513304 hsa-mir-382 Infertility 3p in pubertal Scs could be one of the underlying causes of idiopathic male infertility and should be considered for diagnosis and treatment of infertility. +other 34513304 hsa-mir-382 Infertility, Male Hence, sustained high levels of miR3p in pubertal Scs could be one of the underlying causes of idiopathic male infertility and should be considered for diagnosis and treatment of infertility. +lncRNA target 34513303 hsa-mir-218 Diabetes Mellitus, Type 1 Importantly, miR-218 was found to be upregulated in DM1 muscle biopsies, pinpointing this microRNA (miRNA) as a relevant therapeutic target. +lncRNA target 34513301 hsa-mir-92a Ischemic Stroke Mechanistic analysis revealed that lncRNA XIST modulated angiogenesis and alleviated cerebral vascular injury following CIS through mediating the miR-92a/Itgalpha5 or KLF4 axis, respectively. +other 34513297 hsa-mir-432 Liver Neoplasms circ-PRKAR1B/miR-432-5p/E2F3 signaling involved in liver cancer progression +lncRNA target 34513288 hsa-mir-586 Breast Neoplasms Moreover, we demonstrated that LINC01189 functioned as a tumor suppressor and inhibited breast cancer progression through inhibiting an epithelial-mesenchymal transition (EMT)-like phenotype by sponging miR-586. +circulation_biomarker_diagnosis_ns 34512893 hsa-mir-129 Diabetic Angiopathies CONCLUSION: Elevated serum miR +circulation_biomarker_diagnosis_ns 34512893 hsa-mir-129 Diabetes Mellitus CONCLUSION: Elevated serum miR +other 34512861 hsa-mir-223 Kidney Calculi Our results suggest that the lncRNA XIST participates in the formation and progression of renal calculus by interacting with miR3p and the NLRP3/Caspase-1/IL-1beta pathway to mediate the inflammatory response and ROS production. +target gene 34512774 hsa-mir-375 Uterine Cervical Neoplasms miR-375 inhibits the malignant development of human cervical cancer cells by regulating the expression of YAP1. +circRNA target 34512755 hsa-mir-96 Pancreatic Carcinoma 5p/KRAS/MAPK signaling pathway and might be a hopeful therapeutic target for PC. +other 34512753 hsa-mir-485 Stomach Neoplasms LncRNA SNHG7 Regulates Gastric Cancer Progression by miR-485-5p. +target gene 34512751 hsa-mir-485 Liver Neoplasms LncRNA NKILA Promotes Epithelial-Mesenchymal Transition of Liver Cancer Cells by Targeting miR-485-5p. +lncRNA target 34512545 hsa-mir-1a Diabetic Nephropathies In summary, Sp1 induced lncRNA Rmrp could drive the expression of JunD via sponging miR-1a-3p in DN progression. +circRNA target 34512369 hsa-mir-942 Arthritis, Rheumatoid 5p may participate in the pathogenesis of RA through disordered Cullin 4B (CUL4B) and the traditional Chinese medicine compound Huangqin Qingre Chubi Capsule (HQC) may inhibit the pathogenesis of RA through the CUL4B/Wnt pathway. +circulation_biomarker_diagnosis_up 34512173 hsa-mir-23b Hypoxia-Ischemia, Brain As per our findings, miR-23b was upregulated in the serum of IBI patients and OGD-treated murine primary neurons. Collectively, downregulated miR-23b by c-Myc might alleviate IBI by upregulating Nrf2. +exosome 34512170 hsa-mir-19a Pancreatic Carcinoma These results indicated that exosomes might be an important mediator in the pathogenesis of PaC-DM, and miR-19a might be the effector molecule. +lncRNA target 34512159 hsa-mir-877 Urinary Bladder Neoplasms Taken together, TQ induces the apoptosis through upregulating ROS level and impairing autophagic flux, and inhibiting the EMT and cell invasion via activating the miR +genetics_knock down_promote 34512151 hsa-mir-214 Glomerulonephritis, IGA Functionally, knockdown of miR +lncRNA target 34512021 hsa-mir-1229 Colorectal Neoplasms CONCLUSION: circTADA2A suppressed cell proliferation and migration in CRC through regulation of miR-1229/BCL2L10 axis, which suggested that circTADA2A might represent a novel potential target for the treatment of CRC. +other 34512002 hsa-mir-501 Ovarian Neoplasms 3p expression is significantly associated with poor survival in OC patients. +other 34511938 hsa-mir-455 Colorectal Neoplasms To our knowledge, BCL2L12 and related molecules including hsa-miR-455 and hsa-miR-125a were firstly identified as potential biomarkers in the progression from adenoma to adenocarcinoma. +other 34511938 hsa-mir-125a Colorectal Neoplasms To our knowledge, BCL2L12 and related molecules including hsa-miR-455 and hsa-miR-125a were firstly identified as potential biomarkers in the progression from adenoma to adenocarcinoma. +target gene 34511937 hsa-mir-519b Colorectal Neoplasms Long Non-Coding RNA Duxap8 Facilitates Cell Proliferation and Induces Apoptosis in Colorectal Cancer via miR-519b/ZNF277 Axis. +circRNA target 34511934 hsa-mir-370 Colorectal Neoplasms Moreover, circIFT80 inhibited the expression of hsa-miR +transcription factor target 34511489 hsa-mir-638 Osteosarcoma The functions of hsa-miR-638 and target mRNAs for the development of lung metastasis in OS could be confirmed by quantitative Real-time PCR analysis. +genetics_overexpression_promote 34511434 hsa-mir-1 Subarachnoid Hemorrhage In the SAH rat model, overexpressing circARF3 improved BBB integrity and neurological score, decreased neuronal apoptosis and microglial activation in ipsilateral basal cortex, with declined miR +lncRNA target 34511356 hsa-mir-34a Squamous Cell Carcinoma of Head and Neck MiR-34a-5p was a target of LINC01123, and its inhibitor could reverse the effect of silenced LINC01123 on the progression of OSCC. +genetics_overexpression_promote 34511042 hsa-mir-24 Lung Neoplasms 3p overexpression inhibited the proliferation and promoted the apoptosis of lung cancer cells. +lncRNA target 34511037 hsa-mir-380 Non-alcoholic Fatty Liver Disease LRP2 was confirmed to be the target gene of miR +circulation_biomarker_diagnosis_down 34511033 hsa-mir-378b Colorectal Neoplasms The expression of CDKN2B-AS1, microRNA (miR)-378b, and cytoplasmic activation/proliferation-associated protein 2 (CAPRIN2) was analyzed in CRC patients and cell lines. +lncRNA target 34511023 hsa-mir-26a Squamous Cell Carcinoma of Head and Neck Sevoflurane use to target miR-26a/FOXO1 may be a novel alternative for LSCC therapy. +genetics_knock down_promote 34510683 hsa-mir-425 Alzheimer Disease We tested the hypothesis that miR-425 loss correlates with enhanced levels of mRNA targets downstream, supporting APAM and AD progression. +genetics_GWAS 34510374 hsa-mir-7-1 Ischemic Stroke The results of this study show that the rs6736 polymorphism in the 3'-untranslated region of the C14orf119 gene not only is associated with IS but also modifies the binding between miR +transcription factor target 34510318 hsa-mir-27a Breast Neoplasms Lysophosphatidic acid receptor 6 regulated by miR-27a-3p attenuates tumor proliferation in breast cancer. CONCLUSION LPAR6 acts as a tumor suppressor in breast cancer and is positively regulated by miR-27a-3p. +genetics_overexpression_promote 34509805 hsa-mir-183 Osteoporosis CONCLUSION: MiR-183 was up-regulated in osteoporosis, and miR-183 overexpression can inhibit osteoblast differentiation by targetedly down-regulating TGF-beta pathway member Smad4 to trigger osteoporosis. +circulation_biomarker_diagnosis_up 34509791 hsa-mir-486 Obesity 5p gene expression in the prediction of obesity was 0.44 with AUC 0.736 that has a sensitivity 60% and specificity 90%, CONCLUSION: The serum level of the miR +circulation_biomarker_diagnosis_up 34509791 hsa-mir-486 Fatty Liver 5p gene expression in the prediction of obesity was 0.44 with AUC 0.736 that has a sensitivity 60% and specificity 90%, CONCLUSION: The serum level of the miR +lncRNA target 34509500 hsa-mir-876 Colonic Neoplasms 3p showed significant inhibitory effects on cell proliferation, migration, and invasion, indicating its tumor suppressor role in the progression of colon cancer. +exosome 34509269 hsa-mir-129 Cognition Disorders After treatment with Dex, miR-129 expression was elevated in brain tissues, and the neuroprotection of Dex on POCD rats was partially annulled after injection of miR-129 antagomir. In summary, Dex ameliorated SEV-induced POCD by elevating miR-129 and inhibiting TLR4 and NF-kappaB p65 phosphorylation. +other 34509164 hsa-mir-20a Pulmonary Fibrosis The results found that lung tissue fibrosis, Cd content significantly increased, lung tissue ion disturbance, miR-20a-3p down-regulation, M1/M2 imbalance, LXA4/FPR2 content decreased, MDA content increased, NF-kappaB/NLRP3, TGFbeta pathway, PPARgamma/Wnt pathway activated, and the expression of fibrosis-related factors increased. +other 34509057 hsa-mir-1 Arrhythmias, Cardiac Furthermore, the expression of miR-133b was shown to distinguish patients with SVa and Va from the arrhythmia-free controls (AUC = 0.7273, p = 0.07 and AUC = 0.8030, p = 0.04, respectively). +other 34509057 hsa-mir-133b Arrhythmias, Cardiac CONCLUSIONS: miR-1, miR-133a, and miR-133b have the potential to become diagnostic biomarkers of arrhythmia in pediatric patients. +other 34509057 hsa-mir-133a Arrhythmias, Cardiac The aim of this study was to determine whether miR-1, miR-133a, and miR-133b can serve as biomarkers in the diagnosis of ventricular (Va) and supraventricular (SVa) arrhythmias in pediatric patients. +other 34508910 hsa-mir-519a Parkinson Disease RESULTS: NEAT1 and SP1 expressions were significantly upregulated, whereas miR-519a-3p was downregulated in MPP(+)-treated neuroblastoma cells in a dose- and time-dependent manner when compared with control groups. CONCLUSIONS: NEAT1 silencing protected against MPP(+)-induced neuroblastoma cell injury by regulating the miR-519a-3p/SP1 pathway. +genetics_overexpression_promote 34508764 hsa-mir-221 Colorectal Neoplasms 3p overexpression, showing the importance of EVs-derived miR +genetics_overexpression_promote 34508745 hsa-mir-411 Liver Cirrhosis Drp1 overexpression abolished the inhibitory role of miR-411 in cell proliferation and fibrosis-associated factor levels in HSCs. +circulation_biomarker_diagnosis_ns 34508569 hsa-mir-181c Heart Failure CONCLUSIONS: Circulating miR-181c is a marker of the response to exercise training in HFpEF patients. +transcription factor target 34508321 hsa-mir-212 Cardiomyopathies 5p may attenuate MI by suppressing the NLRC5/VEGF/TGF-beta1/SMAD axis. +transcription factor target 34508321 hsa-mir-212 Myocardial Infarction 5p may attenuate MI by suppressing the NLRC5/VEGF/TGF-beta1/SMAD axis. +other 34508256 hsa-mir-16 Fetal Growth Retardation RESULTS: Raw C(t) values of miR5p were similar between SGA and AGA births (P = 0.140) and between male and female births within SGA (P = 0.159) and AGA (P = 0.060) births while that of RNU44 and RNU48 were higher in SGA births (P = 0.008 and 0.006 respectively) and in male births within the SGA group (P = 0.005) for RNU44 and in female births within the AGA group (P = 0.048) for RNU48. +other 34508256 hsa-mir-16 Alopecia RESULTS: Raw C(t) values of miR5p were similar between SGA and AGA births (P = 0.140) and between male and female births within SGA (P = 0.159) and AGA (P = 0.060) births while that of RNU44 and RNU48 were higher in SGA births (P = 0.008 and 0.006 respectively) and in male births within the SGA group (P = 0.005) for RNU44 and in female births within the AGA group (P = 0.048) for RNU48. +lncRNA target 34507637 hsa-mir-4651 Nasopharyngeal Carcinoma Therefore, HOXC-AS1/miR-4651/FOXO6 may form a competing endogenous RNA (ceRNA) network that promotes NPC progression. In conclusion, our study demonstrates that HOXC-AS1 promotes NPC progression by sponging miR-4651 and regulating FOXO6 expression, thus providing potential pharmaceutical targets for developing new NPC treatments. +other 34507619 hsa-mir-199a Hyperpigmentation, Skin RT-PCR, western blot, melanin content analysis and luciferase activity assay were used to determine the hypopigmentation of miR-181a-5p and miR-199a. +other 34507619 hsa-mir-181a Hyperpigmentation, Skin RT-PCR, western blot, melanin content analysis and luciferase activity assay were used to determine the hypopigmentation of miR-181a-5p and miR-199a. +tissue_expression_ns 34507595 hsa-mir-31 Ovarian Neoplasms CONCLUSION: In conclusion, hsa_circ_0004712 deficiency repressed OC development by mediating the miR3p/FZD4 pathway, predicting that hsa_circ_0004712 was a promising biomarker for OC diagnosis and therapy. +other 34507247 hsa-mir-199a Primary Graft Dysfunction With time, the RAI score increased gradually, and the difference of miR-199a-3p expression gradually increased (rs = 0.92, p < 0.001), suggesting that it may be related to acute rejection. CONCLUSION: miR-199a-3p might be an early warning marker for acute rejection after liver transplantation in rats. +lncRNA target 34506963 hsa-mir-21 Hemangioma, Infantile CONCLUSIONS To the best of our knowledge, the present study has, for the first time, revealed downregulation of miR-21 in VMs, which might contribute to decreased collagen expression via the TGF-/Smad3/miR-21 signaling feedback loop. +exosome 34506494 hsa-mir-122 Liver Cirrhosis CONCLUSION: Exosomal miR-122 may serve as a useful non-invasive biomarker for liver fibrosis, especially in patients with non-viral etiologies of chronic liver disease. +other 34506226 hsa-mir-155 Aging, Premature Hsa-miR5p might be the mediator in linking cellular senescence to vascular aging and atherosclerosis. +lncRNA target 34505723 hsa-mir-18a Myocardial Infarction These data for the first time suggest that lncRNA CASC2 have better protective effects on AMI, which could reduce oxidative stress through their carried miR-18a and subsequently downregulating the SIRT2/ROS pathway. +circulation_biomarker_prognosis_ns 34505413 hsa-mir-342 Parathyroid Neoplasms CONCLUSIONS: Serum miRNA3p could be a promising biomarker for PC to improve diagnosis and prognosis. +other 34504842 hsa-mir-1471 Stomach Neoplasms Overall, the circITGA7/miR-1471/MTDH signaling pathway may play a crucial role in GC, providing a new potential mechanism involved in GC progression. +other 34504813 hsa-mir-26a Neonatal Sepsis Conclusion: A lower baseline miR-26a expression in PBMCs indicated the occurrence of early-onset neonatal sepsis, and a reduced miR-26a expression might be partly related to the inflammatory process and PTEN upregulation. +genetics_knock down_suppress 34504639 hsa-mir-34 Endometritis Thus, the knockdown of miR-34a might be a new direction for the treatment of endometritis. +genetics_knock down_suppress 34504639 hsa-mir-34a Endometritis Thus, the knockdown of miR-34a might be a new direction for the treatment of endometritis. +other 34504621 hsa-mir-223 Esophageal Fibrosis 5p. +other 34504621 hsa-mir-21 Esophageal Fibrosis 5p. +other 34504621 hsa-mir-218 Esophageal Fibrosis 5p. +other 34504617 hsa-mir-124 Intracranial Aneurysm Overall, the present study demonstrated that miR5p could prevent the occurrence and development of cerebral aneurysm by downregulating the expression of FoxO1. +target gene 34504608 hsa-mir-184 Prostatic Neoplasms miR-184 delays cell proliferation, migration and invasion in prostate cancer by directly suppressing DLX1. +transcription factor target 34504602 hsa-mir-144 Glioma 3p suppressed BCL6 expression by targeting the 3'-UTR sequence of BCL6. +genetics_overexpression_suppress 34504600 hsa-mir-1269a Colorectal Neoplasms circASS1 overexpression inhibits the proliferation, invasion and migration of colorectal cancer cells by regulating the miR-1269a/VASH1 axis. +other 34504593 hsa-mir-29 Cerebral Infarction In conclusion, the results of the present study suggested that SNHG1 may reduce microglial cell activity by regulating the expression of miR3p, indicating its potential protective role in cerebral infarction. +genetics_knock down_suppress 34504588 hsa-mir-506 Pancreatic Neoplasms Knockdown of LINC00657 inhibits the viability, migration and invasion of pancreatic cancer cells by regulating the miR-520h/CKS1B axis. +target gene 34504582 hsa-mir-221 Precursor Cell Lymphoblastic Leukemia-Lymphoma MicroRNA-221 regulates cell activity and apoptosis in acute lymphoblastic leukemia via regulating PTEN. +circRNA target 34504560 hsa-mir-145 Osteosarcoma In summary, circ_0008932 may be a novel oncogenic factor during the progression and development of OS by targeting miR +transcription factor target 34504558 hsa-mir-328a Cranial Nerve Injuries miR-328a-3p was differentially expressed in peripheral nerve stumps after nerve injury. Collectively, the present study demonstrated that dysregulated miR-328a-3p after peripheral nerve injury may affect the migration and angiogenesis of endothelial cells and contribute to peripheral nerve regeneration. +transcription factor target 34504558 hsa-mir-328a Peripheral Nerve Injuries Collectively, the present study demonstrated that dysregulated miR-328a-3p after peripheral nerve injury may affect the migration and angiogenesis of endothelial cells and contribute to peripheral nerve regeneration. +other 34504555 hsa-mir-483 Cerebrovascular Disorders 5p expression may be a candidate biomarker for ACAS diagnosis and the prediction of cerebrovascular event occurrence. +other 34504555 hsa-mir-483 Carotid Stenosis 5p expression may be a candidate biomarker for ACAS diagnosis and the prediction of cerebrovascular event occurrence. +lncRNA target 34504547 hsa-mir-7 Breast Neoplasms TGFBR2-Smad3-CD44 regulatory axis was highly efficient in the inhibition of CD44 expression in BCSCs, and that the regulatory expression of ALDH1A3 and miR-7 may provide a strategy in the therapy of breast cancer. +lncRNA target 34504167 hsa-mir-642a Wilms Tumor Taken together, these data provide insight into the molecular mechanisms by which miR-642a-5p acts as a tumor suppressor in PCa, an effect partially mediated by regulating genes involved in cell cycle control; and restoration of miR +lncRNA target 34504167 hsa-mir-642a Prostatic Neoplasms Taken together, these data provide insight into the molecular mechanisms by which miR-642a-5p acts as a tumor suppressor in PCa, an effect partially mediated by regulating genes involved in cell cycle control; and restoration of miR +lncRNA target 34504061 hsa-mir-508 Lung Neoplasms 5p elevation inhibited proliferation, migration, and invasion of LC cells and promoted LC cell apoptosis, and also suppressed the in vivo tumor growth. +lncRNA target 34503538 hsa-mir-206 Pituitary Neoplasms It starts from the study of whether miRNA, miRNA-26b, miRNA-138, miRNA-206, and miRNA-let-7e may be tumor suppressor genes in NFPA, which provides a basis for further exploration of tumor markers of pituitary adenoma. +lncRNA target 34503538 hsa-let-7e Pituitary Neoplasms It starts from the study of whether miRNA, miRNA-26b, miRNA-138, miRNA-206, and miRNA-let-7e may be tumor suppressor genes in NFPA, which provides a basis for further exploration of tumor markers of pituitary adenoma. +lncRNA target 34503538 hsa-mir-26b Pituitary Neoplasms It starts from the study of whether miRNA, miRNA-26b, miRNA-138, miRNA-206, and miRNA-let-7e may be tumor suppressor genes in NFPA, which provides a basis for further exploration of tumor markers of pituitary adenoma. +lncRNA target 34503538 hsa-mir-138 Pituitary Neoplasms It starts from the study of whether miRNA, miRNA-26b, miRNA-138, miRNA-206, and miRNA-let-7e may be tumor suppressor genes in NFPA, which provides a basis for further exploration of tumor markers of pituitary adenoma. +lncRNA target 34503528 hsa-mir-4721 Nasopharyngeal Carcinoma We found that miR-4721, FOXA1 and Nanog control their expressions through a negative feedback loop and then activate the downstream regulator of stem cell signaling to promote the enrichment and metastasis of NPC stem cells. +genetics_knock down_promote 34503521 hsa-mir-193 Sepsis Knockdown STAT3 reversed the role of inhibited miR +genetics_knock down_promote 34503521 hsa-mir-193 Cardiomyopathies Knockdown STAT3 reversed the role of inhibited miR +tissue_expression_ns 34503396 hsa-mir-155 Multiple Sclerosis It is possible that miR-146a may be associated with vitamin D deficiency and disease disability, while miR-155 may be associated with the number of attacks. +tissue_expression_ns 34503396 hsa-mir-146a Multiple Sclerosis It is possible that miR-146a may be associated with vitamin D deficiency and disease disability, while miR-155 may be associated with the number of attacks. +other 34503175 hsa-mir-22 Multiple Myeloma Results: We found an inverse correlation between MYC and miR-22 expression, which is associated with poor outcome in IMiD-treated MM patients. Conclusions: Taken together, our findings indicate that: (1) low miR-22 expression could represent a potential predictive biomarker of poor lenalidomide response in MM patients; and (2) miR-22 reduces MYC oncogenic activity, thus triggering a novel synthetic lethality loop, which sensitizes MM cells to lenalidomide. +circulation_biomarker_diagnosis_ns 34503070 hsa-mir-371a Neoplasms, Germ Cell and Embryonal The miR-371a-3 cluster members are an example, monitoring the presence of malignant germ cell tumors based on patient serum/plasma analyses. +other 34502497 hsa-mir-34 Colorectal Neoplasms In The Cancer Genome Atlas (TCGA) samples, we also found genome-wide ceRNA gene sets regulated by miR-34a and miR-200 in colorectal cancer. +other 34502497 hsa-mir-200 Colorectal Neoplasms In The Cancer Genome Atlas (TCGA) samples, we also found genome-wide ceRNA gene sets regulated by miR-34a and miR-200 in colorectal cancer. +other 34502497 hsa-mir-34a Colorectal Neoplasms In The Cancer Genome Atlas (TCGA) samples, we also found genome-wide ceRNA gene sets regulated by miR-34a and miR-200 in colorectal cancer. +tissue_expression_ns 34502449 hsa-mir-408 Avitaminosis Cu-miRNAs, such as miR398 and miR408 are conserved, as well as the signal transduction pathway to induce them under Cu deficiency. +tissue_expression_ns 34502449 hsa-mir-98 Avitaminosis Cu-miRNAs, such as miR398 and miR408 are conserved, as well as the signal transduction pathway to induce them under Cu deficiency. +other 34502341 hsa-mir-1885 Clubfoot The Bra-miR1885-mediated down-regulation of both genes was detected for up to 15 days post-inoculation in the clubroot-resistant line CR Shinki and in the clubroot-susceptible line 94SK. +genetics_overexpression_suppress 34502294 hsa-mir-24 immunodeficiency 35 3p overexpression, and further offset the effects of miR +other 34502118 hsa-mir-497 Burns Moreover, we identified miR5p as stably downregulated in tissue and dISF in the early phase after a burn injury. +exosome 34500436 hsa-mir-185 Carcinoma, Non-Small-Cell Lung 5p inhibits tumor cell-derived exosomes-mediated proliferation, migration and invasion of NSCLC cells by downregulating RAB35 expression. +lncRNA target 34500373 hsa-mir-3150b Carcinoma, Non-Small-Cell Lung CONCLUSIONS: LncRNA RP11-116G8.5 promotes malignant behaviors of LUSC through sponging miR-3150b-3p/miR +lncRNA target 34500373 hsa-mir-6870 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: LncRNA RP11-116G8.5 promotes malignant behaviors of LUSC through sponging miR-3150b-3p/miR +lncRNA target 34499929 hsa-mir-2355 Lymphoma, B-Cell 5p to regulate ATG5, revealing a novel molecular mechanism of ARRDC1-AS1 in DLBCL and suggested ARRDC1-AS1 as a potential target in DLBCL. +epigenetics 34499308 hsa-mir-192 Colorectal Neoplasms CONCLUSIONS: It seems that MIR192-2 promoter hypermethylation might regulate the expression of SOX4 and therefore modulate metastasis in CRC. +lncRNA target 34499009 hsa-mir-363 Stomach Neoplasms The mechanism of circ0005654 on miR-363/specificity protein 1 (sp1) axis was evaluated in GC cells by bioinformatics analysis, luciferase reporter, FISH, and ChIP assays. In conclusion, circ0005654 expedites the GC development via miR-363/sp1/myc/Wnt/beta-catenin axis and is a new biomarker for GC treatment regimen. +other 34499007 hsa-mir-493 Uterine Cervical Neoplasms The expression of CCAT2, the miR5p microRNA (miRNA), and mRNA was detected using qRT-PCR. +circRNA target 34499003 hsa-mir-495 Dehydration In conclusion, circ-UQCRC2 contributed to LPS-induced injury of 16HBE cells by targeting miR3p/MYD88 signalling-mediated inflammatory response and oxidative stress. +other 34498815 hsa-mir-486a Xerostomia CONCLUSIONS: Radiation was found to induce damage of the submandibular gland and affect Cdkn1a expression by regulating the expression of miR-486a-3p in a xerostomia murine model. Therefore, modulation of miR-486a-3p and the Cdkn1a gene in a xerostomia murine model might improve damage of the submandibular gland. +other 34498720 hsa-mir-199 Glioblastoma In conclusion, the findings of the present study identified novel roles for circFLNA in GBM and indicated that the circFLNA/miR1993p signaling axis may serve an important role in GBM progression. +lncRNA target 34498716 hsa-mir-451a Carcinoma, Hepatocellular An understanding of the competing endogenous RNA network of ZSCAN16AS1/miR451a/ATF2 in HCC might be instrumental in the development of attractive targets for molecular therapy. +other 34498713 hsa-mir-4792 Meningitis, Cryptococcal In addition, following antifungal treatment in patients with cryptococcal meningitis, the levels of miR4792 in the cerebrospinal fluid significantly increased, whilst the expression of EGFR significantly decreased. In addition, receiver operator characteristic analysis revealed miR4792 (AUC(ROC)=0.75) and EGFR (AUC(ROC)=0.79) as potential diagnostic markers in patients with cryptococcal meningitis. +transcription factor target 34498712 hsa-mir-221 Fibrosis The expression of miR221 was quantified in a liver fibrosis model in vivo and in vitro, and its specific target gene lysosomeassociated membrane glycoprotein 2 (LAMP2) was predicted by bioinformatics. +genetics_overexpression_promote 34498707 hsa-mir-133a Sepsis Compared with the control group, the expression of FGD5AS1 was decreased and the expression of miR133a3p was increased in the sepsis group. These results indicated that FGD5AS1 is the competitive endogenous RNA of miR133a3p on AQP1, and thus FGD5AS1 overexpression may be able to inhibit the inflammatory response in sepsis. +genetics_overexpression_promote 34498706 hsa-mir-1281 Colorectal Neoplasms Furthermore, LINC00963 overexpression plasmid, LINC00963 small interfering RNA, miR1281 mimics or miR1281 inhibitors were transfected into CRC cells, and Cell Counting Kit8, colony formation and Transwell assays were adopted to study the effects of LINC00963 and miR1281 on the malignant phenotypes of CRC cells. +lncRNA target 34498594 hsa-mir-130a Atherosclerosis CONCLUSION: These results strongly support that miRNA-130a suppression can protect against atherosclerosis through inhibiting inflammation by regulating the PPARgamma/ NF-kappaB expression. +transcription factor target 34498538 hsa-mir-1 Esophageal Neoplasms Collectively, the current study demonstrated that Que exerted inhibitory effects on EC cells by inducing miR +circulation_biomarker_prognosis_ns 34497895 hsa-mir-181a Ovarian Neoplasms Objective: To determine the possibility of early diagnosis and prognosis of ovarian cancer (OC) via detecting miR-181a in circulating tumor cells (CTCs) of OC and to solve clinical difficulties in OC tissue sample collection. +genetics_overexpression_promote 34497853 hsa-mir-29c Melanoma CONCLUSION: Overexpression of miR-29c-3p suppresses CDCA4 expression and decreases proliferation, migration, invasion, apoptosis, and EMT of MM cells, thus hindering MM progression. +other 34497805 hsa-mir-23b Parkinson Disease Additionally, miR-23b-3p was identified as a novel direct regulator of alpha-synuclein, which is possibly the key component in PD. +other 34497755 hsa-mir-142 Adenocarcinoma of Lung 5p/GOLPH3 affected overall survival of LUAD patients. +other 34497682 hsa-mir-18a Lung Diseases Thus, we have not only established a rat model for lung IR and enumerated the important miRNAs involved in IR but have also extensively characterized the role of miR-18a-5p. +other 34497524 hsa-mir-1 Osteoarthritis, Knee In addition, knee OA-related key miRNAs such as miR-101, miR-181a, miR-29, miR-9, and miR-221, and pathways such as Wnt signaling, HIF-1 signaling, PI3K-Akt signaling, and axon guidance pathways were also identified. Among above identified knee OA-related key genes, pathways and miRNAs, genes such as AHR, HEY1, MYC, GAP43, and PTN, pathways like axon guidance, and miRNAs such as miR-17, miR-21, miR-155, miR-185, and miR-1 are lack of research and worthy for future investigation. +lncRNA target 34497517 hsa-mir-221 Seizures 3p/HIF-1alpha as essential component in pathogenesis of VPA-resistant epilepsy which represent therapeutic antiseizure targets. +lncRNA target 34497517 hsa-mir-221 Drug Resistant Epilepsy 3p/HIF-1alpha as essential component in pathogenesis of VPA-resistant epilepsy which represent therapeutic antiseizure targets. +circulation_biomarker_diagnosis_up 34497505 hsa-mir-342 Alzheimer Disease 5p in plasma were associated with faster cognitive decline in patients with mild AD after 2 years of follow-up. +target gene 34497267 hsa-mir-1246 Ovarian Neoplasms METTL3 promotes the initiation and metastasis of ovarian cancer by inhibiting CCNG2 expression via promoting the maturation of pri-microRNA-1246. +circulation_biomarker_diagnosis_ns 34497265 hsa-mir-3157 Carcinoma, Non-Small-Cell Lung 3p is involved in the formation of pre-metastatic niche formation before tumor metastasis and may be used as a blood-based biomarker for NSCLC metastasis. +lncRNA target 34497156 hsa-mir-28 Carcinoma, Renal Cell SNHG17/miR3p/H2AXaxis might be involved in RCC progression, which provided a potential therapeutic target for RCC. +lncRNA target 34497040 hsa-mir-372 Carcinoma, Hepatocellular 3p via PART1 delivery to promote macrophage M2 polarization in HCC. +lncRNA target 34496842 hsa-mir-149 Esophageal Squamous Cell Carcinoma In addition, colony formation and invasion assays verified that GACAT3 promotes ESCC tumor progression through miR-149. CONCLUSIONS: These findings indicate that GACAT3 functions as an oncogene by acting as a ceRNA for miR-149 to modulate FOXM1 expression in ESCC, suggesting that GACAT3 might constitute a therapeutic target in ESCC. +lncRNA target 34496838 hsa-mir-422a Colorectal Neoplasms CONCLUSIONS: LINC00958 promoted MAPK1 expression and cell proliferation and suppressed cell apoptosis and radiosensitivity by targeting miR-422a, which suggests that it is a potential biomarker for the prognosis and treatment of colorectal cancer. +genetics_overexpression_promote 34496829 hsa-mir-611 Adenocarcinoma of Lung Subsequently, rescue experiments delineated that miR-3611 downregulation or FOXP3 overexpression reversed the effects of silenced LINC00520 on proliferative and migratory capabilities in LUAD cells. +genetics_knock down_promote 34496800 hsa-mir-140 Ovarian Neoplasms 3p overexpression suppressed the viability, proliferation and invasion of ovarian cancer cells. +lncRNA target 34496750 hsa-mir-935 Diabetes Mellitus Targeted inhibition of miR-504 and miR-935 could reverse the high-glucose-induced testicular complications, thus posing as a potential therapeutic approach in diabetic testicular injury. +lncRNA target 34496750 hsa-mir-504 Diabetes Mellitus Targeted inhibition of miR-504 and miR-935 could reverse the high-glucose-induced testicular complications, thus posing as a potential therapeutic approach in diabetic testicular injury. +lncRNA target 34496413 hsa-mir-519d Thyroid Cancer, Papillary MiR-519d-3p may be a tumor-inhibiting miRNA in PTC, and that miR-519d-3p/FOXQ1 axis mediated PTC tumor progression from cell proliferation, migration, and invasion in PTC cells. +lncRNA target 34496364 hsa-mir-181b Inflammation CONCLUSION: SNHG1 was involved in LPS-induced microglial activation and inflammation response via targeting miR-181b, providing another evidence of the roles of SNHG1 implicated in neuroinflammation of microglia. +lncRNA target 34496364 hsa-mir-181b Neurogenic Inflammation INTRODUCTION: Long noncoding RNA small nuclear host gene 1 (SNHG1) was involved in neuroinflammation in microglial BV-2 cells; however, its interaction with microRNA (miR)-181b in lipopolysaccharide (LPS)-induced BV-2 cells remained poor. CONCLUSION: SNHG1 was involved in LPS-induced microglial activation and inflammation response via targeting miR-181b, providing another evidence of the roles of SNHG1 implicated in neuroinflammation of microglia. +lncRNA target 34496348 hsa-mir-92a Stomach Neoplasms CONCLUSION: Thus, we concluded that PITPNA-AS1 induced the development of GC cells by inhibiting miR-92a-3p and inducing SOX4. +other 34495821 hsa-mir-526b Reperfusion Injury, Cerebral Ischemia Eventually, the promoting role of the circ_0062166/miR-526b-5p/BCL2L13 axis in the CIR injury was verified. CONCLUSION: To sum up, the present study has demonstrated that circ_0062166/miR-526b-5p/BCL2L13 axis accelerated the progression of CIR injury, which might provide effective strategies for CIR injury therapy. +circulation_biomarker_diagnosis_ns 34495485 hsa-mir-124 Atrial Fibrillation In conclusion, these findings suggested that circulating exosomal miRNAs may serve as novel biomarkers for AF, and miR +transcription factor target 34495404 hsa-mir-17 Depression Overall, our findings indicated that Nrf2 inhibited miR5p expression and promoted Wfs1 transcription, thereby alleviating cognitive dysfunction and inflammatory injury in rats with depression-like behaviors. +circulation_biomarker_diagnosis_ns 34495394 hsa-mir-16 Breast Neoplasms In addition, the proposed electrochemical biosensor capable for the simultaneous detection of miRNA-155, miRNA-16, and miRNA-21, which are breast cancer biomarkers, in normal human serum, can be adopted and potentially used for breast cancer screening. +circulation_biomarker_diagnosis_ns 34495394 hsa-mir-21 Breast Neoplasms In addition, the proposed electrochemical biosensor capable for the simultaneous detection of miRNA-155, miRNA-16, and miRNA-21, which are breast cancer biomarkers, in normal human serum, can be adopted and potentially used for breast cancer screening. +circulation_biomarker_diagnosis_ns 34495394 hsa-mir-155 Breast Neoplasms In addition, the proposed electrochemical biosensor capable for the simultaneous detection of miRNA-155, miRNA-16, and miRNA-21, which are breast cancer biomarkers, in normal human serum, can be adopted and potentially used for breast cancer screening. +lncRNA target 34495369 hsa-mir-340 Corneal Neovascularization 5p mediates the therapeutic effect of MSCs on CNV via binding and repressing the expressions of EMP2 and PROX1. +circulation_biomarker_diagnosis_up 34495077 hsa-mir-195 Diabetes Mellitus, Type 2 5p circulating in the peripheral blood served as a novel biomarker and therapeutic target for EH and T2DM, which could eventually help address major challenges during the diagnosis and treatment of EH and T2DM. +circulation_biomarker_diagnosis_up 34495077 hsa-mir-195 Essential Hypertension 5p circulating in the peripheral blood served as a novel biomarker and therapeutic target for EH and T2DM, which could eventually help address major challenges during the diagnosis and treatment of EH and T2DM. +other 34494941 hsa-mir-532 Carcinoma, Non-Small-Cell Lung 3p/FOXR2 network. +other 34494934 hsa-mir-146a Osteoarthritis The expressions of TrkA, TrkB and ShcB and NEAT1 were up-regulated in OA and IL-1beta-stimulated chondrocytes, while miR-146a-3p was donwnregulated and was negatively correlated with TrkB or NEAT1. +other 34494412 hsa-mir-140 Tendon Injuries Modulation of the H19/miR5p/VEGFA axis in TDSCs is a new potential strategy for clinical treatment of tendon injury. +other 34494305 hsa-mir-125a Stomach Neoplasms Long non-coding RNA TNK2 AS1/microRNA-125a-5p axis promotes tumor growth and modulated phosphatidylinositol 3 kinase/AKT pathway. +transcription factor target 34493899 hsa-mir-143 Pneumonia Therefore, miR3p is considered a potential molecular target for the treatment of lung inflammation. +transcription factor target 34493702 hsa-mir-199a Arteriosclerosis In vivo experiments confirmed that EPC-EVs inhibited ferroptosis of endothelial cells and then alleviated the occurrence of AS via the miR-199a-3p/SP1 axis. To conclude, EPC-EVs transferred miR-199a-3p to inhibit SP1, thus repressing ferroptosis of endothelial cells and retarding the occurrence of AS. +other 34493366 hsa-mir-221 Carcinoma, Ductal, Breast Higher expression of miR-221, an oncomiR that facilitates entry into the cell cycle S-phase, is regulated by c-MYC, which is expressed more in breast cancer samples from B/AA patients. +other 34493366 hsa-mir-135b Carcinoma, Ductal, Breast Furthermore, the cell migration- and invasion-promoting miRNA, miR-135b, has increased relative expression in B/AA patients. +genetics_overexpression_promote 34493358 hsa-mir-605 Carcinoma, Non-Small-Cell Lung 3p downregulation or MACC1 overexpression. +circulation_biomarker_prognosis_down 34493304 hsa-mir-935 Pneumonia, Mycoplasma RESULTS: MiR-3935 expression is significantly decreased in both placentas and peripheral blood specimens of PE, and functionally, miR-3935 promotes EMT of trophoblast cells. +lncRNA target 34493304 hsa-mir-935 Uterine Diseases CONCLUSIONS: Together these results uncover a hitherto uncharacterized role of miR-3935/TRAF6/RGS2 axis in the function of human trophoblasts, which may pinpoint the molecular pathogenesis of PE and may be a prognostic biomarker and therapeutic target for such obstetrical diseases as PE. +other 34493227 hsa-mir-528 Dehydration Network analysis revealed TCONS_00021861/miR528-3p/YUCCA7 regulatory axis as a hub involved in drought response. CONCLUSIONS: TCONS_00021861 could regulate YUCCA7 by sponging miR528-3p, which in turn activates IAA biosynthetic pathway and confer resistance to drought stress. +genetics_knock down_suppress 34493213 hsa-mir-128 Uterine Cervical Neoplasms Circ-ABCB10 knockdown inhibits the malignant progression of cervical cancer through microRNA-128-3p/ZEB1 axis. +circulation_biomarker_diagnosis_ns 34493187 hsa-mir-27b Acquired Immunodeficiency Syndrome OBJECTIVE: The aim of this cross-sectional study was to assess the expression pattern of miR-27b, -29, -150, and -221, as well as their relationship with CD4+ T-cell count, HIV-1 viral load, and nef gene expression in peripheral blood mononuclear cells (PBMCs) of untreated viremic patients and in LTNPs. +exosome 34492742 hsa-mir-21 Hemoglobinuria, Paroxysmal For the subgroup analysis, it was showed that ex-miR-21 had a superior diagnostic accuracy on identifying PC. CONCLUSION: Exosomal microRNA-21 can serve as an effective and widely used diagnostic biomarker for cancer, especially in PC. +genetics_overexpression_suppress 34492599 hsa-mir-21 Carcinoma, Non-Small-Cell Lung MicroRNA-21 (miR-21) is frequently overexpressed in various cancer types including breast and non-small cell lung cancer and its functions can be inhibited by miR inhibitor (miR-21i). +other 34492519 hsa-mir-5703 Breast Neoplasms CONCLUSION: Identification of miR-5703 and its network for Runx2 regulation directly or indirectly in breast cancer cells could significantly advance our understanding of breast cancer-mediated bone metastasis. +lncRNA target 34491827 hsa-mir-4429 Adenocarcinoma of Lung This research discovered that miR-4429 was low expressed in lung ADC cells. Consequently, miR-4429 can inactivate Wnt/beta-catenin signaling pathway by targeting beta-catenin and prevent oncogene expression in lung ADC cells. +exosome 34491386 hsa-mir-214 Rhabdoid Tumor, Kidney Exosomal miR3p expression level determined by qRT-PCR was significantly higher in RTK-derived cell lines than in the human embryonic renal cell line or NB-derived cell lines. +genetics_GWAS 34491311 hsa-mir-29a Leiomyoma Leiomyomas bearing the MED12 mutation expressed higher levels of MIAT and lower levels of microRNA 29 family (miR-29a, -b, and -c) compared with MED12 wild-type leiomyomas. In a 3-dimensional spheroid culture system, transient transfection of MIAT siRNA in leiomyoma smooth muscle cell (LSMC) spheroids resulted in upregulation of miR-29 family and downregulation of miR-29 targets, collagen type I (COL1A1), collagen type III (COL3A1), and TGF-beta3 (transforming growth factor beta-3). +transcription factor target 34490833 hsa-mir-199b Acute Kidney Injury We aimed to explore whether DMY could affect Nrf2 pathway by regulating miR-199b-3p and played a protective role in septic AKI. MiR-199b-3p was increased in septic AKI models, DMY might alleviate septic AKI by regulating miR-199b-3p to affect the Nrf2 pathway. +transcription factor target 34490709 hsa-mir-211 Urethritis parvum-infected cells and UpVF-transfected cells identified miR-211 and miR-214 as the negative regulators of the apoptotic cascade under ER stress. * UpVF triggered ER stress but suppressed apoptotic cascade via miR-211 and -214. +other 34490709 hsa-mir-214 Urethritis parvum-infected cells and UpVF-transfected cells identified miR-211 and miR-214 as the negative regulators of the apoptotic cascade under ER stress. +lncRNA target 34490480 hsa-mir-486 Stomach Neoplasms miR4865p also suppressed cell cycle process and migration and promoted apoptosis in GC cells, as verified by propidium iodide (PI) staining, Transwell assay and PI/Annexin V staining. +transcription factor target 34490081 hsa-mir-425 Colorectal Neoplasms Here, we unveil that elevated miR-425 and miR-576 promote CRLM through inhibiting PTEN-mediated cellular immune function. +transcription factor target 34490081 hsa-mir-576 Colorectal Neoplasms Here, we unveil that elevated miR-425 and miR-576 promote CRLM through inhibiting PTEN-mediated cellular immune function. +transcription factor target 34490081 hsa-mir-576 Liver Neoplasms Here, we unveil that elevated miR-425 and miR-576 promote CRLM through inhibiting PTEN-mediated cellular immune function. +transcription factor target 34490081 hsa-mir-425 Liver Neoplasms Here, we unveil that elevated miR-425 and miR-576 promote CRLM through inhibiting PTEN-mediated cellular immune function. +other 34490028 hsa-let-7g Hamartoma Syndrome, Multiple 5p in the hippocampus and CBL and PVRL1 in the hypothalamus. +other 34490028 hsa-mir-19b Hamartoma Syndrome, Multiple 5p in the hippocampus and CBL and PVRL1 in the hypothalamus. +other 34490028 hsa-mir-125a Hamartoma Syndrome, Multiple 5p in the hippocampus and CBL and PVRL1 in the hypothalamus. +other 34490028 hsa-mir-194a Hamartoma Syndrome, Multiple 5p in the hippocampus and CBL and PVRL1 in the hypothalamus. +other 34490028 hsa-mir-7-1 Hamartoma Syndrome, Multiple 5p in the hippocampus and CBL and PVRL1 in the hypothalamus. +circRNA target 34489401 hsa-mir-223 Gallbladder Neoplasms Mechanistic analysis further highlighted that circbeta-catenin promoted Stathmin 1 (STMN1) expression through sponging miR-223 in GBC progression. In summary, our findings indicated that circbeta-catenin/miR-223/STMN1 axis could regulate cell growth and Warburg effect in GBC. +other 34489228 hsa-mir-26a-1 Asthma 3p and hsa-miR-376a-3p could be used to differentiate between eosinophilic and noneosinophilic asthma. +other 34489228 hsa-mir-376a Asthma 3p and hsa-miR-376a-3p could be used to differentiate between eosinophilic and noneosinophilic asthma. +genetics_knock down_suppress 34489160 hsa-mir-181a Inflammation Furthermore, the regulatory effects of MIAT knockdown in cell proliferation, apoptosis, and inflammatory injury was reversed by inhibition of miR-181a-5p or overexpression of JAK2 in OGD-treated HCM. +genetics_knock down_suppress 34489160 hsa-mir-181a Myocardial Ischemia CONCLUSION: MIAT knockdown inhibited apoptosis and inflammation by regulating JAK2/STAT3 signaling pathway via targeting miR-181a-5p in myocardial ischemia model. +genetics_GWAS 34488676 hsa-mir-126 Cervical Intraepithelial Neoplasia METHODS: Ten single-nucleotide polymorphisms (SNPs) in the miR-21, miR-26b, miR-221/222 and miR-126 genes (rs1292037, rs13137 in miR-21; rs2227255, rs2227258 in miR-26b; rs2858061, rs34678647, rs2858060, rs2745709 in miR-221/222; rs2297537, rs2297538 in miR-126) were selected, and genotyped in a total of 2176 individuals, including 435 patients with cervical intraepithelial neoplasia (CIN), 743 patients with cervical cancer (CC) and 998 healthy persons using TaqMan assays, and their associations with CIN and CC were evaluated. CONCLUSION: Our results indicate that rs2297538 and rs2297537 in miR-126, rs1292037 and rs13137 in miR-21, and rs2745709 in miR-221/222, may have important roles in the development of CIN or CC. +genetics_GWAS 34488676 hsa-mir-21 Cervical Intraepithelial Neoplasia METHODS: Ten single-nucleotide polymorphisms (SNPs) in the miR-21, miR-26b, miR-221/222 and miR-126 genes (rs1292037, rs13137 in miR-21; rs2227255, rs2227258 in miR-26b; rs2858061, rs34678647, rs2858060, rs2745709 in miR-221/222; rs2297537, rs2297538 in miR-126) were selected, and genotyped in a total of 2176 individuals, including 435 patients with cervical intraepithelial neoplasia (CIN), 743 patients with cervical cancer (CC) and 998 healthy persons using TaqMan assays, and their associations with CIN and CC were evaluated. CONCLUSION: Our results indicate that rs2297538 and rs2297537 in miR-126, rs1292037 and rs13137 in miR-21, and rs2745709 in miR-221/222, may have important roles in the development of CIN or CC. +genetics_GWAS 34488676 hsa-mir-126 Uterine Cervical Neoplasms METHODS: Ten single-nucleotide polymorphisms (SNPs) in the miR-21, miR-26b, miR-221/222 and miR-126 genes (rs1292037, rs13137 in miR-21; rs2227255, rs2227258 in miR-26b; rs2858061, rs34678647, rs2858060, rs2745709 in miR-221/222; rs2297537, rs2297538 in miR-126) were selected, and genotyped in a total of 2176 individuals, including 435 patients with cervical intraepithelial neoplasia (CIN), 743 patients with cervical cancer (CC) and 998 healthy persons using TaqMan assays, and their associations with CIN and CC were evaluated. CONCLUSION: Our results indicate that rs2297538 and rs2297537 in miR-126, rs1292037 and rs13137 in miR-21, and rs2745709 in miR-221/222, may have important roles in the development of CIN or CC. +genetics_GWAS 34488676 hsa-mir-221 Cervical Intraepithelial Neoplasia METHODS: Ten single-nucleotide polymorphisms (SNPs) in the miR-21, miR-26b, miR-221/222 and miR-126 genes (rs1292037, rs13137 in miR-21; rs2227255, rs2227258 in miR-26b; rs2858061, rs34678647, rs2858060, rs2745709 in miR-221/222; rs2297537, rs2297538 in miR-126) were selected, and genotyped in a total of 2176 individuals, including 435 patients with cervical intraepithelial neoplasia (CIN), 743 patients with cervical cancer (CC) and 998 healthy persons using TaqMan assays, and their associations with CIN and CC were evaluated. CONCLUSION: Our results indicate that rs2297538 and rs2297537 in miR-126, rs1292037 and rs13137 in miR-21, and rs2745709 in miR-221/222, may have important roles in the development of CIN or CC. +genetics_GWAS 34488676 hsa-mir-221 Uterine Cervical Neoplasms METHODS: Ten single-nucleotide polymorphisms (SNPs) in the miR-21, miR-26b, miR-221/222 and miR-126 genes (rs1292037, rs13137 in miR-21; rs2227255, rs2227258 in miR-26b; rs2858061, rs34678647, rs2858060, rs2745709 in miR-221/222; rs2297537, rs2297538 in miR-126) were selected, and genotyped in a total of 2176 individuals, including 435 patients with cervical intraepithelial neoplasia (CIN), 743 patients with cervical cancer (CC) and 998 healthy persons using TaqMan assays, and their associations with CIN and CC were evaluated. CONCLUSION: Our results indicate that rs2297538 and rs2297537 in miR-126, rs1292037 and rs13137 in miR-21, and rs2745709 in miR-221/222, may have important roles in the development of CIN or CC. +genetics_GWAS 34488676 hsa-mir-21 Uterine Cervical Neoplasms METHODS: Ten single-nucleotide polymorphisms (SNPs) in the miR-21, miR-26b, miR-221/222 and miR-126 genes (rs1292037, rs13137 in miR-21; rs2227255, rs2227258 in miR-26b; rs2858061, rs34678647, rs2858060, rs2745709 in miR-221/222; rs2297537, rs2297538 in miR-126) were selected, and genotyped in a total of 2176 individuals, including 435 patients with cervical intraepithelial neoplasia (CIN), 743 patients with cervical cancer (CC) and 998 healthy persons using TaqMan assays, and their associations with CIN and CC were evaluated. CONCLUSION: Our results indicate that rs2297538 and rs2297537 in miR-126, rs1292037 and rs13137 in miR-21, and rs2745709 in miR-221/222, may have important roles in the development of CIN or CC. +genetics_GWAS 34488676 hsa-mir-26b Uterine Cervical Neoplasms BACKGROUND: miR-21, miR-26b, miR-221/222 and miR-126 play crucial roles in cervical cancer development. METHODS: Ten single-nucleotide polymorphisms (SNPs) in the miR-21, miR-26b, miR-221/222 and miR-126 genes (rs1292037, rs13137 in miR-21; rs2227255, rs2227258 in miR-26b; rs2858061, rs34678647, rs2858060, rs2745709 in miR-221/222; rs2297537, rs2297538 in miR-126) were selected, and genotyped in a total of 2176 individuals, including 435 patients with cervical intraepithelial neoplasia (CIN), 743 patients with cervical cancer (CC) and 998 healthy persons using TaqMan assays, and their associations with CIN and CC were evaluated. +genetics_GWAS 34488676 hsa-mir-26b Cervical Intraepithelial Neoplasia BACKGROUND: miR-21, miR-26b, miR-221/222 and miR-126 play crucial roles in cervical cancer development. METHODS: Ten single-nucleotide polymorphisms (SNPs) in the miR-21, miR-26b, miR-221/222 and miR-126 genes (rs1292037, rs13137 in miR-21; rs2227255, rs2227258 in miR-26b; rs2858061, rs34678647, rs2858060, rs2745709 in miR-221/222; rs2297537, rs2297538 in miR-126) were selected, and genotyped in a total of 2176 individuals, including 435 patients with cervical intraepithelial neoplasia (CIN), 743 patients with cervical cancer (CC) and 998 healthy persons using TaqMan assays, and their associations with CIN and CC were evaluated. +genetics_GWAS 34488676 hsa-mir-222 Cervical Intraepithelial Neoplasia METHODS: Ten single-nucleotide polymorphisms (SNPs) in the miR-21, miR-26b, miR-221/222 and miR-126 genes (rs1292037, rs13137 in miR-21; rs2227255, rs2227258 in miR-26b; rs2858061, rs34678647, rs2858060, rs2745709 in miR-221/222; rs2297537, rs2297538 in miR-126) were selected, and genotyped in a total of 2176 individuals, including 435 patients with cervical intraepithelial neoplasia (CIN), 743 patients with cervical cancer (CC) and 998 healthy persons using TaqMan assays, and their associations with CIN and CC were evaluated. CONCLUSION: Our results indicate that rs2297538 and rs2297537 in miR-126, rs1292037 and rs13137 in miR-21, and rs2745709 in miR-221/222, may have important roles in the development of CIN or CC. +genetics_GWAS 34488676 hsa-mir-222 Uterine Cervical Neoplasms METHODS: Ten single-nucleotide polymorphisms (SNPs) in the miR-21, miR-26b, miR-221/222 and miR-126 genes (rs1292037, rs13137 in miR-21; rs2227255, rs2227258 in miR-26b; rs2858061, rs34678647, rs2858060, rs2745709 in miR-221/222; rs2297537, rs2297538 in miR-126) were selected, and genotyped in a total of 2176 individuals, including 435 patients with cervical intraepithelial neoplasia (CIN), 743 patients with cervical cancer (CC) and 998 healthy persons using TaqMan assays, and their associations with CIN and CC were evaluated. CONCLUSION: Our results indicate that rs2297538 and rs2297537 in miR-126, rs1292037 and rs13137 in miR-21, and rs2745709 in miR-221/222, may have important roles in the development of CIN or CC. +other 34488675 hsa-mir-139 Esophageal Squamous Cell Carcinoma We also constructed a potential UBE2C-related ceRNA network for ESCC (HCP5/has-miR5p/UBE2C). +transcription factor target 34488621 hsa-mir-100 Hypertriglyceridemia CONCLUSIONS: Our findings demonstrate a protective role of miR-100 in high fat diet induced metabolic syndrome and liver steatosis, partially mediated by the direct repression of CD36 and attenuation of hepatic lipid storage, implicating miR-100 as a possible therapeutic target in liver steatosis. +transcription factor target 34488621 hsa-mir-100 Fatty Liver CONCLUSIONS: Our findings demonstrate a protective role of miR-100 in high fat diet induced metabolic syndrome and liver steatosis, partially mediated by the direct repression of CD36 and attenuation of hepatic lipid storage, implicating miR-100 as a possible therapeutic target in liver steatosis. +lncRNA target 34488538 hsa-mir-26b Squamous Cell Carcinoma of Head and Neck Hence, targeting miR-26b-5p could be a promising therapeutic strategy for the treatment of TSCC. +lncRNA target 34488537 hsa-mir-556 Carcinoma, Non-Small-Cell Lung 5p ablation triggered pyroptotic cell death in cisplatin-treated CR-NSCLC cells via upregulating NLRP3, and the promoting effects of miR +genetics_knock down_promote 34488224 hsa-mir-483 Breast Neoplasms Finally, rescue experiments revealed that the tumor-inhibiting actions of TTC39A-AS1 knockdown on the malignant characteristics of BC cells could be reversed by inhibiting miR +lncRNA target 34487733 hsa-mir-10b Stomach Neoplasms Therefore, our results elucidate the tumor suppressor role of miR-10b-5p in gastric cancer in which it acts as a negative regulator of Tiam1 and also provide a molecular mechanism for agomir-10b-5p to treat gastric cancer. +lncRNA target 34487020 hsa-mir-525 Carcinoma, Non-Small-Cell Lung 5p in NSCLC cells, and inhibiting LINC01207 and miR +lncRNA target 34486899 hsa-mir-15a AIDS-Related Complex RESULTS: Circ_0122396 and FGF1 expression were significantly downregulated, but miR-15a-5p expression was upregulated in ARC tissues or/and H(2)O(2)-treated SRA01/04 cells in comparison with control groups. CONCLUSION: Circ_0122396 ameliorated H(2)O(2)-triggered cell injury by inducing FGF1 through sponging miR-15a-5p, providing a potential target for ARC therapy. +lncRNA target 34486705 hsa-mir-142 Liver Failure 5p inhibitors can mitigate septic liver injury by downregulating the inflammation and apoptosis via targeting SOCS1. +lncRNA target 34486677 hsa-mir-28 Keloid Finally, our data indicated that LINC00937 inhibited the ECM deposition and proliferation of keloid fibroblasts by inhibiting miR +genetics_overexpression_promote 34486645 hsa-mir-192 Thyroid Cancer, Papillary Overexpression of miR +circulation_biomarker_diagnosis_up 34486532 hsa-mir-148a Colonic Neoplasms Colon cancer stem cells (CD44+/CD133+) were selected and high/low expression of miR-148a/152 plasmids were synthesized to intervene CD44+/CD133+ colon cancer stem cells to investigate the function of miR-148a/152 in invasion, migration, proliferation, colony formation and apoptosis of cells. +circulation_biomarker_diagnosis_up 34486532 hsa-mir-152 Colonic Neoplasms Colon cancer stem cells (CD44+/CD133+) were selected and high/low expression of miR-148a/152 plasmids were synthesized to intervene CD44+/CD133+ colon cancer stem cells to investigate the function of miR-148a/152 in invasion, migration, proliferation, colony formation and apoptosis of cells. +circulation_biomarker_diagnosis_up 34486487 hsa-mir-29b Osteoporosis We compared the serum levels of XIST and miR-29b-3p among the patients with and without OP. In conclusion, XIST is highly expressed in OP, and regulates NNMT by sponging miR-29b-3p to suppress the osteogenic differentiation of BMSCs. +other 34486082 hsa-mir-155 Prostatic Neoplasms Our results corroborate that miR-155 regulates TERF1 expression in prostate cancer. +lncRNA target 34485716 hsa-mir-1 Adenocarcinoma of Lung However, the inhibitory effect of miR-31 on tumorigenesis, invasion and metastasis of lung adenocarcinoma CSCs suggested its complexity in the regulation of lung adenocarcinoma, which may be related to its extensive regulation of various target genes. +circulation_biomarker_diagnosis_up 34485531 hsa-mir-25 Nasopharyngeal Carcinoma The miR-25 inhibitor and target egg gene expression plasmids were cotransfected into HONE-1 cells for rescue experiments to investigate whether miR-25 inhibits proliferation of nasopharyngeal carcinoma cells by target genes. +lncRNA target 34485523 hsa-mir-1 Squamous Cell Carcinoma of Head and Neck 3p's low expression may facilitate tumorigenesis and evolution in HNSCC through signaling pathways. +lncRNA target 34485516 hsa-mir-143 Arthritis, Rheumatoid 3p inhibited osteoclast differentiation and decreased the levels of M-CSF and RANKL during osteoclast differentiation. +other 34485516 hsa-mir-143 Arthritis Existing studies have shown that abnormal miR3p expression was observed in both RA patients and arthritis animals, which can participate in osteoclast differentiation, and mitogen-activated protein kinase (MAPK) signaling pathway was closely related to osteoclast differentiation. +lncRNA target 34485394 hsa-mir-135b Myocardial Reperfusion Injury The results of this study elucidate a novel function of miR-135b-3p in exacerbating cardiomyocyte ferroptosis, providing a new therapeutic target for improving I/R injury. +transcription factor target 34485279 hsa-mir-7062 Carcinoma, Hepatocellular Our study found the role of miRNA5p in regulating osteoclast formation, and our findings provided a potential therapeutic target in treatment of bone metastasis of CRC. +transcription factor target 34485279 hsa-mir-7062 Colorectal Neoplasms Our study found the role of miRNA5p in regulating osteoclast formation, and our findings provided a potential therapeutic target in treatment of bone metastasis of CRC. +circRNA target 34485272 hsa-mir-143 Metabolic Syndrome CircRNF111 inhibition enhances insulin resistance and lipid deposition in MetS through regulating miR +circRNA target 34485272 hsa-mir-143 Metabolic Diseases CircRNF111 inhibition enhances insulin resistance and lipid deposition in MetS through regulating miR +genetics_knock down_suppress 34485123 hsa-mir-361 Colorectal Neoplasms 3p, which was inhibited by MIR31HG overexpression, repressed the malignant behaviors of CRC cells. +lncRNA target 34485121 hsa-mir-181b Gallbladder Neoplasms CONCLUSION: In this study, downregulation of miR-181b-5p inhibits the viability, migration, and glycolysis of GBC by upregulating PDHX under hypoxia. +other 34484820 hsa-mir-149 Wounds and Injuries However, it is unclear about the roles of miR-149 in endothelial injury. +circulation_biomarker_prognosis_ns 34484811 hsa-mir-125b Pancreatic Carcinoma In situ hybridization for miR detection in the paired resected human PDAC tissues showed that miR-125b-5p and miR-99a-5p are highly expressed in inflammatory cells in the tumor stroma, located in clusters of CD79A expressing cells of the B-lymphocyte lineage. In conclusion, we found that circulating miR-125b-5p and miR-99a-5p are potential immune-cell related prognostic biomarkers in PDAC patients after surgery. +circulation_biomarker_prognosis_ns 34484811 hsa-mir-99a Pancreatic Carcinoma In situ hybridization for miR detection in the paired resected human PDAC tissues showed that miR-125b-5p and miR-99a-5p are highly expressed in inflammatory cells in the tumor stroma, located in clusters of CD79A expressing cells of the B-lymphocyte lineage. In conclusion, we found that circulating miR-125b-5p and miR-99a-5p are potential immune-cell related prognostic biomarkers in PDAC patients after surgery. +other 34484674 hsa-mir-98 Carcinoma, Hepatocellular 5p/MAP3K2 axis was significantly associated with progressions and prognosis in HCC, NSCLC and BC patients. +other 34484674 hsa-mir-98 Breast Neoplasms 5p/MAP3K2 axis was significantly associated with progressions and prognosis in HCC, NSCLC and BC patients. +other 34484674 hsa-mir-98 Carcinoma, Non-Small-Cell Lung 5p/MAP3K2 axis was significantly associated with progressions and prognosis in HCC, NSCLC and BC patients. +genetics_overexpression_suppress 34484645 hsa-mir-21 Multiple Sclerosis BACKGROUND: Overexpression of miR-21 is a characteristic feature of patients with Multiple Sclerosis (MS) and is involved in gene regulation and the expression enhancement of pro-inflammatory factors including IFNgamma and TNF-alpha following stimulation of T-cells via the T Cell Receptor (TCR). +genetics_knock down_suppress 34484334 hsa-mir-519c Carcinoma, Hepatocellular Moreover, miR-519c-3p overexpression stimulates HCC cell growth. +other 34484332 hsa-mir-199a Colorectal Neoplasms Gambogic Acid nanoparticles may influence CC cell biological behaviors by modulating miR-199a-3p, providing a novel treatment scheme for CC in the future. +exosome 34484115 hsa-mir-93 Urinary Incontinence, Stress Our study indicates that miR-93 delivered by ADSCs-extracellular vesicles could regulate extracellular matrix remodeling of stress urinary incontinence fibroblasts and promote activation of stress urinary incontinence satellite cells through targeting F3. +transcription factor target 34483933 hsa-mir-21 Intestinal Diseases 3p could regulate the Wnt signaling pathway by targeting MTDH mRNA, suggesting the effect of miR +other 34483854 hsa-mir-24 Ischemic Stroke 3p-GPR17 may play important roles in the progression of ischemic stroke. +other 34483854 hsa-mir-93 Ischemic Stroke 3p-GPR17 may play important roles in the progression of ischemic stroke. +genetics_GWAS 34483680 hsa-mir-217 Coronary Artery Disease Conclusion These findings highlighted the important role of genetic variants of the miR-217 gene in the pathogenesis of CAD and potential targets for intervention. +lncRNA target 34483291 hsa-mir-212 Heart Failure Our findings demonstrated the novel molecular mechanism of GARS1-DT/miR5p/PI3K/AKT axis on the regulation of hypoxia-induced myocardial injury in H9C2 cells, which may provide potential therapeutic targets for acute myocardial infarction treatment. +genetics_overexpression_promote 34483150 hsa-mir-146a Diabetic Foot Overexpression of miR-146a promoted cell proliferation and migration in an in vitro DFU model and also promoted the expression of HIF-1, Wnt3a and -catenin but suppressed the expression of AKAP12. +genetics_knock down_promote 34483139 hsa-mir-24 Stomach Neoplasms Hsa_circ_0091994 knockdown inhibited the progression of GC by inhibiting the miR +other 34483137 hsa-mir-508 Ossification of Posterior Longitudinal Ligament In conclusion, our research shows that hsa_circ_0007292 regulates OPLL progression by the miR3p/SATB2 pathway. +other 34482860 hsa-mir-196a Carcinoma, Non-Small-Cell Lung Herein, by catalytic hairpin assembly as a signal amplification strategy, we designed a novel surface-enhanced Raman scattering (SERS)-lateral flow assay (LFA) strip for ultrasensitive detection of miR-21 and miR-196a-5p in non-small cell lung cancer (NSCLC) urine on a single test (T) line. The clinical feasibility of the proposed method was also evaluated by detecting the levels of miR-21 and miR-196a-5p in urine samples from NSCLC patients and healthy subjects. +other 34482860 hsa-mir-21 Carcinoma, Non-Small-Cell Lung Herein, by catalytic hairpin assembly as a signal amplification strategy, we designed a novel surface-enhanced Raman scattering (SERS)-lateral flow assay (LFA) strip for ultrasensitive detection of miR-21 and miR-196a-5p in non-small cell lung cancer (NSCLC) urine on a single test (T) line. The clinical feasibility of the proposed method was also evaluated by detecting the levels of miR-21 and miR-196a-5p in urine samples from NSCLC patients and healthy subjects. +transcription factor target 34482798 hsa-mir-155 Lipidoses In summary, downregulation of Salusin-beta protected HK-2 cells against HG-induced inflammation, oxidative stress, apoptosis and ameliorated lipid accumulation through suppressing miR +genetics_overexpression_promote 34482792 hsa-mir-195 Thyroid Neoplasms Overexpression of miR +other 34482767 hsa-mir-432 Urinary Bladder Neoplasms Conclusion: Circ-SMARCA5 high expression but miR-432 low expression is correlated with advanced tumor features and poor survival of bladder cancer patients, which present as potential prognostic markers in bladder cancer. +lncRNA target 34482528 hsa-mir-200b Leukemia, Myelogenous, Chronic, BCR-ABL Positive Foxo3 was a target of miR-200b-3p and ORLNC1 promoted BMSCs pyroptosis induced by CML through targeting miR-200b-3p/Foxo3 pathway. +genetics_knock down_promote 34482266 hsa-mir-155 Pancreatic Carcinoma 5p knockdown in PC cells enhanced anti-tumor immunity. +lncRNA target 34482026 hsa-mir-199b Prostatic Neoplasms OBJECTIVES: MicroRNA-199b-3p (miR-199b-3p) plays a crucial role in the malignant development of various cancers, but little known in prostate cancer (PCa). CONCLUSION: miR-199b-3p suppresses malignant proliferation by inhibiting PLCepsilon in prostate cancer in vitro and vivo. +epigenetics 34481973 hsa-mir-34a Osteosarcoma Mechanistically, DI-1 repressed recruitment of DNMT-1 to the promoter region of miR-34a and, in turn, decreased the methylation rate in the promoter region of miR-34a in OSA cells. +genetics_overexpression_promote 34481934 hsa-mir-769 Stomach Neoplasms 3p targeted IGF1R and IGF1R overexpression rescued the effects of miR +exosome 34481913 hsa-mir-206 Ischemia Collectively, exosomes from OGD HUVECs could protect neurons against ischemia-induced injuries, and the effects were associated with the suppression of RMRP in neurons via distance transfer of miR-206 and miR3p. +exosome 34481913 hsa-mir-1 Ischemia Collectively, exosomes from OGD HUVECs could protect neurons against ischemia-induced injuries, and the effects were associated with the suppression of RMRP in neurons via distance transfer of miR-206 and miR3p. +lncRNA target 34481903 hsa-mir-138 Pulmonary Fibrosis Collectively, we revealed that miR-138 significantly targeted ZEB2, thus inhibited the EMT process and mitigated the development of pulmonary fibrosis. +lncRNA target 34481532 hsa-mir-122 Carcinoma, Hepatocellular MicroRNA-122 (miR-122) is a liver-specific microRNA and is closely associated with HCC metastasis, which makes miR-122 a promising target for drug design and development. The results indicated that OA attenuated the migration and invasion abilities of HCC cells by upregulating miR-122 expression. +lncRNA target 34481229 hsa-mir-1764 Tuberous Sclerosis SC proliferation-inhibiting effect of metformin exposure was regulated by decreasing adenosine triphosphate level and respiratory enzyme activity in the mitochondria; this process was possibly mediated by the adenosine monophosphate-activated protein kinase (AMPK)/tuberous sclerosis complex 2 (TSC2)/mammalian target of rapamycin (mTOR) signaling pathway, which was regulated by the down-expressed miR-1764 and by the decreased antioxidant enzyme activity and excessive reactive oxygen species generation. +lncRNA target 34481218 hsa-mir-337 Breast Neoplasms 3p is a tumor-inhibitor of BC and plays its regulatory role via its downstream gene ESRP1. +transcription factor target 34480914 hsa-mir-21 Carcinoma, Non-Small-Cell Lung 5p could directly affect its silencing potency towards target genes, which finally impaired its promotion to proliferation and motility. +circRNA target 34480205 hsa-mir-513 Osteosarcoma Further mechanistic studies indicated that circCRIM1 served as a competing endogenous RNA (ceRNA) of miR-513, leading to decreases in the proliferation, migration, and invasion of OS cells. Taken together, our data uncovered a significant role of the circCRIM1/miR-513 pathway in the proliferation, migration, and invasion of OS cell lines and suggested that circCRIM1 may serve as a possible therapeutic target for OS treatment. +genetics_knock down_promote 34479589 hsa-mir-216b Colorectal Neoplasms CONCLUSION: Circ_0029803 knockdown hindered proliferation, migration, invasion, EMT, and glycolysis and promoted apoptosis in CRC cells by modulating the miR-216b-5p/SKIL axis. +other 34479583 hsa-mir-145 Colorectal Neoplasms 5p was decreased in CRC samples compared with adjacent tissues (p < 0.05). +circulation_biomarker_diagnosis_up 34479528 hsa-mir-1290 Gastrointestinal Neoplasms CONCLUSIONS: Our findings indicate that circulating miR-1290 is a potential biomarker for gastrointestinal cancer diagnosis and monitoring. +genetics_knock down_promote 34479497 hsa-mir-1290 Glioma In addition, RORA was a target of miR-1290, and glioma cell malignant phenotypes promoted by miR-1290 restoration were partly blocked by RORA overexpression. +transcription factor target 34479475 hsa-mir-153 Hearing Loss, Sensorineural As miR-153 can target and regulate KCNQ4, we sought to study the role of miR-153 in SNHL. This study demonstrates that miR-153 inhibition significantly restores KNCQ4 in cochlea after noise exposure, which attenuates SNHL. +other 34479063 hsa-mir-4535 Pregnancy Complications, Infectious 5p levels in amniotic fluid may be considered clinically predictive for foetal morbidity of infection. +other 34479063 hsa-mir-1915 Pregnancy Complications, Infectious 5p levels in amniotic fluid may be considered clinically predictive for foetal morbidity of infection. +other 34479022 hsa-mir-126 Myocardial Ischemia CONCLUSION: In summary, YQHX improves angiogenesis by regulating the miR-126/PI3K/Akt signaling pathway, which indicates that YQHX could be a promising therapeutic strategy for ischemic myocardium. +other 34478872 hsa-mir-17 Carcinoma, Hepatocellular miR5p upregulation was associated with MPM downregulation in HCC tissues. +genetics_overexpression_promote 34478121 hsa-mir-643 Endometritis CircFADS2 is downregulated in endometritis, and it overexpression promotes miR-643 maturation in HEnEpCs to suppress cell apoptosis. +lncRNA target 34478013 hsa-mir-107 Glioma CONCLUSION: Our data suggested that LINC00152 is a candidate prognostic marker of glioma, and that the LINC00152/MIR-107/RAB10 axis plays a pivotal role in regulation of the glioma malignancy, and therefore, targeting the axis might be an effective therapeutic strategy to treat glioma. +exosome 34478012 hsa-mir-490 Sepsis Taken together, our results suggest that exosomes derived from ADSCs attenuate sepsis-induced lung injury by delivery of circ-Fryl and regulation of the miR3p/SIRT3 pathway. +other 34478010 hsa-mir-1 Aortic Aneurysm, Thoracic Moreover, miR3p was decreased, and ADAM10 was upregulated in TAA aorta tissues and VSMC. +genetics_overexpression_promote 34477918 hsa-mir-193a Osteoporosis Our results showed that miR-193a was overexpressed, while SIRT7 was downregulated in osteoporosis. +other 34477698 hsa-mir-181a Ischemic Stroke MicroRNA-181a (miR-181a) is one of the upregulated miRNAs in the ischemic brain and its downregulation can reduce the damage to the ischemic brain. +lncRNA target 34477483 hsa-mir-3690 Colorectal Neoplasms The present results demonstrated that SNHG10 promotes colorectal cancer cells the malignant progression by targeting miR-3690.Abbreviations: CRC: Colorectal cancer; Lnc RNA: Long noncoding RNA; microRNAs: miRNAs/miRs; RT-qPCR: reverse transcription quantitative polymerase chain reaction; CCK-8: Cell Counting Kit-8. +lncRNA target 34477476 hsa-mir-20b Colorectal Neoplasms In CRC cells, miR-20b-5p was sponged by COL4A2-AS1 and hypoxia-inducible factor 1 alpha subunit (HIF1A). The current findings showed that COL4A2-AS1 promoted the proliferation, and aerobic glycolysis of CRC cells potentially through modulating the miR-20b-5p/HIF1A axis. +lncRNA target 34477472 hsa-mir-181a Purpura CONCLUSIONS: The lncRNA MEG8 sponged miR-181a-5p, which contributes to M1 macrophage polarization by regulating SHP2 expression in HSP rats.Key MessagesLncRNA MEG8 downregulation and M2 polarization in Henoch Schonlein purpura rats.MEG8 upregulation enhances M1 polarization and suppresses JAK2/STAT3 pathway.MEG8 sponges miRNA-181a-5p to regulate SHP2 expression.MiRNA-181a-5p upregulation reverses lncRNA MEG8-mediated enhancement of M1 polarization and inhibition of JAK2/STAT3 pathway.SHP2 downregulation reverses lncRNA MEG8-mediated enhancement of M1 polarization and inhibition of JAK2/STAT3 pathway. +other 34477137 hsa-mir-503 lung squamous cell carcinoma AS1, hsa-mir-96, PROK2 ceRNA axes were found to be important for the immune function, pathogenesis, and prognosis of SqCLC. +other 34477137 hsa-mir-96 lung squamous cell carcinoma AS1, hsa-mir-96, PROK2 ceRNA axes were found to be important for the immune function, pathogenesis, and prognosis of SqCLC. +genetics_knock down_promote 34477002 hsa-mir-2682 Carcinoma, Non-Small-Cell Lung HDAC1 overexpression abolished the effects of miR +other 34476933 hsa-mir-183 psoriasis 1 KCNQ1OT1 promotes the proliferation and migration of psoriatic keratinocytes by regulating miR3p/GAB1. +lncRNA target 34476924 hsa-mir-216a Bronchopneumonia miR-216a-5p may be a valuable target for anti-inflammation treatment in bronchopneumonia. +lncRNA target 34476924 hsa-mir-216a Respiratory Tract Infections miR-216a-5p may be a valuable target for anti-inflammation treatment in bronchopneumonia.Bronchopneumonia is a common respiratory infection disease and is the main cause of hospitalization in children under 5 years of age. +exosome 34476508 hsa-mir-29a Cicatrix In summary, the current data indicated that miR29amodified hADSC exosome therapy can decrease scar formation by inhibiting the TGF2/Smad3 signaling pathway via its derived exogenous miR29a, and this may be useful for the future treatment of pathological scars by providing a potential molecular basis. +other 34476503 hsa-mir-502 Tuberculosis The Gene Expression Omnibus database was used to analyze miR5023p expression in patients with TB and healthy individuals. +genetics_overexpression_suppress 34476503 hsa-mir-502 Light Fixation Seizure Syndrome ROCK1 overexpression reversed the miR5023p inhibitory effect on cytokine production in M. +lncRNA target 34476497 hsa-mir-448 Colorectal Neoplasms The findings of the present study indicated that lncRNA NEAT1 modulates IRinduced pyroptosis and viability in HCT116 cells via miR448 by regulating the expression, but not activation of GSDME. +genetics_knock down_promote 34476495 hsa-mir-93 Leukemia, Myeloid, Acute The knockdown of miR93 in HL60 cells inhibited AML cell proliferation and resistance to apoptosis, while the overexpression of miR93 in THP1 cells led to contrasting results. +other 34476267 hsa-mir-200c COVID-19 Our results suggest that miR-200c-3p is a predictor of severity independent of COVID-19 risk factors, which could represent a way of screening patients affected by SARS-CoV-2. +other 34476004 hsa-mir-193a Osteosarcoma The miR-193a-5p/NCX2/AKT axis promotes invasion and metastasis of osteosarcoma. +genetics_overexpression_promote 34476001 hsa-mir-637 Thyroid Neoplasms PANDAR negatively correlated with miR-637, and miR-637 overexpression suppressed thyroid gland carcinoma progression, which could be reversed by PANDAR. +lncRNA target 34475987 hsa-mir-1207 Glioma 3p/HNF1B signaling axis may serve as novel molecular targets for glioma prevention and treatment. +lncRNA target 34475985 hsa-mir-29b Carcinoma, Ovarian Epithelial Conclusions: The lncRNA-H19/miR-29b-3p axis improved carboplatin resistance of EOC by targeting STAT3, indicating a possible approach to improving chemotherapy for EOC. +genetics_knock down_suppress 34475974 hsa-mir-361 Uterine Cervical Neoplasms Knockdown of LINC01123 inhibits cell viability, migration and invasion via miR-361-3p/TSPAN1 targeting in cervical cancer. +target gene 34475958 hsa-mir-370 Breast Neoplasms miR-370-3p as a Novel Biomarker Promotes Breast Cancer Progression by Targeting FBLN5. +other 34475786 hsa-mir-223 Polycystic Ovary Syndrome 3p and NF-kappaB levels in aggravating PCOS pancreatic autophagy and consequent impairments. +transcription factor target 34475393 hsa-mir-181a Osteoporosis Altogether, this study demonstrated for the first time the role of miRNA-181a/DUSP6 in the progression of osteoporosis via the ERK2 and SMAD2 signaling pathway. +transcription factor target 34474856 hsa-mir-34a Breast Neoplasms Folate targeted hybrid lipo-polymeric nanoplexes containing docetaxel and miRNA-34a for breast cancer treatment. +circulation_biomarker_diagnosis_ns 34474768 hsa-mir-208b Atrial Fibrillation We calculated serum levels of miR-208 b in paroxysmal and persistent AFib, embolic cerebrovascular accident patients with AFib as possible etiology and controls. There was a statistically significant change of miR-208 b levels in paroxysmal (p = 0.044) and persistent (p = 0.040) AFib patients, but not for embolic CVA patients. +circulation_biomarker_diagnosis_ns 34474460 hsa-mir-21 Glioblastoma The antagomir-21/RAP nanoparticles were administrated intranasally in the intracranial glioblastoma animal models to bypass the blood-brain-barrier. +other 34474410 hsa-mir-107 Acute Coronary Syndrome CONCLUSION: Platelet miR-107 participated in clopidogrel resistance in ACS/PCI patients by regulating P2Y12 expression. +genetics_knock down_suppress 34474408 hsa-mir-455 Brain Ischemia CONCLUSION: Circ_0000491 knockdown inhibited HG-induced apoptosis, inflammation, oxidative stress, and fibrosis in SV40-MES13 cells by regulating miR3p/Hmgb1 axis. +genetics_knock down_suppress 34474408 hsa-mir-455 Pulmonary Fibrosis CONCLUSION: Circ_0000491 knockdown inhibited HG-induced apoptosis, inflammation, oxidative stress, and fibrosis in SV40-MES13 cells by regulating miR3p/Hmgb1 axis. +genetics_knock down_suppress 34474408 hsa-mir-455 Inflammation CONCLUSION: Circ_0000491 knockdown inhibited HG-induced apoptosis, inflammation, oxidative stress, and fibrosis in SV40-MES13 cells by regulating miR3p/Hmgb1 axis. +lncRNA target 34474269 hsa-mir-750-1 Charcot-Marie-Tooth disease type 3 viridis might respond to DSP toxins through miR-750_1, novel_mir4 and miR-71_5 regulating the expression of relevant target genes involved in apoptosis, cytoskeleton, and immune response, etc. +lncRNA target 34474269 hsa-mir-71 Charcot-Marie-Tooth disease type 3 viridis might respond to DSP toxins through miR-750_1, novel_mir4 and miR-71_5 regulating the expression of relevant target genes involved in apoptosis, cytoskeleton, and immune response, etc. +genetics_knock down_promote 34474146 hsa-mir-223 Lymphoma, Mantle-Cell 3p knockdown promoted proliferation and inhibited apoptosis of MCL cells after ibrutinib treatment in vitro and vivo, whereas CHUK knockdown reversed downregulated miRNA +lncRNA target 34473845 hsa-mir-21 Rhinitis, Allergic CONCLUSION: Lnc-GAS5 is negatively correlated with that of its targets (miR-21 and miR-140) in AR; meanwhile, lnc-GAS5, miR-21, and miR-140 are correlated with disease risk, symptom severity, and Th1/Th2 imbalance in AR, suggesting the potential of these biomarkers in the development and progression of AR. +lncRNA target 34473845 hsa-mir-140 Rhinitis, Allergic CONCLUSION: Lnc-GAS5 is negatively correlated with that of its targets (miR-21 and miR-140) in AR; meanwhile, lnc-GAS5, miR-21, and miR-140 are correlated with disease risk, symptom severity, and Th1/Th2 imbalance in AR, suggesting the potential of these biomarkers in the development and progression of AR. +circulation_biomarker_diagnosis_ns 34472584 hsa-mir-494 Muscular Dystrophy, Duchenne Cellular and circulating levels of miR3p had shown significant increase in symptomatic carriers, which may indicate significant roles played by this miRNA in the onset of muscular weakness. +lncRNA target 34472490 hsa-mir-615 Parkinson Disease These findings suggest that inhibition of HOTTIP mitigates neuronal apoptosis and microglial activation in PD models by modulating miR3p/FOXO1. +genetics_knock down_suppress 34472482 hsa-mir-181c Reperfusion Injury, Cerebral Ischemia These findings suggest that MEG3 knockdown inhibited autophagy and alleviated cerebral ischemia/reperfusion injury through the miR-181c-5p/ATG7 signaling pathway. +circulation_biomarker_diagnosis_ns 34472480 hsa-mir-185 Brain Injuries, Traumatic These findings suggest that circLphn3, as a molecular sponge of miR5p, regulates tight junction proteins' expression after traumatic brain injury, and it thereby improves the permeability of the blood-brain barrier. +lncRNA target 34472153 hsa-mir-378 Laryngeal Neoplasms Interestingly, we discovered that LINC00888 functioned as an miRNA sponge to suppress the effect of miR-378g on laryngeal cancer cells behaviors, as well as positively regulate TFRC expression. +transcription factor target 34472106 hsa-mir-129 Prostatic Neoplasms 5p hindered the biological functions of cancer cells via inhibiting DLX1 expression. +other 34472046 hsa-mir-145 Glomerulonephritis, Membranous 5p-PRKG1, may be associated with MN development. +other 34472046 hsa-mir-148a Glomerulonephritis, Membranous 5p-PRKG1, may be associated with MN development. +lncRNA target 34471998 hsa-mir-570 Colonic Neoplasms The results proved that miR-570 could potentially function as a tumor suppressor and a potential prognostic factor in patients with colon cancer. +circRNA target 34471941 hsa-mir-195 Glioma 5p/TGIF2 axis, suggesting a promising circRNA-targeted therapy for glioma treatment. +other 34471485 hsa-mir-34a Hirschsprung Disease Further rescue experiments have confirmed that DRAIC regulates cell proliferation and migration by affecting the miR-34a-5p/ITGA6 signal axis in HSCR. CONCLUSION: DRAIC promoted cell proliferation and migration by regulating the miR-34a-5p/ITGA6 signal axis in HSCR. +lncRNA target 34471374 hsa-mir-410 Neonatal Sepsis 3p was a target of NORAD and lowly expressed in the NS patients. +circulation_biomarker_diagnosis_up 34470640 hsa-mir-216b Carcinoma, Non-Small-Cell Lung Pearson correlation analysis showed a negative correlation between SUVmax and miRNA-216b (plasma and tissue) in patients with four types of NSCLC. +lncRNA target 34470587 hsa-mir-223 Glioblastoma Eventually, rescue assays validated PITPNA-AS1 sponged miR3p to promote EGFR expression, thus activating PI3K/AKT signaling pathway to accelerate proliferation and inhibit apoptosis of GBM cells. +genetics_knock down_promote 34470585 hsa-mir-195 Carcinoma, Non-Small-Cell Lung Besides, circ_0060937 depletion suppressed tumor growth in vivo.Circ_0060937 knockdown hindered NSCLC development and glycolysis via regulating miR +lncRNA target 34470582 hsa-mir-192 Glioblastoma 5p and RAB2A in GBM cells was explored through pull down, luciferase reporter, and RIP assays. +lncRNA target 34470574 hsa-mir-211 Colorectal Neoplasms Mechanistically, HOTAIR facilitated the expression of the microRNA (miR)5p target gene fms-like tyrosine kinase-1 (FLT-1), thereby modulating cancer stem cell (CSC) properties in CRC. +lncRNA target 34470571 hsa-mir-212 Fetal Growth Retardation 3p could target PGF, and the expression of both was negatively correlated in FGR group tissues. +lncRNA target 34469714 hsa-mir-124 osteogenesis imperfecta type 1 In vivo, intravitreal injection of miR3p, shMALAT1 decreased EGR1 expression and markedly suppressed retinal neovascularization in OIR models. +other 34469714 hsa-mir-124 Retinopathy of Prematurity 3p/EGR1 regulatory axis is partly responsible for retinal neovascularization, which may provide a novel theoretical basis for the pathogenesis of ROP. +transcription factor target 34469060 hsa-mir-34a Carcinoma, Non-Small-Cell Lung Mechanistic analyses indicated that As(4) S(4) might sensitize NSCLC cells to DDP through targeting p53/miR-34a-5p/PD-L1 axis. +exosome 34469038 hsa-mir-106a Nasopharyngeal Carcinoma Taken together, these findings indicate that exosomal miR-106a-5p could be a promising diagnostic biomarker and drug target for patients with NPC. +genetics_knock down_suppress 34469009 hsa-mir-515 Prostatic Neoplasms 5p silencing largely diminished circ-PAPPA knockdown-mediated effects in PCa cells. +lncRNA target 34468912 hsa-mir-944 Colorectal Neoplasms Intriguingly, it was suggested that NP1 tackled the CRC cells through down-regulation of the H19, HOTTIP, HULC, LINC00641, miR-200, miR-92a, miR-21, YKL-40, PPARgamma, and VEGF expressions, as well as up-regulation of the miR-944 and ECN expressions. +lncRNA target 34468912 hsa-mir-21 Colorectal Neoplasms Intriguingly, it was suggested that NP1 tackled the CRC cells through down-regulation of the H19, HOTTIP, HULC, LINC00641, miR-200, miR-92a, miR-21, YKL-40, PPARgamma, and VEGF expressions, as well as up-regulation of the miR-944 and ECN expressions. +other 34468254 hsa-mir-145 Cardiomegaly circNfix attenuated pressure overload-induced cardiac hypertrophy by regulating the miR5p/ATF3 axis. +lncRNA target 34468207 hsa-mir-574 Pancreatic Carcinoma 3p/PIM3 axis might contribute to novel biomarker development in PC treatment.NEW & NOTEWORTHY RGMB-AS1 promotes PC cell proliferation, elevates PC cell migration capacity, inhibits PC cell apoptosis, and promotes PC cell proliferation and migration but inhibits cell apoptosis via targeting miR +lncRNA target 34468015 hsa-mir-32 pancreatic adenocarcinoma miR325p significantly inhibited the proliferation of PAAD cells and markedly reduced migration and invasion compared with the negative controls. +circulation_biomarker_diagnosis_ns 34468014 hsa-mir-34a Hypertension, Pulmonary NEAT1 was not only highly expressed in the serum of PAH patients but its silencing also alleviated PAH by regulating miR34a5p/KLF4 in vitro. +transcription factor target 34468010 hsa-mir-498 Uterine Cervical Neoplasms MIR93HG promoted the proliferation cervical cancer cells via EP300 and miR498. These in vitro and in vivo findings demonstrate the regulatory role of the MIR93HG/miR498/EP300 axis in cervical cancer cell growth. +lncRNA target 34467896 hsa-mir-34a Carcinoma, Non-Small-Cell Lung In vitro assays demonstrated that both miR-34a and miR-34b/c inhibits SCC cells proliferation, migration and invasion via Notch1 pathway, while miR-34b/c effects more than miR-34a does. +lncRNA target 34467896 hsa-mir-34 Carcinoma, Non-Small-Cell Lung In vitro assays demonstrated that both miR-34a and miR-34b/c inhibits SCC cells proliferation, migration and invasion via Notch1 pathway, while miR-34b/c effects more than miR-34a does. +lncRNA target 34466494 hsa-mir-200a Stomach Neoplasms CONCLUSION: Our findings suggest that the miR-28 and miR-200a have tumor-suppressor functions and may be considered as potential biomarkers for gastric cancer diagnosis and prognosis. +lncRNA target 34466494 hsa-mir-28 Stomach Neoplasms CONCLUSION: Our findings suggest that the miR-28 and miR-200a have tumor-suppressor functions and may be considered as potential biomarkers for gastric cancer diagnosis and prognosis. +other 34466154 hsa-mir-1 Colonic Neoplasms AuNPs can increase the capacity of miR-31 quantification, representing a new strategy to develop non-invasive tools for the molecular diagnosis and monitoring of colon cancer +other 34466069 hsa-mir-144 Glomerulonephritis, IGA Network construction ultimately lead to the identification of nine gene named FN1, EGR1, FOS, JUN, SERPINE1, MMP2, ATF3, MYC, and IL1B and one novel key miRNA namely, has-miR3p as biomarker for diagnosis and therapy of IgAN. +target gene 34465995 hsa-mir-101 Ischemic Stroke MiR-101 Protects Against the Cerebral I/R Injury Through Regulating JAK2/STAT3 Signaling Pathway. +transcription factor target 34465878 hsa-mir-2137 Hypoxia-Ischemia, Brain Mir-2137, -335, -137, and -376c were significantly altered by neonatal HIBI at 24 and 72h, with 3 of the 4 demonstrating multiphasic expression (different direction of differential expression at 24 versus 72h). Mir-2137, -335, -137, and -376c were significantly altered by neonatal HIBI and therefore deserve further investigation as possible therapeutic targets. +circulation_biomarker_diagnosis_up 34465793 hsa-mir-19a Breast Neoplasms Both exosomal miR-19a and Integrin-Binding Sialoprotein (IBSP) are found to be significantly upregulated and secreted from bone-tropic ER(+) breast cancer cells, increasing their levels in the circulation of patients. +other 34465369 hsa-mir-124 Retinitis This shift was further demonstrated by a change in the seed binding regions of miR3p, the most abundant retinal AGO2-bound miRNA, and has known roles in regulating retinal inflammation. +genetics_overexpression_promote 34465330 hsa-mir-182 Nasopharyngeal Carcinoma Furthermore, overexpression of miR +lncRNA target 34465322 hsa-mir-34a Pulmonary Arterial Hypertension Inhibition of HDAC1 alleviates pulmonary arterial remodeling and PAH through up-regulation of miR-34a level and subsequent reduction of MMP-9/TIMP-1 and MMP-2/TIMP-2, suggesting that inhibition of HDAC1 might have potential value in the management of PAH. +other 34465058 hsa-let-7 Fetal Growth Retardation In conclusion, PCE can cause female adrenal dysfunction with matrilineal multi-generation inheritance, which is related to the programming alteration of the H19/let-7 axis. +lncRNA target 34464885 hsa-mir-532 Neurologic Manifestations 5p in IS via targeting BACH1. +lncRNA target 34464885 hsa-mir-532 Ischemic Stroke 5p in IS via targeting BACH1. +other 34464683 hsa-mir-181a Diabetes Mellitus, Type 2 CONCLUSIONS: Our observations suggest that MSC-derived miR-181a-5p mitigates glucagon secretion of alpha-cells by regulating PTEN/AKT signaling, which provides novel evidence demonstrating the potential for MSCs in treating T2DM. +other 34464666 hsa-mir-145 Atherosclerosis 5p. +transcription factor target 34464226 hsa-mir-21 Pre-Eclampsia Using RT-qPCR, western blot, and immunohistochemistry, it was demonstrated that miR-21 expressions were significantly decreased in preeclampsia while RASA1 were increased. miR-21 may serve key roles in the development of preeclampsia by targeting RASA1. +other 34463892 hsa-mir-98 Stomach Neoplasms The network directly related to PGC was as follows: SNHG16/hsa_circ_0008197-hsa-mir5p/hsa-let-7f-5 qRT-PCR validation results showed that PGC, PPARG, SNHG16, and hsa_circ_0008197 were differentially expressed in gastric cancer cells and tissues: PGC positively correlated with PPARG (r=0.276, P=0.009), SNHG16 (r=0.35, P=0.002), and hsa_circ_0008197 (r=0.346, P=0.005). +other 34463887 hsa-mir-146a Colorectal Neoplasms METHODS: In this study, 50 pairs of tumor and tumor margin samples of CRC patients were investigated to assess the expression levels of miR-196, miR-132, miR-146a, and miR-134 in this cancer. +other 34463887 hsa-mir-134 Colorectal Neoplasms METHODS: In this study, 50 pairs of tumor and tumor margin samples of CRC patients were investigated to assess the expression levels of miR-196, miR-132, miR-146a, and miR-134 in this cancer. +other 34463887 hsa-mir-196 Colorectal Neoplasms METHODS: In this study, 50 pairs of tumor and tumor margin samples of CRC patients were investigated to assess the expression levels of miR-196, miR-132, miR-146a, and miR-134 in this cancer. +other 34463887 hsa-mir-132 Colorectal Neoplasms METHODS: In this study, 50 pairs of tumor and tumor margin samples of CRC patients were investigated to assess the expression levels of miR-196, miR-132, miR-146a, and miR-134 in this cancer. +lncRNA target 34463266 hsa-mir-145 Acquired Immunodeficiency Syndrome CRISPR-based editing of the miRNA target site preserves CFTR mRNA and function in airway epithelial cells INTERPRETATION: Given the important roles of TGF-beta signaling and the multitude of genes regulated by miRNAs, we demonstrate that CRISPR-based gene-specific microRNA antagonism approach can preserve CFTR mRNA and function in the context of HIV Tat and TGF-beta signaling without suppressing expression of other genes regulated by miR +lncRNA target 34463266 hsa-mir-145 Cystic Fibrosis TGF-beta signaling, upregulated by HIV Tat, and in chronic airway diseases and smokers upregulates miR5p to suppress cystic fibrosis transmembrane conductance regulator (CFTR). +other 34463266 hsa-mir-509 Acquired Immunodeficiency Syndrome 3p. +lncRNA target 34463266 hsa-mir-145 Pulmonary Disease, Chronic Obstructive TGF-beta signaling, upregulated by HIV Tat, and in chronic airway diseases and smokers upregulates miR5p to suppress cystic fibrosis transmembrane conductance regulator (CFTR). +lncRNA target 34463227 hsa-mir-290 Bone Diseases CONCLUSION: Our findings indicate that the PTH-responsive miR-290 regulated Runx2- mediated MMP-13 expression in rat osteoblastic cells, suggesting miR-290 as a molecular marker or target in bone and bone-related diseases. +lncRNA target 34463208 hsa-mir-1301 Squamous Cell Carcinoma of Head and Neck Overall, LINC01207 promotes OSCC progression via the miR3p/LDHA axis. +genetics_overexpression_promote 34463194 hsa-mir-451 Glioma In this study, we transfected lentivirus expressing miRNA-451 to test the effect of miRNA-451 overexpression on malignant glioma cell lines and confirmed that IKKbeta is a target gene of miRNA-451 by luciferase assay. +other 34463189 hsa-mir-126 Diabetes Mellitus High glucose environment of diabetes can affect the adhesion of EPCs by decreasing the expression of CXC chemokine receptor 4 (CXCR4) and affect the proliferation of EPCs by decreasing the expression of miR-126. +lncRNA target 34463129 hsa-mir-183 Osteoarthritis mediated inhibition of macrophage infiltration, and dual luciferase reporter assay demonstrated that miR-183 directly targeted TGFalpha. +other 34463003 hsa-mir-135 Breast Neoplasms Our data suggest that EIF4A3-induced hsa_circ_0088088 stimulates the carcinogenic effects of breast tumors by sponging miR5p. +other 34462890 hsa-mir-191 Out-of-Hospital Cardiac Arrest 5p was down-regulated in patients with poor neurological outcomes, and it could be used as a promising novel biomarker for prediction of neurological outcome and survival after OHCA. +circRNA target 34462874 hsa-mir-424 Pre-Eclampsia 5p/NFAT5 axis, providing an underlying circRNA-targeted therapy for preeclampsia. +circRNA target 34462830 hsa-mir-135b Arthritis, Rheumatoid Circ_0008360 inhibited the proliferation, migration, and inflammation and facilitated apoptosis of RA-FLSs by sponging miR-135b-5p and upregulating HDAC4, providing a potential target for prevention and treatment of RA. +other 34462662 hsa-mir-21 Sepsis Altered expression levels of miR-126 and miR-21 reflected the severity of inflammatory response and indicated levels of T lymphocyte apoptosis in septic rats. +other 34462662 hsa-mir-126 Sepsis Altered expression levels of miR-126 and miR-21 reflected the severity of inflammatory response and indicated levels of T lymphocyte apoptosis in septic rats. +genetics_knock down_suppress 34461926 hsa-mir-876 Stomach Neoplasms CONCLUSION: Circ-RNF111 knockdown relieved the development of GC by regulating miR +other 34461731 hsa-mir-133a Myocardial Infarction Here, we developed an electrochemiluminescence biosensor based on an entropy-driven strand displacement reaction (ETSD) and a tetrahedral DNA nanostructure (TDN) for the detection of the potential AMI biomarker microRNA-133a. +genetics_overexpression_promote 34461605 hsa-mir-23b Pancreatic Carcinoma Functional analysis showed that the overexpression of miR-23b-3p inhibited the expression of HMGB2 in PC cells and affected cell proliferation, invasion and apoptosis. +genetics_knock down_suppress 34461493 hsa-mir-19b Fibrosis, Renal DISCUSSION: These results provided evidence that knockdown of XIST inhibited apoptosis and inflammation of renal fibrosis via miR-19b-mediated downregulation of SOX6. +transcription factor target 34461437 hsa-mir-1207 Prostatic Neoplasms 5p inhibited the expression of PYCR1 to repress the progression of prostate cancer by inhibiting cell growth and elevating cell apoptosis. +other 34461327 hsa-mir-27a Concussion, Sports-Related A single ratio (miR-27a-5p/miR-30a-3p) displayed the highest accuracy (AUC=0.810, sensitivity=82.4%, specificity=73.3%) for differentiating concussed and non-concussed participants. +lncRNA target 34460893 hsa-mir-181b Community-Acquired Pneumonia This study aims to evaluate the clinical significance of miR-181b in SCAP, which has been revealed to be dysregulated in acute respiratory distress syndrome events due to SCAP. +genetics_knock down_promote 34460438 hsa-mir-149 Squamous Cell Carcinoma of Head and Neck Knockdown of lncRNA GACAT1 and transfection with miR-149 inhibitor reversed the effect of GACAT1 silencing on OSCC cells. +lncRNA target 34460057 hsa-mir-493 Glioma 5p has been identified as a tumor inhibitor to suppress the progressions of several tumors while its role in gliomas remains unknown. +genetics_knock down_promote 34460046 hsa-mir-1200 Glioma Besides that, rescue assay suggested that circ_0000215 attenuated the inhibitory effects of sevoflurane on glioma cell growth and metastasis, which were reversed by miR-1200 overexpression or NCR3LG1 knockdown. +lncRNA target 34459789 hsa-mir-384 Glioma CONCLUSION: LINC01087 is highly expressed in glioma and can participate in the growth of glioma through miR-384/Bcl-2 axis. +exosome 34459668 hsa-mir-146a Wounds and Injuries Objective: To investigate the effect of MicroRNA-146a modified adipose-derived stem cell exosomes on the proliferation and migration of fibroblasts and the therapeutic effect on wound healing. Conclusions: MicroRNA-146a modified adipose stem cell exosomes could regulate the expression of SERPINH1 and p-ERK, promote the migration and proliferation of fibroblasts, and neovascularization to promote the wound healing of rat back. +genetics_knock down_promote 34459457 hsa-mir-1179 Stomach Neoplasms MiR-1179 was a direct target of circ_0000592, and circ_0000592 silencing-mediated effects in GC cells were partly reversed by the knockdown of miR-1179. +exosome 34459455 hsa-mir-577 Colorectal Neoplasms Circ_0007334 and KLF12 were increased, and miR-577 was decreased in CRC tissues and cells. These results presented that circ_0007334 deficiency exerts a tumor-suppressor by the miR-577/KLF12 axis in CRC, and indicated that exosomal circ_0007334 could hinder CRC tumor growth and angiogenesis in vivo. +lncRNA target 34459454 hsa-mir-194 psoriasis 1 PF controls the proliferation and migration of psoriatic HaCat cells via the NEAT1/miR +genetics_overexpression_suppress 34459452 hsa-mir-143 Leukemia 3p repressed viability and proliferation of AML cells and overexpression of KAT6A partially reversed the inhibitory effects of miR +genetics_knock down_suppress 34459233 hsa-mir-96 Cardiomyopathies This study investigated the functional mechanism of exosomal microRNA-96 (miR-96) derived from bone marrow mesenchymal stem cells (BMSCs) in myocardial toxicity induced by doxorubicin. Rac1 inhibition could downregulate the expression of the nuclear factor-kappaB signaling and further reverse the promotion of miR-96 knockdown on doxorubicin-induced myocardial toxicity. +genetics_overexpression_promote 34459207 hsa-mir-455 Carcinoma, Hepatocellular PPM1F overexpression offsets the inhibitory effect of miR +exosome 34459124 hsa-mir-205 Prostatic Neoplasms NEAT1 shuttled by PCa-derived exosomes could be transferred into hBMSCs, where NEAT1 exerted inductive properties in osteogenic differentiation of hBMSCs through the upregulation of RUNX2 by competitively binding to miR +circulation_biomarker_diagnosis_ns 34459123 hsa-mir-485 Fibrosis, Atrial CONCLUSIONS: In conclusion, serum-derived EV containing MIAT facilitates atrial remodeling and exacerbates the AF by abolishing the miR5p-mediated CXCL10 inhibition. +circulation_biomarker_diagnosis_ns 34459123 hsa-mir-485 Inflammation CONCLUSIONS: In conclusion, serum-derived EV containing MIAT facilitates atrial remodeling and exacerbates the AF by abolishing the miR5p-mediated CXCL10 inhibition. +circulation_biomarker_diagnosis_ns 34459123 hsa-mir-485 Atrial Fibrillation CONCLUSIONS: In conclusion, serum-derived EV containing MIAT facilitates atrial remodeling and exacerbates the AF by abolishing the miR5p-mediated CXCL10 inhibition. +transcription factor target 34459097 hsa-mir-497 Parkinson Disease In conclusion, silencing of miR5p alleviates PD by suppressing cell apoptosis and promoting autophagy in a FGF2 dependent manner, which will provide a novel target for Parkinson's disease management. +other 34458512 hsa-mir-9 Chanarin-Dorfman Syndrome In both CMS animals and primary neurons, decreased miR5p levels were associated with dendritic simplification, while treatment with ketamine completely rescued the changes. +other 34458512 hsa-mir-9 congenital myasthenic syndrome 6 5p changes, REST protein expression levels were remarkably increased in both CMS vulnerable animals and corticosterone-treated neurons, while ketamine completely abolished this alteration. +other 34458512 hsa-mir-9 Anhedonia 5p expression inversely correlated with the anhedonic phenotype. +lncRNA target 34458374 hsa-mir-1 Stroke Compared with the model group, the neurological impairment score, cerebral infarct size, and volume were significantly increased in the miR-1 mimic group and significantly decreased in the miR-1 inhibitor group (p < 0.05). +target gene 34458282 hsa-mir-216 Colorectal Neoplasms Isoflurane Suppresses Proliferation, Migration, and Invasion and Facilitates Apoptosis in Colorectal Cancer Cells Through Targeting miR-216. +other 34458143 hsa-mir-96 Colorectal Neoplasms miRNA-96-5p expression is an important factor affecting the radiation response of colorectal cancer cells. +lncRNA target 34458001 hsa-mir-132 Liver Cirrhosis Therapeutic inhibition of miR-132 might be a new approach to alleviate liver fibrosis, and treatment efficacy can be monitored by observing EV shedding. +epigenetics 34457998 hsa-mir-5088 Breast Neoplasms 5p was upregulated by hypomethylation of its promoter, promoted by Fyn, and was involved in malignancy in breast cancer. +other 34457199 hsa-mir-16 Colorectal Neoplasms The miR-15b, miR-16, and miR-21 panel was used to discriminate the colorectal adenoma group and CRC group with a sensitivity and specificity of 85.19% and 82.09%, respectively. +circulation_biomarker_diagnosis_up 34457199 hsa-mir-15b Colorectal Neoplasms AIM: To evaluate the diagnostic value of CRC by detecting four exosomal microRNAs (miRNAs) (miR-15b, miR-16, miR-21, and miR-31) that were demonstrated to have potential diagnostic value in serum. +circulation_biomarker_diagnosis_up 34457199 hsa-mir-21 Colorectal Neoplasms AIM: To evaluate the diagnostic value of CRC by detecting four exosomal microRNAs (miRNAs) (miR-15b, miR-16, miR-21, and miR-31) that were demonstrated to have potential diagnostic value in serum. +other 34457197 hsa-mir-1269a Esophageal Squamous Cell Carcinoma CONCLUSION: miR-1269a can be used as a potential indicator for the prognosis of ESCA patients. +lncRNA target 34457116 hsa-mir-206 Breast Neoplasms The LINC00276&MALAT1/miR-206/FZD4-Wnt7b pathway was also identified which may be useful in future research on targets against breast cancer metastasis and recurrence. +lncRNA target 34457116 hsa-mir-206 Stroke The LINC00276&MALAT1/miR-206/FZD4-Wnt7b pathway was also identified which may be useful in future research on targets against breast cancer metastasis and recurrence. +other 34457087 hsa-mir-136 Squamous Cell Carcinoma of Head and Neck CONCLUSION: Collectively, PSMA3-AS1 as a risk factor facilitated malignant behaviors of OSCC cells, related to the miR5p/FN1 axis. +therapeutic target 34457064 hsa-mir-212 Lymphoma miR-212-3p may serve as a novel therapeutic target and marker for lymphoma. +target gene 34457004 hsa-mir-651 Carcinoma, Hepatocellular miR-651-3p Enhances the Sensitivity of Hepatocellular Carcinoma to Cisplatin via Targeting ATG3-Mediated Cell Autophagy. +genetics_overexpression_promote 34456631 hsa-mir-34b Osteosarcoma Cooverexpressing miR-34b-3p with HCG9 partially suppressed the HCG9-stimulated proliferation, migration, and invasion of osteosarcoma cells in vitro and delayed the tumor progression in vivo. CONCLUSION: We discovered that lncRNA HCG9 promoted the proliferation of osteosarcoma cells via suppressing miR-34b-3p. +transcription factor target 34456629 hsa-mir-489 Sepsis In conclusion, this study presented that Cur prevented GF-triggered renal injury by restraining aerobic glycolysis via the miR-489/LDHA axis in the HEK-293 cell model. +genetics_knock down_promote 34456589 hsa-mir-432 Colorectal Neoplasms CONCLUSION: The results supported the hypothesis that circDUSP16 knockdown suppressed CRC progression by regulating the miR +other 34456588 hsa-mir-126 Ovarian Neoplasms The downregulated expression of miR-199a-3p, miR-199b-3p, miR-199a-5p, miR-126-3p and miR-145-5p in ascites-derived spheroids plays a key role in promoting ovarian cancer progression +other 34456588 hsa-mir-199a Ovarian Neoplasms The downregulated expression of miR-199a-3p, miR-199b-3p, miR-199a-5p, miR-126-3p and miR-145-5p in ascites-derived spheroids plays a key role in promoting ovarian cancer progression +other 34456588 hsa-mir-199b Ovarian Neoplasms The downregulated expression of miR-199a-3p, miR-199b-3p, miR-199a-5p, miR-126-3p and miR-145-5p in ascites-derived spheroids plays a key role in promoting ovarian cancer progression +other 34456588 hsa-mir-145 Ovarian Neoplasms The downregulated expression of miR-199a-3p, miR-199b-3p, miR-199a-5p, miR-126-3p and miR-145-5p in ascites-derived spheroids plays a key role in promoting ovarian cancer progression +other 34456585 hsa-mir-138 Ischemic Stroke 3p and hsa-miR-374a-3p) in IS had regulatory effects on IS-related genes and were involved in brain-related diseases. +other 34456585 hsa-mir-9 Ischemic Stroke 3p and hsa-miR-374a-3p) in IS had regulatory effects on IS-related genes and were involved in brain-related diseases. +other 34456585 hsa-mir-651 Ischemic Stroke 3p and hsa-miR-374a-3p) in IS had regulatory effects on IS-related genes and were involved in brain-related diseases. +genetics_overexpression_suppress 34456566 hsa-mir-23a Glioblastoma The effects of circPTK2 overexpression on miR-23a maturation were analyzed by transfecting circPTK2 expression vector into glioblastoma cells, followed by determining the expression of mature miR-23a and premature miR-23a by RT-qPCR. +other 34456284 hsa-mir-96 Osteoporosis In addition, the expression of MALAT1 significantly decreased whereas that of miR-96 increased in the hBMSCs of osteoporosis (OP) patients. +other 34456284 hsa-mir-96 Adenocarcinoma of Lung OBJECTIVES: To investigate whether and how the long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) sponges microRNA-96 (miR-96) to achieve the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs). Metastasis-associated lung adenocarcinoma transcript 1, miR-96, and osteogenesis-related Messenger RNA expression was assessed by Quantitative Real-time Polymerase Chain Reaction (qRT-PCR). +other 34456284 hsa-mir-96 Osteoporosis-pseudoglioma syndrome In addition, the expression of MALAT1 significantly decreased whereas that of miR-96 increased in the hBMSCs of osteoporosis (OP) patients. +genetics_knock down_suppress 34455968 hsa-mir-152 Carcinoma, Non-Small-Cell Lung 3p expression and that the knockdown of PCGEM1 may inhibit NSCLC cell proliferation, migration and invasion by sponging miR +lncRNA target 34455918 hsa-mir-340 Squamous Cell Carcinoma of Head and Neck Taken together, circPPFIA1 promotes the progression of LSCC via the miR3p/ELK1 signaling axis, which may serve as a novel prognostic or therapeutic target for LSCC. +target gene 34455899 hsa-mir-153 Breast Neoplasms the miRNA-153 inhibited breast cancer growth via regulation of mTORC2 signaling pathway +other 34455717 hsa-mir-11181 Glioblastoma RESULTS: RT-qPCR analysis indicated that both Hsa-miR5p and Has-miR11181-3p specifically up-regulated in higher grades of glioma tumours versus other brain tumour types. +transcription factor target 34455717 hsa-mir-1118 Glioblastoma Due to the high expression of Hsa-miR-11181 in limited glioblastoma brain tumours, in this study we intend to assess the expressions of Hsa-miR-11181 and Has-miR11181-3p in brain tumour tissues and attribute new target genes to these miRNAs. +exosome 34455417 hsa-mir-15a Carcinoma, Hepatocellular Exosomal microRNA-15a from mesenchymal stem cells impedes hepatocellular carcinoma progression via downregulation of SALL4. +lncRNA target 34455220 hsa-mir-148a Stomach Neoplasms CONCLUSION: The study clarified that miR-148a-3p suppressed gastric cancer tumorigenesis by inhibiting CEMIP, which may be effective targets for the clinical treatment of gastric cancer. +other 34455196 hsa-mir-374b Leukemia, Lymphocytic, Chronic, B-Cell 5p, and miR-374b-5p in treatment naive CLL patients here might be suggestive of their modulatory protective role in CLL progression. +other 34455196 hsa-mir-98 Leukemia, Lymphocytic, Chronic, B-Cell 5p, and miR-374b-5p in treatment naive CLL patients here might be suggestive of their modulatory protective role in CLL progression. +other 34455196 hsa-mir-32 Leukemia, Lymphocytic, Chronic, B-Cell 5p, and miR-374b-5p in treatment naive CLL patients here might be suggestive of their modulatory protective role in CLL progression. +lncRNA target 34455059 hsa-mir-138 Alzheimer Disease 5p, providing a possible target for the treatment of diseases characterized by a cognitive deficit. +genetics_GWAS 34455057 hsa-mir-5007 Pulmonary Disease, Chronic Obstructive rs2997119 was associated with the increased risk of COPD in women under multiple genetic models; miR +genetics_GWAS 34455057 hsa-mir-8079 Pulmonary Disease, Chronic Obstructive CONCLUSION: Our results suggested that the genetic polymorphisms of miR-8079 or miR-5007 were potentially associated with COPD risk, of which miR +genetics_overexpression_suppress 34454812 hsa-mir-31 Melanoma 3p inhibitor and EPHA2 overexpression reversed the inhibitory effect of circ_0062270 silencing on melanoma progression. +genetics_overexpression_promote 34454554 hsa-mir-425 Ovarian Neoplasms 5p up-regulation has been proved to partially reverse the tumor suppressive function of MSC-AS1 overexpression CONCLUSION: MSC-AS1 sponged miR +other 34454450 hsa-mir-503 Carcinoma, Non-Small-Cell Lung The interaction between DLGAP1-AS2 and miR-503 was confirmed by dual luciferase reporter assay, and their relationship was explored in NSCLC cells transfected with DLGAP1-AS2 expression vector or miR-503 mimic. CONCLUSIONS: DLGAP1-AS2 may regulate miR-503/cyclin D1 to promote cell proliferation in NSCLC. +other 34454204 hsa-let-7f Amyotrophic Lateral Sclerosis Furthermore, the levels of Let7f-5p, although were generally lowered in ALS patients but were also decreased in familial cases as well as in spinal onset ALS as compared to bulbar onset. +lncRNA target 34454184 hsa-mir-665 Tuberculosis Overall, the preceding observations clearly illuminated that MIAT was elevated in human macrophage response to BCG infection, and functioned as a negative regulator in autophagy and antimicrobial effects by manipulating miR-665/ULK1 axis during Mtb infection, which may provide a promising target for developing an anti-bacterial against TB. +other 34453920 hsa-mir-638 Colorectal Neoplasms CONCLUSION: Our current findings identified the circ-PABPN1/miR-638/SRSF1 axis as a novel anti-tumor mechanism of propofol in CRC, providing a new rationale for developing propofol as a promising therapeutic agent for CRC. +transcription factor target 34453780 hsa-mir-92a Colorectal Neoplasms In conclusion, RBM38 inhibits CRC progression by competitively binding to PTEN 3'UTR with miR-92a-3p. +tissue_expression_ns 34453499 hsa-mir-140 Adenocarcinoma of Lung Upexpression of LINC00894/MMP25-AS1/SNHG1/LINC02298/MIR193BHG and downexpression of miR +transcription factor target 34453123 hsa-mir-548ac Leukemia, Myeloid, Acute Taken together, these results indicated that miR-548ac delivered by AML cell-derived EVs inhibits hematopoiesis via TRIM28-dependent STAT3 activation. +circulation_biomarker_diagnosis_ns 34453104 hsa-mir-132 Fatty Liver Reduction of miR-132 may be a target for the regulation of liver lipid homeostasis and control of obesity-related blood pressure. +circulation_biomarker_diagnosis_ns 34453104 hsa-mir-132 Obesity Reduction of miR-132 may be a target for the regulation of liver lipid homeostasis and control of obesity-related blood pressure. +lncRNA target 34453038 hsa-mir-613 Breast Neoplasms The functional roles of tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ)-DAAM1 axis and their regulator microRNA-613 (miR-613) in BrCa cells and associated molecular mechanisms were demonstrated in vitro. Moreover, miR-613 directly targeted both YWHAZ and DAAM1, contributing to inhibiting BrCa cells migration via blocking the complex of YWHAZ-DAAM1. +genetics_overexpression_promote 34452887 hsa-mir-643 Stomach Neoplasms Moreover, TXNDC9 overexpression reversed the effects of miR-643 mimics on gastric cancer cell viability, invasion, and migration. +genetics_overexpression_promote 34452076 hsa-mir-603 Glioblastoma miR-603 was complexed with PEI, a cationic polymer, and encapsulated into liposomes decorated with polyethylene glycol (PEG) and PR_b, a fibronectin-mimetic peptide that specifically targets the alpha(5)beta(1) integrin that is overexpressed in glioblastomas. +genetics_GWAS 34450377 hsa-mir-421 Pancreatic Carcinoma CONCLUSION: We found an interesting finding that the 73-03 in combination with GCB can improve GCB efficacy and decrease PCa resistance, which induced apoptosis and mitochondrial damage through epigenetic inhibition of SPINK1 transcription by miR-421 up-regulation. +other 34450025 hsa-mir-218 Motor Neuron Disease A non-linearly responsive regulon exhibited a steep miR-218 dose-dependent threshold in repression that, when crossed, resulted in severe motor neuron synaptic failure and death. +circRNA target 34449947 hsa-mir-29 Rift Valley Fever Therefore, circFAM120A modulated decidualization in RIF through the miR-29/ABHD5 axis. +transcription factor target 34449670 hsa-mir-203 Triple Negative Breast Neoplasms We have identified that miRNA-203, silenced by epithelial-mesenchymal transition (EMT), is a tumor suppressor and can promote differentiation of breast cancer stem cells. In this study, we tested the ability of liposomal delivery of miR-203 to reverse aspects of breast cancer pathogenesis using breast cancer and EMT cell lines. +genetics_GWAS 34449560 hsa-mir-22 Myelodysplastic Syndromes In summary, the loss of TET2 function, including both TET2 mutation and high miR-22 expression, was not a good biomarker for predicting the response to HMT but may be associated with lower-risk disease based on IPSS, lower leukemic transformation and longer survival. +genetics_GWAS 34449559 hsa-mir-155 Pre-Eclampsia mir155 can be considered to be one of the genetic biomarkers and can be used as a diagnostic tool for the early detection of PE. +genetics_GWAS 34449559 hsa-mir-155 Chronic Periodontitis mir155 can be considered to be one of the genetic biomarkers and can be used as a diagnostic tool for the early detection of PE. +other 34449141 hsa-mir-181a Seizures, Febrile Although the expression levels of miRNAs-146a, -181a and -155 were higher in febrile seizure patients, only miRNAs 146a level was significantly higher in FS patients. +other 34449141 hsa-mir-155 Seizures, Febrile Although the expression levels of miRNAs-146a, -181a and -155 were higher in febrile seizure patients, only miRNAs 146a level was significantly higher in FS patients. +other 34449141 hsa-mir-146a Seizures, Febrile Although the expression levels of miRNAs-146a, -181a and -155 were higher in febrile seizure patients, only miRNAs 146a level was significantly higher in FS patients. +circulation_biomarker_diagnosis_up 34448795 hsa-mir-146a Osteoarthritis CONCLUSION: The expression levels of plasma miR-146a, miR-365 and inflammatory factors are notably higher, the disease is more severe, and the function of knee joint movement is weaker in OA patients than those in healthy controls. +circulation_biomarker_diagnosis_up 34448795 hsa-mir-365 Osteoarthritis CONCLUSION: The expression levels of plasma miR-146a, miR-365 and inflammatory factors are notably higher, the disease is more severe, and the function of knee joint movement is weaker in OA patients than those in healthy controls. +genetics_overexpression_promote 34448661 hsa-mir-34a Carcinoma, Non-Small-Cell Lung Overexpression of SNHG7 or miR-34a-5p inhibitor promoted NSCLC cell proliferation and accelerated tumor cell growth and metastasis. +lncRNA target 34448644 hsa-mir-200b Asthma NEAT1 acted as the role of sponge for miR-200a/b to regulate MMP-16 expression, thereby promoting asthma progression, suggesting that NEAT1 might have great potential as therapeutic target for asthma. +lncRNA target 34448644 hsa-mir-200a Asthma NEAT1 acted as the role of sponge for miR-200a/b to regulate MMP-16 expression, thereby promoting asthma progression, suggesting that NEAT1 might have great potential as therapeutic target for asthma. +circulation_biomarker_diagnosis_up 34448533 hsa-mir-181a Pancreatitis Expression patterns of MALAT1, microRNA-181a-5p (miR-181a-5p) and high-mobility group box 1 protein (HMGB1) in serum of AP patients were determined. +circulation_biomarker_diagnosis_ns 34448266 hsa-mir-339 Airway Obstruction Increasing miR-339 (above the 0.02 fold change) and galectin-3 (above the 11.7 ng/ml) threshold plasma levels in lung recipients is associated with high risk (RR = 7.14 /- 0.97 [95% CI 1.05-48.60], P = 0.045) of airway obstruction after LTx. +genetics_knock down_suppress 34448115 hsa-mir-4429 Colonic Neoplasms 5p hindered colon cancer cell proliferation, migration, and invasion, whereas knockdown of miR +other 34447534 hsa-mir-155 Carcinoma, Non-Small-Cell Lung Moreover, this nanosensor can accurately quantify miRNA-155 even at the single-cell level, and it can distinguish the miRNA-155 expression in tissues of healthy persons and nonsmall cell lung cancer (NSCLC) patients. +genetics_overexpression_suppress 34447471 hsa-mir-195a Laryngeal Neoplasms Collectively, the findings of the present study demonstrated that the overexpression of miR +genetics_overexpression_suppress 34447471 hsa-mir-195 Laryngeal Neoplasms Collectively, the findings of the present study demonstrated that the overexpression of miR +transcription factor target 34447470 hsa-mir-590 Myocardial Ischemia In summary, the present study showed that miR3p exhibited a protective effect on H/R-induced cardiomyocyte injury and may be a novel target for the treatment of myocardial ischemia disease. +other 34447464 hsa-mir-374a Osteoporosis Overall, findings of the present study suggested that LINC00899 could facilitate the osteogenic differentiation of hBMSCs and prevent osteoporosis by sponging miR-374a to enhance the expression of RUNX2, which provide a potentially useful therapeutic strategy for patients with osteoporosis. +lncRNA target 34446806 hsa-mir-125a Hypogonadism In conclusion, MIR22HG up-regulated NDRG2 expression through targeting miR-125a-5p, thus promoting LC apoptosis in LOH. +lncRNA target 34446703 hsa-mir-629 Breast Neoplasms Therefore, our findings reveal the MIR22HG-dependent inhibition of breast cancer cell proliferation and migration via the miR5p/LATS2 pathway, providing new insights and identifying novel therapeutic targets for breast cancer treatment. +other 34446693 hsa-mir-206 Non-alcoholic Fatty Liver Disease Circ_0057558 acts as a miR-206 sponge to de-repress the ROCK1/AMPK signaling and facilitates lipogenesis and TG secretion, which greatly contributes to NAFLD development and progression. +lncRNA target 34446576 hsa-mir-377 Lung Neoplasms 5 p expression levels, resulting in the upregulation of their common downstream target programmed death-ligand 1 (PD-L1), a crucial target in LC immunotherapy. +lncRNA target 34446576 hsa-mir-155 Lung Neoplasms 5 p expression levels, resulting in the upregulation of their common downstream target programmed death-ligand 1 (PD-L1), a crucial target in LC immunotherapy. +other 34446467 hsa-mir-26a Asthma CONCLUSION: Collectively, we identified miR-125b-5p, miR3p and miR-26a-5p as potential regulators that could contribute to the pathogenesis of asthma. +lncRNA target 34446134 hsa-mir-20a Stomach Neoplasms Bioinformatics was used via differential expression analysis, weighted gene co-expression network analysis, gene set enrichment analysis, and a training support vector machine (SVM) model to construct a TSIX/mir-320a/Rad51 network as the research index of GAC disease. TSIX/miR-320a/Rad51 network may be a potential biological target of GAC disease and provides a new strategy for treating GAC disease. +other 34446131 hsa-mir-92a Acute Lung Injury miRNA-92a (miR92a) is induced in the lungs of ALI patients and mediates inflammatory reactions. In this study, a RP1-linked R3V6 (RP1R3V6) peptide was synthesized and evaluated as a carrier of anti-microRNA-92a oligonucleotide (AMO92a) into the lungs of an ALI animal model. +lncRNA target 34446088 hsa-mir-135a Inflammation CONCLUSIONS: In conclusion, CASC2 alleviated proliferation, inflammation and fibrosis in DN cell model by sponging miR-135a-5p to induce TIMP3 expression. +lncRNA target 34446088 hsa-mir-135a Diabetic Nephropathies CONCLUSIONS: In conclusion, CASC2 alleviated proliferation, inflammation and fibrosis in DN cell model by sponging miR-135a-5p to induce TIMP3 expression. +other 34445994 hsa-mir-29b Carcinoma, Hepatocellular miR-29b/c-CCNA2 axes served as molecular stimuli for HCC advance. +other 34445994 hsa-mir-29c Carcinoma, Hepatocellular miR-29b/c-CCNA2 axes served as molecular stimuli for HCC advance. +other 34445712 hsa-mir-377 Heart Failure Pre-miRNA-377 is a hairpin-shaped regulatory RNA associated with heart failure. +lncRNA target 34445350 hsa-mir-181b Cerebral Intraventricular Hemorrhage Furthermore, human choroid plexus epithelial cells (HCPEpiCs) were incubated with IVH and non-IVH CSF (10 v/v %) for 24 h in vitro to investigate the IVH-induced inflammatory response that was investigated via: (i) HMOX1, IL8, VCAM1, and ICAM1 mRNAs as well as miR-155, miR-223, and miR-181b levels by RT-qPCR; (ii) nuclear translocation of the NF-kappaB p65 subunit by fluorescence microscopy; and (iii) reactive oxygen species (ROS) measurement. IVH-III with higher miR-155 and miR-181b expression at days 41-60. +lncRNA target 34445350 hsa-mir-155 Cerebral Intraventricular Hemorrhage Furthermore, human choroid plexus epithelial cells (HCPEpiCs) were incubated with IVH and non-IVH CSF (10 v/v %) for 24 h in vitro to investigate the IVH-induced inflammatory response that was investigated via: (i) HMOX1, IL8, VCAM1, and ICAM1 mRNAs as well as miR-155, miR-223, and miR-181b levels by RT-qPCR; (ii) nuclear translocation of the NF-kappaB p65 subunit by fluorescence microscopy; and (iii) reactive oxygen species (ROS) measurement. IVH-III with higher miR-155 and miR-181b expression at days 41-60. +other 34445337 hsa-mir-126 Pulmonary Fibrosis Over-expression of miR3p reduces EndMT, therefore, it could be considered for miRNA-based therapeutics in fibrotic organs. +lncRNA target 34445304 hsa-mir-326 Diabetes Mellitus The repression of Srrm4 expression is presumably mediated via a higher expression of miR +lncRNA target 34445304 hsa-mir-3547 Diabetes Mellitus The repression of Srrm4 expression is presumably mediated via a higher expression of miR +genetics_overexpression_promote 34445087 hsa-mir-1 Mouth Neoplasms Overexpression of MIR31HG and of miR-31 occurs during oral squamous cell carcinoma (OSCC). +other 34443415 hsa-mir-34a Uterine Cervical Neoplasms The anti-proliferation and anti-migration effects were tested after the miR-34a transfection to evaluate the anti-tumor response, using human cervical carcinoma cell line HeLa as a model. +other 34443215 hsa-mir-126 Periodontitis The present study aims to compare the levels of micro-RNA-146a and micro-RNA-126 in oral subgingival plaque and coronary plaque from artery walls in patients with coronary artery disease who suffer from generalized periodontitis. miRNA-146a and miRNA-126 were present in coronary artery disease patients with periodontitis. +other 34443215 hsa-mir-126 Coronary Artery Disease The present study aims to compare the levels of micro-RNA-146a and micro-RNA-126 in oral subgingival plaque and coronary plaque from artery walls in patients with coronary artery disease who suffer from generalized periodontitis. miRNA-146a and miRNA-126 were present in coronary artery disease patients with periodontitis. +other 34443215 hsa-mir-146a Coronary Artery Disease The present study aims to compare the levels of micro-RNA-146a and micro-RNA-126 in oral subgingival plaque and coronary plaque from artery walls in patients with coronary artery disease who suffer from generalized periodontitis. miRNA-146a and miRNA-126 were present in coronary artery disease patients with periodontitis. +other 34443215 hsa-mir-146a Periodontitis The present study aims to compare the levels of micro-RNA-146a and micro-RNA-126 in oral subgingival plaque and coronary plaque from artery walls in patients with coronary artery disease who suffer from generalized periodontitis. miRNA-146a and miRNA-126 were present in coronary artery disease patients with periodontitis. +genetics_GWAS 34442609 hsa-mir-1 Colorectal Neoplasms Patients with CRC that had unmethylation of MLH1 and MSH2 showed significantly higher buffy coat ctKRAS G12D mutations, ascites ctKRAS G12D mutations, miR5, and mixed scores than the patients with a methylation of MLH1 and MSH2. +other 34442460 hsa-let-7a Breast Neoplasms 3p (EFS p = 0.05; OS p = 0.01), and miR-199a-3p (EFS p = 0.02; OS p = 0.01) in post-NAC samples, independently from breast cancer subtypes. +other 34442460 hsa-mir-100 Breast Neoplasms 3p (EFS p = 0.05; OS p = 0.01), and miR-199a-3p (EFS p = 0.02; OS p = 0.01) in post-NAC samples, independently from breast cancer subtypes. +other 34442460 hsa-mir-101 Breast Neoplasms 3p (EFS p = 0.05; OS p = 0.01), and miR-199a-3p (EFS p = 0.02; OS p = 0.01) in post-NAC samples, independently from breast cancer subtypes. +other 34442460 hsa-mir-199a Breast Neoplasms 3p (EFS p = 0.05; OS p = 0.01), and miR-199a-3p (EFS p = 0.02; OS p = 0.01) in post-NAC samples, independently from breast cancer subtypes. +other 34441345 hsa-mir-196b Precancerous Conditions CONCLUSION: Salivary miR-196b could be an excellent biomarker for diagnosing OPC and early detection of HNSC. +other 34441345 hsa-mir-196b Squamous Cell Carcinoma of Head and Neck CONCLUSION: Salivary miR-196b could be an excellent biomarker for diagnosing OPC and early detection of HNSC. +transcription factor target 34440920 hsa-mir-193a Prostatic Neoplasms Taken together, these findings support evidence that CK induces apoptosis via the activation of miR193a-5p and inhibition of PD-L1 and STAT3 signaling in prostate cancer cells. +lncRNA target 34440873 hsa-mir-135a Infertility, Female Taken together, our study reveals a pro-survival mechanism of ESR2/miR-135a/Tgfbr1/Ccnd2 axis for GC growth, and also provides a novel target for the improvement of female fertility. +lncRNA target 34440860 hsa-mir-34a Lung Neoplasms However, miR-34a-5p mediated targeting of these molecular networks will provide a better therapeutic intervention for NSCLC. +other 34440834 hsa-mir-193a Colorectal Neoplasms Hence, in the present study, the underlying apoptotic mechanism of Morusin was explored in association with miR193a-5p mediated ZNF746/c-Myc signaling axis in colorectal cancer cells (CRCs). +other 34440757 hsa-mir-195 Carcinoma, Non-Small-Cell Lung In the present study, miRNAs (let-7c, miR-26a, miR-30d, miR-98, miR-195, miR-202) reported to be involved in the polarization of macrophages were examined for associations with the outcomes of non-small cell lung cancer (NSCLC) patients (N = 125) treated with first-line platinum-based chemotherapy. +other 34440757 hsa-mir-98 Carcinoma, Non-Small-Cell Lung In the present study, miRNAs (let-7c, miR-26a, miR-30d, miR-98, miR-195, miR-202) reported to be involved in the polarization of macrophages were examined for associations with the outcomes of non-small cell lung cancer (NSCLC) patients (N = 125) treated with first-line platinum-based chemotherapy. +other 34440757 hsa-mir-26a Carcinoma, Non-Small-Cell Lung In the present study, miRNAs (let-7c, miR-26a, miR-30d, miR-98, miR-195, miR-202) reported to be involved in the polarization of macrophages were examined for associations with the outcomes of non-small cell lung cancer (NSCLC) patients (N = 125) treated with first-line platinum-based chemotherapy. +other 34440757 hsa-mir-202 Carcinoma, Non-Small-Cell Lung In the present study, miRNAs (let-7c, miR-26a, miR-30d, miR-98, miR-195, miR-202) reported to be involved in the polarization of macrophages were examined for associations with the outcomes of non-small cell lung cancer (NSCLC) patients (N = 125) treated with first-line platinum-based chemotherapy. +other 34440757 hsa-let-7c Carcinoma, Non-Small-Cell Lung In the present study, miRNAs (let-7c, miR-26a, miR-30d, miR-98, miR-195, miR-202) reported to be involved in the polarization of macrophages were examined for associations with the outcomes of non-small cell lung cancer (NSCLC) patients (N = 125) treated with first-line platinum-based chemotherapy. +other 34440664 hsa-mir-24 Diabetes Mellitus, Type 2 CONCLUSIONS: We suggest that GA decreases TRPM6 expression mediated by the elevation of ROS and miR3p in renal tubular epithelial cells of T2D. +other 34440625 hsa-mir-29b Carcinoma, Pancreatic Ductal We also identified miR-29a-3p, miR-29b-3p, and miR5p as downregulated miRNAs in PDAC tissues as compared with normal tissues but not with pancreatitis tissues. +other 34440625 hsa-mir-7 Carcinoma, Pancreatic Ductal We also identified miR-29a-3p, miR-29b-3p, and miR5p as downregulated miRNAs in PDAC tissues as compared with normal tissues but not with pancreatitis tissues. +other 34440625 hsa-mir-100 Carcinoma, Pancreatic Ductal 5p were exclusively downregulated in PDAC tissue but not in chronic pancreatitis or normal pancreatic tissues; both control types presented similar levels. +other 34440625 hsa-mir-145 Carcinoma, Pancreatic Ductal 5p were exclusively downregulated in PDAC tissue but not in chronic pancreatitis or normal pancreatic tissues; both control types presented similar levels. +other 34440625 hsa-mir-29c Carcinoma, Pancreatic Ductal 5p were exclusively downregulated in PDAC tissue but not in chronic pancreatitis or normal pancreatic tissues; both control types presented similar levels. +other 34440625 hsa-mir-29a Carcinoma, Pancreatic Ductal We also identified miR-29a-3p, miR-29b-3p, and miR5p as downregulated miRNAs in PDAC tissues as compared with normal tissues but not with pancreatitis tissues. +lncRNA target 34440380 hsa-mir-424 Triple Negative Breast Neoplasms 5p can inhibit tumoral PD-L1 expression, transform immunosuppressive tumor microenvironment into the pro-inflammatory tumor microenvironment, inhibit tumor proliferation, suppress tumor migration, enhance chemosensitivity of tumoral cells, stimulate tumor apoptosis, arrest cell cycle, repress the clonogenicity of tumoral cells, and regulate various oncogenic signaling pathways in TNBC cells. +lncRNA target 34440380 hsa-mir-200c Triple Negative Breast Neoplasms 5p can inhibit tumoral PD-L1 expression, transform immunosuppressive tumor microenvironment into the pro-inflammatory tumor microenvironment, inhibit tumor proliferation, suppress tumor migration, enhance chemosensitivity of tumoral cells, stimulate tumor apoptosis, arrest cell cycle, repress the clonogenicity of tumoral cells, and regulate various oncogenic signaling pathways in TNBC cells. +lncRNA target 34440380 hsa-mir-138 Triple Negative Breast Neoplasms 5p can inhibit tumoral PD-L1 expression, transform immunosuppressive tumor microenvironment into the pro-inflammatory tumor microenvironment, inhibit tumor proliferation, suppress tumor migration, enhance chemosensitivity of tumoral cells, stimulate tumor apoptosis, arrest cell cycle, repress the clonogenicity of tumoral cells, and regulate various oncogenic signaling pathways in TNBC cells. +lncRNA target 34440380 hsa-mir-570 Triple Negative Breast Neoplasms 5p can inhibit tumoral PD-L1 expression, transform immunosuppressive tumor microenvironment into the pro-inflammatory tumor microenvironment, inhibit tumor proliferation, suppress tumor migration, enhance chemosensitivity of tumoral cells, stimulate tumor apoptosis, arrest cell cycle, repress the clonogenicity of tumoral cells, and regulate various oncogenic signaling pathways in TNBC cells. +lncRNA target 34440380 hsa-mir-34a Triple Negative Breast Neoplasms 5p can inhibit tumoral PD-L1 expression, transform immunosuppressive tumor microenvironment into the pro-inflammatory tumor microenvironment, inhibit tumor proliferation, suppress tumor migration, enhance chemosensitivity of tumoral cells, stimulate tumor apoptosis, arrest cell cycle, repress the clonogenicity of tumoral cells, and regulate various oncogenic signaling pathways in TNBC cells. +lncRNA target 34440380 hsa-mir-497 Triple Negative Breast Neoplasms 5p can inhibit tumoral PD-L1 expression, transform immunosuppressive tumor microenvironment into the pro-inflammatory tumor microenvironment, inhibit tumor proliferation, suppress tumor migration, enhance chemosensitivity of tumoral cells, stimulate tumor apoptosis, arrest cell cycle, repress the clonogenicity of tumoral cells, and regulate various oncogenic signaling pathways in TNBC cells. +other 34440358 hsa-let-7a Fabry Disease RESULTS: In a micro-RNA screen of three Fabry patients undergoing enzyme replacement therapy, we found that miRNAs let-7a and let-7d were significantly increased after therapy. CONCLUSION: We suggest that let-7a and let-7d are potential markers for enzyme activity and inflammation in Fabry disease patients. +other 34440358 hsa-let-7d Fabry Disease RESULTS: In a micro-RNA screen of three Fabry patients undergoing enzyme replacement therapy, we found that miRNAs let-7a and let-7d were significantly increased after therapy. CONCLUSION: We suggest that let-7a and let-7d are potential markers for enzyme activity and inflammation in Fabry disease patients. +other 34440258 hsa-mir-122 Cardiovascular Diseases 5p during incident ischemia may be possible risk factors of secondary cardiovascular event(s). +circulation_biomarker_diagnosis_ns 34440258 hsa-mir-375 Cardiovascular Diseases Levels of circulating miRs (miR +circulation_biomarker_diagnosis_ns 34440258 hsa-mir-133b Cardiovascular Diseases Levels of circulating miRs (miR +circulation_biomarker_diagnosis_ns 34440258 hsa-mir-134 Cardiovascular Diseases Levels of circulating miRs (miR +circulation_biomarker_diagnosis_ns 34440258 hsa-mir-499 Cardiovascular Diseases Levels of circulating miRs (miR +circulation_biomarker_diagnosis_ns 34440258 hsa-mir-34a Cardiovascular Diseases Levels of circulating miRs (miR +circulation_biomarker_diagnosis_ns 34440258 hsa-mir-208b Cardiovascular Diseases Levels of circulating miRs (miR +other 34440258 hsa-mir-1 Cardiovascular Diseases 5p during incident ischemia may be possible risk factors of secondary cardiovascular event(s). +circulation_biomarker_diagnosis_ns 34440258 hsa-mir-124 Cardiovascular Diseases Levels of circulating miRs (miR +other 34440258 hsa-mir-16 Cardiovascular Diseases 5p during incident ischemia may be possible risk factors of secondary cardiovascular event(s). +circulation_biomarker_diagnosis_ns 34440128 hsa-mir-33a Carotid Stenosis Methods: In human carotid stenosis arterial tissues and plasma, the expression of ABCA1 and its target miRNAs (miRNA-33a-5p, 33b-5p, and 148a-3p) were evaluated by quantitative real time-polymerase chain reaction (qRT-PCR), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Conclusions: Therefore, miRNA-33a-5p, 33b-5p, and 148a-3p represent possible biomarkers of carotid artery stenosis by directly targeting ABCA1. +circulation_biomarker_prognosis_ns 34440094 hsa-mir-21 Carcinoma, Hepatocellular We aim at evaluating miR-21 and miR-122 in HCC patients treated with drug-eluting beads transarterial chemoembolization (DEB-TACE) as prognostic biomarkers and investigating their correlation with hypoxia inducible factor-1alpha (HIF-1alpha) serum levels. +other 34440094 hsa-mir-122 Carcinoma, Hepatocellular "RESULTS: The highest level of miR-21 was found in cirrhotics, while HCC patients had the highest level of miR-122 (which was even higher in ""viral"" HCC, p = 0.006)." +other 34440082 hsa-mir-6803 Obesity 3p negatively and all obesity indicators positively. +circulation_biomarker_diagnosis_ns 34440064 hsa-mir-145 Hypertension These drugs appear to be able to modify miRs 221/222 and miR-145 expression in drug-nave hypertensives, making it closer to that of control subjects; additionally, this provides a good blood pressure compensation, contributing to slow the progression of vascular damage. +circulation_biomarker_diagnosis_ns 34440064 hsa-mir-222 Hypertension These drugs appear to be able to modify miRs 221/222 and miR-145 expression in drug-nave hypertensives, making it closer to that of control subjects; additionally, this provides a good blood pressure compensation, contributing to slow the progression of vascular damage. +circulation_biomarker_diagnosis_ns 34440025 hsa-mir-133a Lung Neoplasms Cancer and lung-cancer-enriched pathways were significantly associated with the three miRNAs; in addition, nicotinate/nicotinamide metabolism, inflammation, and pulmonary hypertension were associated with miR-133a-3p. Our findings highlight how cigarette smoking affects the reliable identification of circulating miRNAs as diagnostic biomarkers in lung cancer and suggest a smoking-dependent pathogenic role of miR-133a-3p in smokers. +other 34440025 hsa-mir-532 Lung Neoplasms 3p discriminated AD/CS+ patients from H/CS+ controls (AUC: 0.779), and miR-133a discriminated AD/CS+ patients from H/CS+ controls with the highest AUC of 0.935. +other 34440025 hsa-mir-25 Lung Neoplasms 3p discriminated AD/CS+ patients from H/CS+ controls (AUC: 0.779), and miR-133a discriminated AD/CS+ patients from H/CS+ controls with the highest AUC of 0.935. +genetics_knock down_promote 34439496 hsa-mir-29a Osteoporosis Taken together, miR-29a promotes Oxr1, compromising oxidative stress and FoxO3 loss to delay osteoblast aging and bone loss. +exosome 34439276 hsa-mir-21 Esophageal Squamous Cell Carcinoma Esophageal Cancer-Derived Extracellular Vesicle miR-21-5p Contributes to EMT of ESCC Cells by Disorganizing Macrophage Polarization. +other 34439151 hsa-mir-200c Biliary Tract Neoplasms In this study, we explored the influence of the EMT-regulating miR-200c-3p on cisplatin sensitivity in biliary tract cancer cells. In conclusion, miR-200c-3p might be an important contributor to cisplatin resistance in biliary tract cancer, independently of its interaction with ZEB1. +lncRNA target 34438465 hsa-mir-515 Colorectal Neoplasms CONCLUSIONS: circ_0040809 facilitates CRC cell proliferation and migration, and inhibits apoptosis, through modulating miR +transcription factor target 34438336 hsa-mir-26a osteogenesis imperfecta type 1 This study aimed to identify the role of miR-26a in osteoclastogenesis and orthodontically induced inflammatory root resorption(OIIRR). CONCLUSION: We concluded that Runx1/miR-26a/Jagged1 signaling axis restrained osteoclastogenesis and alleviated OIIRR. +genetics_overexpression_suppress 34438336 hsa-mir-26a Otitis Media Furthermore, miR-26a overexpression inhibited the osteoclastogenesis and rescued the root resorption in OTM rats through inhibition of Jagged1. +other 34438336 hsa-mir-26a Root Resorption This study aimed to identify the role of miR-26a in osteoclastogenesis and orthodontically induced inflammatory root resorption(OIIRR). +lncRNA target 34437815 hsa-mir-4677 Stomach Neoplasms siCEMIP or PI3K/AKT signaling inhibitor (Akti-1/2 and LY294002) partly reversed the effects of miR +other 34437807 hsa-mir-200c Bone Diseases These results strongly indicate that bone grafts combining SEPS 3D-printed osteoconductive biomaterial-based scaffolds with osteoinductive miR-200c can be used as superior bone substitutes for the clinical treatment of large bone defects. +genetics_GWAS 34437653 hsa-mir-146a Hepatitis B, Chronic In the current study, we aimed to assess rs767649 T/A and rs57095329 A/G polymorphisms in miR-155, and miR-146a genes, respectively, as risk factors for Chronic HBV (CHBV) in the Egyptian population. One hundred patients diagnosed as CHBV and one hundred age and sex-matched controls with evidence of past HBV infection were genotyped for miR-155 (rs767649) and miR-146a (rs57095329) using real-time polymerase chain reaction. +genetics_GWAS 34437653 hsa-mir-155 Hepatitis B, Chronic In the current study, we aimed to assess rs767649 T/A and rs57095329 A/G polymorphisms in miR-155, and miR-146a genes, respectively, as risk factors for Chronic HBV (CHBV) in the Egyptian population. One hundred patients diagnosed as CHBV and one hundred age and sex-matched controls with evidence of past HBV infection were genotyped for miR-155 (rs767649) and miR-146a (rs57095329) using real-time polymerase chain reaction. +lncRNA target 34436746 hsa-mir-1306 Iron Metabolism Disorders These results suggested that H19 silencing alleviated OGD/R-triggered I/R injury at least partially depending on the regulation of the miR5p/BCL2L13 axis. +genetics_knock down_promote 34435652 hsa-mir-26a Squamous Cell Carcinoma of Head and Neck Collectively, the present study demonstrated that NORAD knockdown attenuated the migration, invasion and EMT of HNSCC stem cells via miR26a5p. +genetics_overexpression_promote 34435649 hsa-mir-101a Atrial Fibrillation Immunohistochemistry for collagen and collagen III revealed a reduction in atrial collagen synthesis following miR101a3p overexpression in AF model rats. +circulation_biomarker_diagnosis_down 34435593 hsa-mir-342 Myocardial Infarction, Acute 3p in plasma exosomes might be responsible for their impaired cardioprotective potential. +lncRNA target 34435542 hsa-mir-370 Glioblastoma CONCLUSION: Silencing of LINC01410 inhibits cell viability yet enhances apoptosis and sensitivity to TMZ in GBM cells by inactivating PTEN/AKT pathway via targeting miR +genetics_knock down_promote 34435526 hsa-mir-93 Carcinoma, Hepatocellular 5p knockdown repressed the progression of HCC via increasing ERBB4 and TETs-dependent DNA demethylation. +circulation_biomarker_diagnosis_up 34435525 hsa-mir-146b Lesch-Nyhan Syndrome This study revealed that miR-146b-5p level was declined and IFI35 abundance was elevated in serum of LN patients and LPS-challenged HK-2 cells. +genetics_overexpression_promote 34435522 hsa-mir-196b Neoplasms, Multiple Primary The upregulation of miRNA-196a, miRNA-196b and miRNA-196 expression is correlated with significantly unfavorable OS in multiple malignancies; similarly, miRNA-196 overexpression predicts poor PFS in multiple malignancies. Taken together, these findings indicate that miRNA-196a and miRNA-196b may serve as oncogenic molecules and may be potential prognostic biomarkers in multiple malignancies. +genetics_overexpression_promote 34435522 hsa-mir-196b Abnormalities, Multiple The upregulation of miRNA-196a, miRNA-196b and miRNA-196 expression is correlated with significantly unfavorable OS in multiple malignancies; similarly, miRNA-196 overexpression predicts poor PFS in multiple malignancies. Taken together, these findings indicate that miRNA-196a and miRNA-196b may serve as oncogenic molecules and may be potential prognostic biomarkers in multiple malignancies. +genetics_overexpression_promote 34435522 hsa-mir-196a Abnormalities, Multiple The upregulation of miRNA-196a, miRNA-196b and miRNA-196 expression is correlated with significantly unfavorable OS in multiple malignancies; similarly, miRNA-196 overexpression predicts poor PFS in multiple malignancies. +genetics_overexpression_promote 34435522 hsa-mir-196a Neoplasms, Multiple Primary The upregulation of miRNA-196a, miRNA-196b and miRNA-196 expression is correlated with significantly unfavorable OS in multiple malignancies; similarly, miRNA-196 overexpression predicts poor PFS in multiple malignancies. Taken together, these findings indicate that miRNA-196a and miRNA-196b may serve as oncogenic molecules and may be potential prognostic biomarkers in multiple malignancies. +genetics_overexpression_promote 34435522 hsa-mir-196 Neoplasms, Multiple Primary The upregulation of miRNA-196a, miRNA-196b and miRNA-196 expression is correlated with significantly unfavorable OS in multiple malignancies; similarly, miRNA-196 overexpression predicts poor PFS in multiple malignancies. Taken together, these findings indicate that miRNA-196a and miRNA-196b may serve as oncogenic molecules and may be potential prognostic biomarkers in multiple malignancies. +genetics_overexpression_promote 34435522 hsa-mir-196 Abnormalities, Multiple The upregulation of miRNA-196a, miRNA-196b and miRNA-196 expression is correlated with significantly unfavorable OS in multiple malignancies; similarly, miRNA-196 overexpression predicts poor PFS in multiple malignancies. +lncRNA target 34435328 hsa-mir-143 Ischemic Stroke Our results demonstrated for the first time that circ_0025984 protects astrocytes from ischemia-induced autophagy and apoptosis by targeting the miR +lncRNA target 34435325 hsa-mir-466 Stomach Neoplasms The present study provides novel evidence for the clinical and biological significance of miR-466 expression as a possible biomarker for the prognosis and identifying patients with peritoneal metastasis, as well as a potential therapeutic target in patients with gastric cancer. +lncRNA target 34435195 hsa-mir-144 Carcinoma, Non-Small-Cell Lung 3p suppresses NSCLC development by inhibiting CEP55 expression. +transcription factor target 34435140 hsa-mir-4521 Carcinoma, Non-Small-Cell Lung CONCLUSION: The results of this study showed that the low expression of miR-4521 indicated the poor prognosis of NSCLC and promoted cell proliferation, migration, and invasion by targeting FOXM1. +lncRNA target 34435045 hsa-mir-129 Myocardial Reperfusion Injury miR-129 is an important biomarker for MIRI, as well as a potential therapy target. +other 34434963 hsa-mir-30 Osteoporosis Additional experiments showed that Tnc regulated Wnt/beta-catenin signaling, and rescue experiment showed that miR5p could restore beta-catenin expression; additionally, animal experiments indicated that Wnt signaling was inactivated in the ovariectomized rats. +circulation_biomarker_diagnosis_ns 34434498 hsa-mir-16 Liver Cirrhosis 5p showed strong association with liver cancer in plasma. +circulation_biomarker_diagnosis_ns 34434498 hsa-let-7a Liver Neoplasms 3p - in plasma and saliva of patients with HCV-related liver cirrhosis (n = 24), primary liver cancer (n = 24) and healthy volunteers (n = 21). +circulation_biomarker_diagnosis_ns 34434498 hsa-mir-21 Liver Neoplasms 5p showed strong association with liver cancer in plasma. +circulation_biomarker_diagnosis_ns 34434498 hsa-let-7a Liver Cirrhosis 3p - in plasma and saliva of patients with HCV-related liver cirrhosis (n = 24), primary liver cancer (n = 24) and healthy volunteers (n = 21). +circulation_biomarker_diagnosis_ns 34434498 hsa-mir-16 Liver Neoplasms 5p showed strong association with liver cancer in plasma. +circulation_biomarker_diagnosis_ns 34434498 hsa-mir-21 Liver Cirrhosis 5p showed strong association with liver cancer in plasma. +circulation_biomarker_diagnosis_up 34434493 hsa-mir-21 Pancreatic Carcinoma The combination of miRNAs-21, -210 tissue expression and serum CA19-9 showed 100% accuracy in the diagnosis of PA, as well as miR-181c expression in the plasma (PApxPCp). +lncRNA target 34434273 hsa-mir-139 Sepsis 5p alleviated sepsis-induced ALI via suppression of its downstream target, ROCK1, suggesting that miR +lncRNA target 34434273 hsa-mir-139 Lung Injury 5p alleviated sepsis-induced ALI via suppression of its downstream target, ROCK1, suggesting that miR +other 34434263 hsa-mir-150 Sepsis Although microRNA-150 (miR-150) has been previously reported to be involved in the modulation of sepsis, the underlying molecular mechanism in sepsis remains poorly understood. In the present study, the human monocytic cell line THP-1 was treated with LPS to mimic sepsis in vitro, following which miR-150 and STAT1 expression were measured using reverse transcription-quantitative PCR or western blotting. +target gene 34434261 hsa-mir-483 Triple Negative Breast Neoplasms Inhibition of miR-483-5p improves the proliferation, invasion and inflammatory response of triple-negative breast cancer cells by targeting SOCS3. +target gene 34434057 hsa-mir-130b Breast Neoplasms HOTAIR Facilitates Endocrine Resistance in Breast Cancer Through ESR1/miR-130b-3p Axis: Comprehensive Analysis of mRNA-miRNA-lncRNA Network. +other 34433636 hsa-mir-379 Prostatic Neoplasms We found that the miR-379 editing frequency was higher in prostate cancer samples compared to benign prostatic hyperplasia samples. +other 34433636 hsa-mir-379 Prostatic Hyperplasia We found that the miR-379 editing frequency was higher in prostate cancer samples compared to benign prostatic hyperplasia samples. +transcription factor target 34433394 hsa-mir-1297 Rhabdomyosarcoma 1 Besides, we constructed miRNA-mRNA network between DEMs target genes and DEGs in RM, including hsa-miR KLHL24 and hsa-miR-548a-5p-KLHL24 pairs. +genetics_overexpression_promote 34433333 hsa-mir-137 Arthritis, Rheumatoid Next, experiments involving miR-137 overexpression were performed to analyze the role of miR-137 in human fibroblast-like synoviocytes-RA (HFLS-RA) using cell counting kit-8 (CCK-8) assay, EdU staining, Transwell assay and flow cytometry, respectively. +lncRNA target 34433131 hsa-mir-146b Breast Neoplasms Fluorescence in situ hybridization, double luciferase reporter gene analysis, RNA pull-down and RNA immunoprecipitation experiments were performed to explore the correlation of circ_RPPH1 with miR-146b-3p/E2F2 in BC. CONCLUSION: Circ_RPPH1/miR-146b-3p/E2F2 axis can promote the progression of BC, and it might be a latent therapeutic target for clinical BC. +genetics_knock down_suppress 34432784 hsa-mir-204 Melanoma 5p, and an inhibitory effect of FOXC1 knockdown on melanoma cell proliferation were revealed. +transcription factor target 34432732 hsa-mir-19 Pelvic Organ Prolapse 3p may affect the synthesis of Col-1 by targeting IGF-1 and that it may play an vital role in POP. +lncRNA target 34431595 hsa-mir-155 Sepsis 5p/WWC1 axis modulated sepsis-induced AKI progression, providing promising insight into therapeutic targets for sepsis-induced AKI. +lncRNA target 34431595 hsa-mir-155 Acute Kidney Injury 5p/WWC1 axis modulated sepsis-induced AKI progression, providing promising insight into therapeutic targets for sepsis-induced AKI. +genetics_overexpression_promote 34431454 hsa-mir-199a Hyperuricemic Nephropathy Collectively, overexpression of miR-199a aggravated the renal injury in HN rats. +lncRNA target 34431444 hsa-mir-92a Prostatic Neoplasms MiR-92a might play a key role in regulating the proliferation, migration and invasion of PCa cells through the PTEN/Akt signaling pathway. +circRNA target 34431434 hsa-mir-132 Arthritis, Rheumatoid In conclusion, the protective effect of Circ-Sirt1 on MH7A depends on inhibiting cell proliferation, promoting apoptosis and miRmediated Sirt1 pathway to reduce inflammation. +lncRNA target 34431433 hsa-mir-185 Osteoporosis-pseudoglioma syndrome CONCLUSION: Our study elaborated that PART1/miR5p/RUNX3 feedback contributed to osteogenic differentiation and inhibited the hBMSCs apoptosis, suggesting that PART1 might be a novel target for OP treatment. +lncRNA target 34431405 hsa-mir-1 Pyloric Hypomotility pylori infection was associated with reduced miR-1, epithelial to mesenchymal transition, and pyloric hypomotility. Targeting miR-1 could be valuable in the clinical management of pyloric hypofunction. +other 34431214 hsa-mir-363 Graves Disease 5p may play an important role in Treg cell dysfunction and immune tolerance abnormalities in GD patients. +lncRNA target 34431162 hsa-mir-296 Carcinoma, Renal Cell In conclusion, our study indicated that HSPB1P1 contributed to RCC progression by targeting the miR5p/HMGA1 axis, and should be considered as a promising biomarker and therapeutic target for clinical applications. +genetics_knock down_promote 34431160 hsa-mir-98 Osteoporosis, Postmenopausal In summary, M1Mphi-derived exosomal miR-98 exacerbates bone loss and OP by downregulating DUSP1 and activating the JNK signaling pathway. miR-98 may therefore serve as a therapeutic target in OP management. +lncRNA target 34431063 hsa-mir-127 Carcinoma, Hepatocellular To conclude, this research reported that MSC-derived Exo block malignant behaviors of HCC-sourced CSCs through a C5orf66-AS1/miR3p/DUSP1/ERK axis. +lncRNA target 34431044 hsa-mir-1273g Prostatic Neoplasms In total, miR-1273 g-3p was increased in PCa and identified as a therapeutic target and a prognostic factor for PCa patients. +target gene 34430707 hsa-mir-130a Parkinson Disease HAGLR promotes neuron differentiation through the miR-130a-3p-MeCP2 axis. +lncRNA target 34430706 hsa-mir-128 Sepsis 3p enabled to alleviate sepsis-induced ALI by inhibiting PEL12 expression, indicating a novel treatment strategy of miR +lncRNA target 34430706 hsa-mir-128 Acute Lung Injury 3p enabled to alleviate sepsis-induced ALI by inhibiting PEL12 expression, indicating a novel treatment strategy of miR +other 34430597 hsa-mir-4433b Polycystic Ovary Syndrome 3p, hsa-miR-1231, hsa-miR-3609, and hsa-miR-4433b-3p. +other 34430597 hsa-mir-135b Polycystic Ovary Syndrome 3p, hsa-miR-1231, hsa-miR-3609, and hsa-miR-4433b-3p. +other 34430597 hsa-mir-1231 Polycystic Ovary Syndrome 3p, hsa-miR-1231, hsa-miR-3609, and hsa-miR-4433b-3p. +other 34430597 hsa-mir-4649 Polycystic Ovary Syndrome 3p, hsa-miR-1231, hsa-miR-3609, and hsa-miR-4433b-3p. +other 34430597 hsa-mir-609 Polycystic Ovary Syndrome 3p, hsa-miR-1231, hsa-miR-3609, and hsa-miR-4433b-3p. +lncRNA target 34430434 hsa-mir-424 Hemangioma, Cavernous We aimed to explore the effect of propranolol on the expression of microRNA (miR)-424 in IHA tissues and XPTS-1 cells, as well as its molecular mechanism of inhibiting XPTS-1 cell activity. +other 34430428 hsa-mir-7 Azoospermia AKT3-related miRNAs, including hsa-miR5p and hsa-miR-519d-3p, might be responsible for cryptorchidism and cryptorchidism-induced azoospermia and serve as potential biomarkers. +other 34430428 hsa-mir-519d Azoospermia AKT3-related miRNAs, including hsa-miR5p and hsa-miR-519d-3p, might be responsible for cryptorchidism and cryptorchidism-induced azoospermia and serve as potential biomarkers. +genetics_overexpression_promote 34429769 hsa-mir-27b Carcinoma, Squamous Cell, Cutaneous Moreover, the inhibitory effect of miR-27b-3p on the migratory and invasive abilities of CSCC cells was abolished by MMP-13 overexpression. +circulation_biomarker_diagnosis_up 34429765 hsa-mir-130b Stomach Neoplasms All these results suggested that circulating miR-130b and blood routine parameters might be potential biomarkers, and combinations of measurements of these biomarkers may improve the GC, EGC and Pre diagnostic accuracy. +other 34429762 hsa-mir-15a Carcinoma, Non-Small-Cell Lung Circular RNA SLC26A4 regulates the maturation of microRNA-15a in non-small cell lung cancer cells. +target gene 34429758 hsa-mir-19a Ovarian Neoplasms GATA6-AS1 inhibits ovarian cancer cell proliferation and migratory and invasive abilities by sponging miR-19a-5p and upregulating TET2. +lncRNA target 34429400 hsa-mir-338 Esophageal Squamous Cell Carcinoma 3p was found to directly target SRY-box transcription factor 4 (SOX4) in ESCC cells. +transcription factor target 34429120 hsa-mir-499a Prostatic Neoplasms At the same time, we found that miR-499a combined with UBE2V2 inhibited the expression of UBE2V2 in prostate cancer cells. CONCLUSIONS: In conclusion, our results indicate that miR-499a inhibits the proliferation of human prostate cancer cells by targeting UBE2V2, which will provide a potential target for the treatment of prostate cancer. +lncRNA target 34429073 hsa-mir-29 Acute Kidney Injury CONCLUSIONS: LncRNA TUG can promote PTEN expression by competitively binding to miR-29 to promote autophagy and inhibited apoptosis, thus aggravating acute renal injury in I/R-treated rats. +circulation_biomarker_diagnosis_ns 34428771 hsa-mir-24 Metabolic Diseases Therefore, it is particularly important to study the abnormal regulation of circulating miR +circulation_biomarker_diagnosis_ns 34428771 hsa-mir-24 Obesity Therefore, it is particularly important to study the abnormal regulation of circulating miR +genetics_overexpression_promote 34428620 hsa-mir-182 Kidney Failure, Chronic Further research found that overexpressed FOXO3a partially reversed the inhibitory effect of miR-182 on CRF rats. +transcription factor target 34428587 hsa-mir-143 Cardiomyopathies CONCLUSION: METTL3 deficiency contributes to heart regeneration after MI via METTL3-pri-miR(miR-143)-Yap/Ctnnd1 axis. +other 34428251 hsa-mir-1202 Cardiomyopathies However, the role of miRNA-1202 and its mechanism in myocardial fibrosis remain unclear. +transcription factor target 34428251 hsa-mir-1202 Fibrosis However, the role of miRNA-1202 and its mechanism in myocardial fibrosis remain unclear. MiR-1202 targets nNOS for negative regulation of HCFs fibrosis by decreasing cell differentiation, collagen deposition and the activity of the TGF-beta1/Smad2/3 pathway. +other 34428251 hsa-mir-1202 Atrial Fibrillation Recently, miRNA-1202 have been reported to be up-regulated in AF. +genetics_overexpression_promote 34427978 hsa-mir-513a Breast Neoplasms Feedback approaches validated that miR-513a-5p overexpression or KLF6 depletion reversed the inhibitory effects of ZBED3-AS1 upregulation on viability, proliferative capacity, migration, and invasion of BC cells. +other 34427967 hsa-mir-195 Stomach Neoplasms At the post-transcriptional level, LINC00511 sponged miR5p to elevate SOX4 expression in GC cells. +genetics_overexpression_promote 34427876 hsa-mir-142 late onset Parkinson's disease LINC00943 (or KPNA4) overexpression or miR +genetics_overexpression_promote 34427871 hsa-mir-1274a Carcinoma, Non-Small-Cell Lung Functional studies in two NSCLC cell lines have shown that overexpression of miR-1274a could promote cell proliferation, migration, and invasion. +transcription factor target 34427853 hsa-mir-214 psoriasis 1 3p/FOXM1 axis in keratinocytes could be a novel target in the treatment of psoriasis. +other 34427668 hsa-mir-144 Uterine Diseases Implantation of an intrauterine device containing copper implantation can up-regulate the expression of miR3p in endometrial tissue, and therefore, decreases the mRNA and protein expression levels of genes related to endometrial injury and tissue repair, including the MT/NF-kappaB/MMP damage pathway and the THBS-1/TGF-beta/SMAD3 repair pathway. +lncRNA target 34426596 hsa-mir-708 Neoplasms, Second Primary We demonstrate here that miR-708 (i) is the first miRNA shown to be differentially regulated in TEP and ALT cancer cells, (ii) possesses tumor suppressor function, and (iii) deregulates CARF and p21(WAF1)-mediated signaling to limit proliferation in TEP cells. +genetics_overexpression_promote 34426596 hsa-mir-708 Chemical and Drug Induced Liver Injury Its overexpression induced suppression of cell migration, invasion, and angiogenesis in both TEP and ALT cells, although cell proliferation was inhibited only in TEP cells suggesting that ALT cells may have acquired the ability to escape inhibition of cell proliferation by sustained miR-708 overexpression. +genetics_overexpression_promote 34426596 hsa-mir-708 Polydactyly Its overexpression induced suppression of cell migration, invasion, and angiogenesis in both TEP and ALT cells, although cell proliferation was inhibited only in TEP cells suggesting that ALT cells may have acquired the ability to escape inhibition of cell proliferation by sustained miR-708 overexpression. +genetics_overexpression_promote 34426559 hsa-mir-33a Esophageal Squamous Cell Carcinoma The repression of miR-33a-5p by inhibitor or DKK1 overexpression presented the conversed effects on EC cells. +lncRNA target 34426436 hsa-mir-126 Lymphoma, T-Cell, Peripheral 5p expression regulate RhoA-GTPase and inhibit T-cell migration, crucial for AITL pathobiology. +lncRNA target 34426436 hsa-mir-145 Lymphoma, T-Cell, Peripheral 5p expression regulate RhoA-GTPase and inhibit T-cell migration, crucial for AITL pathobiology. +other 34426107 hsa-mir-26b Arthritis Finally, we concluded that the combination therapy modulated miR-26b and miR-20a as well as GSK-3beta/NF-kappaB/NLRP-3 pathway, provided additive anti-inflammatory and anti-oxidant effects and offered an additional hepatoprotective effect as compared to untreated arthritic rats and MTX-treated groups, suggesting its promising role to be used as replacement therapy to MTX in RA. +other 34426107 hsa-mir-20a Arthritis Finally, we concluded that the combination therapy modulated miR-26b and miR-20a as well as GSK-3beta/NF-kappaB/NLRP-3 pathway, provided additive anti-inflammatory and anti-oxidant effects and offered an additional hepatoprotective effect as compared to untreated arthritic rats and MTX-treated groups, suggesting its promising role to be used as replacement therapy to MTX in RA. +lncRNA target 34425536 hsa-mir-503 Reperfusion Injury, Renal Ischemia Given the well established involvement of Wnt/beta-catenin pathway in fibrosis, this study suggested that dysregulations of Wnts and miR5p coordinate in mediating cadmium-induced kidney fibrosis. +genetics_overexpression_promote 34425282 hsa-mir-142 Retinoblastoma 5p-mediated effects on retinoblastoma progression were blocked by MYCN overexpression in retinoblastoma cells. +lncRNA target 34425198 hsa-mir-204 Zika Virus Infection In our current follow-up study, we investigate that WNT2 is downregulated in response to ZIKV E protein in human fetal NSCs and WNT2 is the molecular target of microRNA miR +other 34425168 hsa-mir-222 Pulmonary Fibrosis Our findings indicate that EMT in alveolar epithelial cells may occur before pulmonary fibrosis, and miR-222 may be used as a potential marker for early prediction of pulmonary fibrosis. +transcription factor target 34424910 hsa-mir-10a Melanoma RESULTS: We discovered that miR-10a-5p expression was lower in melanoma cells and high expression of miR-10a-5p suppressed the proliferation, migration and invasion abilities of melanoma cells. +lncRNA target 34424826 hsa-mir-337 Osteosarcoma 3p and mediates the ceRNA network to promote the expression of ZNF652, thus suppresses osteosarcoma proliferation, migration and invasion. +target gene 34424812 hsa-mir-663a Glioma Up-regulation of miR-663a inhibits the cancer stem cell-like properties of glioma via repressing the KDM2A-mediated TGF-β/SMAD signaling pathway. +other 34424807 hsa-mir-363 Breast Neoplasms Taken together, the present study suggested that FOXD3-AS1 sponges miR-363 to upregulate TFF1 expression, leading to PI3K/Akt signaling activation and anti-estrogen resistance in BC cells. +epigenetics 34424481 hsa-mir-152 Cardiomyopathies Our results stand out together DNMT1 methylation regulates miR3p to slow the progression of cardiac fibrosis by inhibiting the Wnt1/beta-catenin pathway. +lncRNA target 34424120 hsa-mir-620 Osteosarcoma Apatinib-enhanced LINC00261 restrained OS via miR-620/PTEN axis, indicating LINC00261 might promote the efficacy of Apatinib on OS. +exosome 34423867 hsa-mir-23a Pain, Inflammatory Bioinformatics was initially performed to predict the inflammatory pain related downstream targets of miR-23a-3p in macrophage-derived extracellular vesicles (EVs). +genetics_knock down_suppress 34423784 hsa-mir-433 Glioma These evidences manifested that knockdown of circ_0008344 exerted the radiosensitivity-promoting effect on glioma via the miR +other 34423778 hsa-mir-146b Inflammation Identification of Mir146b as a potential regulator of macrophage aging provides novel insights into immune dysfunction associated with aging. +other 34423778 hsa-mir-146b Immune System Diseases Identification of Mir146b as a potential regulator of macrophage aging provides novel insights into immune dysfunction associated with aging. +genetics_overexpression_suppress 34423728 hsa-mir-134 Ovarian Neoplasms TRIM44 overexpression could counteract the inhibitory effects of miR +other 34423698 hsa-mir-523 Arthritis, Rheumatoid CONCLUSION: ZNF667-AS1 exerts protective effects during RA development by sponging miR3p and inactivating the JAK/STAT signalling. +genetics_knock down_promote 34423389 hsa-mir-671 Arthritis, Rheumatoid 5p knockdown, or MDM4 augmentation reversed the repressive effect of paeoniflorin on RA-FLS progression. +lncRNA target 34423048 hsa-mir-587 Carcinoma, Hepatocellular lncRNA PANTR1 promotes HCC progression via mediating the miR +transcription factor target 34423038 hsa-mir-210 Breast Neoplasms The expression of miR-210 has a correlation with chemoresistance of breast cancer MCF-7 cells. MiR-210 regulates the JAK-STAT signal transduction pathway by targeting PIAS4, thus exerting an effect on breast cancer chemosensitivity. +exosome 34422980 hsa-mir-204 Pulmonary Fibrosis 5p antagomir were injected into rats to investigate the effect of exosomal miR +other 34422944 hsa-mir-19a Mastitis It was also found that the expression variation of up-regulated expression of miR-320a, miR-19a, and miR-19b as well as down-regulated expression of miR-143, miR-205, and miR-24 reached a significant level on the 5th and 7th day of infection, suggesting that they might play an important biological role in mastitis and provide a direction for the research and development of molecular therapy technology for mastitis. +other 34422944 hsa-mir-205 Mastitis It was also found that the expression variation of up-regulated expression of miR-320a, miR-19a, and miR-19b as well as down-regulated expression of miR-143, miR-205, and miR-24 reached a significant level on the 5th and 7th day of infection, suggesting that they might play an important biological role in mastitis and provide a direction for the research and development of molecular therapy technology for mastitis. +other 34422944 hsa-mir-143 Mastitis It was also found that the expression variation of up-regulated expression of miR-320a, miR-19a, and miR-19b as well as down-regulated expression of miR-143, miR-205, and miR-24 reached a significant level on the 5th and 7th day of infection, suggesting that they might play an important biological role in mastitis and provide a direction for the research and development of molecular therapy technology for mastitis. +other 34422944 hsa-mir-19b Mastitis It was also found that the expression variation of up-regulated expression of miR-320a, miR-19a, and miR-19b as well as down-regulated expression of miR-143, miR-205, and miR-24 reached a significant level on the 5th and 7th day of infection, suggesting that they might play an important biological role in mastitis and provide a direction for the research and development of molecular therapy technology for mastitis. +other 34422944 hsa-mir-20a Mastitis It was also found that the expression variation of up-regulated expression of miR-320a, miR-19a, and miR-19b as well as down-regulated expression of miR-143, miR-205, and miR-24 reached a significant level on the 5th and 7th day of infection, suggesting that they might play an important biological role in mastitis and provide a direction for the research and development of molecular therapy technology for mastitis. +other 34422944 hsa-mir-24 Mastitis It was also found that the expression variation of up-regulated expression of miR-320a, miR-19a, and miR-19b as well as down-regulated expression of miR-143, miR-205, and miR-24 reached a significant level on the 5th and 7th day of infection, suggesting that they might play an important biological role in mastitis and provide a direction for the research and development of molecular therapy technology for mastitis. +genetics_overexpression_suppress 34422922 hsa-mir-200a Myocardial Infarction Subsequent assays, including echocardiography, enzyme-linked immunosorbent assays (ELISAs), hematoxylin-eosin (H&E) staining, hematoxylin-basic fuchsin-picric acid (HBFP) staining, TdT-mediated dUTP nick-end labeling (TUNEL) staining, immunofluorescence staining, quantitative real-time polymerase chain reaction (qRT-PCR), and Western blotting revealed that miR-200a-3p overexpression inhibited cardiomyocyte pyroptosis and alleviated CME-induced myocardial injury by inhibiting the TXNIP/NOD-like receptor family pyrin domain-containing 3 (NLRP3) pathway. +circulation_biomarker_diagnosis_up 34422901 hsa-mir-128 Diabetic Retinopathy Conclusion: CircFTO promotes angiogenesis and impairs the blood-retinal barrier in vitro and in vivo by binding with miR3p to upregulate TXNIP in DR. +circulation_biomarker_diagnosis_ns 34422806 hsa-mir-484 Carcinoma, Hepatocellular TMEM220-AS1, which was detected primarily in the cytoplasm, functioned as an miRNA sponge to bind miR-484 and promote the level of membrane-associated guanylate kinase, WW, and PDZ domain containing 1 (MAGI1), thereby curbing the malignant phenotypes of HCC cells. In conclusion, low levels of TMEM220-AS1 promote proliferation and metastasis through the miR-484/MAGI1 axis in HCC. +genetics_knock down_promote 34422671 hsa-mir-381 Colorectal Neoplasms 3p suppression reversed the inhibitory actions of LINC01569 knockdown on the expression of RAP2A and CRC progression. +lncRNA target 34422645 hsa-mir-143 Glioma miR-143 inhibition increased HIF1A protein levels, promoted glioma cell invasion and DNA synthesis. Altogether a regulatory axis consisting of OR7E156P, miR-143, and HIF1A, was identified which is deregulated in glioma, and the process of the OR7E156P/miR-143/HIF1A axis modulating glioma cell invasion through ZEB1 and HUVEC tube formation through VEGF was demonstrated. +circulation_biomarker_diagnosis_ns 34422636 hsa-mir-195 Stomach Neoplasms Plasma exosomal miR-195-5p and miR-211-5p may become potential biomarkers for GC diagnosis, and may be useful in predicting tumor phenotype. +circulation_biomarker_diagnosis_ns 34422636 hsa-mir-211 Stomach Neoplasms Plasma exosomal miR-195-5p and miR-211-5p may become potential biomarkers for GC diagnosis, and may be useful in predicting tumor phenotype. +genetics_knock down_promote 34422217 hsa-mir-12119 Multiple Myeloma After knockdown of MSTRG.29039.1 in MM cell lines, the expression of OSMR was decreased, and the expression of hsa-miR-12119 was upregulated which can also promote cell apoptosis and inhibit proliferation. Then, we knocked down hsa-miR-12119 and MSTRG.29039.1, we found that apoptosis of MM cells was reduced, and cell proliferation was increased compared with just knocking down hsa-miR-12119. +genetics_GWAS 34422215 hsa-mir-23a Acute Lung Injury Additional findings demonstrated that the miR-23a-5p agomir exacerbated LPS-induced ALI via activating apoptosis signal-regulating kinase 1 (ASK1), and that pharmacological or genetic inhibition of ASK1 significantly repressed the deleterious effects of the miR-23a-5p agomir. +transcription factor target 34422048 hsa-mir-605 Colonic Neoplasms It was found that KIF3B was a target of KIF3B; decreased KIF3B could reverse the effects of miR +genetics_knock down_suppress 34421997 hsa-mir-485 Osteosarcoma Circ_0084582 knockdown decreased OS growth in vivo partly by the miR +circulation_biomarker_diagnosis_up 34421993 hsa-mir-29 Breast Neoplasms Frequencies of MEG3 rs7158663 GA/AA genotype and A allele were significantly higher in BC patients compared to the controls results showed that serum MEG3 levels were significantly lower, according to the presence of the A allele in different study groups while the expression of miR-182 and miRNA 29 were significantly elevated. MEG3, miR-182, and miRNA-29 are key genes involved in the development of BC, are considered as a novel potential non-invasive diagnostic biomarker for BC. +circulation_biomarker_diagnosis_up 34421993 hsa-mir-182 Breast Neoplasms Frequencies of MEG3 rs7158663 GA/AA genotype and A allele were significantly higher in BC patients compared to the controls results showed that serum MEG3 levels were significantly lower, according to the presence of the A allele in different study groups while the expression of miR-182 and miRNA 29 were significantly elevated. MEG3, miR-182, and miRNA-29 are key genes involved in the development of BC, are considered as a novel potential non-invasive diagnostic biomarker for BC. +lncRNA target 34421987 hsa-mir-124 Thyroid Carcinoma, Anaplastic 3p/ROR1 axis potentially acted as a potential target for the diagnosis of ATC. +genetics_overexpression_suppress 34421982 hsa-mir-125a Colonic Neoplasms Results: TNK2 was overexpressed in colon cancer cell lines, and it was found to directly bind to miR-125a-3p, which was downregulated in these cell lines. +transcription factor target 34421906 hsa-mir-130a Liver Cirrhosis In this study, we investigated the biological functions of miR-130a-3p on the liver fibrosis of schistosomiasis in vivo and in vitro. Our findings suggested that miR-130a-3p might represent as the potential candidate biomarker and therapeutic target for the prognosis identification and treatment of schistosomiasis liver fibrosis. +genetics_overexpression_promote 34421892 hsa-mir-223 Blood Group Incompatibility overexpressing immature (im)DCs. +circRNA target 34421353 hsa-mir-125a Breast Neoplasms These findings indicate that circBCBM1 is involved in breast cancer brain metastasis via circBCBM1/miR-125a/BRD4 axis. +lncRNA target 34420942 hsa-mir-223 Diabetes Mellitus, Type 2 CONCLUSIONS: It can be concluded that long-term moderate-intensity aerobic training might be effective for reducing the occurrence of atherothrombotic events leading to premature death in T2DM patients through the modulation of miRNA-223, P2RY12 receptor expression, and platelet function. +transcription factor target 34420810 hsa-mir-197 Diabetic Retinopathy 3p in PDR patients may play roles in pathophysiology of PDR, the target mRNAs of which significantly enriched in VEGF and TGF-beta signaling pathways. +transcription factor target 34420810 hsa-mir-24 Diabetic Retinopathy 3p in PDR patients may play roles in pathophysiology of PDR, the target mRNAs of which significantly enriched in VEGF and TGF-beta signaling pathways. +transcription factor target 34420810 hsa-mir-184 Diabetic Retinopathy 3p in PDR patients may play roles in pathophysiology of PDR, the target mRNAs of which significantly enriched in VEGF and TGF-beta signaling pathways. +transcription factor target 34420141 hsa-mir-27a Glioma MiR-27a-5p was highly expressed in in patients with glioma, which was associated with poor prognosis, while shFOSL1-inhibited miR-27a-5p expression enhanced the sensitivity of glioma stem cells to radiotherapy. Silent FOSL1 strengthened the radiosensitivity of glioma by down-regulating miR-27a-5p. +other 34420031 hsa-mir-346 Colorectal Neoplasms On the whole, SOX2-induced circ_0026628 sponged miR-346 and recruited FUS protein to augment SP1, triggering the downstream Wnt/beta-catenin pathway to facilitate CRC progression. +circRNA target 34419960 hsa-mir-136 Hepatitis B Circ_0027089 functioned as an oncogene to promote the development of HBV-related HCC by regulating NACC1 via competitively targeting miR +circRNA target 34419960 hsa-mir-136 Carcinoma, Hepatocellular Circ_0027089 functioned as an oncogene to promote the development of HBV-related HCC by regulating NACC1 via competitively targeting miR +target gene 34419497 hsa-mir-26a Colorectal Neoplasms miR-26a enhances colorectal cancer cell growth by targeting RREB1 deacetylation to activate AKT-mediated glycolysis. +other 34419445 hsa-mir-495 Retinoblastoma Our study highlights the importance of bioinformatic analysis in identifying potential markers and mechanisms associated with the malignant transformation of RB, and provides evidence to suggest that PCDHB5 and the ceRNA regulatory network of MALAT1/miR3p/BUB1 are involved in the progression of RB. +circulation_biomarker_diagnosis_up 34419170 hsa-mir-335 Depression Compared with the healthy controls, 2 miRNAs in the plasma exosomes of patients with TRD showed significant differences in expression, among which has-miR +circulation_biomarker_diagnosis_up 34419170 hsa-mir-1292 Depression Compared with the healthy controls, 2 miRNAs in the plasma exosomes of patients with TRD showed significant differences in expression, among which has-miR +circRNA target 34419070 hsa-mir-1294 Carcinoma, Pancreatic Ductal CONCLUSION: CircEYA3 promotes the progression of PDAC through the miR-1294/c-Myc signalling axis, and circEYA3 may be an efficient molecular therapeutic target in PDAC. +lncRNA target 34419065 hsa-mir-26b Breast Neoplasms In summary, METTL3 promoted tumorigenesis of BC via the MALAT1/miR-26b/HMGA2 axis. +genetics_knock down_suppress 34419049 hsa-mir-152 Carcinoma, Endometrioid Loss/gain-of-function experiments certified the impacts of OIP5-AS1 and miR +other 34418898 hsa-mir-155 Multiple Sclerosis The purpose of this study was to investigate the effect of an eight-week combined exercise training (aerobic and resistance) on the expression of inflammatory factors, including, human beta-defensin-2 (hBD-2), cathelicidin (LL-37), TLR-4, miR-23b, miR-155, and miR-326 in women with relapsing and remitting multiple sclerosis (RRMS), which has not been investigated yet. +other 34418898 hsa-mir-23b Multiple Sclerosis The purpose of this study was to investigate the effect of an eight-week combined exercise training (aerobic and resistance) on the expression of inflammatory factors, including, human beta-defensin-2 (hBD-2), cathelicidin (LL-37), TLR-4, miR-23b, miR-155, and miR-326 in women with relapsing and remitting multiple sclerosis (RRMS), which has not been investigated yet. +other 34418898 hsa-mir-326 Multiple Sclerosis The purpose of this study was to investigate the effect of an eight-week combined exercise training (aerobic and resistance) on the expression of inflammatory factors, including, human beta-defensin-2 (hBD-2), cathelicidin (LL-37), TLR-4, miR-23b, miR-155, and miR-326 in women with relapsing and remitting multiple sclerosis (RRMS), which has not been investigated yet. +circulation_biomarker_diagnosis_ns 34418889 hsa-mir-206 Mouth Neoplasms Serum miR-206 might be an effective indicator for early detection of oral cancer. +circRNA target 34418850 hsa-mir-29b Cardiomegaly Consequently, the data demonstrated that circRNA_0001859 promoted the process of cardiac hypertrophy through suppressing miR-29b-3p leading to enhance Ctnnb1 level, and activated downstream pathway molecules LEF1/IGF-2R. +other 34418770 hsa-mir-18a Glioblastoma This study revealed that six differentially expressed angio-miRs (miR-15b, miR-18a-5p, miR-23a-3p, miR-92a-3p, miR-130a-5p, miR-200b-3p) may play important roles in GBM tumorigenesis and invasion, and all respond to melatonin therapy. +other 34418770 hsa-mir-92a Glioblastoma This study revealed that six differentially expressed angio-miRs (miR-15b, miR-18a-5p, miR-23a-3p, miR-92a-3p, miR-130a-5p, miR-200b-3p) may play important roles in GBM tumorigenesis and invasion, and all respond to melatonin therapy. +other 34418770 hsa-mir-15b Glioblastoma This study revealed that six differentially expressed angio-miRs (miR-15b, miR-18a-5p, miR-23a-3p, miR-92a-3p, miR-130a-5p, miR-200b-3p) may play important roles in GBM tumorigenesis and invasion, and all respond to melatonin therapy. +other 34418770 hsa-mir-200b Glioblastoma This study revealed that six differentially expressed angio-miRs (miR-15b, miR-18a-5p, miR-23a-3p, miR-92a-3p, miR-130a-5p, miR-200b-3p) may play important roles in GBM tumorigenesis and invasion, and all respond to melatonin therapy. +other 34418770 hsa-mir-23a Glioblastoma This study revealed that six differentially expressed angio-miRs (miR-15b, miR-18a-5p, miR-23a-3p, miR-92a-3p, miR-130a-5p, miR-200b-3p) may play important roles in GBM tumorigenesis and invasion, and all respond to melatonin therapy. +other 34418506 hsa-mir-10a Depressive Disorder, Major In conclusion, these results indicate the involvement of miR-374b and miR-10a in the biological mechanisms and therapeutic response of MDD, and provide new insights for exploring miRNAs as potential biomarkers for MDD. +other 34418506 hsa-mir-374b Depressive Disorder, Major In conclusion, these results indicate the involvement of miR-374b and miR-10a in the biological mechanisms and therapeutic response of MDD, and provide new insights for exploring miRNAs as potential biomarkers for MDD. +other 34418493 hsa-mir-559 Abortion, Habitual Results showed differential expression of miRNAs implyingmiR-16 and miR-559 as potential biomarkers of RSA in infected women. +other 34418493 hsa-mir-16 Abortion, Habitual Results showed differential expression of miRNAs implyingmiR-16 and miR-559 as potential biomarkers of RSA in infected women. +other 34418490 hsa-mir-497 Arthritis, Rheumatoid Our preliminary results showed that the CDKN2B-AS1/MIR497/TXNIP axis might regulate macrophages of rheumatoid arthritis patients. Compared to cells from healthy donors, cells from rheumatoid arthritis patients expressed higher levels of CD40 and CD80 and lower levels of CD16, CD163, CD206, and CD200R after polarization, they also expressed higher CDKN2B-AS1, lower MIR497, and higher TXNIP. +transcription factor target 34418417 hsa-mir-375 Carcinoma, Brown-Pearce The miR-375 expression decreased the luciferase activity dose-dependently when co-transfected with the AjBAG2 3'-UTR-luciferase reporter containing the miR-375 target site in epithelioma papulosum cyprini (EPC) cells. +transcription factor target 34418417 hsa-mir-375 Pneumonia, Mycoplasma The miR-375 expression decreased the luciferase activity dose-dependently when co-transfected with the AjBAG2 3'-UTR-luciferase reporter containing the miR-375 target site in epithelioma papulosum cyprini (EPC) cells. +other 34417924 hsa-mir-140 Stomach Neoplasms LncRNA CCAT1 Upregulates ATG5 to Enhance Autophagy and Promote Gastric Cancer Development by Absorbing miR-140-3p. +other 34417456 hsa-mir-205 Prostatic Neoplasms SQLE expression is controlled by micro-RNA 205 (miR-205), which is significantly downregulated in advanced PCa. +other 34417328 hsa-mir-263b Sensation Disorders "Fifth, miR-263b null mutants show reduced ""touch-response"" behavior and a compromised response to sound, both characteristic of larval sensory deficits." +lncRNA target 34416910 hsa-mir-600 Carcinoma, Pancreatic Ductal targeted gene NACC1, which facilitates the autophagy response of PDAC cells for adaptation of proliferation via Akt/mTOR pathway. +circulation_biomarker_diagnosis_ns 34416903 hsa-mir-92a Diabetes, Gestational We identified a set of proteins in skeletal muscle biopsies from women with GDM associated with JAK-STAT signaling which could be targeted by the miRNA-92a-3p within circulating EVs. We suggest that miRNA-92a-3p within EVs might be a protected mechanism to increase skeletal muscle insulin sensitivity in GDM. +target gene 34416900 hsa-let-7 Ovarian Neoplasms Long non-coding RNA NEAT1 facilitates the growth, migration, and invasion of ovarian cancer cells via the let-7 g/MEST/ATGL axis. +genetics_overexpression_promote 34416888 hsa-mir-638 Breast Neoplasms Functionally, the viability, migration, and invasion of the breast cancer cells were suppressed by miR-638 overexpression. +lncRNA target 34416339 hsa-mir-582 Colorectal Neoplasms 5p/FOXO1 axis, providing a potential biomarker and therapeutic target for CRC management. +transcription factor target 34416282 hsa-mir-5189 Venous Thrombosis 3p could inhibit apoptosis and promote thrombus organization in DVT possibly via Notch signaling pathway. +other 34415727 hsa-mir-29b-1 Alzheimer Disease The purpose of this study was to investigate whether miR-29a/b1 affected the expression of beta-secrete enzymes (BACE1) in the process of amyloid beta-protein (Abeta) deposition caused by aluminum exposure. In aluminum-exposed groups, the expression of miR-29a and miR-29b1 decreased, while the expression of amyloid protein Abeta1-42 and BACE1 increased. +other 34415727 hsa-mir-29a Alzheimer Disease The purpose of this study was to investigate whether miR-29a/b1 affected the expression of beta-secrete enzymes (BACE1) in the process of amyloid beta-protein (Abeta) deposition caused by aluminum exposure. In aluminum-exposed groups, the expression of miR-29a and miR-29b1 decreased, while the expression of amyloid protein Abeta1-42 and BACE1 increased. +genetics_overexpression_suppress 34415232 hsa-mir-624 Esophageal Squamous Cell Carcinoma The chemotherapy-sensitive cell line KYSE150 and chemotherapy-resistant cell line KYSE410 were transfected with an overexpression plasmid or shRNA to study the effect of miR-624/ARRDC3/YAP/HIF1alpha axis on ESCC cell resistance to CIS and PT. +transcription factor target 34415065 hsa-mir-599 Breast Neoplasms Hsa-miR-599 combined with BRD4 inhibited breast cancer progression through targeting Jagged1/Notch1 pathway. +lncRNA target 34414857 hsa-mir-421 Neurotoxicity Syndromes Moreover, it was identified that miR-421 was a target of ZFAS1, and ZFAS1 regulated the bupivacaine-induced neurotoxicity via miR-421. In conclusion, our results demonstrated that ZFAS1 alleviated bupivacaine-induced neurotoxicity through the miR-421/ZNF564 axis, suggesting a new strategy for the amelioration of bupivacaine-induced neurotoxicity. +genetics_knock down_suppress 34414852 hsa-mir-29 Cicatrix, Hypertrophic In conclusion, NEAT1 knockdown protected against hypertrophic scarring by modulating the miR3p/FRS2 axis, which is a viable target in scar treatment. +genetics_overexpression_promote 34414664 hsa-mir-1 Carcinoma, Ovarian Epithelial Overexpression of GAS5 or inhibition of miR +lncRNA target 34414458 hsa-mir-6884 Ovarian Neoplasms Notably, silencing of RHPN1AS1 functionally reversed the oncogenic effect induced by the miR68845p inhibitor, while the miR68845p inhibitor markedly restored the inhibition of ovarian carcinogenesis modulated by silencing TOP2A in ovarian cancer. +lncRNA target 34414457 hsa-mir-15a Colonic Neoplasms The present study demonstrated that hsamiR15a5p alleviated the proliferation, migration and invasion of colon cancer by targeting the CCND1 gene, which represents a potential molecular target for the diagnosis and treatment of colon cancer. +lncRNA target 34414456 hsa-mir-17 Endometrial Hyperplasia In conclusion, the present study demonstrated that miR175p inhibited the phenotypic modulation VSMCs stimulated by PDGFBB by downregulating HOXB13, indicating that these factors may be potential therapeutic targets for intimal hyperplasia. +lncRNA target 34414454 hsa-mir-28 COVID-19 The findings of the present study suggested that miR283p inhibits ADAM17dependent ACE2 ectodomain shedding in 293T cells treated with the Sprotein of SARSCoV2, which suggested the potential therapeutic role of miR283p mimic in the prevention and treatment of patients with SARSCoV2. +lncRNA target 34414449 hsa-mir-1276 Breast Neoplasms Mechanistic investigations showed that circOMA1 promoted the progression of BC by sponging microRNA (miR)1276 and upregulating sirtuin 4 (SIRT4) expression. In conclusion, circOMA1 may act as an oncogenic circRNA in BC via regulation of the miR1276/SIRT4 axis. +circRNA target 34414414 hsa-mir-485 Thyroid Cancer, Papillary CONCLUSION: Our results discovered the functional network of hsa_circ_0023990 in dedifferentiated TC development by facilitating cell proliferation and glycolysis via miR5p/FOXM1 axis, implying that hsa_circ_0023990 might be a potential therapeutic target for the dedifferentiated TC treatment. +lncRNA target 34414282 hsa-mir-219 Spinal Cord Injuries In conclusion, XIST silencing promoted microglial cell viability and repressed apoptosis and inflammation by sponging miR +lncRNA target 34414175 hsa-mir-675 Leukemia, Myelogenous, Chronic, BCR-ABL Positive The newly identified LNC000093 served as a competitive endogenous RNA for miR5p and reversed the imatinib resistance in CML cells through regulating RUNX1 expression. +lncRNA target 34414106 hsa-mir-185 Colonic Neoplasms Results showed that inhibiting miR-185 expression in the COAD cell line significantly restored the expression of ARID1A. +other 34413954 hsa-mir-21 Metabolic Diseases We demonstrate the approach on the pre-miR-21 stem-loop, which is of significant interest in oncology and metabolic diseases. +exosome 34413928 hsa-mir-25 Lymphoma, T-Cell, Peripheral PTL seems to be related to the decreased exosomal miR +circRNA target 34413915 hsa-mir-338 Carcinoma, Non-Small-Cell Lung 3p inhibitors reversed the suppressor ability of circ_0005909 silence on NSCLC behaviors. +genetics_overexpression_promote 34413821 hsa-mir-26a Intervertebral Disc Degeneration Overexpression of miR-26a-5p promoted ECM synthesis in degenerative NPCs. In conclusion, lncRNA GAS5 sponged miR-26a-5p to upregulate PTEN and inhibit the PI3K/Akt pathway, thus inhibiting ECM synthesis of degenerative NPCs. +circulation_biomarker_diagnosis_down 34413820 hsa-mir-124 Basal Ganglia Hemorrhage 3p was downregulated in the serum of basal ganglia ICH patients and LPS-induced microglia, and miR +other 34413720 hsa-mir-130a Osteochondritis Dissecans Last but not least, we also demonstrated that reducing miR-130a-3p expression partially rescued neuronal morphological changes after OGD in vitro. +lncRNA target 34413652 hsa-mir-1826 Prostatic Neoplasms CONCLUSION: In summary, the low expression of miR-1826 may promote the progression of PC, and the low expression of miR-1826 is also associated with a poor prognosis in PC patients. +genetics_overexpression_suppress 34413269 hsa-mir-224 Osteoarthritis Following prediction analysis of circRNA and miRNA targets, dual-luciferase reporter and silencing/overexpression assays suggested that a regulatory network composed of hsa_circ_0134111, miR +target gene 34413167 hsa-mir-24 Carcinoma, Hepatocellular Additionally, miR3p was proven to be an upstream suppressor of CBS in HCC. +lncRNA target 34412616 hsa-mir-214 Colorectal Neoplasms Finally, PD-L1 was confirmed as important target for miR-214 in CRC. CONCLUSION: In conclusion, our study reveals that a novel axis circEIF3K/miR-214/PD-L1 mediates hypoxia-induced CRC progression via CAF, providing the rationale for developing new targeted therapeutics to treat CRC. +lncRNA target 34411602 hsa-mir-129 Eye Infections, Fungal 5p is a novel small molecule that regulates autophagy by targeting Atg14, indicating that it may be a proinflammatory and therapeutic target for fungal keratitis. +other 34411594 hsa-mir-21 Ovarian Diseases Polycystic ovary syndrome (PCOS) patients have increased miR-21 levels in their sera, granulosa cells, and follicular fluid, and this mi-RNA plays a role in the pathophysiology and follicular dysfunction of PCOS patients. +other 34411594 hsa-mir-21 Polycystic Ovary Syndrome Polycystic ovary syndrome (PCOS) patients have increased miR-21 levels in their sera, granulosa cells, and follicular fluid, and this mi-RNA plays a role in the pathophysiology and follicular dysfunction of PCOS patients. +other 34410972 hsa-mir-92b Colorectal Neoplasms CONCLUSION: We have successfully confirmed miR-92b-3p to be up-regulated in tumor tissue of mCRC patients with good response to bevacizumab/FOLFOX therapy. +lncRNA target 34410682 hsa-mir-17 Sepsis CONCLUSION: CircTLK1 sponged miR5p to aggravate mtDNA oxidative damage, mitochondrial dysfunction and cardiomyocyte apoptosis via activating PARP1/HMGB1 axis during sepsis, indicating that circTLK1 may be a putative therapeutic target for septic cardiomyopathy. +exosome 34410623 hsa-mir-627 Non-alcoholic Fatty Liver Disease In conclusion, these data demonstrate that HUC-MSCs-derived exosomal miR +circulation_biomarker_diagnosis_ns 34410579 hsa-mir-223 Atherosclerosis CONCLUSIONS: Taken together, these data suggest that plasma levels of miR +circulation_biomarker_diagnosis_ns 34410579 hsa-mir-223 Carotid Stenosis CONCLUSIONS: Taken together, these data suggest that plasma levels of miR +other 34410499 hsa-mir-5196 Stroke 5p/MMP2 regulatory axes were identified by enrichment analysis as important networks during the progression of CV-A16 infection. +other 34410499 hsa-mir-6780b Stroke 5p/MMP2 regulatory axes were identified by enrichment analysis as important networks during the progression of CV-A16 infection. +other 34410499 hsa-mir-942 Cardiovascular Diseases 5p/MMP2 regulatory axes were identified by enrichment analysis as important networks during the progression of CV-A16 infection. +other 34410499 hsa-mir-942 Stroke 5p/MMP2 regulatory axes were identified by enrichment analysis as important networks during the progression of CV-A16 infection. +other 34410499 hsa-mir-5196 Cardiovascular Diseases 5p/MMP2 regulatory axes were identified by enrichment analysis as important networks during the progression of CV-A16 infection. +other 34410499 hsa-mir-6780b Cardiovascular Diseases 5p/MMP2 regulatory axes were identified by enrichment analysis as important networks during the progression of CV-A16 infection. +lncRNA target 34410163 hsa-mir-142 Colorectal Neoplasms 3p/X-linked inhibitor of apoptosis axis. +lncRNA target 34409981 hsa-mir-1271 Alzheimer Disease Reportedly, two non-canonical Receptor Tyrosine Kinases (RTKs), ALK and RYK, both targets of the same micro RNA miR-1271, exhibit significant and consistent functional down-regulation in post-mortem AD and T2D tissues. +lncRNA target 34409981 hsa-mir-1271 Diabetes Mellitus, Type 2 Reportedly, two non-canonical Receptor Tyrosine Kinases (RTKs), ALK and RYK, both targets of the same micro RNA miR-1271, exhibit significant and consistent functional down-regulation in post-mortem AD and T2D tissues. +other 34409922 hsa-mir-675 Liver Neoplasms EGR1 and miR-675 were highly expressed, whereas sestrin 3 (SESN3) was poorly expressed in LC tissues and cells. miR-675 upregulation promoted the malignance of LC cells, but further upregulation of SESN3 reduced invasiveness of cells. +lncRNA target 34409897 hsa-mir-30 Pancreatic Carcinoma 5p/FSCN1 ceRNA crosstalk, in regulating pancreatic carcinogenesis and provided that inhibition of circ_0099999 might have therapeutic benefits in pancreatic cancer. +genetics_overexpression_promote 34409798 hsa-mir-17 Squamous Cell Carcinoma of Head and Neck 5p or silencing ACOX1 could reverse the effects of circ_0005379 overexpression on the proliferation, apoptosis, migration, and invasion of OSCC cell lines. +circulation_biomarker_diagnosis_ns 34409736 hsa-mir-4496 Carcinoma, Hepatocellular Mechanistic investigations found that CCAT2 involved in HCC by regulating miR-4496/Atg5 in cytoplasm. +other 34409560 hsa-mir-137 Medulloblastoma This study can conclude that miR-137 may be used as a prognostic biomarker of MB. +genetics_knock down_promote 34409524 hsa-mir-149 Stomach Neoplasms 5p inhibitor or LDHA overexpression could reverse the suppression effect of circ-DONSON knockdown on GC progression. +transcription factor target 34409072 hsa-mir-494 Cardiovascular Diseases Hsa-miR3p may serve as a potential therapeutic target for EH and AF patients in the future. +other 34409031 hsa-mir-543 Carcinoma, Hepatocellular Mechanistically, CRNDE enhanced the stability of ATG4B mRNA by sequestrating miR-543, leading to the elevation of ATG4B and autophagy in HCC cells. +other 34408781 hsa-mir-143 Heart Failure The process is regulated by LncRNA-MiR143HG/miR-143, which may be one of its important mechanisms for the treatment of chronic heart failure. +genetics_overexpression_promote 34408781 hsa-mir-143 Drug-Related Side Effects and Adverse Reactions This research cultured H9C2 cardiomyocytes and divided them into the normal control group, LncRNA-MiR143HG overexpression group, LncRNA-MiR143HG silence group, Adriamycin (ADR) group, ADR medicated serum group, ADR LncRNA-MiR143HG overexpression medicated serogroup, and ADR LncRNA-MiR143HG silence medicated serogroup. +lncRNA target 34408494 hsa-mir-148a Colonic Neoplasms miR-148a-3p played the similar effect of si-SERPINE1 that suppressed the COAD progression. +other 34408477 hsa-mir-222 Carcinoma, Hepatocellular The top ten hub genes including EZH2, CCNB1, E2F1, PBK, CHAF1A, ESR1, RRM2, CCNE1, MCM4, and ATAD2 showed good diagnostic power under the ROC curve; and 2 lncRNAs (LINC00261, LINC00482), 3 miRNAs (hsa-miR-93, hsa-miR-221, hsa-miR-222), and 2 mRNAs (EGR2, LPCAT1) were found to be associated with the overall survival of AFP-negative patients. +other 34408477 hsa-mir-93 Carcinoma, Hepatocellular The top ten hub genes including EZH2, CCNB1, E2F1, PBK, CHAF1A, ESR1, RRM2, CCNE1, MCM4, and ATAD2 showed good diagnostic power under the ROC curve; and 2 lncRNAs (LINC00261, LINC00482), 3 miRNAs (hsa-miR-93, hsa-miR-221, hsa-miR-222), and 2 mRNAs (EGR2, LPCAT1) were found to be associated with the overall survival of AFP-negative patients. +other 34408477 hsa-mir-221 Carcinoma, Hepatocellular The top ten hub genes including EZH2, CCNB1, E2F1, PBK, CHAF1A, ESR1, RRM2, CCNE1, MCM4, and ATAD2 showed good diagnostic power under the ROC curve; and 2 lncRNAs (LINC00261, LINC00482), 3 miRNAs (hsa-miR-93, hsa-miR-221, hsa-miR-222), and 2 mRNAs (EGR2, LPCAT1) were found to be associated with the overall survival of AFP-negative patients. +target gene 34408438 hsa-mir-224 Lung Neoplasms Long Non-Coding RNA TRG-AS1 Promoted Proliferation and Invasion of Lung Cancer Cells Through the miR-224-5p/SMAD4 Axis. +exosome 34408418 hsa-mir-610 Endometriosis EMs-pMphi-exo shuttled lncRNA CHL1-AS1 to promote eESC proliferation, migration, and invasion and inhibit apoptosis by downregulating miR-610 and upregulating MDM2. CONCLUSION: The results demonstrate that exosomal lncRNA CHL1-AS1 promotes the proliferation, migration, and invasion of eESCs and inhibits their apoptosis by downregulating miR-610 and upregulating MDM2, which might be a potential therapeutic target for EMs. +lncRNA target 34408135 hsa-mir-200a Colorectal Neoplasms Visceral adipose-derived factors promote vasculogenesis and the onset of metastatic dissemination by activation of STAT3, which inhibits miR-200a and enhances ZEB2 expression, effectively reprogramming CRC cells into a highly metastatic phenotype. +lncRNA target 34407854 hsa-mir-1 Developmental Dysplasia of the Hip In a previous study, high-throughput miRNA sequencing of tissue samples from an animal model of DDH showed a low level of miR +genetics_overexpression_promote 34407841 hsa-mir-342 Osteosarcoma 3p on the DXR resistance of OS cells also could be reversed by FBN1 overexpression. +lncRNA target 34407684 hsa-mir-424 Acute Kidney Injury CONCLUSIONS: CASC9 alleviates LPS-induced AKI in vivo and in vitro, and CASC9 directly targets miR5p and further promotes the expression of TXNIP. +lncRNA target 34407675 hsa-mir-106b Rhinitis, Allergic Then transfected SNHG16 shRNA alone or together with miR-106b-5p antagomir into the AR cell model, we found that silencing the expression of SNHG16 down-regulated the expression of LIF and inhibited the activity of the JAK1/STAT3 pathway, cell apoptosis, and inflammation. +lncRNA target 34407056 hsa-mir-3171 Uterine Cervical Neoplasms Further, mechanistically investigation revealed that ALOX12-AS1 could interact with AGO2 and sponge miR-3171, thereby antagonizing its' repression of tumor suppressor phosphatase and tensin homolog expression in cervical cancer cell. +lncRNA target 34407055 hsa-mir-195 Carcinoma, Hepatocellular Taken together, our data provide strong evidence that HMGA1 promotes HCC and is negatively regulated by the tumor-suppressor, miR +circRNA target 34407051 hsa-mir-519 Esophageal Squamous Cell Carcinoma Hsa_circ_0014879 silencing enhanced the radiosensitivity of ESCC via regulating the miR +genetics_knock down_promote 34407050 hsa-mir-502 Carcinoma, Renal Cell Circ_0005875 knockdown suppressed RCC progression by regulating miR +genetics_overexpression_promote 34407049 hsa-mir-377 Osteosarcoma Furthermore, CPEB1 overexpression could overturn the suppressive impacts of miR +genetics_knock down_promote 34407047 hsa-mir-338 Uterine Cervical Neoplasms Additionally, the loss-of-functional experiments implied that knockdown of circASAP1 impeded proliferation, migration, and invasion while induced apoptosis and cell cycle arrest in cervical cancer cells along with repressed tumor growth in vivo through regulation of miR +genetics_knock down_promote 34406744 hsa-mir-21 Ovarian Neoplasms It was further tested in live human ovarian cancer (SKOV3) and noncancerous (HEK 293T) cells to exemplify in situ PA activation based on differences in endogenous miR-21 regulation (p = 0.0002). +other 34406553 hsa-mir-590 Hypertrophy 5p modulates myocardium hypertrophy and myocyte apoptosis in HF by downregulating RTN4. +other 34406553 hsa-mir-590 Heart Failure 5p modulates myocardium hypertrophy and myocyte apoptosis in HF by downregulating RTN4. +lncRNA target 34406548 hsa-mir-378 Neuralgia miR-378 acts as an inhibitor in the progression of neuropathic pain via targeting EZH2; the miR-378/EZH2 axis may be a novel target for the diagnosis and therapy of neuropathic pain in clinical treatment. +genetics_overexpression_promote 34406448 hsa-mir-10a Endometrial Neoplasms Transwell assay analysis showed that circ-ATAD1 overexpression totally reversed the enhancing effects of miR-10a on EC cell invasion and migration. +circulation_biomarker_diagnosis_ns 34405969 hsa-mir-9a Carcinoma, Hepatocellular The Kaplan-Meier method was applied to analyze three-year survival, Cox univariate regression was used to analyze the risk factors for recurrence of cirrhotic portal hypertension, and the receiver operating characteristic curve (ROC) was used to evaluate the diagnostic value of serum miR-9a-5p, total bilirubin (TBIL) and platelet (PLT) levels in patients with recurrence. +circulation_biomarker_diagnosis_ns 34405969 hsa-mir-9a Hypertension, Portal The Kaplan-Meier method was applied to analyze three-year survival, Cox univariate regression was used to analyze the risk factors for recurrence of cirrhotic portal hypertension, and the receiver operating characteristic curve (ROC) was used to evaluate the diagnostic value of serum miR-9a-5p, total bilirubin (TBIL) and platelet (PLT) levels in patients with recurrence. +circRNA target 34405943 hsa-mir-30 Carcinoma, Non-Small-Cell Lung In conclusion, our study revealed that silencing of circ_0000517 improved the progression of NSCLC through regulating miR5p/YY1 axis. +circulation_biomarker_diagnosis_ns 34405820 hsa-mir-224 Carcinoma, Hepatocellular RESULTS: It was found miR-224 was elevated in both tissue and serum of HCC patients. +lncRNA target 34405716 hsa-mir-128 Chronic Constipation In conclusion, our study demonstrated that miR-128 regulated the p38alpha/M-CSF signaling pathway to promote chronic inflammatory responses and changes in the immune microenvironment of the colon, thereby offering potential insights into the pathogenesis of CC and therapeutic targets for its treatment.NEW & NOTEWORTHY In this study, we constructed a murine model and identified a novel signaling mechanism involved in the chronic constipation progression. Our findings on the role of miR-128/p38alpha/M-CSF axis provide new insights into the treatment of chronic constipation. +lncRNA target 34405537 hsa-mir-17 Colorectal Neoplasms Our results demonstrated that NBPF4 downregulated EZH2 and stabilized itself by binding to ZFP36, thus escaping from inhibition by miR3p, which allowed mitigation of CRC through inhibition of ETFA. +exosome 34405380 hsa-mir-34a Colorectal Neoplasms Tumor-derived exosomes encapsulating miR-34a promote apoptosis and inhibit migration and tumor progression of colorectal cancer cells under in vitro condition. +other 34405027 hsa-mir-338 Carcinoma, Ovarian Epithelial 3p could serve as prognosis biomarkers for epithelial ovarian cancer. +genetics_overexpression_promote 34405022 hsa-mir-101 Carcinoma, Pancreatic Ductal Further study showed that miRNA-101 level was decreased in PDAC tissues and cells, which could be responsible for DNA-PKcs overexpression and DNA-PKcs mediated oncogenic actions in PDAC cells. +genetics_knock down_promote 34404391 hsa-mir-183 Uterine Cervical Neoplasms 5p overexpression in suppressing cervical cancer development and angiogenesis. +lncRNA target 34403779 hsa-mir-2467 Carcinoma, Non-Small-Cell Lung Presently, LINNC01224 expression was elevated and miR-2467 expression was down-regulated in NSCLC, compared with standard control. To sum up, LINC01224 can promote tumor progression and CDDP resistance in NSCLC via sponging miR-2467, suggesting a promising therapeutic target for better diagnosis and prognosis of NSCLC patients. +genetics_GWAS 34403773 hsa-mir-137 Alcoholism CONCLUSION Our study suggests that MIR137HG genetic variants are associated with the alcohol-induced ONFH susceptibility in a Chinese male population, which may give scientific evidence for exploring molecular mechanisms of the alcohol-induced ONFH. +genetics_GWAS 34403773 hsa-mir-137 Femur Head Necrosis CONCLUSION Our study suggests that MIR137HG genetic variants are associated with the alcohol-induced ONFH susceptibility in a Chinese male population, which may give scientific evidence for exploring molecular mechanisms of the alcohol-induced ONFH. +other 34403754 hsa-mir-29b-1 Aicardi-Goutieres syndrome 5 These novel findings provide evidence of a pathogenic anti-osteogenic role for miR-29b5p and other miRNAs in age-related defects in osteogenesis and bone regeneration. +epigenetics 34403663 hsa-mir-141 Meningitis, Bacterial DNMT1 was involved in the methylation of miR-141 promoter in BM. +circRNA target 34403662 hsa-mir-212 Alzheimer Disease induced apoptosis, inflammation, and oxidative stress via miR +lncRNA target 34403535 hsa-mir-369 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: FOXD1-AS1 elevates FOXD1 expression to promote OSCC malignant phenotypes through miR3p and ADAR. +genetics_overexpression_promote 34403532 hsa-mir-22 Breast Neoplasms 3p or overexpressing ERBB3. +genetics_overexpression_promote 34403518 hsa-mir-34a Arthritis, Rheumatoid Finally, we showed restoration of miR-34a-5p in TUG1-overexpressing FLSs-RA successfully overcame the TUG1-promoted glucose metabolism and apoptosis resistance via targeting LDHA. +other 34403363 hsa-mir-150 Heart Failure However, mechanisms that regulate cell-specific miR-150 expression and function in HF are unknown. +genetics_GWAS 34403295 hsa-mir-146a Behcet Syndrome BACKGROUND A meta-analysis was performed by summarizing relevant researches to evaluate the relationship between miRNA-146a gene polymorphism rs2910164 and Behcet's disease (BD). CONCLUSION In conclusion, this meta-analysis indicates that miRNA-146a gene polymorphism rs2910164 G allele confers BD susceptibility, especially in Caucasians. +lncRNA target 34403009 hsa-mir-1277 Coronary Artery Disease LINC01123 is highly expressed in CAS patients, and promotes cell proliferation and migration via regulating miR +genetics_overexpression_promote 34402705 hsa-mir-20b Pancreatitis Overexpression of miR-20b-5p restrained inflammation and apoptosis in Cer-LPS treated pancreatic acinar cells. +genetics_knock down_promote 34402683 hsa-mir-542 Breast Neoplasms circ_RPPH1 knockdown or miR +other 34401471 hsa-mir-140 Urinary Bladder Neoplasms Annexin A8 regulated by lncRNA-TUG1/miR-140-3p axis promotes bladder cancer progression and metastasis. +circulation_biomarker_diagnosis_up 34401317 hsa-mir-20 Leukemia, Myelogenous, Chronic, BCR-ABL Positive We analysed the plasma miR +genetics_knock down_promote 34400892 hsa-mir-508 Cholesteatoma, Middle Ear Gain and loss of functions of miR +circulation_biomarker_diagnosis_ns 34400887 hsa-mir-452 Diabetes Mellitus, Type 2 MiR-34a-5p and miR5p: The Novel Regulators of Pancreatic Endocrine Dysfunction in Diabetic Zucker Rats? Objective: The pancreatic endocrinal system dominates the regulation of blood glucose levels in vivo, and the dysfunction of pancreatic endocrine -cells is a major cause of the occurrence and development of Type 2 diabetes (T2D). +circulation_biomarker_diagnosis_ns 34400887 hsa-mir-34a Diabetes Mellitus, Type 2 MiR-34a-5p and miR5p: The Novel Regulators of Pancreatic Endocrine Dysfunction in Diabetic Zucker Rats? Objective: The pancreatic endocrinal system dominates the regulation of blood glucose levels in vivo, and the dysfunction of pancreatic endocrine -cells is a major cause of the occurrence and development of Type 2 diabetes (T2D). +other 34400675 hsa-mir-181c Hyperemia Our results demonstrated a ceRNA network consisting of lncRNA-DLEU2, miR-181c-5p and NCAPG, which played an important role in hyperoxia-induced apoptosis of vascular endothelial injury. +genetics_overexpression_suppress 34400241 hsa-mir-132 Alzheimer Disease Overexpressed FOXA1 rescued the effect of elevated miR-132 in AD rats with sevo treatment. +genetics_knock down_promote 34399990 hsa-mir-619 Colorectal Neoplasms Studies on gain-of-function and loss-of-function further testified that knockdown of LINC00882 or up-regulation of miR +genetics_knock down_promote 34399848 hsa-mir-193a Uterine Cervical Neoplasms Gain- and loss-of functional assays of FBXL19-AS1 and miR-193a-5p were performed in CC cell lines in vitro or in vivo. +circulation_biomarker_prognosis_ns 34399782 hsa-mir-543 Carcinoma, Non-Small-Cell Lung RESULTS: LncRNA MEG3 was low in peripheral blood and tissues, while miR-543 was high (P < 0.05); both had good diagnostic values for NSCLC (P < 0.05). +other 34399167 hsa-mir-21 Breast Neoplasms Herein, we developed a novel kind of electrochemical microRNA biosensor based on two-dimensional nanomaterial of antimonene nano-flakes (AMNFs) and carbon quantum dots (CQDs) which were used as substrating to cadmium ion (Cd(2+)) for specific detection of breast cancer-relevant biomarker-microRNA-21. +other 34399097 hsa-mir-7 Spinal Cord Injuries These findings suggest that miR-7 could be developed as a potential treatment for SCI in human. +other 34398996 hsa-let-7g beta-Thalassemia Further, the results also indicate toward a critical role of let7 miRNAs in the pathogenesis of pediatric beta-thalassemia, which needs to be investigated further. +genetics_knock down_promote 34398060 hsa-mir-486 Muscular Atrophy RESULTS: Age-related loss of miR-486 expression was improved, skeletal muscle atrophy and apoptosis were downregulated, and mitochondrial activity and autophagy were upregulated in the adult-MICT group. CONCLUSIONS: Compared with presarcopenia-MICT rats, adult-MICT rats experienced greater beneficial effects regarding ameliorated age-related alterations in muscle miRNA expression profile, skeletal muscle atrophy, apoptosis, and mitochondria and autophagy dysfunction, which is potentially associated with the increased miR-486 expression and concomitant targeting of the PTEN/Akt signaling pathway. +lncRNA target 34398060 hsa-mir-486 Sarcopenia CONCLUSIONS: Compared with presarcopenia-MICT rats, adult-MICT rats experienced greater beneficial effects regarding ameliorated age-related alterations in muscle miRNA expression profile, skeletal muscle atrophy, apoptosis, and mitochondria and autophagy dysfunction, which is potentially associated with the increased miR-486 expression and concomitant targeting of the PTEN/Akt signaling pathway. +genetics_knock down_promote 34398060 hsa-mir-486 Death RESULTS: Age-related loss of miR-486 expression was improved, skeletal muscle atrophy and apoptosis were downregulated, and mitochondrial activity and autophagy were upregulated in the adult-MICT group. CONCLUSIONS: Compared with presarcopenia-MICT rats, adult-MICT rats experienced greater beneficial effects regarding ameliorated age-related alterations in muscle miRNA expression profile, skeletal muscle atrophy, apoptosis, and mitochondria and autophagy dysfunction, which is potentially associated with the increased miR-486 expression and concomitant targeting of the PTEN/Akt signaling pathway. +genetics_knock down_promote 34398060 hsa-mir-486 Congenital amegakaryocytic thrombocytopenia RESULTS: Age-related loss of miR-486 expression was improved, skeletal muscle atrophy and apoptosis were downregulated, and mitochondrial activity and autophagy were upregulated in the adult-MICT group. CONCLUSIONS: Compared with presarcopenia-MICT rats, adult-MICT rats experienced greater beneficial effects regarding ameliorated age-related alterations in muscle miRNA expression profile, skeletal muscle atrophy, apoptosis, and mitochondria and autophagy dysfunction, which is potentially associated with the increased miR-486 expression and concomitant targeting of the PTEN/Akt signaling pathway. +lncRNA target 34398060 hsa-mir-486 Mitochondrial Diseases CONCLUSIONS: Compared with presarcopenia-MICT rats, adult-MICT rats experienced greater beneficial effects regarding ameliorated age-related alterations in muscle miRNA expression profile, skeletal muscle atrophy, apoptosis, and mitochondria and autophagy dysfunction, which is potentially associated with the increased miR-486 expression and concomitant targeting of the PTEN/Akt signaling pathway. +lncRNA target 34398060 hsa-mir-486 Leukopenia CONCLUSIONS: Compared with presarcopenia-MICT rats, adult-MICT rats experienced greater beneficial effects regarding ameliorated age-related alterations in muscle miRNA expression profile, skeletal muscle atrophy, apoptosis, and mitochondria and autophagy dysfunction, which is potentially associated with the increased miR-486 expression and concomitant targeting of the PTEN/Akt signaling pathway. +circulation_biomarker_diagnosis_ns 34398018 hsa-mir-499 Myocardial Infarction, Acute It also indicated a sensitivity [0.84 (95% CI: 0.70--0.92)] and specificity [0.97 (95% CI: 0.87--0.99)] of miR-499 for AMI. CONCLUSIONS: Circulating miR-1, miR-133, miR-208, and miR-499 showed diagnostic values in AMI. +lncRNA target 34397934 hsa-mir-145 Ovarian Neoplasms Through bioinformatics analysis, we further explored the mechanism of miRNA-145 in ovarian cancer and related pathways. +circulation_biomarker_diagnosis_up 34396445 hsa-mir-10a Osteoporosis The relative expression levels of GAS5 and miR10a3p in the serum samples of patients with osteoporosis, as well as the relative expression levels of GAS5, microRNA (miR)10a3p and vascular endothelial growth factor A (VEGFA) mRNA in osteoblasts, were detected by reverse transcriptionquantitative PCR. GAS5 was significantly downregulated and miR10a3p was upregulated in patients with osteoporosis. +other 34396444 hsa-mir-17 Carcinoma, Non-Small-Cell Lung In summary, CuB reduced the proliferation of GR PC9 cells by modulating the miR175p/STAT3 axis, and may represent a promising potential novel strategy for the reversal of GR. +transcription factor target 34396443 hsa-mir-125a Cardiovascular Diseases The current study verified that miR125a5p and miR7 may be used as feasible therapeutic targets for cardiovascular diseases. +transcription factor target 34396443 hsa-mir-7 Vascular Diseases The current study verified that miR125a5p and miR7 may be used as feasible therapeutic targets for cardiovascular diseases. +transcription factor target 34396443 hsa-mir-125a Vascular Diseases The current study verified that miR125a5p and miR7 may be used as feasible therapeutic targets for cardiovascular diseases. +transcription factor target 34396443 hsa-mir-7 Cardiovascular Diseases The current study verified that miR125a5p and miR7 may be used as feasible therapeutic targets for cardiovascular diseases. +genetics_knock down_promote 34396434 hsa-mir-532 Colorectal Neoplasms In conclusion, overexpression of circNRIP1 promoted the progression of CRC, while circNRIP1 silencing sensitized CRC cells to 5FU via sponging miR5323p. +genetics_knock down_suppress 34396433 hsa-mir-4306 Colorectal Neoplasms The inhibitory effects of FoxD2AS1 silencing on CRC progression were reversed by miR4306 knockdown. +transcription factor target 34396430 hsa-mir-25 Intervertebral Disc Degeneration Overall, the results of the present study demonstrated that miR25 could promote the proliferation and inhibit the apoptosis of NPCs via targeting SUMO2, suggesting that miR25 may be a potential target in the treatment of IVDD. +genetics_knock down_promote 34396427 hsa-mir-8063 Colorectal Neoplasms These results suggest that as a tumor suppressor, miR8063 is involved in regulating the selfrenewal of CRCSCs, where loss of miR8063 expression weakens its inhibition on hnRNPAB, which leads to the activation of Wnt/betacatenin signaling to promote the selfrenewal of CRCSCs. +other 34395911 hsa-mir-185 Hepatitis C This article was designed to explore the effects and mechanisms of miR5p on the replication of hepatitis C virus (HCV). +lncRNA target 34395629 hsa-mir-339 Laryngeal Neoplasms 5p can inhibit the autophagy to decrease the cisplatin resistance of laryngeal carcinoma via targeting TAK1. +transcription factor target 34395626 hsa-mir-483 Glioblastoma We also identified several CD163-associated kinase, miRNA, and transcription factor targets in GBM, including LCK, miR-483, and ELF1. +other 34395419 hsa-mir-223 Prostatic Neoplasms CircGNG4 Promotes the Progression of Prostate Cancer by Sponging miR-223 to Enhance EYA3/c-myc Expression. +genetics_overexpression_promote 34395415 hsa-mir-1 Carcinoma, Hepatocellular What is more, ORC6 overexpression counteracted the biological functions of miR +other 34395263 hsa-mir-5197 Colorectal Neoplasms A Genome-Scale CRISPR Knock-Out Screen Identifies MicroRNA-5197-5p as a Promising Radiosensitive Biomarker in Colorectal Cancer. +target gene 34395239 hsa-mir-124 Colorectal Neoplasms The critical role of the c-Myc/NEAT1 axis in mediating CRC response to PDT treatment via the miR-124/iASPP/p53 feedback loop was conclusively demonstrated. +lncRNA target 34395238 hsa-mir-638 Multiple Myeloma Thus, this study aimed to further characterize the regulatory function of circ-PTK2 on cell malignant activities and its target microRNA-638 (miR-638) as well as downstream MEK/ERK, WNT/beta-catenin signaling pathways in MM. In conclusion, circ-PTK2 promotes cell proliferation, migration, suppresses cell apoptosis via miR-638 mediated MEK&ERK and WNT&beta-catenin signaling pathways in MM. +lncRNA target 34394903 hsa-mir-28 Leukemia, Myeloid, Acute 3p/CCND2 through MALAT1, resulting in Ara-C resistance in AML. +lncRNA target 34394829 hsa-mir-623 Substance Abuse, Intravenous Here, we find that microRNA-623 (miR-623) is downregulated in IVDD and its expression is regulated by hypoxia-inducible factor-1alpha (HIF-1alpha) under oxidative stress conditions. Thus, on elucidating the expression and functional mechanisms of miR-623, our study suggests that miR-623 can be a valuable therapeutic target for treating oxidative stress-induced IVDD. +other 34394340 hsa-mir-145 Neuralgia 5p, Atf3, Cacna2d1, Gal, and Ctss related to NP were validated by real-time PCR. +genetics_overexpression_promote 34394002 hsa-mir-344 Diabetes Mellitus In cholesterol-stimulated and PA-induced diabetic beta-cell model, cholesterol-caused and PA-caused suppression on cell viability, increase in intracellular cholesterol level, decrease in GSIS, and increase in lip droplet deposition were dramatically attenuated via the overexpression of miR +other 34394002 hsa-mir-344 Pancreatic Diseases Insulin receptor downstream MPAK/ERK signaling was involved in the protection of miR5p against cholesterol-induced pancreatic beta-cell dysfunction. +transcription factor target 34393805 hsa-mir-130a Fibrous Dysplasia, Polyostotic The miR-130a-3p/TGF-betaRII axis could suppress the differentiation of lung fibroblasts via the TGF-beta1/Smad signaling pathway, thereby reducing the process of PF. +lncRNA target 34393509 hsa-mir-513c Thyroid Neoplasms CONCLUSION: The TNRC6C-AS1/miR-513c-5p/LPAR5 axis is a novel signaling pathway that modulates THCA progression and may be a potential target for cancer therapy. +other 34392742 hsa-mir-27a Essential Hypertension 3p and hsa_circ_0025088/hsa-miR-27a-3p axis involving RAAS were potential EH pathways. +other 34392742 hsa-mir-483 Essential Hypertension 3p and hsa_circ_0025088/hsa-miR-27a-3p axis involving RAAS were potential EH pathways. +transcription factor target 34392240 hsa-mir-124 Parkinson Disease 3p may have pivotal roles in improving isoflurane-induced learning and memory impairment via targeting STAT3 and inhibiting neuroinflammation. +transcription factor target 34392240 hsa-mir-124 Neurogenic Inflammation 3p may have pivotal roles in improving isoflurane-induced learning and memory impairment via targeting STAT3 and inhibiting neuroinflammation. +lncRNA target 34391823 hsa-mir-148a Ischemic Stroke To summarize, this study demonstrated that lncRNA HOTAIR absorbed miR-148a-3p and up-regulated KLF6 expression through ceRNA mechanism, and inhibited STAT3 pathway, promoted apoptosis and inflammation, and aggravated neurological injury post-IS. +circulation_biomarker_diagnosis_ns 34391435 hsa-mir-184 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: The expression levels of miR-184 and miR5p derived from exosomes in the peripheral blood of NSCLC patients could be used as biomarkers to indicate osimertinib resistance. +circulation_biomarker_diagnosis_ns 34391435 hsa-mir-3913 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: The expression levels of miR-184 and miR5p derived from exosomes in the peripheral blood of NSCLC patients could be used as biomarkers to indicate osimertinib resistance. +other 34391433 hsa-mir-140 Urinary Bladder Neoplasms LINC01410 leads the migration, invasion and EMT of bladder cancer cells by modulating miR-4319 / Snail1. +other 34390638 hsa-mir-9 Atrial Fibrillation OBJECTIVES: The aim of this study is to assess micro-RNAs miR-142 and miR-39 as potential biomarkers for drug-monitoring of rivaroxaban among elderly patients with atrial fibrillation. +other 34390638 hsa-mir-142 Atrial Fibrillation OBJECTIVES: The aim of this study is to assess micro-RNAs miR-142 and miR-39 as potential biomarkers for drug-monitoring of rivaroxaban among elderly patients with atrial fibrillation. +other 34390467 hsa-mir-122 Non-alcoholic Fatty Liver Disease 5p may play an important role in NAFLD. +exosome 34390377 hsa-mir-217 Urinary Bladder Neoplasms CONCLUSION: These findings suggested that hBSC-derived exosomal miR-217 may act as oncogene in bladder cancer cells, and that Hippo-YAP signaling pathway maybe the target for miR-217 in the bladder cancer cell lines. +lncRNA target 34390329 hsa-mir-17 Prostatic Neoplasms These results suggested that targeting circSMARCA5-miR-181b-5p-TIMP3 and circSMARCA5-miR3p-TIMP3 axis might be a novel therapeutic strategy for prostate cancer. +lncRNA target 34390329 hsa-mir-181b Prostatic Neoplasms These results suggested that targeting circSMARCA5-miR-181b-5p-TIMP3 and circSMARCA5-miR3p-TIMP3 axis might be a novel therapeutic strategy for prostate cancer. +genetics_knock down_promote 34390174 hsa-mir-142 Colorectal Neoplasms 3p inhibition weakened the impact of circ_0087862 knockdown on CRC cells. +other 34390171 hsa-mir-490 Hamartoma Syndrome, Multiple Moreover, we also found a correlation between downregulated miRNAs in CSs/CDCs and patient age (eg miR-490) and an inverse correlation among miRNAs upregulated in CSs/CDCs (eg miR-31). +other 34390171 hsa-mir-1 Hamartoma Syndrome, Multiple Moreover, we also found a correlation between downregulated miRNAs in CSs/CDCs and patient age (eg miR-490) and an inverse correlation among miRNAs upregulated in CSs/CDCs (eg miR-31). +other 34390171 hsa-mir-490 Sexually Transmitted Diseases Moreover, we also found a correlation between downregulated miRNAs in CSs/CDCs and patient age (eg miR-490) and an inverse correlation among miRNAs upregulated in CSs/CDCs (eg miR-31). +other 34390171 hsa-mir-1 Sexually Transmitted Diseases Moreover, we also found a correlation between downregulated miRNAs in CSs/CDCs and patient age (eg miR-490) and an inverse correlation among miRNAs upregulated in CSs/CDCs (eg miR-31). +lncRNA target 34389916 hsa-mir-200c Triple Negative Breast Neoplasms PURPOSE: To investigate the effectiveness of targeted ECO/miR-200c in modulating tumor microenvironment and treating triple negative breast cancer (TNBC) using non-invasive magnetic resonance molecular imaging (MRMI) of extradomain B fibronectin (EDB-FN) with a targeted MRI contrast agent. +lncRNA target 34389797 hsa-mir-214 Atrial Fibrillation Taken together, the key findings of our study suggest that XIST may blunt myocardial pyroptosis by absorbing miR3p to promote Arl2 expression, providing encouraging insight into XIST-based targeted therapy for AF. +other 34389752 hsa-mir-126 Acute Kidney Injury Comparison of urinary microRNA profiles from AKI patients with controls detected significant injury-specific increases in miR-21, miR-126 and miR-141 (p < 0.05) and decreases in miR-192 (p < 0.001) and miR-204 (p < 0.05). +other 34389752 hsa-mir-21 Acute Kidney Injury Comparison of urinary microRNA profiles from AKI patients with controls detected significant injury-specific increases in miR-21, miR-126 and miR-141 (p < 0.05) and decreases in miR-192 (p < 0.001) and miR-204 (p < 0.05). +other 34389752 hsa-mir-192 Acute Kidney Injury Comparison of urinary microRNA profiles from AKI patients with controls detected significant injury-specific increases in miR-21, miR-126 and miR-141 (p < 0.05) and decreases in miR-192 (p < 0.001) and miR-204 (p < 0.05). +other 34389752 hsa-mir-204 Acute Kidney Injury Comparison of urinary microRNA profiles from AKI patients with controls detected significant injury-specific increases in miR-21, miR-126 and miR-141 (p < 0.05) and decreases in miR-192 (p < 0.001) and miR-204 (p < 0.05). +other 34389752 hsa-mir-141 Acute Kidney Injury Comparison of urinary microRNA profiles from AKI patients with controls detected significant injury-specific increases in miR-21, miR-126 and miR-141 (p < 0.05) and decreases in miR-192 (p < 0.001) and miR-204 (p < 0.05). +other 34389732 hsa-mir-205 Hyperleptinemia These studies uncover the mechanistic insights how obese/hyperleptinemic state may contribute to poor response to tamoxifen implicating leptin-miR205-Med1 and leptin-Her2-EGFR-Med1 axes, and present bioactive compound honokiol and adipocytokine adiponectin as agents that can block leptin's negative effect on tamoxifen. +other 34389732 hsa-mir-205 Breast Neoplasms These studies uncover the mechanistic insights how obese/hyperleptinemic state may contribute to poor response to tamoxifen implicating leptin-miR205-Med1 and leptin-Her2-EGFR-Med1 axes, and present bioactive compound honokiol and adipocytokine adiponectin as agents that can block leptin's negative effect on tamoxifen. +other 34389732 hsa-mir-205 Obesity These studies uncover the mechanistic insights how obese/hyperleptinemic state may contribute to poor response to tamoxifen implicating leptin-miR205-Med1 and leptin-Her2-EGFR-Med1 axes, and present bioactive compound honokiol and adipocytokine adiponectin as agents that can block leptin's negative effect on tamoxifen. +other 34389032 hsa-mir-155 Kidney Transplant Rejection 5p was a previously reported signature in KTR, whereas the remaining two were novel candidates both for KTR diagnosis and subtyping. +genetics_overexpression_promote 34389030 hsa-mir-27a Squamous Cell Carcinoma of Head and Neck RESULTS: In our study, we found overexpression of HPV E6 upregulated the expression of DGCR8 and miR-27a-3p in HNSCC cells. +genetics_overexpression_promote 34389030 hsa-mir-27a Papillomavirus Infections RESULTS: In our study, we found overexpression of HPV E6 upregulated the expression of DGCR8 and miR-27a-3p in HNSCC cells. +lncRNA target 34389018 hsa-mir-4640 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: Taken together, we demonstrated that down-regulation of OGFRP1 inhibited the progression of NSCLC through miR +lncRNA target 34388692 hsa-mir-205 Stomach Neoplasms 3p as a tumor suppressor gene in gastric cancer (GC). +transcription factor target 34388478 hsa-mir-105 Carcinoma, Hepatocellular Consistently, miR-105 upregulation inhibited the proliferation of HCC cells, while downregulation of miR-105 reversed Propofol-induced HCC cell apoptosis. CONCLUSION: Propofol significantly attenuated HCC tumorigenesis via mediation of miR-105/JAK2/STAT3 axis. +transcription factor target 34388475 hsa-mir-98 Stomach Neoplasms DISCUSSION: All our results proved that OA could promote balance of Treg/Th17 cells in GC by targeting IL-6 with miR +other 34388112 hsa-mir-21 Colorectal Neoplasms 3p and hsa-miR-891a-5p) correlated with the most remarkable prognostic values of CRC patients were selected to establish the risk score model (RSM) by univariate and multivariate COX regression analysis and the survival probability of the low-risk group was longer than that in the high-risk group. +other 34388112 hsa-mir-891a Colorectal Neoplasms 3p and hsa-miR-891a-5p) correlated with the most remarkable prognostic values of CRC patients were selected to establish the risk score model (RSM) by univariate and multivariate COX regression analysis and the survival probability of the low-risk group was longer than that in the high-risk group. +other 34388112 hsa-mir-194 Colorectal Neoplasms 3p and hsa-miR-891a-5p) correlated with the most remarkable prognostic values of CRC patients were selected to establish the risk score model (RSM) by univariate and multivariate COX regression analysis and the survival probability of the low-risk group was longer than that in the high-risk group. +genetics_overexpression_promote 34388111 hsa-mir-221 Osteosarcoma Further, in-vivo tests uncovered that overexpressing miR +other 34387972 hsa-mir-1281 Aortic Aneurysm, Abdominal RESULTS: There was a hyperexpression of miRNA-1281 in patients with AAA and a significant reduction of it after EVAR, from 1.66-fold before EVAR to 0.27 after the procedure (P<0.0001). CONCLUSION: MiRNA-1281 may contribute as a possible marker of EVAR follow-up. +genetics_overexpression_promote 34387848 hsa-mir-143 Uterine Cervical Neoplasms 3p overexpression was also substantiated to inhibit the tumorigenicity of cervical cancer cells in vivo, while CDK1 overexpression counteracted their effect. +genetics_overexpression_promote 34387848 hsa-mir-495 Uterine Cervical Neoplasms 3p overexpression was also substantiated to inhibit the tumorigenicity of cervical cancer cells in vivo, while CDK1 overexpression counteracted their effect. +circRNA target 34387610 hsa-mir-223 Multiple Myeloma 3p/BRD4 pathway, which provided a new potential target for multiple myeloma chemoresistance. +circRNA target 34387609 hsa-mir-338 Nasopharyngeal Carcinoma 3p/SMAD5 axis, providing potential targets for improving the treatment of chemoresistant NPC. +circRNA target 34387608 hsa-mir-646 Carcinoma, Non-Small-Cell Lung Circ-RNF121 and SOX4 were increased, and miR-646 was declined in DDP-resistant NSCLC tissues and cells. Circ-RNF121 silencing could reduce the DDP resistance of NSCLC cells by regulating SOX4 expression via miR-646. +lncRNA target 34387601 hsa-mir-885 Stomach Neoplasms 3p/CHD7 axis, which might be a novel strategy to inhibit gastric cancer progression. +lncRNA target 34387599 hsa-mir-515 Prostatic Neoplasms Thus, we came a conclusion that circFOXM1 contributed to PCa progression via regulating miR5p/ADAM10 axis. +genetics_knock down_suppress 34387598 hsa-mir-873 Breast Neoplasms Circ_0085495 knockdown reduced ADM resistance in ADM-resistant cells through modulating miR +lncRNA target 34387594 hsa-mir-141 Carcinoma, Renal Cell 3p could regulate CCRCC cell proliferation, migration, invasion and apoptosis by targeting NEK6. +genetics_overexpression_promote 34387591 hsa-mir-34c Colorectal Neoplasms In addition, MSI1 was a target of circ_KIAA1199, and the inhibitory effects of miR-34c-5p restoration on CRC cell proliferation, survival, migration and invasion were reversed by MSI1 overexpression. Circ_KIAA1199 functioned as an oncogene to drive the malignant development of CRC by activating MSI1 via competitively targeting miR-34c-5p. +genetics_overexpression_suppress 34387590 hsa-mir-214 Retinoblastoma Overexpression of miR +other 34387138 hsa-mir-635 Triple Negative Breast Neoplasms The study identifies first time the association of hsa-miR-1250, has-miR-1273, and has-miR-635 with the TNBC. +other 34387138 hsa-mir-1250 Triple Negative Breast Neoplasms The study identifies first time the association of hsa-miR-1250, has-miR-1273, and has-miR-635 with the TNBC. +other 34387138 hsa-mir-1273 Triple Negative Breast Neoplasms The study identifies first time the association of hsa-miR-1250, has-miR-1273, and has-miR-635 with the TNBC. +other 34386930 hsa-mir-4458 Carcinoma, Non-Small-Cell Lung The results showed that the expression level of miR-4458 decreased and STAT3 increased in NSCLC tissues and cells. +other 34386667 hsa-mir-204 Glomerulonephritis, IGA However, there was no difference in miR-204 expression between IgAN and non-IgAN chronic kidney disease controls. CONCLUSION: Additional large-scale studies are now needed to validate the additive value of miR-204 in improving risk prediction in IgAN and more broadly in chronic kidney disease. +other 34386496 hsa-mir-21 Osteosarcoma Downregulated lncRNA GAS5 and Upregulated miR-21 Lead to Epithelial-Mesenchymal Transition and Lung Metastasis of Osteosarcomas. +circulation_biomarker_diagnosis_up 34386495 hsa-mir-665 Epidermodysplasia Verruciformis Finally, compared with that of the control group, miR-665 was highly expressed in serum samples in the aging and EVA groups, especially in the EVA groups. Collectively, in the aging and EVA groups, miR-665 expression was negatively correlated with lncRNA GAS5 and SDC1 expression. +lncRNA target 34386494 hsa-mir-196 Liver Neoplasms Further, MAFG-AS1 promotes growth and migration of HCC by upregulating STRN4 through absorbing miR-3196. +genetics_knock down_suppress 34386489 hsa-mir-1205 Prostatic Neoplasms Underexpression of miR-1205 is observed when NED is induced in vitro and inhibition of miR-1205 leads to increased expression of NED markers. However, while FRYL is overexpressed during NED, FRYL knockdown did not reduce NED, therefore revealing that miR-1205 induces NED independently of FRYL. +target gene 34386427 hsa-mir-23a prostate carcinoma The Circular RNA circXPO1 Promotes Tumor Growth via Sponging MicroRNA-23a in Prostate Carcinoma. +genetics_overexpression_promote 34386421 hsa-mir-200b Esophageal Squamous Cell Carcinoma CCAT2 promoted the migration and invasion of ESCC cells in vitro, and tumorigenesis in vivo by upregulating TK1 expression, while overexpression of miR-200b reversed these effects of CCAT2. +circulation_biomarker_diagnosis_down 34386414 hsa-mir-125b Carcinoma, Hepatocellular These findings highlight that circulating exosomal miR-125b might represent a reliable biomarker with diagnostic and therapeutic implications for extrahepatic metastasis from HCC. +lncRNA target 34386303 hsa-mir-204 Diabetes Mellitus CONCLUSION: NEAT1 regulated the development of EMT in DR through miR-204/SOX4 pathway, which could provide reference for clinical prevention and treatment. +genetics_knock down_suppress 34386091 hsa-mir-542 Osteosarcoma lncRNA XLOC_005950 knockout may inhibit the progression of OS via hsa-miR-542-3p-mediated regulation of PFKM expression. +lncRNA target 34386082 hsa-mir-1298 Breast Neoplasms 5p was demonstrated to inhibit the proliferation, adhesion and migration of BC cells and to promote BC cell apoptosis. +genetics_overexpression_promote 34386074 hsa-mir-1303 Carcinoma, Non-Small-Cell Lung In summary, the findings from this study suggested that LINC01272 expression, which was decreased in NSCLC tumor tissues and NSCLC cells, may be used as an independent prognostic biomarker for patients with NSCLC and that its overexpression may suppress NSCLC cell proliferation, migration and invasion by inhibiting miR-1303. +genetics_knock down_promote 34386071 hsa-mir-133a Colorectal Neoplasms Furthermore, AQP1-knockdown induced, while overexpression reversed, the suppressive effects of miR-133a-3p on CRC cells. +other 34386062 hsa-mir-383 Glioma Rescue experiments confirmed that the lnc-NLC1-C/miR-383/PRDX-3 axis was involved in the molecular mechanism of glioma progression. +other 34385927 hsa-mir-449a Gastroparesis, Diabetic Collectively, our data highlight a novel regulatory signaling pathway, the MALAT1/miR-449a/DLL1 axis, in the context of DGP. +lncRNA target 34385891 hsa-mir-20a Stomach Neoplasms Wnt/beta-catenin pathway and EMT in GC cells were suppressed by LOC100505817 through miR-20a-inhibted WT1. In summary, our results provided evidence suggesting that LOC100505817 inhibits GC through LOC100505817-mediated inhibition of Wnt/beta-catenin pathway, that leads to the overall restraining of GC cell proliferation, migration and invasion through miR-20a-reduced WT1. +other 34385599 hsa-mir-486 Ataxia with vitamin E deficiency 5p together (p < 0.01), were associated with ADT response. +other 34385599 hsa-mir-21 Ataxia with vitamin E deficiency 5p together (p < 0.01), were associated with ADT response. +other 34385308 hsa-mir-122 Hepatitis C Hepatitis C virus (HCV) is a positive-sense RNA virus that interacts with a liver-specific microRNA called miR-122. +lncRNA target 34384932 hsa-mir-128 Obesity Our findings reveal that inhibition of miR-128 can be a new potential target for reversing the effects of metabolic disorders of skeletal muscle as observed during many pathophysiological conditions such as obesity and type II diabetes. +lncRNA target 34384932 hsa-mir-128 Diabetes Mellitus, Type 2 Our findings reveal that inhibition of miR-128 can be a new potential target for reversing the effects of metabolic disorders of skeletal muscle as observed during many pathophysiological conditions such as obesity and type II diabetes. +transcription factor target 34384932 hsa-mir-128 Mitochondrial Diseases Also, miR-128 is shown to promote mitochondrial dysfunction by directly targeting NADH Dehydrogenase (Ubiquinone) Fe-S Protein 4 (NDUFS4). +lncRNA target 34384932 hsa-mir-128 Metabolic Diseases Our findings reveal that inhibition of miR-128 can be a new potential target for reversing the effects of metabolic disorders of skeletal muscle as observed during many pathophysiological conditions such as obesity and type II diabetes. +lncRNA target 34384839 hsa-mir-126 Coronary Artery Disease CONCLUSION: LncRNA CDKN2B-AS1 upregulates PTPN7 by absorbing miR5p and inhibits the PI3K-Akt pathway, thus hindering the proliferation and accelerating apoptosis of VSMCs induced by ox-LDL, thus being a therapeutic approach for CAS. +other 34384839 hsa-mir-126 Coronary Disease METHODS: Microarray analyses were performed to screen out the CHD-related lncRNAs (CDKN2B-AS1) and the downstream microRNAs (miR5p). +other 34384839 hsa-mir-126 Inflammation Then pcDNA-CDKN2B-AS1 and/or miR5p mimic were transfected into ox-LDL-treated VSMCs to estimate cell proliferation, apoptosis and inflammation. +exosome 34384713 hsa-mir-25 Carcinoma, Hepatocellular derived exosomes promoted the development of HCC by reducing SIK1 expression and potentiating the Wnt/beta-catenin pathway. +lncRNA target 34384283 hsa-mir-215 Wilms Tumor Moreover, transfection of pcDNA3.1-CRK in G401 and WT-CLS1 cells could partially reverse the inhibitory effect of miR +lncRNA target 34384196 hsa-mir-34 Uterine Cervical Neoplasms The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer. +lncRNA target 34384196 hsa-mir-375 Spherocytosis, Type 1 The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer. +lncRNA target 34384196 hsa-mir-375 Uterine Cervical Neoplasms The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer. +other 34384196 hsa-mir-205 Spherocytosis, Type 1 miR-205 has been shown to have a higher specificity than human papilloma virus testing in predicting the absence of high-grade squamous intraepithelial lesions (HSILs) in exfoliated cell samples. +other 34384196 hsa-mir-205 Squamous Intraepithelial Lesions miR-205 has been shown to have a higher specificity than human papilloma virus testing in predicting the absence of high-grade squamous intraepithelial lesions (HSILs) in exfoliated cell samples. +lncRNA target 34384196 hsa-mir-34 Disease The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer. +lncRNA target 34384196 hsa-mir-34 Spherocytosis, Type 1 The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer. +lncRNA target 34384196 hsa-mir-34 Squamous Intraepithelial Lesions The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer. +lncRNA target 34384196 hsa-mir-29 Disease The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer. +lncRNA target 34384196 hsa-mir-29 Spherocytosis, Type 1 The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer. +lncRNA target 34384196 hsa-mir-203 Squamous Intraepithelial Lesions The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer. +lncRNA target 34384196 hsa-mir-29 Uterine Cervical Neoplasms The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer. +circulation_biomarker_diagnosis_up 34384196 hsa-mir-21 Disease Among the miRNAs, miR-21 is the most prevalent, and it is consistently upregulated progressively from normal cervical to worsening cervical lesion stages in both cell and serum samples. +lncRNA target 34384196 hsa-mir-29 Squamous Intraepithelial Lesions The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer. +lncRNA target 34384196 hsa-mir-203 Disease The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer. +circulation_biomarker_diagnosis_up 34384196 hsa-mir-21 Uterine Cervical Diseases Among the miRNAs, miR-21 is the most prevalent, and it is consistently upregulated progressively from normal cervical to worsening cervical lesion stages in both cell and serum samples. +other 34384196 hsa-mir-205 Papillomavirus Infections miR-205 has been shown to have a higher specificity than human papilloma virus testing in predicting the absence of high-grade squamous intraepithelial lesions (HSILs) in exfoliated cell samples. +lncRNA target 34384196 hsa-mir-375 Squamous Intraepithelial Lesions The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer. +lncRNA target 34384196 hsa-mir-375 Disease The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer. +lncRNA target 34384196 hsa-let-7 Disease The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer. +lncRNA target 34384196 hsa-let-7 Squamous Intraepithelial Lesions The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer. +lncRNA target 34384196 hsa-let-7 Spherocytosis, Type 1 The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer. +lncRNA target 34384196 hsa-let-7 Uterine Cervical Neoplasms The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer. +other 34384196 hsa-mir-205 Disease miR-205 has been shown to have a higher specificity than human papilloma virus testing in predicting the absence of high-grade squamous intraepithelial lesions (HSILs) in exfoliated cell samples. +lncRNA target 34384196 hsa-mir-203 Spherocytosis, Type 1 The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer. +lncRNA target 34384196 hsa-mir-203 Uterine Cervical Neoplasms The tumor suppressor miRNAs miR-34, let-7, miR-203 miR-29, and miR-375 were significantly downregulated in low-grade squamous intraepithelial lesions, HSILs, and cervical cancer. +other 34383804 hsa-mir-29a Rhinitis, Allergic RESULTS: 1 in circleCompared with healthy controls, miR-29a expression was up-regulated and FOS mRNA expression was down-regulated in the nasal tissues from the patients with allergic rhinitis (AR). CONCLUSION: MiR-29a-/FOS axis can be regarded as a potential marker and a new therapy for AR. +lncRNA target 34383714 hsa-mir-186 HIV-Associated Lipodystrophy Syndrome Enhanced miR-20a-3p or depletion of miR-186 and miR5p may downregulate Ltbp2 in HIV, leading to dysregulation in adipose differentiation and inflammation, which could contribute to acquired HIV lipodystrophy and associated metabolic and inflammatory perturbations. +lncRNA target 34383714 hsa-mir-20a HIV-Associated Lipodystrophy Syndrome Enhanced miR-20a-3p or depletion of miR-186 and miR5p may downregulate Ltbp2 in HIV, leading to dysregulation in adipose differentiation and inflammation, which could contribute to acquired HIV lipodystrophy and associated metabolic and inflammatory perturbations. +lncRNA target 34383714 hsa-mir-24 HIV-Associated Lipodystrophy Syndrome Enhanced miR-20a-3p or depletion of miR-186 and miR5p may downregulate Ltbp2 in HIV, leading to dysregulation in adipose differentiation and inflammation, which could contribute to acquired HIV lipodystrophy and associated metabolic and inflammatory perturbations. +lncRNA target 34383404 hsa-mir-20a Urinary Bladder Neoplasms MiR 20a plays an oncogenic role in bladder cancer, which contributes to target LASS2 directly. +other 34383354 hsa-mir-206 Diabetic Retinopathy PPF modulated MALAT1/miR-206/ATG3 axis to protect cardiomyocytes against I/R injury. +exosome 34382916 hsa-mir-527 Ovarian Neoplasms Our study demonstrated that silencing circ_C20orf11 sensitizes ovarian cancer to DDP by promoting miR-527/YWHAZ signaling and EV-mediated macrophage M2 polarization. +circulation_biomarker_diagnosis_up 34382731 hsa-mir-155 Osteoporosis In the present study, we collected serum samples from 10 clinical osteoporosis patients to detect long noncoding RNA-neighboring enhancer of FOXA2 (lncRNA-NEF) and miR-155 expression levels. The level of lncRNA-NEF was downregulated, and miR-155 was upregulated, in serum samples from patients with clinical osteoporosis. +transcription factor target 34382727 hsa-mir-221 Breast Neoplasms Our study not only identified miRNA-221 as a pivotal factor conferring the acquired resistance of HER2-positive breast cancer cells to lapatinib through negatively regulating p27(kip1) expression, but also suggested Src inhibition as a potential strategy to overcome lapatinib resistance. +epigenetics 34382305 hsa-mir-9-1 Nasopharyngeal Carcinoma In NPC cells, hypermethylation regulates miR +lncRNA target 34382070 hsa-mir-126 Endometriosis Our study revealed the METTL3/m6A/miR126 pathway, whose inhibition might contribute to endometriosis development by enhancing cellular migration and invasion. +circulation_biomarker_diagnosis_ns 34381972 hsa-mir-486 Atherosclerosis Lastly, profiling microRNA in BMDM-HG-exo and plasma EVs from diabetic subjects with advanced atherosclerosis converged on miR5p as commonly enriched and recognized in dysregulated hematopoiesis and Abca1 control. +genetics_knock down_promote 34381816 hsa-mir-26a Uveal melanoma The knockout of EZH2 mimicked the tumor inhibition of miR-26a in UM cells, whereas the reintroduction of EZH2 abolished this effect. +other 34381778 hsa-mir-139 Depression CONCLUSION: These results provide important evidence that emodin may be a candidate agent for the treatment of depression and established a key role of miR5p/5-LO in the inflammation of depression. +genetics_knock down_promote 34381772 hsa-mir-645 Colorectal Neoplasms In addition, TGFBR2 was a target of miR-645, and miR-645 inhibition-suppressed CRC cell proliferation, migration/invasion and glycolysis were restored by TGFBR2 knockdown. CircFAM120B inhibited CRC progression partly by mediating the miR-645/TGFBR2 network, which explained the potential mechanism of circFAM120B function in CRC. +lncRNA target 34381729 hsa-mir-503 Stomach Neoplasms METHODS: The bioinformatics analysis was performed to examine the expression status of cancer associated genes in patients with stomach adenocarcinoma (STAD) and predict the targeting sites of miR5p with LncRNA MIR503HG and TUSC3. +lncRNA target 34381729 hsa-mir-224 Stomach Neoplasms CONCLUSIONS: Targeting the LncRNA MIR503HG/miR +other 34381702 hsa-mir-641 Glioma Taken together, the data indicated that COX10-AS1 acts as an oncogene in combination with COX10-AS1/miR-641/E2F6 in glioma, which may be beneficial to the diagnosis and treatment of glioma. +other 34381564 hsa-mir-7 Holoprosencephaly 7 MiR5p is a recently discovered downregulated miRNA in thyroid papillary carcinoma (PTC). +lncRNA target 34381564 hsa-mir-7 Thyroid Cancer, Papillary 5p inhibits thyroid cell proliferation by modulating the MAPK and PI3K signaling pathways which are both necessary for normal thyroid proliferation and play central roles in PTC tumorigenesis. +genetics_knock down_promote 34381502 hsa-mir-146b Carcinoma, Hepatocellular Moreover, miR-146b-5p suppression or CBX6 elevation evidently rescued the suppressed viability, migration, and invasion of HCC cells caused by MIR100HG knockdown. +lncRNA target 34381417 hsa-mir-223 Epilepsy, Temporal Lobe These findings show that miR 223 affects microglial autophagy via ATG16L1 in the KA model of TLE. +transcription factor target 34381349 hsa-mir-339 Parkinson Disease We identified 32 target genes of miR +circulation_biomarker_diagnosis_up 34381349 hsa-mir-96 Parkinson Disease Our goal was to study two serum circulating microRNAs (miR +circulation_biomarker_diagnosis_up 34381349 hsa-mir-96 Multiple System Atrophy Our goal was to study two serum circulating microRNAs (miR +transcription factor target 34381349 hsa-mir-339 Multiple System Atrophy We identified 32 target genes of miR +genetics_overexpression_promote 34381025 hsa-mir-29b Spinal Cord Injuries Inhibition of miR-29b-3p or overexpression of PTEN reversed the repair effect of EVs on SCI. +transcription factor target 34381015 hsa-mir-223 Diabetes Mellitus 3p) through high-throughput sequencing and quantitative real-time PCR analysis, that are remarkably decreased in the elderly and diabetic groups. +transcription factor target 34381015 hsa-mir-7 Diabetes Mellitus 3p) through high-throughput sequencing and quantitative real-time PCR analysis, that are remarkably decreased in the elderly and diabetic groups. +transcription factor target 34381015 hsa-mir-145 Diabetes Mellitus 3p) through high-throughput sequencing and quantitative real-time PCR analysis, that are remarkably decreased in the elderly and diabetic groups. +transcription factor target 34381015 hsa-mir-24 Diabetes Mellitus 3p) through high-throughput sequencing and quantitative real-time PCR analysis, that are remarkably decreased in the elderly and diabetic groups. +circulation_biomarker_diagnosis_down 34380897 hsa-mir-491 Brain Injuries, Traumatic 5p downregulation promotes neovascularization, restores cerebral blood flow, and improves the recovery of neurological function after traumatic brain injury. +lncRNA target 34380584 hsa-mir-93 Thyroid Neoplasms In addition, CCK-8, immunofluorescence, wound-healing and transwell assays were applied to demonstrate that SNHG14 promoted the proliferation, migration and invasion of thyroid tumour cells by targeting miR +circulation_biomarker_prognosis_up 34380511 hsa-mir-92b Breast Neoplasms CONCLUSION: miR-92b-3p expression obviously rises in the serum of BC patients and is closely related to the clinical staging, degree of differentiation, and CA125 in BC, so the detection of this miRNA is of great significance to the diagnosis and prognostic evaluation of BC. +circulation_biomarker_diagnosis_up 34380068 hsa-mir-140 Arthritis, Rheumatoid Our results first demonstrated an increased expression of circulating miR-140 and serum leptin in PsA patients compared to RA, which were identified as potential additional biomarkers to discriminate PsA from RA. +circulation_biomarker_diagnosis_up 34380068 hsa-mir-140 Arthritis, Psoriatic Our results first demonstrated an increased expression of circulating miR-140 and serum leptin in PsA patients compared to RA, which were identified as potential additional biomarkers to discriminate PsA from RA. +exosome 34378676 hsa-mir-21 Esophageal Neoplasms The objective of this study was to investigate the effect of human esophageal fibroblast-derived exosomal miR-21 on cisplatin sensitivity against esophageal squamous EC9706 cells. EC9706 cells were co-cultured indirectly with human esophageal fibroblasts (HEF) or miR-21 mimics transfected-HEF in the transwell system. +genetics_overexpression_suppress 34378327 hsa-mir-149 Squamous Cell Carcinoma of Head and Neck GACAT1 overexpression induced TSCC cell growth and migration via regulating miR-149 expression. +genetics_overexpression_promote 34378285 hsa-mir-134 Breast Neoplasms 5p overexpression could suppress BC tumor growth via targeting ARHGAP1 in vivo. +other 34378214 hsa-mir-135a Asthenozoospermia Low expression of JAK2 mRNA and high expression of miR-135a-5p were related to asthenozoospermia and male infertility. +circulation_biomarker_diagnosis_ns 34378123 hsa-mir-24 Thyroid Cancer, Papillary RESULTS: We identified miR24-3p, miR146a-5p, miR181a-5p and miR382-5p with different expression levels in two different series of 56 and 58 PTC patients as compared with healthy controls. When comparing the expression levels of some PTC-specific exosomal miRNAs with those of the same miRNAs circulating free of any encapsulation, we found a significant correlation for only miR24-3p, suggesting that only select miRNAs are secreted in exosomes. +lncRNA target 34377430 hsa-mir-129 Intervertebral Disc Degeneration 5p relieved IDD via inhibition of the LRG1/p38 MAPK signaling in vivo. +lncRNA target 34377277 hsa-mir-153 Spinal Cord Injuries CONCLUSION: We proved that miR-153 attenuated inflammatory response and oxidative stress induced by SCI by targeting of NEUROD2, indicating a protective role in SCI progression. +other 34377255 hsa-mir-148b Osteosarcoma LncRNA HCG18 promotes cell multiplication and metastasis by miR-148b/ETV5 regulation in osteosarcoma. +transcription factor target 34377252 hsa-mir-1307 Osteoarthritis CONCLUSION: The suppression of miR +target gene 34377249 hsa-mir-136 Triple Negative Breast Neoplasms Transfection with miRNA-136 can significantly inhibit the proliferation of TNBC cells by external transfection, and has little effect on cell apoptosis. +circulation_biomarker_prognosis_up 34377248 hsa-mir-29a Sepsis-Associated Encephalopathy CONCLUSION: miR-29a is closely associated with the development of SAE, and miR-29a in the peripheral blood can be used as a potential biological index to predict whether sepsis is complicated with SAE and indications of a poor prognosis. +exosome 34377236 hsa-mir-200b Femur Head Necrosis Collectively, our results showed that hsa-miR-200b-3p and hsa-miR-206 in urinary exosomes might serve as non-invasive biomarkers for SONFH. +exosome 34377236 hsa-mir-206 Femur Head Necrosis Collectively, our results showed that hsa-miR-200b-3p and hsa-miR-206 in urinary exosomes might serve as non-invasive biomarkers for SONFH. +genetics_overexpression_promote 34377235 hsa-mir-296 Breast Neoplasms 5p inhibition or FOXP4 overexpression restored the malignant properties of circRPPH1-silenced BC cells. +lncRNA target 34377233 hsa-mir-221 Carcinoma, Renal Cell 5p/SOCS1 axis as a tumor suppressor in RCC. +other 34377228 hsa-mir-194 Epidermodysplasia Verruciformis 5p axis in apoptosis induced by EV71 infection, while no association with autophagy was observed. +other 34377051 hsa-mir-217 Esophageal Achalasia Further analysis using qRT-PCR showed significant down-regulation of hsa-miR-217 (p-value = 0.004) in achalasia tissue. +genetics_overexpression_suppress 34377026 hsa-mir-577 Stomach Neoplasms Finally, the results demonstrate the overexpression of miR-577 and the silence of RAB14 could inhibit the effects of circTMCO3 on proliferation, migration and invasion in GC cells. +lncRNA target 34377022 hsa-mir-1324 Stomach Neoplasms CONCLUSION: Propofol exerted anticancer role in GC through regulating circPDSS1/miR-1324/SOX4 axis, indicating that propofol might be an effective therapeutic medicine for GC treatment. +transcription factor target 34377019 hsa-mir-455 pancreatic adenocarcinoma 3p in PAAD tissue was closely connected with poor prognosis, and only 5 target mRNAs were predicted to be increased in PAAD tissue with poor prognosis. +circRNA target 34377018 hsa-mir-1253 Carcinoma, Hepatocellular CONCLUSION: Circ_0072995 exerted tumorigenic roles to enhance HCC progression through activating EIF4A3 by sponging miR-1253. +genetics_overexpression_promote 34376998 hsa-mir-765 Carcinoma, Non-Small-Cell Lung CONCLUSION: The overexpression of miR-765 in NSCLC was associated with TNM stage and poor prognosis of patients. +other 34376644 hsa-mir-942 Carcinoma, Hepatocellular Telocytes promote hepatocellular carcinoma by activating the ERK signaling pathway and miR-942-3p/MMP9 axis. +lncRNA target 34376255 hsa-mir-29c Inflammation CONCLUSIONS: miR-29c-3p has potential as a biomarker for the diagnosis of sepsis, and inhibition of miR-29c-3p expression in animal models reduced sepsis-induced cardiac dysfunction and inflammatory response. +lncRNA target 34376255 hsa-mir-29c Sepsis CONCLUSIONS: miR-29c-3p has potential as a biomarker for the diagnosis of sepsis, and inhibition of miR-29c-3p expression in animal models reduced sepsis-induced cardiac dysfunction and inflammatory response. +other 34375951 hsa-mir-335 Osteoporosis 5p, were significantly higher expressed in osteoporotic patients compared with non-osteoporotic individuals. +exosome 34375914 hsa-mir-885 Transmissible Gastroenteritis Overall, the results indicated that TGEV-ORF3b counteracted NF-kappaB pathway and TNF-alpha via regulating miR +genetics_knock down_promote 34375306 hsa-mir-335 Triple Negative Breast Neoplasms 3p or knockdown of WNT2 removed the promoted effects of lncRNA HAGLR on TNBC development. +tissue_expression_ns 34375168 hsa-mir-380 Spinal Cord Injuries circTYW1 and FGF9 were poorly expressed, whereas miR-380 was highly expressed in the spinal cord tissues of SCI rats. +lncRNA target 34374893 hsa-let-7b Colorectal Neoplasms Moreover, the correlation analysis between LAMTOR5 and LAMTOR5-AS1 revealed a significant association in CRC (p value = 0.0074) which can be partly explained by its predicting act as a mediator with sponging effect on hsa-miR-let-7b-3p and hsa-miR-20a-5p. LAMTOR5-AS5 which is a nearby lncRNA of this gene could play a regulatory impact through its sponging effect on hsa-miR-let-7b-3p and hsa-miR-20a-5p which both have shown a significant impact on overall survival rate in CRC patients in high expression levels. +lncRNA target 34374893 hsa-mir-20a Colorectal Neoplasms Moreover, the correlation analysis between LAMTOR5 and LAMTOR5-AS1 revealed a significant association in CRC (p value = 0.0074) which can be partly explained by its predicting act as a mediator with sponging effect on hsa-miR-let-7b-3p and hsa-miR-20a-5p. LAMTOR5-AS5 which is a nearby lncRNA of this gene could play a regulatory impact through its sponging effect on hsa-miR-let-7b-3p and hsa-miR-20a-5p which both have shown a significant impact on overall survival rate in CRC patients in high expression levels. +other 34374662 hsa-mir-181a Pancreatic Carcinoma In the present study, we show that ANRIL was up-regulated while miR-181a was down-regulated in pancreatic cancer tissues and HMGB1 was highly expressed. +genetics_knock down_promote 34374639 hsa-mir-6736 Breast Neoplasms 3p inhibitor and NRP-1 overexpression could partly reverse the suppressive influence of RP11-70C1.3 knockdown on breast cancer chemoresistance. +genetics_knock down_promote 34374638 hsa-mir-122 Breast Neoplasms Our data concluded that knockdown of CDKN2B-AS1 suppresses the progression of breast cancer by miR +other 34374576 hsa-mir-221 Carcinoma, Hepatocellular miR-221 can be used as a promising prognostic biomarker of hepatocellular carcinoma. +transcription factor target 34374261 hsa-mir-335 Colonic Neoplasms 5p may inhibit the proliferation and promote apoptosis of colon cancer cells by targeting G6PD. +transcription factor target 34374235 hsa-mir-125b Hemangioma Conclusion: miR-125b-5p inhibits the proliferation of human hemangioma endothelial cells and induces apoptosis. +other 34373727 hsa-mir-934 Colorectal Neoplasms miR-934/DDK2 axis regulated colorectal cancer cell proliferation +lncRNA target 34373722 hsa-mir-103a Vascular Calcification Therefore, it was concluded that miR-103a plays a notable role in the transdifferentiation of the VSMCs in high phosphorus-induced calcification by targeting the regulation of RUNX2, and may therefore constitute a new target for the diagnosis and treatment of vascular calcification. +target gene 34373706 hsa-mir-449a Triple Negative Breast Neoplasms MicroRNA-449a inhibits cell proliferation and migration by regulating mutant p53 in MDA-MB-468 cells. +genetics_overexpression_suppress 34373692 hsa-mir-124 Osteosarcoma 3p overexpression, which involved the derepression of sphingosine kinase 1 (SphK1). +genetics_overexpression_promote 34373436 hsa-mir-22 Osteosarcoma To sum up, overexpressed MIR22HG inhibits the viability and proliferation of osteosarcoma cells, which was achieved via regulation of the miR +lncRNA target 34373133 hsa-mir-24 Aortic Aneurysm, Thoracic CONCLUSION: NEAT1 could contribute to the malignant behaviors of TAA cells by targeting miR +genetics_knock down_promote 34372909 hsa-mir-126 Leukemia, Myeloid, Acute Loss of miR-126(high) ECs led to a decreased EC miR-126 supply to LSCs, which then entered the cell cycle and promoted leukemia growth. +genetics_overexpression_promote 34372727 hsa-mir-204 Stomach Neoplasms A rescue assay revealed that knocked-down DSCAM-AS1 hindered GC progression, which was reversed upon miR-204 downregulation or TPT1 overexpression. +genetics_overexpression_promote 34372727 hsa-mir-204 Down Syndrome A rescue assay revealed that knocked-down DSCAM-AS1 hindered GC progression, which was reversed upon miR-204 downregulation or TPT1 overexpression. +exosome 34371055 hsa-mir-125b Prostatic Neoplasms 5p were differentially expressed in mPCa exosomes. +exosome 34371055 hsa-mir-425 Prostatic Neoplasms 5p were differentially expressed in mPCa exosomes. +exosome 34371055 hsa-mir-205 Prostatic Neoplasms 5p were differentially expressed in mPCa exosomes. +exosome 34371055 hsa-mir-148a Prostatic Neoplasms 5p were differentially expressed in mPCa exosomes. +lncRNA target 34370878 hsa-mir-98 Colorectal Neoplasms Additionally, BCAT1 was proved to enhance cell progression as the target of miR +genetics_overexpression_promote 34370715 hsa-mir-138 Melanoma The SIRT7 overexpression and miR +other 34370714 hsa-mir-205 Diabetic Foot 5p negatively regulated angiogenesis and wound healing in patients with diabetic foot. +other 34370714 hsa-mir-195 Diabetic Foot 5p negatively regulated angiogenesis and wound healing in patients with diabetic foot. +exosome 34370713 hsa-mir-326 Esophageal Squamous Cell Carcinoma In general, exosomal LINC01711 promoted the proliferation, migration, and invasion of esophageal cancer cells by up-regulating FSCN1 and down-regulating miR-326, thus improved the occurrence and development of ESCC. +other 34370552 hsa-mir-136 Triple Negative Breast Neoplasms In conclusion, circ-ERBB2 facilitated the Warburg effect and malignancy of TNBC cells by the miR5p/PDK4 pathway, at least in part. +genetics_overexpression_promote 34370360 hsa-mir-26a Cardiomegaly Overexpression of miR-26a-5p by type 9 recombinant adeno-associated virus (rAAV9) reversed the heart hypertrophic manifestations. +other 34370073 hsa-mir-638 Ovarian Neoplasms 5p, and miR-638 molecules might be the noninvasive biomarkers in identifying the ovarian cancer. +other 34370073 hsa-mir-16 Ovarian Neoplasms 5p, and miR-638 molecules might be the noninvasive biomarkers in identifying the ovarian cancer. +other 34370073 hsa-mir-17 Ovarian Neoplasms 5p, and miR-638 molecules might be the noninvasive biomarkers in identifying the ovarian cancer. +genetics_knock down_suppress 34370061 hsa-mir-873 Stomach Neoplasms 3p could attenuate the circRNA_0043691 knockdown on GC cells proliferation, migration, and invasion. +lncRNA target 34369711 hsa-mir-449a Osteosarcoma MiR-449a impeded the viability and proliferation of osteosarcoma cells and controlled the cell cycle through targeting cyclin D1 to reduce pRB phosphorylation. +circRNA target 34369654 hsa-mir-149 Uterine Cervical Neoplasms Circ_0011385 elevates SOX4 expression by targeting miR +other 34369363 hsa-mir-22 Arthritis, Rheumatoid RESULTS: The logistic regression results showed that miR-22 (p=0.0003) and miR-26a (p=0.049) may be the most important molecules distinguishing RA patients and healthy controls. Moreover, the quantity of miR-22 was different between rheumatoid factor (RF)-positive and RF-negative patients (p=0.04). +lncRNA target 34369270 hsa-mir-361 Carcinoma, Squamous Cell, Cutaneous 5p inhibition rescued the suppressing effects of NEAT1 depletion on cell proliferation, invasion as well as Wnt pathway in CSCC. +other 34369267 hsa-mir-1270 Adenocarcinoma of Lung In brief, this study has demonstrated that GLIDR/miR-1270/TCF12 axis plays the crucial role in LUAD, which offers a new insight into researches on molecular mechanism concerning LUAD and provides with a new perspective for LUAD treatment. +lncRNA target 34369259 hsa-mir-448 Myocardial Reperfusion Injury The AK006774/miR-448/bcl-2 signaling axis acts as a key regulator of I/R injury and may be a potential therapeutic or diagnostic target for the treatment of MI. +genetics_overexpression_promote 34369236 hsa-mir-146b Carcinoma, Ovarian Epithelial Finally, our data demonstrated that miR-146b overexpression resulted in a greater suppression of cell migration than STAT3 pathway inhibition alone.These results suggest a complex and heterogeneous role of EGFR in ovarian cancer. +other 34369163 hsa-mir-133a Myocardial Infarction Herein, a near-infrared light (NIR)-initiated PEC biosensor based on NaYF(4):Yb,Tm@NaYF(4)@TiO(2)@CdS (csUCNRs@TiO(2)@CdS) was constructed for sensitive detection of acute myocardial infarction (AMI)-related miRNA-133a in an immobilization-free format coupled with a hybridization chain reaction and a redox circle signal amplification strategy. +lncRNA target 34369082 hsa-mir-196b Huntington Disease Moreover, upregulated DNM3OS decreased the expression of miR-196b-5p by sponging, and GAPDH was a direct target of miR-196b-5p, playing an important pathogenic role in the formation of aggregates in the HD cell model. Our study uncovers a novel DNM3OS/miR-196b-5p/GAPDH pathway involved in the molecular pathogenesis of HD, which may offer a potential therapeutic strategy for HD. +genetics_knock down_promote 34369042 hsa-mir-425 Inflammation 5p overexpression attenuated neuronal apoptosis in the Rot-mediated PD model, TH-positive cell loss, and microglial activation by mitigating inflammation and oxidative stress. +genetics_knock down_promote 34369042 hsa-mir-425 Parkinson Disease 5p overexpression attenuated neuronal apoptosis in the Rot-mediated PD model, TH-positive cell loss, and microglial activation by mitigating inflammation and oxidative stress. +other 34369033 hsa-mir-181a Osteoarthritis SNHG5 and miR-181a-5p expression levels were then detected in cartilage tissues of osteoarthritis patients and C20/A4 cells by quantitative polymerase chain reaction (qPCR). The expression levels of SNHG5 and TGFBR3 were markedly decreased, and miR-181a-5p expression was enhanced in osteoarthritis tissues and chondrocytes treated with IL-1beta. +circRNA target 34368980 hsa-mir-139 Cystitis, Interstitial 5p/MFN2 axis indicating that circTHBS1 might be a potential target for IC treatment. +genetics_GWAS 34368922 hsa-mir-195 Leukemia, Myeloid, Acute RESULTS We found that the expression of miR-195 was the lowest in cytogenetically normal (CN-) AML, and high expression of miR-195 only promoted the prognosis of chemotherapy-only CN-AML patients (EFS: P=0.016; OS: P=0.035). +other 34368874 hsa-mir-28 Colorectal Neoplasms Moreover, the results herein revealed that the expression of miR285p was negatively correlated with that of CDKN2BAS1 in CRC tissue. +transcription factor target 34368871 hsa-mir-296 Colorectal Neoplasms Together, the results of the present study suggested the potential importance of the miR2963p/GRINA axis and highlighted potential novel targets for the management of CRC. +genetics_knock down_promote 34368861 hsa-mir-128 Colorectal Neoplasms Rescue experiments demonstrated that inhibiting miR1283p or upregulating E2F3 offset the effects of SNHG22 knockdown on CRC cells. The present findings support the existence of an interactive regulatory network involving SNHG22, miR1283p and E2F3 in CRC cell lines, indicating that the SNHG22/miR1283p/E2F3 axis may be considered a novel diagnostic and therapeutic target in CRC. +genetics_knock down_promote 34368370 hsa-mir-200c Endometrial Neoplasms Moreover, further study revealed that miR-200c-3p could bind to OIP5-AS1, and the loss function of miR-200c-3p could reverse the elevated OIP5-AS1's inhibitory effect on the progression of EC. +transcription factor target 34368354 hsa-mir-1228 Lung Diseases, Interstitial GO and KEGG analyses suggested that several pathways may contribute the pathogenesis of DM-ILD-MDA5 Ab(+) and DM-nonILD-MSA16(-), while PPI network analysis of hsa-miR-4488 and hsa-miR5p indicated that their predicted target genes, DExD-box helicase 39B and MDM2, may be involved in the mechanisms of DM-ILD-MDA5 Ab(+). +transcription factor target 34368354 hsa-mir-4488 Lung Diseases, Interstitial GO and KEGG analyses suggested that several pathways may contribute the pathogenesis of DM-ILD-MDA5 Ab(+) and DM-nonILD-MSA16(-), while PPI network analysis of hsa-miR-4488 and hsa-miR5p indicated that their predicted target genes, DExD-box helicase 39B and MDM2, may be involved in the mechanisms of DM-ILD-MDA5 Ab(+). +other 34368147 hsa-mir-19a Pneumonia, Mycoplasma 5p were differentially expressed in LO-PE and cases of small-for-gestational-age newborns, supporting a shared etiology. +other 34368147 hsa-mir-2 PEHO syndrome 5p were differentially expressed in LO-PE and cases of small-for-gestational-age newborns, supporting a shared etiology. +other 34368147 hsa-mir-19a PEHO syndrome 5p were differentially expressed in LO-PE and cases of small-for-gestational-age newborns, supporting a shared etiology. +other 34368147 hsa-mir-2 Pneumonia, Mycoplasma 5p were differentially expressed in LO-PE and cases of small-for-gestational-age newborns, supporting a shared etiology. +other 34368147 hsa-mir-590 Pneumonia, Mycoplasma 5p were differentially expressed in LO-PE and cases of small-for-gestational-age newborns, supporting a shared etiology. +other 34368147 hsa-mir-590 PEHO syndrome 5p were differentially expressed in LO-PE and cases of small-for-gestational-age newborns, supporting a shared etiology. +circulation_biomarker_diagnosis_ns 34368146 hsa-mir-451 Pancreatic Carcinoma ADAM8-dependent co-variates, miR-451 and miR-720 were also diagnostic, as patients with PDAC had significantly higher serum levels of miR-451 and lower serum levels of miR-720 than healthy controls and reached high sensitivity and specificity (AUC = 0.93 and 1.00, respectively) to discriminate PDAC from healthy control. +circulation_biomarker_diagnosis_ns 34368146 hsa-mir-720 Pancreatic Carcinoma ADAM8-dependent co-variates, miR-451 and miR-720 were also diagnostic, as patients with PDAC had significantly higher serum levels of miR-451 and lower serum levels of miR-720 than healthy controls and reached high sensitivity and specificity (AUC = 0.93 and 1.00, respectively) to discriminate PDAC from healthy control. +other 34368141 hsa-mir-29c Adenocarcinoma of Lung This research provides clinical references for LUAD immunotherapy and prognosis and interprets a potential genome instability-related ceRNA regulatory network in which LINC01224-miR5p/miR-29c-3p-CCNF-RRM2 and LINC01224-miR485-5p-PKMYT1-CDK1 axes were the most promising pathways. +other 34368141 hsa-mir-485 Adenocarcinoma of Lung This research provides clinical references for LUAD immunotherapy and prognosis and interprets a potential genome instability-related ceRNA regulatory network in which LINC01224-miR5p/miR-29c-3p-CCNF-RRM2 and LINC01224-miR485-5p-PKMYT1-CDK1 axes were the most promising pathways. +target gene 34368128 hsa-mir-185 Lung Neoplasms Inhibition of miR-185-3p Confers Erlotinib Resistance Through Upregulation of PFKL/MET in Lung Cancers. +lncRNA target 34368091 hsa-mir-34c Acute Lung Injury CONCLUSION: Our results indicate that BMSC-CM may alleviate LPS-induced ALI through miR-34c targeting MARCKS and regulate ENaC indirectly, which further explores the benefit of paracrine effects of bone marrow-derived MSCs on edematous ALI. +genetics_knock down_promote 34367901 hsa-mir-101 Osteosarcoma Overexpressing miR +lncRNA target 34367463 hsa-mir-146a Myocardial Reperfusion Injury Taken together, the results suggest that miR-146a protects against myocardial ischaemia reperfusion injury by inhibiting NOX4 signalling. +circulation_biomarker_prognosis_up 34367281 hsa-mir-21 Pancreatic Carcinoma RESULTS: Serum CA199 and miR-21 levels in the PC group were significantly higher than those in the benign lesion group and control group. +lncRNA target 34367236 hsa-mir-374a Urinary Bladder Neoplasms In conclusion, our results demonstrated that lncRNA KCNMB2-AS1 can promote the progression of bladder cancer through regulation of miR-374a-3p/S100A10. +genetics_knock down_promote 34367233 hsa-mir-637 Ovarian Neoplasms Conclusion: Circ_0013958 knockdown impeded OC development through modulating the miR-637/PLXNB2 axis, highlighting a therapeutic target for OC. +other 34366343 hsa-mir-1909 Alzheimer Disease 3p levels decreased significantly in the aMCI group. +other 34366343 hsa-mir-22 Alzheimer Disease 3p levels decreased significantly in the aMCI group. +other 34366343 hsa-mir-134 Alzheimer Disease 3p levels decreased significantly in the aMCI group. +other 34366343 hsa-mir-1185-2 Alzheimer Disease 3p levels decreased significantly in the aMCI group. +circulation_biomarker_diagnosis_up 34366325 hsa-mir-182 Pleural Effusion, Malignant CONCLUSIONS: miR-21, miR-29c and miR-182 in serum and PF could be useful biomarkers for diagnosis of MPE. +circulation_biomarker_diagnosis_up 34366325 hsa-mir-21 Pleural Effusion, Malignant CONCLUSIONS: miR-21, miR-29c and miR-182 in serum and PF could be useful biomarkers for diagnosis of MPE. +circulation_biomarker_diagnosis_up 34366325 hsa-mir-29c Pleural Effusion, Malignant CONCLUSIONS: miR-21, miR-29c and miR-182 in serum and PF could be useful biomarkers for diagnosis of MPE. +transcription factor target 34366323 hsa-mir-101 Rectal Neoplasms 5p were directly related to rectal cancer through the interaction with the Wnt, RAS, PI3K, and TGF-beta signaling pathways. +transcription factor target 34366323 hsa-mir-17 Rectal Neoplasms 5p were directly related to rectal cancer through the interaction with the Wnt, RAS, PI3K, and TGF-beta signaling pathways. +transcription factor target 34366323 hsa-mir-145 Rectal Neoplasms 5p were directly related to rectal cancer through the interaction with the Wnt, RAS, PI3K, and TGF-beta signaling pathways. +transcription factor target 34366323 hsa-mir-221 Rectal Neoplasms 5p were directly related to rectal cancer through the interaction with the Wnt, RAS, PI3K, and TGF-beta signaling pathways. +circulation_biomarker_diagnosis_up 34366268 hsa-mir-142 Lichen Planus, Oral 3p was detected in the serum, saliva, and tissues samples from patients with OLP. +other 34366240 hsa-let-7c Carcinoma, Hepatocellular RESULTS: Expression levels of let-7c predict tumor relapse after RFA; we also investigated the same panel in a small cohort of HCC patients undergoing surgery, finding no statistically significance in predicting tumor relapse or survival. +other 34365931 hsa-mir-14669 Colorectal Neoplasms OBJECTIVES: This study aimed to identify a novel miRNA-14669 that can reverse vincristine resistance and sensitize drug-resistant colorectal cancer cells. CONCLUSION: We identified a novel miRNA-14669 that may be associated with the chemotherapeutic resistance in CRC cells. +genetics_overexpression_suppress 34365889 hsa-mir-106a Breast Neoplasms Here, our results illustrate that VCAN-AS1 is overexpressed in BC tissues and cells, while miR-106a-5p was downregulated and negatively correlated with VCAN-AS1. In addition, high VCAN-AS1 expression and low miR-106a-5p expression were closely correlated with poor overall survival in BC patients. +genetics_overexpression_suppress 34365839 hsa-mir-15a Stomach Neoplasms In this project, we demonstrated significant overexpression of ONECUT2 and down-regulation of hsa-miR-15a-5p in gastric cancer via bioinformatics analysis and in vitro assays. Then, we separated CD133+/CD44+ MKN45 by flow cytometry and found that, compared with parental MKN45, CD133+/CD44+ MKN45 gastric cancer stem cells (GCSCs) had higher levels of ONECUT2 and lower levels of hsa-miR-15a-5p. +genetics_knock down_promote 34365722 hsa-mir-616 Stomach Neoplasms CES4 knockdown promoted cell viability and inhibited apoptosis of drug-treated HGC-27 and MKN-7 cells by regulating miR +tissue_expression_ns 34364983 hsa-mir-144 Aortic Aneurysm, Abdominal Anti-growth effect of miR3p and related genes was evaluated in a murine AAA model. MiR3p was highly expressed in AAA tissues. miR3p serves as a promoter for the apoptosis of SMCs, which contributes to the occurrence and progression of AAA. +genetics_knock down_suppress 34364880 hsa-mir-378 Myelodysplastic Syndromes A model of aberrant myeloid maturation that mimics MDS was generated using a stable knockdown of miR3p. +other 34363931 hsa-mir-155 Liver Injury CONCLUSIONS: These results indicated that miR-155 played an important role in TP-induced hepatotoxicity by regulating the Nrf2 signaling pathway. +genetics_overexpression_promote 34363308 hsa-mir-199b Squamous Cell Carcinoma of Head and Neck Overexpression of LINC01783 sponged miR-199b-5p in TSCC cell and elevated expression of LINC01783 inhibited miR-199b-5p expression. +other 34363272 hsa-mir-133 Myasthenia Gravis Taken together, our study showed that upregulation of circ-FBL promoted myogenic proliferation in patients with MG by regulating miR-133/PAX7. +exosome 34362882 hsa-mir-101 Inflammation Collectively, this study suggests that the HIF1alpha-dependent suppression of exosome miR101 from hypoxic tumor cells activates macrophages to induce inflammation in the tumor microenvironment. +other 34362591 hsa-mir-367 Uterine Cervical Neoplasms CONCLUSIONS: The up-regulated FEZF1-AS1 could accelerate the malignant behaviors of CC cells by miR3p/SLC12A5 signal axis. +transcription factor target 34362486 hsa-mir-142 Acute Lymphocytic Leukemia, B-Cell 3p Targeting HOXA5 on Proliferation, Cycle Arrest and Apoptosis of Acute B Lymphocytic Leukemia Cells]. +lncRNA target 34362467 hsa-mir-137 Hemangioma, Cavernous CONCLUSION: TUG1 was closely associated with the progression of IH by regulating the miR-137/IGFBP5 axis, which might be a potential target for IH treatment. +lncRNA target 34362407 hsa-mir-335 Triple Negative Breast Neoplasms 5p, and SNHG8 promoted TNBC cell proliferation, migration and EMT process through regulating miR +genetics_knock down_promote 34362391 hsa-mir-381 Breast Neoplasms 3p inhibited breast cancer proliferation and invasion, whereas knockdown of miR +other 34362313 hsa-mir-20a Squamous Cell Carcinoma of Head and Neck CONCLUSION: In conclusion, we have reported a novel CASC18/miR-20a-3p/TGFB2 ceRNA axis in OLNM of TSCC. +genetics_GWAS 34362257 hsa-mir-99a Prostatic Neoplasms Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR +genetics_GWAS 34362257 hsa-mir-100 Prostatic Neoplasms Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR +genetics_GWAS 34362257 hsa-mir-18a Prostatic Neoplasms Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR +genetics_GWAS 34362257 hsa-let-7a Prostatic Neoplasms Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR +genetics_GWAS 34362257 hsa-let-7 Prostatic Neoplasms Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR +genetics_GWAS 34362257 hsa-mir-145 Prostatic Neoplasms Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR +genetics_GWAS 34362257 hsa-mir-24 Prostatic Neoplasms Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR +genetics_knock down_promote 34361070 hsa-mir-7 Thyroid Cancer, Papillary 5p knockdown results in the down-regulation of the iron storage gene expression such as ferritin, up-regulation of the ferroptosis marker ALOX12 gene expression, and increases of Liperfluo amount. +lncRNA target 34360981 hsa-mir-210 Polycystic Ovary Syndrome MicroRNA-210 (miR-210), its target genes (SDHD and GPD1L), and HIF-1alpha-responsive genes (EDN2 and VEGFA) differed in GLCs from PCOS, compared with those of healthy women. +other 34360898 hsa-mir-129a Dysentery Our results have laid the foundation for in-depth study of the mechanism of miR-129a-3p resistance and its application in porcine epidemic diarrhea disease-resistance breeding. +genetics_overexpression_promote 34360898 hsa-mir-129a Postoperative Nausea and Vomiting Overexpression of miR-129a-3p can activate the caspase activation and recruitment domain 11 (CARD11) mediated NF-kappaB pathway, thus inhibiting PEDV replication. +other 34360895 hsa-mir-1 Diabetes Mellitus, Type 2 RESULTS: LncRNA-RP11-773H22.4, together with RET, IGF1R and mTOR mRNAs, showed significant upregulation in T2DM compared with matched controls, while miRNA (i.e., miR-3163 and miR-1) and mRNA (i.e., GLUT4 and AKT2) expression displayed marked downregulation in diabetic samples. +other 34360895 hsa-mir-3163 Diabetes Mellitus, Type 2 RESULTS: LncRNA-RP11-773H22.4, together with RET, IGF1R and mTOR mRNAs, showed significant upregulation in T2DM compared with matched controls, while miRNA (i.e., miR-3163 and miR-1) and mRNA (i.e., GLUT4 and AKT2) expression displayed marked downregulation in diabetic samples. +genetics_overexpression_promote 34360757 hsa-mir-146b Thyroid Neoplasms In thyroid cancer, miR-146b-5p is the most overexpressed miRNA associated with tumor aggressiveness and progression, while the antisense blocking of miR-146b-5p results in anti-tumoral effect. +other 34360711 hsa-mir-762 Brain Ischemia Delivery of exogenous miRNA-762 prior to transplantation significantly increased the post-transplant survival of stem cells and also significantly ameliorated cardiac fibrosis and heart functions following I/R injury. +lncRNA target 34360679 hsa-mir-20a Carcinoma, Renal Cell Identification of miR-20a-5p as Robust Normalizer for Urine microRNA Studies in Renal Cell Carcinoma and a Profile of Dysregulated microRNAs. +other 34360304 hsa-mir-320d Chronic Periodontitis 5p, and hsa-miR-320d were associated with periodontitis progression in patients with chronic periodontitis. +other 34360304 hsa-mir-28 Chronic Periodontitis 5p, and hsa-miR-320d were associated with periodontitis progression in patients with chronic periodontitis. +other 34360304 hsa-mir-99a Chronic Periodontitis 5p, and hsa-miR-320d were associated with periodontitis progression in patients with chronic periodontitis. +other 34360304 hsa-mir-5571 Chronic Periodontitis 5p, and hsa-miR-320d were associated with periodontitis progression in patients with chronic periodontitis. +other 34360304 hsa-let-7f Chronic Periodontitis 5p, and hsa-miR-320d were associated with periodontitis progression in patients with chronic periodontitis. +genetics_knock down_promote 34360007 hsa-mir-126 Cartilage Degradation In sum, the loss of PGC1alpha in chondrocytes due to upregulation of miR5p during OA pathogenesis resulted in the activation of PRKN-independent mitophagy through the upregulation of BNIP3 and stimulated cartilage degradation and apoptotic death of chondrocytes. +other 34360002 hsa-mir-214 Muscular Dystrophy, Duchenne 3p is a key activator of FAP fibrogenesis by modulating the FGF2/FGFR1/TGFbeta axis, opening new avenues for the treatment of DMD. +other 34359879 hsa-mir-132 Brain Ischemia The effects of miRNA-132/212 gene-deletion on hippocampal synaptic transmission and levels of cholinergic-signaling elements suggest the existence of a miRNA-132/212-dependent adaptive mechanism safeguarding the functional integrity of synaptic functions in the acute phase of cerebral ischemia. +circulation_biomarker_diagnosis_ns 34359778 hsa-mir-17 Multiple Myeloma 5p were significantly higher in the blood plasma of MM patients with MMBD compared to those without. +circulation_biomarker_prognosis_ns 34359778 hsa-mir-335 Multiple Myeloma 5p were significantly higher in the blood plasma of MM patients with MMBD compared to those without. +circulation_biomarker_prognosis_ns 34359778 hsa-let-7b Multiple Myeloma 5p were significantly higher in the blood plasma of MM patients with MMBD compared to those without. +circulation_biomarker_diagnosis_ns 34359778 hsa-mir-143 Multiple Myeloma 5p were significantly higher in the blood plasma of MM patients with MMBD compared to those without. +circulation_biomarker_diagnosis_ns 34359778 hsa-mir-214 Multiple Myeloma 5p were significantly higher in the blood plasma of MM patients with MMBD compared to those without. +other 34359739 hsa-mir-655 Breast Neoplasms We reported that two microRNAs, miR526b and miR655, are oncogenic in breast cancer (BC). +circulation_biomarker_diagnosis_ns 34359739 hsa-mir-526b Breast Neoplasms Additionally, with a case-control cohort study, we identified that high expression of pri-miR526b in the blood is also a risk factor associated with breast cancer (OR = 4.3, CI = 1.39-13.34, p = 0.01). +other 34358482 hsa-mir-21 Breast Neoplasms The expression of SPTBN1, EMT-related genes, and miRNA21 in breast cancer cells and tissues were assessed by quantitative real-time polymerase chain reaction (qPCR) and Western blot. +other 34358374 hsa-mir-6868 Squamous Cell Carcinoma of Head and Neck CONCLUSION: H3K27ac-induced FOXC2-AS1 exhibits carcinogenic property in TSCC by the miR5p/E2F3 axis. +circulation_biomarker_diagnosis_ns 34357821 hsa-mir-765 Diabetes Mellitus, Type 2 By qRT-PCR and western blotting, miR-765 with high expression and PDX1 with low expression were observed in blood samples from T2DM patients and the T2DM cell model. +circulation_biomarker_diagnosis_ns 34357569 hsa-mir-192 Atherosclerosis The expression level of serum miR +other 34357552 hsa-mir-149 Parkinson Disease 5p has decreased, followed by PD induction in rats. +lncRNA target 34357507 hsa-mir-582 Colorectal Neoplasms 5p and its target gene TNKS2 could be novel biomarkers for metastatic disease prediction, overall prognosis evaluation, as well as potential therapeutic target for colorectal cancer patients. +genetics_knock down_promote 34357490 hsa-mir-195 Glioma CONCLUSION: Knockdown of Circ_CLIP2 suppresses glioma progression by targeting miR +circulation_biomarker_diagnosis_up 34357372 hsa-mir-222 Colorectal Neoplasms Here, we found that the blood levels of miR-221 and miR-222 were dramatically increased in patients with colorectal cancer (CRC), and both circulating miR-211 and miR-222 served as sensitive diagnostic markers with an area under the curve of 0.8790 and 0.9148, respectively. These data showed that miR-221/222 levels were upregulated in the blood of patients with CRC and that the expression of CD4 in human primary T cells was inhibited by miR-221/222. +circulation_biomarker_diagnosis_up 34357372 hsa-mir-221 Colorectal Neoplasms Here, we found that the blood levels of miR-221 and miR-222 were dramatically increased in patients with colorectal cancer (CRC), and both circulating miR-211 and miR-222 served as sensitive diagnostic markers with an area under the curve of 0.8790 and 0.9148, respectively. These data showed that miR-221/222 levels were upregulated in the blood of patients with CRC and that the expression of CD4 in human primary T cells was inhibited by miR-221/222. +other 34356909 hsa-mir-6821 Pancreatic Carcinoma Six miRNAs were independently correlated with early PDAC, and among these, hsa-miR5p was associated with the best ROC curve area in distinguishing controls from early PDAC. +other 34356894 hsa-mir-181b Pulmonary Disease, Chronic Obstructive Expression of miR-181b-3p, miR-429 and miR-23c (all p < 0.05) was increased in COPD. +other 34356894 hsa-mir-181b Lung Neoplasms Expression of miR-181b-3p, miR-429 and miR-23c (all p < 0.05) was increased in COPD. +other 34356894 hsa-mir-23c Pulmonary Disease, Chronic Obstructive Expression of miR-181b-3p, miR-429 and miR-23c (all p < 0.05) was increased in COPD. +other 34356894 hsa-mir-23c Lung Neoplasms Expression of miR-181b-3p, miR-429 and miR-23c (all p < 0.05) was increased in COPD. +other 34356879 hsa-mir-142a Acute Kidney Injury 3p, in the injured kidneys at various time points. +other 34356879 hsa-mir-146a Acute Kidney Injury 3p, in the injured kidneys at various time points. +other 34356879 hsa-mir-214 Acute Kidney Injury 3p, in the injured kidneys at various time points. +other 34356879 hsa-mir-199a Acute Kidney Injury 3p, in the injured kidneys at various time points. +other 34356879 hsa-mir-223 Acute Kidney Injury 3p, in the injured kidneys at various time points. +circulation_biomarker_diagnosis_down 34356875 hsa-mir-23b Carcinoma, Hepatocellular miR-23b-3p was further measured by ddPCR in 37 healthy individuals and 25 untreated HCC patients. The amount of miR-23b-3p in the plasma of untreated HCC patients was significantly downregulated if compared to healthy individuals. +other 34356850 hsa-mir-424 Ischemic Stroke Patients with CSC ischaemic stroke showed a lower expression of miR-15a, miR-424, miR-100, and miR-339 compared with those with SC ischaemic stroke, and the levels of miR-339, miR-100, miR-199a, miR-369a, miR-424, and miR-15a were lower than those of the HCs. +other 34356850 hsa-mir-339 Ischemic Stroke Patients with CSC ischaemic stroke showed a lower expression of miR-15a, miR-424, miR-100, and miR-339 compared with those with SC ischaemic stroke, and the levels of miR-339, miR-100, miR-199a, miR-369a, miR-424, and miR-15a were lower than those of the HCs. +other 34356850 hsa-mir-369a Ischemic Stroke Patients with CSC ischaemic stroke showed a lower expression of miR-15a, miR-424, miR-100, and miR-339 compared with those with SC ischaemic stroke, and the levels of miR-339, miR-100, miR-199a, miR-369a, miR-424, and miR-15a were lower than those of the HCs. +other 34356850 hsa-mir-100 Ischemic Stroke Patients with CSC ischaemic stroke showed a lower expression of miR-15a, miR-424, miR-100, and miR-339 compared with those with SC ischaemic stroke, and the levels of miR-339, miR-100, miR-199a, miR-369a, miR-424, and miR-15a were lower than those of the HCs. +other 34356850 hsa-mir-199a Ischemic Stroke Patients with CSC ischaemic stroke showed a lower expression of miR-15a, miR-424, miR-100, and miR-339 compared with those with SC ischaemic stroke, and the levels of miR-339, miR-100, miR-199a, miR-369a, miR-424, and miR-15a were lower than those of the HCs. +other 34356850 hsa-mir-15a Ischemic Stroke Patients with CSC ischaemic stroke showed a lower expression of miR-15a, miR-424, miR-100, and miR-339 compared with those with SC ischaemic stroke, and the levels of miR-339, miR-100, miR-199a, miR-369a, miR-424, and miR-15a were lower than those of the HCs. +lncRNA target 34356844 hsa-mir-138 Glioblastoma Previously, we found miR-138 as one of tumor suppressive miRNAs that were significantly down-regulated in GBM. +other 34356708 hsa-mir-21 Lung Neoplasms Here, a paper-based electrochemical biosensor was developed for the rapid and sensitive detection of microRNAs (miRNA-155 and miRNA-21) related to early diagnosis of lung cancer. +other 34356708 hsa-mir-155 Lung Neoplasms Here, a paper-based electrochemical biosensor was developed for the rapid and sensitive detection of microRNAs (miRNA-155 and miRNA-21) related to early diagnosis of lung cancer. +genetics_overexpression_promote 34356658 hsa-mir-1290 Squamous Cell Carcinoma of Head and Neck We have shown previously that the overexpressed miR-1290 influences MAF protein levels in LSCC (laryngeal squamous cell carcinoma) cell lines. +other 34356656 hsa-mir-545 Kidney Diseases These findings provided new perceptions of the unique regulation of the miR3p-TNFSF10 interaction and their potential therapeutic effect in kidney injury induced by hypoxia. +transcription factor target 34356508 hsa-mir-181 Liver Diseases These results indicate that CVS results in liver damage and induces hepatic Fe(II) accumulation, which is closely associated with the up-regulation of ZIP14 expression via the miR-181 family pathway. +lncRNA target 34356326 hsa-mir-122 Carcinoma, Hepatocellular Furthermore, microRNA antisense-targeted sites for miR122, known to be widely expressed in normal hepatocytes while downregulated in hepatocellular carcinoma, were added to specifically limit cytotoxicity in HCC cells, thereby limiting the off-target effects. +other 34356073 hsa-mir-29a Fabry Nephropathy However, we found increased expression of miR-29a-3p and miR-200a-3p in uEVs isolated from chronological samples of patients with Fabry nephropathy. +other 34356073 hsa-mir-200a Fabry Nephropathy However, we found increased expression of miR-29a-3p and miR-200a-3p in uEVs isolated from chronological samples of patients with Fabry nephropathy. +lncRNA target 34355838 hsa-mir-577 Myocardial Infarction, Acute Overall, NORAD aggravates acute myocardial infarction by promoting fibrosis and apoptosis via the miR-577/COBLL1 axis. +circulation_biomarker_diagnosis_ns 34355706 hsa-mir-26b Colonic Neoplasms Long Noncoding RNA Plasmacytoma Variant Translocation 1 (PVT1) Promotes Colon Cancer Progression via Endogenous Sponging miR-26b. +lncRNA target 34355586 hsa-mir-188 Carcinoma, Hepatocellular 3p and miR-133b exert a suppressive effect on hepatocellular carcinoma proliferation, invasion, and migration through downregulation of NDRG1. +lncRNA target 34355586 hsa-mir-133b Carcinoma, Hepatocellular 3p and miR-133b exert a suppressive effect on hepatocellular carcinoma proliferation, invasion, and migration through downregulation of NDRG1. +circulation_biomarker_diagnosis_down 34355355 hsa-mir-129 Hypoxia-Ischemia, Brain 5p was revealed to be downregulated in the serum of patients with IBI. +circulation_biomarker_diagnosis_ns 34355070 hsa-mir-148a Carcinoma, Hepatocellular RESULTS: Patients with HCC had lower plasma miRNA 148a-3p, higher serum TGF-beta1, and higher FIB-4 levels than patients with cirrhosis and controls. +other 34355069 hsa-mir-182 Stomach Neoplasms 5p were down regulated in gastric cancer patients in Group I more than Groups II and III (P < 0.001). +other 34355036 hsa-mir-191 Infertility We identified 15 differentially expressed miRNAs between high- and low-fertility bulls, nine of which are known (miR-2285n, miR-378, miR3p, miR-191, miR-2904, miR-378c, miR-431, miR-486, miR-2478) while the remaining are novel. +other 34355036 hsa-mir-486 Infertility We identified 15 differentially expressed miRNAs between high- and low-fertility bulls, nine of which are known (miR-2285n, miR-378, miR3p, miR-191, miR-2904, miR-378c, miR-431, miR-486, miR-2478) while the remaining are novel. +other 34355036 hsa-mir-378c Infertility We identified 15 differentially expressed miRNAs between high- and low-fertility bulls, nine of which are known (miR-2285n, miR-378, miR3p, miR-191, miR-2904, miR-378c, miR-431, miR-486, miR-2478) while the remaining are novel. +other 34355036 hsa-mir-2904 Infertility We identified 15 differentially expressed miRNAs between high- and low-fertility bulls, nine of which are known (miR-2285n, miR-378, miR3p, miR-191, miR-2904, miR-378c, miR-431, miR-486, miR-2478) while the remaining are novel. +other 34355036 hsa-mir-2478 Infertility We identified 15 differentially expressed miRNAs between high- and low-fertility bulls, nine of which are known (miR-2285n, miR-378, miR3p, miR-191, miR-2904, miR-378c, miR-431, miR-486, miR-2478) while the remaining are novel. +other 34355036 hsa-mir-378 Infertility We identified 15 differentially expressed miRNAs between high- and low-fertility bulls, nine of which are known (miR-2285n, miR-378, miR3p, miR-191, miR-2904, miR-378c, miR-431, miR-486, miR-2478) while the remaining are novel. +other 34355036 hsa-mir-431 Infertility We identified 15 differentially expressed miRNAs between high- and low-fertility bulls, nine of which are known (miR-2285n, miR-378, miR3p, miR-191, miR-2904, miR-378c, miR-431, miR-486, miR-2478) while the remaining are novel. +other 34355036 hsa-mir-2285n Infertility We identified 15 differentially expressed miRNAs between high- and low-fertility bulls, nine of which are known (miR-2285n, miR-378, miR3p, miR-191, miR-2904, miR-378c, miR-431, miR-486, miR-2478) while the remaining are novel. +lncRNA target 34354942 hsa-mir-766 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Further, CDKN1A was proved to be the target gene of miR +transcription factor target 34354862 hsa-mir-196b Esophageal Squamous Cell Carcinoma Taken together, these findings suggest that miR-196b is a strong candidate molecular target for EC treatment. +transcription factor target 34354409 hsa-mir-186 Osteoarthritis, Knee In light of this evidence, we propose that molecular therapeutic interventions targeting miR-186 activation might attenuate osteoarthritic cartilage degeneration. +target gene 34354393 hsa-mir-485 Ovarian Neoplasms E74-like factor 3 suppresses microRNA-485-5p transcription to trigger growth and metastasis of ovarian cancer cells with the involvement of CLDN4/Wnt/β-catenin axis. +lncRNA target 34354391 hsa-mir-216a Asthma LncRNA MALAT1 and microRNA-216a are involved in the regulation of AMSCs respectively, but there is no research to prove that they can regulate airway remodeling of asthma through mutual combination. +circulation_biomarker_diagnosis_ns 34354365 hsa-mir-486 Sepsis Kaplan-Meier estimator and Cox regression hazards analysis of the predictive significance of serum miR +lncRNA target 34354043 hsa-mir-4793 Stomach Neoplasms 3p as a ceRNA to eliminate the negative regulation of FOXO1, therefore suppressing GC proliferation. +lncRNA target 34354038 hsa-mir-204 Alzheimer Disease The overall results demonstrated that inhibition of miR-204 prevents axonal dystrophy by blocking BRUCE interaction with STX17, which unraveled potential novel therapeutic targets for delaying AD. +lncRNA target 34353856 hsa-mir-766 Histiocytic Sarcoma Moreover, miR5p suppressed expression of a BRD4-NUT fusion protein that drives NUT midline carcinoma. +genetics_overexpression_suppress 34353082 hsa-mir-449 Arthritis, Rheumatoid HDAC1 overexpression reversed the biological effects of miR-449 on RASFs (P<0.001). +lncRNA target 34352998 hsa-mir-4487 Carcinoma, Non-Small-Cell Lung MATERIALS AND METHODS: To examine the physiological roles of miR-4487 and ubiquitin-specific peptidase 37 (USP37) in gefitinib-mediated EGFR degradation in NSCLC cells, multiple NSCLC cell lines were applied. CONCLUSION: These data suggest that miR-4487 is a potential target for treating NSCLC, and miR-4487/USP37-regulated EGFR degradation is a determinant for developing gefitinib resistance. +genetics_overexpression_promote 34352938 hsa-mir-451a Breast Neoplasms Overexpression of miR-451a repressed BC cells proliferation, migration and invasion. +lncRNA target 34352791 hsa-mir-101 Lung Neoplasms 3p could be a potential target of XIST through direct binding with it as a competing endogenous RNA, which was further validated from lung tumor tissues and cell lines by luciferase assay. +transcription factor target 34352784 hsa-mir-182 Diabetic Retinopathy CONCLUSION: APS alleviated mitochondrial damage and apoptosis induced by metabolic memory by regulating the miR-182/Bcl-2 axis, which might serve as a new strategy for the treatment of diabetic retinopathy. +other 34352236 hsa-mir-29a Pneumonia, Mycoplasma RESULTS: TUG1 and VEGFA levels were downregulated, and levels of miR-29a-3p, sFLT1 and sENG were increased in PE patients. +other 34352040 hsa-mir-20b Ovarian Neoplasms 3p, CA-125 and HE4). +other 34352040 hsa-mir-141 Ovarian Neoplasms 3p, CA-125 and HE4). +genetics_overexpression_promote 34351868 hsa-mir-106b Adenocarcinoma of Lung Moreover, inhibition of miR-106b-5p significantly decreased in vitro proliferation, migration, and invasion by LUAD cells, whereas miR-106b-5p overexpression reversed those effects. +genetics_overexpression_promote 34351577 hsa-mir-299 Breast Neoplasms However, inhibition of miR-299 or overexpression of BACH1 could reverse the inhibitory effects of sh-SNHG5 on cell proliferation and glycolysis in BC. +circulation_biomarker_diagnosis_up 34351574 hsa-mir-197 Mucocutaneous Lymph Node Syndrome 3p and its target, TIMP3, are dramatically variational in KD serum and HCAECs cultured with KD serum. +lncRNA target 34351558 hsa-mir-1298 Myocardial Reperfusion Injury This study aims to investigate the function and specific mechanism of miR-1298 in myocardial ischemia/reperfusion (IR) injury. MiR-1298 participated in myocardial I/R injury by targeting the PP2A/AMPK/GSK3beta signaling pathway, suggesting that miR-1298 might be a potential therapeutic target for myocardial I/R injury. +circulation_biomarker_diagnosis_ns 34350970 hsa-mir-150 Leukemia, Myelogenous, Chronic, BCR-ABL Positive OBJECTIVE: To assess the circulating micro-RNA-150 (miR-150) expression in patients with chronic myeloid leukemia (CML) in relation to imatinib response. +exosome 34350954 hsa-mir-21 Atherosclerosis In conclusion, MSC-derived exosomes containing miR-21a-5p promote macrophage polarization and reduce macrophage infiltration by targeting KLF6 and ERK1/2 signaling pathways, thereby attenuating the development of AS. +other 34350836 hsa-mir-7 Intervertebral Disc Degeneration 5p/ACVR2B, P3H2; TRG-AS1/ hsa-let-7e-5p/FZD3, ACVR2B; and ZNF571-AS1/let-7e-5p/ACVR2B, FZD3. +other 34350836 hsa-mir-574 Intervertebral Disc Degeneration 5p/ACVR2B, P3H2; TRG-AS1/ hsa-let-7e-5p/FZD3, ACVR2B; and ZNF571-AS1/let-7e-5p/ACVR2B, FZD3. +other 34350836 hsa-let-7e Intervertebral Disc Degeneration 5p/ACVR2B, P3H2; TRG-AS1/ hsa-let-7e-5p/FZD3, ACVR2B; and ZNF571-AS1/let-7e-5p/ACVR2B, FZD3. +other 34350834 hsa-mir-100 Atrial Fibrillation Connectivity Map and Comparative Toxicogenomics Database searches predicted dexamethasone may treat AF by reversing the expression of MIR100HG; artemisinin may reverse the expression of hub DEGs. +genetics_knock down_suppress 34350748 hsa-mir-744 Reperfusion Injury, Cerebral Ischemia LINC00665 knockdown was validated to project CI/R injury by sponging miR5p expression. +lncRNA target 34350720 hsa-mir-34a Osteoporosis Taken together, our study revealed the key role of the lncRNA TUG1/miR-34a/FGFR1 axis in FSS-regulated osteoblast proliferation and apoptosis and may provide potential therapeutic targets for osteoporosis. +genetics_GWAS 34350711 hsa-let-7d Pre-Eclampsia Such an epigenetic network of let-7d, KDM3A and ENO2 in the pathogenesis of PE might provide novel insight into targeted therapy against this disorder. +lncRNA target 34350661 hsa-mir-4455 Uterine Cervical Neoplasms CONCLUSIONS: Inhibition of UNC5B-AS1/miR-4455/RSPO4 reduces CC growth both in vitro and in vivo, furnishing new insights into molecular studies on UNC5B-AS1 with respect to CC development. +other 34350290 hsa-mir-124 Osteosarcoma By using the KM Plotter software, miRNA-124 and ARHGEF3 were obviously associated with the overall survival of patients with osteosarcoma. +target gene 34350182 hsa-mir-214 Uterine Cervical Neoplasms SPINT1-AS1 Drives Cervical Cancer Progression via Repressing miR-214 Biogenesis. +other 34350110 hsa-mir-145 Breast Neoplasms PCDHB17P/miR-145-3p/MELK/NF-κB Feedback Loop Promotes Metastasis and Angiogenesis of Breast Cancer. +exosome 34349799 hsa-mir-665 Lung Neoplasms Exosomal lncRNA SCIRT/miR-665 Transferring Promotes Lung Cancer Cell Metastasis through the Inhibition of HEYL. +lncRNA target 34349786 hsa-mir-16-2 Pneumoconiosis We found miR2-3p may used as biomarker for REP, because it is closely related to the occurrence and prognosis of REP through inflammatory reaction and in lung squamous cell carcinoma, its expression levels were positively correlated with the overall survival rate of patients. +genetics_overexpression_suppress 34349660 hsa-mir-192 Diabetic Nephropathies 5p overexpression-induced fibrosis production and autophagy limitation. +other 34349559 hsa-mir-4284 Carcinoma, Non-Small-Cell Lung miR-4284 Promotes Cell Proliferation, Migration, and Invasion in Non-Small Cell Lung Cancer Cells and is Associated with Postoperative Prognosis. +other 34349427 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck The comparative Ct method was used to analyze the differences in subsite specific expression of miR-21 in OSCC cases. +target gene 34349351 hsa-mir-17 Uterine Cervical Neoplasms miR-17-5p accelerates cervical cancer cells migration and invasion via the TIMP2/MMPs signaling cascade. +lncRNA target 34349349 hsa-mir-182 Carcinoma, Renal Cell Our experimental data further showed that miR-182 could be delivered by MSC-Exo in ccRCC, which targeted vascular endothelial growth factor A (VEGFA), as dual-luciferase reporter assays validated. In conclusion, miR-182 contained in MSC-Exo promoted immune response of T cells by suppressing VEGFA expression, thus alleviating ccRCC development. +target gene 34349348 hsa-mir-185 Uterine Cervical Neoplasms miR-185-3p targets Annexin-A8 to inhibit proliferation in cervical cancer cells. +genetics_knock down_promote 34349347 hsa-mir-545 Carcinoma, Non-Small-Cell Lung 3p could abate the effects of circ_0014130 knockdown in DTX-resistant NSCLC cells in vitro, whereas its overexpression exerted similar effects of circ_0014130 knockdown. +target gene 34349344 hsa-mir-103a Liver Neoplasms Inhibiting roles of FOXA2 in liver cancer cell migration and invasion by transcriptionally suppressing microRNA-103a-3p and activating the GREM2/LATS2/YAP axis. +lncRNA target 34348712 hsa-mir-212 Carcinoma, Hepatocellular Further studies revealed that circFAM13B, a sponge of miR-212, is involved in the regulation of E2F5 gene expression by competitively binding to miR-212, inhibits the activation of the P53 signalling pathway, and promotes the proliferation of HCC cells. CONCLUSIONS: Our findings revealed the mechanism underlying the regulatory role played by circFAM13B, miR-212 and E2F5 in HCC. +circulation_biomarker_diagnosis_ns 34348591 hsa-mir-155 Acquired Immunodeficiency Syndrome T cell immune activation was detected by the expression of CD38 via flow cytometry.Results: The levels of miR-155 in the total peripheral blood mononuclear cells, CD4+, and CD8+ T cells from HIV-1 patients were increased (p < 0.01). MiR-155 level was positively related to immune activation of T cells.Conclusion: Our findings suggest that miR-155 levels in circulating T cells of HIV-1 patients are increased and associated with T cell activation. +lncRNA target 34348465 hsa-mir-520a Osteosarcoma miR-520a-3p targeted GAB1 to repress OS cell proliferation and metastasis. +genetics_knock down_suppress 34348296 hsa-mir-148a Epilepsy, Temporal Lobe miR-148a-3p is overexpressed and associated with seizure frequency and FS history and serves as a novel diagnostic biomarker in TLE. +genetics_overexpression_promote 34348265 hsa-mir-345 Glioma When expression of hsa_circ_0073237 and miR-345 was inhibited simultaneously, cell viability, apoptosis, and invasion did not change significantly; however, after transfection with HDGF overexpression vector, the effects of hsa_circ_0073237 siRNA and miR-345 on glioma cell viability, apoptosis, and invasion were obviously reversed. +genetics_overexpression_promote 34347980 hsa-mir-18a Endometrial Neoplasms In addition, rescue experiments revealed that the oncogenic effect of miR-18a-5p on EC cells was inhibited by THBD overexpression. +genetics_knock down_suppress 34347977 hsa-mir-543 Small Cell Lung Carcinoma It also showed that knockdown of miR-543 can inhibit the proliferation and migration of SCLC cells, induce apoptosis, and increase the level of apoptosis-related proteins. +lncRNA target 34346845 hsa-mir-195 Carcinoma, Non-Small-Cell Lung 5p/E2F3 axis, promotes NSCLC progression, which is a promising therapeutic target for NSCLC. +lncRNA target 34346538 hsa-mir-34a Polycystic Ovary Syndrome Under such context, the present study aimed to investigate the mechanism underlying the involvement of ox-HDL in PCOS in relation to the p65/micro-RNA-34a (miR-34a)/FOS axis. In conclusion, our findings suggested that ox-HDL promoted the activation of p65 and transcription of miR-34a, which stimulated apoptosis of GCs and inhibited expression of FOS, resulting in the overall acceleration of PCOS development. +genetics_knock down_promote 34346534 hsa-mir-223 Respiratory Distress Syndrome Finally, we found that OIP5-AS1 knockdown and miR-223 overexpression could both alleviate LPS-induced ALI/ARDS in vivo. +genetics_knock down_promote 34346534 hsa-mir-223 Acute Lung Injury Finally, we found that OIP5-AS1 knockdown and miR-223 overexpression could both alleviate LPS-induced ALI/ARDS in vivo. +other 34346250 hsa-mir-29b Penile Induration CONCLUSION: Although our study has a small sample, we showed for the first time an evidence that the downregulation of miR-29b is associated with PD. +other 34346162 hsa-mir-150 Osteosarcoma Thus, these findings demonstrate that EGR1/ LINC00857/miR5p/c-Myc axis plays a key role in promoting anticancer effects of Scutellarin and Scutellarin might have potential clinical implication in osteosarcoma clinical treatment. +genetics_knock down_promote 34346032 hsa-mir-370 Thyroid Cancer, Papillary Taken together, CircUBAP2 knockdown impeded the proliferation and invasion and induced apoptosis in TC cells via sponging miR +genetics_knock down_promote 34346000 hsa-mir-132 Acute Lung Injury LncRNA XIST knockdown alleviates LPS-induced acute lung injury by inactivation of XIST/miR-132-3p/MAPK14 pathway : XIST promotes ALI via miR-132-3p/MAPK14 axis. +target gene 34345298 hsa-mir-654 Thyroid Neoplasms Inhibition of circular RNA_0000285 prevents cell proliferation and induces apoptosis in thyroid cancer by sponging microRNA-654-3p. +genetics_knock down_suppress 34345289 hsa-mir-125b Squamous Cell Carcinoma of Head and Neck miR-125b-5p expression was downregulated in LSCC tissues and cells as determined using RT-qPCR. In conclusion, knockdown of circ_0001883 inhibited cell migration, invasion and EMT of LSCC by sponging miR-125b-5p. +genetics_knock down_promote 34345283 hsa-mir-758 Osteoarthritis, Knee 3p affects the proliferation of synovial cells and the expression of relevant proteins in these cells, thus promoting the occurrence and development of KOA. +lncRNA target 34345281 hsa-mir-200c Asthma Inhibition of miR-200c-3p reversed the suppression of asthmatic inflammation by MIM. +lncRNA target 34345270 hsa-mir-451a Granulomatosis with Polyangiitis KGN cells were transfected with miR-451a inhibitor or inhibitor control sequences for 6 h and treated with 10 microg/ml propofol for an additional 48 h. +lncRNA target 34345270 hsa-mir-451a Polycystic Ovary Syndrome However, the diagnostic applications of miR-451a in PCOS remain unknown. In addition, the data indicated that miR-451a may be used as an effective therapeutic target for PCOS treatment. +other 34345264 hsa-mir-16 Acute Lung Injury Overall, these aforementioned findings suggest that miR-16 may serve a protective role against LPS-mediated inflammatory responses in NHBE cells by regulating TLR4, where this mechanism may be considered to be a novel approach for treating ALI in the future. +lncRNA target 34345220 hsa-mir-216 Breast Neoplasms Taken together, our findings indicated that miR-216 down-regulates HK2 to inactivate the mTOR signaling pathway, thus inhibiting the progression of BC. +lncRNA target 34345208 hsa-mir-21 Spinal Cord Injuries Collectively, our findings demonstrate that targeting miR-21a-5p represents a prospective therapy for promoting the recovery of TSCI. +lncRNA target 34345208 hsa-mir-21 Inflammation Collectively, our findings demonstrate that targeting miR-21a-5p represents a prospective therapy for promoting the recovery of TSCI. +lncRNA target 34345178 hsa-mir-221 Osteitis Key microRNAs (hsa-miR-144, hsa-miR-21, and hsa-miR-221) and TFs (RELA and NFKB1) were predicted to be correlated with the pathogenesis of inflammatory osteolysis through microRNA-TF regulatory network analysis. Hub genes including IL1beta, CXCL1, ICAM1, CCL5, and CCL4, key microRNAs (hsa-miR-144, hsa-miR-21, and hsa-miR-221) and TFs (RELA and NFKB1) may serve as prognostic and therapeutic targets of inflammatory osteolysis. +lncRNA target 34345178 hsa-mir-21 Osteitis Key microRNAs (hsa-miR-144, hsa-miR-21, and hsa-miR-221) and TFs (RELA and NFKB1) were predicted to be correlated with the pathogenesis of inflammatory osteolysis through microRNA-TF regulatory network analysis. Hub genes including IL1beta, CXCL1, ICAM1, CCL5, and CCL4, key microRNAs (hsa-miR-144, hsa-miR-21, and hsa-miR-221) and TFs (RELA and NFKB1) may serve as prognostic and therapeutic targets of inflammatory osteolysis. +lncRNA target 34345178 hsa-mir-144 Osteitis Key microRNAs (hsa-miR-144, hsa-miR-21, and hsa-miR-221) and TFs (RELA and NFKB1) were predicted to be correlated with the pathogenesis of inflammatory osteolysis through microRNA-TF regulatory network analysis. Hub genes including IL1beta, CXCL1, ICAM1, CCL5, and CCL4, key microRNAs (hsa-miR-144, hsa-miR-21, and hsa-miR-221) and TFs (RELA and NFKB1) may serve as prognostic and therapeutic targets of inflammatory osteolysis. +circulation_biomarker_diagnosis_ns 34344968 hsa-mir-223 Substance-Related Disorders We revealed that the circulating levels of IL-18, NETs, and miR-223 were significantly higher in active AOSD patients, compared with inactive AOSD patients or healthy controls (P < 0.005). +transcription factor target 34344968 hsa-mir-223 Hereditary Autoinflammatory Diseases MiR-223, mROS inhibitors, and calcium channel blockers are the potential therapeutics for autoinflammatory diseases such as AOSD. +transcription factor target 34344912 hsa-mir-4057 Thinness Notably, 43/572 (8%) of the mRNAs associated with underweight status in male placentas were also gene targets of two miRNAs (miR-4057 and miR1-5p) associated with underweight status in male placentas. +transcription factor target 34344912 hsa-mir-128-1 Thinness Notably, 43/572 (8%) of the mRNAs associated with underweight status in male placentas were also gene targets of two miRNAs (miR-4057 and miR1-5p) associated with underweight status in male placentas. +exosome 34344478 hsa-mir-21 Cicatrix CONCLUSION: The effect of UCB-MSCs in stimulating regenerative wound healing might be achieved through exosomes, which can be, in part, through miR5p- and miR-125b-5p-mediated TGF-beta receptor inhibition, suggesting that UCB-MSC-exo might represent a novel strategy to prevent scar formation during wound healing. +other 34344478 hsa-mir-21 Huntington Disease Using miRNA mimics, we found that miR5p and miR-125b-5p were critical for anti-myofibroblast differentiation in the TGF-beta1-induced HDF. +exosome 34344478 hsa-mir-125b Wounds and Injuries CONCLUSION: The effect of UCB-MSCs in stimulating regenerative wound healing might be achieved through exosomes, which can be, in part, through miR5p- and miR-125b-5p-mediated TGF-beta receptor inhibition, suggesting that UCB-MSC-exo might represent a novel strategy to prevent scar formation during wound healing. +other 34344478 hsa-mir-125b Huntington Disease Using miRNA mimics, we found that miR5p and miR-125b-5p were critical for anti-myofibroblast differentiation in the TGF-beta1-induced HDF. +exosome 34344478 hsa-mir-125b Cicatrix CONCLUSION: The effect of UCB-MSCs in stimulating regenerative wound healing might be achieved through exosomes, which can be, in part, through miR5p- and miR-125b-5p-mediated TGF-beta receptor inhibition, suggesting that UCB-MSC-exo might represent a novel strategy to prevent scar formation during wound healing. +exosome 34344478 hsa-mir-21 Wounds and Injuries CONCLUSION: The effect of UCB-MSCs in stimulating regenerative wound healing might be achieved through exosomes, which can be, in part, through miR5p- and miR-125b-5p-mediated TGF-beta receptor inhibition, suggesting that UCB-MSC-exo might represent a novel strategy to prevent scar formation during wound healing. +circulation_biomarker_diagnosis_ns 34344352 hsa-mir-29a Obesity CONCLUSION: The change in the serum miR-29a, miR-122 and sestrin2 levels in obese children with/without T2DM may suggest a possible role of these biomarkers in the pathogenesis of childhood obesity and their accompanied complications e.g. +circulation_biomarker_diagnosis_ns 34344352 hsa-mir-122 Obesity CONCLUSION: The change in the serum miR-29a, miR-122 and sestrin2 levels in obese children with/without T2DM may suggest a possible role of these biomarkers in the pathogenesis of childhood obesity and their accompanied complications e.g. +circulation_biomarker_diagnosis_ns 34344352 hsa-mir-122 Diabetes Mellitus, Type 2 CONCLUSION: The change in the serum miR-29a, miR-122 and sestrin2 levels in obese children with/without T2DM may suggest a possible role of these biomarkers in the pathogenesis of childhood obesity and their accompanied complications e.g. +circulation_biomarker_diagnosis_ns 34344352 hsa-mir-29a Diabetes Mellitus, Type 2 CONCLUSION: The change in the serum miR-29a, miR-122 and sestrin2 levels in obese children with/without T2DM may suggest a possible role of these biomarkers in the pathogenesis of childhood obesity and their accompanied complications e.g. +other 34343969 hsa-mir-371a Testicular Germ Cell Tumor This research identified that miR-371a-3p has a high diagnostic value for TGCTs, except teratoma. +transcription factor target 34343834 hsa-mir-96 Osteosarcoma 5p may function as an effective target in OS treatment. +circulation_biomarker_diagnosis_up 34343725 hsa-mir-19b COVID-19 These results suggest that plasma miR-19a-3p, miR-19b-3p, and miR-92a-3p expression levels could serve as potential diagnostic biomarker and/or a putative therapeutic target during SARS-CoV +circulation_biomarker_diagnosis_up 34343725 hsa-mir-92a COVID-19 These results suggest that plasma miR-19a-3p, miR-19b-3p, and miR-92a-3p expression levels could serve as potential diagnostic biomarker and/or a putative therapeutic target during SARS-CoV +circulation_biomarker_diagnosis_up 34343725 hsa-mir-19a COVID-19 These results suggest that plasma miR-19a-3p, miR-19b-3p, and miR-92a-3p expression levels could serve as potential diagnostic biomarker and/or a putative therapeutic target during SARS-CoV +circulation_biomarker_diagnosis_ns 34343125 hsa-mir-215 Carcinoma, Hepatocellular METHODOLOGY The gene expression of mature miRNA -21 and miRNA -215 in serum was analysed retrospectively using singleplex TaqMan two-step stem-loop quantitative real-time reverse-transcription PCR in 40 patients with HCC, 40 with chronic hepatitis C virus (HCV) with cirrhosis and 40 apparently healthy controls. +circulation_biomarker_diagnosis_down 34343125 hsa-mir-21 Carcinoma, Hepatocellular METHODOLOGY The gene expression of mature miRNA -21 and miRNA -215 in serum was analysed retrospectively using singleplex TaqMan two-step stem-loop quantitative real-time reverse-transcription PCR in 40 patients with HCC, 40 with chronic hepatitis C virus (HCV) with cirrhosis and 40 apparently healthy controls. +other 34343008 hsa-mir-205 Nasopharyngeal Neoplasms Since microRNA-205 (miRNA-205) is a predictive biomarker for antiradiation of nasopharyngeal carcinoma (NPC), quantitative detection of miRNA-205 is important for developing personalized strategies for the treatment of NPC. This method has great clinical application potential in the determination of miRNA-205, a biomarker for radiation-resistant NPC. +other 34342761 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck MATERIALS AND METHODS: The expression of miR-21, miR-31, miR-134, miR-146a, and miR-211 in swabbed samples from 36 dysplastic or hyperplastic OPMDs and 10 OSCCs, relative to respective normal mucosa within the same patient, is analyzed with qRT-PCR to develop a diagnosis. +other 34342761 hsa-mir-211 Squamous Cell Carcinoma of Head and Neck MATERIALS AND METHODS: The expression of miR-21, miR-31, miR-134, miR-146a, and miR-211 in swabbed samples from 36 dysplastic or hyperplastic OPMDs and 10 OSCCs, relative to respective normal mucosa within the same patient, is analyzed with qRT-PCR to develop a diagnosis. +other 34342761 hsa-mir-134 Squamous Cell Carcinoma of Head and Neck MATERIALS AND METHODS: The expression of miR-21, miR-31, miR-134, miR-146a, and miR-211 in swabbed samples from 36 dysplastic or hyperplastic OPMDs and 10 OSCCs, relative to respective normal mucosa within the same patient, is analyzed with qRT-PCR to develop a diagnosis. +other 34342761 hsa-mir-1 Squamous Cell Carcinoma of Head and Neck CLINICAL RELEVANCE: This conventional and convenient sampling tool, when coupled with an assessment of miR-31 expression, would seem to be an adjuvant approach to the diagnosis of OPMD and OSCC. +other 34342761 hsa-mir-146a Squamous Cell Carcinoma of Head and Neck MATERIALS AND METHODS: The expression of miR-21, miR-31, miR-134, miR-146a, and miR-211 in swabbed samples from 36 dysplastic or hyperplastic OPMDs and 10 OSCCs, relative to respective normal mucosa within the same patient, is analyzed with qRT-PCR to develop a diagnosis. +genetics_GWAS 34342374 hsa-mir-145 Carcinoma, Non-Small-Cell Lung The epigenetic signaling pathway of LINC00852/hsa-miR +transcription factor target 34341761 hsa-mir-4451 Dementia, Vascular We also found that miR-4451 regulates the PI16 expression, which may be a key target and biomarker for hernia pathogenesis and dementia crosstalk. +transcription factor target 34341761 hsa-mir-4451 Hernia We also found that miR-4451 regulates the PI16 expression, which may be a key target and biomarker for hernia pathogenesis and dementia crosstalk. +genetics_GWAS 34341435 hsa-mir-451a Cardiovascular Diseases 5p and microRNA-451 as useful epigenetic biomarkers to assess cardiovascular disease risk in patients with rheumatoid arthritis. +genetics_GWAS 34341435 hsa-mir-451 Cardiovascular Diseases 5p and microRNA-451 as useful epigenetic biomarkers to assess cardiovascular disease risk in patients with rheumatoid arthritis. +genetics_GWAS 34341435 hsa-mir-451 Arthritis, Rheumatoid 5p and microRNA-451 as useful epigenetic biomarkers to assess cardiovascular disease risk in patients with rheumatoid arthritis. +genetics_GWAS 34341435 hsa-mir-451a Arthritis, Rheumatoid 5p and microRNA-451 as useful epigenetic biomarkers to assess cardiovascular disease risk in patients with rheumatoid arthritis. +other 34341387 hsa-mir-371 Testicular Neoplasms Especially for the seminomas CS1, the high sensitivity of miR371 in detecting TGCC cells may have clinical implications. +other 34341387 hsa-mir-371a Testicular Neoplasms Especially for the seminomas CS1, the high sensitivity of miR371 in detecting TGCC cells may have clinical implications. +lncRNA target 34341185 hsa-mir-361 Carcinoma, Hepatocellular 5p attenuated the influence of lncRNA SBF2-AS1 downregulation on the viability, proliferation, and migration capability of HCC cells. +transcription factor target 34341171 hsa-mir-21 Leishmaniasis, Visceral miR-21 could therefore be used as a potential target for developing host-directed treatment for VL. +transcription factor target 34341171 hsa-mir-21 Leishmaniasis miR-21 could therefore be used as a potential target for developing host-directed treatment for VL. +lncRNA target 34340705 hsa-mir-138-1 Carcinoma, Hepatocellular 1-3p and PAK5 and the molecular mechanisms of PAK5-mediated sorafenib resistance in HCC, which provided a potential therapeutic target in advanced HCC patients. +exosome 34340698 hsa-mir-144 Fractures, Bone CONCLUSIONS: The results demonstrated an important role of exosomal miR5p in bone regeneration, offering insight into developing new strategy for the improvement of fracture healing in patients with diabetes mellitus. +exosome 34340698 hsa-mir-144 Diabetes Mellitus, Type 2 CONCLUSIONS: The results demonstrated an important role of exosomal miR5p in bone regeneration, offering insight into developing new strategy for the improvement of fracture healing in patients with diabetes mellitus. +circulation_biomarker_prognosis_ns 34340677 hsa-mir-211 Atherosclerosis CONCLUSION: Serum miR +lncRNA target 34340571 hsa-mir-34b Cardiomyopathies ZFAS1 alleviated inflammatory response and cell apoptosis in LPS-stimulated H9C2 cells via the miR-34b-5p/SIRT1 axis, providing novel potential therapeutic targets for SIC. +lncRNA target 34340571 hsa-mir-34b Sepsis ZFAS1 alleviated inflammatory response and cell apoptosis in LPS-stimulated H9C2 cells via the miR-34b-5p/SIRT1 axis, providing novel potential therapeutic targets for SIC. +lncRNA target 34340259 hsa-mir-506 Carcinoma, Hepatocellular CONCLUSION: Hsa_circ_0016788 facilitates the development of HCC through increasing PARP14 expression by regulating miR +other 34339965 hsa-mir-423 Spinal Cord Injuries 5p expression was decreased significantly after SCI in vivo and in vitro. +lncRNA target 34339961 hsa-mir-132 Acute Kidney Injury Therefore, targeting miR +transcription factor target 34339855 hsa-mir-182 Colorectal Neoplasms 5p mediated Tiam1/Rac1/p38 MAPK signaling pathway, implying potential novel therapeutic targets for CRC patients. +circulation_biomarker_diagnosis_ns 34339758 hsa-mir-663 Pulmonary Arterial Hypertension In contrast, circulating level of miR-663 dramatically reduced in PAH patients. +lncRNA target 34339707 hsa-mir-15a Myocardial Infarction, Acute Mechanistically, silencing transcription factor early growth response-1 (Egr-1) inhibited the level of miR-15a-5p, increased the protein expression of GPX4, accompanied by reduced ferroptosis and alleviated myocardial injury. +transcription factor target 34339487 hsa-mir-219 Breast Neoplasms 5p suppressed EMT and cell migration and invasion in breast cancer cells. +target gene 34339285 hsa-mir-186 Carcinoma, Non-Small-Cell Lung Circular RNAcirc_0076305 Promotes Cisplatin (DDP) Resistance of Non-Small Cell Lung Cancer Cells by Regulating ABCC1 Through miR-186-5p. +genetics_overexpression_suppress 34338998 hsa-mir-96 Adenocarcinoma of Lung 5p was overexpressed, which fostered LUAD cell proliferation, migration, and invasion. +genetics_overexpression_suppress 34338995 hsa-mir-195 Ovarian Neoplasms In addition, overexpression of miR +genetics_knock down_promote 34338972 hsa-mir-122 Ischemic Stroke Knockdown of Gm11974 attenuated neuronal injury in ischaemic stroke by regulating miR +genetics_knock down_suppress 34338955 hsa-mir-142 Acute Lung Injury MIR3142HG knockdown protected against ALI induced by LPS through alleviating the apoptosis and inflammation of HPMECs. +genetics_knock down_promote 34338434 hsa-mir-206 Femur Head Necrosis Knockdown of HIF-1 reversed the recovery effect of miR-206 inhibitor on SONFH cell model. +other 34338363 hsa-mir-4329 Myocardial Infarction, Acute The expression of miR6718 and miR-4329 in patients with myocardial infarction was significantly lower than that in normal controls. +other 34338363 hsa-mir-6718 Myocardial Infarction, Acute The expression of miR6718 and miR-4329 in patients with myocardial infarction was significantly lower than that in normal controls. +circulation_biomarker_diagnosis_up 34338285 hsa-mir-206 facioscapulohumeral muscular dystrophy 1 5p and miR-206 as new potential regulators of muscle pathology and miR-206 as a potential circulating biomarker for FSHD. +lncRNA target 34338153 hsa-mir-409 Pancreatic Carcinoma miR-409 is a tumor suppressor of PC, the clinical significance of miR-409 in pancreatic cancer and related tumor cell function was clarified. +lncRNA target 34338152 hsa-mir-200a Schistosomiasis Our study demonstrated that upregulation of miR-200a might contribute to inhibiting schistosomiasis liver fibrosis. +lncRNA target 34338152 hsa-mir-200a Liver Cirrhosis Our study demonstrated that upregulation of miR-200a might contribute to inhibiting schistosomiasis liver fibrosis. +lncRNA target 34338146 hsa-mir-101 Prostatic Neoplasms 3P suppressed PCA progression via aiming for CUL4B, which may offer the new molecular target for PCA clinical treatment. +transcription factor target 34338136 hsa-mir-216b Endometrial Neoplasms Additionally, hsa-mir-216b, hsa-mir-363, hsa-mir-940 and hsa-mir-1301 were highly expressed in EC tissues in contrast to normal tissues through qRT-PCR. +transcription factor target 34338136 hsa-mir-940 Endometrial Neoplasms Additionally, hsa-mir-216b, hsa-mir-363, hsa-mir-940 and hsa-mir-1301 were highly expressed in EC tissues in contrast to normal tissues through qRT-PCR. +transcription factor target 34338136 hsa-mir-1301 Endometrial Neoplasms Additionally, hsa-mir-216b, hsa-mir-363, hsa-mir-940 and hsa-mir-1301 were highly expressed in EC tissues in contrast to normal tissues through qRT-PCR. +transcription factor target 34338136 hsa-mir-363 Endometrial Neoplasms Additionally, hsa-mir-216b, hsa-mir-363, hsa-mir-940 and hsa-mir-1301 were highly expressed in EC tissues in contrast to normal tissues through qRT-PCR. +lncRNA target 34338087 hsa-mir-766 Norrie disease The differentially expression of miR-766 and VCAM1 in DN patients was reversed by actoeside. CONCLUSIONS: Actoeside promoted the growth and repressed the apoptosis and inflammation of HK-2 cells via miR-766/VCAM1/NF-kappaB signalling pathway, affording a promising idea for the treatment of DN. +other 34337881 hsa-mir-210 Ischemic Stroke At the end of the seven-day treatment, the area of cerebral infarction, the expression changes of miRNA-210 and ephrin A3 were determined. +genetics_overexpression_promote 34337864 hsa-mir-15a Carcinoma, Renal Cell In addition, overexpression of BTG2 could reverse the promotive effects of miR-15a on ccRCC. +genetics_knock down_promote 34337862 hsa-mir-125b Stomach Neoplasms Loss-of-function assays showed that miR-125b-5p suppression inhibited the proliferative and invasive abilities of gastric cancer cells. +other 34337857 hsa-mir-21 Adenocarcinoma of Lung These results provide evidence that the lncRNA CASC2/miR-21/p53 form a positive feedback loop to mediate cell proliferation and apoptosis in LUAD, which may provide a new insight into the pathological mechanisms of LUAD. +other 34337826 hsa-mir-1275 Squamous Cell Carcinoma of Head and Neck phosphate dehydrogenase 1 like interaction pairs may play a central role in LSCC. +other 34337826 hsa-mir-1246 Squamous Cell Carcinoma of Head and Neck phosphate dehydrogenase 1 like interaction pairs may play a central role in LSCC. +circulation_biomarker_diagnosis_up 34337736 hsa-mir-130b Thrombocytopenia Via proteomic analysis and RNA sequencing on plasma-derived exosomes from ITP patients and healthy controls, we found one upregulated exosomal protein (apolipoprotein E, ApoE), six downregulated exosomal miRNAs (miR +circulation_biomarker_diagnosis_up 34337736 hsa-mir-4433a Thrombocytopenia Via proteomic analysis and RNA sequencing on plasma-derived exosomes from ITP patients and healthy controls, we found one upregulated exosomal protein (apolipoprotein E, ApoE), six downregulated exosomal miRNAs (miR +circulation_biomarker_diagnosis_up 34337736 hsa-mir-584 Thrombocytopenia Via proteomic analysis and RNA sequencing on plasma-derived exosomes from ITP patients and healthy controls, we found one upregulated exosomal protein (apolipoprotein E, ApoE), six downregulated exosomal miRNAs (miR +circulation_biomarker_diagnosis_up 34337736 hsa-mir-501 Thrombocytopenia Via proteomic analysis and RNA sequencing on plasma-derived exosomes from ITP patients and healthy controls, we found one upregulated exosomal protein (apolipoprotein E, ApoE), six downregulated exosomal miRNAs (miR +circulation_biomarker_diagnosis_up 34337736 hsa-mir-142 Thrombocytopenia Via proteomic analysis and RNA sequencing on plasma-derived exosomes from ITP patients and healthy controls, we found one upregulated exosomal protein (apolipoprotein E, ApoE), six downregulated exosomal miRNAs (miR +circulation_biomarker_diagnosis_up 34337736 hsa-mir-29a Thrombocytopenia Via proteomic analysis and RNA sequencing on plasma-derived exosomes from ITP patients and healthy controls, we found one upregulated exosomal protein (apolipoprotein E, ApoE), six downregulated exosomal miRNAs (miR +circulation_biomarker_diagnosis_up 34337736 hsa-mir-16-2 Thrombocytopenia Via proteomic analysis and RNA sequencing on plasma-derived exosomes from ITP patients and healthy controls, we found one upregulated exosomal protein (apolipoprotein E, ApoE), six downregulated exosomal miRNAs (miR +circulation_biomarker_diagnosis_up 34337736 hsa-mir-363 Thrombocytopenia Via proteomic analysis and RNA sequencing on plasma-derived exosomes from ITP patients and healthy controls, we found one upregulated exosomal protein (apolipoprotein E, ApoE), six downregulated exosomal miRNAs (miR +circulation_biomarker_diagnosis_up 34337736 hsa-mir-29b Thrombocytopenia Via proteomic analysis and RNA sequencing on plasma-derived exosomes from ITP patients and healthy controls, we found one upregulated exosomal protein (apolipoprotein E, ApoE), six downregulated exosomal miRNAs (miR +circulation_biomarker_diagnosis_up 34337736 hsa-mir-4433b Thrombocytopenia Via proteomic analysis and RNA sequencing on plasma-derived exosomes from ITP patients and healthy controls, we found one upregulated exosomal protein (apolipoprotein E, ApoE), six downregulated exosomal miRNAs (miR +circulation_biomarker_diagnosis_up 34337736 hsa-mir-222 Thrombocytopenia Via proteomic analysis and RNA sequencing on plasma-derived exosomes from ITP patients and healthy controls, we found one upregulated exosomal protein (apolipoprotein E, ApoE), six downregulated exosomal miRNAs (miR +lncRNA target 34337719 hsa-mir-22 Enterocolitis, Necrotizing Silencing IRF5 or over-expressing miR3p relieved the role of lncRNA ENO1-IT1 on inflammation in NEC via CD206 and CD86 expression. +genetics_knock down_suppress 34337714 hsa-mir-24 Prostatic Neoplasms 3p or knockdown of JPT1 could partially reverse the effects of HOXA11-AS overexpression on PCa cell behaviors. +other 34337713 hsa-mir-1205 Colorectal Neoplasms CONCLUSIONS: In sum, our study demonstrated that ELFN1-AS1 sponges miR-1205 to upregulate MTA1, which is essential for CRC cell proliferation, migration, and invasion as well as apoptosis induction. +genetics_overexpression_promote 34337085 hsa-mir-100 Carcinoma, Hepatocellular Overexpression of miR-100 attenuates the invasive and proliferative abilities of hepatocellular carcinoma cells by targeting CXCR7. +lncRNA target 34337058 hsa-mir-186 Cholangiocarcinoma Overall, these results demonstrated that the lncRNA PVT1/miR186/KLF5 axis might exert a key role in the occurrence and progression of CCA, and this axis might provide a new target for treating CCA. +other 34337040 hsa-mir-145 Colonic Neoplasms 5p, lowly expressed in CC, were analyzed in the follow-up study. +other 34337040 hsa-mir-30 Colonic Neoplasms 5p, lowly expressed in CC, were analyzed in the follow-up study. +other 34337017 hsa-mir-142 Syphilis, secondary And in the blue module, the expression of miR3p was significantly higher in secondary syphilis patients than in healthy controls (p = 0.02), which is also close to the clinical features of secondary syphilis. +exosome 34336922 hsa-mir-221 Respiratory Distress Syndrome By quantitative RT-PCR, we validated the alteration of nine exosomal miRNAs in an independent cohort of 15 ARDS patients and 20 HSs, among which seven present high capability in discriminating ARDS patients from HSs (area under the curve > 0.8) (miR-130a-3p, miR +exosome 34336922 hsa-let-7d Respiratory Distress Syndrome By quantitative RT-PCR, we validated the alteration of nine exosomal miRNAs in an independent cohort of 15 ARDS patients and 20 HSs, among which seven present high capability in discriminating ARDS patients from HSs (area under the curve > 0.8) (miR-130a-3p, miR +exosome 34336922 hsa-mir-24 Respiratory Distress Syndrome By quantitative RT-PCR, we validated the alteration of nine exosomal miRNAs in an independent cohort of 15 ARDS patients and 20 HSs, among which seven present high capability in discriminating ARDS patients from HSs (area under the curve > 0.8) (miR-130a-3p, miR +exosome 34336922 hsa-mir-193a Respiratory Distress Syndrome By quantitative RT-PCR, we validated the alteration of nine exosomal miRNAs in an independent cohort of 15 ARDS patients and 20 HSs, among which seven present high capability in discriminating ARDS patients from HSs (area under the curve > 0.8) (miR-130a-3p, miR +exosome 34336922 hsa-mir-98 Respiratory Distress Syndrome By quantitative RT-PCR, we validated the alteration of nine exosomal miRNAs in an independent cohort of 15 ARDS patients and 20 HSs, among which seven present high capability in discriminating ARDS patients from HSs (area under the curve > 0.8) (miR-130a-3p, miR +exosome 34336922 hsa-mir-130a Respiratory Distress Syndrome By quantitative RT-PCR, we validated the alteration of nine exosomal miRNAs in an independent cohort of 15 ARDS patients and 20 HSs, among which seven present high capability in discriminating ARDS patients from HSs (area under the curve > 0.8) (miR-130a-3p, miR +exosome 34336922 hsa-mir-1273a Respiratory Distress Syndrome By quantitative RT-PCR, we validated the alteration of nine exosomal miRNAs in an independent cohort of 15 ARDS patients and 20 HSs, among which seven present high capability in discriminating ARDS patients from HSs (area under the curve > 0.8) (miR-130a-3p, miR +genetics_overexpression_promote 34336838 hsa-mir-545 Esophageal Squamous Cell Carcinoma Rescue experiments revealed that overexpression of MT1M largely restores miR +virus_miRNA 34336826 ebv-mir-BART12 Nasopharyngeal Carcinoma This miRNA is a member of one 6-miRNA Prognostic Signature in Nasopharyngeal Carcinoma +genetics_knock down_suppress 34336825 hsa-mir-21 Laryngeal Neoplasms CONCLUSION: Knockdown of circ_PVT1 prevented LC progression via targeting miR +lncRNA target 34336706 hsa-mir-20b Carcinoma, Renal Cell Moreover, miR-20b-5p was identified as a potential miRNA target of CTLA4 in KIRC. CONCLUSION: Our study clarified the prognostic value of several immune checkpoint regulators in KIRC, revealing a CTLA4/miR-20b-5p axis in the control of immune cell infiltration in the tumor microenvironment. +circulation_biomarker_diagnosis_up 34336682 hsa-mir-130b Stomach Neoplasms For GC patients, there were three up-regulated DEmiRNAs (hsa-miR-130b-3p, hsa-miR-151a-3p and hsa-miR-15b-3p) in the serum exosomes, and one up-regulated DEmiRNA (hsa-miR-1246) in the urinary exosomes. Four key exosomal miRNAs (hsa-miR-130b-3p, hsa-miR-151a-3p and hsa-miR-15b-3p) and the interaction network or enrichments based on their targets (TAOK1, CMTM6, SCN3A, WASF3, IGF1, CNOT7, GABRG1, PRKD1) may provide a reference of the molecular mechanisms in the GC development. +circulation_biomarker_diagnosis_up 34336682 hsa-mir-151a Stomach Neoplasms For GC patients, there were three up-regulated DEmiRNAs (hsa-miR-130b-3p, hsa-miR-151a-3p and hsa-miR-15b-3p) in the serum exosomes, and one up-regulated DEmiRNA (hsa-miR-1246) in the urinary exosomes. Four key exosomal miRNAs (hsa-miR-130b-3p, hsa-miR-151a-3p and hsa-miR-15b-3p) and the interaction network or enrichments based on their targets (TAOK1, CMTM6, SCN3A, WASF3, IGF1, CNOT7, GABRG1, PRKD1) may provide a reference of the molecular mechanisms in the GC development. +circulation_biomarker_diagnosis_up 34336682 hsa-mir-15b Stomach Neoplasms For GC patients, there were three up-regulated DEmiRNAs (hsa-miR-130b-3p, hsa-miR-151a-3p and hsa-miR-15b-3p) in the serum exosomes, and one up-regulated DEmiRNA (hsa-miR-1246) in the urinary exosomes. Four key exosomal miRNAs (hsa-miR-130b-3p, hsa-miR-151a-3p and hsa-miR-15b-3p) and the interaction network or enrichments based on their targets (TAOK1, CMTM6, SCN3A, WASF3, IGF1, CNOT7, GABRG1, PRKD1) may provide a reference of the molecular mechanisms in the GC development. +other 34336642 hsa-mir-214 Carcinoma, Hepatocellular In conclusion, we found that a novel lncRNA SNHG3/miR3p/ASF1B axis could promote the recurrence of HCC by regulating immune infiltration. +lncRNA target 34336268 hsa-mir-10a Carotid Artery Diseases Moreover, GATA6/VCAM-1 (a downstream target of miR-10a) was highly expressed in the endothelium, accompanied by the reduced levels of miR-10a during the development of human atherosclerosis. +genetics_overexpression_promote 34336153 hsa-mir-130 Carcinoma, Hepatocellular 3p overexpression considerably facilitates apoptosis and suppresses the migration or proliferation of HCC cells. +circulation_biomarker_diagnosis_ns 34336102 hsa-mir-23b Ovarian Neoplasms Therefore, we highlight that the LINC00909/miR-23b-3p/MRC2 axis is implicated in the pathogenesis of ovarian cancer, and serum LINC00909 may be a promising biomarker for the diagnosis of OC. +target gene 34336032 hsa-mir-107 Leukemia, Myeloid, Acute MicroRNA-107 promotes apoptosis of acute myelocytic leukemia cells by targeting RAD51. +genetics_knock down_promote 34336031 hsa-mir-130b Urinary Bladder Neoplasms CONCLUSIONS: High expression of miR-130b is negatively related to doxorubicin sensitivity in BUC, and knockdown of miR-130b improves doxorubicin sensitivity in BUC by negatively regulating CYLD expression. +target gene 34336030 hsa-mir-144 Carcinoma, Non-Small-Cell Lung MicroRNA 144 inhibits cell migration and invasion and regulates inflammatory cytokine secretion through targeting toll like receptor 2 in non-small cell lung cancer. +other 34336002 hsa-mir-487a Squamous Cell Carcinoma of Head and Neck CONCLUSION: Our study highlighted the significance of the TSPEAR-AS2/miR-487a-3p/PPM1A axis within OSCC progression and offered a novel biomarker and novel strategies for OSCC treatments. +genetics_overexpression_promote 34335967 hsa-mir-185 Hyperglycemia In contrast, overexpression of miR +transcription factor target 34335967 hsa-mir-185 Diabetes Mellitus Furthermore, metformin, an anti-diabetic drug, could upregulate miR5p expression to suppress G6Pase, leading to hepatic gluconeogenesis inhibition. +lncRNA target 34335948 hsa-mir-627 Carcinoma, Hepatocellular 5p suppresses HCC progression via targeting BCL3/CCND1 pathway. +lncRNA target 34335946 hsa-mir-133 Squamous Cell Carcinoma of Head and Neck Taken together, our mammal-to-Drosophila-to-mammal approach successfully validates targeting of PDE1C by miR-133 both in vivo and in vitro, underlying the promoted EMT phenotypes and potentially influencing the prognosis of oral cancer patients. +transcription factor target 34335939 hsa-mir-187 Squamous Cell Carcinoma of Head and Neck 3p enhanced migration and invasion by targeting PER2 in HNSCCs. +circulation_biomarker_diagnosis_up 34335917 hsa-mir-155 Macular Edema 5p was highly expressed in the aqueous humor (AH) and plasma of patients with DME compared with that in patients with MH, and this was even higher in the refractory DME group. +transcription factor target 34335907 hsa-mir-103 ankylosing spondylitis 1 A dual-luciferase assay verified that miR-103 binds to the 3'-untranslated region end of Rock1 mRNA, thus negatively regulating the activity of Rock1 and affecting pathological ossification during AS. Furthermore, tail suspension could inhibit the activation of mechanical kinase ROCK1 and p-Erk1/2 in the MAPK signaling pathway by upregulating miR-103, thereby inhibiting the classical osteogenesis-related Wnt/beta-catenin pathway in AS. +other 34335906 hsa-mir-223 Sepsis Thus, it was demonstrated that miR-223 negatively regulated the expression of IL-6, mediating the TLR4/NF-kappaB signaling pathway and exerting an anti-inflammatory effect in sepsis-induced lung injury. +other 34335906 hsa-mir-223 Lung Injury Thus, it was demonstrated that miR-223 negatively regulated the expression of IL-6, mediating the TLR4/NF-kappaB signaling pathway and exerting an anti-inflammatory effect in sepsis-induced lung injury. +target gene 34335889 hsa-mir-143 Urinary Bladder Neoplasms Long non-coding RNA PCAT6 regulates bladder cancer progression via the microRNA-143-3p/PDIA6 axis. +genetics_overexpression_suppress 34335864 hsa-mir-182 Adenocarcinoma of Lung Overexpression of miR +other 34335801 hsa-mir-27b Adenocarcinoma of Lung Microarrays and micro-RNA sequencing data suggested that there is a higher level of miR-27b and miR-92a in LUAD tissues than in non-LUAD tissues. In conclusion, mangiferin likely regulates proliferation and apoptosis in LUAD cells by reducing the expression levels of miR-92a and miR-27b. +other 34335801 hsa-mir-92a Adenocarcinoma of Lung Microarrays and micro-RNA sequencing data suggested that there is a higher level of miR-27b and miR-92a in LUAD tissues than in non-LUAD tissues. In conclusion, mangiferin likely regulates proliferation and apoptosis in LUAD cells by reducing the expression levels of miR-92a and miR-27b. +genetics_knock down_suppress 34335760 hsa-mir-195 Colorectal Neoplasms CONCLUSIONS: AFAP1-AS1 knockdown may inhibit the proliferation, migration, and invasion of CRC cells through the miR +lncRNA target 34335757 hsa-mir-378c Colorectal Neoplasms Then, ENCORI database (http://starbase.sysu.edu.cn/) was employed to predict that miR-378c was downregulated dramatically in CRC and E2F7 was the direct target of miR-378c. QRT-PCR (quantitative real-time polymerase chain reaction) was conducted to verify that the expression level of miR-378c was decreased while E2F7 expression was upregulated in CRC tissues compared with para-carcinoma tissues. +other 34335755 hsa-mir-493 Stomach Neoplasms 5p to upregulate MAP3K2 expression. +target gene 34335753 hsa-mir-193a Stomach Neoplasms miR-193a Directly Targets PSEN1 and Inhibits Gastric Cancer Cell Growth, the Activation of PI3K/Akt Signaling Pathway, and the Epithelial-to-Mesenchymal Transition. +lncRNA target 34335751 hsa-mir-489 Squamous Cell Carcinoma of Head and Neck CONCLUSION: Metformin inhibits HSCC progression through the circ_0003214/miR3p/ADAM10 pathway. +other 34335565 hsa-mir-146a Lupus Erythematosus, Systemic The miRNA-mRNA network showed that hsa-miR-146a might regulate the shared IFN-induced genes, which might play an important role in PAH secondary to SLE. +other 34335565 hsa-mir-146a Pulmonary Arterial Hypertension The miRNA-mRNA network showed that hsa-miR-146a might regulate the shared IFN-induced genes, which might play an important role in PAH secondary to SLE. +genetics_knock down_promote 34334630 hsa-mir-27b Uterine Cervical Neoplasms In the mechanism study, miR-27b-3p/VEGF-C signaling was demonstrated to be a key downstream of AFAP1-AS1 in the CD44v6(+) CC cells. CONCLUSIONS: LncRNA AFAP1-AS1 knockdown inhibits the CC cell stemness by upregulating miR-27b-3p to suppress VEGF-C. +genetics_overexpression_promote 34334583 hsa-mir-185 Cardiomyopathies Overexpression of miR-3185 inhibited the upregulation of Col I and Col III induced by TGF-beta1.MHRT promoted cardiac fibrosis after MI through miR-3185 and increased myocardial collagen deposition and promoted myocardial fibrosis. +genetics_overexpression_promote 34334583 hsa-mir-185 Myocardial Infarction Overexpression of miR-3185 inhibited the upregulation of Col I and Col III induced by TGF-beta1.MHRT promoted cardiac fibrosis after MI through miR-3185 and increased myocardial collagen deposition and promoted myocardial fibrosis. +transcription factor target 34334400 hsa-mir-96 Alzheimer Disease 5p in AD models could reduce Abeta42/Abeta40 ratios via upregulating the expression of ABCA1, indicating that miR +circulation_biomarker_prognosis_ns 34334379 hsa-mir-100 Uterine Cervical Neoplasms CONCLUSIONS: Serum miR-100 may be a useful diagnostic biomarker for CC, and for predicting lymph node metastasis and disease free survival in CC patients. +genetics_knock down_promote 34334103 hsa-mir-2355 Adenocarcinoma of Lung Knockdown of miR +lncRNA target 34334080 hsa-mir-24 Nerve Degeneration In conclusion, our work demonstrated that Dex improved OGD/R-induced neurological injury via SNHG11/miR3p/VEGFA axis. +other 34333815 hsa-mir-451a Mouth Neoplasms MiR-144 and miR-451a are deregulated in various cancers but the combined regulatory role of miR-144/451a cluster in oral squamous cell carcinoma (OSCC) remains unexplored. +lncRNA target 34333815 hsa-mir-144 Mouth Neoplasms CONCLUSION: miR-144/451a cluster functions as a tumor suppressor in OSCC by inhibiting cancer cell invasion, migration, and clonogenic potential. +lncRNA target 34333213 hsa-mir-4731 Nasopharyngeal Carcinoma CONCLUSIONS: Long noncoding RNA ANCR suppresses malignant behaviors of nasopharyngeal carcinoma cells by regulating miR5p/NMT1 axis. +circulation_biomarker_diagnosis_up 34333083 hsa-mir-150 Acute Kidney Injury 5p was down-regulated in the serum of patients with septic AKI (compared to healthy volunteers). +target gene 34332611 hsa-mir-146b Urinary Bladder Neoplasms Lnc-STYK1-2 regulates bladder cancer cell proliferation, migration, and invasion by targeting miR-146b-5p expression and AKT/STAT3/NF-kB signaling. +other 34332589 hsa-mir-223 Death, Sudden, Cardiac 3p, miR-499a-5p, and miR-133a-3p may serve as independent diagnostic biomarkers for SCD, and a combination of two of these miRNAs could further discriminate detailed causes of SCD. +other 34332589 hsa-mir-3113 Death, Sudden, Cardiac 3p, miR-499a-5p, and miR-133a-3p may serve as independent diagnostic biomarkers for SCD, and a combination of two of these miRNAs could further discriminate detailed causes of SCD. +other 34332589 hsa-mir-499a Death, Sudden, Cardiac 3p, miR-499a-5p, and miR-133a-3p may serve as independent diagnostic biomarkers for SCD, and a combination of two of these miRNAs could further discriminate detailed causes of SCD. +other 34332589 hsa-mir-133a Death, Sudden, Cardiac 3p, miR-499a-5p, and miR-133a-3p may serve as independent diagnostic biomarkers for SCD, and a combination of two of these miRNAs could further discriminate detailed causes of SCD. +exosome 34331784 hsa-mir-34c Lung Injury We found that rno-miR-34c-3p was downregulated in MSCs cocultured with ALI exosomes. In conclusion, ALI exosomes decrease the miR-34c-3p expression levels, influencing MSCs via the JAK1/STAT3 signaling pathway. +other 34331613 hsa-mir-149 Pulmonary Disease, Chronic Obstructive 5p may be a key factor in PM(2.5)-induced COPD. +other 34331612 hsa-mir-128 Multiple Myeloma 3p to increase PLAGL2 expression. +transcription factor target 34331478 hsa-mir-155 Atherosclerosis This study provides a fundamental insight on the miR-155 mechanism for PAHs enhancing atherosclerosis and miR-155 potentially serving as a novel drug target. +genetics_overexpression_promote 34331407 hsa-mir-140 Hypoxia-Ischemia, Brain The OGD-induced impaired cell viability, enhanced cell apoptosis, and activated neuroinflammation were abrogated by the overexpression of miR-140 in both PC12 and SH-SY5S cells. +circulation_biomarker_diagnosis_down 34331407 hsa-mir-410 Hypoxia-Ischemia, Brain CONCLUSION: All data revealed that serum downregulated miR-410 in HIE serves as candidate diagnostic biomarker, and that miR-410 exerts a neuroprotective role in OGD-injured cells by improving cell viability and inhibiting cell apoptosis through targeting PTEN. +tissue_expression_ns 34331175 hsa-mir-130 Inflammation In conclusion, we proved Se deficiency could induce the deregulation of miRCYLD axis to cause RIPK3-dependent necroptosis and inflammation in pig cerebellum. +tissue_expression_ns 34331175 hsa-mir-130 Necrosis In conclusion, we proved Se deficiency could induce the deregulation of miRCYLD axis to cause RIPK3-dependent necroptosis and inflammation in pig cerebellum. +other 34331128 hsa-mir-21 Carcinoma, Endometrioid In particular, in endometrioid carcinoma, high miR-21 expression in cancer cells was an independent prognostic factor associated with poor progression-free survival, as well as older age and higher International Federation of Gynecology and Obstetrics (FIGO) stage. +other 34330446 hsa-mir-362 Inflammatory Bowel Diseases We applied this platform successfully for miR-362, a potential biomarker of inflammatory bowel diseases (IBD), or HIV-related DNA (hDNA) detection, achieving the detection limits of 6.5 nM and 1.7 nM, respectively. +lncRNA target 34330309 hsa-mir-35 Polycystic Ovary Syndrome CONCLUSIONS: TMPO-AS1 might suppress miR5p maturation to participate in PCOS. +lncRNA target 34330307 hsa-mir-137 Rheumatic Fever CONCLUSION Circ_0025908 facilitates the development of RA through increasing HIPK2 expression by regulating miR-137, which also offered an underlying targeted therapy for RA treatment. +circulation_biomarker_diagnosis_up 34330158 hsa-mir-222 Acute Coronary Syndrome Circulating miR-221/222 may be novel biomarkers for the diagnosis of coronary artery stenosis >/=50% and the occurrence of ACS. +circulation_biomarker_diagnosis_up 34330158 hsa-mir-221 Acute Coronary Syndrome Circulating miR-221/222 may be novel biomarkers for the diagnosis of coronary artery stenosis >/=50% and the occurrence of ACS. +lncRNA target 34329919 hsa-mir-124 Glioblastoma This work indicated that our new polymeric nanoparticles successfully mediate inhibition of miR-21 and miR-124 supplementation to significantly reduce tumorigenesis, and may have strong potential in GBM therapy. +lncRNA target 34329919 hsa-mir-21 Glioblastoma This work indicated that our new polymeric nanoparticles successfully mediate inhibition of miR-21 and miR-124 supplementation to significantly reduce tumorigenesis, and may have strong potential in GBM therapy. +genetics_overexpression_promote 34329839 hsa-mir-1343 Colorectal Neoplasms 3p overexpression or PARP1 down-regulation affected the biological behaviors of CRC cells. +genetics_knock down_promote 34329837 hsa-mir-205 Liver Neoplasms Loss of CDKL3 impaired the malignant activities of liver cancer cells, and could even impair the pro-tumor effects of down-regulated exosomal miR +genetics_GWAS 34329686 hsa-mir-378a Muscular Dystrophy, Duchenne Increased levels of miR-378a were reported in the serum of Duchenne muscular dystrophy (DMD) patients and female carriers of DMD gene-associated mutations with developed cardiomyopathy. In order to shed more light on the role of miR-378a in human cardiomyocytes and its potential involvement in DMD-related cardiomyopathy, we generated two human induced pluripotent stem cell (hiPSC) models; one with deletion of miR-378a and the second one with deletion of DMD exon 50 leading to the DMD phenotype. +other 34329686 hsa-mir-378a Hypertrophy It was observed that miR-378a protects cardiomyocytes from hypertrophic growth by regulation of IGF1R and the expression of downstream kinases. miR-378a-deficient hiPSC-CM exhibited, however, significantly bigger size compared to the isogenic control cells, indicating the role of this miRNA in the hypertrophic growth of human cardiomyocytes. +genetics_GWAS 34329686 hsa-mir-378a Cardiomyopathies Increased levels of miR-378a were reported in the serum of Duchenne muscular dystrophy (DMD) patients and female carriers of DMD gene-associated mutations with developed cardiomyopathy. In order to shed more light on the role of miR-378a in human cardiomyocytes and its potential involvement in DMD-related cardiomyopathy, we generated two human induced pluripotent stem cell (hiPSC) models; one with deletion of miR-378a and the second one with deletion of DMD exon 50 leading to the DMD phenotype. +other 34329656 hsa-mir-155 Atherosclerosis 5p, were subjected to validation by RT-qPCR in normal arteries and also in pathological/atheroma counterparts, considering all the available 20 artery specimens. +other 34329475 hsa-mir-15a Lung Diseases Conclusion: SeMet could reduce the oxidative damage and activate NLRP3 inflammasome reaction by stimulating miR-15a/JNK, thus reduced the pulmonary necroptosis induced by LPS. +other 34329475 hsa-mir-15a Carcinoma, Hepatocellular To further study these mechanisms, we established a supplement of selenomethionine (SeMet) and/or LPS-treated chicken model and a cell model of LPS and/or high and low expression of miR-15a in chicken hepatocellular carcinoma (LMH) cells. +lncRNA target 34329471 hsa-mir-339 Breast Neoplasms In 157 paired breast cancer and adjacent normal samples, tumour suppressor gene GPER1 and miR-339 are both downregulated in Luminal A/B and Triple Negative Breast Cancer subtypes. Mechanistic investigations revealed that miR-339 upregulates GPER1 expression in breast cancer cells by switching on the GPER1 enhancer, which can be blocked by enhancer deletion through the CRISPR/Cas9 system. +other 34329340 hsa-mir-99a Esophageal Squamous Cell Carcinoma Survival univariate/multivariate COX analysis revealed that five genes, ZBTB16, AQP4, ADCYAP1R1, PDGFD, and VIPR2, and two microRNAs, miR-99a-5p, and miR5p, were related to esophageal cancer prognosis. +other 34329193 hsa-mir-370 Breast Neoplasms circFOXK2 could act with IGF2BP3, an RNA-binding protein, and miR-370 to synergistically promote BC metastasis. In conclusion, circFOXK2 functions as a key regulator in BC metastasis, and the role of circFOXK2 on BC metastasis is tightly associated with the involvement of IGF2BP3 and miR-370. +circulation_biomarker_diagnosis_ns 34328678 hsa-mir-126 Glioblastoma Furthermore, LINC00511 was mainly distributed in the cytoplasm of GBM cells and regulated Wnt/beta-catenin activation by acting as a molecular sponge for miR +lncRNA target 34328265 hsa-mir-4691 Liver Neoplasms CONCLUSIONS: We suggest that TPRG1-AS1 is a novel ceRNA sponging miR5p and miR-3659, resulting in RBM24 expression and suppression of liver cancer growth. +lncRNA target 34328198 hsa-mir-184 Prostatic Neoplasms On the whole, the findings of the present study suggest that SNHG11 expression is upregulated in PCa and that it facilitates PCa progression, at least in part, via the modulation of the miR184/IGF1R signaling axis. +lncRNA target 34328197 hsa-mir-29a Osteosarcoma In addition, H19 served as a competing endogenous ncRNA targeting microRNA29a3p and activating LIM and SH3 domain protein 1 and modulating the OS cell phenotype. +lncRNA target 34328196 hsa-mir-351 Acute Lung Injury In conclusion, the present study indicated that miR3515p aggravated LPSinduced ALI via inhibiting AMPK, suggesting that targeting miR3515p may help to develop efficient therapeutic approaches for treating ALI. +lncRNA target 34328193 hsa-mir-429 Adenocarcinoma of Lung In conclusion, interference of circPVT1 inhibits the progression of lung ADC and enhances its sensitivity to DDP via miR429/FOXK1, which may provide a theoretical basis for the use of novel targets in the treatment of lung ADC. +exosome 34327982 hsa-mir-10b Pancreatic Carcinoma Moreover, the biosensor was further used to detect exosomal miRNA-10b derived from pancreatic cancer cells and normal pancreatic cells. +genetics_overexpression_promote 34327529 hsa-mir-23a Breast Neoplasms Rescue experiments demonstrated that the restoration of miR-23a-3p in NEAT1-overexpressing Taxol-resistant breast cancer cells successfully overcame the NEAT1-promoted Taxol resistance. +transcription factor target 34327240 hsa-mir-214 Pituitary Diseases 3p could protect VECs from ROS-induced endothelial dysfunction by reversing its inhibitory effect on GPX4 expression. +other 34327234 hsa-mir-4435-2 Inflammatory Bowel Disease 11 lncRNA MIR4435-2HG is a variable in the decision tree for moderate-to-severe UC diagnostic prediction. +exosome 34326916 hsa-mir-218 Myocardial Infarction In summary, these results show that the protective ability of EPC-Exos against MI was mediated by the shuttled miR +exosome 34326916 hsa-mir-363 Myocardial Infarction In summary, these results show that the protective ability of EPC-Exos against MI was mediated by the shuttled miR +genetics_knock down_suppress 34326893 hsa-mir-144 Squamous Cell Carcinoma of Head and Neck In conclusion, our study confirmed the loss or downregulation of miR +genetics_knock down_promote 34326879 hsa-mir-129 Osteoporosis 5p/Dkk3 axis may be new potential targets for the treatment of bone defect and bone loss. +genetics_knock down_promote 34326879 hsa-mir-129 Bone Diseases 5p/Dkk3 axis may be new potential targets for the treatment of bone defect and bone loss. +other 34326714 hsa-mir-26a Bone Diseases We finally examined the efficacy of HA-SS-PGEA/miR-26a NPs loaded 3D hybrid nanofiber aerogels showing a positive effect on the cranial bone defect healing. +circulation_biomarker_prognosis_up 34326690 hsa-mir-214 Osteosarcoma 3p silence/over-expression with or without cantharidin treatment, and nuclear/cytoplasmic protein assay in osteosarcoma cells. +circulation_biomarker_diagnosis_up 34326666 hsa-mir-613 Triple Negative Breast Neoplasms RESULTS: TNBC patients receiving ADD adjuvant therapy after chemotherapy, with decreased serum level of hsa_circ_0001982 and increased serum level of miR-206/miR-613 as relative to non-ADD treatment group (P<0.05), were less likely to relapse than TNBC population not undergoing ADD treatment (P<0.05). +circulation_biomarker_diagnosis_up 34326666 hsa-mir-206 Triple Negative Breast Neoplasms RESULTS: TNBC patients receiving ADD adjuvant therapy after chemotherapy, with decreased serum level of hsa_circ_0001982 and increased serum level of miR-206/miR-613 as relative to non-ADD treatment group (P<0.05), were less likely to relapse than TNBC population not undergoing ADD treatment (P<0.05). +circRNA target 34326457 hsa-mir-340 Colorectal Neoplasms Our data indicated an oncogenic role of circN4BP2L2 in CRC via regulation of the miR5p/CXCR4 axis, which may be a promising biomarker and target for CRC treatment. +lncRNA target 34326275 hsa-mir-431 Uterine Cervical Neoplasms These results demonstrated that circSPIDR suppresses cervical adenocarcinoma by competitively binding to miR +other 34326064 hsa-mir-199a Spinal Cord Injuries MicroRNAs (miRs) have been implicated in regulation of PTEN and mTOR expression, and previous work in spinal cord showed an increase in miR-199a-3p after spinal cord injury (SCI) and increase in miR-21 in SCI animals that had undergone exercise. +other 34326064 hsa-mir-21 Spinal Cord Injuries MicroRNAs (miRs) have been implicated in regulation of PTEN and mTOR expression, and previous work in spinal cord showed an increase in miR-199a-3p after spinal cord injury (SCI) and increase in miR-21 in SCI animals that had undergone exercise. +genetics_overexpression_promote 34325604 hsa-mir-654 Arthritis, Rheumatoid Furthermore, FZD4 overexpression also reversed the effects of miR +lncRNA target 34325283 hsa-mir-26b Osteoarthritis induced OA progression via circ_SEC24A/miR-26b-5p/DNMT3A ceRNA axis. +lncRNA target 34325277 hsa-mir-26b Arthritis, Rheumatoid CONCLUSION: MiR-26b-5p may affect the biological characteristics of RA-FLS via targeting EZH2, including proliferation, apoptosis, invasion and migration, as well as the secretion of cytokines, thus playing a potential therapeutic role in RA. +other 34324865 hsa-mir-211 Reperfusion Injury, Cerebral Ischemia 5p and is then regulating the expression of COX-2. +transcription factor target 34324740 hsa-mir-148a Colorectal Neoplasms These results reveal that miR-148a-3p can function as a tumor promotor in CRC by targeting the CANX/MHC-I axis, which provides a rationale for immunotherapy through targeting the miR-148a-3p/CANX/MHC-I pathway in patients with CRC. +genetics_knock down_promote 34324278 hsa-mir-1296 Triple Negative Breast Neoplasms miR-1296 interacted with the 3' untranslated region (3'UTR) of ZFX, and ZFX overexpression partly reversed miR-1296 overexpression-mediated effects in TNBC cells. +lncRNA target 34324029 hsa-mir-153 Breast Neoplasms 3p was found to modulate breast cancer cell carcinogenesis via targeting CFL2. +lncRNA target 34323695 hsa-mir-486 Breast Neoplasms 5p and tamoxifen exhibit additive and synergistic tumor-suppressive effects, most importantly causing profound cell death specifically in tamoxifen-resistant BC cells. +transcription factor target 34323631 hsa-mir-670 Glioblastoma 3p can be an alternative, at least adjuvant strategy to treat glioblastoma. +lncRNA target 34323178 hsa-mir-101 Uterine Cervical Neoplasms Finally, the interaction between PTAR and miR-101 in uterine cancer was verified through a dual-luciferase reporter assay and correlation analysis. +lncRNA target 34323174 hsa-mir-142 Carcinoma, Non-Small-Cell Lung We confirmed that COX10-AS1 down-expression can restore the inhibitory effect of miR5p on PAICS, promote the apoptosis of NSCLC cells, and inhibit the proliferation of NSCLC cells. +genetics_knock down_promote 34323000 hsa-mir-16 Thyroid Neoplasms Collectively, circZFR knockdown retarded TC progression by sponging miR-16 and modulating MAPK1 expression. +lncRNA target 34322902 hsa-mir-21 psoriasis 1 BACKGROUND: Expression of microRNA-21 (miR-21) is increased in psoriasis, leading to reduced levels of epidermal tissue inhibitor of matrix metalloproteinase 3 (TIMP-3), a highly potent inhibitor of the tumor necrosis factor alpha (TNFalpha) sheddase TACE (TNFalpha-converting enzyme)/ADAM17. +lncRNA target 34322848 hsa-mir-338 Glioma 3p exerted profound inhibition effects on GBM cell growth in vitro or in vivo through targeting Prex2, leading to attenuation of (Protein kinase B) AKT/Signal transducer and activator of transcription 3 (STAT3) signaling activation. +other 34322788 hsa-mir-3164 Nasopharyngeal Carcinoma The LINC00324/miR-3164/PAD4 axis modulated the PI3K/AKT pathway in NPC cells. +genetics_knock down_suppress 34322757 hsa-mir-485 Colorectal Neoplasms Circ_0007031 knockdown repressed CRC malignant progression by reducing MELK expression through associating with miR +circulation_biomarker_diagnosis_ns 34322647 hsa-mir-200a Pituitary Neoplasms Our results depicted a miR-200a and lncRNA ANRIL expression in tissue and plasma samples in the patients with invasive PA. +other 34322490 hsa-mir-205 Ovarian Neoplasms HOTTIP-miR-205-ZEB2 Axis Confers Cisplatin Resistance to Ovarian Cancer Cells. +other 34322482 hsa-mir-494 Hyperglycemia Pharmacological ER stress inducers (tunicamycin (TCN) and thapsigargin) and hyperglycemia robustly increase the expression of miR-494 in vitro. +lncRNA target 34322386 hsa-mir-143 Carcinoma, Hepatocellular CONCLUSION: SOX2-OT inhibited the targeted inhibition of miR +circulation_biomarker_diagnosis_up 34321907 hsa-mir-365 Hypertension CONCLUSION: The miR-365 serum expression in patients with LVH-accompanied HT was increased compared with the observation group and the control group and positively correlated with the LVH degree. +circulation_biomarker_diagnosis_up 34321907 hsa-mir-365 Hypertrophy, Left Ventricular CONCLUSION: The miR-365 serum expression in patients with LVH-accompanied HT was increased compared with the observation group and the control group and positively correlated with the LVH degree. +circulation_biomarker_diagnosis_ns 34321587 hsa-mir-210 Sepsis Taken together, the key findings of the current study demonstrate that plasma EVs carrying miR +circulation_biomarker_diagnosis_ns 34321587 hsa-mir-210 Acute Lung Injury Taken together, the key findings of the current study demonstrate that plasma EVs carrying miR +genetics_GWAS 34321465 hsa-mir-361 Glioma Loss/gain-of-function method was applied to determine the roles of miR +exosome 34321461 hsa-mir-1260b Carcinoma, Non-Small-Cell Lung In conclusion, exosomal miR-1260b can promote angiogenesis in HUVECs and metastasis of NSCLC by regulating HIPK2 and may serve as a prognostic marker for lung cancers. +other 34321456 hsa-mir-526b Lung Neoplasms We found that miR-526b-3p expression declined while PD-L1 was elevated in cisplatin-resistant lung cancer compared to that in cisplatin-sensitive lung cancer by analyzing clinical samples. +other 34321402 hsa-mir-221 Atherosclerosis In conclusion, circSCAP facilitated lipid accumulation, inflammation, and oxidative stress in ox-LDL-induced THP-1 macrophages by regulating miR5p/PDE3B axis. +lncRNA target 34321385 hsa-mir-215 Heart Failure In conclusion, SOX2-OT aggravated heart failure in vivo and promoted H9c2 cell injury via the miR5p/ZEB2 axis in vitro, implying a novel insight into heart failure treatment. +genetics_knock down_promote 34321174 hsa-mir-195 Stomach Neoplasms In conclusion, our study suggested that IGF2-AS knockdown suppressed glycolysis and facilitated apoptosis in GC cells at least partly through sponging miR-195 and modulating CREB1 expression, highlighting a novel therapeutic strategy for GC treatment. +lncRNA target 34321149 hsa-mir-142 Breast Neoplasms 5p, which inhibits the expression of DNMT1 by targeting the 3-UTR of DNMT1, thereby forming a feedback loop and inhibiting the migration and proliferation of breast cancer. +other 34321097 hsa-mir-29c Diabetes Mellitus While micro RNA 29c was found to be significantly higher in participants with positive family history of type 2 diabetes as compared to those without family history of diabetes (P = 0.001). +lncRNA target 34321010 hsa-mir-194 Carcinoma, Non-Small-Cell Lung 5p bound to the 3' untranslated region (3'UTR) of HOOK3 mRNA for its inhibition. +transcription factor target 34320900 hsa-mir-20a Carcinoma, Squamous Cell, Cutaneous Crocin can target ATG2B/miR-320a and may be an effective alternative for cSCC treatment. +circulation_biomarker_prognosis_ns 34320871 hsa-mir-675 Atherosclerosis The clinical diagnostic significance of serum miR +lncRNA target 34320711 hsa-mir-22 Breast Neoplasms 3p could suppress the proliferation of breast cancer by targeting PLAGL2. +lncRNA target 34320692 hsa-mir-6717 Lung Neoplasms In particular, hsa_circ_0051488 binds to mir5p, thereby modulating the expression of SATB2 gene, a lung cancer suppressor. +other 34320692 hsa-mir-6717 Syphilis These findings suggest a possible regulatory mechanism of hsa_circ_0051488 in LUSC, and that the newly discovered hsa_circ_0051488/miR5p/SATB2 axis may be a potential route for therapeutic intervention of LUSC. +transcription factor target 34320373 hsa-mir-200c Diabetes Mellitus, Type 2 Collectively, these studies establish that miR-200c plays an important role in T2D, and small molecules targeting RNA structure can be an important complement to oligonucleotides. +circRNA target 34320370 hsa-mir-497 Colorectal Neoplasms RESULTS: The results showed that hsa_circ_0136666 and PD-L1 was increased in colorectal cancer cells while miR-497 was decreased in colorectal cancer cells when compared with normal colon epithelial cell line. CONCLUSIONS: Our findings demonstrated that hsa_circ_0136666 promoted the expression of PD-L1 by inhibiting miR-497 level in colorectal cancer, thus inducing the activation of Treg cells and leading to the immune escape of tumor, providing a novel mechanistic insight into the pathogenesis of colorectal cancer. +circRNA target 34320120 hsa-mir-106a Colorectal Neoplasms Together, these findings showed that circEGFR promoted CRC cell proliferation, migration, and invasion through the miR-106a-5p/DDX5/AKT axis, and may serve as a promising diagnostic marker and therapeutic target for CRC patients. +other 34320033 hsa-mir-223 Carcinoma, Ovarian Epithelial 3p) and 8 mRNAs (ATF3, CH25H, EMP1, HBB, HBEGF, NAMPT, POSTN, and PROCR) were identified and the findings appear to be well supported by the literature. +other 34320033 hsa-mir-486 Carcinoma, Ovarian Epithelial 3p) and 8 mRNAs (ATF3, CH25H, EMP1, HBB, HBEGF, NAMPT, POSTN, and PROCR) were identified and the findings appear to be well supported by the literature. +other 34320033 hsa-mir-27a Carcinoma, Ovarian Epithelial 3p) and 8 mRNAs (ATF3, CH25H, EMP1, HBB, HBEGF, NAMPT, POSTN, and PROCR) were identified and the findings appear to be well supported by the literature. +other 34320033 hsa-mir-506 Carcinoma, Ovarian Epithelial 3p) and 8 mRNAs (ATF3, CH25H, EMP1, HBB, HBEGF, NAMPT, POSTN, and PROCR) were identified and the findings appear to be well supported by the literature. +other 34320033 hsa-mir-126 Carcinoma, Ovarian Epithelial 3p) and 8 mRNAs (ATF3, CH25H, EMP1, HBB, HBEGF, NAMPT, POSTN, and PROCR) were identified and the findings appear to be well supported by the literature. +other 34320033 hsa-mir-23a Carcinoma, Ovarian Epithelial 3p) and 8 mRNAs (ATF3, CH25H, EMP1, HBB, HBEGF, NAMPT, POSTN, and PROCR) were identified and the findings appear to be well supported by the literature. +other 34320031 hsa-mir-423 COVID-19 5p) independently classified COVID-19 cases with an accuracy of 99.9%. +other 34320031 hsa-mir-23a COVID-19 5p) independently classified COVID-19 cases with an accuracy of 99.9%. +other 34320031 hsa-mir-195 COVID-19 5p) independently classified COVID-19 cases with an accuracy of 99.9%. +genetics_knock down_promote 34319909 hsa-mir-490 Prostatic Neoplasms 3p or up-regulation of FRAT1 reversed the suppressive effects of CCAT1 knockdown on the PCa cells. +transcription factor target 34319904 hsa-mir-17 congenital nongoitrous hypothyroidism 4 Using HTR-8/SVneo cells, we demonstrated that elevated TSH inhibited miR +other 34319904 hsa-mir-17 Sjogren's Syndrome Compared with normal pregnant women, miR5p was decreased and zinc finger protein 367 (ZNF367) was upregulated in the chorionic villi of TSH > 2.5 mIU/L-related SA patients. +circulation_biomarker_prognosis_ns 34319554 hsa-mir-590 Heart Failure, Chronic This study found that the serum levels of ZFAS1 were significantly higher, while miR +circulation_biomarker_diagnosis_ns 34319544 hsa-mir-23a Infertility, Male We assessed the potential role of proinflammatory cytokines (TNF-alpha, IL-6 and IL-1alpha) and microRNAs (miR-146a-5p, miR-34a-5p and miR-23a-3p) in the seminal plasma of infertile men compared to controls, evaluating their correlation with seminal and biochemical parameters. +circulation_biomarker_diagnosis_ns 34319544 hsa-mir-146a Infertility, Male We assessed the potential role of proinflammatory cytokines (TNF-alpha, IL-6 and IL-1alpha) and microRNAs (miR-146a-5p, miR-34a-5p and miR-23a-3p) in the seminal plasma of infertile men compared to controls, evaluating their correlation with seminal and biochemical parameters. +circulation_biomarker_diagnosis_ns 34319544 hsa-mir-34a Infertility, Male We assessed the potential role of proinflammatory cytokines (TNF-alpha, IL-6 and IL-1alpha) and microRNAs (miR-146a-5p, miR-34a-5p and miR-23a-3p) in the seminal plasma of infertile men compared to controls, evaluating their correlation with seminal and biochemical parameters. +other 34319204 hsa-mir-34a Ovarian Neoplasms MicroRNA-mediated gene therapy is emerging as a promising method for the treatment of ovarian cancer, but the development of miRNA mimic delivery vectors is still in its infancy, where the safety and efficacy of miR-34a-mimic remain unknown. In summary, UTMD-mediated miR-34a-mimic delivery has potential application in the clinical treatment of ovarian cancer. +target gene 34319136 hsa-mir-486 Osteoarthritis MicroRNA-486 promotes a more catabolic phenotype in chondrocyte-like cells by targeting SIRT6 : possible involvement in cartilage degradation in osteoarthritis. +lncRNA target 34319043 hsa-mir-15a Leukemia, Lymphocytic, Chronic, B-Cell CONCLUSIONS: Our data propose that suppression of Bcl-2 and Mcl-1 by miRNA-15a can effectively inhibit the cell proliferation and sensitize CLL cells to fludarabine. +circulation_biomarker_diagnosis_ns 34319042 hsa-mir-138 Squamous Cell Carcinoma of Head and Neck CONCLUSION: Our findings suggest that the evaluation of miR-138 and miR5p expression in serum can be used as potent markers for carcinoma detection and also may be a potentially therapeutic approach in the future. +circulation_biomarker_diagnosis_ns 34319042 hsa-mir-424 Squamous Cell Carcinoma of Head and Neck CONCLUSION: Our findings suggest that the evaluation of miR-138 and miR5p expression in serum can be used as potent markers for carcinoma detection and also may be a potentially therapeutic approach in the future. +circulation_biomarker_prognosis_ns 34318932 hsa-mir-22 Lymphoma, Large B-Cell, Diffuse Here we validated serum miR-22, an evolutionarily conserved microRNA, as a prognostic/predictive biomarker in DLBCL. These results suggest that miR-22 is a promising complementary or even independent non-invasive biomarker for DLBCL management. +circulation_biomarker_diagnosis_ns 34318873 hsa-mir-155 Pre-Eclampsia We investigated the expression of VEGF-related circulating miR-16, miR-29b, miR-126, miR-155 and miR-200c in PE vs healthy pregnancies (HPs), and their relation with vascular function, oxidative stress (OS) and systemic inflammation. +circulation_biomarker_diagnosis_ns 34318873 hsa-mir-29b Pre-Eclampsia We investigated the expression of VEGF-related circulating miR-16, miR-29b, miR-126, miR-155 and miR-200c in PE vs healthy pregnancies (HPs), and their relation with vascular function, oxidative stress (OS) and systemic inflammation. +circulation_biomarker_diagnosis_ns 34318873 hsa-mir-126 Pre-Eclampsia We investigated the expression of VEGF-related circulating miR-16, miR-29b, miR-126, miR-155 and miR-200c in PE vs healthy pregnancies (HPs), and their relation with vascular function, oxidative stress (OS) and systemic inflammation. +other 34318873 hsa-mir-16 Pre-Eclampsia Independent of age and parity, miR-16 was related to impaired FMD (beta 2.771, 95% C.I.: 0.023-5.519, P=0.048) and mFMD (beta 3.401, 95% C.I.: 0.201-6.602, P=0.038). +circulation_biomarker_diagnosis_ns 34318873 hsa-mir-200c Pre-Eclampsia Circulating miR-200c was increased in PE and correlated with higher arterial stiffness. +genetics_GWAS 34318684 hsa-mir-181b Autistic Disorder A few years ago, in a review we outlined the most common epigenetic alterations in major psychiatric disorders (e.g., aberrant DNA methylation of DTNBP1, HTR2A, RELN, MB-COMT and PPP3CC, and increased expression of miR-34a and miR-181b). +genetics_GWAS 34318684 hsa-mir-34a Autistic Disorder A few years ago, in a review we outlined the most common epigenetic alterations in major psychiatric disorders (e.g., aberrant DNA methylation of DTNBP1, HTR2A, RELN, MB-COMT and PPP3CC, and increased expression of miR-34a and miR-181b). +genetics_knock down_promote 34318683 hsa-mir-576 Stomach Neoplasms Overexpressing miR +lncRNA target 34318554 hsa-mir-34a Drug-Induced Kidney Injury In this study, the protective effect of betaine against cisplatin-induced nephrotoxicity through modulating the expression of microRNA 34a (miRNA 34a), p53, apoptosis, and inflammation was investigated. In conclusion, cisplatin-induced nephrotoxicity in rats was associated with upregulation of miRNA 34a expression, apoptosis, and inflammation in p53-dependent manner. +transcription factor target 34318435 hsa-mir-125b Prostatic Neoplasms 3p are potential therapeutic targets against prostate cancer. +transcription factor target 34318435 hsa-mir-221 Prostatic Neoplasms 3p are potential therapeutic targets against prostate cancer. +transcription factor target 34318435 hsa-mir-145 Prostatic Neoplasms 3p are potential therapeutic targets against prostate cancer. +genetics_overexpression_promote 34318428 hsa-mir-802 Osteosarcoma In addition, miR-802 overexpression inactivated PI3K/AKT pathway via targeting p27 in OS. +target gene 34316513 hsa-mir-338 Osteosarcoma Silencing of LINC00707 suppresses cell proliferation, migration, and invasion of osteosarcoma cells by modulating miR-338-3p/AHSA1 axis. +other 34316330 hsa-mir-203a Head and Neck Neoplasms We further refined these findings using a Random forest approach, and miR-203a-3p, mir-10a-5p, and miR5p to be most strongly associated with LVI. +other 34316330 hsa-mir-194 Head and Neck Neoplasms We further refined these findings using a Random forest approach, and miR-203a-3p, mir-10a-5p, and miR5p to be most strongly associated with LVI. +other 34316330 hsa-mir-10a Head and Neck Neoplasms We further refined these findings using a Random forest approach, and miR-203a-3p, mir-10a-5p, and miR5p to be most strongly associated with LVI. +other 34315950 hsa-mir-4454 Parkinson Disease 3p and miR-4454 has the potential to serve as a non-invasive biomarker for PD diagnosis. +other 34315584 hsa-mir-171f Parastremmatic dwarfism Meanwhile, the microRNA data showed that the miR171f_3 demonstrated the active involvement in GA pathway response in persimmon dwarfism. +circulation_biomarker_diagnosis_ns 34315539 hsa-mir-22 Parkinson Disease CONCLUSIONS: The 6 serum EV-derived miRNAs, hsa-miR-374a-5p, hsa-miR-374b-5p, hsa-miR-199a-3p, hsa-miR +circulation_biomarker_diagnosis_ns 34315539 hsa-mir-374b Parkinson Disease CONCLUSIONS: The 6 serum EV-derived miRNAs, hsa-miR-374a-5p, hsa-miR-374b-5p, hsa-miR-199a-3p, hsa-miR +circulation_biomarker_diagnosis_ns 34315539 hsa-mir-199a Parkinson Disease CONCLUSIONS: The 6 serum EV-derived miRNAs, hsa-miR-374a-5p, hsa-miR-374b-5p, hsa-miR-199a-3p, hsa-miR +circulation_biomarker_diagnosis_ns 34315539 hsa-mir-28 Parkinson Disease CONCLUSIONS: The 6 serum EV-derived miRNAs, hsa-miR-374a-5p, hsa-miR-374b-5p, hsa-miR-199a-3p, hsa-miR +circulation_biomarker_diagnosis_ns 34315539 hsa-mir-151a Parkinson Disease CONCLUSIONS: The 6 serum EV-derived miRNAs, hsa-miR-374a-5p, hsa-miR-374b-5p, hsa-miR-199a-3p, hsa-miR +circulation_biomarker_diagnosis_ns 34315539 hsa-mir-374a Parkinson Disease CONCLUSIONS: The 6 serum EV-derived miRNAs, hsa-miR-374a-5p, hsa-miR-374b-5p, hsa-miR-199a-3p, hsa-miR +other 34315491 hsa-mir-99a Colorectal Neoplasms A novel miRNA-mRNA network capable of predicting the prognosis and confirmed experimentally, hsa-miR-99a-HS3ST2-hsa-miR-100, was found after expression analysis in metastasized lymph node tissue from CRC samples. +other 34315491 hsa-mir-100 Colorectal Neoplasms A novel miRNA-mRNA network capable of predicting the prognosis and confirmed experimentally, hsa-miR-99a-HS3ST2-hsa-miR-100, was found after expression analysis in metastasized lymph node tissue from CRC samples. +genetics_overexpression_promote 34314996 hsa-mir-199a Carcinoma, Hepatocellular It was also found that miR-199a-5p overexpression declined the development of the cells with HCC and that it could bind to CDC25A to suppress the progression of HCC. +genetics_overexpression_promote 34314948 hsa-mir-4323 Colorectal Neoplasms miR-4323 overexpression decreased cell proliferation rate via induction of cell apoptosis in colorectal cancer cells. +genetics_overexpression_promote 34314629 hsa-mir-21 Endometrial Neoplasms A cells, overexpression of circFAT1 increased the expression levels of miR-21 and decreased the methylation of miR-21 gene, whereas overexpression of miR-21 did not alter the expression of circFAT1. +genetics_knock down_promote 34314382 hsa-mir-1252 Pancreatic Carcinoma 5p overexpression inhibits the proliferation, migration, invasion, and epithelial-mesenchymal transition of PAC cells, and miR +genetics_overexpression_promote 34314379 hsa-mir-198 Carcinoma, Hepatocellular CircSP3 overexpression in HCC cells induced expression of cyclin-dependent kinase 4, a target gene of miR-198. +genetics_overexpression_promote 34313969 hsa-mir-1299 Stomach Neoplasms Additionally, the proliferation, apoptosis and metastasis of AGS and SGC7901 cells were analyzed after the overexpression of miR-1299. +transcription factor target 34313929 hsa-mir-93 Diabetic Retinopathy CONCLUSION: MiR5p, via targeting Sirt1, could affect the vascular permeability and acellular capillaries and mitigate the inflammation and oxidative stress in the retinas, which may play a critical role in DR. +transcription factor target 34313924 hsa-mir-122 Carcinoma, Hepatocellular 5p which inhibits the hallmark glycolytic enzymes and ultimately the metabolic activity of HCC cells. +lncRNA target 34313922 hsa-mir-200b Esophageal Neoplasms To explore function of LINC00667/miR-200b-3p/SLC2A3 axis may provide an informative biomarker of malignancy and a highly selective anti-EC therapeutic target. +circRNA target 34313883 hsa-mir-543 Stomach Neoplasms Our findings demonstrated that enforced expression of circ_0001017 suppressed malignant behaviors and enhanced CDDP sensitivity of CDDP-resistant GC cells at least partially by the miR-543/PHLPP2 axis. +genetics_knock down_suppress 34313802 hsa-mir-1 Cataract, posterior polar, 3 Following adeno-associated virus (AAV)-mediated knockdown or overexpression of miR +other 34313719 hsa-mir-26a Colorectal Neoplasms Furthermore, clinical analysis results show that Smad1 is positively correlated with MALAT1 and negatively correlated with miR-26a-5p in CRC samples. +other 34313533 hsa-mir-218 Atherosclerosis 5p/IGF2 axis. +lncRNA target 34313407 hsa-let-7i Acute Coronary Syndrome CONCLUSIONS: The present study identified that miR-let-7i significantly reduces Fas and FasL expression in ACS CD4+ T cells and inhibits apoptosis in these cells. Therefore, miR-let-7i may serve as a possible therapeutic target for the treatment of ACS. +lncRNA target 34313353 hsa-mir-296 Carcinoma, Non-Small-Cell Lung CircWHSC1 silence significantly inhibited colony formation, viability, invasion, and migration, while increased NSCLC cell apoptosis, which were partially rescued by anti-miR +genetics_knock down_promote 34313249 hsa-mir-212 Prostatic Neoplasms Depletion of exosomal circHIPK3 or overexpression of exosomal miR-212 reduced viability, migration and invasion, but promoted cell apoptosis in PCa cells, which was attenuated by miR-212 inhibition or BMI-1, respectively. Exosomal circHIPK3 knockdown inhibited PCa progression by regulating miR-212/BMI-1 axis, at least in part, offering a new insight into the molecular mechanism of PCa. +genetics_GWAS 34313201 hsa-mir-146a Gout CONCLUSION: Our results indicate that there is no evidence for the involvement of the miR-146a rs2910164 polymorphisms in susceptibility to primary gout in the Chinese Han population. +circulation_biomarker_diagnosis_ns 34312906 hsa-mir-122 Fatty Liver TAM-induced steatohepatitis was evidenced by elevated liver triglycerides and cholesterol contents, increased serum miRNA-122 level, and ALT activity, in parallel with accumulation of lipid droplets, focal necrosis, and inflammatory cells infiltration in hepatocytes. +circulation_biomarker_diagnosis_ns 34312814 hsa-mir-200a Renal Insufficiency, Chronic 3p, and hsa-miR-200a-5p serum expression level in CKD population and reduction of hsa-miR-29a-5p, hsa-miR +circulation_biomarker_diagnosis_ns 34312814 hsa-mir-29a Renal Insufficiency, Chronic 3p, and hsa-miR-200a-5p serum expression level in CKD population and reduction of hsa-miR-29a-5p, hsa-miR +circulation_biomarker_diagnosis_ns 34312814 hsa-mir-29a Proteinuria 3p, and hsa-miR-200a-5p serum expression level in CKD population and reduction of hsa-miR-29a-5p, hsa-miR +circulation_biomarker_diagnosis_ns 34312814 hsa-mir-155 Renal Insufficiency, Chronic 3p, and hsa-miR-200a-5p serum expression level in CKD population and reduction of hsa-miR-29a-5p, hsa-miR +circulation_biomarker_diagnosis_ns 34312814 hsa-mir-155 Proteinuria 3p, and hsa-miR-200a-5p serum expression level in CKD population and reduction of hsa-miR-29a-5p, hsa-miR +circulation_biomarker_diagnosis_ns 34312814 hsa-mir-21 Proteinuria 3p, and hsa-miR-200a-5p serum expression level in CKD population and reduction of hsa-miR-29a-5p, hsa-miR +circulation_biomarker_diagnosis_ns 34312814 hsa-mir-21 Renal Insufficiency, Chronic 3p, and hsa-miR-200a-5p serum expression level in CKD population and reduction of hsa-miR-29a-5p, hsa-miR +circulation_biomarker_diagnosis_ns 34312814 hsa-mir-93 Renal Insufficiency, Chronic 3p, and hsa-miR-200a-5p serum expression level in CKD population and reduction of hsa-miR-29a-5p, hsa-miR +other 34312814 hsa-mir-196a Proteinuria 5p, and hsa-miR-196a-5p in CGN with DPE < 3.5 g. +other 34312814 hsa-mir-196a Renal Insufficiency, Chronic 5p, and hsa-miR-196a-5p in CGN with DPE < 3.5 g. +circulation_biomarker_diagnosis_ns 34312814 hsa-mir-214 Proteinuria 3p, and hsa-miR-200a-5p serum expression level in CKD population and reduction of hsa-miR-29a-5p, hsa-miR +circulation_biomarker_diagnosis_ns 34312814 hsa-mir-200a Proteinuria 3p, and hsa-miR-200a-5p serum expression level in CKD population and reduction of hsa-miR-29a-5p, hsa-miR +circulation_biomarker_diagnosis_ns 34312814 hsa-mir-214 Renal Insufficiency, Chronic 3p, and hsa-miR-200a-5p serum expression level in CKD population and reduction of hsa-miR-29a-5p, hsa-miR +circulation_biomarker_diagnosis_ns 34312814 hsa-mir-93 Proteinuria 3p, and hsa-miR-200a-5p serum expression level in CKD population and reduction of hsa-miR-29a-5p, hsa-miR +exosome 34312802 hsa-mir-193b Mastitis In summary, these findings provide strong evidence that exosomal miR-193b-5p could be a regulator of LPS-induced inflammation in Mac-T cells and reveal a new role of exosomal miRNAs in regulating dairy cow mastitis. +genetics_overexpression_suppress 34312797 hsa-mir-181a Thyroid Cancer, Papillary RESULTS: We observed that miR-181a was overexpressed and KLF15 was low expressed in PTC tissues and cell lines. +lncRNA target 34311651 hsa-mir-26a Nerve Degeneration In vitro and in vivo results showed that miR-26a delivered by ASC-EVs inhibited neuronal damage. +other 34311651 hsa-mir-26a Reperfusion Injury ASC-EVs protected neuronal cells against neuronal damage following cerebral ischemia/reperfusion, which was related to transfer of miR-26a into neuronal cells. +transcription factor target 34311527 hsa-mir-21 Sepsis In animal model of sepsis, the protective influence of Hyp against sepsis-induced cardiac dysfunction was attenuated by miR-21 upregulation. CONCLUSION: Our findings demonstrated that Hyp may serve as a promising natural drug for the treatment of sepsis-associated cardiac dysfunction, and its protective role may exerted through regulating cardiomyocyte viability and inflammation by suppressing miR-21. +lncRNA target 34311444 hsa-mir-541 Osteoporosis-pseudoglioma syndrome Overall, MT modulates the osteogenic and adipogenic differentiation of BMSCs by mediating H19/miR3p/APN axis, providing a new reference for the targeted therapy of OP. +other 34311444 hsa-mir-541 Osteoporosis The results showed that MT, H19 and APN were down-regulated, while miR3p was up-regulated in the OVX rat model. +other 34311393 hsa-mir-146b Esophageal Neoplasms RESULTS: The PBMC expression of miR-146b and TNFA was downregulated in ESCC patients as compared to healthy subjects. +lncRNA target 34311261 hsa-mir-1236 Severe Acute Respiratory Syndrome As a part of our genomics study on host-virus-plant interaction, we identified one unique 3'UTR conserved site 'GGAAGAG' amongst 5024 globally submitted SARS-CoV-2 complete genomes, which can be targeted by the human miRNA 'hsa-miR3p' and by Z. +other 34311261 hsa-mir-477 Severe Acute Respiratory Syndrome Additionally, we also predicted that the members of miR477 family commonly found in these three plant genomes possess an inherent potential to silence viral genome RNA and facilitate antiviral defense against SARS-CoV-2 infection. +transcription factor target 34311140 hsa-mir-1 Chemical and Drug Induced Liver Injury CONCLUSIONS: miR-31 can down-regulate Cdc42 to restrict overactivation of reactive oxygen species/JNK/mitochondria necrotic death loop in hepatocytes of APAP-induced DILI, which might provide a new therapeutic target for alleviating JNK overactivation-based liver injury. +genetics_overexpression_suppress 34311013 hsa-mir-497 Myocardial Reperfusion Injury miR-497 mimics or si-IGF1 blocked the effects of HCP5 overexpression. +other 34310913 hsa-mir-133a Repolarization Abnormality Mir-133a-3p induced repolarization abnormalities in the atrial working myocardium and the L-type calcium current (I(Ca,L)) was significantly increased. +lncRNA target 34310900 hsa-mir-194 Cicatrix, Hypertrophic In conclusion, the findings suggested that H19 may inhibit the apoptosis and promote the proliferation of HSFs through the miR-194/IGF1R/p38 MAPK signaling axis, thereby contributing to the progression of hypertrophic scars. +other 34310833 hsa-mir-214 Acute Heart Failure CONCLUSION: MiR-214, BNP, NT-proBNP and sST2 can be used as effective biomarkers for AHF, providing a new strategy for diagnosis and for judging the severity of AHF. +circulation_biomarker_diagnosis_ns 34310809 hsa-mir-375 Arthritis, Rheumatoid CONCLUSION: Early detection of RA could be achieved through evaluation of serum expression of miR-224, miR-760, miR5p, miR-378 and miR-375 which also may be used as targets for treatment of patients with RA. +circulation_biomarker_diagnosis_ns 34310809 hsa-mir-224 Arthritis, Rheumatoid CONCLUSION: Early detection of RA could be achieved through evaluation of serum expression of miR-224, miR-760, miR5p, miR-378 and miR-375 which also may be used as targets for treatment of patients with RA. +circulation_biomarker_diagnosis_ns 34310809 hsa-mir-378 Arthritis, Rheumatoid CONCLUSION: Early detection of RA could be achieved through evaluation of serum expression of miR-224, miR-760, miR5p, miR-378 and miR-375 which also may be used as targets for treatment of patients with RA. +circulation_biomarker_diagnosis_ns 34310809 hsa-mir-483 Arthritis, Rheumatoid CONCLUSION: Early detection of RA could be achieved through evaluation of serum expression of miR-224, miR-760, miR5p, miR-378 and miR-375 which also may be used as targets for treatment of patients with RA. +genetics_knock down_promote 34309414 hsa-mir-205 Uterine Cervical Neoplasms In conclusion, the overexpression of lncRNA HNRNPU-AS1 suppressed CC progression by inhibiting the Wnt/beta-catenin pathway through the miR +lncRNA target 34308851 hsa-let-7c Urinary Bladder Neoplasms CONCLUSION: miR-let-7c-5p inhibits EMT of bladder cancer UM-UC-3 cells by targeting HMGA2, thereby inhibiting the cell invasion and migration. +genetics_knock down_promote 34308850 hsa-mir-424 Carcinoma, Hepatocellular 5p or overexpressing ATG14 significantly promoted cell proliferation and inhibited cell apoptosis (P < 0.05). +lncRNA target 34308776 hsa-mir-9 Reperfusion Injury, Hepatic Ischemia 3p in hepatic ischemia/reperfusion injury (HIRI) via targeting fibronectin type III domain containing 3B (FNDC3B) remains seldom investigated. +lncRNA target 34308771 hsa-mir-16 Colorectal Neoplasms Moreover, our results suggest AGAP2-AS1 promoted CRC progression by sponging the hsa-miR-15/16 family and upregulation of their targets. +lncRNA target 34308771 hsa-mir-15 Colorectal Neoplasms Moreover, our results suggest AGAP2-AS1 promoted CRC progression by sponging the hsa-miR-15/16 family and upregulation of their targets. +circRNA target 34308761 hsa-mir-195 Uterine Cervical Neoplasms We conclude that circ_0000228 is an oncogenic circRNA, which participates in promoting CC progression via regulating the miR +genetics_overexpression_suppress 34308752 hsa-mir-148a Leukemia, Myeloid, Acute CDK6 overexpression reversed the effects of miR-148a-3p on AML cells. +transcription factor target 34308746 hsa-mir-381 Sarcoma, Ewing 3p expression to inhibit apoptosis induced by ERS in HUVECs and this process was found to be mediated by caspase-4. +other 34308576 hsa-mir-221 Breast Neoplasms MiR-221 Expression Level Correlates with Insulin-Induced Doxorubicin Resistance in MCF-7 Breast Cancer Cells. +genetics_GWAS 34308574 hsa-mir-196a-2 Colorectal Neoplasms In the current study, we aimed to investigate association between rs11614913 polymorphism of the miRa2 gene and CRC. +other 34308569 hsa-mir-205 Melanoma CONCLUSION: We suggested here that miR-205, -15b, -203, -9 pattern as the key miRNAs linked to melanoma status, the pluripotency, proliferation, and motility of malignant cells. +genetics_GWAS 34308291 hsa-mir-137 Schizophrenia Compared with the PRS derived from the whole genome or the target genes of TCF4, the PRS of neuronal MIR137 -target genes explained a disproportionally larger (relative to SNP number) SZ risk in the European sample, but with a more modest advantage in the Han Chinese sample. +transcription factor target 34307695 hsa-mir-29 Carcinoma, Hepatocellular Moreover, a new miRNA, miR3p, targeting KDM1A was found to regulate the PD-L1 expression profile in HCC cells. +genetics_overexpression_suppress 34307682 hsa-mir-101 Carcinoma, Renal Cell RESULTS: The overexpression of miR +other 34307674 hsa-mir-451 Myocardial Ischemia Reducing the expression of mir-451 can enhance the activity of AMPK signal pathway, and the increase of AMPK signal pathway activity is beneficial to reduce myocardial ischemia-reperfusion injury. +other 34307674 hsa-mir-451 Reperfusion Injury Reducing the expression of mir-451 can enhance the activity of AMPK signal pathway, and the increase of AMPK signal pathway activity is beneficial to reduce myocardial ischemia-reperfusion injury. +lncRNA target 34307670 hsa-mir-103a Carcinoma, Non-Small-Cell Lung CONCLUSION: miR-103a-3p promotes the progression of NSCLC via Akt signaling by targeting PTEN, highlighting the role of miR-103a-3p/PTEN/Akt signaling and suggesting miR-103a-3p as a novel therapeutic target for NSCLC. +lncRNA target 34307661 hsa-mir-4741 Intervertebral Disc Degeneration The increased expression of NEAT1 might inhibit miR-5100 and subsequently upregulate the expression of COL10A1, which leads to IDD, while the increased expression of miR663AHG/HEIH/hsa-circ-0003600 might inhibit miR-4741 and indirectly upregulate HAS2/HYAL1/LYVE1, and leads to the protection from IDD. +lncRNA target 34307661 hsa-mir-663a Intervertebral Disc Degeneration The increased expression of NEAT1 might inhibit miR-5100 and subsequently upregulate the expression of COL10A1, which leads to IDD, while the increased expression of miR663AHG/HEIH/hsa-circ-0003600 might inhibit miR-4741 and indirectly upregulate HAS2/HYAL1/LYVE1, and leads to the protection from IDD. +lncRNA target 34307661 hsa-mir-5100 Intervertebral Disc Degeneration The increased expression of NEAT1 might inhibit miR-5100 and subsequently upregulate the expression of COL10A1, which leads to IDD, while the increased expression of miR663AHG/HEIH/hsa-circ-0003600 might inhibit miR-4741 and indirectly upregulate HAS2/HYAL1/LYVE1, and leads to the protection from IDD. +exosome 34307654 hsa-mir-145 Breast Neoplasms METHODS: Here, we exploited the exosomes from adipose tissue-derived mesenchymal stem cells (MSC-Exo) to deliver miR-145 in the T-47D breast cancer cell line. +transcription factor target 34307490 hsa-mir-140 Atherosclerosis They have potential regulatory effects on atherosclerosis and vascular endothelial injury by targeting miR-30d-3p-TP53RK and miR3p-MKK6 axis and their downstream signaling pathways. +genetics_knock down_promote 34307457 hsa-mir-615 Prostatic Neoplasms In addition, we observed that knockdown of miR +lncRNA target 34307388 hsa-mir-181d Adenocarcinoma of Lung As expected, the inhibitory effects of miR-181d-5p on LUAD cell proliferation, migration, and invasion were counteracted by restoration of C1GALT1. +lncRNA target 34307360 hsa-mir-519e Stomach Neoplasms All investigations indicated that Lnc_ASNR functioned as a ceRNA targeting miR-519e-5p and facilitated GC development by regulating the pathway of miR-519e-5p/FGFR2. +exosome 34307356 hsa-mir-377 Esophageal Neoplasms Exosomes Mediated Transfer of Circ_0000337 Contributes to Cisplatin (CDDP) Resistance of Esophageal Cancer by Regulating JAK2 via miR-377-3p. +epigenetics 34307152 hsa-mir-34a Osteosarcoma Long Noncoding RNA DICER1-AS1 Functions in Methylation Regulation on the Multi-Drugresistance of Osteosarcoma Cells via miR-34a-5p and GADD45A. +circRNA target 34307012 hsa-mir-152 Multiple Myeloma CONCLUSION: These results suggested that circRERE could suppress the BTZ resistance in MM cells by mediating the miR +lncRNA target 34306585 hsa-mir-890 Adenocarcinoma of Lung Notably, SNHG3 was found to promote LUAD progression by targeting miR-890. In conclusion, the findings of the present study revealed that lncRNA SNHG3 promoted the occurrence and progression of LUAD by regulating miR-890 expression. +other 34306495 hsa-mir-210 Hypertensive Disorder Complicating Pregnancy CONCLUSION: miR-19a, miR-126, and miR-210 are strongly connected to the severity of HDCP and can be used as a sensitive indicator to predict HDCP patients clinically. +other 34306495 hsa-mir-19a Hypertensive Disorder Complicating Pregnancy CONCLUSION: miR-19a, miR-126, and miR-210 are strongly connected to the severity of HDCP and can be used as a sensitive indicator to predict HDCP patients clinically. +other 34306495 hsa-mir-126 Hypertensive Disorder Complicating Pregnancy RESULTS: The miR-19a and miRNA-210 expressions were higher in the HDCP group, the mild preeclampsia group, and the severe preeclampsia group than they were in the normal group, and the miR-126 expression was lower (all P<0.05). The miR-19a and miRNA-210 expression levels in the severe preeclampsia group were higher than they were in the HDCP group, and the miR-126 expression was lower (P<0.05). +circulation_biomarker_prognosis_ns 34306419 hsa-mir-197 Carcinoma, Hepatocellular RESULTS: The miR-122 and miR-197 levels in the LC tissues were lower than they were in the adjacent tissues, and they increased in the peripheral blood after chemotherapy. +circulation_biomarker_prognosis_ns 34306419 hsa-mir-122 Carcinoma, Hepatocellular RESULTS: The miR-122 and miR-197 levels in the LC tissues were lower than they were in the adjacent tissues, and they increased in the peripheral blood after chemotherapy. +other 34306411 hsa-mir-146a Periodontitis CONCLUSION: MiR-155 and miR-146a were both highly expressed in the saliva of patients with PD, and the expression of them was positively correlated with the severity and clinical indexes of PD, so miR-155 and miR-146a might be involved in the development and progression of PD. +other 34306411 hsa-mir-46a Periodontitis CONCLUSION: MiR-155 and miR-146a were both highly expressed in the saliva of patients with PD, and the expression of them was positively correlated with the severity and clinical indexes of PD, so miR-155 and miR-146a might be involved in the development and progression of PD. +other 34306411 hsa-mir-155 Periodontitis CONCLUSION: MiR-155 and miR-146a were both highly expressed in the saliva of patients with PD, and the expression of them was positively correlated with the severity and clinical indexes of PD, so miR-155 and miR-146a might be involved in the development and progression of PD. +circulation_biomarker_prognosis_ns 34306405 hsa-mir-20a Stomach Neoplasms RESULTS: miR-338 expression was low in GC patients' serum, while miR-20a was high in GC patients. +circulation_biomarker_prognosis_ns 34306405 hsa-mir-338 Stomach Neoplasms RESULTS: miR-338 expression was low in GC patients' serum, while miR-20a was high in GC patients. +lncRNA target 34306364 hsa-mir-1285 Squamous Cell Carcinoma of Head and Neck 3p to regulate the expression of TFAP2A, promote invasion and inhibit apoptosis of HNSCC cells. +other 34306359 hsa-mir-145 Cicatrix, Hypertrophic 5p to induce the expression of TGF-beta2, and then promote the proliferation of HS fibroblasts and secretion of VEGF, which is expected to be effective in the treatment of HS. +lncRNA target 34306346 hsa-mir-889 Carcinoma, Hepatocellular In conclusion, these findings demonstrate that circUBE2D2 accelerated the HCC glycolysis and sorafenib resistance via circUBE2D2/miR3p/LDHA axis, which provides a novel approach for HCC treatment. +target gene 34306345 hsa-mir-195 Colorectal Neoplasms LncRNA LINC00473 promoted colorectal cancer cell proliferation and invasion by targeting miR-195 expression. +other 34306343 hsa-mir-577 Uterine Cervical Neoplasms circMYC promotes cell proliferation, metastasis, and glycolysis in cervical cancer by up-regulating MET and sponging miR-577. +lncRNA target 34306338 hsa-mir-133b Triple Negative Breast Neoplasms CONCLUSION: To sum up, miR-133b can inhibit the growth and DDP resistance of TNBC cells by targeting FGFR1 and inactivating the Wnt-beta-catenin pathway. +transcription factor target 34306337 hsa-mir-192 Diabetic Nephropathies 5p expression, thus offering a new strategies and target for Urethral stricture. +circRNA target 34306334 hsa-mir-1278 Thyroid Cancer, Papillary Our findings revealed that circNEURL4 may probably serve as a diagnostic marker to predict PTC patients' prognosis and a possible therapeutic target to PTC via miR-1278/LATS1 axis. +other 34306333 hsa-mir-3972 Stomach Neoplasms RP11-874J12.4, a novel lncRNA, confers chemoresistance in human gastric cancer cells by sponging miR-3972 and upregulating SSR2 expression. +circulation_biomarker_diagnosis_up 34306331 hsa-mir-128 Retinoblastoma RESULTS: ZNRD1-AS1 was up-regulated in the cytoplasm of retinoblastoma and regulated BMI1 via sponging miR +target gene 34306329 hsa-mir-625 Carcinoma, Non-Small-Cell Lung silencing of H19 could inhibit APEX1 expression by upregulating miR-625-5p, thereby accelerating DNA damage repair in A549 cells. +lncRNA target 34306328 hsa-mir-195 Colorectal Neoplasms These findings indicate that NEAT1 and XIST are potential prognostic factors that affect CRC onset and progression by targeting miR +circulation_biomarker_diagnosis_up 34306253 hsa-mir-181b Heart Failure Besides, miR-181b expressions were negatively correlated with hypersensitive C-reactive protein (hsCRP) levels in the serum of HF patients. +target gene 34306207 hsa-mir-374a Carcinoma, Non-Small-Cell Lung miR-374a-5p inhibits non-small cell lung cancer cell proliferation and migration via targeting NCK1. +lncRNA target 34306199 hsa-mir-124 Glioma Based on these results, the present study concluded that miR-124 is critical for amelioration of glioma by targeting EMMPRIN, thereby acting as a tumor suppressor. +other 34306197 hsa-mir-433 Brain Injuries, Traumatic The present study examined the expression of osteopontin (SPP1) in the tibial fracture callus and heterotopic ossification tissues in craniocerebral injury and investigated its relationship with miR-433. SPP1 mRNA and protein expression was elevated in patients who had tibial fracture in combination with craniocerebral injury in comparison with controls By contrast, expression of miR-433 was decreased in patients who had tibial fracture in combination with craniocerebral injury in comparison with controls. +genetics_knock down_promote 34306188 hsa-mir-3926 Arthritis, Rheumatoid In conclusion, ZFAS1 knockdown inhibited RA-FLS proliferation, migration, invasion and inflammatory cytokine production, and induced apoptosis in RA via the miR-3926/FSTL1 axis. +transcription factor target 34306155 hsa-mir-132 Neointimal Hyperplasia In addition, our findings revealed that CCE3 significantly increased the expression of miRNA-132, an inhibitory regulator of inflammation and restenosis, and suppressed the expression of inflammation-related molecules (inducible nitric oxide synthase, cyclooxygenase-2, interleukin- (IL-) 1beta, and IL-6). +other 34306080 hsa-mir-29b Urinary Bladder Neoplasms Subsequently, the expression of YB-1 and miR-29b-3p was regulated in the BC cell lines where we noted that YB-1 promoted VEGFA expression by downregulating the expression of miR- 29b-3p. +transcription factor target 34306074 hsa-mir-30 Thyroid Neoplasms 5p facilitated the TC progression through targeting FOXE1, which may offer novel therapeutic options for TC. +circulation_biomarker_diagnosis_ns 34306018 hsa-mir-631 Carcinoma, Non-Small-Cell Lung 3p, and miR-631 might be a promising serum biomarker in patients for the early diagnosis of NSCLC. +circulation_biomarker_diagnosis_ns 34306018 hsa-mir-590 Carcinoma, Non-Small-Cell Lung 3p, and miR-631 might be a promising serum biomarker in patients for the early diagnosis of NSCLC. +circulation_biomarker_diagnosis_ns 34306018 hsa-mir-492 Carcinoma, Non-Small-Cell Lung 3p, and miR-631 might be a promising serum biomarker in patients for the early diagnosis of NSCLC. +circulation_biomarker_diagnosis_down 34305636 hsa-mir-455 Myocardial Infarction Conclusion: Circulating miR-1291, miR-217, miR +circulation_biomarker_diagnosis_down 34305636 hsa-mir-217 Myocardial Infarction Conclusion: Circulating miR-1291, miR-217, miR +circulation_biomarker_diagnosis_down 34305636 hsa-mir-1291 Myocardial Infarction Conclusion: Circulating miR-1291, miR-217, miR +target gene 34305410 hsa-mir-1224 Triple Negative Breast Neoplasms The low TUSC7 expression is an independent prognostic factor of poor OS of TNBC patients. TUSC7 might inhibit breast cancer cell growth and metastasis both in vitro and vivo through binding with miR-1224-3P and regulating MAPK, PI3K/AKT, and NF-κB signaling pathways. +genetics_overexpression_promote 34305409 hsa-mir-497 Carcinoma, Hepatocellular Analysis of cellular behaviors showed that overexpression of circRNA SCARB1 increased the proliferation and migration of HCC cells, while overexpression of miR-497 decreased cell proliferation and migration. +other 34305242 hsa-mir-101 Adenocarcinoma of Lung miRNA-101 replacement therapy can be considered as an effective therapeutic strategy in non-small cell lung cancer. +transcription factor target 34305233 hsa-mir-155 COVID-19 Also, the relative expression of pro-neuroinflammatory miRNAs (mir-326, mir-155, and mir-27b) was increased and the relative expression of their target mRNA (PPARS, SOCS1, and CEBPA) was decreased in COVID-19 patients with increase of disease grade. A negative significant correlation was seen between mir-21 and IL-12p53 mRNA, mir-124 and Stat3 mRNA, mir-146a and TRAF6 mRNA, mir-27b and PPARS mRNA, mir-155 and SOCS1 mRNA, and between mir-326 and CEBPA mRNA in COVID-19 patients (P < 0.05). +transcription factor target 34305233 hsa-mir-27b COVID-19 Also, the relative expression of pro-neuroinflammatory miRNAs (mir-326, mir-155, and mir-27b) was increased and the relative expression of their target mRNA (PPARS, SOCS1, and CEBPA) was decreased in COVID-19 patients with increase of disease grade. A negative significant correlation was seen between mir-21 and IL-12p53 mRNA, mir-124 and Stat3 mRNA, mir-146a and TRAF6 mRNA, mir-27b and PPARS mRNA, mir-155 and SOCS1 mRNA, and between mir-326 and CEBPA mRNA in COVID-19 patients (P < 0.05). +transcription factor target 34305233 hsa-mir-326 COVID-19 Also, the relative expression of pro-neuroinflammatory miRNAs (mir-326, mir-155, and mir-27b) was increased and the relative expression of their target mRNA (PPARS, SOCS1, and CEBPA) was decreased in COVID-19 patients with increase of disease grade. A negative significant correlation was seen between mir-21 and IL-12p53 mRNA, mir-124 and Stat3 mRNA, mir-146a and TRAF6 mRNA, mir-27b and PPARS mRNA, mir-155 and SOCS1 mRNA, and between mir-326 and CEBPA mRNA in COVID-19 patients (P < 0.05). +genetics_overexpression_promote 34305100 hsa-mir-940 Osteosarcoma Furthermore, the transfection of miR-940 mimics or SFRP1 small interfering RNA could reverse the impact of circ_0046264 overexpression on the growth, migration and invasion of osteosarcoma cells. Taken together, circ_0046264 is a tumor suppressor to inhibit the osteosarcoma progression via modulating the miR-940 / SFRP1 axis. +transcription factor target 34303763 hsa-mir-4310 Carcinoma, Hepatocellular By suppressing SCD1-and FASN-mediated lipid synthesis, miR-4310 inhibits HCC cell proliferation, migration, and invasion in vitro and suppresses HCC tumor growth and metastasis in vivo. +transcription factor target 34303273 hsa-mir-133a Atrial Fibrillation CONCLUSION: H(2)S improved myocardial cell fibrosis by significantly increasing the expression of miR-133a, and CTGF might be a potential target for miR-133a to play an important role in myocardial fibrosis. +transcription factor target 34303273 hsa-mir-133a Fibrosis, Atrial CONCLUSION: H(2)S improved myocardial cell fibrosis by significantly increasing the expression of miR-133a, and CTGF might be a potential target for miR-133a to play an important role in myocardial fibrosis. +lncRNA target 34302879 hsa-mir-142 Neurodegenerative Diseases 5p) has been found to be dysregulated in several neurodegenerative disorders. +genetics_overexpression_promote 34302635 hsa-mir-217 Ovarian Neoplasms Furthermore, miR-217 mimic reversed the inhibitory effect of SNHG20 overexpression on the biological behavior of ovarian cancer cells. +genetics_overexpression_suppress 34302585 hsa-let-7g Carcinoma, Renal Cell Expression of microRNA-301a, microRNA-23b in the clear cell renal cell carcinoma tissues was significantly overexpressed when compared with the adjacent normal tissues and let-7 g was significantly downregulated in tumor. +lncRNA target 34301920 hsa-mir-4293 Lung Neoplasms These results provided a valuable theoretical basis for the discovery of lung carcinoma therapeutic targets and diagnostic markers based on miR-4293 and WFDC21P. +other 34301845 hsa-mir-21 Sepsis Together, these findings demonstrate that expression of miR-21 in myeloid cells orchestrates the balance between anti-inflammatory mediators and metabolic reprogramming that drives cytokine storm during sepsis. +other 34301843 hsa-mir-10a Colitis Blocking the IL-10/IL-10R pathway in vivo aggravated colitis induced by miR-10a-deficient CD4(+)CD45Rb(hi) T cells. +tissue_expression_ns 34301766 hsa-mir-200 Lung Neoplasms miR-200 deficiency in lung cancer cells promotes the proliferation and activation of adjacent cancer-associated fibroblasts (CAFs), which in turn elevates the metastatic potential of cancer cells. +genetics_GWAS 34301176 hsa-let-7i Diabetes Mellitus, Type 2 MRNA-miRNA co-expression network and mRNA-SNP-miRNA interaction network illustrated that let-7i-5p, RASGRP3, KRT1 and CEP41 may be potential biomarkers for the early detection and diagnosis of CVD in T2DM patients. CONCLUSION: Our results suggested that downregulated let-7i-5p, and upregulated RASGRP3, KRT1 and CEP41 may play crucial roles in molecular mechanisms underlying the initiation and development of CVD in T2DM patients. +other 34301174 hsa-mir-135 Pre-Eclampsia CONCLUSIONS: Altogether, we demonstrate that up-regulated miR-135 or reduced PCSK6 attenuates inflammatory response in PE by restricting NLRP3 inflammasome, which provides novel therapy for PE treatment. +other 34300256 hsa-mir-21 Emergence Delirium 5p, GFAP and NSP for monitoring postoperative recovery warrants further research considering their potential to predict PD and ePOCD. +transcription factor target 34299605 hsa-mir-145 Breast Neoplasms Our data indicate a potential chemoprevention role of PEBP through the modulation of miRNA expression, particularly miR-210 and miR-145, and protection against breast cancer development and progression. +transcription factor target 34299605 hsa-mir-210 Breast Neoplasms Our data indicate a potential chemoprevention role of PEBP through the modulation of miRNA expression, particularly miR-210 and miR-145, and protection against breast cancer development and progression. +lncRNA target 34299277 hsa-mir-142 Carcinoma, Non-Small-Cell Lung 3p target genes (NUP205, RAN, CSE1L, SNRPD1, RPS11, SF3B1, COPA, ARCN1, and SNRNP200) had a significant impact on proliferation in 100% of the tested NSCLC cell lines in CRISPR-Cas9 (n = 78) and RNA interference (RNAi) screening (n = 92). +genetics_GWAS 34299137 hsa-mir-193a Colorectal Neoplasms In silico analysis of the publicly available GEO (GSE66548) dataset of KRAS-mutated versus KRAS wild-type CRC patients confirmed that miR-193a-3p was significantly downregulated in the former compared with the latter patient population. Overexpression of miR-193a-3p considerably reduced the oncogenicity of both CRC cells. +other 34299119 hsa-mir-203a Dyslipidemias Interestingly, decreases in miR-203a-3p and miR-29a/b/c, both implicated in dyslipidemia, were also observed in these Delta9-THC-exposed offspring. +other 34299119 hsa-mir-29a Dyslipidemias Interestingly, decreases in miR-203a-3p and miR-29a/b/c, both implicated in dyslipidemia, were also observed in these Delta9-THC-exposed offspring. +other 34298410 hsa-mir-375 Uterine Cervical Neoplasms MiR-143, miR-372, miR-375 and miR-30c were markedly downregulated in HSIL and cervical SCC. +other 34298410 hsa-mir-372 Uterine Cervical Neoplasms MiR-143, miR-372, miR-375 and miR-30c were markedly downregulated in HSIL and cervical SCC. MiR-30a, miR-520e, miR-548c and miR-372 were significantly associated with the overall survival of cervical SCC patients and these miRNAs were determined to be significant diagnostic markers as revealed by ROC analysis. +other 34298410 hsa-mir-143 Uterine Cervical Neoplasms MiR-143, miR-372, miR-375 and miR-30c were markedly downregulated in HSIL and cervical SCC. +genetics_overexpression_promote 34298254 hsa-mir-211 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Further, TCF12 was the direct target of miR-211, miR-211 bound to TCF12 mRNA 3;-untranslated region (UTR) and increased its decay, overexpression of TCF12 could effectively rescue the weakened malignant behavior of T-LBL cells caused by miR-211 overexpression. +genetics_overexpression_promote 34298200 hsa-mir-126 Diabetes Mellitus "Finally, miR-126 overexpression confered ""diabetic"" phenotype to non-T2DM VSMCs by downregulating PI3K/AKT axis. CONCLUSIONS: miR-126 plays crucial roles in T2DM VSMC metabolic memory through activation of MEK/ERK pathway, enhancing the efficacy of Kv1.3 blockers in the prevention of restenosis in T2DM patients." +other 34298004 hsa-mir-495 Breast Neoplasms Together, these data suggest interplay between miR3p, TGF-beta2 and FOXC1 regulating MDR in MBC and open the exploration of novel therapeutic strategies. +circulation_biomarker_prognosis_ns 34297787 hsa-mir-29a Breast Neoplasms miRNAs (miR-29a and miR-140, miR-148a) can be an effective diagnostic and prognostic marker as they regulate SMAD4 and SMAD2 expression respectively in breast cancer blood and biopsy samples. +circulation_biomarker_prognosis_ns 34297787 hsa-mir-148a Breast Neoplasms miRNAs (miR-29a and miR-140, miR-148a) can be an effective diagnostic and prognostic marker as they regulate SMAD4 and SMAD2 expression respectively in breast cancer blood and biopsy samples. +circulation_biomarker_prognosis_ns 34297787 hsa-mir-140 Breast Neoplasms miRNAs (miR-29a and miR-140, miR-148a) can be an effective diagnostic and prognostic marker as they regulate SMAD4 and SMAD2 expression respectively in breast cancer blood and biopsy samples. +genetics_overexpression_suppress 34297624 hsa-let-7f Osteoporosis Furthermore, inhibition of let-7f-5p or overexpression of Nme4 in BM-MSCs restored in-vivo bone formation in an ovariectomized animal model. +target gene 34297271 hsa-mir-140 Carcinoma, Hepatocellular inhibitory role of Bie Jia Jian pill+bone mesenchymal stem cells in HCC development through regulating miR-140 and Wnt/β-catenin signal pathway. +lncRNA target 34296954 hsa-mir-493 Adenocarcinoma of Lung 5p targets RASL11B, thereby inhibiting cell growth and inducing apoptosis in LUAD. +circulation_biomarker_diagnosis_ns 34296940 hsa-mir-214 Splenic Neoplasms 5p, miR-543) had significantly different expression in serum between dogs with splenic masses (ie, hemangiosarcoma or hematoma) and serum of dogs with histologically normal spleens, with higher expression in the serum of dogs with splenic masses for all 5 miRNAs. +genetics_GWAS 34296808 hsa-mir-192 Triple Negative Breast Neoplasms Our findings demonstrate that overexpression of epigenetically deregulated miR-192 decreases proliferation, promotes apoptosis, and inhibits migration of TNBC cell lines. +lncRNA target 34296787 hsa-mir-214 Diabetic Neuropathies 3p was delivered via tail vein injection of lentivirus. +transcription factor target 34296780 hsa-mir-26a Osteoarthritis SMSC-EVs carrying miR-26a-5p repaired cartilage damage of OA. CONCLUSIONS: SMSC-EVs carried miR-26a-5p into chondrocytes to up-regulate miR-26a-5p and inhibit PTEN, thereby inhibiting apoptosis and inflammation and ameliorating cartilage damage of OA. +transcription factor target 34296780 hsa-mir-26a Cartilage Diseases SMSC-EVs carrying miR-26a-5p repaired cartilage damage of OA. CONCLUSIONS: SMSC-EVs carried miR-26a-5p into chondrocytes to up-regulate miR-26a-5p and inhibit PTEN, thereby inhibiting apoptosis and inflammation and ameliorating cartilage damage of OA. +lncRNA target 34296550 hsa-mir-139 Leiomyoma 5p is a potential therapeutic target for leiomyoma. +genetics_overexpression_suppress 34296546 hsa-mir-34a Ovarian Neoplasms We found miR-34a overexpression enhanced the inhibitory effects of REV on OC cells, whereas miR-34a inhibition had the opposite effect in OC cells. CONCLUSION: Overall, these results demonstrated that REV exerts anti-cancer effects on OC cells through an miR-34a/Bcl-2 axis, highlighting the therapeutic potential of REV for treatment of OC. +lncRNA target 34296485 hsa-mir-10 Benign Paroxysmal Positional Vertigo mori cold shock domain E1 protein) gene was predicted to be a candidate target gene for BmCPV-miR-10 with the miRNA binding site located in 3' untranslated region of its mRNA. +genetics_overexpression_promote 34296378 hsa-mir-361 Stomach Neoplasms Mechanistically, circTMC5 overexpression promoted GC cell proliferation, invasion, and metastasis but inhibited apoptosis by sponging miR +lncRNA target 34296306 hsa-mir-638 Carcinoma, Non-Small-Cell Lung Bioinformatics and reverse transcriptionquantitative PCR assay confirmed that miR638 was expressed at low levels in NSCLC. In summary, the present study showed that circTADA2A promoted NSCLC cell proliferation and migration via modulating miR638/KIAA0101 signaling. +genetics_knock down_promote 34296305 hsa-mir-128 Spinal Cord Injuries Loss and gainoffunction assays were conducted in rat models of SCI to determine the roles of miR128 and ULK1 in neuronal cell apoptosis, inflammation, and motor function. +lncRNA target 34296298 hsa-mir-34a Enterocolitis, Necrotizing Based on the aforementioned analysis, the miR34a and SIRT1 proteins may be potential novel therapeutic targets in NEC. +other 34296287 hsa-mir-192 Hepatitis B, Chronic The present study aimed to investigate the regulatory role of microRNA192 (miR1925p) and glucagonlike peptide1 (GLP1) in intestinal microbiota imbalance by recruiting patients with DM infected with HBV. +lncRNA target 34296286 hsa-mir-93 Acute Kidney Injury The results of the present study suggested that the protective effect of miR93 on AKI may be associated with the activation of PTEN/AKT/mTOR pathway. miR93 may serve as a potential therapeutic target in sepsisinduced AKI. +genetics_knock down_promote 34296285 hsa-mir-7515 Pancreatic Carcinoma The overexpression of IGF1 reversed the inhibitory effects of miR7515 overexpression on PC cells. +lncRNA target 34295819 hsa-mir-206 Carcinoma, Hepatocellular We also found that FER was directly regulated by miR-206, and the downregulation of miR-206 was associated with proliferation and metastatic progression in HCC. CONCLUSIONS: The present research was the first to reveal that a decrease in miR-206 levels results in an increase in FER expression in HCC, leading to enhanced cell growth and metastatic abilities via activation of the NF-kappaB signaling pathway. +target gene 34295808 hsa-mir-29b Tongue Neoplasms CuB exerts significant anti-cancer activity by regulating expression of XIST via miR-29b. +other 34295807 hsa-mir-153 Breast Neoplasms Circular RNA circ-MMP11 Contributes to Lapatinib Resistance of Breast Cancer Cells by Regulating the miR-153-3p/ANLN Axis. +circulation_biomarker_diagnosis_ns 34295803 hsa-mir-936 Stomach Neoplasms 3p) and three lncRNAs (lnc-MB21D1-3:5, lnc-PSCA-4:2 and lnc-ABCC5-2:1) were abnormally expressed in circulating and tissue samples compared with normal control (NC), which was closely related to clinical pathology and survival time of GC patients; circRNA sequencing and qRT-PCR revealed four circRNAs (circASHL2, circCCDC9, circNHSL1 and cirMLLT10) were abnormally expressed in GC tissues and parts of them were negative relationship with their predicted binding miRNAs. +target gene 34295718 hsa-mir-145 Prostatic Neoplasms Long ncRNA MALAT1 promotes cell proliferation, migration, and invasion in prostate cancer via sponging miR-145. +other 34295698 hsa-mir-497 Diabetes, Gestational The expression of miR5p was prominently reduced in GDM patients and cell models. +lncRNA target 34295552 hsa-mir-133a Stomach Neoplasms However, the effect of miR-133a-5p on gastric cancer (GC) have not been uncovered. CONCLUSIONS: Our findings altogether reveal that miR-133a-5p can serve as a tumor suppressor in gastric cancer via the miR-133a-5p/TCF4 pathway. +lncRNA target 34295552 hsa-mir-133 Stomach Neoplasms However, the effect of miR-133a-5p on gastric cancer (GC) have not been uncovered. CONCLUSIONS: Our findings altogether reveal that miR-133a-5p can serve as a tumor suppressor in gastric cancer via the miR-133a-5p/TCF4 pathway. +circulation_biomarker_diagnosis_ns 34295456 hsa-let-7a Hodgkin Disease Combining EV-miR3p and/or EV-let-7a-5p levels, with serum TARC (a validated protein cHL biomarker), increases the accuracy for predicting PET-status (n = 129) to an area under the curve of 0.93 (CI: 0.87-0.99), 93.5% sensitivity, 83.8/85.0% specificity and a negative predictive value of 96%. +circulation_biomarker_diagnosis_ns 34295456 hsa-mir-127 Hodgkin Disease Combining EV-miR3p and/or EV-let-7a-5p levels, with serum TARC (a validated protein cHL biomarker), increases the accuracy for predicting PET-status (n = 129) to an area under the curve of 0.93 (CI: 0.87-0.99), 93.5% sensitivity, 83.8/85.0% specificity and a negative predictive value of 96%. +lncRNA target 34295384 hsa-mir-340 Colonic Neoplasms 5p could be used to antagonize colon cancer cell metastasis by targeting the FHL2-E-cad axis. +lncRNA target 34295265 hsa-mir-210 spondyloepimetaphyseal dysplasia, Strudwick type Together, these data indicate that the airway epithelium-induced proliferative phenotype of ASMCs is not driven by EGFR signaling, but rather may be dependent on miR210 targeting of tumor suppressor Mnt. +genetics_knock down_suppress 34295155 hsa-mir-197 Pulmonary Disease, Chronic Obstructive CONCLUSION: Circ-RBMS1 knockdown alleviated CSE-induced apoptosis, inflammation and oxidative stress in 16HBE cells via miR3p/FBXO11 axis, suggesting a new insight into the pathogenesis of CS-induced COPD. +transcription factor target 34294459 hsa-mir-155 Pneumonia, Staphylococcal In conclusion, miR-155 regulates Th9 differentiation in children with MRSA by targeting SIRT1. +genetics_overexpression_promote 34294360 hsa-mir-1236 Colorectal Neoplasms 3p inhibitor could reverse the inhibition effect of circ_0101802 silencing on CRC proliferation, migration and invasion, and MACC1 overexpression also could abolish the negative regulation of miR +lncRNA target 34294143 hsa-mir-137 Bone Diseases CONCLUSIONS: Collectively, we proposed a NOTCH1/LSD1/BMP2 co-regulatory signaling network to elucidate the modulation of miR-137 on the osteoblastic differentiation of hASCs, thus providing mechanism-based rationale for miRNA-targeted therapy of bone defect. +exosome 34294138 hsa-mir-378a Colitis CONCLUSION: hucMSC-derived exosomes carrying miR-378a-5p inhibited NLRP3 inflammasomes and abrogated cell pyroptosis to protect against DSS-induced colitis. +other 34294127 hsa-mir-326 Cerebral Hemorrhage CONCLUSIONS: Our study shows that hypoxic preconditioning delays OM-MSC senescence and augments the therapeutic efficacy of OM-MSCs in ICH by upregulating the miR-326/PTBP1/PI3K-mediated autophagy. +lncRNA target 34294084 hsa-mir-411 Glioma CONCLUSION: PSMA3-AS1 stimulated glioma progression via the miR +genetics_overexpression_promote 34294046 hsa-mir-181a Fibrous Dysplasia of Bone miR-181a-5p overexpression reversed the pathophysiologic features of FD BMSCs, whereas miR-181a-5p suppression induced an FD-like phenotype in normal BMSCs. +genetics_overexpression_promote 34294040 hsa-mir-182 Breast Neoplasms 5p overexpression was shown to promote tumor angiogenesis in breast cancer. +lncRNA target 34293926 hsa-mir-146a Carcinoma, Ductal, Breast Through statistical test, a three-miRNA panel (miR5p, miR-34b-3p, miR-146a-5p) was significant for IDC diagnosis (AUC = 0.880, sensitivity = 86.25%, specificity = 81.25%). +lncRNA target 34293926 hsa-mir-34b Carcinoma, Ductal, Breast Through statistical test, a three-miRNA panel (miR5p, miR-34b-3p, miR-146a-5p) was significant for IDC diagnosis (AUC = 0.880, sensitivity = 86.25%, specificity = 81.25%). +lncRNA target 34293926 hsa-mir-9 Carcinoma, Ductal, Breast Through statistical test, a three-miRNA panel (miR5p, miR-34b-3p, miR-146a-5p) was significant for IDC diagnosis (AUC = 0.880, sensitivity = 86.25%, specificity = 81.25%). +lncRNA target 34293716 hsa-mir-149 Prostatic Neoplasms 5p/IL-6 axis may thus be a promising target for therapeutic efforts aimed at PC chemosensitization and treatment. +other 34293701 hsa-mir-1 Cardiomyopathies Herein, a non-viral biomimetic system to directly reprogram CFs for cardiac regeneration after myocardial injury was developed by coating FH peptide-modified neutrophil-mimicking membranes on mesoporous silicon nanoparticles (MSNs) loaded with microRNA1, 133, 208, and 499 (miR Combo). +lncRNA target 34293593 hsa-mir-543 Breast Neoplasms BC tissue samples were collected from 26 patients, and qRT-PCR and western blotting were performed to evaluate the levels of miR-543 and VCAN. We found that miR-543 inhibited BC cell viability, proliferation, migration, and invasion by repressing the expression of VCAN. +circulation_biomarker_diagnosis_ns 34293021 hsa-mir-210 Diabetic Foot RESULTS: The HIF-1alpha expression decreased in DFU patients with increased miR-210 expression in both circulation and tissue biopsies. +genetics_knock down_promote 34292880 hsa-mir-205 Breast Neoplasms knockdown or E2F1-overexpressing BCCs. +lncRNA target 34292663 hsa-mir-520g Colorectal Neoplasms Circ_0000317 represses CRC progression by targeting miR-520g and modulating HOXD10 expression. +genetics_overexpression_promote 34292652 hsa-mir-671 Thyroid Cancer, Papillary 5p overexpression on papillary thyroid carcinoma cell growth. +transcription factor target 34291866 hsa-mir-145 Glaucoma 5p inhibited the apoptosis of RGCs via TRIM2-mediated activation of the PI3K/AKT signaling pathway in NMDA-induced glaucoma. +lncRNA target 34290981 hsa-mir-637 Cholangiocarcinoma In all, HOTTIP modulates the sensitivity to CG in CCA through the HOTTIP/miR-637/LASP1 regulatory axis, providing a new opportunities for CCA treatment. +genetics_GWAS 34290767 hsa-mir-26b Hypertrophy, Left Ventricular Compared with high miR-26b level group, interventricular septal thickness (IVST), left ventricular posterior wall thickness (LVPWT), left ventricular mass index (LVMI) and number of LVH cases in low miR-26b level group significantly increased (P<0.05), and mitral ratio of peak early to late diastolic filling velocity (E/A) decreased (P<0.05). +genetics_overexpression_promote 34290668 hsa-mir-545 Thyroid Neoplasms The overexpression of SLC7A11 or the inhibitor of miR +circulation_biomarker_diagnosis_up 34290498 hsa-mir-151a Osteoporosis, Postmenopausal Ovariectomized (OVX) rats were treated with antago microRNA-151a-3p or antago NC, and then serum and lumbar vertebrae were collected for ELISA and bone histomorphology analysis. +other 34290266 hsa-mir-513b Intracranial Aneurysm Quantitative real-time polymerase chain reaction was used to measure the expression of hsa-miR-513b-5p, COL1A1, COL1A2, TNF-alpha, IL-6, MMP2, MMP3, MMP9 and TIMP4 in patients with ruptured IA (RA) (n = 100), patients with un-ruptured IA (UA) (n = 100), and controls (n = 100). +other 34289913 hsa-mir-146a Chagas Disease The relevant finding was that miR-146a was up-regulated in each sample in both phases; therefore, this miRNA could be a possible candidate biomarker in Chagas disease. +circulation_biomarker_prognosis_ns 34289890 hsa-mir-20 Lung Neoplasms CONCLUSION: Overall our data provide a new perspective on the pro-tumorigenic role of circulating EVs in high risk smokers and highlight the significance of miR +other 34289870 hsa-mir-451a Sarcopenia RESULTS The SNAP-25 rs363050 AA genotype was significantly more common in sarcopenic patients compared to HC (pc=0.01); miR-451a was significantly up-regulated in these patients before rehabilitation. +target gene 34289837 hsa-mir-198 Carcinoma, Renal Cell miR-198 inhibits the progression of renal cell carcinoma by targeting BIRC5. +lncRNA target 34289835 hsa-mir-612 Thyroid Cancer, Papillary CONCLUSIONS: This study first demonstrates FER1L4 plays an oncogenic role in PTC via a FER1L4-miRCDH4 axis and may provide new therapeutic and diagnostic targets for PTC. +transcription factor target 34289832 hsa-mir-29a Endometrial Neoplasms miR-29a-3p inhibited CDC42/PAK1 signaling pathway activity in EC cells (P < 0.01). +lncRNA target 34289745 hsa-mir-141 Sepsis CONCLUSION: MiR-141 could decrease inflammatory response and reduce myocardial cell apoptosis by targeting DAPK1, thereby playing the promising protective role in SIC. +lncRNA target 34289745 hsa-mir-141 Cardiomyopathies CONCLUSION: MiR-141 could decrease inflammatory response and reduce myocardial cell apoptosis by targeting DAPK1, thereby playing the promising protective role in SIC. +circulation_biomarker_diagnosis_ns 34289701 hsa-mir-499 Sleep Apnea, Obstructive Materials & methods: Plasmatic levels of miR +circulation_biomarker_diagnosis_ns 34289701 hsa-mir-499a Sleep Apnea, Obstructive Materials & methods: Plasmatic levels of miR +lncRNA target 34289570 hsa-mir-1258 Esophageal Squamous Cell Carcinoma ASB16-AS1 promotes the proliferation, migration and invasion of esophageal cancer cells by targeting miR-1258. +other 34289553 hsa-mir-146b Thyroid Cancer, Papillary There are many markers of PTC, such as murine sarcoma viral oncogene homolog B1 (BRAF), telomerase reverse transcriptase, Ki-67, microRNA-146b, PDZ and LIM domain 5 (PDLIM5). +lncRNA target 34289449 hsa-mir-195 Triple Negative Breast Neoplasms In conclusion, formononetin alleviated TNBC malignancy by suppressing lncRNA AFAP1-AS1-miR-195/miR-545 axis, suggesting that molecular targets combined with traditional Chinese medicine could yield significant clinical benefits in TNBC. +lncRNA target 34289449 hsa-mir-545 Triple Negative Breast Neoplasms In conclusion, formononetin alleviated TNBC malignancy by suppressing lncRNA AFAP1-AS1-miR-195/miR-545 axis, suggesting that molecular targets combined with traditional Chinese medicine could yield significant clinical benefits in TNBC. +genetics_knock down_promote 34288826 hsa-mir-106b Cerebral Hemorrhage, Traumatic Over-expression of miR-106b-5p reversed the effects of H19 on cell viability and ferroptosis in BMVECs. Knockdown of H19 promoted cell proliferation and suppressed BMVECs ferroptosis by regulating the miR-106b-5p/ACSL4 axis. +circulation_biomarker_diagnosis_up 34288824 hsa-mir-488 Atherosclerosis Serum expression of miR-488 in AS patients was higher than that in healthy controls. +genetics_overexpression_promote 34288823 hsa-mir-506 Colorectal Neoplasms Overexpressing miR +circRNA target 34288822 hsa-mir-525 Breast Neoplasms 5p/SKA1 via the Notch and Wnt pathway, providing a potential therapeutic target for patients with OX-resistant BC. +circRNA target 34288821 hsa-mir-641 Urinary Bladder Neoplasms Our findings indicated that circSETD3 acted as a vital tumor suppressor in BLCA via regulating the miR-641/PTEN axis. +genetics_knock down_promote 34288816 hsa-mir-502 Ovarian Neoplasms 5p-GINS2 axis was detected by assessing cell proliferation, migration, and apoptosis levels, such as caspase-3 activity and caspase-3 protein expression, in the OC cell lines CaOV3 and SKOV3, respectively. +lncRNA target 34288815 hsa-mir-429 Melanoma To identify how circular RNA circRNA_0082835 impacts melanoma cells and lymphatic metastasis to observe whether it exerts effects through its action mechanism of sponging microRNA miR-429. In conclusion, circRNA_0082835 sponges miR-429 to affect the anti-tumor effect of miR-429 in primary melanoma and lymphatic metastasis. +genetics_knock down_suppress 34288812 hsa-mir-17 Colorectal Neoplasms 5p inhibitor could reverse the role of PAUPAR knockdown on the malignant phenotypes of CRC cells. +lncRNA target 34288804 hsa-mir-579 Squamous Cell Carcinoma of Head and Neck Collectively, our study uncovered a functional role of circBCL11B/miR-579/LASP1 axis in OSCC, implying that targeting these molecules could be an intervention approach in OSCC treatment. +other 34288803 hsa-mir-210 Glioma A nine-EMT-related lncRNAs (HAR1A, LINC00641, LINC00900, MIR210HG, MIR22HG, PVT1, SLC25A21-AS1, SNAI3-AS1, and SNHG18) signature was identified in patients with glioma. +other 34288803 hsa-mir-22 Glioma A nine-EMT-related lncRNAs (HAR1A, LINC00641, LINC00900, MIR210HG, MIR22HG, PVT1, SLC25A21-AS1, SNAI3-AS1, and SNHG18) signature was identified in patients with glioma. +genetics_knock down_promote 34288800 hsa-mir-211 Pneumonia, Mycoplasma In conclusion, the knockdown of PROX1-AS1 promoted the cell morbidity of the trophoblast cells by modulating the miR +circulation_biomarker_prognosis_ns 34288799 hsa-mir-455 Neonatal Sepsis The expression of serum miR +other 34288535 hsa-mir-223 Hepatitis B, Chronic 3p identified in this study indicated a relevance to the underlying biological basis of SSDHS, and may provide scientific basis for the application of same TCM prescription in CHB and CG. +other 34288535 hsa-mir-223 Chronic Gastritis 3p identified in this study indicated a relevance to the underlying biological basis of SSDHS, and may provide scientific basis for the application of same TCM prescription in CHB and CG. +other 34288535 hsa-mir-483 Chronic Gastritis 3p identified in this study indicated a relevance to the underlying biological basis of SSDHS, and may provide scientific basis for the application of same TCM prescription in CHB and CG. +other 34288535 hsa-mir-483 Hepatitis B, Chronic 3p identified in this study indicated a relevance to the underlying biological basis of SSDHS, and may provide scientific basis for the application of same TCM prescription in CHB and CG. +lncRNA target 34288494 hsa-mir-181a Colorectal Neoplasms OBJECTIVES: It is reported that long non-coding RNA (lncRNA) colorectal neoplasia differentially expressed (CRNDE) targets microRNA (miR)-33a, miR-181a and miR-495 to regulate inflammation process, while few studies report their clinical application for paediatric asthma management. +lncRNA target 34288494 hsa-mir-181a Asthma OBJECTIVES: It is reported that long non-coding RNA (lncRNA) colorectal neoplasia differentially expressed (CRNDE) targets microRNA (miR)-33a, miR-181a and miR-495 to regulate inflammation process, while few studies report their clinical application for paediatric asthma management. +lncRNA target 34288494 hsa-mir-495 Colorectal Neoplasms OBJECTIVES: It is reported that long non-coding RNA (lncRNA) colorectal neoplasia differentially expressed (CRNDE) targets microRNA (miR)-33a, miR-181a and miR-495 to regulate inflammation process, while few studies report their clinical application for paediatric asthma management. +lncRNA target 34288494 hsa-mir-495 Asthma OBJECTIVES: It is reported that long non-coding RNA (lncRNA) colorectal neoplasia differentially expressed (CRNDE) targets microRNA (miR)-33a, miR-181a and miR-495 to regulate inflammation process, while few studies report their clinical application for paediatric asthma management. +lncRNA target 34288494 hsa-mir-33a Colorectal Neoplasms OBJECTIVES: It is reported that long non-coding RNA (lncRNA) colorectal neoplasia differentially expressed (CRNDE) targets microRNA (miR)-33a, miR-181a and miR-495 to regulate inflammation process, while few studies report their clinical application for paediatric asthma management. +lncRNA target 34288494 hsa-mir-33a Asthma OBJECTIVES: It is reported that long non-coding RNA (lncRNA) colorectal neoplasia differentially expressed (CRNDE) targets microRNA (miR)-33a, miR-181a and miR-495 to regulate inflammation process, while few studies report their clinical application for paediatric asthma management. +other 34288395 hsa-mir-4459 Colorectal Neoplasms 5p and miR-4459 - exhibited increased levels at all CRC stages. +other 34288395 hsa-mir-1207 Colorectal Neoplasms 5p and miR-4459 - exhibited increased levels at all CRC stages. +other 34288395 hsa-mir-1225 Colorectal Neoplasms 5p and miR-4459 - exhibited increased levels at all CRC stages. +lncRNA target 34288373 hsa-mir-148a Ovarian Neoplasms Furthermore, we discovered that PVT1 up-regulated the expression of AGO1 and thus regulated the transforming growth factor-beta (TGF-beta) pathway to promote ovarian cancer progression through sponging miR-148a-3p. Taken together, the present study reveals that PVT1/miR-148a/AGO1 axis plays an important role in the progression of ovarian cancer and emphasize the potential as a target of value for ovarian cancer therapy. +genetics_GWAS 34288281 hsa-mir-193a Colorectal Neoplasms Addition of miR-193a-3p and/or modulation of proteins involved in the miR-193a-3p-mediated pathway, such as Mcl1, to EGFR/BRAF/MEK inhibition may be a potential therapeutic strategy against BRAF-mutated CRC. +genetics_knock down_promote 34288231 hsa-mir-21 Ovarian Neoplasms 5p derived from DDP-resistant SKOV3 OC cells promotes glycolysis and inhibits chemosensitivity of its progenitor SKOV3 cells by targeting PDHA1. +other 34287793 hsa-mir-183 Anovulation 96-182 cluster/FoxO1 may be a potential pathway for regulating follicular atresia and female reproduction. +lncRNA target 34287578 hsa-mir-326 Squamous Cell Carcinoma of Head and Neck Furthermore, circDHTKD1 contributed to OSCC progression in vivo via the miR-326/GAB1 axis. +other 34287356 hsa-mir-223 Tuberous Sclerosis 1 5p) that are significantly increased in epileptogenic tubers and contain nucleic acid motifs that activate toll-like receptors (TLR7/8), initiating a neuroinflammatory cascade. +other 34287356 hsa-mir-142 Tuberous Sclerosis 1 5p) that are significantly increased in epileptogenic tubers and contain nucleic acid motifs that activate toll-like receptors (TLR7/8), initiating a neuroinflammatory cascade. +other 34287356 hsa-mir-21 Tuberous Sclerosis 1 5p) that are significantly increased in epileptogenic tubers and contain nucleic acid motifs that activate toll-like receptors (TLR7/8), initiating a neuroinflammatory cascade. +lncRNA target 34287099 hsa-mir-532 Carcinoma, Renal Cell 3p could attenuate the viability, migration and invasion of ccRCC cells by targeting TROAP. +lncRNA target 34287088 hsa-mir-511 Hepatic Veno-Occlusive Disease 3p aggravates HSOS by activating the Hedgehog signaling pathway through targeting Ptch1, and miR +lncRNA target 34287083 hsa-mir-7 Cataract, Congenital Zonular, with Sutural Opacities The expression of the apoptosis marker genes in CPMs was significantly reduced after transfection with miR-7 inhibitor. +lncRNA target 34287042 hsa-mir-24 Influenza, Human Furthermore, lncRNA IFITM4P was identified as a target of miR3p and acts as a ceRNA to inhibit the replication of IAV through regulating the mRNA levels of IFITM1, IFITM2, and IFITM3. +circulation_biomarker_diagnosis_up 34287021 hsa-mir-424 Carcinoma, Hepatocellular Conclusions: The data suggest that serum miR-424 may represent a biomarker in early detection of HCC. +genetics_knock down_promote 34286520 hsa-mir-363 Colorectal Neoplasms 3p, and the inhibitory effect of FEZF1-AS1 knockdown on CRC progression could also be eliminated by PRRX1 overexpression. +genetics_knock down_suppress 34286518 hsa-mir-15b Carcinoma, Non-Small-Cell Lung CONCLUSIONS: Knockdown of miR-15b partially reversed cisplatin resistance in NSCLC cells through the GSK-3beta/MCL-1 pathway. +lncRNA target 34286514 hsa-mir-129 Carcinoma, Hepatocellular CONCLUSIONS: Our findings demonstrated that PCGEM1 modulated oxaliplatin resistance by targeting the miR +lncRNA target 34286462 hsa-mir-7 Intracranial Aneurysm CONCLUSIONS: These results suggested that ANRIL affects VSMC proliferation and apoptosis via regulation of the miR-7/FGF2 pathway in IA, which provided a potential novel strategy for the treatment of IA. +other 34286132 hsa-mir-664a Autism Spectrum Disorder 5p, and miR-664a-3p in ASD children suggest that these miRNAs can be considered good candidates for non-invasive molecular biomarkers in the study of ASD patients. +other 34286132 hsa-mir-197 Autism Spectrum Disorder 5p, and miR-664a-3p in ASD children suggest that these miRNAs can be considered good candidates for non-invasive molecular biomarkers in the study of ASD patients. +other 34286132 hsa-mir-500 Autism Spectrum Disorder 5p, and miR-664a-3p in ASD children suggest that these miRNAs can be considered good candidates for non-invasive molecular biomarkers in the study of ASD patients. +other 34286132 hsa-mir-424 Autism Spectrum Disorder 5p, and miR-664a-3p in ASD children suggest that these miRNAs can be considered good candidates for non-invasive molecular biomarkers in the study of ASD patients. +other 34286132 hsa-mir-500a Autism Spectrum Disorder 5p, and miR-664a-3p in ASD children suggest that these miRNAs can be considered good candidates for non-invasive molecular biomarkers in the study of ASD patients. +circulation_biomarker_diagnosis_ns 34285721 hsa-mir-1246 Liposarcoma The present analysis of tissue and serum miRNA expression in osteosarcoma, Ewing's sarcoma and dedifferentiated liposarcoma (DDLPS) identified miR-1246, -4532, -4454, 5p and -6126 as biomarkers for DDLPS. +other 34285579 hsa-mir-148b Retinoblastoma CONCLUSION: LncRNA NEAT1 can mediate miR-148b-3p/ROCK1 axis to weaken the proliferation and invasion of retinoblastoma. +therapeutic target 34285578 hsa-mir-1286 Breast Neoplasms Silencing of circHIPK3 Sensitizes Paclitaxel-Resistant Breast Cancer Cells to Chemotherapy by Regulating HK2 Through Targeting miR-1286. +other 34285562 hsa-mir-3690 Carcinoma, Hepatocellular CONCLUSION: We propose a risk score based on miR3p and miR-3690 that may be useful as a prognostic marker to predict HCC recurrence after LT. +other 34285562 hsa-mir-3200 Carcinoma, Hepatocellular CONCLUSION: We propose a risk score based on miR3p and miR-3690 that may be useful as a prognostic marker to predict HCC recurrence after LT. +lncRNA target 34285545 hsa-let-7c Urethral Stricture CONCLUSION: These results support a role for let-7c-containing Exo-MSCs(IL-1beta) in reducing urethral stricture via inhibition of PAK1-NF-kappaB signaling, M2 macrophage polarization, and differentiation of urethral myofibroblasts. +lncRNA target 34285285 hsa-mir-486 Multiple Endocrine Neoplasia Type 1 The latter included the known suppressor miRNA miR3p, which was chosen for transfection in human adrenocortical carcinoma cell lines H295R and SW13. +lncRNA target 34285285 hsa-mir-486 Adrenocortical Carcinoma The latter included the known suppressor miRNA miR3p, which was chosen for transfection in human adrenocortical carcinoma cell lines H295R and SW13. +circRNA target 34284793 hsa-mir-1296 Uterine Cervical Neoplasms Silencing hsa_circ_0000520 inhibited cervical cancer cell proliferation and promoted the inhibitory effects of miR-1296 on CDK2, thereby blocking cell cycle progression and promoting apoptosis. +other 34284726 hsa-mir-206 Osteoporosis Therefore, the present study aimed to investigate the effects of resistance-type training using elastic band-induced changes of myomiRs (i.e., miR-206 and miR-133), vitamin D, CTX-I, ALP, and FRAX(R) score in elderly women with osteosarcopenic obesity (OSO). +other 34284726 hsa-mir-133 Osteoporosis Therefore, the present study aimed to investigate the effects of resistance-type training using elastic band-induced changes of myomiRs (i.e., miR-206 and miR-133), vitamin D, CTX-I, ALP, and FRAX(R) score in elderly women with osteosarcopenic obesity (OSO). +other 34284726 hsa-mir-133 Obesity, Osteosarcopenic Therefore, the present study aimed to investigate the effects of resistance-type training using elastic band-induced changes of myomiRs (i.e., miR-206 and miR-133), vitamin D, CTX-I, ALP, and FRAX(R) score in elderly women with osteosarcopenic obesity (OSO). +other 34284726 hsa-mir-206 Obesity, Osteosarcopenic Therefore, the present study aimed to investigate the effects of resistance-type training using elastic band-induced changes of myomiRs (i.e., miR-206 and miR-133), vitamin D, CTX-I, ALP, and FRAX(R) score in elderly women with osteosarcopenic obesity (OSO). +other 34284702 hsa-mir-509 Breast Neoplasms In this study, the association of rs73092672 which is located within the FHIT gene and the 3'UTR of hsa-miR5p with the susceptibility to breast cancer risk has been studied in the Iranian population. +circulation_biomarker_diagnosis_up 34284684 hsa-let-7a Pre-Eclampsia RESULTS: The relative expression of let-7a in the SPE group was significantly lower than that in the control group (0.06 /- 0.02 versus 0.25 /- 0.04, p < .05); the expression of TNF-alphamRNA in the SPE group was significantly higher than that in the control group (0.48 /- 0.04 versus 0.17 /- 0.03, p < .05); TNF-alpha protein expression was significantly increased in the SPE group (1.09 /- 0.12 versus 0.56 /- 0.03, p < .05); let-7a and TNF-alpha were significantly negatively correlated (r = -0.41, p < .05); the blood pressure and birth weight of the pregnant women in the SPE group and the control group were significantly different [systolic blood pressure (164.27 /- 4.62) mmHg versus (125.01 /- 2.23)] mmHg, diastolic blood pressure (109.24 /- 2.97) mmHg versus (75.94 /- 2.74) mmHg, neonatal birth weight (2507.02 /- 161.46) g versus (3592.12 /- 153.05) g, p < .05]; the expression of TNF-alpha in placental tissue of SPE group was significantly positively correlated with systolic and diastolic blood pressure (r = 0.93 and 0.89, p < .05). +transcription factor target 34284540 hsa-mir-125a Brain Ischemia These data supported the fact that miR-125a-5p silencing protects against cerebral ischemia-induced injury by targeting IGFBP3. +genetics_overexpression_promote 34284144 hsa-mir-509 Colonic Neoplasms 3-5p expression reduced in CC, and its overexpression inhibited the proliferation, migration and invasion of CC cells. +genetics_overexpression_suppress 34284141 hsa-mir-599 Urinary Bladder Neoplasms RESULTS: MiR-599 was significantly downregulated in the BC, and miR-599 overexpression impeded the malignancy of BC cells by regulating proliferation, migration, invasion and apoptosis. +genetics_overexpression_promote 34284078 hsa-mir-376c Stomach Neoplasms WNT2b silencing reduced the effect of miR-376c-3p inhibition while WNT2b overexpression mitigated that of miR-376c-3p promotion on GC cell growth. +transcription factor target 34284075 hsa-mir-26b Subarachnoid Hemorrhage Moreover, injection of miR-26b-5p inhibitor resulted in increased MAT2A and pathway protein expression, increased inflammatory mediators, and aggravated neurological symptoms in the brain tissues of SAH rats. +transcription factor target 34284075 hsa-mir-26b Brain Injuries Moreover, injection of miR-26b-5p inhibitor resulted in increased MAT2A and pathway protein expression, increased inflammatory mediators, and aggravated neurological symptoms in the brain tissues of SAH rats. +transcription factor target 34283251 hsa-mir-452 Colitis These findings suggest that MIR452 is a promising therapeutic target in the treatment of cancer and colitis. +transcription factor target 34283251 hsa-mir-452 Colorectal Neoplasms These findings suggest that MIR452 is a promising therapeutic target in the treatment of cancer and colitis. +other 34283216 hsa-mir-96 Elephantiasis We show that two rice genes, OsGRF4 (GROWTH REGULATING FACTOR 4) and OsGRF8 carrying in-frame mutants with disruption of the miR396 recognition sites, escape from miR396-mediated post-transcriptional silencing, resulting in enlarged grain size and increase in brown planthopper (BPH) resistance, in their respective transgenic rice lines. +transcription factor target 34283087 hsa-mir-23a Ovarian Neoplasms, High-Grade Serous RT-qPCR data confirmed upregulation of miR-23a-3p in tumors from chemoresistant HGSOC patients and its significant association with shorter PFS. These results highlight miR-23a-3p as a potential biomarker for HGSOC platinum response and prognosis and the miR23a-3p/APAF1 axis as a possible target to overcome platinum-resistance. +therapeutic target 34283053 hsa-mir-92b Colorectal Neoplasms miR-92b-3p Regulates Cell Cycle and Apoptosis by Targeting CDKN1C, Thereby Affecting the Sensitivity of Colorectal Cancer Cells to Chemotherapeutic Drugs. +lncRNA target 34282711 hsa-mir-19b Squamous Cell Carcinoma of Head and Neck Then, the function of the SNHG20/miR-19b-3p/RAB14 axis in OSCC was explored. LncRNA SNHG20 affects cell proliferation, migration, and invasion via the miR-19b-3p/RAB14 axis in OSCC. +other 34282692 hsa-mir-146a Osteoarthritis We found that CALML3-AS1 was downregulated, while miR-146a was upregulated in osteoarthritis. +lncRNA target 34282279 hsa-mir-20a Leukemia, Myeloid, Acute In addition, HOTAIR upregulated WT1 expression by targeting miR-20a-5p, and inhibition of miR-20a-5p reversed the regulation of Adriamycin resistance by curcumin in AML cells. In short, curcumin suppressed the proliferation and migration, blocked the cell cycle progression of AML cells, and sensitized AML cells to Adriamycin by regulating the HOTAIR/miR-20a-5p/WT1 axis. +other 34282172 hsa-mir-151a Non-alcoholic Fatty Liver Disease 5p, and miR-4449) showed significant area under the receiver operating characteristic curve (AUC) values for NASH diagnosis. +other 34282172 hsa-mir-4449 Non-alcoholic Fatty Liver Disease 5p, and miR-4449) showed significant area under the receiver operating characteristic curve (AUC) values for NASH diagnosis. +other 34282172 hsa-mir-21 Non-alcoholic Fatty Liver Disease 5p, and miR-4449) showed significant area under the receiver operating characteristic curve (AUC) values for NASH diagnosis. +lncRNA target 34282122 hsa-mir-451a Lupus Erythematosus, Systemic The findings revealed a novel mechanism linking IRF-8/miR-451a to M-MDSC differentiation via the AMPK/mTOR signal pathway during lupus development. +lncRNA target 34281839 hsa-let-7a Colorectal Neoplasms CONCLUSION: Let-7a inhibited the growth and metastasis of colonic mucinous adenocarcinoma cells, at least partially, by regulating the TGF-beta/Smad signaling pathway. +circulation_biomarker_prognosis_ns 34281802 hsa-mir-875 Breast Neoplasms And serum miR-875 could screen breast cancer patients from healthy individuals. +target gene 34281530 hsa-mir-216b Breast Neoplasms CircFBXL5 promotes the 5-FU resistance of breast cancer via modulating miR-216b/HMGA2 axis. +lncRNA target 34281459 hsa-mir-514b Esophageal Neoplasms Taken together, our data support the notion that lncRNA DDX11-AS1 promotes the progression of ESCA through miR-514b-3p/RBX1 axis. +epigenetics 34280597 hsa-mir-195 Osteoarthritis 5p through methylation to suppress LPS-induced apoptosis of chondrocytes, thereby suppressing OA. +circulation_biomarker_prognosis_ns 34280472 hsa-mir-425 Oropharyngeal Neoplasms CONCLUSIONS Serum expression levels of miR +circulation_biomarker_prognosis_ns 34280472 hsa-mir-185 Xerostomia CONCLUSIONS Serum expression levels of miR +circulation_biomarker_prognosis_ns 34280472 hsa-mir-425 Xerostomia CONCLUSIONS Serum expression levels of miR +circulation_biomarker_prognosis_ns 34280472 hsa-mir-185 Oropharyngeal Neoplasms CONCLUSIONS Serum expression levels of miR +circRNA target 34280452 hsa-mir-375 Hypoxia-Ischemia, Brain 3p may be a key regulatory molecule in the pineal gland following HIBD, and targeting of miR +circulation_biomarker_diagnosis_up 34279788 hsa-mir-485 Parkinson Disease 3p was significantly up-regulated in serum of PD patients compared with that in both Alzheimer's disease (AD) and healthy cases, and had diagnostic accuracy for PD screening. +exosome 34279157 hsa-mir-143 Carcinoma, Hepatocellular RESULTS: Exosomal miR +lncRNA target 34278507 hsa-mir-26b Breast Neoplasms Functional analysis in human breast cancer cell lines demonstrated that MALAT1 modulated breast cancer cell tumorigenicity by acting as a competing endogenous lncRNA (ceRNA) to regulate ST8SIA4 levels by sponging miR26a/26b. The identification of the MALAT1/miR26a/26b/ST8SIA4 axis which contributes to breast cancer progression may constitute a potential new therapeutic target. +lncRNA target 34278507 hsa-mir-26a Breast Neoplasms Functional analysis in human breast cancer cell lines demonstrated that MALAT1 modulated breast cancer cell tumorigenicity by acting as a competing endogenous lncRNA (ceRNA) to regulate ST8SIA4 levels by sponging miR26a/26b. The identification of the MALAT1/miR26a/26b/ST8SIA4 axis which contributes to breast cancer progression may constitute a potential new therapeutic target. +genetics_knock down_suppress 34278506 hsa-mir-367 Prostatic Neoplasms The overexpression of miR3673p or the knockdown of Rab23 inhibited the proliferation, invasion, and metastasis of prostate cancer cells. +lncRNA target 34278505 hsa-mir-106b Carcinoma, Non-Small-Cell Lung The aforementioned results indicated that TMEM100 induced cell apoptosis and inhibited cell survival by serving as a tumour suppressor and that miR106bmitigatedTMEM100 expression defined a potentially oncogenic pathway in NSCLC. +genetics_knock down_promote 34278482 hsa-mir-485 Carcinoma, Endometrioid The tumor suppressing effect of LINC01224knockdown on EC progression was partly rescued by treatment with miR4855p inhibitor. +other 34278472 hsa-mir-613 Rolandic Epilepsy, Mental Retardation, and Speech Dyspraxia, X-Linked However, the mechanism underlying the miR36133pmediated apoptosis of HSexposed endothelial cells remains unclear. In conclusion, the miR36133p/MAP3K2/p38/caspase3 pathway may serve an indispensable role in regulating the progression of apoptosis, indicating a regulatory role of miR36133p in the pathophysiology of HSexposed endothelial cells. +lncRNA target 34278471 hsa-mir-29a Norrie disease Furthermore, SPARC could induce the formation of EMT in 16HBE cells in vitro and this was directly targeted by miR29a3p and mediated by pERK, suggesting that miR29a3p may participate in the airway remodeling of NA. +genetics_overexpression_promote 34278459 hsa-mir-135b Multiple Myeloma Overexpressing DANCR or knocking down miR135b5p reduced the viability of the MM cells, as well as restrained MM cells from migrating and invading. +genetics_overexpression_promote 34278448 hsa-mir-25 Glioblastoma By contrast, miR253p overexpression facilitated the proliferation and TMZ resistance of sensitive GBM cells. +genetics_knock down_promote 34278445 hsa-mir-221 Glioma The present study aimed to verify the activity on glioblastoma cancer cell lines of one of the most active compounds tested, corresponding to 2(3', 4', 5'trimethoxyanilino)3cyano/alkoxycarbonyl6substitu 5,6,7tetrahydrothiene[2,3c] pyridine (compound 3b), used in combination with an antimiR2213p PNA, already demonstrated to be able to induce high levels of apoptosis. To the best of our knowledge, the results obtained herein demonstrate for the first time a 'combination therapy' performed by the combined use of a PNA targeting miR221 and the tetrahydrothiene[2,3c]pyridine derivative 3b, supporting the concept that the combined treatment of GBM cells with a PNA against a specific upregulated oncomiRNA (in the present study a PNA targeting miR2213p was used) and antitubulin agents (in the present study derivative 3b was used) is an encouraging strategy which may be used to enhance the efficacy of anticancer therapies and at the same time, to reduce sideeffects. +genetics_overexpression_promote 34278444 hsa-mir-431 Nasopharyngeal Carcinoma Overexpression of PBOV1 neutralized the miR431mediated suppression of NPC progression. +circulation_biomarker_prognosis_ns 34277865 hsa-mir-15b Leukemia, Lymphocytic, Chronic, B-Cell The expression levels of miR-15b and miR-195 were significantly higher in the plasma of patients with B-CLL compared to the healthy individuals (91.6, p= 0.001) (169, p= 0.001). CONCLUSION: Both miR-15b and miR-195, have the potential to function as novel and non-invasive biomarkers in the diagnosis and prognosis of patients with B-CLL. +circulation_biomarker_prognosis_ns 34277865 hsa-mir-195 Leukemia, Lymphocytic, Chronic, B-Cell The expression levels of miR-15b and miR-195 were significantly higher in the plasma of patients with B-CLL compared to the healthy individuals (91.6, p= 0.001) (169, p= 0.001). CONCLUSION: Both miR-15b and miR-195, have the potential to function as novel and non-invasive biomarkers in the diagnosis and prognosis of patients with B-CLL. +target gene 34277808 hsa-mir-218 Breast Neoplasms Tumor protein D52 promotes breast cancer proliferation and migration via the long non-coding RNA NEAT1/microRNA-218-5p axis. +genetics_overexpression_promote 34277805 hsa-mir-21 Atherosclerosis CONCLUSIONS: In summary, LncRNA-TCONS_00034812 is upregulated in atherosclerotic samples, and its overexpression upregulates miR-21 through methylation in human aortic smooth muscle cells (HAOSMCs). +target gene 34277782 hsa-let-7c Lung Neoplasms Lin28A promotes the proliferation and stemness of lung cancer cells via the activation of mitogen-activated protein kinase pathway dependent on microRNA let-7c. +other 34277765 hsa-mir-205 Diabetes Mellitus RESULTS: In the hippocampus of STZ-treated diabetic rats, lncRNA Vof-16, and Gnb3 mRNA were significantly upregulated and silicon analysis showed that Vof-16 and miR-205 share the same miRNA response element (MRE). +circulation_biomarker_diagnosis_down 34277703 hsa-mir-124 Ischemic Stroke 3p in EVs was negatively correlated with serum pro-inflammatory cytokines and the NIHSS (p < 0.05). +other 34277699 hsa-mir-497 Intervertebral disc disease 5p level was negatively proportional to HOXC13-AS expression in IDD specimens. +other 34277644 hsa-mir-10b Breast Neoplasms First, the miRNAs, miR-135, miR-203, miR-10b, miR-194, miR-886, and miR-124 were evaluated in bone metastatic tissues, relative to adjacent control tissue. miR-203 was significantly down-regulated while miR-10b was significantly up-regulated in bone metastasis. +other 34277644 hsa-mir-194 Breast Neoplasms Additionally, miR-135 was significantly differentially expressed in the primary lung cancer patients while miR-194 in primary breast cancer patients. +other 34277644 hsa-mir-135 Breast Neoplasms Additionally, miR-135 was significantly differentially expressed in the primary lung cancer patients while miR-194 in primary breast cancer patients. +other 34277644 hsa-mir-203 Breast Neoplasms First, the miRNAs, miR-135, miR-203, miR-10b, miR-194, miR-886, and miR-124 were evaluated in bone metastatic tissues, relative to adjacent control tissue. miR-203 was significantly down-regulated while miR-10b was significantly up-regulated in bone metastasis. +other 34277611 hsa-mir-495 Intervertebral disc disease CONCLUSION: Our findings identified a novel circSNHG5-miR3p axis responsible for IDD progression. +other 34277608 hsa-mir-223 Inflammation This study provided a regulation axis, EGF/miR-223/ISG15, and illustrated its regulation to gMEC apoptosis and inflammation. +transcription factor target 34277606 hsa-mir-17 Esophageal Neoplasms Notably, the gene most frequently associated with increased risk was HNRNPA2B1; in ESCA, the increased expression of this gene alone predicted poor prognosis by affecting tumor-promoting signaling pathways through miR +exosome 34277601 hsa-mir-630 Ovarian Neoplasms Tumor-Derived Extracellular Vesicles Promote Activation of Carcinoma-Associated Fibroblasts and Facilitate Invasion and Metastasis of Ovarian Cancer by Carrying miR-630. +other 34277600 hsa-mir-940 Sarcoma Afterward, we constructed an immune infiltration-related risk score model based on the expression of IRF1, MFNG, hsa-miR-940, and hsa-miR-378a-5p, presenting a promising performance in predicting the prognosis of patients with sarcoma. +other 34277600 hsa-mir-378a Sarcoma Afterward, we constructed an immune infiltration-related risk score model based on the expression of IRF1, MFNG, hsa-miR-940, and hsa-miR-378a-5p, presenting a promising performance in predicting the prognosis of patients with sarcoma. +target gene 34277424 hsa-mir-135b Esophageal Neoplasms Downregulation of miR-135b-5p Suppresses Progression of Esophageal Cancer and Contributes to the Effect of Cisplatin. +lncRNA target 34277412 hsa-mir-195 Adenocarcinoma of Lung In summary, this work elucidates that LINC00665 accelerates LUAD progression via the miR5p/MYCBP axis by acting as a competing endogenous RNA (ceRNA), suggesting that LINC00665 may represent a potential therapeutic target for clinical intervention of LUAD. +lncRNA target 34277403 hsa-mir-326 Prostatic Neoplasms The current results demonstrate that PCAT6 acted as a tumor activator in PCa progression by sponging miR-326 and increasing Hnrnpa2b1 expression and that the PCAT6/miR-326/Hnrnpa2b1 signaling might be a new therapeutic target for PCa. +target gene 34277059 hsa-mir-155 lung squamous cell carcinoma MicroRNA-155-5p promotes cell proliferation and invasion in lung squamous cell carcinoma through negative regulation of fibroblast growth factor 9 expression. +genetics_GWAS 34276910 hsa-mir-542 Hemophilia A 3p target the F8 gene and suppress the expression of FVIII protein, which may contribute to the development of HA without F8 mutations. +genetics_GWAS 34276910 hsa-mir-5581 Hemophilia A 3p target the F8 gene and suppress the expression of FVIII protein, which may contribute to the development of HA without F8 mutations. +lncRNA target 34276213 hsa-mir-30 Glioma miR-330 inhibition restored the malignancy of glioma cells. CONCLUSION: This study demonstrated that GABPB1-AS1 competitively bound to miR-330 and de-repressed ZNF367 expression, leading to activation of the cell cycle signaling pathway and the growth and metastasis of glioma cells. +other 34275894 hsa-mir-6089 Lymphoma, B-Cell, Diffuse CONCLUSIONS: MiR-3960, miR-6089 and miR5p can be used as the miRNA signature in DLBCL diagnosis. +other 34275894 hsa-mir-3960 Lymphoma, B-Cell, Diffuse CONCLUSIONS: MiR-3960, miR-6089 and miR5p can be used as the miRNA signature in DLBCL diagnosis. +other 34275894 hsa-mir-939 Lymphoma, B-Cell, Diffuse CONCLUSIONS: MiR-3960, miR-6089 and miR5p can be used as the miRNA signature in DLBCL diagnosis. +lncRNA target 34274947 hsa-mir-138 Stomach Neoplasms Furthermore, rescue assay further confirmed that UBE2CP3 mainly promoted GC progression through miR +genetics_overexpression_promote 34274936 hsa-mir-181b Eosinophilic enteropathy RESULTS: We found a significant upregulation of miR-181b, miR-490, and miR-21 in the EGN mucosa (overexpression 2times higher than controls). +other 34274936 hsa-mir-146a Eosinophilic enteropathy We observed a significant underexpression of miR-146a and miR-370 in atrophic/metaplastic gastritis (86 and 66% decrease, p = 0.008 and p = 0.001) and in EGN (89 and 62% reduction, p = 0.034 and p = 0.032) compared with controls. +other 34274936 hsa-mir-370 Gastritis, Atrophic We observed a significant underexpression of miR-146a and miR-370 in atrophic/metaplastic gastritis (86 and 66% decrease, p = 0.008 and p = 0.001) and in EGN (89 and 62% reduction, p = 0.034 and p = 0.032) compared with controls. +genetics_overexpression_promote 34274936 hsa-mir-490 Eosinophilic enteropathy RESULTS: We found a significant upregulation of miR-181b, miR-490, and miR-21 in the EGN mucosa (overexpression 2times higher than controls). +genetics_overexpression_promote 34274936 hsa-mir-21 Eosinophilic enteropathy RESULTS: We found a significant upregulation of miR-181b, miR-490, and miR-21 in the EGN mucosa (overexpression 2times higher than controls). +other 34274936 hsa-mir-370 Eosinophilic enteropathy We observed a significant underexpression of miR-146a and miR-370 in atrophic/metaplastic gastritis (86 and 66% decrease, p = 0.008 and p = 0.001) and in EGN (89 and 62% reduction, p = 0.034 and p = 0.032) compared with controls. +other 34274936 hsa-mir-146a Gastritis, Atrophic We observed a significant underexpression of miR-146a and miR-370 in atrophic/metaplastic gastritis (86 and 66% decrease, p = 0.008 and p = 0.001) and in EGN (89 and 62% reduction, p = 0.034 and p = 0.032) compared with controls. +genetics_overexpression_promote 34274936 hsa-mir-181 Eosinophilic enteropathy RESULTS: We found a significant upregulation of miR-181b, miR-490, and miR-21 in the EGN mucosa (overexpression 2times higher than controls). +other 34274912 hsa-mir-613 Pancreatic Carcinoma METHODS The expressions of CircCCT3 and miR-613 in pancreatic carcinoma tissues and cell lines were evaluated by quantitative real-time polymerase chain reaction (PCR). +genetics_overexpression_promote 34274651 hsa-mir-383 Melanoma 5p overexpression inhibited the proliferation, migration, and invasion of M14 and A375 cells. +genetics_overexpression_promote 34274607 hsa-mir-1224 Carcinoma, Renal Cell 3p, and overexpression of circ-EGLN3 reversed the repressive effects of miR +lncRNA target 34274471 hsa-let-7a Breast Neoplasms Our results showed that the inhibition of NANOG combined with Let-7a restoration contributed to significant decrease in malignant phenotypes and stemness feature of BC cells. +lncRNA target 34274194 hsa-mir-155 Oral Submucous Fibrosis CONCLUSION: Taken together, these findings indicate that miR-155 is implicated in the pathogenesis of oxidative stress-associated OSF, possibly through the regulation of RPTOR. +lncRNA target 34273985 hsa-mir-376c Holoprosencephaly 7 BACKGROUND: Our previous study shows that LINC01278 inhibits the malignant proliferation and invasion of papillary thyroid carcinoma (PTC) cells by regulating the miR-376c-3p/DNM3 axis. +lncRNA target 34273985 hsa-mir-376c Thyroid Cancer, Papillary BACKGROUND: Our previous study shows that LINC01278 inhibits the malignant proliferation and invasion of papillary thyroid carcinoma (PTC) cells by regulating the miR-376c-3p/DNM3 axis. +transcription factor target 34273914 hsa-mir-4661 Stomach Neoplasms 5p led to an increase in the expression of KDM5D while a decline in the expression of Mars2, which reduced the malignant behaviors of GC cells; however, the malignant behaviors of GC cells was restored after further inhibition of KDM5D. +circulation_biomarker_diagnosis_ns 34273912 hsa-mir-143 Mouth Neoplasms We explored these potential melanoma-specific exosomal miRNAs further and found that miR-143 and let-7b increased in primary, whereas miR-210, 708, 221, and 222 increased in metastatic site originated melanoma cells. Further analysis showed miR-143 and 221 significantly increased in plasma exosomes of metastatic melanoma patients. +lncRNA target 34273844 hsa-mir-493 Ischemic Stroke Conclusion MEG3 inhibits NSC proliferation of after IS via positive regulation of miR +lncRNA target 34273804 hsa-mir-335 Esophageal Squamous Cell Carcinoma In short, THAP9-AS1 accelerated cell growth of ESCC through sponging miR +circulation_biomarker_prognosis_ns 34273216 hsa-mir-491 Squamous Cell Carcinoma of Head and Neck 5p prediction model could serve as a blood-based diagnostic marker for LA-HNSCC. +transcription factor target 34273068 hsa-mir-222 Carcinoma, Hepatocellular Our findings suggest that miR3p might be a potential diagnostic and therapeutic target for HCC and HBV-related HCC. +other 34272987 hsa-mir-642a Cardiomyopathies In this study we aimed to evaluate the effect of miR-642a on sepsis-induced cardiac injury in vitro and explore the possible lncRNA-microRNA mechanism. +other 34272987 hsa-mir-642a Myocardial Injury In this study we aimed to evaluate the effect of miR-642a on sepsis-induced cardiac injury in vitro and explore the possible lncRNA-microRNA mechanism. +genetics_overexpression_promote 34272655 hsa-mir-575 Glioma In addition, the overexpression of miR-575 promoted the proliferation, migration, and invasion of glioma cells. +lncRNA target 34272387 hsa-mir-200c Breast Neoplasms Therefore, MIR200CHG can promote the proliferation, invasion, and drug resistance of breast cancer by interacting with and stabilizing YB-1, and has the potential to become a target for breast cancer treatment. +circulation_biomarker_prognosis_ns 34272079 hsa-mir-21 Sepsis CONCLUSION: In serum of patients with sepsis after burns, miR-21 expression reduces remarkably and miR-210 expression rises. +circulation_biomarker_prognosis_ns 34272079 hsa-mir-210 Sepsis CONCLUSION: In serum of patients with sepsis after burns, miR-21 expression reduces remarkably and miR-210 expression rises. +circulation_biomarker_prognosis_ns 34272079 hsa-mir-210 Burns CONCLUSION: In serum of patients with sepsis after burns, miR-21 expression reduces remarkably and miR-210 expression rises. +circulation_biomarker_prognosis_ns 34272079 hsa-mir-21 Burns CONCLUSION: In serum of patients with sepsis after burns, miR-21 expression reduces remarkably and miR-210 expression rises. +circRNA target 34271943 hsa-mir-195 Osteosarcoma CONCLUSIONS: Circ_001422 accelerates OS tumorigenesis and metastasis by modulating the miR5p/FGF2/PI3K/Akt axis, implying that circ_001422 can be therapeutically targeted to treat OS. +other 34271919 hsa-mir-195 Prostatic Neoplasms CONCLUSIONS: Taken together, our findings revealed a novel regulatory mechanism between circDPP4 and miR-195/cyclin D1 axis, and offered novel strategies for the treatment of PCa. +genetics_overexpression_promote 34271873 hsa-mir-148a Small Cell Lung Carcinoma In SCLC cells, MCM3AP-AS1 overexpression increased ROCK1 and promoted cancer cell invasion and migration, while miR-148a overexpression showed the opposite effects and attenuated the effects of MCM3AP-AS1 overexpression on ROCK1 expression and cell behaviors. CONCLUSIONS: MCM3AP-AS1 sponges miR-148a, thereby increasing SCLC cell invasion and migration via upregulating ROCK1 expression. +circulation_biomarker_diagnosis_up 34271014 hsa-mir-138 Sepsis METHODS: Serums of 22 patients with sepsis-induced myocardial injury (SIMI) and 24 healthy controls were collected to determine the expression levels of ZFAS1 and miR +other 34271004 hsa-mir-143 Hepatitis C We found consistent differences in terms of both miRNA and protein cargos: (i) antifibrogenic miR204-5p, miR181a-5p, miR143-3p, miR93-5p and miR122-5p were statistically underrepresented in T0 EVs compared to HD EVs, while miR204-5p and miR143-3p were statistically underrepresented in T6 EVs compared to HD EVs (p <0.05); (ii) proteomic analysis highlighted, in both T0 and T6, the modulation of several proteins with respect to HDs; among them, the fibrogenic protein DIAPH1 was upregulated (Log(2) fold change of 4.4). +other 34271004 hsa-mir-181a Hepatitis C We found consistent differences in terms of both miRNA and protein cargos: (i) antifibrogenic miR204-5p, miR181a-5p, miR143-3p, miR93-5p and miR122-5p were statistically underrepresented in T0 EVs compared to HD EVs, while miR204-5p and miR143-3p were statistically underrepresented in T6 EVs compared to HD EVs (p <0.05); (ii) proteomic analysis highlighted, in both T0 and T6, the modulation of several proteins with respect to HDs; among them, the fibrogenic protein DIAPH1 was upregulated (Log(2) fold change of 4.4). +other 34271004 hsa-mir-204 Hepatitis C We found consistent differences in terms of both miRNA and protein cargos: (i) antifibrogenic miR204-5p, miR181a-5p, miR143-3p, miR93-5p and miR122-5p were statistically underrepresented in T0 EVs compared to HD EVs, while miR204-5p and miR143-3p were statistically underrepresented in T6 EVs compared to HD EVs (p <0.05); (ii) proteomic analysis highlighted, in both T0 and T6, the modulation of several proteins with respect to HDs; among them, the fibrogenic protein DIAPH1 was upregulated (Log(2) fold change of 4.4). +other 34271004 hsa-mir-93 Hepatitis C We found consistent differences in terms of both miRNA and protein cargos: (i) antifibrogenic miR204-5p, miR181a-5p, miR143-3p, miR93-5p and miR122-5p were statistically underrepresented in T0 EVs compared to HD EVs, while miR204-5p and miR143-3p were statistically underrepresented in T6 EVs compared to HD EVs (p <0.05); (ii) proteomic analysis highlighted, in both T0 and T6, the modulation of several proteins with respect to HDs; among them, the fibrogenic protein DIAPH1 was upregulated (Log(2) fold change of 4.4). +other 34271004 hsa-mir-122 Hepatitis C We found consistent differences in terms of both miRNA and protein cargos: (i) antifibrogenic miR204-5p, miR181a-5p, miR143-3p, miR93-5p and miR122-5p were statistically underrepresented in T0 EVs compared to HD EVs, while miR204-5p and miR143-3p were statistically underrepresented in T6 EVs compared to HD EVs (p <0.05); (ii) proteomic analysis highlighted, in both T0 and T6, the modulation of several proteins with respect to HDs; among them, the fibrogenic protein DIAPH1 was upregulated (Log(2) fold change of 4.4). +lncRNA target 34270989 hsa-mir-199a Diabetes Mellitus In conclusion, our data demonstrated that miR-199a-3p/DDR1/p53/p21 signaling pathway was involved in endothelial senescence under diabetic conditions, and therapeutic targeting DDR1 would be exploited to inhibit endothelial senescence owing to high glucose exposure. +exosome 34270841 hsa-mir-1246 Cardiomegaly Our purpose here was to examine the relevance of exosomal microRNA-1246 (miR-1246) released from human umbilical cord mesenchymal stem cell (hucMSC) during CHF and the mechanism of action. +circRNA target 34270834 hsa-mir-762 Pneumonia, Mycoplasma CONCLUSION: In all, circ_0011460 suppressed HTR8/SVneo cell growth, migration, and invasion via miR-762/HTRA1 axis, suggesting a new insight into the pathogenesis of PE. +circulation_biomarker_prognosis_up 34270831 hsa-mir-21 Colorectal Neoplasms Furthermore, plasma miR21-5p can predict recurrence and PD after surgical resection. +transcription factor target 34270823 hsa-mir-181c GATA2 Deficiency These findings indicate that miR-181c expression is increased and MCL1 levels decreased in GATA2 deficiency cells, and that GATA2 represses miR-181c transcription. Increased miR-181c may contribute to elevated cell death and cytopenia in GATA2 deficiency potentially through down-regulation of MCL1. +transcription factor target 34270823 hsa-mir-181c Hematologic Diseases Increased miR-181c may contribute to elevated cell death and cytopenia in GATA2 deficiency potentially through down-regulation of MCL1. +other 34270733 hsa-mir-185 Adenocarcinoma of Lung In summary, our results show that LINC00205 contributes to LUAD malignancy by sponging miR5p, which provides new insight into LUAD progression. +genetics_knock down_promote 34270708 hsa-mir-339 Muscular Dystrophy, Duchenne Finally, knockdown of miR +lncRNA target 34270000 hsa-mir-517a Diabetes, Gestational The data suggested that lncRNA-SNX17 might promote the trophoblast proliferation through miR-517a/IGF-1 pathway and might play a role in the placentation of diabetic macrosomia. +transcription factor target 34269814 hsa-mir-138 Retinal Diseases CONCLUSIONS: SAL protected against hypoxia-induced HRMECs injury through regulating miR-138/ROBO4 axis, indicating the protective potential of SAL in retinopathies. +circRNA target 34269702 hsa-mir-599 Angelman Syndrome In conclusion, circ-USP9X silencing decreased ox-LDL-induced endothelial cell injury via the miR-599/CLIC4 axis, which offered a novel molecular mechanism to comprehend the pathology of AS. +transcription factor target 34269482 hsa-mir-140 Neuralgia 3p/JAG1 to alleviate NP. +genetics_overexpression_promote 34269397 hsa-mir-361 Diabetic Nephropathies Intriguingly, overexpression of DAPK1 in HG-stimulated podocytes muted miR +other 34269309 hsa-mir-1290 Breast Neoplasms Then, we detected the expression of the top-ranked miRNAs (miR-3662, miR1, miR-146a, miR-1290, and miR-29c) in sixty breast cancer patients and twenty healthy controls using quantitative real-time polymerase chain reaction. +other 34269309 hsa-mir-16-1 Breast Neoplasms Then, we detected the expression of the top-ranked miRNAs (miR-3662, miR1, miR-146a, miR-1290, and miR-29c) in sixty breast cancer patients and twenty healthy controls using quantitative real-time polymerase chain reaction. +other 34269309 hsa-mir-662 Breast Neoplasms Then, we detected the expression of the top-ranked miRNAs (miR-3662, miR1, miR-146a, miR-1290, and miR-29c) in sixty breast cancer patients and twenty healthy controls using quantitative real-time polymerase chain reaction. +other 34269309 hsa-mir-29c Breast Neoplasms Then, we detected the expression of the top-ranked miRNAs (miR-3662, miR1, miR-146a, miR-1290, and miR-29c) in sixty breast cancer patients and twenty healthy controls using quantitative real-time polymerase chain reaction. +other 34269309 hsa-mir-146a Breast Neoplasms Then, we detected the expression of the top-ranked miRNAs (miR-3662, miR1, miR-146a, miR-1290, and miR-29c) in sixty breast cancer patients and twenty healthy controls using quantitative real-time polymerase chain reaction. +lncRNA target 34269220 hsa-mir-29 Ischemic Stroke The inhibition of miR-29b expression decreased the neurological function score and reduced the cerebral infarction volume and cell apoptosis. +transcription factor target 34269220 hsa-mir-29b Ischemic Stroke These findings suggest that the inhibition of miR-29b inhibits oxidative stress and cell apoptosis in ischemic stroke, producing therapeutic effects in ischemic stroke. +circRNA target 34269180 hsa-mir-370 Glioblastoma In conclusion, circCLSPN elicited an oncogenic role in tumorigenesis and malignant progression of human GBM cells through circCLSPN-miR3p-USP39 pathway. +genetics_knock down_suppress 34269081 hsa-mir-204 Carcinoma, Non-Small-Cell Lung 3p inhibitor could reverse the inhibitory effect of LINC00958 knockdown on proliferation and migration of NSCLC cells. +lncRNA target 34269003 hsa-mir-335 Breast Neoplasms The Editors of JBUON issue an Expression of Concern to 'MicroRNA-335 inhibits the growth, chemo-sensitivity, and metastasis of human breast cancer cells by targeting MAP3K2', by Yajue Wang, Feng Wen; JBUON 2020;25(2):666-674; PMID: 32521851. +lncRNA target 34269002 hsa-mir-22 Glioma The Editors of JBUON issue an Expression of Concern to 'MicroRNA-22 regulates the proliferation, drug sensitivity and metastasis of human glioma cells by targeting SNAIL1', by Yunqiang Zhang, Lijun Tu, Xiuhong Zhou, Bin Li; JBUON 2020;25(1):491-496; PMID: 32277674. +lncRNA target 34268979 hsa-mir-214 Pancreatic Carcinoma CONCLUSION: In conclusion, the expression of miR-214 is highly expressed in pancreatic cancer tissues, and the down-regulation of ING4 protein expression can inhibit the proliferation, invasion and migration of pancreatic cancer cells, promote their apoptosis, and can be used as a new molecular target for the diagnosis and treatment of pancreatic cancer. +lncRNA target 34268963 hsa-mir-613 Glioma CONCLUSION: LncRNA MALAT1 can promote the proliferation and invasion of glioma cells and inhibit the apoptosis of glioma cells by sponging miR-613. +other 34268958 hsa-mir-24 Prostatic Neoplasms 3p. +genetics_overexpression_promote 34268937 hsa-mir-183 Laryngeal Neoplasms CONCLUSIONS: The overexpression of miR-183 can inhibit the drug resistance of the human primary laryngeal cancer cells to 5-Fu, promote cancer cell apoptosis and inhibit their invasive and migratory abilities at the same time, whose mechanism may be associated with the targeted regulation of the TBX3/PTEN signaling pathway by miR-183. +lncRNA target 34268933 hsa-mir-206 Mouth Neoplasms CONCLUSIONS: HOTTIP promotes the tumor proliferation activity and migration of oral cancer cells through modulating miR-206. +lncRNA target 34268922 hsa-mir-7 Ovarian Neoplasms CONCLUSIONS: CircHIPK3 has an obviously increased expression level in the carcinoma tissues of ovarian cancer patients, and the inhibition of circHIPK3 can activate the miR +genetics_overexpression_promote 34268920 hsa-mir-186 Uterine Cervical Neoplasms Overexpression of microRNA +other 34268918 hsa-mir-139 Ovarian Neoplasms 5p and FGF-2 contributes to the diagnosis and treatment of OC, and is an available biomarker for the diagnosis and prognosis of patients. +other 34268792 hsa-mir-551b Thyroid Cancer, Papillary 3p are aberrantly expressed in papillary thyroid carcinomas and correlated with clinicopathological features. +other 34268792 hsa-mir-1301 Thyroid Cancer, Papillary 3p are aberrantly expressed in papillary thyroid carcinomas and correlated with clinicopathological features. +other 34268792 hsa-mir-455 Thyroid Cancer, Papillary 3p are aberrantly expressed in papillary thyroid carcinomas and correlated with clinicopathological features. +other 34268792 hsa-mir-1296 Thyroid Cancer, Papillary 3p are aberrantly expressed in papillary thyroid carcinomas and correlated with clinicopathological features. +other 34268792 hsa-mir-532 Thyroid Cancer, Papillary 3p are aberrantly expressed in papillary thyroid carcinomas and correlated with clinicopathological features. +other 34268484 hsa-mir-21 Ischemic And Traumatic Injuries In the present review, we discuss the role of miR-21 in acute CNS injuries which is currently thought to be a potent neuroprotective microRNA. +other 34268410 hsa-let-7a Stomach Neoplasms 3p) might be potential biomarkers for the early diagnosis of GC patients, but this finding should be regarded with caution. +other 34268410 hsa-mir-135b Stomach Neoplasms 3p) might be potential biomarkers for the early diagnosis of GC patients, but this finding should be regarded with caution. +other 34268410 hsa-mir-455 Stomach Neoplasms 3p) might be potential biomarkers for the early diagnosis of GC patients, but this finding should be regarded with caution. +circRNA target 34268375 hsa-mir-1827 Glioma The downregulation of circ_0080229 inhibited gliomas in vivo and suppressed U87 and U251 cell lines in vitro, which the transfection of the miR-1827 inhibitor could reverse. +transcription factor target 34268365 hsa-mir-21 Spinal Cord Ischemia 5p, its target genes (MAP2K3 and PPP1R3B), and related signaling pathways. +other 34268360 hsa-mir-183 Colorectal Neoplasms By using cox proportional hazard models, we then developed 6-miRNA-classifier (miR-183, -20a, -21, -195, -139 and -20a) to predict prognosis in clinical cohort, that had significantly superior predictive performance compared to other clinicopathological factors, and could successfully identify high-risk stage II and III CRC patients with poor prognosis [hazard ratio (HR) =2.16; P=0.0048]. +other 34268360 hsa-mir-183 Stomach Neoplasms By using cox proportional hazard models, we then developed 6-miRNA-classifier (miR-183, -20a, -21, -195, -139 and -20a) to predict prognosis in clinical cohort, that had significantly superior predictive performance compared to other clinicopathological factors, and could successfully identify high-risk stage II and III CRC patients with poor prognosis [hazard ratio (HR) =2.16; P=0.0048]. +genetics_overexpression_promote 34268117 hsa-mir-338 Nasopharyngeal Carcinoma 5p overexpression on NPC development were reversed by upregulating WNT2B. +genetics_overexpression_promote 34267819 hsa-mir-106a spinal cord glioma In addition, overexpression of CELF-2 in spinal cord glioma cells reversed the tumor-promoting effects of miR-106a-5p both in vitro and in vivo. +target gene 34267818 hsa-mir-203 Pancreatic Neoplasms MicroRNA-203-3p inhibits the proliferation, invasion and migration of pancreatic cancer cells by downregulating fibroblast growth factor 2. +other 34267816 hsa-mir-377 Liver Neoplasms lncRNA LOXL1-AS1 promotes liver cancer cell proliferation and migration by regulating the miR-377-3p/NFIB axis. +target gene 34267814 hsa-mir-181a Stomach Neoplasms miR-181a-5p, inhibited the proliferation of drug-resistant cells and enhanced their sensitivity to DDP. +other 34267778 hsa-mir-96 Pancreatic Carcinoma Only mimi-surv found miR-96, a previously unidentified PDAC-related miRNA in these two real datasets. +other 34267554 hsa-mir-567 Squamous Cell Carcinoma of Head and Neck The lncRNA also promoted OSCC cell proliferation by directly binding to miR-567, leading to an increase in CDK8 expression. +other 34267179 hsa-mir-195 Diabetic Retinopathy However, the function and mechanism of miR-195 in EMT and cell permeability in diabetic retinopathy remain largely unclear. +lncRNA target 34267173 hsa-mir-181b Inflammation Notably, we found that neurobehavioral scores, brain water content, and neuronal apoptosis were decreased and caspase3 activity was reduced in MEG3-shRNA-treated ICH rats, while we observed the opposite result in ICH+MEG3-shRNA+miR-181b inhibitor rats. +lncRNA target 34267173 hsa-mir-181b Cerebral Hemorrhage Notably, we found that neurobehavioral scores, brain water content, and neuronal apoptosis were decreased and caspase3 activity was reduced in MEG3-shRNA-treated ICH rats, while we observed the opposite result in ICH+MEG3-shRNA+miR-181b inhibitor rats. +lncRNA target 34267173 hsa-mir-181b Brain Ischemia Notably, we found that neurobehavioral scores, brain water content, and neuronal apoptosis were decreased and caspase3 activity was reduced in MEG3-shRNA-treated ICH rats, while we observed the opposite result in ICH+MEG3-shRNA+miR-181b inhibitor rats. +circulation_biomarker_diagnosis_ns 34266857 hsa-mir-21 Adenomatous Polyposis Coli Finally, the reported data suggest miRNA-21 could serve as a predictive serum biomarker for polyposis burden in patients with FAP. +lncRNA target 34266696 hsa-mir-612 Melanoma The oncogenic role of the LINC01116/miR-3612/GDF11/SDC3 axis in melanoma was finally demonstrated. CONCLUSION: Conclusively, LINC01116 sequestered miR-3612 and targeted GDF11 and SDC3 to contribute to the progression of melanoma. +lncRNA target 34266379 hsa-mir-144 Lung Abscess This study was designed to explore the therapeutic effects of Propofol, both in vivo and in vitro, on lung I/R injury and the underlying mechanisms related to metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)/microRNA-144 (miR-144)/glycogen synthase kinase-3beta (GSK3beta). CONCLUSION: Overall, our study demonstrated that Propofol played a protective role in lung I/R injury by suppressing autophagy and decreasing release of inflammatory factors, with the possible involvement of the MALAT1/miR-144/GSK3beta axis. +lncRNA target 34266345 hsa-mir-25 Carcinoma, Non-Small-Cell Lung 3p/PTEN/PI3K/AKT axis might accelerate DDP tolerance in NSCLC, which may serve as a potential target for chemotherapy resistance in NSCLC. +genetics_overexpression_promote 34266334 hsa-mir-18a Pulmonary Disease, Chronic Obstructive Upregulation of miR-18a-5p reversed the influence of CASC2 on cell apoptosis and inflammation in 16HBE cells. Overexpression of CASC2 might inhibit the bronchial epithelial cell apoptosis and inflammation via targeting miR-18a-5p/IGF1 axis.The reviews of this paper are available via the supplemental material section. +other 34266326 hsa-mir-21 Carcinoma, Hepatocellular CONCLUSIONS: miR-21 is a valuable biomarker for the early diagnosis of HCC. +circulation_biomarker_diagnosis_up 34265390 hsa-mir-874 Ischemic Stroke 3p and IL1B levels in serum of patients with IS were measured. +other 34264867 hsa-mir-182 Obesity 5p-induced signaling pathway in adipose tissue may be an effective approach to ameliorate obesity and associated metabolic diseases. +other 34264867 hsa-mir-182 Metabolic Diseases Activation of the miR5p-induced signaling pathway in adipose tissue may be an effective approach to ameliorate obesity and associated metabolic diseases. +circulation_biomarker_prognosis_ns 34264524 hsa-mir-10b Breast Neoplasms Therefore, we aimed to investigate the circulating levels of miR-10b and its target soluble E- cadherin as potentially easily accessible biomarkers for breast cancer. CONCLUSION: Our data suggest that circulating miR-10b could be utilized as a potential non-invasive serum biomarker for diagnosis and prognosis of breast cancer with better performance to predict BC metastasis achieved on measuring it simultaneously with serum sE-cadherin. +lncRNA target 34264003 hsa-mir-103a Adenocarcinoma of Lung CONCLUSIONS: SVIL-AS1 inhibited chemoresistance by acting as a sponge for miR-103a and upregulating ICE1 expression, which may be a potential therapeutic target for chemotherapy in LUAD. +transcription factor target 34263708 hsa-mir-15b COVID-19 Our findings provide evidence that hsa-miR15b-5p may suppresses viral infection and proliferation by targeting the RNA template component of SARS-CoV-2 RdRp. +other 34263426 hsa-mir-128 Glioma 3p/ITGA5 axis was involved in glioma initiation and progression, and might offer a potential novel strategy for treatment of glioma. +exosome 34262466 hsa-mir-99a Tuberous Sclerosis Thus, EV-derived miR3p and mIR-99a-5p axes may represent therapeutic targets or biomarkers for TSC disease. +exosome 34262466 hsa-mir-212 Tuberous Sclerosis Thus, EV-derived miR3p and mIR-99a-5p axes may represent therapeutic targets or biomarkers for TSC disease. +exosome 34262466 hsa-mir-212a Tuberous Sclerosis Thus, EV-derived miR3p and mIR-99a-5p axes may represent therapeutic targets or biomarkers for TSC disease. +other 34262342 hsa-mir-758 Uterine Cervical Neoplasms Circular RNA Circ_0003221 Promotes Cervical Cancer Progression by Regulating miR-758-3p/CPEB4 Axis. +other 34262334 hsa-mir-576 Ischemic Stroke In addition, we identified miR3p as having the most regulatory roles in both T2DM and ischemic stroke. +other 34262334 hsa-mir-576 Diabetes Mellitus In addition, we identified miR3p as having the most regulatory roles in both T2DM and ischemic stroke. +other 34262312 hsa-mir-574 Diabetic Nephropathies 5p. +exosome 34261453 hsa-mir-34c Cholangiocarcinoma BACKGROUND: This study aimed to investigate the exact regulatory mechanisms of exosomal miR-34c in mediating communication between cholangiocarcinoma cells and fibroblasts. Additionally, cancer-associated fibroblasts (CAFs) activated by downregulation of exosomal miR-34c promoted cholangiocarcinoma progression. +transcription factor target 34260911 hsa-mir-29c Leukemia A negative correlation of miR-29c and RAG1 levels is also observed in leukemia patients, suggesting the potential use of miR-29c as a biomarker and a therapeutic target. +other 34260396 hsa-let-7b Inflammation aeruginosa lung infections are associated with a hyperinflammatory state, treatment with let-7b-5p and a beta-lactam antibiotic in nanoparticles or EVs may benefit patients with antibiotic-resistant P. +other 34260071 hsa-mir-4301 Rotavirus Infections To investigate the role of miR-4301 in rotavirus (RV)-infected Caco-2 cells. +lncRNA target 34259681 hsa-mir-138 Triple Negative Breast Neoplasms Moreover, on elucidating the molecular mechanism, we found that CDHP-4@PP-NPs could exhibit apoptotic, anti-migratory, as well as anti-stemness activity against TNBC cell lines through the downregulation of miR-138. Our recent study, hence for the first time, unravels the synthesis of CDHP-4@PP-NPs and the molecular mechanism behind the anti-migration, anti-stemness and anti-tumor efficacy of the nanoparticles against the TNBC cells through the miR-138/p65/TUSC2 axis. +lncRNA target 34259142 hsa-mir-200c Pancreatic Carcinoma Further experiments revealed that down-regulation of miR-200c-3p expression reversed the inhibitory effect of lowly expressed circPUM1 on PC cells. +circulation_biomarker_diagnosis_ns 34259105 hsa-mir-6515 Thromboangiitis Obliterans 5p.Conclusions: Our findings imply that circulating exosomal miR +circulation_biomarker_prognosis_ns 34258959 hsa-mir-21 Lymphoma, Large B-Cell, Diffuse CONCLUSIONS: The study suggested that plasma miR-21 might be a valuable non-invasive prognostic marker of response to treatment in DLBCL patients. +genetics_knock down_promote 34258391 hsa-mir-145 Urinary Bladder Neoplasms Circular RNA VANGL1 knockdown suppressed viability, promoted apoptosis, and increased doxorubicin sensitivity through targeting miR-145-5p to regulate SOX4 in bladder cancer cells. +genetics_knock down_suppress 34258298 hsa-mir-382 Uterine Cervical Neoplasms 5p knockdown on cervical cancer cells. +lncRNA target 34258297 hsa-mir-497 Endometrial Neoplasms CONCLUSION: This study illustrates that circSLC6A6 plays a role in promoting EC progression via the miR5p-mediated PI4KB/hedgehog pathway. +circRNA target 34258296 hsa-mir-136 Lung Neoplasms Mechanistically, in lung cancer and using bioinformatics, we demonstrated that circ_0044516 sponges miR-136 targeting MAT2A. +other 34258170 hsa-mir-1269a Carcinoma, Hepatocellular Two novel regulatory pathways, EGOT-miR5p-XYLT2 axis and SERHL-miR-1269a/miR-193b-3p-BCL2L1/SYK/ARNT/CHST3/ axis, were built up and contribute to the underlying mechanism of HCC pathogenesis. +other 34258170 hsa-mir-193b Carcinoma, Hepatocellular Two novel regulatory pathways, EGOT-miR5p-XYLT2 axis and SERHL-miR-1269a/miR-193b-3p-BCL2L1/SYK/ARNT/CHST3/ axis, were built up and contribute to the underlying mechanism of HCC pathogenesis. +target gene 34258104 hsa-mir-140 Neuroblastoma Concurrent targeting of MAP3K3 and BRD4 by miR-3140-3p overcomes acquired resistance to BET inhibitors in neuroblastoma cells. +lncRNA target 34257820 hsa-mir-199b Diabetic Nephropathies These results demonstrate that hsa-miR-199b-3p improves E-cadherin expression and prevents the progression of DN through targeting KDM6A. miR-199b-3p could be a future biomarker or target for the diagnosis or treatment of DN. +target gene 34257725 hsa-mir-148a Uterine Cervical Neoplasms MicroRNA-148a-3p inhibits the proliferation of cervical cancer cells by regulating the expression levels of DNMT1 and UTF1. +circulation_biomarker_diagnosis_up 34257722 hsa-mir-10b Adenocarcinoma of Lung In conclusion, EV-associated miR-10b may be a potential diagnostic biomarker for LUAD that is superior to plasma miR-10b and TMs. +genetics_overexpression_promote 34257708 hsa-mir-221 Myocardial Reperfusion Injury 5p showed an opposite trend to that of ADAM8 overexpression. +lncRNA target 34257707 hsa-mir-2355 Triple Negative Breast Neoplasms In addition, chromobox 5 (CBX5) was identified to be targeted by miR +lncRNA target 34257670 hsa-mir-375 Oral Submucous Fibrosis Functional rescue experiments were further performed to verify the role of the miR-375/FOXF1 axis in OSF. We highlighted that ADSC-EVs inhibited fBMF fibrosis and then suppressed OSF progression via the miR-375/FOXF1 axis. +target gene 34257656 hsa-mir-326 Stomach Neoplasms LncRNA SNHG3 Promotes Gastric Cancer Cells Proliferation, Migration, and Invasion by Targeting miR-326. +genetics_overexpression_suppress 34257650 hsa-mir-466 Carcinoma, Hepatocellular The results showed that miR-466 was significantly downregulated in HCC tissues and cell lines, and inhibited proliferation, invasion, and high apoptosis were found in HCC cells when miR-466 was overexpressed. +other 34257616 hsa-mir-543 Pars Planitis MicroRNAs (miRNAs) are reported to be master regulators in a variety of diseases, including IUA, but the role of microRNA-543 (miR-543) in IUA remains to be elucidated. +genetics_knock down_promote 34257576 hsa-mir-491 Lung Neoplasms 5p restored the MALAT1 knockdown-induced inhibition of the progression of lung carcinoma. +circRNA target 34257535 hsa-mir-1243 Squamous Cell Carcinoma of Head and Neck Collectively, the current study demonstrated that circ_0043265 was downmodulated in TSCC and was identified as a ceRNA that restrained the cell proliferation, migration and invasion of SCC25 and Cal27 cells via modulating the miR-1243/SALL1 axis. +genetics_overexpression_suppress 34257520 hsa-mir-450a-2 Cardiomyopathies 3p overexpression and improves cardiac fibrosis in patients with atrial fibrillation. +genetics_overexpression_suppress 34257520 hsa-mir-450a-2 Atrial Fibrillation 3p overexpression and improves cardiac fibrosis in patients with atrial fibrillation. +exosome 34257272 hsa-mir-92a Retinoblastoma Specifically, our data showed that miR-92a-3p was enriched in RB exosomes. Thus, our work suggests that exosomal miR-92a-3p is involved in tumor angiogenesis and might be a promising therapeutic candidate for retinoblastoma. +circRNA target 34257163 hsa-mir-365a Neurodegenerative Diseases Collectively, our results show that the circRNA FUT10/miR365a-3p/HOXA9 axis is a promising therapeutic target and are expected to facilitate the development of therapeutic strategies to improve the prognosis of degenerative muscle disease. +lncRNA target 34257080 hsa-mir-24 Gerodermia osteodysplastica 5p expression via c-Myc, an oncogenic transcription factor in cancer cells. +genetics_GWAS 34257080 hsa-mir-24 Adenocarcinoma of Lung Finally, we provide evidence that TP53 mutations coupled with high miR5p expression predict poor prognosis in patients with lung adenocarcinoma. +genetics_GWAS 34257080 hsa-mir-24 Carcinoma, Non-Small-Cell Lung We report that miR5p is upregulated in human cancer cell lines and non-small cell lung carcinoma (NSCLC) tumors carrying TP53 GOF mutations. +exosome 34256859 hsa-mir-100 Hypocalciuric hypercalcemia, familial, type 1 5p expression rescued the reduction in osteogenesis and angiogenesis caused by the NONFH exosomes by activating the BMPR2/SMAD1/5/9 signalling pathway. +exosome 34256859 hsa-mir-100 Femur Head Necrosis CONCLUSION: The NONFH exosomal miR5p can lead to NONFH-like damage by targeting BMPR2 and suppressing the BMPR2/SMAD1/5/9 signalling pathway, which may be involved in the pathophysiological mechanisms of nontraumatic osteonecrosis of the femoral head (NONFH). +other 34256840 hsa-mir-126 COVID-19 3p and DICER1 in COVID-19 patients with any grade (P < 0.05) and during hospitalization. +other 34256840 hsa-mir-17 COVID-19 3p and DICER1 in COVID-19 patients with any grade (P < 0.05) and during hospitalization. +other 34256840 hsa-mir-29a COVID-19 3p and DICER1 in COVID-19 patients with any grade (P < 0.05) and during hospitalization. +other 34256840 hsa-mir-1 COVID-19 3p and DICER1 in COVID-19 patients with any grade (P < 0.05) and during hospitalization. +other 34256802 hsa-mir-126 Cardiomegaly CONCLUSIONS: AA supplementation upregulated the expression of miR-126 and conferred cardio-protection effect against AngII induced cardiac hypertrophy. +other 34256802 hsa-mir-126 Diabetic Nephropathies CONCLUSIONS: AA supplementation upregulated the expression of miR-126 and conferred cardio-protection effect against AngII induced cardiac hypertrophy. +genetics_overexpression_promote 34256796 hsa-mir-126 Carcinoma, Endometrioid Moreover, overexpression of MCM3AP-AS1 and VEGF increased the migration and invasion rates of EC cells, while overexpression of miR-126 suppressed these cell behaviors. +genetics_overexpression_promote 34256371 hsa-mir-192 Alzheimer Disease Overexpression of miR +genetics_overexpression_promote 34256086 hsa-mir-135a Meningitis, Bacterial METHODS: In vitro BBB models were developed by co-culturing hCMEC/D3 cells with glioma cells, whereupon the glioma-exposed endothelial cells (GECs) were treated with a series of mimics, inhibitors, overexpression plasmids, and shRNAs for evaluating whether NEAT1, microRNA-135a (miR-135a) and hypoxia-inducible factor 1alpha (HIF1alpha) mediated BBB integrity and permeability. +other 34255836 hsa-mir-135b Pancreatic Carcinoma Our results support the identification of miR135b from the original study as a potential biomarker of PDAC and identify other potentially stronger miRNA biomarkers of PDAC. +lncRNA target 34255617 hsa-mir-613 Nasopharyngeal Carcinoma Taken all together, these findings highlight FAM225B as an oncogene that promotes NPC proliferation and metastasis through miR-613/CCND2 axis. +other 34255383 hsa-mir-10b Infertility 5p)-mRNAs interaction network. +other 34255383 hsa-mir-99a Infertility 5p)-mRNAs interaction network. +other 34255383 hsa-mir-26a Infertility 5p)-mRNAs interaction network. +other 34255383 hsa-mir-151 Infertility 5p)-mRNAs interaction network. +other 34255190 hsa-mir-485 Cicatrix, Hypertrophic 5p and thereby activates TGF-beta1/Smad signaling pathway, promoting the abnormal proliferation of fibroblasts and excessive deposition of ECM in hypertrophic scar formation. +other 34254987 hsa-mir-146a Glaucoma TRANSITIONAL RELEVANCE: The IOP-lowering effects of miR-146 observed in rats provides a necessary step toward the development of an effective gene therapy for glaucoma in humans. +other 34254987 hsa-mir-146 Glaucoma TRANSITIONAL RELEVANCE: The IOP-lowering effects of miR-146 observed in rats provides a necessary step toward the development of an effective gene therapy for glaucoma in humans. +genetics_knock down_promote 34254950 hsa-mir-877 Esophageal Squamous Cell Carcinoma In conclusion, our results indicated the oncogenic role of linc00941 in ESCC, and knockdown of linc00941 suppressed ESCC cell proliferation, invasion, migration and EMT via interacting with miR +lncRNA target 34254931 hsa-mir-197 Carcinoma, Non-Small-Cell Lung Survival analysis data showed that the low expression of hsa_circ_0026337 was significantly associated with shortened survival time in NSCLC (P = 0.037), which increased the expression level of hsa-miR3p, thereby inhibiting the translation of specific proteins. +other 34254931 hsa-mir-1252 Carcinoma, Non-Small-Cell Lung 3p and miR-558, respectively. +other 34254931 hsa-mir-494 Carcinoma, Non-Small-Cell Lung 3p and miR-558, respectively. +other 34254931 hsa-mir-558 Carcinoma, Non-Small-Cell Lung 3p and miR-558, respectively. +lncRNA target 34254728 hsa-mir-3529 Adenocarcinoma of Lung Overall, FOXA1-induced LINC01287 serves as a competing endogenous RNA to promote proliferation and inhibit apoptosis of LUAD cells via upregulation of RNASEH2A expression at the posttranscriptional level by competitively combining with miR +transcription factor target 34254638 hsa-mir-100 Atherosclerosis This study demonstrates that hUCMSC-Ex-miR5p inhibits cell progression and inflammatory response in eosinophils via the FZD5/Wnt/beta-catenin pathway, thereby alleviating atherosclerosis progression. +lncRNA target 34254453 hsa-mir-21 Lung Neoplasms 5p mimic damaged the inhibitory effect of SMAD7. +circulation_biomarker_diagnosis_ns 34254354 hsa-mir-221 Arthritis, Rheumatoid 3p can colocate in the nucleus and cytoplasm in RA-FLSs. +lncRNA target 34254279 hsa-mir-218 cervical squamous cell carcinoma Circ-ATAD1 is upregulated in CSCC and may regulate cell proliferation and apoptosis by suppressing the maturation of miR-218. +genetics_knock down_suppress 34253241 hsa-mir-599 Colorectal Neoplasms ONECUT2 overexpression recovered the effects of miR-599 on CRC malignant behaviors. +transcription factor target 34253194 hsa-mir-186 Uterine Cervical Neoplasms IGF1 could restore the inhibitory effects of miR +lncRNA target 34253104 hsa-mir-5006 Adenocarcinoma of Lung 5p/FZD1 axis might serve as a potential biomarker and therapeutic target for LUAD treatment. +lncRNA target 34252882 hsa-mir-20a Glioma We constructed a circCCDC66 regulating miRNA network and revealed miR-320a was a potential target of circCCDC66, which was down-regulated in high-grade gliomas compared to low-grade gliomas. CONCLUSIONS: CircCCDC66 could facilitate glioma cells proliferation, invasion and migration by down-regulating miR-320a and up-regulating FOXM1. +other 34252537 hsa-mir-15a Intervertebral Disc Degeneration This study aimed to understand the interactions and impact of miR-15a and NP-MSCs on chondrogenic differentiation and IVD degeneration. +other 34252537 hsa-mir-15a Substance Abuse, Intravenous This study aimed to understand the interactions and impact of miR-15a and NP-MSCs on chondrogenic differentiation and IVD degeneration. +lncRNA target 34252535 hsa-mir-92a Podocyte Hypertrophy Exogenous IL-6 stimulation up-regulated IL-6/STAT3 signaling and miR-92a-3p, reduced P57 expression and promoted podocyte proliferation, apoptosis and hypertrophy in vitro. Taken together, these results suggested that high fructose possibly increased KHK-A expression to down-regulate TTP, subsequently activated IL-6/STAT3 signaling to interfere with podocyte proliferation and apoptosis by up-regulating miR-92a-3p to suppress P57 expression, causing podocyte hypertrophy. +exosome 34252490 hsa-mir-150 Enterovirus A Infection To excavate the key circRNAs in EV-A71 infection, we comprehensively evaluated and integrated the relationship of circRNA/miRNA/mRNA, and eventually screened 2 key circRNA regulatory axes, namely hsa_circ_0017115/hsa-miR +lncRNA target 34251977 hsa-mir-762 Acute Lung Injury CONCLUSION: miR-762 is implicated in the pathogenesis of LPS-induced ALI via modulating inflammation and oxidative stress, which depends on its regulation of SIRT7 expression. +transcription factor target 34251959 hsa-mir-532 Brain Ischemia LOC366613 participates in cerebral I/R injury by regulating the miR5p/PTEN axis, potentially providing a new CI treatment target. +genetics_knock down_promote 34251586 hsa-mir-296 Atherosclerosis CONCLUSION: Taken together, circRNA_102541 was upregulated in atherosclerosis, and knockdown of circRNA_102541 suppressed cell proliferation while promoted apoptosis of HUVEC cells via miR +other 34250246 hsa-mir-137 Ovarian Neoplasms HULC was significantly upregulated and miR-137 was downregulated in PTX-resistant OC tissues and cells. Collectively, HULC modulated ITGB8 expression to promote PTX resistance of OC by sponging miR-137. +other 34250088 hsa-mir-140 Ovarian Neoplasms 5p to activate the PI3K/AKT signaling pathway and promote the proliferation, invasion, migration and EMT of OC. +circRNA target 34250012 hsa-mir-106a Sepsis Therefore, we concluded that circTLK1 contributed to sepsis-associated AKI by regulating inflammation and oxidative stress through the miR-106a-5p/HMGB1 axis. CircTLK1 and miR-106a-5p may be employed as the potential targets for the treatment of AKI. +exosome 34249964 hsa-mir-181a Colitis This indicated that MSC exosomal miR-181a may exhibit potential as a disease-modifying drug for UC. +exosome 34249964 hsa-mir-181 Colitis This indicated that MSC exosomal miR-181a may exhibit potential as a disease-modifying drug for UC. +exosome 34249903 hsa-mir-892b Breast Neoplasms Extracellular Vesicles Carry lncRNA SNHG16 to Promote Metastasis of Breast Cancer Cells via the miR-892b/PPAPDC1A Axis. +lncRNA target 34249735 hsa-mir-204 Urinary Bladder Neoplasms We also found that NRP1 was a predicted target of miR-204, miR-143, miR-145, and miR-195 in BC development. +lncRNA target 34249735 hsa-mir-143 Urinary Bladder Neoplasms We also found that NRP1 was a predicted target of miR-204, miR-143, miR-145, and miR-195 in BC development. +genetics_overexpression_promote 34249713 hsa-mir-183 Colonic Neoplasms Overexpressing THEM4 abated miR +lncRNA target 34249610 hsa-mir-133a Intervertebral Disc Degeneration The inhibition of miR-133a-5p ameliorated the acceleration of IVDD induced by the silence of FBXO6 in vitro. +target gene 34249593 hsa-mir-199 Lung Neoplasms MicroRNA-199-3p targets Sp1 transcription factor to regulate proliferation and epithelial to mesenchymal transition of human lung cancer cells. +exosome 34249474 hsa-mir-1983 Glioma Herein, we demonstrate the existence of an innate anti-glioma NK-mediated circuit initiated by glioma-released miR-1983 within exosomes, and which is under the regulation of galectin-1 (Gal-1). +lncRNA target 34249465 hsa-mir-195 Breast Neoplasms MiR-195 is a tumor suppressive microRNA in breast cancer. +other 34249465 hsa-mir-19 Breast Neoplasms Low miR-195 expressing tumors were associated with enhanced glycolysis and poor survival in ER-positive tumors, but not other subtypes of breast cancer. In conclusion, low expression of miR-195 in ER-positive breast cancer was associated with enhanced cancer cell proliferation, glycolysis, and worse overall survival. +transcription factor target 34249436 hsa-mir-23a Esophageal Squamous Cell Carcinoma Our findings describe a role for HP1BP3 in promoting tumor growth and metastasis by upregulating miR-23a to target TRAF5 in esophageal cancer. +other 34249429 hsa-mir-19b Prostatic Neoplasms MiR-19b-3p and miR-101-3p as potential biomarkers for prostate cancer diagnosis and prognosis. +other 34249429 hsa-mir-101 Prostatic Neoplasms MiR-19b-3p and miR-101-3p as potential biomarkers for prostate cancer diagnosis and prognosis. +transcription factor target 34249133 hsa-mir-20a Parkinson Disease These findings demonstrate that miR-20a-5p contributes to MPP(+)-induced mitochondrial disruption and cell damage, and miR-20a-5p might be a novel therapeutic target for PD. +other 34249125 hsa-mir-373 Thyroid Cancer, Papillary In conclusion, CREB3 activated lncRNA ZFAS1 at the transcriptional level to promote PTC metastasis by modulating miR3p/MMP3. +circRNA target 34249089 hsa-mir-590 Myocardial Infarction Circ_0124644 silencing could alleviate hypoxia-induced cardiomyocytes injury by regulating the miR3p/SOX4 axis, suggesting that it might be a target for alleviating AMI. +other 34249085 hsa-mir-361 Rectal Neoplasms In conclusion, lncRNA SNHG17 functions as an oncogenic lncRNA in rectal cancer by regulating the miR3p/STC2 axis. +lncRNA target 34249000 hsa-mir-139 Acquired Immunodeficiency Syndrome 5p inhibitor-transfected pEVs from HIV ART-naive and on-ART patients expressed reduced levels of miR +lncRNA target 34248630 hsa-mir-27a Cardiomegaly Taken together, our results revealed miR-27a-3p/Hoxa10/Kv4.3 axis as a new mechanism of Ang II-induced cardiomyocyte hypertrophy, which provided a new target for clinical prevention and treatment of cardiac hypertrophy and heart failure. +other 34248121 hsa-mir-185 ST Elevation Myocardial Infarction Conclusion Our results showed that elevated miR-185 levels at the late stage of STEMI were related to a large amount of myocardial injury and adverse remodeling. +other 34248121 hsa-mir-185 Myocardial Infarction Conclusion Our results showed that elevated miR-185 levels at the late stage of STEMI were related to a large amount of myocardial injury and adverse remodeling. +other 34247992 hsa-mir-153 Diabetic Nephropathies 3p was lower in diabetic nephropathy patients, while the expression of PAQR3 was concomitantly higher. +genetics_knock down_promote 34247598 hsa-mir-526b Melanoma Further, the inhibitory effects of NCK1-AS1 knockdown on cell proliferation and migration in melanoma were reversed by the depletion of miR-526b-5p and further counteracted by ADAM15 knockdown. +circulation_biomarker_diagnosis_up 34247489 hsa-mir-135a peripartum cardiomyopathy 3p, miR-23a-3p, and miR19b-3p) that target tyrosine kinase receptor ERBB4 and are over 4-fold upregulated in plasma of PPCM patients at the time of diagnosis. +circulation_biomarker_diagnosis_up 34247489 hsa-mir-222 peripartum cardiomyopathy 3p, miR-23a-3p, and miR19b-3p) that target tyrosine kinase receptor ERBB4 and are over 4-fold upregulated in plasma of PPCM patients at the time of diagnosis. +circulation_biomarker_diagnosis_up 34247489 hsa-mir-23a peripartum cardiomyopathy 3p, miR-23a-3p, and miR19b-3p) that target tyrosine kinase receptor ERBB4 and are over 4-fold upregulated in plasma of PPCM patients at the time of diagnosis. +circulation_biomarker_diagnosis_up 34247489 hsa-mir-130a peripartum cardiomyopathy 3p, miR-23a-3p, and miR19b-3p) that target tyrosine kinase receptor ERBB4 and are over 4-fold upregulated in plasma of PPCM patients at the time of diagnosis. +circulation_biomarker_diagnosis_up 34247489 hsa-mir-145a peripartum cardiomyopathy 3p, miR-23a-3p, and miR19b-3p) that target tyrosine kinase receptor ERBB4 and are over 4-fold upregulated in plasma of PPCM patients at the time of diagnosis. +circulation_biomarker_diagnosis_up 34247489 hsa-mir-221 peripartum cardiomyopathy 3p, miR-23a-3p, and miR19b-3p) that target tyrosine kinase receptor ERBB4 and are over 4-fold upregulated in plasma of PPCM patients at the time of diagnosis. +circulation_biomarker_diagnosis_up 34247489 hsa-mir-199a peripartum cardiomyopathy 3p, miR-23a-3p, and miR19b-3p) that target tyrosine kinase receptor ERBB4 and are over 4-fold upregulated in plasma of PPCM patients at the time of diagnosis. +circulation_biomarker_prognosis_up 34247370 hsa-mir-106a Carcinoma, Renal Cell High serum expression of miR-106a is an independent predictor for tumor TNM stage and lymph node metastasis, as well as an independent predictor for poor prognosis of RCC patients. +transcription factor target 34247369 hsa-mir-548m Orofacial Cleft Inhibiting of the expression of the MIR548M gene in oral epithelial celllines has resulted in up-regulation of the expression of SUMO1 gene which was known to involve in the pathogenesis of orofacial cleft. CONCLUSION: Dosage insufficiency of the MIR548M gene may underlie the etiology of orofacial cleft in this fetus. +transcription factor target 34247316 hsa-mir-431 Stomach Neoplasms The HIF-1alpha/HYPAL/miR5p/CDK14 (Cyclin-dependent kinase 14) axis activated the Wnt/beta-catenin signaling pathway and induced GC cell proliferation while inhibiting apoptosis. +circulation_biomarker_diagnosis_up 34247256 hsa-mir-548a Graft vs Host Disease The expressions of plasma miR +circulation_biomarker_diagnosis_up 34247256 hsa-mir-5787 Graft vs Host Disease The expressions of plasma miR +circulation_biomarker_diagnosis_up 34247256 hsa-mir-455 Graft vs Host Disease The expressions of plasma miR +genetics_overexpression_promote 34246986 hsa-mir-138 Melanoma Our data shows that the overexpression of miR +other 34246852 hsa-mir-340 Glioma METHODS AND MATERIALS: RT-qPCR was performed to evaluate the expression levels of LINC00662, miR5p in glioma tissues and cell lines. +lncRNA target 34246727 hsa-let-7e Polycystic Ovary Syndrome Let-7e may thus be a potential therapeutic target in non-HA PCOS. +lncRNA target 34246626 hsa-mir-19a Sepsis In conclusion, miR-19a-3p may suppress DIC by targeting TF and might be a potential therapeutic target in treating sepsis-induced DIC. +lncRNA target 34246626 hsa-mir-19a Disseminated Intravascular Coagulation In conclusion, miR-19a-3p may suppress DIC by targeting TF and might be a potential therapeutic target in treating sepsis-induced DIC. +circulation_biomarker_diagnosis_up 34246297 hsa-mir-142 Gout 3p were significantly upregulated (p < 0.001) in the plasma of hyperuricemia and gout patients compared to normouricemic individuals. +circulation_biomarker_diagnosis_up 34246297 hsa-mir-17 Gout 3p were significantly upregulated (p < 0.001) in the plasma of hyperuricemia and gout patients compared to normouricemic individuals. +circulation_biomarker_diagnosis_up 34246297 hsa-mir-18a Gout 3p were significantly upregulated (p < 0.001) in the plasma of hyperuricemia and gout patients compared to normouricemic individuals. +circulation_biomarker_diagnosis_up 34246297 hsa-mir-223 Gout 3p were significantly upregulated (p < 0.001) in the plasma of hyperuricemia and gout patients compared to normouricemic individuals. +genetics_knock down_suppress 34245111 hsa-mir-621 Stomach Neoplasms Dual-luciferase reporter gene assay showed that miR-621 could bind circ_0000064 and SYF2 3'UTR; in addition, miR-621 overexpression or SYF2 knockdown could partially weaken the cancer-promoting effect of circ_0000064 on GC cells. +exosome 34244990 hsa-mir-627 Carcinoma, Non-Small-Cell Lung 3p/Smads signaling pathway by transferring exosomes to THP-1 cells. +genetics_overexpression_promote 34244973 hsa-mir-202 Uterine Cervical Neoplasms In conclusion, the overexpression of miR +other 34244572 hsa-mir-378a psoriasis 1 Here, we reported a significant up-regulation of miR-378a-3p (miR-378a) in skin biopsies from active psoriatic lesions while it was down-regulated after treatment with methotrexate or narrow-band ultraviolet B phototherapy. These findings offer a mechanistic model where miR-378a contributes to the pathogenesis of psoriasis. +lncRNA target 34244473 hsa-mir-214 Carcinoma, Renal Cell 5p/E2F2 axis, and lncRNA RCAT1 might be a novel prognostic biomarker and a potential therapeutic target for renal cell carcinoma. +other 34244338 hsa-mir-378f Ischemic Stroke Validation using qRT-PCR showed that miR-378f and miR-450b-5p were significantly elevated among the cardioembolic thrombi; both microRNAs were inversely correlated with the ejection fraction from echocardiography. +other 34244338 hsa-mir-93 Ischemic Stroke 5p than those from neurologically stable patients. +other 34244338 hsa-mir-629 Ischemic Stroke 5p than those from neurologically stable patients. +other 34244338 hsa-mir-450b Ischemic Stroke Validation using qRT-PCR showed that miR-378f and miR-450b-5p were significantly elevated among the cardioembolic thrombi; both microRNAs were inversely correlated with the ejection fraction from echocardiography. +other 34243729 hsa-mir-200c Pulmonary Disease, Chronic Obstructive MiR-200c-3p expression was significantly decreased in lung tissues from COPD patients compared to that in healthy controls. +circulation_biomarker_diagnosis_ns 34243103 hsa-mir-146a Multiple Sclerosis, Relapsing-Remitting RESULTS: Plasma levels of miR-34a (p<0.001) and miR-125a-5p (p=0.034) were higher, whereas miR-146a-5p levels were lower (p=0.041) in RRMS patients compared to CTRs. +circulation_biomarker_diagnosis_ns 34243103 hsa-mir-125a Multiple Sclerosis, Relapsing-Remitting RESULTS: Plasma levels of miR-34a (p<0.001) and miR-125a-5p (p=0.034) were higher, whereas miR-146a-5p levels were lower (p=0.041) in RRMS patients compared to CTRs. +other 34243103 hsa-mir-34a Multiple Sclerosis, Relapsing-Remitting The aim of this study was to evaluate the expression of selected inflamma-miRs, i.e., miR-34a-5p, -125a-5p, -146a-5p, and -155, in relapsing-remitting multiple sclerosis (RRMS) and their modulation after treatment with dimethyl fumarate (DMF). +circulation_biomarker_diagnosis_ns 34242639 hsa-mir-126 Renal Insufficiency, Chronic CONCLUSIONS: We found baseline serum miR-126 levels were associated with changes in eGFR and new CKD cases in a five-year prospective study. +lncRNA target 34241734 hsa-mir-172b Dehydration This study focused on eight miRNAs (Novel_8, Novel_9, Novel_105, miR156d-3p, miR160a-5p, miR162a-3p, miR172b-3p and miR398a-5p) and their putative targets where results indicate that they may play a vital role at different post-transcriptional levels against drought and heat stresses. +lncRNA target 34241734 hsa-mir-398a Dehydration This study focused on eight miRNAs (Novel_8, Novel_9, Novel_105, miR156d-3p, miR160a-5p, miR162a-3p, miR172b-3p and miR398a-5p) and their putative targets where results indicate that they may play a vital role at different post-transcriptional levels against drought and heat stresses. +lncRNA target 34241734 hsa-mir-156d Dehydration This study focused on eight miRNAs (Novel_8, Novel_9, Novel_105, miR156d-3p, miR160a-5p, miR162a-3p, miR172b-3p and miR398a-5p) and their putative targets where results indicate that they may play a vital role at different post-transcriptional levels against drought and heat stresses. +other 34241580 hsa-mir-381 Melanoma Importantly, we further confirmed that ZBED3-AS1 promoted the malignant progression of melanoma by regulating miR3p/ARID4B axis to activate the phosphatidylinositol 3-kinase/AKT serine/threonine kinase (PI3K/AKT) signalling pathway. +genetics_knock down_suppress 34240756 hsa-mir-204 Acute Kidney Injury After transfection, CCK-8, flow cytometry, and TUNEL staining assays were performed to evaluate the effects of MALAT1 and miR-204 on AKI progression. CONCLUSIONS: Collectively, these results illustrated that knockdown of lncRNA MALAT1 could ameliorate AKI progression and inflammation by targeting miR-204 through APOL1/NF-kappaB signaling. +transcription factor target 34240406 hsa-mir-335 Melanoma 5p expression with consequent downregulation of GJB5, one of its targets. +transcription factor target 34240323 hsa-mir-206 Cholangiocarcinoma CONCLUSION: Altogether, our findings clarified that miR-206 inhibited CCA malignancy by negatively regulating JARID2. +other 34240204 hsa-mir-509 Uterine Cervical Neoplasms CONCLUSIONS: HOXA-AS2 accelerates cellular progression in cervical cancer by the miR3p/BTN3A1 axis. +lncRNA target 34240166 hsa-mir-6875 Abortion, Habitual 5p is involved in RSA by decreasing the differentiation of pDCs via inhibition of the STAT3/E2-2 signaling pathway. +lncRNA target 34240140 hsa-mir-222 Adenocarcinoma of Lung Importantly, miR-222 expression decreased cell viability, phenocopying the tumor suppressor role of SMARCA4-SWI/SNF complexes in LUAD. +genetics_overexpression_suppress 34239888 hsa-mir-199a Cholangiocarcinoma Functionally, the silence of SNHG12 inhibited the proliferation and metastasis of ICC cells, while miR-199a-5p overexpression exhibited an opposite result. +lncRNA target 34239873 hsa-mir-194 Carcinoma, Hepatocellular CONCLUSION: CircUBAP2 plays a significant role in promoting HCC via the miR +genetics_overexpression_promote 34239673 hsa-mir-27a Endometrial Neoplasms USP46 expression was downregulated in EC cell lines during miR-27a overexpression. +genetics_overexpression_promote 34239606 hsa-mir-522 Myocardial Infarction TNRC6A regulates cell viability and apoptosis of cardiomyocytes after MI, and TNRC6A-induced MI can be reversed by overexpression of miR +exosome 34239562 hsa-mir-22 Colorectal Neoplasms Exosomes miR-22-3p Derived from Mesenchymal Stem Cells Suppress Colorectal Cancer Cell Proliferation and Invasion by Regulating RAP2B and PI3K/AKT Pathway. +lncRNA target 34239561 hsa-mir-215 Breast Neoplasms Moreover, miRNAs selection tools predicted that miR-215 and mir5p which have a tumor suppressor role in BC can be targeted by our candidate circRNAs to affect the PI3K/AKT pathway; in conclusion, further studies are required to validate the oncogene role of our candidate circRNAs through the PI3k pathway. +lncRNA target 34239561 hsa-mir-383 Breast Neoplasms Moreover, miRNAs selection tools predicted that miR-215 and mir5p which have a tumor suppressor role in BC can be targeted by our candidate circRNAs to affect the PI3K/AKT pathway; in conclusion, further studies are required to validate the oncogene role of our candidate circRNAs through the PI3k pathway. +other 34239351 hsa-mir-2355 Carcinoma, Hepatocellular Finally, a candidate regulatory microRNA, miR5p, for PYCR1 mRNA was discovered in HCC. +genetics_knock down_suppress 34239305 hsa-mir-140 Breast Neoplasms Knockdown of LINC00504 Inhibits the Proliferation and Invasion of Breast Cancer via the Downregulation of miR-140-5p. +transcription factor target 34239303 hsa-mir-567 Alzheimer Disease In the current study, the improvement effects of rTMS on MCI associated with AD were explored by focusing on miR-567/NEUROD2/PSD95 axis. CONCLUSION: The findings outlined in the current study demonstrated that rTMS treatment could protect brain against AD-induced MCI without significant side effects, and the function depended on the inhibition of miR-567. +lncRNA target 34239033 hsa-mir-27a Sepsis Altogether, our study revealed that NEAT1 plays a promoting role in the progression of ARDS via the NEAT1/miR-27a/PTEN regulatory network, providing new insight into the pathologic mechanism behind ARDS. +lncRNA target 34239033 hsa-mir-27a Lung Injury Altogether, our study revealed that NEAT1 plays a promoting role in the progression of ARDS via the NEAT1/miR-27a/PTEN regulatory network, providing new insight into the pathologic mechanism behind ARDS. +other 34239017 hsa-mir-29a Stomach Neoplasms Additionally, low expression of miR-29a was an independent prognostic biomarker of OS and DSS in gastric cancer patients. +exosome 34238918 hsa-mir-7641 Breast Neoplasms Carcinoma associated fibroblasts small extracellular vesicles with low miR-7641 promotes breast cancer stemness and glycolysis by HIF-1α. +genetics_knock down_promote 34238737 hsa-mir-4719 Breast Neoplasms ARHGAP36 overexpression significantly reversed the inhibitory effects of miR-4719 mimics on migration and invasion of breast cancer cells (P < 0.05). +circulation_biomarker_diagnosis_down 34238731 hsa-mir-483 Ovarian Insufficiency, Premature Detection of serum miR +circulation_biomarker_diagnosis_up 34238666 hsa-let-7 Colonic Neoplasms The colon cancer cell lines were treated with plasmids or oligonucleotides to alter NEAT1, BACH1 and let-7 g-5p expression. +other 34238665 hsa-mir-454 Carcinoma, Hepatocellular 3p) and discs large homolog 5 (DLG5) was determined in tissues samples from the recruited patients with HCC. +genetics_overexpression_suppress 34238324 hsa-mir-585 Ovarian Neoplasms, High-Grade Serous Overexpression of CAPN9 reduced the inhibitory effect of miR +target gene 34238300 hsa-mir-146 Urinary Bladder Neoplasms LncRNA HAND2-AS1 exerts anti-oncogenic effects on bladder cancer via restoration of RARB as a sponge of microRNA-146. +lncRNA target 34238213 hsa-mir-145 Stomach Neoplasms CONCLUSIONS UCA1 accelerated cell proliferation and inhibited cell apoptosis through sponging miR-145 to upregulate MYO6 expression in gastric cancer, indicating that the UCA1/miR-145/MYO6 axis may serve as a potential therapeutic target for gastric cancer. +genetics_knock down_promote 34238206 hsa-mir-182 Angelman Syndrome 5p overexpression and RASA1 knockdown reversed the effects of circMTO1 overexpression on the proliferation, migration, and apoptosis of ox-LDL-stimulated VSMCs. +genetics_overexpression_promote 34238196 hsa-mir-125b Colonic Neoplasms Overexpression of miR-125b inhibited proliferation and promoted apoptosis in SW480 colon cancer cells and was accompanied by upregulated Bax expression and downregulated Bcl-2 expression (P<0.05). +circulation_biomarker_prognosis_up 34238179 hsa-mir-133a Breast Neoplasms CONCLUSION: Plasma levels of miR-155, miR-133a, miR-21 and miR-205 may be useful as prognostic and follow-up markers for breast cancer with further validation in a large cohort of patients. +circulation_biomarker_prognosis_up 34238179 hsa-mir-21 Breast Neoplasms CONCLUSION: Plasma levels of miR-155, miR-133a, miR-21 and miR-205 may be useful as prognostic and follow-up markers for breast cancer with further validation in a large cohort of patients. +circulation_biomarker_prognosis_up 34238179 hsa-mir-205 Breast Neoplasms CONCLUSION: Plasma levels of miR-155, miR-133a, miR-21 and miR-205 may be useful as prognostic and follow-up markers for breast cancer with further validation in a large cohort of patients. +circulation_biomarker_prognosis_up 34238179 hsa-mir-155 Breast Neoplasms CONCLUSION: Plasma levels of miR-155, miR-133a, miR-21 and miR-205 may be useful as prognostic and follow-up markers for breast cancer with further validation in a large cohort of patients. +lncRNA target 34238170 hsa-mir-27b Stomach Neoplasms CONCLUSION: MiR-27b-3p was down-regulated in GC, and it could regulate Hippo pathway and affect EMT by inhibiting RUNX1 expression. +genetics_GWAS 34238140 hsa-mir-193 Triple Negative Breast Neoplasms At the epigenetic level, TNBC is characterized by epigenetic signatures, such as DNA methylation, histone remodeling, and a host of miRNA, MiR-193, LncRNA, HIF- 2alpha, eEF2K, LIN9/NEK2, IMP3, LISCH7/TGF-beta1, GD3s, KLK12, mediated regulation. +genetics_overexpression_promote 34238129 hsa-mir-145 Prostatic Neoplasms PLD5 overexpression exerted a cancerous effect while mimicking of miR +lncRNA target 34237985 hsa-mir-138 Neuralgia Western blotting showed that the protein expressions of MIP-1alpha and CCR1 in pSNL miRNA138 mimic group were significantly decreased on day 7. CONCLUSIONS: Intrathecal injection of miRNA-138 can remarkably alleviate NP in rats with a pSNL, which may be achieved by suppressing the TLR4 and MIP-1alpha/CCR1 signaling pathways. +circulation_biomarker_diagnosis_down 34237753 hsa-mir-27a Pulpitis A high level of TLR4 was also detected in both peripheral blood monocytes and pulp tissues from pulpitis patients and showed a negative association with the miR-27a-3p level. +transcription factor target 34237654 hsa-mir-20a Leukemia Additionally, their alteration may be related to CD8(+) T cell dysfunction in CML patients; thus, NFAT2 and miR-20a-5p may be considered potential targets for revising T cell function in leukemia immunotherapy. +circulation_biomarker_diagnosis_ns 34237654 hsa-mir-20a Nephritis, Interstitial We further demonstrate that the NFAT2-induced activation, differentiation, and expression of cytokines in human umbilical cord blood CD8(+) naive T cells are miR-20a-5p dependent. +transcription factor target 34237654 hsa-mir-20a Leukemia, Myelogenous, Chronic, BCR-ABL Positive Additionally, their alteration may be related to CD8(+) T cell dysfunction in CML patients; thus, NFAT2 and miR-20a-5p may be considered potential targets for revising T cell function in leukemia immunotherapy. +lncRNA target 34237642 hsa-mir-133a Inflammation In contrast, miR-133a decreased significantly apoptosis and inflammation in the cells. Overall, results indicated that circ08409 could relieve the inhibitory effect of miR-133a on TGFB2 expression by combining with miR-133a and subsequently modulating cell proliferation, apoptosis and inflammation. +other 34237309 hsa-mir-223 Prostatic Neoplasms 3p in promoting radiotherapy resistance of PCa cells by activating glycolysis. +lncRNA target 34237299 hsa-mir-4677 Glioma Our data showed that GLIDR affects the proliferation and apoptosis of glioma cells by targeting miR3p to regulate the expression of MAGI2. +other 34236827 hsa-mir-22 Adenocarcinoma of Lung 3p may be involved in the tumor progression of lung adenocarcinoma and may serve as a biomarker for the diagnosis and prognosis of lung adenocarcinoma. +genetics_overexpression_suppress 34236826 hsa-mir-373 Uterine Cervical Neoplasms AKT1 overexpression rescued the proliferation of cervical cancer cells transfected with miR +lncRNA target 34236821 hsa-mir-128 nonobstructive coronary artery disease Conclusion: Thus, lncRNA AF131217.1 promoted inflammation in the regulated CSF via KLF4 by miR3p. +lncRNA target 34236760 hsa-let-7b Lung Neoplasms The results suggest that this aerosolized let-7b mimic is a promising approach for lung cancer prevention, and that the in vivo tumor inhibitory effects of let-7b are mediated, at least in part, by immune-promoting effects via downregulating PD-L1 in tumors and/or PD-1 on CD8+ T cells. +other 34236626 hsa-mir-19a Nasopharyngeal Carcinoma Based on the growth-related modules of NPC cells, we have obtained a series of non-coding RNAs (ncRNAs) including microRNA-92a-3p, microRNA-19a-3p and microRNA-130a-3p, play an important role in regulating the growth of NPC cells. +other 34236626 hsa-mir-92a Nasopharyngeal Carcinoma Based on the growth-related modules of NPC cells, we have obtained a series of non-coding RNAs (ncRNAs) including microRNA-92a-3p, microRNA-19a-3p and microRNA-130a-3p, play an important role in regulating the growth of NPC cells. +other 34236626 hsa-mir-130a Nasopharyngeal Carcinoma Based on the growth-related modules of NPC cells, we have obtained a series of non-coding RNAs (ncRNAs) including microRNA-92a-3p, microRNA-19a-3p and microRNA-130a-3p, play an important role in regulating the growth of NPC cells. +other 34236362 hsa-mir-9 Stomach Ulcer The results showed that CPS-II could reduce oxidative stress and inflammatory response by regulating the miR5p-MEK/ERK signaling pathway, thus protecting the gastric mucosa and improving stress gastric ulcers. +transcription factor target 34236149 hsa-mir-675 Carcinoma, Hepatocellular CONCLUSIONS: The EGFR-P38 MAPK axis could up-regulate PD-L1 through miR5p and down-regulate HLA-ABC via HK2 in HCC cells. +genetics_overexpression_promote 34236145 hsa-mir-578 Adenocarcinoma of Lung CONCLUSIONS: In summary, our data show that the overexpression of hsa_circ_0008274 repressed the proliferation and invasion of LUAD through downregulating miR-578 and activating HMGA2. +genetics_knock down_promote 34236115 hsa-mir-224 Mouth Neoplasms 5p inhibitor-transfected amoeboid-like CD44(high) OSCC cells exhibited significant enhancement of the proportion of apoptotic cells; however, this effect was significantly inhibited by knockdown of PANX1 with PANX1 small interfering RNA. +genetics_GWAS 34235620 hsa-mir-544a Colorectal Neoplasms In this study, we investigated the KRAS status in correlation with clinicopathological features in sporadic CRC and more importantly the role of let-7a-5p and miR-544a-3p in the regulation of wild-type KRAS protein expression in the tumor center (T1) and invasive tumor front (T2). Our results suggest the role of the KRAS-LCS6 polymorphism and miR-544a-3p expression in the regulation of wild-type KRAS protein expression in sporadic CRC. +genetics_overexpression_promote 34235595 hsa-mir-122 Pancreatitis These results provided evidence that miR-122 overexpression impaired intestinal barrier function via regulation of occludin expression, thus promoting AP progression. +transcription factor target 34235224 hsa-mir-200a Liver Cirrhosis Based on the data from GSE14323, the expression of EGFR, STAT3, CTNNB1, and TP53 targeted by miR-200a-3p was significantly downregulated in fibrotic liver samples. In conclusion, it is demonstrated that miR-20a-5p and miR-200a-3p were identified as the novel liver fibrosis-associated miRNAs, which may play critical roles in liver fibrogenesis. +exosome 34234888 hsa-mir-384 Acute Lung Injury Therefore, exosomal miR5p could be demonstrated as a promising therapeutic strategy for ALI/ARDS. +lncRNA target 34234865 hsa-mir-519b Colorectal Neoplasms Furthermore, we found that SNHG14 functions as a sponge for miR-519b-3p, while the DEAD box protein 5 (DDX5) is a downstream target gene of miR-519b-3p, and the functions of miR-519b-3p inhibitors on the CRC progression could be rescued by downregulation of DDX5. Our findings suggest that SNHG14 promotes the CRC progression by miR-519b-3p/DDX5 axis, implying the promising therapeutic target of SNHG4 for CRC patients. +genetics_overexpression_promote 34234863 hsa-mir-124 Nasopharyngeal Carcinoma Overexpression miR +other 34234862 hsa-mir-127 Stomach Neoplasms circALPL Sponges miR-127 to Promote Gastric Cancer Progression by Enhancing MTDH Expression. +lncRNA target 34234851 hsa-mir-203 Carcinoma, Hepatocellular Conclusion: Our study suggested that miR-203 could be a novel predictor in early-stage HCC and might also be a potential molecular target for HCC therapy. +lncRNA target 34234811 hsa-mir-431 Intervertebral Disc Degeneration 5p/DISC1 is involved in the pathogenesis of IDD, which might be helpful in determining the diagnostic biomarkers and providing potential therapeutic targets for patients with IDD. +other 34234808 hsa-mir-1184 Urinary Bladder Neoplasms In conclusion, the circCA12/miRNA-1184/RAS family was identified as a regulatory axis in UBC progression. +transcription factor target 34234781 hsa-mir-182 Allergic Inflammation MiR5p mimic inhibited allergic inflammation both in vitro and in vivo. +target gene 34234564 hsa-mir-567 Uterine Cervical Neoplasms Hsa_circRNA_000543 Predicts Poor Prognosis and Promotes Cervical Cancer Cell Progression Through Regulating miR-567/ZNF268 Axis. +other 34234557 hsa-mir-1224 Glioma 3p-MELK, that regulate the pathogenesis of LGG were ultimately identified. +target gene 34234553 hsa-mir-1245b Prostatic Neoplasms Long Noncoding RNA AATBC Promotes the Proliferation and Migration of Prostate Cancer Cell Through miR-1245b-5p/CASK Axis. +transcription factor target 34234551 hsa-mir-212 Carcinoma, Hepatocellular 3p/SLC6A1 axis could serve as a crucial therapeutic target for HCC. +genetics_overexpression_promote 34234548 hsa-mir-758 Stomach Neoplasms The overexpression of miR-758 neutralized the ZNF217-mediated effects on facilitating the progression of GC. +other 34234459 hsa-mir-29b Choriocarcinoma The RT-PCR results confirmed that miR-29b-3p was highly expressed and that miR-519c-3p and miR-520a-5p were expressed at low levels in choriocarcinoma cells. +other 34234459 hsa-mir-520a Choriocarcinoma The RT-PCR results confirmed that miR-29b-3p was highly expressed and that miR-519c-3p and miR-520a-5p were expressed at low levels in choriocarcinoma cells. +other 34234459 hsa-mir-519c Choriocarcinoma The RT-PCR results confirmed that miR-29b-3p was highly expressed and that miR-519c-3p and miR-520a-5p were expressed at low levels in choriocarcinoma cells. +transcription factor target 34234438 hsa-mir-126a Ischemic Stroke CONCLUSION: MiR-126a-5p is a novel potential target for ischemic stroke therapy due to its protection against cerebral I/R injury via directly targeting NOX2. +transcription factor target 34233850 hsa-mir-335 Non-alcoholic Fatty Liver Disease 5p had inhibitory effect on the development of NASH. +circRNA target 34233716 hsa-mir-15b Diabetic Retinopathy CONCLUSION: Upregulation of circ_001209 contributes to vascular dysfunction in diabetic retinas through regulating miR-15b-5p and COL12A1, providing a potential treatment strategy for diabetic retinopathy. +genetics_overexpression_suppress 34233701 hsa-mir-30 Intervertebral Disc Degeneration Moreover, the overexpression of miR +other 34233694 hsa-mir-126 Diabetes Mellitus a correlated with wound healing. +other 34233694 hsa-mir-21 Diabetes Mellitus a correlated with wound healing. +other 34233694 hsa-mir-1 Diabetes Mellitus a correlated with wound healing. +other 34233694 hsa-mir-99b Diabetes Mellitus a correlated with wound healing. +other 34233673 hsa-mir-21 COVID-19 5p in the regulation of pro-inflammatory genes in CHPV infected human microglial cells. +target gene 34233668 hsa-mir-513c Breast Neoplasms CONCLUSION: MiR-513c and miR-3163 were downregulated in BC tissues, which might serve as tumor suppressors. +target gene 34233668 hsa-mir-3163 Breast Neoplasms CONCLUSION: MiR-513c and miR-3163 were downregulated in BC tissues, which might serve as tumor suppressors. +other 34233591 hsa-let-7e Diabetes, Gestational 5p and downregulated expression of SGOL1, RRM2, RGS5, CDK1 and CENPA. +genetics_knock down_promote 34233586 hsa-mir-145 Uterine Cervical Neoplasms KLF5-induced overexpression of DANCR promotes CC progression via suppressing miR +genetics_knock down_promote 34233454 hsa-mir-21 Plaque, Atherosclerotic Mir21 knockout in bone marrow cells also reduced atherosclerosis and necrotic core size. +genetics_overexpression_promote 34233436 hsa-mir-23a Diabetes Mellitus, Type 2 Only miR-23a-3p was significantly overexpressed in the diabetes group compared with the control group (DPP-4 inhibitor vs. control, p = 0.01; sulfonylurea vs. control, p = 0.007). The miR-23a levels were higher in diabetic participants than in nondiabetic controls. +exosome 34233294 hsa-mir-944 Glioma These findings demonstrate that GSC-derived exosomal miR-944 inhibits glioma growth, progression, and angiogenesis by suppressing VEGFC expression and inhibiting the AKT/ERK signaling pathway. +exosome 34233088 hsa-mir-619 Carcinoma, Hepatocellular CONCLUSION: The exosome circCMTM3/miR5p/SOX9 axis from HCC cells promotes angiogenesis and thus contributes to HCC tumorigenesis. +lncRNA target 34232945 hsa-mir-345 Cholangiocarcinoma The E2F1/LMCD1-AS1/miR5p/COL6A3 axis is a newly identified regulatory mechanism, which has a function in cholangiocarcinoma (CCA) tumorigenesis and progression and provides potential therapeutic targets for CCA. +lncRNA target 34232945 hsa-mir-106b Osteosarcoma LMCD1-AS1 modulates the survival of osteosarcoma via targeting miR-106b-5p. +lncRNA target 34232945 hsa-mir-1287 Hypoadrenocorticism, Familial In THCA development, LMCD1-AS1 exerts protumorigenic function through sponging miR +genetics_knock down_promote 34232917 hsa-mir-181c Adenocarcinoma of Lung Knockdown of LINC00665 induced obvious inhibitions in cell viability, clone formation, invasion and tumorigenesis in LUAD cells, whereas miR-181c-5p downregulation significantly neutralized these effects. +lncRNA target 34232796 hsa-mir-26a Penile Neoplasms These results suggest that miR-26a might regulate HPV-positive progression from CA to PSCC through modulating PTEN. +other 34232332 hsa-mir-29b Esophageal Squamous Cell Carcinoma CONCLUSION: Silencing of miR-29b in ESCC cells can increase expression of BTG2 and decrease the level of intracellular cyclin D1, resulting in cell cycle arrest and accumulation in the G0/G1 phase. +lncRNA target 34232111 hsa-mir-146a Prostatic Neoplasms Moreover, the inhibition of miR-146a-5p partially counteracted the effects of lncRNA CRNDE on PC cell proliferation, migration, and invasion. In conclusion, lncRNA CRNDE may serve as a cancer promoter in PC by targeting miR-146a-5p. +transcription factor target 34231397 hsa-mir-148a Irritable Bowel Syndrome Acupuncture might downregulate miR-148a-3p through multiple pathways to alleviate or relieve IBS-D symptoms. +transcription factor target 34231241 hsa-mir-622 Prostatic Neoplasms Findings demonstrate a novel mechanism by which miR-622 modulates PCa cells' metastasis by targeting metastatic genes. These data confirm the tumour-suppressive function of miR-622 in PCa cells by enhancing apoptosis and reducing metastasis. +genetics_knock down_promote 34231101 hsa-mir-345 Carcinoma, Hepatocellular CONCLUSION: Circ-STIL knockdown suppressed HCC development by regulating miR +other 34230985 hsa-mir-394 Eye Diseases MiR394 plays a negative role in tomato resistance to late blight. +genetics_knock down_promote 34230950 hsa-mir-30 Carcinoma, Non-Small-Cell Lung Circ_0001666 knockdown reduced the cell viability and promoted the apoptosis of NSCLC cells, which could be reversed by miR +genetics_knock down_promote 34230481 hsa-mir-455 Cartilage Diseases Furthermore, knockdown of HIF-2alpha in 6-month-old miR-455 knockout cartilage rescues the elevated expression of cartilage degeneration-related genes. +genetics_knock down_promote 34230224 hsa-mir-365 Glioma Knockdown of PVT1 and overexpression of miR-365 inhibited proliferation, migration, invasion and promoted stemness and Temozolomide (TMZ) resistance of glioma cells. +lncRNA target 34230221 hsa-mir-579 Pancreatic Carcinoma CONCLUSIONS: Our observations highlighted that HCG11 contributed to the progression of pancreatic carcinoma by promoting growth and aggressiveness, and inhibiting apoptosis via miR3p/MDM2/Notch/Hes1 axis. +other 34229821 hsa-mir-590 Uterine Cervical Neoplasms And the role of Mir3P in the development and progression of cervical cancer. +genetics_knock down_promote 34229645 hsa-mir-4500 Colonic Neoplasms Restored MAP3K13 expression or miR-4500 knockdown partially abrogated the effects of silencing LINC01287 in colon cancer cells. CONCLUSION: Our findings demonstrated that the LINC01287/miR-4500/MAP3K13 axis promoted progression of colon cancer. +exosome 34229586 hsa-mir-141 Intervertebral Disc Degeneration Taken together, we concluded that PRP secreted exosomal miR3p to activate the Keap1-Nrf2 pathway, which helped to slow down IVD degeneration. +other 34229450 hsa-mir-145 Uterine Cervical Neoplasms Conclusion: The rs3733846 in the flanking region of miR-143/145 was related to the susceptibility of CSCC. +other 34229450 hsa-mir-143 Uterine Cervical Neoplasms Conclusion: The rs3733846 in the flanking region of miR-143/145 was related to the susceptibility of CSCC. +other 34229300 hsa-mir-424 Osteoporosis Our findings may bring evidence for miR5p as a new biomarker for the treatment of osteoporosis. +lncRNA target 34228857 hsa-mir-382 Bronchopulmonary Dysplasia 5p may suppress M1 macrophage activation and inflammatory response via inhibiting CDK8, thereby regulating the development of BPD, which is possibly mediated by STAT1 signaling. +genetics_knock down_promote 34228643 hsa-mir-26a Depression The knockdown of miR-26a-3p in DG regions of normal control rats induced depression-like behaviors, effects that were accompanied by activation of the PTEN/PI3K/Akt signaling pathway and neuronal deterioration via suppression of autophagy, impairments in synaptic plasticity, and promotion of neuronal apoptosis. +genetics_knock down_suppress 34228494 hsa-mir-335 Hypertrophy Gain- and loss-function assays were performed to determine the role of SNHG20/miR-335/Galectin-3 in cardiac fibrosis. Our study revealed that downregulation of SNHG20 improved angiotensin II-induced cardiac fibrosis by targeting the miR-335/Galectin-3 axis, suggesting that SNHG20 is a therapeutic target for cardiac fibrosis and hypertrophy. +genetics_knock down_suppress 34228494 hsa-mir-335 Cardiomyopathies Gain- and loss-function assays were performed to determine the role of SNHG20/miR-335/Galectin-3 in cardiac fibrosis. Our study revealed that downregulation of SNHG20 improved angiotensin II-induced cardiac fibrosis by targeting the miR-335/Galectin-3 axis, suggesting that SNHG20 is a therapeutic target for cardiac fibrosis and hypertrophy. +other 34228324 hsa-mir-346 Carcinoma, Non-Small-Cell Lung Taken together, circ_0069244 restrained NSCLC progression by modulating the miR5p/XPC axis. +other 34228237 hsa-let-7a Osteoporosis In OP samples, miRNA let-7a-5p was notably declined while RNA KCNQ1OT1 were remarkably up-regulated. +other 34227918 hsa-mir-34a Takotsubo Cardiomyopathy This rat model may provide a useful tool for investigating the causal relationship between miR-34a expression, mitochondrial (dys)function, and cardiac alterations under stressful conditions, which could have important implications in the context of stress-related cardiac disease. +other 34227918 hsa-mir-34a Heart Diseases This rat model may provide a useful tool for investigating the causal relationship between miR-34a expression, mitochondrial (dys)function, and cardiac alterations under stressful conditions, which could have important implications in the context of stress-related cardiac disease. +lncRNA target 34227845 hsa-mir-98 Ischemic Stroke In conclusion, our data demonstrated that XIST facilitated the progression of ischemic stroke through regulating the miR-98/BACH1 axis. +other 34227673 hsa-let-7a Adenomyosis These data suggested that 17betaestradiol collaborates with the let7a/Lin28B axis to affect the development of ADS. +genetics_knock down_suppress 34227151 hsa-mir-4458 Breast Neoplasms Circ_0001667 knockdown blocks cancer progression and attenuates ADM resistance by depleting NCOA3 via releasing miR-4458 in breast cancer. +lncRNA target 34227092 hsa-mir-101 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: FAM201A could target miR-101 and upregulate Vimentin to inhibit lung cancer progression. +genetics_overexpression_suppress 34226687 hsa-mir-34a Prostatic Neoplasms We found that miR-34a overexpression significantly inhibited the cell cycle, viability, and migration of PCa cells by targeting its downstream genes. +transcription factor target 34226680 hsa-mir-21 Colorectal Neoplasms Our results identify a novel molecular loop involving MIR21 dysregulation, JAM-A silencing and activation of multiple oncogenic pathways in promoting invasiveness and metastasis in CRC. +other 34226620 hsa-mir-17 Prostatic Neoplasms 5p was an independent negative prognostic factor in PCa. +transcription factor target 34226586 hsa-mir-1246 Neoplasm Metastasis Among the soluble factors secreted from highly metastatic tumors, we focused on EVs and determined that miR-1246 was contained at a higher level in highly metastatic tumor EVs than in low metastatic tumor EVs. These results suggested that highly metastatic tumors induce drug resistance in ECs by transporting miR-1246 through EVs. +lncRNA target 34226568 hsa-mir-137 Schizophrenia Receiver operating characteristic (ROC) analysis showed that the miR-137 expression signature could be used to discriminate between patients with EOS and healthy controls (AUC = 0.911). Moreover, miR-137 dysregulation was correlated with almost all NSS subscales (i.e., sensory integration, motor sequencing, etc.) and, when EOS patients with NSS, miR-137 expression discriminated these patients from healthy controls to a greater extent (AUC = 0.957). +other 34226568 hsa-mir-34c Schizophrenia Differential expression analysis revealed that miR-137, miR-34b, and miR-34c were significantly up-regulated in patients with schizophrenia and their unaffected first-degree relatives compared to healthy controls. +other 34226568 hsa-mir-34b Schizophrenia Additionally, miR-34b had the highest ability to discriminate between EOS and AOS (AUC = 0.810), which may indicate different aetiological pathways to disease onset. +other 34226539 hsa-mir-335 Adenocarcinoma of Lung 5p/NLRP1/NLRP7 regulatory axis, which may also play an important role in the progression of LUAD. +lncRNA target 34226535 hsa-mir-133a Hypertrophy The inhibition of the miR-133a on cardiac proliferation and hypertrophy could be prevented by silencing of Fto (FTO alpha-ketoglutarate dependent dioxygenase) which induced m6A modification. +lncRNA target 34226533 hsa-mir-127 Thyroid Cancer, Papillary In short, our findings indicated that LINC00284-miR5p-E2F7 axis exerted oncogenic properties in PTC and may offer a new promising target for the diagnosis and therapy of PTC. +circRNA target 34226531 hsa-mir-567 Colorectal Neoplasms Our findings clarified the Circ_0030998/miR-567/VEGFA regulation axis and indicated that Circ_0030998 could be a potential therapeutic target for CRC. +other 34226522 hsa-mir-4766 Esophageal Neoplasms 5p/LAMA1 axis functions as an oncogenic factor in promoting ESCC cell proliferation, migration, and invasion by inducing EMT, implying its potential prognostic and therapeutic significance in ESCC. +lncRNA target 34226413 hsa-mir-127 Colorectal Neoplasms Our research reveals that LINC00174 affected the biological characteristics of CRC cells through regulated miR +lncRNA target 34226299 hsa-mir-144 Colorectal Neoplasms 3p inhibited ZEB1 and ZEB2 expression and was negatively correlated with their expression in CRA. +genetics_knock down_promote 34226297 hsa-mir-9 Stomach Neoplasms In conclusion, ZNRD1-AS1 levels were upregulated in gastric cancer tissues, and knockdown of ZNRD1-AS1 suppressed gastric cancer cell proliferation and metastasis by targeting the miR5p/HSP90AA1 axis. +target gene 34225726 hsa-mir-134 Breast Neoplasms Ruyiping formula inhibits metastasis via the microRNA-134-SLUG axis in breast cancer. +genetics_knock down_promote 34225723 hsa-mir-133a Glioblastoma CONCLUSION: Tim-1 knockdown inhibited glioblastoma cell proliferation, invasion, and migration through the miR-133a/TGFBR1 axis and restrained the activation of the Wnt/beta-catenin pathway. +lncRNA target 34225636 hsa-mir-485 Melanoma CONCLUSION: Together, these results suggest that MIR155HG is capable of promoting melanoma cell proliferation via the miR +lncRNA target 34225531 hsa-mir-15a Pterygium CONCLUSIONS: Our study demonstrated that decreased expression of miR-15a in pterygium might be associated with the apoptosis and proliferation of abnormal cell via regulating BCL-2, which could subsequently contribute to the development of pterygium. +other 34225433 hsa-mir-495 Carcinoma, Hepatocellular In addition, miR-495 has a certain effect on the proliferation and migration ability of MHCC-97H HCC cells. +lncRNA target 34225215 hsa-mir-198 Stomach Neoplasms MiR-198 inhibitor reversed the effect of circPLEC downreguAlation in PTX-resistant GC cells, and MUC19 downregulation weakened GC resistance to PTX and tumorigenesis and improved the apoptosis of PTX-resistant GC cells. In summary, circPLEC acts as a sponge of miR-198 to promote the PTX resistance and tumorigenesis of GC cells by regulating MUC19 expression. +other 34224858 hsa-mir-155 Immune-Mediated Inflammatory Diseases Although the results were not so prominent in NAFLD, miR-155 displayed a downward trend in the placebo group (p = 0.054) whereas the levels did not changed significantly in the Mastiha group in patients with less advanced fibrosis. +lncRNA target 34224818 hsa-mir-181c Ischemic Stroke CONCLUSION: Our results indicated that SNHG14 promoted neurons injury through regulating miR-181c-5p/BMF axis, suggesting that SNHG14 might be a potential target to alleviate IS-induced brain injury. +lncRNA target 34224325 hsa-mir-143 Uterine Cervical Neoplasms Overall, the data indicated that the MEOX2-AS1/miR3p/VDAC1 pathway participated in CC progression, making it a novel therapeutic target for CC cures. +other 34224319 hsa-mir-149 Brain Ischemia, Acute 5p and provide references for the treatment of neurological diseases, 60 male SD rats aged 7-8 weeks were selected and divided randomly into test group (establishing middle cerebral artery occlusion (MCAO) model) and control group (no modeling). +circRNA target 34224315 hsa-mir-580 Osteosarcoma CircRAB3IP promotes OS cells proliferation, migration, and invasion through modulating miR +lncRNA target 34224294 hsa-mir-625 Stomach Neoplasms In conclusion, LINC00511 promotes the GC cell proliferation and migration via targeting the miR +genetics_overexpression_suppress 34223779 hsa-mir-1231 Carcinoma, Non-Small-Cell Lung Overexpression of miR-1231 inhibited NSCLC cell proliferation, migration and invasion. +genetics_overexpression_promote 34223709 hsa-mir-383 Liver Neoplasms HULC and VAMP2 were overexpressed whereas miR +genetics_overexpression_promote 34223709 hsa-mir-383 Carcinoma, Hepatocellular HULC and VAMP2 were overexpressed whereas miR +lncRNA target 34222668 hsa-mir-655 Retinoblastoma 3p downstream target ATPase Family AAA Domain Containing 2 (ATAD2). +genetics_overexpression_suppress 34222652 hsa-mir-126 Vascular Diseases The expression of miR-126 is downregulated in a variety of vascular diseases, and miR-126 overexpression appears to beneficial for most vascular disease models. +other 34222420 hsa-mir-671 Colorectal Neoplasms After verifying the identified mRNA effect in the TCGA database, we finally recognized 3 mRNAs (CA2, ITLN1 and LRRC19) that were significantly associated with the overall survival of CRC patients and constructed a ceRNA subnetwork including 5 circRNAs (hsa_circ_0080210, hsa_circ_0007158, hsa_circ_0000375, hsa_circ_0018909 and hsa_circ_0011536) and 3 miRNAs (hsa-miR-601, hsa-miR5p and hsa-miR-765), which could contain innovative and noninvasive indicators for the early screening and prognostic prediction of CRC. +other 34222420 hsa-mir-765 Colorectal Neoplasms After verifying the identified mRNA effect in the TCGA database, we finally recognized 3 mRNAs (CA2, ITLN1 and LRRC19) that were significantly associated with the overall survival of CRC patients and constructed a ceRNA subnetwork including 5 circRNAs (hsa_circ_0080210, hsa_circ_0007158, hsa_circ_0000375, hsa_circ_0018909 and hsa_circ_0011536) and 3 miRNAs (hsa-miR-601, hsa-miR5p and hsa-miR-765), which could contain innovative and noninvasive indicators for the early screening and prognostic prediction of CRC. +other 34222420 hsa-mir-601 Colorectal Neoplasms After verifying the identified mRNA effect in the TCGA database, we finally recognized 3 mRNAs (CA2, ITLN1 and LRRC19) that were significantly associated with the overall survival of CRC patients and constructed a ceRNA subnetwork including 5 circRNAs (hsa_circ_0080210, hsa_circ_0007158, hsa_circ_0000375, hsa_circ_0018909 and hsa_circ_0011536) and 3 miRNAs (hsa-miR-601, hsa-miR5p and hsa-miR-765), which could contain innovative and noninvasive indicators for the early screening and prognostic prediction of CRC. +lncRNA target 34222341 hsa-mir-378a Osteosarcoma Rescue assays showed that SSH2 upregulation or miR-378a-3p inhibition counteracted the inhibitory effect of LINC00174 depletion in OS cell growth. +lncRNA target 34222244 hsa-mir-29a Reperfusion Injury, Testicular Ischemia In summary, our research indicates that MEG3 contributes to pyroptosis by regulating miR-29a and PTEN during testicular I/R, indicating that MEG3 may be a potential therapeutic target in testicular torsion. +circulation_biomarker_prognosis_down 34222137 hsa-mir-607 Carcinoma, Pancreatic Ductal CONCLUSIONS: Low serum miR-607 level may serve as a potential diagnostic and prognostic biomarker through regulation of tumor metastasis in PDAC patients. +target gene 34221989 hsa-mir-497 Breast Neoplasms LncRNA FGD5-AS1 Facilitates the Radioresistance of Breast Cancer Cells by Enhancing MACC1 Expression Through Competitively Sponging miR-497-5p. +transcription factor target 34221869 hsa-mir-21 Liver Neoplasms Mechanistically, LIX1L increased miR3p expression, which targeted and suppressed FBP1, thereby promoting HCC growth and metastasis. +other 34221706 hsa-mir-195 Vasospasm, Intracranial 5p can potentially be used to manage SAH-induced cerebral vasospasm and brain injury. +other 34221706 hsa-mir-195 Subarachnoid Hemorrhage 5p can potentially be used to manage SAH-induced cerebral vasospasm and brain injury. +other 34221706 hsa-mir-195 Brain Injuries 5p can potentially be used to manage SAH-induced cerebral vasospasm and brain injury. +circulation_biomarker_diagnosis_ns 34221208 hsa-mir-155 Rhinitis, Allergic CONCLUSION: MiR-155 expression levels were elevated in the serum of AR children. +genetics_overexpression_promote 34221105 hsa-mir-18a Liver Neoplasms Overexpressing miR-18a-5p could promote the progression of liver cancer cells and inhibit cell apoptosis. miR-18a-5p and FBP1 are expected to be candidates for liver cancer treatment. +genetics_knock down_suppress 34221014 hsa-mir-124 Uterine Cervical Neoplasms In vivo assays, overexpression of miR-124, or knockdown of MALAT1 exhibited beneficial effects on tumor weight, size, and volume, together with elevating the survival rate, tightly related with the progression of cervical cancer. +genetics_overexpression_promote 34221007 hsa-mir-148b Irritable Bowel Syndrome Mimicking the IBS-exo treatment, miR-148b-5p overexpression increased cell permeability and downregulated RGS2 expression, which were abrogated by overexpressing RGS2. +transcription factor target 34220972 hsa-mir-181a Cardiomyopathies CONCLUSIONS: Downregulation of miR-181a-5p alleviates CME-induced myocardial damage by suppressing myocardial oxidative stress and inflammation through directly targeting XIAP. +other 34220948 hsa-mir-192 Stomach Neoplasms 3p. +circulation_biomarker_diagnosis_down 34220670 hsa-mir-1299 Meniere Disease miRNA-1299 was validated to be downregulated in both the serum and perilymph of Meniere's patients. +genetics_knock down_promote 34220411 hsa-mir-937 Hamartoma Syndrome, Multiple In contrast, inhibiting miR-937 impeded cells proliferation, promoted cells apoptosis and elevated levels of IL-6, IL-17 and TNF-alpha, which could be rescued by IL1B-knockdown in CSE-induced HBEs. +transcription factor target 34220338 hsa-mir-29a Sepsis Targeting miR-29a-5p may be a novel therapeutic strategy to suppress sepsis-induced vascular inflammation. +lncRNA target 34219538 hsa-mir-27a Asthma Role of miR-27a in the regulation of cellular function via the inhibition of MAP2K4 in patients with asthma. +genetics_knock down_suppress 34219377 hsa-mir-526b Carcinoma, Non-Small-Cell Lung Circ_0001821 knockdown reduced colony formation ability and metastasis ability but enhanced TAX sensibility and apoptosis of NSCLC cells, which was attenuated by miR-526b-5p inhibition or GRK5 overexpression. +genetics_knock down_promote 34219206 hsa-mir-338 Breast Neoplasms Circ-TFF1 knockdown suppressed BC progression by regulating miR +lncRNA target 34218800 hsa-mir-100 Ovarian Neoplasms 5p to inhibit the progression of OC. +genetics_GWAS 34218555 hsa-mir-452 Hearing Loss, Noise-Induced Objective: To investigate the relationship between rs1053005 of signal conversion and transcription activator 3 (STAT3) and miR3p, and the association between STAT3 gene polymorphism and noise-induced hearing loss (NIHL) . +exosome 34218459 hsa-mir-146a Hepatitis C In addition, miR-122 and miR-146a levels in extracellular exosomes from HCV-infected cells were dramatically increased whereas intracellular miR122 and miR-146a expression had no large changes. +exosome 34218459 hsa-mir-122 Hepatitis C In addition, miR-122 and miR-146a levels in extracellular exosomes from HCV-infected cells were dramatically increased whereas intracellular miR122 and miR-146a expression had no large changes. +exosome 34218325 hsa-mir-181a Nasopharyngeal Carcinoma CONCLUSION: This study concluded that hUC-MSCs-derived exosomal miR-181a retards NPC development via negatively modulating KDM5C, serving as a candidate reference for the therapy of NPC. +lncRNA target 34218270 hsa-mir-625 Melanoma Functional analysis of two SFPQ-enriched lncRNA, LINC00511 and LINC01234, demonstrated that these genes independently contribute to the melanoma phenotype and a more detailed analysis of LINC00511 indicated that this occurs in part via modulation of the miR5p/PKM2 axis. +genetics_GWAS 34218253 hsa-mir-155 Carcinoma, Renal Cell Our findings reveal that SNP-mediated lncRNA-ENTPD3-AS1 upregulation suppresses renal cell carcinoma via miR-155/HIF-1alpha signaling. +other 34218230 hsa-mir-449a Acute Kidney Injury INTRODUCTION: LincRNA-p21 is predicted to interact with miR-449a, which plays a protective role in cisplatin-induced acute kidney injury (CIA). +lncRNA target 34218230 hsa-mir-449a Arthritis INTRODUCTION: LincRNA-p21 is predicted to interact with miR-449a, which plays a protective role in cisplatin-induced acute kidney injury (CIA). CONCLUSION: Therefore, lincRNA-p21 is downregulated in CIA and may sponge miR-449a to inhibit cisplatin-induced apoptosis of HRPTEpCs. +circulation_biomarker_diagnosis_up 34218203 hsa-mir-20a Pre-Eclampsia The correlation between miR-320a expression and EOPE clinical indicators [mean arterial pressure (MAP), 24-h urinary protein excretion, serum creatinine (SCR), uric acid (UA), albumin (ALB) and platelet count] was analyzed. +exosome 34217892 hsa-mir-1246 Glioma 2-Methoxyestradiol suppresses MDSC activation by inhibiting hypoxia-driven exosomal miR-1246 expression in glioma cells and PD-L1 expression in MDSCs. +other 34216686 hsa-mir-627 Esophageal Squamous Cell Carcinoma 3p/TGFB2 signaling. +lncRNA target 34216580 hsa-mir-212 Spinal Cord Injuries 3p improved functional recovery of SCI rats and inhibited LPS-induced neurocyte apoptosis by targeting PTEN to activate AKT/mTOR pathway. +genetics_overexpression_promote 34216514 hsa-mir-92a Uterine Cervical Neoplasms Overexpression of PIK3R1 reversed the promotional effect of overexpressed miR-92a on the proliferation, migration, and invasion of cervical cancer. +circulation_biomarker_diagnosis_down 34216249 hsa-mir-101 Bradycardia The plasma levels of miR3p and miR-30a-5p were markedly downregulated in patients who experienced hypotension and bradycardia, respectively (P < 0.05). +circulation_biomarker_diagnosis_down 34216249 hsa-mir-101 Hypotension The plasma levels of miR +circRNA target 34215252 hsa-mir-758 Osteosarcoma RESULTS: Circ_0001721 and TCF4 were upregulated, whereas miR-758 was down-regulated in DXR-resistant OS tissues and cells. CONCLUSION: Circ_0001721 potentiated DXR resistance and facilitated the progression of OS by regulating miR-758/TCF4 axis, which provides promising therapeutic targets for OS treatment. +lncRNA target 34215132 hsa-mir-101 Alzheimer Disease miRNA-101, an Alzheimer-related biomarker, was used as a model target to validate the performance of the acoustic aggregation-induced separation assay. +lncRNA target 34214903 hsa-mir-146a Heart Transplant Rejection The purpose of this study was to investigate the effect of the interaction of the lncRNA PVT1 and miR-146a on Treg autophagy and reveal the mechanism to alleviate transplant rejection. +other 34213736 hsa-mir-100 Hypertension, Pregnancy-Induced MiR5p is revealed to be downregulated in gestational hypertension, while its underlying regulatory mechanism remains unclear. +other 34212978 hsa-mir-744 Diabetic Nephropathies In conclusion, the results of the present study suggested that the lncRNA HOTTIP may promote the fibrosis of lung tissues by downregulating the expression levels of miR7445p and upregulating the expression levels of PTBP1. +lncRNA target 34212977 hsa-mir-199a Varicose Veins In conclusion, miR199a5p may be a novel regulator of phenotypic switching in VSMCs by targeting FOXC2 during varicose vein formation. +other 34212545 hsa-mir-28 Asthma 3p in asthmatics sensitized to mulberry. +other 34212545 hsa-mir-28 Asthma, Allergic, Seasonal 3p in asthmatics sensitized to mulberry. +other 34212545 hsa-let-7d Asthma 3p in asthmatics sensitized to mulberry. +other 34212545 hsa-let-7d Asthma, Allergic, Seasonal 3p in asthmatics sensitized to mulberry. +genetics_overexpression_suppress 34212311 hsa-mir-21 Colorectal Neoplasms The activity of the Wnt/B-catenin pathway was assayed through measuring the expression of miR-135b, miR-21, and APC genes by real-time PCR. RESULTS: The results showed the downregulation of miR-135b and miR-21 and overexpression of the APC gene. +genetics_overexpression_suppress 34212311 hsa-mir-135b Colorectal Neoplasms The activity of the Wnt/B-catenin pathway was assayed through measuring the expression of miR-135b, miR-21, and APC genes by real-time PCR. RESULTS: The results showed the downregulation of miR-135b and miR-21 and overexpression of the APC gene. +genetics_overexpression_suppress 34212217 hsa-mir-1303 Porphyria, Variegate RESULTS: Football training down-regulates miR-1303 expression in muscle from VPG compared to CG and the expression of BAG-2, a chaperon protein involved in the autophagy pathway, inversely correlated to overexpression of miR-1303 in a time-dependent manner, indicating that it is a miR-1303 potential target. +circulation_biomarker_diagnosis_ns 34212044 hsa-mir-122 Hepatitis B, Chronic OBJECTIVE: To investigate the expression of microRNA-122 (miR-122) in the progression of chronic hepatitis B virus- (HBV-) infected liver diseases, thus determining the role of serum miR-122 as a marker of HBV-caused liver injury. +target gene 34211970 hsa-mir-335 Parkinson Disease miR-335 Targets LRRK2 and Mitigates Inflammation in Parkinson's Disease. +circulation_biomarker_diagnosis_up 34211838 hsa-mir-518f Adenocarcinoma of Lung Analysis of these circulating miRNAs in pleural mesothelioma cases confirmed that up-regulation of miR-518f-3p, +other 34211089 hsa-mir-200a Carcinoma, Ovarian Epithelial MiR-200a, a molecule that downregulates ZEB2, had the opposite effect of ZEB2 expression in EOC-CSLCs. +circulation_biomarker_diagnosis_ns 34209965 hsa-mir-146a Coronary Artery Disease Our results indicate that increased plasma levels of miR-146a-5p and miR +circulation_biomarker_diagnosis_ns 34209965 hsa-mir-21 Coronary Artery Disease Our results indicate that increased plasma levels of miR-146a-5p and miR +circulation_biomarker_diagnosis_ns 34209965 hsa-mir-17 Coronary Artery Disease Our results indicate that increased plasma levels of miR-146a-5p and miR +genetics_GWAS 34208765 hsa-mir-21 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: Our study provides interesting insights on the role of circulating miRNAs, in particular miR-21, and their dynamic change over time in predicting EGFR-TKI response in EGFR-mutated NSCLC. +circulation_biomarker_diagnosis_up 34208452 hsa-mir-221 Acute Coronary Syndrome RESULTS: The study data showed significant down regulation in the expression of the serum levels of FENDRR lncRNA and miRNA +circulation_biomarker_diagnosis_up 34208452 hsa-mir-197 Acute Coronary Syndrome RESULTS: The study data showed significant down regulation in the expression of the serum levels of FENDRR lncRNA and miRNA +other 34206912 hsa-mir-27b Hemochromatosis In parallel, muscle-specific myomiR analysis described upregulation of miR-27b and miR-499 and down-regulation of miR-1a, miR-133a, miR-133b, and miR-206 in both the 200 and 300 mug/kg GHBP groups. +other 34206912 hsa-mir-1a Hemochromatosis In parallel, muscle-specific myomiR analysis described upregulation of miR-27b and miR-499 and down-regulation of miR-1a, miR-133a, miR-133b, and miR-206 in both the 200 and 300 mug/kg GHBP groups. +other 34206912 hsa-mir-206 Hemochromatosis In parallel, muscle-specific myomiR analysis described upregulation of miR-27b and miR-499 and down-regulation of miR-1a, miR-133a, miR-133b, and miR-206 in both the 200 and 300 mug/kg GHBP groups. +other 34206912 hsa-mir-499 Hemochromatosis In parallel, muscle-specific myomiR analysis described upregulation of miR-27b and miR-499 and down-regulation of miR-1a, miR-133a, miR-133b, and miR-206 in both the 200 and 300 mug/kg GHBP groups. +other 34206912 hsa-mir-133a Hemochromatosis In parallel, muscle-specific myomiR analysis described upregulation of miR-27b and miR-499 and down-regulation of miR-1a, miR-133a, miR-133b, and miR-206 in both the 200 and 300 mug/kg GHBP groups. +other 34206912 hsa-mir-133b Hemochromatosis In parallel, muscle-specific myomiR analysis described upregulation of miR-27b and miR-499 and down-regulation of miR-1a, miR-133a, miR-133b, and miR-206 in both the 200 and 300 mug/kg GHBP groups. +other 34206682 hsa-mir-191 Anorexia Nervosa 5p was increased in the NAR group. +other 34206682 hsa-mir-181d Anorexia Nervosa 5p was increased in the NAR group. +other 34206682 hsa-mir-181d Aortic Valve Insufficiency 5p was increased in the NAR group. +other 34206682 hsa-mir-150 Anorexia Nervosa 5p could be related to an increased MBD6 whose deregulation could have clinical consequences. +other 34206682 hsa-mir-191 Aortic Valve Insufficiency 5p was increased in the NAR group. +other 34206682 hsa-mir-150 Aortic Valve Insufficiency 5p could be related to an increased MBD6 whose deregulation could have clinical consequences. +circulation_biomarker_diagnosis_up 34206143 hsa-mir-29a Carcinoma, Hepatocellular Serum MIR29A of HCC patients showed decreased levels as compared to that of normal control, with an area under curve (AUC) of 0.751 of a receiver operating characteristic (ROC) curve. +circulation_biomarker_diagnosis_up 34206143 hsa-mir-29 Carcinoma, Hepatocellular Serum MIR29A of HCC patients showed decreased levels as compared to that of normal control, with an area under curve (AUC) of 0.751 of a receiver operating characteristic (ROC) curve. +other 34204705 hsa-mir-574 COVID-19 5p as a modulator of TMPRSS2 are associated with male infertility. +other 34204705 hsa-mir-125b COVID-19 5p as a modulator of TMPRSS2 are associated with male infertility. +other 34204705 hsa-mir-125a Infertility, Male 5p as a modulator of TMPRSS2 are associated with male infertility. +other 34204705 hsa-mir-125b Infertility, Male 5p as a modulator of TMPRSS2 are associated with male infertility. +other 34204705 hsa-mir-125a COVID-19 5p as a modulator of TMPRSS2 are associated with male infertility. +other 34204705 hsa-mir-204 COVID-19 5p as a modulator of TMPRSS2 are associated with male infertility. +other 34204705 hsa-mir-936 COVID-19 5p as a modulator of TMPRSS2 are associated with male infertility. +other 34204705 hsa-mir-936 Infertility, Male 5p as a modulator of TMPRSS2 are associated with male infertility. +other 34204705 hsa-mir-204 Infertility, Male 5p as a modulator of TMPRSS2 are associated with male infertility. +other 34204705 hsa-mir-574 Infertility, Male 5p as a modulator of TMPRSS2 are associated with male infertility. +lncRNA target 34204617 hsa-mir-365 Squamous Cell Carcinoma of Head and Neck Moreover, the fastest growing oral cancers with the highest viability produced the most miR-365. +transcription factor target 34204585 hsa-mir-146a Giant Cell Arteritis Correlative analysis of miR-mRNA quantities demonstrated a highly interrelated expression network of deregulated miRs and mRNAs in temporal arteries and identified KLF4 as a candidate target gene of deregulated miR +other 34204585 hsa-mir-424 Giant Cell Arteritis MiR5p expression in TABs and the presence of facial or carotid arteritis on ultrasound were associated with vision disturbances in GCA patients. +transcription factor target 34204585 hsa-mir-21 Giant Cell Arteritis Correlative analysis of miR-mRNA quantities demonstrated a highly interrelated expression network of deregulated miRs and mRNAs in temporal arteries and identified KLF4 as a candidate target gene of deregulated miR +other 34204289 hsa-mir-765 Central Nervous System Neoplasms Receiver-operator curve analysis showed that miR-149, miR-214, miR-574, miR-595 and miR765 could distinguish between CNS tumors and normal brain tissue. +circulation_biomarker_diagnosis_up 34204158 hsa-mir-425 Breast Neoplasms 5p were significantly upregulated and miR-451 was significantly downregulated, in the plasma of BC patients as compared with healthy controls. +circulation_biomarker_diagnosis_up 34204158 hsa-mir-145 Breast Neoplasms 5p were significantly upregulated and miR-451 was significantly downregulated, in the plasma of BC patients as compared with healthy controls. +circulation_biomarker_diagnosis_ns 34204158 hsa-mir-21 Breast Neoplasms In this study, we investigated the expression of 12 microRNA (miR-21/miR-155/miR-23a/miR-130a/miR-145/miR5 and miR-182) in the plasma of 41 newly diagnosed Lebanese BC patients with early invasive ductal carcinoma as compared with 32 healthy controls. +circulation_biomarker_diagnosis_up 34204158 hsa-mir-130a Breast Neoplasms 5p were significantly upregulated and miR-451 was significantly downregulated, in the plasma of BC patients as compared with healthy controls. +circulation_biomarker_diagnosis_ns 34204158 hsa-mir-182 Breast Neoplasms In this study, we investigated the expression of 12 microRNA (miR-21/miR-155/miR-23a/miR-130a/miR-145/miR5 and miR-182) in the plasma of 41 newly diagnosed Lebanese BC patients with early invasive ductal carcinoma as compared with 32 healthy controls. +circulation_biomarker_diagnosis_ns 34204158 hsa-mir-23a Breast Neoplasms In this study, we investigated the expression of 12 microRNA (miR-21/miR-155/miR-23a/miR-130a/miR-145/miR5 and miR-182) in the plasma of 41 newly diagnosed Lebanese BC patients with early invasive ductal carcinoma as compared with 32 healthy controls. +circulation_biomarker_diagnosis_ns 34204158 hsa-mir-155 Breast Neoplasms In this study, we investigated the expression of 12 microRNA (miR-21/miR-155/miR-23a/miR-130a/miR-145/miR5 and miR-182) in the plasma of 41 newly diagnosed Lebanese BC patients with early invasive ductal carcinoma as compared with 32 healthy controls. +circulation_biomarker_diagnosis_up 34203979 hsa-mir-21 high grade glioma 3p in serum exosomes may be useful molecular biomarkers for complementing clinical evaluation of early tumor progression during post-surgical therapy in patients with HGG. +circulation_biomarker_diagnosis_ns 34203979 hsa-mir-124 high grade glioma We previously identified miR-21, miR-222 and miR3p purified from serum exosomes as molecular signature to help pre-operative clinical diagnosis and grading of gliomas. +circulation_biomarker_diagnosis_up 34203979 hsa-mir-222 high grade glioma 3p in serum exosomes may be useful molecular biomarkers for complementing clinical evaluation of early tumor progression during post-surgical therapy in patients with HGG. +target gene 34203557 hsa-mir-203 Pancreatic Neoplasms Inhibition of miR-222 by Oncolytic Adenovirus-Encoded miRNA Sponges Promotes Viral Oncolysis and Elicits Antitumor Effects in Pancreatic Cancer Models. +other 34203452 hsa-mir-26b Retinitis Chronic and transient HG-induced changes in miRNA (miR-26a-5p, miR-26b-5p, let-7d-5p, let-7e-5p, miR-365a-3p, miR-146a-5p) were mostly convergent to altered IL-6 transcription. +other 34203452 hsa-mir-26a Retinitis Chronic and transient HG-induced changes in miRNA (miR-26a-5p, miR-26b-5p, let-7d-5p, let-7e-5p, miR-365a-3p, miR-146a-5p) were mostly convergent to altered IL-6 transcription. +other 34203452 hsa-let-7d Retinitis Chronic and transient HG-induced changes in miRNA (miR-26a-5p, miR-26b-5p, let-7d-5p, let-7e-5p, miR-365a-3p, miR-146a-5p) were mostly convergent to altered IL-6 transcription. +other 34202571 hsa-mir-650 Non-alcoholic Fatty Liver Disease RESULTS: in-silico constructed network revealed six mRNAs (YAP1, FOXA2, AMOTL2, TEAD2, SMAD4 and NF2), two miRNAs (miR-650 and miR-1205), and two lncRNAs (RPARP-AS1 and SRD5A3-AS1) that play important roles as a co-regulatory network in NAFLD pathogenesis. +other 34202571 hsa-mir-1205 Non-alcoholic Fatty Liver Disease RESULTS: in-silico constructed network revealed six mRNAs (YAP1, FOXA2, AMOTL2, TEAD2, SMAD4 and NF2), two miRNAs (miR-650 and miR-1205), and two lncRNAs (RPARP-AS1 and SRD5A3-AS1) that play important roles as a co-regulatory network in NAFLD pathogenesis. +other 34202375 hsa-mir-24 Mucocutaneous Lymph Node Syndrome 3p significantly higher in KD patients, which may be a potential diagnostic biomarker for KD. +target gene 34201896 hsa-mir-29b-2 Breast Neoplasms miR-29b2 and miR-29c play a suppressive role in breast cancer progression. +target gene 34201896 hsa-mir-29 Breast Neoplasms miR-29b2 and miR-29c play a suppressive role in breast cancer progression. +target gene 34201896 hsa-mir-29c Breast Neoplasms miR-29b2 and miR-29c play a suppressive role in breast cancer progression. +transcription factor target 34201741 hsa-mir-208b Cardiomegaly In summary, miR-208b targets the mRNAs of proteins involved in the generation of cardiac excitation and propagation, as well as of proteins involved in RNA translocation (Ran) and cardiac hypertrophic response (Rock2). +lncRNA target 34201353 hsa-mir-1 Squamous Cell Carcinoma of Head and Neck Our functional assays showed that inhibition of miR +transcription factor target 34201109 hsa-mir-29c Glaucoma TGFbeta2 treatment downregulated the expression of multiple miRNAs, including miR-29c-3p, compared to controls in LC cells. LC cells transfected with miR-29c-3p mimics or inhibitors modulated collagen expression. +circulation_biomarker_diagnosis_ns 34200891 hsa-mir-373 Lymphoma, T-Cell, Peripheral 3p, CD44 and RDX was decreased in PTL patients' blood, and their expression were the lowest in PTL patients' blood with inflammation. +circulation_biomarker_diagnosis_ns 34200463 hsa-mir-99a Breast Neoplasms Herein, we assessed the potential of a microRNA signature based on miR-30b-5p and miR-99a-5p levels in plasma as a diagnostic biomarker for breast cancer. +circulation_biomarker_diagnosis_up 34200314 hsa-mir-101 Colorectal Neoplasms Serum PVT1, MALAT1, miRNA-186 and miRNA-101 are novel non-invasive diagnostic biomarkers that could improve the clinical outcome of CRC. +circulation_biomarker_diagnosis_up 34200314 hsa-mir-186 Colorectal Neoplasms Serum PVT1, MALAT1, miRNA-186 and miRNA-101 are novel non-invasive diagnostic biomarkers that could improve the clinical outcome of CRC. +transcription factor target 34200161 hsa-mir-124 Amyotrophic Lateral Sclerosis We propose miR-124 as a new therapeutic target and a promising ALS biomarker in patient sub-populations. +genetics_GWAS 34200157 hsa-mir-608 Abortion, Habitual The purpose of this study was to investigate whether polymorphisms in five microRNAs (miRNAs), miR-604A>G, miR-608C>G, 631I/D, miR-938G>A, and miR3C>T, are associated with the risk of idiopathic recurrent pregnancy loss (RPL). +genetics_GWAS 34200157 hsa-mir-604 Abortion, Habitual These results reveal a significant association between the miR-604A>G and miR-938G>A polymorphisms and idiopathic RPL and suggest that miRNAs can affect RPL in Korean women. +genetics_GWAS 34200157 hsa-mir-1302 Abortion, Habitual The purpose of this study was to investigate whether polymorphisms in five microRNAs (miRNAs), miR-604A>G, miR-608C>G, 631I/D, miR-938G>A, and miR3C>T, are associated with the risk of idiopathic recurrent pregnancy loss (RPL). +genetics_GWAS 34200157 hsa-mir-938 Abortion, Habitual These results reveal a significant association between the miR-604A>G and miR-938G>A polymorphisms and idiopathic RPL and suggest that miRNAs can affect RPL in Korean women. +lncRNA target 34199886 hsa-mir-29 Cholangiocarcinoma 3p-family act as tumor-suppressors in ICC cells. +lncRNA target 34199886 hsa-mir-29a Cholangiocarcinoma 3p-family act as tumor-suppressors in ICC cells. +other 34199867 hsa-mir-181a Thyroid Cancer, Papillary This study shows for the first time that miR-181a-5p directly regulates SLC5A5 expression in the context of PTC and may decrease efficacy of radioiodine treatment. +other 34199767 hsa-mir-146a Coronary Artery Disease Conclusions: miR-146a expression levels were negatively correlated with TNF-alpha levels in patients with SCAD, irrespective of other metabolic or inflammatory markers, and with the severity of coronary artery disease. The results add to the knowledge on the role of miR-146a in TNF-alpha-based inflammation in SCAD and support future research on the potential therapeutic use of miR-146a in such a clinical scenario. +other 34199767 hsa-mir-146 Coronary Artery Disease Conclusions: miR-146a expression levels were negatively correlated with TNF-alpha levels in patients with SCAD, irrespective of other metabolic or inflammatory markers, and with the severity of coronary artery disease. The results add to the knowledge on the role of miR-146a in TNF-alpha-based inflammation in SCAD and support future research on the potential therapeutic use of miR-146a in such a clinical scenario. +exosome 34199766 hsa-mir-486 Urinary Bladder Neoplasms This is the first study to investigate EV-containing miRNA sequencing in pre- and postsurgery BC patient samples and our findings suggest that urinary EV-contained miR-451a and miR5p may be potential biomarkers for recurrence-free survival of BC patients with stage T1 disease. +exosome 34199766 hsa-mir-451a Urinary Bladder Neoplasms This is the first study to investigate EV-containing miRNA sequencing in pre- and postsurgery BC patient samples and our findings suggest that urinary EV-contained miR-451a and miR5p may be potential biomarkers for recurrence-free survival of BC patients with stage T1 disease. +other 34199723 hsa-mir-223 Myocardial Infarction 3p are promising independent predictors of thrombotic events and can be used for ischemic risk stratification after AMI. +other 34199723 hsa-mir-126 Myocardial Infarction 3p are promising independent predictors of thrombotic events and can be used for ischemic risk stratification after AMI. +circulation_biomarker_diagnosis_ns 34199703 hsa-mir-200a Endometritis We aimed (I) to investigate expression profile of eca-miR-155, eca-miR-223, eca-miR-17, eca-miR-200a, and eca-miR-205 (II) and to measure concentrations of interleukin 6 (IL-6), and prostaglandins (PGF(2alpha) and PGE(2)) in serum of mares with healthy and abnormal uterine status (endometritis). +circulation_biomarker_diagnosis_ns 34199703 hsa-mir-205 Endometritis We aimed (I) to investigate expression profile of eca-miR-155, eca-miR-223, eca-miR-17, eca-miR-200a, and eca-miR-205 (II) and to measure concentrations of interleukin 6 (IL-6), and prostaglandins (PGF(2alpha) and PGE(2)) in serum of mares with healthy and abnormal uterine status (endometritis). +other 34199580 hsa-mir-378a Carcinoma, Hepatocellular circGPC3 was further shown to act as a sponge of miR-378a-3p to regulate APSM (Abnormal spindle-like microcephaly associated) expression and modulate cell transformation. +other 34198846 hsa-mir-93 Prostatic Neoplasms 5p miRNAs are suggested to be potential biomarkers for PC risk stratification that could be included in non-invasive strategies such as liquid biopsy in precision medicine for PC management. +lncRNA target 34198800 hsa-mir-941 Severe Acute Respiratory Syndrome Available information indicates that two of these microRNAs, namely, hsa-miR-3941 and hsa-miR5p, combine effective targeting of SARS-CoV-2 genome with complementary antiviral or protective effects in the host cells that make them potential candidates for therapeutic treatment of most, if not all, COVID-19 variants known to date. +lncRNA target 34198800 hsa-mir-941 COVID-19 Available information indicates that two of these microRNAs, namely, hsa-miR-3941 and hsa-miR5p, combine effective targeting of SARS-CoV-2 genome with complementary antiviral or protective effects in the host cells that make them potential candidates for therapeutic treatment of most, if not all, COVID-19 variants known to date. +lncRNA target 34198800 hsa-mir-138 Severe Acute Respiratory Syndrome 5p, combine effective targeting of SARS-CoV-2 genome with complementary antiviral or protective effects in the host cells that make them potential candidates for therapeutic treatment of most, if not all, COVID-19 variants known to date. +lncRNA target 34198800 hsa-mir-138 COVID-19 Available information indicates that two of these microRNAs, namely, hsa-miR-3941 and hsa-miR5p, combine effective targeting of SARS-CoV-2 genome with complementary antiviral or protective effects in the host cells that make them potential candidates for therapeutic treatment of most, if not all, COVID-19 variants known to date. +lncRNA target 34198460 hsa-mir-34a Atrial Fibrillation Ulteriorly, the microRNA-transcription factor-mRNA network revealed that microRNA-34a-5p could target both RCAN1 and PPP3R1 in the pAF pathogenesis. In conclusion, our present study revealed several novel pAF-associated genes, miRNAs, and pathways, including microRNA-34a-5p, which might target RCAN1 and PPP3R1 to regulate pAF through the calcineurin-NFAT signaling pathway. +other 34198264 hsa-let-7c Osteoarthritis 5p expression is a novel strategy for OA and RA. +other 34198264 hsa-mir-149 Arthritis, Rheumatoid 5p expression is a novel strategy for OA and RA. +other 34198264 hsa-mir-149 Osteoarthritis 5p expression is a novel strategy for OA and RA. +other 34198264 hsa-let-7c Arthritis, Rheumatoid 5p expression is a novel strategy for OA and RA. +circulation_biomarker_diagnosis_ns 34197940 hsa-mir-210 Lupus Erythematosus, Systemic 5p and lower expression of SP1 and HSCARG in peripheral blood mononuclear cells. +other 34197720 hsa-mir-20a Diabetic Retinopathy SNHG16 and E2F1 were increased and miR-20a-5p was decreased in proliferative DR both in vivo and in vitro when compared with control or non-proliferative DR. This study indicated that SNHG16 regulated E2F1 expression by sponging miR-20a-5p and aggravating proliferative DR. +circRNA target 34197715 hsa-mir-153 Diabetic Nephropathies Circ-RBM4 alleviated the renal inflammation and renal fibrosis in DN by targeting the miR3p/NFIC axis. +lncRNA target 34197482 hsa-mir-210 Glioma 3p expression that affect malignant behaviors and chemoresistance via TGF-beta upregulation in glioma cells. +other 34197043 hsa-mir-25 Fibrosis, Renal These findings suggested that miR-25 cluster played an important role in the progression of IgAN, which provided new insights into the pathogenesis and treatment of IgAN. +circRNA target 34197029 hsa-mir-515 Leukemia, Myeloid, Acute In conclusion, circTASP1 acts as a sponge for miR5p to regulate HMGA2, thereby promoting proliferation and inhibiting apoptosis during AML progression. +other 34197004 hsa-mir-100 Arthritis The findings highlight the importance of miR5p/NOX4 axis in primary articular chondrocytes injury and provide new insights into therapeutic strategies for articular chondrocytes injury and osteoarthritis. +other 34197004 hsa-mir-100 Osteoarthritis The findings highlight the importance of miR5p/NOX4 axis in primary articular chondrocytes injury and provide new insights into therapeutic strategies for articular chondrocytes injury and osteoarthritis. +other 34196940 hsa-mir-137 Nasopharyngeal Carcinoma The aforementioned findings suggested that the miR-137/ERRalpha-mediated metabolic programming could be involved in the chemoresistance of NPC cells. +genetics_overexpression_promote 34196584 hsa-mir-665 Urinary Bladder Neoplasms MiR-665 overexpression significantly downregulated the expression of SMAD3, phospho-SMAD3, and SNAIL, reversed epithelial-mesenchymal transition progression, and inhibited the migration of bladder cancer cells. +lncRNA target 34196215 hsa-mir-206 Carcinoma, Hepatocellular inhibitor rescue experiments were performed to examine the role of the Linc1749808/miR-206 axis in HCC cells. +circulation_biomarker_diagnosis_up 34196150 hsa-mir-1 Laryngeal Neoplasms 3p (rs=0.443, p=0.039) and miR-196a-5p (rs=0.548; p=0.008) between plasma and adjacent tumour tissue LSCC samples. +circulation_biomarker_diagnosis_ns 34196150 hsa-mir-424 Laryngeal Neoplasms 5p in plasma and tissue samples from patients with advanced laryngeal squamous cell carcinoma (LSCC) and healthy controls. +circulation_biomarker_diagnosis_up 34196150 hsa-mir-196a Laryngeal Neoplasms 3p (rs=0.443, p=0.039) and miR-196a-5p (rs=0.548; p=0.008) between plasma and adjacent tumour tissue LSCC samples. +circulation_biomarker_diagnosis_ns 34196150 hsa-mir-210 Laryngeal Neoplasms 5p in plasma and tissue samples from patients with advanced laryngeal squamous cell carcinoma (LSCC) and healthy controls. +other 34195933 hsa-mir-125a Bicuspid Aortic Valve Disease The results suggested that miR-34a and miR-125a might be implicated in wall shear stress induced aortic pathogenesis due to their apparent regulatory roles in metalloproteinase 2 expression and extracellular matrix remodeling, which are key events in the weakening of aortic walls among BA patients. +other 34195933 hsa-mir-34a Bicuspid Aortic Valve Disease The results suggested that miR-34a and miR-125a might be implicated in wall shear stress induced aortic pathogenesis due to their apparent regulatory roles in metalloproteinase 2 expression and extracellular matrix remodeling, which are key events in the weakening of aortic walls among BA patients. +other 34195885 hsa-mir-146a Sick Sinus Syndrome The highest risk of SSS was conferred by the combination SCN10A rs6795970*T+FNDC3B rs9647379*C+MIR146A rs2910164*C+SYT10 rs7980799*C+KCNE1 rs1805127*G (OR 2.98, CI 1.77-5.00, P = 1.27 x 10(-5), P(FDR) = 0.022). +genetics_overexpression_suppress 34195851 hsa-mir-138 Carcinoma, Squamous Cell, Cutaneous Cell lines with a high and low HCP5 expression were screened, and a pcDNA3.1HCP5 overexpression vector, small interfering RNA against HCP5, miR1385p mimics and miR1385p inhibitors were transfected into the CSCC cells. +circulation_biomarker_prognosis_down 34195390 hsa-mir-148a Breast Neoplasms Conclusion miRNA-148a and miRNA-30c expressions were down regulated in female patients with breast cancer and might be considered as potential blood biomarkers. +other 34195365 hsa-mir-761 Thyroid Neoplasms Long non-coding RNA HOTAIR/microRNA-761 sponge regulates PPME1 and further influences cell biological functions in thyroid carcinoma. +genetics_overexpression_promote 34195294 hsa-mir-504 Stomach Neoplasms Additionally, miR-504 overexpression increased the viability of gastric cancer cells. +exosome 34195287 hsa-mir-208b Myocardial Infarction This study was aimed at investigating the effects of myocardial infarction- (MI-) associated extracellular vesicle- (EV-) delivered miR-208b on human umbilical vein endothelial cells (HUVECs). +lncRNA target 34195280 hsa-mir-125a Dehydration Further experiments showed that oxidative stress and miR-125a-5p together suppressed the expression of VEGF during osteogenic differentiation of hADSCs and that the inhibition of miR-125a-5p reversed the effect of oxidative stress. +exosome 34195198 hsa-mir-770 Carcinoma, Non-Small-Cell Lung Tumor Cell-Derived Exosomal miR-770 Inhibits M2 Macrophage Polarization via Targeting MAP3K1 to Inhibit the Invasion of Non-small Cell Lung Cancer Cells. +target gene 34195187 hsa-mir-197 Prostatic Neoplasms MiR-197 Inhibitor Loaded AbCD133@MSNs@GNR Affects the Development of Prostate Cancer Through Targeting ITGAV. +lncRNA target 34194562 hsa-mir-1539 Intervertebral disc disease Collectively, the present results suggested that lower RP11-81H3.2 expression levels were associated with higher-grade IDD, and that RP11-81H3.2 inhibited NP cell apoptosis by decreasing the levels of miR-1539 to increase COL2A1 expression levels. +lncRNA target 34194560 hsa-mir-155 Sjogren's Syndrome 5p may serve to be a potential target for the treatment of SS. +target gene 34194557 hsa-mir-26b Ovarian Neoplasms Interference of long non-coding RNA HAGLROS inhibits the proliferation and promotes the apoptosis of ovarian cancer cells by targeting miR-26b-5p. +genetics_knock down_suppress 34194552 hsa-mir-485 Inflammation Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to detect the expression of lncRNA NORAD, microRNA-485 (miR-485) and nuclear respiratory factor 1 (NRF1) in the tissues of patients with DN and high-glucose (HG)-induced human mesangial cells (HMCs). NORAD knockdown inhibited HG-induced HMC proliferation, inflammation and fibrosis by regulating miR-485/NRF1, providing a possible therapeutic strategy for DN. +genetics_knock down_suppress 34194552 hsa-mir-485 Diabetic Nephropathies Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to detect the expression of lncRNA NORAD, microRNA-485 (miR-485) and nuclear respiratory factor 1 (NRF1) in the tissues of patients with DN and high-glucose (HG)-induced human mesangial cells (HMCs). NORAD knockdown inhibited HG-induced HMC proliferation, inflammation and fibrosis by regulating miR-485/NRF1, providing a possible therapeutic strategy for DN. +circulation_biomarker_diagnosis_ns 34194551 hsa-mir-20a Heart Failure Collectively, the results of the present study demonstrated that miR-320a promoted myocardial fibroblast proliferation via regulating the PIK3CA/Akt/mTOR signaling pathway in HEH2 cells, suggesting that serum exosomal miR-320a may serve as a potential biomarker for the diagnosis of CHF. +other 34194546 hsa-mir-29b Vitreoretinopathy, Proliferative The expression levels of miR-29b were positively correlated with E-cadherin mRNA expression, while an inverse correlation was observed between miR-29b and alpha-SMA mRNA expression in epiretinal membranes of patients with PVR. +lncRNA target 34194502 hsa-mir-18a Esophageal Neoplasms MATERIALS AND METHODS: RT-qPCR assay was applied to measure the expression of WDFY3-AS2 and miR-18a in EC samples and cells. CONCLUSIONS: WDFY3-AS2 modulates the expressional level of PTEN as a competitive endogenous RNA via sponging miR-18a in EC, which suggests that the WDFY3-AS2/miR-18a/PTEN pathway might be involved in the progression of EC. +circulation_biomarker_diagnosis_ns 34194500 hsa-mir-122 Carcinoma, Hepatocellular The aim of the study was to explore the association of serum miR-122 with response to sorafenib in hepatitis B virus- (HBV-) related hepatocellular carcinoma (HCC) patients and to further reveal the effect of the virus load on such potential relationship. CONCLUSION: Higher serum level of miR-122 at baseline was associated with a better response to sorafenib in HBV-related locally advanced HCC patients, and relatively high HBV load weakened such predictive effect mentioned above. +lncRNA target 34194499 hsa-mir-577 Carcinoma, Hepatocellular CXCL5 was a target gene of miR-577, and its expression was mediated by miR-577 in HCC. The newly identified role of the CXCL5/miR-577/NF-kappaB axis provides novel insights into the targeted therapy of HCC. +other 34194498 hsa-mir-6715 Colorectal Neoplasms RESULTS: The expression of CST4 in CRC tissues was significantly higher than that in normal paracancerous tissues, but the results for miRNA5p were opposite. +other 34194495 hsa-mir-375 Carcinoma, Non-Small-Cell Lung These data suggest that chidamide shows a synergistic effect with radiation therapy on lung squamous cell carcinomas by modulating the miREIF4G3 axis, which may afford an effective strategy to overcome the drug resistance of chidamide in clinical cancer therapy. +other 34193814 hsa-mir-95 Diabetic Nephropathies 3p and miR-631 could reflect the severity and prognosis of DN. +other 34193814 hsa-mir-631 Diabetic Nephropathies 3p and miR-631 could reflect the severity and prognosis of DN. +other 34193814 hsa-mir-185 Diabetic Nephropathies 5p, miR-1246, and miR-631 could serve as simple and noninvasive tools to distinguish patients with DM, DN, DM with IgAN, and DM with MN. +genetics_GWAS 34193555 hsa-mir-183 Nonsyndromic sensorineural hearing loss A point mutation in miR-96 causes non-syndromic progressive peripheral hearing loss and alters structure and physiology of the central auditory system. +genetics_GWAS 34193555 hsa-mir-183 Hearing Loss Moreover, the different phenotypic outcomes of different types of mutations in the Mir-183 cluster corroborate the requirement of mutation-tailored therapies in patients with hearing loss. +genetics_GWAS 34193555 hsa-mir-96 Hearing Loss A point mutation in miR-96 causes non-syndromic progressive peripheral hearing loss and alters structure and physiology of the central auditory system. +genetics_GWAS 34193555 hsa-mir-96 Nonsyndromic sensorineural hearing loss A point mutation in miR-96 causes non-syndromic progressive peripheral hearing loss and alters structure and physiology of the central auditory system. +genetics_knock down_suppress 34193422 hsa-mir-200c Diabetes, Gestational Premature senescence and NTDs were abolished by knockout of the transcription factor Foxo3a, the miR-200c gene, and the cell cycle inhibitors p21 and p27; transgenic expression of the dominant-negative FoxO3a mutant; or the senomorphic rapamycin. +genetics_knock down_suppress 34193422 hsa-mir-200c Neural Tube Defects Premature senescence and NTDs were abolished by knockout of the transcription factor Foxo3a, the miR-200c gene, and the cell cycle inhibitors p21 and p27; transgenic expression of the dominant-negative FoxO3a mutant; or the senomorphic rapamycin. +lncRNA target 34193130 hsa-mir-636 Endometrial Neoplasms CONCLUSIONS: In conclusion, this study showed that MONC inhibits the malignant phenotypes of ECSCs and ECCs by regulating the miR-636/GLCE axis. +lncRNA target 34193130 hsa-mir-636 Carcinoma, Endometrioid CONCLUSIONS: In conclusion, this study showed that MONC inhibits the malignant phenotypes of ECSCs and ECCs by regulating the miR-636/GLCE axis. +other 34193018 hsa-mir-150 Carcinoma, Non-Small-Cell Lung 3p, is an oncogenic factor in NSCLC progression. +other 34193018 hsa-mir-186 Carcinoma, Non-Small-Cell Lung 3p, is an oncogenic factor in NSCLC progression. +genetics_GWAS 34192880 hsa-mir-18a Prostatic Neoplasms Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR +genetics_GWAS 34192880 hsa-mir-100 Prostatic Neoplasms Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR +genetics_GWAS 34192880 hsa-mir-145 Prostatic Neoplasms Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR +genetics_GWAS 34192880 hsa-let-7 Prostatic Neoplasms Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR +genetics_GWAS 34192880 hsa-mir-24 Prostatic Neoplasms Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR +genetics_GWAS 34192880 hsa-mir-99a Prostatic Neoplasms Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR +genetics_GWAS 34192880 hsa-let-7a Prostatic Neoplasms Nevertheless, after 5 days of irradiation, about 15% of the initial number of prostate tumor cells retained their viability, which is due to their special genetic and epigenetic characteristics: increased copy number and expression of genes BRCA2, CDK1, CDKN1B, H2AX, RAD50, XRCC4, RBBP8 and EP300 and reduced copy number and expression of CCND3, TP53, and BCL2 genes, as well as differential expression of six microRNAs (hsa-miR-18a-5p, hsa-miR +lncRNA target 34192708 hsa-mir-155 Carcinoma, Renal Cell 5p may promote cell growth of ccRCC via inhibiting PEG3 expression. +lncRNA target 34192661 hsa-mir-222 Osteoarthritis CONCLUSION: HOTAIR might contribute to IL-1beta-induced chondrocytes death, inflammation, extracellular matrix degradation, and oxidative stress in OA via miR3p/ADAM10 axis. +other 34191854 hsa-mir-196a Prostatic Neoplasms, Castration-Resistant In conclusion, this study provides the rational for a role of miR-196a in the beta2-adrenergic receptor mediated neuroendocrine differentiation of LNCaP prostate cancer cells. +genetics_overexpression_promote 34191748 hsa-mir-494 Osteosarcoma After circ_0081001 was overexpressed, the proliferation, migration, and invasion of OS cells were boosted but the apoptosis was reduced, whereas miR +lncRNA target 34191497 hsa-mir-21 Esophageal Squamous Cell Carcinoma In particular, MI-Anti-miRNAs that targeted miRNA-21, which is involved in tumor initiation, progression, invasion, and metastasis in several types of cancer, successfully repressed miRNA-21 activity, resulting in a superior antitumor activity in both solid and metastatic tumor models without causing systemic toxicity. +genetics_knock down_promote 34191363 hsa-mir-1 Prostatic Neoplasms In addition, miR-1 overexpression suppressed PCa cell progression by repressing MAP 3 K1. +genetics_overexpression_promote 34191246 hsa-mir-122 Uterine Cervical Neoplasms Importantly, overexpression of RAD21 restored the roles of miR-122 in CC. +lncRNA target 34191053 hsa-mir-210 Lymphohistiocytosis, Hemophagocytic Taken together, our results indicated that lncRNA-MEG3 participated in the inflammatory responses and apoptosis in HPS-infected PAMs through modulating the miR-210/TLR4 axis. +genetics_overexpression_suppress 34191006 hsa-mir-335 Leukemia, Myeloid, Acute 3p overexpression significantly inhibited cell proliferation and induced cell cycle G0/G1 arrest and apoptosis in AML cell lines (THP-1 and U937). +other 34190510 hsa-mir-99b Carcinoma, Renal Cell CONCLUSIONS: Levels of miR-99b, -210 and -377 expression in RCC tumor tissue might be used as a basis for future predictive panel intended for the assessment of the sensitivity to the regimens of neoadjuvant RCC treatment. +target gene 34190442 hsa-mir-155 Breast Neoplasms Long Non-Coding RNA NORAD Inhibits Breast Cancer Cell Proliferation and Metastasis by Regulating miR-155-5p/SOCS1 Axis. +other 34190406 hsa-mir-27a Intervertebral Disc Degeneration The results showed that miR27a was rarely expressed in healthy intervertebral discs but showed increased expression in degenerated intervertebral discs. +lncRNA target 34190001 hsa-mir-139 Esophageal Squamous Cell Carcinoma 5p to upregulate PDE4A via the competing endogenous RNA network in ESCC cells. +genetics_overexpression_suppress 34189997 hsa-mir-491 Carcinoma, Non-Small-Cell Lung 5p downregulation or MAP3K3 overexpression reversed the effect of circ_0006988 silencing on NSCLC cell progression. +other 34189972 hsa-mir-27 Heart Failure While betalain pre-treated rats prevented the cardiac failure significantly (p < 0.01) with improved anti-oxidant enzymes, abrogated the inflammatory signals with restored matrix proteins, cardiac biomarker genes, and attenuated miR-423 and miR-27 compared to heart failure rats. +other 34189972 hsa-mir-423 Heart Failure While betalain pre-treated rats prevented the cardiac failure significantly (p < 0.01) with improved anti-oxidant enzymes, abrogated the inflammatory signals with restored matrix proteins, cardiac biomarker genes, and attenuated miR-423 and miR-27 compared to heart failure rats. +circulation_biomarker_prognosis_ns 34189151 hsa-mir-24-2 Carcinoma, Hepatocellular Additionally, high-serum miR2p in HBV-related HCC patients was associated with cirrhosis, tumor size, clinical stage, and poor overall survival prognosis. +circulation_biomarker_prognosis_ns 34189151 hsa-mir-24 Carcinoma, Hepatocellular CONCLUSIONS: High-serum miR +transcription factor target 34188710 hsa-mir-744 Glioblastoma 5p targets RFC2 and suppresses the progression of GBM by repressing cellular proliferation, migration and Bcl-2 protein expression, and effectively promoting caspase-3 activity and Bax protein expression. +circulation_biomarker_prognosis_ns 34188709 hsa-mir-433 Carcinoma, Non-Small-Cell Lung To explore the impact of exosomal miR-433 in non-small cell lung cancer (NSCLC) and understand its mechanism of action in NSCLC progression, the present study isolated the exosomes from the plasma of patients with NSCLC after chemotherapy and found that miR-433 expression was lower in plasma of patients with resistant NSCLC compared with in plasma of patients with sensitive NSCLC and in normal serum. +other 34188706 hsa-mir-32 Carcinoma, Hepatocellular Therefore, MT1JP may upregulate PTEN by downregulating miR-32 to regulate HCC cell proliferation. +genetics_overexpression_promote 34188550 hsa-mir-375 Uterine Cervical Neoplasms Overexpression of SNHG17 in CC promoted the progression of CC partly via targeting miR +target gene 34188473 hsa-mir-338 Neuroblastoma LINC00839 Regulates Proliferation, Migration, Invasion, Apoptosis and Glycolysis in Neuroblastoma Cells Through miR-338-3p/GLUT1 Axis. +genetics_knock down_promote 34188461 hsa-mir-144 Hyperglycemia MALAT1 functioned as competing endogenous RNA (ceRNA) for miR-144, and pre-treatment with MALAT1 siRNA decreased mTOR activity and p-tau protein level in HG-treated hippocampal cells, which was significantly attenuated by miR-144 mimics. Moreover, miR-144 negatively regulated the expression of mTOR and knockdown of MALAT1 suppressed mTOR, while overexpression of mTOR abrogated protective effects of MALAT1 knockdown in HG-treated hippocampal cells. +genetics_overexpression_promote 34187598 hsa-mir-18a Carcinoma, Hepatocellular In HCC cells, circRHOBTB3 overexpression decreased mature miR-18a level but not miR-18a precursor. +genetics_overexpression_promote 34187569 hsa-mir-1291 Leukemia, Myeloid, Acute Overexpression of PIK3R5 enhanced the promoting effect of HCP5 in the development of AML, while weakened the suppression of miR-1291 to AML progression. +lncRNA target 34187521 hsa-mir-10a Leukemia-Lymphoma, Adult T-Cell RESULTS: High-throughput in silico analysis revealed 9 DEMs hsa-let-7a, hsa-let-7g, hsa-mir-181b, hsa-mir-26b, hsa-mir-30c, hsa-mir-186, hsa-mir-10a, hsa-mir-30b, and hsa-let-7f between ATLL patients and healthy donors. +lncRNA target 34187521 hsa-let-7f Lymphoma RESULTS: High-throughput in silico analysis revealed 9 DEMs hsa-let-7a, hsa-let-7g, hsa-mir-181b, hsa-mir-26b, hsa-mir-30c, hsa-mir-186, hsa-mir-10a, hsa-mir-30b, and hsa-let-7f between ATLL patients and healthy donors. +lncRNA target 34187521 hsa-let-7f Leukemia-Lymphoma, Adult T-Cell RESULTS: High-throughput in silico analysis revealed 9 DEMs hsa-let-7a, hsa-let-7g, hsa-mir-181b, hsa-mir-26b, hsa-mir-30c, hsa-mir-186, hsa-mir-10a, hsa-mir-30b, and hsa-let-7f between ATLL patients and healthy donors. +lncRNA target 34187521 hsa-mir-181b Lymphoma RESULTS: High-throughput in silico analysis revealed 9 DEMs hsa-let-7a, hsa-let-7g, hsa-mir-181b, hsa-mir-26b, hsa-mir-30c, hsa-mir-186, hsa-mir-10a, hsa-mir-30b, and hsa-let-7f between ATLL patients and healthy donors. +lncRNA target 34187521 hsa-let-7a Leukemia-Lymphoma, Adult T-Cell RESULTS: High-throughput in silico analysis revealed 9 DEMs hsa-let-7a, hsa-let-7g, hsa-mir-181b, hsa-mir-26b, hsa-mir-30c, hsa-mir-186, hsa-mir-10a, hsa-mir-30b, and hsa-let-7f between ATLL patients and healthy donors. +lncRNA target 34187521 hsa-let-7a Lymphoma RESULTS: High-throughput in silico analysis revealed 9 DEMs hsa-let-7a, hsa-let-7g, hsa-mir-181b, hsa-mir-26b, hsa-mir-30c, hsa-mir-186, hsa-mir-10a, hsa-mir-30b, and hsa-let-7f between ATLL patients and healthy donors. +lncRNA target 34187521 hsa-let-7g Lymphoma RESULTS: High-throughput in silico analysis revealed 9 DEMs hsa-let-7a, hsa-let-7g, hsa-mir-181b, hsa-mir-26b, hsa-mir-30c, hsa-mir-186, hsa-mir-10a, hsa-mir-30b, and hsa-let-7f between ATLL patients and healthy donors. +lncRNA target 34187521 hsa-mir-186 Lymphoma RESULTS: High-throughput in silico analysis revealed 9 DEMs hsa-let-7a, hsa-let-7g, hsa-mir-181b, hsa-mir-26b, hsa-mir-30c, hsa-mir-186, hsa-mir-10a, hsa-mir-30b, and hsa-let-7f between ATLL patients and healthy donors. +lncRNA target 34187521 hsa-let-7g Leukemia-Lymphoma, Adult T-Cell RESULTS: High-throughput in silico analysis revealed 9 DEMs hsa-let-7a, hsa-let-7g, hsa-mir-181b, hsa-mir-26b, hsa-mir-30c, hsa-mir-186, hsa-mir-10a, hsa-mir-30b, and hsa-let-7f between ATLL patients and healthy donors. +lncRNA target 34187521 hsa-mir-186 Leukemia-Lymphoma, Adult T-Cell RESULTS: High-throughput in silico analysis revealed 9 DEMs hsa-let-7a, hsa-let-7g, hsa-mir-181b, hsa-mir-26b, hsa-mir-30c, hsa-mir-186, hsa-mir-10a, hsa-mir-30b, and hsa-let-7f between ATLL patients and healthy donors. +lncRNA target 34187521 hsa-mir-10a Lymphoma RESULTS: High-throughput in silico analysis revealed 9 DEMs hsa-let-7a, hsa-let-7g, hsa-mir-181b, hsa-mir-26b, hsa-mir-30c, hsa-mir-186, hsa-mir-10a, hsa-mir-30b, and hsa-let-7f between ATLL patients and healthy donors. +lncRNA target 34187521 hsa-mir-181b Leukemia-Lymphoma, Adult T-Cell RESULTS: High-throughput in silico analysis revealed 9 DEMs hsa-let-7a, hsa-let-7g, hsa-mir-181b, hsa-mir-26b, hsa-mir-30c, hsa-mir-186, hsa-mir-10a, hsa-mir-30b, and hsa-let-7f between ATLL patients and healthy donors. +lncRNA target 34187513 hsa-mir-2911 Esophageal Squamous Cell Carcinoma CONCLUSION: Taken together, honeysuckle-derived miR2911 showed an anti-tumor effect in colon cancer through targeting TGF-beta1 mRNA. +circulation_biomarker_diagnosis_ns 34187448 hsa-mir-93 Inflammation 5p was declined in DN serum samples and HG-treated HGMCs. +circulation_biomarker_diagnosis_ns 34187448 hsa-mir-93 Diabetic Nephropathies 5p was declined in DN serum samples and HG-treated HGMCs. +genetics_overexpression_suppress 34187411 hsa-mir-210 Squamous Cell Carcinoma of Head and Neck BTG2 (anti-proliferation factor 2) was identified as the target gene of miR-210, and BTG2 overexpression inhibited the proliferation and invasion of LSCC cells. CONCLUSION: The results of this study suggest that TINCR inhibits the proliferation and invasion of LSCC by regulating the miR-210/BTG2 pathway, participates in cell cycle regulation, and may become a target for the treatment of LSCC. +lncRNA target 34187303 hsa-mir-9 Osteoarthritis In conclusion, our findings illuminated that inhibition of MIR22HG ameliorated IL-1beta-induced apoptosis and ECM degradation of human chondrocytes through miR3p/ADAMTS5 pathway, which may provide a potentially promising target for OA treatment. +other 34187214 hsa-mir-498 Endometrial Neoplasms In this study, we investigated the mechanisms of lncRNA HOXB cluster antisense RNA 3 (HOXB-AS3), miRNA(miR)5p, and disintegrin and metalloproteinase domain-containing protein 9 (ADAM9) in endometrial carcinoma (EC) cells. +other 34186489 hsa-mir-636 Pulmonary Arterial Hypertension Two microRNAs (miR-636 and miR5p) were selected by all methods and used to predict PAH diagnosis with high accuracy. +other 34186489 hsa-mir-187 Pulmonary Arterial Hypertension Two microRNAs (miR-636 and miR5p) were selected by all methods and used to predict PAH diagnosis with high accuracy. +lncRNA target 34186326 hsa-mir-145 Breast Neoplasms 5p targeting SOX2 was identified as a potential predictive biomarker for breast cancer stemness. +other 34186058 hsa-let-7c Melanoma Our study demonstrates an MITF-governed biogenesis mechanism that results in differential expression of clustered 99a/let-7c/125b-2 miRNAs that control melanoma progression. +circulation_biomarker_diagnosis_up 34185461 hsa-mir-27a Breast Neoplasms Our results exhibited significantly higher expression level of plasma miR-27a in breast cancer patients (median= 8.3 and 19 fold change for early and late stages respectively) compared to controls, high risk group and benign group with (P <0.001) for each. +other 34185416 hsa-mir-146b Airway Inflammation In the current study, we aimed to explore whether miR-146a/b could regulate cellular responses to RVs in HBECs and airways during RV-induced asthma exacerbation. +other 34185416 hsa-mir-146b Respirovirus Infections In the current study, we aimed to explore whether miR-146a/b could regulate cellular responses to RVs in HBECs and airways during RV-induced asthma exacerbation. +lncRNA target 34185281 hsa-mir-32 Myocardial Infarction 3p regulates myocardial injury induced by micro-embolism and micro-vascular obstruction by targeting RNF13 to regulate the stability of atherosclerotic plaques. +lncRNA target 34185281 hsa-mir-32 Plaque, Atherosclerotic 3p regulates myocardial injury induced by micro-embolism and micro-vascular obstruction by targeting RNF13 to regulate the stability of atherosclerotic plaques. +other 34185245 hsa-mir-17 Leukemia, Myeloid, Acute 5p and Beclin-1. +other 34185228 hsa-mir-199a Intracranial Aneurysm Expression of miR-125b-5p, miR3p and miR-199a-5p was significantly decreased in patients with poor prognosis and vasospasm. +other 34185228 hsa-mir-125b Intracranial Aneurysm Expression of miR-125b-5p, miR3p and miR-199a-5p was significantly decreased in patients with poor prognosis and vasospasm. +other 34185228 hsa-mir-143 Intracranial Aneurysm Expression of miR-125b-5p, miR3p and miR-199a-5p was significantly decreased in patients with poor prognosis and vasospasm. +genetics_overexpression_promote 34185205 hsa-mir-548g Esophageal Squamous Cell Carcinoma The overexpression of miR-548g also promoted ESCC cell migration and invasion. +lncRNA target 34184952 hsa-mir-760 Osteoporosis Our results demonstrated that LINC00963 positively regulated the expression of ETS1 by directly targeting miR-760, and then promoted osteogenic differentiation of hBMSCs in vitro, and also attenuated OP progression in vivo, suggesting that LINC00963 might be a potential therapeutic target for OP. +genetics_knock down_suppress 34184734 hsa-mir-8b Central Nervous System Diseases Knockdown miR-8b by anti-MIRs method caused severe defects of eyes and CNS. +lncRNA target 34184201 hsa-mir-222 Myocardial Reperfusion Injury MiR-222 silencing in AC16 cells simulated the phenotypes of MIRI patients and HR-treated cells, indicating that LSINCT5 functions via miR-222 to regulate proliferation and apoptosis of HR-treated AC16 cells. LncRNA LSINCT5 was upregulated during MI pathogenesis, and LSINCT5 regulated MIRI possibly via a potential LSINCT5/miR-222 axis and PI3K/AKT signaling pathway. +lncRNA target 34184135 hsa-mir-582 FG syndrome In conclusion, hsa_circ_0074371 downregulation inhibited proliferation, migration, and invasion of trophoblast cells via sponging miR +lncRNA target 34184082 hsa-mir-3074 Arthritis, Rheumatoid A total of four putative microRNAs (miRNAs or miRs), namely, hsamiR30745p, hsamiR3733p, hsamiR7663p and hsamiR34c5p, were screened to be sponged by circPTPN22 via bioinformatics analysis and then experimentally verified to be upregulated in RA PBMCs compared with controls. +lncRNA target 34184082 hsa-mir-34c Arthritis, Rheumatoid A total of four putative microRNAs (miRNAs or miRs), namely, hsamiR30745p, hsamiR3733p, hsamiR7663p and hsamiR34c5p, were screened to be sponged by circPTPN22 via bioinformatics analysis and then experimentally verified to be upregulated in RA PBMCs compared with controls. +lncRNA target 34184082 hsa-mir-373 Arthritis, Rheumatoid A total of four putative microRNAs (miRNAs or miRs), namely, hsamiR30745p, hsamiR3733p, hsamiR7663p and hsamiR34c5p, were screened to be sponged by circPTPN22 via bioinformatics analysis and then experimentally verified to be upregulated in RA PBMCs compared with controls. +lncRNA target 34184082 hsa-mir-766 Arthritis, Rheumatoid A total of four putative microRNAs (miRNAs or miRs), namely, hsamiR30745p, hsamiR3733p, hsamiR7663p and hsamiR34c5p, were screened to be sponged by circPTPN22 via bioinformatics analysis and then experimentally verified to be upregulated in RA PBMCs compared with controls. +circulation_biomarker_diagnosis_up 34184078 hsa-mir-106a Parkinson Disease The aim of the present study was to investigate the effects of an interval training program on a cycle ergometer on the expression levels of miR106a5p, miR103a3p and miR29a3p in serum samples from men with PD. The expression levels of miR106a5p, miR103a3p and miR29a3p in the experimental group were increased after physical exercise and were associated with cognitive improvement in men with PD. +circulation_biomarker_diagnosis_up 34184078 hsa-mir-29a Parkinson Disease The aim of the present study was to investigate the effects of an interval training program on a cycle ergometer on the expression levels of miR106a5p, miR103a3p and miR29a3p in serum samples from men with PD. The expression levels of miR106a5p, miR103a3p and miR29a3p in the experimental group were increased after physical exercise and were associated with cognitive improvement in men with PD. +circulation_biomarker_diagnosis_up 34184078 hsa-mir-103a Parkinson Disease The aim of the present study was to investigate the effects of an interval training program on a cycle ergometer on the expression levels of miR106a5p, miR103a3p and miR29a3p in serum samples from men with PD. The expression levels of miR106a5p, miR103a3p and miR29a3p in the experimental group were increased after physical exercise and were associated with cognitive improvement in men with PD. +circRNA target 34184075 hsa-mir-654 Carcinoma, Hepatocellular In conclusion, interference with circRNA DOCK1 inhibited proliferation, invasion and migration of HCC cells by regulating the miR6545p/SMAD2 axis. +lncRNA target 34183954 hsa-mir-125b Laryngeal Neoplasms Down regulation of lncRNA MALAT1 inhibits laryngocarcinoma proliferation and invasion by modulating miR-125b/HMGA1. CONCLUSION: LncRNA MALAT1 promotes the development of laryngocarcinoma by regulating the expression level of HMGA1 by acting as a miR-125b ceRNA and may be considered as a new strategy for the development of laryngocarcinoma. +circulation_biomarker_prognosis_ns 34183951 hsa-mir-497 Intracranial Arteriosclerosis miR-497 expression rises in ATCI patients, so this miR is expected to become a serum diagnostic marker for ATCI. +other 34183927 hsa-mir-451a Prostatic Neoplasms Conclusion miR-451a is lowly expressed in prostate cancer, and patients with low expression have a poor prognosis. +exosome 34183076 hsa-mir-622 Colorectal Neoplasms CONCLUSION: Hsa_circ_0000231 attenuated Sev-aroused repression impacts on CRC development by sponging miR-622. +transcription factor target 34183039 hsa-mir-195 Intervertebral Disc Degeneration CONCLUSION: MiR-195 was significantly upregulated in NP tissues of IVDD patients, and inhibition of miR-195 could protect human NP cells from TNF-alpha-induced apoptosis via upregulation of Bcl-2. +genetics_knock down_promote 34183035 hsa-mir-107 Osteoarthritis RESULTS: HOTAIR expression was enhanced, and miR-107 level was reduced in OA cartilage samples. CONCLUSION: HOTAIR knockdown promoted chondrocyte proliferation, but inhibited cell apoptosis and ECM degradation in OA chondrocytes by regulating the miR-107/CXCL12 axis. +circRNA target 34182990 hsa-mir-29b Stomach Neoplasms CONCLUSIONS: Elevated circRNA_100290 expression in GC promotes cell proliferation, invasion and EMT via the miR-29b-3p/ITGA11 axis and might be regulated by EIF4A3. +lncRNA target 34182945 hsa-mir-21 Triple Negative Breast Neoplasms CONCLUSION: Therefore, BRE-AS1 may inhibit TNBC by downregulating miR-21. +other 34182814 hsa-mir-615 Cholangiocarcinoma 5p/AMOT/YAP pathway, which may be a novel CCA pathway. +genetics_overexpression_promote 34182107 hsa-mir-8 Death Overexpression of miR-8 in the CA increased cell size of the gland and expression of Jhamt (a gene coding for a key regulatory enzyme in JH biosynthesis), resulting in pupal lethality. By contrast, sponge-mediated reduction of miR-8 in the CA decreased cell size and Jhamt expression, but did not cause lethality. +genetics_overexpression_promote 34182107 hsa-mir-8 Perinatal Death Overexpression of miR-8 in the CA increased cell size of the gland and expression of Jhamt (a gene coding for a key regulatory enzyme in JH biosynthesis), resulting in pupal lethality. +other 34182078 hsa-mir-132 Testicular Damage Hippo pathway, which is highly conservative and may be activated by miR132 and miR195a, can control organ size and tissue regeneration, and participate in injury and deformity. +other 34182078 hsa-mir-195a Testicular Damage Hippo pathway, which is highly conservative and may be activated by miR132 and miR195a, can control organ size and tissue regeneration, and participate in injury and deformity. +circulation_biomarker_diagnosis_ns 34181969 hsa-mir-486 Acute Kidney Injury 5p mimic increased its levels in proximal tubules and endothelial cells, and improved plasma creatinine, histological injury, neutrophil infiltration, and apoptosis. +other 34181894 hsa-mir-519c Inflammation Furthermore, human placentas from normal and inflammation-associated pregnancies demonstrated that a decreased placental microRNA-519c level was linked to infection-induced inflammatory pathologies during pregnancy. +other 34181894 hsa-mir-519c Premature Birth CONCLUSION: We identified microRNA-519c, a human placenta-specific microRNA, as a novel regulator of immune adaptation associated with infection-induced preterm birth at the maternal-fetal interface. Our study serves as a basis for future experiments to explore the potential use of microRNA-519c as a biomarker for infection-induced preterm birth. +lncRNA target 34181826 hsa-mir-198 Ovarian Neoplasms CONCLUSION: MiR-198 may possess an ability to inhibit activation of the P13K/Akt pathway, thus suppressing the OC cell proliferation, migration, as well as invasion. +circulation_biomarker_diagnosis_up 34181356 hsa-mir-148a Carcinoma, Non-Small-Cell Lung This study aimed to evaluate the role of serum miR-148a as a non-invasive biomarker in non-small cell lung cancer (NSCLC) patients and to assess the correlation between miR-148a and Bcl-2, as one of its target proteins. RESULTS: Significant lower expression of serum miR-148a and higher serum Bcl-2 levels were observed in NSCLC patients as compared to the control group (p. +other 34181233 hsa-mir-18a Myocardial Infarction Transfection of miR-18a-5p under ISO reduced the protective effect of 1% ISO against myocardial cell damage. +lncRNA target 34181232 hsa-mir-543 Triple Negative Breast Neoplasms CONCLUSIONS: miR-543 influences the biological behavior of TNBC cells by directly targeting ACTL6A gene. +genetics_overexpression_promote 34181173 hsa-mir-17 Glioma 5p overexpression mitigated glioma progression, which was significantly inhibited with Circ-TLK1 upregulation. +genetics_overexpression_promote 34180760 hsa-mir-183 Nervous System Diseases This study provides a theoretical basis for elucidating the mechanism of mepivacaine-induced nerve cell damage, and overexpressed miR5p likely become a novel strategy to combat mepivacaine-induced nerve damage.Abbreviations:miRNA: Micro RNA; PDCD4: Programmed Cell Death 4; MDA: Malondialdehyde; SOD: Superoxide Dismutase; ROS: Reactive Oxygen Species; WT: Wild Type; Mut: Mutant; UTR: Untranslated Region; IL-6: Interleukin-6; IL-1beta: Interleukin-1beta; TNF-alpha: Tumor Necrosis Factor-alpha; IL-8: Interleukin-8; COX-2: Cyclooxygenase-2; iNOS: inducible NOS; MEP: Mepivacaine. +genetics_overexpression_promote 34180758 hsa-mir-141 Carcinoma, Endometrioid The overexpression of miR +circRNA target 34180753 hsa-mir-1205 Breast Neoplasms In conclusion, our study suggests that circRASSF2 regulates BC progression through the miR-1205/HOXA1 pathway. +circulation_biomarker_prognosis_ns 34180348 hsa-mir-155 Ischemic Stroke Serum miR-155 demonstrated a favorable function in predicting the development and prognosis of CIS (P < 0.001). +other 34180329 hsa-mir-199 Prostatic Diseases Hsa-miR-143 and hsa-miR-199 were among the most prominent of the differentially expressed miRNAs upregulated in samples with prostate pathology but not vasectomy. +other 34180329 hsa-mir-143 Prostatic Diseases Hsa-miR-143 and hsa-miR-199 were among the most prominent of the differentially expressed miRNAs upregulated in samples with prostate pathology but not vasectomy. +other 34180127 hsa-mir-29b-2 Pulmonary Fibrosis Further, the ectopic expression of miR-29b5p and miR-34c-3p with chemotherapy attenuated silica-induced pulmonary fibrosis in vivo. +other 34180127 hsa-mir-34c Pulmonary Fibrosis Further, the ectopic expression of miR-29b5p and miR-34c-3p with chemotherapy attenuated silica-induced pulmonary fibrosis in vivo. +lncRNA target 34180119 hsa-mir-17 Acute Lung Injury Taken together, our results indicate that HOTAIR regulated apoptosis, the cell cycle, proliferation and autophagy through the miR5p/ATG2/ATG7/ATG16 axis, thus driving LPS-induced ALI. +genetics_overexpression_suppress 34180077 hsa-mir-140 Breast Neoplasms 3p overexpression and syndecan-4 silencing increased the adhesion of BC to fibronectin and laminin. +circulation_biomarker_diagnosis_down 34179516 hsa-mir-1914 Cardiovascular Diseases The expression of circulating miR5p is reportedly downregulated in patients with cardiovascular diseases. +other 34179503 hsa-mir-141 Uterine Cervical Neoplasms The sensitivity and the specificity of miR-141 for diagnosis of CSCC were 95.0% and 60.8%, respectively, while those of miR-340 for diagnosis of HSIL were 90.0 and 48.6%, respectively. +other 34179503 hsa-mir-340 Uterine Cervical Neoplasms The sensitivity and the specificity of miR-141 for diagnosis of CSCC were 95.0% and 60.8%, respectively, while those of miR-340 for diagnosis of HSIL were 90.0 and 48.6%, respectively. +lncRNA target 34179313 hsa-mir-200 Carcinoma, Hepatocellular The expression profile of microRNA-200 (miR-200) families is different in hepatocellular carcinoma. miR-200 and their downstream genes might be the potentially specific targets for the treatment of hepatocarcinoma. +lncRNA target 34179092 hsa-mir-1827 Ovarian Neoplasms Conclusion: These integrated bioinformatic analyses indicated that miRNA-1827 was dramatically downregulated in ovarian cancer as a tumor suppressor. Thus, the present study has identified miRNA-1827 as a potential intervention target for ovarian cancer based on our bioinformatic analysis processes. +circulation_biomarker_diagnosis_ns 34179081 hsa-mir-19a Breast Neoplasms plasma miR-10b, miR-19a, miR-20a, miR-126 and miR-155, which regulate immune response in breast cancer progression and are associated with the outcomes of breast cancer patients. +circulation_biomarker_diagnosis_ns 34179081 hsa-mir-126 Breast Neoplasms plasma miR-10b, miR-19a, miR-20a, miR-126 and miR-155, which regulate immune response in breast cancer progression and are associated with the outcomes of breast cancer patients. +circulation_biomarker_diagnosis_ns 34179081 hsa-mir-20a Breast Neoplasms plasma miR-10b, miR-19a, miR-20a, miR-126 and miR-155, which regulate immune response in breast cancer progression and are associated with the outcomes of breast cancer patients. +circulation_biomarker_diagnosis_ns 34179081 hsa-mir-10b Breast Neoplasms plasma miR-10b, miR-19a, miR-20a, miR-126 and miR-155, which regulate immune response in breast cancer progression and are associated with the outcomes of breast cancer patients. +circulation_biomarker_diagnosis_ns 34179081 hsa-mir-155 Breast Neoplasms plasma miR-10b, miR-19a, miR-20a, miR-126 and miR-155, which regulate immune response in breast cancer progression and are associated with the outcomes of breast cancer patients. +target gene 34178988 hsa-mir-186 Stomach Neoplasms LncRNA HCP5 Induces Gastric Cancer Cell Proliferation, Invasion, and EMT Processes Through the miR-186-5p/WNT5A Axis Under Hypoxia. +genetics_overexpression_suppress 34178974 hsa-mir-124 Cleft Palate Among them, overexpression of miR-27a-3p, miR-27b-3p, and miR +lncRNA target 34178725 hsa-mir-548d American Tegumentary Leishmaniasis As miR-548d-3p was predicted to target the chemokine pathway and inflammation is a central to the pathogenesis of ATL, we evaluated the effect of transient transfection of a miR-548d-3p inhibitor on L. Our data suggest miR-548d-3p could be further evaluated as a prognostic marker for ATL and/or as a host-directed therapeutic target. +lncRNA target 34178725 hsa-mir-548d Inflammation As miR-548d-3p was predicted to target the chemokine pathway and inflammation is a central to the pathogenesis of ATL, we evaluated the effect of transient transfection of a miR-548d-3p inhibitor on L. Our data suggest miR-548d-3p could be further evaluated as a prognostic marker for ATL and/or as a host-directed therapeutic target. +other 34178670 hsa-mir-1271 Colorectal Neoplasms 3p in the colon; E2F8 in the rectum and DMD and hsa-miR-130b-3p in the rectosigmoid junction. +other 34178670 hsa-mir-130a Colorectal Neoplasms 3p in the colon; E2F8 in the rectum and DMD and hsa-miR-130b-3p in the rectosigmoid junction. +other 34178670 hsa-mir-495 Colorectal Neoplasms 3p in the colon; E2F8 in the rectum and DMD and hsa-miR-130b-3p in the rectosigmoid junction. +other 34178670 hsa-mir-130b Colorectal Neoplasms 3p in the colon; E2F8 in the rectum and DMD and hsa-miR-130b-3p in the rectosigmoid junction. +target gene 34178650 hsa-mir-193b Uterine Cervical Neoplasms N(6)-Methyladenosine Associated Silencing of miR-193b Promotes Cervical Cancer Aggressiveness by Targeting CCND1. +other 34178135 hsa-mir-142 Stomach Neoplasms Long non-coding RNA NEAT1 increases the aggressiveness of gastric cancer by regulating the microRNA-142-5p/JAG1 axis. +exosome 34178037 hsa-mir-150 Endometrial Fibrosis CONCLUSION: ADSC-Exos mediate lncRNA-MIAT alleviation of endometrial fibrosis by regulating miR5p, which suggests that lncRNA-MIAT from ADSC-Exos may be a viable treatment for endometrial fibrosis. +lncRNA target 34178027 hsa-mir-874 Intervertebral Disc Degeneration Functionally, circ_0040039 could enhance NPC apoptosis and inhibit NPC growth, revealing that circ_0040039 might aggravate IDD by stabilizing miR +other 34177591 hsa-mir-489 Stomach Neoplasms Levobupivacaine Induces Ferroptosis by miR-489-3p/SLC7A11 Signaling in Gastric Cancer. +other 34177568 hsa-mir-34a Myocardial Infarction CONCLUSION: RSV rejuvenated BMSCs after chronic hyperglycemia-induced senescence by interacting with miR-34a and optimized the therapeutic effect of BMSCs on diabetes with myocardial infarction. +transcription factor target 34177264 hsa-mir-9 Reperfusion Injury, Cerebral Ischemia CONCLUSION: Our study suggests that inhibition of miR3p protects against cerebral I/R injury through activating GSK-3beta/Nrf2/ARE signaling-mediated antioxidant responses by targeting FGF19, providing a potential therapeutic target for ischemic stroke. +lncRNA target 34176781 hsa-mir-637 Carcinoma, Non-Small-Cell Lung CONCLUSION: Downregulation of miR-637 in NSCLC was associated with TNM stage and poor prognosis of patients and served as a tumor suppressor in NSCLC. +lncRNA target 34176471 hsa-mir-4306 Thyroid Cancer, Papillary CONCLUSION: ILF3-AS1 plays tumor-promoting role in PTC via targeting miR-4306/PLAGL2 axis. +exosome 34176265 hsa-mir-155 Squamous Cell Carcinoma of Head and Neck Taken together, our findings, for the first time, established that the miR-155 inhibitor-loaded exosomes reverse chemoresistance in oral cancer, thereby providing an alternative therapeutic strategy for the management of refractory oral cancer patients. +other 34175436 hsa-mir-142 Tuberculosis 3p and the LASSO cox prediction model based on HMGA1 and CAPN1 have potential value for forecasting TB (AUC > 0.7). +other 34175436 hsa-mir-140 Tuberculosis 3p and the LASSO cox prediction model based on HMGA1 and CAPN1 have potential value for forecasting TB (AUC > 0.7). +other 34175401 hsa-mir-200a Ovarian Neoplasms Also, the expression of miRNA-21, miRNA-200a, miRNA-130a and mi-RNA-224 (which are indicators of poor prognosis of ovarian cancer) decreased significantly. +other 34175401 hsa-mir-130a Ovarian Neoplasms Also, the expression of miRNA-21, miRNA-200a, miRNA-130a and mi-RNA-224 (which are indicators of poor prognosis of ovarian cancer) decreased significantly. +other 34175401 hsa-mir-21 Ovarian Neoplasms Also, the expression of miRNA-21, miRNA-200a, miRNA-130a and mi-RNA-224 (which are indicators of poor prognosis of ovarian cancer) decreased significantly. +lncRNA target 34175330 hsa-mir-126 Diabetes Mellitus Therefore, regulatory processes through mir-126, which are influenced by aerobic exercise, can be a valuable strategy in developing new treatments for diabetes. +circulation_biomarker_prognosis_ns 34175168 hsa-mir-93 Carcinoma, Hepatocellular CONCLUSIONS: Plasma and urine miR +other 34175151 hsa-mir-371a Testicular Germ Cell Tumor Levels of miR-371a-3p correlate with primary tumour mass, clinical stage, and International Germ Cell Cancer Collaborative Group risk groups. +circulation_biomarker_diagnosis_ns 34175151 hsa-mir-367 Testicular Germ Cell Tumor OBJECTIVE: To systematically evaluate the evidence for clinical applications of serum levels of miR302/367 and miR371-3 in adult testicular GCTs in terms of primary diagnosis, various clinical scenarios, and the costs of clinical implementation. +circulation_biomarker_diagnosis_ns 34175151 hsa-mir-371 Testicular Germ Cell Tumor OBJECTIVE: To systematically evaluate the evidence for clinical applications of serum levels of miR302/367 and miR371-3 in adult testicular GCTs in terms of primary diagnosis, various clinical scenarios, and the costs of clinical implementation. +lncRNA target 34174974 hsa-mir-665 Stomach Neoplasms In gastric cancer tissues and cells, the expression of circSFMBT2 was up-regulated, and the expression of miR-665 was down-regulated. It was concluded that paeonol can inhibit the proliferation, migration, invasion and glutamine decomposition of gastric cancer HGC-27 cells via circSFMBT2/miR-665 axis, and also induce cell apoptosis. +other 34174955 hsa-mir-205 Diabetic Nephropathies CONCLUSION: All data have manifested that circ-ACTR2 contributed to the HG-induced DN progression in HRMCs by the mediation of miR5p/HMGA2 axis. +lncRNA target 34174908 hsa-mir-181a Endometrial Neoplasms DLEU2 acted as an upstream activator for HK2-induced EMT and glycolysis in EC cells through two distinct mechanisms: (i) DLEU2 induced HK2 expression by competitively binding with miR-455, and (ii) DLEU2 also interacted with EZH2 to silence a direct inhibitor of HK2, miR-181a. +lncRNA target 34174908 hsa-mir-455 Endometrial Neoplasms DLEU2 acted as an upstream activator for HK2-induced EMT and glycolysis in EC cells through two distinct mechanisms: (i) DLEU2 induced HK2 expression by competitively binding with miR-455, and (ii) DLEU2 also interacted with EZH2 to silence a direct inhibitor of HK2, miR-181a. +circulation_biomarker_diagnosis_up 34174519 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck RESULTS: Exosomal miR-155 and miR-21 were significantly upregulated, and exosomal miR-126 was dramatically downregulated in the primary OSCC cells and the serum of OSCC patients. CONCLUSION: Exosomal miR-155 and miR-21 are oncogenic miRNAs which suppress PTEN and Bcl-6 expression, and exosomal miR-126 acts as a tumor suppressor which downregulates EGFL7 in OSCC. +circulation_biomarker_diagnosis_up 34174519 hsa-mir-155 Squamous Cell Carcinoma of Head and Neck RESULTS: Exosomal miR-155 and miR-21 were significantly upregulated, and exosomal miR-126 was dramatically downregulated in the primary OSCC cells and the serum of OSCC patients. CONCLUSION: Exosomal miR-155 and miR-21 are oncogenic miRNAs which suppress PTEN and Bcl-6 expression, and exosomal miR-126 acts as a tumor suppressor which downregulates EGFL7 in OSCC. +lncRNA target 34174438 hsa-mir-122 Brain Injuries 5p administration may be an attractive therapeutic target in RBI, providing new insights for clinical trials. +lncRNA target 34173813 hsa-mir-125b Myocardial Infarction The rat model also indicated that Carv might suppress the progression of acute myocardial infarction by regulating the levels of circ_NFIX, miR-125b-5p, and TLR4. +other 34173804 hsa-mir-106a Myocardial Reperfusion Injury In patients with acute myocardial infarction and in H/R cardiomyocytes and ischemia/reperfusion myocardium, the expression levels of FGD5-AS1 were reduced, whereas the expression levels of miR-106a-5p and miR-106b-5p were increased. +other 34173804 hsa-mir-106b Myocardial Reperfusion Injury In patients with acute myocardial infarction and in H/R cardiomyocytes and ischemia/reperfusion myocardium, the expression levels of FGD5-AS1 were reduced, whereas the expression levels of miR-106a-5p and miR-106b-5p were increased. +circulation_biomarker_diagnosis_ns 34173728 hsa-mir-20a Ischaemic Heart Disease 5p were increased in DCM compared with IHD (P < 0.005) and serum levels of miR-320a were elevated in DCM compared with healthy controls (P < 0.05). +circulation_biomarker_diagnosis_ns 34173728 hsa-mir-20a Cardiomyopathy, Dilated 5p were increased in DCM compared with IHD (P < 0.005) and serum levels of miR-320a were elevated in DCM compared with healthy controls (P < 0.05). +circulation_biomarker_diagnosis_ns 34173728 hsa-mir-29 Ischaemic Heart Disease 5p were increased in DCM compared with IHD (P < 0.005) and serum levels of miR-320a were elevated in DCM compared with healthy controls (P < 0.05). +circulation_biomarker_diagnosis_ns 34173728 hsa-mir-29 Cardiomyopathy, Dilated 5p were increased in DCM compared with IHD (P < 0.005) and serum levels of miR-320a were elevated in DCM compared with healthy controls (P < 0.05). +other 34173712 hsa-mir-525 Triple Negative Breast Neoplasms In conclusion, LINC01234 aggravated TNBC cell growth, migration, invasion and EMT by modulating the miR5p/MEIS2 axis and activating the Wnt/beta-catenin signaling pathway. +lncRNA target 34173673 hsa-mir-433 Myocardial Reperfusion Injury Thus, our findings indicate that NOB could effectively relieve H/R-induced damage in H9c2 cells by modulating the miR-433/SIRT1 axis, suggesting that nobiletin may be a potential drug for the treatment of myocardial ischemia-reperfusion injury. Furthermore, this study also identified another potential therapeutic target, miR-433, for the treatment of myocardial ischemia-reperfusion injury. +genetics_GWAS 34172780 hsa-mir-146a Sepsis Taken together, these results demonstrated that the 29940 G-to-C mutation within the NLRP3 3'-UTR was a gain-of-function alteration that caused the suppression of NLRP3 expression and downstream inflammatory cytokine production via binding with miR-146a, which ultimately protected patients against susceptibility to sepsis progression and poor clinical outcome. +circulation_biomarker_diagnosis_ns 34171684 hsa-mir-155 Multiple Sclerosis, Relapsing-Remitting The study aims at investigating the expression of miR-155, ICAM1, ITGB2, perforin and GranzymeB in CD8+ T cells of RRMS patients receiving different treatment regimens and how these genes correlate with patients' EDSS and miR-155 expression. METHODS: Gene expression of miR-155, ICAM1, ITGB2, perforin and granzymeB was evaluated using RT-qPCR in CD8+ T cells isolated from blood samples of RRMS patients and compared to healthy controls. +lncRNA target 34171541 hsa-mir-379 Glioma 5p could regulate glioma cell viability, migration, invasion and EMT through MGST1, suggesting that miR +genetics_overexpression_promote 34171521 hsa-mir-101 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma MiR-101 mimic inhibited viability, migration and invasion of T-ALL cells, and reversed effects of overexpressed LINC00665, whilst miR-101 inhibitor reversed the effects of LINC00665 silencing. +lncRNA target 34171363 hsa-mir-424 Coronary Disease Taken together, this study demonstrated that THRIL inhibition alleviates myocardial injury in CHD possibly through the miR-424/TXNIP/p53 axis. +transcription factor target 34170852 hsa-mir-143 Prostatic Neoplasms ZQD treatment could promote apoptosis of prostate cancer cells by promoting miR-143 upregulation, which could be a possible mechanism underlying the inhibitory effect of ZQD in prostate cancer in patient. +genetics_overexpression_promote 34170494 hsa-mir-28 Carcinoma, Renal Cell 5p activity or overexpressing HMGA1, indicating that ITGB2-AS1 promotes the survival and progression of ccRCC by modulating miR +lncRNA target 34170484 hsa-mir-885 Cholangiocarcinoma 5p/MTPN axis may serve as a target for improving the sensitivity of CCA cells to chemotherapy. +genetics_overexpression_promote 34170291 hsa-mir-224 Colorectal Neoplasms 5p increased the proliferative, migratory and invasive abilities of CRC cells and inhibit CRC cell apoptosis, while overexpressing SLC4A4 caused the opposite result. +genetics_overexpression_suppress 34170070 hsa-mir-1 Colorectal Neoplasms Overexpression or inhibition of miRNA-31 further confirmed the change in its expression in colorectal cancer cell lines. +other 34169968 hsa-mir-185 Tuberculosis Eventually, miR5p was collected as a promising potential biomarker for tuberculosis. +other 34169732 hsa-mir-95 Colorectal Neoplasms five miR rarely described before could be potential actors of anti-EGFR monoclonal antibody resistance: miR-95-3p, miR-139-5p, miR-145-5p, miR-429 and miR-1247-5p. +other 34169732 hsa-mir-145 Colorectal Neoplasms five miR rarely described before could be potential actors of anti-EGFR monoclonal antibody resistance: miR-95-3p, miR-139-5p, miR-145-5p, miR-429 and miR-1247-5p. +other 34169732 hsa-mir-139 Colorectal Neoplasms five miR rarely described before could be potential actors of anti-EGFR monoclonal antibody resistance: miR-95-3p, miR-139-5p, miR-145-5p, miR-429 and miR-1247-5p. +other 34169732 hsa-mir-1247 Colorectal Neoplasms five miR rarely described before could be potential actors of anti-EGFR monoclonal antibody resistance: miR-95-3p, miR-139-5p, miR-145-5p, miR-429 and miR-1247-5p. +other 34169732 hsa-mir-429 Colorectal Neoplasms five miR rarely described before could be potential actors of anti-EGFR monoclonal antibody resistance: miR-95-3p, miR-139-5p, miR-145-5p, miR-429 and miR-1247-5p. +lncRNA target 34169675 hsa-mir-411 Prostatic Neoplasms 5p inhibits PCa progression. +circRNA target 34169652 hsa-mir-326 Atherosclerosis In conclusion, circ_0002984 mediated cell proliferation, migration and inflammation through modulating miR3p and VAMP3 in VSMCs, which suggested that circ_0002984 might hold great promise as a therapeutic strategy for atherosclerosis. +lncRNA target 34169384 hsa-mir-181b Cholangiocarcinoma The present data indicated miR-181b-5p acted as an oncogene in CCA through promoting tumor cell proliferation, migration, and invasion of CCA via the PTEN/PI3K/AKT signaling pathway by targeting PARK2, which might be a promising therapeutic target or biomarker for CCA. +lncRNA target 34169096 hsa-mir-592 Uterine Cervical Neoplasms Importantly, functional research findings indicated that lncRNA MEF2C-AS1 inhibited CC via suppressing miR-592 by targeting RSPO1. +target gene 34169001 hsa-mir-27 Triple Negative Breast Neoplasms miR-27-3p Enhances the Sensitivity of Triple-Negative Breast Cancer Cells to the Antitumor Agent Olaparib by Targeting PSEN-1, the Catalytic Subunit of Γ-Secretase. +other 34168984 hsa-mir-136 Wilms Tumor In conclusion, our study discovered the biological role of the circ0093740-miR-136/145-DNMT3A axis in Wilms tumor growth and metastasis which is important for developing new treatment strategy. +other 34168917 hsa-mir-296 Carcinoma, Hepatocellular 5p) to positively modulate E2F transcription factor 2 (E2F2) and SRY-box transcription factor 12 (SOX12) in HCC cells. +lncRNA target 34168916 hsa-mir-593 Glioblastoma We demonstrated that circMELK was upregulated in GBM, acting as an oncogene and regulating GBM mesenchymal transition and GSC maintenance via sponging of miR-593. Furthermore, we found that EphB2 was involved in circMELK/miR-593 axis-induced GBM tumorigenesis. +other 34168648 hsa-mir-215 Tuberculosis A decision-tree algorithm identified gamma-glutamylthreonine and hsa-miR5p as the optimal variables to classify incident TB cases (AUC 0.965; 95% CI 0.925-1.000). +other 34168648 hsa-mir-215 Acquired Immunodeficiency Syndrome A decision-tree algorithm identified gamma-glutamylthreonine and hsa-miR5p as the optimal variables to classify incident TB cases (AUC 0.965; 95% CI 0.925-1.000). +transcription factor target 34168462 hsa-mir-145 Melanoma Furthermore, BGM inhibited the progression of melanoma by targeting miR-145/Cyclin D1 axis in vitro. +circulation_biomarker_diagnosis_up 34168120 hsa-mir-217 Pancreatic Carcinoma Subsequently, miR-217 suppressed PC cell proliferation and metastasis by directly targeting YWHAG, which interacted with RAF1 and promoted its phosphorylation, leading to RAF1-mediated ERK signaling activation and translocation of phosphorylated ERK from the cytoplasm to the nucleus. +lncRNA target 34168116 hsa-mir-510 Carcinoma, Pancreatic Ductal Collectively, present findings reveal that circSLIT2/miR5p/c-Myc/LDHA axis participates in the aerobic glycolysis and carcinogenesis of PDAC, and may act as a promising therapeutic target. +other 34167625 hsa-mir-424 Solitary Pulmonary Nodule sEVs-miR5p could be a novel biomarker for distinguishing SSN from LC and BN populations. +other 34167624 hsa-mir-147 Squamous Cell Carcinoma of Head and Neck In conclusion, this study found that IRX5 plays a role in promoting cancer in OSCC, and IRX5 is also negatively regulated by miRNA-147. +circulation_biomarker_diagnosis_ns 34167618 hsa-mir-155 Primary Myelofibrosis The proposed novel fluorescent probe based on the DSN can be used to detect miRNA-155 in human serum and provide a potential, convenient and reliable tool for diagnosis of MM. +other 34167618 hsa-mir-155 Multiple Myeloma MicroRNA-155 (miRNA-155) as a characteristic myeloma-associated biomarker exhibits significant potential application in the diagnosis of multiple myeloma (MM). +transcription factor target 34167441 hsa-mir-9 Leukemia, Myeloid Taken together, miR-9 may act as a tumor suppressor by activating the Hippo/YAP signaling pathway of AML cells, which in this way supply ideas for the clinical remedy of AML patients. +transcription factor target 34167441 hsa-mir-9 Ischemic Stroke Taken together, miR-9 may act as a tumor suppressor by activating the Hippo/YAP signaling pathway of AML cells, which in this way supply ideas for the clinical remedy of AML patients. +genetics_overexpression_promote 34167436 hsa-mir-4486 Stomach Neoplasms miR-4486 overexpression could decrease viability and improve apoptosis of SGC-7901/DDP cells to revert its cisplatin-resistance, and the mechanism may be related to JAK3/STAT3 signalling pathway. +other 34166944 hsa-mir-21 Breast Neoplasms As a proof of concept, the self-assembled AuAg NCs is successfully applied in the ultrasensitive detection of breast cancer biomarker microRNAs-21 (miR-21), which guides a new pathway for creating high-quality nano-optical elements in chemical sensors, biological imaging, and lightemitting devices. +exosome 34166712 hsa-mir-143 Myocardial Reperfusion Injury SIGNIFICANCE: Collectively, our results indicated that MSCs-derived exosomal miR3p might represent a promising option for the treatment of I/R injury. +circulation_biomarker_diagnosis_ns 34165827 hsa-mir-498 Osteoarthritis RESULTS: RUNX2-derived hsa_circ_0005526 (circ_RUNX2) is significantly highly expressed in OA serum and mainly located in the cytoplasm within the cartilage cell by sponging multiple miRNAs (miR-498, miR-924, miR3p, and miR-665). +circulation_biomarker_diagnosis_ns 34165827 hsa-mir-924 Osteoarthritis RESULTS: RUNX2-derived hsa_circ_0005526 (circ_RUNX2) is significantly highly expressed in OA serum and mainly located in the cytoplasm within the cartilage cell by sponging multiple miRNAs (miR-498, miR-924, miR3p, and miR-665). +other 34165388 hsa-mir-152 Sepsis 3p was up-regulated in sepsis patients and LPS-stimulated HPAEpiC. +other 34165388 hsa-mir-152 Acute Lung Injury 3p was up-regulated in sepsis patients and LPS-stimulated HPAEpiC. +circRNA target 34165176 hsa-mir-619 Thyroid Cancer, Papillary From these analyses, one PTCrelated miRNA (hsamiR36195p) was identified as a potential target for hsa_circ_IPCEF1 sponging, indicating the hsa_circ_IPCEF1/hsamiR36195p axis in pathogenesis. +genetics_overexpression_suppress 34165171 hsa-mir-486 Nasopharyngeal Carcinoma Finally, the effects of SLC9A3AS1 silencing on NPC cells were reversed by inhibiting miR4865p or overexpressing E2F6. In summary, SLC9A3AS1 exerted carcinogenic effects on NPC cells by adjusting the miR4865p/E2F6 axis. +lncRNA target 34165168 hsa-mir-10b Lung Neoplasms These findings indicate a novel pathway in which cisplatin induces the levels of p53 by increasing mRNA stability via miR10b, indicating a novel oncogenic role of miR10b in promoting the malignant characteristics of nonsmall cell lung carcinoma. +lncRNA target 34165162 hsa-mir-223 Seizures, Febrile Therefore, the results from the present study collectively suggested that treatment with MT alleviated FC via the MEG3/miR223/PTEN/AKT pathway, which also indicated that MT could be considered as a novel strategy for the treatment of FC disease. +lncRNA target 34165160 hsa-mir-205 Lung Neoplasms Reverse transcriptionquantitative PCR was performed, which determined that miR205 expression was upregulated in NSCLC, and the present study detected the upregulation of miR2053p in a number of NSCLC cell lines and NSCLC tissues. Thus, the current findings highlighted the potential promotive impact of miR2053p on NSCLC processes and may provide theoretical evidence for miR2053p as a potential clinical gene therapy target. +other 34165154 hsa-mir-148a Atherosclerosis The present study aimed to investigate the role of the Kruppellike factor 5 (KLF5)/LINC00346/miR148a3p loop in AS. +genetics_overexpression_suppress 34165008 hsa-mir-126 Arthritis, Rheumatoid In addition, overexpression of miR +genetics_knock down_promote 34164963 hsa-mir-495 Osteoarthritis SOX9 was downregulated in the damaged cartilage tissues of patients with OA, and knockdown of SOX9 abolished the effect of anti-miR-495 on IL-1beta-treated TC28a2 cells. +other 34164962 hsa-mir-144 Squamous Cell Carcinoma of Head and Neck 3p expression and increasing EZH2 expression. +lncRNA target 34164910 hsa-mir-21 Pulmonary Fibrosis However, whether miR-21 mediates obstructive renal fibrosis through the same signalling pathway has not been determined. +other 34164896 hsa-mir-1200 Alcoholism Among these, circRNA-406742 and miR-1200 significantly interact with the highest number of mRNA, including genes associated with neuronal functioning and alcohol addiction (HRAS, PRKCB, HOMER1, and PCLO). +genetics_knock down_suppress 34164774 hsa-mir-340 Osteosarcoma In conclusion, circ-CHI3L1.2 levels were increased in cisplatin-resistant osteosarcoma cells and circ-CHI3L1.2 knockdown sensitized cisplatin-resistant osteosarcoma cells to cisplatin through the miR5p-LPAATbeta axis. +lncRNA target 34164767 hsa-mir-942 Thyroid Neoplasms Overall, silencing of hsa_circ_0001681 significantly suppressed TC progression through inhibiting EMT via acting as a miR +genetics_overexpression_promote 34164498 hsa-mir-211 Cicatrix, Hypertrophic 5p could target TGFbetaR2 (all P<0.05), and when hHSFs cells simultaneously overexpressed miR +lncRNA target 34164494 hsa-mir-637 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: CircHIPK3 demonstrates potential as a prognostic marker of OSCC and mediates OSCC progression via the miRmediated NUPR1/PI3K/AKT axis. +genetics_overexpression_promote 34164486 hsa-mir-664a Polycystic Ovary Syndrome Moreover, our results confirmed that miR-664a-3p directly targets BCL2A1 (P<0.05), and the inhibitory effect of miR-664a-3p on KGN cells was reversed by BCL2A1 overexpression (both P<0.05). +other 34164485 hsa-mir-216a Parkinson Disease Long non-coding RNA SNHG1 mediates neuronal damage in Parkinson's disease model cells by regulating miR-216a-3p/Bcl-2-associated X protein. +genetics_knock down_promote 34164475 hsa-mir-758 Osteosarcoma In OS cells, migration, invasion, and epithelial-mesenchymal transformation (EMT) was promoted by overexpression of XIST and miR-758 inhibitor, but were inhibited by XIST knockdown and miR-758 mimics. +circulation_biomarker_diagnosis_up 34164201 hsa-mir-146a Acute Coronary Syndrome CONCLUSIONS: The serum exo-miR-146a may be used as a novel diagnostic biomarker for ACS patients, and it is also associated with inflammatory response. +circulation_biomarker_prognosis_up 34163524 hsa-mir-1246 Carcinoma, Hepatocellular The expression levels of serum miR-497 and miR-1246 were significantly associated with the diagnosis, prognosis, and overall survival rate of patients with HCC. +genetics_overexpression_promote 34163467 hsa-mir-186 Myocardial Infarction Concludingly, the overexpression of TUG1 alleviates NLRP3 inflammasome-mediated cardiomyocyte pyroptosis through targeting the miR +genetics_overexpression_promote 34163467 hsa-mir-186 Cardiomyopathies Concludingly, the overexpression of TUG1 alleviates NLRP3 inflammasome-mediated cardiomyocyte pyroptosis through targeting the miR +circulation_biomarker_diagnosis_up 34163374 hsa-mir-23a Sarcopenia In aging patients, plasma miR-23a-3p, miR +circulation_biomarker_diagnosis_up 34163374 hsa-mir-93 Sarcopenia In aging patients, plasma miR-23a-3p, miR +circulation_biomarker_diagnosis_up 34163374 hsa-mir-637 Fractures, Bone In aging patients, plasma miR-23a-3p, miR +circulation_biomarker_diagnosis_up 34163374 hsa-mir-23a Fractures, Bone In aging patients, plasma miR-23a-3p, miR +circulation_biomarker_diagnosis_up 34163374 hsa-mir-93 Fractures, Bone In aging patients, plasma miR-23a-3p, miR +circulation_biomarker_diagnosis_up 34163374 hsa-mir-637 Sarcopenia In aging patients, plasma miR-23a-3p, miR +other 34163215 hsa-mir-637 cervical squamous cell carcinoma miR-637 and RXRB mRNA expression levels in CSCC patients were examined using quantitative PCR. CONCLUSION: These findings suggest that the rs2072915 T > A change might augment the binding energy of miR-637 to RXRB, result in lower levels of RXRB, and thus contribute to the risk of CSCC. +lncRNA target 34163177 hsa-mir-544b Carcinoma, Hepatocellular This study clarified the role of MEG3/miR-544b/BTG2 axis in HCC and also provided new targets for HCC research. +target gene 34163175 hsa-mir-593 Prostatic Neoplasms miR-593-3p Promotes Proliferation and Invasion in Prostate Cancer Cells by Targeting ADIPOR1. +transcription factor target 34163033 hsa-mir-142 Ovarian Neoplasms Taken together, our findings unveil a novel homeostatic loop of SRI that drives the PTX-resistance and malignant progression via Smad4/ZEB1/miR5p in human OC. +lncRNA target 34162830 hsa-mir-127 Stomach Neoplasms 5p-SORT1 pathway, and our study provides novel insight for the identification of diagnostic/prognostic biomarkers and therapeutic targets for GC. +transcription factor target 34162761 hsa-mir-27b Stomach Neoplasms miR-27b-3p was confirmed with the binding site with PAX4 using ChIP assay and served as a tumor suppressor that inhibiting GC cell growth and metastasis, and reversed the effect of PAX4. Taken together, the PAX4/miR-27b-3p/Grb2 loop is known to be involved in GC cell promotion, and can be seen as a promising target for GC therapy. +lncRNA target 34162562 hsa-mir-98 Esophageal Squamous Cell Carcinoma 5p, in the treatment of esophageal squamous cell carcinoma. +lncRNA target 34162560 hsa-mir-93 Pancreatic Carcinoma 5p modulates tumorigenesis and gemcitabine resistance in PC cells via targeting the PTEN/PI3K/Akt signaling pathway. +lncRNA target 34162557 hsa-mir-132 Breast Neoplasms 3p enhanced VP16-induced breast cancer cell apoptosis through targeting GSK3B. +circulation_biomarker_diagnosis_ns 34162296 hsa-mir-28 Carotid Stenosis RESULTS: Serum miR +lncRNA target 34162150 hsa-mir-140 Osteoarthritis 5p effectively alleviate EOA progression by modulating multiple biological processes and pathways in rats, representing a promising therapeutic for EOA. +lncRNA target 34162147 hsa-mir-223 Sepsis meditated M2-type polarization of macrophages via targeting to Nfat5 and Rasa1 to control the progress of sepsis. +genetics_overexpression_promote 34161651 hsa-mir-19a Renal Insufficiency, Chronic This study tested the hypothesis that therapy with double overexpression of miR-19a-3p and miR-20a-5p (miR(DOE) ) to human inducible pluripotent stem cell-derived mesenchymal stem cells (iPS-MSCs) was superior to iPS-MSCs alone for preserving renal function in rat with pre-existing chronic kidney disease (CKD), followed by ischaemia-reperfusion (IR) injury. +genetics_overexpression_promote 34161651 hsa-mir-20a Renal Insufficiency, Chronic This study tested the hypothesis that therapy with double overexpression of miR-19a-3p and miR-20a-5p (miR(DOE) ) to human inducible pluripotent stem cell-derived mesenchymal stem cells (iPS-MSCs) was superior to iPS-MSCs alone for preserving renal function in rat with pre-existing chronic kidney disease (CKD), followed by ischaemia-reperfusion (IR) injury. +lncRNA target 34161325 hsa-let-7 Inflammation Let-7b is a member of the let-7 microRNA family and plays an inhibitory role in a variety of diseases and inflammatory conditions. +lncRNA target 34161325 hsa-let-7b Fibrosis CONCLUSION: Our research clarifies the role of let-7b in the inhibition of HSC activation by rSjP40 and will provide new insights and ideas for the inhibition of HSC activation and treatment of liver fibrosis. +lncRNA target 34161325 hsa-let-7b Inflammation Let-7b is a member of the let-7 microRNA family and plays an inhibitory role in a variety of diseases and inflammatory conditions. +genetics_overexpression_promote 34160894 hsa-mir-206 Osteoarthritis Overexpressed Elf3 reversed miR-206 up-regulation-induced effects on OA osteoblasts. +lncRNA target 34160887 hsa-mir-27a Ovarian Neoplasms We demonstrated that downregulation of the short isoform of UCA1 sensitized OC cells to cisplatin and that UCA1 acted as competing endogenous RNA to miR-27a-5p. In conclusion, response to treatment in patients with OC is regulated by the UCA1/miR-27a-5p/UBE2N axis, where UBE2N inhibition could potentially represent a novel therapeutic strategy to counter chemoresistance in OC. +genetics_overexpression_promote 34160745 hsa-mir-137 Glioma Additionally, EZH2 was a direct target of miR-137 and overexpressed EZH2 effectively reversed the effect of miR-137 on glioma proliferation and migration. +genetics_overexpression_promote 34160728 hsa-mir-483 Arthritis, Rheumatoid Overexpressed miR +exosome 34160339 hsa-mir-142 Osteoarthritis CONCLUSION: Exosomal PCGEM1 from OA-FLSs facilitated IL-1beta-induced apoptosis and cartilage matrix degradation in chondrocytes by sequestering miR +lncRNA target 34160338 hsa-mir-28 Stomach Neoplasms 3p inhibitor increased apoptosis and oxidative stress of human gastric cancer cells. +lncRNA target 34160186 hsa-mir-365 Infantile convulsions and paroxysmal choreoathetosis, familial 3p inhibited the differentiation of bMSCs into ICCs via targeting Pax6 and inhibiting the MEK/ERK pathway. +circulation_biomarker_diagnosis_up 34160076 hsa-mir-374b Stomatitis CONCLUSIONS: hsa-miR-374b-5p is upregulated in blood and ginvial cells exposed to oral inflammation and tobacco smoke and regulates UHMK1, which has a role in osteoclast differentiation. +lncRNA target 34159811 hsa-mir-142 Vitamin D Deficiency 3p, which suppresses autophagy. +lncRNA target 34159811 hsa-mir-142 Inflammatory Bowel Diseases 3p, which suppresses autophagy. +circulation_biomarker_diagnosis_ns 34159768 hsa-mir-29b Pulmonary Disease, Chronic Obstructive Firstly, miR-29b and interleukin (IL)-22 expression was assessed in serum of 20 healthy non-smokers, 20 healthy smokers and 20 COPD patients as well as CSE-treated HBE cells. +other 34159752 hsa-mir-891a Melanoma LINC02446, LINC01857, and LINC02384 may stimulate melanoma progression by reducing tumor-protecting miR.891a.5p and miR.203b.3p. +lncRNA target 34159524 hsa-mir-590 Fetal Growth Retardation 3p exhibits a growing trend during pregnancy, and its expression in middle and late pregnancy is associated with increased FGR risk via interaction with VEGF, PIGF, and MMP9. +genetics_knock down_suppress 34159436 hsa-mir-135b Stomach Neoplasms More importantly, blocking the SP1 function by Plicamycin, an SP1 inhibitor, abolished the effect of stable miR-135b-5p knockdown GC cell-derived exosomes on Vgamma9Vdelta2 T cell function. Collectively, our results suggest that GC cell-derived exosomes impair the function of Vgamma9Vdelta2 T cells via miR-135b-5p/SP1 pathway, and targeting exosomal miR-135b-5p/SP1 axis may improve the efficiency of GC immunotherapy based on Vgamma9Vdelta2 T cells. +other 34159082 hsa-mir-145 Penile Neoplasms CONCLUSIONS: Our data suggest that the underexpression of miR-145 may be triggered by HPV action, decreasing protein expression of p53, and being correlated with perineural invasion. +exosome 34159078 hsa-mir-155 Prostatitis CONCLUSIONS: Exosomes in the prostatic fluid and the miRNA-155 contained therein were may be involved with the pathogenesis of CP/CPPS-A. +other 34159075 hsa-mir-29c Urinary Bladder Neoplasms Moreover, the correlations between TTLL7 and resting mast cells (R=0.24, P<0.001), DSC2 and resting mast cells (R=-0.23, P<0.001), ELN and resting mast cells (R=0.44, P<0.001), and hsa-miR-29c-3p and M0 macrophages (R=-0.29, P<0.001) were significant, indicating that interactions of these factors may play significant roles in the prognosis of BC. CONCLUSIONS: TTLL7, DSC2, ELN, hsa-miR-29c-3p, resting mast cells, and M0 macrophages may play an important role in the development of BC. +other 34159074 hsa-mir-1193 Prostatic Neoplasms Additionally, it causes PCa cells to proliferate by negatively regulating miR-1193. +other 34158869 hsa-mir-486a Cardiomyopathies Conclusions: Our study demonstrates that elevated IgE promotes pathological cardiac fibrosis by modulating miR-486a-5p and downstream factors, such as Smad1. +other 34158869 hsa-mir-486 Cardiomyopathies Conclusions: Our study demonstrates that elevated IgE promotes pathological cardiac fibrosis by modulating miR-486a-5p and downstream factors, such as Smad1. +other 34158867 hsa-mir-375 Breast Neoplasms Conclusion: Our findings identified a crucial role of LDHB in macrophages and established tumor-derived miR-375 as a novel regulator of macrophage metabolism in breast cancer, which might pave the way for strategies of combinatorial cancer cell/stroma cell interventions. +genetics_overexpression_promote 34158819 hsa-mir-196a Thyroid Neoplasms Our study results manifested that miR-196a-2 was dramatically overexpressed in cells of TC, while NRXN1 was lowly expressed. +genetics_overexpression_promote 34158819 hsa-mir-196a-2 Thyroid Neoplasms Our study results manifested that miR-196a-2 was dramatically overexpressed in cells of TC, while NRXN1 was lowly expressed. +transcription factor target 34158627 hsa-mir-766 Colorectal Neoplasms 3p reduces the proliferation of CRC cells by targeting HNF4G expression and thus inhibits the PI3K/AKT pathway. +genetics_overexpression_promote 34158416 hsa-mir-24 Myocardial Infarction Moreover, TOLLIP overexpression debilitated the promotive role of miR +lncRNA target 34158095 hsa-mir-152 Osteoarthritis CONCLUSIONS: It was concluded that lncRNA CASC19 accelerated chondrocytes apoptosis and proinflammatory cytokine production to exacerbate osteoarthritis development through regulating the miR3p/DDX6 axis. +genetics_knock down_promote 34158077 hsa-mir-30 Prostatic Neoplasms Moreover, overexpression of miR +lncRNA target 34157861 hsa-mir-193b Metabolic Diseases Treatment of obese+sugen rats with empagliflozin improved metabolic syndrome, reduced mitochondrial reactive oxygen species and miR-193b levels, restored NFYA/sGC activity, and prevented EIPH. CONCLUSIONS: In heart failure with preserved ejection fraction and CpcPH models, metabolic syndrome contributes to pulmonary vascular dysfunction and EIPH through enhanced reactive oxygen species and miR-193b expression, which downregulates NFYA-dependent sGCbeta1 expression. +lncRNA target 34157861 hsa-mir-193b Heart Failure Treatment of obese+sugen rats with empagliflozin improved metabolic syndrome, reduced mitochondrial reactive oxygen species and miR-193b levels, restored NFYA/sGC activity, and prevented EIPH. CONCLUSIONS: In heart failure with preserved ejection fraction and CpcPH models, metabolic syndrome contributes to pulmonary vascular dysfunction and EIPH through enhanced reactive oxygen species and miR-193b expression, which downregulates NFYA-dependent sGCbeta1 expression. +lncRNA target 34157861 hsa-mir-193b Hypertension, Pulmonary Treatment of obese+sugen rats with empagliflozin improved metabolic syndrome, reduced mitochondrial reactive oxygen species and miR-193b levels, restored NFYA/sGC activity, and prevented EIPH. CONCLUSIONS: In heart failure with preserved ejection fraction and CpcPH models, metabolic syndrome contributes to pulmonary vascular dysfunction and EIPH through enhanced reactive oxygen species and miR-193b expression, which downregulates NFYA-dependent sGCbeta1 expression. +genetics_knock down_promote 34157832 hsa-mir-338 Osteosarcoma 3p level in OS cells after knockdown of circRNA_103801 was elevated compared with the control group. +lncRNA target 34157472 hsa-mir-342 COVID-19 5p), targeting multiple host genes (MYC, IL6, ICAM1 and VEGFA) as well as SARS-CoV2 gene (ORF1ab) were identified. +lncRNA target 34157472 hsa-mir-432 COVID-19 5p), targeting multiple host genes (MYC, IL6, ICAM1 and VEGFA) as well as SARS-CoV2 gene (ORF1ab) were identified. +lncRNA target 34157472 hsa-mir-98 COVID-19 5p), targeting multiple host genes (MYC, IL6, ICAM1 and VEGFA) as well as SARS-CoV2 gene (ORF1ab) were identified. +lncRNA target 34157472 hsa-mir-17 COVID-19 5p), targeting multiple host genes (MYC, IL6, ICAM1 and VEGFA) as well as SARS-CoV2 gene (ORF1ab) were identified. +lncRNA target 34157350 hsa-mir-3180 Diabetes Mellitus, Type 2 5p targets could provide valuable information for the development of therapeutic drugs for type 2 diabetes. +lncRNA target 34157350 hsa-mir-4632 Diabetes Mellitus, Type 2 5p targets could provide valuable information for the development of therapeutic drugs for type 2 diabetes. +transcription factor target 34157155 hsa-mir-21 Liver Injury Therefore, we tested whether RSV can protect against BDL-induced liver fibrosis associated with the inhibition of the TGFbeta1-Smad3-miR21 axis and profibrogenic and hepatic injury biomarkers. These findings show that RSV at 30 mg/kg substantially protects against BDL-induced liver injuries, which is associated with the inhibition of TGFbeta1-Smad3-miR21 axis, and biomarkers of profibrogenesis, oxidative stress, and inflammation. +transcription factor target 34157155 hsa-mir-21 Cholestasis Therefore, we tested whether RSV can protect against BDL-induced liver fibrosis associated with the inhibition of the TGFbeta1-Smad3-miR21 axis and profibrogenic and hepatic injury biomarkers. These findings show that RSV at 30 mg/kg substantially protects against BDL-induced liver injuries, which is associated with the inhibition of TGFbeta1-Smad3-miR21 axis, and biomarkers of profibrogenesis, oxidative stress, and inflammation. +transcription factor target 34157155 hsa-mir-21 Diabetic Nephropathies Therefore, we tested whether RSV can protect against BDL-induced liver fibrosis associated with the inhibition of the TGFbeta1-Smad3-miR21 axis and profibrogenic and hepatic injury biomarkers. These findings show that RSV at 30 mg/kg substantially protects against BDL-induced liver injuries, which is associated with the inhibition of TGFbeta1-Smad3-miR21 axis, and biomarkers of profibrogenesis, oxidative stress, and inflammation. +other 34156885 hsa-mir-214 alpha-Thalassemia In this study, we illustrated the expressions of miR-214 and ATF4 in Hb H (beta4) disease, and Hb E (HBB: c.79G>A)/beta-thalassemia (beta-thal) reticulocyte samples. +genetics_overexpression_promote 34156675 hsa-mir-150 Squamous Cell Carcinoma of Head and Neck MiR-150 overexpression inhibited the abilities of viability, invasive and the EMT by targeting HMGA2 in OSCC cells. +transcription factor target 34156672 hsa-mir-296 Pre-Eclampsia 3p inactivates the Wnt/beta-catenin and PI3K/AKT pathways to promote the progression of PE via targeting the CEMIP. +transcription factor target 34156640 hsa-mir-99b Osteoporosis Within osteoporosis bone tissues, miR-99b-5p was upregulated and FGFR3 was downregulated. In conclusion, we identify a deregulated miRNA/mRNA axis in osteoporosis and osteogenic differentiation, namely the miR-99b-5p/FGFR3 axis; through targeting FGFR3, miR-99b-5p inhibits osteoblast proliferation and activity, which might subsequently affect the bone formation in osteoporosis progression. +other 34156425 hsa-mir-211 Glaucoma, Open-Angle 5p are implicated in POAG for the first time. +other 34156425 hsa-mir-221 Glaucoma, Open-Angle 5p are implicated in POAG for the first time. +other 34156425 hsa-mir-486 Glaucoma, Open-Angle 5p are implicated in POAG for the first time. +other 34156425 hsa-mir-92a Glaucoma, Open-Angle 5p are implicated in POAG for the first time. +other 34156425 hsa-mir-143 Glaucoma, Open-Angle 5p are implicated in POAG for the first time. +other 34155879 hsa-mir-29b Colorectal Neoplasms In conclusion, it is deduced that miR-29b-3p/TRAF5 signaling axis plays critical role in drug resistance in chemotherapy for colorectal cancer patients by regulating necroptosis. +lncRNA target 34155816 hsa-mir-98 Arthritis, Rheumatoid 5p mimic or inhibitor. +circulation_biomarker_diagnosis_ns 34155619 hsa-mir-181d Diabetes, Gestational MATERIAL AND METHODS: The serum samples were collected from patients with GDM and subjected to qRT-PCR to verify the potential altered the miR-181d expression. +exosome 34155579 hsa-mir-181a Reperfusion Injury I/R significantly up-regulated ABR threshold shift and promoted hair cell apoptosis indicated by parvalbumin and caspase-3 staining, while CSGPC-exos (0.5 mug/mul, 1.0 mug/mul) could diminish such damages with downregulated proinflammatory factors (IL-6, IL-1beta, TNF-alpha, and Cox-2) and upregulated anti-inflammatory miRNAs (miR +exosome 34155579 hsa-mir-26a Reperfusion Injury I/R significantly up-regulated ABR threshold shift and promoted hair cell apoptosis indicated by parvalbumin and caspase-3 staining, while CSGPC-exos (0.5 mug/mul, 1.0 mug/mul) could diminish such damages with downregulated proinflammatory factors (IL-6, IL-1beta, TNF-alpha, and Cox-2) and upregulated anti-inflammatory miRNAs (miR +exosome 34155579 hsa-mir-21 Reperfusion Injury I/R significantly up-regulated ABR threshold shift and promoted hair cell apoptosis indicated by parvalbumin and caspase-3 staining, while CSGPC-exos (0.5 mug/mul, 1.0 mug/mul) could diminish such damages with downregulated proinflammatory factors (IL-6, IL-1beta, TNF-alpha, and Cox-2) and upregulated anti-inflammatory miRNAs (miR +genetics_knock down_promote 34154607 hsa-mir-140 Arthritis, Rheumatoid CONCLUSION: CircMAPK9 knockdown might inhibit cell proliferation, migration, invasion, inflammatory response, and facilitate apoptosis in RA-FLSs via regulating miR +lncRNA target 34153672 hsa-mir-149 Osteoarthritis Circ_0008956 contributed to IL-1beta-induced growth arrest and ECM degradation in chondrocytes via miR5p/NAMPT axis, suggesting a new insight into the pathogenesis of OA and a promising therapeutic target for OA treatment. +exosome 34153644 hsa-mir-26b Endometrial Neoplasms Taken together, our study reveals that exosomal NEAT1 from CAFs contributes to EC progression via miR-26a/b-5p-mediated STAT3/YKL-40 pathway, which indicates the therapeutic potential of exosomal NEAT1 for treating EC. +exosome 34153644 hsa-mir-26a Endometrial Neoplasms Taken together, our study reveals that exosomal NEAT1 from CAFs contributes to EC progression via miR-26a/b-5p-mediated STAT3/YKL-40 pathway, which indicates the therapeutic potential of exosomal NEAT1 for treating EC. +genetics_overexpression_promote 34153339 hsa-mir-424 Glioblastoma miR-424 overexpression significantly suppressed cell proliferation and migration rate in glioblastoma cells based on the MTT and scratch assays. +genetics_overexpression_promote 34153312 hsa-mir-23b Alzheimer Disease Taken together, we conclude that overexpression of miR-23b can interrupt the pathogenesis of AD. +lncRNA target 34153299 hsa-mir-136 Carcinoma, Hepatocellular 5p/ILF2 axis plays a significant regulatory role in HCC progression, which may partly explain the pathogenic mechanisms of HCC and may provide promising potential targets for the diagnosis, treatment, and prognosis of HCC. +genetics_overexpression_promote 34153159 hsa-mir-485 Glioma 5p overexpression significantly reduced the growth of glioma xenografts and prolonged survival time. +other 34153004 hsa-mir-1231 Thyroid Cancer, Papillary Our consequence showed circKIF4A facilitated the malignant progress of papillary thyroid tumor by sponging miR-1231 and upregulating GPX4 expression. +lncRNA target 34152928 hsa-mir-326 Breast Neoplasms Conclusion: CircHIPK3 sponges miR-326 to promote BCa growth and metastasis. +circulation_biomarker_diagnosis_up 34152844 hsa-mir-126 Diabetic Nephropathies Diabetic nephropathy patients' plasma hsa-miR +circulation_biomarker_diagnosis_up 34152844 hsa-mir-200a Diabetic Nephropathies Diabetic nephropathy patients' plasma hsa-miR +circulation_biomarker_diagnosis_up 34152844 hsa-mir-2115 Diabetic Nephropathies Diabetic nephropathy patients' plasma hsa-miR +other 34152551 hsa-mir-3 Nervous System Diseases 3p in the context of neurological diseases. +genetics_GWAS 34152066 hsa-mir-17 Squamous Cell Carcinoma of Head and Neck CONCLUSION: Overall, LSD1 functions as a cancer stem cell supporter in OSCC by catalyzing demethylation of miR-17 and activating the downstream KPNA2/PI3K/AKT pathway, which contributes to understanding of the mechanisms associated with epigenetic regulation in OSCC. +circulation_biomarker_diagnosis_ns 34151771 hsa-mir-19b Asthma OBJECTIVE: This study aimed to investigate the expression level of free-circulating plasma microRNAs, hsa-miR-19b-3p, hsa-miR-125b-5p, and hsa-miR-320c in patients with BA, COPD and ACOS for the detection and validation of new microRNAs as biomarkers for chronic lung diseases. +circulation_biomarker_diagnosis_ns 34151771 hsa-mir-125b Asthma OBJECTIVE: This study aimed to investigate the expression level of free-circulating plasma microRNAs, hsa-miR-19b-3p, hsa-miR-125b-5p, and hsa-miR-320c in patients with BA, COPD and ACOS for the detection and validation of new microRNAs as biomarkers for chronic lung diseases. +circulation_biomarker_diagnosis_ns 34151771 hsa-mir-19b Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome OBJECTIVE: This study aimed to investigate the expression level of free-circulating plasma microRNAs, hsa-miR-19b-3p, hsa-miR-125b-5p, and hsa-miR-320c in patients with BA, COPD and ACOS for the detection and validation of new microRNAs as biomarkers for chronic lung diseases. +circulation_biomarker_diagnosis_ns 34151771 hsa-mir-19b Pulmonary Disease, Chronic Obstructive OBJECTIVE: This study aimed to investigate the expression level of free-circulating plasma microRNAs, hsa-miR-19b-3p, hsa-miR-125b-5p, and hsa-miR-320c in patients with BA, COPD and ACOS for the detection and validation of new microRNAs as biomarkers for chronic lung diseases. +circulation_biomarker_diagnosis_ns 34151771 hsa-mir-125b Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome OBJECTIVE: This study aimed to investigate the expression level of free-circulating plasma microRNAs, hsa-miR-19b-3p, hsa-miR-125b-5p, and hsa-miR-320c in patients with BA, COPD and ACOS for the detection and validation of new microRNAs as biomarkers for chronic lung diseases. +circulation_biomarker_diagnosis_up 34151771 hsa-mir-320c Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome hsa-miR-320c was downregulated in the blood plasma of patients with BA, and upregulated in patients with COPD and ACOS. +circulation_biomarker_diagnosis_up 34151771 hsa-mir-320c Pulmonary Disease, Chronic Obstructive hsa-miR-320c was downregulated in the blood plasma of patients with BA, and upregulated in patients with COPD and ACOS. +circulation_biomarker_diagnosis_up 34151771 hsa-mir-320c Asthma hsa-miR-320c was downregulated in the blood plasma of patients with BA, and upregulated in patients with COPD and ACOS. +circulation_biomarker_diagnosis_ns 34151771 hsa-mir-125b Pulmonary Disease, Chronic Obstructive OBJECTIVE: This study aimed to investigate the expression level of free-circulating plasma microRNAs, hsa-miR-19b-3p, hsa-miR-125b-5p, and hsa-miR-320c in patients with BA, COPD and ACOS for the detection and validation of new microRNAs as biomarkers for chronic lung diseases. +genetics_knock down_suppress 34151707 hsa-mir-211 Spinal Cord Injuries Taken together, the knockdown of NEAT1 remarkably alleviated the inflammation of SCI via miR5p/MAPK1 axis. +circRNA target 34151690 hsa-mir-146b Drug-Related Side Effects and Adverse Reactions CircTMOD3 regulated LPS-induced cell inflammation and injury by targeting miR-146b-3p, and miR-146b-3p-mediated suppression of CXCR1 impacted LPS-evoked cytotoxicity and inflammation. +circRNA target 34151690 hsa-mir-146b Inflammation CircTMOD3 regulated LPS-induced cell inflammation and injury by targeting miR-146b-3p, and miR-146b-3p-mediated suppression of CXCR1 impacted LPS-evoked cytotoxicity and inflammation. Conclusion: Our findings demonstrated the regulation of circTMOD3 in LPS-induced cell injury and inflammation at least partially via miR-146b-3p-independent modulation of CXCR1. +genetics_knock down_promote 34151668 hsa-mir-223 Inflammatory Bowel Diseases Besides, inhibition of NF-kappaB signalling attenuated the pyroptosis-promoting effect of overexpressing miR-223.Our data suggested that miR-223 activated the NF-kappaB pathway via targeting SNIP1, thus promoting the process of cell pyroptosis, and ultimately participating in the pathogenesis of IBD. +lncRNA target 34151476 hsa-mir-524 Osteosarcoma circITCH sponged miR-524 to up-regulate RASSF6, causing OS progression inhibition and DXR resistance reduction. +target gene 34150620 hsa-let-7a Stomach Neoplasms Chrysin Induced Cell Apoptosis Through H19/let-7a/COPB2 Axis in Gastric Cancer Cells and Inhibited Tumor Growth. +genetics_knock down_suppress 34150336 hsa-mir-194 Glioma Animal experiments suggested that circ_0030018 knockdown could reduce glioma tumor growth through regulating miR +lncRNA target 34150180 hsa-mir-744 Glioma Functional experiments showed that the inhibition of LINC01116 could up-regulate miR +circulation_biomarker_diagnosis_ns 34150128 hsa-mir-192 Multiple Myeloma OBJECTIVE: To investigate the expression level of serum miRNA5p and its clinical value in the diagnosis and care of patients with multiple myeloma (MM). +other 34150094 hsa-mir-93 Carcinoma, Non-Small-Cell Lung 5p and miR-18a is associated with NSCLC severity and prognosis, and both can be used as potential markers for diagnosis. +other 34150094 hsa-mir-18a Carcinoma, Non-Small-Cell Lung 5p and miR-18a is associated with NSCLC severity and prognosis, and both can be used as potential markers for diagnosis. +target gene 34150070 hsa-mir-1307 Osteosarcoma DEX can effectively inhibit the proliferation, invasion, metastasis, and apoptosis of osteosarcoma cells in a dose-dependent manner, and its efficacy may be related to its regulation of miR-1307 expression. +other 34150061 hsa-mir-223 Coronary Disease 3p and NRF2 can be predictors of clinical efficacy. +transcription factor target 34150047 hsa-mir-335 Pre-Eclampsia OBJECTIVE: To investigate the role of miRNA-335 on the proliferation and apoptosis of placental trophoblast cells in preeclamptic rats and its potential mechanism. CONCLUSION: miRNA-335 inhibition can enhance the expression of CRIM1 to promote the proliferation and reduce the apoptosis of trophoblast cells in preeclamptic rats. +other 34150044 hsa-mir-223 Alzheimer Disease METHODS: SH-SY5Y cells were treated with Abeta 25-35 to simulate nerve injury in the pathogenesis of Alzheimer's disease (AD), and JAT-treated SH-SY5Y cells were assessed for HDAC4 and miR3p. +exosome 34150009 hsa-mir-153 Osteosarcoma CONCLUSION: Highly enriched exosomal lncRNA OIP5-AS1 can regulate OS tumor angiogenesis and autophagy through miR-153 and ATG5. +exosome 34150007 hsa-mir-18a Hirschsprung-Associated Enterocolitis Collectively, exosomal miR-18a-5p was a promoter of HAEC, which induces the intestine cell apoptosis and inflammatory responses through the inhibition of SIRT1/NFkappaB pathway by targeting RORA. +exosome 34150007 hsa-mir-18a Inflammatory Bowel Diseases Collectively, exosomal miR-18a-5p was a promoter of HAEC, which induces the intestine cell apoptosis and inflammatory responses through the inhibition of SIRT1/NFkappaB pathway by targeting RORA. +target gene 34150003 hsa-mir-142 Breast Neoplasms Circular RNA circ_0084927 regulates proliferation, apoptosis, and invasion of breast cancer cells via miR-142-3p/ERC1 pathway. +genetics_knock down_promote 34149934 hsa-mir-455 Cholangiocarcinoma In support, overexpression of miR +circulation_biomarker_diagnosis_up 34149922 hsa-mir-223 Carcinoma, Hepatocellular 3p, miR-26a-5p, and miR-30c-5p were significantly down-regulated in the plasma of HCC samples, while miR-365a-3p and miR +circulation_biomarker_diagnosis_up 34149922 hsa-mir-423 Carcinoma, Hepatocellular 3p, miR-26a-5p, and miR-30c-5p were significantly down-regulated in the plasma of HCC samples, while miR-365a-3p and miR +circulation_biomarker_diagnosis_up 34149922 hsa-mir-365a Carcinoma, Hepatocellular 3p, miR-26a-5p, and miR-30c-5p were significantly down-regulated in the plasma of HCC samples, while miR-365a-3p and miR +circulation_biomarker_diagnosis_up 34149922 hsa-mir-26a Carcinoma, Hepatocellular 3p, miR-26a-5p, and miR-30c-5p were significantly down-regulated in the plasma of HCC samples, while miR-365a-3p and miR +target gene 34149919 hsa-mir-615 Uterine Cervical Neoplasms Upregulation of LINC01503 promotes cervical cancer progression by targeting the miR-615-3p/CCND1 axis. +other 34149906 hsa-mir-27a Stomach Neoplasms 5p, may serve critical roles in EGC. +other 34149906 hsa-let-7a Stomach Neoplasms 5p, may serve critical roles in EGC. +other 34149906 hsa-mir-126 Stomach Neoplasms 5p, may serve critical roles in EGC. +other 34149906 hsa-mir-424 Stomach Neoplasms 5p, may serve critical roles in EGC. +other 34149904 hsa-mir-182 Breast Neoplasms The results revealed that the expression levels of miR5p, PD-L1 and metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) were upregulated in MDA-MB-231 cells and BC tissues. +transcription factor target 34149902 hsa-mir-4491 Carcinoma, Non-Small-Cell Lung In addition, TRIM7 silencing attenuated the effect of miR-4491 inhibitor in NSCLC cells. +other 34149892 hsa-mir-20a Lung Neoplasms Upregulated osteoprotegerin expression promotes lung cancer cell invasion by increasing miR-20a expression. +other 34149890 hsa-mir-200a Ischemic Stroke Collectively, the present results suggested that LINC00319 promoted apoptosis and aggravated neuronal injury induced by OGD by regulating miR-200a-3p, which may be important for ischemic stroke treatment. +lncRNA target 34149889 hsa-mir-24 Burns 5p and targeting CDK16 in the HDFs after thermal injury, implying a protective role for TPT1-AS1 in the burn wound healing process. +other 34149884 hsa-mir-125b Acquired Immunodeficiency Syndrome The expression of miR-125b-5p and ASCT2 mRNA was detected in colon biopsy samples of 10 patients with AIDS and 10 control healthy subjects. The results demonstrated that miR-125b-5p levels were increased and ASCT2 mRNA expression levels were decreased in colon samples from patients with AIDS and in LPS-induced intestinal mucosa cells. +circulation_biomarker_diagnosis_ns 34149877 hsa-mir-200b Angelman Syndrome Furthermore, miR-200b-3p expression was negatively correlated with ABCA1 expression in the blood of the patients with As. +other 34149871 hsa-mir-155 Diabetic Neuropathies The present study demonstrated the involvement of the miR-155/COX-2 axis in the protective effect of CXB against high glucose-induced DN. +transcription factor target 34149870 hsa-mir-133a Gastrointestinal Diseases These results suggested that miR-133a-3p may be a promising therapeutic target for the diagnosis and treatment of gut-origin sepsis. +transcription factor target 34149870 hsa-mir-133a Sepsis These results suggested that miR-133a-3p may be a promising therapeutic target for the diagnosis and treatment of gut-origin sepsis. +other 34149807 hsa-mir-126 Adenocarcinoma of Lung 5p/TEK as immune-related ceRNA networks in LUAD progression. +other 34149807 hsa-mir-21 Adenocarcinoma of Lung 5p/TEK as immune-related ceRNA networks in LUAD progression. +transcription factor target 34149802 hsa-mir-196a Parkinson Disease The study of miRNA-target genes highlighted a possible role of miR-499a, miR-196a2, and miR-29a in the modulation of multiple neuroinflammatory and neurodegenerative mechanisms underlying PD physiopathology. +transcription factor target 34149802 hsa-mir-499a Parkinson Disease The study of miRNA-target genes highlighted a possible role of miR-499a, miR-196a2, and miR-29a in the modulation of multiple neuroinflammatory and neurodegenerative mechanisms underlying PD physiopathology. +transcription factor target 34149802 hsa-mir-29a Parkinson Disease The study of miRNA-target genes highlighted a possible role of miR-499a, miR-196a2, and miR-29a in the modulation of multiple neuroinflammatory and neurodegenerative mechanisms underlying PD physiopathology. +genetics_overexpression_suppress 34149728 hsa-mir-145 Sjogren's Syndrome 5p modulates MUC1 and TLR4 overexpression in SG from SS-patients in a type I IFN dependent manner. +lncRNA target 34149433 hsa-mir-10a Osteoarthritis, Knee The results showed that miR-10a-3p can recover the OA features through targeting CH25H/CYP7B1/RORalpha axis. +lncRNA target 34149433 hsa-mir-10a Cartilage Diseases The results showed that miR-10a-3p can recover the OA features through targeting CH25H/CYP7B1/RORalpha axis. +other 34149424 hsa-mir-199a Death, Sudden Furthermore, although this investigation was not designed to characterize the safety of transplanted AAV6-miR-199a-transduced hiPSC-CMs, there was no evidence of sudden death. +other 34149424 hsa-mir-199a Heart Diseases microRNAs are key regulators of cardiomyocyte proliferation, and when adeno-associated viruses coding for microRNA-199a (miR-199a) expression were injected directly into infarcted pig hearts, measures of cardiac function and fibrosis significantly improved, but the treatment was also associated with lethal arrhythmia. +lncRNA target 34149180 hsa-mir-183 Thyroid Cancer, Papillary 5p directly targeted PPP2R2A, and promoted PTC progression through regulating PPP2R2A. +other 34149178 hsa-mir-582 Glioma LncRNA-NNT-AS1 contributes to the progression of glioma by miR-582-5p/EZH2 axis. +lncRNA target 34149174 hsa-mir-379 Stomach Neoplasms 5p, indicating that LINC00665 might be a potential therapeutic target for DDP- resistant GC patients. +target gene 34149172 hsa-mir-4735 Ovarian Neoplasms LncRNA ARAP1-AS1 aggravates the malignant phenotypes of ovarian cancer cells through sponging miR-4735-3p to enhance PLAGL2 expression. +lncRNA target 34148561 hsa-mir-206 Polycystic Ovary Syndrome CONCLUSIONS: Highly expressed lncROR indirectly up-regulated the expression of VEGF by down-regulating the expression of miR-206, thereby promoting the proliferation of KGN cells and inhibiting apoptosis, and further promoting the development of PCOS. +other 34148372 hsa-mir-501 Breast Neoplasms LncRNA-miRNA-mRNA network highlighted a potential mechanism of BCBM in which lncRNA FIRRE and RP11-169F17.1 sponging hsa-miR5p to regulate the expression of MMS19, PTBP1 and NUP98. +genetics_overexpression_promote 34148288 hsa-mir-375 Carcinoma, Hepatocellular The transfection of circ_0072088 overexpression plasmid or miR-375 inhibitors promoted the proliferation, migration, and invasion, and inhibited the apoptosis of HCC cells, whereas transfection of circ_0072088 siRNA or miR-375 mimics exerted opposite effects. +other 34148185 hsa-mir-421 Carcinoma, Hepatocellular Our data suggest that Tregs, CD4 T cells, mast cells, SNHG1, HMMR and hsa-miR-421 are associated with HCC based on ceRNA immune cells co-expression patterns. +lncRNA target 34148029 hsa-mir-29b Carcinoma, Hepatocellular Moreover, miR-29b-3p has been identified as a negatively regulatory target gene of HCP5, and served as a tumor suppressor of HCC to prevent cell proliferation, migration, and invasion. +lncRNA target 34147937 hsa-mir-508 Precursor Cell Lymphoblastic Leukemia-Lymphoma 5p were nominated from a list of putative miRNAs targeting ABCA3. +genetics_knock down_promote 34147851 hsa-mir-934 Breast Neoplasms However, miR-934 knockdown significantly inhibited the migration and invasion abilities of BC cells. +circRNA target 34147657 hsa-mir-556 Angelman Syndrome Thus, we came a conclusion that circDIP2C protected against ox-LDL-induced HUVEC damage by upregulating TET2 expression through sponging miR5p, which provided a strategy for the therapy of AS. +lncRNA target 34147470 hsa-mir-433 Glioma 3p inhibits the malignant progression of glioma by targeting and down-regulating the expression of SMC4. +exosome 34147083 hsa-mir-203a Colorectal Neoplasms COCLUSION: MiR-203a-3p derived from hepatocyte exosomes plays an important role of CRC cells to colonize in liver. +transcription factor target 34147072 hsa-mir-206 Osteoarthritis CONCLUSION: MiR-206 contributed to the progression of OA by modulating Th17/Treg imbalance, suggesting that miR-206 inhibition might be a promising therapeutic strategy for the treatment of OA. +genetics_overexpression_promote 34146927 hsa-mir-146a Periodontitis Overexpression of microRNA-146a inhibited proliferation of PDLSCs derived from both periodontitis-affected teeth and healthy teeth while downregulating IL-13. +lncRNA target 34146302 hsa-mir-124 Myocardial Infarction, Acute 3p expression may activate the FGF21/CREB/PGC1alpha pathway to reduce cell apoptosis, alleviate the inflammatory response, and attenuate oxidative stress in AMI rats by targeting SIRT1. +virus_miRNA 34146250 ebv-mir-BART11 stomach carcinoma Eukaryotic initiating factor eIF4E is targeted by EBV-encoded miR-BART11-3p and regulates cell cycle and apoptosis in EBV-associated gastric carcinoma +other 34146198 hsa-mir-3 Diabetes Mellitus These findings support the possible role of miR-33 to monitor pre-diabetes onset and progression. +exosome 34146092 hsa-mir-21 Keloid Here, we extracted exosomes from the culture supernatants of keloid and normal skin fibroblasts and observed that both types of cells above secrete exosomes; however, keloid fibroblasts secreted significantly more exosomal miR-21 than normal skin fibroblasts (P < .001). +genetics_overexpression_suppress 34145797 hsa-mir-199b Endometrial Neoplasms MiR-199b-5p inhibitors or SLC7A5 overexpression attenuated circZNF124 silencing-mediated EC malignant progression. +other 34145485 hsa-mir-142 Norrie disease The finding might provide novel insight into the role of miR3p/BOD1 axis in DN treatment. +genetics_overexpression_promote 34145425 hsa-mir-181c Ovarian Neoplasms Overexpression of miR-181c sensitized resistant OC to PTX by inhibiting the PI3K/Akt pathway in vitro and in vivo. +lncRNA target 34145399 hsa-mir-17 Colorectal Neoplasms In conclusion, the present study indicates that the lactate-responsive lncRNA MIR17HG, acting as a ceRNA, promotes CRLM through a glycolysis-mediated positive feedback circuit and might be a novel biomarker and therapeutic target for CRLM. +circulation_biomarker_diagnosis_ns 34144376 hsa-mir-346 Tuberculosis The mean serum log hsa-miR-346 levels were -15.48 (-15.76 to -15.21) in patients with tuberculosis and -16.12 (-16.29 to -15.95) in healthy volunteers, which significantly differed. +lncRNA target 34144190 hsa-mir-139 Myocardial Infarction, Acute 5p inhibits endothelial cell viability of AMI by inhibiting VEGFR-1, and increased miR +transcription factor target 34143694 hsa-mir-145 Hyperlipidemias In conclusion, MiR5p modulated lipid metabolism and M2 macrophage polarization by targeting PAK7 and regulating beta-catenin signaling in hyperlipidemia, which may provide a potential biomarker for the treatment of hyperlipidemia-induced cardiovascular diseases. +epigenetics 34143366 hsa-mir-181a Thyroid Cancer, Papillary KDM5C was identified as the target gene of miR-181a and represses S100A2 expression through histone demethylation to diminish the migration and proliferation of PTC cells. +lncRNA target 34143347 hsa-mir-135a Asthma In conclusion, SB inhibited NLRP3 inflammasome activation and reduced pyroptosis via the miR-135a-5p/TRPC1/STAT3/NF-kappaB axis, thus alleviating airway inflammation and airway remodeling in asthma. +lncRNA target 34143347 hsa-mir-135a Pneumonia In conclusion, SB inhibited NLRP3 inflammasome activation and reduced pyroptosis via the miR-135a-5p/TRPC1/STAT3/NF-kappaB axis, thus alleviating airway inflammation and airway remodeling in asthma. +circRNA target 34143288 hsa-mir-127 Carcinoma, Squamous Cell, Cutaneous Hsa_circ_0008234 facilitates the proliferation of cSCC through targeting miR +other 34142698 hsa-mir-139 Diabetes Mellitus High fatty acid reduces insulin secretion in pancreatic beta-cells and miR5p is increased in diabetic pancreatic tissues and induces islet beta-cell apoptosis. +lncRNA target 34142340 hsa-mir-448 Prostatic Neoplasms CONCLUSIONS: Our research shows that circHIPK3 plays a carcinogenic effect in PCa by regulating the miR-448/MTDH axis, indicating that circHIPK3 may be a potential therapeutic target for PCa. +circulation_biomarker_prognosis_ns 34141710 hsa-mir-2276 Glioma 5p is significantly reduced in the plasma of glioma patients, and thus, it could be a potential biomarker for patients with glioma for diagnostic and/or prognostic purposes. +other 34141614 hsa-mir-204 Thyroid Neoplasms In summary, our study found a potential mechanism in which hsa-miR5p regulated ALPL in activated dendritic cells, which may allow them to play a critical role in thyroid carcinoma. +other 34141611 hsa-mir-16-1 Osteosarcoma Silencing of the Long Non-Coding RNA TTN-AS1 Attenuates the Malignant Progression of Osteosarcoma Cells by Regulating the miR-16-1-3p/TFAP4 Axis. +lncRNA target 34141179 hsa-mir-26a Aortic Aneurysm, Abdominal In short, CurTn suppressed VSMCs pyroptosis and inflammation though mediation PVT1/miR-26a/KLF4 axis by regulating the PI3K/AKT signaling pathway, CurTn might consider as a potential therapeutic target in the treatment of AAA. +lncRNA target 34141159 hsa-mir-146a Drug-Induced Kidney Injury This nephrotoxicity mediated by upregulation of the messenger RNA (mRNA) gene expression of the autophagy markers: Beclin-1, microtubule-associated protein LC3, p62 binding protein, immunoglobulin G receptor Fcgamma receptor (FcgammaR), micro-RNA-1 (miR-1), protein expression of phospho-adenosine monophosphate-activated protein kinase, and phospho-mammalian target of rapamycin, along with downregulation of miR-146a mRNA gene expression and alteration of calcium and iron levels. +lncRNA target 34141159 hsa-mir-1 Drug-Induced Kidney Injury This nephrotoxicity mediated by upregulation of the messenger RNA (mRNA) gene expression of the autophagy markers: Beclin-1, microtubule-associated protein LC3, p62 binding protein, immunoglobulin G receptor Fcgamma receptor (FcgammaR), micro-RNA-1 (miR-1), protein expression of phospho-adenosine monophosphate-activated protein kinase, and phospho-mammalian target of rapamycin, along with downregulation of miR-146a mRNA gene expression and alteration of calcium and iron levels. +genetics_GWAS 34141156 hsa-mir-124 Neural Tube Defects MiR-124 down-regulation may occur via epigenetic mechanisms and contribute to HCY-induced NTDs in chick embryo models. +genetics_knock down_suppress 34140798 hsa-mir-31 Inflammatory Bowel Diseases CONCLUSION: Our data determined that UCA1 knockdown attenuated UC development via targeting the miR +other 34140779 hsa-mir-210 Lung Neoplasms miR-210-3p Promotes Lung Cancer Development and Progression by Modulating USF1 and PCGF3. +circulation_biomarker_diagnosis_up 34140641 hsa-mir-135b Colorectal Neoplasms And miR-135b-5p was increased in the serum of colorectal cancer patients. +circulation_biomarker_diagnosis_ns 34140396 hsa-mir-1287 Diabetes Mellitus RESULTS: In the late diabetic kidney disease cohorts, we identified 17 circulating miRNAs, represented by four exemplars (miR +circulation_biomarker_diagnosis_ns 34140396 hsa-mir-197 Diabetic Nephropathies RESULTS: In the late diabetic kidney disease cohorts, we identified 17 circulating miRNAs, represented by four exemplars (miR +circulation_biomarker_diagnosis_ns 34140396 hsa-mir-1287 Diabetic Nephropathies RESULTS: In the late diabetic kidney disease cohorts, we identified 17 circulating miRNAs, represented by four exemplars (miR +circulation_biomarker_diagnosis_ns 34140396 hsa-mir-197 Diabetes Mellitus RESULTS: In the late diabetic kidney disease cohorts, we identified 17 circulating miRNAs, represented by four exemplars (miR +circulation_biomarker_diagnosis_ns 34140396 hsa-mir-28 Diabetes Mellitus RESULTS: In the late diabetic kidney disease cohorts, we identified 17 circulating miRNAs, represented by four exemplars (miR +circulation_biomarker_diagnosis_ns 34140396 hsa-mir-28 Diabetic Nephropathies RESULTS: In the late diabetic kidney disease cohorts, we identified 17 circulating miRNAs, represented by four exemplars (miR +genetics_overexpression_promote 34140036 hsa-mir-337 Osteoarthritis 3p overexpression-mediated facilitation in viability, and inhibition in apoptosis, TNF-alpha and IL-6 generation and ECM degradation in OA model cells. +genetics_knock down_promote 34140005 hsa-mir-149 Esophageal Squamous Cell Carcinoma The overexpression of MEG3, p53 or miR +transcription factor target 34139980 hsa-mir-1 Adenocarcinoma of Lung 3p could suppress the malignant phenotypes of LUAD cells by targeting CELSR3, which will help to provide novel therapeutic strategies for LUAD sufferers and new references for the targeted therapy of LUAD. +lncRNA target 34139933 hsa-mir-378b Carcinoma, Hepatocellular Circ_0078710 interference-induced effects in curcumin-stimulated HCC cells were partly abolished by the silence of miR-378b. CONCLUSIONS: Circ_0078710 silencing aggravated curcumin-mediated anti-tumor effects through mediating the miR-378b/PRIM2 signaling in HCC cells. +genetics_overexpression_promote 34139744 hsa-mir-532 Myocardial Infarction ACAP2 is overexpressed in MI and may promote the maturation of miR-532 to induce the apoptosis of cardiomyocyte. +genetics_knock down_suppress 34139630 hsa-mir-193 Endometritis In conclusion, our study firstly reported the mechanism by which miR-193a-3p targets LGR4 to elevate the inflammatory response in bovine endometrium injury, thereby implying that knockdown miR-193a-3p may lay the theoretical and practical basis for drug development of alleviating endometritis in dairy cows. +genetics_knock down_suppress 34139630 hsa-mir-193a Endometritis In conclusion, our study firstly reported the mechanism by which miR-193a-3p targets LGR4 to elevate the inflammatory response in bovine endometrium injury, thereby implying that knockdown miR-193a-3p may lay the theoretical and practical basis for drug development of alleviating endometritis in dairy cows. +transcription factor target 34139323 hsa-mir-467b Non-alcoholic Fatty Liver Disease This suggests that targeting of the HNF4alpha/miR-467b-3p/GPAT1 cascade may be used as a potential therapeutic strategy to control NAFLD. +transcription factor target 34139319 hsa-mir-125a Liver Injury Dysregulation of miR-125a-5p might be a possible mechanism of isoflurane-induced liver injury. +lncRNA target 34138419 hsa-mir-93 Kidney Failure, Chronic CONCLUSION: MiR-93, via inhibiting the activity of Wnt/beta-catenin pathway by targeting TCF4, can improve the renal function of CRF rats, thereby mitigating the vascular calcification of CRF. +genetics_knock down_promote 34138410 hsa-mir-100 Cardiomegaly Knockdown of miR +genetics_overexpression_suppress 34137496 hsa-mir-126 Scleroderma, Systemic Inhibition of miR-126 in NL-MVECs resulted in reduced angiogenic capacity, whereas overexpression of miR-126 in SSc-MVECs resulted in enhanced tube assembly. +other 34137440 hsa-mir-210 Hypoxia Furthermore, we found that coilin is needed for the hypoxic induction of a well-known hypoxia-induced miRNA (hypoxamiR), miR-210, as well as for the hypoxia-induced alternative splicing of the miR-210 host gene, MIR210HG. +other 34137197 hsa-mir-624 Duane Retraction Syndrome 3p in human retinal endothelial cells. +circRNA target 34136582 hsa-mir-296 Uterine Cervical Neoplasms 5p/HMGA1 pathway may be a potential target for the treatment of cervical cancer. +other 34136547 hsa-mir-155 Death, Sudden, Cardiac miR-155 is one of the best characterized miRNAs and plays a critical role in several physiological and pathological process, including cardiovascular diseases. +genetics_overexpression_promote 34136482 hsa-mir-92b Small Cell Lung Carcinoma Importantly, exosomes isolated from the conditioned medium of SBC-3 cells overexpressing miR-92b-3p could promote SCLC chemoresistance and cell migration. +circRNA target 34136401 hsa-mir-141 Adenocarcinoma of Lung Our findings suggest that circKEAP1 inhibits LUAD progression through circKEAP1/miR +target gene 34135963 hsa-mir-455 Carcinoma, Hepatocellular miR-455 Inhibits the Viability and Invasion by Targeting RAB18 in Hepatocellular Carcinoma. +other 34135940 hsa-mir-148a Colorectal Neoplasms Hypoxia-Induced miR-148a Downregulation Contributes to Poor Survival in Colorectal Cancer. +other 34135841 hsa-mir-6810 Macular Degeneration In addition, the bioinformatic analysis of the associated miRNA variants highlighted miR-196a, miR-6796, miR-6499, miR-6810, miR-499, and miR-7854 as potential candidates for counteracting AMD and neurodegenerative processes. +other 34135841 hsa-mir-196a Macular Degeneration In addition, the bioinformatic analysis of the associated miRNA variants highlighted miR-196a, miR-6796, miR-6499, miR-6810, miR-499, and miR-7854 as potential candidates for counteracting AMD and neurodegenerative processes. +other 34135841 hsa-mir-6499 Macular Degeneration In addition, the bioinformatic analysis of the associated miRNA variants highlighted miR-196a, miR-6796, miR-6499, miR-6810, miR-499, and miR-7854 as potential candidates for counteracting AMD and neurodegenerative processes. +other 34135841 hsa-mir-7854 Macular Degeneration In addition, the bioinformatic analysis of the associated miRNA variants highlighted miR-196a, miR-6796, miR-6499, miR-6810, miR-499, and miR-7854 as potential candidates for counteracting AMD and neurodegenerative processes. +other 34135841 hsa-mir-6499 Neurodegenerative Diseases In addition, the bioinformatic analysis of the associated miRNA variants highlighted miR-196a, miR-6796, miR-6499, miR-6810, miR-499, and miR-7854 as potential candidates for counteracting AMD and neurodegenerative processes. +other 34135841 hsa-mir-6796 Macular Degeneration In addition, the bioinformatic analysis of the associated miRNA variants highlighted miR-196a, miR-6796, miR-6499, miR-6810, miR-499, and miR-7854 as potential candidates for counteracting AMD and neurodegenerative processes. +other 34135841 hsa-mir-7854 Neurodegenerative Diseases In addition, the bioinformatic analysis of the associated miRNA variants highlighted miR-196a, miR-6796, miR-6499, miR-6810, miR-499, and miR-7854 as potential candidates for counteracting AMD and neurodegenerative processes. +other 34135841 hsa-mir-6810 Neurodegenerative Diseases In addition, the bioinformatic analysis of the associated miRNA variants highlighted miR-196a, miR-6796, miR-6499, miR-6810, miR-499, and miR-7854 as potential candidates for counteracting AMD and neurodegenerative processes. +other 34135841 hsa-mir-196a Neurodegenerative Diseases In addition, the bioinformatic analysis of the associated miRNA variants highlighted miR-196a, miR-6796, miR-6499, miR-6810, miR-499, and miR-7854 as potential candidates for counteracting AMD and neurodegenerative processes. +other 34135841 hsa-mir-6796 Neurodegenerative Diseases In addition, the bioinformatic analysis of the associated miRNA variants highlighted miR-196a, miR-6796, miR-6499, miR-6810, miR-499, and miR-7854 as potential candidates for counteracting AMD and neurodegenerative processes. +other 34135769 hsa-mir-223 Vasculitis In conclusion, septic platelets released PMPs carrying functional miR-223 lower ICAM1 expression in endothelial cells, which may be a protective role against excessive sepsis-induced vascular inflammation. +other 34135670 hsa-mir-191 Triple Negative Breast Neoplasms This study demonstrates that miR-191 liposomes may have promising clinical applications for TNBC therapy. +genetics_overexpression_suppress 34135635 hsa-mir-613 Esophageal Squamous Cell Carcinoma In ESCC cells, CircRIMS overexpression decreased the expression of miR-613 and increased the methylation of miR-613 gene. +other 34135620 hsa-mir-28 Reperfusion Injury, Cerebral Ischemia 3p aggravated cerebral I/R injury. +other 34135620 hsa-mir-28 Stroke 3p aggravated cerebral I/R injury. +lncRNA target 34135616 hsa-mir-148b Myocardial Infarction CONCLUSION: This study demonstrated for the first time the important mechanism of action of the NEAT1/miR-148b-3p/ICAM-1 axis in the progression of CSF disease, and indicated the potential of NEAT1, miR-148b-3p, and ICAM-1 as a new target for the diagnosis and treatment of CSF. +target gene 34135597 hsa-mir-326 Breast Neoplasms circHIPK3 (hsa_circ_0000284) Promotes Proliferation, Migration and Invasion of Breast Cancer Cells via miR-326. +other 34135596 hsa-mir-942 Adenocarcinoma of Lung 5p), and the DEGs (IGF2BP3, MKI67, CD79A, and ABAT) may serve as prognostic markers in LUAD. +other 34135596 hsa-mir-532 Adenocarcinoma of Lung 5p), and the DEGs (IGF2BP3, MKI67, CD79A, and ABAT) may serve as prognostic markers in LUAD. +genetics_overexpression_promote 34135394 hsa-mir-520g Carcinoma, Hepatocellular Furthermore, overexpression of p53-R175H and p53-R273H mutants promote miR-520G and MAGEA RNA expression and cellular transformation. +circulation_biomarker_diagnosis_ns 34134962 hsa-mir-16 Ovarian Neoplasms The miR-16/polypeptide nanoparticles could be efficiently absorbed by human ovarian cancer cells and were distributed in the cytoplasm. +other 34134782 hsa-mir-152 Breast Neoplasms 3p could be considered a promising regulator of BC chemoresistance. +genetics_overexpression_promote 34134765 hsa-mir-20a Osteoporosis In this study, we intended to determine whether sEVs overexpressing miR-20a could exert a superior effect on osteoporotic bone defects and the underlying mechanism. +circulation_biomarker_diagnosis_up 34134589 hsa-mir-574 Sepsis Thus, serum miR +circulation_biomarker_diagnosis_up 34134589 hsa-mir-574 Acute Kidney Injury Thus, serum miR +other 34134471 hsa-mir-99a Leukemia, Myeloid, Acute Interestingly, upregulation of MIR99AHG and deregulation of the miRNA cluster, residing in the MIR99AHG locus, are known mechanisms of leukemogenesis in acute megakaryoblastic leukemia. +circulation_biomarker_diagnosis_up 34134454 hsa-mir-125a Arthritis, Rheumatoid 3p, and miR-125a-5p in the plasma of RA patients and compare them with those of healthy controls to obtain a specific expression profile for earlier diagnosis and assistance in treating patients. +circulation_biomarker_diagnosis_up 34134454 hsa-mir-24 Arthritis, Rheumatoid 3p, and miR-125a-5p in the plasma of RA patients and compare them with those of healthy controls to obtain a specific expression profile for earlier diagnosis and assistance in treating patients. +circulation_biomarker_diagnosis_up 34134454 hsa-mir-146a Arthritis, Rheumatoid 3p, and miR-125a-5p in the plasma of RA patients and compare them with those of healthy controls to obtain a specific expression profile for earlier diagnosis and assistance in treating patients. +other 34134453 hsa-mir-25 Multiple Sclerosis Our results indicate that miR3p expression is likely induced by inflammatory mediators during autoimmune neuroinflammation. +genetics_GWAS 34134452 hsa-mir-124 Arthritis, Rheumatoid Our findings propose a considerable association between rs531564 polymorphism in the pri-miR-124 gene with susceptibility and clinical characteristics of RA and SLE in the Iranian population. +genetics_GWAS 34134452 hsa-mir-124 Lupus Erythematosus, Systemic Our findings propose a considerable association between rs531564 polymorphism in the pri-miR-124 gene with susceptibility and clinical characteristics of RA and SLE in the Iranian population. +lncRNA target 34133012 hsa-mir-145 Spinal Cord Injuries 5p inhibition mitigates inflammation and oxidative stress via targeting Nurr1 to regulate TNF-alpha signaling, which ameliorates SCI. +genetics_overexpression_suppress 34133001 hsa-mir-377 Osteosarcoma 3p overexpression in vivo. +genetics_knock down_suppress 34132956 hsa-mir-122 Ovarian Neoplasms 5p overexpression inhibited the progression of OC cells by targeting SLC1A5. +circulation_biomarker_diagnosis_ns 34132944 hsa-mir-25 Colorectal Neoplasms Herein, we aim to evaluate the diagnostic potentials of plasma microRNA-211 and microRNA-25 in colorectal cancer patients. MicroRNA-211 and microRNA-25 might have a tumorigenic role in colorectal cancer and their plasma levels could be potential biomarkers in its diagnosis. +genetics_overexpression_promote 34132932 hsa-mir-129 Glioblastoma 5p overexpression inhibited GBM cell chemoresistance to TMZ and proliferation, and promoted cell apoptosis. +lncRNA target 34132637 hsa-mir-21 Gynatresia 5 p to inhibit miR +circulation_biomarker_diagnosis_down 34132380 hsa-mir-193a Carcinoma, Ovarian Epithelial The results indicated that the expression levels of miR193a5p were significantly decreased in serum samples obtained from patients with EOC and EOC cell lines compared with healthy individuals and normal cells, respectively. +genetics_overexpression_suppress 34132375 hsa-mir-431 Carcinoma, Ovarian Epithelial Mechanistically, LINC01132 acted as a competing endogenous RNA by sequestering miR4315p and consequently overexpressing SOX9 in EOC cells, forming a LINC01132/miR4315p/SOX9 axis. +genetics_knock down_suppress 34132371 hsa-mir-429 Squamous Cell Carcinoma of Head and Neck The present study examined the biological function of miR429 by performing the gain/lossoffunction studies of miR429 in a gingival squamous cell carcinoma line Ca922 cells that either over or underexpressed miR429 through transient transfection with miR429 mimic or miR429 inhibitor, respectively. +lncRNA target 34132371 hsa-mir-429 Mouth Diseases Taken together, the findings revealed the molecular mechanism of miR429 to regulate the inflammatory mediator in gingival cells and suggested that it could be useful as a therapeutic target of oral inflammatory diseases. +other 34132362 hsa-mir-375 Liver Neoplasms Furthermore, it was identified that increased mRNA stability was the primary reason for the upregulation of YAP expression in LC/CDDP cells, which was due to the downregulation of microRNA (miR)375 expression in LC/CDDP cells. In conclusion, the findings of the present study suggested that the miR375/YAP axis may regulate the expression levels of IL6 and TGFbeta, which may subsequently be involved in the CDDP resistance of LC cells. +genetics_knock down_promote 34132358 hsa-mir-16 Urinary Bladder Neoplasms Furthermore, it was found that blockade of the BIMP1/NFkappaB signaling pathway inversed the inhibitory effects of miR165p knockdown on autophagy in BC cells. +genetics_knock down_promote 34132358 hsa-mir-16 bladder urothelial carcinoma Furthermore, it was found that blockade of the BIMP1/NFkappaB signaling pathway inversed the inhibitory effects of miR165p knockdown on autophagy in BC cells. +circulation_biomarker_diagnosis_up 34132029 hsa-mir-199a Aortic Aneurysm, Abdominal The level of miR-199a-5p expression was upregulated in the plasma from AAA patients and Ang II-treated VSMCs. +genetics_overexpression_promote 34131397 hsa-mir-135b Stomach Neoplasms The in vitro functional assays demonstrated overexpression of miR-135b promoted cell proliferation, migration and invasion in GC, while miR-135b inhibition led to the opposite results. +other 34131232 hsa-mir-135b Incontinentia Pigmenti Among them, miR5p and miR-135b-5p were significantly downregulated by IPC. +other 34131232 hsa-mir-3 Incontinentia Pigmenti Among them, miR5p and miR-135b-5p were significantly downregulated by IPC. +other 34131111 hsa-mir-326 Adenocarcinoma of Lung Collectively, miR-326 restrained tumor progression by downregulating PD-L1 and B7-H3 expression and increasing T cell cytotoxic function in LUAD. +other 34131106 hsa-mir-21 Myocardial Reperfusion Injury Furthermore, we identified MARCH5 as a modifier of miR5p, and its effect on mitochondrial fission and fusion are directly proportional to PVT1 expression during H/R injury. +genetics_knock down_promote 34131104 hsa-mir-155 Carcinoma, Renal Cell Gain and loss-of-function studies further investigated the effect of transferred hypoxic exosomal miR +lncRNA target 34131102 hsa-mir-98 Thyroid Cancer, Papillary METHODS: Expression of lncRNA OIP5-AS1 and miR-98 in PTC tissue and cells were measured by quantitative real-time PCR (qRT-PCR). OIP5-AS1 promotes PTC cell progression through miR-98/ADAMTS8 and EGFR, MEK/ERK pathways. +genetics_overexpression_promote 34131101 hsa-mir-103a Carcinoma, Hepatocellular In addition, high miR-103a expression was associated with poor patient prognosis, and its overexpression promoted HCC cell growth and mobility. +other 34130645 hsa-mir-770 Squamous Cell Carcinoma of Head and Neck Furthermore, we validated that LINc02086/miR5p/SLC26A2 axis promoted migration in LSCC. +lncRNA target 34130607 hsa-let-7 Multiple Sclerosis T-cell activation potential in neurodegenerative diseases has been a research topic of interest in recent years Cytokines play an important role in the course and pathogenesis of MS, The aim of the present study was to analyze expression levels of miR-20, miR-21, miR-26, miR-155, and Let-7, which target the cytokines interleukin IL-17 and IL-23, in order to evaluate the relationship between MS and miRNAs that modulate the expression of cytokines involved in the autoimmune pathway.MATERIALS and METHODS: The study included 20 relapsing-remitting multiple sclerosis (MS) patients who were at least 18 years of age and were undergoing outpatient immunomodulatory therapy and 20 healthy, unrelated individuals who had no systemic disease and were not taking any medication as a control group. +circulation_biomarker_diagnosis_up 34130607 hsa-mir-26 Multiple Sclerosis T-cell activation potential in neurodegenerative diseases has been a research topic of interest in recent years Cytokines play an important role in the course and pathogenesis of MS, The aim of the present study was to analyze expression levels of miR-20, miR-21, miR-26, miR-155, and Let-7, which target the cytokines interleukin IL-17 and IL-23, in order to evaluate the relationship between MS and miRNAs that modulate the expression of cytokines involved in the autoimmune pathway.MATERIALS and METHODS: The study included 20 relapsing-remitting multiple sclerosis (MS) patients who were at least 18 years of age and were undergoing outpatient immunomodulatory therapy and 20 healthy, unrelated individuals who had no systemic disease and were not taking any medication as a control group. RESULTS: Comparison of miRNA expression levels in the peripheral blood samples and MS patients and healthy subjects revealed that the MS patients had significant upregulation of miR-20 and downregulation of miR-26 and miR-155 compared to the control group (p<0.005).CONCLUSION: Dysregulation of miRNA expression may play a role in the pathogenesis of MS. +circulation_biomarker_diagnosis_up 34130607 hsa-mir-20 Multiple Sclerosis T-cell activation potential in neurodegenerative diseases has been a research topic of interest in recent years Cytokines play an important role in the course and pathogenesis of MS, The aim of the present study was to analyze expression levels of miR-20, miR-21, miR-26, miR-155, and Let-7, which target the cytokines interleukin IL-17 and IL-23, in order to evaluate the relationship between MS and miRNAs that modulate the expression of cytokines involved in the autoimmune pathway.MATERIALS and METHODS: The study included 20 relapsing-remitting multiple sclerosis (MS) patients who were at least 18 years of age and were undergoing outpatient immunomodulatory therapy and 20 healthy, unrelated individuals who had no systemic disease and were not taking any medication as a control group. RESULTS: Comparison of miRNA expression levels in the peripheral blood samples and MS patients and healthy subjects revealed that the MS patients had significant upregulation of miR-20 and downregulation of miR-26 and miR-155 compared to the control group (p<0.005).CONCLUSION: Dysregulation of miRNA expression may play a role in the pathogenesis of MS. +lncRNA target 34130607 hsa-mir-21 Multiple Sclerosis T-cell activation potential in neurodegenerative diseases has been a research topic of interest in recent years Cytokines play an important role in the course and pathogenesis of MS, The aim of the present study was to analyze expression levels of miR-20, miR-21, miR-26, miR-155, and Let-7, which target the cytokines interleukin IL-17 and IL-23, in order to evaluate the relationship between MS and miRNAs that modulate the expression of cytokines involved in the autoimmune pathway.MATERIALS and METHODS: The study included 20 relapsing-remitting multiple sclerosis (MS) patients who were at least 18 years of age and were undergoing outpatient immunomodulatory therapy and 20 healthy, unrelated individuals who had no systemic disease and were not taking any medication as a control group. +circulation_biomarker_diagnosis_up 34130607 hsa-mir-155 Multiple Sclerosis T-cell activation potential in neurodegenerative diseases has been a research topic of interest in recent years Cytokines play an important role in the course and pathogenesis of MS, The aim of the present study was to analyze expression levels of miR-20, miR-21, miR-26, miR-155, and Let-7, which target the cytokines interleukin IL-17 and IL-23, in order to evaluate the relationship between MS and miRNAs that modulate the expression of cytokines involved in the autoimmune pathway.MATERIALS and METHODS: The study included 20 relapsing-remitting multiple sclerosis (MS) patients who were at least 18 years of age and were undergoing outpatient immunomodulatory therapy and 20 healthy, unrelated individuals who had no systemic disease and were not taking any medication as a control group. RESULTS: Comparison of miRNA expression levels in the peripheral blood samples and MS patients and healthy subjects revealed that the MS patients had significant upregulation of miR-20 and downregulation of miR-26 and miR-155 compared to the control group (p<0.005).CONCLUSION: Dysregulation of miRNA expression may play a role in the pathogenesis of MS. +lncRNA target 34130587 hsa-mir-17 Thyroid Neoplasms 5p inhibition repressed cell proliferation, clonal formation, cell migration, and cell invasion in thyroid carcinoma. +genetics_overexpression_promote 34130584 hsa-mir-188 Breast Neoplasms 3p, overexpression of TMED3 or blocking Wnt/beta-catenin signalling all attenuated the roles of RP11-283G6.5 in breast cancer. +genetics_overexpression_promote 34130294 hsa-mir-221 Adenocarcinoma, Follicular What's more, overexpression of GAS5 or miR +lncRNA target 34129971 hsa-mir-200a Glioma RESULTS: Expression of circNCAPG and RAB5A was upregulated, and miR-200a-3p was decreased in glioma tissues and cells, while their expression presented an opposite trend in Pro-treated glioma cells. CONCLUSIONS: Pro could inhibit glioma cell growth and metastasis through the circNCAPG/miR-200a-3p/RAB5A axis, providing a promising therapeutic strategy for glioma treatment. +exosome 34129838 hsa-mir-424 Colorectal Neoplasms CONCLUSION: Inhibited exosomal miR-424 from BMSCs inhibited malignant behaviors of CRC cells by targeting TGFBR3, thus suppressing the progression of CRC. +circulation_biomarker_diagnosis_up 34129195 hsa-mir-9 Retinoblastoma RESULTS: Initially, the expression level of miR-9 was significantly decreased in the RB tissues and blood samples from patients with RB. +other 34128858 hsa-mir-3199 Thymic epithelial tumor After lncRNA-miRNA-mRNA network construction and external cohort validation, a total of 4 DEmRNAs DOCK11, MCAM, MYO10, and WASF3 were identified and their associated-ceRNA modules were significantly associated with prognosis, which contained 3 lncRNAs (lncRNA LINC00665, lncRNA NR2F1-AS1, and lncRNA RP11-285A1.1), 4 mRNAs (DOCK11, MCAM, MYO10, and WASF3), and 4 miRNAs (hsa-mir-143, hsa-mir-141, hsa-mir-140, and hsa-mir-3199). +other 34128858 hsa-mir-143 Thymic epithelial tumor After lncRNA-miRNA-mRNA network construction and external cohort validation, a total of 4 DEmRNAs DOCK11, MCAM, MYO10, and WASF3 were identified and their associated-ceRNA modules were significantly associated with prognosis, which contained 3 lncRNAs (lncRNA LINC00665, lncRNA NR2F1-AS1, and lncRNA RP11-285A1.1), 4 mRNAs (DOCK11, MCAM, MYO10, and WASF3), and 4 miRNAs (hsa-mir-143, hsa-mir-141, hsa-mir-140, and hsa-mir-3199). +other 34128858 hsa-mir-141 Thymic epithelial tumor After lncRNA-miRNA-mRNA network construction and external cohort validation, a total of 4 DEmRNAs DOCK11, MCAM, MYO10, and WASF3 were identified and their associated-ceRNA modules were significantly associated with prognosis, which contained 3 lncRNAs (lncRNA LINC00665, lncRNA NR2F1-AS1, and lncRNA RP11-285A1.1), 4 mRNAs (DOCK11, MCAM, MYO10, and WASF3), and 4 miRNAs (hsa-mir-143, hsa-mir-141, hsa-mir-140, and hsa-mir-3199). +other 34128858 hsa-mir-140 Thymic epithelial tumor After lncRNA-miRNA-mRNA network construction and external cohort validation, a total of 4 DEmRNAs DOCK11, MCAM, MYO10, and WASF3 were identified and their associated-ceRNA modules were significantly associated with prognosis, which contained 3 lncRNAs (lncRNA LINC00665, lncRNA NR2F1-AS1, and lncRNA RP11-285A1.1), 4 mRNAs (DOCK11, MCAM, MYO10, and WASF3), and 4 miRNAs (hsa-mir-143, hsa-mir-141, hsa-mir-140, and hsa-mir-3199). +genetics_GWAS 34128842 hsa-mir-4766 Essential Hypertension 5p.The PTX3 rs2614 locus SNP is significantly associated with EHT risk. +lncRNA target 34128362 hsa-mir-93 Triple Negative Breast Neoplasms CONCLUSION: HAGLR could promote the progression of TNBC through the miR +circulation_biomarker_prognosis_ns 34127929 hsa-mir-614 Colorectal Neoplasms 5p expression of colorectal cancer was significantly correlated with N stage (OR) = 0.7 for N1&N2 vs. N0), M stage (OR = 0.5 for M1 vs. M0), pathologic stage (OR = 0.7 for Stage III & Stage IV vs. Stage I & Stage II), neoplasm type (OR = 0.5 for rectum adenocarcinoma vs. colon adenocarcinoma), and lymphatic invasion (OR = 0.6 for YES vs. NO) (all p-values < 0.05). +lncRNA target 34127806 hsa-mir-4736 Prostatic Neoplasms 3p and/or miR-4736/PPARgamma/MMP-9 signals may help in the development of new therapies to better suppress the Enz-altered PCa vs. +lncRNA target 34127806 hsa-mir-125b-2 Urinary Bladder Neoplasms 3p and/or miR-4736/PPARgamma/MMP-9 signals may help in the development of new therapies to better suppress the Enz-altered PCa vs. +lncRNA target 34127806 hsa-mir-4736 Urinary Bladder Neoplasms 3p and/or miR-4736/PPARgamma/MMP-9 signals may help in the development of new therapies to better suppress the Enz-altered PCa vs. +lncRNA target 34127806 hsa-mir-125b-2 Prostatic Neoplasms 3p and/or miR-4736/PPARgamma/MMP-9 signals may help in the development of new therapies to better suppress the Enz-altered PCa vs. +genetics_knock down_promote 34127015 hsa-mir-1205 Colorectal Neoplasms CircASXL1 knockdown inhibited cell colony-forming ability, migration and invasion, whereas induced cell arrest at G0/G1 phase and cell apoptosis in CRC cells; however, these effects were attenuated by miR-1205 inhibitor. +lncRNA target 34127010 hsa-mir-194 Carcinoma, Non-Small-Cell Lung 5p enhanced the sensitivity of NSCLC cells to DOX by directly inhibiting HIF-1. +lncRNA target 34126989 hsa-mir-135b Triple Negative Breast Neoplasms The bioinformatics prediction revealed that circ_0044234 could act as an upstream sponge in the miR-135b/GATA3 axis, two of the most dysregulated transcripts in TNBC. Our comprehensive approach revealed the potential circ_0044234/miR135b-5p/GATA3 ceRNA axis in TNBC. +lncRNA target 34126893 hsa-mir-15b Prostatic Neoplasms Mechanistically, AFAP1-AS1 functioned as an oncogene in PCa through binding to miR-15b and destroying its tumor suppressor function. CONCLUSION: AFAP1-AS1 facilitates PCa progression by regulating miR-15b/IGF1R axis, indicating that AFAP1-AS1 may serve as a diagnostic biomarker and therapeutic target for PCa. +genetics_overexpression_promote 34126886 hsa-mir-92a Carcinoma, Hepatocellular MTT, flow cytometry, wound healing, Transwell invasion assays and western blot were conducted to uncover that overexpressed miR-92a-3p could boost the proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) of HCC cells while inhibiting cell apoptosis. +circulation_biomarker_diagnosis_ns 34126831 hsa-mir-135b Diabetes, Gestational 5p and miR-3135b exhibited significantly lower expression in plasma samples from GDM patients. +circulation_biomarker_diagnosis_ns 34126831 hsa-mir-574 Diabetes, Gestational 5p and miR-3135b exhibited significantly lower expression in plasma samples from GDM patients. +lncRNA target 34126594 hsa-mir-27b Breast Neoplasms MiR-27b-3p targeted YAP in the breast cancer cells. +genetics_overexpression_promote 34126237 hsa-mir-23a Pulmonary Arterial Hypertension On the contrary, PAHRF-overexpressing plasmid inhibited the expression of miR-23a-3p in hypoxia. +lncRNA target 34125980 hsa-mir-181a Pulmonary Disease, Chronic Obstructive Mechanically, rescue assays demonstrated that miR-181a-5p inhibition could partially counteract the impact of LUCAT1 on COPD progression through the Wnt/beta-catenin pathway. +other 34125651 hsa-mir-144 Stomach Neoplasms This study aimed to evaluate the expression changes of miR-144 and miR-375 in the human gastric adenocarcinoma cell line (AGS) under the exposure of ELF-EMF. +other 34125651 hsa-mir-375 Stomach Neoplasms This study aimed to evaluate the expression changes of miR-144 and miR-375 in the human gastric adenocarcinoma cell line (AGS) under the exposure of ELF-EMF. Up-regulation of miR-144 and miR-375 were observed in AGS cells under the exposure of magnetic fields. +genetics_knock down_promote 34125645 hsa-mir-23a Breast Neoplasms MiR-323a-3p inhibition reversed the role of NORAD knockdown in the biological functions of BC cells while silencing PUM1 reversed the influence of NORAD overexpression on BC cells. +circulation_biomarker_prognosis_up 34125460 hsa-mir-222 Colorectal Neoplasms The results of our present study identified a gene cluster, miR-221/222, that is constitutively upregulated in serum exosome samples of patients with colorectal carcinoma (CRC) with liver metastasis (LM); this upregulation predicts a poor overall survival rate. Overall, our results show that exosomal miR-221/222 promotes CRC progression and may serve as a novel prognostic marker and therapeutic target for CRC with LM. +circulation_biomarker_prognosis_up 34125460 hsa-mir-221 Colorectal Neoplasms The results of our present study identified a gene cluster, miR-221/222, that is constitutively upregulated in serum exosome samples of patients with colorectal carcinoma (CRC) with liver metastasis (LM); this upregulation predicts a poor overall survival rate. Overall, our results show that exosomal miR-221/222 promotes CRC progression and may serve as a novel prognostic marker and therapeutic target for CRC with LM. +lncRNA target 34125401 hsa-mir-1178 Carcinoma, Hepatocellular 3p functions as a tumor suppressor in HCC through regulating TBL1XR1/PI3K/Akt pathway, and these findings could be a valid molecular target for liver cancer therapy. +genetics_knock down_promote 34124998 hsa-mir-425 Stomach Neoplasms This study aim to investigate the role of miR-425 in gastric cancer.The expression of miR-425 and Dickkopf-related protein-3(DKK-3) were analyzed by qRT-PCR. +transcription factor target 34124983 hsa-mir-195 Stomach Neoplasms 5p or elevated PD-L1 expression reverses the inhibitory effect of AS-IV on EMT and angiogenesis of GC cells. +genetics_knock down_promote 34124974 hsa-mir-877 Squamous Cell Carcinoma of Head and Neck 5p.Hsa_circ_0042823 promotes proliferation, migration, invasion of LSCC cells.Hsa_circ_0042823 knockdown inhibits tumour growth of LSCC via miR +genetics_knock down_promote 34124372 hsa-mir-431 Colorectal Neoplasms circ-CSPP1 directly targeted miR-431, and circ-CSPP1 knockdown modulated CRC cell progression in vitro via upregulating miR-431. +other 34124194 hsa-mir-3 Plaque, Atherosclerotic The analysis from atherosclerotic plaque revealed that Rb(1) treatment could result in an induction of Pigment epithelium-derived factor (PEDF) expression and reduction of the miR-33 generation. +transcription factor target 34124194 hsa-mir-3 Inflammation The anti-angiogenic and anti-inflammation effects of Rb(1) are exerted via the modulation of miR-33 and its target gene PEDF. +circRNA target 34124144 hsa-mir-132 Nasopharyngitis "GO and KEGG analysis showed differential circRNAs and miRNAs were enriched in ""amoebiasis,"" ""salivary secretion,"" ""pathways in cancer,"" and ""endocytosis."" Through qRT-PCR verification, the expression profiles of hsa-circ-0031593, hsa-circ-0031594, hsa-miR" +circRNA target 34124144 hsa-mir-145 Nasal Polyps "GO and KEGG analysis showed differential circRNAs and miRNAs were enriched in ""amoebiasis,"" ""salivary secretion,"" ""pathways in cancer,"" and ""endocytosis."" Through qRT-PCR verification, the expression profiles of hsa-circ-0031593, hsa-circ-0031594, hsa-miR" +circRNA target 34124144 hsa-mir-27b Nasal Polyps "GO and KEGG analysis showed differential circRNAs and miRNAs were enriched in ""amoebiasis,"" ""salivary secretion,"" ""pathways in cancer,"" and ""endocytosis."" Through qRT-PCR verification, the expression profiles of hsa-circ-0031593, hsa-circ-0031594, hsa-miR" +circRNA target 34124144 hsa-mir-27b Nasopharyngitis "GO and KEGG analysis showed differential circRNAs and miRNAs were enriched in ""amoebiasis,"" ""salivary secretion,"" ""pathways in cancer,"" and ""endocytosis."" Through qRT-PCR verification, the expression profiles of hsa-circ-0031593, hsa-circ-0031594, hsa-miR" +circRNA target 34124144 hsa-mir-146a Nasal Polyps "GO and KEGG analysis showed differential circRNAs and miRNAs were enriched in ""amoebiasis,"" ""salivary secretion,"" ""pathways in cancer,"" and ""endocytosis."" Through qRT-PCR verification, the expression profiles of hsa-circ-0031593, hsa-circ-0031594, hsa-miR" +circRNA target 34124144 hsa-mir-132 Nasal Polyps "GO and KEGG analysis showed differential circRNAs and miRNAs were enriched in ""amoebiasis,"" ""salivary secretion,"" ""pathways in cancer,"" and ""endocytosis."" Through qRT-PCR verification, the expression profiles of hsa-circ-0031593, hsa-circ-0031594, hsa-miR" +circRNA target 34124144 hsa-mir-145 Nasopharyngitis "GO and KEGG analysis showed differential circRNAs and miRNAs were enriched in ""amoebiasis,"" ""salivary secretion,"" ""pathways in cancer,"" and ""endocytosis."" Through qRT-PCR verification, the expression profiles of hsa-circ-0031593, hsa-circ-0031594, hsa-miR" +circRNA target 34124144 hsa-mir-146a Nasopharyngitis "GO and KEGG analysis showed differential circRNAs and miRNAs were enriched in ""amoebiasis,"" ""salivary secretion,"" ""pathways in cancer,"" and ""endocytosis."" Through qRT-PCR verification, the expression profiles of hsa-circ-0031593, hsa-circ-0031594, hsa-miR" +transcription factor target 34124097 hsa-mir-1 Ameloblastoma 3p suppressed malignant phenotypes of AB through down-regulating LAMP2-mediated autophagy, which could become an underlying target for AB therapy. +exosome 34124064 hsa-mir-1305 Stomach Neoplasms In conclusion, our results indicated a previously unknown regulatory pathway in which exosomal circ_0088300 derived from CAFs acts as a sponge of miR-1305 and promotes GC cell proliferation, migration and invasion; these data identify a potential biomarker and novel therapeutic target for GC in the future. +exosome 34124036 hsa-mir-6515 Osteoarthritis CONCLUSION: Exosomes may alleviate OA inflammation by regulating the LYRM4-AS1/GRPR/miR5p signaling pathway. +transcription factor target 34123589 hsa-mir-568 Spinal Cord Ischemia Moreover, inhibition of miR-3568 preserved hind limb function after SCII by reducing apoptosis, possibly through regulating GATA6, GATA4, and RBPJ in SCII. +circulation_biomarker_diagnosis_ns 34123418 hsa-mir-20a Obesity The expression of MALAT1 and miR-320a was correlated with the changes in the anthropometric and blood indices of obese children and adolescents, and their correlations with endothelial dysfunction markers were obtained. +other 34123373 hsa-mir-192 dystonia 5 These sensors showed a linear response to buffered miR-21, with a 17 fM limit of detection, and successfully discriminated between urine samples (n = 6) from DKD patients and unaffected control subjects (n = 6) by differential miR-192 detection. +other 34123373 hsa-mir-21 dystonia 5 These sensors showed a linear response to buffered miR-21, with a 17 fM limit of detection, and successfully discriminated between urine samples (n = 6) from DKD patients and unaffected control subjects (n = 6) by differential miR-192 detection. +lncRNA target 34122636 hsa-mir-145 Thymus Neoplasms In conclusion, si-MALAT1 significantly attenuated cell proliferation and apoptosis via the miR5p/HMGA2 pathway in thymic cancer cells. +circulation_biomarker_prognosis_ns 34122634 hsa-mir-135a Colonic Neoplasms The aim of the present study was to investigate the expression and prognostic value of microRNA-135a (miR-135a) and matrix metalloproteinase-13 (MMP-13) in serum of colon cancer (CC). +circulation_biomarker_prognosis_ns 34122634 hsa-mir-135 Colonic Neoplasms The aim of the present study was to investigate the expression and prognostic value of microRNA-135a (miR-135a) and matrix metalloproteinase-13 (MMP-13) in serum of colon cancer (CC). +target gene 34122631 hsa-mir-497 Triple Negative Breast Neoplasms miR-497 inhibits proliferation and invasion in triple-negative breast cancer cells via YAP1. +target gene 34122630 hsa-mir-768 Breast Neoplasms Decreased microRNA-768-3p expression indicates a poor prognosis in patients with breast cancer and promotes breast cancer cell viability, migration and invasion. +other 34122628 hsa-mir-588 Colorectal Neoplasms In addition, western blot analysis indicated that the effect of SNHG8 on autophagy in CRC cells was dependent on the miR-588/ATG7 axis. +exosome 34122615 hsa-mir-224 Carcinoma, Renal Cell 5p can enter ccRCC cells via CAF-derived exosomes, in turn, promoting the malignant behaviors of ccRCC cells, which indicates that miR +target gene 34122108 hsa-mir-382 Ovarian Neoplasms Lidocaine Promoted Ferroptosis by Targeting miR-382-5p /SLC7A11 Axis in Ovarian and Breast Cancer. +target gene 34122108 hsa-mir-382 Breast Neoplasms Lidocaine Promoted Ferroptosis by Targeting miR-382-5p /SLC7A11 Axis in Ovarian and Breast Cancer. +circulation_biomarker_diagnosis_up 34122072 hsa-mir-20a Pulmonary Embolism, Acute Among them, miR-let-7i-5p expression was upregulated in APTE and IPAH, while miRNA-320a was upregulated in CTEP and IPAH. We concluded that the incorporation of plasma circulating let-7i-5p and miRNA-320a in baseline and clinical characteristics of the patients reinforces differences between APTE and CTEPH in outcome evolution, as well as differences between CTEPH and IPAH in diseases form. +circulation_biomarker_diagnosis_up 34122072 hsa-mir-20a Familial Primary Pulmonary Hypertension Among them, miR-let-7i-5p expression was upregulated in APTE and IPAH, while miRNA-320a was upregulated in CTEP and IPAH. We concluded that the incorporation of plasma circulating let-7i-5p and miRNA-320a in baseline and clinical characteristics of the patients reinforces differences between APTE and CTEPH in outcome evolution, as well as differences between CTEPH and IPAH in diseases form. +circulation_biomarker_diagnosis_up 34122072 hsa-let-7i Familial Primary Pulmonary Hypertension Among them, miR-let-7i-5p expression was upregulated in APTE and IPAH, while miRNA-320a was upregulated in CTEP and IPAH. We concluded that the incorporation of plasma circulating let-7i-5p and miRNA-320a in baseline and clinical characteristics of the patients reinforces differences between APTE and CTEPH in outcome evolution, as well as differences between CTEPH and IPAH in diseases form. +circulation_biomarker_diagnosis_up 34122072 hsa-let-7i Pulmonary Embolism, Acute Among them, miR-let-7i-5p expression was upregulated in APTE and IPAH, while miRNA-320a was upregulated in CTEP and IPAH. We concluded that the incorporation of plasma circulating let-7i-5p and miRNA-320a in baseline and clinical characteristics of the patients reinforces differences between APTE and CTEPH in outcome evolution, as well as differences between CTEPH and IPAH in diseases form. +circulation_biomarker_diagnosis_ns 34121556 hsa-mir-340 Glomerulonephritis, Membranous 5p and TNF-alpha (or IL-6) content in serum of GN rats. +genetics_overexpression_promote 34121515 hsa-mir-218 Glioma Moreover, cell experiments validated that overexpressed TCF12 could promote the proliferation, migration, and invasion of glioma cells and inhibit their apoptosis, whereas overexpressing miR +transcription factor target 34121490 hsa-mir-134 Inflammation Inflammation and oxidative stress were increased in H(2)O(2)-induced PC12 cells but improved with DEX or miR-134 inhibitor treatment. +lncRNA target 34121317 hsa-mir-211 Depression 5p/Dyrk1A pathway may be critically involved in the pathogenesis of depression and serve as a potential therapeutic target for the treatment of depression. +genetics_overexpression_promote 34121238 hsa-mir-626 Squamous Cell Carcinoma of Head and Neck Overexpressed RASSF4 inhibited the proliferation, invasion, migration and epithelial-mesenchymal transition (EMT) of OSCC cells, promoted cell apoptosis, and blocked the Wnt/beta-Catenin pathway, which was reversed by miR-626 overexpression. +genetics_knock down_promote 34121038 hsa-mir-877 Osteosarcoma The knockdown of miR-877 promoted the migration and invasion and facilitated the proliferation of Saos-2 and U2OS cells, and the silence of GGCT abolished this effects. +lncRNA target 34120890 hsa-mir-513b Carcinoma, Hepatocellular MiR-513b-5p may be applied as a therapeutic target for HCC. +other 34120462 hsa-mir-130a Osteoarthritis Aim: To investigate whether kaempferol exhibited protective effects on osteoarthritis chondrocytes by modulating the XIST/miR-130a/STAT3 axis. +genetics_knock down_promote 34120407 hsa-mir-144 Acute Lung Injury Using gain- and loss-of-function approaches, we analysed the effects of miR-144 and its interaction with KLF2 on TRALI. +lncRNA target 34120306 hsa-mir-17 Cardiomegaly kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway and regulating autophagy. +exosome 34120145 hsa-mir-580 Breast Neoplasms Carcinoma-associated fibroblasts derived exosomes modulate breast cancer cell stemness through exonic circHIF1A by miR-580-5p in hypoxic stress. +circulation_biomarker_diagnosis_ns 34119828 hsa-mir-129 Diabetes Mellitus The exosomes isolated from the blood of DM rats showed more miR +other 34119822 hsa-mir-145 Squamous Cell Carcinoma of Head and Neck In general, our study demonstrated a novel regulatory mechanism that circ_0001461/miR-145/TLR4/NF-kappaB axis modulates oral squamous cell carcinoma progression. +transcription factor target 34118948 hsa-mir-1224 Ischemic Stroke Among those miRNAs, miR-1224 markedly increased 3 days after ischemic stroke. Passive transfer of NK cells treated with an miR-1224 inhibitor prevented the accumulation of a bacterial burden in the lungs after ischemic stroke, suggesting an enhanced immune defense of NK cells. +other 34118888 hsa-mir-3158 Carcinoma, Hepatocellular 5p and -548as-3p) significantly correlated with the development of HCC, which can be present as biomarkers after further completing studies. +lncRNA target 34118875 hsa-mir-143 Tracheal Stenosis The MIR143HG/miR-1275/ILK axis mediates beta-elemene-induced cell cycle arrest and apoptosis of airway granulation fibroblasts by modulating the ILK/Akt pathway, thereby inhibiting airway granulation proliferation and ultimately alleviating airway stenosis. +lncRNA target 34118875 hsa-mir-1275 Tracheal Stenosis The MIR143HG/miR-1275/ILK axis mediates beta-elemene-induced cell cycle arrest and apoptosis of airway granulation fibroblasts by modulating the ILK/Akt pathway, thereby inhibiting airway granulation proliferation and ultimately alleviating airway stenosis. +transcription factor target 34118643 hsa-mir-486 Parkinson Disease 5p gene targets for PD onset and progression. +lncRNA target 34118183 hsa-mir-181b Dwarfism, Pituitary The aging function was overrepresented in IGHD individuals, mediated by hsa-miR-31, hsa-miR-146b, hsa-miR-30e, hsa-miR-100, hsa-miR-181b-2, hsa-miR-195, and hsa-miR-181b-1, which target the FoxO and mTOR pathways. +lncRNA target 34118183 hsa-mir-195 Dwarfism, Pituitary The aging function was overrepresented in IGHD individuals, mediated by hsa-miR-31, hsa-miR-146b, hsa-miR-30e, hsa-miR-100, hsa-miR-181b-2, hsa-miR-195, and hsa-miR-181b-1, which target the FoxO and mTOR pathways. +lncRNA target 34118183 hsa-mir-146b Dwarfism, Pituitary The aging function was overrepresented in IGHD individuals, mediated by hsa-miR-31, hsa-miR-146b, hsa-miR-30e, hsa-miR-100, hsa-miR-181b-2, hsa-miR-195, and hsa-miR-181b-1, which target the FoxO and mTOR pathways. +lncRNA target 34118183 hsa-mir-1 Dwarfism, Pituitary The aging function was overrepresented in IGHD individuals, mediated by hsa-miR-31, hsa-miR-146b, hsa-miR-30e, hsa-miR-100, hsa-miR-181b-2, hsa-miR-195, and hsa-miR-181b-1, which target the FoxO and mTOR pathways. +lncRNA target 34118183 hsa-mir-181b-2 Dwarfism, Pituitary The aging function was overrepresented in IGHD individuals, mediated by hsa-miR-31, hsa-miR-146b, hsa-miR-30e, hsa-miR-100, hsa-miR-181b-2, hsa-miR-195, and hsa-miR-181b-1, which target the FoxO and mTOR pathways. +lncRNA target 34118183 hsa-mir-181b-1 Dwarfism, Pituitary The aging function was overrepresented in IGHD individuals, mediated by hsa-miR-31, hsa-miR-146b, hsa-miR-30e, hsa-miR-100, hsa-miR-181b-2, hsa-miR-195, and hsa-miR-181b-1, which target the FoxO and mTOR pathways. +lncRNA target 34118141 hsa-mir-124 Cognition Disorders OBJECTIVES: In the current study, we investigated if miR-124 can offer protection against cognitive deficits induced by sevoflurane in a spatial learning paradigm, and examined the molecular mechanisms through cell cultures. +lncRNA target 34118139 hsa-mir-197 Gallbladder Neoplasms Downregulation of miR-197 inhibited the proliferation and promoted the apoptosis of GBC cells, indicating potential therapeutic effects. +transcription factor target 34117764 hsa-mir-133a Esophageal Neoplasms MiR-133a-3p is a crucial tumour suppressor miRNA in EC, playing a tumour suppressor role by targeting CDCA8. +lncRNA target 34117688 hsa-mir-214 Squamous Cell Carcinoma of Head and Neck In this article, we report circFOXO3 promotes tumor growth and invasion of OSCC by targeting miR-214 which specifically degrades the lysine demethylase 2A (KDM2A). Collectively, our results proved that circFOXO3 sponges miR-214 to up-regulate the expression of KDM2A, thus promotes tumor progression in OSCC. +genetics_knock down_suppress 34117619 hsa-mir-124 Glioma In addition, miR-124 knockdown partially abolished the inhibitory roles of HOXA11-AS downregulation in glioma cells. +lncRNA target 34117611 hsa-mir-130b Melanoma Together, these data suggest the potential of miR-130b-3p to inhibit ferroptosis in melanoma cells and the mechanism was related to DKK1-mediated Nrf2/HO-1 pathway. +genetics_knock down_suppress 34117589 hsa-mir-15a Endometriosis Knockdown of circ_0075503 inhibited E2-induced enhancement of cell migration and invasion in eutopic ESCs by regulating miR-15a-5p/KLF12 axis, indicating a novel target for the treatment of endometriosis. +exosome 34117264 hsa-mir-636 Prostatic Neoplasms In this study, urinary exosomal miRNA expression profiles of 149 PCas were determined and the miRNAs associated with metastasis were identified: miR-21, miR-16, miR3p, miR-451, and miR-636. +exosome 34117264 hsa-mir-451 Prostatic Neoplasms In this study, urinary exosomal miRNA expression profiles of 149 PCas were determined and the miRNAs associated with metastasis were identified: miR-21, miR-16, miR3p, miR-451, and miR-636. +exosome 34117264 hsa-mir-16 Prostatic Neoplasms In this study, urinary exosomal miRNA expression profiles of 149 PCas were determined and the miRNAs associated with metastasis were identified: miR-21, miR-16, miR3p, miR-451, and miR-636. +exosome 34117264 hsa-mir-21 Prostatic Neoplasms In this study, urinary exosomal miRNA expression profiles of 149 PCas were determined and the miRNAs associated with metastasis were identified: miR-21, miR-16, miR3p, miR-451, and miR-636. +exosome 34117264 hsa-mir-142 Prostatic Neoplasms In this study, urinary exosomal miRNA expression profiles of 149 PCas were determined and the miRNAs associated with metastasis were identified: miR-21, miR-16, miR3p, miR-451, and miR-636. +genetics_knock down_promote 34116704 hsa-mir-361 Ovarian Neoplasms Rescue experiments revealed that LINC00922 knockdown inhibited OC cell proliferation, migration, invasion and EMT by regulating miR +genetics_overexpression_promote 34116691 hsa-mir-889 Carcinoma, Hepatocellular CONCLUSIONS: Overall, miR-889 was upregulated in hepatocellular carcinoma tissues and cell lines, and overexpression of miR-889 promoted cell proliferation, migration, and invasion in hepatocellular carcinoma cells. +lncRNA target 34116684 hsa-mir-24 Osteoarthritis CONCLUSIONS: In conclusion, our work provides important insight into targeting miR +genetics_overexpression_promote 34116237 hsa-mir-29b Muscular Atrophy The protective effects of exercise in Ang-induced muscle atrophy were inhibited by a PPARgamma inhibitor (T0070907) or adeno-associated virus serotype-8 (AAV8)-mediated miR-29b overexpression. +other 34116070 hsa-mir-532 Hypertension BACKGROUND: This study was carried out to investigate the effect of microRNA miR5p on the proliferation of hypertension endothelial cells. +lncRNA target 34115574 hsa-mir-223 Sepsis Our findings indicate MKNK1, one targets of miR +genetics_overexpression_suppress 34115555 hsa-mir-126 Sepsis In conclusion, miR-126 overexpression can prevent brain injury caused by BBB damage via the inhibition of NF-kappaB signaling pathway activity. +genetics_overexpression_suppress 34115555 hsa-mir-126 Brain Injuries In conclusion, miR-126 overexpression can prevent brain injury caused by BBB damage via the inhibition of NF-kappaB signaling pathway activity. +genetics_overexpression_promote 34115554 hsa-mir-509 Carcinoma, Hepatocellular 3p overexpression causes inhibition of the proliferation, migration, invasion and EMT of HCC cells by negatively regulating Twist, thereby suppressing HCC development and metastasis. +lncRNA target 34115526 hsa-mir-326 Myocardial Infarction Moreover, the micro (mi)RNA-messenger (m)RNA network was also visualized; the results showed that miRNA-143, miRNA-144, and miRNA-26 could target PTGS2 in AMI progression. +lncRNA target 34115526 hsa-mir-143 Myocardial Infarction Moreover, the micro (mi)RNA-messenger (m)RNA network was also visualized; the results showed that miRNA-143, miRNA-144, and miRNA-26 could target PTGS2 in AMI progression. +lncRNA target 34115526 hsa-mir-144 Myocardial Infarction Moreover, the micro (mi)RNA-messenger (m)RNA network was also visualized; the results showed that miRNA-143, miRNA-144, and miRNA-26 could target PTGS2 in AMI progression. +genetics_overexpression_promote 34115460 hsa-mir-379 Endometrial Neoplasms The results showed that overexpression of miR +tissue_expression_ns 34115333 hsa-mir-485 Breast Neoplasms 5p and upregulation of FLOT1 were capable of reversing the anticancer activities of A1BG-AS1 deficiency in terms of breast cancer cell malignancy. +lncRNA target 34115289 hsa-mir-490 Carcinoma, Non-Small-Cell Lung LncRNA CCDC144NL-AS1 can be used as an oncogene of NSCLC to predict patient prognosis and promote tumor proliferation, migration, and invasion by targeting miR3p. +transcription factor target 34115259 hsa-mir-133a Kidney Failure, Chronic Our findings provide insight into the potential use of miR-133a as a molecular target for diagnosing vascular calcification in end-stage renal disease. +transcription factor target 34114971 hsa-mir-187 salivary gland adenoid cystic carcinoma Conjointly, our data revealed that CXCR5 facilitated PNI through downregulating miR-187 to disinhibit S100A4 expression in SACC. +lncRNA target 34114917 hsa-mir-210 Brain Injuries However, there is no effective therapy for hypoxia-induced injury or OSAHS due to the elusive mechanism involved.Objective: This study aimed to assess the effects of paeoniflorin on hypoxia-induced injury and explore the underlying mechanism.Materials and methods: Hypoxic models of SD rats and CTX-TNA2 cells were used to assess the effect of paeoniflorin, and the expressions of hif1a, miR-210, caspase1 and GSDMD were detected using western blots and RT-PCR. After transfection of miR-210 mimics, the attenuation of pyroptosis induced by paeoniflorin was suppressed, which was accompanied by an increase of ROS levels, as well as LDH release, indicating a critical role of miR-210 in pyroptosis in astrocytes.Conclusions: Our findings demonstrated that paeoniflorin improved hypoxia-induced pyroptosis in astrocytes via depressing hif1a/miR-210/caspase1/GSDMD signaling, providing robust evidence for the treatment of hypoxic injury and OSAHS.HighlightsHypoxia induces severe injury and inflammatory response in the rat brain;Hypoxia enhanced pyroptotic level and led to an activation of astrocytes.;Paeoniflorin alleviates hypoxia-induced pyroptosis in astrocytes;Transfection of miR-210 mimics suppressed the effects of paeoniflorin on hypoxia-induced pyroptosis in astrocytes. +other 34114724 hsa-mir-146a Acute Lung Injury Moreover, STAT3 combined the promoter region of XIST to accelerate the transcription, constituting the positive feedback loop of XIST/miR-146a-5p/STAT3 in ALI. +transcription factor target 34114688 hsa-mir-31 Diabetic Foot 3p were found upregulated specifically in iPSC-derived diabetic fibroblasts, while their targets CAV1 and CDKN3 were suppressed. +transcription factor target 34114688 hsa-mir-197 Diabetic Foot 3p were found upregulated specifically in iPSC-derived diabetic fibroblasts, while their targets CAV1 and CDKN3 were suppressed. +lncRNA target 34114479 hsa-mir-498 Esophageal Squamous Cell Carcinoma miR-498 inhibited MDM2-mediated ATF3 degradation, thus suppressing autophagy and M2-like polarization of macrophages in esophageal cancer. +other 34113619 hsa-mir-181b Stomach Neoplasms The CAGE-MiR-181b-5p-S1PR1 Axis Regulates Anticancer Drug Resistance and Autophagy in Gastric Cancer Cells. +other 34113568 hsa-mir-214 Lymphoma, Large-Cell, Anaplastic 5p level may help to refine the prognostic stratification of pediatric ALK-positive ALCL. +lncRNA target 34113564 hsa-mir-378a Breast Neoplasms Upregulation of miR-378a-3p, on the other hand, can inhibit BRCA cell growth and proliferation. +lncRNA target 34113562 hsa-mir-20b Colorectal Neoplasms Mechanistically, through interacting with miR-320b in CRC, DLEU1 promoted the level of PRPS1 which was a target of miR-320b. +virus_miRNA 34113444 hsv1-mir-H1 Esophageal Sphincter, Lower in the LES of patients with achalasia, hsv1-miR-H1 was overexpressed +genetics_overexpression_promote 34113395 hsa-mir-34a pancreatic adenocarcinoma In PAAD cells, overexpression of IUR and miR-34a led to decreased invasive and migratory abilities. +lncRNA target 34113393 hsa-mir-138 Glioma Thus, SNHG7 may enhance glioma proliferation via modulating the miR5p/EZH2 signaling axis. +lncRNA target 34113391 hsa-mir-219a Gallbladder Neoplasms In addition, transfection with microRNA (miRNA/miR)-219a-5p inhibitor rescued short hairpin RNA-circMTO1-inhibited tumorigenesis of GBC cells, suggesting that miR-219a-5p acts as a downstream effector for circMTO1. Taken together, the results of the present study provide novel insight for the role of circMTO1-induced GBC tumorigenesis via regulation of miR-219a-5p expression. +circulation_biomarker_diagnosis_ns 34113163 hsa-mir-22 Cystadenocarcinoma, Serous, Ovarian 5p in blood suggested the migration risk of ovarian cancer. +transcription factor target 34113148 hsa-mir-200a Diabetic Retinopathy CONCLUSION: Our results demonstrated that miR-200a could be used as a potential therapy target through down-regulating PDLIM1 in DR. +other 34113144 hsa-mir-146b Insulin Resistance Berberine Ameliorates Hepatic Insulin Resistance by Regulating microRNA-146b/SIRT1 Pathway. +target gene 34113143 hsa-mir-140 Insulin Resistance miR-140-5p Aggravates Insulin Resistance via Directly Targeting GYS1 and PPP1CC in Insulin-Resistant HepG2 Cells. +target gene 34113130 hsa-mir-183 Carcinoma, Hepatocellular miR-183-5p Promotes HCC Migration/Invasion via Increasing Aerobic Glycolysis. +genetics_overexpression_promote 34113129 hsa-mir-340 Retinoblastoma Moreover, overexpression of WIF1 could repress retinoblastoma progression induced by miR-340 in vitro and in vivo. +target gene 34113122 hsa-mir-551b Carcinoma, Non-Small-Cell Lung LncRNA PVT1 Facilitates Proliferation, Migration and Invasion of NSCLC Cells via miR-551b/FGFR1 Axis. +circulation_biomarker_diagnosis_ns 34113113 hsa-mir-497 Myocardial Infarction The diagnostic value of plasma miRNA-497, cTnI, FABP3 and GPBB in pediatric sepsis complicated with myocardial injury was analyzed. +circulation_biomarker_diagnosis_ns 34113113 hsa-mir-497 Neonatal Sepsis The diagnostic value of plasma miRNA-497, cTnI, FABP3 and GPBB in pediatric sepsis complicated with myocardial injury was analyzed. +genetics_overexpression_promote 34113109 hsa-mir-130a Intracranial Aneurysm CONCLUSION: SAMMSON is overexpressed in IA and suppresses VSMC proliferation via inhibiting miR-130a maturation. +other 34112885 hsa-mir-506 Extra-Hepatic Portal Venous Obstruction 3p were higher in children with EHPVO than healthy group. +other 34112885 hsa-mir-124 Extra-Hepatic Portal Venous Obstruction 3p were higher in children with EHPVO than healthy group. +circulation_biomarker_prognosis_up 34112884 hsa-mir-451a Gallbladder Neoplasms Serum EVs miR-1246 and miR-451a were significantly upregulated and downregulated, respectively in GBC patients (P=0.005 and P=0.001), in line with their expression levels in cancer tissue according to an in silico analysis. Taken together, miR-1246 in serum EVs has potential application as a diagnostic and prognostic marker and miR-451a may be a novel therapeutic target in GBC. +other 34112774 hsa-mir-375 Prostatic Neoplasms 3p) from prostate cancer patients with active disease and in remission. +other 34112774 hsa-mir-141 Prostatic Neoplasms 3p) from prostate cancer patients with active disease and in remission. +other 34112731 hsa-mir-193b Sepsis Finally, the clinical significance of these results was supported by the finding of increased miR-193b-5p expression levels in lung autopsy samples from acute respiratory distress syndrome patients who died with diffuse alveolar damage. +other 34112731 hsa-mir-193b Acute Lung Injury Finally, the clinical significance of these results was supported by the finding of increased miR-193b-5p expression levels in lung autopsy samples from acute respiratory distress syndrome patients who died with diffuse alveolar damage. +lncRNA target 34112319 hsa-mir-132 Aortic Valve Stenosis OBJECTIVES: This study aimed to establish a novel porcine model of pressure-overload-induced heart failure and to determine the effect of inhibition of microribonucleic acid 132 (miR-132) on heart failure development in this model. CONCLUSIONS: The inhibition of miR-132 is a valid strategy in prevention of heart failure progression in hypertrophic heart disease and may be developed as a treatment for heart failure of nonischemic origin. +lncRNA target 34112319 hsa-mir-132 Heart Failure OBJECTIVES: This study aimed to establish a novel porcine model of pressure-overload-induced heart failure and to determine the effect of inhibition of microribonucleic acid 132 (miR-132) on heart failure development in this model. CONCLUSIONS: The inhibition of miR-132 is a valid strategy in prevention of heart failure progression in hypertrophic heart disease and may be developed as a treatment for heart failure of nonischemic origin. +circulation_biomarker_diagnosis_up 34112294 hsa-mir-1 Coronary Disease CONCLUSIONS: Circulating miR-1 might have the value for early diagnosis of coronary artery plaque rupture in SCAD patients. +circulation_biomarker_diagnosis_up 34112294 hsa-mir-1 Plaque, Atherosclerotic CONCLUSIONS: Circulating miR-1 might have the value for early diagnosis of coronary artery plaque rupture in SCAD patients. +target gene 34112163 hsa-mir-503 Liver Neoplasms Echinacoside exerts anti-tumor activity via the miR-503-3p/TGF-β1/Smad aixs in liver cancer. +genetics_overexpression_promote 34112159 hsa-mir-493 Glioma Functionally, the overexpression of circNALCN significantly inhibited the proliferation and migration of glioma cells, whereas miR +other 34112152 hsa-mir-106a Asthma EA demonstrated lower expression of miRNA-106a and miRNA-126a than nEA (p = 0.003 and p = 0.02) and EC had lower expression of miRNA-146a, -126a, -106a and 19b than nEC (p = 0.001, p = 0.003, p = 0.005 and p < 0.001 respectively). +other 34112152 hsa-mir-146a Asthma EA demonstrated lower expression of miRNA-106a and miRNA-126a than nEA (p = 0.003 and p = 0.02) and EC had lower expression of miRNA-146a, -126a, -106a and 19b than nEC (p = 0.001, p = 0.003, p = 0.005 and p < 0.001 respectively). +other 34112152 hsa-mir-126a Asthma EA demonstrated lower expression of miRNA-106a and miRNA-126a than nEA (p = 0.003 and p = 0.02) and EC had lower expression of miRNA-146a, -126a, -106a and 19b than nEC (p = 0.001, p = 0.003, p = 0.005 and p < 0.001 respectively). +circulation_biomarker_diagnosis_ns 34112145 hsa-mir-20a Lymphoma, Large B-Cell, Diffuse the regulation of miR-320a/XBP1 axis through LINC00963 for endoplasmic reticulum stress and autophagy in diffuse large B-cell lymphoma. +lncRNA target 34111659 hsa-mir-26a Kidney Diseases Herein, we described the discovery path of Se-Y antagonism in Cd-induced renal necroptosis in chicken through targeting miR-26a-5p/PTEN/PI3K/AKT signaling pathway. Taken together, our results showed that Se-Y has an added value to antagonize Cd-induced necroptosis in chicken kidney by regulating the miR-26a-5p/PTEN/PI3K/AKT signaling pathway and HSPs, indicating that Se-Y could serve as an effective antagonist on Cd-induced renal necroptosis in chickens. +lncRNA target 34111466 hsa-mir-431 Hepatitis, Autoimmune 5p may be a potential therapeutic target for AIH. +genetics_overexpression_suppress 34111240 hsa-mir-128a Leukemia, Myelomonocytic, Acute We show that miR-130b and miR-128a are downstream targets of MLL-AF4 and can individually drive the transition from a pre-leukemic stage to an acute leukemia in an entirely murine Mll-AF4 in vivo model. Interestingly, miR-130b overexpression led to a mixed/B-cell precursor (BCP)/myeloid leukemia, propagated by the lymphoid-primed multipotent progenitor (LMPP) population, whereas miR-128a overexpression resulted in a pro-B acute lymphoblastic leukemia (ALL), maintained by a highly expanded Il7r+c-Kit+ blast population. +genetics_overexpression_suppress 34111240 hsa-mir-130b Leukemia, Myelomonocytic, Acute We show that miR-130b and miR-128a are downstream targets of MLL-AF4 and can individually drive the transition from a pre-leukemic stage to an acute leukemia in an entirely murine Mll-AF4 in vivo model. Interestingly, miR-130b overexpression led to a mixed/B-cell precursor (BCP)/myeloid leukemia, propagated by the lymphoid-primed multipotent progenitor (LMPP) population, whereas miR-128a overexpression resulted in a pro-B acute lymphoblastic leukemia (ALL), maintained by a highly expanded Il7r+c-Kit+ blast population. +genetics_knock down_promote 34110962 hsa-mir-125b Pancreatic Carcinoma Furthermore, the effects of MIR210HG knockdown on HK2 and PKM2 expression, pancreatic cancer cell aggressive phenotypes, and glycolysis were significantly reversed by miR-125b-5p inhibition. +exosome 34110633 hsa-mir-135a Colorectal Neoplasms Exosomal miR-135a-5p initiated the large tumor suppressor kinase 2-yes-associated protein-matrix metalloproteinase 7 axis to promote the occurrence of CRC liver metastasis, and cluster of differentiation 30-TNF receptor-associated factor 2-p65-mediated immunosuppression signaling also contributed to this process. CONCLUSIONS: Hypoxia-induced exosomal miR-135a-5p correlates with the development, clinical severity, and prognosis of CRC liver metastases through the premetastatic niche; and our findings revealed that miR-135a-5p might be a promising target in halting CRC liver metastases. +transcription factor target 34110576 hsa-mir-34c Cardiovascular Diseases The purpose of this study was to explore the effect of miR-34c on PDGF-BB-induced HAVSMCs phenotypic transformation and proliferation via PDGFR-beta/SIRT1 pathway, so as to find a new method for early diagnosis and treatment of cardiovascular disease. +other 34110382 hsa-mir-103 Stomach Neoplasms In the present study, we aimed to clarify the association of CYTOR, miR-103, and RAB10 in gastric cancer progression. These findings suggest that the CYTOR/miR-103/RAB10 axis is a novel signaling pathway that facilitates gastric cancer progression. +genetics_overexpression_promote 34110366 hsa-mir-23b Glioma In addition, we demonstrated that overexpression of TLR4 abrogated the regulatory function of miR-23b-5p in glioma cells on cell proliferation, cell apoptosis, and the chemosensitivity of TMZ treatment. +other 34110104 hsa-mir-205 Carcinoma, Hepatocellular RESULTS: YB1 promoted HCC cell migration and tumor metastasis by regulating miR-205/200b-ZEB1 axis partially in a Snail-independent manner. CONCLUSION: This study reveals a previously undescribed mechanism by which YB1 promotes cancer progression by regulating the miR-205/200b-ZEB1 axis in HCC cells. +other 34110104 hsa-mir-200b Carcinoma, Hepatocellular RESULTS: YB1 promoted HCC cell migration and tumor metastasis by regulating miR-205/200b-ZEB1 axis partially in a Snail-independent manner. CONCLUSION: This study reveals a previously undescribed mechanism by which YB1 promotes cancer progression by regulating the miR-205/200b-ZEB1 axis in HCC cells. +other 34109708 hsa-mir-424 Pneumonia, Mycoplasma RESULTS: The expression level of linc00473 was low and miR5p was high in placenta of PE patients. +lncRNA target 34109707 hsa-mir-520g Rhabdomyosarcoma 1 Our data revealed that IGF2-AS and N-cadherin levels were notably decreased, and miR-520g was strikingly increased in the placentas from RM patients. CONCLUSIONS: These findings indicated that IGF2-AS facilitated trophoblast cell proliferation, migration, invasion, EMT, and suppressed cell apoptosis by regulating miR-520g/N-cadherin axis, providing potential biomarkers for RM. +lncRNA target 34109575 hsa-mir-340 Osteosarcoma 5p repressed the malignant phenotypes of OS via targeting NRF2 and regulating PI3K/AKT pathway and EMT. +other 34109431 hsa-mir-200b Lung Neoplasms In the present study, miR200b expression was found to be increased in cigarette smoke (CS)exposed BEAS2B cells, lung cancer cell lines and tumor tissue samples. +transcription factor target 34109430 hsa-mir-142 Colorectal Neoplasms Decreased expression of miR1423p may be associated with CRC tumorigenesis via Rac1ERK signaling. +transcription factor target 34109426 hsa-mir-199a Brain Ischemia However, the association between DEX and miR199a in CIR injury remains unknown. In conclusion, DEX inhibited expression of miR199a and improved neurocyte injury induced by CIR. +genetics_overexpression_promote 34109425 hsa-mir-451 Colorectal Neoplasms Overexpression of miR451 inhibited proliferation and migration, promoted apoptosis and enhanced the sensitivity of CRC cells to chemotherapy. +lncRNA target 34109193 hsa-mir-23a Colorectal Neoplasms Materials and Methods: Quantitative real-time polymerase chain reaction was used to determine the expression levels of EBLN3P and miR-323a-3p in CRC tissues and cell lines. Conclusion: EBLN3P promoted the development of CRC via targeting miR-323a-3p/UHMK1, which provided a new idea for treating CRC. +other 34108628 hsa-mir-224 Colonic Neoplasms In this research, a novel zinc-based nanoscale metal-organic framework (Zn-NMOF) coated with folic acid (FA) functionalized chitosan (CS) has been constructed and applied as efficient delivery of LNA (locked nucleic acid)-antisense miR-224 to colon cancer cell lines. +lncRNA target 34108451 hsa-mir-138 Carcinoma, Hepatocellular 5p/PTK2/Akt axis in HCC cells, indicating CircC16orf62 can be a therapeutic target with potentiality for liver cancer and a predictive marker for people with HCC. +circulation_biomarker_diagnosis_up 34108361 hsa-mir-34a Cerebral Hemorrhage ICH rat models were established utilizing the autologous blood injection method and the beneficial effect was found after DU20-penetrating-GB7 acupuncture along with decreased miR-34a-5p levels in the perihemorrhagic penumbra. +lncRNA target 34108309 hsa-mir-345 Thyroid Cancer, Papillary 5p suppressed PTC cell growth and motility via regulating FZD8. +other 34107956 hsa-mir-148b Colorectal Neoplasms Expression of DDIT4, TPTEP1, and miR-181d-5p showed significantly increased levels while SULF1 and miR-148b-3p showed decreased levels in CRC tissues compared to the adjacent normal tissues. +other 34107956 hsa-mir-181d Colorectal Neoplasms Expression of DDIT4, TPTEP1, and miR-181d-5p showed significantly increased levels while SULF1 and miR-148b-3p showed decreased levels in CRC tissues compared to the adjacent normal tissues. +genetics_overexpression_promote 34107856 hsa-mir-6734 Carcinoma, Non-Small-Cell Lung 3p overexpression on NSCLC progression were abrogated by upregulating ZEB2. +transcription factor target 34107852 hsa-mir-362 Diabetes, Gestational 5p might be a therapy target of GDM. +lncRNA target 34107580 hsa-mir-23b Carcinoma, Hepatocellular Conclusion: miR-23b can inhibit the proliferation, migration, invasion and vasculogenic mimicry formation, and enhance the sensitivity of lenvatinib drug in human hepatocellular carcinoma cells. +genetics_overexpression_promote 34107348 hsa-mir-214 Osteoarthritis In addition, overexpressed miR +lncRNA target 34107168 hsa-mir-221 Lung Neoplasms 3p to hamper both tumour growth and metastasis could be a new therapeutic approach for lung cancer. +lncRNA target 34107168 hsa-mir-126 Lung Neoplasms 3p to hamper both tumour growth and metastasis could be a new therapeutic approach for lung cancer. +transcription factor target 34107032 hsa-mir-7 Parkinson Disease Importantly, miR-7's primary target is an mRNA of alpha-synuclein, which contributes to the aetiology of Parkinson's disease. +circulation_biomarker_diagnosis_ns 34107000 hsa-mir-275 Trypanosomiasis This system induces a constitutive, 40% reduction in miR275 transcript abundance in the fly's midgut and results in obstructed blood digestion (gut weights increased by 52%), a significant increase (p-value < 0.0001) in fly survival following infection with an entomopathogenic bacteria, and a 78% increase in trypanosome infection prevalence. +lncRNA target 34106877 hsa-mir-500b Precursor Cell Lymphoblastic Leukemia-Lymphoma In vitro experiments suggested that LINC01278 promoted the proliferation of leukemic cells and inhibited leukemic cell apoptosis by targeting the inhibition of miR-500b-3p in cALL, and LINC01278 may be a biological target for the treatment of cALL in the future. +circulation_biomarker_diagnosis_ns 34106501 hsa-mir-142 Tuberculosis CONCLUSIONS: Integrating serum miR +circulation_biomarker_diagnosis_ns 34106260 hsa-let-7b Crohn Disease Furthermore, CD changed the miRNA profile of exosomes and further analysis revealed a differential expression of let-7b-5p. Furthermore, serum exosome-mediated let-7b-5p-mimic delivery may significantly alleviate colitis, providing potential novel insight into an exosome-based strategy for the diagnosis and treatment of CD. +genetics_GWAS 34105828 hsa-mir-455 Liver Cirrhosis Thus, the epigenetics mediated miR +circulation_biomarker_prognosis_up 34105500 hsa-mir-194 Graft vs Host Disease The expressions of plasma miR-181b and miR-194 collected on day 15 after HSCT were significantly upregulated in the patients with aGVHD in comparison with non-GVHD patients (P<0.05). +genetics_GWAS 34105469 hsa-mir-155 Lymphoma, Large B-Cell, Diffuse The relative expression of miR-155 and the polymorphism of MyD88 L265P were associated with lesion location, stage, BCL-2 protein expression and MyD88 protein expression in DLBCL patients (t=7.4618.8046.48710.812 2=10.6818.5997.25123.008P<0.05). +other 34105224 hsa-mir-211 Glioblastoma 5p/YY1 regulatory signaling axis in GBM. +other 34104831 hsa-mir-155 Coronary Artery Disease Relevance for Patients Although further investigations are needed to confirm the role of miRNA-155 and miRNA-126, they may serve as potential biomarkers detecting severity of CAD, lowering of kidney function and metabolic syndrome. +circulation_biomarker_diagnosis_ns 34104831 hsa-mir-145 Coronary Artery Disease Background and Aim Plasma circulating microRNA (miRNA)-126, -145, and -155 are associated with vascular remodeling, atherosclerotic lesion formation, and plaque vulnerability. +other 34104831 hsa-mir-126 Coronary Artery Disease Relevance for Patients Although further investigations are needed to confirm the role of miRNA-155 and miRNA-126, they may serve as potential biomarkers detecting severity of CAD, lowering of kidney function and metabolic syndrome. +lncRNA target 34104112 hsa-mir-146a Spinal Cord Injuries In the present study, our results demonstrated that EZH2 could mediate miR-146a-5p/HIF-1alpha to alleviate the inflammation and glycolysis after ASCI. +genetics_GWAS 34104082 hsa-mir-192 Endometrial Neoplasms 5p is a tumor suppressor miRNA that is epigenetically silenced by promoter methylation and may serve as a potential prognostic biomarker in EC. +genetics_knock down_suppress 34103997 hsa-mir-760 Osteosarcoma Moreover, EZH2 was identified as the target gene of miR-760 and EZH2 overexpression abolished miR +target gene 34103994 hsa-mir-155 Urinary Bladder Neoplasms LINC-PINT Inhibited Malignant Progression of Bladder Cancer by Targeting miR-155-5p. +genetics_overexpression_suppress 34103991 hsa-mir-136 Carcinoma, Squamous Cell, Cutaneous 5p on CSCC cell progression could be reversed by PRAF2 overexpression. +genetics_overexpression_promote 34103986 hsa-mir-10a Colorectal Neoplasms CONCLUSION: circFAT1 is overexpressed in CRC and may suppress CRC cell proliferation, invasion and migration by increasing miR-10a maturation. +lncRNA target 34103911 hsa-mir-485 Pulmonary Disease, Chronic Obstructive CONCLUSION: These findings elucidated that circ-HACE1 contributed to the CSE-induced cell damages in COPD cell models via regulating TLR4 by acting as the sponge of miR3p. +lncRNA target 34103010 hsa-mir-654 Atherosclerosis 3p inhibitor significantly reversed the inhibitory effects of si-TP73-AS1 on cell viability and apoptosis. +other 34102907 hsa-mir-132 Mouth Neoplasms CONCLUSION: circVAPA is highly expressed in oral cancer, and its abnormal expression might affect the proliferation, invasion and migration of oral cancer cells by modulating the miR-132/HOXA7 signaling axis. +other 34102651 hsa-mir-576 Carcinoma, Hepatocellular 3p and upregulating HIF-1alpha expression. +lncRNA target 34102644 hsa-mir-488 Spinal Cord Injuries RESULTS: After SCI induction, rats exhibited low Basso-Beattie-Bresnahan scores, promoted the release of inflammation-related factors and downregulated miR-488. CONCLUSION: MiR-488 inhibited neural inflammation and apoptosis in SCI via its binding with HMGB1-mediated restraint on the TLR4/NF-kappaB signaling pathway. +lncRNA target 34102610 hsa-mir-1303 Osteosarcoma Furthermore, we identified FGF7 is one direct target gene of miR-1303 in osteosarcoma cell. +transcription factor target 34102226 hsa-mir-892b Osteoarthritis CONCLUSION: MiR-892b antagomir inhibits the progression of OA via targeting Cyclin D1 and Cyclin D2. +genetics_knock down_suppress 34102206 hsa-mir-138 Retinoblastoma 5p, and SLC7A5 overexpression abated the anti-tumor roles of miR +other 34101749 hsa-mir-16 Breast Neoplasms 5p is a commonly used IC, it's not a suitable one for breast cancer studies. +transcription factor target 34101749 hsa-mir-361 Breast Neoplasms 5p had lower standard deviation and also was the only IC capable of detecting a significant up-regulation of hsa-miR +other 34101749 hsa-mir-16 Esophageal Squamous Cell Carcinoma 5p and U48 on 34 pairs of Primary breast tumor and their adjacent normal tissues using qRT-PCR. +other 34101749 hsa-mir-361 Esophageal Squamous Cell Carcinoma 5p and U48 on 34 pairs of Primary breast tumor and their adjacent normal tissues using qRT-PCR. +transcription factor target 34101749 hsa-mir-21 Breast Neoplasms 5p had lower standard deviation and also was the only IC capable of detecting a significant up-regulation of hsa-miR +lncRNA target 34101492 hsa-mir-613 Breast Neoplasms Following transfection with miR-613 mimic, the expression of miR-613 was elevated in the BC cells leading to inhibition of NAMPT expression at both mRNA and protein level as measured by real-time PCR and western blotting, respectively. +lncRNA target 34101281 hsa-mir-26a Hemorrhage Mechanistically, miR-26a, which is enriched in SA-Exo, improved angiogenesis both in SHED and HUVECs via regulating TGF-beta/SMAD2/3 signalling. CONCLUSIONS: In summary, these data reveal that SA-Exo shuttled miR-26a promotes angiogenesis via TGF-beta/SMAD2/3 signalling contributing to SHED aggregate-based pulp tissue regeneration. +circRNA target 34101064 hsa-mir-545 Sepsis In conclusion, our results showed that circ_0091702 could suppress LPS-induced HK2 cell injury via the miR3p/THBS2 axis, indicating that circ_0091702 might be an important biomarker for relieving sepsis-related AKI. +circRNA target 34101064 hsa-mir-545 Acute Kidney Injury In conclusion, our results showed that circ_0091702 could suppress LPS-induced HK2 cell injury via the miR3p/THBS2 axis, indicating that circ_0091702 might be an important biomarker for relieving sepsis-related AKI. +other 34100730 hsa-mir-146b Atrial Fibrillation 3p, miR-630, miR-146b-5p, and miR-367 had a potential diagnostic value to discriminate patients with AF from healthy controls in this study. +other 34100730 hsa-mir-367 Atrial Fibrillation 3p, miR-630, miR-146b-5p, and miR-367 had a potential diagnostic value to discriminate patients with AF from healthy controls in this study. +other 34100717 hsa-mir-125 Late Onset Disorders Our findings identify miR-125 as a conserved effector of the DR pathway and open the avenue for this small RNA molecule and its downstream effectors to be considered as potential drug candidates for the treatment of late-onset diseases and biomarkers for healthy aging in humans. +other 34100450 hsa-mir-488 Spinal Cord Injuries Furthermore, circPrkcsh may be used as an miR-488 sponge to regulate Ccl2 expression, which might provide a new potential therapy for SCI. +transcription factor target 34100379 hsa-mir-16 Necrobiotic Disorders Taken together, puerarin alleviates oxidative stress and pyroptosis in HG-stimulated HRECs through regulating the miR- 16-5p/CASP1 axis. +genetics_knock down_suppress 34100377 hsa-mir-671 Arthritis, Rheumatoid Thus, circ-PTTG1IP knockdown repressed cell proliferation, migration, invasion and inflammatory response in RA-FLSs by regulating the miR +genetics_overexpression_promote 34100183 hsa-mir-29a Colonic Neoplasms In addition, colon cancer Caco-2 cells, which constitutively overexpress B7-H3, were transfected with lentivirus particles for miR-29a upregulation. +tissue_expression_up 34100182 hsa-mir-338 Atherosclerosis 3p in the development of AS, VSMC proliferation and migration were evaluated by EdU incorporation assay, MTT assay, and wound healing assay. +genetics_overexpression_promote 34100174 hsa-mir-1298 Lung Injury 5p and suppressor of cytokine signaling 6 (SOCS6) were silenced or overexpressed in human bronchial epithelial cells (BEAS-2B). +other 34099864 hsa-mir-570 Prostatic Neoplasms SNV rs9860655 in the mature sequence of miR-570 was not present in benign prostate hyperplasia (BPH) tissue or cell lines but was detectable in clinical prostate cancer tissue samples and adjacent normal tissue. +transcription factor target 34099844 hsa-mir-21 Hyperlipidemias Taken together, these results demonstrated that aerobic exercise improved hyperlipidemia through miR-21a-5p-induced inhibition of target genes FABP7, HMGCR, ACAT1, and OLR1. +lncRNA target 34099597 hsa-mir-7 Lung Neoplasms LINC01272 suppressed cell multiplication and induced apoptosis via regulating the miR5p/CRLS1 axis in LC. +genetics_overexpression_promote 34099038 hsa-mir-378 Femur Head Necrosis overexpressing ASCs (miR +circulation_biomarker_diagnosis_up 34098850 hsa-mir-221 Squamous Cell Carcinoma of Head and Neck We used quantitative real-time PCR (qRT-PCR) and western blotting to determine PIK3R1 and miR-221 expressions in OSCC tissue or peripheral blood serum. +other 34098766 hsa-mir-223 ST Elevation Myocardial Infarction OBJECTIVE: To explore the role of miR-223 and miR-126 in predicting treatment responses to dual antiplatelet therapy (DAPT) in patients with ST-elevation myocardial infarction (STEMI). CONCLUSION: MiR-223 and miR-126 play a role in DAPT resistance and may provide potential biomarkers in patients with STEMI. +other 34098766 hsa-mir-126 ST Elevation Myocardial Infarction OBJECTIVE: To explore the role of miR-223 and miR-126 in predicting treatment responses to dual antiplatelet therapy (DAPT) in patients with ST-elevation myocardial infarction (STEMI). CONCLUSION: MiR-223 and miR-126 play a role in DAPT resistance and may provide potential biomarkers in patients with STEMI. +genetics_overexpression_promote 34098582 hsa-mir-195 Precursor Cell Lymphoblastic Leukemia-Lymphoma Key cell cycle regulators were downregulated upon miR-497/195 overexpression, and we identified cyclin-dependent kinase 4 (CDK4)- and cyclin-D3 (CCND3)-mediated control of G1/S transition as a principal mechanism for the suppression of BCP-ALL progression by miR-497/195. +genetics_overexpression_promote 34098582 hsa-mir-497 Precursor Cell Lymphoblastic Leukemia-Lymphoma Key cell cycle regulators were downregulated upon miR-497/195 overexpression, and we identified cyclin-dependent kinase 4 (CDK4)- and cyclin-D3 (CCND3)-mediated control of G1/S transition as a principal mechanism for the suppression of BCP-ALL progression by miR-497/195. +genetics_overexpression_promote 34098485 hsa-mir-194 Pancreatic Carcinoma In addition, we found that overexpression of miR +circRNA target 34098264 hsa-mir-6631 Syphilis 5p/DUSP6 crosstalk regulated H(2)S-induced pyroptosis in broilers trachea via ROS generation. +other 34098197 hsa-mir-18a Prostatic Neoplasms Taken together, our results suggest that miR-18a-5p might function as a tumor-promoting factor in PCa and might contribute to its proliferation. +genetics_overexpression_promote 34098061 hsa-mir-105 Stomach Neoplasms Overexpression of miR +lncRNA target 34098015 hsa-mir-744 Pituitary Neoplasms Taken together, LINC01116 boosted the progression of pituitary adenoma cells via regulating miR +other 34097926 hsa-mir-200a Reperfusion Injury In conclusion, our study suggests that circPVT1 protects the myocardium from MI and H/R injury by preventing miR-125b- and miR-200a-mediated apoptotic signaling. +other 34097926 hsa-mir-125b Reperfusion Injury In conclusion, our study suggests that circPVT1 protects the myocardium from MI and H/R injury by preventing miR-125b- and miR-200a-mediated apoptotic signaling. +lncRNA target 34097859 hsa-mir-20a Carcinoma, Non-Small-Cell Lung ZEB1 transcriptionally inhibited the expression of miR-320a and upregulated the expression of RAD51AP1, thereby promoting metastasis in NSCLC. +other 34097717 hsa-mir-29c Diabetic Nephropathies TUG1 regulates miR-29c-3p/SIRT1 and subsequent ERS to relieve high glucose induced renal epithelial cells injury, and suggests a potential role for TUG1 as a promising diagnostic marker of diabetic nephropathy. +lncRNA target 34097562 hsa-mir-181c Carcinoma, Hepatocellular Taken together, our study elucidated that ZSCAN16-AS1 expedited HCC progression via modulating the miR-181 c-5p/SPAG9 axis to activate the JNK pathway, which might be a highly potential HCC therapy and treatment target. +circRNA target 34097558 hsa-mir-135b Arthritis, Rheumatoid Hsa_circ_0044235 regulated NLRP3-mediated pyroptosis through miR-135b-5p-SIRT1 axis to regulate the development of RA. +genetics_knock down_promote 34097310 hsa-mir-625 Leukemia, Myeloid, Acute Circ_0012152 knockdown suppressed cell proliferation and promoted death by targeting SOX12 mediated by miR +circulation_biomarker_diagnosis_ns 34097306 hsa-mir-221 Pulmonary Disease, Chronic Obstructive RESULTS: Chronic obstructive pulmonary disease patients possessed higher serum levels of miR +circulation_biomarker_diagnosis_ns 34097306 hsa-mir-92a Pulmonary Disease, Chronic Obstructive RESULTS: Chronic obstructive pulmonary disease patients possessed higher serum levels of miR +lncRNA target 34097192 hsa-mir-424 Liver Neoplasms 5p/ARK5 axis, and thus may serve as a potential target for targeted therapy. +lncRNA target 34096776 hsa-mir-498 Osteosarcoma Experimental results indicated that miR-498 could directly target LEF1 in OS cells and that circ_0032463 could abrogate the tumor-inhibitory effect of miR-498 by upregulating LEF1 in OS. +circulation_biomarker_diagnosis_up 34096637 hsa-mir-26b Hepatitis, Alcoholic During a median follow-up of 346 days, 21% of AH patients died; these patients had higher body mass index (BMI), Model for End-Stage Liver Disease (MELD), and serum miR-30b-5p, miR-20a-5p, miR-146a-5p, and miR-26b-5p than those who survived. +circulation_biomarker_diagnosis_up 34096637 hsa-mir-146a Hepatitis, Alcoholic During a median follow-up of 346 days, 21% of AH patients died; these patients had higher body mass index (BMI), Model for End-Stage Liver Disease (MELD), and serum miR-30b-5p, miR-20a-5p, miR-146a-5p, and miR-26b-5p than those who survived. Cox regression analysis showed that BMI, MELD score, miR-20a-5p, miR-146a-5p, and miR-26b-5p predicted mortality. +circulation_biomarker_diagnosis_up 34096637 hsa-mir-20a Hepatitis, Alcoholic During a median follow-up of 346 days, 21% of AH patients died; these patients had higher body mass index (BMI), Model for End-Stage Liver Disease (MELD), and serum miR-30b-5p, miR-20a-5p, miR-146a-5p, and miR-26b-5p than those who survived. +lncRNA target 34096570 hsa-mir-27a Carcinoma, Hepatocellular Taken together, miR-27a-3p acted as a tumor suppressor gene in HCC cells, and it could be useful for modulating cisplatin sensitivity in chemotherapy. +exosome 34096448 hsa-mir-20a Lung Neoplasms Hence, our goal here was to investigate the relevance of miR-320a-containing exosomes from HUCMSCs to lung cancer. Altogether, exosomes carrying miR-320a from HUCMSCs might suppress lung cancer cell growth via the SOX4/Wnt/beta-catenin axis, which highpoints the potency of exosomes expressing miR-320a as a possible therapeutic option for lung cancer treatment. +circRNA target 34096408 hsa-mir-1228 psoriasis 1 CONCLUSIONS: CircRAB3B suppressed psoriasis progression partly through down-regulating miR3p and up-regulating PTEN. +circRNA target 34096368 hsa-mir-646 Diabetic Retinopathy CONCLUSION: Circ_0000615 contributed to HG-induced HRPE cell dysfunction via miR-646/YAP1 axis, suggesting a novel insight into the pathogenesis of DR and a potential candidate for DR treatment. +circulation_biomarker_diagnosis_ns 34096222 hsa-mir-24 Alzheimer Disease 3p in serums of AD patients and to understand their roles in AD physiopathogenesis by in silico analysis. +circulation_biomarker_diagnosis_ns 34096222 hsa-mir-31 Alzheimer Disease 3p in serums of AD patients and to understand their roles in AD physiopathogenesis by in silico analysis. +lncRNA target 34096221 hsa-mir-373 Pancreatic Carcinoma dependent SIRT1 inhibition displays anti-proliferative and proapoptotic roles in PC cells via PGC-1alpha/NRF2 pathway, which highlights miR-373 as a potential target for PC treatment. +lncRNA target 34096173 hsa-let-7i Melanoma In the in vitro part of the study, Let-7i mimics were transfected and the impact of its restoration on target gene expression, proliferation, migration and apoptosis of SK-MEL-3 melanoma cell line was assessed by real-time PCR and Western blotting, MTT assay, wound-healing assay and flow cytometry, respectively. +circulation_biomarker_diagnosis_ns 34096020 hsa-mir-28 Diabetes Mellitus, Type 2 5p in the plasma may be closely associated with the pathogenesis of T2DM. +circulation_biomarker_diagnosis_ns 34096020 hsa-mir-185 Diabetes Mellitus, Type 2 5p in the plasma may be closely associated with the pathogenesis of T2DM. +lncRNA target 34095625 hsa-mir-22 Instent Restenosis More importantly, the PCEC@miR-22 coated stents showed reduced inflammation, low switching of SMC phenotype, and low secretion of extracellular matrix, which significantly inhibited IRS. +circulation_biomarker_diagnosis_ns 34095555 hsa-mir-9 psoriasis 1 OBJECTIVES: This study was performed to detect the expression of serum and tissue (lesion and non-lesion) LncRNA MALAT-1 and MiRNA-9 that might be used as biomarkers for psoriasis. CONCLUSION: This study highlights the dysregulation of LncRNA MALAT-1 and miRNA-9 in psoriasis. +genetics_knock down_promote 34095464 hsa-mir-376 Carcinoma, Hepatocellular Overexpression and knockdown experiments were performed in HCC cells to examine the effects of the SNHG1/miR-376/FOXK1/Snail axis on viability, apoptosis, invasiveness, and migrating abilities. +genetics_knock down_promote 34095464 hsa-mir-376a Carcinoma, Hepatocellular Overexpression and knockdown experiments were performed in HCC cells to examine the effects of the SNHG1/miR-376/FOXK1/Snail axis on viability, apoptosis, invasiveness, and migrating abilities. +circulation_biomarker_diagnosis_ns 34095322 hsa-mir-146a Aortic Valve Insufficiency Additionally, the miR-146a-5p expression was negatively associated with the SERPINB2 expression in the serum of AR patients. miR-146a-5p and SERPINB2 could be applied as potential targets for AR treatment. +exosome 34095151 hsa-mir-224 Breast Neoplasms miR-224-5p Carried by Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomes Regulates Autophagy in Breast Cancer Cells via HOXA5. +lncRNA target 34094954 hsa-mir-494 Prostatic Neoplasms CONCLUSIONS: Our study reveals that LINC00467 promotes prostate cancer progression via M2 macrophage polarization and the miR3p/STAT3 axis. +other 34094949 hsa-mir-486 Lung Neoplasms 5p exerts in NSCLC, and its expression pattern in the different stages and morphologies of NSCLC makes it a promising biomarker in the early diagnosis of the disease. +transcription factor target 34094932 hsa-mir-139 Stomach Neoplasms Mechanistically, HOXA13, directly targeted by miR5p in GC, might upregulate ABCC4 expression, thereby accentuating 5-FU resistance of GC cells. +lncRNA target 34094925 hsa-mir-4772 Pancreatic Carcinoma RESULTS: A prognostic model containing four downregulated miRNAs (hsa-mir-424, hsa-mir-3613, hsa-mir-4772 and hsa-mir-126) related to the prognosis of pancreatic cancer was constructed. Among them, one novel miRNA (hsa-mir-4772) and two novel genes (COL12A1 and COL5A2) associated with pancreatic cancer have great potential to be used as prognostic factors and therapeutic targets for this tumor. +other 34094916 hsa-mir-137 Glioblastoma We conclude that lncRNA HAS2-AS1 promotes proliferation by functioning as a miR-137 decoy to increase LSD1 levels and thus might be a possible biomarker for GBM. +other 34094909 hsa-mir-96 cervical adenocarcinoma 3p, promoting the MODY activation in cervical ADC. +other 34094909 hsa-mir-96 Uterine Cervical Neoplasms 3p, promoting the MODY activation in cervical ADC. +other 34094909 hsa-mir-28 cervical adenocarcinoma 3p, promoting the MODY activation in cervical ADC. +other 34094909 hsa-mir-28 Uterine Cervical Neoplasms 3p, promoting the MODY activation in cervical ADC. +lncRNA target 34094894 hsa-mir-145 Melanoma In conclusion, these findings demonstrate that FUT8-AS1 exerts tumor suppressive roles in melanoma via regulating NF90/miR +exosome 34094717 hsa-mir-144 Nasopharyngeal Carcinoma Notably, miR-144 was identified as a mediator in NPC-EV-induced regulatory effects through the inhibition of the target gene FBXW7 and promotion of the transcriptional factor HIF-1alpha-dependent vascular endothelial growth factor (VEGF-A). +genetics_knock down_suppress 34094712 hsa-mir-98 Mental Disorders Our findings revealed that the knockdown of lncRNA Xist ameliorates sevoflurane-induced social and emotional impairment through inhibiting neuronal apoptosis and ER stress by targeting the miR +lncRNA target 34094710 hsa-mir-337 Endometrial Neoplasms Our findings on the MIR210HG-miR3p/137-HMGA2 axis illustrate its potential as a target for endometrial cancer therapeutic development. +other 34094708 hsa-mir-146 Alzheimer Disease Interestingly, constitutive activation of mTORC1 by Rheb activator restricts proinflammatory cytokine production by reactivating miR-146 miRNPs in amyloid beta-exposed glial cells to rescue the disease phenotype in the in vivo rat model of Alzheimer's disease. +exosome 34094673 hsa-mir-429 Carcinoma, Ovarian Epithelial Exosomal transfer of miR-429 confers chemoresistance in epithelial ovarian cancer. +target gene 34094665 hsa-mir-206 Hepatoblastoma βKlotho, a direct target of miR-206, contributes to the growth of hepatoblastoma through augmenting PI3K/Akt/mTOR signaling. +other 34094547 hsa-mir-221 thyroid gland Hurthle cell carcinoma Furthermore, in the first case [Hurthle cell carcinoma (HCC)], increased miRNA-221 content was detected, which also indicated malignancy. +other 34094547 hsa-mir-146b thyroid gland Hurthle cell carcinoma In the second case (Hurthle cell papillary thyroid carcinoma), an increased level of miRNA-146b was present, which indicated papillary carcinoma. +genetics_overexpression_promote 34093945 hsa-mir-532 Ovarian Neoplasms 5p, and its overexpression could partially offset the influence of miR +circulation_biomarker_prognosis_down 34093857 hsa-mir-138 Breast Neoplasms 5p promoted lung metastasis, and the level of circulating exosomal miR +other 34093839 hsa-let-7c Stomach Neoplasms The hsa_circ_0001483/hsa_circ_0001324-hsa-let-7c-PGC axis in GC may account for the down-regulation of PGC in GC tissue. +lncRNA target 34093832 hsa-mir-635 Nasopharyngeal Carcinoma MiR-635 was demonstrated as a direct target of circRANBP17; circRANBP17 up-regulated RUNX2 expression levels by sponging miR-635, thereby promoting NPC proliferation and invasion. +circRNA target 34093821 hsa-mir-1278 Carcinoma, Non-Small-Cell Lung In conclusion, we revelaed the vital role of circ0101675-miRWNT3A/5A signaling in NSCLC progression via the competing endogenous RNAs mechanism. +target gene 34093820 hsa-mir-1246 Leukemia MicroRNA-1246 by Targeting AXIN2 and GSK-3β Overcomes Drug Resistance and Induces Apoptosis in Chemo-resistant Leukemia Cells. +lncRNA target 34093817 hsa-mir-548k Laryngeal Neoplasms Moreover, the screened pRS-related ceRNA network and circ_0002951/miR-548k/HAS2 pathway provide potential therapeutic targets and biomarkers of laryngocarcinoma. +genetics_overexpression_promote 34093798 hsa-mir-876 Colorectal Neoplasms Additionally, LINC01272 or ITGB2 silencing reduced, while miR-876 overexpression promoted, the invasiveness and metastatic capacity of CRC cells in vitro. +other 34093766 hsa-mir-126 Myocardial Reperfusion Injury PI3K/AKT axis in D-MI/R rats. +other 34093766 hsa-mir-126 Diabetes Mellitus PI3K/AKT axis in D-MI/R rats. +lncRNA target 34093756 hsa-mir-150 Osteoarthritis The present study demonstrated that silencing lincRNA-Cox2 expression plays a protective role in OA by enhancing the proliferation and suppressing the apoptosis of chondrocytes, which is related to increased miR-150 expression and activation of the Wnt/beta-catenin pathway. +lncRNA target 34093751 hsa-mir-9 Pancreatitis However, the role and potential mechanism of miR-9 in AP progression remains unclear. As a result, miR-9 decreased inflammatory response and apoptosis in caerulein-treated AR42J cells by targeting FGF10 and blocking NF-kappaB signaling, suggesting that miR-9 may serve as a novel target for AP treatment. +genetics_overexpression_promote 34093749 hsa-mir-296 Colorectal Neoplasms HMGA1 was overexpressed in CRC tissues and was inversely correlated with the expression of miR +genetics_overexpression_promote 34093664 hsa-mir-574 Colorectal Neoplasms 3p, and its overexpression reversed the inhibition effect of miR +other 34093662 hsa-mir-15a Esophageal Neoplasms 5p were correlated to the shorter survival time in patients with EC. +other 34093662 hsa-mir-92a Esophageal Neoplasms 5p were correlated to the shorter survival time in patients with EC. +other 34093662 hsa-mir-181b Esophageal Neoplasms 5p were correlated to the shorter survival time in patients with EC. +other 34093662 hsa-mir-590 Esophageal Neoplasms 5p were correlated to the shorter survival time in patients with EC. +other 34093662 hsa-mir-93 Esophageal Neoplasms 5p were correlated to the shorter survival time in patients with EC. +other 34093662 hsa-mir-92a-1 Esophageal Neoplasms 5p were correlated to the shorter survival time in patients with EC. +other 34093662 hsa-mir-25 Esophageal Neoplasms 5p were correlated to the shorter survival time in patients with EC. +other 34093662 hsa-mir-421 Esophageal Neoplasms 5p were correlated to the shorter survival time in patients with EC. +lncRNA target 34093648 hsa-mir-766 Osteoarthritis In conclusion, exhausting circ_0136474 could mitigate OA chondrocyte oxidative injury through regulating miR +other 34093646 hsa-mir-181 Diastrophic dysplasia 13bp-Insertion-allele vector (P < 0.05), suggesting the reduced binding capability with miR-181 in DD genotype. +circulation_biomarker_diagnosis_ns 34093203 hsa-mir-29b Hypercholesterolemia CONCLUSION: Data suggest that circulating miRNA-30c-5p and miRNA-29b-3p are associated with hypercholesterolemia. +circRNA target 34093041 hsa-mir-21 Neuroblastoma CONCLUSION: We suggest that circRNA-TBC1D4, circRNA-NAALAD2 and circRNA-TGFBR3 may be cancer suppressor genes, which act by sponging miR-21 in NB. +genetics_GWAS 34092821 hsa-mir-27b Depression OBJECTIVE: The objective of this study was to investigate the effect of polymorphisms of the CYP3A4, CYP2C9, CYP3A5, ABCB1, CYP2C19, SCL6A4, and 5-HTR2A genes on the concentration/dose indicator of mirtazapine and on the CYP3A expression level obtained by measuring the miR-27b plasma concentration levels in patients suffering from a recurrent depressive disorder. +genetics_GWAS 34092821 hsa-mir-27b Alcoholism OBJECTIVE: The objective of this study was to investigate the effect of polymorphisms of the CYP3A4, CYP2C9, CYP3A5, ABCB1, CYP2C19, SCL6A4, and 5-HTR2A genes on the concentration/dose indicator of mirtazapine and on the CYP3A expression level obtained by measuring the miR-27b plasma concentration levels in patients suffering from a recurrent depressive disorder. +genetics_overexpression_promote 34092750 hsa-mir-224 Rhinitis, Allergic 5p overexpression. +genetics_overexpression_promote 34092745 hsa-mir-346 Hypoadrenocorticism, Familial MiR-346 overexpression offset circHACE1 elevation-mediated effects on malignant behaviors of differentiated THCA cells. +lncRNA target 34092624 hsa-mir-125a Finnish lethal neonatal metabolic syndrome Our findings revealed that circLMF1 deficiency could inhibit cell viability, cell cycle progression, and migration of PDGF-BB stimulated atherosclerosis model partly through the miR-125a-3p/VEGFA or FGF1 axis, suggesting that targeting circLMF1 can be a feasible therapeutic strategy for atherosclerosis. +circulation_biomarker_diagnosis_up 34092606 hsa-mir-762 Colorectal Neoplasms Conclusions, the present study suggests that circulating miR-762 might be a potential biomarker for upregulation of CRC cell growth and invasion, and may be accompanied by the Wnt/beta-catenin signaling. +circulation_biomarker_prognosis_ns 34092580 hsa-mir-9 Breast Neoplasms RESULTS: Results showed that serum expression of both miRNAs 9 and 342 can be used for the diagnosis of different types of BC. +transcription factor target 34092292 hsa-mir-520a Sciatica The purpose of this study is to verify the regulatory relationship between miR-520a and p65 and to explore how miR-520a/P65 affects the level of cytokines under the action of piperine, so as to play a therapeutic role in sciatica. MiR-520a can specifically and directly target P65, and piperine can promote the expression of miR-520a, then inhibit the expression of p65, down-regulate the pro-inflammatory factors IL-1beta and TNF-alpha, and up-regulate the effects of anti-inflammatory factors IL-10 and TGF-beta1, so as to treat sciatica. +lncRNA target 34092219 hsa-mir-128 Sepsis CONCLUSIONS: Overall, down-regulating SNHG16 alleviated the sepsis-mediated ALI by regulating miR +lncRNA target 34092219 hsa-mir-128 Acute Lung Injury CONCLUSIONS: Overall, down-regulating SNHG16 alleviated the sepsis-mediated ALI by regulating miR +other 34092168 hsa-mir-24 Multiple Myeloma 3p) that could be a potential biomarker of PN. +other 34092168 hsa-mir-24 Peripheral Nervous System Diseases 3p) that could be a potential biomarker of PN. +other 34092168 hsa-mir-22 Multiple Myeloma 3p) that could be a potential biomarker of PN. +other 34092168 hsa-mir-23a Multiple Myeloma 3p) that could be a potential biomarker of PN. +other 34092168 hsa-mir-22 Peripheral Nervous System Diseases 3p) that could be a potential biomarker of PN. +other 34092168 hsa-mir-23a Peripheral Nervous System Diseases 3p) that could be a potential biomarker of PN. +other 34092127 hsa-mir-20b Ovarian Neoplasms Our findings suggest that miR-20b may have therapeutic value in combination with olaparib treatment for ovarian cancer. +lncRNA target 34092081 hsa-mir-150 Acute Lung Injury However, the expression and significance of miR-150, AKT3 and SRPK1 in acute lung injury (ALI) were not clear. In conclusion, miR-150 and SRPK1 separately and cooperatively participate into inflammatory responses in ALI through regulating AKT3 pathway. +other 34092081 hsa-mir-150 Pneumonia Increased miR-150 and silenced SRPK1 may be a novel potential factor for preventing and treating more inflammatory lung diseases. +transcription factor target 34092046 hsa-mir-93 Femur Head Necrosis 5p inhibitor could promote osteogenic differentiation by increasing BMP-2 expression during the development of TIONFH. +transcription factor target 34092046 hsa-mir-93 Wounds and Injuries 5p inhibitor could promote osteogenic differentiation by increasing BMP-2 expression during the development of TIONFH. +other 34091883 hsa-mir-223 Cardiovascular Diseases In conclusion, a total of 45 miRs were associated with platelet function or maturity in patients with CVD, with miR-223 and miR-126 being the most frequently investigated. +other 34091883 hsa-mir-126 Cardiovascular Diseases In conclusion, a total of 45 miRs were associated with platelet function or maturity in patients with CVD, with miR-223 and miR-126 being the most frequently investigated. +circRNA target 34091806 hsa-mir-27b Lupus Nephritis CircELK4 contributes to renal injury by promoting inflammation and cell apoptosis via acting as a miR-27b-3p sponge to modulate STING/IRF3/IFN-I signaling in LN. +lncRNA target 34091757 hsa-mir-26a Diabetic Cardiomyopathies CONCLUSION: Our study showed that GAS5 promotes DCM progression by regulating miR-26a/b-5p, suggesting that GAS5 might be a potential therapeutic target for DCM. +lncRNA target 34091757 hsa-mir-26b Diabetic Cardiomyopathies CONCLUSION: Our study showed that GAS5 promotes DCM progression by regulating miR-26a/b-5p, suggesting that GAS5 might be a potential therapeutic target for DCM. +genetics_overexpression_promote 34091587 hsa-mir-502 Pituitary Neoplasms Mechanistically, overexpression of LINC00473 restricts miR3p through the ceRNA mechanism, upregulates KMT5A expression, and promotes the expression of cyclin D1 and CDK2, which is conducive to the cell cycle process, thereby promoting the proliferation of PA cells, involving IPA progression. +circulation_biomarker_diagnosis_ns 34091460 hsa-mir-221 psoriasis 1 3p was significantly increased in the serum of patients with psoriasis. +lncRNA target 34091391 hsa-mir-599 Colorectal Neoplasms CONCLUSIONS: Circ_0084615 is a tumor-promoting circRNA in CRC that functions as a competing endogenous RNA to regulate DNMT3A expression via sponging miR-599. +lncRNA target 34091390 hsa-mir-650 Nasopharyngeal Carcinoma CONCLUSION Our results demonstrated for the first time that miR-3650 was markedly upregulated in NPC tissues and positively associated with tumor progression and poor survival, suggesting that miR-3650 may be a potential novel prognostic biomarker and therapeutic target for NPC patients. +lncRNA target 34091117 hsa-mir-155 Encephalomyelitis, Autoimmune, Experimental In conclusion, the alleviation of EAE by EA is characterized by reduced proportions of Th1/Th17 cells and increased proportions of Th2 cells, POMC upregulation, and miR-155 downregulation, while miR-155 itself can suppress POMC expression. +genetics_GWAS 34090498 hsa-mir-125b Nerve Degeneration Halting neurodegeneration in DOX-induced chemobrain was achieved through epigenetic induction of key factors in Wnt/-catenin and hedgehog signaling pathways mediated primarily by the most abundant secreted exosomal miRNAs (miR +genetics_GWAS 34090498 hsa-mir-24 Nerve Degeneration Halting neurodegeneration in DOX-induced chemobrain was achieved through epigenetic induction of key factors in Wnt/-catenin and hedgehog signaling pathways mediated primarily by the most abundant secreted exosomal miRNAs (miR +genetics_GWAS 34090498 hsa-mir-21 Nerve Degeneration Halting neurodegeneration in DOX-induced chemobrain was achieved through epigenetic induction of key factors in Wnt/-catenin and hedgehog signaling pathways mediated primarily by the most abundant secreted exosomal miRNAs (miR +genetics_GWAS 34090498 hsa-mir-199a Nerve Degeneration Halting neurodegeneration in DOX-induced chemobrain was achieved through epigenetic induction of key factors in Wnt/-catenin and hedgehog signaling pathways mediated primarily by the most abundant secreted exosomal miRNAs (miR +lncRNA target 34090492 hsa-mir-375 Stomach Neoplasms mediated inhibition on GC cell stemness. +lncRNA target 34090483 hsa-mir-107 Gallbladder Neoplasms Functionally, lncRNA TTN-AS1 promoted cell viability and motility in GBC by sponging miR-107. +lncRNA target 34090463 hsa-mir-335 Ovarian Neoplasms CONCLUSION: XIST might be a carcinogenic lncRNA in ovarian cancer by regulating miR-335, and it can serve as a therapeutic target in human ovarian cancer. +lncRNA target 34090440 hsa-mir-744 Adenocarcinoma of Lung 5p inhibitor reversed the inhibitory effects of silencing LINC01116 on LAD malignant behaviors. +lncRNA target 34090323 hsa-mir-33a Carcinoma, Pancreatic Ductal CONCLUSIONS: Taken together, these results suggest that miR-33a-5p exerted tumor suppressive effects on PDAC cells by targeting RAP2A, which might provide a new theoretical basis for the clinical treatment of PDAC. +genetics_GWAS 34090052 hsa-mir-1205 Carcinoma, Hepatocellular AIM: To investigate the prophylactic efficacy of gut microbiota-based treatments on nonalcoholic steatohepatitis (NASH) management via modulation of Hippo signaling pathway-related genes (YAP1, LATS1 and NF2), and their epigenetic regulators (miR-1205 and lncRNA SRD5A3-AS1) retrieved from in-silico data analysis. +circulation_biomarker_diagnosis_ns 34089908 hsa-mir-21 Bone Diseases, Metabolic In vitro studies showed that miR-21@PSA-NP could effectively realize the intracellular delivery of miR-21 with low toxicity, while in vivo results indicated that the miR-21@PSA-NP-DSS(6) prolonged blood circulation time, enhanced bone accumulation, and significantly improved the efficacy of miR +lncRNA target 34089702 hsa-mir-633 Glioma CONCLUSION: Sevoflurane repressed glioma tumorigenesis via regulating circ_0079593/miR-633/ROCK1 axis, suggesting a new insight into the application of sevoflurane in glioma therapy. +genetics_overexpression_promote 34089591 hsa-mir-429 Hypertension Functionally, overexpression of miR-429 transgene in the renal medulla significantly improved pressure natriuretic response, enhanced urinary sodium excretion, and reduced sodium retention upon extra sodium loading, and consequently, attenuated the salt-sensitive hypertension in Dahl S rats. +genetics_overexpression_promote 34089582 hsa-mir-338 Esophageal Squamous Cell Carcinoma 5p overexpressing ESCC cells was sufficient to derepress ESCC cell invasion both in vitro and in vivo. +lncRNA target 34089461 hsa-mir-17 Acute Kidney Injury MiR5p was sponged by PVT1, and its inhibition weakened the impact of PVT1 deficiency on LPS-mediated injury of HK-2 cells. +transcription factor target 34089425 hsa-mir-373 Breast Neoplasms CONCLUSIONS: Our results prove that miRNA-373, as an oncomir, would be a vital biomarker for BC diagnosis and prognosis by targeting both VEGF and cyclin D1. +genetics_knock down_promote 34089293 hsa-mir-489 Inflammation This study revealed that shikonin protected WI-38 cells against LPS-induced cell injury and inflammatory response by regulating the miR +transcription factor target 34089082 hsa-mir-6741 Acute Kidney Injury Henceforth, this study represents and demonstrates an effective association between miR3p and kidney diseases, i.e., collapsing glomerulopathy, chronic kidney disease (CKD), acute kidney injury (AKI), and tubulointerstitial lesions susceptibility to SARS-COV-2 infection via in silico and in vitro exploration and recommended to have better insight. +circulation_biomarker_diagnosis_up 34088891 hsa-mir-21 Colorectal Neoplasms 5p expression in circulating exosomes was markedly higher in CRC patients than in healthy donors. +circulation_biomarker_diagnosis_ns 34088630 hsa-mir-199a Hypertrophy, Left Ventricular As the circulating level of miR-29a correlated with QRS duration, left ventricular hypertrophy and left atrial dilatation, the serum miR-199a level negatively correlated with corrected QT duration. +circulation_biomarker_diagnosis_up 34088630 hsa-mir-451a Hypertrophy, Left Ventricular RESULTS: Median circulating levels of miR-29a and miR-451a were significantly higher in HCM than the control group. CONCLUSIONS: The data suggested that serum levels of miR-29a and miR-451a were significantly increased in HCM patients. +circulation_biomarker_diagnosis_ns 34088630 hsa-mir-199a Cardiomyopathy, Hypertrophic As the circulating level of miR-29a correlated with QRS duration, left ventricular hypertrophy and left atrial dilatation, the serum miR-199a level negatively correlated with corrected QT duration. +circulation_biomarker_diagnosis_up 34088630 hsa-mir-29a Cardiomyopathy, Hypertrophic RESULTS: Median circulating levels of miR-29a and miR-451a were significantly higher in HCM than the control group. CONCLUSIONS: The data suggested that serum levels of miR-29a and miR-451a were significantly increased in HCM patients. +circulation_biomarker_diagnosis_up 34088630 hsa-mir-451a Cardiomyopathy, Hypertrophic RESULTS: Median circulating levels of miR-29a and miR-451a were significantly higher in HCM than the control group. CONCLUSIONS: The data suggested that serum levels of miR-29a and miR-451a were significantly increased in HCM patients. +circulation_biomarker_diagnosis_up 34088630 hsa-mir-29a Hypertrophy, Left Ventricular RESULTS: Median circulating levels of miR-29a and miR-451a were significantly higher in HCM than the control group. CONCLUSIONS: The data suggested that serum levels of miR-29a and miR-451a were significantly increased in HCM patients. +other 34088068 hsa-mir-34a Non-alcoholic Fatty Liver Disease In this study, we have investigated CdCl(2)-induced NAFLD in rats involves activation of miR34a/SIRT1/FXR axis. In conclusion, CdCl(2) induced NAFLD by increasing the transcription of miR-34a which in turn downregulates SIRT1 at the translational level. +other 34088068 hsa-mir-4 Non-alcoholic Fatty Liver Disease In this study, we have investigated CdCl(2)-induced NAFLD in rats involves activation of miR34a/SIRT1/FXR axis. In conclusion, CdCl(2) induced NAFLD by increasing the transcription of miR-34a which in turn downregulates SIRT1 at the translational level. +circulation_biomarker_prognosis_up 34087856 hsa-mir-367 Breast Neoplasms Furthermore, the relation between miR-367 in serum and clinicopathologic features and prognosis of BC patients was accessed.miR-367 expression in serum of the BC group was evidently lower than that in the control group (all P < .001). +other 34087839 hsa-mir-21 Breast Neoplasms CONCLUSION: In this study, meta-analysis and bioinformatics analysis were used to further explore the prognosis, mechanism, and related pathways of miRNA-21 in breast cancer. +lncRNA target 34087832 hsa-mir-126 Instent Restenosis METHODS: The literatures on the miRNA-126 diagnosis of ISR in CHD patients were collected by searching on computer through China National Knowledge Infrastructure, Wanfang, China Biology Medicine disc, PubMed, EMBASE, Cochrane Library and Web of Science. +lncRNA target 34087825 hsa-mir-182 Stomach Neoplasms Through bioinformatics analysis, we further discussed the mechanism of miRNA-182 in gastric cancer and the understanding of related pathways. +transcription factor target 34087588 hsa-mir-29 Fibrosis, Renal Overall, the localized delivery of cBSA/miR-29 b via a host-guest supramolecular hydrogel represents a safe and effective intervention strategy to delay and reverse the progression of interstitial renal fibrosis. +lncRNA target 34087084 hsa-mir-21 Diabetic Nephropathies 5p and upregulation of MMP9.In-silico analysis revealed MMP-9 as well as PTEN to be targets of hsa-miR +genetics_knock down_suppress 34086605 hsa-mir-92a Sveinsson Chorioretinal Atrophy In summary, the data demonstrated that AA protected against BMECs damage and TJs loss through the inhibition of miR-92a-3p expression. +genetics_knock down_promote 34086603 hsa-mir-29c Alzheimer Disease Silencing miR-29c-3p in BM-MSCs reduced BM-MSC-EV therapeutic effect on AD, which was reversed after BACE1 knockdown. +other 34086555 hsa-mir-214 Uterine Cervical Neoplasms However, miR-214 was also up-regulated in the LSIL group (p=0.0062). +circulation_biomarker_diagnosis_up 34086555 hsa-let-7a Uterine Cervical Neoplasms However, miR-let-7a was higher in HPV positive plasma samples (p=0.0433) than in HPV negative plasma samples, and the correlation analysis confirmed the association between the levels of this miRNA with the presence of HPV (p=0.0407; r=0.3029), but not with lesion grade (p>0.05). +other 34086555 hsa-mir-21 Uterine Cervical Neoplasms However, miR-214 was also up-regulated in the LSIL group (p=0.0062). +other 34086554 hsa-mir-21 Endometrial Neoplasms CONCLUSION: Our findings support the important role of miR-21 as a biomarker to diagnose endometrial cancer. +genetics_knock down_promote 34086253 hsa-mir-141 Colonic Neoplasms Knockdown of Bcl2 significantly enhanced the inhibition effect of miR +lncRNA target 34086111 hsa-mir-101 Stomach Neoplasms CONCLUSION: In summary, our results indicated that LINC00943 was correlated with gastric cancer and regulates cancer cell proliferation and chemosensitivity via hsa-miR3p. +genetics_overexpression_promote 34085707 hsa-mir-143 Colorectal Neoplasms 3p interacted with the 3' untranslated region (3'UTR) of FZD4 in CRC cells, and FZD4 overexpression partly reversed miR +circulation_biomarker_diagnosis_up 34085585 hsa-mir-155 Immune System Diseases 5p in the plasma of the Ginkgo biloba intervention group, the indicators in the serum reflecting arsenic-induced skin damage (Krt1, Krt6c, and Krt10) and the epithelial-mesenchymal transformation (EMT) vimentin were significantly reduced (P < 0.05), but the levels of NF-AT1 and the indicators reflecting arsenic-induced immunological dysfunction (IL-2, IFN-gamma) and EMT (E-cadherin) in serum were significantly increased (P < 0.05). +exosome 34085193 hsa-mir-183 Urinary Bladder Neoplasms Using quantitative real-time polymerase chain reaction; expression of exosomal microRNA (miR) +exosome 34085193 hsa-mir-96 Urinary Bladder Neoplasms Using quantitative real-time polymerase chain reaction; expression of exosomal microRNA (miR) +circulation_biomarker_diagnosis_up 34085179 hsa-mir-296 Diabetes Mellitus, Type 2 3p was downregulated in UA-induced Min6 cells and the serum of type 2 diabetes patients, while PTEN was upregulated in UA-induced Min6 cells. +other 34085163 hsa-mir-561 Arthritis, Gouty circHIPK3 sponges miR-192 and miR-561 to promote TLR4 and NLRP3 expressions, thereby promoting inflammatory response in gouty arthritis. +other 34085163 hsa-mir-192 Arthritis, Gouty circHIPK3 sponges miR-192 and miR-561 to promote TLR4 and NLRP3 expressions, thereby promoting inflammatory response in gouty arthritis. +transcription factor target 34084915 hsa-mir-200a Maternal Death We found that maternal uterine involution after delivery may involve two miRNA-target gene pairs, i.e., miRNA-200a-ZEB1 and YAP1. +lncRNA target 34084908 hsa-mir-33 Cardiovascular Diseases Our study suggests that antisense therapeutic targeting of microRNA-33 may be a potential biomarker for cardiovascular disease. +transcription factor target 34084747 hsa-mir-17 Colorectal Neoplasms We investigated 10 target miRNAs in the tissue of 28 CRC patients and identified miR-125b-5p, miR +transcription factor target 34084747 hsa-mir-17 Liver Neoplasms We investigated 10 target miRNAs in the tissue of 28 CRC patients and identified miR-125b-5p, miR +transcription factor target 34084747 hsa-mir-185 Colorectal Neoplasms We investigated 10 target miRNAs in the tissue of 28 CRC patients and identified miR-125b-5p, miR +transcription factor target 34084747 hsa-mir-185 Liver Neoplasms We investigated 10 target miRNAs in the tissue of 28 CRC patients and identified miR-125b-5p, miR +target gene 34084220 hsa-mir-224 Breast Neoplasms Long non-coding RNA CASC9/microRNA-590-3p axis participates in lutein-mediated suppression of breast cancer cell proliferation. +lncRNA target 34084218 hsa-mir-186 Uterine Cervical Neoplasms 3p expression was downregulated in cervical cancer tissues and cells, and it negatively regulated MCM2 expression by directly targeting its 3' untranslated region in cervical cancer. +other 34083664 hsa-mir-122 Carcinoma, Hepatocellular 3p in MAFLD/NASH animals was reduced with PR-PFD. +other 34083664 hsa-mir-21 Carcinoma, Hepatocellular 3p in MAFLD/NASH animals was reduced with PR-PFD. +other 34083664 hsa-mir-21 Metabolic Associated Fatty Liver Disease 3p in MAFLD/NASH animals was reduced with PR-PFD. +other 34083664 hsa-mir-122 Metabolic Associated Fatty Liver Disease 3p in MAFLD/NASH animals was reduced with PR-PFD. +other 34083664 hsa-mir-34a Carcinoma, Hepatocellular 3p in MAFLD/NASH animals was reduced with PR-PFD. +other 34083664 hsa-mir-34a Metabolic Associated Fatty Liver Disease 3p in MAFLD/NASH animals was reduced with PR-PFD. +other 34083664 hsa-mir-103 Metabolic Associated Fatty Liver Disease 3p in MAFLD/NASH animals was reduced with PR-PFD. +other 34083664 hsa-mir-103 Carcinoma, Hepatocellular 3p in MAFLD/NASH animals was reduced with PR-PFD. +other 34083573 hsa-let-7d Cardiovascular Diseases 3p, miR-133b level were significantly elevated in SS compared to IS groups. +other 34083573 hsa-mir-140 Cardiovascular Diseases 3p, miR-133b level were significantly elevated in SS compared to IS groups. +other 34083573 hsa-mir-133b Cardiovascular Diseases 3p, miR-133b level were significantly elevated in SS compared to IS groups. +other 34083573 hsa-mir-142 Cardiovascular Diseases 3p, miR-133b level were significantly elevated in SS compared to IS groups. +other 34083573 hsa-mir-199a Cardiovascular Diseases 3p, miR-133b level were significantly elevated in SS compared to IS groups. +exosome 34082869 hsa-mir-1 Squamous Cell Carcinoma of Head and Neck An exosomal RNA-seq analysis was conducted to predict regulatory exosomal miRNAs related to OSCC growth, which determined miR +lncRNA target 34082777 hsa-mir-1287 Breast Neoplasms CONCLUSION: Circ_0001982 affected BC cells glycolysis, proliferation, migration, and invasion through miR +lncRNA target 34082774 hsa-let-7a Adenomyosis If components of the hippo-YAP1 axis were unphosphorylated, upregulated let-7a could not inhibit the proliferation of ADS JZ SMCs. +genetics_GWAS 34082667 hsa-mir-7641 Rhinitis, Allergic Sequencing analysis indicated that three kinds of mutations existed in MAPK8 3'UTR, which may play a role in binding with miR-7641, and then influence the AR process. +lncRNA target 34082653 hsa-mir-106a Moebius syndrome 1 Collectively, these results revealed that miR-106a-5p inhibited the proliferative, migratory, and invasive ability of ESCs via directly binding to FOXC1, likely through the suppression of the PI3K and its downstream signaling pathway, which offered a potential and novel therapeutic strategy for EMS treatment. +other 34082653 hsa-mir-106a Endometriosis Emerging evidence has exhibited an obvious decreased expression of miR-106a-5p in the ectopic endometrial tissue of endometriosis (EMS) patients. +lncRNA target 34082648 hsa-mir-92a Breast Neoplasms In addition, BTG2 was verified as a direct miR-92a-3p target in BC cells. +exosome 34082434 hsa-mir-382 Acquired Immunodeficiency Syndrome We found that TLR3 activation of HCEs resulted in the release of exosomes that contained multiple IFN-stimulated genes (ISGs: ISG56, OAS1, MxA, and Mx2) and the HIV restriction microRNAs (miR-28, miR-29 family members, miR-125b, miR-150, miR-382, miR-223, miR-20a, and miR-198). +exosome 34082434 hsa-mir-223 Acquired Immunodeficiency Syndrome We found that TLR3 activation of HCEs resulted in the release of exosomes that contained multiple IFN-stimulated genes (ISGs: ISG56, OAS1, MxA, and Mx2) and the HIV restriction microRNAs (miR-28, miR-29 family members, miR-125b, miR-150, miR-382, miR-223, miR-20a, and miR-198). +exosome 34082434 hsa-mir-198 Acquired Immunodeficiency Syndrome We found that TLR3 activation of HCEs resulted in the release of exosomes that contained multiple IFN-stimulated genes (ISGs: ISG56, OAS1, MxA, and Mx2) and the HIV restriction microRNAs (miR-28, miR-29 family members, miR-125b, miR-150, miR-382, miR-223, miR-20a, and miR-198). +exosome 34082434 hsa-mir-28 Acquired Immunodeficiency Syndrome We found that TLR3 activation of HCEs resulted in the release of exosomes that contained multiple IFN-stimulated genes (ISGs: ISG56, OAS1, MxA, and Mx2) and the HIV restriction microRNAs (miR-28, miR-29 family members, miR-125b, miR-150, miR-382, miR-223, miR-20a, and miR-198). +exosome 34082434 hsa-mir-150 Acquired Immunodeficiency Syndrome We found that TLR3 activation of HCEs resulted in the release of exosomes that contained multiple IFN-stimulated genes (ISGs: ISG56, OAS1, MxA, and Mx2) and the HIV restriction microRNAs (miR-28, miR-29 family members, miR-125b, miR-150, miR-382, miR-223, miR-20a, and miR-198). +exosome 34082434 hsa-mir-20a Acquired Immunodeficiency Syndrome We found that TLR3 activation of HCEs resulted in the release of exosomes that contained multiple IFN-stimulated genes (ISGs: ISG56, OAS1, MxA, and Mx2) and the HIV restriction microRNAs (miR-28, miR-29 family members, miR-125b, miR-150, miR-382, miR-223, miR-20a, and miR-198). +exosome 34082434 hsa-mir-29 Acquired Immunodeficiency Syndrome We found that TLR3 activation of HCEs resulted in the release of exosomes that contained multiple IFN-stimulated genes (ISGs: ISG56, OAS1, MxA, and Mx2) and the HIV restriction microRNAs (miR-28, miR-29 family members, miR-125b, miR-150, miR-382, miR-223, miR-20a, and miR-198). +exosome 34082434 hsa-mir-125b Acquired Immunodeficiency Syndrome We found that TLR3 activation of HCEs resulted in the release of exosomes that contained multiple IFN-stimulated genes (ISGs: ISG56, OAS1, MxA, and Mx2) and the HIV restriction microRNAs (miR-28, miR-29 family members, miR-125b, miR-150, miR-382, miR-223, miR-20a, and miR-198). +transcription factor target 34082245 hsa-mir-770 Pulmonary Fibrosis Targeting miR5p might provide a new therapeutic strategy to prevent the abnormal activation of pulmonary fibroblasts in silicosis. +lncRNA target 34082012 hsa-mir-148a Carcinoma, Non-Small-Cell Lung CONCLUSION: Runx3-miR-148a-3p axis targeted YBX1 to modulate NSCLC progression. +lncRNA target 34082009 hsa-mir-503 Myocardial Reperfusion Injury CONCLUSIONS: In summary, PART1 protected mitochondrial function via miR5p/BIRC5 pathway in MI/RI, which may provide the new theoretical basis for MI/RI treatment in the clinic. +lncRNA target 34081870 hsa-mir-150 Diabetic Retinopathy The linc00174 deteriorates diabetic retinal microangiopathy via regulating miR5p/VEGFA pathway, indicating a novel therapeutic target for DR treatment. +other 34081843 hsa-mir-194 Stomach Neoplasms In particular, they show increased miR-194 levels are a predictor of more favourable gastric cancer prognosis, at least in part due to miR-194 downregulating production of a key protein for cancer development: CCND1. +other 34081808 hsa-mir-195 Osteosarcoma MicroRNA-195 (miR-195) was shown to be a suitable biomarker for osteosarcoma, and the present study describes a sensitive method of miR-195 identification by nuclease digestion in ELISA to detect and quantify the level of miR-195. This method identified miR-195 at a lower level and will help to diagnose earlier stages of osteosarcoma. +lncRNA target 34081797 hsa-mir-145 Adenocarcinoma of Lung Other experiments indicated that upregulation of each of miRNA-125a-5p or miRNA-145 inhibited cell growth, induced apoptosis, and markedly decreased the IC(50) value of erlotinib in A549 lung cancer cells (p < 0.05). The results of our study indicate that the therapeutic delivery of miRNA-145 and miRNA-125a-5p to lung cancer may inhibit cell proliferation, trigger apoptosis, and sensitize lung cancer cells to EGFR-TKIs. +lncRNA target 34081797 hsa-mir-125a Adenocarcinoma of Lung Other experiments indicated that upregulation of each of miRNA-125a-5p or miRNA-145 inhibited cell growth, induced apoptosis, and markedly decreased the IC(50) value of erlotinib in A549 lung cancer cells (p < 0.05). The results of our study indicate that the therapeutic delivery of miRNA-145 and miRNA-125a-5p to lung cancer may inhibit cell proliferation, trigger apoptosis, and sensitize lung cancer cells to EGFR-TKIs. +lncRNA target 34081624 hsa-mir-22 Cardiomyopathies 3p/Ltb4r1 signaling pathway appears to aggravate myocardial injury following a MI, which suggested that this signaling may be a useful target for improved and more individualized treatments for MI. +lncRNA target 34081624 hsa-mir-22 Myocardial Infarction, Acute 3p/Ltb4r1 signaling pathway appears to aggravate myocardial injury following a MI, which suggested that this signaling may be a useful target for improved and more individualized treatments for MI. +lncRNA target 34081622 hsa-mir-335 Colorectal Neoplasms Our findings indicate that the ZEB1-AS1-miR5p-APOC1 ceRNA regulatory network is significantly valuable for better prognosis of patients with CRC and as a new therapeutic target for the treatment of CRLM. +transcription factor target 34080953 hsa-mir-372 Epstein-Barr Virus Infections Hsa-miR5p, as well as other differential expressed miRNA, might serve as potential targets in the therapy of various EBV associated diseases. +other 34080770 hsa-mir-486 Fluorosis, Dental This study, thus, contributes significantly in revealing the mechanism of miR3p-mediated CyclinD1 upregulation in skeletal fluorosis and sheds new light on endemic fluorosis treatment. +genetics_knock down_promote 34080658 hsa-mir-181a Colorectal Neoplasms Knockdown of circNSUN2 inhibited proliferation and migration, and induced apoptosis of CRC cells and suppressed tumor growth by targeting miR181a5p to decrease ROCK2 expression. In conclusion, circNSUN2 promoted the progression of CRC by sponging miR181a5p to increase the expression of ROCK2. +other 34080652 hsa-mir-199a Lung Neoplasms The regulatory effect of miR199a5p on autophagy may provide novel insights for future multidrugresistant lung cancer chemotherapy. +transcription factor target 34080651 hsa-mir-483 Pulmonary Fibrosis In conclusion, these data indicated that miR4835p inhibition ameliorated TGFbeta1induced EMT by targeting RhoGDI1 via the Rac1/PI3K/Akt signaling pathway in PF, suggesting a potential role of miR4835p in the prevention and treatment of PF. +genetics_knock down_promote 34080649 hsa-mir-29c Parkinson Disease In addition, circSAMD4A knockdown repressed phosphorylatedAMPK expression and increased mTOR expression in MPTP or MPP(+)induced PD models, the effects of which were reversed by a miR29c3p inhibitor. +lncRNA target 34080640 hsa-mir-130b Diabetic Neuropathies On the whole, these results suggest that miR130b activates the PI3K/Akt signaling pathway to exert protective effects against oxidative stress injury via the regulation of PTEN in rats with DE. +genetics_overexpression_promote 34080639 hsa-mir-491 Colorectal Neoplasms Furthermore, LBX2AS1 overexpression could notably reverse the inhibitory effect of miR4915p on proliferation and invasion of colorectal cancer cells. +other 34080437 hsa-mir-6736 Alzheimer Disease 3p) were down-regulated in AD. +other 34080437 hsa-mir-6716 Alzheimer Disease 3p) were down-regulated in AD. +other 34080437 hsa-mir-6761 Alzheimer Disease 3p) were down-regulated in AD. +other 34080437 hsa-mir-208a Alzheimer Disease 3p) were down-regulated in AD. +other 34080437 hsa-mir-125a Alzheimer Disease 3p) were down-regulated in AD. +other 34080437 hsa-mir-24 Alzheimer Disease 3p) were down-regulated in AD. +other 34080437 hsa-mir-6754 Alzheimer Disease 3p) were down-regulated in AD. +other 34080437 hsa-mir-4747 Alzheimer Disease 3p) were down-regulated in AD. +other 34080437 hsa-mir-6778 Alzheimer Disease 3p) were down-regulated in AD. +other 34080437 hsa-mir-6740 Alzheimer Disease 3p) were down-regulated in AD. +other 34080437 hsa-mir-125b-1 Alzheimer Disease 3p) were down-regulated in AD. +other 34080437 hsa-mir-6753 Alzheimer Disease 3p) were down-regulated in AD. +other 34080437 hsa-mir-595 Alzheimer Disease 3p) were down-regulated in AD. +other 34080437 hsa-mir-6875 Alzheimer Disease 3p) were down-regulated in AD. +other 34080437 hsa-mir-6762 Alzheimer Disease 3p) were down-regulated in AD. +other 34080437 hsa-mir-6787 Alzheimer Disease 3p) were down-regulated in AD. +other 34080437 hsa-mir-4435 Alzheimer Disease 3p) were down-regulated in AD. +other 34080437 hsa-mir-22 Alzheimer Disease 3p) were down-regulated in AD. +other 34080437 hsa-mir-6131 Alzheimer Disease 3p) were down-regulated in AD. +other 34080437 hsa-mir-6747 Alzheimer Disease 3p) were down-regulated in AD. +other 34080437 hsa-mir-646 Alzheimer Disease 3p) were down-regulated in AD. +circulation_biomarker_diagnosis_up 34080404 hsa-mir-425 Pneumonia Our results showed that miR-425, miR-155 and miR-33 were up-regulated in the serum from CAP patients when compared to healthy controls; whereas there was no significant difference in serum miR-222, miR-149, miR-186 and miR-132 expression levels between healthy controls and CAP patients. In conclusion, our results showed that miR-425, miR-155 and miR-33 were up-regulated in the serum from CAP patients by using bioinformatics analysis and experimental validation; furthermore, miR-425, miR-155 and miR-33 inhibition attenuated LPS-induced inflammatory responses in RAW264.7 cells. +circulation_biomarker_diagnosis_up 34080404 hsa-mir-155 Pneumonia Our results showed that miR-425, miR-155 and miR-33 were up-regulated in the serum from CAP patients when compared to healthy controls; whereas there was no significant difference in serum miR-222, miR-149, miR-186 and miR-132 expression levels between healthy controls and CAP patients. In conclusion, our results showed that miR-425, miR-155 and miR-33 were up-regulated in the serum from CAP patients by using bioinformatics analysis and experimental validation; furthermore, miR-425, miR-155 and miR-33 inhibition attenuated LPS-induced inflammatory responses in RAW264.7 cells. +circulation_biomarker_diagnosis_up 34080404 hsa-mir-3 Pneumonia Our results showed that miR-425, miR-155 and miR-33 were up-regulated in the serum from CAP patients when compared to healthy controls; whereas there was no significant difference in serum miR-222, miR-149, miR-186 and miR-132 expression levels between healthy controls and CAP patients. In conclusion, our results showed that miR-425, miR-155 and miR-33 were up-regulated in the serum from CAP patients by using bioinformatics analysis and experimental validation; furthermore, miR-425, miR-155 and miR-33 inhibition attenuated LPS-induced inflammatory responses in RAW264.7 cells. +lncRNA target 34080033 hsa-mir-335 Retinoblastoma These data suggested that the long noncoding RNA SNHG20 may promote cell proliferation, migration and invasion in RB via the miR3355p/E2F3 axis. +genetics_overexpression_promote 34080031 hsa-mir-875 Carcinoma, Non-Small-Cell Lung Notably, it was determined that special ATrich sequencebinding protein 2 (SATB2) was a direct target gene of miR875, and overexpression of miR875 largely abrogated the effects of HCG11 in NSCLC cells. In conclusion, HCG11 was shown to suppress the malignant properties of NSCLC cells by targeting a miR875/SATB2 axis, and may therefore be a promising target for the treatment of NSCLC. +genetics_overexpression_promote 34080029 hsa-mir-454 Uterine Cervical Neoplasms In conclusion, the present study indicated that ILF3AS1 inhibited CC cell proliferation and migration, and promoted CC cell apoptosis by inhibiting epithelialmesenchymal transition, and ILF3AS1 overexpression partially reversed the inhibitory effect of miR4543p on PTEN expression. +lncRNA target 34080028 hsa-mir-181a Myocardial Infarction These results provided a novel mechanistic insight into the role of ANRIL in H/Rinjured cardiomyocytes and suggested that the ANRIL/miR181a/SIRT1 axis may be a therapeutic target for reducing MI/R injury. +lncRNA target 34080023 hsa-mir-204 Hepatoblastoma In summary, TUG1 was upregulated in hepatoblastoma and suppressed miR2045p, thereby activating the downstream signalling pathway of JAK2/STAT3 to facilitate angiogenesis. +lncRNA target 34079820 hsa-mir-200b Esophageal Diseases Collectively, this study suggests that MMC inhibited esophageal fibrosis by regulating cell apoptosis and autophagy via downregulating lncRNA-ATB and upregulating miR-200b. +lncRNA target 34079762 hsa-mir-1258 Glioblastoma Furthermore, restoration of E2F1 expression in GBM cells effectively rescued the tumor-suppressive effect of miR-1258. +circRNA target 34079759 hsa-mir-20 Glioblastoma Collectively, our findings showed that the circHECTD1-miR5p-SLC2A1 regulatory pathway promoted the progression of GBM, suggesting that circHECTD1 may be a therapeutic target for GBM. +genetics_knock down_promote 34079594 hsa-mir-499a Leukemia, Myeloid, Acute Knockdown of miR-499a-5p suppressed AML cell proliferation and promoted AML cell apoptosis, but silencing PDCD4 abolished this effect. +lncRNA target 34079592 hsa-mir-214 Colorectal Neoplasms Inhibition of miR +genetics_overexpression_suppress 34079591 hsa-mir-590 pancreatic adenocarcinoma In addition, overexpression of miR +lncRNA target 34079084 hsa-mir-654 Breast Neoplasms In conclusion, our findings reveal that Lnc-408 promotes BC invasion and metastasis via the Lnc-408/miR5p/LIMK1 axis, highlighting a novel promising target for the diagnosis and treatment of BC. +transcription factor target 34079082 hsa-mir-26b Lung Neoplasms In the present study, we revealed that GPC5 transcriptionally enhanced the expression of CTDSP1 (miR-26b host gene) via AhR-ARNT pathway, and such up-regulation of CTDSP1 intracellularly contributed to the inhibited proliferation of lung cancer cells. By uncovering the regulation network among GPC5, miR-26b, miR-26b host gene (CTDSP1), and target gene (PTK2), our findings demonstrated that GPC5 functioned as a tumor suppressor in human lung cancer. +transcription factor target 34078833 hsa-mir-205 Myocardial Reperfusion Injury In conclusion, miR-205 might participate in the protective effect of remifentanil in rat myocardial I/R injury via regulation of PINK1, providing a potential target for amelioration of cardiovascular ischemic disease. +transcription factor target 34078799 hsa-mir-135 Myocardial Infarction Overall, miR-135a promotes ISO-induced cardiac injury by inhibiting the TLR4 pathway. +transcription factor target 34078799 hsa-mir-135a Myocardial Infarction Overall, miR-135a promotes ISO-induced cardiac injury by inhibiting the TLR4 pathway. +lncRNA target 34078755 hsa-mir-4270 Nasopharyngeal Carcinoma In conclusion, this study first reports that miR-4270 is lower in the radio-sensitive patients and modulated the irradiation-sensitivity of nasopharyngeal carcinoma cells through modulation of p53 in vivo. +lncRNA target 34078519 hsa-mir-877 Stomach Diseases 5p may be a potential therapeutic target for gastric mucosal injury caused by aspirin. +genetics_overexpression_promote 34078414 hsa-mir-200b Ovarian Neoplasms miR-200b-overexpressed macrophages-conditioned medium notably enhanced the cell viability and invasion of ovarian cancer cells. +transcription factor target 34078310 hsa-mir-15a Stomach Neoplasms CONCLUSIONS: Collectively, these results suggest that LINC_00355 promotes GC progression by up-regulating PHF19 through sponging miR-15a-5p. +transcription factor target 34078216 hsa-mir-409 Parkinson Disease The current study demonstrated that the inhibition of miR +genetics_knock down_promote 34077824 hsa-mir-18a Intracranial Hemorrhages Conversely, miR-18a knockdown or RUNX1 overexpression just presented an improvement effect on ICH. +circRNA target 34077501 hsa-mir-182 Sepsis Our data suggested that circ_0091702 sponged miR-182 to regulate PDE7A, thereby alleviating LPS-induced cell injury in sepsis. +other 34077450 hsa-mir-122 Diabetes Mellitus, Type 2 3p and miRNA-146a levels were lower in T2DM and pre-diabetic patients compared to control (p<0.05). +other 34077450 hsa-mir-126 Diabetes Mellitus, Type 2 3p and miRNA-146a levels were lower in T2DM and pre-diabetic patients compared to control (p<0.05). +other 34077450 hsa-mir-146a Diabetes Mellitus, Type 2 3p and miRNA-146a levels were lower in T2DM and pre-diabetic patients compared to control (p<0.05). +genetics_knock down_promote 34077306 hsa-mir-1298 Carcinoma, Non-Small-Cell Lung Taken together, circ_0003028 knockdown could suppress NSCLC progression partly by regulating the miR +lncRNA target 34077295 hsa-mir-515 Glioma In conclusion, this study corroborated the regulatory mechanism of SP1/ZFPM2-AS1/miR5p/SOD2 axis in glioma, indicating that targeting ZFPM2-AS1 might be an effective way to treat glioma. +lncRNA target 34077011 hsa-mir-505 Osteosarcoma 5p is raised significantly in the cancer tissues of osteosarcoma patients, and the inhibition of miR +lncRNA target 34077008 hsa-mir-223 Lymphoma, Large B-Cell, Diffuse CONCLUSIONS: MiR-223 may suppress the proliferation and promote the apoptosis of DLBCL c. +genetics_overexpression_promote 34077004 hsa-mir-326 Ovarian Neoplasms MiR-326 overexpression markedly restrained the proliferation and invasion of OC cells, whereas miR-326 inhibitors exerted the contrary effect. +genetics_overexpression_promote 34077002 hsa-mir-326 Colorectal Neoplasms RESULTS: miR-326 overexpression significantly inhibited the viability, invasion and migration and promoted the apoptosis of CRC cells, but overexpression of both E2F1 and miR-326 in turn increased cell viability, invasion and migration and decreased cell apoptosis. +circulation_biomarker_diagnosis_ns 34076996 hsa-mir-614 Stomach Neoplasms PURPOSE: To investigate the expression of miR-614 in serum of gastric cancer patients and its effect on invasion and proliferation of gastric cancer cell line HGC-27. CONCLUSION: In conclusion, miR-614 is lowly expressed in gastric cancer patients and inhibits the invasion and proliferation of gastric cancer cell line HGC-27. +circulation_biomarker_prognosis_up 34076989 hsa-mir-203 Carcinoma, Hepatocellular CONCLUSIONS: Serum level of miRNA-203 is downregulated in HCC patients, which is upregulated following TACE. +genetics_overexpression_promote 34076988 hsa-mir-497 Carcinoma, Hepatocellular CONCLUSION: miR-497 was lowly expressed in HCC tissues, and its overexpression inhibited invasion and metastasis in HCC cells by suppressing VEGF-B levels. +other 34076987 hsa-mir-182 Carcinoma, Hepatocellular 5p were markedly downregulated in LIHC tissues. +lncRNA target 34076987 hsa-mir-22 Carcinoma, Hepatocellular 3p suppresses proliferative ability and arrests cell cycle progression in HCC through targeting CDKN2C. +genetics_overexpression_suppress 34076980 hsa-mir-188 Glioma Overexpression of miRNA +lncRNA target 34076978 hsa-mir-335 Carcinoma, Non-Small-Cell Lung PURPOSE: The purpose of this study was to illustrate the role of long non-coding RNA (lncRNA) NEAT1 in inhibiting sorafenib sensitivity in non-small cell lung cancer (NSCLC) through targeting microRNA-335 (miR-335)/c-Met axis. CONCLUSIONS: LncRNA NEAT1 aggravates sorafenib resistance in NSCLC through inhibiting MiR-335 to upregulate c-Met level, manifesting as attenuated proliferation and accelerated apoptosis. +other 34076850 hsa-mir-17 End Stage Liver Disease Levels of miR-17 were remarkably higher in recipients with alcoholic ESLD. +other 34076840 hsa-mir-27a Sepsis Our results suggested that Linc-KIAA1737-2 could promote LPS-induced apoptosis in HK-2 cells, and presumably sepsis-induced acute kidney injury, by regulating the miR-27a-3p/TLR4/NF-kappaB axis. +other 34076840 hsa-mir-27a Acute Kidney Injury Our results suggested that Linc-KIAA1737-2 could promote LPS-induced apoptosis in HK-2 cells, and presumably sepsis-induced acute kidney injury, by regulating the miR-27a-3p/TLR4/NF-kappaB axis. +transcription factor target 34076811 hsa-mir-181b Sepsis This present study suggests that miR-181b decreased inflammatory factors and reduced myocardial injury in sepsis through downregulation of HMGB1. +transcription factor target 34076811 hsa-mir-181b Myocardial Infarction This present study suggests that miR-181b decreased inflammatory factors and reduced myocardial injury in sepsis through downregulation of HMGB1. +circulation_biomarker_diagnosis_ns 34076790 hsa-mir-150 Carcinoma, Endometrioid We aim to assess serum expression of miRNA 27a and miRNA150-5p in endometrial cancer patients. +other 34076790 hsa-mir-27a Carcinoma, Endometrioid miRNA 27a was significantly associated with type I endometroid endometrial cancer. +epigenetics 34076365 hsa-mir-93 Osteoarthritis RESULTS: Circ_HECW2 and miR-93 were inversely correlated, with Circ_HECW2 upregulated and miR-93 downregulated in OA and LPS-induced chondrocytes. CONCLUSION: In summary, our data revealed that the Circ_HECW2 is highly expressed in OA and might inhibit miR-93 expression through methylation to affect LPS-induced chondrocyte apoptosis. +genetics_knock down_promote 34076278 hsa-mir-184 Stomach Neoplasms Also, FOSB knockdown offset the suppressive impact of miR-184 silencing on GC cell malignancy. +lncRNA target 34076140 hsa-mir-92b Carcinoma, Hepatocellular Furthermore, we confirmed by western blotting and immunofluorescence that miR-92b can mediate sorafenib resistance by activating the PI3K/AKT/mTOR pathway in HCC cells by directly targeting PTEN. +genetics_knock down_suppress 34075147 hsa-mir-148a Breast Neoplasms Here, we performed a knockdown of miR-148a using anti-miRNA oligonucleotides (AMOs) and investigated the effect on BC cell proliferation. +lncRNA target 34075120 hsa-mir-155 Autoimmune Diseases MicroRNA miR-155 is an important regulatory molecule in the immune system and is highly expressed and functional in Th17 cells, a subset of CD4(+) T helper cells which are key players in autoimmune diseases. Small molecules that can modulate miR-155 may potentially provide new therapeutic avenues to inhibit Th17 cell-mediated autoimmune diseases. +other 34075120 hsa-mir-155 Dermatitis, Atopic In addition, we found that FDA approved antiparasitic agents belonging to the 'azole' family also down-regulate Mir155 reporter and cytokine expression in Th17 cells, and thus could potentially be repurposed to treat Th17-driven immunopathologies. +transcription factor target 34075026 hsa-mir-5000 Colorectal Neoplasms Moreover, through in vitro and in vivo experiments, miR +circulation_biomarker_diagnosis_ns 34074816 hsa-mir-127 Acquired Immunodeficiency Syndrome 5p to motor function, miRNAs previously identified in CSF or plasma in Alzheimer's and Parkinson's, respectively. +circulation_biomarker_diagnosis_ns 34074816 hsa-mir-485 Acquired Immunodeficiency Syndrome 5p to motor function, miRNAs previously identified in CSF or plasma in Alzheimer's and Parkinson's, respectively. +circulation_biomarker_diagnosis_up 34074322 hsa-mir-1 Adenocarcinoma of Lung Furthermore, higher levels of circulating exosomal miR +lncRNA target 34073426 hsa-mir-146a Colonic Neoplasms A qRT-PCR validation step was conducted in a COAD patient cohort comprising of 29 tumor tissues and 29 normal adjacent tissues, endorsing the expression level for BMP5, as well as for two of the miRNAs targeting key EMT related genes, revealing upregulation of miR-27a-5p and miR-146a-5p. +lncRNA target 34073426 hsa-mir-27a Colonic Neoplasms A qRT-PCR validation step was conducted in a COAD patient cohort comprising of 29 tumor tissues and 29 normal adjacent tissues, endorsing the expression level for BMP5, as well as for two of the miRNAs targeting key EMT related genes, revealing upregulation of miR-27a-5p and miR-146a-5p. +other 34073154 hsa-mir-126 Prediabetic State 3p could potentially contribute to diabetes risk screening strategies. +other 34073090 hsa-mir-106a Osteoarthritis In OA chondrocytes miR-106a, miR-27a, miR-34b, miR-365a and miR-424 were downregulated. +other 34073090 hsa-mir-424 Osteoarthritis In OA chondrocytes miR-106a, miR-27a, miR-34b, miR-365a and miR-424 were downregulated. +other 34073090 hsa-mir-365a Osteoarthritis In OA chondrocytes miR-106a, miR-27a, miR-34b, miR-365a and miR-424 were downregulated. +transcription factor target 34073090 hsa-mir-365a Neoplasms, Second Primary miR-365a-5p is known to directly target HDAC and NF-kB, and a decrease in HDAC activity by NMRT was detected. +other 34073090 hsa-mir-27a Osteoarthritis In OA chondrocytes miR-106a, miR-27a, miR-34b, miR-365a and miR-424 were downregulated. +other 34073090 hsa-mir-34b Osteoarthritis In OA chondrocytes miR-106a, miR-27a, miR-34b, miR-365a and miR-424 were downregulated. +lncRNA target 34072442 hsa-mir-34a Triple Negative Breast Neoplasms Our data form a solid foundation for promoting the use of a miR-34a-based approach to improve the therapeutic efficacy of selinexor in TNBC patients. +other 34071966 hsa-mir-122 Liver Diseases miR5p can be used as a characteristic miRNA of UAB and may help to improve liver- and brain-related diseases. +other 34071966 hsa-mir-423 Muscular Diseases Further analysis revealed that miR-423 can be used as a characteristic miRNA of UVB and has the potential to treat muscle-related diseases. +lncRNA target 34071861 hsa-mir-200c Ovarian Neoplasms, High-Grade Serous We identified the upregulation of miR-200c-3p expression in different stages of HGSC clinical samples and the downregulation of the tumor suppressor gene, Deleted in Liver Cancer 1 (DLC1), expression. +lncRNA target 34071707 hsa-mir-122 Cardiomyopathies The downmodulation of cardiac Cx43, Cx26 and miR-122, high pS368-Cx43 phosphorylation, cell viability and survival activation could represent some of the female adaptative/compensatory reactions to ponatinib cardiotoxicity. +lncRNA target 34071592 hsa-mir-361 Pulmonary Disease, Chronic Obstructive 5p; 14 miRNAs were significantly dysregulated between lung cancer and stable COPD participants, with the greatest single miRNA being miR-27a-3p (AUC 0.803), with two other miRNAs (miR-106b-3p and miR +lncRNA target 34071592 hsa-mir-106b Lung Neoplasms 5p; 14 miRNAs were significantly dysregulated between lung cancer and stable COPD participants, with the greatest single miRNA being miR-27a-3p (AUC 0.803), with two other miRNAs (miR-106b-3p and miR +lncRNA target 34071592 hsa-mir-497 Pulmonary Disease, Chronic Obstructive 5p; 14 miRNAs were significantly dysregulated between lung cancer and stable COPD participants, with the greatest single miRNA being miR-27a-3p (AUC 0.803), with two other miRNAs (miR-106b-3p and miR +lncRNA target 34071592 hsa-mir-497 Lung Neoplasms 5p; 14 miRNAs were significantly dysregulated between lung cancer and stable COPD participants, with the greatest single miRNA being miR-27a-3p (AUC 0.803), with two other miRNAs (miR-106b-3p and miR +lncRNA target 34071592 hsa-mir-361 Lung Neoplasms 5p; 14 miRNAs were significantly dysregulated between lung cancer and stable COPD participants, with the greatest single miRNA being miR-27a-3p (AUC 0.803), with two other miRNAs (miR-106b-3p and miR +lncRNA target 34071592 hsa-mir-27a Lung Neoplasms 5p; 14 miRNAs were significantly dysregulated between lung cancer and stable COPD participants, with the greatest single miRNA being miR-27a-3p (AUC 0.803), with two other miRNAs (miR-106b-3p and miR +lncRNA target 34071592 hsa-mir-27a Pulmonary Disease, Chronic Obstructive 5p; 14 miRNAs were significantly dysregulated between lung cancer and stable COPD participants, with the greatest single miRNA being miR-27a-3p (AUC 0.803), with two other miRNAs (miR-106b-3p and miR +lncRNA target 34071592 hsa-mir-106b Pulmonary Disease, Chronic Obstructive 5p; 14 miRNAs were significantly dysregulated between lung cancer and stable COPD participants, with the greatest single miRNA being miR-27a-3p (AUC 0.803), with two other miRNAs (miR-106b-3p and miR +exosome 34071504 hsa-mir-643 Carcinoma, Hepatocellular The present study was designed to identify the role of miR-643, which is one of the most significantly increased miRNA in exosomes released from cisplatin-resistant Heptocarcinoma cells, in altering the cisplatin resistance properties of recipient cells. +other 34071189 hsa-mir-126 Diabetes Mellitus, Type 2 MiR-126 Is an Independent Predictor of Long-Term All-Cause Mortality in Patients with Type 2 Diabetes Mellitus. To conclude, miR-126 expression is a strong and independent predictor of long-term all-cause mortality among patients with T2DM. +other 34070923 hsa-mir-106b Colorectal Neoplasms Thus, miR-106b/NR2F2-AS1/PLEKHO2/MAPK signaling axis may suggest the potential usage in CRC treatment. +lncRNA target 34070538 hsa-mir-139 Breast Neoplasms mediated suppression of CXCR4/p-Akt signaling and thereby affected mesenchymal stem-cell genesis, indicating its potential as a therapeutic target for invasive breast cancer. +lncRNA target 34070455 hsa-mir-491 Chondrosarcoma 5p, and also Bcl-xL as a direct target of both miR +circulation_biomarker_diagnosis_ns 34070163 hsa-mir-1270 Pre-Eclampsia Hsa-miR-1270 showed significantly different levels in cord blood EPC from preeclampsia versus control and was negatively correlated with mRNA levels of its predicted targets ANGPTL7 and TFRC. +circulation_biomarker_prognosis_ns 34069692 hsa-mir-16 Liver Cirrhosis Our results emphasized that exosomes secreted into the plasma carry differentially expressed miRNAs of which in particular, miR-192, miR-146, and miR-16 are promising diagnostic and prognostic markers for both HCC and liver cirrhosis patients. +circulation_biomarker_prognosis_ns 34069692 hsa-mir-16 Carcinoma, Hepatocellular Our results emphasized that exosomes secreted into the plasma carry differentially expressed miRNAs of which in particular, miR-192, miR-146, and miR-16 are promising diagnostic and prognostic markers for both HCC and liver cirrhosis patients. +other 34069135 hsa-mir-205 Breast Neoplasms 5p are expressed and released by BC cells, endothelial cells and during their interaction. +other 34069135 hsa-mir-194 Triple Negative Breast Neoplasms 5p are expressed and released by BC cells, endothelial cells and during their interaction. +other 34069135 hsa-mir-194 Breast Neoplasms 5p are expressed and released by BC cells, endothelial cells and during their interaction. +other 34069135 hsa-mir-205 Triple Negative Breast Neoplasms 5p are expressed and released by BC cells, endothelial cells and during their interaction. +target gene 34069116 hsa-mir-122 Carcinoma, Hepatocellular Histone Methyltransferase G9a-Promoted Progression of Hepatocellular Carcinoma Is Targeted by Liver-Specific Hsa-miR-122. +circulation_biomarker_diagnosis_up 34069089 hsa-mir-615 Breast Neoplasms 3p in the serum of patients with BC. +other 34069007 hsa-mir-181a pancreatic adenocarcinoma In situ hybridization of miR-181a and immunohistochemistry of EPB41L4B and SEL1L in pancreatic tissues (n = 4 Healthy; n = 3 IPMN; n = 4 PDAC) were also carried out. +other 34069007 hsa-mir-181a Carcinoma, Pancreatic Ductal In situ hybridization of miR-181a and immunohistochemistry of EPB41L4B and SEL1L in pancreatic tissues (n = 4 Healthy; n = 3 IPMN; n = 4 PDAC) were also carried out. +transcription factor target 34068941 hsa-mir-27b Fibrosis, Renal In conclusion, we suggest that selective inhibition of K63-Ub, when combined with the conventional treatment with ACE inhibitors, might represent a novel treatment strategy to prevent the progression of fibrosis and proteinuria in diabetic nephropathy and we propose miR-27b-3p as a biomarker of treatment efficacy. +transcription factor target 34068941 hsa-mir-27b Diabetes Mellitus, Type 2 In conclusion, we suggest that selective inhibition of K63-Ub, when combined with the conventional treatment with ACE inhibitors, might represent a novel treatment strategy to prevent the progression of fibrosis and proteinuria in diabetic nephropathy and we propose miR-27b-3p as a biomarker of treatment efficacy. +other 34068397 hsa-mir-1228 Uterine Cervical Neoplasms 5p and increased levels of miR-146a-3p in patients with EP revealed unresolved inflammation, with accompanying increased expression of PCK1 and decreased expression of FCGR1A. +other 34068397 hsa-mir-33a Uterine Cervical Neoplasms 5p and increased levels of miR-146a-3p in patients with EP revealed unresolved inflammation, with accompanying increased expression of PCK1 and decreased expression of FCGR1A. +other 34068397 hsa-mir-146a Uterine Cervical Neoplasms 5p and increased levels of miR-146a-3p in patients with EP revealed unresolved inflammation, with accompanying increased expression of PCK1 and decreased expression of FCGR1A. +other 34068397 hsa-mir-3200 Uterine Cervical Neoplasms 5p and increased levels of miR-146a-3p in patients with EP revealed unresolved inflammation, with accompanying increased expression of PCK1 and decreased expression of FCGR1A. +other 34068397 hsa-mir-6815 Uterine Cervical Neoplasms 5p and increased levels of miR-146a-3p in patients with EP revealed unresolved inflammation, with accompanying increased expression of PCK1 and decreased expression of FCGR1A. +genetics_GWAS 34068078 hsa-mir-15a Leukemia, Myeloid, Acute MiR-15a-5p overexpression in AML cells reduced apoptosis induced by both drugs in vitro. +other 34067956 hsa-mir-6782 Testicular Germ Cell Tumor RT-qPCR validated hsa-miR5p to be present at 2.3-fold lower levels (p = 0.02) in the SP from men with TGCTs compared with controls. +circulation_biomarker_diagnosis_up 34067683 hsa-mir-421 Diabetes Mellitus, Type 2 Among them, miR-421 level was found to be decreased in the serum of diabetic patients, regardless of the presence or absence of diabetic complications, as well as being differential in various body mass index (BMI) groups. +other 34067335 hsa-mir-6798 Pancreatic Intraductal Neoplasms 5p) in IPMC were significantly enriched compared to those in IPMA. +other 34067335 hsa-mir-6780b Pancreatic Intraductal Neoplasms 5p) in IPMC were significantly enriched compared to those in IPMA. +other 34067335 hsa-mir-679 Pancreatic Carcinoma 5p) in IPMC were significantly enriched compared to those in IPMA. +other 34067335 hsa-mir-6879 Pancreatic Carcinoma 5p) in IPMC were significantly enriched compared to those in IPMA. +other 34067335 hsa-mir-6780b Pancreatic Carcinoma 5p) in IPMC were significantly enriched compared to those in IPMA. +other 34067335 hsa-mir-6798 Pancreatic Carcinoma 5p) in IPMC were significantly enriched compared to those in IPMA. +other 34067335 hsa-mir-6879 Pancreatic Intraductal Neoplasms 5p) in IPMC were significantly enriched compared to those in IPMA. +other 34067335 hsa-mir-6126 Pancreatic Intraductal Neoplasms 5p) in IPMC were significantly enriched compared to those in IPMA. +other 34067335 hsa-mir-679 Pancreatic Intraductal Neoplasms 5p) in IPMC were significantly enriched compared to those in IPMA. +other 34067335 hsa-mir-711 Pancreatic Intraductal Neoplasms 5p) in IPMC were significantly enriched compared to those in IPMA. +other 34067335 hsa-mir-711 Pancreatic Carcinoma 5p) in IPMC were significantly enriched compared to those in IPMA. +other 34067335 hsa-mir-6126 Pancreatic Carcinoma 5p) in IPMC were significantly enriched compared to those in IPMA. +transcription factor target 34067060 hsa-mir-200c Myocardial Infarction Interestingly, we also found a significant upregulation of Follistatin-related protein 1 (FSTL1), a miR-200c predicted target already identified as a potent cardiogenic factor produced by epicardial cells that promotes regeneration following MI. +genetics_GWAS 34066331 hsa-mir-125b Colonic Neoplasms In conclusion, our data show that miR-125b-5p has an anti-cancer effect only in TP53 mutated colon cancer cells, explaining partially the dual behavior of this microRNA in malignant pathologies. +other 34063883 hsa-mir-378a Diabetes Mellitus These alterations correlated with a decrease in ATGL and Pgc1b expression in the OB group and with an increase of miR-378a-3p levels in the OBD group. +other 34063883 hsa-mir-378a Obesity These alterations correlated with a decrease in ATGL and Pgc1b expression in the OB group and with an increase of miR-378a-3p levels in the OBD group. +other 34063878 hsa-mir-125b-2 Glaucoma, Open-Angle 3p, and the miR-27a-3p. +other 34063878 hsa-mir-224 Ocular Hypertension 3p, and the miR-27a-3p. +other 34063878 hsa-mir-151a Glaucoma, Open-Angle 3p, and the miR-27a-3p. +other 34063878 hsa-mir-151a Ocular Hypertension 3p, and the miR-27a-3p. +other 34063878 hsa-mir-1307 Ocular Hypertension 3p, and the miR-27a-3p. +other 34063878 hsa-mir-224 Glaucoma, Open-Angle 3p, and the miR-27a-3p. +other 34063878 hsa-mir-27a Ocular Hypertension 3p, and the miR-27a-3p. +other 34063878 hsa-mir-1307 Glaucoma, Open-Angle 3p, and the miR-27a-3p. +other 34063878 hsa-mir-125b-2 Ocular Hypertension 3p, and the miR-27a-3p. +other 34063878 hsa-mir-27a Glaucoma, Open-Angle 3p, and the miR-27a-3p. +other 34063705 hsa-mir-141 Colorectal Neoplasms In our study, the detection and expression of miR-141 in a cohort of colorectal cancer (n = 6) and breast cancer (n = 4) samples showed that its levels were significantly higher than in a healthy cohort (n = 9) (p < 0.004). +other 34063705 hsa-mir-141 Bulimia Nervosa In light of this, we aimed to develop a high-sensitivity microRNA (miR) biosensor for application in the diagnosis of all miRassociated cancers, such as colorectal cancer (CRC) and breast cancer (BC). +other 34063705 hsa-mir-141 Breast Neoplasms In our study, the detection and expression of miR-141 in a cohort of colorectal cancer (n = 6) and breast cancer (n = 4) samples showed that its levels were significantly higher than in a healthy cohort (n = 9) (p < 0.004). +genetics_overexpression_promote 34063443 hsa-mir-129 Melanoma 5p acts as a tumor suppressor as its overexpression decreased cell proliferation, improved treatment response and reduced viability of BRAFi resistant melanoma cells. +circulation_biomarker_diagnosis_ns 34063140 hsa-mir-148b Glomerulonephritis, IGA Serum levels of miR-148b, let-7b, and galactose-deficient IgA1 (Gd-IgA1) at the time of diagnosis were measured using real-time quantitative PCR and enzyme-linked immunosorbent assay using the monoclonal antibody KM55, respectively. +circulation_biomarker_diagnosis_ns 34063140 hsa-mir-148 Glomerulonephritis, IGA Serum levels of miR-148b, let-7b, and galactose-deficient IgA1 (Gd-IgA1) at the time of diagnosis were measured using real-time quantitative PCR and enzyme-linked immunosorbent assay using the monoclonal antibody KM55, respectively. +other 34063140 hsa-let-7b Glomerulonephritis, IGA Patients with fast progression of the renal damage had significantly increased levels of let-7b (p = 0.01), Model 1 (p = 0.003), and Model 2 (p = 0.005) compared to slow progressors, as did those who reached ESKD (p = 0.002, p = 0.001, and p = 0.001, respectively). +other 34062414 hsa-mir-605 Complex Regional Pain Syndromes We hypothesized that downregulation of miR-605 in poor responders to ketamine could increase CXCL5 expression and thereby contribute to inflammation in these patients. Thus, our studies suggest that miR-605 regulation of CXCL5 can regulate inflammation. +circulation_biomarker_diagnosis_ns 34062189 hsa-mir-20a limb ischemia The expression of MALAT1 and miR-320a was correlated with the changes of morphological and blood indices in obese children, and their correlations with endothelial dysfunction markers were obtained. +circulation_biomarker_diagnosis_ns 34062189 hsa-mir-20a Obesity The expression of MALAT1 and miR-320a was correlated with the changes of morphological and blood indices in obese children, and their correlations with endothelial dysfunction markers were obtained. +circulation_biomarker_diagnosis_ns 34062187 hsa-mir-19a Glioblastoma METHODS: Here we compared the expression of EGFR, miR-34a, and miR-19a between tumoral and adjacent non-cancerous tissues (ANCTs) of 50 GBM patients and also compared their expression levels in serum samples of GBM patients with serum samples of 50 control subjects. +circulation_biomarker_diagnosis_down 34062187 hsa-mir-34a Glioblastoma CONCLUSIONS: Dysregulation of the EGFR gene and miR-34a in serum samples of GBM patients compared with the control subjects promises the emergence of non-invasive biomarkers for early detection of GBM which need confirmative studies with a large sample size. +lncRNA target 34062164 hsa-mir-211 Depression 5p within the DG area in CUMS rats promoted neuronal neurogenesis, reduced neuronal apoptosis via suppression of the Dyrk1A/STAT3 signaling pathway and relieved depression-like behaviors in these CUMS rats. +lncRNA target 34062049 hsa-mir-9 Squamous Cell Carcinoma of Head and Neck miR-9 modulates and predicts the response to radiotherapy and EGFR inhibition in HNSCC. +genetics_overexpression_suppress 34062009 hsa-mir-506 Triple Negative Breast Neoplasms The results confirmed that overexpression of miR-506 and PENK in vivo through loading on GNs inhibited in situ triple-negative breast tumor growth and metastasis significantly in the xenograft model. +genetics_overexpression_suppress 34061466 hsa-mir-106a Adenocarcinoma of Lung To verify the relationship between SGMS1-AS1, miR-106a-5p, and MYLIP, we overexpressed miR-106a-5p inhibitor or MYLIP in LUAD cells after decreasing SGMS1-AS1 and repeated the above assays. +lncRNA target 34061447 hsa-mir-103a Arthritis, Rheumatoid CONCLUSION: Our data suggested that the linc00152/NF-kappaB feedback loop promotes RAFLS inflammation via regulating miR-103a/TAK1 axis and YY1 expression. +genetics_overexpression_suppress 34061329 hsa-mir-620 Breast Neoplasms MiR-620 inhibitor hindered BC cell progression, which was similar to the effect of circ_0001666 overexpression. CONCLUSION: Circ_0001666 hindered the progression of BC via miR-620/WNK2 axis. +other 34061272 hsa-mir-383 Glomerulonephritis, IGA miR-383 level was decreased in IgAN samples compared to healthy subject. In addition, miR-383 expression was also lower in urinary of IgAN cases than in urinary of healthy control. +transcription factor target 34061013 hsa-mir-28 Triple Negative Breast Neoplasms OBJECTIVE: Using MDA-MB-231 cells as a model system for TNBC, we hypothesized that DHT would induce cell sensitivity towards doxorubicin via increasing levels of miR +genetics_GWAS 34060972 hsa-mir-146a Arthritis, Rheumatoid CONCLUSIONS: In summary, this study supports that genetic variant in miR-146a gene is associated with RA risk.KEY MESSAGESThe association between SNPs in miR-146a gene and susceptibility of RA was unclear.We investigated the genetic association using GWASs data and a replication study.The SNP rs2431697 in miR-146a gene is associated with RA risk. +tissue_expression_ns 34060486 hsa-mir-181b-1 Virus Diseases miR-181ab1 deficiency in peripheral murine T cells causes delayed viral clearance after infection, resembling human immune aging. +tissue_expression_ns 34060486 hsa-mir-181a-1 Virus Diseases miR-181ab1 deficiency in peripheral murine T cells causes delayed viral clearance after infection, resembling human immune aging. +lncRNA target 34060486 hsa-mir-181a Virus Diseases In conclusion, SIRT1 inhibition may be beneficial to treat systemic viral infection in older individuals by targeting antigen-specific T cells that develop replication stress due to miR-181a deficiency. +lncRNA target 34060415 hsa-mir-520g Osteosarcoma Moreover, the silence of circ_0102049 could markedly promote the proliferation, invasion, migration and cell-cycle promotion while inhibiting the apoptosis of OS cell line MG63 cells in vitro through regulating miR-520g-3p/PLK2 axis. +genetics_knock down_suppress 34060267 hsa-mir-140 Myocardial Reperfusion Injury All in all, NEAT1 knockdown contributed to Sev-mediated myocardial I/R injury alleviation via the miR-140/RhoA axis. +lncRNA target 34059758 hsa-mir-182 Spinal Cord Injuries Taken together, these data indicate that miR-182 improved SCI-induced secondary injury through inhibiting apoptosis and the inflammatory response by blocking the IKKbeta/NF-kappaB pathway. +circulation_biomarker_diagnosis_down 34059576 hsa-mir-502 Osteoporotic Fractures 3p were down-regulated in serum of patients with OPF, both of which could be used as potential biomarkers for the diagnosis and disease evaluation of OPF. +other 34058990 hsa-mir-29b Osteoarthritis The circHYBID-hsa-miR-29b-3p-TGF-beta1 axis may play a powerful regulatory role in HA metabolism and OA progression. +other 34058789 hsa-mir-96 Adenocarcinoma In conclusion, this study sheds the light on M./P53/miR215/CD44 with an emphasis on M./miR96//foxO1 signaling cascades, as a novel pathway of melatonin signaling in adenocarcinoma to diminish cancer cell growth, survival and metastasis. +other 34058789 hsa-mir-215 Adenocarcinoma In conclusion, this study sheds the light on M./P53/miR215/CD44 with an emphasis on M./miR96//foxO1 signaling cascades, as a novel pathway of melatonin signaling in adenocarcinoma to diminish cancer cell growth, survival and metastasis. +transcription factor target 34058620 hsa-mir-1271 Myocardial Infarction, Acute miR5p decreased cardiomyocyte apoptosis induced by hypoxia and alleviated cardiac injury in AMI via down-regulating SOX6 expression. +transcription factor target 34058620 hsa-mir-1271 Heart Injuries miR5p decreased cardiomyocyte apoptosis induced by hypoxia and alleviated cardiac injury in AMI via down-regulating SOX6 expression. +other 34058504 hsa-mir-129 Prostatic Hyperplasia The findings led to the conclusion that the determination of miRNA-129 and VEGF can significantly contribute to the diagnosis of prostate disorders in dogs. +lncRNA target 34058384 hsa-mir-613 Carcinoma, Renal Cell lncHILAR promotes RCC cell invasion and metastasis via ceRNA for the miR-613/206/1 +lncRNA target 34058384 hsa-mir-206 Carcinoma, Renal Cell lncHILAR promotes RCC cell invasion and metastasis via ceRNA for the miR-613/206/1 +lncRNA target 34058384 hsa-mir-1-1 Carcinoma, Renal Cell lncHILAR promotes RCC cell invasion and metastasis via ceRNA for the miR-613/206/1 +circulation_biomarker_diagnosis_ns 34058227 hsa-mir-451 Ischemic Stroke By screening biomarkers in the peripheral blood of ischemic stroke patients, miR-451 was identified as a differentially expressed miRNA along the disease course of ischemic stroke. +circulation_biomarker_prognosis_up 34058065 hsa-mir-363 Breast Neoplasms Our study revealed, for the first time, plasma exosomal miR +genetics_GWAS 34057989 hsa-mir-29 Chordoma Somatic copy number gains of miR-29 loci in chordoma highlighted a mechanism of inactivation of TGFB3 signaling in tumor formation. +circRNA target 34057019 hsa-mir-936 Glioma Additionally, miR-936 inhibited the glioma development via targeting ERBB4. +genetics_overexpression_promote 34057012 hsa-mir-2053 Esophageal Squamous Cell Carcinoma After cell transfection, the effects of miR-2053 overexpression on proliferation, apoptosis, migration and invasion of esophageal cancer cells were determined. +genetics_overexpression_promote 34056735 hsa-mir-34a Urinary Bladder Neoplasms MiR-34a overexpression blocked bladder cancer cell migration and invasion, and induced cell apoptosis and cycle arrest, while these effects were abolished by CCND3 overexpression. +target gene 34056322 hsa-mir-7 Ovarian Neoplasms Liposomal Delivery of MicroRNA-7 Targeting EGFR to Inhibit the Growth, Invasion, and Migration of Ovarian Cancer. +lncRNA target 34056113 hsa-mir-326 Pancreatic Carcinoma CONCLUSION: circ_0066147 regulated PC malignant progression in part depending on the miR-326/E2F2 axis, illuminating circ_0066147 was a potential prognostic marker and therapeutic target for PC management. +lncRNA target 34056112 hsa-mir-136 Melanoma 5p suppressed melanoma progression by targeting RAB9A. +genetics_overexpression_promote 34056002 hsa-mir-603 Carcinoma, Hepatocellular FABP1 overexpression reduced ROS in HCC cells, while miR-603 can reverse these effects. +genetics_overexpression_promote 34055989 hsa-mir-126 Carcinoma, Non-Small-Cell Lung We also found that overexpression of ADAM9 could reverse the effects of miR +lncRNA target 34055978 hsa-mir-377 Colonic Neoplasms Additionally, after downregulating NEAT1 in CCCs, transfection of NEAT1 siRNA packed with CNPs brought a great inhibition on cell proliferation and a promotion on apoptosis, and inhibiting miR +epigenetics 34055974 hsa-mir-142 Carcinoma, Hepatocellular Finally, we found that miR-142 may be the important regulator for m(6)A RNA methylation in HCC. +genetics_overexpression_promote 34055896 hsa-mir-1251 Pancreatic Carcinoma The oncogenic effects of circ_0001666 on EMT and PC cell invasion were rescued by miR-1251 overexpression. CONCLUSIONS: These results suggested that circ_0001666 acts as an oncogenic circRNA to promote EMT and invasion of PC cells through sponging miR-1251, and indicated that circ_0001666 could be explored as a potential therapeutic target for PC. +other 34055841 hsa-mir-448 Carcinoma, Hepatocellular Conclusion: The newly identified PITPNA-AS/miR-448/ROCK1 axis promoted the oncogenicity of HCC cells. +genetics_overexpression_promote 34055778 hsa-mir-1290 Myocardial Infarction Furthermore, in vivo animal studies showed that exosomes from EPCs with miR-1246 or miR-1290 overexpression attenuated the MI-induced cardiac injury in the rats and caused an increase in ELF5, SP1, and CD31 expression, respectively, but suppressed alpha-SMA expression in the cardiac tissues. +exosome 34055778 hsa-mir-1246 Myocardial Infarction In conclusion, our study revealed that miR-1246 and miR-1290 in EPC-derived exosomes enhanced in vitro and in vivo angiogenesis in MI, and these improvements may be associated with amelioration of cardiac injury and cardiac fibrosis after MI. +other 34055770 hsa-mir-193 Placenta Diseases Urothelial Cancer Associated 1 (UCA1) and miR-193 Are Two Non-coding RNAs Involved in Trophoblast Fusion and Placental Diseases. +exosome 34055767 hsa-mir-9 Nerve Degeneration Thus, our data indicate that NSC-derived exosomes facilitate the differentiation of NSCs via transferring miR-9, which sheds light on the development of cell-free therapeutic strategies for treating neurodegeneration. +other 34055638 hsa-mir-105 Breast Neoplasms Conclusion In the present research, we identified 3 RNAs (hsa-miR5p, BCAR1 and PANX2) might associated with prognosis and metastasis of breast cancer, which might be provide a new perspective for metastasis of breast cancer and contributed to the treatment of breast cancer. +other 34055628 hsa-mir-493 Urinary Bladder Neoplasms Long Noncoding RNA SNHG1 Activates Autophagy and Promotes Cell Invasion in Bladder Cancer as a sponge of miR-493-5p +genetics_GWAS 34055578 hsa-mir-342 Chromosome Aberrations The relevance of miRNA- (miR-) 342 to endometriosis has been highlighted, while its function in regulating the malignant-like phenotype of endometrial stromal cells which demonstrate epigenetic abnormalities that alter expression of transcription factors, remains unclear. +other 34055578 hsa-mir-342 Cervical Intraepithelial Neoplasia We first characterized the levels of miR-342 and ANXA2 in 31 cases of normal endometrium from patients with grade II-III cervical intraepithelial neoplasia or patients with hysterectomy versus ectopic endometrial tissues of 42 patients with endometriosis. +genetics_GWAS 34055578 hsa-mir-342 Endometriosis The relevance of miRNA- (miR-) 342 to endometriosis has been highlighted, while its function in regulating the malignant-like phenotype of endometrial stromal cells which demonstrate epigenetic abnormalities that alter expression of transcription factors, remains unclear. +circulation_biomarker_diagnosis_up 34055487 hsa-mir-93 Prostatic Neoplasms 5p) in peripheral serum which could act as a non-invasive biomarker helping diagnosing PC. +other 34055120 hsa-mir-155 Low Back Pain In subjects with moderate to severe LBP, the expression levels of miR-146a and miR-558 were significantly reduced and those of miR-155 and miR-124a were significantly increased compared to subjects with minimal LBP scores. +other 34055120 hsa-mir-124a Low Back Pain In subjects with moderate to severe LBP, the expression levels of miR-146a and miR-558 were significantly reduced and those of miR-155 and miR-124a were significantly increased compared to subjects with minimal LBP scores. +other 34055120 hsa-mir-558 Low Back Pain In subjects with moderate to severe LBP, the expression levels of miR-146a and miR-558 were significantly reduced and those of miR-155 and miR-124a were significantly increased compared to subjects with minimal LBP scores. +other 34055120 hsa-mir-146a Low Back Pain In subjects with moderate to severe LBP, the expression levels of miR-146a and miR-558 were significantly reduced and those of miR-155 and miR-124a were significantly increased compared to subjects with minimal LBP scores. +lncRNA target 34055094 hsa-mir-195 Carcinoma, Non-Small-Cell Lung 5p/ITGA2 signalling pathway might be an attractive target for future therapeutic options in NSCLC. +genetics_knock down_promote 34055079 hsa-mir-3677 Carcinoma, Hepatocellular 5p was indicated to significantly promote the proliferation, migration and invasion of HCC cells, whereas knockdown of miR +target gene 34055067 hsa-mir-1297 Prostatic Neoplasms Silencing miRNA-1297 suppresses the invasion and migration of prostate cancer cells via targeting modulation of PTEN and blocking of the AKT/ERK pathway. +target gene 34055060 hsa-mir-489 Psoriasis miR-489-3p inhibits TLR4/NF-κB signaling to prevent inflammation in psoriasis. +other 34055058 hsa-mir-184 Thyroid Neoplasms Thymosin β10 mediates the effects of microRNA-184 in the proliferation and epithelial-mesenchymal transition of BCPAP cells. +lncRNA target 34054958 hsa-mir-942 Stomach Neoplasms More importantly, breast cancer metastasis suppressor 1 (BRMS1) inhibited GC progression by upregulating lncRNA HCG11 and downregulating miR +other 34054957 hsa-mir-25 Colorectal Neoplasms CONCLUSION: Our results indicated that MSC-AS1 facilitated CRC progression by sponging miR-325 to upregulate TRIM14 expression. +other 34054947 hsa-mir-122 Diabetes Mellitus At present, there are few reports concerning the relationship between miR-122 and diabetes. The present study aimed to investigate the role and modulatory mechanisms involving miR-122 in diabetes. +other 34054723 hsa-mir-103a Infertility Finally, we used the candidate miRNAs, miR-103a-3p and miR-10a-5p, to further investigate the relationship between their expression in FF and the outcomes of infertile patients undergoing IVF-ET treatment. Moreover, in another cohort of 106 infertile women undergoing IVF-ET treatment, miR-103a-3p or miR-10a-5p expression predicted the developmental status of the corresponding oocytes in which high expression of miR-103a-3p or miR-10a-5p resulted in a poor quality of embryo on days 3 and 5 during the IVF-ET treatment. +other 34054723 hsa-mir-10a Infertility Finally, we used the candidate miRNAs, miR-103a-3p and miR-10a-5p, to further investigate the relationship between their expression in FF and the outcomes of infertile patients undergoing IVF-ET treatment. Moreover, in another cohort of 106 infertile women undergoing IVF-ET treatment, miR-103a-3p or miR-10a-5p expression predicted the developmental status of the corresponding oocytes in which high expression of miR-103a-3p or miR-10a-5p resulted in a poor quality of embryo on days 3 and 5 during the IVF-ET treatment. +target gene 34054537 hsa-mir-578 Carcinoma, Non-Small-Cell Lung CircRNA circ_0006677 Inhibits the Progression and Glycolysis in Non-Small-Cell Lung Cancer by Sponging miR-578 and Regulating SOCS2 Expression. +lncRNA target 34054430 hsa-mir-93 Spinal Cord Injuries These findings suggest that the GAS5/miR-93/PTEN axis may be a promising therapeutic target for SCI. +lncRNA target 34054299 hsa-mir-17 Chordoma CONCLUSION: Our results revealed the potential oncogenic effect of the miR-17/93 on chordoma progression, and suggested that the miR-17/93-p21 axis served as a promising therapeutic target in chordoma. +lncRNA target 34053876 hsa-mir-628 Carcinoma, Hepatocellular CONCLUSIONS: ILF3-AS1 promoted hepatocellular carcinoma progression via the Notch pathway and miR +genetics_knock down_promote 34053467 hsa-mir-122 Uterine Cervical Neoplasms 5p in self-renewal and differentiation ability of CC stem cells were determined using ectopic expression, knockdown/depletion and reporter assay experiments. +circulation_biomarker_diagnosis_up 34053079 hsa-mir-1246 Mycosis Fungoides Specifically, exomiR-1246 (and not exomiR-155) was higher in plasma of plaque/tumour MF than in healthy controls. +circulation_biomarker_diagnosis_up 34053079 hsa-mir-155 Mycosis Fungoides Specifically, exomiR-1246 (and not exomiR-155) was higher in plasma of plaque/tumour MF than in healthy controls. +circulation_biomarker_diagnosis_up 34053079 hsa-mir-155 Plaque, Atherosclerotic Plasma levels of cfmiR-1246 were significantly highest in combined plaque/tumour MF, followed by patch MF, and were lowest in controls (plaque/tumour > patch > healthy), while cfmiR-155 was upregulated only in plaque/tumour MF vs. Specifically, exomiR-1246 (and not exomiR-155) was higher in plasma of plaque/tumour MF than in healthy controls. +circulation_biomarker_diagnosis_up 34053079 hsa-mir-1246 Plaque, Atherosclerotic Plasma levels of cfmiR-1246 were significantly highest in combined plaque/tumour MF, followed by patch MF, and were lowest in controls (plaque/tumour > patch > healthy), while cfmiR-155 was upregulated only in plaque/tumour MF vs. Specifically, exomiR-1246 (and not exomiR-155) was higher in plasma of plaque/tumour MF than in healthy controls. +exosome 34052997 hsa-mir-146a Thrombocytopenia In conclusion, these findings demonstrate that BMSC-derived exosomal miR-146a-5p regulates Th17/Treg imbalance in ITP by repressing IRAK1 expression. Thus, this work suggests that BMSCs-exosomal miR-146a-5p may be a potential therapeutic target for ITP. +genetics_overexpression_promote 34052838 hsa-mir-194 Brain Ischemia Overexpression of circ_0000296 by miR +exosome 34052737 hsa-mir-361 Osteoarthritis Overall, hBMSC-derived exosomal miR +other 34052462 hsa-mir-149 Osteoarthritis METHODS: An initial database search led to the identification of miR5p, which was downregulated in clinical OA samples and contributed to chronic inflammation, by increasing TNF-alpha/IL-6 signaling within the synovium, and OA progression. +lncRNA target 34052320 hsa-mir-941 Homozygous Familial Hypercholesterolemia Validation through quantitative PCR of genes and miRNAs from 52 HoFH patients and 20 healthy controls revealed that the expression levels of hsa-miR +lncRNA target 34052320 hsa-mir-941 Atherosclerosis Validation through quantitative PCR of genes and miRNAs from 52 HoFH patients and 20 healthy controls revealed that the expression levels of hsa-miR +lncRNA target 34052320 hsa-mir-486 Atherosclerosis Validation through quantitative PCR of genes and miRNAs from 52 HoFH patients and 20 healthy controls revealed that the expression levels of hsa-miR +lncRNA target 34052320 hsa-mir-486 Homozygous Familial Hypercholesterolemia Validation through quantitative PCR of genes and miRNAs from 52 HoFH patients and 20 healthy controls revealed that the expression levels of hsa-miR +lncRNA target 34052307 hsa-mir-132 Lipid Metabolism Disorders Taken together, our results revealed that lncRNA PCA3 promotes antimony-induced lipid metabolic disorder in prostate cancer by targeting MIR3 P/SREBP1 signaling. +lncRNA target 34052307 hsa-mir-132 Prostatic Neoplasms Taken together, our results revealed that lncRNA PCA3 promotes antimony-induced lipid metabolic disorder in prostate cancer by targeting MIR3 P/SREBP1 signaling. +transcription factor target 34052187 hsa-mir-96 non-alcoholic steatohepatitis Being a critical player in NASH development, caspase-2 targeting by miRNA5p could be a promising therapeutic modality to treat NASH. +lncRNA target 34051811 hsa-mir-520c Cartilage Diseases CONCLUSION: Our data showed that miR-520c-3p might regulate the GAS2 to inhibit the progression of OA. +other 34051810 hsa-mir-139 Ovarian Neoplasms LncRNA WDFY3-AS2 promotes cisplatin resistance and the cancer stem cell in ovarian cancer by regulating hsa-miR-139-5p/SDC4 axis. +lncRNA target 34051661 hsa-mir-128 Prostatic Neoplasms Taken together, our data indicate that lncRNA OIP5-AS1 promotes PCa progression and ferroptosis resistance through miR +transcription factor target 34051305 hsa-mir-16 Diabetes Mellitus These findings suggest that EGCG and quercetin exert synergistic anti-diabetes effect, possibly via decreasing the expression of miR5p that targets directly BCL-2. +genetics_knock down_promote 34051279 hsa-mir-24 Spinal Cord Injuries 5p alleviates the loss of animal locomotion and concurrently mediates several degenerative processes relevant to the pathogenesis of SCI by Sirt1, which may provide clues for SCI treatment. +transcription factor target 34051007 hsa-mir-4443 Thyroid Cancer, Papillary We found that ectopic expression of miR-4443 inhibited PTC cell migration, invasion, ATP production, and aerobic glycolysis, while inhibition of miR-4443 had the opposite effect. +genetics_overexpression_promote 34050852 hsa-mir-21 Stomach Neoplasms 5p overexpression attenuated Lidocaine-induced anti-proliferative and anti-metastatic effects on GC cells. +genetics_knock down_promote 34050851 hsa-mir-619 Carcinoma, Non-Small-Cell Lung Collectively, HOXA11-AS knockdown inhibited the progression of NSCLC by regulating miR +lncRNA target 34050453 hsa-mir-199a Neuroblastoma Overall, down-regulation of ID2-AS1 alleviated the neuronal injury in PD through regulating miR-199a-5p/IFNAR1/JAK2/STAT1 axis. +genetics_overexpression_promote 34050452 hsa-mir-653 Breast Neoplasms HMGA2 overexpression abrogated the effect of miR +other 34050318 hsa-mir-143 Colorectal Neoplasms Consistently, an inverse correlation between miR-143/miR-145 and CBFbeta expression levels is present in CRC patients. +other 34050318 hsa-mir-145 Colorectal Neoplasms Consistently, an inverse correlation between miR-143/miR-145 and CBFbeta expression levels is present in CRC patients. +circulation_biomarker_diagnosis_down 34050266 hsa-mir-27a Colorectal Neoplasms Importantly, the expression levels of serum Linc00284 and miR-27a may serve as clinical biomarkers for CRC diagnosis. +genetics_overexpression_suppress 34050139 hsa-mir-518d Carcinoma, Hepatocellular In vitro and in vivo studies were performed in human hepatoma BCLC3 and Huh7 cells to analyze the effect of miR-518d-5p inhibition/overexpression during the response to sorafenib. +genetics_overexpression_promote 34050115 hsa-mir-148a Glioblastoma Cell invasion and migration analysis showed that overexpression of RP11-390F4.3 and ROCK1 resulted in increased, and overexpression of miR-148a resulted in deceased invasion and migration rates of glioblastoma cells. +genetics_knock down_promote 34050113 hsa-mir-338 Neuroblastoma 3p recovered the inhibitory effect of DANCR knockdown on neuroblastoma progression. +circulation_biomarker_prognosis_ns 34050091 hsa-mir-137 Intracranial Arteriosclerosis In conclusions, our findings indicate that serum miR-137 levels are decreased in patients with cerebral AS and may be a new biomarker for diagnosing cerebral AS and predicting cerebrovascular events. +circulation_biomarker_prognosis_ns 34050091 hsa-mir-137 Cerebrovascular Disorders In conclusions, our findings indicate that serum miR-137 levels are decreased in patients with cerebral AS and may be a new biomarker for diagnosing cerebral AS and predicting cerebrovascular events. +transcription factor target 34048990 hsa-mir-340 Urinary Bladder Neoplasms Here, we proved that propofol regulated miR-340/CDK2 axis to suppress bladder cancer progression in vitro. CONCLUSION: In total, our results proved that targeting miR340/CDK2 axis was novel to enhance the anti-tumor effects of propofol in bladder cancer in vitro, and our study provided alternative therapeutic strategies for clinical treatment of bladder cancer. +transcription factor target 34048989 hsa-mir-155 Hypoxia DEX, via down-regulating the expression of miR-155, could activate the ERK1/2 pathway, thereby mitigating the apoptosis and oxidative stress injury and increasing the MMP, thereby protecting hippocampal cells from OGD/R injury. +other 34048924 hsa-mir-23a Uterine Cervical Neoplasms Furthermore, some XIST-associated axes, namely XIST | miR-23a-3p | LGR4 and XIST | miR-30b-5p or miR-30c-5p or miR-30e-5p I ADAM9, had a significant impact on the overall survival of HPV16- and HPV18-CESC patients, respectively. +genetics_knock down_promote 34048784 hsa-mir-141 Keloid LINC01116 knockdown or miR-3141 overexpression suppressed keloid fibroblast proliferation, migration, and promoted cell apoptosis. +transcription factor target 34048646 hsa-mir-155 Inflammation Therefore, sequential detection of inflammation-related miR-155 (by external modified hairpin DNAs) and the cancer target of monocarboxylate transporter 1 (MCT1) (by internal loaded pH-sensitive carbon dots and MCT1 inhibitor-AZD3965) are achieved. +lncRNA target 34048366 hsa-mir-340 Osteosarcoma In conclusion, our study demonstrated that RUSC1-AS1 promoted osteosarcoma development both in vitro and in vivo through sponging to miR5p and activating the PI3K/AKT signaling pathway. +genetics_overexpression_promote 34048322 hsa-mir-451 Glioma We demonstrated that overexpression of miR-451 suppressed glioma cell proliferation, invasion, migration and EMT by MTT and colony formation assays, Transwell assays, wound healing assays and animal experiments. +genetics_overexpression_promote 34048311 hsa-let-7i ankylosing spondylitis 1 Ankylosing spondylitis (AS) is a chronic autoimmune disease in which let-7i has been studied to involved. Low expression of let-7i-3p could enhance osteoblast differentiation in AS by up-regulating PDK1.Abbreviations: AS: Ankylosing spondylitis; PDK1: pyruvate dehydrogenase kinase 1; TNF-alpha: tumor necrosis factor-alpha MMP: matrix metalloproteinase; OPG: osteoprotegerin; RANKL: receptor activator of nuclear factor-kappaB ligand; miRNAs: MicroRNAs; BMD: bone mineral density; PFA: paraformaldehyde; NC: negative control; OE: overexpression; HE: Hematoxylin-eosin; PBS: phosphate-buffered saline; EDTA: ethylene diamine tetraacetic acid; DMEM: Dulbecco's Modified Eagle Medium; RT-qPCR: Reverse transcription quantitative polymerase chain reaction; GAPDH: glyceraldehyde phosphate dehydrogenase; UTR: untranslated region; WT: wild type; MUT: mutant type. +circulation_biomarker_diagnosis_up 34048187 hsa-mir-92a Precursor Cell Lymphoblastic Leukemia-Lymphoma RESULTS: plasma miRNA 92a and miRNA 638 expressions were elevated in ALL cases at the time of diagnosis (2.51 and 2.19 folds), and relapsed (2.1 and 1.61 folds) than that of patients with remitted ALL. +circulation_biomarker_diagnosis_up 34048187 hsa-mir-638 Precursor Cell Lymphoblastic Leukemia-Lymphoma RESULTS: plasma miRNA 92a and miRNA 638 expressions were elevated in ALL cases at the time of diagnosis (2.51 and 2.19 folds), and relapsed (2.1 and 1.61 folds) than that of patients with remitted ALL. +other 34048164 hsa-mir-145 Breast Neoplasms 5p could be potential biomarkers to distinguish breast cancer patients from healthy controls. +other 34048164 hsa-mir-22 Breast Neoplasms 5p could be potential biomarkers to distinguish breast cancer patients from healthy controls. +other 34048164 hsa-mir-27b Breast Neoplasms 5p could be potential biomarkers to distinguish breast cancer patients from healthy controls. +other 34047878 hsa-mir-637 Glioblastoma Presently, we observed the increased expression of ZEB2 and the decreased expression of miR-637 in GBM. The collective findings suggest that ZEB2 and WNT/beta-catenin cascades merge at miR-637, and the ectopic expression of miR-637 disturbs ZEB2/WNT/beta-catenin-mediated GBM growth. +other 34047479 hsa-mir-199a Carcinoma, Hepatocellular LINC01133 sponged miR-199a-5p, resulting in enhanced expression of SNAI1, which induced epithelial-to-mesenchymal transition (EMT) in HCC cells. CONCLUSIONS: LINC01133 promotes HCC progression by sponging miR-199a-5p and interacting with ANXA2. +circRNA target 34046939 hsa-mir-665 Uterine Cervical Neoplasms Mechanistically, circMYBL2 could inhibit the PTX sensitivity and promote cell malignant behaviors in PTX-sensitive and PTX-resistant CC cells via upregulating EGFR mediated by miR-665. CircMYBL2 played a positive role in the PTX resistance and malignant activities of PTX-sensitive and PTX-resistant CC cells by regulating the miR-665/EGFR network, providing a novel therapeutic strategy for the treatment of CC patients resistant to PTX. +target gene 34046406 hsa-mir-182 Thyroid Neoplasms Long Non-coding RNA RUNDC3A-AS1 Promotes Lung Metastasis of Thyroid Cancer via Targeting the miR-182-5p/ADAM9. +transcription factor target 34046357 hsa-mir-200 Colorectal Neoplasms Our results suggest the involvement of partial EMT at invasive tumor front, and partial MET in metastases in CRC, based on miR-200 family and its target genes expression. +other 34046349 hsa-mir-21 Adenocarcinoma of Lung Here, we tested the potential mechanism of miRNA-21 in cisplatin-resistant non-small cell lung cancer A549/DDP (human lung adenocarcinoma drug-resistant cell line) cells. +other 34046349 hsa-mir-21 Carcinoma, Non-Small-Cell Lung Here, we tested the potential mechanism of miRNA-21 in cisplatin-resistant non-small cell lung cancer A549/DDP (human lung adenocarcinoma drug-resistant cell line) cells. Hence, reduction of the expression of miRNA-21 in combination with cisplatin chemotherapy may effectively improve the therapeutic effect on patients with non-small cell lung cancer, and this may provide a theoretical basis for the treatment of this disease. +other 34046191 hsa-mir-1915 Chorioamnionitis 5p serve as promising biomarkers for the diagnosis of severe chorioamnionitis. +other 34046191 hsa-mir-4535 Chorioamnionitis 5p serve as promising biomarkers for the diagnosis of severe chorioamnionitis. +lncRNA target 34045897 hsa-mir-520a Nasopharyngeal Carcinoma CONCLUSION: These results suggest that SNHG16 acts as an oncogene in the progression of NPC via modulating the miR-520a-3p/MAPK1 axis. +exosome 34045869 hsa-mir-31 Colonic Neoplasms CONCLUSION: Circ-PI4KA attenuated SEV-treated colon cancer cell malignancy by upregulating LASP1 through binding to miR +other 34045679 hsa-mir-150 Sepsis Taken together, our data show that XIST/miR5p/c-Fos axis affected septic myocardial injury, which may indicate a novel therapeutic strategy for sepsis-induced myocardial injury. +other 34045679 hsa-mir-150 Cardiomyopathies Taken together, our data show that XIST/miR5p/c-Fos axis affected septic myocardial injury, which may indicate a novel therapeutic strategy for sepsis-induced myocardial injury. +lncRNA target 34045663 hsa-mir-28 Breast Neoplasms 3p is a potential therapeutic target for the treatment of breast cancer patients with metastasis, and also a model for the miRNA-fatty acid beta-oxidation-stemness axis, which may assist inunderstanding the cancer stem cell signaling functions of miRNA. +genetics_overexpression_suppress 34045601 hsa-mir-9 Prostatic Neoplasms Taken together, our results suggest that inhibiting the expression of the oncomiR miR5p and overexpressing NUMB may represent novel therapeutic strategies to target PCSCs and PCa metastasis. +lncRNA target 34045549 hsa-mir-26b Pre-Eclampsia The finding of anti-inflammatory property by vitamin D through promotion of VDR/miR-26b-5p expression provides significant evidence that downregulation of vitamin D/VDR signaling could contribute to increased inflammatory response in preeclampsia. +other 34045467 hsa-mir-200c Breast Neoplasms MicroRNA-200c restoration reveals a cytokine profile to enhance M1 macrophage polarization in breast cancer. +lncRNA target 34045139 hsa-mir-204 Osteoarthritis 5p in regulating inflammatory responses of human osteoarthritic synovial fibroblasts (SFs). +lncRNA target 34044859 hsa-mir-449a Lung Neoplasms CONCLUSION: It is eventually concluded that miR-449a delays lung cancer development through suppressing KDM3A/HIF-1alpha axis. +other 34044826 hsa-mir-6734 Glioma 3p to facilitate glioma development, proposing LINC01158 as a new player in glioma. +circulation_biomarker_diagnosis_up 34044822 hsa-mir-1250 Lymphoma, Non-Hodgkin METHODS: AATK/miR-1250 methylation was studied in healthy controls, including ten normal peripheral blood buffy coats and eleven normal tonsils, ten lymphoma cell lines, and 120 primary lymphoma samples by methylation-specific PCR (MSP). +transcription factor target 34044650 hsa-mir-564 Lupus Erythematosus, Systemic RESULTS: Bioinformatics analysis showed that miR-564 was up-regulated in SLE patients, and TP53 was the core target gene of miR-564. +genetics_overexpression_promote 34044640 hsa-mir-572 Prostatic Neoplasms Overexpression of miR-572 decreased sensitivity of PCa cells to docetaxel treatment by reducing docetaxel-induced apoptosis. +transcription factor target 34044364 hsa-mir-3074 Abortion, Spontaneous 5p expression in ESCs might cause early pregnancy failure by disturbing decidualization of ESCs via the miR +other 34043986 hsa-mir-133a Cardiomyopathies Therefore, interfering with circHelz/miR-133a-3p/NLRP3 axis might be a promising therapeutic approach for ischemic cardiac diseases. +other 34043986 hsa-mir-133a Myocardial Infarction Therefore, interfering with circHelz/miR-133a-3p/NLRP3 axis might be a promising therapeutic approach for ischemic cardiac diseases. +lncRNA target 34043929 hsa-mir-21 Carcinoma, Non-Small-Cell Lung The respective targets of EV miR-21, miR-210, and miR-1290 could activate PI3K/AKT-related pathway.Conclusion: EV miRNAs had high diagnostic accuracy (AUC = 0.86) for NSCLC, especially metastatic NSCLC (AUC = 0.90), and early-stage NSCLC (AUC = 0.88). EV miR-21, miR-210, and miR-1290 might be associated with PI3K/AKT-related pathway and the valuable diagnostic biomarkers for NSCLC. +lncRNA target 34043929 hsa-mir-210 Carcinoma, Non-Small-Cell Lung The respective targets of EV miR-21, miR-210, and miR-1290 could activate PI3K/AKT-related pathway.Conclusion: EV miRNAs had high diagnostic accuracy (AUC = 0.86) for NSCLC, especially metastatic NSCLC (AUC = 0.90), and early-stage NSCLC (AUC = 0.88). EV miR-21, miR-210, and miR-1290 might be associated with PI3K/AKT-related pathway and the valuable diagnostic biomarkers for NSCLC. +lncRNA target 34043929 hsa-mir-1290 Carcinoma, Non-Small-Cell Lung The respective targets of EV miR-21, miR-210, and miR-1290 could activate PI3K/AKT-related pathway.Conclusion: EV miRNAs had high diagnostic accuracy (AUC = 0.86) for NSCLC, especially metastatic NSCLC (AUC = 0.90), and early-stage NSCLC (AUC = 0.88). EV miR-21, miR-210, and miR-1290 might be associated with PI3K/AKT-related pathway and the valuable diagnostic biomarkers for NSCLC. +genetics_knock down_suppress 34043680 hsa-mir-377 Osteoporosis Furthermore, the therapeutic effect of hsa_circ_0001275 knockdown on osteoporosis was notably reversed by miR-377 antagomir. +other 34043149 hsa-mir-130a Breast Neoplasms In addition, bioinformatic analyses indicated that LINC00963/hsa-mir-130a-3p/HSPA8 axis might have potential regulatory role in BC. +lncRNA target 34043125 hsa-mir-145 Prostatic Neoplasms Our results suggested that miR-145 suppressed the motility of prostate cancer cells via post-transcriptional downregulation of CDH2 expression, and miR +other 34042547 hsa-mir-382 Myocardial Infarction, Acute 5p reduced apoptosis of myocardial cells after AMI and the effect was achieved by increasing STC1 expression. +other 34042291 hsa-mir-206 Cardiac Complexes Using a full structural equitation modelling of the total study sample, we found that the higher the increase in MF was observed in patients, the higher the probability of a decrease in the expression of miR-206 and TRIM63 and the lower severity of cardiac comorbidities. +other 34042286 hsa-mir-128 Colitis 3p in IBD, experimental colitis animal model was generated by 2,4,6-Trinitrobenzenesulfonic acid solution (TNBS). +circulation_biomarker_diagnosis_up 34042273 hsa-mir-202 Alzheimer Disease In summary, we showed novel data that downregulation of serum miR-202 may be used as a potential biomarker for AD and may promote the development of AD by targeting APP. +genetics_overexpression_suppress 34042256 hsa-mir-192 Uterine Cervical Neoplasms Finally, we found that TRPM7 overexpression reversed the inhibitory effects of miR +genetics_overexpression_promote 34042220 hsa-mir-10396 Hypertrophy Our results showed that overexpression of miR-10396b-3p suppresses MS-induced LFH by inhibiting collagen I and III via the inhibition of IL-11. These data suggest that the MS-miR-10396b-3p-IL-11 axis plays a key role in the pathological progression of LFH. +genetics_knock down_promote 34041718 hsa-mir-188 Osteosarcoma This study revealed that HCG18 knockdown repressed the viability, invasion and migration of OS cells by targeting miR +transcription factor target 34041689 hsa-mir-9 Fahr's disease Bioinformatics analysis predicts almost 100 ion channels, membrane transporters and receptors, including genes linked to primary familial brain calcification (PFBC), as possible miR5p targets. +transcription factor target 34041689 hsa-mir-9 Progressive Familial Heart Block, Type Ib 5p targets. +genetics_knock down_promote 34041646 hsa-mir-30 Respiratory Distress Syndrome In short, circANKRD36 knockdown suppressed cell viability and migration of LPS-stimulated RAW264.7 cells in vitro via sponging miR-330, which may provide new ideas for the treatment of sepsis-induced ARDS. +genetics_knock down_promote 34041646 hsa-mir-30 Sepsis In short, circANKRD36 knockdown suppressed cell viability and migration of LPS-stimulated RAW264.7 cells in vitro via sponging miR-330, which may provide new ideas for the treatment of sepsis-induced ARDS. +lncRNA target 34041621 hsa-mir-26 Triple Negative Breast Neoplasms 3p as prognostic and therapeutic targets that can be exploited to predict or prevent BM. +lncRNA target 34041621 hsa-mir-101 Triple Negative Breast Neoplasms 3p as prognostic and therapeutic targets that can be exploited to predict or prevent BM. +other 34041583 hsa-mir-92a Pituitary Diseases MicroRNA (miR)-92a in the inflammatory endothelial dysfunction leads to atherosclerosis. +other 34041583 hsa-mir-92a Decompression Sickness RESULTS: MiR-92a increased after balloon injury and was present in HCAEC culture media. Chrysin was treated, and significantly attenuated the miR-92a levels after balloon injury, and similar results were obtained in HCAEC cultures in vitro. +exosome 34041043 hsa-mir-92a Acute Lung Injury In conclusion, AEC-derived exosomes activate AMs and induce pulmonary inflammation mediated by miR-92a-3p in ALI. miR-92a-3p in AEC exosomes might represent a novel diagnostic biomarker for ALI, which may lead to a new therapeutic approach. +exosome 34041043 hsa-mir-92a Sepsis In conclusion, AEC-derived exosomes activate AMs and induce pulmonary inflammation mediated by miR-92a-3p in ALI. miR-92a-3p in AEC exosomes might represent a novel diagnostic biomarker for ALI, which may lead to a new therapeutic approach. +transcription factor target 34040893 hsa-mir-199a Liver Cirrhosis Notably, downregulation of miR-199a-5p decreased TGF-beta1-induced expression of fibrosis markers. CONCLUSIONS: DZNep suppresses hepatic fibrosis through regulating miR-199a-5p/SOCS7 axis, suggesting that DZNep may represent a novel treatment for fibrosis. +genetics_overexpression_promote 34040437 hsa-mir-142 Carcinoma, Non-Small-Cell Lung 5p inhibition and NFAT5 overexpression offset the suppressive impact of circ_0001944 silencing on proliferation, migration, invasion, and glycolysis of NSCLC cells. +circulation_biomarker_diagnosis_ns 34040409 hsa-mir-122 Metabolic Associated Fatty Liver Disease OBJECTIVE: To evaluate the association of micro-RNA-122 and the degree of steatosis and fibrosis in obese patients with MAFLD. CONCLUSION: Serum micro-RNA-122 could be a useful predictor of assessing MAFLD severity regarding level of steatosis or fibrosis. +other 34040396 hsa-mir-21 Asthma RESULTS: The expression of miR5p was upregulated in macrophages of rats in vivo with OVA-induced asthma. +genetics_knock down_promote 34040392 hsa-mir-215 Thyroid Cancer, Papillary 5p was a direct target of circWDR27, and its inhibition reversed the suppressive effect of circWDR27 knockdown on PTC cell progression. +target gene 34040389 hsa-mir-29b Stomach Neoplasms MicroRNA-29b-3p Inhibits the Migration and Invasion of Gastric Cancer Cells by Regulating the Autophagy-Associated Protein MAZ. +target gene 34040388 hsa-mir-545 Neuroblastoma Long Noncoding RNA LINC01410 Suppresses Tumorigenesis and Enhances Radiosensitivity in Neuroblastoma Cells Through Regulating miR-545-3p/HK2 Axis. +other 34040387 hsa-mir-145 Cholangiocarcinoma 5p/MAL2 axis could enhance CHOL progression, which might be useful to improve the clinical outcomes of CHOL patients. +other 34040372 hsa-mir-21 Osteoporosis CONCLUSION: We have described for the first time a new concept of osteoporosis treatment based on nHAp/IO@miR-21/124 application. +other 34040139 hsa-mir-148a Adenocarcinoma of Lung Then, six prognostic RNAs (FKBP3, GPI, LOXL2, IL22RA1, GPR37, and has-miR-148a-3p) were viewed as the key members for constructing the prognostic prediction model in the ceRNA network, and three kinds of TIICs (Monocytes, Macrophages M1, activated mast cells) were identified to be significantly related with the prognosis in lung adenocarcinoma. +other 34040057 hsa-mir-23b Multiple Myeloma Transcription factor regulatory networks were determined for five seed DEGs with >/= 4 biomarker applications (CDKN1A, CDKN2A, MMP9, IGF1, MKI67) and three topmost up/ down regulated DEMs (miR-23b, 195, let7b/ miR-20a, 155, 92a). +other 34040057 hsa-let-7b Multiple Myeloma Transcription factor regulatory networks were determined for five seed DEGs with >/= 4 biomarker applications (CDKN1A, CDKN2A, MMP9, IGF1, MKI67) and three topmost up/ down regulated DEMs (miR-23b, 195, let7b/ miR-20a, 155, 92a). +other 34040057 hsa-mir-20a Multiple Myeloma Transcription factor regulatory networks were determined for five seed DEGs with >/= 4 biomarker applications (CDKN1A, CDKN2A, MMP9, IGF1, MKI67) and three topmost up/ down regulated DEMs (miR-23b, 195, let7b/ miR-20a, 155, 92a). +other 34039992 hsa-mir-34a Colorectal Neoplasms To generate training data, colorectal cancer HCT116 cells were subjected to miR-34a treatment and then classified using a conventional Annexin V/propidium iodide (PI)-staining assay. +genetics_overexpression_promote 34039939 hsa-mir-16 Melanoma Rescued experiments confirmed that SOX4 overexpression abolished the inhibition effect of miR-16 mimics on growth, metastasis and EMT process of melanoma. +genetics_knock down_promote 34039781 hsa-mir-34a Precursor T-Cell Lymphoblastic Leukemia-Lymphoma In conclusion, our results demonstrated that knockdown of miR-34a-5p in extracellular vesicles derived from T-ALL cells promoted osteogenic differentiation of BMSCs by regulating WNT1. +transcription factor target 34039371 hsa-mir-20a Encephalomyelitis, Autoimmune, Experimental miR-20a is dysregulated in patients with CNS inflammatory demyelinating diseases; however, the function of miR-20a remains unclear. miR-20a antagomirs alleviate EAE, suggesting a new therapy for EAE and CNS inflammatory demyelinating diseases. +lncRNA target 34039026 hsa-mir-181b Leukemia, Lymphocytic, Chronic, B-Cell Conclusion:CARD11 is a novel target of miR-181b that is upregulated, which could be a poor prognostic indicator for CLL patients. +other 34038763 hsa-mir-34b Atherosclerosis Herein we sought to assess whether the miR-34 family members miR-34a, miR-34b and miR-34c are involved in human arterial disease. +other 34038763 hsa-mir-34c Atherosclerosis Herein we sought to assess whether the miR-34 family members miR-34a, miR-34b and miR-34c are involved in human arterial disease. +other 34038612 hsa-mir-96 Carcinoma, Hepatocellular Identification of microRNA-96-5p as a postoperative, prognostic microRNA predictor in nonviral hepatocellular carcinoma. +lncRNA target 34038520 hsa-mir-206 Colorectal Neoplasms Mechanistic studies (Bioinformatics binding site analyses, the Luciferase reporter, Ago2 immunoprecipitation, the RNA pull-down, immunofluorescence colocalization, rescued assays and western blotting) implicated that RP11-51O6.1 could regulate YAP1 expression by competitively sponging miR-206 and blocking its activity in promoting CRC progression. Conclusively, our findings identify a novel RP11-51O6.1/miR-206/YAP1 regulatory axis that participates in CRC progression and development, suggesting RP11-51O6.1 is an exploitable biomarker and appealing therapeutic target in treating CRC. +genetics_overexpression_promote 34038200 hsa-mir-99a Squamous Cell Carcinoma of Head and Neck Functional assays revealed that miR-99a-5p overexpression significantly inhibited the proliferation, migration, and invasion abilities of CAL-27 and TCA-8113 OSCC cells. +circulation_biomarker_diagnosis_up 34038062 hsa-mir-874 Pneumonia 3p was reduced in serum samples of pediatric patients with pneumonia, and LPS treatment dose-dependently decreased miR +other 34038061 hsa-mir-496 Adenocarcinoma of Lung Mir-496 may be an independent prognostic factor in lung adenocarcinoma. +lncRNA target 34037971 hsa-mir-124 Myocardial Infarction Silencing miR-124 could inhibit the inflammation and apoptosis of myocardial cells, thereby relieving the MI injury via upregulation of STAT3. +lncRNA target 34037903 hsa-mir-362 Reperfusion Injury, Cerebral Ischemia In conclusion, depletion of XIST attenuated I/R-induced neurological impairment and inflammatory response via the miR-362/ROCK2 axis. +genetics_overexpression_suppress 34037470 hsa-mir-494 Acute Lung Injury Overexpression of miR +lncRNA target 34037099 hsa-mir-182 Prostatic Neoplasms Our study proved that miR-182 participated in the proliferation and invasion of PCa cells via mediating expression of ST6GALNAC5 and established a miR-182/ST6GALNAC5/PI3K/AKT axis in regulation of tumor progression. +lncRNA target 34037089 hsa-mir-515 Stomach Neoplasms DLGAP1-AS1 promoted GC progression through miR5p/MARK4 signaling pathway. +genetics_overexpression_promote 34036868 hsa-mir-1253 Osteosarcoma Overexpression of miR-1253 could significantly inhibit OS cell proliferation, migration, invasion and EMT. +lncRNA target 34036857 hsa-mir-7 Breast Neoplasms Taken together, our data for the first time reveal the biological implication of circ-TPGS2 in BC, it triggers TME reshaping that facilitates BC metastasis through the miR-7/TRAF6/NF-kappaB signalling cascade. +circRNA target 34036483 hsa-mir-1233 Carcinoma, Renal Cell Circ_RPL23A inhibited ccRCC progression by upregulating ACAT2 expression by competitively binding miR-1233, which might provide an in-depth cognition for ccRCC pathogenesis and circ_RPL23A might be a promising biomarker in ccRCC diagnosis and treatment. +genetics_overexpression_promote 34036397 hsa-mir-375 Tinnitus Additionally, miR3753p overexpression via injection of miR3753p mimic reduced the proportion of animals with persistent tinnitus. +other 34036390 hsa-mir-421 Reperfusion Injury Recent studies have demonstrated that microRNA421 (miR421) prevents inflammation in cerebellar ischemia reperfusion injury. +lncRNA target 34036390 hsa-mir-421 Acute Lung Injury In conclusion, the present study demonstrated the protective effect of miR421 on ALI and showed that miR421 attenuates LPSinduced ALI by inhibiting PDCD4 and NFkappaB. +genetics_overexpression_suppress 34036386 hsa-mir-135a Gallbladder Neoplasms In addition, overexpression of miR135a5p significantly inhibited the proliferation and migration of GBCSD cells. +other 34036383 hsa-mir-411 Carcinoma, Pancreatic Ductal In the present study, the expression of PCED1BAS1, microRNA (miR)4113p and hypoxia inducible factor (HIF)1alpha mRNA in 47 cases of PDAC tissues were detected using reverse transcriptionquantitative (RTq)PCR. In conclusion, PCED1BAS1 expression was upregulated in PDAC tissues and cells, and it participated in promoting the proliferation, invasion and EMT of cancer cells by modulating the miR4113p/HIF1alpha axis. +genetics_overexpression_promote 34036380 hsa-mir-153 Retinoblastoma Functional analysis revealed that the overexpression of miR153 inhibited RB cell proliferation, migration and invasion, and promoted the apoptosis of WERIRB1 and Y79 cells. +lncRNA target 34036377 hsa-mir-145 Brain Injuries, Traumatic In conclusion, propofol maintained Th17/Treg balance and reduced inflammation in the rats with TBI via the miR1453p/NFATc2/NFkappaB axis. +genetics_knock down_promote 34036176 hsa-mir-510 Colonic Neoplasms Additionally, the upregulation of miR-510 significantly promoted cell proliferation, migration, and invasion of colon cancer, while its knockdown significantly inhibited these cellular processes. +genetics_overexpression_promote 34035993 hsa-mir-9 Spinal Cord Ischemia In conclusion, overexpression of miR-9 improves neurological outcomes after SCII and might inhibit BSCB disruption, neuroinflammation, and apoptosis through MAP2K3-, or Notch2-mediated signaling pathway in SCII. +genetics_knock down_promote 34035852 hsa-mir-9 Carcinoma, Hepatocellular 3p knockdown enhanced the protein expression level of IGF1R in HCC cells compared with the corresponding control groups. +lncRNA target 34035851 hsa-mir-375 Carcinoma, Renal Cell These results collectively revealed that LUCAT1 promoted the proliferation, migration and invasion of ccRCC by the upregulation of YAP1 via sponging miR-375, which may be used as a potential therapeutic target for ccRCC. +lncRNA target 34035814 hsa-mir-552 Stomach Neoplasms In conclusion, miR-552 serves as a tumor promoter in GC through targeting FOXO1 and regulating EMT and PI3K/AKT pathway. +lncRNA target 34035482 hsa-mir-339 Ovarian Neoplasms These results determined that MAFG-AS1 stimulated the OC malignant progression by upregulating the NFKB1-mediated IGF1 via miR5p, thus highlighting a novel potential therapeutic target against OC. +exosome 34035464 hsa-mir-19b Fractures, Bone Collectively, these results indicate that mesenchymal stem cell-derived exosomal miR-19b represses the expression of WWP1 or Smurf2 and elevates KLF5 expression through the Wnt/beta-catenin signaling pathway, thereby facilitating fracture healing. +transcription factor target 34035375 hsa-mir-101 Breast Neoplasms A higher expression of miR5p predicted better prognosis in patients with HER2+breast cancer (OS: p=0.039; BCSS: p=0.012), supporting the tumor-suppressing role of this miRNA. +circRNA target 34035217 hsa-mir-431 Glioma In conclusion, circ_0001367 functions as an suppressor in glioma by targeting the miR-431/NRXN3 axis and may be a promising therapeutic target against gliomas. +lncRNA target 34034740 hsa-mir-639 Ovarian Neoplasms CONCLUSIONS: circ-PTK2 is an important molecule in regulating the pathogenic processes of ovarian cancer via the miR-639 and FOXC1 regulatory cascade. +other 34034626 hsa-mir-133b Uterine Cervical Neoplasms LncRNA MST1P2 serves as a Cervical Cancer oncogene by sponging with miR-133b. +genetics_knock down_promote 34034499 hsa-mir-212 Stomach Neoplasms 3p knockdown, respectively. +genetics_knock down_promote 34034499 hsa-mir-132 Stomach Neoplasms 3p knockdown, respectively. +genetics_overexpression_suppress 34034455 hsa-mir-144 Adenocarcinoma of Lung 3p in lung adenocarcinoma cell A549 was significantly decreased (P<0.05), and the overexpressed plasmid was successfully transfected (P<0.05). +circulation_biomarker_diagnosis_ns 34034413 hsa-mir-1825 Breast Neoplasms miR-1825 may become a potential serum marker for the diagnosis of breast cancer and monitoring of therapeutic efficacy. +transcription factor target 34033710 hsa-mir-204 Acute Lung Injury Thus, targeting miR3p may be a potential therapeutic strategy for ALI. +genetics_overexpression_promote 34033197 hsa-mir-124 Squamous Cell Carcinoma of Head and Neck 3p overexpression showed opposite effects. +circRNA target 34032607 hsa-mir-502 Osteoarthritis Thus, silencing of hsa_circ_0032131 inhibited the progression of OA by inactivating the miR5p/PRDX3/Trx1/STAT3 axis, which highlights its potential as a therapeutic target for OA. +transcription factor target 34032330 hsa-mir-214 Bone Diseases Increased osteoblastic differentiation by an miR5p inhibitor reveals a new possible strategy for the treatment of bone defect and osteoporosis. +transcription factor target 34032330 hsa-mir-214 Osteoporosis Increased osteoblastic differentiation by an miR5p inhibitor reveals a new possible strategy for the treatment of bone defect and osteoporosis. +lncRNA target 34032148 hsa-mir-515 Carcinoma, Non-Small-Cell Lung Findings in our study support that SNHG3/miR5p/SUMO2 regulatory axis may become a potential therapeutic target for lung cancer. +lncRNA target 34031995 hsa-mir-23 Posterior Segment Ocular Diseases Herein, antisense oligonucleotide-loaded CCMV nanoparticles, intended for intravitreal injection, are evaluated for selective silencing of miR-23, an important target in AMD. +circRNA target 34031947 hsa-mir-152 Triple Negative Breast Neoplasms CONCLUSIONS: Hsa_circ_102229 might serve as a competing endogenous RNA (ceRNA) to modulate PFTK1 expression via regulating miR3p to affect the functions of TNBC cells. +circulation_biomarker_diagnosis_up 34031917 hsa-mir-122 Fatty Liver OBJECTIVE: This study proposed to assess the use of hepatocyte-derived canine familiaris (cfa)-microRNAs (miRNA-122, -34a, and -21) as new diagnostic serum biomarkers of liver steatosis or fibrosis, for which both processes have been implicated in canine cholecystolithiasis. CONCLUSIONS: Serum cfa-miRNA-122, -34a, and -21 expression was significantly upregulated in dogs with cholecystolithiasis with hepatic steatosis or fibrosis compared with control dogs. +circulation_biomarker_diagnosis_up 34031917 hsa-mir-122 Cholecystolithiasis OBJECTIVE: This study proposed to assess the use of hepatocyte-derived canine familiaris (cfa)-microRNAs (miRNA-122, -34a, and -21) as new diagnostic serum biomarkers of liver steatosis or fibrosis, for which both processes have been implicated in canine cholecystolithiasis. CONCLUSIONS: Serum cfa-miRNA-122, -34a, and -21 expression was significantly upregulated in dogs with cholecystolithiasis with hepatic steatosis or fibrosis compared with control dogs. +lncRNA target 34031369 hsa-mir-99b Osteoarthritis Further studies showed that MFG-E8 was inhibited by miR-99b-5p, expression of which was significantly upregulated in OA cartilage, leading to exacerbation of experimental OA partially through activation of NF-kappaB signaling in chondrocytes. +lncRNA target 34031216 hsa-mir-574 Uterine Cervical Neoplasms In conclusion, the LINC00997/miR3p/CUL2 axis contributes to CC cell proliferation, migration, invasion, and autophagy via the activation of MAPK signaling. +circulation_biomarker_diagnosis_ns 34031204 hsa-mir-223 Charcot-Marie-Tooth Disease In addition, the putative Schwann cell miRs (e.g., miR223, -199a, -328, -409, -431) correlate with the recently described transmembrane protease serine 5 (TMPRSS5) protein biomarker that is most highly expressed in Schwann cells and also elevated in CMT1A plasma. +lncRNA target 34030715 hsa-mir-542 Colorectal Neoplasms 3p/TRIB2 axis to inactivate of Wnt/beta-catenin pathway, which providing a novel target for CRC treatment. +lncRNA target 34030529 hsa-mir-31 Arthritis, Rheumatoid In summary, this study demonstrated that FOXD2-AS1 promoted RA progression via regulating the miR +genetics_GWAS 34030497 hsa-mir-100 Prostatic Neoplasms MiR100 was overexpressed in prostate cancer with worse prognostic factors. +genetics_knock down_suppress 34030482 hsa-mir-512 Ovarian Neoplasms Furthermore, the knockdown of CHRAC1 inhibited proliferation, migration, and invasion, and accelerated apoptosis of DDP-resistant OC cells, which was counteracted after the inhibition of miR +other 34030477 hsa-mir-194 Sepsis In conclusion, MIR155HG promotes sepsis progression in an in vitro sepsis model by modulating the miR5p/MEF2A axis. +circulation_biomarker_diagnosis_ns 34030095 hsa-mir-21 Pancreatic Carcinoma Significant distinctions are seen in the frequency shifts for exosomal miR-21 quantitation in clinical plasma samples between pancreatic cancer patients and healthy controls. +lncRNA target 34029939 hsa-mir-199a Carcinoma, Hepatocellular These findings suggest that miR-199a-5p is a potential therapeutic target of HCC, and matrine may represent a promising anti-metastatic medication for HCC therapy. +other 34029828 hsa-mir-495 Breast Neoplasms From eleven selected aberrant miRNAs, four of the miRNAs (hsa-mir-495, hsa-mir-592, hsa-mir-6501, and hsa-mir-937) are significantly detrimental to breast cancer diagnosis and prognosis. +other 34029828 hsa-mir-6501 Breast Neoplasms From eleven selected aberrant miRNAs, four of the miRNAs (hsa-mir-495, hsa-mir-592, hsa-mir-6501, and hsa-mir-937) are significantly detrimental to breast cancer diagnosis and prognosis. +other 34029828 hsa-mir-937 Breast Neoplasms From eleven selected aberrant miRNAs, four of the miRNAs (hsa-mir-495, hsa-mir-592, hsa-mir-6501, and hsa-mir-937) are significantly detrimental to breast cancer diagnosis and prognosis. +other 34029828 hsa-mir-592 Breast Neoplasms From eleven selected aberrant miRNAs, four of the miRNAs (hsa-mir-495, hsa-mir-592, hsa-mir-6501, and hsa-mir-937) are significantly detrimental to breast cancer diagnosis and prognosis. +lncRNA target 34029007 hsa-mir-129-2 Epilepsy, Temporal Lobe 2-3p/GABRA1 pathway may represent a potential target for the prevention and treatment of refractory epilepsy. +other 34028994 hsa-mir-205 Diabetes Mellitus CONCLUSION: MiR5p was identified as relevant microRNA involved in islet dysfunction by interacting with TCF7L2. +lncRNA target 34028890 hsa-mir-103a Stomach Neoplasms Bioinformatics analysis showed that hsa_circ_0001874 harbors miR5p, miR-103a-3p, and miR-107 seed sequences to regulate these three miRNAs and downstream target genes and exert its various biological functions in the carcinogenesis and progression of GC. +lncRNA target 34028890 hsa-mir-107 Stomach Neoplasms Bioinformatics analysis showed that hsa_circ_0001874 harbors miR5p, miR-103a-3p, and miR-107 seed sequences to regulate these three miRNAs and downstream target genes and exert its various biological functions in the carcinogenesis and progression of GC. +lncRNA target 34028890 hsa-mir-593 Stomach Neoplasms Bioinformatics analysis showed that hsa_circ_0001874 harbors miR5p, miR-103a-3p, and miR-107 seed sequences to regulate these three miRNAs and downstream target genes and exert its various biological functions in the carcinogenesis and progression of GC. +exosome 34028833 hsa-mir-29c Coronary Disease EV-IM, ACT and CHR groups expressed more miR5p, miR-29c-3p and miR-125b-5p than the NI group. +exosome 34028833 hsa-mir-125b Coronary Disease EV-IM, ACT and CHR groups expressed more miR5p, miR-29c-3p and miR-125b-5p than the NI group. +exosome 34028833 hsa-mir-155 Coronary Disease EV-IM, ACT and CHR groups expressed more miR5p, miR-29c-3p and miR-125b-5p than the NI group. +exosome 34028833 hsa-mir-125b Nephritis, Interstitial EV-IM, ACT and CHR groups expressed more miR5p, miR-29c-3p and miR-125b-5p than the NI group. +exosome 34028833 hsa-mir-155 Nephritis, Interstitial EV-IM, ACT and CHR groups expressed more miR5p, miR-29c-3p and miR-125b-5p than the NI group. +exosome 34028833 hsa-mir-29c Nephritis, Interstitial EV-IM, ACT and CHR groups expressed more miR5p, miR-29c-3p and miR-125b-5p than the NI group. +transcription factor target 34028661 hsa-mir-33a Vascular Calcification The aim of the present study was to investigate how miR-33a-5p regulated vascular calcification stimulated by ox-LDL. Taken together, these results suggest miR-33a-5p suppresses VSMCs calcification stimulated by ox-LDL via targeting METTL3, highlighting the critical role of miR-33a-5p/METTL3 in vascular calcification. +circRNA target 34027799 hsa-mir-145 Osteoporosis In summary, these results demonstrated that the role of circ_0062582 in osteoporosis is mediated through regulating the expression level of CBFB via miR-145. +genetics_overexpression_suppress 34027766 hsa-mir-429 Acute Kidney Injury Overexpression of miR-429 attenuated apoptosis and elevated cell viability in a CI-AKI cell model via targeting PDCD4 and thus restraining NF-kappaB signalling. +genetics_overexpression_promote 34027641 hsa-mir-193a Ovarian Neoplasms DNM3OS overexpression enhanced OC cell proliferation, migration, and invasion; suppressed E-cadherin protein expression; and facilitated N-cadherin protein expression, while the transfection of miR-193a-3p mimics had the opposite effects. +genetics_overexpression_suppress 34027135 hsa-mir-634 Thyroid Carcinoma, Anaplastic Here, we found that the overexpression of miR-634 synergistically increased lenvatinib-induced cytotoxicity by concurrently downregulating multiple genes related to cytoprotective processes, including ASCT2, a glutamine transporter, in ATC cell lines. +other 34027086 hsa-mir-199a Myocardial Infarction Previous studies have demonstrated that microRNA (miR) 199a-3p protect against MI. These results demonstrate that MMNPs ameliorate left ventricular remodeling and cardiac functions, and protect against MI, suggesting MMNPs containing miR199a-3p is a potential therapeutic approach to treat MI. +lncRNA target 34026693 hsa-mir-223 Cardiovascular Diseases These data also suggest that miR-223 expression may be used as a marker for KD vasculitis pathogenesis and provide a novel therapeutic target. +lncRNA target 34026693 hsa-mir-223 Mucocutaneous Lymph Node Syndrome These data also suggest that miR-223 expression may be used as a marker for KD vasculitis pathogenesis and provide a novel therapeutic target. +target gene 34026654 hsa-mir-125b Triple Negative Breast Neoplasms LncRNA SNHG6/miR-125b-5p/BMPR1B Axis: A New Therapeutic Target for Triple-Negative Breast Cancer. +target gene 34026626 hsa-mir-194 Urinary Bladder Neoplasms Long Noncoding RNA KCNMB2-AS1 Promotes SMAD5 by Targeting miR-3194-3p to Induce Bladder Cancer Progression. +other 34026620 hsa-let-7 Neuroblastoma Using microRNA trapping by RNA affinity purification, we provide a comprehensive view of MYCN-regulatory miRNAs in neuroblastoma-derived cells, confirming a pivotal role of the miR92 cluster and moderate association by the let-7 miRNA family. +transcription factor target 34026326 hsa-mir-204 Alzheimer Disease Silencing of miR-204 could upregulate TRPML1 expression, thus suppressing ROS production and mitochondrial autophagy in AD through STAT3 pathway. +lncRNA target 34026068 hsa-mir-23a Liver Neoplasms MAGI2-AS3 might be a potential therapeutic target for liver cancer owing to its regulation by the miRNA-23a-3p/PTEN axis. +genetics_GWAS 34025683 hsa-mir-129-1 Non-alcoholic Fatty Liver Disease Some of the identified genetic loci are implicated in the pathological pathways of NAFLD, including the lanosterol synthase gene (LSS) associated with glutathione peroxidase activity (Gpx) levels, the mitochondrial pyruvate carrier-1 gene (MPC1) and the sphingolipid transporter-1 gene (SPNS1) associated with hemoglobin levels, the transforming growth factor-beta-induced gene (TGFBI) and the micro-RNA 129-1 (MIR129-1) associated with IL-6 and the granzyme B gene (GZMB) associated with IL-10 levels. +other 34025560 hsa-mir-23b Huntington Disease We found an HD-specific signature: downregulation of hsa-miR-98 (fold change, -1.5, p = 0.0338 HD vs. HS, and fold change, 1.5, p = 0.0045 HD vs. PP) and upregulation of hsa-miR-323b-3p (fold change, 1.5, p = 0.0007 HD vs. HS, and fold change, 1.5, p = 0.0111 HD vs. PP). We were able to confirm that hsa-miR-323b-3p was upregulated in HD and premanifest HD vs. HS and PP: the median values (first-third quartile) were 4.1 (0.9-10.53) and 5.8 (1.9-10.70) vs. 0.69 (0.3-2.75) and 1.4 (0.78-2.70), respectively, p < 0.05. +exosome 34024846 hsa-mir-125b Diabetic Nephropathies It has been suggested that miR-125b is involved in DN. However, the biological functions of exosomal miRNAs, especially miR-125b, in DN are still unclear. +other 34024830 hsa-mir-551a Alzheimer Disease RESULTS: The results showed that two lncRNAs (NEAT1, MIAT), three miRNAs (hsa-miR-551a, hsa-miR-133b and hsa-miR-206), and two mRNA (CXCR4 and GNG3), which are highly related to AD, were preliminarily identified as potential AD biomarkers. +other 34024830 hsa-mir-206 Alzheimer Disease RESULTS: The results showed that two lncRNAs (NEAT1, MIAT), three miRNAs (hsa-miR-551a, hsa-miR-133b and hsa-miR-206), and two mRNA (CXCR4 and GNG3), which are highly related to AD, were preliminarily identified as potential AD biomarkers. +other 34024830 hsa-mir-133b Alzheimer Disease RESULTS: The results showed that two lncRNAs (NEAT1, MIAT), three miRNAs (hsa-miR-551a, hsa-miR-133b and hsa-miR-206), and two mRNA (CXCR4 and GNG3), which are highly related to AD, were preliminarily identified as potential AD biomarkers. +genetics_overexpression_suppress 34024254 hsa-mir-93 Breast Neoplasms Overexpression of miR +circRNA target 34024251 hsa-mir-628 Glioblastoma CONCLUSION: Silencing hsa_circ_0006168 might suppress GBM proliferation and motility via serving as competitive endogenous RNA for miR +lncRNA target 34024242 hsa-mir-338 Carcinoma, Non-Small-Cell Lung 3p per se suppressed NSCLC in vitro and its downregulation diminished the tumour-suppressive role of circ_0010235 blockage in NSCLC cells.miR +target gene 34024225 hsa-mir-212 Cognition Disorders 5p showed a neuroprotective effect in isoflurane-induced cognitive dysfunction rats by inhibiting neuroinflammation. +other 34024202 hsa-mir-22 Venous Thrombosis We therefore hypothesized that hsa_circRNA_000455/hsa-miR3p/NLRP3 may involve in the development of deep vein thrombosis. +other 34024195 hsa-mir-155 Lymphoma, Mantle-Cell 5p levels may be correlated with poor prognosis in MCL. +other 34024195 hsa-mir-34a Lymphoma, Mantle-Cell Identification of miRNA-34a and miRNA-155 as prognostic markers for mantle cell lymphoma. +genetics_overexpression_promote 34024178 hsa-mir-425 Uterine Cervical Neoplasms Additionally, silencing of RAB2B could suppress the growth of cervical cancer cells but its overexpression could rescue the tumor-suppressive effects of miR-425. +exosome 34024119 hsa-mir-381 Spinal Cord Injuries In this paper we report on the effects of MSC-EV-microRNA-381 (miR-381) in a rodent model of SCI. +genetics_overexpression_promote 34024034 hsa-mir-720 Glioma Functional experiments showed that overexpression of miR-720 promotes glioma migration and invasion, while downregulation of miR-720 inhibits glioma migration and invasion. +transcription factor target 34024028 hsa-mir-183 Cerebral Hemorrhage CONCLUSION: BMSC-EVs carried miR5p into db/db-ICH rat brain tissues and repressed the NLRP3 pathway by targeting PDCD4, thus alleviating neuroinflammation after diabetic ICH. +circRNA target 34024023 hsa-mir-612 Esophageal Squamous Cell Carcinoma RESULTS: Circ_0006948 and LASP1 were increased, and miR-3612 was decreased in ESCC tissues and cells. CONCLUSION: Circ_0006948 boosted ESCC progression partly by regulating the miR-3612/LASP1 axis, providing an underlying therapeutic target for the ESCC treatment. +genetics_overexpression_promote 34023860 hsa-mir-200b Prostatic Neoplasms Moreover, mechanistic analysis revealed that PPARG2 overexpression induced increased expression level of miR-200b-3p, which targeted 3' UTR of the downstream targets DNMT3A/3B, and facilitated interaction with demethylated AKAP12 gene promoter and suppressed cell proliferation in PCA. +lncRNA target 34023817 hsa-mir-107 Carcinoma, Hepatocellular In conclusion, our study demonstrated that FEZF1-AS1 promoted HCC progression through activating Wnt/beta-catenin signaling by targeting miR-107, which provided a novel target for the therapy of HCC. +target gene 34023560 hsa-mir-348 Breast Neoplasms Hsa_circ_0092276 promotes doxorubicin resistance in breast cancer cells by regulating autophagy via miR-348/ATG7 axis. +genetics_knock down_promote 34023283 hsa-mir-543 Uterine Cervical Neoplasms We also found that overexpression of miR-543 impeded proliferation, cell cycle process, migration, invasion, and glycolysis while induced apoptosis in SCC cells by targeting FNDC3B. +circRNA target 34022910 hsa-mir-194 Esophageal Squamous Cell Carcinoma 5p/JMJD1C axis, providing a promising therapeutic target for ESCC chemotherapy. +lncRNA target 34022794 hsa-mir-501 Endometrial Neoplasms CONCLUSIONS: MiR-501, which functions as an oncomir in endometrial cancer, might be a potential therapeutic target in high grade endometrial cancer. +genetics_overexpression_promote 34022711 hsa-mir-16 Fibrosis, Skin 5p-overexpressing keratinocytes-derived exosomes significantly enhanced miR +lncRNA target 34022583 hsa-mir-148a Ischemic Stroke 3p, and miR-19a through SVM algorithm has the potential to serve as a feasible approach to promote the diagnosis of IS. +lncRNA target 34022583 hsa-mir-19a Ischemic Stroke 3p, and miR-19a through SVM algorithm has the potential to serve as a feasible approach to promote the diagnosis of IS. +lncRNA target 34022583 hsa-mir-342 Ischemic Stroke 3p, and miR-19a through SVM algorithm has the potential to serve as a feasible approach to promote the diagnosis of IS. +circulation_biomarker_diagnosis_up 34022359 hsa-mir-155 Echinococcosis The results also revealed that miR-146a and miR-155 upregulation in the plasma leads to the development of novel biomarkers for echinococcosis. +exosome 34022068 hsa-mir-942 Colorectal Neoplasms CONCLUSION: Our data revealed that exosomal circEPB41L2 sponged miR +genetics_overexpression_promote 34021861 hsa-mir-4306 Esophageal Squamous Cell Carcinoma Furthermore, we explored the molecular mechanism of effects of miR-4306 and found that miR-4306 inhibited the expression of SIX3 by interaction with SIX3 3'UTR in ESCC cells, and SIX3 overexpression significantly reversed the effect of miR +genetics_knock down_suppress 34021822 hsa-mir-646 Carcinoma, Hepatocellular Further, FZD4 was a target of miR-646, and its overexpression could invert the inhibition effect of miR-646 mimic on HCC progression. +lncRNA target 34021567 hsa-mir-195 Incontinentia Pigmenti Circ_0038467 silencing protected MRC-5 cells from LPS-induced injury by miR5p/TLR4 axis through NF-kappaB pathway, providing a theoretical basis for circRNA-directed IP therapy. +genetics_overexpression_promote 34021445 hsa-mir-9 Mouth Neoplasms We have investigated the overexpression of miR +circRNA target 34021307 hsa-mir-527 Urinary Bladder Neoplasms Lastly, circ_0001495 was found to promote the proliferation, migration and invasion of BCa cells in vitro through the miR-527/Robo1 axis and promote the growth and metastasis of BCa tumors in vivo. Altogether, findings in our study highlight the promoting role of circ_0001495 in the progression of BCa by increasing Robo1 via sponging miR-527, representing a promising target for BCa management. +lncRNA target 34021273 hsa-mir-34b Colonic Neoplasms Collectively, miR-34b-5p targets HuR and miR-34b-5p binds to OIP5-AS1 with HuR, thus inhibiting OIP5-AS1 and PI3K/Akt pathway and CC progression. +transcription factor target 34021255 hsa-mir-625 Urinary Bladder Neoplasms RBM24-regulated BC cell proliferation was moderated via the Runx1t1/TCF4/miR +genetics_knock down_promote 34021124 hsa-mir-187 Pituitary Neoplasms TUG1 knockdown inhibited cell proliferation, invasion, migration, and epithelial-mesenchymal transition, promoted apoptosis, and regulated the expression of NF-kappaB p65 and inhibitor of kappaB (IkappaB)-alpha in PA cells lines in vitro, and also inhibited tumor growth in vivo, and these effects were reversed by miR +lncRNA target 34020639 hsa-mir-488 Squamous Cell Carcinoma of Head and Neck MiR-488 was a target of circ_0000745, and circ_0000745 downregulation suppressed OSCC development by enriching miR-488. CONCLUSIONS: Circ_0000745 regulated the expression of CCND1 partly by acting as miR-488 sponge and interacting with HuR protein, thus promoting the progression of OSCC. +other 34020619 hsa-mir-1228 Uterine Cervical Neoplasms CONCLUSION: From above concern, it can conclude that hsa_circ_0000301/hsa-miR3p/IRF4 may be involved in the occurrence and development of cervical cancer. +other 34020433 hsa-mir-21 Breast Neoplasms Also, the expression pattern of miR-21, miR-29a, and Bax/Bcl-2 ratio in KMBC/71 and MCF-7 mammospheres was different in response to GO-Cur and GQDs-Cur. +other 34020433 hsa-mir-29a Breast Neoplasms Also, the expression pattern of miR-21, miR-29a, and Bax/Bcl-2 ratio in KMBC/71 and MCF-7 mammospheres was different in response to GO-Cur and GQDs-Cur. +epigenetics 34020253 hsa-mir-29a Scleroderma, Systemic Our study highlights the therapeutic role of miR-29a-3p in SSc and the importance of regulating methylation and apoptosis. +other 34020163 hsa-mir-21 Ovarian Failure, Premature The study results inferred downregulation in the expression levels of miR-21 in ovarian tissues of PCOS patients and KGN cells, when compared with unaffected ovarian tissues and IOSE80 (human ovarian surface epithelial cell line). +other 34020163 hsa-mir-21 Polycystic Ovary Syndrome The study results inferred downregulation in the expression levels of miR-21 in ovarian tissues of PCOS patients and KGN cells, when compared with unaffected ovarian tissues and IOSE80 (human ovarian surface epithelial cell line). +lncRNA target 34020142 hsa-mir-7 Carcinoma, Hepatocellular 5p could act as a tumor inhibitory factor in HCC. +transcription factor target 34019979 hsa-mir-181b Pituitary Diseases To conclude, butyrate prevents endothelial dysfunction in atherosclerosis by reducing endothelial NOX2 expression and ROS production via the PPARdelta/miR-181b pathway. +genetics_GWAS 34019714 hsa-mir-132 Carcinoma, Hepatocellular The recovery experiments demonstrated that downregulation of miR-132/212 markedly eliminate the antitumor effects mediated by RBM5-AS1 silencing in HCC cells. The data of this work illustrate that RBM5-AS1 acts as an epigenetic regulator to promote the HCC progression by repressing miR-132/212 expressions, which would provide a new insight for understanding the action mechanism of RBM5-AS1 in HCC development. +genetics_GWAS 34019714 hsa-mir-212 Carcinoma, Hepatocellular The recovery experiments demonstrated that downregulation of miR-132/212 markedly eliminate the antitumor effects mediated by RBM5-AS1 silencing in HCC cells. The data of this work illustrate that RBM5-AS1 acts as an epigenetic regulator to promote the HCC progression by repressing miR-132/212 expressions, which would provide a new insight for understanding the action mechanism of RBM5-AS1 in HCC development. +other 34019567 hsa-mir-222 Thyroid Cancer, Papillary Especially MiR-222 and miR-146b may be prime candidates for the diagnosis of PTC in Asian population. +other 34019567 hsa-mir-146b Thyroid Cancer, Papillary Especially MiR-222 and miR-146b may be prime candidates for the diagnosis of PTC in Asian population. +other 34019487 hsa-mir-22 Carcinoma, Hepatocellular In conclusion, this study suggests that chronic alcohol exposure promotes HCC progression and beta-catenin/miR3p/TET2 regulatory axis plays an important role in alcohol-promoted HCC malignancy. +lncRNA target 34018840 hsa-mir-200b Liver Neoplasms The lncRNA XIST promoted liver cancer cell proliferation, migration, and invasion in vitro, and acted as a molecular sponge for miR-200b-3p, and also regulated the expression of ZEB1/2 via miR-200b-3p. CONCLUSION: The lncRNA XIST is an oncogenic lncRNA that promotes liver cancer metastasis, and its pro-metastatic phenotype can be partially attributed to the lncRNA XIST/miR-200b-3p/ZEB1/2 signaling axis. +genetics_overexpression_promote 34018619 hsa-mir-630 Esophageal Squamous Cell Carcinoma CONCLUSION: miR-630 overexpression can reduce EC cell invasion and migration, showing a possible key role of miR-630 in EC diagnosis and treatment in the future. +genetics_knock down_suppress 34018345 hsa-mir-221 Diabetic Neuropathies Furthermore, knockdown of miR-221 remarkably decreased the expression of PEG2, BK, IL-6, IL-1beta, and TNF-alpha in both STZ-treated DPN rats and high glucose-induced SH-SY5Y cells, which was reversed by inhibition of SOCS3. +transcription factor target 34018309 hsa-mir-193b Parkinson Disease Our findings also revealed that miR-193b functions in PD development, possibly through regulating PGC-1alpha/FNDC5/BDNF pathway, suggesting miR-193b as a potential biomarker for PD diagnosis. +lncRNA target 34018092 hsa-mir-124 Esophageal Squamous Cell Carcinoma By modulating miR-124/PD-L1 axis, silencing circ-VIM and applying sevoflurane both inhibited immune escape and multiple oncogenic activities of EC in vitro, and suppressed xenograft growth and lung metastases in vivo. +genetics_knock down_promote 34017919 hsa-mir-1229 Glioma In vivo knockdown of circ_0037655 also suppressed glioma tumorigenesis by acting on the miR +lncRNA target 34017686 hsa-mir-146a Osteosarcoma MicroRNA analysis of SEVs from different malignant human osteosarcomas revealed that miR-146a-5p was involved in the inhibition of osteoclastogenesis. +target gene 34017681 hsa-mir-454 Colorectal Neoplasms MiR-454-3p Promotes Oxaliplatin Resistance by Targeting PTEN in Colorectal Cancer. +other 34017558 hsa-mir-222 Coronary Disease OBJECTIVE: To explore the changes in miR-221 and miR-222 before and after interventional therapy of coronary heart disease and their relationship with inflammatory factors and prognosis. CONCLUSION: The levels of miR-221 and miR-222 in patients with coronary heart disease significantly increased and they were closely correlated with the inflammatory factors, NT-proBNP and LVEF%. +other 34017558 hsa-mir-221 Coronary Disease OBJECTIVE: To explore the changes in miR-221 and miR-222 before and after interventional therapy of coronary heart disease and their relationship with inflammatory factors and prognosis. CONCLUSION: The levels of miR-221 and miR-222 in patients with coronary heart disease significantly increased and they were closely correlated with the inflammatory factors, NT-proBNP and LVEF%. +genetics_overexpression_promote 34017500 hsa-mir-429 Carcinoma, Pancreatic Ductal Overexpressed miR-429 restricted the mobility and proliferation of PDAC cells by restricting EMT, while down-regulated miR-429 had the opposite effect. +circulation_biomarker_prognosis_ns 34017498 hsa-mir-1269 Lung Neoplasms METHODS: The miR-1269 expressions in the peripheral blood of LC patients, benign pulmonary disease (BPD) patients, and healthy controls were measured using qRT-PCR. +genetics_overexpression_promote 34017441 hsa-mir-21 Lung Injury 5p overexpression on the lung tissues of HILI rats can be partially blocked by MAP2K3 overexpression. +circulation_biomarker_diagnosis_down 34017415 hsa-mir-20 Smoke Inhalation Injury CONCLUSION: Aerosol inhalation of edaravone in advance can reduce the levels of inflammatory factors and oxidative stress indexes in serum of smoke inhalation injury rats, thus protecting PF, which may be related to the down-regulation of miR-320 by edaravone. +lncRNA target 34017411 hsa-mir-195 Carcinoma, Non-Small-Cell Lung 5p suppresses FOXK1 and accelerates apoptosis of tumor cells, which may serve as an therapeutic target for the treatment of NSCLC. +tissue_expression_ns 34017408 hsa-mir-663b Burns A deficiency of HULC promotes the proliferation, invasion, and ECM synthesis of HSF cells with thermal injury; HULC functions as a ceRNA of miR-663b. +exosome 34017395 hsa-mir-28 Myocardial Infarction Furthermore, exogenous exosomal miR +lncRNA target 34017389 hsa-mir-20 Hypoxia 3p plays a certain role in the progression of hypoxic PH via KLF5 and HIF1alpha and might be a potent therapeutic tool for PH. +lncRNA target 34017389 hsa-mir-20 Hypertension, Pulmonary 3p plays a certain role in the progression of hypoxic PH via KLF5 and HIF1alpha and might be a potent therapeutic tool for PH. +other 34017389 hsa-mir-20 Diarrhea 5, With Tufting Enteropathy, Congenital The results indicated that miR3p was downregulated in hypoxia-exposed rat PH models, hypoxia-induced PASMCs and chronic thromboembolic pulmonary hypertension (CTEPH) patients. +genetics_knock down_promote 34017387 hsa-mir-363 Carcinoma, Renal Cell The expression of Snail1, Vimentin, N-cadherin, and E-cadherin in RCC cells was measured, and then the effect of loss-of-function of miR-363 and gain-of-function of Snail on RCC cells were analyzed. +target gene 34017385 hsa-mir-214 Prostatic Neoplasms miR-214-5p targeted by LncRNA DANCR mediates TGF-β signaling pathway to accelerate proliferation, migration and inhibit apoptosis of prostate cancer cells. +genetics_knock down_promote 34017382 hsa-mir-338 Pancreatic Carcinoma The inhibitory effects of circPCDH10 knockdown on PC cells could be notably reversed by miR +other 34017372 hsa-mir-423 Diabetic Nephropathies 5p-USF2 axis. +genetics_overexpression_promote 34017210 hsa-mir-19b Colonic Neoplasms RESULTS: The miR-19b was overexpressed and NR3C1 was decreased in colon cancer tissue and cell lines (SW480 and DLD-1). +other 34017077 hsa-mir-211 high grade glioma The novel feedback loop among FMR1, circCHAF1A, miR5p, and HOXC8 in GSCs can facilitate the proliferation and tumorigenesis of glioma and GSCs. +exosome 34016964 hsa-mir-503 Breast Neoplasms Exosomal microRNA-503-3p derived from macrophages represses glycolysis and promotes mitochondrial oxidative phosphorylation in breast cancer cells by elevating DACT2. +other 34016844 hsa-mir-27a Ventricular Dysfunction, Right As the current treatments cannot prevent the progression of the disease, we investigated whether 3 plant derivatives, namely perillyl alcohol (PA), quercetin (QS), and berberine (BBR), can improve RV function and affect the expression of miR-204, miR-27a, and biochemical factors in monocrotaline-induced PAH (MCT-PAH). +other 34016844 hsa-mir-27a Pulmonary Arterial Hypertension As the current treatments cannot prevent the progression of the disease, we investigated whether 3 plant derivatives, namely perillyl alcohol (PA), quercetin (QS), and berberine (BBR), can improve RV function and affect the expression of miR-204, miR-27a, and biochemical factors in monocrotaline-induced PAH (MCT-PAH). +circulation_biomarker_diagnosis_up 34016842 hsa-mir-340 von Hippel-Lindau Disease The expression levels of miR-340 and von Hippel-Lindau tumor suppressor (VHL) in VSMCs induced by platelet-derived growth factor-BB or fetal bovine serum were measured by q-polymerase chain reaction. +genetics_knock down_promote 34016832 hsa-mir-30 Stomach Neoplasms Knockdown of circ_ASAP2 promoted DDP sensitivity and suppressed malignant behaviors of DDP-resistant gastric cancer cells through targeting the miR3p/NT5E axis. +other 34016788 hsa-mir-454 Pituitary Neoplasms 3p/TNF-alpha in BIPAs. +other 34015968 hsa-mir-139 Intervertebral Disc Degeneration In conclusion, lncRNA H19 facilitated the autophagy and apoptosis of DNPCs by the miR3p/CXCR4/NF-kappaB axis, thereby aggravating IDD. +genetics_overexpression_suppress 34015764 hsa-mir-588 Squamous Cell Carcinoma of Head and Neck The overexpression of CXCR4 or miR-588 inhibitor could reverse circABCB10 depletion-attenuated malignant phenotypes of LSCC cells. +lncRNA target 34015763 hsa-mir-17 Intervertebral Disc Degeneration Thus, we conclude that circITCH promotes ECM degradation in IDD by activating Wnt/beta-catenin through miR5p/SOX4 signaling. +other 34015762 hsa-mir-335 Osteosarcoma The LOC100129620/miR3p/CDK6 signaling pathway promotes the metastasis of osteosarcoma by regulating the proliferation of osteosarcoma cells, angiogenesis, and macrophage polarization. +transcription factor target 34015413 hsa-mir-187 Brain Ischemia Our findings demonstrate that the inhibition of miR1873p attenuated I/Rinduced cerebral injury by regulating seipin-mediated ERS. +other 34015321 hsa-mir-206 Glioblastoma Further, miR-206/Twist axis is involved in EZH2-regulated malignancy of GBM cells. +other 34014027 hsa-mir-335 Obesity Transcriptomic analyses of miRNA and mRNA in the epididymal WAT of obese rats using microarrays revealed that DATS decreased miRNA-335 expression and normalized the obesity-related mRNA transcriptomic signatures in epididymal WAT. +transcription factor target 34014023 hsa-mir-17 Diabetic Nephropathies 5p inhibition alleviates the apoptosis and fibrosis in high glucose-treated HMCs by targeting KIF23 activating Wnt/beta-catenin signaling. +circulation_biomarker_diagnosis_up 34013701 hsa-mir-29c Acromegaly CONCLUSION: Plasma miR-29c-3p expression level is downregulated in patients with acromegaly, and this is more pronounced in patients with inadequate control. +other 34013455 hsa-let-7a Neurotic Disorders 3p, and miR-1202) were measured using real-time PCR. +other 34013455 hsa-mir-34a Neurotic Disorders 3p, and miR-1202) were measured using real-time PCR. +other 34013455 hsa-mir-132 Neurotic Disorders 3p, and miR-1202) were measured using real-time PCR. +other 34013455 hsa-mir-17 Sexually Transmitted Diseases Although a larger-scale analysis is needed due to the small number of subjects, these findings suggest that miR5p in NEVs is a potential biomarker for StD. +other 34013455 hsa-mir-26b Neurotic Disorders 3p, and miR-1202) were measured using real-time PCR. +other 34013455 hsa-mir-17 Neurotic Disorders 3p, and miR-1202) were measured using real-time PCR. +lncRNA target 34013364 hsa-mir-17 Arthritis, Rheumatoid Long noncoding RNA (lncRNA) LOC100912373 was identified as a key gene related to RA and has been proven to interact with miR175p, in order to regulate the pyruvate dehydrogenase kinase 1 and protein kinase B axis (PDK1/AKT axis). The present study aimed to determine whether AST may treat RA through the interaction between lncRNA LOC100912373 and the miR175p/PDK1 axis. +genetics_overexpression_promote 34013042 hsa-mir-28 Carcinoma, Non-Small-Cell Lung 5p overexpression-mediated influences in NSCLC cells were partly overturned by the addition of HIF-1alpha overexpression plasmid. +circulation_biomarker_diagnosis_ns 34012792 hsa-mir-4286 Carcinoma, Non-Small-Cell Lung miR-4286 showed promise as a blood-based diagnostic biomarker that could distinguish between adenocarcinoma and SqCC histologies. +other 34012792 hsa-mir-34a Carcinoma, Non-Small-Cell Lung RESULTS: Differential expression of a 5-miR signature (miR-30a-3p, miR-30b-5p, miR-30c-5p, miR-34a-5p, miR-4286) demonstrated their ability to distinguish between normal and tumour lung tissue and between NSCLC histologies. +other 34012636 hsa-mir-625 Esophageal Neoplasms Long non-coding RNA small nucleolar RNA host gene 7 facilitates the proliferation, migration, and invasion of esophageal cancer cells by regulating microRNA-625. +lncRNA target 34012590 hsa-mir-132 Carcinoma, Non-Small-Cell Lung 3p and restrained the development of tumor cells in NSCLC, the effects of which were attenuated via KLF7 over-expression. +circulation_biomarker_diagnosis_ns 34012511 hsa-mir-520e Exanthema RESULTS: In our cohort of patients treated with EGFR inhibiting monoclonal antibodies, miR-21 and miR-520e serum concentrations were negatively correlated with severity of skin rash (p-value 0.000582 and 1.53e-07 linear-trend-test) whereas for miR-31, a positive correlation was observed (p-value 9.01e-06 linear-trend-test). CONCLUSIONS: This suggests that miR-21, miR-31 and miR-520e expression might be a treatment dependent marker for EGFRI induced skin rash. +circulation_biomarker_diagnosis_ns 34012511 hsa-mir-21 Exanthema RESULTS: In our cohort of patients treated with EGFR inhibiting monoclonal antibodies, miR-21 and miR-520e serum concentrations were negatively correlated with severity of skin rash (p-value 0.000582 and 1.53e-07 linear-trend-test) whereas for miR-31, a positive correlation was observed (p-value 9.01e-06 linear-trend-test). CONCLUSIONS: This suggests that miR-21, miR-31 and miR-520e expression might be a treatment dependent marker for EGFRI induced skin rash. +circulation_biomarker_diagnosis_ns 34012511 hsa-mir-1 Exanthema RESULTS: In our cohort of patients treated with EGFR inhibiting monoclonal antibodies, miR-21 and miR-520e serum concentrations were negatively correlated with severity of skin rash (p-value 0.000582 and 1.53e-07 linear-trend-test) whereas for miR-31, a positive correlation was observed (p-value 9.01e-06 linear-trend-test). CONCLUSIONS: This suggests that miR-21, miR-31 and miR-520e expression might be a treatment dependent marker for EGFRI induced skin rash. +target gene 34012271 hsa-mir-338 Ovarian Neoplasms CircHIPK2 Contributes to DDP Resistance and Malignant Behaviors of DDP-Resistant Ovarian Cancer Cells Both in vitro and in vivo Through circHIPK2/miR-338-3p/CHTOP ceRNA Pathway. +genetics_knock down_suppress 34012268 hsa-mir-873 Stomach Neoplasms HNRNPK overexpression reversed the inhibitory impact of miR +lncRNA target 34012023 hsa-mir-1252 Osteoporosis In summary, PAX8-AS1 suppressed the viability and activated the autophagy of osteoblasts via the miR5p/GNB1 axis in OP. +circulation_biomarker_diagnosis_ns 34011306 hsa-mir-4718 Drug-Induced Kidney Injury The baseline expression of miR-3168 (p = 0.0456, OR = 1.03, 95% CI: 1.00-1.06) and miR-4718 (p = 0.0388, OR = 1.56, 95% CI: 1.03-2.46) were associated with an increased risk of nephrotoxicity, whereas miR-6125 showed a trend (p = 0.0618, OR = 1.73, 95% CI: 0.98-3.29). CONCLUSIONS: We have provided evidence of baseline plasmatic expression of miR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity. +circulation_biomarker_diagnosis_ns 34011306 hsa-mir-3168 Head and Neck Neoplasms The baseline expression of miR-3168 (p = 0.0456, OR = 1.03, 95% CI: 1.00-1.06) and miR-4718 (p = 0.0388, OR = 1.56, 95% CI: 1.03-2.46) were associated with an increased risk of nephrotoxicity, whereas miR-6125 showed a trend (p = 0.0618, OR = 1.73, 95% CI: 0.98-3.29). CONCLUSIONS: We have provided evidence of baseline plasmatic expression of miR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity. +circulation_biomarker_diagnosis_ns 34011306 hsa-mir-4718 Head and Neck Neoplasms The baseline expression of miR-3168 (p = 0.0456, OR = 1.03, 95% CI: 1.00-1.06) and miR-4718 (p = 0.0388, OR = 1.56, 95% CI: 1.03-2.46) were associated with an increased risk of nephrotoxicity, whereas miR-6125 showed a trend (p = 0.0618, OR = 1.73, 95% CI: 0.98-3.29). CONCLUSIONS: We have provided evidence of baseline plasmatic expression of miR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity. +circulation_biomarker_diagnosis_ns 34011306 hsa-mir-6125 Head and Neck Neoplasms The baseline expression of miR-3168 (p = 0.0456, OR = 1.03, 95% CI: 1.00-1.06) and miR-4718 (p = 0.0388, OR = 1.56, 95% CI: 1.03-2.46) were associated with an increased risk of nephrotoxicity, whereas miR-6125 showed a trend (p = 0.0618, OR = 1.73, 95% CI: 0.98-3.29). CONCLUSIONS: We have provided evidence of baseline plasmatic expression of miR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity. +circulation_biomarker_diagnosis_ns 34011306 hsa-mir-6125 Drug-Induced Kidney Injury The baseline expression of miR-3168 (p = 0.0456, OR = 1.03, 95% CI: 1.00-1.06) and miR-4718 (p = 0.0388, OR = 1.56, 95% CI: 1.03-2.46) were associated with an increased risk of nephrotoxicity, whereas miR-6125 showed a trend (p = 0.0618, OR = 1.73, 95% CI: 0.98-3.29). CONCLUSIONS: We have provided evidence of baseline plasmatic expression of miR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity. +circulation_biomarker_diagnosis_ns 34011306 hsa-mir-3168 Drug-Induced Kidney Injury The baseline expression of miR-3168 (p = 0.0456, OR = 1.03, 95% CI: 1.00-1.06) and miR-4718 (p = 0.0388, OR = 1.56, 95% CI: 1.03-2.46) were associated with an increased risk of nephrotoxicity, whereas miR-6125 showed a trend (p = 0.0618, OR = 1.73, 95% CI: 0.98-3.29). CONCLUSIONS: We have provided evidence of baseline plasmatic expression of miR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity. +lncRNA target 34011046 hsa-mir-34a Neuroblastoma With all these evidences, we determined that miRNA-34a-5p regulated Wnt/beta-catenin pathway by targeting SOX4.In conclusion, our study demonstrates that miRNA-34a-5p can inhibit the over-activation of the Wnt/beta-catenin signaling pathway via targeting SOX4 and further regulate proliferation, invasion of neuroblastoma cells. +lncRNA target 34010654 hsa-mir-199a Rett Syndrome Moreover, miR-199a expression and treatment with BMP inhibitors rectify the differentiation of RTT patient-derived NS/PCs and development of brain organoids, respectively, suggesting that facilitation of BMP signaling accounts for the impaired RTT brain development. Our study illuminates the molecular pathology of RTT and reveals the MeCP2/miR-199a/Smad1 axis as a potential therapeutic target for RTT. +other 34010598 hsa-mir-107 Colorectal Neoplasms Taken together, our results suggest that the miR-107/MCM7/PAK2 pathway may participate in cancer progression and that MCM7 may serve as a prognostic biomarker in CRC. +transcription factor target 34010470 hsa-mir-98 Alzheimer Disease 5p suppressed alpha7 nAChR expression through directly binding to the 3'UTR of mRNA. +other 34010469 hsa-mir-145 Eunuchism These findings demonstrate that SC-derived miR5p plays a significant role in regulating the functions of Leydig cells and may therefore serve as a diagnostic biomarker for male hypogonadism developmental abnormalities during puberty. +genetics_knock down_promote 34010066 hsa-mir-579 Kidney Diseases What's more, overexpression of GAS5, or knockdown of miR +genetics_knock down_promote 34010066 hsa-mir-579 Sepsis What's more, overexpression of GAS5, or knockdown of miR +genetics_overexpression_promote 34009856 hsa-mir-9 Myocardial Infarction CircJARID2 overexpression contributed to the hypoxia-induced H9c2 cell injury by sponging miR5p to upregulate BNIP3 expression, showing a novel molecular network of MI pathomechanism. +other 34009437 hsa-mir-195 Obesity CONCLUSIONS: In obese pre-diabetics', metformin significantly reduces inflammation/oxidative stress, and miR-195 and miR-27, with reduction in LVM, IMT. +other 34009437 hsa-mir-195 Diabetes Mellitus, Type 2 CONCLUSIONS: In obese pre-diabetics', metformin significantly reduces inflammation/oxidative stress, and miR-195 and miR-27, with reduction in LVM, IMT. +other 34009437 hsa-mir-27 Diabetes Mellitus, Type 2 CONCLUSIONS: In obese pre-diabetics', metformin significantly reduces inflammation/oxidative stress, and miR-195 and miR-27, with reduction in LVM, IMT. +other 34009437 hsa-mir-27 Obesity CONCLUSIONS: In obese pre-diabetics', metformin significantly reduces inflammation/oxidative stress, and miR-195 and miR-27, with reduction in LVM, IMT. +lncRNA target 34009012 hsa-mir-519a Ovarian Neoplasms Conclusion: PARP1, a target gene of miR-519a-3p, promoted the migration, invasion, and tube formation of OC cells, providing a possible therapeutic target for treatment of OC patients. +circulation_biomarker_diagnosis_ns 34008755 hsa-mir-141 Neonatal Sepsis In conclusion, serum decreased miR-141 expression served as a candidate diagnostic biomarker of neonatal sepsis. +lncRNA target 34008749 hsa-mir-29a Carcinoma, Hepatocellular Furthermore, KCNQ1OT1 exerted tumor promotion in HCC cells via suppressing miR-29a-3p to regulate CBX3 expression. +lncRNA target 34008270 hsa-mir-124 Cataract, Age-Related CONCLUSION: This study revealed that miRNA-124 promotes LEC apoptosis in ARC by upregulating mFas through targeted inhibition of PTB. +transcription factor target 34008206 hsa-mir-124 Neuralgia Targeting miR3p might be a promising therapeutic strategy in the treatment of chronic pain. +transcription factor target 34007335 hsa-mir-135a Depression In conclusion, the findings of the present study indicate that miR-135a may be a novel potential target for the treatment of depression. +circulation_biomarker_diagnosis_ns 34007326 hsa-mir-23a Pulmonary Disease, Chronic Obstructive Furthermore, the area under the curve values of the three exo-miRNAs (miR-23a, miR-221 and miR-574) for COPD diagnosis were 0.776 [95% confidence interval (CI), 0.669-0.882], 0.688 (95% CI, 0.563-0.812) and 0.842 (95% CI, 0.752-0.931), respectively. In conclusion, the three circulating exosomal miRNAs (miR-23a, miR-221 and miR-574) may serve as novel circulating biomarkers for the diagnosis of COPD. +circulation_biomarker_diagnosis_ns 34007326 hsa-mir-574 Pulmonary Disease, Chronic Obstructive Furthermore, the area under the curve values of the three exo-miRNAs (miR-23a, miR-221 and miR-574) for COPD diagnosis were 0.776 [95% confidence interval (CI), 0.669-0.882], 0.688 (95% CI, 0.563-0.812) and 0.842 (95% CI, 0.752-0.931), respectively. In conclusion, the three circulating exosomal miRNAs (miR-23a, miR-221 and miR-574) may serve as novel circulating biomarkers for the diagnosis of COPD. +circulation_biomarker_diagnosis_ns 34007326 hsa-mir-221 Pulmonary Disease, Chronic Obstructive Furthermore, the area under the curve values of the three exo-miRNAs (miR-23a, miR-221 and miR-574) for COPD diagnosis were 0.776 [95% confidence interval (CI), 0.669-0.882], 0.688 (95% CI, 0.563-0.812) and 0.842 (95% CI, 0.752-0.931), respectively. In conclusion, the three circulating exosomal miRNAs (miR-23a, miR-221 and miR-574) may serve as novel circulating biomarkers for the diagnosis of COPD. +genetics_knock down_promote 34007324 hsa-mir-141 Cardiomyopathies In summary, the present study indicated that upregulated SGLT2 expression in cardiac fibrosis following MI was regulated by miR-141 and SGLT2 that knockdown reduced cardiac fibrosis and improved cardiac function after MI. +genetics_knock down_promote 34007313 hsa-mir-378 Esophageal Squamous Cell Carcinoma miR-378 mimic and miR-378 inhibitor was transfected into ESCC cells to overexpress or knockdown miR-378 expression levels in ESCC cells. +lncRNA target 34007276 hsa-mir-340 Carcinoma, Hepatocellular 5p, which has been reported to directly inhibit ATF7 expression in HCC cells. +other 34007244 hsa-mir-6869 Diabetes, Gestational 5p is involved in maintaining placental microenvironment balance by preventing from inflammation and inducing M2 macrophages in gestational diabetes mellitus. +other 34007214 hsa-mir-7 Ovarian Neoplasms LNC00115 Mediates Cisplatin Resistance by Regulating the miR-7/ERK Signalling Pathway in Ovarian Cancer. +lncRNA target 34007212 hsa-mir-138 Stomach Neoplasms 5p, the inhibition of which could attenuate silenced circ_CORO1C-induced inhibitory effects on GC progression. +lncRNA target 34007211 hsa-mir-4319 Carcinoma, Non-Small-Cell Lung Furthermore, PCAT18 silencing inhibited NSCLC cell proliferation, migration and invasion, while co-transfection with a miR-4319 inhibitor reversed these biological effects, and miR-4319 inhibited NSCLC growth in vivo. CONCLUSION: In conclusion, these findings demonstrated that PCAT18 promoted NSCLC development by sponging miR-4319. +tissue_expression_ns 34007200 hsa-mir-223 Panniculitis, Peritoneal MiR-223 deficiency also markedly aggravated inflammatory cells infiltration and cytokines release including interleukin (IL)-1beta, IL-6 and monocyte chemotactic protein-1 (MCP-1) in the air pouch and peritonitis models. +transcription factor target 34007200 hsa-mir-223 Dyssegmental dysplasia, Rolland-Desbuquois type CONCLUSION: MiR-223 was down-regulated in gout patients and miR-223 deficiency exacerbated inflammatory response in diverse murine models, suggesting that up-regulation of miR-223 could be a potential therapeutic strategy for alleviating gouty inflammation. +transcription factor target 34007200 hsa-mir-223 Gout CONCLUSION: MiR-223 was down-regulated in gout patients and miR-223 deficiency exacerbated inflammatory response in diverse murine models, suggesting that up-regulation of miR-223 could be a potential therapeutic strategy for alleviating gouty inflammation. +target gene 34007185 hsa-mir-422a Thyroid Neoplasms Long Noncoding RNA CCDC26 Promotes Thyroid Cancer Malignant Progression via miR-422a/EZH2/Sirt6 Axis. +lncRNA target 34007135 hsa-mir-128 Pancreatic Carcinoma Mechanistically, TP73-AS1 was validated to promote PC progression through GOLM1 upregulation by competitively binding to miR +lncRNA target 34006929 hsa-mir-378c Atherosclerosis Our results provided a better understanding of atherosclerosis pathophysiology and potential therapeutic management by targeting miR-378c-Samd1 circuit. +transcription factor target 34006907 hsa-mir-23a Hematologic Neoplasms Here we show that inhibition of miRNAs -503 and -23a, alone or in combination, enhances tumor proliferation in hepatocyte and non-hepatocyte derived cancers in vitro, driving more aggressive tumor behavior in vivo. +transcription factor target 34006907 hsa-mir-503 Hematologic Neoplasms Here we show that inhibition of miRNAs -503 and -23a, alone or in combination, enhances tumor proliferation in hepatocyte and non-hepatocyte derived cancers in vitro, driving more aggressive tumor behavior in vivo. +other 34006268 hsa-mir-1275 Diabetes Mellitus, Type 1 Two miRNAs (hsa-miR-181a and hsa-miR-1275) were screened as T1DM-related miRNAs to build the T1DM-related ceRNA regulatory network, in which genes were considerably enriched in seven pathways. +other 34006268 hsa-mir-181a Diabetes Mellitus, Type 1 Two miRNAs (hsa-miR-181a and hsa-miR-1275) were screened as T1DM-related miRNAs to build the T1DM-related ceRNA regulatory network, in which genes were considerably enriched in seven pathways. +genetics_knock down_promote 34006084 hsa-mir-1266 Carcinoma, Hepatocellular 5p knockdown significantly inhibited the proliferation, migration and invasion of HCC cells. +circulation_biomarker_diagnosis_up 34004247 hsa-mir-150 Sepsis In human, the serum level of miR-150 was down-regulated in septic patients and elevated in non-septic trauma patients compared to healthy controls. +circulation_biomarker_diagnosis_up 34004232 hsa-mir-486 COVID-19 Interestingly, another research group recently reported miR3p is upregulated in blood samples from severe COVID-19 patients who suffer from bradycardia. +circulation_biomarker_diagnosis_up 34004232 hsa-mir-486 Bradycardia Interestingly, another research group recently reported miR3p is upregulated in blood samples from severe COVID-19 patients who suffer from bradycardia. +genetics_knock down_suppress 34004029 hsa-mir-433 Bone Diseases Local delivery of miR3p inhibitor could present a strategy for the management of bone loss disorders and bone defect repair. +other 34003899 hsa-mir-23a Cataract RESULTS: The expression levels of let-7g-5p, miR-23a-3p, miR-23b-3p, and miR-125a-5p were significantly upregulated in patients with senile cataract when compared with those in the control group (P < 0.05). +other 34003899 hsa-mir-125a Cataract RESULTS: The expression levels of let-7g-5p, miR-23a-3p, miR-23b-3p, and miR-125a-5p were significantly upregulated in patients with senile cataract when compared with those in the control group (P < 0.05). +other 34003899 hsa-let-7d Cataract Let-7a-5p, let-7d-5p, let-7g-5p and mir-23b-3p had significant difference in expression between nuclear and anterior subcapsular cataracts. +other 34003899 hsa-let-7a Cataract Let-7a-5p, let-7d-5p, let-7g-5p and mir-23b-3p had significant difference in expression between nuclear and anterior subcapsular cataracts. +other 34003899 hsa-mir-23b Cataract RESULTS: The expression levels of let-7g-5p, miR-23a-3p, miR-23b-3p, and miR-125a-5p were significantly upregulated in patients with senile cataract when compared with those in the control group (P < 0.05). Let-7a-5p, let-7d-5p, let-7g-5p and mir-23b-3p had significant difference in expression between nuclear and anterior subcapsular cataracts. +other 34003899 hsa-let-7g Cataract RESULTS: The expression levels of let-7g-5p, miR-23a-3p, miR-23b-3p, and miR-125a-5p were significantly upregulated in patients with senile cataract when compared with those in the control group (P < 0.05). Let-7a-5p, let-7d-5p, let-7g-5p and mir-23b-3p had significant difference in expression between nuclear and anterior subcapsular cataracts. +transcription factor target 34003896 hsa-mir-19a Macular Degeneration Our objective was to identify potential functional roles of these upregulated miRNAs (miR-19a, miR-126, and miR-410) in AMD, using computational tools for miRNAs prediction and identification, and to demonstrate the miRNAs target genes and signaling pathways. CONCLUSIONS: miR-19a, miR-126, miR-410 and their target genes had a significant correlation with AMD pathogenesis. +transcription factor target 34003896 hsa-mir-126 Macular Degeneration Our objective was to identify potential functional roles of these upregulated miRNAs (miR-19a, miR-126, and miR-410) in AMD, using computational tools for miRNAs prediction and identification, and to demonstrate the miRNAs target genes and signaling pathways. CONCLUSIONS: miR-19a, miR-126, miR-410 and their target genes had a significant correlation with AMD pathogenesis. +transcription factor target 34003896 hsa-mir-410 Macular Degeneration Our objective was to identify potential functional roles of these upregulated miRNAs (miR-19a, miR-126, and miR-410) in AMD, using computational tools for miRNAs prediction and identification, and to demonstrate the miRNAs target genes and signaling pathways. CONCLUSIONS: miR-19a, miR-126, miR-410 and their target genes had a significant correlation with AMD pathogenesis. +lncRNA target 34003875 hsa-mir-510 Squamous Cell Carcinoma of Head and Neck The results indicated there was a high expression of LINC00958 in ESCC, which promoted proliferation, migration, invasion and Epithelial-Mesenchymal Transition (EMT) of ESCC cells, and this effect may be via regulating miR5p. +lncRNA target 34003551 hsa-mir-522 Colonic Neoplasms Taken together, our study confirmed that BVES-AS1 inhibited COAD progression via interacting with miR3p and TAF15 to regulate BVES expression, which might offer a perspective for COAD treatment. +lncRNA target 34003544 hsa-mir-199a Breast Neoplasms These results support a regulatory axis consisting of HIF-1, SNHG1, miR-199a-3p, and TFAM during BC development and metastasis under hypoxic conditions, providing an opportunity to develop targeted therapeutics for BC. +genetics_overexpression_promote 34003510 hsa-mir-497 Squamous Cell Carcinoma of Head and Neck Also, LncRNA FGD5-AS1 overexpression increased cisplatin-resistance in LSCC by modulating the miR +circulation_biomarker_diagnosis_ns 34003488 hsa-mir-146a Lupus Erythematosus, Systemic This study aimed to evaluate the presence of miR-126 and miR-146a in plasma MPs of patients with SLE (SLE MPs) and analyse the ability of MPs to modulate some events in the promonocytic U937 cell line. SLE MPs contained decreased levels of miR-146a, but the miR-126 content in aSLE MPs was increased. +lncRNA target 34002676 hsa-mir-122 Cardiomyopathies 5p may mitigate sepsis-triggered myocardial injury through inhibiting inflammation, oxidative stress and apoptosis via targeting GIT1, which provides a possible therapeutic target for sepsis. +transcription factor target 34002673 hsa-mir-429 Pre-Eclampsia In addition, targeting miR-429 might treat PE. +circRNA target 34002672 hsa-mir-140 Carcinoma, Hepatocellular Mechanistically, circ_0008274 upregulates GRN expressions via adsorbing miR +other 34002670 hsa-mir-490 Stomach Neoplasms In conclusion, lncRNA AL139002.1 was highly expressed in GC cells, and lncRNA AL139002.1/miR3p/HAVCR1 functioned critically in GC by regulating MEK/ERK signaling. +circulation_biomarker_diagnosis_ns 34002665 hsa-mir-146a Asthma In this work, we proved that miR-146a-5p expression was inhibited in asthma patients' plasma and platelet activating factor (PAF)-induced human small airway epithelial cells (HSAECs). +genetics_overexpression_promote 34002647 hsa-mir-24 Esophageal Squamous Cell Carcinoma Additionally, overexpressed miR +transcription factor target 34002613 hsa-mir-1266 Atrial Fibrillation It may be that miR-1266 is an antiarrhythmic miRNA and an AF intervention target in the future (Tab. +lncRNA target 34002487 hsa-mir-101 Carcinoma, Non-Small-Cell Lung Our data indicated that SNHG12 targeted and negatively regulated miR +lncRNA target 34002485 hsa-mir-140 Ovarian Neoplasms H19 upregulated Wnt1 expression through targeting miR-140 in OC cells. +genetics_overexpression_suppress 34002462 hsa-mir-10a Carcinoma, Hepatocellular In particular, the overexpression of SKA1 reversed the inhibitory effects of miR-10a-5p in HCC. +other 34002325 hsa-mir-452 Enterovirus Infections The results suggested that miR-18a and miR-452 repress the reproduction of EV71 virus by binding to VP3. Moreover, EV71 infection also affected the expression of endogenous miR-18a and miR-452. +other 34002325 hsa-mir-18a Enterovirus Infections The results suggested that miR-18a and miR-452 repress the reproduction of EV71 virus by binding to VP3. Moreover, EV71 infection also affected the expression of endogenous miR-18a and miR-452. +other 34001972 hsa-mir-375 Neuroendocrine Tumors Here, we identified and elucidated the function of a miR-375/yes-associated protein (YAP) axis in lung carcinoid (H727) cells. Taken together, we provide compelling evidence that a miR-375/YAP axis is a critical mediator of neuroendocrine differentiation and tumorigenesis in lung carcinoid cells. +lncRNA target 34001919 hsa-mir-24 Nervous System Diseases Characterisation of microRNAs that produce an effect on neurological activity, such as miR-324, and identification of the pathways they regulate will allow a better understanding of the processes involved in normal neurological function and in turn may present novel pharmaceutical targets in treating neurological disease. +lncRNA target 34001703 hsa-mir-138 Carcinoma, Renal Cell Curcumin suppressed renal carcinoma tumorigenesis in vitro and in vivo via regulating circ-FNDC3B/miR +other 34001212 hsa-mir-124 Asthma Expression of miR-124, miR-133b, and miR-130a was down-regulated in asthma patients as compared to controls (p < 0.0001). Up-regulation of miR-125b together with decreased expression of miR-124, miR-133b, and miR-130a may suggest that this miRNA profile is useful for diagnosis and discrimination of clinical phenotypes of asthma. +other 34001212 hsa-mir-133b Asthma Expression of miR-124, miR-133b, and miR-130a was down-regulated in asthma patients as compared to controls (p < 0.0001). Up-regulation of miR-125b together with decreased expression of miR-124, miR-133b, and miR-130a may suggest that this miRNA profile is useful for diagnosis and discrimination of clinical phenotypes of asthma. +other 34001212 hsa-mir-130a Asthma Expression of miR-124, miR-133b, and miR-130a was down-regulated in asthma patients as compared to controls (p < 0.0001). Up-regulation of miR-125b together with decreased expression of miR-124, miR-133b, and miR-130a may suggest that this miRNA profile is useful for diagnosis and discrimination of clinical phenotypes of asthma. +genetics_overexpression_promote 34001147 hsa-mir-129 Carcinoma, Renal Cell Overexpressed miR +circRNA target 34001137 hsa-mir-137 Stomach Neoplasms Moreover, PBX3, a target of miR-137, play a DB-resistant role in GC cells. +genetics_overexpression_suppress 34001135 hsa-mir-139 Glioma 5p overexpression inhibited cell proliferation, migration, and invasion of glioma in vitro. +genetics_overexpression_suppress 34000513 hsa-mir-184 Breast Neoplasms It was also found miR-184 expression was high in the BC cell lines treated with tripterine and that miR-184 overexpression reduced the viability, proliferation, and invasion abilities of BC cells under tripterine treatment. +exosome 34000376 hsa-mir-155 Intervertebral Disc Degeneration BMSC exosomes increase miR-155 expression in NPCs, which targets Bach1 and in turn upregulates HO-1 expression, activates autophagy in NPCs, inhibits the apoptosis level, and improves intervertebral disc degeneration. +transcription factor target 34000275 hsa-mir-494 Macular Degeneration MiR494-3p may be a candidate molecular target of diagnosis and therapy for age-related macular degeneration. +circulation_biomarker_diagnosis_up 33999859 hsa-mir-103a Carcinoma, Non-Small-Cell Lung Pumilio2 (Pum2) bound with miR-103a-3p in cytoplasm and nucleus, and facilitated packaging into CAF-derived exosomes in NSCLC cells. +lncRNA target 33999777 hsa-mir-155 Thyroid Carcinoma, Anaplastic Our research proved that AFAP-AS1 could facilitate progression of thyroid cancer sponging miR5p through ETS1/ERK pathway. +lncRNA target 33999393 hsa-mir-223 Myocardial Infarction 3p may downregulate PIK3C2A expression, resulting in the inhibition of myocardial cell apoptosis in rats with myocardial infarction via the activation of PI3K/Akt signaling pathway. +other 33999360 hsa-mir-3156 Breast Neoplasms Collectively, TPT1-AS1 diminished cell proliferation and sensitized cells to chemotherapy by sponging miR5p and upregulating CASP2, acting as a biomarker for patients with breast cancer. +genetics_knock down_promote 33999341 hsa-mir-135b Neurotic Disorders The results indicated that the miR-135b-5p inhibitor significantly increased the weight loss induced by CUMS compared with the model group, while reducing the expression levels of miR-135b-5p and further alleviating the depression-like behavior induced by CUMS. +genetics_knock down_promote 33999341 hsa-mir-135b Campomelia Cumming type The results indicated that the miR-135b-5p inhibitor significantly increased the weight loss induced by CUMS compared with the model group, while reducing the expression levels of miR-135b-5p and further alleviating the depression-like behavior induced by CUMS. +genetics_knock down_promote 33999341 hsa-mir-135b Depressive Disorder The results indicated that the miR-135b-5p inhibitor significantly increased the weight loss induced by CUMS compared with the model group, while reducing the expression levels of miR-135b-5p and further alleviating the depression-like behavior induced by CUMS. +other 33999095 hsa-mir-146 Epidural Fibrosis The upregulation of miR-146 enhanced the fibroblasts proliferation and inflammatory response in epidural fibrosis. +circulation_biomarker_diagnosis_ns 33997822 hsa-mir-375 Teratoma Our results confirm prior reports that serum miR-375 cannot predict teratoma, and suggest that there may not exist a predictive serum miRNA for teratoma. +other 33997317 hsa-mir-21 Diabetic Foot A previous report showed that NFkappaB-miR-21 pathway could serve as an innovative alternative to devise therapeutics for healing diabetic ulcers. +therapeutic target 33997273 hsa-mir-499 Lung Neoplasms MicroRNA-499 serves as a sensitizer for lung cancer cells to radiotherapy by inhibition of CK2α-mediated phosphorylation of p65. +genetics_overexpression_promote 33997050 hsa-mir-942 Colorectal Neoplasms 5p overexpression. +circulation_biomarker_diagnosis_ns 33997016 hsa-mir-146a Myasthenia Gravis OBJECTIVE: To investigate the expression and clinical significance of miR-146a and tumor necrosis factor receptor-associated factor 6 (TRAF6) in myasthenia gravis (MG) patient serum. +other 33997006 hsa-mir-373 Hypoxia-Ischemia, Brain In the occurrence and development of HIE, miRNA-373 is positively correlated with HIF-1alpha, MMP-9, and VEGF. +other 33996940 hsa-mir-146b Cardiotoxicity Differential expression analysis of miRNAs profiling identified mir-146b to be up-regulatein (FC = 14, p = 0.046) in patients with CVAE. +other 33996940 hsa-mir-146b Multiple Myeloma Differential expression analysis of miRNAs profiling identified mir-146b to be up-regulatein (FC = 14, p = 0.046) in patients with CVAE. +lncRNA target 33996578 hsa-mir-212 Carcinoma, Non-Small-Cell Lung In addition, ILF3-AS1 negatively controlled miR-212, which in turn targeted SMAD1 expression, thereby regulating NSCLC cell viability and apoptosis. +other 33996574 hsa-mir-139 Pancreatic Neoplasms Baicalein Induces Apoptosis of Pancreatic Cancer Cells by Regulating the Expression of miR-139-3p and miR-196b-5p. +other 33996574 hsa-mir-196b Pancreatic Neoplasms Baicalein Induces Apoptosis of Pancreatic Cancer Cells by Regulating the Expression of miR-139-3p and miR-196b-5p. +target gene 33996559 hsa-mir-138 Breast Neoplasms LINC00467 promotes progression of breast cancer through interacting with miR-138-5p and LIN28B directly +target gene 33996547 hsa-mir-326 Stomach Neoplasms circATP2B1 Promotes Aerobic Glycolysis in Gastric Cancer Cells Through Regulation of the miR-326 Gene Cluster. +lncRNA target 33996428 hsa-mir-198 Osteosarcoma CONCLUSION: Circ_0010220 contributes to osteosarcoma progression through mediating miR-198/STX6 axis, which might be a novel therapeutic target for osteosarcoma therapy. +circRNA target 33996257 hsa-mir-149 Thyroid Cancer, Papillary Overall, our study pinpoints the oncogenic role of TR4 in PTC development, and the targeting of TR4/circ-FLNA/miR +lncRNA target 33996254 hsa-mir-429 Fatty Liver dependent inhibition of PPARalpha, leading to cholesterol accumulation in liver and the occurrence of fatty liver. +exosome 33995992 hsa-mir-21 Arthritis, Rheumatoid Collectively, BMSCs-derived EVs relieved RA by delivering miR-21, while the exosomal miR-21 alleviated RA through targeting the TET1/KLF4 regulatory axis. +lncRNA target 33995991 hsa-mir-144 Arthritis, Rheumatoid 3p/ROCK2/WNT in RA was investigated as a potential target for RA therapy. +other 33995948 hsa-mir-126 Asthma c-kit+ cells had the potential to diminish asthma-related pathologies presumably by controlling the transcription of miRNA-126 and -133. +other 33995948 hsa-mir-133 Asthma c-kit+ cells had the potential to diminish asthma-related pathologies presumably by controlling the transcription of miRNA-126 and -133. +lncRNA target 33995660 hsa-mir-138 Myocardial Infarction, Acute Conclusions: Our findings suggest that M2M-derived circUbe3a-containing SEVs promote the proliferation, migration, and phenotypic transformation of CFs by directly targeting the miR5p/RhoC axis, which may also exacerbate myocardial fibrosis after acute myocardial infarction. +target gene 33995647 hsa-mir-146b Pancreatic Neoplasms MiR-146b-3p regulates proliferation of pancreatic cancer cells with stem cell-like properties by targeting MAP3K10. +other 33995620 hsa-mir-663 Carcinoma, Hepatocellular In summary, acidic pH(e) enhances anoikis resistance of HCC cells by inducing autophagy, which is regulated by miR3p. +other 33995497 hsa-mir-6512 Non-alcoholic Fatty Liver Disease Conclusion: The crosstalk of hsa_circ_0000313-hsa-miR3p-PEG10 and some related non-coding RNAs may take part in NAFLD's pathogenesis, which could be the potential biomarkers of NAFLD in the future. +other 33995494 hsa-mir-1 Familial Primary Pulmonary Hypertension 3p could regulate gene expression in IPAH. +lncRNA target 33995003 hsa-mir-186 Femur Head Necrosis Inhibition of miR-186 reversed the protection of Ato on SANFH rats, while inhibition of TLR4 restored the protective effect of Ato. +lncRNA target 33994849 hsa-mir-218 Stomach Neoplasms Negatively modulated by YY1, SNHG12 promotes GC metastasis and EMT by regulating the miR5p/YWHAZ axis and stabilizing CTNNB1 via activation of the beta-catenin signaling pathway. +genetics_knock down_suppress 33994812 hsa-mir-128 Glioma Furthermore, the effects of HCP5 knockdown on radiosensitivity of glioma cells were attenuated by the inhibitor of miR-128. +exosome 33994542 hsa-mir-4717 Lymphoma Our results suggest that exosomes including miR5p secreted from CAFs play a pivotal role in the lymphoma microenvironment, indicating that they are a promising therapeutic target. +genetics_knock down_promote 33994521 hsa-mir-99a Glioma Furthermore, miR-99a was involved in the circGFRA1-regulated glioma cell behaviors. In conclusion, our study demonstrated that knockdown circGFRA1 inhibits glioma cell proliferation and migration by upregulating microRNA-99a. +lncRNA target 33994508 hsa-mir-518a Myocardial Infarction More importantly, the miR-518a-5p mimic enhanced cell proliferation and repressed apoptosis of H/R-injured HUVEC cells by inhibiting GZMB expression.We proved that miR-518a-5p could partly attenuate H/R-induced HUVEC cell injury by targeting GZMB, and perhaps the miR-518a-5p/GZMB axis could be potential therapeutic targets for myocardial infarction. +circulation_biomarker_diagnosis_ns 33994501 hsa-mir-210 Sepsis The above cellular and molecular alterations in H9C2 cells induced by septic serum were enhanced by miR +circulation_biomarker_diagnosis_ns 33994501 hsa-mir-210 Cardiomyopathies The above cellular and molecular alterations in H9C2 cells induced by septic serum were enhanced by miR +transcription factor target 33994349 hsa-mir-139 Staphylococcal Infections aureus-infected wound healing, suggesting that JTXK or other miR5p suppressants may be effective for treating infected skin wounds. +other 33994260 hsa-mir-125b psoriasis 1 Moreover, the expression of miR-125b could be substantially decreased within psoriasis lesion tissue samples, while miR-125b could negatively regulate the SH3PXD2A-AS1 and STAT3 expression. A novel STAT3 related mechanism whereby STAT 3/ SH3PXD2A-AS1/ miR-125b/STAT3 positive feedback loop which could potentially affect the pathogenesis of Psoriasis has been established. +lncRNA target 33993846 hsa-mir-128 Stomach Neoplasms HCP5 aggravated the resistance of GC cells to DDP in vitro by elevating HMGA2 expression via sponging miR-128. +genetics_GWAS 33993456 hsa-mir-216b Glaucoma Targeting the epigenetic axis of LINC01518/hsa-miR-216b-5p may provide new insight into the pathological development of human glaucoma. +lncRNA target 33993382 hsa-mir-662 Pancreatic Carcinoma CONCLUSIONS: This study sheds light on miRNA-3662 inhibits PDAC cell chemoresistance and aerobic glycolysis through a negative feedback loop with HIF-1a. +lncRNA target 33993369 hsa-mir-183 Glioma 5p targeted TUSC2 and miR +transcription factor target 33993322 hsa-mir-217 Prostatic Neoplasms 5p inhibited the expression of EMT-related proteins by regulating the expression of the target gene CLU, and further inhibited the invasion and migration of prostate cancer cells. +lncRNA target 33993193 hsa-mir-16 Stomach Neoplasms Our research indicates that LINC00473/miR5p/CCND2 axis plays a role in the proliferation of GC and modulates AQP3 to influence GC cell metastasis, making it a potential therapeutic target for GC. +lncRNA target 33993032 hsa-mir-155 Abortion, Habitual In conclusion, the miRNA5p can not only promote the growth and proliferation but also inhibit the apoptosis of decidua stromal cells depending on inhibiting NF-kappaB signaling pathway in recurrent miscarriage. +other 33992764 hsa-mir-20a Hepatitis B, Chronic Finally, miR5p was positively correlated with titer of hepatitis B virus DNA (r = 0.438, P = 0.008) and hepatitis B e antigen (r = 0.610, P < 0.001), and miR-320a-3p was negatively correlated with hepatitis B virus DNA titer (r = -0.366, P = 0.028) at baseline. +other 33992764 hsa-mir-122 Hepatitis B, Chronic Finally, miR5p was positively correlated with titer of hepatitis B virus DNA (r = 0.438, P = 0.008) and hepatitis B e antigen (r = 0.610, P < 0.001), and miR-320a-3p was negatively correlated with hepatitis B virus DNA titer (r = -0.366, P = 0.028) at baseline. +genetics_knock down_promote 33992709 hsa-mir-15a Glioma CONCLUSION: LINC00511 knockdown inhibits glioma cell progression via miR-15a-5p/AEBP1 axis. +genetics_overexpression_promote 33992597 hsa-mir-761 Colorectal Neoplasms CircMYH9 overexpression protected CRC cells from Baicalin-induced injury partly through down-regulating miR-761. +other 33992122 hsa-mir-212 Osteochondrodysplasias 3p were a differentially high expression in normo-androgenic PCOS patients than NOR patients. +other 33992122 hsa-mir-7 Osteochondrodysplasias 3p were a differentially high expression in normo-androgenic PCOS patients than NOR patients. +other 33992122 hsa-mir-212 Norrie disease 3p were a differentially high expression in normo-androgenic PCOS patients than NOR patients. +other 33992122 hsa-mir-378 Osteochondrodysplasias 3p were a differentially high expression in normo-androgenic PCOS patients than NOR patients. +other 33992122 hsa-mir-20a Norrie disease Our results showed that miRNA-320a was significantly different in top-quality embryos versus non-top-quality embryos on day 3 in NOR patients with a sensitivity of 80% and specificity of 71%, (AUC=[0.753 (0.651; 0.855)], p=0.001). +other 33992122 hsa-mir-224 Osteochondrodysplasias 3p were a differentially high expression in normo-androgenic PCOS patients than NOR patients. +other 33992122 hsa-mir-212 Polycystic Ovary Syndrome 3p were a differentially high expression in normo-androgenic PCOS patients than NOR patients. +other 33992122 hsa-mir-7 Polycystic Ovary Syndrome 3p were a differentially high expression in normo-androgenic PCOS patients than NOR patients. +other 33992122 hsa-mir-224 Norrie disease 3p were a differentially high expression in normo-androgenic PCOS patients than NOR patients. +other 33992122 hsa-mir-7 Norrie disease 3p were a differentially high expression in normo-androgenic PCOS patients than NOR patients. +other 33992122 hsa-mir-224 Polycystic Ovary Syndrome 3p were a differentially high expression in normo-androgenic PCOS patients than NOR patients. +other 33992122 hsa-mir-378 Polycystic Ovary Syndrome 3p were a differentially high expression in normo-androgenic PCOS patients than NOR patients. +other 33992122 hsa-mir-378 Norrie disease 3p were a differentially high expression in normo-androgenic PCOS patients than NOR patients. +lncRNA target 33991848 hsa-mir-139 Glioblastoma CONCLUSIONS: Our study supports a tumorigenic role for RP3-439F8.1 in GBM through the RP3-439F8.1/miR +genetics_overexpression_promote 33991762 hsa-mir-128 Carcinoma, Hepatocellular And the effects of overexpressed CDC6 on inhibiting E-Cadherin expression yet promoting MMP2, MMP9, N-Cadherin and Vimentin expressions in HCC cells were reversed by up-regulating miR +lncRNA target 33991434 hsa-mir-143 Bone Diseases The lncRNA AC092155/miR3p/STMN1 axis may be a new therapeutic target for bone-related diseases. +genetics_GWAS 33991356 hsa-mir-7 Parkinson Disease miR-7 and miR-30, implied in the pathogenesis of PD and in the post-transcriptional control of alpha-synuclein and NLRP3 expression, were also increased in PD. CONCLUSIONS: Mononuclear cells of newly diagnosed PD subjects display a hyper-expression of the P2X7R/NLRP3 inflammasome platform that seems to modulate cellular alpha-synuclein content and is reduced after PD treatment; an impaired JNK phosphorylation might be the intracellular signalling mediating this effect, undergoing an epigenetic regulation by miR-7 and miR-30. +transcription factor target 33990905 hsa-mir-519d high grade glioma Other genes such as MIR519D and NOP53 are also discovered as tumor suppressor genes in gliomas which are located on 19q13.3 and 19q13.4, respectively. +other 33990872 hsa-mir-4417 Prostatic Neoplasms, Castration-Resistant Upregulation of miR-3195, miR-3687 and miR-4417 is associated with castration-resistant prostate cancer. RESULTS In our profiling study, several miRNAs were found to be deregulated in CRPC compared to primary PCa tissue, of which miR-205 (- 4.5-fold; p=0.0009), miR-92b (- 3.1 fold; p<0.0001) were downregulated and miR-3195 (5.6-fold; p<0.0001), miR-3687 (8.7-fold; p=0.0006) and miR-4417 (5.0-fold; p=0.0005) were most upregulated. +other 33990872 hsa-mir-195 Prostatic Neoplasms, Castration-Resistant Upregulation of miR-3195, miR-3687 and miR-4417 is associated with castration-resistant prostate cancer. RESULTS In our profiling study, several miRNAs were found to be deregulated in CRPC compared to primary PCa tissue, of which miR-205 (- 4.5-fold; p=0.0009), miR-92b (- 3.1 fold; p<0.0001) were downregulated and miR-3195 (5.6-fold; p<0.0001), miR-3687 (8.7-fold; p=0.0006) and miR-4417 (5.0-fold; p=0.0005) were most upregulated. +other 33990872 hsa-mir-3687 Prostatic Neoplasms, Castration-Resistant Upregulation of miR-3195, miR-3687 and miR-4417 is associated with castration-resistant prostate cancer. RESULTS In our profiling study, several miRNAs were found to be deregulated in CRPC compared to primary PCa tissue, of which miR-205 (- 4.5-fold; p=0.0009), miR-92b (- 3.1 fold; p<0.0001) were downregulated and miR-3195 (5.6-fold; p<0.0001), miR-3687 (8.7-fold; p=0.0006) and miR-4417 (5.0-fold; p=0.0005) were most upregulated. +other 33990872 hsa-mir-205 Prostatic Neoplasms, Castration-Resistant RESULTS In our profiling study, several miRNAs were found to be deregulated in CRPC compared to primary PCa tissue, of which miR-205 (- 4.5-fold; p=0.0009), miR-92b (- 3.1 fold; p<0.0001) were downregulated and miR-3195 (5.6-fold; p<0.0001), miR-3687 (8.7-fold; p=0.0006) and miR-4417 (5.0-fold; p=0.0005) were most upregulated. +other 33990872 hsa-mir-92b Prostatic Neoplasms, Castration-Resistant RESULTS In our profiling study, several miRNAs were found to be deregulated in CRPC compared to primary PCa tissue, of which miR-205 (- 4.5-fold; p=0.0009), miR-92b (- 3.1 fold; p<0.0001) were downregulated and miR-3195 (5.6-fold; p<0.0001), miR-3687 (8.7-fold; p=0.0006) and miR-4417 (5.0-fold; p=0.0005) were most upregulated. +other 33990669 hsa-mir-210 Melanoma Based on the results of measurements of mitochondrial resipiratory activity, ROS production, and changes in the metabolites obtained in cells under the observed conditions, we concluded that silencing of HIF-1alpha and miR-210 yields apoptosis and, ultimately, apoptotic cell death in A375 melanoma cells. +lncRNA target 33990639 hsa-mir-34a Uterine Cervical Neoplasms 5p) and three tumor suppressors (miR-34a, miR-145, and miR-218) as selected by database search in cervical pre-cancer, cancer, and normal controls including cervical cancer cell lines were analyzed using qRT-PCR. +lncRNA target 33990639 hsa-mir-21 Uterine Cervical Neoplasms 5p) and three tumor suppressors (miR-34a, miR-145, and miR-218) as selected by database search in cervical pre-cancer, cancer, and normal controls including cervical cancer cell lines were analyzed using qRT-PCR. +circulation_biomarker_diagnosis_ns 33990639 hsa-mir-145 Uterine Cervical Neoplasms 5p, and miR-34a-5p in urine yielded 100% sensitivity and 92.8% specificity in distinguishing precancer and cancer patients from healthy controls and it well correlates with those of serum and tumor tissues. +lncRNA target 33990639 hsa-mir-218 Uterine Cervical Neoplasms 5p) and three tumor suppressors (miR-34a, miR-145, and miR-218) as selected by database search in cervical pre-cancer, cancer, and normal controls including cervical cancer cell lines were analyzed using qRT-PCR. +genetics_knock down_promote 33990540 hsa-mir-135b Carcinoma, Non-Small-Cell Lung Overexpressing miR-135b significantly promoted the aggressiveness of NSCLC, as evidenced by enhanced cell proliferation, migration, invasion, anti-apoptosis, and angiogenesis in vitro and in vivo, and knockdown of miR-135b had the opposite effects. +circRNA target 33990513 hsa-mir-149 Angelman Syndrome Circ_CHFR promoted the proliferation, invasion, and migration of PDGF-BB-induced HVSMCs through miR5p/NRP2 axis, providing a new insight into the pathogenesis of AS and a potential therapeutic target for AS treatment. +lncRNA target 33990028 hsa-mir-210 Pre-Eclampsia MicroRNA-210 (miR-210) can decrease trophoblast cell migration and invasion and may act as a biomarker for preeclampsia. LncRNA maternally expressed gene 3 (MEG3) plays a positive role in pre-eclampsia, and MEG3 can be a downstream target of miR-210 in human umbilical vein endothelial cells (HUVEC). +lncRNA target 33989902 hsa-mir-574 Breast Neoplasms Together, MAFG-AS1 acts as an oncogene via regulation of miR5p/SOD2 axis in BC cells. +other 33989778 hsa-mir-7 Diabetes Mellitus CONCLUSIONS: Our study indicates that miRmediated beta-cell dedifferentiation induces EMT signalling and a chronic response to tissue injury, which alters the islet microenvironment and predisposes to fibrosis. +genetics_overexpression_promote 33989616 hsa-mir-1224 Anodontia H9C2 cells under H/R conditions displayed increased synthesis of ROS, along with overexpression of miR-1224 and downregulation of GPX4. +other 33988168 hsa-mir-155 Breast Neoplasms This study has been conducted to investigate miR 21, miR 27b, miR 125a, miR 155, miR 200c, miR 335 miR373 as biomarkers in the early diagnosis of breast cancer; a selection based on the literature. As a result, the quantities of miR 21, miR155 and miR125 were significantly higher in the breast cancer group than in healthy controls. +other 33988168 hsa-mir-125 Breast Neoplasms This study has been conducted to investigate miR 21, miR 27b, miR 125a, miR 155, miR 200c, miR 335 miR373 as biomarkers in the early diagnosis of breast cancer; a selection based on the literature. As a result, the quantities of miR 21, miR155 and miR125 were significantly higher in the breast cancer group than in healthy controls. +other 33988168 hsa-mir-21 Breast Neoplasms This study has been conducted to investigate miR 21, miR 27b, miR 125a, miR 155, miR 200c, miR 335 miR373 as biomarkers in the early diagnosis of breast cancer; a selection based on the literature. As a result, the quantities of miR 21, miR155 and miR125 were significantly higher in the breast cancer group than in healthy controls. +lncRNA target 33988127 hsa-mir-350 Myocardial Reperfusion Injury These findings suggest lncRNA AK020546 protects against ischemia/reperfusion and oxidative stress injury by sequestering miR3p and activating ErbB3, which highlights its potential as a therapeutic target for ischemic heart diseases. +genetics_overexpression_promote 33988065 hsa-mir-425 Retinoblastoma Additionally, circMKLN1 overexpression hampered tumor growth in vivo.Conclusions: CircMKLN1 overexpression decelerated the progression of RB through sponging miR +other 33987861 hsa-mir-21 Osteosarcoma "This research work has introduced an identification of an osteosarcoma biomarker ""miRNA-21"" on the interdigitated electrochemical sensor by nuclease digestion. This nuclease digestion technique with miRNA-21 identification helps in detecting osteosarcoma and related issues." +lncRNA target 33987822 hsa-mir-199a Endometriosis These findings suggest that hsa-miR-199a-3p may act as a tumor suppressor in endometriosis development. +lncRNA target 33987822 hsa-mir-199a Autoimmune Lymphoproliferative Syndrome Transfection of hsa-miR-199a-3p inhibited the migration, invasion, and contractility of ECSCs via inhibition of PAK4 mRNA expression. +target gene 33987474 hsa-mir-542 Neuroblastoma MiR-542-3p Suppresses Neuroblastoma Cell Proliferation and Invasion by Downregulation of KDM1A and ZNF346. +target gene 33987473 hsa-mir-326 Lung Neoplasms Sevoflurane Inhibits Proliferation, Invasion, but Enhances Apoptosis of Lung Cancer Cells by Wnt/β-catenin Signaling via Regulating lncRNA PCAT6/miR-326 Axis. +other 33987373 hsa-mir-1261 Carcinoma, Hepatocellular Additionally, luciferase assays and RNA immunoprecipitation (RIP) assays were used to explore the interactions of circ0097009, microRNA-1261 (miR-1261), and solute carrier family 7 member 11 (SLC7A11) in HCC. CONCLUSIONS: Circ0097009 acts as a competing endogenous RNA to regulate the expression of SLC7A11, a key regulator of cancer cell ferroptosis, by sponging miR-1261 in HCC. +other 33987373 hsa-mir-1261 Thyroid Cancer, Papillary Additionally, luciferase assays and RNA immunoprecipitation (RIP) assays were used to explore the interactions of circ0097009, microRNA-1261 (miR-1261), and solute carrier family 7 member 11 (SLC7A11) in HCC. CONCLUSIONS: Circ0097009 acts as a competing endogenous RNA to regulate the expression of SLC7A11, a key regulator of cancer cell ferroptosis, by sponging miR-1261 in HCC. +genetics_overexpression_suppress 33987352 hsa-mir-194 Myocardial Reperfusion Injury CONCLUSIONS: Our study shows overexpression of miR +virus_miRNA 33987336 hcmv-mir-US5-1 adverse pregnancy outcomes plasma concentrations of hcmv-miR-UL148D, hcmv-miR-US25-1-5p and hcmv-miR-US5-1 were significantly increased in pregnant women with APOs compared with normal controls. +virus_miRNA 33987336 hcmv-mir-UL148D adverse pregnancy outcomes plasma concentrations of hcmv-miR-UL148D, hcmv-miR-US25-1-5p and hcmv-miR-US5-1 were significantly increased in pregnant women with APOs compared with normal controls. +virus_miRNA 33987336 hcmv-mir-US25-1 adverse pregnancy outcomes plasma concentrations of hcmv-miR-UL148D, hcmv-miR-US25-1-5p and hcmv-miR-US5-1 were significantly increased in pregnant women with APOs compared with normal controls. +target gene 33987194 hsa-mir-3 Breast Neoplasms hsa-miR-33-5p as a Therapeutic Target Promotes Apoptosis of Breast Cancer Cells via Selenoprotein T. +circulation_biomarker_prognosis_up 33987186 hsa-mir-107 Lymphoma, Large B-Cell, Diffuse 3p were detected in the plasma of DLBCL patients and showed potential diagnostic value. +lncRNA target 33987098 hsa-mir-1301 Stomach Neoplasms 3p as a novel potential therapeutic target that is associated with the tumorigenesis and progression of gastric cancer. +other 33987074 hsa-mir-9 Disease 5p activated the SIRT1/NF-kappaB pathway to promote wear-particle-induced osteoclastogenesis. +transcription factor target 33987074 hsa-mir-9 Yaws 5p may be a useful therapeutic target for PIO remission and treatment. +tissue_expression_ns 33986977 hsa-mir-144 Pelizaeus-Merzbacher Disease In the present work, we evaluated the gene expression of miR +lncRNA target 33986977 hsa-mir-381 Pelizaeus-Merzbacher Disease 3p increased throughout the first 24 h of PMI, contrary to miR-23b-3p. +lncRNA target 33986977 hsa-mir-23b Pelizaeus-Merzbacher Disease 3p increased throughout the first 24 h of PMI, contrary to miR-23b-3p. +target gene 33986876 hsa-mir-223 Breast Neoplasms miR-223-3p may promote cell proliferation, migration, invasion and EMT through the Hippo/Yap signaling pathway. +genetics_knock down_promote 33986875 hsa-mir-383 Lymphoma, Large B-Cell, Diffuse 5p knockdown. +genetics_overexpression_promote 33986868 hsa-mir-891a Carcinoma, Non-Small-Cell Lung In addition, the experiments revealed that NSCLC cell proliferation, invasion and migration were significantly increased by the overexpression of miR-891a-5p and were significantly reduced by its downregulation. +genetics_overexpression_promote 33986863 hsa-mir-4417 Uterine Cervical Neoplasms However, overexpression of miR-4417 inhibited CSCC cell invasion and migration, and attenuated the effects of PSMG3-AS1 overexpression in CSCC cells. +circulation_biomarker_diagnosis_ns 33986857 hsa-mir-22 Osteoporosis 3p expression was lower while MAPK14 expression was higher in the serum from patients with OP compared with healthy volunteers. +lncRNA target 33986850 hsa-mir-761 Colorectal Neoplasms A functional study suggested that LINC01535 silencing inhibited CRC cell proliferation and invasion but enhanced cisplatin sensitivity of CRC cells, while co-transfection with a miR-761 inhibitor reversed these biological effects. +lncRNA target 33986849 hsa-mir-499 Myocardial Reperfusion Injury In summary, IPostC protected the rat myocardium against I/R injury, by inhibiting local and systemic complement activation; inflammation; NF-kappaB signaling; and upregulation of miR-499. +target gene 33986848 hsa-mir-660 Liver Neoplasms miR-660 promotes liver cancer cell proliferation by targeting PPP2R2A. +genetics_knock down_suppress 33986844 hsa-mir-107 Carcinoma, Non-Small-Cell Lung HMGB1-knockdown inhibited the proliferation and enhanced the radiosensitivity of NSCLC cells, which may be regulated via miR-107 by mediating the TLR4/NF-kappaB signaling pathway. +circulation_biomarker_diagnosis_ns 33986829 hsa-mir-770 Diabetes Mellitus, Type 2 5p was highly expressed in the serum of patients with T2DM compared with healthy volunteers. +transcription factor target 33986822 hsa-mir-137 Brain Damage, Chronic Electroacupuncture treatment attenuated brain injury in CCH model group via regulating miR-137/NOX4 axis. These results suggest that electroacupuncture therapy for CCH may be mediated by miR-137/NOX4 axis. +lncRNA target 33986803 hsa-mir-28 Lymphoma, Large B-Cell, Diffuse In sum, our findings clearly indicate that TUC338 functions as an oncogenic lncRNA in DLBCL through activating EGFR/PI3K/AKT pathway via sponging and inhibiting miR +target gene 33986801 hsa-mir-1224 Breast Neoplasms miR-1224-3p Promotes Breast Cancer Cell Proliferation and Migration through PGM5-Mediated Aerobic Glycolysis. +genetics_overexpression_suppress 33986660 hsa-mir-497 Retinoblastoma miR-497 inhibitor or WEE1 overexpression dramatically reversed the effects of TRPM2-AS downregulating on the malignant phenotypes of RB cells. +lncRNA target 33986610 hsa-mir-1178 Thyroid Cancer, Papillary CONCLUSION: BRCA2 rs15869 is characterized as a potential biomarker associated with PTC risk, highlighting the contribution of the hsa-miR3p via functional exploration. +other 33986456 hsa-mir-192 Metabolic Diseases Additionally, miRNA 192 was significantly elevated in metabolically unhealthy obesity. +other 33986456 hsa-mir-34a Metabolic Diseases Several miRNA levels including miRNAs 34a, 93, 122, and 192 were statistically significantly differing between individuals with prediabetes, impaired glucose tolerance, metabolic syndrome, or nonalcoholic fatty liver disease compared to the respective controls. +other 33986456 hsa-mir-192 Obesity Additionally, miRNA 192 was significantly elevated in metabolically unhealthy obesity. +other 33986456 hsa-mir-34a Obesity Several miRNA levels including miRNAs 34a, 93, 122, and 192 were statistically significantly differing between individuals with prediabetes, impaired glucose tolerance, metabolic syndrome, or nonalcoholic fatty liver disease compared to the respective controls. +other 33986358 hsa-mir-363 Urinary Bladder Diseases A three urinary miRNA signature (miR-10a-5p, miR-301b-3p and miR3p) could discriminate between controls and patients with LUTD (BLUTD and NLUTD). +other 33986358 hsa-mir-10a Urinary Bladder Diseases A three urinary miRNA signature (miR-10a-5p, miR-301b-3p and miR3p) could discriminate between controls and patients with LUTD (BLUTD and NLUTD). +transcription factor target 33986262 hsa-mir-146a Osteoarthritis Our findings demonstrate, for the first time, that KGN exerts anti-arthritic effects via activation of the miR-146a-NRF2 axis and KGN is a promising heterocyclic molecule to prevent OA-induced cartilage degeneration. +transcription factor target 33986262 hsa-mir-146a Cartilage Diseases Our findings demonstrate, for the first time, that KGN exerts anti-arthritic effects via activation of the miR-146a-NRF2 axis and KGN is a promising heterocyclic molecule to prevent OA-induced cartilage degeneration. +genetics_knock down_promote 33986259 hsa-mir-8055 Cardiomyopathies Knockdown of circACSL1 or overexpression of miR-8055 reduced myocardial inflammation and myocardial injury level and these effects were rescued by overexpression of MAPK14. In summary, our study demonstrated that circACSL1 could aggravate myocardial inflammation and myocardial injury through competitive absorption of miR-8055, thereby upregulating MAPK14 expression. +genetics_knock down_promote 33986259 hsa-mir-8055 Myocarditis Knockdown of circACSL1 or overexpression of miR-8055 reduced myocardial inflammation and myocardial injury level and these effects were rescued by overexpression of MAPK14. In summary, our study demonstrated that circACSL1 could aggravate myocardial inflammation and myocardial injury through competitive absorption of miR-8055, thereby upregulating MAPK14 expression. +other 33985670 hsa-mir-122 Asphyxia In a previous study, four biomarkers-dual-specificity phosphatase 1 (DUSP1), potassium voltage-gated channel subfamily J member 2 (KCNJ2), miR-122, and miRwere screened in human cardiac tissue from cadavers that died from mechanical asphyxia compared with those that died from craniocerebral injury, hemorrhagic shock, or other causes. +other 33985670 hsa-mir-185 Asphyxia In a previous study, four biomarkers-dual-specificity phosphatase 1 (DUSP1), potassium voltage-gated channel subfamily J member 2 (KCNJ2), miR-122, and miRwere screened in human cardiac tissue from cadavers that died from mechanical asphyxia compared with those that died from craniocerebral injury, hemorrhagic shock, or other causes. +lncRNA target 33985638 hsa-mir-29a Fatty Liver MiR-29 a mimic and miR-29 a inhibitor were transfected into hepatocytes, and then established the human steatotic hepatocyte model, the result of oil red O staining and triglyceride(TG)lipid content were observed, the expression of Sirt1 mRNA and protein were detected by qRT-PCR and Western blotting, respectively. +other 33985567 hsa-mir-424 Cardiovascular Diseases 5p-based therapies may be used to reduce CVD morbidity/mortality in T1DM. +other 33985567 hsa-mir-424 Diabetes Mellitus, Type 1 5p-based therapies may be used to reduce CVD morbidity/mortality in T1DM. +epigenetics 33985545 hsa-mir-106b Carcinoma, Hepatocellular Mechanistic analysis revealed that circMEMO1 can modulate the promoter methylation and gene expression of TCF21 to regulate HCC progression by acting as a sponge for miR-106b-5p, which targets the TET family of genes and increases the 5hmC level. +lncRNA target 33985523 hsa-mir-155 Neurogenic Inflammation coli infection induced miR-155 and miR-146a, which collectively regulated bacteria-triggered neuroinflammatory responses through negative feedback regulation involving the TLR-mediated NF-kappaB and EGFR-NF-kappaB signaling pathways, thus protecting the central nervous system from further neuroinflammatory damage. +lncRNA target 33985523 hsa-mir-146a Neurogenic Inflammation coli infection induced miR-155 and miR-146a, which collectively regulated bacteria-triggered neuroinflammatory responses through negative feedback regulation involving the TLR-mediated NF-kappaB and EGFR-NF-kappaB signaling pathways, thus protecting the central nervous system from further neuroinflammatory damage. +genetics_overexpression_promote 33985519 hsa-mir-1303 Leukemia, Myeloid, Acute Furthermore, the effect of TPTEP1 overexpression on AML cell proliferation was counteracted under miR-1303 upregulation. +other 33984967 hsa-mir-92b Small Cell Lung Carcinoma To test the relationship of membrane fluidity and invasiveness, we first demonstrated that transfection of small RNA miR-92b-3p can significantly increase invasiveness of the small cell lung cancer cell line SHP77. +other 33984882 hsa-mir-1301 Colorectal Neoplasms In the present study, we identified miR-1301 was enriched in normal colorectal tissues and significantly down-regulated in CRC. In summary, this study highlights the significant role of miR-1301/STAT3 axis in CRC metastasis. +lncRNA target 33984721 hsa-mir-211 Endometritis This study aims to investigate the regulatory role of miR-211 in the innate immune response involved in endometritis, and to evaluate its potential therapeutic value. Therefore, miR-211 has anti-inflammatory effects and mediates the negative regulation of the NF-kappaB signaling pathway in LPS-induced endometritis by targeting TAB1. +transcription factor target 33984719 hsa-mir-497 Corneal Neovascularization Mechanically, miR-497 might serve as a potential strategy for pathological corneal neovascularization via macrophage through the IL-6/STAT3/VEGFA signaling pathway. +genetics_GWAS 33984485 hsa-mir-26a Inflammation The knockdown of miR-26a ubiquitously resulted in a significant reduction of miR-26a in embryos, accompanied by impaired TnP immunomodulatory function observed by the loss of the control of the removal of neutrophils in response to inflammation, while the overexpression increased the inhibition of neutrophilic inflammation promoted by TnP. +transcription factor target 33984358 hsa-mir-145 Inflammatory Bowel Diseases The downregulation of miR-145 reduced the drug sensitivity of 5-aminosalicylic acid (5-ASA) and glucocorticoids in treating UC, indicating that miR-145 might be a potential therapeutic target for UC. +lncRNA target 33983643 hsa-mir-19a Colonic Neoplasms Our findings showed that lncRNA CASC2 inhibited cell viability in colon cancer cell lines and miR-19a reversed its functions through the NF-kappaB signalling pathway, suggesting that these could be factors in treating colon cancer in the future. +other 33982889 hsa-mir-10b Lupus Erythematosus, Systemic Importantly, hsa-miR-10b-5p expression levels were elevated in T cells from healthy women compared to healthy men and also elevated in T cells from SLE patients. +genetics_overexpression_promote 33982790 hsa-mir-454 Breast Neoplasms Overexpression of miR4545p promoted breast cancer cell viability, migration and invasion in vitro, whereas silencing of miR4545p inhibited breast cancer proliferation, migration and invasion in vitro and suppressed tumor growth in vivo. +transcription factor target 33982786 hsa-mir-29b Nasal Polyps In the present study, samples from 100 patients with CRSwNPs were examined via reverse transcriptionquantitative PCR to assess the mRNA expression of miR29b3p, and western blotting was performed to assess the protein expression of MMP2, MMP9, acetylalphatubulin, integrin beta1 and tissue inhibitor of metalloproteinase 1 (TIMP1). +genetics_overexpression_promote 33982777 hsa-mir-500a Stomach Neoplasms lncRNA NEAT1 overexpressionmediated inhibition of gastric cancer cell proliferation and invasion was significantly reversed by miR500a3p overexpression. The present study demonstrated that lncRNA NEAT1 inhibited gastric cancer cell proliferation and invasion, and promoted apoptosis by regulating the miR500a3p/XBP1 axis. +transcription factor target 33982775 hsa-mir-133b Cardiomyopathies Thus, the current results indicated that miR133b alleviated doxorubicininduced cardiomyocyte apoptosis and cardiac fibrosis by targeting PTBP1 and TAGLN2, implying that miR133b may be a potential biomarker for doxorubicininduced cardiac injury. +other 33982771 hsa-mir-23a Sepsis The expression of miR23a3p was downregulated whereas that of TLR4 was upregulated in the septic cells. +genetics_overexpression_promote 33982769 hsa-mir-198 Squamous Cell Carcinoma of Head and Neck In addition, transfection of small interfering RNA against CDK4 in OSCC cells showed similar inhibitory effects on cell proliferation, invasion and EMT, whereas CDK4 overexpression in OSCC cells partially reversed the inhibitory effects of the miR198 mimic. +genetics_knock down_promote 33982765 hsa-mir-635 Osteosarcoma Notably, mechanistic investigation revealed that lncRNA DUXAP8 predominantly acted as a competing endogenous RNA in OS by regulating the miR635/topoisomerase alpha 2 (TOP2A) axis. lncRNA DUXAP8 is upregulated in OS, and lncRNA DUXAP8knockdown serves a vital antitumor role in OS cell progression through the miR635/TOP2A axis. +lncRNA target 33982764 hsa-mir-24 Glioma Collectively, the present findings demonstrated that NEAT1 acted as a competing endogenous RNA for miR3245p, and identified the NEAT1/miR3245p/KCTD20 axis as a novel regulatory axis and a potential therapeutic target for human glioma. +exosome 33982667 hsa-mir-127 Glioma CONCLUSION: These results demonstrated that exosomal circRNA 0001445 promoted glioma progression through miRNA5p/SNX5 signaling pathway. +circulation_biomarker_diagnosis_ns 33982582 hsa-mir-215 Colorectal Neoplasms However, circulating mmu-miR +other 33982450 hsa-mir-210 Osteoporosis 3p showed to be increased. +circRNA target 33982351 hsa-mir-149 Liver Cirrhosis "Together, circUbe2k may act as a ""catalyst"" of HSCs activation and HF through the circUbe2k/miR5p/TGF-beta2 axis." +circRNA target 33982329 hsa-mir-24 Carcinoma, Hepatocellular CONCLUSION: This study suggested GL63 impeded the HCC development by blocking the JAK2/STAT3 signaling pathway via mediating the circZNF83/miR +circulation_biomarker_diagnosis_up 33982217 hsa-mir-532 Carcinoma, Hepatocellular RESULTS: A distinctive panel of HCC-related circulating miRNAs, including three upregulated miRNAs (miR-184, miR +circulation_biomarker_diagnosis_up 33982217 hsa-let-7b Carcinoma, Hepatocellular RESULTS: A distinctive panel of HCC-related circulating miRNAs, including three upregulated miRNAs (miR-184, miR +circulation_biomarker_diagnosis_up 33982217 hsa-mir-26b Carcinoma, Hepatocellular RESULTS: A distinctive panel of HCC-related circulating miRNAs, including three upregulated miRNAs (miR-184, miR +circulation_biomarker_diagnosis_up 33982217 hsa-mir-221 Carcinoma, Hepatocellular RESULTS: A distinctive panel of HCC-related circulating miRNAs, including three upregulated miRNAs (miR-184, miR +circulation_biomarker_diagnosis_up 33982217 hsa-mir-5589 Carcinoma, Hepatocellular RESULTS: A distinctive panel of HCC-related circulating miRNAs, including three upregulated miRNAs (miR-184, miR +circulation_biomarker_diagnosis_up 33982217 hsa-mir-184 Carcinoma, Hepatocellular RESULTS: A distinctive panel of HCC-related circulating miRNAs, including three upregulated miRNAs (miR-184, miR +circulation_biomarker_diagnosis_up 33981849 hsa-mir-107 Atherosclerosis Expression of circ_UBR4 and ROCK1 was upregulated, whereas miR-107 was downregulated in human AS serum and ox-LDL-induced VSMCs. circ_UBR4 might be a contributor in human AS partially by regulating VSMCs' cell proliferation, migration, and cell cycle progression via circ_UBR4/miR-107/ROCK1 pathway. +lncRNA target 33981845 hsa-mir-320c Osteoarthritis In this study, levels of TUG1 and FUT4 were distinctly upregulated, but miR-320c level significantly decreased in OA tissues and chondrocytes derived from OA tissues as well as in IL-1beta-stimulated C28/I2 cells. Collectively, TUG1 modulated cell proliferation, apoptosis and ECM degradation in IL-1beta-induced C28/I2 cells via the miR-320c/FUT4 axis, providing a new insight into the OA treatment. +lncRNA target 33981772 hsa-mir-137 Osteosarcoma circPVT1 and TRIAP1 were highly expressed, and miR-137 was decreased in DXR-resistant osteosarcoma tissues and cells. circPVT1 boosted DXR resistance of osteosarcoma cells partly by regulating the miR-137/TRIAP1 axis, hinting a promising therapeutic target for the osteosarcoma treatment. +transcription factor target 33981730 hsa-mir-205 Atrial Fibrillation Conclusion: The miR-205/P4HA3 axis is implicated in atrial fibrosis by inhibition of rat fibroblast proliferation and migration and the inactivation of JNK signaling pathway. +transcription factor target 33981730 hsa-mir-205 Fibrosis, Atrial Conclusion: The miR-205/P4HA3 axis is implicated in atrial fibrosis by inhibition of rat fibroblast proliferation and migration and the inactivation of JNK signaling pathway. +lncRNA target 33981611 hsa-mir-141 Squamous Cell Carcinoma of Head and Neck In conclusion, we demonstrated that circ_0032822 functions as a tumor oncogene in HNSCC and that its function is regulated via the miR-141/E2F3 axis. +genetics_overexpression_promote 33981482 hsa-mir-410 Atherosclerosis Furthermore, silencing miR-410 or overexpressing HDAC1 increased cell viability and suppressed apoptosis and an inflammatory reaction in HUVECs in atherosclerosis. +other 33981362 hsa-mir-1179 Breast Neoplasms Long non-coding RNA TMPO-AS1 facilitates chemoresistance and invasion in breast cancer by modulating the miR-1179/TRIM37 axis. +genetics_knock down_suppress 33981357 hsa-mir-182 Melanoma The overexpression of NUPR1 reversed the effects of DUXAP8 knockdown or miR-3182 mimic on melanoma progression. In conclusion, lncRNA DUXAP8 downregulation inhibits the development of melanoma by regulating the miR-3182/NUPR1 axis. +transcription factor target 33981308 hsa-mir-155 psoriasis 1 As the direct binding of tnfaip3 to miR-155 has been demonstrated by luciferase reporter assay, and Ebosin has been demonstrated to inhibit miR-155 level in vitro and in vivo, our study first indicates that Ebosin reduces inflammation through the miRtnfaip3-IL-17 axis and T cell differentiation in a psoriasis-like model. +target gene 33981163 hsa-mir-139 Carcinoma, Non-Small-Cell Lung MiR-139-5p Targetedly Regulates YAF2 and Mediates the AKT/P38 MAPK Signaling Pathway to Alleviate the Metastasis of Non-Small Cell Lung Cancer Cells and Their Resistance Against Cisplatin. +genetics_overexpression_promote 33981162 hsa-mir-34a Leukemia, Myeloid, Acute In AML cells, overexpression of circ_POLA2 decreased the expression levels of mature miR-34a, but not miR-34a precursor. +transcription factor target 33980925 hsa-mir-506 Cholangitis, Sclerosing, Primary MiR-506 was substantially upregulated in ascending colons of PSC and PSC UC patients, in contrast to sigmoid colons of PSC and UC patients. In ascending colons with PSC UC, upregulation of miR-506 may result in failure of bicarbonate secretion and inhibition of p53, which predisposes to pro-tumorigenic transformation. +transcription factor target 33980925 hsa-mir-506 Inflammatory Bowel Diseases MiR-506 was substantially upregulated in ascending colons of PSC and PSC UC patients, in contrast to sigmoid colons of PSC and UC patients. In ascending colons with PSC UC, upregulation of miR-506 may result in failure of bicarbonate secretion and inhibition of p53, which predisposes to pro-tumorigenic transformation. +other 33980826 hsa-mir-125a Melanoma Moreover, we identified hsa-miR-125a-5p|0|-2 isoform as tenfold over-represented in melanoma than the canonical form and differentially expressed in MPMs arising in the same patient. +genetics_knock down_suppress 33980772 hsa-mir-879 Inflammation Circ_0000712 knockdown could hinder HG-inducted SV40-MES13 cell injury through targeting the miR +genetics_knock down_suppress 33980772 hsa-mir-879 Diabetic Nephropathies Circ_0000712 knockdown could hinder HG-inducted SV40-MES13 cell injury through targeting the miR +genetics_overexpression_promote 33980319 hsa-mir-182 Asthma In addition, in vivo overexpression of EGR2 countered the promoting effect of the YAP/HIF-1alpha/miR-182 axis on asthma and lipid metabolism dysfunction. +circulation_biomarker_diagnosis_up 33980140 hsa-mir-15a Sepsis METHODS: Expression of circFADS2, mature miR-15a-5p, and miR-15a-5p precursor in plasma samples from sepsis patients and healthy controls was determined by RT-qPCR. +circRNA target 33979737 hsa-mir-513a Stomach Neoplasms circBFAR was proven to promote GC proliferation by targeting the miR-513a-3p/hexokinase 2 (HK2) axis. In this study, we found a circBFAR/miR-513a-3p/HK2 axis in GC and revealed the relationship between circBFAR and glycolysis for the first time. +genetics_overexpression_suppress 33979697 hsa-mir-148a Alzheimer Disease Overexpression of miR-148a-3p attenuated Abeta induced neurotoxicity in AD by targeting ROCK1. +lncRNA target 33979576 hsa-mir-132 Autoimmune Diseases More importantly, miR-132 inhibits LPS-induced NF-kappaB signaling pathway by targeting IL-1beta, thereby preventing excessive inflammatory response from causing autoimmune diseases. +other 33979314 hsa-mir-210 Primary Graft Dysfunction A different linear combination of miR-34a miR-210 (P < 0.0001) was the best model for discriminating NINV-AR from R-HCV with intragraft inflammation, and miR-34a miR-122 (P < 0.0001) was the best model for discriminating NINV-AR from R-HCV with intragraft fibrosis. +other 33979314 hsa-mir-34a Hepatitis C A different linear combination of miR-34a miR-210 (P < 0.0001) was the best model for discriminating NINV-AR from R-HCV with intragraft inflammation, and miR-34a miR-122 (P < 0.0001) was the best model for discriminating NINV-AR from R-HCV with intragraft fibrosis. +other 33979314 hsa-mir-34a Primary Graft Dysfunction A different linear combination of miR-34a miR-210 (P < 0.0001) was the best model for discriminating NINV-AR from R-HCV with intragraft inflammation, and miR-34a miR-122 (P < 0.0001) was the best model for discriminating NINV-AR from R-HCV with intragraft fibrosis. +other 33979314 hsa-mir-122 Primary Graft Dysfunction A different linear combination of miR-34a miR-210 (P < 0.0001) was the best model for discriminating NINV-AR from R-HCV with intragraft inflammation, and miR-34a miR-122 (P < 0.0001) was the best model for discriminating NINV-AR from R-HCV with intragraft fibrosis. +other 33979314 hsa-mir-210 Hepatitis C A different linear combination of miR-34a miR-210 (P < 0.0001) was the best model for discriminating NINV-AR from R-HCV with intragraft inflammation, and miR-34a miR-122 (P < 0.0001) was the best model for discriminating NINV-AR from R-HCV with intragraft fibrosis. +other 33979314 hsa-mir-122 Hepatitis C A different linear combination of miR-34a miR-210 (P < 0.0001) was the best model for discriminating NINV-AR from R-HCV with intragraft inflammation, and miR-34a miR-122 (P < 0.0001) was the best model for discriminating NINV-AR from R-HCV with intragraft fibrosis. +circulation_biomarker_diagnosis_ns 33978942 hsa-mir-146b Pneumonia In conclusion, the relative expression of miR-146b in serum of infantile pneumonia decreased, and over-expressing it could promote LPS-induced cell viability and reduce apoptosis. +lncRNA target 33978928 hsa-mir-16 Sepsis Collectively, it is concluded that XIST reduces sepsis-induced ALI via regulating miR +lncRNA target 33978928 hsa-mir-16 Lung Injury Collectively, it is concluded that XIST reduces sepsis-induced ALI via regulating miR +lncRNA target 33978765 hsa-mir-145 Diabetes Mellitus Silencing circANKRD36 alleviated the inflammation and suppressed cell apoptosis in the pancreatic tissues of T2DM rats, which was abated by miR-145 inhibitor. Additionally, miR-145 inhibitor increased the level of XBP1 in T2DM rats, which was decreased in the presence of circANKRD36 silencing. +lncRNA target 33978765 hsa-mir-145 Inflammation Silencing circANKRD36 alleviated the inflammation and suppressed cell apoptosis in the pancreatic tissues of T2DM rats, which was abated by miR-145 inhibitor. Additionally, miR-145 inhibitor increased the level of XBP1 in T2DM rats, which was decreased in the presence of circANKRD36 silencing. +circRNA target 33978716 hsa-mir-195 Prostatic Neoplasms Overall, our study demonstrated that hsa_circ_0062019 promoted PCa cell proliferation, migration, and invasion via upregulation of HMGA2 expression by sponging miR5p. +circulation_biomarker_prognosis_ns 33978382 hsa-mir-182 Intervertebral Disc Degeneration RESULTS: The expression level of miR-182 was dramatically increased in plasma samples of IDD patients compared with the controls. +circulation_biomarker_diagnosis_up 33978365 hsa-mir-429 Diabetes, Gestational CONCLUSIONS: In summary, the increase of serum and urine miR-429 level is a risk factor of insulin resistance in pregnant women with GDM. +lncRNA target 33978322 hsa-mir-29c Multiple Sclerosis Further, using state-of-the-art human protein-protein interactome network analysis, we mapped the four key GM atrophy-associated miRNAs (hsa-miR-149*, hsa-miR-20a, hsa-miR-29c, and hsa-miR-25) to their target mRNAs that were also changed in GMLs. +lncRNA target 33978322 hsa-mir-25 Multiple Sclerosis Further, using state-of-the-art human protein-protein interactome network analysis, we mapped the four key GM atrophy-associated miRNAs (hsa-miR-149*, hsa-miR-20a, hsa-miR-29c, and hsa-miR-25) to their target mRNAs that were also changed in GMLs. +lncRNA target 33978322 hsa-mir-20a Multiple Sclerosis Further, using state-of-the-art human protein-protein interactome network analysis, we mapped the four key GM atrophy-associated miRNAs (hsa-miR-149*, hsa-miR-20a, hsa-miR-29c, and hsa-miR-25) to their target mRNAs that were also changed in GMLs. +genetics_GWAS 33978320 hsa-mir-3130 Adenocarcinoma of Lung 5p as an intermediate modulator of risk loci 2q33 and the tumor suppressor NDUFS1. +circulation_biomarker_prognosis_ns 33978071 hsa-mir-215 Stomach Neoplasms Furthermore, serum EV-miR +genetics_knock down_promote 33977869 hsa-mir-141 Cicatrix, Hypertrophic INHBA-AS1-knockdown suppresses the formation of HS by regulating miR +genetics_overexpression_promote 33977112 hsa-mir-34a Liver Cirrhosis RESULTS: We found that miR-34a was overexpressed in the peripheral blood in PBC patients. +genetics_overexpression_promote 33977112 hsa-mir-34a Cholangitis, Biliary, Primary RESULTS: We found that miR-34a was overexpressed in the peripheral blood in PBC patients. +circulation_biomarker_diagnosis_up 33976977 hsa-mir-23b Osteoporosis RESULTS: Decreased expression of TUG1 and increased expression of miR-23b evident in the plasma of patients with osteoporosis than in that of age- and sex-matched healthy controls. +target gene 33976749 hsa-mir-515 Thyroid Neoplasms ZFPM2-AS1 transcriptionally mediated by STAT1 regulates thyroid cancer cell growth, migration and invasion via miR-515-5p/TUSC3. +lncRNA target 33976745 hsa-mir-1224 Glioma Conclusion: Together, our results revealed that circ-ZNF609 elevates glioma growth and metastasis via enforcing PLK1 expression by competitively binding miR +circRNA target 33976734 hsa-mir-1243 Glioma 5p/RMI1 in glioma and suggests that this axis may be a novel therapeutic target in glioma. +lncRNA target 33976730 hsa-mir-193b Stomach Neoplasms To sum up, these experimental results demonstrated that BLACAT2 acted as an oncogene in gastric cancer progression through the regulation of the miR-193b-5p/METTL3 pathway, hence providing new insights regarding the pathogenesis of gastric cancer. +transcription factor target 33976725 hsa-mir-202 Colorectal Neoplasms 5p resulted in CRC cell proliferation inhibition and enhancement, respectively. +exosome 33976535 hsa-mir-1182 Prostatic Neoplasms RESULTS: Circ-XIAP and TPD52 were upregulated and miR-1182 was downregulated in DTX-resistant PCa tissue specimens and cell lines. CONCLUSION: Exosomal circ-XIAP promoted DTX resistance of PCa by regulating miR-1182/TPD52 axis, providing a promising therapeutic target for PCa chemotherapy. +exosome 33976355 hsa-mir-21 Rett Syndrome In the present study, we sought to determine whether that exosomal miR5p from USCs could promote early neural formation in a model of RTT. +lncRNA target 33976115 hsa-mir-124 Esophageal Squamous Cell Carcinoma Taken together, we identified that CircRNA_2646 functioned as an inhibitor in miR-124 signaling pathway in ESCC for carcinogenesis and could be a promising target for ESCC therapy. +exosome 33975615 hsa-mir-1252 Glioma CONCLUSION: Exosomal circ_0072083 promoted TMZ resistance via increasing NANOG via regulating miR5p-mediated degradation and demethylation in glioma. +genetics_knock down_promote 33975612 hsa-mir-127 Osteoarthritis CONCLUSION: Circ_0128846 knockdown might inhibit the progression of OA by upregulating miR +lncRNA target 33975517 hsa-mir-16 Stomach Neoplasms 5p, resulting in the recovery of the Hippo pathway, which suppressed the expression levels of the downstream oncogenes, including EGFR, SOX2 and OCT4, leading to the inhibition of the malignant phenotypes in GC cells. +other 33975327 hsa-mir-432 Reperfusion Injury, Renal Ischemia 3p) affects inflammation in both RI-RI rats and NRK52E cells. +other 33975264 hsa-mir-516b MASA syndrome RNA Sequencing showed microRNA (miR) miR-516b-5p, was present at significantly lower levels in L/PT-DMSCs. +lncRNA target 33975060 hsa-mir-548s Pancreatic Carcinoma RESULTS: We identified the CAV1-CAV2 locus tagged by rs8940 was significantly associated with PDAC prognosis, and rs10249656 in the 3'untranslated region of CAV2 was the real functional variant, which upregulated CAV2 expression through abolishing miR-548s binding. +circulation_biomarker_prognosis_ns 33974530 hsa-mir-9 Carotid Stenosis Serum miR +lncRNA target 33974352 hsa-mir-22 Stomach Neoplasms Overall, NCK1-AS1 functions as an oncogene and promotes gastric cancer progression via the miR3p/BCL9-Wnt/beta-catenin signaling pathway. +other 33974163 hsa-mir-142 Ovarian Neoplasms 5p/PD-L1 axis is involved in regulating OC progression. +circRNA target 33973871 hsa-mir-96 Fibrosis, Renal 5p/HBEGF/KRAS axis and suggest that circRNA_30032 is a potential therapeutic target for treatment of renal fibrosis. +other 33973644 hsa-mir-486 Carcinoma, Squamous Cell 5p expression profiles. +other 33973644 hsa-mir-126 Carcinoma, Squamous Cell 5p expression profiles. +other 33973644 hsa-mir-182 Carcinoma, Squamous Cell The aim of this study was to analyze mir-126, mir-182, and mir5p expression levels in head and neck SCCs and lung SCCs, and to identify localization-specific miRNA expression profiles. +other 33973497 hsa-mir-199a Ventricular Premature Complexes Dynamic changes in miR-222, miR-199a, miR-195, and miR-125b induced by VC can lead to cell cycle deregulation by affecting cell cycle-related proteins, and these miRNAs can serve as early biomarkers for malignant transformation caused by VC. +other 33973497 hsa-mir-125b Ventricular Premature Complexes Dynamic changes in miR-222, miR-199a, miR-195, and miR-125b induced by VC can lead to cell cycle deregulation by affecting cell cycle-related proteins, and these miRNAs can serve as early biomarkers for malignant transformation caused by VC. +other 33973497 hsa-mir-195 Ventricular Premature Complexes Dynamic changes in miR-222, miR-199a, miR-195, and miR-125b induced by VC can lead to cell cycle deregulation by affecting cell cycle-related proteins, and these miRNAs can serve as early biomarkers for malignant transformation caused by VC. +other 33973497 hsa-mir-222 Ventricular Premature Complexes Dynamic changes in miR-222, miR-199a, miR-195, and miR-125b induced by VC can lead to cell cycle deregulation by affecting cell cycle-related proteins, and these miRNAs can serve as early biomarkers for malignant transformation caused by VC. +transcription factor target 33973278 hsa-mir-4286 Osteoporosis CONCLUSIONS: We firstly demonstrated that miR-4286 might function via intimate osteogenesis-angiogenesis pathway to alleviate alcohol-induced osteopenia via targeting HDAC3. +transcription factor target 33973278 hsa-mir-4286 Alcoholism CONCLUSIONS: We firstly demonstrated that miR-4286 might function via intimate osteogenesis-angiogenesis pathway to alleviate alcohol-induced osteopenia via targeting HDAC3. +other 33973132 hsa-mir-454 DiGeorge Syndrome The expressions of miR3p, lncRNA-DiGeorge syndrome critical region gene 5 (DGCR5) and growth arrest and DNA damage protein-inducible 45A (GADD45A) in placental tissues from PE patients or HTR-8/SVneo cells were assessed by Western blot or qRT-PCR. +lncRNA target 33973132 hsa-mir-454 Pneumonia, Mycoplasma 3p increased viability and promoted migration, invasion and tube formation in HTR-8/SVneo cells while inhibiting apoptosis. +genetics_overexpression_promote 33972506 hsa-mir-296 Lung Neoplasms Inhibited AGAP2-AS1, macrophage-derived exosomes, and exosomes overexpressing AGAP2-AS1 or inhibiting miR-296 facilitated the malignant phenotypes of radioresistant lung cancer cells. +transcription factor target 33972468 hsa-mir-20b Ischemic Stroke, Cerebral Our study demonstrated that upregulation of miR-20b protected the brain from ischemic brain injury by targeting TXNIP, extending our understanding of miRNAs in cerebral ischemic stroke. +transcription factor target 33971623 hsa-mir-205 Breast Neoplasms These results collectively indicated the tumor-suppressive role of miR-205 in breast cancer by targeting CLDN11; implying miR-205 may serve as a novel therapeutic target for breast cancer. +genetics_overexpression_promote 33971546 hsa-mir-133b Adenocarcinoma of Lung The results of in vitro functional experiments showed that overexpression of CDCA8 could promote the proliferation, invasion, and migration of LUAD cells, and miR-133b could reverse this promotion by targeting CDCA8. +circRNA target 33971492 hsa-mir-153 Osteoarthritis CONCLUSION: Taken together, the results in this study suggested that circATRNL1 might ameliorate the development and progression of OA through regulating miR3p/KLF5 axis. +exosome 33971282 hsa-mir-338 Pancreatic Carcinoma Overall, BM-MSC exosomal circ_0030167 contributes to the progression and stemness of PC cells via the miR +other 33970852 hsa-mir-16-1 Squamous Cell Carcinoma of Head and Neck 1 in OSCC indicates the possible effective role of these genes in OSCC etiopathogenesis. +other 33970852 hsa-mir-16 Squamous Cell Carcinoma of Head and Neck 1 in OSCC indicates the possible effective role of these genes in OSCC etiopathogenesis. +other 33970852 hsa-mir-15a Squamous Cell Carcinoma of Head and Neck 1 in OSCC indicates the possible effective role of these genes in OSCC etiopathogenesis. +genetics_knock down_suppress 33969901 hsa-mir-5195 Leukemia, Myeloid, Acute Meanwhile, the role of circ_0009910 knockdown in AML cells was partially reversed by miR +circulation_biomarker_diagnosis_up 33969722 hsa-mir-210 Colorectal Neoplasms 3p in circulating plasma exosomes was markedly upregulated in colorectal cancer patients, which were closely associated with multiple unfavorable clinicopathological features. +lncRNA target 33969374 hsa-mir-613 Leukemia In conclusion, UCA1 up-regulation facilitated the resistance of acute leukemia cells to DNR via the PI3K/AKT pathway by sponging miR-613. +lncRNA target 33969134 hsa-mir-374 Colorectal Neoplasms Hsa-miR-374 might be as a helpful biomarker or therapeutic target in CRC. +lncRNA target 33969134 hsa-mir-374a Colorectal Neoplasms Hsa-miR-374 might be as a helpful biomarker or therapeutic target in CRC. +genetics_GWAS 33969131 hsa-mir-612 Precursor Cell Lymphoblastic Leukemia-Lymphoma A previous study suggested that mir-612 rs12803915 G> A may be associated with pediatric ALL risk. CONCLUSION: HRM is a suitable method to detect SNP rs12803915 in the mir-612 gene; however, we found no significant association between the rs12803915 polymorphism and ALL risk. +lncRNA target 33969128 hsa-mir-106b Carcinoma, Renal Cell Conclusively, circ-ITCH suppresses ccRCC metastasis by enforcing PDCD4 expression through binding miR-106b-5p. +transcription factor target 33969024 hsa-mir-200a Heart Diseases Interestingly, miR-200a-3p inhibition in activated FBs, alleviated TGF-beta1-FB-Exo-mediated endothelial dysfunction. +target gene 33968986 hsa-mir-210 Pancreatic Neoplasms Long Non-coding RNA DLEU2L Targets miR-210-3p to Suppress Gemcitabine Resistance in Pancreatic Cancer Cells via BRCA2 Regulation. +genetics_knock down_promote 33968966 hsa-mir-147a Carcinoma, Non-Small-Cell Lung Mechanically, miR-147a/IFITM1 axis was a downstream target of LINC00847, and silencing of miR-147a could rescue the anti-cancer effects of LINC00847 knockdown on NSCLC cell behaviors. Conclusion: Overall, up regulation of LINC00847 induced by E2F1 promoted the progression of NSCLC by modulating miR-147a/IFITM1 axis, representing a novel regulatory mechanism for NSCLC progression. +circRNA target 33968929 hsa-mir-411 Osteosarcoma Briefly, circSIPA1L1 could function as a driver gene in OS and initiate OS tumorigenesis through the miR5p/RAB9A signaling pathway, which might become a potential therapeutic biomarker for OS treatment. +lncRNA target 33968923 hsa-mir-146a Amyotrophic Lateral Sclerosis These results propose miR-146a as a new causal and emerging therapeutic target for astrocyte pathogenic processes in ALS. +transcription factor target 33968853 hsa-mir-24 Nephrosis, Lipoid There were lower levels of miR-24 and miR-27 in children with active non-atopic INS (P < 0.05). miR-24 and miR-27 suppressed the expression of Th2 cells and have a critical function regulating Th2 cell expression in INS. +transcription factor target 33968853 hsa-mir-27 Nephrosis, Lipoid There were lower levels of miR-24 and miR-27 in children with active non-atopic INS (P < 0.05). miR-24 and miR-27 suppressed the expression of Th2 cells and have a critical function regulating Th2 cell expression in INS. +genetics_overexpression_promote 33968785 hsa-mir-346 Carcinoma, Non-Small-Cell Lung Dual-luciferase reporter assays were also carried out to reveal the interaction between miR-346 and the 3' untranslated region (3'UTR) of adenomatous polyposis coli (APC) mRNA.Our data demonstrated that overexpression of lncRNA GHRLOS suppressed cancer cell proliferation and invasion as well as promoted cell apoptosis by regulating the expression of CDK2, PCNA, E-cadherin, N-cadherin, Bax, and Bcl-2 in NSCLC cells. In summary, this study reveals lncRNA GHRLOS, upregulated by TP53, acts as a molecule sponge of miR-346 to cooperatively modulates expression of APC, a miR-346 target, and potentially inhibits NSCLC progression via TP53/lncRNA GHRLOS/miR-346/APC axis, which represents a novel pathway that could be useful in targeted therapy against NSCLC. +genetics_knock down_promote 33968763 hsa-mir-137 Squamous Cell Carcinoma of Head and Neck 3p expression rescued the suppressive behaviors of LINC01929 knockdown on the biological behaviors of OSCC cells. +target gene 33968726 hsa-mir-375 Carcinoma, Non-Small-Cell Lung Long Noncoding RNA MLK7-AS1 Promotes Non-Small-Cell Lung Cancer Migration and Invasion via the miR-375-3p/YWHAZ Axis. +lncRNA target 33968711 hsa-mir-451a Colonic Neoplasms RESULTS: After validation through four algorithms, we obtained a 4-miRNA pair model (miR-1246 miR-451a; miR-1246 miR-4514; miR5p miR-575; miR-4299 miR-575) that showed good performance in differentiating CC from normal controls with a maximum AUC of 1.00 in internal verification and 0.93 in external verification. +lncRNA target 33968711 hsa-mir-4299 Colonic Neoplasms RESULTS: After validation through four algorithms, we obtained a 4-miRNA pair model (miR-1246 miR-451a; miR-1246 miR-4514; miR5p miR-575; miR-4299 miR-575) that showed good performance in differentiating CC from normal controls with a maximum AUC of 1.00 in internal verification and 0.93 in external verification. +lncRNA target 33968711 hsa-mir-654 Colonic Neoplasms RESULTS: After validation through four algorithms, we obtained a 4-miRNA pair model (miR-1246 miR-451a; miR-1246 miR-4514; miR5p miR-575; miR-4299 miR-575) that showed good performance in differentiating CC from normal controls with a maximum AUC of 1.00 in internal verification and 0.93 in external verification. +lncRNA target 33968711 hsa-mir-575 Colonic Neoplasms RESULTS: After validation through four algorithms, we obtained a 4-miRNA pair model (miR-1246 miR-451a; miR-1246 miR-4514; miR5p miR-575; miR-4299 miR-575) that showed good performance in differentiating CC from normal controls with a maximum AUC of 1.00 in internal verification and 0.93 in external verification. +target gene 33968662 hsa-mir-335 Urinary Bladder Neoplasms LncRNA DANCR regulates lymphatic metastasis of bladder cancer via the miR-335/VEGF-C axis. +other 33968653 hsa-mir-371a Fibrosis Conclusions By combining miR-371a-3p and miR5p in pcRPLND tissue samples V and T could be distinguished from necrosis/fibrosis with great accuracy. +other 33968653 hsa-mir-371a Teratoma Conclusions By combining miR-371a-3p and miR5p in pcRPLND tissue samples V and T could be distinguished from necrosis/fibrosis with great accuracy. +other 33968653 hsa-mir-375 Teratoma Conclusions By combining miR-371a-3p and miR5p in pcRPLND tissue samples V and T could be distinguished from necrosis/fibrosis with great accuracy. +other 33968653 hsa-mir-375 Fibrosis Conclusions By combining miR-371a-3p and miR5p in pcRPLND tissue samples V and T could be distinguished from necrosis/fibrosis with great accuracy. +other 33968586 hsa-mir-210 Fibrosis Taken together, the present study suggests that TGFbeta-induced miR5p reduced STAT5A expression, leading to aberrant activation of STAT3, and facilitate skin fibrosis in HDFs. +circulation_biomarker_diagnosis_ns 33968296 hsa-mir-501 Instent Restenosis Collectively, these findings showed that plasma sEV-carried miRNA +other 33968210 hsa-mir-665 Stomach Neoplasms MicroRNA-665 regulates the proliferation, apoptosis and adhesion of gastric cancer cells by binding to cadherin 3. +genetics_knock down_promote 33968209 hsa-mir-98 Nasopharyngeal Carcinoma Furthermore, miR-98 inhibition counteracted the inductive effect of HOXA11-AS-knockdown on the DDP sensitivity of NPC cells. +target gene 33968202 hsa-mir-1244 Prostatic Neoplasms Circular RNA UBAP2 promotes the proliferation of prostate cancer cells via the miR-1244/MAP3K2 axis. +target gene 33968198 hsa-mir-204 Lung Neoplasms MicroRNA-204 plays a role as a tumor suppressor in Newcastle disease virus-induced oncolysis in lung cancer A549 cells. +target gene 33968197 hsa-mir-188 Colonic Neoplasms miR-188-5p promotes oxaliplatin resistance by targeting RASA1 in colon cancer cells. +target gene 33968189 hsa-mir-219a Thyroid Neoplasms MicroRNA-219a-2-3p modulates the proliferation of thyroid cancer cells via the HPSE/cyclin D1 pathway. +other 33968182 hsa-mir-221 Thyroid Neoplasms miR-221-3p and miR-222-3p regulate the SOCS3/STAT3 signaling pathway to downregulate the expression of NIS and reduce radiosensitivity in thyroid cancer. +other 33968182 hsa-mir-222 Thyroid Neoplasms miR-221-3p and miR-222-3p regulate the SOCS3/STAT3 signaling pathway to downregulate the expression of NIS and reduce radiosensitivity in thyroid cancer. +genetics_knock down_suppress 33968176 hsa-mir-155 Osteosarcoma Knockdown of NORAD and transfection of miR +exosome 33968135 hsa-mir-20a Acute-On-Chronic Liver Failure Altogether, our data suggest that the exosomal miR-20a-5p/intracellular CXCL8 axis may play an important role in the reduction of liver inflammation in ACLF in the context of MSC-based therapies and highlights CXCL8 as a potential target for alleviating liver injury. +other 33967958 hsa-mir-21 Renal Tubule Ischemia Pathological concentrations of insulin and glucose in the IGT stage may lead to a decrease in miR-21 expression, thereby disordering the secretion of vasoactive factors, resulting in renal tubule ischemia. +other 33967958 hsa-mir-21 Retinitis Pathological concentrations of insulin and glucose in the IGT stage may lead to a decrease in miR-21 expression, thereby disordering the secretion of vasoactive factors, resulting in renal tubule ischemia. +other 33967958 hsa-mir-21 Acute Lung Injury Pathological concentrations of insulin and glucose in the IGT stage may lead to a decrease in miR-21 expression, thereby disordering the secretion of vasoactive factors, resulting in renal tubule ischemia. +other 33967607 hsa-mir-29a Diabetes Mellitus, Type 2 The function prediction results showed that has_circ_0071106 was involved in biological processes such as protein binding, gene transcription, and may be involved in the pathway of hsa-miR-29a-5p regulating diabetes, has_circ_0071106 may be used as a diagnostic marker for T2DM. +circulation_biomarker_diagnosis_up 33966404 hsa-mir-181a Cicatrix, Hypertrophic METHODS HSFb cells were transfected with miR-negative control (miR-NC), miR-181a mimics, miR-181a inhibitor, pcDNA3.1-PTEN (pc-PTEN), or small interfence-PTEN (si-PTEN) plasmid using a Lipofectamine 2000 transfection kit. +genetics_knock down_suppress 33966370 hsa-mir-19a Lung Injury This study aimed to investigate the role of miR-19a-3p and its regulation mechanism in sepsis-induced lung injury. In conclusion, miR-19a-3p knockdown could alleviate sepsis-induced lung injury through enhancing USP13 expression. +genetics_knock down_suppress 33966370 hsa-mir-19a Sepsis This study aimed to investigate the role of miR-19a-3p and its regulation mechanism in sepsis-induced lung injury. In conclusion, miR-19a-3p knockdown could alleviate sepsis-induced lung injury through enhancing USP13 expression. +other 33966214 hsa-mir-203a Acidosis In NCI-H358 lung cancer cells, miR-203a expression was repressed by acidosis. +lncRNA target 33966211 hsa-mir-203 Acidosis Since acidosis modulates the expression of different microRNAs (e.g., miR-7, miR-183, miR-203, miR-215), microRNAs and their targets might be mediators between tumor acidosis and malignant behavior. +lncRNA target 33966211 hsa-mir-215 Acidosis Since acidosis modulates the expression of different microRNAs (e.g., miR-7, miR-183, miR-203, miR-215), microRNAs and their targets might be mediators between tumor acidosis and malignant behavior. +lncRNA target 33965964 hsa-mir-182 Reperfusion Injury By using miR-182 antagomir, the I/R injury was markedly ameliorated. CONCLUSIONS: Our results demonstrate that miR-182 promotes cell apoptosis and I/R injury through directly binding to FoxO3. +lncRNA target 33965958 hsa-mir-149 Uterine Cervical Neoplasms CONCLUSION: ARAP1-AS1 was abnormally upregulated in CC tissues and indirectly modulated the POU2F2 expression via reducing miR +other 33965787 hsa-mir-29a Stomach Neoplasms In brief, we confirmed that circ29, as a sponge of miR-29a, plays a responsible role in the occurrence and development of GC by regulating the VEGF pathway. +genetics_knock down_suppress 33965771 hsa-mir-206 Angelman Syndrome CONCLUSION: MIAT knockdown impaired ox-LDL-induced HUVEC injury via regulating miR-206/RAB22A axis, suggesting the potential impacts of MIAT on AS occurrence, which revealed a potential therapeutic strategy for future clinic intervention in AS. +other 33965507 hsa-mir-204 Trichohepatoenteric Syndrome In our previous study, we found that miR-204 was highly expressed in the ileum tissues of the susceptible group diarrhea piglets after infection with Clostridium perfringens (C. +lncRNA target 33964939 hsa-mir-129 Arthritis, Rheumatoid 5p was found to directly target HIPK2, and suppressed the tumor-like biologic behaviors and inflammation of RA-FLSs via regulating HIPK2. +transcription factor target 33964876 hsa-mir-128 Coronary Disease 3p had higher degrees, CTSB/CTSD could be targeted by them. +transcription factor target 33964876 hsa-mir-24 Coronary Disease 3p had higher degrees, CTSB/CTSD could be targeted by them. +other 33964458 hsa-mir-166 Genetic Diseases, Inborn Under cold growing conditions, SlHB15A is subjected to conditional haploinsufficiency and recessive dosage sensitivity controlled by microRNA 166 (miR166). +transcription factor target 33964297 hsa-mir-19b Carcinoma, Non-Small-Cell Lung SIGNIFICANCE: In conclusion, this study demonstrates that MYPT1, regulated by miR-19b-3p, inhibits the progression of NSCLC via inhibiting the activation of wnt/beta-catenin signaling. +genetics_overexpression_promote 33964276 hsa-mir-1 Yellow Nail Syndrome Here, we investigated the role of miR-1 overexpression in the development and function of sinoatrial (SAN) cells using murine embryonic stem cells (mESC). +other 33964276 hsa-mir-1 Heart Diseases Conditions affecting the heart rate, such as endurance training and cardiac diseases, show a concomitant miR-1 up- or down-regulation. +lncRNA target 33963706 hsa-mir-23a Osteoarthritis OBJECTIVE: XFC can reduce the inflammatory response in patients with OA by down-regulating the expression of miR-23a-3p, inhibiting the activation of the PTEN/PI3K/AKT/ mTOR pathway, and regulating the expression of IL-1beta, IL-6, IL-10 and TNF-alpha. +genetics_knock down_suppress 33962944 hsa-mir-210 Inflammation MiR-210 knockout in the hematopoietic lineage or in monocytes/macrophages mitigated the symptoms of endotoxemia, bacteremia, sepsis, and parasitosis, limiting the cytokine storm, organ damage/dysfunction, pathogen spreading, and lethality. +genetics_knock down_promote 33962657 hsa-mir-455 Thyroid cancer, medullary Knockdown of circPVT1 or miR +genetics_knock down_promote 33962616 hsa-mir-578 Osteosarcoma CONCLUSION: Circ-CNST knockdown could antagonize malignant behaviors and glycolysis of OS cells by regulating miR +lncRNA target 33962397 hsa-mir-34a Glioma Through analysis and dual-luciferase report assay, we found that circITGA7 acts as a sponge for miR-34a-5p targeting VEGFA in glioma. +circulation_biomarker_diagnosis_up 33962174 hsa-mir-362 Breast Neoplasms RESULTS: Six upregulated blood miRNAs (miR-26b-5p, miR-106b-5p, miR +circulation_biomarker_diagnosis_up 33962174 hsa-mir-106b Breast Neoplasms RESULTS: Six upregulated blood miRNAs (miR-26b-5p, miR-106b-5p, miR +circulation_biomarker_diagnosis_up 33962174 hsa-mir-142 Breast Neoplasms RESULTS: Six upregulated blood miRNAs (miR-26b-5p, miR-106b-5p, miR +circulation_biomarker_diagnosis_up 33962174 hsa-mir-26b Breast Neoplasms RESULTS: Six upregulated blood miRNAs (miR-26b-5p, miR-106b-5p, miR +circulation_biomarker_diagnosis_up 33962174 hsa-mir-185 Breast Neoplasms RESULTS: Six upregulated blood miRNAs (miR-26b-5p, miR-106b-5p, miR +exosome 33961985 hsa-mir-21 Pulmonary Fibrosis In conclusion, the results reveal that, in CS-induced pulmonary fibrosis, circRNA_0026344, via exosomal miR-21 regulation of Smad7, is involved in aberrant cross-talk of epithelium-fibroblasts. +other 33961875 hsa-mir-200 Diabetes Mellitus The microRNA (miR)-200 family, specifically miR-141, is differentially expressed in diseased states including cognitive decline, thereby triggering changes in downstream genes. +lncRNA target 33961855 hsa-mir-495 Colorectal Neoplasms SIGNIFICANCE: UCA1-miRSP1/SP3 axis is dysregulated in CRC and contributed to malignant phenotypes of CRC. +transcription factor target 33961841 hsa-mir-199a Acute Lung Injury SIGNIFICANCE: These findings reveal that irisin can alleviate ALI by inhibiting miR-199a and upregulating Rad23b expression, suggesting that irisin has clinical potential for the treatment of ALI. +genetics_overexpression_promote 33961511 hsa-mir-485 Osteoarthritis CONCLUSION: Overexpression of miR +other 33961505 hsa-mir-222 Celiac Disease 3p increased specifically in CA HUVECs (72% and 53%, P = 0.04 and P = 0.06), whereas others did not change in either race. +other 33960958 hsa-mir-7977 Addison Disease miR-7977 was upregulated in patients with coexisting autoimmune conditions vs those with isolated AD (P = 0.005, mean FC = 2.2). CONCLUSIONS: Our study demonstrates upregulated expression of miR-7977 in CD4+ T cells from patients with AD, especially with its polyendocrine form. +genetics_knock down_suppress 33960555 hsa-mir-4498 Osteoarthritis We further determined that miR-4498 inhibitor reversed circSLC7A2-knockdown-induced OA phenotypes. CONCLUSIONS: The circSLC7A2/miR-4498/TIMP3 axis of chondrocytes catabolism and anabolism plays a critical role in OA development. +circulation_biomarker_diagnosis_ns 33960307 hsa-mir-660 ST Elevation Myocardial Infarction CONCLUSION: Circulating miR +genetics_overexpression_promote 33960055 hsa-mir-21 Infertility 5p, which is associated with inflammation, is overexpressed in the unexplained infertile group (*p < .05). +genetics_overexpression_promote 33960055 hsa-mir-155 Infertility 5p, which is associated with inflammation, is overexpressed in the unexplained infertile group (*p < .05). +other 33959794 hsa-mir-26a Rift Valley Fever The results suggest the potential application of miR-26a in the treatment of RIF. +other 33959659 hsa-mir-93 Familial Primary Pulmonary Hypertension 5p expression was associated with the severity of CTEPH and could act as a potential predictor of high-risk CTEPH. +other 33959615 hsa-mir-222 Carcinoma, Non-Small-Cell Lung Reck-Notch1 Signaling Mediates miR-221/222 Regulation of Lung Cancer Stem Cells in NSCLC. +other 33959615 hsa-mir-221 Carcinoma, Non-Small-Cell Lung Reck-Notch1 Signaling Mediates miR-221/222 Regulation of Lung Cancer Stem Cells in NSCLC. +other 33959608 hsa-mir-487 Disease MiR-487a expression was higher in ECs in the inner curvature (OS region) than the outer curvature of the rat aortic arch and thoracic aorta and also elevated in diseased human coronary arteries. +other 33959608 hsa-mir-487a Disease MiR-487a expression was higher in ECs in the inner curvature (OS region) than the outer curvature of the rat aortic arch and thoracic aorta and also elevated in diseased human coronary arteries. +exosome 33959603 hsa-mir-185 Vascular System Injuries Exosomes derived from miR-185 mimic transfected VSMCs attenuated re-endothelialization after vascular injury. Taken together, our results indicate that exosomal miR-185 transfer from VSMCs to ECs is controlled by hnRNPA2B1 and impairs re-endothelialization after vascular injury. +target gene 33959508 hsa-mir-663a Carcinoma, Hepatocellular Apigenin can inhibit the growth of HCC cells, which may be mediated by up-regulation or down-regulation of miRNA molecules. most significantly up-regulated miRNAs +target gene 33959508 hsa-mir-6089 Carcinoma, Hepatocellular Apigenin can inhibit the growth of HCC cells, which may be mediated by up-regulation or down-regulation of miRNA molecules. most significantly up-regulated miRNAs +target gene 33959508 hsa-mir-181a Carcinoma, Hepatocellular Apigenin can inhibit the growth of HCC cells, which may be mediated by up-regulation or down-regulation of miRNA molecules. most significantly down-regulated miRNAs +target gene 33959508 hsa-mir-4739 Carcinoma, Hepatocellular Apigenin can inhibit the growth of HCC cells, which may be mediated by up-regulation or down-regulation of miRNA molecules. most significantly up-regulated miRNAs +target gene 33959508 hsa-mir-6769b Carcinoma, Hepatocellular Apigenin can inhibit the growth of HCC cells, which may be mediated by up-regulation or down-regulation of miRNA molecules. most significantly up-regulated miRNAs +target gene 33959508 hsa-mir-6892 Carcinoma, Hepatocellular Apigenin can inhibit the growth of HCC cells, which may be mediated by up-regulation or down-regulation of miRNA molecules. most significantly up-regulated miRNAs +target gene 33959508 hsa-mir-7107 Carcinoma, Hepatocellular Apigenin can inhibit the growth of HCC cells, which may be mediated by up-regulation or down-regulation of miRNA molecules. most significantly up-regulated miRNAs +target gene 33959508 hsa-mir-199a Carcinoma, Hepatocellular Apigenin can inhibit the growth of HCC cells, which may be mediated by up-regulation or down-regulation of miRNA molecules. most significantly up-regulated miRNAs +target gene 33959508 hsa-mir-1273g Carcinoma, Hepatocellular Apigenin can inhibit the growth of HCC cells, which may be mediated by up-regulation or down-regulation of miRNA molecules. most significantly up-regulated miRNAs +target gene 33959508 hsa-mir-6836 Carcinoma, Hepatocellular Apigenin can inhibit the growth of HCC cells, which may be mediated by up-regulation or down-regulation of miRNA molecules. most significantly up-regulated miRNAs +target gene 33959508 hsa-mir-148a Carcinoma, Hepatocellular Apigenin can inhibit the growth of HCC cells, which may be mediated by up-regulation or down-regulation of miRNA molecules. most significantly down-regulated miRNAs +target gene 33959508 hsa-mir-1343 Carcinoma, Hepatocellular Apigenin can inhibit the growth of HCC cells, which may be mediated by up-regulation or down-regulation of miRNA molecules. most significantly up-regulated miRNAs +target gene 33959508 hsa-mir-24 Carcinoma, Hepatocellular Apigenin can inhibit the growth of HCC cells, which may be mediated by up-regulation or down-regulation of miRNA molecules. most significantly up-regulated miRNAs +target gene 33959160 hsa-mir-182 Liver Neoplasms mir-182-5p Regulates Cell Growth of Liver Cancer via Targeting RCAN1. +target gene 33958878 hsa-mir-7 Osteosarcoma Downregulation of TAF9B by miR-7-5p Inhibits the Progression of Osteosarcoma. +genetics_overexpression_promote 33958865 hsa-mir-195 Reperfusion Injury, Cerebral Ischemia CONCLUSION: Overexpression of miR +lncRNA target 33958720 hsa-mir-200a Stomach Neoplasms The expression of miR-200a was downregulated in human GC, correlating with upregulation of a novel miR-200a-targeting long non-coding RNA (LncRNA), PINK1 (PTEN Induced Kinase 1)-AS. +genetics_overexpression_suppress 33958701 hsa-mir-150 Colonic Neoplasms 3p and/or SLCO4A1 were overexpressed or depleted in colon cancer cells to detect their effects on migration, invasion, sphere formation, apoptosis and tumorigenesis abilities of colon cancer stem CD133(+)CD44(+) cells using both in vitro and in vivo assays. +transcription factor target 33958654 hsa-mir-132 Epilepsy Interestingly, the miRNA profile in the acute stage of infantile-onset TLE overlaps in dysregulation of miR +lncRNA target 33958547 hsa-mir-4787 Polycystic Kidney Diseases In addition, polycystic kidney disease 1 gene, which encodes polycystin-1 (PC1), was found to be a direct target of miR +other 33958547 hsa-mir-4787 Alzheimer Disease 5p/polycystic kidney disease 1 axis in AD pathobiology. +genetics_knock down_promote 33958507 hsa-mir-217 Stomach Neoplasms Moreover, circ_0000144 sponged miR-217, and rescue assays revealed that silencing miR-217 expression reversed the inhibitory effect of circ_0000144 knockdown on the progress of GC. Our findings reveal that circ_0000144 inhibition suppresses GC cell proliferation, migration and invasion via absorbing miR-217, providing a new biomarker and potential therapeutic target for treatment of GC. +other 33957967 hsa-mir-155 Behcet Syndrome BACKGROUND: Earlier, we reported that the microRNA (miR)-155 expression in dendritic cells (DCs) from Behcet's disease (BD) patients was decreased and affected cytokine production of DCs. +target gene 33957921 hsa-mir-595 Esophageal Squamous Cell Carcinoma circ_NRIP1 is oncogenic in malignant development of esophageal squamous cell carcinoma (ESCC) via miR-595/SEMA4D axis and PI3K/AKT pathway. +lncRNA target 33957117 hsa-mir-205 Stomach Neoplasms 5p suppresses angiogenesis in GC by attenuating the expression of VEGFA and FGF1, indicating that upregulation of miR +genetics_overexpression_promote 33956530 hsa-mir-4709 Breast Neoplasms 3p mimic greatly inhibited the proliferation of breast cancer cells, whereas overexpression of miR +circulation_biomarker_diagnosis_ns 33956301 hsa-mir-145 Colorectal Neoplasms 5p and NRAS, confirmed with ROC curve analysis, these biomarkers may be useful in the screening and differentiating between tumor and control sample in colorectal neoplasm. +genetics_knock down_promote 33956079 hsa-mir-378c Wilms Tumor In addition, xenograft assay showed that miR-378c overexpression inhibited Wilms tumor development in vivo. +other 33956002 hsa-mir-200a Ovarian Neoplasms In the present study, a label-free electrochemical genosensor was designed based on ZnS quantum dots functionalized with l-cysteine (Cys-ZnS-QDs) to detect miR-200a, as a special ovarian cancer biomarker. +other 33955831 hsa-mir-601 Carcinoma, Hepatocellular These results revealed lncRNA PP7080 effect in regulating miR-601/SIRT1 signal axis in the progression of HCC, indicating the important role of miR-601 in HCC pathogenesis. +transcription factor target 33955799 hsa-mir-133a Carcinoma, Non-Small-Cell Lung In conclusion, miR-1/133a and miR-206/133b clusters are able to exhibit the synergetic effect on overcoming HGF-induced gefitinib resistance in NSCLC and the mechanisms are through targeting multiple genes related to gefitinib resistance. +transcription factor target 33955799 hsa-mir-206 Carcinoma, Non-Small-Cell Lung In conclusion, miR-1/133a and miR-206/133b clusters are able to exhibit the synergetic effect on overcoming HGF-induced gefitinib resistance in NSCLC and the mechanisms are through targeting multiple genes related to gefitinib resistance. +transcription factor target 33955799 hsa-mir-1 Carcinoma, Non-Small-Cell Lung In conclusion, miR-1/133a and miR-206/133b clusters are able to exhibit the synergetic effect on overcoming HGF-induced gefitinib resistance in NSCLC and the mechanisms are through targeting multiple genes related to gefitinib resistance. +transcription factor target 33955520 hsa-mir-101 Rift Valley Fever On the whole, the present study demonstrates that miR101 is capable of inhibiting TGFbeta1induced tubular EMT by targeting TbetaRI, suggesting that it may be an important regulator of RIF. +other 33955520 hsa-mir-101 Fibrosis Bioinformatics analyses revealed that miR101 was the miRNA that was most significantly downregulated in the fibrotic renal tissue samples, and this was confirmed by RTqPCR, which also demonstrated that this miRNA was downregulated in transforming growth factor (TGF)beta1treated human proximal tubular epithelial (HK2) cells. +other 33955520 hsa-mir-101 Kidney Diseases Bioinformatics analyses revealed that miR101 was the miRNA that was most significantly downregulated in the fibrotic renal tissue samples, and this was confirmed by RTqPCR, which also demonstrated that this miRNA was downregulated in transforming growth factor (TGF)beta1treated human proximal tubular epithelial (HK2) cells. +lncRNA target 33955515 hsa-mir-93 Cerebral Hemorrhage The present findings provided evidence to support miR935p as a potential therapeutic target for the treatment of ICH. +circulation_biomarker_diagnosis_ns 33955511 hsa-mir-135a Non-alcoholic Fatty Liver Disease In summary, circulating miR135a3p in EVs may serve as a potential noninvasive biomarker to diagnose NAFLD. +genetics_knock down_promote 33955508 hsa-mir-221 Influenza, Human Furthermore, knockdown of SOCS1 efficiently abrogated the influences caused by miR221 inhibition on IAV replication and the typeI IFN response. +lncRNA target 33955505 hsa-mir-486 Mesothelioma On the whole, the present study demonstrates that miR4865p may play an important role in MPM treatment by targeting multiple pathways involved in tumour development and progression. +lncRNA target 33955501 hsa-mir-129 Ovarian Neoplasms These results indicated that HE4 promotes Pgpmediated drug resistance in ovarian cancer cells through the interactions with ANXA2, and the underlying mechanism may be associated with decreased expression of hsamiR1295p and dysregulation of the actin cytoskeleton signaling pathway. +lncRNA target 33955459 hsa-mir-543 Periodontitis 3p could down-regulate inflammation and inhibit periodontitis by targeting KLF6, and it provides a new insight into the molecular mechanism of periodontitis, which may be helpful for the early diagnosis and treatment of this disease. +lncRNA target 33955458 hsa-mir-21 Pulmonary Fibrosis Our findings suggest that in addition to suppressing inflammation, the AM-RAMP2 system ameliorates pulmonary fibrosis by suppressing TGF-beta-Smad3 signaling, microRNA-21 activity and differentiation into non-p-MyoFbs. +lncRNA target 33955315 hsa-mir-340 Lung Neoplasms 5p/NET1 axis, suggesting a new approach to lung cancer clinical management. +other 33955243 hsa-mir-142 Bone Diseases The regulatory roles of miR3p/HMGB1 in some orthopedic diseases have been determined successively, but there was no report about the degeneration of CEP. +other 33955243 hsa-mir-142 Neurodegenerative Diseases The regulatory roles of miR3p/HMGB1 in some orthopedic diseases have been determined successively, but there was no report about the degeneration of CEP. +genetics_knock down_promote 33955122 hsa-mir-373 Choriocarcinoma 3p overexpression inhibited the migration by transwell methods of choriocarcinoma cells. +other 33954256 hsa-mir-495 Carcinoma, Renal Cell In conclusion, down-regulation of circTLK1 restrained proliferation and metastasis and promoted apoptosis in RCC cells by modulating miR3p/CBL axis. +lncRNA target 33954190 hsa-mir-381 Cervical Intraepithelial Neoplasia 3p) that could be used as biomarkers for CIN 3 in LBC samples through multiple logistic regression analyses. +lncRNA target 33954190 hsa-mir-130a Cervical Intraepithelial Neoplasia 3p) that could be used as biomarkers for CIN 3 in LBC samples through multiple logistic regression analyses. +lncRNA target 33954190 hsa-mir-4531 Cervical Intraepithelial Neoplasia 3p) that could be used as biomarkers for CIN 3 in LBC samples through multiple logistic regression analyses. +lncRNA target 33954190 hsa-mir-205 Cervical Intraepithelial Neoplasia 3p) that could be used as biomarkers for CIN 3 in LBC samples through multiple logistic regression analyses. +lncRNA target 33954185 hsa-mir-497 Acute Lung Injury 5p reduced ALI caused by sepsis through targeting IL2RB, indicating the potential effect of miR +lncRNA target 33954185 hsa-mir-497 Sepsis 5p reduced ALI caused by sepsis through targeting IL2RB, indicating the potential effect of miR +transcription factor target 33953853 hsa-mir-486a Diabetic Cardiomyopathies Bioinformatic analysis and apoptosis assessments revealed exercise exerted protective effects against DCM through miR-486a-5p release. CONCLUSION: Physical exercise inhibits cardiac remodelling in DCM, and the mechanism is associated with miR-486a-5p release-induced Mst1 inhibition. +exosome 33953745 hsa-mir-130a Squamous Cell Carcinoma of Head and Neck Our results suggest that exosomal miR-130a may serve as a promising diagnostic and prognostic biomarker for OSCC patients. +target gene 33953744 hsa-mir-139 Leukemia, Promyelocytic, Acute miR-139-5p Regulates the Proliferation of Acute Promyelocytic Leukemia Cells by Targeting MNT. +other 33953665 hsa-mir-4456 Pulmonary Disease, Chronic Obstructive miR-4456/CCL3/CCR5 Pathway in the Pathogenesis of Tight Junction Impairment in Chronic Obstructive Pulmonary Disease. +other 33953608 hsa-mir-182 Carcinoma, Non-Small-Cell Lung 5p may play an oncogenic role in NSCLC. +lncRNA target 33953608 hsa-mir-183 Carcinoma, Non-Small-Cell Lung 3p could be used as a potential prognostic biomarker and therapeutic target to manage lung cancer. +therapeutic target 33953601 hsa-mir-195 Carcinoma, Non-Small-Cell Lung Reversal of Chemotherapy Resistance to Cisplatin in NSCLC by miRNA-195-5p via Targeting the FGF2 Gene. +genetics_overexpression_promote 33953572 hsa-mir-140 Stomach Neoplasms Moreover, we noticed that overexpression or downregulation of miR +lncRNA target 33953571 hsa-mir-211 Rectal Neoplasms CONCLUSION: Down-regulation of EGOT could inhibit the growth of rectal cancer cells by regulating the miR +other 33953570 hsa-mir-140 Uterine Cervical Neoplasms TCEB3 is Regulated by Circ-0000212/miR-140-3p Axis to Promote the Progression of Cervical Cancer. +other 33953222 hsa-mir-126 Colonic Neoplasms High expression of miR-126 is an independent positive prognostic factor in stage I-III colon cancer. +lncRNA target 33953168 hsa-mir-23a Sjogren's Syndrome We demonstrate that miRNA-30a and miRNA-23a, increased in SM-EVs and neoplastic mast cell-derived EVs, attenuate osteoblast maturation by suppressing expression of RUNX2 and SMAD1/5, essential drivers of osteogenesis. +genetics_overexpression_promote 33952723 hsa-mir-142 Choroidal Neovascularization 3p was overexpressed in murine CNV lesions and its pharmacological inhibition decreased vascular and microglia densities by 46% and 30%, respectively. +lncRNA target 33952719 hsa-mir-222 Carcinoma, Hepatocellular In summary, SOX2-mediated HCC progression through an axis involving CCAT1, EGFR, and miR +genetics_overexpression_promote 33952469 hsa-mir-663 Stomach Neoplasms Overexpression of miR +circulation_biomarker_diagnosis_ns 33952466 hsa-mir-93 Hemoglobinuria, Paroxysmal TCGA database analysis showed that miRNA-93 was increased in PC tissue. CONCLUSION: miRNA-93 contained in serum EVs may be a novel diagnostic and monitoring biomarker for PC. +genetics_GWAS 33952417 hsa-mir-210 Breast Neoplasms RESULTS: In the GU-CCQ-BB population, miRSNPs TET2-rs7670522, ESR1-rs2046210, FGFR2-rs1219648, MIR210-rs1062099, HIF1A-rs2057482, and CASC16-rs4784227 were found to be associated with increased BC risk (P . +other 33906322 hsa-mir-92a Uterine Cervical Neoplasms 5p, which are upregulated in LSIL and HSIL, can be consider as predictive biomarkers for the prognosis of cervical cancer patients.
. +other 33906290 hsa-mir-155 Uterine Cervical Neoplasms The pooled HR of two miRNAs, miRNA-155 and miRNA-224 which were upregulated in cervical cancer tissues was 1.76 (95% CI 1.27-2.45) revealing significant association with overall poor survival. +other 33906290 hsa-mir-224 Uterine Cervical Neoplasms The pooled HR of two miRNAs, miRNA-155 and miRNA-224 which were upregulated in cervical cancer tissues was 1.76 (95% CI 1.27-2.45) revealing significant association with overall poor survival. +lncRNA target 33906109 hsa-mir-21 Drug Hypersensitivity In this study, we report the application of an RNA nanotechnology-based platform for the targeted delivery of anti-miR-21 by epidermal growth factor receptor (EGFR) aptamer in vitro to TNBC and chemical-resistant breast cancer cells. +lncRNA target 33906109 hsa-mir-21 Breast Neoplasms An oncogenic miRNA, miR-21, is highly expressed in triple-negative breast cancer (TNBC) and is associated with tumor proliferation, invasion, carcinogenesis, prognosis, and therapeutic resistance. In this study, we report the application of an RNA nanotechnology-based platform for the targeted delivery of anti-miR-21 by epidermal growth factor receptor (EGFR) aptamer in vitro to TNBC and chemical-resistant breast cancer cells. +lncRNA target 33906109 hsa-mir-21 Triple Negative Breast Neoplasms Inhibition of miR-21 by RNA nanoparticles suppressed TNBC cell invasion, migration, and colony formation. +transcription factor target 33905870 hsa-mir-145 Pulmonary Disease, Chronic Obstructive In summary, isoxanthanol prevents Staphylococcus aureus-induced COPD in rats through up-regulation of miR5p and suppression of inflammatory cytokines. +circulation_biomarker_diagnosis_ns 33905821 hsa-mir-208b Colorectal Neoplasms We demonstrated that circulating miR-208b is a non-invasive marker for predicting FOLFOX sensitivity in CRC. Our results demonstrate that tumor-secreted miR-208b promotes Treg expansion by targeting PDCD4, and it may be related to a decrease of oxaliplatin-based chemosensitivity in CRC. +transcription factor target 33905668 hsa-mir-92a Cerebrovascular Disorders CONCLUSIONS: These findings suggest that alisol A 24-acetate exerts antiapoptotic effects on OGD-induced BMECs through miR-92a-3p inhibition by targeting the Bcl-2 gene, indicating its potential for BMECs protection and as a novel therapeutic agent for the treatment of cerebrovascular disease. +circulation_biomarker_diagnosis_ns 33905318 hsa-mir-142 Spinal Injuries 5p and serum levels of IL-6, TNF-alpha in SCI patients. +circulation_biomarker_diagnosis_ns 33905318 hsa-mir-142 Spinal Cord Injuries 5p and serum levels of IL-6, TNF-alpha in SCI patients. +lncRNA target 33904680 hsa-mir-34a Breast Neoplasms Due to the properties of CM, this study assesses the effects of miR-34a related MSC-CM on tumor behavior through the evaluation of migration, invasion, apoptosis, and PDL1 expression in breast cancer cell lines. The results of the present study showed that simultaneous application of miR-34a and MSC-CM can be considered as a new method for changing the cancerous microenvironment; and therefore, as a potential strategy in breast cancer therapy. +transcription factor target 33904674 hsa-mir-223 Asthma Based on our findings,miR-223 and miR-21 may be considered biomarkers or used for targeted immunotherapies in asthma. +transcription factor target 33904674 hsa-mir-21 Asthma Based on our findings,miR-223 and miR-21 may be considered biomarkers or used for targeted immunotherapies in asthma. +circulation_biomarker_diagnosis_ns 33904657 hsa-mir-519a Inflammatory Bowel Diseases There was no significant difference in the expression of miR-519a in the blood samples of UC and HC. +genetics_overexpression_promote 33904383 hsa-mir-140 Intervertebral Disc Degeneration 3p was under-expressed in the degenerated IVD NP, whereas its overexpression alleviated IDD. +genetics_overexpression_suppress 33904366 hsa-mir-181a Osteoporosis-pseudoglioma syndrome Our data also indicated that miR-181a-5p overexpression significantly inhibited ALP activity, and level of OPN, Runx2 and OCN at mRNA and protein level, whereas miR-181a-5p inhibition presented opposite results. +genetics_knock down_suppress 33904112 hsa-mir-424 Acute Lung Injury CONCLUSION: NEAT1 knockdown alleviated LPS-induced injury of HPAEpiCs by regulating miR5p/MAPK14 axis, which provided a potential therapeutic target for the treatment of ALI. +lncRNA target 33903887 hsa-mir-126 Reperfusion Injury, Hepatic Ischemia The results suggest that Dex protects hepatocytes from HIRI via regulating MALAT1/miR +lncRNA target 33903707 hsa-let-7a Obesity, Maternal The transfection of Let-7a inhibitor in ex-vivo liver slices from the offspring of obese dams restored phospho-AMPKalpha2 levels. +other 33903707 hsa-let-7 Obesity, Maternal In summary, Let-7a appears to regulate hepatic AMPKalpha2 protein levels and lead to the early hepatic metabolic disturbances in the offspring of obese dams. +genetics_overexpression_promote 33902659 hsa-mir-125b Aneuploidy CONCLUSION: These results suggest that aneuploid abortion correlates positively with MAD1 overexpression, which might be caused by insufficient levels of miR-125b. +lncRNA target 33902658 hsa-mir-3074 Triple Negative Breast Neoplasms Our results suggest that the inhibition of RARalphaS77 phosphorylation by either expressing RARalphaS77A or inhibiting RARalpha's phosphokinase CDK7, can bypass RA stimuli to transactivate tumor-suppressive miR +target gene 33902604 hsa-mir-188 Breast Neoplasms lncRNA APOC1P1-3 promoting anoikis-resistance of breast cancer cells by specifically binding to miRNA-188-3p to block the inhibition of Bcl-2. +genetics_knock down_suppress 33902591 hsa-mir-432 Carcinoma, Non-Small-Cell Lung 5p depletion offset the impacts of LINC01783 knockdown, and then DLL-1 silence recovered the influence of miR +other 33902589 hsa-mir-655 Urinary Bladder Neoplasms The VIM-AS1/miR-655/ZEB1 axis modulates bladder cancer cell metastasis by regulating epithelial-mesenchymal transition. +transcription factor target 33902432 hsa-mir-27a Osteoporosis It was reported that miR-27a-3p reduced the symptoms of osteoporosis. Thereby, miR-27a-3p might serve as a new target for the treatment of osteoporosis. +other 33902338 hsa-mir-200c Exocrine Pancreatic Insufficiency Participants with exocrine insufficiency had lower hsa-miR-29b-3p, hsa-miR-148a-3p, hsa-miR-320d, hsa-miR3p (P < 0.01) and hsa-miR-375, hsa-miR-200c-3p, and hsa-miR-125b-5p (P < 0.05). +other 33902338 hsa-mir-7 Metabolic Diseases Levels of hsa-miR-148a-3p (P = 0.04) and hsa-miR5p (P = 0.04) were elevated in toxic/metabolic disease. +other 33902338 hsa-mir-221 Exocrine Pancreatic Insufficiency Participants with exocrine insufficiency had lower hsa-miR-29b-3p, hsa-miR-148a-3p, hsa-miR-320d, hsa-miR3p (P < 0.01) and hsa-miR-375, hsa-miR-200c-3p, and hsa-miR-125b-5p (P < 0.05). +other 33902338 hsa-mir-148a Metabolic Diseases Levels of hsa-miR-148a-3p (P = 0.04) and hsa-miR5p (P = 0.04) were elevated in toxic/metabolic disease. +other 33902338 hsa-mir-29b Exocrine Pancreatic Insufficiency Participants with exocrine insufficiency had lower hsa-miR-29b-3p, hsa-miR-148a-3p, hsa-miR-320d, hsa-miR3p (P < 0.01) and hsa-miR-375, hsa-miR-200c-3p, and hsa-miR-125b-5p (P < 0.05). +other 33902338 hsa-mir-148a Exocrine Pancreatic Insufficiency Participants with exocrine insufficiency had lower hsa-miR-29b-3p, hsa-miR-148a-3p, hsa-miR-320d, hsa-miR3p (P < 0.01) and hsa-miR-375, hsa-miR-200c-3p, and hsa-miR-125b-5p (P < 0.05). +other 33902338 hsa-mir-320d Exocrine Pancreatic Insufficiency Participants with exocrine insufficiency had lower hsa-miR-29b-3p, hsa-miR-148a-3p, hsa-miR-320d, hsa-miR3p (P < 0.01) and hsa-miR-375, hsa-miR-200c-3p, and hsa-miR-125b-5p (P < 0.05). +other 33902338 hsa-mir-375 Exocrine Pancreatic Insufficiency Participants with exocrine insufficiency had lower hsa-miR-29b-3p, hsa-miR-148a-3p, hsa-miR-320d, hsa-miR3p (P < 0.01) and hsa-miR-375, hsa-miR-200c-3p, and hsa-miR-125b-5p (P < 0.05). +other 33902338 hsa-mir-125b Exocrine Pancreatic Insufficiency Participants with exocrine insufficiency had lower hsa-miR-29b-3p, hsa-miR-148a-3p, hsa-miR-320d, hsa-miR3p (P < 0.01) and hsa-miR-375, hsa-miR-200c-3p, and hsa-miR-125b-5p (P < 0.05). +lncRNA target 33902331 hsa-mir-199a Lung Neoplasms PVT1 absorbed miR-199a, and miR-199a inhibited caveolin1 expression and thus formed the PVT1/miR-199a/caveolin1 signaling pathway in lung cancer cells. Our study revealed that silencing of the PVT1/miR-199a/caveolin1 signaling pathway affected the role of lentinan in PM2.5-exposed lung cancer cells. +lncRNA target 33902208 hsa-mir-490 Osteosarcoma Conclusion: Circ_0006948 regulates ATG7 expression through miR +circRNA target 33902207 hsa-mir-217 Colorectal Neoplasms Conclusion: Silence of circABCB10 can up-regulate the expression of miR-217 to inhibit the proliferation, migration, invasion and growth of subcutaneous xenografts and increase the radiosensitivity of SW480 cells, which reveals the underlying molecular mechanism of colorectal cancer progression and provides a new sensitizing target for clinical radiotherapy of colorectal cancer. +other 33902008 hsa-mir-495 Breast Neoplasms Combination of the results from expression, survival, correlation analysis and functional experiments analysis demonstrated the link between lncRNA GATA3-AS1/miR3p/CENPU axis and prognosis of breast cancer. +transcription factor target 33901943 hsa-mir-622 Carcinoma, Hepatocellular Moreover, the cooperator of LIN28A, ZCCHC11, was newly identified as a prognostic and therapeutic target of miR-622 in liver cancer. Together, identification of novel miR-622 target genes revealed common regulation of cooperating genes and outlines the previously unknown oncogenic role of ZCCHC11 in liver cancer. +circulation_biomarker_diagnosis_ns 33901926 hsa-mir-335 Diabetes Mellitus, Type 2 5p and decreased SLC2A4 expression was observed in both T2D blood samples and pancreatic cell lines. +circulation_biomarker_diagnosis_down 33901624 hsa-mir-409 Diabetes Mellitus RESULTS: Hsa_circ_0054633 was highly expressed and the expression of miR3p was downregulated in serum of DM patients and HG-treated human pancreatic beta cell line NES2Y. +lncRNA target 33901578 hsa-mir-1301 Carcinoma, Renal Cell In conclusions, SNHG16 promotes ccRCC cell proliferation and suppresses ccRCC cell apoptosis via interaction with miR +genetics_knock down_promote 33901298 hsa-mir-204 Squamous Cell Carcinoma of Head and Neck 5p overexpression markedly inhibited ESCC cell growth, migration and invasion (P < .05). +transcription factor target 33901269 hsa-mir-34a Intracranial Aneurysm In conclusion, miR-34a is down-regulated in IAs while CXCR3 is the direct target of miR-34a that regulates phenotypic modulation of VSMCs. +circulation_biomarker_diagnosis_up 33901254 hsa-let-7a Inflammatory Breast Neoplasms Together, circulating sEV-derived miR-181b-5p, miR +circulation_biomarker_diagnosis_up 33901254 hsa-mir-222 Inflammatory Breast Neoplasms Together, circulating sEV-derived miR-181b-5p, miR +lncRNA target 33901015 hsa-mir-139 Liver Failure In conclusion, silencing lncRNA NEAT1 upregulated the expression of miR-139 through EZH2, leading to the downregulation of PUMA, which alleviated the development of ALF. +other 33901010 hsa-mir-1297 Glioma Glioma progression appears to be supported DLGAP1-AS1 -promoted activation of the miR-1297/EZH2 axis. +lncRNA target 33901009 hsa-mir-107 Carcinoma, Hepatocellular Our findings demonstrated that miR-107 downregulation leads to hepatocellular carcinoma cell resistance in HDACi via a cofilindependent molecular mechanism and ROS accumulation. +other 33900636 hsa-mir-34c Testicular Diseases In this study, we aimed to evaluate the effects of CP-induced testicular toxicity, using glial cell line-derived neurotrophic factor (GDNF), occludin and transforming growth factor beta 3 (TGF-beta3) primary antibodies, and miR-34b and miR-34c expressions. +other 33900636 hsa-mir-34c isolated cleft palate In this study, we aimed to evaluate the effects of CP-induced testicular toxicity, using glial cell line-derived neurotrophic factor (GDNF), occludin and transforming growth factor beta 3 (TGF-beta3) primary antibodies, and miR-34b and miR-34c expressions. The expressions of miR-34b and miR-34c were examined by qPCR technique, a significant decrease was observed in tissue samples in the CP-treated group. +other 33900636 hsa-mir-34b Testicular Diseases In this study, we aimed to evaluate the effects of CP-induced testicular toxicity, using glial cell line-derived neurotrophic factor (GDNF), occludin and transforming growth factor beta 3 (TGF-beta3) primary antibodies, and miR-34b and miR-34c expressions. The expression of GDNF, occludin and TGF-beta3 plays an important role in testicular injury caused by CP, and the decrease in the expression of miR-34b/c in tissue samples may be an important marker for the detection of testicular damage. +other 33900636 hsa-mir-34b isolated cleft palate The expression of GDNF, occludin and TGF-beta3 plays an important role in testicular injury caused by CP, and the decrease in the expression of miR-34b/c in tissue samples may be an important marker for the detection of testicular damage. +circulation_biomarker_diagnosis_ns 33900534 hsa-mir-124a Brain Injuries Circulating miRNA-124a is a potential biomarker for the appearance of neurological deficits in pediatric patients following heart surgery. +circulation_biomarker_diagnosis_ns 33900534 hsa-mir-124a Heart Diseases Circulating miRNA-124a is a potential biomarker for the appearance of neurological deficits in pediatric patients following heart surgery. +other 33900518 hsa-mir-93 Parkinson Disease This study aimed at investigating the role of miR-93 in PD and the molecular mechanisms involved. In conclusion, we demonstrate that miR-93 may be involved in PD by regulating the expression of STAT3. +genetics_GWAS 33900350 hsa-mir-483 Carcinoma, Hepatocellular The data from our study illustrate that miR483-3p promotes HCC metastasis likely through the induction of oxidative stress and uncover a novel role of EGCG for protection against miR483-3p-mediated HCC metastasis via the epigenetic modulation of miR483-3p expression. +lncRNA target 33899983 hsa-mir-126 Axenfeld-Rieger syndrome 5p expression, as well as indirectly inhibiting the expression of VEGFA. +other 33899508 hsa-mir-4721 Hyperlipoproteinemia Type II miR-4721 and miR-564 downregulate PCSK9 and may be useful to improve lipid profile in FH patients. +other 33899508 hsa-mir-564 Hyperlipoproteinemia Type II miR-4721 and miR-564 downregulate PCSK9 and may be useful to improve lipid profile in FH patients. +other 33899115 hsa-mir-106b Esophageal Neoplasms The results revealed that miR106b3p levels were upregulated, whereas TMG3 levels were downregulated in ESCC tissues. +lncRNA target 33899079 hsa-mir-506 Stomach Neoplasms In conclusion, our findings revealed that SNHG15 executed oncogenic properties in GC progression through targeting miR5p, which might provide a novel target for the GC treatment. +other 33898875 hsa-mir-122 Carcinoma, Hepatocellular Moreover, sCDP/DOX/miR-122 displays remarkably increased anti-tumor efficacy in vivo compared to free DOX and sCDP/DOX alone, indicating its great promising in hepatoma therapy. +exosome 33898768 hsa-mir-33a Colorectal Neoplasms miR-33a-5p in small extracellular vesicles as non-invasive biomarker for oxaliplatin sensitivity in human colorectal cancer cells. +genetics_overexpression_suppress 33898511 hsa-mir-490 Colonic Neoplasms However, without overexpression of miRISC components, when treating CC cells with 1,6-hexanediol(1,6-HD), a widely used LLPS inhibitor, the silence effects of miR +genetics_knock down_promote 33898469 hsa-mir-155 Murine Acquired Immunodeficiency Syndrome miR-155 overexpression also increased CD4(-)CD8(+) subset and decreased CD4(-)CD8(-) subset of MAIT cells. +target gene 33898446 hsa-mir-143 bladder carcinoma LINC00511/miRNA-143-3p Modulates Apoptosis and Malignant Phenotype of Bladder Carcinoma Cells via PCMT1. +transcription factor target 33898415 hsa-mir-155 Cardiomegaly In conclusion, our data suggest that MKL1 may contribute to pathological hypertrophy via regulating macrophage-derived miR-155 transcription. +exosome 33898323 hsa-mir-494 Carcinoma, Non-Small-Cell Lung Targeting c-Jun in A549 Cancer Cells Exhibits Antiangiogenic Activity In Vitro and In Vivo Through Exosome/miRNA-494-3p/PTEN Signal Pathway. +exosome 33898109 hsa-mir-181a Thyroid Cancer, Papillary In conclusion, exosomal miR-181a from hypoxic PTC cells promotes tumor angiogenesis and growth through MLL3 and DACT2 downregulation, as well as VEGF upregulation. +target gene 33898107 hsa-mir-2355 Pancreatic Neoplasms TRIM29 alters bioenergetics of pancreatic cancer cells via cooperation of miR-2355-3p and DDX3X recruitment to AK4 transcript. +target gene 33898105 hsa-mir-20b Lung Neoplasms Intermittent hypoxia-induced downregulation of microRNA-320b promotes lung cancer tumorigenesis by increasing CDT1 via USP37. +other 33897883 hsa-mir-146b Abortion, Habitual Clinically, expression of miR-146a-5p, miR-146b-5p, and TRAF6 were aberrant in placental villous tissues from patients with RSA, and negative correlations were found between miR-146a-5p/miR-146b-5p and TRAF6 expression levels. Conclusions: Our findings indicate that miR-146a-5p and miR-146b-5p derived from EVs play important roles in intercellular communication between M1 macrophages and trophoblasts, illuminating a novel mechanism in M1 macrophage regulation of trophoblasts and their role in RSA. +other 33897883 hsa-mir-146a Abortion, Habitual Clinically, expression of miR-146a-5p, miR-146b-5p, and TRAF6 were aberrant in placental villous tissues from patients with RSA, and negative correlations were found between miR-146a-5p/miR-146b-5p and TRAF6 expression levels. Conclusions: Our findings indicate that miR-146a-5p and miR-146b-5p derived from EVs play important roles in intercellular communication between M1 macrophages and trophoblasts, illuminating a novel mechanism in M1 macrophage regulation of trophoblasts and their role in RSA. +other 33897771 hsa-mir-93 Melanoma 5p were obviously regulated positively in metastatic melanoma tissues. +other 33897771 hsa-mir-155 Melanoma 5p were obviously regulated positively in metastatic melanoma tissues. +other 33897771 hsa-mir-18a Melanoma 5p were obviously regulated positively in metastatic melanoma tissues. +transcription factor target 33897713 hsa-mir-486 Arthritis, Rheumatoid Several of the differentially expressed miRNAs were previously found to be dysregulated in RA including miR +transcription factor target 33897713 hsa-mir-223 Arthritis, Rheumatoid Several of the differentially expressed miRNAs were previously found to be dysregulated in RA including miR +transcription factor target 33897713 hsa-mir-23a Arthritis, Rheumatoid Several of the differentially expressed miRNAs were previously found to be dysregulated in RA including miR +circulation_biomarker_diagnosis_ns 33897448 hsa-mir-150 Diabetic Nephropathies 5p were detected in the serum and urine of patients with DN. +circulation_biomarker_diagnosis_ns 33897064 hsa-mir-27b Depression At the same time, correlation analysis didn't reveal a statistically significant relationship between the fluvoxamine efficacy profile evaluated by changes in HAMD scale scores and the miR-27b plasma concentration: r(s) = -0.012, p = 0.63. +circulation_biomarker_diagnosis_ns 33897064 hsa-mir-27b Alcoholism At the same time, correlation analysis didn't reveal a statistically significant relationship between the fluvoxamine efficacy profile evaluated by changes in HAMD scale scores and the miR-27b plasma concentration: r(s) = -0.012, p = 0.63. +lncRNA target 33896835 hsa-mir-1208 Carcinoma, Non-Small-Cell Lung NSCLC cells were transfected with si-PVT1 or miR-1208 inhibitor and then exposed to irradiation. +exosome 33896827 hsa-mir-1468 Carcinoma, Non-Small-Cell Lung Among them, 4 exosomal miRNAs, miR +exosome 33896827 hsa-mir-23 Carcinoma, Non-Small-Cell Lung Among them, 4 exosomal miRNAs, miR +other 33896797 hsa-mir-151 Ovarian Neoplasms In conclusion, this study demonstrated that circ_0007841/miR3p/MEX3C axis exerted important oncogenic functions in ovarian cancer. +circulation_biomarker_diagnosis_ns 33896365 hsa-mir-337 Stomach Neoplasms Thus, our data suggested hsa_circ_0000117 exhibited oncogene properties in combination with the hsa_circ_0000117/miR3p/STAT3 axis in GC, potentially providing a new therapeutic target for GC.Abbreviations GC: gastric cancer; STAT3: Signal transducer and activator of transcription 3; circRNA: Circular RNA; miRNA: microRNA; DMEM: Dulbecco's modified Eagle's medium; FBS: fetal bovine serum; PVDF: polyvinylidene fluoride; CCK-8: Cell counting kit-8; qRT-PCR: Quantitative real-time PCR; SDS-PAGE: sodium dodecyl sulfate polyacrylamide gel electrophoresis; TNM: TNM Classification of Malignant Tumors; mTOR: mechanistic target of rapamycin; ANOVA: one-way analysis of variance. +genetics_overexpression_promote 33896068 hsa-mir-125b Pancreatic Carcinoma Also, overexpression of miR-125b encouraged migration, metastasis, and proliferation of BxPC-3 cells, and suppression reversed it. +circulation_biomarker_prognosis_ns 33895755 hsa-mir-21 Cholecystitis AIM: The aim of this study was to evaluate the efficacy of determining the microRNA-122 and microRNA-21 expression levels in serum and bile as predictors of the presence of oligosymptomatic choledocholithiasis in patients with acute calculous cholecystitis. The probability model of the presence of oligosymptomatic choledocholithiasis in patients with acute calculous cholecystitis using quantitative determination of expression levels of microRNA-122 and microRNA-21 in serum and bile has high prognostic significance and can be recommended for application in clinical protocols of patient examination. +circulation_biomarker_prognosis_ns 33895755 hsa-mir-122 Cholecystitis AIM: The aim of this study was to evaluate the efficacy of determining the microRNA-122 and microRNA-21 expression levels in serum and bile as predictors of the presence of oligosymptomatic choledocholithiasis in patients with acute calculous cholecystitis. The probability model of the presence of oligosymptomatic choledocholithiasis in patients with acute calculous cholecystitis using quantitative determination of expression levels of microRNA-122 and microRNA-21 in serum and bile has high prognostic significance and can be recommended for application in clinical protocols of patient examination. +circulation_biomarker_prognosis_ns 33895755 hsa-mir-122 Choledocholithiasis AIM: The aim of this study was to evaluate the efficacy of determining the microRNA-122 and microRNA-21 expression levels in serum and bile as predictors of the presence of oligosymptomatic choledocholithiasis in patients with acute calculous cholecystitis. The probability model of the presence of oligosymptomatic choledocholithiasis in patients with acute calculous cholecystitis using quantitative determination of expression levels of microRNA-122 and microRNA-21 in serum and bile has high prognostic significance and can be recommended for application in clinical protocols of patient examination. +circulation_biomarker_prognosis_ns 33895755 hsa-mir-21 Choledocholithiasis AIM: The aim of this study was to evaluate the efficacy of determining the microRNA-122 and microRNA-21 expression levels in serum and bile as predictors of the presence of oligosymptomatic choledocholithiasis in patients with acute calculous cholecystitis. The probability model of the presence of oligosymptomatic choledocholithiasis in patients with acute calculous cholecystitis using quantitative determination of expression levels of microRNA-122 and microRNA-21 in serum and bile has high prognostic significance and can be recommended for application in clinical protocols of patient examination. +other 33895495 hsa-mir-345 Lung Neoplasms Collectively, SOX2-OT/microRNA5p/EGFR is a ceRNA mechanism underlying the malignant transformation of bronchial epithelia exposed to PM(2.5), which improves our understanding of the association between ambient PM(2.5) exposure and the development of lung cancer. +circulation_biomarker_diagnosis_up 33895478 hsa-mir-29a COVID-19 5p were evaluated in peripheral blood mononuclear cells (PBMCs) of COVID-19 patients, in both the acute and post-acute COVID-19 phase of the disease and healthy groups, by real-time PCR assays. +lncRNA target 33895168 hsa-mir-424 Colorectal Neoplasms RESULTS: Our analyses of human colorectal cancer immune profiles and tumor-immune cell interactions showed that tumor-secreted EVs containing microRNA miR-424 suppressed the CD28-CD80/86 costimulatory pathway in tumor-infiltrating T cells and dendritic cells, leading to immune checkpoint blockade resistance. Modified tumor-secreted EVs with miR-424 knocked down enhanced T-cell-mediated antitumor immune response in colorectal cancer tumor models and increased the immune checkpoint blockade response. +transcription factor target 33894415 hsa-mir-223 Hyperglycemia Transthyretin (TTR) has been proved to repress neovascularization in diabetic retinopathy environment by regulating the molecules in and downstream of the STAT-4/miR3p/FBXW7 signal pathway; however, the details of its direct targets are still not well understood. +other 33894361 hsa-mir-14 Jaw Abnormalities On the other hand, wing malformation was observed in miR-2 and miR-306 agomirs and miR-2 and miR-14 antagomirs, respectively, suggesting their involvement in S. +other 33894361 hsa-mir-2 Jaw Abnormalities On the other hand, wing malformation was observed in miR-2 and miR-306 agomirs and miR-2 and miR-14 antagomirs, respectively, suggesting their involvement in S. +genetics_knock down_promote 33894312 hsa-mir-34a Stomach Neoplasms Functional gain-and-loss experiments indicated that hsa-miR-34a-5p enhances the chemotherapy sensitivity of MDR GC cells by inhibiting SIRT1, P-gp and MRP1. +lncRNA target 33894272 hsa-mir-34a Ovarian Neoplasms This study was aimed at investigating the effect of oleuropein on cell viability, cisplatin resistance, and apoptosis, as well as the expression levels of miR-34a, miR-125b, miR16, miR-21, and some of their potential target genes in ovarian cancer cells. Moreover, this is the 1st report of a significant decrease in the expression of miR-21 and increase in the expression of miR-34a, miR-125b, and miR16 by oleuropein and/or cisplatin in ovarian cancer cells. +lncRNA target 33894272 hsa-mir-21 Ovarian Neoplasms This study was aimed at investigating the effect of oleuropein on cell viability, cisplatin resistance, and apoptosis, as well as the expression levels of miR-34a, miR-125b, miR16, miR-21, and some of their potential target genes in ovarian cancer cells. Moreover, this is the 1st report of a significant decrease in the expression of miR-21 and increase in the expression of miR-34a, miR-125b, and miR16 by oleuropein and/or cisplatin in ovarian cancer cells. +lncRNA target 33894272 hsa-mir-16 Ovarian Neoplasms This study was aimed at investigating the effect of oleuropein on cell viability, cisplatin resistance, and apoptosis, as well as the expression levels of miR-34a, miR-125b, miR16, miR-21, and some of their potential target genes in ovarian cancer cells. Moreover, this is the 1st report of a significant decrease in the expression of miR-21 and increase in the expression of miR-34a, miR-125b, and miR16 by oleuropein and/or cisplatin in ovarian cancer cells. +lncRNA target 33894272 hsa-mir-125b Ovarian Neoplasms This study was aimed at investigating the effect of oleuropein on cell viability, cisplatin resistance, and apoptosis, as well as the expression levels of miR-34a, miR-125b, miR16, miR-21, and some of their potential target genes in ovarian cancer cells. Moreover, this is the 1st report of a significant decrease in the expression of miR-21 and increase in the expression of miR-34a, miR-125b, and miR16 by oleuropein and/or cisplatin in ovarian cancer cells. +circRNA target 33894003 hsa-mir-195 Squamous Cell Carcinoma of Head and Neck Taken together, propofol regulated aggressive progression of OSCC via the circ_0005623/miR +lncRNA target 33893997 hsa-mir-124 Prostatic Neoplasms 3p suppressed cell viability, proliferation, migration, invasion and enhanced apoptosis of prostatic carcinoma cells by directly sponging PTGS2 to inhibit the AKT/NF-kappaB pathway. +genetics_overexpression_promote 33893298 hsa-mir-146a Colorectal Neoplasms MiR-146a overexpression or miR-146a target inhibition represent therapeutic approaches that limit pathways converging on tumorigenic IL-17 signaling in CRC. +circulation_biomarker_diagnosis_ns 33893248 hsa-mir-202 Reperfusion Injury, Cerebral Ischemia 3p on CIRI, angiogenesis in midbrain tissue, and the release of inflammatory factors (IFs) in the serum were measured using in vivo rat models. +genetics_knock down_promote 33893245 hsa-mir-1246 Leukemia Then, gain- and loss-of-function assays were performed in LSCs, where LSCs were co-cultured with AML cell-derived EVs to characterize the effects of miR +genetics_knock down_promote 33893245 hsa-mir-1246 Leukemia, Myeloid, Acute Then, gain- and loss-of-function assays were performed in LSCs, where LSCs were co-cultured with AML cell-derived EVs to characterize the effects of miR +transcription factor target 33893086 hsa-mir-181c Medulloblastoma RESULTS: Compared to the PTCH1 tumor, the SUFU tumor demonstrated lower expression of miR-301a-3p and miR-181c-5p, matrix metallopeptidase 11 (MMP11) and OTX2, higher expression of miR5p and corresponding lower expression of its targeted gene, connexin 30 (GJB6). +circulation_biomarker_diagnosis_ns 33893078 hsa-mir-4525 Carcinoma, Renal Cell Among them, miRNA-4525 was significantly elevated; miRNA-4525 expression was higher in RCC tissue than in the adjacent normal tissue. CONCLUSION: These findings suggest the potential of miRNA-4525 in serum EVs as a novel biomarker for advanced RCC. +other 33893074 hsa-mir-139 Prostatic Neoplasms CONCLUSION: miR-139 acts as an immune agonist of RIG-1 to enhance IFN-beta response in prostate cancer cells. +circulation_biomarker_diagnosis_ns 33893071 hsa-mir-222 Pancreatic Carcinoma miR-34a-5p [AUC = 0.77; 95% confidence interval (CI), 0.66-0.87], miR-130a-3p (AUC = 0.74; 95% CI, 0.63-0.84), and miR3p (AUC = 0.70; 95% CI, 0.58-0.81) were identified as significantly differentially abundant in plasma from stage II PDAC versus controls. +circulation_biomarker_diagnosis_ns 33893071 hsa-mir-130a Pancreatic Carcinoma miR-34a-5p [AUC = 0.77; 95% confidence interval (CI), 0.66-0.87], miR-130a-3p (AUC = 0.74; 95% CI, 0.63-0.84), and miR3p (AUC = 0.70; 95% CI, 0.58-0.81) were identified as significantly differentially abundant in plasma from stage II PDAC versus controls. +circulation_biomarker_diagnosis_ns 33893071 hsa-mir-34a Pancreatic Carcinoma miR-34a-5p [AUC = 0.77; 95% confidence interval (CI), 0.66-0.87], miR-130a-3p (AUC = 0.74; 95% CI, 0.63-0.84), and miR3p (AUC = 0.70; 95% CI, 0.58-0.81) were identified as significantly differentially abundant in plasma from stage II PDAC versus controls. +lncRNA target 33892661 hsa-mir-196a Stomach Neoplasms CONCLUSION: In conclusion, this research supported the first evidence that FGD5-AS1 suppressed proliferation and metastasis in gastric cancer by regulating miR-196a-5p/SMAD6/BMP axis and suggested a potential therapeutic candidate for gastric cancer. +lncRNA target 33892399 hsa-mir-543 Adenocarcinoma of Lung LINC01089 inhibited lung adenocarcinoma cell proliferation and promoted apoptosis via sponging miR-543. +other 33892093 hsa-mir-7 Lung Neoplasms Mechanistically, circZNF208 upregulated SNCA expression by acting as a sponge of miR5p and subsequently promoted the resistance of NSCLC cells to low linear energy transfer (LET) X-rays. +other 33892093 hsa-mir-7 Carcinoma, Non-Small-Cell Lung Mechanistically, circZNF208 upregulated SNCA expression by acting as a sponge of miR5p and subsequently promoted the resistance of NSCLC cells to low linear energy transfer (LET) X-rays. +exosome 33891698 hsa-mir-181 Acute Lung Injury Our results showed that the lncRNA-p21-induced downregulation of miR-181 might suppress epithelial cell apoptosis and alleviate lung tissue injury by upregulating SIRT1 expression, suggesting the potential therapeutic effects of lncRNA-p21 on SALI. In conclusion, we found that the novel lncRNA-p21/miR-181/SIRT1 pathway may play an important role in the progression of SALI, and MSC-derived exosomes may be a new therapeutic strategy for this disease. +lncRNA target 33891564 hsa-mir-580 Carcinoma, Hepatocellular 5p and inhibited CCL2 secretion into tumor microenvironment by decrease the expression of PPARalpha in HCC cells, then inhibited the pro-inflammatory cytokine release from macrophages by regulating the COX-2/PGE2 pathway. +genetics_overexpression_promote 33891267 hsa-mir-506 Osteosarcoma The promoting effects of FGD5-AS1 overexpression on OSA cell proliferation and migration could be counteracted by miR +other 33891266 hsa-mir-29a Liver Neoplasms CONCLUSION: COL4A1 is negatively regulated by XPD-miR-29a-3p axis and promotes liver cancer progression in vitro. +other 33891159 hsa-mir-19b Antiphospholipid Syndrome miR-19b-3p and miR-20a-5p are associated with the levels of antiphospholipid antibodies in patients with antiphospholipid syndrome. +other 33891159 hsa-mir-20a Antiphospholipid Syndrome Monocyte expression of miR-19b-3p and miR-20a-5p is low in APS, and patients with the lowest microRNA expression presented the highest levels of antiphospholipid antibodies. +genetics_GWAS 33890616 hsa-let-7 Death In Caenorhabditis elegans, let-7 is a component of the heterochronic (developmental timing) gene regulatory network, and loss-of-function mutations of let-7 result in lethality during the larval to adult transition due to misregulation of the conserved let-7 target, lin-41. +circulation_biomarker_diagnosis_ns 33890321 hsa-mir-28 Mesothelioma Thus, this study aimed to demonstrate the mesothelioma-inducing potential of chrysotile at the mesothelial cellular level and the function of microRNA-28 in malignantly transformed mesothelial MeT-5A cells. Surprisingly, the content of miR-28 in the blood of mesothelioma patients was higher than that in control subjects. +other 33890321 hsa-mir-28 Neoplasms, Mesothelial Thus, this study aimed to demonstrate the mesothelioma-inducing potential of chrysotile at the mesothelial cellular level and the function of microRNA-28 in malignantly transformed mesothelial MeT-5A cells. +other 33890137 hsa-mir-9 Leukemia, Megakaryoblastic, Acute 5p, titrating them away from TGF-betaR mRNAs. +other 33890137 hsa-mir-17 Leukemia, Megakaryoblastic, Acute 5p, titrating them away from TGF-betaR mRNAs. +other 33890137 hsa-mir-106 Leukemia, Megakaryoblastic, Acute 5p, titrating them away from TGF-betaR mRNAs. +lncRNA target 33889573 hsa-mir-153 Carcinoma, Hepatocellular SULF2-induced CAFs attenuated HCC apoptosis by activating the SDF-1/CXCR4/PI3K/AKT signaling pathway and induced EMT through the SDF-1/CXCR4/OIP5-AS1/miR +lncRNA target 33889541 hsa-mir-9 Glioblastoma Herein, based on a variety of bioinformatics tools for the reverse prediction of target genes associated with the prognosis of GBM, a ceRNA network of AGAP2-AS1-miR5p-MMP2/MMP9 was constructed, and a potential therapeutic target for GBM was identified. +other 33889522 hsa-mir-942 Adenocarcinoma of Lung circFBXW7 attenuates malignant progression in lung adenocarcinoma by sponging miR-942-5p. +other 33889521 hsa-mir-4633 Carcinoma, Non-Small-Cell Lung ISOC1 and its intronic miR-4633, both of them could promote NSCLC cell proliferation, migration, invasion, and cell cycle progression. +lncRNA target 33888994 hsa-mir-23a Squamous Cell Carcinoma of Head and Neck RESULTS: The up-regulation of ZEB1-AS1 and downregulation of miR-23a-3p (miR-23a) were found in OSCC cancer tissues. CONCLUSION: The newly identified lncRNA ZEB1-AS1 functions as a tumor promoter in OSCC through regulation of miR-23a. +lncRNA target 33888871 hsa-mir-335 Carcinoma, Renal Cell Here, we show that miR-335, an anti-onco-miRNA, is downregulation in tumor tissue and inhibited ccRCC cell proliferation, invasion, and migration. Together, our study establishes a new miR-335/KDM3A/YAP1 regulation axis, which provided new insight and potential targeting of the metastasized ccRCC. +lncRNA target 33888655 hsa-mir-132 Attention Deficit Disorder with Hyperactivity 3p levels of children with ADHD may be a therapeutic target of the disease. +lncRNA target 33888645 hsa-mir-204 Stomach Neoplasms 3p expression inhibited KRAS expression in HGC-27 cells, and ectopic expression of LINC00514 enhanced KRAS expression. +other 33888045 hsa-mir-21 Hypertension CONCLUSION: The study results revealed significantly higher miRNA 21 and aldosterone in RH patients than in healthy individuals and newly diagnosed hypertensives. +lncRNA target 33887883 hsa-mir-627 Cicatrix, Hypertrophic Conclusions: miR-627 expression in human hypertrophic scars is down-regulated; miR-627 can inhibit the proliferation and promote the apoptosis of Fbs in human hypertrophic scar by targeted inhibition of IGF- expression. +genetics_overexpression_suppress 33887878 hsa-mir-125b Lymphoma, Large B-Cell, Diffuse The EVcarried miR125b5p reduced the sensitivity of DLBCL cells to rituximab, which was averted by overexpression of TNFAIP3. +other 33887693 hsa-mir-122 Carcinoma, Renal Cell From monolayer network to three-layer network, hsa-mir-122 is identified as an important molecule in the oncogenesis and progression of ccRCC, offering new strategies to further study of the carcinogenic mechanism of ccRCC. +genetics_overexpression_promote 33887625 hsa-mir-760 Carcinoma, Hepatocellular RESULTS: We demonstrated that miR-760 overexpression suppressed cell proliferation, migration, and invasion in HCC. +genetics_overexpression_promote 33887588 hsa-mir-124 Colorectal Neoplasms 3p mimics or inhibitor reversed the effects induced by lncRNA-cCSC1 overexpression or silencing on cell proliferation of CRC. +other 33887587 hsa-mir-29c Stomach Neoplasms The circACC1/miR-29c-3p/FOXP1 network plays a key role in gastric cancer by regulating cell proliferation. +lncRNA target 33887546 hsa-mir-203a Nasopharyngeal Carcinoma Our findings reveal a new type of circRNA, circTRAF3, which acts as an oncogene in NPC and targets miR-203a-3p/AKT3 pathway. +genetics_GWAS 33887464 hsa-mir-17 Carcinoma, Non-Small-Cell Lung RESULTS: We identified miR-17 as an epigenetic regulator of LKB1 in NSCLC and confirmed targeting of miR-17 to LKB1 3' untranslated region by luciferase reporter assay. +transcription factor target 33887395 hsa-mir-21 Lung Injury In conclusion, MET/PLGANPS may alleviate RILI by inhibiting the miR-21/TGF-beta1/Smad3 pathway, which would provide a new target for the treatment of radiation-induced lung injury. +transcription factor target 33887325 hsa-mir-218 Porcine Reproductive and Respiratory Syndrome Taken together, these results demonstrate that PRRSV-induced miR-218 downregulation serves to inhibit the type I interferon response and may provide a novel therapeutic target for treatment of PRRSV and other viral infections. +transcription factor target 33887260 hsa-mir-17 Urinary Bladder Neoplasms Collectively, our results demonstrate that BBR exerts anti-tumor effects by perturbing JAK1-STAT3 signaling through the upregulation of miR +genetics_knock down_suppress 33887222 hsa-mir-205 Duane Retraction Syndrome In summary, Malat1 knockdown diminished hRMEC dysfunctions by regulating miR5p/VEGF-A, providing a useful insight for exploring new therapeutic target for DR. +genetics_overexpression_promote 33886809 hsa-mir-629 Osteosarcoma 5p was overexpressed in osteosarcoma tissues and cells, and thereby enhanced cell proliferation and migration. +genetics_knock down_suppress 33886117 hsa-mir-7 Parkinson Disease CONCLUSIONS: LINC00943 knockdown could attenuate MPP(+)-triggered neuron injury by regulating the miR5p/CXCL12 axis, hinting at a promising therapeutic target for PD treatment. +genetics_overexpression_suppress 33886061 hsa-mir-145 Cardiomegaly In this study, H9C2 cells were overexpressed with microRNA +genetics_overexpression_promote 33886022 hsa-mir-25 Carcinoma, Hepatocellular RESULTS: miR-25 was overexpressed in HCC tissue compared with adjacent normal tissue and significantly correlated with a poorer prognosis. +other 33885954 hsa-mir-93 Acute Kidney Injury NEAT1 might aggravate LPS-induced injury in HK2 cells by regulating miR5p/TXNIP axis, providing a potential therapeutic strategy for sepsis-associated AKI. +other 33885954 hsa-mir-93 Sepsis NEAT1 might aggravate LPS-induced injury in HK2 cells by regulating miR5p/TXNIP axis, providing a potential therapeutic strategy for sepsis-associated AKI. +genetics_knock down_promote 33885332 hsa-mir-498 Esophageal Neoplasms Overexpression of miR-498 or knockdown of DNMT3b enhanced the radiosensitivity of EC cells. +other 33885186 hsa-mir-145 Endometrial Neoplasms 3p/TCF4 axis. +lncRNA target 33885171 hsa-mir-185 Prostatic Neoplasms CONCLUSIONS: These findings suggest that DANCR exerts oncogenic roles in prostate cancer via the miR +exosome 33884828 hsa-mir-338 Carcinoma, Hepatocellular In conclusion, BMSC-derived exosomal miR +transcription factor target 33884382 hsa-mir-182 Breast Neoplasms Thus, our integrated functional analysis suggests that miR-182 might lead to a new therapeutic target in BC manifestation. +lncRNA target 33884030 hsa-mir-588 Osteosarcoma Taken together, these findings indicated that miR-588 may serve as an independent prognostic factor and tumor suppressor in OS. +other 33884013 hsa-mir-103a Zoonoses CONCLUSION: To our knowledge, this is the first study to evaluate miR-21 and miR-103a in toxocariasis, which shed light on the fundamental role of it as a biomarker and diagnostic tool. +circulation_biomarker_diagnosis_up 33883934 hsa-mir-194 Wilms Tumor 5p), and YAP (yes-associated protein in Hippo pathway) in tumor and matched adjacent normal tissues and blood collected from 49 WT patients. +genetics_overexpression_promote 33883902 hsa-mir-516b Esophageal Squamous Cell Carcinoma MiR-516b-5p overexpression inhibited the proliferation and motility of ESCC cells. +other 33883889 hsa-mir-17 Reperfusion Injury CONCLUSION: PPF protects the MIRI by modulating the HOTAIR/miR5p/STAT3 axis. +other 33883598 hsa-mir-10b Celiac Disease EV membrane protein and non-coding RNA composition are highly specific to the parent cell type; for example, miR-10b is enriched in MSC-EVs relative to CDC-EVs, while Y RNA fragments follow the opposite pattern. +other 33883592 hsa-mir-29 Diabetes Mellitus In conclusion, our findings suggest that QCSPION could regulate the expression of the miR-29 family, which in turn increases the expression of glucose transporters and IGF-1, thereby reducing diabetic complications. +circRNA target 33883408 hsa-mir-24 Stomach Neoplasms 5p with circ_0049447 proven by luciferase reporter assay indicated that circ_0049447 may inhibit GC by sponging certain miRNA. +circulation_biomarker_diagnosis_down 33883305 hsa-mir-1228 Stomach Neoplasms miR-1228 was highly expressed in serum exosomes of patients with gastric cancer with a area under ROC curve (AUC) of 0.865. +circRNA target 33882945 hsa-mir-338 Colonic Neoplasms CONCLUSION: Circ_0055625 repression inhibited the progression and radioresistance of colon cancer by downregulating MSI1 through sponging miR3p. +lncRNA target 33882812 hsa-mir-486 Breast Neoplasms 5p, inhibited H19 lncRNA and ICAM-1 expression and selectively regressed mBC cell aggressiveness. +transcription factor target 33882492 hsa-mir-210 Myocardial Infarction In short, our results suggest that miR-210 exerts anti-apoptotic and anti-autophagic effects in hypoxic cardiomyocytes, which alleviates myocardial injury in response to hypoxia. +transcription factor target 33882484 hsa-mir-506 Angelman Syndrome CONCLUSION: MiR3p can promote the proliferation and migration of VSMCs via targeting KLF4, which can probably contribute to the pathogenesis of AS. +genetics_knock down_promote 33882457 hsa-mir-338 Stomach Neoplasms EED knockdown could restrain the proliferative and invasive abilities of GC cells by inducing miR +target gene 33882369 hsa-mir-451a Pancreatic Neoplasms LncRNA CRNDE promotes the progression and angiogenesis of pancreatic cancer via miR-451a/CDKN2D axis. +target gene 33882368 hsa-mir-10b Breast Neoplasms FOXO3a inhibits the EMT and metastasis of breast cancer by regulating TWIST-1 mediated miR-10b/CADM2 axis. +lncRNA target 33882171 hsa-mir-195 Osteosarcoma In this research, osteosarcoma biomarker (miRNA-195) was identified by citrate-capped GNP-colorimetric assay. This simple assay helps to quantify the level of miRNA-195 target DNA and to diagnose the osteosarcoma. +genetics_overexpression_promote 33882126 hsa-mir-15a Urinary Bladder Neoplasms These promoting effects were also hindered when miR-15a-5p was overexpressed or HMGA2 was silenced in BC cells. In conclusion, exosomal LINC00355 derived from CAFs promotes BC cell proliferation and invasion by regulating miR-15a-5p/HMGA2 axis. +genetics_overexpression_suppress 33882027 hsa-mir-370 Squamous Cell Carcinoma of Head and Neck Based on rescue assays, FoxM1 overexpression or miR-370 downregulation partially recovered the inhibitory effect of MNX1-AS1 silencing on LSCC cells. +other 33881945 hsa-mir-16 Pneumonia, Mycoplasma MiR-16 interacted with LINC01128, and miR-16 was high-expressed in PE placentae. +lncRNA target 33881703 hsa-mir-365 Diabetic Nephropathies In addition, it was demonstrated that miR-365 could target BDNF. +exosome 33881681 hsa-mir-671 Myocardial Infarction This study suggested that adMSC-derived exosomal miR-671 directly targets TGFBR2 and reduces Smad2 phosphorylation to alleviate MI-like symptoms both in vivo and in vitro. +genetics_knock down_suppress 33880997 hsa-mir-449a Carcinoma, Hepatocellular circ_LRIG3 knockdown inhibited the progression of HCC cells by sponging miR-449a. +other 33880613 hsa-mir-126 Pituitary Diseases Low levels of S-miR3p due to endothelial dysfunction may lead to high IP-VEGF-A, which is closely related to complications after CABG. +other 33880613 hsa-mir-126 Peripheral Arterial Disease Conversely, S-miR3p on day 7 after surgery was lower in patients with PAD than in patients without PAD. +genetics_knock down_suppress 33880596 hsa-mir-149 Squamous Cell Carcinoma of Head and Neck Furthermore, DLEU1 knockdowninduced inhibition of OSCC cell proliferation was significantly reversed by the miR1495p antagomir. Knockdown of lncRNA DLEU1 reversed the proliferation of OSCC cells via regulation of the miR1495p/CDK6 axis. +genetics_knock down_promote 33880595 hsa-mir-24 Carcinoma, Non-Small-Cell Lung Of note, overexpression of miR243p markedly abolished the exogenous hsa_circ_0058357induced excessive proliferation, migration and apoptosis resistance of NSCLC cells. +lncRNA target 33880593 hsa-mir-195 Breast Neoplasms In breast cancer lncRNA FGD5AS1 serve a key role in glycolysis and tumor progression via the miR1955p/NUAK2 axis. +lncRNA target 33880592 hsa-mir-125b Lupus Erythematosus, Systemic It was also determined that hsa_circ_0010957 mediated microRNA (miR)125b/STAT3 signaling and subsequent secretion of inflammatory cytokines interleukin (IL)18, IL6 and IL17, which are important factors in the process of SLE. In conclusion, increased hsa_circ_0010957 may be involved in SLE pathogenesis via miR125b/STAT3 signaling. +genetics_knock down_promote 33880589 hsa-mir-1294 Carcinoma, Hepatocellular circ-PRKCI overexpression promoted the viability, invasion and migration of HCCLM3 cells, which was also reversed by the overexpression of miR-1294 and miR +genetics_knock down_promote 33880589 hsa-mir-186 Carcinoma, Hepatocellular circ-PRKCI overexpression promoted the viability, invasion and migration of HCCLM3 cells, which was also reversed by the overexpression of miR-1294 and miR +lncRNA target 33880581 hsa-mir-5580 Mouth Neoplasms In addition to the observation that miR55803p promoted the malignant phenotypes of OC, it was also revealed that miR55803p inhibited OC cell viability, proliferation and migration by suppressing LAMC2. +transcription factor target 33880382 hsa-mir-34a Diabetic Nephropathies PURPOSE: To explore the regulatory effects of liraglutide on the kidney and liver through the miR-34a/SIRT1 pathway with related factors in diabetic nephropathy (DN) rats. CONCLUSION: Liraglutide, through its effect on the miR-34a/SIRT1 pathway, may have a protective role in the kidney and liver of DN rats. +circulation_biomarker_diagnosis_up 33880375 hsa-mir-720 Diabetes Mellitus, Type 2 In this study, circulating miR-720 was significantly higher in the T2D group than the control group, and miR-270 was positive correlated with FBG, while negatively correlated with FINS. +circulation_biomarker_diagnosis_up 33880375 hsa-mir-270 Diabetes Mellitus, Type 2 In this study, circulating miR-720 was significantly higher in the T2D group than the control group, and miR-270 was positive correlated with FBG, while negatively correlated with FINS. +lncRNA target 33880049 hsa-mir-200c Opitz GBBB Syndrome, X-Linked In this work, we aimed to explore the effects of the MALAT1/miR-200c/NRF2 regulatory axis on the pyroptosis and oxidative stress (Oxidative stress, OS) of renal podocytes in high glucose (HG) environment and whether the lipid-lowering drug atorvastatin (AT) can relieve renal OS through this approach. Further, atorvastatin protected MPC-5 cells from cell pyroptosis and downregulated the level of renal OS via attenuating the expression of MALAT1 and miR-200c. +other 33880049 hsa-mir-200c Diabetes Mellitus were detected by Western blotting and immunofluorescence, and the mRNA level of caspase-1, GSDMD, NLRP3, NRF2, MALAT1, miR-200c was tested by qRT-PCR. Further, the expression of GSDMD, MALAT1 and miR-200c were increased, while the level of NRF2, HO-1, OS-related indicators, were decreased simultaneously. +other 33879860 hsa-mir-210 Myocardial Ischemia Finally, we observed the functional restoration of the ischemia/reperfusion-injured heart by maintaining the intercommunication of EVs and cardiovascular cells derived from ASC(miR-210). +other 33879806 hsa-mir-619 Esophageal Squamous Cell Carcinoma 5p showed excellent values of area under the curve (AUC) >/= 0.80 for diagnosing stage I ESCC. +other 33879806 hsa-mir-1273f Esophageal Squamous Cell Carcinoma 5p showed excellent values of area under the curve (AUC) >/= 0.80 for diagnosing stage I ESCC. +lncRNA target 33879633 hsa-mir-203 Ovarian Neoplasms Moreover, ITPKA was negatively regulated by miR-203, a microRNA that has been previously reported to be upregulated in ovarian cancer. Taken together, the results of this study demonstrated the tumor suppressive roles of ITPKA in ovarian cancer and provided a good explanation for the oncogenic roles of miR-203. +lncRNA target 33879631 hsa-mir-607 Carcinoma, Non-Small-Cell Lung Through the above work, we found that hsa_circ_0072309 interacted with miR-607 via its miRNA response element to upregulate the expression of FTO, an m6A demethylase and downstream target of miR-607, thus promoting tumorigenesis of NSCLC. +other 33879548 hsa-mir-219 Prostatic Neoplasms 5p can be used as a biomarker to predict death risk in prostate cancer patients. +target gene 33879126 hsa-mir-539 Osteosarcoma MiRNA-539 may inhibit the cell proliferation, migration and invasion of osteosarcoma cells and promote the apoptosis of osteosarcoma cells by targeting on TRIAP1. +transcription factor target 33878909 hsa-mir-204 Cognition Disorders MiR5p could serve as a potential therapeutic target for the lightening of cognitive dysfunction induced by isoflurane. +lncRNA target 33878446 hsa-mir-34a Carcinoma, Hepatocellular In conclusion, TET1 is a tumor suppressor in the progression of HCC by regulating the miR-34a/BACH1/p53 axis, and may contribute to the improvement of HCC prognosis and therapy. +circulation_biomarker_diagnosis_ns 33877895 hsa-mir-21 Heart Failure Conclusion: Circulating miR-21 levels were decreased in HFrEF patients and hematocrit was identified as a factor associated with this abnormality. +lncRNA target 33877664 hsa-mir-155 Brain Ischemia Regulation of miRNA-155 expression can target neuronal pacing ion channel HCN channel to regulate the release of amino acid transmitters, thereby alleviating the progress of cerebral ischemia. +other 33877554 hsa-mir-766 Glioma 3p were significantly down-regulated in GBM. +other 33877554 hsa-mir-10b Glioma 3p were significantly down-regulated in GBM. +other 33877554 hsa-mir-542 Glioma 3p were significantly down-regulated in GBM. +other 33877554 hsa-mir-92b Glioma 3p were significantly down-regulated in GBM. +other 33877554 hsa-mir-1 Glioma 3p were significantly down-regulated in GBM. +other 33877554 hsa-mir-455 Glioma 3p were significantly down-regulated in GBM. +other 33877554 hsa-mir-184 Glioma 3p were significantly down-regulated in GBM. +other 33877554 hsa-mir-206 Glioma 3p were significantly down-regulated in GBM. +lncRNA target 33877318 hsa-mir-1287 Grave Disease 5p axis modulated TGF-beta1-induced increases in cell adhesion factor levels and TED orbital fibroblast activation through EGFR/AKT signaling. +genetics_overexpression_promote 33876722 hsa-mir-411 Pneumonia, Mycoplasma 5p mimic promoted cell proliferation, migration, and invasion, and the plasmid-mediated PTEN overexpression reversed the effect of the miR +circulation_biomarker_diagnosis_ns 33876465 hsa-mir-21 Anaphylaxis CONCLUSIONS: These findings provide, for the first time, some insights into the anaphylactic miRNA serum profile in children and point to miR +genetics_knock down_promote 33875796 hsa-mir-4646 Stomach Neoplasms 5p, one of Drosha-independent mirtronic miRNA, is aberrant up-regulated in Drosha-low expressed GC and Drosha-knockdown gastric cancer cells. +lncRNA target 33875790 hsa-mir-135a Hypoxia-Ischemia, Brain M2 microglia-derived EVs delivered miR-135a-5p into neuronal cells to inhibit TXNIP expression, which further inhibited the activation of NLRP3 inflammasome, thereby reducing neuronal autophagy and ischemic brain injury. +genetics_knock down_promote 33875646 hsa-mir-548c Triple Negative Breast Neoplasms 5p/miR-548c-3p efficiently promoted the cell proliferation, migration, and invasion suppressed by circBACH2 knockdown in the TNBC cell lines. +genetics_knock down_promote 33875646 hsa-mir-186 Triple Negative Breast Neoplasms 5p/miR-548c-3p efficiently promoted the cell proliferation, migration, and invasion suppressed by circBACH2 knockdown in the TNBC cell lines. +transcription factor target 33875643 hsa-mir-124 Nasopharyngeal Carcinoma Our previous study demonstrated that miR-124 could target Foxq1 to inhibit NPC metastasis. In conclusion, our results show that Foxq1 is regulated by miR-124 and that it promotes NPC metastasis by inducing VM via the EGFR signaling pathway. +lncRNA target 33875617 hsa-mir-27a Reperfusion Injury, Cerebral Ischemia Thus, MiR-27a-3p appears to suppress CI/R injury by targeting FOXO1. +genetics_overexpression_promote 33875577 hsa-mir-181a-2 Sepsis 3p, and overexpression of GJB2 reversed the anti-inflammatory and antiapoptotic effects of miR-181a +genetics_overexpression_promote 33875577 hsa-mir-181a Sepsis 3p, and overexpression of GJB2 reversed the anti-inflammatory and antiapoptotic effects of miR-181a +lncRNA target 33875234 hsa-mir-29c Ovarian Neoplasms CONCLUSION: Our results demonstrate that miR-29c downregulates B7-H3 to inhibit NK-cell exhaustion and associated with glycolysis, which suggest that NK cells may be a new target of anti-B7-H3 therapy in ovarian cancer patients. +other 33874912 hsa-mir-124 Glomerulonephritis, IGA A multilayer regulatory network was constructed and several hub-DEGs (Tp53, STAT3, Jun, etc.), DEmiRs (miR-124, let-7b, etc.), TFs (NF-kB, etc.), and lncRNAs (HOTAIR, etc.) were introduced as potential factors in the pathogenesis of IgAN. +lncRNA target 33874704 hsa-mir-627 Cicatrix, Hypertrophic Conclusion: miR-627 can inhibit the proliferation of Fbs in hypertrophic scar by targeting IGF-. +circulation_biomarker_diagnosis_ns 33872218 hsa-mir-503 Atherosclerosis 5p) was enriched in either extracellular vesicles (EVs), secreted by oxidized low-density lipoprotein-treated macrophages, or the EVs from peripheral blood mononuclear cells of atherosclerosis patients. +genetics_overexpression_promote 33871770 hsa-mir-216b Glioblastoma Cell proliferation assay showed that MYCNOS and FOXM1 overexpression resulted in an increased proliferation rate of GBM cells, while miR-216b overexpression suppressed cell proliferation. +other 33871591 hsa-mir-186 Cognition Disorders The abundance of ProteobacteriaandGammaproteobacteria was higher in MCI participants and was correlated with hsa-let-7g-5p, hsa-miR-107, and hsa-miR3p. +other 33871591 hsa-mir-107 Cognition Disorders The abundance of ProteobacteriaandGammaproteobacteria was higher in MCI participants and was correlated with hsa-let-7g-5p, hsa-miR-107, and hsa-miR3p. +other 33871591 hsa-let-7g Cognition Disorders The abundance of ProteobacteriaandGammaproteobacteria was higher in MCI participants and was correlated with hsa-let-7g-5p, hsa-miR-107, and hsa-miR3p. +genetics_knock down_suppress 33871149 hsa-mir-26b Pancreatic Carcinoma METHODS: Overexpression or knockdown of CDK14 or miR-26b was generated in pancreatic cancer cell lines and the function of CDK14 and miR-26b on cell phenotype and the Wnt signaling pathway was determined using 3-(4,5-dimethylthiazol +other 33870836 hsa-mir-145 Diabetes Mellitus, Type 2 Conclusions: Functional miR-143/145 variants might influence the risk of T2DM. +genetics_overexpression_promote 33870669 hsa-mir-610 Neuroblastoma Besides, overexpression of miR-610 hindered NB cell viability and facilitated cell apoptosis, whereas silencing miR-610 led to reverse results. +lncRNA target 33869908 hsa-mir-155 Plaque, Atherosclerotic 5p in foam cell atherosclerosis inhibition. +genetics_knock down_promote 33869780 hsa-mir-205 Acute Kidney Injury TapSAKI knockdown or miR-205 overexpression alleviated LPS-induced cytotoxicity in HK-2 cells. +lncRNA target 33869780 hsa-mir-205 Sepsis Our current study suggested that TapSAKI silencing relieved LPS-induced injury in HK-2 cells at least in part by sponging miR-205 and regulating the IRF3 signaling pathway, highlighting a novel understanding for sepsis pathogenesis and a promising target for this disease treatment. +lncRNA target 33869779 hsa-mir-645 Colorectal Neoplasms Furthermore, circ_0026344 sponged miR-645 to inhibited Akt/mTOR signal pathway in propofol-treated CRC cells. +genetics_knock down_promote 33869744 hsa-mir-195 Squamous Cell Carcinoma of Head and Neck The effects of LINC00461, miR-195, and HOXA10 on the EMT and chemoresistance of HNSCC cells were analyzed by comprehensive analysis of gain- and loss-of-function techniques. +genetics_knock down_promote 33869743 hsa-mir-224 Triple Negative Breast Neoplasms 5p reversed the effects of MIR503HG overexpression on TNBC cells, while overexpression of HOXA9 reversed the effect of MIR503HG knockdown. +lncRNA target 33869741 hsa-mir-124 Glioma MicroRNA-124 de-targeted SFV-AM6-124T selectively replicates in glioma cells, and it can infect orthotopic GL261 gliomas when administered intraperitoneally. +other 33869675 hsa-mir-96 Spinal Cord Injuries In particular, miR-96 provides a promising therapeutic opportunity to improve the outcomes of clinical interventions, including the way SCI injuries are evaluated and treated. +circulation_biomarker_diagnosis_ns 33869627 hsa-mir-21 Prostatic Neoplasms In mechanism, circSLC8A1 exhibited a direct interaction with miR-21 and displayed as a miRNA sponge to inhibit PCa progression. CONCLUSIONS: CircSLC8A1 functioned as an inhibitor of neoplasm via modulating the miR-21 and might serve as a prospective target for the treatment of PCa. +genetics_overexpression_promote 33869277 hsa-mir-7b Spinal Cord Injuries On the contrary, the overexpression of miR-7b-3p upon in vitro oxidative stress condition (mimicking the SCI environment) significantly reduced the expression level of Wipf2, as observed in vivo, confirming it as a direct miR-7b-3p target. +lncRNA target 33869216 hsa-mir-574 Esophageal Squamous Cell Carcinoma 5p/SMAD4 axis in the progression of ESCC and provide emerging therapeutic targets for ESCC patients. +transcription factor target 33869205 hsa-mir-22 Heart Diseases We aimed to reveal the role of miR-22 in septic cardiomyopathy and to explore the underlying mechanisms. Our results revealed that targeting miR-22 may become a new strategy for septic cardiomyopathy treatment. +transcription factor target 33869205 hsa-mir-22 Cardiomyopathies We aimed to reveal the role of miR-22 in septic cardiomyopathy and to explore the underlying mechanisms. Our results revealed that targeting miR-22 may become a new strategy for septic cardiomyopathy treatment. +exosome 33869178 hsa-mir-3682 Carcinoma, Hepatocellular CONCLUSION: Our study elucidates that exosomal miR3p attenuates angiogenesis by targeting ANGPT1 through RAS-MEK1/2-ERK1/2 signaling and provides novel potential targets for liver cancer therapy. +genetics_overexpression_promote 33869051 hsa-mir-877 Carcinoma, Non-Small-Cell Lung Followed functional experiments indicated that overexpression of LINC00941 accelerated angiogenesis and NSCLC tumor progression via miR +genetics_overexpression_promote 33868799 hsa-mir-155 Alcoholism 5p level and its overexpression decreased p-IRS1 (ser 307) and increased p-IR (Tyr 1185) levels, and meanwhile inhibited the mTOR signaling pathway. +transcription factor target 33868799 hsa-mir-155 Cardiomyopathy, Alcoholic We propose that miR-155 may serve as a novel potential therapeutic target for alcoholic heart disease. +lncRNA target 33868788 hsa-mir-372 Liver Neoplasms In conclusion, the results indicated that FER1L4 could inhibit the expression of miR-106a-5p/miR5p, to activate E2F1-mediated NF-kappaB pathway, leading to drug resistance in liver cancer. +lncRNA target 33868788 hsa-mir-106 Liver Neoplasms In conclusion, the results indicated that FER1L4 could inhibit the expression of miR-106a-5p/miR5p, to activate E2F1-mediated NF-kappaB pathway, leading to drug resistance in liver cancer. +lncRNA target 33868788 hsa-mir-106a Liver Neoplasms In conclusion, the results indicated that FER1L4 could inhibit the expression of miR-106a-5p/miR5p, to activate E2F1-mediated NF-kappaB pathway, leading to drug resistance in liver cancer. +target gene 33868787 hsa-mir-140 Osteosarcoma miR-140 inhibits osteosarcoma progression by impairing USP22-mediated LSD1 stabilization and promoting p21 expression. +target gene 33868783 hsa-mir-4660 Osteosarcoma MAFG-driven osteosarcoma cell progression is inhibited by a novel miRNA miR-4660. +other 33868612 hsa-mir-21 Stomach Neoplasms novel biomarkers (miRNA-21 and miRNA-29) could be proposed as potential treatments of gastric cancer +other 33868612 hsa-mir-29 Stomach Neoplasms novel biomarkers (miRNA-21 and miRNA-29) could be proposed as potential treatments of gastric cancer +lncRNA target 33868482 hsa-mir-126 Sarcoma, Synovial HOTAIR was highly expressed in SS tissues, wherein it could promote the proliferation, invasion and migration of SS cells by increasing the expression of SDF-1 via miR-126 inhibition. +genetics_GWAS 33868472 hsa-mir-199a Carcinoma, Non-Small-Cell Lung Epigenetic silencing of microRNA-199a-5p promotes the proliferation of non-small cell lung cancer cells by increasing AKAP1 expression. +other 33868470 hsa-mir-124 Breast Neoplasms Activation of GPER by E2 promotes proliferation, invasion and migration of breast cancer cells by regulating the miR-124/CD151 pathway. +target gene 33868467 hsa-mir-497 Carcinoma, Non-Small-Cell Lung lncRNA LINC00473 promotes proliferation, migration, invasion and inhibition of apoptosis of non-small cell lung cancer cells by acting as a sponge of miR-497-5p. +transcription factor target 33868233 hsa-mir-210 Inflammation Induced miR-210 and miR-3570 inhibit inflammatory cytokine production by targeting RIPK2, thereby avoiding excessive inflammation. +transcription factor target 33868233 hsa-mir-570 Inflammation Induced miR-210 and miR-3570 inhibit inflammatory cytokine production by targeting RIPK2, thereby avoiding excessive inflammation. +genetics_overexpression_promote 33867846 hsa-mir-92b Inflammation Looking into the molecular mechanisms of regulation of inflammatory injury by miR-92b, we observed that overexpression of miR-92b restrained TLR4/NF-kappaB by activating the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT)/beta-catenin pathway. Collectively, these findings show that enforced expression of miR-92b alleviates LPS-induced inflammatory injury by activating the PI3K/AKT/beta-catenin pathway via targeting PTEN, suggesting a potential application for miR-92b-based therapy to treat endometritis or other inflammatory diseases. +lncRNA target 33867845 hsa-mir-4485 Fractures, Bone MicroRNA-4485 (miR-4485), which we found to be upregulated in COVID-19 patients, negatively regulates osteogenic differentiation. Taken together, our findings highlight that up-regulation of miR-4485 is responsible for the suppression of osteogenic differentiation in COVID-19 patients, and TLR-4 is the potential target through which miR-4485 acts, providing a promising target for pro-fracture-healing and anti-osteoporosis therapy in COVID-19 patients. +lncRNA target 33867838 hsa-mir-1 Breast Neoplasms Taken together, our results elucidate that circMETTL3 promotes breast cancer progression through circMETTL3/miR5p/CDK1 axis. +exosome 33867829 hsa-mir-4709 Glioblastoma In summary, this study reveals for the first time that low-dose radiation-induced exosomal circ-METRN plays an oncogenic role in glioblastoma progression and radioresistance through miR +transcription factor target 33867828 hsa-mir-128 Kidney Diseases Taken together, TF exhibits a strong nephroprotective ability to suppress CaOx-induced kidney damage through the recovery of the antioxidant defense system regulated by miR3p/SIRT1 axis. +lncRNA target 33867824 hsa-mir-18a Breast Neoplasms In conclusion: our study proved that HHT suppressed breast cancer cell growth and promoted apoptosis mediated by regulating of the miR-18a-3p-AKT-mTOR signaling pathway, HHT may be a promising antitumor agent in breast cancer treatment. +circulation_biomarker_diagnosis_ns 33867822 hsa-mir-1 Myocardial Infarction Conclusion: The circulating exosomal miR3p after MI inhibited the CM-induced apoptosis and autophagy of renal tubular epithelial cells, and improved the renal function of rats by targeting ATG13 and activating the AKT signaling pathway. +transcription factor target 33867821 hsa-mir-146a Stomach Neoplasms Conclusions: miR-146a-5p targets PRSS1 and suppresses the growth and proliferation of MGC803 cells. +genetics_overexpression_promote 33867818 hsa-mir-552 Pancreatic Carcinoma Functionally, overexpression of miR-552 promoted pancreatic cancer cell migration and inhibition of miR-552 attenuated this phenotype. +genetics_GWAS 33867710 hsa-mir-570 Urinary Bladder Neoplasms miRNA 570 C/G (rs4143815), miRNA 30c A/G (rs928508) and miRNA 181a C/T (rs12537) single nucleotide polymorphisms (SNPs) were genotyped by allelic discrimination TaqMan assay in 100 bladder cancer (BC) patients and 100 healthy controls. +genetics_GWAS 33867710 hsa-mir-181a Urinary Bladder Neoplasms miRNA 570 C/G (rs4143815), miRNA 30c A/G (rs928508) and miRNA 181a C/T (rs12537) single nucleotide polymorphisms (SNPs) were genotyped by allelic discrimination TaqMan assay in 100 bladder cancer (BC) patients and 100 healthy controls. +circulation_biomarker_diagnosis_down 33866949 hsa-mir-125a Multiple Sclerosis, Relapsing-Remitting 5p in the peripheral blood mononuclear cells (PBMCs) of subjects with relapsing-remitting multiple sclerosis (RRMS). +circulation_biomarker_diagnosis_down 33866949 hsa-mir-218 Multiple Sclerosis, Relapsing-Remitting 5p in the peripheral blood mononuclear cells (PBMCs) of subjects with relapsing-remitting multiple sclerosis (RRMS). +lncRNA target 33866896 hsa-mir-125a Lupus Erythematosus, Systemic CONCLUSION: Our findings postulate that miR-125a could act as a candidate therapeutic target for its possible regulation of inflammation in jSLE patients. +other 33866227 hsa-mir-138 Subarachnoid Hemorrhage RESULTS: After SAH, miR-132, miR-134, and miR-138 expressions in the frontal lobes of rats increased in impoverished environment on the 7th day and in the enriched environment on the 14th day. +other 33866227 hsa-mir-134 Subarachnoid Hemorrhage RESULTS: After SAH, miR-132, miR-134, and miR-138 expressions in the frontal lobes of rats increased in impoverished environment on the 7th day and in the enriched environment on the 14th day. +other 33866227 hsa-mir-132 Subarachnoid Hemorrhage RESULTS: After SAH, miR-132, miR-134, and miR-138 expressions in the frontal lobes of rats increased in impoverished environment on the 7th day and in the enriched environment on the 14th day. +other 33866193 hsa-let-7f Coronary Artery Disease 5p discriminate SCAD from AT-AMI patients and also shed light on the pathological mechanisms underlying this condition. +other 33866193 hsa-mir-223 Coronary Artery Disease 5p discriminate SCAD from AT-AMI patients and also shed light on the pathological mechanisms underlying this condition. +other 33866193 hsa-mir-151a Coronary Artery Disease 5p discriminate SCAD from AT-AMI patients and also shed light on the pathological mechanisms underlying this condition. +other 33866193 hsa-mir-146a Coronary Artery Disease 5p discriminate SCAD from AT-AMI patients and also shed light on the pathological mechanisms underlying this condition. +circulation_biomarker_prognosis_ns 33866108 hsa-mir-375 Esophageal Neoplasms High circulating miR-375 was associated with a longer OS (p = 0.02) in patients with esophageal adenocarcinoma (EAC). Elevated circulating miR-375 might be a prognostic marker for patients with EAC. +circulation_biomarker_diagnosis_ns 33866108 hsa-mir-200c Esophageal Neoplasms Increased circulating miR-200c-3p in GC showed a trend (p = 0.06) towards a shorter OS. +genetics_knock down_promote 33865997 hsa-mir-135a Hypertension The SHR-EVs from the miR135a-5p knockdown-treated fibroblasts lost their roles in inhibiting FNDC5 expression and promoting proliferation in VSMCs of both WKY and SHR. +transcription factor target 33865939 hsa-mir-137 Glaucoma The aim of this study is to investigate the role of miR-137 in glaucoma and illustrate the potential molecular mechanisms. Hence, miR-137 might be used as a novel therapeutic target to treat glaucoma. +genetics_knock down_promote 33865422 hsa-mir-122 Pancreatic Carcinoma PART1 was found to serve as a molecular sponge of miR-122, and miR-122 inhibition partially reversed the inhibitory phenotypes of PART1 knockdown on pancreatic cancer cells. +genetics_knock down_promote 33865414 hsa-mir-23c Carcinoma, Hepatocellular The results of MTT and Transwell assay showed that miR-23c inhibition restored the inhibitory effect of ZEB1-AS1 knockdown on HCC cells proliferation and invasion. +circulation_biomarker_prognosis_ns 33865271 hsa-mir-337 Osteosarcoma Furthermore, receiver operating characteristic (ROC) analysis verified that serum miR +circulation_biomarker_prognosis_ns 33865271 hsa-mir-3677 Osteosarcoma Furthermore, receiver operating characteristic (ROC) analysis verified that serum miR +circulation_biomarker_prognosis_ns 33865271 hsa-mir-582 Osteosarcoma Furthermore, receiver operating characteristic (ROC) analysis verified that serum miR +circulation_biomarker_prognosis_ns 33865271 hsa-mir-484 Osteosarcoma Furthermore, receiver operating characteristic (ROC) analysis verified that serum miR +circulation_biomarker_diagnosis_ns 33865244 hsa-mir-377 Diabetic Neuropathies METHODS: Based on the results of bioinformatics screening, miR-377 and miR-216a, their respective target molecules growth association protein 43 (GAP-43) and angiopoietin-like 4 protein (ANGPTL4), and related pathways peroxisome proliferator activated receptor gamma (PPARG) and chemerin were tested by RT-qPCR and ELISA in blood samples of DPN to analyze the correlation between these differentially expressed molecules and clinico-pathological factors of DPN. +circulation_biomarker_diagnosis_ns 33865244 hsa-mir-377 Diabetes Mellitus, Type 2 METHODS: Based on the results of bioinformatics screening, miR-377 and miR-216a, their respective target molecules growth association protein 43 (GAP-43) and angiopoietin-like 4 protein (ANGPTL4), and related pathways peroxisome proliferator activated receptor gamma (PPARG) and chemerin were tested by RT-qPCR and ELISA in blood samples of DPN to analyze the correlation between these differentially expressed molecules and clinico-pathological factors of DPN. +circulation_biomarker_diagnosis_ns 33865244 hsa-mir-216a Diabetes Mellitus, Type 2 METHODS: Based on the results of bioinformatics screening, miR-377 and miR-216a, their respective target molecules growth association protein 43 (GAP-43) and angiopoietin-like 4 protein (ANGPTL4), and related pathways peroxisome proliferator activated receptor gamma (PPARG) and chemerin were tested by RT-qPCR and ELISA in blood samples of DPN to analyze the correlation between these differentially expressed molecules and clinico-pathological factors of DPN. +circulation_biomarker_diagnosis_ns 33865244 hsa-mir-216a Diabetic Neuropathies METHODS: Based on the results of bioinformatics screening, miR-377 and miR-216a, their respective target molecules growth association protein 43 (GAP-43) and angiopoietin-like 4 protein (ANGPTL4), and related pathways peroxisome proliferator activated receptor gamma (PPARG) and chemerin were tested by RT-qPCR and ELISA in blood samples of DPN to analyze the correlation between these differentially expressed molecules and clinico-pathological factors of DPN. +genetics_overexpression_promote 33865032 hsa-mir-33a Multiple Myeloma Both high expression of miR-33a-5p and low expression of PIM1 reversed the suppressive effects of LINC01003 overexpression on cell adhesion and viability, and the promoting effect on apoptosis in MM cells. +circulation_biomarker_diagnosis_up 33865015 hsa-mir-200 Pre-Eclampsia miR-200 family has been shown to be associated with preeclampsia and upregulated in the plasma and placenta of preeclamptic patients. +lncRNA target 33864618 hsa-mir-662 Pancreatic Carcinoma CONCLUSIONS: Taken together, circ_03955 functions as a tumor promoter through miR-3662/HIF-1alpha axis, which might provide a novel sight for PC treatment. +other 33864612 hsa-mir-217 Asthma RESULTS: TGF-beta1, GAS5, HDAC4 were up-regulated, while miR-217 was down-regulated in bronchial mucosal tissues of asthmatic children and TGF-beta1-treated BEAS-2B cells. CONCLUSIONS: The lncRNA GAS5/miR-217/HDAC4 axis played an important role in regulating TGF-beta1-induced bronchial epithelial cells injury, thus contributing to asthma. +lncRNA target 33864447 hsa-mir-1a Bone Diseases CONCLUSION: Statin causes skeletal injury through induction of miR-1a excessive expression to decrease MAP3K1 gene expression. +transcription factor target 33864383 hsa-mir-147 Arthritis Anti-miR-147 therapy could alleviate the severity, especially for the synovitis and joint destruction in experimental arthritis. +transcription factor target 33864383 hsa-mir-147b Arthritis Also, mRNA sequencing data showed that hsa-miR-147b-3p mimic and ZNF148 siRNA commonly regulated the gene expression of CCL3 and DEPTOR as well as some arthritis and inflammation-related pathways. Taken together, miR-147b-3p contributes to synovial inflammation through repressing ZNF148 in RA and experimental arthritis. +circulation_biomarker_prognosis_ns 33864191 hsa-mir-767 Multiple Myeloma METHODS: Bone marrow (BM) plasma cells of 86 MM patients (during standard diagnostic procedures) and 30 healthy donors (HDs) (examination of the eligibility for BM transplantation) were obtained, among which circ_0000190 and miR +lncRNA target 33863546 hsa-mir-27a Osteosarcoma In summary, our findings report a new molecular mechanism for the miR-27a-3p-mediated Taxol resistance via targeting tumour suppressor, Fbxw7 in osteosarcoma. +transcription factor target 33863396 hsa-mir-223 Shock, Septic 3p may be regarded as promising targets for the diagnosis and treatment of SSAKI in the future. +transcription factor target 33863396 hsa-mir-29b Shock, Septic 3p may be regarded as promising targets for the diagnosis and treatment of SSAKI in the future. +transcription factor target 33863396 hsa-mir-223 Acute Kidney Injury 3p may be regarded as promising targets for the diagnosis and treatment of SSAKI in the future. +transcription factor target 33863396 hsa-mir-29b Acute Kidney Injury 3p may be regarded as promising targets for the diagnosis and treatment of SSAKI in the future. +other 33863336 hsa-mir-29b Spinal Cord Injuries Then a SCI-related ceRNA regulatory network including 8 mRNAs of IFNGR1, STAT2, CYBB, NFATC1, FCGR2B, HMOX1, TLR4, and HK2, a lncRNA of RGD1564534, and a miRNA of miR-29b-5p was constructed. Moreover, RGD1564534 may serve as ceRNA by competitively binding to miR-29b-5p to regulate the expression of 8 SCI-related mRNAs. +circulation_biomarker_diagnosis_down 33862668 hsa-mir-93 Tuberculosis, Pulmonary MATERIALS AND METHODS: Using two different references (U6 and miR-93), we compared the expression levels of potentially important microRNAs in serum of APT patients with healthy individuals using quantitative polymerase chain reaction (qPCR). +transcription factor target 33862560 hsa-mir-25 Uterine Cervical Neoplasms We conclude that inhibition of miR-25 may upregulate KLF4 expression and regulate cell proliferation and motility in cervical cancer. +circRNA target 33862456 hsa-mir-532 Carcinoma, Hepatocellular 3p, leading to the downregulation of RAB9A and inhibiting cell invasion of HCC cells. +other 33862403 hsa-mir-4299 Periodontitis RESULTS: The upregulation of miR-199a-5p and downregulation of miR-4299 in gingival tissue was associated with the presence of PD and RA (P < 0.05). +circulation_biomarker_diagnosis_up 33862403 hsa-mir-199a Periodontitis MiR-3198, miR-4299 level in GCF and miR-199a-5p level in plasma strongly correlated with PD, demonstrating significant diagnostic performance. +genetics_GWAS 33862181 hsa-mir-155 Leukemia, Myelogenous, Chronic, BCR-ABL Positive 5p.Three different strategies were employed, namely a network-based pipeline, a survival analysis and genetic screening method, and a simulation modeling approach, to assess the oncogenic role of hsa-miR +other 33862068 hsa-mir-155 Lymphoma, T-Cell, Cutaneous Preliminary data show that aggressive antibiotic therapy is associated with decreased Y-phosphorylated signal transducer and activator of transcription 5 and miR-155 expression in lesional skin in two patients with Sezary syndrome. +circulation_biomarker_diagnosis_ns 33860430 hsa-mir-21 Atherosclerosis We aim to investigate the expression levels of miR-17, miR-21, miR-27a, miR-106b, miR-222 and CHOP gene in circulation of atherosclerosis patients compared to healthy controls to establish a link between ER stress and atherosclerosis. miR-17, miR-21, miR-27a, miR-106b, miR-222 and CHOP were significantly differentially expressed in patients with atherosclerosis. +circulation_biomarker_diagnosis_ns 33860430 hsa-mir-17 Atherosclerosis We aim to investigate the expression levels of miR-17, miR-21, miR-27a, miR-106b, miR-222 and CHOP gene in circulation of atherosclerosis patients compared to healthy controls to establish a link between ER stress and atherosclerosis. miR-17, miR-21, miR-27a, miR-106b, miR-222 and CHOP were significantly differentially expressed in patients with atherosclerosis. +circulation_biomarker_diagnosis_ns 33860430 hsa-mir-222 Atherosclerosis We aim to investigate the expression levels of miR-17, miR-21, miR-27a, miR-106b, miR-222 and CHOP gene in circulation of atherosclerosis patients compared to healthy controls to establish a link between ER stress and atherosclerosis. miR-17, miR-21, miR-27a, miR-106b, miR-222 and CHOP were significantly differentially expressed in patients with atherosclerosis. +circulation_biomarker_diagnosis_ns 33860430 hsa-mir-106b Atherosclerosis We aim to investigate the expression levels of miR-17, miR-21, miR-27a, miR-106b, miR-222 and CHOP gene in circulation of atherosclerosis patients compared to healthy controls to establish a link between ER stress and atherosclerosis. miR-17, miR-21, miR-27a, miR-106b, miR-222 and CHOP were significantly differentially expressed in patients with atherosclerosis. +circulation_biomarker_diagnosis_ns 33860430 hsa-mir-27a Atherosclerosis We aim to investigate the expression levels of miR-17, miR-21, miR-27a, miR-106b, miR-222 and CHOP gene in circulation of atherosclerosis patients compared to healthy controls to establish a link between ER stress and atherosclerosis. miR-17, miR-21, miR-27a, miR-106b, miR-222 and CHOP were significantly differentially expressed in patients with atherosclerosis. +other 33860122 hsa-mir-122 Hepatitis B After transduction with a lentivirus-encoding microRNA-122, the cell line harboring the highest level of replicon RNA was selected and then treated with anti-HCV compounds to eliminate the replicon RNA. +genetics_overexpression_suppress 33860046 hsa-mir-223 Neuralgia, Postherpetic 3p overexpression (OV) or interference. +lncRNA target 33860034 hsa-mir-543 Intrauterine Adhesion OBJECTIVE: To explore the function of miR-543 in endometrial cells and the possible mechanism of regulating the occurrence and development of intrauterine adhesion. CONCLUSION: During the formation of intrauterine adhesions, the expression of CDH2, COL16A1, vimentin, and alpha-SMA may be inhibited by the high expression of miR-543, which may affect the degree of fibrosis and collagen content in the intrauterine adhesions, thereby inhibiting the occurrence and development of intrauterine adhesions. +genetics_overexpression_promote 33859925 hsa-mir-520a Carcinoma, Non-Small-Cell Lung Upregulation of RRM2 enhanced the malignant behaviors of NSCLCs, but the oncogenic effects of RRM2 were blocked upon miR-520a overexpression. +genetics_overexpression_suppress 33859750 hsa-mir-765 Endometrial Neoplasms RNA silencing or overexpressing and pharmacologic inhibitors were used to assess the functions of ERbeta/miR-765/PLP2/Notch axis in UCEC cell proliferation and invasion in vivo and in vitro. +exosome 33859745 hsa-mir-125b Acute Kidney Injury We demonstrate that MSC-exos ameliorate ischemic AKI and promote tubular repair by targeting the cell cycle arrest and apoptosis of TECs through miR-125b-5p/p53 pathway. +other 33859515 hsa-mir-21 Diabetic Nephropathies Methods: A total of 136 patients with type 2 DM and 25 healthy subjects were assessed in a cross-sectional study concerning urinary albumin: creatinine ratio (UACR), eGFR, biomarkers of podocyte damage (synaptopodin, podocalyxin) and of proximal tubule (PT) dysfunction (Kidney injury moleculeKIM-1, N-acetyl-D-glucosaminidase-NAG), urinary lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), nuclear-enriched abundant transcript 1 (NEAT1), myocardial infarction-associated transcript (MIAT), taurine-upregulated gene 1 (TUG1), urinary miRNA21, 124, 93, 29a. +other 33859149 hsa-mir-467f Brain Death RESULTS: An enhanced expression in canonical pathways related to inflammation and myocardial apoptosis was observed in BD induced group, with 2 miRNAs, miR-30a-3p, and miR-467f, correlating with the level of LV dysfunction observed after BD. +other 33859149 hsa-mir-467f Cardiomyopathies RESULTS: An enhanced expression in canonical pathways related to inflammation and myocardial apoptosis was observed in BD induced group, with 2 miRNAs, miR-30a-3p, and miR-467f, correlating with the level of LV dysfunction observed after BD. +other 33859055 hsa-mir-21 Pulmonary Fibrosis 5 p expression than those from other patients. +other 33859055 hsa-mir-21 Fibrosis 5 p expression than those from other patients. +other 33858489 hsa-mir-185 Glioma CONCLUSIONS: Our study identified the SRSF1/circATP5B/miR5p/HOXB5 feedback loop in GSCs. +transcription factor target 33858426 hsa-mir-665 lung squamous cell carcinoma Furthermore, miR-665 promoted LUSC cell proliferation through facilitating the Wnt5a/beta-catenin signaling pathway and restrained apoptosis via inhibiting Caspase-3 signaling pathway, whereas TRIM8 suppressed cell growth by repressing the Wnt5a/beta-catenin signaling pathway and induced apoptosis through activating Caspase-3 signaling pathway. +other 33858418 hsa-mir-145 Carcinoma, Hepatocellular Circular RNA hsa_circ_0003288 induces EMT and invasion by regulating hsa_circ_0003288/miR-145/PD-L1 axis in hepatocellular carcinoma. +circulation_biomarker_diagnosis_up 33858417 hsa-mir-126 Diabetes Mellitus, Type 1 5p was positively correlated with CXCR1/2, and with HbA1c whilst negatively correlated with circulating endothelial progenitor cells (CD34+CD133+CD45dim) and fibronectin adhesion assay in a combined group of T1DM patients and HCs; p=0.028 p=0.049 p=0.035 p=0.047 and p=0.004 respectively. +circulation_biomarker_diagnosis_up 33858417 hsa-mir-126 Cardiovascular Diseases 5p was positively correlated with CXCR1/2, and with HbA1c whilst negatively correlated with circulating endothelial progenitor cells (CD34+CD133+CD45dim) and fibronectin adhesion assay in a combined group of T1DM patients and HCs; p=0.028 p=0.049 p=0.035 p=0.047 and p=0.004 respectively. +circulation_biomarker_diagnosis_up 33858417 hsa-mir-126 Inflammation 5p was positively correlated with CXCR1/2, and with HbA1c whilst negatively correlated with circulating endothelial progenitor cells (CD34+CD133+CD45dim) and fibronectin adhesion assay in a combined group of T1DM patients and HCs; p=0.028 p=0.049 p=0.035 p=0.047 and p=0.004 respectively. +genetics_overexpression_promote 33858324 hsa-mir-192 Carcinoma, Hepatocellular Moreover, overexpression of miR-192 observably inhibited the proliferation and migration of HCC cells, while overexpression of lncRNA XIST showed an opposite effect. +transcription factor target 33858314 hsa-mir-129 Carcinoma, Non-Small-Cell Lung 5p into NSCLC cell lines markedly induced cell apoptosis, DNA injury, cell cycle arrest, and inhibited cell proliferation and colony formation. +circRNA target 33858297 hsa-mir-7 Thyroid Cancer, Papillary Taken together, silencing of circ-PSD3 hampered the proliferation and invasion of PTC cells via upregulating the inhibitory effect of miR +genetics_overexpression_promote 33857783 hsa-mir-28 Leukemia, Lymphocytic, Chronic, B-Cell CRNDE overexpression inhibited cell proliferation and promoted apoptosis via miR-28/NDRG2 axis in CLL. In conclusion, our data elaborated that CRNDE expression was regulated by DNA methylation, and the protective effect of CRNDE on CLL was attributed to the inhibition of proliferation in CLL via miR-28/NDRG2 axis. +other 33857584 hsa-mir-363 Kidney Diseases The obtained results suggest miR3p involvement in the pathophysiology of Cd-induced renal injury in humans and maybe considered for possible interventional therapeutic strategies for Cd-associated kidney damage. +exosome 33857573 hsa-mir-497 Ossification of Posterior Longitudinal Ligament Herein, this study evaluated the function of bone marrow mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) delivering miR +lncRNA target 33857357 hsa-mir-26a Cicatrix, Hypertrophic LncRNA NORAD/miR-26a could be a potential target for treating HS. +transcription factor target 33857171 hsa-mir-155 Anodontia pylori eradication, low-dose aspirin (LDA), non-steroidal anti-inflammatory drugs (NSAIDs) and proton-pump inhibitors (PPI) on modification of inflammatory mucosal miRNAs miR-155 and miR-223 in Helicobacter pylori-infected and non-infected subjects. +transcription factor target 33857171 hsa-mir-223 Anodontia pylori eradication, low-dose aspirin (LDA), non-steroidal anti-inflammatory drugs (NSAIDs) and proton-pump inhibitors (PPI) on modification of inflammatory mucosal miRNAs miR-155 and miR-223 in Helicobacter pylori-infected and non-infected subjects. +other 33857171 hsa-mir-155 Gastritis, Atrophic Daily LDA as well as regular NSAIDs showed no influence on miRNAs expression both in healthy subjects and patients, while regular PPI intake was associated with lower miR-155 expression in antrum of patients with chronic gastritis independent of density of neutrophils and mononuclear infiltrate. +other 33856606 hsa-mir-221 Leiomyosarcoma Considering the pulmonary samples, we observed a higher miRNA-221 and a lower miRNA-126 expression in the leiomyosarcoma. +other 33856606 hsa-mir-126 Leiomyosarcoma Considering the pulmonary samples, we observed a higher miRNA-221 and a lower miRNA-126 expression in the leiomyosarcoma. +transcription factor target 33856598 hsa-mir-34b Diabetes, Gestational These findings concluded that miR-34b-3p impaired HUVECs viability and migration in GDM by targeting PDK1, which might provide a novel perspective for the pathogenesis and underlying therapeutic target for GDM. +lncRNA target 33856498 hsa-mir-27a Pulmonary Arterial Hypertension Our results demonstrated that during the pathophysiology of PAH, miR-27a, PPARgamma, and ET-1 were cross-inhibited, which indicated that the miR-27a/PPARgamma/ET-1 signaling pathway was dysregulated; in addition, BST could competitively bind to ET-1 receptors and inhibit the miR-27a/PPARgamma/ET-1 signaling pathway, thereby delaying the proliferation of PASMCs and affecting the development of PAH. +genetics_overexpression_promote 33856490 hsa-mir-671 Stomach Neoplasms 5p inhibitors facilitated the proliferation of gastric cancer cells; however, knocking down LINC01207 and the overexpression of miR +transcription factor target 33856081 hsa-mir-138 Hamartoma Syndrome, Multiple 5p inhibits CS-induced apoptosis in testicular cells by targeting Caspase-3 through the Bcl-2 signaling pathway. +transcription factor target 33856081 hsa-mir-138 Testicular Diseases 5p inhibits CS-induced apoptosis in testicular cells by targeting Caspase-3 through the Bcl-2 signaling pathway. +other 33856026 hsa-mir-495 Acute Kidney Injury In conclusion, our findings suggested a novel therapeutic axis of SNHG14/miR3p/HIPK1 to treat sepsis-induced AKI. +target gene 33854971 hsa-mir-450a Stomach Neoplasms MiR-450a-5p Inhibits Gastric Cancer Cell Proliferation, Migration, and Invasion and Promotes Apoptosis via Targeting CREB1 and Inhibiting AKT/GSK-3β Signaling Pathway. +other 33854632 hsa-mir-141 Carcinoma, Non-Small-Cell Lung 3p and ZEB1/ZEB2 relationship. +other 33854632 hsa-mir-141 Colorectal Neoplasms 3p and ZEB1/ZEB2 relationship. +lncRNA target 33854621 hsa-mir-1229 Esophageal Squamous Cell Carcinoma To characterize the functions of hsa_circ_0000700 and miR-1229, ESCC cells were infected with hsa_circ_0000700-specific siRNA, miR-1229 mimics, and an inhibitor alone or in combination. +genetics_overexpression_suppress 33854606 hsa-mir-369 Carcinoma, Hepatocellular More importantly, the ZEB1 siRNA diminished the discrepancy of growth and metastasis capacity between miR-369 overexpression HCC cells and control cells. +genetics_overexpression_suppress 33854606 hsa-mir-369 Liver Neoplasms More importantly, the ZEB1 siRNA diminished the discrepancy of growth and metastasis capacity between miR-369 overexpression HCC cells and control cells. +target gene 33854603 hsa-mir-573 Pancreatic Neoplasms MiR-573 suppresses cell proliferation, migration and invasion via regulation of E2F3 in pancreatic cancer. +circulation_biomarker_diagnosis_ns 33854583 hsa-mir-1305 Multiple Myeloma Exosome-mediated secretion of miR-1305 in MM cells promoted oncogenic activity of hypoxic MM cells and high serum levels of exosomal miR-1305. +epigenetics 33854524 hsa-mir-375 Breast Neoplasms EZH2 is an upstream regulator of miR-375 through mediating the methylation of STAT3, while FOXO1 is a downstream target mRNA of miR-375 that activates the p53 signaling pathway to suppress BC development. +circulation_biomarker_prognosis_ns 33854485 hsa-mir-375 Thyroid cancer, medullary RESULTS: Circulating miR-375 levels were 101 times higher in the serum of patients with MTC than in all other patients and controls, with no overlap (P < 0.01). +target gene 33854376 hsa-mir-1182 Carcinoma, Non-Small-Cell Lung Circ_0001806 Promotes the Proliferation, Migration and Invasion of NSCLC Cells Through miR-1182/NOVA2 Axis. +genetics_knock down_suppress 33854374 hsa-mir-615 Esophageal Squamous Cell Carcinoma PDX1 overexpression counteracted the inhibitory impact of miR +target gene 33854373 hsa-mir-4449 Colorectal Neoplasms microR-4449 Promotes Colorectal Cancer Cell Proliferation via Regulation of SOCS3 and Activation of STAT3 Signaling. +target gene 33854372 hsa-mir-634 Breast Neoplasms LncRNA SNHG8 Serves as an Oncogene in Breast Cancer Through miR-634/ZBTB20 Axis. +target gene 33854371 hsa-mir-32 Carcinoma, Non-Small-Cell Lung MicroRNA-32 and MicroRNA-548a Promote the Drug Sensitivity of Non-Small Cell Lung Cancer Cells to Cisplatin by Targeting ROBO1 and Inhibiting the Activation of Wnt/β-Catenin Axis. +target gene 33854371 hsa-mir-548a Carcinoma, Non-Small-Cell Lung MicroRNA-32 and MicroRNA-548a Promote the Drug Sensitivity of Non-Small Cell Lung Cancer Cells to Cisplatin by Targeting ROBO1 and Inhibiting the Activation of Wnt/β-Catenin Axis. +target gene 33854370 hsa-mir-130a Lung Neoplasms miR-130a-Mediated KLF3 Can Inhibit the Growth of Lung Cancer Cells. +other 33854310 hsa-mir-193a Pulmonary Disease, Chronic Obstructive CONCLUSION: Circ-OSBPL2 contributed to the apoptosis, in fl ammation, and oxidative stress of HBECs in smoke-related COPD by miR-193a-5p/BRD4 axis, suggesting a novel insight on the pathogenesis of COPD and a potential therapeutic strategy for future clinic intervention in COPD. +genetics_overexpression_promote 33854217 hsa-mir-215 Prostatic Neoplasms Downregulation of miR-215 is correlated with overexpression of KDM1B in enzalutamide-resistant prostate cancer cells, which promotes AR-dependent AGR2 transcription and regulates the sensitivity to next generation AR-targeted therapy. +lncRNA target 33854048 hsa-mir-133b Esophageal Squamous Cell Carcinoma Taken together, our study reveals a positive feedback loop of THAP9-AS1/miR-133b/SOX4 to facilitate ESCC progression, providing a potential molecular target to fight against ESCC. +virus_miRNA 33853871 ebv-mir-BART9 Burkitt Lymphoma EBV miR-BART9 has roles in progression of the lytic cycle through one specific target, FOXO3. +other 33853871 hsa-mir-141 Epstein-Barr Virus Infections Here, we profiled the small RNAs in reactivated Burkitt lymphoma cells and identified several miRNAs, such as miR-141, that are induced upon BCR cross-linking. +genetics_knock down_promote 33853611 hsa-mir-340 Carcinoma, Renal Cell 5p was validated to be targeted by LINC00641 and knockdown of miR +genetics_knock down_promote 33853086 hsa-mir-570 Leukemia, Myeloid, Acute Our findings identified a novel regulatory mechanism in which exosome-mediated circ_0004136 knockdown restrained AML cell malignant progression at least partly through targeting the miR +genetics_overexpression_promote 33852805 hsa-mir-365a Sepsis miR-365a-3p overexpression mitigated sepsis-mediated myocardial injury by inhibiting MyD88-mediated NF-kappaB activation. +genetics_overexpression_promote 33852805 hsa-mir-365a Cardiomyopathies miR-365a-3p overexpression mitigated sepsis-mediated myocardial injury by inhibiting MyD88-mediated NF-kappaB activation. +genetics_knock down_promote 33851774 hsa-mir-129 Myocardial Reperfusion Injury Gain- and loss-function studies regarding miR-129 were implemented to figure out its roles in myocardial I/R injury. +lncRNA target 33851769 hsa-mir-222 AIDS-Related Complex Our present study demonstrated that increased expression of circZNF292 ameliorated H(2) O(2) -induced injury in HLE-B3 cells at least in part through the miR3p/E2F3 axis, highlighting a novel insight into the involvement of circRNAs in the pathogenesis of ARC. +genetics_overexpression_suppress 33850895 hsa-mir-665 Adenocarcinoma of Lung The results of luciferase reporter assay and bioinformatics analysis confirmed that circ-000881 served as a sponge for miR-665, and PRICKLE2 was a direct target of miR-665.Overexpression of miR-665 or silencing of PRICKLE2 abolished circ +lncRNA target 33850889 hsa-mir-27a Pulmonary Fibrosis In this study, we investigated the effect of GLP-1 on pulmonary fibrosis through the AMPK/microRNA-27a (miR-27a) pathway. CONCLUSIONS: MiR-27a plays an important regulatory role in diabetic pulmonary fibrosis. +genetics_overexpression_promote 33850885 hsa-mir-20b Osteosarcoma Importantly, miR-20b-5p overexpression inhibited OS cell proliferation, invasion, and migration. +lncRNA target 33850882 hsa-mir-138-1 Nasopharyngeal Carcinoma 1-3p is a small molecule that can modulate radiosensitivity in the radioresistant C666-IR and HK-1R NPC cell lines by inhibiting EMT and targeting CRIPTO to reduce the activation of the JAK2/STAT3 pathway. +other 33850858 hsa-mir-495 Spinal Cord Injuries METHODS: In this study, we speculated that miR-495 may regulate the expression of STAT3 in the processes of neuronal proliferation and apoptosis following spinal cord injury (SCI). +other 33850763 hsa-mir-590 Urinary Bladder Neoplasms In this network, Calcium Voltage-gated Channel Auxiliary Subunit Alpha2delta1 (CACNA2D1, P<0.001), domain containing engulfment adaptor1 (GULP1, P=0.001), latent transforming growth factor beta binding protein 1 (LTBP1, P=0.006), myosin light chain kinase (MYLK, P=0.001), serpin family E member 2 (SERPINE2, P=0.002), spectrin beta non-erythrocytic 2 (SPTBN2, P=0.047), and hsa-miR3p (P<0.001) significantly affected the prognosis of BC patients. +genetics_overexpression_promote 33850568 hsa-mir-20a Endometrial Neoplasms Furthermore, Jak1 was identified as a new direct target of miR-20a-5p, and Jak1 overexpression was demonstrated to reverse the effects of miR-20a-5p-mimic on EC cell proliferation, invasive ability and adhesion. +genetics_GWAS 33850557 hsa-mir-125b Cystic Fibrosis Furthermore, HO-1 and miR-125b may be used as prognostic markers explaining the wide CF phenotypic variability as an additional control level over the CFTR gene mutations. +lncRNA target 33850555 hsa-mir-451a Polycystic Ovary Syndrome The present study aimed to investigate whether microRNA (miR)-451a plays a role in polycystic ovary syndrome by regulating the biological function of ovarian granulosa cells and investigate the underlying molecular mechanism. Thus, the miR-451a/ATF2 axis may be a new potential target for the treatment of polycystic ovary syndrome. +target gene 33850546 hsa-mir-361 Carcinoma, Hepatocellular MicroRNA-361-5p induces hepatocellular carcinoma cell apoptosis and enhances drug sensitivity by targeting MAP3K9. +other 33850534 hsa-mir-450a Diabetes, Gestational In conclusion, The CC genotype of PTPRD rs56407701, which may be bound by miR-450a, may increase the susceptibility of Chinese Han females to GDM during pregnancy. +target gene 33850523 hsa-mir-4284 Carcinoma, Non-Small-Cell Lung Ultrasound-targeted microbubble destruction enhances the anti-tumor action of miR-4284 inhibitor in non-small cell lung cancer cells. +genetics_overexpression_promote 33850521 hsa-mir-363 Squamous Cell Carcinoma of Head and Neck 3p, and SSFA2 overexpression partially counteracted the inhibitory effects of miR +lncRNA target 33850295 hsa-mir-96 Osteoarthritis 5p expression, which results in targeting HIF-2alpha 3'-UTR sequences and inhibiting HIF-2alpha in murine cartilage tissue and chondrocytes. +circRNA target 33849596 hsa-mir-200b Osteoarthritis MiR-200b-3p could be sponged by circ_0116061, and its inhibitor could reverse the regulation of circ_0116061 silencing on the biological functions of OA chondrocytes. +transcription factor target 33849554 hsa-mir-490 Colorectal Neoplasms 3p can suppress cell viability and resistance to chemotherapy in colorectal cancer cells through targeting TNKS2. +genetics_overexpression_promote 33849377 hsa-mir-613 Carcinoma, Non-Small-Cell Lung In addition, PSMG3-AS1 overexpression reduced the inhibitory effects of miR-613 on NSCLC cell proliferation. +other 33849101 hsa-mir-27b Endometriosis BACKGROUND: To explore the effects of microRNA (miR)-27b-3p-mediated homeobox A10 (HOXA10) on the proliferation, migration, and invasion of endometriosis cells (hEM15A). +lncRNA target 33849089 hsa-mir-339 Coronary Disease CONCLUSIONS: Down-regulation miR-339 may be the new targets to treat CHD through Nrf2/FOXO3 targeting Sirt2, and miR-339 may be a potential biomarker of CHD. +genetics_overexpression_promote 33849031 hsa-mir-181a Parkinson Disease Overexpression of miR-181a-5p promoted the cognitive impairment and the release of inflammatory cytokines and reversed the neuroprotective effect of Cur. CONCLUSION: Cur has a protective effect on ISO-induced cognitive dysfunction, which may be achieved by regulating the expression of miR-181a-5p. +genetics_overexpression_promote 33849031 hsa-mir-181a Cognition Disorders Overexpression of miR-181a-5p promoted the cognitive impairment and the release of inflammatory cytokines and reversed the neuroprotective effect of Cur. CONCLUSION: Cur has a protective effect on ISO-induced cognitive dysfunction, which may be achieved by regulating the expression of miR-181a-5p. +lncRNA target 33848981 hsa-mir-150 Stomach Neoplasms MiRNA-150 inhibition also resulted in significant tumor volume reductions in vivo, suggesting the potential application of miRNA-150 inhibitors in GC therapy. +exosome 33848709 hsa-let-7c Multiple Myeloma Herein, we investigated macrophage polarization and angiogenesis in MM in vitro via exosome-derived miR-let-7c. Thus, exosomal miR-let-7c may be a reliable biomarker for early prediction of tumor progression and a promising therapeutic target for MM. +genetics_overexpression_suppress 33848686 hsa-mir-193a Acute Lung Injury OBJECTIVE: To explore the role of lncRNA ZFAS1-mediated miR-193a-3p in the regulation of inflammatory responses in rats with sepsis-induced acute lung injury (ALI). CONCLUSION: Overexpression of ZFAS1, possibly via targeting the expression of miR-193a-3p, could inhibit the apoptosis and ameliorate the inflammatory responses of ALI in sepsis. +genetics_overexpression_suppress 33848686 hsa-mir-193a Sepsis OBJECTIVE: To explore the role of lncRNA ZFAS1-mediated miR-193a-3p in the regulation of inflammatory responses in rats with sepsis-induced acute lung injury (ALI). CONCLUSION: Overexpression of ZFAS1, possibly via targeting the expression of miR-193a-3p, could inhibit the apoptosis and ameliorate the inflammatory responses of ALI in sepsis. +lncRNA target 33848670 hsa-mir-128 Esophageal Squamous Cell Carcinoma PVT1 promoted ESCC progression via the miR-128/ZEB1/E-cadherin axis. +transcription factor target 33848585 hsa-mir-24 Burkitt Lymphoma The target genes of miRNAs higher expressed in LB vs. LSL (miR +transcription factor target 33848585 hsa-mir-29b Leigh Disease The target genes of miRNAs higher expressed in LB vs. LSL (miR +transcription factor target 33848585 hsa-mir-126 Burkitt Lymphoma The target genes of miRNAs higher expressed in LB vs. LSL (miR +transcription factor target 33848585 hsa-mir-29b Burkitt Lymphoma The target genes of miRNAs higher expressed in LB vs. LSL (miR +transcription factor target 33848585 hsa-mir-726 Burkitt Lymphoma The target genes of miRNAs higher expressed in LB vs. LSL (miR +transcription factor target 33848585 hsa-mir-24 Leigh Disease The target genes of miRNAs higher expressed in LB vs. LSL (miR +transcription factor target 33848585 hsa-mir-726 Leigh Disease The target genes of miRNAs higher expressed in LB vs. LSL (miR +transcription factor target 33848585 hsa-mir-214 Leigh Disease The target genes of miRNAs higher expressed in LB vs. LSL (miR +transcription factor target 33848585 hsa-mir-214 Burkitt Lymphoma The target genes of miRNAs higher expressed in LB vs. LSL (miR +transcription factor target 33848585 hsa-mir-1788 Leigh Disease The target genes of the miRNAs higher in LSL (miR +transcription factor target 33848585 hsa-mir-126 Leigh Disease The target genes of miRNAs higher expressed in LB vs. LSL (miR +transcription factor target 33848585 hsa-mir-103 Leigh Disease The target genes of the miRNAs higher in LSL (miR +transcription factor target 33848585 hsa-mir-375 Leigh Disease The target genes of the miRNAs higher in LSL (miR +genetics_overexpression_promote 33847879 hsa-mir-144 Pulmonary Disease, Chronic Obstructive Our current study suggested that LOC729178 overexpression alleviated CSE-induced inflammatory injury in 16HBE cells at least in part by up-regulating PHLPP2 via sponging miR3p, providing a rationale for developing LOC729178 as a potential therapeutic agent against COPD. +lncRNA target 33847733 hsa-mir-6795 Carcinoma, Hepatocellular 5p/FMNL3 axis may be a novel therapeutic target for HCC. +other 33847647 hsa-mir-638 Digestive System Neoplasms Subgroup analysis found that low miR-638 expression was associated with worse OS in patients with digestive system cancer (HR = 2.47, 95% CI: 1.85-3.30, P < .001), the reported directly from articles group (HR = 2.12, 95% CI: 1.34-3.33, P < .001), survival curves group (HR = 2.02, 95% CI: 1.07-3.80, P = .029), in studies with sample size >/=100 (HR = 2.12, 95% CI: 1.34-3.35, P = .001), and in studies with sample size <100 (HR = 2.02, 95%CI: 1.09-3.75, P = .025). +other 33847647 hsa-mir-638 Carcinoma However, the prognostic value of miR-638 in human carcinomas is controversial and inconclusive. +circulation_biomarker_prognosis_ns 33847612 hsa-mir-449a Colorectal Neoplasms Low circulating miR-449a level also been demonstrated as an independent risk factor for CRC in multivariate COX analysis (HR, 2.56; 95%CI: 1.15-8.63; P < .05).Circulating miR-449a was significantly decreased in CRC patients and closely related to poor prognosis, suggesting that miR-449a might can be used as a useful diagnostic and prognostic marker for CRC. +exosome 33847133 hsa-mir-204 Carcinoma, Non-Small-Cell Lung In conclusion, the key findings of the current study demonstrate that exosomal miR-204 from MSCs possesses anticarcinogenic properties against NSCLC via the KLF7/AKT/HIF-1alpha axis. +other 33847014 hsa-mir-214 Pulmonary Fibrosis 1, and the presence of CARLo-5 and CD99P1 in HDAC1-LncRNAs coprecipitation products, but not HOTAIR. +other 33847014 hsa-mir-148b Pulmonary Fibrosis 1, and the presence of CARLo-5 and CD99P1 in HDAC1-LncRNAs coprecipitation products, but not HOTAIR. +other 33847014 hsa-mir-7-1 Pulmonary Fibrosis 1, and the presence of CARLo-5 and CD99P1 in HDAC1-LncRNAs coprecipitation products, but not HOTAIR. +other 33846991 hsa-mir-221 Myocardial Infarction Global microRNA (miRNA) expression analysis revealed that PBMT decreased miR-221, miR-34c, and miR-93 expressions post-MI, which are related to deleterious effects in cardiac remodeling. +other 33846991 hsa-mir-34c Myocardial Infarction Global microRNA (miRNA) expression analysis revealed that PBMT decreased miR-221, miR-34c, and miR-93 expressions post-MI, which are related to deleterious effects in cardiac remodeling. +other 33846991 hsa-mir-93 Myocardial Infarction Global microRNA (miRNA) expression analysis revealed that PBMT decreased miR-221, miR-34c, and miR-93 expressions post-MI, which are related to deleterious effects in cardiac remodeling. +transcription factor target 33846817 hsa-mir-485 Esophageal Squamous Cell Carcinoma In summary, miR4855p was found to be an inhibitor of ESCC and may have potential as a novel target candidate for ESCC treatment. +circulation_biomarker_prognosis_up 33846814 hsa-mir-105 Ovarian Neoplasms The stability and availability and ease in measurement of circulating hsamiR105 make it a valuable diagnostic/prognostic biomarker candidate for chemotherapy of EOC. +lncRNA target 33846812 hsa-mir-29b Triple Negative Breast Neoplasms The present results suggest that Vav1 is a crucial modulator of miR29b expression in breast tumor cells, and this finding may help identify strategies that may be useful in the management of TNBC by targeting the Vav1/miR29b axis, as there is a lack of molecularbased treatments for TNBC. +other 33846810 hsa-mir-524 Triple Negative Breast Neoplasms In conclusion, the present findings demonstrated that SChLAP1 modulated the malignant tumor behaviors of TNBC cells by regulating HMGA2 and subsequently restraining miR5245p. +other 33846809 hsa-mir-524 Pre-Eclampsia In the present study, quantitative PCR demonstrated that the expression levels of miR5245p were lower in patients with preeclampsia than those in normal pregnant women. +other 33846806 hsa-mir-654 Intervertebral Disc Degeneration The present study aimed to investigate the precise role and possible mechanism underlying the effects of miR6545p in the pathogenesis of IDD. The results demonstrated that miR6545p was significantly upregulated in degenerated NP tissues from patients with IDD and high miR6545p expression was positively associated with disc degeneration grade. +other 33846802 hsa-mir-44352 Squamous Cell Carcinoma of Head and Neck The lncRNA MIR44352 host gene (MIR44352HG) has been recently recognized as a tumorrelated lncRNA that is upregulated in several tumors. +lncRNA target 33846802 hsa-mir-383 Squamous Cell Carcinoma of Head and Neck Furthermore, MIR44352HG affected HNSCC cell proliferation and migration and EMT by modulating the microRNA miR3835p to positively regulate the protein expression level of RNAbinding motif protein 3 (RBM3). In conclusion, we provide a detailed analysis of the roles of MIR44352HG in HNSCC and identified the MIR44352HG/miR3835p/RBM3 axis as a potential therapeutic target for HNSCC treatment. +lncRNA target 33846796 hsa-mir-429 Erythema Multiforme The expression of microRNA (miR)429 is upregulated in EM and miR429 can be used as a target for drug regulation of cancer cells. Whether BBR plays a regulatory role in EM by targeting miR429 has not been reported. +lncRNA target 33846792 hsa-mir-29a Prolactinoma To conclude, miR29a3p inhibited the proliferation and secretory abilities of prolactinoma cells by inhibiting nuclear translocation of betacatenin via a molecular mechanism that is inseparable from IGF1. +genetics_knock down_suppress 33846791 hsa-mir-145 Urinary Bladder Neoplasms In addition, propofol induced miR1455p expression in a timedependent manner, and miR1455p knockdown attenuated the inhibitory effects of propofol on the proliferation, migration and invasion of BC cells. +lncRNA target 33846790 hsa-mir-20b Leukemia, Myeloid, Acute It was identified that LINC00460 may exert its effects, at least partly, via the miR320b/PBX3 axis in AML. +transcription factor target 33846769 hsa-mir-142 Epilepsy Taken together, the results of the present study demonstrated that miR142 inhibition promotes mitochondrial autophagy and reduces hippocampal damage in epileptic rats by targeting PINK1. +lncRNA target 33846539 hsa-mir-432 Osteosarcoma 5p mimic transfected MG63 and SaOS2 cells decreased cell viability, proliferation, migration, and aorta ring formation in endothelial cells. +transcription factor target 33846533 hsa-mir-155 Asthma Immunological, pathological and transcriptional analysis identified that miR5p or miR-99a-5p contribute significantly to HDM-driven AE and that transient inhibition of these miRNAs may provide relief from allergen-driven AE, without compromising anti-helminth immunity in the gut. +transcription factor target 33846533 hsa-mir-99a Asthma Immunological, pathological and transcriptional analysis identified that miR5p or miR-99a-5p contribute significantly to HDM-driven AE and that transient inhibition of these miRNAs may provide relief from allergen-driven AE, without compromising anti-helminth immunity in the gut. +genetics_knock down_promote 33846300 hsa-mir-185 Colorectal Neoplasms Our data provided evidence that knockdown of AGO2 resulted in a reduction of miR +circulation_biomarker_diagnosis_ns 33846102 hsa-mir-371a Neoplasms, Germ Cell, Malignant BACKGROUND: MicroRNAs from the miR-371~373 and miR-302/367 clusters, particularly miR-371a-3p, are promising biomarkers for blood-based diagnosis and disease monitoring of malignant germ cell tumors (GCTs) and are nearing clinical implementation. +circulation_biomarker_diagnosis_ns 33846102 hsa-mir-367 Neoplasms, Germ Cell, Malignant BACKGROUND: MicroRNAs from the miR-371~373 and miR-302/367 clusters, particularly miR-371a-3p, are promising biomarkers for blood-based diagnosis and disease monitoring of malignant germ cell tumors (GCTs) and are nearing clinical implementation. +circulation_biomarker_diagnosis_ns 33846102 hsa-mir-373 Neoplasms, Germ Cell, Malignant BACKGROUND: MicroRNAs from the miR-371~373 and miR-302/367 clusters, particularly miR-371a-3p, are promising biomarkers for blood-based diagnosis and disease monitoring of malignant germ cell tumors (GCTs) and are nearing clinical implementation. +circulation_biomarker_diagnosis_ns 33846102 hsa-mir-371 Neoplasms, Germ Cell, Malignant BACKGROUND: MicroRNAs from the miR-371~373 and miR-302/367 clusters, particularly miR-371a-3p, are promising biomarkers for blood-based diagnosis and disease monitoring of malignant germ cell tumors (GCTs) and are nearing clinical implementation. +target gene 33845844 hsa-mir-4428 Colonic Neoplasms LncRNA ACTA2-AS1 suppress colon adenocarcinoma progression by sponging miR-4428 upregulation BCL2L11. +other 33845782 hsa-mir-141 Atherosclerosis Among the top 20 up-regulated miRNAs, the expression levels of miR-200 family members (hsa-miR-200b/c-3p, miR3p and miR-429), which were rich in endothelial cells, were increased in EAT from CAD patients significantly. +other 33845782 hsa-mir-429 Atherosclerosis Among the top 20 up-regulated miRNAs, the expression levels of miR-200 family members (hsa-miR-200b/c-3p, miR3p and miR-429), which were rich in endothelial cells, were increased in EAT from CAD patients significantly. +transcription factor target 33845782 hsa-mir-200b Atherosclerosis CONCLUSIONS: Our study suggests that EAT derived miR-200b-3p promoted oxidative stress induced endothelial cells damage by targeting HDAC4, which may provide a new and promising therapeutic target for AS. +other 33845755 hsa-mir-483 Carcinoma, Ovarian Epithelial RESULTS: Among 2,578 mature human miRNAs, high expression of miR5p correlated with poor responses to platinum-based chemotherapy in EOC patients. +genetics_overexpression_suppress 33845716 hsa-mir-144 Adenocarcinoma of Lung Overexpressing miR +other 33845641 hsa-mir-497 Carcinoma, Hepatocellular 5p and upregulating BIRC5 expression. +circulation_biomarker_diagnosis_up 33845141 hsa-mir-141 Breast Neoplasms MEG3, which was mainly distributed in BC cytoplasm, could down-regulate miR +lncRNA target 33844975 hsa-mir-204 Retinoblastoma 5p could be sponged by circ-E2F3, and its inhibitor reversed the suppressive effect of circ-E2F3 silencing on RB progression. +circRNA target 33844960 hsa-mir-1 Polycystic Ovary Syndrome CONCLUSION: Circ-CARD6 promoted PCO development via miR-31/FGF7 axis. +lncRNA target 33844600 hsa-mir-146b Sarcoma, Ewing Our study revealed that miR-146b-5p affected the progression of ES by suppressing BTG2, which might shed light on anticancer drug development and ES treatment in the future. +lncRNA target 33844396 hsa-mir-670 Adenocarcinoma of Lung CONCLUSIONS: PP7080 expedites the proliferation and migration of LUAD cell via sponging miR +other 33844344 hsa-mir-876 limb ischemia Circ_0093887 was downregulated and miR3p was upregulated in AS patients and ox-LDL-treated HAECs. +other 33844344 hsa-mir-876 Atherosclerosis Circ_0093887 was downregulated and miR3p was upregulated in AS patients and ox-LDL-treated HAECs. +circulation_biomarker_diagnosis_up 33844160 hsa-mir-342 Carotid Stenosis And the upregulation of serum miR +circulation_biomarker_diagnosis_up 33844160 hsa-mir-342 Brain Ischemia And the upregulation of serum miR +lncRNA target 33843447 hsa-mir-27a Cerebral Infarction Circ_HECTD1 deficiency could mitigate OGD/R-induced HT22 cell damage by modulating the miR-27a-3p/FSTL1 axis, providing a promising therapeutic target for cerebral infarction treatment. +genetics_knock down_promote 33843021 hsa-mir-526b Carcinoma, Hepatocellular CONCLUSIONS: HOTAIR knockdown suppressed cell proliferation, migration and invasion, and promoted apoptosis via regulating miR-526b-3p/DHX33 axis in HCC cells, providing a potential avenue for treatment of HCC. +other 33842584 hsa-mir-23a Vascular System Injuries Therefore, we aim to explore the mechanism of how RUNX2 triggers the expression of miR-23a and its effects on the repair of vascular injury. +lncRNA target 33842488 hsa-mir-141 Carcinoma, Non-Small-Cell Lung 3p to regulate Hippo/YAP signalling pathway, thereby inhibiting NSCLC malignant transformation. +other 33842462 hsa-mir-200a Bronchopulmonary Dysplasia Among those EXO-miRNAs which are associated with PI3K/Akt and angiogenesis-related signaling pathways, BPD reduced the expression of hsa-miR-103a-3p and hsa-miR5p exhibiting the most significant reduction (14.3% and 23.1% of NBPD group, respectively); BPD increased hsa-miR-200a-3p expression by 2.64 folds of the NBPD group. +other 33842462 hsa-mir-185 Bronchopulmonary Dysplasia Among those EXO-miRNAs which are associated with PI3K/Akt and angiogenesis-related signaling pathways, BPD reduced the expression of hsa-miR-103a-3p and hsa-miR5p exhibiting the most significant reduction (14.3% and 23.1% of NBPD group, respectively); BPD increased hsa-miR-200a-3p expression by 2.64 folds of the NBPD group. +other 33842462 hsa-mir-103a Bronchopulmonary Dysplasia Among those EXO-miRNAs which are associated with PI3K/Akt and angiogenesis-related signaling pathways, BPD reduced the expression of hsa-miR-103a-3p and hsa-miR5p exhibiting the most significant reduction (14.3% and 23.1% of NBPD group, respectively); BPD increased hsa-miR-200a-3p expression by 2.64 folds of the NBPD group. +target gene 33842379 hsa-mir-671 Pancreatic Neoplasms CircRNA circ_0092314 Induces Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells via Elevating the Expression of S100P by Sponging miR-671. +other 33842368 hsa-mir-181d Leukemia, Myelogenous, Chronic, BCR-ABL Positive miR-181d/RBP2/NF-κB p65 Feedback Regulation Promotes Chronic Myeloid Leukemia Blast Crisis. +other 33842337 hsa-mir-1 Prostatic Neoplasms 3p had lower expression in the GG4 PCa cases. +other 33842337 hsa-mir-10a Prostatic Neoplasms 3p had lower expression in the GG4 PCa cases. +other 33842337 hsa-mir-423 Prostatic Neoplasms 3p had lower expression in the GG4 PCa cases. +transcription factor target 33842337 hsa-mir-27a Prostatic Neoplasms Cross referencing our differentially expressed miRNAs to two large prostate cancer datasets revealed that the putative tumor suppressors miR-1, miR-23b, and miR-27a are consistently deregulated in prostate cancer. +other 33842337 hsa-mir-27b Prostatic Neoplasms 3p had lower expression in the GG4 PCa cases. +transcription factor target 33842337 hsa-mir-23b Prostatic Neoplasms Cross referencing our differentially expressed miRNAs to two large prostate cancer datasets revealed that the putative tumor suppressors miR-1, miR-23b, and miR-27a are consistently deregulated in prostate cancer. +epigenetics 33842327 hsa-mir-216a Esophageal Neoplasms Demethylated miR-216a Regulates High Mobility Group Box 3 Promoting Growth of Esophageal Cancer Cells Through Wnt/β-Catenin Pathway. +exosome 33842319 hsa-mir-19a Osteosarcoma Osteosarcoma Cell-Derived Small Extracellular Vesicles Enhance Osteoclastogenesis and Bone Resorption Through Transferring MicroRNA-19a-3p. +other 33841707 hsa-mir-145 Uterine Cervical Neoplasms The expression level of miR-145 and miR-205 is correlated with HPV infection and cervical tumor malignancy. +other 33841707 hsa-mir-205 Uterine Cervical Neoplasms The expression level of miR-145 and miR-205 is correlated with HPV infection and cervical tumor malignancy. +circulation_biomarker_prognosis_ns 33841701 hsa-mir-151 Nephrotic Syndrome The serum miR +lncRNA target 33841686 hsa-mir-200c Laryngeal Neoplasms CONCLUSION: LINC01303 plays a carcinogenic part in LSCC carcinogenesis through regulating miR-200c/TIMP2 axis, which may become a promising target of LSCC therapy. +other 33841682 hsa-mir-378 Triple Negative Breast Neoplasms Both factors, miR-378 and, to a lesser extent, KLK4 mRNA represent unfavorable prognostic markers in TNBC patients. +other 33841662 hsa-mir-612 Adenocarcinoma of Lung LncRNA OSER1-AS1 interacts with miR-612/FOXM1 axis to modulate gefitinib resistance of lung adenocarcinoma. +lncRNA target 33841659 hsa-mir-873 Hemangioma, Cavernous In summary, our study suggests that circATP5SL promotes IH progression by regulating IGF1R expression through adsorption of miR5p, elucidating circATP5SL as a promising therapeutic target for the prognostication and treatment of IH. +circulation_biomarker_diagnosis_ns 33841653 hsa-mir-29a Osteoarthritis CONCLUSION: Intrathecal injection of umbilical cord blood mesenchymal stem cells can improve the pain and central sensitization of advanced osteoarthritis through LncRNA H19/microRNA-29a-3p/FOS axis. +target gene 33841651 hsa-mir-22 Lung Neoplasms MiR-22-3p suppresses cell growth via MET/STAT3 signaling in lung cancer. +lncRNA target 33841645 hsa-mir-107 Osteosarcoma Mechanistic investigation revealed that ZEB2-AS1 acted as a sponge for miR-107 and blocked the inhibition of spalt like transcription factor 4 (SALL4) via miR-107 in OS cells. Rescue experiments suggested that up-regulation of ZEB2-AS1 could partly attenuate the miR-107 mediated inhibition of SALL4 expression in OS cells. +other 33841642 hsa-mir-132 Carcinoma, Adenoid Cystic 5p were potential regulators in AdCC. +other 33841642 hsa-mir-29 Carcinoma, Adenoid Cystic 5p were potential regulators in AdCC. +genetics_overexpression_promote 33841640 hsa-mir-24 Subarachnoid Hemorrhage NC vector), miR-24 inhibitor (treated with miR-24 inhibitor vector), HMOX-NC (treated with HMOX1-NC vector), oe-HMOX1 (treated with HMOX1 overexpression vector), and miR-24 inhibitor si-HMOX1 (treated with miR-24 inhibitor and si-HMOX1 vectors) groups. +genetics_overexpression_promote 33841640 hsa-mir-24 Vasospasm, Intracranial NC vector), miR-24 inhibitor (treated with miR-24 inhibitor vector), HMOX-NC (treated with HMOX1-NC vector), oe-HMOX1 (treated with HMOX1 overexpression vector), and miR-24 inhibitor si-HMOX1 (treated with miR-24 inhibitor and si-HMOX1 vectors) groups. +other 33841638 hsa-mir-942 Pancreatic Carcinoma CONCLUSION: Our study provides experimental evidence for an interaction between SNHG17 and miR-942, which may unveil a new approach for PC pharmacotherapy. +genetics_overexpression_suppress 33841637 hsa-mir-340 Carcinoma, Hepatocellular CREB1 overexpression reversed the impact of miR +lncRNA target 33841635 hsa-mir-34a Uterine Cervical Neoplasms This study explored the synergistic effect of anti-PD-L1 antibody cationic microbubbles (MBs) for delivery of the miR-34a gene combined with ultrasound in inhibiting the cervical cancer. Firstly, PD-L1 Ab/miR-34a-MBs could gather miR-34a with high-concentration aggregation and releasing around the cervical cancer, which takes a significant role in promoting apoptosis by downregulated Bcl-2 and upregulated Bax. +exosome 33841631 hsa-mir-29b Inflammation BMSCs-exosomal H19 modulates LPS-stimulated microglial M1/M2 polarization and alleviates inflammation-mediated neurotoxicity by sponging miR-29b-3p. +target gene 33841580 hsa-mir-142 Stomach Neoplasms Upregulation of circRNA_100395 sponges miR-142-3p to inhibit gastric cancer progression by targeting the PI3K/AKT axis. +target gene 33841577 hsa-mir-211 Thyroid Neoplasms circCCDC66 promotes thyroid cancer cell proliferation, migratory and invasive abilities and glycolysis through the miR-211-5p/PDK4 axis. +genetics_knock down_promote 33841573 hsa-mir-203 Multiple Myeloma In conclusion, increased lnc-TCF7 expression was related to deteriorating clinical features and prognosis, and lnc-TCF7-knockdown inhibited disease progression by regulating the miR +genetics_knock down_promote 33841568 hsa-mir-32 Colorectal Neoplasms Levels of miR-32, TMEM245, PTEN and the proliferation and apoptosis of CRC cells were studied using FOXK1-overexpression or knockdown, or by simultaneously interfering with FOXK1 and miR-32 expression. +other 33841404 hsa-mir-155 Dermatitis Herpetiformis We showed that miR-155 significantly reduced the proliferation of aPBMCs in vitro and inflammation in vivo, using the DTH model. +transcription factor target 33841401 hsa-mir-497 Arthritis, Rheumatoid MiR-497 mimic, rather than miR-424 inhibitor, had significant effects on proliferation and apoptosis of RASF. +transcription factor target 33841401 hsa-mir-424 Arthritis, Rheumatoid MiR-497 mimic, rather than miR-424 inhibitor, had significant effects on proliferation and apoptosis of RASF. +lncRNA target 33841015 hsa-mir-155 Vascular Diseases CONCLUSION: KRGE delayed or prevented HUVEC senescence through a signaling cascade involving the induction of HO-1, the inhibition of NF-kappaB-dependent miR5p biogenesis, and the maintenance of the eNOS/NO axis activity, suggesting that it may protect against vascular diseases associated with endothelial senescence. +lncRNA target 33841015 hsa-mir-155 Aging, Premature CONCLUSION: KRGE delayed or prevented HUVEC senescence through a signaling cascade involving the induction of HO-1, the inhibition of NF-kappaB-dependent miR5p biogenesis, and the maintenance of the eNOS/NO axis activity, suggesting that it may protect against vascular diseases associated with endothelial senescence. +lncRNA target 33840587 hsa-mir-29a Sepsis CONCLUSION: PVT1 promoted M1 polarization and aggravated LPS induced myocardial injury via miR-29a/HMGB1 axis. +lncRNA target 33840587 hsa-mir-29a Cardiomyopathies CONCLUSION: PVT1 promoted M1 polarization and aggravated LPS induced myocardial injury via miR-29a/HMGB1 axis. +circulation_biomarker_prognosis_up 33840258 hsa-mir-23b Stomach Neoplasms Then, circNFATC3 had a co-localization with miR-23b-3p in the cytoplasm in GC tissue cells and could act as a sponge of miR-23b-3p in GC cell line. +genetics_knock down_promote 33840153 hsa-mir-3 Ataxia Neuropathy Spectrum RESULTS: We found that loss of miR-33 predisposes flies to elevated TAG levels, and we identified genes involved in TAG synthesis as direct targets of miR-33, including atpcl, midway, and Akt1. +lncRNA target 33840148 hsa-mir-15 Slow Virus Diseases 5p is beneficial for RBSDV infection in its insect vector by directly targeting a melatonin receptor. +circulation_biomarker_diagnosis_ns 33840057 hsa-mir-155 Toxoplasmosis CONCLUSION: miRNA-155 and BChE play a role in regulating host-parasite interaction in toxoplasmosis and may contribute to the pathogenesis of T. +other 33840048 hsa-mir-483 Breast Neoplasms Moreover, we identify frequency-based biomarkers (hsa-miR-410, hsa-miR5p) and network-based biomarkers (hsa-miR-454, hsa-miR-137) which we validate to have strong connectivity with breast cancer. +other 33840048 hsa-mir-137 Breast Neoplasms Moreover, we identify frequency-based biomarkers (hsa-miR-410, hsa-miR5p) and network-based biomarkers (hsa-miR-454, hsa-miR-137) which we validate to have strong connectivity with breast cancer. +other 33840048 hsa-mir-410 Breast Neoplasms Moreover, we identify frequency-based biomarkers (hsa-miR-410, hsa-miR5p) and network-based biomarkers (hsa-miR-454, hsa-miR-137) which we validate to have strong connectivity with breast cancer. +genetics_overexpression_promote 33839982 hsa-mir-26b Reperfusion Injury, Intestinal Ischemia We additionally found miR-26b-5p overexpression to markedly disrupt intestinal I/R- or OGD/R-induced injury in vivo and in vitro, whereas inhibiting this miRNA had an adverse impact and resulted in increased intestinal tissue injury and Mode-K cell damage. +other 33839577 hsa-mir-194 Reperfusion Injury, Hepatic Ischemia PHLDA1 was upregulated in hepatic IRI with a concomitant downregulation of miR-194. In conclusion, the miR-194/PHLDA1 axis was a key upstream regulator of IKK and MAPK in hepatic IRI. +genetics_knock down_suppress 33839417 hsa-mir-497 Hemangioma Taken together, our results suggested that knockdown of long non-coding RNA MEG8 inhibited the proliferation and induced the ferroptosis of hemangioma endothelial cells by regulating miR5p/NOTCH2 axis. +lncRNA target 33839325 hsa-mir-22 Carcinoma, Hepatocellular We reveal a novel regulatory mode by which the TRERNA1/miR3p/NRAS axis mediates HCC progression and indicates that TRERNA1 might constitute a powerful tumor biomarker and therapeutic target in HCC. +genetics_overexpression_promote 33839256 hsa-mir-223 Prostatic Hyperplasia 3p overexpression in BPH-1 cell phenotypes, pro-apoptotic Bax/caspase 3, and the EMT and MAPK signaling pathways under TGF-beta stimulation. +other 33838342 hsa-mir-431 Diabetic Retinopathy 5p was involved in the pathogenesis of PDR development and may function as a novel biomarker for PDR. +lncRNA target 33838155 hsa-mir-663 Carcinoma, Hepatocellular Overall, our data suggest that baicalein may act as a novel HCC suppressor, and that the miR +circulation_biomarker_prognosis_up 33838016 hsa-mir-140 Colorectal Neoplasms Here, we demonstrated that the level of plasma exosomal miR +circulation_biomarker_prognosis_ns 33837901 hsa-mir-126 Carcinoma, Non-Small-Cell Lung Circulating miR +circulation_biomarker_prognosis_ns 33837901 hsa-mir-21 Carcinoma, Non-Small-Cell Lung Circulating miR +lncRNA target 33837882 hsa-mir-1253 Colonic Neoplasms MiR-1253 was identified as a prognostic biomarker and a tumor suppressor of colon cancer. +genetics_knock down_promote 33837793 hsa-mir-432 Neuroblastoma The suppression of NOL4L knockdown on NB cells progression could be rescued by miR +other 33837645 hsa-mir-135a Muscular Diseases In conclusion, our study identified a crucial role of lnc-MFAT1-miR-135a-Tgfbr2/Smad4 axis in skeletal muscle fibrosis, providing a promising treatment option against skeletal muscle fibrosis. +lncRNA target 33837611 hsa-mir-516b Osteosarcoma Taken together, LINC01123 enhances OS proliferation and metastasis via the miR-516b-5p/Gli1 axis. +transcription factor target 33837492 hsa-mir-499a Reperfusion Injury, Cerebral Ischemia These findings suggest that miR-499a-5p might represent a novel target that regulates brain injury by inhibiting PDCD4-mediating apoptosis. +lncRNA target 33837411 hsa-mir-20a Hypertrophy Also, miR-20a-5p attenuated the cardiac fibrosis demonstrated by decreased transforming growth factor-beta1, collagen I levels and the inflammatory response manifested by reduced interleukin-6, tumour necrosis factor-alpha and IL-1beta production. Overall, miR-20a-5p may effectively ameliorate DCM through improving cardiac metabolism, and subsequently inhibiting inflammation, apoptosis, hypertrophy, fibrosis and JNK/NF-kappaB pathway via modulating ROCK2. +lncRNA target 33837411 hsa-mir-20a Diabetic Cardiomyopathies Also, miR-20a-5p attenuated the cardiac fibrosis demonstrated by decreased transforming growth factor-beta1, collagen I levels and the inflammatory response manifested by reduced interleukin-6, tumour necrosis factor-alpha and IL-1beta production. Overall, miR-20a-5p may effectively ameliorate DCM through improving cardiac metabolism, and subsequently inhibiting inflammation, apoptosis, hypertrophy, fibrosis and JNK/NF-kappaB pathway via modulating ROCK2. +circulation_biomarker_diagnosis_up 33836917 hsa-mir-140 Familial Primary Pulmonary Hypertension RESULTS: Among MD-related miRNAs, the circulating levels of miR +other 33836917 hsa-mir-485 Familial Primary Pulmonary Hypertension The miR5p levels in the CTEPH group correlated with right atrium pressure (r = -0.456, p = 0.049). +genetics_GWAS 33836616 hsa-mir-16 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Moreover, BC CMLs showed an overexpression of miR-15/16 direct targets such as Bmi-1, ROR1, and Bcl-2 compared to CMLs in chronic phase. +genetics_GWAS 33836616 hsa-mir-15b Leukemia, Myelogenous, Chronic, BCR-ABL Positive Considering the key role of miR-15/16 loci in the pathogenesis of myeloid and lymphocytic leukemia, here we aimed to correlate the expression of miR-15a/16 and miR-15b/16 to progression of CML from chronic phase to BC. +genetics_GWAS 33836616 hsa-mir-15 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Moreover, BC CMLs showed an overexpression of miR-15/16 direct targets such as Bmi-1, ROR1, and Bcl-2 compared to CMLs in chronic phase. +genetics_GWAS 33836616 hsa-mir-15a Leukemia, Myelogenous, Chronic, BCR-ABL Positive Considering the key role of miR-15/16 loci in the pathogenesis of myeloid and lymphocytic leukemia, here we aimed to correlate the expression of miR-15a/16 and miR-15b/16 to progression of CML from chronic phase to BC. +circulation_biomarker_diagnosis_up 33836533 hsa-mir-141 Pneumonia SNHG16 and sushi domain containing 2 (SUSD2) were upregulated, and miRNA (miR)3p was downregulated in the serum of acute pneumonia patients and lipopolysaccharide (LPS)-challenged human lung fibroblasts WI-38. +genetics_knock down_promote 33836345 hsa-mir-125b Ovarian Neoplasms Intriguingly, MKNK2 knockdown-suppressed cell proliferation and -induced autophagy were almost abrogated by miR-125b inhibition in chemoresistant ovarian cancer cells. +transcription factor target 33836263 hsa-mir-145 Hepatorenal Syndrome Dioscin relieved MTX-induced hepatorenal damages through regulating miR +circulation_biomarker_diagnosis_ns 33836245 hsa-mir-4422 Alzheimer Disease 5p had a reduced level in the serum of AD patients. +circulation_biomarker_diagnosis_down 33835684 hsa-mir-18b Pre-Eclampsia EV-derived miR-18b or Notch2 down-regulation enhanced trophoblast proliferation and migration in vitro and decreased blood pressure and 24 hours urinary protein in PE rats by deactivating the TIM3/mTORC1 axis in vivo. +other 33835671 hsa-mir-17 Nephritis Nonetheless, the biological function and molecular mechanism of miR5p are unclear in nephritis. +circRNA target 33835399 hsa-mir-155 Epilepsy Our data revealed that circUBQLN1 prevented nerve injury in Mg(2+)-free-treated HN-h cells by regulating the miR-155/SOX7 axis, showing that circUBQLN1 might be used as a biomolecular target for the treatment of epilepsy. +tissue_expression_up 33834642 hsa-mir-1913 Prostatic Neoplasms Here, we evaluated the diagnostic value of urinary miR-1913 to miR-3659 ratio in PCa patients and benign prostate hyperplasia (BPH) controls. The urinary miR-1913 to miR-3659 expression ratio was selected and tested in 83 urine samples (44 PCa and 39 BPH) to confirm its validity as a non-invasive diagnostic biomarker for PCa. RESULTS The expression ratio of urinary miR-1913 to miR-3659 was significantly higher in PCa than in BPH (p=0.002) and showed a higher area under the receiver operating characteristic curve than prostate-specific antigen (PSA; 0.821 vs. CONCLUSIONS The urinary miR-1913 to miR-3659 expression ratio was increased in PCa and may serve as a useful supplemental biomarker to PSA for the diagnosis of PCa, particularly in patients within the PSA gray zone. +tissue_expression_up 33834642 hsa-mir-659 Prostatic Neoplasms Here, we evaluated the diagnostic value of urinary miR-1913 to miR-3659 ratio in PCa patients and benign prostate hyperplasia (BPH) controls. The urinary miR-1913 to miR-3659 expression ratio was selected and tested in 83 urine samples (44 PCa and 39 BPH) to confirm its validity as a non-invasive diagnostic biomarker for PCa. RESULTS The expression ratio of urinary miR-1913 to miR-3659 was significantly higher in PCa than in BPH (p=0.002) and showed a higher area under the receiver operating characteristic curve than prostate-specific antigen (PSA; 0.821 vs. CONCLUSIONS The urinary miR-1913 to miR-3659 expression ratio was increased in PCa and may serve as a useful supplemental biomarker to PSA for the diagnosis of PCa, particularly in patients within the PSA gray zone. +exosome 33834074 hsa-mir-1307 Osteosarcoma In conclusion, our study suggests that OS cell-derived exosomal miR-1307 promotes the proliferation, migration, and invasion of OS cells via targeting AGAP1, and miR +circulation_biomarker_diagnosis_up 33833996 hsa-mir-20a Carcinoma, Non-Small-Cell Lung Circulating miR-320a Acts as a Tumor Suppressor and Prognostic Factor in Non-small Cell Lung Cancer. +other 33833823 hsa-mir-1306 Colorectal Neoplasms In conclusion, LINC00857 can promote colorectal cancer progress by sponging miR-1306 and upregulate vimentin to accelerate the epithelial-mesenchymal transition process. +lncRNA target 33833666 hsa-mir-184 Brain Injuries In summary, our results reveal that attenuation of miR-184 levels in ischemic stroke contributes to ischemic injury through targeting PPAP2B mRNA-mediated apoptosis, which may be a promising therapeutic target for ischemic stroke. +lncRNA target 33833666 hsa-mir-184 Ischemic Stroke In summary, our results reveal that attenuation of miR-184 levels in ischemic stroke contributes to ischemic injury through targeting PPAP2B mRNA-mediated apoptosis, which may be a promising therapeutic target for ischemic stroke. +other 33833661 hsa-mir-34a Alzheimer Disease 3p in the STG. +other 33833661 hsa-mir-146a Alzheimer Disease 3p in the STG. +other 33833661 hsa-mir-501 Alzheimer Disease 3p in the STG. +other 33833661 hsa-mir-454 Alzheimer Disease 3p in the STG. +other 33833661 hsa-mir-212 Alzheimer Disease 3p in the STG. +other 33833661 hsa-mir-132 Alzheimer Disease 3p in the STG. +other 33833618 hsa-mir-6501 COVID-19 5p/STAT3 axis, which may also play an important role in the development of ground-glass opacity in COVID-19 patients. +other 33833618 hsa-mir-29b-2 COVID-19 5p/STAT3 axis, which may also play an important role in the development of ground-glass opacity in COVID-19 patients. +other 33833618 hsa-mir-20a COVID-19 5p/STAT3 axis, which may also play an important role in the development of ground-glass opacity in COVID-19 patients. +circRNA target 33833580 hsa-mir-590 Carcinoma, Hepatocellular CONCLUSION: Our results suggest that circEPB41L2 might function as a tumor suppressor during HCC progression by sponging miR5p. +genetics_knock down_promote 33833571 hsa-mir-515 Urinary Bladder Neoplasms circCEP128 Knockdown Suppresses Bladder Cancer Progression via Regulating microRNA-515-5p/SDC1 Axis. +other 33833559 hsa-mir-135b Biliary Tract Neoplasms MiR-10a, miR-21, miR-135b and miR-214 can be used as biomarkers for the diagnosis of biliary diseases. +other 33833559 hsa-mir-214 Biliary Tract Neoplasms MiR-10a, miR-21, miR-135b and miR-214 can be used as biomarkers for the diagnosis of biliary diseases. +other 33833559 hsa-mir-10a Biliary Tract Neoplasms MiR-10a, miR-21, miR-135b and miR-214 can be used as biomarkers for the diagnosis of biliary diseases. +other 33833559 hsa-mir-21 Biliary Tract Neoplasms MiR-10a, miR-21, miR-135b and miR-214 can be used as biomarkers for the diagnosis of biliary diseases. +circulation_biomarker_diagnosis_ns 33833530 hsa-mir-42 Adenocarcinoma of Lung CONCLUSION: Serum exosomal miRNA (hsa-miR +circulation_biomarker_diagnosis_ns 33833530 hsa-mir-42 Carcinoma, Non-Small-Cell Lung CONCLUSION: Serum exosomal miRNA (hsa-miR +circulation_biomarker_diagnosis_ns 33833530 hsa-mir-483 Carcinoma, Non-Small-Cell Lung CONCLUSION: Serum exosomal miRNA (hsa-miR +circulation_biomarker_diagnosis_ns 33833530 hsa-mir-483 Adenocarcinoma of Lung CONCLUSION: Serum exosomal miRNA (hsa-miR +target gene 33833529 hsa-mir-944 Colorectal Neoplasms miR-944 Suppresses EGF-Induced EMT in Colorectal Cancer Cells by Directly Targeting GATA6. +other 33833526 hsa-mir-20a Squamous Cell Carcinoma of Head and Neck CONCLUSION: Taken together, LINC00460 mediates miR-320a/BGN signaling axis to promote cell proliferation, migration, invasion, and induce the EMT process in HNSCC cells. +circRNA target 33833509 hsa-mir-145 Hamartoma Syndrome, Multiple CONCLUSION: CircANKRD11 absence protected HPMECs from CSE-induced injury by regulating BRD4 through associating with miR +circRNA target 33833509 hsa-mir-145 Pulmonary Disease, Chronic Obstructive CONCLUSION: CircANKRD11 absence protected HPMECs from CSE-induced injury by regulating BRD4 through associating with miR +other 33833398 hsa-mir-129 Melanoma 5p/AGO2 miRISC act antagonistically to fine-tune PMEPA1 expression toward the progression of melanoma. +other 33833339 hsa-mir-130a Squamous Cell Carcinoma of Head and Neck Taken together, the findings of the study indicate that miR-130a-mediated TSC1 downregulation is not only a novel mechanism in OSCC, but also the restoration of TSC1 levels by antagomiR-130a may be a potential therapeutic strategy for the treatment of OSCC. +other 33833130 hsa-mir-370 Choroidal Neovascularization Increased miR-370 could mimic the effects of IPW silencing on CNV formation and endothelial angiogenic phenotypes in vivo and in vitro. +circulation_biomarker_diagnosis_ns 33832593 hsa-mir-181 Coronary Disease Furthermore, this assay was successfully applied to the detection of exosomal miR-181 in serum samples of normal healthy controls and patients with coronary heart disease (CHD) and the results were consistent with those analysis collected from qRT-PCR. +lncRNA target 33832517 hsa-mir-195 Glioblastoma CONCLUSION: OXCT1-AS1 inhibits glioma progression by regulating the miR5p/CDC25A axis and is a specific tumour marker and a novel potential therapeutic target for glioma treatment. +lncRNA target 33832516 hsa-mir-433 Pancreatic Carcinoma 3p inhibitors hindered circ-MBOAT2 silencing-mediated impacts on pancreatic cancer progression and glutamine catabolism. +other 33832120 hsa-mir-129 Colonic Neoplasms Furthermore, new pathways such as LINC00114/miR-107/PCKS5, UCA1/miR-107/PCKS5, and UCA1/miR5p/SEMA6A were identified.Two novel lncRNAs (LINC00114 and UCA1) in colon cancer were identified by bioinformatics analysis. +other 33832120 hsa-mir-107 Colonic Neoplasms Furthermore, new pathways such as LINC00114/miR-107/PCKS5, UCA1/miR-107/PCKS5, and UCA1/miR5p/SEMA6A were identified.Two novel lncRNAs (LINC00114 and UCA1) in colon cancer were identified by bioinformatics analysis. +transcription factor target 33832090 hsa-mir-137 Triple Negative Breast Neoplasms In this study, we investigated miR-496 and miR-137 as regulators of Del-1 expression in triple negative breast cancer (TNBC). Our findings suggest that miR-496 and miR-137 additively target Del-1 and act as modulating factors in TNBC. +genetics_knock down_promote 33831787 hsa-mir-656 Carcinoma, Hepatocellular 3p was verified by dual-lucifer- ase reporter assay.The role of circBACH1 was validated by xenograft assay.CircBAC- H1 and SERBP1 were upregulated in HCC tissues and cells.Both circBACH1 and SERBP1 knockdown constrained proliferation, migration, invasion, and EMT(epithel-ial-mesenchymal transition), and facilitated apoptosis of HCC cells in vitro.Knockdo-wn of circBACH1 reduced HCC growth in vivo. +lncRNA target 33831733 hsa-mir-29a Squamous Cell Carcinoma of Head and Neck Inhibition of miR-29a promoted, while silencing of MCL-1 suppressed the malignant behaviors of OSCC stem cells. +genetics_knock down_promote 33831429 hsa-mir-146b Colorectal Neoplasms The miR-146b-3p overexpression also enhanced the effects of SP1 overexpression on CRC cell proliferation, migration, and invasion, whereas miR-146b-3p knockdown led to the opposite results. +other 33831356 hsa-mir-93 Carcinoma, Hepatocellular Interference of miR-93 sensitizes hepatoma cells to cisplatin or sorafenib treatment. Clinical cohort analysis showed that Hepatocellular carcinoma (HCC) patients with low miR-93 were benefit more from TACE or sorafenib treatment. +circulation_biomarker_diagnosis_up 33830643 hsa-mir-155 Myocarditis CONCLUSIONS: The present data suggest that plasma levels of miR-206 and miR-155 are potential novel biomarkers for confirming the diagnosis of iCMP. +circulation_biomarker_diagnosis_up 33830643 hsa-mir-206 Myocarditis CONCLUSIONS: The present data suggest that plasma levels of miR-206 and miR-155 are potential novel biomarkers for confirming the diagnosis of iCMP. +genetics_GWAS 33830627 hsa-mir-146a Alzheimer Disease In this work, we investigated the regulatory effects of lncRNA of LINC01311 and its competing endogenous RNA target of hsa-miR-146a-5p in a cellular model of Alzheimer's disease (AD). Our work demonstrated that the epigenetic axis of LINC01311/hsa-miR-146a-5p was involved in the functional regulation of human-lineage neurons in a cellular model of AD, thus suggesting a clinical potential of exploring epigenetic network for treating AD patients. +genetics_overexpression_promote 33830472 hsa-mir-431 Lymphoma, Large B-Cell, Diffuse 5p inhibitor could reverse the suppressive effect of circ_OTUD7A silencing on DLBCL progression, and FOXP1 overexpression also could reverse the inhibitory effect of miR +other 33830082 hsa-mir-122 Lung Diseases Higher miR-122 expression was associated with worse clinical outcomes, highlighting the potential use of anti-miR-122 oligonucleotides, successfully trialed for treatment of hepatitis C, as potential therapeutics for RV-induced bronchiolitis and asthma exacerbations. +epigenetics 33829656 hsa-mir-448 Carcinoma, Hepatocellular KDM5B demethylated H3K4me3 on the miR-448 promoter and thereby inhibited the expression of miR-448, which in turn targeted YTHDF3 and integrin subunit alpha 6 (ITGA6) to promote the malignant phenotype of HCC. +genetics_knock down_promote 33829443 hsa-mir-508 Lymphoma, Large B-Cell, Diffuse 3p overexpression repressed DLBCL cell growth and metastasis, while PCAT1 overexpression reversed the inhibitory effect of miR +other 33829439 hsa-mir-486 Prostatic Neoplasms 5p/GOLPH3 axis in the PCa progression. +lncRNA target 33829438 hsa-mir-508 Osteosarcoma 3p/ZEB1 might serve as candidate therapeutic targets for OS patients. +genetics_overexpression_promote 33829382 hsa-mir-582 Fetal Membranes, Premature Rupture 5p reverses the pro-tumor effects of NEAT1 overexpression. +transcription factor target 33828590 hsa-mir-93 Leukemia, Myeloid, Acute 5p targeted and AML-related genes by integrating the results of multiple databases and then used the expression profile of TCGA-LAML to construct a coexpression function network of AML WGCNA. +transcription factor target 33828078 hsa-mir-155 high grade glioma 3p may be novel biomarkers for diagnosing glioma and that treatments targeting autophagy and the STAT3 pathway may contribute to antitumor immunotherapy. +other 33828067 hsa-mir-335 Bone Diseases MiRNAs such as miRNA-218, miRNA-335, miRNA-29, microRNA-30 and other miRNAs exert negative or positive effects on some crucial molecules in the Wnt/ss-catenin pathway, which in turn affect bone metabolism and osteopathy. +other 33828067 hsa-mir-29 Bone Diseases MiRNAs such as miRNA-218, miRNA-335, miRNA-29, microRNA-30 and other miRNAs exert negative or positive effects on some crucial molecules in the Wnt/ss-catenin pathway, which in turn affect bone metabolism and osteopathy. +other 33828067 hsa-mir-218 Bone Diseases MiRNAs such as miRNA-218, miRNA-335, miRNA-29, microRNA-30 and other miRNAs exert negative or positive effects on some crucial molecules in the Wnt/ss-catenin pathway, which in turn affect bone metabolism and osteopathy. +other 33828027 hsa-mir-221 Osteosarcoma Therefore, the present study aimed to investigate the role and underlying mechanism of miRNA-221 in doxorubicin (DOX) resistance in osteosarcoma cells. Thus, miRNA-221 increased the expression of P-gp and Bcl-2 by activating the Stat3 pathway to promote DOX resistance in osteosarcoma cells, indicating a potential use of miRNA-221 in osteosarcoma treatment. +genetics_overexpression_promote 33827350 hsa-mir-155 Liver Neoplasms Finally, the overexpression of miR-155 inhibits malignant biological behavior of human liver cancer cells. +circulation_biomarker_diagnosis_ns 33827323 hsa-mir-494 Depressive Disorder, Major METHODS: We performed a pilot study analyzing the differential expression of miR-26a, miR-494, miR-30c, miR-93, and miR-101 and investigated their levels in white blood cells, total plasma (TP), exosomes from plasma, and exosome depleted plasma (EDP) in patients with MDD before and after antidepressant treatment with escitalopram and in healthy controls. +circulation_biomarker_diagnosis_ns 33827323 hsa-mir-93 Depressive Disorder, Major METHODS: We performed a pilot study analyzing the differential expression of miR-26a, miR-494, miR-30c, miR-93, and miR-101 and investigated their levels in white blood cells, total plasma (TP), exosomes from plasma, and exosome depleted plasma (EDP) in patients with MDD before and after antidepressant treatment with escitalopram and in healthy controls. +genetics_GWAS 33826889 hsa-mir-29 Mental Disorders Deletion of miR-29 in the brain, or knockin mutations preventing miR-29 to specifically target Dnmt3a, result in increased DNMT3A expression, higher CH methylation, and repression of genes associated with neuronal activity and neuropsychiatric disorders. +transcription factor target 33826679 hsa-mir-206 Granuloma Here we examine the role of miR-206 in the zebrafish model of Mycobacterium marinum infection, which allows investigation of the early stages of granuloma formation. Together, our data illustrate a pathway through which pathogenic mycobacteria induce host miR-206 expression to suppress Cxcl12/Cxcr4 signalling and prevent protective neutrophil recruitment to granulomas. +other 33826281 hsa-mir-93 Colorectal Neoplasms 5p expression. +lncRNA target 33826088 hsa-mir-9 Diabetes Mellitus In conclusion, this study first provides evidence that the circLRP6/miR5p/PRMT1 regulatory network can affect STZ-induced cell viability, oxidative stress, and insulin secretion in INS-l cells, which can further impact the progression of diabetes. +other 33826023 hsa-mir-585 Triple Negative Breast Neoplasms miR-585 may serve as a prognostic biomarker for patients with triple-negative breast cancer and it is expected to be a new method and strategy for the treatment of triple-negative breast cancer. +transcription factor target 33825830 hsa-mir-143 Colorectal Neoplasms BACKGROUND: There is accumulating evidence of aberrant expression of miR-143 and miR-145 and their target gene KRAS in colorectal cancer (CRC). RESULTS: Using publicly available expression profiling data, we found that miR-143/145 and KRAS expression were all reduced in rectal cancer tissue compared with adjacent non-neoplastic large intestinal mucosa. +genetics_GWAS 33825830 hsa-mir-145 Colorectal Neoplasms CONCLUSIONS: Our results indicate that miRNA-related polymorphisms in miR-143/145 and KRAS are likely to be deleterious and represent potential biomarkers for susceptibility to CRC and patients' survival. +lncRNA target 33825780 hsa-mir-183 Adenocarcinoma of Lung In conclusion, miR-183 may promote EMT and radioresistance in H1299 cells, and targeting the miRZEB1 signaling pathway may be a promising approach for lung cancer treatment. +circulation_biomarker_diagnosis_up 33825599 hsa-mir-590 Asthma 5p was lower in the serum of children with asthma than in control children. +other 33825069 hsa-mir-148a Mycobacterium Infections Our preliminary results supported the pivotal role of IFN in the local immune response related to PPD-B and highlighted the differential expression of miR-148a-3p, which downregulates the proinflammatory cytokines and the TLR4-mediated NF-B activation, providing an anti-inflammation modulator in responses to mycobacterial infection. +other 33825069 hsa-mir-122 Mycobacterium Infections 5p, was equally measured. +tissue_expression_ns 33824853 hsa-mir-143 Epstein-Barr Virus Infections This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. +tissue_expression_ns 33824853 hsa-mir-143 Herpes Simplex This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. +tissue_expression_ns 33824853 hsa-let-7b Herpes Simplex This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. +tissue_expression_ns 33824853 hsa-mir-145 Epstein-Barr Virus Infections This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. +tissue_expression_ns 33824853 hsa-mir-21 Herpes Simplex This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. +tissue_expression_ns 33824853 hsa-mir-125b Herpes Simplex This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. +tissue_expression_ns 33824853 hsa-mir-21 Epstein-Barr Virus Infections This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. +tissue_expression_ns 33824853 hsa-let-7b Epstein-Barr Virus Infections This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. +tissue_expression_ns 33824853 hsa-mir-125b Epstein-Barr Virus Infections This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. +tissue_expression_ns 33824853 hsa-mir-155 Epstein-Barr Virus Infections This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. +tissue_expression_ns 33824853 hsa-mir-145 Herpes Simplex This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. +tissue_expression_ns 33824853 hsa-mir-200c Herpes Simplex This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. +tissue_expression_ns 33824853 hsa-mir-200c Epstein-Barr Virus Infections This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. +tissue_expression_ns 33824853 hsa-mir-155 Herpes Simplex This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. +tissue_expression_ns 33824853 hsa-mir-182 Herpes Simplex This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. +tissue_expression_ns 33824853 hsa-mir-182 Epstein-Barr Virus Infections This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. +genetics_overexpression_promote 33824598 hsa-mir-375 Diabetes Mellitus, Type 2 PURPOSE: The pancreatic islet specific microRNA-375 (miR-375) is overexpressed in type 2 diabetes mellitus (T2DM) patients suppressing the glucose-induced insulin secretion. +circulation_biomarker_diagnosis_ns 33824597 hsa-mir-155 Pneumonia, Mycoplasma CONCLUSION: Serum miR-155 is poorly expressed in children with MPP, and it can regulate inflammatory disorders and immune responses. +lncRNA target 33824472 hsa-mir-204 Carcinoma, Hepatocellular Our data suggest that SNHG6 functions as a ceRNA that targets miR5p resulting in an increased E2F1 expression and enhanced G1-S phase transition, thereby promoting the tumorigenesis of HCC. +lncRNA target 33824420 hsa-mir-143 Carcinoma, Non-Small-Cell Lung 3p inhibitor rescued the inhibitory effect of sh-UCC on the proliferation of NSCLC cells. +circulation_biomarker_diagnosis_ns 33824379 hsa-mir-150 Cardiomyopathy, Dilated 3p) combined with clinical variables (left bundle branch block, left ventricle end-systolic dimension, lower systolic blood pressure and smoking habit) was obtained for idiopathic DCM with a severely reduced-EF. +circulation_biomarker_diagnosis_ns 33824379 hsa-mir-210 Cardiomyopathy, Dilated 3p) combined with clinical variables (left bundle branch block, left ventricle end-systolic dimension, lower systolic blood pressure and smoking habit) was obtained for idiopathic DCM with a severely reduced-EF. +circulation_biomarker_diagnosis_ns 33824379 hsa-mir-130b Cardiomyopathy, Dilated 3p) combined with clinical variables (left bundle branch block, left ventricle end-systolic dimension, lower systolic blood pressure and smoking habit) was obtained for idiopathic DCM with a severely reduced-EF. +lncRNA target 33824300 hsa-mir-130a Gastrointestinal Diseases Mechanistically, HOTAIR correlated negatively with miRNA-130a in GISTs. Our results suggested that HOTAIR targets the ATG2B inhibitor miR-130a to upregulate the level of cell autophagy so that promotes the imatinib resistance in GISTs. +lncRNA target 33824287 hsa-mir-20b Cardiomyopathies CircHIPK3 can accelerate cardiomyocyte autophagy and apoptosis during myocardial I/R injury through the miR-20b-5p/ATG7 axis. +lncRNA target 33824287 hsa-mir-20b Iron Metabolism Disorders CircHIPK3 can accelerate cardiomyocyte autophagy and apoptosis during myocardial I/R injury through the miR-20b-5p/ATG7 axis. +lncRNA target 33824287 hsa-mir-20b Myocardial Reperfusion Injury CircHIPK3 can accelerate cardiomyocyte autophagy and apoptosis during myocardial I/R injury through the miR-20b-5p/ATG7 axis. +genetics_knock down_promote 33824281 hsa-mir-145 Carcinoma, Hepatocellular 5p significantly attenuated the biological effects of hsa_circ_101555 knockdown in HCC cells. +transcription factor target 33824083 hsa-mir-34a Necrosis Puerarin facilitated osteogenesis of steroid-induced necrosis of rabbit femoral head and osteogenesis of steroid-induced osteocytes via miR-34a upregulation. +genetics_knock down_promote 33823894 hsa-mir-378a Breast Neoplasms RESULTS: Here, we provide clinical evidence that chemotherapy-elicited exosomal miR-378a-3p and miR-378d are closely related to the chemotherapy response and that exosomes produced by BC cells after stimulation with DOX or PTX deliver miR-378a-3p and miR-378d to neighboring cells to activate WNT and NOTCH stemness pathways and induce drug resistance by targeting Dickkopf 3 (DKK3) and NUMB. CONCLUSION: This study revealed a novel mechanism of acquired chemoresistance whereby chemotherapy activates the EZH2/STAT3 axis in BC cells, which then secrete chemotherapy-elicited exosomes enriched in miR-378a-3p and miR-378d. +lncRNA target 33823834 hsa-mir-1285 Osteosarcoma CONCLUSIONS: The results from the present study demonstrate the role of lncRNA SNHG16 in OS progression, which is SNHG16 might exert oncogenic role in osteosarcoma (OS) by acting as a ceRNA of miR3p, and it may become a novel target in OS therapy. +lncRNA target 33822671 hsa-mir-200b Diabetic Retinopathy In conclusion, SNHG4 may sponge miR-200b to inhibit cell apoptosis in DR by upregulating Oxr1. +other 33822652 hsa-mir-455 Atherosclerosis 5p may be used as a potential diagnostic biomarker for AS. +transcription factor target 33822516 hsa-mir-451 Leukemia, Myeloid, Acute MiR-451 might be considered a candidate target for treating pediatric AML. +genetics_knock down_promote 33822442 hsa-mir-646 Carcinoma, Endometrioid CONCLUSION: circ_0001610 knockdown represses EC progression through modulating the miR +genetics_knock down_suppress 33822440 hsa-mir-493 Melanoma Furthermore, knockdown of miR +other 33822434 hsa-mir-219 Leukodystrophy, Globoid Cell Here, we show that attenuated expression of microRNA (miR)-219, a critical regulator of OL differentiation and myelination, mediates cellular pathogenesis of KD OLs. Collectively, these results highlight the role of the reduced miR-219 expression in KD pathogenesis and suggest that miR-219 has therapeutic potential for treating KD OL pathologies. +lncRNA target 33821684 hsa-mir-744 Squamous Cell Carcinoma of Head and Neck Here, we aimed to disclose the role of MNX1-AS1 in LSCC progression, and explore whether MNX1-AS1 participates in LSCC progression via targeting miR +lncRNA target 33821668 hsa-mir-223 Cardiomegaly Suppression of microRNA-223 in cardiomyocytes inhibits calcineurin-mediated cardiac hypertrophy (n=6), revealing microRNA-223 as a novel prohypertrophic target of the calcineurin/NFAT and Erk1/2-ETS2 pathways. +genetics_overexpression_promote 33821473 hsa-mir-124 Colorectal Neoplasms Also, miR-124 exogenous overexpression could reduce colony and spheroid formation ability of CRC cells via downregulating CD44 mRNA expression. +exosome 33821219 hsa-mir-381 Breast Neoplasms Exosomal-mediated transfer of OIP5-AS1 enhanced cell chemoresistance to trastuzumab in breast cancer via up-regulating HMGB3 by sponging miR-381-3p. +lncRNA target 33820868 hsa-mir-186 Pancreatic Carcinoma OIP5-AS1, as a ceRNA, promotes the progression of pancreatic cancer by targeting miR +other 33820867 hsa-mir-454 Hip Dislocation, Congenital Experiments indicated that downregulated miRNA-454 caused FRZB upregulation in DDH joint. +genetics_overexpression_suppress 33820852 hsa-mir-617 Squamous Cell Carcinoma of Head and Neck More importantly, miR-617 mimic could block the effect of SERPINE1 overexpression on OSCC cell proliferation, viability, and apoptosis. +exosome 33820561 hsa-mir-26a Spinal Cord Injuries This research was designed to investigate the therapeutic effects of miR-26a-modified MSC-derived exosomes (Exos-26a) following SCI. +lncRNA target 33820555 hsa-mir-141 Breast Neoplasms CONCLUSIONS: EVs inhibit the regulation of KLF12 by miR +genetics_knock down_promote 33819917 hsa-mir-224 Carcinoma, Non-Small-Cell Lung Interestingly, both Sirt1 overexpression and HIF-1alpha inhibition repressed miR-224 levels and miR +genetics_overexpression_suppress 33819916 hsa-mir-142 Stomach Neoplasms We found that the overexpression of MSC-AS1 inhibited the expression of miR +circRNA target 33819864 hsa-mir-149 Pre-Eclampsia 5p/TFPI2 axis, revealing a new insight into the pathogenesis of PE and a potential therapeutic target for PE treatment. +genetics_knock down_promote 33819732 hsa-mir-383 psoriasis 1 Notably, miR-383 overexpression or LCN2 knockdown attenuated psoriasis-like symptoms, suppressed inflammatory response, reduced the expression of JAK3 and STAT3, ceased keratinocyte proliferation, and promoted the apoptosis. +other 33819576 hsa-mir-375 Osteoarthritis CONCLUSION: Circ_0001103 governed the miR-375/SIRT1 axis to ameliorate IL-1beta-induced chondrocyte injuries, implying that circ_0001103 was a promising biomarker in OA pathogenesis. +circulation_biomarker_diagnosis_ns 33819484 hsa-mir-193b Lymph Node Metastasis RESULTS: We used comprehensive expression profiling of a training cohort of LNM-positive and LMN-negative serum specimens to identify an optimized transcriptomic panel of 4 miRNAs (miR-181b, miR-193b, miR-195, and miR-411) and 5 mRNAs (AMT, forkhead box A1 [FOXA1], polymeric immunoglobulin receptor [PIGR], matrix metalloproteinase 1 [MMP1], and matrix metalloproteinase 9 [MMP9]), which robustly identified patients with LNM (area under the curve [AUC], 0.86; 95% confidence interval [CI], 0.72-0.94). +circulation_biomarker_diagnosis_ns 33819484 hsa-mir-193b Colorectal Neoplasms RESULTS: We used comprehensive expression profiling of a training cohort of LNM-positive and LMN-negative serum specimens to identify an optimized transcriptomic panel of 4 miRNAs (miR-181b, miR-193b, miR-195, and miR-411) and 5 mRNAs (AMT, forkhead box A1 [FOXA1], polymeric immunoglobulin receptor [PIGR], matrix metalloproteinase 1 [MMP1], and matrix metalloproteinase 9 [MMP9]), which robustly identified patients with LNM (area under the curve [AUC], 0.86; 95% confidence interval [CI], 0.72-0.94). +lncRNA target 33819467 hsa-mir-520b Sarcoma, Ewing Thus, we concluded that miR-520b suppressed EC inflammation and the cross-talk between monocytes and ECs by down-regulating NF-B p65-ICAM1/VCAM1 axis and might serve as a potential therapeutic target for EC dysfunction and atherosclerosis. +other 33819467 hsa-mir-520b Coronary Artery Disease However, the role of miR-520b in coronary artery disease still remains to be uncovered. +other 33819467 hsa-mir-520b Plaque, Atherosclerotic Previous reports indicated that the expression of miR-520b was repressed in human atherosclerotic plaque tissue compared with healthy vessels. In this study, we demonstrated that endothelial cells (ECs) in human atherosclerotic plaques expressed miR-520b and aimed to elucidate the impact of miR-520b on EC activation and inflammatory response. +transcription factor target 33819467 hsa-mir-520b Pituitary Diseases Thus, we concluded that miR-520b suppressed EC inflammation and the cross-talk between monocytes and ECs by down-regulating NF-B p65-ICAM1/VCAM1 axis and might serve as a potential therapeutic target for EC dysfunction and atherosclerosis. +other 33819360 hsa-mir-503 Cicatrix, Hypertrophic qRT-PCR was applied to examine the levels of MIR503HG and miR3p in HS tissues and human hypertrophic scar fibroblasts (hHSFs). +genetics_knock down_promote 33819360 hsa-mir-143 Cicatrix, Hypertrophic 3p and overexpression of Smad3, respectively, reversed these effects of knockdown of MIR503HG and overexpression of miR +lncRNA target 33819358 hsa-mir-103a Uterine Cervical Neoplasms Moreover, LINC00662 positively modulated PDK4 expression via competitively binding to miR-103a-3p in CC cells. Taken together, our study revealed a novel ceRNA pattern of LINC00662/miR-103a-3p/PDK4 with FOXA1 as a transcription factor of LINC00662 and PDK4 in CC cells. +genetics_overexpression_suppress 33819189 hsa-mir-10a Myocardial Infarction The results of in vitro and in vivo experimentation also suggested that overexpression of miR-10a-5p or silencing of MIAT and EGR2 reduced cardiomyocyte apoptosis and increased ATP content, thus alleviating the impairment of cardiac function following MI. +other 33818859 hsa-mir-134 Retinoblastoma Moreover, the rescue assays showed that KCNQ1OT1 promoted RB progression by regulating the miR-134/TRIM44 pathway. CONCLUSIONS: The present study indicates that a new KCNQ1OT1/miR-134/TRIM44 pathway regulates Rb progression. +lncRNA target 33818827 hsa-mir-377 Colorectal Adenocarcinoma Given the oncogenic activity of miR-377 and the oncosuppressive activity of T-cadherin in CRC, the regulatory circuit highlighted in this study may add new insights into molecular mechanisms driving colorectal carcinogenesis, and perspectively it could be exploited to identify novel biomarkers and therapeutic targets. +other 33818800 hsa-mir-101 Acquired Immunodeficiency Syndrome In the present study, the expression of miR-101, miR-122, miR-155, miR-192, miR-200c, miR-338, and miR-532 was determined by quantitative real-time polymerase chain reaction in liver biopsies of HCV (n = 19) and HCV/HIV-infected (n = 20) LT recipients, as well as in a control group (n = 18) of noninfected patients, transplanted for alcoholic cirrhosis. miR-101 (p = .03), miR-122 (p = .012), and miR-192 (p = .038) were significantly downregulated in HCV/HIV co-infected and HCV mono-infected recipients when compared with noninfected recipients, and such downregulation was more pronounced in co-infected ones. +other 33818800 hsa-mir-532 Acquired Immunodeficiency Syndrome In the present study, the expression of miR-101, miR-122, miR-155, miR-192, miR-200c, miR-338, and miR-532 was determined by quantitative real-time polymerase chain reaction in liver biopsies of HCV (n = 19) and HCV/HIV-infected (n = 20) LT recipients, as well as in a control group (n = 18) of noninfected patients, transplanted for alcoholic cirrhosis. +other 33818800 hsa-mir-532 Liver Diseases In the present study, the expression of miR-101, miR-122, miR-155, miR-192, miR-200c, miR-338, and miR-532 was determined by quantitative real-time polymerase chain reaction in liver biopsies of HCV (n = 19) and HCV/HIV-infected (n = 20) LT recipients, as well as in a control group (n = 18) of noninfected patients, transplanted for alcoholic cirrhosis. +other 33818800 hsa-mir-101 Liver Cirrhosis, Alcoholic In the present study, the expression of miR-101, miR-122, miR-155, miR-192, miR-200c, miR-338, and miR-532 was determined by quantitative real-time polymerase chain reaction in liver biopsies of HCV (n = 19) and HCV/HIV-infected (n = 20) LT recipients, as well as in a control group (n = 18) of noninfected patients, transplanted for alcoholic cirrhosis. +other 33818800 hsa-mir-122 Liver Cirrhosis, Alcoholic In the present study, the expression of miR-101, miR-122, miR-155, miR-192, miR-200c, miR-338, and miR-532 was determined by quantitative real-time polymerase chain reaction in liver biopsies of HCV (n = 19) and HCV/HIV-infected (n = 20) LT recipients, as well as in a control group (n = 18) of noninfected patients, transplanted for alcoholic cirrhosis. +other 33818800 hsa-mir-122 Acquired Immunodeficiency Syndrome In the present study, the expression of miR-101, miR-122, miR-155, miR-192, miR-200c, miR-338, and miR-532 was determined by quantitative real-time polymerase chain reaction in liver biopsies of HCV (n = 19) and HCV/HIV-infected (n = 20) LT recipients, as well as in a control group (n = 18) of noninfected patients, transplanted for alcoholic cirrhosis. miR-101 (p = .03), miR-122 (p = .012), and miR-192 (p = .038) were significantly downregulated in HCV/HIV co-infected and HCV mono-infected recipients when compared with noninfected recipients, and such downregulation was more pronounced in co-infected ones. +other 33818800 hsa-mir-122 Liver Diseases In the present study, the expression of miR-101, miR-122, miR-155, miR-192, miR-200c, miR-338, and miR-532 was determined by quantitative real-time polymerase chain reaction in liver biopsies of HCV (n = 19) and HCV/HIV-infected (n = 20) LT recipients, as well as in a control group (n = 18) of noninfected patients, transplanted for alcoholic cirrhosis. +other 33818800 hsa-mir-200c Liver Diseases In the present study, the expression of miR-101, miR-122, miR-155, miR-192, miR-200c, miR-338, and miR-532 was determined by quantitative real-time polymerase chain reaction in liver biopsies of HCV (n = 19) and HCV/HIV-infected (n = 20) LT recipients, as well as in a control group (n = 18) of noninfected patients, transplanted for alcoholic cirrhosis. +other 33818800 hsa-mir-192 Liver Diseases In the present study, the expression of miR-101, miR-122, miR-155, miR-192, miR-200c, miR-338, and miR-532 was determined by quantitative real-time polymerase chain reaction in liver biopsies of HCV (n = 19) and HCV/HIV-infected (n = 20) LT recipients, as well as in a control group (n = 18) of noninfected patients, transplanted for alcoholic cirrhosis. +other 33818800 hsa-mir-155 Liver Diseases In the present study, the expression of miR-101, miR-122, miR-155, miR-192, miR-200c, miR-338, and miR-532 was determined by quantitative real-time polymerase chain reaction in liver biopsies of HCV (n = 19) and HCV/HIV-infected (n = 20) LT recipients, as well as in a control group (n = 18) of noninfected patients, transplanted for alcoholic cirrhosis. +other 33818800 hsa-mir-155 Acquired Immunodeficiency Syndrome In the present study, the expression of miR-101, miR-122, miR-155, miR-192, miR-200c, miR-338, and miR-532 was determined by quantitative real-time polymerase chain reaction in liver biopsies of HCV (n = 19) and HCV/HIV-infected (n = 20) LT recipients, as well as in a control group (n = 18) of noninfected patients, transplanted for alcoholic cirrhosis. +other 33818800 hsa-mir-155 Liver Cirrhosis, Alcoholic In the present study, the expression of miR-101, miR-122, miR-155, miR-192, miR-200c, miR-338, and miR-532 was determined by quantitative real-time polymerase chain reaction in liver biopsies of HCV (n = 19) and HCV/HIV-infected (n = 20) LT recipients, as well as in a control group (n = 18) of noninfected patients, transplanted for alcoholic cirrhosis. +other 33818800 hsa-mir-192 Acquired Immunodeficiency Syndrome In the present study, the expression of miR-101, miR-122, miR-155, miR-192, miR-200c, miR-338, and miR-532 was determined by quantitative real-time polymerase chain reaction in liver biopsies of HCV (n = 19) and HCV/HIV-infected (n = 20) LT recipients, as well as in a control group (n = 18) of noninfected patients, transplanted for alcoholic cirrhosis. miR-101 (p = .03), miR-122 (p = .012), and miR-192 (p = .038) were significantly downregulated in HCV/HIV co-infected and HCV mono-infected recipients when compared with noninfected recipients, and such downregulation was more pronounced in co-infected ones. +other 33818800 hsa-mir-200c Liver Cirrhosis, Alcoholic In the present study, the expression of miR-101, miR-122, miR-155, miR-192, miR-200c, miR-338, and miR-532 was determined by quantitative real-time polymerase chain reaction in liver biopsies of HCV (n = 19) and HCV/HIV-infected (n = 20) LT recipients, as well as in a control group (n = 18) of noninfected patients, transplanted for alcoholic cirrhosis. +other 33818800 hsa-mir-200c Acquired Immunodeficiency Syndrome In the present study, the expression of miR-101, miR-122, miR-155, miR-192, miR-200c, miR-338, and miR-532 was determined by quantitative real-time polymerase chain reaction in liver biopsies of HCV (n = 19) and HCV/HIV-infected (n = 20) LT recipients, as well as in a control group (n = 18) of noninfected patients, transplanted for alcoholic cirrhosis. +other 33818800 hsa-mir-532 Liver Cirrhosis, Alcoholic In the present study, the expression of miR-101, miR-122, miR-155, miR-192, miR-200c, miR-338, and miR-532 was determined by quantitative real-time polymerase chain reaction in liver biopsies of HCV (n = 19) and HCV/HIV-infected (n = 20) LT recipients, as well as in a control group (n = 18) of noninfected patients, transplanted for alcoholic cirrhosis. +other 33818800 hsa-mir-101 Liver Diseases In the present study, the expression of miR-101, miR-122, miR-155, miR-192, miR-200c, miR-338, and miR-532 was determined by quantitative real-time polymerase chain reaction in liver biopsies of HCV (n = 19) and HCV/HIV-infected (n = 20) LT recipients, as well as in a control group (n = 18) of noninfected patients, transplanted for alcoholic cirrhosis. +other 33818800 hsa-mir-192 Liver Cirrhosis, Alcoholic In the present study, the expression of miR-101, miR-122, miR-155, miR-192, miR-200c, miR-338, and miR-532 was determined by quantitative real-time polymerase chain reaction in liver biopsies of HCV (n = 19) and HCV/HIV-infected (n = 20) LT recipients, as well as in a control group (n = 18) of noninfected patients, transplanted for alcoholic cirrhosis. +genetics_overexpression_promote 33818788 hsa-mir-409 Uterine Cervical Neoplasms 3p overexpression impeded CC cell growth and motility, which was attenuated by CDK8. +other 33818699 hsa-mir-151a Ischemic Stroke CONCLUSIONS: miRNAs were involved in IS pathogenesis, and hsa-miR5p, hsa-miR-151a-3p and hsa-miR-29c-5p as the three highest |log2FoldChange| regulation in this study, which may be the biomarkers of IS and need further study. +lncRNA target 33818550 hsa-mir-214 Atherosclerosis In conclusion, circ_GRN promoted the proliferation, migration, and inflammation of HVSMCs through miR3p/FOXO1 axis in ox-LDL-induced AS model in vitro, suggesting the potential involvement in an AS process, which provided a potential candidate for future clinic intervention in AS. +genetics_knock down_promote 33818283 hsa-mir-185 Ovarian Neoplasms OC cell lines SKOV3 and HO-8910 were treated with DEX, after which OC development and the miR-185, SOX9, and Wnt/beta-catenin pathway were measured. +genetics_overexpression_suppress 33818282 hsa-mir-1269b Stomach Neoplasms Methyltransferase-like 3 (METTL3) was identified as the direct target of miR-1269b in GC cells, and its overexpression reversed the inhibitory effect of transfection of miR-1269b mimics on GC cell viability, migration and invasion. +lncRNA target 33818278 hsa-mir-340 Optic atrophy 1 and deafness In short, the above findings revealed that inhibition of miR5p facilitated osteogenic differentiation through regulating RUNX2 in MC3TC-E1 cells, which provided targeted therapeutic strategies for the treatment of DOP. +lncRNA target 33818249 hsa-mir-141 Atherosclerosis 3p mimic decreased the damage in an AS model by targeting Wnt5a, thereby presenting a novel potential therapeutic target for treating AS. +other 33818020 hsa-mir-130a Breast Neoplasms CONCLUSION: MiR-130a increases constantly and predicts high cardiotoxicity risk during EC-D+T adjuvant chemotherapy in HER2(+) breast cancer patients. +other 33818020 hsa-mir-130a Cardiotoxicity CONCLUSION: MiR-130a increases constantly and predicts high cardiotoxicity risk during EC-D+T adjuvant chemotherapy in HER2(+) breast cancer patients. +other 33817353 hsa-mir-15b Neonatal Sepsis The aim of this research is to assess the diagnostic and prognostic biomarkers of miRNA 15b and miRNA 378a for neonatal sepsis. CONCLUSION: Both MiRNA 15b and 378a are promising biomarker for neonatal sepsis. +target gene 33817324 hsa-mir-377 Diabetes, Gestational miR-377 inhibition enhances the survival of trophoblast cells via upregulation of FNDC5 in gestational diabetes mellitus. +genetics_overexpression_promote 33817318 hsa-mir-299 Stomach Neoplasms Besides, overexpression of miR +genetics_overexpression_suppress 33817317 hsa-mir-146b Pancreatitis CONCLUSIONS: The current work had led to the identification of miR-146b-3p overexpression that protected against cerulein-induced injury in AR42J cells at least in part by targeting Anxa2, revealing a promising target for AP diagnosis and treatment. +genetics_knock down_suppress 33817315 hsa-mir-497 Hypertrophy miR-497 overexpression mediated the protective role of TUG1 knockdown in Ang II-induced cardiomyocyte hypertrophy. +genetics_knock down_suppress 33817315 hsa-mir-497 Cardiomegaly miR-497 overexpression mediated the protective role of TUG1 knockdown in Ang II-induced cardiomyocyte hypertrophy. +target gene 33817311 hsa-mir-338 Neuroblastoma miR-338-3p inhibits cell growth, invasion, and EMT process in neuroblastoma through targeting MMP-2. +genetics_knock down_promote 33817300 hsa-mir-1287 Carcinoma, Hepatocellular MiR-1287 knockdown reversed the effects caused by circ_0091579 interference on the functions of HCC cells. +genetics_knock down_promote 33817293 hsa-mir-503 Uterine Cervical Neoplasms PVT1 knockdown exerted tumor suppressor role in CC progression via the miR-503/ARL2 axis, at least in part. +other 33817287 hsa-mir-212 Leukemia, Myeloid, Acute 5p/CCNT2 axis had an implication in the anti-leukemic effect of decitabine in AML. +lncRNA target 33817286 hsa-mir-150 familial febrile seizures 1 CONCLUSION: FTX relieves H(2)O(2)-induced cardiomyocyte injury by increasing KLF13 expression via depletion of miR-150, thus providing a novel therapeutic target for the alleviation of I/R injury. +lncRNA target 33817286 hsa-mir-150 Reperfusion Injury CONCLUSION: FTX relieves H(2)O(2)-induced cardiomyocyte injury by increasing KLF13 expression via depletion of miR-150, thus providing a novel therapeutic target for the alleviation of I/R injury. +lncRNA target 33817286 hsa-mir-150 Iron Metabolism Disorders CONCLUSION: FTX relieves H(2)O(2)-induced cardiomyocyte injury by increasing KLF13 expression via depletion of miR-150, thus providing a novel therapeutic target for the alleviation of I/R injury. +genetics_knock down_suppress 33817285 hsa-mir-424 Glioma Analogously, knockdown of miR +genetics_overexpression_promote 33817278 hsa-mir-39 Pancreatitis Overexpression of miR +target gene 33817274 hsa-mir-381 Osteosarcoma LncRNA SNHG15 contributes to doxorubicin resistance of osteosarcoma cells through targeting the miR-381-3p/GFRA1 axis. +other 33817271 hsa-mir-218 Osteosarcoma CircSAMD4A contributes to cell doxorubicin resistance in osteosarcoma by regulating the miR-218-5p/KLF8 axis +circRNA target 33817265 hsa-mir-1 Melanoma Circ_0084043 promoted cell proliferation and glycolysis, and blocked apoptosis through the circ_0084043-miRKLF3 regulatory axis in melanoma. +other 33817257 hsa-mir-381 Lung Neoplasms CircHIPK3/miR-381-3p axis modulates proliferation, migration, and glycolysis of lung cancer cells by regulating the AKT/mTOR signaling pathway. +genetics_knock down_promote 33817255 hsa-mir-124 Parkinson Disease NEAT1 knockdown increased cell viability and suppressed apoptosis in PD via regulating the miR-124/KLF4 axis, providing a promising avenue for the treatment of PD. +lncRNA target 33817254 hsa-mir-384 Glioma The expression of SNHG3 and HDGF was upregulated, whereas miR-384 was downregulated in glioma tissues, compared with the normal tissues. LncRNA SNHG3 promotes cell proliferation, migration, and invasion in glioma by enhancing HDGF expression via miR-384 sponging, representing the promising targets for the development of novel therapeutic strategies. +circulation_biomarker_diagnosis_ns 33817253 hsa-mir-132 Parkinson Disease 3p and miR-146a-5p expressions were significantly decreased in the serum samples of patients with PD compared to those in the healthy volunteers. +circulation_biomarker_diagnosis_ns 33817253 hsa-mir-146 Parkinson Disease 3p and miR-146a-5p expressions were significantly decreased in the serum samples of patients with PD compared to those in the healthy volunteers. +circulation_biomarker_diagnosis_ns 33817253 hsa-mir-146a Parkinson Disease 3p and miR-146a-5p expressions were significantly decreased in the serum samples of patients with PD compared to those in the healthy volunteers. +genetics_overexpression_suppress 33817252 hsa-mir-4328 Keloid In addition, BCL2 was confirmed to be a target of miR-4328, and the rescue experiment indicated that the inhibitory action of miR-4328 on keloid fibroblast progression was reversed by BCL2 overexpression. +lncRNA target 33817244 hsa-mir-204 Thyroid Cancer, Papillary 5p/HMGB1 axis, providing a novel therapeutic target for PTC patients. +circulation_biomarker_prognosis_ns 33817242 hsa-mir-150 Critical Illness Circulating miR5p has been identified as a prognostic marker in patients with critical illness and sepsis. +circulation_biomarker_prognosis_ns 33817242 hsa-mir-150 Sepsis Circulating miR +genetics_knock down_promote 33817241 hsa-mir-216a Glioma LINC00461 was upregulated, and miR-216a was downregulated in glioma tissues and cells, and LINC00461 upregulation was correlated with large tumor size, higher WHO grade and recurrence, and poor overall survival. In conclusion, LINC00461 knockdown inhibits glioma cell proliferation, migration, invasion, and TMZ resistance through miR-216a/AQP4 axis, suggesting LINC00461 as an oncogene in glioma progression. +lncRNA target 33817237 hsa-mir-485 Carcinoma, Squamous Cell, Cutaneous 5p inhibition reversed the impacts of lnc-PICSAR silencing on DDP resistance and cell progression in DDP-resistant CSCC cells. +target gene 33817236 hsa-mir-185 Osteosarcoma Circ_001569 regulates FLOT2 expression to promote the proliferation, migration, invasion and EMT of osteosarcoma cells through sponging miR-185-5p +lncRNA target 33817232 hsa-mir-204 Retinoblastoma In all, LINC00202 promoted RB cell proliferation, glycolysis, and suppressed apoptosis by regulating the miR +target gene 33817231 hsa-mir-346 Osteosarcoma LncRNA SNHG15 regulates osteosarcoma progression in vitro and in vivo via sponging miR-346 and regulating TRAF4 expression. +target gene 33817227 hsa-mir-223 Carcinoma, Non-Small-Cell Lung MiR-223-3p regulates cell viability, migration, invasion, and apoptosis of non-small cell lung cancer cells by targeting RHOB. +genetics_knock down_promote 33817216 hsa-mir-489 Glioblastoma The protein levels of p-AKT and p-PI3K were notably reduced in GBM cells by overexpression of miR +other 33817175 hsa-mir-182 Brain Ischemia The experiment of cerebral ischemic oxidative stress model rats showed that the survival rate, apoptosis rate, malondialdehyde and superoxide dismutase levels in miR-182 group were better than model control group. +circulation_biomarker_diagnosis_up 33817137 hsa-mir-122 Carcinoma, Hepatocellular Overall, this study revealed that serum expression of GPC3 and miR-122 may be useful biomarkers to combine with serum AFP expression for the diagnosis of HCV related early-stage HCC. +other 33817119 hsa-mir-539 Pancreatic Carcinoma Down-regulation of miR-539 may be a potentially unfavorable prognostic factor for patients with pancreatic cancer, and further studies are needed to confirm our conclusion in the future. +lncRNA target 33817087 hsa-mir-145 Gallbladder Neoplasms CONCLUSION: Thus, we speculate that miRNA-145 facilitates inhibition of GBC-SD cell growth and invasion while inducing apoptosis by targeting DFF45; however, miRNA-145 does not directly affect the GBC-SD cell cycle. +lncRNA target 33816782 hsa-let-7e Carcinoma, Non-Small-Cell Lung Taken together, the key findings of the current study demonstrate a novel lncRNA SNHG4/let-7e/KDM3A/p21 axis in NSCLC, highlighting a promising therapeutic target for NSCLC. +genetics_knock down_promote 33816780 hsa-mir-149 Colorectal Neoplasms These new findings indicate that DLGAP1-AS1 knockdown inhibited the progression of CRC and enhanced the 5-FU sensitivity of CRC cells through miR +genetics_GWAS 33816633 hsa-mir-124 Uterine Cervical Neoplasms The miR-124 rs531564 polymorphism was associated with a statistically increased risk of cervical cancer in a homozygote model (CC vs. +lncRNA target 33816607 hsa-mir-497 Carcinoma, Hepatocellular 5p may be a specific therapeutic target for the treatment of HCC. +other 33816578 hsa-mir-3679 Arrhythmogenic Right Ventricular Dysplasia 5p) were found to be differentially expressed between patients with ARVC and patients with post-infarction VT. +other 33816578 hsa-mir-3679 Myocardial Ischemia 5p) were found to be differentially expressed between patients with ARVC and patients with post-infarction VT. +other 33816578 hsa-mir-122 Arrhythmogenic Right Ventricular Dysplasia 5p) were found to be differentially expressed between patients with ARVC and patients with post-infarction VT. +other 33816578 hsa-mir-21 Arrhythmogenic Right Ventricular Dysplasia 5p) were found to be differentially expressed between patients with ARVC and patients with post-infarction VT. +other 33816578 hsa-mir-206 Arrhythmogenic Right Ventricular Dysplasia 5p) were found to be differentially expressed between patients with ARVC and patients with post-infarction VT. +other 33816578 hsa-mir-122 Myocardial Ischemia 5p) were found to be differentially expressed between patients with ARVC and patients with post-infarction VT. +other 33816578 hsa-mir-1 Myocardial Ischemia 5p) were found to be differentially expressed between patients with ARVC and patients with post-infarction VT. +other 33816578 hsa-mir-206 Myocardial Ischemia 5p) were found to be differentially expressed between patients with ARVC and patients with post-infarction VT. +other 33816578 hsa-mir-1 Arrhythmogenic Right Ventricular Dysplasia 5p) were found to be differentially expressed between patients with ARVC and patients with post-infarction VT. +other 33816578 hsa-mir-21 Myocardial Ischemia 5p) were found to be differentially expressed between patients with ARVC and patients with post-infarction VT. +lncRNA target 33816571 hsa-mir-132 Heart Failure The up-regulation of miR-132/212 in heart failure impairs cardiac contractile function by targeting SERCA2a, suggesting that pharmaceutical inhibition of miR-132/212 might be a promising therapeutic approach to promote cardiac function in heart failure patients. +target gene 33816494 hsa-mir-26a Osteosarcoma miR-26a Reverses Multidrug Resistance in Osteosarcoma by Targeting MCL1. +genetics_overexpression_promote 33816484 hsa-mir-1 Intervertebral Disc Degeneration In conclusion, overexpression of miR +target gene 33816469 hsa-mir-184 Stomach Neoplasms Downregulated miR-184 expression in SNHG11 silenced GC cells showed that miR-184 inhibition reversed the effect of LncRNA SNHG11 silencing on the growth, proliferation, apoptosis, and migration of GC cells. +genetics_knock down_suppress 33816305 hsa-mir-335 Lymphoma, Large B-Cell, Diffuse 5p inhibitor partially canceled the inhibitory effects of the knockdown of SNHG8 on DLBCL cell proliferation and colony formation and the stimulating effects of the knockdown of SNHG8 on cell apoptosis. +target gene 33816296 hsa-mir-650 Melanoma LncRNA POU3F3 Contributes to Dacarbazine Resistance of Human Melanoma Through the MiR-650/MGMT Axis. +other 33816278 hsa-mir-130b Stomach Neoplasms CMPK1 Regulated by miR-130b Attenuates Response to 5-FU Treatment in Gastric Cancer. +circulation_biomarker_diagnosis_up 33816263 hsa-mir-940 Prostatic Neoplasms Here, we investigate circulating miR-940, a miRNA known to play a role in prostate cancer progression, in both cell culture supernatants as well as patient serum and urine samples to determine the utility of miR-940 as a new molecular marker for prostate cancer detection. +genetics_overexpression_promote 33816255 hsa-mir-15a Carcinoma, Hepatocellular Overexpressed Tumor Suppressor Exosomal miR-15a-5p in Cancer Cells Inhibits PD1 Expression in CD8+T Cells and Suppresses the Hepatocellular Carcinoma Progression. +lncRNA target 33816238 hsa-mir-182 Squamous Cell Carcinoma of Head and Neck CONCLUSION: Exo-LBX1-AS1 secreted from RBPJ-OE Mphi inhibits tumor progression through the LBX1-AS1/miR5p/FOXO3 pathway, and LBX1-AS1 is probably a diagnostic biomarker and potential target for OSCC therapy. +lncRNA target 33816233 hsa-mir-133b Glioma Collectively, HOTAIRM1/miR-133b-3p/TGFbeta axis was involved in modulating t-FBs malignancy in TME remodeled by GSCs, which had the potential to serve as a target against gliomas. +other 33816075 hsa-mir-124 Carcinoma, Renal Cell Our results showed that miR-124 expression levels are associated with RCC. MicroRNA-124 may be assessed as a biomarker in prognosis and the restoration of miR-124 expression might be effective in the treatment of RCC. +other 33815939 hsa-mir-26a Colitis However, the specific role of miR-26a in colonic inflammation and colitis-associated carcinogenesis is still elusive. +other 33815939 hsa-mir-26a Colitis-Associated Neoplasms However, the specific role of miR-26a in colonic inflammation and colitis-associated carcinogenesis is still elusive. +other 33815676 hsa-mir-1298 Precancerous Conditions RESULTS: 2-AAF administration significantly increased the percent area of the precancerous foci and cell proliferation along with a significant decrease in RAB11A, BAX, and p53 mRNA, and the increase in Cyclin E mRNA was associated with a marked decrease in lncRNA RP11-513I15.6 expression with a significant increase in both miR-1262 and miR-1298. +other 33815676 hsa-mir-1262 Precancerous Conditions RESULTS: 2-AAF administration significantly increased the percent area of the precancerous foci and cell proliferation along with a significant decrease in RAB11A, BAX, and p53 mRNA, and the increase in Cyclin E mRNA was associated with a marked decrease in lncRNA RP11-513I15.6 expression with a significant increase in both miR-1262 and miR-1298. +genetics_GWAS 33815256 hsa-mir-204 Congenital central hypoventilation syndrome Overall, these results suggest that, at least in the Italian population, the SNP c(*)161G>A (rs114290493) does contribute, presumably in association with others mutations or polymorphisms, to confer susceptibility to sudden unexplained perinatal life-threatening or fatal disorders by increasing the effect of miR-204 in inducing PHOX2B expression down-regulation. +lncRNA target 33815136 hsa-mir-150 Stroke In this work, we demonstrate that microRNA-150 (miR-150) and its predicted target MYB form a negative feedback loop to control the level of post-stroke VEGF expression. +lncRNA target 33815116 hsa-mir-21 Diabetes Mellitus, Type 2 Conclusion: The results of our study indicate that vild prevents DCM by restoring autophagy through the miR-21/SPRY1/ERK/mTOR pathway. Therefore, miR-21 is a target in the development of DCM, and vild demonstrates significant potential for clinical application in prevention of DCM. +lncRNA target 33815116 hsa-mir-21 Cardiomyopathies Conclusion: The results of our study indicate that vild prevents DCM by restoring autophagy through the miR-21/SPRY1/ERK/mTOR pathway. Therefore, miR-21 is a target in the development of DCM, and vild demonstrates significant potential for clinical application in prevention of DCM. +lncRNA target 33814920 hsa-mir-138 Cognition Disorders 5p is downregulated in microarray data of cognitive impairment animals and could directly target the 3'-UTR of NLRP3. +circulation_biomarker_diagnosis_up 33813728 hsa-mir-21 Ovarian Neoplasms 5p was upregulated in ovarian cancer tissues, plasma exosomes of ovarian cancer patients, and exosomes from ovarian cancer cells. +other 33813720 hsa-mir-216a Pancreatic Carcinoma The hsa-miR-210 had upregulation, whereas hsa-miR-375, hsa-miR-216a, hsa-miR-217, hsa-miR-216b and hsa-miR-634 had downregulation in pancreatic cancer (PC). +other 33813720 hsa-mir-375 Pancreatic Carcinoma The hsa-miR-210 had upregulation, whereas hsa-miR-375, hsa-miR-216a, hsa-miR-217, hsa-miR-216b and hsa-miR-634 had downregulation in pancreatic cancer (PC). +other 33813720 hsa-mir-217 Pancreatic Carcinoma The hsa-miR-210 had upregulation, whereas hsa-miR-375, hsa-miR-216a, hsa-miR-217, hsa-miR-216b and hsa-miR-634 had downregulation in pancreatic cancer (PC). +other 33813720 hsa-mir-210 Pancreatic Carcinoma The hsa-miR-210 had upregulation, whereas hsa-miR-375, hsa-miR-216a, hsa-miR-217, hsa-miR-216b and hsa-miR-634 had downregulation in pancreatic cancer (PC). +other 33813720 hsa-mir-216b Pancreatic Carcinoma The hsa-miR-210 had upregulation, whereas hsa-miR-375, hsa-miR-216a, hsa-miR-217, hsa-miR-216b and hsa-miR-634 had downregulation in pancreatic cancer (PC). +other 33813720 hsa-mir-634 Pancreatic Carcinoma The hsa-miR-210 had upregulation, whereas hsa-miR-375, hsa-miR-216a, hsa-miR-217, hsa-miR-216b and hsa-miR-634 had downregulation in pancreatic cancer (PC). +circulation_biomarker_diagnosis_ns 33813678 hsa-mir-193a Fractures, Bone The serum expression level of miR-193a-3p showed no significant change in fracture patients 7 days after fixation treatment, but over time, there was a significant decrease in the expression at 14 days and 21 days after treatment (P < 0.01). +other 33813342 hsa-mir-326 Pre-Eclampsia Furthermore, analysis such as flow cytometry, real-time PCR, western blotting, and ELISA were performed to assess determinants related to PE manifestation, including sFlt-1, sEng, STAT-3, RORgammat, SMAD-7, Foxp3, IL-17, IL-22, Ets-1, and miRNA-326. RESULTS: Our results showed that the miRNA-326 expression level increased in CD4(+) Cells and Th17 in PE patients which downregulated Ets-1 expression that acts as a negative control for Th17 development. +lncRNA target 33812758 hsa-mir-320e Hypersensitivity Decreased miRNA-320e correlates with allergy in children with otitis media with effusion. CONCLUSIONS MiRNA expression differs between children with and without allergy in the course of OME, but further studies are needed to explain the exact role of miR-320e and its target genes in OME pathology in allergic patients. +circulation_biomarker_prognosis_ns 33812413 hsa-mir-370 Leukemia, Myeloid, Acute CONCLUSION: The expression of miR-370 and miR-203 is decreased in the serum of patients with AML and may be a new markers for the diagnosis and prognosis of AML. +circulation_biomarker_prognosis_ns 33812413 hsa-mir-203 Leukemia, Myeloid, Acute CONCLUSION: The expression of miR-370 and miR-203 is decreased in the serum of patients with AML and may be a new markers for the diagnosis and prognosis of AML. +lncRNA target 33812412 hsa-mir-96 Leukemia, Myeloid, Acute CONCLUSION: MiR-96 has significant negative effect on invasion and apoptosis of AML cells by targeting regulation MYB, and it might be a potential novel strategy for pediatric AML treatment. +circulation_biomarker_prognosis_up 33812045 hsa-mir-20b Carcinoma, Hepatocellular INTRODUCTION AND OBJECTIVES: This study aimed to explore the functional mechanism of the miRNA-20b-5p/cytoplasmic polyadenylation element binding protein 3 (miR-20b-5p/CPEB3) axis in hepatocellular carcinoma (HCC) so as to provide a new idea for targeted therapy of HCC. +other 33812011 hsa-mir-208 Cardiomegaly It suggested that the up-regulation of miR-208b/beta-MHC and GATA4 and the conversion from alpha-MHC to beta-MHC may be the important causes of cardiac hypertrophy in rats incurred by PM(2.5). +other 33812011 hsa-mir-208 Heart Injuries It suggested that the up-regulation of miR-208b/beta-MHC and GATA4 and the conversion from alpha-MHC to beta-MHC may be the important causes of cardiac hypertrophy in rats incurred by PM(2.5). +other 33812011 hsa-mir-208b Heart Injuries It suggested that the up-regulation of miR-208b/beta-MHC and GATA4 and the conversion from alpha-MHC to beta-MHC may be the important causes of cardiac hypertrophy in rats incurred by PM(2.5). +other 33812011 hsa-mir-208b Cardiomegaly It suggested that the up-regulation of miR-208b/beta-MHC and GATA4 and the conversion from alpha-MHC to beta-MHC may be the important causes of cardiac hypertrophy in rats incurred by PM(2.5). +transcription factor target 33811860 hsa-mir-21 Osteoporosis 5p is a new therapeutic target for osteoporosis. +lncRNA target 33811842 hsa-mir-770 Glioblastoma CONCLUSION: CircABCC3 regulated glioblastoma development via miR +target gene 33811578 hsa-mir-19 Lung Neoplasms Interleukin-17A mediates tobacco smoke-induced lung cancer epithelial-mesenchymal transition through transcriptional regulation of ΔNp63α on miR-19. +genetics_overexpression_promote 33811437 hsa-mir-365 Carcinoma, Pancreatic Ductal We further demonstrated that overexpression of BTG2 could delay the progression of PDAC in vitro, whereas by impairing BTG2-mediated anti-tumour effect, M2-EV-miR-365 promoted PDAC progression. +other 33811432 hsa-mir-1297 Diabetic Nephropathies BACKGROUND: In this study, we aimed to explore whether COL1A2 and miR-1297 participated in the progression of diabetic nephropathy (DN) in vitro and classified the underlying mechanisms. +lncRNA target 33811432 hsa-mir-1297 Norrie disease CONCLUSION: This study sheds a light on the role miR-1297/COL1A2 in DN progression and provides a novel promising therapy strategy for suppressing DN progression. +genetics_overexpression_promote 33811301 hsa-mir-199a aortic atherosclerosis Overexpression of miR-199a-3p exists suppressive effects on VSMC proliferation and migration, indicating that miR-199a-3p may be a potential therapeutic target for AS treatment. +circulation_biomarker_diagnosis_ns 33810936 hsa-mir-199 Movement Disorders RESULTS: Only the serum level of miR-199 was significantly associated with LS after adjustment for age, BMI, sex, and all comorbidities. +other 33810186 hsa-mir-19b Rectal Neoplasms Finally, multivariate analyses determined that miR-19b independently predicts both patient outcome and response to preoperative CRT, highlighting its potential clinical usefulness in the management of LARC patients. +other 33809988 hsa-mir-221 Pancreatic Intraductal Neoplasms In IPMN associated with invasive carcinoma (INV), miR-10a-5p and miR3p were upregulated and miR-148a-3p was downregulated when compared with noninvasive IPMN. +other 33809988 hsa-mir-148a Pancreatic Intraductal Neoplasms In IPMN associated with invasive carcinoma (INV), miR-10a-5p and miR3p were upregulated and miR-148a-3p was downregulated when compared with noninvasive IPMN. +other 33809988 hsa-mir-10a Pancreatic Intraductal Neoplasms MiR-10a-5p is a promising additional biomarker for invasive IPMN. +other 33808771 hsa-mir-29b Melanoma Expression analyses in melanocytes, melanoma cells, nevi, and primary melanoma revealed that pri-miR-29b2~c levels decrease during melanoma progression. Our findings suggest that attenuation of miR-29b2~c expression promotes melanoma development, at least in part, by derepressing MAFG and MYBL2. +other 33808771 hsa-mir-29 Melanoma Expression analyses in melanocytes, melanoma cells, nevi, and primary melanoma revealed that pri-miR-29b2~c levels decrease during melanoma progression. +other 33808213 hsa-mir-106b Heart Failure "CONCLUSIONS: Results suggest a role of Nourin-associated miR-137 and miR-106b-5p in the pathogenesis of HF and that CCrP treatment prevented ischemic injury in ""non-HF rats"" and significantly reduced Nourin gene expression levels in a dose-response manner." +other 33808213 hsa-mir-137 Heart Failure "CONCLUSIONS: Results suggest a role of Nourin-associated miR-137 and miR-106b-5p in the pathogenesis of HF and that CCrP treatment prevented ischemic injury in ""non-HF rats"" and significantly reduced Nourin gene expression levels in a dose-response manner." +other 33808110 hsa-mir-338 Status Asthmaticus MiRNA3p could be used as a biomarker of early response to reslizumab and mepolizumab in severe eosinophilic asthmatic patients. +other 33807023 hsa-mir-28 Penile Neoplasms The lower expression levels for miR-137 and miR3p in metastatic usual PSCC were validated by qRT-PCR. +other 33807023 hsa-mir-137 Penile Neoplasms The lower expression levels for miR-137 and miR3p in metastatic usual PSCC were validated by qRT-PCR. +other 33806966 hsa-mir-223 Colitis, Ulcerative 5p) identified those patients with PSC. +other 33806966 hsa-mir-142 Colitis, Ulcerative 5p) identified those patients with PSC. +other 33806966 hsa-mir-146a Colitis, Ulcerative 5p) identified those patients with PSC. +other 33806966 hsa-mir-375 Colitis, Ulcerative 5p) was associated with early relapse of the disease. +other 33806966 hsa-mir-194 Colitis, Ulcerative 5p) identified those patients with PSC. +other 33806966 hsa-mir-192 Colitis, Ulcerative 5p) identified those patients with PSC. +other 33806966 hsa-mir-21 Colitis, Ulcerative 5p) was associated with early relapse of the disease. +other 33806966 hsa-let-7i Colitis, Ulcerative 5p) identified those patients with PSC. +other 33806619 hsa-mir-21 Multiple Myeloma MicroRNAs miR-193b-3p and miR5p emerged among the top deregulated miRNAs in myeloma cells when directly co-cultured with pMSCs, and we show their contribution to changes in MCL-1 and BCL-2 protein expression and in the activity of S63845 and venetoclax. +genetics_GWAS 33805769 hsa-mir-188 Multiple Sclerosis We found that the protective allele of MS risk SNP rs4808760 reduces the expression of hsa-mir3p. +circulation_biomarker_diagnosis_ns 33805513 hsa-mir-122 Cholangiocarcinoma RESULTS Plasma miR-21 and miR-122 were significantly higher in iCCA patients than those in controls. +circulation_biomarker_diagnosis_ns 33805513 hsa-mir-21 Cholangiocarcinoma RESULTS Plasma miR-21 and miR-122 were significantly higher in iCCA patients than those in controls. +transcription factor target 33805203 hsa-mir-25 Alzheimer Disease 3p, hsa-miR-92a-3p, and hsa-miR-320a-3p were revealed in the groups of women with AIP (accreta, increta, percreta) relative to the group of women with scars on the uterus or to the group with placenta previa. +lncRNA target 33805203 hsa-mir-21 Alzheimer Disease "Opposite changes in the expression level of ""gene-target protein/miRNA"" pairs were found for the alpha-subunit of the clusterin secretory form and any of the hsa-miR" +transcription factor target 33805203 hsa-mir-17 Alzheimer Disease 3p, hsa-miR-92a-3p, and hsa-miR-320a-3p were revealed in the groups of women with AIP (accreta, increta, percreta) relative to the group of women with scars on the uterus or to the group with placenta previa. +lncRNA target 33805203 hsa-mir-20a Alzheimer Disease "Opposite changes in the expression level of ""gene-target protein/miRNA"" pairs were found for the alpha-subunit of the clusterin secretory form and any of the hsa-miR" +lncRNA target 33805203 hsa-mir-92a Alzheimer Disease "Opposite changes in the expression level of ""gene-target protein/miRNA"" pairs were found for the alpha-subunit of the clusterin secretory form and any of the hsa-miR" +circulation_biomarker_diagnosis_ns 33804927 hsa-mir-106a Colorectal Neoplasms Overall, we suggest a novel signature of four circulating miRNAs, i.e., miR +circulation_biomarker_diagnosis_ns 33804927 hsa-mir-542 Colorectal Neoplasms Overall, we suggest a novel signature of four circulating miRNAs, i.e., miR +circulation_biomarker_diagnosis_ns 33804927 hsa-mir-28 Colorectal Neoplasms Overall, we suggest a novel signature of four circulating miRNAs, i.e., miR +circulation_biomarker_diagnosis_ns 33804927 hsa-let-7e Colorectal Neoplasms Overall, we suggest a novel signature of four circulating miRNAs, i.e., miR +other 33804639 hsa-mir-21 Bronchiolitis Obliterans 5p downstream pathway. +transcription factor target 33804458 hsa-mir-200c Carcinoma, Ovarian Epithelial These findings provide new insights into how miR-200c-3p could be used to hold in check the adverse effects of conventional chemotherapy, targeted therapy and radiation therapy, and offer a novel therapeutic strategy for EOC. +lncRNA target 33804111 hsa-mir-146b Thyroid Cancer, Papillary In this work, a simple enzyme-free flow cytometric assay (termed as TSDR-based flow cytometric assay) has been developed for the detection of papillary thyroid carcinoma (PTC)-related microRNA (miRNA), hsa-miR-146b-5p with high performance through the toehold-mediated strand displacement reaction (TSDR) on magnetic beads (MBs). Moreover, the practicability of the assay was demonstrated by the analysis of hsa-miR-146b-5p amounts in different PTC cells and clinical PTC tissues. +genetics_GWAS 33804070 hsa-mir-618 Colonic Neoplasms The present study evaluated the prognostic role of circulating miRNA-618 in patients with metastatic colon cancer (mCC) and whether miR-618 gene rs2682818 single nucleotide polymorphisms (SNP) are associated with colon cancer susceptibility and expression levels of mature miR-618. miR-618 rs2682818 SNP significantly decreased the risk of colon cancer susceptibility in both heterozygous codominant (AC vs. +other 33804049 hsa-mir-204 Squamous Cell Carcinoma of Head and Neck This study provides a methodological platform for integrative biomarker studies based on simultaneous detection and quantification of miRs and/or protein and reveals stromal miR204 as a prognostic biomarker in OSCC. +circulation_biomarker_diagnosis_ns 33804042 hsa-mir-1 Myocarditis 3p in peripheral blood is increased in acute viral myocarditis, and this increase is correlated with myocardial damage and indicative of left ventricular systolic dysfunction in these patients. +circulation_biomarker_diagnosis_ns 33804042 hsa-mir-21 Myocarditis 3p in peripheral blood is increased in acute viral myocarditis, and this increase is correlated with myocardial damage and indicative of left ventricular systolic dysfunction in these patients. +genetics_GWAS 33803955 hsa-mir-222 Glioblastoma methylguanine-DNA methyltransferase (MGMT) methylation, IDH mutation status) and PORT as co-variables. +other 33803955 hsa-mir-19b Glioblastoma Expression of candidate miRs with prognostic relevance (miR-221/222; miR5p, miR-18a, miR-19b) was validated by qRT-PCR using Taqman technology on an independent validation cohort of GBM patients (n = 109) treated at Heidelberg University Hospital (HD cohort). +other 33803955 hsa-mir-18a Glioblastoma Expression of candidate miRs with prognostic relevance (miR-221/222; miR5p, miR-18a, miR-19b) was validated by qRT-PCR using Taqman technology on an independent validation cohort of GBM patients (n = 109) treated at Heidelberg University Hospital (HD cohort). +genetics_GWAS 33803955 hsa-mir-221 Glioblastoma methylguanine-DNA methyltransferase (MGMT) methylation, IDH mutation status) and PORT as co-variables. +other 33803955 hsa-mir-17 Glioblastoma Expression of candidate miRs with prognostic relevance (miR-221/222; miR5p, miR-18a, miR-19b) was validated by qRT-PCR using Taqman technology on an independent validation cohort of GBM patients (n = 109) treated at Heidelberg University Hospital (HD cohort). +other 33803354 hsa-mir-622 Carcinoma, Hepatocellular Together, miR-622 represents a superior regulator of both RAS-RAF-ERK as well as MAPK14-ATF2-signaling pathways in liver cancer. +circulation_biomarker_prognosis_up 33802346 hsa-mir-23a Carcinoma, Non-Small-Cell Lung The aim of the study was a search for diagnostic and/or prognostic biomarkers in patients with non-small cell lung cancer (NSCLC) patients, based on circulating microRNAs (miRs: miR-23a, miR-361, miR-1228 and miR-let7i) in extracellular vesicles (EVs). +other 33802122 hsa-mir-155 Multiple Sclerosis 5p for IgGs of patients of two types of MS-clinically isolated syndrome and relapsing-remitting MS-but was also high for patients with primary progressive and secondary progressive MS. +other 33801634 hsa-mir-29a Obesity, Maternal The objectives of this study were to examine the impact of maternal overweight/obesity on select miRNAs (miR-148a, miR-30b, miR-29a, miR-29b, miR-let-7a and miR-32) involved in adipogenesis and glucose metabolism and to examine the relationship of these miRNAs with measures of infant body composition in the first 6 months of life. +other 33801634 hsa-mir-29b Obesity, Maternal The objectives of this study were to examine the impact of maternal overweight/obesity on select miRNAs (miR-148a, miR-30b, miR-29a, miR-29b, miR-let-7a and miR-32) involved in adipogenesis and glucose metabolism and to examine the relationship of these miRNAs with measures of infant body composition in the first 6 months of life. +other 33801634 hsa-let-7a Obesity, Maternal The objectives of this study were to examine the impact of maternal overweight/obesity on select miRNAs (miR-148a, miR-30b, miR-29a, miR-29b, miR-let-7a and miR-32) involved in adipogenesis and glucose metabolism and to examine the relationship of these miRNAs with measures of infant body composition in the first 6 months of life. +other 33801634 hsa-mir-2 Obesity, Maternal The objectives of this study were to examine the impact of maternal overweight/obesity on select miRNAs (miR-148a, miR-30b, miR-29a, miR-29b, miR-let-7a and miR-32) involved in adipogenesis and glucose metabolism and to examine the relationship of these miRNAs with measures of infant body composition in the first 6 months of life. +other 33801634 hsa-mir-148a Obesity, Maternal The objectives of this study were to examine the impact of maternal overweight/obesity on select miRNAs (miR-148a, miR-30b, miR-29a, miR-29b, miR-let-7a and miR-32) involved in adipogenesis and glucose metabolism and to examine the relationship of these miRNAs with measures of infant body composition in the first 6 months of life. +tissue_expression_up 33801319 hsa-mir-221 Thyroid Cancer, Papillary miR-221, miR-222 expression was higher in the PTC tissue samples with extrathyroidal extension (p = 0.049, 0.003, respectively). +other 33801319 hsa-mir-21 Thyroid Cancer, Papillary A higher expression of miR-21 was related to unifocal lesions (p < 0.011) and autoimmune thyroiditis (0.007). +tissue_expression_ns 33801319 hsa-mir-181b Thyroid Cancer, Papillary We analyzed miR-146b, miR-21, miR-221, miR-21, and miR-181b in formalin fixed paraffin-embedded papillary thyroid carcinoma (PTC) tissue samples of 312 individuals and evaluated their expression relationship with clinicopathological parameters. +circulation_biomarker_diagnosis_up 33800868 hsa-mir-216 Prader-Willi Syndrome Higher relative expression of milk miRNA-216 was observed in the HTHH group (p < 0.05). These results suggest that early lactating cows are more vulnerable to short-term (4 day) high THI levels-that is, HTHH conditions-compared with LTLH, considering the enormous negative effects observed in measured blood metabolomics and parameters, milk yield and compositions, and milk miRNA-216 expression. +other 33800656 hsa-mir-139 Carcinoma, Hepatocellular In contrast, miR-30b-3p and miR3p were correlated with less occurrence of bone metastasis. +other 33800656 hsa-mir-139 Carcinoma, Renal Cell In contrast, miR-30b-3p and miR3p were correlated with less occurrence of bone metastasis. +genetics_GWAS 33800594 hsa-mir-155 Endometriosis PRC2 complex-JARID2 and PHF19 in endometriosis, providing an opportunity to test other epigenetic targets in endometriosis. +other 33800458 hsa-mir-21 Pre-Eclampsia 5p (1.62-fold change, p = 0.0005) in preeclamptic pregnancies, compared to controls. +other 33800458 hsa-mir-155 Pre-Eclampsia 5p (1.62-fold change, p = 0.0005) in preeclamptic pregnancies, compared to controls. +target gene 33800298 hsa-mir-584 Carcinoma, Non-Small-Cell Lung Tumor Suppressor miR-584-5p Inhibits Migration and Invasion in Smoking Related Non-Small Cell Lung Cancer Cells by Targeting YKT6. +other 33799789 hsa-mir-4790 Carcinoma, Hepatocellular It was also found that HCC tissues were characterized by higher expression of miR3p and lower expression of ZNF225; HCC tissues were also characterized by higher autophagic flux. +genetics_overexpression_promote 33798913 hsa-mir-106a Thyroid Cancer, Papillary Overexpressing HCG18 suppressed viability, migration, and invasion, promoted apoptosis, and inhibited miR-106a-5p expression in PTC cells. +lncRNA target 33798911 hsa-mir-129 Papillary Thyroid Microcarcinoma 5p could target FOXE1. +lncRNA target 33798550 hsa-mir-98 Stomach Neoplasms SIGNIFICANCE: This study revealed miR-98 inhibits gastric cancer cell stemness and chemoresistance by targeting BCAT1, suggesting that this miR-98/BCAT1 axis represents a potential therapeutic target in gastric cancer. +genetics_GWAS 33798547 hsa-mir-194 Triple Negative Breast Neoplasms Therefore, oleuropin represents a new nutri-epigenetic in immune-oncology that controls miR-194/XIST/PD-L1 loop in triple negative breast cancer. +lncRNA target 33798291 hsa-mir-155 Synovitis Compared with the model group, the increased levels of JSD and AI, and the expression levels of synovial miR-155, TLR4, MyD88, IRAK1, TRAF6, NF-kappaB, IL-1beta, TNF-alpha and IL-6 mRNA and protein were notably down-regulated in both moxibustion and antagonist groups (P<0.01). +lncRNA target 33798291 hsa-mir-155 Arthritis, Rheumatoid Compared with the model group, the increased levels of JSD and AI, and the expression levels of synovial miR-155, TLR4, MyD88, IRAK1, TRAF6, NF-kappaB, IL-1beta, TNF-alpha and IL-6 mRNA and protein were notably down-regulated in both moxibustion and antagonist groups (P<0.01). +genetics_overexpression_suppress 33797737 hsa-mir-22 Squamous Cell Carcinoma of Head and Neck 3p overexpression enhanced the inhibitory effect of siRNA-mediated LINC01137 silencing on OSCC cell proliferation, migration and invasion, whereas miR +lncRNA target 33797702 hsa-mir-17 Fibrosis, Renal In addition, downregulation of miR-17 could suppress renal fibrosis mediated by TGF-beta1 through targeting Smad7, which might be a clinical therapeutic target for patients with DN. +other 33797690 hsa-mir-146a Cholangiocarcinoma These data demonstrated that SNHG16 promoted cell proliferation and repressed apoptosis by regulating the miR-146a-5p/GATA6 axis, which provides some helpful insights for the diagnosis and treatment of CCA. +lncRNA target 33797188 hsa-mir-100 Urinary Bladder Neoplasms In conclusion, this study first constructed an immune-related prognostic lncRNA signature, which consists of RP11-89, PSORS1C3, LINC02672 and MIR100HG and might shed lights on novel targets for individualized immunotherapy for BLCA patients. +circRNA target 33797091 hsa-mir-874 Colorectal Neoplasms 3p targeted GDPD5 and upregulation of GDPD5 reversed the miR +genetics_overexpression_promote 33796959 hsa-mir-103 Enterovirus Infections Overexpression of miR-103 and miR-107 repressed EV71 replication by inhibiting EV71 titers and VP1 expression. +genetics_overexpression_promote 33796959 hsa-mir-107 Enterovirus Infections Overexpression of miR-103 and miR-107 repressed EV71 replication by inhibiting EV71 titers and VP1 expression. +genetics_overexpression_promote 33796457 hsa-mir-34a Lung Neoplasms In the current study, we first found that miR-34a was downregulated in Gejiu lung squamous carcinoma YTMLC-90, Xuanwei lung adenocarcinoma XWLC-05, and other non-small cell lung carcinoma (NSCLC) cell lines, and miR-34a overexpression inhibited cell proliferation, migration and invasion, as well as induced cell apoptosis in YTMLC-90 and XWLC-05 cells. In conclusion, our findings in the study confirmed that miR-34a overexpression could simultaneously suppress tumor growth and metastasis and play a vital role in tumorigenesis and progression of NSCLC via increasing PTEN and YY1 expression, but decreasing CDK6. +exosome 33795765 hsa-mir-532 Prostatic Neoplasms 5p in urine exosomes might be a potential biomarker for predicting BCR, which is a poor prognosis in patients with intermediate-risk prostate cancer. +exosome 33795521 hsa-mir-512 Glioblastoma These results suggest that BMSC-derived exosomes transport miR +exosome 33794884 hsa-mir-29a Osteosarcoma Macrophages-derived exosomal lncRNA LIFR-AS1 promotes osteosarcoma cell progression via miR-29a/NFIA axis. +exosome 33794833 hsa-mir-222 Colorectal Neoplasms In this investigation, we aimed to expound how the posttranscriptional regulation modulated by microRNA-222 (miR-222) from mesenchymal stem cells-derived extracellular vesicles (MSC-EVs) affected the AKT pathway and the immune escape in CRC. +circulation_biomarker_diagnosis_ns 33794782 hsa-mir-483 Metabolic Diseases We previously found that serum levels of miR +tissue_expression_ns 33794725 hsa-mir-130b Squamous Cell Carcinoma of Head and Neck We subsequently evaluated miR-130b expression in our clinical OPSCC cases. CONCLUSIONS AND SIGNIFICANCE: Our results suggest that miR-130b has potential as a biomarker for the radiosensitivity of HPV-negative OPSCC. +other 33794525 hsa-mir-22 Hypertension 3p level was significantly decreased in the thoracic aortic vascular tissues and aortic smooth muscle cells (ASMCs) of spontaneously hypertensive rats. +transcription factor target 33793771 hsa-mir-424 Colonic Neoplasms 5p suppressed epithelial-mesenchymal transition by inhibiting the Src/focal adhesion kinase signalling pathway to reduce 5-fluorouracil resistance in colon cancer cells. +lncRNA target 33792885 hsa-mir-455 Atrial Fibrillation 5p mimic accelerated the progression of AF by directly binding to its target gene suppressor of cytokines signaling 3 (SOCS3), leading to the activation of signal transducer and activator of transcription 3 (STAT3) signaling pathway. +lncRNA target 33792566 hsa-mir-122 Hepatic Insufficiency Further studies indicated that HIF1alpha-dependent induction of miR122 participated in a feed-forward pathway for liver protection via the enhancement of hepatic HIF responses through PHD1 repression. +lncRNA target 33792408 hsa-mir-369 Carcinoma, Hepatocellular 3p may be a tumor suppressor in HCC by targeting SOX4. +lncRNA target 33792033 hsa-mir-148a Hemoglobinuria, Paroxysmal identify miR-148a as a significant actor of the PC program that favors the differentiation through the inhibition of competitor fates, and supports the survival and fitness of the long-lived PC. In this commentary, we will discuss the place of miR-148a in the PC transcriptional network and its potential as a therapeutic target in PC-driven diseases. +transcription factor target 33792033 hsa-mir-148a Pathologic Processes In this commentary, we will discuss the place of miR-148a in the PC transcriptional network and its potential as a therapeutic target in PC-driven diseases. +genetics_knock down_promote 33791919 hsa-mir-27b Cicatrix, Hypertrophic Furthermore, knockdown of TUG1 significantly suppressed the fibrosis in HS via miR-27b-3p/TAK1/YAP/TAZ axis mediation. +other 33791304 hsa-mir-195 Triple Negative Breast Neoplasms 5p-CCNE1 axis promotes TNBC progress and may contribute to the novel diagnosis and treatment of TNBC. +genetics_knock down_promote 33791222 hsa-mir-1278 Colorectal Neoplasms We found that miR-1278 was downregulated in CRC samples, correlating with advanced clinical stage, and overexpression of miR-1278 led to tumor growth arrest and increased sensitivity to oxaliplatin via enhanced apoptosis and DNA damage. +genetics_overexpression_promote 33791206 hsa-mir-365a Stomach Neoplasms Overexpression of miR-365a-3p in GC cells significantly inhibited cell proliferation by inducing cell cycle arrest at G1 phase. +target gene 33791198 hsa-mir-935 Glioblastoma MicroRNA-935 Directly Targets FZD6 to Inhibit the Proliferation of Human Glioblastoma and Correlate to Glioma Malignancy and Prognosis. +genetics_overexpression_promote 33791049 hsa-mir-125 Colonic Neoplasms Overexpression of miR-125b-5p inhibited the proliferation, invasion, and autophagy of colon cancer cells and reversed the effects of CagA. +genetics_overexpression_promote 33791049 hsa-mir-125b Colonic Neoplasms Overexpression of miR-125b-5p inhibited the proliferation, invasion, and autophagy of colon cancer cells and reversed the effects of CagA. +circulation_biomarker_prognosis_ns 33791021 hsa-mir-129 Cardiomegaly The ROC curves suggested that serum NEAT1 and miR +target gene 33791016 hsa-mir-140 Carcinoma, Hepatocellular Inhibitory effect of miR-140-5p on doxorubicin resistance of hepatocellular carcinoma. +genetics_knock down_suppress 33791006 hsa-mir-181b Spinal Cord Injuries To conclude, the present results showed that SNHG14 knockdown alleviated PC-12 cell inflammation and apoptosis induced by LPS via regulating miR-181b-5p, which might provide a novel insight into the treatment of SCI. +transcription factor target 33790943 hsa-mir-197 Carcinoma, Hepatocellular Our findings demonstrate that the PPIAP22/miR3p/PPIA axis plays a vital role in the progression of HCC by increasing the malignancy of tumor cells and regulating the immune cell infiltration, especially macrophage, through CCL15-CCR1 or CXCL12-CXCR4/CXCR7 pathways. +circulation_biomarker_diagnosis_up 33790910 hsa-mir-155 Graft vs Host Disease In contrast, miR-146a and miR-155 were downregulated at D14 in serum EVs and at D7 in urine EVs in patients who developed aGvHD compared to those that remained disease-free, in both an exploratory (serum miR-155 p = 0.02, miR-146a p = 0.06; urine miR-155 p = 0.02, miR-146a p = 0.07) and an independent cohort (serum miR-155 p = 0.01, miR-146a p = 0.02). +circulation_biomarker_diagnosis_up 33790910 hsa-mir-146a Graft vs Host Disease In contrast, miR-146a and miR-155 were downregulated at D14 in serum EVs and at D7 in urine EVs in patients who developed aGvHD compared to those that remained disease-free, in both an exploratory (serum miR-155 p = 0.02, miR-146a p = 0.06; urine miR-155 p = 0.02, miR-146a p = 0.07) and an independent cohort (serum miR-155 p = 0.01, miR-146a p = 0.02). +lncRNA target 33790651 hsa-mir-149 Prostatic Neoplasms CONCLUSION: This research confirmed that by targeting and inhibiting RGS17, miR +lncRNA target 33790648 hsa-mir-1297 Cholangiocarcinoma "In addition, the function study showed that GAS5 acted as a ""sponge"" to downregulate hsa-miR-1297, thus modulating CCA cell proliferation and invasion. CONCLUSION: GAS5 acts as an endogenous sponge of hsa-miR-1297 to promote CCA cell proliferation and invasion, which might be a potential biomarker and therapeutic target for CCA." +genetics_knock down_suppress 33790646 hsa-mir-526b Colorectal Neoplasms CONCLUSION: Knockdown of circ_0071589 repressed CDDP resistance in CDDP-resistant CRC cells by regulating the miR-526b-3p/KLF12 axis. +target gene 33790645 hsa-mir-1290 Urinary Bladder Neoplasms Circular RNA_0000629 Suppresses Bladder Cancer Progression Mediating MicroRNA-1290/CDC73. +genetics_overexpression_promote 33790644 hsa-mir-26a Glioma Rapamycin substantially inhibited cell proliferation and cell percentage in the S phase and promoted cell apoptosis; miR-26a-5p inhibitor increased cell proliferation and cell cycle and decreased cell apoptosis; DAPK1 overexpression further induced cell proliferation, increased the cell number in the S phase, and inhibited apoptosis in glioma cells. CONCLUSION: Rapamycin exerts anti-tumor effects by promoting autophagy in glioma cells, which was dependent on the miR-26a-5p/DAPK1 pathway activation by rapamycin. +exosome 33790607 hsa-mir-125a Diabetic Nephropathies CONCLUSION: This study suggested that adMSC-derived exosomes inhibit DN progression and alleviate the symptoms by carrying miR-125a, during which HDAC1 and ET-1 were inhibited. +other 33790579 hsa-mir-483 pancreatic ductal adenocarcinoma Upregulated MicroRNA-483-3p is an Early Event in Pancreatic Ductal Adenocarcinoma (PDAC) and as a Powerful Liquid Biopsy Biomarker in PDAC. +other 33790405 hsa-mir-382 Schopf-Schulz-Passarge Syndrome MiR5p/rs4906032 and miR-15b-5/rs10936201 were associated with SSBP. +genetics_GWAS 33790405 hsa-mir-145 Sjogren's Syndrome In total, 24 miRNA-related SNPs were genotyped, four of which (miR +genetics_GWAS 33790405 hsa-mir-1307 Schopf-Schulz-Passarge Syndrome In total, 24 miRNA-related SNPs were genotyped, four of which (miR +genetics_GWAS 33790405 hsa-mir-4638 Schopf-Schulz-Passarge Syndrome In total, 24 miRNA-related SNPs were genotyped, four of which (miR +other 33790405 hsa-mir-382 Sjogren's Syndrome MiR5p/rs4906032 and miR-15b-5/rs10936201 were associated with SSBP. +genetics_GWAS 33790405 hsa-mir-1307 Sjogren's Syndrome In total, 24 miRNA-related SNPs were genotyped, four of which (miR +genetics_GWAS 33790405 hsa-mir-4638 Sjogren's Syndrome In total, 24 miRNA-related SNPs were genotyped, four of which (miR +other 33790405 hsa-mir-15b Sjogren's Syndrome MiR5p/rs4906032 and miR-15b-5/rs10936201 were associated with SSBP. +genetics_GWAS 33790405 hsa-mir-145 Schopf-Schulz-Passarge Syndrome In total, 24 miRNA-related SNPs were genotyped, four of which (miR +other 33790405 hsa-mir-15b Schopf-Schulz-Passarge Syndrome MiR5p/rs4906032 and miR-15b-5/rs10936201 were associated with SSBP. +other 33790326 hsa-mir-204 Squamous Cell Carcinoma of Head and Neck Up-regulation of miR-196a, miR-21, miR-1237 and downregulation of miR-204, miR-144 was associated with poor prognosis of OSCC patients. +other 33790326 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck Up-regulation of miR-196a, miR-21, miR-1237 and downregulation of miR-204, miR-144 was associated with poor prognosis of OSCC patients. +other 33790326 hsa-mir-144 Squamous Cell Carcinoma of Head and Neck Up-regulation of miR-196a, miR-21, miR-1237 and downregulation of miR-204, miR-144 was associated with poor prognosis of OSCC patients. +other 33790326 hsa-mir-196a Squamous Cell Carcinoma of Head and Neck Up-regulation of miR-196a, miR-21, miR-1237 and downregulation of miR-204, miR-144 was associated with poor prognosis of OSCC patients. +other 33790326 hsa-mir-1237 Squamous Cell Carcinoma of Head and Neck Up-regulation of miR-196a, miR-21, miR-1237 and downregulation of miR-204, miR-144 was associated with poor prognosis of OSCC patients. +genetics_overexpression_promote 33790078 hsa-mir-509 Uterine Cervical Neoplasms 3p overexpression significantly inactivated this pathway. +circulation_biomarker_diagnosis_ns 33789676 hsa-mir-1301 Nasopharyngeal Carcinoma qPCR was applied to verify the differences in the expressions of hsa-miR3p between 10 normal plasma and 10 NPC plasma samples. +lncRNA target 33789378 hsa-mir-139 Esophageal Squamous Cell Carcinoma 5p suppressed ESCC cell proliferation and invasion by targeting TBX1. +lncRNA target 33789360 hsa-mir-491 Pancreatic Carcinoma Additionally, LINC00460 promotes the aggressiveness of PDAC by targeting miR +genetics_knock down_suppress 33789359 hsa-mir-326 Glioma Moreover, transfection with miR-326 inhibitor counteracted SNHG9 knockdown-mediated inhibition of GSC cell growth. CONCLUSIONS: SNHG9 facilitates growth of GSCs via the miR-326/SOX9 axis. +other 33789319 hsa-mir-338 Urinary Bladder Neoplasms CONCLUSION: We speculate that hsa_circ_0008035/hsa-miR-107/MSRB3 and hsa_circ_0028173/hsa-miR3p/TPX2/GATA3 interaction pairs may play a vital role in BC. +other 33789319 hsa-mir-107 Urinary Bladder Neoplasms CONCLUSION: We speculate that hsa_circ_0008035/hsa-miR-107/MSRB3 and hsa_circ_0028173/hsa-miR3p/TPX2/GATA3 interaction pairs may play a vital role in BC. +other 33789312 hsa-mir-16 Urinary Bladder Neoplasms 5p and upregulating JARID2, providing novel insight into understating BC. +other 33788950 hsa-mir-299 Carcinoma, Hepatocellular Herein, qRT-PCR was employed for examining ZEB1-AS1, miR3p and E2F transcription factor 1 (E2F1) mRNA expressions in HCC cells and tissues. +circulation_biomarker_prognosis_ns 33788649 hsa-mir-596 Familial Primary Pulmonary Hypertension CONCLUSIONS High levels of plasma exosomal miR-596 were significantly associated with disease severity and poor prognosis of patients with IPAH. +lncRNA target 33788641 hsa-mir-200a Gastrointestinal Neoplasms RESULTS: miR-200a, miR-559, and miR-1236 were negatively associated with CD86, CD81, and CD160, respectively, in almost all types of gastrointestinal cancers, which were further verified in the in vitro studies by transfecting microRNA mimics in gastric cancer, colon cancer, pancreatic, and esophageal cell lines. CONCLUSION: Our study showed that miR-200a, miR-1236, and miR-559 are identified as cluster of differentiation-associated microRNAs in gastrointestinal cancers, providing a novel perspective to identify new therapeutic targets for cancer immunotherapy in gastrointestinal cancer patients. +lncRNA target 33788641 hsa-mir-1236 Gastrointestinal Neoplasms RESULTS: miR-200a, miR-559, and miR-1236 were negatively associated with CD86, CD81, and CD160, respectively, in almost all types of gastrointestinal cancers, which were further verified in the in vitro studies by transfecting microRNA mimics in gastric cancer, colon cancer, pancreatic, and esophageal cell lines. CONCLUSION: Our study showed that miR-200a, miR-1236, and miR-559 are identified as cluster of differentiation-associated microRNAs in gastrointestinal cancers, providing a novel perspective to identify new therapeutic targets for cancer immunotherapy in gastrointestinal cancer patients. +circulation_biomarker_diagnosis_ns 33788150 hsa-mir-205 Thyroid Neoplasms 5p and TSHR mRNA in serum of patients with thyroid carcinoma. +other 33788053 hsa-mir-20a Breast Neoplasms miR-20a was reported to induce mesenchymal to epithelial transition in MDA-MB-231 cells and its endogenous expression varies directly with invasiveness of breast cancer cells. +other 33788050 hsa-mir-486 beta-Thalassemia 3p) in high HbF thalassemia patients and correlate their levels with the patients' HbF levels then, in order to predict the exact role of the studied miRNAs in hematopoiesis, a bioinformatic analysis was carried out. +other 33788050 hsa-mir-96 beta-Thalassemia 3p) in high HbF thalassemia patients and correlate their levels with the patients' HbF levels then, in order to predict the exact role of the studied miRNAs in hematopoiesis, a bioinformatic analysis was carried out. +other 33788050 hsa-mir-15a beta-Thalassemia 3p) in high HbF thalassemia patients and correlate their levels with the patients' HbF levels then, in order to predict the exact role of the studied miRNAs in hematopoiesis, a bioinformatic analysis was carried out. +other 33788050 hsa-mir-16-1 beta-Thalassemia 3p) in high HbF thalassemia patients and correlate their levels with the patients' HbF levels then, in order to predict the exact role of the studied miRNAs in hematopoiesis, a bioinformatic analysis was carried out. +circulation_biomarker_diagnosis_down 33787515 hsa-mir-10b COVID-19 The expression of miR-10b was significantly downregulated in the peripheral blood of COVID-19 patients in comparison to the healthy controls (fold change= 0.12, P< 0.0001). +circulation_biomarker_diagnosis_ns 33787364 hsa-mir-17 Brain Injuries, Traumatic 92 cluster plasmid in enhancing tissue and neurological recovery compared with exosomes derived from MSCs transfected with an empty plasmid vector (Exo-empty) for treatment of TBI. +genetics_knock down_promote 33787082 hsa-mir-375 Squamous Cell Carcinoma of Head and Neck In addition, we demonstrated that miR-375 overexpression inhibited the luciferase activity of LUCAT1 wild-type and knockdown LUCAT1 promoted the miR-375 expression in TSCC cell. +other 33787061 hsa-mir-423 Squamous Cell Carcinoma of Head and Neck 5p was negatively associated with that of RPSAP52 in TSCC tissues. +genetics_overexpression_promote 33786745 hsa-mir-939 Glioma These findings indicated the overexpression of miR +lncRNA target 33786635 hsa-mir-27b Glioma In addition, microRNA (miR)27b is decreased in metastatic glioma. The present study investigated whether sevoflurane inhibited glioma cell progression by targeting miR27b. +genetics_overexpression_promote 33786634 hsa-mir-922 Liver Neoplasms ARID2 overexpression abrogated malignant behavior promoted by miR922 overexpression and enhanced miR922decreased malignant behavior of liver cancer cells. +lncRNA target 33786633 hsa-mir-216a Inflammation miR216a has been reported to be a potential therapeutic target in endothelial senescence and atherosclerosis via the Smad3/NFkappaB signaling pathway. Next, a replicative endothelial senescence model of HUVECs was established by infection with premiR216a recombinant lentiviruses (LvmiR216a) and the number of populationdoubling level (PDL) was calculated. +genetics_overexpression_promote 33786631 hsa-mir-34c Thyroid Neoplasms The overexpression of miR34c5p could inhibit the invasive and migratory abilities of THCA cells, in addition to inhibiting the cellular retinoic acid binding protein 2 (CRABP2) overexpressioninduced effects on invasion, migration and EMT processes. +genetics_knock down_promote 33786619 hsa-mir-25 Breast Neoplasms miR253p knockdown suppressed breast cancer cell proliferation and invasion, and transducer of ERBB2, 1 (TOB1) was identified as a potential target gene regulated by miR253p. +transcription factor target 33786608 hsa-mir-21 Aortic Aneurysm, Abdominal On the whole, the present study demonstrates that Dex inhibits AAA development by downregulating the miR21/PCDP4 axis. +circRNA target 33786605 hsa-mir-30 Osteosarcoma The low expression of miR3303p suppressed OS development. In conclusion, this study confirmed that by regulating the miR3303p/PNN axis, circular RNA circ_0032463 could function as a tumor enhancer in cells with OS. +exosome 33785732 hsa-mir-21 Acute Kidney Injury 5p-containing exosomes to alleviate sepsis-induced AKI through RUNX1 silencing. +exosome 33785732 hsa-mir-21 Sepsis 5p-containing exosomes to alleviate sepsis-induced AKI through RUNX1 silencing. +other 33785715 hsa-mir-375 Mouth Neoplasms We revealed a tendency to decreased miRNA-21 expression and increased miRNA-375 expression in tumors of patients with recurrence-free survival less than 12 months and the presence of metastatic lesions in regional lymph nodes. +other 33785715 hsa-mir-21 Mouth Neoplasms CONCLUSIONS The obtained results indicate the relation between the main clinical and pathological characteristics of patients with COC and the levels of miRNA-21 and -375 expression in tumor tissue, which indicates the involvement of these miRNAs in the formation of COC malignancy evidencing on their potential usefulness as additional prognostic markers. +circulation_biomarker_diagnosis_ns 33785399 hsa-mir-642a Osteoporosis, Postmenopausal The results suggest that characterizing plasma exosomal miRNA profiles of early postmenopausal women by small RNA sequencing could identify novel exo-miRNAs involved in bone remodeling, and miR-642a-3p maybe contribute to the prediction and diagnosis of early postmenopausal osteoporosis. +genetics_overexpression_promote 33785379 hsa-mir-107 Hypoxia Moreover, the activation of Wnt/beta-catenin and PI3K/AKT pathways triggered by H19 were reversed by miR-107 up-regulation in hypoxia-treated NSCs. CONCLUSION: LncRNA H19 overexpression attenuated hypoxia-induced NSCs injury and promoted activation of Wnt/beta-catenin and PI3K/AKT pathways through downregulating miR-107. +lncRNA target 33785336 hsa-mir-23b Stomach Neoplasms More importantly, DLEU2 contributed to GC progression via targeting miR-23b-3p/NOTCH2 axis. CONCLUSIONS: In summary, our research identified the STAT1/DLEU2/miR-23b-3p/NOTCH2/Notch axis in GC development, indicating that DLEU2 might function as a novel biomarker in GC. +genetics_overexpression_promote 33785332 hsa-mir-142 Breast Neoplasms 3p directly targets the 3' untranslated region of HMGA2, which encodes an onco-embryonic protein that is overexpressed in most cancers, including breast cancer. +other 33785202 hsa-mir-376a Enterocolitis, Necrotizing RESULTS: Multiple miRNAs, including miR-376a, miR-518a-3p and miR-604, were significantly altered when comparing NEC to non-NEC sepsis and healthy controls, and could potentially be used as specific NEC biomarkers. +other 33785202 hsa-mir-518a Enterocolitis, Necrotizing RESULTS: Multiple miRNAs, including miR-376a, miR-518a-3p and miR-604, were significantly altered when comparing NEC to non-NEC sepsis and healthy controls, and could potentially be used as specific NEC biomarkers. +genetics_overexpression_suppress 33785041 hsa-let-7a Nasal Polyps 5p mimic obviously reduced the protein levels of Ras, p-Raf1, p-MEK1 and p-ERK1/2, while IL-6 overexpression destroyed the inhibitory effect of let-7a-5p on the Ras-MAPK pathway in CRSwNP. +genetics_overexpression_suppress 33785041 hsa-let-7a Nasopharyngitis 5p mimic obviously reduced the protein levels of Ras, p-Raf1, p-MEK1 and p-ERK1/2, while IL-6 overexpression destroyed the inhibitory effect of let-7a-5p on the Ras-MAPK pathway in CRSwNP. +genetics_overexpression_promote 33784880 hsa-mir-101 Retinoblastoma 3p or overexpression of STC1 reversed the effect of si-HOTTIP on the proliferation and apoptosis of RB cells. +transcription factor target 33784796 hsa-mir-23a Oligospermia CONCLUSION: Findings indicate that the higher abundance level of miR-23a/b-3p and the lower abundance level of ODF2 and UBQLN3 targets are associated with oligoasthenozoospermia and male subfertility. +transcription factor target 33784796 hsa-mir-23b Oligospermia CONCLUSION: Findings indicate that the higher abundance level of miR-23a/b-3p and the lower abundance level of ODF2 and UBQLN3 targets are associated with oligoasthenozoospermia and male subfertility. +lncRNA target 33784470 hsa-mir-205 Uterine Cervical Neoplasms Conclusion: MiR-205 promotes CC cell viability, migration, and tube formation in vitro by targeting GATA3, providing new evidence for the implication of miR-205 in CC and a possible therapeutic method for CC. +lncRNA target 33784443 hsa-mir-124 Cicatrix, Hypertrophic 3p can inhibit the proliferation of HSFBs by targeting TGF-beta1, and miR +circulation_biomarker_diagnosis_ns 33784391 hsa-mir-203a Scleroderma, Systemic CONCLUSIONS: Our study links expression levels of the circulating plasma miRNAs, especially miR-20a-5p and miR-203a-3p, to the occurrence of SSc-APAH in female patients with ACA-positive lcSSc. +circulation_biomarker_diagnosis_ns 33784391 hsa-mir-20a Scleroderma, Systemic CONCLUSIONS: Our study links expression levels of the circulating plasma miRNAs, especially miR-20a-5p and miR-203a-3p, to the occurrence of SSc-APAH in female patients with ACA-positive lcSSc. +circulation_biomarker_diagnosis_ns 33784391 hsa-mir-20a Pulmonary Arterial Hypertension CONCLUSIONS: Our study links expression levels of the circulating plasma miRNAs, especially miR-20a-5p and miR-203a-3p, to the occurrence of SSc-APAH in female patients with ACA-positive lcSSc. +circulation_biomarker_diagnosis_ns 33784391 hsa-mir-203a Pulmonary Arterial Hypertension CONCLUSIONS: Our study links expression levels of the circulating plasma miRNAs, especially miR-20a-5p and miR-203a-3p, to the occurrence of SSc-APAH in female patients with ACA-positive lcSSc. +epigenetics 33784351 hsa-mir-190b Breast Neoplasms Integrated analysis identified certain DMLs whose methylation levels were significantly correlated with the expression of relevant miRNAs, such as multiple CpGs within miR-190b and miR-135b highly negatively correlated with their expression. +epigenetics 33784351 hsa-mir-135b Breast Neoplasms Integrated analysis identified certain DMLs whose methylation levels were significantly correlated with the expression of relevant miRNAs, such as multiple CpGs within miR-190b and miR-135b highly negatively correlated with their expression. +circulation_biomarker_prognosis_up 33784010 hsa-mir-361 Colorectal Neoplasms Moreover, the high expression of circulating exosomal miR +circRNA target 33784000 hsa-mir-141 Prostatic Neoplasms CONCLUSION: Our results suggest that circSOBP suppresses amoeboid migration of PCa cells and inhibits migration and invasion through sponging miR3p and regulating the MYPT1/p-MLC2 axis. +lncRNA target 33783995 hsa-mir-149 Carcinoma, Renal Cell 3p/CSF1 signaling via altering circEXOC7 or AR could lead to suppressing the RBM progression. +genetics_overexpression_promote 33783943 hsa-mir-21 Wounds and Injuries 5p facilitated wound healing while overexpression of RASA1 reversed the effect. +lncRNA target 33783940 hsa-mir-873 Carcinoma, Non-Small-Cell Lung 5p inhibition partially reversed the suppression of MCF2L-AS1 on the CSC-like traits on NSCLC cells. +genetics_overexpression_promote 33783904 hsa-mir-326 Carcinoma, Hepatocellular Moreover, PDK2 was a direct target of miR-326 and PDK2 overexpression abated the anti-cancer roles of miR-326 in HCC. +other 33783812 hsa-mir-16 Intracranial Aneurysm CONCLUSIONS AND CLINICAL IMPLICATIONS: MicroRNA-16 is a potential marker of IAs in renal transplant recipients with ADPKD. +transcription factor target 33783672 hsa-mir-205 Lung Neoplasms MiR-205 is involved in LC cell proliferation and migration by regulating PETN-mediated PI3K/AKT signal pathway, which may be a feasible treatment target for LC in clinical practice. +genetics_knock down_promote 33783609 hsa-mir-218 Osteoarthritis 5p overexpression reversed the protective effect of overexpression of KCNQ1OT1 or PIK3C2A on osteoarthritic chondrocytes. +circulation_biomarker_prognosis_ns 33783502 hsa-mir-210 Heart Failure, Acute CONCLUSIONS: Circulating miR-210 concentrations are associated with mortality, but do not add to established protein biomarkers for diagnosis or prognosis in patients with acute dyspnea. +circulation_biomarker_prognosis_ns 33783293 hsa-mir-487b Carcinoma, Hepatocellular RESULTS: The expression level of miR-487b in the serum of HBV-related HCC patients was significantly higher than that of CHB patients and normal healthy people. +lncRNA target 33782973 hsa-mir-122 Acute Kidney Injury CONCLUSIONS: Collectively, these studies provide evidence that miR-122 directly targets VDR in renal tubular cells, which strongly suggest that miR-122 up-regulation in the kidney under LPS challenge contributes to kidney injury by down-regulating VDR expression. +lncRNA target 33782807 hsa-mir-20b Pancreatic Carcinoma CONCLUSION OIP5-AS1 expedites the proliferative, migrated, and invasive capability of PC cells, while repressing cell apoptosis through regulating miRNA-320b/FOXM1 axis and FOXM1/Wnt/-catenin pathway in PC. +lncRNA target 33782806 hsa-mir-206 Carcinoma, Hepatocellular HCC cell line SMCC7721 was selected for co-transfection by si-SNHG14/miR-206 inhibitor/si-SOX9, followed by the measurement of cell proliferation using Cell Count Kit-8 (CCK-8) assay and clone formation assay. +circulation_biomarker_diagnosis_ns 33782502 hsa-mir-199 Muscular Atrophy Taken together, cell-free miR3p in the blood may have an anti-aging effect such as a hypertrophic effect in aged muscle fibers and could have potential as a novel RNA therapeutic for DMD as well as age-related diseases. +circulation_biomarker_diagnosis_ns 33782502 hsa-mir-199 Muscular Dystrophies Taken together, cell-free miR3p in the blood may have an anti-aging effect such as a hypertrophic effect in aged muscle fibers and could have potential as a novel RNA therapeutic for DMD as well as age-related diseases. +other 33782126 hsa-mir-218 Neurodegenerative Diseases microRNA-218 (miR-218) has been linked to several cognition related neurodegenerative and neuropsychiatric disorders. +other 33782126 hsa-mir-218-1 Neurodegenerative Diseases microRNA-218 (miR-218) has been linked to several cognition related neurodegenerative and neuropsychiatric disorders. +circRNA target 33782039 hsa-mir-889 Uterine Cervical Neoplasms 3p/HOXB7 axis, highlighting its significance as a potential therapeutic target for CC treatment. +lncRNA target 33781916 hsa-mir-433 Carcinoma, Hepatocellular CONCLUSIONS: Silencing of LINC01006 inhibited the viability, migration, and invasion of HCC cells through regulating miR +exosome 33781830 hsa-mir-4443 Carcinoma, Non-Small-Cell Lung The results showed that the microRNA-4443 (miR-4443) level was upregulated in cisplatin-resistant NSCLC tumor tissue-derived exosomes compared with cisplatin-sensitive tissue-derived exosomes. +other 33781391 hsa-mir-4734 Venous Thrombosis 5p and hsa-miR-4734 as the main regulators of messenger RNAs involved in the pathology of VTE. +other 33781391 hsa-mir-6789 Venous Thrombosis 5p and hsa-miR-4734 as the main regulators of messenger RNAs involved in the pathology of VTE. +other 33781391 hsa-mir-4651 Venous Thrombosis 5p and hsa-miR-4734 as the main regulators of messenger RNAs involved in the pathology of VTE. +other 33781391 hsa-mir-6765 Venous Thrombosis 5p and hsa-miR-4734 as the main regulators of messenger RNAs involved in the pathology of VTE. +lncRNA target 33781094 hsa-mir-1204 Breast Neoplasms Results: circKLHL24 and ALX4 were downregulated, while miR-1204 was upregulated in breast cancer tissues and cells. Conclusions: circKLHL24 blocked the progression of breast cancer by activating ALX4 through targeting miR-1204, which might be a novel perspective to understand the pathogenesis of breast cancer. +other 33780511 hsa-mir-21 Colorectal Neoplasms AIM: The aim of this study was to explore tumour-draining lymph node histomorphological changes and tumour pathological risk factors including the immunomodulatory microRNA-21 (miR-21) in a small cohort of stage II CRC. +other 33780352 hsa-mir-155 COVID-19 We also observed that microRNA (miR)-155 and miR-130a levels were markedly higher in the MM group compared to the SC group. +other 33780352 hsa-mir-130a COVID-19 We also observed that microRNA (miR)-155 and miR-130a levels were markedly higher in the MM group compared to the SC group. +genetics_knock down_promote 33780263 hsa-mir-199a Sarcoma, Ewing Finally, miR-199a-3p inhibitor or MSI2 overexpression counteracted the TUG1 knockdown-mediated inhibitory effect on Ewing's sarcoma cell proliferation, migration, and invasion. +genetics_overexpression_promote 33780108 hsa-mir-812 Blast Crisis Whereas overexpression of miR812w increased resistance to infection by the rice blast fungus Magnaporthe oryzae, CRISPR/Cas9-mediated MIR812w editing enhances disease susceptibility, supporting that miR812w plays a role in blast resistance. +transcription factor target 33779886 hsa-mir-23a Anemia, Aplastic Overall, BMSC-Exo could balance Th17/Treg ratio in aplastic anemia via suppressing IL-6 expression by transferring miR-23a-3p at least in part. +circulation_biomarker_diagnosis_ns 33779805 hsa-mir-23a Epilepsy We previously revealed that miR-23a-3p levels were elevated in the blood of patients with intractable epilepsy. +lncRNA target 33779805 hsa-mir-23a Brain Injuries A miR-23a-3p inhibitor was intracerebrally injected into VPA-resistant rats, and histological staining and Morris water maze tests were performed to evaluate brain damage and learning/memory functions in these rats. Intracerebral injection of a miR-23a-3p inhibitor reduced brain damage and the associated deficits in learning and memory functions in rats with VPA resistance. +other 33779112 hsa-mir-451 Hyperthyroidism CONCLUSIONS: Our findings showed that MDA, SOD and GSH levels increased, and miR-144 and miR-451 expressions changed in hyperthyroidism. +other 33778281 hsa-mir-486 Leukemia, Myelogenous, Chronic, BCR-ABL Positive miR-486-5p is A Prognostic Biomarker for Chronic Myeloid Leukemia. +circulation_biomarker_diagnosis_down 33778218 hsa-mir-210 Pre-Eclampsia The expression levels of miR-210 were validated using reverse transcription-quantitative PCR in plasma of severe PE (15) and mild PE (15) patients in comparison to controls subjects (15) with normal pregnancy. +other 33777926 hsa-mir-212 Pituitary Diseases 3p were demonstrated to be related to the occurrence of lubrication disorder. +other 33777926 hsa-mir-874 Pituitary Diseases 3p were demonstrated to be related to the occurrence of lubrication disorder. +other 33777862 hsa-mir-107 Fetal Growth Retardation By contrast, miRNA103-3p and miRNA107-3p, analyzed between the 32nd and 37th week of gestation, showed lower expression in the FGR group compared to aged matched controls. +other 33777862 hsa-mir-103 Fetal Growth Retardation By contrast, miRNA103-3p and miRNA107-3p, analyzed between the 32nd and 37th week of gestation, showed lower expression in the FGR group compared to aged matched controls. +other 33777742 hsa-mir-155 Lung Neoplasms Circular RNA CHST15 Sponges miR-155-5p and miR-194-5p to Promote the Immune Escape of Lung Cancer Cells Mediated by PD-L1. +other 33777742 hsa-mir-194 Lung Neoplasms Circular RNA CHST15 Sponges miR-155-5p and miR-194-5p to Promote the Immune Escape of Lung Cancer Cells Mediated by PD-L1. +genetics_overexpression_suppress 33777224 hsa-mir-1298 Uterine Cervical Neoplasms miR-1298 overexpression may be considered as a prognostic biomarker for cervical cancer and that miR-1298 may play an inhibitor role in cervical cancer by targeting NACC1. +genetics_overexpression_promote 33777219 hsa-mir-223 Nasopharyngeal Carcinoma Furthermore, it was suggested that DCLK1 overexpression may partially reverse the suppressive effects of miR +target gene 33777215 hsa-mir-125a Uterine Cervical Neoplasms MicroRNA-125a-5p targets LIM kinase 1 to inhibit cisplatin resistance of cervical cancer cells. +target gene 33777212 hsa-mir-365b Carcinoma, Non-Small-Cell Lung MicroRNA-365b-3p represses the proliferation and promotes the apoptosis of non-small cell lung cancer cells by targeting PPP5C. +lncRNA target 33777211 hsa-mir-599 Glioma Taken together, circ-ASPH/miR-599/AR/SOCS2-AS1 signaling may be a promising biomarker/therapeutic target for GM. +target gene 33777209 hsa-mir-217 Carcinoma, Non-Small-Cell Lung MicroRNA-217 inhibits the proliferation and invasion, and promotes apoptosis of non-small cell lung cancer cells by targeting sirtuin 1. +genetics_knock down_suppress 33777195 hsa-mir-641 Carcinoma, Hepatocellular Furthermore, RAB14 was identified as a target of miR-641, and RAB14 overexpression restrained the inducing effect of LINC00173 knockdown on HCC cell DDP sensitivity. +other 33777194 hsa-mir-145 Breast Neoplasms LINC00052 promotes breast cancer cell progression and metastasis by sponging miR-145-5p to modulate TGFBR2 expression. +lncRNA target 33777193 hsa-mir-23 Arthritis, Rheumatoid In conclusion, miR-23 inhibited inflammation to alleviate RA by regulating CXCL12 via the NF-kappaB signaling pathway, which may serve as a potential target for the diagnosis and treatment of RA. +lncRNA target 33777189 hsa-mir-23a Cataract For instance, miR-23a expression levels were shown to be upregulated in cataractous lenses; however, the function of miR-23a in cataracts remains undetermined. In conclusion, the findings of the current study suggested that the inhibition of miR-23a-3p may attenuate H(2)O(2)-induced cataract formation by targeting BCL2, thus providing a novel therapeutic target for the treatment of patients with cataracts in the clinic. +circulation_biomarker_diagnosis_ns 33777187 hsa-mir-145 Carotid Stenosis Serum SNHG1 and miR-145 expression levels were increased and decreased, respectively, in patients with restenosis (all P<0.001). +target gene 33777130 hsa-mir-22 Breast Neoplasms miR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγ. +genetics_GWAS 33776993 hsa-mir-21 Acquired Immunodeficiency Syndrome Also, mutation of the miR-21 binding site on exon 4 of GAS5 gene to generate a GAS5 mutant abolished its ability to regulate miR-21 expression as well as T cell activation and apoptosis markers compared to the wild-type GAS5 transcript. +other 33776905 hsa-mir-29c Epilepsy RESULTS: XIST expression and NFAT5 protein level was increased, whereas miR-29c-3p expression was decreased in the epilepsy rat model and LPS-treated CTX-TNA2 cells. +lncRNA target 33776787 hsa-mir-9 Osteoarthritis CONCLUSION: MEG3 can promote chondrocyte proliferation and migration and inhibit apoptosis and inflammation by sponging miR5p to induce KLF4 expression, which provides a promising therapy target for OA treatment. +genetics_knock down_promote 33776760 hsa-mir-140 Hyperglycemia Our current study suggested that the overexpression of circ_CLASP2 protected HUVEC from HG-induced dysfunction at least partly through the regulation of the miR +circulation_biomarker_diagnosis_ns 33776746 hsa-mir-21 Alzheimer Disease 3p plasma levels were significantly increased in AD patients compared to HC. +circulation_biomarker_diagnosis_ns 33776746 hsa-mir-146a Alzheimer Disease 3p, and -146a-5p was analyzed in plasma samples from 116 patients with AD compared with 41 age-matched healthy control (HC) subjects. +circulation_biomarker_diagnosis_ns 33776746 hsa-mir-126 Alzheimer Disease 3p plasma levels were significantly increased in AD patients compared to HC. +circulation_biomarker_diagnosis_ns 33776746 hsa-mir-17 Alzheimer Disease 3p plasma levels were significantly increased in AD patients compared to HC. +other 33776573 hsa-mir-708 Lung Diseases Therefore, we studied the relationship between miR-708, TNFalpha/IL-1beta, and AA signaling in diseased lung cells. We found that miR-708 negatively regulates TNFalpha/IL-1beta signaling in nondiseased lung cells, which is lost in diseased lung cells. +other 33776573 hsa-mir-708 Disease Therefore, we studied the relationship between miR-708, TNFalpha/IL-1beta, and AA signaling in diseased lung cells. We found that miR-708 negatively regulates TNFalpha/IL-1beta signaling in nondiseased lung cells, which is lost in diseased lung cells. +lncRNA target 33776485 hsa-mir-877 Stomach Neoplasms DISCUSSION: Our findings reveal that PROX1-AS1 exerts its role via miR +lncRNA target 33775754 hsa-mir-122 Hepatitis C MicroRNA-122 (miR-122), a liver-specific microRNA, has been implicated in the control of hepatitis C virus (HCV) RNA replication and its response to interferon (IFN) in human hepatoma cells. Here, we report that daidzein, a naturally occurring plant isoflavone, inhibits HCV replication and enhances the antiviral effect of IFN-alpha on HCV therapy by decreasing microRNA-122 levels in vitro without significantly affecting cell growth. +other 33775752 hsa-mir-20b Hepatitis B CONCLUSION: The MALAT1/hsa-miR-20b-5p/TXNIP axis may mediate CHB-induced inflammatory damage in chronic HBV infection complicated with NAFLD, and the mechanism may be related to the activation of NLRP3 inflammatory bodies and downstream inflammatory responses. +other 33775752 hsa-mir-20b Non-alcoholic Fatty Liver Disease CONCLUSION: The MALAT1/hsa-miR-20b-5p/TXNIP axis may mediate CHB-induced inflammatory damage in chronic HBV infection complicated with NAFLD, and the mechanism may be related to the activation of NLRP3 inflammatory bodies and downstream inflammatory responses. +lncRNA target 33775710 hsa-mir-196a Lung Neoplasms In lung adenocarcinoma patients, high miR-196a expression was associated with poor prognosis. Collectively, our results suggest that CAF-specific miR-196a promotes lung cancer progression in the tumor microenvironment via ANXA1 and CCL2 and that miR-196a will be a good therapeutic target or biomarker in lung adenocarcinoma. +other 33775690 hsa-mir-34a Neurodegenerative Diseases This finding hints at a crucial role of miR-34a-5p implicated in accelerating the pathogenesis of age-related neurological diseases. +transcription factor target 33775647 hsa-mir-337 Hyperlipidemias 3p might be a new therapeutic target for the development of antihyperlipidemic drug. +circulation_biomarker_prognosis_up 33775574 hsa-mir-140 Carcinoma, Hepatocellular We further used SP600125 or pSmad3L mutant plasmid to decrease pSmad3L level of hepatoma cells, and inhibition of pSmad3L increased miR +genetics_overexpression_promote 33775424 hsa-mir-628 Uterine Cervical Neoplasms Moreover, overexpression of VEGF could reverse the effects of miR +genetics_knock down_promote 33775353 hsa-mir-326 Medulloblastoma Rescue experiments showed that miR-326 inhibition reversed the effects of circ-SKA3 knockdown, and ID3 overexpression recovered MB cell proliferation, migration and invasion blocked by miR-326 restoration. In conclusion, circ-SKA3 functioned as an oncogene to promote the development of MB by increasing ID3 expression via decoying miR-326, hinting that circ-SKA3 might be a therapeutic target of MB. +lncRNA target 33775245 hsa-let-7i Carcinoma, Renal Cell CONCLUSION: Our results provide evidence that let-7i-5p functions as a tumor promoter in ccRCC and facilitates cell proliferation, migration and invasion by targeting HABP4. +other 33774143 hsa-mir-181b Neuralgia In conclusion, our study found that the lncRNA p21/miR-181b/Tnfaip1 axis probably plays an important role in the progression of neuropathic pain, among which lncRNA p21 may become a new insight in the treatment of neuropathic pain. +transcription factor target 33774032 hsa-mir-1 Endotoxemia The results showed that both AS-IV and the miR-1 inhibitor improved cardiac dysfunction, reduced heart injury, inhibited apoptosis and autophagy, and regulated the expression of calcium- and mitochondrial energy metabolism-related proteins in the heart tissue of rats treated with LPS. +transcription factor target 33774032 hsa-mir-1 Heart Diseases The results showed that both AS-IV and the miR-1 inhibitor improved cardiac dysfunction, reduced heart injury, inhibited apoptosis and autophagy, and regulated the expression of calcium- and mitochondrial energy metabolism-related proteins in the heart tissue of rats treated with LPS. +lncRNA target 33773992 hsa-mir-93 Colorectal Neoplasms CONCLUSION: miR-93 targeted HMGB3 to block the activation of the PI3K/AKT pathway and thus enhance CRC cell apoptosis. +transcription factor target 33773561 hsa-mir-20a Carcinoma, Non-Small-Cell Lung METHODS: In this study, the expression levels of miR-30d, miR5p and miR-20a as well as their target genes were analyzed in 30 non-small cell lung cancers (NSCLCs) patients sample and adjacent normal tissues by real-time qPCR. +transcription factor target 33773561 hsa-mir-204 Carcinoma, Non-Small-Cell Lung METHODS: In this study, the expression levels of miR-30d, miR5p and miR-20a as well as their target genes were analyzed in 30 non-small cell lung cancers (NSCLCs) patients sample and adjacent normal tissues by real-time qPCR. +circulation_biomarker_diagnosis_up 33773548 hsa-mir-106b Prostatic Neoplasms CONCLUSION: hsa-mir-106b-5p could modulate prostate cancer by interfering with the endoplasmic reticulum stress repair pathways and decreasing the expression of tumor suppressor genes involved in many biological processes. +target gene 33773546 hsa-mir-34a Breast Neoplasms And consequently, miR-34a inhibitor could be used safely as a tool to tackle drug resistance in breast cancer cells. +lncRNA target 33772768 hsa-mir-144 Osteoarthritis 3p mimic effectively ameliorated OA progression and reduced the numbers of IL-1beta-positive cells in synovial tissue. +lncRNA target 33772723 hsa-mir-28 Stomach Neoplasms Furthermore, propofol significantly inhibited the proliferation of gastric cancer cell line SGC-7901, where hsa-miR +other 33772703 hsa-mir-221 Obesity miR-126, miR-21, miR-146a, miR-221, and miR-223 resulted in the molecular signaling pathways that potentially involve in cellular adaption to exercise in people with obesity. +other 33772703 hsa-mir-126 Obesity miR-126, miR-21, miR-146a, miR-221, and miR-223 resulted in the molecular signaling pathways that potentially involve in cellular adaption to exercise in people with obesity. +other 33772703 hsa-mir-146a Obesity miR-126, miR-21, miR-146a, miR-221, and miR-223 resulted in the molecular signaling pathways that potentially involve in cellular adaption to exercise in people with obesity. +other 33772703 hsa-mir-21 Obesity miR-126, miR-21, miR-146a, miR-221, and miR-223 resulted in the molecular signaling pathways that potentially involve in cellular adaption to exercise in people with obesity. +circulation_biomarker_diagnosis_up 33772700 hsa-mir-6089 Retinoblastoma Furthermore, ROC curve analysis showed that miR-6089 in the plasma had a good sensitivity and specificity for distinguishing RB from the healthy control group. +other 33772408 hsa-mir-375 Endocrine System Diseases Our results highlight a critical role of miR-375 in regulating GnRH production, which may provide a novel potential therapeutic approach to neuroendocrine-disorder-related dysfunctions. +genetics_overexpression_suppress 33772297 hsa-mir-20 Carcinoma, Non-Small-Cell Lung However, overexpressed IRF6 neutralized the antineoplastic activities of miR-320 in lung cancer cells. +other 33772151 hsa-mir-195 Carcinoma, Hepatocellular METHODS: CHEK1 mRNA, protein, pri-miR-195 and miR-195 expression in HCC tissue was determined by qPCR, WB and IF staining assay. +other 33772151 hsa-mir-195 Endometrial Neoplasms METHODS: CHEK1 mRNA, protein, pri-miR-195 and miR-195 expression in HCC tissue was determined by qPCR, WB and IF staining assay. +other 33771980 hsa-mir-194 Carcinoma, Hepatocellular TEFM expression was significantly increased in HCC tissues mainly caused by down-regulation of miR5p. +exosome 33771969 hsa-let-7b Carcinoma, Hepatocellular In summary, this study demonstrated that Gli1-induced MIRLET7BHG facilitated HCC by activating HSCs through exosomal SMO to stimulate hedgehog pathway, providing a new road for HCC treatment. +other 33771844 hsa-mir-16 Colorectal Neoplasms SIGNIFICANCE STATEMENT: circ-keratin 6c could increase programmed cell death receptor ligand 1 expression by functioning as a microRNA5p sponge, which promoted malignant progression and immune evasion of colorectal cancer. +lncRNA target 33770685 hsa-mir-338 Rhinitis, Allergic 3p acts as an autophagy suppressor in PM2.5-exacerbated AR by directly targeting UBE2Q1 and affecting AKT/mTOR pathway. +lncRNA target 33770577 hsa-mir-222 Spinal Cord Injuries Circ_HIPK3 acted as a pathogenic inhibitor in the progression of SCI via the miR3p-mediated DUSP19 upregulation. +other 33770377 hsa-mir-21 Breast Neoplasms 5p and ZNF367 may serve as a future therapeutic approach to improve breast cancer prognosis. +transcription factor target 33770351 hsa-mir-192 Colonic Neoplasms 5p could target the largest number of CC genes. +transcription factor target 33770351 hsa-mir-215 Colonic Neoplasms 5p could target the largest number of CC genes. +transcription factor target 33770351 hsa-mir-193b Colonic Neoplasms 5p could target the largest number of CC genes. +transcription factor target 33770351 hsa-mir-16 Colonic Neoplasms 5p could target the largest number of CC genes. +lncRNA target 33770322 hsa-mir-25 Nasopharyngeal Carcinoma And more notably, miR-325 suppressed NPC progression in vitro by targeting CDCA5. Taken together, LINC01515 exerted the carcinogenic effect in NPC through regulating miR-325/CDCA5 pathway. +circulation_biomarker_diagnosis_ns 33770317 hsa-mir-423 Liver Neoplasms 3p expression was relatively low in patients with low TNM stage (I-II) and LC with serum AFP level 0.05) in the serum of SCD patients and significantly higher in the serum of MCI and DAT patients compared with the serum of the control group (P < 0.05). +other 33763423 hsa-mir-34a Substance Abuse, Intravenous METTL14 participates in the TNF-alpha-induced m6A modification of miR-34a-5p to promote cell senescence in HNPCs and NP cells of IVDD patients. +exosome 33763412 hsa-mir-132 Brain Ischemia The current study aimed to investigate the role of EV-derived miR-132 from MSCs in ischemic neuronal injury. Upregulation of EV-derived miR-132 released from MSCs attenuates ischemic neuronal injury by inhibiting Smad2/c-jun pathways via the suppression of Acvr2b. +genetics_GWAS 33763375 hsa-mir-21 Carcinoma, Hepatocellular 3p promotes migration and invasion of HCC cells and upregulation of YAP1 expression via direct inhibition of SMAD7, underscoring a major epigenetic mechanism in the pathogenesis of HCC. +circulation_biomarker_diagnosis_ns 33763302 hsa-mir-192 Polycystic Ovary Syndrome 5p are significantly differentially expressed in PCOS patients serum exosomes and identify these microRNAs as potential biomarkers for PCOS. +circulation_biomarker_diagnosis_ns 33763302 hsa-mir-6818 Polycystic Ovary Syndrome 5p are significantly differentially expressed in PCOS patients serum exosomes and identify these microRNAs as potential biomarkers for PCOS. +circulation_biomarker_diagnosis_ns 33763302 hsa-mir-1299 Polycystic Ovary Syndrome 5p are significantly differentially expressed in PCOS patients serum exosomes and identify these microRNAs as potential biomarkers for PCOS. +circulation_biomarker_prognosis_up 33763157 hsa-mir-629 Carcinoma, Non-Small-Cell Lung In conclusion, serum miR-629 might serve as a potential prognostic biomarker for NSCLC. +other 33763154 hsa-mir-145 Hyperglycemia miR-145 attenuated the HG-induced inflammatory response and OS injury in cardiomyocytes by negatively regulating ARF6, which may contribute to providing a theoretical basis for the treatment of diabetic cardiomyopathy. +lncRNA target 33763150 hsa-mir-29 Pulmonary Fibrosis CONCLUSION: Astragaloside IV combined with ferulic acid regulated the oxidative stress of lung tissues and TGF-beta1/Smad3 signaling through miR-29b, thereby reducing the degree of pulmonary fibrosis. +lncRNA target 33763150 hsa-mir-29b Pulmonary Fibrosis CONCLUSION: Astragaloside IV combined with ferulic acid regulated the oxidative stress of lung tissues and TGF-beta1/Smad3 signaling through miR-29b, thereby reducing the degree of pulmonary fibrosis. +genetics_GWAS 33762953 hsa-mir-424 Osteosarcoma LINC01116 Promotes Doxorubicin Resistance in Osteosarcoma by Epigenetically Silencing miR-424-5p and Inducing Epithelial-Mesenchymal Transition. +circRNA target 33762580 hsa-mir-1236 Adenocarcinoma of Lung 3p was expressed at low levels in LUAD, inhibited LUAD cell metastasis, and suppressed the function of circ-HMGA2. +lncRNA target 33762162 hsa-mir-20 Diabetic Retinopathy Further studies indicated that OGRU suppression greatly restored miR-320 expression, and a negative correlation between them was detected in DR patients. Collectively, these findings implicated that LncRNA-OGRU mediated DR progression through competing for miR-320 to regulate USP14 expression, and thus LncRNA-OGRU/miR-320/USP14 axis may be considered as a therapeutic target for DR treatment. +other 33761890 hsa-mir-409 Atherosclerosis 3p, are identified as the potentially critical biomarkers for AS. +other 33761890 hsa-mir-654 Atherosclerosis 3p, are identified as the potentially critical biomarkers for AS. +circulation_biomarker_prognosis_up 33761638 hsa-mir-26a Osteosarcoma Circulating miR-26a-5p level also been showed as independent risk factor for osteosarcoma in multivariate analysis (hazard ratio [HR], 0.38; 95% confidence interval [CI]: 0.11-0.98; P < .01).Circulating miR-26a-5p was significantly upregulated in osteosarcoma patients and remarkably associated with poor prognosis, indicating that circulating miR-26a-5p might serve as a useful diagnostic and prognostic biomarker for osteosarcoma. +genetics_GWAS 33761627 hsa-mir-34b Lung Neoplasms Hsa-miR-34b/c rs4938723 T > C, pri-miR1 rs531564 C > G and hsa-miR-423 rs6505162 C > A SNPs were not associated with lung cancer risk. +genetics_GWAS 33761627 hsa-mir-423 Lung Neoplasms Hsa-miR-34b/c rs4938723 T > C, pri-miR1 rs531564 C > G and hsa-miR-423 rs6505162 C > A SNPs were not associated with lung cancer risk. +genetics_GWAS 33761627 hsa-mir-124-1 Lung Neoplasms Hsa-miR-34b/c rs4938723 T > C, pri-miR1 rs531564 C > G and hsa-miR-423 rs6505162 C > A SNPs were not associated with lung cancer risk. +genetics_GWAS 33761627 hsa-mir-34c Lung Neoplasms Hsa-miR-34b/c rs4938723 T > C, pri-miR1 rs531564 C > G and hsa-miR-423 rs6505162 C > A SNPs were not associated with lung cancer risk. +circRNA target 33761622 hsa-mir-6873 Inflammation CONCLUSION: Kae alleviated ox-LDL-induced inflammation, oxidative stress, and apoptosis in HUVECs by regulating circNOL12/miR3p/FRS2 axis. +lncRNA target 33761588 hsa-mir-29b Aortic Aneurysm, Thoracic CONCLUSION: LncRNA Xist contributes to arterial smooth muscle cell apoptosis through miR-29b-3p/Eln pathway, providing new potential roads for treating TAA. +other 33761401 hsa-mir-30 Glioblastoma 5p could be potential biomarkers in GBM. +other 33761401 hsa-mir-485 Glioblastoma 5p could be potential biomarkers in GBM. +other 33760887 hsa-mir-212 Hypertension These results suggest that miR5p and PAFAH1B2 are novel negative regulators of VSMC proliferation, migration, and contraction in hypertension. +transcription factor target 33760254 hsa-mir-155 Tooth Diseases 5p inhibited OC differentiation by targeting CXCR2, thus reducing root resorption in orthodontics. +lncRNA target 33760216 hsa-mir-326 Thyroid Cancer, Papillary Thus, hsa_circ_0001666 may function as an oncogene, promoting PTC tumorigenesis via the miR3305p/miR193a5p/miR326/ETV4 pathway. +lncRNA target 33760216 hsa-mir-193a Thyroid Cancer, Papillary Thus, hsa_circ_0001666 may function as an oncogene, promoting PTC tumorigenesis via the miR3305p/miR193a5p/miR326/ETV4 pathway. +lncRNA target 33760216 hsa-mir-30 Thyroid Cancer, Papillary Thus, hsa_circ_0001666 may function as an oncogene, promoting PTC tumorigenesis via the miR3305p/miR193a5p/miR326/ETV4 pathway. +lncRNA target 33760215 hsa-mir-613 Carcinoma, Non-Small-Cell Lung Collectively, the results suggested a tumor suppressor role of miR613 in NSCLC and indicated that miR613 could strengthen CDDP sensitivity in NSCLC cells by targeting GJA1, which may provide a novel therapeutic target for NSCLC. +lncRNA target 33760213 hsa-mir-125a Lung Neoplasms Overall, the current study demonstrates that TSTA3 is regulated by miR125a5p and functions as an oncogene in lung cancer via promoting the activation of betacatenin signaling. +lncRNA target 33760211 hsa-mir-126 Sepsis Bioinformatics analysis predicted that the target of miR126 was epidermal growth factorlike domain multiple 6 (EGFL6) and dyskeratosis congenita 1 (DKC1) and these were confirmed by dualluciferase reporter assay. +genetics_knock down_promote 33760208 hsa-mir-1271 Carcinoma, Ovarian Epithelial circABCB10 and miR1271 expression levels were detected in EOC cells (OVCAR3, UWB1.289, SKOV3 and CAOV3) and normal ovarian epithelial cells (IOSE80) via reversetranscription quantitative PCR. +genetics_knock down_promote 33760207 hsa-mir-338 Retinoblastoma The results demonstrated that overexpression of miR3383p significantly inhibited cell proliferation, migration and invasion, and promoted apoptosis of the RB cells. +lncRNA target 33760204 hsa-mir-519d Uterine Cervical Neoplasms Therefore, the present results indicated that the miR519d3p/HIF2alpha axis increased DDP resistance of cervical cancer cells by suppressing the PI3K/AKT signaling pathway under hypoxic conditions. +genetics_knock down_promote 33760201 hsa-mir-122 Thyroid Cancer, Papillary Overexpression of miR1225p caused by miR1225p mimics inhibited the proliferation, invasion, and migration of the PTC cell line K1, while knockdown of miR1225p by miR1225p inhibitors exhibited the opposite effect. +genetics_overexpression_promote 33760190 hsa-mir-744 Glioma Overexpression of miR7445p inhibited the proliferation and invasiveness of glioma cells, which was rescued by LINC01116. +transcription factor target 33760189 hsa-mir-122 Non-alcoholic Fatty Liver Disease Therefore, it could be deduced that silibinin improved lipid metabolism by reducing the expression of miR122 and inhibiting the expression of miR122 may be a new therapeutic target to improve fatty liver disease. +lncRNA target 33760182 hsa-mir-495 hereditary lymphedema IA Taken together, these results suggested that MIAT may be involved in the differentiation of ADMSCs into LECs, and that the MIAT/miR495/Prox1 axis may be a novel regulatory mechanism and therapeutic target for the treatment of lymphedema. +lncRNA target 33760178 hsa-mir-222 Pneumonia, Mycoplasma The expression of GAS5, microRNA2223p, (miR2223p) and tissue inhibitor of metalloproteinases3 (TIMP3) in MPP was investigated using reverse transcriptionquantitative PCR. +genetics_overexpression_promote 33760169 hsa-mir-454 Carcinoma, Non-Small-Cell Lung Further mechanistic studies revealed that the inhibitory effects of miR4543p on NSCLC were reversed upon overexpression of TGFB2. +genetics_knock down_suppress 33760168 hsa-mir-128 Ovarian Neoplasms OIP5AS1 knockdown also inhibited tumor growth of OC in vivo by modulating the expression of miR1283p and CCNG1. +transcription factor target 33760167 hsa-mir-1271 Hepatitis B In conclusion, miR12715p blocked the progression of HBVinduced liver cancer by competitively targeting AQP5. +transcription factor target 33760167 hsa-mir-1271 Liver Neoplasms In conclusion, miR12715p blocked the progression of HBVinduced liver cancer by competitively targeting AQP5. +genetics_overexpression_promote 33760166 hsa-mir-101 Lupus Erythematosus, Systemic miR1013p overexpression attenuated the inflammatory response in SLE PBMCs by inhibiting the expression of MAPK1 and blocking the NFkappaB pathway. +transcription factor target 33760164 hsa-mir-93 Diabetes Mellitus, Type 2 The results demonstrated that miR935p expression was significantly increased and HGF expression was significantly decreased in HCC tissues isolated from patients with or without T2DM compared with adjacent healthy tissues isolated from patients without T2DM. Collectively, the results of the present study indicated that miR935p enhanced insulin resistance to regulate T2DM progression in HepG2 cells by targeting HGF. +genetics_overexpression_promote 33760159 hsa-mir-129 Colorectal Neoplasms miR129 overexpression significantly inhibited cell proliferation, migration, invasion and epithelialtomesenchymal transition (EMT), and it activated the nuclear factor (NF)kappaB signaling pathway in CRC cells, while the inhibition of miR129 exerted opposite effects. +lncRNA target 33760158 hsa-mir-128 Uterine Cervical Neoplasms Reverse transcriptionquantitative PCR was performed to detect FOXD3AS1, microRNA (miR)1283p and LIM domain kinase 1 (LIMK1) expression levels in CC tissues and cells. Therefore, the present study demonstrated that FOXD3AS1 upregulated LIMK1 expression via competitively sponging miR1283p in CC cells, promoting CC progression. +genetics_overexpression_suppress 33760151 hsa-mir-20a Pulmonary Fibrosis Briefly, overexpression of miR320a3p could inhibit the EMT process in PF by downregulating STAT3 expression. +transcription factor target 33760149 hsa-mir-143 Endometriosis Collectively, the results of the present study suggested that miR1433p inhibited EM progression, thus providing a novel target for the development of therapeutic agents against EM. +transcription factor target 33760137 hsa-mir-125b Nasopharyngeal Carcinoma It is the first study to reveal the inhibitory effect of tanshinone IIA on HK1 cells and to demonstrate the critical role of miR125b/foxp3 signaling in mediating these effects, providing robust evidence for the treatment of NPC. +lncRNA target 33760133 hsa-mir-181a Esophageal Squamous Cell Carcinoma The expression levels of TGFbeta1 and Smad4 in ESCC cell lines transfected with miR181a mimics and inhibitor were measured using RTqPCR and western blotting. +genetics_knock down_suppress 33760127 hsa-let-7c Squamous Cell Carcinoma of Head and Neck By applying bioinformatics analyses, micro RNA let7c5p was observed to physically bind with MIR4713HG, and the knockdown of let7c5p could counteract the influence of MIR4713HG on OTSCC. +circRNA target 33760126 hsa-mir-525 Colorectal Neoplasms CircRNA0074027 was upregulated in CRC tissues, while miR5253p expression was reduced. The downregulation of cirRNA_0074027 inhibited tumor progression via sponging miR5253p, which could be a promising treatment biomarker for CRC. +lncRNA target 33760118 hsa-mir-369 Pulmonary Fibrosis On the whole, the present study demonstrates that the silencing of DLEU2 suppressed IPF by upregulating miR3693p expression and downregulating TRIM2 expression. +genetics_knock down_promote 33760117 hsa-mir-520a Uterine Cervical Neoplasms Inhibition of CXCL8 in combination with miR302c3p and/or miR520a3p overexpression exerted proliferationsuppressive and apoptosisstimulating effects on CC cells, whereas restoring CXCL8 attenuated the miR302c3p and miR520a3pinduced antiproliferative and proapoptotic effects. +genetics_knock down_promote 33760113 hsa-mir-224 mucinous cystadenocarcinoma of pancreas Overexpression of miR2245p promoted the proliferation, migration and invasion of MCC and knockdown of miR2245p inhibited these functions. +genetics_knock down_promote 33760112 hsa-mir-124 AIDS-Related Complex The results of the present study demonstrated that miR-124 expression was significantly upregulated in ARC tissues, and knockdown of miR-124 increased SRA01/04 cell viability and suppressed apoptosis. +genetics_knock down_promote 33759638 hsa-mir-370 Thyroid Neoplasms Taken together, knockdown of circ_NEK6 repressed (131)I resistance in DTC cells by regulating the miR +genetics_overexpression_promote 33759399 hsa-mir-218 Radiation Injuries Overexpression of miRNA +lncRNA target 33759343 hsa-mir-216a Pancreatic Carcinoma To conclude, this study evidenced that miR-216a suppressed WT1 expression and blocked KRT7 transcription, which inactivated the PI3K/AKT signaling and reduced PC progression. +transcription factor target 33759195 hsa-mir-1246 Synovitis High expression of miR-1246 in M1-EVs from synovial fluid of patients with TMJ osteoarthritis and synovitis was verified by RT-PCR. +transcription factor target 33759195 hsa-mir-1246 Inflammation We then identified miR-1246 targets GSK3beta and Axin2 and found that miR-1246 inhibits GSK3beta and Axin2 expression, causing activation of the Wnt/beta-catenin pathway and inflammation in condylar chondrocytes. Our study found that M1-EVs promote inflammation by transfer of miR-1246 to condylar chondrocytes, thus providing new insight into one mechanism that can promote TMJ inflammation. +transcription factor target 33759195 hsa-mir-1246 Temporomandibular Joint Disorders High expression of miR-1246 in M1-EVs from synovial fluid of patients with TMJ osteoarthritis and synovitis was verified by RT-PCR. Our study found that M1-EVs promote inflammation by transfer of miR-1246 to condylar chondrocytes, thus providing new insight into one mechanism that can promote TMJ inflammation. +lncRNA target 33758932 hsa-mir-20b Lung Neoplasms We examined the effect of microRNA-320b (miR-320b) on tumor growth and angiogenesis in lung cancer and also determined its downstream molecular mechanisms. In conclusion, miR-320b suppresses lung cancer growth and angiogenesis by inhibiting HNF4G, IGF2BP2 and TK1. +other 33758783 hsa-mir-520b Lung Neoplasms FGF16 regulated by miR-520b enhances the cell proliferation of lung cancer. +other 33758620 hsa-mir-127 Melanoma 5p, has-miR-1913, and has-miR-1291) and 31 lncRNAs (FAM66C, MIAT, NR2F2AS1, etc.). +other 33758620 hsa-mir-374b Melanoma 5p, has-miR-1913, and has-miR-1291) and 31 lncRNAs (FAM66C, MIAT, NR2F2AS1, etc.). +other 33758620 hsa-mir-1913 Melanoma 5p, has-miR-1913, and has-miR-1291) and 31 lncRNAs (FAM66C, MIAT, NR2F2AS1, etc.). +other 33758620 hsa-mir-1291 Melanoma 5p, has-miR-1913, and has-miR-1291) and 31 lncRNAs (FAM66C, MIAT, NR2F2AS1, etc.). +lncRNA target 33758619 hsa-mir-502 Urinary Bladder Neoplasms Moreover, decreased miR5p obviously reversed the circNT5E silencing-mediated inhibition of Bca cell growth and migration. +lncRNA target 33758610 hsa-mir-145 Stomach Neoplasms Conclusions: Our findings indicate that the LINC00184/miR-145/ANGPT2 pathway has a crucial function in the development of GC and can act as a possible biomarker and targets for GC therapy. +lncRNA target 33758603 hsa-mir-32 Adenocarcinoma of Lung 5p may be a potential therapeutic target for the treatment of lung adenocarcinoma. +tissue_expression_ns 33758557 hsa-mir-122 Hepatitis C, Chronic Although microRNA-122 represents the majority of the microRNA content in hepatic tissues, few studies have evaluated its role in the treatment response, so we aimed to study its role in chronic HCV patients and in predicting the treatment response to direct-acting antivirals (DAAs). +lncRNA target 33758526 hsa-mir-20b Diabetic Retinopathy The expression of THBS1 was suppressed by siRNA to study the mechanism behind involvement of miR-20b-5p in DR. +target gene 33758511 hsa-mir-9 Carcinoma, Non-Small-Cell Lung Irradiation-Induced Activated Microglia Affect Brain Metastatic Colonization of NSCLC Cells via miR-9/CDH1 Axis. +genetics_knock down_suppress 33758101 hsa-mir-29a Glioblastoma In GBM cells, LOC646329 knockdown reduced miR-29a/b1 levels, and these cells exhibited decreased growth. +genetics_knock down_suppress 33758101 hsa-mir-29b-1 Glioblastoma In GBM cells, LOC646329 knockdown reduced miR-29a/b1 levels, and these cells exhibited decreased growth. +other 33757972 hsa-let-7a Post-Concussion Syndrome Additionally, a combined panel of 14 sncRNAs (let-7a-5p, miR3p, miR-103a-3p, miR-34b-3p, RNU6-7, RNU6-45, Snora57, snoU13.120, tRNA18Arg-CCT, U6-168, U6-428, U6-1249, Uco22cjg1,YRNA_255) could differentiate concussed subjects from all other groups, including players who were HIA- and controls, immediately after the game (AUC 0.91, 95% CI 0.81 to 1) and 36-48 hours later (AUC 0.94, 95% CI 0.86 to 1). +other 33757972 hsa-mir-34b Post-Concussion Syndrome Additionally, a combined panel of 14 sncRNAs (let-7a-5p, miR3p, miR-103a-3p, miR-34b-3p, RNU6-7, RNU6-45, Snora57, snoU13.120, tRNA18Arg-CCT, U6-168, U6-428, U6-1249, Uco22cjg1,YRNA_255) could differentiate concussed subjects from all other groups, including players who were HIA- and controls, immediately after the game (AUC 0.91, 95% CI 0.81 to 1) and 36-48 hours later (AUC 0.94, 95% CI 0.86 to 1). +other 33757972 hsa-mir-103a Post-Concussion Syndrome Additionally, a combined panel of 14 sncRNAs (let-7a-5p, miR3p, miR-103a-3p, miR-34b-3p, RNU6-7, RNU6-45, Snora57, snoU13.120, tRNA18Arg-CCT, U6-168, U6-428, U6-1249, Uco22cjg1,YRNA_255) could differentiate concussed subjects from all other groups, including players who were HIA- and controls, immediately after the game (AUC 0.91, 95% CI 0.81 to 1) and 36-48 hours later (AUC 0.94, 95% CI 0.86 to 1). +other 33757972 hsa-mir-143 Post-Concussion Syndrome Additionally, a combined panel of 14 sncRNAs (let-7a-5p, miR3p, miR-103a-3p, miR-34b-3p, RNU6-7, RNU6-45, Snora57, snoU13.120, tRNA18Arg-CCT, U6-168, U6-428, U6-1249, Uco22cjg1,YRNA_255) could differentiate concussed subjects from all other groups, including players who were HIA- and controls, immediately after the game (AUC 0.91, 95% CI 0.81 to 1) and 36-48 hours later (AUC 0.94, 95% CI 0.86 to 1). +lncRNA target 33757583 hsa-mir-135b Atherosclerosis CONCLUSION: CircRSF1 regulated ox-LDL-induced vascular endothelial cell proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in AS, providing new perspectives and methods for the treatment and diagnosis of AS. +lncRNA target 33757439 hsa-mir-148a Acquired Immunodeficiency Syndrome Regulatory microRNA, miR-148a-3p, was reduced in HIV positive patients (0.39-fold) with a concomitant increase in target ABCA1 (1.5-fold), which regulates cholesterol efflux. +lncRNA target 33757439 hsa-mir-148a Cholelithiasis Regulatory microRNA, miR-148a-3p, was reduced in HIV positive patients (0.39-fold) with a concomitant increase in target ABCA1 (1.5-fold), which regulates cholesterol efflux. +other 33757404 hsa-mir-21 Inflammation Our data exposes RA's potential as a pharmacological agent to manipulate miR-21 and counteract hyper-inflammatory response. +lncRNA target 33756273 hsa-mir-19b Atherosclerosis CONCLUSIONS: Collectively, the results show that HDAC3 upregulation prevents inflammation to inhibit AS by inactivating NF-kappaB/p65 via upregulation of miR-19b-mediated PPARgamma, providing a basic therapeutic consideration for AS treatment. +lncRNA target 33756228 hsa-mir-425 Stomach Neoplasms 3p inhibits immune escape of GC cells via elevation of ZC3H12A. +genetics_overexpression_promote 33756128 hsa-mir-155 Breast Neoplasms 5p inhibitors re-sensitized the paclitaxel-resistant breast cancer cells, while the overexpression of miR +genetics_knock down_promote 33756038 hsa-mir-519d Stomach Neoplasms Moreover, conditioned medium from stable knockdown H19 GC cells modulated the activity of immune cells including gammadeltaT cells, Jurkat cells, and tumor-associated macrophages in a miR-519d-3p/LDHA/lactate axis-dependent manner. +lncRNA target 33755911 hsa-mir-181a Cerebral Hemorrhage miR-181a was a significant mediator of post-ICH inflammation and is promising for further study, including as a potential therapeutic target. +genetics_knock down_promote 33755879 hsa-mir-486 Squamous Cell Carcinoma of Head and Neck Circ_0023028 knockdown might impede the progression of LSCC by regulating miR +other 33755848 hsa-mir-92a Carcinoma, Non-Small-Cell Lung HNF1AS1/miR-92a-3p/MAP2K4 axis plays important roles in radiotherapy resistance of NSCLC. +circulation_biomarker_diagnosis_ns 33755745 hsa-mir-369 Diabetes, Gestational In a clinical model of prediction of type 2 diabetes that included six traditional risk factors (age, BMI, pregnancy fasting glucose, postpartum fasting glucose, cholesterol and triacylglycerols), the addition of the circulating miR3p measured at 12 weeks postpartum improved the prediction of future type 2 diabetes from traditional AUC 0.83 (95% CI 0.68, 0.97) to an AUC 0.92 (95% CI 0.84, 1.00). +circulation_biomarker_diagnosis_ns 33755745 hsa-mir-369 Diabetes Mellitus, Type 2 In a clinical model of prediction of type 2 diabetes that included six traditional risk factors (age, BMI, pregnancy fasting glucose, postpartum fasting glucose, cholesterol and triacylglycerols), the addition of the circulating miR3p measured at 12 weeks postpartum improved the prediction of future type 2 diabetes from traditional AUC 0.83 (95% CI 0.68, 0.97) to an AUC 0.92 (95% CI 0.84, 1.00). +transcription factor target 33755271 hsa-mir-24 Atherosclerosis In conclusion, the present study indicated that theaflavins may achieve the anti-atherosclerotic effect via activating miRmediated Nrf2/HO-1 signaling pathway. +lncRNA target 33754051 hsa-mir-146a Alzheimer Disease In summary, our results provide sufficient evidence for the mechanism by which miR-146a opposes AD and strengthen the conclusion that miR-146a is a promising target for AD and other microglia-related diseases. +lncRNA target 33754032 hsa-mir-34a Carcinoma Model hBERA/miR-34a-5p and miR3p were selectively processed to warhead miRNAs in human carcinoma cells to modulate target gene expression, enhance apoptosis and inhibit invasiveness. +other 33754032 hsa-mir-34a Osteosarcoma In addition, bioengineered miR-34a-5p and miR3p agents both reduced orthotopic osteosarcoma xenograft tumor growth and spontaneous pulmonary metastases significantly. +other 33754032 hsa-mir-124 Osteosarcoma In addition, bioengineered miR-34a-5p and miR3p agents both reduced orthotopic osteosarcoma xenograft tumor growth and spontaneous pulmonary metastases significantly. +lncRNA target 33754032 hsa-mir-124 Carcinoma Model hBERA/miR-34a-5p and miR3p were selectively processed to warhead miRNAs in human carcinoma cells to modulate target gene expression, enhance apoptosis and inhibit invasiveness. +exosome 33754012 hsa-mir-10b Stomach Neoplasms Exosomal miR-10b-5p mediates cell communication of gastric cancer cells and fibroblasts and facilitates cell proliferation. +other 33753995 hsa-mir-16 Myelodysplastic Syndromes Reduced miR-16 levels are associated with VEGF upregulation in high-risk myelodysplastic syndromes. +lncRNA target 33753989 hsa-mir-25 Carcinoma, Hepatocellular Here we found that decreased AR could alter miR-325 to increase ACP5 expression in HCC cells, to increase HCC cells migration and invasion capacities. Together, these findings suggest that AR may decrease HCC progression through miR-325/ACP5 signaling and targeting the AR/miR-325/ACP5 signaling may help in the development of the novel therapies to better suppress the HCC progression. +genetics_overexpression_promote 33753875 hsa-mir-145 Prostatic Neoplasms In this study, we aimed at exploring the potential functions of CASC11 in association with miR-145 and IGF1R during the malignant progression of PCa cells. CONCLUSION: In summary, we found that CASC11 is upregulated in PCa cells and clinical tumor samples in comparison to corresponding controls and revealed that ectopic CASC11 overexpression promotes cellular phenotypes associated with PCa progression through CASC11/miR-145/IGF1R axis. +other 33753785 hsa-mir-365 Breast Neoplasms We therefore identified two miRNAs, namely miR-135b and miR-365, with a central role in regulating the altered functional pathways in basal breast cancer. +other 33753785 hsa-mir-135b Breast Neoplasms We therefore identified two miRNAs, namely miR-135b and miR-365, with a central role in regulating the altered functional pathways in basal breast cancer. +other 33753785 hsa-mir-135b Triple Negative Breast Neoplasms miR-135b and miR-365 have a key role in TNBC, controlling proliferation and invasion. +other 33753785 hsa-mir-365 Triple Negative Breast Neoplasms miR-135b and miR-365 have a key role in TNBC, controlling proliferation and invasion. +lncRNA target 33753463 hsa-mir-129-2 Adenocarcinoma of Lung Moreover, LINC01006 enhanced CTNNB1 via sequestering miR2-3p and activated the Wnt/beta-catenin pathway in LUAD. +lncRNA target 33753211 hsa-mir-520a Osteosarcoma Furthermore, we identified LINC01614 may promote the proliferation and invasion activities of OS cells, via binding miR-520a-3p and increase the expression of SNX3. We also proved that LINC01614 could function as competing endogenous RNAs and promote the proliferation, and invasion of OS cells through miR-520a-3p/SNX3 axis, and thus acts as a novel prognostic marker for OS in clinic. +lncRNA target 33753110 hsa-mir-30 Carcinoma, Non-Small-Cell Lung CONCLUSION: SNHG1 elevated DDP resistance and malignant potential of NSCLC cells through elevating the level of DCLK1 via sponging miR +tissue_expression_down 33753103 hsa-mir-155 Colorectal Neoplasms PMNs were found to promote HR deficiency in low-grade CRC by miRdependent downregulation of RAD51, thus attenuating tumor growth. +circulation_biomarker_diagnosis_up 33752480 hsa-mir-122 Stomach Neoplasms 5p was downregulated in exosomes derived from the serum of gastric cancer patients. +exosome 33752173 hsa-mir-222 Breast Neoplasms Our findings may provide a foundation for a promising strategy of BCa treatment by targeting exosomes or exosomal miR-222. +lncRNA target 33751900 hsa-mir-182 Endometrial Neoplasms 5p could target PIAS1 in EC. +genetics_overexpression_promote 33751897 hsa-mir-885 Stomach Neoplasms 5p, overexpressed in GC, associated with poor prognosis. +circRNA target 33751650 hsa-mir-142 Osteoarthritis 5p/SOX5 axis, providing possible targets for the clinical diagnosis and treatment of OA. +circulation_biomarker_diagnosis_up 33751108 hsa-mir-16-1 Neoplasms, Plasma Cell Taken together, our studies highlight the significant role of the miR-15a/16-1 cluster in the regulation of the GC reaction and its fundamental context-dependent tumor-suppression function in plasma cell and B-cell malignancies. +circulation_biomarker_diagnosis_up 33751108 hsa-mir-16 Neoplasms, Plasma Cell Taken together, our studies highlight the significant role of the miR-15a/16-1 cluster in the regulation of the GC reaction and its fundamental context-dependent tumor-suppression function in plasma cell and B-cell malignancies. +circulation_biomarker_diagnosis_up 33751108 hsa-mir-15a Neoplasms, Plasma Cell Taken together, our studies highlight the significant role of the miR-15a/16-1 cluster in the regulation of the GC reaction and its fundamental context-dependent tumor-suppression function in plasma cell and B-cell malignancies. +lncRNA target 33751053 hsa-mir-130b Muscular Diseases Thus, these results indicated that miR-130b may play a role in skeletal muscle regeneration and myopathy progression. Together, our findings suggest that the miR-130b/Sp1 axis may serve as a potential therapeutic target for the treatment of patients with muscle damage or severe myopathies. +other 33751053 hsa-mir-130b Muscular Dystrophies Moreover, miR-130b expression is declined in the muscle of muscular dystrophy patients. +lncRNA target 33750441 hsa-mir-503 Osteoarthritis CONCLUSION: In conclusion, our study demonstrated that HDAC2 could promote OA through miR +genetics_overexpression_promote 33750398 hsa-let-7a Cholangiocarcinoma Importantly, upregulation of either miR-1182 or let-7a induced autophagy, and inhibited cell progression and in vivo tumor growth and lung metastasis; moreover, combined treatment of miR-1182 and let-7a overexpression presented with enhanced inhibitory effect on NUAK1 expression and CCA progression, but such synergistic effect could be reversed by overexpression of NUAK1. +genetics_overexpression_promote 33750398 hsa-mir-1182 Cholangiocarcinoma Importantly, upregulation of either miR-1182 or let-7a induced autophagy, and inhibited cell progression and in vivo tumor growth and lung metastasis; moreover, combined treatment of miR-1182 and let-7a overexpression presented with enhanced inhibitory effect on NUAK1 expression and CCA progression, but such synergistic effect could be reversed by overexpression of NUAK1. +other 33750388 hsa-mir-223 Carcinoma, Renal Cell 3p, and hsa-miR-365a-3p) could be prognosis biomarkers for the prediction of KIRC patients. +other 33750388 hsa-mir-21 Carcinoma, Renal Cell 3p, and hsa-miR-365a-3p) could be prognosis biomarkers for the prediction of KIRC patients. +other 33750388 hsa-mir-365a Carcinoma, Renal Cell 3p, and hsa-miR-365a-3p) could be prognosis biomarkers for the prediction of KIRC patients. +lncRNA target 33750326 hsa-mir-4435-2 Colorectal Neoplasms CONCLUSIONS: MIR4435-2HG and ELFN1-AS1 are associated with prognosis and tumor-infiltrating immune cell types and could represent potential prognostic biomarkers or therapeutic targets in colorectal carcinoma. +other 33750300 hsa-mir-193b Intracranial Aneurysm Moreover, we found that several mRNAs (CCND1, HIF1A, E2F1, CDKN1A, VEGFA, COL1A1 and COL5A2) in the PVT1 subnetwork served as essential components in the PI3K-Akt signaling pathway, and that some of the non-coding RNAs (ncRNAs) (PVT1, HOTAIR, hsa-miR-17, hsa-miR-142, hsa-miR-383 and hsa-miR-193b) interacted with these mRNAs. +other 33750300 hsa-mir-383 Intracranial Aneurysm Moreover, we found that several mRNAs (CCND1, HIF1A, E2F1, CDKN1A, VEGFA, COL1A1 and COL5A2) in the PVT1 subnetwork served as essential components in the PI3K-Akt signaling pathway, and that some of the non-coding RNAs (ncRNAs) (PVT1, HOTAIR, hsa-miR-17, hsa-miR-142, hsa-miR-383 and hsa-miR-193b) interacted with these mRNAs. +other 33750300 hsa-mir-142 Intracranial Aneurysm Moreover, we found that several mRNAs (CCND1, HIF1A, E2F1, CDKN1A, VEGFA, COL1A1 and COL5A2) in the PVT1 subnetwork served as essential components in the PI3K-Akt signaling pathway, and that some of the non-coding RNAs (ncRNAs) (PVT1, HOTAIR, hsa-miR-17, hsa-miR-142, hsa-miR-383 and hsa-miR-193b) interacted with these mRNAs. +other 33750300 hsa-mir-17 Intracranial Aneurysm Moreover, we found that several mRNAs (CCND1, HIF1A, E2F1, CDKN1A, VEGFA, COL1A1 and COL5A2) in the PVT1 subnetwork served as essential components in the PI3K-Akt signaling pathway, and that some of the non-coding RNAs (ncRNAs) (PVT1, HOTAIR, hsa-miR-17, hsa-miR-142, hsa-miR-383 and hsa-miR-193b) interacted with these mRNAs. +genetics_overexpression_promote 33750228 hsa-mir-548b Melanoma As predicted, overexpression of miR-548b suppressed the growth and metastasis-associated traits of melanoma cells. +genetics_GWAS 33750005 hsa-mir-128-1 Intellectual Disability Thus, haploinsufficiency of R3HDM1 in the patient may be the cause of the mild ID due to the genetic imbalance between R3HDM1 and MIR128-1. +lncRNA target 33749639 hsa-mir-125b Pancreatic Carcinoma Also, over-expression of miR-125b encouraged migration, metastasis and proliferation of BxPC-3 cells, the suppression reversed it. +transcription factor target 33749631 hsa-mir-744 Triple Negative Breast Neoplasms Thus, targeting miR-744/eNOS/NO axis may act as a therapeutic tool in TNBC. +other 33749508 hsa-mir-552 Colonic Neoplasms After transfection with miR-552 mimic, colon cancer cell behaviors were re-evaluated. Anti-tumor role of sircSMARCA5 was showed in colon cancer cells as sponging miR-552 and blocking Wnt and YAP1 pathways. +other 33749138 hsa-mir-519b Femur Head Necrosis 5p-CCNT1 might play important roles in ONFH development. +other 33749138 hsa-mir-296 Femur Head Necrosis 5p-CCNT1 might play important roles in ONFH development. +other 33749138 hsa-mir-424 Femur Head Necrosis 5p-CCNT1 might play important roles in ONFH development. +transcription factor target 33748908 hsa-mir-337 Osteoporosis MiR-337 could repress osteogenic differentiation in high glucose-treated BMSCs directly targeting Rap1A, thus provide a potential therapeutic strategy for patients with diabetic osteoporosis in clinic. +transcription factor target 33748276 hsa-mir-138 Carcinoma, Hepatocellular In conclusion, all data from this study illustrate that miR-138 may as a tumor suppressor provides a potential treatment method to treating HCC. +lncRNA target 33748270 hsa-mir-5193 Pancreatic Carcinoma hsa-miR-5193 and hsa-miR3p targeting DUOX2 were forecasted from TargetScan, miRDB, and DIANA-TarBase databases, which were negatively correlated with OS (P = 0.043 and P = 0.0088, respectively) and DUOX2 expression (P = 0.0093 and P = 0.0032, respectively) in PC from TCGA data. +lncRNA target 33748270 hsa-mir-1343 Pancreatic Carcinoma hsa-miR-5193 and hsa-miR3p targeting DUOX2 were forecasted from TargetScan, miRDB, and DIANA-TarBase databases, which were negatively correlated with OS (P = 0.043 and P = 0.0088, respectively) and DUOX2 expression (P = 0.0093 and P = 0.0032, respectively) in PC from TCGA data. +transcription factor target 33748166 hsa-mir-210 Sepsis Conclusion: Quercetin antagonizes GF-induced renal injury by suppressing aerobic glycolysis via HIF-1alpha/miR-210/ISCU/FeS pathway in MCs cell model. +target gene 33748140 hsa-mir-9 Lung Neoplasms TAp63α Is Involved in Tobacco Smoke-Induced Lung Cancer EMT and the Anti-cancer Activity of Curcumin via miR-19 Transcriptional Suppression. +target gene 33748098 hsa-mir-3679 Lung Neoplasms M2 macrophage induce chemoresistance in lung cancer through MDE mediated miR-3679-5R/NEDD4L/c-Myc signaling cascade +other 33748004 hsa-mir-127 Thyroid cancer, medullary CONCLUSION: The miR-127 could be considered as a prognostic, diagnostic and therapeutic marker for the management of MTC, and it is proposed for further investigation to fully establish the role of this miRNA in MTC. +other 33747285 hsa-mir-16 Inflammation In this way, miR-16 would play a protective role against LPS-induced IDD and inflammation. +other 33747285 hsa-mir-16 Intervertebral disc disease In this way, miR-16 would play a protective role against LPS-induced IDD and inflammation. +lncRNA target 33747285 hsa-mir-16 Substance Abuse, Intravenous CONCLUSIONS: Our study suggested that, in NP cells of the IVD, miR-16 could exert inhibitory effects on the LPS-induced inflammatory response through NF-kappaB and MAPK pathways by directly mediating TAB3. +lncRNA target 33747283 hsa-mir-520b Gallbladder Neoplasms CONCLUSIONS: MiR-520b had suppressive effects on GBC via targeting RAB22A in vitro. +target gene 33747281 hsa-mir-338 Adenocarcinoma of Lung MiR-338-3p improved lung adenocarcinoma by AKAP12 suppression. +genetics_knock down_suppress 33747226 hsa-mir-27b Melanoma MYC knockdown in melanoma cells exerted similar effects to those of miR-27b overexpression on DNA synthesis, cell viability and invasive ability; the effects of miR-27b inhibition were significantly reversed by MYC knockdown. +target gene 33747224 hsa-mir-26a Breast Neoplasms MicroRNA-26a inhibits cell proliferation and invasion by targeting FAM98A in breast cancer. +transcription factor target 33747217 hsa-mir-140 Carcinoma, Adenoid Cystic 3p and its target genes may play an important role in LACC-HGT pathogenesis. +genetics_overexpression_promote 33747204 hsa-mir-1266 Carcinoma, Hepatocellular CCK-8 and Transwell assays demonstrated that overexpression of miR-1266 promoted the proliferation, migration and invasion of HCC cells. +lncRNA target 33747203 hsa-mir-203 Breast Neoplasms In summary, the present study demonstrated that miR-203 may directly target FKBP5 in breast cancer via fatty acid degradation and potential drugs, hence providing a novel treatment approach for breast cancer. +lncRNA target 33747202 hsa-mir-9 Carcinoma, Hepatocellular In conclusion, the findings of the present study demonstrated that lncRNA MEG3 affects HCC cell viability, apoptosis and migration through its targeting of miR +genetics_overexpression_promote 33747189 hsa-mir-211 Osteoarthritis In addition, overexpression of miR +therapeutic target 33747185 hsa-mir-126 Psoriasis lncRNA-HOTAIR/miR-126 axis may be implicated in the regulation of psoriasis progression and may serve as a potential therapeutic target for psoriasis. +transcription factor target 33747181 hsa-mir-584 Respiratory Distress Syndrome The present study provided a framework for understanding the molecular mechanisms of ARDS and suggested that miR-584 and miR-146a are associated with ARDS and may be potential therapeutic targets. +transcription factor target 33747181 hsa-mir-146a Respiratory Distress Syndrome The present study provided a framework for understanding the molecular mechanisms of ARDS and suggested that miR-584 and miR-146a are associated with ARDS and may be potential therapeutic targets. +transcription factor target 33747176 hsa-mir-383 Glioma In the current study, human glioma U87 cells were transfected with pre-/short hairpin (sh)-PRDX3 vectors and miR-383 mimics/inhibitors. +genetics_knock down_promote 33747155 hsa-mir-130a Uterine Cervical Neoplasms Functionally, compared with the corresponding control groups, miR-130a-3p knockdown, ERalpha overexpression and AR overexpression significantly inhibited CC cell proliferation and invasion, as demonstrated by the results obtained from the Cell Counting Kit-8 and Transwell assays in vitro. +lncRNA target 33747102 hsa-mir-203 Cerebral Infarction Taken together, our research provides a novel insight of the miRSLUG axis into cerebral infarction-associated endothelial behaviors and may offer a powerful therapeutic target of cerebral ischemia. +circulation_biomarker_diagnosis_ns 33746971 hsa-mir-221 Arthritis, Rheumatoid 5p, let-7i-5p) were significantly elevated in RA serum compared to HC (all p < 0.01) and 1 miRNA (miR +circulation_biomarker_diagnosis_ns 33746971 hsa-mir-431 Arthritis, Rheumatoid 5p, let-7i-5p) were significantly elevated in RA serum compared to HC (all p < 0.01) and 1 miRNA (miR +circulation_biomarker_diagnosis_ns 33746971 hsa-mir-24 Arthritis, Rheumatoid 5p, let-7i-5p) were significantly elevated in RA serum compared to HC (all p < 0.01) and 1 miRNA (miR +circulation_biomarker_diagnosis_ns 33746971 hsa-mir-130a Arthritis, Rheumatoid 5p, let-7i-5p) were significantly elevated in RA serum compared to HC (all p < 0.01) and 1 miRNA (miR +circulation_biomarker_diagnosis_ns 33746971 hsa-let-7d Arthritis, Rheumatoid 5p, let-7i-5p) were significantly elevated in RA serum compared to HC (all p < 0.01) and 1 miRNA (miR +transcription factor target 33746605 hsa-mir-7013 Melanoma, Experimental 3p inhibited melanin production, proliferation, and migration and promoted apoptosis in B16 melanoma cells. +transcription factor target 33746605 hsa-mir-7013 Melanoma 3p inhibited melanin production, proliferation, and migration and promoted apoptosis in B16 melanoma cells. +lncRNA target 33746585 hsa-mir-137 Reperfusion Injury Conclusion: QDG plays a neuroprotective role in ischemic stroke via regulation of the lncRNA GAS5/miR-137 signaling pathway. +other 33746583 hsa-mir-34b Asthenozoospermia Conclusion: This study firstly pooled several published studies and a GEO dataset to determine the significance of potential miRNAs and genes, such as miR-374b, miR-193a, miR-34b, BDNF, NTRK2, HNRNPD and EFTUD2 in regulating asthenozoospermia and underscore their interactions in the pathophysiological mechanism. +other 33746583 hsa-mir-374b Asthenozoospermia Conclusion: This study firstly pooled several published studies and a GEO dataset to determine the significance of potential miRNAs and genes, such as miR-374b, miR-193a, miR-34b, BDNF, NTRK2, HNRNPD and EFTUD2 in regulating asthenozoospermia and underscore their interactions in the pathophysiological mechanism. +exosome 33745232 hsa-mir-93 Sepsis 5p regulated the TXNIP directly to influence the pyroptosis in renal epithelial cells, which explained the functional difference between different phenotypes of macrophages. +exosome 33745232 hsa-mir-93 Acute Kidney Injury 5p regulated the TXNIP directly to influence the pyroptosis in renal epithelial cells, which explained the functional difference between different phenotypes of macrophages. +circulation_biomarker_diagnosis_up 33745222 hsa-mir-106a Glomerulonephritis, Membranous METHODS: The expression levels of miR-451a, miR-106a, miR-19b, and miR-17 in the serum of patients in the IMN group (n = 55, age: 50.2 /- 12.1 years) and the control group (n = 58, age 47.4 /- 13.1 years) were measured by quantitative real-time polymerase chain reaction (qRT-PCR), and the concentration of serum PTEN protein was determined by enzyme-linked immunosorbent assay (ELISA). +circulation_biomarker_diagnosis_up 33745222 hsa-mir-17 Glomerulonephritis, Membranous METHODS: The expression levels of miR-451a, miR-106a, miR-19b, and miR-17 in the serum of patients in the IMN group (n = 55, age: 50.2 /- 12.1 years) and the control group (n = 58, age 47.4 /- 13.1 years) were measured by quantitative real-time polymerase chain reaction (qRT-PCR), and the concentration of serum PTEN protein was determined by enzyme-linked immunosorbent assay (ELISA). +circulation_biomarker_diagnosis_ns 33745222 hsa-mir-451a Glomerulonephritis, Membranous BACKGROUND: To find new diagnostic markers for idiopathic membranous nephropathy (IMN) and also conduct preliminary explorations into the possible pathogenesis of IMN by comparing the expression of microRNA-451a (miR-451a), miR-106a, miR-19b, miR-17, and phosphatase and tensin homolog (PTEN) protein in the serum of patients with IMN and healthy controls. +circulation_biomarker_diagnosis_up 33745222 hsa-mir-19b Glomerulonephritis, Membranous METHODS: The expression levels of miR-451a, miR-106a, miR-19b, and miR-17 in the serum of patients in the IMN group (n = 55, age: 50.2 /- 12.1 years) and the control group (n = 58, age 47.4 /- 13.1 years) were measured by quantitative real-time polymerase chain reaction (qRT-PCR), and the concentration of serum PTEN protein was determined by enzyme-linked immunosorbent assay (ELISA). +other 33744906 hsa-mir-143 Glioma New treatment models to regulate the expression levels of NEAT1 and miR-143 will bring a new approach to the therapy of POG. +genetics_knock down_suppress 33744866 hsa-mir-590 Colorectal Neoplasms 3p overexpression exerted the same effects on the CRC cell phenotype as SNHG4 knockdown. +circRNA target 33744861 hsa-mir-30 Breast Neoplasms In conclusion, hsa_circ_0053063 inhibits breast cancer cell proliferation via hsa_circ_0053063/hsa-miR +genetics_knock down_suppress 33744851 hsa-mir-127 Colonic Neoplasms 3p in the colon cancer stem cell (CCSC) properties through gain- and loss-of function approaches. +other 33744767 hsa-mir-16 Lung Neoplasms For the construction of miRNA regulatory network, miR5p was related to all of these four genes, and its expression is significantly different between lung cancers and normal samples. +genetics_overexpression_suppress 33744723 hsa-mir-141 Carcinoma, Hepatocellular And overexpression of SLC16A1-AS1 attenuated the inhibitory effects of miR-141 on HCC cell proliferation. +genetics_GWAS 33744470 hsa-mir-3 Macular Degeneration Expression of the miR-33 target ATP-binding cassette transporter (ABCA1), a cholesterol efflux pump genetically linked to AMD, declined reciprocally in the RPE with age. These findings suggest that miR-33 targeting may decrease cholesterol deposition and ameliorate AMD initiation and progression. +lncRNA target 33744438 hsa-mir-26a Nasopharyngeal Carcinoma Moreover, miR-26a-5p inhibitor rescued the suppressive effect of SNHG6 depletion on NPC cell viability, migration and invasion. +genetics_knock down_promote 33744419 hsa-mir-186 Triple Negative Breast Neoplasms 5p and miR-200b-5p were consistently down- or up-regulated, respectively, after knockdown of FOXM1. +genetics_knock down_promote 33744419 hsa-mir-200b Triple Negative Breast Neoplasms 5p and miR-200b-5p were consistently down- or up-regulated, respectively, after knockdown of FOXM1. +lncRNA target 33744332 hsa-mir-363 Hypoxia-Ischemia, Brain 3p attenuates neonatal HIE by targeting DUSP5. +other 33744257 hsa-mir-223 Cataract Collectively, the data suggest a role for the KCNQ1OT1/miR3p/BCL2L2 axis in cataract formation but the data was generated using an epithelial cell line. +other 33743960 hsa-mir-146a Prostatic Neoplasms, Castration-Resistant Further, PTTG3P acted as a competing endogenous RNA (ceRNA, natural miRNA sponge) to upregulate PTTG1 expression by competing for mir-146a-3p in the progression to CRPC. +transcription factor target 33743404 hsa-mir-191 Diabetes Mellitus, Type 2 Thus, miR-191 blocking the translocation of GLUT4 was involved in arsenite-induced hepatic insulin resistance through inhibiting the IRS1/AKT pathway. +transcription factor target 33743404 hsa-mir-191 Liver Diseases Thus, miR-191 blocking the translocation of GLUT4 was involved in arsenite-induced hepatic insulin resistance through inhibiting the IRS1/AKT pathway. +other 33743313 hsa-mir-124 Fibrosis However, whether miR-124 could function as a transcriptional regulator in the inflammatory cytokines secretion of liver fibrosis remains unclear. In this study, we demonstrated that the expression of miR-124 was downregulated in liver fibrosis tissues and TNF-alpha-induced LX-2 cells, concomitant with the upregulated expression of IQGAP1, suggesting that miR-124 and IQGAP1 might be associated with the development of inflammation in liver fibrosis. +other 33743313 hsa-mir-124 Carcinoma, Hepatocellular Recent studies demonstrated that aberrant expression of miR-124 was involved in the progression of various liver diseases including hepatocellular carcinoma (HCC). +other 33743313 hsa-mir-124 Liver Diseases Recent studies demonstrated that aberrant expression of miR-124 was involved in the progression of various liver diseases including hepatocellular carcinoma (HCC). +transcription factor target 33743142 hsa-mir-128 Colorectal Neoplasms Moreover, B7-H3 was identified as a target of miR-128, and miR-128 negatively regulated B7-H3 expression in CRC cells. Besides, B7-H3 expression is negatively regulated by miR-128 in CRC. +other 33743120 hsa-mir-168 Polyomavirus Infections To conclude miR168 and miR162 are conserved among many plants and play a crucial role in evading virus infection which could be used as a potential candidate for developing antiviral strategies against potyvirid infections. +other 33743120 hsa-mir-162 Polyomavirus Infections To conclude miR168 and miR162 are conserved among many plants and play a crucial role in evading virus infection which could be used as a potential candidate for developing antiviral strategies against potyvirid infections. +other 33743111 hsa-mir-4257 Stomach Neoplasms 5p, and miR-5739). +lncRNA target 33743102 hsa-mir-129 Liver Cirrhosis 5p or downregulated PEG3 led to reduction of the histological changes of liver cirrhosis and lowered the apoptosis rate, via downstream effects on the NF-kappaB signaling pathway. +circulation_biomarker_diagnosis_up 33742996 hsa-mir-762 Nasopharyngeal Carcinoma RESULTS: The significant upregulation of miR-762 was observed in NPC serum compared with healthy controls, which was associated with the TNM stage and lymph node metastasis of NPC patients. +circulation_biomarker_diagnosis_ns 33742995 hsa-mir-485 Lupus Nephritis CONCLUSION: Serum miR +circulation_biomarker_diagnosis_ns 33742994 hsa-mir-194 Epilepsy, Temporal Lobe 5p was significantly dysregulated in plasma of TLE patients. +lncRNA target 33742606 hsa-mir-155 Carcinoma, Renal Cell Together, these findings indicate that hypoxia can promote the upregulation of miR-155 in EVs and that this miRNA can act in RCC cells to suppress FOXO3 expression, thereby enhancing cellular tumor progression. +lncRNA target 33742497 hsa-mir-188 Squamous Cell Carcinoma of Head and Neck 5p was one target of SNHG15 in OSCC cells. +lncRNA target 33742335 hsa-mir-363 Carcinoma, Non-Small-Cell Lung Taken together, lncRNA NORAD upregulated the expression of PEAK1 through sponging miR +lncRNA target 33742328 hsa-mir-186 Neuralgia In conclusion, inhibition of lncRNA PVT1 alleviates neuropathic pain in SCI rats by upregulating miR +other 33742265 hsa-mir-92a Coronary Artery Disease Several microRNAs (miRNAs) such as miRNA-92a (miR-92a) have been reported to negatively regulate angiogenesis in ischemic disease. +other 33741523 hsa-mir-326 Carcinoma, Hepatocellular Combined with patient survival data, several mRNAs and miRNAs, including CHST4, SLC22A8, STC2, hsa-miR-326, and hsa-miR-21 were identified from the network to predict HCC patient prognosis. +other 33741523 hsa-mir-21 Carcinoma, Hepatocellular Combined with patient survival data, several mRNAs and miRNAs, including CHST4, SLC22A8, STC2, hsa-miR-326, and hsa-miR-21 were identified from the network to predict HCC patient prognosis. +lncRNA target 33741494 hsa-mir-148a Carcinoma, Hepatocellular CONCLUSION: Our study elucidates that microRNA-148a-3p enhances the effects of sevoflurane on inhibiting proliferation, invasion and migration and enhancing apoptosis of HCC cells through suppression of ROCK1. +lncRNA target 33741416 hsa-mir-143 Cardiovascular Diseases SIGNIFICANCE: This study demonstrated a novel mechanism of glutamine in modulation of VSMC phenotypic switch by targeting miR-143 and THY1, and provides significant insight on targeted therapy of patients with cardiovascular diseases. +circulation_biomarker_diagnosis_ns 33741023 hsa-mir-106b Melanoma The serum level of exosomal miR-106b-5p is significantly increased in melanoma patients. +lncRNA target 33740948 hsa-mir-4429 Prostatic Neoplasms The putative target mRNA of miR-4429 involved in PCa progression was predicted from a bioinformatic system and validated through luciferase assays. +other 33740841 hsa-mir-137 Head and Neck Neoplasms RESULTS: Decreased expression of miR-137 (P<0.01) and miR-2682 (P<0.01) precursors was observed in cancerous tissues, most significantly in oropharyngeal tumors. +other 33740841 hsa-mir-2682 Head and Neck Neoplasms Here, we assessed the role of the MIR137/MIR2682 locus in HNSCC. CONCLUSION: The MIR137/MIR2682 locus correlated with HNSCC perineural invasiveness. +lncRNA target 33740340 hsa-mir-1179 Uterine Cervical Neoplasms In summary, our research indicated that the miR-1179 might regulate CHAF1A/ZEB1 axis and inhibit the invasion of cervical cancer cells. +genetics_knock down_promote 33739543 hsa-mir-129 Carcinoma, Renal Cell 3p knockdown and STAT3 overexpression decreased the protective effect of lncRNA SNHG1 knockdown on RCC cell immune escape. +circulation_biomarker_prognosis_up 33739050 hsa-mir-203a Carcinoma, Hepatocellular Therefore, our studies provided the novel insight into the role of serum miR-203a in HCC patients with HBV and potential new molecular target for early diagnosis of hepatitis B virus-related hepatocellular carcinoma. +lncRNA target 33739042 hsa-mir-449a Carcinoma, Hepatocellular The differential proteins screened by iTRAQ can provide the basis for studying the target proteins regulated by miR-449a and understanding the pathogenesis of HCC. +other 33739023 hsa-mir-21 Pulmonary Disease, Chronic Obstructive Our findings demonstrated that Th17 cells increased under COPD pathogenesis and was partially modulated by the miR-21/Smad7/TGF-beta pathway. +lncRNA target 33738672 hsa-mir-122 Carcinoma, Hepatocellular The lncRNA SNHG7 boosted the development of HCC by regulating FOXK2 through sponging miR +lncRNA target 33738662 hsa-mir-455 Hypoxia XIST could affect cell proliferation and apoptosis through miR3p/TIPARP axis in OGD-induced neuronal cells, providing a new regulatory network to understand the pathogenesis of hypoxia-induced neuronal injury. +genetics_overexpression_promote 33738662 hsa-mir-455 Osteochondritis Dissecans 3p, and overexpression of miR +lncRNA target 33738662 hsa-mir-455 Nerve Degeneration XIST could affect cell proliferation and apoptosis through miR3p/TIPARP axis in OGD-induced neuronal cells, providing a new regulatory network to understand the pathogenesis of hypoxia-induced neuronal injury. +transcription factor target 33738544 hsa-mir-145 Stomach Neoplasms pylori-infected GC through miR-145. +exosome 33738350 hsa-mir-501 Vascular Diseases Because exosomal microRNAs can travel to distant tissues and influence cell behavior, patients with elevated miR +circulation_biomarker_diagnosis_ns 33738350 hsa-mir-501 Arteriosclerosis This study investigated whether plasma exosome miR +other 33738254 hsa-mir-491 Thyroid Cancer, Papillary Protein and RNA expression analyses and immunohistochemistry detected the expression of NEAT1_2, Transglutaminase 2 (TGM2), and microRNA-491 (miR-491) among PTC and non-cancerous tissues. +exosome 33738143 hsa-mir-590 Colorectal Neoplasms 3p delivery via exosomes derived from CAFs enhances radioresistance in CRC through the positive regulation of the CLCA4-dependent PI3K/Akt signaling pathway. +genetics_knock down_suppress 33738140 hsa-mir-23a Memory Disorders The knockdown of miR-23a-3p may be a potentially valuable therapeutic strategy for estrogen deficiency-induced memory deficits. +other 33737947 hsa-mir-653 Stomach Neoplasms In addition, we identified eight RNAs associated with prognosis by multivariate Cox regression analysis, comprising three lncRNAs (AC094104.2, AC010457.1, and AC091832.1), two miRNAs (miR5p and miR-3923), and three mRNAs (C5orf46, EPHA8, and HPR); these were used to construct the prognostic prediction models, and their risk scores could be used to assess GC patients' prognosis. +other 33737947 hsa-mir-923 Stomach Neoplasms In addition, we identified eight RNAs associated with prognosis by multivariate Cox regression analysis, comprising three lncRNAs (AC094104.2, AC010457.1, and AC091832.1), two miRNAs (miR5p and miR-3923), and three mRNAs (C5orf46, EPHA8, and HPR); these were used to construct the prognostic prediction models, and their risk scores could be used to assess GC patients' prognosis. +genetics_overexpression_promote 33737813 hsa-mir-34a Carcinoma, Pancreatic Ductal Moreover, knocking down HOTAIR or overexpressing miR-34a significantly inhibited CSCs-like properties, invasion and migration of PDAC cells. +lncRNA target 33737811 hsa-mir-619 Colonic Neoplasms CONCLUSION: The present study demonstrated that ILF3-AS1 plays an oncogenic role in COAD through regulating the miR5p/CAMK1D axis, and inhibition of ILF3-AS1 may pave the way for COAD treatment. +exosome 33737514 hsa-mir-129 Anxiety Disorders Notably, the expression level of exosomal hsa-miR +exosome 33737514 hsa-mir-363 Depression Notably, the expression level of exosomal hsa-miR +exosome 33737514 hsa-mir-363 Anxiety Disorders Notably, the expression level of exosomal hsa-miR +exosome 33737514 hsa-mir-363 Substance-Related Disorders Notably, the expression level of exosomal hsa-miR +exosome 33737514 hsa-mir-16 Depression Notably, the expression level of exosomal hsa-miR +exosome 33737514 hsa-mir-16 Anxiety Disorders Notably, the expression level of exosomal hsa-miR +exosome 33737514 hsa-mir-16 Substance-Related Disorders Notably, the expression level of exosomal hsa-miR +exosome 33737514 hsa-mir-92a Anxiety Disorders Notably, the expression level of exosomal hsa-miR +exosome 33737514 hsa-mir-129 Substance-Related Disorders Notably, the expression level of exosomal hsa-miR +exosome 33737514 hsa-mir-92a Depression Notably, the expression level of exosomal hsa-miR +exosome 33737514 hsa-mir-92a Substance-Related Disorders Notably, the expression level of exosomal hsa-miR +exosome 33737514 hsa-mir-129 Depression Notably, the expression level of exosomal hsa-miR +genetics_knock down_promote 33737500 hsa-mir-9 Hypoxia Moreover, CDK8 was identified to be target of miR-9, and CDK8 knockdown could reverse the effects of miR-9 inhibitor on cell proliferation, damage and apoptosis in hypoxia-treated H9c2 cells. +transcription factor target 33737500 hsa-mir-9 Heart Diseases In conclusion, miR-9 repressed cell proliferation and promoted cell damage and apoptosis by binding to CDK8 through the Wnt/ beta-catenin pathway in hypoxic-induced H9c2 cells, which provided a new direction for further studying the treatment of hypoxia-aroused heart diseases. +genetics_knock down_promote 33737494 hsa-mir-1244 Ovarian Neoplasms Circ_0002711 knockdown hampered ROCK1 expression by upregulating miR-1244 expression. +lncRNA target 33737493 hsa-mir-381 Squamous Cell Carcinoma of Head and Neck 3p inhibition could attenuate YAP1 deletion-induced suppression on cell malignant biological behavior in OSCC. +lncRNA target 33737240 hsa-mir-552 Hyperlipidemias 3p as a new PCSK9 inhibitor with the dual-inhibition mechanism, which suggested the possible application of miR +other 33737086 hsa-mir-23b Aortic Aneurysm SIGNIFICANCE: Our study revealed a pivotal role for miR-23b in protecting against aortic aneurysm formation by maintaining the VSMC contractile phenotype. +other 33736615 hsa-mir-513b Pancreatic Carcinoma CONCLUSIONS: FTX could directly combine with miR-513b-5p as a competitive endogenous RNA, thus promoting the occurrence and development of PC in vitro and in vivo. +circulation_biomarker_diagnosis_down 33736417 hsa-mir-155 Immune System Diseases Our novel evaluation of miR-155 in peregrine nestlings identified significantly negative relationships of plasma miR-155 counts with PFHxS and PFOA concentrations, indicating potential down-regulation of miR-155 expression and impaired immunity. +lncRNA target 33735868 hsa-mir-125a psoriasis 1 CONCLUSION: miR-125a could facilitate the disease monitoring and probably has the potential to be a therapeutic target in psoriasis. +other 33735827 hsa-mir-132 Aspergillosis, Allergic Bronchopulmonary miRNA-132 has a role in ABPA detection and distinguishing ABPA from allergic asthma and SAFS. +lncRNA target 33735715 hsa-mir-877 Respiratory Distress Syndrome kinase and AKT (PI3K/Akt) signaling pathway. +genetics_knock down_promote 33735626 hsa-mir-192 Leukemia, Myeloid, Acute In conclusion, circ_0005774 knockdown repressed cell proliferation and promoted apoptosis of AML cells partially through regulating miR +lncRNA target 33735119 hsa-mir-206 Carcinoma, Hepatocellular In summary, the results demonstrated that miR-206 could inhibit lipid accumulation and growth of HCC cells by targeting G6PD, suggesting that the miR +genetics_knock down_promote 33735118 hsa-mir-149 Ovarian Neoplasms 5p overexpression suppressed paclitaxel resistance and cell progression in paclitaxel-resistant ovarian cancer cells by interacting with SIK2. +genetics_knock down_suppress 33735116 hsa-mir-637 Colorectal Neoplasms Importantly, knockdown of WNT1 reversed the carcinogenic effects mediated by miR-637 inhibitor in CRC cells treated with sevoflurane. +lncRNA target 33735107 hsa-mir-338 Uterine Cervical Neoplasms Taken altogether, our results showed that circ_0000326 exerted oncogenic effects on cervical cancer by upregulating Cyclin-dependent kinase 4 via sponging microRNA3p. +other 33734019 hsa-mir-107 Obesity An additional miRNA (miR-107), measured in late pregnancy, was positively associated with GA at birth in infants born to obese women (P(FDR) for BMI interaction = 0.011). +genetics_knock down_promote 33734009 hsa-mir-197 Hamartoma Syndrome, Multiple 3p abrogated the inhibitory effect on CC cell proliferation, migration and invasion induced by circ-ZNF609 knockdown. +genetics_knock down_suppress 33733860 hsa-mir-187 Carcinoma, Non-Small-Cell Lung 3p was demonstrated to rescue circCCND1 knockdown-modulated chemoresistance of NSCLC cells. +lncRNA target 33733597 hsa-mir-138 Osteoporosis, Postmenopausal Therefore, it can be concluded that oestrogen deficiency could induce the apoptosis of osteoblasts and lead to osteoporosis in post-menopausal females via modulation of the HOTAIR/miR-138/TIMP1 signalling axis. +lncRNA target 33733589 hsa-mir-21 Femur Head Necrosis In conclusion, CircPVT1 exerts protective effects against SIONFH via modulating miR +transcription factor target 33733575 hsa-mir-21 Fatty Liver In conclusion: QUR prevents CdCl2 -induced hepatic steatosis and fibrosis mainly through attenuating its ability to upregulate miR-21, at least, by upregulation of Nrf2. +transcription factor target 33733575 hsa-mir-21 Diabetic Nephropathies In conclusion: QUR prevents CdCl2 -induced hepatic steatosis and fibrosis mainly through attenuating its ability to upregulate miR-21, at least, by upregulation of Nrf2. +other 33732700 hsa-let-7c Cleft Palate Conclusions: Let-7c-5p-PIGA and miR-193a-3p-TGFB2 networks may be involved in the development of NSCL/P. +other 33732700 hsa-mir-193a Cleft Palate Conclusions: Let-7c-5p-PIGA and miR-193a-3p-TGFB2 networks may be involved in the development of NSCL/P. +other 33732700 hsa-mir-193a Cleft Palate, Non-Syndromic Conclusions: Let-7c-5p-PIGA and miR-193a-3p-TGFB2 networks may be involved in the development of NSCL/P. +other 33732700 hsa-let-7c Cleft Palate, Non-Syndromic Conclusions: Let-7c-5p-PIGA and miR-193a-3p-TGFB2 networks may be involved in the development of NSCL/P. +exosome 33732698 hsa-mir-15a Colorectal Neoplasms MicroRNA-15a Carried by Mesenchymal Stem Cell-Derived Extracellular Vesicles Inhibits the Immune Evasion of Colorectal Cancer Cells by Regulating the KDM4B/HOXC4/PD-L1 Axis. +lncRNA target 33732386 hsa-mir-15a Carcinoma, Endometrioid Mechanistic investigation revealed that miR-15a-5p inhibited EC development via regulation of Wnt/beta-catenin pathway and targeting of VEGFA. +therapeutic target 33732376 hsa-mir-153 Pancreatic Neoplasms miR-153 enhances the therapeutic effect of radiotherapy by targeting JAG1 in pancreatic cancer cells. +other 33732373 hsa-mir-495 Adenocarcinoma of Lung These results implicated that FAM83A and FAM83A-AS1 both played oncogenic roles in LUAD and FAM83A-AS1 could regulate the expression of FAM83A by sponging miR3p. +genetics_overexpression_promote 33732364 hsa-mir-375 Squamous Cell Carcinoma of Head and Neck Therefore, UASR1 is overexpressed in OSCC and regulates cancer cell proliferation by regulating the miR-375/JAK2 axis. +circulation_biomarker_diagnosis_ns 33732359 hsa-mir-130a differentiated thyroid gland carcinoma A novel exosomal miRNA, miR-130a-3p, was found to be significantly decreased in the serum of patients with DTC compared with those with benign thyroid tumors and healthy controls. +genetics_overexpression_promote 33732358 hsa-mir-101 Adenocarcinoma of Lung 3p overexpression sensitized LUAD cells to ionizing radiation by decreasing the abilities of LUAD cell proliferation, colony formation, DNA damage repair and increasing caspase-3 activity and apoptosis of LUAD cells following ionizing radiation. +other 33732346 hsa-mir-145 tongue squamous cell carcinoma MicroRNA-145-5p aggravates cell apoptosis and oxidative stress in tongue squamous cell carcinoma. +genetics_knock down_promote 33732340 hsa-mir-24 Retinoblastoma 3p was restored following the overexpression of NEAT1 in RB cells. +lncRNA target 33732332 hsa-mir-874 Polycystic Ovary Syndrome 3p was upregulated in PCOS and promoted testosterone-induced GC apoptosis by suppressing HDAC1-mediated p53 deacetylation. +other 33732332 hsa-mir-874 Myocardial Infarction MicroRNA (miR)3p is a newly identified miRNA that is involved in several pathological processes, including cancer, myocardial infarction, bone formation and erectile dysfunction. +other 33732332 hsa-mir-874 Erectile Dysfunction MicroRNA (miR)3p is a newly identified miRNA that is involved in several pathological processes, including cancer, myocardial infarction, bone formation and erectile dysfunction. +circulation_biomarker_diagnosis_ns 33732323 hsa-mir-1184 Neonatal Sepsis In conclusion, decreased levels of serum miR-1184 may be a potential diagnostic biomarker for NS. +lncRNA target 33732318 hsa-mir-106a Osteoarthritis Baicalein (BAI) and microRNA (miR)-106a-5p suppress the progression of OA; however, the effects of BAI and miR-106a-5p for the combined treatment of OA are not completely understood. In conclusion, the results of the present study revealed that the combination of BAI and miR-106a-5p mimic significantly decreased IL-1beta-induced inflammatory injury in CHON-001 cells, which may serve as a novel therapeutic strategy for OA. +lncRNA target 33732309 hsa-mir-22 Osteoporosis Previous studies have demonstrated that microRNA-22 (miR-22) is the negative modulator of osteogenesis that may target caveolin-3 (CAV3), which has been reported to enhance bone formation and inhibit the progression of osteoporosis as well as apoptosis. +transcription factor target 33732309 hsa-mir-22 Bone Diseases Collectively, these results indicate a novel molecular mechanism by which miR-22 contributes to DEX-induced osteoblast dysfunction and apoptosis via the miR-22/CAV3 pathway. +target gene 33732308 hsa-mir-769 Prostatic Neoplasms miR-769-5p is an oncogene targeting ARHGAP10, which in turn is a candidate tumor suppressor in prostate cancer. +genetics_knock down_promote 33732298 hsa-mir-424 Osteosarcoma Long non-coding RNA small nucleolar RNA host gene 1 knockdown suppresses the proliferation, migration and invasion of osteosarcoma cells by regulating microRNA-424-5p/FGF2 in vitro. +other 33732103 hsa-mir-30 Hypertension In conclusion, decreased miRNA3p might contribute to CI in hypertensive patients by decreasing frontal CVR and could be a biomarker of early diagnosis. +exosome 33732041 hsa-mir-192 Adenocarcinoma of Lung Dysregulation of exosomal miR-192 and miR-194 expression in lung adenocarcinoma patients. +circulation_biomarker_prognosis_ns 33732041 hsa-mir-194 Adenocarcinoma of Lung It was observed that the NSCLC participants who had high serum based miR-194 expression showed 22 months of overall median survival while low expression of serum based miR-194 expression showed 18 months of overall median survival. +genetics_knock down_promote 33732022 hsa-mir-942 Colorectal Neoplasms 5p mimic or BATF2 knockdown. +genetics_knock down_promote 33732021 hsa-mir-152 Carcinoma, Renal Cell 3p silencing or RAB14 addition abolished the inhibitory effects of HCG18 knockdown on ccRCC progression. +genetics_overexpression_promote 33732018 hsa-mir-129 Osteosarcoma 5p overexpression led to downregulated Lnc712. +other 33731830 hsa-mir-28 Lentivirus Infections 5p, and let-7b-3p, as well as increased beta-defensin 1 after SIV infection. +other 33731830 hsa-mir-28 Simian Acquired Immunodeficiency Syndrome 5p, and let-7b-3p, as well as increased beta-defensin 1 after SIV infection. +other 33731513 hsa-mir-665 Coronary Artery Disease The expression level of miR-665 was significantly downregulated in patients with CAD. +other 33731207 hsa-mir-490 Stomach Neoplasms Mechanistically, circFAM73A promoted GC malignancy by regulating miR3p/HMGA2 in a positive feedback loop and recruiting HNRNPK to facilitate beta-catenin stabilization. +transcription factor target 33731131 hsa-mir-20a Colorectal Neoplasms Additionally, based on the fact that SP1 promotes MACC1 transcription, we determined via immunoblotting that the oncogenic MACC1/MET signaling pathway was inactivated in the context of miR-320a-induced SP1 downregulation CONCLUSION: Taken together, our study is the first to describe a miR-320a/SP1 negative reciprocal interaction, which contributes to cell growth and invasion in CRC through modulation of the MACC1/MET signaling pathway. +lncRNA target 33730981 hsa-mir-103 Asthma In vivo, miR-103 inhibition weakened the alleviating effects of BA on asthma, which was then reversed after silencing of TLR4. We highlighted that BA has the potency to halt the pediatric asthma progression via miR-103 upregulation and the TLR4/NF-kappaB axis inhibition. +circulation_biomarker_diagnosis_ns 33730720 hsa-mir-130a Coronary Artery Disease CONCLUSION: Measurement of circulating proangiogenic miRNAs especially miR-let-7f, miR-19a, miR-126, miR-130a, and miR-378 helps predict MACCE risk in ULMCAD patients who underwent CABG. +circulation_biomarker_diagnosis_ns 33730720 hsa-mir-378 Coronary Artery Disease CONCLUSION: Measurement of circulating proangiogenic miRNAs especially miR-let-7f, miR-19a, miR-126, miR-130a, and miR-378 helps predict MACCE risk in ULMCAD patients who underwent CABG. +circulation_biomarker_diagnosis_ns 33730720 hsa-mir-19a Coronary Artery Disease CONCLUSION: Measurement of circulating proangiogenic miRNAs especially miR-let-7f, miR-19a, miR-126, miR-130a, and miR-378 helps predict MACCE risk in ULMCAD patients who underwent CABG. +circulation_biomarker_diagnosis_ns 33730720 hsa-mir-126 Coronary Artery Disease CONCLUSION: Measurement of circulating proangiogenic miRNAs especially miR-let-7f, miR-19a, miR-126, miR-130a, and miR-378 helps predict MACCE risk in ULMCAD patients who underwent CABG. +circulation_biomarker_diagnosis_ns 33730720 hsa-let-7f Coronary Artery Disease CONCLUSION: Measurement of circulating proangiogenic miRNAs especially miR-let-7f, miR-19a, miR-126, miR-130a, and miR-378 helps predict MACCE risk in ULMCAD patients who underwent CABG. +target gene 33730679 hsa-mir-181a Breast Neoplasms MicroRNA-181a suppresses norethisterone-promoted tumorigenesis of breast epithelial MCF10A cells through the PGRMC1/EGFR-PI3K/Akt/mTOR signaling pathway. +lncRNA target 33730297 hsa-mir-21 Lung Injury The APE rats were injected with adenovirus to evaluate the effect of Sp1, miR-21, or PTEN on lung injury and inflammation. In summary, Curcumin decreased miR-21 expression by downregulating Sp1 to upregulate PTEN and to impair the NF-kappaB signaling pathway, thus suppressing lung injury and inflammation in APE rats. +lncRNA target 33730297 hsa-mir-21 Pulmonary Embolism The APE rats were injected with adenovirus to evaluate the effect of Sp1, miR-21, or PTEN on lung injury and inflammation. In summary, Curcumin decreased miR-21 expression by downregulating Sp1 to upregulate PTEN and to impair the NF-kappaB signaling pathway, thus suppressing lung injury and inflammation in APE rats. +lncRNA target 33730072 hsa-mir-221 pancreatic adenocarcinoma Our results demonstrated that treatment of TNF-alpha lead to a decreased expression of tissue inhibitor of metalloproteinase- 3 (TIMP-3) protein and an induction of MMP-9 protein and cell invasion through an upregulation of microRNA-221 (miR-221) in human PDAC cells. +epigenetics 33729551 hsa-mir-124-2 Cervical Intraepithelial Neoplasia "This study evaluates the cumulative score of immunohistochemical expression of p16(ink4a) (Scores 0-3) and Ki-67 (Scores 0-3), referred to as the ""immunoscore"" (IS), in 262 CIN2 and 235 CIN3 lesions derived from five European cohorts in relation to immunohistochemical HPV E4 expression and FAM19A4/miR124-2 methylation in the corresponding cervical scrape." +transcription factor target 33729484 hsa-mir-92d Fibrosis, Renal Thus, the present study aimed to investigate the effect of miR-92d-3p on the progression of DN renal fibrosis. miR-92d-3p suppressed the progression of DN renal fibrosis by inhibiting the activation of the C3/HMGB1/TGF-beta1 pathway and EMT. +transcription factor target 33729484 hsa-mir-92d Diabetic Nephropathies Thus, the present study aimed to investigate the effect of miR-92d-3p on the progression of DN renal fibrosis. miR-92d-3p suppressed the progression of DN renal fibrosis by inhibiting the activation of the C3/HMGB1/TGF-beta1 pathway and EMT. +target gene 33729395 hsa-mir-146a Alzheimer Disease MicroRNA-146a inhibition promotes total neurite outgrowth and suppresses cell apoptosis, inflammation, and STAT1/MYC pathway in PC12 and cortical neuron cellular Alzheimer's disease models. +circRNA target 33729388 hsa-mir-33a Squamous Cell Carcinoma of Head and Neck In conclusion, hsa_circ_0002162 had an important role in malignant progression of TSCC through targeting miR-33a-5p. +circulation_biomarker_diagnosis_ns 33729026 hsa-mir-192 Liver Injury Observations from this study revealed that expression levels of miR-122 and miR-192 were significantly decreased in the serum of antitubercular drug induced liver injury patients only. +circulation_biomarker_diagnosis_ns 33729026 hsa-mir-192 Tuberculosis Observations from this study revealed that expression levels of miR-122 and miR-192 were significantly decreased in the serum of antitubercular drug induced liver injury patients only. +circulation_biomarker_diagnosis_ns 33729026 hsa-mir-122 Liver Injury Observations from this study revealed that expression levels of miR-122 and miR-192 were significantly decreased in the serum of antitubercular drug induced liver injury patients only. +circulation_biomarker_diagnosis_ns 33729026 hsa-mir-122 Tuberculosis Observations from this study revealed that expression levels of miR-122 and miR-192 were significantly decreased in the serum of antitubercular drug induced liver injury patients only. +other 33728810 hsa-mir-1236 Uterine Cervical Neoplasms In conclusion, our data indicated that circRNA_101996/miR3p/TRIM37 axis accelerated cervical cancer development, providing novel insights into cervical cancer diagnosis and treatment. +lncRNA target 33728802 hsa-mir-21 Lupus Erythematosus, Systemic These findings indicated that the rs145204276 ID/DD genotypes in the LncRNA-GAS5 gene promoter region may be protected against SLE by up-regulating the expression of LncRNA-GAS5, which consecutively regulated miR-21 and PTEN levels. +lncRNA target 33728753 hsa-mir-200b Breast Neoplasms In conclusion, nobiletin inhibited the tumorigenesis of BC via regulation of miR-200b/JAZF1 axis. +lncRNA target 33728585 hsa-mir-577 Carcinoma, Non-Small-Cell Lung Taken together, LINC00520 displayed its tumor-promotive roles through modulating the miR-577/CCNE2 axis, highlighting a potential therapeutic strategy for NSCLC patients. +transcription factor target 33728488 hsa-mir-21 Pancreatic Carcinoma miR5p targeted KLF3 to mediate the differentiation and activities of PaCa stem cells, and KLF3 was downregulated in PaCa stem cells. +other 33728345 hsa-mir-145 Adenomyosis The establishment of circPVT1/miR-145/Talin1 pathway might present a novel therapeutic insight for ADS. +lncRNA target 33728339 hsa-mir-145 Esophageal Neoplasms 5p could inhibit the expression of ABRACL, in turn inhibiting the proliferation, migration, and invasion of EC cells. +other 33727891 hsa-mir-5 Liver Cirrhosis The diagnosis model (miR-5) can distinguish significant and nonsignificant liver fibrosis with high sensitivity and specificity. +other 33727891 hsa-mir-5 Hepatitis B, Chronic The diagnosis model (miR-5) can distinguish significant and nonsignificant liver fibrosis with high sensitivity and specificity. +genetics_knock down_promote 33727831 hsa-mir-1248 Carcinoma, Non-Small-Cell Lung Similarly, CCND2 overexpression also reversed the suppressive effect of miR-1248 on NSCLC progression. +circulation_biomarker_diagnosis_up 33727052 hsa-mir-126 Retinopathy of Prematurity Together, these results showed that intravitreal injection of miR-126 plasmid could inhibit retinal neovascularization by down-regulating VEGFA expression, suggesting a potential therapeutic effect for ROP. +lncRNA target 33727043 hsa-mir-130a Breast Neoplasms CONCLUSION: This study provides evidence that HDAC3 increases HMGB3 expression to promote the immune escape of breast cancer cells via down-regulating miR-130a-3p. +lncRNA target 33726823 hsa-mir-135b Parkinson Disease Besides, the correlations between microRNA-135b-5p (miR-135b-5p) and MALAT1 or glycoprotein nonmetastatic melanoma protein B (GPNMB) in MPP(+)-stimulated cell model of PD were explored. CONCLUSION: Our findings reveal that MALAT1/miR-135b-5p/GPNMB axis regulated cell proliferation and apoptosis in MPP(+)-stimulated cell model of PD, providing a potential biomarker and therapeutic target for PD. +target gene 33726770 hsa-mir-744 Prostatic Neoplasms Long non-coding RNA LINC01116 acts as an oncogene in prostate cancer cells through regulation of miR-744-5p/UBE2L3 axis. +other 33725861 hsa-mir-21 Coronary Disease CONCLUSION: This study clarified confusions about the specificity and sensitivity of miRNA-21 on coronary restenosis after PCI, thus further guiding their promotion and application. +other 33725861 hsa-mir-21 Coronary Restenosis CONCLUSION: This study clarified confusions about the specificity and sensitivity of miRNA-21 on coronary restenosis after PCI, thus further guiding their promotion and application. +circulation_biomarker_diagnosis_ns 33725857 hsa-mir-145 Myocardial Infarction, Acute Secondary outcomes are plasma levels of microRNA-145, plasma cardiac enzyme, and Troponin I levels in blood samples, changes in ST-segment in ECG, Seattle Angina Questionnaire, the efficacy of angina symptoms, and occurrence of major adverse cardiac events. +circulation_biomarker_diagnosis_ns 33725857 hsa-mir-145 Reperfusion Injury Secondary outcomes are plasma levels of microRNA-145, plasma cardiac enzyme, and Troponin I levels in blood samples, changes in ST-segment in ECG, Seattle Angina Questionnaire, the efficacy of angina symptoms, and occurrence of major adverse cardiac events. +exosome 33725769 hsa-mir-125b-1 Atherosclerosis 3p was expressed in hMSCs-Ad exosomes and can promote T lymphocyte apoptosis and alleviate AS by down-regulating BCL11B expression. +lncRNA target 33725572 hsa-mir-4426 Uterine Cervical Neoplasms miR-4426 specifically binds circ0000069 and mediates its functions in CC development. In conclusion, circ0000069 was upregulated partially due to m6A modification, which promoted cell proliferation and migration via sponging miR-4426 in CC. +lncRNA target 33725330 hsa-mir-34b Colorectal Neoplasms Our data demonstrated the functions and mechanisms of ZFAS1 in CRC metastasis, illustrating miR-34b directly targets ZFAS1 and inhibits metastasis ability of CRC cells. +genetics_knock down_promote 33725277 hsa-mir-212 Femoral Neck Fractures CONCLUSIONS: These data suggest MALAT1 knockdown promoted the biological behavior of LPS-treated MG-63 cells via sponging miR-212, which may provide a new therapeutic avenue for delayed union of femoral neck fracture. +lncRNA target 33725258 hsa-mir-451b Stomach Neoplasms Also, upregulation of the KLF4 and SOX2 and downregulation of the CD44, OCT3/4, and NANOG decreased Self-renewal ability of gastric cancer stem cells under hsa-miR-451b inhibition. +genetics_knock down_suppress 33725240 hsa-mir-433 Esophageal Squamous Cell Carcinoma 3p performed anti-proliferative, anti-migratory, and anti-invasive abilities in ESCC cells, which were reversed by REV3L overexpression. +lncRNA target 33724979 hsa-mir-451 Thyroid Cancer, Papillary Our findings suggest that miR-451 may be a potential therapeutic target for PTC. +other 33724979 hsa-mir-451 Holoprosencephaly 7 miR-451 is expressed in human papillary thyroid carcinoma (PTC) tissues and is associated with tumor progression. +genetics_knock down_promote 33724862 hsa-mir-495 Melanoma 3p downregulation or HK2 upregulation partially reversed RNCR2 knockdown-induced inhibition of melanoma cell growth, EMT, and glycolysis. +other 33724726 hsa-mir-411 Coronary Artery Disease 3p might be potential markers for CR in CAD patients. +other 33724726 hsa-mir-142 Coronary Artery Disease 3p might be potential markers for CR in CAD patients. +other 33724726 hsa-mir-24 Coronary Artery Disease 3p might be potential markers for CR in CAD patients. +genetics_overexpression_promote 33724144 hsa-mir-487a Squamous Cell Carcinoma of Head and Neck Moreover, the mimicking of miR-487a-3p significantly reduces the OSCC cell growth and invasion, and PPM1A overexpression exerts oncogenic effects and hinders the anti-oncogenic effects of miR-487a-3p. +other 33723932 hsa-mir-21 Leukoplakia, Oral The results of qRT-PCR showed that the expression of hypoxia-inducible factor 1alpha, chemokine cc-motif ligand 2, and matrix metalloproteinase 3 mRNA and miR-21 in normal mucosa, OLK, and SCC increased in a stepwise manner. +lncRNA target 33723747 hsa-mir-25 Cardiomyopathies 3p enhances cardiac fibrosis by suppressing Dkk3 to activate Smad3 and fibrosis-related gene expression. +lncRNA target 33723252 hsa-mir-23b Carcinoma, Hepatocellular Taken together, our findings suggest that miR-23b-5p acted as a tumor suppressor role in HCC progression by targeting FOXM1 and may serve as a potential novel biomarker for HCC diagnosis and prognosis. +transcription factor target 33723242 hsa-mir-20a Arthritis, Rheumatoid In summary, we confirmed for the first time that PDX could effectively ameliorate CIA progression by restoring Treg/T(h)17 cell balance, which was mediated by inhibition of the NLRP3 inflammasome pathway via miR-20a. +genetics_knock down_promote 33723216 hsa-mir-127 Ischemia Accordingly, the overexpression of CISD1 effectively inhibited the autophagic cell death and physiological dysfunction in the brain of HI injury, whereas si-CISD1 reversed the neuroprotective effects of KO-miR +genetics_knock down_suppress 33722958 hsa-mir-217 Colorectal Neoplasms 3p reversed the effects of circ_0000338 knockdown on cell 5-FU resistance in CRC. +genetics_knock down_suppress 33722958 hsa-mir-485 Colorectal Neoplasms 3p reversed the effects of circ_0000338 knockdown on cell 5-FU resistance in CRC. +other 33722777 hsa-mir-6894 Stomach Neoplasms Circular RNA circAFF2 accelerates gastric cancer development by activating miR-6894-5p and regulating ANTXR 1 expression. +genetics_knock down_suppress 33722672 hsa-mir-103 Subarachnoid Hemorrhage 3p antagomir relieved Cav-1 loss, sequentially reduced BBB permeability and improved neurological function. +genetics_overexpression_promote 33722663 hsa-mir-499a Intervertebral Disc Degeneration CONCLUSION: Overexpressed XIST caused NPC degeneration through promoting apoptosis and extracellular matrix degradation of IL-1beta-treated NPCs through targeting miR-499a-5p, and therefore can serve as a potential treatment for IDD. +exosome 33722655 hsa-mir-19b-1 Urinary Bladder Neoplasms CONCLUSION: BMSCs-derived exosomal miR-19b +genetics_overexpression_promote 33722639 hsa-mir-485 Glioma 5p overexpression. +lncRNA target 33722502 hsa-mir-338 Carcinoma, Hepatocellular CONCLUSIONS: ST8SIA6-AS1 enhances the progression of HCC via miR +lncRNA target 33722298 hsa-mir-1290 Muscular Atrophy In addition, miR-1290 may be a potential therapeutic target for sarcopenia treatment. +lncRNA target 33722196 hsa-mir-105 Breast Neoplasms 3p acts as an oncogene to promote the proliferation and metastasis of breast cancer cells by targeting GOLIM4, which provides a new target for the prevention and treatment of breast cancer. +lncRNA target 33721916 hsa-mir-1277 Osteoarthritis HOTAIR aggravated chondrocyte apoptosis and inflammation in OA via regulating miR +genetics_overexpression_promote 33721459 hsa-mir-10a Carcinoma, Renal Cell In addition, low expression of miR-10a or overexpression of BDNF predicted poor prognosis of RCC patients. +lncRNA target 33721456 hsa-mir-877 Ovarian Neoplasms CONCLUSIONS: Our research elucidated that miR-877 played a role of tumor suppressor in OC by negatively regulating FOXM1 which may bring a novel insight into new molecular therapeutic targets and biomarkers for OC. +genetics_overexpression_promote 33721450 hsa-mir-125 Melanoma Next, malignant melanoma A375 cells were selected to exogenously overexpress miR-125 (miR-125 mimic group). +lncRNA target 33721450 hsa-mir-125b Melanoma CONCLUSIONS: MiR-125b acts as a tumor suppressor in MM cells by targeting and binding to NCAM. +genetics_overexpression_promote 33721449 hsa-mir-137 Uveal melanoma MiR-137 overexpression evidently suppressed UM cell proliferation, invasion and migration. +lncRNA target 33721442 hsa-mir-185 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: LSINCT5 is abnormally upregulated in OSCC specimens and drives its malignant progression through the miR +other 33721432 hsa-mir-573 Carcinoma, Non-Small-Cell Lung In qRT-PCR, the miR-573 expression in lung cancer tissues obviously declined, which was significantly negatively correlated with the expression of CLK2. CONCLUSIONS: Highly-expressed CLK2 significantly enhances the proliferation of lung cancer cells, thereby promoting the occurrence and development of lung cancer, which may be regulated by miR-573. +genetics_overexpression_promote 33721156 hsa-mir-9 Hyperglycemia MiR-9 significantly inhibited NICD1 mRNA expression and alleviated hyperglycemia-induced injury of the NICD1-overexpressing cells. +genetics_overexpression_promote 33720323 hsa-mir-34b Urinary Bladder Neoplasms However, the promoting effects of CAF-Exo on BC cell resistance to cisplatin were abolished by miR-34b-5p overexpression and ABCB1 silencing. +circulation_biomarker_diagnosis_ns 33719810 hsa-mir-214 Hodgkin Disease 3p were significantly higher in the blood samples of RPL patients than in control samples. +lncRNA target 33719773 hsa-mir-155 Bronchopneumonia CONCLUSION: NEAT1 silencing suppressed LPS-induced BEAS-2B cells injury and inflammation by the mediation of miR5p/MyD88/NF-kappaB axis. +circulation_biomarker_diagnosis_up 33719498 hsa-mir-4286 Acute Coronary Syndrome The upregulated miR-4286 in plasma can be attributed to higher triglyceride level and may mediate the effect of triglyceride on incident ACS. +transcription factor target 33719400 hsa-mir-135a Schizophrenia As a proof-of-concept, in MKinduced schizophrenia model, we found that astrocytes, instead of neurons, are more heterogeneously affected in the hippocampus of rats that underwent repeated injection of MK-801, showing an expression fingerprint related to differentially down-regulated miRNA-135a and miRNA-143; the associated astrocyte subpopulation is also more spatially dispersed in the hippocampus, suggesting an astrocyte dysregulation in the induced schizophrenia animals. +other 33719338 hsa-mir-7850 Carcinoma, Hepatocellular 5p. +other 33719338 hsa-mir-139 Carcinoma, Hepatocellular 5p. +other 33719338 hsa-mir-122 Carcinoma, Hepatocellular 5p. +circulation_biomarker_diagnosis_ns 33719338 hsa-mir-92b Carcinoma, Hepatocellular Hsa_circ_0077210/hsa-miR-92b-3p/cytoplasmic polyadenylation element binding protein-3 (CPEB3) and acyl-Coenzyme A dehydrogenase, long chain (ACADL) were validated in HCC tissue. +lncRNA target 33719273 hsa-mir-191 Prostatic Neoplasms Conclusion: miRNA-191 promote the proliferation, migration and invasion of prostate cancer PC-3 cells by targeting PLCD1. +lncRNA target 33719270 hsa-mir-218 Lung Neoplasms Conclusion: lncRNA UNC5B-AS1 promotes adhesion, invasion and migration of lung cancer cells through targeted regulation of miR +genetics_overexpression_promote 33719266 hsa-mir-203a Breast Neoplasms Conclusion: The overexpression of mir-203a in the early stage of breast cancer may inhibit the expression of its target gene ATM, which may be a protective mechanism to regulate the proliferation,metastasis and invasiveness of tumor cells. +genetics_overexpression_promote 33719246 hsa-mir-27a Femur Head Necrosis OBJECTIVE: To investigate whether exosomes derived from miR-27a-overexpressing human umbilical vein endothelial cells (HUVECs)-exo (miR-27a) can promote bone regeneration and improve glucocorticoids (GC) induced osteonecrosis of femoral head (ONFH) (GC-ONFH). +target gene 33718760 hsa-mir-340 Ovarian Neoplasms The LGR5, FOXO1, and miR-340 genes can be targeted for early diagnosis and more accurate treatment of ovarian cancer and may prevent some of the ovarian cancer complications such as infertility. +lncRNA target 33718673 hsa-mir-34 Endometriosis These results imply that miR-34a might regulate p53 through SIRT-1 and subsequently FoxO-1 expression in endometriotic tissue, and so it can contribute to the pathogenesis of endometriosis by decreasing the naturally occurring apoptosis in endometrium. +lncRNA target 33718673 hsa-mir-34a Endometriosis These results imply that miR-34a might regulate p53 through SIRT-1 and subsequently FoxO-1 expression in endometriotic tissue, and so it can contribute to the pathogenesis of endometriosis by decreasing the naturally occurring apoptosis in endometrium. +exosome 33718666 hsa-mir-1 Diabetes Mellitus CONCLUSION: Engineered miR-31 exosomes are an ideal disease pathophysiology-initiated RNAi therapeutic agent for diabetic wounds. +exosome 33718596 hsa-mir-155 Colonic Neoplasms M2 macrophage-derived exosomal microRNA-155-5p promotes the immune escape of colon cancer by downregulating ZC3H12B. +lncRNA target 33718536 hsa-mir-132 Stress Disorders, Post-Traumatic In the present study, we explored the possible molecular mechanism of miR-132, focusing on the involvement of MeCP2 and BDNF in the formation of anxiety-like symptoms of PTSD. Our results suggest that miR-132 might be involved in the formation of anxiety-like symptoms of adult rat PTSD models by targeting MeCP2, and this effect is related to BDNF/TrkB and its downstream ERK and Akt signaling pathways. +lncRNA target 33718536 hsa-mir-132 Anxiety Disorders Our results suggest that miR-132 might be involved in the formation of anxiety-like symptoms of adult rat PTSD models by targeting MeCP2, and this effect is related to BDNF/TrkB and its downstream ERK and Akt signaling pathways. +genetics_overexpression_promote 33718512 hsa-mir-1254 Nasopharyngeal Carcinoma overexpressing NPC cells. +target gene 33718387 hsa-mir-206 Prostatic Neoplasms Circular RNA circ_0057558 Controls Prostate Cancer Cell Proliferation Through Regulating miR-206/USP33/c-Myc Axis. +target gene 33718221 hsa-mir-1 Colorectal Neoplasms MiR-1-3p Suppresses Colorectal Cancer Cell Proliferation and Metastasis by Inhibiting YWHAZ-Mediated Epithelial-Mesenchymal Transition. +other 33718187 hsa-mir-1307 Kahrizi Syndrome 5p/IGF2BP3) that could serve a critical role for potential clinical application in KIRC patients. +other 33718187 hsa-mir-204 Kahrizi Syndrome 5p/IGF2BP3) that could serve a critical role for potential clinical application in KIRC patients. +target gene 33718138 hsa-mir-20a Carcinoma, Ovarian Epithelial MicroRNA-320a Promotes Epithelial Ovarian Cancer Cell Proliferation and Invasion by Targeting RASSF8. +genetics_GWAS 33718136 hsa-mir-193a Stomach Neoplasms Epigenetic Silencing of STAT3-Targeted miR-193a, by Constitutive Activation of JAK/STAT Signaling, Leads to Tumor Progression Through Overexpression of YWHAZ in Gastric Cancer. +lncRNA target 33718133 hsa-mir-22 Carcinoma, Hepatocellular CONCLUSION: Inhibition of HDAC2 expression promotes histone acetylation in the MIR22HG promoter region, thereby up-regulating the expression of MIR22HG and promoting the production of miR5p, and ultimately increasing the sensitivity of liver cancer radiotherapy. +genetics_overexpression_promote 33718112 hsa-mir-137 Glioblastoma Overexpression of miR-137 inhibited cell invasion and enhanced cell chemosensitivity to temozolomide (TMZ) by directly targeting low-density lipoprotein receptor-related protein 6 (LRP6) in GBM. +lncRNA target 33718067 hsa-mir-485 Prostatic Hyperplasia DIO3OS facilitates BPH-1 cells EMT and WPMY-1 cells proliferation by upregulating CTGF and ZEB1 via miR +lncRNA target 33718067 hsa-mir-656 Prostatic Hyperplasia DIO3OS facilitates BPH-1 cells EMT and WPMY-1 cells proliferation by upregulating CTGF and ZEB1 via miR +other 33717654 hsa-mir-92a Fractures, Bone Upregulation of miRNA-92a-3p may therefore be a promising therapeutic strategy for promoting fracture healing and preventing nonunion. +other 33717654 hsa-mir-92a Brain Injuries, Traumatic Upregulation of miRNA-92a-3p may therefore be a promising therapeutic strategy for promoting fracture healing and preventing nonunion. +exosome 33717653 hsa-mir-188 Parkinson Disease 3p-enriched exosomes. +other 33717647 hsa-mir-146a Diabetic Nephropathies Our study unveils a novel role for miR-146a in ischemic heart disease. +genetics_GWAS 33717269 hsa-mir-29a Uterine Cervical Neoplasms The results demonstrated that miR-29a expression was downregulated in cervical cancer tissues and cells, and negatively correlated with p16 promoter hypermethylation. Taken together, the results of the present study demonstrated the epigenetic regulation of tumor suppressor p16 by miR-29a as a unique mechanism, thus providing a rationale for the development of miRNA-based strategies in the treatment of cervical cancer. +target gene 33717268 hsa-mir-124 Breast Neoplasms MicroRNA-124 suppresses the invasion and proliferation of breast cancer cells by targeting TFAP4. +target gene 33717260 hsa-mir-136 Head and Neck Neoplasms The miR-136-5p/ROCK1 axis suppresses invasion and migration, and enhances cisplatin sensitivity in head and neck cancer cells. +target gene 33717250 hsa-mir-4492 Ovarian Neoplasms Long non-coding RNA FOXD2-AS1 promotes proliferation, migration and invasion of ovarian cancer cells via regulating the expression of miR-4492. +lncRNA target 33717244 hsa-mir-432 Colorectal Neoplasms 5p can inhibit the migration and invasion of CRC cells by targeting CXCL5. +other 33717243 hsa-mir-183 Plaque, Atherosclerotic In the present study, miR-183 showed upregulated expression in atheromatous plaques and in bone marrow-derived macrophages (BMDMs) subjected to stimulation with oxidized low-density lipoproteins. +lncRNA target 33717243 hsa-mir-183 Cardiomegaly MicroRNA (miR)-183 is a small non-coding RNA that acts as a novel tumor suppressor and has recently been proposed to affect cardiac hypertrophy. +other 33717239 hsa-mir-146b Psoriasis miR-146b correlates with increased disease activity and psoriatic tissue inflammation and promotes keratinocyte proliferation in psoriasis. +lncRNA target 33717068 hsa-mir-148b Stomach Neoplasms CONCLUSIONS: Targeting miR-148b-5p inhibits immunity microenvironment and gastric cancer progression. +lncRNA target 33716779 hsa-mir-130a Acute Kidney Injury Taken together, our findings indicated that LncRNA H19 and miR-130a might represent novel therapeutic targets and early diagnostic biomarkers for the treatment of AKI. +other 33716639 hsa-mir-101 Alzheimer Disease We hypothesized that quercetin-conjugated superparamagnetic iron oxide nanoparticles (QT-SPIONs) have a better neuroprotective effect on AD than free quercetin and regulates the antioxidant, apoptotic, and APP gene, and miRNA-101. The increase in expression levels of APP gene and the decrease in mir101 led to the development of AD symptoms in rats treated with AlCl(3) while these results were reversed in the AlCl(3) QT-SPIONs group. +lncRNA target 33716239 hsa-mir-335 Thyroid Cancer, Papillary However, downregulating miR-335 diminished the effects of circ-PRKCI role on cell growth, metastasis and glycolysis in PTC cells; besides, there was a counteractive effect between miR-335 upregulation and E2F3 upregulation in PTC cells as well. Collectively, circ-PRKCI exerted oncogenic role in PTC by antagonizing cell progression and glycolysis via regulating miR-335/E2F3 axis, suggesting circ-PRKCI was a potential biomarker and target for PTC. +other 33715884 hsa-mir-146a Alzheimer Disease However, recent studies have shown that miR-146a-5p may also be involved in the development of Alzheimer disease (AD). +genetics_knock down_promote 33715625 hsa-mir-96 Squamous Cell Carcinoma of Head and Neck 5p overexpression could reverse the inhibitory effect of circ-KIAA0907 on OSCC progression, and UNC13C knockdown also could overturn the suppressive effect of miR +lncRNA target 33715582 hsa-mir-145 Lymphoma, Large B-Cell, Diffuse 5p regulated DLBCL cell growth and movement through suppressing S1PR1/STAT3/AKT pathway. +lncRNA target 33715222 hsa-mir-497b Reperfusion Injury The expression of miR-497b-5p was increased in liver I/R injury. miR-497b-5p could activate the nuclear factor kappa-B (NF-kappaB) pathway by inhibiting the MED1/TIMP-2 axis to promote liver I/R injury. +other 33715222 hsa-mir-497 Reperfusion Injury 5p in liver I/R injury were predicted by bioinformatics analysis. +transcription factor target 33715213 hsa-mir-342 Trichosporonosis Moreover, our data suggest that miR3p can indirectly promote inflammatory responses and may be a potential therapeutic target against trichosporonosis. +other 33715208 hsa-mir-191 Macular Degeneration Our findings suggest an anti-inflammatory effect of miR5p in Abeta(1-40) -induced RPE impairment, shedding light on novel preventive or therapeutic approaches for AMD-associated RPE impairment. +transcription factor target 33714953 hsa-mir-125a Esophageal Neoplasms These data indicate that miR-20b-5p and miR-125a-5p promote tumorigenesis in radioresistant KYSE-150R cells and have the potential to be used as novel therapeutic targets for the treatment of esophageal cancer. +transcription factor target 33714953 hsa-mir-20b Esophageal Neoplasms These data indicate that miR-20b-5p and miR-125a-5p promote tumorigenesis in radioresistant KYSE-150R cells and have the potential to be used as novel therapeutic targets for the treatment of esophageal cancer. +other 33714676 hsa-mir-340 Lung Neoplasms CONCLUSION miR-340 was downregulated, whereas CCND1 was upregulated in LC tissues, and the expression levels of the two genes were closely related to the prognosis and clinicopathological characteristics of LC. +genetics_overexpression_promote 33714261 hsa-mir-424 Carcinoma, Hepatocellular Functionally, overexpressing miR +lncRNA target 33714208 hsa-mir-523 Squamous Cell Carcinoma of Head and Neck In summary, our results demonstrated that LINC01638/miR5p/BATF3 axis plays a crucial function in initiating LSCC development and may be a potential target for tumor therapy. +other 33714199 hsa-mir-429 Stomach Neoplasms Moreover, linc00641 sponged the expression of miR-429 and subsequently upregulated Notch-1 expression in gastric cancer cells. We concluded that linc00641 promoted the malignant progression of gastric cancer by modulating the miR-429/Notch-1 axis. +transcription factor target 33714198 hsa-mir-95 Stomach Neoplasms 3p helped develop DDP-resistance through down-regulation of EMP1 and increasing phosphorylation of the PI3K/Akt pathway in GC. +genetics_overexpression_promote 33713752 hsa-mir-21 Pneumococcal Infections Functionally, we found that miR-21 overexpression induced the NF-kappaB pathway along with inflammation in cells exposed to PCV2. +genetics_overexpression_promote 33713752 hsa-mir-21 Inflammation Further, the overexpression of PDCD4 or circPDCD4 downregulated miR-21 levels and subsequently, attenuated the miR +lncRNA target 33713655 hsa-mir-706 Subarachnoid Hemorrhage Further experiments confirmed that miR-706 could alleviate white matter injury and improve neurological behavior, at least partially by inhibiting the PKCalpha/MST1/NF-kappaB pathway and the release of inflammatory cytokines. +lncRNA target 33713655 hsa-mir-706 Leukoencephalopathies Further experiments confirmed that miR-706 could alleviate white matter injury and improve neurological behavior, at least partially by inhibiting the PKCalpha/MST1/NF-kappaB pathway and the release of inflammatory cytokines. +genetics_overexpression_promote 33713570 hsa-mir-874 Short Stature, Idiopathic, Autosomal 3p overexpression antagonized the suppression of endochondral ossification, hypertrophy and chondrocyte growth caused by circANAPC2 overexpression. +other 33713567 hsa-mir-29c Heart Neoplasms We identified miRNAs that may serve as potential predictors for the subsequent development of ACR: hsa-miR-29c-3p (ACR) and hsa-miR5p (AMR). +circulation_biomarker_diagnosis_ns 33713567 hsa-mir-151a Heart Neoplasms We found three miRNAs with significantly increased serum levels in patients with biopsy-proven cardiac rejection when compared with patients without rejection: hsa-miR +circulation_biomarker_diagnosis_ns 33713567 hsa-mir-139 Heart Neoplasms We found three miRNAs with significantly increased serum levels in patients with biopsy-proven cardiac rejection when compared with patients without rejection: hsa-miR +circulation_biomarker_diagnosis_ns 33713567 hsa-mir-186 Heart Neoplasms We found three miRNAs with significantly increased serum levels in patients with biopsy-proven cardiac rejection when compared with patients without rejection: hsa-miR +other 33713567 hsa-mir-486 Heart Neoplasms Overall, hsa-miR5p was most strongly associated with acute rejection episodes. +other 33713393 hsa-mir-34a Neurotoxicity Syndromes The (ENSMUST00000137546, ENSMUST00000160950)/ (miRNA-34a-5p, miR-130a-3p) / mRNAs (e.g., Il12b, Irf1) interaction network may functions in perinatal glyphosate exposure-induced neurotoxicity. +other 33713393 hsa-mir-130a Neurotoxicity Syndromes The (ENSMUST00000137546, ENSMUST00000160950)/ (miRNA-34a-5p, miR-130a-3p) / mRNAs (e.g., Il12b, Irf1) interaction network may functions in perinatal glyphosate exposure-induced neurotoxicity. +other 33713356 hsa-mir-122 Equine Hepacivirus Infections EqHV, as HCV, is stimulated by direct binding of the liver-specific microRNA (miR), miR-122. Interestingly, we found that EqHV infection sequesters enough miR-122 to functionally affect gene regulation in the liver. +lncRNA target 33712887 hsa-mir-506 Glioma Our studies identified that LINC01410 accelerates the progression of glioma through acting as a ceRNA for miR3p and elevating NOTCH2 expression to further activate the Notch signaling pathway, which indicated that LINC01410 might act as a novel regulator of glioma progression. +circulation_biomarker_diagnosis_ns 33712363 hsa-mir-152 Instent Restenosis The aim of present study is to investigate the potential early-stage diagnostic role of miR-152 and miR-148a expression levels for ISR in peripheral blood mononuclear cells (PBMCs) of patients who underwent stent implantation. +lncRNA target 33711383 hsa-mir-340 Adenocarcinoma of Lung 3p inhibits HUS1 expression, which was higher expressed in LUAD tissues and promoted the proliferation and migration ability of LUAD cells. +circulation_biomarker_prognosis_ns 33711036 hsa-mir-107 Carcinoma, Hepatocellular Furthermore, we describe a potential role of circulating miR-107 levels as a diagnostic biomarker in patients with early-stage HCC. +other 33710774 hsa-mir-646 Hypertrophy, Right Ventricular The expression of circRNA-0068481, miR-646 and miR-570 showed a considerable capability to diagnose RVH in PAH patients. +other 33710774 hsa-mir-646 Hypertension, Pulmonary The expression of circRNA-0068481, miR-646 and miR-570 showed a considerable capability to diagnose RVH in PAH patients. +lncRNA target 33710685 hsa-mir-23a Diabetes Mellitus, Type 2 Integrative analyses of APC miRNome and transcriptome from FDRs revealed down-regulated hsa-miR-23a-5p, -193a-5p and -193b-5p accompanied by up-regulated Insulin-like Growth Factor 2 (IGF2) gene which proved to be their direct target. +genetics_overexpression_suppress 33710684 hsa-mir-148a Ovarian Neoplasms Further rescue experiments revealed that downregulation of miR-148a-3p and overexpression of AKT2 obviously diminished the effects of HOTTIP downregulation in OC cells. +lncRNA target 33710445 hsa-let-7f Periodontitis Circ_0085289 and SOCS6 levels were reduced, and let-7f-5p level was increased in periodontitis patients and LPS-treated PDLCs. Circ_0085289 alleviated PDLC injury induced by LPS stimulation via modulating let-7f-5p/SOCS6 axis, suggesting a promising biomarker for periodontitis treatment. +lncRNA target 33710444 hsa-mir-1 Sepsis In a word, this study indicates that NEAT1 inhibits the LPS-induced progression of sepsis in RAW264.7 cells by modulating miR5p/POU2F1 axis, suggesting that NEAT1 will be the potential therapeutic target for sepsis. +exosome 33710183 hsa-mir-18a Breast Neoplasms The results showed that exosomes were relevant to the invasion and metastasis of breast cancer cells and hsa-miR-18a-3p might have the potential to become a new biomarker for distinguishing breast cancer from breast fibroma (AUC = 0.83, P value = 0.019). +other 33710119 hsa-mir-223 Anemia There was no difference in the miR-210, miR-122, and miR-223 levels between the IDA and control groups. The correlation between miR-223, a platelet function regulator, and the MCF index, suggested that miR-223 has a role in the development of hypercoagulability in IDA. +other 33710119 hsa-mir-210 Anemia In IDA, there is a close relationship between the severity of anemia and miR-210, and miR-210 expression is slightly increased in those with severe anemia. +other 33710119 hsa-mir-210 Anemia, Iron-Deficiency In IDA, there is a close relationship between the severity of anemia and miR-210, and miR-210 expression is slightly increased in those with severe anemia. +other 33710119 hsa-mir-223 Anemia, Iron-Deficiency There was no difference in the miR-210, miR-122, and miR-223 levels between the IDA and control groups. The correlation between miR-223, a platelet function regulator, and the MCF index, suggested that miR-223 has a role in the development of hypercoagulability in IDA. +other 33709519 hsa-mir-24 Colonic Neoplasms In this study, we aimed to investigate the effect of rs67085638 on the expression of CCAT1/miR3p/FSCN1 and the response of colon cancer to the treatment of PTX. +circRNA target 33709381 hsa-mir-1238 Carcinoma, Squamous Cell, Cutaneous 3p/FOXG1 axis in CSCC development, providing a target for CSCC therapy. +lncRNA target 33709299 hsa-mir-143 Reperfusion Injury, Cerebral Ischemia 3p protected against cerebral I/R injury through targeting FSTL1. +other 33709000 hsa-mir-126 Diabetes Mellitus Since levels of miR-126 have been found downregulated in diabetes, this study is aimed at investigating whether hyperglycemia affects expression of miR-126 in a retinal pigment epithelium cell line. +other 33709000 hsa-mir-126 Hyperglycemia In conclusion, our data support a role of miR-126 mimic-approach in counteracting proangiogenic effects of hyperglycemia. +other 33709000 hsa-mir-126 Duane Retraction Syndrome These results indicate that reduced levels of miR-126 may contribute to DR progression by increasing expression of VEGF-A in RPE cells. +lncRNA target 33708967 hsa-mir-150 Cardiomegaly CONCLUSIONS: Aerobic exercise improved cardiac function through inhibition of the lncRNA MALAT1 in CHF, and the potential mechanisms may be mediated via the miR +other 33708859 hsa-mir-4729 Hemorrhoids It was subsequently found that the level of miR-4729 expression was significantly decreased in hemorrhoid tissues. CONCLUSIONS: Our findings confirmed that the down-regulation of miR-4729 in hemorrhoid vascular endothelial cells was one of the main reasons for vascular proliferation. +transcription factor target 33708803 hsa-mir-455 Constriction, Pathologic This indicated that miR-455 is a novel target that would help improve treatment outcomes in patients suffering from vascular stenosis. +other 33708621 hsa-mir-139 Carcinoma, Hepatocellular 5p to promote YTHDF1 expression. +lncRNA target 33708473 hsa-mir-155 Atherosclerosis Therefore, to further explore the regulatory effect of miR-155 on neointima formation in AS and locate potential anti-atherosclerosis target. +target gene 33708462 hsa-mir-1225 Colorectal Neoplasms Post-transcriptional suppression of G protein-coupled receptor 15 (GPR15) by microRNA-1225 inhibits proliferation, migration, and invasion of human colorectal cancer cells. +lncRNA target 33708438 hsa-mir-370 Spinal Cord Injuries 3p mitigated spinal neuron apoptosis in an in vitro model of SCI. +target gene 33708430 hsa-mir-27b Stomach Neoplasms Combined targeting of vascular endothelial growth factor C (VEGFC) and P65 using miR-27b-3p agomir and lipoteichoic acid in the treatment of gastric cancer. +genetics_GWAS 33708425 hsa-mir-4477b Colorectal Neoplasms CONCLUSIONS: The mutation of the has-mir-4477b gene likely leads to the occurrence of adenoma and CRC. The has-mir-4477b gene may represent a key gene mutation in colorectal carcinogenesis and a multiyear cancer risk for patients that requires further attention. +exosome 33708424 hsa-mir-222 Colonic Neoplasms Exosomal miR-30a and miR-222 derived from colon cancer mesenchymal stem cells promote the tumorigenicity of colon cancer through targeting MIA3. +lncRNA target 33708421 hsa-mir-24 Esophageal Neoplasms Through survival analysis, we finally screened out two lncRNAs (DLEU2, RP11-890B15.3), three miRNAs (miR-26b-3p, miR-92a-3p, miR5p), and one mRNA (SIK2) as crucial prognostic factors for ESCA. +lncRNA target 33708421 hsa-mir-26b Esophageal Neoplasms Through survival analysis, we finally screened out two lncRNAs (DLEU2, RP11-890B15.3), three miRNAs (miR-26b-3p, miR-92a-3p, miR5p), and one mRNA (SIK2) as crucial prognostic factors for ESCA. +lncRNA target 33708421 hsa-mir-92a Esophageal Neoplasms Through survival analysis, we finally screened out two lncRNAs (DLEU2, RP11-890B15.3), three miRNAs (miR-26b-3p, miR-92a-3p, miR5p), and one mRNA (SIK2) as crucial prognostic factors for ESCA. +genetics_GWAS 33708240 hsa-mir-137 Schizophrenia Conclusion: The polymorphisms within the MIR137 gene are associated with susceptibility to schizophrenia, and a female-specific association of MIR137 with schizophrenia was reported in a Han Chinese population. +lncRNA target 33707625 hsa-mir-582 Multiple Myeloma Overall, our data demonstrated that RP11-301G19.1 is involved in MM cell proliferation by sponging miR5p and may serve as a therapeutic target for MM. +other 33707464 hsa-mir-199a Arthritis, Rheumatoid PTGS2 mRNA expression in RA patients' MCs correlated inversely with miRNA-199a-3p expression, which down-regulated PTGS2. +other 33707464 hsa-mir-199a Osteoarthritis PTGS2 mRNA expression in RA patients' MCs correlated inversely with miRNA-199a-3p expression, which down-regulated PTGS2. +lncRNA target 33707417 hsa-mir-4756 Carcinoma, Hepatocellular miR-4756 inhibition reversed the effects induced by circUBAP2 silencing on the IL-17 and IL-1beta levels and HCC cell migration. +lncRNA target 33706708 hsa-mir-34a Thyroid Cancer, Papillary Collectively, CASC7 inhibited the proliferation and migration of PTC cells by sponging miR-34a-5p to upregulate TP73 expression. +genetics_knock down_promote 33706585 hsa-mir-129 Thyroid Cancer, Papillary Knockdown of PITPNA-AS1 could significantly inhibit papillary thyroid cancer cell growth and migration and promote cell apoptosis while UNC5B overexpression plasmids or miR +transcription factor target 33706104 hsa-mir-28 Adenocarcinoma of Lung 3p targeting to PYCR1 suppressed the malignancy of LA cells by impeding cell proliferation and migration, while effectively promoting cell apoptosis. +other 33705918 hsa-mir-214 Inflammatory Bowel Diseases CONCLUSION: Our results suggested that Rh2 exhibits potential application value in the treatment of UC, and its mechanism is related to the downregulation of STAT3/miR-214 levels, which is expected to be applicable in the treatment of clinical UC. +genetics_overexpression_promote 33705864 hsa-mir-122 Hepatitis B Here we reported a robust HBV/HCV coinfection cell culture model by overexpressing human sodium-taurocholate cotransporting polypeptide (NTCP), CD81 and Mir122 into HepG2 cells and investigated interactions between HBV and HCV. +other 33705566 hsa-mir-200c Endometrial Neoplasms A distinct panel of miR-200a, miR-200b, miR-200c, miR-205, and miR-182 showed an area under the curve of 0.958, sensitivity 92%, specificity 89%, positive predictive value of 89% (95% CI 82%-94%) and negative predictive value of 91% (95% CI 85%-96%) in diagnosing endometrial cancer. +other 33705566 hsa-mir-200b Endometrial Neoplasms A distinct panel of miR-200a, miR-200b, miR-200c, miR-205, and miR-182 showed an area under the curve of 0.958, sensitivity 92%, specificity 89%, positive predictive value of 89% (95% CI 82%-94%) and negative predictive value of 91% (95% CI 85%-96%) in diagnosing endometrial cancer. +other 33705566 hsa-mir-205 Endometrial Neoplasms A distinct panel of miR-200a, miR-200b, miR-200c, miR-205, and miR-182 showed an area under the curve of 0.958, sensitivity 92%, specificity 89%, positive predictive value of 89% (95% CI 82%-94%) and negative predictive value of 91% (95% CI 85%-96%) in diagnosing endometrial cancer. +other 33705566 hsa-mir-200a Endometrial Neoplasms A distinct panel of miR-200a, miR-200b, miR-200c, miR-205, and miR-182 showed an area under the curve of 0.958, sensitivity 92%, specificity 89%, positive predictive value of 89% (95% CI 82%-94%) and negative predictive value of 91% (95% CI 85%-96%) in diagnosing endometrial cancer. +other 33705566 hsa-mir-182 Endometrial Neoplasms High miR-182 expression levels were significantly related to high-grade endometrioid tumors compared with low-grade tumors. +genetics_overexpression_promote 33704879 hsa-mir-142 Prostatic Neoplasms 5p) mimic and small-interfering RNA targeting cyclin D1 (CCND1, si-CCND1) could attenuate the inhibitory effects of ADAMTS9-AS1 overexpression on PCa cell growth. +other 33704509 hsa-mir-449a Pulmonary Disease, Chronic Obstructive Similar alterations in miR-449a have been reported in smokers with COPD. +lncRNA target 33703976 hsa-let-7 Cataract, Age-Related Moreover, CSB interacted with VCP, and let-7 c-5p induced dysregulation of autophagy by targeting ERCC6.Conclusion: In ARC, Let-7 c-5p-mediated downregulation of ERCC6 might prevent the degradation of autophagic vacuoles. +other 33694332 hsa-mir-210 Brain Ischemia Collectively, these results provide new molecular insight into the regulation of cell signalling during ischaemic injury, and suggest a novel mechanism whereby AMPK regulates miR3p to control p70S6K activity in ischaemic stroke and excitotoxic injury. +other 33694224 hsa-mir-126 Pre-Eclampsia OBJECTIVE: To investigate the expression of microRNA-126 (miR-126) and vascular endothelial cell adhesion molecule-1 (VCAM-1) in the placental tissues of women with early-onset preeclampsia (EOPE) and their effects on trophoblast invasion. CONCLUSION: There was a negative correlation between the expression of miR-126 and VCAM-1 in EOPE.MiR-126 and VCAM-1 may participate in the occurrence and development of EOPE by affecting the invasion ability of trophoblast cells. +other 33694209 hsa-mir-155 Alzheimer Disease Recent studies implicate miR-155, a miRNA known to regulate inflammatory responses, in the pathogenesis of neurodegenerative disorders including multiple sclerosis, ALS, familial Parkinson's disease, and AD. +other 33694209 hsa-mir-155 Amyotrophic Lateral Sclerosis Recent studies implicate miR-155, a miRNA known to regulate inflammatory responses, in the pathogenesis of neurodegenerative disorders including multiple sclerosis, ALS, familial Parkinson's disease, and AD. +other 33694209 hsa-mir-155 Multiple Sclerosis Recent studies implicate miR-155, a miRNA known to regulate inflammatory responses, in the pathogenesis of neurodegenerative disorders including multiple sclerosis, ALS, familial Parkinson's disease, and AD. +other 33694209 hsa-mir-155 Parkinson Disease, Familial, Type 1 Recent studies implicate miR-155, a miRNA known to regulate inflammatory responses, in the pathogenesis of neurodegenerative disorders including multiple sclerosis, ALS, familial Parkinson's disease, and AD. +other 33694209 hsa-mir-155 Neurodegenerative Diseases Recent studies implicate miR-155, a miRNA known to regulate inflammatory responses, in the pathogenesis of neurodegenerative disorders including multiple sclerosis, ALS, familial Parkinson's disease, and AD. +other 33694202 hsa-mir-221 Diminished Ovarian Reserve 3p expression promotes apoptosis of granulosa cells by upregulating FOXO1 expression, thus serving an important role in DOR pathogenesis. +virus_miRNA 33694159 ebv-mir-BART8 Nasopharyngeal Carcinoma EBV-miR-BART8-3p drives radioresistance-associated metastasis in nasopharyngeal carcinoma +lncRNA target 33694060 hsa-mir-1273g Glioma Overall, the results of our present study demonstrated that RP11-279C4.1 functions as an oncogene that promotes tumour progression by modulating the miR-1273g-3p/CBX3 axis in glioma, suggesting that RP11-279C4.1 may be a novel therapeutic target for glioma. +genetics_overexpression_suppress 33693959 hsa-mir-7 Esophageal Squamous Cell Carcinoma On the whole, the findings of the present study suggest that LincIN is overexpressed and plays an oncogenic role in ESCC via the regulation of the NF90/miR7/HOXB13 axis. +genetics_knock down_promote 33693951 hsa-mir-619 Retinoblastoma Rescue experiments revealed that the overexpression of HDAC9 or the inhibition of miR36195p reversed the inhibition of RB cell viability, migration and invasion induced by the knockdown of HCP5. +circulation_biomarker_diagnosis_ns 33693036 hsa-mir-125b Vascular Calcification Multiple logistic regression was done to evaluate the relationship between circulating miR-125b levels, VC presence and severity, followed by selecting the optimal cutoff point for VC diagnosis. +genetics_knock down_promote 33692859 hsa-mir-1301 Carcinoma, Non-Small-Cell Lung 3p knockdown. +genetics_knock down_promote 33692839 hsa-mir-27b Squamous Cell Carcinoma of Head and Neck TRIM14was shown to be a direct target of miR-27b-3p, and TRIM14 overexpression abolished the effect of miR-27b-3p on DDP sensitivity in DDP-resistant OSCC cells. +transcription factor target 33692838 hsa-mir-200b Cartilage Diseases These findings revealed the miR-200b/FUT4 axis as a potential candidate to target the degeneration of cartilages, thereby inhibiting the progression of OA. +lncRNA target 33692838 hsa-mir-200b Osteoarthritis These findings revealed the miR-200b/FUT4 axis as a potential candidate to target the degeneration of cartilages, thereby inhibiting the progression of OA. +circRNA target 33692802 hsa-mir-766 Arthritis, Rheumatoid Collectively, this study identified a novel circRNA Circ_0088194 that promotes RA-FLS invasion and migration via the miR +other 33692756 hsa-mir-182 Cushing Syndrome 5p as a possible biomarker for CD, which has to be validated in a prospective cohort. +genetics_GWAS 33692439 hsa-mir-138 Cartilage Diseases This study aimed to examine the molecular mechanism of enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2)/microRNA-138 (miR-138)/syndecan 1 (SDC1) and its epigenetic regulation in cartilage degeneration in OA. +genetics_GWAS 33692439 hsa-mir-138 Osteoarthritis This study aimed to examine the molecular mechanism of enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2)/microRNA-138 (miR-138)/syndecan 1 (SDC1) and its epigenetic regulation in cartilage degeneration in OA. +other 33692368 hsa-mir-122 Severe Dengue 5p and miR-146a-5p with DHF liver pathogenesis, involving endothelial repair and vascular permeability regulation, control of homeostasis and expression of inflammatory cytokines. +other 33692368 hsa-mir-146a Severe Dengue 5p and miR-146a-5p with DHF liver pathogenesis, involving endothelial repair and vascular permeability regulation, control of homeostasis and expression of inflammatory cytokines. +other 33692368 hsa-mir-126 Severe Dengue 5p and miR-146a-5p with DHF liver pathogenesis, involving endothelial repair and vascular permeability regulation, control of homeostasis and expression of inflammatory cytokines. +lncRNA target 33692340 hsa-mir-155 Atherosclerosis Taken together, these results suggest that CTRP12 protects against atherosclerosis by enhancing RCT efficiency and mitigating vascular inflammation via the miR5p/LXRalpha pathway. +exosome 33692334 hsa-mir-483 Fibrosis, Renal Our results expounded that HNRNPA1-mediated exosomal sorting transported cellular miR +exosome 33692334 hsa-mir-483 Diabetic Nephropathies Our results expounded that HNRNPA1-mediated exosomal sorting transported cellular miR +genetics_overexpression_promote 33691630 hsa-mir-25 Colorectal Neoplasms Overexpression of miR +transcription factor target 33691628 hsa-mir-132 Osteoarthritis PI3K inhibitor increased the destructive effect of the miR-132 inhibitor on osteoarthritis. +lncRNA target 33691558 hsa-mir-151b Osteoporosis MiR-151b might serve as a novel therapeutic target for osteoporosis. +lncRNA target 33691558 hsa-mir-151b Oophoritis ABBREVIATIONS: miR-151b: microRNA-151b; miRNAs: microRNAs; Msx2: Msh homeobox 2; MAPK: mitogen-activated protein kinase; STAT: signal transducer and activator of transcription; SD: Sprague-Dawley; BMD: bone mineral density; qRT-PCR: quantitative reverse transcription PCR; MTT: methyl thiazolyl tetrazolium; OVX: ovariectomy; ALP: alkaline phosphatase. +other 33691396 hsa-mir-467c Pars Planitis Based on miRNA microarray and reverse transcription-quantitative polymerase chain reaction (PCR) results, the expression levels of miR-7010 and miR-467c decreased, while miR-132 and miR-182 expression increased in the human BMSCs of patients with POP. +genetics_overexpression_suppress 33691396 hsa-mir-182 Pars Planitis Finally, in vivo experimental results showed that the biomechanical characteristics of bone tissues in POP rats were significantly enhanced by miR-182 inhibition, while they were significantly weakened by miR-182 overexpression. +other 33691396 hsa-mir-7010 Pars Planitis Based on miRNA microarray and reverse transcription-quantitative polymerase chain reaction (PCR) results, the expression levels of miR-7010 and miR-467c decreased, while miR-132 and miR-182 expression increased in the human BMSCs of patients with POP. +other 33691396 hsa-mir-132 Pars Planitis Based on miRNA microarray and reverse transcription-quantitative polymerase chain reaction (PCR) results, the expression levels of miR-7010 and miR-467c decreased, while miR-132 and miR-182 expression increased in the human BMSCs of patients with POP. +circulation_biomarker_diagnosis_up 33690683 hsa-mir-1246 Esophageal Squamous Cell Carcinoma The expression of miR-1246 in the blood and urine was significantly higher in the patients with esophageal squamous cell carcinoma than in 50 healthy control subjects. The results indicate that the levels of miR-1246 in the urine, saliva, and serum are a useful biomarker for esophageal squamous cell carcinoma and support the use of urine samples instead of blood samples for noninvasive diagnosis. +lncRNA target 33689215 hsa-mir-188 Liver Cirrhosis 5p inhibitors to investigate the therapeutic effects of miR +circulation_biomarker_diagnosis_ns 33688482 hsa-mir-106b Asthma Plasma levels of IL-5 and IL-13 were non-significantly higher in asthmatic children compared to healthy children, and there was no significant correlation between them and both miR-146a and miR-106b expressions in the asthmatic children. +circulation_biomarker_diagnosis_ns 33688482 hsa-mir-146a Asthma Plasma levels of IL-5 and IL-13 were non-significantly higher in asthmatic children compared to healthy children, and there was no significant correlation between them and both miR-146a and miR-106b expressions in the asthmatic children. +other 33688447 hsa-mir-137 Alzheimer Disease MicroRNA-137 (miRNA-137) was found as a suitable biomarker for AD, and the sensing method was established here to detect miRNA-137 on the complementary sequence. Further control sequences of miRNA-21 and single and triple base mismatched miRNA-137 did not show a significant response in current changes, indicating the specific miRNA-137 detection for diagnosing AD. +genetics_overexpression_promote 33688254 hsa-mir-621 Leukemia, Myeloid, Acute In AML cells, miR-621 overexpression downregulated the expression of SNHG10, while SNHG10 overexpression could not affect the expression of miR-621. +lncRNA target 33688211 hsa-mir-211 Prostatic Neoplasms CONCLUSION: This study showed that lncRNA KCNQ1OT1, as a ceRNA, upregulated CHI3L1 and promoted PCa progression through competitive binding to miR +genetics_knock down_promote 33688203 hsa-mir-223 Lymphoma, Mantle-Cell Importantly, CHUK overexpression promoted proliferation and suppressed apoptosis of MCL cells, whereas CHUK knockdown reversed down-regulated miRNA +other 33687998 hsa-mir-145 Heart Diseases Our results show that miR-145 is selectively misregulated in HGPS and that the consequent up-regulation of LOX is causal for premature arterial stiffening and cardiac dysfunction. +other 33687998 hsa-mir-145 Progeria Our results show that miR-145 is selectively misregulated in HGPS and that the consequent up-regulation of LOX is causal for premature arterial stiffening and cardiac dysfunction. +exosome 33687910 hsa-mir-210 Lung Neoplasms Collectively, exosomal miR-210 targeted and negatively regulated RUNX3 expression to promote malignant properties of lung cancer cells by potentiating PI3K/AKT signaling pathway. +transcription factor target 33687637 hsa-mir-133b Osteoporosis These findings revealed that miR-133b can promote the viability and differentiation of osteoblasts by targeting GNB4, hoping to lay a feasible theoretical foundation for the clinical treatment of osteoporosis. +lncRNA target 33687636 hsa-mir-675 Pulmonary Arterial Hypertension HOXA-AS3 increased the development of PAH via regulation of miR3p/PDE5 axis, which could be the potential biomarker for treatment of PAH. +genetics_knock down_promote 33687619 hsa-mir-2467 Carcinoma, Non-Small-Cell Lung 3p overexpression suppressed cell proliferation, migration and invasion and facilitated cell apoptosis of NSCLC cells. +other 33687386 hsa-mir-21 Breast Neoplasms This work aims to develop a cost-effective and label-free electrochemical biosensor to detect miRNA-21, a biomarker of breast cancer. +lncRNA target 33687075 hsa-mir-7515 Adenocarcinoma of Lung Moreover, we demonstrated that FAM201A affected LUAD progression via targeting miR-7515 to promote GLO1 expression. +genetics_knock down_promote 33686961 hsa-mir-7160 Carcinoma, Non-Small-Cell Lung Furthermore, miR-7160 overexpression induced apoptosis activation in NSCLC cells. +genetics_knock down_promote 33686960 hsa-mir-765 Ovarian Neoplasms BRD4 KO in ovarian cancer cells abolished the functional impact of miR-765. +genetics_knock down_suppress 33686957 hsa-mir-106a Breast Neoplasms Moreover, the overexpression of STAT3 and miR-106a-5p inhibitor could reverse circRHOT1 knockdown-mediated breast cancer progression. +lncRNA target 33686956 hsa-mir-195 Brain Injuries, Traumatic Collectively, astrocyte-derived EVs carrying NKILA was found to alleviate neuronal injury in TBI by competitively binding to miR-195 and upregulating NLRX1. +lncRNA target 33686956 hsa-mir-195 Nerve Degeneration Collectively, astrocyte-derived EVs carrying NKILA was found to alleviate neuronal injury in TBI by competitively binding to miR-195 and upregulating NLRX1. +genetics_overexpression_promote 33686878 hsa-mir-1254 Squamous Cell Carcinoma of Head and Neck METHODS: Proliferation and invasion experiments were performed in the OSCC cell line CAL-27 in which miR-1254 was overexpressed or inhibited. +genetics_knock down_promote 33686766 hsa-mir-101 Periodontitis EZH2 was overexpressed, while miR-101 was downregulated in the OCs of periodontitis. +other 33686713 hsa-mir-193a Colorectal Neoplasms CONCLUSION: Taken together, we identified in CRC the MCM3AP-AS1/miR-193a-5p/SENP1 regulatory axis, which affords a therapeutic possibility for CRC. +transcription factor target 33686586 hsa-mir-181a Lymphoma ANP32A was a direct target gene of gga-miR-181a and they were implicated in MD lymphoma tumorigenesis. +transcription factor target 33686586 hsa-mir-181a Distal myopathy, Nonaka type In our previous study on miRNome analysis of MDV-induced lymphoma in chicken, we found that gga-miR-181a was downregulated drastically in MDV-infected spleens. To further investigate the role of gga-miR-181a in MDV-induced lymphomagenesis, we performed cell migration assay, and the results suggested that gga-miR-181a suppressed the migration of MDV-transformed lymphoid cell (MSB-1). +transcription factor target 33686586 hsa-mir-181a Lymphoma, Follicular ANP32A was a direct target gene of gga-miR-181a and they were implicated in MD lymphoma tumorigenesis. +transcription factor target 33686586 hsa-mir-181a Muscular Dystrophies ANP32A was a direct target gene of gga-miR-181a and they were implicated in MD lymphoma tumorigenesis. +genetics_knock down_promote 33686550 hsa-mir-6838 Carcinoma, Renal Cell 5p enhanced cell proliferation and invasion in human RCC cell lines (ACHN and 786-O), which were detected by CCK-8, Transwell and Colony formation assays (P < 0.05), and knockdown of miR +circRNA target 33685455 hsa-mir-132 Colorectal Neoplasms CONCLUSION: Circ_DOCK1 interference suppressed cell growth and metastasis, and increased apoptosis of colorectal cancer via decreasing USP11 by increasing miR3p. +transcription factor target 33685449 hsa-mir-137 Esophageal Squamous Cell Carcinoma CONCLUSION: CTCF/Suz12/EZH2 complex-silenced miR-137 facilitates ESCC progression and radioresistance by targeting EZH2 and PXN. +genetics_knock down_suppress 33685441 hsa-mir-155 Carcinoma, Hepatocellular 5p inhibitor or ZBTB18 overexpression. +circRNA target 33685351 hsa-mir-382 Colorectal Neoplasms 5p/EN2 axis, and circ_0000467 is a promising target for CRC therapy. +lncRNA target 33685301 hsa-mir-1290 ankylosing spondylitis 1 In conclusion, our study demonstrated that hsa_circ_0056558 and CDK6 suppressed cell proliferation and differentiation while enhanced cell apoptosis by competitive binding to miR-1290 in AS, which might be possibly achieved by PI3K/AKT/NF-kappaB pathway, providing us novel therapeutic strategy for AS. +genetics_overexpression_promote 33685293 hsa-mir-143 Lung Neoplasms TMPO-AS1 and CDK1 were overexpressed in LC tissues and cells, while miR +lncRNA target 33684878 hsa-mir-20a Diabetic Nephropathies Therefore, miR-20a-5p may be a promising biomarker and therapeutic target during asthma progression by regulating ATG7-modulated autophagy. +lncRNA target 33684878 hsa-mir-20a Asthma, Allergic Therefore, miR-20a-5p may be a promising biomarker and therapeutic target during asthma progression by regulating ATG7-modulated autophagy. +lncRNA target 33684878 hsa-mir-20a Inflammation Therefore, miR-20a-5p may be a promising biomarker and therapeutic target during asthma progression by regulating ATG7-modulated autophagy. +genetics_knock down_suppress 33684877 hsa-mir-515 Osteoarthritis CONCLUSION: Circ_0134111 knockdown alleviated apoptosis, inflammatory responses and ECM degradation in OA cell model by mediating the miR5p-SOCS1 network, hinting that circ_0134111 was involved in OA progression. +genetics_overexpression_suppress 33684690 hsa-mir-384 Carcinoma, Non-Small-Cell Lung Furthermore, curcumin impeded viability, colony formation, migration, invasion, and accelerated apoptosis of NSCLC cells, but these impacts were partially reversed by circ-PRKCA elevation, miR-384 downregulation, or ITGB1 overexpression. +lncRNA target 33684620 hsa-mir-18a Spinal Fractures By inhibiting ADCY5, miR-18a-3p promotes osteoporosis and possibly contributes to spinal fracture. In general, miR-18a-3p targets ADCY5 to promote OP and may be involved in spinal fracturs. +lncRNA target 33684620 hsa-mir-18a Osteoporosis By inhibiting ADCY5, miR-18a-3p promotes osteoporosis and possibly contributes to spinal fracture. In general, miR-18a-3p targets ADCY5 to promote OP and may be involved in spinal fracturs. +lncRNA target 33683171 hsa-mir-29a Triple Negative Breast Neoplasms YY1-induced transcriptional activation of DUXAP8 promotes TNBC cell growth through miR-29a-3p/SAPCD2 axis. +other 33683013 hsa-mir-876 Precursor Cell Lymphoblastic Leukemia-Lymphoma 3p/RBBP6 axis to activate the JNK signaling pathway. +genetics_knock down_promote 33682985 hsa-mir-145 Stomach Neoplasms 5p increased the expression levels of KCNQ1OT1 and also attenuated the effects of knockdown of KCNQ1OT1 on the viability, proliferation and apoptosis of GC cells. +exosome 33682961 hsa-mir-1169 Carcinoma, Non-Small-Cell Lung CONCLUSION: The exosomal miR-1169 and miR-260 as potential candidates, which contain specific characteristics that can distinguish between wild-type EGFR and mutant EGFR NSCLC patients in early-stage cancers. +exosome 33682961 hsa-mir-260 Carcinoma, Non-Small-Cell Lung CONCLUSION: The exosomal miR-1169 and miR-260 as potential candidates, which contain specific characteristics that can distinguish between wild-type EGFR and mutant EGFR NSCLC patients in early-stage cancers. +lncRNA target 33682796 hsa-mir-141 Cystic Fibrosis We established a CRISPR/Cas9-based protocol to target miR-141 in primary human bronchial epithelial cells that were differentiated at air-liquid-interface, and goblet cell hyperplasia was induced by IL-13 stimulation. miR-141 disruption resulted in decreased goblet cell frequency, intracellular MUC5AC, and total secreted mucus. +lncRNA target 33682796 hsa-mir-141 Gastritis, Hypertrophic We established a CRISPR/Cas9-based protocol to target miR-141 in primary human bronchial epithelial cells that were differentiated at air-liquid-interface, and goblet cell hyperplasia was induced by IL-13 stimulation. +genetics_knock down_suppress 33682697 hsa-mir-37 Carcinoma, Non-Small-Cell Lung Meanwhile, circRNA_100565 knockdown contributed to the anti-tumor effects of DDP on NSCLC in vivo.CONCLUSION: CircRNA_100565 was an independent prognostic factor for NSCLC patient survival, and enhanced the resistance of NSCLC cells to cisplatin by regulating cell proliferation, apoptosis and autophagy via miR3p/ADAM28 axis, shedding light on the development of a novel therapeutic strategy to boost the effectiveness of NSCLC chemotherapy. +lncRNA target 33682607 hsa-mir-152 Lymphoma, Large B-Cell, Diffuse Furthermore, both the immune escape and progression of DLBCL are advanced by SNHG14 expression via its interactions with miR +transcription factor target 33682507 hsa-mir-494 Reperfusion Injury, Hepatic Ischemia CONCLUSION: Propofol plays a vital role in preventing myocardial cell apoptosis and improvement of cardiac function by suppressing miR-494 in a hepatic I/R injury rat model. +other 33682215 hsa-mir-1 Skin Neoplasms, Non-Melanoma 3p in lesional epidermis that could negatively regulate seven oncogenic transcription factors, FOXC1, AR, SP1, YY1, GLI2, TP53 and RARA, known to be over-expressed in SCC or BCC. +other 33682215 hsa-mir-194 Skin Neoplasms, Non-Melanoma 3p in lesional epidermis that could negatively regulate seven oncogenic transcription factors, FOXC1, AR, SP1, YY1, GLI2, TP53 and RARA, known to be over-expressed in SCC or BCC. +other 33682215 hsa-mir-194 Skin Neoplasms 3p in lesional epidermis that could negatively regulate seven oncogenic transcription factors, FOXC1, AR, SP1, YY1, GLI2, TP53 and RARA, known to be over-expressed in SCC or BCC. +other 33682215 hsa-mir-1 Skin Neoplasms 3p in lesional epidermis that could negatively regulate seven oncogenic transcription factors, FOXC1, AR, SP1, YY1, GLI2, TP53 and RARA, known to be over-expressed in SCC or BCC. +lncRNA target 33681892 hsa-mir-4443 Atrial Fibrillation hsa-miR-4443 protected AF by targeting THBS1 and regulated TGF-beta1/alpha-SMA/collagen pathway to inhibit HCFB proliferation and collagen synthesis. +other 33681353 hsa-mir-599 Heart Injuries Therefore, miR-599 could be a promising therapeutic approach for the management of cardiac injury under oxidative condition. +transcription factor target 33681349 hsa-mir-21 Acute Lung Injury In conclusion, for the first time, we found that miR5p could directly suppress mitophagy and mitochondrial damage during HALI formation. +transcription factor target 33681349 hsa-mir-21 Bronchopulmonary Dysplasia In conclusion, for the first time, we found that miR5p could directly suppress mitophagy and mitochondrial damage during HALI formation. +exosome 33681295 hsa-mir-590 Stomach Neoplasms 5p, an exosome with its own clinical characteristics. +other 33681184 hsa-mir-199a Carcinoma, Non-Small-Cell Lung MiR-199a-5p-HIF-1α-STAT3 Positive Feedback Loop Contributes to the Progression of Non-Small Cell Lung Cancer. +lncRNA target 33681183 hsa-mir-96 Myocardial Infarction circPostn, miR5p, and BNIP3 are potential targets for the treatment of MI-caused heart injury. +other 33681178 hsa-mir-5001 Colorectal Neoplasms CONCLUSION: CCMAlnc/miR5p/HES6 signaling is strongly activated to promote CRC malignance. +other 33680975 hsa-mir-637 Stomach Neoplasms These results suggest that the circHIPK3/miR-637/AKT1 regulatory pathway may be associated with the oncogene and growth of gastric cancer. In short, a new circular RNA circHIPK3 and its function are identified, and the regulatory pathway of circHIPK3/miR-637/AKT1 in the tumorigenesis and development of gastric cancer is discovered. +lncRNA target 33680969 hsa-mir-150 Pancreatic Carcinoma 5p/E2F3 regulatory axis may be taken as an alternative therapeutic target for treating PC. +lncRNA target 33680941 hsa-mir-590 Esophageal Squamous Cell Carcinoma 3p/MDM2 axis might serve as potential therapeutic targets for ESCC patients. +lncRNA target 33680937 hsa-mir-185 Carcinoma, Renal Cell Our results revealed that downregulated ASB16-AS1 promotes ccRCC progression via a miR +lncRNA target 33680937 hsa-mir-214 Carcinoma, Renal Cell Our results revealed that downregulated ASB16-AS1 promotes ccRCC progression via a miR +lncRNA target 33680929 hsa-mir-140 Esophageal Squamous Cell Carcinoma 3p, which could inhibit the tumorigenesis and progression of ESCC through upregulating E2F3 expression. +other 33680910 hsa-mir-20b Leukemia, Myeloid, Acute To assess the prognostic impact of miR-20b on AML in the presence of other clinical and molecular factors, we screened 90 AML patients receiving chemotherapy only and 74 also undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) from the Cancer Genome Atlas (TCGA) database. In conclusion, our findings suggest that high miR-20b expression is a poor prognostic indicator for AML, but allo-HSCT may override its prognostic impact. +lncRNA target 33680908 hsa-mir-181c Squamous Cell Carcinoma of Head and Neck Collectively, our findings indicated that miR-181c-5p acted as an EMT suppressor miRNA by downregulation of SERPINE1 in LSCC and offers novel strategies for the prevention of metastasis in LSCC. +circulation_biomarker_diagnosis_up 33680906 hsa-mir-1539 Colorectal Neoplasms When combined with clinicopathological data, serum miR-1539 levels were positively associated with vascular endothelial growth factor (VEGF) expression (p = 0.028), whilst levels in CRC tissue were positively associated with increased Ki-67 levels (p = 0.035). +genetics_overexpression_promote 33680718 hsa-mir-105-1 Ovarian Neoplasms 1 in OC cells, we silenced or overexpressed Hsa-miR +genetics_knock down_promote 33680120 hsa-mir-146b Pancreatic Carcinoma The results also suggested that miR-146b-5p overexpression inhibited the progression of PC cells by modulating Robo1. +therapeutic target 33680112 hsa-mir-339 Prostatic Neoplasms miR-339-5p may serve as an independent prognostic biomarker and therapeutic target for the treatment of prostate cancer. +genetics_knock down_promote 33680106 hsa-mir-497 Cicatrix, Hypertrophic 5p inhibitor inhibited cell viability, decreased extracellular matrix deposition and induced apoptosis in hHSFs, which were significantly reversed by Smad7 knockdown. +genetics_GWAS 33680048 hsa-mir-148a Ovarian Neoplasms re-expression of miR-148a and miR-152 by epigenetic therapy aiming to DNMT1 suppression might resensitize resistant ovarian tumors to conventional chemotherapy. +genetics_GWAS 33680048 hsa-mir-152 Ovarian Neoplasms re-expression of miR-148a and miR-152 by epigenetic therapy aiming to DNMT1 suppression might resensitize resistant ovarian tumors to conventional chemotherapy. +circulation_biomarker_diagnosis_ns 33680027 hsa-mir-24 Cardiovascular Diseases Our findings propose that TMZ has protective effects on decreased plasma miR-24 and miR-126 levels, inflammation, dyslipidemia and hypotension, and it may participate in endothelial dysfunction and atherosclerosis. +circulation_biomarker_diagnosis_ns 33680027 hsa-mir-24 Diabetes Mellitus, Type 2 Our findings propose that TMZ has protective effects on decreased plasma miR-24 and miR-126 levels, inflammation, dyslipidemia and hypotension, and it may participate in endothelial dysfunction and atherosclerosis. +circulation_biomarker_diagnosis_ns 33680027 hsa-mir-24 Hypotension Our findings propose that TMZ has protective effects on decreased plasma miR-24 and miR-126 levels, inflammation, dyslipidemia and hypotension, and it may participate in endothelial dysfunction and atherosclerosis. +circulation_biomarker_diagnosis_ns 33680027 hsa-mir-126 Diabetes Mellitus, Type 2 Our findings propose that TMZ has protective effects on decreased plasma miR-24 and miR-126 levels, inflammation, dyslipidemia and hypotension, and it may participate in endothelial dysfunction and atherosclerosis. +circulation_biomarker_diagnosis_ns 33680027 hsa-mir-126 Hypotension Our findings propose that TMZ has protective effects on decreased plasma miR-24 and miR-126 levels, inflammation, dyslipidemia and hypotension, and it may participate in endothelial dysfunction and atherosclerosis. +circulation_biomarker_diagnosis_ns 33680027 hsa-mir-126 Inflammation Our findings propose that TMZ has protective effects on decreased plasma miR-24 and miR-126 levels, inflammation, dyslipidemia and hypotension, and it may participate in endothelial dysfunction and atherosclerosis. +circulation_biomarker_diagnosis_ns 33680027 hsa-mir-24 Inflammation Our findings propose that TMZ has protective effects on decreased plasma miR-24 and miR-126 levels, inflammation, dyslipidemia and hypotension, and it may participate in endothelial dysfunction and atherosclerosis. +circulation_biomarker_diagnosis_ns 33680027 hsa-mir-126 Cardiovascular Diseases Our findings propose that TMZ has protective effects on decreased plasma miR-24 and miR-126 levels, inflammation, dyslipidemia and hypotension, and it may participate in endothelial dysfunction and atherosclerosis. +transcription factor target 33679879 hsa-mir-466h Carotid Stenosis Meanwhile, miR-466h-5p was specifically upregulated in the plaque rupture group compared with the atherosclerotic plaque group. miR-466h-5p may promote atherosclerotic plaque rupture via apoptosis-related pathways. +transcription factor target 33679879 hsa-mir-466h Thrombosis Meanwhile, miR-466h-5p was specifically upregulated in the plaque rupture group compared with the atherosclerotic plaque group. miR-466h-5p may promote atherosclerotic plaque rupture via apoptosis-related pathways. +other 33679865 hsa-mir-17 Breast Neoplasms miR-663, miR-210, miR-17, miR-301a, miR-135b, miR-451, miR-30a, and miR-199a-5p were screened to be highly relevant to lung metastasis (LM) of BC patients. Subgroup analysis showed that miR-30a, miR-135b, and miR-17 have unique roles in lung metastasis of BC. +other 33679865 hsa-mir-135b Breast Neoplasms miR-663, miR-210, miR-17, miR-301a, miR-135b, miR-451, miR-30a, and miR-199a-5p were screened to be highly relevant to lung metastasis (LM) of BC patients. Subgroup analysis showed that miR-30a, miR-135b, and miR-17 have unique roles in lung metastasis of BC. +transcription factor target 33679792 hsa-mir-132 Dermatitis Herpetiformis In summary, this study demonstrates that TCDD and FICZ have divergent effects on DTH response and T cell differentiation, which is mediated through, at least in part, regulation of miRNA-132 that targets HMGB1. +other 33679688 hsa-mir-27b Herpes Simplex 3p, when compared to healthy controls. +other 33679688 hsa-mir-199b Herpes Simplex 3p, when compared to healthy controls. +other 33679688 hsa-mir-369 Herpes Simplex 3p, when compared to healthy controls. +other 33679655 hsa-mir-29b Virus Diseases The role of microRNA-29b (miR-29b) in the majority of human cancers has been well demonstrated, but its significance in viral infections is yet to be elaborated. +other 33679417 hsa-mir-511 Periodontitis 3p/TLR4 axis that regulates the function of hPDLSCs in periodontitis, providing novel insight and scientific base in the treatment of periodontal tissue regeneration based on stem cells. +other 33679405 hsa-mir-194 Hepatic Veno-Occlusive Disease 5p, might serve as potential biomarkers for PA-induced HSOS in clinics. +other 33678493 hsa-mir-196a Rosacea NEAT1 may have functioned as a competing endogenous RNA which regulated inflammatory responses in rosacea by sponging miR-196a-5p and upregulating S100A9 expression. +other 33678324 hsa-mir-125b Hamartoma Syndrome, Multiple CONCLUSIONS: The BBOX1-AS1-hsa-miR-125b-5p/hsa-miR-125a-5p-CDKN2A ceRNA network is of great value in CC development. +other 33678324 hsa-mir-125a Hamartoma Syndrome, Multiple CONCLUSIONS: The BBOX1-AS1-hsa-miR-125b-5p/hsa-miR-125a-5p-CDKN2A ceRNA network is of great value in CC development. +circulation_biomarker_diagnosis_up 33678159 hsa-mir-125b Alveolar echinococcosis RESULTS: hsa-miR-125b-5p was stably upregulated in the plasma and liver tissue samples from patients with AE. CONCLUSIONS: The results suggest that hsa-miR-125b-5p may be a promising biomarker for early, non-invasive diagnosis of AE. +transcription factor target 33678118 hsa-mir-129 Retinoblastoma miR-129 directly targeted MDM2/4 to inhibit expression, therefore counteracting MDM2/4-mediated p53 signaling suppression and modulating RB cell proliferation and apoptosis. +circulation_biomarker_diagnosis_ns 33678000 hsa-mir-421 Metabolic Diseases Conclusion: Circulating miR-421 is a potential biomarker for insulin resistance, metabolic dysregulation and inflammatory status in patients with MetS. +circulation_biomarker_diagnosis_ns 33678000 hsa-mir-421 Inflammation Conclusion: Circulating miR-421 is a potential biomarker for insulin resistance, metabolic dysregulation and inflammatory status in patients with MetS. +lncRNA target 33677813 hsa-mir-126 Hypothyroidism In conclusion, dysregulation of the NEAT1/miR-126/TRAF7 axis is responsible for impaired endothelial functions in SCH. +genetics_knock down_suppress 33677804 hsa-mir-298 Ischemic Stroke CONCLUSION: SNHG1 knockdown enhanced OGD/R-induced injury in bEnd3 cells by regulating miR-298/SIK1 axis, which might provide promising therapeutic target for treatment of ischemic stroke. +lncRNA target 33677577 hsa-mir-146b Crohn Disease Thus, a specific MALAT1-miR-146b-5p-NUMB/CLDN11 pathway that plays a vital role in maintaining intestinal mucosal homeostasis may serve as a novel target for CD treatment. +lncRNA target 33677310 hsa-mir-876 Arthritis, Gouty CONCLUSION: In conclusion, TGP suppressed MSU-induced inflammation in THP-1 macrophages through regulating MALAT1/miR5p/NLRP3 axis and TLR4/MyD88/NF-kappaB pathway, suggesting that TGP was a promising active ingredient for gouty arthritis treatment. +transcription factor target 33677255 hsa-mir-25 Sepsis These results indicated that GA could improve sepsis-induced renal damage by attenuating renal inflammation and apoptosis via upregulating miR-25 with Nox4 as the target. +lncRNA target 33676964 hsa-mir-1287 Retinoblastoma In addition, depletion of circ_0099198 inhibited RB cell progression via regulating miR-1287/LRP6 axis. +circulation_biomarker_diagnosis_ns 33676945 hsa-mir-122 Cardiomyopathies METHODS: A set of circulating microRNAs linked to cardiac fibrosis (mir-1, mir-21, mir-29a, mir-29b, mir-101, mir-122, mir-133a) were measured at baseline in 198 patients in the biomarker substudy of Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS). +circulation_biomarker_diagnosis_ns 33676945 hsa-mir-29b Myocardial Infarction, Acute METHODS: A set of circulating microRNAs linked to cardiac fibrosis (mir-1, mir-21, mir-29a, mir-29b, mir-101, mir-122, mir-133a) were measured at baseline in 198 patients in the biomarker substudy of Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS). +circulation_biomarker_diagnosis_ns 33676945 hsa-mir-133a Cardiomyopathies METHODS: A set of circulating microRNAs linked to cardiac fibrosis (mir-1, mir-21, mir-29a, mir-29b, mir-101, mir-122, mir-133a) were measured at baseline in 198 patients in the biomarker substudy of Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS). CONCLUSION: Although serum mir-133a was associated with PICP change, none of the microRNAs previously linked to cardiac fibrosis predicted an antifibrotic response to eplerenone. +circulation_biomarker_diagnosis_ns 33676945 hsa-mir-29a Myocardial Infarction, Acute METHODS: A set of circulating microRNAs linked to cardiac fibrosis (mir-1, mir-21, mir-29a, mir-29b, mir-101, mir-122, mir-133a) were measured at baseline in 198 patients in the biomarker substudy of Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS). +circulation_biomarker_diagnosis_ns 33676945 hsa-mir-29a Cardiomyopathies METHODS: A set of circulating microRNAs linked to cardiac fibrosis (mir-1, mir-21, mir-29a, mir-29b, mir-101, mir-122, mir-133a) were measured at baseline in 198 patients in the biomarker substudy of Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS). +circulation_biomarker_diagnosis_ns 33676945 hsa-mir-21 Myocardial Infarction, Acute METHODS: A set of circulating microRNAs linked to cardiac fibrosis (mir-1, mir-21, mir-29a, mir-29b, mir-101, mir-122, mir-133a) were measured at baseline in 198 patients in the biomarker substudy of Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS). +circulation_biomarker_diagnosis_ns 33676945 hsa-mir-122 Myocardial Infarction, Acute METHODS: A set of circulating microRNAs linked to cardiac fibrosis (mir-1, mir-21, mir-29a, mir-29b, mir-101, mir-122, mir-133a) were measured at baseline in 198 patients in the biomarker substudy of Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS). +circulation_biomarker_diagnosis_ns 33676945 hsa-mir-1 Myocardial Infarction, Acute METHODS: A set of circulating microRNAs linked to cardiac fibrosis (mir-1, mir-21, mir-29a, mir-29b, mir-101, mir-122, mir-133a) were measured at baseline in 198 patients in the biomarker substudy of Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS). CONCLUSION: Although serum mir-133a was associated with PICP change, none of the microRNAs previously linked to cardiac fibrosis predicted an antifibrotic response to eplerenone. +circulation_biomarker_diagnosis_ns 33676945 hsa-mir-1 Cardiomyopathies METHODS: A set of circulating microRNAs linked to cardiac fibrosis (mir-1, mir-21, mir-29a, mir-29b, mir-101, mir-122, mir-133a) were measured at baseline in 198 patients in the biomarker substudy of Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS). CONCLUSION: Although serum mir-133a was associated with PICP change, none of the microRNAs previously linked to cardiac fibrosis predicted an antifibrotic response to eplerenone. +circulation_biomarker_diagnosis_ns 33676945 hsa-mir-21 Cardiomyopathies METHODS: A set of circulating microRNAs linked to cardiac fibrosis (mir-1, mir-21, mir-29a, mir-29b, mir-101, mir-122, mir-133a) were measured at baseline in 198 patients in the biomarker substudy of Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS). +circulation_biomarker_diagnosis_ns 33676945 hsa-mir-133a Myocardial Infarction, Acute METHODS: A set of circulating microRNAs linked to cardiac fibrosis (mir-1, mir-21, mir-29a, mir-29b, mir-101, mir-122, mir-133a) were measured at baseline in 198 patients in the biomarker substudy of Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS). CONCLUSION: Although serum mir-133a was associated with PICP change, none of the microRNAs previously linked to cardiac fibrosis predicted an antifibrotic response to eplerenone. +circulation_biomarker_diagnosis_ns 33676945 hsa-mir-29b Cardiomyopathies METHODS: A set of circulating microRNAs linked to cardiac fibrosis (mir-1, mir-21, mir-29a, mir-29b, mir-101, mir-122, mir-133a) were measured at baseline in 198 patients in the biomarker substudy of Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS). +other 33676670 hsa-mir-494 Uterine Cervical Neoplasms The miR-494 expresses in cancerous and normal living cells of human cervical carcinoma (HeLa), human lung carcinoma (A549), human breast cancer (MCF-7), and normal human mammary epithelial (MCF-10A) cells were imaged and localized with significantly improved sensitivity and specificity. +genetics_overexpression_suppress 33676551 hsa-mir-29 Rhinitis, Allergic RESULTS: Decreased expression of miR-29 was observed in AR, the symptoms of which were alleviated by overexpressing miR-29. +lncRNA target 33676464 hsa-mir-338 Intervertebral Disc Degeneration CONCLUSIONS: The results suggest that lncRNA AC063977.6 correlate with PFKFB2, the vital metabolic signature gene, via targeting miR +circulation_biomarker_diagnosis_ns 33676382 hsa-mir-145 ankylosing spondylitis 1 Monitoring the expression of miR-145 in plasma in AS patients may, therefore, influence our therapeutic decision-making. +lncRNA target 33676362 hsa-mir-524 Squamous Cell Carcinoma of Head and Neck Over-expression of miR-524 suppressed the proliferation, migration, and invasion of OSCC cells. +other 33676226 hsa-mir-16 Alcoholic Neuropathy Expression of MicroRNAs (miR-15b, miR-16, miR-138, miR-221, and miR-222) as Biomarkers of Endothelial Corpus Cavernosum Dysfunction in a Diabetic Alcoholic Murine Model. +other 33676226 hsa-mir-222 Alcoholic Neuropathy Expression of MicroRNAs (miR-15b, miR-16, miR-138, miR-221, and miR-222) as Biomarkers of Endothelial Corpus Cavernosum Dysfunction in a Diabetic Alcoholic Murine Model. +other 33676226 hsa-mir-16 Erectile Dysfunction Expression of MicroRNAs (miR-15b, miR-16, miR-138, miR-221, and miR-222) as Biomarkers of Endothelial Corpus Cavernosum Dysfunction in a Diabetic Alcoholic Murine Model. +other 33676226 hsa-mir-138 Alcoholic Neuropathy Expression of MicroRNAs (miR-15b, miR-16, miR-138, miR-221, and miR-222) as Biomarkers of Endothelial Corpus Cavernosum Dysfunction in a Diabetic Alcoholic Murine Model. +other 33676226 hsa-mir-222 Erectile Dysfunction Expression of MicroRNAs (miR-15b, miR-16, miR-138, miR-221, and miR-222) as Biomarkers of Endothelial Corpus Cavernosum Dysfunction in a Diabetic Alcoholic Murine Model. +other 33676226 hsa-mir-138 Erectile Dysfunction Expression of MicroRNAs (miR-15b, miR-16, miR-138, miR-221, and miR-222) as Biomarkers of Endothelial Corpus Cavernosum Dysfunction in a Diabetic Alcoholic Murine Model. +other 33676226 hsa-mir-15b Erectile Dysfunction Expression of MicroRNAs (miR-15b, miR-16, miR-138, miR-221, and miR-222) as Biomarkers of Endothelial Corpus Cavernosum Dysfunction in a Diabetic Alcoholic Murine Model. +other 33676226 hsa-mir-221 Erectile Dysfunction Expression of MicroRNAs (miR-15b, miR-16, miR-138, miR-221, and miR-222) as Biomarkers of Endothelial Corpus Cavernosum Dysfunction in a Diabetic Alcoholic Murine Model. +other 33676226 hsa-mir-15b Alcoholic Neuropathy Expression of MicroRNAs (miR-15b, miR-16, miR-138, miR-221, and miR-222) as Biomarkers of Endothelial Corpus Cavernosum Dysfunction in a Diabetic Alcoholic Murine Model. +other 33676226 hsa-mir-221 Alcoholic Neuropathy Expression of MicroRNAs (miR-15b, miR-16, miR-138, miR-221, and miR-222) as Biomarkers of Endothelial Corpus Cavernosum Dysfunction in a Diabetic Alcoholic Murine Model. +other 33675995 hsa-mir-1226 Breast Neoplasms Finally, TCGA data analysis and RT-qPCR against 20 pairs of Normal/Tumor breast tissues indicated that miR3p has been downregulated in breast cancer. +lncRNA target 33675923 hsa-mir-27a Stomach Neoplasms Taken together, these findings revealed that as a novel therapeutic target, APEX1/miR-27a-5p axis plays essential roles in modulating the GC development and MDR, and the GC targeted drug delivery formulation presents a strategic reference for the future designation of chemotherapeutics study. +transcription factor target 33675611 hsa-mir-607 Lung Neoplasms Moreover, miR-607 downregulation elevated cell viability, invasion and migration in LUSC cells, which was antagonized by si-CANT1. +other 33675584 hsa-mir-24 Reperfusion Injury, Cerebral Ischemia CONCLUSION: THRIL could aggravate cerebral ischemia-reperfusion injury by competitively binding to miR3p to promote the upregulation of NRP1 and further promoted the activation of the NF-kappaB p65 signaling pathway. +lncRNA target 33675502 hsa-mir-181a Cicatrix In conclusion, our study suggested that lncRNA TRHDE-AS1/miR-181a-5p/PTEN axis plays an important role in promoting hypertrophic scar formation, which may be effectively used as a therapeutic target for hypertrophic scar treatment. +epigenetics 33675468 hsa-mir-424 Colorectal Neoplasms RESULTS: Our results have revealed that the promoter region of miR-424 is methylated in cancer cells compared to normal cells, leading to downregulation of miR-424 in the colorectal cancer tissues compared to the normal tissues. +other 33675467 hsa-mir-34a Lung Neoplasms miRNA microarray analysis and polymerase-chain-reaction analysis of miRNAs revealed that treatment of human lung cancer A549 cells with apigenin up-regulated the level of miR-34a-5p. +other 33675278 hsa-mir-34c Nasopharyngeal Carcinoma Overall, this study suggested that c-Myc-induced circ-NOTCH1 promoted malignant phenotypes of NPC cells by regulating the miR-34c-5p/c-Myc axis. +circRNA target 33675276 hsa-mir-495 Squamous Cell Carcinoma of Head and Neck OSCC progression and immune evasion were regulated by circKRT1 via the miR +lncRNA target 33675274 hsa-mir-1271 Bone Diseases, Metabolic 5p as a target in the treatment of osteoporosis and other bone metabolic diseases. +lncRNA target 33675274 hsa-mir-1271 Osteoporosis 5p as a target in the treatment of osteoporosis and other bone metabolic diseases. +genetics_knock down_promote 33675175 hsa-mir-671 Osteoarthritis 5p overexpression alleviated IL-1beta-mediated chondrocyte apoptosis, inflammatory injury, and extracellular matrix degradation via decreasing TCF4 expression. +genetics_overexpression_promote 33675129 hsa-mir-873 Squamous Cell Carcinoma of Head and Neck CONCLUSION: Overexpression of miR +genetics_overexpression_promote 33674778 hsa-mir-625 Melanoma 5p or overexpressing IGF-1R. +circulation_biomarker_diagnosis_ns 33674633 hsa-mir-21 Cardiovascular Diseases Multivariable logistic regression revealed that subjects with high circulating miR-21 and miR-29a individual levels had a significantly higher risk of total death, cancer death, and CVD death than those with medium miR-21 and miR-29a individual levels. +circulation_biomarker_diagnosis_ns 33674633 hsa-mir-29a Cardiovascular Diseases Multivariable logistic regression revealed that subjects with high circulating miR-21 and miR-29a individual levels had a significantly higher risk of total death, cancer death, and CVD death than those with medium miR-21 and miR-29a individual levels. +circRNA target 33674567 hsa-mir-1298 Glioma 5p/ITGA could be a potential therapeutic target for reversing the resistance of glioma to TMZ. +other 33674273 hsa-mir-135a Pancreatic Carcinoma Moreover, we found miR-135a-5p was significantly associated with the prognosis of patients with pancreatic cancer and could be a candidate biomarker to predict gemcitabine response. +other 33673143 hsa-mir-34a Breast Neoplasms Here, we show that miR-34a and miR-200c levels are reduced in breast tumors compared to adjacent normal tissues and that this additively predicts poor patient survival. We establish a model, supported by in vitro and clinical data, which collectively suggest that the co-delivery of miR-34a and miR-200c represents a promising novel therapeutic strategy for breast cancer patients. +other 33673143 hsa-mir-200c Breast Neoplasms Here, we show that miR-34a and miR-200c levels are reduced in breast tumors compared to adjacent normal tissues and that this additively predicts poor patient survival. We establish a model, supported by in vitro and clinical data, which collectively suggest that the co-delivery of miR-34a and miR-200c represents a promising novel therapeutic strategy for breast cancer patients. +transcription factor target 33673073 hsa-mir-27b non-alcoholic fatty liver Here, we concluded that chronic Western diet-composition administered for 20 weeks may surpass the non-alcoholic fatty liver (NAFL) stage but may be at an intermediate stage between fatty liver and fibrosis via miR-27b-5p-induced PPARgamma downregulation. +transcription factor target 33673073 hsa-mir-27 non-alcoholic fatty liver Here, we concluded that chronic Western diet-composition administered for 20 weeks may surpass the non-alcoholic fatty liver (NAFL) stage but may be at an intermediate stage between fatty liver and fibrosis via miR-27b-5p-induced PPARgamma downregulation. +other 33672625 hsa-mir-140 Postural Orthostatic Tachycardia Syndrome 3p, 323a-3p, 340-5p, and 361-5p were significantly downregulated in MVP compared to CTRL (p C (rs17337023) polymorphism located in the EGFR 3' untranslated region (3'UTR), the rs884225 polymorphism located in the sequence of miR-214, and the single nucleotide polymorphisms (SNPs) rs325797437, rs344501106, rs81286029 and rs318656749 located in the promoter of lncRNA MEG3. Our study confirmed that the T > C substitution of rs884225 polymorphism located in miR-214 binding site in the 3'UTR of EGFR is associated with increased risk of primary hypertension. +genetics_overexpression_promote 33635477 hsa-mir-219 Spinal Cord Compression overexpressing OPCs (miR-219 OPCs) were transplanted in animal models of spinal cord injury to evaluate the impact of miR-219 on oligodendrocyte differentiation and functional recovery in vivo. +transcription factor target 33635243 hsa-mir-384 Myocardial Reperfusion Injury 3p inhibition remarkably reduced I/R-induced MI in rats. +circulation_biomarker_diagnosis_ns 33635234 hsa-let-7a Arthritis, Rheumatoid CONCLUSIONS: The increased circulating miR +circulation_biomarker_diagnosis_ns 33635234 hsa-mir-22 Arthritis, Rheumatoid CONCLUSIONS: The increased circulating miR +lncRNA target 33635226 hsa-mir-548m Lupus Erythematosus, Systemic CONCLUSIONS: X-linked miR-548m might target PTEN and play a role in SLE, which revealed a new molecular mechanism of X-linked miRNA in the development of SLE. +lncRNA target 33635017 hsa-mir-206 Sepsis CONCLUSION: The lncRNA RMRP contributes to sepsis-induced AKI through upregulation of DDX5 in a miR-206 dependent manner and through activation of NLRP3 inflammasome. +transcription factor target 33634974 hsa-mir-378a Carcinoma, Hepatocellular Such mechanism may indicate a potential tumor suppressor role of MiR-378a-3p and the impact of its abnormal expression on the cell growth and invasion of HCC. The results confirmed the prediction by our proposed model that miR-378a-3p was a putative biomarker for diagnosis and prognosis of HCC. +lncRNA target 33634966 hsa-mir-384 Urinary Bladder Neoplasms FTO facilitates the tumorigenesis of bladder cancer through regulating the MALAT/miR-384/MAL2 axis in m6A RNA modification manner, which ensures the potential of FTO for serving as a diagnostic or prognostic biomarker in bladder cancer. +genetics_knock down_suppress 33634427 hsa-mir-1205 Colorectal Neoplasms In vivo, circRAD23B knockdown also reduced CRC tumorigenesis via the miR-1205/TRIM44 axis. CONCLUSION: These results suggested that the inhibition of circRAD23B retarded the progression of CRC via acting on the miR-1205/TRIM44 axis. +other 33634115 hsa-mir-143 Ovarian Neoplasms The Cancer-Testis Long Non-coding RNA PCAT6 Facilitates the Malignant Phenotype of Ovarian Cancer by Sponging miR-143-3p. +exosome 33634112 hsa-mir-128 Colorectal Neoplasms Exosomal miR-128-3p Promotes Epithelial-to-Mesenchymal Transition in Colorectal Cancer Cells by Targeting FOXO4 via TGF-β/SMAD and JAK/STAT3 Signaling. +other 33634097 hsa-mir-378a Prostatic Neoplasms In conclusion, our findings demonstrated that circPDHX facilitated the proliferation and invasion of PCa cells by sponging miR-378a-3p. +lncRNA target 33634016 hsa-mir-191 Colonic Neoplasms To sum up, ELFN1-AS1 drives colon cancer cells to proliferate and invade through adjusting the miR5p/SATB1 axis. +target gene 33633805 hsa-mir-206 Colorectal Neoplasms MicroRNA-206 inhibits the proliferation, migration and invasion of colorectal cancer cells by regulating the c-Met/AKT/GSK-3β pathway. +other 33633582 hsa-mir-199a Cardiovascular Diseases Moreover, higher miR-199a-5p was involved in hypoxia-induced cardiovascular dysfunctions, thus contributing to poorer exercise endurance at high altitudes. +other 33633568 hsa-mir-155 Carcinoma, Non-Small-Cell Lung 5p) associated with SOCS1, BTG2, and BTK may be important in CA against NSCLC. +other 33633568 hsa-mir-7 Carcinoma, Non-Small-Cell Lung 5p) associated with SOCS1, BTG2, and BTK may be important in CA against NSCLC. +circRNA target 33633466 hsa-mir-142 Carcinoma, Non-Small-Cell Lung 3p inhibitor. +circulation_biomarker_diagnosis_up 33633196 hsa-mir-451 Arthritis, Rheumatoid A comprehensive analysis of miRNAs revealed the dysregulation of miR-451 in peripheral blood mononuclear cells (PBMC) and plasma from RA-risk individuals. +target gene 33632990 hsa-mir-140 Carcinoma, Hepatocellular Bie Jia Jian Pill Combined with Bone Mesenchymal Stem Cells Regulates microRNA-140 to Suppress Hepatocellular Carcinoma Stem Cells. +lncRNA target 33632317 hsa-mir-653 Osteoporosis CONCLUSION: MEL promotes BMSC osteogenic differentiation and inhibits OP pathogenesis by suppressing the expression of circ_0003865, which regulates GAS1 gene expression via sponging miR3p. +circulation_biomarker_diagnosis_up 33632305 hsa-mir-199a Pulmonary Fibrosis The expression of miR-199a-5p was significantly enhanced in the serum of IPF patients and IPF-MSCs compared with that of healthy donors and control-MSCs. +lncRNA target 33632232 hsa-mir-124 Triple Negative Breast Neoplasms According to recent studies, microRNA-124 (miR124) not only inhibits tumour growth but also increases the sensitivity of TNBC to paclitaxel (PTX), suggesting that a platform combining PTX and miR124 may be an advanced solution for TNBC. CONCLUSION: Based on these results, the codelivery of PTX and miR124 by the CaP/LNS nanosystem might be a promising therapeutic strategy for TNBC. +target gene 33632213 hsa-mir-625 Breast Neoplasms CircMMP11 regulates proliferation, migration, invasion, and apoptosis of breast cancer cells through miR-625-5p/ZEB2 axis. +transcription factor target 33632094 hsa-mir-19b Asthma RESULTS: miR-19b-3p and miR-320c were significantly dysregulated in moderate asthmatic patients in comparison with control group. +circulation_biomarker_diagnosis_up 33632094 hsa-mir-320c Asthma OBJECTIVE: The aim of the study is to investigate the level of expression of cell-free circulating miR-19b-3p and miR-320c in the blood plasma by comparing their plasma levels with IL-4 in the moderate BA patients and control group. BA patients showed a considerably positive correlation between the expression level of microRNA-320c and IL-4 levels. +circulation_biomarker_diagnosis_ns 33632085 hsa-mir-18a Uterine Cervical Neoplasms CONCLUSION Patients with HPV-positive cervical cancer have vaginal microbial dysbiosis and high serum levels of miR-18a and PD-L1. +lncRNA target 33632070 hsa-mir-21 Cardiomegaly Pre-transfection of miR-21 inhibitors could inhibit MV-induced cardiomyocyte hypertrophy. +other 33632070 hsa-mir-21 Kidney Diseases However, the role of microvesicles (MVs) containing miR-21 in CKD-related cardiomyocyte hypertrophy remains largely unexplored. +genetics_overexpression_promote 33631962 hsa-mir-24 Hypoxia In conclusion, MIR22HG overexpression aggravated hypoxia-induced injury in AC16 cardiomyocytes via enhancing NF-kappaB activation by targeting miR-24. +genetics_knock down_promote 33631962 hsa-mir-22 Myocardial Infarction In conclusion, MIR22HG overexpression aggravated hypoxia-induced injury in AC16 cardiomyocytes via enhancing NF-kappaB activation by targeting miR-24. +genetics_knock down_promote 33631962 hsa-mir-22 Hypoxia In conclusion, MIR22HG overexpression aggravated hypoxia-induced injury in AC16 cardiomyocytes via enhancing NF-kappaB activation by targeting miR-24. +genetics_knock down_promote 33631962 hsa-mir-24 Myocardial Infarction In conclusion, MIR22HG overexpression aggravated hypoxia-induced injury in AC16 cardiomyocytes via enhancing NF-kappaB activation by targeting miR-24. +other 33631423 hsa-mir-141 Pneumonia, Mycoplasma 3p expression was upregulated in the HUVECs isolated from PE tissues and hypoxia-induced HUVECs. +other 33631181 hsa-mir-499 Venous Thrombosis Microarray analysis and RT-PCR were performed to examine the expression level of miR-499 in thrombosis after curcumin administration. +transcription factor target 33631172 hsa-mir-361 Osteoporosis, Postmenopausal 5p, and then promote osteogenesis-angiogenesis, thus providing potential targets for PMOP treatment. +other 33630973 hsa-mir-451a Leukemia-Lymphoma, Adult T-Cell The significant up-regulation of FZD6, THBS4, and miR-451a as well as down-regulation of CPNE3, SIRT1, and miR3p were found in ATLL samples than normal samples. +other 33630973 hsa-mir-142 Leukemia-Lymphoma, Adult T-Cell The significant up-regulation of FZD6, THBS4, and miR-451a as well as down-regulation of CPNE3, SIRT1, and miR3p were found in ATLL samples than normal samples. +transcription factor target 33630713 hsa-mir-34c Mental Disorders Our previous study has found that miR-34c-5p was highly abundant in the ovary of goose with broodiness phenotype. Taken together, the data suggested that miR-34c-5p regulated granulosa cells apoptosis and brooding behavior by targeting Bcl2, which not only contribute to reveal the potential mechanism of miR-34c-5p underlying granulosa cells apoptosis in goose, but also provides an effective strategy to reduce the incidence of broodiness and improve the egg production. +other 33630421 hsa-let-7e Pulmonary Arterial Hypertension Collectively, our research reveals that a long noncoding RNA-miRNA-mRNA interaction network may be involved in the pathogenesis of PAH and suggests SNHG12, hsa-let-7e-5p and CCR7 as potential biomarkers for PAH. +genetics_overexpression_suppress 33630225 hsa-mir-129 Neuroblastoma 5p overexpression weakened the malignant biological behaviors of NB cells by targeting PLK4. +genetics_overexpression_suppress 33630215 hsa-mir-4262 Esophageal Neoplasms The effects of si-circ_0006948#1 on EC cells were partly restored by miR-4262 inhibition or FNDC3B overexpression. +transcription factor target 33630203 hsa-mir-495 Spinal Cord Injuries This study aims to investigate the role of miR-495 in neuronal cell apoptosis after acute spinal cord injury (ASCI). Overall, we concluded that miR-495 could inhibit neuronal cell apoptosis and relieve acute spinal cord injury through inhibiting PRDM5. +other 33630202 hsa-mir-363 Fibrosis This study aimed to explore the role of miR3p in renal fibrosis (RF) in vitro. +other 33630202 hsa-mir-363 Arthritis, Rheumatoid 3p plays a protective role in RF by regulating the TGF-beta2/Smad3 signaling pathway. +genetics_overexpression_suppress 33629893 hsa-mir-423 Diabetic Nephropathies 5p and overexpression of FOXA1 reversed the inhibitory effects of si-H19 on the inflammation and fibrosis of LPS-induced MH-S cells. +genetics_overexpression_suppress 33629893 hsa-mir-423 Respiratory Distress Syndrome 5p and overexpression of FOXA1 reversed the inhibitory effects of si-H19 on the inflammation and fibrosis of LPS-induced MH-S cells. +genetics_overexpression_suppress 33629893 hsa-mir-423 Inflammation 5p and overexpression of FOXA1 reversed the inhibitory effects of si-H19 on the inflammation and fibrosis of LPS-induced MH-S cells. +genetics_overexpression_suppress 33629893 hsa-mir-423 Lung Injury 5p and overexpression of FOXA1 reversed the inhibitory effects of si-H19 on the inflammation and fibrosis of LPS-induced MH-S cells. +exosome 33629796 hsa-mir-370 Breast Neoplasms Mechanistically, EV-encapsulated miR +lncRNA target 33629639 hsa-mir-98 Retinoblastoma 5p targeted XIAP to mediate RB cell development. +genetics_overexpression_promote 33629578 hsa-mir-621 Stomach Neoplasms MiR-621 overexpression inhibited viability, colony formation and proliferation of gastric cancer cells. +genetics_overexpression_promote 33629528 hsa-mir-19a Constipation Collectively, the results of this study established a regulatory relationship among circORC2, miR-19a and neurotensin/motilin, which indicated that the overexpression of circORC2 could up-regulate the levels of neurotensin and motilin, thus exerting a beneficial effect during the treatment of STC. +lncRNA target 33629321 hsa-mir-195 Diabetic Nephropathies CONCLUSIONS: MiR-195 reduces the release of inflammatory factors and inhibits the proliferation of macrophages through targeting TLR4 and blocking the NF-kappaB pathway, thereby alleviating the symptoms of DN rats. +genetics_GWAS 33629312 hsa-mir-155 Lupus Erythematosus, Systemic The aim of this study was to examine miR-155 rs767649 and miR-146a rs57095329 polymorphisms in SLE susceptibility in an Egyptian cohort and to investigate the correlation between them and clinical data and disease activity. +other 33629312 hsa-mir-146a Lupus Erythematosus, Systemic miR-155 and miR-146a were expressed in many autoimmune diseases such as rheumatoid arthritis. +lncRNA target 33629307 hsa-mir-185 Squamous Cell Carcinoma of Head and Neck UCA1 siRNA inhibited the proliferation and invasion of LSCC cells, moreover, the proliferation and invasion of LSCC cells were suppressed by miR +other 33629302 hsa-mir-3960 Colorectal Neoplasms OBJECTIVE: We aimed to determine the expression level of long intergenic non-coding ribonucleic acid 1605 (LINC01605) in colorectal cancer (CRC), and to explore the effects of the LINC01605/microRNA (miR)-3960/sex-determining region Y-box 11 (SOX11) regulatory axis on the biological behaviors of CRC cells and the molecular mechanism therein. CONCLUSIONS: LINC01605 has an up-regulated expression in CRC, and accelerates the proliferation, migration and metastasis of CRC cells by the miR-3960/SOX11 regulatory axis. +lncRNA target 33629299 hsa-mir-27a Carcinoma, Renal Cell CONCLUSIONS: LncRNA DNAJC3-AS1 acts as an oncogene and plays an essential role in the tumorigenesis of ccRCC, possibly via the regulation of the miR-27a-3p/PRDM14 axis. +circRNA target 33629298 hsa-mir-107 Urinary Bladder Neoplasms The role of circ0041103/miR-107/ FOXK1 axis in regulating BCa process was explored by rescue experiments. It stimulates BCa cells to proliferate and migrate via the miR-107/FOXK1 axis. +circRNA target 33629297 hsa-mir-1228 Prostatic Neoplasms CONCLUSIONS: Circ_0004417 inhibits the progression of prostate cancer through sponging miR-1228. +genetics_overexpression_suppress 33629295 hsa-mir-34a Ovarian Neoplasms Co-transfection found that overexpression of miR-34a-5p eliminated the biological behaviors of OC cells by TRIM44. +transcription factor target 33629292 hsa-mir-128 Osteoporosis 3p alleviates the progression of osteoporosis through inducing osteogenic differentiation of MSCs. +circulation_biomarker_diagnosis_ns 33629272 hsa-mir-378a Alzheimer Disease Logistic regression analysis established a model for AD prediction by serum exosomal miR-30b-5p, miR +circulation_biomarker_diagnosis_ns 33629272 hsa-mir-22 Alzheimer Disease Logistic regression analysis established a model for AD prediction by serum exosomal miR-30b-5p, miR +other 33628862 hsa-mir-181 Colorectal Adenocarcinoma Thus, the aim of this study was to determine the differential expressions profiles of MitomiRs (miR-24, miR-181, miR-210, miR-21 and miR378) in patients with colorectal adenomatous polyps tissues in correlation with clinicopathological tumor architectures of tubular, tubulovillous, villous adenomas and adenocarcinomas. +other 33628862 hsa-mir-378 Colorectal Adenocarcinoma Thus, the aim of this study was to determine the differential expressions profiles of MitomiRs (miR-24, miR-181, miR-210, miR-21 and miR378) in patients with colorectal adenomatous polyps tissues in correlation with clinicopathological tumor architectures of tubular, tubulovillous, villous adenomas and adenocarcinomas. +other 33628862 hsa-mir-21 Colorectal Adenocarcinoma Meanwhile, miR-21 increased progressively in adenoma tissues but decreased almost 2.5 folds in adenocarcinomas when compared to villous adenoma tissues (p < 0.001). +other 33628862 hsa-mir-24 Colorectal Adenocarcinoma Thus, the aim of this study was to determine the differential expressions profiles of MitomiRs (miR-24, miR-181, miR-210, miR-21 and miR378) in patients with colorectal adenomatous polyps tissues in correlation with clinicopathological tumor architectures of tubular, tubulovillous, villous adenomas and adenocarcinomas. +other 33628862 hsa-mir-210 Colorectal Adenocarcinoma Thus, the aim of this study was to determine the differential expressions profiles of MitomiRs (miR-24, miR-181, miR-210, miR-21 and miR378) in patients with colorectal adenomatous polyps tissues in correlation with clinicopathological tumor architectures of tubular, tubulovillous, villous adenomas and adenocarcinomas. +lncRNA target 33628831 hsa-mir-203 Nasopharyngeal Carcinoma Interestingly, there is a functional link between OIP5-AS1 and microRNA-203 (miR-203), a tumor suppressor, in NPC cells. In conclusion, our data demonstrate that OIP5-AS1 plays an important role in the development and progression of NPC by targeting miR-203 and therefore provide a promising target for the treatment of NPC. +other 33628829 hsa-mir-193a Glioma CONCLUSIONS: miR-193a-3p was upregulated in patients with glioma and could affect the invasion, migration, and MT of glioma by regulating BTRC. +genetics_overexpression_promote 33628799 hsa-mir-140 Carcinoma, Hepatocellular Additionally, overexpression experiments were conducted to investigate the biological role of miRNA-140 in HCC cells. +other 33628725 hsa-mir-429 Carcinoma, Non-Small-Cell Lung Conclusion The miR-200b and miR-429 molecules in tumor cells seem to have greatest impact on the effectiveness of immunotherapy in NSCLC patients. +other 33628725 hsa-mir-200b Carcinoma, Non-Small-Cell Lung Conclusion The miR-200b and miR-429 molecules in tumor cells seem to have greatest impact on the effectiveness of immunotherapy in NSCLC patients. +other 33628646 hsa-mir-214 Inflammation In recent years, studies have shown that miR-214 plays an important role in regulating several biological processes such as cell proliferation and differentiation, tumorigenesis, inflammation and immunity, and it has become a hotspot in the miRNA field. Finally, the value and application prospects of miR-214 as a molecular marker in inflammation and tumor related diseases were analyzed briefly. +other 33628646 hsa-mir-214 Neoplasms, Second Primary Finally, the value and application prospects of miR-214 as a molecular marker in inflammation and tumor related diseases were analyzed briefly. +genetics_GWAS 33628196 hsa-mir-133a-1 Diabetes Mellitus, Type 2 In SNP-environmental factors interaction analyses, there were interaction effects of miR-133a-2 rs13040413 with dyslipidemia, let-7a-1 rs13293512 with smoking, and let-7a-1 rs13293512 with dyslipidemia on T2DM. +genetics_GWAS 33628196 hsa-mir-133a-2 Diabetes Mellitus, Type 2 In SNP-environmental factors interaction analyses, there were interaction effects of miR-133a-2 rs13040413 with dyslipidemia, let-7a-1 rs13293512 with smoking, and let-7a-1 rs13293512 with dyslipidemia on T2DM. +genetics_GWAS 33628196 hsa-let-7a Diabetes Mellitus, Type 2 In SNP-SNP interaction analyses, there were also interaction effects of miR-133a-1 rs8089787 with let-7a-1 rs13293512, and miR-133a-1 rs8089787 with let-7f rs10877887 on T2DM. +genetics_GWAS 33628196 hsa-mir-133a Diabetes Mellitus, Type 2 In SNP-environmental factors interaction analyses, there were interaction effects of miR-133a-2 rs13040413 with dyslipidemia, let-7a-1 rs13293512 with smoking, and let-7a-1 rs13293512 with dyslipidemia on T2DM. +genetics_GWAS 33628196 hsa-let-7a-1 Diabetes Mellitus, Type 2 In SNP-SNP interaction analyses, there were also interaction effects of miR-133a-1 rs8089787 with let-7a-1 rs13293512, and miR-133a-1 rs8089787 with let-7f rs10877887 on T2DM. +lncRNA target 33628189 hsa-mir-142 Spinal Cord Injuries Conclusion: Our findings suggest that CTP may protect the spinal cord from SCI by suppression of apoptosis, oxidative stress and inflammatory response via miR-142/HMGB1/TLR4/NF-kappaB pathway. +genetics_overexpression_promote 33628056 hsa-mir-138 Colorectal Neoplasms Furthermore, circ_0006174 knock down-mediated suppression on cell proliferation, migration and invasion, and promotion on cell apoptosis could be alleviated by MACC1 overexpression or miR +lncRNA target 33628043 hsa-mir-138 Spinal Cord Injuries 5p to promote pyroptosis in inflammatory responses of LPS-induced acute lung injury by targeting NLRP3. +lncRNA target 33628043 hsa-mir-138 Acute Lung Injury 5p to promote pyroptosis in inflammatory responses of LPS-induced acute lung injury by targeting NLRP3. +genetics_knock down_promote 33628035 hsa-mir-145 Cholangiocarcinoma Also, MORC2 overexpression reversed the repressive impact of miR +lncRNA target 33628024 hsa-mir-216a Dementia, Vascular CONCLUSION: Idebenone inhibits the activation of RSK2/IkappaBalpha/NF-kappaB axis by increasing miR-216a, thus alleviating oxidative stress and neuroinflammation in VD rats. +other 33627769 hsa-mir-200c Lung Neoplasms miRNA-200C was increased in the FA defective lung cancers as compared to controls. +other 33627769 hsa-mir-200c Fanconi Anemia miRNA-200C was increased in the FA defective lung cancers as compared to controls. +other 33627711 hsa-let-7b Adenocarcinoma of Lung Ultimately, the co-expression analysis identified LINC00665-miR-let-7b-CCNA2 as the key ceRNA network associated with the prognosis of LUAD. +exosome 33627637 hsa-mir-126 Cartilage Diseases 3p expression was significantly reduced in OA patient-derived synovial fluid exosomes. +exosome 33627637 hsa-mir-126 Osteoarthritis 3p expression was significantly reduced in OA patient-derived synovial fluid exosomes. +genetics_overexpression_promote 33627627 hsa-mir-6780b Ovarian Neoplasms miR-6780b-5p overexpression promoted and miR-6780b-5p downregulation suppressed EMT of ovarian cancer cells. +circulation_biomarker_diagnosis_ns 33627414 hsa-mir-30 Ovarian Neoplasms Phenotypic switch was mediated by the transfer of plasma cell-derived exosomes containing miR3p into nonmesenchymal ovarian cancer cells. +transcription factor target 33627127 hsa-mir-491 Carcinoma, Hepatocellular MiR5p negatively regulated SEC61A1 and inhibited HCC cell proliferation and migration by targeting SEC61A1. +lncRNA target 33627057 hsa-mir-9 Nasopharyngeal Carcinoma 5p improved the radiosensitivity of NPC by targeting HK2. +circulation_biomarker_diagnosis_up 33627047 hsa-mir-141 Lung Neoplasms We found that the expression of miRNA-141 was up-regulated in the lung cancer serum exosomes compared with the normal serum exosomes. +other 33626544 hsa-mir-101-2 Herpes Simplex Previous studies reported that mir2 expression has widely participated in the regulation of HSV-1 replication. +other 33626544 hsa-mir-101-1 Herpes Simplex 1 into HeLa cells could reduce effectively HSV-1 replication using plaque assay and real-time PCR methods. +lncRNA target 33626373 hsa-mir-182 Neuralgia CONCLUSIONS: HAGLR aggravates neuropathic pain by sequestering miR5p from ATAT1 and activating NLRP3 inflammasome, which may provide a potential therapeutic target for neuropathic pain treatment. +lncRNA target 33625798 hsa-mir-874 Multiple Myeloma METHODS: Upon altering the expressions of hsa_circ_0003489, miR3p, and/or histone deacetylase 1 (HDAC1) in MM1.R cells and treating them with bortezomib (BTZ), cell viability was examined by CCK-8 assay; cell proliferation by Ki-67 immunofluorescence; apoptosis by TUNEL staining, flow cytometry, and western blot; and autophagy by electron microscopy and western blot. +other 33625672 hsa-mir-27a Urinary Bladder Neoplasms BACKGROUND: The study examines the function of hypoxia-mediated down-regulation of microRNAs (miRNAs) (mir-30c, mir-135a, and mir-27a) in the process of bladder cancer immune escape. +other 33625672 hsa-mir-135a Urinary Bladder Neoplasms BACKGROUND: The study examines the function of hypoxia-mediated down-regulation of microRNAs (miRNAs) (mir-30c, mir-135a, and mir-27a) in the process of bladder cancer immune escape. +other 33625263 hsa-mir-7156 Carcinoma, Renal Cell miR-1293, miR-34a, miR-551b, miR-937, miR-299, and miR2 were used in building the overall survival (OS)-related signature, whereas miR-7156, miR-211, and miR-301b were used to construct the formula of recurrence-free survival (RFS) with the help of LASSO Cox regression analysis. +other 33625263 hsa-mir-3199-2 Carcinoma, Renal Cell miR-1293, miR-34a, miR-551b, miR-937, miR-299, and miR2 were used in building the overall survival (OS)-related signature, whereas miR-7156, miR-211, and miR-301b were used to construct the formula of recurrence-free survival (RFS) with the help of LASSO Cox regression analysis. +other 33625263 hsa-mir-1293 Carcinoma, Renal Cell miR-1293, miR-34a, miR-551b, miR-937, miR-299, and miR2 were used in building the overall survival (OS)-related signature, whereas miR-7156, miR-211, and miR-301b were used to construct the formula of recurrence-free survival (RFS) with the help of LASSO Cox regression analysis. +other 33625263 hsa-mir-551b Carcinoma, Renal Cell miR-1293, miR-34a, miR-551b, miR-937, miR-299, and miR2 were used in building the overall survival (OS)-related signature, whereas miR-7156, miR-211, and miR-301b were used to construct the formula of recurrence-free survival (RFS) with the help of LASSO Cox regression analysis. +other 33625263 hsa-mir-211 Carcinoma, Renal Cell miR-1293, miR-34a, miR-551b, miR-937, miR-299, and miR2 were used in building the overall survival (OS)-related signature, whereas miR-7156, miR-211, and miR-301b were used to construct the formula of recurrence-free survival (RFS) with the help of LASSO Cox regression analysis. +other 33625263 hsa-mir-937 Carcinoma, Renal Cell miR-1293, miR-34a, miR-551b, miR-937, miR-299, and miR2 were used in building the overall survival (OS)-related signature, whereas miR-7156, miR-211, and miR-301b were used to construct the formula of recurrence-free survival (RFS) with the help of LASSO Cox regression analysis. +other 33625263 hsa-mir-299 Carcinoma, Renal Cell miR-1293, miR-34a, miR-551b, miR-937, miR-299, and miR2 were used in building the overall survival (OS)-related signature, whereas miR-7156, miR-211, and miR-301b were used to construct the formula of recurrence-free survival (RFS) with the help of LASSO Cox regression analysis. +genetics_knock down_promote 33625109 hsa-mir-448 Pancreatic Carcinoma Downregulation of miR-448 reversed the inhibition of migration and invasion of PC cells by DUXAP8 knockdown. +transcription factor target 33624729 hsa-mir-130b Osteoarthritis The effect of miR-130b on the viability, inflammation, apoptosis, and extracellular matrix of OA chondrocytes was studied. +epigenetics 33624428 hsa-mir-2861 Adenomyosis CONCLUSION: MIR22HG is downregulated in adenomyosis and upregulates miR-2861 through demethylation to inhibit endometrial cell proliferation. +epigenetics 33624428 hsa-mir-22 Adenomyosis CONCLUSION: MIR22HG is downregulated in adenomyosis and upregulates miR-2861 through demethylation to inhibit endometrial cell proliferation. +circulation_biomarker_diagnosis_ns 33623823 hsa-mir-128 Sepsis 3p was decreased, and TGFBR2 expression was increased in serum samples of sepsis patients and LPS-induced HK2 cells. +transcription factor target 33623407 hsa-mir-7a Diabetic Retinopathy CONCLUSION: miR-7a suppresses PI3K/Akt cascade via targeting IRS-2, thus decreasing the viability and invasion capacity of RPs and ECs, suggesting an interesting treatment target for DR. +transcription factor target 33623402 hsa-mir-125b Osteoporosis The present study investigates the role of miR-125b in postmenopausal osteoporosis. CONCLUSION: The outcomes suggested that miR-125b was responsible for the development of postmenopausal osteoporosis and promoted its progression by the TRAF6 gene via the JAK2/STAT3 pathway. +transcription factor target 33623121 hsa-mir-17 Inflammation The findings therefore suggest that miR3p is a potential therapeutic target/agent in the management of vascular inflammatory diseases. +circulation_biomarker_diagnosis_up 33622875 hsa-mir-28 Myopia 3p in the blood indicates a decrease in the optical density of the retinal pigment epithelium in those with myopia. +other 33622391 hsa-mir-23a Diabetes Mellitus, Type 2 We found three novel CpGs associated with prevalent T2D in Europeans at cg00144180 (HDAC4), cg16765088 (near SYNM) and cg24704287 (near MIR23A) and confirmed three CpGs previously identified (mapping to TXNIP, ABCG1 and CPT1A). +other 33622375 hsa-mir-4732 Prostatic Neoplasms 3p) are promising minimally invasive tools in prostate cancer clinical management. +other 33622375 hsa-mir-26b Prostatic Neoplasms Multivariate and ROC analyses show miR-26b-5p as a strong predictor of PCa, with an AUC of 0.89 (CI=0.83-0.95;p<0.001). +lncRNA target 33622363 hsa-mir-128 Colorectal Neoplasms CONCLUSION: In summary, we find that ZNF561-AS1 promotes CRC progression via the miR-26a-3p/miR +lncRNA target 33622363 hsa-mir-26a Colorectal Neoplasms CONCLUSION: In summary, we find that ZNF561-AS1 promotes CRC progression via the miR-26a-3p/miR +genetics_knock down_promote 33622094 hsa-mir-132 Uterine Cervical Neoplasms Moreover, overexpression of miR-132 restrained CC cell proliferation, migration, and invasion through targeting SOX4, and SNHG5 enhanced SOX4 expression via negatively regulating miR-132. +lncRNA target 33621956 hsa-mir-483 Osteoporosis, Postmenopausal 5p/SATB2 could be selected as a potential therapeutic target for PMOP. +genetics_overexpression_promote 33621954 hsa-mir-224 Uterine Cervical Neoplasms 3p overexpression reversed the inhibitory effect of RA on invasion and migration of CC cells, and it also restored the promoting effects of RA on cell cycle arrest and apoptosis. +genetics_overexpression_promote 33621940 hsa-mir-467b Encephalomyelitis, Autoimmune, Experimental Overexpression of miRNA-467b could suppress a percentage of CD4(+) IL-17(+) cells in EAE CD4 T cells in vitro. +genetics_overexpression_promote 33621688 hsa-mir-365 Multiple Myeloma The silencing of HOXA9 could also suppress the growth of the IM-9 myeloma cells while as the overexpression of HOXA9 could abolish the tumor-suppressive effects of miR-365. +target gene 33621591 hsa-mir-377 Squamous Cell Carcinoma of Head and Neck Down-regulating circular RNA_0004674 delays the progression of oral squamous cell carcinoma through microRNA-377-3p/THBS1 axis. +genetics_knock down_promote 33621431 hsa-mir-433 Carcinoma, Hepatocellular FXYD3-PI3K-AKT axis in the progression of HCC after loss- and gain-function assays. +exosome 33621425 hsa-mir-24 Colonic Neoplasms Altogether, CAF-derived exosomal miR +circRNA target 33621401 hsa-mir-433 Osteosarcoma In conclusion, it was demonstrated that circ_0002137 could restrain the progression of OS through regulating miR3p/IGF1R axis, providing a comprehensive landscape of circ_0002137 in the generation and development of OS. +lncRNA target 33621206 hsa-mir-506 Osteosarcoma In summary, miR-506 performs an anticancer activity via directly targeting Skp2 in osteosarcoma cells, indicating that inactivation of Skp2 by miR-506 might be an alternative strategy for treating osteosarcoma. +transcription factor target 33621197 hsa-mir-142 Diabetes Mellitus CONCLUSION: miR3p promotes the development of diabetes by inhibiting SPRED2-mediated autophagy, including inducing cell apoptosis, aggravating cellular oxidative stress and secretion of inflammatory factors, and resveratrol improves this effect. +other 33621196 hsa-mir-134 Osteosarcoma Thus, the current study aimed to elucidate the role of ELK1/miR-134/PTBP1 signaling cascade in osteosarcoma chemoresistance. Altogether, the key findings of the present study highlight ELK1/miR-134/PTBP1 signaling cascade as a novel molecular mechanism underlying the acquisition of osteosarcoma chemoresistance. +other 33621194 hsa-mir-138 Ovarian Neoplasms 5p/SDC3 axis was closely associated with OvC tumorigenesis and cisplatin resistance. +lncRNA target 33621133 hsa-mir-182 Urinary Bladder Neoplasms ADAMTS9-AS2 was a tumor suppressor that inhibited BC cell proliferation and induced cellular apoptosis by targeting miR5p, and it could be a promising target for BC treatment. +genetics_overexpression_promote 33620957 hsa-mir-520h Diabetes, Gestational The overexpression of mTOR alleviated miR-520h mimic-induced reduction in cell viability and enhancement in cell apoptosis in the GDM cell model. +other 33620707 hsa-mir-493 Teratozoospermia 5p, can suggest a regulatory network between these miRs and CRISP3 isoforms and suggest their regulatory roles in male infertility. +other 33620707 hsa-mir-92 Teratozoospermia 5p, can suggest a regulatory network between these miRs and CRISP3 isoforms and suggest their regulatory roles in male infertility. +other 33620707 hsa-mir-182 Teratozoospermia 5p, can suggest a regulatory network between these miRs and CRISP3 isoforms and suggest their regulatory roles in male infertility. +other 33620707 hsa-mir-192 Teratozoospermia 5p showed good AUC values which can be introduced as possible biomarkers of TZ. +genetics_overexpression_promote 33620674 hsa-mir-29a Reperfusion Injury, Cerebral Ischemia miR-29a in EVs protected OGD-treated cells and targeted TP53INP1, whose overexpression suppressed the protective function of EVs on OGD-treated cells. +transcription factor target 33620671 hsa-mir-26a Leukemia, Myeloid, Acute Inhibition of miR-26a-5p expression in AML-BMSC-EVs could abrogate the promoting effects of AML-BMSC-EVs on AML cell proliferation, migration, and invasion. +genetics_knock down_promote 33620119 hsa-mir-485 Melanoma 5p overexpression or PRRX1 knockdown suppressed epithelial-mesenchymal transition, cell viability, migration, and invasion, and promoted cell apoptosis in melanoma cells. +genetics_knock down_promote 33619796 hsa-mir-876 Carcinoma, Non-Small-Cell Lung 5p or overexpression of WNT5A reversed the circVAPA knockdown-mediated inhibition on cellular processes in NSCLC. +other 33619658 hsa-mir-134 Depression Behavioral results showed that the adult PDE female offspring was susceptible to depression, accompanied by increased hippocampal miR5p expression and decreased sex-determining region Y-box 2 (SOX2) expression, as well as disorders of neural progenitor cells proliferation and hippocampal neurogenesis. +circulation_biomarker_diagnosis_ns 33619372 hsa-mir-215 Essential Hypertension The aptamer, ThT dye, and the enzymatic strand displacement amplification (SDA) were used in a label-free approach to detect the micro RNA miR-215 in saliva and serum. +lncRNA target 33618745 hsa-mir-15 Carcinoma, Renal Cell Luciferase reporter assays showed that E2F transcription factor 3 (E2F3) was a target of miR +other 33618730 hsa-mir-155 Inflammation Translationally, MIR155 was detectable at high levels in bronchoalveolar fluid of patients with ARDS compared to healthy human subjects. +exosome 33618729 hsa-mir-7641 Breast Neoplasms Bioinformatics analysis has suggested that miR-7641 is correlated with breast cancer survival, and several important cellular and biological processes are closely targeted by miR-7641. Additionally, exosomal miR-7641 may serve as a promising non-invasive diagnostic biomarker and potential targetable candidate in breast cancer treatment. +lncRNA target 33618674 hsa-mir-423 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: ZNF674-AS1 suppresses NSCLC growth by downregulating miR +other 33618253 hsa-mir-541 Triple Negative Breast Neoplasms Moreover, HLA-F-AS1 acted as the molecular sponge of microRNA 541-3p (miR3p) to elevate TRABD (TraB domain containing) expression in TNBC cells. +transcription factor target 33618248 hsa-mir-92b Liver Cirrhosis Mechanistically, we found that miR-92b-3p promotes the activation of HSCs and thereby the progression of liver fibrosis by activating JAK/STAT pathway via targeting CREB3L2, providing a new target for the diagnosis and treatment of liver fibrosis. +lncRNA target 33617890 hsa-mir-338 Irritable Bowel Syndrome 3p potentially alter barrier function and visceral hypersensitivity via neuronal and MAPK signaling and could be therapeutic targets in IBS. +lncRNA target 33617890 hsa-mir-219a Irritable Bowel Syndrome 3p potentially alter barrier function and visceral hypersensitivity via neuronal and MAPK signaling and could be therapeutic targets in IBS. +genetics_knock down_promote 33617803 hsa-let-7a Colorectal Neoplasms Both CXCR4 overexpression and let-7a-5p knockdown alleviated the biological roles of cisatracurium in CRC cells. CONCLUSION: Cisatracurium suppressed the viability, metastasis and tumour growth of CRC by regulating the CXCR4/let-7a-5p axis via inhibiting TGF-beta/SMAD2/3 signalling. +genetics_overexpression_suppress 33617480 hsa-mir-646 Osteosarcoma MiR-646 expression was decreased and ARL2 was overexpressed in osteosarcoma cells (SAOS-2, HOS, MG-63 and U2OS) compared to hFOB1.19 cells. +lncRNA target 33617479 hsa-let-7e Carcinoma, Hepatocellular Therefore, the integrated results of our bioinformatics analyses of both clinical and experimental data showed that let-7e was a novel biomarker for HCC diagnosis and prognosis and might be a new treatment target. +circulation_biomarker_diagnosis_ns 33617143 hsa-mir-181a Lupus Nephritis SLE disease activity index, proteinuria and serum creatinine were independently correlated with miR-181a and miR-223 among SLE patients by linear regression analysis. +circulation_biomarker_diagnosis_up 33617143 hsa-mir-223 Lupus Erythematosus, Systemic Combined miR-181a and miR-223 expression analysis could serve as novel serum-based biomarkers in the diagnosis of SLE and predicting LN among Egyptians. +circulation_biomarker_diagnosis_up 33617143 hsa-mir-223 Lupus Nephritis Combined miR-181a and miR-223 expression analysis could serve as novel serum-based biomarkers in the diagnosis of SLE and predicting LN among Egyptians. +circulation_biomarker_diagnosis_ns 33617143 hsa-mir-181a Lupus Erythematosus, Systemic SLE disease activity index, proteinuria and serum creatinine were independently correlated with miR-181a and miR-223 among SLE patients by linear regression analysis. +lncRNA target 33616869 hsa-mir-143 Cognition Disorders In conclusion, Rian demonstrated neuroprotective effects against sevoflurane anesthesia-induced cognitive dysfunction through regulation of miR3p/LIMK1 axis, providing promising target for sevoflurane anesthesia-induced cognitive dysfunction. +exosome 33616347 hsa-mir-23a Diabetes Mellitus, Type 2 RESULTS: We found the exosomal levels of miR-23a and miR-192 were both significantly higher in T2D subjects. CONCLUSIONS: In conclusion, exosomal miR-23a and miR-192 have good potential as diagnostic biomarkers for type 2 diabetes. +exosome 33616347 hsa-mir-192 Diabetes Mellitus, Type 2 RESULTS: We found the exosomal levels of miR-23a and miR-192 were both significantly higher in T2D subjects. CONCLUSIONS: In conclusion, exosomal miR-23a and miR-192 have good potential as diagnostic biomarkers for type 2 diabetes. +circulation_biomarker_diagnosis_ns 33616326 hsa-mir-148a differentiated thyroid gland carcinoma RESULTS: We identified a novel exosomal miRNA, exosomal miR-148a-3p, that was significantly decreased in the serum of DTC patients compared with that of benign thyroid tumor patients and healthy controls. +circulation_biomarker_diagnosis_ns 33616325 hsa-mir-122 Dengue CONCLUSIONS: In summary, our study demonstrates that serum miRNA levels are affected by DENV1 infection, identifies novel DENV1-associated miRNAs, and suggests that Hsa-miR5p may be a potential biomarker for DENV1 infection. +lncRNA target 33615922 hsa-mir-29a Cataract Background: This in vitro study was designed to reveal the role of miR-29a in high glucose-induced cellular injury through the modulation of IL-6/STAT3 in diabetic cataracts.Methods: The expression of miR-29a and STAT3 in the lens capsules of patients with or without diabetes was determined by RT-PCR. Thus, miR-29a may be a potential therapeutic agent for diabetic cataracts. +lncRNA target 33615922 hsa-mir-29a Mitochondrial Diseases Background: This in vitro study was designed to reveal the role of miR-29a in high glucose-induced cellular injury through the modulation of IL-6/STAT3 in diabetic cataracts.Methods: The expression of miR-29a and STAT3 in the lens capsules of patients with or without diabetes was determined by RT-PCR. Thus, miR-29a may be a potential therapeutic agent for diabetic cataracts. +genetics_knock down_promote 33615686 hsa-mir-653 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma The knockdown of miR +circRNA target 33615661 hsa-mir-218 Diabetic Nephropathies In summary, our findings suggested that circEIF4G2 promotes renal tubular epithelial cell fibrosis via the miR-218/SERBP1 pathway, presenting a novel insight for DN treatment. +circRNA target 33615661 hsa-mir-218 Fibrosis, Renal In summary, our findings suggested that circEIF4G2 promotes renal tubular epithelial cell fibrosis via the miR-218/SERBP1 pathway, presenting a novel insight for DN treatment. +lncRNA target 33615521 hsa-mir-20a Fibrosis Our study elucidates the roles of the lnc-H19-miR-20a-5p-Tgfbr2 axis in regulating the TGFbeta/Smad pathway of myoblast fibrogenesis, which might provide a promising therapeutic target for skeletal muscle fibrosis. +lncRNA target 33615521 hsa-mir-20a Muscular Diseases Our study elucidates the roles of the lnc-H19-miR-20a-5p-Tgfbr2 axis in regulating the TGFbeta/Smad pathway of myoblast fibrogenesis, which might provide a promising therapeutic target for skeletal muscle fibrosis. +other 33615520 hsa-mir-200b Carcinoma, Hepatocellular CONCLUSIONS: H19 plays a critical role in HCC bone metastasis by reducing OPG expression, which is mediated by the PPP1CA-induced inactivation of the p38MAPK pathway; and H19 also functions as a sponge for miR-200b-3p. +circRNA target 33615474 hsa-mir-4465 Uterine Cervical Neoplasms In conclusion, circ_0102171 aggravates CC progression via targeting miR-4465/CREBRF axis. +genetics_GWAS 33615103 hsa-mir-186 Parathyroid Neoplasms 3p) were significantly deregulated in sPAs compared with NPT samples, suggesting a role for epigenetic changes in parathyroid tumorigenesis. +genetics_GWAS 33615103 hsa-mir-30 Parathyroid Neoplasms 3p) were significantly deregulated in sPAs compared with NPT samples, suggesting a role for epigenetic changes in parathyroid tumorigenesis. +genetics_GWAS 33615103 hsa-mir-135b Hyperparathyroidism, Primary 3p) were significantly deregulated in sPAs compared with NPT samples, suggesting a role for epigenetic changes in parathyroid tumorigenesis. +genetics_GWAS 33615103 hsa-mir-135b Parathyroid Neoplasms 3p) were significantly deregulated in sPAs compared with NPT samples, suggesting a role for epigenetic changes in parathyroid tumorigenesis. +genetics_GWAS 33615103 hsa-mir-1 Parathyroid Neoplasms 3p) were significantly deregulated in sPAs compared with NPT samples, suggesting a role for epigenetic changes in parathyroid tumorigenesis. +genetics_GWAS 33615103 hsa-mir-1 Hyperparathyroidism, Primary 3p) were significantly deregulated in sPAs compared with NPT samples, suggesting a role for epigenetic changes in parathyroid tumorigenesis. +genetics_GWAS 33615103 hsa-mir-30 Hyperparathyroidism, Primary 3p) were significantly deregulated in sPAs compared with NPT samples, suggesting a role for epigenetic changes in parathyroid tumorigenesis. +genetics_GWAS 33615103 hsa-mir-186 Hyperparathyroidism, Primary 3p) were significantly deregulated in sPAs compared with NPT samples, suggesting a role for epigenetic changes in parathyroid tumorigenesis. +genetics_GWAS 33615103 hsa-mir-17 Hyperparathyroidism, Primary 3p) were significantly deregulated in sPAs compared with NPT samples, suggesting a role for epigenetic changes in parathyroid tumorigenesis. +genetics_GWAS 33615103 hsa-mir-17 Parathyroid Neoplasms 3p) were significantly deregulated in sPAs compared with NPT samples, suggesting a role for epigenetic changes in parathyroid tumorigenesis. +genetics_GWAS 33615103 hsa-mir-29b Hyperparathyroidism, Primary 3p) were significantly deregulated in sPAs compared with NPT samples, suggesting a role for epigenetic changes in parathyroid tumorigenesis. +genetics_GWAS 33615103 hsa-mir-24 Hyperparathyroidism, Primary 3p) were significantly deregulated in sPAs compared with NPT samples, suggesting a role for epigenetic changes in parathyroid tumorigenesis. +genetics_GWAS 33615103 hsa-mir-24 Parathyroid Neoplasms 3p) were significantly deregulated in sPAs compared with NPT samples, suggesting a role for epigenetic changes in parathyroid tumorigenesis. +genetics_GWAS 33615103 hsa-mir-29b Parathyroid Neoplasms 3p) were significantly deregulated in sPAs compared with NPT samples, suggesting a role for epigenetic changes in parathyroid tumorigenesis. +circulation_biomarker_diagnosis_ns 33614632 hsa-mir-144 Ovarian Neoplasms Additionally, LINC01969, which primarily exists in the cytoplasm, boosted LARP1 expression by sponging miR +other 33614620 hsa-mir-24a Irritable Bowel Syndrome The downregulated zip1 interacted with miR-24a-3p and lnc017705, decreased osteoblast differentiation and Ca(2+) deposition in the IB_III stage. +circulation_biomarker_diagnosis_up 33614495 hsa-mir-214 Adenocarcinoma of Lung Exosomal miR-214 can be released by lung adenocarcinoma cells, enters peripheral circulation, and is taken up by osteoclasts, consequently stimulating osteoclast differentiation. +genetics_overexpression_promote 33614494 hsa-mir-21 Colorectal Neoplasms 5p overexpression caused downregulation of TGFBI, which may have led to pyroptosis. +genetics_overexpression_promote 33614488 hsa-mir-21 Carcinoma, Hepatocellular Overexpression of miR-21 in hepatoma cell line had shown increased phosphorylation p70S6K, the downstream regulator of cell proliferation in mTOR pathway. Overexpression of miR-21 has a role in HCC through mTOR pathway activation and can be targeted. +circulation_biomarker_diagnosis_ns 33614249 hsa-mir-223 Diabetes Mellitus, Type 2 Our findings provide mechanistic insights into the alteration of circulating miRNAs preceding T2D, unveiling both preadipocytes and adipocytes as miR +circulation_biomarker_diagnosis_ns 33614249 hsa-mir-223 Obesity Our findings provide mechanistic insights into the alteration of circulating miRNAs preceding T2D, unveiling both preadipocytes and adipocytes as miR +lncRNA target 33614242 hsa-mir-1224 Carcinoma, Hepatocellular Our findings identify a miR-1224/CREB feedback loop for HCC progression and that blocking this circuit may represent a promising target for HCC treatment. +genetics_knock down_promote 33614241 hsa-mir-22 Triple Negative Breast Neoplasms 3p loss contributes to TNBC growth and progression. +lncRNA target 33614238 hsa-mir-26a Pre-Eclampsia In conclusion, decreased MALAT1 expression in EOPE tissues reduces the glycolysis of ECs in a PFKFB3-dependent manner by sponging miR-26a/26b and inhibits EC proliferation, migration, and tube formation, which may contribute to abnormal angiogenesis in EOPE. +genetics_overexpression_promote 33614236 hsa-mir-30 Urinary Bladder Neoplasms 3p upregulation or silencing of RAI2 restored BC cell proliferation, invasion, and migration following overexpression of circRBPMS. +lncRNA target 33614234 hsa-mir-92b Heart Failure In conclusion, our present findings reveal a novel mechanism by which circPSD3 alleviates hepatic fibrogenesis by targeting the miR-92b-3p/Smad7 axis, and they also indicate that circPSD3 may serve as a potential biomarker for HF. +genetics_overexpression_promote 33614231 hsa-mir-1324 Carcinoma, Hepatocellular Furthermore, miR-1324 overexpression was capable of reversing the circFOXM1-induced malignant phenotypes and elevated expression of MECP2 in HCC cells. +lncRNA target 33614228 hsa-mir-637 Glioma In conclusion, we identified an oncogenic ZEB2/miR-637/HMGA1 signaling axis targeting vimentin that promotes both migration and invasion in glioma. +genetics_overexpression_promote 33614226 hsa-mir-29b Muscular Atrophy IGF1, PI3K(p85alpha), and Yin Yang 1 (YY1) were identified as target genes of miR-29b, and overexpression of these targets could rescue AngII-induced muscle atrophy. +other 33613970 hsa-mir-22 Myotonic Disorders Restoring miR-322/miR-503 levels could be an avenue for DM1 therapy. +other 33613970 hsa-mir-503 Myotonic Disorders Restoring miR-322/miR-503 levels could be an avenue for DM1 therapy. +exosome 33613846 hsa-mir-214 Carcinoma, Hepatocellular The present study tests the hypothesis that human cerebral endothelial cell-derived exosomes carrying elevated miR-214 (hCEC-Exo-214) can amplify the efficacy of anti-cancer drugs on HCC cells. +lncRNA target 33613764 hsa-mir-34a Ovarian Neoplasms By competitively binding miRNA-34a-5p, LINC00665 abolished the inhibitory effect of miR-34a-3p on its downstream gene E2F3, thus promoting OC progression. Conclusion: LINC00665/miRNA-34a-5p/E2F3 axis is involved in OC progression, providing novel insights into the clinical treatment of OC. +target gene 33613755 hsa-mir-1258 Colorectal Neoplasms circ_SMAD2 regulate colorectal cancer cells proliferation through targeting miR-1258/RPN2 signaling pathway. +other 33613724 hsa-mir-9 Colorectal Neoplasms MicroRNA-9-5p increases the sensitivity of colorectal cancer cells to 5-fluorouracil by downregulating high mobility group A2 expression. +target gene 33613721 hsa-mir-27a Lung Neoplasms Attenuating role of withaferin A in the proliferation and migration of lung cancer cells via a p53-miR-27a/miR-10b pathway. +target gene 33613721 hsa-mir-10b Lung Neoplasms Attenuating role of withaferin A in the proliferation and migration of lung cancer cells via a p53-miR-27a/miR-10b pathway. +transcription factor target 33613718 hsa-mir-527 Carcinoma, Hepatocellular This indicated that miR-527 in the HCC tissues may be an important novel miRNA that targets the GPC-3 gene expression. +genetics_overexpression_promote 33613714 hsa-mir-599 Colorectal Neoplasms Reverse transcription-quantitative PCR analysis demonstrated that miR-599 expression decreased in patients with CRC and in CRC cell lines, while miR-599 overexpression inhibited cell proliferation and migration abilities in vitro. +other 33613699 hsa-mir-21 Glioma CONCLUSION: This meta-analysis demonstrated that miRNA-21 has high diagnostic performance and could serve as a promising noninvasive diagnostic marker for glioma. +lncRNA target 33613672 hsa-mir-5581 Glioma Collectively, our study indicated LINC00526 serves as a tumor-suppressive lncRNA and directly regulates miR +exosome 33613526 hsa-mir-155 Cardiomegaly Further analyses demonstrated that HCs-derived exosomes induced the phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 via miR-155. +transcription factor target 33613190 hsa-mir-298 Campomelia Cumming type 5p-targeted Nox1. +lncRNA target 33613117 hsa-mir-106b Stomach Neoplasms Luciferase reporter assays revealed that HCP5 could compete with miR-106b-5p as a competing endogenous RNA (ceRNA) and upregulated p21 expression in GC. Conclusions: MEF2A-mediated HCP5 could exert an anti-tumor effect among the development of GC via miR-106b-5p/p21 axis, which provides a novel target for GC therapy. +lncRNA target 33613103 hsa-mir-619 Squamous Cell Carcinoma of Head and Neck 5p was the vital regulator for regulating cisplatin resistance of OSCC, which may be served as a potential therapeutic target. +lncRNA target 33613033 hsa-mir-5195 Carcinoma, Non-Small-Cell Lung 3p hindered NSCLC cells proliferation, EMT and accelerated apoptosis by directly targeting VEGFA. +lncRNA target 33612561 hsa-mir-199a Thyroid Cancer, Papillary Silencing NNT-AS1 inhibited PTC cell proliferation, migration and invasion, but promoted apoptosis via upregulation of miR-199a-5p. +other 33612481 hsa-mir-1273f Carcinoma, Non-Small-Cell Lung hsa_circ_0002874 downregulation could regulate miR1273f/MDM2/P53 signaling pathway to reverse the PTX resistance of NSCLC and induce apoptosis in vitro and vivo. +other 33612391 hsa-mir-34c Carcinoma, Ductal, Breast CONCLUSIONS: The chr22-38_28785274-29006793.1-miR-34a/c-5p-CAPN6 axis and the chr22-38_28785274-29006793.1-miR3p-SLC9A7 axis might regulate cellular activities associated with CD4+ and CD8+ T cell infiltration, respectively, in BRCA. +other 33612391 hsa-mir-34a Carcinoma, Ductal, Breast CONCLUSIONS: The chr22-38_28785274-29006793.1-miR-34a/c-5p-CAPN6 axis and the chr22-38_28785274-29006793.1-miR3p-SLC9A7 axis might regulate cellular activities associated with CD4+ and CD8+ T cell infiltration, respectively, in BRCA. +other 33611865 hsa-let-7 Chronic Rhinosinusitis With Nasal Polyps The miRNA-mRNA regulatory networks constructed with Cytoscape highlighted the roles of miR-154, miR-221, and miR-223 family miRNAs relating to both ECRSwNP and non-ECRSwNP, and the roles of the let-7 and miR-34/449 families in the development of non-ECRSwNP. +other 33611865 hsa-mir-449 Chronic Rhinosinusitis With Nasal Polyps The miRNA-mRNA regulatory networks constructed with Cytoscape highlighted the roles of miR-154, miR-221, and miR-223 family miRNAs relating to both ECRSwNP and non-ECRSwNP, and the roles of the let-7 and miR-34/449 families in the development of non-ECRSwNP. +other 33611865 hsa-let-7 Nasal Polyps The miRNA-mRNA regulatory networks constructed with Cytoscape highlighted the roles of miR-154, miR-221, and miR-223 family miRNAs relating to both ECRSwNP and non-ECRSwNP, and the roles of the let-7 and miR-34/449 families in the development of non-ECRSwNP. +other 33611865 hsa-mir-223 Chronic Rhinosinusitis With Nasal Polyps The miRNA-mRNA regulatory networks constructed with Cytoscape highlighted the roles of miR-154, miR-221, and miR-223 family miRNAs relating to both ECRSwNP and non-ECRSwNP, and the roles of the let-7 and miR-34/449 families in the development of non-ECRSwNP. +other 33611865 hsa-mir-221 Chronic Rhinosinusitis With Nasal Polyps The miRNA-mRNA regulatory networks constructed with Cytoscape highlighted the roles of miR-154, miR-221, and miR-223 family miRNAs relating to both ECRSwNP and non-ECRSwNP, and the roles of the let-7 and miR-34/449 families in the development of non-ECRSwNP. +other 33611865 hsa-mir-34 Nasal Polyps The miRNA-mRNA regulatory networks constructed with Cytoscape highlighted the roles of miR-154, miR-221, and miR-223 family miRNAs relating to both ECRSwNP and non-ECRSwNP, and the roles of the let-7 and miR-34/449 families in the development of non-ECRSwNP. +other 33611865 hsa-mir-154 Nasal Polyps The miRNA-mRNA regulatory networks constructed with Cytoscape highlighted the roles of miR-154, miR-221, and miR-223 family miRNAs relating to both ECRSwNP and non-ECRSwNP, and the roles of the let-7 and miR-34/449 families in the development of non-ECRSwNP. +other 33611865 hsa-mir-34 Chronic Rhinosinusitis With Nasal Polyps The miRNA-mRNA regulatory networks constructed with Cytoscape highlighted the roles of miR-154, miR-221, and miR-223 family miRNAs relating to both ECRSwNP and non-ECRSwNP, and the roles of the let-7 and miR-34/449 families in the development of non-ECRSwNP. +other 33611865 hsa-mir-154 Chronic Rhinosinusitis With Nasal Polyps The miRNA-mRNA regulatory networks constructed with Cytoscape highlighted the roles of miR-154, miR-221, and miR-223 family miRNAs relating to both ECRSwNP and non-ECRSwNP, and the roles of the let-7 and miR-34/449 families in the development of non-ECRSwNP. +other 33611865 hsa-mir-449 Nasal Polyps The miRNA-mRNA regulatory networks constructed with Cytoscape highlighted the roles of miR-154, miR-221, and miR-223 family miRNAs relating to both ECRSwNP and non-ECRSwNP, and the roles of the let-7 and miR-34/449 families in the development of non-ECRSwNP. +other 33611865 hsa-mir-221 Nasal Polyps The miRNA-mRNA regulatory networks constructed with Cytoscape highlighted the roles of miR-154, miR-221, and miR-223 family miRNAs relating to both ECRSwNP and non-ECRSwNP, and the roles of the let-7 and miR-34/449 families in the development of non-ECRSwNP. +other 33611865 hsa-mir-223 Nasal Polyps The miRNA-mRNA regulatory networks constructed with Cytoscape highlighted the roles of miR-154, miR-221, and miR-223 family miRNAs relating to both ECRSwNP and non-ECRSwNP, and the roles of the let-7 and miR-34/449 families in the development of non-ECRSwNP. +lncRNA target 33611856 hsa-mir-130a Arteriosclerosis Obliterans In conclusion, our data demonstrate that miR-130a inhibits VSMCs proliferation via ATG2B, which indicates that miR-130a could be a potential therapeutic target that regulates autophagy in atherosclerosis obliterans. +genetics_knock down_promote 33611825 hsa-mir-497 Thyroid Cancer, Papillary Gain- and loss-of-function assays indicated that miR +lncRNA target 33611824 hsa-mir-152 Uterine Cervical Neoplasms Apigenin suppresses proliferation, invasion, and induced EMT of cervical carcinoma cells by regulation of miR +genetics_knock down_promote 33611674 hsa-mir-128 Arthritis, Rheumatoid 3p overexpression or HDAC4 knockdown weakened the inhibitory effect of GAS5 or anti-miR +other 33611311 hsa-mir-196b Implantation Failure Following verification, hsa_circ_0038383/miR-196b-5p/HOXA9 axis may be a key pathway in affecting RIF. +other 33610945 hsa-mir-370 Behcet Syndrome 3p with BDNF levels. +other 33610945 hsa-mir-7 Behcet Syndrome 3p with BDNF levels. +other 33610945 hsa-mir-221 Behcet Syndrome 3p with BDNF levels. +other 33610945 hsa-mir-142 Behcet Syndrome 3p with BDNF levels. +other 33610732 hsa-mir-149 Infertility, Male Our results demonstrate that the expression profile of miR-149 with significantly decreased expression could be used as a first indication of early embryonic development and may provide novel insight into the biological background of idiopathic infertile males. +lncRNA target 33610681 hsa-mir-590 Stomach Neoplasms In conclusion, our data identified the genome binding sites of FOXI1, and provide evidence that FOXI1 inhibits gastric cancer cell proliferation by activating miR-590/ATF3 axis. +transcription factor target 33609809 hsa-mir-150 Bacterial Infections In this study, we examined the regulation mechanism and function of flounder miR-150 (named pol-miR-150) and its target gene LMP2L (named PoLMP2L) in association with bacterial and viral infection. +genetics_knock down_suppress 33609809 hsa-mir-150 Cytomegalovirus Infections We found that pol-miR-150 expression was not only modulated by the bacterial pathogen Streptococcus iniae but also by the viral pathogen megalocytivirus. In addition, pol-miR-150 knockdown also significantly inhibited the replication of megalocytivirus. +transcription factor target 33609644 hsa-mir-365 Melanoma Our findings suggested that inducing high expression of miR-365 might be a negative regulator of melanoma growth through activation of pro-apoptotic Bax, Caspase-9 and Caspase-3 that are essential to intrinsic apoptotic pathway. +genetics_knock down_suppress 33609602 hsa-mir-125a Spinal Cord Injuries Knockdown of miR-125a in B-Exo increased IRF5 expression in spinal cord tissues of SCI rats and attenuated the neuroprotective effect of B-Exo against SCI. +lncRNA target 33609562 hsa-mir-498 Carcinoma, Hepatocellular PRR34-AS1, TOMM20, and ITGA6 promoted HCC progression while miR-498 suppressed cell proliferation, migration, and invasion in HCC. +circulation_biomarker_diagnosis_up 33609405 hsa-mir-17 Multiple Myeloma The results showed that the plasma and mononuclear cell expression levels of miR +other 33609323 hsa-mir-137 Osteolysis, Essential 3p) involved in the regulation of osteoclast formation and activity or in the angiomatous proliferation was found in patients' cells. +other 33609323 hsa-mir-1246 Osteolysis, Essential 3p) involved in the regulation of osteoclast formation and activity or in the angiomatous proliferation was found in patients' cells. +other 33609323 hsa-mir-1 Osteolysis, Essential 3p) involved in the regulation of osteoclast formation and activity or in the angiomatous proliferation was found in patients' cells. +genetics_knock down_suppress 33609254 hsa-mir-199b Hypoxia-Ischemia, Brain CONCLUSIONS: Knockdown of SNHG14 attenuated ischemic brain injury by inhibiting inflammation and oxidative stress through the miR-199b/AQP4 axis. +circulation_biomarker_diagnosis_up 33609236 hsa-mir-139 Diabetic Retinopathy 5p antagomir effectively decreased the acellular capillaries and suppressed the formation of aberrant blood vessels in the retinal tissues. +lncRNA target 33609235 hsa-mir-340 Carcinoma, Renal Cell In conclusion, miR-340 promotes proliferation, migration, and invasion of RCC cells via suppressing FZD3 expression, and the promotion effect of miR-340 on RCC progression may be due to its regulatory effect on glycolysis and Ala level. +other 33608966 hsa-mir-195 Cardiovascular Diseases NEW FINDINGS: What is the central question of this study? What are the mechanisms underlying the cardiac protective effect of aerobic training in the progression of a high fructose-induced cardiometabolic disease in Wistar rats? What is the main finding and its importance? At the onset of cardiovascular disease, aerobic training activates the p-p70S6K, ERK and IRbeta-PI3K-AKT pathways, without changing the miR-126 and miR-195 levels, thereby providing evidence that aerobic training modulates the insulin signalling pathway. +other 33608966 hsa-mir-126 Cardiovascular Diseases NEW FINDINGS: What is the central question of this study? What are the mechanisms underlying the cardiac protective effect of aerobic training in the progression of a high fructose-induced cardiometabolic disease in Wistar rats? What is the main finding and its importance? At the onset of cardiovascular disease, aerobic training activates the p-p70S6K, ERK and IRbeta-PI3K-AKT pathways, without changing the miR-126 and miR-195 levels, thereby providing evidence that aerobic training modulates the insulin signalling pathway. +transcription factor target 33608866 hsa-mir-223 Syphilis 3p mimic reversed the effect of MSU on lowering cell viability, increasing pyroptosis in FLSs, while miR +genetics_overexpression_promote 33608112 hsa-mir-377 Breast Neoplasms PRNCR1 silencing or miR-377 overexpression resulted in suppressed breast cancer cell proliferation ability, blocked cell cycle process and induced apoptosis. +genetics_overexpression_promote 33608020 hsa-mir-378a Colorectal Neoplasms Finally, whether upregulation of CDK1 restores the inhibitory effect of overexpression of miR-378a-5p on the proliferation of CRC cells was studied by overexpression of CDK1. +lncRNA target 33607850 hsa-let-7d Esophageal Squamous Cell Carcinoma Furthermore, gene functional enrichment analysis revealed that the target genes of hsa-miR +lncRNA target 33607850 hsa-mir-186 Esophageal Squamous Cell Carcinoma Furthermore, gene functional enrichment analysis revealed that the target genes of hsa-miR +lncRNA target 33607460 hsa-mir-122 Cardiomyopathies 5p expression and subsequent downregulation of HIF-1alpha expression via direct interaction, which might finally result in the decrements of Smad2/3 and p-Smad2/3 expressions and increment of Smad7 expression. +other 33607255 hsa-mir-29a Inflammatory Bowel Diseases CONCLUSION: HuR competitively binds HMGB1 with miR-29a-3p to promote apoptosis of colonic epithelia in rats with UC. +lncRNA target 33607219 hsa-mir-183 Stomach Neoplasms These results indicate that BX357664 can inhibit the proliferation and metastasis of GC through the miR3p/PTEN/PI3K/AKT pathway, which may serve as potential targets for the treatment of GC in the future. +other 33607184 hsa-mir-221 Liver Cirrhosis In conclusion, both miR-221 & miR-542 could stand as a standalone biomarker for staging various HCV associated disorders. +other 33607184 hsa-mir-542 Liver Cirrhosis In conclusion, both miR-221 & miR-542 could stand as a standalone biomarker for staging various HCV associated disorders. +other 33607184 hsa-mir-221 Carcinoma, Hepatocellular In conclusion, both miR-221 & miR-542 could stand as a standalone biomarker for staging various HCV associated disorders. +other 33607184 hsa-mir-221 Hepatitis C In conclusion, both miR-221 & miR-542 could stand as a standalone biomarker for staging various HCV associated disorders. +other 33607184 hsa-mir-542 Hepatitis C In conclusion, both miR-221 & miR-542 could stand as a standalone biomarker for staging various HCV associated disorders. +other 33607184 hsa-mir-542 Carcinoma, Hepatocellular In conclusion, both miR-221 & miR-542 could stand as a standalone biomarker for staging various HCV associated disorders. +genetics_knock down_suppress 33607153 hsa-mir-204 Ischemic Stroke SIGNIFICANCE: RMST knockdown attenuated OGD-induced injury of HBMEC and bEnd.3 cells via regulating miR5p/VCAM1 axis, indicating a possible therapeutic strategy for future ischemic stroke therapy. +other 33607073 hsa-mir-20a Diabetic Retinopathy Five miRNAs (hsa-miR5p, hsa-miR-20a-5p, hsa-miR-20b-5p, hsa-miR-27b-3p and hsa-miR-451a) were validated as biomarkers for stratification of DR stages, from the early non-proliferative (NPDR) to the late proliferative (PDR) phase. +other 33607073 hsa-mir-27b Diabetic Retinopathy Five miRNAs (hsa-miR5p, hsa-miR-20a-5p, hsa-miR-20b-5p, hsa-miR-27b-3p and hsa-miR-451a) were validated as biomarkers for stratification of DR stages, from the early non-proliferative (NPDR) to the late proliferative (PDR) phase. +other 33607073 hsa-mir-20b Diabetic Retinopathy Five miRNAs (hsa-miR5p, hsa-miR-20a-5p, hsa-miR-20b-5p, hsa-miR-27b-3p and hsa-miR-451a) were validated as biomarkers for stratification of DR stages, from the early non-proliferative (NPDR) to the late proliferative (PDR) phase. +other 33607073 hsa-mir-195 Diabetic Retinopathy Five miRNAs (hsa-miR5p, hsa-miR-20a-5p, hsa-miR-20b-5p, hsa-miR-27b-3p and hsa-miR-451a) were validated as biomarkers for stratification of DR stages, from the early non-proliferative (NPDR) to the late proliferative (PDR) phase. +other 33607073 hsa-mir-451a Diabetic Retinopathy Five miRNAs (hsa-miR5p, hsa-miR-20a-5p, hsa-miR-20b-5p, hsa-miR-27b-3p and hsa-miR-451a) were validated as biomarkers for stratification of DR stages, from the early non-proliferative (NPDR) to the late proliferative (PDR) phase. +other 33606670 hsa-mir-21 Uterine Cervical Neoplasms BACKGROUND Previous studies have shown that miR-21 upregulation is related to the aggressive development of cervical cancer. We focus on the role of UTMD-mediated miR-21 transfection in HeLa cells, a cervical cancer cell line. +genetics_GWAS 33605830 hsa-mir-146a Behcet Syndrome METHODS: The distributions of miR-146a rs2910164 and UTS2 rs228648 (p.Thr21Met) variants were analyzed in 94 patients with BD and 115 healthy control subjects using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and Taqman Real-time PCR techniques. +lncRNA target 33605558 hsa-mir-194 Stomach Neoplasms miR-194 suppresses GC cell growth mainly through targeting CCND1 and induction of cell cycle arrest. +other 33605072 hsa-mir-499 Cardiovascular Diseases MicroRNA-499 (miR-499), microRNA-208a (miR-208a) and B-cell lymphoma 2 (Bcl-2) play roles in cardiovascular diseases, such as direct reprogramming of cardiac fibroblast into cardiomyocyte and cardiomyocyte apoptosis. +other 33605072 hsa-mir-208a Cardiovascular Diseases MicroRNA-499 (miR-499), microRNA-208a (miR-208a) and B-cell lymphoma 2 (Bcl-2) play roles in cardiovascular diseases, such as direct reprogramming of cardiac fibroblast into cardiomyocyte and cardiomyocyte apoptosis. +transcription factor target 33604823 hsa-mir-1185 Arthritis, Rheumatoid 5p may inhibit the expression of IGLL5 during the progression of RA. +transcription factor target 33604823 hsa-mir-3679 Arthritis, Rheumatoid 5p may inhibit the expression of IGLL5 during the progression of RA. +lncRNA target 33604775 hsa-mir-21 Lupus Nephritis The inhibition of the miR +genetics_knock down_suppress 33604734 hsa-mir-628 Thyroid Cancer, Papillary Knockdown of KLF12 enhanced the inhibitory effects of miR +genetics_knock down_promote 33604679 hsa-mir-1 Pulmonary Arterial Hypertension The present study aimed to determine whether the knockdown of miR1 could inhibit right ventricle (RV) remodeling and thereby control PAH in model rats. +lncRNA target 33604647 hsa-mir-223 Pneumonia Our present study indicated that LINC00707 depletion alleviated LPS-induced injury in MRC-5 cells at least partly by acting as a sponge of miR5p, highlighting a new potential therapeutic avenue for pneumonia treatment. +transcription factor target 33604643 hsa-mir-141 Pneumonia, Mycoplasma The findings in the current study highlighted the protective effects of Rhy on trophocytes during PE progression, which was associated with the inhibition of miR3p. +lncRNA target 33604641 hsa-mir-155 Prostatic Neoplasms Combined with our previous findings, we identified a series of microRNAs that could be upregulated significantly under SeNP treatment, among which miR5p acts as a key component in mediating the SeNP-inhibited migration and invasion of CaP cells, through directly targeting IkappaB kinase varepsilon and Sma- and Mad-related protein 2. +other 33604630 hsa-mir-484 Susac Syndrome Yes-associated protein isoform 1 (Yap1) and miR-484 were involved in mitochondrial fission and apoptosis, especially proapoptotic roles in SIC. +other 33604572 hsa-mir-21 Neurogenic Inflammation In aggregate, these data show that Mir21 plays a role in the progression of motor deficits and neuroinflammatory modulation in degenerative cervical myelopathy. +genetics_knock down_promote 33604541 hsa-mir-21 Glomerulonephritis, IGA Conclusions We found that intrarenal miR-21 expression is increased in patients with IgAN, modestly correlated with the severity of histologic damage, and predictive of subsequent kidney function loss. +genetics_knock down_promote 33604388 hsa-mir-769 Chronic Periodontitis CONCLUSION: MALAT1 knockdown attenuated LPS-induced PDLC injury via regulating the miR +genetics_overexpression_suppress 33603864 hsa-mir-129 Carcinoma, Hepatocellular Overexpression of miR +transcription factor target 33603862 hsa-mir-34b Retinoblastoma Collectively, the results indicated that miR-34b-5p functions as a tumor suppressor in RB via regulating the Notch signaling pathway. +target gene 33603843 hsa-mir-598 Triple Negative Breast Neoplasms MicroRNA-598 inhibits the growth of triple negative breast cancer cells by targeting JAG1. +genetics_knock down_suppress 33603842 hsa-mir-143 Instent Restenosis 3p were identified as risk factors for ISR onset (all P<0.05) and knockdown of CDKN2B-AS1 in hHCtASMCs led to inhibited cell proliferation and migration. +genetics_knock down_promote 33603840 hsa-mir-613 Squamous Cell Carcinoma of Head and Neck Suppression of miR-613 partially reversed the inhibitory effects of MIAT knockdown on the proliferation, migration and invasion of LSCC cells. +target gene 33603839 hsa-mir-1323 Diabetes, Gestational MicroRNA-1323 serves as a biomarker in gestational diabetes mellitus and aggravates high glucose-induced inhibition of trophoblast cell viability by suppressing TP53INP1. +transcription factor target 33603838 hsa-mir-489 Congenital Hypothyroidism Taken together, the findings of the present study demonstrated that miR3p inhibitor could relieve CH-induced neurological damage through regulating TPT1 expression. +exosome 33603670 hsa-mir-192 Renal Insufficiency, Chronic Small RNA sequencing revealed that 4 exosomal miRNAs (miR +genetics_overexpression_promote 33603482 hsa-mir-454 Squamous Cell Carcinoma of Head and Neck 3p could be sponged by circGDI2, and its overexpression could mitigate the suppressive effects of circGDI2 overexpression on OSCC progression. +genetics_overexpression_promote 33603481 hsa-mir-32 Triple Negative Breast Neoplasms 5p) was slowly expressed in TNBC cells and sponged by HNF1A-AS1, and its overexpression hinders TNBC cell growth. +target gene 33603475 hsa-mir-194 cervical squamous cell carcinoma LncRNA SLC16A1-AS1 Suppresses Cell Proliferation in Cervical Squamous Cell Carcinoma (CSCC) Through the miR-194/SOCS2 Axis. +target gene 33603471 hsa-mir-1244 Osteosarcoma Circ_0056285 Regulates Proliferation, Apoptosis and Glycolysis of Osteosarcoma Cells via miR-1244/TRIM44 Axis. +genetics_overexpression_promote 33603467 hsa-mir-149 Glioblastoma In cell proliferation and colony formation assay, overexpression of SLC16A1-AS1 reduced the inhibitory effects of miR-149 on GBM cell proliferation. +circRNA target 33603460 hsa-mir-769 Breast Neoplasms CONCLUSION: CircYY1 promoted glycolysis and tumor growth via increasing YY1 expression through sponging miR +target gene 33603395 hsa-mir-19a Uterine Cervical Neoplasms Baicalein Represses Cervical Cancer Cell Growth, Cell Cycle Progression and Promotes Apoptosis via Blocking AKT/mTOR Pathway by the Regulation of circHIAT1/miR-19a-3p Axis. +genetics_overexpression_promote 33603394 hsa-mir-494 Small Cell Lung Carcinoma 3p distinctly reversed these inhibitory effects of WT1-AS overexpression on the tumorigenesis and progression of NSCLC. +transcription factor target 33603377 hsa-mir-144 Depression CONCLUSION: MiR-144 played an anti-depressive role in hippocampus dysfunction by inhibiting PTP1B and activating the TrkB/BDNF signaling pathway in the hippocampus of CUMS rats. +circulation_biomarker_diagnosis_ns 33602976 hsa-mir-25 Diabetes Mellitus, Type 2 Here we show that DR is associated with higher circulating miR +circulation_biomarker_diagnosis_ns 33602976 hsa-mir-495 Diabetes Mellitus, Type 2 Here we show that DR is associated with higher circulating miR +circulation_biomarker_diagnosis_ns 33602976 hsa-mir-20b Retinal Diseases Here we show that DR is associated with higher circulating miR +circulation_biomarker_diagnosis_ns 33602976 hsa-mir-25 Retinal Diseases Here we show that DR is associated with higher circulating miR +circulation_biomarker_diagnosis_ns 33602976 hsa-mir-495 Retinal Diseases Here we show that DR is associated with higher circulating miR +circulation_biomarker_diagnosis_ns 33602976 hsa-mir-20b Diabetes Mellitus, Type 2 Here we show that DR is associated with higher circulating miR +other 33602903 hsa-mir-145 Nephritis, Interstitial In conclusion, the positive feedback loop of MEG3/miR5p/RTKN/Wnt/beta-catenin/c-MYC promotes renal IRI by activating mitophagy and inducing apoptosis, which might offer a new insight into the therapeutic methods for renal IRI in the future. +other 33602903 hsa-mir-145 Iris Diseases 5p/RTKN/Wnt/beta-catenin/c-MYC promotes renal IRI by activating mitophagy and inducing apoptosis, which might offer a new insight into the therapeutic methods for renal IRI in the future. +circulation_biomarker_diagnosis_ns 33602558 hsa-mir-34c Azoospermia, Nonobstructive Hsa-miR-34c-5p expression was significantly lower in the seminal plasma of patients with NOA than normal fertile controls. We speculate that miR-34c-5p in seminal plasma could be a potential noninvasive biomarker to diagnose patients with NOA and distinguish different pathologic types of NOA. +lncRNA target 33602031 hsa-mir-139 Esophageal Squamous Cell Carcinoma Mechanistically, lncRNA BCAR4 sponged miR3p to upregulate ELAVL1, thereby inhibiting p53/p21 pathway in ESCC cells. +lncRNA target 33601867 hsa-mir-21 Airway Inflammation MicroRNA-21 inhibitors may be a novel therapeutic target in patients with allergic asthma, especially those with airway remodelling. +lncRNA target 33601338 hsa-mir-29b Cholangiocarcinoma These findings suggest miR-29b functions as a tumor suppressor in cholangiocarcinoma by relieving DNMT3B-mediated repression of CDKN2B expression. +transcription factor target 33601221 hsa-mir-383 Pregnancy Complications MiR-383 was upregulated in RPL patients and repressed LIG4 expression through interacting with 3'UTR of LIG4 mRNA. The level of miR-383 was found negatively correlated with LIG4 protein level in trophoblasts from RPL patients. +lncRNA target 33601175 hsa-mir-497 Fibrosis Collectively, we revealed that FOXM1-facilitated lncRNA-PVT1 activates lung fibroblasts via miR +lncRNA target 33601175 hsa-mir-497 Pulmonary Fibrosis Collectively, we revealed that FOXM1-facilitated lncRNA-PVT1 activates lung fibroblasts via miR +genetics_knock down_promote 33601096 hsa-mir-21 Diabetic Foot Further knockdown and overexpression of miRNA +circulation_biomarker_diagnosis_up 33601073 hsa-mir-34a Endometriosis Serum miR-34a-5p and miR-200c had a sensitivity of 78.95 % and 100 % and a specificity of 49.12 % and 100 %, respectively, for the detection of endometriosis. +circulation_biomarker_diagnosis_up 33601073 hsa-mir-200c Endometriosis Serum miR-34a-5p and miR-200c had a sensitivity of 78.95 % and 100 % and a specificity of 49.12 % and 100 %, respectively, for the detection of endometriosis. +lncRNA target 33601054 hsa-mir-17 Carcinoma, Hepatocellular In vivo, short hairpin (sh)-MIR17HG and ACVR1 inhibitors profoundly attenuated HCC cell growth and metastasis by rectifying the imbalance of TGF-beta1/BMP-7 pathways. +genetics_knock down_suppress 33600863 hsa-mir-148a Acute Kidney Injury Finally, knockdown of Rcan2 reversed the effects of miR-148a inhibition on sepsis-induced AKI. +genetics_knock down_suppress 33600863 hsa-mir-148a Sepsis Finally, knockdown of Rcan2 reversed the effects of miR-148a inhibition on sepsis-induced AKI. +genetics_GWAS 33600825 hsa-mir-141 Carcinoma, Merkel Cell 96-182 and hypomethylation of the respective microRNA loci. +genetics_GWAS 33600825 hsa-mir-200c Carcinoma, Merkel Cell 96-182 and hypomethylation of the respective microRNA loci. +lncRNA target 33600548 hsa-mir-376a Thyroid Neoplasms Rescue experiment indicated that LINC00488 might enhance PON2 expression by sponging miR-376a-3p in thyroid cancer. CONCLUSION: Taken together, our study revealed that lncRNA LINC00488 acted as an oncogenic gene in the progression of thyroid cancer via regulating miR-376a-3p/PON2 axis, which indicated that LINC00488-miR-376a-3p-PON2 axis could serve as novel biomarkers or potential targets for the treatment of thyroid cancer. +other 33600531 hsa-mir-4484 Peri-Implantitis CONCLUSION: Considering these findings, microRNA content of saliva might be proposed as a plausible source for the early diagnosis of peri-implantitis, where miR-4484 might serve as an encouraging early diagnostic biomarker. +other 33600084 hsa-mir-218 Acute Kidney Injury An increase in urinary miR-218 predicted acute kidney injury in six different studies, suggesting it is a promising biomarker for nephrotoxin-induced acute kidney injury. +genetics_overexpression_promote 33600051 hsa-mir-29a Myocardial Reperfusion Injury Rats were injected with NRF2 or CCNT2 overexpression plasmids or miR-29a-3p agomir to explore their effects on MI/RI. +genetics_overexpression_promote 33599894 hsa-mir-200a Wilms Tumor Biological function experiments illustrated that overexpression of miR-200a reduced the viability and elevated the apoptosis of Wilm's tumor cells, while overexpression of CDC7 reversed the inhibitory impact of miR-200a on cell viability and the promoting impact of miR-200a on cell apoptosis. +other 33599490 hsa-mir-99a Breast Neoplasms The deregulation of the microRNA miR-99a-5p has been previously described as an effective biomarker of early breast cancer. +other 33598975 hsa-mir-107 Osteoporosis, Postmenopausal For example, miR-107 and miR5p increased in vehicle-treated OVX animals, whereas they decreased during teriparatide treatment. +other 33598975 hsa-mir-1 Osteoporosis, Postmenopausal For example, miR-107 and miR5p increased in vehicle-treated OVX animals, whereas they decreased during teriparatide treatment. +lncRNA target 33598946 hsa-mir-21 Prostatic Neoplasms Herein, we investigate microRNA (miR-21) suppression on the doxorubicin (DOX)-sensitisation of the DOX-resistant (PC3/DOX) cell line in prostate cancer (PCa). The findings of this paper contribute to the current understanding of the functions of miR-21 in MDR-reversing in PCa. +other 33598796 hsa-mir-21 Colorectal Neoplasms The most frequent oncogenic miRs investigated were miR-21, miR-181a, miR-182, miR-183, miR-210 and miR-224 and the hyperexpression of these miRs was associated with distant metastasis, lymph node metastasis and worse survival in patients with CRC. +other 33598796 hsa-mir-210 Colorectal Neoplasms The most frequent oncogenic miRs investigated were miR-21, miR-181a, miR-182, miR-183, miR-210 and miR-224 and the hyperexpression of these miRs was associated with distant metastasis, lymph node metastasis and worse survival in patients with CRC. +other 33598796 hsa-mir-22 Colorectal Neoplasms The most frequent oncogenic miRs investigated were miR-21, miR-181a, miR-182, miR-183, miR-210 and miR-224 and the hyperexpression of these miRs was associated with distant metastasis, lymph node metastasis and worse survival in patients with CRC. +other 33598796 hsa-mir-182 Colorectal Neoplasms The most frequent oncogenic miRs investigated were miR-21, miR-181a, miR-182, miR-183, miR-210 and miR-224 and the hyperexpression of these miRs was associated with distant metastasis, lymph node metastasis and worse survival in patients with CRC. +other 33598796 hsa-mir-181a Colorectal Neoplasms The most frequent oncogenic miRs investigated were miR-21, miR-181a, miR-182, miR-183, miR-210 and miR-224 and the hyperexpression of these miRs was associated with distant metastasis, lymph node metastasis and worse survival in patients with CRC. +other 33598796 hsa-mir-183 Colorectal Neoplasms The most frequent oncogenic miRs investigated were miR-21, miR-181a, miR-182, miR-183, miR-210 and miR-224 and the hyperexpression of these miRs was associated with distant metastasis, lymph node metastasis and worse survival in patients with CRC. +lncRNA target 33598424 hsa-mir-668 Carcinoma, Hepatocellular By performing rescue assays, we demonstrated that circ_0014717 repressed HCC progression via inhibiting BTG2 expression and sponging miR +target gene 33598394 hsa-mir-488 Osteosarcoma LncRNA SNHG16 promotes epithelial-mesenchymal transition by upregulating ITGA6 through miR-488 inhibition in osteosarcoma. +circulation_biomarker_diagnosis_up 33597993 hsa-mir-1 Acute Coronary Syndrome Aim To assess levels of circulating cardiac-specific (miR-1) and endothelial-specific (miR-126) miRNAs in the acute phase of AMI and after a follow-up period. +circulation_biomarker_diagnosis_up 33597993 hsa-mir-126 Acute Coronary Syndrome Aim To assess levels of circulating cardiac-specific (miR-1) and endothelial-specific (miR-126) miRNAs in the acute phase of AMI and after a follow-up period. +other 33597968 hsa-mir-708 Leukemia, Myeloid, Acute CDK6 was also found to be positively associated with genes identified to contribute to the development of leukemia, including CCND2, DNMT3B, SOX4, and IKZF2, as well as being negatively associated with anticancer microRNAs, including miR-187, miR-9, miR-582, miR708, and miR-362. +other 33597967 hsa-mir-1260b Stomach Neoplasms We identified three miRNAs, hsa-miR-320a, hsa-miR-1260b, and hsa-miR5p, to distinguish gastric cancer cases from non-cancer controls. +other 33597967 hsa-mir-20a Stomach Neoplasms We identified three miRNAs, hsa-miR-320a, hsa-miR-1260b, and hsa-miR5p, to distinguish gastric cancer cases from non-cancer controls. +other 33597967 hsa-mir-6515 Stomach Neoplasms We identified three miRNAs, hsa-miR-320a, hsa-miR-1260b, and hsa-miR5p, to distinguish gastric cancer cases from non-cancer controls. +lncRNA target 33597871 hsa-mir-204 Vascular Calcification In the current study, we sought to test the potential protective role of TP in the regulation of vascular calcification in a rat model and explore whether TP attenuates medial vascular calcification by upregulating miRNA-204. Conclusion: TP inhibited BMP2 and RUNX2 expression and attenuated vascular calcification via upregulating the level of miRNA-204. +other 33597871 hsa-mir-204 Ventricular Premature Complexes MiRNA-204 expression was increased in the TP-treated groups compared with VC controls and the effects of TP were reversed by the intravenous injection of miRNAinterfering lentivirus. +other 33597502 hsa-mir-20 Heart Failure Together, we demonstrated that miR-320 functioned differently in various cell types of the heart during the progression of HF. +other 33596983 hsa-mir-154 Carcinoma, Hepatocellular Importantly, rescue experiments demonstrated that the miR5p/PLAGL2 axis mediated the function of MAPKAPK5-AS1 in HCC cells. +lncRNA target 33596979 hsa-mir-34a Head and Neck Neoplasms We propose miR-34a as a potential new therapeutic approach for HNSCC. +circRNA target 33596920 hsa-mir-411 Colorectal Neoplasms Furthermore, circ_0082182 promoted the CRC progression via sponging miR-411 and miR-1205. +circRNA target 33596920 hsa-mir-1205 Colorectal Neoplasms Furthermore, circ_0082182 promoted the CRC progression via sponging miR-411 and miR-1205. +other 33596914 hsa-mir-219 Bronchopulmonary Dysplasia Previous genome-wide analysis studies in preterm infants indicate that pathways of miR 219-5p are important in infants with Bronchopulmonary Dysplasia (BPD). +lncRNA target 33596914 hsa-mir-219 Borderline Personality Disorder 5p contributes to the pathogenesis of BPD by targeting and reducing PDGFR-alpha. +lncRNA target 33596784 hsa-mir-155 Uterine Cervical Neoplasms The 2 mature miRNAs of the above 2 lncRNAs, miR-9 and miR-155, also showed similar features in cervical cancer. In summary, our study demonstrated the dysregulated lncRNAs/miRNAs, particularly LINC00925/miR-9 and MIR155HG/miR-155, regulate the development of cervical cancer by forming a interaction network with mRNAs, highlighting the importance of elucidating the underlying mechanisms of ncRNAs in cervical cancer development. +lncRNA target 33596784 hsa-mir-9 Uterine Cervical Neoplasms The 2 mature miRNAs of the above 2 lncRNAs, miR-9 and miR-155, also showed similar features in cervical cancer. In summary, our study demonstrated the dysregulated lncRNAs/miRNAs, particularly LINC00925/miR-9 and MIR155HG/miR-155, regulate the development of cervical cancer by forming a interaction network with mRNAs, highlighting the importance of elucidating the underlying mechanisms of ncRNAs in cervical cancer development. +genetics_overexpression_suppress 33596640 hsa-mir-141 Leukemia, Prolymphocytic, T-Cell We identified 35 miRNA that were aberrantly expressed in T-PLL with miR-200c/141 as the most differentially expressed cluster. Furthermore, we found that overexpression of miR-200c/141 correlated with downregulation of their targets ZEB2 and TGFbetaR3 and aberrant TGFbeta1- induced phosphorylated SMAD2 (p-SMAD2) and p-SMAD3, indicating that the TGFbeta pathway is affected in T-PLL. +genetics_overexpression_suppress 33596640 hsa-mir-200c Leukemia, Prolymphocytic, T-Cell We identified 35 miRNA that were aberrantly expressed in T-PLL with miR-200c/141 as the most differentially expressed cluster. Furthermore, we found that overexpression of miR-200c/141 correlated with downregulation of their targets ZEB2 and TGFbetaR3 and aberrant TGFbeta1- induced phosphorylated SMAD2 (p-SMAD2) and p-SMAD3, indicating that the TGFbeta pathway is affected in T-PLL. +exosome 33596145 hsa-mir-21 Acute Kidney Injury Conclusion: Urinary exosomal miRNA-21 could be a surrogate marker for scrub typhus-associated AKI diagnosis. +genetics_overexpression_promote 33595945 hsa-mir-375 Colonic Neoplasms MiR-375 could be sponged by circPPP1R12A, and its inhibitor could reverse the inhibition of circPPP1R12A silencing on CC progression. Furthermore, CTNNB1 was a target of miR-375, and its overexpression also abolished the suppression of miR-375 on CC progression. +genetics_knock down_promote 33595944 hsa-mir-513b Osteosarcoma MiR-513b-5p inhibitor or E2F5 overexpression rescued the progression inhibition of osteosarcoma by UCA1 knockdown, and UCA1 regulated E2F5 and Cyclin E expression by targeting miR-513b-5p. +exosome 33594583 hsa-mir-383 Nerve Degeneration Microglia that activated by ICH promote neurons necroptosis through secreting exosomes and transferring miR +exosome 33594583 hsa-mir-383 Cerebral Hemorrhage Microglia that activated by ICH promote neurons necroptosis through secreting exosomes and transferring miR +lncRNA target 33594315 hsa-mir-21 Spinal Cord Injuries In summary, we first discovered lncRNA-MEG regulates neuronal cell apoptosis through miR5p by targeting PDCD4 in SCI. +other 33594313 hsa-mir-543 Prostatic Neoplasms MiR-543/Numb promotes proliferation, metastasis, and stem-like cell traits of prostate cancer cells. +target gene 33594311 hsa-mir-186 Breast Neoplasms SNHG3 promotes migration, invasion, and epithelial-mesenchymal transition of breast cancer cells through the miR-186-5p/ZEB1 axis. +lncRNA target 33594306 hsa-mir-199a Triple Negative Breast Neoplasms MiR-199a-3p, mTOR, LC3 and other autophagy related proteins were detected in Taxol sensitive and Taxol resistant TNBC cell lines, which were MDA-MB-231 and MDA-MB-231/Taxol, respectively. Moreover, oral administration of FMNT and Taxol suppressed autophagy and Taxol resistance by restoring mTOR protein level to that of the parent MDA-MB-231, suggesting that miR-199a-3p can severe as a new target to overcome Taxol resistance in TNBC. +circulation_biomarker_diagnosis_up 33594304 hsa-mir-206 Bronchopulmonary Dysplasia The above results indicated that MALAT1 has the potential as a blood biomarker of neonatal BPD, and MALAT1-miR-206 axis mediates BPD process, which may be a new target for neonatal BPD treatment. +other 33594262 hsa-mir-168 Blast Crisis Previously, we reported that miR168 expression was responsive to infection by Magnaporthe oryzae, the causal agent of rice blast disease(3). However, how miR168 regulates immunity to rice blast and whether it affects rice development remains unclear. +other 33594251 hsa-mir-494 Crohn Disease Collectively, our findings uncover a miR3p-mediated cross-talk mechanism by which macrophage-induced intestinal stem cell impairment aggravates intestinal inflammation. +other 33594251 hsa-mir-494 Colonic Diseases A miR3p agomir system notably ameliorated the severity of colonic colitis in vivo. +lncRNA target 33594251 hsa-mir-494 Colitis 3p-targeted EDA2R and the ligand EDA-A2, suppressed colonic stemness and epithelial repair by inhibiting beta-catenin/c-Myc. +lncRNA target 33594062 hsa-mir-3 Ataxia Neuropathy Spectrum Thus, miR-33 in the brain contributes to maintenance of BAT thermogenesis and whole-body metabolism via enhanced sympathetic nerve tone through suppressing GABAergic inhibitory neurotransmission. +lncRNA target 33593721 hsa-mir-509 Melanoma 3p suppressed the biological function of melanoma cells through negatively regulating CTHRC1, shedding light on miR +circulation_biomarker_diagnosis_down 33593717 hsa-mir-98 Coronary Artery Disease Reduced plasma miR-98 level is possibly considered a risk factor for coronary artery disease, and agomiR-98 prevents atherosclerosis and cellular injury by targeting lectin-like oxidized low-density lipoprotein receptor-1. +circRNA target 33593390 hsa-mir-433 Adenocarcinoma of Lung Further experiments indicated that circMED13L_012 promoted malignant behavior of NSCLC tumor cells by targeting MAPK8 through modulation miR +circulation_biomarker_diagnosis_up 33593281 hsa-mir-222 Atrial Fibrillation CONCLUSIONS: Serum miR-222 was independently associated with AF in patients with DVHD. +circulation_biomarker_diagnosis_up 33593281 hsa-mir-222 Heart Valve Diseases CONCLUSIONS: Serum miR-222 was independently associated with AF in patients with DVHD. +circulation_biomarker_diagnosis_up 33593252 hsa-mir-26b Diabetic Retinopathy miR-26b-5p was up-regulated in HUVECs treated with 40 mM glucose and in the serum of patients with DR before and after treatment. CONCLUSION: Our results suggest that EVs derived from miR-26b-5p are up-regulated in the serum of patients with DR. +genetics_GWAS 33593158 hsa-mir-16 Suppuration Integration of phenotypic data with transcriptome and microbiome data of the same animals revealed genetic regulated mRNA and miRNA transcripts (SMAD3, CAV1, ENNPP6, ATP2B4, miR-148a-3p, miR-146b-5p, miR +genetics_GWAS 33593158 hsa-mir-146b Suppuration Integration of phenotypic data with transcriptome and microbiome data of the same animals revealed genetic regulated mRNA and miRNA transcripts (SMAD3, CAV1, ENNPP6, ATP2B4, miR-148a-3p, miR-146b-5p, miR +genetics_GWAS 33593158 hsa-mir-1388a Suppuration Integration of phenotypic data with transcriptome and microbiome data of the same animals revealed genetic regulated mRNA and miRNA transcripts (SMAD3, CAV1, ENNPP6, ATP2B4, miR-148a-3p, miR-146b-5p, miR +other 33593046 hsa-mir-335 Nasopharyngeal Carcinoma 5p, promotes the proliferation, migration, invasion and radioresistance of NPC cells by regulating the p21 and mTOR signaling pathways. +other 33592832 hsa-let-7c Carcinoma, Hepatocellular Four lncRNAs (including LINC01517, DDX11-AS1, LINC01136, and RP11-20J15.2) and 7 miRNAs (including miR-195, miR-199b, miR-326, miR-424, and let-7c) in the ceRNA network interacted with the upregulated gene E2F2, which was associated with the overall prognosis of patients with HCC.The 11-lncRNA signature might be useful for predicting the prognosis of patients with HCC. +other 33592729 hsa-mir-100 Stomach Neoplasms Here, a biosensor CPs/AuNP-AuE, the gold nanoparticle (AuNP)-modified Au electrode (AuE) which was coupled with DNA capture probes (CPs), was developed to detect the content of miR-100 in the sera of GC patients. +other 33592702 hsa-mir-214 Breast Neoplasms Finally, simultaneous dual-color imaging of miR-451a and miR3p in human breast cancer cells (MDA-MB-231) was realized by exploiting the P(1)&P(2)@rGO nanoprobe. +other 33592702 hsa-mir-451a Breast Neoplasms Finally, simultaneous dual-color imaging of miR-451a and miR3p in human breast cancer cells (MDA-MB-231) was realized by exploiting the P(1)&P(2)@rGO nanoprobe. +other 33592260 hsa-mir-340 Leishmaniasis This research revealed that transfection of infected macrophages with miR-340 alone or in combination with miR-27a mimic can reduce macrophage infectivity and might be introduced as a novel therapeutic agent for cutaneous leishmaniasis. +other 33592260 hsa-mir-27a Leishmaniasis This research revealed that transfection of infected macrophages with miR-340 alone or in combination with miR-27a mimic can reduce macrophage infectivity and might be introduced as a novel therapeutic agent for cutaneous leishmaniasis. +circRNA target 33591945 hsa-mir-144 Colorectal Neoplasms In conclusion, we found that increased expression of circ_0115744 could differentiate CRLM from CRC and that the newly identified circ_0115744/miR-144/EZH2 axis was involved in the progression of CRC, which might be used as a potential diagnostic and therapeutic target for patients with CRC. +circRNA target 33591461 hsa-mir-769 Uterine Cervical Neoplasms Overall, our data clearly expounded the tumor-inhibiting role of circ-PGAP3 in CC, circ-PGAP3 repressed CC tumorigenesis via regulating the miR5p/p53 axis. +genetics_overexpression_promote 33590796 hsa-mir-139 Smith-McCort Dysplasia Overexpression of miR-139 or suppression of the JAK3/STAT5 signaling pathway reversed the inflammatory effect of lncRNA NEAT1.Conclusion LncRNA NEAT1 played a pivotal role in ASMC inflammation and exerted its function through the miR-139/JAK3/STAT5 signaling network. +other 33590796 hsa-mir-139 Smooth Muscle Tumor Previous studies showed that the lncRNA NEAT1 (nuclear paraspeckle assembly transcript 1) might play an important role in the pathogenesis of asthma, but its potential mechanism in airway smooth muscle cell (ASMC) inflammation remains largely unknown and needs further investigation.Methods We performed cellular immunofluorescence to identify the features of ASMCs and detected the expression levels of lncRNA NEAT1, miR-139, TNF-alpha, IL-6, IL-8 and IL-1beta by quantitative real-time PCR (Q-PCR) and ELISA. +other 33590796 hsa-mir-139 Asthma Previous studies showed that the lncRNA NEAT1 (nuclear paraspeckle assembly transcript 1) might play an important role in the pathogenesis of asthma, but its potential mechanism in airway smooth muscle cell (ASMC) inflammation remains largely unknown and needs further investigation.Methods We performed cellular immunofluorescence to identify the features of ASMCs and detected the expression levels of lncRNA NEAT1, miR-139, TNF-alpha, IL-6, IL-8 and IL-1beta by quantitative real-time PCR (Q-PCR) and ELISA. Western blotting (WB) was used to measure the protein expression of the related genes, and bioinformatics as well as dual luciferase assays were used to validate the interaction between lncRNA NEAT1 and miR-139 and the interaction between miR-139 and the 3'-UTR of JAK3.Results The expression of lncRNA NEAT1 was increased in the ASMCs of asthma patients, but miR-139 was decreased. +genetics_GWAS 33590773 hsa-mir-1 Ataxia Neuropathy Spectrum We found that an arrhythmia-associated human single nucleotide polymorphism of miR1 (hSNP14A/G) specifically disrupts the biophysical modulation while retaining the RNA interference function. +other 33590413 hsa-mir-146a Osteoarthritis, Knee This study aimed to analyze the association between two functional variants of the miR-146a gene and primary knee OA in Mexican mestizo population. Our results show that miR-146a gene variants are not significantly associated with primary knee OA in Mexican mestizos. +lncRNA target 33590038 hsa-mir-744 Colorectal Neoplasms 5p axis plays a pivotal role in the viability, invasion, migration, and epithelial-mesenchymal transition of colorectal cancer cells. +genetics_knock down_promote 33589794 hsa-mir-135a Hypertension MiR-135a-5p knockdown in SHRs attenuated hypertension, normalized FNDC5 expressions and inhibited vascular smooth muscle proliferation, and alleviated vascular remodeling. +epigenetics 33589600 hsa-mir-143 Prostatic Neoplasms Altogether, our results suggest that SChLAP1 enhanced the proliferation, migration, and tumorigenicity of prostate cancer cells through interacting with EZH2 to recruit H2K27me3 and mediate promoter methylation modification of miR +epigenetics 33589600 hsa-mir-145 Prostatic Neoplasms Altogether, our results suggest that SChLAP1 enhanced the proliferation, migration, and tumorigenicity of prostate cancer cells through interacting with EZH2 to recruit H2K27me3 and mediate promoter methylation modification of miR +genetics_knock down_promote 33589577 hsa-mir-539 Glioma CONCLUSION: PCGEM1 knockdown suppressed glioma progression through sponging miR +exosome 33589572 hsa-mir-320d Carcinoma, Non-Small-Cell Lung Thus, we conclude that exosomal lncRNA LINC00662 promotes NSCLC progression by modulating miR-320d/E2F1 axis. +other 33588834 hsa-mir-19a Colorectal Neoplasms CONCLUSION: LINC00342 promotes CRC progression by competitively binding miR-19a-3p with NPEPL1. +genetics_overexpression_promote 33588776 hsa-mir-545 Ovarian Neoplasms Either overexpression of KDM4B or PLK1 partially blocked the inhibitory effects of miR-545 mimic on OC cell growth, especially the former one. +transcription factor target 33588742 hsa-mir-574 Diabetic Nephropathies CONCLUSION: This study demonstrated that miR-574 may play important roles in DNOP, and the therapeutic effects of kaempferol and quercetin on LWD in DNOP might be mediated by miR-574 by targeting MAPK1. +genetics_knock down_promote 33588099 hsa-mir-511 Carcinoma, Hepatocellular Downregulation of miR-511 significantly increased the cell viability, invasive and migratory capacities, and could abolish the suppressive effect of LINC01559-knockdown on these HCC cells. +lncRNA target 33588071 hsa-mir-607 Carcinoma, Hepatocellular 5p inhibit HCC by acting one common target XIAP. +lncRNA target 33588025 hsa-mir-204 Obesity In humans, long-term exposure to estradiol and leptin can alter endometrial homeostasis through the NEAT1-miR5p-Igf1 axis and favor carcinogenic pathways, which provide mechanistic insight into the obesity-associated endometrial cancer. +lncRNA target 33587353 hsa-mir-337 Pancreatic Carcinoma These outcomes expounded that miR-337 inactivated the Wnt/beta-catenin pathway to suppress the malignant behaviors of pancreatic cancer cells through targeting STAT3. +other 33587348 hsa-mir-150 Liver Neoplasms 5p/MCL1 axis, providing a promising biomarker for CML. +other 33587348 hsa-mir-150 Leukemia, Myelogenous, Chronic, BCR-ABL Positive 5p/MCL1 axis, providing a promising biomarker for CML. +other 33587339 hsa-mir-374b Diabetes Mellitus The DM group showed decreased miR-374b-5p levels compared with those in the GI group and higher concentrations than those in the NG group. +circulation_biomarker_diagnosis_ns 33586614 hsa-mir-557 Thrombocytopenia Effects of miR-557 on the numbers of platelets, megakaryocytes, and peripheral blood platelets and the expressions of CD4(+) T cells, Treg cells, TGF-beta, IL-6 and miR-557 in the ITP rats were detected by Giemsa staining, flow cytometry, ELISA and qRT-PCR. +other 33586613 hsa-mir-191 Neurotoxicity Syndromes Downregulation of miR-191 has a protective role against isoflurane-induced neurotoxicity, regulates the vitality and slows down neuronal cell apoptosis. +other 33585804 hsa-mir-155 COVID-19 SARS-CoV-2 elicited an approximately two-fold higher stimulation of the innate immune response compared to SARS-CoV in the human epithelial cell line Calu-3, including induction of miRNA-155. +target gene 33585699 hsa-mir-142 Uterine Cervical Neoplasms miR-142-5p promotes cervical cancer progression by targeting LMX1A through Wnt/β-catenin pathway. +genetics_overexpression_promote 33585479 hsa-mir-4680 Cleft Palate Overexpression of miR +exosome 33585440 hsa-mir-214 Colorectal Neoplasms Exosomal Long Non-coding RNA HOTTIP Increases Resistance of Colorectal Cancer Cells to Mitomycin via Impairing MiR-214-Mediated Degradation of KPNA3. +lncRNA target 33585208 hsa-mir-106b Uterine Cervical Neoplasms Collectively, our study implies that hsa_circ_0107593 has tumor-suppressing activity in CC by physically binding with hsa-miR-20a-5p, hsa-miR5p, and hsa-miR-106b-5p. +lncRNA target 33585208 hsa-mir-93 Uterine Cervical Neoplasms Collectively, our study implies that hsa_circ_0107593 has tumor-suppressing activity in CC by physically binding with hsa-miR-20a-5p, hsa-miR5p, and hsa-miR-106b-5p. +other 33585204 hsa-mir-607 Osteosarcoma Furthermore, the results of RNA pull-down assay and invasion assay suggested that the binding between LINC00607 and miR-607 promoted OS invasion. This work revealed that LINC00607 worked as an miR-607 sponge to upregulate E2F6 expression, which promoted tumor proliferation in OS. +circulation_biomarker_diagnosis_up 33585035 hsa-mir-1 Diabetes Mellitus, Type 2 In our previous study, it was demonstrated that the cardiac and skeletal muscle specific miR-1 and miR-133 are upregulated in the blood of patients with T2D and cardiovascular disease. +circulation_biomarker_diagnosis_up 33585035 hsa-mir-133 Diabetes Mellitus, Type 2 In our previous study, it was demonstrated that the cardiac and skeletal muscle specific miR-1 and miR-133 are upregulated in the blood of patients with T2D and cardiovascular disease. +other 33584638 hsa-mir-20a Multiple Sclerosis Also, in monocytes IL10, PDL1, and PDL2 were upregulated whereas miR-1, miR-20a, miR-28, miR-95, miR-146a, miR-335, and miR-625 were downregulated between pregnant and untreated MS patients. +other 33584638 hsa-mir-625 Multiple Sclerosis Also, in monocytes IL10, PDL1, and PDL2 were upregulated whereas miR-1, miR-20a, miR-28, miR-95, miR-146a, miR-335, and miR-625 were downregulated between pregnant and untreated MS patients. +other 33584638 hsa-mir-28 Multiple Sclerosis Also, in monocytes IL10, PDL1, and PDL2 were upregulated whereas miR-1, miR-20a, miR-28, miR-95, miR-146a, miR-335, and miR-625 were downregulated between pregnant and untreated MS patients. +other 33584638 hsa-mir-1 Multiple Sclerosis Also, in monocytes IL10, PDL1, and PDL2 were upregulated whereas miR-1, miR-20a, miR-28, miR-95, miR-146a, miR-335, and miR-625 were downregulated between pregnant and untreated MS patients. +other 33584638 hsa-mir-95 Multiple Sclerosis Also, in monocytes IL10, PDL1, and PDL2 were upregulated whereas miR-1, miR-20a, miR-28, miR-95, miR-146a, miR-335, and miR-625 were downregulated between pregnant and untreated MS patients. +other 33584638 hsa-mir-335 Multiple Sclerosis Also, in monocytes IL10, PDL1, and PDL2 were upregulated whereas miR-1, miR-20a, miR-28, miR-95, miR-146a, miR-335, and miR-625 were downregulated between pregnant and untreated MS patients. +lncRNA target 33584204 hsa-mir-20a Hypoxia-Ischemia, Brain Overall, our study revealed that HDAC9 silencing could retard ischemic brain injury through the miR-20a/Neurod1 signaling. +other 33584192 hsa-mir-125b Neuralgia We concluded that Sox11 and lncRNA Slc6a19os were novel essential genes in the pathogenesis and progression of neuropathic pain and speculated that these two genes were regulated by miR-125a-5p, miR-125b-5p, and miR5p. +other 33584192 hsa-mir-125a Neuralgia We concluded that Sox11 and lncRNA Slc6a19os were novel essential genes in the pathogenesis and progression of neuropathic pain and speculated that these two genes were regulated by miR-125a-5p, miR-125b-5p, and miR5p. +other 33584192 hsa-mir-351 Neuralgia We concluded that Sox11 and lncRNA Slc6a19os were novel essential genes in the pathogenesis and progression of neuropathic pain and speculated that these two genes were regulated by miR-125a-5p, miR-125b-5p, and miR5p. +lncRNA target 33584097 hsa-mir-543 Carcinoma, Hepatocellular CONCLUSION: The circARPP21/miR-543/LIFR axis suppresses the proliferation, invasion, and migration of hepatocellular carcinoma cells. +lncRNA target 33583602 hsa-mir-103 Polycystic Ovary Syndrome In addition, miR-103 directly targeted IRS1, which was poorly expressed in PCOS, and IRS1 silencing promoted PCOS development. +genetics_GWAS 33583336 hsa-mir-146a Endometriosis Additionally, haplotype frequency in cases compared to controls and Linkage disequilibrium (LD) between the mentioned SNPs was appraised.Conclusion: MiR-146a, miR-149 and miR-499 may have a role in the pathogenesis of endometriosis. +genetics_knock down_promote 33583218 hsa-mir-16 Carcinoma, Non-Small-Cell Lung 5p inhibitors could reverse the role of XIST knockdown on radiosensitivity in NSCLC cells. +other 33583123 hsa-mir-122 Osteosarcoma 5p/NDRG3 axis is involved in the progression of OS. +lncRNA target 33582945 hsa-mir-22 Breast Neoplasms These results reveal a novel pathway of ER suppression by Twist through miR-22 activation that could potentially promote the ER negative phenotype in breast cancers. +transcription factor target 33582657 hsa-mir-574 Cardiovascular Diseases CONCLUSION: Our study first reveals that miR-3574 could alleviate IH-induced cardiomyocyte injury by targeting Axin1, which may function as a novel and promising therapy target for OSA-associated cardiovascular diseases. +transcription factor target 33582657 hsa-mir-574 Sleep Apnea, Obstructive CONCLUSION: Our study first reveals that miR-3574 could alleviate IH-induced cardiomyocyte injury by targeting Axin1, which may function as a novel and promising therapy target for OSA-associated cardiovascular diseases. +lncRNA target 33582305 hsa-mir-130b Polycystic Ovary Syndrome CONCLUSION: MiR-130b-3p directly interacts with SMAD4 to induce KGN cell proliferation, inhibit apoptosis, suggesting that miR-130b-3p expression is positively correlated with the development of PCOS. +transcription factor target 33582182 hsa-mir-124 Adrenocortical Carcinoma L51P) was associated with adCC, and AQP5 could participate in the maintenance of lens transparency by regulating vimentin expression via miR3p.1. +transcription factor target 33582182 hsa-mir-124 Hamartoma Syndrome, Multiple L51P) was associated with adCC, and AQP5 could participate in the maintenance of lens transparency by regulating vimentin expression via miR3p.1. +circulation_biomarker_prognosis_ns 33582167 hsa-mir-149 Eclampsia In preeclampsia patients, serum 4-Hydroxyglutamate was negatively correlated with PT and APTT, positively correlated with Fib content (p < 0.001); serum miR +circulation_biomarker_prognosis_ns 33582040 hsa-mir-21 Metabolic Diseases CONCLUSIONS: Serum levels of miR-148a-5p and miR +genetics_knock down_promote 33581689 hsa-mir-15a Carcinoma, Pancreatic Ductal Rescue experiments revealed that miR-15a-5p downregulation or FGFR1 restoration rescued the effects of CERS6-AS1 knockdown on the behaviors of PDAC cells. +exosome 33581127 hsa-mir-935 Osteoporosis The current work was set to inspect the relevance of bone marrow mesenchymal stem cells (BMSCs)-derived exosomes (BMSC-exo) carrying miR-935 to osteoporotic rats. Moreover, in vivo experiments showed that in ovariectomized rats, silencing of miR-935 significantly reduced BMD, BV/TV, Tb.N, Tb.Th and increased Tb.Sp. +other 33581109 hsa-mir-9-2 Schizophrenia This unique feature between DGCR8 and pri-miR2 processing may suggest a link to the risk of schizophrenia. +circulation_biomarker_diagnosis_ns 33580997 hsa-mir-508 Syphilis SLC2A1-AS1 enriched in the cytoplasm of LUAD cells could directly bind to miR +tissue_expression_ns 33580795 hsa-mir-98 Hepatolenticular Degeneration Furthermore, we showed that mutants of SQUAMOSA PROMOTER BINDING PROTEIN-LIKE7 (SPL7), the master regulator of copper homeostasis and miR398 expression, have a higher APX6 level compared with the wild type, which further increased under copper deficiency. +other 33580779 hsa-mir-133 Non-ST Elevated Myocardial Infarction In a multivariate model, three miRNAs (miR-122, miR-133, and miR-134) were found to be associated with NSTEMI with AUCs between 0.506 and 0.656. +other 33580779 hsa-mir-122 Non-ST Elevated Myocardial Infarction In a multivariate model, three miRNAs (miR-122, miR-133, and miR-134) were found to be associated with NSTEMI with AUCs between 0.506 and 0.656. +other 33580779 hsa-mir-134 Non-ST Elevated Myocardial Infarction In a multivariate model, three miRNAs (miR-122, miR-133, and miR-134) were found to be associated with NSTEMI with AUCs between 0.506 and 0.656. +lncRNA target 33580494 hsa-mir-143 Venous Thrombosis Through its miRNA response elements to compete for miR-143 and miR-15, lncRNA-LINC00659 and UXT-AS1 regulate the expression of prothrombotic genes. +lncRNA target 33580494 hsa-mir-15 Venous Thrombosis Through its miRNA response elements to compete for miR-143 and miR-15, lncRNA-LINC00659 and UXT-AS1 regulate the expression of prothrombotic genes. +lncRNA target 33580459 hsa-mir-326 Precursor Cell Lymphoblastic Leukemia-Lymphoma lncRNA H19 and BCL-2 mRNA were chosen based on in silico studies and their interactions with miR-326. lncRNA H19 was identified as an oncogenic factor which was noticeably increased in the newly diagnosed patients (P = 0.0019, AUC = 0.84) and negatively associated with miR-326 (r = -0.6, P = 0.02). Furthermore, a negative correlation was introduced between the transcriptional levels of miR-326 and the anti-apoptotic BCL-2 gene (r = -0.6, P = 0.028). +lncRNA target 33579899 hsa-mir-18a Glioblastoma Mechanistically, miR-18a directly targeted ALOXE3 and suppressed its expression and functions in GBM cells. +exosome 33579366 hsa-mir-181a Muscular Dystrophy, Duchenne EVs released from Givi-MPC were enriched in several miRNAs related to myoangiogenesis including miR-181a, miR-17, miR-210 and miR-107, and miR-19b compared with EVs from human myoblasts. +exosome 33579366 hsa-mir-107 Muscular Dystrophy, Duchenne EVs released from Givi-MPC were enriched in several miRNAs related to myoangiogenesis including miR-181a, miR-17, miR-210 and miR-107, and miR-19b compared with EVs from human myoblasts. +exosome 33579366 hsa-mir-210 Muscular Dystrophy, Duchenne EVs released from Givi-MPC were enriched in several miRNAs related to myoangiogenesis including miR-181a, miR-17, miR-210 and miR-107, and miR-19b compared with EVs from human myoblasts. +exosome 33579366 hsa-mir-17 Muscular Dystrophy, Duchenne EVs released from Givi-MPC were enriched in several miRNAs related to myoangiogenesis including miR-181a, miR-17, miR-210 and miR-107, and miR-19b compared with EVs from human myoblasts. +exosome 33579366 hsa-mir-19b Muscular Dystrophy, Duchenne EVs released from Givi-MPC were enriched in several miRNAs related to myoangiogenesis including miR-181a, miR-17, miR-210 and miR-107, and miR-19b compared with EVs from human myoblasts. +circRNA target 33579365 hsa-mir-372 Cerebral Infarction CircTTC3, miR3p, and TLR4 may serve as potential targets for the treatment of CIR injury during stroke. +circRNA target 33579365 hsa-mir-372 Reperfusion Injury, Cerebral Ischemia CircTTC3, miR3p, and TLR4 may serve as potential targets for the treatment of CIR injury during stroke. +exosome 33579361 hsa-mir-199a Spinal Cord Injuries In an in vivo experiment, exosomal miR-199a-3p/145-5p was found to upregulate TrkA expression at the lesion site and also promote locomotor function in SCI rats. CONCLUSIONS: In summary, our study showed that exosomes transferring miR-199a-3p/145-5p into neurons in SCI rats affected TrkA ubiquitination and promoted the NGF/TrkA signaling pathway, indicating that hUC-MSC-derived exosomes may be a promising treatment strategy for SCI. +circRNA target 33579337 hsa-mir-622 Uveal melanoma Circ_0119872 may act as an oncogene in UM through a novel circ_0119872/miR-622/G3BP1 axis, activating the Wnt/beta-catenin and mTOR signalling pathways, which in turn may provide potential biomarkers and therapeutic targets for the management of UM. +target gene 33579314 hsa-mir-4497 Abortion, Habitual An increased miRNA-4497 level in the placental villus tissues associated with recurrent miscarriage may down-regulate SP1 expression. The negative regulation of SP1 by miRNA-4497 may potentially contribute to the pathogenesis of recurrent miscarriage through promotion of trophoblast apoptosis. +lncRNA target 33579282 hsa-mir-129 Glioblastoma Among them, the MIR155HG/has-miR5p/C1S axis is a potential marker and therapeutic target for glioblastoma. +lncRNA target 33579282 hsa-mir-155 Glioblastoma Among them, the MIR155HG/has-miR5p/C1S axis is a potential marker and therapeutic target for glioblastoma. +tissue_expression_down 33578572 hsa-mir-99a Squamous Cell Carcinoma of Head and Neck Compared with the expression in control tissues, the levels of hsa-miR-410-3p, hsa-miR-411-5p, hsa-miR-125b-2-3p, and hsa-miR-99a-3p were significantly lower in HNSCC. +tissue_expression_down 33578572 hsa-mir-411 Squamous Cell Carcinoma of Head and Neck Compared with the expression in control tissues, the levels of hsa-miR-410-3p, hsa-miR-411-5p, hsa-miR-125b-2-3p, and hsa-miR-99a-3p were significantly lower in HNSCC. +tissue_expression_down 33578572 hsa-mir-410 Squamous Cell Carcinoma of Head and Neck Compared with the expression in control tissues, the levels of hsa-miR-410-3p, hsa-miR-411-5p, hsa-miR-125b-2-3p, and hsa-miR-99a-3p were significantly lower in HNSCC. +tissue_expression_down 33578572 hsa-mir-125b-2 Squamous Cell Carcinoma of Head and Neck Compared with the expression in control tissues, the levels of hsa-miR-410-3p, hsa-miR-411-5p, hsa-miR-125b-2-3p, and hsa-miR-99a-3p were significantly lower in HNSCC. +circulation_biomarker_diagnosis_down 33578569 hsa-let-7f Infertility The levels of circulating let-7g-5p,7f-5p, and 7i-5p in the basal sera were significantly higher in the moderate ovarian response group than in the poor response group (P < .05). +circulation_biomarker_diagnosis_down 33578569 hsa-let-7g Infertility The levels of circulating let-7g-5p,7f-5p, and 7i-5p in the basal sera were significantly higher in the moderate ovarian response group than in the poor response group (P < .05). +circulation_biomarker_diagnosis_down 33578569 hsa-let-7i Infertility The levels of circulating let-7g-5p,7f-5p, and 7i-5p in the basal sera were significantly higher in the moderate ovarian response group than in the poor response group (P < .05). +genetics_overexpression_suppress 33578293 hsa-mir-378a Thyroid Cancer, Papillary Finally, we verified that both miR-378a-3p overexpression and WNT5A silencing effectively offset the impacts of FAM230B on PTC cell migration and invasion. +other 33578038 hsa-mir-22 Breast Neoplasms Moreover, BC cells secrete exosomal miR-22-3p that mediates tumor vessel abnormalization by inhibiting TAGLN. +target gene 33577975 hsa-mir-532 Osteoporosis Furthermore, our integrated experiments showed that lncRNA H19 caused a decrease in the expression of miR-532-3p, which was verified to target SIRT1 directly. +tissue_expression_up 33577860 hsa-mir-125a Hepacivirus Together, our data reveal that HCV infection results in the upregulation of miR-125a, which negatively regulates IFN signaling via inhibiting the expression of MAVS and TRAF6, thereby enabling the virus to evade innate antiviral immunity. +lncRNA target 33577845 hsa-mir-143 Aortic Dissection SIGNIFICANCE: Our findings revealed that lncRNA OIP5-AS1 exacerbates aorta intima, media, and adventitia injury in the development of AD through upregulating TUB via sponging miR +tissue_expression_up 33577844 hsa-mir-378b Carcinoma, Hepatocellular Up-regulated miR-378b and down-regulated TGFBR3 presented in HCC, and miR-378b targeted TGFBR3. +other 33577060 hsa-mir-132 Lung Injury OBJECTIVE: The aim of this study was to explore the effects of the expressions of micro ribonucleic acid (miR)-132 and sirtuin1 (Sirt1) on lung injury in sepsis rats, and to elucidate the regulatory relation between miR-132 and Sirt1. CONCLUSIONS: MiR-132 may cause lung injury in sepsis rats by regulating the expression of Sirt1. +other 33577060 hsa-mir-132 Sepsis OBJECTIVE: The aim of this study was to explore the effects of the expressions of micro ribonucleic acid (miR)-132 and sirtuin1 (Sirt1) on lung injury in sepsis rats, and to elucidate the regulatory relation between miR-132 and Sirt1. CONCLUSIONS: MiR-132 may cause lung injury in sepsis rats by regulating the expression of Sirt1. +lncRNA target 33577033 hsa-mir-207 Fibrosis, Renal After inhibiting miR-207 expression, their degree of renal fibrosis also reduced significantly, and the expression levels of TGF-beta1, Smad3, Smad2, alpha-SMA, BMP-7, MMP7 and MMP9 were inhibited. +genetics_overexpression_suppress 33577032 hsa-mir-433 Melanoma At last, cell reverse experiments demonstrated that the overexpression of microRNA-433 could attenuate the capacity of melanoma cells to proliferate and migrate +genetics_overexpression_suppress 33577031 hsa-mir-193a Nasopharyngeal Carcinoma In addition, overexpression of miR-193a-5p restrained cell progression of SUNE-1 cells. +target gene 33577030 hsa-mir-1225 Carcinoma, Non-Small-Cell Lung Finally, it was demonstrated that DANCR served as a miR-1225-3p sponge to promote ErbB2 expression and to facilitate ErbB2-mediated migration and invasion in NSCLC cells. +lncRNA target 33577029 hsa-mir-424 Colorectal Neoplasms LINC00641 could competitively bind miRNA-424-5p, thereby abolishing its inhibitory effect on PLSCR4 expression. +genetics_knock down_suppress 33577022 hsa-mir-143 Osteosarcoma Finally, it was found that the expression level of miR-143 was distinctly elevated in drug-resistant human osteosarcoma cells after knockdown of FOXD2-AS1 (p<0.05). +genetics_knock down_promote 33577018 hsa-mir-29c Osteoporosis, Diabetic CONCLUSIONS: MiR-29c-3p reduces bone loss in rats with DOP via targeted regulation of Dvl2 expression. +other 33577015 hsa-mir-125b Spondylarthropathies When compared to the control group, 6 miRNAs (miR-125b-5p, miR3p, miR-19a-3p, miR-20a-5p, miR-29c-3p, miR-30b-5p) were detected to be upregulated, and 42 miRNAs were detected to be downregulated in the rad-AxSpA group. +other 33577015 hsa-mir-19a Spondylarthropathies When compared to the control group, 6 miRNAs (miR-125b-5p, miR3p, miR-19a-3p, miR-20a-5p, miR-29c-3p, miR-30b-5p) were detected to be upregulated, and 42 miRNAs were detected to be downregulated in the rad-AxSpA group. +other 33577015 hsa-mir-144 Spondylarthropathies When compared to the control group, 6 miRNAs (miR-125b-5p, miR3p, miR-19a-3p, miR-20a-5p, miR-29c-3p, miR-30b-5p) were detected to be upregulated, and 42 miRNAs were detected to be downregulated in the rad-AxSpA group. +other 33577015 hsa-mir-29c Spondylarthropathies When compared to the control group, 6 miRNAs (miR-125b-5p, miR3p, miR-19a-3p, miR-20a-5p, miR-29c-3p, miR-30b-5p) were detected to be upregulated, and 42 miRNAs were detected to be downregulated in the rad-AxSpA group. +genetics_knock down_promote 33576470 hsa-mir-25 Osteoarthritis 3p overexpression or IGFBP7 knockdown. +genetics_knock down_suppress 33576462 hsa-mir-138 Heart Failure y contrast, knockdown of miR1385p in the in vitro HF models significantly protected the cardiomyocytes. +genetics_knock down_promote 33576461 hsa-mir-150 Dementia, Vascular Therefore, the present study indicated that miR150 knockdown ameliorated VD symptoms by upregulating HOXA1 expression in vivo and in vitro. +lncRNA target 33576460 hsa-mir-454 Nasopharyngeal Carcinoma Moreover, miR454 was identified as a target of KCNQ1OT1. Furthermore, the results indicated that miR454 directly targeted USP47. +target gene 33576457 hsa-mir-28 Uterine Cervical Neoplasms LINC01006 was verified as an endogenous 'sponge' that competed for microRNA285p (miR285p), which resulted in the upregulation of the miR285p target P21activated kinase 2 (PAK2). +target gene 33576456 hsa-mir-20a Acute Kidney Injury The results also indicated that PVT1 served as a sponge of miR20a5p, and miR20a5p directly targeted NLRP3. +lncRNA target 33576454 hsa-mir-2278 Ovarian Neoplasms In addition, the data demonstrated that large tumor suppressor 2 (LATS2) was a target gene of miR2278, whose expression was upregulated by ASAP1IT1 in ovarian cancer cells. +tissue_expression_down 33576453 hsa-mir-106a Periodontal Diseases By contrast, miR106a5p expression was downregulated in OMincubated hPDLSCs compared with GMincubated hPDLSCs. +tissue_expression_up 33576452 hsa-mir-592 Colorectal Neoplasms It was found that miR592 expression was significantly elevated in CRC tissues and cell lines, and was associated with the prognosis of patients. +circRNA target 33576448 hsa-mir-20a Atherosclerosis On the whole, the present study demonstrates that, circUSP36 regulates oxLDLinduced HUVEC injury and inflammation by modulating ROCK2 via competitively targeting miR20a5p. +genetics_overexpression_promote 33576445 hsa-mir-141 Necrobiotic Disorders Furthermore, the rate of TUNEL positive cells, and GSDMDN and pyroptosisassociated protein expression levels were significantly reduced by miR1413p overexpression in MALAT1overexpression H9C2 cells. +target gene 33576006 hsa-mir-203 Breast Neoplasms Our findings displayed significant decrease in PRKCQ mRNA level and luciferase signals in cells with restored miR-203 expression, therefore, validated PRKCQ as a direct target of miR-203. +other 33575477 hsa-mir-130b Lung Neoplasms microRNA-130b-3p Contained in MSC-Derived EVs Promotes Lung Cancer Progression by Regulating the FOXO3/NFE2L2/TXNRD1 Axis. +genetics_GWAS 33575257 hsa-mir-15 Depression, Post Stroke "Combining literature mining and network analysis, our results proposed an underlying mechanism of ""miRSNP --> miRNA --> risk gene --> pathway"" axis effects on PSD pathogenesis, especially for rs28457673 (miR-15/16/195/424/497 family) --> IGF1R --> hsa04010 (MAPK signaling pathway)." +lncRNA target 33575204 hsa-mir-128 Melanoma 3p was expressed in low levels in these MM cells and may serve as a tumor suppressor by inhibiting proliferation, migration, and invasion, as well as inducing apoptosis in these MM cells. +other 33575116 hsa-mir-100 Carcinoma, Hepatocellular The DLEU2L-hsa-miR5p/ hsa-miR-99a-5p-TAOK1 ceRNA network related to the prognosis of HCC was obtained by performing bioinformatics analysis. +other 33575116 hsa-mir-99a Carcinoma, Hepatocellular The DLEU2L-hsa-miR5p/ hsa-miR-99a-5p-TAOK1 ceRNA network related to the prognosis of HCC was obtained by performing bioinformatics analysis. +lncRNA target 33575111 hsa-mir-351 Alzheimer Disease 5p/Miro2 axis as critical in hippocampal neural progenitor cell death, and a potential therapeutic target in AD. +target gene 33575082 hsa-mir-34a Liver Neoplasms Elevated HMGB1 expression induced by hepatitis B virus X protein promotes epithelial-mesenchymal transition and angiogenesis through STAT3/miR-34a/NF-κB in primary liver cancer. +transcription factor target 33574984 hsa-mir-152 Cardiotoxicity These results suggest that miR-152 may be a promising therapeutic target for the treatment of DOX-induced cardiotoxicity. +genetics_knock down_promote 33574939 hsa-mir-182 Gallbladder Neoplasms knockdown attenuated epithelial-mesenchymal transition (EMT) in GBC cells, as indicated by decreased cell migratory and invasive abilities, decreased vimentin expression, and increased E-cadherin expression. +genetics_overexpression_suppress 33574932 hsa-mir-3171 Colorectal Neoplasms Long non-coding RNA OTUD6B-AS1 overexpression inhibits the proliferation, invasion and migration of colorectal cancer cells via downregulation of microRNA-3171. +lncRNA target 33574830 hsa-mir-129 non-alcoholic steatohepatitis Thus, NEAT1-targeted inhibition against miR +other 33574820 hsa-mir-223 Lupus Nephritis CONCLUSION: Unexpectedly, the deletion of Mir223 exacerbated the lupus phenotypes associated with increased population of S1PR1(+)CD4(+) T in spleen and the enhanced infiltration of S1PR1(+)CD4(+) T cells in inflamed kidney tissues, suggesting compensatory role of Mir223 in the pathogenesis of lupus nephritis. +lncRNA target 33574708 hsa-mir-551b Breast Neoplasms LINC00665 could affect BC progression via regulating miR-551b-5p. DISCUSSION: Taken together, our study showed that the LINC00665/miR-551b-5p axis was involved in the progression of BC. +lncRNA target 33574707 hsa-mir-223 Carcinoma, Hepatocellular Furthermore, celastrol exerted the anti-HCC effect in vitro through the miR +lncRNA target 33574704 hsa-mir-4270 Retinoblastoma CONCLUSION: Altogether, our findings demonstrated that ELFN1-AS1 promotes retinoblastoma progression through mediating miR-4270/SBK1 axis and might be a promising therapeutic target. +genetics_knock down_suppress 33574702 hsa-mir-623 Carcinoma, Non-Small-Cell Lung miR-623 knockdown or FOXM1 overexpression mitigated the role of circZNF609 silence in NSCLC development. CONCLUSION: circZNF609 knockdown repressed NSCLC development via regulating miR-623 and FOXM1. +exosome 33574696 hsa-mir-127 Osteoarthritis CONCLUSION: This study suggests that exosomal miR +genetics_GWAS 33574092 hsa-mir-181a Ovarian Neoplasms Overall, our results demonstrate that miR-181a is a nonmutational activator of Wnt signaling that drives stemness and chemoresistance in HGSOC, suggesting that the miR-181a-SFRP4 axis can be evaluated as a novel biomarker for beta-catenin-targeted therapy in this disease. +lncRNA target 33573388 hsa-mir-219 Endometrial Neoplasms We discovered LINC00461 could sponge microRNA-219-5p (miR-219-5p) and suppress its expression, thereby upregulating expression level of miR-219-5p's target, cyclooxygenase-2 (COX-2). +other 33573274 hsa-mir-221 Pancreatic Carcinoma Effects were assessed on changes in EV signatures, including EV microRNA cargo (miR-21, miR-126, and miR-221), on changes in cellular protein expression relevant for pancreatic cancer progression and invasion (moesin), for mitochondrial housekeeping (prohibitin, PHB), and gene regulation (deiminated histone H3, citH3). +other 33573274 hsa-mir-21 Pancreatic Carcinoma Effects were assessed on changes in EV signatures, including EV microRNA cargo (miR-21, miR-126, and miR-221), on changes in cellular protein expression relevant for pancreatic cancer progression and invasion (moesin), for mitochondrial housekeeping (prohibitin, PHB), and gene regulation (deiminated histone H3, citH3). +other 33573274 hsa-mir-126 Pancreatic Carcinoma Effects were assessed on changes in EV signatures, including EV microRNA cargo (miR-21, miR-126, and miR-221), on changes in cellular protein expression relevant for pancreatic cancer progression and invasion (moesin), for mitochondrial housekeeping (prohibitin, PHB), and gene regulation (deiminated histone H3, citH3). +other 33573268 hsa-mir-139 Scleroderma, Systemic 5p expression in SSc patients and induced by TLR9 stimulation in healthy pDCs. +target gene 33572976 hsa-mir-143 ovarian carcinoma On the mechanistic side, we demonstrate that HER2 knockdown or inhibition reduces miR-143 levels with subsequent de-repression of HER3 expression, and validates HER3 as a direct target of miR-143. +circulation_biomarker_diagnosis_down 33572759 hsa-mir-590 Metabolic Syndrome A lower mir-590 and mir-let7a, and a higher mir-192 level, were found in patients who met the high-density lipoprotein cholesterol (HDL) criterion of MS. +circulation_biomarker_diagnosis_down 33572759 hsa-let-7a Metabolic Syndrome A lower mir-590 and mir-let7a, and a higher mir-192 level, were found in patients who met the high-density lipoprotein cholesterol (HDL) criterion of MS. +circulation_biomarker_diagnosis_up 33572759 hsa-mir-192 Metabolic Syndrome A lower mir-590 and mir-let7a, and a higher mir-192 level, were found in patients who met the high-density lipoprotein cholesterol (HDL) criterion of MS. +other 33572343 hsa-mir-7704 Lung Neoplasms Besides, a distinctive miRNA profile between LC adenocarcinoma and squamous cell carcinoma was observed, where a combined panel of miR3p, miR-8075 and miR-7704 enabling discrimination between them. +other 33572343 hsa-mir-8075 Lung Neoplasms Besides, a distinctive miRNA profile between LC adenocarcinoma and squamous cell carcinoma was observed, where a combined panel of miR3p, miR-8075 and miR-7704 enabling discrimination between them. +other 33572343 hsa-mir-4529 Lung Neoplasms Besides, a distinctive miRNA profile between LC adenocarcinoma and squamous cell carcinoma was observed, where a combined panel of miR3p, miR-8075 and miR-7704 enabling discrimination between them. +tissue_expression_up 33572275 hsa-mir-126 Fabry Disease We observed that FD patients are characterized by higher miR-126-3p levels in sEVs, compared to age-matched healthy subjects. +target gene 33572255 hsa-mir-106a Colorectal Neoplasms Moreover, we confirm that ULK1 is a bona fide target of hsa-miR-106a-5p (referred to from here on as miR-106a) in HCT116. +lncRNA target 33572095 hsa-mir-146b Diabetes Mellitus, Type 2 LncRNA SRA contributed to T1D pathogenesis through the inhibition of miR-146b in beta-cells, with activating signaling transduction of interleukin-1 receptor-associated kinase 1 (IRAK1)/LDHA/pLDHA. +other 33572085 hsa-mir-16 Leukemia, Erythroblastic, Acute miR-16-5p Promotes Erythroid Maturation of Erythroleukemia Cells by Regulating Ribosome Biogenesis. +circulation_biomarker_diagnosis_ns 33571679 hsa-mir-106b Colorectal Neoplasms Clinically, miR-106b was significantly elevated in CRC tissues and negatively correlated with the levels of PDCD4 in CRC specimens, and high expression of exosomal miR-106b in plasma was significantly associated with the malignant progression of CRC. +tissue_expression_down 33571628 hsa-mir-1185-1 Schizophrenia We identified four differentially expressed miRNAs (miR-337-3p, miR-127-5p, miR-206, miR-1185-1-3p) in SCZ astrocytes that exhibited significantly lower baseline expression relative to CTRLs. +tissue_expression_down 33571628 hsa-mir-127 Schizophrenia We identified four differentially expressed miRNAs (miR-337-3p, miR-127-5p, miR-206, miR-1185-1-3p) in SCZ astrocytes that exhibited significantly lower baseline expression relative to CTRLs. +tissue_expression_down 33571628 hsa-mir-337 Schizophrenia We identified four differentially expressed miRNAs (miR-337-3p, miR-127-5p, miR-206, miR-1185-1-3p) in SCZ astrocytes that exhibited significantly lower baseline expression relative to CTRLs. +tissue_expression_down 33571628 hsa-mir-206 Schizophrenia We identified four differentially expressed miRNAs (miR-337-3p, miR-127-5p, miR-206, miR-1185-1-3p) in SCZ astrocytes that exhibited significantly lower baseline expression relative to CTRLs. +exosome 33571516 hsa-mir-29a Cardiomyopathies SIGNIFICANCE: These findings support the cardioprotective action of miR-29a-3p transmitted by MSCs-derived EVs in SAP-induced myocardial injury via downregulation of the HMGB1/TLR4/Akt axis, highlighting a promising target for the EV-based therapy for SAP. +exosome 33571516 hsa-mir-29a Pancreatitis SIGNIFICANCE: These findings support the cardioprotective action of miR-29a-3p transmitted by MSCs-derived EVs in SAP-induced myocardial injury via downregulation of the HMGB1/TLR4/Akt axis, highlighting a promising target for the EV-based therapy for SAP. +target gene 33571038 hsa-mir-377 Squamous Cell Carcinoma of Head and Neck Interestingly, LDHA was identified to be a target of miR-377-3p, and FTH1P3 promoted LDHA expression by suppressing miR-377-3p. +circRNA target 33571015 hsa-mir-106a Glioma Moreover, miR-106a-5p was found serving as a target of circ-ITCH and miR-106a-5p mimics could reverse the inhibitory effect of circ-ITCH on glioma cell proliferation and invasion. +genetics_knock down_promote 33570734 hsa-mir-101 Carcinoma, Non-Small-Cell Lung Exosomal circ_PIP5K1A knockdown inhibited NSCLC progression and promoted cisplatin sensitivity by regulating miR-101/ABCC1 axis, providing a novel avenue for treatment of NSCLC. +target gene 33570696 hsa-mir-27a Neurofibromatosis 1 Intriguingly, NF1 was revealed to be the target of both miR-27a-3p and miR-27b-3p, and was negatively modulated by them. +target gene 33570696 hsa-mir-27b Neurofibromatosis 1 Intriguingly, NF1 was revealed to be the target of both miR-27a-3p and miR-27b-3p, and was negatively modulated by them. +lncRNA target 33570683 hsa-mir-760 Congenital contractural arachnodactyly Mechanistically, FOXD2-AS1 was founded to interact directly with miR-760 and the oncogene E2F3 was the downstream target of miR-760 through bioinformatic prediction and dual-luciferase reporter assays. +lncRNA target 33570445 hsa-mir-512 Colorectal Neoplasms n conclusion, LINC00997 regulated the metastasis of CRC by targeting miR-512-3p, providing some insights into the regulatory mechanism of CRC. +tissue_expression_up 33570434 hsa-mir-524 Melanoma Additionally, IVM was found to have significant potential in regulating MM-related miRNAs, upregulating miR-579 and miR-524, and downregulating miR-191 and miR-193, in MM cells (p < 0.05, p < 0.01). +tissue_expression_up 33570434 hsa-mir-579 Melanoma Additionally, IVM was found to have significant potential in regulating MM-related miRNAs, upregulating miR-579 and miR-524, and downregulating miR-191 and miR-193, in MM cells (p < 0.05, p < 0.01). +tissue_expression_down 33570434 hsa-mir-191 Melanoma Additionally, IVM was found to have significant potential in regulating MM-related miRNAs, upregulating miR-579 and miR-524, and downregulating miR-191 and miR-193, in MM cells (p < 0.05, p < 0.01). +tissue_expression_down 33570434 hsa-mir-193 Melanoma Additionally, IVM was found to have significant potential in regulating MM-related miRNAs, upregulating miR-579 and miR-524, and downregulating miR-191 and miR-193, in MM cells (p < 0.05, p < 0.01). +lncRNA target 33570057 hsa-mir-148a Carcinoma, Hepatocellular Here, we demonstrated that rhamnetin decelerated elimination of the molecular-targeting agent sorafenib in HCC cells via the microRNA (miR)-148a/PXR axis. +transcription factor target 33569850 hsa-mir-21 Inflammatory Bowel Diseases Moreover, we confirmed that miR-21a-5p was mainly derived from M1 macrophages and demonstrated that KLRG1, a surface inhibitory receptor on ILC2s, participated in excessive ILC2 activation in UC by promoting GATA-3. +genetics_overexpression_suppress 33569751 hsa-mir-143 Uterine Cervical Neoplasms Our results showed that miRNA-143 overexpression could increase cisplatin-induced apoptosis and increase the sensitivity of CaSki cells to low doses of this chemotherapeutic agent via modulating the expression of apoptosis-related genes including Bcl-2, Bax, and caspase-9. +lncRNA target 33569470 hsa-mir-291b Brain Ischemia 60 min before MCAO, mimics and inhibitor of miR-291b were injected into the right lateral ventricle respectively, then the infarct volume and neuronal apoptosis were analyzed. Among the differentially expressed miRNAs, miR-291b was selected to assess the effects of mild therapeutic hypothermia in MCAO rats. +lncRNA target 33569463 hsa-mir-124 Pelvic Floor Disorders 3p could accelerate myogenic differentiation of ADSCs by down-regulating Cav1 to improve PFD in SD rats, which will pave the way for therapeutic delivery of miRNA targeting PFD disease. +genetics_overexpression_promote 33569456 hsa-mir-129 Cardiomegaly CONCLUSIONS: In general, the results indicate that the overexpression of miRNA +other 33569453 hsa-mir-365 Intervertebral Disc Displacement RESULTS: The gene expressions of MT1DP and miR-365 in human degenerative disc NP tissues and nucleus pulposus cells (NPCs) were significantly increased, while the level of NRF-2 was significantly decreased. +other 33569440 hsa-mir-145 Adenocarcinoma of Lung RESULTS: Based on the GEO database and tissue sample from our institution, we identified that the circRNA circ_104640, the miR5p, and CCL20 (C-C motif chemokine ligand 20) were abnormally expressed in the tissues of early-stage LUAC. +circulation_biomarker_prognosis_up 33569439 hsa-mir-155 Liver Cirrhosis Methods Exosomal miR-155 quantity was analyzed by sampling serum exosomes of patients with hepatic fibrosis and a hepatic fibrosis rat model. +target gene 33569427 hsa-mir-29c Uterine Cervical Neoplasms MiR-29c-3p inhibits epithelial-mesenchymal transition to inhibit the proliferation, invasion and metastasis of cervical cancer cells by targeting SPARC. +target gene 33569426 hsa-mir-377 Ovarian Neoplasms MicroRNA-377-3p targeting MMP-16 inhibits ovarian cancer cell growth, invasion, and interstitial transition. +lncRNA target 33569425 hsa-mir-383 Nasopharyngeal Carcinoma 5p targeted the 3'UTR of RBM3 and contributed to the efficacy of NPC radiation therapy by altering the RBM3-mediated JNK and ERK signaling pathways. +lncRNA target 33569424 hsa-mir-34a Heart Arrest CONCLUSIONS: LncRNA MEG3 can protect the intestinal barrier from cardiac arrest-induced I/R injury via miR-34a-3p/SIRT1/NF-kappaB signaling. +lncRNA target 33569424 hsa-mir-34a Reperfusion Injury CONCLUSIONS: LncRNA MEG3 can protect the intestinal barrier from cardiac arrest-induced I/R injury via miR-34a-3p/SIRT1/NF-kappaB signaling. +other 33569416 hsa-mir-21 Colorectal Neoplasms 5-FU treatment upregulated miR-21, which directly repressed PDCD4, and subsequently activated the JNK pathway, leading to the upregulation of ABCG2 in CRC cells. +lncRNA target 33569351 hsa-mir-4319 Nasopharyngeal Carcinoma Further investigations illustrated that miR-4319 had low expression in NPC cells and functioned as a tumor suppressor in the progression of NPC. +genetics_overexpression_promote 33569293 hsa-mir-140 Adenocarcinoma of Lung Additionally, the overexpression of circ-AASDH could deduce the suppression of miR +other 33569005 hsa-mir-196a Hypertension, Pulmonary We confirmed by RT-qPCR that the levels of miR-196a-5p were increased more than nine-fold in CD26(+) (BCR-ABL1 (+) ) vs. CD26(-) (BCR-ABL1 (-)) CD34(+)CD38(-) fractions from CML-CP patients at diagnosis, and in silico analysis revealed a significant association to lipid metabolism and hematopoiesis functions. +lncRNA target 33568918 hsa-mir-133a Squamous Cell Carcinoma of Head and Neck CONCLUSION: Our study elucidated a new mechanism of lncRNA FER1L4 that promoting OSCC progression by directly targeting miR-133a-5p/Prx1 axis and provided novel therapeutic targets for OSCC. +lncRNA target 33568915 hsa-mir-650 Endometrial Neoplasms CONCLUSION: Taken together, these data suggested that lncRNA MCTP1-AS1 inhibited cell proliferation, migration, invasion and EMT process of EC cells via targeting the miR-650/SMAD7 axis and it has the potential to be explored as a therapeutic target for the treatment of EC in the future. +other 33568625 hsa-mir-200a Urinary Bladder Neoplasms Furthermore, we found that STMN1 is involved in circST6GALNAC6/miR-200a-3p axis-regulated BCa EMT and metastasis. Thus, our findings indicate an important underlying mechanism in BCa metastasis by which SP1-induced circST6GALNAC6 sponges miR-200a-3p to promote STMN1/EMT signalling. +genetics_knock down_promote 33567852 hsa-mir-204 Stomach Neoplasms Knockdown of lncRNA SNHG4 suppresses gastric cancer cell proliferation and metastasis by targeting miR-204-5p. +circulation_biomarker_diagnosis_ns 33566451 hsa-mir-467 Hyperglycemia We investigated the role of miR-467a-5p, a miRNA induced by hyperglycaemia, in regulating inflammation and blood glucose handling. We previously demonstrated that miR-467a-5p is induced by hyperglycaemia and inhibits the production of thrombospondin-1 (TSP-1), a protein implicated in regulating inflammation. +circulation_biomarker_diagnosis_ns 33566451 hsa-mir-467a Hyperglycemia We investigated the role of miR-467a-5p, a miRNA induced by hyperglycaemia, in regulating inflammation and blood glucose handling. We previously demonstrated that miR-467a-5p is induced by hyperglycaemia and inhibits the production of thrombospondin-1 (TSP-1), a protein implicated in regulating inflammation. +circulation_biomarker_diagnosis_ns 33566451 hsa-mir-467a Insulin Resistance miR-467a-5p provides a physiological feedback when blood glucose is elevated to avoid inflammation and increased blood glucose and insulin levels, which may prevent IR. +circulation_biomarker_diagnosis_ns 33566451 hsa-mir-467 Insulin Resistance miR-467a-5p provides a physiological feedback when blood glucose is elevated to avoid inflammation and increased blood glucose and insulin levels, which may prevent IR. +genetics_overexpression_promote 33566449 hsa-mir-204 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Moreover, overexpression of miR-204 inhibited T-ALL cell proliferation while enhancing their apoptosis through interleukin receptor-associated kinase 1 (IRAK1), which enhanced the expression of matrix metalloproteinase-2 (MMP-2) and MMP-9 through activation of p-p65. +genetics_overexpression_suppress 33566299 hsa-mir-122 Neuralgia We also found that overexpressing miR +lncRNA target 33566259 hsa-mir-599 Atherosclerosis Besides, miR-599 was verified to be a direct downstream target of XIST and miR-599 inhibitor reversed the effects of XIST knockdown on AS progression. +other 33566257 hsa-mir-147 Inflammation Taken together, our data show the successful development of a transgenic animal model for tissue and cell-specific deletion of miR-147 that can be used to study the functional roles of miR-147 during inflammatory organ injury. +genetics_knock down_promote 33566202 hsa-mir-124 Depression Knockdown of NPY abolished the protective effects of inhibited miR +other 33565802 hsa-mir-204 Autoimmune polyendocrinopathy syndrome, type 1 5p expression was profoundly reduced in cerulein-induced AP model. +other 33565802 hsa-mir-204 Pancreatitis, Acute Necrotizing OBJECTIVE: This research plans to address the function of miR5p/tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma (YWHAG) in cerulein-induced acute pancreatitis (AP). +tissue_expression_down 33565800 hsa-mir-143 Pancreatic Neoplasms PVT1 was upregulated while miR-143 was downregulated in pancreatic cancer. +genetics_overexpression_promote 33565716 hsa-mir-138 Carcinoma, Hepatocellular 5p mmics inhibited the activation of AKT and mTOR in HepG2/OXA and SMMC-7721/OXA cells, whereas UCA1 overexpression increased the phosphorylated AKT and mTOR levels in parental counterparts. +target gene 33565360 hsa-mir-7 Pulmonary Arterial Hypertension Downstream of the QKI-miR-7 axis, the serine and arginine-rich splicing factor 1 (SRSF1) was identified as a direct target of miR-7. +circulation_biomarker_diagnosis_ns 33565328 hsa-mir-125b Coronary Disease Materials & methods: A total of 274 CHD patients undergoing DES-PCI were enrolled, pre-operative plasma samples were obtained to detect lnc-MALAT1, miR-125b, miR-146a, miR-203 by RT-qPCR; 2-year restenosis was determined by quantitative coronary angiography. +circulation_biomarker_diagnosis_ns 33565328 hsa-mir-203 Coronary Disease Materials & methods: A total of 274 CHD patients undergoing DES-PCI were enrolled, pre-operative plasma samples were obtained to detect lnc-MALAT1, miR-125b, miR-146a, miR-203 by RT-qPCR; 2-year restenosis was determined by quantitative coronary angiography. +circulation_biomarker_diagnosis_ns 33565328 hsa-mir-146a Coronary Disease Materials & methods: A total of 274 CHD patients undergoing DES-PCI were enrolled, pre-operative plasma samples were obtained to detect lnc-MALAT1, miR-125b, miR-146a, miR-203 by RT-qPCR; 2-year restenosis was determined by quantitative coronary angiography. +tissue_expression_up 33565325 hsa-mir-452 Carcinoma, Hepatocellular Results: MiR-452-5p was greatly upregulated in HCC cells, and it served as an oncogene playing an active role in HCC cell proliferation, migration and invasion. +tissue_expression_up 33565089 hsa-mir-181 Diabetes Mellitus, Type 1 Seven microRNAs demonstrated contrasting expression between the two groups, with two of them showing significant overexpression in T1DM group (miR-181:95% CI: 0.429 to 1.341 P < .001, miR-210:95% CI: 0.381 to 0.852, P < .001) and one micro-RNA being significantly overexpressed in control group (miR-375:95% CI: 0.293 to 1.459, P = .003). +tissue_expression_up 33565089 hsa-mir-210 Diabetes Mellitus, Type 1 Seven microRNAs demonstrated contrasting expression between the two groups, with two of them showing significant overexpression in T1DM group (miR-181:95% CI: 0.429 to 1.341 P < .001, miR-210:95% CI: 0.381 to 0.852, P < .001) and one micro-RNA being significantly overexpressed in control group (miR-375:95% CI: 0.293 to 1.459, P = .003). +tissue_expression_down 33565089 hsa-mir-375 Diabetes Mellitus, Type 1 Seven microRNAs demonstrated contrasting expression between the two groups, with two of them showing significant overexpression in T1DM group (miR-181:95% CI: 0.429 to 1.341 P < .001, miR-210:95% CI: 0.381 to 0.852, P < .001) and one micro-RNA being significantly overexpressed in control group (miR-375:95% CI: 0.293 to 1.459, P = .003). +target gene 33564997 hsa-mir-23b Osteoporosis MiR-23b-3p functioned as an O-positive factor through regulating cell cycle, proliferation, apoptosis, and differentiation via targeting CCND1. +lncRNA target 33564933 hsa-mir-222 Enterocolitis, Necrotizing CONCLUSION: Macrophages activation in NEC intestine results in an increased inflammatory response and TNF-alpha production, accompanied with miR-222 upregulation and c-kit suppression. Modulations of M1 macrophages, TNF-alpha or miR-222 may be potential therapeutic targets for NEC treatment. +target gene 33564883 hsa-mir-483 Diabetes Mellitus, Type 2 Moreover, Aldh1a3 was validated as a direct target of miR-483 and overexpression of miR-483 repressed Aldh1a3 expression. +lncRNA target 33564439 hsa-mir-99a Diabetic Nephropathies miR-99a-5p was upregulated in macroalbuminuric patients compared with normoalbuminuric and microalbuminuric patients. miR-99a-5p expression is elevated in EVs from macroalbuminuria and mTOR is its validated mRNA target. +lncRNA target 33564344 hsa-mir-31 Colorectal Neoplasms he findings reveal for the first time that linc01184 is an enhancer for the proliferation and invasion of CRC by functioning as a ceRNA through the linc01184-miR-331-HER2-p-Akt/ERK1/2 pathway regulatory network. +genetics_overexpression_promote 33564307 hsa-mir-1290 Carcinoma, Hepatocellular In this study, our miRNome sequencing demonstrated that miR-1290 was overexpressed in HCC patient serum-derived exosomes, and we found that delivery of miR-1290 into human endothelial cells enhanced their angiogenic ability. Collectively, our findings provide evidence that miR-1290 is overexpressed in HCC and promotes tumor angiogenesis via exosomal secretion, implicating its potential role as a therapeutic target for HCC. +target gene 33564285 hsa-mir-612 Pancreatic Neoplasms Simultaneous microRNA-612 restoration and 5-FU treatment inhibit the growth and migration of human PANC-1 pancreatic cancer cells. +genetics_overexpression_promote 33564267 hsa-mir-152 Melanoma 3p and overexpression of HOXA11-AS mitigated the miR +target gene 33564265 hsa-mir-212 Stomach Neoplasms Upregulation of Linc-ROR Promotes the Proliferation, Migration, and Invasion of Gastric Cancer Cells Through miR-212-3p/FGF7 Axis. +exosome 33564242 hsa-mir-143 Osteosarcoma Bone Marrow Mesenchymal Stem Cells-Derived Extracellular Vesicles Promote Proliferation, Invasion and Migration of Osteosarcoma Cells via the lncRNA MALAT1/miR-143/NRSN2/Wnt/β-Catenin Axis. +transcription factor target 33563844 hsa-mir-132 Duane Retraction Syndrome These are the first data to suggest that miR-132 may contribute to the progression of diabetic retinopathy (DR) and that targeting the effect of miR-132 on occudin and the JAK/STAT3 pathway could represent a novel effective DR-treatment strategy. +transcription factor target 33563844 hsa-mir-132 Diabetic Retinopathy These are the first data to suggest that miR-132 may contribute to the progression of diabetic retinopathy (DR) and that targeting the effect of miR-132 on occudin and the JAK/STAT3 pathway could represent a novel effective DR-treatment strategy. +circulation_biomarker_diagnosis_up 33563583 hsa-mir-129 Carcinoma, Hepatocellular miR-3129 was highly expressed in plasma EVs from HCC patients, which was the essential diagnostic biomarker for HCC. +circRNA target 33563550 hsa-mir-145 pancreatic ductal adenocarcinoma CircRNA_000684 negatively regulated miR-145 expression, while miR-145 negatively regulated KLF5. In-vivo, circRNA_000684 elevation or miR-145 repression promoted tumor growth. +circulation_biomarker_prognosis_ns 33563317 hsa-mir-9 Ovarian Neoplasms Low expression of miR-9 indicates poor prognosis of OC patients. +circRNA target 33563314 hsa-mir-145 Ovarian Neoplasms MiR-145 was a direct target of circVPS13C. Propofol suppressed the progression of ovarian cancer through up-regulating miR-145 via suppressing circVPS13C. +circulation_biomarker_diagnosis_up 33563011 hsa-mir-4292 Stroke After adjusting for potential confounders, we found plasma levels of 3 miRNAs to be associated with incident stroke (false discovery rate-adjusted P<0.05). These include miR-6124 (hazard ratio, 1.66 [95% CI, 1.31-2.09]), miR-5196-5p (hazard ratio, 1.90 [95% CI, 1.39-2.61]), and miR-4292 (hazard ratio, 2.65 [95% CI, 1.62-4.34]). +circulation_biomarker_diagnosis_up 33563011 hsa-mir-6124 Stroke After adjusting for potential confounders, we found plasma levels of 3 miRNAs to be associated with incident stroke (false discovery rate-adjusted P<0.05). These include miR-6124 (hazard ratio, 1.66 [95% CI, 1.31-2.09]), miR-5196-5p (hazard ratio, 1.90 [95% CI, 1.39-2.61]), and miR-4292 (hazard ratio, 2.65 [95% CI, 1.62-4.34]). +circulation_biomarker_diagnosis_up 33563011 hsa-mir-5196 Stroke After adjusting for potential confounders, we found plasma levels of 3 miRNAs to be associated with incident stroke (false discovery rate-adjusted P<0.05). These include miR-6124 (hazard ratio, 1.66 [95% CI, 1.31-2.09]), miR-5196-5p (hazard ratio, 1.90 [95% CI, 1.39-2.61]), and miR-4292 (hazard ratio, 2.65 [95% CI, 1.62-4.34]). +tissue_expression_down 33562968 hsa-let-7c Breast Neoplasms The miR-4324 and cluster of miR-99a/let7c/miR-125b dominated in the group of miRNAs with lower expression in cancer tissues compared to normal tissues. +tissue_expression_down 33562968 hsa-mir-4324 Breast Neoplasms The miR-4324 and cluster of miR-99a/let7c/miR-125b dominated in the group of miRNAs with lower expression in cancer tissues compared to normal tissues. +tissue_expression_up 33562968 hsa-mir-21 Breast Neoplasms The analyses of the lowest FDR p-value and the highest logFC value selected the oncomiR miR-182 as the most dominant with higher expression in cancer tissues than in normal tissues, followed by miR-21, miR342-3p/5p and miR-6826. +tissue_expression_up 33562968 hsa-mir-182 Breast Neoplasms The analyses of the lowest FDR p-value and the highest logFC value selected the oncomiR miR-182 as the most dominant with higher expression in cancer tissues than in normal tissues, followed by miR-21, miR342-3p/5p and miR-6826. +tissue_expression_up 33562968 hsa-mir-342 Breast Neoplasms The analyses of the lowest FDR p-value and the highest logFC value selected the oncomiR miR-182 as the most dominant with higher expression in cancer tissues than in normal tissues, followed by miR-21, miR342-3p/5p and miR-6826. +tissue_expression_down 33562968 hsa-mir-125b Breast Neoplasms The miR-4324 and cluster of miR-99a/let7c/miR-125b dominated in the group of miRNAs with lower expression in cancer tissues compared to normal tissues. +tissue_expression_up 33562968 hsa-mir-6826 Breast Neoplasms The analyses of the lowest FDR p-value and the highest logFC value selected the oncomiR miR-182 as the most dominant with higher expression in cancer tissues than in normal tissues, followed by miR-21, miR342-3p/5p and miR-6826. +tissue_expression_down 33562968 hsa-mir-99a Breast Neoplasms The miR-4324 and cluster of miR-99a/let7c/miR-125b dominated in the group of miRNAs with lower expression in cancer tissues compared to normal tissues. +other 33562573 hsa-mir-136 Thyroid Neoplasms We then selected three miRNAs (miR-136, miR-21, and miR-127) that were differentially expressed between the PTC follicular variant and other variants in The Cancer Genome Atlas data. +other 33562573 hsa-mir-127 Thyroid Neoplasms We then selected three miRNAs (miR-136, miR-21, and miR-127) that were differentially expressed between the PTC follicular variant and other variants in The Cancer Genome Atlas data. +other 33562573 hsa-mir-21 Thyroid Neoplasms We then selected three miRNAs (miR-136, miR-21, and miR-127) that were differentially expressed between the PTC follicular variant and other variants in The Cancer Genome Atlas data. +circulation_biomarker_diagnosis_down 33562569 hsa-let-7b Multiple Sclerosis Additionally, we found that the CSF let-7b-5p levels were significantly reduced in patients with the progressive MS compared to patients with relapsing-remitting MS and were negatively correlated with characteristic hallmark processes of the two phases of the disease. +other 33562297 hsa-mir-15a Neuroblastoma These analyses showed that miRNA-15a, 1, -19b, -218, and -338 were down-regulated in ER-HTLA cells. +circulation_biomarker_diagnosis_ns 33562261 hsa-mir-140 Osteoarthritis, Knee 5p) known to be related to OA progression were evaluated in the serum of 27 patients. +circulation_biomarker_diagnosis_ns 33562261 hsa-let-7e Osteoarthritis, Knee 5p) known to be related to OA progression were evaluated in the serum of 27 patients. +circulation_biomarker_diagnosis_ns 33562261 hsa-mir-454 Osteoarthritis, Knee 5p) known to be related to OA progression were evaluated in the serum of 27 patients. +circulation_biomarker_diagnosis_ns 33562261 hsa-mir-885 Osteoarthritis, Knee 5p) known to be related to OA progression were evaluated in the serum of 27 patients. +circRNA target 33561315 hsa-mir-296 Glioma Luciferase reports and RNA immunoprecipitation data indicated that miR-296-3p was a direct target of circHECTD1 and that the miR-296-3p expression negatively regulated SLC10A7. +other 33561291 hsa-mir-23b Heart Diseases In addition to being potential cardiac disease-specific markers, miR-23b/27b/24-1 were reported to be responsible for conferring cardiac pathophysiological processes. +other 33560588 hsa-mir-181b Carcinoma, Renal Cell In conclusion, we identified the oncogenic role of circCSNK1G3 in RCC progression and demonstrated the regulatory role of circCSNK1G3 induced miR-181b expression, which leads to TIMP3-mediated EMT process, thus resulting in tumour growth and metastasis in RCC. +target gene 33560516 hsa-mir-140 Aortic Dissection miR-140-5p repressed the proliferation, migration and invasion of vascular smooth muscle cells by targeting and inhibiting the expression of NCKAP1. +lncRNA target 33560148 hsa-mir-185 Parkinson Disease CONCLUSION: This study illustrates that miR-185 ameliorates dopaminergic neuron damage via targeting IGF1 and activating PI3K/AKT signalling pathway in PD, which renews the therapy for PD. +target gene 33560141 hsa-mir-635 Carcinoma, Non-Small-Cell Lung Circ_0000735 functions as a miR-635 sponge. FAM83F is targeted by miR-635. +circRNA target 33559936 hsa-mir-93 Cardiomegaly On the whole, the present study revealed that circ-Zfp644 aggravated CH through modulating the miR5p/Limk1 axis. +circulation_biomarker_diagnosis_up 33559872 hsa-mir-126 Intracranial Arterial Diseases OBJECTIVE: This study aimed to investigate the correlation between the circulating miR-126 regulation pathway and the cerebral collateral circulation (CCC), and to test whether miR-126 could serve as a potential biomarker for CCC formation in patients with intracranial arterial stenosis or occlusion. +genetics_knock down_promote 33559868 hsa-mir-101 Colonic Neoplasms ERO1alpha knockdown up-regulated miR-101 expression and promoted colon cancer cell apoptosis via regulating miR-101. +genetics_overexpression_suppress 33559830 hsa-mir-101a Epilepsy Overexpression of miR-101a-3p attenuated pilocarpine-induced epilepsy in Rats in vivo. +transcription factor target 33559506 hsa-mir-26b Reperfusion Injury, Cerebral Ischemia These results suggest that miR-26b-5p had protective effects on CIRI and it may be a potential treatment target. +lncRNA target 33559250 hsa-mir-107 Pain, Inflammatory Increased miR-107 contribute to inflammatory pain by targeting and downregulating GLT-1 expression, implying a promising strategy for inflammatory pain. +genetics_knock down_promote 33559088 hsa-mir-1225 Carcinoma, Hepatocellular CONCLUSION: Circ_0091579 knockdown repressed HCC progression and tumorigenesis by regulating miR +genetics_knock down_promote 33558703 hsa-mir-203 Carcinoma, Non-Small-Cell Lung We employed CCK-8 proliferation, colony formation, and Transwell migration and invasion assays to evaluate the effects of miR-203 on NSCLC cell behaviors using loss- and gain-function approaches. +other 33558459 hsa-mir-195 Cognition Disorders Elevated miR-195 may play a role in regulating BDNF protein expression thereby influencing cognitive impairments in schizophrenia, suggesting that development of cognition enhancing treatment for schizophrenia may consider a micro-RNA based strategy. +other 33558459 hsa-mir-195 Schizophrenia Elevated miR-195 may play a role in regulating BDNF protein expression thereby influencing cognitive impairments in schizophrenia, suggesting that development of cognition enhancing treatment for schizophrenia may consider a micro-RNA based strategy. +lncRNA target 33558335 hsa-mir-1 Lung Neoplasms SIGNIFICANCE: These findings demonstrate the oncogenic properties of miR-31 in specific subtypes of lung cancer and highlight it as a potential therapeutic target in these subtypes. +genetics_knock down_promote 33558275 hsa-mir-218 Arthritis, Rheumatoid Collectively, knockdown of miR +lncRNA target 33557774 hsa-mir-18a Cholangiocarcinoma MiR-18a-5p was increased in intrahepatic cholangiocarcinoma samples, and its expression was negatively correlated with that of MT1JP. CONCLUSIONS: MT1JP alleviated proliferation, migration and invasion, and induced apoptosis in cholangiocarcinoma cells by regulating miR-18a-5p/FBP1 axis. +genetics_knock down_promote 33557670 hsa-mir-6727 Uterine Cervical Neoplasms Knockdown of TBX1 reversed the inhibitory effect of the miR +other 33557426 hsa-mir-1 Metabolic Diseases The addition of smoking to miR-133b and miR-122 enhanced the prediction of CAVI. +other 33557426 hsa-mir-133 aortic atherosclerosis The addition of smoking to miR-133b and miR-122 enhanced the prediction of CAVI. +other 33557426 hsa-mir-1 aortic atherosclerosis The addition of smoking to miR-133b and miR-122 enhanced the prediction of CAVI. +other 33557426 hsa-mir-132 aortic atherosclerosis Previously, miR-1, miR-122, miR-126, miR-132, miR-133, and miR-370 were found to be related to coronary artery disease (CAD) progression. +other 33557426 hsa-mir-370 Metabolic Diseases Previously, miR-1, miR-122, miR-126, miR-132, miR-133, and miR-370 were found to be related to coronary artery disease (CAD) progression. +other 33557426 hsa-mir-132 Metabolic Diseases Previously, miR-1, miR-122, miR-126, miR-132, miR-133, and miR-370 were found to be related to coronary artery disease (CAD) progression. +other 33557426 hsa-mir-122 Metabolic Diseases The addition of smoking to miR-133b and miR-122 enhanced the prediction of CAVI. +other 33557426 hsa-mir-133b aortic atherosclerosis The addition of smoking to miR-133b and miR-122 enhanced the prediction of CAVI. +other 33557426 hsa-mir-126 Metabolic Diseases Previously, miR-1, miR-122, miR-126, miR-132, miR-133, and miR-370 were found to be related to coronary artery disease (CAD) progression. +other 33557426 hsa-mir-370 aortic atherosclerosis Previously, miR-1, miR-122, miR-126, miR-132, miR-133, and miR-370 were found to be related to coronary artery disease (CAD) progression. +other 33557426 hsa-mir-126 aortic atherosclerosis Previously, miR-1, miR-122, miR-126, miR-132, miR-133, and miR-370 were found to be related to coronary artery disease (CAD) progression. +other 33557426 hsa-mir-133b Metabolic Diseases The addition of smoking to miR-133b and miR-122 enhanced the prediction of CAVI. +other 33557426 hsa-mir-133 Metabolic Diseases The addition of smoking to miR-133b and miR-122 enhanced the prediction of CAVI. +other 33557426 hsa-mir-122 aortic atherosclerosis The addition of smoking to miR-133b and miR-122 enhanced the prediction of CAVI. +circulation_biomarker_diagnosis_up 33557217 hsa-mir-9 Brain Injuries, Traumatic In sTBI patients, plasma miR3p levels were 6.5- and 9.2-fold in comparison to the mTBI and control groups, respectively. +circulation_biomarker_diagnosis_ns 33557217 hsa-mir-136 Brain Injuries, Traumatic Thus, plasma miR +lncRNA target 33557205 hsa-mir-5004 Severe Acute Respiratory Syndrome 3p was the only human microRNA able to target the leader sequence of SARS and to a lesser extent, also SARS-CoV-2. +genetics_overexpression_promote 33557163 hsa-mir-224 Carcinoma, Renal Cell The overexpression of miR +genetics_knock down_suppress 33557112 hsa-mir-21 Buschke-Ollendorff syndrome Following the knockout of miR-21 from MDA-MB-231 cells, which have the highest miR-21 expression levels compared to MCF-7 and SK-BR-3 BCa cells, a decrease in epithelial-mesenchymal transition (EMT) via downregulation of mesenchymal markers was observed. +other 33556718 hsa-mir-19b Heart Diseases Mechanistically, the decreased expression of miR-19b might be responsible for the enhanced inflammation in the placenta. +other 33556718 hsa-mir-19b Obesity, Maternal Mechanistically, the decreased expression of miR-19b might be responsible for the enhanced inflammation in the placenta. +transcription factor target 33556577 hsa-mir-122 Coronary Artery Disease Mir-122 plays a role in cholesterol biosynthesis and deteriorates the cardiovascular system through the process of inflammation, apoptosis, oxidative stress and ECM deposition in a number of cardiovascular diseases. +circulation_biomarker_diagnosis_ns 33556577 hsa-mir-126 Coronary Artery Disease METHODS: Circulating miR-126 & 122 levels were measured in serum from 78 CAD patients and 60 non CDA patients by qRT-PCR analysis. +transcription factor target 33556563 hsa-mir-34 Hypoxia-Ischemia, Brain Our results suggest that EA treatment alleviates ischaemic brain injury by inhibiting autophagy through the miR-34/Wnt pathway. +other 33556337 hsa-mir-148a hypotrichosis 8 13 miRNAs were predicted to regulate the expressions of ADH1A, ADH4, and ALDH2, respectively, with hsa-miR-148a-3p (miR-148a) showing the most significant down-regulation in AH patients. In sum, our results suggest that the expressions of key alcohol-metabolizing enzymes are repressed in AH patients, and the non-canonical positive regulation of miR-148a on ADH4 reveals a new regulationary mechanism for ADH genes. +genetics_knock down_promote 33556191 hsa-mir-152 Prostatic Neoplasms Knockdown of circANKS1B markedly suppressed cell migration and invasion and TGF-alpha expression in PC cells, whereas the effects of circANKS1B silencing were reversed by miR +lncRNA target 33555529 hsa-mir-424 Breast Neoplasms 5p might increase BC chemosensitivity through the regulation of apoptosis-related factors including P53, Caspase-3, Bcl-2, and Bax as well as the proliferation-related gene c-Myc. +genetics_knock down_promote 33555514 hsa-mir-429 Stomach Neoplasms Furthermore, miR-429 directly targeted PD-L1, and overexpression of miR-429 suppressed GC tumorigenesis via PD-L1. +other 33555315 hsa-mir-142 Tauopathies 3p-regulated cortical myelination and oligodendrocyte-mediated synaptic signaling in neurodegeneration. +exosome 33555177 hsa-mir-10b Pancreatic Carcinoma Using exosomal miRNA-10b as a proof of concept, pancreatic ductal adenocarcinoma (PDAC) patients can be recognized from normal controls (NCs) with an accuracy of 99.6%. +exosome 33555177 hsa-mir-10b Carcinoma, Pancreatic Ductal Using exosomal miRNA-10b as a proof of concept, pancreatic ductal adenocarcinoma (PDAC) patients can be recognized from normal controls (NCs) with an accuracy of 99.6%. +other 33554246 hsa-mir-196a-2 Carcinoma, Non-Small-Cell Lung However, the association of miR-196a-2 rs11614913 with a decreased risk of NSCLC was identified in the female subgroup (adjusted P=0.005, power = 0.809 for TC vs. However, this case-control study demonstrates that miR-196a-2 rs11614913 may be a protective factor for the development of NSCLC among female patients. +epigenetics 33554000 hsa-mir-449 Infertility CONCLUSION: In this study, low expression and high methylation of hsa-miR +epigenetics 33554000 hsa-mir-449b Infertility CONCLUSION: In this study, low expression and high methylation of hsa-miR +circulation_biomarker_diagnosis_ns 33553977 hsa-mir-885 Fibrosis Patients with cirrhosis had lower serum levels of miR-429, miR +circulation_biomarker_diagnosis_ns 33553977 hsa-mir-181b Fibrosis Patients with cirrhosis had lower serum levels of miR-429, miR +other 33553977 hsa-mir-452 Fibrosis 5p were inversely correlated with baseline systemic vascular resistance (rho = -0.46, P = 0.007; and rho = -0.41, P = 0.01, respectively) and with diminished systolic contractility (rho = -0.55, P = 0.02; and rho = -0.55, P = 0.02, respectively) in patients with refractory ascites after NSBBs. +circulation_biomarker_diagnosis_ns 33553977 hsa-mir-29a Fibrosis Patients with cirrhosis had lower serum levels of miR-429, miR +circulation_biomarker_diagnosis_ns 33553977 hsa-mir-192 Fibrosis Patients with cirrhosis had lower serum levels of miR-429, miR +circulation_biomarker_diagnosis_ns 33553977 hsa-mir-429 Fibrosis Patients with cirrhosis had lower serum levels of miR-429, miR +circulation_biomarker_diagnosis_ns 33553977 hsa-mir-34a Fibrosis Serum samples from patients with decompensated cirrhosis (n = 36) and healthy controls (n = 36) were tested for a novel signature of five miRNAs (miR +circulation_biomarker_diagnosis_ns 33553977 hsa-mir-122 Fibrosis Patients with cirrhosis had lower serum levels of miR-429, miR +lncRNA target 33553684 hsa-mir-1206 Coronary Artery Disease The results found that the relative expression of SNHG14 was significantly upregulated in I/R, but suppressed in PTX treated groups with enhancement of the relative expression level of miR-1206. +lncRNA target 33553515 hsa-mir-145 Cystic Fibrosis In particular, some microRNAs involved in CF and/or CFTR regulation are co-inhibited by miR +lncRNA target 33553515 hsa-mir-101 Cystic Fibrosis "These data here presented are relative to two companion articles ""Treatment of human airway epithelial Calu-3 cells with a Peptide-Nucleic Acid (PNA) targeting the microRNA miR" +genetics_overexpression_promote 33553298 hsa-mir-26a Endometrial Neoplasms Furthermore, the overexpression of miR-26a-5p inhibited the progression of EC, including cell migration, cell proliferation, and cell apoptosis in vivo and in vitro. +lncRNA target 33553184 hsa-mir-7 Keloid 5p to release Epac1, which contributed to pathological hyperplasia of keloids through activating the PI3K/Akt signaling pathway. +lncRNA target 33553139 hsa-mir-29b Osteoporosis Herein, we identified bone marrow MSC (BMSC)-derived EVs harboring microRNA (miR)-29b-3p to regulate osteogenic differentiation through effects on the suppressor of cytokine signaling 1 (SOCS1)/nuclear factor (NF)-kappaB pathway via targeting of lysine demethylase 5A (KDM5A) in osteoporosis. +other 33552974 hsa-mir-205 Breast Neoplasms, Basal Cell circ_NOTCH3, being an protooncogene and a powerful biomarker, can function as a sponge, compete with miR5p, modulate KLF12 expression, and promote the development and progression of BLBC. +lncRNA target 33552968 hsa-mir-141 Cholangiocarcinoma In summary, our results highlighted the important role of the lncRNA-PAICC-miR3p/27a-3p-Yap1 axis in ICC, which offers a novel perspective on the molecular pathogenesis and may serve as a potential target for antimetastatic molecular therapies of ICC. +lncRNA target 33552968 hsa-mir-27a Cholangiocarcinoma In summary, our results highlighted the important role of the lncRNA-PAICC-miR3p/27a-3p-Yap1 axis in ICC, which offers a novel perspective on the molecular pathogenesis and may serve as a potential target for antimetastatic molecular therapies of ICC. +lncRNA target 33552958 hsa-mir-145 Digestive System Neoplasms In conclusion, the present study found that SERPINE1/has-mir-145/SNHG1 axis acted as promising targets and the hub genes reasoned the similarity between ESCA and READ, which revealed the homogeneous tumorigenicity of digestive tract cancers at the transcriptome level and led to further comprehension and therapeutics for digestive tract cancers. +genetics_knock down_promote 33552887 hsa-mir-219a Osteosarcoma CONCLUSION: Our finding demonstrated that circ_0007534 knockdown suppressed the growth of OS cells via regulating miR-219a-5p/SOX5 axis, providing a potential target for OS treatment and diagnosis. +genetics_knock down_promote 33552886 hsa-mir-217 Osteosarcoma CONCLUSION: Knockdown of circANKIB1 suppressed OS progression by upregulating miR-217 and downregulating PAX3, which might provide a novel insight into the pathogenesis of OS. +genetics_overexpression_promote 33552829 hsa-mir-192 Cholangiocarcinoma Overexpression of miR +other 33552286 hsa-mir-18a Carcinoma, Hepatocellular ROC analysis demonstrated that miR-18a, miR-27a and miR-20b could discriminate metastatic HCC from non-metastatic HCC. +other 33552286 hsa-mir-27a Carcinoma, Hepatocellular ROC analysis demonstrated that miR-18a, miR-27a and miR-20b could discriminate metastatic HCC from non-metastatic HCC. +other 33552286 hsa-mir-20b Carcinoma, Hepatocellular ROC analysis demonstrated that miR-18a, miR-27a and miR-20b could discriminate metastatic HCC from non-metastatic HCC. +genetics_overexpression_promote 33552279 hsa-mir-640 Glioblastoma Furthermore, overexpression of SLIT1 attenuated the promotive effect of miR-640 on glioblastoma cells. +lncRNA target 33552275 hsa-mir-22 Glioma Functionally, MIR22HG regulated the proliferation, invasion and migration of the glioma cell line by targeting miR-9. +lncRNA target 33552275 hsa-mir-9 Glioma Functionally, MIR22HG regulated the proliferation, invasion and migration of the glioma cell line by targeting miR-9. +genetics_knock down_promote 33552274 hsa-mir-665 Glioma Besides, overexpression of miR-665 suppressed the proliferation, migration and invasion of glioma cells, while knockdown of miR-665 promoted these cellular behaviors. +other 33552270 hsa-mir-128 Osteosarcoma miR-128-3p serves as an oncogenic microRNA in osteosarcoma cells by downregulating ZC3H12D. +target gene 33552258 hsa-mir-7 Pancreatic Neoplasms MicroRNA-7 modulates cellular senescence to relieve gemcitabine resistance by targeting PARP1/NF-κB signaling in pancreatic cancer cells. +target gene 33552256 hsa-mir-141 Liver Neoplasms MicroRNA-200a and microRNA-141 have a synergetic effect on the suppression of epithelial-mesenchymal transition in liver cancer by targeting STAT4. +target gene 33552256 hsa-mir-200a Liver Neoplasms MicroRNA-200a and microRNA-141 have a synergetic effect on the suppression of epithelial-mesenchymal transition in liver cancer by targeting STAT4. +genetics_knock down_promote 33552251 hsa-mir-338 Ovarian Neoplasms 3p depletion or MCL1 overexpression could reverse the effects of SNHG20 knockdown on OC cells. +target gene 33552243 hsa-mir-139 Ovarian Neoplasms lncRNA SNHG3 acts as oncogene in ovarian cancer through miR-139-5p and Notch1. +other 33552001 hsa-mir-21 Tuberculosis Here we showed that intestinal dysbacteriosis increases the susceptibility to TB and remotely increased the expression of miR-21 in lung. Systemic antagonism of miR-21 enhanced IFN-gamma production and further conferred immune protection against TB. +lncRNA target 33551645 hsa-mir-26a Squamous Cell Carcinoma of Head and Neck CONCLUSION: This is the first report of LncRNA GAS5 acting as a tumor suppressor in LSCC by regulating the miR-26a-5p/ULK2 axis, and it could be a new target for gene therapy in LSCC. +genetics_knock down_suppress 33551225 hsa-mir-1275 Cardiomyopathies OBJECTIVE: This research was designed to investigate the function of miR-1275 in hypoxia/reoxygenation (H/R)-induced myocardial injury and its in-depth mechanism. Furthermore, our data also suggested that inhibition of miR-1275 can significantly alleviate H/R-induced myocardial injury, which can also markedly decrease the concentration of pro-inflammatory factors TNF-alpha, IL-1 beta and increase the concentration of anti-inflammatory factors IL-10 in H/R-treated AC16 cells, while knockdown of HK2 canceled the effect caused by miR-1275 deletion. +transcription factor target 33551225 hsa-mir-1275 Heart Failure RESULTS: We found that miR-1275 was highly expressed in patients with heart failure and H/R treated AC16 cells than that in control group, and inhibition of miR-1275 can alleviate induced-decrease of cell viability. +target gene 33550958 hsa-mir-34c Breast Neoplasms In conclusion, corylin suppresses metastasis of breast cancer cells via increasing miR-34c expression, which was dependent on p53. +lncRNA target 33550957 hsa-mir-493 Carcinoma, Non-Small-Cell Lung 5p, while DDX5 was the target of miR +genetics_overexpression_promote 33550941 hsa-mir-1296 Glioma ABL2 was overexpressed in glioma tissues and inversely correlated with that of miR-1296. +genetics_overexpression_promote 33550933 hsa-mir-936 Carcinoma, Hepatocellular Functional study revealed that overexpression of miR-936 inhibited the proliferation, migration (decreased to 0.26 fold) and induced cell cycle arrested in G1 phase (from 35.3% to 44.7%) of HCC cells. +transcription factor target 33550923 hsa-mir-144 Prostatic Neoplasms miR-144 also suppressed epithelial-mesenchymal transition level of PCa cells. +other 33550900 hsa-mir-138 Pre-Eclampsia miR-138 expression was upregulated in preeclampsia placenta and LPS-stimulated HTR-8/SVneo and JEG-3 cell lines. The miR-138/RELA axis might be involved in preeclampsia pathogenesis, which requires further in vivo and clinical researches. +genetics_knock down_promote 33550894 hsa-mir-22 Liver Cirrhosis Knockdown of Neat1 inhibited Cyth3 expression via the competing endogenous RNA (ceRNA) mechanism of sponging miR-148a-3p and miR +genetics_knock down_promote 33550894 hsa-mir-148a Liver Cirrhosis Knockdown of Neat1 inhibited Cyth3 expression via the competing endogenous RNA (ceRNA) mechanism of sponging miR-148a-3p and miR +lncRNA target 33550882 hsa-mir-378a Obesity Taken together, our findings demonstrate that betaine can improve obesity and associated MS via the gut microbiota-derived miR-378a/YY1 regulatory axis, and reveal a novel mechanism by which gut microbiota improve host health. +other 33550817 hsa-mir-21 Cardiomyopathies CONCLUSIONS: Our data indicate a critical role of cMPs in pressure overload-induced cardiac fibrosis and dysfunction and reveal macrophage miR-21 as a key molecule for the profibrotic role of cMPs. +other 33550766 hsa-mir-20a Prostatic Neoplasms We considered that MIR320A has been evaluated as a valuable biomarker that can be used in the early diagnosis of PC. +lncRNA target 33550476 hsa-mir-4497 Squamous Cell Carcinoma of Head and Neck CONCLUSION: Taken together, FEZF1-AS1, heightened in LSCC tissues and cells, promotes cell migration and invasion of LSCC cells via targeting miR-4497 that inhibits GBX2. +other 33550299 hsa-mir-663a Breast Neoplasms Low Expression of miR-663a Indicates Poor Prognosis and Promotes Cell Proliferation, Migration, and Invasion in Breast Cancer. +lncRNA target 33550286 hsa-let-7a Obesity, Morbid For the first time, we proved that HMGA2, a target gene of let-7a-5p, is upregulated in the SAT of morbidly obese Chinese women. +circulation_biomarker_diagnosis_up 33550282 hsa-mir-378a Sleep Apnea Syndromes 5p) that were functionally associated with the cardiovascular system that predicted a favorable blood pressure (BP) response to continuous positive airway pressure (CPAP) treatment in patients with resistant hypertension (RH) and obstructive sleep apnea (OSA) (HIPARCO score). +circulation_biomarker_diagnosis_up 33550282 hsa-mir-100 Sleep Apnea Syndromes 5p) that were functionally associated with the cardiovascular system that predicted a favorable blood pressure (BP) response to continuous positive airway pressure (CPAP) treatment in patients with resistant hypertension (RH) and obstructive sleep apnea (OSA) (HIPARCO score). +circulation_biomarker_diagnosis_up 33550282 hsa-mir-486 Sleep Apnea Syndromes 5p) that were functionally associated with the cardiovascular system that predicted a favorable blood pressure (BP) response to continuous positive airway pressure (CPAP) treatment in patients with resistant hypertension (RH) and obstructive sleep apnea (OSA) (HIPARCO score). +circulation_biomarker_diagnosis_down 33550188 hsa-mir-124 Lupus Erythematosus, Systemic We further isolated CD4 T cells from the peripheral blood samples of SLE patients and healthy individuals, and found that miR-124 was poorly expressed in peripheral blood-derived CD4 T cells of SLE patients. +other 33550149 hsa-mir-187 Osteoporosis However, the function and mechanism of miR-187 in osteoporotic fractures are still unknown. CONCLUSIONS: The miR-187 might have a significant therapeutic effect in osteoporotic fractures. +genetics_GWAS 33550076 hsa-mir-76 Poikiloderma with Neutropenia Using ROS production and locomotion behavior as endpoints, mutation of glb-10 inhibited resistance of mir-76 mutant to NPS toxicity, and neuronal overexpression of mir-76 inhibited the resistance to NPS toxicity in nematodes overexpressing neuronal glb-10 containing 3' untranslated region (3'UTR). +circulation_biomarker_diagnosis_ns 33550035 hsa-mir-23a Colorectal Neoplasms Furthermore, we identified four exosomal miRNAs (miR-126, miR-1290, miR-23a, and miR-940) in the serum of CRC patients as novel potential biomarkers for the early diagnosis of CRC because they showed high diagnostic values to differentiate CRC patients at TNM stage I from healthy controls (HCs). In conclusion, we identified serum exosomal miR-126, miR-1290, miR-23a, and miR-940 as novel potential biomarkers for the early diagnosis of CRC. +circulation_biomarker_diagnosis_ns 33550035 hsa-mir-126 Colorectal Neoplasms Furthermore, we identified four exosomal miRNAs (miR-126, miR-1290, miR-23a, and miR-940) in the serum of CRC patients as novel potential biomarkers for the early diagnosis of CRC because they showed high diagnostic values to differentiate CRC patients at TNM stage I from healthy controls (HCs). In conclusion, we identified serum exosomal miR-126, miR-1290, miR-23a, and miR-940 as novel potential biomarkers for the early diagnosis of CRC. +circulation_biomarker_diagnosis_ns 33550035 hsa-mir-940 Colorectal Neoplasms Furthermore, we identified four exosomal miRNAs (miR-126, miR-1290, miR-23a, and miR-940) in the serum of CRC patients as novel potential biomarkers for the early diagnosis of CRC because they showed high diagnostic values to differentiate CRC patients at TNM stage I from healthy controls (HCs). In conclusion, we identified serum exosomal miR-126, miR-1290, miR-23a, and miR-940 as novel potential biomarkers for the early diagnosis of CRC. +circulation_biomarker_diagnosis_ns 33550035 hsa-mir-1290 Colorectal Neoplasms Furthermore, we identified four exosomal miRNAs (miR-126, miR-1290, miR-23a, and miR-940) in the serum of CRC patients as novel potential biomarkers for the early diagnosis of CRC because they showed high diagnostic values to differentiate CRC patients at TNM stage I from healthy controls (HCs). In conclusion, we identified serum exosomal miR-126, miR-1290, miR-23a, and miR-940 as novel potential biomarkers for the early diagnosis of CRC. +genetics_overexpression_suppress 33549904 hsa-mir-126 Pre-Eclampsia Moreover, transient overexpression of miR +genetics_knock down_promote 33549125 hsa-mir-143 Arthritis, Rheumatoid 3p upregulation or TNFAIP3 knockdown. +transcription factor target 33549119 hsa-mir-18a Heart Failure CONCLUSION: Collectively, our findings indicate that HDAC3 silencing confers protection against HF by inhibiting miR-18a-targeted ADRB3. +lncRNA target 33549106 hsa-mir-455 Pulmonary Fibrosis CONCLUSION: Taken together, our study demonstrated that SNHG16 promoted pulmonary fibrosis by targeting miR3p to regulate the Notch2 pathway. +genetics_knock down_promote 33549034 hsa-mir-127 Multiple Myeloma Additionally, knockdown of miR +other 33548980 hsa-mir-152 Diabetes Mellitus, Type 2 In conclusion, such findings may indicate a pathologic role of micro-RNA 152-3p in Type 2 diabetes mellitus and in the progression of diabetic nephropathy. +other 33548980 hsa-mir-152 Diabetic Nephropathies In conclusion, such findings may indicate a pathologic role of micro-RNA 152-3p in Type 2 diabetes mellitus and in the progression of diabetic nephropathy. +circulation_biomarker_diagnosis_ns 33548978 hsa-mir-483 Alzheimer Disease Plasma levels of miRNA +transcription factor target 33548704 hsa-mir-15b Inflammation Taken together, miR-15b-5p targeted ATF2 to mediate METs release, which triggered trachea inflammatory injury via MAPK and insulin signals after H(2)S exposure. +other 33548653 hsa-mir-21 Pancreatic Carcinoma We report a limit of detection of 2 pM in less than 1 min for miR-21 alone, and then demonstrate that miR-21 levels, measured in fine needle biopsy samples, from patients with pancreatic cancer correlate with the reference technique of reverse-transcription polymerase chain reaction (RT-PCR). +lncRNA target 33548626 hsa-mir-126 Pre-Eclampsia These results indicate that miR-126 suppresses JEG-3 cell invasion by targeting LIN28A, and suggest that miR +other 33548242 hsa-mir-21 Stenosis, Pulmonary Artery Herein, we investigated the role of miR-21 in RV dysfunction using a sheep model of PAH secondary to pulmonary arterial constriction (PAC). +lncRNA target 33548242 hsa-mir-21 Ventricular Dysfunction, Right Herein, we investigated the role of miR-21 in RV dysfunction using a sheep model of PAH secondary to pulmonary arterial constriction (PAC). Collectively, our in vitro and in vivo data demonstrate that miR-21 is a critical contributor in the development of RV dysfunction and could represent a novel therapeutic target for PAH associated RV dysfunction. +lncRNA target 33548242 hsa-mir-21 Hypertension, Pulmonary Collectively, our in vitro and in vivo data demonstrate that miR-21 is a critical contributor in the development of RV dysfunction and could represent a novel therapeutic target for PAH associated RV dysfunction. +other 33548006 hsa-mir-496 Arthritis, Rheumatoid Expression of miR-496 and MMP10 was determined based on the clinical samples with RA retrieved from the Gene Expression Omnibus (GEO) datasets. miR-496 expression was decreased in RA tissues and MH7A cells after IL-1beta treatment. +lncRNA target 33548000 hsa-mir-181c Spinal Cord Injuries In conclusion, we verified that BMSCs-exo could protect against SCI through its content microRNA-181c which suppressed the inflammation in microglia and spinal cord. +other 33547612 hsa-mir-3178 Stomach Neoplasms CONCLUSION: miR-3178 may be involved in the progression of gastric cancer, which provides new insights into the treatment of gastric cancer. +exosome 33546766 hsa-mir-22 Brain Ischemia CONCLUSION: Results support a conclusion that ASC-EV-derived miR3p could alleviate brain ischemic injury by inhibiting KDM6B-mediated effects on the BMP2/BMF axis. +exosome 33546686 hsa-mir-501 Lung Neoplasms 3p inhibition reversed the effect of M2 exosomes on LC cells. +other 33546604 hsa-mir-361 Acute Coronary Syndrome 5p expression in ACS might be a candidate biomarker for ACS diagnosis and the the prediction of MACE onset. +other 33546438 hsa-mir-106a Autism Spectrum Disorde The Si-NR chips were then used for the highly sensitive nanoelectronics detection of DNA oligonucleotides (oDNAs), which represent synthetic analogs of 106a-5p microRNA (miR-106a-5p), associated with the development of autism spectrum disorders in children. +lncRNA target 33545926 hsa-mir-365 Ovarian Neoplasms OC cells were transfected with sh-NEAT1, pcDNA3.1-NEAT1, miR-365 mimic, miR-365 inhibitor or pcDNA3.1-NEAT1 sh-NEAT1 before cell proliferation rate and cell clone formation rate were measured. CONCLUSION: LncRNA NEAT1 up-regulates FGF9 by sponging miR-365, thus promoting OC cell proliferation and angiogenesis of HUVECs. +genetics_overexpression_promote 33545873 hsa-mir-532 Stomach Neoplasms 3p@PLGA-PEG-VB12 NPs) to fight against transcobalamin II (CD320)-overexpressed GC cells' progression. +genetics_overexpression_suppress 33545365 hsa-mir-181b Coronary Stenosis In contrast, miR-181b-5p was downregulated in the CSF-induced HUVECs, and miR-181b-5p overexpression improved endothelial function. +circRNA target 33545359 hsa-mir-130a Urinary Bladder Neoplasms Our findings highlighted that the circEHBP1/miR-130a-3p/TGFbetaR1/VEGF-D axis contributes to lymphangiogenesis and lymphatic metastasis of bladder cancer independent of VEGF-C, which might lead to the development of circEHBP1 as a potential biomarker and promising therapeutic target for lymphatic metastasis in bladder cancer. +other 33545201 hsa-mir-15b Fibrosis However, the roles of miR-15b/16 in liver fibrosis remain unclear. +transcription factor target 33545160 hsa-mir-138 Breast Neoplasms 5p restrains T-cell exhaustion via suppressing PD-L-1 expression in BC cells leading to disrupt PD-L-1/PD-1 interaction and modulate effector cytokines in T-cells. +other 33544468 hsa-mir-216a Cholangiocarcinoma This study revealed that PCAT1 acted as an oncogene in CCA, and the YY1/PCAT1/miR-216a-3p/BCL3 axis exhibited critical functions in CCA progression. +circulation_biomarker_diagnosis_down 33544209 hsa-mir-188 Breast Neoplasms 5p inhibitor, siFBXW7, and c-Myc plasmids were transfected into cancer cells to evaluate whether miR +other 33543866 hsa-mir-223 Leukemia, Prolymphocytic, T-Cell Furthermore, increased expression of miR3p as well as reduced expression of miR-21 and the miR-29 cluster were associated with more activated Tcell phenotypes and more aggressive disease presentations. +other 33543866 hsa-mir-21 Leukemia, Prolymphocytic, T-Cell Furthermore, increased expression of miR3p as well as reduced expression of miR-21 and the miR-29 cluster were associated with more activated Tcell phenotypes and more aggressive disease presentations. +lncRNA target 33543830 hsa-mir-1205 Glioma CONCLUSION: Our current findings identified that circ-UBAP2 silencing impeded glioma malignant progression partially by downregulating GPRC5A through targeting miR-1205 and miR-382. +lncRNA target 33543830 hsa-mir-382 Glioma CONCLUSION: Our current findings identified that circ-UBAP2 silencing impeded glioma malignant progression partially by downregulating GPRC5A through targeting miR-1205 and miR-382. +genetics_knock down_promote 33543608 hsa-mir-1274a Osteosarcoma The overexpression of miR-1274a could inhibit OS cell proliferation, migration and invasion. +other 33543022 hsa-mir-200b Breast Neoplasms miR-200b restrains EMT and aggressiveness and regulates matrix composition depending on ER status and signaling in mammary cancer. +other 33542956 hsa-mir-98 Atherosclerosis Mechanistically, XIST could regulate PAPPA expression in ox-LDL-induced HUVECs by sponging miR5p, providing understanding for atherosclerosis. +other 33542918 hsa-mir-146a Periodontal Diseases CONCLUSION: The main type of periodontal disease on which most studies are focused is chronic periodontitis, with the main miRNAs being hsa-miR-146a, hsa-miR-146b, hsa-miR-155, and hsa-miR-200. +other 33542918 hsa-mir-155 Periodontal Diseases CONCLUSION: The main type of periodontal disease on which most studies are focused is chronic periodontitis, with the main miRNAs being hsa-miR-146a, hsa-miR-146b, hsa-miR-155, and hsa-miR-200. +other 33542918 hsa-mir-200 Periodontal Diseases CONCLUSION: The main type of periodontal disease on which most studies are focused is chronic periodontitis, with the main miRNAs being hsa-miR-146a, hsa-miR-146b, hsa-miR-155, and hsa-miR-200. +other 33542901 hsa-mir-504 Clear-cell metastatic renal cell carcinoma NKX2-1 was found in metastatic ccRCC after the combination of data from expression, survival analysis, and experiment validation. +other 33542901 hsa-mir-28 Clear-cell metastatic renal cell carcinoma NKX2-1 was found in metastatic ccRCC after the combination of data from expression, survival analysis, and experiment validation. +other 33542901 hsa-mir-502 Clear-cell metastatic renal cell carcinoma NKX2-1 was found in metastatic ccRCC after the combination of data from expression, survival analysis, and experiment validation. +other 33542783 hsa-mir-210 Periodontitis In conclusion, the AA could enhance a protective effect in in vitro periodontitis model, downregulating the inflammatory pathway and ROS generation and modulating the miR-210 level. +other 33542659 hsa-mir-1197 Carcinoma, Non-Small-Cell Lung CONCLUSION: Collectively, our results demonstrated that circ_0000429 exhibited a carcinogenic role by sponging miR-1197 and regulating CMADD expression in NSCLC. +other 33542656 hsa-mir-2467 Colorectal Neoplasms LINC01224 Promotes Colorectal Cancer Progression by Sponging miR-2467. +genetics_knock down_suppress 33542625 hsa-mir-130a Carcinoma, Non-Small-Cell Lung Moreover, exosomal miRNA-130a was transferred from CAFs to recipient NSCLC cells and knockdown of miRNA-130a reversed the effect of CAFs-derived exosomes during chemoresistance of NSCLC cells. +circulation_biomarker_diagnosis_ns 33542428 hsa-let-7i Persistent Neck-Pain Disability Peritraumatic blood-based microRNA expression levels predict PNPD following MVC and let-7i-5p might contribute to the underlying effects of neck MFI on persistent disability. +lncRNA target 33542221 hsa-mir-103a-2 Squamous Cell Carcinoma of Head and Neck We predicted through an online database and confirmed by dual-luciferase reporter assays that LTSCCAT is a competitive endogenous RNA for the regulation of miR-103a +genetics_knock down_promote 33542193 hsa-mir-651 Glioma 3p overexpression suppressed glioma cells proliferation, migration, and invasion and vasculogenic mimicry (VM) formation. +genetics_knock down_promote 33542185 hsa-mir-149 Ovarian Neoplasms This study highlights that knockdown of XIST elevates miR +genetics_knock down_promote 33542183 hsa-mir-335 Fractures, Bone The loss-of functions of miR-335 in B-EV and gain-of-functions of VapB were performed in animal and cell experiments to evaluate their roles in bone fracture. +lncRNA target 33541391 hsa-mir-589 Carcinoma, Hepatocellular CONCLUSIONS: CCDC183-AS1 functions as an oncogene to promote HCC progression through the CCDC183-AS1/miR +lncRNA target 33541373 hsa-mir-200 Breast Neoplasms RESULTS: Re-expression of the miR-200s in murine and human claudin-low mammary tumor cells partially restored an epithelial cell morphology and significantly inhibited proliferation and cell invasion in vitro. +lncRNA target 33541259 hsa-mir-125b Skin Neoplasms CONCLUSIONS: The results of luciferase reporter assay showed that MSI1 is a direct target for miR-125b in epithelial breast cancer cells. +transcription factor target 33541173 hsa-mir-6734 Alzheimer Disease 3p and its target mRNA CYTH4 might be used as novel biomarkers for MCI and AD. +other 33540826 hsa-mir-106a Neuralgia Treatment with PGA resulted in the following effects: (i) it prevented the NF-kB activation in LPS stimulated RAW264.7 cells; (ii) it decreased LPS-induced keratitis and corneal pro-inflammatory cytokines, whilst increasing anti-inflammatory cytokines; (iii) it normalized LPS-induced miR-20a-5p and miR-106a-5p upregulation and increased miR-27a-3p levels in the inflamed corneas; (iv) it decreased allodynia in peripheral neuropathy induced by oxaliplatin or formalin, but not following spared nerve injury of the sciatic nerve (SNI); (v) it prevented the formalin- or oxaliplatin-induced myelino-axonal degeneration of sciatic nerve. +other 33540826 hsa-mir-27a Neuralgia Treatment with PGA resulted in the following effects: (i) it prevented the NF-kB activation in LPS stimulated RAW264.7 cells; (ii) it decreased LPS-induced keratitis and corneal pro-inflammatory cytokines, whilst increasing anti-inflammatory cytokines; (iii) it normalized LPS-induced miR-20a-5p and miR-106a-5p upregulation and increased miR-27a-3p levels in the inflamed corneas; (iv) it decreased allodynia in peripheral neuropathy induced by oxaliplatin or formalin, but not following spared nerve injury of the sciatic nerve (SNI); (v) it prevented the formalin- or oxaliplatin-induced myelino-axonal degeneration of sciatic nerve. +other 33540650 hsa-mir-199a Influenza, Human 3p, 199a-3p, and miR-199a-5p compared to influenza A patients. +other 33540650 hsa-mir-375 Influenza, Human 3p, 199a-3p, and miR-199a-5p compared to influenza A patients. +other 33540574 hsa-mir-206 Adenocarcinoma of Lung In summary, the current study constructing a ceRNA-based WT1-AS/miR-206/NAMPT axis might be a novel important prognostic factor associated with the diagnosis and prognosis of LUAD. +circulation_biomarker_diagnosis_ns 33540559 hsa-mir-155 Obesity miR-155 expression was reduced and CEBPB mRNA levels were increased in MetS patients (p < 0.05), and these effects were correlated with the number of MetS diagnostic criteria (p < 0.05). Downregulation of circulating miR-155 is associated with insulin resistance, poor glycemic control, and increased MetS-related cardiometabolic risk, and these effects are potentially mediated by interaction with CEBPB. +circulation_biomarker_diagnosis_ns 33540559 hsa-mir-155 Metabolic Syndrome miR-155 expression was reduced and CEBPB mRNA levels were increased in MetS patients (p < 0.05), and these effects were correlated with the number of MetS diagnostic criteria (p < 0.05). Downregulation of circulating miR-155 is associated with insulin resistance, poor glycemic control, and increased MetS-related cardiometabolic risk, and these effects are potentially mediated by interaction with CEBPB. +genetics_knock down_promote 33539913 hsa-mir-124 Osteoarthritis Gain- or loss-of functional assays of SNHG14 and miR +other 33539779 hsa-mir-155 Esophageal Squamous Cell Carcinoma Together, these findings demonstrate that miR155 promotes susceptibility to CL caused by L. +circulation_biomarker_diagnosis_ns 33539284 hsa-mir-19b Shock, Hemorrhagic RESULTS: Pulmonary microRNA-19b was increased after haemorrhagic shock and lactated Ringers, but reduced to sham levels by plasma and fibrinogen. +other 33538533 hsa-mir-22 Myocardial Infarction Previous studies reported the regulation effects of microRNAs (miRNAs) in myocardial infarction, whereas function and molecular mechanisms of miR5p were still unclear. +other 33538509 hsa-mir-23a Sepsis RESULTS: In the rat model, miR-23a was poorly expressed in myocardial (sham vs. sepsis 1.00 /- 0.06 vs. 0.27 /- 0.03, P < 0.01) and kidney tissues (sham vs. sepsis 0.27 /- 0.03 vs. 1.00 /- 0.06, P < 0.01). +other 33538509 hsa-mir-23a Wound Infection In this study, we examined the role of miR-23a in septic injury. +other 33538177 hsa-mir-223 Cardiomyopathies Materials and methods: Using bioinformatics, both tissue-specific expression profiles and epigenomic profiles of some genes critical for cardiac fibrosis were examined, namely, NLRP3, MMP2, MMP9, CCN2/CTGF, AGT (encodes angiotensin II precursors) and hsa-mir-223 (post-transcriptionally regulates NLRP3). +other 33538126 hsa-mir-128-2 Burkitt Lymphoma DISCUSSION AND CONCLUSION: Our pilot study highlights two miRNAs (miR2-5p and miR-378C) as possible candidate biomarkers of relapsed B-ALL. +other 33538126 hsa-mir-378c Burkitt Lymphoma DISCUSSION AND CONCLUSION: Our pilot study highlights two miRNAs (miR2-5p and miR-378C) as possible candidate biomarkers of relapsed B-ALL. +lncRNA target 33538115 hsa-mir-96 Adenocarcinoma of Lung Mechanically, we identified that AIMP3 was a direct target of miR +transcription factor target 33538099 hsa-mir-210 Esophageal Squamous Cell Carcinoma In conclusion, data show that miR-210 serves as an anti-ESCC miR via down-regulation of FBXO31 and regulation of EMT and Wnt signaling, suggesting that the miR-210/FBXO31 axis may function as promising therapeutic targets and effective prognostic markers for ESCC patients. +other 33538066 hsa-mir-33a Pancreatic Neoplasms Palbociclib negatively regulates fatty acid synthesis due to upregulation of AMPKα and miR-33a levels to increase apoptosis in Panc-1 and MiaPaCa-2 cells. +genetics_knock down_promote 33537917 hsa-mir-498 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: HOTAIRM1 knockdown repressed cell glycolysis metabolism and tumor development by reducing ABCE1 expression through sponging miR-498 in NSCLC, which provided a theoretical basis for further studying NSCLC progression. +genetics_overexpression_promote 33537874 hsa-mir-145 Adenomyosis We found Talin1 was markedly overexpressed in ADS endometrial tissue and cells, whereas miR +lncRNA target 33537835 hsa-mir-411 Squamous Cell Carcinoma of Head and Neck In conclusion, the results of the present study indicated that the miR4115pmediated downregulation of RYBP expression levels may exert an important role in HNSCC metastasis and may provide a novel target for the treatment of HNSCC. +transcription factor target 33537828 hsa-mir-186 Osteoarthritis The present study aimed to investigate the effect of miR1865p in OA. In conclusion, the present results indicated that miR1865p could attenuate IL1betainduced chondrocyte inflammation damage by increasing MAPK1 expression, suggesting that miR1865p may be used as a potential therapeutic target for OA. +lncRNA target 33537823 hsa-mir-217 Osteosarcoma Therefore, the present study elucidated the potential mechanism of LINC00467 in OS and indicated that LINC00467 exerted its carcinogenic effects on OS through the miR217/KPNA4 axis, implying that LINC00467 may be a novel potential therapeutic target for OS. +exosome 33537818 hsa-mir-17 Nijmegen Breakage Syndrome Further experimentation revealed that the elevated expression of miR175p in SKNBE(2) cellderived exosomes significantly promoted the proliferative and migratory capacities of SHSY5Y cells by inhibiting PTEN. Collectively, these findings demonstrated that miR175p derived from MYCNamplified NB cell exosomes promoted the migration and proliferation of nonMYCN amplified cells, highlighting an exosomeassociated malignant role for miR175p. +exosome 33537818 hsa-mir-17 Chromosome Duplication Collectively, these findings demonstrated that miR175p derived from MYCNamplified NB cell exosomes promoted the migration and proliferation of nonMYCN amplified cells, highlighting an exosomeassociated malignant role for miR175p. +exosome 33537818 hsa-mir-17 Neuroblastoma Collectively, these findings demonstrated that miR175p derived from MYCNamplified NB cell exosomes promoted the migration and proliferation of nonMYCN amplified cells, highlighting an exosomeassociated malignant role for miR175p. +circRNA target 33537815 hsa-mir-346 Glioma In conclusion, the present study identified that circTOP2A promoted GM proliferation and aggressiveness via miR346/SUSD2 signaling, which is a potential prognostic biomarker and therapeutic target for GM. +lncRNA target 33537800 hsa-mir-125b Tuberculosis, Pulmonary Thus, it was suggested that miR125b served important roles in the occurrence and development of TB by decreasing the levels of IL6, TNFalpha, NFkappaB and IFNgamma by inhibiting RAF1. +other 33537240 hsa-mir-132 Colorectal Neoplasms A miR-132 mimic greatly hindered CRC cell proliferation. Moreover, our data indicated that miR-132 expression was greatly decreased in CRC samples, which was associated with longer survival times of CRC patients, implying that miR-132 was a probable biomarker for CRC. +other 33536877 hsa-mir-103 Parkinson Disease Thus, our results suggest that HMGA1 forms a negative feedback loop with miR-103/107-CDK5R1/CDK5 signaling to regulate the MPP(+)/MPTP-induced autophagy impairment and neural cell death. +genetics_knock down_suppress 33536789 hsa-mir-144 Stomach Neoplasms 5p inhibition or YWHAB overexpression effectively reversed the impacts of circ_0006282 knockdown on GC cell growth and motility. +other 33536788 hsa-mir-183 Osteosarcoma MiR-183-5p Promotes Tumor Progression of Osteosarcoma and Predicts Poor Prognosis in Patients. +target gene 33536787 hsa-mir-338 Osteosarcoma CircRNA hsa_circ_0005909 Promotes Cell Proliferation of Osteosarcoma Cells by Targeting miR-338-3p/HMGA1 Axis. +lncRNA target 33536786 hsa-mir-519d Stomach Neoplasms HCP5 exacerbated the resistance to cisplatin of GC cells in vitro by enhancing HMGA1 expression via sponging miR-519d. +transcription factor target 33536772 hsa-mir-34a Duane Retraction Syndrome CONCLUSION: Taken together, this work demonstrated that DHM exerts protective effects on HG-induced oxidative stress and apoptotic damage in ARPE-19 cells via inhibition of miR-34a expression, providing a promising therapeutic agent for the treatment of DR. +genetics_overexpression_promote 33536765 hsa-mir-21 Smooth Muscle Tumor CONCLUSION: In this study, overexpression of H19 suppressed the proliferation and migration of ASMCs induced by PDGF-BB via miR-21/PTEN/Akt axis, which could be a potential biomarker and target for treating hyperplasia of airway smooth muscle cells. +circulation_biomarker_diagnosis_ns 33536765 hsa-mir-21 Asthma RESULTS: LncRNA-H19 expression was decreased and microRNA-21 expression was increased in serum samples of children with asthma and PDGF-BB-stimulated ASMCs. +lncRNA target 33536761 hsa-mir-29c Colorectal Neoplasms CONCLUSION: These results revealed that LINC00511 participated in the progression of CRC by targeting the LINC00511/miR-29c-3p/NFIA axis, indicating that LINC00511 may be a potential therapeutic target for CRC treatment. +genetics_overexpression_suppress 33536745 hsa-mir-515 Nasopharyngeal Carcinoma 5p mimics following the overexpression of IL-25 in these same cells. +lncRNA target 33536579 hsa-mir-211 Triple Negative Breast Neoplasms SOX11 and NGN2 are the downstream targets of miR-211 and negatively regulate miR +lncRNA target 33536383 hsa-mir-20b Atherosclerosis This study aimed to elucidate the roles of miR-320b in cholesterol efflux from macrophages and the pathogenesis of atherosclerosis. CONCLUSION: We identify miR-320b as a novel modulator of macrophage cholesterol efflux and that it might be a promising therapeutic target for atherosclerosis treatment. +lncRNA target 33536061 hsa-mir-186 Pulmonary Fibrosis CONCLUSION: In conclusion, miR-186 delivered by BMSC-EVs suppressed SOX4 and DKK1 expression, thereby blocking fibroblast activation and ameliorating IPF, thus presenting a novel therapeutic target for IPF. +circulation_biomarker_diagnosis_down 33536058 hsa-mir-205 Chronic recurrent multifocal osteomyelitis Downregulation of miR-205 was also observed in DO-ECFCs and serum of animals undergoing MDO. +genetics_knock down_suppress 33536058 hsa-mir-205 Exostoses Autologous ECFCs transfected to knockdown miR-205 and were injected directly into the distraction callus. +genetics_overexpression_promote 33536026 hsa-mir-197 Breast Neoplasms 3p overexpression enhanced TAM resistance and promoted cell malignant biological behaviors in BC by targeting HIPK3. +lncRNA target 33536022 hsa-mir-31 Adenocarcinoma of Lung Furthermore, circ-ANXA7 could accelerate proliferation and invasion of LUAD cells by targeting miR-331. CONCLUSIONS: Our research identified a novel circ-ANXA7 for LUAD, which could facilitate proliferation, migration, and invasion of LUAD cells by miR-331/ LAD1 axis. +genetics_overexpression_suppress 33536018 hsa-mir-532 Colorectal Neoplasms 3p inhibited the biological functions of CRC cells, and overexpression of HMGA2 reversed the miR +other 33535997 hsa-mir-93 Small Cell Lung Carcinoma CONCLUSION: Therefore, LINC01116 might upregulate STA3 by sponging miR5p, thereby promoting cell invasion and migration in SCLC. +circulation_biomarker_diagnosis_ns 33535877 hsa-mir-183 Carcinoma, Non-Small-Cell Lung The levels of miR-183, miR-210 and miR-182 were significantly higher and miR-144 was significantly lower in HPV-DNA-positive NSCLC than those in HPV-DNA-negative NSCLC patients. Plasma miR-183, miR-210, miR-182 and miR-144 can be used as reliable biomarkers to identify circulating HPV-DNA-positive NSCLC. +circulation_biomarker_diagnosis_ns 33535877 hsa-mir-144 Carcinoma, Non-Small-Cell Lung The levels of miR-183, miR-210 and miR-182 were significantly higher and miR-144 was significantly lower in HPV-DNA-positive NSCLC than those in HPV-DNA-negative NSCLC patients. Plasma miR-183, miR-210, miR-182 and miR-144 can be used as reliable biomarkers to identify circulating HPV-DNA-positive NSCLC. +circulation_biomarker_diagnosis_ns 33535877 hsa-mir-182 Carcinoma, Non-Small-Cell Lung The levels of miR-183, miR-210 and miR-182 were significantly higher and miR-144 was significantly lower in HPV-DNA-positive NSCLC than those in HPV-DNA-negative NSCLC patients. Plasma miR-183, miR-210, miR-182 and miR-144 can be used as reliable biomarkers to identify circulating HPV-DNA-positive NSCLC. +other 33535837 hsa-mir-129 Acute Lung Injury CONCLUSION: Sufentanil regulated the miR5p/HMGB1 axis to enhance IkappaB-alpha expression, suggesting that sufentanil represents a candidate drug for ALI protection and providing avenues for clinical treatment. +other 33535553 hsa-mir-146b Carcinoma, Renal Cell 3p) and validated their expression in an independent sample set. +other 33535553 hsa-mir-424 Carcinoma, Renal Cell 3p) and validated their expression in an independent sample set. +other 33535553 hsa-mir-127 Carcinoma, Renal Cell 3p) and validated their expression in an independent sample set. +other 33535553 hsa-mir-200c Carcinoma, Renal Cell 3p) and validated their expression in an independent sample set. +other 33535553 hsa-mir-183 Carcinoma, Renal Cell 3p) and validated their expression in an independent sample set. +other 33535553 hsa-mir-139 Carcinoma, Renal Cell 3p) and validated their expression in an independent sample set. +other 33535553 hsa-mir-155 Carcinoma, Renal Cell 3p) and validated their expression in an independent sample set. +other 33535553 hsa-mir-210 Carcinoma, Renal Cell 3p) and validated their expression in an independent sample set. +other 33535487 hsa-mir-181a Breast Neoplasms A comparison of breast tumor versus healthy mammary tissues confirmed the important role of miR-181a-5p in ERalpha regulation and points to its putative predictive function in BC therapy. +other 33535226 hsa-mir-138 Neovascularization, Pathologic These results demonstrated that the circuitry involving miR-138 and SIRT1 may participate in vascular homeostasis and also offered the possibility of identifying a new approach in the treatment of angiogenic diseases. +circulation_biomarker_diagnosis_up 33535216 hsa-mir-126 Myasthenia Gravis RT-PCR technology was used to detect the relative expression of microRNA-126, microRNA-21, and FOXP3mRNA in peripheral blood mononuclear cells of the MG group and the control group. +circulation_biomarker_diagnosis_up 33535216 hsa-mir-21 Myasthenia Gravis RT-PCR technology was used to detect the relative expression of microRNA-126, microRNA-21, and FOXP3mRNA in peripheral blood mononuclear cells of the MG group and the control group. +genetics_knock down_promote 33535182 hsa-mir-299 Melanoma Wound healing and transwell invasion assays showed that MIR205HG knockdown decreased in vitro migration and invasiveness of melanoma cells, and these effects were reversed by treatment with miR +other 33535181 hsa-mir-21 Inflammatory Bowel Diseases 5p in feces of IBD patients have to guide significance for the noninvasive clinical diagnosis of IBD and have a warning effect on the occurrence of IBD-related colorectal cancer. +other 33535181 hsa-mir-16 Inflammatory Bowel Diseases 5p in feces of IBD patients have to guide significance for the noninvasive clinical diagnosis of IBD and have a warning effect on the occurrence of IBD-related colorectal cancer. +genetics_GWAS 33535172 hsa-mir-29a Glioma An in vitro study revealed an inhibitory role for miR-29a-3p in glioma cell migration and VM formation, and further study confirmed that ROBO1 is a direct target of miR-29a-3p. Overall, the present study demonstrates that MSCs can be used to produce miR-29a-3p-overexpressing exosomes, which have great potential for anti-VM therapy and may act as supplements to anti-angiogenetic therapy in the clinic. +circRNA target 33535081 hsa-mir-375 Arthritis, Rheumatoid These findings clarified that circ_AFF2 induced cell progression, inflammatory response in FLS-RA cells via the miR-375/TAB2 axis. +circRNA target 33534779 hsa-mir-409 Uterine Cervical Neoplasms CONCLUSIONS: circEPSTI1-miR-375/409-3P/515-5p-SLC7A11 axis affected the proliferation of cervical cancer via the competing endogenous RNAs (ceRNA) mechanism and was relative to ferroptosis. +circRNA target 33534779 hsa-mir-515 Uterine Cervical Neoplasms CONCLUSIONS: circEPSTI1-miR-375/409-3P/515-5p-SLC7A11 axis affected the proliferation of cervical cancer via the competing endogenous RNAs (ceRNA) mechanism and was relative to ferroptosis. +circRNA target 33534779 hsa-mir-375 Uterine Cervical Neoplasms CONCLUSIONS: circEPSTI1-miR-375/409-3P/515-5p-SLC7A11 axis affected the proliferation of cervical cancer via the competing endogenous RNAs (ceRNA) mechanism and was relative to ferroptosis. +lncRNA target 33534778 hsa-mir-141 Sarcopenia These findings suggest that inhibiting miR3p could be a therapeutic target for alleviating obesogenic sarcopenia. +lncRNA target 33534778 hsa-mir-141 Osteoporosis These findings suggest that inhibiting miR3p could be a therapeutic target for alleviating obesogenic sarcopenia. +genetics_knock down_promote 33534412 hsa-mir-495 Colorectal Neoplasms Rescue assay results confirmed that the inhibition effect of circ_0000372 knockdown on the proliferation and metastasis of CRC could be reversed by miR-495 inhibitor or IL6 overexpression. In short, we concluded that circ_0000372 promoted CRC progression by regulating the miR-495/IL6 axis, suggesting that circ_0000372 could be used as a new prognostic biomarker and therapeutic target for CRC. +transcription factor target 33534373 hsa-mir-141 Neuralgia 5p-alleviated neuropathic pain induced by OXA. +lncRNA target 33534059 hsa-mir-455 Nerve Degeneration In addition, sh-HOTAIR increased the level of miR3p, which further inhibited the expression of NLRP1 and the activation of NLRP1 inflammasome, thereby inhibiting neuronal pyroptosis. +lncRNA target 33534059 hsa-mir-455 Neurotoxicity Syndromes Our findings indicated that HOTAIR inhibited propofol-induced pyroptosis of neurons by regulating miR3p/NLRP1 axis, indicating that HOTAIR may be a potential therapeutic target for propofol-induced neurotoxicity. +genetics_knock down_promote 33534015 hsa-mir-522 Carcinoma, Non-Small-Cell Lung 3p was identified as a target of circ_0046264, and its deficiency reversed the effects of circ_0046264 knockdown to suppress malignant activities of NSCLC cells. +circulation_biomarker_diagnosis_ns 33533649 hsa-mir-92a Stomach Neoplasms These results showed that serum exosomal miR-92a-3p could be used as a novel new tumor biomarker to improve diagnostic efficiency in GC. +circulation_biomarker_diagnosis_down 33533580 hsa-mir-188 Polycystic Ovary Syndrome Firstly, peripheral blood samples were isolated from PCOS patients and healthy controls, and qRT-PCR analysis demonstrated a dramatic increase in miR-3188 in PCOS patients when compared to the healthy controls. +exosome 33533575 hsa-mir-451a Brain Ischemia CONCLUSION: Cerebral-IPC ameliorated cerebral I/R injury by inducing the release of exosomes containing miR-451a. +transcription factor target 33533530 hsa-mir-26a Stomach Neoplasms Downregulation of miR-26a-5p not only prevented GA-induced inhibition on GC cell growth, but also suppressed GA-induced apoptosis of GC cells. +circulation_biomarker_diagnosis_up 33533518 hsa-mir-210 Breast Neoplasms Receiver-operating characteristic curve analysis indicated that the serum miR +circulation_biomarker_diagnosis_up 33533518 hsa-mir-660 Breast Neoplasms Receiver-operating characteristic curve analysis indicated that the serum miR +genetics_overexpression_suppress 33533513 hsa-mir-21 Periodontitis CONCLUSION: Therefore, the expression levels of DCST1-AS1 are much lower in periodontitis patients compared to that in healthy controls, and overexpression of DCST1-AS1 can significantly elevate the expression of PLAP-1 by inhibiting miR-21 in PDLCs. +genetics_GWAS 33533479 hsa-mir-476a Aortic Valve Insufficiency Genetic modification of miR476a-RFL expression revealed that miR476a/RFL-mediated dynamic regulation of mitochondrial homeostasis influences AR formation in poplar. +lncRNA target 33532936 hsa-mir-27a Osteonecrosis The miR-27a expression profiles were found to be downregulated in ONFH samples and GC-induced hBMSCs using microarray analysis and real-time quantitative polymerase chain reaction, whereas the OD capacity of hBMSCs was significantly reduced in the GC group compared with the control group. In conclusion, miR-27a is thought to relieve ONFH and the OD repression in GC-induced hBMSCs by targeting the PI3K/Akt/mTOR pathway. +other 33532936 hsa-mir-27a Osteoporosis MicroRNA-27a (miR-27a) modulates osteogenic differentiation (OD); however, the mechanism by which it influences osteoclastic activity in the glucocorticoid (GC)-elicited osteoporotic bone is still unclear. +other 33532331 hsa-mir-518 bladder urothelial carcinoma miR-450, miR-518s, transcription factor PAX3, KRAS and PTEN were potential markers for outcomes of urothelial bladder carcinoma. +other 33532331 hsa-mir-450 bladder urothelial carcinoma miR-450, miR-518s, transcription factor PAX3, KRAS and PTEN were potential markers for outcomes of urothelial bladder carcinoma. +lncRNA target 33532183 hsa-mir-155 Liver Cirrhosis Collectively, our study indicates that YD reduces inflammation through the miR +genetics_overexpression_suppress 33532026 hsa-mir-133b Acute Lung Injury OBJECTIVE: We aimed to investigate the regulatory mechanism of miR-133b and Sp1 in rats with severe acute pancreatitis complicated by acute lung injury. CONCLUSION: Overexpression of miR-133b could inhibit Sp1 expression, thereby improving severe acute pancreatitis in rats and playing a protective role in acute lung injury. +genetics_overexpression_suppress 33532026 hsa-mir-133b Pancreatitis OBJECTIVE: We aimed to investigate the regulatory mechanism of miR-133b and Sp1 in rats with severe acute pancreatitis complicated by acute lung injury. CONCLUSION: Overexpression of miR-133b could inhibit Sp1 expression, thereby improving severe acute pancreatitis in rats and playing a protective role in acute lung injury. +genetics_knock down_suppress 33531993 hsa-mir-361 Carcinoma, Hepatocellular 3p knockdown hepatoma cells are more sensitive to cisplatin or sorafenib treatment. +genetics_overexpression_suppress 33531841 hsa-mir-924 Carcinoma, Hepatocellular POU3F2 was a direct target of miR-924, and miR-924 overexpression regulated DDP-resistant HCC cell progression and DDP resistance by down-regulating POU3F2. CONCLUSION: Our findings identified that circ_0031242 functioned as an important regulator in DDP-resistant HCC cell progression and DDP resistance through the miR-924/POU3F2 axis, illuminating circ_0031242 as a potential therapeutic target for the chemoresistant HCC. +genetics_knock down_promote 33531839 hsa-mir-1 Carcinoma, Renal Cell 5p upregulation was related to the function of circ_0035483 knockdown in RCC cells. +other 33531835 hsa-mir-185 Carcinoma, Non-Small-Cell Lung Circular RNA CircCDYL Regulates Proliferation and Apoptosis in Non-Small Cell Lung Cancer Cells by Sponging miR-185-5p and Upregulating TNRC6A. +lncRNA target 33531816 hsa-mir-134 Osteosarcoma Moreover, LINC01278 can suppress the proliferation and apoptosis of OS cells through mediating miR +genetics_overexpression_promote 33531648 hsa-mir-485 Stomach Neoplasms 3p overexpression could reverse the inhibitory effect of hsa_circ_0009172 on gastric cancer. +genetics_overexpression_promote 33531647 hsa-mir-375 Colorectal Neoplasms Overexpression of HLA-F-AS1 repressed miR-375 and promoted the PFN1 expression pattern in CRC cells and CRC-derived EVs, further promoting M2 polarization of macrophages. +lncRNA target 33531646 hsa-mir-384 Squamous Cell Carcinoma of Head and Neck Collectively, it can be concluded that SNHG17/miR-384/ELF1 axis contributed to OSCC cell growth via promoting CTNNB1 expression, thus activating Wnt/beta-catenin signaling pathway. +lncRNA target 33531645 hsa-mir-133a Squamous Cell Carcinoma of Head and Neck Taken together, we concluded that miR-133a acted as a tumor suppressor in OSCC through inhibition of the Notch signaling pathway via binding to CTBP2. +lncRNA target 33531596 hsa-mir-10b Breast Neoplasms Previously, we developed and tested an RNAi-targeted therapeutic, termed MN-anti-miR10b, which was designed to inhibit the critical driver of metastasis and metastatic colonization, miRNA-10b. +lncRNA target 33531596 hsa-mir-10b Brain Neoplasms Previously, we developed and tested an RNAi-targeted therapeutic, termed MN-anti-miR10b, which was designed to inhibit the critical driver of metastasis and metastatic colonization, miRNA-10b. +other 33531550 hsa-mir-20b Carcinoma, Pancreatic Ductal In contrast, levels of miR-30b-5p and miR-320b were significantly lower in PDAC as compared to CP and HC. +circulation_biomarker_diagnosis_up 33531104 hsa-mir-135a Alzheimer Disease The levels of ABCA1-labeled exosomal miR-135a increased in the CSF of MCI and DAT group compared to those of control group ( P < 0.05), slightly increased ( P > 0.05) in the serum of SCD patient group, and significantly increased in MCI and DAT patient groups compared to those of the control group ( P < 0.05). +lncRNA target 33531067 hsa-let-7b Leukemia, Myeloid, Acute Finally, we find that let-7b inhibits the proliferation of t(8;21) AML cell lines, rescues expression of AML1-ETO target genes, and promotes differentiation. +transcription factor target 33530998 hsa-mir-140 Arthritis, Rheumatoid 3p could inhibit cell viability and promote apoptosis of SFs in RA through targeting SIRT3. +other 33530981 hsa-mir-513a Triple Negative Breast Neoplasms CONCLUSIONS: Collectively, we elucidated a bona fide circNR3C2/miR-513a-3p/HRD1/Vimentin axis that negatively regulates the metastasis of TNBC, suggesting that circNR3C2 and HRD1 can act as potential prognostic biomarkers. +lncRNA target 33530902 hsa-mir-195 Duane Retraction Syndrome CONCLUSION: These results indicated that decreased SNHG16 accelerates oxidative stress-induced pathological angiogenesis in HMRECs by regulating the miR-195/mfn2 axis, providing a potential target for diabetic retinopathy (DR) therapy. +lncRNA target 33530902 hsa-mir-195 Diabetic Retinopathy CONCLUSION: These results indicated that decreased SNHG16 accelerates oxidative stress-induced pathological angiogenesis in HMRECs by regulating the miR-195/mfn2 axis, providing a potential target for diabetic retinopathy (DR) therapy. +other 33530884 hsa-mir-100 Chronic Disease OBJECTIVE: Thromboangiitis obliterans is a nonatherosclerotic segmental inflammatory disease, and miR-100 plays an anti-inflammatory role in chronic inflammation. +transcription factor target 33530884 hsa-mir-100 Thromboangiitis Obliterans These findings suggested that miR-100 might be a novel therapeutic target for the prevention of thromboangiitis obliterans. +other 33530884 hsa-mir-100 Cryopyrin-Associated Periodic Syndromes OBJECTIVE: Thromboangiitis obliterans is a nonatherosclerotic segmental inflammatory disease, and miR-100 plays an anti-inflammatory role in chronic inflammation. +lncRNA target 33530829 hsa-mir-340 Colonic Neoplasms 5p suppression and ATF1 upregulation. +genetics_GWAS 33530577 hsa-mir-335 Cystic Fibrosis 5p should be verified as a therapeutic strategy in CF caused by stop-codon mutation of the CFTR gene, this approach might give appreciable results in CF cells carrying other mutations impairing the processing or stability of CFTR protein, supporting its application in personalized therapy for precision medicine. +genetics_knock down_promote 33530159 hsa-mir-10a Multiple Myeloma The target genes of DEMs were predicted by the miRwalk 2.0 database and the hub genes were screened by constructing the protein-protein interaction (PPI) network, module analysis and overlapping with the differentially expressed genes (DEGs) after overexpression or knockout of miRNAs.Three downregulated DEMs were found to distinguish MM from normal and MM-MGUS controls in the GSE39571 dataset; one downregulated and one upregulated DEMs (hsa-miR-10a) could differentiate MM from normal and MM-MGUS controls in the GSE110271-GSE78865 merged dataset. +exosome 33530159 hsa-mir-16 Multiple Myeloma Furthermore, 11 downregulated (hsa-miR-16) and 1 upregulated DEMs were shared between GSE39571 and merged dataset when comparing MM with normal samples. Furthermore, EPHA8 was identified as a DEG that was downregulated in MM cells when the use of has-miR-10a mimics; while IGF1R, CCND1, CUL3, and ELAVL1 were also screened as DEGs that were upregulated in MM cells when silencing of hsa-miR-16.BMSCs-derived exosomal miR-10a and miR-16 may be involved in MM progression by regulating EPHA8 or IGF1R/CCND1/CUL3/ELAVL1, respectively. +lncRNA target 33530155 hsa-mir-21 Rhinitis, Allergic Furthermore, in AR patients, lncRNA NEAT1 was positively, while miR-21 and miR-125a was negatively associated with INSS (rhinorrhea, itching, congestion scores), TNSS and inflammatory cytokines; however, correlation of miR-124 with INSS, TNSS, and inflammatory cytokines was slight.LncRNA NEAT1 and its targets (miR-21 and miR-125a) present close correlations with disease risk, severity, and inflammation of AR, suggesting their potential as biomarkers for AR assessment. +lncRNA target 33530155 hsa-mir-124 Rhinitis, Allergic Furthermore, in AR patients, lncRNA NEAT1 was positively, while miR-21 and miR-125a was negatively associated with INSS (rhinorrhea, itching, congestion scores), TNSS and inflammatory cytokines; however, correlation of miR-124 with INSS, TNSS, and inflammatory cytokines was slight.LncRNA NEAT1 and its targets (miR-21 and miR-125a) present close correlations with disease risk, severity, and inflammation of AR, suggesting their potential as biomarkers for AR assessment. +lncRNA target 33530155 hsa-mir-125a Rhinitis, Allergic Furthermore, in AR patients, lncRNA NEAT1 was positively, while miR-21 and miR-125a was negatively associated with INSS (rhinorrhea, itching, congestion scores), TNSS and inflammatory cytokines; however, correlation of miR-124 with INSS, TNSS, and inflammatory cytokines was slight.LncRNA NEAT1 and its targets (miR-21 and miR-125a) present close correlations with disease risk, severity, and inflammation of AR, suggesting their potential as biomarkers for AR assessment. +lncRNA target 33530086 hsa-mir-637 Retinal Diseases The action of miR-637 on STAT3 may inhibit the proliferation and migration of retinal endothelial cells, providing a possible target for the treatment of HR. +other 33529914 hsa-let-7b Thrombocytopenia CONCLUSION: Let-7b-5p is a pro-survival miRNA in B cells and increased let-7b-5p is associated with enhanced surface BAFF-R in ITP. +other 33529861 hsa-mir-19b Carcinoma, Non-Small-Cell Lung Measurement of six NSCLC-related RNAs (miR-17, miR-155, TTF-1 mRNA, miR-19b, miR-210 and EGFR mRNA) shows the ability of the electrochemical CRISPR/CHDC system to be a fast, low-cost and highly accurate tool for early cancer diagnostics. +other 33529861 hsa-mir-155 Carcinoma, Non-Small-Cell Lung Measurement of six NSCLC-related RNAs (miR-17, miR-155, TTF-1 mRNA, miR-19b, miR-210 and EGFR mRNA) shows the ability of the electrochemical CRISPR/CHDC system to be a fast, low-cost and highly accurate tool for early cancer diagnostics. +other 33529861 hsa-mir-210 Carcinoma, Non-Small-Cell Lung Measurement of six NSCLC-related RNAs (miR-17, miR-155, TTF-1 mRNA, miR-19b, miR-210 and EGFR mRNA) shows the ability of the electrochemical CRISPR/CHDC system to be a fast, low-cost and highly accurate tool for early cancer diagnostics. +other 33529861 hsa-mir-17 Carcinoma, Non-Small-Cell Lung Measurement of six NSCLC-related RNAs (miR-17, miR-155, TTF-1 mRNA, miR-19b, miR-210 and EGFR mRNA) shows the ability of the electrochemical CRISPR/CHDC system to be a fast, low-cost and highly accurate tool for early cancer diagnostics. +genetics_knock down_promote 33529755 hsa-mir-501 Osteosarcoma 3p promotes osteoclastogenesis and aggravates bone loss. +genetics_knock down_promote 33529755 hsa-mir-501 Osteoporosis 3p promotes osteoclastogenesis and aggravates bone loss. +lncRNA target 33529652 hsa-mir-140 Alzheimer Disease Collectively, functional suppression of miR-140 enhanced autophagy and prevented mitochondrial dysfunction by upregulating PINK1, ultimately suggesting a novel therapeutic target for AD. +other 33529508 hsa-mir-181a Colonic Neoplasms CONCLUSIONS: The ANRIL negatively regulated radiosensitivity induced by COS in colon cancer cells by sponging miR-181a-5p. +lncRNA target 33529238 hsa-mir-4728 Breast Neoplasms 5p was further demonstrated to increase HER2 expression and promote cell proliferation and migration by directly inhibiting EBP1 in breast cancer. +other 33528807 hsa-mir-455 Ischemia SNHG15 contributed to OGD/R-induced neuron injury by regulating miR3p/TP53INP1 axis, which provided a novel insight to study lncRNA-directed therapy in ischemia stoke. +exosome 33528793 hsa-mir-7239 Glioma In summary, we found that miR3p in the glioma microenvironment is recruited to glioma cells by exosomes and inhibits Bmal1 expression. +other 33528317 hsa-mir-34a Multiple Myeloma microglobulin (beta2-MG) and more advanced international staging system (ISS) stage; miR-125a high expression associated with lower beta2-MG, less advanced ISS stage and less t (14; 16) abnormality; miR186 high expression associated with increased albumin; while miR-34a did not associate with any clinical features. +other 33528317 hsa-mir-186 Multiple Myeloma microglobulin (beta2-MG) and more advanced international staging system (ISS) stage; miR-125a high expression associated with lower beta2-MG, less advanced ISS stage and less t (14; 16) abnormality; miR186 high expression associated with increased albumin; while miR-34a did not associate with any clinical features. +other 33528317 hsa-mir-125a Multiple Myeloma microglobulin (beta2-MG) and more advanced international staging system (ISS) stage; miR-125a high expression associated with lower beta2-MG, less advanced ISS stage and less t (14; 16) abnormality; miR186 high expression associated with increased albumin; while miR-34a did not associate with any clinical features. +epigenetics 33527791 hsa-mir-148b Stomach Neoplasms CONCLUSION: This study demonstrated that HOTAIR interacts with miR-148b and DNMT1, eventually leading to PCDH10 methylation, which contributes to the progression of GC. +transcription factor target 33527765 hsa-mir-145 Prostatic Neoplasms TOP2A was screened as one of the target hub genes by PPI network analysis, which was adversely related to miRNA +other 33527539 hsa-mir-211 Alzheimer Disease NEW FINDINGS: What is the central question of this study? What is the mechanism of miR-211 in an Alzheimer's disease cell model? What is the main finding and its importance? miR-211 was upregulated in an Alzheimer's disease cell model. This study was intended to investigate the effect of miR-211 on an AD cell model and the involvement of neurogenin 2 (Ngn2). +other 33527017 hsa-mir-1254 Colorectal Neoplasms MiR-1254 and MEGF6 regulates oxaliplatin resistance in human colorectal cancer cells. +genetics_knock down_promote 33526470 hsa-let-7d Breast Neoplasms SIGNIFICANCE: These findings show that loss of miRNA let-7d and active HIF1 signaling promotes breast cancer brain metastasis via PDGF and that pharmacologic inhibition of PDGFR suppresses brain metastasis, suggesting novel therapeutic opportunities. +transcription factor target 33526055 hsa-mir-144 Carcinoma, Hepatocellular And re-expression of EIF4G2 could partially reverse the inhibiting effect of miR-144 in HCC. +genetics_knock down_suppress 33526047 hsa-mir-362 Ovarian Neoplasms Gain-of-function and loss-of-function methods were used to detect the effects of miR +lncRNA target 33526036 hsa-mir-15b Carcinoma, Non-Small-Cell Lung LncRNA MEG8 contributes to tumor growth of NSCLC via the miR-15a/b-5p/PSAT1 axis in vivo. +lncRNA target 33526036 hsa-mir-15a Carcinoma, Non-Small-Cell Lung LncRNA MEG8 contributes to tumor growth of NSCLC via the miR-15a/b-5p/PSAT1 axis in vivo. +genetics_overexpression_promote 33526034 hsa-mir-206 Atherosclerosis ASPH overexpression partly counteracted the effects induced by miR-206 overexpression in ox-LDL-induced THP +other 33526014 hsa-mir-20a Diabetes Mellitus, Type 1 CONCLUSION: TRG-AS1-miR-23b-PPM1L and GAS5-miR-320a-SERPINA1 regulatory axises might impact the pathogenesis of T1D. +other 33526014 hsa-mir-23b Diabetes Mellitus, Type 1 CONCLUSION: TRG-AS1-miR-23b-PPM1L and GAS5-miR-320a-SERPINA1 regulatory axises might impact the pathogenesis of T1D. +lncRNA target 33525948 hsa-mir-4429 Breast Neoplasms Moreover, RAB14 was a downstream target of miR-4429, and miR-4429 expression was negatively correlated with RAB14 or ILF3-AS1 expression in breast cancer tissues. +other 33525548 hsa-mir-5100 Pulmonary Eosinophilia Additionally, deregulation of miR-1246, miR-5100 and miR3p was observed in severe asthmatic patients after eight weeks of therapy, and a correlation was found between miR-1246 and eosinophil counts, including a number of exacerbations per year in these severe asthmatics. +other 33525548 hsa-mir-1246 Pulmonary Eosinophilia Additionally, deregulation of miR-1246, miR-5100 and miR3p was observed in severe asthmatic patients after eight weeks of therapy, and a correlation was found between miR-1246 and eosinophil counts, including a number of exacerbations per year in these severe asthmatics. +other 33525548 hsa-mir-338 Pulmonary Eosinophilia Additionally, deregulation of miR-1246, miR-5100 and miR3p was observed in severe asthmatic patients after eight weeks of therapy, and a correlation was found between miR-1246 and eosinophil counts, including a number of exacerbations per year in these severe asthmatics. +exosome 33525381 hsa-mir-210 Osteoarthritis 5p suppresses the oxygen consumption rate of chondrocytes, altering their bioenergetic state that is often observed in OA conditions. +exosome 33525381 hsa-mir-210 Cartilage Diseases 5p suppresses the oxygen consumption rate of chondrocytes, altering their bioenergetic state that is often observed in OA conditions. +other 33524877 hsa-mir-378h Periodontitis CONCLUSIONS: Our results suggested that circ_0081572 might prevent periodontitis by regulating the miR-378h /RORA axis. +other 33524569 hsa-mir-223 Syphilis 3p might singly or jointly be potential diagnostic biomarkers at different stages of syphilis. +other 33524569 hsa-mir-101 Syphilis Moreover, TRUST titer was significantly correlated with miR3p expression. +lncRNA target 33524272 hsa-mir-155 Inflammatory Bowel Diseases OBJECTIVE: The present study investigates the molecular mechanisms for effects of ART on UC, and the role of miR-155 in this process. CONCLUSION: ART reduced the inflammatory response by inhibiting the expression of miR-155 in UC to inhibit the NF-kappaB pathway. +lncRNA target 33523607 hsa-mir-29b Lung Injury The findings of this study collectively demonstrated that Rb3 exhibited its therapeutic effect during the treatment of SILI via modulating the H19/miR-29b-3p/HMBG1 signalling pathway. +other 33523578 hsa-mir-608 Ameloblastoma Hsa_circ_0089153/hsa-miR-608/EGFR p53 interaction pathway enrichment analysis confirmed functions mainly enriched in MAPK and related signaling pathways regulating AB progression. +transcription factor target 33523042 hsa-mir-181a Coronary Artery Disease Neutralizing miR-181a can be a viable and effective means to prevent cardiomyocyte from apoptosis in ischemic heart disease. +circulation_biomarker_diagnosis_ns 33522952 hsa-mir-361 Primary Myelofibrosis Along with a specific microRNA signature, the circulating EVs from TN patients are enriched with miR5p. +other 33522913 hsa-mir-183 Carcinoma, Basal Cell The analysis of a small RNA-seq data from Basal Cell Carcinomas (BCCs) using isomiR Window confirmed that miR5p is up-regulated in Nodular BCCs, but revealed that this effect was predominantly due to a novel 5'end variant. +transcription factor target 33522578 hsa-mir-24 Breast Neoplasms Our study suggested that metformin promotes ferroptosis of breast cancer by targeting the miR +exosome 33522393 hsa-mir-487a Stomach Neoplasms In conclusion, exosomal miR-487a derived from M2 macrophage promotes the proliferation and tumorigenesis in gastric cancer, and the novel findings might be helpful to the development of novel diagnostic and therapeutic methods in GC. +lncRNA target 33522355 hsa-mir-223 Thyroid Cancer, Papillary 3p inhibition or CXCR4 over-expression partly restored the proliferation, migration, and invasion activities of DUXAP8-downregulated PTC cells. +genetics_overexpression_promote 33522352 hsa-mir-124 Parkinson Disease 3p, and its overexpression weakens the impact of miR +other 33522065 hsa-mir-35 Osteosarcoma 3p axis participates in OS progression. +other 33521130 hsa-mir-424 Thyroid Cancer, Papillary The hsa-miR5p might have the potential to reverse the processes of papillary thyroid cancer by modulating the hub genes. +genetics_overexpression_promote 33520999 hsa-mir-505 Hemoglobinuria, Paroxysmal In addition, overexpression of miR-505 led to tumor growth inhibition in vivo, demonstrating that it acts as a tumor suppressor in PC. +genetics_overexpression_promote 33520987 hsa-mir-487a Colonic Neoplasms Interestingly, overexpression of circ_0020095 dramatically reversed the suppressive effects of miR-487a-3p mimics on CC cells. +circRNA target 33520980 hsa-mir-346 Osteoarthritis In conclusion, Circ0083429 regulates the ECM via the regulation of the downstream miRNA-346/SMAD3 in human chondrocytes, which provides a new therapeutic strategy for OA. +target gene 33520978 hsa-mir-202 Carcinoma, Hepatocellular Tumor-Suppressive Role of microRNA-202-3p in Hepatocellular Carcinoma Through the KDM3A/HOXA1/MEIS3 Pathway. +lncRNA target 33520966 hsa-mir-100 Necrobiotic Disorders CONCLUSION: Enriched miR5p in hucMSC-exo suppressed FOXO3 expression to inhibit NLRP3 inflammasome activation and suppress cytokine release and, therefore, protected cardiomyocytes from H/R-induced pyroptosis and injury. +lncRNA target 33520845 hsa-mir-34a Diabetes Mellitus, Type 2 Swimming training attenuates pancreatic apoptosis through miR-34a/Sirtu in1/P53 Axis in high-fat diet and Streptozotocin-induced Type-2 diabetic rats. +lncRNA target 33520845 hsa-mir-34 Diabetes Mellitus, Type 2 Swimming training attenuates pancreatic apoptosis through miR-34a/Sirtu in1/P53 Axis in high-fat diet and Streptozotocin-induced Type-2 diabetic rats. +circulation_biomarker_diagnosis_ns 33520826 hsa-mir-126 Diabetes Mellitus Purpose This study aims to investigate the effect of high-intensity interval training (HIIT) on gene expression of MicroRNA-126 (miR-126) and serum concentration of vascular endothelial growth factor/ sprouty related EVH1 domain containing 1/ rapidly accelerated fibrosarcoma 1 (VEGF/Spred-1/Raf-1) proteins effective in cardiac tissue angiogenesis of diabetic rats. +genetics_overexpression_promote 33520692 hsa-mir-144 Cholangiocarcinoma Overexpression of ST8SIA4 promoted the proliferation, invasion and migration of cholangiocarcinoma cells, and the changes were reversed by upregulating the expression of miR +genetics_overexpression_promote 33520692 hsa-mir-451a Cholangiocarcinoma Overexpression of ST8SIA4 promoted the proliferation, invasion and migration of cholangiocarcinoma cells, and the changes were reversed by upregulating the expression of miR +lncRNA target 33520365 hsa-mir-125a Glioblastoma Mechanistically, in vivo and in vitro studies demonstrated that circPARP4, as a miRNA sponge, directly interacted with miR-125a-5p, which then regulated FUT4 to exert the oncogenic effect on glioma behavior. Our findings illustrate functions of circPARP4 in modulating glioma progression through miR-125a-5p/FUT4 pathway, which provides a novel and potential target for glioma therapy. +lncRNA target 33520363 hsa-mir-644a Carcinoma, Non-Small-Cell Lung Here, we for the first time confirmed that miR-644a was downregulated and functioned as a tumor suppression gene in NSCLC. A circGLIS3/miR-644a/PTBP1 positive feedback loop exists in the tumorigenesis and development of NSCLC. +genetics_knock down_suppress 33520106 hsa-mir-155 Diabetic Nephropathies After TNC knockdown, the levels of TLR4, p-NF-kappaB p65, miR +other 33520084 hsa-mir-29b Fibrosis RESULTS: In comparison with the Ang-II group, miR-29b-3p was seen to lower the degree of atrial fibrosis, decrease the expression of fibrosis markers such as Collagen-I and a-SMA, and increase the protein expression of Cx43. CONCLUSIONS: MiR-29b-3p was able to reduce atrial structural and electrical remodeling in the study's rat fibrosis model. +lncRNA target 33519911 hsa-mir-3180 Carcinoma, Hepatocellular 3p; SNHG17 enhanced the progression of HCC via the miR +other 33519899 hsa-mir-145 Prostatic Neoplasms 5p/KLF5/AR axis were found to be putative mechanisms during PCa evolution. +lncRNA target 33519668 hsa-mir-375 Reperfusion Injury, Cerebral Ischemia Conclusion: Suppression of MALAT1 alleviates CI/RI of rats through regulating the miR-375/PDE4D axis. +other 33519353 hsa-mir-138-2 Alzheimer Disease 2 gene in modulating AD risk, possibly by acting on different biological pathways. +other 33519353 hsa-mir-138-2 torsion dystonia 1 We have previously identified copy number variations (CNVs) in microRNA genes in patients with EOAD, including a duplication of the MIR2 gene. +genetics_knock down_promote 33519236 hsa-mir-494 Lymphoma, Large B-Cell, Diffuse 3p or knockdown of FGFR2 removed the promoted effects of lncRNA SBF2-AS1 on DLBCL development. +genetics_overexpression_promote 33519234 hsa-mir-218 Carcinoma, Hepatocellular CONCLUSION: TRIM52-AS1 is overexpressed in HCC and can promote the proliferation and metastasis of HCC cells through miR +genetics_knock down_promote 33519212 hsa-mir-1193 Carcinoma, Squamous Cell, Cutaneous Moreover, miR-1193 was a direct target of circSEC24A and its downregulation reversed the inhibitory effect of circSEC24A knockdown on the progression of CSCC cells. +genetics_overexpression_suppress 33519190 hsa-mir-15b Breast Neoplasms Overexpression of miR-15b restored the growth and resistance of BC cells to 4-OHT. +other 33519139 hsa-mir-17 Esophageal Neoplasms Circular RNA AKT3 governs malignant behaviors of esophageal cancer cells by sponging miR-17-5p. +other 33518654 hsa-mir-1285 Atrial Fibrillation-Valvular Heart Disease KCNJ6, SNAP25, GJA5, BIRC5, hsa-miR3p, and lncRNA NPHP3-AS1 were likely to be associated with AF-VHD development. +lncRNA target 33517853 hsa-mir-34a Reperfusion Injury Metformin has been demonstrated to be beneficial for the treatment of an impaired myocardium as a result of ischemia/reperfusion (I/R) injury, and miR-34a may be involved in this process. Metformin also reduced apoptosis and the expression of apoptosis associated proteins, including caspase 3 and cleaved caspase, and decreased the expression of miR-34a, which is upregulated during I/R injury, which in turn resulted in corresponding changes in expression of Bcl-2, a direct target of miR-34a both in vitro and in vivo. +lncRNA target 33517826 hsa-mir-139 Carcinoma, Hepatocellular In conclusion, TTN-AS1 expression level is remarkably enhanced in HCC, and TTN-AS1 can promote the multiplication, migration, invasion, and EMT of HCC cells via regulating miR +genetics_knock down_promote 33517196 hsa-mir-410 Colorectal Neoplasms Functionally knockdown of ZCCHC10 or overexpression of miR +lncRNA target 33517190 hsa-mir-204 Diabetic Retinopathy Moreover, melatonin enhanced Sirt1 activity through the maternally expressed gene 3 (MEG3)/miR-204 axis, leading to the deacetylation of the Sirt1 target genes forkhead box o1 (Foxo1) and nuclear factor kappa B (NF-kappaB) subunit p65, eventually contribute to the alleviation of oxidative stress and inflammation. +other 33517149 hsa-mir-22 Diabetes, Gestational DISCUSSION: The upregulation of GLUT1 and HK2 in the placenta, which is induced by miR-9 and miR-22 reduction, contributes to the disordered glucose metabolism in patients with GDM. +other 33517149 hsa-mir-9 Diabetes, Gestational DISCUSSION: The upregulation of GLUT1 and HK2 in the placenta, which is induced by miR-9 and miR-22 reduction, contributes to the disordered glucose metabolism in patients with GDM. +circulation_biomarker_diagnosis_ns 33516900 hsa-mir-155 Burkitt Lymphoma Besides, a significant simple positive relationship (p < 0.05) was found between BLL and serum miR-155 expression levels. +circulation_biomarker_diagnosis_down 33516900 hsa-mir-126 Burkitt Lymphoma Additionally, a significant inverse correlation (p < 0.05) was determined between BLL and serum miR-126 expression levels, as downregulation of miR-126 expression levels was observed in highly exposed women. +lncRNA target 33516754 hsa-mir-124 Arthritis, Rheumatoid Ketoprofen, a non-steroidal anti-inflammatory drug, can effectively relieve pain associated with arthritis, and microRNA-124 (miR-124) can inhibit the progression of the disease. In conclusion, co-delivery of ketoprofen and miR-124 through NPs is a promising strategy for the treatment of arthritis. +genetics_knock down_promote 33516697 hsa-mir-520a Pre-Eclampsia CONCLUSION: Our study showed that MiR210HG is a novel upregulated lncRNA in the placentas of PE and MiR210HG regulates the migration and invasive potential of HTR-8/SVneo cell by targeting the miR-520a-3p/Dickkopf-1 axis. +other 33516697 hsa-mir-210 Pre-Eclampsia The aim of this study was to compare the lncRNAs transcript profile of placentae in early onset severe preeclampsia (EOSP) with lncRNAs in normal pregnancy (NP) and to evaluate the role of lncRNA MIR210HG (microRNA 210 host gene) in the PE pathogenesis. +circulation_biomarker_diagnosis_up 33516190 hsa-mir-146a Sarcopenia CONCLUSIONS: Myo-miRNA (c-miR-486) and inflammation-related miRNA (c-miR-146a) are superior to inflammatory peroxide/cytokines in plasma for serving as critical biomarkers of age-related sarcopenia. +circulation_biomarker_diagnosis_up 33516190 hsa-mir-486 Sarcopenia CONCLUSIONS: Myo-miRNA (c-miR-486) and inflammation-related miRNA (c-miR-146a) are superior to inflammatory peroxide/cytokines in plasma for serving as critical biomarkers of age-related sarcopenia. +other 33516048 hsa-mir-186 Inflammation RESULTS: We observed markedly increased infarct volume, neuronal apoptosis, inflammation and oxidative stress responses in the infarcted lesions of MCAO/R rats, in line with down-regulated levels of OIP5-AS1 and CTRP3 while up-regulated miR5p. +other 33516048 hsa-mir-186 Hypoxia-Ischemia, Brain RESULTS: We observed markedly increased infarct volume, neuronal apoptosis, inflammation and oxidative stress responses in the infarcted lesions of MCAO/R rats, in line with down-regulated levels of OIP5-AS1 and CTRP3 while up-regulated miR5p. +lncRNA target 33515913 hsa-mir-520a Osteosarcoma CONCLUSIONS: Our study first revealed that DEX inhibited malignancy of osteosarcoma cells via miR-520a-3p/YOD1 axis. +genetics_overexpression_suppress 33515898 hsa-mir-25 Carcinoma, Hepatocellular 3p overexpression inhibited angiogenesis of HCC. +other 33515696 hsa-mir-27 Metabolic Diseases In this study, we attempted to identify the mechanism by which miR-27 was regulated in the context of insulin resistance, a predisposed metabolic disorder in NAFLD. +genetics_overexpression_suppress 33515563 hsa-mir-326 Carcinoma, Non-Small-Cell Lung Propofol dose-dependently inhibited proliferation, migration and invasion while induced apoptosis of NSCLC cells, which was abolished by circ-RHOT1 overexpression, FOXM1 overexpression, or miR-326 silencing. +lncRNA target 33515562 hsa-mir-125b Non-alcoholic Fatty Liver Disease CONCLUSION: MiR-125b promoted the NF-kappaB-mediated inflammatory response in NAFLD by directly targeting TNFAIP3, and that mechanism might be target for treating NAFLD. +lncRNA target 33515560 hsa-mir-140 Encephalomyelitis, Autoimmune, Experimental SIGNIFICANCE: OIP5-AS1 contributed to EAE development by targeting miR5p/RhoA and activating RhoA/ROCK2 signaling pathway, shedding light on the roles and molecular mechanisms of OIP5-AS1 in the development of MS and providing some candidate targets for the diagnose and treatment of MS. +other 33515383 hsa-mir-195 Hirschsprung Disease 5p plays an important role in the pathogenesis of HSCR. +other 33515352 hsa-mir-362 Nervous System Diseases 3p) were confirmed to be related to neurological disorders. +lncRNA target 33515352 hsa-mir-362 Spinal Cord Injuries However, it is unclear whether SNHG1 was involved in the development of SCI via regulating miR3p. +lncRNA target 33515341 hsa-mir-15a Prostatic Neoplasms 1 can target the Bcl-2 gene and provide a cheap, applicable, cost-effective, and safe drug delivery system against prostate cancer. +lncRNA target 33515341 hsa-mir-16-1 Prostatic Neoplasms 1 can target the Bcl-2 gene and provide a cheap, applicable, cost-effective, and safe drug delivery system against prostate cancer. +other 33515273 hsa-mir-21 Lung Neoplasms Effective and simultaneous monitoring of the abnormal expression of certain microRNAs (miRNAs), especially for miRNA-21 and miRNA-155, can indicate drug resistance in lung cancer. A homogeneous T7 Exo-assisted signal amplification combined with GO quenching platform was developed for accurate, sensitive and simultaneous analysis of miRNA-21 and miRNA-155 for drug resistance warning in lung cancer. +other 33515273 hsa-mir-155 Lung Neoplasms Effective and simultaneous monitoring of the abnormal expression of certain microRNAs (miRNAs), especially for miRNA-21 and miRNA-155, can indicate drug resistance in lung cancer. A homogeneous T7 Exo-assisted signal amplification combined with GO quenching platform was developed for accurate, sensitive and simultaneous analysis of miRNA-21 and miRNA-155 for drug resistance warning in lung cancer. +lncRNA target 33514855 hsa-mir-708 Carcinoma, Hepatocellular Novel studies showed that miR-708 particularly targeted ZEB1 3'-UTR regions and inhibited the HCC cell proliferation, migration, and invasion. +lncRNA target 33514777 hsa-mir-182 Breast Neoplasms We present the involvement of gap junction in post-transcriptional axes and reveal Cx43/hsa_circ_0077755/miR-182 as a potential biomarker signature axis for heightened-risk of breast cancer initiation, and that its dysregulation patterns might predict prognosis along breast cancer initiation and progression. +other 33514560 hsa-mir-19b Reperfusion Injury, Renal Ischemia miR-17 approximately 92 is critical in the angiogenic response after renal IRI, which treatment with miR-18a and miR-19b mimics can mitigate. +circulation_biomarker_diagnosis_ns 33514560 hsa-mir-17 Reperfusion Injury, Renal Ischemia Specifically, miR-17 approximately 92(endo-/-) promotes renal tubular injury, reduces renal blood flow, promotes microvascular rarefaction, increases renal oxidative stress, and promotes macrophage infiltration to injured kidneys. +epigenetics 33514440 hsa-mir-129-2 Stomach Neoplasms 2-3p was significantly suppressed due to hypermethylation on its enhancer in EBVaGC. +genetics_overexpression_promote 33514309 hsa-mir-1 Stomach Neoplasms Overexpression of miR +circulation_biomarker_diagnosis_ns 33513887 hsa-mir-23a Colonic Neoplasms (4) Conclusions: High expression of circulating miR-323a-3p, miR5p, and miR-376a-3p was significantly associated with LN metastasis in colon cancer patients. +circulation_biomarker_diagnosis_ns 33513887 hsa-mir-382 Colonic Neoplasms (4) Conclusions: High expression of circulating miR-323a-3p, miR5p, and miR-376a-3p was significantly associated with LN metastasis in colon cancer patients. +circulation_biomarker_diagnosis_ns 33513887 hsa-mir-376a Colonic Neoplasms (4) Conclusions: High expression of circulating miR-323a-3p, miR5p, and miR-376a-3p was significantly associated with LN metastasis in colon cancer patients. +genetics_overexpression_promote 33513878 hsa-mir-675 Epidermodysplasia Verruciformis 5p in EVT cell invasion using the EVT cell lines HTR-8/SVneo and HChEpC1b; overexpression of miR +lncRNA target 33512745 hsa-mir-145 Stomach Neoplasms 5p is a direct target of NKX2 +circRNA target 33511909 hsa-mir-136 Carcinoma, Non-Small-Cell Lung 5p, illuminating a rationale for developing circ_0003998 as a therapeutic target of chemoresistant NSCLC. +other 33511814 hsa-mir-206 Asthma The RMRP/miR-206/CCL2 regulatory axis is implicated in the occurrence of pediatric asthma. +exosome 33511729 hsa-mir-433 Nasopharyngeal Carcinoma Here, we demonstrate that hypoxic adipocyte-derived exosomes are key information carriers that transfer low expression of miR +circulation_biomarker_diagnosis_ns 33511504 hsa-mir-22 Acute Kidney Injury CONCLUSION: Serum and urinary miR3p was reduced in sepsis-induced AKI patients, and served as a biomarker to predict AKI occurrence and 28-day survival in sepsis patients. +circulation_biomarker_diagnosis_ns 33511504 hsa-mir-22 Sepsis CONCLUSION: Serum and urinary miR3p was reduced in sepsis-induced AKI patients, and served as a biomarker to predict AKI occurrence and 28-day survival in sepsis patients. +lncRNA target 33511213 hsa-mir-4443 Carcinoma, Hepatocellular CONCLUSION: Collectively, we elucidated a role of lncRNAs-hsa-miRAKT1 pathway in response to baicalein treatment in HCC, which could help us understand the roles of baicalein in inhibiting cancer progression and may provide novel insights into the mechanisms behind HCC progression. +other 33511113 hsa-mir-548ah Small Cell Lung Carcinoma miRNA-548ah-5p of a high level acted as a negative role in the anticarcinogenic activity of curcumin. +lncRNA target 33510968 hsa-mir-582 Adenocarcinoma of Lung In addition, fresh cancer tissue samples and matched adjacent tissue samples from 12 LUAD patients were collected to verify the expression of miR-582's target genes in the model, further revealing the potential relationship between SOX9, RASA1, CEP55, MAP4K4 and LUAD tumorigenesis, and validating the predictive value of the model. +genetics_overexpression_suppress 33510945 hsa-mir-224 Atherosclerosis In summary, HDAC1 overexpression may enhance the anti-atherosclerotic and endothelial-protective effects of miR +exosome 33510944 hsa-mir-365a Cestode Infections We concluded that exosomal miR-365a-5p was effective in promoting osteogenesis and preventing the development of GIONFH via activation of the Hippo signaling pathway in rats. +exosome 33510943 hsa-mir-25 Colorectal Neoplasms Transfer of microRNA-25 by colorectal cancer cell-derived extracellular vesicles facilitates colorectal cancer development and metastasis. +target gene 33510812 hsa-mir-138 Stomach Neoplasms MCM3AP-AS1 promotes cisplatin resistance in gastric cancer cells via the miR-138/FOXC1 axis. +genetics_overexpression_promote 33510768 hsa-mir-193a Alzheimer Disease ACTG2 was also downregulated in human AD tissues and VMSCs overexpressing miR-193a-3p. +other 33510094 hsa-mir-132 Peripheral Nerve Injuries Expression levels of miR-21, miR-132, miR-29a, and miR-29b were robustly increased after sciatic nerve injury. +other 33510094 hsa-let-7 Peripheral Nerve Injuries Our findings reveal that multiple upstream miRNAs (i.e., let-7, miR-21, and miR-223) were associated with gene expression changes in rat sciatic nerve stumps after nerve injury, and these miRNAs play an important role in peripheral nerve regeneration. +other 33510094 hsa-mir-29b Peripheral Nerve Injuries Expression levels of miR-21, miR-132, miR-29a, and miR-29b were robustly increased after sciatic nerve injury. +other 33510094 hsa-mir-21 Peripheral Nerve Injuries Expression levels of miR-21, miR-132, miR-29a, and miR-29b were robustly increased after sciatic nerve injury. +other 33510094 hsa-mir-223 Peripheral Nerve Injuries Our findings reveal that multiple upstream miRNAs (i.e., let-7, miR-21, and miR-223) were associated with gene expression changes in rat sciatic nerve stumps after nerve injury, and these miRNAs play an important role in peripheral nerve regeneration. +other 33510094 hsa-mir-29a Peripheral Nerve Injuries Expression levels of miR-21, miR-132, miR-29a, and miR-29b were robustly increased after sciatic nerve injury. +transcription factor target 33509226 hsa-mir-1185-2 Breast Neoplasms We found that miRNA2-3p, the expression of which is decreased in human breast cancers and is inversely correlated with the prognosis of breast cancer patients, is directly involved in suppressing the expression of GOLPH3L. +circRNA target 33509213 hsa-mir-142 Glioma CONCLUSIONS: Circ_0000020 promotes glioma progression via miR +lncRNA target 33509040 hsa-mir-138 Insulin Resistance Amongst all, the expression level of miR-3138 was highest in the IR cell model evaluated by qRT-PCR. Our results showed that miR-3138 significantly deteriorated the IR of HUVECs via KSR2/AMPK/GLUT4 signaling pathway. +lncRNA target 33508876 hsa-mir-30 Inflammatory Bowel Diseases With the aim to investigate the regulatory effects of miR-330 on UC-related colon tissue damage and inflammation, a rat model of experimental colitis was established by oral administration of dextran sodium sulfate (DSS). In conclusion, we clarify the role of miR-330 in pathogenesis of UC, suggesting miR-330 alleviated DSS-induced colitis by downregulating IRAK1, shedding lights on miR-330 as a therapeutic candidate for UC treatment. +other 33508402 hsa-mir-149 Brain Ischemia 5p and Q10 can have a protective effect on the brain by reducing MMPs and inflammatory factors following cerebral ischemia and this could lead to a new treatment strategy to reduce the complications of cerebral ischemia. +other 33508384 hsa-mir-24 Pancreatic Carcinoma While the role of miR24 in cancer, including pancreatic carcinoma, has been described as ambiguous, it may hold great promise and deserves further studies. Here, we comprehensively analyze the effects of miR24-3p replacement in a set of pancreatic carcinoma cell lines. +other 33508370 hsa-mir-183 Diabetic Neuropathies 5p with high levels of accuracy could discriminate DN patients from healthy control (AUC = 0.836) and NEAT-1, SESN1, SESN3, ITGA4 have a high ability to distinguish DN from non-DN patients (AUC = 0.701, 0.772, 0.815 and 0.780, respectively). +other 33508370 hsa-mir-433 Diabetic Neuropathies Besides, the expression level of miR3p was significantly lower, and the mRNA expression of ITGA4, SESN1, and SESN3 was significantly higher in DN patients compared to the diabetes group. +lncRNA target 33508276 hsa-mir-190a Glioma miR-190a directly targeted NRG3 and inhibited the growth of canine glioma cells. +transcription factor target 33508041 hsa-mir-142 Cytomegalovirus Infections We constructed a recombinant MCMV encoding target sites for the hematopoietic specific miRNA miR3p in the essential viral gene IE3. +lncRNA target 33507713 hsa-mir-185 Breast Neoplasms Therefore, targeting the let-7d and miR-185/Rab25 interaction may offer new therapeutic opportunities for treating BC patients.
. +lncRNA target 33507713 hsa-let-7d Breast Neoplasms Therefore, targeting the let-7d and miR-185/Rab25 interaction may offer new therapeutic opportunities for treating BC patients.
. +other 33507707 hsa-mir-122 Nervous System Neoplasms The aim of this study was to the determination of the EBV infection frequency and the expression level of miR-122 and miR-BART in CNS tumors samples. +genetics_GWAS 33507700 hsa-mir-1307 Breast Neoplasms Association between Genetic Polymorphisms of miR-1307, miR- 1269, miR-3117 and Breast Cancer Risk in a Sample of South East Iranian Women. OBJECTIVE Examining the dependency of breast cancer risk with genetic polymorphisms of miR-1307, miR-1269, and miR-3117 in a sample of Iranian women (southeast region). +genetics_GWAS 33507700 hsa-mir-1269 Breast Neoplasms Association between Genetic Polymorphisms of miR-1307, miR- 1269, miR-3117 and Breast Cancer Risk in a Sample of South East Iranian Women. OBJECTIVE Examining the dependency of breast cancer risk with genetic polymorphisms of miR-1307, miR-1269, and miR-3117 in a sample of Iranian women (southeast region). +genetics_GWAS 33507700 hsa-mir-3117 Breast Neoplasms The current investigation revealed that miR-1307, miR-1269, and miR-3117 polymorphisms might play a crucial role in the Iranian population's vulnerability to BC.
. +circulation_biomarker_diagnosis_ns 33507694 hsa-mir-153 Squamous Cell Carcinoma of Head and Neck CONCLUSION: We conclude that miR153 and miR 455-5p expression in serum can function as a diagnostic screening test for the early detection of oral squamous cell carcinoma.
. +circulation_biomarker_diagnosis_ns 33507694 hsa-mir-455 Squamous Cell Carcinoma of Head and Neck CONCLUSION: We conclude that miR153 and miR 455-5p expression in serum can function as a diagnostic screening test for the early detection of oral squamous cell carcinoma.
. +transcription factor target 33507687 hsa-mir-145 Leukemia, Lymphocytic, Chronic, B-Cell 5p target the APRIL gene and might have a role in diagnosis of B-CLL. +transcription factor target 33507687 hsa-mir-185 Leukemia, Lymphocytic, Chronic, B-Cell 5p target the APRIL gene and might have a role in diagnosis of B-CLL. +tissue_expression_up 33507590 hsa-mir-423 Asthenozoospermia This study evaluated the sperm microRNA5p (miR5p) expression in asthenozoospermia and normozoospermia, exploring the role of miR5p in asthenozoospermia. Receiver operating characteristic curve (ROC) was employed to test the diagnostic performance of miR5p in asthenospermia. Results showed that the miR5p expression level in the AZS group was higher than that in Norm group, which was positively correlated with the severity of asthenozoospermia. In conclusion, the sperm miR5p level significantly was upregulated in asthenozoospermia. +other 33507382 hsa-mir-326 Multiple Sclerosis HNRNPA1 might play a central role in the pathogenesis of MS. +circulation_biomarker_diagnosis_ns 33507312 hsa-mir-152 Lupus Erythematosus, Systemic 3p expression profiles in CD4(+) T cells and peripheral blood mononuclear cells (PBMCs) harvested from patients with SLE and healthy controls, and analyzed the correlation between miR +other 33507228 hsa-mir-130a Grave Disease CONCLUSIONS: These data suggest that when Thy1- OFs accumulate in TED, miR-130a levels increase, leading to a decrease in AMPK activity. +genetics_overexpression_promote 33507136 hsa-mir-195 Glioblastoma Overexpression of RUNX1-IT1 and miR-195 was achieved in GBM cells to explore the interaction between them. CONCLUSIONS: RUNX1-IT1 may sponge miR-195 to upregulate cyclin D1, thereby increasing the proliferation of glioblastoma cells. +other 33507132 hsa-mir-34a Esophageal Neoplasms In vivo experiments revealed that the radiation resistance on ESCC was reversed by the introduction of miR-34a, the effect of which was promoted by the activation of SIRT1. +genetics_overexpression_promote 33507122 hsa-mir-489 Pancreatic Carcinoma Hsa_circ_0071036 was remarkably overexpressed in PDAC cell lines and tissue samples, which negatively correlated with miR-489 expression. +other 33506922 hsa-mir-495 Myocardial Infarction This article focused on the role of microRNA-495 (miR-495) in regulating apoptosis after myocardial infarction (MI) and its underlying mechanisms. +lncRNA target 33506921 hsa-mir-802 Myocardial Infarction 5p silencing could inhibit apoptosis after MI via activating Sonic Hedgehog signaling pathway by targeting PTCH1, thereby reducing myocardial injury and improving cardiac function of MI rats. +other 33506919 hsa-mir-6778 Myocardial Infarction, Acute 3p, and miRNA-520a-3p. +other 33506919 hsa-mir-6778 Coronary Artery Disease 3p, and miRNA-520a-3p. +lncRNA target 33506901 hsa-mir-155 Carcinoma, Non-Small-Cell Lung The mechanism was that DBH-AS1 regulated AXIN1 expression by sponging miR-155 in NSCLC cell lines. CONCLUSIONS: The progression of NSCLC is facilitated by DBH-AS1 via miR-155 interaction and up-regulation of AXIN1 expression. +lncRNA target 33506898 hsa-mir-365a Prostatic Neoplasms CONCLUSIONS: The findings of our work provided evidence that LINC00641 serves as a tumor suppressive lncRNA in PCa by regulating miR-365a-3p/VGLL4 axis. +lncRNA target 33506897 hsa-mir-217 Ovarian Neoplasms Effect and mechanism of miR-217 on drug resistance, invasion and metastasis of ovarian cancer cells through a regulatory axis of CUL4B gene silencing/inhibited Wnt/-catenin signaling pathway activation. OBJECTIVE To explore the effect and mechanism of miR-217 in cisplatin resistance, as well as invasion and metastasis of ovarian cancer by inhibiting the expression of Cullin 4B (CUL4B) and the activation of Wnt/-catenin signaling pathway. +genetics_overexpression_promote 33506893 hsa-mir-665 Spinal Cord Injuries Silenced miR-665 or overexpressed TREM2 was involved in protecting inflammatory response following SCI. +genetics_knock down_promote 33506890 hsa-mir-182 Tibial Fractures The knockdown of miR-182 might be a new method for treating fracture healing. +lncRNA target 33506742 hsa-mir-204 pancreatic adenocarcinoma 3p were proposed as 3 targets of LINC01232 in PAAD, and their decreased expression levels in PAAD patients showed certain clinical significance in diagnosis and prognosis. +lncRNA target 33506742 hsa-mir-370 pancreatic adenocarcinoma 3p were proposed as 3 targets of LINC01232 in PAAD, and their decreased expression levels in PAAD patients showed certain clinical significance in diagnosis and prognosis. +transcription factor target 33506649 hsa-mir-320c Osteoarthritis CONCLUSION: miR-320c inhibits articular chondrocyte proliferation and induces apoptosis by targeting MAPK1, suggesting that miR-320c perhaps participates in the pathogenesis of osteoarthritis and acts as a potential target for the therapeutic treatment of osteoarthritis. +circRNA target 33506582 hsa-mir-7 Lung Neoplasms CONCLUSIONS: Propofol inhibited lung cancer progression via mediating circ-ERBB2/miR +lncRNA target 33506255 hsa-mir-141 Diabetic Nephropathies To conclude, our study revealed that silencing of SNHG15 ameliorated the malignant behaviors of pediatric DN via modulating the miR-141/ICAM-1 axis in vitro. +other 33506118 hsa-mir-16a Neonatal Sepsis MiRNA- 16a could be considered as promising biomarkers for diagnosis of neonatal sepsis. +other 33506118 hsa-mir-16 Neonatal Sepsis MiRNA- 16a could be considered as promising biomarkers for diagnosis of neonatal sepsis. +circRNA target 33506107 hsa-mir-1301 Esophageal Squamous Cell Carcinoma 3p/COL1A1 axis, indicating that circ_0004370 may be used as a potential therapeutic target for EC. +lncRNA target 33506106 hsa-mir-137 Leukemia, Myeloid, Acute CONCLUSION: TRIM25 was targeted and regulated by miR-137, exerted a carcinogenic function in AML, and could be used as a latent biomarker and a treatment target for AML. +circulation_biomarker_diagnosis_down 33506046 hsa-mir-934 Asthma Finally, the levels of miR-3934 in PBMCs were negatively correlated with the serum levels of IL-6, IL-8, and IL-33 in asthma patients, respectively. +exosome 33505958 hsa-mir-410 Hypoxia-Ischemia, Brain Thus, we aimed to address the role of EV-derived microRNA (miR)-410 in HIBD. In summary, EV-derived miR-410 impeded neuronal apoptosis by elevating the expression of EGR2/Bcl2 via HDAC1 downregulation, thereby providing a potential strategy for treating or preventing HIBD. +other 33505907 hsa-mir-423 Colorectal Neoplasms Downregulation of miR-423-5p Contributes to the Radioresistance in Colorectal Cancer Cells. +target gene 33505778 hsa-mir-875 Esophageal Squamous Cell Carcinoma miR-875-5p exerts tumor-promoting function via down-regulation of CAPZA1 in esophageal squamous cell carcinoma. +lncRNA target 33505551 hsa-mir-145 Respiratory Distress Syndrome CONCLUSIONS: The miR-145 is down-regulated in LPS-induced ARDS, and affects its downstream genes targeting mitochondrial functions. +transcription factor target 33505436 hsa-mir-92a Nephritis, Interstitial The results of this study suggest that the inhibition of miR-92a-3p can alleviate TEC oxidative stress and pyroptosis by targeting Nrf1 in renal IRI. +transcription factor target 33505436 hsa-mir-92a Necrobiotic Disorders The aim of the present study was to determine the biological function and molecular mechanism of action of miR-92a-3p in tubular epithelial cell (TEC) pyroptosis. The results of this study suggest that the inhibition of miR-92a-3p can alleviate TEC oxidative stress and pyroptosis by targeting Nrf1 in renal IRI. +transcription factor target 33505436 hsa-mir-92a Iris Diseases The results of this study suggest that the inhibition of miR-92a-3p can alleviate TEC oxidative stress and pyroptosis by targeting Nrf1 in renal IRI. +lncRNA target 33505399 hsa-mir-106a Mycobacterium Infections The inhibitory effect of miR-106a on autophagy process during mycobacterial infection was also confirmed by Transmission Electron Microscope (TEM) observation. More importantly, forced expression of miR-106a increased mycobacterial survival, while transfection with miR-106a inhibitors attenuated the survival of intracellular mycobacteria. +transcription factor target 33505358 hsa-mir-145a Osteoporosis In summary, our results indicate that p53/miR-145a axis exert its functions both in promoting senescence and inhibiting osteogenesis of MSCs, and the novel p53/miR-145a/Cbfb axis in osteogenic differentiation of MSCs may represent new targets in the treatment of osteoporosis. +lncRNA target 33505213 hsa-mir-93 Sepsis We demonstrate that SNHG14 accelerates cellular injury in sepsis-induced AKI by activating IRAK4/NF-kappaB and IL-6R/STAT3 signaling via miR-93. +genetics_overexpression_suppress 33505161 hsa-mir-129 Uterine Cervical Neoplasms 5p overexpression reversed the impacts of HOTAIR on the malignant behaviors of propofol-treated CC cells. +other 33505117 hsa-mir-29b Myocardial Ischemia Our current research aimed to decipher the role and underlying mechanism with regard to miR-29b-3p involving in myocardial ischemia/reperfusion (I/R) injury. +circulation_biomarker_diagnosis_ns 33504764 hsa-mir-15b Memory Disorders In an asymptomatic at-risk population for AD, we show significant associations between plasma concentrations of miRNA-125b and miRNA-15b with core neuroimaging biomarkers of AD pathophysiology. +circulation_biomarker_diagnosis_ns 33504764 hsa-mir-125b Memory Disorders In an asymptomatic at-risk population for AD, we show significant associations between plasma concentrations of miRNA-125b and miRNA-15b with core neuroimaging biomarkers of AD pathophysiology. +other 33504681 hsa-mir-4469 Esophageal Squamous Cell Carcinoma The results indicated that circRNA_141539 served as an oncogenic factor in ESCC by sponging miR-4469 and activating CDK3 expression. +lncRNA target 33504438 hsa-mir-211 Melanoma MicroRNA miR-211 contributes to melanocyte and melanoma biology and has been implicated in targeted therapy resistance. +lncRNA target 33504414 hsa-mir-139 Asthma Objective To study the effects of microRNA-139 (miR-139) regulating Notch signaling pathway on bone mesenchymal stem cells (BMSCs) homing and asthma airway inflammation. Conclusion miR-139 can down-regulate the Notch pathway and promote BMSCs homing in asthmatic lung tissues, thus suppressing the inflammatory response of Th2 cells through immune regulation. +other 33504224 hsa-mir-224 Melanoma The levels of seven DEmRNAs (CXCR1, CXCR2, CXCR4, CCR1, CCR2, CCR5, and LIFR) and two DEmiRNAs (miR-203a-3p and miR5p) were validated using the GSE65568 and GSE109244 datasets, respectively.Conclusion: Our findings may provide novel biomarkers for CM metastasis.[Formula: see text]. +other 33504224 hsa-mir-203a Melanoma The levels of seven DEmRNAs (CXCR1, CXCR2, CXCR4, CCR1, CCR2, CCR5, and LIFR) and two DEmiRNAs (miR-203a-3p and miR5p) were validated using the GSE65568 and GSE109244 datasets, respectively.Conclusion: Our findings may provide novel biomarkers for CM metastasis.[Formula: see text]. +other 33504017 hsa-mir-150 Squamous Cell Carcinoma of Head and Neck We found that a combination of six miRNAs (miR-24, miR-20a, miR-122, miR-150, miR-4419a, and miR-5100) could distinguish between OSCC and the control group with a higher degree of accuracy (Area Under the Curve, AUC: 0.844, sensitivity: 55%, and specificity: 92.5%). +other 33504017 hsa-mir-20a Squamous Cell Carcinoma of Head and Neck We found that a combination of six miRNAs (miR-24, miR-20a, miR-122, miR-150, miR-4419a, and miR-5100) could distinguish between OSCC and the control group with a higher degree of accuracy (Area Under the Curve, AUC: 0.844, sensitivity: 55%, and specificity: 92.5%). +other 33504017 hsa-mir-5100 Squamous Cell Carcinoma of Head and Neck We found that a combination of six miRNAs (miR-24, miR-20a, miR-122, miR-150, miR-4419a, and miR-5100) could distinguish between OSCC and the control group with a higher degree of accuracy (Area Under the Curve, AUC: 0.844, sensitivity: 55%, and specificity: 92.5%). +other 33504017 hsa-mir-122 Squamous Cell Carcinoma of Head and Neck We found that a combination of six miRNAs (miR-24, miR-20a, miR-122, miR-150, miR-4419a, and miR-5100) could distinguish between OSCC and the control group with a higher degree of accuracy (Area Under the Curve, AUC: 0.844, sensitivity: 55%, and specificity: 92.5%). +other 33504017 hsa-mir-4419a Squamous Cell Carcinoma of Head and Neck We found that a combination of six miRNAs (miR-24, miR-20a, miR-122, miR-150, miR-4419a, and miR-5100) could distinguish between OSCC and the control group with a higher degree of accuracy (Area Under the Curve, AUC: 0.844, sensitivity: 55%, and specificity: 92.5%). +other 33504017 hsa-mir-24 Squamous Cell Carcinoma of Head and Neck We found that a combination of six miRNAs (miR-24, miR-20a, miR-122, miR-150, miR-4419a, and miR-5100) could distinguish between OSCC and the control group with a higher degree of accuracy (Area Under the Curve, AUC: 0.844, sensitivity: 55%, and specificity: 92.5%). +exosome 33503452 hsa-mir-215 Muscular Diseases modified exosomes may exert protective effects against skeletal muscle injury through the miR-215/FABP3 pathway and regulate the expression of CDKN1A, CCNB1, and TP53. +lncRNA target 33503444 hsa-mir-155 Liver Cirrhosis In conclusion, activation of the CB(2) receptors by AM1241 promoted liver regeneration and overrun the progression of liver fibrosis through; inhibition of TLR4/miR-155/NFkappaB p65 pathway, suppression of pro-inflammatory IL-6, IL-1beta and TNF-alpha, reducing TGF-beta1, alpha-SMA, Vimentin and up-regulating E-Cadherin. +lncRNA target 33503444 hsa-mir-155 Inflammation In conclusion, activation of the CB(2) receptors by AM1241 promoted liver regeneration and overrun the progression of liver fibrosis through; inhibition of TLR4/miR-155/NFkappaB p65 pathway, suppression of pro-inflammatory IL-6, IL-1beta and TNF-alpha, reducing TGF-beta1, alpha-SMA, Vimentin and up-regulating E-Cadherin. +lncRNA target 33503182 hsa-mir-195 Breast Neoplasms CONCLUSION: miRNA-195 is downregulated in the tumor tissues of Brazilian breast cancer patients regardless of NAC exposure; this reinforces its role as a tumor suppressor and a potential biomarker for chemotherapy response. +genetics_knock down_promote 33502949 hsa-mir-126 Carcinoma, Renal Cell HOTAIR knockdown and miR-126 overexpression suppressed the proliferation, migration, and angiogenesis of RCC cells. +genetics_knock down_promote 33502823 hsa-mir-186 Cholangiocarcinoma 5p reversed the effects of the knockdown of NEAT1. +other 33502747 hsa-mir-1244 Pre-Eclampsia In conclusion, the circUBAP2/miR-1244/FOXM1 axis might be a promising molecular marker for the diagnosis and treatment of PE. +transcription factor target 33502561 hsa-mir-24 Endometriosis APEX1/miR-24 axis: a promising therapeutic target in endometriosis. +circulation_biomarker_diagnosis_up 33501869 hsa-mir-133a Mucocutaneous Lymph Node Syndrome We intend to study the change of miRNA-133a in the plasma of patients with KD, explore the role of miRNA-133a on HUVEC and define the pathogenesis of vascular dysfunction in KD. +lncRNA target 33501823 hsa-mir-27 Lung Neoplasms In the present study, we identified a novel microRNA (miR)-27a as being involved in the radiosensitivity of lung cancer cells. Collectively, miR-27a activates HR-mediated DNA repair by inhibiting ZEB1 expression to enhance the radiosensitivity of lung cancer cells, highlighting a therapeutic target for lung cancer radiosensitivity. +lncRNA target 33501823 hsa-mir-27a Lung Neoplasms In the present study, we identified a novel microRNA (miR)-27a as being involved in the radiosensitivity of lung cancer cells. Collectively, miR-27a activates HR-mediated DNA repair by inhibiting ZEB1 expression to enhance the radiosensitivity of lung cancer cells, highlighting a therapeutic target for lung cancer radiosensitivity. +genetics_overexpression_promote 33501702 hsa-mir-145 Prostatic Neoplasms miR-145 overexpression in PCa cells induced the expression of SEMA3A at both messenger RNA and protein levels. +exosome 33501624 hsa-mir-21 Inflammation Our findings also reinforce the dual importance of exosomal miR-21 as a biomarker and therapeutic target in inflammatory conditions. +transcription factor target 33501603 hsa-mir-126 Obesity, Maternal These findings provide a novel mechanism by which obesity during pregnancy leads to increased risk of type 2 diabetes in the offspring and therefore identify miR3p as a potential therapeutic target. +transcription factor target 33501502 hsa-mir-34c Glioma Mechanistically, we proved that miR-34c negatively regulates PTP1B and then participates in the regulation of glioma cell proliferation in vivo. Collectively, these results suggested that miR-34c inhibits the proliferation of human glioma cells by targeting PTP1B, which will provide a potential target for the treatment of glioma. +circulation_biomarker_diagnosis_ns 33501488 hsa-mir-1264 Aortic Aneurysm, Abdominal Results showed that XIST expression was increased but miR-1264 expression level was reduced in the serum of AAA patients. Taken together, XIST impeded the apoptosis and stimulated the proliferation of HA-VSMCs via the WNT/beta-catenin signaling pathway through miR-1264, demonstrating XIST's underlying role in AAA. +lncRNA target 33500705 hsa-mir-155 Bulimia Nervosa Based on the results of the present study, miR-155 may serve as a novel diagnostic biomarker and therapeutic target for patients with BC. +circulation_biomarker_diagnosis_ns 33500702 hsa-mir-142 Uterine Cervical Neoplasms miR-142-3p reduces the viability of human cervical cancer cells by negatively regulating the cytoplasmic localization of HMGB1. +circulation_biomarker_diagnosis_ns 33500698 hsa-mir-33a Glomerulonephritis, IGA Hence, miR-33a-5p detected in the serum and urine may be used as a non-invasive biomarker to reflect the progression of renal injury and renal failure in patients with IgAN. +target gene 33500694 hsa-mir-361 Ovarian Neoplasms miR-361-5p regulates ovarian cancer cell proliferation and apoptosis by targeting TRAF3. +lncRNA target 33500693 hsa-mir-206 Polycystic Ovary Syndrome In conclusion, the findings of the present study suggested that miR-206 may serve an important role in PCOS through modulating ovarian granulosa cell viability and apoptosis. +genetics_overexpression_promote 33500664 hsa-mir-1 Glioblastoma In GBM cells, overexpression of circSKA3 increased the methylation of miR-1 gene and decreased the expression of miR-1. +other 33500653 hsa-mir-134 Thyroid Cancer, Papillary In addition, circRNA_104565 promoted cell proliferation in PTC by regulating the miR-134/ELF2 axis. +target gene 33500628 hsa-mir-503 Leukemia, Myeloid, Acute lncRNA RAET1K Promotes the Progression of Acute Myeloid Leukemia by Targeting miR-503-5p/INPP4B Axis. +target gene 33500627 hsa-mir-153 Thyroid Neoplasms MiR-153-3p Suppresses Cell Proliferation, Invasion and Glycolysis of Thyroid Cancer Through Inhibiting E3F3 Expression. +genetics_knock down_promote 33500625 hsa-mir-296 Colorectal Neoplasms CONCLUSION: Circ_0067835 knockdown suppressed CRC progression and enhanced CRC cell radiosensitivity partially by the miR +circulation_biomarker_diagnosis_ns 33500545 hsa-mir-424 Prostatic Neoplasms Here, we investigated the release of miR-424 in circulating small EVs or exosomes from prostate cancer patients and assessed the functional implications in multiple experimental models. We found higher frequency of circulating miR-424 positive EVs in patients with metastatic prostate cancer compared to patients with primary tumors and BPH. +genetics_overexpression_promote 33500536 hsa-mir-486 Lung Neoplasms 3p mimic reversed the effect of circFLNA overexpression on promoting lung cancer cells and tumors and regulating the expressions of miR +lncRNA target 33500406 hsa-mir-211 Carcinoma, Non-Small-Cell Lung Mechanically, SNHG18 exerted its prometastatic effects on NSCLC cells through repression of miR +other 33500384 hsa-mir-142 Carcinoma, Hepatocellular Clinically, TROAP was significantly upregulated by miR5p in HCC tissues, which predicted the poor survival of patients with HCC. +genetics_overexpression_suppress 33500248 hsa-mir-155 Carcinoma, Renal Cell Unlike lncTCL6, miR-155 was overexpressed in ccRCC. +lncRNA target 33499877 hsa-mir-942 Urinary Bladder Neoplasms 3p and GAS1 might be potential therapeutic targets for bladder cancer treatment. +lncRNA target 33499874 hsa-mir-568 Carcinoma, Hepatocellular Mechanism study revealed that LINC00680 regulated HCC stemness and chemosensitivity through sponging miR-568, thereby expediting the expression of AKT3, which further activated its downstream signaling molecules, including mTOR, elF4EBP1, and p70S6K. CONCLUSION: LINC00680 promotes HCC stemness properties and decreases chemosensitivity through sponging miR-568 to activate AKT3, suggesting that LINC00680 might be a potentially important HCC diagnosis marker and therapeutic target. +lncRNA target 33499725 hsa-mir-199a Intervertebral Disc Degeneration miR-199a carried by BMSCs-EVs promotes IDD repair by targeting GREM1 and downregulating the TGF-beta pathway. +genetics_overexpression_suppress 33499717 hsa-mir-137 Spinal Cord Injuries In vivo, miR-137 overexpression remarkably improved SCI symptoms, accompanied by obviously increased beta-Catenin expression and notably decreased KDM4A and SFRP4 expressions, while overexpressed KDM4A treatment showed the opposite trend in the presence of miR-137. CONCLUSION: We demonstrated that miR-137 targeted KDM4A and then downregulated SFRP4 to ameliorate SCI in a Wnt/beta-Catenin-dependent manner. +lncRNA target 33499704 hsa-mir-199a Stomach Neoplasms Our findings indicate that circ-ITCH suppresses metastasis of GC by acting as the sponge of miR-199a-5p and increasing Klotho expression, which serves as a potential biomarker and targets for the diagnosis and therapy of GC.Abbreviations: CircRNAs: circular RNAs; GC: gastric cancer; circ-ITCH: circular RNA Itchy E3 ubiquitin protein ligase; ceRNA: competitive endogenous RNA; EMT: Epithelial-mesenchymal transition; siRNA: Small interfering RNA; TEM: transmission electron microscope; NTA: nanoparticle tracking analysis. +other 33499244 hsa-mir-675 Carcinoma, Hepatocellular We propose that this regulation cascade can stimulate and enhance the inflammatory response in the liver, making miR-675 an important regulator in liver inflammation and potentially also in HCC. +lncRNA target 33498448 hsa-mir-186 Squamous Cell Carcinoma of Head and Neck When PTTG1 were downregulated in oral SCC cells treated with microRNA-186 and -655 inhibited their invasion abilities via MMP-9 activity. CONCLUSIONS: These results indicate that alteration of expression of PTTG1 in oral SCC cells by newly identified microRNA-186 and -655 can regulate invasion activity. +lncRNA target 33498448 hsa-mir-655 Squamous Cell Carcinoma of Head and Neck When PTTG1 were downregulated in oral SCC cells treated with microRNA-186 and -655 inhibited their invasion abilities via MMP-9 activity. CONCLUSIONS: These results indicate that alteration of expression of PTTG1 in oral SCC cells by newly identified microRNA-186 and -655 can regulate invasion activity. +other 33498271 hsa-mir-4284 Pancreatic Carcinoma 5p, we conducted quantitative reverse transcription PCR using samples from 17 independent PC patients, 8 ICC patients, and 8 healthy individuals. +other 33498271 hsa-mir-7145 Pancreatic Carcinoma 5p, we conducted quantitative reverse transcription PCR using samples from 17 independent PC patients, 8 ICC patients, and 8 healthy individuals. +other 33498271 hsa-mir-4703 Pancreatic Carcinoma 5p, we conducted quantitative reverse transcription PCR using samples from 17 independent PC patients, 8 ICC patients, and 8 healthy individuals. +other 33498271 hsa-mir-155 Pancreatic Carcinoma 5p, we conducted quantitative reverse transcription PCR using samples from 17 independent PC patients, 8 ICC patients, and 8 healthy individuals. +other 33498271 hsa-mir-4486 Pancreatic Carcinoma 5p, we conducted quantitative reverse transcription PCR using samples from 17 independent PC patients, 8 ICC patients, and 8 healthy individuals. +other 33498271 hsa-mir-22 Pancreatic Carcinoma 5p, we conducted quantitative reverse transcription PCR using samples from 17 independent PC patients, 8 ICC patients, and 8 healthy individuals. +other 33498271 hsa-let-7b Pancreatic Carcinoma 5p, we conducted quantitative reverse transcription PCR using samples from 17 independent PC patients, 8 ICC patients, and 8 healthy individuals. +transcription factor target 33498101 hsa-mir-205 Cicatrix, Hypertrophic At 12, 24, 36, and 48 h after transfection, the cell viability in miR-205 mimic group was significantly lower than that in miR-205 control group and miR-205 mimic+TSP-1 group (t=8.118, 26.970, 39.550, 42.490, 14.570, 12.240, 36.830, 45.220, P<0.05 or P<0.01). +circulation_biomarker_diagnosis_ns 33497805 hsa-mir-7 Carcinoma, Non-Small-Cell Lung Of note, we detected that miR-7 was significantly higher in serum exosomes from healthy controls than from patients with lung carcinoma, and high miR-7 expression was associated with strong response to lung carcinoma patients receiving gefitinib treatment, as well as a longer survival. +other 33497798 hsa-mir-20a fragile X-associated tremor/ataxia syndrome Overall, this work reveals an altered translocation of miRNAs to mitochondria and the role of miR-320a in FXTAS pathology. +circulation_biomarker_diagnosis_up 33497386 hsa-mir-133a Myocardial Ischemia NGS further yielded 52 DE miRNA in serum exosomes from CS versus AMI: 5 up-regulated in CS; 47 up-regulated in AMI, including transcripts previously detected in AMI patients (miR1, miR-133a, miR-208b, miR-423, miR-499). +circulation_biomarker_diagnosis_up 33497386 hsa-mir-423 Myocardial Infarction, Acute NGS further yielded 52 DE miRNA in serum exosomes from CS versus AMI: 5 up-regulated in CS; 47 up-regulated in AMI, including transcripts previously detected in AMI patients (miR1, miR-133a, miR-208b, miR-423, miR-499). +circulation_biomarker_diagnosis_up 33497386 hsa-mir-133a Myocardial Infarction, Acute NGS further yielded 52 DE miRNA in serum exosomes from CS versus AMI: 5 up-regulated in CS; 47 up-regulated in AMI, including transcripts previously detected in AMI patients (miR1, miR-133a, miR-208b, miR-423, miR-499). +circulation_biomarker_diagnosis_up 33497386 hsa-mir-499 Myocardial Infarction, Acute NGS further yielded 52 DE miRNA in serum exosomes from CS versus AMI: 5 up-regulated in CS; 47 up-regulated in AMI, including transcripts previously detected in AMI patients (miR1, miR-133a, miR-208b, miR-423, miR-499). +other 33497386 hsa-mir-624 Myocardial Infarction, Acute Five miRNAs with increased DE in CS included two isoforms of miR-624 and miR-144, previously reported as markers of cardiomyopathy. +other 33497386 hsa-mir-624 Myocardial Ischemia Five miRNAs with increased DE in CS included two isoforms of miR-624 and miR-144, previously reported as markers of cardiomyopathy. +circulation_biomarker_diagnosis_up 33497386 hsa-mir-423 Myocardial Ischemia NGS further yielded 52 DE miRNA in serum exosomes from CS versus AMI: 5 up-regulated in CS; 47 up-regulated in AMI, including transcripts previously detected in AMI patients (miR1, miR-133a, miR-208b, miR-423, miR-499). +circulation_biomarker_diagnosis_up 33497386 hsa-mir-208b Myocardial Infarction, Acute NGS further yielded 52 DE miRNA in serum exosomes from CS versus AMI: 5 up-regulated in CS; 47 up-regulated in AMI, including transcripts previously detected in AMI patients (miR1, miR-133a, miR-208b, miR-423, miR-499). +circulation_biomarker_diagnosis_up 33497386 hsa-mir-208b Myocardial Ischemia NGS further yielded 52 DE miRNA in serum exosomes from CS versus AMI: 5 up-regulated in CS; 47 up-regulated in AMI, including transcripts previously detected in AMI patients (miR1, miR-133a, miR-208b, miR-423, miR-499). +circulation_biomarker_diagnosis_up 33497386 hsa-mir-1-1 Myocardial Infarction, Acute NGS further yielded 52 DE miRNA in serum exosomes from CS versus AMI: 5 up-regulated in CS; 47 up-regulated in AMI, including transcripts previously detected in AMI patients (miR1, miR-133a, miR-208b, miR-423, miR-499). +other 33497386 hsa-mir-144 Myocardial Infarction, Acute Five miRNAs with increased DE in CS included two isoforms of miR-624 and miR-144, previously reported as markers of cardiomyopathy. +circulation_biomarker_diagnosis_up 33497386 hsa-mir-1-1 Myocardial Ischemia NGS further yielded 52 DE miRNA in serum exosomes from CS versus AMI: 5 up-regulated in CS; 47 up-regulated in AMI, including transcripts previously detected in AMI patients (miR1, miR-133a, miR-208b, miR-423, miR-499). +circulation_biomarker_diagnosis_up 33497386 hsa-mir-499 Myocardial Ischemia NGS further yielded 52 DE miRNA in serum exosomes from CS versus AMI: 5 up-regulated in CS; 47 up-regulated in AMI, including transcripts previously detected in AMI patients (miR1, miR-133a, miR-208b, miR-423, miR-499). +other 33497386 hsa-mir-144 Myocardial Ischemia Five miRNAs with increased DE in CS included two isoforms of miR-624 and miR-144, previously reported as markers of cardiomyopathy. +genetics_knock down_promote 33496921 hsa-mir-144 Stomach Neoplasms Moreover, the inhibitory effect of circ_0081146 knockdown on the progression of GC cells were reversed by silencing miR-144 or HMGB1 overexpression. +lncRNA target 33496636 hsa-mir-9 Carcinoma, Hepatocellular 5p/CPEB3 is expected to become a potential therapeutic target beneficial for HCC patients. +circulation_biomarker_diagnosis_ns 33496227 hsa-mir-4497 Malaria Relative expression of hsa-miR-4497 quantified by TaqMan-quantitative reverse transcription PCR was higher in plasma of children with SM than those with UM (p<0.048) and again correlated with P. +lncRNA target 33495842 hsa-mir-21 Carcinoma, Non-Small-Cell Lung These results indicated that MEG3 acted as a tumor suppressor that inhibited NSCLC cell migration and invasion via sponging miR215p, which, in turn, enhanced the expression levels of PTEN, in part via the PI3K/AKT signaling pathway. +lncRNA target 33495837 hsa-mir-583 Prostatic Neoplasms In conclusion, the findings of the present study suggested that miR583 may inhibit the proliferation and invasion of PCa cells by targeting JAK1, thus providing a novel therapeutic target for patients with PCa. +genetics_overexpression_suppress 33495832 hsa-mir-429 Colorectal Neoplasms In conclusion, overexpression of miR-429 may elevate the sensitivity of CRC cells to nintedanib through inhibition of the JNK signaling pathway by targeting DUSP4.These findings may aid in the prevention of drug resistance of CRC cells to nintedanib. +other 33495827 hsa-mir-140 Atherosclerosis 5p was highly expressed in the plaque-containing artery tissues of patients with AS compared with healthy control tissues. +genetics_overexpression_promote 33495824 hsa-mir-653 Breast Neoplasms Moreover, overexpression of miR6535p promoted cell apoptosis in breast cancer by regulating the Bcl2/Bax axis and caspase9 activation. +other 33495816 hsa-mir-455 Pulmonary Fibrosis The purpose of the present study was to investigate the roles of long noncoding RNA nuclear enriched abundant transcript 1 (NEAT1) and microRNA4553p (miR4553p) were investigated in pulmonary fibrosis. +transcription factor target 33495807 hsa-mir-409 Bronchopneumonia Suppression of miR4093p improved LPSinduced inflammation through SOCS3 in LPStreated BEAS2B cells, and this may be caused by regulating JAK1/STAT3 signaling. +lncRNA target 33495804 hsa-mir-10b Colorectal Neoplasms miR10b inhibitors partly attenuated siLINC00963induced inhibition of CRC cell proliferation, migration and invasion. Collectively, the results of the present study suggested a potential role of the LINC00963/miR-10b/FGF13 axis in the tumorigenesis and progression of CRC, indicating a novel lncRNA-based diagnostic or therapeutic target for CRC. +lncRNA target 33495420 hsa-mir-613 Triple Negative Breast Neoplasms Ultimately, miR-206/miR-613 inhibitor reversed impacts of si-hsa_circ_0000199 on PI3K/Akt/mTOR signaling, proliferation, migration, invasion, chemo-sensitivity and autophagy of TNBC cells (all P<0.01). +lncRNA target 33495420 hsa-mir-206 Triple Negative Breast Neoplasms Ultimately, miR-206/miR-613 inhibitor reversed impacts of si-hsa_circ_0000199 on PI3K/Akt/mTOR signaling, proliferation, migration, invasion, chemo-sensitivity and autophagy of TNBC cells (all P<0.01). +lncRNA target 33495342 hsa-mir-3 Atherosclerosis By elucidating the role of miR-33 in the liver and the impact of hepatic miR-33 deficiency on obesity and atherosclerosis, this work will help inform ongoing efforts to develop novel targeted therapies against cardiometabolic diseases. +genetics_knock down_promote 33495099 hsa-mir-1301 Stomach Neoplasms 3p silencing or PODXL overexpression could abolish the inhibitory effect of LINC01207 knockdown on GC cell growth and migration. +circulation_biomarker_diagnosis_ns 33495063 hsa-mir-34a Hypoxia Four blood samples (immediately before the intervention and 60-90 minutes, 24 hours, and 7 days after the intervention) were taken to measure the plasma concentrations of miRNAs related to hypoxia (miR-21 and miR-210), liver injury (miR-122), epithelial-mesenchymal transition (miR-200a), and apoptosis (miR-34a) using miRNA-specific TaqMan assays and quantitative real-time polymerase chain reaction. +circulation_biomarker_diagnosis_ns 33495063 hsa-mir-21 Hypoxia Four blood samples (immediately before the intervention and 60-90 minutes, 24 hours, and 7 days after the intervention) were taken to measure the plasma concentrations of miRNAs related to hypoxia (miR-21 and miR-210), liver injury (miR-122), epithelial-mesenchymal transition (miR-200a), and apoptosis (miR-34a) using miRNA-specific TaqMan assays and quantitative real-time polymerase chain reaction. +circulation_biomarker_diagnosis_ns 33495063 hsa-mir-200a Hypoxia Four blood samples (immediately before the intervention and 60-90 minutes, 24 hours, and 7 days after the intervention) were taken to measure the plasma concentrations of miRNAs related to hypoxia (miR-21 and miR-210), liver injury (miR-122), epithelial-mesenchymal transition (miR-200a), and apoptosis (miR-34a) using miRNA-specific TaqMan assays and quantitative real-time polymerase chain reaction. +circulation_biomarker_diagnosis_ns 33495063 hsa-mir-210 Chemical and Drug Induced Liver Injury Four blood samples (immediately before the intervention and 60-90 minutes, 24 hours, and 7 days after the intervention) were taken to measure the plasma concentrations of miRNAs related to hypoxia (miR-21 and miR-210), liver injury (miR-122), epithelial-mesenchymal transition (miR-200a), and apoptosis (miR-34a) using miRNA-specific TaqMan assays and quantitative real-time polymerase chain reaction. +circulation_biomarker_diagnosis_ns 33495063 hsa-mir-34a Chemical and Drug Induced Liver Injury Four blood samples (immediately before the intervention and 60-90 minutes, 24 hours, and 7 days after the intervention) were taken to measure the plasma concentrations of miRNAs related to hypoxia (miR-21 and miR-210), liver injury (miR-122), epithelial-mesenchymal transition (miR-200a), and apoptosis (miR-34a) using miRNA-specific TaqMan assays and quantitative real-time polymerase chain reaction. +circulation_biomarker_diagnosis_ns 33495063 hsa-mir-122 Hypoxia Four blood samples (immediately before the intervention and 60-90 minutes, 24 hours, and 7 days after the intervention) were taken to measure the plasma concentrations of miRNAs related to hypoxia (miR-21 and miR-210), liver injury (miR-122), epithelial-mesenchymal transition (miR-200a), and apoptosis (miR-34a) using miRNA-specific TaqMan assays and quantitative real-time polymerase chain reaction. +circulation_biomarker_diagnosis_ns 33495063 hsa-mir-200a Chemical and Drug Induced Liver Injury Four blood samples (immediately before the intervention and 60-90 minutes, 24 hours, and 7 days after the intervention) were taken to measure the plasma concentrations of miRNAs related to hypoxia (miR-21 and miR-210), liver injury (miR-122), epithelial-mesenchymal transition (miR-200a), and apoptosis (miR-34a) using miRNA-specific TaqMan assays and quantitative real-time polymerase chain reaction. +circulation_biomarker_diagnosis_ns 33495063 hsa-mir-21 Chemical and Drug Induced Liver Injury Four blood samples (immediately before the intervention and 60-90 minutes, 24 hours, and 7 days after the intervention) were taken to measure the plasma concentrations of miRNAs related to hypoxia (miR-21 and miR-210), liver injury (miR-122), epithelial-mesenchymal transition (miR-200a), and apoptosis (miR-34a) using miRNA-specific TaqMan assays and quantitative real-time polymerase chain reaction. +circulation_biomarker_diagnosis_ns 33495063 hsa-mir-210 Hypoxia Four blood samples (immediately before the intervention and 60-90 minutes, 24 hours, and 7 days after the intervention) were taken to measure the plasma concentrations of miRNAs related to hypoxia (miR-21 and miR-210), liver injury (miR-122), epithelial-mesenchymal transition (miR-200a), and apoptosis (miR-34a) using miRNA-specific TaqMan assays and quantitative real-time polymerase chain reaction. +circulation_biomarker_diagnosis_ns 33495063 hsa-mir-122 Chemical and Drug Induced Liver Injury Four blood samples (immediately before the intervention and 60-90 minutes, 24 hours, and 7 days after the intervention) were taken to measure the plasma concentrations of miRNAs related to hypoxia (miR-21 and miR-210), liver injury (miR-122), epithelial-mesenchymal transition (miR-200a), and apoptosis (miR-34a) using miRNA-specific TaqMan assays and quantitative real-time polymerase chain reaction. +circulation_biomarker_prognosis_up 33494814 hsa-mir-613 Breast Neoplasms 3p level was also dramatically lower in tumor tissues or serum of breast cancer patients. +other 33494806 hsa-mir-25 Breast Neoplasms 3p and MEK4/JNK1 regulatory axes. +lncRNA target 33494773 hsa-mir-155 Breast Neoplasms CONCLUSIONS: Considering clinical trials targeting PGE2 production largely have focused on the inhibition of Cox1 or Cox2 that showed cardiac toxicity, our data suggest an alternative way for suppressing PGE2 production via the inhibition of miR-155. +genetics_knock down_promote 33494763 hsa-mir-433 Carcinoma, Non-Small-Cell Lung CONCLUSION: Hsa_circ_0010235 knockdown suppressed NSCLC progression by regulating miR +circulation_biomarker_diagnosis_ns 33494641 hsa-mir-34b Sepsis METHODS: Serum levels of miR-34b-5p, TNF-alpha, IL-1beta, IL-6, serum creatinine (SCr), and blood urea nitrogen (BUN) in septic patients with acute kidney injury (AKI) and healthy controls were detected. RESULTS: The expression of miR-34b-5p and the inflammatory responses were augmented in septic AKI patients. +circulation_biomarker_diagnosis_ns 33494641 hsa-mir-34b Acute Kidney Injury METHODS: Serum levels of miR-34b-5p, TNF-alpha, IL-1beta, IL-6, serum creatinine (SCr), and blood urea nitrogen (BUN) in septic patients with acute kidney injury (AKI) and healthy controls were detected. RESULTS: The expression of miR-34b-5p and the inflammatory responses were augmented in septic AKI patients. +lncRNA target 33494069 hsa-mir-199a Parkinson Disease In summary, the results of the present study showed that lncRNA XIST sponges miR-199a-3p to modulate Sp1 expression and further accelerates Parkinson's disease progression by targeting LRRK2. +circulation_biomarker_diagnosis_ns 33493854 hsa-mir-19b Medulloblastoma The sensor showing the best performance, is subsequently used for the Cas13a-powered proof-of-concept measurement of two miRNAs (miRNA-19b and miRNA-20a) from the miRNA92 cluster, which is dysregulated in the blood of pediatric medulloblastoma patients. +genetics_overexpression_promote 33493581 hsa-mir-96 Parkinson Disease miR-96 overexpression promoted MPP(+)-induced neuronal injury via decreasing BNIP3. +lncRNA target 33493421 hsa-mir-186 Triple Negative Breast Neoplasms Conclusion: UA promotes TNBC cell sensitivity to DOX through inactivating ZEB1-AS1/miR5p/ABCC1 signaling. +genetics_overexpression_promote 33493419 hsa-mir-22 Colorectal Neoplasms Overexpression of MIR22HG inhibited the growth, migration ability, and invasiveness of CRC cell in vitro. +lncRNA target 33493418 hsa-mir-19a Adenocarcinoma of Lung Conclusion: This research demonstrated that an interactome existed between miR-19a-3p and TEK and that miR-19a-3p could suppress LUAD tumors by inhibiting TEK. +lncRNA target 33493381 hsa-mir-1908 Uterine Cervical Neoplasms In conclusion, our findings indicated that miR-1908 targets HDAC10 in cervical cancer and regulates aggressive cervical cancer cell phenotypes. +circulation_biomarker_diagnosis_up 33493140 hsa-mir-423 Breast Neoplasms RESULTS: The expression of serum and exosomal hsa-miR +lncRNA target 33493131 hsa-mir-655 Cystadenocarcinoma, Serous, Ovarian Thus, combined with diversified bioinformatic analyses, BUB1B, NDC80, TFAP2A, ELF3 and hsa-miR-655 may act as the key biomarkers for early clinical diagnosis and prognosis evaluation of OSC patients as well as potential therapeutic target-points. +other 33493087 hsa-mir-326 Breast Neoplasms 5p expression levels were differentially expressed in MT development and in ageing. +other 33493087 hsa-mir-129 Breast Neoplasms 5p expression levels were differentially expressed in MT development and in ageing. +other 33493087 hsa-mir-500 Breast Neoplasms 5p expression levels were differentially expressed in MT development and in ageing. +genetics_overexpression_promote 33492555 hsa-mir-708 Inflammation Overexpression of miR +genetics_overexpression_promote 33492555 hsa-mir-708 Myocardial Infarction Overexpression of miR +lncRNA target 33492448 hsa-mir-34a Colorectal Neoplasms Consequently, the in vivo inhibitory activity of miR-34a on colorectal cancer (CRC) was eradicated by the reinforced B7-H3 and TNF-alpha. In conclusion, our study uncovered an etiological mechanism underlying miR-34a-mediated CRC immune evasion through inhibition of SIRT1 and promotion of NF-kappaB/B7-H3/TNF-alpha axis. +other 33492037 hsa-mir-380 Diabetic Neuropathies Our analyses identify miR-33 and miR-380 expressed in nociceptive neurons as critical denominators of diabetic pain and miR1 as a mediator of physiological nociception. +other 33492037 hsa-mir-124-1 Diabetic Neuropathies Our analyses identify miR-33 and miR-380 expressed in nociceptive neurons as critical denominators of diabetic pain and miR1 as a mediator of physiological nociception. +other 33492037 hsa-mir-3 Diabetic Neuropathies Our analyses identify miR-33 and miR-380 expressed in nociceptive neurons as critical denominators of diabetic pain and miR1 as a mediator of physiological nociception. +genetics_knock down_promote 33491971 hsa-mir-133a Ovarian Neoplasms Moreover, rescue experiments indicated that the effects caused by ABHD11-AS1 knockdown on the malignant characteristics of ovarian cancer cells were notably enhanced by miR-133a-3p mimics, whereas the influences on cell growth and metastasis induced by overexpressed ABHD11-AS1 were abrogated by the restoration of miR-133a-3p expression. +circulation_biomarker_diagnosis_ns 33491845 hsa-mir-425 Ischemic Stroke 5p/SIRT1/NF-kappaB axis plays a critical role in the regulation of cerebral ischemia-induced microglial inflammation and brain-blood barrier damage. +lncRNA target 33491760 hsa-mir-340 Cholangiocarcinoma In conclusion, the present study indicated that aspirin partially inhibited cholangiocarcinoma cell proliferation and tumor growth by inducing G0/G1 phase cell cycle arrest, potentially through the miR3405p/cyclin D1 axis. +circulation_biomarker_diagnosis_up 33491670 hsa-mir-153 Hypertriglyceridemia Using miRNA sequencing and further verification, we found that miRNA-153 (miR-153) was upregulated in the pancreas of HTG animal models and in the plasma of patients with HTG-AP. +circulation_biomarker_diagnosis_up 33491670 hsa-mir-153 Pancreatitis Using miRNA sequencing and further verification, we found that miRNA-153 (miR-153) was upregulated in the pancreas of HTG animal models and in the plasma of patients with HTG-AP. +circulation_biomarker_diagnosis_ns 33491425 hsa-mir-1 Colorectal Neoplasms Plasma miR-1 levels in CRC samples were significantly higher than those in control samples, whereas EV miR-1 levels were not statistically different. CONCLUSIONS: Our data indicate that plasma miR-1, but not EV miR-1, could function as a potential biomarker for CRC diagnosis. +lncRNA target 33491285 hsa-mir-182 Myocardial Reperfusion Injury To sum up, our results suggested that CHRF exacerbated myocardial I/R injury by enhancing autophagy via modulation of the miR5p/ATG7 pathway. +lncRNA target 33491257 hsa-mir-374a Inflammation CONCLUSIONS: Our findings indicate that LINC02288 contributes to OA progression by targeting the miR-374a-3p/RTN3 axis, which might provide a promising molecular therapy strategy for OA. +lncRNA target 33491221 hsa-mir-34a Inflammation These data suggest that HPE can inhibit oxidative damage, inflammation, and apoptosis through the AMPK/SIRT1/NF-kappaB pathway, and decrease miR-34a/SIRT1/p53 pathway activation in ARPE-19 cells, thereby demonstrating a potential use as a food additive to mitigate hyperglycemia-induced retinal damage. HPE also inhibited the AMPK/SIRT1/NF-kappaB and miR-34a/SIRT1/p53 pathways, which are involved in hyperglycemia-induced inflammation and apoptosis of ARPE-19 cells by regulating acetylation. +lncRNA target 33491221 hsa-mir-34a Retinal Diseases These data suggest that HPE can inhibit oxidative damage, inflammation, and apoptosis through the AMPK/SIRT1/NF-kappaB pathway, and decrease miR-34a/SIRT1/p53 pathway activation in ARPE-19 cells, thereby demonstrating a potential use as a food additive to mitigate hyperglycemia-induced retinal damage. +lncRNA target 33491221 hsa-mir-34a Hyperglycemia These data suggest that HPE can inhibit oxidative damage, inflammation, and apoptosis through the AMPK/SIRT1/NF-kappaB pathway, and decrease miR-34a/SIRT1/p53 pathway activation in ARPE-19 cells, thereby demonstrating a potential use as a food additive to mitigate hyperglycemia-induced retinal damage. HPE also inhibited the AMPK/SIRT1/NF-kappaB and miR-34a/SIRT1/p53 pathways, which are involved in hyperglycemia-induced inflammation and apoptosis of ARPE-19 cells by regulating acetylation. +circulation_biomarker_diagnosis_ns 33491014 hsa-mir-21 Lung Neoplasms Most importantly, the biosensor was then applied for the accurate quantitative detection of miRNA-21 in exosome lysates extracted from human plasma and this method was able to successfully distinguish lung cancer patients from healthy people. +other 33490646 hsa-mir-424 Rickettsia Infections rickettsii-infected HMECs, we further explored the possibility of regulation of CX3CL1 expression during rickettsial infection by miR-424. +genetics_knock down_suppress 33490282 hsa-mir-124 Reperfusion Injury CONCLUSION: Knockdown of SNHG14 alleviated I/R-induced AKI by miR3p-mediated downregulation of MMP2. +other 33490270 hsa-mir-296 Norrie disease 5p in NRDS. +transcription factor target 33490245 hsa-mir-3913 Cholangiocarcinoma 5p might be an oncogene that affects the proliferation and migration of CCA cells by inhibiting and mimicking miR +other 33490232 hsa-mir-124 Breast Neoplasms The focus of this study was to explore the influence of Kruppel-like factor 3 (KLF3), tumor protein D52 (TPD52), microRNA 124 (miR-124), and protein kinase C epsilon (PKCepsilon) expression on breast cancer. +genetics_overexpression_promote 33490163 hsa-mir-146b Acute Lung Injury By mediating the overexpression of miR-146b-5p, FOXP3 also increased alveolar clearance and inhibited inflammatory responses in the ALI model. +transcription factor target 33490151 hsa-mir-126 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: MiR-126 plays an essential role in the biological processes of NSCLC through binding to target genes and influences the prognosis of patients with the disease. +target gene 33490150 hsa-mir-326 Uterine Cervical Neoplasms miR-326 inhibits the cell proliferation and cancer stem cell-like property of cervical cancer in vitro and oncogenesis in vivo via targeting TCF4. +other 33490119 hsa-mir-29c Liver Cirrhosis Results: According to microarray analysis, 50 miRNAs were found to be significantly abundant in UVH patients of which miR-29b-3p and miR-29c-3p were significantly related to the model of end-stage liver disease (MELD)-Albumin and albumin-bilirubin (ALBI) score representing advanced liver fibrosis/cirrhosis. Conclusions: In UVH patients with and without Fontan palliation, miR-29b-3p and miR-29c-3p seem to be markers of advanced liver fibrosis/cirrhosis and thus may be used in the risk assessment of these patients. +other 33490119 hsa-mir-29b Univentricular Heart Results: According to microarray analysis, 50 miRNAs were found to be significantly abundant in UVH patients of which miR-29b-3p and miR-29c-3p were significantly related to the model of end-stage liver disease (MELD)-Albumin and albumin-bilirubin (ALBI) score representing advanced liver fibrosis/cirrhosis. Conclusions: In UVH patients with and without Fontan palliation, miR-29b-3p and miR-29c-3p seem to be markers of advanced liver fibrosis/cirrhosis and thus may be used in the risk assessment of these patients. +other 33490119 hsa-mir-29c Univentricular Heart Results: According to microarray analysis, 50 miRNAs were found to be significantly abundant in UVH patients of which miR-29b-3p and miR-29c-3p were significantly related to the model of end-stage liver disease (MELD)-Albumin and albumin-bilirubin (ALBI) score representing advanced liver fibrosis/cirrhosis. Conclusions: In UVH patients with and without Fontan palliation, miR-29b-3p and miR-29c-3p seem to be markers of advanced liver fibrosis/cirrhosis and thus may be used in the risk assessment of these patients. +other 33490119 hsa-mir-29b Liver Cirrhosis Results: According to microarray analysis, 50 miRNAs were found to be significantly abundant in UVH patients of which miR-29b-3p and miR-29c-3p were significantly related to the model of end-stage liver disease (MELD)-Albumin and albumin-bilirubin (ALBI) score representing advanced liver fibrosis/cirrhosis. Conclusions: In UVH patients with and without Fontan palliation, miR-29b-3p and miR-29c-3p seem to be markers of advanced liver fibrosis/cirrhosis and thus may be used in the risk assessment of these patients. +lncRNA target 33490086 hsa-mir-647 Prostatic Neoplasms CONCLUSION: CircNOLC1, elevated by transcription factor NF-kappaB, promotes PCa progression via a miR-647/PAQR4 axis, and circNOLC1 is a potential biomarker and target for PCa treatment. +exosome 33490068 hsa-mir-20b Prostatic Neoplasms RT-qPCR was used to confirm the differential expressions of six exosomal miRNAs, miR +exosome 33490068 hsa-mir-150 Prostatic Neoplasms RT-qPCR was used to confirm the differential expressions of six exosomal miRNAs, miR +circulation_biomarker_diagnosis_ns 33490068 hsa-mir-423 Prostatic Neoplasms Therefore, our findings demonstrate that a number of plasma exosomal miRNAs are associated with CRPC and miR +exosome 33490068 hsa-mir-320d Prostatic Neoplasms RT-qPCR was used to confirm the differential expressions of six exosomal miRNAs, miR +exosome 33490068 hsa-mir-20a Prostatic Neoplasms RT-qPCR was used to confirm the differential expressions of six exosomal miRNAs, miR +genetics_overexpression_promote 33489916 hsa-mir-942 Carcinoma, Hepatocellular Additionally, we proved overexpression of miR +target gene 33489905 hsa-mir-146b Thyroid Neoplasms Long Non-Coding RNA MAPK8IP1P2 Inhibits Lymphatic Metastasis of Thyroid Cancer by Activating Hippo Signaling via Sponging miR-146b-3p. +other 33489896 hsa-mir-21 Stomach Neoplasms The RNA-Binding Protein DDX18 Promotes Gastric Cancer by Affecting the Maturation of MicroRNA-21. +target gene 33489878 hsa-mir-146b Thyroid Neoplasms Downregulation of miR-146b-3p Inhibits Proliferation and Migration and Modulates the Expression and Location of Sodium/Iodide Symporter in Dedifferentiated Thyroid Cancer by Potentially Targeting MUC20. +target gene 33489803 hsa-mir-138 Adenocarcinoma of Lung Hsa_circ_0006571 promotes spinal metastasis through sponging microRNA-138 to regulate sirtuin 1 expression in lung adenocarcinoma. +target gene 33488865 hsa-mir-101 Ovarian Neoplasms MicroRNA-101 inhibits growth and metastasis of human ovarian cancer cells by targeting PI3K/AKT. +target gene 33488801 hsa-mir-615 Breast Neoplasms MicroRNA-615-5p regulates the proliferation and apoptosis of breast cancer cells by targeting HSF1. +genetics_knock down_promote 33488124 hsa-mir-140 Carcinoma, Hepatocellular miR-140 down-regulation or HK2 up-regulation mitigated the influence of NR2F1-AS1 silence on hypoxia-induced glycolysis and migration in HCC cells. CONCLUSION: NR2F1-AS1 knockdown restrained hypoxia-induced glycolysis and migration in HCC cells via increasing miR-140 and decreasing HK2. +lncRNA target 33488123 hsa-mir-20a Nasopharyngeal Carcinoma CONCLUSION: Collectively, these results reveal the presence of a novel TMPO-AS1/miR-320a/SOX4 pathway associated with NPC progression, suggesting that lncRNA TMPO-AS1 may be a potential therapeutic target for NPC. +genetics_knock down_promote 33488122 hsa-mir-491 Breast Neoplasms 5p markedly suppressed BC cell migration and invasion, and knockdown of miR +transcription factor target 33488104 hsa-mir-129 Nerve Degeneration 3p suppressed glucose fluctuation-mediated neuronal damage by targeting MCU via a mitochondrial-dependent intrinsic apoptotic pathway. +exosome 33488100 hsa-mir-1252 Multiple Myeloma MicroRNA-1252-5p Associated with Extracellular Vesicles Enhances Bortezomib Sensitivity in Multiple Myeloma Cells by Targeting Heparanase. +genetics_overexpression_promote 33487072 hsa-mir-30 Ovarian Neoplasms Overexpression of miR +exosome 33486986 hsa-mir-26a Albuminuria In particular miR-26a, major regulator of TGF-beta signaling, was found downregulated in both type of exosomes when compared with healthy controls and to hypertension normoalbuminurics (P<0.01). +exosome 33486986 hsa-mir-26a Hypertension In particular miR-26a, major regulator of TGF-beta signaling, was found downregulated in both type of exosomes when compared with healthy controls and to hypertension normoalbuminurics (P<0.01). +lncRNA target 33486611 hsa-mir-148a Thyroid Carcinoma, Anaplastic CONCLUSION: UCA1 attenuated the killing effect of cytotoxic CD8 T cells on ATC cells through the miR-148a/PD-L1 pathway. +lncRNA target 33486545 hsa-mir-155 Intervertebral Disc Degeneration 3p or silenced KDM3A promotes the proliferation, autophagy, and restrains the apoptosis of NP cells of IDD via inhibition of HIF1alpha, which may be a promising approach for the treatment of IDD. +genetics_overexpression_promote 33485374 hsa-mir-876 Carcinoma, Hepatocellular By conducting rescue experiments, we found the overexpression of SSR2 or knocking down the level of miR +other 33485372 hsa-mir-433 Polycystic Ovary Syndrome 5p to promote PIK3CD expression, thereby regulating the growth and apoptosis of granulose cells in PCOS. +other 33485366 hsa-mir-517a Obesity By clinical and bioinformatics analysis, LEP may be also regulated by miR-517a/b expression in AML. +other 33485366 hsa-mir-517b Obesity By clinical and bioinformatics analysis, LEP may be also regulated by miR-517a/b expression in AML. +other 33485366 hsa-mir-517b Leukemia, Myeloid, Acute By clinical and bioinformatics analysis, LEP may be also regulated by miR-517a/b expression in AML. +other 33485366 hsa-mir-517a Leukemia, Myeloid, Acute By clinical and bioinformatics analysis, LEP may be also regulated by miR-517a/b expression in AML. +genetics_overexpression_suppress 33485295 hsa-mir-129 Neonatal Sepsis Overexpression of miR +circRNA target 33484498 hsa-mir-1294 Carcinoma, Hepatocellular CircCAMSAP1 was up-regulated in HCC tissues, and circCAMSAP1 up-regulated GRAMD1A expression to promote HCC proliferation, migration and invasion through miR-1294. +genetics_GWAS 33484447 hsa-mir-145 Renal Insufficiency, Chronic To date, no data regarding the link between miR143/145 cluster polymorphisms and the risk of developing chronic kidney disease (CKD) has been reported. We found that miR-143/145 cluster polymorphisms were associated with CKD risk in a sample of the Iranian population. +genetics_GWAS 33484447 hsa-mir-143 Renal Insufficiency, Chronic To date, no data regarding the link between miR143/145 cluster polymorphisms and the risk of developing chronic kidney disease (CKD) has been reported. We found that miR-143/145 cluster polymorphisms were associated with CKD risk in a sample of the Iranian population. +genetics_GWAS 33483902 hsa-mir-17 Parkinson Disease Our results provide a link bridging environmental insults and epigenetic changes and implicate miR-17 in therapeutical modulation of DNA methylation in PD. +other 33483746 hsa-mir-21 Myocarditis Phase 2: Treatment with antagomiR-21a-5p, formulated in polymeric nanoparticles for systemic injection, significantly attenuated myocardial inflammation (P = 0.001) and fibrosis (P = 0.013), as well as myocardial 'hypertrophy' on TTE. CONCLUSIONS: Silencing of miR-21a-5p results in a significant reduction of the expression of pro-inflammatory cytokines in vitro, as well as a significant attenuation of inflammation, fibrosis and echocardiographic effects of EAM in vivo. +other 33483742 hsa-mir-122 Liver Injury The objective of this study was to evaluate the diagnostic performance of promising biomarkers of liver injury-glutamate dehydrogenase (GLDH), cytokeratin-18 (K18), caspase-cleaved K18 (ccK18), osteopontin (OPN), macrophage colony-stimulating factor (MCSF), MCSF receptor (MCSFR), and microRNA-122 (miR-122) in comparison to the traditional biomarker alanine aminotransferase (ALT). K18 mRNA (Krt18) and MiR-122 were highly expressed in liver whereas GLDH mRNA (Glud1) was widely expressed. +other 33483741 hsa-mir-29 Cardiovascular Diseases METHODS AND RESULTS: Hyperglycaemia induces increased nuclear factor-kappaB (NF-kappaB) signalling, up-regulation of miR-27a-3p, down-regulation of nuclear factor erythroid-2 related factor 2 (NRF2) expression, increased transforming growth factor-beta (TGF-beta) signalling, down-regulation of miR-29, and induction of endothelial-to-mesenchymal transition (EndMT), all of which are memorized by ECs and not erased when switched to a low glucose condition, thereby causing perivascular fibrosis and cardiac dysfunction. +other 33483741 hsa-mir-29 Diabetes Mellitus METHODS AND RESULTS: Hyperglycaemia induces increased nuclear factor-kappaB (NF-kappaB) signalling, up-regulation of miR-27a-3p, down-regulation of nuclear factor erythroid-2 related factor 2 (NRF2) expression, increased transforming growth factor-beta (TGF-beta) signalling, down-regulation of miR-29, and induction of endothelial-to-mesenchymal transition (EndMT), all of which are memorized by ECs and not erased when switched to a low glucose condition, thereby causing perivascular fibrosis and cardiac dysfunction. +lncRNA target 33482824 hsa-mir-130a Carcinoma, Renal Cell CONCLUSIONS CCAT1/miR-130a-3p axis may have potential to serve as a novel diagnostic and prognostic target of ccRCC patients. +lncRNA target 33482821 hsa-mir-335 Stomach Neoplasms 5p and the cell cycle-related target gene MAPK10 in GC were correlated, and MAPK10 was directly targeted by miR +target gene 33482820 hsa-mir-211 Urinary Bladder Neoplasms Silenced lncRNA SNHG14 restrains the biological behaviors of bladder cancer cells via regulating microRNA-211-3p/ESM1 axis. +target gene 33482814 hsa-mir-124 Stomach Neoplasms Hydrogen inhibits the proliferation and migration of gastric cancer cells by modulating lncRNA MALAT1/miR-124-3p/EZH2 axis. +other 33482192 hsa-mir-155 Osteoarthritis Besides, the level of Vaspin was reduced and the miroRNA155 (miR155) expression was increased in OA knee cartilage of rats. +other 33482190 hsa-mir-155 Fibrous Dysplasia, Polyostotic Considering the critical role of NHLF activation in PF pathogenesis, the NF-kappaB/MIR155HG/miR-627/HMGB1 regulatory loop could exert a vital effect on PF pathogenesis. +lncRNA target 33482190 hsa-mir-627 Fibrous Dysplasia, Polyostotic In the present study, we investigated the upstream factors leading to miR-627 dysregulation in the process of pulmonary fibroblast activation and PF. Considering the critical role of NHLF activation in PF pathogenesis, the NF-kappaB/MIR155HG/miR-627/HMGB1 regulatory loop could exert a vital effect on PF pathogenesis. +other 33482190 hsa-mir-627 Pulmonary Fibrosis In our previous study, we confirmed that the miR-627/high-mobility group box protein 1 (HMGB1)/Nuclear factor kappa beta (NF-kappaB) axis modulates transforming growth factor beta 1 (TGFbeta1)-induced pulmonary fibrosis. +other 33482190 hsa-mir-155 Pulmonary Fibrosis The lncRNA MIR155 host gene (MIR155HG) was found to be abnormally upregulated in pulmonary fibrosis tissues and TGFbeta1-stimulated normal human primary lung fibroblasts (NHLFs). +other 33482178 hsa-mir-874 Intervertebral Disc Degeneration The miR3p/MMP2/MMP3 axis might also provide direction for future cancer and inflammation investigations. +transcription factor target 33481985 hsa-mir-665 Dysautonomia, Familial 3p expression in FK upregulated autophagy and alleviated inflammation. +other 33481955 hsa-mir-155 Aortic Valve Insufficiency Previous results from our group and others have shown that urinary pellet expression of miR155-5p and urinary CXCL-10 production could play a key role in the prognosis and diagnosis of acute rejection (AR) in kidney transplantation patients. Here, a logistic regression model was developed using NONMEM to quantify the relationships of miR155-5p urinary expression, CXCL-10 urinary concentration and tacrolimus and mycophenolic acid (MPA) exposure with the probability of AR in adult kidney transplant patients during the early post-transplant period. +other 33481955 hsa-mir-155 Primary Graft Dysfunction Previous results from our group and others have shown that urinary pellet expression of miR155-5p and urinary CXCL-10 production could play a key role in the prognosis and diagnosis of acute rejection (AR) in kidney transplantation patients. +genetics_overexpression_promote 33481659 hsa-mir-429 Wilms Tumor induced influences in Wilms' tumor cells were largely counteracted by the overexpression of FRS2. +genetics_knock down_promote 33481351 hsa-mir-660 Carcinoma, Hepatocellular Subsequently, rescue assays were conducted and it was indicated that loss of BAG5 reversed the effects of miR-660 inhibitors on HCC partially. +transcription factor target 33481338 hsa-mir-223 Uterine Cervical Neoplasms miR-223 targeted the 3'-UTR of thioredoxin interacting protein (TXNIP) and suppressed its expression, leading to increased CC development in vitro and in vivo. +genetics_overexpression_promote 33481334 hsa-mir-223 Uterine Cervical Neoplasms miR-223, upregulated in CC, was regulated by HDAC10 through histone acetylation, while miR-223 inhibited the effects of HDAC10 overexpression in CC. miR-223 targeted the 3'-UTR of thioredoxin interacting protein (TXNIP) and suppressed its expression, leading to increased CC development in vitro and in vivo. +other 33481268 hsa-mir-155 Alzheimer Disease In conclusion, downregulation of TNF-alpha, miR-155, and pAkt and increased SHIP-1 could improve the neuro-inflammatory state and cognitive function of LPS-induced Alzheimer's disease. +genetics_knock down_promote 33481227 hsa-mir-21 Thyroid Cancer, Papillary CONCLUSION: These findings suggested that circPUM1 knockdown inhibited MAPK1 expression by targeting miR +lncRNA target 33481135 hsa-mir-654 Acute Kidney Injury In conclusion, our results demonstrate that LINC00261 may regulate the progression of sepsis-induced acute kidney injury via the miR5p/SOCS3/NF-kappaB pathway and therefore provides a new insight into the treatment of this disease. +lncRNA target 33481135 hsa-mir-654 Sepsis In conclusion, our results demonstrate that LINC00261 may regulate the progression of sepsis-induced acute kidney injury via the miR5p/SOCS3/NF-kappaB pathway and therefore provides a new insight into the treatment of this disease. +other 33481014 hsa-mir-185 Colorectal Neoplasms 5p/HMGA2 axis participated in the progression of CRC. +genetics_knock down_suppress 33481008 hsa-mir-361 Triple Negative Breast Neoplasms It has been proven that circGFRA1 knockdown can inhibit the resistance of TNBC cells to PTX by promoting the expression of miR +lncRNA target 33480984 hsa-mir-374b Breast Neoplasms By using bioinformatics tools, we predicted that miR-374b plays a role in breast cancer cells through negatively regulating cyclin D1 (CCND1) and transforming growth factor alpha (TGFA). +other 33480702 hsa-mir-21 Adenocarcinoma of Lung The purpose of this study was to construct a novel antisense nanoprobe, (99m)Tc-labeled anti-miRNA oligonucleotides/cell-penetrating peptide PepFect6 ((99m)Tc-AMO/PF6), and to evaluate its efficacy for imaging the miRNA-21 expression in A549 lung adenocarcinoma xenografts. +transcription factor target 33480329 hsa-mir-155 Alzheimer Disease MiR-155 plays main roles in several physiological and pathological mechanisms, such as Down syndrome (DS), immunity and inflammation and potential anti-AD therapeutic target. +transcription factor target 33480329 hsa-mir-155 Down Syndrome MiR-155 plays main roles in several physiological and pathological mechanisms, such as Down syndrome (DS), immunity and inflammation and potential anti-AD therapeutic target. +lncRNA target 33480300 hsa-mir-92a Intracranial Aneurysm CONCLUSION: HDAC9 inhibition upregulates miR-92a to repress the progression of IA via silencing BCL2L11. +lncRNA target 33480288 hsa-mir-203a Carcinoma, Hepatocellular The present study demonstrated that (D)TBP-3NP-siANRIL exhibited an excellent anti-tumour effect on hepatoma carcinoma in vivo by simultaneously inhibited the expression of miR-203a and its downstream genes and increased the percentages of NK cells and T cells. +genetics_overexpression_promote 33479848 hsa-mir-506 Nasopharyngeal Carcinoma Interestingly, overexpression of LINC01433 promoted proliferation, migration and invasion of NPC cells, while miR +lncRNA target 33479730 hsa-mir-921 Breast Neoplasms Then, we demonstrated that circNINL could interact with miR-921 and facilitate BC cells malignant process including proliferation acceleration, migration enhancement and apoptosis evasion via sponging miR-921 in vitro. +genetics_knock down_promote 33479458 hsa-mir-224 Osteosarcoma 3p or overexpression of Rab10, thereby confirming the in vitro role of EBLN3P in promoting osteosarcoma cell proliferation, migration and invasion. +lncRNA target 33479208 hsa-mir-296 Thyroid Cancer, Papillary 3p and the tumor-promoting effect of DDHD2 were further investigated in PTC, indicating that circRUNX1 modulates PTC progression through the miR +exosome 33479185 hsa-mir-146a Ischemic Stroke We conclude that miR-146a-5p derived from hUMSC-Exos can attenuate microglia-mediated neuroinflammation and consequent neural deficits following ischemic stroke. +exosome 33479185 hsa-mir-146a Nerve Degeneration We conclude that miR-146a-5p derived from hUMSC-Exos can attenuate microglia-mediated neuroinflammation and consequent neural deficits following ischemic stroke. +exosome 33479185 hsa-mir-146a Neurogenic Inflammation We conclude that miR-146a-5p derived from hUMSC-Exos can attenuate microglia-mediated neuroinflammation and consequent neural deficits following ischemic stroke. +lncRNA target 33478874 hsa-mir-370 Stomach Neoplasms Further analysis indicated that CASC9 directly targeted miR-370 and negatively regulated miR-370 expression in GC. Taken together our results support a model in which CASC9 promotes GC progression through miR-370/EGFR/ERK/AKT pathway. +transcription factor target 33477683 hsa-mir-424 Breast Neoplasms As expected, miR5p suppressed proliferation and stimulated apoptosis of the MCF-7 cells. +other 33477489 hsa-mir-210 Inflammation MicroRNA (miR)-210 is associated with cellular adaptation to cellular stress and inflammation. +lncRNA target 33477144 hsa-mir-96 Rhinitis, Allergic 5p might be used as a diagnostic marker and therapeutic target for the treatment of AR. +genetics_overexpression_promote 33476715 hsa-mir-874 Cholangiocarcinoma Therefore, the overexpression of miR-874 might bring favorable outcomes for the treatment of CC. +transcription factor target 33476677 hsa-mir-19a Myocardial Reperfusion Injury In conclusion, metformin can alleviate H/R-induced cells injury via regulating miR-19a/ACSL axis, which lays a foundation for identifying novel targets for myocardial I/R injury therapy. +transcription factor target 33476668 hsa-mir-181b Edwardsiella tarda In addition, the 43 negatively correlated miRNA-mRNA pairs were identified using integrated miRNA-mRNA analysis, which including immune-related miRNAs and target genes such as miR-144, miR-1260, miR-1388, miR-33, miR-338, miR-181b, miR-34c, miR-135 and CLEC4E, LITR, PIKfyve, NCF4, IL-12beta, IP6K2, TNFRSF9, IL-4Ralpha, IRF2, Mx2. +transcription factor target 33476668 hsa-mir-34c Edwardsiella tarda In addition, the 43 negatively correlated miRNA-mRNA pairs were identified using integrated miRNA-mRNA analysis, which including immune-related miRNAs and target genes such as miR-144, miR-1260, miR-1388, miR-33, miR-338, miR-181b, miR-34c, miR-135 and CLEC4E, LITR, PIKfyve, NCF4, IL-12beta, IP6K2, TNFRSF9, IL-4Ralpha, IRF2, Mx2. +transcription factor target 33476668 hsa-mir-338 Edwardsiella tarda In addition, the 43 negatively correlated miRNA-mRNA pairs were identified using integrated miRNA-mRNA analysis, which including immune-related miRNAs and target genes such as miR-144, miR-1260, miR-1388, miR-33, miR-338, miR-181b, miR-34c, miR-135 and CLEC4E, LITR, PIKfyve, NCF4, IL-12beta, IP6K2, TNFRSF9, IL-4Ralpha, IRF2, Mx2. +transcription factor target 33476668 hsa-mir-1388 Edwardsiella tarda In addition, the 43 negatively correlated miRNA-mRNA pairs were identified using integrated miRNA-mRNA analysis, which including immune-related miRNAs and target genes such as miR-144, miR-1260, miR-1388, miR-33, miR-338, miR-181b, miR-34c, miR-135 and CLEC4E, LITR, PIKfyve, NCF4, IL-12beta, IP6K2, TNFRSF9, IL-4Ralpha, IRF2, Mx2. +transcription factor target 33476668 hsa-mir-1260 Edwardsiella tarda In addition, the 43 negatively correlated miRNA-mRNA pairs were identified using integrated miRNA-mRNA analysis, which including immune-related miRNAs and target genes such as miR-144, miR-1260, miR-1388, miR-33, miR-338, miR-181b, miR-34c, miR-135 and CLEC4E, LITR, PIKfyve, NCF4, IL-12beta, IP6K2, TNFRSF9, IL-4Ralpha, IRF2, Mx2. +transcription factor target 33476668 hsa-mir-3 Edwardsiella tarda In addition, the 43 negatively correlated miRNA-mRNA pairs were identified using integrated miRNA-mRNA analysis, which including immune-related miRNAs and target genes such as miR-144, miR-1260, miR-1388, miR-33, miR-338, miR-181b, miR-34c, miR-135 and CLEC4E, LITR, PIKfyve, NCF4, IL-12beta, IP6K2, TNFRSF9, IL-4Ralpha, IRF2, Mx2. +transcription factor target 33476668 hsa-mir-144 Edwardsiella tarda In addition, the 43 negatively correlated miRNA-mRNA pairs were identified using integrated miRNA-mRNA analysis, which including immune-related miRNAs and target genes such as miR-144, miR-1260, miR-1388, miR-33, miR-338, miR-181b, miR-34c, miR-135 and CLEC4E, LITR, PIKfyve, NCF4, IL-12beta, IP6K2, TNFRSF9, IL-4Ralpha, IRF2, Mx2. +circulation_biomarker_diagnosis_up 33476198 hsa-mir-7-1 Diabetes Mellitus, Type 2 5p and miR-33a-5p in plasma of three groups including pre-diabetic patients (n=20), T2D patients (n=20) and control group (n=20), using RT-qPCR. +circulation_biomarker_diagnosis_up 33476198 hsa-mir-33a Diabetes Mellitus, Type 2 5p and miR-33a-5p in plasma of three groups including pre-diabetic patients (n=20), T2D patients (n=20) and control group (n=20), using RT-qPCR. +circulation_biomarker_diagnosis_up 33476198 hsa-mir-7 Diabetes Mellitus, Type 2 5p and miR-33a-5p in plasma of three groups including pre-diabetic patients (n=20), T2D patients (n=20) and control group (n=20), using RT-qPCR. +other 33475963 hsa-mir-155 Breast Neoplasms CONCLUSIONS: We demonstrated that miR-155 has great potential to facilitate accurate BC detection and may serve as a promising diagnostic biomarker for BC. +transcription factor target 33475463 hsa-mir-125a Myocardial Reperfusion Injury In conclusion, our results demonstrated that sufentanil pretreatment produced a protective effect against myocardial IRI via regulating miR-125a/DRAM2 signaling axis. +lncRNA target 33475455 hsa-mir-362 Retinoblastoma 3p targets USP22 and then restrains invasion, proliferation and migration while promotes apoptosis of RB via reducing LSD1 modified by deubiquitination. +genetics_knock down_promote 33475233 hsa-mir-626 Lung Neoplasms LIFR was targeted via miR-626, and miR-626 knockdown constrained cell viability and invasion and facilitated apoptosis in lung cancer cells via up-regulating LIFR. +circulation_biomarker_diagnosis_ns 33474702 hsa-mir-101a Instent Restenosis Diagnostic utility of circulating plasma microRNA-101a in severity of coronary heart disease. +genetics_overexpression_promote 33474692 hsa-mir-4319 Retinoblastoma In summary, miR-4319 overexpression suppressed cell proliferation, migration and invasion may through suppressing the CD147 mediated MMPs expression, suggesting that miR-4319 may serve as a potential diagnostic biomarker and treatment target for RB. +other 33473354 hsa-mir-20a Myocarditis In FM patients, hsa-miR-30a, hsa-miR-192, hsa-miR-146a, hsa-miR-155, and hsa-miR-320a were validated as significantly and differentially expressed candidates that could serve as potential markers for diagnosing FM. In addition, the miRNA panel (hsa-miR-155 and hsa-miR-320a) from the multivariate logistic regression model demonstrated high accuracy in the diagnosis of FM and was able to distinguish FM from HCs and NFM. +other 33473354 hsa-mir-155 Myocarditis In FM patients, hsa-miR-30a, hsa-miR-192, hsa-miR-146a, hsa-miR-155, and hsa-miR-320a were validated as significantly and differentially expressed candidates that could serve as potential markers for diagnosing FM. In addition, the miRNA panel (hsa-miR-155 and hsa-miR-320a) from the multivariate logistic regression model demonstrated high accuracy in the diagnosis of FM and was able to distinguish FM from HCs and NFM. +other 33473330 hsa-mir-93 Wound Healing The miR-93-3p/ZFP36L1/ZFX axis regulates keratinocyte proliferation and migration during skin wound healing. +other 33473256 hsa-mir-708 Carcinoma, Non-Small-Cell Lung miR-708-5p enhances erlotinib/paclitaxel efficacy and overcomes chemoresistance in lung cancer cells. +transcription factor target 33473254 hsa-mir-4287 Prostatic Neoplasms Since miR-4287 specifically targets metastasis pathway mediators, miR-4287 has potential diagnostic and therapeutic significance in preventing advanced, metastatic disease. +genetics_knock down_suppress 33473055 hsa-mir-154 Thyroid Cancer, Papillary Our findings identified that the knockdown of circ_0008274 repressed PTC malignant progression at least in part through regulating the miR +genetics_knock down_promote 33472945 hsa-mir-135a Diabetic Nephropathies Mechanistically, we identified that a loss of circRNA_010383 promoted proteinuria and renal fibrosis in DN by acting as a sponge for miR-135a. +genetics_knock down_promote 33472945 hsa-mir-135a Fibrosis, Renal Mechanistically, we identified that a loss of circRNA_010383 promoted proteinuria and renal fibrosis in DN by acting as a sponge for miR-135a. +other 33472665 hsa-mir-744 Carcinoma, Non-Small-Cell Lung CONCLUSION: Overall, our findings unveiled a mechanism whereby miR-744 delivered by NSCLC-derived EVs upregulated SUV39H1, activating the Smad9/BMP9 axis and thus promoted cancer development. +genetics_GWAS 33472642 hsa-mir-128 Bone Neoplasms Genetic knockdown of miR-128 in bone neoplasms cells suppressed the activation of the Wnt/beta-catenin and epithelial-mesenchymal transition (EMT) signaling pathways. +genetics_overexpression_promote 33472614 hsa-mir-636 Ovarian Neoplasms Besides, overexpressing Gli2 potentiated the EMT process of OVC cells via decreasing E-cadherin protein expression and increasing Vimentin protein expression, and it reversed the inhibitory effect of miR-636 on OVC cell proliferation in vivo. +genetics_overexpression_promote 33472586 hsa-mir-527 Stomach Neoplasms Mechanism diagram: During GC development, overexpressed circ_0005529 sponged miR-527 and then upregulated the expression of Sp1. +genetics_overexpression_promote 33472555 hsa-mir-149 Colorectal Neoplasms Finally, overexpression of LINC00460 upregulated the expression levels of biglycan, a target gene of miR +genetics_overexpression_promote 33472512 hsa-mir-340 Carcinoma, Renal Cell Overexpression of miR +lncRNA target 33472456 hsa-mir-363 Breast Neoplasms Downregulation of miR-363 or upregulation of SERTAD3 stimulated TAM resistance of BC cells. It could be concluded that silencing HNF1A-AS1 inhibited growth and drug resistance to TAM of BC cells through the miR-363/SERTAD3 axis and the inactivation of the TGF-beta/Smad pathway. +lncRNA target 33472424 hsa-mir-200c Hemangioma These findings indicate that miR-200c-3p targets the Notch signaling pathway to promote the proliferation of vascular endothelial cells, suggesting that miR-200c-3p plays an important role in the pathogenesis of hemangioma. +other 33472424 hsa-mir-200c Hemangioma, Cavernous The microRNA miR-200c-3p is abnormally expressed in some types of tumors, but its expression, biological role, and mechanism of action in infantile hemangioma remain to be fully elucidated. +genetics_overexpression_promote 33472323 hsa-mir-758 Carcinoma, Non-Small-Cell Lung 3p mimics and NUSAP1-overexpression vector indicated as miR +genetics_overexpression_promote 33472170 hsa-mir-155 Triple Negative Breast Neoplasms 5p enhanced the anti-tumor effect of cetuximab in an MDA-MB-468 xenograft model and on EGFR-overexpressed TNBC cells via inducing cell apoptosis and pyroptosis. +other 33471295 hsa-mir-124 Alzheimer Disease Syringin ameliorated Abeta(25-35)-induced neurotoxicity in SK-N-SH and SK-N-BE cells by regulating miR3p/BID pathway, which could be a novel theoretical basis for syringin to treat AD. +genetics_knock down_promote 33470895 hsa-mir-4319 Leukemia, Myeloid, Acute Circ_0058058 knockdown inhibited cell proliferation, migration, and invasion, but accelerated cell apoptosis by reducing EIF5A2 expression by targeting miR-4319, suggesting that circ_0058058 could be a therapeutic target for the treatment of AML. +circRNA target 33470617 hsa-mir-485 Esophageal Squamous Cell Carcinoma Circ_0000554 silencing repressed EC progression and enhanced cell radiosensitivity through downregulating FERMT1 via sponging miR +genetics_knock down_suppress 33470616 hsa-mir-383 Prostatic Neoplasms 5p could partially restore the effects of SNHG1 knockdown on prostate cancer cell proliferation, apoptosis, migration and invasion. +genetics_knock down_promote 33470475 hsa-mir-370 Endometriosis 3p overexpression or knockdown in ectopic endometrial hEM15A cells, the changes in the proliferation, apoptosis, and migration and invasion capacities were detected by using cell counting kit-8, flow cytometry, and transwell methods. +genetics_overexpression_suppress 33470443 hsa-mir-196a Hepatitis C Overexpression of miR-196a in Huh 7.5 replicon cell is a potential new strategy to prevent hepatitis C infection. +other 33470394 hsa-mir-369 Heart Injuries However, the role of miR-369 in regulating hypoxia-induced heart injury remains unknown. +other 33470394 hsa-mir-369 Myocardial Infarction Our data indicated that miR-369 expression was significantly down-regulated and TRPV3 was significantly up-regulated in myocardial tissue after MI in rats and in hypoxic-treated neonatal rat cardiomyocytes (NRCMs). +other 33470394 hsa-mir-369 Cardiomyopathies miR-369 has been suggested to be a key regulator of cardiac fibrosis. +genetics_overexpression_promote 33470394 hsa-mir-369 Hypoxia miR-369 overexpression significantly suppressed cell apoptosis and inflammatory factor production triggered by hypoxia, whereas miR-369 inhibition had an opposite effect. +other 33469902 hsa-mir-126 Acute Coronary Syndrome CONCLUSION: Platelet-related miR-21 and miR-126 are associated with MPA formation in ACS patients on DAPT. +other 33469902 hsa-mir-21 Acute Coronary Syndrome CONCLUSION: Platelet-related miR-21 and miR-126 are associated with MPA formation in ACS patients on DAPT. +genetics_overexpression_promote 33469841 hsa-mir-196a Glioblastoma miR-196a overexpression was found to induce cellular proliferation, migration, spheroid formation and colony formation and to inhibit apoptosis, while miR-196a inhibition using anti-miR-196a yielded opposite results, suggesting an oncogenic role of miR-196a in GBM. +lncRNA target 33469676 hsa-mir-153 Liver Neoplasms Furthermore, circ_0008537 indirectly affected the expression levels of prosurvival protein myeloid cell leukemia 1 (MCL1) and snail family zinc finger 1 (Snail1) via miR1533p in liver cancer cells. +other 33469418 hsa-mir-130a Arnold-Chiari Malformation 3p (upregulated in ACTS vs. NCs); miR-451a (upregulated in AC vs. TS and NCs; in ACTS vs. NCs). +other 33469418 hsa-mir-222 Arnold-Chiari Malformation 3p (upregulated in ACTS vs. NCs); miR-451a (upregulated in AC vs. TS and NCs; in ACTS vs. NCs). +other 33469418 hsa-mir-23a Arnold-Chiari Malformation 3p (upregulated in ACTS vs. NCs); miR-451a (upregulated in AC vs. TS and NCs; in ACTS vs. NCs). +other 33469418 hsa-mir-93 Arnold-Chiari Malformation 3p (upregulated in ACTS vs. NCs); miR-451a (upregulated in AC vs. TS and NCs; in ACTS vs. NCs). +other 33469418 hsa-let-7b Arnold-Chiari Malformation 3p (upregulated in ACTS vs. NCs); miR-451a (upregulated in AC vs. TS and NCs; in ACTS vs. NCs). +other 33469418 hsa-mir-25 Arnold-Chiari Malformation 3p (upregulated in ACTS vs. NCs); miR-451a (upregulated in AC vs. TS and NCs; in ACTS vs. NCs). +other 33469418 hsa-mir-21 Arnold-Chiari Malformation 3p (upregulated in ACTS vs. NCs); miR-451a (upregulated in AC vs. TS and NCs; in ACTS vs. NCs). +other 33469418 hsa-mir-144 Arnold-Chiari Malformation 3p (upregulated in ACTS vs. NCs); miR-451a (upregulated in AC vs. TS and NCs; in ACTS vs. NCs). +other 33469418 hsa-mir-451a Arnold-Chiari Malformation 3p (upregulated in ACTS vs. NCs); miR-451a (upregulated in AC vs. TS and NCs; in ACTS vs. NCs). +target gene 33469378 hsa-mir-513a Stomach Neoplasms LncRNA UCA1 Enhances Cisplatin Resistance by Regulating CYP1B1-mediated Apoptosis via miR-513a-3p in Human Gastric Cancer. +target gene 33469368 hsa-mir-557 Pancreatic Neoplasms Up-Regulation of circEIF6 Contributes to Pancreatic Cancer Development Through Targeting miR-557/SLC7A11/PI3K/AKT Signaling. +target gene 33469358 hsa-mir-1298 Breast Neoplasms miR-1298-5p Influences the Malignancy Phenotypes of Breast Cancer Cells by Inhibiting CXCL11. +lncRNA target 33469348 hsa-mir-376c Carcinoma, Hepatocellular HCC cells were treated with miR-19a-3p inhibitor, miR-376c-3p inhibitor, or oe-SOX-6 to figure out their functions in HCC malignancy. +lncRNA target 33469348 hsa-mir-19a Carcinoma, Hepatocellular HCC cells were treated with miR-19a-3p inhibitor, miR-376c-3p inhibitor, or oe-SOX-6 to figure out their functions in HCC malignancy. +lncRNA target 33469315 hsa-mir-484 Carcinoma, Renal Cell MiR-484 counteracted the functions of PCED1B-AS1 in promoting the proliferation, migration and EMT of ccRCC cells, and PCED1B-AS1 promotes the expression of ZEB1 via repressing miR-484. +lncRNA target 33469313 hsa-mir-326 Colorectal Neoplasms CONCLUSION: Taken together, the data showed that EWSAT1 promoted CRC progression via targeting miR-326/FBXL20 pathway, which might provide a novel therapeutic target for CRC treatment. +other 33469312 hsa-mir-4262 Uterine Cervical Neoplasms CRNDE Contributes Cervical Cancer Progression by Regulating miR-4262/ZEB1 Axis. +target gene 33469309 hsa-mir-21 Ovarian Neoplasms miR-21 Induces Chemoresistance in Ovarian Cancer Cells via Mediating the Expression and Interaction of CD44v6 and P-gp. +genetics_overexpression_promote 33469291 hsa-mir-20b Diabetes Mellitus RESULTS: We determined that miR-20b-5p was overexpressed in Dia-Exos and that it functioned by impairing wound repair by suppressing vascular endothelial growth factor A (VEGFA) expression. CONCLUSION: Dia-Exos exhibit significant increases in miR-20b-5p relative to Con-Exos, and this miRNA can be transferred into HSFs wherein it can suppress VEGFA expression and thereby slow the process of wound healing. +lncRNA target 33469278 hsa-mir-197 Osteoporosis 3p inhibitor and si-klf10, ALP, Runx2, OCN and OSX mRNA, cell survival rate and mineralized nodule were significantly decreased in primary osteoblasts and MC3T3-E1 cells. +other 33468167 hsa-mir-7 Osteoarthritis 5p, MDM2, GSK3B, TMED10, DCAF12, CASP3, and RNF44 may play critical roles in OA progression. +other 33468167 hsa-mir-182 Osteoarthritis 5p, MDM2, GSK3B, TMED10, DCAF12, CASP3, and RNF44 may play critical roles in OA progression. +other 33468167 hsa-mir-98 Osteoarthritis 5p, MDM2, GSK3B, TMED10, DCAF12, CASP3, and RNF44 may play critical roles in OA progression. +exosome 33468159 hsa-mir-27a Colonic Neoplasms Exosomes derived from colon cancer cells repressed IRF4 expression in Tregs by transmitting miR-27a-3p, miR-30a-5p and miR-320c. +exosome 33468159 hsa-mir-320c Colonic Neoplasms Exosomes derived from colon cancer cells repressed IRF4 expression in Tregs by transmitting miR-27a-3p, miR-30a-5p and miR-320c. +lncRNA target 33468140 hsa-mir-127 Carcinoma, Renal Cell 3p and prevents its suppression of a downstream gene, CDKN3, and the E2F1 pathway, thereby leading to RCC malignant progression. +genetics_knock down_promote 33467979 hsa-mir-20b Arthritis, Gouty LncRNA HOTAIR and Nlrp3 expression was upregulated, and that of miR-20b was downregulated in synovial fluid mononuclear cells (SFMCs) collected from patients with gouty arthritis and monosodium urate (MSU)-stimulated THP-1 cells. These findings suggest that lncRNA HOTAIR knockdown suppresses inflammatory cytokine secretion by upregulating miR-20b and downregulating NLRP3, thereby alleviating ankle swelling in gouty arthritis. +lncRNA target 33467964 hsa-mir-21 Carcinoma, Non-Small-Cell Lung Circular RNA circ_0001287 inhibits the proliferation, metastasis, and radiosensitivity of non-small cell lung cancer cells by sponging microRNA miR-21 and up-regulating phosphatase and tensin homolog expression. +other 33467738 hsa-mir-16 Diabetes, Gestational 5p levels were observed in women, who were NGT at baseline and later developed GDM, compared with controls who remained NGT. +transcription factor target 33467725 hsa-mir-424 Triple Negative Breast Neoplasms In conclusion, these results demonstrate that EVs may serve as a delivery system for novel immunotherapies for TNBC through the miR5p/PD-L1 pathway. +genetics_GWAS 33466130 hsa-mir-27a Breast Neoplasms Analysis using five genetic models suggested no significant association between miR-27a rs895819 polymorphism and BC risk in the total population, or specifically in Asian or Chinese subpopulations. +other 33465566 hsa-mir-150 Fibrosis Our data support that miR-150 and miR-495 may contribute to renal fibrogenesis by aggravating the metabolic failure critically involved in tubular epithelial cells, ultimately leading to fibrosis. +other 33465566 hsa-mir-150 Multicystic renal dysplasia, bilateral 5p, respectively, in both the UUO and the folic acid induced nephropathy (FAN) models, while TGF-beta1 upregulated their expressions in the human renal tubular epithelial cell line HKC-8. +other 33465566 hsa-mir-495 Fibrosis Our data support that miR-150 and miR-495 may contribute to renal fibrogenesis by aggravating the metabolic failure critically involved in tubular epithelial cells, ultimately leading to fibrosis. +other 33465566 hsa-mir-495 Folic Acid Deficiency 5p, respectively, in both the UUO and the folic acid induced nephropathy (FAN) models, while TGF-beta1 upregulated their expressions in the human renal tubular epithelial cell line HKC-8. +other 33465566 hsa-mir-150 Folic Acid Deficiency 5p, respectively, in both the UUO and the folic acid induced nephropathy (FAN) models, while TGF-beta1 upregulated their expressions in the human renal tubular epithelial cell line HKC-8. +other 33465566 hsa-mir-495 Multicystic renal dysplasia, bilateral 5p, respectively, in both the UUO and the folic acid induced nephropathy (FAN) models, while TGF-beta1 upregulated their expressions in the human renal tubular epithelial cell line HKC-8. +other 33465419 hsa-mir-663b Colorectal Neoplasms miR-663b is an interesting candidate in CRC pathophysiology. +other 33465368 hsa-mir-103a Hypersensitivity CONCLUSION: Eosinophilic allergic inflammation may be exacerbated owing to ILC2 activation by MC-derived miR103a-3p. +other 33465368 hsa-mir-103a Dermatitis, Atopic Furthermore, the level of miR103a-3p expression was significantly higher in EVs from sera of patients with atopic dermatitis than in EVs from nonatopic healthy control subjects. +other 33465368 hsa-mir-103a Pulmonary Eosinophilia CONCLUSION: Eosinophilic allergic inflammation may be exacerbated owing to ILC2 activation by MC-derived miR103a-3p. +transcription factor target 33465281 hsa-mir-34a Arthritis, Rheumatoid BM-MSC-derived Evs mainly elevated miR-34a expression, which reduced RA inflammation in vivo and inhibited RA-FLS proliferation and resistance to apoptosis in vitro, while inhibited miR-34a expression enhanced RA development. +genetics_overexpression_suppress 33465049 hsa-mir-6784 Carcinoma, Squamous Cell, Skin Functional studies in established (A431 and SCC9) and primary skin SCC cells revealed that miR-6784 overexpression inhibited cell viability, proliferation, migration, and invasion. +lncRNA target 33464650 hsa-mir-25 Hypertension In conclusion, LncRNA SNHG12 alleviates vascular endothelial injury induced by hypertension through miR3p/SIRT6 pathway. +genetics_knock down_suppress 33464477 hsa-mir-1252 Adenocarcinoma of Lung Furthermore, knockdown of LINC00520 inhibited lung ADC cells proliferation, migration and invasion, while co-transfection with a miR +lncRNA target 33464390 hsa-mir-9 Spinal Cord Injuries In conclusion, our data demonstrated that lithium reduced SCI-induced apoptosis and inflammation in rats via the BDNF-AS/miR +genetics_knock down_promote 33464142 hsa-mir-144 Stomach Neoplasms 3p markedly counteracted LINC00265 knockdown-meditated suppression on GC cell proliferation. +transcription factor target 33464097 hsa-mir-124 Thymoma AST-IV improves tibial defects in rats and promotes proliferation and osteogenic differentiation of hBMSCs through the miR3p.1/STAT3 axis. +lncRNA target 33463918 hsa-mir-21 Colorectal Neoplasms In addition, mechanism analysis validated miR-21 as a direct regulator of MEG2, and miR-21 plays a critical role in promoting proliferation, invasion, and suppression of apoptosis in CRC by targeting MEG2. Taken together, this study demonstrates the significant role for miR-21 in regulating MEG2 in CRC and may represent a potential target for CRC therapy. +circulation_biomarker_prognosis_up 33463758 hsa-mir-601 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: Taken together, serum miR-942 and serum miR-601 might serve as a promising molecular signature for the early detection and prognosis prediction of NSCLC. +circulation_biomarker_prognosis_up 33463758 hsa-mir-942 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: Taken together, serum miR-942 and serum miR-601 might serve as a promising molecular signature for the early detection and prognosis prediction of NSCLC. +circulation_biomarker_diagnosis_ns 33463352 hsa-mir-21 Carcinoma, Ovarian Epithelial The purpose of this study was to assess the synergistic effects of two silencing RNAs [salt-inducible kinase 2 (SIK2) siRNA and antisense-microRNA21 (anti-miR21)] encapsulated in long-circulating folate-lipid-poly(lactic-co-glycolic acid) (PLGA) hybrid nanopolymers (FaLPHNPs) administered using an ultrasound- and microbubble (US-MB)-mediated approach to sensitize human EOC xenografts to paclitaxel (PTX). In summary, the results of this study revealed that US-MB-mediated codelivery of SIK2 siRNA, and anti-miR21 encapsulated in a folate-lipid-PLGA hybrid polymer nanoparticle could significantly improve the sensitivity of EOC tumors to PTX and is a highly effective approach for treating EOC in complementary experiments. +genetics_GWAS 33463131 hsa-mir-146a Kidney Diseases The CC genotype, G, and C allele of the miRNA146a G>C and also, the CC genotype, T and C alleles of the miRNA196a-2 C>T may be genetically susceptible factors for transplant rejection and development of kidney disorders, especially in Iranian patients. +genetics_GWAS 33463131 hsa-mir-196a-2 Kidney Diseases The CC genotype, G, and C allele of the miRNA146a G>C and also, the CC genotype, T and C alleles of the miRNA196a-2 C>T may be genetically susceptible factors for transplant rejection and development of kidney disorders, especially in Iranian patients. +genetics_GWAS 33463131 hsa-mir-196a Kidney Diseases The CC genotype, G, and C allele of the miRNA146a G>C and also, the CC genotype, T and C alleles of the miRNA196a-2 C>T may be genetically susceptible factors for transplant rejection and development of kidney disorders, especially in Iranian patients. +transcription factor target 33463130 hsa-mir-34a Prostatic Neoplasms High expression of miR-93 and low expression of miR-34a have previously been indicated in prostate cancer (PC), which is the second leading cause of cancer-related death in men. Our study indicates that the reduced expression of AR and PSA in PC cells followed by treatment with miR-34a mimic and miR-93 inhibitor and their combination with EGCG as a natural substance may be a promising therapeutic way for controlling the growth of these malignant cells. +transcription factor target 33463130 hsa-mir-93 Prostatic Neoplasms High expression of miR-93 and low expression of miR-34a have previously been indicated in prostate cancer (PC), which is the second leading cause of cancer-related death in men. Our study indicates that the reduced expression of AR and PSA in PC cells followed by treatment with miR-34a mimic and miR-93 inhibitor and their combination with EGCG as a natural substance may be a promising therapeutic way for controlling the growth of these malignant cells. +other 33463108 hsa-mir-29b Multiple Sclerosis, Relapsing-Remitting IFN-beta may regulate other miRNAs in Th1 and Th17 cells than miR29b-3p and miR-326 in MS patients. +other 33463108 hsa-mir-326 Multiple Sclerosis, Relapsing-Remitting IFN-beta may regulate other miRNAs in Th1 and Th17 cells than miR29b-3p and miR-326 in MS patients. +other 33463060 hsa-mir-29b Sialic Acid Storage Disease An in vivo SD rat cartilage defect model was carried out to explore the role and mechanism of lncRNA H19/miR-29b-3p. +other 33463060 hsa-mir-29b Cartilage Diseases An in vivo SD rat cartilage defect model was carried out to explore the role and mechanism of lncRNA H19/miR-29b-3p. +other 33463006 hsa-mir-3682 Esophageal Squamous Cell Carcinoma Then, a risk model involving three miRNAs (miR-4521, miR3p, and miR-1269a) was designed to predict prognosis in EC patients. +other 33463006 hsa-mir-4521 Esophageal Squamous Cell Carcinoma Then, a risk model involving three miRNAs (miR-4521, miR3p, and miR-1269a) was designed to predict prognosis in EC patients. +lncRNA target 33462751 hsa-mir-17 Squamous Cell Carcinoma of Head and Neck MiR-17 inhibition enhances cisplatin-induced apoptosis of human tongue squamous carcinoma cell. +circulation_biomarker_diagnosis_ns 33462352 hsa-mir-494 Acute Kidney Injury 3p, a miRNA induced in both circulation of AKI patients and hypoxia-reoxygenation-treated HK2 cells, enhanced renal inflammation by targeting HtrA3, which may suggest a possible role as a new therapeutic target for CSA-AKI. +circulation_biomarker_diagnosis_ns 33462352 hsa-mir-494 Kidney Diseases Collectively, we identified that hsa-miR3p, a miRNA induced in both circulation of AKI patients and hypoxia-reoxygenation-treated HK2 cells, enhanced renal inflammation by targeting HtrA3, which may suggest a possible role as a new therapeutic target for CSA-AKI. +lncRNA target 33462208 hsa-mir-6852 Carcinoma, Hepatocellular Through a series of screening and validation, we found that hsa_circ_0007456 mainly functioned through sponging miR +target gene 33462201 hsa-mir-541 Prostatic Neoplasms miR-541-3p enhances the radiosensitivity of prostate cancer cells by inhibiting HSP27 expression and downregulating β-catenin. +lncRNA target 33461652 hsa-let-7c Uterine Cervical Neoplasms Although it has been reported to exert a tumor suppressive effect in a variety of cancers, the exact role and mechanism of miR-let-7c-5p in the progression of cervical cancer are unclear. These findings provided a new anticancer strategy based on F-SiO(2) -polyethyleneimine/miR-let-7c-5p (FSP-let-7c-5p)nanoparticles and indicated that miR-let-7c-5p/IGF-1R/PI3K/AKT and -catenin/SLUG could be used as new potential targets for the treatment of cervical cancer. +circulation_biomarker_diagnosis_up 33461610 hsa-mir-206 Osteoporosis The expression level of serum miR-206 had diagnostic value for osteoporosis, and the serum miR-206 levels were positively correlated with BMD. +other 33461524 hsa-mir-210 Breast Neoplasms CONCLUSIONS: In summary, our findings identify miR-193 and miR-210 as potential regulatory miRNA in different molecular subtypes of breast cancer and suggest that miR-210 may have a specific role in MDA-MB-231 proliferation. +other 33461524 hsa-mir-193 Breast Neoplasms CONCLUSIONS: In summary, our findings identify miR-193 and miR-210 as potential regulatory miRNA in different molecular subtypes of breast cancer and suggest that miR-210 may have a specific role in MDA-MB-231 proliferation. +genetics_overexpression_promote 33461388 hsa-mir-143 Glioblastoma In addition, overexpression of miR-504 attenuated the effect of miR143HG overexpression on GBM cell proliferation. +exosome 33461167 hsa-mir-137 Hypoxia-Ischemia, Brain In conclusion, these results suggest that BV2-Exo alleviates ischemia-reperfusion brain injury through transporting exosomal miRNA-137. +lncRNA target 33461161 hsa-mir-494 Pulmonary Disease, Chronic Obstructive 3p expression can be induced by oxidative stress via the p38MAPK-c-myc signaling pathway, and miR +lncRNA target 33461070 hsa-mir-142 Pre-Eclampsia 3p regulated cell proliferation and migration through targeting FOXM1 in trophoblast cells, providing a novel therapeutic target and extending the pathogenesis of preeclampsia. +circulation_biomarker_diagnosis_up 33460661 hsa-mir-23 Coronary Disease 3p was observed to be highly-expressed in blood samples from patients with CHD or with mild atherosclerosis and in the rat model of CHD. +other 33460643 hsa-mir-1 Ischemic Stroke We also determined downstream signaling pathway of miR-31 in recovery of neurological function in ischemic stroke. In conclusion, miR-31 from ADSC-derived EVs can downregulate expression of TRAF6 and IRF5, leading to reduced neuronal damage induced by ischemic stroke. +other 33460628 hsa-mir-122 Non-alcoholic Fatty Liver Disease The increased triglyceride synthesis and decreased oxidative function of hepatocytes caused by low miR-122 expression due to dexamethasone could continue postnatally, eventually leading to NAFLD in adult rat offspring. +lncRNA target 33460398 hsa-mir-138 Rectal Prolapse Taken together, miR-138 could be a potential therapeutic target for treating POP in conjunction with tissue engineering. +other 33460397 hsa-mir-204 Gallbladder Neoplasms Here we explored miR-204 in patients with GC and related mechanisms. MiR-204 was low in patients with GC, and it might serve as a diagnostic indicator for GC. +other 33460343 hsa-mir-29a Diabetic Nephropathies Superoxide dismutase, catalase, glyoxalase1, and miR-29a expression decreased in diabetic groups and increased in treatment with GA. +genetics_knock down_promote 33460239 hsa-mir-4435-2 Carcinoma, Renal Cell Functionally, overexpression of MIR4435-2HG promoted the proliferation as well as the metastasis in ccRCC cell lines, whereas knockdown of MIR4435-2HG inhibited the above changes. +lncRNA target 33460027 hsa-mir-451a Small Cell Lung Carcinoma CONCLUSIONS: Our study indicated that miR-451a hinders SCLC cell proliferation in vitro through regulating mTOR and apoptosis signaling pathways via silencing HELLS, suggesting that miR-451a could be a promising tumor suppressor in SCLC. +lncRNA target 33459883 hsa-mir-146a Hepatitis A The results indicated that HAV infection upregulates the expression of hsa-miR-146a-5p, which in turn partially suppresses the induction of IFN-beta synthesis, thereby promoting viral replication. Taken together, the results from this study indicated that HAV disrupts RIG-I/MDA5-mediated IFN-I signaling partially through the cleavage of the essential adaptor molecule TRAF6 via hsa-miR-146a-5p. +genetics_overexpression_promote 33459391 hsa-mir-377 Esophageal Squamous Cell Carcinoma Overexpression of miR-377 could suppress the stem-like trait of ESCC as well as the tumor growth in vivo. +lncRNA target 33459380 hsa-mir-142 Lung Neoplasms 3p; circZNF609 enhanced LC cell proliferative and migrative ability via targeting miR +lncRNA target 33459377 hsa-mir-186 Glioblastoma We detected the HOXB-AS1-ILF3-HOXB2/HOXB3 axis and HOXB-AS1-miR5p-HOXB2/HOXB3 axis driving the GBM progression, which might generate more effective diagnostic biomarkers and therapeutic targets for patients with GBM. +lncRNA target 33459113 hsa-mir-144 Carcinoma, Non-Small-Cell Lung GAS6-AS2 suppression could inhibit the progression of NSCLC cells, and miR +genetics_overexpression_promote 33459111 hsa-mir-365 Gallbladder Neoplasms overexpression GBC cells and their control cells, which further demonstrated that RAC1 was involved in miR +lncRNA target 33459100 hsa-mir-558 Pulmonary Disease, Chronic Obstructive Herein, we attempted to investigate the function of miR-558/TNF Receptor Superfamily Member 1A (TNFRSF1A) in the progression of COPD. CONCLUSIONS: Up-regulation of miR-558 relieved the damage of HBE cells-triggered by CSE via reducing TNFRSF1A and inactivating TAK1/MAPK/NF-kappaB pathway, affording novel molecules for COPD treatment. +other 33458917 hsa-mir-1276 Corneal dystrophy, epithelial basement membrane Rescue experiments validated that circ_SMAD4 depended on miR-1276/TCF4-regulated CTNNB1 to elicit accelerating effects on GC cell growth. +other 33458739 hsa-mir-429 pancreatic ductal adenocarcinoma Epithelial to Mesenchymal Transition(EMT) Regulated by MicroRNA-429 in Pancreatic Ductal Adenocarcinoma (PDAC). +other 33457239 hsa-mir-137 Carcinoma, Renal Cell 3p and hsa-miR-137 may be notably related to hypertension-related RCC. +other 33457239 hsa-mir-205 Carcinoma, Renal Cell 3p and hsa-miR-137 may be notably related to hypertension-related RCC. +other 33457239 hsa-mir-221 Carcinoma, Renal Cell 3p and hsa-miR-137 may be notably related to hypertension-related RCC. +other 33457239 hsa-mir-152 Carcinoma, Renal Cell 3p and hsa-miR-137 may be notably related to hypertension-related RCC. +other 33457229 hsa-mir-429 Diabetic Nephropathies RESULTS: Four genes were associated with DN and RCC patients: the predicted miRNAs hsa-miR-200b-3p and hsa-miR-429 of fibronectin 1 (FN1); the predicted miRNA hsa-miR-29c-3p of collagen type 1 alpha 2 (COL1A2); the predicted miRNA hsa-miR-29c-3p of collagen type 3 alpha 1 (COL3A1); and the predicted miRNA hsa-miR-29a-3p and hsa-miR-200c-3p of glucosephosphatase catalytic subunit (G6PC). +other 33457229 hsa-mir-429 Carcinoma, Renal Cell RESULTS: Four genes were associated with DN and RCC patients: the predicted miRNAs hsa-miR-200b-3p and hsa-miR-429 of fibronectin 1 (FN1); the predicted miRNA hsa-miR-29c-3p of collagen type 1 alpha 2 (COL1A2); the predicted miRNA hsa-miR-29c-3p of collagen type 3 alpha 1 (COL3A1); and the predicted miRNA hsa-miR-29a-3p and hsa-miR-200c-3p of glucosephosphatase catalytic subunit (G6PC). +other 33457229 hsa-mir-200b Diabetic Nephropathies RESULTS: Four genes were associated with DN and RCC patients: the predicted miRNAs hsa-miR-200b-3p and hsa-miR-429 of fibronectin 1 (FN1); the predicted miRNA hsa-miR-29c-3p of collagen type 1 alpha 2 (COL1A2); the predicted miRNA hsa-miR-29c-3p of collagen type 3 alpha 1 (COL3A1); and the predicted miRNA hsa-miR-29a-3p and hsa-miR-200c-3p of glucosephosphatase catalytic subunit (G6PC). +other 33457229 hsa-mir-200b Carcinoma, Renal Cell RESULTS: Four genes were associated with DN and RCC patients: the predicted miRNAs hsa-miR-200b-3p and hsa-miR-429 of fibronectin 1 (FN1); the predicted miRNA hsa-miR-29c-3p of collagen type 1 alpha 2 (COL1A2); the predicted miRNA hsa-miR-29c-3p of collagen type 3 alpha 1 (COL3A1); and the predicted miRNA hsa-miR-29a-3p and hsa-miR-200c-3p of glucosephosphatase catalytic subunit (G6PC). +other 33457229 hsa-mir-29c Diabetic Nephropathies RESULTS: Four genes were associated with DN and RCC patients: the predicted miRNAs hsa-miR-200b-3p and hsa-miR-429 of fibronectin 1 (FN1); the predicted miRNA hsa-miR-29c-3p of collagen type 1 alpha 2 (COL1A2); the predicted miRNA hsa-miR-29c-3p of collagen type 3 alpha 1 (COL3A1); and the predicted miRNA hsa-miR-29a-3p and hsa-miR-200c-3p of glucosephosphatase catalytic subunit (G6PC). +other 33457229 hsa-mir-29c Carcinoma, Renal Cell RESULTS: Four genes were associated with DN and RCC patients: the predicted miRNAs hsa-miR-200b-3p and hsa-miR-429 of fibronectin 1 (FN1); the predicted miRNA hsa-miR-29c-3p of collagen type 1 alpha 2 (COL1A2); the predicted miRNA hsa-miR-29c-3p of collagen type 3 alpha 1 (COL3A1); and the predicted miRNA hsa-miR-29a-3p and hsa-miR-200c-3p of glucosephosphatase catalytic subunit (G6PC). +other 33457229 hsa-mir-29a Carcinoma, Renal Cell RESULTS: Four genes were associated with DN and RCC patients: the predicted miRNAs hsa-miR-200b-3p and hsa-miR-429 of fibronectin 1 (FN1); the predicted miRNA hsa-miR-29c-3p of collagen type 1 alpha 2 (COL1A2); the predicted miRNA hsa-miR-29c-3p of collagen type 3 alpha 1 (COL3A1); and the predicted miRNA hsa-miR-29a-3p and hsa-miR-200c-3p of glucosephosphatase catalytic subunit (G6PC). +other 33457229 hsa-mir-29a Diabetic Nephropathies RESULTS: Four genes were associated with DN and RCC patients: the predicted miRNAs hsa-miR-200b-3p and hsa-miR-429 of fibronectin 1 (FN1); the predicted miRNA hsa-miR-29c-3p of collagen type 1 alpha 2 (COL1A2); the predicted miRNA hsa-miR-29c-3p of collagen type 3 alpha 1 (COL3A1); and the predicted miRNA hsa-miR-29a-3p and hsa-miR-200c-3p of glucosephosphatase catalytic subunit (G6PC). +lncRNA target 33456986 hsa-mir-125b Esophageal Squamous Cell Carcinoma MiR-125b can stop the high growth and shifting of ESCC cells having p38-MAPK at target. +transcription factor target 33456665 hsa-mir-137 Microvascular Obstruction 3p/CAPN-2 interaction modulates neuronal apoptosis during IR injury, possibly by inhibiting CAPN-2, which leads to p35 cleavage and inhibition of subsequent p25/Cdk5 and caspase-8 overactivation. +other 33456584 hsa-mir-106b Squamous Cell Carcinoma of Head and Neck miR-106b-5p, miR5p and miR-193b-3p were expressed at high levels in saliva of OSCC patients and their combination displays the best diagnostic performance (ROC - AUC = 0.98). +other 33456584 hsa-mir-193b Squamous Cell Carcinoma of Head and Neck miR-106b-5p, miR5p and miR-193b-3p were expressed at high levels in saliva of OSCC patients and their combination displays the best diagnostic performance (ROC - AUC = 0.98). +other 33456584 hsa-mir-423 Squamous Cell Carcinoma of Head and Neck miR-106b-5p, miR5p and miR-193b-3p were expressed at high levels in saliva of OSCC patients and their combination displays the best diagnostic performance (ROC - AUC = 0.98). +other 33456572 hsa-mir-7975 Sexually Transmitted Diseases Interestingly, NDTRs contained proinflammatory miRNAs such as miR-1260, miR-1285, miR-4454, and miR-7975, while NDMVs contained anti-inflammatory miRNAs such as miR-126, miR-150, and miR-451a. +other 33456572 hsa-mir-7975 Neuroleptic Malignant Syndrome Interestingly, NDTRs contained proinflammatory miRNAs such as miR-1260, miR-1285, miR-4454, and miR-7975, while NDMVs contained anti-inflammatory miRNAs such as miR-126, miR-150, and miR-451a. +other 33456572 hsa-mir-7975 Inflammation Interestingly, NDTRs contained proinflammatory miRNAs such as miR-1260, miR-1285, miR-4454, and miR-7975, while NDMVs contained anti-inflammatory miRNAs such as miR-126, miR-150, and miR-451a. +other 33456572 hsa-mir-4454 Inflammation Interestingly, NDTRs contained proinflammatory miRNAs such as miR-1260, miR-1285, miR-4454, and miR-7975, while NDMVs contained anti-inflammatory miRNAs such as miR-126, miR-150, and miR-451a. +other 33456572 hsa-mir-4454 Sexually Transmitted Diseases Interestingly, NDTRs contained proinflammatory miRNAs such as miR-1260, miR-1285, miR-4454, and miR-7975, while NDMVs contained anti-inflammatory miRNAs such as miR-126, miR-150, and miR-451a. +other 33456572 hsa-mir-1260 Neuroleptic Malignant Syndrome Interestingly, NDTRs contained proinflammatory miRNAs such as miR-1260, miR-1285, miR-4454, and miR-7975, while NDMVs contained anti-inflammatory miRNAs such as miR-126, miR-150, and miR-451a. +other 33456572 hsa-mir-4454 Neuroleptic Malignant Syndrome Interestingly, NDTRs contained proinflammatory miRNAs such as miR-1260, miR-1285, miR-4454, and miR-7975, while NDMVs contained anti-inflammatory miRNAs such as miR-126, miR-150, and miR-451a. +other 33456572 hsa-mir-1285 Neuroleptic Malignant Syndrome Interestingly, NDTRs contained proinflammatory miRNAs such as miR-1260, miR-1285, miR-4454, and miR-7975, while NDMVs contained anti-inflammatory miRNAs such as miR-126, miR-150, and miR-451a. +other 33456572 hsa-mir-150 Neuroleptic Malignant Syndrome Interestingly, NDTRs contained proinflammatory miRNAs such as miR-1260, miR-1285, miR-4454, and miR-7975, while NDMVs contained anti-inflammatory miRNAs such as miR-126, miR-150, and miR-451a. +other 33456572 hsa-mir-1260 Sexually Transmitted Diseases Interestingly, NDTRs contained proinflammatory miRNAs such as miR-1260, miR-1285, miR-4454, and miR-7975, while NDMVs contained anti-inflammatory miRNAs such as miR-126, miR-150, and miR-451a. +other 33456572 hsa-mir-1260 Inflammation Interestingly, NDTRs contained proinflammatory miRNAs such as miR-1260, miR-1285, miR-4454, and miR-7975, while NDMVs contained anti-inflammatory miRNAs such as miR-126, miR-150, and miR-451a. +other 33456572 hsa-mir-1285 Sexually Transmitted Diseases Interestingly, NDTRs contained proinflammatory miRNAs such as miR-1260, miR-1285, miR-4454, and miR-7975, while NDMVs contained anti-inflammatory miRNAs such as miR-126, miR-150, and miR-451a. +other 33456572 hsa-mir-150 Inflammation Interestingly, NDTRs contained proinflammatory miRNAs such as miR-1260, miR-1285, miR-4454, and miR-7975, while NDMVs contained anti-inflammatory miRNAs such as miR-126, miR-150, and miR-451a. +other 33456572 hsa-mir-150 Sexually Transmitted Diseases Interestingly, NDTRs contained proinflammatory miRNAs such as miR-1260, miR-1285, miR-4454, and miR-7975, while NDMVs contained anti-inflammatory miRNAs such as miR-126, miR-150, and miR-451a. +other 33456572 hsa-mir-1285 Inflammation Interestingly, NDTRs contained proinflammatory miRNAs such as miR-1260, miR-1285, miR-4454, and miR-7975, while NDMVs contained anti-inflammatory miRNAs such as miR-126, miR-150, and miR-451a. +other 33456570 hsa-mir-125a Heart Failure Deletion of 12/15LOX differentially modulated the miRNA levels, downregulating miR-23a-3p (~20 fold; p < 0.05) and upregulating miR-125a-5p (~160 fold; p < 0.05) in AHF which promoted polarization of the macrophages towards reparative phenotype. +other 33456570 hsa-mir-23a Heart Failure Deletion of 12/15LOX differentially modulated the miRNA levels, downregulating miR-23a-3p (~20 fold; p < 0.05) and upregulating miR-125a-5p (~160 fold; p < 0.05) in AHF which promoted polarization of the macrophages towards reparative phenotype. +lncRNA target 33456538 hsa-mir-140 Arthritis, Rheumatoid Therefore, the current findings indicated that miR-140 is a crucial modulator of both proliferation and apoptosis, shedding light on the etiology behind RA FLS viability, which is modulated by an interplay between miR-140 and STAT3 in the context of RA. +lncRNA target 33456536 hsa-mir-21 Liver Cirrhosis 5p may be an effective anti-fibrosis target. +circulation_biomarker_diagnosis_up 33456529 hsa-mir-155 Mucocutaneous Lymph Node Syndrome Except for NLR and CRP, there were differences in the expression of peripheral blood miRNA-145, miRNA-155 and serum TNF-alpha and IL-6 in patients with immunoglobulin-sensitive and -insensitive incomplete KD. +circulation_biomarker_diagnosis_up 33456529 hsa-mir-145 Mucocutaneous Lymph Node Syndrome Except for NLR and CRP, there were differences in the expression of peripheral blood miRNA-145, miRNA-155 and serum TNF-alpha and IL-6 in patients with immunoglobulin-sensitive and -insensitive incomplete KD. +genetics_overexpression_promote 33456519 hsa-mir-490 Acute Lung Injury 3p overexpression significantly inhibited LPS-induced ALI and inflammatory responses by restricting the IRAK1/TRAF6 pathway. +other 33456517 hsa-mir-129 Choledocholithiasis The 102911/miR5p/SOX6 axis was found to be involved in T lymphocytes immune function, which provided a novel insight for the treatment of elderly patients with hepatolithiasis. +circulation_biomarker_prognosis_up 33456356 hsa-mir-760 Carcinoma, Hepatocellular 5p and hsa-miR-760 were distinctly increased in the plasma of HCC patients. +circulation_biomarker_prognosis_up 33456356 hsa-mir-7 Carcinoma, Hepatocellular 5p and hsa-miR-760 were distinctly increased in the plasma of HCC patients. +circulation_biomarker_prognosis_up 33456356 hsa-mir-139 Carcinoma, Hepatocellular 5p and hsa-miR-760 were distinctly increased in the plasma of HCC patients. +transcription factor target 33456354 hsa-mir-15a Atherosclerosis In conclusion, miR-15a-5p may be the therapeutic target of the pathological basis of coronary atherosclerosis. +lncRNA target 33456347 hsa-mir-182 Hallux Valgus Moreover, miR-182 might potentially be a therapeutic target for hallux valgus treatment. +lncRNA target 33455522 hsa-mir-196b Adenocarcinoma of Lung CONCLUSION: MiR-196b promotes the invasion and migration of LUAD cells by down-regulating AQP4, which helps us find new molecular targeted therapies for LUAD. +genetics_overexpression_promote 33455114 hsa-mir-218 Uterine Cervical Neoplasms After overexpression of miR-218, the proliferation ability of the CC cells was weakened, and the migration and invasion of CC cells were repressed. +genetics_overexpression_promote 33455113 hsa-mir-21 Stomach Neoplasms In addition, Kaplan-Meier and log-rank test revealed lower progression-free survival (PFS) and overall survival (OS) in GC patients overexpressing miR +lncRNA target 33455111 hsa-mir-141 Colonic Neoplasms CONCLUSIONS: MiR-141 may promote proliferation and reduce apoptosis of colon cancer cells via targeting Sirt1. +transcription factor target 33455109 hsa-mir-466 Lung Neoplasms CONCLUSION: Taken all together, miR-466 suppression is associated with the growth and progression of lung cancer. +other 33455104 hsa-mir-128 Prostatic Neoplasms METHODS: The levels of PVT1-214, microRNA (miR)-128, and interferon regulatory factor-1 (IRF-1) in CRC tissues and cell lines were evaluated by quantitative real-time polymerase chain reaction (qRT-PCR). +genetics_overexpression_suppress 33455101 hsa-mir-489 Glioblastoma The proliferative capacity of GBM cells was enhanced notably after inhibiting the expression of miR-489 (p<0.01), while it was obviously weakened by overexpressed miR-489 or TWIST1-siRNA (p<0.01). +lncRNA target 33454992 hsa-mir-146a Femur Head Necrosis The results of our study suggest that Res prevents steroid-induced osteonecrosis by upregulating miR-146a, and thereby stabilizes osteogenesis/osteoclastogenesis homeostasis via Wnt/FOXO and Sirt1/NF-kappaB pathways. +genetics_overexpression_promote 33454903 hsa-mir-27b Fibrosis, Renal In conclusion, miR-27b-3p overexpression could alleviate renal fibrosis via suppressing STAT1 in vivo and in vitro. +other 33454892 hsa-mir-146a Mitochondrial Diseases We performed a thorough screening and analysis of the impact of cadmium chloride (CdCl(2)) and N-acetylcysteine (NAC) on the miR146a/NF-kappaB p65 inflammatory pathway and mitochondrial biogenesis dysfunction in male albino rats. +other 33454555 hsa-mir-1301 Thyroid Cancer, Papillary 3p may serve as a potential biomarker for the early diagnosis and treatment of PTC. +other 33453713 hsa-mir-133a Trophoblastic Neoplasms This regulatory mechanism of miR-133a-3p in the trophoblast cells under oxidative stress may give a new perspective for oxidative stress-induced trophoblast cell abnormality and be useful to study more pathological mechanisms of PE. +other 33453713 hsa-mir-133a Pneumonia, Mycoplasma This regulatory mechanism of miR-133a-3p in the trophoblast cells under oxidative stress may give a new perspective for oxidative stress-induced trophoblast cell abnormality and be useful to study more pathological mechanisms of PE. +lncRNA target 33453674 hsa-mir-34 Arthritis Hence, the study aimed to inspect the ability of the combination therapy of metformin and omega-3 to modulate different signaling pathways and micro RNAs such as (miR-155, miR-146a and miR-34) as new targets in order to mitigate adjuvant-induced arthritis and compare their effect to that of methotrexate. +lncRNA target 33453674 hsa-mir-155 Arthritis Hence, the study aimed to inspect the ability of the combination therapy of metformin and omega-3 to modulate different signaling pathways and micro RNAs such as (miR-155, miR-146a and miR-34) as new targets in order to mitigate adjuvant-induced arthritis and compare their effect to that of methotrexate. +lncRNA target 33453674 hsa-mir-146a Arthritis Hence, the study aimed to inspect the ability of the combination therapy of metformin and omega-3 to modulate different signaling pathways and micro RNAs such as (miR-155, miR-146a and miR-34) as new targets in order to mitigate adjuvant-induced arthritis and compare their effect to that of methotrexate. +transcription factor target 33453444 hsa-mir-224 Femur Head Necrosis 5p antagomir could alleviate the inhibitory effects of GCs and facilitate bone formation in steroid-induced ONFH models. +genetics_GWAS 33453248 hsa-mir-34a Breast Neoplasms It can be concluded that miR-34a and miR-520h are implicated in the apoptosis pathways, and thus, VPA can recruit as a possible option in breast cancer research due to its interference with epigenetic processes. +genetics_GWAS 33453248 hsa-mir-520h Breast Neoplasms It can be concluded that miR-34a and miR-520h are implicated in the apoptosis pathways, and thus, VPA can recruit as a possible option in breast cancer research due to its interference with epigenetic processes. +genetics_knock down_promote 33453148 hsa-mir-145 Carcinoma, Renal Cell 5p inhibitor significantly attenuated the effect of circPVT1 knockdown on ccRCC cells. +circulation_biomarker_diagnosis_ns 33452935 hsa-mir-106a Multiple Sclerosis Experimental validation using real-time PCR assay was carried to verifying the miR-106a-5p expression in MS and healthy control blood samples. +transcription factor target 33452670 hsa-mir-144 Reperfusion Injury 3p/ANO1 axis may be a putative therapeutic target in myocardial ischemia. +lncRNA target 33452572 hsa-mir-206 Hypersensitivity CONCLUSIONS: UA treatment significantly relieved the injury of Nthy-ori 3-1 cells via inhibiting the ceRNA mechanism of MALAT1/miR-206/PTGS1 and inflammatory pathways, insinuating that UA may be helpful for the treatment of AIT. +exosome 33450254 hsa-mir-375 Colonic Neoplasms SIGNIFICANCE: Our results imply that colon cancer cells-derived exosomes could be used as an effective nonvehicle to deliver miR3p mimic. +transcription factor target 33450181 hsa-mir-185 Hepatitis C Additionally, inhibition of one miR-185 target, monoglyceride lipase, led to decreased hepatitis C virus levels in an infectious model. +other 33450179 hsa-mir-690 Obesity Taken together, these data suggest miR-690 could be a new therapeutic insulin-sensitizing agent for metabolic disease. +genetics_knock down_promote 33450101 hsa-mir-384 Prostatic Neoplasms The effects of SNHG8 knockdown on PCa cell proliferation, migration and invasion were counteracted by miR-384 inhibition. CONCLUSIONS: SNHG8 promotes PCa cell proliferation, migration and invasion via decoying miR-384 and up-regulating HOXB7. +lncRNA target 33450091 hsa-mir-19a Colorectal Neoplasms METHODS: The relative expression of MCM3AP-AS1, miR-19a-3p and forkhead box F2 (FOXF2) mRNA in 53 cases of CRC and its adjacent normal tissues, human normal colonic mucosal cells (FHC cells) and CRC cell lines was examined by a quantitative real-time polymerase chain reaction, and the changes of cell multiplication and migration were examined by the cell counting kit-8 method, EdU test, and scratch-healing test, respectively. CONCLUSIONS: MCM3AP-AS1 can inhibit CRC promoting by modulating the miR-19a-3p/FOXF2 axis. +genetics_overexpression_promote 33449226 hsa-mir-539 Stomach Neoplasms 3p inhibitor could reverse the suppressive effect of circ_0004104 silencing on GC progression, and RNF2 overexpression also reversed the inhibition effect of miR +target gene 33449106 hsa-mir-93 Breast Neoplasms EYA2 upregulates miR-93 to promote tumorigenesis of breast cancer by targeting and inhibiting the STING signaling pathway. +lncRNA target 33448691 hsa-mir-32 Glioma 5p or upregulated SOX4 could markedly counteract the inhibitory effects of silencing HNF1A-AS1 on glioma malignant biological behaviors. +lncRNA target 33448372 hsa-mir-3473b Parkinson Disease The regulatory role of a variety of microRNAs in PD has been confirmed, and our study is the first to demonstrate that miR-3473b is involved in the regulation of PD. Thus, miR-3473b may regulate the secretion of proinflammatory mediators by targeting TREM2/ULK1 expression to regulate the role of autophagy in the pathogenesis of inflammation in Parkinson's disease, suggesting that mir-3473b may be a potential therapeutic target to regulate the inflammatory response in PD. +circulation_biomarker_diagnosis_up 33448324 hsa-mir-101 Cardiomyopathies The results revealed that miR1013p was upregulated in the serum of patients with sepsisinduced cardiomyopathy (SIC) and positively correlated with the levels of proinflammatory cytokines (including IL1beta, IL6 and TNFalpha). +circulation_biomarker_diagnosis_up 33448324 hsa-mir-101 Myocardial Injury The results revealed that miR1013p was upregulated in the serum of patients with sepsisinduced cardiomyopathy (SIC) and positively correlated with the levels of proinflammatory cytokines (including IL1beta, IL6 and TNFalpha). +lncRNA target 33448322 hsa-mir-152 Arthritis The present data indicated that lncRNAS56464.1 could target the miR1523p/Wnt pathway to induce synovial cell proliferation and then participate in the pathogenesis of RA. +genetics_knock down_promote 33448321 hsa-mir-25 Multiple Myeloma Further analyses revealed that the overexpression of PTEN exerted effects similar to those of miR253p knockdown, whereas the knockdown of PTEN partially abolished the effects of miR253p inhibitor on MM cells. +genetics_overexpression_promote 33448310 hsa-mir-93 Esophageal Neoplasms Furthermore, it was found that the simultaneous overexpression of miR935p and TGFR2 almost had no effect on the biological behaviors of EC cells. +other 33448307 hsa-mir-532 Heart Failure We concluded that MALAT1 upregulated LDLR expression by competitively binding to miR5323p, thereby increasing pathological injury in HF. +other 33448307 hsa-mir-532 Adenocarcinoma of Lung We concluded that MALAT1 upregulated LDLR expression by competitively binding to miR5323p, thereby increasing pathological injury in HF. +lncRNA target 33448171 hsa-mir-199a Ischemic Stroke RESULTS: BYHWD treatment significantly promoted the recovery of neurological function (P<0.05 or P<0.01), reduced the infarct volume (P<0.05), increased the number of BrdU(+)/DCX(+), BrdU(+)/NeuN(+) and BrdU(+)/vWF(+) cells (all P<0.01), upregulated the expression of miR-199a-5p (P<0.01), and increased the protein expression of VEGF and BDNF at d14 after cerebral ischemia (all P<0.05). CONCLUSIONS: Buyang Huanwu decoction promotes neurogenesis and angiogenesis in rats with cerebral ischemia, which may be related to increased protein expression of VEGF and BDNF through upregulating miR-199a-5p. +genetics_overexpression_promote 33447989 hsa-mir-590 Squamous Cell Carcinoma of Head and Neck RESULTS Overexpression of miR +circulation_biomarker_diagnosis_up 33447883 hsa-mir-150 Anemia, Aplastic 5p is an immune-related miRNA and elevated in the plasma of patients with aplastic anemia (AA), but its role in T cell activation in patients with severe aplastic anemia (SAA) is unclear. +other 33447879 hsa-mir-146a Carcinoma, Small Cell Moreover, miR-146a-3p, which significantly decreased during the differentiation of hAMSCs into SCLCs, was selected by miRNA-sequence analysis. +lncRNA target 33447565 hsa-mir-183 Pituitary Neoplasms Background This study aims to investigate the mechanism through which Caveolin-1 (CAV-1) regulates the expression of micro ribonucleic acid (miR)-183 in invasive pituitary adenoma (IPA) tissues and GH3 cells, and explore the effects of CAV-1 and miR-183 on the invasion and migration ability of GH3 cells. +other 33447542 hsa-mir-29a Adenoma, Pleomorphic CONCLUSIONS: There was a sufficiently high level of miR-34a and miR-29a expressions in the tissues of the tumor of pleomorphic adenomas of the salivary glands when compared with the intact salivary gland tissue. +other 33447542 hsa-mir-34a Adenoma, Pleomorphic CONCLUSIONS: There was a sufficiently high level of miR-34a and miR-29a expressions in the tissues of the tumor of pleomorphic adenomas of the salivary glands when compared with the intact salivary gland tissue. +circulation_biomarker_diagnosis_ns 33447421 hsa-mir-130 Myocardial Infarction, Acute CONCLUSIONS: These results indicate that circulating miR-130 holds great promise as an effective biomarker for diagnosing AMI earlier. +circulation_biomarker_diagnosis_up 33447132 hsa-mir-141 Carcinoma, Ovarian Epithelial CONCLUSION: The miR-141 was upregulated in the blood plasma of EOC and associated with an advanced stage of disease, suggesting it has potential as a biomarker for EOC detection. +genetics_knock down_promote 33447074 hsa-mir-21 Carcinoma, Squamous Cell, Cutaneous Loss-of-function assays were performed in cells to explore the independent and combined functions of miR-21 and TIMP3 in CSCC cell progression. +target gene 33447060 hsa-mir-1 Colorectal Neoplasms the TGF-β1 treatment down-regulated NAMPT expression at mRNA and protein levels in CRC cells which were partly through the up-regulation of miR-1-3p that directly bound to the NAMPT 3'-UTR. +lncRNA target 33447058 hsa-mir-137 Carcinoma, Hepatocellular CONCLUSION: Our findings suggested that miR-137 inhibited HCC tumor growth and progression via interacting with DNMT3a and suppressing the PTEN/Akt signaling in vitro and in vivo. +lncRNA target 33447057 hsa-mir-499b Glioma RWDD4 was upregulated in glioma while miR-499b-5p was downregulated. CONCLUSION: DDX11-AS1 upregulation promotes glioma progression through acting as a competing endogenous RNA for miR-499b-5p to upregulate RWDD4. +target gene 33447050 hsa-mir-145 Pancreatic Neoplasms lncRNA BC037916 positively regulated the expression of Twist through miR-3145-3p +circulation_biomarker_diagnosis_ns 33447019 hsa-mir-125b Cognitive Dysfunction Conclusion Circulating miR-124a, miR +circulation_biomarker_diagnosis_ns 33447019 hsa-mir-142 Cognitive Dysfunction Conclusion Circulating miR-124a, miR +circulation_biomarker_diagnosis_ns 33447019 hsa-mir-483 Cognitive Dysfunction Conclusion Circulating miR-124a, miR +circulation_biomarker_diagnosis_ns 33447019 hsa-mir-124a Cognitive Dysfunction Conclusion Circulating miR-124a, miR +exosome 33446893 hsa-mir-10b Glioma and miR-10b-5p-rich exosomes that are delivered to normoxic glioma cells to promote their migration and invasion; treatment targeting miR-1246 and miR-10b-5p may impair the motility of gliomas, providing a novel direction for the development of antitumor therapy. +exosome 33446893 hsa-mir-1246 Glioma and miR-10b-5p-rich exosomes that are delivered to normoxic glioma cells to promote their migration and invasion; treatment targeting miR-1246 and miR-10b-5p may impair the motility of gliomas, providing a novel direction for the development of antitumor therapy. +epigenetics 33446575 hsa-mir-483 Obesity Furthermore, SOS1 was posttranscriptionally regulated by miR-483 whose expression is reduced in AA patients through histone trimethylation (H3K27me3) on its promoter. +epigenetics 33446575 hsa-mir-483 Breast Neoplasms Furthermore, SOS1 was posttranscriptionally regulated by miR-483 whose expression is reduced in AA patients through histone trimethylation (H3K27me3) on its promoter. +other 33446250 hsa-mir-142 Intervertebral Disc Degeneration 3p in IDD development. +circulation_biomarker_diagnosis_up 33446221 hsa-let-7a Colorectal Neoplasms RESULTS: let-7a miRNA was elevated in serum EVs from CRC patients and was enriched in CRC cell-derived EVs. +other 33446212 hsa-mir-93 Polycystic Ovary Syndrome Sensitivity analysis showed that the expression of miR-93 was upregulated in PCOS patients (WMD 0.75, P < 0.00001), without heterogeneity among remaining studies (I(2) = 0%). +other 33446130 hsa-mir-34a Gastrointestinal Neoplasms MiR-34a may become a new factor for the prognosis prediction and progression of GICs. +circulation_biomarker_diagnosis_up 33446013 hsa-mir-146a Sjogren's Syndrome In clinical practice, we found that microRNA (miR)-146a-5p is significantly up-regulated in peripheral blood mononuclear cells (PBMCs) of primary sjogren's syndrome (pSS) patients. Our results revealed a significantly increased expression of miR-146a-5p in PBMCs from pSS patients and significantly increased percentage of Th17 cells compared to PBMCs from healthy controls. +other 33445780 hsa-mir-142 Epilepsy, Temporal Lobe In detail, miR-142 expression was 0.40 /- 0.29 versus 0.16 /- 0.10 in TLE patients compared to HC (t-test, p < 0.01), miR-146a expression was 0.15 /- 0.11 versus 0.07 /- 0.04 (t-test, p < 0.05), and miR-223 expression was 6.21 /- 3.65 versus 1.23 /- 0.84 (t-test, p < 0.001). +other 33445780 hsa-mir-146a Epilepsy, Temporal Lobe In detail, miR-142 expression was 0.40 /- 0.29 versus 0.16 /- 0.10 in TLE patients compared to HC (t-test, p < 0.01), miR-146a expression was 0.15 /- 0.11 versus 0.07 /- 0.04 (t-test, p < 0.05), and miR-223 expression was 6.21 /- 3.65 versus 1.23 /- 0.84 (t-test, p < 0.001). +other 33445780 hsa-mir-223 Epilepsy, Temporal Lobe In detail, miR-142 expression was 0.40 /- 0.29 versus 0.16 /- 0.10 in TLE patients compared to HC (t-test, p < 0.01), miR-146a expression was 0.15 /- 0.11 versus 0.07 /- 0.04 (t-test, p < 0.05), and miR-223 expression was 6.21 /- 3.65 versus 1.23 /- 0.84 (t-test, p < 0.001). +other 33445738 hsa-let-7e Diabetes Mellitus, Type 2 3p). +other 33445738 hsa-let-7d Prediabetic State 3p). +other 33445738 hsa-mir-146b Diabetes Mellitus, Type 2 3p). +other 33445738 hsa-let-7e Prediabetic State 3p). +other 33445738 hsa-mir-342 Diabetes Mellitus, Type 2 3p). +other 33445738 hsa-mir-342 Prediabetic State 3p). +other 33445738 hsa-mir-10a Diabetes Mellitus, Type 2 3p). +other 33445738 hsa-mir-146b Prediabetic State 3p). +other 33445738 hsa-mir-127 Prediabetic State 3p). +other 33445738 hsa-mir-127 Diabetes Mellitus, Type 2 3p). +other 33445738 hsa-mir-10a Prediabetic State 3p). +other 33445738 hsa-mir-125b Diabetes Mellitus, Type 2 3p). +other 33445738 hsa-mir-125b Prediabetic State 3p). +other 33445738 hsa-mir-365a Diabetes Mellitus, Type 2 3p). +other 33445738 hsa-mir-365a Prediabetic State 3p). +other 33445738 hsa-let-7a Prediabetic State 3p). +other 33445738 hsa-let-7a Diabetes Mellitus, Type 2 3p). +other 33445738 hsa-let-7d Diabetes Mellitus, Type 2 3p). +other 33445560 hsa-mir-206 Muscular Dystrophies, Limb-Girdle This study provides the first evidence that miR-206 is associated with phenotypic expression and it could be used as a prognostic indicator of LGMD disease progression. +transcription factor target 33445508 hsa-mir-181b Leukemia, Lymphocytic, Chronic, B-Cell We demonstrate that activated CD4+ T cells increase miR-181b expression in CLL through CD40-CD40L signaling, which enhances the maturation and activity of cytotoxic T cells and, consequently, the apoptotic response of CLL cells. +circulation_biomarker_diagnosis_up 33445213 hsa-mir-126 Diabetes Mellitus, Type 2 Therefore, we aimed to determine the effects of astaxanthin (AST) supplementation on the circulating malondialdehyde (MDA) and interleukin 6 (IL-6) levels, and the expression of miR-146a and miR-126 in patients with T2DM. +circulation_biomarker_diagnosis_up 33445213 hsa-mir-146a Diabetes Mellitus, Type 2 Therefore, we aimed to determine the effects of astaxanthin (AST) supplementation on the circulating malondialdehyde (MDA) and interleukin 6 (IL-6) levels, and the expression of miR-146a and miR-126 in patients with T2DM. +lncRNA target 33444948 hsa-mir-152 Stomach Neoplasms CONCLUSIONS: CircPVT1 regulated the chemoresistance and malignancy of GC through modulating HDGF expression via sponging miR +lncRNA target 33444919 hsa-mir-200a Fibrosis In conclusion, helenalin inhibits HSC activation via inhibiting the miR-200a-mediated PI3K/Akt and NF-kappaB pathways, and it may be developed as a potential medicine for the treatment of liver fibrosis. +genetics_GWAS 33444631 hsa-mir-1202 COVID-19 rs140092351, a SNP on microRNA miR1202, not only had the most significant association with COVID-19, but also interacted with multiple exposure factors. +genetics_GWAS 33442421 hsa-mir-1262 gastric cardia adenocarcinoma Our findings demonstrate miR-1262 transcriptionally modulated by an enhancer genetic variant suppresses GCA via targeting oncogene ULK1. +lncRNA target 33442418 hsa-mir-214 Esophageal Neoplasms Furthermore, CDC25B was a direct target of miR-214, and FAM83A-AS1 enhanced CDC25B expression while miR-214 positively CDC25B expression in ESCC. +genetics_overexpression_promote 33442412 hsa-mir-202 Pancreatic Carcinoma Overexpression of miR-202 in PC cells reduced cell proliferation and tumorigenesis by impairing glycolysis, while downregulation of miR-202 promoted the cells proliferative capacity. +lncRNA target 33442405 hsa-mir-197 Esophageal Squamous Cell Carcinoma In summary, our findings suggest that lncRNA FAM225A promotes ESCC development and progression via sponging miR +genetics_knock down_promote 33442296 hsa-mir-384 Carcinoma, Non-Small-Cell Lung CONCLUSION: We demonstrated that circ_0020123 knockdown suppressed NSCLC cell progression by regulating the miR-384/TRIM44 axis, providing the theoretical basis for the therapy of NSCLC. +exosome 33442291 hsa-mir-375 Prostatic Neoplasms Moreover, PCa patients can be distinguished from patients with benign prostatic hyperplasia by using a panel combining urinary exosomal miR-375 and miR-451a with an AUC of 0.726. +exosome 33442291 hsa-mir-451a Prostatic Neoplasms Moreover, PCa patients can be distinguished from patients with benign prostatic hyperplasia by using a panel combining urinary exosomal miR-375 and miR-451a with an AUC of 0.726. +lncRNA target 33442289 hsa-mir-1253 Breast Neoplasms CONCLUSION: Circ_0004771 accelerated cell carcinogenic phenotypes via up-regulating DDAH1 expression through absorbing miR-1253 in BC. +circRNA target 33442269 hsa-mir-570 Ovarian Neoplasms CONCLUSION: circ_0007444 is a tumor suppressor in OC, which inhibits OC progression by mediating the miR +genetics_overexpression_promote 33442268 hsa-mir-1299 Prostatic Neoplasms induced effects in PCa cells were largely attenuated by CFL2 overexpression. +other 33442267 hsa-mir-503 Lung Neoplasms Silencing of MicroRNA-503 in Rat Mesenchymal Stem Cells Exerts Potent Antitumorigenic Effects in Lung Cancer Cells. +target gene 33442263 hsa-mir-1225 Osteosarcoma MiRNA-1225 Inhibits Osteosarcoma Tumor Growth and Progression by Targeting YWHAZ. +lncRNA target 33442262 hsa-mir-490 Osteosarcoma 3p suppression or HMGA2 restoration abated CCDC144NL-AS1 deficiency-induced cancer-inhibitory actions in OS cells. +lncRNA target 33442254 hsa-mir-488 Ischemic Stroke, Cerebral Meanwhile, this inhibition strengthened positive impact generated by miR +transcription factor target 33441699 hsa-mir-148a Seizures, Febrile Furthermore, miR-148a-3p acted as a apoptosis enhcaner via the activation of the SYNJ1/PI3K/Akt signaling pathway, highlighting a potential therapeutic target in the treatment of infants with hyperthermia-induced brain injury. +transcription factor target 33441699 hsa-mir-148 Seizures, Febrile Furthermore, miR-148a-3p acted as a apoptosis enhcaner via the activation of the SYNJ1/PI3K/Akt signaling pathway, highlighting a potential therapeutic target in the treatment of infants with hyperthermia-induced brain injury. +other 33441208 hsa-mir-4491 Echinococcosis Compared with the control group, expression of 6 miRNAs (hsa-miR-4659a-5p, hsa-miR-4518, hsa-miR-3977, hsa-miR-4692, hsa-miR-181b-3p, hsa-miR-4491) and one miRNA (hsa-miR5p) were found to be downregulated in CE patients with active and inactive cysts, respectively (p < 0.05). +other 33441208 hsa-mir-4692 Echinococcosis Compared with the control group, expression of 6 miRNAs (hsa-miR-4659a-5p, hsa-miR-4518, hsa-miR-3977, hsa-miR-4692, hsa-miR-181b-3p, hsa-miR-4491) and one miRNA (hsa-miR5p) were found to be downregulated in CE patients with active and inactive cysts, respectively (p < 0.05). +other 33441208 hsa-mir-4518 Echinococcosis Compared with the control group, expression of 6 miRNAs (hsa-miR-4659a-5p, hsa-miR-4518, hsa-miR-3977, hsa-miR-4692, hsa-miR-181b-3p, hsa-miR-4491) and one miRNA (hsa-miR5p) were found to be downregulated in CE patients with active and inactive cysts, respectively (p < 0.05). +other 33441208 hsa-mir-4687 Echinococcosis Compared with the control group, expression of 6 miRNAs (hsa-miR-4659a-5p, hsa-miR-4518, hsa-miR-3977, hsa-miR-4692, hsa-miR-181b-3p, hsa-miR-4491) and one miRNA (hsa-miR5p) were found to be downregulated in CE patients with active and inactive cysts, respectively (p < 0.05). +other 33441208 hsa-mir-3977 Echinococcosis Compared with the control group, expression of 6 miRNAs (hsa-miR-4659a-5p, hsa-miR-4518, hsa-miR-3977, hsa-miR-4692, hsa-miR-181b-3p, hsa-miR-4491) and one miRNA (hsa-miR5p) were found to be downregulated in CE patients with active and inactive cysts, respectively (p < 0.05). +other 33441208 hsa-mir-4659a Echinococcosis Compared with the control group, expression of 6 miRNAs (hsa-miR-4659a-5p, hsa-miR-4518, hsa-miR-3977, hsa-miR-4692, hsa-miR-181b-3p, hsa-miR-4491) and one miRNA (hsa-miR5p) were found to be downregulated in CE patients with active and inactive cysts, respectively (p < 0.05). +other 33441208 hsa-mir-181b Echinococcosis Compared with the control group, expression of 6 miRNAs (hsa-miR-4659a-5p, hsa-miR-4518, hsa-miR-3977, hsa-miR-4692, hsa-miR-181b-3p, hsa-miR-4491) and one miRNA (hsa-miR5p) were found to be downregulated in CE patients with active and inactive cysts, respectively (p < 0.05). +other 33441016 hsa-mir-19b-1 Cerebrovascular Disorders 5p could be a suitable marker for aspirin resistance and might predict recurrence of MACCE in patients with ACS. +other 33441016 hsa-mir-19b-1 Acute Coronary Syndrome 5p could be a suitable marker for aspirin resistance and might predict recurrence of MACCE in patients with ACS. +lncRNA target 33440989 hsa-mir-129 Multiple Myeloma Magnolol suppressed cell migration and invasion and induced cell apoptosis via inhibiting NF-kappaB pathway activation, by upregulating miR-129 in MM. +genetics_knock down_promote 33440987 hsa-mir-1297 Glioma The hsa_circ_0030018 knockdown repressed glioma progression by mediating the miR-1297/RAB21 pathway, providing potential therapeutic targets for glioma treatment. +other 33440868 hsa-mir-429 Breast Neoplasms The AUC for each DE miRNA, miR-10b, miR-21, miR-96, miR-99a, miR-100, miR-125b-1, miR-125b-2, miR-139, miR-141, miR-145, miR-182, miR-183, miR-195, miR-200a, miR-337, miR-429, and let-7c, exceeded 0.9, indicating excellent diagnostic performance in breast cancer. +other 33440868 hsa-mir-100 Breast Neoplasms The AUC for each DE miRNA, miR-10b, miR-21, miR-96, miR-99a, miR-100, miR-125b-1, miR-125b-2, miR-139, miR-141, miR-145, miR-182, miR-183, miR-195, miR-200a, miR-337, miR-429, and let-7c, exceeded 0.9, indicating excellent diagnostic performance in breast cancer. +other 33440868 hsa-mir-99a Breast Neoplasms The AUC for each DE miRNA, miR-10b, miR-21, miR-96, miR-99a, miR-100, miR-125b-1, miR-125b-2, miR-139, miR-141, miR-145, miR-182, miR-183, miR-195, miR-200a, miR-337, miR-429, and let-7c, exceeded 0.9, indicating excellent diagnostic performance in breast cancer. +other 33440868 hsa-mir-96 Breast Neoplasms The AUC for each DE miRNA, miR-10b, miR-21, miR-96, miR-99a, miR-100, miR-125b-1, miR-125b-2, miR-139, miR-141, miR-145, miR-182, miR-183, miR-195, miR-200a, miR-337, miR-429, and let-7c, exceeded 0.9, indicating excellent diagnostic performance in breast cancer. +other 33440868 hsa-mir-10b Breast Neoplasms The AUC for each DE miRNA, miR-10b, miR-21, miR-96, miR-99a, miR-100, miR-125b-1, miR-125b-2, miR-139, miR-141, miR-145, miR-182, miR-183, miR-195, miR-200a, miR-337, miR-429, and let-7c, exceeded 0.9, indicating excellent diagnostic performance in breast cancer. +other 33440868 hsa-mir-141 Breast Neoplasms The AUC for each DE miRNA, miR-10b, miR-21, miR-96, miR-99a, miR-100, miR-125b-1, miR-125b-2, miR-139, miR-141, miR-145, miR-182, miR-183, miR-195, miR-200a, miR-337, miR-429, and let-7c, exceeded 0.9, indicating excellent diagnostic performance in breast cancer. +other 33440868 hsa-mir-139 Breast Neoplasms The AUC for each DE miRNA, miR-10b, miR-21, miR-96, miR-99a, miR-100, miR-125b-1, miR-125b-2, miR-139, miR-141, miR-145, miR-182, miR-183, miR-195, miR-200a, miR-337, miR-429, and let-7c, exceeded 0.9, indicating excellent diagnostic performance in breast cancer. +other 33440868 hsa-mir-195 Breast Neoplasms The AUC for each DE miRNA, miR-10b, miR-21, miR-96, miR-99a, miR-100, miR-125b-1, miR-125b-2, miR-139, miR-141, miR-145, miR-182, miR-183, miR-195, miR-200a, miR-337, miR-429, and let-7c, exceeded 0.9, indicating excellent diagnostic performance in breast cancer. +other 33440868 hsa-mir-337 Breast Neoplasms The AUC for each DE miRNA, miR-10b, miR-21, miR-96, miR-99a, miR-100, miR-125b-1, miR-125b-2, miR-139, miR-141, miR-145, miR-182, miR-183, miR-195, miR-200a, miR-337, miR-429, and let-7c, exceeded 0.9, indicating excellent diagnostic performance in breast cancer. +other 33440868 hsa-mir-125b-2 Breast Neoplasms The AUC for each DE miRNA, miR-10b, miR-21, miR-96, miR-99a, miR-100, miR-125b-1, miR-125b-2, miR-139, miR-141, miR-145, miR-182, miR-183, miR-195, miR-200a, miR-337, miR-429, and let-7c, exceeded 0.9, indicating excellent diagnostic performance in breast cancer. +other 33440868 hsa-mir-200a Breast Neoplasms The AUC for each DE miRNA, miR-10b, miR-21, miR-96, miR-99a, miR-100, miR-125b-1, miR-125b-2, miR-139, miR-141, miR-145, miR-182, miR-183, miR-195, miR-200a, miR-337, miR-429, and let-7c, exceeded 0.9, indicating excellent diagnostic performance in breast cancer. +other 33440868 hsa-mir-125b-1 Breast Neoplasms The AUC for each DE miRNA, miR-10b, miR-21, miR-96, miR-99a, miR-100, miR-125b-1, miR-125b-2, miR-139, miR-141, miR-145, miR-182, miR-183, miR-195, miR-200a, miR-337, miR-429, and let-7c, exceeded 0.9, indicating excellent diagnostic performance in breast cancer. +other 33440868 hsa-mir-21 Breast Neoplasms The AUC for each DE miRNA, miR-10b, miR-21, miR-96, miR-99a, miR-100, miR-125b-1, miR-125b-2, miR-139, miR-141, miR-145, miR-182, miR-183, miR-195, miR-200a, miR-337, miR-429, and let-7c, exceeded 0.9, indicating excellent diagnostic performance in breast cancer. +other 33440868 hsa-mir-182 Breast Neoplasms The AUC for each DE miRNA, miR-10b, miR-21, miR-96, miR-99a, miR-100, miR-125b-1, miR-125b-2, miR-139, miR-141, miR-145, miR-182, miR-183, miR-195, miR-200a, miR-337, miR-429, and let-7c, exceeded 0.9, indicating excellent diagnostic performance in breast cancer. +other 33440868 hsa-mir-183 Breast Neoplasms The AUC for each DE miRNA, miR-10b, miR-21, miR-96, miR-99a, miR-100, miR-125b-1, miR-125b-2, miR-139, miR-141, miR-145, miR-182, miR-183, miR-195, miR-200a, miR-337, miR-429, and let-7c, exceeded 0.9, indicating excellent diagnostic performance in breast cancer. +other 33440868 hsa-let-7c Breast Neoplasms The AUC for each DE miRNA, miR-10b, miR-21, miR-96, miR-99a, miR-100, miR-125b-1, miR-125b-2, miR-139, miR-141, miR-145, miR-182, miR-183, miR-195, miR-200a, miR-337, miR-429, and let-7c, exceeded 0.9, indicating excellent diagnostic performance in breast cancer. +other 33440868 hsa-mir-145 Breast Neoplasms The AUC for each DE miRNA, miR-10b, miR-21, miR-96, miR-99a, miR-100, miR-125b-1, miR-125b-2, miR-139, miR-141, miR-145, miR-182, miR-183, miR-195, miR-200a, miR-337, miR-429, and let-7c, exceeded 0.9, indicating excellent diagnostic performance in breast cancer. +other 33440716 hsa-mir-155 Cardiovascular Diseases 3p) induced upregulation of several microRNAs. +other 33440716 hsa-mir-92a Cardiovascular Diseases 3p) induced upregulation of several microRNAs. +other 33440716 hsa-mir-210 Cardiovascular Diseases 3p) induced upregulation of several microRNAs. +transcription factor target 33440070 hsa-mir-103 Osteoporosis Collectively, our results highlight the critical roles of the miR3p/METTL14/m(6) A signaling axis in osteoblast activity, identifying this axis as a potential target for ameliorating osteoporosis. +genetics_knock down_promote 33439936 hsa-mir-101 Osteosarcoma In conclusion, lncRNA HCP5 knockdown suppressed cell proliferation, migration, and invasion, and induced apoptosis through depleting the expression of EPHA7 by binding to miR-101, providing a potential therapeutic strategy of HCP5 in OS. +other 33439933 hsa-mir-1273a Colonic Neoplasms Thus, we suggest that methods to promote miR-1273a expression may serve as novel therapeutic strategies in colon cancer. +circRNA target 33439739 hsa-mir-542 Stomach Neoplasms 3p, thus promoting GC progression, indicating that hsa_circ_0023409 may serve as a potential target for treatment of GC and prognosis of GC patients. +tissue_expression_ns 33439455 hsa-mir-294 Selenium Deficiency Our experimental results show that Se deficiency can reduce the expression of miR-294 and increase both the expression of iNOS and the nitric oxide (NO) content (P < 0.01). In summary, we believe that Se deficiency can lead to abnormal expression of miR-294 and HSPs; moreover, the mitochondrial apoptosis pathway is activated, which significantly enhances apoptosis of cerebellar cells in Se-deficient pigs. +circRNA target 33439448 hsa-mir-135a Angelman Syndrome ASV protected HUVECs against ox-LDL-induced injury through targeting circ_0000231/miR-135a-5p/CLIC4 axis. Targeting circ_0000231/miR-135a-5p/CLIC4 axis might provide a novel insight to develop effective strategy for AS treatment. +circRNA target 33439448 hsa-mir-135a Atherosclerosis ASV protected HUVECs against ox-LDL-induced injury through targeting circ_0000231/miR-135a-5p/CLIC4 axis. Targeting circ_0000231/miR-135a-5p/CLIC4 axis might provide a novel insight to develop effective strategy for AS treatment. +lncRNA target 33439430 hsa-mir-24 Spinal Cord Injuries 3p regulated inflammation of highly aggressively proliferating immortalized (HAPI) cells by targeting MK2.In our study, we clarified that miR +genetics_knock down_promote 33439397 hsa-mir-873 Carcinoma, Hepatocellular 5p overexpression or DLC1 knockdown attenuated the suppressive effects of circZKSCAN1 on HCC tumor growth in vitro. +other 33439343 hsa-mir-181b Carcinoma, Squamous Cell OBJECTIVES This study aimed to analyze the expression of miR-181b, miR-21, miR-31, and miR-345 in actinic cheilitis with and without epithelial dysplasia and lower lip squamous cell carcinomas, and to verify if the deregulated expression of these miRNAs would be indicative of malignant transformation. +other 33439343 hsa-mir-181b Lip, Hamartomatous CONCLUSIONS The upregulation of miR-181b, miR-31, and miR-345 expression in actinic cheilitis without epithelial dysplasia and the decrease in the expression of these miRNAs in actinic cheilitis with epithelial dysplasia and in lower lip cancer are potential biomarkers of malignant progression. +other 33439343 hsa-mir-181b Carcinoma in Situ CONCLUSIONS The upregulation of miR-181b, miR-31, and miR-345 expression in actinic cheilitis without epithelial dysplasia and the decrease in the expression of these miRNAs in actinic cheilitis with epithelial dysplasia and in lower lip cancer are potential biomarkers of malignant progression. +other 33439343 hsa-mir-181b Actinic cheilitis CONCLUSIONS The upregulation of miR-181b, miR-31, and miR-345 expression in actinic cheilitis without epithelial dysplasia and the decrease in the expression of these miRNAs in actinic cheilitis with epithelial dysplasia and in lower lip cancer are potential biomarkers of malignant progression. +other 33439343 hsa-mir-345 Squamous Cell Carcinoma of Head and Neck OBJECTIVES This study aimed to analyze the expression of miR-181b, miR-21, miR-31, and miR-345 in actinic cheilitis with and without epithelial dysplasia and lower lip squamous cell carcinomas, and to verify if the deregulated expression of these miRNAs would be indicative of malignant transformation. +other 33439343 hsa-mir-181b Lip Neoplasms CONCLUSIONS The upregulation of miR-181b, miR-31, and miR-345 expression in actinic cheilitis without epithelial dysplasia and the decrease in the expression of these miRNAs in actinic cheilitis with epithelial dysplasia and in lower lip cancer are potential biomarkers of malignant progression. +other 33439343 hsa-mir-345 Actinic cheilitis CONCLUSIONS The upregulation of miR-181b, miR-31, and miR-345 expression in actinic cheilitis without epithelial dysplasia and the decrease in the expression of these miRNAs in actinic cheilitis with epithelial dysplasia and in lower lip cancer are potential biomarkers of malignant progression. +other 33439343 hsa-mir-345 Lip, Hamartomatous CONCLUSIONS The upregulation of miR-181b, miR-31, and miR-345 expression in actinic cheilitis without epithelial dysplasia and the decrease in the expression of these miRNAs in actinic cheilitis with epithelial dysplasia and in lower lip cancer are potential biomarkers of malignant progression. +other 33439343 hsa-mir-345 Lip Neoplasms CONCLUSIONS The upregulation of miR-181b, miR-31, and miR-345 expression in actinic cheilitis without epithelial dysplasia and the decrease in the expression of these miRNAs in actinic cheilitis with epithelial dysplasia and in lower lip cancer are potential biomarkers of malignant progression. +other 33439343 hsa-mir-21 Lip, Hamartomatous Hierarchical clustering analysis showed a tendency for a downregulation of miR-181b, miR-21, miR-31, and miR-345 in most patients with lower lip cancers. +other 33439343 hsa-mir-21 Carcinoma, Squamous Cell OBJECTIVES This study aimed to analyze the expression of miR-181b, miR-21, miR-31, and miR-345 in actinic cheilitis with and without epithelial dysplasia and lower lip squamous cell carcinomas, and to verify if the deregulated expression of these miRNAs would be indicative of malignant transformation. +other 33439343 hsa-mir-21 Carcinoma in Situ OBJECTIVES This study aimed to analyze the expression of miR-181b, miR-21, miR-31, and miR-345 in actinic cheilitis with and without epithelial dysplasia and lower lip squamous cell carcinomas, and to verify if the deregulated expression of these miRNAs would be indicative of malignant transformation. +other 33439343 hsa-mir-345 Carcinoma, Squamous Cell OBJECTIVES This study aimed to analyze the expression of miR-181b, miR-21, miR-31, and miR-345 in actinic cheilitis with and without epithelial dysplasia and lower lip squamous cell carcinomas, and to verify if the deregulated expression of these miRNAs would be indicative of malignant transformation. +other 33439343 hsa-mir-21 Actinic cheilitis OBJECTIVES This study aimed to analyze the expression of miR-181b, miR-21, miR-31, and miR-345 in actinic cheilitis with and without epithelial dysplasia and lower lip squamous cell carcinomas, and to verify if the deregulated expression of these miRNAs would be indicative of malignant transformation. There were no differences in miR-21 expression between actinic cheilitis and lower lip cancer. +other 33439343 hsa-mir-21 Lip Neoplasms There were no differences in miR-21 expression between actinic cheilitis and lower lip cancer. Hierarchical clustering analysis showed a tendency for a downregulation of miR-181b, miR-21, miR-31, and miR-345 in most patients with lower lip cancers. +other 33439343 hsa-mir-345 Carcinoma in Situ CONCLUSIONS The upregulation of miR-181b, miR-31, and miR-345 expression in actinic cheilitis without epithelial dysplasia and the decrease in the expression of these miRNAs in actinic cheilitis with epithelial dysplasia and in lower lip cancer are potential biomarkers of malignant progression. +other 33439343 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck OBJECTIVES This study aimed to analyze the expression of miR-181b, miR-21, miR-31, and miR-345 in actinic cheilitis with and without epithelial dysplasia and lower lip squamous cell carcinomas, and to verify if the deregulated expression of these miRNAs would be indicative of malignant transformation. +other 33439343 hsa-mir-181b Squamous Cell Carcinoma of Head and Neck OBJECTIVES This study aimed to analyze the expression of miR-181b, miR-21, miR-31, and miR-345 in actinic cheilitis with and without epithelial dysplasia and lower lip squamous cell carcinomas, and to verify if the deregulated expression of these miRNAs would be indicative of malignant transformation. +other 33439343 hsa-mir-1 Actinic cheilitis CONCLUSIONS The upregulation of miR-181b, miR-31, and miR-345 expression in actinic cheilitis without epithelial dysplasia and the decrease in the expression of these miRNAs in actinic cheilitis with epithelial dysplasia and in lower lip cancer are potential biomarkers of malignant progression. +other 33439343 hsa-mir-1 Lip Neoplasms CONCLUSIONS The upregulation of miR-181b, miR-31, and miR-345 expression in actinic cheilitis without epithelial dysplasia and the decrease in the expression of these miRNAs in actinic cheilitis with epithelial dysplasia and in lower lip cancer are potential biomarkers of malignant progression. +other 33439343 hsa-mir-1 Squamous Cell Carcinoma of Head and Neck OBJECTIVES This study aimed to analyze the expression of miR-181b, miR-21, miR-31, and miR-345 in actinic cheilitis with and without epithelial dysplasia and lower lip squamous cell carcinomas, and to verify if the deregulated expression of these miRNAs would be indicative of malignant transformation. +other 33439343 hsa-mir-1 Lip, Hamartomatous CONCLUSIONS The upregulation of miR-181b, miR-31, and miR-345 expression in actinic cheilitis without epithelial dysplasia and the decrease in the expression of these miRNAs in actinic cheilitis with epithelial dysplasia and in lower lip cancer are potential biomarkers of malignant progression. +other 33439343 hsa-mir-1 Carcinoma, Squamous Cell OBJECTIVES This study aimed to analyze the expression of miR-181b, miR-21, miR-31, and miR-345 in actinic cheilitis with and without epithelial dysplasia and lower lip squamous cell carcinomas, and to verify if the deregulated expression of these miRNAs would be indicative of malignant transformation. +other 33439343 hsa-mir-1 Carcinoma in Situ CONCLUSIONS The upregulation of miR-181b, miR-31, and miR-345 expression in actinic cheilitis without epithelial dysplasia and the decrease in the expression of these miRNAs in actinic cheilitis with epithelial dysplasia and in lower lip cancer are potential biomarkers of malignant progression. +other 33438262 hsa-mir-200 Celiac Disease Since the family of miR-200 has previously been suggested to contribute to the distinct physiological function of sperm maturation in epididymis of adult rat, we speculate that the downregulation of miR-200a in CY caput epididymis may play an important role of sperm maturation in the epididymis of CY. +other 33438262 hsa-mir-200a Celiac Disease Since the family of miR-200 has previously been suggested to contribute to the distinct physiological function of sperm maturation in epididymis of adult rat, we speculate that the downregulation of miR-200a in CY caput epididymis may play an important role of sperm maturation in the epididymis of CY. +other 33438067 hsa-mir-383 Spinal Cord Injuries The results showed that lncRNA CASC9 was downregulated and miR5p was upregulated in SCI rats and LPS-induced PC12 cells. +other 33437770 hsa-mir-212 Pulmonary Arterial Hypertension CONCLUSIONS: These results suggest that the reduction of the expression of MIR3p may be a biomarker for PAH patients with right heart dysfunction. +other 33437770 hsa-mir-212 Heart Failure CONCLUSIONS: These results suggest that the reduction of the expression of MIR3p may be a biomarker for PAH patients with right heart dysfunction. +other 33437631 hsa-mir-583 Intervertebral Disc Degeneration CONCLUSION: Findings of this study indicated that circ-FAM169A-miR-583 pathway may play a significant role in the regulation of IDD, which will provide novel diagnostic biomarkers and develop effective treatment strategy of IDD diseases. +other 33437394 hsa-mir-938 Precursor Cell Lymphoblastic Leukemia-Lymphoma A protective effect against the development of ALL was also observed in the carriers of the wild homozygous rs2505901 genotype in the MIR938 gene. +lncRNA target 33437374 hsa-mir-24 Instent Restenosis 3p which is elevated in CHD, and evidently upregulates BCL2-like 11 (BCL2L11) which is suppressed in CHD, as well as affects the activation of peroxisome proliferator-activated receptors (PPARs)-Peroxisome proliferator activated receptor-gamma co-activator-1alpha (PGC-1alpha) pathway of nuclear receptor transcription factors. +target gene 33437368 hsa-mir-335 Colonic Neoplasms MicroRNA-335 targets the MEK/ERK pathway to regulate the proliferation and metastasis of colon cancer. +other 33437356 hsa-mir-17 Arthritis, Rheumatoid In conclusion, lncRNA LOC100912373 may upregulate the expression of PDK1 by sponging miR5p, accelerating the phosphorylation of AKT and inducing the proliferation of FLSs, thus promoting the occurrence and development of RA. +lncRNA target 33437196 hsa-mir-34c Liver Cirrhosis Our results indicate that miR-34c plays an essential role in liver fibrosis by targeting ACSL1 closely associated with lipid droplets, and it might be used as a potential therapeutic target. +other 33436962 hsa-mir-155 Inflammation Interestingly, upon testing CUR, RES, and SFN against LPS/IFN-gamma-mediated inflammation, only SFN was able to significantly reverse the LPS/IFN-gamma-mediated induction of iNOS, TNF-alpha and IL-6 and attenuate miR-146a and miR-155 levels. +other 33436962 hsa-mir-146a Inflammation Interestingly, upon testing CUR, RES, and SFN against LPS/IFN-gamma-mediated inflammation, only SFN was able to significantly reverse the LPS/IFN-gamma-mediated induction of iNOS, TNF-alpha and IL-6 and attenuate miR-146a and miR-155 levels. +other 33436947 hsa-mir-197 Familial Mediterranean Fever This study may contribute to understand the role of miR3p in autoinflammation process. +other 33436941 hsa-mir-338 Squamous Cell Carcinoma of Head and Neck 3P/E2F1 axis are involved in the regulation of ESCC growth. +epigenetics 33436720 hsa-mir-379 Sarcoma Differentially methylated regions and genes were detected, not been previously implicated in sarcoma progression, including at PTPRN2 and DAXX in LMS, WT1-AS and TNXB in SS, VENTX and NTRK3 in pleomorphic RMS and MEST and the C14MC / miR-379/miR-656 in MFS. +epigenetics 33436720 hsa-mir-656 Sarcoma Differentially methylated regions and genes were detected, not been previously implicated in sarcoma progression, including at PTPRN2 and DAXX in LMS, WT1-AS and TNXB in SS, VENTX and NTRK3 in pleomorphic RMS and MEST and the C14MC / miR-379/miR-656 in MFS. +other 33436554 hsa-mir-146a Lung Injury These data indicate that the endogenous increase in microRNA-146a during mechanical ventilation is a compensatory response that partially limits injury and that nanoparticle delivery of miR-146a is an effective strategy for mitigating lung injury during mechanical ventilation. +other 33436554 hsa-mir-146a Lung Diseases These data indicate that the endogenous increase in microRNA-146a during mechanical ventilation is a compensatory response that partially limits injury and that nanoparticle delivery of miR-146a is an effective strategy for mitigating lung injury during mechanical ventilation. +genetics_overexpression_promote 33436545 hsa-mir-424 Cholangiocarcinoma Moreover, silencing BCL9L or miR5p overexpression suppressed gemcitabine resistance, EMT, stemness and Wnt/beta-Catenin activation in resistant CCA cells. +other 33436530 hsa-mir-133b Heart Arrest Our study demonstrates that NSCs promotes the release of miR-133b from BMSCs-derived EVs to promote neuronal cell survival, representing a potential therapeutic strategy for the treatment of CA-induced brain damage. +other 33436040 hsa-mir-483 Lupus Nephritis 3p in LN. +circulation_biomarker_prognosis_ns 33436002 hsa-mir-128-2 Breast Neoplasms RESULTS: We identified a GI-derived three miRNA signature (MIR421, MIR128-1 and MIR128-2) in the serum extracellular vesicles of BC patients, which was significantly associated with poor prognosis in all the cohorts tested and remained as an independent prognostic factor using multivariate analyses. +circulation_biomarker_prognosis_ns 33436002 hsa-mir-128-1 Breast Neoplasms RESULTS: We identified a GI-derived three miRNA signature (MIR421, MIR128-1 and MIR128-2) in the serum extracellular vesicles of BC patients, which was significantly associated with poor prognosis in all the cohorts tested and remained as an independent prognostic factor using multivariate analyses. +circulation_biomarker_prognosis_ns 33436002 hsa-mir-421 Breast Neoplasms RESULTS: We identified a GI-derived three miRNA signature (MIR421, MIR128-1 and MIR128-2) in the serum extracellular vesicles of BC patients, which was significantly associated with poor prognosis in all the cohorts tested and remained as an independent prognostic factor using multivariate analyses. +genetics_knock down_promote 33435987 hsa-mir-494 Osteosarcoma CONCLUSION: Knockdown of circ_0081001 enhanced MTX sensitivity of OS cells through downregulating TGM2 by sponging miR +genetics_knock down_promote 33435956 hsa-mir-663a Osteoarthritis In addition, miR-663a inhibition increased the proliferation and reduced the apoptosis of OA cells, while FRK knockdown reversed the effect of miR-663a inhibition on the proliferation and apoptosis of OA cells. +other 33435900 hsa-mir-106b Diabetic Nephropathies CONCLUSIONS: We speculated that the RP11-363E7.4/TTN-AS1/HOTAIRM1-hsa-miR-106b-5p-PTGE and LINC00960-hsa-miR3p-MMP-2 networks were associated with diabetic renal injury. +other 33435900 hsa-mir-1237 Diabetic Nephropathies CONCLUSIONS: We speculated that the RP11-363E7.4/TTN-AS1/HOTAIRM1-hsa-miR-106b-5p-PTGE and LINC00960-hsa-miR3p-MMP-2 networks were associated with diabetic renal injury. +lncRNA target 33435858 hsa-mir-34a Inflammation Conclusion: inhibition of LINC00665 improved cell viability, suppressed apoptosis and inflammation in LPS-induced PC12 cells, and the NF-kappaB1/LINC00665/miR-34a-5ploop might be a useful therapeutic target in SCI treatment. +lncRNA target 33435858 hsa-mir-34a Spinal Cord Injuries Conclusion: inhibition of LINC00665 improved cell viability, suppressed apoptosis and inflammation in LPS-induced PC12 cells, and the NF-kappaB1/LINC00665/miR-34a-5ploop might be a useful therapeutic target in SCI treatment. +circulation_biomarker_prognosis_ns 33435769 hsa-mir-615 Carcinoma, Hepatocellular MiR-3615 expression levels in HCC patients were negatively correlated with overall survival time and positively correlated with high TNM stage, serum Ki-67 expression level, and serum alpha-fetoprotein level. +genetics_overexpression_suppress 33434946 hsa-mir-342 Bronchopulmonary Dysplasia T2AEC-specific miR-342 transgenic overexpression, as well as miR +lncRNA target 33434756 hsa-mir-146a Colitis Vilda has markedly inhibited the expression of lncRNA IFNG-AS1 and miR-146a, as well as PI3K/Akt/NFkappaB pathway, while activated CREB and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways, and this was reflected in alleviated oxidative stress, inflammation and apoptosis. +other 33434689 hsa-mir-494 Liver Cirrhosis 3p was reduced in AH liver tissues, and it decreased the levels of alpha-SMA and fibrosis-related proteins. +other 33434537 hsa-mir-34c Osteoporosis In summary, PDE can cause H-type vessel dysplasia and high susceptibility to osteoporosis in female offspring, and its mechanism is related to the low-activity programming of the PDGFRbeta/FAK pathway induced by GR/C/EBPalpha/miR-34c signalling activation. +lncRNA target 33434322 hsa-mir-144 Fatty Liver CONCLUSIONS MCs promote WD-induced biliary and liver damage and may promote microvesicular steatosis development during NAFLD progression to NASH through miR +lncRNA target 33434322 hsa-mir-144 Non-alcoholic Fatty Liver Disease CONCLUSIONS MCs promote WD-induced biliary and liver damage and may promote microvesicular steatosis development during NAFLD progression to NASH through miR +lncRNA target 33434305 hsa-mir-15 Osteoporosis Taken altogether, miR-15b inhibits osteoblast differentiation and autophagy to aggravate osteoporosis by targeting USP7 to regulate KDM6B expression. +lncRNA target 33434305 hsa-mir-15b Osteoporosis Taken altogether, miR-15b inhibits osteoblast differentiation and autophagy to aggravate osteoporosis by targeting USP7 to regulate KDM6B expression. +genetics_overexpression_suppress 33434085 hsa-mir-187 esophagus adenocarcinoma METHODS: The effect of miR-187 overexpression on downstream PI3K signalling was evaluated in OAC cell lines by qPCR and Western blotting. +circulation_biomarker_diagnosis_up 33434077 hsa-mir-16 Gastrointestinal Neoplasms Moreover, the subgroup analyses have been performed for miR-21 based on sample types (serum/plasma), normalized genes (U6, miR-16, and miR-39), and ethnicity.Results: The pooled sensitivity 0.722 (95% CI: 0.70-0.74), specificity 0.820 (95% CI: 0.801-0.838), PLR 4.375 (95% CI: 3.226-5.933), NLR 0.308 (95% CI: 0.239-0.398), DOR 16.06 (95% CI: 9.732-26.53) as well as AUC 0.86, and Q* index 0.79 represented the high-grade diagnostic precision of miR-21 in identifying GICs (ESCC, GC, CRC, HCC, and PC).Conclusion: This meta-analysis demonstrated that circulating miR-21 levels can be used to monitor the digestive system carcinomas. +circulation_biomarker_diagnosis_up 33434077 hsa-mir-21 Gastrointestinal Neoplasms Moreover, the subgroup analyses have been performed for miR-21 based on sample types (serum/plasma), normalized genes (U6, miR-16, and miR-39), and ethnicity.Results: The pooled sensitivity 0.722 (95% CI: 0.70-0.74), specificity 0.820 (95% CI: 0.801-0.838), PLR 4.375 (95% CI: 3.226-5.933), NLR 0.308 (95% CI: 0.239-0.398), DOR 16.06 (95% CI: 9.732-26.53) as well as AUC 0.86, and Q* index 0.79 represented the high-grade diagnostic precision of miR-21 in identifying GICs (ESCC, GC, CRC, HCC, and PC).Conclusion: This meta-analysis demonstrated that circulating miR-21 levels can be used to monitor the digestive system carcinomas. +circulation_biomarker_diagnosis_up 33434077 hsa-mir-9 Gastrointestinal Neoplasms Moreover, the subgroup analyses have been performed for miR-21 based on sample types (serum/plasma), normalized genes (U6, miR-16, and miR-39), and ethnicity.Results: The pooled sensitivity 0.722 (95% CI: 0.70-0.74), specificity 0.820 (95% CI: 0.801-0.838), PLR 4.375 (95% CI: 3.226-5.933), NLR 0.308 (95% CI: 0.239-0.398), DOR 16.06 (95% CI: 9.732-26.53) as well as AUC 0.86, and Q* index 0.79 represented the high-grade diagnostic precision of miR-21 in identifying GICs (ESCC, GC, CRC, HCC, and PC).Conclusion: This meta-analysis demonstrated that circulating miR-21 levels can be used to monitor the digestive system carcinomas. +lncRNA target 33433806 hsa-mir-421 Carcinoma, Hepatocellular CONCLUSIONS: Lidocaine represses hepatocellular carcinoma cell proliferation, migration, and invasion and promotes apoptosis via regulating circ_ITCH/miR-421/CPEB3 axis, indicating a new insight into the mechanism of lidocaine in hepatocellular carcinoma. +genetics_knock down_promote 33433801 hsa-mir-375 Carcinoma, Hepatocellular CONCLUSION: Knockdown of circZFR suppressed the progression of HCC by upregulating miR-375 and downregulating HMGA2, providing new insight into the pathogenesis of HCC. +lncRNA target 33433751 hsa-mir-21 Acute Kidney Injury In conclusion, exogenous H(2)S and inhibition of miR-21 rescued the old kidney dysfunction due to IRI by increasing H(2)S levels, reduction of macrophage-mediated injury, and promoting reparative process suggesting a viable approach for aged patients sustaining AKI. +circulation_biomarker_diagnosis_ns 33433717 hsa-mir-1231 Carcinoma, Basal Cell Circ_0005795 located in cytoplasm, which exerted its tumor-promoting effect through targeting and sponging miR-1231 in BCC cells. +genetics_knock down_promote 33433641 hsa-mir-199 Osteoarthritis, Knee 3p up-regulation or down-regulation of DNMT3A induces chondrocyte proliferation and inhibits apoptosis in KOA, which may widen our eyes to treat patients with KOA. +other 33433409 hsa-mir-216b Stomach Neoplasms CONCLUSION: Our preliminary study showed that the expression of microRNA-216b in gastric cancer tissues with peritoneal metastasis was significantly lower than that in patients without peritoneal metastasis, while the expression of PARK7 was the opposite. +other 33432840 hsa-mir-486 Fibrosis 3p may represent a potential risk factor for the development or progression of liver fibrosis/cirrhosis by means of a reduced UGT1A-mediated detoxification activity. +other 33432705 hsa-mir-122 Mycobacterium Infections, Nontuberculous CONCLUSION In patients treated with anti-TB therapy, miR-122 and K18 correlated with ALT and increased with DILI. +lncRNA target 33432525 hsa-mir-363 Retinoblastoma In conclusion, FEZF1-AS1 elevated growth and inhibited apoptosis by regulating miR3p/PAX6 in retinoblastoma, which provide a new target for retinoblastoma treatment. +lncRNA target 33432363 hsa-mir-18a Esophageal Neoplasms In conclusion, data from the present study unveil a potential ceRNA regulatory pathway, in which PART1 affects SOX6 expression level by sponging miR18a5p, to ultimately suppress ESCC development and progression. +lncRNA target 33431945 hsa-mir-498 Carcinoma, Hepatocellular Moreover, miR-498 over-expression or NAP1L3 inhibition could abrogate the oncogene role of circGFRA1 in HCC in vivo. +lncRNA target 33431894 hsa-mir-134 Status Epilepticus Previous studies in adult rodents have detected upregulation of microRNA-134 after prolonged seizures (status epilepticus) and demonstrated that silencing microRNA-134 using antisense oligonucleotides, termed antagomirs, has potent and long-lasting seizure-suppressive effects. +lncRNA target 33431894 hsa-mir-134 Seizures These studies demonstrate targeting microRNA-134 may have therapeutic applications for the treatment of seizures in children. +circulation_biomarker_diagnosis_up 33431881 hsa-mir-206 Amyotrophic Lateral Sclerosis In particular, we found that miR-206 and miR-151a-5p serum levels were significantly up-regulated at the mild stage of ALS pathology, to decrease in the following moderate and severe stages, whereas the expression levels of miR-133a and miR-199a-5p remained low throughout the course of the disease, showing a diagnostic significance in moderate and severe stages for miR-133a and in mild and terminal ones for miR-199a-5p. +circulation_biomarker_diagnosis_up 33431881 hsa-mir-133a Amyotrophic Lateral Sclerosis In particular, we found that miR-206 and miR-151a-5p serum levels were significantly up-regulated at the mild stage of ALS pathology, to decrease in the following moderate and severe stages, whereas the expression levels of miR-133a and miR-199a-5p remained low throughout the course of the disease, showing a diagnostic significance in moderate and severe stages for miR-133a and in mild and terminal ones for miR-199a-5p. +circulation_biomarker_diagnosis_up 33431881 hsa-mir-199a Amyotrophic Lateral Sclerosis In particular, we found that miR-206 and miR-151a-5p serum levels were significantly up-regulated at the mild stage of ALS pathology, to decrease in the following moderate and severe stages, whereas the expression levels of miR-133a and miR-199a-5p remained low throughout the course of the disease, showing a diagnostic significance in moderate and severe stages for miR-133a and in mild and terminal ones for miR-199a-5p. +circulation_biomarker_diagnosis_up 33431881 hsa-mir-151a Amyotrophic Lateral Sclerosis In particular, we found that miR-206 and miR-151a-5p serum levels were significantly up-regulated at the mild stage of ALS pathology, to decrease in the following moderate and severe stages, whereas the expression levels of miR-133a and miR-199a-5p remained low throughout the course of the disease, showing a diagnostic significance in moderate and severe stages for miR-133a and in mild and terminal ones for miR-199a-5p. +epigenetics 33431791 hsa-mir-181b-1 Osteosarcoma Whereas ALKBH5 silence enhanced m(6)A methylations of pre-miR-181b-1 and YAP-mRNA exerting oncogenic functions in osteosarcoma. +target gene 33431790 hsa-mir-483 Breast Neoplasms Metformin exhibits antiproliferation activity in breast cancer via miR-483-3p/METTL3/m(6)A/p21 pathway. +other 33431517 hsa-mir-378f Cerebral Small Vessel Diseases The levels of microRNA-378f were significantly increased among the patients with osteoporosis and maximal total SVD score and positively correlated with parathyroid hormone and osteocalcin. +other 33430976 hsa-mir-145 Mixed Connective Tissue Disease CONCLUSIONS: The results of our case-control study indicate the possible significance of miR-146a and miR-143/145 in the susceptibility and clinical picture of MCTD. +other 33430976 hsa-mir-143 Mixed Connective Tissue Disease CONCLUSIONS: The results of our case-control study indicate the possible significance of miR-146a and miR-143/145 in the susceptibility and clinical picture of MCTD. +other 33430976 hsa-mir-146a Mixed Connective Tissue Disease miR-146a rs2910164 C/T was associated with scleroderma and lymphadenopathy. +other 33430976 hsa-mir-146 Mixed Connective Tissue Disease miR-146a rs2910164 C/T was associated with scleroderma and lymphadenopathy. +other 33430976 hsa-mir-155 Mixed Connective Tissue Disease miRNAs such as miR-146, miR-155, and miR-143 emerged as key regulators of the immune system, known to be involved in the development of autoimmune diseases and cancers. +lncRNA target 33430962 hsa-mir-20a Lung Diseases, Interstitial CONCLUSION: miR-320a, together with its target genes, TGFBR2 and IGF1R, constituted a complex regulatory network, and played an important role in the fibrotic process of SSc-ILD. +lncRNA target 33430962 hsa-mir-20a Scleroderma, Systemic CONCLUSION: miR-320a, together with its target genes, TGFBR2 and IGF1R, constituted a complex regulatory network, and played an important role in the fibrotic process of SSc-ILD. +other 33430952 hsa-mir-125a Leukemia, Lymphocytic, Chronic, B-Cell Finally, miR-223 can be used as a prognostic factor in CLL patients; miR-125a may be useful for evaluating the therapeutic approaches based on the inverse link with BCl-2. +other 33430952 hsa-mir-223 Leukemia, Lymphocytic, Chronic, B-Cell Finally, miR-223 can be used as a prognostic factor in CLL patients; miR-125a may be useful for evaluating the therapeutic approaches based on the inverse link with BCl-2. +genetics_knock down_promote 33430926 hsa-mir-24 Stomach Neoplasms 5p overexpression predicts poor prognosis in GCa patients, and the reduction of miR +genetics_overexpression_promote 33430878 hsa-mir-758 Melanoma Moreover, overexpression of TCEAL7 abolished miR +lncRNA target 33430870 hsa-mir-885 Glioblastoma CONCLUSION: Overall, HOXA-AS2 promoted the tumorigenesis of glioblastoma by targeting and regulating miR +genetics_knock down_suppress 33430857 hsa-mir-107 Osteoarthritis, Knee This study aimed to investigate whether miR-107 could regulate KOA through pyroptosis to affect collagen protein secreted by chondrocytes through IL-1beta. CONCLUSIONS: miR-107 can protect against KOA by downregulating caspase-1 to decrease pyroptosis, thereby promoting collagen protein secreted by chondrocytes by down-regulating IL-1beta. +transcription factor target 33430801 hsa-mir-486 Urinary Bladder Neoplasms CONCLUSION: Identification of EHHADH as a target of miRNA +other 33430468 hsa-mir-23b Metabolic Diseases Studies examining the roles of miR-23b, miR-27b, and miR1 have demonstrated their multifaceted functions in variable metabolic disorders. +other 33430468 hsa-mir-24-1 Metabolic Diseases Studies examining the roles of miR-23b, miR-27b, and miR1 have demonstrated their multifaceted functions in variable metabolic disorders. +other 33430468 hsa-mir-27b Metabolic Diseases Studies examining the roles of miR-23b, miR-27b, and miR1 have demonstrated their multifaceted functions in variable metabolic disorders. +genetics_GWAS 33430456 hsa-let-7e Stomach Neoplasms For two genetic variants, namely rs8111742 in miR-Let-7e and rs121224 in miR-365b, there were significant differences in PGII levels between genotype groups among patients with gastric cancer (p = 0.02 and p = 0.01, respectively), but not among other study subjects. +genetics_GWAS 33430456 hsa-mir-365b Stomach Neoplasms For two genetic variants, namely rs8111742 in miR-Let-7e and rs121224 in miR-365b, there were significant differences in PGII levels between genotype groups among patients with gastric cancer (p = 0.02 and p = 0.01, respectively), but not among other study subjects. +other 33430425 hsa-mir-20a Brain Neoplasms miR5p, miR-20a obtained a high level of expression in medulloblastomas and ependymomas, while close to the control in the pilocytic astrocytoma samples. +other 33430425 hsa-mir-106a Brain Neoplasms 92: miR-106b-25 and miR-106a-363, in the most common brain tumors of childhood, pilocytic astrocytoma (PA), WHO grade 1; ependymoma (EP), WHO grade 2; and medulloblastoma (MB), WHO grade 4. +other 33430425 hsa-mir-17 Brain Neoplasms miR5p, miR-20a obtained a high level of expression in medulloblastomas and ependymomas, while close to the control in the pilocytic astrocytoma samples. +other 33430391 hsa-mir-378a Retinitis Our findings provide novel insights into an alternative mechanism of action of metformin involving miR-378a-3, which can be used in the future for the development of improved therapeutic strategies against metabolic diseases. +circulation_biomarker_diagnosis_ns 33429910 hsa-mir-26a Hematologic Neoplasms In light of previous reports on miRNA stability in different exosome isolation methods, our data indicated that miR-26a-5p is a bona fide reference miRNA for qRT-PCR normalization to evaluate miRNA abundance from circulating plasma exosomes in studies of hematological malignancies. +other 33429869 hsa-mir-145 nonpapillary renal cell carcinoma Using the coincubation protocol, vesicles were loaded with the anti-tumor miRNA-145, and their effect was evaluated on renal cancer stem cell invasion. +other 33429366 hsa-mir-125b Adenocarcinoma of Lung In conclusion, it was assumed that miR-125b-5p-ACE2-IL6 axis could alter the risk of SARS-CoV-2 infection in lung adenocarcinoma patients. +other 33429366 hsa-mir-125b COVID-19 In conclusion, it was assumed that miR-125b-5p-ACE2-IL6 axis could alter the risk of SARS-CoV-2 infection in lung adenocarcinoma patients. +lncRNA target 33429333 hsa-mir-193a Colorectal Neoplasms These results suggest that miR-193a-5p serves a tumor-suppressive function in CRC and can directly target CXCR4 and decrease its mRNA and protein expression levels. +other 33429194 hsa-mir-21 Acute Kidney Injury Overall, these results implied that hsa_circ_0068,888 shows a protective effect on AKI by sponging miR5p. +other 33428882 hsa-mir-222 Aortic Aneurysm 3p and ADIPOR1 in aortic aneurysm tissues and EPCs were assessed by qRT-PCR or Western blot. +circulation_biomarker_diagnosis_ns 33428882 hsa-mir-222 Aortic Aneurysm, Abdominal RESULTS: AAA exhibited histopathological abnormality, a decreased number of EPCs in the peripheral blood and an increased miR +other 33428882 hsa-mir-222 Aneurysm 3p and ADIPOR1 in aortic aneurysm tissues and EPCs were assessed by qRT-PCR or Western blot. +target gene 33428703 hsa-mir-149 Alzheimer Disease MicroRNA-149 is downregulated in Alzheimer's disease and inhibits β-amyloid accumulation and ameliorates neuronal viability through targeting BACE1. +transcription factor target 33428601 hsa-mir-205 Triple Negative Breast Neoplasms The present study may provide a novel insight for the therapeutic strategies of breast cancer through targeting miR-205/HOXD9/Snail1. +transcription factor target 33428060 hsa-mir-212 Acute Kidney Injury Down-regulation of miR-212 plays a protective role by targeting up-regulation of KLF4 to inhibit renal tissue inflammation, oxidative stress, and apoptosis in rats with AKI, which may be a potential target for clinical treatment of AKI in the future. +circulation_biomarker_prognosis_ns 33426736 hsa-mir-638 Carcinoma, Hepatocellular In patients with HCC, higher serum exosomal miR-638 expression was associated with tumor recurrence. Serum exosomal miR-638 expression holds potential for serving as a significant and independent prognostic marker in HCC. +lncRNA target 33426239 hsa-mir-134 Femur Head Necrosis CircRNA_25487 inhibited bone repair in TIONFH by sponging miR3p to upregulate the expression of p21. +target gene 33426220 hsa-mir-141 Wound Healing LncRNA MALAT1 promotes wound healing via regulating miR-141-3p/ZNF217 axis. +other 33426087 hsa-mir-125a ankylosing spondylitis 1 CONCLUSIONS: Both miRNA-451a and miRNA-125a were found to be of great value as sensitive noninvasive diagnostic, prognostic, and disease burden biomarker of AS patients in Egypt with suggested further studies for future therapeutic implications. +other 33426072 hsa-mir-608 Carcinoma, Non-Small-Cell Lung MiR-608 promotes DOX- (Doxorubicin-) induced apoptosis by negatively regulating TFAP4 expression in NSCLC tissue. +lncRNA target 33426053 hsa-mir-3133 Retinoblastoma mediated JAK2/STAT3 suppression, indicating that the lncRNA RHPN1-AS1 may be a potential therapeutic target for the treatment of RB. +genetics_GWAS 33425925 hsa-mir-182 Retinal Dystrophies To test this hypothesis, we perform mutation screening in the pre-miR-183, -96, -182 in >1000 peripheral blood DNA samples of patients with various forms of IRD. +genetics_GWAS 33425925 hsa-mir-96 Retinal Dystrophies To test this hypothesis, we perform mutation screening in the pre-miR-183, -96, -182 in >1000 peripheral blood DNA samples of patients with various forms of IRD. +genetics_GWAS 33425925 hsa-mir-183 Retinal Dystrophies To test this hypothesis, we perform mutation screening in the pre-miR-183, -96, -182 in >1000 peripheral blood DNA samples of patients with various forms of IRD. +lncRNA target 33425899 hsa-mir-1247 Osteoporosis, Postmenopausal Our results provide evidence that circHmbox1-targeting miR5p is involved in the regulation of bone metabolisms by TNF-alpha in PMOP. +transcription factor target 33425897 hsa-mir-140 Alopecia Therefore, DPC-derived vesicular miR5p represents a therapeutic target for alopecia. +other 33425890 hsa-mir-224 Carcinoma, Non-Small-Cell Lung 3p axis is an essential mechanism by which NSCLC modulates cancer cell stemness. +other 33425879 hsa-mir-885 Intracranial Thrombosis Meanwhile, the regulation of miR3p regulating TF expression may be related to the occurrence of cerebral thrombosis. +genetics_overexpression_promote 33425728 hsa-mir-608 Carcinoma, Renal Cell Subsequent mechanistic research showed that miR-608 is downregulated in ccRCC (P < 0.001), and overexpression of miR-608 inbibited the proliferation of RCC cells. +other 33425718 hsa-mir-361 Pancreatic Neoplasms CircRNA_000864 Upregulates B-cell Translocation Gene 2 Expression and Represses Migration and Invasion in Pancreatic Cancer Cells by Binding to miR-361-3p. +transcription factor target 33425490 hsa-mir-192 Carcinoma, Non-Small-Cell Lung 3p directly targeted cell cycle-promoted factor CCNB1 and suppressed NSCLC cell growth. +other 33425484 hsa-mir-101 Diabetes Mellitus, Type 2 We have identified miRNAs (hsa-let-7b, hsa-miR-101, hsa-miR-130b-3p, hsa-miR-27a, hsa-miR-30a-5p, hsa-miR-375, and hsa-miR-486) that contribute to the prediction of T2DM remission in patients with coronary heart disease. +other 33425484 hsa-mir-27a Diabetes Mellitus, Type 2 We have identified miRNAs (hsa-let-7b, hsa-miR-101, hsa-miR-130b-3p, hsa-miR-27a, hsa-miR-30a-5p, hsa-miR-375, and hsa-miR-486) that contribute to the prediction of T2DM remission in patients with coronary heart disease. +other 33425484 hsa-mir-486 Diabetes Mellitus, Type 2 We have identified miRNAs (hsa-let-7b, hsa-miR-101, hsa-miR-130b-3p, hsa-miR-27a, hsa-miR-30a-5p, hsa-miR-375, and hsa-miR-486) that contribute to the prediction of T2DM remission in patients with coronary heart disease. +other 33425484 hsa-mir-130b Diabetes Mellitus, Type 2 We have identified miRNAs (hsa-let-7b, hsa-miR-101, hsa-miR-130b-3p, hsa-miR-27a, hsa-miR-30a-5p, hsa-miR-375, and hsa-miR-486) that contribute to the prediction of T2DM remission in patients with coronary heart disease. +other 33425484 hsa-mir-130b Coronary Disease We have identified miRNAs (hsa-let-7b, hsa-miR-101, hsa-miR-130b-3p, hsa-miR-27a, hsa-miR-30a-5p, hsa-miR-375, and hsa-miR-486) that contribute to the prediction of T2DM remission in patients with coronary heart disease. +other 33425484 hsa-let-7b Coronary Disease We have identified miRNAs (hsa-let-7b, hsa-miR-101, hsa-miR-130b-3p, hsa-miR-27a, hsa-miR-30a-5p, hsa-miR-375, and hsa-miR-486) that contribute to the prediction of T2DM remission in patients with coronary heart disease. +other 33425484 hsa-mir-375 Coronary Disease We have identified miRNAs (hsa-let-7b, hsa-miR-101, hsa-miR-130b-3p, hsa-miR-27a, hsa-miR-30a-5p, hsa-miR-375, and hsa-miR-486) that contribute to the prediction of T2DM remission in patients with coronary heart disease. +other 33425484 hsa-mir-486 Coronary Disease We have identified miRNAs (hsa-let-7b, hsa-miR-101, hsa-miR-130b-3p, hsa-miR-27a, hsa-miR-30a-5p, hsa-miR-375, and hsa-miR-486) that contribute to the prediction of T2DM remission in patients with coronary heart disease. +other 33425484 hsa-mir-101 Coronary Disease We have identified miRNAs (hsa-let-7b, hsa-miR-101, hsa-miR-130b-3p, hsa-miR-27a, hsa-miR-30a-5p, hsa-miR-375, and hsa-miR-486) that contribute to the prediction of T2DM remission in patients with coronary heart disease. +other 33425484 hsa-mir-375 Diabetes Mellitus, Type 2 We have identified miRNAs (hsa-let-7b, hsa-miR-101, hsa-miR-130b-3p, hsa-miR-27a, hsa-miR-30a-5p, hsa-miR-375, and hsa-miR-486) that contribute to the prediction of T2DM remission in patients with coronary heart disease. +other 33425484 hsa-mir-27a Coronary Disease We have identified miRNAs (hsa-let-7b, hsa-miR-101, hsa-miR-130b-3p, hsa-miR-27a, hsa-miR-30a-5p, hsa-miR-375, and hsa-miR-486) that contribute to the prediction of T2DM remission in patients with coronary heart disease. +other 33425484 hsa-let-7b Diabetes Mellitus, Type 2 We have identified miRNAs (hsa-let-7b, hsa-miR-101, hsa-miR-130b-3p, hsa-miR-27a, hsa-miR-30a-5p, hsa-miR-375, and hsa-miR-486) that contribute to the prediction of T2DM remission in patients with coronary heart disease. +circulation_biomarker_diagnosis_ns 33425479 hsa-mir-92a Sleep Apnea, Obstructive RESULTS: Using two separate cohorts of adults (n=57) and children (n=13), we report a significant increase in the serum level of miR-92a in patients with severe OSA (p=0.021) and further demonstrate a significant correlation (Spearman rank correlation 0.308, p=0.010) with serum miR-92a levels and the apnea hypopnea index (AHI), a primary measure of OSA severity. +lncRNA target 33425108 hsa-mir-99b Carcinoma, Renal Cell CONCLUSION: The low expression of miR-99b and miR-99b* contributes to ccRCC development and miR-99b acts as an onco-suppressor by suppressing IGF1R and mTOR expression to down-regulate IGF1R/AKT/mTOR signaling. +target gene 33425100 hsa-mir-502 Urinary Bladder Neoplasms Cyclic RNA Circ_0000735 sponges miR-502-5p to promote bladder cancer cell proliferation and invasion and inhibit apoptosis. +other 33425099 hsa-mir-577 Uterine Cervical Neoplasms CXCL5 contributes to the tumorigenicity of cervical cancer and is post-transcriptionally regulated by miR-577. +genetics_knock down_promote 33425098 hsa-mir-218 Glioma The targeted relationship between miR-218 and PDE7A was validated: Overexpression of miR-218 was able to suppress the proliferation and invasion of glioma cells and restrain apoptosis compared to the miR-NC group (all P<0.05). +other 33424970 hsa-let-7c Pancreatic Neoplasms Genomic Profiling and Functional Analysis of let-7c miRNA-mRNA Interactions Identify SOX13 to Be Involved in Invasion and Progression of Pancreatic Cancer. +lncRNA target 33424579 hsa-mir-574 Alzheimer Disease 5p might be a potential microRNA target for hsa_circ_0003391. +genetics_overexpression_promote 33423149 hsa-mir-1225 Breast Neoplasms The overexpression of miR-1225 in breast cancer indicates a poor prognosis of patients and promotes the progression of breast cancer by targeting JAK1. +other 33422804 hsa-mir-29a Squamous Cell Carcinoma of Head and Neck The best fitting model (AUC = 0.92) for HPV status included age, smoking, and miRNAs: miR-15b, miR-20b, miR-29a, miR-29c, miR-142, miR-146a and miR-205. +other 33422804 hsa-mir-205 Squamous Cell Carcinoma of Head and Neck The best fitting model (AUC = 0.92) for HPV status included age, smoking, and miRNAs: miR-15b, miR-20b, miR-29a, miR-29c, miR-142, miR-146a and miR-205. +other 33422804 hsa-mir-142 Squamous Cell Carcinoma of Head and Neck The best fitting model (AUC = 0.92) for HPV status included age, smoking, and miRNAs: miR-15b, miR-20b, miR-29a, miR-29c, miR-142, miR-146a and miR-205. +other 33422804 hsa-mir-15b Squamous Cell Carcinoma of Head and Neck The best fitting model (AUC = 0.92) for HPV status included age, smoking, and miRNAs: miR-15b, miR-20b, miR-29a, miR-29c, miR-142, miR-146a and miR-205. +other 33422804 hsa-mir-29c Squamous Cell Carcinoma of Head and Neck The best fitting model (AUC = 0.92) for HPV status included age, smoking, and miRNAs: miR-15b, miR-20b, miR-29a, miR-29c, miR-142, miR-146a and miR-205. +other 33422804 hsa-mir-20b Squamous Cell Carcinoma of Head and Neck The best fitting model (AUC = 0.92) for HPV status included age, smoking, and miRNAs: miR-15b, miR-20b, miR-29a, miR-29c, miR-142, miR-146a and miR-205. +other 33422804 hsa-mir-146a Squamous Cell Carcinoma of Head and Neck The best fitting model (AUC = 0.92) for HPV status included age, smoking, and miRNAs: miR-15b, miR-20b, miR-29a, miR-29c, miR-142, miR-146a and miR-205. +genetics_overexpression_promote 33422779 hsa-mir-216b Stomach Neoplasms Besides, overexpression of miR-216b contributed to the activation of PI3K/AKT signaling via partly regulating PXN in GC cells. +genetics_GWAS 33422095 hsa-mir-690 Neurotic Disorders These results showed that miR-690 might play a role in stress resilience and could provide new insights into the epigenetic regulation of stress-associated biological functions and diseases, such as depression and post-traumatic stress disorder. +genetics_GWAS 33422095 hsa-mir-690 Stress Disorders, Post-Traumatic These results showed that miR-690 might play a role in stress resilience and could provide new insights into the epigenetic regulation of stress-associated biological functions and diseases, such as depression and post-traumatic stress disorder. +other 33422071 hsa-let-7a-2 Osteoarthritis Five sncRNAs were validated; miR-223 was significantly reduced in early osteoarthritis and miR-23b, let-7a-2, snord96A and snord13 were significantly upregulated. +other 33422071 hsa-mir-223 Osteoarthritis Five sncRNAs were validated; miR-223 was significantly reduced in early osteoarthritis and miR-23b, let-7a-2, snord96A and snord13 were significantly upregulated. +other 33422071 hsa-mir-23b Osteoarthritis Five sncRNAs were validated; miR-223 was significantly reduced in early osteoarthritis and miR-23b, let-7a-2, snord96A and snord13 were significantly upregulated. +other 33422052 hsa-mir-7 Carcinoma, Non-Small-Cell Lung 5p mimic. +transcription factor target 33421522 hsa-mir-183 Obesity SIGNIFICANCE: Our findings revealed that miR5p affected the regulation of hepatic TG homeostasis, which may provide a potential therapeutic target for hepatosteatosis. +other 33421513 hsa-mir-373 Pancreatic Carcinoma The ZIP4-miRLATS2-ZEB1/YAP1-ITGA3 signaling axis has a significant impact on pancreatic cancer metastasis and EMT plasticity. +lncRNA target 33421511 hsa-mir-10b Gastrointestinal Diseases CONCLUSIONS: miR-10b-5p is a key regulator in diabetes and gastrointestinal dysmotility via the KLF11-KIT pathway. +lncRNA target 33421511 hsa-mir-10b Diabetes Mellitus CONCLUSIONS: miR-10b-5p is a key regulator in diabetes and gastrointestinal dysmotility via the KLF11-KIT pathway. +other 33421490 hsa-mir-7 late onset Parkinson's disease In sum up, our study demonstrated a new regulatory network consisted of SOX21-AS1, miR5p and IRS2 in SH-SY5Y cells, supplying with a better comprehension about the pathogenic mechanism of PD. +circulation_biomarker_diagnosis_ns 33421274 hsa-mir-208a COVID-19 In both the discovery and the validation cohort, serum concentration of miR-21, miR-155, miR-208a and miR-499 were significantly increased in COVID-19 patients compared to healthy controls. +circulation_biomarker_diagnosis_ns 33421274 hsa-mir-499 COVID-19 In both the discovery and the validation cohort, serum concentration of miR-21, miR-155, miR-208a and miR-499 were significantly increased in COVID-19 patients compared to healthy controls. +circulation_biomarker_diagnosis_ns 33421274 hsa-mir-155 COVID-19 In both the discovery and the validation cohort, serum concentration of miR-21, miR-155, miR-208a and miR-499 were significantly increased in COVID-19 patients compared to healthy controls. +lncRNA target 33420627 hsa-mir-191 Acquired Immunodeficiency Syndrome infected patients and acts an inhibitor of HIV-1 infection via a mechanism that may involve targeted repression of NUP50 expression. +genetics_overexpression_promote 33420578 hsa-mir-29a Hemochromatosis Mcl-1 overexpression reversed miR-29a-mediated CM pyroptosis in an HR environment. +genetics_overexpression_suppress 33420578 hsa-mir-29a Mastocytosis, Cutaneous Mcl-1 overexpression reversed miR-29a-mediated CM pyroptosis in an HR environment. +genetics_overexpression_suppress 33420578 hsa-mir-29 Mastocytosis, Cutaneous Mcl-1 overexpression reversed miR-29a-mediated CM pyroptosis in an HR environment. +genetics_overexpression_promote 33420578 hsa-mir-29 Hemochromatosis Mcl-1 overexpression reversed miR-29a-mediated CM pyroptosis in an HR environment. +transcription factor target 33420548 hsa-mir-1246 Cystic Fibrosis MiR-1246 may be a potential therapeutic target for atherosclerosis. +genetics_GWAS 33420414 hsa-mir-221 Breast Neoplasms Our work elucidates an epigenetic mechanism of acquired chemoresistance in BC, in support of the METTL3/miR +other 33420363 hsa-mir-509 Carcinoma, Ovarian Epithelial 3-5p, and miR-514a-3p was remarkably less in recurrent cancer tissues when compared with that in paired primary cancer tissues. +other 33420363 hsa-mir-514a Carcinoma, Ovarian Epithelial 3-5p, and miR-514a-3p was remarkably less in recurrent cancer tissues when compared with that in paired primary cancer tissues. +other 33420276 hsa-mir-320d Myelodysplastic Syndromes High expression of miR-320d was an independent prognostic factor for OS in MDS. +lncRNA target 33420269 hsa-mir-299a Fibrosis, Renal Thus, miR299a-5p inhibition offers a potential novel therapeutic approach for CKD. +lncRNA target 33420081 hsa-mir-146a Lupus Erythematosus, Systemic Here, we report that the systemic lupus erythematosus (SLE) risk variant rs2431697 as likely causal for SLE through disruption of a regulatory element, modulating miR-146a expression. Finally, CRISPR activation-based modulation of this enhancer in the PBMCs of SLE patients attenuates type I interferon pathway activation by increasing miR-146a expression. +lncRNA target 33419984 hsa-mir-16 Colorectal Neoplasms Taken together, we disclose that CuET treatment plays an active role in inhibiting CRC progression via miR +lncRNA target 33419984 hsa-mir-15b Colorectal Neoplasms Taken together, we disclose that CuET treatment plays an active role in inhibiting CRC progression via miR +lncRNA target 33419758 hsa-mir-378a Insulin Resistance Our study delineated a novel mechanism of miR-378a in the pathogenesis of metabolic inflammation and insulin resistance through targeting metabolic signaling at both mRNA (e.g., PPARalpha) and protein (e.g., PKR) molecules. +lncRNA target 33419758 hsa-mir-378 Metabolic Diseases Our study delineated a novel mechanism of miR-378a in the pathogenesis of metabolic inflammation and insulin resistance through targeting metabolic signaling at both mRNA (e.g., PPARalpha) and protein (e.g., PKR) molecules. +lncRNA target 33419758 hsa-mir-378 Insulin Resistance Our study delineated a novel mechanism of miR-378a in the pathogenesis of metabolic inflammation and insulin resistance through targeting metabolic signaling at both mRNA (e.g., PPARalpha) and protein (e.g., PKR) molecules. +lncRNA target 33419758 hsa-mir-378a Metabolic Diseases Our study delineated a novel mechanism of miR-378a in the pathogenesis of metabolic inflammation and insulin resistance through targeting metabolic signaling at both mRNA (e.g., PPARalpha) and protein (e.g., PKR) molecules. +lncRNA target 33419582 hsa-mir-147a Squamous Cell Carcinoma of Head and Neck Silencing of MIAT suppressed LSCC progression through miR-147a/BCOR axis. +genetics_knock down_promote 33419488 hsa-mir-25 Breast Neoplasms 3p overexpression had similar effects with knockdown of S100A2 on BC cells. +lncRNA target 33419140 hsa-mir-200a Breast Neoplasms Our data demonstrate that ALDH(+) BCSC population contributes to breast tumor radioresistance via the Nrf2-Keap1 pathway, and targeting this cell population with miR200a could be beneficial but warrants detailed studies. +circulation_biomarker_diagnosis_up 33419057 hsa-mir-210 Carcinoma, Ductal, Breast We aimed to identify and validate miR-210 and miR-152 as non-invasive circulating biomarkers, for the diagnosis and staging of BC patients, confirming their involvement in tumor angiogenesis. The receiver operating characteristic (ROC) curve analysis revealed that only the expression of oncomiR-210 in tissue samples and only the expression of the miR-152 suppressor in plasma have the appropriate sensitivity and specificity for use as differential biomarkers between early/intermediate and advanced stages of BC patients. +circulation_biomarker_diagnosis_up 33419057 hsa-mir-152 Carcinoma, Ductal, Breast We aimed to identify and validate miR-210 and miR-152 as non-invasive circulating biomarkers, for the diagnosis and staging of BC patients, confirming their involvement in tumor angiogenesis. The receiver operating characteristic (ROC) curve analysis revealed that only the expression of oncomiR-210 in tissue samples and only the expression of the miR-152 suppressor in plasma have the appropriate sensitivity and specificity for use as differential biomarkers between early/intermediate and advanced stages of BC patients. +lncRNA target 33418541 hsa-mir-217 Carcinoma, Non-Small-Cell Lung In conclusion, this study reveals that the GAS5/miR-217/LHPP pathway reduces NSCLC cisplatin resistance and that LHPP may serve as a potential therapeutic target for NSCLC cisplatin resistance. +transcription factor target 33418009 hsa-mir-144 Sepsis 3 can promote LPS induced septic ALI through downregulating Caveolin-2 to activate the JAK/STAT signal pathway. +transcription factor target 33418009 hsa-mir-144 Acute Lung Injury 3 can promote LPS induced septic ALI through downregulating Caveolin-2 to activate the JAK/STAT signal pathway. +transcription factor target 33418009 hsa-mir-144 Inflammation Inflammation and cell apoptosis induced by LPS can be alleviated by miR +other 33417998 hsa-mir-150 Glomerulonephritis, IGA Thus, miR5p may be a potential functional mediator of kidney fibrosis that may add value in predicting risk of progression in IgA nephropathy and other kidney diseases. +transcription factor target 33417962 hsa-mir-471 Diabetic Cardiomyopathies CONCLUSION: Our results indicated that the development of DCM was related to AGEs-induced macrophage polarized to M1 type through a mechanism involving the miR +circulation_biomarker_diagnosis_ns 33417960 hsa-mir-22 Sepsis We aimed to investigate the effects of human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs)-derived exosomal microRNA +circulation_biomarker_diagnosis_ns 33417960 hsa-mir-22 Acute Lung Injury We aimed to investigate the effects of human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs)-derived exosomal microRNA +exosome 33417958 hsa-mir-129 Osteoarthritis 5p carried by exosomes from Human Synovial Mesenchymal Stem Cell (HS-MSC) on osteoarthritis(OA). +genetics_knock down_promote 33417325 hsa-mir-196b Stomach Neoplasms Moreover, ECRG4 overexpression showed similar effects with miR-196b inhibition on the malignant behaviors of GC cells and ECRG4 knockdown reversed the effects of miR-196b inhibition on gastric cancer cell proliferation, migration and invasion. +transcription factor target 33417281 hsa-mir-144 Uterine Cervical Neoplasms CEP55 was targeted by miR +transcription factor target 33417267 hsa-mir-218 Multiple Myeloma Taken together, miR-218 is decreased in MM that contributes to BTZ resistance via targeting LRRC28, which might be used as a novel therapeutic target for multiple myeloma. +circulation_biomarker_diagnosis_ns 33417162 hsa-mir-149 Stomach Neoplasms Furthermore, circ_0044516 mainly localized in the cytoplasm, which may act as a miR +transcription factor target 33417156 hsa-mir-378a Colonic Neoplasms Simultaneously, this study shows the correlation between the CBX8/miR-378a-3p/PDIA4 pathway and the malignant biological properties of colorectal cancer, suggesting this proposed pathway as a possible therapeutic target for human cancers. +genetics_overexpression_promote 33416962 hsa-mir-495 Cystitis, Interstitial The current study was aimed at elucidating the effects associated with miR-495 on the inflammatory response and bladder fibrosis in rats with ulcerative IC via the JAK-STAT pathway by targeting JAK3. CONCLUSIONS: Collectively, our key findings provide evidence supporting the notion that the overexpression of miR-495 ameliorates inflammatory response and bladder fibrosis in ulcerative IC rat models via inactivation of the JAK-STAT signaling pathway by inhibiting JAK3. +lncRNA target 33416495 hsa-mir-181b Vasculitis Herein, we identify that the drug methotrexate (MTX) and its downstream metabolite adenosine exert anti-inflammatory effects in the vascular endothelium by targeting and activating Mir181b expression. +other 33416420 hsa-mir-487a Prostatic Neoplasms The expressions of SNHG3, miR-487a-3p, E-cadherin, N-cadherin, Snail, and TRIM25 in PCa tissues and cells were measured by quantitative reverse transcription polymerase chain reaction or Western blot. Conclusion: SNHG3 mediates PCa migration, invasion, and EMT by sponging miR-487a-3p to regulate TRIM25. +other 33416186 hsa-mir-145 Carcinoma, Non-Small-Cell Lung In conclusion, hsa_circ_0016760 exacerbated the malignant development of NSCLC by sponging miR1455p/FGF5. +other 33416185 hsa-mir-490 Carcinoma, Ductal, Breast On the whole, the results confirm a prometastatic role of miR4903p in IDC, establishing it as a biomarker for disease progression in these patients. +genetics_overexpression_promote 33416181 hsa-mir-181a Osteosarcoma Additionally, the results of rescue experiments suggested that overexpression of miR181a neutralized the inhibitory effects of TUSC7 overexpression on OS cells. Overall, the present study demonstrated that the tumor suppressor role of TUSC7 in OS progression was mediated through the miR181a/RASSF6 axis, which may represent a new therapeutic target for OS. +genetics_knock down_suppress 33416178 hsa-mir-196a Lymphoma, Large B-Cell, Diffuse It was shown that the overexpression of miR196a3p was associated with cell cycle arrest, enhanced apoptosis, and inhibited proliferation in DLBCL cells. +genetics_overexpression_promote 33416170 hsa-mir-199b Ovarian Neoplasms Furthermore, miRNA199b3p overexpression reduced cell proliferation and promoted apoptosis in an in vitro model of ovarian cancer. +other 33416169 hsa-mir-454 Glioma The results demonstrated that the CASC19/miR4543p/RAB5A axis is involved in the promotion of glioma progression. +lncRNA target 33416166 hsa-mir-184 Uterine Cervical Neoplasms Treatment of cervical cancer cells with the p53 activator Mithramycin A restored the levels of the endogenous ERBB2 inhibitor miR31845p and may represent a novel treatment strategy for cervical cancer. +genetics_knock down_promote 33416160 hsa-mir-423 Lymphoma, Mantle-Cell In addition, rescue assay showed that miR4235p upregulation or NACC1 knockdown abolished the promoting effects of FOXP4AS1 on MCL cell proliferation, migration and invasion. +other 33416153 hsa-mir-422a Carcinoma, Non-Small-Cell Lung Taken together, these results revealed the novel role of the GACAT1/miR422a pathway in the progression of NSCLC cell lines, providing a possible therapeutic strategy for NSCLC treatment. +genetics_knock down_promote 33416148 hsa-mir-338 Carcinoma, Hepatocellular The inhibition of miR338 partially reversed the inhibitory effects of ST8SIA6AS1knockdown on the migration and invasion of HCC cells under hypoxia. In conclusion, the findings of the present study suggest that lncRNA ST8SIA6AS1 may promote the migration and invasion of hypoxiainduced HCC cells via the miR338/MEPCE axis, indicating a potential diagnostic or therapeutic marker for HCC treatment. +lncRNA target 33416147 hsa-mir-637 Osteosarcoma It was revealed that miR637 suppressed OS cell proliferation, migration and invasion via targeting of HDAC4. +genetics_knock down_promote 33416140 hsa-mir-142 Neuralgia In the fourth part, the rats were divided into the Sham, CCI, miR1423p siRNA, AC9 mimic, miR1423p siRNA AC9 siRNA, cAMP activator (Forskolin) and miR1423p siRNA cAMP inhibitor groups. +epigenetics 33416135 hsa-mir-29b Pancreatic Carcinoma Then the methylation levels of miR29b3p in human pancreatic cancer tissues and cell lines were detected by pyrosequencing, and the relative expression of miR29b3p was assessed in pancreatic cancer tissues by qPCR. +lncRNA target 33416133 hsa-mir-34a Colorectal Neoplasms Luciferase assay and western blotting were performed to demonstrate miR34a as a downstream target gene of GAS5 in CRC cells. +genetics_overexpression_promote 33416118 hsa-mir-34a Parkinson Disease These results underline the necessity to examine the miRNA content of each EV subpopulation to identify miRNA candidates with potential diagnostic value and lay the basis for future studies to validate the overexpression of circulating miR34a5p in PD via the use of pure SEVs. +lncRNA target 33416111 hsa-mir-882 Osteoporosis The present results indicated that the miR882/Reverbalpha axis may serve a vital role in inhibiting osteoclastogenesis following RANKL and MCSF treatment, indicating that Reverbalpha agonism or miR882 inhibition may represent mechanisms through which melatonin prevents osteoporosis. +circulation_biomarker_diagnosis_ns 33416109 hsa-mir-126 Diabetic Retinopathy The expression of microRNA126 (miRNA/miR126) has previously been found to be significantly decreased in the serum of patients with DR. Thus, miR126 and CFI400945 fumarate may be therapeutic targets for DR. +exosome 33416108 hsa-mir-494 Myocardial Infarction Dendritic cell-derived exosomal miR-494-3p promotes angiogenesis following myocardial infarction. +lncRNA target 33416105 hsa-mir-124 Ovarian Neoplasms The results revealed that hsa_circ_0026123 silencing suppressed ovarian cancer cell progression via the miR1243p/EZH2 signaling pathway. +lncRNA target 33416104 hsa-mir-214 Teratocarcinoma, Ovarian Taken together, these results demonstrated that LINC00324 could serve as a competing endogenous RNA to facilitate IOT cell proliferation by regulation of miR2145pCDK6/CCND1/MDM2/MDM4 network, which possibly provide a novel therapeutic target for IOT. +lncRNA target 33416100 hsa-mir-1306 Angelman Syndrome SIRT7 was validated to be a target gene of miR13065p, exhibiting similar inhibitory effects as SNHG7003 in AS. +lncRNA target 33416094 hsa-mir-142 AIDS-Related Complex Programmed cell death 1 ligand 1 (PDL1) was also found to be a key effector of the FGD5AS1/miR142 axis to regulate the chemoresistance of DDPresistant LAD cells. In conclusion, the present study demonstrated that FGD5AS1 increased DDP resistance of LAD via the miR142/PDL1 axis, which may offer a novel treatment strategy for patients with DDPresistant LAD. +lncRNA target 33416089 hsa-mir-3666 Osteosarcoma Collectively, the present study demonstrates that KCNQ1OT1 facilitates OS progression and activates Wnt/betacatenin signaling by targeting the miR3666/KLF7 axis. +other 33416075 hsa-mir-1 Sepsis MiR3p and SERP1 may be promising therapeutic candidates for sepsis-induced lung injury. +lncRNA target 33416035 hsa-mir-1269 Esophageal Squamous Cell Carcinoma CONCLUSION: These results suggest that miR-1269 plays an important role in the progression of ESCC by targeting SOX6 and may be a potential prognostic biomarker and the miR-1269/SOX6 axis may be a therapeutic target for the patient with ESCC. +circulation_biomarker_diagnosis_ns 33415768 hsa-mir-1 Sarcoidosis METHODS: For this case-control study, expression of serum eca-miR-331, eca-miR-100, and eca-miR-1 in ES-affected equids was compared to tumor-free age-, sex-, and breed-matched control horses and donkeys with other skin tumors using reverse transcription quantitative PCR (polymerase chain reaction) for relative miRNA quantification. +genetics_knock down_promote 33415690 hsa-mir-501 Osteosarcoma 3p overexpression in Saos-2 cells promoted cell proliferation, migration and invasion. +genetics_overexpression_promote 33415668 hsa-mir-23b Acute Lung Injury In this study, we aimed to explore the interaction between miR-23b and HDAC2 and their function in LPS-induced ALI. Overexpression of miR-23b was sufficient to suppress inflammatory responses by targeting HDAC2, making it a promising therapeutic target to ALI treatment. +genetics_knock down_promote 33415607 hsa-mir-203a Bronchopulmonary Dysplasia In summary, the findings of our study indicate that miR-203a-3p knockdown alleviates hyperoxia-induced lung tissue damage in the BPD rat model, and its effect may be associated with the up-regulation of VEGF. +other 33415167 hsa-mir-335 Pancreatic Carcinoma The LINC01503/miR5p/P4HA1 axis might mediate the effects of P4HA1 in promoting the progression on pancreatic cancer. +other 33415165 hsa-mir-21 Carcinoma, Hepatocellular CONCLUSIONS: Our study demonstrated that miR-21 high expression among surgically resected HCC patients is a prognostic factor that indicated adverse survival. +exosome 33415108 hsa-mir-216 Reperfusion Injury, Renal Ischemia Potentially, USCs-Exos rich in miR-216a-5p can serve as a promising therapeutic option for AKI. +exosome 33415108 hsa-mir-216a Reperfusion Injury, Renal Ischemia Potentially, USCs-Exos rich in miR-216a-5p can serve as a promising therapeutic option for AKI. +therapeutic target 33415004 hsa-mir-29b Osteosarcoma miR-29b mimic improved the radiosensitivity of OSA cells via the PTEN-AKT-Sp1 signaling pathway, presenting a novel strategy for the development of carbon ion beam combination therapy. +other 33414912 hsa-mir-373 Breast Neoplasms As a representative example, combinations of four miRNAs (miR-1246+miR-206+miR-24+miR-373) of the nine miRNAs had a sensitivity of 98%, a specificity of 96% and an accuracy of 97% for breast cancer detection in the validation cohort. +other 33414912 hsa-mir-1246 Breast Neoplasms As a representative example, combinations of four miRNAs (miR-1246+miR-206+miR-24+miR-373) of the nine miRNAs had a sensitivity of 98%, a specificity of 96% and an accuracy of 97% for breast cancer detection in the validation cohort. +other 33414912 hsa-mir-206 Breast Neoplasms As a representative example, combinations of four miRNAs (miR-1246+miR-206+miR-24+miR-373) of the nine miRNAs had a sensitivity of 98%, a specificity of 96% and an accuracy of 97% for breast cancer detection in the validation cohort. +other 33414912 hsa-mir-24 Breast Neoplasms As a representative example, combinations of four miRNAs (miR-1246+miR-206+miR-24+miR-373) of the nine miRNAs had a sensitivity of 98%, a specificity of 96% and an accuracy of 97% for breast cancer detection in the validation cohort. +transcription factor target 33414893 hsa-mir-429 Colorectal Neoplasms We further identified miR-429 as a direct regulator of LATS2-YAP/TAZ activation, suggesting that the miRLATS2-YAP/TAZ might be novel effective diagnostic axis and therapeutic targets for CRC. +transcription factor target 33414831 hsa-mir-15a Leukemia, Myelogenous, Chronic, BCR-ABL Positive The results demonstrated that hBMMSC-Exo had the ability to inhibit the proliferation of CML cells in vitro via miR-15a and arrest cell cycle in the G0/G1 phase. +target gene 33414806 hsa-mir-708 Osteosarcoma Schisandrin B Inhibits Cell Viability and Migration, and Induces Cell Apoptosis by circ_0009112/miR-708-5p Axis Through PI3K/AKT Pathway in Osteosarcoma. +genetics_overexpression_promote 33414521 hsa-mir-519a Carcinoma, Non-Small-Cell Lung Overexpression of EphA2 reversed the promotion of upregulated miR-519a on radiosensitivity of NSCLC cells. +lncRNA target 33414461 hsa-mir-98 Ischemic Stroke Furthermore, we showed that neurons transferred miR-98 to microglia via EVs secretion after ischemic stroke, to prevent the stress-but-viable neurons from microglial phagocytosis. +lncRNA target 33414440 hsa-mir-153 Carcinoma, Renal Cell 5p/AGO1 axis was responsible for tumor occurrence and progression via PI3K/Akt signaling, which may therefore provide promising therapeutic targets and prognostic biomarkers for patients with ccRCC. +lncRNA target 33414427 hsa-mir-653 Carcinoma, Hepatocellular GOLM1 axis, which may help develop prognostic biomarkers and therapeutic target for HCC. +lncRNA target 33414426 hsa-mir-93 Ocular Hypertension The miR-93 level was significantly reduced in the retinae of rat acute ocular hypertension (AOH) models, which were accompanied by retinal microglial activation, overproduction of inflammatory cytokines, and subsequent retinal ganglion cells (RGCs) death, versus the retinae of controls. Regulating microglial activation through miR-93 may serve as a target for neuroprotective therapy in pathological ocular hypertension. +exosome 33414420 hsa-mir-145 Breast Neoplasms STIM1 promotes angiogenesis by reducing exosomal miR-145 in breast cancer MDA-MB-231 cells. Taken together, our findings suggest that STIM1 promotes angiogenesis by reducing exosomal miR-145 in breast cancer MDA-MB-231 cells. +lncRNA target 33414247 hsa-mir-378 Metabolic Diseases Conclusion: Our study delineated a novel mechanism of miRNA-378a in the pathogenesis of metabolic inflammation and insulin resistance through targeting metabolic signaling at both mRNA (e.g., PPARalpha) and protein (e.g., PKR) molecules. +lncRNA target 33414247 hsa-mir-378 Insulin Resistance Conclusion: Our study delineated a novel mechanism of miRNA-378a in the pathogenesis of metabolic inflammation and insulin resistance through targeting metabolic signaling at both mRNA (e.g., PPARalpha) and protein (e.g., PKR) molecules. +lncRNA target 33414247 hsa-mir-378a Insulin Resistance Conclusion: Our study delineated a novel mechanism of miRNA-378a in the pathogenesis of metabolic inflammation and insulin resistance through targeting metabolic signaling at both mRNA (e.g., PPARalpha) and protein (e.g., PKR) molecules. +lncRNA target 33414247 hsa-mir-378a Metabolic Diseases Conclusion: Our study delineated a novel mechanism of miRNA-378a in the pathogenesis of metabolic inflammation and insulin resistance through targeting metabolic signaling at both mRNA (e.g., PPARalpha) and protein (e.g., PKR) molecules. +other 33413921 hsa-mir-15a Wounds and Injuries CONCLUSION Assessment of the bone marrow microRNA profile in trauma patients compared to those undergoing elective hip replacement revealed the differential expression of microRNA-150, microRNA-223, microRNA-15a, and microRNA-24. +other 33413921 hsa-mir-150 Wounds and Injuries CONCLUSION Assessment of the bone marrow microRNA profile in trauma patients compared to those undergoing elective hip replacement revealed the differential expression of microRNA-150, microRNA-223, microRNA-15a, and microRNA-24. +other 33413921 hsa-mir-223 Wounds and Injuries CONCLUSION Assessment of the bone marrow microRNA profile in trauma patients compared to those undergoing elective hip replacement revealed the differential expression of microRNA-150, microRNA-223, microRNA-15a, and microRNA-24. +other 33413921 hsa-mir-24 Wounds and Injuries CONCLUSION Assessment of the bone marrow microRNA profile in trauma patients compared to those undergoing elective hip replacement revealed the differential expression of microRNA-150, microRNA-223, microRNA-15a, and microRNA-24. +genetics_overexpression_promote 33413674 hsa-mir-125a Atrial Premature Complexes Mechanistically, this study found that downregulating ANRIL led to the overexpression of microRNA-125a (miR-125a), and further contributed to the competitive binding of miR-125a and adenomatous polyposis coli (APC), thus significantly activating the Wnt/beta-catenin pathway. +lncRNA target 33413674 hsa-mir-125a Periodontitis CONCLUSION: The study indicated that HAMSCs promoted the osteogenic differentiation of LPS-induced HBMSCs via the ANRIL/miR-125a/APC axis, and offered a novel approach for periodontitis therapy. +genetics_overexpression_promote 33413674 hsa-mir-125a Adenomatous Polyposis Coli Mechanistically, this study found that downregulating ANRIL led to the overexpression of microRNA-125a (miR-125a), and further contributed to the competitive binding of miR-125a and adenomatous polyposis coli (APC), thus significantly activating the Wnt/beta-catenin pathway. CONCLUSION: The study indicated that HAMSCs promoted the osteogenic differentiation of LPS-induced HBMSCs via the ANRIL/miR-125a/APC axis, and offered a novel approach for periodontitis therapy. +other 33413642 hsa-mir-26a Femur Head Necrosis RESULTS NORAD expression was downregulated in SONFH tissues, while miR-26a-5p expression was upregulated. CONCLUSIONS NORAD expression was downregulated in SONFH tissues, while miR-26a-5p expression was upregulated. +genetics_overexpression_promote 33413595 hsa-mir-27b Sepsis We induced miR-27b overexpression or downregulation, along with silencing of JMJD3 or NF-kappaB to examine their effects on sepsis. +exosome 33413589 hsa-mir-130a Ovarian Neoplasms We also found that miR-130a was highly expressed in drug-resistant OC cells. Therefore, we suggest that miR-130a in exosomes is the main cause of chemoresistant OC cells promoting angiogenesis. +exosome 33413548 hsa-mir-27b Neovascularization, Pathologic Human umbilical cord mesenchymal stem cell-derived exosomal miR-27b attenuates subretinal fibrosis via suppressing epithelial-mesenchymal transition by targeting HOXC6. CONCLUSIONS The present study showed that HucMSC-derived exosomal miR-27b could reverse the process of EMT induced by TGF-2 via inhibiting HOXC6, indicating that the exosomal miR-27b/HOXC6 axis might play a vital role in ameliorating subretinal fibrosis. +exosome 33413543 hsa-mir-186 Osteoporosis, Postmenopausal CONCLUSIONS: We concluded that exosomes derived from human bone marrow mesenchymal stem cells (hBMSCs) can transfer miR-186 to promote osteogenesis in ovariectomy (OVX) rats through the Hippo signaling pathway. +transcription factor target 33413477 hsa-mir-573 Intervertebral Disc Degeneration CONCLUSION: Mir-573 regulates cell proliferation and apoptosis by targeting Bax in human degenerative NP cells following HBO treatment. +transcription factor target 33413440 hsa-mir-492 Endometrial Neoplasms CONCLUSION: Metapristone inhibited the endometrial cancer cell growth through regulating the cell apoptosis-related signaling pathway and decreasing the expression of miR-492 and its downstream target genes (Klf5 and Nrf1), which provided the theoretical basis in clinical treatment of endometrial cancer. +circRNA target 33413420 hsa-mir-138 salivary gland adenoid cystic carcinoma Moreover, the predicted molecular interaction proved that circRNA ABCA13 may promote SACC through inhibition of miR5p. +other 33413401 hsa-mir-515 Glioma CONCLUSIONS: Overall, the study illustrated that CircPIP5K1A is a potential prognostic marker in glioma and regulates glioma evolvement by modulating the miR5p-mediated TCF12/PI3K/AKT axis. +other 33413360 hsa-mir-137 Uterine Cervical Neoplasms CircNEIL3 promotes cervical cancer cell proliferation by adsorbing miR-137 and upregulating KLF12. +target gene 33413358 hsa-mir-454 Uterine Cervical Neoplasms Linc00887 suppresses tumorigenesis of cervical cancer through regulating the miR-454-3p/FRMD6-Hippo axis. +other 33413071 hsa-mir-10a Heart Failure MiR-10a-5p and miR5p were differentially expressed in LF and HF samples (false discovery rate < 10%). +other 33413071 hsa-mir-9 Heart Failure MiR-10a-5p and miR5p were differentially expressed in LF and HF samples (false discovery rate < 10%). +genetics_knock down_promote 33413028 hsa-mir-149 Carcinoma, Non-Small-Cell Lung Our results suggested that circ-FOXM1 knockdown attenuated the development of NSCLC through modulating the miR +transcription factor target 33412224 hsa-mir-10b Triple Negative Breast Neoplasms HA-GO-Met nanoparticles induced apoptosis and inhibited cell migration of TNBC cells by targeting miR-10b/PTEN axis via NFkB-p65. +circulation_biomarker_diagnosis_ns 33411988 hsa-mir-125b Diabetes, Gestational CONCLUSIONS: These findings suggest that miRNA-125b and miRNA-144 are consistently dysregulated in circulating exosomes and the placenta from GDM pregnancies, and are of excellent diagnostic value for GDM. +circulation_biomarker_diagnosis_ns 33411988 hsa-mir-144 Diabetes, Gestational CONCLUSIONS: These findings suggest that miRNA-125b and miRNA-144 are consistently dysregulated in circulating exosomes and the placenta from GDM pregnancies, and are of excellent diagnostic value for GDM. +other 33411678 hsa-mir-16 Scleroderma, Systemic 5p downregulation and NOTCH2 upregulation was also confirmed in vivo in SSc patients, and NOTCH2 activation promoted fibrosis progression in vitro. +transcription factor target 33411212 hsa-mir-520c Vascular Diseases This study aims to investigate the functional role of miR-520c-3p in vascular endothelium during inflammatory diseases such as atherosclerosis. We conclude that miR-520c-3p may play an important role in the suppression of endothelial injury, which could serve as a biomarker and therapeutic target for atherosclerosis. +genetics_knock down_promote 33410769 hsa-mir-1906 Osteoporosis In conclusion, the miR-1906 mimic reduces bone loss in rats with ovariectomy-induced osteoporosis by regulating the TLR4/MyD88/NF-kappaB pathway. +lncRNA target 33410459 hsa-mir-138 Hepatitis B Such an effect suggests that miR-138 may serve as a new therapeutic target for the treatment of HBV infection. +lncRNA target 33410377 hsa-mir-129 Alzheimer Disease This study suggests that silenced H19 and up-regulated miR-129 accelerates viability and represses apoptosis of PC12 cells stimulated by Abeta(25-35) in AD, which is beneficial for AD treatment. +other 33410199 hsa-mir-181a Alveolar echinococcosis 3p, were found as up-regulated in Alveolar and Cystic Echinococcosis patients than healthy person. +other 33410199 hsa-mir-29a Alveolar echinococcosis 3p, were found as up-regulated in Alveolar and Cystic Echinococcosis patients than healthy person. +other 33410199 hsa-mir-214 Alveolar echinococcosis 3p, were found as up-regulated in Alveolar and Cystic Echinococcosis patients than healthy person. +other 33410199 hsa-mir-181d Alveolar echinococcosis 3p, were found as up-regulated in Alveolar and Cystic Echinococcosis patients than healthy person. +other 33410199 hsa-mir-195 Alveolar echinococcosis 3p, were found as up-regulated in Alveolar and Cystic Echinococcosis patients than healthy person. +other 33410199 hsa-mir-181c Alveolar echinococcosis 3p, were found as up-regulated in Alveolar and Cystic Echinococcosis patients than healthy person. +other 33410199 hsa-mir-181b Alveolar echinococcosis 3p, were found as up-regulated in Alveolar and Cystic Echinococcosis patients than healthy person. +other 33410199 hsa-mir-27a Alveolar echinococcosis 3p, were found as up-regulated in Alveolar and Cystic Echinococcosis patients than healthy person. +other 33410199 hsa-mir-15a Alveolar echinococcosis 3p, were found as up-regulated in Alveolar and Cystic Echinococcosis patients than healthy person. +other 33410199 hsa-mir-365 Alveolar echinococcosis 3p, were found as up-regulated in Alveolar and Cystic Echinococcosis patients than healthy person. +other 33410199 hsa-mir-21 Alveolar echinococcosis 3p, were found as up-regulated in Alveolar and Cystic Echinococcosis patients than healthy person. +genetics_knock down_suppress 33410156 hsa-mir-142 Carcinoma, Hepatocellular 3p overexpression restrained the growth and motility of HCC cells, with HOXA1 elevation reversing the impacts. +exosome 33410095 hsa-mir-381 Triple Negative Breast Neoplasms miRNA-381 is one of the downregulated miRNAs in several cancers including triple-negative breast cancer (TNBC) and restoration of its expression in TNBC cells can restrict their migratory ability through targeting several signaling pathways. In current study, we exploited the exosomes isolated from adipose-derived mesenchymal stem cells (ADMSC-exosomes) to deliver miR-381 mimic to MDA-MB-231 cells to elucidate their effects on TNBC cells. +circulation_biomarker_diagnosis_ns 33409960 hsa-mir-134 Pulmonary Embolism Circulating microRNA-134 may be a new biomarker for the diagnosis of APE, but more tests and studies are needed to further explore and prove this. +other 33409877 hsa-mir-146a Pneumonia, Mycoplasma SIRT2 and atypical chemokine receptor 2 (ACKR2) were downregulated while miR-146a was upregulated in PE patients. ACKR2 was downregulated in tissues from PE women and its upregulation blocked the role of miR-146a. +circulation_biomarker_diagnosis_up 33409855 hsa-mir-377 Brain Ischemia We found in IS serum samples, RMST was upregulated while miR-377 was downregulated. Collectively, all these findings clarified that RMST repression retarded IS progression in vitro via SEMA3A downregulation by targeting miR-377, which represented a different perspective in the pathological development of IS. +circulation_biomarker_diagnosis_up 33409855 hsa-mir-377 Ischemic Stroke We found in IS serum samples, RMST was upregulated while miR-377 was downregulated. Collectively, all these findings clarified that RMST repression retarded IS progression in vitro via SEMA3A downregulation by targeting miR-377, which represented a different perspective in the pathological development of IS. +circRNA target 33408787 hsa-mir-93 Osteoarthritis Conclusion: We identified a circRSU1-miR5p-MAP3K8 axis that modulates the progression of OA via oxidative stress regulation, which could serve as a potential target for OA therapy. +lncRNA target 33408612 hsa-mir-125b Alzheimer Disease In conclusion, targeting miR-125b alleviates AD progression via blocking PTGS2 and CDK5 in a FOXQ1-dependent way. +target gene 33408528 hsa-mir-20b Osteosarcoma FGD5-AS1 is highly expressed in osteosarcoma and is involved in the biological procession of osteosarcoma by targeting miR-320b. +exosome 33408524 hsa-mir-499 Endometrial Neoplasms CONCLUSION: The novel identified exosomal miR-499 functions as a tumor suppressor in endometrial cancer though regulating VAV3, and these findings could be a valid molecular target for endometrial cancer therapy. +genetics_knock down_promote 33408523 hsa-mir-411 Carcinoma, Renal Cell Circ_101341 directly targeted miR-411, and miR-411 inhibition revised the inhibitory effects of circ_101341 knockdown on proliferation, migration and invasion in ccRCC cells. CONCLUSION: Circ_101341 functioned as a tumor promoter to strengthen proliferation, migration and invasion by regulating EGLN3 via sponging miR-411, indicating that circ_101341 was a potential diagnostic and therapeutic biomarker of ccRCC. +genetics_overexpression_promote 33408518 hsa-mir-34a Retinoblastoma Overexpression of CASC8 decreased expression of miR34a and increased methylation of MIR 34A in Rb cells. +genetics_overexpression_promote 33408518 hsa-mir-34 Retinoblastoma Overexpression of CASC8 decreased expression of miR34a and increased methylation of MIR 34A in Rb cells. +genetics_overexpression_promote 33408517 hsa-mir-21 Endometrial Neoplasms In EC cells, overexpression of RUNX1-IT1 downregulated mature miR-21, but not miR-21 precursor. +lncRNA target 33408514 hsa-mir-383 Medulloblastoma CircSKA3 depletion decreased FOXM1 expression via miR +genetics_overexpression_promote 33408513 hsa-mir-423 Thyroid Neoplasms 5p, and its overexpression could weaken the anti-tumor effect of this miR on TC cells. +other 33408485 hsa-mir-29b Esophageal Neoplasms LncRNA GIHCG Promotes the Development of Esophageal Cancer by Modulating miR-29b-3p/ANO1 Axis. +lncRNA target 33408482 hsa-mir-130a Carcinoma, Hepatocellular SNX5 was identified as a target gene of miR-130a-5p, and circ_0001175 could sponge miR-130a-5p and up-regulate the expression of SNX5 in HCC cells. +other 33408470 hsa-mir-218 Pulmonary Disease, Chronic Obstructive However, the potential roles and functional effects of miR-218 in COPD remain undefined. RESULTS: MiR-218 was downregulated in COPD and CSE-induced BEAS-2B cells, and it was positively correlated with forced expiratory volume in 1 second (FEV1) % in COPD patients. +genetics_knock down_promote 33408314 hsa-mir-23b Fibrosis, Renal In conclusion, our results suggested that PVT1 knockdown suppressed DN progression though functioning as ceRNA of miR-23b-3p to regulate EGR1 expression in vitro, providing potential value for the treatment of DN. +circRNA target 33407952 hsa-mir-203 Arthritis, Rheumatoid CONCLUSION: Circ_0000396 inhibited the growth and inflammation in RASFs by regulating miR-203/HBP1 axis, providing a potential therapeutic target for RA. +other 33407852 hsa-mir-125a Leukemia, Myelomonocytic, Chronic These data were validated in a clinical context, as miR-125a expression increased after HMA treatment in CMML patients, a phenomenon that was particularly pronounced in cases showing clinical response to these drugs. CONCLUSIONS: Taken together, we report decreased expression of miR-125a in CMML and delineate its relevance as mediator of HMA efficacy within this neoplasia. +genetics_knock down_suppress 33407764 hsa-mir-145 Ovarian Neoplasms Together, our results revealed that berberine inhibited proliferation, migration and invasion through miR-145/MMP16 in SKOV3 and 3AO cells, highlighting the potentiality of berberine to be used as a therapeutic agent for ovarian cancer. +lncRNA target 33407761 hsa-mir-145 Heart Arrest CONCLUSIONS: Sildenafil group had better outcomes in terms of hemodynamic and oxygen metabolism parameters as well as 24-h survival rate, inhibited the increases in the miR +lncRNA target 33407761 hsa-mir-155 Heart Arrest CONCLUSIONS: Sildenafil group had better outcomes in terms of hemodynamic and oxygen metabolism parameters as well as 24-h survival rate, inhibited the increases in the miR +lncRNA target 33407724 hsa-mir-26a Carcinoma, Non-Small-Cell Lung Mechanistically, lnc-GAN1 acts as a sponge for miR-26a-5p by two seed sequences, and the two non-coding RNAs have a negative relationship in NSCLC tissues; we further prove that PTEN is a direct target of miR-26a-5p and lnc-GAN1 inhibits cell cycle signaling pathway by activating PTEN, whose expression level correlated negatively with miR-26a-5p level but positively with lnc-GAN1 level in NSCLC samples. CONCLUSIONS: Lnc-GAN1 is downregulated and associated with poor survival of NSCLC patients, and mechanistically acts as a tumor suppressor via sponging and inhibiting miR-26a-5p to upregulate PTEN. +circulation_biomarker_diagnosis_up 33407703 hsa-mir-375 Glioma containing exosomes were also identified in human peripheral blood samples from glioma patients, and their level correlated with disease progression status. +other 33407691 hsa-mir-1249 Osteoporosis-pseudoglioma syndrome Moreover, miR5p was decreased in OP patients, while showed a gradual increase with the extension of induction time. +genetics_knock down_promote 33407665 hsa-mir-222 Spinal Cord Injuries CONCLUSION: In summary, these findings ascertain that knockdown of LEF1-AS1 impedes SCI progression via the miR +lncRNA target 33407653 hsa-mir-142 Fragile X Syndrome CONCLUSIONS: The results revealed miR-142 downregulation could alleviate PTSD-like behaviors through attenuating neuroinflammation in the hippocampus of SPS rats by binding to FMRP. +lncRNA target 33407653 hsa-mir-142 Stress Disorders, Post-Traumatic CONCLUSIONS: The results revealed miR-142 downregulation could alleviate PTSD-like behaviors through attenuating neuroinflammation in the hippocampus of SPS rats by binding to FMRP. +lncRNA target 33407592 hsa-mir-587 Prostatic Neoplasms CONCLUSION: PGM5-AS1 upregulates GDF10 gene expression by competitively binding to miR-587, thus inhibiting proliferation and accelerating apoptosis of PCa cells. +genetics_knock down_promote 33407591 hsa-mir-424 Ovarian Neoplasms In addition, the effects of EVs-delivered miR-424 on the proliferation, migration, invasion and tube formation of ovarian cancer cells were assessed using gain- and loss-of-function approaches. +other 33407587 hsa-mir-212 Arthritis, Rheumatoid 3p/miR-129 are potential RNA regulatory pathways that control disease progression in early RA. +other 33407587 hsa-mir-25 Arthritis, Rheumatoid 3p/miR-129 are potential RNA regulatory pathways that control disease progression in early RA. +other 33407587 hsa-mir-129 Arthritis, Rheumatoid 3p/miR-129 are potential RNA regulatory pathways that control disease progression in early RA. +other 33407587 hsa-mir-132 Arthritis, Rheumatoid 3p/miR-129 are potential RNA regulatory pathways that control disease progression in early RA. +exosome 33407563 hsa-mir-342 Colorectal Neoplasms CONCLUSION: Collected evidence supported that CAFs-derived exosomal LINC00659 promotes CRC cell proliferation, invasion and migration via miR +transcription factor target 33407520 hsa-mir-29b Colorectal Neoplasms Transfection with miR-29b mimic, siRNA-ETV4, or ERK signaling pathway inhibitor U0126 increased expression of E-cadherin and TSP-1, and CRC cell apoptosis, yet reduced expression of ERK1/2, MMP-2, MMP-9, Vimentin, and VEGF, as well as inhibiting EMT, angiogenesis, and CRC cell migration and invasion. +transcription factor target 33407520 hsa-mir-29 Colorectal Neoplasms Transfection with miR-29b mimic, siRNA-ETV4, or ERK signaling pathway inhibitor U0126 increased expression of E-cadherin and TSP-1, and CRC cell apoptosis, yet reduced expression of ERK1/2, MMP-2, MMP-9, Vimentin, and VEGF, as well as inhibiting EMT, angiogenesis, and CRC cell migration and invasion. +transcription factor target 33407516 hsa-mir-4521 Stomach Neoplasms Functional experiments revealed that miR-4521 inhibited GC cell invasion and metastasis in vitro and in vivo. +target gene 33407514 hsa-mir-452 Uterine Cervical Neoplasms Circ-CCDC66 upregulates REXO1 expression to aggravate cervical cancer progression via restraining miR-452-5p. +genetics_knock down_promote 33407505 hsa-mir-195 Carcinoma, Non-Small-Cell Lung CONCLUSION: Circ_ZFR knockdown played a positive role in overcoming PTX resistance of NSCLC via regulating miR +lncRNA target 33407504 hsa-mir-139 Pituitary Neoplasms CONCLUSION: PCAT6 regulated the progression of PA via modulating the miR +lncRNA target 33407499 hsa-mir-497 Carcinoma, Hepatocellular CONCLUSIONS: DLG1-AS1 is activated by MYC and functions as an oncogene in HCC via miR +lncRNA target 33407453 hsa-mir-29a Stomach Neoplasms Bioinformatics analyses and integrated experiments revealed that LIFR-AS1 elevated the expression of COL1A2 through sponging miR-29a-3p, which further resulted in the progression of gastric tumor. +genetics_knock down_promote 33407443 hsa-mir-877 Carcinoma, Hepatocellular PIK3R3 overexpression reversed the suppressive influence of miR +lncRNA target 33407350 hsa-mir-381 Urinary Bladder Neoplasms Up-regulation of miR-381 suppresses BCa development both in vivo and in vitro through BMI1 down-regulation and the Rho/ROCK inactivation. +transcription factor target 33406505 hsa-mir-132 Diabetic Neuropathies These findings suggest that miR-132 exerts protective effects from DE injury by repressing GSK-3beta expression and alleviating Tau hyperphosphorylation in HT-22 cells and hippocampus tissues. +circulation_biomarker_diagnosis_ns 33406428 hsa-mir-29 Inflammation Mechanistically, our data show that miR-29 promotes the recruitment and activation of circulating monocytes and macrophages and, hence, inflammation, via miR-29 exosomes in a TRAF3-dependent manner. +circulation_biomarker_diagnosis_ns 33406428 hsa-mir-29 Diabetes Mellitus Mechanistically, our data show that miR-29 promotes the recruitment and activation of circulating monocytes and macrophages and, hence, inflammation, via miR-29 exosomes in a TRAF3-dependent manner. +transcription factor target 33406413 hsa-mir-194 Prostatic Neoplasms Overall, our study reveals a post-transcriptional mechanism regulating the plasticity of prostate cancer cells and provides a rationale for targeting miR-194 in NEPC. +lncRNA target 33406278 hsa-mir-650 Melanoma Collectively, ZFPM2-AS1 exerted an oncogenic role in cutaneous malignant melanoma progression via targeting miR-650/NOTCH1 signaling. +target gene 33405856 hsa-mir-21 Triple Negative Breast Neoplasms Folic-Acid-Adorned PEGylated Graphene Oxide Interferes with the Cell Migration of Triple Negative Breast Cancer Cell Line, MDAMB-231 by Targeting miR-21/PTEN Axis through NFκB. +other 33405047 hsa-mir-193a Autoimmune polyendocrinopathy syndrome, type 1 AIMS: The purpose of this study was to investigate the precise roles of miR-193a-5p and miR5p in AP. +other 33405047 hsa-mir-20 Autoimmune polyendocrinopathy syndrome, type 1 AIMS: The purpose of this study was to investigate the precise roles of miR-193a-5p and miR5p in AP. +circulation_biomarker_diagnosis_down 33405047 hsa-mir-193a Pancreatitis, Acute Necrotizing 5p were down-regulated in acute pancreatitis serum and caerulein-treated AR42J cells. +circulation_biomarker_diagnosis_down 33405047 hsa-mir-20 Pancreatitis, Acute Necrotizing 5p were down-regulated in acute pancreatitis serum and caerulein-treated AR42J cells. +lncRNA target 33405003 hsa-mir-219a Gestational Trophoblastic Disease CONCLUSIONS: These results revealed that miR-219a played crucial roles in negatively regulating trophoblastic proliferation and invasion by suppression of the PI3K/AKT/NF-kappaB signaling pathway by targeting VEGFR2, therefore serving as a potential treatment method for the complications of pregnancy caused by trophoblastic dysregulation. +lncRNA target 33404903 hsa-mir-671 Osteoarthritis Circ_0114876 targeted miR-671 to regulate cell progression and inflammation via modulating TRAF2 expression in IL-1beta induced CHON-001 cells, and played an important regulatory mechanism in IL-1beta-induced chondrocyte injury, providing a novel diagnostics and therapeutics in OA. +circulation_biomarker_diagnosis_up 33404840 hsa-mir-135b Cartilage Diseases Then, our results demonstrated that BMSCs-Exo(TGF-beta1) reduced OA-induced upregulation of pro-inflammatory factors in rat's serum and damage in cartilage tissues, which was then reversed by miR-135b decreasing. +other 33404569 hsa-mir-3 Non-alcoholic Fatty Liver Disease Collectively, our findings suggest that fructose-induced oxidative damage induces ferroptosis, and miR-33 could be used as a serological biomarker of fructose-induced NAFLD. +genetics_knock down_promote 33403756 hsa-mir-485 Breast Neoplasms CONCLUSION: Circ-DNMT1 knockdown constrains breast cancer development via modulating miR +circulation_biomarker_diagnosis_ns 33403596 hsa-mir-137 Schizophrenia In this regard, transcripts of brain-derived neurotrophic factor (BDNF) and four BDNF-associated lncRNAs (BDNF-AS, MIR137HG, MIAT, and PNKY) were evaluated in the peripheral blood of schizophrenia (SCZ) patients as well as normal subjects. BDNF, BDNF-AS, MIR137HG, and MIAT genes could discriminate SCZ patients from normal subjects with diagnostic power of 71%, 72%, 67%, and 68%, respectively. +lncRNA target 33403590 hsa-mir-23a Cerebral Hemorrhage Taken together, acupuncture may alleviate the neuronal cell death, inflammation, and ferroptosis after ICH by down-regulating miR-23a-3p. +lncRNA target 33403590 hsa-mir-23a Inflammation Taken together, acupuncture may alleviate the neuronal cell death, inflammation, and ferroptosis after ICH by down-regulating miR-23a-3p. +lncRNA target 33403590 hsa-mir-23a Thyroid Cancer, Papillary Taken together, acupuncture may alleviate the neuronal cell death, inflammation, and ferroptosis after ICH by down-regulating miR-23a-3p. +other 33403569 hsa-mir-144 Hypertension, Pulmonary PAT decreased miR-144 expression leading to NRF2 pathway activation and elevated AO gene expression. +other 33403483 hsa-mir-4253 esophagus adenocarcinoma miR-4253 and miR5p were associated with risk of mortality after EA diagnosis (HR = 4.85, 95% CI: 2.30-10.23, BH-adjusted P = 0.04 and HR = 3.81, 95% CI: 2.02-7.19, BH-adjusted P = 0.04, respectively). +lncRNA target 33403385 hsa-mir-193b Aortic Dissection RESULTS: LncRNA H19 was abnormally high-expressed in thoracic aorta tissues of AD patients, and it could competitively bind to and inhibit miR-193b-3p. +genetics_knock down_promote 33403035 hsa-mir-1254 Carcinoma, Hepatocellular Lentiviral-based overexpression and knockdown experiments indicated that miR-1254 promoted proliferation, migration, invasion, and the epithelial-mesenchymal transition of HCC cells. +genetics_GWAS 33402978 hsa-let-7 Lung Neoplasms Association of Rs61764370 polymorphism within let-7 microRNA-binding site with lung cancer in Iranian population. The aim of this study was to investigate the relationship between rs61764370 polymorphism within let-7 miRNA binding site in KRAS gene and the risk of lung cancer in Iranian population. +genetics_overexpression_suppress 33402977 hsa-mir-489 Carcinoma, Hepatocellular RESULTS: RT-PCR results showed that the cells compared with pre-cancerous tissue, the expression level of miR-489 in hepatocellular carcinoma tissues than in adjacent tissue significantly decreased (P<0.05), and with liver cancer cell metastasis increased (P<0.05); analogue transfection constructed miR-489 overexpressing HEPG2 cell line by microRNA. +circulation_biomarker_diagnosis_down 33402976 hsa-mir-451 Colorectal Neoplasms Serum miR-451 was significantly down-regulated in CRC patients (fold change = -4.86; p= 0.014), whereas, miR-23a was down-regulated but this was not statistically significant. +genetics_overexpression_promote 33402849 hsa-mir-196b Adenocarcinoma of Lung Overexpression of RSPO2 partially reversed the promotion of miR-196b-5p on proliferation, migration and invasion of LUAD cells. +lncRNA target 33402847 hsa-mir-204 Carcinoma, Non-Small-Cell Lung CONCLUSION: In summary, our results showed that the down-regulation of NEAT1 in NSCLC inhibited its growth, migration and invasion through the miR-204/NUAK1 axis. +lncRNA target 33402817 hsa-mir-185 Cardiomegaly DISCUSSION: Our data suggested that circHIPK3 serve as a miR3p sponge to regulate cardiac hypertrophy revealing a potential new target for the prevention of TAC- and Ang-II induced cardiac hypertrophy. +lncRNA target 33402731 hsa-mir-34a Osteoporosis Inhibited CCAT1 improved pathology and restricted osteocyte apoptosis of bone tissues in ovariectomized rats with osteoporosis in vivo, and also enhanced differentiation, mineralization abilities, and proliferation, and suppressed apoptosis of osteoblasts from ovariectomized rats in vitro through upregulating miR-34a-5p expression. +other 33402480 hsa-mir-146b Thyroid Cancer, Papillary MiR-146b, miR-187, miR-221 and miR-222 were also up-regulated in PTC compared to nodular goitre. +other 33402480 hsa-mir-221 Thyroid Cancer, Papillary MiR-146b, miR-187, miR-221 and miR-222 were also up-regulated in PTC compared to nodular goitre. +other 33402480 hsa-mir-187 Thyroid Cancer, Papillary MiR-146b, miR-187, miR-221 and miR-222 were also up-regulated in PTC compared to nodular goitre. +other 33402480 hsa-mir-222 Thyroid Cancer, Papillary MiR-146b, miR-187, miR-221 and miR-222 were also up-regulated in PTC compared to nodular goitre. +genetics_knock down_suppress 33402183 hsa-mir-210 Hypoxia-Ischemia, Brain Of importance, TET2 knockdown exacerbated brain infarct size and neurological deficits and counteracted the neuroprotective effect of miR-210 inhibition. +lncRNA target 33402177 hsa-mir-620 Neuroma, Acoustic CONCLUSIONS: HCG11 could inhibit the growth of VS by targeting miR-620/ELK4 in VS cells. +genetics_overexpression_suppress 33402109 hsa-mir-383 Stomach Neoplasms Overexpression of miR-383 downregulated Bcl-2, resulting in reduced survival of Fluorouracil-treated GC cells. +genetics_overexpression_suppress 33401967 hsa-mir-506 Liver Neoplasms 3p collaboratively caused a marked inhibition of liver cancer cell growth, migration and invasion, while the phenomena were neutralized by overexpression of SIRT1. +genetics_overexpression_suppress 33401967 hsa-mir-124 Liver Neoplasms 3p collaboratively caused a marked inhibition of liver cancer cell growth, migration and invasion, while the phenomena were neutralized by overexpression of SIRT1. +circulation_biomarker_diagnosis_down 33401931 hsa-mir-204 Diabetes Mellitus, Type 2 We investigated the association between plasma microRNA (miR)-204 and coronary artery calcification (CAC) in patients with type 2 diabetes mellitus (T2DM). In conclusion, the downregulation of miR-204 was independently associated with CAC in patients with T2DM. +circulation_biomarker_diagnosis_down 33401931 hsa-mir-204 Coronary Artery Disease We investigated the association between plasma microRNA (miR)-204 and coronary artery calcification (CAC) in patients with type 2 diabetes mellitus (T2DM). In conclusion, the downregulation of miR-204 was independently associated with CAC in patients with T2DM. +lncRNA target 33401249 hsa-mir-765 Carcinoma, Hepatocellular In conclusion, exo-linc-FAM138B secreted by cancer cells inhibited HCC development via targeting miR-765, which provided a new idea and perspective for in-depth understanding of the complex signal regulation in HCC process. +genetics_overexpression_promote 33400379 hsa-mir-495 Nasopharyngeal Carcinoma NPC cells were transfected with vectors overexpressing TP73-AS1, short hairpin RNA (shRNA) against TP73-AS1, shRNA against JAM-A, miR-495 mimics, miR-495 inhibitor, and their corresponding negative controls as designated. +lncRNA target 33400247 hsa-mir-497 Nasopharyngeal Carcinoma These results indicate that SP1-induced AFAP1-AS1 facilitates nasopharyngeal carcinoma progression by regulating miR5p/CELF1 pathway, which provides a new target for nasopharyngeal carcinoma treatment. +genetics_overexpression_promote 33400246 hsa-mir-106a Ovarian Neoplasms Also, the miR-106a overexpression reversed the inhibitory effects of XIST on OC cell proliferation and apoptosis. +genetics_overexpression_promote 33400245 hsa-mir-125b Urinary Bladder Neoplasms Moreover, overexpression of miR-125b-5p inhibited BC cell proliferation, migration, and invasion, while its effects were alleviated by overexpression of SphK1. +genetics_overexpression_promote 33400243 hsa-mir-675 Melanoma 3p was also overexpressed in the peripheral blood of melanoma patients relative to healthy controls, and in melanoma cell lines relative to control cells. +transcription factor target 33400022 hsa-mir-182 Endometriosis In a word, miR-182 directly targeted RELA and inhibited proliferation, migration, invasion, EMT and inflammation of endometrial stromal cells through deactivation of NF-B signaling pathway in endometriosis. +genetics_overexpression_suppress 33400021 hsa-mir-99a Pituitary Neoplasms Further experiments revealed that overexpressed miR-149 and miR-99a-3p inhibited the growth and metastasis of pituitary adenoma cells and tube formation of endothelial cells. +genetics_overexpression_suppress 33400021 hsa-mir-149 Pituitary Neoplasms Further experiments revealed that overexpressed miR-149 and miR-99a-3p inhibited the growth and metastasis of pituitary adenoma cells and tube formation of endothelial cells. +other 33399935 hsa-mir-21 Stomach Neoplasms Finally, the pooled prognostic result of miR-21 for hazard ratios (HR) was 1.260 (95% CI 0.370-4.330, P < 0.001), showing that miR-21 could predict poor survival in GC patients. +other 33399102 hsa-mir-4270 Carcinoma, Hepatocellular 5p, and miR-4270 might be significant for HCC development. +other 33399102 hsa-mir-3692 Carcinoma, Hepatocellular 5p, and miR-4270 might be significant for HCC development. +other 33399102 hsa-mir-25 Carcinoma, Hepatocellular 5p, and miR-4270 might be significant for HCC development. +lncRNA target 33398982 hsa-mir-146b Lung Carcinoid Down-regulated levels of miR3p and miR-146b-5p and target gene over-expression could play a role in the progression of this case of primary typical lung carcinoid to regional metastasis. +other 33398718 hsa-mir-376a Carcinoma, Hepatocellular CONCLUSIONS: ANXA2P1/miR-376a-3p/ANXA2 axis plays an important role in the progression of HCC. +other 33398678 hsa-mir-34 Colorectal Neoplasms In this study the level of the inflammatory cytokines including CXCL-12 (SDF-1), CCL-2 (MCP-1), TGF-beta and IL-33 has been measured in pmiR-34a-5p transfected and pmiR-34a-5p ZER treated CRC cell lines (HCT-116 and SW48) by QRT-PCR and ELISA methods, respectively. +other 33398678 hsa-mir-34a Colorectal Neoplasms In this study the level of the inflammatory cytokines including CXCL-12 (SDF-1), CCL-2 (MCP-1), TGF-beta and IL-33 has been measured in pmiR-34a-5p transfected and pmiR-34a-5p ZER treated CRC cell lines (HCT-116 and SW48) by QRT-PCR and ELISA methods, respectively. +lncRNA target 33398662 hsa-mir-452 Colorectal Neoplasms CONCLUSIONS: These results suggest that ASB8, NOL8, and CDR2 were target genes of MIR452 in CRC cells and that up-regulated MIR452 in CRC tissue regulated ASB8, NOL8, and CDR2 expression during colorectal carcinogenesis. +lncRNA target 33398465 hsa-mir-758 Uterine Cervical Neoplasms CircRBM33 fostered CC advancement via absorbing miR +lncRNA target 33398455 hsa-mir-29b Diabetic Cardiomyopathies CONCLUSIONS/INTERPRETATION: circHIPK3 contributes to increased myocardial fibrosis during DCM by functioning as a competing endogenous RNA that upregulates Col1a1 and Col3a1 expression through suppressing miR-29b-3p. +genetics_overexpression_suppress 33398379 hsa-mir-503 Carcinoma, Hepatocellular Furthermore, overexpression of NEAT1 or SMO could reverse the effects of miR503mediated inhibition on cell viability, invasion, migration and promotion of apoptosis in the HCC cell lines. +other 33398378 hsa-mir-130a Myocardial Reperfusion Injury Differential lncRNAs in myocardial ischemia rats were screened by a lncRNA microarray and the expression levels of lncRNA HOTAIR and microRNA (miR)130a3p were analyzed using reverse transcriptionquantitative polymerase chain reaction in hypoxiainduced cardiomyocytes. +genetics_overexpression_suppress 33398375 hsa-mir-613 Granulomatosis with Polyangiitis The overexpression of IGF-1 attenuated the inhibitory effects of miR-613 on cell cycle arrest, cyclin D1 and CDK1 expression, and the proliferation of KGN cells. +lncRNA target 33398375 hsa-mir-613 Polycystic Ovary Syndrome The aim of the present study was to elucidate the regulatory effects of miR-613 and insulin-like growth factor-1 (IGF-1) on the pathological process of polycystic ovary syndrome (PCOS). Therefore, it is suggested that miR-613 and IGF-1 could potentially be diagnostic biomarkers and therapeutic targets for PCOS. +transcription factor target 33398374 hsa-mir-34a Colorectal Neoplasms Compared with the control group, melatonin significantly enhanced the expression levels of the miR34a/449a cluster, reduced CRC cell proliferation and viability, and increased CRC cell apoptosis. To the best of our knowledge, the present study was the first to suggest that melatonin inhibited proliferation and viability, and promoted apoptosis in CRC cells via upregulating the expression of the miR34a/449a cluster in vitro and in vivo. +genetics_overexpression_promote 33398370 hsa-mir-149 Squamous Cell Carcinoma of Head and Neck In the present study, overexpression of miR1493p reduced the viability and proliferation of OSCC cells. +other 33397596 hsa-mir-141 Prostatic Neoplasms As a proof-of-principle, a wide range of probes were designed and tested to detect miR-141, a known diagnostic biomarker for prostate cancer. +genetics_overexpression_suppress 33397320 hsa-mir-200c Colonic Neoplasms This study aimed to investigate the mechanism of miR-200c targets fucosyltransferase 4 (FUT4) on the proliferation of colon cancer. CONCLUSIONS: In summary, miR-200c overexpression inhibits proliferation of colon cancer targeting FUT4 to downregulate the Wnt/beta-catenin pathway, which promises molecular targets to inhibit metastasis for colon cancer therapy. +circulation_biomarker_diagnosis_ns 33397284 hsa-mir-193b Trachoma trachomatis development, miR-193b-5p, showed significant expression in clinical serum samples of C. +other 33396699 hsa-mir-181a Lupus Nephritis There were lower miR-181a levels in LN mononuclear cells, negatively correlated with activity. +lncRNA target 33396625 hsa-mir-34c Triple Negative Breast Neoplasms In this study, we evaluated AdoMet-induced modulation of miRNA-34c and miRNA-449a expression in MDA-MB-231 and MDA-MB-468 TNBC cells. Our results furnished the first evidence that AdoMet exerts its antitumor effects in TNBC cells through upregulating the expression of miR-34c and miR-449a. +lncRNA target 33396625 hsa-mir-449a Triple Negative Breast Neoplasms In this study, we evaluated AdoMet-induced modulation of miRNA-34c and miRNA-449a expression in MDA-MB-231 and MDA-MB-468 TNBC cells. Our results furnished the first evidence that AdoMet exerts its antitumor effects in TNBC cells through upregulating the expression of miR-34c and miR-449a. +other 33396613 hsa-mir-146a Thyroid Cancer, Papillary VEGFA and PGF mRNA and protein, as well as the angiomiRNAs miR-146a-3p and miR5p were upregulated as IL-36 response in PTC and HTR-8/SVneo cells. +lncRNA target 33396457 hsa-mir-200c Glioblastoma We investigated the effect of miR-200c on ZEB1 expression and cell migration in an in vitro transfection model with a miR-200c mimic, a miR-200c inhibitor and siRNA targeting EGFR in three short-term cultures with different levels of EGFR amplification obtained from resected glioblastomas. Our results suggest that modulating miR-200c may serve as a novel therapeutic approach for glioblastoma depending on EGFR status. +lncRNA target 33395681 hsa-mir-155 Osteoarthritis CONCLUSIONS: Taken together, our data suggest tanshinone IIA ameliorates inflammation response in OA via inhibition of the miR-155/FOXO3 axis, and provide some evidences that tanshinone IIA could be designed and developed as a new promising clinical therapeutic drug for OA patients. +genetics_knock down_suppress 33395541 hsa-mir-515 Carcinoma, Non-Small-Cell Lung Long Noncoding RNA MALAT1 Knockdown Inhibits Proliferation, Migration, and Invasion and Promotes Apoptosis in Non-Small-Cell Lung Cancer Cells Through Regulating miR-515-3p/TRIM65 Axis. +transcription factor target 33395357 hsa-mir-181a Myocardial Infarction The network demonstrated three MI-associated miRNAs, miR-498, miR-181a, and miR-612, and 45 novel target genes, as well as their interaction involved in MI. In conclusion, miR-498, miR-181a, and miR-612 may participate in the pathogenesis of MI and may serve as the potential therapeutic targets or biomarkers. +transcription factor target 33395357 hsa-mir-612 Myocardial Infarction The network demonstrated three MI-associated miRNAs, miR-498, miR-181a, and miR-612, and 45 novel target genes, as well as their interaction involved in MI. In conclusion, miR-498, miR-181a, and miR-612 may participate in the pathogenesis of MI and may serve as the potential therapeutic targets or biomarkers. +transcription factor target 33395357 hsa-mir-498 Myocardial Infarction The network demonstrated three MI-associated miRNAs, miR-498, miR-181a, and miR-612, and 45 novel target genes, as well as their interaction involved in MI. In conclusion, miR-498, miR-181a, and miR-612 may participate in the pathogenesis of MI and may serve as the potential therapeutic targets or biomarkers. +transcription factor target 33395188 hsa-mir-130a Neuralgia Besides, tail vein injection of miR-130a-5p mimics inhibited the activation and inflammatory response of astrocytes, thus alleviating chronic constriction injury-induced neuropathic pain. +genetics_overexpression_promote 33395185 hsa-mir-522 Glioblastoma 3p was overexpressed in glioblastoma tissues compared with that in normal tissues, and the inhibition of miR +other 33394826 hsa-mir-21 Reperfusion Injury A specific anti-miR-21 has emerged as an effective treatment for ischemia/reperfusion injury in a pig model of myocardial infarction (MI), but the perspectives for clinical translation are limited. Anti-miR-21 blunts profibrotic pathways, whose excessive activation is detrimental in the post-MI setting. +other 33394826 hsa-mir-21 Myocardial Infarction A specific anti-miR-21 has emerged as an effective treatment for ischemia/reperfusion injury in a pig model of myocardial infarction (MI), but the perspectives for clinical translation are limited. Anti-miR-21 blunts profibrotic pathways, whose excessive activation is detrimental in the post-MI setting. +transcription factor target 33394350 hsa-mir-542 Heart Diseases The current data suggest that miR5p/autophagy pathway might be a potential target for the treatment of H/R-related heart diseases. +transcription factor target 33394350 hsa-mir-542 Reinjuries 5p inhibitor in alleviating H/R injury. +transcription factor target 33394350 hsa-mir-542 Anodontia 5p inhibitor in alleviating H/R injury. +genetics_knock down_promote 33394349 hsa-mir-204 Arthritis, Rheumatoid Meanwhile, Knockdown of NEAT1 attenuated TNF-alpha-induced RA-FLSs cell proliferation and inflammatory cytokine production while promoted cell apoptosis by targeting miR +lncRNA target 33394312 hsa-mir-21 Pulmonary Arterial Hypertension Collectively, we provided evidence that simvastatin can protect ATPase activity and maintain myocardial ATP energy reserve through the miR5p/Smad/TGF-beta axis, thus ameliorating PAH induced RHF. +lncRNA target 33394312 hsa-mir-21 Heart Failure Collectively, we provided evidence that simvastatin can protect ATPase activity and maintain myocardial ATP energy reserve through the miR5p/Smad/TGF-beta axis, thus ameliorating PAH induced RHF. +lncRNA target 33394311 hsa-mir-218 Inflammation Up-regulation of circ_0045714 suppressed TNF-alpha-induced chondrocyte growth inhibition, inflammation, and ECM degradation via miR5p/HRAS axis, suggesting a novel insight into the pathogenesis of OA and the potential protective role of circ_0045714 in the occurrence and development of OA. +lncRNA target 33394311 hsa-mir-218 Osteoarthritis Up-regulation of circ_0045714 suppressed TNF-alpha-induced chondrocyte growth inhibition, inflammation, and ECM degradation via miR5p/HRAS axis, suggesting a novel insight into the pathogenesis of OA and the potential protective role of circ_0045714 in the occurrence and development of OA. +other 33394293 hsa-mir-214 Uterine Cervical Neoplasms 5p to regulate the expression of SEMA4C, and further regulate invasion and hypoxia-glycolysis in CC cells. +genetics_knock down_promote 33394291 hsa-mir-216b Colorectal Neoplasms MiR-216b-5p bound to the 3' untranslated region (3'UTR) of ZNF146, and ZNF146 overexpression partly attenuated miR-216b-5p overexpression-mediated influences in CRC cells. +genetics_overexpression_promote 33394187 hsa-mir-98 Inflammatory Bowel Diseases LncRNA MEG3 overexpression alleviates the serve ulceration of UC rat colons by upregulating IL-10 expression via sponging miR +genetics_overexpression_promote 33394172 hsa-mir-296 Porcine Reproductive and Respiratory Syndrome Notably, the overexpression of miR +circRNA target 33393621 hsa-mir-194 psoriasis 1 induced proliferation and metastasis in HaCaT cells through enhancing GAB1 expression via sponging miR +genetics_knock down_promote 33393590 hsa-mir-98 Glioma NEAT1 knockdown inhibited glioma cell proliferation in vivo via miR +circulation_biomarker_prognosis_up 33393369 hsa-mir-600 Breast Neoplasms Materials & methods: The expression of miR-600 and WT1 in tumor and non-tumor adjacent tissues in 45 breast cancer patients as well as serum level of miR-600 in these patients and 45 healthy group were analyzed. +genetics_overexpression_suppress 33393324 hsa-mir-145 Sarcoma, Ewing The miR-145 overexpression caused inhibition of proliferation and reduced migration in EWS cells through induction of apoptosis. +other 33393045 hsa-mir-593 Pancreatic Carcinoma 3p could be a useful prognostic predictor for pancreatic cancer patients undergoing staging laparoscopy. +lncRNA target 33392891 hsa-mir-217 Aging, Premature In addition, SA-beta-gal staining detected the effects of miR-217 inhibitor and SIRT1 on senescent HUVECs. +circulation_biomarker_diagnosis_ns 33392483 hsa-mir-126 Kidney Diseases We measured circulating miR-126 in rats with nephrotoxic nephritis (NTN) and humans with acute endothelial and renal injury (vasculitis associated with autoantibodies to neutrophil cytoplasm antigens (ANCAs)). +other 33392188 hsa-mir-7 Brain Edema 5p, affecting these pathways to reduce brain edema. +other 33392188 hsa-mir-7 Cerebral Hemorrhage 5p, affecting these pathways to reduce brain edema. +genetics_knock down_suppress 33392180 hsa-mir-217 Esophageal Squamous Cell Carcinoma Knockdown of circ-ZDHHC5 inhibited tumorigenesis in ESCC cells, and the co-transfection of si-circ-ZDHHC5 and miR-217 mimics further enhanced the above effect. +transcription factor target 33392159 hsa-mir-1248 Premature Birth Moreover, 6 regulatory pairs, including hsa-MORC3_0001-hsa-miRCHRM2 were the core parts of this mechanism network, which might be therapeutic targets for PTB. +target gene 33392094 hsa-mir-18a Ovarian Neoplasms MicroRNA-18a-5p Suppresses Tumor Growth via Targeting Matrix Metalloproteinase-3 in Cisplatin-Resistant Ovarian Cancer. +other 33392070 hsa-mir-124 Colitis-Associated Neoplasms CONCLUSIONS: Our study strengthened the important role of miR-124 in the regulation of adaptive immune responses and blocking the development of colitis-related cancer. +circulation_biomarker_diagnosis_ns 33391543 hsa-mir-21 Breast Neoplasms Moreover, miR-21 level in serum exosomes of breast cancer patients with bone metastasis is significantly higher than that in other subpopulations. +genetics_knock down_promote 33391532 hsa-mir-124 Ischemic Stroke Results: M2 microglial small extracellular vesicles reduced glial scar formation and promoted recovery after stroke and were enriched in miR-124. Finally, miR-124 knockdown in M2 microglial small extracellular vesicles blocked their effects on glial scars and stroke recovery. +genetics_knock down_promote 33391532 hsa-mir-124 Stroke Results: M2 microglial small extracellular vesicles reduced glial scar formation and promoted recovery after stroke and were enriched in miR-124. Finally, miR-124 knockdown in M2 microglial small extracellular vesicles blocked their effects on glial scars and stroke recovery. +other 33391522 hsa-mir-802 Obesity Collectively: Our study reveals the significant role of miR-802/AMPK axis in hepatic lipid metabolism and identifies the therapeutic potential of Sjp40 in treating obesity-related fatty liver. +circulation_biomarker_diagnosis_up 33391510 hsa-mir-181a Prostatic Neoplasms Conclusion: EV-delivered miR-181a-5p from patient's serum is a promising diagnostic biomarker for bone metastatic prostate cancer. +target gene 33391456 hsa-mir-149 Ovarian Neoplasms Circular PVT1 regulates cell proliferation and invasion via miR-149-5p/FOXM1 axis in ovarian cancer. +target gene 33391417 hsa-mir-145 Ovarian Neoplasms Berberine inhibits the Warburg effect through TET3/miR-145/HK2 pathways in ovarian cancer cells. +genetics_knock down_promote 33391404 hsa-mir-17 Triple Negative Breast Neoplasms Shikonin inhibits migration and invasion of triple-negative breast cancer cells by suppressing epithelial-mesenchymal transition via miR-17-5p/PTEN/Akt pathway. +other 33391354 hsa-mir-29c Urinary Bladder Neoplasms RESULTS: A total of eight elements in the ceRNA network were considered as key members and correlated with the prognosis of BLCA, including ELN, SREBF1, DSC2, TTLL7, DIP2C, SATB1, hsa-miR-20a-5p, and hsa-miR-29c-3p. CONCLUSION: Our results suggest that the mechanism of hsa-miR-29c-3p regulates the expression of ELN and DSC2, and the infiltration of Tfh and neutrophils might play pivotal roles in the progression of BLCA. +other 33391341 hsa-mir-3156 Periodontitis differentially expressed +other 33391341 hsa-mir-3917 Periodontitis differentially expressed +other 33391341 hsa-mir-203a Periodontitis hsa-miR-203a-5p differentially expressed +other 33391341 hsa-mir-145 Periodontitis hsa-miR-145-3p differentially expressed +other 33391341 hsa-mir-125a Periodontitis hsa-miR-125a-5p differentially expressed +other 33391341 hsa-mir-4271 Periodontitis differentially expressed +other 33391341 hsa-mir-671 Periodontitis hsa-miR-671-5p differentially expressed +other 33391341 hsa-mir-204 Periodontitis hsa-miR-204-3p differentially expressed +other 33391341 hsa-mir-650 Periodontitis differentially expressed +virus_miRNA 33391341 hcmv-mir-UL70 Periodontitis differentially expressed +other 33391341 hsa-mir-1246 Periodontitis differentially expressed +other 33391341 hsa-mir-141 Periodontitis hsa-miR-141-3p differentially expressed +other 33391341 hsa-mir-497 Periodontitis hsa-miR-497-3p differentially expressed +other 33391341 hsa-mir-99a Periodontitis hsa-miR-99a-3p differentially expressed +transcription factor target 33391256 hsa-mir-155 aortic atherosclerosis uEVs from patients with unstable CAD had increased expression of miR-155 in comparison to patients with stable CAD. CONCLUSION: miR-155 suppresses anti-inflammatory signaling in macrophages, is decreased during regression of atherosclerosis in vivo and is increased in uEVs from patients with unstable CAD suggesting miR-155 has potential as a prognostic indicator and a therapeutic target. +target gene 33390953 hsa-mir-138 Stomach Neoplasms Bruceine D inhibits Cell Proliferation Through Downregulating LINC01667/MicroRNA-138-5p/Cyclin E1 Axis in Gastric Cancer. +lncRNA target 33390802 hsa-mir-5589 Carcinoma, Hepatocellular 3p/CCNB1 and hsa-let-7c-3p/CKS2 might serve as potential prognostic biomarkers and therapeutic targets for HBV-related HCC. +lncRNA target 33390783 hsa-mir-125b Carcinoma, Renal Cell MiR-125B may be a potential therapeutic target for RCC. +tissue_expression_ns 33390770 hsa-mir-216b Cardiomegaly NPY inactivation increased miR-216b and decreased FoxO4 expression in CH heart. Collectively, NPY deficiency attenuated CH by NPY1R-miR-216b-FoxO4 axis. +lncRNA target 33390476 hsa-mir-96 Neurodegenerative Diseases 5p inhibitor suppresses the onset or slows the progression of neurodegenerative diseases by increasing EAAC1 levels leading to promoting neuronal GSH production. +other 33390186 hsa-mir-212 Atrial Premature Complexes 5p/miR-449a and E2F5 is responsible for PCa development. +other 33390186 hsa-mir-449a Atrial Premature Complexes CONCLUSIONS: These findings suggest that CDK13 upregulation-induced formation of the positive feedback loop among circCDK13, miR5p/miR-449a and E2F5 is responsible for PCa development. +other 33389830 hsa-mir-125b Exfoliation Syndrome There are 2 possible interpretations of these results: either the co-existence of PEX acts as a moderator of miR-125b expression in the anterior lens capsule, or increased expression of miR-125b can play a role in the pathogenesis of PEX. +genetics_overexpression_promote 33389611 hsa-mir-520d Cardiomyopathy, Hypertrophic Our result indicated that overexpression of microRNA-520d-3p attenuated the effect of H/R treatments on cell viability, apoptosis and autophagy, through partly regulating ATG12 expression in HCM. +genetics_knock down_promote 33389570 hsa-mir-526b Glioma Finally, knockdown of LINC00689 inhibited the tumor growth of glioma in vivo through regulating miR-526b-3p/IGF2BP1/MAPK axis. +genetics_overexpression_promote 33389496 hsa-mir-23a Melanoma In present study, GINS2 and lncRNA XIST were overexpressed in melanoma, while miR-23a-3p was downregulated. LncRNA XIST significantly promoted the tumorigenesis of melanoma via sponging miR-23a-3p and indirectly targeting GINS2, which can be a potential new target for treating melanoma. +genetics_overexpression_suppress 33389493 hsa-mir-769 Keloid 5p overexpression on keloid formation. +other 33389428 hsa-mir-181a Parkinson Disease We demonstrated that SNHG1 promoted MPP(+) induced neuronal injury in neuroblastoma cells by regulating miR-181a-5p/CXCL12 axis, suggesting SNHG1 might contribute to the development of PD, which provided a novel insight into the pathogenesis and treatment of PD. +genetics_knock down_suppress 33389349 hsa-mir-224 Stomach Neoplasms 5p could restore the inhibitive influence of circ-LDLRAD3 knockdown on the progression of GC. +genetics_knock down_suppress 33389283 hsa-mir-590 Colorectal Neoplasms Knockdown of FTX or overexpression of miR +other 33389245 hsa-mir-153 Epilepsy, Temporal Lobe However, only three studies robustly investigated microRNAs as potential biomarkers in the diagnosis of drug-resistant TLE (microRNA-155 (upregulated), microRNA2-3p (upregulated), microRNA-153 (downregulated)). +other 33389245 hsa-mir-155 Epilepsy, Temporal Lobe However, only three studies robustly investigated microRNAs as potential biomarkers in the diagnosis of drug-resistant TLE (microRNA-155 (upregulated), microRNA2-3p (upregulated), microRNA-153 (downregulated)). +other 33389245 hsa-mir-129 Epilepsy, Temporal Lobe However, only three studies robustly investigated microRNAs as potential biomarkers in the diagnosis of drug-resistant TLE (microRNA-155 (upregulated), microRNA2-3p (upregulated), microRNA-153 (downregulated)). +circulation_biomarker_diagnosis_ns 33389220 hsa-mir-4446 Arthritis, Rheumatoid Key Point * A plasma microRNA panel including let-7c-5p, miR-30a-5p, miR-30e-5p, miR-125a-5p, miR +circulation_biomarker_diagnosis_ns 33389220 hsa-let-7c Atherosclerosis Key Point * A plasma microRNA panel including let-7c-5p, miR-30a-5p, miR-30e-5p, miR-125a-5p, miR +circulation_biomarker_diagnosis_ns 33389220 hsa-mir-125a Arthritis, Rheumatoid Key Point * A plasma microRNA panel including let-7c-5p, miR-30a-5p, miR-30e-5p, miR-125a-5p, miR +circulation_biomarker_diagnosis_ns 33389220 hsa-mir-4446 Atherosclerosis Key Point * A plasma microRNA panel including let-7c-5p, miR-30a-5p, miR-30e-5p, miR-125a-5p, miR +circulation_biomarker_diagnosis_ns 33389220 hsa-mir-3168 Atherosclerosis Key Point * A plasma microRNA panel including let-7c-5p, miR-30a-5p, miR-30e-5p, miR-125a-5p, miR +circulation_biomarker_diagnosis_ns 33389220 hsa-mir-425 Arthritis, Rheumatoid Key Point * A plasma microRNA panel including let-7c-5p, miR-30a-5p, miR-30e-5p, miR-125a-5p, miR +circulation_biomarker_diagnosis_ns 33389220 hsa-mir-3168 Arthritis, Rheumatoid Key Point * A plasma microRNA panel including let-7c-5p, miR-30a-5p, miR-30e-5p, miR-125a-5p, miR +circulation_biomarker_diagnosis_ns 33389220 hsa-mir-425 Atherosclerosis Key Point * A plasma microRNA panel including let-7c-5p, miR-30a-5p, miR-30e-5p, miR-125a-5p, miR +circulation_biomarker_diagnosis_ns 33389220 hsa-mir-125a Atherosclerosis Key Point * A plasma microRNA panel including let-7c-5p, miR-30a-5p, miR-30e-5p, miR-125a-5p, miR +circulation_biomarker_diagnosis_ns 33389220 hsa-mir-126 Arthritis, Rheumatoid Key Point * A plasma microRNA panel including let-7c-5p, miR-30a-5p, miR-30e-5p, miR-125a-5p, miR +circulation_biomarker_diagnosis_ns 33389220 hsa-mir-126 Atherosclerosis Key Point * A plasma microRNA panel including let-7c-5p, miR-30a-5p, miR-30e-5p, miR-125a-5p, miR +circulation_biomarker_diagnosis_ns 33389220 hsa-let-7c Arthritis, Rheumatoid Key Point * A plasma microRNA panel including let-7c-5p, miR-30a-5p, miR-30e-5p, miR-125a-5p, miR +epigenetics 33388023 hsa-mir-9-1 Diabetic Retinopathy CONCLUSION: Our results suggest that both methylation of miR +epigenetics 33388023 hsa-mir-9 Diabetic Retinopathy CONCLUSION: Our results suggest that both methylation of miR +other 33387827 hsa-mir-124 Adenomyosis 3p was down-regulated and NRP1 was up-regulated in AM eutopic endometrial tissues. +genetics_overexpression_promote 33387246 hsa-mir-596 Prostatic Neoplasms CONCLUSIONS: In summary, this research indicates that miR-596 overexpression could be potentially useful in the cell growth and migration of prostatic cancer and serves as a potential molecular marker in prostatic cancer. +lncRNA target 33387208 hsa-mir-133a Cervical Intraepithelial Neoplasia However, the molecular mechanism of XIST and its relation with miR-133a-3p in contrast-induced nephropathy (CIN) remained vague. Moreover, downregulating XIST attenuated CIN injury via regulating miR-133a-3p/NLRP3 axis. +other 33387208 hsa-mir-133a Kidney Diseases However, the molecular mechanism of XIST and its relation with miR-133a-3p in contrast-induced nephropathy (CIN) remained vague. +lncRNA target 33387127 hsa-mir-134 Carcinoma, Hepatocellular CONCLUSION: The current study provided evidence that TTN-AS1 might promote HCC progression through sponging miR-134 and the following ITGB1 up-regulation. +genetics_overexpression_promote 33386874 hsa-mir-125b Sepsis CONCLUSION: Our study indicates that ECs-derived exosomes overexpressed miR-125b-5p to protect from sepsis-induced ALI by inhibiting TOP2A, which may contribute to ALI therapeutic strategies. +genetics_overexpression_promote 33386874 hsa-mir-125b Acute Lung Injury CONCLUSION: Our study indicates that ECs-derived exosomes overexpressed miR-125b-5p to protect from sepsis-induced ALI by inhibiting TOP2A, which may contribute to ALI therapeutic strategies. +other 33386794 hsa-mir-137 Colorectal Neoplasms CONCLUSIONS: LncRNA XIST/miR-137 axis reinforced glycolysis and chemo-tolerance of CRC by elevating PKM2/PKM1 ratio, providing an alternative to boost chemo-therapeutic efficacy of CRC patients. +genetics_knock down_suppress 33386518 hsa-mir-1297 Stomach Neoplasms Overexpression of E2F3 could invert the inhibitory effect of miR-1297 on GC progression. +genetics_overexpression_promote 33386495 hsa-mir-1270 Uterine Cervical Neoplasms Compared with that in adjacent tissues and normal cervical epithelial cells, circ_0001247 expression in CC tissues and cell lines was significantly increased; knocking down circ_0001247 expression could inhibit the proliferation and metastasis of CC cells, and promote apoptosis, while circ_0001247 overexpression worked oppositely; circ_0001247 sponged miR-1270 in CC cells; miR-1270 diminished the promoting effect of circ_0001247 by inactivating the ZEB2. +epigenetics 33386469 hsa-mir-217 Urinary Bladder Neoplasms CONCLUSION: CircRNA-100284 activates aurora kinase B by inducing methylation of HSP70 via microRNA-217 to promote the proliferation of bladder cancer cells. +other 33385494 hsa-mir-124 Femur Head Necrosis 3p, miR-125a-3p, and Ctnnb1 were important members of SINFH dysfunction. +other 33385494 hsa-mir-22 Femur Head Necrosis 3p, miR-125a-3p, and Ctnnb1 were important members of SINFH dysfunction. +other 33385494 hsa-mir-125a Femur Head Necrosis 3p, miR-125a-3p, and Ctnnb1 were important members of SINFH dysfunction. +transcription factor target 33385444 hsa-mir-145 Pulmonary Disease, Chronic Obstructive In a comparison of the normal and the most severe group (ie, normal growth compared with RGED), we found 1 strongly dysregulated miRNA, hsa-miR +genetics_knock down_promote 33385416 hsa-mir-21 Diabetic Cardiomyopathies Gain-of-function and loss-of-function assays demonstrated that miR +genetics_overexpression_promote 33385377 hsa-mir-194 Cerebral Hemorrhage Collectively, overexpression of miR +genetics_knock down_suppress 33385064 hsa-mir-16 Breast Neoplasms CONCLUSION: ATXN8OS knockdown enhanced BC TAMR sensitivity partially through the miR +transcription factor target 33385002 hsa-mir-106a Squamous Cell Carcinoma of Head and Neck Conclusions: Our study indicated that HPV E7 activated DGCR8/miR-106a/RUNX3 axis to enhance radiation sensitivity and provided directions for targeted therapeutic interventions. +lncRNA target 33384174 hsa-mir-218 Neurotic Disorders Our previous work shows that the microRNA miR-218 mediates susceptibility to stress and depression in adulthood by targeting the netrin-1 guidance cue receptor gene Dcc in the medial prefrontal cortex (mPFC). +genetics_GWAS 33383878 hsa-let-7a Thyroid Cancer, Papillary Conclusion: Data in this study indicated that the changes of epigenetic molecules including DNMT1, DNMT3a, DNMT3b, HDAC1, and let-7a occurred at the early stages of BEAS-2B cell malignant transformation after CTPE exposure, which provided critical information for screening early biomarkers of CTP-associated occupational lung cancer. +genetics_GWAS 33383878 hsa-let-7a Lung Neoplasms Conclusion: Data in this study indicated that the changes of epigenetic molecules including DNMT1, DNMT3a, DNMT3b, HDAC1, and let-7a occurred at the early stages of BEAS-2B cell malignant transformation after CTPE exposure, which provided critical information for screening early biomarkers of CTP-associated occupational lung cancer. +circRNA target 33383027 hsa-mir-9 Cataract, Age-Related Hsa_circRNA7329 may regulate SCD through hsa-miR-9 to promote macrophage-mediated inflammation and pathologic angiogenesis, which lead to AMD development. +circulation_biomarker_prognosis_down 33382770 hsa-mir-223 Neuroendocrine Tumors CONCLUSION: Lower concentrations of circulating miR-223 rather reflect the presence of NET itself than certain tumor characteristics. +genetics_overexpression_promote 33382472 hsa-mir-141 Tuberous Sclerosis 3p, which functions as an oncogene in multiple malignancies, has been shown to be highly overexpressed in esophageal cancer cells in our previous work. +genetics_overexpression_promote 33382472 hsa-mir-141 Esophageal Squamous Cell Carcinoma 3p, which functions as an oncogene in multiple malignancies, has been shown to be highly overexpressed in esophageal cancer cells in our previous work. +other 33382217 hsa-mir-195 Prostatic Neoplasms OBJECTIVE: To investigate the regulatory effect of the transcription factor NF-kB1 on the expression of miR-195 in prostate cancer (PCa). CONCLUSIONS: NF-kB1 regulates the expression of miR-195 in prostate cancer. +genetics_knock down_suppress 33382158 hsa-mir-149 Squamous Cell Carcinoma of Head and Neck CONCLUSION: circBICD2 knockdown repressed OSCC cell proliferation, migration, invasion, and glutaminolysis and increased apoptosis via modulating miR +other 33382073 hsa-mir-431 Cardiomyopathies However, the role of miR-431 remains unclear in myocardial injury. +lncRNA target 33382018 hsa-mir-146a Leukemia, Myeloid, Acute CONCLUSIONS: Our results showed that MALAT1 regulates migration, proliferation and apoptosis by sponging miR-146a to regulate CXCR4 expression in AML cells, providing novel insights into the role of MALAT1 as a therapeutic target in AML. +lncRNA target 33381597 hsa-mir-361 Carcinoma, Hepatocellular 5p inhibits tumorigenesis and EMT in HCC by targeting Twist1. +genetics_overexpression_promote 33381563 hsa-mir-187 Osteoporosis-pseudoglioma syndrome Moreover, overexpression of miR5p suppressed osteoblastic differentiation of BMSCs through increasing alkaline phosphatase (ALP), matrix mineralization, and levels of Osterix (OSX), and osteopontin (OPN) as well as runt-related transcription factor 2 (Runx2) in vitro. +transcription factor target 33381563 hsa-mir-187 Bone Diseases, Metabolic Taken together, our results suggested for the first time that miR5p may promote osteogenesis by targeting ICAM-1, and provided a possible therapeutic target for bone metabolic diseases. +circulation_biomarker_diagnosis_up 33381550 hsa-mir-149 Coronary Artery Disease In conclusion, our findings suggest that serum exosomal miR +circulation_biomarker_diagnosis_up 33381550 hsa-mir-148b Coronary Artery Disease 5p, were quantified in circulating exosomes from the control group (n = 20) and the SCAD group (n = 20) by quantitative real-time polymerase chain reaction (qPCR). +circulation_biomarker_diagnosis_up 33381550 hsa-mir-32 Coronary Artery Disease In conclusion, our findings suggest that serum exosomal miR +circulation_biomarker_diagnosis_up 33381550 hsa-mir-192 Coronary Artery Disease 5p, were quantified in circulating exosomes from the control group (n = 20) and the SCAD group (n = 20) by quantitative real-time polymerase chain reaction (qPCR). +circulation_biomarker_diagnosis_up 33381550 hsa-mir-942 Coronary Artery Disease In conclusion, our findings suggest that serum exosomal miR +circulation_biomarker_diagnosis_up 33381550 hsa-mir-125a Coronary Artery Disease 5p, were quantified in circulating exosomes from the control group (n = 20) and the SCAD group (n = 20) by quantitative real-time polymerase chain reaction (qPCR). +other 33381243 hsa-mir-230a Hyperparathyroidism, Neonatal Severe Primary CONCLUSION: To conclude, three miRNAs (i.e., miR-210, miR-230a, and miR-23b) were identified to be crosstalks linking the interaction between ECs and NSPCs by implicating in both angiogenesis and neurogenesis. +other 33381243 hsa-mir-23b Hyperparathyroidism, Neonatal Severe Primary CONCLUSION: To conclude, three miRNAs (i.e., miR-210, miR-230a, and miR-23b) were identified to be crosstalks linking the interaction between ECs and NSPCs by implicating in both angiogenesis and neurogenesis. +other 33381243 hsa-mir-210 Hyperparathyroidism, Neonatal Severe Primary CONCLUSION: To conclude, three miRNAs (i.e., miR-210, miR-230a, and miR-23b) were identified to be crosstalks linking the interaction between ECs and NSPCs by implicating in both angiogenesis and neurogenesis. +other 33381152 hsa-mir-144 Diabetes Mellitus, Type 2 miR-144 is significantly upregulated in type II diabetes (T2D), and is considered to be an important biomarker for T2D. However, although the occurrence of T2D is inextricably linked to adipogenesis, whether miR-144 directly regulates adipogenesis remains to be further explored. +lncRNA target 33381046 hsa-mir-3 Inflammation Collectively, TFA can attenuate atherosclerosis via dual suppression of miR-33 and NFkappaB pathway, and partially through inhibition of scavenger receptors in macrophage. +lncRNA target 33381046 hsa-mir-3 Atherosclerosis Collectively, TFA can attenuate atherosclerosis via dual suppression of miR-33 and NFkappaB pathway, and partially through inhibition of scavenger receptors in macrophage. +lncRNA target 33381046 hsa-mir-3 Lipid Metabolism Disorders Collectively, TFA can attenuate atherosclerosis via dual suppression of miR-33 and NFkappaB pathway, and partially through inhibition of scavenger receptors in macrophage. +lncRNA target 33381046 hsa-mir-3 Non-alcoholic Fatty Liver Disease Collectively, TFA can attenuate atherosclerosis via dual suppression of miR-33 and NFkappaB pathway, and partially through inhibition of scavenger receptors in macrophage. +other 33381022 hsa-mir-433 Nerve Degeneration Many aspects underlying the mechanism of miR-433 in neural development and neurodegeneration are not clear. +other 33381022 hsa-mir-433 Neurodegenerative Diseases miR-433 may play a regulatory role in neurodegenerative diseases. +lncRNA target 33380840 hsa-mir-214 Carcinoma, Renal Cell Mechanically, HCP5 inhibited the growth and metastasis of ccRCC cells by regulating miR +target gene 33380838 hsa-mir-548d Stomach Neoplasms MiR-548d-3p Promotes Gastric Cancer by Targeting RSK4. +genetics_knock down_suppress 33380835 hsa-mir-206 Leukemia, Myeloid, Acute miR-206 inhibitor reversed the repressive role of ZNF667-AS1 knockdown in cell proliferation, invasion and tumorigenesis, while AKAP13 silencing flattened the stimulative role of miR-206 inhibitor in AML malignant aggressiveness. +genetics_knock down_suppress 33380810 hsa-mir-370 Ovarian Neoplasms Knockdown of Circular RNA Hsa_circ_0000714 Can Regulate RAB17 by Sponging miR-370-3p to Reduce Paclitaxel Resistance of Ovarian Cancer Through CDK6/RB Pathway. +target gene 33380807 hsa-mir-1256 Osteosarcoma The lncRNA LINC00691Functions as a ceRNA for miRNA-1256 to Suppress Osteosarcoma by Regulating the Expression of ST5. +other 33380806 hsa-mir-9 Breast Neoplasms Interactions Between lncRNA TUG1 and miR-9-5p Modulate the Resistance of Breast Cancer Cells to Doxorubicin by Regulating eIF5A2. +lncRNA target 33380803 hsa-mir-31 Lung Neoplasms 3p inhibitor partially abrogated the inhibitory effects of fentanyl on NSCLC cell viability and invasion by targeting HDAC5. +lncRNA target 33380402 hsa-mir-139 Asthma CONCLUSIONS: YHPC granule can enhance the inhibitory effect of BMSCs homing on Th2 inflammatory response in asthmatic rats by up-regulating miR +lncRNA target 33380387 hsa-mir-4443 Breast Neoplasms Transfection with miR-4443 mimics or inhibitors did not obviously affect apoptosis rate of the breast cancer cells (P>0.05), but significantly enhanced or weakened the migration and invasion abilities of the cells, respectively (P < 0.01). +genetics_overexpression_promote 33380310 hsa-mir-34a Diabetic Cardiomyopathies CONCLUSION: OIP5-AS1 overexpression enhanced viability and attenuated oxidative stress of cardiomyocyte via regulating miR-34a/SIRT1 axis in DCM, providing a new therapeutic target for DCM. +other 33379285 hsa-mir-5586 Carcinoma, Squamous Cell We established a logistic regression model in HNSC and CESC which included six miRNAs: hsa-miR-5586 (Exp (B): 2.94, p = 0.001), hsa-miR-632 (Exp (B): 10.75, p = 0.002), hsa-miR-2355 (Exp (B): 0.48, p = 0.004), hsa-miR-642a (Exp (B): 2.22, p = 0.01), hsa-miR2 (Exp (B): 0.39, p = 0.013) and hsa-miR-6728 (Exp (B): 0.21, p = 0.016). +other 33379285 hsa-mir-642a Carcinoma, Squamous Cell We established a logistic regression model in HNSC and CESC which included six miRNAs: hsa-miR-5586 (Exp (B): 2.94, p = 0.001), hsa-miR-632 (Exp (B): 10.75, p = 0.002), hsa-miR-2355 (Exp (B): 0.48, p = 0.004), hsa-miR-642a (Exp (B): 2.22, p = 0.01), hsa-miR2 (Exp (B): 0.39, p = 0.013) and hsa-miR-6728 (Exp (B): 0.21, p = 0.016). +other 33379285 hsa-mir-6728 Carcinoma, Squamous Cell We established a logistic regression model in HNSC and CESC which included six miRNAs: hsa-miR-5586 (Exp (B): 2.94, p = 0.001), hsa-miR-632 (Exp (B): 10.75, p = 0.002), hsa-miR-2355 (Exp (B): 0.48, p = 0.004), hsa-miR-642a (Exp (B): 2.22, p = 0.01), hsa-miR2 (Exp (B): 0.39, p = 0.013) and hsa-miR-6728 (Exp (B): 0.21, p = 0.016). +other 33379285 hsa-mir-632 Carcinoma, Squamous Cell We established a logistic regression model in HNSC and CESC which included six miRNAs: hsa-miR-5586 (Exp (B): 2.94, p = 0.001), hsa-miR-632 (Exp (B): 10.75, p = 0.002), hsa-miR-2355 (Exp (B): 0.48, p = 0.004), hsa-miR-642a (Exp (B): 2.22, p = 0.01), hsa-miR2 (Exp (B): 0.39, p = 0.013) and hsa-miR-6728 (Exp (B): 0.21, p = 0.016). +other 33379285 hsa-mir-101-2 Carcinoma, Squamous Cell We established a logistic regression model in HNSC and CESC which included six miRNAs: hsa-miR-5586 (Exp (B): 2.94, p = 0.001), hsa-miR-632 (Exp (B): 10.75, p = 0.002), hsa-miR-2355 (Exp (B): 0.48, p = 0.004), hsa-miR-642a (Exp (B): 2.22, p = 0.01), hsa-miR2 (Exp (B): 0.39, p = 0.013) and hsa-miR-6728 (Exp (B): 0.21, p = 0.016). +other 33379105 hsa-mir-21 Lung Neoplasms The developed method achieved a linear detection range from 200 amol to 100 fmol for miRNA-21 with a limit of detection of 50 amol, and successfully applied to detect endogenous miRNA-21 levels from lung cancer cells. +lncRNA target 33379103 hsa-mir-21 Breast Neoplasms Herein, we fabricated carbon dots-chitosan nanocomposite hydrogels via reacting carbon dots synthesized from various aldehyde precursors with chitosan after that functionalized with ssDNA probe for detection of microRNA-21 in MCF-7 cancer cells. +lncRNA target 33378944 hsa-mir-16 Carcinoma, Hepatocellular The mechanism study showed that miR5p was affected by TTN-AS1 sponge, up-regulated cyclin E1 expression, and regulated PTEN/Akt signaling pathway, thereby significantly alleviating the inhibition of apoptosis of HCC cells induced by TTN-AS1 gene. +other 33378933 hsa-mir-940 Adenocarcinoma of Lung miRNA index (miR.index), constructed with nine miRNAs (hsa-let-7i, hsa-mir-1976, hsa-mir-199a-1, hsa-mir-31, hsa-mir-3940, hsa-mir-450a-2, hsa-mir-4677, hsa-mir-548v and hsa-mir-6803), was an independent prognostic indicator for the survival of patients with LUAD. +other 33378933 hsa-mir-1 Adenocarcinoma of Lung miRNA index (miR.index), constructed with nine miRNAs (hsa-let-7i, hsa-mir-1976, hsa-mir-199a-1, hsa-mir-31, hsa-mir-3940, hsa-mir-450a-2, hsa-mir-4677, hsa-mir-548v and hsa-mir-6803), was an independent prognostic indicator for the survival of patients with LUAD. +other 33378933 hsa-mir-548v Adenocarcinoma of Lung miRNA index (miR.index), constructed with nine miRNAs (hsa-let-7i, hsa-mir-1976, hsa-mir-199a-1, hsa-mir-31, hsa-mir-3940, hsa-mir-450a-2, hsa-mir-4677, hsa-mir-548v and hsa-mir-6803), was an independent prognostic indicator for the survival of patients with LUAD. +other 33378933 hsa-let-7i Adenocarcinoma of Lung miRNA index (miR.index), constructed with nine miRNAs (hsa-let-7i, hsa-mir-1976, hsa-mir-199a-1, hsa-mir-31, hsa-mir-3940, hsa-mir-450a-2, hsa-mir-4677, hsa-mir-548v and hsa-mir-6803), was an independent prognostic indicator for the survival of patients with LUAD. +other 33378933 hsa-mir-1976 Adenocarcinoma of Lung miRNA index (miR.index), constructed with nine miRNAs (hsa-let-7i, hsa-mir-1976, hsa-mir-199a-1, hsa-mir-31, hsa-mir-3940, hsa-mir-450a-2, hsa-mir-4677, hsa-mir-548v and hsa-mir-6803), was an independent prognostic indicator for the survival of patients with LUAD. +other 33378933 hsa-mir-450a-2 Adenocarcinoma of Lung miRNA index (miR.index), constructed with nine miRNAs (hsa-let-7i, hsa-mir-1976, hsa-mir-199a-1, hsa-mir-31, hsa-mir-3940, hsa-mir-450a-2, hsa-mir-4677, hsa-mir-548v and hsa-mir-6803), was an independent prognostic indicator for the survival of patients with LUAD. +other 33378933 hsa-mir-6803 Adenocarcinoma of Lung miRNA index (miR.index), constructed with nine miRNAs (hsa-let-7i, hsa-mir-1976, hsa-mir-199a-1, hsa-mir-31, hsa-mir-3940, hsa-mir-450a-2, hsa-mir-4677, hsa-mir-548v and hsa-mir-6803), was an independent prognostic indicator for the survival of patients with LUAD. +other 33378933 hsa-mir-4677 Adenocarcinoma of Lung miRNA index (miR.index), constructed with nine miRNAs (hsa-let-7i, hsa-mir-1976, hsa-mir-199a-1, hsa-mir-31, hsa-mir-3940, hsa-mir-450a-2, hsa-mir-4677, hsa-mir-548v and hsa-mir-6803), was an independent prognostic indicator for the survival of patients with LUAD. +other 33378933 hsa-mir-199a-1 Adenocarcinoma of Lung miRNA index (miR.index), constructed with nine miRNAs (hsa-let-7i, hsa-mir-1976, hsa-mir-199a-1, hsa-mir-31, hsa-mir-3940, hsa-mir-450a-2, hsa-mir-4677, hsa-mir-548v and hsa-mir-6803), was an independent prognostic indicator for the survival of patients with LUAD. +transcription factor target 33378838 hsa-mir-10b Huntington Disease In conclusion, hsa-miR-10b-5p and hsa-miR-196a-5p were significantly and differentially expressed in Huntington's disease, the long non-coding RNAs X-inactive specific transcript, taurine upregulated gene 1, and target genes such as homeobox or brain-derived neurotrophic factor may play critical roles in the pathogenesis of Huntington's disease. +transcription factor target 33378838 hsa-mir-196a Huntington Disease In conclusion, hsa-miR-10b-5p and hsa-miR-196a-5p were significantly and differentially expressed in Huntington's disease, the long non-coding RNAs X-inactive specific transcript, taurine upregulated gene 1, and target genes such as homeobox or brain-derived neurotrophic factor may play critical roles in the pathogenesis of Huntington's disease. +other 33378474 hsa-mir-34a Otitis Media OBJECTIVES: To explore the expression of miR-34a and its effect on expression of matrix metalloproteinases (MMPs) during orthodontic tooth movement (OTM). The results suggest that miR-34a is involved in expression of MMPs during OTM. +other 33378474 hsa-mir-34 Otitis Media OBJECTIVES: To explore the expression of miR-34a and its effect on expression of matrix metalloproteinases (MMPs) during orthodontic tooth movement (OTM). The results suggest that miR-34a is involved in expression of MMPs during OTM. +other 33378320 hsa-mir-187 Sepsis Network analysis and RT-qPCR revealed that septic hearts treated with MSCs resulted in upregulation of five miRNAs, including miR-187, and decrease in three top hit putative hub genes (Itpkc, Lrrc59, and Tbl1xr1). +transcription factor target 33378040 hsa-mir-506 Myocardial Reperfusion Injury CONCLUSIONS: MiR-506 is associated with myocardial injury in rats, which can alleviate myocardial injury through the PI3K/AKT signaling pathway. +lncRNA target 33378038 hsa-mir-873 Hypoxia Besides, inhibiting lncRNA XIST could upregulate miR +lncRNA target 33378038 hsa-mir-873 Myocardial Infarction 5p protected the heart against apoptosis after AMI, and lncRNA XIST inhibited apoptosis in H9c2 cells after hypoxia. +lncRNA target 33378037 hsa-mir-217 Atherosclerosis OBJECTIVE: To determine the effect of miR-217 on the apoptosis of atherosclerotic endothelial cells (AECs) through the Toll-like receptor (TLR) 4/PI3K/Akt/NF-kappaB pathway. MATERIALS AND METHODS: Oxidized low-density lipoprotein (ox-LDL) was used to construct an atherosclerotic endothelial cell model, and the expression of miR-217/TLR4/PI3K/Akt/NF-kappaB in the cells was regulated to explore their effects on the viability, apoptosis, inflammatory factors [tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-10 (IL-10)], and endothelial-to-mesenchymal transformation (EndMT) of the endothelial cells. +circulation_biomarker_diagnosis_up 33378036 hsa-mir-582 Hyperglycemia RESULTS: Results showed that compared with non-T2DM patients, UCA1 was markedly downregulated, while miR5p was upregulated in VSMCs and serum exosomes of T2DM patients. +transcription factor target 33378035 hsa-mir-190b Atherosclerosis This progression mechanism may target the miR-190b/ATG7 signal pathway, which indicates a suitable role in the pathogenesis of atherosclerosis. +circulation_biomarker_diagnosis_down 33378033 hsa-mir-24 Diabetes Mellitus 5p exerts an inhibitory effect on T2DM-induced inflammation in blood vessels by negatively regulating CPT1A level and reducing the release of inflammatory factors. +other 33378026 hsa-mir-146a Pancreatitis OBJECTIVE: This study aimed to explore the association of microRNA(miR)-146a and miR-146b expressions with risk, severity, in-hospital death of acute pancreatitis (AP). +circulation_biomarker_prognosis_ns 33378026 hsa-mir-146b Pancreatitis CONCLUSIONS: Circulating miR-146a and miR-146b exhibit potential as markers for AP management and prognosis. +circulation_biomarker_diagnosis_up 33378024 hsa-mir-21 Mucocutaneous Lymph Node Syndrome CONCLUSIONS: MiRNA-21 and NT-proBNP are upregulated in plasma of children with KD. +genetics_knock down_promote 33378023 hsa-mir-493 Neuroblastoma Moreover, TRIM2 was demonstrated to be directly targeted by miR-493, and the upregulation of TRIM2 could abolish the inhibitory effect of miR-493 overexpression on the progression of NB. +genetics_overexpression_promote 33378022 hsa-mir-587 Carcinoma, Non-Small-Cell Lung Overexpression of CYLD could partially abolish the regulatory effects of overexpressed miR-587 on promoting proliferative and migratory abilities in NSCLC cells. +lncRNA target 33378019 hsa-mir-133b Squamous Cell Carcinoma of Head and Neck Down-regulation of miR-133b reduced the proliferation, invasion and migration of OSCC cells via regulating SOX4. +genetics_overexpression_promote 33378016 hsa-mir-15a Carcinoma, Hepatocellular Overexpression of HMOX1 abolished the regulatory effects of miRNA-15a-3p on HCC cell phenotypes. +other 33378013 hsa-mir-3681 Carcinoma, Hepatocellular 3p, thereby participating in the progression of HCC. +lncRNA target 33378012 hsa-mir-122 Osteosarcoma 5) targeting tumor protein p53 (TP53) gene to mediate PI3K-Akt-mTOR signaling pathway on the proliferation and apoptosis of osteosarcoma (OS) cells. +lncRNA target 33377748 hsa-mir-216a Lymphoma, Large B-Cell, Diffuse The invasion of DLBCL was suppressed by miR-216a. +circulation_biomarker_diagnosis_ns 33377728 hsa-mir-184 Infertility, Male CONCLUSIONS: The miR-184 level in the seminal plasma exosome of infertility patients is significantly different from that of normal fertile males, which may serve as a potential auxiliary marker for the diagnosis of and participate in the development and progression of male infertility. +genetics_GWAS 33377704 hsa-mir-34c Infertility, Male We collected the clinical data and peripheral blood samples from the subjects, genotyped microRNA-34b/c rs4938723 by Sequenom MassARRAY, and analyzed the relationship between the genotypes of microRNA-34b/c rs4938723 and the risk of male infertility using the logistic regression model. CONCLUSIONS: No correlation was found between microRNA-34b/c SNP rs4938723 and male infertility, which, however, needs to be further verified by larger-sized samples. +genetics_GWAS 33377704 hsa-mir-34b Infertility, Male We collected the clinical data and peripheral blood samples from the subjects, genotyped microRNA-34b/c rs4938723 by Sequenom MassARRAY, and analyzed the relationship between the genotypes of microRNA-34b/c rs4938723 and the risk of male infertility using the logistic regression model. CONCLUSIONS: No correlation was found between microRNA-34b/c SNP rs4938723 and male infertility, which, however, needs to be further verified by larger-sized samples. +genetics_overexpression_promote 33377649 hsa-mir-516a Urinary Bladder Neoplasms RESULTS: A more invasive BC phenotype was significantly and positively correlated with miR-516a overexpression in BC patients. +circulation_biomarker_diagnosis_up 33376728 hsa-mir-146a Carotid Artery Diseases The aim of this study was to investigate the expression and significance of miRNA-146a in peripheral blood of patients with carotid atherosclerosis (CAS). +other 33376550 hsa-mir-21 Leukemia, Myeloid, Acute Our study revealed functional and mechanistic associations between miR-21 and BCL11B in Thp-1 cells, which could serve to guide clinical treatment of AML. +genetics_overexpression_promote 33376550 hsa-mir-21 Leukemia Further experiments demonstrated that overexpression of miR-21 in Thp-1 human monocytes derived from acute mononuclear leukemia peripheral blood promoted cell proliferation, while downregulation of miR +other 33376537 hsa-mir-370 Breast Neoplasms LINC00324, MIR22HG, miR-370-3p and miR-424-5p were identified as potential prognostic and therapeutic biomarkers for breast cancer. +other 33376537 hsa-mir-424 Breast Neoplasms LINC00324, MIR22HG, miR-370-3p and miR-424-5p were identified as potential prognostic and therapeutic biomarkers for breast cancer. +transcription factor target 33376536 hsa-mir-15a Glioblastoma The results further demonstrated that, through the inhibition of cell adhesion molecule 1 expression and the promotion of Akt phosphorylation, miR-15a-5p was able to promote GBM cell proliferation and invasion. +other 33376524 hsa-mir-1307 Stomach Neoplasms Upregulation of miR-1307-3p and its function in the clinical prognosis and progression of gastric cancer. +lncRNA target 33376521 hsa-mir-633 Melanoma Furthermore, miR-633 mimics over expression was shown to suppress both mRNA and protein expression of KAI1, while miR-633 inhibition resulted in decreased viability and migrationin melanoma cells in vitro. +lncRNA target 33376520 hsa-mir-206 Lung Neoplasms In summary, our results suggest that LINC00887 may serve an oncogenic role in lung carcinoma by targeting the miR-206/NRP1 axis, providing a potential therapeutic target for patients with lung carcinoma. +lncRNA target 33376513 hsa-mir-190a Intervertebral Disc Degeneration Collectively, these results suggest that PART1 accelerates the progression of IDD by directly targeting miR-190a-3p, which provides a novel target for IDD diagnosis and treatment. +genetics_overexpression_promote 33376485 hsa-mir-326 Colorectal Neoplasms Finally, suppression of miR-326 or overexpression of LASP1 could sufficiently rescue the aberrant cell growth and apoptosis in CRC cell lines. Taken together, our results indicated that downregulation of hsa_circRNA_000166 inhibited the cell growth and facilitated apoptosis during CRC development by sponging the miR-326/LASP1 pathway. +other 33376405 hsa-mir-519d Colorectal Neoplasms CONCLUSION: BLACAT1 mediated the progression of CRC and OXA-resistance by miR-519d-3p/CREB1 axis. +other 33376399 hsa-mir-6828 Colorectal Neoplasms Finally, BGN effects on CRC cell proliferation, cycle, apoptosis, invasion, and migration were studied using molecular biological methods, including luciferase reporter-based protein analysis, qRT-PCR, and Western blot results, which revealed that miR5p may regulate BGN expression. +target gene 33376397 hsa-mir-138 Stomach Neoplasms H19 Rises in Gastric Cancer and Exerts a Tumor-Promoting Function via miR-138/E2F2 Axis. +other 33376373 hsa-mir-182 Diabetes Mellitus, Type 2 5p. +other 33376373 hsa-mir-182 Prediabetic State 5p. +lncRNA target 33376349 hsa-mir-612 Stomach Neoplasms miR-612 suppressed the expression of CDC5L in GC tissues and cells. +target gene 33376348 hsa-mir-519d Breast Neoplasms MiR-519d and miR-328-3p Combinatorially Suppress Breast Cancer Progression. +target gene 33376348 hsa-mir-28 Breast Neoplasms MiR-519d and miR-328-3p Combinatorially Suppress Breast Cancer Progression. +circulation_biomarker_diagnosis_up 33375812 hsa-mir-26a Atrial Fibrillation MicroRNA-26a was predicted to target ITPR1 (confirmed by luciferase assay) and was downregulated in AF atrial cardiomyocytes; microRNA-26a silencing reproduced AF-induced IP(3)R1 upregulation and nuclear diastolic Ca(2+)-loading. CONCLUSIONS: AF increases atrial-cardiomyocyte nucleoplasmic [Ca(2+)] by IP(3)R1-upregulation involving miR-26a, leading to enhanced IP(3)R1-CaMKII-HDAC4 signaling and L-type calcium current downregulation. +other 33375517 hsa-mir-4496 Glioblastoma These findings suggest that CKAP2L is a vital regulator of miR-4496 activity and that CKAP2L is a potentially useful prognostic marker in glioma. +genetics_GWAS 33375320 hsa-mir-146a Ischemic Stroke CONCLUSIONS: Our results indicate that higher cIMT levels were significantly associated with IS and LAA subtype but not SVO subtype, and the relations were modified by rs2910164 polymorphism in miR-146a. +other 33375048 hsa-mir-26 Gaucher Disease CONCLUSIONS: We revealed few miRNAs, like miR5p, which are highly altered and fit the GD pathophysiological model, might be considered as novel biomarkers of disease progression but need further evaluation. +genetics_overexpression_suppress 33374832 hsa-mir-34a Breast Neoplasms Finally, the overexpression of microRNA-34a (miR-34a), which is a well-described EMT-inhibiting miRNA and targets AXL, inhibited VM formation, migration, and invasion in MDA-MB 231 cells. These results identify a miR-34a-AXL axis that is critical for the regulation of VM formation and may serve as a therapeutic target to inhibit tumor neovascularization. +other 33374439 hsa-mir-497 Endometrial Neoplasms 5p expression, in addition to the traditional clinical and histopathologic parameters, slightly improves the prediction accuracy of EC diagnosis. +lncRNA target 33374314 hsa-mir-614 Breast Neoplasms Together, our results reveal how increased miR614 expression and the suppression of TAPT1 and Miro1 modulate the EMT state and migratory properties of breast cancer cells. +other 33374290 hsa-mir-340 Myocardial Infarction We also found lower levels of miR-340 and miR-424 and higher levels of miR-29b in the patients with IS and MI compared with the HCs. Lastly, we found higher miR-340 levels in IS than in MI. +other 33374290 hsa-mir-340 Ischemic Stroke We also found lower levels of miR-340 and miR-424 and higher levels of miR-29b in the patients with IS and MI compared with the HCs. Lastly, we found higher miR-340 levels in IS than in MI. +lncRNA target 33373887 hsa-mir-128 Neuralgia SUMMARY: NEAT1 affects AQP4 signaling pathway to alleviate the spinal cord injury-induced NP via promoting miR3p expression. +lncRNA target 33373887 hsa-mir-128 Spinal Cord Injuries SUMMARY: NEAT1 affects AQP4 signaling pathway to alleviate the spinal cord injury-induced NP via promoting miR3p expression. +genetics_overexpression_promote 33372873 hsa-mir-375 Esophageal Squamous Cell Carcinoma Overexpression of miR-375 inhibited proliferation, invasion and migration of ESCC cells, and greatly reduced the promoting effect of XPR1 overexpression on cell proliferation, migration and invasion. +other 33372851 hsa-mir-1247 Urinary Bladder Neoplasms 3p in the diagnosis of bladder cancer. +genetics_knock down_promote 33372601 hsa-mir-641 Adenocarcinoma of Lung Rescue experiments showed that miR-641 inhibition and SETD7 overexpression rescued the repressing impacts on LUAD cell proliferation, migration and invasion caused by LINC01194 knockdown. +circulation_biomarker_diagnosis_ns 33372399 hsa-mir-1247 Carcinoma, Non-Small-Cell Lung KEY POINTS: Plasma miR +circulation_biomarker_diagnosis_ns 33372399 hsa-mir-105 Carcinoma, Non-Small-Cell Lung KEY POINTS: Plasma miR +lncRNA target 33372396 hsa-mir-1305 Hepatitis B Collectively, our data suggest that circ-ARL3 is a critical regulator in HBV-related HCC, targeting the axis of circ-ARL3/miR-1305 may be a promising treatment for HBV(+) HCC patients. +lncRNA target 33372396 hsa-mir-1305 Carcinoma, Hepatocellular Collectively, our data suggest that circ-ARL3 is a critical regulator in HBV-related HCC, targeting the axis of circ-ARL3/miR-1305 may be a promising treatment for HBV(+) HCC patients. +genetics_overexpression_suppress 33372376 hsa-mir-18b Liver Neoplasms SNHG15 and LMO4 were overexpressed while miR-18b-5p was downregulated in liver cancer tissues and cells. +circRNA target 33372369 hsa-mir-375 Polycystic Ovary Syndrome In conclusion, circASPH promotes KGN cells proliferation through miR-375/MAP2K6 axis in PCOS, and they are thought-provoking biomarkers for PCOS diagnosis and therapy. +genetics_knock down_promote 33372356 hsa-mir-378 Ovarian Neoplasms Overexpression of circATRNL1 or knockdown of miR-378 suppressed angiogenesis and ovarian cancer cell proliferation, invasion, and migration via decreasing proliferation- and migration-related proteins via miR-378 or Smad4, respectively. +other 33372325 hsa-mir-27a Teratozoospermia The study aimed to evaluate the alterations of testicular and/or spermatozoal potassium voltage-gated channel subfamily J member 11 (KCNJ11), Cystic fibrosis transmembrane conductance regulator (CFTR), miR-let-7a and miR-27a expressions in carbamazepine-related male infertility. +other 33372325 hsa-let-7a Teratozoospermia The study aimed to evaluate the alterations of testicular and/or spermatozoal potassium voltage-gated channel subfamily J member 11 (KCNJ11), Cystic fibrosis transmembrane conductance regulator (CFTR), miR-let-7a and miR-27a expressions in carbamazepine-related male infertility. +lncRNA target 33371810 hsa-mir-15a Pancreatitis In conclusion, baicalin exhibits therapeutic activity towards AP by pumping up miR-15a level and inhibiting CDC42/MAP3K1, which affects AP as a brake by targeting MAP2K4 and inhibiting the JNK signaling pathway. +other 33371806 hsa-mir-182 Breast Neoplasms 5p-CDKN2B-AS1 interactions were speculated to involve in the development of early BC. +other 33371806 hsa-mir-145 Breast Neoplasms 5p-CDKN2B-AS1 interactions were speculated to involve in the development of early BC. +other 33371806 hsa-mir-21 Breast Neoplasms 5p-CDKN2B-AS1 interactions were speculated to involve in the development of early BC. +other 33371795 hsa-mir-582 Squamous Cell Carcinoma of Head and Neck 5p could predict the occurrence of LSCC. +other 33371795 hsa-mir-338 Squamous Cell Carcinoma of Head and Neck 5p could predict the occurrence of LSCC. +other 33371795 hsa-mir-139 Squamous Cell Carcinoma of Head and Neck 5p could predict the occurrence of LSCC. +lncRNA target 33371778 hsa-mir-299 Stomach Neoplasms In a word, lncRNA HCP5 silencing inhibits GC cell proliferation, invasion, and migration while promoting its apoptosis via regulation of miR3p/SMAD5 axis. +other 33371368 hsa-mir-34a Breast Neoplasms Adipocyte-Derived Leptin Promotes PAI-1 -Mediated Breast Cancer Metastasis in a STAT3/miR-34a Dependent Manner. +circulation_biomarker_diagnosis_up 33371070 hsa-mir-25 Carcinoma, Non-Small-Cell Lung Many studies have shown that there is a significant increment of miR-25 in circulating blood of patients with NSCLC. +genetics_knock down_promote 33370717 hsa-mir-1 Chordoma Tumorigenesis of spinal chordoma in vivo was also inhibited by knockdown of LINC00525 via the promotion of miR +genetics_knock down_promote 33370717 hsa-mir-125a Chordoma Tumorigenesis of spinal chordoma in vivo was also inhibited by knockdown of LINC00525 via the promotion of miR +circRNA target 33370579 hsa-mir-106b Epilepsy, Temporal Lobe Our study suggested that the enforced expression of circ_DROSHA alleviated the cell damage of the TLE cell model at least in part through the regulation of the miR-106b-5p/MEF2C axis. +lncRNA target 33370525 hsa-mir-34c Lung Neoplasms CONCLUSION: At the molecular level, IL-6 can be used as a direct target of miR-34c in the treatment of lung cancer cells and miR-34c can be used as an effective biomarker and therapeutic target for lung cancer. +lncRNA target 33370523 hsa-mir-23b Colorectal Neoplasms CONCLUSION: We demonstrated the expression of TUSC7 suppressed colorectal cancer progression through the TUSC7/miR-23b/PDE7A axis, suggesting that TUSC is a potential target for therapeutic intervention in colorectal cancer. +genetics_knock down_promote 33369809 hsa-mir-423 Osteosarcoma Knockdown of circPVT1 or overexpression of miR +transcription factor target 33369441 hsa-mir-4731 Glioma In conclusions, we identified that miR-4731 plays a tumor suppressor role in GBM cell proliferation and migration by targeting EGFR expression, and miR-4731 may act as a novel biomarker for early diagnosis or therapeutic target of GBM. +other 33369227 hsa-mir-574 Heart Failure Together, we discovered that miR-574 regulates FAM210A expression and modulates mitochondrial-encoded protein expression, which may influence cardiac remodeling in heart failure. +lncRNA target 33369107 hsa-mir-125b Uterine Cervical Neoplasms miR-125b and its target Gab2, which are strongly associated with PAR(2) -induced cell migration, are well-characterized as predictors of the prognostic value of CESC. +lncRNA target 33368965 hsa-mir-499b Pneumonia Collectively, these observations illuminated that UCA1 inhibition protected WI-38 cells against LPS-managed inflammatory injury and apoptosis process via miR-499b-5p/TLR4 crosstalk, which ultimately influencing the development of pneumonia. +circulation_biomarker_prognosis_ns 33368640 hsa-mir-29a Thyroid Cancer, Papillary CONCLUSION: These results demonstrated that serum exosomal miR-29a might serve as a potential biomarker for PTC diagnosis and prognosis. +genetics_overexpression_promote 33368623 hsa-mir-17 Carcinoma, Non-Small-Cell Lung 5p overexpression inhibited cell proliferation and migration invasion in NSCLC cells. +genetics_overexpression_promote 33368410 hsa-mir-150 Acquired Immunodeficiency Syndrome In addition, HIV infection led to an enhanced influx of glucose inside the infected cells, which further increased on overexpression of miR-150. +lncRNA target 33368266 hsa-mir-939 Triple Negative Breast Neoplasms 5p was characterized as a tumor suppressor miRNA while HEIH was categorized as a novel oncogenic lncRNA in TNBC. +other 33368224 hsa-mir-146 Colorectal Neoplasms Here, we collected the tissue samples from 48 patients with colorectal cancer (47.91% females and mean age 55 /- 8.20) and 48 healthy people at the First Affiliated Hospital of Nanjing Medical University to detect the miR5p expression. +genetics_knock down_promote 33367930 hsa-mir-150 Breast Neoplasms The functional rescue assay results demonstrated that MAFGAS1 knockdown suppressed the proliferation and migration of breast cancer cells by regulating miR1505p, which in turn targeted MYB. +other 33367814 hsa-mir-20a Diabetes Mellitus, Type 2 Importantly, miR-320a was also significantly downregulated in human islets of subjects with type 2 diabetes and this was accompanied by increased glucagon expression. Thus, our data suggest that glucose-induced downregulation of miR-320a may contribute to the paradoxical increase in glucagon observed in type 2 diabetes and reveal for the first time that glucagon expression is under the control by a microRNA providing novel insight into the abnormal regulation of glucagon in diabetes. +other 33367814 hsa-mir-20a Diabetes Mellitus Importantly, miR-320a was also significantly downregulated in human islets of subjects with type 2 diabetes and this was accompanied by increased glucagon expression. Thus, our data suggest that glucose-induced downregulation of miR-320a may contribute to the paradoxical increase in glucagon observed in type 2 diabetes and reveal for the first time that glucagon expression is under the control by a microRNA providing novel insight into the abnormal regulation of glucagon in diabetes. +other 33367795 hsa-mir-210 Drug-Induced Kidney Injury Urinary miR3p increased up to 40-fold upon treatment with TAL toxicants and was also enriched in laser capture microdissection samples containing TAL and/or CD versus proximal tubule. +epigenetics 33365310 hsa-mir-199a Thyroid Cancer, Papillary The Suppression of miR-199a-3p by Promoter Methylation Contributes to Papillary Thyroid Carcinoma Aggressiveness by Targeting RAP2a and DNMT3a. +target gene 33365086 hsa-mir-34a Pancreatic Neoplasms Circular dumbbell miR-34a-3p and -5p suppresses pancreatic tumor cell-induced angiogenesis and activates macrophages. +circulation_biomarker_diagnosis_up 33365074 hsa-mir-141 Osteoarthritis, Knee NLR and miR-141 in peripheral blood and their diagnostic values for osteoarthritis were compared between the two groups. To sum up, NLR and miR-141 were significantly increased in the peripheral blood of patients with osteoarthritis. +circulation_biomarker_diagnosis_up 33365074 hsa-mir-141 Osteoarthritis NLR and miR-141 in peripheral blood and their diagnostic values for osteoarthritis were compared between the two groups. To sum up, NLR and miR-141 were significantly increased in the peripheral blood of patients with osteoarthritis. +genetics_knock down_promote 33365068 hsa-mir-155 Osteoarthritis, Knee 5p may serve as a potential therapeutic target for KOA. +circulation_biomarker_diagnosis_ns 33365067 hsa-mir-126 Myocardial Infarction 5p expression was significantly decreased in the serum samples of patients with AMI, whereas IL-17A, the target of miR +circulation_biomarker_diagnosis_down 33365060 hsa-mir-149 Pneumonia LncRNA MEG3 was highly expressed, whereas miR3p expression was downregulated in smokers with COPD peripheral blood samples, compared with non-smokers and smokers without COPD samples. +target gene 33364844 hsa-mir-143 Gallbladder Neoplasms Long Non-Coding RNA OIP5-AS1 Contributes to Gallbladder Cancer Cell Invasion and Migration by miR-143-3p Suppression. +exosome 33364842 hsa-mir-21 Melanoma Melanoma-Derived Exosomes Endow Fibroblasts with an Invasive Potential via miR-21 Target Signaling Pathway. +genetics_knock down_promote 33364841 hsa-mir-377 Carcinoma, Hepatocellular CircPVT1 could bind to miR-377 and inhibition of miR-377 restored circPVT1 knockdown-mediated effect on HCC cells. +target gene 33364835 hsa-mir-361 Stomach Neoplasms Long Noncoding RNA SNHG22 Induces Cell Migration, Invasion, and Angiogenesis of Gastric Cancer Cells via microRNA-361-3p/HMGA1/Wnt/β-Catenin Axis. +genetics_knock down_suppress 33364834 hsa-mir-198 Colorectal Neoplasms CONCLUSION: Knockdown of circ-PRKDC inhibited CRC progression via modulating miR-198/DDR1 pathway. +genetics_overexpression_promote 33364827 hsa-mir-940 Carcinoma, Non-Small-Cell Lung NOVA2 overexpression also neutralized the miR +exosome 33364805 hsa-mir-19b Wound Healing Human Adipose-Derived Mesenchymal Stem Cells-Derived Exosomal microRNA-19b Promotes the Healing of Skin Wounds Through Modulation of the CCL1/TGF-β Signaling Axis. +target gene 33364499 hsa-mir-1911 Lung Neoplasms MicroRNA-1911-3p targets mEAK-7 to suppress mTOR signaling in human lung cancer cells. +genetics_overexpression_promote 33364257 hsa-mir-487b Carcinoma, Hepatocellular Overexpression of miR-487b was associated with Tumor Node Metastasis stage stage and Barcelona Clinic Liver Cancer stage in HCC patients. +other 33364236 hsa-mir-497 Lymphoma, T-Cell XIST sponges miR-497 to promote Bcl-w expression, and finally modulating ENKL cell proliferation and migration. +target gene 33363617 hsa-mir-214 Ovarian Neoplasms Long non-coding RNA SNHG9 inhibits ovarian cancer progression by sponging microRNA-214-5p. +genetics_knock down_promote 33363587 hsa-mir-15b Esophageal Neoplasms The results of the gain/loss-of-function in vitro experiments indicated that miR-15b inhibited EC cell viability, migration and invasion, facilitated EC cell apoptosis and attenuated the PI3K/AKT signalling pathway in EC109 and TE10 cells. +circulation_biomarker_diagnosis_up 33363573 hsa-mir-125a Adenocarcinoma of Lung In term of mechanism, ST8SIA6-AS1 was transcriptionally repressed by tumor suppressor p53, and ST8SIA6-AS1 was mainly located in the cytoplasm and could abundantly sponge miR-125a-3p to increase nicotinamide N-methyltransferase (NNMT) expression, thereby facilitating LUAD malignant progression. Collectively, our data demonstrate that ST8SIA6-AS1 is a carcinogenic lncRNA in LUAD, and targeting the axis of ST8SIA6-AS1/miR-125a-3p/NNMT may be a promising treatment for LUAD patients. +lncRNA target 33363214 hsa-mir-495 Urinary Bladder Neoplasms In order to prove the utility of this platform, we chose beta -catenin, NF-kappaB, miR-940, and miR-495 as the functional targets and used the bladder cancer cell lines 5637 and T24 as the test models. +lncRNA target 33363214 hsa-mir-940 Urinary Bladder Neoplasms In order to prove the utility of this platform, we chose beta -catenin, NF-kappaB, miR-940, and miR-495 as the functional targets and used the bladder cancer cell lines 5637 and T24 as the test models. +exosome 33363169 hsa-mir-29a Osteoporosis Taken together, these findings suggest that BMSC-derived exosomal miR-29a regulates angiogenesis and osteogenesis, and miR-29a-loaded BMSCs-Exos may serve as a potential therapeutic target for osteoporosis. +lncRNA target 33363164 hsa-mir-876 Thyroid Cancer, Papillary 3p-CTNNB1/CCND1 axis linked to carcinogenesis and progression of PTC, which may provide promising therapeutic targets in treating PTC in the future. +lncRNA target 33363153 hsa-mir-216a Sarcoma, Ewing We found that PD-L1 levels in aggressive EC cells are regulated by miR-216a, which directly targets PD-L1. CONCLUSION: These results reveal an unappreciated tumor cell-intrinsic role for PD-L1 as a tumor suppressor in aggressive EC cells, and identify MEG3 and miR-216a as upstream regulators of PD-L1. +target gene 33363140 hsa-mir-454 Glioma EZH2-Inhibited MicroRNA-454-3p Promotes M2 Macrophage Polarization in Glioma. +lncRNA target 33363013 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck We demonstrate that CircRNA_ACAP2 functions as a tumor suppressor gene in HNSCC and that its function is regulated via the miR +circulation_biomarker_diagnosis_up 33362968 hsa-mir-145 Breast Neoplasms CONCLUSIONS: Two plasma miRNAs-miR +circulation_biomarker_diagnosis_up 33362968 hsa-mir-191 Breast Neoplasms CONCLUSIONS: Two plasma miRNAs-miR +circulation_biomarker_diagnosis_up 33362958 hsa-mir-135a Nephrotic Syndrome Moreover, a significant decrease was observed in the expression level of miR-135a-5p in the plasma of patients with NS (P = 0.020), MGN (P = 0.040), and FSGS (P = 0.046) compared to the control group. +circulation_biomarker_diagnosis_up 33362958 hsa-mir-135 Nephrotic Syndrome Moreover, a significant decrease was observed in the expression level of miR-135a-5p in the plasma of patients with NS (P = 0.020), MGN (P = 0.040), and FSGS (P = 0.046) compared to the control group. +circulation_biomarker_prognosis_ns 33362864 hsa-mir-26a Rhabdomyosarcoma Taken together, these findings demonstrate the potential of circulating miRNA as diagnostic and prognostic biomarker in children affected by this malignancy and enforced the key role of miR-26a in pediatric rhabdomyosarcoma. +circulation_biomarker_diagnosis_up 33362864 hsa-mir-206 Rhabdomyosarcoma Interestingly, plasma levels of muscle-specific miR-206 were found to be significantly increased in RMS patients compared to HD, whereas levels of three potential tumor-suppressor miRNAs, miR-26a and miR-30b/30c, were found lower. +transcription factor target 33362712 hsa-mir-134 Nonfunctioning Pituitary Neuroendocrine Tumor CONCLUSION: The regulation of the SDF-1alpha/miR-134/VEGFA axis represents a novel mechanism in the pathogenesis of NF-PitNETs and may serve as a potential therapeutic target for the treatment of NF-PitNETs. +circulation_biomarker_diagnosis_ns 33361718 hsa-mir-182 Liver Cirrhosis The aim of this study was to identify the expression level of selected miRNAs (miR-182, miR-301a, and miR-373) in exosomes of the serum and ascitic fluid in patients with non-alcoholic steatohepatitis (NASH)-related liver cirrhosis with or without hepatocellular carcinoma (HCC). +circulation_biomarker_diagnosis_ns 33361718 hsa-mir-182 Carcinoma, Hepatocellular The aim of this study was to identify the expression level of selected miRNAs (miR-182, miR-301a, and miR-373) in exosomes of the serum and ascitic fluid in patients with non-alcoholic steatohepatitis (NASH)-related liver cirrhosis with or without hepatocellular carcinoma (HCC). +circulation_biomarker_diagnosis_up 33361718 hsa-mir-373 Carcinoma, Hepatocellular CONCLUSIONS: This preliminary data showed significant increase in the expression levels of exosomal miR-182, miR-301a and miR- 373 in both serum and ascetic fluid suggesting the possible roles of these miRNAs as circulating biomarkers for NASH-induced liver cirrhosis with hepatocellular carcinoma. +circulation_biomarker_diagnosis_up 33361718 hsa-mir-373 Liver Cirrhosis CONCLUSIONS: This preliminary data showed significant increase in the expression levels of exosomal miR-182, miR-301a and miR- 373 in both serum and ascetic fluid suggesting the possible roles of these miRNAs as circulating biomarkers for NASH-induced liver cirrhosis with hepatocellular carcinoma. +lncRNA target 33361582 hsa-mir-3666 Ovarian Neoplasms We uncovered that miR-3666 inhibited the tumorigenesis and even development of OC via suppressing STAT3/AK4 axis, offering a novel biomarker and therapeutic target for OC. +transcription factor target 33361033 hsa-mir-613 Alzheimer Disease Effects of velvet antler polypeptides on Alzheimer's disease cell model via miR-613 HDAC6 pathway. +genetics_overexpression_promote 33361019 hsa-mir-483 Osteoarthritis Overexpression of miR-483 could reverse the promotion effect of Toddalia asiatica extract on osteoarthritis chondrocytes proliferation, clone formation and IL-10 level, as well as reserve the inhibition effect of Toddalia asiatica extract on osteoarthritis chondrocyte apoptosis and levels of P21, caspase-3, TNF-alpha, IL-6. +lncRNA target 33360969 hsa-mir-130a Neuralgia CONCLUSION: The inhibition of miR-130a-3p expression up-regulates the IGF-1/IGF-1R signaling pathway, thus reducing neuropathic pain caused by spinal cord injury. +lncRNA target 33360969 hsa-mir-130a Spinal Cord Injuries CONCLUSION: The inhibition of miR-130a-3p expression up-regulates the IGF-1/IGF-1R signaling pathway, thus reducing neuropathic pain caused by spinal cord injury. +genetics_overexpression_suppress 33360300 hsa-mir-506 Ovarian Neoplasms, Serous 3p overexpression as a potential therapeutic for ovarian cancer. +lncRNA target 33360253 hsa-mir-181a Brain Ischemia CONCLUSION: miR-181a-5p suppression activated Wnt/beta-catenin pathway and sequentially attenuated cerebral ischemic injury by targeting En2. +other 33359828 hsa-mir-383 neonatal-onset type II citrullinemia In the liver, NIC offspring of both sexes showed lower Dio1 mRNA expression and higher miR-224 expression, while only NIC females had higher miR-383 and miR-21 expressions. +other 33359828 hsa-mir-224 neonatal-onset type II citrullinemia In the liver, NIC offspring of both sexes showed lower Dio1 mRNA expression and higher miR-224 expression, while only NIC females had higher miR-383 and miR-21 expressions. +other 33359828 hsa-mir-382 neonatal-onset type II citrullinemia In the BAT, NIC females showed higher Dio2 mRNA expression, while miR-382* expression was not altered in both sexes. +other 33359828 hsa-mir-21 neonatal-onset type II citrullinemia In the liver, NIC offspring of both sexes showed lower Dio1 mRNA expression and higher miR-224 expression, while only NIC females had higher miR-383 and miR-21 expressions. +other 33359828 hsa-mir-122 neonatal-onset type II citrullinemia NIC offspring of both sexes showed higher mRNA expression of SCD1 in the liver; NIC males had decreased CPT1 expression, whereas NIC females had increased FASN, miR-370 and miR-122 expressions. +lncRNA target 33359669 hsa-mir-383 Lung Neoplasms E2F7 was a target gene of miR-383 and its downregulation was responsible for the anti-cancerous role of miR-383 in lung cancer. CONCLUSION: Circ-CCS was shown to facilitate lung cancer progression via the miR-383/E2F7 axis, exhibiting the pivotal value of circ-CCS in diagnosis and treatment of lung cancer. +lncRNA target 33359565 hsa-mir-124 Carcinoma, Non-Small-Cell Lung 3p) to combinatorially regulate the expression of multiple targets (e.g., RAS, VAMP3 and CDK6) in human NSCLC cells, exhibiting greater efficacy than respective BERA miRNAs in the inhibition of cell viability and colony formation. +lncRNA target 33359565 hsa-let-7c Carcinoma, Non-Small-Cell Lung 3p) to combinatorially regulate the expression of multiple targets (e.g., RAS, VAMP3 and CDK6) in human NSCLC cells, exhibiting greater efficacy than respective BERA miRNAs in the inhibition of cell viability and colony formation. +other 33359498 hsa-mir-34a Chronic Kidney Disease Mechanistically, diabetes and HIV-1 synergistically increased the glomerular expression of microRNA-34a (miR-34a), thereby reducing the expression of Sirtuin-1 (SIRT1) deacetylase. +lncRNA target 33359304 hsa-mir-34a Pituitary Neoplasms In conclusion, CircNFIX affects cell invasion, migration, and proliferation in pituitary adenomas by sponging miR-34a-5p through CCNB1. +lncRNA target 33359248 hsa-mir-1 Inflammation SIGNIFICANCE: Our study demonstrated that down-regulating miR5p by Astaxanthin could be a potential therapeutic approach to suppress neuroinflammation via regulating microglia M1 activation. +transcription factor target 33359245 hsa-mir-383 Breast Neoplasms 5p could inhibit the migration of breast cancer cells via down-regulating metastasis-related genes. +other 33359189 hsa-mir-382 Spinal Cord Injuries 5p/Nrg1 axis improves the inflammation response of the microglia, which might improve SCI repair. +lncRNA target 33359177 hsa-mir-599 Urinary Bladder Neoplasms MiR-599 may inhibit the proliferation, invasion and promote apoptosis of bladder urothelial carcinoma J82 cells by targetingly regulating YAP1. +other 33359069 hsa-mir-199a Diabetic Nephropathies Collectively, these results indicate that urinary miR-199a-3p might be utilized as a marker for nephropathy treatment. +genetics_knock down_promote 33358903 hsa-mir-485 Osteosarcoma Knockdown MALAT1 or overexpression of miR +lncRNA target 33358902 hsa-mir-221 Carcinoma, Hepatocellular SIGNIFICANCE: Our study demonstrates that RNF185-AS1 is a new oncogenic lncRNA in HCC and suggests that the RNF185-AS1/miR5p/integrin beta5 axis might be a potential therapeutic target for HCC. +transcription factor target 33358886 hsa-mir-532 Endometriosis It is suggested that the dysregulation of miR +transcription factor target 33358886 hsa-mir-532 Infertility It is suggested that the dysregulation of miR +transcription factor target 33357782 hsa-mir-23b Osteoporosis, Postmenopausal In summary, inhibition of miR-23b-3p alleviates PMOP by targeting MRC2 to inhibit the Wnt/beta-catenin signaling, which may provide a novel molecular insight for osteoporosis therapy. +genetics_overexpression_promote 33357126 hsa-mir-155 Precursor Cell Lymphoblastic Leukemia-Lymphoma Overexpressed miR-155 promoted ALL cell proliferation and inhibited apoptosis. +lncRNA target 33356998 hsa-mir-424 Colorectal Neoplasms CONCLUSION: FENDRR is poorly expressed in CRC tissue and cells, and low FENDRR is responsible for the inhibition of cell proliferation, migration and invasion of CRC by means of targeting miR +circRNA target 33356989 hsa-mir-361 Carcinoma, Endometrioid 3p/SH2B1 in EC cells and regulated the progression of EC through the modulation of miR +lncRNA target 33356818 hsa-mir-222 Prostatic Neoplasms 3p might be a potential biomarker and therapeutic target of MPCa. +lncRNA target 33356812 hsa-mir-152 Colonic Neoplasms miR-145, miR-148a, and miR-152 directly suppress colonocyte ADAM17 and are down-regulated in colon cancer. +lncRNA target 33356812 hsa-mir-145 Colonic Neoplasms miR-145, miR-148a, and miR-152 directly suppress colonocyte ADAM17 and are down-regulated in colon cancer. +lncRNA target 33356812 hsa-mir-145 Colitis miR-145, miR-148a, and miR-152 directly suppress colonocyte ADAM17 and are down-regulated in colon cancer. +lncRNA target 33356812 hsa-mir-152 Colitis miR-145, miR-148a, and miR-152 directly suppress colonocyte ADAM17 and are down-regulated in colon cancer. +lncRNA target 33356812 hsa-mir-148a Colitis miR-145, miR-148a, and miR-152 directly suppress colonocyte ADAM17 and are down-regulated in colon cancer. +lncRNA target 33356812 hsa-mir-148a Colonic Neoplasms miR-145, miR-148a, and miR-152 directly suppress colonocyte ADAM17 and are down-regulated in colon cancer. +lncRNA target 33356743 hsa-mir-183 Laryngeal Neoplasms Overall, all results elucidated that miR-183, as an oncogenic molecule in LCa, may be used to predict the prognosis of LCa patients by targeting TMSB4Y. +circulation_biomarker_diagnosis_ns 33356031 hsa-mir-1910 psoriasis 1 ROC analysis showed that plasma miR +other 33355860 hsa-mir-125b Endometrial Neoplasms Aim of the study was to determine the relationship between the expression of miR-34a, miR-125b, miR-142 and miR-101 in endometrioid carcinomas of the endometrium (ECE) and the features of the disease course. CONCLUSIONS: The study revealed a significant heterogeneity of expression of miR-34a, miR-125b, miR-142 and miR-101 in ECE, which is associated with changes in morphofunctional characteristics of endometrial carcinoma. +other 33355860 hsa-mir-101 Endometrial Neoplasms Aim of the study was to determine the relationship between the expression of miR-34a, miR-125b, miR-142 and miR-101 in endometrioid carcinomas of the endometrium (ECE) and the features of the disease course. CONCLUSIONS: The study revealed a significant heterogeneity of expression of miR-34a, miR-125b, miR-142 and miR-101 in ECE, which is associated with changes in morphofunctional characteristics of endometrial carcinoma. +other 33355860 hsa-mir-34a Endometrial Neoplasms Aim of the study was to determine the relationship between the expression of miR-34a, miR-125b, miR-142 and miR-101 in endometrioid carcinomas of the endometrium (ECE) and the features of the disease course. CONCLUSIONS: The study revealed a significant heterogeneity of expression of miR-34a, miR-125b, miR-142 and miR-101 in ECE, which is associated with changes in morphofunctional characteristics of endometrial carcinoma. +other 33355860 hsa-mir-142 Endometrial Neoplasms Aim of the study was to determine the relationship between the expression of miR-34a, miR-125b, miR-142 and miR-101 in endometrioid carcinomas of the endometrium (ECE) and the features of the disease course. CONCLUSIONS: The study revealed a significant heterogeneity of expression of miR-34a, miR-125b, miR-142 and miR-101 in ECE, which is associated with changes in morphofunctional characteristics of endometrial carcinoma. +other 33355649 hsa-mir-126 Cognition Disorders RESULTS Older patients reaching ESRD showed an unfavorable angiogenic profile, as indicated by aberrant levels of Ang-2 and five angiogenic miRNAs (miR-27a, miR-126, miR-132, miR-223, miR-326), compared to healthy persons and patients with diabetic nephropathy. +other 33355649 hsa-mir-326 Cognition Disorders RESULTS Older patients reaching ESRD showed an unfavorable angiogenic profile, as indicated by aberrant levels of Ang-2 and five angiogenic miRNAs (miR-27a, miR-126, miR-132, miR-223, miR-326), compared to healthy persons and patients with diabetic nephropathy. +other 33355649 hsa-mir-223 Cognition Disorders RESULTS Older patients reaching ESRD showed an unfavorable angiogenic profile, as indicated by aberrant levels of Ang-2 and five angiogenic miRNAs (miR-27a, miR-126, miR-132, miR-223, miR-326), compared to healthy persons and patients with diabetic nephropathy. +other 33355649 hsa-mir-27a Cognition Disorders RESULTS Older patients reaching ESRD showed an unfavorable angiogenic profile, as indicated by aberrant levels of Ang-2 and five angiogenic miRNAs (miR-27a, miR-126, miR-132, miR-223, miR-326), compared to healthy persons and patients with diabetic nephropathy. +other 33355649 hsa-mir-29a Kidney Failure, Chronic Moreover, Ang-2 associated with SVD and with the domains of psychomotor speed and executive function, while miR-223 and miR-29a associated with memory function. +other 33355649 hsa-mir-29a Cognition Disorders Moreover, Ang-2 associated with SVD and with the domains of psychomotor speed and executive function, while miR-223 and miR-29a associated with memory function. +other 33355649 hsa-mir-27a Kidney Failure, Chronic RESULTS Older patients reaching ESRD showed an unfavorable angiogenic profile, as indicated by aberrant levels of Ang-2 and five angiogenic miRNAs (miR-27a, miR-126, miR-132, miR-223, miR-326), compared to healthy persons and patients with diabetic nephropathy. +other 33355649 hsa-mir-223 Kidney Failure, Chronic RESULTS Older patients reaching ESRD showed an unfavorable angiogenic profile, as indicated by aberrant levels of Ang-2 and five angiogenic miRNAs (miR-27a, miR-126, miR-132, miR-223, miR-326), compared to healthy persons and patients with diabetic nephropathy. +other 33355649 hsa-mir-326 Kidney Failure, Chronic RESULTS Older patients reaching ESRD showed an unfavorable angiogenic profile, as indicated by aberrant levels of Ang-2 and five angiogenic miRNAs (miR-27a, miR-126, miR-132, miR-223, miR-326), compared to healthy persons and patients with diabetic nephropathy. +other 33355649 hsa-mir-132 Kidney Failure, Chronic RESULTS Older patients reaching ESRD showed an unfavorable angiogenic profile, as indicated by aberrant levels of Ang-2 and five angiogenic miRNAs (miR-27a, miR-126, miR-132, miR-223, miR-326), compared to healthy persons and patients with diabetic nephropathy. +other 33355649 hsa-mir-132 Cognition Disorders RESULTS Older patients reaching ESRD showed an unfavorable angiogenic profile, as indicated by aberrant levels of Ang-2 and five angiogenic miRNAs (miR-27a, miR-126, miR-132, miR-223, miR-326), compared to healthy persons and patients with diabetic nephropathy. +other 33355649 hsa-mir-126 Kidney Failure, Chronic RESULTS Older patients reaching ESRD showed an unfavorable angiogenic profile, as indicated by aberrant levels of Ang-2 and five angiogenic miRNAs (miR-27a, miR-126, miR-132, miR-223, miR-326), compared to healthy persons and patients with diabetic nephropathy. +lncRNA target 33355622 hsa-mir-338 Lung Neoplasms 5p inhibited METTL3 expression by qPCR, western blot analysis, and luciferase reporter assay, while upregulation of METTL3 alleviated the role of miR +lncRNA target 33355365 hsa-mir-223 Colorectal Neoplasms The present study aimed to investigate the effect and mechanism of miR223 inhibiting FBXW7 on the proliferation and apoptosis of CRC cells. Thus, the present study demonstrated that miR223 could bind to the FBXW7 gene and inhibit its expression, ultimately increasing the proliferation and preventing the apoptosis of CRC cells through the Notch and Akt/mTOR signalling pathways. +other 33355363 hsa-mir-4698 Stomach Neoplasms Upregulated miR4698 and downregulated MTUS1 were identified in GC tissues and cells. +transcription factor target 33355167 hsa-mir-9 Cicatrix, Hypertrophic 5p suppressed proliferation and promoted apoptosis of HS fibroblasts by targeting PPARbeta. +other 33354568 hsa-let-7d Acquired Immunodeficiency Syndrome We also found that the miRNA let-7d-5p was downregulated in 9 INRs but only in 2 IRs by more than 2-fold. In summary, these results demonstrate for the first time that a large proportion of miRNAs are downregulated in INRs compared with IRs, and the miRNA let-7d-5p is a potential biomarker for INRs. +other 33354435 hsa-mir-21 Heart Diseases miR-21, a small microRNA, promotes the activation of CFs, leading to cardiac fibrosis. By blocking with the cardiac fibrosis miRNA miR-21, we found that miR-21 was associated with G2/M blockade in the cell cycle and was mainly involved in regulating extracellular matrix-related genes, including Grem1, Clu, Gdf15, Ccl7, and Cxcl1. +genetics_overexpression_promote 33354435 hsa-mir-21 Fibrosis miR-21 is overexpressed after irradiation; however, the relationship between increased miR-21 and myocardial fibrosis after irradiation is unclear. +genetics_overexpression_promote 33354435 hsa-mir-21 Cardiomyopathies miR-21 is overexpressed after irradiation; however, the relationship between increased miR-21 and myocardial fibrosis after irradiation is unclear. +lncRNA target 33354317 hsa-mir-193 Pulmonary Arterial Hypertension 3p reduced cell proliferation, migration, and apoptosis of PAH in vitro and pulmonary vascular remodeling in PAH in vivo through downregulating PAK4. +transcription factor target 33354277 hsa-mir-506 Testicular Diseases CONCLUSIONS: This study provided evidence that miR3p could aggravate the DBP-treated testicular oxidative stress injury in vivo and in vitro by inhibiting ANXA5 expression and downregulating Nrf2/HO-1 signaling pathway, which might provide novel understanding in DBP-induced testicular injury therapy. +transcription factor target 33354202 hsa-mir-16 Leukemia The toxin upregulated expression of the pro-apoptotic genes BID and FADD and downregulated DFFA expression in leukemic cell lines, as well as increased miR-16 expression - whose major predicted target is the anti-apoptotic gene BCL2 - in Bcr-Abl(+) cells. +other 33353431 hsa-mir-590 Lymphoma, B-Cell 5p, and miR-106b-5p increase patients' risk levels for OS. +other 33353431 hsa-mir-186 Lymphoma, B-Cell 5p, and miR-106b-5p increase patients' risk levels for OS. +other 33353431 hsa-mir-423 Lymphoma, B-Cell 5p, and miR-106b-5p increase patients' risk levels for OS. +other 33353431 hsa-mir-374b Lymphoma, B-Cell 5p, and miR-106b-5p increase patients' risk levels for OS. +other 33353431 hsa-mir-106b Lymphoma, B-Cell 5p, and miR-106b-5p increase patients' risk levels for OS. +other 33353431 hsa-mir-130a Lymphoma, B-Cell 5p, and miR-106b-5p increase patients' risk levels for OS. +lncRNA target 33353065 hsa-mir-124 Hepatitis C, Chronic Taken together, these results indicate that the RUNXOR-RUNX1-STAT3-miR124 axis enhances the differentiation and suppressive functions of MDSCs and could be a potential target for immunomodulation in conjunction with antiviral therapy during chronic HCV infection. +exosome 33353065 hsa-mir-124 Hepatitis C Mechanistically, we discovered that HCV-associated exosomes (HCV-Exo) can induce the expressions of RUNXOR and RUNX1, which in turn regulates miR-124 expression via STAT3 signaling, thereby promoting MDSC differentiation and suppressive functions. Taken together, these results indicate that the RUNXOR-RUNX1-STAT3-miR124 axis enhances the differentiation and suppressive functions of MDSCs and could be a potential target for immunomodulation in conjunction with antiviral therapy during chronic HCV infection. +other 33352965 hsa-mir-132 Chemical and Drug Induced Liver Injury, Chronic MiR-132 has emerged as a mediator of inflammation in chronic liver diseases. +other 33352947 hsa-mir-375 Heart Diseases This workflow was applied to study the functional role of miR-375 in the heart muscle (myocardium), since this miRNA was previously shown to be associated with heart diseases, and data on its function in the myocardium are mostly unclear. +circulation_biomarker_diagnosis_up 33352935 hsa-mir-1307 Carcinoma, Hepatocellular Our results show that circulating exo-miR5p promotes metastasis and helps predict metastasis in HCC, and SEC14L2 and ENG are target tumor suppressor genes of miR-1307 that promote EMT. +other 33352510 hsa-mir-381 Breast Neoplasms Moreover, we verified that miR3p expression was low and inversely correlated with PTTG1 expression in breast cancer tissues. +circulation_biomarker_prognosis_up 33352502 hsa-mir-193a Colorectal Neoplasms The expression of miR-193a in the PTM group was lower than that of the primary CRC group, and the expression of let-7g was higher than that of the primary CRC. Our study confirmed the possibility of using this as a diagnostic and prognostic marker for colorectal cancer by measuring the expression levels of exosomal miR-193a and let-7g in blood. +circulation_biomarker_prognosis_up 33352502 hsa-let-7g Colorectal Neoplasms The expression of miR-193a in the PTM group was lower than that of the primary CRC group, and the expression of let-7g was higher than that of the primary CRC. Our study confirmed the possibility of using this as a diagnostic and prognostic marker for colorectal cancer by measuring the expression levels of exosomal miR-193a and let-7g in blood. +circulation_biomarker_prognosis_up 33352502 hsa-mir-193a Peritoneal Neoplasms The expression of miR-193a in the PTM group was lower than that of the primary CRC group, and the expression of let-7g was higher than that of the primary CRC. Our study confirmed the possibility of using this as a diagnostic and prognostic marker for colorectal cancer by measuring the expression levels of exosomal miR-193a and let-7g in blood. +circulation_biomarker_prognosis_up 33352502 hsa-let-7g Peritoneal Neoplasms The expression of miR-193a in the PTM group was lower than that of the primary CRC group, and the expression of let-7g was higher than that of the primary CRC. Our study confirmed the possibility of using this as a diagnostic and prognostic marker for colorectal cancer by measuring the expression levels of exosomal miR-193a and let-7g in blood. +lncRNA target 33352501 hsa-mir-214 Nasopharyngeal Carcinoma CONCLUSIONS: The present study demonstrates the possible molecular mechanism that the down-regulated LTF enhances the radiosensitivity of NPC cells through interaction with DUSP1, PPARGC1A, FOS and SMARCA1, and miR-214 as its superior negative regulator may play a role in regulating the radiotherapy effect. +other 33351694 hsa-mir-198 Osteosarcoma Conclusions: circ_0002060 promoted DOX resistance and OS progression by regulating the miR-198/ABCB1 axis, suggesting that circ_0002060 might be a promising biomarker for OS therapy. +transcription factor target 33351232 hsa-mir-221 Coronary Artery Disease 3p induced by UVB targeted FOS 3'UTR, which played an important role in regulating proliferation and apoptosis of keratinocytes via Bcl-xL/Bax pathway; this may provide a new insight for CAD proliferative lesions. +circulation_biomarker_diagnosis_up 33350781 hsa-mir-25 Pancreatic Carcinoma To identify serum microRNA-25 (miR-25) as a diagnostic biomarker for pancreatic cancer (PCa) and to evaluate its supplementary role with serum carbohydrate antigen 19-9 (CA19-9) in early identification of cancers.Eighty patients with pancreatic cancer and 91 non-cancer controls were enrolled in this study. +other 33350775 hsa-mir-21 Carcinoma, Ovarian Epithelial This meta-analysis aimed to synthesize available data to clarify the association between microRNA-21 expression levels and clinical prognosis in EOC patients. CONCLUSION: The findings of this systematic review will show the effect of high expression of microRNA-21 on the prognosis of EOC patients. +genetics_knock down_suppress 33350586 hsa-let-7i Lung Neoplasms After loss- and gain-of-function assays, the effects of let-7i, KDM3A, DCLK1 and FXYD3 on the biological characteristics of lung cancer cells were assessed. +other 33350463 hsa-mir-34a Fatty Liver Moreover, several studies have demonstrated the association between microRNAs (miRNAs) and FLD, in which miR-122, miR-34a and miR-192 were recognized as the most relevant miRNAs as biomarkers for FLD. +other 33350463 hsa-mir-122 Fatty Liver Moreover, several studies have demonstrated the association between microRNAs (miRNAs) and FLD, in which miR-122, miR-34a and miR-192 were recognized as the most relevant miRNAs as biomarkers for FLD. +other 33350463 hsa-mir-192 Fatty Liver Moreover, several studies have demonstrated the association between microRNAs (miRNAs) and FLD, in which miR-122, miR-34a and miR-192 were recognized as the most relevant miRNAs as biomarkers for FLD. +lncRNA target 33350453 hsa-mir-27b Urinary Bladder Neoplasms CONCLUSIONS: In conclusion, engrailed-2 is engaged in the development and process of bladder cancer through the negative mediation of microRNA-27b; additionally, microRNA-27b/engrailed-2 could form a signalling pathway with a significant effect on the process of bladder cancer. +genetics_overexpression_promote 33350095 hsa-mir-3180 Carcinoma, Non-Small-Cell Lung Overexpression of miR +other 33349227 hsa-mir-145 Colorectal Neoplasms CONCLUSION: In conclusion, hsa-miR-20a and hsa-miR-145, as potential tissue-specific biomarkers for distinguishing RC and CC, improve realizing the molecular differences between these local tumors. +other 33349227 hsa-let-7g Colorectal Neoplasms RESULTS: The significantly elevated levels of miR-21, miR-133b, miR-18a, miR-20a, and miR-135b, and decreased levels of miR-34a, miR-200c, miR-145, and let-7g were detected in colorectal tumors compared to the healthy tissues (P<0.05). +other 33349227 hsa-mir-20a Colorectal Neoplasms CONCLUSION: In conclusion, hsa-miR-20a and hsa-miR-145, as potential tissue-specific biomarkers for distinguishing RC and CC, improve realizing the molecular differences between these local tumors. +other 33349227 hsa-mir-21 Colorectal Neoplasms RESULTS: The significantly elevated levels of miR-21, miR-133b, miR-18a, miR-20a, and miR-135b, and decreased levels of miR-34a, miR-200c, miR-145, and let-7g were detected in colorectal tumors compared to the healthy tissues (P<0.05). +other 33349227 hsa-mir-135b Colorectal Neoplasms RESULTS: The significantly elevated levels of miR-21, miR-133b, miR-18a, miR-20a, and miR-135b, and decreased levels of miR-34a, miR-200c, miR-145, and let-7g were detected in colorectal tumors compared to the healthy tissues (P<0.05). +other 33349227 hsa-mir-133b Colorectal Neoplasms RESULTS: The significantly elevated levels of miR-21, miR-133b, miR-18a, miR-20a, and miR-135b, and decreased levels of miR-34a, miR-200c, miR-145, and let-7g were detected in colorectal tumors compared to the healthy tissues (P<0.05). +other 33349227 hsa-mir-34a Colorectal Neoplasms RESULTS: The significantly elevated levels of miR-21, miR-133b, miR-18a, miR-20a, and miR-135b, and decreased levels of miR-34a, miR-200c, miR-145, and let-7g were detected in colorectal tumors compared to the healthy tissues (P<0.05). +other 33349227 hsa-mir-18a Colorectal Neoplasms RESULTS: The significantly elevated levels of miR-21, miR-133b, miR-18a, miR-20a, and miR-135b, and decreased levels of miR-34a, miR-200c, miR-145, and let-7g were detected in colorectal tumors compared to the healthy tissues (P<0.05). +other 33349227 hsa-mir-200c Colorectal Neoplasms RESULTS: The significantly elevated levels of miR-21, miR-133b, miR-18a, miR-20a, and miR-135b, and decreased levels of miR-34a, miR-200c, miR-145, and let-7g were detected in colorectal tumors compared to the healthy tissues (P<0.05). +lncRNA target 33349156 hsa-mir-148a Carcinoma, Hepatocellular In conclusion, our results shown the oncogenic role of KCNQ1OT1 in HCC by regulating the miR-148a-3p/IGF1R axis and may provide a new insight and a potential therapeutic target for HCC. +lncRNA target 33349155 hsa-mir-124 Stomach Neoplasms 5p inhibited the GC cell proliferation and metastasis phenotypes through MIEN1, which probably becomes a novel molecular target for clinical GC treatment. +transcription factor target 33349067 hsa-mir-21 Chemical and Drug Induced Liver Injury The hepatoprotective mechanism of GBE against MTX-induced hepatotoxicity via the modulation of the IL-6/STAT3 signaling pathway and the downregulation of the miRNA-21 hepatic expression was reported for the first time. +other 33348707 hsa-mir-181c Glioblastoma MiR-181 Family Modulates Osteopontin in Glioblastoma Multiforme. +other 33348707 hsa-mir-181d Glioblastoma MiR-181 Family Modulates Osteopontin in Glioblastoma Multiforme. +other 33348707 hsa-mir-181a Glioblastoma MiR-181 Family Modulates Osteopontin in Glioblastoma Multiforme. +other 33348707 hsa-mir-181b Glioblastoma MiR-181 Family Modulates Osteopontin in Glioblastoma Multiforme. +other 33348062 hsa-mir-216a Osteoarthritis Furthermore, we verified the functional role of sEV miR-216a-5p in the OA cartilage repair process. +other 33348053 hsa-mir-486 Liver Cirrhosis Our results showed that T-MSCs attenuate HSC activation and liver fibrosis by delivering sEVs, and miR-486 in the sEVs inactivates hedgehog signaling, suggesting that T-MSCs and their sEVs are novel anti-fibrotic therapeutics for treating chronic liver disease. +other 33347859 hsa-mir-181a Malnutrition Our findings enumerated that miR-181a, involved in lipid metabolism, was found to be downregulated in the liver of MNR offspring at 1 day of age when compared to that of control offspring. In adults, the MNR offspring elucidated increased TG content, decreased expression of miR-181a, and increased expressions levels of SIRT1, FOXO1, KLF6, and PPARgamma in liver tissues. +genetics_overexpression_suppress 33347836 hsa-mir-1323 Pneumonia, Mycoplasma MPP patients showed lower mir-1323 level in blood samples than healthy controls. The pathogenesis of MPP inhibits the expression of miR-1323 in macrophages, triggers the overexpression of Il6, and enhances inflammation response. +circulation_biomarker_diagnosis_ns 33347535 hsa-mir-615 Colorectal Neoplasms 5p in the cytoplasm of CRC cells, and decreased miR +other 33347533 hsa-mir-20b Acute Lung Injury We found that miR-20b was significantly decreased in the lung tissues of HALI models and H2O2-treated ACE IIs. These results provided new insights into the involvement of the miR-20b/MFN1/2 signaling pathway in HALI. +lncRNA target 33346094 hsa-mir-424 Carcinoma, Hepatocellular CONCLUSION: CASC9 promoted proliferation, invasion and migration and inhibited apoptosis in HCC cells by inhibiting miR +genetics_overexpression_promote 33345719 hsa-mir-129 Esophageal Squamous Cell Carcinoma 5p overexpression repressed cell cycle progression, proliferation, migration, invasion, and promoted the apoptosis in ESCC cells. +other 33345445 hsa-mir-105 Breast Neoplasms In human breast tumors, RAGC protein levels are inversely correlated with miR-105 in the stroma. +other 33345414 hsa-mir-199 Hepatitis C "There were significant upregulation of MiR-199 and significant downregulation of miR-448 in late stages of fibrosis with high diagnostic accuracy (area under the curve ""AUC"" = 0.989%; P < .001) and (AUC = 0.0.672; P > .001), respectively. CONCLUSION miR-199 and miR-448 could serve as valuable non-invasive biomarkers for assessment of liver fibrosis progression." +circulation_biomarker_diagnosis_ns 33345414 hsa-mir-448 Hepatitis C Therefore, miR-199 and miR-448 serum levels should be considered during the treatment of HCV genotype-4 patients in Egypt and the world. +lncRNA target 33345272 hsa-mir-124 Retinoblastoma CONCLUSIONS: These findings implied that KCNQ1OT1 silencing inhibited RB progression and activated SIRT1/JNK signaling pathway partially by modulating the miR-124/SP1 axis. +target gene 33344773 hsa-mir-188 Carcinoma, Non-Small-Cell Lung Downregulation of lncRNA FGF12-AS2 suppresses the tumorigenesis of NSCLC via sponging miR-188-3p. +genetics_overexpression_suppress 33344699 hsa-mir-34a Depression In conclusion, hippocampal miR-34a overexpression was a typical feature in depression-like animals, and miR-34a downregulation exerts antidepressant-like effects by restoring the spine morphology through its target synaptotagmin-1. +other 33344664 hsa-mir-132 invasive aspergillosis Several of them were previously reported in the pathogenesis of fungal infections including miR-132. +lncRNA target 33344634 hsa-mir-508 Colorectal Neoplasms 5p and enhancing RAB14 expression, which provides a therapeutic target in CRC treatment. +genetics_GWAS 33344485 hsa-mir-206 Uterine Cervical Neoplasms This study aims to investigate the prognostic value of family with sequence similarity 83, member A (FAM83A) gene and miR-206 in promoting CC progression and the involved genetic signaling pathways. Conclusion: The miR-206/FAM83A/PI3K/AKT signaling pathway possibly serves as a critical effector in CC progression indicating the potential prognostic value of FAM83A gene as a novel biomarker for CC progression. +target gene 33344462 hsa-mir-16-1 Breast Neoplasms MicroRNA-16-1-3p Represses Breast Tumor Growth and Metastasis by Inhibiting PGK1-Mediated Warburg Effect. +target gene 33344451 hsa-mir-20a Non-alcoholic Fatty Liver Disease MicroRNA-20a-5p Ameliorates Non-alcoholic Fatty Liver Disease via Inhibiting the Expression of CD36. +genetics_knock down_suppress 33344445 hsa-mir-526b Uterine Cervical Neoplasms Through experiments including loss-function and overexpression, the biological effects of circAMOTL1 and miR-526b on the proliferation, migration, apoptosis, and tumorigenicity were explored in cervical carcinomas. +lncRNA target 33344226 hsa-mir-631 Carcinoma, Hepatocellular In sum, our study first demonstrated that miR-631 targeted PTPRE to inhibit intrahepatic metastasis in HCC. +genetics_knock down_promote 33344223 hsa-mir-25 Squamous Cell Carcinoma of Head and Neck 5p knockdown exhibited the opposite effects in OSCC cells. +lncRNA target 33343806 hsa-mir-208a Shock, Hemorrhagic CONCLUSION: Calhex-231 exhibits outstanding potential for effective therapy of traumatic hemorrhagic shock, and the beneficial effects result from its protection of vascular function via inhibition of oxidative stress and miR-208a-mediated mitochondrial fission. +circulation_biomarker_prognosis_ns 33343663 hsa-mir-620 Carcinoma, Non-Small-Cell Lung RESULTS: Exosomal miR-620 was significantly reduced in NSCLC and early-stage NSCLC patients (P < 0.0001) when compared to that of healthy controls, with an area under the curve (AUC) of 0.728 and 0.707, respectively. CONCLUSION: These findings suggest the serum exosomal miR-620 as a promising diagnostic and prognostic noninvasive biomarker in NSCLC patients. +other 33343622 hsa-mir-1291 Breast Neoplasms Further studies are warranted to investigate the use of miR-1291 as a surrogate biomarker of SLN node metastasis in patients with early-stage breast cancer. +circulation_biomarker_diagnosis_ns 33342777 hsa-mir-145 Breast Neoplasms CONCLUSIONS: We observed an existing association between the molecular characteristics of BC and levels of circulating miR-133a-3p and miR +circulation_biomarker_diagnosis_ns 33342777 hsa-mir-148b Breast Neoplasms 5p, and miR-133a-3p in serum samples from 27 breast cancer (BC) and 17 benign breast tumor patients. +other 33342777 hsa-mir-133a Breast Neoplasms In addition, BC patients with either ductal carcinoma or positive molecular diagnosis for estrogen receptor, progesterone receptor, luminal A, or Her2 negative, presented a decreased expression of miR-133a-3p. +other 33342410 hsa-mir-200b Endometrial Neoplasms CONCLUSION: The Wnt signaling is disrupted in endometrial cancer, which may be due to miR 3p and miR-200b-5p activity. +other 33342410 hsa-mir-31 Endometrial Neoplasms CONCLUSION: The Wnt signaling is disrupted in endometrial cancer, which may be due to miR 3p and miR-200b-5p activity. +lncRNA target 33342344 hsa-mir-7 Nasopharyngeal Carcinoma 5p inhibited the sensitivity of NPC cells to radiation therapy, thereby suppressing ENO2 expression. +genetics_overexpression_suppress 33342146 hsa-mir-191 Stomach Neoplasms Furthermore, overexpression of miR +transcription factor target 33342075 hsa-mir-150 Liver Cirrhosis 5p attenuate HF by inhibiting the CXCL1 expression. +lncRNA target 33342041 hsa-mir-455 Ovarian Neoplasms 5p, both of which restrained the expression of E2F2 gene in ovarian cancer cells via mRNA targeting. +lncRNA target 33342041 hsa-mir-491 Ovarian Neoplasms 5p, both of which restrained the expression of E2F2 gene in ovarian cancer cells via mRNA targeting. +lncRNA target 33341669 hsa-mir-106b Sepsis CONCLUSION: All the data revealed that matrine can alleviate sepsis-related cardiac dysfunction by enhancing cardiac myoblast viability and attenuating inflammatory responses through the PTENP1/miR-106b-5p axis. +lncRNA target 33341286 hsa-mir-7 Osteosarcoma 5p, which then targeted IRS2 in OS cells. +other 33341052 hsa-mir-29b Carcinoma, Hepatocellular The anti-HCC effect of BJO and BE-BJO was intimately associated with the activation of miRNA-29b, p53-associated apoptosis and mitochondrial-related pathways. +lncRNA target 33341002 hsa-mir-150 Arthritis In summary, our findings demonstrated that MALAT1 promoted pro-inflammatory cytokine and MMP production by targeting the miR5p/ZBTB4 axis through JAK/STAT signaling pathway in sJIA, suggesting that MALAT1 may have a potential diagnostic biomarker for the pathogenesis and therapy of sJIA. +genetics_knock down_promote 33340658 hsa-mir-214 Gallbladder Neoplasms E2F3 was demonstrated to be the target gene of miR-214/-3120, and its knockdown in part mimicked the effect of miR-214/-3120 on the EMT, autophagy, tumorigenicity, and metastatic behavior of GBC-SD cells. +other 33340250 hsa-mir-520c Carcinoma, Non-Small-Cell Lung We demonstrated that miR-520c-3p and miR-1274b were significantly and steadily increased in NSCLC patients in comparison with healthy controls and benign nodule patients (P < 0.001) and decreased markedly after tumour resection (P < 0.001). In conclusion, miR-520c-3p and miR-1274b have biomarker potential for early diagnosis of NSCLC in multiple centres. +other 33340250 hsa-mir-1274b Carcinoma, Non-Small-Cell Lung We demonstrated that miR-520c-3p and miR-1274b were significantly and steadily increased in NSCLC patients in comparison with healthy controls and benign nodule patients (P < 0.001) and decreased markedly after tumour resection (P < 0.001). In conclusion, miR-520c-3p and miR-1274b have biomarker potential for early diagnosis of NSCLC in multiple centres. +transcription factor target 33340248 hsa-mir-146a Retinoblastoma MiR-146a was found inhibited the viability, proliferation and invasion of retinoblastoma cell by MTT, EdU, and transwell assays. +other 33340231 hsa-mir-10b Breast Neoplasms Systematic studies on differentiation of oncogenic miR-10b expression levels in non-malignant breast cells, metastatic breast cancer cells as well as non-metastatic breast cancer cells were then realized by this nanotool accompanied by assessment of different drugs effects. +circulation_biomarker_diagnosis_ns 33339419 hsa-mir-142 Atherosclerosis Taken together, these data suggest that plasma levels of miR-142, miR-223, miR-155, and miR-92a can significantly predict CVEs among PAD patients with good accuracy, and that plasma levels of miR-142 can be an independent biomarker to predict post-surgery CVEs development in PAD patients. +circulation_biomarker_diagnosis_ns 33339419 hsa-mir-142 Peripheral Arterial Disease Taken together, these data suggest that plasma levels of miR-142, miR-223, miR-155, and miR-92a can significantly predict CVEs among PAD patients with good accuracy, and that plasma levels of miR-142 can be an independent biomarker to predict post-surgery CVEs development in PAD patients. +other 33339419 hsa-mir-223 Peripheral Arterial Disease Intra-surgery atherosclerotic plaques from femoral arteries were collected and the levels of miR-142, miR-223, miR-155, and miR-92a of the primary transcripts of these microRNAs (pri-miRNAs), and gene expression of Drosha and Dicer were determined. +other 33339419 hsa-mir-223 Atherosclerosis Intra-surgery atherosclerotic plaques from femoral arteries were collected and the levels of miR-142, miR-223, miR-155, and miR-92a of the primary transcripts of these microRNAs (pri-miRNAs), and gene expression of Drosha and Dicer were determined. +other 33339419 hsa-mir-92a Atherosclerosis Intra-surgery atherosclerotic plaques from femoral arteries were collected and the levels of miR-142, miR-223, miR-155, and miR-92a of the primary transcripts of these microRNAs (pri-miRNAs), and gene expression of Drosha and Dicer were determined. +other 33339419 hsa-mir-92a Peripheral Arterial Disease Intra-surgery atherosclerotic plaques from femoral arteries were collected and the levels of miR-142, miR-223, miR-155, and miR-92a of the primary transcripts of these microRNAs (pri-miRNAs), and gene expression of Drosha and Dicer were determined. +other 33339419 hsa-mir-155 Peripheral Arterial Disease Intra-surgery atherosclerotic plaques from femoral arteries were collected and the levels of miR-142, miR-223, miR-155, and miR-92a of the primary transcripts of these microRNAs (pri-miRNAs), and gene expression of Drosha and Dicer were determined. +other 33339419 hsa-mir-155 Atherosclerosis Intra-surgery atherosclerotic plaques from femoral arteries were collected and the levels of miR-142, miR-223, miR-155, and miR-92a of the primary transcripts of these microRNAs (pri-miRNAs), and gene expression of Drosha and Dicer were determined. +genetics_overexpression_promote 33339069 hsa-mir-127 Thyroid Cancer, Papillary Moreover, overexpression of miR-127 significantly enhanced cell proliferation, migration, and invasion of PTC by targeting REPIN1. +other 33338854 hsa-mir-34a Mesothelioma In the present study, miR-16 and miR-34a were transfected, singularly and in combination, in MPM cell lines H2052 and H28, and their effects on cell proliferation and sensitivity to cisplatin are reported. Consequently, although the potential of miR-16 and miR-34a is confirmed, we must conclude that their combination does not improve the response of MPM to chemotherapy. +other 33338854 hsa-mir-16 Mesothelioma In the present study, miR-16 and miR-34a were transfected, singularly and in combination, in MPM cell lines H2052 and H28, and their effects on cell proliferation and sensitivity to cisplatin are reported. Consequently, although the potential of miR-16 and miR-34a is confirmed, we must conclude that their combination does not improve the response of MPM to chemotherapy. +transcription factor target 33338580 hsa-mir-29c Liver Diseases These findings suggest that hsa-miR-19a-3p and hsa-miR-29c-3p significantly suppressed expression of the S gene, offering potential therapeutic targets for treating patients with HBV infection, and further reducing the negative impact of HBV infection on sperm fertilizing capacity. +transcription factor target 33338580 hsa-mir-19a Liver Diseases These findings suggest that hsa-miR-19a-3p and hsa-miR-29c-3p significantly suppressed expression of the S gene, offering potential therapeutic targets for treating patients with HBV infection, and further reducing the negative impact of HBV infection on sperm fertilizing capacity. +circulation_biomarker_diagnosis_up 33337849 hsa-mir-124 Stomach Neoplasms 3p, and their combination can serve as serum-based biomarkers to predict the therapeutic benefit of DDP in GC. +circulation_biomarker_diagnosis_up 33337849 hsa-mir-3180 Stomach Neoplasms 3p, and their combination can serve as serum-based biomarkers to predict the therapeutic benefit of DDP in GC. +lncRNA target 33337350 hsa-mir-486 Colorectal Neoplasms In conclusion, NEAT1 stimulated colorectal cancer progression via acting as competing endogenous RNA to sponge miR +lncRNA target 33337348 hsa-mir-26a Carcinoma, Renal Cell CONCLUSION: Our results indicate that the dysregulation of miR-15a-5p and -26a-5p contribute cooperatively to the proliferation of ccRCC through their regulation of OGT. +lncRNA target 33337348 hsa-mir-15a Carcinoma, Renal Cell CONCLUSION: Our results indicate that the dysregulation of miR-15a-5p and -26a-5p contribute cooperatively to the proliferation of ccRCC through their regulation of OGT. +lncRNA target 33336871 hsa-mir-141 Glioma The rescue assays confirmed that inhibiting linc00475 restrained the progression of glioma through the miR +lncRNA target 33336851 hsa-mir-758 Osteoporosis IA regulated osteoblast apoptosis through XIST/miR +lncRNA target 33336785 hsa-mir-182 Cataract OBJECTIVE: The aim of this study was to investigate the influences of micro ribonucleic acid (miR)-182 on oxidative stress and epithelial cell apoptosis in the lens of cataract rats through the phosphatidylinositol 3-hydroxy kinase/protein kinase B (PI3K/Akt) pathway. CONCLUSIONS: MiR-182 inhibits oxidative stress and epithelial cell apoptosis in the lens of cataract rats by activating the PI3K/Akt signaling pathway. +circulation_biomarker_diagnosis_up 33336764 hsa-mir-636 Atherosclerosis CONCLUSIONS: According to the results, we found that circPTPRA was upregulated in serum samples of AS patients, which promoted cell proliferation and inhibited cell apoptosis through repressing miR-636 and upregulating SP1 signaling axis. +lncRNA target 33336753 hsa-mir-130b Brain Ischemia CONCLUSIONS: Taken together, our results suggested that miR-130b facilitated cell viability and suppressed cell apoptosis of CIR via negatively regulating of IRF1. +other 33336744 hsa-mir-942 Glioma 5p / MAT2A axis is responsible for the deterioration of glioma. +lncRNA target 33336743 hsa-mir-18a Glioma RESULTS: Compared with adjacent non-cancerous normal tissues, SET7/9 and DRAIC were both downregulated and miR-18a-3p was upregulated in glioma cells. CONCLUSIONS: In this research, we discovered that the expression of SET7/9 was low in glioma cells and SET7/9-mediated H3K4me3 enrichment on the DRAIC promoter regulated the growth and metastasis of glioma cells by targeting miR-18a-3p. +genetics_overexpression_suppress 33336742 hsa-mir-198 Thyroid Neoplasms MicroRNA-198 and H3F3A overexpression models were constructed using lentivirus in TCa cell lines TPC-1 and BHP2-7, and the impacts of microRNA-198 on TCa cell functions were evaluated by using cell counting kit-8 (CCK-8), plate clone formation, and transwell assays. +genetics_overexpression_promote 33336738 hsa-mir-199a Laryngeal Neoplasms RESULTS: The qRT-PCR results revealed that miR-199a-5p was significantly lowly expressed in the laryngeal cancer tissues and tumor cell lines, and overexpression of miR-199a-5p substantially inhibited the proliferation of HEp-2 cells. +lncRNA target 33336734 hsa-mir-137 Pancreatic Carcinoma CONCLUSIONS To sum up, these results proposed that XIST functioned as an endogenous sponge in promoting PC cell proliferation through competing for miR-137 to regulate Notch1 expression, and may provide more therapeutic targets for the patients with PC. +lncRNA target 33336733 hsa-mir-7 Carcinoma, Hepatocellular OBJECTIVE: This study aimed to observe the effect of microRNA-7 on the proliferation and migration of human hepatocellular carcinoma cell line SMMC-7721 and its effect on epithelial-mesenchymal transition (EMT). CONCLUSIONS: The miR-7 can inhibit the proliferation and invasion of human hepatocellular carcinoma cell line SMMC-7721, and its mechanism may be related to upregulation of E-cadherin, beta-catenin protein, and downregulation of N-cadherin and Vimentin proteins. +lncRNA target 33336731 hsa-mir-196 Carcinoma, Hepatocellular CONCLUSIONS: MAFG-AS1 facilitated the progression of HCC via targeting miR-3196/OTX1 axis, which might be used as a new insight for HCC treatment. +genetics_overexpression_promote 33336729 hsa-mir-1231 Gallbladder Neoplasms Notably, overexpression of FOXC2 abolished regulatory effects of overexpressed miR-1231 on proliferative and apoptotic potentials in GBC cells. +genetics_knock down_promote 33336726 hsa-mir-361 Retinoblastoma CONCLUSIONS: We demonstrated that circ_0000034 knockdown suppressed the development of RB by the modulation of miR +lncRNA target 33336724 hsa-mir-150 Lymphoma, Mantle-Cell CONCLUSIONS: MiR-150 inhibits the proliferation and promotes the apoptosis of MCL cells by negatively regulating MET expression. +target gene 33336718 hsa-mir-200a Pancreatic Neoplasms Long noncoding RNA SOX2OT maintains the stemness of pancreatic cancer cells by regulating DEK via interacting with miR-200a/141. +target gene 33336718 hsa-mir-141 Pancreatic Neoplasms Long noncoding RNA SOX2OT maintains the stemness of pancreatic cancer cells by regulating DEK via interacting with miR-200a/141. +circulation_biomarker_diagnosis_ns 33336524 hsa-mir-129 Coronary Disease In summary, elevated serum miR +circulation_biomarker_diagnosis_up 33336518 hsa-mir-409 Cerebral Infarction, Acute Altogether, elevated plasma miR +other 33336500 hsa-mir-18a Thyroid Neoplasms Upregulation of FIH-1 abrogated the promotive effect of miR-18a-5p on the growth and invasion of thyroid cancer cells. These data elucidated the CASC2/miR-18a-5p ceRNA network in thyroid cancer pathogenesis. +other 33336412 hsa-mir-155 Periodontitis CONCLUSIONS Diabetes- and periodontitis-induced increase in microRNA-146a and -155 in oral cavity is predicted to upregulate angiotensin-converting enzyme 2 expression, essential SARS-CoV-2 entry receptors, and modulate host antiviral response. +other 33336412 hsa-mir-146a Diabetes Mellitus, Type 2 CONCLUSIONS Diabetes- and periodontitis-induced increase in microRNA-146a and -155 in oral cavity is predicted to upregulate angiotensin-converting enzyme 2 expression, essential SARS-CoV-2 entry receptors, and modulate host antiviral response. +other 33336412 hsa-mir-146a Periodontitis CONCLUSIONS Diabetes- and periodontitis-induced increase in microRNA-146a and -155 in oral cavity is predicted to upregulate angiotensin-converting enzyme 2 expression, essential SARS-CoV-2 entry receptors, and modulate host antiviral response. +other 33336412 hsa-mir-155 Diabetes Mellitus, Type 2 CONCLUSIONS Diabetes- and periodontitis-induced increase in microRNA-146a and -155 in oral cavity is predicted to upregulate angiotensin-converting enzyme 2 expression, essential SARS-CoV-2 entry receptors, and modulate host antiviral response. +lncRNA target 33336275 hsa-mir-221 high grade glioma The aim of this chapter is to describe methods for the efficient delivery of unmodified PNAs designed to target microRNAs involved in cancer, using as model system miR3p and human glioma cells as in vitro experimental cellular system. +genetics_knock down_promote 33336076 hsa-mir-135a Nasopharyngeal Carcinoma Our results suggested that miR-135a-5p upregulation inhibited NPC cell growth, enhanced cell apoptosis, promoted Caspase3 activity, increased cleaved-Caspase3, and reduced pro-Caspase3 level. To sum up, our data showed that FOXD3-AS1 knockdown regulated cell growth and apoptosis in NCP cells via altering miR-135a-5p expression, suggesting that FOXD3-AS1 might be a therapeutic target for NPC diagnosis and treatment. +circRNA target 33336062 hsa-mir-182 Pre-Eclampsia CONCLUSION: Hsa_circ_0007121 mediated the progression of PE via miR +lncRNA target 33336058 hsa-mir-1294 Stomach Neoplasms NEAT1 could modulate cell proliferation, apoptosis, and metastasis in GC cells by regulating the PI3K/AKT/mTOR signaling pathway via the miR-1294/AKT1 axis, showing the great potential for NEAT1 as a valid biomarker in the progression and treatment of GC. +target gene 33336057 hsa-mir-200b Uterine Cervical Neoplasms Effect of miRNA-200b on the proliferation and apoptosis of cervical cancer cells by targeting RhoA. +genetics_overexpression_promote 33336052 hsa-mir-155 Breast Neoplasms 5p overexpression. +lncRNA target 33336050 hsa-mir-506 Glioma In conclusion, our data suggested that FOXD2-AS1 contributed to glioma proliferation, metastasis and EMT via competitively binding to miR +lncRNA target 33336045 hsa-mir-1225 Glioblastoma 5p to inhibit glioblastoma cell viability, invasion and migration was at least partially achieved by targeting FNDC3B. +lncRNA target 33336030 hsa-mir-204 Squamous Cell Carcinoma of Head and Neck 5p may be involved in the progression of SCCHN through EMT-related biological process and energy balance related AMPK signaling pathway, respectively. +lncRNA target 33336030 hsa-mir-223 Squamous Cell Carcinoma of Head and Neck 5p may be involved in the progression of SCCHN through EMT-related biological process and energy balance related AMPK signaling pathway, respectively. +other 33336000 hsa-mir-101 Carcinoma, Non-Small-Cell Lung miR-101-3p sensitizes non-small cell lung cancer cells to irradiation. +lncRNA target 33335994 hsa-mir-22 Sepsis CONCLUSION: Depletion of NEAT1 alleviated sepsis-induced AKI via regulating the miR3p/NF-kappaB pathway. +lncRNA target 33335994 hsa-mir-22 Acute Kidney Injury CONCLUSION: Depletion of NEAT1 alleviated sepsis-induced AKI via regulating the miR3p/NF-kappaB pathway. +target gene 33335853 hsa-mir-100 Prostatic Neoplasms miR-100-5p Downregulates mTOR to Suppress the Proliferation, Migration, and Invasion of Prostate Cancer Cells. +other 33335800 hsa-mir-122a Liver Neoplasms To confer potent anti-HCC effects and minimize hepatotoxicity, we constructed post-transcriptionally enhanced ribozyme constructs coupled with splicing donor and acceptor site and woodchuck hepatitis virus post-transcriptional regulatory element under the control of microRNA-122a (miR-122a). +exosome 33335797 hsa-mir-145 Atherosclerosis rich exosomes have great potential for atherosclerosis prevention. +genetics_overexpression_promote 33335754 hsa-mir-142 Spinal Cord Injuries The results suggested that overexpression of miR +other 33335585 hsa-mir-146a Inflammation Islet cells exposed to inflammation exhibited markedly downregulated protein levels of transcription factor MafA, pancreatic and duodenal homeobox 1, paired box 6, homeobox protein Nkx-2.2, synaptosomal-associated protein 25, glucagon and insulin-2, while the expression of miR-146a-5p and miR-21a-5p were upregulated. +other 33335585 hsa-mir-21 Inflammation Islet cells exposed to inflammation exhibited markedly downregulated protein levels of transcription factor MafA, pancreatic and duodenal homeobox 1, paired box 6, homeobox protein Nkx-2.2, synaptosomal-associated protein 25, glucagon and insulin-2, while the expression of miR-146a-5p and miR-21a-5p were upregulated. Particularly, miR-21a-5p upregulation in response to inflammation may contribute to islet cell dysfunction. +lncRNA target 33335585 hsa-mir-21 Insulinoma The downregulation of islet functional factor mRNA was partially reversed by treating islet cells with an inhibitor of miR-21a-5p. Particularly, miR-21a-5p upregulation in response to inflammation may contribute to islet cell dysfunction. +other 33335583 hsa-mir-4793 primary biliary cholangitis 1 3p could be a feasible indicator for bacterial infection in patients with HBV-LC, and it would be valuable for further research. +genetics_overexpression_promote 33335579 hsa-mir-451a Carcinoma, Squamous Cell, Cutaneous Overexpression of miR-451a was demonstrated to impair the proliferation, migration, invasion and epithelial-mesenchymal transition (EMT), and promoted apoptosis in cSCC cells by interacting with PDPK1, possibly by direct targeting. +transcription factor target 33335572 hsa-mir-335 Osteoarthritis 5P mediated the development of OA by targeting the HBP1 gene and promoting chondrocyte apoptosis. +lncRNA target 33335569 hsa-mir-218 Carcinoma, Non-Small-Cell Lung In conclusion, the present results suggested that miR-218 downregulated glucose metabolism in NSCLC not only by directly targeting GLUT1, but also via the NF-kappaB signaling pathway. +other 33335404 hsa-mir-622 Colorectal Neoplasms CONCLUSION: Our study revealed the role of the circ_GLG1-miRKRAS axis in CRC. +other 33334882 hsa-mir-559 Dysautonomia, Familial miR3P and miR-6324 increased gradually after FFT. +other 33334882 hsa-mir-6324 Dysautonomia, Familial miR3P and miR-6324 increased gradually after FFT. +other 33334367 hsa-mir-1 Urinary Bladder Neoplasms CONCLUSIONS Our study demonstrates that MIR31HG and its splice variants could serve as biomarkers for the classification and prognosis prediction of patients with MIBC. +circulation_biomarker_diagnosis_up 33334303 hsa-mir-122 Hepatitis C, Chronic Since the lower levels of circulating miR-122 were observed in the LTC group compared to the CHC group, advanced liver damages might reduce the release of miR-122 from the hepatocytes, as a sign of liver function deficiency. +genetics_GWAS 33333886 hsa-mir-124 Lymphoma, T-Cell, Cutaneous CONCLUSIONS: Our study highlights the importance of the miR-124/STAT3 axis in CTCL and demonstrates that the STAT3 pathway is regulated through epigenetic mechanisms in these cells. +genetics_knock down_promote 33333383 hsa-mir-1236 Breast Neoplasms 3p, and CHD4 elevation reversed the inhibitory effect of circ_0006528 knockdown on ADM-resistant BCa cells. +transcription factor target 33333289 hsa-mir-103a Multiple Organ Failure Targeted binding between miR-103a-3p and HMGB1 was verified by a double luciferase assay and their roles in LPS-induced sepsis were further explored using gain-of-function experiments. +transcription factor target 33333289 hsa-mir-103a Sepsis Targeted binding between miR-103a-3p and HMGB1 was verified by a double luciferase assay and their roles in LPS-induced sepsis were further explored using gain-of-function experiments. +transcription factor target 33333129 hsa-mir-623 Intervertebral disc disease Herein, miR-623 showed to be downregulated within IDD tissue samples according to both bioinformatics and experimental analyses. In contrast to miR-623, CXCL12 expression was significantly upregulated in IDD tissues; miR-623 directly bound CXCL12 to inhibit its expression. +lncRNA target 33333053 hsa-mir-424 Liver Cirrhosis SIGNIFICANCE: miR-322/424 plays a central role in the pathogenesis of liver fibrosis by targeting Cullin2, and enhancing HIF-1alpha-mediated hepatic angiogenesis. +lncRNA target 33333053 hsa-mir-22 Liver Cirrhosis SIGNIFICANCE: miR-322/424 plays a central role in the pathogenesis of liver fibrosis by targeting Cullin2, and enhancing HIF-1alpha-mediated hepatic angiogenesis. +lncRNA target 33332780 hsa-mir-590 Diabetic Neuropathies 3p ameliorates DPNP via targeting RAP1A and inhibiting T cells infiltration, indicating that exogenous miR +other 33332758 hsa-mir-223 Colitis MicroRNA-233 (miR-223) might be involved in the development of IBD; however, the mechanism underlying its pathogenesis is unclear. These findings provide evidence that miR-223 might have potential therapeutic implications in IBD. +other 33332758 hsa-mir-223 Inflammatory Bowel Diseases MicroRNA-233 (miR-223) might be involved in the development of IBD; however, the mechanism underlying its pathogenesis is unclear. These findings provide evidence that miR-223 might have potential therapeutic implications in IBD. +genetics_overexpression_promote 33332750 hsa-mir-425 Myocarditis Overexpressed miR +genetics_knock down_suppress 33332749 hsa-mir-19b Bone Diseases These results indicated that miR-19b-3p was involved in bone loss after SCI by inhibiting osteogenesis via PTEN/Akt/mTOR signalling pathway. +genetics_knock down_suppress 33332749 hsa-mir-19b Spinal Cord Injuries These results indicated that miR-19b-3p was involved in bone loss after SCI by inhibiting osteogenesis via PTEN/Akt/mTOR signalling pathway. +genetics_overexpression_promote 33332746 hsa-mir-637 Multiple Myeloma Overexpression of NUPR1 reversed the effects of miR-637 mimics in MM cells. +lncRNA target 33332731 hsa-mir-10a Ovarian Neoplasms These observations suggested that miR-10a-5p suppressed the aggressive phenotypes of OC cells via regulating HOXA1. +genetics_overexpression_promote 33332708 hsa-mir-21 Nasopharyngeal Carcinoma The results suggested that MEG3 overexpression in HK-1 cells up-regulated PTEN and down-regulated miR-21, by which MEG3 further inhibited autophagy and apoptosis ability of NPC cells. +genetics_overexpression_promote 33332541 hsa-mir-195 Lung Neoplasms 5p was lowly expressed in human LUAD cells, and its overexpression markedly suppressed cell proliferation, migration, and invasion and increased the apoptosis of LUAD cells in vitro. +lncRNA target 33332475 hsa-mir-29 Fibrosis Our recent work showed that dysregulation of miR-29 contributes to the formation of cardiac fibrosis in animal models of uremic cardiomyopathy, whereas replenishing miR-29 attenuated cardiac fibrosis in these animals. In summary, our work demonstrated that the Col1a1-miR-29b vector can be used as a dynamic regulator of collagen and other ECM protein expression in response to fibrotic stimulation, which could potentially reduce unnecessary side effect due to excessive miR-29b levels while remaining an effective potential therapeutic approach for fibrosis. +transcription factor target 33332475 hsa-mir-29 Cardiomyopathies Our recent work showed that dysregulation of miR-29 contributes to the formation of cardiac fibrosis in animal models of uremic cardiomyopathy, whereas replenishing miR-29 attenuated cardiac fibrosis in these animals. +other 33332475 hsa-mir-29b Fibrosis In summary, our work demonstrated that the Col1a1-miR-29b vector can be used as a dynamic regulator of collagen and other ECM protein expression in response to fibrotic stimulation, which could potentially reduce unnecessary side effect due to excessive miR-29b levels while remaining an effective potential therapeutic approach for fibrosis. +transcription factor target 33332475 hsa-mir-29 Diabetic Cardiomyopathies Our recent work showed that dysregulation of miR-29 contributes to the formation of cardiac fibrosis in animal models of uremic cardiomyopathy, whereas replenishing miR-29 attenuated cardiac fibrosis in these animals. +lncRNA target 33332077 hsa-mir-21 Reperfusion Injury, Pulmonary Ischemia Taken together, Dex treatment attenuated ischemia-reperfusion induced pulmonary injury through modulating the miR +other 33331954 hsa-mir-181b Prostatic Hyperplasia 5p and especially miR-200b-3p and miR-181b-5p may differentiate BPH and PC. +other 33331954 hsa-mir-200b Prostatic Neoplasms The expression of miR-200b-3p was significantly higher in cancerous prostate: both in adenocarcinomatous glands and in the adjacent, apparently unaffected glands compared to BPH samples. +other 33331954 hsa-mir-200b Prostatic Hyperplasia The expression of miR-200b-3p was significantly higher in cancerous prostate: both in adenocarcinomatous glands and in the adjacent, apparently unaffected glands compared to BPH samples. +other 33331954 hsa-mir-181b Prostatic Neoplasms 5p and especially miR-200b-3p and miR-181b-5p may differentiate BPH and PC. +circulation_biomarker_diagnosis_ns 33331738 hsa-mir-203 Diabetic Nephropathies AIM The aim of this study was to evaluate changes in the serum levels of miR-98, miR-184, miR-185, miR-203 and miR-196a-3p in type 2 diabetes mellitus (T2DM) patients with diabetic nephropathy (DN) and to associate the changes in microRNA levels with urinary albumin excretion (UAE). CONCLUSIONS Increased serum levels of miR-203 and miR-196a-3p are independent risk factors of UAE which is a marker of DN. +circulation_biomarker_diagnosis_ns 33331738 hsa-mir-184 Diabetic Nephropathies AIM The aim of this study was to evaluate changes in the serum levels of miR-98, miR-184, miR-185, miR-203 and miR-196a-3p in type 2 diabetes mellitus (T2DM) patients with diabetic nephropathy (DN) and to associate the changes in microRNA levels with urinary albumin excretion (UAE). +circulation_biomarker_diagnosis_ns 33331738 hsa-mir-98 Diabetic Nephropathies AIM The aim of this study was to evaluate changes in the serum levels of miR-98, miR-184, miR-185, miR-203 and miR-196a-3p in type 2 diabetes mellitus (T2DM) patients with diabetic nephropathy (DN) and to associate the changes in microRNA levels with urinary albumin excretion (UAE). +circulation_biomarker_diagnosis_ns 33331738 hsa-mir-196a Diabetic Nephropathies AIM The aim of this study was to evaluate changes in the serum levels of miR-98, miR-184, miR-185, miR-203 and miR-196a-3p in type 2 diabetes mellitus (T2DM) patients with diabetic nephropathy (DN) and to associate the changes in microRNA levels with urinary albumin excretion (UAE). CONCLUSIONS Increased serum levels of miR-203 and miR-196a-3p are independent risk factors of UAE which is a marker of DN. +other 33331537 hsa-mir-181a Leukemia In the present study, Trdmt1 was up-regulated and miR-181a was down-regulated significantly during human leukemia HL-60 cell differentiation after TAT-CT3 fusion protein treatment. +genetics_overexpression_promote 33331071 hsa-mir-139 Atherosclerosis 5p and overexpressed EHZ2 and STAT1 were found in AS. +other 33330483 hsa-mir-665 Ovarian Neoplasms CircASH2L Promotes Ovarian Cancer Tumorigenesis, Angiogenesis, and Lymphangiogenesis by Regulating the miR-665/VEGFA Axis as a Competing Endogenous RNA. +exosome 33330451 hsa-mir-16 Stomach Neoplasms 5p in exosomes. +target gene 33330445 hsa-mir-124 Neuroblastoma miR-124-3p direct targeting and repression of key up-regulated cytoskeletal genes including MYH9, ACTN4 and PLEC and the reversal of the resistance-associated EMT and enhanced invasive capacity +genetics_knock down_suppress 33330080 hsa-mir-34a Breast Neoplasms Functional loss experiments showed that the repressive effect of SNHG7 knockdown on BC cell stemness was partially reversed by transfection with miR-34a inhibitors. In summary, this study indicated that SNHG7 contributed to the chemoresistance of BC and mediated chemoresistance and cancer stemness by sponging miR-34a. +other 33330077 hsa-mir-29c Squamous Cell Carcinoma of Head and Neck In oral cancer cells, MCP-1 increased VEGF-A expression and subsequently promoted angiogenesis; miR-29c mimic reversed MCP-1 activity. +genetics_overexpression_promote 33330073 hsa-mir-613 Triple Negative Breast Neoplasms In vivo study revealed that overexpression of miR +lncRNA target 33330021 hsa-mir-877 Squamous Cell Carcinoma of Head and Neck 3p inhibitor reversed the inhibitory effect of si-hsa_circ_0001766 on expression of VEGFA and proliferation of OSCC cells. +circulation_biomarker_diagnosis_ns 33329742 hsa-mir-4687 Carcinoma, Non-Small-Cell Lung Serum MiR-4687-3p Has Potential for Diagnosis and Carcinogenesis in Non-small Cell Lung Cancer. +other 33329702 hsa-mir-138 Down Syndrome Known functional molecules in DS or neurodegeneration (e.g., miR-138, OLIG1, and TPM2) were also included in this network. +lncRNA target 33328976 hsa-mir-101 Parkinson Disease All in all, lncRNA-T199678 mitigated the alpha-Syn-induced dopaminergic neuron injury via targeting miR3p, which contributed to promote PD. +circulation_biomarker_diagnosis_up 33328767 hsa-mir-139 Uterine Cervical Neoplasms 5p was negatively correlated with serum ZEB1. +genetics_knock down_promote 33328759 hsa-mir-452 Carcinoma, Non-Small-Cell Lung Circular RNA 0001313 Knockdown Suppresses Non-Small Cell Lung Cancer Cell Proliferation and Invasion via the microRNA-452/HMGB3/ERK/MAPK Axis. +lncRNA target 33328586 hsa-mir-448 Carcinoma, Hepatocellular dependent inhibition of DOT1L may delay the progression of HCC by restraining self-renewal capability of HCC stem cells, representing novel targets for HCC management. +exosome 33328510 hsa-mir-124 Hepatitis C LncRNA HOTAIRM1 promotes MDSC expansion and suppressive functions through the HOXA1-miR124 axis during HCV infection. We show that HCV-associated exosomes (HCV-Exo) can modulate HOTAIRM1, HOXA1, and miR124 expressions to regulate MDSC development. +lncRNA target 33328510 hsa-mir-124 Virus Diseases In essence, these results indicate that the HOTAIRM1-HOXA1-miR124 axis enhances the differentiation and suppressive functions of MDSCs and may be a potential target for immunomodulation in conjunction with antiviral therapy during chronic viral infection. +lncRNA target 33328388 hsa-mir-376b Acute Kidney Injury Interestingly, miR-376b suppressed the expression of NF-kappaB inhibitor zeta (NFKBIZ) in both in vitro and in vivo models of septic AKI. +other 33328386 hsa-mir-18a Acute Kidney Injury Finally, we used our data-driven approach to rationally select macrophage-enriched miR5p and miR-18a-5p and demonstrate that they are promising urinary biomarkers of acute kidney injury in renal transplant recipients. +other 33328386 hsa-mir-16 Acute Kidney Injury Finally, we used our data-driven approach to rationally select macrophage-enriched miR5p and miR-18a-5p and demonstrate that they are promising urinary biomarkers of acute kidney injury in renal transplant recipients. +circulation_biomarker_diagnosis_up 33328332 hsa-mir-375 Osteochondrodysplasias In sum, our study indicates that the circulating exosomal miR +genetics_overexpression_promote 33327965 hsa-mir-4310 Glioma Overexpressed miR-4310 promoted glioma cell proliferation, migration, and invasion in vitro, as well as tumorigenesis in vivo. +lncRNA target 33327962 hsa-mir-181b Adenocarcinoma of Lung Targeting ST7-AS1 and KPNA4 or up-regulating miR-181b-5p, therefore, may benefit the treatment of LUAD. +circulation_biomarker_diagnosis_up 33327889 hsa-mir-766 Uterine Cervical Neoplasms ROC curve suggested that serum miR +lncRNA target 33327879 hsa-mir-199a Carcinoma, Hepatocellular In conclusion, miR-199a-3p was down regulated in HCC and LAMA4 may be a potential target of miR-199a-3p in HCC. +lncRNA target 33327874 hsa-mir-146b Squamous Cell Carcinoma of Head and Neck Co-inhibition of HBP1 reversed the suppressive impact of miR-146b inhibition on OSCC cell proliferation, migration, and invasion. +circulation_biomarker_prognosis_ns 33327871 hsa-mir-205 Squamous Cell Carcinoma of Head and Neck 5p in the plasma of patients with HNSCC. +circulation_biomarker_prognosis_ns 33327867 hsa-mir-125b Uterine Cervical Neoplasms CONCLUSIONS: Combining serum miR-21, miR-125b and miR-370 as a miRNA-based signature is promising for the detection and prognosis prediction of early-stage CC. +circulation_biomarker_diagnosis_ns 33327867 hsa-mir-21 Uterine Cervical Neoplasms RESULTS: Compared to the patients with CIN and healthy subjects, serum miR-21 was increased, while serum miR-125b and serum miR-370 were reduced in early-stage CC. +circulation_biomarker_prognosis_ns 33327867 hsa-mir-370 Uterine Cervical Neoplasms CONCLUSIONS: Combining serum miR-21, miR-125b and miR-370 as a miRNA-based signature is promising for the detection and prognosis prediction of early-stage CC. +lncRNA target 33327804 hsa-mir-204 Polycystic Ovary Syndrome "CONCLUSIONS: Our findings reveal that MALAT1 may regulate EMT, proliferation, and migration of LECs as a ceRNA by ""sponging"" miR5p and targeting Smad4, and serve as a promising therapeutic target in preventing PCO." +target gene 33327491 hsa-mir-221 Breast Neoplasms MEK1 Inhibitor Combined with Irradiation Reduces Migration of Breast Cancer Cells Including miR-221 and ZEB1 EMT Marker Expression. +other 33327422 hsa-mir-181b Hematologic Neoplasms RESULTS: Our results indicated potential feasibility of (i) differentiating ALL+AML from a nontumor hematopoietic pathology with 93% sensitivity and 92% specificity using miR-150:miR-21, miR-20a:miR-221, and miR-24:nf3 (where nf3 is a normalization factor calculated from threshold cycle values of miR-103a, miR-191, and miR-378); (ii) diagnosing ALL with 81% sensitivity and 81% specificity using miR-181b:miR-100, miR-223:miR-124, and miR-24:nf3; and (iii) diagnosing AML with 81% sensitivity and 84% specificity using miR-150:miR-221, miR-100:miR-24, and miR-181a:miR-191. +other 33327422 hsa-mir-181b Leukemia, Acute RESULTS: Our results indicated potential feasibility of (i) differentiating ALL+AML from a nontumor hematopoietic pathology with 93% sensitivity and 92% specificity using miR-150:miR-21, miR-20a:miR-221, and miR-24:nf3 (where nf3 is a normalization factor calculated from threshold cycle values of miR-103a, miR-191, and miR-378); (ii) diagnosing ALL with 81% sensitivity and 81% specificity using miR-181b:miR-100, miR-223:miR-124, and miR-24:nf3; and (iii) diagnosing AML with 81% sensitivity and 84% specificity using miR-150:miR-221, miR-100:miR-24, and miR-181a:miR-191. +other 33327422 hsa-mir-103a Leukemia, Acute RESULTS: Our results indicated potential feasibility of (i) differentiating ALL+AML from a nontumor hematopoietic pathology with 93% sensitivity and 92% specificity using miR-150:miR-21, miR-20a:miR-221, and miR-24:nf3 (where nf3 is a normalization factor calculated from threshold cycle values of miR-103a, miR-191, and miR-378); (ii) diagnosing ALL with 81% sensitivity and 81% specificity using miR-181b:miR-100, miR-223:miR-124, and miR-24:nf3; and (iii) diagnosing AML with 81% sensitivity and 84% specificity using miR-150:miR-221, miR-100:miR-24, and miR-181a:miR-191. +other 33327422 hsa-mir-223 Hematologic Neoplasms RESULTS: Our results indicated potential feasibility of (i) differentiating ALL+AML from a nontumor hematopoietic pathology with 93% sensitivity and 92% specificity using miR-150:miR-21, miR-20a:miR-221, and miR-24:nf3 (where nf3 is a normalization factor calculated from threshold cycle values of miR-103a, miR-191, and miR-378); (ii) diagnosing ALL with 81% sensitivity and 81% specificity using miR-181b:miR-100, miR-223:miR-124, and miR-24:nf3; and (iii) diagnosing AML with 81% sensitivity and 84% specificity using miR-150:miR-221, miR-100:miR-24, and miR-181a:miR-191. +other 33327422 hsa-mir-103a Hematologic Neoplasms RESULTS: Our results indicated potential feasibility of (i) differentiating ALL+AML from a nontumor hematopoietic pathology with 93% sensitivity and 92% specificity using miR-150:miR-21, miR-20a:miR-221, and miR-24:nf3 (where nf3 is a normalization factor calculated from threshold cycle values of miR-103a, miR-191, and miR-378); (ii) diagnosing ALL with 81% sensitivity and 81% specificity using miR-181b:miR-100, miR-223:miR-124, and miR-24:nf3; and (iii) diagnosing AML with 81% sensitivity and 84% specificity using miR-150:miR-221, miR-100:miR-24, and miR-181a:miR-191. +other 33327422 hsa-mir-100 Hematologic Neoplasms RESULTS: Our results indicated potential feasibility of (i) differentiating ALL+AML from a nontumor hematopoietic pathology with 93% sensitivity and 92% specificity using miR-150:miR-21, miR-20a:miR-221, and miR-24:nf3 (where nf3 is a normalization factor calculated from threshold cycle values of miR-103a, miR-191, and miR-378); (ii) diagnosing ALL with 81% sensitivity and 81% specificity using miR-181b:miR-100, miR-223:miR-124, and miR-24:nf3; and (iii) diagnosing AML with 81% sensitivity and 84% specificity using miR-150:miR-221, miR-100:miR-24, and miR-181a:miR-191. +other 33327422 hsa-mir-24 Hematologic Neoplasms RESULTS: Our results indicated potential feasibility of (i) differentiating ALL+AML from a nontumor hematopoietic pathology with 93% sensitivity and 92% specificity using miR-150:miR-21, miR-20a:miR-221, and miR-24:nf3 (where nf3 is a normalization factor calculated from threshold cycle values of miR-103a, miR-191, and miR-378); (ii) diagnosing ALL with 81% sensitivity and 81% specificity using miR-181b:miR-100, miR-223:miR-124, and miR-24:nf3; and (iii) diagnosing AML with 81% sensitivity and 84% specificity using miR-150:miR-221, miR-100:miR-24, and miR-181a:miR-191. +other 33327422 hsa-mir-181a Hematologic Neoplasms RESULTS: Our results indicated potential feasibility of (i) differentiating ALL+AML from a nontumor hematopoietic pathology with 93% sensitivity and 92% specificity using miR-150:miR-21, miR-20a:miR-221, and miR-24:nf3 (where nf3 is a normalization factor calculated from threshold cycle values of miR-103a, miR-191, and miR-378); (ii) diagnosing ALL with 81% sensitivity and 81% specificity using miR-181b:miR-100, miR-223:miR-124, and miR-24:nf3; and (iii) diagnosing AML with 81% sensitivity and 84% specificity using miR-150:miR-221, miR-100:miR-24, and miR-181a:miR-191. +other 33327422 hsa-mir-181a Leukemia, Acute RESULTS: Our results indicated potential feasibility of (i) differentiating ALL+AML from a nontumor hematopoietic pathology with 93% sensitivity and 92% specificity using miR-150:miR-21, miR-20a:miR-221, and miR-24:nf3 (where nf3 is a normalization factor calculated from threshold cycle values of miR-103a, miR-191, and miR-378); (ii) diagnosing ALL with 81% sensitivity and 81% specificity using miR-181b:miR-100, miR-223:miR-124, and miR-24:nf3; and (iii) diagnosing AML with 81% sensitivity and 84% specificity using miR-150:miR-221, miR-100:miR-24, and miR-181a:miR-191. +other 33327422 hsa-mir-20a Hematologic Neoplasms RESULTS: Our results indicated potential feasibility of (i) differentiating ALL+AML from a nontumor hematopoietic pathology with 93% sensitivity and 92% specificity using miR-150:miR-21, miR-20a:miR-221, and miR-24:nf3 (where nf3 is a normalization factor calculated from threshold cycle values of miR-103a, miR-191, and miR-378); (ii) diagnosing ALL with 81% sensitivity and 81% specificity using miR-181b:miR-100, miR-223:miR-124, and miR-24:nf3; and (iii) diagnosing AML with 81% sensitivity and 84% specificity using miR-150:miR-221, miR-100:miR-24, and miR-181a:miR-191. +other 33327422 hsa-mir-221 Leukemia, Acute RESULTS: Our results indicated potential feasibility of (i) differentiating ALL+AML from a nontumor hematopoietic pathology with 93% sensitivity and 92% specificity using miR-150:miR-21, miR-20a:miR-221, and miR-24:nf3 (where nf3 is a normalization factor calculated from threshold cycle values of miR-103a, miR-191, and miR-378); (ii) diagnosing ALL with 81% sensitivity and 81% specificity using miR-181b:miR-100, miR-223:miR-124, and miR-24:nf3; and (iii) diagnosing AML with 81% sensitivity and 84% specificity using miR-150:miR-221, miR-100:miR-24, and miR-181a:miR-191. +other 33327422 hsa-mir-378 Hematologic Neoplasms RESULTS: Our results indicated potential feasibility of (i) differentiating ALL+AML from a nontumor hematopoietic pathology with 93% sensitivity and 92% specificity using miR-150:miR-21, miR-20a:miR-221, and miR-24:nf3 (where nf3 is a normalization factor calculated from threshold cycle values of miR-103a, miR-191, and miR-378); (ii) diagnosing ALL with 81% sensitivity and 81% specificity using miR-181b:miR-100, miR-223:miR-124, and miR-24:nf3; and (iii) diagnosing AML with 81% sensitivity and 84% specificity using miR-150:miR-221, miR-100:miR-24, and miR-181a:miR-191. +other 33327422 hsa-mir-21 Hematologic Neoplasms RESULTS: Our results indicated potential feasibility of (i) differentiating ALL+AML from a nontumor hematopoietic pathology with 93% sensitivity and 92% specificity using miR-150:miR-21, miR-20a:miR-221, and miR-24:nf3 (where nf3 is a normalization factor calculated from threshold cycle values of miR-103a, miR-191, and miR-378); (ii) diagnosing ALL with 81% sensitivity and 81% specificity using miR-181b:miR-100, miR-223:miR-124, and miR-24:nf3; and (iii) diagnosing AML with 81% sensitivity and 84% specificity using miR-150:miR-221, miR-100:miR-24, and miR-181a:miR-191. +other 33327422 hsa-mir-21 Leukemia, Acute RESULTS: Our results indicated potential feasibility of (i) differentiating ALL+AML from a nontumor hematopoietic pathology with 93% sensitivity and 92% specificity using miR-150:miR-21, miR-20a:miR-221, and miR-24:nf3 (where nf3 is a normalization factor calculated from threshold cycle values of miR-103a, miR-191, and miR-378); (ii) diagnosing ALL with 81% sensitivity and 81% specificity using miR-181b:miR-100, miR-223:miR-124, and miR-24:nf3; and (iii) diagnosing AML with 81% sensitivity and 84% specificity using miR-150:miR-221, miR-100:miR-24, and miR-181a:miR-191. +other 33327422 hsa-mir-100 Leukemia, Acute RESULTS: Our results indicated potential feasibility of (i) differentiating ALL+AML from a nontumor hematopoietic pathology with 93% sensitivity and 92% specificity using miR-150:miR-21, miR-20a:miR-221, and miR-24:nf3 (where nf3 is a normalization factor calculated from threshold cycle values of miR-103a, miR-191, and miR-378); (ii) diagnosing ALL with 81% sensitivity and 81% specificity using miR-181b:miR-100, miR-223:miR-124, and miR-24:nf3; and (iii) diagnosing AML with 81% sensitivity and 84% specificity using miR-150:miR-221, miR-100:miR-24, and miR-181a:miR-191. +other 33327422 hsa-mir-221 Hematologic Neoplasms RESULTS: Our results indicated potential feasibility of (i) differentiating ALL+AML from a nontumor hematopoietic pathology with 93% sensitivity and 92% specificity using miR-150:miR-21, miR-20a:miR-221, and miR-24:nf3 (where nf3 is a normalization factor calculated from threshold cycle values of miR-103a, miR-191, and miR-378); (ii) diagnosing ALL with 81% sensitivity and 81% specificity using miR-181b:miR-100, miR-223:miR-124, and miR-24:nf3; and (iii) diagnosing AML with 81% sensitivity and 84% specificity using miR-150:miR-221, miR-100:miR-24, and miR-181a:miR-191. +other 33327422 hsa-mir-124 Hematologic Neoplasms RESULTS: Our results indicated potential feasibility of (i) differentiating ALL+AML from a nontumor hematopoietic pathology with 93% sensitivity and 92% specificity using miR-150:miR-21, miR-20a:miR-221, and miR-24:nf3 (where nf3 is a normalization factor calculated from threshold cycle values of miR-103a, miR-191, and miR-378); (ii) diagnosing ALL with 81% sensitivity and 81% specificity using miR-181b:miR-100, miR-223:miR-124, and miR-24:nf3; and (iii) diagnosing AML with 81% sensitivity and 84% specificity using miR-150:miR-221, miR-100:miR-24, and miR-181a:miR-191. +other 33327422 hsa-mir-191 Leukemia, Acute RESULTS: Our results indicated potential feasibility of (i) differentiating ALL+AML from a nontumor hematopoietic pathology with 93% sensitivity and 92% specificity using miR-150:miR-21, miR-20a:miR-221, and miR-24:nf3 (where nf3 is a normalization factor calculated from threshold cycle values of miR-103a, miR-191, and miR-378); (ii) diagnosing ALL with 81% sensitivity and 81% specificity using miR-181b:miR-100, miR-223:miR-124, and miR-24:nf3; and (iii) diagnosing AML with 81% sensitivity and 84% specificity using miR-150:miR-221, miR-100:miR-24, and miR-181a:miR-191. +other 33327422 hsa-mir-24 Leukemia, Acute RESULTS: Our results indicated potential feasibility of (i) differentiating ALL+AML from a nontumor hematopoietic pathology with 93% sensitivity and 92% specificity using miR-150:miR-21, miR-20a:miR-221, and miR-24:nf3 (where nf3 is a normalization factor calculated from threshold cycle values of miR-103a, miR-191, and miR-378); (ii) diagnosing ALL with 81% sensitivity and 81% specificity using miR-181b:miR-100, miR-223:miR-124, and miR-24:nf3; and (iii) diagnosing AML with 81% sensitivity and 84% specificity using miR-150:miR-221, miR-100:miR-24, and miR-181a:miR-191. +other 33327422 hsa-mir-191 Hematologic Neoplasms RESULTS: Our results indicated potential feasibility of (i) differentiating ALL+AML from a nontumor hematopoietic pathology with 93% sensitivity and 92% specificity using miR-150:miR-21, miR-20a:miR-221, and miR-24:nf3 (where nf3 is a normalization factor calculated from threshold cycle values of miR-103a, miR-191, and miR-378); (ii) diagnosing ALL with 81% sensitivity and 81% specificity using miR-181b:miR-100, miR-223:miR-124, and miR-24:nf3; and (iii) diagnosing AML with 81% sensitivity and 84% specificity using miR-150:miR-221, miR-100:miR-24, and miR-181a:miR-191. +other 33327422 hsa-mir-378 Leukemia, Acute RESULTS: Our results indicated potential feasibility of (i) differentiating ALL+AML from a nontumor hematopoietic pathology with 93% sensitivity and 92% specificity using miR-150:miR-21, miR-20a:miR-221, and miR-24:nf3 (where nf3 is a normalization factor calculated from threshold cycle values of miR-103a, miR-191, and miR-378); (ii) diagnosing ALL with 81% sensitivity and 81% specificity using miR-181b:miR-100, miR-223:miR-124, and miR-24:nf3; and (iii) diagnosing AML with 81% sensitivity and 84% specificity using miR-150:miR-221, miR-100:miR-24, and miR-181a:miR-191. +other 33327422 hsa-mir-20a Leukemia, Acute RESULTS: Our results indicated potential feasibility of (i) differentiating ALL+AML from a nontumor hematopoietic pathology with 93% sensitivity and 92% specificity using miR-150:miR-21, miR-20a:miR-221, and miR-24:nf3 (where nf3 is a normalization factor calculated from threshold cycle values of miR-103a, miR-191, and miR-378); (ii) diagnosing ALL with 81% sensitivity and 81% specificity using miR-181b:miR-100, miR-223:miR-124, and miR-24:nf3; and (iii) diagnosing AML with 81% sensitivity and 84% specificity using miR-150:miR-221, miR-100:miR-24, and miR-181a:miR-191. +other 33327422 hsa-mir-223 Leukemia, Acute RESULTS: Our results indicated potential feasibility of (i) differentiating ALL+AML from a nontumor hematopoietic pathology with 93% sensitivity and 92% specificity using miR-150:miR-21, miR-20a:miR-221, and miR-24:nf3 (where nf3 is a normalization factor calculated from threshold cycle values of miR-103a, miR-191, and miR-378); (ii) diagnosing ALL with 81% sensitivity and 81% specificity using miR-181b:miR-100, miR-223:miR-124, and miR-24:nf3; and (iii) diagnosing AML with 81% sensitivity and 84% specificity using miR-150:miR-221, miR-100:miR-24, and miR-181a:miR-191. +other 33327422 hsa-mir-124 Leukemia, Acute RESULTS: Our results indicated potential feasibility of (i) differentiating ALL+AML from a nontumor hematopoietic pathology with 93% sensitivity and 92% specificity using miR-150:miR-21, miR-20a:miR-221, and miR-24:nf3 (where nf3 is a normalization factor calculated from threshold cycle values of miR-103a, miR-191, and miR-378); (ii) diagnosing ALL with 81% sensitivity and 81% specificity using miR-181b:miR-100, miR-223:miR-124, and miR-24:nf3; and (iii) diagnosing AML with 81% sensitivity and 84% specificity using miR-150:miR-221, miR-100:miR-24, and miR-181a:miR-191. +other 33327325 hsa-mir-203 Esophageal Squamous Cell Carcinoma CONCLUSION The findings of this meta-analysis will show the effect of high expression of microRNA-203 on the prognosis of EC patients, and may find a new prognostic marker for EC. +circulation_biomarker_prognosis_up 33327275 hsa-mir-223 Sepsis Moreover, in sepsis patients, lncRNA TUG1 expression was negatively correlated with respiratory infection, serum creatinine (Scr), white blood cell (WBC), C-reactive protein (CRP), APACHE II score, and SOFA score but positively correlated with albumin (all P<.05); miR-223 expression was negatively correlated with skin and soft tissue infection and albumin but positively correlated with Scr, WBC, CRP, APACHE II score, and SOFA score (all P<0.05). +genetics_GWAS 33326978 hsa-mir-146 Perinatal Asphyxia The microRNAs species miR124, miR132, miR134, miR146, and miR15a were measured from the hippocampus 24 h post-asphyxia, to investigate its epigenetic response to PA and maternal diet. +genetics_GWAS 33326978 hsa-mir-124 Perinatal Asphyxia The microRNAs species miR124, miR132, miR134, miR146, and miR15a were measured from the hippocampus 24 h post-asphyxia, to investigate its epigenetic response to PA and maternal diet. +genetics_GWAS 33326978 hsa-mir-134 Perinatal Asphyxia The microRNAs species miR124, miR132, miR134, miR146, and miR15a were measured from the hippocampus 24 h post-asphyxia, to investigate its epigenetic response to PA and maternal diet. +genetics_GWAS 33326978 hsa-mir-132 Perinatal Asphyxia The microRNAs species miR124, miR132, miR134, miR146, and miR15a were measured from the hippocampus 24 h post-asphyxia, to investigate its epigenetic response to PA and maternal diet. +genetics_GWAS 33326978 hsa-mir-15a Perinatal Asphyxia The microRNAs species miR124, miR132, miR134, miR146, and miR15a were measured from the hippocampus 24 h post-asphyxia, to investigate its epigenetic response to PA and maternal diet. +genetics_knock down_promote 33326930 hsa-mir-497 Esophageal Squamous Cell Carcinoma CONCLUSIONS CircDUSP16 knockdown suppressed hypoxia-induced ESCC cell growth, invasion, and glycolysis by regulating TKTL1 expression through sponging miR +lncRNA target 33326806 hsa-mir-7 Coronary Artery Disease 5p was found to own the largest number of binding sites in has_circ_0001946 sequence, and among its targets predicted, the poly ADP-ribose polymerase 1 (PARP1) has been implicated in the pathophysiology of CHD. +genetics_overexpression_promote 33326690 hsa-mir-770 Squamous Cell Carcinoma of Head and Neck Furthermore, in vivo metastasis experiments indicated that miR-770 overexpression led to more prominent OSCC metastasis and downregulated Sirt7 expression. +genetics_knock down_promote 33325210 hsa-mir-448 Glioblastoma XIST knockdown or miR-448 overexpression could dramatically inhibit GBM cell proliferation, migration, and invasion. +other 33325119 hsa-mir-490 Carcinoma, Non-Small-Cell Lung RESULTS: High expression of CCAT1 was observed in NSCLC tissues and cells, with low expression of miR-490. CONCLUSIONS: The CCAT1/miR-490 molecular axis has been shown to be important for the treatment of NSCLC. +transcription factor target 33325118 hsa-mir-223 Atherosclerosis BMSCs-MVs carried miR-223 to inhibit NLRP3 expression and reduce macrophage pyroptosis, thereby stabilizing the atherosclerotic plaques. +other 33325098 hsa-mir-192 Diabetic Retinopathy Our study established that miR-192 released by Evs from MSCs could delay the events of the inflammatory response and angiogenesis in DR and may represent a possible therapeutic approach for the treatment of DR. +circulation_biomarker_diagnosis_up 33325094 hsa-mir-486 Carcinoma, Non-Small-Cell Lung 5p was remarkably increased in serum, while dramatically downregulated in tumor tissues of NSCLC. +lncRNA target 33325089 hsa-mir-1587 Breast Neoplasms In this study, we found that M2 macrophages promoted increased cell proliferation and migration as well as reduced expression of interferon regulatory factor 7 (IRF7) and increased the expression of miR-1587 in breast cancer cells. Collectively, this study revealed that the miR-1587/IRF7 axis mediates M2 macrophage-induced breast cancer progression, and this sheds light on further clinical therapy for breast cancer by targeting TAMs as well as the miR-1587/IRF7 axis. +lncRNA target 33325083 hsa-mir-30 Nervous System Diseases Our results demonstrated that microRNA-330 sponges could sustainably suppress LPS-induced polarization of microglia both in vivo and in vitro probably by negatively regulating NF-kappaB activity via target SHIP1 in microglia, which might be a promising neuroprotective strategy in neurological diseases, such as PD. +lncRNA target 33325083 hsa-mir-30 late onset Parkinson's disease Our results demonstrated that microRNA-330 sponges could sustainably suppress LPS-induced polarization of microglia both in vivo and in vitro probably by negatively regulating NF-kappaB activity via target SHIP1 in microglia, which might be a promising neuroprotective strategy in neurological diseases, such as PD. +exosome 33324643 hsa-mir-374b Reperfusion Injury, Renal Ischemia Our studies demonstrated that exosomal miR-374b-5p played an essential role in the communication between injured TECs and macrophages, resulting in the M1 macrophage activation during RIRI. +genetics_overexpression_promote 33324395 hsa-mir-630 Glomerulonephritis, IGA In the present study, microarray analysis showed that the expression of microRNA-630 (miR-630) was significantly reduced in palatal tonsils from IgAN patients compared with chronic tonsillitis. When miR-630 was overexpressed in palatal tonsil mononuclear cells from IgAN patients, the expression of TLR4 was reduced and the content of IgA1 in the cell culture supernatant was decreased, and the level of galactosylation in the IgA1 hinge region was increased. +lncRNA target 33324345 hsa-mir-124 Non-alcoholic Fatty Liver Disease 3p/Pref-1 as potential targets for clinical interventions of NAFLD. +circulation_biomarker_diagnosis_up 33324202 hsa-mir-200b Diabetic Retinopathy Results: DM rats exhibits significantly increased blood retinal-barrier (BRB) breakdown and VEGF/VEGFR expression in the retina, and decreased miR-200b and tight junction ZO-1/Occludin/ Claudin-5 genes expression, as well as Ang-1/Tie-2 expressions in the retina compared to normal control group. LTF treatment significantly moderated histological abnormalities in diabetic rats, independent of blood glucose level; improved some hemorrheological parameters; decreased the expressions of VEGF/VEGFR and BRB breakdown, significantly increased PEDF and tight junction proteins ZO-1/Occludin, as well as increased retinal miR-200b expression compared to non-treatment diabetic rats. +target gene 33324107 hsa-mir-613 Triple Negative Breast Neoplasms miR-613 Suppresses Chemoresistance and Stemness in Triple-Negative Breast Cancer by Targeting FAM83A. +genetics_overexpression_promote 33324105 hsa-mir-20 Esophageal Squamous Cell Carcinoma Moreover, both NLIPMT and miR-320 overexpression inhibited cell proliferation and migration and promoted cell cycle arrest and apoptosis in ESCC cells, while their effects were abolished by survivin overexpression. +other 33324096 hsa-mir-326 Carcinoma, Hepatocellular In addition, circRNA_102272 facilitated HCC cisplatin-resistance by regulating the miR-326/RUNX2 axis. +genetics_knock down_promote 33324070 hsa-mir-130a Breast Neoplasms H19 Knockdown Suppresses Proliferation and Induces Apoptosis by Regulating miR-130a-3p/SATB1 in Breast Cancer Cells. +exosome 33323968 hsa-mir-23c Prostatic Neoplasms Intriguingly, FOXM1 was found to negatively regulate miR-23c expression in prostate cancer. These findings suggest a critical role of RGN in prostate cancer dormancy, and the utility of RGN signaling and exosomal miR-23c as biomarkers for predicting recurrence. +genetics_overexpression_promote 33323682 hsa-mir-138 Lung Neoplasms Taken together, we found that autophagy helped to maintain self-renewal and invasion ability of lung cancer stem-like cells and overexpressed miR +genetics_overexpression_promote 33323675 hsa-mir-361 Multiple Myeloma 3p was low expressed in the plasma of MM patients and cell lines, while its overexpression inhibited viability and colony formation of MM cells and increased the cell apoptosis. +transcription factor target 33323304 hsa-mir-424 Keloid It is worth noting that miR3p in the blue module (r = 0.98, p = 1e-18) is considered to be the ultimate target most relevant to keloid progression through co-expressed network analysis. +other 33323026 hsa-mir-1275 Myocardial Reperfusion Injury The present study aimed to assess the role of miR-1275 in cardiac ischemia reperfusion injury. +other 33323026 hsa-mir-1275 Cardiomyopathies Silence of NMUR1 abolished the protecting effect of the miR-1275 antagomir on myocardial OGD/R injury. +other 33322976 hsa-mir-708 Osteoporosis 3p were shown to originate from the same precursor miRNA and to have a synergistic effect on the development of osteoporosis with different temporal and spatial patterns. +circulation_biomarker_diagnosis_ns 33322822 hsa-mir-21 Bone Diseases Serum expression of miRNAs related to osteoblasts (miRNA-23a-3p) and osteoclasts (miRNA +circulation_biomarker_diagnosis_ns 33322822 hsa-mir-23a Bone Diseases Serum expression of miRNAs related to osteoblasts (miRNA-23a-3p) and osteoclasts (miRNA +circulation_biomarker_diagnosis_ns 33322822 hsa-mir-124 Bone Diseases Serum expression of miRNAs related to osteoblasts (miRNA-23a-3p) and osteoclasts (miRNA +lncRNA target 33322675 hsa-mir-139 Carcinoma, Renal Cell Here, 19 and 22 genes were identified as putative targets of miR +lncRNA target 33322515 hsa-mir-96 Obesity Overall, this study highlights the role of miR5p in myogenesis via FHL1 suppression and suggests a novel regulatory mechanism for myogenesis mediated by miRNA in a background of obesity. +other 33322437 hsa-mir-373 Mouth Neoplasms This study identifies the oncogenic role of the miR-371/372/373 cluster in OSCC. +other 33322437 hsa-mir-372 Mouth Neoplasms This study identifies the oncogenic role of the miR-371/372/373 cluster in OSCC. +other 33322258 hsa-mir-200c Colonic Polyps Expression of regulatory microRNAs hsa-miR-200c and hsa-miR-146a significantly negatively correlated with the expression of their regulated genes, while significant difference between AEM and AEC was observed only for hsa-miR-29c. +other 33322258 hsa-mir-146a Colonic Polyps Expression of regulatory microRNAs hsa-miR-200c and hsa-miR-146a significantly negatively correlated with the expression of their regulated genes, while significant difference between AEM and AEC was observed only for hsa-miR-29c. +other 33322258 hsa-mir-29c Colonic Polyps Expression of regulatory microRNAs hsa-miR-200c and hsa-miR-146a significantly negatively correlated with the expression of their regulated genes, while significant difference between AEM and AEC was observed only for hsa-miR-29c. +circulation_biomarker_diagnosis_ns 33321516 hsa-mir-150 Esophageal Squamous Cell Carcinoma In fatal cases, quantitative ADC histogram analyses also demonstrated different end-stage patterns between adults and children: Severe hypoxia, evidenced by global ADC decrease and elevated plasma levels of lipocalin-2 and microRNA-150, was associated with a fatal outcome in adults. +lncRNA target 33320589 hsa-mir-29 Osteosarcoma Moreover, miR-29 was obviously downregulated in soft substrate-cultured osteosarcoma cells, and the expression of stemness-related transcription factors (Sox2, Nanog, and Oct4) and the sphere formation ability were significantly inhibited by ectopic expression of miR-29b-5p. +lncRNA target 33320435 hsa-mir-1208 Carcinoma, Hepatocellular Furthermore, we demonstrated that circPUM1 could promote the development of HCC by up-regulating the expression of MAP3K2 via sponging miR-1208. +genetics_overexpression_promote 33320427 hsa-mir-488 Carcinoma, Non-Small-Cell Lung Additionally, ZNF281 overexpression and miR-488 suppression recovered the influences of repressed circ-0008003 on NSCLC cellular processes. +genetics_overexpression_promote 33320287 hsa-mir-573 Pancreatic Carcinoma Furthermore, overexpression of TSPAN1 attenuated miR +transcription factor target 33319811 hsa-mir-125b Obesity In conclusion, we show that miR-125b-2 is a novel potential target for regulating fat accumulation, and also a candidate target to develop novel treatment strategies for obesity and diabetes. +transcription factor target 33319811 hsa-mir-125b-2 Obesity In conclusion, we show that miR-125b-2 is a novel potential target for regulating fat accumulation, and also a candidate target to develop novel treatment strategies for obesity and diabetes. +transcription factor target 33319407 hsa-mir-144 Anemia Our findings also demonstrate that disruption of the miR-144/451-Myc crosstalk causes anemia, suggesting that miR-144/451 might be a potential therapeutic target in red cell diseases. +transcription factor target 33319407 hsa-mir-144 Polycythemia Our findings also demonstrate that disruption of the miR-144/451-Myc crosstalk causes anemia, suggesting that miR-144/451 might be a potential therapeutic target in red cell diseases. +genetics_GWAS 33319237 hsa-mir-499 Stomach Neoplasms In subgroup analyses, we identified that rs3746444 SNP in mir-499 increased the risk of GC in Asians and gastric cardiac adenocarcinoma (GCA) subgroups. +lncRNA target 33318617 hsa-mir-26b Leukemia, Myeloid, Acute Mechanistic studies revealed a SNHG5/miR-26b/connective tissue growth factor (CTGF)/vascular endothelial growth factor A (VEGFA) axis in the regulation of AML angiogenesis. Collectively, upregulation of lncRNA SNHG5 mediated by YY1, activates CTGF/VEGFA via targeting miR-26b to regulate angiogenesis of AML. +transcription factor target 33318569 hsa-mir-210 Diabetes Mellitus In conclusion, miR-210 accelerates wound healing specifically in diabetes through improvement of the cellular metabolism. +other 33318505 hsa-mir-85 Osteoarthritis 3p has a role in chondrocyte function and could contribute to the process of osteoarthritis. +genetics_overexpression_promote 33318473 hsa-mir-21 Colorectal Neoplasms Transcription of VMP1 activated either by small activating RNA (saRNA) or transcriptional activator GLI3 inhibited miR-21 expression through reducing its transcripts of VMP1-miR-21 and pri-miR-21, while no significant change in miR-21 expression after exogenous overexpression VMP1 in colorectal cancer cell HCT116. +genetics_GWAS 33318409 hsa-let-7a-2 Ischemic Stroke In this case-control study, we analyzed the distribution of pri-let-7a-2 variants in patients at a high risk for ischemic stroke and the interactions of pri-let-7a-2 variants and environmental factors. Therefore, the detection of pri-let-7a-2 polymorphisms may increase the awareness of ischemic stroke risk. +other 33318319 hsa-mir-668 Tuberculosis No evident difference was observed between tuberculosis and healthy control groups in terms of the expression of miR-587 and miR-668. +other 33318319 hsa-mir-488 Tuberculosis 5p. +other 33318319 hsa-mir-24 Tuberculosis 5p. +other 33318319 hsa-mir-587 Tuberculosis No evident difference was observed between tuberculosis and healthy control groups in terms of the expression of miR-587 and miR-668. +other 33318319 hsa-mir-224 Tuberculosis 5p. +genetics_overexpression_promote 33318318 hsa-mir-125b Carcinoma, Hepatocellular The apoptosis of HCC cells was promoted by CYTOR interference while inhibited by miR-125b-5p interference and KIAA1522 overexpression. +genetics_knock down_promote 33318312 hsa-mir-195 Thyroid Cancer, Papillary In short, this work demonstrates that LINC00324 knockdown inhibits the proliferation and invasion of PTC cells by decreasing TRIM29 expression via up-regulating miR +lncRNA target 33318298 hsa-mir-147a Pneumonia CONCLUSION: Deletion of MIAT protected against LPS-induced lung inflammation via regulating miR-147a/NKAP, which might provide new insight for pneumonia treatment. +circRNA target 33318297 hsa-mir-1291 Pigmentation Disorders "Hence, the ""ENST00000606533/circ_0091223-miRTYR"" ceRNA network is involved in -MSH-induced melanogenesis, and ceRNA networks may be potential therapeutic targets for skin pigmentation disorders." +other 33318191 hsa-mir-21 Triple Negative Breast Neoplasms The compound exerted selective effects on the transcriptome and selectively mitigated a miRassociated invasive phenotype in triple-negative breast cancer cells. +lncRNA target 33317921 hsa-mir-125b Inflammation All LncRNA-DANCR effects in the colitis model were reversed by the miR-125b-5p inhibitor. CONCLUSION: LncRNA-DANCR/miR-125b-5p, which may act as a regulatory axis in inflammation, apoptosis and barrier function dysregulation, can provide an essential reference for the development of new drugs in colitis treatment. +lncRNA target 33317921 hsa-mir-125b Wounds and Injuries All LncRNA-DANCR effects in the colitis model were reversed by the miR-125b-5p inhibitor. CONCLUSION: LncRNA-DANCR/miR-125b-5p, which may act as a regulatory axis in inflammation, apoptosis and barrier function dysregulation, can provide an essential reference for the development of new drugs in colitis treatment. +lncRNA target 33317757 hsa-mir-139 Breast Neoplasms 5p/ARF6 axis might be a promising target for the treatment of BC. +exosome 33317606 hsa-mir-146a Prostatic Neoplasms CONCLUSIONS: CAFs-derived exosomal miR-146a-5p confers metastasis in PCa cells under ADT through the EGFR/ERK pathway and it may present a new treatment for PCa. +lncRNA target 33317596 hsa-mir-193a Colorectal Neoplasms CONCLUSIONS CircRNA_0000392 functions as an oncogene through the miR-193a-5p/PIK3R3/Akt axis in CRC cells, suggesting that circRNA_0000392 is a potential therapeutic target for the treatment of colorectal cancer and a predictive marker for CRC patients. +other 33317572 hsa-mir-424 Ovarian Neoplasms RESULTS: MIEF2 expression was significantly increased in OC mainly due to the down-regulation of miR5p, which predicts poor survival for patients with OC. +genetics_overexpression_promote 33317407 hsa-mir-574 Nasopharyngeal Carcinoma 5p inhibitor or FOXN3 overexpression. +circulation_biomarker_prognosis_up 33317398 hsa-mir-762 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: In conclusion, serum miR-762 might serve as a promising diagnostic and prognostic biomarker for the NSCLC. +circRNA target 33316781 hsa-mir-198 Glioma Moreover, TRIM14 was a target of miR-198 and silencing of TRIM14 hindered TMZ resistance and suppressed the progression of TMZ-resistant glioma cells, while TRIM14 over-expression rescued the inhibiting effect of miR-198 over-expression. +other 33316739 hsa-mir-424 Carcinoma, Hepatocellular Abnormal expression of MiR5p has been reported to accelerate the progression of liver cancer, but it mediated immune cell infiltration imbalance is still unknown. +other 33316641 hsa-mir-503 Familial Primary Pulmonary Hypertension Possible immune regulation mechanisms in CTEPH may be circ_0022342miR5pSLC2A3 and circ_0002062miR-92b-3p/miR-92a-3pMAN2A1. +other 33316641 hsa-mir-92a Familial Primary Pulmonary Hypertension Possible immune regulation mechanisms in CTEPH may be circ_0022342miR5pSLC2A3 and circ_0002062miR-92b-3p/miR-92a-3pMAN2A1. +other 33316599 hsa-mir-26b Diabetes Mellitus miR-26b has been implicated in a wide range of human diseases, including cancer, diabetes, heart disease, Alzheimer's disease and osteoarthritis. +other 33316599 hsa-mir-26b Alzheimer Disease miR-26b has been implicated in a wide range of human diseases, including cancer, diabetes, heart disease, Alzheimer's disease and osteoarthritis. +other 33316599 hsa-mir-26b Osteoarthritis miR-26b has been implicated in a wide range of human diseases, including cancer, diabetes, heart disease, Alzheimer's disease and osteoarthritis. +other 33316599 hsa-mir-26b Heart Diseases miR-26b has been implicated in a wide range of human diseases, including cancer, diabetes, heart disease, Alzheimer's disease and osteoarthritis. +transcription factor target 33316298 hsa-mir-122 Liver Neoplasms The RNA nanoparticles carrying miR122 and PTX were delivered to the liver cancer cells efficiently due to their rubber-like property to enhance their EPR as well as the receptor-mediated endocytosis by hepatocyte targeting-ligands. +other 33316063 hsa-mir-29 Erectile Dysfunction Also, the conserved binding site of miR3p that is involved in various cancers was observed in the 3' untranslated region of genes associated with ED. +genetics_overexpression_promote 33315517 hsa-mir-17 Aortic Aneurysm, Abdominal 5p overexpression promoted the vascular repair in aneurysm rats and increased the level of EPCs in the aneurysm tissues and peripheral blood of the rats. +other 33314669 hsa-mir-29b Colorectal Neoplasms Collectively, these findings provide comprehensive evidence that RAD51-AS1 repressed cell proliferation, migration, invasion and glycolysis process, ultimately contributing to the progression of CRC by repressing the miR-29b/c-3p/NDRG2 signaling axis, insinuating the putative potential of RAD51-AS1/miR-29b/c-3p/NDRG2 interaction network in unraveling CRC pathology and hopefully contributed to the treatment of CRC patients. +other 33314662 hsa-mir-485 Dyspepsia CONCLUSIONS: Overall, these data suggested that miR-485 participated in enterodynia in PMS offspring, which is likely mediated by the enhanced ASIC1 activities. +circRNA target 33314661 hsa-mir-3150a Diabetic Foot circRNA_072697 acted as a sponge of miR-3150a-3p in the progression of DFU via regulating KRAS. +lncRNA target 33314611 hsa-mir-381 Brain Injury, Ischemic Importantly, our study demonstrated that Dex elevated the expression of miR-381, which ultimately results in the inhibition of inflammation response in rats with cerebral ischaemic injury. +lncRNA target 33314611 hsa-mir-38 Brain Injury, Ischemic Importantly, our study demonstrated that Dex elevated the expression of miR-381, which ultimately results in the inhibition of inflammation response in rats with cerebral ischaemic injury. +genetics_knock down_promote 33314408 hsa-mir-107 Squamous Cell Carcinoma of Head and Neck Moreover, HMGB1 was predicted as a target of miR-107 in LSCC cells and knockdown of HMGB1 was able to suppress autophagy and drug resistance in LSCC cells. +other 33314303 hsa-let-7a Cerebrovascular Disorders The abundance of let-7a-5p, let-7b-5p, and let-7f-5p, but not miR-130a-3p nor miR-130b-3p, was significantly higher in patients with ictal migraine compared with that of controls and patients with interictal migraine. +other 33314303 hsa-let-7f Cerebrovascular Disorders The abundance of let-7a-5p, let-7b-5p, and let-7f-5p, but not miR-130a-3p nor miR-130b-3p, was significantly higher in patients with ictal migraine compared with that of controls and patients with interictal migraine. +genetics_overexpression_promote 33314303 hsa-mir-130a Cerebrovascular Disorders RESULTS: We identified a panel of miRNAs including miR-130a-3p, miR-130b-3p, let-7a-5p, let-7b-5p, and let-7f-5p that well differentiated patients with RCVS from controls (area under the receiver operating characteristics curve [AUC] was 0.906, 0.890, and 0.867 in the 3 cohorts, respectively). Moreover, miR-130a-3p was associated with imaging-proven disruption of the blood-brain barrier (BBB) in patients with RCVS and its overexpression led to reduced transendothelial electrical resistance (ie, increased permeability) in in vitro human BBB model. +other 33314303 hsa-mir-130b Cerebrovascular Disorders The abundance of let-7a-5p, let-7b-5p, and let-7f-5p, but not miR-130a-3p nor miR-130b-3p, was significantly higher in patients with ictal migraine compared with that of controls and patients with interictal migraine. +other 33314303 hsa-let-7b Cerebrovascular Disorders The abundance of let-7a-5p, let-7b-5p, and let-7f-5p, but not miR-130a-3p nor miR-130b-3p, was significantly higher in patients with ictal migraine compared with that of controls and patients with interictal migraine. +transcription factor target 33313955 hsa-mir-338 Osteoporosis Overall, the results suggested that miR3383p could suppress ageassociated osteoporosis by regulating PCSK5. +genetics_knock down_suppress 33313951 hsa-mir-375 Aortic Valve Insufficiency miR375 inhibition reversed the effects of circARRDC3 knockdown on GMCSF, eotaxin and MUC5AC expression levels, cell viability and cell apoptosis. +transcription factor target 33313948 hsa-mir-628 Alzheimer Disease miR6285p/TYROBP may inhibit progressive neurodegeneration in AD and could be used as novel biomarkers and candidate drug targets. +genetics_overexpression_promote 33313944 hsa-mir-381 Colorectal Neoplasms Functional assays revealed that miR381 inhibitor or RAP2A overexpression attenuated the suppressive effects of FLVCR1AS1 silencing on CRC cell viability, migration and invasion. Overall, the findings of the current study suggest that FLVCR1AS1 promotes CRC progression via the miR381/RAP2A pathway. +lncRNA target 33313942 hsa-mir-140 Glomerulonephritis, IGA The expression of DACH1 was negatively regulated by miR1403p in IgAN and miR1403p inhibition suppressed HMC growth and inhibited inflammatory cytokine release from HMCs cultured with pIgAIgAN. +lncRNA target 33313941 hsa-mir-221 Diabetic Cardiomyopathies GAS5 promoted cardiomyocyte autophagy in DCM to attenuate myocardial injury via the miR2213p/p27 axis. +lncRNA target 33313941 hsa-mir-2213 Diabetic Cardiomyopathies GAS5 promoted cardiomyocyte autophagy in DCM to attenuate myocardial injury via the miR2213p/p27 axis. +genetics_knock down_promote 33313940 hsa-mir-29b Ischemic Stroke The present study aimed to investigate the combined roles of lncRNA H19, microRNA (miR)29b, silent matingtype information regulation 2 homolog 1 (SIRT1) and peroxisome proliferatoractivated receptorg coactivator1alpha (PGC1alpha) following ischemic stroke. Collectively, the results of the present study demonstrated that lncRNA H19 knockdown ameliorated OGDinduced cell apoptosis and increases in inflammatory cytokine concentrations by regulating miR29b, SIRT1 and PGC1alpha expression levels, which suggested the potential role of lncRNA H19 in ischemic stroke. +circulation_biomarker_diagnosis_up 33313435 hsa-mir-21 Urinary Bladder Neoplasms The expression of miRNA-21 in cancerous tissues was significantly associated with blood concentration of Cd and Pb among BC patients. +circulation_biomarker_diagnosis_down 33313408 hsa-mir-491 Atherosclerosis 5p was downregulated in the atherosclerotic plaque tissues and plasma samples of the patients with atherosclerosis. +other 33313406 hsa-mir-550a Melanoma Prognostic analysis results showed that high expression levels of hsa-miR-550a-3p, CDK2 and POLR2A and low expression levels of hsa-miR5p in melanoma patients were associated with significantly reduced overall survival. +other 33313406 hsa-mir-150 Melanoma Prognostic analysis results showed that high expression levels of hsa-miR-550a-3p, CDK2 and POLR2A and low expression levels of hsa-miR5p in melanoma patients were associated with significantly reduced overall survival. +lncRNA target 33313263 hsa-mir-22 Intervertebral Disc Degeneration CONCLUSIONS: Our study indicated that FAM83H-AS1 relieved IVDD deterioration through sponging miR +target gene 33313253 hsa-mir-1287 Thyroid Neoplasms LMCD1 antisense RNA 1 (LMCD1-AS1) potentiates thyroid cancer cell growth and stemness via a positive feedback loop of LMCD1-AS1/miR-1287-5p/GLI2. +transcription factor target 33313245 hsa-mir-25 Intervertebral Disc Degeneration 3p could delay the progression of IDD by inhibiting IL-1beta-induced effects, and may be potential therapy for IDD in future. +other 33313241 hsa-mir-29b Intracranial Aneurysm This study aimed to explore the expression of miR-29b and cell division cycle 7-related protein kinase (CDC7) in patients with cerebral aneurysm (CA) and their effects on the proliferation and mobility of human umbilical artery smooth muscle cells (HUASMCs). +other 33313241 hsa-mir-29b Rupture METHODS: RNA levels of miR-29b and CDC7 were evaluated in the CA tissues and adjacent normal cerebral arteries from 18 patients undergoing surgery for CA rupture. +transcription factor target 33313241 hsa-mir-29 Celiac Disease CONCLUSIONS: miR3p inhibits cell proliferation and mobility via directly targeting CDC7, which could be a potential therapeutic target for vascular dysfunction related diseases, including atherosclerosis and CA. +transcription factor target 33313241 hsa-mir-29 Vascular Diseases CONCLUSIONS: miR3p inhibits cell proliferation and mobility via directly targeting CDC7, which could be a potential therapeutic target for vascular dysfunction related diseases, including atherosclerosis and CA. +other 33313241 hsa-mir-29b Celiac Disease RESULTS: The mRNA level of miR-29b was down-regulated (P<0.05), while the mRNA level of CDC7 was markedly elevated in CA patients (P<0.05). +transcription factor target 33313237 hsa-mir-99a Squamous Cell Carcinoma of Head and Neck 5p might participate in HPV16+ HNSCC progression through EMT related pathways and affect prognosis. +transcription factor target 33313237 hsa-mir-4746 Squamous Cell Carcinoma of Head and Neck 5p might participate in HPV16+ HNSCC progression through EMT related pathways and affect prognosis. +circulation_biomarker_diagnosis_down 33313203 hsa-mir-181b Sepsis For the in vitro experiments, rat brain microvascular endothelial cells (rBMECs) and rat brain astrocytes (rAstrocytes) were cultured with 10% serum harvested from sham, sepsis, and sepsis anta-miR-181b rats. +other 33313167 hsa-mir-137 Carcinoma, Hepatocellular Cell Counting Kit-8, Transwell, and wound healing assays, were used to evaluate the role of has-mir-137 in HCC cell proliferation and migration in vitro. +other 33312941 hsa-mir-662 Osteosarcoma Circ-03955 was significantly upregulated, and miR-3662 was downregulated in osteosarcoma. All these findings demonstrate that the presence of circ-03955 promotes EMT in osteosarcoma by acting as miR-3662 sponge-mediated MTDH expression. +other 33312757 hsa-mir-1224 Carcinoma, Hepatocellular Mechanistically, RNA immunoprecipitation and luciferase reporter assays were performed to confirm the interaction between circRASGRF2 and miR-1224 in HCC. +lncRNA target 33312756 hsa-mir-204 Thyroid Neoplasms Altogether, the central findings of our study suggest that MALAT1 contributes to TC progression through the upregulation of IGF2BP2 by binding to miR-204. +genetics_overexpression_suppress 33312754 hsa-mir-582 Uterine Cervical Neoplasms Consistently, miR3p inhibition phenocopied the biological effects of circEYA1 overexpression in cervical adenocarcinoma cells. +circulation_biomarker_prognosis_up 33312427 hsa-mir-21 Carcinoma, Hepatocellular CONCLUSION: The results from this work do not support clinically relevant prognostic value of circulating miR-21 in HCC patients in real-life settings. +target gene 33312390 hsa-mir-129 Uterine Cervical Neoplasms LINC01305 inhibits malignant progression of cervical cancer via miR-129-5p/Sox4 axis. +genetics_overexpression_suppress 33312387 hsa-mir-219 Carcinoma, Hepatocellular When NEK6 was overexpressed in HCC cells, this was sufficient to reverse the inhibitory impact of miR +transcription factor target 33312384 hsa-mir-137 Cognition Disorders CONCLUSION: Up-regulation of miR-137 can at least partially regulate PTN/PTPRZ pathway through the inhibition of PTN in a targeted manner, effectively inhibit cell apoptosis, and protect cognitive dysfunction caused by PRO. +other 33312362 hsa-mir-145 Esophageal Squamous Cell Carcinoma ROR and LMNB2 were up-regulated and miR-145 was down-regulated in EC tissues and cells. CONCLUSION: LMNB2 which is regulated by ROR and miR-145 was highly expressed in EC and promoted the proliferation and migration of EC in vitro and in vivo. +target gene 33312221 hsa-mir-214 Breast Neoplasms Berberine Inhibits the Expression of SCT through miR-214-3p Stimulation in Breast Cancer Cells. +lncRNA target 33312000 hsa-mir-129 Colorectal Neoplasms CONCLUSION: PITPNA-AS1 can expedite CRC cell proliferation and migration, and inhibit apoptosis through miR +genetics_overexpression_promote 33311650 hsa-mir-145 Melanoma 5p overexpression. +target gene 33311637 hsa-mir-200b Spinal Cord Injuries In vivo, miRNA200b-3p was critical for Wnt5a-induced NSC differentiation into neurons to promote motor functional and histological recovery after SCI by suppressing RhoA/Rock signaling. +other 33311569 hsa-mir-141 Lymphoma, Large B-Cell, Diffuse 3p/MAP4K4 might function as a promising therapeutic avenue for DLBCL treatment. +exosome 33311552 hsa-mir-375 Carcinoma, Merkel Cell miR-375 enrichment in MCC-derived extracellular vesicles suggests its intercellular signaling function. +lncRNA target 33311454 hsa-mir-125b-2 Squamous Cell Carcinoma of Head and Neck Taken together, these results suggested that the classical NF-kappaB pathway-activated AC007271.3 regulates EMT by miR-125b3p/Slug/E-cadherin axis to promote the development of OSCC, implicating it as a novel potential target for therapeutic intervention in this disease. +other 33311443 hsa-mir-455 Adenocarcinoma of Lung We conclude that Linc00426 accelerates LUAD progression by acting as a molecular sponge to regulate miR5p, and may be a potential novel tumor marker for LUAD. +circRNA target 33311442 hsa-mir-187 Carcinoma, Hepatocellular Taken together, these findings indicated that circular RNA hsa_circRNA_104348 might function as a competing endogenous RNA (ceRNA) to promotes HCC progression by targeting miR +transcription factor target 33311440 hsa-mir-99 Triple Negative Breast Neoplasms In conclusion, NUDT3-AS4 may play a proproliferative role in TNBC and be considered a relevant therapeutic target, and Comp34 presents promising activity as a single agent to inhibit TNBC through regulation of NUDT3-AS4 and miR-99s. +lncRNA target 33310761 hsa-mir-886 Squamous Cell Carcinoma of Head and Neck 3p suppression mediated by ARE took part in the proliferation and metastasis of OSCC. +circRNA target 33310596 hsa-mir-223 Pneumonia, Mycoplasma DISCUSSION: CircLRRK1 could suppress the proliferation, migration and invasion of trophoblast cells by regulating the PI3K/AKT signaling pathway via targeting miR3p, suggesting that circLRRK1 might be a potential biomarker for the treatment of PE. +lncRNA target 33310519 hsa-mir-21 Liver Cirrhosis In summary, we propose that miR-21, acting via the HIF-1alpha/VEGF signaling pathway, is involved in arsenite-induced hepatic fibrosis through mediating aberrant cross-talk of hepatocytes and HSCs. +genetics_GWAS 33310299 hsa-mir-146a Pre-Eclampsia DISCUSSION: Our data indicates that MiR-146a rs2910164 and INSR rs2059806 SNPs may not be significantly related with HDP in the Han population of Northeast China living in Heilongjiang Province. +other 33310279 hsa-mir-21 Nasopharyngeal Carcinoma The HR values of the subgroup analysis for miR-21 (HR = 2.344; 95 % CI: 1.927-2.850; P-value = 0.000), nasopharyngeal carcinoma (HR = 0.448; 95 % CI: 0.265-0.760; P = 0.003) and breast cancer (HR = 1.131; 95 % CI: 0.311-4.109; P = .85) were obtained. +other 33310279 hsa-mir-21 Breast Neoplasms The HR values of the subgroup analysis for miR-21 (HR = 2.344; 95 % CI: 1.927-2.850; P-value = 0.000), nasopharyngeal carcinoma (HR = 0.448; 95 % CI: 0.265-0.760; P = 0.003) and breast cancer (HR = 1.131; 95 % CI: 0.311-4.109; P = .85) were obtained. +exosome 33309839 hsa-mir-17 Hypoxia-Ischemia, Brain Taken together, the study suggested that astrocyte-derived exosomes could carry miR5p to protect neonatal rats from HIBD via inhibiting BNIP-2 expression. +genetics_overexpression_promote 33309838 hsa-mir-591 Breast Neoplasms Both miR-591 silencing and HK2 overexpression counteracted circ_0069094 inhibition-mediated influence on cell proliferation, apoptosis, and glycolysis in BC cells. In conclusion, these results indicated that circ_0069094 facilitated cell malignancy and glycolysis by upregulating HK2 through adsorbing miR-591, suggesting that circ_0069094 might be a prognostic biomarker and therapeutic target for BC. +genetics_GWAS 33309716 hsa-mir-34a Breast Neoplasms We aimed to investigate the potential use of modified exosomes derived from genetically modified dental pulp MSCs (DPSCs) as a carrier to deliver tumor suppressor miR-34a to repress proliferation of breast carcinoma cells. The anticancer effects of the miR-34a-loaded exosomes were evaluated on breast carcinoma cells through apoptosis, migration, and invasion assays. +genetics_knock down_promote 33309645 hsa-mir-211 Carcinoma, Hepatocellular Further studies showed that knockdown of NORAD or overexpression of miR +other 33309614 hsa-mir-22 Diabetic Retinopathy In addition, increased expression of miR-22 in RPEs correlated with diabetes and downregulation of circ-ITCH. +genetics_overexpression_promote 33308377 hsa-mir-144 Colonic Neoplasms In summary, miR-144 was highly expressed in CRC cell lines and CSCs, and the overexpression of miR-144 in CSCs significantly promoted the proliferation of CSCs, inhibited its apoptosis, and promoted its invasion ability. +circRNA target 33308284 hsa-mir-155 Stomach Neoplasms 5p-SMAD2 axis, and our study may offer novel biomarkers and therapeutic targets for GC. +genetics_knock down_suppress 33308276 hsa-mir-218 Carcinoma, Hepatocellular CONCLUSION: Circ_0003998 knockdown sensitized HCC cell to DOX by regulating miR +transcription factor target 33308227 hsa-mir-130b Acute Lung Injury CONCLUSION: In summary, miRNA-130b in BMSCs can enhance ENaC at least partially by targeting PTEN and activating PI3K/AKT pathway, which may provide a promising new direction for therapeutic strategy in ALI. +circulation_biomarker_diagnosis_ns 33308119 hsa-mir-96 Sepsis CONCLUSION: All the data reveal that serum decreased miR-96 may serve as a candidate noninvasive biomarker for NS diagnosis. +circulation_biomarker_diagnosis_down 33307899 hsa-mir-363 Renal Insufficiency, Chronic CONCLUSION: We identified a genome-wide serum miRNA expression profile in CKD patients, and serum miR +lncRNA target 33307898 hsa-mir-499 Acute Lung Injury 5p targets SIRT1 to aggravate LPS-induced ALI and it is a promising therapeutic target for the treatment of ALI. +genetics_overexpression_promote 33307856 hsa-mir-10b Alzheimer Disease METHODS: Rat AD models were established by injected with amyloid-beta(1-42) (Abeta(1-42)), which were mainly treated with lentivirus-miR-10b-5p inhibitor, or lentivirus-overexpressed homeobox D10 (HOXD10). +circRNA target 33307836 hsa-mir-145 Essential Hypertension Hsa_circ_0037897 may be a risk factor for essential hypertension via hsa-miR +genetics_knock down_suppress 33307448 hsa-mir-15b Necrosis To understand whether miR-15b-5p/TGFBR3 axis could involve in the process of necroptosis and inflammation, we further revealed that the high expression of miR-15b-5p and the knockdown of TGFBR3 can induce necroptosis. +genetics_knock down_suppress 33307448 hsa-mir-15b Inflammation To understand whether miR-15b-5p/TGFBR3 axis could involve in the process of necroptosis and inflammation, we further revealed that the high expression of miR-15b-5p and the knockdown of TGFBR3 can induce necroptosis. +genetics_knock down_promote 33307164 hsa-mir-142 Esophageal Squamous Cell Carcinoma 5p knockdown; however, ROS production, apoptosis and autophagy induced by PGD were almost eliminated when miR +circulation_biomarker_diagnosis_ns 33307107 hsa-mir-146a COVID-19 We showed that COVID-19 patients who did not respond to TCZ have lower serum levels of miR-146a-5p after the treatment (p = 0.007). Our data show that a blood-based biomarker, such as miR-146a-5p, can provide clues about the molecular link between inflammaging and COVID-19 clinical course, thus allowing to better understand the use of biologic drug armory against this worldwide health threat. +circulation_biomarker_diagnosis_up 33307020 hsa-mir-16 Pulmonary Fibrosis MicroRNA-16 mimic administration on day 14 after bleomycin challenge ameliorated pulmonary fibrosis and suppressed lung and serum expression of secreted protein acidic and rich in cysteine (SPARC). These findings support that microRNA-16 may be a promising therapeutic target for IPF. +lncRNA target 33306406 hsa-mir-34a Triple Negative Breast Neoplasms We demonstrate that miR-34a/NS can regulate downstream miR-34a targets following irradiation to reduce TNBC cell viability, proliferation, and migration. +other 33305905 hsa-mir-1 Adenocarcinoma of Lung Therefore, miR-1 could be a clinically useful marker to predict therapeutic efficacy of immunotherapy in lung adenocarcinoma patients with EGFR-TKI resistance. +genetics_knock down_promote 33305725 hsa-mir-206 Osteoarthritis Taken together, our results indicated that RMRP knockdown could promote proliferation and inhibit apoptosis in OA chondrocytes via the miR-206/CDK9 axis. +virus_miRNA 33305599 ebv-mir-BART6 Nasopharyngeal Carcinoma EBV-miR-BART6-5p may target Dicer1 to facilitate proliferation and metastasis of NPC cells and suppress apoptosis, thus being a new target for NPC therapy. +lncRNA target 33305412 hsa-mir-431 Osteoarthritis CONCLUSIONS: Our findings demonstrate that the circADAMTS6/miR5p axis comprises a new target for OA. +other 33305412 hsa-mir-431 Lissencephaly The present study aimed to explore the CircADAMTS6/miR5p axis with respect to regulating interleukin-1beta (IL-1beta) induced chondrocyte apoptosis. +other 33305404 hsa-mir-32 Endomyocardial Fibrosis 5p-KLF3 pathway is involved in the regulation of differential fat deposition of IMF and SCF tissues. +other 33305374 hsa-mir-26a Hypertension MiR-26a has an antagonistic effect on hypertensive vascular remodelling and can be a strategy for treating hypertensive vascular remodelling. +other 33305319 hsa-mir-7 late onset Parkinson's disease We evaluated HiTmIR using miR-34a-5p, for which TNF- and TGFB-signaling, and Parkinson's Disease (PD)-related categories were identified and repeated the pipeline for miR5p. +other 33305319 hsa-mir-34a late onset Parkinson's disease We evaluated HiTmIR using miR-34a-5p, for which TNF- and TGFB-signaling, and Parkinson's Disease (PD)-related categories were identified and repeated the pipeline for miR5p. +other 33305319 hsa-mir-34a Parkinson Disease We evaluated HiTmIR using miR-34a-5p, for which TNF- and TGFB-signaling, and Parkinson's Disease (PD)-related categories were identified and repeated the pipeline for miR5p. +other 33305319 hsa-mir-7 Parkinson Disease We evaluated HiTmIR using miR-34a-5p, for which TNF- and TGFB-signaling, and Parkinson's Disease (PD)-related categories were identified and repeated the pipeline for miR5p. +transcription factor target 33305155 hsa-mir-125b Liver Diseases Conclusion: miR-125b-5p has an important role in regulating hepatocyte proliferation in the termination phase of liver regeneration and may serve as a potential therapeutic target in various liver diseases that often exhibit deregulated hepatocyte proliferation. +epigenetics 33304897 hsa-mir-20a Carcinoma, Non-Small-Cell Lung CONCLUSION: Taken together, our findings were suggestive of the inhibitory effect of miR-320a on radioresistance of NSCLC through HIF1alpha-suppression mediated methylation of PTEN. +other 33303811 hsa-let-7f Carcinoma, Hepatocellular Six miRNAs (let-7f-5p, miR-10b-5p, 143-3p, 191-5p, 21a-5p, and 26a-5p) were upregulated, similarly to human HCC cases. +other 33303006 hsa-mir-218 Osteoarthritis MiR-218 expression was quantified in healthy and osteoarthritic cartilage of patients. Moreover, no correlation between miR-218 expression and a pathologic phenotype in the cartilage of osteoarthritis (OA) patients was found. +lncRNA target 33303006 hsa-mir-218 Hypertrophy CONCLUSIONS: Although miR-218 was shown to target pro-hypertrophic markers MEF2C, COL10A1, and RUNX2 in human MSC during chondrogenic differentiation, overall, it could not significantly reduce the hypertrophic phenotype or boost chondrogenesis. +lncRNA target 33302997 hsa-mir-216b Carcinoma, Ovarian Epithelial AIM: This study aimed to explore whether the dysregulation of lnc-small nucleolar RNA host gene 1 (SNHG1) and miR-216b-5p correlated with chemoresistance and indicated poor prognosis of serous epithelial ovarian cancer (EOC). Lnc-SNHG1 functioned as a ceRNA with miR-216b-5p, which was critical in modulating the paclitaxel sensitivity of ovarian cancer cells. +genetics_knock down_promote 33302819 hsa-mir-195 Small Cell Lung Carcinoma Further loss of function and enhancement experiments revealed that miRNA-195 overexpression could significantly inhibit SCLC cell proliferation and promote cell apoptosis by upregulation of Bax and down-regulation of bcl-2; Luciferase reporter assay demonstrated that miRNA-195 could bind to Rap2C mRNA and inhibit its expression, Rap2C overexpression also related to the poorer prognosis of lung patients. +other 33302703 hsa-mir-27a Diabetic Nephropathies RESULTS: The expression of miR-193a-3p and miR-320c was elevated and miR-27a-3p was decreased in diabetic nephropathy patients compared to patients with type 2 diabetes and healthy controls. +other 33302703 hsa-mir-320c Diabetic Nephropathies RESULTS: The expression of miR-193a-3p and miR-320c was elevated and miR-27a-3p was decreased in diabetic nephropathy patients compared to patients with type 2 diabetes and healthy controls. +other 33302703 hsa-mir-193a Diabetic Nephropathies CONCLUSION: In conclusion, miR-193a-3p is involved in diabetic nephropathy pathogenesis and may serve as a potentially novel diagnostic biomarker for diabetic nephropathy. +other 33302540 hsa-mir-216a Carcinoma, Non-Small-Cell Lung Our findings illustrate a role of DANCR in NSCLC migration and stemness, and suggest a novel DANCR/miR-216a signaling axis in the Wnt/beta-catenin pathway. +circulation_biomarker_diagnosis_ns 33302347 hsa-mir-4632 Intervertebral Disc Degeneration 5p signature from serum may serve as a noninvasive diagnostic biomarker for LHD manifestation of IVD degeneration. +circulation_biomarker_diagnosis_ns 33302347 hsa-mir-6749 Intervertebral Disc Degeneration 5p signature from serum may serve as a noninvasive diagnostic biomarker for LHD manifestation of IVD degeneration. +circulation_biomarker_diagnosis_ns 33302347 hsa-mir-766 Intervertebral Disc Degeneration 5p signature from serum may serve as a noninvasive diagnostic biomarker for LHD manifestation of IVD degeneration. +circRNA target 33301895 hsa-mir-671 Breast Neoplasms Furthermore, circSLC8A1 could sponge miR-671 to suppress breast tumor growth via PTEN/PI3k/Akt signaling in vivo. In summary, circSLC8A1/miR-671 regulates breast cancer progression through PTEN/PI3k/Akt signaling, which may provide efficient therapeutic target for this devastating cancer. +other 33301881 hsa-mir-23a Intestinal Diseases In conclusion, our study revealed that the Nrf2/miR-23a-27a2/Bach1/HO-1 regulatory axis promotes the damage repair of intestinal mucosa during the development of inflammatory bowel diseases. +other 33301856 hsa-mir-23 Lung Neoplasms Also, among miRNAs, let-7, miR-23, miR-34, miR-125, miR-146 were downregulated and miR-20, miR-424 were upregulated in HPV-positve tissues compared to HPV-negative tissues. +other 33301856 hsa-let-7 Lung Neoplasms Also, among miRNAs, let-7, miR-23, miR-34, miR-125, miR-146 were downregulated and miR-20, miR-424 were upregulated in HPV-positve tissues compared to HPV-negative tissues. +other 33301856 hsa-mir-4 Lung Neoplasms Also, among miRNAs, let-7, miR-23, miR-34, miR-125, miR-146 were downregulated and miR-20, miR-424 were upregulated in HPV-positve tissues compared to HPV-negative tissues. +other 33301856 hsa-mir-146 Lung Neoplasms Also, among miRNAs, let-7, miR-23, miR-34, miR-125, miR-146 were downregulated and miR-20, miR-424 were upregulated in HPV-positve tissues compared to HPV-negative tissues. +other 33301856 hsa-mir-125 Lung Neoplasms Also, among miRNAs, let-7, miR-23, miR-34, miR-125, miR-146 were downregulated and miR-20, miR-424 were upregulated in HPV-positve tissues compared to HPV-negative tissues. +other 33301856 hsa-mir-424 Lung Neoplasms Also, among miRNAs, let-7, miR-23, miR-34, miR-125, miR-146 were downregulated and miR-20, miR-424 were upregulated in HPV-positve tissues compared to HPV-negative tissues. +other 33301856 hsa-mir-20 Lung Neoplasms Also, among miRNAs, let-7, miR-23, miR-34, miR-125, miR-146 were downregulated and miR-20, miR-424 were upregulated in HPV-positve tissues compared to HPV-negative tissues. +lncRNA target 33301605 hsa-mir-505 Cholangiocarcinoma Biofunctional experiments revealed that a miR-505 inhibitor almost completely removed the inhibitory effect of si-DLGAP1-AS2 on CCA cell malignant progression, whereas the malignant phenotype of cells cotransfected with si-DLGAP1-AS2 and si-GALNT10 was significantly reduced as compared with the control. +lncRNA target 33301423 hsa-mir-223 Non-alcoholic Fatty Liver Disease enriched EV transfer from neutrophils to hepatocytes may serve as a potential therapeutic target for NASH. +lncRNA target 33300439 hsa-mir-21 Liver Diseases In this study, we investigated the role of miR-21 in modulating the gut microbiota during cholestasis and its effects in liver dysfunction. Altogether, our results demonstrate that miR-21 promotes liver dysfunction through direct modulation of the gut microbiota and highlight the potential therapeutic effects of Lactobacillus supplementation in gut and liver homeostasis. +other 33300377 hsa-mir-185 Carcinoma, Non-Small-Cell Lung 5p/Six1 axis might serve as a novel biomarker for the diagnosis and treatment of LSCC. +lncRNA target 33300085 hsa-mir-139 Carcinoma, Non-Small-Cell Lung Furthermore, HOXB2 was identified to be a target of miR1395p, and miR1395p was revealed to sensitize NSCLC cells to DDP via the targeting of HOXB2. +genetics_overexpression_suppress 33300079 hsa-mir-6324 Sarcoma, Ewing In addition, miR-6324 mimic partially reversed the effects of Dancr overexpression on Tm-induced apoptosis, ERS and autophagy. In conclusion, lncRNA Dancr overexpression protected cardiomyocytes against ERS injury via sponging miR-6324, thus inhibiting apoptosis, enhancing autophagy and restoring ER homeostasis. +other 33300079 hsa-mir-6324 Myocardial Infarction microRNA (miR)-6324 was upregulated in MI model rats and was predicted to bind to Dancr. +genetics_overexpression_promote 33300072 hsa-mir-654 Carcinoma, Non-Small-Cell Lung Furthermore, the present study revealed that overexpression of miR6543p could suppress the viability and induce the apoptosis of cells by targeting RASAL2 in NSCLC. +circulation_biomarker_diagnosis_ns 33300070 hsa-let-7f Pneumonia The reverse transcriptionquantitative PCR (RTqPCR) and western blotting results demonstrated that let7f5p expression levels were significantly decreased, whereas MAPK6 expression levels were significantly increased in the peripheral venous blood of patients with pneumonia and in LPSinduced A549 and WI38 cells compared with healthy volunteers and control cells, respectively. +lncRNA target 33300069 hsa-mir-130b Cholelithiasis In vivo experiments also confirmed the role of the miR130bSp1MUC5AC signaling pathway in the formation of biliary stones and indicated that this pathway may provide targeted therapeutic strategies for the treatment of intrahepatic bile duct stones. +lncRNA target 33300069 hsa-mir-130b Cholestasis, Intrahepatic In vivo experiments also confirmed the role of the miR130bSp1MUC5AC signaling pathway in the formation of biliary stones and indicated that this pathway may provide targeted therapeutic strategies for the treatment of intrahepatic bile duct stones. +lncRNA target 33300066 hsa-mir-193b Leukemia, Myeloid, Acute SNHG14 silencing decreased the viability and promoted apoptosis of AML cells by modulating the miR193b3p/MCL1 axis. +genetics_knock down_suppress 33300061 hsa-mir-373 Osteoarthritis Furthermore, the luciferase activity assay suggested that SNHG16 negatively regulated miR3733p in OA. In conclusion, lncRNA SNHG16 knockdown significantly limited the progression of OA by sponging miR3733p in vitro, which suggested that SNHG16 may serve as a potential therapeutic target for OA. +other 33300060 hsa-mir-137 Colorectal Neoplasms In conclusion, the present study indicated that ZFPM2AS1 may serve as an oncogene in CRC by regulating the miR137/TRIM24 axis. +transcription factor target 33300054 hsa-mir-576 Colorectal Neoplasms In conclusion, the findings from the present study suggested that inhibition of miR5765p may suppress SW480 cell metastasis and EMT by targeting Wnt5a and regulating the Wnt5amediated Wnt/betacatenin signaling pathway, providing a potential therapeutic target for the treatment of CRC. +genetics_overexpression_suppress 33300052 hsa-mir-495 Colorectal Neoplasms Furthermore, functional studies indicated that miR4953p overexpression inhibited CRC cell proliferation, migration and invasion, while accelerating cell apoptosis. +transcription factor target 33300051 hsa-mir-34c Uterine Cervical Neoplasms It also demonstrated that miR34c5p targeted Notch1 and suppressed CC progression. +epigenetics 33300049 hsa-mir-34b Endometrial Neoplasms Among 821 candidate miRNAs, miR34b was identified as an upregulated miRNA after demethylation treatment in all four endometrial cancer cell lines (HEC108, SNGII, Ishikawa and HHUA) examined. These data suggest that miR34b enhances paclitaxel sensitivity in endometrial cancer cells, and that miR34b and MET are key targets for treatment of endometrial cancer. +transcription factor target 33299881 hsa-mir-346 Bone Diseases These results together demonstrated that miR5p served a key role in BMSC osteogenic differentiation of through targeting TMEM9, which may provide a novel target for clinical treatments of bone injury. +genetics_knock down_suppress 33299853 hsa-mir-3125 Colonic Neoplasms Rescue assays revealed that miR-3125 inhibitor or TRIM22 overexpression significantly reversed the repressive role of LINC01207 knockdown in colon cancer cell proliferation and invasion. +transcription factor target 33299464 hsa-mir-195 Diabetic Nephropathies CONCLUSION: Narenmandula may modulate doxorubicin-induced nephropathy via targeting miR +transcription factor target 33299464 hsa-mir-181c Diabetic Nephropathies CONCLUSION: Narenmandula may modulate doxorubicin-induced nephropathy via targeting miR +transcription factor target 33299464 hsa-mir-497 Diabetic Nephropathies CONCLUSION: Narenmandula may modulate doxorubicin-induced nephropathy via targeting miR +transcription factor target 33299464 hsa-mir-30 Diabetic Nephropathies CONCLUSION: Narenmandula may modulate doxorubicin-induced nephropathy via targeting miR +transcription factor target 33299464 hsa-mir-34a Diabetic Nephropathies CONCLUSION: Narenmandula may modulate doxorubicin-induced nephropathy via targeting miR +transcription factor target 33299464 hsa-mir-181a Diabetic Nephropathies CONCLUSION: Narenmandula may modulate doxorubicin-induced nephropathy via targeting miR +other 33299353 hsa-mir-381 Breast Neoplasms 3p for binding to FAM234B, thereby upregulating the expression of FAM234B in luminal BC. +other 33299353 hsa-mir-1271 Breast Neoplasms 3p for binding to FAM234B, thereby upregulating the expression of FAM234B in luminal BC. +target gene 33299350 hsa-mir-361 Lymphoma MicroRNA-361-3p Inhibit the Progression of Lymphoma by the Wnt/β-Catenin Signaling Pathway. +other 33298994 hsa-let-7c Muscular Dystrophy, Duchenne In summary, we show that PMO-based let-7c SBO has potential applicability for upregulating utrophin expression as a therapeutic approach for DMD. +lncRNA target 33298873 hsa-mir-212 Pancreatic Carcinoma Taken together, our findings suggest that PTTG3P promotes PDAC progression through PTTG3P/miR-132/212-3p/FoxM1 feedforward circuitry and it may serve as a promising diagnostic marker or target for treatment in PDAC patients. +lncRNA target 33298873 hsa-mir-132 Pancreatic Carcinoma Taken together, our findings suggest that PTTG3P promotes PDAC progression through PTTG3P/miR-132/212-3p/FoxM1 feedforward circuitry and it may serve as a promising diagnostic marker or target for treatment in PDAC patients. +circRNA target 33298736 hsa-mir-370 Atherosclerosis Our findings demonstrated that circ-BANP regulated ox-LDL-induced cell injury in HUVECs at least in part through targeting the miR-370/TXNIP axis, illuminating circ-BANP as a potential target for AS detection and treatment. +transcription factor target 33298561 hsa-mir-146a Dmd-Associated Dilated Cardiomyopathy Increased CDCex-derived miR-146a-5p expression was associated with the reduction in myocardial fibrosis via suppression of proinflammatory cytokines and transcripts. +circulation_biomarker_diagnosis_up 33298110 hsa-mir-15b Norrie disease RESULTS: CDKN2B-AS1 and WNT2B were upregulated while miR-15b-5p was downregulated in serum of DN patients and HG-treated HMCs. CONCLUSION: CDKN2B-AS1 regulated HG-induced HMC viability, cell cycle progression, ECM accumulation, and inflammation response via regulating the miR-15b-5p/WNT2B axis, provided a new mechanism for understanding the development of DN. +virus_miRNA 33298092 hcmv-mir-US4 Viremia the serum levels of hcmv-miR-US25-2-3p, hcmv-miR-US4-5p, hcmv-miR-US25-2-5p, hcmv-miR-US25-1-3p, hcmv-miR-US25-1, hcmv-miR-UL36, hcmv-miR-UL148D, hcmv-miR-US29-3p were markedly elevated (fold change > 2, P < 0.01). +virus_miRNA 33298092 hcmv-mir-US25-2 Viremia the serum levels of hcmv-miR-US25-2-3p, hcmv-miR-US4-5p, hcmv-miR-US25-2-5p, hcmv-miR-US25-1-3p, hcmv-miR-US25-1, hcmv-miR-UL36, hcmv-miR-UL148D, hcmv-miR-US29-3p were markedly elevated (fold change > 2, P < 0.01). +virus_miRNA 33298092 hcmv-mir-UL148D Viremia the serum levels of hcmv-miR-US25-2-3p, hcmv-miR-US4-5p, hcmv-miR-US25-2-5p, hcmv-miR-US25-1-3p, hcmv-miR-US25-1, hcmv-miR-UL36, hcmv-miR-UL148D, hcmv-miR-US29-3p were markedly elevated (fold change > 2, P < 0.01). +virus_miRNA 33298092 hcmv-mir-US29 Viremia the serum levels of hcmv-miR-US25-2-3p, hcmv-miR-US4-5p, hcmv-miR-US25-2-5p, hcmv-miR-US25-1-3p, hcmv-miR-US25-1, hcmv-miR-UL36, hcmv-miR-UL148D, hcmv-miR-US29-3p were markedly elevated (fold change > 2, P < 0.01). +virus_miRNA 33298092 hcmv-mir-US36 Viremia the serum levels of hcmv-miR-US25-2-3p, hcmv-miR-US4-5p, hcmv-miR-US25-2-5p, hcmv-miR-US25-1-3p, hcmv-miR-US25-1, hcmv-miR-UL36, hcmv-miR-UL148D, hcmv-miR-US29-3p were markedly elevated (fold change > 2, P < 0.01). +virus_miRNA 33298092 hcmv-mir-US25-1 Viremia the serum levels of hcmv-miR-US25-2-3p, hcmv-miR-US4-5p, hcmv-miR-US25-2-5p, hcmv-miR-US25-1-3p, hcmv-miR-US25-1, hcmv-miR-UL36, hcmv-miR-UL148D, hcmv-miR-US29-3p were markedly elevated (fold change > 2, P < 0.01). +other 33298086 hsa-mir-26a Adenocarcinoma of Lung METHODS: The expression of ATF2, NEAT1 and miR-26a-5p in LUAD tissues and cell lines was detected by qRT-PCR and western blotting. CONCLUSION: ATF2 and NEAT1 form a positive feedback loop mediated by miR-26a-5p and coordinately contribute to LUAD progression. +genetics_overexpression_suppress 33298078 hsa-mir-196 Pancreatic Carcinoma Importantly, nuclear factor I X (NFIX), overexpressed in PC cell lines, was validated to be positively modulated by MAFG-AS1 through absorbing miR-3196. +lncRNA target 33298070 hsa-mir-532 Glioma Furthermore, it was found that FBXL19 targeted by miR +other 33298061 hsa-mir-4500 Breast Neoplasms Circular RNA circPLK1 promotes breast cancer cell proliferation, migration and invasion by regulating miR-4500/IGF1 axis. +genetics_GWAS 33297930 hsa-mir-506 Breast Neoplasms 3p is a potential tumor suppressor miRNA in BC that has a potential role in regulating B7-H4 SNP rs10754339 (A/G). +lncRNA target 33297929 hsa-mir-122 Colonic Neoplasms Being confirmed as tumor suppressor microRNA in liver carcinogenesis, we aimed to study the expression of microRNA-122 in colon cancer cell lines and the role of microRNA-122 in cell proliferation, invasion and migration of colon cancer cells. +other 33297927 hsa-mir-146a Coronary Artery Disease CONCLUSION Our findings indicated that Hsa-miR-146a-5p rs2910164 GG genotype and G allele are associated with increased susceptibility to Coronary Artery Disease. +transcription factor target 33297397 hsa-mir-888 Squamous Cell Carcinoma of Head and Neck We transfected LSCC cells with miR5p inhibitor and exposed the cells to AdoMet for 48 and 72 h. +genetics_knock down_promote 33296783 hsa-mir-214 Osteoarthritis METHODS: We used interleukin-1beta (IL-1beta) to treat to establish an OA model primary on chondrocytes in vitro, and gain- and loss of function assays of SNHG7 and miR +lncRNA target 33296782 hsa-mir-155 Sepsis These findings reveal that the miR-155 inhibitor alleviates inflammation and intestinal barrier dysfunction by inactivating NF-kappaB signaling during sepsis. +lncRNA target 33296782 hsa-mir-155 Inflammation These findings reveal that the miR-155 inhibitor alleviates inflammation and intestinal barrier dysfunction by inactivating NF-kappaB signaling during sepsis. +lncRNA target 33296782 hsa-mir-155 Intestinal Diseases These findings reveal that the miR-155 inhibitor alleviates inflammation and intestinal barrier dysfunction by inactivating NF-kappaB signaling during sepsis. +lncRNA target 33296289 hsa-mir-486a Kidney Diseases sC5b-9 induces pyroptosis in podocytes through modulating the Kcnq1ot1/miR-486a-3p/NLRP3 regulatory axis, and these uncovered key molecules might facilitate podocyte-targeted treatment for renal inflammatory diseases. +lncRNA target 33296140 hsa-mir-374a Myocardial Reperfusion Injury The results showed that TTTY15 suppresses autophagy and myocardial I/R injury by targeting miR-374a-5p. +other 33296098 hsa-mir-17 Colorectal Neoplasms CONCLUSION BRAF/MIR17 ratio could have prognostic utility in patients with CRC. +lncRNA target 33295056 hsa-mir-126 Stomach Neoplasms 5p/BRCC3 axis was involved in GC progression via the regulation of PI3K/Akt/mTOR pathway, which might provide a potential therapeutic strategy for GC. +other 33294994 hsa-mir-4318 Hirschsprung Disease CONCLUSIONS In summary, we report that miR-4318 rs8096901 was associated with HSCR, especially in SHSCR patients. +exosome 33294586 hsa-mir-21 Breast Neoplasms Mesenchymal Stem Cell-Secreted Exosome Promotes Chemoresistance in Breast Cancer via Enhancing miR-21-5p-Mediated S100A6 Expression. +lncRNA target 33294296 hsa-mir-10a Osteoarthritis Twist Family BHLH Transcription Factor 1 (TWIST1) and mitogen-activated protein kinase kinase kinase 7 (MAP3K7) were identified as an upstream regulator and direct target of miR-10a in OA-FLSs, respectively. +lncRNA target 33294296 hsa-mir-10a Synovitis Twist Family BHLH Transcription Factor 1 (TWIST1) and mitogen-activated protein kinase kinase kinase 7 (MAP3K7) were identified as an upstream regulator and direct target of miR-10a in OA-FLSs, respectively. +exosome 33294295 hsa-mir-140 Intervertebral disc disease Clinical evidence showed that exosomal miR5p expression of the nucleus pulposus is negatively correlated with angiogenesis in IDD. +exosome 33294294 hsa-mir-1 Osteoarthritis, Knee SMSC-EV-encapsulated miR-31 ameliorates knee OA via the KDM2A/E2F1/PTTG1 axis. +transcription factor target 33294293 hsa-mir-135a Spinal Cord Injuries This study aimed to investigate the mechanisms of miR-135a-5p in regulating the functional recovery of SCI by impacting its target genes and downstream signaling. +genetics_GWAS 33294082 hsa-mir-155 Carcinoma, Non-Small-Cell Lung CONCLUSION: Our finding suggests that miR-146a rs2910164 and miR-155 rs767649 polymorphisms may be considered as genetic risk factors for the susceptibility to NSCLC in the Iranian population. +genetics_GWAS 33294082 hsa-mir-146a Carcinoma, Non-Small-Cell Lung CONCLUSION: Our finding suggests that miR-146a rs2910164 and miR-155 rs767649 polymorphisms may be considered as genetic risk factors for the susceptibility to NSCLC in the Iranian population. +other 33294032 hsa-mir-613 Atrial Fibrillation Our study suggests that HOTAIR, functioning as a ceRNA by sponging miR-613, is an important contributor to Cx43 remolding in AF. +lncRNA target 33293866 hsa-mir-326 Adenocarcinoma of Lung CONCLUSION: TMPO-AS1 can modulate LUAD cell proliferation through E2F1/miR-326/SOX12 pathway. +target gene 33293831 hsa-mir-129 Osteosarcoma TRPS1 and YAP1 Regulate Cell Proliferation and Drug Resistance of Osteosarcoma via Competitively Binding to the Target of circTADA2A - miR-129-5p. +lncRNA target 33293695 hsa-mir-155 Neurofibroma, Plexiform MicroRNA-155 contributes to plexiform neurofibroma growth downstream of MEK. These results suggest that miR-155 plays a functional role in PNF growth and/or SC proliferation, and that targeting neurofibroma miRs is feasible, and might provide novel therapeutic opportunities. +lncRNA target 33293585 hsa-mir-100 Carcinoma, Hepatocellular Comparing miRNA profiling of patient-derived tumorsphere (TS) and adherent (2D) hepatocellular carcinoma cells, miR-100 and miR-125b are identified to have association with stemness. In conclusion, miR-100 and miR-125b have tumor suppressor role in hepatocellular carcinoma through inhibiting IGF2 expression and activation of the AKT/mTOR pathway. +lncRNA target 33293585 hsa-mir-125b Carcinoma, Hepatocellular Comparing miRNA profiling of patient-derived tumorsphere (TS) and adherent (2D) hepatocellular carcinoma cells, miR-100 and miR-125b are identified to have association with stemness. In conclusion, miR-100 and miR-125b have tumor suppressor role in hepatocellular carcinoma through inhibiting IGF2 expression and activation of the AKT/mTOR pathway. +other 33293557 hsa-mir-4769 Common Variable Immunodeficiency 2@En 3p, hsa-miR-1972) differently modulated in CVID patients by Ig infusion. +other 33293557 hsa-mir-1972 Common Variable Immunodeficiency 2@En 3p, hsa-miR-1972) differently modulated in CVID patients by Ig infusion. +other 33293557 hsa-mir-1228 Common Variable Immunodeficiency 2@En 3p, hsa-miR-1972) differently modulated in CVID patients by Ig infusion. +other 33293557 hsa-mir-6742 Common Variable Immunodeficiency 2@En 3p, hsa-miR-1972) differently modulated in CVID patients by Ig infusion. +lncRNA target 33293505 hsa-mir-452 Atherosclerosis Taken together, these findings suggest that kcnq1ot1 promotes macrophage lipid accumulation and accelerates the development of atherosclerosis through the miR +other 33293495 hsa-mir-1283 Myocardial Infarction RESULTS: GADD45A and miR-1283 were upregulated or downregulated in myocardial infarction, respectively. +circulation_biomarker_diagnosis_ns 33293478 hsa-mir-18a Diabetes Mellitus Quantitative real-time PCR indicated that serum miR-18a levels were lower in type 2 diabetes mellitus patients than in healthy controls, suggesting that miR-18a may influence blood glucose levels. This makes miR-18a a potentially useful target for the treatment of diabetes mellitus in the future. +circulation_biomarker_diagnosis_ns 33293478 hsa-mir-18a Diabetes Mellitus, Type 2 Quantitative real-time PCR indicated that serum miR-18a levels were lower in type 2 diabetes mellitus patients than in healthy controls, suggesting that miR-18a may influence blood glucose levels. +transcription factor target 33293476 hsa-mir-139 Diabetes Mellitus Therefore, miR5p might be an important therapeutic target in the treatment of diabetic vasculopathy in the future. +transcription factor target 33292473 hsa-mir-351 Seizures 5p in hippocampal astrocytes via activating astrocytic NMDA receptor, and locally reduction of Lrp4 in hippocampus increased the threshold of seizures. +transcription factor target 33292274 hsa-mir-135a Medulloblastoma After inhibition of miR-135b or miR135a which were the most significantly increased in BTSCs, cell viability, self-renewal and stem cell marker expression decreased remarkably. CONCLUSION: Our results indicated that inhibition of miR-135b or miR-135a leads to suppress stemness of BTSC through modulation of AMOTL2. +transcription factor target 33292274 hsa-mir-135b Medulloblastoma After inhibition of miR-135b or miR135a which were the most significantly increased in BTSCs, cell viability, self-renewal and stem cell marker expression decreased remarkably. CONCLUSION: Our results indicated that inhibition of miR-135b or miR-135a leads to suppress stemness of BTSC through modulation of AMOTL2. +genetics_knock down_promote 33292255 hsa-mir-942 Ovarian Neoplasms CONCLUSION: Knockdown of circ_0015756 suppressed OC progression via regulating miR5p/CUL4B axis, suggesting that circ_0015756 might be a potential therapeutic target for ovarian cancer. +other 33292252 hsa-mir-27b Stomach Neoplasms CONCLUSION: NEAT1 depletion enhanced radio-sensitivity of GC by negatively regulating miR-27b-3p in vitro and in vivo. +lncRNA target 33292246 hsa-mir-23a Colorectal Neoplasms SNHG17 promoted CRA cell proliferation and migration by sponging miR-23a-3p to upregulate CXCL12. CONCLUSION: SNHG17 promotes the proliferation and migration of CRA cells by inhibiting miR-23a-3p to modulate CXCL12-mediated angiogenesis. +genetics_knock down_promote 33292236 hsa-mir-520a Carcinoma, Non-Small-Cell Lung Moreover, CDK4 was a target of miR-520a-5p, and rescue experiments showed that CDK4 knockdown reversed the aggressive effects of miR-520a-5p inhibition on NSCLC progression. CONCLUSIONS: Exosome-transmitted hsa_circ_0014235 promoted NSCLC malignant development by mediating the miR-520a-5p/CDK4 regulatory axis. +lncRNA target 33292234 hsa-mir-1305 Esophageal Squamous Cell Carcinoma Moreover, miR-1305 was observed to exert a tumor-suppressive effect in ESCC cells by directly targeting and repressing TXNRD1. +other 33292230 hsa-mir-206 Carcinoma, Ovarian Epithelial CONCLUSION: miR-206 was highly expressed in primary platinum-resistant EOCs and functionally promoted platinum resistance in part by downregulating Cx43 expression, thereby providing a useful biomarker for prognostic and platinum-resistance prediction. +other 33292220 hsa-mir-486 Polycystic Ovary Syndrome RESULTS: NEAT1 is upregulated and miR5p is downregulated in the posterior capsular tissues of PCO patients and TGF-beta2-induced LECs. +target gene 33292218 hsa-mir-628 Uterine Cervical Neoplasms DARS-AS1 accelerates the proliferation of cervical cancer cells via miR-628-5p/JAG1 axis to activate Notch pathway. +lncRNA target 33292210 hsa-mir-365 Precancerous Conditions mediated TLR4 inhibition reduces IRF3 phosphorylation and YAP-mediated CDX2 transcription to impede progression of gastric precancerous lesions. +circulation_biomarker_diagnosis_up 33292168 hsa-mir-296 Nasopharyngeal Carcinoma Finally, TGF-beta expression plasmids were transfected into NPC cells to verify the role of TGF-beta in the miR +other 33292148 hsa-mir-29a Acquired Immunodeficiency Syndrome The aim of the current study is to evaluate the expression of mir-221, mir-29a, mir-155, and mir-146a in HIV-1 infected patients. +other 33292148 hsa-mir-221 Acquired Immunodeficiency Syndrome The aim of the current study is to evaluate the expression of mir-221, mir-29a, mir-155, and mir-146a in HIV-1 infected patients. +other 33292148 hsa-mir-155 Acquired Immunodeficiency Syndrome The aim of the current study is to evaluate the expression of mir-221, mir-29a, mir-155, and mir-146a in HIV-1 infected patients. +other 33292148 hsa-mir-146a Acquired Immunodeficiency Syndrome The aim of the current study is to evaluate the expression of mir-221, mir-29a, mir-155, and mir-146a in HIV-1 infected patients. +genetics_knock down_suppress 33291871 hsa-mir-145 Scholte syndrome The opposite pattern was observed when miR-145 was knocked down in SCHL cells, with these effects being attenuated by subsequent hnf4alpha knockdown. Moreover, increasing endogenous Hnf4alpha by the knockdown of miR-145 increased the expression of LC-PUFA biosynthesis genes and enhanced the synthesis of LC-PUFA in both SCHL cells and rabbitfish in vivo. +other 33291534 hsa-mir-15a Asthma Conclusions: These results provide evidence for the role of miR-15a in the fetal origin of asthma. +transcription factor target 33291448 hsa-mir-155 psoriasis 1 Therefore, miR-155 represents as a potential target for treating psoriatic skin lesions. +genetics_GWAS 33291316 hsa-mir-506 Carcinoma, Non-Small-Cell Lung MicroRNA-506 (miR-506) has been identified as a tumor suppressor in many cancers, including lung cancer; however, the role of miR-506 in lung cancer chemoresistance has not yet been addressed. Our results advanced our understanding of the molecular mechanisms underlying EGFR-TKI resistance and indicated that the miR-506/SHH axis might represent a novel therapeutic target for future EGFR mutated lung cancer treatment. +genetics_GWAS 33291080 hsa-mir-196a Diabetes Complications In a multivariate analysis, independent risk factors of PTLF were genetic variation of donor GRP78 rs430397 (OR = 8.99, p = 0.003), GSTP1 rs1695 (OR = 0.13, p = 0.021), miRNA-196a rs12304647 (OR = 16.01, p =0.001), and TNF-alpha rs1800630 (OR = 79.78, p = 0.001); blood tacrolimus levels at maintenance > 7 ng/ml (OR =7.48, p <0.001); and post-transplant diabetes mellitus (OR = 7.50, p = 0.001). +genetics_GWAS 33291080 hsa-mir-196a Li-Fraumeni syndrome 1 In a multivariate analysis, independent risk factors of PTLF were genetic variation of donor GRP78 rs430397 (OR = 8.99, p = 0.003), GSTP1 rs1695 (OR = 0.13, p = 0.021), miRNA-196a rs12304647 (OR = 16.01, p =0.001), and TNF-alpha rs1800630 (OR = 79.78, p = 0.001); blood tacrolimus levels at maintenance > 7 ng/ml (OR =7.48, p <0.001); and post-transplant diabetes mellitus (OR = 7.50, p = 0.001). +genetics_overexpression_promote 33290872 hsa-mir-638 Liver Neoplasms Furthermore, miR-638 overexpression also leads to a significant (P < 0.05) increase of autophagosomes and autolysosomes in liver cancer cells suggestive of autophagy. +genetics_overexpression_suppress 33290841 hsa-mir-6829 Peripheral Nervous System Diseases Overexpressed chr2:2744228-2,744,407+ in the serum exosomes of MM patients might lead to the downregulation of hsa-miR3p, elevation of GRIN2B in the serum and PC12 cells, and inhibited cell viability. +other 33290828 hsa-mir-15b Acute Kidney Injury Our data concluded that miR-15b and -30a may be promising biomarkers for renal toxicity. +transcription factor target 33290799 hsa-mir-133b Alopecia The expression of miR-133b was abnormally high in AGA patients. In addition, the proliferation of HDPCs was not significantly different between the group cotreated with a Wnt/beta-catenin pathway activator and miR-133b mimic, and the control group (P > 0.05), but the expression of Versican and ALP was suppressed in the cotreatment group (P < 0.05) CONCLUSION: Our data indicated that patients with androgenic alopecia have specific miRNA expression profiles and that the abnormal expression of miR-133b may inactivate the Wnt/beta-catenin pathway and ultimately regulate hair growth. +genetics_overexpression_promote 33290747 hsa-mir-139 Pancreatic Carcinoma Luciferase reporter experiments verified that high level of RalB could reverse the proliferation and invasion of PC cells overexpressing miR-139. +genetics_knock down_promote 33290312 hsa-mir-545 Lung Neoplasms As expected, AFAP1-AS1 knockdown inhibited lung cancer progression via affecting miR +lncRNA target 33290309 hsa-mir-181c Bloom Syndrome And the decreased BSCB permeability and upregulation of tight junction (TJ) protein expression induced by NHO-1 could be partly reversed by the inhibition of SOX5 or miR-181c-5p (+). +lncRNA target 33290275 hsa-mir-24 Pulmonary Disease, Chronic Obstructive 3p increases susceptibility to emphysema through increased BIM and apoptosis. +genetics_overexpression_suppress 33290265 hsa-mir-654 Leukemia, Myeloid, Acute 3p inhibitor or HDGF overexpression. +genetics_overexpression_promote 33290256 hsa-mir-106a Triple Negative Breast Neoplasms Besides, overexpression of HAND2-AS1 reduced the secretion of exo-miR-106a-5p secretion from MSCs, thus suppressed TNBC development. +circulation_biomarker_diagnosis_ns 33290159 hsa-mir-21 Colorectal Neoplasms The serum expression levels of mir-21 and -23a were more predictive of CRC than mir-27a. +circulation_biomarker_diagnosis_up 33290101 hsa-mir-653 Cumulative Trauma Disorders 3p in plasma) differentiated individuals who remained as RIS after 5 years of follow-up. +circulation_biomarker_diagnosis_up 33290101 hsa-mir-448 Cumulative Trauma Disorders 3p in plasma) differentiated individuals who remained as RIS after 5 years of follow-up. +circulation_biomarker_diagnosis_up 33290101 hsa-mir-144 Cumulative Trauma Disorders 3p in plasma) differentiated individuals who remained as RIS after 5 years of follow-up. +other 33289788 hsa-mir-196a Pancreatic Carcinoma The pooled results showed that miR-196a was a valuable diagnostic biomarker in cancer (area under curve (AUC) = 0.87, 95% CI: 0.84-0.90; sensitivity (SEN) = 0.73, 95% CI: 0.64-0.81; specificity (SPE) = 0.90, 95% CI: 0.81-0.95), which was consistent with the data from databases (breast cancer: miR-196a-3p: AUC = 0.77, 95% CI: 0.74-0.79; miR-196a-5p: AUC = 0.71, 95% CI: 0.66-0.75; pancreatic cancer: miR-196a-3p: AUC = 0.80, 95% CI: 0.73-0.87; miR-196a-5p: AUC = 0.61, 95% CI: 0.51-0.71). +other 33289788 hsa-mir-196a Breast Neoplasms The pooled results showed that miR-196a was a valuable diagnostic biomarker in cancer (area under curve (AUC) = 0.87, 95% CI: 0.84-0.90; sensitivity (SEN) = 0.73, 95% CI: 0.64-0.81; specificity (SPE) = 0.90, 95% CI: 0.81-0.95), which was consistent with the data from databases (breast cancer: miR-196a-3p: AUC = 0.77, 95% CI: 0.74-0.79; miR-196a-5p: AUC = 0.71, 95% CI: 0.66-0.75; pancreatic cancer: miR-196a-3p: AUC = 0.80, 95% CI: 0.73-0.87; miR-196a-5p: AUC = 0.61, 95% CI: 0.51-0.71). +circulation_biomarker_diagnosis_ns 33289788 hsa-mir-196a high grade glioma In addition, the pooled result revealed that elevated miR-196a expression in tumor tissues (HR = 2.54, 95% CI: 1.79-3.61, PHeterogeneity=0.000, I2 = 75.8%) or serum/plasma (HR = 4.06, 95% CI: 2.67-6.18, PHeterogeneity=0.668, I2 = 0%) of patients was an unfavorable survival biomarker, which was consistent with the data from databases (adrenocortical carcinoma: HR = 5.70; esophageal carcinoma: HR = 1.93; brain lower grade glioma: HR = 2.91; GSE40267: HR = 2.47, 95% CI: 1.2-5.07; TCGA: HR = 1.82, 95% CI: 1.21-2.74; GSE19783: HR = 4.24, 95% CI: 1-18.06). +circulation_biomarker_diagnosis_ns 33289788 hsa-mir-196a Esophageal Neoplasms In addition, the pooled result revealed that elevated miR-196a expression in tumor tissues (HR = 2.54, 95% CI: 1.79-3.61, PHeterogeneity=0.000, I2 = 75.8%) or serum/plasma (HR = 4.06, 95% CI: 2.67-6.18, PHeterogeneity=0.668, I2 = 0%) of patients was an unfavorable survival biomarker, which was consistent with the data from databases (adrenocortical carcinoma: HR = 5.70; esophageal carcinoma: HR = 1.93; brain lower grade glioma: HR = 2.91; GSE40267: HR = 2.47, 95% CI: 1.2-5.07; TCGA: HR = 1.82, 95% CI: 1.21-2.74; GSE19783: HR = 4.24, 95% CI: 1-18.06). +circulation_biomarker_diagnosis_ns 33289788 hsa-mir-196a Adrenocortical Carcinoma In addition, the pooled result revealed that elevated miR-196a expression in tumor tissues (HR = 2.54, 95% CI: 1.79-3.61, PHeterogeneity=0.000, I2 = 75.8%) or serum/plasma (HR = 4.06, 95% CI: 2.67-6.18, PHeterogeneity=0.668, I2 = 0%) of patients was an unfavorable survival biomarker, which was consistent with the data from databases (adrenocortical carcinoma: HR = 5.70; esophageal carcinoma: HR = 1.93; brain lower grade glioma: HR = 2.91; GSE40267: HR = 2.47, 95% CI: 1.2-5.07; TCGA: HR = 1.82, 95% CI: 1.21-2.74; GSE19783: HR = 4.24, 95% CI: 1-18.06). +genetics_GWAS 33289522 hsa-mir-146a Colorectal Neoplasms Our findings suggest that miR-146a rs2910164 C/G polymorphism is not correlated with the susceptibility of CRC. +lncRNA target 33289184 hsa-mir-34a Diabetic Cardiomyopathies Our results suggest that miR-34a can attenuate myocardial fibrosis in DCM by reducing Type I collagen production, cell viability, and migration and increasing the apoptosis of CFs by targeting Pin-1 signaling. +other 33289096 hsa-mir-126 Acquired Immunodeficiency Syndrome 3p for AHT, respectively. +other 33289096 hsa-mir-144 Acquired Immunodeficiency Syndrome 3p for AHT, respectively. +other 33289016 hsa-mir-1182 Pancreatic Carcinoma In this study, we explored the circ-0050102 expression in pancreatic cancer and its impacts on tumor malignant phenotypes and further investigated the correlations among circ-0050102, miR-1182 and NPSR1. In conclusion, we identified that circ-0050102 played an important role in promoting pancreatic cancer by regulating the miR-1182/NPSR1 pathway. +lncRNA target 33288752 hsa-mir-136 Urinary Bladder Neoplasms The PlncRNA-1/miR-136/smad3 axis provides insights into the regulatory mechanism of BC, thus may serve as a potential therapeutic target and prognostic biomarker for cancer. +genetics_GWAS 33288643 hsa-mir-142 Uterine Cervical Neoplasms CCK-8, flow cytometry, and Transwell assay results revealed that overexpression of miR +lncRNA target 33288559 hsa-mir-139 Prostatic Neoplasms CONCLUSION: These results suggest that miR-139 is inducing autophagic flux blockade leading to apoptosis in prostate cancer cells through the mTOR and Beclin-1 proteins. +circulation_biomarker_prognosis_ns 33288479 hsa-mir-371a Testicular Neoplasms PATIENT SUMMARY The promising novel blood biomarker for testis cancer miR-371a-3p may not provide information at testicle removal, but serial monitoring may lead to earlier detection of relapse. +genetics_overexpression_promote 33287942 hsa-mir-409 Ovarian Neoplasms Through proliferation, migration and colony formation assays, it was revealed that overexpression of miR +transcription factor target 33287939 hsa-mir-196a Uterine Cervical Neoplasms The expression of miR-196a is up-regulated in cervical cancer, and it promotes the growth of cervical cancer by its targeting effect on LRIG3 expression, resulting in enhancement of the proliferation, migration and invasion ability of cervical cancer cells, and inhibition of apoptosis. +genetics_GWAS 33287937 hsa-mir-143 Colorectal Neoplasms Recent studies suggest that single nucleotide polymorphisms rs41291957 and rs353292 in miR-143 may associate with the progression and or development of colorectal cancer. The present study for the first time gave evidence of miR-143 rs41291957 involvement in colorectal cancer patients of Pakistani population. +circRNA target 33287936 hsa-mir-339 Atrial Fibrillation Moreover, the interactions of hsa-miR5p with its related circRNAs and target mRNAs constructed the hub regulatory network in persistent AF by utilizing topology analysis. +genetics_GWAS 33287921 hsa-mir-21 Breast Neoplasms Interestingly the quantitative expression of circulatory mir-21 and mir-155 in the blood plasma of the corresponding patients showed a related pattern with higher expression in malignant samples, therefore can it's clear that PTEN is in the cross-talk of genetics and epigenetic regulation in regard of the development of malignant breast cancer. +genetics_GWAS 33287921 hsa-mir-155 Breast Neoplasms Interestingly the quantitative expression of circulatory mir-21 and mir-155 in the blood plasma of the corresponding patients showed a related pattern with higher expression in malignant samples, therefore can it's clear that PTEN is in the cross-talk of genetics and epigenetic regulation in regard of the development of malignant breast cancer. +other 33287918 hsa-mir-340 Mouth Neoplasms On the predictive analysis of regulators, a series of ncRNAs (including miR-590, CRNDE and miR-340) and transcription factors (including E2F1, MYC and TP53) were identified that have potential important regulatory effects on oral tumors. +genetics_knock down_promote 33287917 hsa-mir-598 Stomach Neoplasms Results circB3GNTL1 can target and control miR-598 expression, and miR-598 can reverse the proliferation, apoptosis, and decomposition of glutamine from gastric cancer cells by knockdown circB3GNTL1. +transcription factor target 33287818 hsa-mir-219c Bladder Fibrosis Thus, a novel antifibrotic function of miR-219c-5p is proposed, which may represent a potential target for the diagnosis and treatment of bladder fibrosis. +other 33287683 hsa-let-7 Lymphoma, Large B-Cell, Diffuse Furthermore, let-7f alone discriminated DLBCL from nonneoplastic tissue in 97% of cases. +other 33287683 hsa-let-7f Lymphoma, Large B-Cell, Diffuse Furthermore, let-7f alone discriminated DLBCL from nonneoplastic tissue in 97% of cases. +genetics_GWAS 33285775 hsa-mir-143 Thyroid Cancer, Papillary In this study, we aimed to investigate the association between 2 functional polymorphisms (ie, rs4705342 and rs353292) in the flanking region of miR-143/145 and risk of PTC.A case-control study including 316 PTC patients and 347 controls was performed. +other 33285775 hsa-mir-145 Thyroid Cancer, Papillary MiR-143 and miR-145 were down-regulated in papillary thyroid carcinoma (PTC) involving in cell proliferation, apoptosis, migration, invasion, and epithelial to mesenchymal transition. +lncRNA target 33285691 hsa-mir-221 Glioma We aimed to systematically evaluate the prognostic role of microRNA 221 in glioma through performing a meta-analysis. +other 33285561 hsa-mir-221 Thyroid Neoplasms In this work, a versatile magnetic bead (MB)-based flow cytometric assay was developed for the detection of hsa-miR3p, which is strongly associated with papillary thyroid carcinoma (PTC). +circRNA target 33285422 hsa-mir-184 Ovarian Neoplasms CONCLUSION: Circ_0025033 promotes the progression of OC by regulating LSM4 expression via targeting miR-184, which provided a new strategy to treat OC. +other 33285367 hsa-mir-122 Colorectal Neoplasms Six miRNA were significantly increased after CRC resection (miR-324, let7b, miR-454, miR-374a, miR-122, miR-19b, all p<0.05), while three miRNAs were significantly increased following CAA resection (miR-454, miR-374a, miR-122, all p<0.05). +other 33285367 hsa-mir-374a Colorectal Neoplasms Six miRNA were significantly increased after CRC resection (miR-324, let7b, miR-454, miR-374a, miR-122, miR-19b, all p<0.05), while three miRNAs were significantly increased following CAA resection (miR-454, miR-374a, miR-122, all p<0.05). +other 33285367 hsa-mir-24 Colorectal Neoplasms Six miRNA were significantly increased after CRC resection (miR-324, let7b, miR-454, miR-374a, miR-122, miR-19b, all p<0.05), while three miRNAs were significantly increased following CAA resection (miR-454, miR-374a, miR-122, all p<0.05). +other 33285367 hsa-mir-454 Colorectal Neoplasms Six miRNA were significantly increased after CRC resection (miR-324, let7b, miR-454, miR-374a, miR-122, miR-19b, all p<0.05), while three miRNAs were significantly increased following CAA resection (miR-454, miR-374a, miR-122, all p<0.05). +other 33285367 hsa-mir-19b Colorectal Neoplasms Six miRNA were significantly increased after CRC resection (miR-324, let7b, miR-454, miR-374a, miR-122, miR-19b, all p<0.05), while three miRNAs were significantly increased following CAA resection (miR-454, miR-374a, miR-122, all p<0.05). +other 33285367 hsa-let-7b Colorectal Neoplasms Six miRNA were significantly increased after CRC resection (miR-324, let7b, miR-454, miR-374a, miR-122, miR-19b, all p<0.05), while three miRNAs were significantly increased following CAA resection (miR-454, miR-374a, miR-122, all p<0.05). +target gene 33284890 hsa-mir-770 Stomach Neoplasms Circular RNA circ_ASAP2 promotes cell viability, migration, and invasion of gastric cancer cells by regulating the miR-770-5p/CDK6 axis. +circulation_biomarker_prognosis_ns 33284712 hsa-mir-22 Osteosarcoma CONCLUSIONS: Altered plasma levels of miR-22 might serve as a novel, noninvasive biomarker for OS diagnosis, prognosis, and chemosensitivity prediction. +transcription factor target 33284571 hsa-mir-149 Asthma Taken together, we strongly supported that miR-149 might be a key inhibitor of asthma by targeting TRMP7. +genetics_overexpression_promote 33283947 hsa-mir-429 Neurotoxicity Syndromes Rescue assays revealed that overexpression of BAG5 reversed the suppressive effects of miR-429 upregulation on ketamine-induced neurotoxicity in PC12 cells. +genetics_knock down_promote 33283885 hsa-mir-758 Leukemia, Myeloid, Acute Circ_0002483 knockdown repressed AML cell proliferation and promoted cycle arrest and apoptosis via controlling miR +other 33283723 hsa-mir-155 Lymphoma, Non-Hodgkin 5p in NHL cell lines were examined by qRT-PCR. +transcription factor target 33283710 hsa-mir-29b Leukemia, Myeloid, Acute CONCLUSION: MiR-29b-3p can inhibit the proliferation and induce apoptosis of AML cells by down-regulating STAT3. +genetics_knock down_promote 33283704 hsa-mir-125a Leukemia In the newly treatment ANLL patients, the expression level of miR-125a showed negatively correlated with LDH level and the ratio of immature cells (r=-0.454, r=-0.400), but not with sex, degree of risk, peripheral blood leukocyte count, platelet count, hemoglobin content, WT1, CRP, etc. +other 33283668 hsa-mir-637 Atherosclerosis CONCLUSIONS: MiR-637 is a potential noninvasive diagnostic marker of atherosclerosis and has important predictive value for the occurrence of future cardiovascular events. +other 33283668 hsa-mir-637 Cardiovascular Diseases CONCLUSIONS: MiR-637 is a potential noninvasive diagnostic marker of atherosclerosis and has important predictive value for the occurrence of future cardiovascular events. +genetics_overexpression_promote 33283616 hsa-mir-380 Urinary Bladder Neoplasms 3p overexpression dramatically reverses the roles of circ_0004463 overexpression. +lncRNA target 33283483 hsa-mir-19a Inflammation CONCLUSION: Differentiation antagonizing non-protein coding RNA silencing could protect human chondrocyte cells against LPS-induced inflammatory injury and apoptosis through targeting miR-19a, suggesting a vital role of the DANCR/miR-19a axis in OA. +other 33283469 hsa-mir-181c Diabetes Mellitus The miR-181c and miR-375 might be regarded as potential predictors for fracture, while miR5p might be a candidate diagnostic biomarker for diabetic fracture. +other 33283469 hsa-mir-375 Diabetes Mellitus The miR-181c and miR-375 might be regarded as potential predictors for fracture, while miR5p might be a candidate diagnostic biomarker for diabetic fracture. +other 33283469 hsa-mir-155 Diabetes Mellitus Moreover, the miRNA-lncRNA analysis revealed that miR5p regulated by lncRNA MIR155HG was up-regulated in FH group; in addition, the miR-181c was significantly up-regulated and miR-375 was observably down-regulated in DFH group. +other 33283391 hsa-mir-217 Diabetes Mellitus miR-217 was found to be upregulated in VSMCs treated by high glucose and aorta VSMCs of diabetic rats. +circulation_biomarker_diagnosis_ns 33283362 hsa-mir-182 Breast Neoplasms We evaluated the expression of the miR-182 cluster (miR-96, 182, and 183) in peripheral blood mononuclear cells (PBMCs) of patients with breast cancer (BC), and T cell polarization by the expression of FOXO1, NFATs, ITK, TCR/CD3 complex, and IL-2/IL-2RA. +circulation_biomarker_diagnosis_ns 33283362 hsa-mir-96 Breast Neoplasms We evaluated the expression of the miR-182 cluster (miR-96, 182, and 183) in peripheral blood mononuclear cells (PBMCs) of patients with breast cancer (BC), and T cell polarization by the expression of FOXO1, NFATs, ITK, TCR/CD3 complex, and IL-2/IL-2RA. +genetics_knock down_suppress 33282949 hsa-mir-181c Urinary Bladder Neoplasms CONCLUSION: Collectively, this study reveals that knockdown of LUCAT1 inhibits the migration and invasion of bladder cancer cells in a miR-181c-5p-dependent manner, which may be related to KRAS downregulation. +other 33282943 hsa-mir-204 Muscular Diseases In the present study, we found that miR-204 is downregulated after skeletal muscle injury. +other 33282861 hsa-mir-9 Breast Neoplasms miR-9-5p as a Regulator of the Androgen Receptor Pathway in Breast Cancer Cell Lines. +lncRNA target 33282723 hsa-mir-27a Carcinoma, Non-Small-Cell Lung Mechanistic analysis indicates that LINC01089 acts as a sponge for miR-27a, regulating its expression in NSCLC. Interestingly, LINC01089 mediated the upregulation of SFRP1 expression by inhibiting the Wnt/beta-catenin-EMT pathway and inhibiting the epithelial-mesenchymal transition of NSCLC via sponging miR-27a. +other 33282547 hsa-mir-147b Adenocarcinoma of Lung Also, there were significantly negative expression correlations between miR-147b and WDR82, between miR-224 and PRPF4B, as well as between miR-31 and NR3C2 in LUAD samples. +other 33282547 hsa-mir-224 Adenocarcinoma of Lung Also, there were significantly negative expression correlations between miR-147b and WDR82, between miR-224 and PRPF4B, as well as between miR-31 and NR3C2 in LUAD samples. +other 33282547 hsa-mir-1 Adenocarcinoma of Lung Also, there were significantly negative expression correlations between miR-147b and WDR82, between miR-224 and PRPF4B, as well as between miR-31 and NR3C2 in LUAD samples. +lncRNA target 33282292 hsa-mir-223 Eosinophilic Esophagitis METHODS: The expression of miR-223 and the validated miR-223 target insulin-like growth factor receptor 1 (IGF1R) protein was determined in our paediatric cohort of EoE patients. +other 33282009 hsa-mir-216a Atherosclerosis MiR-216a and Smad7 expression in vivo were measured using human carotid atherosclerotic plaques of the patients who underwent carotid endarterectomy (n = 41). In human carotid atherosclerotic plaques, Smad7 level was remarkably decreased in high miR-216a group compared with low miR-216a group. +lncRNA target 33281971 hsa-mir-296 Adenocarcinoma of Lung Subsequently, CD44, cyclin D3 (CCND3), neurocalcin delta (NCALD), microtubule actin crosslinking factor 1 (MACF1) and potassium channel tetramerization domain containing 15 were obtained by intersecting the predicted target genes of miR +circRNA target 33281969 hsa-mir-590 Glioma 5p-APC ceRNA axes may be potential targets for the treatment of glioma. +other 33281969 hsa-mir-142 Glioma 5p was upregulated and APC was downregulated. +circRNA target 33281969 hsa-mir-590 Adenomatous Polyposis Coli 5p-APC ceRNA axes may be potential targets for the treatment of glioma. +other 33281969 hsa-mir-142 Adenomatous Polyposis Coli 5p was upregulated and APC was downregulated. +circulation_biomarker_diagnosis_ns 33281965 hsa-mir-125a Uterine Cervical Neoplasms Receiver operating characteristic (ROC) curve analyses were performed and the results revealed that the level of plasma exosomal miR-125a-5p was a potential marker for differentiating between non-cervical cancer and cervical cancer, with an ROC area under the curve of 0.7129. +other 33281961 hsa-mir-29b Leukemia, Monocytic, Acute Among these hubs, miR-29b-3p, MYC, TP53 and NFKB1 were determined to be potential AMoL regulators, and were subsequently extracted to construct sub-networks. A hypothetical pathway model was also proposed for miR-29b-3p to reveal the potential co-regulatory mechanisms of miR-29b-3p, MYC, TP53 and NFKB1 in AMoL. +lncRNA target 33281873 hsa-mir-619 Retinoblastoma 5p inhibitor. +other 33281794 hsa-mir-126 Cryptococcosis Taken together, our results reveal the role of circRNA-1806/miRNA-126 in the regulation of cell cycle and apoptosis in cryptococcal infection and can provide a new insights of the pathogenesis of cryptococcal infection. +other 33281788 hsa-mir-16 Influenza, Human Here, we show that expression of NS1 from the WSN strain, but not PR8 strain, of IAV, markedly induced nuclear import of the host RNA interference (RNAi) factors such as Argonaute-2 and microRNA 16. +other 33281788 hsa-mir-16 Leukokeratosis, Hereditary Mucosal Here, we show that expression of NS1 from the WSN strain, but not PR8 strain, of IAV, markedly induced nuclear import of the host RNA interference (RNAi) factors such as Argonaute-2 and microRNA 16. +transcription factor target 33280610 hsa-mir-210 Carcinoma, Hepatocellular Targeting miR5P-ATAD3A axis is a novel therapeutic target for sorafenib-resistant HCC. +genetics_overexpression_promote 33280526 hsa-mir-214 Carcinoma, Squamous Cell, Cutaneous Moreover, VEGFA and Bcl-2 overexpression reversed the anti-tumor phenotypes of miR-214 on CSCC cells. +transcription factor target 33280520 hsa-mir-200 Breast Neoplasms IL-8 promoted EMT via downregulation of miR-200 family expression in breast cancer cells and increases tumor cell migration and invasion. +genetics_overexpression_promote 33280517 hsa-mir-376c Carcinoma, Non-Small-Cell Lung CONCLUSION: EC-delivered Evs inhibit YTHDF1 expression and the Wnt/beta-catenin pathway induction via miR-376c overexpression, thus inhibiting the malignant phenotypes of NSCLC cells. +transcription factor target 33280497 hsa-mir-27a Carcinoma, Non-Small-Cell Lung Apart from that, the miR-27a-3p can inhibit the expression of MAP17 to suppress the NSCLC progression. +other 33280362 hsa-mir-126 Diabetes Mellitus Objective: To explore the effects of microRNA-126 (miR-126) on the proliferation of human myeloid leukemia mononuclear cells (THP-1)-derived macrophages in high glucose environment and the regulatory role of miR-126 in periodontitis with diabetes. +other 33280362 hsa-mir-126 Periodontitis Objective: To explore the effects of microRNA-126 (miR-126) on the proliferation of human myeloid leukemia mononuclear cells (THP-1)-derived macrophages in high glucose environment and the regulatory role of miR-126 in periodontitis with diabetes. +circulation_biomarker_diagnosis_down 33279668 hsa-mir-31 Alzheimer Disease CONCLUSION: The data of this study indicated that serum expression of miR +genetics_overexpression_suppress 33279663 hsa-mir-374b Alzheimer Disease MAGI2-AS3 reduction enhanced neuronal viability and attenuated neuroinflammation in AD cell models, and miR-374b-5p overexpression led to same effects, but miR-374b-5p inhibition reversed these effects. +other 33279591 hsa-mir-150 Coronary Disease qRT-PCR results suggest that the expression of lncRNA ENST00000609755.1 and ELK1 were up-regulated in CHD group and positively correlated, the expression of miR-150 was down-regulated in CHD, which was negatively correlated with lncRNA ENST00000609755.1 and ELK1. CONCLUSION: LncRNA ENST00000609755.1, miR-150 and ELK1 may have a potential ceRNA regulatory network relationship which could be considered to have a good combined diagnostic value for CHD. +genetics_GWAS 33279585 hsa-mir-127 Fibrosis Hence, miR3p emerges as an epigenetic activator regulating the transition from repair to remodeling during skin wound healing but may also induce age-related defects, pathological scarring, and fibrosis, all linked to myofibroblast senescence. +other 33278692 hsa-mir-23b Distal arthrogryposis type 2B While no alterations in diameter and concentration were detected in sEVs on D+7 between CON and SHS groups, three sEVs-miRNAs (miR-23b-5p, -489 and -1248) were down-regulated in SHS bulls compared to CON on D+7; other three (miR5p, -656 and -1307) displayed a tendency (0.05 < P < 0.10) to be altered. +other 33278692 hsa-mir-126 Distal arthrogryposis type 2B While no alterations in diameter and concentration were detected in sEVs on D+7 between CON and SHS groups, three sEVs-miRNAs (miR-23b-5p, -489 and -1248) were down-regulated in SHS bulls compared to CON on D+7; other three (miR5p, -656 and -1307) displayed a tendency (0.05 < P < 0.10) to be altered. +circulation_biomarker_diagnosis_up 33278550 hsa-mir-184 Abortion, Habitual While its association with RPL was reported earlier, this study is also the first to report on the upregulation of Hsa-miR-184 in circulating fluids in association with RPL. +lncRNA target 33278507 hsa-mir-20b Alzheimer Disease Therefore, miR-20b-5p may be a perspective curative target for AD. +lncRNA target 33278425 hsa-mir-515 Choriocarcinoma CONCLUSIONS: The low expression of LOXL1-AS1 inhibits the proliferation and migration of human choriocarcinoma cells, which might be related to miR +transcription factor target 33278397 hsa-mir-122 Plaque, Atherosclerotic Herein, we aim to determine whether miR-122 is involved in EndMT and the underlying mechanism in atherosclerosis. SIGNIFICANCE: Inhibition of miR-122 prevents atherosclerosis and regulates NPAS3-mediated EndMT, suggesting that miR-122 may be a novel target in the treatment of EndMT-associated diseases including atherosclerosis. +transcription factor target 33278394 hsa-mir-223 Influenza, Human STIM1/miR-223/NLRP3 axis modulated IAV-induced inflammation injury of lung epithelial cells. SIGNIFICANCE: Our evidence indicated that silencing STIM1 alleviated IAV-induced inflammation injury of lung epithelial cells by inactivating NLRP3 and inflammasome via promoting miR-223 expression. +transcription factor target 33278391 hsa-mir-499a Breast Neoplasms In this study, we investigated the effect of ursolic acid (UA), a natural triterpene, on breast CSCs enriched from breast cancer cell lines, MCF7, MDA-MB-231 and T47D and analysed the interplay of the Wnt inhibitor, sFRP4 and an miRNA, miR-499a-5p, in mediating the effect of UA. +other 33278191 hsa-mir-25 Coronary Disease SNHG14 and KLF4 were upregulated, whereas miR3p was downregulated in hypoxia-induced H9c2 cells and cardiac tissues of patients with CCHD compared with their controls. +other 33278191 hsa-mir-25 Congenital central hypoventilation syndrome SNHG14 and KLF4 were upregulated, whereas miR3p was downregulated in hypoxia-induced H9c2 cells and cardiac tissues of patients with CCHD compared with their controls. +genetics_overexpression_promote 33277957 hsa-mir-335 Plaque, Atherosclerotic CONCLUSIONS: Overexpression of miR +genetics_overexpression_promote 33277957 hsa-mir-335 Acute Coronary Syndrome CONCLUSIONS: Overexpression of miR +circulation_biomarker_prognosis_ns 33277877 hsa-mir-27a Carcinoma, Squamous Cell, Skin CONCLUSIONS: The expression of miR-27a in tissue and serum was higher in patients with skin squamous cell carcinoma compared with healthy controls and was closely related to some pathological data of skin cancer. +other 33277874 hsa-mir-3977 Thymoma METHODS: We identified a series of non-coding (nc) RNAs (including BCL11A, miR-3977, miR-4460 and miR3p) and TF (FAM185A, MGAM2, SEC14L4, ACTBL2), and predicted transcription factors (including AHR, ATF4, CEBPA and DDIT3) that have significant regulatory effects on the module by difference analysis, co-expression analysis, enrichment analysis of thymoma gene expression profiling and using hypergeometric test to calculate the potential regulatory effects of multiple factors on the module. +other 33277874 hsa-mir-4460 Thymoma METHODS: We identified a series of non-coding (nc) RNAs (including BCL11A, miR-3977, miR-4460 and miR3p) and TF (FAM185A, MGAM2, SEC14L4, ACTBL2), and predicted transcription factors (including AHR, ATF4, CEBPA and DDIT3) that have significant regulatory effects on the module by difference analysis, co-expression analysis, enrichment analysis of thymoma gene expression profiling and using hypergeometric test to calculate the potential regulatory effects of multiple factors on the module. +other 33277874 hsa-mir-542 Thymoma METHODS: We identified a series of non-coding (nc) RNAs (including BCL11A, miR-3977, miR-4460 and miR3p) and TF (FAM185A, MGAM2, SEC14L4, ACTBL2), and predicted transcription factors (including AHR, ATF4, CEBPA and DDIT3) that have significant regulatory effects on the module by difference analysis, co-expression analysis, enrichment analysis of thymoma gene expression profiling and using hypergeometric test to calculate the potential regulatory effects of multiple factors on the module. +other 33277871 hsa-mir-26a Uveal melanoma PURPOSE: To study the effect of micro ribonucleic acid (miR)-26a on the proliferation and apoptosis of uveal melanoma (UM) cell lines, and to explore the potential signaling pathway. METHODS: UM SP6.5 cells were used in this study, and were transfected with miR-26a mimic (miR-26a mimic group) and miR-26a small-interfering RNA (siRNA) (miR-26a siRNA group) using Lipofectamine 2000 transfection reagent, with miR-26a negative control (NC) as the blank controls (miR-26a NC group). +lncRNA target 33277866 hsa-mir-488 Carcinoma, Hepatocellular CONCLUSION: LncRNA XIST accelerates HCC cell growth by inhibiting miR-488, so inhibiting lncRNA XIST or up-regulating miR-488 has objective potential therapeutic value and may be helpful for the development of new HCC treatment strategies. +circulation_biomarker_prognosis_up 33277853 hsa-mir-195 Stomach Neoplasms CONCLUSION: Serum miR +genetics_overexpression_promote 33277846 hsa-mir-182 Ovarian Neoplasms 5p overexpressed ovarian cancer cells successfully recovered the cisplatin resistance. +transcription factor target 33277838 hsa-mir-1 Breast Neoplasms Additionally, miR-1 also suppressed the chemosensitivity of the MBA-MD-1 breast cancer cells to cisplatin. +other 33277837 hsa-mir-128 Colorectal Neoplasms METHODS: The levels of PVT1-214, microRNA (miR)-128, and interferon regulatory factor-1 (IRF-1) in CRC tissues and cell lines were evaluated by quantitative real-time polymerase chain reaction (qRT-PCR). +other 33277756 hsa-mir-509 Breast Neoplasms CONCLUSIONS: Overall, our data indicate that the circ-PRMT5/miR3p/TCF7L2 axis can aggravate the malignant character of breast cancer cells by the regulation of the PI3K/AKT pathway. +lncRNA target 33277615 hsa-mir-513c Carcinoma, Hepatocellular In vivo experiments verified that lncRNA DLX6-AS1 promoted the progression of HCC through the miR-513c/Cul4A/ANXA10 axis. +other 33277569 hsa-mir-15b Carcinoma, Renal Cell Subsequently, we developed an algorithm to establish which miRNAs are more likely to be found in the urine of ccRCC patients that indicated miR-122, miR-1271, and miR-15b as potential interesting markers. +other 33277569 hsa-mir-122 Carcinoma, Renal Cell Subsequently, we developed an algorithm to establish which miRNAs are more likely to be found in the urine of ccRCC patients that indicated miR-122, miR-1271, and miR-15b as potential interesting markers. +transcription factor target 33277385 hsa-mir-122a Liver Injury Ad-E4-122aT-CAL2 harbors sequences complementary to the liver-specific miR-122a in the 3' untranslated region of E4, leading to significant suppression of leaky Ad gene expression in the liver via posttranscriptional gene silencing and a significant reduction in late-phase hepatotoxicity. +genetics_overexpression_promote 33276753 hsa-mir-377 Carcinoma, Non-Small-Cell Lung Consistently, overexpression of hsa_circRNA_103809 increased cisplatin-resistance in CS-NSCLC cells by regulating the miR +lncRNA target 33276722 hsa-mir-199a Cataract MiR-199a was downregulated in diabetic cataract capsule and hyperglycemia-conditioned human LECs. CONCLUSION: Our findings implied miR-199a could be a therapeutic target by regulating SP1 directly to affect EMT in diabetic cataract and provided novel insights into the pathogenesis of diabetic cataract. +epigenetics 33276362 hsa-mir-9 Ovarian Neoplasms In addition, when analyzing these five genes, a significant association of the methylation level of the MIR9-1 gene with a decrease in the three-year relapse-free survival, and a trend for decrease in the three-year survival rate with the methylation level of the MIR124-2 gene of OC patients were determined. Thus, the first data suggesting the role of inhibitors of the sPD-L1 immune checkpoint for five miRNAs (miR-124, miR-34b, miR-34c, miR-9, miR-339) and the possibility of using hypermethylated MIR9-1 and, presumably, MIR124-2 genes as independent prognostic markers of poor disease-free survival in OC patients were obtained. +epigenetics 33276362 hsa-mir-124-2 Ovarian Neoplasms In addition, when analyzing these five genes, a significant association of the methylation level of the MIR9-1 gene with a decrease in the three-year relapse-free survival, and a trend for decrease in the three-year survival rate with the methylation level of the MIR124-2 gene of OC patients were determined. Thus, the first data suggesting the role of inhibitors of the sPD-L1 immune checkpoint for five miRNAs (miR-124, miR-34b, miR-34c, miR-9, miR-339) and the possibility of using hypermethylated MIR9-1 and, presumably, MIR124-2 genes as independent prognostic markers of poor disease-free survival in OC patients were obtained. +epigenetics 33276362 hsa-mir-9-1 Ovarian Neoplasms In addition, when analyzing these five genes, a significant association of the methylation level of the MIR9-1 gene with a decrease in the three-year relapse-free survival, and a trend for decrease in the three-year survival rate with the methylation level of the MIR124-2 gene of OC patients were determined. Thus, the first data suggesting the role of inhibitors of the sPD-L1 immune checkpoint for five miRNAs (miR-124, miR-34b, miR-34c, miR-9, miR-339) and the possibility of using hypermethylated MIR9-1 and, presumably, MIR124-2 genes as independent prognostic markers of poor disease-free survival in OC patients were obtained. +lncRNA target 33276305 hsa-mir-221 Ischemic Stroke CONCLUSION: our results indicate that miR-221 could decrease brain damage in the setting of acute ischemic stroke by inhibiting the proinflammatory response, which furthered our understanding of the molecular basis of miR-221 and provided a new potential therapeutic target for the treatment of ischemic stroke . +exosome 33275988 hsa-mir-124 Hypertension, Pulmonary In summary, our findings suggest that hUCB-MSC-derived exosomal miR-124 could promote rat liver regeneration after PH via downregulating Foxg1. +exosome 33275988 hsa-mir-124 Liver Diseases In summary, our findings suggest that hUCB-MSC-derived exosomal miR-124 could promote rat liver regeneration after PH via downregulating Foxg1. +genetics_overexpression_promote 33275986 hsa-mir-1278 Myocardial Ischemia SIGNIFICANCE: Collectively, our findings illustrate that the expression of miR-1278 is low in H(2)O(2)-treated NMVCs and post-MI cardiac tissues, and the overexpression of miR-1278 in these protects against cell death by modulating IL-22 and CXCL14 expression. +transcription factor target 33275947 hsa-mir-151 Ataxia Telangiectasia 3p enhanced the neuroprotective effect of Dex against A by targeting DAPK-1 and TP53. +transcription factor target 33275947 hsa-mir-151 Amyloidosis Up-regulation of miRNA3p enhanced the neuroprotective effect of dexmedetomidine against -amyloid by targeting DAPK-1 and TP53. +other 33275252 hsa-mir-203 Dermatitis, Atopic Finally, miR-203 may reflect the extent of inflammation in AD, in parallel with the tumor necrosis factor pathway and immunoglobulin E levels. CONCLUSIONS: MicroRNAs are easily identifiable molecules in a variety of cells and body fluids that may be useful as diagnostic (miR-155 and miR-146a) and disease severity (miR-203) biomarkers in patients with AD. +lncRNA target 33275250 hsa-mir-708 Reperfusion Injury, Cerebral Ischemia Influences of miR-708 on cerebral ischemia-reperfusion injury through targeted regulation of ADAM17. CONCLUSIONS MiR-708 can modulate ADAM17 in a targeted manner to affect cellular proliferation and apoptosis in cerebral ischemia-reperfusion injury. +circulation_biomarker_prognosis_up 33275245 hsa-mir-136 Arthritis, Rheumatoid RESULTS: It was found that microRNA-136 expression was remarkably elevated in peripheral blood serum of patients with EH, and the expression levels of biochemical markers of RASS, such as ACE, RA, Ang II, and ALD were also found higher than those in healthy controls. +circulation_biomarker_prognosis_up 33275245 hsa-mir-136 Essential Hypertension RESULTS: It was found that microRNA-136 expression was remarkably elevated in peripheral blood serum of patients with EH, and the expression levels of biochemical markers of RASS, such as ACE, RA, Ang II, and ALD were also found higher than those in healthy controls. +transcription factor target 33275235 hsa-mir-34a Arthritis, Rheumatoid In this study, we intended to study the role and mechanism of miR-34a-5p in the development of RA. RESULTS: We found that miR-34a-5p expression is lower in RA synovial tissue compared to osteoarthritis (OA). +transcription factor target 33275235 hsa-mir-34a Osteoarthritis RESULTS: We found that miR-34a-5p expression is lower in RA synovial tissue compared to osteoarthritis (OA). +other 33275235 hsa-mir-34a Inflammation Previous studies have found that microRNA-34a-5p (miR-34a-5p) is involved in the development of many inflammatory diseases. +genetics_overexpression_promote 33275234 hsa-mir-376a Glioma Besides, overexpression of miR-376a-3p suppressed proliferative and metastatic capacities of glioma cells. +genetics_knock down_promote 33275233 hsa-mir-1301 Glioblastoma The knockdown of TMBIM6 reversed the stimulation effects of PVT1 on GBM cell malignancy behaviors with miR +genetics_knock down_promote 33275232 hsa-mir-20a Breast Neoplasms The knockdown of LAMTOR3 expression repressed the influence of miR-20a on the proliferation of breast cancer cells. +lncRNA target 33275231 hsa-mir-634 Breast Neoplasms ZBTB20 pathway may be a potential target for the treatment of breast cancers. +lncRNA target 33275226 hsa-mir-4429 Colorectal Neoplasms The depletion of PSMA3-AS1 inhibited CRC progression, which was neutralized by miR-4429 inhibitor. +other 33275223 hsa-mir-20a Liver Neoplasms OBJECTIVE: The aim of this study was to explore the regulatory effect of micro ribonucleic acid (miR)-20a on nuclear factor-kappaB (NF-small ka, CyrillicB) in liver cancer Huh-7 cells, and to elucidate its influence on the chemosensitivity of Huh-7 cells. CONCLUSIONS: MiR-20a up-regulates the expressions of the downstream proteins Livin and Survivin, decreases the expressions of apoptosis-associated proteins, weakens the sensitivity of cells to chemotherapy drugs and lowers the apoptosis level of cells by activating the NF-small ka, CyrillicB signaling pathway in liver cancer Huh-7 cells. +lncRNA target 33275219 hsa-mir-449b Carcinoma, Endometrioid This study aims to illustrate the role of miR-449b-5p in inhibiting proliferative capacity of endometrial carcinoma (EC) by targeting MDM4. +transcription factor target 33274736 hsa-mir-409 Primary Myelofibrosis Further, miR3p suppressed SCAI expression, but SCAI up-regulation suppressed the osteoblastic differentiation, as well as reduced the relative mRNA/protein expression of Wnt/beta-catenin signaling pathway-related genes (Axis inhibition protein 1 (AXIN1), beta-catenin, Lymphoid Enhancer Binding Factor 1, Cellular-myelocytomatosis (c-myc) and cyclin D1). +lncRNA target 33274684 hsa-mir-195 Schizophrenia CONCLUSIONS: Our data indicate that microRNA-195 level may predict symptomatic improvement and olanzapine response in schizophrenia patients, suggesting that microRNA-195 should be considered as a potential therapeutic target for antipsychotics. +circulation_biomarker_diagnosis_down 33274678 hsa-mir-214 Scleroderma, Systemic Both, YKL-40 concentrations and miR-214 plasma fold change values might serve as possible biomarkers in SSc. +circulation_biomarker_diagnosis_up 33274565 hsa-mir-550a Breast Neoplasms The study was to explore the effect of long non-coding RNA LINC00261/microRNA (miR)-550a-3p/serum deprivation response (SDPR) axis on the biological characteristics of BC stem cells (BCSCs). +lncRNA target 33274232 hsa-mir-148b Melanoma Moreover, tumor growth and metastasis experiments showed that miR-148b could significantly suppress proliferation and metastasis of melanoma in vivo. +exosome 33274193 hsa-mir-22 Nasal Polyps 3p was upregulated in NLF-derived exosomes from CRSwNP. +exosome 33274193 hsa-mir-22 Nasopharyngitis 3p was upregulated in NLF-derived exosomes from CRSwNP. +transcription factor target 33274182 hsa-mir-27a Polycystic Ovary Syndrome It seems that dysregulated expression of miR-27a, miR-130b, and miR-301a are associated with PCOS. MiR-27a has a potential to serve as a diagnostic biomarker of PCOS. +transcription factor target 33274181 hsa-mir-181a Epilepsy The aim of this study was to explore the possible role of miR-125a and miR-181a as regulators of inflammation in epilepsy through investigating their involvement in the pathogenesis of epilepsy, and their correlation with the levels of inflammatory cytokines. +transcription factor target 33274181 hsa-mir-125a Epilepsy The aim of this study was to explore the possible role of miR-125a and miR-181a as regulators of inflammation in epilepsy through investigating their involvement in the pathogenesis of epilepsy, and their correlation with the levels of inflammatory cytokines. +other 33274007 hsa-mir-204 Cardiovascular Diseases miR-204 is a newly discovered miRNA with many protective effects on cardiovascular diseases. +other 33274007 hsa-mir-204 Cardiomyopathies Our study is aimed at investigating the effect of miR-204 on DOX-induced myocardial injury. +genetics_overexpression_suppress 33274007 hsa-mir-204 Heart Injuries Moreover, the overexpression of HMGB1 could offset the protective effects of miR-204 against DOX-induced cardiac injury. +transcription factor target 33273900 hsa-mir-223 Breast Neoplasms 3p in the MCF7 cancer cell line was studied when exposed to ZnO nanoparticles synthesized through a green route. +transcription factor target 33273900 hsa-mir-155 Breast Neoplasms 3p in the MCF7 cancer cell line was studied when exposed to ZnO nanoparticles synthesized through a green route. +transcription factor target 33273900 hsa-mir-203a Breast Neoplasms 3p in the MCF7 cancer cell line was studied when exposed to ZnO nanoparticles synthesized through a green route. +genetics_overexpression_promote 33273862 hsa-mir-21 Uveal melanoma Additionally, as a competitive endogenous RNA (ceRNA), GAS5 directly binded to the oncogenic miR-21 in UM cells, and overexpression of miR-21 attenuated the EMT-suppressing effect of GAS5. +other 33273858 hsa-mir-200c Stomach Neoplasms MicroRNA-200c Nanoparticles Sensitized Gastric Cancer Cells to Radiotherapy by Regulating PD-L1 Expression and EMT. +genetics_overexpression_promote 33273855 hsa-mir-1276 Colonic Neoplasms Furthermore, overexpression of miR-1276 in colon cancer cells increased proliferation, migration, invasiveness and EMT, and decreased autophagy and apoptosis. +lncRNA target 33273850 hsa-mir-146b Breast Neoplasms A2M-AS1 accelerated BC cell proliferation, invasion, and colony formation and suppressed apoptosis via the miR-146b/MUC19/Hippo axis, which was confirmed in vivo. +genetics_knock down_promote 33273841 hsa-mir-21 Fibrosis Additionally, these effects of miR-21 KO on fibrosis were reversed by siRNA-mediated knockdown of Spry1. +transcription factor target 33273841 hsa-mir-21 Endomyocardial Fibrosis Therefore, targeting the miR +transcription factor target 33273841 hsa-mir-21 Cardiomyopathies Therefore, targeting the miR +target gene 33273832 hsa-let-7a Carcinoma, Hepatocellular let-7a-5p Inhibits Invasion and Migration of Hepatoma Cells by Regulating BZW2 Expression. +lncRNA target 33273826 hsa-mir-424 Stomach Neoplasms 3p could be a potential target for the treatment of GC. +other 33272890 hsa-mir-375 Stomach Neoplasms MicroRNA-375 reverses the expression of PD-L1 by inactivating the JAK2/STAT3 signaling pathways in gastric cancer. +genetics_knock down_promote 33272103 hsa-mir-125b Carcinoma, Hepatocellular Knockdown of miR-125b-5p could reverse the inhibitory effects of sh-DANCR on HCC cells. +lncRNA target 33272009 hsa-mir-519e Thyroid Neoplasms Ultimately, our study revealed that MAPKAPK5-AS1 promotes proliferation and migration of thyroid cancer cells by targeting the miR-519e-5p/YWHAH axis, which provides novel insight into the development and progression of thyroid cancer. +circulation_biomarker_diagnosis_up 33271553 hsa-mir-451a Asthma Herein, our microarray data indicated that microRNA-451a-5p (miRNA-451a) expression decreased by 4.6-fold and ETS proto-oncogene 1 (ETS1) increased by 2.2-fold in the peripheral blood lymphocytes isolated from asthmatic children (n = 4) as compared to control individuals (n = 4). Collectively, our work demonstrates that downregulation of miRNA-451a upregulates ETS1 expression in CD4+ T cells, which may contribute to Th2 cell differentiation in pediatric asthma. +other 33271241 hsa-mir-706 Diabetes Mellitus CircRNA-Krt13/miR3p/Itga3 and circRNA-Krt14/miR-706/Mylk4 pathways were built, which may contribute to the healing of SJHY formula-treated diabetic wounds. +other 33271241 hsa-mir-665 Diabetes Mellitus CircRNA-Krt13/miR3p/Itga3 and circRNA-Krt14/miR-706/Mylk4 pathways were built, which may contribute to the healing of SJHY formula-treated diabetic wounds. +genetics_overexpression_promote 33270982 hsa-mir-15a Leukemia, Myeloid, Acute 5p are overexpressed in a subgroup of chemoresistant AML patients. +genetics_overexpression_promote 33270982 hsa-mir-21 Leukemia, Myeloid, Acute 5p are overexpressed in a subgroup of chemoresistant AML patients. +lncRNA target 33270831 hsa-mir-26b Soft Tissue Injuries In conclusion, this study revealed that HDBD relieved acute STI via modulating miR-26b-5p/COX2 axis to inhibit inflammation. +transcription factor target 33270501 hsa-mir-142 Lung Neoplasms 5p may regulate the expressions of EMT-related proteins by targeting YY1, thereby inhibiting lung cancer metastasis, which provides a promising therapeutic target for lung cancer. +lncRNA target 33270361 hsa-mir-2355 Heart Failure CONCLUSIONS: Silencing SOX2-OT alleviated cardiac dysfunction in rats by reducing the activation of NLRP3 inflammasomes via regulating miR3p. +lncRNA target 33270361 hsa-mir-2355 Tachycardia, Ventricular CONCLUSIONS: Silencing SOX2-OT alleviated cardiac dysfunction in rats by reducing the activation of NLRP3 inflammasomes via regulating miR3p. +lncRNA target 33269829 hsa-mir-34a Migraine Disorders OBJECTIVE: To investigate the effect of electroacupuncture(EA) on miR-34a-5p, silent mating type information regulation 2 homolog-1 (SIRT1) and nuclear factor-kappaB subunit p65 (NF-kappaB p65) in the trigeminal ganglion of rats with migraine, so as to explore the mechanisms of EA underlying prevention of migraine. CONCLUSION: In migraine rats, EA can inhibit miR-34a-5p expression in the trigeminal ganglion, increase SIRT1 expression, down-regulate IL-1beta/COX2 inflammation signals, reduce PGE2 synthesis, and thus redue CGRP released from the peripheral terminals, which may be one of the mechanisms of EA in preventing migraine. +other 33269809 hsa-mir-451 Burns OBJECTIVES: To investigate the role of miRNA-451 and to clarify the underlying mechanism of the burn process. +lncRNA target 33269380 hsa-mir-152 Carcinoma, Non-Small-Cell Lung And miR-152 targeted TNS1 to affect the progression of NSCLC. CONCLUSION: miR-152/TNS1 axis inhibits the progression of NSCLC by Akt/mTOR/RhoA pathway. +lncRNA target 33269379 hsa-mir-26b Adenocarcinoma of Lung Subsequently, we testified that DUXAP8 exerted its role in the progression and development of LUAD through targeting miR-26b-5p. In summary, our results elucidated that that DUXAP8 promoted tumor progression in LUAD by targeting miR-26b-5p, which provide a novel therapeutic target for diagnosis and therapy of LUAD. +other 33269007 hsa-mir-187 Carcinoma, Non-Small-Cell Lung Long Intergenic Non-Protein Coding RNA 01089 Weakens Tumor Proliferation, Migration, and Invasion by Sponging miR-3187-3p in Non-Small Cell Lung Can +other 33268996 hsa-mir-25 Stomach Neoplasms 3p, which directly interacted with GITR to regulate cisplatin resistance of gastric cancer. +genetics_knock down_promote 33268995 hsa-mir-223 Stomach Neoplasms The miR-223 knockdown in macrophages could reduce the effects of exosomes on GC cells. +target gene 33268993 hsa-mir-222 Prostatic Neoplasms Hepsin Promotes Epithelial-Mesenchymal Transition and Cell Invasion Through the miR-222/PPP2R2A/AKT Axis in Prostate Cancer. +circulation_biomarker_diagnosis_up 33268243 hsa-mir-29a Carcinoma, Hepatocellular PATIENTS AND METHODS Serum microRNA expression profiles (miRNA-29a, miRNA-200, miRNA-335 and miRNA-21) were analysed in 137 patients with HCC and liver cirrhosis and 49 healthy subjects (used as negative controls) using real-time quantitative reverse transcription polymerase chain reaction. RESULTS The expression levels of miRNA-21, miRNA-335 and miRNA-200 were significantly up-regulated, whereas those of miRNA-29a were remarkably down-regulated in patients with HCC compared with those in healthy subjects. +circulation_biomarker_diagnosis_up 33268243 hsa-mir-29a Hepatitis C PATIENTS AND METHODS Serum microRNA expression profiles (miRNA-29a, miRNA-200, miRNA-335 and miRNA-21) were analysed in 137 patients with HCC and liver cirrhosis and 49 healthy subjects (used as negative controls) using real-time quantitative reverse transcription polymerase chain reaction. RESULTS The expression levels of miRNA-21, miRNA-335 and miRNA-200 were significantly up-regulated, whereas those of miRNA-29a were remarkably down-regulated in patients with HCC compared with those in healthy subjects. +circulation_biomarker_diagnosis_up 33268243 hsa-mir-335 Hepatitis C PATIENTS AND METHODS Serum microRNA expression profiles (miRNA-29a, miRNA-200, miRNA-335 and miRNA-21) were analysed in 137 patients with HCC and liver cirrhosis and 49 healthy subjects (used as negative controls) using real-time quantitative reverse transcription polymerase chain reaction. RESULTS The expression levels of miRNA-21, miRNA-335 and miRNA-200 were significantly up-regulated, whereas those of miRNA-29a were remarkably down-regulated in patients with HCC compared with those in healthy subjects. +circulation_biomarker_diagnosis_ns 33268243 hsa-mir-200 Carcinoma, Hepatocellular PATIENTS AND METHODS Serum microRNA expression profiles (miRNA-29a, miRNA-200, miRNA-335 and miRNA-21) were analysed in 137 patients with HCC and liver cirrhosis and 49 healthy subjects (used as negative controls) using real-time quantitative reverse transcription polymerase chain reaction. +circulation_biomarker_diagnosis_up 33268243 hsa-mir-335 Carcinoma, Hepatocellular PATIENTS AND METHODS Serum microRNA expression profiles (miRNA-29a, miRNA-200, miRNA-335 and miRNA-21) were analysed in 137 patients with HCC and liver cirrhosis and 49 healthy subjects (used as negative controls) using real-time quantitative reverse transcription polymerase chain reaction. RESULTS The expression levels of miRNA-21, miRNA-335 and miRNA-200 were significantly up-regulated, whereas those of miRNA-29a were remarkably down-regulated in patients with HCC compared with those in healthy subjects. +circulation_biomarker_diagnosis_up 33268243 hsa-mir-21 Hepatitis C PATIENTS AND METHODS Serum microRNA expression profiles (miRNA-29a, miRNA-200, miRNA-335 and miRNA-21) were analysed in 137 patients with HCC and liver cirrhosis and 49 healthy subjects (used as negative controls) using real-time quantitative reverse transcription polymerase chain reaction. RESULTS The expression levels of miRNA-21, miRNA-335 and miRNA-200 were significantly up-regulated, whereas those of miRNA-29a were remarkably down-regulated in patients with HCC compared with those in healthy subjects. +circulation_biomarker_diagnosis_up 33268243 hsa-mir-21 Carcinoma, Hepatocellular PATIENTS AND METHODS Serum microRNA expression profiles (miRNA-29a, miRNA-200, miRNA-335 and miRNA-21) were analysed in 137 patients with HCC and liver cirrhosis and 49 healthy subjects (used as negative controls) using real-time quantitative reverse transcription polymerase chain reaction. RESULTS The expression levels of miRNA-21, miRNA-335 and miRNA-200 were significantly up-regulated, whereas those of miRNA-29a were remarkably down-regulated in patients with HCC compared with those in healthy subjects. +circulation_biomarker_diagnosis_ns 33268243 hsa-mir-200 Hepatitis C PATIENTS AND METHODS Serum microRNA expression profiles (miRNA-29a, miRNA-200, miRNA-335 and miRNA-21) were analysed in 137 patients with HCC and liver cirrhosis and 49 healthy subjects (used as negative controls) using real-time quantitative reverse transcription polymerase chain reaction. +lncRNA target 33268037 hsa-mir-142 Stomach Neoplasms In conclusion, our findings suggest that miR-142 plays a significant role in suppressing progression of GC by targeting LRP8, and miR-142 may be useful for the development of novel targeted therapies. +genetics_knock down_promote 33267766 hsa-mir-133b Osteosarcoma RESULTS: It was probed that after the suppression of autophagy-associated miRNAs by adriamycin and rapamycin, while most of the miRNAs were down-regulated in osteosarcoma cell lines, some miRNAs' expressions, such as miR-3141, miR-4296, miR-133b, and miR-720, were strikingly increased. CONCLUSION: Together, we propose that the expressions of miR-3141, miR-4296, miR-133b, and miR-720 might exacerbate the pathogenesis of osteosarcoma; therefore, the suppression of these miRNAs with the loss-offunction approaches could be an appropriate strategy that is worth testing in osteosarcoma. +genetics_knock down_promote 33267766 hsa-mir-4296 Osteosarcoma RESULTS: It was probed that after the suppression of autophagy-associated miRNAs by adriamycin and rapamycin, while most of the miRNAs were down-regulated in osteosarcoma cell lines, some miRNAs' expressions, such as miR-3141, miR-4296, miR-133b, and miR-720, were strikingly increased. CONCLUSION: Together, we propose that the expressions of miR-3141, miR-4296, miR-133b, and miR-720 might exacerbate the pathogenesis of osteosarcoma; therefore, the suppression of these miRNAs with the loss-offunction approaches could be an appropriate strategy that is worth testing in osteosarcoma. +genetics_knock down_promote 33267766 hsa-mir-141 Osteosarcoma RESULTS: It was probed that after the suppression of autophagy-associated miRNAs by adriamycin and rapamycin, while most of the miRNAs were down-regulated in osteosarcoma cell lines, some miRNAs' expressions, such as miR-3141, miR-4296, miR-133b, and miR-720, were strikingly increased. CONCLUSION: Together, we propose that the expressions of miR-3141, miR-4296, miR-133b, and miR-720 might exacerbate the pathogenesis of osteosarcoma; therefore, the suppression of these miRNAs with the loss-offunction approaches could be an appropriate strategy that is worth testing in osteosarcoma. +genetics_knock down_promote 33267766 hsa-mir-720 Osteosarcoma RESULTS: It was probed that after the suppression of autophagy-associated miRNAs by adriamycin and rapamycin, while most of the miRNAs were down-regulated in osteosarcoma cell lines, some miRNAs' expressions, such as miR-3141, miR-4296, miR-133b, and miR-720, were strikingly increased. CONCLUSION: Together, we propose that the expressions of miR-3141, miR-4296, miR-133b, and miR-720 might exacerbate the pathogenesis of osteosarcoma; therefore, the suppression of these miRNAs with the loss-offunction approaches could be an appropriate strategy that is worth testing in osteosarcoma. +genetics_overexpression_promote 33266425 hsa-mir-1 Lung Neoplasms By using a bioinformatics approach, we found that FAM83A overexpression in lung cancer may result from miR +circulation_biomarker_diagnosis_up 33264723 hsa-mir-126 Skin Diseases 5p can serve as potential serum biomarkers for SD. +circulation_biomarker_diagnosis_up 33264723 hsa-mir-16 Skin Diseases 5p can serve as potential serum biomarkers for SD. +exosome 33264631 hsa-mir-425 Lung Injury CONCLUSION: Our data supported that miR-425 in BMSCs-Exos inhibits HILI by targeting PTEN and upregulating the PI3K/AKT axis. +exosome 33264631 hsa-mir-425 Hyperoxia-Induced Lung Injury CONCLUSION: Our data supported that miR-425 in BMSCs-Exos inhibits HILI by targeting PTEN and upregulating the PI3K/AKT axis. +circRNA target 33264494 hsa-mir-1227 Osteosarcoma Thereafter, molecular techniques such as Western blot, qRT-PCR, RNA-binding protein immunoprecipitation and Dual-Luciferase reporter assays were implemented to investigate the role of circ-0000658/miR-1227/interferon regulatory factor-2 (IRF2) axis in OS. Conclusively, circ-0000658 modulates biological function of OS cells through the miR-1227/IRF2 axis. +genetics_overexpression_promote 33264420 hsa-mir-132 Carcinoma, Hepatocellular The conditioned medium of miRoverexpressing Th17 cells could increase the activation of the HSCs, which strongly promoted HCC cell migration and epithelial-mesenchymal transition (EMT). +lncRNA target 33264082 hsa-mir-452 Neuralgia Finally, through a rescue assay, we found that GAS5 ameliorated neuropathic pain in CCI rats by sponging miR +other 33264079 hsa-mir-126 Brain Ischemia Our results indicate that TFAP2A downregulates miR-126, and thereby upregulates PLK2 and activates the IkappaBalpha-NF-kappaB pathway, which increased neuronal injury following cerebral ischemia. +circulation_biomarker_diagnosis_ns 33263228 hsa-mir-26 Kidney Tubular Necrosis, Acute Specifically, miR3p, 192-5p, and 378a-3p with highly expressed levels in urine of rats with GEN-induced acute tubular injury were considered to have sensitivities comparable to clinical biomarkers, such as blood urea nitrogen, serum creatinine, and urinary kidney injury molecule protein. +other 33263223 hsa-mir-27a Coronary Artery Disease An increase in the expression levels of miR-27a and miR-329 may lead to the progression of atherosclerosis plaque by downregulating the expression of ABCA1 and ABCG1 genes. +other 33263223 hsa-mir-29 Coronary Artery Disease An increase in the expression levels of miR-27a and miR-329 may lead to the progression of atherosclerosis plaque by downregulating the expression of ABCA1 and ABCG1 genes. +circRNA target 33262952 hsa-mir-1265 Carcinoma, Hepatocellular In terms of mechanism, we demonstrated that circGSK3B acts as a miR-1265 sponge, positively regulates the target gene CAB39, and promotes the reprogramming of glutamine metabolism, thereby promoting the progression of HCC. +genetics_knock down_promote 33262837 hsa-mir-181a-2 Pulmonary Disease, Chronic Obstructive Overall, MEG3-knockdown suppressed CSE-induced apoptosis, inflammation and cytotoxicity in 16HBE cells by upregulating miR-181a +lncRNA target 33262831 hsa-mir-31 Lymphoma, Large B-Cell, Diffuse In conclusion, the present findings firstly demonstrated that UCA1 silencing restrained DLBCL cell proliferation and metastases viability by suppressing miR +genetics_knock down_suppress 33262825 hsa-mir-4636 Stomach Neoplasms Furthermore, miR-4636 overexpression significantly inhibited GC cell proliferation, migration and invasion, indicating the potential of miR-4636 as a therapeutic target for GC treatment. +transcription factor target 33262822 hsa-mir-219 Heart Defects, Congenital 5p may be a potential therapeutic target for cyanotic CHD therapy. +circulation_biomarker_diagnosis_up 33262815 hsa-mir-29 Diabetes Mellitus, Type 2 3p expression in the plasma of patients with T2DM was reduced, suggesting that upregulation of miR +circulation_biomarker_diagnosis_ns 33262812 hsa-mir-126 Pancreatitis These results demonstrated that the combined detection of serum IL-6 and hsa-miR +circulation_biomarker_diagnosis_ns 33262812 hsa-mir-548d Pancreatitis For this, serum pro-inflammatory cytokines [tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, IL-6, IL-8 and IL-10)] and miRNAs [Homo sapiens (hsa)-miR-548d-5p, hsa-miR +target gene 33262782 hsa-mir-665 Stomach Neoplasms CircRNA_100876 Is Upregulated in Gastric Cancer (GC) and Promotes the GC Cells' Growth, Migration and Invasion via miR-665/YAP1 Signaling. +genetics_overexpression_promote 33262657 hsa-mir-515 Retinoblastoma CONCLUSION: It could be concluded that overexpressed miR +genetics_knock down_promote 33262650 hsa-mir-383 Glioma 5p abolished the effects of TMPO-AS1 knockdown on glioma cells. +lncRNA target 33262626 hsa-mir-503 Norrie disease However, whether lncRNA-MIR503HG (miR-503 host gene) is co-transcribed with miR-503 and affects miR-503 splicing, thereby affecting its target gene Bcl-2 expression and cell mitochondrial apoptotic pathway in diabetic nephropathy (DN) is currently unknown. +lncRNA target 33262626 hsa-mir-503 Diabetic Nephropathies However, whether lncRNA-MIR503HG (miR-503 host gene) is co-transcribed with miR-503 and affects miR-503 splicing, thereby affecting its target gene Bcl-2 expression and cell mitochondrial apoptotic pathway in diabetic nephropathy (DN) is currently unknown. CONCLUSION: MIR503HG indirectly regulates Bcl-2 by promoting the co-transcription of miRNA-503 to participate high-glucose-induced proximal tubular cell apoptosis, providing a new target for diabetic nephropathy treatment. +other 33262617 hsa-mir-16-1 Tuberculosis 1-3p was significantly decreased (P=0.0032). +other 33262617 hsa-mir-23a Tuberculosis 1-3p was significantly decreased (P=0.0032). +other 33262617 hsa-mir-193a Tuberculosis 1-3p was significantly decreased (P=0.0032). +other 33262617 hsa-mir-183 Tuberculosis 1-3p was significantly decreased (P=0.0032). +other 33262617 hsa-mir-941 Tuberculosis 1-3p was significantly decreased (P=0.0032). +lncRNA target 33262606 hsa-mir-338 Osteosarcoma 3p/RAB14 axis and can serve as a possible therapeutic target for OS patients. +other 33262604 hsa-mir-194 Retinoblastoma 5p to regulate WEE1 expression. +genetics_overexpression_promote 33262598 hsa-mir-9 Ischemic Stroke Overexpression of SNHG7 or suppression of miR-9 decreased the relative activity of ROS and the MDA level as well as enhancing cell viability, and SNHG7 reduced apoptosis rate in OGD/R-induced PC12 cells (IS cells). The suppressive effects of SNHG7 on the relative activity of ROS, the MDA level and apoptosis rate as well as the promotion effect of SNHG7 on cell viability were reversed by miR-9 mimics or sh-SIRT1 in IS cells. +genetics_overexpression_suppress 33262524 hsa-mir-10a Leukemia, Myeloid, Acute We previously reported that the microRNA miR-10a is strongly overexpressed in some AML, and demonstrate here that it modulates several key members of the p53/Rb network, including p53 regulator MDM4, Rb regulator RB1CC1, p21 regulator TFAP2C, and p53 itself. +lncRNA target 33262463 hsa-mir-338 Breast Neoplasms Moreover, we demonstrate that miR-29b-2 directly targets VEGF-A while miR-338 directly targets NRP1, and show that regulation of miR-29b-2 and miR-338 mediates the ability of FOXO3a to suppress VEGF-A/NRP1 signaling and breast cancer metastasis. +lncRNA target 33262463 hsa-mir-29b-2 Breast Neoplasms Moreover, we demonstrate that miR-29b-2 directly targets VEGF-A while miR-338 directly targets NRP1, and show that regulation of miR-29b-2 and miR-338 mediates the ability of FOXO3a to suppress VEGF-A/NRP1 signaling and breast cancer metastasis. +other 33262439 hsa-mir-21 Reperfusion Injury, Renal Ischemia We investigated the effects of vitamin D3 (Vit D) and erythropoietin (EPO) on microRNA-21(miR-21) expression in renal IR. +other 33262327 hsa-mir-873 Autistic Disorder Autism-associated miR-873 regulates ARID1B, SHANK3 and NRXN2 involved in neurodevelopment. +other 33261889 hsa-mir-42-1 Coronary Artery Disease RESULTS: A scoring model based on the upregulation of miR-146a_1 and miR-342_1, along with a history of myocardial infarction and the chronic usage of antithrombotic drugs, was able to predict MI/death at the level of safety-related events (higher vs lower risk scores: sHR: 4.61, 95% CI: 1.57-13.57, and p = 0.005). +other 33261889 hsa-mir-145-1 Coronary Artery Disease Another prediction model based on the downregulation of miR-145_1, age, and a history of unstable angina was also able to predict revascularization at the level of effectiveness-related events (higher vs lower risk scores: sHR: 2.90, 95% CI: 1.49-5.66, and p = 0.002). +other 33261889 hsa-mir-146a-1 Coronary Artery Disease RESULTS: A scoring model based on the upregulation of miR-146a_1 and miR-342_1, along with a history of myocardial infarction and the chronic usage of antithrombotic drugs, was able to predict MI/death at the level of safety-related events (higher vs lower risk scores: sHR: 4.61, 95% CI: 1.57-13.57, and p = 0.005). +genetics_knock down_promote 33261854 hsa-mir-205 Keloid HOXA11-AS knockdown or miR +other 33261827 hsa-mir-221 Neurodegenerative Diseases Using cultured cells, co-transfection of canine SOD1 and up-regulated miRNA in DM-affected dogs demonstrated that miR-23a, miR-142 and miR-221 significantly increased the proportion of cells with mutant SOD1 aggregation. +other 33261827 hsa-mir-142 Neurodegenerative Diseases Using cultured cells, co-transfection of canine SOD1 and up-regulated miRNA in DM-affected dogs demonstrated that miR-23a, miR-142 and miR-221 significantly increased the proportion of cells with mutant SOD1 aggregation. +other 33261827 hsa-mir-23a Neurodegenerative Diseases Using cultured cells, co-transfection of canine SOD1 and up-regulated miRNA in DM-affected dogs demonstrated that miR-23a, miR-142 and miR-221 significantly increased the proportion of cells with mutant SOD1 aggregation. +genetics_overexpression_suppress 33261630 hsa-mir-29c Ovarian Neoplasms RESULTS: Both high expression of KIF4A and lower expression of miR-29c-3p could be used as biomarkers indicating poor prognosis in OC patients. In subsequent assays, the proliferation and migration of OC cells were inhibited by the overexpression of miR-29c-3p. +circulation_biomarker_prognosis_ns 33261029 hsa-mir-320e Lymphoma, Extranodal NK-T-Cell These studies show that serum levels of exosomal miR5p, miR-320e, and miR-4454 are increased in ENKTL patients with poor prognosis. +circulation_biomarker_prognosis_ns 33261029 hsa-mir-21 Lymphoma, Extranodal NK-T-Cell These studies show that serum levels of exosomal miR5p, miR-320e, and miR-4454 are increased in ENKTL patients with poor prognosis. +circulation_biomarker_prognosis_ns 33261029 hsa-mir-4454 Lymphoma, Extranodal NK-T-Cell These studies show that serum levels of exosomal miR5p, miR-320e, and miR-4454 are increased in ENKTL patients with poor prognosis. +other 33261009 hsa-mir-378a Burkitt Lymphoma MiR-378a-3p Is Critical for Burkitt Lymphoma Cell Growth. +genetics_knock down_promote 33260174 hsa-mir-210 Ovarian Neoplasms METHODS: Human ovarian cancer cell lines OVCAR3 and SKOV3 were cultured in vitro, and miR-210 over-expression and low-expression ovarian cancer cell models were established by cell transfection. +genetics_overexpression_promote 33260155 hsa-mir-1272 Glioma Moreover, overexpression of ADAM9 reversed the inhibitory effects of miR-1272 on glioma cell progression. +other 33260001 hsa-let-7d Infant, Small For Gestational Age Differential expression of two miRNA markers; hsa-miR-374a-5p (p = 0*0176) and hsa-let-7d-5p (p = 0*0036), were validated in an independent population of 95 women (SGA n = 12, Control n = 83). In the validation cohort, which was enriched for SGA cases, the ROC AUCs were 0*71 for hsa-miR-374a-5p, and 0*74 for hsa-let-7d-5p, and 0*77 for the two combined. +other 33260001 hsa-mir-374a Infant, Small For Gestational Age Differential expression of two miRNA markers; hsa-miR-374a-5p (p = 0*0176) and hsa-let-7d-5p (p = 0*0036), were validated in an independent population of 95 women (SGA n = 12, Control n = 83). In the validation cohort, which was enriched for SGA cases, the ROC AUCs were 0*71 for hsa-miR-374a-5p, and 0*74 for hsa-let-7d-5p, and 0*77 for the two combined. +genetics_knock down_suppress 33259864 hsa-mir-1299 Breast Neoplasms Furthermore, CCND1 was a target of miR-1299, and CCND1 overexpression could reverse the effect of miR-1299 mimic on BC cell progression. +other 33259780 hsa-mir-484 Pulmonary Fibrosis CONCLUSIONS: These findings indicate that miR-484 could be a novel diagnostic indicator for drug-induced pulmonary fibrosis. +other 33259730 hsa-mir-146a Breast Neoplasms Conclusion: miR-146a can enhance the sensitivity of breast cancer cells to PTX; the mechanism may be related to the downregulation of IRAK1. +genetics_overexpression_promote 33258403 hsa-mir-129 Arthritis, Rheumatoid Silencing lncRNA NEAT1 or overexpressing miR-129/miR-204 enhanced miR-129/miR-204 expression, but reduced the extent of ERK1/2 phosphorylation, proliferation of FLSs, and synovitis in RA. +genetics_overexpression_promote 33258403 hsa-mir-204 Arthritis, Rheumatoid Silencing lncRNA NEAT1 or overexpressing miR-129/miR-204 enhanced miR-129/miR-204 expression, but reduced the extent of ERK1/2 phosphorylation, proliferation of FLSs, and synovitis in RA. +lncRNA target 33258220 hsa-mir-525 Pneumonia, Mycoplasma 5p mediates the invasion of trophoblast cells by regulating HOXD10, which provides new therapeutic targets for PE treatment. +other 33258220 hsa-mir-525 Pre-Eclampsia METHODS: The expressions of miR5p and Homeobox D10 (HOXD10) in pre-eclampsia (PE) and normal placentas were detected. +genetics_knock down_promote 33258087 hsa-mir-24 Reperfusion Injury, Cerebral Ischemia miR-24 overexpression in HMC-EVs reduced I/R injury, while miR-24 knockdown in HMC-EVs impaired the protective roles of HMC-EVs in I/R injury. Taken together, HMC-EVs-carried miR-24 played protective roles in I/R injury, possibly by targeting AQP4 and activating the P38 MAPK/ERK1/2/P13K/AKT pathway. +lncRNA target 33257597 hsa-mir-29c Head and Neck Neoplasms Further, upregulated miR-29c-5p expression inhibited the proliferation of HNSCC cells in vivo and in vitro. +other 33257506 hsa-mir-149 Colorectal Neoplasms Circular RNA 100146 Promotes Colorectal Cancer Progression by the MicroRNA 149/HMGA2 Axis. +exosome 33257140 hsa-mir-483 Biliary Tract Neoplasms CONCLUSION The expression of exosomal mir +exosome 33257140 hsa-mir-126 Biliary Tract Neoplasms CONCLUSION The expression of exosomal mir +other 33257015 hsa-mir-21 Ovarian Neoplasms Candidate RNA biomarkers that were more abundant in biofluids of ovarian cancer patients compared to controls in at least two independent studies include miR-21, the miR-200 family, miR-205, miR-10a and miR-346. +other 33257015 hsa-mir-346 Ovarian Neoplasms Candidate RNA biomarkers that were more abundant in biofluids of ovarian cancer patients compared to controls in at least two independent studies include miR-21, the miR-200 family, miR-205, miR-10a and miR-346. +other 33257015 hsa-mir-10a Ovarian Neoplasms Candidate RNA biomarkers that were more abundant in biofluids of ovarian cancer patients compared to controls in at least two independent studies include miR-21, the miR-200 family, miR-205, miR-10a and miR-346. +other 33257015 hsa-mir-205 Ovarian Neoplasms Candidate RNA biomarkers that were more abundant in biofluids of ovarian cancer patients compared to controls in at least two independent studies include miR-21, the miR-200 family, miR-205, miR-10a and miR-346. +other 33256846 hsa-mir-125a Spondylocheirodysplasia, Ehlers-Danlos Syndrome-Like MicroRNA sequencing found 81 microRNAs significantly altered in DPSCS-sEV, with miR-125a-3p showing a 12-fold upregulation. +genetics_GWAS 33256802 hsa-mir-192 Carcinoma, Hepatocellular 5p loss enhanced glycolysis and over produced lactate might further increase HCC malignant features via interacting with environmental non-tumor cells. +genetics_GWAS 33256802 hsa-mir-192 Hyperglycemia 5p loss enhanced glycolysis and over produced lactate might further increase HCC malignant features via interacting with environmental non-tumor cells. +other 33256799 hsa-mir-144 Carcinoma, Renal Cell RESULTS: circ_001287 and CEP55 were highly expressed while miR-144 was decreased in RCC tissues and cell lines. +lncRNA target 33256566 hsa-mir-126 Breast Neoplasms 5p can inhibit the migration of the breast cancer MCF7 cell line, which may involve its direct targeting of the 3'UTR of CNOT7. +genetics_overexpression_promote 33256380 hsa-mir-155 Multiple Myeloma MiR-155 overexpression also re-sensitized drug-resistant myeloma cells to bortezomib leading to cell death through targeting TNFAIP8, a negative mediator of apoptosis in vitro and in vivo. +transcription factor target 33256301 hsa-mir-146a Esophageal Squamous Cell Carcinoma MiR-146a may mediate the malignant biological behavior of esophageal cancer cells through the regulation of IRAK1. +other 33256278 hsa-mir-100 Carcinoma, Hepatocellular Conclusion: The level of miR-100 expression in hepatocellular carcinoma cells is low, so it is closely related to the invasion and metastasis and affects the prognostic survival of hepatocellular carcinoma patients. +transcription factor target 33255991 hsa-mir-375 Breast Neoplasms CONCLUSION: This two-phase study demonstrates that hsa-miR-375/RASD1 signaling is able to predict local control in early breast cancer patients, which-to our knowledge-is the first clinical report on a miR combined with one of its downstream target proteins predicting LC in breast cancer. +genetics_overexpression_promote 33255928 hsa-mir-215 Colorectal Neoplasms Results: Overexpression of miR +lncRNA target 33255413 hsa-mir-451a esophagus adenocarcinoma Inhibition of miR-451a in the radiation resistant OAC cell line OE19 increased radiosensitivity (Survival Fraction 73% vs. +transcription factor target 33255217 hsa-mir-34 Triple Negative Breast Neoplasms Studies on the activity of the ternary HA/PLI/miRNA-34 nanopolyplexes towards TNBC cell line MDA-MB-231 were conducted. The results suggest that the P5, with a ratio PLI/Ha of 0.05, was the most promising for the delivery of miR-34a into TNBC cells; the P5 nanocapsules were able to reduce Bcl-2 expression at a protein level, and had an effect in the overall cell viability after 24 h treatment. +transcription factor target 33255217 hsa-mir-34a Triple Negative Breast Neoplasms Studies on the activity of the ternary HA/PLI/miRNA-34 nanopolyplexes towards TNBC cell line MDA-MB-231 were conducted. The results suggest that the P5, with a ratio PLI/Ha of 0.05, was the most promising for the delivery of miR-34a into TNBC cells; the P5 nanocapsules were able to reduce Bcl-2 expression at a protein level, and had an effect in the overall cell viability after 24 h treatment. +other 33254423 hsa-mir-182 Chemical and Drug Induced Liver Injury These results show for the fi rst time that miR5p/TLR4 axis involved in CAPE's protection against CdCl(2)-induced hepatotoxicity, and may provide novel insights into the treatment of cadmium-related diseases. +genetics_knock down_suppress 33254297 hsa-mir-107 Squamous Cell Carcinoma of Head and Neck Result:The expression of miR-107 in laryngeal cancer tissues was significantly lower than that in adjacent normal tissues, while the expression of CACNA2D1 was just the opposite, the difference was statistically significant P<0.05; the expression of alpha2delta1 in laryngeal cancer tissues is significantly higher than in normal tissuesP<0.05; dual-luciferase reporter experiments confirmed that miR-107 binds to the 3'-UTR 202-209, 902-908 of the CACNA2D1 mRNA, thereby inhibiting the expression of CACNA2D1 and its biological effects; cell experiments showed that the proliferation, invasion, and clone formation of laryngeal cancer cells were significantly reduced after miR-107 overexpression P<0.05, and the cell proliferation, clone formation, and invasion were significantly enhanced after miR-107 was knocked down P<0.05 . +lncRNA target 33254176 hsa-mir-6838 Stomach Neoplasms GPRIN3 upregulation reversed the suppression of miR +circulation_biomarker_diagnosis_ns 33253979 hsa-mir-223 Lung Neoplasms Based on the criteria of >/=3 independent studies and a sensitivity and specificity of >0.8 we found blood-borne miR-20a, miR-10b, miR-150, and miR-223 to be excellent diagnostic biomarkers for non-small cell LC whereas miR-205 is specific for squamous cell carcinoma. +circulation_biomarker_diagnosis_ns 33253979 hsa-mir-20a Lung Neoplasms Based on the criteria of >/=3 independent studies and a sensitivity and specificity of >0.8 we found blood-borne miR-20a, miR-10b, miR-150, and miR-223 to be excellent diagnostic biomarkers for non-small cell LC whereas miR-205 is specific for squamous cell carcinoma. +circulation_biomarker_diagnosis_ns 33253979 hsa-mir-205 Lung Neoplasms Based on the criteria of >/=3 independent studies and a sensitivity and specificity of >0.8 we found blood-borne miR-20a, miR-10b, miR-150, and miR-223 to be excellent diagnostic biomarkers for non-small cell LC whereas miR-205 is specific for squamous cell carcinoma. +circulation_biomarker_diagnosis_ns 33253979 hsa-mir-10b Lung Neoplasms Based on the criteria of >/=3 independent studies and a sensitivity and specificity of >0.8 we found blood-borne miR-20a, miR-10b, miR-150, and miR-223 to be excellent diagnostic biomarkers for non-small cell LC whereas miR-205 is specific for squamous cell carcinoma. +circulation_biomarker_diagnosis_ns 33253979 hsa-mir-150 Lung Neoplasms Based on the criteria of >/=3 independent studies and a sensitivity and specificity of >0.8 we found blood-borne miR-20a, miR-10b, miR-150, and miR-223 to be excellent diagnostic biomarkers for non-small cell LC whereas miR-205 is specific for squamous cell carcinoma. +transcription factor target 33253931 hsa-mir-29a Osteoporosis Our studies provide a potential rationale for co-administration of PTH1-34 and miR3p inhibitors, to boost bone formation in severely affected osteoporosis patients, particularly in the cortical compartment. +transcription factor target 33253931 hsa-mir-29 Osteoporosis Our studies provide a potential rationale for co-administration of PTH1-34 and miR3p inhibitors, to boost bone formation in severely affected osteoporosis patients, particularly in the cortical compartment. +circulation_biomarker_diagnosis_up 33253792 hsa-mir-744 ST Elevation Myocardial Infarction CONCLUSION A set of circulating microRNAs (miR +circulation_biomarker_diagnosis_up 33253792 hsa-mir-30 ST Elevation Myocardial Infarction CONCLUSION A set of circulating microRNAs (miR +circulation_biomarker_diagnosis_up 33253792 hsa-mir-24 ST Elevation Myocardial Infarction CONCLUSION A set of circulating microRNAs (miR +exosome 33253716 hsa-mir-195 Neuroblastoma An inverse correlation of NLRX1 with miR-195 expression in EV-A71-infected SH-SY5Y cells was found. +lncRNA target 33253710 hsa-mir-92a Neointimal Hyperplasia Furthermore, AAV6 mediated miR-92a suppression gene therapy effectively resulted in decreased EndMT and less neointimal formation in vein grafts in vivo. +other 33253708 hsa-mir-21 Eye Infections, Fungal Thus, this work further reveals the biological role of miR-21 in fungal keratitis. +genetics_overexpression_promote 33253708 hsa-mir-21 Thinness Smad7 up-regulation repressed Th17 differentiation and enhanced Treg differentiation, which was abolished by miR-21 overexpression. +other 33253679 hsa-mir-29b Multiple Myeloma NEAT1/miR-29b-3p/Sp1 feedback loop enhanced the tolerance of MM cells to bortezomib. +genetics_GWAS 33253517 hsa-mir-129-2 Pancreatic Carcinoma 2), 6 DmRNAsandDMsandMethyCor database entries (MAPK8IP2, CPE, DPP6, MSI1, IL20RB and S100A2), and FMN2 gene from differential expressed mRNAs and differential single-nucleotide polymorphism (DmRNAsandDSNPs) database. +genetics_GWAS 33253517 hsa-mir-1251 Pancreatic Carcinoma 2), 6 DmRNAsandDMsandMethyCor database entries (MAPK8IP2, CPE, DPP6, MSI1, IL20RB and S100A2), and FMN2 gene from differential expressed mRNAs and differential single-nucleotide polymorphism (DmRNAsandDSNPs) database. +genetics_GWAS 33253517 hsa-mir-1179 Pancreatic Carcinoma 2), 6 DmRNAsandDMsandMethyCor database entries (MAPK8IP2, CPE, DPP6, MSI1, IL20RB and S100A2), and FMN2 gene from differential expressed mRNAs and differential single-nucleotide polymorphism (DmRNAsandDSNPs) database. +genetics_GWAS 33253517 hsa-mir-1224 Pancreatic Carcinoma 2), 6 DmRNAsandDMsandMethyCor database entries (MAPK8IP2, CPE, DPP6, MSI1, IL20RB and S100A2), and FMN2 gene from differential expressed mRNAs and differential single-nucleotide polymorphism (DmRNAsandDSNPs) database. +genetics_GWAS 33253517 hsa-mir-129-1 Pancreatic Carcinoma 2), 6 DmRNAsandDMsandMethyCor database entries (MAPK8IP2, CPE, DPP6, MSI1, IL20RB and S100A2), and FMN2 gene from differential expressed mRNAs and differential single-nucleotide polymorphism (DmRNAsandDSNPs) database. +transcription factor target 33252886 hsa-mir-22 Cardiomegaly In this study, we examined the impact of miRNA-22 in obesogenic diet-induced cardiovascular and metabolic disorders in females. In addition, our findings suggest miRNA-22 as a potential therapeutic target to treat obesity-related metabolic disorders in females. +transcription factor target 33252886 hsa-mir-22 Metabolic Diseases In this study, we examined the impact of miRNA-22 in obesogenic diet-induced cardiovascular and metabolic disorders in females. In addition, our findings suggest miRNA-22 as a potential therapeutic target to treat obesity-related metabolic disorders in females. +genetics_overexpression_promote 33252475 hsa-mir-181b Glioma Besides, miR-181b-5p restoration reversed the effects of circEZH2 overexpression to repress the malignant behaviors of glioma cells. +lncRNA target 33252198 hsa-mir-345 Breast Neoplasms In conclusion, lncRNA RACGAP1P promotes breast cancer invasion and metastasis via miR5p/RACGAP1 pathway-mediated mitochondrial fission. +lncRNA target 33251982 hsa-mir-518a Triple Negative Breast Neoplasms The expression of miR-518a-3p was dysregulated in TNBC cells. +circulation_biomarker_prognosis_ns 33251978 hsa-mir-185 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: Collectively, our findings have demonstrated that serum miR-185 might serve as a promising and robust biomarker for the early detection and prognosis prediction of NSCLC. +lncRNA target 33251678 hsa-mir-20b Carcinoma, Hepatocellular miR-320b inhibition also attenuated IR treatment-induced DNA damage to HCC cells; more importantly, RAD21 silencing significantly attenuated the effects of miR-320b inhibition on IR treatment-induced DNA damage, suggesting that miR-320b plays a role through targeting RAD21. +other 33251388 hsa-mir-29 Severe Acute Respiratory Syndrome MiR-29 family had the most binding sites (11 sites) on the SARS-CoV-2 genome. +target gene 33251387 hsa-mir-7 Lung Neoplasms inhibition of OGT by miR-7-5p decreased the growth and cancer metabolism of lung cancer. +genetics_GWAS 33251333 hsa-mir-21 Carcinoma, Non-Small-Cell Lung NSCLC cell lines were used to determine the effects of miR-21 knockdown on cell viability, cell cycle distribution, and p53 expression. +circulation_biomarker_diagnosis_ns 33251277 hsa-mir-1275 Epilepsy Results show that hsa-miR-1275 in serums of EUE were increased significantly, but in cerebrospinal fluid, the miRNA was decreased. Taken together, hsa-miR-1275 might represent a novel biomarker targeting MECP2 for human EUE. +lncRNA target 33251211 hsa-mir-204 Ovarian Diseases In a previous study, we found using high throughput sequencing that miR-204 is highly expressed in chicken atrophic ovaries. Collectively, our results indicate that miR-204 is highly expressed in chicken atrophic ovaries, which promotes GC apoptosis via repressing FOXK2 through the PI3K/AKT/mTOR pathway and inhibits autophagy by impeding the TRPM3/AMPK/ULK pathway. +other 33251198 hsa-mir-342 Fibrosis, Renal Various bioinformatic analyses revealed miR5p as a strong candidate regulator in RF. +target gene 33251130 hsa-mir-29c Meningioma Long Non-Coding RNA MEG3 Modifies Cell-Cycle, Migration, Invasion, and Proliferation Through AKAP12 by Sponging miR-29c in Meningioma Cells. +lncRNA target 33251119 hsa-mir-21 Glioma In this review, we gathered the existent data on miRNA-21 and gliomas, in terms of its expression levels, association with grade and prognosis, the pathways it involves and its targets in glioma, and finally how it leads to treatment resistance. +lncRNA target 33251049 hsa-mir-149 Colorectal Neoplasms 5p-mutant p53 feedback loop in oxaliplatin resistance of CRC, and they provide potential therapeutic targets for tumor chemoresistance. +lncRNA target 33251049 hsa-mir-150 Colorectal Neoplasms 5p-mutant p53 feedback loop in oxaliplatin resistance of CRC, and they provide potential therapeutic targets for tumor chemoresistance. +lncRNA target 33251046 hsa-mir-214 Aortic Valve Disease Taken together, our study showed that miR-214 inhibited aortic valve calcification via regulating osteogenic differentiation of VICs by directly targeting ATF4 and Sp7, indicating that miR-214 may act as a profound candidate of targeting therapy for CAVD. +other 33251045 hsa-mir-182 Osteosarcoma By sponging miR5p, SNHG10 can increase FZD3 expression and further maintain the activation of Wnt/beta-catenin singling pathway in OS cells. +other 33250960 hsa-mir-663a Pancreatic Neoplasms LncRNA C9orf139 can regulate the growth of pancreatic cancer by mediating the miR-663a/Sox12 axis. +genetics_knock down_suppress 33250684 hsa-mir-370 Myocardial Infarction This study demonstrated that circ_0010729 knockdown attenuated hypoxia-induced cardiomyocyte dysfunction via miR3p/TRAF6 axis, indicating a potential therapeutic target for myocardial infarction. +genetics_overexpression_promote 33250514 hsa-mir-551b Gallbladder Neoplasms Conjointly, our study suggests that overexpression of miR-551b-3p inhibited the EMT, migration, and invasion of GBCs by inhibiting the expression of H6PD, indicating that miR-551b-3p may serve as a potential target for future development of therapeutic strategies for GBC. +other 33250449 hsa-mir-29a Intrauterine Adhesion The presence of miR-29a in BMSCs-Exo may be an important factor in its resistance to fibrosis during endometrial repair of IUA. +other 33249973 hsa-mir-152 Carcinoma, Non-Small-Cell Lung The tolerance of NSCLC cells to NK cytotoxicity was negatively correlated with HLA-G and positively correlated with miR-152 expression. CONCLUSIONS: miR-152/HLA-G axis plays an oncogenic role in NSCLC by affecting cell proliferation and immune escape. +other 33249960 hsa-mir-1 Pars Planitis RESULTS This study showed that has-miR-145, has-miR-23b, has-miR-31 and has-miR-30b were significantly up-regulated in PP and down-regulated in SP endometrium samples. +circulation_biomarker_diagnosis_up 33249960 hsa-mir-23b Pars Planitis RESULTS This study showed that has-miR-145, has-miR-23b, has-miR-31 and has-miR-30b were significantly up-regulated in PP and down-regulated in SP endometrium samples. In serum samples, has-miR-145 and hsa-miR-23b were significantly down-regulated in both of PP and SP. +circulation_biomarker_diagnosis_up 33249960 hsa-mir-145 Spherocytosis, Hereditary RESULTS This study showed that has-miR-145, has-miR-23b, has-miR-31 and has-miR-30b were significantly up-regulated in PP and down-regulated in SP endometrium samples. In serum samples, has-miR-145 and hsa-miR-23b were significantly down-regulated in both of PP and SP. +circulation_biomarker_diagnosis_up 33249960 hsa-mir-23b Spherocytosis, Hereditary RESULTS This study showed that has-miR-145, has-miR-23b, has-miR-31 and has-miR-30b were significantly up-regulated in PP and down-regulated in SP endometrium samples. In serum samples, has-miR-145 and hsa-miR-23b were significantly down-regulated in both of PP and SP. +circulation_biomarker_diagnosis_up 33249960 hsa-mir-145 Pars Planitis RESULTS This study showed that has-miR-145, has-miR-23b, has-miR-31 and has-miR-30b were significantly up-regulated in PP and down-regulated in SP endometrium samples. In serum samples, has-miR-145 and hsa-miR-23b were significantly down-regulated in both of PP and SP. +other 33249960 hsa-mir-1 Spherocytosis, Hereditary RESULTS This study showed that has-miR-145, has-miR-23b, has-miR-31 and has-miR-30b were significantly up-regulated in PP and down-regulated in SP endometrium samples. +circulation_biomarker_prognosis_ns 33249927 hsa-mir-652 Acute Kidney Injury CONCLUSION: Serum and urinary miR +circulation_biomarker_prognosis_ns 33249927 hsa-mir-652 Heart Failure CONCLUSION: Serum and urinary miR +circRNA target 33249173 hsa-mir-21 Hypertension, Pulmonary Further assessment confirmed that circ_002723, circ_008021, circ_016925 and circ_020581 could have a potential ceRNA mechanism by sponging miR-23a or miR-21 to control downstream target gene and be involved in the pathophysiology of HPH. +circRNA target 33249173 hsa-mir-23a Hypertension, Pulmonary Further assessment confirmed that circ_002723, circ_008021, circ_016925 and circ_020581 could have a potential ceRNA mechanism by sponging miR-23a or miR-21 to control downstream target gene and be involved in the pathophysiology of HPH. +circulation_biomarker_diagnosis_down 33248692 hsa-mir-210 Otitis Media with Effusion In this study, the miR-210 level in serum and middle ear effusion of is significantly down-regulated in serum, middle ear effusion from OME patients (100 cases) compared with healthy volunteers (50 cases). +other 33248690 hsa-mir-145 Inflammation Hsa_circ_0006872 facilitated CSE-triggered apoptosis, inflammation and oxidative stress in HPMECs and BEAS-2B cells by regulating miR5p/NF-kappaB pathway. +genetics_overexpression_promote 33248413 hsa-mir-10b Triple Negative Breast Neoplasms PDCD4-AS1 or IQGAP2 overexpression effectively attenuated TNBC cell proliferation, migration and invasion, and increased the apoptosis rate, while this effect was abandoned in response to miR-10b-5p mimics transfection. +lncRNA target 33247967 hsa-mir-224 Melanoma LINC00665 promotes proliferative and migrating abilities of melanoma cells via targeting miR5p/VMA21 axis. +lncRNA target 33247856 hsa-mir-1343 Ovarian Neoplasms CONCLUSION: Our findings show that Novel long noncoding RNA LINC02323 promotes cell growth of ovarian cancer via TGF-beta receptor 1 by miR +genetics_knock down_promote 33247804 hsa-mir-122 Liver Injury 5p knockdown protects against APAP-mediated liver injury through up-regulating NDRG3. +lncRNA target 33247705 hsa-mir-196b Precursor Cell Lymphoblastic Leukemia-Lymphoma CONCLUSION: Our results suggest that miR-181a has an oncogenic, while miR-196b has a tumor suppressive role in pediatric ALL patients. +other 33247705 hsa-mir-181a Precursor Cell Lymphoblastic Leukemia-Lymphoma In this study, we aimed to evaluate the role of miR-181a and miR-196b in acute lymphoblastic leukemia (ALL) and correlate their expression with clinical and laboratory data. +other 33247701 hsa-mir-494 Stomach Neoplasms The purpose of this study was to address the effect of recombinant (rTGF-) on the anti-inflammatory activity of MDSCs in GC and its possible association with micro-RNA-494 expression in tumor tissue. Results also suggest a role for miRNA-494 in GC progression. +genetics_overexpression_promote 33247610 hsa-mir-139 Reflex Sympathetic Dystrophy Besides, Notch-1 overexpression reversed the effects of miR +transcription factor target 33247610 hsa-mir-139 Epilepsy Our results indicated that miR5p upregulation alleviated SREDs-induced oxidative stress and cell apoptosis via regulating the Notch pathway, which provides new insights into the role of miRNA in the occurrence and development of epilepsy. +genetics_knock down_suppress 33247530 hsa-mir-873 Laryngeal Neoplasms circ_0004507 knockdown or miR-873 overexpression inhibited cell proliferation, migration and invasion, and increased apoptosis and cisplatin sensitivity in laryngeal cancer cells. +genetics_overexpression_promote 33247214 hsa-mir-214 Mitochondrial Diseases Overexpression of miR-214 in vitro and in vivo decreased the expression of SIRT3, which resulted in extensive mitochondrial damages, thereby facilitating the onset of hypertrophy. +genetics_overexpression_promote 33247214 hsa-mir-214 Cardiomegaly Overexpression of miR-214 in vitro and in vivo decreased the expression of SIRT3, which resulted in extensive mitochondrial damages, thereby facilitating the onset of hypertrophy. +exosome 33246743 hsa-mir-23a Fibrosis, Atrial This study aimed to determine whether NRON promotes M2 macrophage polarization and alleviates atrial fibrosis through suppressing exosomal miR-23a derived from atrial myocytes. CONCLUSION: NRON promotes M2 macrophage polarization and alleviates atrial fibrosis through suppressing exosomal miR-23a derived from atrial myocytes. +genetics_knock down_promote 33246290 hsa-let-7b Breast Neoplasms The proliferation and migration ability of breast cancer cells were decreased significantly after SPINT1-AS1 knockdown, and it may inhibit its expression by sponging miR-let-7a/b/i-5p, thereby promoting breast cancer progression. CONCLUSIONS: SPINT1-AS1 can promote the proliferation and migration of breast cancer cells by regulating miR-let-7a/b/i-5p, suggesting that it may be an important regulator of breast cancer progression. +genetics_knock down_promote 33246290 hsa-let-7a Breast Neoplasms The proliferation and migration ability of breast cancer cells were decreased significantly after SPINT1-AS1 knockdown, and it may inhibit its expression by sponging miR-let-7a/b/i-5p, thereby promoting breast cancer progression. CONCLUSIONS: SPINT1-AS1 can promote the proliferation and migration of breast cancer cells by regulating miR-let-7a/b/i-5p, suggesting that it may be an important regulator of breast cancer progression. +genetics_knock down_promote 33246290 hsa-let-7i Breast Neoplasms The proliferation and migration ability of breast cancer cells were decreased significantly after SPINT1-AS1 knockdown, and it may inhibit its expression by sponging miR-let-7a/b/i-5p, thereby promoting breast cancer progression. CONCLUSIONS: SPINT1-AS1 can promote the proliferation and migration of breast cancer cells by regulating miR-let-7a/b/i-5p, suggesting that it may be an important regulator of breast cancer progression. +genetics_overexpression_promote 33246224 hsa-mir-133a Cardiomegaly Moreover, IKKepsilon overexpression impaired the protective function of miR-133a-3p in cardiomyocyte hypertrophy. +circulation_biomarker_diagnosis_ns 33246036 hsa-mir-140 Ischemic Stroke 5p mimic and TLR4 over-expression plasmid, neurological function score, TTC staining, TUNEL staining, as well as flow cytometry were carried out to evaluate the effects of miR +other 33246030 hsa-mir-137 Pituitary Neoplasms A combination of miR-137 and AZD9291 provided a potential treatment for PAs, especially for patients who show resistance to standard treatment. +transcription factor target 33245973 hsa-mir-10a Periapical Periodontitis miR-10a-5p showed the highest expression levels in AP. MiR-10a-5p was the most significantly up-regulated miRNA in AP and may play a critical role in suppressing inflammation and promoting healing. +lncRNA target 33245963 hsa-mir-450a-2 Stomach Neoplasms Mechanically, JHDM1D-AS1 promoted GC progression via the sponging of miR-450a +lncRNA target 33245963 hsa-mir-450a Stomach Neoplasms Mechanically, JHDM1D-AS1 promoted GC progression via the sponging of miR-450a +lncRNA target 33245749 hsa-mir-132 Heart Failure CDR132L, a specific antisense oligonucleotide, is a first-in-class miR-132 inhibitor that attenuates and even reverses HF in preclinical models. +other 33245732 hsa-mir-32 Breast Neoplasms Additionally, molecular docking approach was employed to investigate the regulatory role of hsa-miR3p assisted argonaute (AGO) protein of AURKA gene in BC. +other 33245684 hsa-mir-5196 Precursor Cell Lymphoblastic Leukemia-Lymphoma Results: In two independent cohorts, we found a significant association between rs10406069 in miR-5196 and the risk of developing hyperdiploid ALL. Conclusion: rs10406069 in miR-5196 may have a relevant role in hyperdiploid ALL risk. +other 33245416 hsa-mir-4463 Arteriosclerosis Obliterans MicroRNA 4463 (miR-4463) has been implicated in the development of arteriosclerosis obliterans, whereas the underlying mechanisms in VSMCs have not been fully addressed. +other 33245102 hsa-mir-130a Carcinoma, Hepatocellular Collectively, our findings provide evidence that FAM225A/miR-130a-5p/CCNG1 interaction network regulates the resistance of HCC cells to sorafenib treatment and could supply a possible strategy for restoring sorafenib sensitivity in HCC therapy. +transcription factor target 33245099 hsa-mir-211 Ovarian Neoplasms OC cells were treated with 0, 0.5, 1, and 2 mM LSZ, and quantitative real-time PCR was utilized to measure miR-211 levels in SK-OV-3 and OVCAR-3 cells with different treatment. Thus, we found that LSZ can inhibit the proliferation and migration of OC cells via regulating miR-211. +genetics_overexpression_promote 33244865 hsa-mir-140 Breast Neoplasms 3p and its overexpression partially inhibited the suppressive effect of miR +other 33244812 hsa-mir-193a Fatty Liver 5p and miR-193b-3p) were nominally associated with liver fibrosis (P < 0.05). +other 33244812 hsa-mir-187 Fatty Liver 5p and miR-193b-3p) were nominally associated with liver fibrosis (P < 0.05). +other 33244812 hsa-mir-193b Fatty Liver 5p and miR-193b-3p) were nominally associated with liver fibrosis (P < 0.05). +other 33244812 hsa-mir-122 Fatty Liver 5p and miR-193b-3p) were nominally associated with liver fibrosis (P < 0.05). +circulation_biomarker_diagnosis_ns 33244751 hsa-mir-223 Gastrointestinal Neoplasms CONCLUSION: Our meta-analysis showed the value of circulating miR-223 levels in the early diagnosis of diverse digestive system carcinomas. +lncRNA target 33244270 hsa-mir-582 Urinary Bladder Neoplasms TTK, the target gene of miR +target gene 33244266 hsa-mir-1224 Stomach Neoplasms LncRNA NEAT1 Promotes the Progression of Gastric Cancer Through Modifying the miR-1224-5p/RSF1 Signaling Axis. +target gene 33244241 hsa-mir-140 Colorectal Neoplasms miRNA-140 targeting TRAF6 affects the progression and growth of colorectal cancer, the mechanism could be miRNA-140 decreasing the TRAF6 expression effects on the NF-κB/c-jun signaling pathways. +genetics_knock down_promote 33244240 hsa-mir-876 Squamous Cell Carcinoma of Head and Neck 3p inhibition or MACC1 overexpression mitigated the inhibitory influences of LINC00519 depletion on cell proliferation, migration and invasion and neutralized the promoting actions of LINC00519 knockdown on cell apoptosis in TSCC. +genetics_overexpression_promote 33244226 hsa-mir-486 Pulmonary Disease, Chronic Obstructive 5p overexpression may enhance the TLR4-triggered inflammatory response in COPD patients by targeting HAT1. +epigenetics 33243974 hsa-mir-515 Esophageal Squamous Cell Carcinoma In addition, the data from whole-genome methylation sequencing and methylation-specific PCR indicated that the CpG island within miR +transcription factor target 33243745 hsa-mir-24 Kidney Failure, Chronic CONCLUSIONS: miR5p can inhibit the proliferation of rat chronic glomerulonephritis cells induced by LPS by inhibiting Syk/Ras/c-fos signaling pathway and may potentially serve as a diagnostic indicator and a therapeutic target for chronic glomerulonephritis. +lncRNA target 33243735 hsa-let-7c Carcinoma, Non-Small-Cell Lung CONCLUSIONS: The expression level of CDC25A is significantly increased in NSCLC with a negative correlation with Let-7c expression, which identifies CDC25A as a possible downstream target gene of Let-7c. +other 33242714 hsa-mir-196b Pancreatic Carcinoma Herein, we developed a dual-amplification-boosted, translational electrochemical biosensor for the detection of pancreatic cancer-associated microRNA, miR-196b. +lncRNA target 33242525 hsa-mir-502 Intracranial Aneurysm SIGNIFICANCE: Circ_0020397 played an important role in phenotypic modulation in IA by promoting VSMC viability via miR +other 33241864 hsa-mir-409 Myocardial Ischemia USP7 exacerbates myocardial ischemic injury by promoting inflammation and apoptosis of cardiomyocytes, and the up-regulation of its expression is partly caused by the down-regulation of miR5p expression. +transcription factor target 33241864 hsa-mir-409 Cardiomyopathies Conversely, the up-regulation of miR5p expression protected H9c2 cells from apoptosis and inhibited the release of cytokines and myocardial injury. +other 33241756 hsa-mir-17 Leukemia, Myeloid, Acute In all, our data suggest that HOTAIR may be subtype-specific in AML-M2 patients, also HOTAIR regulates AML differentiation by C/EBPBbeta/HOTAIR/miR5p/p21 pathway. +transcription factor target 33241567 hsa-mir-223 Selenium Deficiency To study the mechanism of aorta damage caused by Se deficiency, we constructed a Se deficiency porcine aorta model and found that Se deficiency can significantly inhibit miR-223, which downregulates the expression of nucleotide-binding oligomerization domain-like receptor family 3 (NLRP3). The results of this study show that Se deficiency in porcine arteries can induce inflammation through miR-223/NLRP3. +genetics_knock down_promote 33241432 hsa-mir-212 Parkinson Disease Our results demonstrated that NEAT1 knockdown suppressed PD progression through regulating the miR +transcription factor target 33240893 hsa-mir-129 Osteoporosis 5p inhibitor showed rescue effect on osteoporosis. +transcription factor target 33240879 hsa-mir-490 Tibial Meniscus Injuries Inhibition of miR5p alleviated cartilage injury in vivo as demonstrated using the destabilization of the medial meniscus (DMM) OA model. +transcription factor target 33240879 hsa-mir-490 myotonic dystrophy type 1 Inhibition of miR5p alleviated cartilage injury in vivo as demonstrated using the destabilization of the medial meniscus (DMM) OA model. +lncRNA target 33240879 hsa-mir-490 Cartilage Diseases 5p alleviated cartilage injury in vivo as demonstrated using the destabilization of the medial meniscus (DMM) OA model. +transcription factor target 33240879 hsa-mir-490 Osteoarthritis 5p facilitated hADSC chondrogenic differentiation and protected chondrocyte phenotype via the PITPNM1/PI3K/AKT axis, thus providing a novel stem cell potential therapeutic target for OA treatment. +exosome 33240878 hsa-mir-711 Alzheimer Disease In this study, we sought to characterize the alleviatory role of microRNA-711 (miR-711) encapsulated in microglia-derived extracellular vesicles (EVs) in a model of AD. The administration of microglia-derived EVs loaded with miR-711, which mediated the hyperphosphorylation of Tau protein in the Itpkb pathway, effectively alleviated neurodegenerative changes and cognitive dysfunction in AD. +exosome 33240878 hsa-mir-711 Nerve Degeneration In this study, we sought to characterize the alleviatory role of microRNA-711 (miR-711) encapsulated in microglia-derived extracellular vesicles (EVs) in a model of AD. The administration of microglia-derived EVs loaded with miR-711, which mediated the hyperphosphorylation of Tau protein in the Itpkb pathway, effectively alleviated neurodegenerative changes and cognitive dysfunction in AD. +lncRNA target 33240872 hsa-mir-23a Sexually Transmitted Diseases CGA regulated the p38 MAPK pathway through lncRNA GAS5/miR-23a/PTEN axis to promote autophagy in ST infection. CONCLUSION: CGA promotes autophagy and inhibits ST infection through the GAS5/miR-23a/PTEN axis and the p38 MAPK pathway. +lncRNA target 33240671 hsa-mir-26a Cardiomegaly MiR-26a-5p promoted LC3II and decreased p62 expression in PE-induced cardiac hypertrophy in the presence or absence of lysosomal inhibitor. +lncRNA target 33240426 hsa-mir-29b Endometrial Neoplasms Our previous study revealed that BCLassociated athanogene 3 (BAG3) may contribute to enhancing cell viability through downregulation of microRNA (miR)-29b in endometrial cancer cell lines. +genetics_overexpression_promote 33240410 hsa-mir-92b Prostatic Neoplasms The present study revealed that the overexpression of miR-92b-3p predicted poor prognosis in patients with PCa. +other 33240042 hsa-mir-184 Tuberous Sclerosis Moreover, hsa-miR-184 had the best diagnostic value for discriminating mTLE HS with 88.9% sensitivity and 83.3% specificity. +other 33240042 hsa-mir-184 familial temporal lobe epilepsy 3 Moreover, hsa-miR-184 had the best diagnostic value for discriminating mTLE HS with 88.9% sensitivity and 83.3% specificity. +target gene 33239918 hsa-mir-326 Prostatic Neoplasms Silencing circSLC19A1 Inhibits Prostate Cancer Cell Proliferation, Migration and Invasion Through Regulating miR-326/MAPK1 Axis. +lncRNA target 33239917 hsa-mir-92a Leukemia, Myeloid, Acute Interaction prediction websites revealed that circ_0002232 might affect the expression of PTEN and the process of AML through sponging miR-92a-3p. +transcription factor target 33239909 hsa-mir-485 Pain, Inflammatory 5p contributes to inflammatory pain through upregulating ASIC1 expression, implying a promising strategy for pain therapy. +lncRNA target 33239891 hsa-mir-33a Carcinoma, Non-Small-Cell Lung Circ_SATB2 attenuated Cela-mediated effects through targeting miR-33a-5p in NSCLC cells. CONCLUSION: Cela suppressed NSCLC development through regulating circ_SATB2/miR-33a-5p/E2F7 signaling cascade. +other 33239839 hsa-mir-210 Peripheral Vascular Diseases The expression of microRNA-210 in macrophages and myoblasts under ischemia might be indicative of a significant role in the recovery from ischemic lesions. +transcription factor target 33239653 hsa-mir-146a Hyperlipidemias We observed a dysregulation of miRNAs in HL tissues evidencing a discrete distribution in the heart-liver axis and three lipid metabolism-related miRNAs were identified: hsa-miR +transcription factor target 33239653 hsa-mir-21 Hyperlipidemias We observed a dysregulation of miRNAs in HL tissues evidencing a discrete distribution in the heart-liver axis and three lipid metabolism-related miRNAs were identified: hsa-miR +genetics_overexpression_promote 33239440 hsa-mir-345 Amyotrophic Lateral Sclerosis 5p was also overexpressed in patients compared with presymptomatic carriers, which supports the correlation of miR +other 33239422 hsa-mir-423 Asthma This study describes a novel role of PRMT1 as a coactivator for STAT1 or RUNX1, which is essential for the transcription of pri-let-7i and pri-miR-423 in epithelial cells and might be relevant to epithelium dysfunction in asthma. +other 33239422 hsa-let-7i Asthma This study describes a novel role of PRMT1 as a coactivator for STAT1 or RUNX1, which is essential for the transcription of pri-let-7i and pri-miR-423 in epithelial cells and might be relevant to epithelium dysfunction in asthma. +lncRNA target 33239403 hsa-mir-485 Dementia By contrast, NDAN individuals display low oxidative damage, which is associated with high levels of scavenging systems, possibly resulting from a lack of PGC1alpha miRNArelated inhibition. +lncRNA target 33239403 hsa-mir-485 Alzheimer Disease By contrast, NDAN individuals display low oxidative damage, which is associated with high levels of scavenging systems, possibly resulting from a lack of PGC1alpha miRNArelated inhibition. +lncRNA target 33239172 hsa-let-7b Huntington Disease However, the autophagy-associated target molecule of let7b miRNA remains unclear in HD. +transcription factor target 33239033 hsa-mir-155 Respiratory Syncytial Virus Infections CONCLUSION: Luteolin inhibits RSV replication by regulating the miR-155/SOCS1/STAT1 signaling pathway. +genetics_GWAS 33238873 hsa-mir-14a Breast Neoplasms This study aimed at clarifying the association of mir14a polymorphisms with breast cancer. +lncRNA target 33238792 hsa-mir-21 Lung Injury CONCLUSION: Curcumin post-treatment can alleviate the lung injuries induced by limb ischaemia-reperfusion via downregulating the levels of miR-21 mRNA. +genetics_GWAS 33238591 hsa-mir-145 Urinary Bladder Neoplasms In this study we evaluated association of PD-L1 expression with other prognostic biomarkers, such as expression of miRNA-145 and miRNA-200a, FGFR3 gene expression, and mutation status in tissue specimens of the luminal subtype of newly diagnosed high and low grade NMIBC. +genetics_GWAS 33238591 hsa-mir-200a Urinary Bladder Neoplasms In this study we evaluated association of PD-L1 expression with other prognostic biomarkers, such as expression of miRNA-145 and miRNA-200a, FGFR3 gene expression, and mutation status in tissue specimens of the luminal subtype of newly diagnosed high and low grade NMIBC. +circulation_biomarker_diagnosis_up 33238281 hsa-mir-24 Inflammatory Bowel Diseases Expressions of PMS2L2 and miR-24 in plasma from UC patients and healthy controls were determined by RT-qPCR. CONCLUSION: PMS2L2 may downregulate miR-24 via methylation to suppress cell apoptosis in UC. +lncRNA target 33238267 hsa-mir-223 Enterocolitis, Necrotizing METHODS: Among the top-listed target miRNAs in our previous differential microarray analysis, miR-223 and miR-451a were quantified in a pilot validation case-controlled study (NEC vs. +lncRNA target 33238267 hsa-mir-451a Enterocolitis, Necrotizing METHODS: Among the top-listed target miRNAs in our previous differential microarray analysis, miR-223 and miR-451a were quantified in a pilot validation case-controlled study (NEC vs. +other 33238264 hsa-mir-143 Urinary Bladder Neoplasms 3p/COX-2 axis contributes to BLCA progression. +circulation_biomarker_diagnosis_up 33238217 hsa-mir-211 Spinal Cord Injuries 5p agomir and 4-PBA effectively attenuated neuron apoptosis and reversed the expressions of apoptosis, inflammation and endoplasmic reticulum stress-related molecules post SCI in rats. +genetics_overexpression_promote 33238205 hsa-mir-211 Hypertension, Pulmonary Further, injection of exosomes overexpressed with miR-211 demonstrated that exosomal miR-211 aggravated PH while inhibition of miR-211 attenuated PH in rats. +circulation_biomarker_diagnosis_ns 33238163 hsa-mir-23b Encephalomyelitis, Autoimmune, Experimental Pathologically, miR23b-BMSC transplantation delayed EAE progression, apparently by reducing the Th17/Treg cell ratio and inhibiting inflammatory cell infiltration across the blood-brain barrier, and thus slowing spinal cord demyelination. +other 33237828 hsa-mir-182 Endometriosis 5p to upregulate downstream genes such as CHL1 to promote the development of endometriosis. +genetics_overexpression_promote 33237626 hsa-mir-298 Lung Neoplasms Overall, these findings indicate that Linc00485 overexpression down-regulates miR-298, resulting in the up-regulation of c-Myc and thereby promoting the development of lung cancer. +other 33237453 hsa-mir-181a salivary gland adenoid cystic carcinoma miR-181a-5p was down-regulated in SACC-LM and correlated with up-regulated hsa_circRNA_001982. Moreover, the interaction of hsa_circRNA_001982/miR-181a-5p is closely related to the metastasis of SACC cells. +circulation_biomarker_diagnosis_ns 33237353 hsa-mir-195 Carcinoma, Pancreatic Ductal Importantly, the levels of EV miR-21 and miR-195 were higher in PDAC blood EV preparations than in healthy controls, albeit we found no difference compared to chronic pancreatitis (CP) samples. +circulation_biomarker_diagnosis_ns 33237353 hsa-mir-21 Carcinoma, Pancreatic Ductal Importantly, the levels of EV miR-21 and miR-195 were higher in PDAC blood EV preparations than in healthy controls, albeit we found no difference compared to chronic pancreatitis (CP) samples. +lncRNA target 33237328 hsa-let-7d Intrauterine Adhesion Therefore, our data reveal that HMGA2 promotes IUA formation and suggest that let-7d can depress HMGA2 and may be a clinical targeting strategy in IUA. +other 33237235 hsa-mir-221 Squamous Cell Carcinoma of Head and Neck Micro-RNA-221(miR-221) is one of oncogenic miRNAs that plays a vital role in the development and progression of oral cancers. +circulation_biomarker_diagnosis_ns 33237144 hsa-mir-150 Obesity 5p is not associated to obesity (p 0.84), triglycerides (p 0.57), total cholesterol (p 0.51), HDL-C (p 0.75), LDL-C (p 0.32), and fasting blood glucose (p 0.42). +genetics_overexpression_promote 33236530 hsa-mir-188 Gallbladder Neoplasms 5p promoted the proliferation, migration, and invasion of GBC cells, while its overexpression inhibited cell invasion and induced cell apoptosis, and arrested GBC growth in vivo. +circulation_biomarker_diagnosis_ns 33236445 hsa-mir-223 Non-alcoholic Fatty Liver Disease Finally, serum IL-6 and miR-223 levels were elevated and correlated with each other in NAFLD patients. +other 33236350 hsa-mir-637 Essential Hypertension Hyperexpression of hsa_circ_0105015 combined with hypoexpression of hsa-miR-637 indicates vascular inflammation or endothelial dysfunction and has potential as a biomarker for early diagnosis of EH. +lncRNA target 33236157 hsa-mir-204 Stomach Neoplasms The downregulated expression of SNHG4 decreased the effects of miR2045p inhibitor on promoting cell proliferation, migration, invasion and epithelialmesenchymal transition, but enhanced the inhibitory effect of miR2045p on GC cell apoptosis. +transcription factor target 33236144 hsa-mir-18a Melanoma miR18a5p triggered proliferation of melanoma cells and inhibited apoptosis and autophagy by directly targeting and inhibiting EPHA7 expression. +circulation_biomarker_diagnosis_ns 33236127 hsa-mir-10a Colorectal Neoplasms Reverse transcriptionquantitative PCR was performed using samples from patients with CRC, and demonstrated that the expression levels of miR10a were significantly lower in serum and cancer tissue samples from patients with CRC compared with in serum from healthy individuals and paired noncancerous tissues, respectively. +other 33235725 hsa-mir-210 Pancreatitis, Chronic 3p may be used as a non-invasive biomarker that can be used to distinguish between patients with PDAC and CP. +other 33235725 hsa-mir-210 Carcinoma, Pancreatic Ductal 3p may be used as a non-invasive biomarker that can be used to distinguish between patients with PDAC and CP. +other 33235699 hsa-mir-155 Tuberculosis, Pulmonary CONCLUSION: Our research suggested that miR-155 may be an efficiency biomarker for active PTB diagnosis and bacteria-loads evaluation. +target gene 33235626 hsa-mir-140 Breast Neoplasms Long non-coding RNA TMPO-AS1 promotes tumor progression via sponging miR-140-5p in breast cancer. +genetics_overexpression_suppress 33235611 hsa-mir-345 Diabetes, Gestational 3p overexpression exhibited a protective role in patients with GDM by inhibiting HTR8-/SVneo cell apoptosis, and promoting cell proliferation and migration via targeting BAK1. +lncRNA target 33235501 hsa-mir-26a Carcinoma, Renal Cell CONCLUSION: MiR-26a-5p presents low expression in RCC and promotes RCC cell apoptosis and prevents cells from proliferating and invading by targeting E2F7, which is a promising therapeutic target for RCC. +therapeutic target 33235500 hsa-mir-615 Prostatic Neoplasms Circ_0062020 suppressed the radiosensitivity by miR-615-5p/TRIP13 axis in PCa cells, which might provide insights into the radiotherapy for PCa. +genetics_overexpression_promote 33235495 hsa-mir-24 Squamous Cell Carcinoma of Head and Neck Cell proliferation assay showed that overexpression of IUR and p53 led to decreased proliferation rate of LSCC cells, while overexpression of miR-24 led to increased proliferation rate of LSCC cells. +other 33235469 hsa-mir-29b Urinary Bladder Neoplasms LncRNA HCP5 Promotes Cell Invasion and Migration by Sponging miR-29b-3p in Human Bladder Cancer. +target gene 33235467 hsa-mir-1224 Osteosarcoma MiR-1224-5p Activates Autophagy, Cell Invasion and Inhibits Epithelial-to-Mesenchymal Transition in Osteosarcoma Cells by Directly Targeting PLK1 Through PI3K/AKT/mTOR Signaling Pathway. +other 33235461 hsa-mir-378a Colorectal Neoplasms miR-378a-3p expression was decreased in CRC samples and negatively correlated with LINC00339 expression in tumors. CONCLUSION: Our findings demonstrate the regulatory role of the SP1/LINC00339/miR-378a-3p/MED19 axis in CRC tumorigenesis and provide novel insight into the molecular mechanism underlying CRC. +lncRNA target 33235271 hsa-mir-10a Uterine Cervical Neoplasms Taken altogether, miR-10a-5p in CAF-EVs promoted CSCC cell angiogenesis and tumorigenicity via activation of Hh signaling by inhibition of TBX5, providing insight into novel treatment based on miR-10a-5p against CSCC. +circulation_biomarker_diagnosis_ns 33235064 hsa-mir-384 Trigeminal Neuralgia 5p, and miR-384, were significantly higher than those of healthy controls, and the difference was statistically significant.This study preliminarily confirmed the changes of serum miRNA expression profile in TN patients. +circulation_biomarker_diagnosis_ns 33235064 hsa-mir-132 Trigeminal Neuralgia 5p, and miR-384, were significantly higher than those of healthy controls, and the difference was statistically significant.This study preliminarily confirmed the changes of serum miRNA expression profile in TN patients. +circulation_biomarker_diagnosis_ns 33235064 hsa-mir-146b Trigeminal Neuralgia 5p, and miR-384, were significantly higher than those of healthy controls, and the difference was statistically significant.This study preliminarily confirmed the changes of serum miRNA expression profile in TN patients. +circulation_biomarker_diagnosis_ns 33235064 hsa-mir-155 Trigeminal Neuralgia 5p, and miR-384, were significantly higher than those of healthy controls, and the difference was statistically significant.This study preliminarily confirmed the changes of serum miRNA expression profile in TN patients. +lncRNA target 33235025 hsa-mir-29a Cardiomyopathies Our study suggests that LE exerts cardioprotective effects against MF, possibly through the upregulation of miR-29a-3p. +lncRNA target 33235025 hsa-mir-29 Myocardial Infarction Our study suggests that LE exerts cardioprotective effects against MF, possibly through the upregulation of miR-29a-3p. +lncRNA target 33235025 hsa-mir-29 Cardiomyopathies Our study suggests that LE exerts cardioprotective effects against MF, possibly through the upregulation of miR-29a-3p. +lncRNA target 33235025 hsa-mir-29a Myocardial Infarction Our study suggests that LE exerts cardioprotective effects against MF, possibly through the upregulation of miR-29a-3p. +genetics_overexpression_suppress 33234729 hsa-mir-375 Alzheimer Disease OBJECTIVE: To study the effect of lncRNA WT1-AS on oxidative stress injury (OSI) and apoptosis of neurons in Alzheimer's disease (AD) and its specific mechanisms related to the microRNA-375 (miR-375)/SIX4 axis and WT1 expression. CONCLUSION: Overexpression of WT1-AS can inhibit the miR-375/SIX4 axis, OSI and neuronal apoptosis in AD by inhibiting WT1 expression. +circulation_biomarker_diagnosis_ns 33234723 hsa-mir-503 Colorectal Neoplasms 5p were found elevated in plasma from larger tumors (5 cm as the cutoff) in CRC patients, and the merged AUC in training and validation set was 0.896 and 0.881. +circulation_biomarker_diagnosis_ns 33234723 hsa-mir-29 Colorectal Neoplasms 5p were found elevated in plasma from larger tumors (5 cm as the cutoff) in CRC patients, and the merged AUC in training and validation set was 0.896 and 0.881. +circulation_biomarker_diagnosis_ns 33234723 hsa-mir-20b Colorectal Neoplasms 5p were found elevated in plasma from larger tumors (5 cm as the cutoff) in CRC patients, and the merged AUC in training and validation set was 0.896 and 0.881. +genetics_knock down_suppress 33234721 hsa-mir-140 Urinary Bladder Neoplasms 5p inhibition partially reversed the effects of LINC01140 knockdown on FGF9 protein levels, bladder cancer phenotype, and macrophage M2 polarization. +transcription factor target 33234216 hsa-mir-210 Cardiomyopathies CONCLUSION: miR-210 exhibits anti-apoptosis and anti-autophagy effects, which alleviate myocardial injury in response to hypoxia. +circulation_biomarker_diagnosis_up 33234202 hsa-mir-21 Instent Restenosis This study suggests that the increased expression of serum miR-21 is related to ISR after PCI, and miR-21 can be a new predictor of ISR. +other 33234142 hsa-mir-502 Carcinoma, Hepatocellular CONCLUSION: The novel signaling axis circSOD2/miR5p/DNMT3a/JAK2/STAT3/circSOD2 provides a better understanding of HCC tumorigenesis. +lncRNA target 33233986 hsa-mir-518a Carcinoma, Non-Small-Cell Lung Taken together, we suggested an essential role of LINC00461/miR-518a-3p/WDR1 axis in NSCLC, which could be used as a potential therapeutic target for NSCLC treatment. +circulation_biomarker_prognosis_ns 33233960 hsa-mir-219 Multiple Organ Failure The serum miR +other 33233354 hsa-mir-6724 Pulmonary Fibrosis 5p, leading to increased KLF10 expression, resulting in cell cycle arrest in curcumin-treated IPF fibroblasts. +other 33232872 hsa-mir-499 Heart Injuries Transfer of microRNA was not restricted to liver injury -miR-499 was released following cardiac injury and correlated with an increase in the kidney. +other 33232872 hsa-mir-499 Chemical and Drug Induced Liver Injury Transfer of microRNA was not restricted to liver injury -miR-499 was released following cardiac injury and correlated with an increase in the kidney. +circulation_biomarker_diagnosis_ns 33232730 hsa-mir-122 Breast Neoplasms The expression of miR-122 was assessed in the tumor tissue by quantitative PCR, and the VEGF level was determined in serum by ELISA. +transcription factor target 33232670 hsa-mir-165 Primary Myelofibrosis Here, we show that ARGONAUTE10 (AGO10), which sequesters miR165/166, promotes AM development through the miR165/166 target gene REVOLUTA. +lncRNA target 33232618 hsa-mir-4295 Carcinoma, Non-Small-Cell Lung Conclusion: Circ_0016760 served as a growth-promoting circRNA in NSCLC by facilitating cell proliferation and glycolysis by regulating the miR-4295/E2F3 axis, providing a novel potential target for NSCLC treatment. +genetics_knock down_suppress 33232284 hsa-mir-18b Esophageal Squamous Cell Carcinoma Furthermore, FBP1 was found to be directly targeted by miR-18b-5p in ESCC cells. In addition, miR-18b-5p inhibitor treatment obviously reversed the increased fatty acid metabolism induced by loss of FBP1 in ESCC cells. +lncRNA target 33231844 hsa-mir-193a Esophageal Squamous Cell Carcinoma Collectively, our current study identified a novel positive feedback regulation between miR-193a-3p and ALKBH5 in ESCC, which may be helpful to gain insight into ESCC pathogenesis and provide novel therapeutic target for ESCC. +transcription factor target 33231826 hsa-mir-28 Carcinoma, Non-Small-Cell Lung 5p, a suppressor of Wnt/beta-catenin pathway, was down-regulated, while miR +transcription factor target 33231826 hsa-mir-28 Bone Diseases 5p, a suppressor of Wnt/beta-catenin pathway, was down-regulated, while miR +transcription factor target 33231826 hsa-mir-574 Bone Diseases 5p, a suppressor of Wnt/beta-catenin pathway, was down-regulated, while miR +transcription factor target 33231826 hsa-mir-574 Carcinoma, Non-Small-Cell Lung 5p, a suppressor of Wnt/beta-catenin pathway, was down-regulated, while miR +transcription factor target 33231826 hsa-mir-423 Carcinoma, Non-Small-Cell Lung 5p, a suppressor of Wnt/beta-catenin pathway, was down-regulated, while miR +transcription factor target 33231826 hsa-mir-423 Bone Diseases 5p, a suppressor of Wnt/beta-catenin pathway, was down-regulated, while miR +lncRNA target 33231584 hsa-mir-10b Carcinoma, Hepatocellular We present a novel miRNA cocktail therapy by encapsulating miR-199a/b-3p mimics (miR199) and antimiR-10b (antimiR10b) into PCACP for eliminating HCC. Validated by qRT-PCR, immunoblotting and immunohistochemistry, compared with miR199 or antimiR10b delivered alone, miR-cocktail therapy substantially inhibits HCC cell proliferation and tumor growth by targeting mTOR, PAK4, RHOC and epithelial-mesenchymal transition (EMT) pathways both in vitro and in vivo (i.v. +lncRNA target 33231584 hsa-mir-199 Carcinoma, Hepatocellular We present a novel miRNA cocktail therapy by encapsulating miR-199a/b-3p mimics (miR199) and antimiR-10b (antimiR10b) into PCACP for eliminating HCC. Validated by qRT-PCR, immunoblotting and immunohistochemistry, compared with miR199 or antimiR10b delivered alone, miR-cocktail therapy substantially inhibits HCC cell proliferation and tumor growth by targeting mTOR, PAK4, RHOC and epithelial-mesenchymal transition (EMT) pathways both in vitro and in vivo (i.v. +lncRNA target 33231584 hsa-mir-199a Carcinoma, Hepatocellular We present a novel miRNA cocktail therapy by encapsulating miR-199a/b-3p mimics (miR199) and antimiR-10b (antimiR10b) into PCACP for eliminating HCC. Validated by qRT-PCR, immunoblotting and immunohistochemistry, compared with miR199 or antimiR10b delivered alone, miR-cocktail therapy substantially inhibits HCC cell proliferation and tumor growth by targeting mTOR, PAK4, RHOC and epithelial-mesenchymal transition (EMT) pathways both in vitro and in vivo (i.v. +lncRNA target 33231584 hsa-mir-199b Carcinoma, Hepatocellular We present a novel miRNA cocktail therapy by encapsulating miR-199a/b-3p mimics (miR199) and antimiR-10b (antimiR10b) into PCACP for eliminating HCC. Validated by qRT-PCR, immunoblotting and immunohistochemistry, compared with miR199 or antimiR10b delivered alone, miR-cocktail therapy substantially inhibits HCC cell proliferation and tumor growth by targeting mTOR, PAK4, RHOC and epithelial-mesenchymal transition (EMT) pathways both in vitro and in vivo (i.v. +other 33231565 hsa-mir-122 Osteoarthritis 5p. +other 33231565 hsa-mir-122 Aspermia We found that miRNA5p was upregulated in human spermatogonia from obstructive azoospermia (OA) patients compared with non-obstructive azoospermia (NOA). +other 33231565 hsa-mir-122 Noma 5p. +other 33231565 hsa-mir-122 Azoospermia, Nonobstructive We found that miRNA5p was upregulated in human spermatogonia from obstructive azoospermia (OA) patients compared with non-obstructive azoospermia (NOA). +other 33231563 hsa-mir-1 Urinary Bladder Neoplasms 5p/TNS1 axis regulates BCa progression. +lncRNA target 33231561 hsa-mir-532 Acute Kidney Injury 3p to be targeted by LINC00052 in AKI. +other 33231363 hsa-mir-542 Stomach Neoplasms 5p might involve in formononetin exhibits anticancer activity in GC cells. +lncRNA target 33231338 hsa-mir-518a Periodontitis Moreover, we identified HIF-1alpha acted as a direct target of miR-518a-5p in hPDLCs and LINC01126 promoted periodontitis pathogenesis by regulating the miR-518a-5p/HIF-1alpha/MAPK pathway. CONCLUSION: LINC01126 promotes periodontitis pathogenesis of hPDLCs via miR-518a-5p/HIF-1alpha/MAPK pathway, providing a possible clue for LINC01126-based periodontal therapeutic approaches. +lncRNA target 33231089 hsa-mir-1246 Colorectal Neoplasms This study also indicates that targeting miR-1246 or blocking its transport from CAFs to CRC cells might represent a novel therapeutic approach in CRC treatment. +other 33230823 hsa-mir-218 Uterine Diseases We found that miR-218 was differentially expressed in EECs under conditions of endometrial inflammation. +exosome 33230823 hsa-mir-218 Endometritis In addition, exosomal miR-218 may provide a valuable diagnostic marker for bovine endometritis. +lncRNA target 33230482 hsa-mir-150 Fibrosis, Renal based RNAi is as a potential novel therapeutic agent for tubulointerstitial fibrosis, suppressing the SOCS1/JAK/STAT pathway and reducing macrophage influx. +target gene 33230480 hsa-let-7i Esophageal Neoplasms MicroRNA let-7i Inhibits Histone Lysine Demethylase KDM5B to Halt Esophageal Cancer Progression. +other 33230478 hsa-mir-433 Urinary Bladder Neoplasms Circular RNA circRIMS1 Acts as a Sponge of miR-433-3p to Promote Bladder Cancer Progression by Regulating CCAR1 Expression. +transcription factor target 33230477 hsa-mir-221 Kidney Failure, Chronic miR-221 is a therapeutic target to address cardiac fibrosis originating from renal disease and other causes. +transcription factor target 33230477 hsa-mir-221 Cardiomyopathies miR-221 is a therapeutic target to address cardiac fibrosis originating from renal disease and other causes. +exosome 33230475 hsa-mir-26a Esophageal Neoplasms M2 Macrophage-Derived Exosomal lncRNA AFAP1-AS1 and MicroRNA-26a Affect Cell Migration and Metastasis in Esophageal Cancer. +other 33230465 hsa-mir-125b Reperfusion Injury, Cerebral Ischemia Consequently, these findings showed that the circUCK2/miR-125b-5p/GDF11 axis is an essential signaling pathway during ischemia stroke. +exosome 33230464 hsa-mir-7670 Hypoxia-Ischemia, Brain Taken together, our findings indicate that circSHOC2 in IPAS-EXOs suppressed neuronal apoptosis and ameliorated neuronal damage by regulating autophagy and acting on the miR3p/SIRT1 axis, which might contribute to a therapeutic strategy for ischemic stroke treatment. +lncRNA target 33230463 hsa-mir-205 Triple Negative Breast Neoplasms 5p targeted multiple genes required for the cell cycle and repressed Akt phosphorylation, which thus inhibited the proliferation of TNBC cells. +exosome 33230461 hsa-mir-675 Corneal dystrophy, epithelial basement membrane 3p increased PD-L1 expression to stimulate the immune escape in vitro and EV-encapsulated miR +exosome 33230460 hsa-mir-1 Substance Abuse, Intravenous Our in vivo experiments indicated that sub-endplate injection of MSC-exosomes can ameliorate IVDD; however, after miR5p levels were downregulated in MSC-exosomes, these protective effects were inhibited. +target gene 33230459 hsa-mir-187 Thyroid Neoplasms ATF2-Induced lncRNA GAS8-AS1 Promotes Autophagy of Thyroid Cancer Cells by Targeting the miR-187-3p/ATG5 and miR-1343-3p/ATG7 Axes. +other 33230458 hsa-mir-613 Adenocarcinoma of Lung 5p plays an oncogenic role in LUAD by promoting cell proliferation and acting as a key regulator of the positive feedback loop underlying the link between the NF-kappaB/RELA and AKT/MAPK pathways. +virus_miRNA 33230457 ebv-mir-BART22 Nasopharyngeal Carcinoma miR-4721, Induced by EBV-miR-BART22, Targets GSK3β to Enhance the Tumorigenic Capacity of NPC through the WNT/β-catenin Pathway +target gene 33230457 hsa-mir-4721 Nasopharyngeal Carcinoma miR-4721, Induced by EBV-miR-BART22, Targets GSK3β to Enhance the Tumorigenic Capacity of NPC through the WNT/β-catenin Pathway +other 33230456 hsa-mir-18a Pre-Eclampsia A lack of miR-18a, which results in the upregulation of Smad2(FL), contributes to the development of PE. +circulation_biomarker_diagnosis_up 33230454 hsa-mir-122 Pulmonary Disease, Chronic Obstructive We identified miR-122 and miR-30a as differentially expressed miRNAs in sputum and plasma of COPD patients in exacerbation-month12 group. +target gene 33230450 hsa-mir-146b Carcinoma, Non-Small-Cell Lung miR-146b-5p Enhances the Sensitivity of NSCLC to EGFR Tyrosine Kinase Inhibitors by Regulating the IRAK1/NF-κB Pathway. +circRNA target 33230448 hsa-mir-145 Carcinoma, Hepatocellular 5p/NRAS axis in HCC, which may represent a potential therapeutic target for HCC. +other 33230446 hsa-mir-1205 Carcinoma, Hepatocellular circFN1 Mediates Sorafenib Resistance of Hepatocellular Carcinoma Cells by Sponging miR-1205 and Regulating E2F1 Expression. +genetics_GWAS 33230439 hsa-mir-499 Glioma Previous studies of correlations of microRNA (miR)-499 rs3746444 and miR-196a-2 rs11614913 polymorphisms with glioma risk have yielded inconsistent results. Our results suggested that miR-499 rs3746444 and miR-196a-2 rs11614913 have crucial roles in glioma susceptibility. +genetics_GWAS 33230439 hsa-mir-196a-2 Glioma Previous studies of correlations of microRNA (miR)-499 rs3746444 and miR-196a-2 rs11614913 polymorphisms with glioma risk have yielded inconsistent results. Our results suggested that miR-499 rs3746444 and miR-196a-2 rs11614913 have crucial roles in glioma susceptibility. +target gene 33230437 hsa-mir-767 Thyroid Neoplasms LINC-PINT Suppresses the Aggressiveness of Thyroid Cancer by Downregulating miR-767-5p to Induce TET2 Expression. +other 33230436 hsa-mir-515 Stomach Neoplasms In summary, the present findings provide mechanistic insights into circCUL3/miR5p/STAT3/HK2 axis regulation on the GC Warburg effect, providing a novel possibility for an understanding of GC pathogenesis. +circRNA target 33230434 hsa-mir-665 Carcinoma, Hepatocellular circTMEM45A promotes HCC progression through the miR-665/IGF2 axis and may serve as a novel diagnostic marker and target for treatment of HCC patients. +lncRNA target 33230261 hsa-mir-10b Breast Neoplasms Here, we report that SPAG5 is a direct target of miR-10b-3p, and its aberrantly high expression associates with poor disease-free survival in two large cohorts of breast cancer patients. Collectively, our data uncover an oncogenic feedback loop, comprising miR-10b-3p, SPAG5, and YAP/TAZ/TEAD, which fuels the aberrant proliferation of breast cancer. +lncRNA target 33230258 hsa-mir-93 Carcinoma, Renal Cell 3p plays an oncogenic role in renal cell carcinoma (RCC) by enhancing RCC cell proliferation and suppressing apoptosis. +genetics_overexpression_promote 33230102 hsa-mir-143 Diabetic Nephropathies Moreover, to study the underlying mechanism of circ_DLGAP4 in regulating DKD, bioinformatics method was consulted and miR-143 was predicted as its target. Subsequently, in vivo assays were performed and it was proved that overexpression of circ_DLGAP4 markedly promoted DKD progression in vivo via modulating miR-143/ERBB3/NF-kappaB/MMP-2. +transcription factor target 33229509 hsa-mir-34a Lymphopenia Furthermore, high levels of miR-34a-5p in naive CD4(+) T cells can in turn hinder Th1 cell polarization through the downregulation of CXCR3 leading to a less pronounced activation of cytotoxic T lymphocytes, natural killer, and natural killer T cells and possibly contributing to lymphocytopenia. +circulation_biomarker_diagnosis_ns 33229132 hsa-mir-148b Lung Neoplasms Further application of our approach to the clinical serum samples realized identification of dysregulated miR-21 and miR-148b in the lung cancer patients, showing a satisfactory agreement with the control assays performed with quantitative reverse transcription polymerase chain reaction (qRT-PCR). +circulation_biomarker_diagnosis_ns 33229132 hsa-mir-21 Lung Neoplasms Further application of our approach to the clinical serum samples realized identification of dysregulated miR-21 and miR-148b in the lung cancer patients, showing a satisfactory agreement with the control assays performed with quantitative reverse transcription polymerase chain reaction (qRT-PCR). +transcription factor target 33228829 hsa-mir-188 Colorectal Neoplasms Levels of miR-188 were upregulated in CRC tissues than in paired-normal tissues, as well as in various CRC cell lines. All findings indicate that miR-188 promotes CRC cell proliferation and invasion through targeting FOXL1/Wnt signaling and could be served as a potential therapeutic target for human CRC in the future. +other 33228759 hsa-mir-196a-2 Multiple Myeloma It can be concluded from the results that miR-1962a variant is effective in prognosis of the MM. +lncRNA target 33228711 hsa-mir-375 Melanoma RESULTS: In prostate carcinoma, transfection of antimiRs against miR-375 and miR-141 leads to tumor cell inhibition in 2D- and 3D-models. +lncRNA target 33228711 hsa-mir-141 Prostatic Neoplasms RESULTS: In prostate carcinoma, transfection of antimiRs against miR-375 and miR-141 leads to tumor cell inhibition in 2D- and 3D-models. +lncRNA target 33228711 hsa-mir-141 Melanoma RESULTS: In prostate carcinoma, transfection of antimiRs against miR-375 and miR-141 leads to tumor cell inhibition in 2D- and 3D-models. +other 33228711 hsa-mir-150 Prostatic Neoplasms In advanced melanoma and metastasis, we identify by a microRNA screen miR-150 as a particularly relevant oncomiR candidate, and validate this result in vitro and in vivo. +other 33228711 hsa-mir-150 Melanoma In advanced melanoma and metastasis, we identify by a microRNA screen miR-150 as a particularly relevant oncomiR candidate, and validate this result in vitro and in vivo. +lncRNA target 33228711 hsa-mir-375 Prostatic Neoplasms RESULTS: In prostate carcinoma, transfection of antimiRs against miR-375 and miR-141 leads to tumor cell inhibition in 2D- and 3D-models. +other 33228708 hsa-mir-129 Knee Injuries 3p and upregulated CPEB1 expressions were found in OA-treated chondrocytes. +other 33228708 hsa-mir-129 Osteoarthritis 3p and upregulated CPEB1 expressions were found in OA-treated chondrocytes. +genetics_knock down_promote 33228517 hsa-mir-29a Leukemia, Myeloid, Acute The role of XIST/miR-29a/MYC in cellular viability, apoptosis and drug resistance in AML was accessed via gain- and loss-of-function approaches. +other 33228451 hsa-mir-24 Pre-Eclampsia 5p, were significantly downregulated in patients with preeclampsia when compared to healthy pregnant women. +other 33228451 hsa-mir-28 Pre-Eclampsia 5p, were significantly downregulated in patients with preeclampsia when compared to healthy pregnant women. +other 33228451 hsa-mir-210 Pre-Eclampsia 5p, were significantly downregulated in patients with preeclampsia when compared to healthy pregnant women. +other 33228451 hsa-mir-29a Pre-Eclampsia 5p, were significantly downregulated in patients with preeclampsia when compared to healthy pregnant women. +other 33228451 hsa-mir-375 Pre-Eclampsia 5p, were significantly downregulated in patients with preeclampsia when compared to healthy pregnant women. +other 33228451 hsa-mir-218 Pre-Eclampsia 5p, were significantly downregulated in patients with preeclampsia when compared to healthy pregnant women. +other 33228451 hsa-mir-17 Pre-Eclampsia 5p, were significantly downregulated in patients with preeclampsia when compared to healthy pregnant women. +other 33228451 hsa-mir-197 Pre-Eclampsia 5p, were significantly downregulated in patients with preeclampsia when compared to healthy pregnant women. +other 33228451 hsa-mir-191 Pre-Eclampsia 5p, were significantly downregulated in patients with preeclampsia when compared to healthy pregnant women. +other 33228131 hsa-mir-146b Muscular Dystrophy, Facioscapulohumeral Validation studies in a separate group of patients with FSHD show consistent up-regulation of miR-100, miR-103, miR-146b, miR-29b, miR-34a, miR-454, miR-505, and miR-576. +other 33228131 hsa-mir-454 Muscular Dystrophy, Facioscapulohumeral Validation studies in a separate group of patients with FSHD show consistent up-regulation of miR-100, miR-103, miR-146b, miR-29b, miR-34a, miR-454, miR-505, and miR-576. +other 33228131 hsa-mir-103 Muscular Dystrophy, Facioscapulohumeral Validation studies in a separate group of patients with FSHD show consistent up-regulation of miR-100, miR-103, miR-146b, miR-29b, miR-34a, miR-454, miR-505, and miR-576. +other 33228131 hsa-mir-100 Muscular Dystrophy, Facioscapulohumeral Validation studies in a separate group of patients with FSHD show consistent up-regulation of miR-100, miR-103, miR-146b, miR-29b, miR-34a, miR-454, miR-505, and miR-576. +other 33228131 hsa-mir-505 Muscular Dystrophy, Facioscapulohumeral Validation studies in a separate group of patients with FSHD show consistent up-regulation of miR-100, miR-103, miR-146b, miR-29b, miR-34a, miR-454, miR-505, and miR-576. +genetics_GWAS 33227890 hsa-mir-486 Colorectal Neoplasms 5p) in CRC, CSCs, and metastasis, in order to reach a better understanding of the biomolecular and epigenetic mechanisms mir +lncRNA target 33227791 hsa-mir-1268a Thrombocythemia, Essential Among the 14 miRNAs, miR-1268a was downregulated in ET and showed an inverse correlation with its 8 putative target genes, including genes associated with thrombus formation and platelet activation (CDH6, EHD2, FUT1, KIF26A, LINC00346, PTPRN, SERF1A, and SLC6A9). These results suggest that the significant dysregulation of miR-1268a and its 8 target genes could be a unique expression of platelet mi-RNAs and miRNA/mRNA regulatory network in ET patients. +lncRNA target 33227790 hsa-mir-144 Diabetic Nephropathies CONCLUSION: CASC2 could alleviate the degree and process of apoptosis, inflammation, and fibrosis in diabetic nephropathic models by regulating the miR-144/SOCS2 axis. +target gene 33227047 hsa-mir-145 Prostatic Neoplasms CPEB1 orchestrates a fine-tuning of miR-145-5p tumor-suppressive activity on TWIST1 translation in prostate cancer cells. +other 33226531 hsa-mir-16 Infertility 5p) and levels of cell-free DNA (cfDNA) by real-time PCR in unexplained infertile patients. +other 33226531 hsa-mir-132 Infertility 5p) and levels of cell-free DNA (cfDNA) by real-time PCR in unexplained infertile patients. +other 33226531 hsa-mir-663b Infertility 5p) and levels of cell-free DNA (cfDNA) by real-time PCR in unexplained infertile patients. +other 33226531 hsa-mir-766 Infertility 5p) and levels of cell-free DNA (cfDNA) by real-time PCR in unexplained infertile patients. +other 33226531 hsa-mir-20a Infertility 5p) and levels of cell-free DNA (cfDNA) by real-time PCR in unexplained infertile patients. +lncRNA target 33226411 hsa-mir-214 Stomach Neoplasms Silencing of HEIH could suppress Gastric Carcinoma cell proliferation, migration and invasion by inhibiting miR3p. +circulation_biomarker_diagnosis_ns 33226155 hsa-mir-222 Obesity CONCLUSIONS: The HELs of circulating miR-122 conferred a 3.85-fold increase in the risk for obesity, whereas the HELs of both miR-122 and miR-222 conferred a 3.11-fold increase in the risk for obesity, which were also associated with higher anthropometric or biochemical parameters, such as BMI, WHR, fat percentage, serum high-density lipid levels, TGs, and MI, in Mayan children. +circulation_biomarker_diagnosis_ns 33226155 hsa-mir-122 Obesity CONCLUSIONS: The HELs of circulating miR-122 conferred a 3.85-fold increase in the risk for obesity, whereas the HELs of both miR-122 and miR-222 conferred a 3.11-fold increase in the risk for obesity, which were also associated with higher anthropometric or biochemical parameters, such as BMI, WHR, fat percentage, serum high-density lipid levels, TGs, and MI, in Mayan children. +lncRNA target 33225938 hsa-mir-125a Colorectal Neoplasms 5p/4EBP-1 axis and circ-ERBIN is a potential target for CRC treatment. +lncRNA target 33225938 hsa-mir-138 Colorectal Neoplasms 5p/4EBP-1 axis and circ-ERBIN is a potential target for CRC treatment. +transcription factor target 33225929 hsa-mir-126 Lung Injury Of which, inhibition of miR-155 in EMPs and miR-126 in PMPs alleviated the detrimental effects of EMPs and PMPs on vascular barrier function and lung injury. Mechanically, EMPs carrying miR-155 that down-regulates ZO-1 and claudin-5 and PMPs carrying miR-126 that up-regulates Cav-1, synergistically mediate pulmonary vascular leakage and lung injury after I/R. +transcription factor target 33225929 hsa-mir-155 Lung Injury Of which, inhibition of miR-155 in EMPs and miR-126 in PMPs alleviated the detrimental effects of EMPs and PMPs on vascular barrier function and lung injury. Mechanically, EMPs carrying miR-155 that down-regulates ZO-1 and claudin-5 and PMPs carrying miR-126 that up-regulates Cav-1, synergistically mediate pulmonary vascular leakage and lung injury after I/R. +other 33225922 hsa-mir-365-2 Papillomavirus Infections The top variants associated with cervical hrHPV persistence were in DAP (OR: 6.86, p = 7.15 x 10(- 8)), NR5A2 (OR: 3.65, p = 2.03 x 10(- 7)) and MIR365-2 (OR: 7.71, p = 2.63 x 10(- 7)) gene regions. +other 33225891 hsa-mir-195 Sepsis CONCLUSION: In summary, LUADT1 may protect cardiac endothelial cells against apoptosis in sepsis by regulating the miR-195/Pim-1 axis. +other 33225676 hsa-mir-340 Carcinoma, Non-Small-Cell Lung 5p. +lncRNA target 33225581 hsa-mir-24 Osteosarcoma According to the above-mentioned results, we suggest that EWSAT1 acts as an oncogene and that EWSAT1/miR3p/ROCK1 axial could be a new target in the treatment of OS. +genetics_overexpression_promote 33225091 hsa-mir-130a Triple Negative Breast Neoplasms Moreover, following the miR-130a-3p overexpression, the proliferation, anchorage-independent growth, and migration of the TNBC cells were reduced. +other 33224883 hsa-mir-16 Breast Neoplasms Moreover, the predictor consisting of miR-125b, miR-29c, miR-16, miR-1260, and miR-451 was able to differentiate breast cancer patients from controls. +other 33224883 hsa-mir-125b Breast Neoplasms Moreover, the predictor consisting of miR-125b, miR-29c, miR-16, miR-1260, and miR-451 was able to differentiate breast cancer patients from controls. +other 33224883 hsa-mir-29c Breast Neoplasms Moreover, the predictor consisting of miR-125b, miR-29c, miR-16, miR-1260, and miR-451 was able to differentiate breast cancer patients from controls. +other 33224883 hsa-mir-451 Breast Neoplasms Moreover, the predictor consisting of miR-125b, miR-29c, miR-16, miR-1260, and miR-451 was able to differentiate breast cancer patients from controls. +other 33224883 hsa-mir-1260 Breast Neoplasms Moreover, the predictor consisting of miR-125b, miR-29c, miR-16, miR-1260, and miR-451 was able to differentiate breast cancer patients from controls. +target gene 33224874 hsa-mir-1260b Adenocarcinoma of Lung miR-1260b Activates Wnt Signaling by Targeting Secreted Frizzled-Related Protein 1 to Regulate Taxane Resistance in Lung Adenocarcinoma. +transcription factor target 33224526 hsa-mir-5195 Acute Coronary Syndrome Among the predicted miRNAs, hsa-miR-4770, hsa-miR-5195, and hsa-miR-6088 all possessed two target genes, which might be closely related to the development of ACS. +transcription factor target 33224526 hsa-mir-4770 Acute Coronary Syndrome Among the predicted miRNAs, hsa-miR-4770, hsa-miR-5195, and hsa-miR-6088 all possessed two target genes, which might be closely related to the development of ACS. +transcription factor target 33224526 hsa-mir-6088 Acute Coronary Syndrome Among the predicted miRNAs, hsa-miR-4770, hsa-miR-5195, and hsa-miR-6088 all possessed two target genes, which might be closely related to the development of ACS. +lncRNA target 33224342 hsa-mir-22 Osteoporosis CONCLUSIONS: Inhibition of miR-22 may be a potential target for treating osteoporosis clinically. +target gene 33224339 hsa-mir-610 Carcinoma, Hepatocellular MiRNA-610 acts as a tumour suppressor to depress the cisplatin resistance in hepatocellular carcinoma through targeted silencing of hepatoma-derived growth factor. +circulation_biomarker_diagnosis_up 33224315 hsa-mir-125b gastric adenocarcinoma RESULTS: The expression levels of miR-125b-5p and miR-196a-5p were upregulated in STAD serum, compared with the HCs, while miR +lncRNA target 33224312 hsa-mir-106a Carcinoma, Renal Cell Therefore, our data reveal that miR-106a-5p functions as a tumor suppressor by regulating VEGFA and ccRCC may be susceptible to miR-106a-5p therapy. +other 33224271 hsa-mir-127 Myocardial Infarction CONCLUSIONS: CALCA, CDK6, MDM2, NRXN1, SOCS3, VEGFA, SMAD4, NCAM1, and hsa-miR5p were thought to be potential diagnosis biomarkers for MI. +other 33224130 hsa-mir-155 Muscular Dystrophies In addition to miR-M4-5p (miR-155 homolog) and miR-M3-5p, we have recently found that miR-M2-5p possibly participate in inducing MD lymphomagenesis. +lncRNA target 33223850 hsa-mir-124 Adenocarcinoma of Lung 3p may inhibit the FGF2-EGFR pathway by targeting MGAT5 to decrease pemetrexed resistance in lung adenocarcinoma cells. +other 33223849 hsa-mir-29a Breast Neoplasms CircPVT1 Promoted the Progression of Breast Cancer by Regulating MiR-29a-3p-Mediated AGR2-HIF-1α Pathway. +lncRNA target 33223847 hsa-mir-1 Neuralgia CONCLUSION: While transfection with miR-1 mimics effective reduces Cx43 expression in vitro and restores miR-1 after CCI, we did neither observe altered levels of Cx43 protein level in nerves nor a beneficial effect on mechanical allodynia in vivo, most likely caused by insufficient Cx43 suppression. +lncRNA target 33223847 hsa-mir-1 Neurogenic Inflammation CONCLUSION: While transfection with miR-1 mimics effective reduces Cx43 expression in vitro and restores miR-1 after CCI, we did neither observe altered levels of Cx43 protein level in nerves nor a beneficial effect on mechanical allodynia in vivo, most likely caused by insufficient Cx43 suppression. +genetics_overexpression_promote 33223519 hsa-mir-185 Esophageal Neoplasms Overexpressing KLK5 alone promoted EC cell progression while up-regulating miR-185 reversed such effects on EC cells. +other 33223511 hsa-mir-222 Clear-cell metastatic renal cell carcinoma Our study revealed that the hsa_circ_0002286 / has-mir5p / TRIM2 axis played a critical role in the progression of ccRCC. +other 33223504 hsa-mir-29c Asthma Conclusively, lncRNA PVT1-miR-15a-5p/miR-29c-3p-PI3K-Akt-mTOR axis was implicated in ozone-induced asthma development by promoting ASMC proliferation and Th1/Th2 imbalance. +other 33223504 hsa-mir-15a Asthma Conclusively, lncRNA PVT1-miR-15a-5p/miR-29c-3p-PI3K-Akt-mTOR axis was implicated in ozone-induced asthma development by promoting ASMC proliferation and Th1/Th2 imbalance. +exosome 33223235 hsa-mir-136 Foot-and-Mouth Disease Also, microRNA (miRNA) differential analysis was performed in exosomes, which revealed that miRNA-136 was highly differentially expressed in exosomes and may be the key miRNA that inhibits the proliferation of FMDV. +other 33222929 hsa-mir-29a Intracranial Aneurysm VCAM1, TNF, CTSS, IL10, IL1B, IL6, and miR-29A/B/C might be the potential biomarkers for the formation and development of IA. +other 33222929 hsa-mir-29c Intracranial Aneurysm VCAM1, TNF, CTSS, IL10, IL1B, IL6, and miR-29A/B/C might be the potential biomarkers for the formation and development of IA. +other 33222929 hsa-mir-29b Intracranial Aneurysm VCAM1, TNF, CTSS, IL10, IL1B, IL6, and miR-29A/B/C might be the potential biomarkers for the formation and development of IA. +genetics_knock down_promote 33222607 hsa-mir-877 Carcinoma, Non-Small-Cell Lung In conclusion, miR-877 overexpression inhibited malignant biological behaviors of NSCLC cells by downregulating ACP5 and inactivating the PI3K/AKT pathway. +circRNA target 33221767 hsa-mir-638 Carcinoma, Non-Small-Cell Lung Present investigation discovered that hsa_circ_0001869 enhanced NSCLC progression via sponging miR-638 and promoting FOSL2 expression. +exosome 33221764 hsa-mir-544 Stomach Neoplasms These findings indicate that EV-mediated transfer of miR-544 decreases the PLZF expression in PM lesions, which suggests miR-544 could potentially serve as a diagnostic biomarker and therapeutic target for treatment of GC patients. +other 33221762 hsa-mir-181a Sarcopenia Correlation analysis showed that the expression levels of lncDLEU2, SEPP1, and miR-181a were closely associated with a high risk of sarcopenia. +genetics_GWAS 33221743 hsa-mir-34a Urinary Bladder Neoplasms In conclusion, DNMT3B silencing suppresses migration and invasion by epigenetically promoting miR-34a in bladder cancer. +transcription factor target 33221530 hsa-mir-155 Ventricular Premature Complexes RCN2/STAT3/miR5p feedback loop is important in VC and targeting each member of this feedback loop could potentially reverse high phosphate-induced VC. +lncRNA target 33221433 hsa-mir-5694 Breast Neoplasms, Basal Cell Additionally, microRNA-5694 (miR-5694) targeted and degraded AF9 messenger RNA (mRNA) in BLBC cells, further enhancing cell invasion and migration. +lncRNA target 33221374 hsa-mir-182 Atherosclerosis 5p and activating AKT pathway via improving VAV3 to promote AS progression. +lncRNA target 33221374 hsa-mir-182 Vascular Diseases 5p and activating AKT pathway via improving VAV3 to promote AS progression. +genetics_knock down_suppress 33220929 hsa-mir-432 Glioma 5p reversed the inhibiting effects of ARRDC1-AS1 knockdown on glioma cells. +target gene 33219943 hsa-mir-194 Carcinoma, Hepatocellular Dual targeting of PD-L1 and PD-L2 by PCED1B-AS1 via sponging hsa-miR-194-5p induces immunosuppression in hepatocellular carcinoma. +genetics_knock down_suppress 33219747 hsa-mir-383 Syphilis miR-383 knockdown ameliorated but miR-383 overexpression facilitated pyroptosis and MIRI. +other 33219358 hsa-mir-23a Depression Future studies further characterizing miR-323a-3p and neuregulin signaling in depression are warranted. +other 33219358 hsa-mir-23 Depression Future studies further characterizing miR-323a-3p and neuregulin signaling in depression are warranted. +other 33219024 hsa-mir-21 Syphilis In a panel of 34 patients with lung adenocarcinoma (LUAD) and 35 healthy donors, HNCIB detected an up-regulated expression of programmed death-ligand 1 mRNA and protein and miR-21 in EVs derived from patients with LUAD compared to those from healthy donors. +other 33219024 hsa-mir-21 Adenocarcinoma of Lung In a panel of 34 patients with lung adenocarcinoma (LUAD) and 35 healthy donors, HNCIB detected an up-regulated expression of programmed death-ligand 1 mRNA and protein and miR-21 in EVs derived from patients with LUAD compared to those from healthy donors. +other 33218492 hsa-mir-675 Pulmonary Fibrosis Recent researches have revealed that miR3p is a promising biomarker for IPF diagnosis. +genetics_overexpression_promote 33218285 hsa-mir-219a-1 Colonic Neoplasms Overexpression of miR-219a-1 in colon cancer cells could inhibit the expression of MEMO1. +circulation_biomarker_diagnosis_ns 33217624 hsa-mir-21 Progeria 5p and decreased abundance of Smad7 there were similar effects in pGCs, including inducing proliferation, inhibiting apoptosis, increasing the number of cells in S and G2/M phases, increasing serum estradiol, and decreasing serum progesterone concentrations. +lncRNA target 33217595 hsa-mir-205 Neuroma, Acoustic CONCLUSIONS: These findings suggested that miR-205 suppressed sporadic VS proliferation by targeting CDK14 and may be considered as a potential drug therapy for sporadic VS treatment in the future. +other 33217568 hsa-mir-16 Breast Neoplasms In silico analysis of the association of hsa-miR-16 expression and cell survival in MDA-MB-231 breast cancer cells subjected to photodynamic therapy. +lncRNA target 33217223 hsa-mir-19a Myocardial Reperfusion Injury METHODS: The I/R rat models were established by coronary artery ligation, which were then treated with RGFP966 (an inhibitor of HDAC3), miR-19a-3p agomir or antagomir, or silenced CDK2 to explore their roles in the cardiac function, pathological changes of myocardial tissues, myocardial infarction area, inflammatory factors and oxidative stress factors in rats with MIRI. +lncRNA target 33216728 hsa-mir-149 Reperfusion Injury, Cerebral Ischemia Therefore, this suggests that miR3p sponging by DLX6-AS1 may lead to cerebral neuron I/R-induced impairments through upregulation of apoptotic BOK activity, which offers a new approach to the treatment of stroke impairment. +exosome 33216617 hsa-mir-107 Fibrous Dysplasia, Polyostotic MiR-107 was downregulated in clinical or experimental PF tissues and also in exosomes from PF-derived ECs. +exosome 33216617 hsa-mir-107 Pulmonary Fibrosis Exosomal miR-107 produced by pulmonary vascular ECs may alleviate pericyte-induced fibrosis by inhibiting a signaling pathway involving HIF-1alpha/Notch1/PDGFRbeta/YAP1/Twist1.NEW & NOTEWORTHY This work reveals a novel mechanism by which pulmonary vascular endothelial cells, via regulating the transdifferentiation of microvascular pericytes into myofibroblasts, contribute to the pathogenesis of pulmonary fibrosis. +other 33215881 hsa-mir-21 Cardiomyopathies Based on the expression of miR-21 and miR-30a-5p, we could sort out patients with DCM from all other study groups (P < 0.05) with the specificity over 95%. +other 33215881 hsa-mir-197 Cardiomyopathies The expression of let-7f, miR-197, miR-223, miR-93, and miR-379 allowed us to differentiate between patients with a virus and/or inflammation and healthy donors (P < 0.05) with the specificity over 93%. +other 33215881 hsa-mir-223 Cardiomyopathies The expression of let-7f, miR-197, miR-223, miR-93, and miR-379 allowed us to differentiate between patients with a virus and/or inflammation and healthy donors (P < 0.05) with the specificity over 93%. +other 33215881 hsa-mir-379 Cardiomyopathies The expression of let-7f, miR-197, miR-223, miR-93, and miR-379 allowed us to differentiate between patients with a virus and/or inflammation and healthy donors (P < 0.05) with the specificity over 93%. +other 33215881 hsa-let-7f Cardiomyopathies The expression of let-7f, miR-197, miR-223, miR-93, and miR-379 allowed us to differentiate between patients with a virus and/or inflammation and healthy donors (P < 0.05) with the specificity over 93%. +other 33215881 hsa-mir-93 Cardiomyopathies The expression of let-7f, miR-197, miR-223, miR-93, and miR-379 allowed us to differentiate between patients with a virus and/or inflammation and healthy donors (P < 0.05) with the specificity over 93%. +other 33215816 hsa-mir-27a Cardiomyopathies miR-27a-5p attenuated TAC-induced cardiac fibrosis and myofibroblast activation in vivo, without a discernible effect on cardiac myocytes. +genetics_GWAS 33215816 hsa-mir-27a Aortic Valve Stenosis We employed a transverse aortic constriction (TAC) murine model of left ventricular pressure overload to investigate the in vivo effects of genetic miR-27a knockout, antisense inhibition of miR-27a-5p and fibroblast-specific miR-27a knockdown or overexpression. +lncRNA target 33215816 hsa-mir-27a Fibrosis The microRNA-27a (miR-27a) regulates collagen production across diverse cell types and organs to inhibit fibrosis and could constitute an important therapeutic avenue. miR-27a-5p attenuated TAC-induced cardiac fibrosis and myofibroblast activation in vivo, without a discernible effect on cardiac myocytes. +genetics_GWAS 33215816 hsa-mir-27a Diarrhea 5, With Tufting Enteropathy, Congenital We employed a transverse aortic constriction (TAC) murine model of left ventricular pressure overload to investigate the in vivo effects of genetic miR-27a knockout, antisense inhibition of miR-27a-5p and fibroblast-specific miR-27a knockdown or overexpression. miR-27a-5p attenuated TAC-induced cardiac fibrosis and myofibroblast activation in vivo, without a discernible effect on cardiac myocytes. +other 33215699 hsa-mir-408 Dehydration These results showed that the improved drought tolerance in Os-miR408 transgenic plants could be due to leaf morphological changes favoring the maintenance of water status and to increased antioxidative capacity protecting against the reactive oxygen species damages under stress. +circulation_biomarker_diagnosis_up 33215544 hsa-mir-1 Muscular Dystrophy, Duchenne Free-circulating miR +circulation_biomarker_diagnosis_up 33215544 hsa-mir-122 Muscular Dystrophy, Duchenne Free-circulating miR +genetics_overexpression_suppress 33215529 hsa-mir-222 Arthritis, Rheumatoid Further experiments confirmed that Sirt1 overexpression restored the anti-RA activity of GAS5 under miR +other 33215510 hsa-mir-1 Osteoarthritis RESULTS: Non-OA and OA chondrocytes differed significantly in the expression of miR-1 and OA-associated genes. +lncRNA target 33215446 hsa-mir-140 Myocardial Reperfusion Injury CONCLUSIONS: MiR-140 suppresses inflammation and apoptosis in myocardial tissues of MIRI rats through inhibiting the NF-kappaB signaling pathway, thereby exerting a cardioprotective effect. +other 33215445 hsa-mir-150 Hyperglycemia At last, rescue experiments were conducted to clarify the role of NORAD/miRNA5p/ZEB1 axis in influencing the proliferation and apoptosis in HG-induced AC16 cells. +other 33215444 hsa-mir-184 Myocardial Infarction This article mainly focused on the regulation of miR-184 on oxidative stress, inflammation, and apoptosis in myocardial infarction (MI). +other 33215443 hsa-mir-1 Necrobiotic Disorders CONCLUSIONS: MiRNA-1 promoted pyroptosis of cardiomyocytes and release of inflammatory factors by downregulating the expression level of PIK3R1. +circulation_biomarker_diagnosis_up 33215440 hsa-mir-122 Mucocutaneous Lymph Node Syndrome CONCLUSIONS: Serum level of miRNA-122 is significantly enhanced in the acute phase of KD, and highly expressed miRNA-122 is related to systematic inflammation. +genetics_overexpression_suppress 33215437 hsa-mir-133b Parkinson Disease Furthermore, overexpression of miR-133b inhibits cell apoptosis in the PD cell model by regulating the ERK1/2 signaling pathway. +lncRNA target 33215433 hsa-mir-19a Breast Neoplasms The purpose of this study is to investigate the expression of long non-coding RNA (LncRNA) FERRE and its facilitating effects on proliferation and invasion of breast cancer by regulating oncogene EZH2 through sponging with miR-19a-5p. CONCLUSIONS: We found that lncRNA-FERRE was upregulated in human breast cancer patients, which could accelerate tumor proliferation, migration and invasion as a molecular sponge by modulating the inhibitory effect of miR-19a-5p on oncogene EZH2. +tissue_expression_ns 33215428 hsa-mir-19a Nasopharyngeal Neoplasms OBJECTIVE: To determine expressions of MicroRNA-19a-3p (miRNA-19a-3p) and PDCD5 in nasopharyngeal carcinoma (NPC) tissues, and their prognostic potentials in NPC. PATIENTS AND METHODS: Expressions of miRNA-19a-3p and PDCD5 in NPC tissues and controls were determined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). The correlation between expressions of miRNA-19a-3p and PDCD5 in NPC was evaluated by Pearson correlation test. Furthermore, potential influences of miRNA-19a-3p and PDCD5 on clinical features of NPC patients were assessed. RESULTS: MiRNA-19a-3p was upregulated and PDCD5 was downregulated in NPC tissues. Pearson correlation test uncovered a negative correlation between expression levels of miRNA-19a-3p and PDCD5 in NPC tissues. MiRNA-19a-3p level was correlated with N classification and clinical stage in NPC patients, while PDCD5 level was correlated with T classification, pathological grade and clinical stage. Survival analysis showed poor prognosis in NPC patients expressing high level of miRNA-19a-3p or low level of PDCD5. Cox regression analysis illustrated that N2+3 classification, clinical stage III+IV, high level of miRNA-19a-3p and low level of PDCD5 were independent risk factors for the prognosis of NPC. CONCLUSIONS: MiRNA-19a-3p is upregulated and PDCD5 is downregulated in NPC tissues. High level of miRNA-19a-3p and low level of PDCD5 are unfavorable for the prognosis of NPC. +genetics_overexpression_promote 33215427 hsa-mir-141 Nasopharyngeal Carcinoma Moreover, overexpression of miR +lncRNA target 33215424 hsa-mir-34a Esophageal Squamous Cell Carcinoma Cellular functional recovery experiments revealed that Linc00888 could modulate the progression of EC by miR-34a. CONCLUSIONS: Linc00888 promotes the proliferative and migration ability of EC through miR-34a. +genetics_knock down_promote 33215421 hsa-mir-149 Carcinoma, Hepatocellular Reverse experiment showed that the knockdown of miR-149 can partially restore the inhibited proliferative, migration, and angiogenesis activity of HCC cells caused by circGFRA1 knockdown. +genetics_knock down_suppress 33215418 hsa-mir-144 Ovarian Neoplasms CONCLUSIONS: These data displayed that the knockdown of HCG11 prevented cell progression in OC by sponging miR +genetics_overexpression_promote 33215417 hsa-mir-582 Osteosarcoma Moreover, overexpression of NOVA1 could impair tumor suppression role of miR +genetics_overexpression_promote 33215415 hsa-mir-29 Osteosarcoma The results revealed that inhibited TMPO-AS1/overexpressed miR-329/inhibited E2F1 suppressed the proliferation and invasion of osteosarcoma cells and enhanced cell apoptosis. +genetics_knock down_promote 33215412 hsa-mir-137 hyperekplexia 1 MiR-137 was down-regulated in samples of KOA patients and was negatively regulated by GAS5. CONCLUSIONS: GAS5 is up-regulated in KOA serum, cartilage tissues and cells, and can induce chondrocyte apoptosis through down-regulating miR-137. +lncRNA target 33215409 hsa-mir-210 Pre-Eclampsia CONCLUSIONS: MiR-210 inhibits apoptosis via suppressing the TGF-beta signaling pathway, thereby exerting a protective effect on cranial nerves in PE rats. +other 33215408 hsa-mir-222 Pre-Eclampsia 5p in the proliferative and migratory potentials of trophoblast cell line HTR-8/SVneo. +other 33215408 hsa-mir-222 Pneumonia, Mycoplasma 5p was downregulated in placental tissues of PE pregnancies. +genetics_knock down_promote 33215222 hsa-mir-197 Stomach Neoplasms Furthermore, JPX knockdown regulated GC cell phenotype by promoting miR197. +lncRNA target 33215214 hsa-mir-493 Squamous Cell Carcinoma of Head and Neck In conclusion, these results suggested that LUCAT1 may facilitate tumorigenesis in LSCC through the targeted inhibition of miR493, which provides evidence for a novel target for the treatment of LSCC. +other 33213115 hsa-mir-20a Diabetic Retinopathy The aim of this study is to evaluate the levels of five candidate miRNAs (miR-29c-3p, miR-18a, miR-31, miR-181 and miR-20a) in patients with diabetic retinopathy (DR) and their relationship with disease severity. +other 33213115 hsa-mir-181 Diabetic Retinopathy The aim of this study is to evaluate the levels of five candidate miRNAs (miR-29c-3p, miR-18a, miR-31, miR-181 and miR-20a) in patients with diabetic retinopathy (DR) and their relationship with disease severity. +other 33213115 hsa-mir-18a Diabetic Retinopathy The aim of this study is to evaluate the levels of five candidate miRNAs (miR-29c-3p, miR-18a, miR-31, miR-181 and miR-20a) in patients with diabetic retinopathy (DR) and their relationship with disease severity. +circulation_biomarker_diagnosis_down 33213115 hsa-mir-29c Diabetic Retinopathy CONCLUSIONS: Plasma miR-29c-3p expression is downregulated in diabetic patients with and without retinopathy, and changes in this miRNA are an independent risk factor for the development of DR. +other 33213115 hsa-mir-1 Diabetic Retinopathy The aim of this study is to evaluate the levels of five candidate miRNAs (miR-29c-3p, miR-18a, miR-31, miR-181 and miR-20a) in patients with diabetic retinopathy (DR) and their relationship with disease severity. +other 33212990 hsa-mir-27 Carcinoma, Hepatocellular Notably, we found that miR-27b controls post-transcriptional expression of numerous components of the insulin signaling pathway including the insulin receptor (INSR) and insulin receptor substrate 1 (IRS1) in human hepatoma cells. +transcription factor target 33212990 hsa-mir-27b Liver Diseases Therefore, assessment of the impact of miR-27b on insulin resistance through the hepatic tissue is of special importance due to the high expression of miR-27b in the liver together with its known role in regulating lipid metabolism. +other 33212990 hsa-mir-27b Carcinoma, Hepatocellular Notably, we found that miR-27b controls post-transcriptional expression of numerous components of the insulin signaling pathway including the insulin receptor (INSR) and insulin receptor substrate 1 (IRS1) in human hepatoma cells. +genetics_overexpression_promote 33212990 hsa-mir-27 Liver Diseases These results were further confirmed in vivo showing that overexpression and inhibition of hepatic miR-27 enhances and suppresses hepatic INSR expression and insulin sensitivity, respectively. +virus_miRNA 33212952 mdv1-mir-M10 Marek Disease MDV cluster 3 miRNAs play an important role in modulating MDV pathogenesis +virus_miRNA 33212952 mdv1-mir-M8 Marek Disease MDV cluster 3 miRNAs play an important role in modulating MDV pathogenesis +virus_miRNA 33212952 mdv1-mir-M9 Marek Disease MDV cluster 3 miRNAs play an important role in modulating MDV pathogenesis +lncRNA target 33212147 hsa-mir-615 Epilepsy Our findings revealed that Nespas suppressed the apoptosis of epileptiform hippocampal neurons by inhibiting the PI3K/Akt/mTOR pathway via upregulation of Psmd11 at a miR +other 33212095 hsa-mir-29a Cardiomyopathy, Hypertrophic Correlation with left ventricular hypertrophy and fibrosis was evaluated in six studies for several miRNAs, nevertheless, mir-29a showed more consistent findings and seems to be a promising biomarker. +other 33212095 hsa-mir-21 Cardiomyopathy, Hypertrophic Eighty-seven miRNA were differentially expressed in HCM patients, being mir-21, mir-29a and mir-133 the most reported. +other 33212095 hsa-mir-133 Cardiomyopathy, Hypertrophic Eighty-seven miRNA were differentially expressed in HCM patients, being mir-21, mir-29a and mir-133 the most reported. +other 33211633 hsa-mir-133b Colorectal Neoplasms CONCLUSION: EGFR-AS1 may have a role in colorectal cancer by regulation of miR133b/EGFR/STAT3 signalling. +other 33211275 hsa-mir-574 Pre-Eclampsia GAB1 was downregulated in placenta of PE patients, which was positively correlated with EGR1 and negatively correlated with miR-574. +lncRNA target 33211221 hsa-mir-617 psoriasis 1 stimulated keratinocytes through targeting FOXO4, which provides a new therapeutic target for psoriasis. +genetics_knock down_promote 33211058 hsa-mir-451a Inflammation Significantly upregulated expression of miR-451a was found in septic patients with cardiac dysfunction, and the knockdown of miR-451a in sepsis rats improved cardiac function and inhibited inflammatory responses. +genetics_knock down_promote 33211058 hsa-mir-451a Sepsis Significantly upregulated expression of miR-451a was found in septic patients with cardiac dysfunction, and the knockdown of miR-451a in sepsis rats improved cardiac function and inhibited inflammatory responses. +genetics_knock down_promote 33211058 hsa-mir-451a Shock, Septic Significantly upregulated expression of miR-451a was found in septic patients with cardiac dysfunction, and the knockdown of miR-451a in sepsis rats improved cardiac function and inhibited inflammatory responses. +genetics_overexpression_suppress 33210605 hsa-mir-199a Hepatitis B, Chronic The targeted inhibition of MAGT1 induced by miR-199a-5p overexpression led to the immune function depletion of CD8(+)T cells in HBV patients. +lncRNA target 33210593 hsa-mir-1 Arrhythmias, Cardiac 3p inhibitor was administered via the tail vein, and the other treatment were the same as the model group). +lncRNA target 33210592 hsa-mir-23b Uterine Cervical Neoplasms Objective To investigate the effects of miR-23b-3p on proliferation, migration and invasion of human cervical carcinoma CasKi cells. Conclusion Over-expression of miR-23b-3p may suppress the proliferation, migration, invasion and epithelial-mesenchymal transition process of human cervical cancer CasKi cells. +lncRNA target 33210543 hsa-mir-767 Carcinoma, Hepatocellular Additionally, this study demonstrated that RP11-909N17.2 facilitates the proliferation and invasion of HCC cells by binding to miRNA3p, a tumor-suppressive microRNA (miRNA). +genetics_overexpression_promote 33210473 hsa-mir-362 Uterine Cervical Neoplasms Overexpression of miR-362 might be a potential therapeutic strategy for cervical cancer. +other 33210454 hsa-mir-186 Carcinoma, Hepatocellular Mechanistically, we demonstrated that circ_0008305 up-regulated TMED2 expression by sponging miR-186, which resulted in significantly induced HCC progression in vitro and in vivo. +lncRNA target 33210403 hsa-mir-326 Endometrial Neoplasms CONCLUSION: MiR-326 acts as a cancer suppressor to inhibit proliferation and promote apoptosis via targeting Bcl-2 axis in EC. +other 33210166 hsa-mir-22 Arthritis, Rheumatoid 3p, and miR-155 were significantly altered in RA patients compared to those in controls. +other 33210166 hsa-mir-26b Arthritis, Rheumatoid 3p, and miR-155 were significantly altered in RA patients compared to those in controls. +other 33210166 hsa-mir-155 Arthritis, Rheumatoid 3p, and miR-155 were significantly altered in RA patients compared to those in controls. +other 33210166 hsa-mir-142 Arthritis, Rheumatoid 3p, and miR-155 were significantly altered in RA patients compared to those in controls. +circulation_biomarker_diagnosis_up 33209976 hsa-mir-526b Osteosarcoma The expression levels of circ_0085539, miR-526b-5p, and stress-associated endoplasmic reticulum protein 1 (SERP1) mRNA in OS tissues and cells were detected and analyzed by qRT-PCR. +other 33209893 hsa-mir-138 Carcinoma, Non-Small-Cell Lung Long non-coding RNA TRPM2-AS sponges microRNA-138-5p to activate epidermal growth factor receptor and PI3K/AKT signaling in non-small cell lung cancer. +lncRNA target 33209876 hsa-mir-103a Immune System Diseases CONCLUSIONS: HMGB1 is targeted by miR-103a-3p, which may be a new strategy in the treatment of CI/R. +lncRNA target 33209876 hsa-mir-103a Brain Ischemia CONCLUSIONS: HMGB1 is targeted by miR-103a-3p, which may be a new strategy in the treatment of CI/R. +target gene 33209874 hsa-mir-377 Carcinoma, Hepatocellular LncRNA HULC shRNA disinhibits miR-377-5p to suppress the growth and invasion of hepatocellular carcinoma in vitro and hepatocarcinogenesis in vivo. +other 33209873 hsa-mir-132 gastric adenocarcinoma MIR-331 and MIR-132 have important role in STAD. +other 33209873 hsa-mir-31 gastric adenocarcinoma MIR-331 and MIR-132 have important role in STAD. +exosome 33209688 hsa-mir-23b Nephrotic Syndrome Results of receiver operating curve (ROC) curve analysis showed that urinary exosomal miR-23b-3p and miR-30a-5p can be used to identify children with NS and healthy children. +other 33209671 hsa-mir-410 Retinitis Pigmentosa 3p levels were lower in RP tissue than in control nRP tissues. +other 33209671 hsa-mir-410 Plaque, Amyloid METHODS: Quantitative polymerase chain reaction (qPCR) analysis was used to assess the expression levels of miRNA3p in Randall's plaque (RP) and normal renal papillary (nRP) tissues. +genetics_overexpression_promote 33209494 hsa-mir-5589 Carcinoma, Hepatocellular Moreover, ERCC6L promoter hypomethylation and miR-5589 downregulation in HCC might result in ERCC6L overexpression (all P<0.05). +other 33209488 hsa-mir-424 Colorectal Neoplasms CircTBL1XR1/miR-424 axis regulates Smad7 to promote the proliferation and metastasis of colorectal cancer. +exosome 33209394 hsa-mir-382 Atrial Fibrillation 5p contained in exosomes in human PF are pivotal in the progression of AF. +transcription factor target 33209394 hsa-mir-126 Atrial Fibrillation 3p) 283 predicted target genes were identified, and were implicated in cardiac fibrosis-related pathways, including the hypoxia-inducible factor-1 (HIF1), mitogen-activated protein kinase (MAPK), and adrenergic and insulin pathways. +transcription factor target 33209394 hsa-mir-450a-2 Atrial Fibrillation 3p) 283 predicted target genes were identified, and were implicated in cardiac fibrosis-related pathways, including the hypoxia-inducible factor-1 (HIF1), mitogen-activated protein kinase (MAPK), and adrenergic and insulin pathways. +transcription factor target 33209201 hsa-mir-122 Diabetic Retinopathy miR-122 promoted diabetic retinopathy through targeting TIMP3, making miR-122 a promising target for diabetic retinopathy therapy. +circulation_biomarker_diagnosis_up 33209200 hsa-mir-637 Stomach Neoplasms Upregulating miR-637 aggravates endoplasmic reticulum stress-induced apoptosis in gastric cancer cells by suppressing Calreticulin. +other 33209193 hsa-mir-425 Intervertebral disc disease miR5p expression was negatively correlated with Bcl2 expression in IDD tissues. +other 33209193 hsa-mir-424 Neurodegenerative Diseases Our results showed that the expression of miR5p was increased and Bcl2 was decreased in degenerative NP cells. +other 33209193 hsa-mir-424 idiopathic scoliosis Real-time PCR was used to detect the expression of miR5p and Bcl2 in IDD tissues and idiopathic scoliosis tissues. +transcription factor target 33209193 hsa-mir-424 Intervertebral disc disease 5p might be a novel target for IDD therapies. +circulation_biomarker_diagnosis_up 33209036 hsa-mir-23b Prostatic Neoplasms In comparison to the healthy controls, the expression levels of miR-217 were significantly upregulated, while miR-23b-3p were significantly downregulated in the exosomes and serum collected from PCa patients. +circulation_biomarker_diagnosis_up 33209036 hsa-mir-217 Prostatic Neoplasms In comparison to the healthy controls, the expression levels of miR-217 were significantly upregulated, while miR-23b-3p were significantly downregulated in the exosomes and serum collected from PCa patients. +transcription factor target 33209030 hsa-mir-532 Depression 5p may be a potential target for MDD therapy. +circulation_biomarker_diagnosis_ns 33208870 hsa-mir-200 Ovarian Neoplasms Hence, miR-200 is informative as blood biomarkers for both human and laying hen ovarian cancer. +other 33208870 hsa-mir-429 Ovarian Neoplasms Subtype-specific analysis showed that miR-200b had an overall elevated level in serous cancer compared with controls, whereas miR-429 was significantly elevated in clear cell and endometrioid cancer versus controls. +other 33208870 hsa-mir-200b Ovarian Neoplasms Subtype-specific analysis showed that miR-200b had an overall elevated level in serous cancer compared with controls, whereas miR-429 was significantly elevated in clear cell and endometrioid cancer versus controls. +lncRNA target 33208781 hsa-mir-148a Esophageal Squamous Cell Carcinoma Through a series of screening, miR-34a-5p, miR-148a-3p and miR-181a-5p were selected as EC-associated miRNAs. +lncRNA target 33208781 hsa-mir-181a Esophageal Squamous Cell Carcinoma Through a series of screening, miR-34a-5p, miR-148a-3p and miR-181a-5p were selected as EC-associated miRNAs. +lncRNA target 33208781 hsa-mir-34a Esophageal Squamous Cell Carcinoma Through a series of screening, miR-34a-5p, miR-148a-3p and miR-181a-5p were selected as EC-associated miRNAs. +lncRNA target 33208727 hsa-mir-210 Glioblastoma Briefly, in a hypoxic microenvironment the HIF1alpha/HIF2alpha-miR210-3p network promotes the malignant progression of glioblastoma through a positive feedback loop with EGF. +other 33208444 hsa-let-7b Hepatitis C Controlling let-7b expression is thereby crucial in the intervention of HCV infection.IMPORTANCE HCV is a leading cause of liver disease, with an estimated 71 million people infected worldwide. +other 33208381 hsa-mir-182 Infections Its multiplex regulations on the simultaneous production of IL-17f and IL-10, TLR4 signaling pathway and the number of corneal ResMvarphi place miR-183/96/182 in the center of corneal innate immunity, which is key to the homeostasis of the cornea, ocular immune privilege, and the corneal response to microbial infections. +other 33208381 hsa-mir-182 Bacterial Infections Its multiplex regulations on the simultaneous production of IL-17f and IL-10, TLR4 signaling pathway and the number of corneal ResMvarphi place miR-183/96/182 in the center of corneal innate immunity, which is key to the homeostasis of the cornea, ocular immune privilege, and the corneal response to microbial infections. +other 33208381 hsa-mir-183 Infections Its multiplex regulations on the simultaneous production of IL-17f and IL-10, TLR4 signaling pathway and the number of corneal ResMvarphi place miR-183/96/182 in the center of corneal innate immunity, which is key to the homeostasis of the cornea, ocular immune privilege, and the corneal response to microbial infections. +other 33208381 hsa-mir-96 Bacterial Infections Its multiplex regulations on the simultaneous production of IL-17f and IL-10, TLR4 signaling pathway and the number of corneal ResMvarphi place miR-183/96/182 in the center of corneal innate immunity, which is key to the homeostasis of the cornea, ocular immune privilege, and the corneal response to microbial infections. +other 33208381 hsa-mir-96 Infections Its multiplex regulations on the simultaneous production of IL-17f and IL-10, TLR4 signaling pathway and the number of corneal ResMvarphi place miR-183/96/182 in the center of corneal innate immunity, which is key to the homeostasis of the cornea, ocular immune privilege, and the corneal response to microbial infections. +other 33208381 hsa-mir-183 Bacterial Infections Its multiplex regulations on the simultaneous production of IL-17f and IL-10, TLR4 signaling pathway and the number of corneal ResMvarphi place miR-183/96/182 in the center of corneal innate immunity, which is key to the homeostasis of the cornea, ocular immune privilege, and the corneal response to microbial infections. +lncRNA target 33208342 hsa-mir-155 Lymphoma, B-Cell Thus, miR-155 inhibition represents an important therapeutic strategy for B-cell lymphomas. +other 33208058 hsa-mir-181a Depression Only miR-181a has no direct evidence to be involved in the mechanism of MD. +other 33208058 hsa-mir-181a Migraine Disorders Only miR-181a has no direct evidence to be involved in the mechanism of MD. +lncRNA target 33208053 hsa-mir-15b Nerve Degeneration CONCLUSION: LINC00943 inhibition alleviated MPP(+)-induced neuronal injury via miR-15b-5p/RAB3IP axis, indicating a potential target for treatment of PD. +lncRNA target 33208053 hsa-mir-15b late onset Parkinson's disease CONCLUSION: LINC00943 inhibition alleviated MPP(+)-induced neuronal injury via miR-15b-5p/RAB3IP axis, indicating a potential target for treatment of PD. +genetics_knock down_suppress 33208005 hsa-mir-363 Stomach Diseases Knockdown of miR +circRNA target 33207953 hsa-mir-22 Endometrial Hyperplasia Targeting the circMAP3K5/miR3p/TET2 axis may provide a potential therapeutic strategy for diseases associated with intimal hyperplasia, including restenosis and atherosclerosis. +lncRNA target 33207945 hsa-mir-217 Lung Injury MicroRNA-217 (miR-217) is proved to be involved in controlling inflammatory response and oxidative stress, yet its role and underlying mechanism in the pathogenesis of septic lung injury remain elusive. Our data defined miR-217 as a therapeutic target for treating septic lung injury. +lncRNA target 33207945 hsa-mir-217 Sepsis MicroRNA-217 (miR-217) is proved to be involved in controlling inflammatory response and oxidative stress, yet its role and underlying mechanism in the pathogenesis of septic lung injury remain elusive. Our data defined miR-217 as a therapeutic target for treating septic lung injury. +genetics_overexpression_promote 33207890 hsa-mir-101 Colonic Neoplasms Overexpression of EZH2 promoted CRC cell line migration and this effect was inhibited by forcing the expression of miR-101. +lncRNA target 33207859 hsa-mir-29a Osteoporosis Subsequently, we found that miR-29a-3p is the target of lncRNA H19 in OP. +circulation_biomarker_diagnosis_ns 33207343 hsa-mir-486 Sleep Apnea, Obstructive Nevertheless, miR-107 and miR-143 are associated with specific blood pressure parameters in patients with OSA and miR-486 is associated with the cardiovascular risk SCORE. +circulation_biomarker_diagnosis_ns 33207343 hsa-mir-107 Sleep Apnea, Obstructive Nevertheless, miR-107 and miR-143 are associated with specific blood pressure parameters in patients with OSA and miR-486 is associated with the cardiovascular risk SCORE. +circulation_biomarker_diagnosis_ns 33207343 hsa-mir-143 Sleep Apnea, Obstructive Nevertheless, miR-107 and miR-143 are associated with specific blood pressure parameters in patients with OSA and miR-486 is associated with the cardiovascular risk SCORE. +lncRNA target 33207024 hsa-mir-204 Glomerulonephritis, Membranous The mRNA SOX4 might contribute to MN progression via sponging KCNQ1OT1-miR5p interaction. +lncRNA target 33206628 hsa-mir-155 Heart Failure HF rats presented with downregulated expressions of Sirt1, brain-derived neurotrophic factor (BDNF) and exhibited upregulated expressions of NF-kappaB p65 and miR-155. In conclusion, Sirt1 alleviates HF in rats through the NF-kappaB p65/miR-155/BDNF signaling cascade. +exosome 33206588 hsa-mir-451a Carcinoma, Hepatocellular HucMSC-derived exosomal miR-451a could restrict the epithelial-mesenchymal transition of HCC cells by targeting ADAM10, which might provide new targets for HCC treatment. +other 33206331 hsa-mir-21 Liver Neoplasms CONCLUSION: CT combined with miR-21 has great diagnostic value in liver cancer and may be a potential diagnostic indicator for liver cancer. +circulation_biomarker_diagnosis_ns 33206330 hsa-mir-21 Breast Neoplasms CONCLUSIONS: Color Doppler ultrasound combined with plasma miR-21 and miR-27a can significantly improve the diagnostic efficiency of BC, which is beneficial to early diagnosis and early clinical intervention. +circulation_biomarker_diagnosis_ns 33206330 hsa-mir-27a Breast Neoplasms CONCLUSIONS: Color Doppler ultrasound combined with plasma miR-21 and miR-27a can significantly improve the diagnostic efficiency of BC, which is beneficial to early diagnosis and early clinical intervention. +genetics_knock down_promote 33206218 hsa-mir-29a Influenza, Human Knockout of miR-29a using CRISPR/Cas9 resulted in an increase in viral mRNA and protein levels, confirming that miR-29a suppresses IAV infection. +other 33206203 hsa-mir-146a Obesity The aim of this study was to characterize the role of miR-146a in obesity and insulin resistance. +other 33206203 hsa-mir-146a Insulin Resistance The aim of this study was to characterize the role of miR-146a in obesity and insulin resistance. +lncRNA target 33205911 hsa-mir-423 Adenocarcinoma of Lung 5p aggravated lung adenocarcinoma via downregulation of CADM1 expression. +circRNA target 33205602 hsa-mir-599 Osteoarthritis Here, we report circANKRD36 prevents OA chondrocyte apoptosis and inflammation by targeting miR-599, which specifically degrades Casz1. In conclusion, our results proved circANKRD36 sponge miR-599 to up-regulate the expression of Casz1 and thus prevent apoptosis and inflammation in OA. +lncRNA target 33205517 hsa-mir-99b Leukemia 5-LO inhibits the formation of let-7e which is a well-known inducer of cell differentiation, but promotes the generation of miR-99b and miR-125a known to induce cell proliferation and the maintenance of leukemic stem cell functions. +lncRNA target 33205517 hsa-let-7e Leukemia 5-LO inhibits the formation of let-7e which is a well-known inducer of cell differentiation, but promotes the generation of miR-99b and miR-125a known to induce cell proliferation and the maintenance of leukemic stem cell functions. +lncRNA target 33205517 hsa-mir-125a Leukemia 5-LO inhibits the formation of let-7e which is a well-known inducer of cell differentiation, but promotes the generation of miR-99b and miR-125a known to induce cell proliferation and the maintenance of leukemic stem cell functions. +lncRNA target 33205379 hsa-mir-25 Inflammation Our results identified that the silencing of H19 attenuated LPS-evoked microglia cell apoptosis and inflammation after SCI at least partially through targeting the miR +lncRNA target 33205379 hsa-mir-25 Spinal Cord Injuries Our results identified that the silencing of H19 attenuated LPS-evoked microglia cell apoptosis and inflammation after SCI at least partially through targeting the miR3p/NEUROD4 axis, highlighting a novel approach for SCI management. +other 33204711 hsa-mir-141 Parkinson Disease phenylpyridinium- (MPP+-) induced PC12-cell model of PD. +target gene 33204608 hsa-mir-296 Osteosarcoma ELF1-activated FOXD3-AS1 promotes the migration, invasion and EMT of osteosarcoma cells via sponging miR-296-5p to upregulate ZCCHC3. +transcription factor target 33204341 hsa-mir-138 Osteoporosis 5p as a mechanoresponsive miRNA accounts for the mechanosensitivity of the bone anabolic response and that inhibition of miR +other 33204341 hsa-mir-138 Mobility Limitation Results: Here, we found increased miR5p levels with a lower degree of bone formation in bone specimens from bedridden and aged patients. +lncRNA target 33204326 hsa-mir-142a Nephrocalcinosis Conclusions: Our results indicated that AhR activation could diminish M1 macrophage polarization and promote M2 macrophage polarization to suppress CaOx nephrocalcinosis via the AhR-miR-142a-IRF1/HIF-1alpha pathway. +circulation_biomarker_diagnosis_ns 33204323 hsa-mir-452 Acute Kidney Injury Spearman's test demonstrated a remarkable positive correlation between urinary miR-452 and serum creatinine in sepsis patients (r=0.8269). +circulation_biomarker_diagnosis_ns 33204323 hsa-mir-452 Sepsis Spearman's test demonstrated a remarkable positive correlation between urinary miR-452 and serum creatinine in sepsis patients (r=0.8269). +genetics_overexpression_promote 33204298 hsa-mir-139 Adenocarcinoma of Lung 5p overexpression on LUAD cell proliferation, migration, and invasion was attenuated by overexpressing MAD2L1. +lncRNA target 33204264 hsa-mir-203 Esophageal Neoplasms Upregulated UCA1 in EC cells significantly suppressed the degradation of HK2 by miR-203. In sum, our findings suggest that the UCA1/miR-203/HK2 axis contributes to EC development by reprogramming tumor glucose metabolism, providing new insight into the management of EC patients. +genetics_knock down_promote 33204164 hsa-mir-376a Carcinoma, Non-Small-Cell Lung CONCLUSION: Our findings first identified that the knockdown of circSEC31A suppressed NSCLC malignant progression at least partly through modulating SEC31A expression by acting as a miR-376a sponge, providing a novel molecular target of NSCLC therapy. +genetics_overexpression_promote 33204160 hsa-mir-105 Squamous Cell Carcinoma of Head and Neck Furthermore, miR-105 overexpression can significantly promote the proliferation and invasion of OSCC cells, whereas downregulation of miR-105 inhibits these cellular events. +lncRNA target 33204157 hsa-mir-759 Colorectal Neoplasms Furthermore, miR-759 inhibitors or SPRR3 ectopic expression partially rescued the abilities of proliferation, migration and invasion in CRC cells transfected with sh-PCAT18. CONCLUSION: Therefore, our study demonstrated that PCAT18 contributes to CRC progression through regulating miR-759/SPRR3 axis, which provides a new theoretical basis of explaining CRC tumorigenesis. +target gene 33204155 hsa-mir-195 Uterine Cervical Neoplasms lncRNA SNHG1 Promotes Progression of Cervical Cancer Through miR-195/NEK2 Axis. +transcription factor target 33204152 hsa-mir-141 Colonic Neoplasms CONCLUSION: miR-141 promotes CC cell proliferation by targeted silencing PHLPP2. +lncRNA target 33204108 hsa-mir-139 Stomach Neoplasms CONCLUSION: CTBP1-AS2 promotes GC cells and inhibits apoptosis by regulating the miR +circulation_biomarker_diagnosis_ns 33204094 hsa-mir-139 Depressive Disorder, Major The ROC curve showed that serum-derived miR +lncRNA target 33204092 hsa-mir-4686 Glioma CONCLUSION: Our study suggested tumor cells derived exo-ROR1-AS1 promoted glioma progression by inhibiting miR-4686, which might be a potential therapeutic target for glioma clinical treatment. +transcription factor target 33204070 hsa-mir-200a Eunuchism Therefore, miR-200a might serve as a new therapeutic target for the treatment of male hypogonadism. +other 33204070 hsa-mir-200a Arrest of spermatogenesis Previous research has indicated that the level of miR-200a was significantly upregulated in patients with different spermatogenic impairments. However, the mechanism by which miR-200a regulated spermatogenic impairments remains unclear. +lncRNA target 33204065 hsa-mir-206 Nervous System Diseases Mechanistically, KCNQ1OT1 could target miR-206 and reduce its expression level, in turn indirectly increase the expression level of BDNF, and play a protective role in neural injury. +other 33204001 hsa-mir-185 Nasopharyngeal Carcinoma 3p to upregulate the FOXD3 expression, thereby promoting the development of NPC. +other 33203802 hsa-mir-21 Vascular Diseases In this study, we provide evidence that HCG18/miR5p/SOX7/VE-cadherin signaling is involved in PM2.5-induced vascular endothelial barrier dysfunction. +genetics_knock down_promote 33203695 hsa-mir-135a Diabetic Nephropathies Mechanistically, we identified that a loss of circRNA_010383 promoted proteinuria and renal fibrosis in DN by acting as a sponge for miRNA-135a. +genetics_knock down_promote 33203695 hsa-mir-135a Fibrosis, Renal Mechanistically, we identified that a loss of circRNA_010383 promoted proteinuria and renal fibrosis in DN by acting as a sponge for miRNA-135a. +genetics_overexpression_promote 33203523 hsa-mir-637 Thyroid Cancer, Papillary Circ_PSD3 silencing-induced effects in PTC cells were partly attenuated by the addition of anti-miR-637 or HEMGN overexpression plasmid. +circulation_biomarker_diagnosis_up 33203292 hsa-mir-135b Asthma METHODS: The expressions of miR-135b and CXCL12 were detected using quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) in the serum of asthmatic children. +circulation_biomarker_diagnosis_up 33203292 hsa-mir-135b Pneumonia METHODS: The expressions of miR-135b and CXCL12 were detected using quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) in the serum of asthmatic children. +circulation_biomarker_diagnosis_ns 33202891 hsa-mir-615 Melanoma Compared to LDH levels during CII, circulating miR3p levels were consistently more efficient in detecting melanoma patients undergoing CII who developed progressive disease. +lncRNA target 33202602 hsa-mir-181b Breast Neoplasms Numerous studies have reported dysregulation of miRNA-141, miR-181b1, and miR-23b in a wide range of malignancies, including breast cancer. +lncRNA target 33202602 hsa-mir-141 Breast Neoplasms Numerous studies have reported dysregulation of miRNA-141, miR-181b1, and miR-23b in a wide range of malignancies, including breast cancer. +other 33202583 hsa-mir-146a Tuberculosis, Pulmonary Both miR-23a-3p and miR-146a-5p gene expressions were decreased in active TB patients with high bacterial burden versus those with low bacterial burden or control group (LTBI NIHS). +transcription factor target 33202583 hsa-mir-23a Tuberculosis, Pulmonary In conclusion, the down-regulation of miR-23a-3p in active TB patients with high bacterial burden inhibited mononuclear cell function and phagocytosis through TLR4/TNF-alpha/TGF-beta1/IL-10 signaling via targeting IRF1/SP1. +genetics_overexpression_promote 33202380 hsa-mir-200b Melanoma Overexpression of miR-200b-3p significantly inhibited the proliferation and invasion of melanoma cells. +genetics_knock down_promote 33202146 hsa-mir-574 Respiratory Distress Syndrome 5p suppresses alveolar leukocytes infiltration, interstitial edema, protein effusion, and inflammation. +lncRNA target 33201900 hsa-mir-424 Carcinoma, Hepatocellular 5p inhibited the proliferation of HCC cells and blocked cell cycle at G0/G1 phase by targeting E2F7. +circulation_biomarker_diagnosis_ns 33201565 hsa-mir-221 Arthritis, Gouty 5p had lower expression in the serum of AGA patients. +genetics_knock down_promote 33201331 hsa-mir-665 Stomach Neoplasms CONCLUSION: Circ-PRRX1 knockdown suppressed GC development by targeting miR-665 to inhibit YWHAZ expression, and the potential molecular mechanism may provide a theoretical basis for GC therapy. +genetics_GWAS 33201243 hsa-mir-564 Leukemia, Myeloid, Acute Ectopic expression of miR564 can induce retardation of G1/S transition, reperform differentiation, promote apoptosis, as well as inhibit the proliferation and colony formation of AML1-ETO+ leukemia cells in vitro. We first identify an unexpected and important epigenetic circuitry of AML1-ETO/miR564/CCND1/DNMT3A that contributes to the leukemogenesis in vitro/vivo of AML1-ETO+ leukemia, indicating that miR564 enhancement could provide a potential therapeutic method for AML1-ETO+ leukemia. +other 33201038 hsa-mir-21 Brain Injuries, Traumatic Growing evidence for specific miRNAs, including miR21, as TBI biomarkers is presented. +genetics_overexpression_promote 33200802 hsa-mir-744 Colorectal Neoplasms Overexpression of SEPT2 counteracted the suppressive effect of miR7445p on the proliferation and apoptosis of CRC cells. +transcription factor target 33200800 hsa-mir-194 Keloid The present study indicated that the novel miR/1945p/NR2F2 interactome might be involved in the progression of keloid aggression and may serve as a potential therapeutic target for human keloid in the future. +other 33200798 hsa-mir-21 Vitiligo Furthermore, in patients with VIT, microRNA (miR)215p expression was decreased, while that of STAT3 was increased. +genetics_overexpression_promote 33200797 hsa-mir-140 Multiple Myeloma Further experiments indicated that VEGFA overexpression promoted cell viability, migration and invasion and suppressed apoptosis of MM cells, and that the miR1405p mimic partially reversed the effects of VEGFA overexpression. +lncRNA target 33200790 hsa-mir-4530 Glioma The miR-4530/RTEL1 axis is a potential therapeutic target for gliomas. +transcription factor target 33200777 hsa-mir-3677 Carcinoma, Hepatocellular 3p may serve as a potential diagnostic biomarker or a therapeutic target for HCC. +lncRNA target 33200535 hsa-mir-144 Reperfusion Injury, Renal Ischemia In conclusion, our study suggests that the circAKT3 is involved RI/R injury progression through regulating miR +circRNA target 33200464 hsa-mir-378 Osteoporosis, Postmenopausal Targeting the circ_0007059/miR-378/BMP-2 axis is possibly a novel idea in osteoporosis treatment. +lncRNA target 33200343 hsa-mir-133a gastric cardia adenocarcinoma CONCLUSION: LINC01503 serves as an oncogenic lncRNA to promote GCA progression via affecting LINC01503/miR-133a-5p/VIM axis and EMT process. +circulation_biomarker_diagnosis_ns 33200255 hsa-mir-371a Testicular Neoplasms PURPOSE: Serum levels of microRNA-371a-3p (M371) have been shown to be a highly sensitive and specific biomarker for testicular germ cell tumours (TGCT). +other 33200222 hsa-mir-758 Urinary Bladder Neoplasms RTqPCR, EdU, CCK8, wound scratch, Transwell and flow cytometric assays were performed to detect CASC9 expression, miR7583p expression and their functions in BC. Collectively, these results indicated that CASC9 sponged miR7583p to regulate the expression of TGFbeta2, which activated the TGFbeta signaling pathway and promoted proliferation and EMT in BC. +lncRNA target 33199996 hsa-mir-28 Fractures, Bone 3p in the regulation of osteoblastic viability. +circulation_biomarker_prognosis_ns 33198870 hsa-mir-92a Respiratory Distress Syndrome CONCLUSIONS: The expression levels of serum miR-92a, miR-146a and LUS score are related to the severity and prognosis of the patients with ARDS, and the combination of the three indicators has better value in predicting the prognosis of the patients with ARDS. +circulation_biomarker_prognosis_ns 33198870 hsa-mir-146a Respiratory Distress Syndrome CONCLUSIONS: The expression levels of serum miR-92a, miR-146a and LUS score are related to the severity and prognosis of the patients with ARDS, and the combination of the three indicators has better value in predicting the prognosis of the patients with ARDS. +circRNA target 33198772 hsa-mir-99a Stomach Neoplasms Inhibition of miR-99a-5p could sensitize GC cells to CDDP. CONCLUSIONS: CircMCTP2 sensitizes GC to CDDP through the upregulation of MTMR3 by sponging miR-99a-5p. +other 33198388 hsa-mir-107 Atrial Fibrillation 3p andmiR-107 and lower miR-146a-5p levels were associated with a higher risk of MACE. +other 33198388 hsa-mir-146a Atrial Fibrillation 3p andmiR-107 and lower miR-146a-5p levels were associated with a higher risk of MACE. +lncRNA target 33197895 hsa-mir-497 Thyroid Cancer, Papillary Moreover, inhibition of miR-497 abrogated the inhibitory effects of DLG1-AS1 depletion on PTC cells. +other 33197880 hsa-mir-210 Obesity We demonstrated that hypoxia pathways were repressed in obese patients by regulating miR-210. +other 33197880 hsa-mir-210 Colonic Neoplasms We demonstrated that hypoxia pathways were repressed in obese patients by regulating miR-210. +circulation_biomarker_diagnosis_up 33197745 hsa-mir-15a Pre-Eclampsia miR-15a-5p was found upregulated in exosomes isolated from maternal plasma of PE pregnant women as compared to those from normal pregnant women. +genetics_overexpression_promote 33197602 hsa-mir-200a Inflammation CONCLUSION: The results showed that miR-200a expression was inhibited in murine cardiomyocytes due to H(2)O(2) stress in MI cardiac tissues and overexpressed miR-200a could protect the cells from death by regulating the Keap1/Nrf2 and beta-catenin signal transduction pathways. +lncRNA target 33197504 hsa-mir-214 Alzheimer Disease Our findings demonstrate that silencing of BACE1-AS alleviated neuronal injury by regulating autophagy through the miR3p/ATG5 signalling axis in AD. +transcription factor target 33197444 hsa-mir-202 Endometriosis 3p targeted YAP1 to reduce STAT3-mediated S100A6 whereby preventing the progression of EMS. +other 33197036 hsa-mir-23a Cardiomyopathies The present study investigated the effect of miRNA-23a-3p on cell proliferation and apoptosis in a myocardial injury model induced by high glucose. H9c2 cardiomyocytes were exposed to high glucose to establish an in vitro myocardial injury model and then transfected with miRNA-23a-3p mimics. +other 33197036 hsa-mir-23a Hyperglycemia However, the biological function of miRNA-23a in hyperglycemia-related cardiomyocyte injury is not fully understood. +genetics_overexpression_promote 33196969 hsa-mir-520a Carcinoma, Ovarian Epithelial Furthermore, overexpression of SUV39H1 reversed the suppressive effects of miR-520a-3p in EOC cells. +genetics_knock down_promote 33196911 hsa-mir-190 Ischemic Stroke Moreover, overexpression of miR-190 significantly downregulated the increased mRNA and protein expression of Rho/Rho kinase and cell apoptosis, while inhibition of miR-190 further upregulated the increased mRNA and protein expression of Rho/Rho kinase and cell apoptosis in rats suffering with I/R. +exosome 33196678 hsa-let-7g Fetal Alcohol Spectrum Disorders We also determined putative functional roles for AF exosomal miRNAs (miR-199a-3p, miR3p and let-7g) that are dysregulated by FAE in osteogenic differentiation of rBMSCs. +exosome 33196678 hsa-mir-214 Fetal Alcohol Spectrum Disorders We also determined putative functional roles for AF exosomal miRNAs (miR-199a-3p, miR3p and let-7g) that are dysregulated by FAE in osteogenic differentiation of rBMSCs. +exosome 33196678 hsa-mir-199a Fetal Alcohol Spectrum Disorders We also determined putative functional roles for AF exosomal miRNAs (miR-199a-3p, miR3p and let-7g) that are dysregulated by FAE in osteogenic differentiation of rBMSCs. +genetics_overexpression_promote 33195700 hsa-mir-122 Dehydration The study is aimed at investigating the role of microRNA-122 (miR-122) and oxidative stress on DVT. The results showed that miR-122 overexpression dampened H(2)O(2)-evoked cytotoxic injury in human umbilical vein endothelial cells (HUVECs) by increasing cell viability, suppressing cell apoptosis and oxidative stress injury. +other 33195700 hsa-mir-122 Venous Thrombosis The study is aimed at investigating the role of microRNA-122 (miR-122) and oxidative stress on DVT. +genetics_knock down_promote 33195697 hsa-mir-154 Carcinoma, Hepatocellular CONCLUSION: DLGAP1-AS2 knockdown may inhibit HCC cell migration and invasion by regulating miR +circRNA target 33195693 hsa-mir-514a Adrenocortical Carcinoma What is more, circ-CCAC1 enhanced C22orf46 expression by sponging miR-514a-5p in ACC cells. A rescue assay illustrated that circ-CCAC1 facilitated ACC progression through miR-514a-5p/C22orf46 signaling. +circulation_biomarker_diagnosis_ns 33195407 hsa-mir-96 Diabetes Mellitus, Type 2 In addition, we found that serum GAS5 levels were negatively correlated with the serum levels of miR-29a-3p, miR3p, and miR-208a-3p in patients with T2DM. +circulation_biomarker_diagnosis_ns 33195407 hsa-mir-208a Diabetes Mellitus, Type 2 In addition, we found that serum GAS5 levels were negatively correlated with the serum levels of miR-29a-3p, miR3p, and miR-208a-3p in patients with T2DM. +circulation_biomarker_diagnosis_ns 33195407 hsa-mir-29a Diabetes Mellitus, Type 2 In addition, we found that serum GAS5 levels were negatively correlated with the serum levels of miR-29a-3p, miR3p, and miR-208a-3p in patients with T2DM. +target gene 33195232 hsa-mir-663a Bronchopulmonary Dysplasia Promotion of Bronchopulmonary Dysplasia Progression Using Circular RNA circabcc4 via Facilitating PLA2G6 Expression by Sequestering miR-663a. +other 33195225 hsa-mir-182 Intervertebral Disc Degeneration 5p/FOXO3 pathway was an important underlying mechanism in the involvement of compression during the IDD progression. +transcription factor target 33195212 hsa-mir-432 Adenocarcinoma of Lung In addition, we also identified miR5p as a potential targeted molecule and bexarotene as a potential targeted drug of the three genes through bioinformatic analysis and further verified the anti-inflammatory effect of bexarotene, providing new ideas for the treatment of COVID-19. +transcription factor target 33195212 hsa-mir-432 COVID-19 In addition, we also identified miR5p as a potential targeted molecule and bexarotene as a potential targeted drug of the three genes through bioinformatic analysis and further verified the anti-inflammatory effect of bexarotene, providing new ideas for the treatment of COVID-19. +genetics_GWAS 33195195 hsa-mir-143 Anovulation These findings suggest that H3K27me3-mediated MIR143 inhibition play a critical role in follicular atresia by regulating cell apoptosis and steroidogenesis, which will provide useful information for further investigations of H3K27me3-miediated MIR143 epigenetic regulation in follicular growth in mammals. +other 33195183 hsa-mir-185 Prostatic Neoplasms The miR3p level showed a negative correlation with the circ_0088233 level in prostate cancer tissues. +circulation_biomarker_diagnosis_down 33194849 hsa-mir-100 Oral Ulcer Expression levels of NCK1-AS1 and miR-100 in plasma from both OSCC and OU patients were measured by RT-qPCR. CONCLUSIONS: Therefore, NCK1-AS1 may promote the metastasis of OSCC by downregulating miR-100. +circulation_biomarker_diagnosis_down 33194849 hsa-mir-100 Squamous Cell Carcinoma of Head and Neck Expression levels of NCK1-AS1 and miR-100 in plasma from both OSCC and OU patients were measured by RT-qPCR. CONCLUSIONS: Therefore, NCK1-AS1 may promote the metastasis of OSCC by downregulating miR-100. +transcription factor target 33194826 hsa-mir-1207 COVID-19 In summary, our results indicate that dysregulation of miR5p-target genes during SARS-CoV-2 infection may contribute to uncontrolled inflammation in most severe COVID-19 cases. +target gene 33194748 hsa-mir-7 Lymphoma, Non-Hodgkin MicroRNA-7 Regulates Migration and Chemoresistance in Non-Hodgkin Lymphoma Cells Through Regulation of KLF4 and YY1. +other 33194696 hsa-mir-21 Rectal Neoplasms Conclusion: miR-21 may predict response to CRT in rectal cancer (RC). +lncRNA target 33194664 hsa-mir-550a Adenocarcinoma of Lung This study aimed to explore the role of miR-550a-5p, a lung adenocarcinoma-associated mature microRNA screened out from the TCGA database via R-studio and Perl, with abundant expression in samples and with 5-year survival prognosis difference, as well as having not been studied in lung cancer yet. In summary, a new potential prognostic and therapeutic biomarker, miR-550a-5p, has been identified by bioinformatics analysis and experimental validation in vitro and in vivo, which promotes lung adenocarcinoma by silencing a known suppressor oncogene LIMD1. +transcription factor target 33194637 hsa-mir-1269a Glioma Taking the findings together, our study implies that the miR-1269a/ATRX axis is a novel therapeutic target of glioma. +transcription factor target 33194623 hsa-mir-574 Chordoma Bioinformatical analysis revealed an important regulatory role for miR3p/EGFR signaling in chordoma and showed that the target genes of these prognostic miRNAs were mainly enriched in transcription regulation, protein binding and cancer-related pathways. +epigenetics 33194611 hsa-mir-497 Breast Neoplasms Methylation-Mediated Silencing of MicroRNA-497 Promotes Breast Cancer Progression Through Up-Regulation of Mucin1. +other 33194594 hsa-mir-484 Colonic Neoplasms For example, KCNQ1OT1/miR-484/ANKRD36 axis was involved in the initiation of colon cancer, while KCNQ1OT1/miR-181a-5p/PCGF2 axis was implicated in the metastasis of rectal cancer; the SNHG1/miR-484/ORC6 axis played a role in colon cancer, while SNHG1/miR5p/EZH2 and SNHG1/let-7b-5p/ATP6V1F axes participated in the initiation and metastasis of rectal cancer, respectively. +other 33194594 hsa-mir-423 Colonic Neoplasms For example, KCNQ1OT1/miR-484/ANKRD36 axis was involved in the initiation of colon cancer, while KCNQ1OT1/miR-181a-5p/PCGF2 axis was implicated in the metastasis of rectal cancer; the SNHG1/miR-484/ORC6 axis played a role in colon cancer, while SNHG1/miR5p/EZH2 and SNHG1/let-7b-5p/ATP6V1F axes participated in the initiation and metastasis of rectal cancer, respectively. +other 33194594 hsa-mir-181a Colonic Neoplasms For example, KCNQ1OT1/miR-484/ANKRD36 axis was involved in the initiation of colon cancer, while KCNQ1OT1/miR-181a-5p/PCGF2 axis was implicated in the metastasis of rectal cancer; the SNHG1/miR-484/ORC6 axis played a role in colon cancer, while SNHG1/miR5p/EZH2 and SNHG1/let-7b-5p/ATP6V1F axes participated in the initiation and metastasis of rectal cancer, respectively. +other 33194594 hsa-let-7b Colonic Neoplasms For example, KCNQ1OT1/miR-484/ANKRD36 axis was involved in the initiation of colon cancer, while KCNQ1OT1/miR-181a-5p/PCGF2 axis was implicated in the metastasis of rectal cancer; the SNHG1/miR-484/ORC6 axis played a role in colon cancer, while SNHG1/miR5p/EZH2 and SNHG1/let-7b-5p/ATP6V1F axes participated in the initiation and metastasis of rectal cancer, respectively. +other 33194441 hsa-mir-21 Carcinoma, Renal Cell 5p was found to be an independent prognostic factor. +transcription factor target 33194382 hsa-mir-6026 paramyotonia congenita of Von Eulenburg Interestingly, one TomiRNA, miR6026, can target open reading frames from both viruses, i.e., the phosphoprotein encoding gene of PhCMoV, and the two replicase components of ToBRFV. +transcription factor target 33194382 hsa-mir-6026 Benign Paroxysmal Positional Vertigo Interestingly, one TomiRNA, miR6026, can target open reading frames from both viruses, i.e., the phosphoprotein encoding gene of PhCMoV, and the two replicase components of ToBRFV. +target gene 33194147 hsa-mir-155 Lymphoma, B-Cell Proliferation and Apoptosis of B-Cell Lymphoma Cells under Targeted Regulation of FOXO3 by miR-155. +other 33194081 hsa-mir-137 Carcinoma, Non-Small-Cell Lung Long non-coding RNA NCK1-AS1 promotes the proliferation, migration and invasion of non-small cell lung cancer cells by acting as a ceRNA of miR-137. +transcription factor target 33194051 hsa-mir-199a Ischemic Stroke Sprague-Dawley rats were divided into 6 groups: Normal group (normal rats), Sham group (rats received sham operation), Model group (MCAO rats), miR-199a-5p inhibitor group (model rats treated with miR-199a-5p inhibitor), IGF-1 group (model rats treated with AKT signaling pathway activator), miR-199a-5p inhibitor IGF-1 group (model rats treated by miR-199a-5p inhibitor and AKT signaling pathway activator). +genetics_overexpression_suppress 33194032 hsa-mir-24 Thyroid Neoplasms Overexpression of lncRNA CASC2 inhibits the tumorigenesis of thyroid cancer via sponging miR-24-3p. +genetics_overexpression_promote 33194029 hsa-mir-4644 Urinary Bladder Neoplasms UBIAD1 overexpression effectively abrogated the promoting effects of miR-4644 mimic on BCa proliferation, migration, and invasion. +target gene 33194025 hsa-mir-556 Triple Negative Breast Neoplasms Circular RNA circRPPH1 promotes triple-negative breast cancer progression via the miR-556-5p/YAP1 axis. +genetics_overexpression_promote 33194015 hsa-mir-16 Tuberculosis It is worth noting that the overexpression of miR-16 inhibits the expression of CD272 and B12 in monocytes of TB patients. +target gene 33193851 hsa-mir-216b Osteosarcoma Thiostrepton and miR-216b synergistically promote osteosarcoma cell cytotoxicity and apoptosis by targeting FoxM1. +target gene 33193850 hsa-mir-140 Lung Neoplasms Downregulated microRNA-140-5p expression regulates apoptosis, migration and invasion of lung cancer cells by targeting zinc finger protein 800. +lncRNA target 33193848 hsa-mir-431 Carcinoma, Hepatocellular In conclusion, circ_0008450 repression mitigated the progression of HCC under hypoxia by downregulating AKAP1 via miR-431, providing a potential target for HCC treatment. +target gene 33193846 hsa-mir-623 Breast Neoplasms MicroRNA-623 inhibits tumor progression and is a predictor of poor prognosis of breast cancer. +other 33193844 hsa-mir-342 Cardiovascular Diseases Studies have shown that microRNA(miR)5p participates in the development of cardiovascular diseases. +genetics_knock down_promote 33193757 hsa-mir-21 Esophageal Squamous Cell Carcinoma In conclusion, the aberrant overexpression of miR-21 is common in cancer and promotes the migration and invasion of ESCC through inhibiting the TPM1 expression. +transcription factor target 33193717 hsa-mir-22 Benign Paroxysmal Positional Vertigo Conclusively, this study provides new insight into miRNAs regulating genes responding to BCoV infection, with bta-miR3p particularly indicated as a potential drug target or diagnostic marker for bovine coronavirus. +lncRNA target 33193697 hsa-mir-654 Colorectal Neoplasms 3p significantly suppressed the proliferation and migration capacity of CRC cells by enhancing apoptosis and promoting G0/G1 phase arrest. +lncRNA target 33193658 hsa-mir-489 Colorectal Neoplasms 3p axis might provide potential therapeutic targets against CRC metastasis. +other 33193605 hsa-mir-22 Cholangiocarcinoma CONCLUSION: Based on the survival analysis, we conclude that DEPDC1, FUT4, MDK, PACS1, PIWIL4 genes, miR-22, miR-551b microRNAs, and cg27362525 and cg26597242 CpGs can strongly support their use as prognostic markers of CCA. +other 33193605 hsa-mir-551b Cholangiocarcinoma CONCLUSION: Based on the survival analysis, we conclude that DEPDC1, FUT4, MDK, PACS1, PIWIL4 genes, miR-22, miR-551b microRNAs, and cg27362525 and cg26597242 CpGs can strongly support their use as prognostic markers of CCA. +genetics_knock down_promote 33193573 hsa-mir-219-1 Adenocarcinoma of Lung In vivo, knockdown of CCAT1 suppressed the tumor growth of LAD xenografts, which were rescued by the inhibition of miR +lncRNA target 33193424 hsa-mir-146a Wounds and Injuries Nanosilk solution is able to strengthen the biomechanical properties of diabetic skin and can successfully deliver CNP-miR146a to improve diabetic wound healing through inhibition of pro-inflammatory gene signaling and promotion of pro-fibrotic processes. +lncRNA target 33193424 hsa-mir-146a Diabetes Mellitus, Type 2 Nanosilk solution is able to strengthen the biomechanical properties of diabetic skin and can successfully deliver CNP-miR146a to improve diabetic wound healing through inhibition of pro-inflammatory gene signaling and promotion of pro-fibrotic processes. +transcription factor target 33192625 hsa-mir-19b Depressive Disorder miR-19b3p was predicted to be involved in the pathway of inflammatory dysregulation associated with experiencing early childhood trauma. +transcription factor target 33192625 hsa-mir-19b Bipolar Disorder miR-19b3p was predicted to be involved in the pathway of inflammatory dysregulation associated with experiencing early childhood trauma. +other 33192550 hsa-mir-23a Norrie disease CONCLUSION: Overall, our study identified the LXRs/LncOR13C9/miR23A-5p/ABCA1 regulatory network in GEnCs, which may be helpful to better understand the effect of HG on cholesterol accumulation in GEnCs under cholesterol load and to explore new therapeutic tools for the management of DN patients. +other 33192537 hsa-mir-146a Inflammation Conclusion: A non-canonical positive feedback interaction between miR-146a-5p and OGT is involved in a vicious cycle to aggravate HG-induced vascular complications. +other 33192260 hsa-mir-146a Cerebral Hemorrhage Our results demonstrated that the phosphatidylinositol 3-kinase (PI3K)/AKT pathway participated in the GHK-induced upregulation of miR-146a-3p and miR-146a-3p/AQP4 interaction plays a role in the injury following ICH. +lncRNA target 33192200 hsa-mir-152 Osteoarthritis CONCLUSION: Present study concludes miR-152 diminished the progression of osteoarthritis partially by inhibiting the expression of TCF-4. +lncRNA target 33192200 hsa-mir-152 Cartilage Diseases CONCLUSION: Present study concludes miR-152 diminished the progression of osteoarthritis partially by inhibiting the expression of TCF-4. +genetics_overexpression_promote 33192097 hsa-mir-26b Triple Negative Breast Neoplasms CONCLUSION: Therefore, overexpression of TATDN1 promotes cancer cell proliferation in TNBC by regulating the methylation of miR-26b gene. +genetics_GWAS 33192092 hsa-mir-636 Multiple Myeloma Circ_0069767 by sponging miR-636 in MM cells regulates the expression of K-RAS while the K-RAS gene remained unmutated. +target gene 33192091 hsa-mir-16 Glioma Tanshinone IIA Suppresses Glioma Cell Proliferation, Migration and Invasion Both in vitro and in vivo Partially Through miR-16-5p/Talin-1 (TLN1) Axis. +genetics_knock down_suppress 33192077 hsa-mir-299 Stomach Neoplasms Circ_0110805 Knockdown Enhances Cisplatin Sensitivity and Inhibits Gastric Cancer Progression by miR-299-3p/ENDOPDI Axis. +genetics_overexpression_promote 33192074 hsa-mir-101 Esophageal Squamous Cell Carcinoma 3p overexpression on cell apoptosis in ESCC cells. +other 33191875 hsa-mir-100 Precursor Cell Lymphoblastic Leukemia-Lymphoma miR-100 is a useful prognostic and predictive biomarker for childhood ALL. +genetics_knock down_promote 33191714 hsa-mir-27b Squamous Cell Carcinoma of Head and Neck Downregulation of miR-27b-3p partially reversed the tumor suppression effect and CDDP chemosensitivity of XIST knockdown in CDDP-resistant OSCC cells. +lncRNA target 33191397 hsa-mir-449b Adenocarcinoma of Lung Altogether, ZEB1-activated LINC01123 accelerates the malignancy in LUAD through miR-449b-5p/NOTCH1 axis-mediated NOTCH signaling pathway, while NOTCH1 boosts ZEB1 in return. +transcription factor target 33191361 hsa-mir-24 Atrial Fibrillation 3p directly targeted transforming growth factor beta1 in fibroblast, which may be involved in the development of myocardial fibrosis during AF. +lncRNA target 33191336 hsa-mir-24 Myocardial Infarction MiR-324/SOCS3 axis could improve the H/R-induced injury of cardiomyocytes via regulating TNF/NF-kappaB signaling pathway, and this might provide a new therapy strategy for myocardial ischemia. +lncRNA target 33191176 hsa-mir-296 Arthritis, Rheumatoid 5p-dependent inhibition of MMP-15. +genetics_overexpression_promote 33191095 hsa-mir-21 Opitz GBBB Syndrome, X-Linked CONCLUSION: MiR-21 overexpression in OSF may be due to the stimulation of areca nut, which was mediated by the TGF-beta pathway. +other 33191002 hsa-mir-155 Marek Disease Similar to the oncogenic gamma-herpesvirus Kaposi's sarcoma-associated herpesvirus (KSHV), miR-M4-5p, the cellular microRNA-155 (miR-155) ortholog encoded by MDV-1, is also involved in MD oncogenesis. Our data presents a novel insight in elucidating the regulatory mechanisms mediated by the viral analog of miR-155 that potentially contribute to MD tumorigenesis. +virus_miRNA 33191002 kshv-mir-M4 Marek Disease mir-M4-5p has been shown to be highly expressed and participate in inducing MD lymphomagenesis by regulating multiple signal pathways. +genetics_GWAS 33190845 hsa-mir-214 Depression Genetic and pharmacological approaches were used to investigate the role of the TWIST1-miRPPAR-delta signaling pathway in depressive-like behaviors. +circulation_biomarker_diagnosis_ns 33190783 hsa-mir-128 Hypercholesterolemia 3p inhibition in lowering serum cholesterol and suggest its potential therapeutic implications in reversing hypercholesterolemia. +exosome 33190594 hsa-mir-22 Uterine Cervical Neoplasms Taken together, these results suggest that the administration of exosomal miR-22 may be a novel drug delivery system for cervical cancer radiotherapy. +circRNA target 33190405 hsa-mir-558 Lung Neoplasms In conclusion, our data support that hsa_circ_0030998 can slow down the progression of lung cancer by targeting miR-558 and suppress malignant phenotypes such as proliferation, migration, and invasion progression of lung cancer cells. +other 33190281 hsa-mir-34b Alcoholism RESULTS: Higher expressions of miR-34a and miR-34c, but not of miR-34b, were found in the group with AUD in comparison with the group without AUD after adjustment for potential confounders (age, sex, body mass index, presence of hypertension, diabetes mellitus, smoking, and physical inactivity). +other 33190281 hsa-mir-34c Alcoholism CONCLUSIONS: Hippocampal upregulation of miR-34a and miR-34c may be involved in the cognitive decline associated with chronic alcohol consumption. +other 33190281 hsa-mir-34a Alcoholism CONCLUSIONS: Hippocampal upregulation of miR-34a and miR-34c may be involved in the cognitive decline associated with chronic alcohol consumption. +circulation_biomarker_diagnosis_ns 33190168 hsa-mir-143 Dermatitis, Atopic In this study, we found that miR-143 was lowly expressed whereas IL-13Ralpha1 was highly expressed in blood cells of patients with AD, indicating their negative correlation. These findings revealed that the protective effects and the underlying mechanisms of CYT387 in AD, which provided evidence that miR-143 may be a novel therapeutic target for AD. +genetics_overexpression_promote 33190006 hsa-mir-582 Osteoarthritis The results showed that YAP1 overexpression can recover the effects induced by injection of AAV-miR +transcription factor target 33189894 hsa-mir-7844 Neurodegenerative Diseases Furthermore, for the first time we demonstrate that previously unknown miR5p targets mRNAs known to be involved in mitochondrial apoptosis, autophagy regulation, mood disorders, and neurodegenerative disease. +transcription factor target 33189818 hsa-mir-27a Melanoma SIGNIFICANCE: ISL inhibits proliferation and metastasis of melanoma via the miR-27a/POU2F3/c-MYC/p53 axis; these results may provide a new thought for the treatment of melanoma. +other 33189795 hsa-mir-218 Esophageal Neoplasms A negative correlation was found between miR-218 and GAB2 mRNA expression in esophageal cancer patients and control people. +lncRNA target 33189612 hsa-mir-7a Inflammation Our study thus demonstrates Meg3 regulates microglia inflammation by targeting the miR-7a-5p /Nlrp3 pathway. +other 33189302 hsa-mir-186 Neuroblastoma LncRNA HCP5 promotes neuroblastoma proliferation by regulating miR-186-5p/MAP3K2 signal axis. +genetics_overexpression_promote 33188837 hsa-mir-548b Thyroid Cancer, Papillary KPNA4 overexpression abrogated the suppression of miR-548b-3p on the malignant phenotypes of PTC cells. +genetics_overexpression_suppress 33188660 hsa-mir-136 Venous Thrombosis Conjointly, our data indicate that the overexpression of miR +genetics_knock down_promote 33188501 hsa-mir-370 Glioma Circ-VPS18 knockdown improved TMZ sensitivity and repressed glioma progression by sponging miR-370 to downregulate RUNX1 expression, which provided a new insight in further studying glioma resistance to TMZ. +other 33188287 hsa-mir-200 Ovarian Neoplasms Collectively, these findings highlight the reciprocal network that integrates ET(A)R and ZEB1 axes with the miR-200b/c regulatory circuit to favour metastatic progression in ovarian cancer. +other 33188287 hsa-mir-200b Ovarian Neoplasms Collectively, these findings highlight the reciprocal network that integrates ET(A)R and ZEB1 axes with the miR-200b/c regulatory circuit to favour metastatic progression in ovarian cancer. +other 33187583 hsa-mir-21 Colonic Neoplasms The purpose of this study is to reveal the potential impact of miR5p on the occurrence process of CRC and its connection with a close homolog of L1 (CHL1). +other 33187583 hsa-mir-151 Colonic Neoplasms In this study, the expression level of the miR3p was found to be significantly higher in colon adenocarcinoma tissue compared with adjacent normal tissues, while the CHL1 was lower in colon adenocarcinoma tissues. +genetics_overexpression_promote 33187481 hsa-mir-212 Breast Neoplasms 3p overexpression. +lncRNA target 33187014 hsa-mir-101a Temporomandibular Joint Osteoarthritis CONCLUSION: Our results suggested that miR-101a-3p was involved in the pathogenesis of TMJOA and that its mechanism was probably interaction with its target genes UBE2D1 and FZD4. +transcription factor target 33186919 hsa-mir-205 Cicatrix, Hypertrophic Compared to the control group, miR-205 inhibited hypertrophic scar development. +transcription factor target 33186708 hsa-mir-15a Necrosis Overall, we conclude that RSV could relieve CT-induced apoptosis and necroptosis through miR-15a/Bcl2-A20 axis in CIK cells. +lncRNA target 33186139 hsa-mir-498 Carcinoma, Non-Small-Cell Lung Circ-ZNF124 downregulation inhibits non-small cell lung cancer progression partly by inactivating the Wnt/-catenin signaling pathway via mediating the miR-498/YES1 axis. In conclusion, these findings supported that circ-ZNF124 regulated the expression of YES1 by acting as a sponge of miR-498, thus restraining NSCLC development by inactivating the Wnt/-catenin signaling pathway, which provided a novel strategy to treat NSCLC. +other 33186123 hsa-mir-20 Non-alcoholic Fatty Liver Disease Moreover, we tested whether miR-320, a miRNA promoting lipid accumulation in heart revealed by our previous study, also participated in NAFLD. +exosome 33185898 hsa-mir-150 Peri-Implantitis BACKGROUND: To explore the diagnostic usefulness of extracellular vesicles (EVs), and their subpopulations (micro-vesicles and exosomes), and microRNAs (miRNA +exosome 33185898 hsa-mir-21 Peri-Implantitis BACKGROUND: To explore the diagnostic usefulness of extracellular vesicles (EVs), and their subpopulations (micro-vesicles and exosomes), and microRNAs (miRNA +circulation_biomarker_diagnosis_up 33185814 hsa-mir-146a Alzheimer Disease Because miR-146a plays a predominant role in inducing TLR tolerance in macrophages and because miR-146a in extracellular vesicles (EVs) shed by inflammatory macrophages increases in circulation, we investigated potential roles of miR-146a and inflammatory EVs in inducing TLR tolerance in microglia and in altering expression of inflammatory AD risk genes. We found that miR-146a upregulation induces TLR tolerance and alters expression of inflammatory AD risk genes in response to LPS treatment in BV2 microglia. +genetics_overexpression_suppress 33185692 hsa-mir-589 Carcinoma, Renal Cell Finally, overexpressed CBX5 or inhibited miR +genetics_overexpression_suppress 33185588 hsa-mir-802 Uterine Cervical Neoplasms Overexpression of MYLIP eliminated the inhibitory effects of miR-802 on growth and metastatic-related traits of cervical cancer cell. +genetics_overexpression_promote 33185386 hsa-mir-145 Diabetic Neuropathies CONCLUSION: Early infection with a lentiviral vector overexpressing miR-145 adversely regulated the expression and function of TTX-resistant Nav1.8 and abrogated the development of PDN. +genetics_overexpression_promote 33185386 hsa-mir-145 Diabetes Mellitus, Type 2 CONCLUSION: Early infection with a lentiviral vector overexpressing miR-145 adversely regulated the expression and function of TTX-resistant Nav1.8 and abrogated the development of PDN. +genetics_overexpression_promote 33185125 hsa-mir-146a Acute Lung Injury SIRT1-overexpressing or miR-146a-3p-underexpressing up-regulated NF-kappaB expression, promoted viability and inhibited apoptosis of LPS-induced BEAS-2B cells in vitro, and increased NF-kappaB expression, down-regulated the W/D ratio, attenuated pathological changes, suppressed apoptosis, and alleviated inflammatory response and oxidative stress in the lung of ALI rats. +lncRNA target 33184989 hsa-mir-1287 Pancreatic Carcinoma Our data reveal that the circ_0075829 could facilitate the proliferation and metastasis of PC through circ_0075829/miR +transcription factor target 33183906 hsa-mir-24 Alopecia CONCLUSION: Together, we offer a platform for understanding miRNA dynamic regulation in follicular stem and progenitor cells in baldness and highlight miR3p as a promising target for its treatment. +other 33183484 hsa-mir-195 Sepsis The study results of this paper provide a reference for further research on the efficacy of nanoantibiotics in sepsis rats based on MicroRNA-195 and TGF-beta1/Smads signaling pathway. +lncRNA target 33183350 hsa-mir-96 Colorectal Neoplasms CONCLUSIONS: Taken together, miR-96 antagomir could potentially retard the cancerogenesis in CRC via AMPKalpha2-dependent inhibition of FTO and blocking FTO-mediated m6A modification of MYC, highlighting novel mechanisms associated with colorectal cancerogenesis. +transcription factor target 33183243 hsa-mir-183 Amnesia CONCLUSION: In summary, the findings of this study demonstrated that scopolamine-induced amnesia was associated with downregulated expression of miR-210/miR-183 and upregulated expression of SIN3A. Furthermore, treatment with EA alleviated scopolamine-induced amnesia in rats and was associated with upregulated expression of miR-210/miR-183 and downregulated expression of SIN3A. +transcription factor target 33183243 hsa-mir-210 Amnesia CONCLUSION: In summary, the findings of this study demonstrated that scopolamine-induced amnesia was associated with downregulated expression of miR-210/miR-183 and upregulated expression of SIN3A. Furthermore, treatment with EA alleviated scopolamine-induced amnesia in rats and was associated with upregulated expression of miR-210/miR-183 and downregulated expression of SIN3A. +other 33182505 hsa-mir-342 Cardiovascular Diseases 3p) induced microRNA upregulation in children affected with pregnancy complications. +other 33182505 hsa-mir-92a Obesity 3p) induced microRNA upregulation in children affected with pregnancy complications. +other 33182505 hsa-mir-342 Heart Valve Diseases 3p) induced microRNA upregulation in children affected with pregnancy complications. +other 33182505 hsa-mir-92a Hypertension 3p) induced microRNA upregulation in children affected with pregnancy complications. +other 33182505 hsa-mir-342 Heart Defects, Congenital 3p) induced microRNA upregulation in children affected with pregnancy complications. +other 33182505 hsa-mir-342 Peripheral Blood Leukocytes 3p) induced microRNA upregulation in children affected with pregnancy complications. +other 33182505 hsa-mir-92a Prehypertension 3p) induced microRNA upregulation in children affected with pregnancy complications. +other 33182505 hsa-mir-92a Cardiovascular Diseases 3p) induced microRNA upregulation in children affected with pregnancy complications. +other 33182505 hsa-mir-92a Heart Defects, Congenital 3p) induced microRNA upregulation in children affected with pregnancy complications. +other 33182505 hsa-mir-342 Obesity 3p) induced microRNA upregulation in children affected with pregnancy complications. +other 33182505 hsa-mir-210 Peripheral Blood Leukocytes 3p) induced microRNA upregulation in children affected with pregnancy complications. +other 33182505 hsa-mir-342 Hypertension 3p) induced microRNA upregulation in children affected with pregnancy complications. +other 33182505 hsa-mir-342 Prehypertension 3p) induced microRNA upregulation in children affected with pregnancy complications. +other 33182505 hsa-mir-210 Heart Defects, Congenital 3p) induced microRNA upregulation in children affected with pregnancy complications. +other 33182505 hsa-mir-210 Cardiovascular Diseases 3p) induced microRNA upregulation in children affected with pregnancy complications. +other 33182505 hsa-mir-92a Peripheral Blood Leukocytes 3p) induced microRNA upregulation in children affected with pregnancy complications. +other 33182505 hsa-mir-210 Heart Valve Diseases 3p) induced microRNA upregulation in children affected with pregnancy complications. +other 33182505 hsa-mir-210 Obesity 3p) induced microRNA upregulation in children affected with pregnancy complications. +other 33182505 hsa-mir-210 Hypertension 3p) induced microRNA upregulation in children affected with pregnancy complications. +other 33182505 hsa-mir-210 Prehypertension 3p) induced microRNA upregulation in children affected with pregnancy complications. +other 33182505 hsa-mir-92a Heart Valve Diseases 3p) induced microRNA upregulation in children affected with pregnancy complications. +other 33182065 hsa-mir-195 Inflammatory Bowel Diseases 5p, providing an alternative for diagnosis and treatment of UC. +other 33182065 hsa-mir-16 Inflammatory Bowel Diseases 5p, providing an alternative for diagnosis and treatment of UC. +exosome 33182030 hsa-mir-153 Cryopyrin-Associated Periodic Syndromes CONCLUSIONS: This study outlines the role of decidual macrophage-derived exosomal miR +other 33181653 hsa-mir-153 Breast Neoplasms Subgroup analysis found that low miR-153 expression was associated with worse OS in the reported directly from articles group (HR = 2.67, 95% CI: 1.32-5.37, P = .006), survival curves group (HR = 2.10, 95% CI: 1.56-2.84, P < .001), digestive system tumor (HR = 2.76, 95% CI: 1.73-4.41, P < .001), and breast cancer (HR = 4.01, 95% CI: 1.46-11.04, P = .007).Moreover, cancer patients with low miR-153 expression were prone to poor tumor differentiation(poor vs well+moderate, OR = 2.41, 95% CI = 1.52-3.82, P < .001), earlier lymph node metastasis (present vs absent, OR = 2.19, 95% CI = 1.12-4.25, P = .021) and earlier distant metastasis (present vs absent,OR = 8.24, 95% CI = 2.93-23.21, P < .001), but not associated with age,gender and TNM stage. miR-153 may serve as an effective predictive biomarker for tumor prognosis, especially for digestive system tumor and breast cancer. +other 33181653 hsa-mir-153 Digestive System Neoplasms Subgroup analysis found that low miR-153 expression was associated with worse OS in the reported directly from articles group (HR = 2.67, 95% CI: 1.32-5.37, P = .006), survival curves group (HR = 2.10, 95% CI: 1.56-2.84, P < .001), digestive system tumor (HR = 2.76, 95% CI: 1.73-4.41, P < .001), and breast cancer (HR = 4.01, 95% CI: 1.46-11.04, P = .007).Moreover, cancer patients with low miR-153 expression were prone to poor tumor differentiation(poor vs well+moderate, OR = 2.41, 95% CI = 1.52-3.82, P < .001), earlier lymph node metastasis (present vs absent, OR = 2.19, 95% CI = 1.12-4.25, P = .021) and earlier distant metastasis (present vs absent,OR = 8.24, 95% CI = 2.93-23.21, P < .001), but not associated with age,gender and TNM stage. miR-153 may serve as an effective predictive biomarker for tumor prognosis, especially for digestive system tumor and breast cancer. +exosome 33181174 hsa-mir-5100 Breast Neoplasms MiR-5100 of PGRN(-/-) TAMs-derived exosomes was up-regulated, which might regulate expression of CXCL12, thereby inhibiting the CXCL12/CXCR4 axis, and ultimately inhibiting the invasion, migration and EMT of breast cancer cells. +lncRNA target 33181172 hsa-mir-150 Sepsis SIGNIFICANCE: Our findings suggest that miR-150 affects sepsis-induced endothelial injury by regulating ER stress and inflammation via MALAT1-mediated NF-kappaB pathway. +circulation_biomarker_diagnosis_up 33180826 hsa-mir-92a Liver Diseases GIFT injected in the tail vein with an miR-92a agomir showed up-regulation of miR-92a and down-regulation of CaSR, p53, TP53INP1, and caspase-3/8 genes in the liver, resulting in lower serum aspartate aminotransferase and alanine aminotransferase activities under hypoxia stress. +lncRNA target 33180658 hsa-mir-382 Liver Neoplasms 3p directly targeted CYP2C8 to inhibit its expression in liver cancer cells based on bioinformatic prediction and experimental confirmation. +transcription factor target 33180568 hsa-mir-15b Death, Sudden, Cardiac Luciferase activity assay indicated that COX10 expression could be regulated by rs397763766 through interfering binding with miR-15b, thus conferring risk of SCD. +other 33180258 hsa-mir-150 Alzheimer Disease Also, the found miR-150 precursor had AD-specific miRNA-imbalance characteristics. +exosome 33179861 hsa-let-7d Pulmonary Fibrosis Exosomes with low let-7d from pulmonary vascular endothelial cells drive lung pericyte fibrosis through activating the TGFbetaRI/FoxM1/Smad/beta-catenin signalling pathway. +lncRNA target 33179755 hsa-mir-513b Uterine Cervical Neoplasms Furthermore, LINC00861 was suggested to serve as a competing endogenous RNA by sponging miR513b5p and consequently upregulating the expression levels of PTEN in cervical cancer cells. In conclusion, the findings of the present study indicated that the LINC00861/miR513b5p axis may inhibit the progression of cervical cancer cells through the PTEN/AKT/mTOR signaling pathway to suppress the EMT process. +lncRNA target 33179372 hsa-mir-485 Osteoporosis-pseudoglioma syndrome CONCLUSIONS: SNHG16 promotes the osteogenic differentiation of hBMSCs via regulating the miR5p/BMP7 axis and comprises a prospective therapy target for OP. +lncRNA target 33179318 hsa-mir-497 Carcinoma, Non-Small-Cell Lung Taken together, our findings indicate that KRT17P3/miR5p/mTOR regulates the chemosensitivity of NSCLC, suggesting a potential therapeutic target for cisplatin-resistant NSCLC patients. +transcription factor target 33179210 hsa-mir-421 Neurotoxicity Syndromes Inhibition of miR-421 or restoration of MEF2D protected neurons from neurotoxicity in cellular and animal models of PD. +transcription factor target 33179210 hsa-mir-421 Parkinson Disease Inhibition of miR-421 or restoration of MEF2D protected neurons from neurotoxicity in cellular and animal models of PD. +transcription factor target 33179116 hsa-mir-1 Rhinitis, Allergic The expression levels of miR31 were significantly decreased in the nasal mucosa of the AR group compared with those in the control group. In conclusion, these data revealed that miR31 could ameliorate AR by suppressing IL13induced nasal epithelial inflammatory responses, and thus may serve as a novel therapeutic target for AR. +genetics_knock down_promote 33179110 hsa-mir-495 Colorectal Neoplasms Rescue assays indicated that miR495 inhibitor reversed the suppressive effects of SNHG20 knockdown on CRC progression. +transcription factor target 33179108 hsa-mir-140 Carcinoma, Hepatocellular Following inhibition of miR1405p expression, the proliferation, invasion and migration of HCC cells were promoted, Ecadherin expression was decreased, and the levels of vimentin and Ncadherin were increased. Thus, the results suggested that the antitumor potential of catalpol in HCC may be exerted by regulating the expression of miR1405p to inhibit proliferation, invasion, migration and EMT of HCC cells. +genetics_knock down_promote 33179106 hsa-mir-93 Triple Negative Breast Neoplasms The present study investigated the association between miR93, epithelialtomesenchymal transition (EMT) and VM formation in TNBC cell lines. VM formation assay showed a significant decrease in microtubuleforming ability of cells following miR93 knockdown, which was associated with the occurrence of EMT, suggesting that miR93 may promote the formation of VM via EMT and may be a therapeutic target for the treatment of TNBC. +transcription factor target 33179102 hsa-mir-449a Cardiomyopathies In conclusion, miR449a5p inhibited CM proliferation by targeting CDK6, which provides a potential molecular target for preventing myocardial injury. +lncRNA target 33179096 hsa-mir-211 Triple Negative Breast Neoplasms In conclusion, the findings from the present study demonstrated that TTNAS1 regulated the proliferation and invasive and migratory abilities of TNBC by targeting miR2115p. +transcription factor target 33179091 hsa-mir-125b Sjogren's Syndrome The results indicated that the expression levels of miRNA125b5p and miRNA155 in TCRactivated CD4(+) T cells from patients with pSS may provide insight regarding autoimmune diseases and offer a novel target for prospective treatment. +transcription factor target 33179091 hsa-mir-155 Sjogren's Syndrome The results indicated that the expression levels of miRNA125b5p and miRNA155 in TCRactivated CD4(+) T cells from patients with pSS may provide insight regarding autoimmune diseases and offer a novel target for prospective treatment. +other 33179089 hsa-mir-424 Obesity In the present study, miR424 expression levels were analyzed during adipogenesis and the differential expression of this miRNA in the adipose tissue of obese and nonobese children was also assessed. The results revealed that the expression levels of miR424 upregulated in the adipose tissue biopsies from obese children compared with the biopsies of nonobese children. +genetics_overexpression_promote 33179084 hsa-mir-218 Lung Neoplasms The results demonstrated that miR218 might serve a vital role in tumorigenesis and progression of Xuanwei lung cancer and overexpression of miR218 may be a novel approach for the treatment of Xuanwei lung cancer. +other 33178874 hsa-mir-372 Carcinoma, Hepatocellular However, miR-372 cannot be considered as a reliable marker as HULC for early detection of HCC especially in HCV patients. +lncRNA target 33178832 hsa-mir-205 Prostatic Neoplasms Conclusion miRNA-205 may play a vital role in PCa tumorigenesis and bone metastasis by targeting CDK1. +other 33178707 hsa-mir-185 Sarcoidosis, Pulmonary 5p in the lymph nodes can be used as an auxiliary marker for the differential diagnosis of sarcoidosis and tuberculous lymphadenitis. +genetics_knock down_promote 33178684 hsa-mir-432 Colorectal Neoplasms 3p in CRC, showing that the inhibitory effect of AC010789.1 knockdown on CRC cells was achieved by the upregulation of miR +exosome 33178588 hsa-mir-125b Carcinoma, Non-Small-Cell Lung RESULTS: A total of differential 22 miRNAs were screened out based on P < 0.05 and fold difference>2.0 by miRNA microarrays, among which, exosomal miR-5684 and miR-125b-5p were significantly down-regulated in NSCLC patients compared to healthy donors, processing favorable diagnostic efficiency for (early) NSCLC. CONCLUSION: Exosomal miR-5684 and miR-125b-5p levels are significantly down-regulated in NSCLC patients, and serve as the promising diagnostic and prognostic biomarkers for NSCLC. +other 33178582 hsa-mir-10b Hepatitis B, Chronic We further illuminated the anti-tumor role and mechanism of CHST4 in HBV-HCC by constructing a FENDRR-miR-10b-5p-CHST4 competing endogenous RNA network. +genetics_knock down_promote 33178353 hsa-mir-208a Osteosarcoma miR-208a-3p overexpression promoted and miR-208a-3p knockdown inhibited OS cells proliferation and metastatic potential. +other 33178345 hsa-mir-122 Prostatic Neoplasms MicroRNA-122 regulates docetaxel resistance of prostate cancer cells by regulating PKM2. +lncRNA target 33178344 hsa-mir-365 Diabetic Retinopathy Therefore, it was speculated that RPSAP52 may upregulate Timp3 by serving as the endogenous sponge of miR-365 in DR to suppress RPE cell apoptosis. +other 33178319 hsa-mir-654 Hepatitis B, Chronic 3p were confirmed as upregulated in CHB-liver fibrosis patients compared to CHB patients without fibrosis, whereas the other 4 miRNAs were not significantly different. +other 33178319 hsa-mir-654 Liver Cirrhosis 3p were confirmed as upregulated in CHB-liver fibrosis patients compared to CHB patients without fibrosis, whereas the other 4 miRNAs were not significantly different. +other 33178319 hsa-mir-144 Liver Cirrhosis 3p were confirmed as upregulated in CHB-liver fibrosis patients compared to CHB patients without fibrosis, whereas the other 4 miRNAs were not significantly different. +other 33178319 hsa-mir-144 Hepatitis B, Chronic 3p were confirmed as upregulated in CHB-liver fibrosis patients compared to CHB patients without fibrosis, whereas the other 4 miRNAs were not significantly different. +genetics_knock down_promote 33177878 hsa-mir-142 Carcinoma, Hepatocellular 3p inhibitor repressed cell proliferation, migration, invasion and cell cycle in HCC cells, while its effects were abolished by Bach-1 knockdown. +circRNA target 33177876 hsa-mir-125 Colorectal Neoplasms 5p targeted Musashi1 (MSI1) to increase the susceptibility of 5-fluorouracil and oxaliplatin in FOLFOX-resistant CRC cells. +genetics_knock down_promote 33177875 hsa-mir-593 Breast Neoplasms 3p overexpression hindered BC cell malignant progression in vitro by down-regulating FGFR3. +genetics_overexpression_promote 33177873 hsa-mir-802 Colorectal Neoplasms Moreover, upregulation of UBN2 expression could reverse the biological effects of CRC cells induced by miR-802 overexpression. +genetics_knock down_promote 33177842 hsa-mir-1231 Pancreatic Neoplasms Knockdown of lncRNA ABHD11-AS1 Suppresses the Tumorigenesis of Pancreatic Cancer via Sponging miR-1231. +genetics_knock down_promote 33177840 hsa-mir-216a Carcinoma, Non-Small-Cell Lung CONCLUSION: Knockdown of SNHG3 inhibits NSCLC tumour development and progression by upregulation of ZEB1 and interference with miR-216a, revealing an attractive alternative target for patients with NSCLC. +target gene 33177837 hsa-mir-515 Prostatic Neoplasms Circ_0057553/miR-515-5p Regulates Prostate Cancer Cell Proliferation, Apoptosis, Migration, Invasion and Aerobic Glycolysis by Targeting YES1. +target gene 33177835 hsa-mir-455 Squamous Cell Carcinoma of Head and Neck LncRNA XIST Inhibits the Progression of Oral Squamous Cell Carcinoma via Sponging miR-455-3p/BTG2 Axis. +transcription factor target 33177704 hsa-mir-99a Breast Neoplasms A total of 113 genes were identified as targets of pre-miR-99a regulation (19 genes modulated by miR-99a-5p, and 95 genes regulated by miR-99a-3p) in BrCa cells. +other 33177501 hsa-let-7 Lung Neoplasms We show that downregulation of let-7 correlates with accumulation of L1 insertions in human lung cancer. +lncRNA target 33177288 hsa-mir-4491 Carcinoma, Non-Small-Cell Lung These findings demonstrate that circ-BIRC6 functions as a critical regulator of proliferation and apoptosis via binding to and negatively regulating miR-4491, suggesting that circ-BIRC6 might be a potential target for treatment of NSCLC. +epigenetics 33177241 hsa-mir-29b Osteoarthritis Hypermethylation of specific CpG sites in the miR-29b promoter region induced by DNMT3B contributed to downregulation of miR-29b in OA chondrocytes. +lncRNA target 33177182 hsa-mir-183 Ganglion Cysts To test this hypothesis and develop an approach to eliminate DRG toxicity, we exploited endogenous expression of microRNA (miR) 183 complex, which is largely restricted to DRG neurons, to specifically down-regulate transgene expression in these cells. However, including miR183 targets in the vectors reduced transgene expression in, and toxicity of, DRG neurons without affecting transduction elsewhere in the primate's brain. +other 33177098 hsa-mir-519c Pancreatic Neoplasms Redox-responsive nanoplatform for codelivery of miR-519c and gemcitabine for pancreatic cancer therapy. +genetics_knock down_promote 33177072 hsa-mir-485 Uterine Cervical Neoplasms Overexpression of circHIPK3 triggered the upregulation of FGF2 expression while knockdown of circHIPK3 reduced FGF2 expression in CC cells, and the transfection of miR3p mimics reversed the upregulation of FGF2 expression and enhanced malignant phenotypes in CC cells with overexpressed circHIPK3. +circulation_biomarker_diagnosis_up 33176966 hsa-mir-21 Vitiligo METHODS: We measured serum levels of miR +other 33176720 hsa-mir-503 Hypertension, Renal Finally, insulin signaling pathway was screened to directly associate with HTN and was regulated by mRNAs PPP1R3C, PPKAR2B and AKT3, miRNA has-miR-107, and lncRNAs SNHG14, TUG1, ZNF252P-AS1 and MIR503HG. CONCLUSIONS: Insulin signaling pathway was directly associated with HTN, and miRNA has-miR-107 and lncRNAs SNHG14, TUG1, ZNF252P-AS1 and MIR503HG were the biomarkers of HTN. +other 33176720 hsa-mir-107 Hypertension, Renal Finally, insulin signaling pathway was screened to directly associate with HTN and was regulated by mRNAs PPP1R3C, PPKAR2B and AKT3, miRNA has-miR-107, and lncRNAs SNHG14, TUG1, ZNF252P-AS1 and MIR503HG. CONCLUSIONS: Insulin signaling pathway was directly associated with HTN, and miRNA has-miR-107 and lncRNAs SNHG14, TUG1, ZNF252P-AS1 and MIR503HG were the biomarkers of HTN. +circulation_biomarker_diagnosis_ns 33176710 hsa-mir-10a Inflammation qRT-PCR analysis showed that six miRNAs (miR-10a-5p, - 21-5p, -27b-3p, - 122-5p, -146a-5p, - 423-5p) were significantly increased in plasma EVs from HIV-positive compared to HIV-negative subjects in the validation cohort. +circulation_biomarker_diagnosis_ns 33176710 hsa-mir-10a Acquired Immunodeficiency Syndrome qRT-PCR analysis showed that six miRNAs (miR-10a-5p, - 21-5p, -27b-3p, - 122-5p, -146a-5p, - 423-5p) were significantly increased in plasma EVs from HIV-positive compared to HIV-negative subjects in the validation cohort. +genetics_knock down_promote 33176595 hsa-mir-188 Uterine Cervical Neoplasms CONCLUSION: In this study, we found that DARS-AS1 knockdown suppressed the growth of cervical cancer cells via downregulating HMGB1 via sponging miR +lncRNA target 33176419 hsa-mir-20b Pre-Eclampsia In conclusion, the results indicate that miR-20b may contribute to PE through inhibiting proliferation, invasion and migration of placental trophoblast cells by targeting MCL-1. +genetics_overexpression_suppress 33176298 hsa-mir-340 Brain Injuries Overexpression of miR +genetics_overexpression_suppress 33176298 hsa-mir-340 Cerebral Hemorrhage Overexpression of miR +other 33176280 hsa-mir-30 Urinary Bladder Neoplasms To sum up, circSEMA5A is upregulated in BC and facilitates BC progression by mediating miR5p/ENO1 signaling and upregulating SEMA5A expression. +exosome 33175885 hsa-let-7d Colorectal Neoplasms Exosomes from colorectal cancer cell lines affected CCL7 secretion from CAFs, possibly via the miRNA let-7d, and interfered with the migration of CCR2+ monocytic THP-1 cells in vitro. +other 33175850 hsa-mir-28 Hypertrophy, Right Ventricular qPCR validation of a subset of these miRNAs identified increasing expression of miRNA 28-3p, 433-3p, and 371b-3p to be associated with increasing RV size and decreasing RV systolic function. +other 33175850 hsa-mir-28 Cardiomyopathies qPCR validation of a subset of these miRNAs identified increasing expression of miRNA 28-3p, 433-3p, and 371b-3p to be associated with increasing RV size and decreasing RV systolic function. +other 33175850 hsa-mir-28 Tetralogy of Fallot qPCR validation of a subset of these miRNAs identified increasing expression of miRNA 28-3p, 433-3p, and 371b-3p to be associated with increasing RV size and decreasing RV systolic function. +circulation_biomarker_diagnosis_ns 33175842 hsa-mir-155 Weil Disease Serum miR155-5p and miR630 levels might be novel biomarkers for identifying severe leptospirosis. +circulation_biomarker_diagnosis_ns 33175842 hsa-mir-630 Weil Disease Serum miR155-5p and miR630 levels might be novel biomarkers for identifying severe leptospirosis. +other 33175458 hsa-mir-129 Acute Kidney Injury Besides this, compared with the control group, the expression levels of MEG3 and HMGB1 in samples derived from AKI patients were remarkably upregulated, and the expression of miR5p was downregulated. +other 33175349 hsa-mir-29b Spinal Cord Injuries However, the mechanism by which lncRNA NEAT1 promotes regeneration after spinal cord injury by regulating miR-29b has not been reported. +lncRNA target 33174739 hsa-mir-145 Ovarian Neoplasms This treatment was named a preoperative (T(CD)TMP/miR5p)||intraoperative (surgery and PDT)||postoperative (T(CD)TMP/VEGF-siRNA) therapeutic system and abbreviated as the PIP therapeutic system, which reduced the recurrence of ovarian cancer in subcutaneous tumor models, intraperitoneal metastasis models, and patient-derived tumor xenograft models. +circulation_biomarker_prognosis_ns 33174610 hsa-mir-124 Peripheral Arterial Disease The expression levels of miR1243p in human blood were negatively correlated with anklebrachial index, which is an index for the evaluation of the severity of PAD. +genetics_overexpression_suppress 33174524 hsa-mir-103 Carcinoma, Non-Small-Cell Lung OTUB1 expression and YAP phosphorylation decreased in the presence of miR-103a, and OTUB1 overexpression blocked the inhibitory effects of miR-103a on NSCLC cells. +genetics_overexpression_suppress 33174524 hsa-mir-103a Carcinoma, Non-Small-Cell Lung OTUB1 expression and YAP phosphorylation decreased in the presence of miR-103a, and OTUB1 overexpression blocked the inhibitory effects of miR-103a on NSCLC cells. +genetics_overexpression_promote 33174523 hsa-mir-200c Carcinoma, Non-Small-Cell Lung Under X-ray irradiation, overexpressed PTPRG antisense RNA 1 could promote the viability and enhance the radioresistance of nonsmall cell lung cancer cells, and this effect was partially weakened by miR-200c-3p mimics. +genetics_overexpression_promote 33174326 hsa-mir-29b Diabetic Foot The functional role and interaction of lncRNA H19, miR-29b and FBN1 in DFU were subsequently determined by examining the proliferation, migration, and apoptosis of fibroblasts after silencing H19, inhibiting or overexpressing miR-29b and FBN1. +other 33174291 hsa-mir-21 Leukemia, Lymphocytic, Chronic, B-Cell High-level expression of miR-21 in patients with CLL is associated with a higher risk of death. Our findings describe some of the molecular mechanisms of berberine by decreasing Bcl-2, ROR1, and mir-21 which may be considered as a novel apoptosis inducer in CLL cells. +other 33174081 hsa-mir-155 Multiple Sclerosis This study aims to investigate miR-219 and miR3p expression levels involved in the myelination process following the administration of apamin peptide in the model of multiple sclerosis disease. +other 33174081 hsa-mir-219 Multiple Sclerosis This study aims to investigate miR-219 and miR3p expression levels involved in the myelination process following the administration of apamin peptide in the model of multiple sclerosis disease. +transcription factor target 33174061 hsa-mir-155 Prostatic Neoplasms Rescue experiments were performed to determine the role of the miR155/TERF1 axis in regulating the cellular behaviors of PCa. In conclusion, TERF1, as a direct target of miR155, was discovered to be significantly downregulated in PCa, which was suggested to promote the migration and invasion of PCa via the EMT pathway. +transcription factor target 33174056 hsa-mir-494 Reperfusion Injury Collectively, the results indicated that miR494 served a protective role against H/Rinduced cardiomyocyte apoptosis and autophagy by directly targeting SIRT1, suggesting that miR494 may serve as a novel therapeutic target for myocardial I/R injury. +transcription factor target 33174056 hsa-mir-494 Myocardial Reperfusion Injury Collectively, the results indicated that miR494 served a protective role against H/Rinduced cardiomyocyte apoptosis and autophagy by directly targeting SIRT1, suggesting that miR494 may serve as a novel therapeutic target for myocardial I/R injury. +lncRNA target 33174054 hsa-mir-132 Polycystic Ovary Syndrome Thus, miR132 may be a potential target for the treatment of patients with PCOS. +lncRNA target 33174053 hsa-mir-491 Pre-Eclampsia Collectively, these findings suggested that the aberrant expression of miR4915p may contribute to PE through suppressing trophoblast invasion, thus highlighting the novel roles of miR4915p in the molecular pathogenesis of PE. +lncRNA target 33174051 hsa-mir-195 Myocardial Infarction In conclusion, FGD5AS1 modulated hypoxic injury in human cardiomyocytes partially via the miR195/RORA axis, suggesting FGD5AS1 as a potential target in interfering with the progression of AMI. +lncRNA target 33174051 hsa-mir-195 Hypoxia In conclusion, FGD5AS1 modulated hypoxic injury in human cardiomyocytes partially via the miR195/RORA axis, suggesting FGD5AS1 as a potential target in interfering with the progression of AMI. +lncRNA target 33174047 hsa-mir-619 Osteoporosis In conclusion, the findings of the present study suggested that LINC01535 may accelerate the osteogenic process of hBMSCs via targeting the miR36195p/BMP2 axis, which may offer an innovative therapeutic method for osteoporosis. +genetics_knock down_promote 33174038 hsa-mir-128 Sepsis HULC and RAC1 were found to be upregulated, and miR1283p was downregulated in the serum of patients with sepsis and LPSstimulated HMEC1 cells. In conclusion, HULC knockdown partially reversed LPSinduced sepsis via the regulation of miR1283p/RAC1 axis. +transcription factor target 33174029 hsa-mir-145 Uterine Cervical Neoplasms miR1455p directly targeted FSCN1, which regulated the suppressive functions of miR1455p in CC cells. +lncRNA target 33174014 hsa-mir-516b Carcinoma, Non-Small-Cell Lung Overall, the present findings demonstrated that FEZF1AS1 was upregulated and acted as an oncogene in NSCLC by regulating the ITGA11/miR516b5p axis, suggesting that FEZF1AS1 may be a potential prognostic biomarker and therapeutic target for NSCLC. +circulation_biomarker_diagnosis_up 33174011 hsa-mir-93 Osteoarthritis PVT1, HMGB1 and exosomal PVT1 were upregulated while miR935p was downregulated in osteoarthritis patient serum and LPSinduced C28/I2 cells. In summary, exosomemediated PVT1 regulated LPSinduced osteoarthritis progression by modulating the HMGB1/TLR4/NFkappaB pathway via miR935p, providing a new route for possible osteoarthritis treatment. +other 33174006 hsa-mir-27b Acute Lung Injury The influence of miR27b depletion was reversed by the silencing of TAB2 in an ALI cell model. Collectively, the results suggested that CASC2 attenuated LPSinduced injury in the ALI cell model by modulating the miR27b/TAB2 axis. +lncRNA target 33173989 hsa-mir-106a Glioma In addition, TPTEP1 augmented MAPK14 expression by competitively interacting with microRNA (miR)106a5p, thus activating the P38 MAPK signaling pathway, and suppressing glioma stemness and radioresistance. +genetics_overexpression_promote 33173959 hsa-mir-379 Carcinoma, Non-Small-Cell Lung Tumor and adjacent normal tissues were obtained from patients with NSCLC and transfection experiments in A549 cells were performed using miR3795p mimics and pcDNA3.1 betaarrestin1 (ARRB1) overexpression plasmids. +exosome 33173957 hsa-mir-210 Carcinoma, Renal Cell Moreover, circ_400068 regulated the proliferation of HK2 cells by targeting the miR2105p/SOCS1 axis, as the effects on cell proliferation caused by treatment using exosomes isolated from the culture media of RCC cells were abolished by miR2105p mimics. Collectively, the present findings provided a novel insight into the crucial regulatory functions of circ_400068 in RCC, and the circ_400068/miR2105p/SOCS1 axis could be a candidate therapeutic target for the treatment of patients with RCC. +genetics_overexpression_suppress 33173954 hsa-mir-29c Blind Loop Syndrome The results showed that in zebrafish embryos, miR-29c overexpression attenuated heart development in a dose-dependent manner, manifested by heart rate slowdown, pericardial edema and heart looping disorder. +genetics_overexpression_suppress 33173954 hsa-mir-29c Pericardial Effusion The results showed that in zebrafish embryos, miR-29c overexpression attenuated heart development in a dose-dependent manner, manifested by heart rate slowdown, pericardial edema and heart looping disorder. +other 33173954 hsa-mir-29c Heart Diseases Zebrafish embryos were microinjected with different doses (1, 1.6 and 2 µmol) miR-29c mimics or negative controls, and hatchability, mortality and cardiac malformation were subsequently observed. +lncRNA target 33173953 hsa-mir-3907 Pre-Eclampsia Our research showed that the expression of hsamiR937, hsamiR1486*, hsamiR3907, hsamiR367* and hub genes in the placenta were closely associated with the pathophysiology of EOPE. hsamiR937, hsamiR1486*, hsamiR3907, hsamiR367* and hub genes could serve as biomarkers for diagnosis and as potential targets for the treatment of EOPE. +lncRNA target 33173953 hsa-mir-367 Pre-Eclampsia Our research showed that the expression of hsamiR937, hsamiR1486*, hsamiR3907, hsamiR367* and hub genes in the placenta were closely associated with the pathophysiology of EOPE. hsamiR937, hsamiR1486*, hsamiR3907, hsamiR367* and hub genes could serve as biomarkers for diagnosis and as potential targets for the treatment of EOPE. +lncRNA target 33173953 hsa-mir-1486 Pre-Eclampsia Our research showed that the expression of hsamiR937, hsamiR1486*, hsamiR3907, hsamiR367* and hub genes in the placenta were closely associated with the pathophysiology of EOPE. hsamiR937, hsamiR1486*, hsamiR3907, hsamiR367* and hub genes could serve as biomarkers for diagnosis and as potential targets for the treatment of EOPE. +lncRNA target 33173953 hsa-mir-937 Pre-Eclampsia Our research showed that the expression of hsamiR937, hsamiR1486*, hsamiR3907, hsamiR367* and hub genes in the placenta were closely associated with the pathophysiology of EOPE. hsamiR937, hsamiR1486*, hsamiR3907, hsamiR367* and hub genes could serve as biomarkers for diagnosis and as potential targets for the treatment of EOPE. +genetics_knock down_promote 33173950 hsa-mir-140 Uterine Cervical Neoplasms miR1405p knockdown reversed small interfering RNAFEN1mediated suppressive effects on CC cell phenotypes, potentially via inducing cell cycle arrest at the G1 phase. +exosome 33173749 hsa-mir-22 Breast Neoplasms CD63(+) Cancer-Associated Fibroblasts Confer Tamoxifen Resistance to Breast Cancer Cells through Exosomal miR-22. +lncRNA target 33173535 hsa-mir-184 Carcinoma, Renal Cell Taken together, silencing LINC01094 inhibited SLC2A3 expression by up-regulating miR-184, thereby inhibiting the development of ccRCC. +lncRNA target 33173413 hsa-mir-215 Carcinoma, Hepatocellular In addition, CDC6 promoted proliferation via regulation of G1 phase checkpoint and was negative regulated by miR5p to involve in the proliferation of HCC. +target gene 33173349 hsa-mir-149 Breast Neoplasms Circ_0072995 Promotes Cell Carcinogenesis via Up-Regulating miR-149-5p-Mediated SHMT2 in Breast Cancer. +lncRNA target 33173348 hsa-mir-519e Adenocarcinoma of Lung To be specific, linc01833 can function as a competitive endogenous RNA (ceRNA) to adsorb miR-519e-3p through a sponge and regulate S100A4 in lung cancer, thereby being involved in LUAD progression. +lncRNA target 33173347 hsa-mir-145 Glioma CONCLUSION: Ropivacaine suppressed glioma progression by regulating circSCAF11 and miR +target gene 33173345 hsa-mir-200b Carcinoma, Hepatocellular Xiaoai Jiedu Recipe suppresses hepatocellular carcinogenesis through the miR-200b-3p /Notch1 axis. +genetics_overexpression_promote 33173343 hsa-mir-29a Cholangiocarcinoma Rescue experiment showed that overexpressing miR-29a could reverse the effects of high TUG1 expression on cholangiocarcinoma cells. +circRNA target 33173336 hsa-mir-138 Carcinoma, Hepatocellular 5p blocked HBV replication and expression via targeting TNFAIP3. +genetics_knock down_promote 33173333 hsa-mir-136 Endometrial Neoplasms HMGA2 overexpression abolished the inhibition of miR-136 on EC progression. +genetics_overexpression_promote 33173315 hsa-mir-1297 Osteosarcoma Furthermore, we showed that silencing PFKFB2 inhibited proliferation and reduced aerobic glycolysis while overexpression of PFKFB2 reduced the anti-tumor function of miR-1297 in OS cells. +genetics_GWAS 33173314 hsa-mir-182 Esophageal Neoplasms CONCLUSION: Collectively, our data suggested that LOC441178 overexpression epigenetically inhibited tumorigenesis of ESCC via DNA methylation of miR-182. +lncRNA target 33173017 hsa-mir-155 Carcinoma, Hepatocellular Toll-like receptor 3 (TLR3), a putative miR-155 target, plays a key role in liver pathophysiology, and its downregulation in HCC cells is associated with apoptosis evasion and poor outcomes. +other 33173015 hsa-mir-195 Colorectal Neoplasms At last, by using miRNA-195 mimics, we fortunately found the increased IR-A expression might be due to the degradation of miRNA-195 in CRC. +circulation_biomarker_prognosis_ns 33172871 hsa-mir-146a Leukemia, Myelogenous, Chronic, BCR-ABL Positive This study reported for the first time that measurement of the circulating miR-146a expression at 14 days can predict the early response to imatinib treatment in patients with CML. +lncRNA target 33172486 hsa-mir-224 Stomach Neoplasms CONCLUSIONS: Our findings showed that hsa_circ_0004872 acted as a tumor suppressor in GC by forming a negative regulatory loop consisting of hsa_circ_0004872/miR-224/Smad4/ADAR1. +lncRNA target 33172374 hsa-mir-375 Colorectal Neoplasms miR-27a-3p, PCDH10, GRIN2B, FJX1, Dsc2, and hsa-miR-375 were identified as potential targets for understanding the pathogenic mechanism of CRC. +other 33172167 hsa-mir-196a Mouth Neoplasms 5p and hsa-miR-196a-5p. +other 33172167 hsa-mir-375 Mouth Neoplasms 5p and hsa-miR-196a-5p. +other 33172167 hsa-mir-133a Mouth Neoplasms 5p and hsa-miR-196a-5p. +other 33172167 hsa-mir-503 Mouth Neoplasms 5p and hsa-miR-196a-5p. +lncRNA target 33171523 hsa-mir-195 Esophageal Neoplasms In summary, inhibition of SNHG1 can suppress the cell migration and invasion of EC cells by sponging miR-195 through targeting Cdc42. +lncRNA target 33171493 hsa-mir-29a Leukemia, Lymphocytic, Chronic, B-Cell In CLL, BCR represses miR-29 expression via MYC, allowing for concurrent TRAF4 upregulation and stronger CD40-NF-kappaB signaling. +lncRNA target 33171493 hsa-mir-29 Leukemia, Lymphocytic, Chronic, B-Cell In CLL, BCR represses miR-29 expression via MYC, allowing for concurrent TRAF4 upregulation and stronger CD40-NF-kappaB signaling. +other 33171372 hsa-mir-182 Triple Negative Breast Neoplasms Expression profiling of MSLN, miR-182 and MALAT-1 showed a dramatic over-expression in BC samples. To conclude, our investigation unravels a new axis in TNBC, where miR-182 can manipulate MSLN and PIG-C. +lncRNA target 33170430 hsa-mir-429 Ovarian Neoplasms Silencing of DLEU1 inhibited the proliferation, migration, and invasion of OC cells by regulating miR-429/TFAP2A axis, indicating a potential therapeutic target for OC. +circRNA target 33169939 hsa-mir-24 Carcinoma, Endometrioid 5p remarkably depressed the proliferation, migration and invasion of endometrial cancer cells via inhibiting high mobility group A1 (HMGA1). +other 33169883 hsa-mir-20a Non-Segmental Vitiligo CONCLUSION: Our results showed that divergently expressed miRNAs contribute to the pathogenesis of NSV and that hsa-miR-20a-5p can be applied as a biosignature for stage assessment in PBMCs of patients with NSV. +lncRNA target 33169800 hsa-mir-134 Ovarian Neoplasms 3p may inhibit OC cell proliferation, migration and invasion by directly targeting FEN1. +circulation_biomarker_diagnosis_up 33169519 hsa-mir-1307 Stomach Neoplasms 3p, piR-019308, piR-004918 and piR-018569 in serum exosomes were significantly increased in GC group as compared to those in HC group. +target gene 33168819 hsa-mir-22 Stomach Neoplasms MiR-22, regulated by MeCP2, suppresses gastric cancer cell proliferation by inducing a deficiency in endogenous S-adenosylmethionine. +genetics_GWAS 33168810 hsa-mir-200c Carcinoma, Hepatocellular Our findings demonstrated that alteration of EZH2 gene copy number status induced BMI1-mediated hepatocarcinogenesis via epigenetically silencing miR-200c, providing novel therapeutic targets for HCC treatment. +target gene 33168512 hsa-mir-433 Breast Neoplasms [MiR-433 reverses chemoresistance to docetaxel by targeting Notch1 in breast cancer cells]. +other 33168510 hsa-mir-519d Uterine Cervical Neoplasms OBJECTIVE: To investigate the alterations in gene expression profiles of cervical cancer cell line SiHa over-expressing miR-519d. +other 33168448 hsa-mir-766 Breast Neoplasms CONCLUSION: miR-766 displayed important roles in tumorigenesis and progression in BCa cells and might act as a potential biomarker to predict the chemotherapy response and progression in BCa. +transcription factor target 33168056 hsa-mir-497 Osteoporosis-pseudoglioma syndrome 5p inhibits the development of OP by promoting osteogenesis via targeting HMGA2. +genetics_overexpression_suppress 33168041 hsa-mir-7e Lymphoma RESULTS: We determined that downregulation of miR-7e-5p, driven by c-MYC overexpression, was associated with poorer prognosis in FL patients. +genetics_overexpression_suppress 33168041 hsa-mir-7e Lymphoma, Follicular RESULTS: We determined that downregulation of miR-7e-5p, driven by c-MYC overexpression, was associated with poorer prognosis in FL patients. +transcription factor target 33168024 hsa-mir-340 Lymphoma, Large B-Cell, Diffuse 5p is potentially a novel target for DLBCL immunotherapy. +circulation_biomarker_diagnosis_up 33167959 hsa-mir-205 Uterine Cervical Neoplasms The expression of miR-205 in plasma was also found to be up-regulated in CSCC patients than that in healthy females and inversely correlated with the expression of GATA6-AS in CSCC patients. +other 33167866 hsa-mir-133a Brain Injury, Chronic CONCLUSION: DLEU1 regulated inflammation of the spinal cord and mediated hypersensitivity in neuropathic pain in CCI rats by binding with miR-133a-3p to upregulate SRPK1 expression. +other 33167866 hsa-mir-133a Neuralgia CONCLUSION: DLEU1 regulated inflammation of the spinal cord and mediated hypersensitivity in neuropathic pain in CCI rats by binding with miR-133a-3p to upregulate SRPK1 expression. +lncRNA target 33167678 hsa-mir-128 Lung Neoplasms Mechanistically, we found that PVT1 competes endogenously with miR-128 in the regulation of vascular endothelial growth factor C (VEGFC) expression, which is significantly associated with an unfavorable prognosis in lung cancer. We identified that copy number amplification significantly contributes to the high level of PVT1 transcripts in lung cancer, which promotes cell proliferation and metastatic behavior via modulating VEGFC expression by endogenous competition with miR-128. +lncRNA target 33167431 hsa-mir-214 Melanoma Treating the melanoma cells with rCTII substantially inhibited the transforming growth factor-beta (TGF-beta)-SMAD signaling pathway and down-regulated the expression of MMP-3 and miR-214 as well. +genetics_knock down_promote 33167095 hsa-mir-520a Uterine Cervical Neoplasms After cervical cancer HELA cells stimulated by LPS, in the overexpression group or the knockout group, miR-520a-3p mimics or inhibitor were mixed with transfection reagent and dripped into HELA cells. +lncRNA target 33166679 hsa-mir-520c Plaque, Atherosclerotic In conclusion, our findings suggest that miR-520c-3p inhibits PDGF-BB-mediated the proliferation and migration of HASMCs by targeting RelA/p65, which may provide potential therapeutic strategies in atherosclerosis treatment. +transcription factor target 33166664 hsa-mir-199a Sensation Disorders Overall, miR-199a-5p upregulation is involved in 10 % lidocaine-induced spinal cord toxicity through regulation of MYRF. +other 33166640 hsa-mir-132 Parkinson Disease So, in this study miR-132 and its role in PD cell models was investigated. We observed the expression levels of miR-132 in MPP+ - treated SH-SY5Y cell line, which acted as a PD cell model, and found an increased expression of miR-132. +circRNA target 33166591 hsa-mir-31 Vascular Diseases CONCLUSION: These results revealed that circSFMBT2 plays a vital role in VSMC proliferation and migration through the miR-331/HDAC5/Aggf1 axis, and suggest a novel target for treating proliferative vascular diseases. +transcription factor target 33166496 hsa-mir-10a Intervertebral Disc Degeneration Our study provides a novel mechanism explaining inflammatory cytokine-caused cartilage cell death in degenerative IVD, and makes IL-6/miR-10a-5p/IL-6R axis a potential therapeutic target for intervention of IDD. +transcription factor target 33166496 hsa-mir-10a Substance Abuse, Intravenous Our study provides a novel mechanism explaining inflammatory cytokine-caused cartilage cell death in degenerative IVD, and makes IL-6/miR-10a-5p/IL-6R axis a potential therapeutic target for intervention of IDD. +genetics_overexpression_promote 33166496 hsa-mir-10a Siderosis Overexpressing miR-10a-5p suppressed IL-6R expression, and partially abolished ILinduced ferroptosis. +transcription factor target 33166496 hsa-mir-10a Intervertebral disc disease Our study provides a novel mechanism explaining inflammatory cytokine-caused cartilage cell death in degenerative IVD, and makes IL-6/miR-10a-5p/IL-6R axis a potential therapeutic target for intervention of IDD. +transcription factor target 33166004 hsa-mir-146 Ovarian Failure, Premature CONCLUSIONS: This study demonstrated that HFHS supplementation activates the Dab2ip/Ask1/p38-Mapk signalling pathway and promotes gammaH2A.X phosphorylation by inhibiting the expression of endogenous miR-146b-5p, which results in OGC ageing and POF development. +lncRNA target 33165828 hsa-mir-210 Neurodevelopmental Disorders The highly conserved, hypoxia-regulated microRNA-210 (miR-210) has been shown to be associated with long-term memory in invertebrates and dysregulated in neurodevelopmental and neurodegenerative disease models. +genetics_knock down_promote 33165823 hsa-mir-613 Cicatrix, Hypertrophic 3p or knockdown of ARGLU1 markedly inhibited the expression of extracellular matrix (ECM) production-associated proteins and promoted Caspase-3 and Caspase-9 activations in HSFs. +other 33165673 hsa-mir-19a Myocardial Infarction CCL20 expression was significantly increased in MI tissue samples, but miR-19a was expressed at lower levels in MI. These observations highlighted the therapeutic roles of miR-19a and CCL20 for MI treatment. +circulation_biomarker_diagnosis_down 33165670 hsa-mir-5787 Cerebral Infarction MiR-5787 is demonstrated to be downregulated in peripheral blood mononuclear cells (PBMCs) samples of patients compared with controls, which is negatively associated with inflammatory cytokines of IL-6 and TNF-alpha in ischemic cerebral infarction. +genetics_knock down_promote 33165437 hsa-mir-196 Breast Neoplasms Long non-coding RNA MAFG-AS1 knockdown blocks malignant progression in breast cancer cells by inactivating JAK2/STAT3 signaling pathway via MAFG-AS1/miR-3196/TFAP2A axis. +circRNA target 33165436 hsa-mir-34a Coronary Disease The level of circMGAT1 was downregulated, while miR-34a was strikingly increased in CHD tissues and hypoxia-induced AC16 cells. In conclusion, circMGAT1 inhibited cell apoptosis and enhanced cell proliferation by regulating the miR-34a/YAP1 axis, providing a therapy target for the treatment of human CHD. +lncRNA target 33165429 hsa-mir-10a Carcinoma, Squamous Cell, Cutaneous CONCLUSION: These findings in this study indicate the importance of miR-10a in cSCC cell hallmarks and its use as a novel target for cSCC treatment. +genetics_knock down_suppress 33165137 hsa-mir-490 Myocardial Infarction MIAT knockdown could depress cell proliferation, migration, and invasion through miR +lncRNA target 33165134 hsa-mir-29a Cardiomyopathies TUG1/miR-29a-3p axis might be an underlying therapeutic target for myocardial ischemia. +exosome 33164880 hsa-mir-153 Osteochondritis Dissecans The exosomes of MSCs were isolated and identified, and the MSCs-exosomes with low expression of miR +exosome 33164880 hsa-mir-153 Cardiomyopathies Here, we aim to study the effect and mechanism of miR3p in MSC-derived exosomes on hypoxia-induced myocardial and microvascular damage. +other 33164880 hsa-mir-153 Vascular Calcification 3p) is a vital miRNA which has been proved to modulate cell proliferation, apoptosis, angiogenesis, peritoneal fibrosis and aortic calcification. +other 33164855 hsa-mir-155 Cardiovascular Diseases Moreover, significant associations (p<0.05) were detected between UAs and CVDs biomarkers (ADMA, FABP4, and miR-155). +lncRNA target 33164439 hsa-mir-17 Non-alcoholic Fatty Liver Disease To study the effect of Panax japonicas saponin a(SPJ-a) on nonalcoholic steatohepatitis(NASH) through miR +lncRNA target 33164374 hsa-mir-342 Carcinoma, Hepatocellular Flavonoids of Sophorae Fructus could inhibite the proliferation, migration and invasion of hepatoma cells by regulating LncRNA FBXL19-AS1/miR +lncRNA target 33164271 hsa-mir-4319 Osteosarcoma miR-4319 had an inhibitory influence on OS progression, while WDR1 was a contributor to OS progression. +exosome 33162971 hsa-mir-92 Breast Neoplasms After treatment by CAF-derived exosomes, breast cancer cells express higher programmed cell death receptor ligand 1 (PD-L1), accompanied with increased miR-92 expression. The underlying mechanism of this effect was studied, proliferation and migration of breast cancer cells were increased after the transfection of miR-92, LATS2 was recognized as a target gene of miR-92, and further confirmed by a luciferase assay. +lncRNA target 33162825 hsa-mir-7156 Glioma Cell culture and animal experiments revealed that inhibition of miR +genetics_knock down_promote 33162801 hsa-mir-27b Lymphoma, Large B-Cell, Diffuse HCP5 knockdown reduced MET protein expression, which was subsequently rescued by miR-27b-3p silencing in DLBCL cells. +genetics_knock down_suppress 33162460 hsa-mir-133a intracranial berry aneurysm 3 Moreover, pregnancy-associated plasma protein A (PAPPA) was targeted by miR-133a-3p, and PAPPA overexpression reversed the effects of miR-133a-3p restoration. +circulation_biomarker_diagnosis_up 33162110 hsa-mir-21 Mastitis Although the sensitivity and specificity of miR-21 in the serum to detect bovine mastitis was inferior to miRNA biomarkers in the milk, the significant increase of miR-21 in serum may reflect the impact of local inflammation on the systemic reaction. +genetics_knock down_promote 33162101 hsa-mir-196b Keloid FGF2 overexpression abolished the effect of miR-196b-5p overexpression on keloid fibroblast development. +lncRNA target 33162032 hsa-mir-205 Colorectal Neoplasms Altogether, our results demonstrated that downregulation of LINC01315 suppresses CRC progression by sponging miR +lncRNA target 33161910 hsa-mir-30 Pre-Eclampsia 5p. +lncRNA target 33161770 hsa-mir-146a Cartilage Diseases MicroRNAs (miRNAs) play an important regulatory role in its pathological development, so this study explored the effect and potential mechanism of miR-146a-5p in interleukin (IL)-1beta-induced OA cartilage injury. CONCLUSION: These results suggest that miR-146a-5p inhibits cell proliferation and promotes apoptosis and the inflammatory response in OA cartilage injury by modulating TXNIP. +lncRNA target 33161770 hsa-mir-146a Osteoarthritis CONCLUSION: These results suggest that miR-146a-5p inhibits cell proliferation and promotes apoptosis and the inflammatory response in OA cartilage injury by modulating TXNIP. +circulation_biomarker_diagnosis_ns 33161598 hsa-mir-150 Cholangiocarcinoma Thus, miRNA-150 can be considered as a non-invasive, sensitive serum biomarker for the diagnosis of CCA especially when combined with CA 19-9. +genetics_knock down_promote 33161527 hsa-mir-342 Glioma Moreover, suppression of miR-342 or overexpression of Wnt5a reversed the inhibitory effect of sh-H19 on glioma growth and metastasis. +circulation_biomarker_diagnosis_up 33161496 hsa-mir-27a Parathyroid Neoplasms 5p (p = 0.0694) were upregulated in the serum exosomes of PC patients. +lncRNA target 33161413 hsa-mir-145 Thymic epithelial tumor 5p, a well-known tumor suppressor microRNA downregulated in a variety of tumors, included TETs. +genetics_knock down_promote 33161106 hsa-mir-126 Neuroblastoma In conclusion, our data indicate that OIP5-AS1 promotes the autophagy of PLK2-alpha-synuclein by targeting the miR-126 axis with pathogenic factors, thus reducing the aggregation toxicity of alpha-synuclein, which It will help better to understand the mechanism of dopaminergic neuron loss in PD and provide novel treatment options. +other 33161100 hsa-mir-122 Osteoarthritis RESULTS: Both miR-122 and miR-451 were increased in the OA articular cartilage compared to healthy tissue; rArCs expressed both microRNAs in MVs. +other 33161100 hsa-mir-122 Anterior Cruciate Ligament Injuries METHODS: miR-122 and miR-451 presence in rat articular cartilage was assessed using the anterior cruciate ligament transection model of OA. +other 33161100 hsa-mir-451 Osteoarthritis RESULTS: Both miR-122 and miR-451 were increased in the OA articular cartilage compared to healthy tissue; rArCs expressed both microRNAs in MVs. +other 33161100 hsa-mir-451 Anterior Cruciate Ligament Injuries METHODS: miR-122 and miR-451 presence in rat articular cartilage was assessed using the anterior cruciate ligament transection model of OA. +lncRNA target 33160992 hsa-mir-497 Diabetic Nephropathies SIGNIFICANCE: ANRIL promotes pyroptosis and kidney injury in DN via acting as miR-497 sponge to disinhibit TXNIP expression. +other 33160737 hsa-mir-146a Leukemia The present study attempts to investigate the roles of miR-146a-5p in regulating cytokine expression in a human monocytic leukemia cell line (THP-1). +lncRNA target 33160003 hsa-mir-107 Nasopharyngeal Carcinoma Further analysis showed that circTGFBR2 sponged miR-107, leading to the upregulation of TGFBR2 expression and suppression of NPC progression. +exosome 33159957 hsa-mir-296 Breast Neoplasms miR-9, miR5p, miR-19a, miR-126, miR-130a, miR-132, miR-296, and miR-378) in exosomes derived from DHA-treated BC cells, TDE (DHA+). +exosome 33159957 hsa-mir-132 Breast Neoplasms miR-9, miR5p, miR-19a, miR-126, miR-130a, miR-132, miR-296, and miR-378) in exosomes derived from DHA-treated BC cells, TDE (DHA+). +exosome 33159957 hsa-mir-378 Breast Neoplasms miR-9, miR5p, miR-19a, miR-126, miR-130a, miR-132, miR-296, and miR-378) in exosomes derived from DHA-treated BC cells, TDE (DHA+). +exosome 33159957 hsa-mir-130a Breast Neoplasms miR-9, miR5p, miR-19a, miR-126, miR-130a, miR-132, miR-296, and miR-378) in exosomes derived from DHA-treated BC cells, TDE (DHA+). +exosome 33159957 hsa-mir-19a Breast Neoplasms miR-9, miR5p, miR-19a, miR-126, miR-130a, miR-132, miR-296, and miR-378) in exosomes derived from DHA-treated BC cells, TDE (DHA+). +exosome 33159957 hsa-mir-9 Breast Neoplasms miR-9, miR5p, miR-19a, miR-126, miR-130a, miR-132, miR-296, and miR-378) in exosomes derived from DHA-treated BC cells, TDE (DHA+). +exosome 33159957 hsa-mir-17 Breast Neoplasms miR-9, miR5p, miR-19a, miR-126, miR-130a, miR-132, miR-296, and miR-378) in exosomes derived from DHA-treated BC cells, TDE (DHA+). +lncRNA target 33159675 hsa-mir-155 Alcoholism 5p downregulation attenuates myocardial insulin resistance, which might become a potential therapeutic target for alcohol-induced cardiomyopathy. +lncRNA target 33159675 hsa-mir-155 Cardiomyopathies 5p downregulation attenuates myocardial insulin resistance, which might become a potential therapeutic target for alcohol-induced cardiomyopathy. +genetics_knock down_promote 33159506 hsa-mir-378a Ovarian Neoplasms Ovarian cancer OVCAR3 and SKOV3 cells were transfected or cotransfected with miR-378a-3p mimic or pcDNA3.1-PDIA4 or their negative control plasmids to explore their roles in biological functions in ovarian cancer cells. +genetics_knock down_suppress 33159503 hsa-mir-873 Carcinoma, Non-Small-Cell Lung 5p knockdown attenuated the influence of circ_0031250 silence on NSCLC progression in the presence of genistein. +transcription factor target 33159388 hsa-mir-22 Fatty Liver Our data reveal the pathways and mechanisms through which miR-22 regulates lipid metabolism and suggest that miR-22 inhibitors may have potential as candidate drugs for NAFLD and obesity. +genetics_overexpression_suppress 33159291 hsa-mir-361 Ovarian Neoplasms All the results above explained that BBOX1-AS1 was overexpressed in OC and that BBOX1-AS1 caused carcinogenic influences on OC cell growth via miR +genetics_knock down_suppress 33159035 hsa-mir-185 Liver Injury More importantly, we found that the protective effects of circ-CBFB knockdown on p66Shc, mitochondrial dynamics and liver injury were abolished by miR +lncRNA target 33159017 hsa-mir-587 Intervertebral Disc Degeneration Inhibiting miR-587 counteracted the IDD-enhancing effect caused by silencing CircGLCE. Thus, CircGLCE attenuates IDD by inhibiting the apoptosis of NP cells and ECM degradation through the targeting of miR-587/STAP1. +circulation_biomarker_diagnosis_ns 33159015 hsa-mir-9 Adenocarcinoma of Lung 5p to modulate the level of Cytoplasmic Polyadenylation Element Binding Protein 3 (CPEB3) in LUAD. +other 33158935 hsa-mir-125a Pleuropulmonary blastoma miR-125a-3p, a candidate to regulate YY1 expression and lung branching, was abnormally highly expressed in PPB samples. +circulation_biomarker_diagnosis_ns 33158661 hsa-mir-371 Neoplasms, Germ Cell and Embryonal Our study demonstrated that the plasma miR371-miR375 integrated evaluation is highly accurate to detect teratoma. +circulation_biomarker_diagnosis_ns 33158661 hsa-mir-371 Teratoma Our study demonstrated that the plasma miR371-miR375 integrated evaluation is highly accurate to detect teratoma. +circulation_biomarker_diagnosis_ns 33158661 hsa-mir-371a Teratoma Our study demonstrated that the plasma miR371-miR375 integrated evaluation is highly accurate to detect teratoma. +circulation_biomarker_diagnosis_ns 33158661 hsa-mir-371a Neoplasms, Germ Cell and Embryonal Our study demonstrated that the plasma miR371-miR375 integrated evaluation is highly accurate to detect teratoma. +other 33157942 hsa-mir-210 Pre-Eclampsia 3p-ADAMTS6 axis might be a potential regulatory mechanism in PE. +lncRNA target 33157501 hsa-mir-195 Uterine Cervical Neoplasms 3p might inhibit cervical cancer cell proliferation and was reversely regulated by BCDIN3D. +circulation_biomarker_diagnosis_ns 33157494 hsa-mir-200b Chronic Periodontitis CONCLUSIONS: miR-223 and miR-200b have a potential role in chronic periodontitis pathogenesis associated with type 2 diabetes, with the ability to induce tumor necrosis factor-alpha secretion, while miR-203 might have a protective and healing role due to the negative correlation with the serum tumor necrosis factor-alpha levels found. +circulation_biomarker_diagnosis_ns 33157494 hsa-mir-203 Chronic Periodontitis CONCLUSIONS: miR-223 and miR-200b have a potential role in chronic periodontitis pathogenesis associated with type 2 diabetes, with the ability to induce tumor necrosis factor-alpha secretion, while miR-203 might have a protective and healing role due to the negative correlation with the serum tumor necrosis factor-alpha levels found. +circulation_biomarker_diagnosis_ns 33157494 hsa-mir-223 Diabetes Mellitus, Type 2 CONCLUSIONS: miR-223 and miR-200b have a potential role in chronic periodontitis pathogenesis associated with type 2 diabetes, with the ability to induce tumor necrosis factor-alpha secretion, while miR-203 might have a protective and healing role due to the negative correlation with the serum tumor necrosis factor-alpha levels found. +circulation_biomarker_diagnosis_ns 33157494 hsa-mir-223 Chronic Periodontitis CONCLUSIONS: miR-223 and miR-200b have a potential role in chronic periodontitis pathogenesis associated with type 2 diabetes, with the ability to induce tumor necrosis factor-alpha secretion, while miR-203 might have a protective and healing role due to the negative correlation with the serum tumor necrosis factor-alpha levels found. +circulation_biomarker_diagnosis_ns 33157494 hsa-mir-203 Diabetes Mellitus, Type 2 CONCLUSIONS: miR-223 and miR-200b have a potential role in chronic periodontitis pathogenesis associated with type 2 diabetes, with the ability to induce tumor necrosis factor-alpha secretion, while miR-203 might have a protective and healing role due to the negative correlation with the serum tumor necrosis factor-alpha levels found. +circulation_biomarker_diagnosis_ns 33157494 hsa-mir-200b Diabetes Mellitus, Type 2 CONCLUSIONS: miR-223 and miR-200b have a potential role in chronic periodontitis pathogenesis associated with type 2 diabetes, with the ability to induce tumor necrosis factor-alpha secretion, while miR-203 might have a protective and healing role due to the negative correlation with the serum tumor necrosis factor-alpha levels found. +other 33157164 hsa-mir-10a Osteoporosis CONCLUSION: Our data expounded that Kaempferol boosted BMSC osteogenic differentiation and ameliorated osteoporosis by lessening miR-10a-3p and raising CXCL12. +genetics_knock down_promote 33156701 hsa-mir-150 Ovarian Neoplasms Conclusion: This study reveals that knockdown of PRLB improves the sensitivity of ovarian cancer cells to Tax, at least in part, through inhibiting the activation of RSF1/NF-kappaB signaling through targeting miR5p. +circulation_biomarker_diagnosis_up 33155933 hsa-mir-223 Prostatic Diseases Also, observation of similar serum levels of miR +other 33155836 hsa-mir-125b Carcinoma, Hepatocellular Conclusion: miR-224 had a prominent diagnostic efficiency in early-stage HCC, with miR-224 and miR-125b being valuable in the prognostic diagnosis. +other 33155514 hsa-mir-182 Diabetes Mellitus, Type 2 3p have been down-regulated in different biological sources of patients with T2DM. +other 33155514 hsa-mir-126 Diabetes Mellitus, Type 2 3p have been down-regulated in different biological sources of patients with T2DM. +other 33155514 hsa-mir-1 Diabetes Mellitus, Type 2 3p have been down-regulated in different biological sources of patients with T2DM. +other 33155514 hsa-let-7b Diabetes Mellitus, Type 2 3p have been down-regulated in different biological sources of patients with T2DM. +lncRNA target 33155431 hsa-mir-34a Migraine Disorders Recent studies have shown that up-regulation of miR-34a-5p expression is associated with acute migraine attacks. In summary, these findings suggest that miR-34a-5p up-regulates the IL-1beta/COX2/PGE2 inflammation pathway, induces apoptosis and enhances release of CGRP via inhibition of SIRT1 expression in trigeminal ganglion neurons; thus, miR-34a-5p may have potential as a therapeutic target for the treatment of migraine. +other 33155364 hsa-mir-23a Carcinoma, Hepatocellular Taken together, our results demonstrated that the miR-23a-STAT5A-AKT signaling pathway is critical to alter glucose metabolism in HCC and may offer new opportunities for effective therapy. +genetics_overexpression_promote 33155266 hsa-mir-361 Retinoblastoma 3p mimic-mediated suppressive effect on aggressive phenotypes was abolished after overexpression of STX17 in RB cells. +target gene 33155265 hsa-mir-9 Urinary Bladder Neoplasms Target inhibition on GSK-3β by miR-9 to modulate proliferation and apoptosis of bladder cancer cells. +genetics_overexpression_suppress 33155244 hsa-mir-34a Inflammation MiR-34a-5p directly inhibited the expression of FOXM1, and its overexpression alleviated the protective effect of FOXM1 on cell viability, apoptosis, inflammation factor production, and vasculogenic activity. +transcription factor target 33155227 hsa-mir-340 Acute Liver Injury Then miR-340 mimic and inhibitor were used to up-regulate or down-regulate the function of miR-340 to explore anti-inflammation function to ALI via the target of Sigirr. +genetics_overexpression_promote 33155220 hsa-mir-28 Pulmonary Embolism 3p, and the overexpression of API5 in miR +lncRNA target 33155218 hsa-mir-223 Thrombosis OBJECTIVE: The aim of this study was to observe the regulatory effects of micro ribonucleic acid (miR)-223 on thromboangiitis obliterans (TAO) rats, and to explore the potential regulatory mechanism. CONCLUSIONS: MiR-223 agonist can alleviate thrombus and inflammatory response in TAO rats. +lncRNA target 33155218 hsa-mir-223 Thromboangiitis Obliterans OBJECTIVE: The aim of this study was to observe the regulatory effects of micro ribonucleic acid (miR)-223 on thromboangiitis obliterans (TAO) rats, and to explore the potential regulatory mechanism. CONCLUSIONS: MiR-223 agonist can alleviate thrombus and inflammatory response in TAO rats. +lncRNA target 33155218 hsa-mir-223 Inflammation OBJECTIVE: The aim of this study was to observe the regulatory effects of micro ribonucleic acid (miR)-223 on thromboangiitis obliterans (TAO) rats, and to explore the potential regulatory mechanism. CONCLUSIONS: MiR-223 agonist can alleviate thrombus and inflammatory response in TAO rats. +other 33155212 hsa-mir-1324 Lung Neoplasms In addition, circ-PRKCI can compete with MECP2 to bind microRNA-1324 and thus affect the progression of LCa. +genetics_overexpression_promote 33155211 hsa-mir-1 Nasopharyngeal Carcinoma Overexpression of LOC554202 downregulated microRNA-31 expression but upregulated that of RhoA, which may be a potential mechanism for the implication of LOC554202 in NPC. +genetics_overexpression_promote 33155209 hsa-mir-548b Colorectal Neoplasms Overexpression of miR-548b suppressed proliferative capacity and induced apoptosis in CRC cells. +genetics_overexpression_promote 33155208 hsa-mir-143 Colorectal Neoplasms Overexpression of KDM2A facilitated the tumorigenesis of CRC, while this effect was reversed by the upregulation of miR-143. CONCLUSIONS: Our study demonstrated that LINC01278 upregulated KDM2A to promote CRC progression by interacting with miR-143, suggesting that LINC01278 might be a new therapeutic target of CRC. +genetics_overexpression_promote 33155203 hsa-mir-136 Pancreatic Carcinoma Moreover, recovery experiments demonstrated that ZNF32 overexpression reversed the inhibitory effect on the malignant progression of gemcitabine-resistant PCa cells induced by microRNA +genetics_knock down_promote 33155202 hsa-mir-148b Pancreatic Carcinoma The inhibitory effect of CASC19 knockdown on the progression of PC was reversed by the down-regulation of miR-148b or up-regulation of E2F7. The CASC19/miR-148b/E2F7 axis might be a new study direction for PC treatment. +lncRNA target 33155201 hsa-mir-4465 Carcinoma, Hepatocellular CONCLUSIONS: LINC00240 sponges miR-4465 to promote HCC cells proliferation, migration and invasion via HGF/c-MET signaling pathway. +other 33155199 hsa-mir-144 Carcinoma, Renal Cell 3p to upregulate MYCN. +other 33155198 hsa-mir-16 Uterine Cervical Neoplasms OBJECTIVE: The aim of this study was to explore the effects of micro ribonucleic acid (miR)-16 on the proliferation and apoptosis of cervical cancer (CC) cells and its related regulatory mechanism. +other 33155197 hsa-mir-655 Endometrial Neoplasms 3P expression. +lncRNA target 33155195 hsa-mir-513a Ovarian Neoplasms CONCLUSIONS: MiR-513a-3p plays a critical role in promoting sensitivity to cisplatin and tumorigenesis via targeting HOXB7 in ovarian cancer. +genetics_overexpression_promote 33155194 hsa-mir-127 Ovarian Neoplasms After lentivirus-mediated overexpression of miR +lncRNA target 33155190 hsa-mir-655 Pre-Eclampsia 3p is involved in the development of PE by regulating biological features of trophoblasts by targeting PBX3. +other 33155176 hsa-mir-3123 Stroke MMP9, ITGAM, CCR1, NCF2, CD163, hsa-miR-3123 and hsa-miR3p are potential diagnostic and prognostic biomarkers of UAP-related stroke. +other 33155176 hsa-mir-144 Stroke MMP9, ITGAM, CCR1, NCF2, CD163, hsa-miR-3123 and hsa-miR3p are potential diagnostic and prognostic biomarkers of UAP-related stroke. +lncRNA target 33155080 hsa-mir-142 Stomach Neoplasms CONCLUSIONS: Our findings suggest that circTMEM87A functions as an oncogene through the miR +virus_miRNA 33154957 hbv-mir-3 HBV-related Hepatocellular Carcinoma HBV-miR-3 binds to the 3'-UTR of PTEN mRNA and downregulates PTEN protein expression, thereby reducing cell apoptosis and enhancing cell invasion and proliferation. +other 33154782 hsa-mir-132 Colorectal Neoplasms Therefore, miR3p may serve as a molecular marker, which may be used to predict CRC resistance to 5-FU, and HF may serve as a novel clinical treatment for 5-FU-resistant CRC. +lncRNA target 33154768 hsa-mir-605 Osteosarcoma MicroRNA (miR)-605 has been demonstrated to act as a prognostic biomarker and therapeutic target in various cancers, such as breast cancer and non-small cell lung cancer, but its function in OS remains unclear. +lncRNA target 33154765 hsa-mir-31 Stomach Neoplasms These data suggest that MIAT promotes GC progression via modulating miR +transcription factor target 33154755 hsa-mir-574 Arthritis, Rheumatoid This is a novel mechanism by which sEV and miRs contribute to RA pathogenesis and indicate that pharmacological inhibition of extracellular miR5p might offer new therapeutic strategies to protect osteoclast-mediated bone destruction in RA. +lncRNA target 33154676 hsa-mir-490 Adenocarcinoma of Lung 3p inhibited the proliferation, migration, invasion and promoted the apoptosis of LUAD cells by down-regulating the Wnt/beta-catenin signaling pathway, suggesting that miR +genetics_overexpression_promote 33154669 hsa-mir-193a Carcinoma, Hepatocellular METHODS: A real-time polymerase chain reaction (RT-PCR) assay was carried out to quantify lncRNA UCA1 and microRNA-193a-3p in HCC tissues and cells, and relevant overexpression or inhibition vectors were constructed to analyze the influences of lncRNA UCA1 and microRNA-193a-3p on HCC cells. +genetics_knock down_promote 33154668 hsa-mir-206 Leukemia, Myeloid, Acute MiR-206 overexpression suppressed the malignant behaviors of AML cells, while PRKACB elevation restored the effects. +lncRNA target 33154575 hsa-mir-1 Breast Neoplasms 3p in breast cancer cells inhibited cell viability, invasion, migration, and epithelial-to-mesenchymal transition, and suppressed tumor formation and metastasis. +circulation_biomarker_diagnosis_ns 33154212 hsa-mir-21 Carcinoma, Non-Small-Cell Lung A fourfold change in serum miRNA 21 is significantly associated with the diagnosis of NSCLC with a high specificity of 97% and area under curve of 0.84 (95% confidence interval of 0.74-0.94). CONCLUSION: Estimation of serum miRNA 21 expression has potential to be used as liquid biopsy for the diagnosis of NSCLC. +other 33154193 hsa-mir-638 Glioblastoma Dual-luciferase reporter assay determined that circ_0043278 directly sponged miR-638 to upregulate the expression of HOXA9, which can activate downstream Wnt/beta-catenin signaling in GBM. These results showed that circ-0043278/miRNA-638/ Homeobox A9 (HOXA9) axis had a vital function in promoting GBM progression. +lncRNA target 33154189 hsa-mir-132 Stomach Neoplasms Moreover, silencing of lncRNA XIST and up-regulation of miR-132 could suppress tumor formation ability, cell proliferation and migration, but enhanced apoptosis in gastric cancer. +genetics_overexpression_promote 33153768 hsa-mir-1246 Glioma Overexpression of miR-1246 promoted cell proliferation, migration and invasion in glioma cells. +lncRNA target 33153492 hsa-mir-145 Ovarian Diseases CONCLUSIONS: Our study verified that multiple intravenous injections of hPD-MSCs led to improved ovarian function via miR5p and BMP-SMAD signaling and proposed the future therapeutic potential of hPD-MSCs to promote ovarian function in women at advanced age to improve their quality of life during climacterium. +lncRNA target 33153492 hsa-mir-145 Breast Diseases CONCLUSIONS: Our study verified that multiple intravenous injections of hPD-MSCs led to improved ovarian function via miR5p and BMP-SMAD signaling and proposed the future therapeutic potential of hPD-MSCs to promote ovarian function in women at advanced age to improve their quality of life during climacterium. +circRNA target 33153478 hsa-mir-142 Stomach Neoplasms CONCLUSION: circCUL2 may function as a tumor suppressor and regulator of cisplatin sensitivity through miR +lncRNA target 33153429 hsa-let-7a Thyroid Cancer, Papillary RESULTS: The stability of commonly used ECs RNU48 and let-7a significantly differs from the stability of target miRNA in archival FFPE PTC tissues. +circulation_biomarker_diagnosis_ns 33153128 hsa-mir-15b Erdheim-Chester Disease Six miRNAs (let-7a, let-7c, miR-15a-5p, miR-15b-5p, miR-107 and miR-630) were highly expressed in LCH plasma and tissue samples as compared with ECD. +lncRNA target 33153128 hsa-let-7 Erdheim-Chester Disease Moreover, the let-7 family members were downregulated in untreated ECD patients as compared with HC, while treatment with MAPK/ERK signaling inhibitors for 16 weeks resulted in their upregulation, which was in parallel with the radiologic response seen by PET-CT. +circulation_biomarker_diagnosis_ns 33153128 hsa-mir-107 Erdheim-Chester Disease Six miRNAs (let-7a, let-7c, miR-15a-5p, miR-15b-5p, miR-107 and miR-630) were highly expressed in LCH plasma and tissue samples as compared with ECD. +circulation_biomarker_diagnosis_ns 33153128 hsa-let-7c Erdheim-Chester Disease Six miRNAs (let-7a, let-7c, miR-15a-5p, miR-15b-5p, miR-107 and miR-630) were highly expressed in LCH plasma and tissue samples as compared with ECD. +circulation_biomarker_diagnosis_ns 33153128 hsa-let-7a Erdheim-Chester Disease Six miRNAs (let-7a, let-7c, miR-15a-5p, miR-15b-5p, miR-107 and miR-630) were highly expressed in LCH plasma and tissue samples as compared with ECD. +lncRNA target 33152231 hsa-mir-185 Trichohepatoenteric Syndrome Our previous high-throughput sequencing found that ssc-miR-185 plays an important regulatory role in piglet diarrhea, but its specific target genes and functions in intestinal porcine epithelial cell (IPEC-J2) are still unclear. However, the detailed regulatory mechanism of miR-185/CDC42 axis in piglets' resistance to diarrhea is yet to be elucidated in further investigation. +lncRNA target 33151961 hsa-mir-21 Necrosis Furthermore, kaempferol eliminated H/R-induced oxidative stress and inflammatory response as illustrated by the decreases in reactive oxygen species generation and malondialdehyde content, the increases in antioxidant enzyme superoxide dismutase and glutathione peroxidase activities, the decreases in pro-inflammatory cytokines interleukin (IL)-1beta, IL-8 and tumor necrosis factor-alpha levels, and an increase in anti-inflammatory cytokine IL-10 level, while these effects of kaempferol were all reversed by miR-21 inhibitor. +genetics_overexpression_promote 33151903 hsa-mir-126 Parathyroid Neoplasms 3p is expressed by both endothelial cells and TAMs in PAds, and its downregulation promotes neoangiogenesis, possibly through VEGFA overexpression. +lncRNA target 33151563 hsa-mir-155 Necrosis The morphology, inflammatory factor (tumor necrosis factor-alpha [TNF-alpha]), necroptosis-related genes (RIP1, RIP3, MLKL, and caspase 8), MAPK pathway-related genes (JNK, ERK, and p38, p-JNK, p-ERK, and p-p38), gga-miR-155, TRAF3 (predicted target of gga-miR-155), and oxidative stress-related indicators (SOD, MDA, CAT, GSH, and GSH-Px) were analyzed from the perspective of the miR-155/TRAF3/MAPK axis to elucidate the mechanism of methionine selenium on the LPS-induced necroptosis mechanism in the chicken liver. At the same time, methionine selenium affects miR-155/TRAF3/MAPK signaling, reduces miR-155 expression, and upregulates TRAF3 expression to inhibit necroptosis. +other 33151462 hsa-mir-34c Atherosclerosis However considering the possible effects of other underlying diseases on both BANCR expression and miR-34c in atherosclerosis, further investigation is suggested for future research. +genetics_overexpression_promote 33151036 hsa-mir-483 Carcinoma, Renal Cell Overexpression of miR +lncRNA target 33151000 hsa-mir-455 Squamous Cell Carcinoma of Head and Neck 5p targeted PTPRS directly to affect its downstream indicators, which can further modulate OSCC cell proliferation and growth. +other 33150936 hsa-mir-200a Diabetic Retinopathy In conclusion, our findings demonstrated that miR-200a-3p-elevated prevented DR progression by blocking the TGF-beta2/Smad pathway, providing a new therapeutic biomarker for DR treatment in the clinic. +lncRNA target 33150879 hsa-mir-34a Colorectal Neoplasms phosphoethanolamine-N- (polyethyleneglycol) (DSPE-PEG), in which IRI and a tumor suppressive microRNA-34a (miR-34a) gene were efficiently co-loaded (MINPs) to achieve a chemo-miRNA combination therapy against CRC. +other 33150795 hsa-mir-370 Glioma 3p-Wnt7a axis. +lncRNA target 33150676 hsa-mir-646 Laryngeal Neoplasms The present study aimed to explore the potential roles and mechanisms of miR-646 in laryngeal carcinoma cells. Taken together, miR-646 prohibited the proliferation and invasion of laryngeal carcinoma cells through the PI3K/AKT pathway via targeting GPX1. +lncRNA target 33150481 hsa-mir-367 Cerebral Hemorrhage MiR-367 regulates microglia polarization by targeting CEBPA and is expected to alleviate ICH-induced inflammatory injury. +circulation_biomarker_diagnosis_ns 33150164 hsa-mir-136 Diabetes, Gestational CONCLUSION: Collectively, miR-136 expression is increased in both serum and placental tissues in GDM patients, and miR-136 mediates the inhibiting effect of high glucose on trophoblast cell viability by targeting E2F1. +transcription factor target 33150086 hsa-mir-139 Carcinoma, Hepatocellular Hsa-miR5p low or targeted DEmRNA high expression was associated with low macrophage infiltration, high grade, advanced stage and poor prognosis of HCC. +target gene 33150075 hsa-mir-29a Uterine Cervical Neoplasms miR-29a-3p directly targets Smad nuclear interacting protein 1 and inhibits the migration and proliferation of cervical cancer HeLa cells. +other 33149731 hsa-mir-19b Radiation-Induced Pulmonary Fibrosis We found that thoracic tumor patients whose lung regions received radiation showed lower level of microRNA-19b-3p (miR-19b-3p). +circulation_biomarker_diagnosis_ns 33149711 hsa-mir-181a Pelvic Organ Prolapse The objective of this study was to assess serum elastin, type I collagen, miRNA-30d, and miRNA-181a in the early postpartum period to identify hematologic predictors of POP. Conclusion miRNA-30d and miRNA-181a tended to be increased in women with POP and could be potential clinical predictors. +genetics_overexpression_promote 33149682 hsa-mir-205 Stomach Neoplasms The dual-luciferase reporter assay revealed that YAP1 could be targeted and regulated by miR-205, and the rescue assay revealed that inhibiting miR-205 or overexpressing YAP1 could weaken the effect of propofol on the biological behaviors of SC cells. +exosome 33149680 hsa-mir-613 Carcinoma, Non-Small-Cell Lung CONCLUSION: MALAT1 promoted malignant activities of NSCLC cells through targeting miR-613/COMMD8 axis, and exosome-mediated transfer of NSCLC might be a novel approach for NSCLC treatment. +target gene 33149676 hsa-mir-513a Breast Neoplasms LncRNA ADAMTS9-AS1 Restrains the Aggressive Traits of Breast Carcinoma Cells via Sponging miR-513a-5p. +genetics_knock down_promote 33149675 hsa-mir-195 Adenocarcinoma of Lung CONCLUSION: circ_0020850 knockdown repressed lung adenocarcinoma cell proliferation, migration and invasion and promoted apoptosis via regulating miR +lncRNA target 33149666 hsa-mir-15b Squamous Cell Carcinoma of Head and Neck Further silencing of PTPN4 blocked the inhibiting functions of miR-15b-5p inhibitor in OSCC cell growth. +transcription factor target 33149621 hsa-mir-1247 Squamous Cell Carcinoma of Head and Neck DISCUSSION: Thus, we conclude that OODBL inhibits OSCC progression by modulating miR3p/LXRalpha/ABCA1 signaling. +target gene 33149617 hsa-mir-590 Carcinoma, Pancreatic Ductal Hsa-MiR-590-3p Promotes the Malignancy Progression of Pancreatic Ductal Carcinoma by Inhibiting the Expression of p27 and PPP2R2A via G1/S Cell Cycle Pathway. +target gene 33149615 hsa-mir-149 Urinary Bladder Neoplasms Hsa_circRNA_100146 Acts as a Sponge of miR-149-5p in Promoting Bladder Cancer Progression via Regulating RNF2. +target gene 33149611 hsa-mir-339 Ovarian Neoplasms Long-Chain Non-Coding RNA SNHG3 Promotes the Growth of Ovarian Cancer Cells by Targeting miR-339-5p/TRPC3 Axis. +circRNA target 33149610 hsa-mir-613 Pancreatic Carcinoma MiR-613 suppressed the progression of PC. +other 33149605 hsa-mir-497 Stomach Neoplasms LINC01572 Regulates Cisplatin Resistance in Gastric Cancer Cells by Mediating miR-497-5p. +lncRNA target 33149570 hsa-mir-1246 Pulmonary Disease, Chronic Obstructive GO and KEGG enrichment analysis revealed miR-1246 to be associated with target genes in several pathways involved in COPD/emphysema development. +lncRNA target 33149126 hsa-mir-181a Melanoma The in vitro and in vivo results showed that LHFPL3-AS1-long directly interacted with miR-181a-5p to inhibit the mRNA degradation of Bcl-2 (the target of miR-181), thus suppressing apoptosis of melanoma stem cells. +genetics_knock down_suppress 33148890 hsa-mir-198 Osteoporosis Taken together, hsa_circ_0002060 knockdown alleviated the progression of OP by targeting miR5p. +circulation_biomarker_diagnosis_ns 33148842 hsa-mir-155 psoriasis 1 RESULTS: Results: It has been studied an effect of antiviral therapy on the background of basic therapy in patients with P+HSV 1,2: the percentage of HSV 1,2 DNA detection after the use of acyclovir and/or inosine pranobex was decreased in saliva from 22.0+/-3.43 % to 6.7+/-1.32 % (small er, Cyrillic<0.01) and in epithelium - from 33.3+/-4.23 % to 6.7+/-1.8 % (small er, Cyrillic<0.01); The use of antiviral therapy has showed a decrease in the expression of miR 155 molecules from 126.3 /-10.5 U/6 to 62.4+/-5.48 U/6 (small er, Cyrillic<0.05), an increase in the number of T-regulatory lymphocytes from 6.8+/-1.25% to 9.1+/-1.41% (p=0.0503); a decrease of IFN-alpha level in saliva from10.1+/-1.84 ng/ml to 8.2+/-1.27 ng/ml (small er, Cyrillic1=0.0398); in the serum IL-23 level was significantly decreased from14.9+/-2.11 pg/ml to 8.8+/-2.03 pg/ml (small er, Cyrillic<0.05) and TGF-beta synthesis was increased from 3.9+/-1.23 pg/ml to 9.3+/-2.21 pg/ml (small er, Cyrillic<0.01). +genetics_knock down_suppress 33148417 hsa-mir-133b Ischemic Stroke SIGNIFICANCE: Taken together, circ-HECTD1 knockdown inhibited the expression of TRAF3 by targeting miR-133b, thereby attenuating neuronal injury caused by cerebral ischemia. +genetics_knock down_suppress 33148417 hsa-mir-133 Ischemic Stroke SIGNIFICANCE: Taken together, circ-HECTD1 knockdown inhibited the expression of TRAF3 by targeting miR-133b, thereby attenuating neuronal injury caused by cerebral ischemia. +lncRNA target 33148375 hsa-mir-183 Obesity Overall, this study highlights the role of miR5p in myogenic differentiation through FHL1 repression and suggests a novel miRNA-mediated mechanism for myogenesis in a background of obesity. +other 33148251 hsa-mir-539 Adenocarcinoma of Lung 5p-CENPF axis may be involved in regulating hypoxia induced tumor cell stemness in LUAD. +genetics_overexpression_promote 33148101 hsa-mir-362 Paranasal Sinus Neoplasms PTTG1 overexpression mitigated miR +genetics_overexpression_promote 33148101 hsa-mir-362 Pituitary Neoplasms PTTG1 overexpression mitigated miR +genetics_knock down_suppress 33148068 hsa-mir-155 Diabetes, Gestational 5p microRNAs differentially expressed in circulating leukocytes of pregnant women with polycystic ovary syndrome and gestational diabetes. +genetics_knock down_suppress 33148068 hsa-mir-155 Polycystic Ovary Syndrome 5p microRNAs differentially expressed in circulating leukocytes of pregnant women with polycystic ovary syndrome and gestational diabetes. +circulation_biomarker_diagnosis_up 33147705 hsa-mir-122 Non-alcoholic Fatty Liver Disease Our results showed that omega-3 PUFA were incorporated in erythrocytes after six months of fish oil supplementary intake, and that n-3 PUFA were effective in reducing ALP and liver fibrosis without altering the expression of circulating miR-122 in individuals with NAFLD. +transcription factor target 33147588 hsa-mir-146a Osteoarthritis CONCLUSION OX40L and miR-146a-5p of condylar chondrocytes in the inflammatory environment (induced by IL-1 and TNF-) were significantly increased, miR-146a-5p is a protective factor in the inflammatory response, which can reduce the production of inflammatory factors, and miR-146a-5p may regulate T-cell-mediated immunity through targeting of ox40l in OA. +transcription factor target 33147588 hsa-mir-146 Osteoarthritis CONCLUSION OX40L and miR-146a-5p of condylar chondrocytes in the inflammatory environment (induced by IL-1 and TNF-) were significantly increased, miR-146a-5p is a protective factor in the inflammatory response, which can reduce the production of inflammatory factors, and miR-146a-5p may regulate T-cell-mediated immunity through targeting of ox40l in OA. +lncRNA target 33147570 hsa-mir-21 Adenocarcinoma of Lung CONCLUSIONS: LINC00968 limits LUAD progression via the miR5p/SMAD7 axis and may serve as a prognostic biomarker and therapeutic target for LUAD. +lncRNA target 33147380 hsa-mir-214 Brain Injuries Herein, we explore the role of microRNA-214 (miR-214) in the occurrence of brain injury after general anaesthesia and its underlying mechanism. Taken together, the study demonstrates inhibition of miR-214 is cerebral protective against brain injury following general anaesthesia. +genetics_overexpression_promote 33147167 hsa-mir-27a Brain Injuries, Traumatic DEX promoted the effects of circLrp1b in attenuating TBI-induced neurologic impairment, autophagy, and inflammation, which was significantly reversed by inhibition of miR-27a-3p or Dram2 overexpression. +lncRNA target 33147068 hsa-mir-624 Esophageal Squamous Cell Carcinoma 3p enhanced cancer cell viability, proliferation, migration, and invasion but inhibited apoptosis in ESCC. +lncRNA target 33147064 hsa-mir-193b Colorectal Neoplasms 3p that target MRPL43 may serve as potential predictive biomarkers of CRC survival. +lncRNA target 33147064 hsa-mir-194 Colorectal Neoplasms 3p that target MRPL43 may serve as potential predictive biomarkers of CRC survival. +genetics_knock down_promote 33147052 hsa-mir-650 Stomach Neoplasms Simultaneous knockdown of miR-650 and LATS2 reduced GC cell apoptosis. +genetics_knock down_promote 33147052 hsa-mir-650 Helicobacter pylori Simultaneous knockdown of miR-650 and LATS2 reduced GC cell apoptosis. +exosome 33147048 hsa-mir-128 Colorectal Neoplasms To conclude, the circ-FBXW7 delivery by exosomes could ameliorate chemoresistance to oxaliplatin in CRC by directly binding to miR3p, suggesting a promising therapeutic strategy for oxaliplatin-resistant CRC patients. +genetics_knock down_promote 33146951 hsa-mir-185 Carcinoma, Non-Small-Cell Lung Besides, knockdown of MALAT1 inhibited tumor growth in vivo through miR +genetics_overexpression_promote 33146718 hsa-mir-1298 Breast Neoplasms ADAM9 was overexpressed in BC tissues and inversely correlated with miR-1298. +circulation_biomarker_diagnosis_up 33146702 hsa-mir-19b Esophageal Neoplasms The expression of miR-19b-3p in ESCA plasma, cells and exosomes was significantly up-regulated. +lncRNA target 33146672 hsa-mir-195 Paranasal Sinus Neoplasms Down-regulating NEAT1 inhibited the viability and vasculogenic mimicry formation of SNSCC cells yet promoted their apoptosis via the miR +other 33146403 hsa-mir-215 Inflammation The present study aimed to investigate the effects of miR-215 on lipopolysaccharide (LPS)-induced inflammatory injury in CCD-18Co cells, as well as to identify the underlying possible molecular mechanisms. +other 33146403 hsa-mir-215 Inflammatory Bowel Disease 11 It has been reported that the expression of microRNA (miR)-215 is upregulated in patients with long-term UC. +lncRNA target 33146288 hsa-mir-660 Breast Neoplasms 5p/TET2 axis might be a promising target for BC treatment. +target gene 33146005 hsa-mir-491 Uterine Cervical Neoplasms KCNQ1 opposite strand/antisense transcript 1 promotes aggressive biological behaviors of cervical cancer cells via regulating microRNA-491-5p and pyruvate kinase M1/2. +genetics_knock down_promote 33146000 hsa-mir-338 Osteosarcoma Knockdown of miR +genetics_knock down_promote 33145937 hsa-mir-223 Syphilis Moreover, NLRP3 overexpression or knockdown largely blocked the effects of miR +genetics_GWAS 33145433 hsa-mir-499 Biliary Atresia AIM OF THE STUDY: We aimed to evaluate the association of microRNA-499 rs3746444 polymorphism and biliary atresia (BA) risk and its correlation with clinic-pathologic features of BA. +lncRNA target 33145301 hsa-mir-139 Osteosarcoma A competing endogenous RNA (ceRNA) network of miR5p and six candidate lncRNAs was also suggested as targeting HMGB2 in osteosarcoma. +other 33145269 hsa-mir-150 Stomach Neoplasms Furthermore, we identified numerous miRNAs and lncRNAs with a significant expression correlation with GC immunity, including hsa-miR-150, 155, 142, 342, 146, 101, 511, 29, AC022706.1, LINC01871, and AC006033.2. +genetics_knock down_suppress 33145050 hsa-mir-2054 Cardiomegaly CONCLUSIONS: Knockdown of KCNQ1OT1 could attenuate cardiac hypertrophy through modulation of the miR-2054/AKT3 axis. +exosome 33144675 hsa-mir-423 Prostatic Neoplasms PC-associated fibroblast-derived exosomes carrying miR +other 33144628 hsa-mir-185 Carcinoma, Hepatocellular Thought a WGCNA we identified miR-3185 and miR-4507 as promising candidate biomarkers predicting a longer survival in HCC patients. +other 33144628 hsa-mir-4507 Carcinoma, Hepatocellular Thought a WGCNA we identified miR-3185 and miR-4507 as promising candidate biomarkers predicting a longer survival in HCC patients. +genetics_GWAS 33144602 hsa-mir-21 Mastocytoma, Skin In conclusion, the present study demonstrated that the miRNA expression profile is changed in the MCT microenvironment, suggesting the involvement of the altered miRNAs in the epigenetic regulation of MCTs and identifying miR-21, miR-379 and miR-885 as promising biomarkers. +genetics_GWAS 33144602 hsa-mir-885 Mastocytoma, Skin In conclusion, the present study demonstrated that the miRNA expression profile is changed in the MCT microenvironment, suggesting the involvement of the altered miRNAs in the epigenetic regulation of MCTs and identifying miR-21, miR-379 and miR-885 as promising biomarkers. +genetics_GWAS 33144602 hsa-mir-379 Mastocytoma, Skin In conclusion, the present study demonstrated that the miRNA expression profile is changed in the MCT microenvironment, suggesting the involvement of the altered miRNAs in the epigenetic regulation of MCTs and identifying miR-21, miR-379 and miR-885 as promising biomarkers. +transcription factor target 33144585 hsa-mir-671 Prostatic Neoplasms 5p promoted PCa development and metastasis by suppressing NFIA/ CRYAB axis. +circulation_biomarker_diagnosis_up 33144571 hsa-mir-18a Osteoarthritis And the level of serum miR-18a was positively correlated to severity of OA. +lncRNA target 33144185 hsa-mir-937 Breast Neoplasms 5p inhibition significantly repressed the proliferation of breast carcinoma cells and elicited S-phase cell cycle arrest. +genetics_overexpression_promote 33144090 hsa-mir-218 Parkinson Disease 5p and overexpressed LASP1 existed in the brain SN of PD rats. +other 33143053 hsa-mir-98 COVID-19 Since we and others have shown that endothelial cells play a pivotal role in the pathogenesis of the coronavirus disease 2019 (COVID-19), we mechanistically validated miR5p as a regulator of TMPRSS2 transcription in two different human endothelial cell types, derived from the lung and from the umbilical vein. +lncRNA target 33142454 hsa-mir-6615 Immune System Diseases In summary, our results suggest that NH(3) exposure negatively affected meat yield; and miR-6615/Smad7 axis and immune imbalance participated in NH(3)-induced inflammatory injury via the NF-kappaB pathway in broiler kidneys. +lncRNA target 33142454 hsa-mir-6615 Inflammation In summary, our results suggest that NH(3) exposure negatively affected meat yield; and miR-6615/Smad7 axis and immune imbalance participated in NH(3)-induced inflammatory injury via the NF-kappaB pathway in broiler kidneys. +genetics_overexpression_promote 33142243 hsa-mir-524 Melanoma Overexpression of miR +exosome 33142041 hsa-mir-24 Diabetes Mellitus Hence, the findings of this study reveal the regulatory role of Dia-Exos in the process of wound healing and provide experimental evidence for the therapeutic effects of knocking down miR3p in DFU treatment. +other 33140399 hsa-mir-338 Diabetes Mellitus, Type 1 CONCLUSIONS: KLRD1, hisa-miR-181a, and hisa-miR-181c might be pathogenic biomarkers for T1DM, ACTA2, USP9Y, and hsa-miR3p progressive biomarkers of T1DM. +other 33140399 hsa-mir-181c Diabetes Mellitus, Type 1 CONCLUSIONS: KLRD1, hisa-miR-181a, and hisa-miR-181c might be pathogenic biomarkers for T1DM, ACTA2, USP9Y, and hsa-miR3p progressive biomarkers of T1DM. +other 33140399 hsa-mir-181a Diabetes Mellitus, Type 1 CONCLUSIONS: KLRD1, hisa-miR-181a, and hisa-miR-181c might be pathogenic biomarkers for T1DM, ACTA2, USP9Y, and hsa-miR3p progressive biomarkers of T1DM. +lncRNA target 33140323 hsa-mir-149 Stomach Neoplasms CONCLUSIONS: Our results indicated an important role of circRNA_0044516 in GC and elucidated that downregulation of circRNA_0044516 inhibits the proliferation of GC cells through miR-149/Wnt1/beta-catenin. +genetics_knock down_promote 33140250 hsa-mir-23b Carcinoma, Hepatocellular Proliferation of HCC cells was activated by miR-23b-3p overexpression and diminished by its knockdown. +genetics_knock down_suppress 33139818 hsa-mir-21 Uterine Cervical Neoplasms 5p and tissue inhibitor of metalloproteinases-3 (TIMP3) in cervical cancer were accessed via gain- and loss-of-function approaches. +other 33139749 hsa-mir-71a Urinary Bladder Neoplasms Our results revealed that IHA is a reliable test in the diagnosis of bilharziasis associated with bladder cancer, and that Sha-miR-71a and MAPK-3 provide non-invasive specific biomarkers to diagnose BBC, as well as a potential role in testing bilharzial patients for risk to develop cancer. +lncRNA target 33139574 hsa-mir-409 Charcot-Marie-Tooth disease type 1B 3p, promotes CSMN subtype identity in part via repression of LMO4, a key transcriptional regulator of CPN development. +genetics_knock down_promote 33139493 hsa-mir-183 Pre-Eclampsia Gain- and loss-of-function experiments were conducted to explore modulatory effects of miR-183, FOXP1, and GNG7 on the viability, invasion, and angiogenesis of trophoblast cells in PE. +other 33138861 hsa-mir-126 Graft vs Host Disease CONCLUSION These results suggest hucMSC-based miRNA3p gene therapy may be a novel option for the treatment of vein graft disease after CABG. +transcription factor target 33138697 hsa-mir-9 Uveal melanoma 5p mimics and inhibitor. +genetics_knock down_promote 33138677 hsa-mir-195 Prostatic Neoplasms FKBP1A overexpression could rescue the effects of miR +genetics_knock down_promote 33138667 hsa-mir-101 Uterine Cervical Neoplasms 5p, and its downregulation reversed the inhibitory effects of hsa_circ_0007364 knockdown on CC progression. +transcription factor target 33137828 hsa-mir-381 Obesity Furthermore, our findings suggested that miR-381 and its target gene(s) might represent new targets for investigating intramuscular fat deposits in cattle and treating human obesity. +other 33137205 hsa-mir-30 Myocardial Reperfusion Injury CONCLUSIONS: Our study indicated that the miR5p/TIM3 axis was involved in the regulatory mechanism of NLRP3 inflammasome-mediated myocardial inflammation. +genetics_knock down_promote 33137086 hsa-mir-190b Lung Neoplasms Collectively, our study developed an in vivo miRNA knockout platform for functionally screening in GEMM and identified miR-190b as a new tumor suppressor in lung cancer. +genetics_knock down_promote 33137086 hsa-mir-146a Lung Neoplasms Using this in vivo knockout screening, we identified miR-30b and miR-146a, which has been previously reported as tumor suppressors and miR-190b, a new tumor-suppressive miRNA in lung cancer development. +circRNA target 33136699 hsa-mir-873 Breast Neoplasms Mechanistically, circTP63 binds to miR3p and prevents the targeting of FOXM1, thus inducing the progression and malignant behaviors of estrogen receptor-positive breast cancer, such as cell proliferation, cell cycle dysregulation, invasion, migration and even tumor growth. +genetics_overexpression_suppress 33136092 hsa-mir-20a Carcinoma, Hepatocellular BMSCs-EVs with overexpressing miR-20a-3p further enhanced the apoptotic effect of HCC cells in vitro and in vivo. +lncRNA target 33135476 hsa-mir-141 Rift Valley Fever In conclusion, TUG1 promotes EMT in TGF-beta1-induced HK-2 cells via upregulation of beta-catenin levels by sponging miR3p, suggesting a novel therapeutic candidate for RIF. +other 33135394 hsa-mir-503 Pulmonary Fibrosis In conclusion, miR-503 exerted protective roles in silica-induced pulmonary fibrosis and may represent a novel and potent candidate for therapeutic strategies in silicosis. +genetics_overexpression_promote 33135351 hsa-mir-654 Arthritis, Rheumatoid CONCLUSIONS: LncRNA ENST00000494760 overexpression may sponge miR +transcription factor target 33135345 hsa-mir-15b COVID-19 3p, and miR-15b-5p as potential contributors to the disease pathogenesis, possibly serving as biomarkers of severe COVID-19 and as candidate therapeutic targets. +genetics_knock down_promote 33135290 hsa-mir-584 Carcinoma, Hepatocellular 5p or overexpression of CDK16 could suppress the HCC cell proliferation. +genetics_overexpression_promote 33135285 hsa-mir-18 Ovarian Neoplasms Functional experiments showed that SNHG15 overexpression potentiated the migration and invasion of OC cells, while SNHG15 inhibition reduced the tumor proliferation, which was restored via overexpression of miR-18a. +genetics_overexpression_promote 33135285 hsa-mir-18a Ovarian Neoplasms Functional experiments showed that SNHG15 overexpression potentiated the migration and invasion of OC cells, while SNHG15 inhibition reduced the tumor proliferation, which was restored via overexpression of miR-18a. +circRNA target 33135071 hsa-mir-337 Osteoarthritis Overall, our data expounded that the interference with circRNA_0092516 boosted chondrocyte proliferation and restrained cell apoptosis through the miR +other 33135066 hsa-mir-130a Renal Insufficiency, Chronic Large EVs from CAD CKD patients contained significantly lower levels of the vasculo-protective miR-130a-3p and miR3p compared to CAD patients and controls. +other 33135066 hsa-mir-126 Renal Insufficiency, Chronic Large EVs from CAD CKD patients contained significantly lower levels of the vasculo-protective miR-130a-3p and miR3p compared to CAD patients and controls. +circulation_biomarker_diagnosis_up 33134795 hsa-mir-125b Endometriosis miR-125b is upregulated in both endometriotic tissues and serum samples of women with endometriosis but its potential targets in endometriosis are still not fully understood. +lncRNA target 33134385 hsa-mir-155 Thyroid Cancer, Papillary As a conclusion, CASC2 increases 131I sensitivity in PTC by sponging miR-155, providing a novel target for the treatment of thyroid cancer patients with 131I resistance. +genetics_overexpression_promote 33134300 hsa-mir-135a Fetal Alcohol Spectrum Disorders These results demonstrated that ethanol-induced downregulation of miR-135a contributes to ethanol-induced apoptosis in NCCs by upregulating Siah1 and activating the p38 MAPK/p53 pathway and that the overexpression of miRNA-135a can protect against ethanol-induced apoptosis in NCCs and craniofacial defects in a zebrafish model of FASD. +other 33133386 hsa-mir-106 Carcinoma, Hepatocellular 3p/miR-941) showed a 94.1% sensitivity and 68.4% specificity to differentiate HCC patients from non-HCC patients. +other 33133386 hsa-mir-941 Carcinoma, Hepatocellular 3p/miR-941) showed a 94.1% sensitivity and 68.4% specificity to differentiate HCC patients from non-HCC patients. +other 33133386 hsa-mir-628 Carcinoma, Hepatocellular 3p/miR-941) showed a 94.1% sensitivity and 68.4% specificity to differentiate HCC patients from non-HCC patients. +other 33133386 hsa-mir-584 Carcinoma, Hepatocellular 3p/miR-941) showed a 94.1% sensitivity and 68.4% specificity to differentiate HCC patients from non-HCC patients. +circulation_biomarker_diagnosis_ns 33133386 hsa-mir-223 Carcinoma, Hepatocellular RESULTS: The principal component analysis suggested that daily alcohol consumption could alter the blood exosomal miRNA profiles of hepatitis B virus positive non-HCC patients through miR-3168 and miR3p. +genetics_overexpression_promote 33133267 hsa-mir-1236 Osteosarcoma 3p overexpression inhibited OS cell migration and proliferation compared with the negative control group. +genetics_overexpression_promote 33133259 hsa-mir-454 Esophageal Squamous Cell Carcinoma 3p overexpression significantly suppressed cell proliferation, migration and invasion and promoted apoptosis in four ESCA cell lines (EC9706, ECA109, TE-1 and TE-8). +lncRNA target 33133224 hsa-mir-873 Thyroid Cancer, Papillary In conclusion, the results of this study indicated that circFAT1(e2) played a carcinogenic role by targeting the miR-873/ZEB1 axis to promote PTC invasion and metastasis, which might become a potential novel target for therapy of PTC. +other 33132904 hsa-mir-363 Ischemic Stroke Histological analysis showed significant deterioration of specific white matter tracts due to stroke, which was attenuated in mir363-3p treated animals. +transcription factor target 33132818 hsa-mir-1 Peripheral Nerve Injuries To summarize, EA may promote the proliferation, migration of SC, and nerve repair after PNI by regulating miR-1b, which targets BDNF. +transcription factor target 33132251 hsa-mir-133a Bronchial Hyperreactivity In human BSM cells (hBSMCs), an up-regulation of RhoA was observed when the function of endogenous miR-133a was inhibited by its antagomir. +transcription factor target 33132251 hsa-mir-133a Asthma, Allergic In human BSM cells (hBSMCs), an up-regulation of RhoA was observed when the function of endogenous miR-133a was inhibited by its antagomir. +other 33132210 hsa-mir-193a Wolfram Syndrome 3p) decreased and was directly correlated with neuroimaging indicators of neurodegeneration. +other 33132210 hsa-mir-22 Wolfram Syndrome 3p) decreased and was directly correlated with neuroimaging indicators of neurodegeneration. +other 33132210 hsa-mir-145 Wolfram Syndrome 3p) decreased and was directly correlated with neuroimaging indicators of neurodegeneration. +other 33132210 hsa-mir-375 Wolfram Syndrome 3p) decreased and was directly correlated with neuroimaging indicators of neurodegeneration. +other 33132210 hsa-let-7g Wolfram Syndrome 3p) decreased and was directly correlated with neuroimaging indicators of neurodegeneration. +genetics_overexpression_promote 33131925 hsa-mir-221 Osteosarcoma RESULTS: The results showed that the overexpression of miR-221 in OS cells dramatically promoted cell growth and cell cycle progression, and inhibited apoptosis, whereas miR-221 inhibitors conversely inhibited proliferation and promoted apoptosis in OS cells. +lncRNA target 33131511 hsa-mir-210 Myocarditis [Silencing miRNA210 Alleviates Myocardial Cell Damage in Myocarditis by Hypoxia Inducible Factor-vascular Endothelial Growth Factor Pathway]. Objective To investigate the effect of miRNA210 on primary myocardial cells in lipopolysaccharide(LPS)-induced myocarditis.Methods CCK8 method was used to detect the effect of miRNA210 on the viability of primary myocardial cells in normal or LPS-induced myocarditis rats.ELISA was performed to detect the secretion of tumor necrosis factor(TNF)- and interleukin(IL)-1 after miRNA210 treatment.Flow cytometry was used to detect the apoptosis of primary myocardial cells before and after the intervention.Western blotting was used to detect the expression of TNF- and IL-1.The expression of apoptosis-related proteins bcl-2,bax,caspase-3,and hypoxia inducible factor 1 (HIF1)-vascular endothelial growth factor(VEGF)were detected by Western blotting.Results CCK8 detection results showed that,compared with the control group,the effect of miRNA210 mimic(t=0.000,P=1.000)and siRNA(t=0.686,P=0.500)interference had no significant difference on primary rat cardiomyocytes.The viability of rat primary cardiomyocytes significantly decreased after LPS treatment(t=8.764,P<0.001);compared with LPS group,the viability of rat primary cardiomyocytes significantly increased after inhibition of miRNA210(t=3.576, P=0.012).ELISA showed that,compared with the control group,the expressions of IL-1 (t=4.166,P=0.014)and TNF-(t=6.309,P=0.003)were significantly up-regulated after LPS induction;compared with the LPS group,the expressions of IL-1 (t=4.096,P=0.015)and TNF-(t=4.424,P=0.011)were significantly increased after application of miRNA210 mimic.After silencing miRNA210,IL-1 (t=4.287,P=0.012)and TNF-(t=3.577,P=0.023)were significantly down-regulated.Flow cytometry showed that,compared with the control group,the apoptosis of primary cardiomyocytes induced by LPS was significantly increased(t=32.780,P<0.001);compared with LPS group,the apoptosis induced by LPS was significantly aggravated by miRNA210 mimic(t=7.412,P= 0.002),and the apoptosis rate of primary cardiomyocytes was significantly decreased after miRNA210 was silenced(t=11.720,P<0.001).Western blot analysis showed that,compared with the control group,LPS significantly down-regulated the expression of bcl-2(t=8.346,P=0.001)and increased the expressions of bax(t=12.890,P<0.001)and caspase-3(t=4.331,P=0.012).Compared with LPS group,the expression of bcl-2(t=6.074,P<0.001)was significantly decreased,and the expressions of bax(t=5.376,P=0.022)and caspase-3(t=5.859,P=0.004)were increased after miRNA210 mimic.After silencing miRNA210,the expression of bcl-2 significantly increased(t=3.873,P=0.017),the expressions of bax(t=5.205,P=0.006)and caspase-3(t=2.800,P=0.040)significantly decreased.Compared with the control group,the expressions of HIF1(t =10.380,P=0.001)and VEGF(t=4.973,P=0.008)were significantly up-regulated in LPS group.Compared with LPS group,the expressions of HIF1(t=8.952,P<0.001)and VEGF(t=11.203,P=0.001)were significantly up-regulated after miRNA210 mimic was applied,while HIF1(t=3.893,P=0.017)and VEGF expression(t=3.181,P=0.033)were decreased after miRNA210 was silenced.Compared with LPS group,the expressions of bax(t= 4.899,P=0.008),HIF1(t=2.833,P=0.047),caspase-3(t=2 VEGF(t= 2.994, P=0.040)were significantly decreased,and the expression of bcl-2 was increased(t=3.392,P=0.017).Conclusion Silencing miRNA210 can attenuate LPS-induced cardiomyocyte injury through HIF1-VEGF-mediated apoptotic pathway. +circulation_biomarker_diagnosis_up 33131509 hsa-mir-132 Depression Objective To investigate the expression levels of miRNA132 in patients with the first-episode major depressive disorder(MDD) and in chronic unpredictable mild stress(CUMS)rats.Methods Forty-one first-episode MDD patients(MDD group)were recruited from the outpatient departments of Hangzhou Seventh People's Hospital between March 2017 and May 2018,and 31 healthy volunteers(control group)were recruited.The patients' severity of symptoms was assessed with HAMD17.In addition,24 male SD rats were equally assigned into control group and CUMS group.The depression-like behaviors of rats was detected by sucrose preference test and forced swimming test.Plasma corticosterone levels of rats were assayed by ELISA.The expression levels of miRNA132 in the blood or prefrontal cortex were detected by quantitative real-time PCR.Results The expression level of miRNA132 in peripheral blood was significantly higher in MDD group(2.37+/-0.36)than in control group(1.34+/-0.16)(t=2.355,P=0.0213),and there was a positive correlation between miRNA132 levels and the HAMD17 score in MDD group(P=0.0004,r(s)=0.5303,n=41).The immobility time of CUMS group [(72.67+/-2.95)s] was significantly longer than that of control group [(40.00+/-5.49)s] in forced swim test(t=2.366,P=0.0395).The sucrose intake of CUMS group [(55.67+/-6.42)%] was significantly lower than that of control group [(98.21+/-1.28)%] in sucrose preference test(t=6.502,P<0.0001).The plasma corticosterone level in CUMS group [(1396.0+/-254.9)nmol/L] was significantly higher than that of control group [(557.3+/-158.4)nmol/L](t=2.795,P=0.0190).The miRNA132 levels in blood(2.32+/-0.88)and prefrontal cortex(2.80+/-0.76)of CUMS rats were significantly higher than those [1.18+/-0.36(t=2.273,P=0.0463)and 0.99+/-0.23(t=2.553,P=0.0287),respectively] of control group.Conclusions The expression trend of miRNA132 in peripheral blood is consistent between MDD patients and CUMS rats.In CUMS rats,the expression of miRNA132 in blood is also consistent with that in prefrontal cortex.The expression of miRNA132 in blood may reflect the change trend of miRNA132 expression in prefrontal cortex. +genetics_knock down_promote 33131409 hsa-mir-129 Multiple Myeloma Circ_0007841 knockdown inhibited MM cell proliferation, metastasis and chemoresistance through modulating miR +lncRNA target 33131397 hsa-mir-199b Multiple Myeloma CONCLUSION: Our data displayed that miR-199b-5p was sequestered by LRRC75A-AS1 so that PDCD4 was released to repress MM, implying the targeting miR-199b-5p as a novel thought for improving MM therapy. +lncRNA target 33131267 hsa-mir-126 Stomach Neoplasms miR-126 targeting GOLPH3 inhibits the epithelial-mesenchymal transition of gastric cancer BGC-823 cells and reduces cell invasion. +lncRNA target 33131207 hsa-mir-192 Colorectal Neoplasms 3p-FRAS1 axis may be an anti-metastatic target for CRC patients. +lncRNA target 33131207 hsa-mir-761 Colorectal Neoplasms 3p-FRAS1 axis may be an anti-metastatic target for CRC patients. +other 33130681 hsa-mir-25 Reperfusion Injury, Cerebral Ischemia This work aimed to unearth the role and potential mechanism of miR3p in regulating neuronal survival in CIR injury. +transcription factor target 33130456 hsa-mir-143 Venous Thrombosis MiR3p targets ATG2B to modulate the function of EPCs and recanalization and resolution of DVT. +exosome 33130420 hsa-mir-619 Squamous Cell Carcinoma of Head and Neck CONCLUSION: Exosomal HEIH acted as a ceRNA for miR3619-5p to upregulate HDGF, thereby promoting DDP resistance in TSCC cells. +genetics_knock down_suppress 33130075 hsa-mir-130b Oophoritis Consistently, downregulation of miR-130b in ovariectomy (OVX) rats dropped off the beneficial effect of ortho-silicic acid against bone loss. +transcription factor target 33130075 hsa-mir-130b Osteoporosis SIGNIFICANCE: In conclusion, our findings reveal that ortho-silicic acid promotes the osteogenesis of osteoblasts mediated by the miR-130b/PTEN signaling axis, which identifies a new target to prevent and treat osteoporosis. +genetics_knock down_suppress 33130075 hsa-mir-130b Bone Diseases Consistently, downregulation of miR-130b in ovariectomy (OVX) rats dropped off the beneficial effect of ortho-silicic acid against bone loss. +other 33129786 hsa-mir-373 Sepsis 3p/TRIM8 axis. +other 33129786 hsa-mir-373 Acute Liver Injury 3p/TRIM8 axis. +circulation_biomarker_diagnosis_ns 33129342 hsa-mir-150 Carcinoma, Non-Small-Cell Lung MiRNA-150, a gene regulator that has been revealed to be abnormal expression in non-small cell lung cancer (NSCLC), can be regarded as a serum indicator for diagnosis and monitoring of NSCLC. More importantly, the proposed method can distinguish the expression of serum miRNA-150 among NSCLC patients and healthy people. +circulation_biomarker_prognosis_ns 33129241 hsa-mir-661 Alzheimer Disease RESULTS: The in silico analysis demonstrated the highlighted roles of metabolic and cellular response to stress pathways engaged in circulating hsa-miR +circRNA target 33129036 hsa-mir-454 Pre-Eclampsia DISCUSSION: Circ-AK2 inhibited the proliferation, migration and invasion of trophoblast cells via targeting miR +lncRNA target 33128918 hsa-mir-27b Temporomandibular Joint Dysfunction Syndrome CONCLUSION: The results suggest that XIST modulates SMSCs chondrogenic differentiation via the miR-27b-3p/ADAMTS-5 axis, which provides new targets for TMJOA treatment. +other 33128684 hsa-mir-182 Urinary Bladder Neoplasms Herein, the expression patterns of miR-182, miR-205, miR-27a and miR-369 were evaluated in patients with urothelial BCa. +other 33128684 hsa-mir-369 Urinary Bladder Neoplasms Herein, the expression patterns of miR-182, miR-205, miR-27a and miR-369 were evaluated in patients with urothelial BCa. +other 33128684 hsa-mir-205 Urinary Bladder Neoplasms Herein, the expression patterns of miR-182, miR-205, miR-27a and miR-369 were evaluated in patients with urothelial BCa. +other 33128684 hsa-mir-27a Urinary Bladder Neoplasms Herein, the expression patterns of miR-182, miR-205, miR-27a and miR-369 were evaluated in patients with urothelial BCa. +genetics_knock down_suppress 33128668 hsa-mir-135a Inflammation Rescue assays indicated that knockdown of miR-135a partially rescued small interference RNA for GAS5-inhibited inflammatory cytokines release and oxidative stress in ox-LDL-triggered THP-1 cells. +genetics_knock down_suppress 33128584 hsa-mir-1271 Carcinoma, Endometrioid CONCLUSION Circ_0000043 knockdown inhibited the progression of EC by regulating miR +other 33128541 hsa-mir-10a Obesity Taken together, these results revealed a potential role of miR-10a-5p in adipogenesis and in the treatment of obesity. +other 33128354 hsa-mir-543 Pancreatic Carcinoma The expression of miR-543 could also predict the survival of patients with PC, which suggested that miR-543 might play an important role in PC. +lncRNA target 33128289 hsa-mir-942 Colorectal Neoplasms 5p could directly target DLG2 mRNA, thus enhancing the malignancy phenotypes of CRC cells. +other 33128199 hsa-mir-26a Breast Neoplasms The real time PCR assay was carried out with miR-26a-5p for evaluate to expression level of MDA-MB-231 breast cancer cell and MCF-12A non-cancerous epithelial breast cell. Moreover, miR-26a-5p might be used as a biomarker in the treatment of breast cancer but further analysis is required. +circulation_biomarker_diagnosis_up 33128129 hsa-mir-375 Coronary Disease Our results might suggest maternal serum miR +other 33128129 hsa-mir-375 Heart Diseases 3p) was involved in cardiac dysfunction and cardiogenesis. +genetics_overexpression_promote 33127881 hsa-mir-140 Tuberculosis 3p silencing resulted in an increase in BTB permeability by targeting ZAK, while overexpression of miR +circulation_biomarker_diagnosis_up 33127881 hsa-mir-140 high grade glioma 3p was downregulated in glioma-exposed endothelial cells (GECs) of BTB compared with those in endothelial cells cocultured with astrocytes (ECs) of blood-brain barrier (BBB). +transcription factor target 33127874 hsa-mir-192 Stomach Neoplasms Taken together, we investigated the functional significance, molecular mechanisms, and clinical impact of miR-192/215/SET8/p53 in GC. +transcription factor target 33127874 hsa-mir-215 Stomach Neoplasms Taken together, we investigated the functional significance, molecular mechanisms, and clinical impact of miR-192/215/SET8/p53 in GC. +other 33127387 hsa-mir-132 Fibrosis 3p as crucial regulators of fibrotic pathways in an in vitro model of human cardiac fibroblast biology. +other 33127387 hsa-mir-20a Fibrosis 3p as crucial regulators of fibrotic pathways in an in vitro model of human cardiac fibroblast biology. +lncRNA target 33127171 hsa-mir-125b Cystic Fibrosis 3p we observed a fold change (FC) expression <2 of the majority of miRNAs (403/479, 84.13%), whereas we identified a list of dysregulated miRNAs, suggesting that specific miRNA inhibition (in our case miR +lncRNA target 33127171 hsa-mir-155 Cystic Fibrosis 3p we observed a fold change (FC) expression <2 of the majority of miRNAs (403/479, 84.13%), whereas we identified a list of dysregulated miRNAs, suggesting that specific miRNA inhibition (in our case miR +lncRNA target 33126850 hsa-mir-145 Stomach Neoplasms CONCLUSION: Bupivacaine exerted an anti-tumor role to suppress the progression of gastric cancer through reducing the abundance of circ_0000376 and up-regulating miR +other 33126452 hsa-mir-7 Coronary Artery Disease 5p and hsa-miR-99a-5p) consistently upregulated by greater than twofold in groups with CAD. +other 33126452 hsa-mir-210 Coronary Artery Disease 5p and hsa-miR-99a-5p) consistently upregulated by greater than twofold in groups with CAD. +other 33126452 hsa-mir-29b Coronary Artery Disease 5p and hsa-miR-99a-5p) consistently upregulated by greater than twofold in groups with CAD. +other 33126452 hsa-mir-17 Coronary Artery Disease 5p and hsa-miR-99a-5p) consistently upregulated by greater than twofold in groups with CAD. +other 33126452 hsa-mir-99a Coronary Artery Disease 5p and hsa-miR-99a-5p) consistently upregulated by greater than twofold in groups with CAD. +other 33126452 hsa-mir-21 Coronary Artery Disease 5p and hsa-miR-99a-5p) consistently upregulated by greater than twofold in groups with CAD. +other 33126129 hsa-mir-27a Triple Negative Breast Neoplasms HMGA1 was the top ranked hub in mesenchymal subtype associated lung metastasis, while hsa-miR-27a-3p was identified as the top ranked hub mRNA in luminal androgen receptor subtype associated bone metastasis. +circulation_biomarker_diagnosis_ns 33126129 hsa-mir-29c Triple Negative Breast Neoplasms When lncRNA associated pathway analysis was performed, Hs Cytoplasmic Ribosomal Protein pathway was found to be the most significant and among the selected hubs, CTNND1, SON and hsa-miR-29c emerged as TNBC survival markers. +genetics_overexpression_promote 33126007 hsa-mir-30 Leukemia, Myeloid, Acute 5p directly interacted with FOXM1 messenger RNA (mRNA), and FOXM1 overexpression partly reversed miR +other 33125867 hsa-mir-51 Embryo Loss Using a Microprocessor-bypass strategy, we show that this early embryonic arrest is rescued by the addition of just two miRNAs, one miR-35 and one miR-51 family member, resulting in morphologically normal larvae. +other 33125867 hsa-mir-5 Embryo Loss Using a Microprocessor-bypass strategy, we show that this early embryonic arrest is rescued by the addition of just two miRNAs, one miR-35 and one miR-51 family member, resulting in morphologically normal larvae. +lncRNA target 33125858 hsa-mir-103a Osteoarthritis In conclusion, our findings highlight a novel protective role of circPDE4D in OA pathogenesis and indicate that the targeting of the circPDE4D-miR-103a-3p-FGF18 axis might provide a potential and promising approach for OA therapy. +tissue_expression_ns 33125780 hsa-mir-7 Hepatitis, Autoimmune APPROACH AND RESULTS Herein, we showed that miR-7 deficiency led to exacerbated pathology in Concanavalin-A-induced murine acute autoimmune liver injury (ALI) model, accompanied by hyperactivation state of CD4+ T cells. CONCLUSIONS This study expands on the important role of miR-7 in liver-related diseases and reveals the value of the C/EBP/miR-7 axis in CD4+ T-cell biological function for the pathogenesis of immune-mediated liver diseases. +transcription factor target 33125708 hsa-mir-200c Neointimal Hyperplasia Our findings offer a novel therapeutic opportunity for treating vascular diseases by specifically targeting the miR-200c-3p/FERM2 regulatory axis. +genetics_overexpression_promote 33125611 hsa-mir-20a Carcinoma, Non-Small-Cell Lung Overexpressed miR-20a not only dramatically suppressed NSCLC cells proliferation, endothelial cells migration and tube formation in vitro, but also inhibited tumor growth and angiogenesis in vivo. +genetics_overexpression_promote 33125503 hsa-mir-487b Osteosarcoma Taken together, the results from the present study suggests that miR487b3p is a tumor suppressor and that the overexpression of miR487b3p is a novel strategy to inhibit tumor metastasis and chemoresistance in OS. +lncRNA target 33125461 hsa-mir-155 Memory Disorders CONCLUSION: The present study sheds light on the potential neuroprotective effects of alogliptin against intracerebroventricular LPS-induced neuroinflammation and its associated memory impairment via inhibition of toll-like receptor 4/ myeloid differentiation primary response 88/ nuclear factor-kappaB signaling, modulation of microRNA-155/suppressor of cytokine signaling-1 expression, and enhancement of cAMP/phosphorylated cAMP response element binding protein signaling. +lncRNA target 33125461 hsa-mir-155 Neurogenic Inflammation CONCLUSION: The present study sheds light on the potential neuroprotective effects of alogliptin against intracerebroventricular LPS-induced neuroinflammation and its associated memory impairment via inhibition of toll-like receptor 4/ myeloid differentiation primary response 88/ nuclear factor-kappaB signaling, modulation of microRNA-155/suppressor of cytokine signaling-1 expression, and enhancement of cAMP/phosphorylated cAMP response element binding protein signaling. +lncRNA target 33125430 hsa-mir-20a Carcinoma, Non-Small-Cell Lung In addition, the regulation of tumor-promoting cytokine, through miR-20a and miR-223, might be a new therapeutic approach for lung cancer. +circulation_biomarker_diagnosis_up 33125430 hsa-mir-145 Carcinoma, Non-Small-Cell Lung In the clinical validation, serum miR-145 was significantly down-regulated, whereas serum miR-20a was significantly up-regulated in NSCLC, compared with controls. MiR-145 and miR-20a are potential biomarkers for NSCLC. +lncRNA target 33125430 hsa-mir-223 Carcinoma, Non-Small-Cell Lung In addition, the regulation of tumor-promoting cytokine, through miR-20a and miR-223, might be a new therapeutic approach for lung cancer. +circulation_biomarker_prognosis_ns 33125362 hsa-mir-21 Lung Neoplasms BACKGROUND The goal of the present study was to explore the influence of whole-brain radiotherapy (WBRT) and intensity-modulated radiotherapy (IMRT) on serum levels of miR-21 and prognosis for lung cancer that has metastasized to the brain. Low levels of miR-21 were associated with longer overall survival in patients with lung cancer metastatic to the brain. +lncRNA target 33125151 hsa-mir-505 Glioma Taken together, the results from the present provided novel insights into the roles of KTN1AS1 in GBM, and suggested that the KTN1AS1/miR5053p axis may be considered as a novel therapeutic target for the treatment of patients with GBM. +genetics_overexpression_promote 33125147 hsa-mir-138 Glioma In addition, cAMP response elementbinding protein 1 (CREB1) was confirmed as a direct target gene of miR138 by luciferase gene reporter assay, and the antitumour effect of miR138 on glioma cells was significantly reversed by CREB1 overexpression. +genetics_overexpression_promote 33125142 hsa-mir-7 Carcinoma, Non-Small-Cell Lung In conclusion, SP1 was a target of miR7, and the decreased expression of SP1 resulting from miR7 overexpression in NSCLC was vital for improving radiosensitivity in NSCLC cells. +lncRNA target 33125117 hsa-mir-132 Lung Neoplasms To the best of our knowledge, the present study demonstrated for the first time that the administration of hesperidin decreased the expression of ZEB2 by upregulating the expression of miR132, which in turn promoted apoptosis and inhibited the proliferation of NSCLC cells. +lncRNA target 33125110 hsa-mir-1271 Colonic Neoplasms Mechanistically, it was demonstrated that lncRNA RP11619L19.2 played an oncogenic role and promoted CC development and metastasis by regulating the miR12715p/CD164 axis and EMT. In conclusion, the findings of the present study indicated that RP11619L19.2 regulates CD164 expression and EMT by sponging miR12715p, which may provide novel targets for lncRNAdirected diagnosis and therapy for patients with CC. +circulation_biomarker_diagnosis_down 33125105 hsa-mir-199a Inflammation miR199a3p was found to be significantly downregulated in the peripheral blood samples, and there was a negative correlation between miR199a3p expression and proteinuria in patients with DN. +circRNA target 33125098 hsa-mir-140 Short Stature, Idiopathic, Autosomal Taken together, chondrocyte proliferation, hypertrophy and endochondral ossification in ISS was suppressed by a novel regulatory axis consisting of the hsa_circRNA_0079201/miR1403p/SMAD2 pathway. +lncRNA target 33125097 hsa-mir-654 Esophageal Squamous Cell Carcinoma Mechanistically, LINC01232 was shown to function as an microRNA6543p (miR6543p) sponge in ESCC cells, and hepatomaderived growth factor (HDGF) was identified as a direct target of miR6543p. +exosome 33125091 hsa-mir-34a Colonic Neoplasms miR34a5p was a target of circHMGCS1 and miR34a5p inhibition reversed the effect of circHMGCS1 silencing on colon cancer cell progression. In conclusion, sevoflurane inhibited colon cancer progression by modulating the exosometransmitted circHMGCS1/miR34a5p/SGPP1 axis. +other 33125090 hsa-mir-202 Endometriosis The expression of miR202 and KRas in eutopic and ectopic endometrioma tissues were detected using reverse transcriptionquantitative PCR, immunohistochemistry and western blotting. +transcription factor target 33125090 hsa-mir-202 Moebius syndrome 1 Compared with that from healthy individuals, miR202 expression was demonstrated to be lower in the eutopic endometrium from patients with EMS, which was even lower in ectopic endometrium. These findings suggested that miR202 inhibited ESC migration and invasion by inhibiting the KRas/Raf1/MEK/ERK signaling pathway, rendering miR202 a candidate for being a therapeutic target for EMS. +genetics_overexpression_promote 33125088 hsa-mir-20a Liver Cirrhosis The RSVtreated HSCT6 cells were subjected to transfection with miR20a mimic and PTEN overexpression plasmid to assess the levels of liver injury and LF. +genetics_overexpression_suppress 33125087 hsa-mir-140 Colorectal Neoplasms The use of an autophagy inducer partially reversed the miR3140 overexpressioninduced inhibition of the viability and invasion, and the promotion of the apoptosis of hypoxiaexposed CRC cells. +lncRNA target 33125086 hsa-mir-204 Diabetes Mellitus Furthermore, the regulatory mechanisms of TUG1/SIRT1 and miR204 in the development of diabetes were also explored. On the whole, the findings of the present study demonstrate that lncRNA TUG1 significantly reverses the development of diabetes by downregulating the expression of miR204, and upregulating its targeted SIRT1/AMPK/ACC signaling pathway. +lncRNA target 33125052 hsa-mir-155 Thymus Neoplasms Mechanistically, we show that RANKL stimulation induces expression of miR-155 to safeguard the thymic medulla through targeting multiple known and previously uncharacterized molecules within the TGFbeta signaling pathway, which is recognized for its role in restricting the maturation and expansion of mTECs. +other 33124206 hsa-let-7a Aggressive Periodontitis RESULTS: Four downregulated miRNAs (hsa-let-7a-5p, hsa-let-7f-5p, hsa-miR-181b-5p, and hsa-miR-23b-3p) were identified in patients with AP. +other 33124206 hsa-mir-181b Aggressive Periodontitis RESULTS: Four downregulated miRNAs (hsa-let-7a-5p, hsa-let-7f-5p, hsa-miR-181b-5p, and hsa-miR-23b-3p) were identified in patients with AP. +other 33124206 hsa-mir-23b Aggressive Periodontitis RESULTS: Four downregulated miRNAs (hsa-let-7a-5p, hsa-let-7f-5p, hsa-miR-181b-5p, and hsa-miR-23b-3p) were identified in patients with AP. +other 33124206 hsa-let-7f Aggressive Periodontitis RESULTS: Four downregulated miRNAs (hsa-let-7a-5p, hsa-let-7f-5p, hsa-miR-181b-5p, and hsa-miR-23b-3p) were identified in patients with AP. +genetics_GWAS 33124182 hsa-mir-126 Diabetes Mellitus, Type 1 The purpose of this study was to investigate the association between miR-126 rs4636297 (G/A) and miR-146a rs2910164 (G/C) miRSNPs and DR. CONCLUSION: Our results suggest an association between the A allele of miR-126 rs4636297 miRSNP and protection for DR in a Southern Brazilian population. +genetics_GWAS 33124182 hsa-mir-126 Diabetic Retinopathy The purpose of this study was to investigate the association between miR-126 rs4636297 (G/A) and miR-146a rs2910164 (G/C) miRSNPs and DR. CONCLUSION: Our results suggest an association between the A allele of miR-126 rs4636297 miRSNP and protection for DR in a Southern Brazilian population. +other 33124182 hsa-mir-146a Diabetes Mellitus, Type 1 MiRNA-126 and miRNA-146a have been described as having abnormal expressions in diabetic retinopathy (DR) patients. +other 33124182 hsa-mir-146a Diabetic Retinopathy MiRNA-126 and miRNA-146a have been described as having abnormal expressions in diabetic retinopathy (DR) patients. +circulation_biomarker_diagnosis_ns 33124175 hsa-mir-371a Nonseminomatous germ cell tumor The model compared outcomes and cost of standard approach using histopathology, conventional serum tumour markers and radiographic staging (standard model) to a miRNA-based approach using the standard model post-orchidectomy serum miR-371a-3p (marker model). +other 33123932 hsa-mir-23a Macular Degeneration RESULTS: The retinal pigment epithelial (RPE) cells (ARPE-19) were subjected to hydrogen peroxide (H(2)O(2)) stimulation to simulate AMD progression in vitro, and we identified a novel miR-23a/glutaminase-1 (GLS1) pathway that regulated H(2)O(2) induced oxidative damages in ARPE-19 cells. CONCLUSIONS: In general, analysis of the data suggested that miR-23a ablation upregulated GLS1 to attenuate H(2)O(2) stimulation induced oxidative damages in ARPE-19 cells in vitro, and this study broadened our knowledge in this field, which might help to provide novel theranostic signatures for AMD. +other 33123872 hsa-mir-1236 Endometrial Neoplasms 5p were differentially expressed in endometrial cancer in comparison to the control. +other 33123872 hsa-mir-873 Endometrial Neoplasms 5p were differentially expressed in endometrial cancer in comparison to the control. +other 33123872 hsa-mir-548 Endometrial Neoplasms 5p were differentially expressed in endometrial cancer in comparison to the control. +other 33123872 hsa-mir-340 Endometrial Neoplasms 5p were differentially expressed in endometrial cancer in comparison to the control. +other 33123872 hsa-mir-874 Endometrial Neoplasms Among the distinguished miRNAs, the most promising is mir3p, which may have an important role in endometrial adenocarcinoma proliferation. +transcription factor target 33123835 hsa-mir-125b Lyme Disease Thus, the present findings suggested that miR-125b-5p could regulate LDD by adjusting NP cell apoptosis and inflammatory responses via TRIAP1. +transcription factor target 33123835 hsa-mir-125b Intervertebral Disc Degeneration TRIAP1, which directly targets miR-125b-5p, was markedly downregulated in human lumbar degenerative NP specimens and IL-1beta-treated NP cells. +exosome 33123829 hsa-mir-515 Stomach Neoplasms CONCLUSIONS: Exosomal circ_0032821 boosted OXA resistance of GC cells partly by the miR5p/SOX9 axis, hinting a promising therapeutic target for GC treatment. +circulation_biomarker_diagnosis_up 33123597 hsa-mir-518d Diabetes, Gestational METHODS: Placenta tissues and peripheral plasma were obtained from pregnant women with normal pregnancy and GDM, respectively, followed by the detections of miR-518d contents by RT-PCR and the expression levels of inflammatory factors using ELISA. +transcription factor target 33123586 hsa-mir-21 high grade glioma Currently, miR-21 and CXCR4 are being extensively investigated as two key regulators in glioma malignancy. Inhibition of miR-21, CXCR4, and miR-21 and CXCR4 together all reduced the migration, invasiveness, proliferation, and enhanced apoptosis in glioma cells, as well as reduced tumor volume and mass in xenograft model. +transcription factor target 33123581 hsa-mir-425 Carcinoma, Hepatocellular 5p as an oncogene promotes the malignant development of HCC via RNF11 and serves as a molecular target for predicting the prognosis of HCC patients. +lncRNA target 33123543 hsa-mir-12462 Leukemia, Myeloid, Acute In summary, a higher level of hsa-miR-12462 in AML cells is associated with increased sensitivity to Ara-C via targeting FosB. +other 33123477 hsa-mir-888 Rectal Neoplasms MiR-302a, miR-105, and miR-888 have potential influence on the pathogenesis, RT, and prognosis of rectal cancer. +other 33123476 hsa-mir-1324 Esophageal Neoplasms MiR-1324 upregulation resulted in decreased GDF15 expression and metastasis in ESCCs. +transcription factor target 33123457 hsa-mir-505 Uterine Cervical Neoplasms miR-505 targeted AKT2, which was upregulated in CC. +other 33123297 hsa-mir-105 Leukemia, Myeloid, Acute Long non-coding RNA GHET1/miR-105/RAP2B axis regulates the progression of acute myeloid leukemia. +other 33123295 hsa-mir-425 Ovarian Neoplasms 5p-FUT8-AS1 and CXCR4-hsa-miR-146a-5p-LINC00665/LINC01535) were eventually constructed in OC based on ceRNA mechanism. +other 33123295 hsa-mir-146a Ovarian Neoplasms 5p-FUT8-AS1 and CXCR4-hsa-miR-146a-5p-LINC00665/LINC01535) were eventually constructed in OC based on ceRNA mechanism. +circulation_biomarker_diagnosis_ns 33123293 hsa-mir-4644 Carcinoma, Hepatocellular Conclusions: Our findings demonstrated that miR-4644 is an ideal endogenous normalizer for circulating microRNA quantification in hepatocellular carcinoma. +genetics_overexpression_suppress 33123285 hsa-mir-637 Carcinoma, Hepatocellular Moreover, overexpression of USP21 or silencing of miR-637 restored the inhibitory impacts of hsa_circ_0039053 silencing on HCC progression. Collectively, our study confirmed that hsa_circ_0039053 could be regarded as a competing endogenous RNA (ceRNA) to positively modulate the expression of USP21 combining with miR-637, which provided a potential target in HCC treatment. +target gene 33123264 hsa-mir-155 Prostatic Neoplasms MicroRNA-155-5p inhibits the invasion and migration of prostate cancer cells by targeting SPOCK1. +circulation_biomarker_diagnosis_ns 33123261 hsa-mir-1246 Esophageal Squamous Cell Carcinoma The current study assessed the role of miR-1246 and miR-106b in the serum of patients with esophageal squamous cell carcinoma (ESCC). +circulation_biomarker_diagnosis_ns 33123261 hsa-mir-106b Esophageal Squamous Cell Carcinoma The current study assessed the role of miR-1246 and miR-106b in the serum of patients with esophageal squamous cell carcinoma (ESCC). +target gene 33123250 hsa-mir-451a Multiple Myeloma miR-451a suppression of IL-6R can inhibit proliferation and increase apoptosis through the JAK2/STAT3 pathway in multiple myeloma. +other 33123249 hsa-mir-214 Ovarian Neoplasms, High-Grade Serous Furthermore, downregulation of miRNA3p in isolated cancer glands and downregulation of miRNA-320c in the corresponding stromal tissue were associated with a decrease in disease-free survival (without recurrence) in cohort 2. +other 33123249 hsa-mir-320c Ovarian Neoplasms, High-Grade Serous Furthermore, downregulation of miRNA3p in isolated cancer glands and downregulation of miRNA-320c in the corresponding stromal tissue were associated with a decrease in disease-free survival (without recurrence) in cohort 2. +transcription factor target 33123240 hsa-mir-142 nonpapillary renal cell carcinoma 5p as a biomarker and a therapeutic target provides rationale for further investigation into miR +lncRNA target 33123239 hsa-mir-101 Melanoma 3p/RAP2B signaling pathway may be a novel therapeutic target for melanoma. +other 33122952 hsa-mir-520d Ovarian Neoplasms Long Non-Coding RNA USP2-AS1 Accelerates Cell Proliferation and Migration in Ovarian Cancer by Sponging miR-520d-3p and Up-Regulating KIAA1522. +target gene 33122950 hsa-mir-29b Osteosarcoma LncRNA CCAL Promotes Angiogenesis Through Regulating the MiR-29b/ANGPTL4 Axis in Osteosarcoma. +circRNA target 33122949 hsa-mir-129 gastric adenocarcinoma CONCLUSION: Circ_0000260 regulated CDDP chemoresistance of GAC by promoting MMP11 expression via targeting miR5p. +genetics_overexpression_promote 33122931 hsa-mir-145 Diabetic Nephropathies 5p overexpression and reduces TLR4/MyD88/NF-kappaB (p65) pathway activation in vitro and in vivo. +genetics_overexpression_promote 33122920 hsa-mir-935 Glioma Similarly, HIF1alpha overexpression remarkably reversed the inhibitory effects of miR-935 on the proliferation, migration and invasion of glioma cells. +lncRNA target 33122919 hsa-mir-16 Glioblastoma DISCUSSION: MicroRNA-16 exhibits inhibitory effects of glioblastoma. +circulation_biomarker_diagnosis_up 33122915 hsa-mir-149 Carcinoma, Renal Cell 5p were significantly downregulated in the plasma exosomes of RCC. +circulation_biomarker_diagnosis_up 33122915 hsa-mir-424 Carcinoma, Renal Cell 5p were significantly downregulated in the plasma exosomes of RCC. +circulation_biomarker_diagnosis_up 33122915 hsa-mir-92a-1 Carcinoma, Renal Cell 5p were significantly downregulated in the plasma exosomes of RCC. +exosome 33122828 hsa-mir-139 Urinary Bladder Neoplasms These data together supported the tumor-inhibiting role of MSCs-derived exosomal miR +other 33122632 hsa-mir-200b Wounds and Injuries TGF-1 induction attenuated miR-200b/c-3p regulation of RAC1 signaling in cutaneous wounds and the repression of miR-200b/c-3p accelerated keratinocyte migration to promote wound healing. +other 33122632 hsa-mir-200c Wounds and Injuries TGF-1 induction attenuated miR-200b/c-3p regulation of RAC1 signaling in cutaneous wounds and the repression of miR-200b/c-3p accelerated keratinocyte migration to promote wound healing. +transcription factor target 33122522 hsa-mir-1 Dementia, Vascular CONCLUSIONS: Necrosis in L-arginine-induced SAP is promoted by CHRM3 through the mitogen-activated protein kinase-p38/miR +transcription factor target 33122522 hsa-mir-1 Necrosis CONCLUSIONS: Necrosis in L-arginine-induced SAP is promoted by CHRM3 through the mitogen-activated protein kinase-p38/miR5p/RIP3 axis. +genetics_overexpression_suppress 33122459 hsa-mir-191 Squamous Cell Carcinoma of Head and Neck CONCLUSION: The findings of this study demonstrate that overexpression of miR-155, miR-191, and miR-494 is associated with OSCC, and Avastin is able to regulate and downregulate the expression of those biomarkers and increase apoptosis in cancerous cells in the HN5 cell line. +genetics_overexpression_suppress 33122459 hsa-mir-494 Squamous Cell Carcinoma of Head and Neck CONCLUSION: The findings of this study demonstrate that overexpression of miR-155, miR-191, and miR-494 is associated with OSCC, and Avastin is able to regulate and downregulate the expression of those biomarkers and increase apoptosis in cancerous cells in the HN5 cell line. +genetics_overexpression_suppress 33122459 hsa-mir-155 Squamous Cell Carcinoma of Head and Neck CONCLUSION: The findings of this study demonstrate that overexpression of miR-155, miR-191, and miR-494 is associated with OSCC, and Avastin is able to regulate and downregulate the expression of those biomarkers and increase apoptosis in cancerous cells in the HN5 cell line. +exosome 33122449 hsa-mir-613 Esophageal Neoplasms Furthermore, exosomal UCA1 could directly target miRNA-613 in esophageal cancer cells. +lncRNA target 33122398 hsa-mir-200a Nasopharyngeal Carcinoma RESULT: A novel molecular mechanism was identified that involves EBV-EBNA1-stimulated chemotactic migration of Treg cells toward NPC microenvironment by upregulation of the transforming growth factor-beta1 (TGFbeta1)-SMAD3-PI3K-AKT-c-JUN-CXCL12-CXCR4 axis and downregulation of miR-200a. CONCLUSIONS: EBV-EBNA1 promotes chemotactic migration of Treg cells via the TGFbeta1-SMAD3-PI3K-AKT-c-JUN-miR-200a-CXCL12-CXCR axis in the NPC microenvironment. +genetics_knock down_promote 33121976 hsa-mir-642a Uterine Cervical Neoplasms Taken together, our data indicated that knockdown of PCGEM1 inhibited proliferation, migration and invasion in cervical carcinoma by modulating the miR-642a-5p/ LGMN axis. +other 33121682 hsa-mir-376a Laryngeal Neoplasms Finally, autophagy-related gene ATG2A was shown to rescue miR-376a-modulated drug resistance of laryngocarcinoma cells. +circulation_biomarker_diagnosis_up 33121529 hsa-mir-224 ST Elevation Myocardial Infarction After adjustment with sex, age, diabetes mellitus, and plasma PTX3 concentration, miR +circulation_biomarker_diagnosis_ns 33121529 hsa-mir-155 ST Elevation Myocardial Infarction 5p expressions with plasma PTX3 concentration and coronary microvascular obstruction (MVO) in patients with acute ST-segment elevation myocardial infarction (STEMI) with symptom onset . +circulation_biomarker_diagnosis_ns 33112562 hsa-mir-29a Colorectal Neoplasms CONCLUSION: Serum levels of miR-21, miR-29a and miR-92a were able to significantly detect early stage CRC in a multiethnic and previously untested population.
. +circulation_biomarker_diagnosis_ns 33112562 hsa-mir-92a Colorectal Neoplasms CONCLUSION: Serum levels of miR-21, miR-29a and miR-92a were able to significantly detect early stage CRC in a multiethnic and previously untested population.
. +other 33112535 hsa-mir-21 Hematologic Diseases Compared with controls, the levels of miR-21 were significantly upregulated in BMF of patients with leukemia but not lymphoma. CONCLUSIONS: Collectively, using spiked-in RNA as a reference the upregulated miR-21 levels in BMF could be an indicator of the diagnosis of leukemia and a predictor of mortality. +circulation_biomarker_diagnosis_ns 33112434 hsa-mir-218 Squamous Intraepithelial Lesions The expression of circulating microRNAs miR-15b, miR-34a and miR-218 in patients with LSILs was compared to 23 HPV-negative individuals showing normal cervical epithelium (healthy women) and 23 Squamous Cell Carcinoma (SCC) samples. +circulation_biomarker_diagnosis_ns 33112434 hsa-mir-34a Leigh Disease The expression of circulating microRNAs miR-15b, miR-34a and miR-218 in patients with LSILs was compared to 23 HPV-negative individuals showing normal cervical epithelium (healthy women) and 23 Squamous Cell Carcinoma (SCC) samples. +circulation_biomarker_diagnosis_ns 33112434 hsa-mir-218 Carcinoma, Squamous Cell The expression of circulating microRNAs miR-15b, miR-34a and miR-218 in patients with LSILs was compared to 23 HPV-negative individuals showing normal cervical epithelium (healthy women) and 23 Squamous Cell Carcinoma (SCC) samples. +circulation_biomarker_diagnosis_ns 33112434 hsa-mir-15b Squamous Intraepithelial Lesions The expression of circulating microRNAs miR-15b, miR-34a and miR-218 in patients with LSILs was compared to 23 HPV-negative individuals showing normal cervical epithelium (healthy women) and 23 Squamous Cell Carcinoma (SCC) samples. The expression levels of miR-15b remained unchanged while those of miRNAs 34a and 218 were relatively high in serum obtained from LSIL patients in comparison with healthy women (results were statistically significant with a p of < 0.01 or < 0.001). +circulation_biomarker_diagnosis_ns 33112434 hsa-mir-15b Leigh Disease The expression of circulating microRNAs miR-15b, miR-34a and miR-218 in patients with LSILs was compared to 23 HPV-negative individuals showing normal cervical epithelium (healthy women) and 23 Squamous Cell Carcinoma (SCC) samples. +circulation_biomarker_diagnosis_ns 33112434 hsa-mir-218 Leigh Disease The expression of circulating microRNAs miR-15b, miR-34a and miR-218 in patients with LSILs was compared to 23 HPV-negative individuals showing normal cervical epithelium (healthy women) and 23 Squamous Cell Carcinoma (SCC) samples. +circulation_biomarker_diagnosis_ns 33112434 hsa-mir-34a Squamous Intraepithelial Lesions The expression of circulating microRNAs miR-15b, miR-34a and miR-218 in patients with LSILs was compared to 23 HPV-negative individuals showing normal cervical epithelium (healthy women) and 23 Squamous Cell Carcinoma (SCC) samples. The expression levels of miR-15b remained unchanged while those of miRNAs 34a and 218 were relatively high in serum obtained from LSIL patients in comparison with healthy women (results were statistically significant with a p of < 0.01 or < 0.001). +lncRNA target 33112352 hsa-mir-21 Myocardial Infarction, Acute MicroRNA-21(miR-21) contributes to the pathophysiological consequences of acute myocardial infarction by targeting downstream crucial regulators. Thus, miR-21 mimics are a promising strategy for the treatment of AMI. +circulation_biomarker_diagnosis_ns 33112286 hsa-mir-483 Hypoglycemia CONCLUSION: The associations of serum miR +lncRNA target 33112219 hsa-mir-17 Lymphoproliferative Disorders In addition, immunosuppression-associated diseases such as squamous cell carcinoma, posttransplant lymphoproliferative disorders, and aspergillosis, which are encountered clinically, were found to correlate with expression changes in microRNAs such as miR +lncRNA target 33112219 hsa-mir-150 Immune System Diseases In addition, immunosuppression-associated diseases such as squamous cell carcinoma, posttransplant lymphoproliferative disorders, and aspergillosis, which are encountered clinically, were found to correlate with expression changes in microRNAs such as miR +lncRNA target 33112219 hsa-mir-20a Immune System Diseases In addition, immunosuppression-associated diseases such as squamous cell carcinoma, posttransplant lymphoproliferative disorders, and aspergillosis, which are encountered clinically, were found to correlate with expression changes in microRNAs such as miR +lncRNA target 33112219 hsa-mir-17 Aspergillosis In addition, immunosuppression-associated diseases such as squamous cell carcinoma, posttransplant lymphoproliferative disorders, and aspergillosis, which are encountered clinically, were found to correlate with expression changes in microRNAs such as miR +lncRNA target 33112219 hsa-mir-150 Aspergillosis In addition, immunosuppression-associated diseases such as squamous cell carcinoma, posttransplant lymphoproliferative disorders, and aspergillosis, which are encountered clinically, were found to correlate with expression changes in microRNAs such as miR +lncRNA target 33112219 hsa-mir-21 Aspergillosis In addition, immunosuppression-associated diseases such as squamous cell carcinoma, posttransplant lymphoproliferative disorders, and aspergillosis, which are encountered clinically, were found to correlate with expression changes in microRNAs such as miR +lncRNA target 33112219 hsa-mir-150 Carcinoma, Squamous Cell In addition, immunosuppression-associated diseases such as squamous cell carcinoma, posttransplant lymphoproliferative disorders, and aspergillosis, which are encountered clinically, were found to correlate with expression changes in microRNAs such as miR +lncRNA target 33112219 hsa-mir-20a Lymphoproliferative Disorders In addition, immunosuppression-associated diseases such as squamous cell carcinoma, posttransplant lymphoproliferative disorders, and aspergillosis, which are encountered clinically, were found to correlate with expression changes in microRNAs such as miR +lncRNA target 33112219 hsa-mir-150 Lymphoproliferative Disorders In addition, immunosuppression-associated diseases such as squamous cell carcinoma, posttransplant lymphoproliferative disorders, and aspergillosis, which are encountered clinically, were found to correlate with expression changes in microRNAs such as miR +lncRNA target 33112219 hsa-mir-20a Aspergillosis In addition, immunosuppression-associated diseases such as squamous cell carcinoma, posttransplant lymphoproliferative disorders, and aspergillosis, which are encountered clinically, were found to correlate with expression changes in microRNAs such as miR +lncRNA target 33112219 hsa-mir-607 Lymphoproliferative Disorders In addition, immunosuppression-associated diseases such as squamous cell carcinoma, posttransplant lymphoproliferative disorders, and aspergillosis, which are encountered clinically, were found to correlate with expression changes in microRNAs such as miR +lncRNA target 33112219 hsa-mir-607 Aspergillosis In addition, immunosuppression-associated diseases such as squamous cell carcinoma, posttransplant lymphoproliferative disorders, and aspergillosis, which are encountered clinically, were found to correlate with expression changes in microRNAs such as miR +lncRNA target 33112219 hsa-mir-20a Carcinoma, Squamous Cell In addition, immunosuppression-associated diseases such as squamous cell carcinoma, posttransplant lymphoproliferative disorders, and aspergillosis, which are encountered clinically, were found to correlate with expression changes in microRNAs such as miR +lncRNA target 33112219 hsa-mir-17 Immune System Diseases In addition, immunosuppression-associated diseases such as squamous cell carcinoma, posttransplant lymphoproliferative disorders, and aspergillosis, which are encountered clinically, were found to correlate with expression changes in microRNAs such as miR +lncRNA target 33112219 hsa-mir-21 Carcinoma, Squamous Cell In addition, immunosuppression-associated diseases such as squamous cell carcinoma, posttransplant lymphoproliferative disorders, and aspergillosis, which are encountered clinically, were found to correlate with expression changes in microRNAs such as miR +lncRNA target 33112219 hsa-mir-607 Immune System Diseases In addition, immunosuppression-associated diseases such as squamous cell carcinoma, posttransplant lymphoproliferative disorders, and aspergillosis, which are encountered clinically, were found to correlate with expression changes in microRNAs such as miR +lncRNA target 33112219 hsa-mir-21 Lymphoproliferative Disorders In addition, immunosuppression-associated diseases such as squamous cell carcinoma, posttransplant lymphoproliferative disorders, and aspergillosis, which are encountered clinically, were found to correlate with expression changes in microRNAs such as miR +lncRNA target 33112219 hsa-mir-17 Carcinoma, Squamous Cell In addition, immunosuppression-associated diseases such as squamous cell carcinoma, posttransplant lymphoproliferative disorders, and aspergillosis, which are encountered clinically, were found to correlate with expression changes in microRNAs such as miR +lncRNA target 33112219 hsa-mir-21 Immune System Diseases In addition, immunosuppression-associated diseases such as squamous cell carcinoma, posttransplant lymphoproliferative disorders, and aspergillosis, which are encountered clinically, were found to correlate with expression changes in microRNAs such as miR +lncRNA target 33112219 hsa-mir-607 Carcinoma, Squamous Cell In addition, immunosuppression-associated diseases such as squamous cell carcinoma, posttransplant lymphoproliferative disorders, and aspergillosis, which are encountered clinically, were found to correlate with expression changes in microRNAs such as miR +lncRNA target 33111745 hsa-mir-134 Pre-Eclampsia FAM99A modulated YAP1 to accelerate cell migration and invasion, and inhibited cell apoptosis in PE cells by sponging miR +transcription factor target 33111654 hsa-mir-206 Carcinoma, Hepatocellular UTMD-mediated miR-206 inhibited HCC cell migration and invasion while promoting apoptosis via regulating the expressions of proteins related to apoptosis, migration, and invasion by targeting PPIB. +lncRNA target 33111649 hsa-mir-103a Stomach Neoplasms NEAT1 was targeted and inhibited by miR-103a and acted as an oncogene, which promoted the malignant behavior of GC cells. +other 33111613 hsa-mir-22 Stomach Neoplasms We identified a novel MYC/miR3p/PHF8 regulatory axis in GC. +lncRNA target 33111515 hsa-mir-28 Colorectal Neoplasms 3p inhibitor promoted the proliferation in CRC cells. +lncRNA target 33111341 hsa-mir-582 Osteoporosis Finally, our findings manifested that the positive feedback loop of SNHG5/miR5p/RUNX3 executed the promoting role in the development of osteoporosis, which shed light on specific molecular mechanism governing SNHG5 in osteogenic differentiation and apoptosis of hBMSCs and indicated that SNHG5 may represent a novel target for the improvement of osteoporosis therapy. +lncRNA target 33111281 hsa-mir-29b Hypoxia-Ischemia, Brain CONCLUSION: H19 improved the brain tissue and alleviated nerve damage of neonatal HIE rats by upregulating the Akt3/mTOR pathway as a miR-29b sponge. H19 reduces autophagy in neonatal HIE rats by the miR-29b/Akt3/mTOR axis.. +exosome 33110923 hsa-mir-21 Endometrial Neoplasms In summary, we found that endometrial cancer KEL cells in hypoxic condition promoted monocyte THP-1 cell transformation to M2-like polarization macrophages through delivering exosomal miRNA-21, which may be a potential mechanism of the formation of the immune microenvironment in EC progression. +exosome 33110474 hsa-mir-199a Glioma Moreover, the upregulation of miRNA-199a-3p in exosomes from glioma cells was induced by hypoxia-related HIF-1alpha activation. To sum up, hypoxia-induced glioma-derived exosomal miRNA-199a-3p can be upregulated by the activation of HIF-1alpha and is able to increase the ischemic injury of peritumoral neurons by inhibiting the mTOR pathway. +exosome 33110474 hsa-mir-199a Brain Ischemia Moreover, the upregulation of miRNA-199a-3p in exosomes from glioma cells was induced by hypoxia-related HIF-1alpha activation. To sum up, hypoxia-induced glioma-derived exosomal miRNA-199a-3p can be upregulated by the activation of HIF-1alpha and is able to increase the ischemic injury of peritumoral neurons by inhibiting the mTOR pathway. +other 33110451 hsa-mir-28 Glioma LINC00210 exerts oncogenic roles in glioma by sponging miR-328. +genetics_overexpression_promote 33109774 hsa-mir-382 Osteosarcoma Bioinformatics analysis and clinical experiments confirmed that LINC00265, SAT1 and VAV3 were overexpressed in osteosarcoma and related to a poor prognosis, whereas miR +exosome 33109773 hsa-mir-1286 Uterine Cervical Neoplasms Finally, we found that circRNA_PVT1 can induce EMT of cervical cancer cells via targeting miR-1286 by exosome pathway, which can be a novel mechanism of cervical cancer progression. +lncRNA target 33109602 hsa-mir-200c Osteoarthritis Mechanistically, miR-141/200c promotes OA by targeting SIRT1, which acetylates histone in the promoters of interleukin 6 (IL-6), thereby activating IL-6/STAT3 pathway. +lncRNA target 33109602 hsa-mir-141 Osteoarthritis Mechanistically, miR-141/200c promotes OA by targeting SIRT1, which acetylates histone in the promoters of interleukin 6 (IL-6), thereby activating IL-6/STAT3 pathway. +lncRNA target 33109569 hsa-mir-143 Osteosarcoma RESULTS: The cytotoxicity and migration-inhibitory effects of rVSV-miR143 on the osteosarcoma cells were significantly higher than those of VSV alone at a dose of 5x10(-4) multiplicity of infection, indicating that rVSV-miRNA143 enhances the antitumor effect at certain doses. CONCLUSION: VSV incorporating tumor-suppressor miRNA143 demonstrated a synergistic antitumor effect on osteosarcoma cells in vitro. +lncRNA target 33109562 hsa-mir-1 Stomach Neoplasms CONCLUSION: High LITAF expression resulting from low miR3p expression is a biomarker for poor prognosis or therapeutic targets in gastric cancer. +transcription factor target 33109548 hsa-mir-935 Squamous Cell Carcinoma of Head and Neck CONCLUSION: miR-935 may function as a tumor suppressor by inhibiting OSCC malignancy via INPP4A induction. +lncRNA target 33109341 hsa-mir-485 Adenocarcinoma of Lung CONCLUSION: SNHG17 triggers the progression of LUAD via sponging miR +transcription factor target 33109304 hsa-mir-548m Breast Neoplasms Taken together, our findings suggest a novel function of miR-548m in reversing the EMT of breast cancer by reducing their migratory and invasive potentials, at least in part via targeting AHR expression. +genetics_overexpression_promote 33109266 hsa-mir-375 Uterine Cervical Neoplasms Overexpression of miR-375 suppressed proliferation, migration, and invasion of cervical cancer cells, but enhanced cell apoptosis by cooperating with downregulated MELK expression. +exosome 33109253 hsa-mir-136 Cartilage Diseases 5p could promote chondrocyte migration in vitro and inhibit cartilage degeneration in vivo, thereby inhibiting OA pathology, which highlighted the transfer of exosomal miR +exosome 33109253 hsa-mir-136 Osteoarthritis 5p could promote chondrocyte migration in vitro and inhibit cartilage degeneration in vivo, thereby inhibiting OA pathology, which highlighted the transfer of exosomal miR +genetics_knock down_promote 33109222 hsa-mir-4677 Lung Neoplasms 3p or CDCA3 overexpression reversed circ_0001421 knockdown-mediated suppression on cell proliferation, migration, invasion and glycolysis in LC cells. +genetics_overexpression_promote 33109220 hsa-mir-195 Colonic Neoplasms Overexpression of MCM2 was shown to restore the stemness of colon cancer cells in the presence of miR +genetics_overexpression_promote 33109220 hsa-mir-497 Colonic Neoplasms Overexpression of MCM2 was shown to restore the stemness of colon cancer cells in the presence of miR +genetics_knock down_promote 33109127 hsa-mir-205 Uterine Cervical Neoplasms Knockdown of CHN1 obviously reduced the aggressive cellular behaviours induced by upregulation of miR-205, suggesting that miR-205 positively regulated CHN1 to mediate these cell behaviours during the development of cervical cancer. +transcription factor target 33109107 hsa-mir-203 Prostatic Neoplasms CONCLUSIONS: Our results show a novel link between miR-203 and IRS-1, and reveal the importance of strict control of IRS - 1 by miR-203 in the progression of PCa, suggesting miR-203 may act as a promising target for the diagnosis and treatment of advanced PCa. +lncRNA target 33108931 hsa-mir-149 Glaucoma 5p mimics mitigated the promoted impact on cell viability and the suppressive impact on apoptotic rate by targeting MALAT1.Conclusion: MALAT1 promoted cell proliferation and inhibited cell apoptosis of RGCs via targeting miR +circRNA target 33108919 hsa-mir-492 Retinoblastoma Furthermore, circTET1 suppressed tumor growth in xenograft models.Conclusion: CircTET1 inhibited RB progression by sponging miR-492/miR +circRNA target 33108919 hsa-mir-494 Retinoblastoma Furthermore, circTET1 suppressed tumor growth in xenograft models.Conclusion: CircTET1 inhibited RB progression by sponging miR-492/miR +lncRNA target 33108738 hsa-mir-145 Lung Neoplasms These findings indicate that linc00662 functions as an oncogene by acting as a competing endogenous RNA (ceRNA) and sponges and regulates miR5p in lung cancer, and thus may provide a potential target for treating lung cancer. +circulation_biomarker_diagnosis_ns 33108223 hsa-mir-21 Colorectal Neoplasms CONCLUSION: Our meta-analysis results suggest that circulating miR-21 has a potential diagnostic value with moderate sensitivity and good specificity for CRC. +other 33108067 hsa-mir-299 Osteosarcoma 3p, thus promoting MMP2 expression and activating the Wnt/beta-catenin signalling pathway. +transcription factor target 33108032 hsa-mir-195a Inflammatory Bowel Diseases In conclusion, Treg-Exo alleviated the DSS-induced IBD through transferring miR-195a-3p. +circulation_biomarker_diagnosis_ns 33107700 hsa-mir-1269a Carcinoma, Non-Small-Cell Lung 5p, and hsa-miR-1269a) were more abundant in serum exosomes from NSCLC patients. +exosome 33107695 hsa-mir-25 Hyperglycemia Our results indicated that M2 macrophage could improve HG-induced podocytes injury via secreting exosomal miR +other 33107691 hsa-let-7i Pancreatic Carcinoma Our results suggest that the KRAS/Lin28B axis drives the let-7i/TET3 pathway to maintain the stemness of pancreatic cancer cells. +genetics_overexpression_promote 33107676 hsa-mir-218 Squamous Cell Carcinoma of Head and Neck Taken together, our findings suggest that the overexpression of miR-218 may inhibit OSCC progression by inactivating the GREM1-dependent TGF-beta signalling pathway. +other 33107616 hsa-mir-34a Hepatitis B 5p, and miR-484 in AVH were upregulated. +other 33107616 hsa-mir-2278 Hepatitis B 3p in HBe negative compared to LR group. +other 33107616 hsa-mir-7-1 Hepatitis B 5p, and miR-484 in AVH were upregulated. +other 33107616 hsa-mir-613 Hepatitis B 3p in HBe negative compared to LR group. +other 33107616 hsa-mir-195 Hepatitis B 5p, and miR-484 in AVH were upregulated. +other 33107616 hsa-mir-940 Hepatitis B 5p, and miR-484 in AVH were upregulated. +other 33107616 hsa-mir-342 Hepatitis B 5p, and miR-484 in AVH were upregulated. +other 33107616 hsa-mir-503 Hepatitis B 3p in HBe negative compared to LR group. +other 33107616 hsa-mir-20a Hepatitis B 5p, and miR-484 in AVH were upregulated. +other 33107616 hsa-mir-221 Hepatitis B 5p, and miR-484 in AVH were upregulated. +other 33107616 hsa-mir-192 Hepatitis B 5p, and miR-484 in AVH were upregulated. +other 33107616 hsa-mir-3681 Hepatitis B 3p in HBe negative compared to LR group. +other 33107616 hsa-mir-615 Hepatitis B 3p in HBe negative compared to LR group. +other 33107616 hsa-mir-24 Hepatitis B 5p, and miR-484 in AVH were upregulated. +other 33107616 hsa-mir-152 Hepatitis B 3p in HBe negative compared to LR group. +other 33107616 hsa-mir-2 Hepatitis B 5p, and miR-484 in AVH were upregulated. +other 33107616 hsa-mir-130b Hepatitis B 5p, and miR-484 in AVH were upregulated. +other 33107616 hsa-mir-484 Hepatitis B 5p, and miR-484 in AVH were upregulated. +lncRNA target 33107401 hsa-mir-613 Glioma LINC00707 could offset the ability of miR-613 to inhibit glioma proliferation and invasion. +lncRNA target 33107391 hsa-mir-488 Thyroid Cancer, Papillary CONCLUSION: HOTAIR promoted the growth, migration, and invasion of papillary thyroid carcinoma mainly through regulating the miR5p/NUP205 axis. +exosome 33107350 hsa-mir-150 Osteoporosis 3p in exosomes. +circulation_biomarker_diagnosis_ns 33107309 hsa-mir-155 Neuromyelitis Optica The main objective is assessment of the potential of serum miR-23a, miR-155, and miR-572 to differentiate between MS and other neuroinflammatory diseases. +circulation_biomarker_diagnosis_ns 33107309 hsa-mir-23a Multiple Sclerosis The main objective is assessment of the potential of serum miR-23a, miR-155, and miR-572 to differentiate between MS and other neuroinflammatory diseases. +circulation_biomarker_diagnosis_ns 33107309 hsa-mir-23a Neuromyelitis Optica The main objective is assessment of the potential of serum miR-23a, miR-155, and miR-572 to differentiate between MS and other neuroinflammatory diseases. +circulation_biomarker_diagnosis_ns 33107309 hsa-mir-572 Multiple Sclerosis The main objective is assessment of the potential of serum miR-23a, miR-155, and miR-572 to differentiate between MS and other neuroinflammatory diseases. +circulation_biomarker_diagnosis_ns 33107309 hsa-mir-572 Neuromyelitis Optica The main objective is assessment of the potential of serum miR-23a, miR-155, and miR-572 to differentiate between MS and other neuroinflammatory diseases. +circulation_biomarker_diagnosis_ns 33107309 hsa-mir-155 Multiple Sclerosis The main objective is assessment of the potential of serum miR-23a, miR-155, and miR-572 to differentiate between MS and other neuroinflammatory diseases. +transcription factor target 33107061 hsa-mir-375 Diabetes Mellitus, Type 2 In addition, miR-375 may have the potential to be a new target in the treatment of Type 2 diabetes, and NAFPD due to its role in the adipogenesis of duct cells. +transcription factor target 33107061 hsa-mir-375 Cervical Rib Syndrome In addition, miR-375 may have the potential to be a new target in the treatment of Type 2 diabetes, and NAFPD due to its role in the adipogenesis of duct cells. +transcription factor target 33107061 hsa-mir-375 Hyperlipidemias The important findings can be summarized as follows: (i) adipogenesis and early stage beta-cell differentiation were stimulated in duct cells under lipotoxicity and glucolipotoxicity conditions, (ii) miR-375 expression was upregulated while its target Erk1 was downregulated and miR-375 inhibitor upregulated Erk1 while expression of adipogenesis markers was downregulated in duct cells under both conditions, (iii) apoptosis was induced in beta and duct cells under both conditions, (iv) lipotoxicity induced proliferation of co-cultured beta-cells. +lncRNA target 33106979 hsa-mir-27b Neurodegenerative Diseases Moreover, downregulating PVT1 suppressed the effects of upregulated PVT1 and downregulated miR-27b-3p induced by AD as well as media degeneration in vivo. +lncRNA target 33106979 hsa-mir-27b Alzheimer Disease In AD, PVT1 expression was upregulated, yet that of miR-27b-3p was downregulated. Moreover, downregulating PVT1 suppressed the effects of upregulated PVT1 and downregulated miR-27b-3p induced by AD as well as media degeneration in vivo. +genetics_knock down_suppress 33106914 hsa-mir-9 Carcinoma, Hepatocellular 5p knockdown on the proliferation, migration and invasion of HCC cells. +genetics_knock down_promote 33106913 hsa-mir-373 Glioma Collectively, MSC-AS1 knockdown suppressed cell growth and the chemoresistance of glioma cells to TMZ by regulating miR +other 33106209 hsa-mir-671 Adenocarcinoma of Lung Functional investigation further confirmed that the C8orf34-as1/miR5p/MFAP4 regulatory axis has important functions in LUAD cell migration and stemness. +tissue_expression_ns 33105660 hsa-mir-29c Urinary Bladder Neoplasms Finally, we evaluated the robustness of miR-29c-3p as normalizer in the expression study of miR-200c-3p, a potential diagnostic marker for BC. +lncRNA target 33105440 hsa-mir-15b Neuroblastoma In conclusion, SNHG16 downregulation suppressed neuroblastoma tumorigenicity by regulating cell cycle, proliferation, and metastasis via miR-15b-5p/PRPS1 axis. +transcription factor target 33105327 hsa-mir-188 Aortic Aneurysm, Abdominal These findings underscore the potential significance of miR5p in aneurysm pathogenesis and as a target for suppression of AAA disease. +circulation_biomarker_diagnosis_up 33104396 hsa-mir-184 Carcinoma, Non-Small-Cell Lung The AUC of serum miR-184 and miR-191 for the 3-year OS in patients with NSCLC was 0.869 and 0.879, respectively. +circulation_biomarker_diagnosis_up 33104396 hsa-mir-191 Carcinoma, Non-Small-Cell Lung The AUC of serum miR-184 and miR-191 for the 3-year OS in patients with NSCLC was 0.869 and 0.879, respectively. +other 33104023 hsa-mir-1292 Stomach Neoplasms 5p/DEK axis to modulate the malignant biological behaviors of GC. +lncRNA target 33104019 hsa-mir-129 Breast Neoplasms 5p/FZD7 axis, indicating that HOTAIR may be a potential biomarker and therapeutic target for breast cancer. +genetics_overexpression_promote 33103723 hsa-mir-371b Carcinoma, Non-Small-Cell Lung RESULTS: Our findings revealed that the miR-371b-5p was overexpressed in NSCLC and could markedly promote the cell proliferation, migration and invasion. +genetics_GWAS 33103535 hsa-mir-492 Hirschsprung Disease CONCLUSIONS: Our results suggest that the miR-492 rs2289030 G>C polymorphism is not associated with susceptibility to HSCR in southern Chinese children. +circulation_biomarker_diagnosis_ns 33103527 hsa-mir-145 Carcinoma, Non-Small-Cell Lung CONCLUSION: Serum miR-145 might be served as a potentially useful biomarker for NSCLC diagnosis. +lncRNA target 33103510 hsa-mir-513a Carcinoma, Non-Small-Cell Lung The present study showed that the relative LINC00473 expression was upregulated and miR-513a-3p expression was downregulated in radioresistant NSCLC patients compared with radiosensitive patients. LINC00473 inhibition enhances radiosensitivity of NSCLC by sponging miR-513a-3p, providing a promising therapeutic target to increase the sensitivity of radiotherapy in NSCLC patients. +transcription factor target 33103467 hsa-mir-202 Breast Neoplasms These findings suggest that TDZ suppresses breast cancer metastasis by targeting miRNA-132, the miR5p-PTEN axis, and the PI3K-Akt signaling pathway downstream. +other 33102604 hsa-mir-181a Diabetes Mellitus, Type 2 Our study suggested that miR-181a-5p possibly plays a key role in modulation of HDF behaviors during the diabetic state. +transcription factor target 33102581 hsa-mir-873 Glioma Conclusions miR5p can inhibit glioma cells to proliferate and invade, and promote their apoptosis, so it is expected to become a potential diagnostic index and therapeutic target for glioma. +lncRNA target 33102579 hsa-mir-495 Carcinoma, Hepatocellular Moreover, based on the bioinformatic analyses, our results found that LUCAT1 and ZFPM2-AS1 may affect the autophagic activity in HCC through the hsa-miR +other 33102573 hsa-mir-142 Nasopharyngeal Carcinoma Survival analysis indicated that ZNF667-AS1, LDHA, LMNB2, TPI1, UNG, and hsa-miR3p were significantly correlated with the prognosis of NPC. +other 33102210 hsa-mir-149 Carcinoma, Non-Small-Cell Lung Long Non-coding RNA HOTAIR Function as a Competing Endogenous RNA for miR-149-5p to Promote the Cell Growth, Migration, and Invasion in Non-small Cell Lung Cancer. +lncRNA target 33101593 hsa-mir-1 Acute Lung Injury 5p is a key pathogenic factor for inflammation and oxidative damage during LPS-induced ALI, which is related to Cab39-dependent inhibition of AMPKalpha. +target gene 33101465 hsa-mir-1225 Carcinoma, Non-Small-Cell Lung miR-1225-5p inhibits non-small cell lung cancer cell proliferation, migration and invasion, and may be a prognostic biomarker. +lncRNA target 33101368 hsa-mir-195 Prostatic Neoplasms Taken together, the key findings of our study demonstrated that lncRNA AGAP2-AS1 silencing exerted suppressive effects on the development of prostate cancer via the miR +other 33101221 hsa-mir-122 Hepatitis C The decreased miR-122 at 60 h was indirectly involved in lipid metabolism and is expected to attenuate rampant replication of HCV and potentially contribute to viral persistence. +circulation_biomarker_diagnosis_up 33101204 hsa-mir-1260a Polycystic Ovary Syndrome 5p, and miR let-7b-3p) differed between control and PCOS women that passed the false discovery rate (FDR) out of a total of 177 circulating miRNAs that were detected. +transcription factor target 33101013 hsa-mir-205 Triple Negative Breast Neoplasms These results revealed that CSO exerted an anti-TNBC effect via the miR-205/S1PR1 axis to regulate sphingomyelin metabolism, and the downstream STAT3/MAPK/AKT signal pathways were partly involved. +other 33100957 hsa-mir-3679 Moyamoya Disease 5p) as a biomarker for MMD diagnosis. +other 33100957 hsa-mir-6165 Moyamoya Disease 5p) as a biomarker for MMD diagnosis. +other 33100957 hsa-mir-6760 Moyamoya Disease 5p) as a biomarker for MMD diagnosis. +genetics_overexpression_promote 33100909 hsa-mir-7 Ovarian Neoplasms Overexpression of miR +genetics_overexpression_suppress 33100224 hsa-mir-137 Siderosis overexpressing EPC-EXs on apoptosis, mitochondrial dysfunction, and ferroptosis in oxyhemoglobin (oxyHb)-injured SH-SY5Y cells. +other 33100224 hsa-mir-137 Ischemic Stroke Additionally, miR-137 is reported to regulate ferroptosis and to be involved in the neuroprotection against ischemic stroke. +transcription factor target 33099960 hsa-mir-140 Wilms Tumor 5p can inhibit their proliferation and it may become a new target for the treatment of nephroblastoma in the future. +lncRNA target 33099957 hsa-mir-212 Osteosarcoma CONCLUSIONS: MiR-212 promotes the proliferation and inhibits the apoptosis of osteosarcoma cells by up-regulating the Hedgehog signaling pathway. +lncRNA target 33099955 hsa-mir-20a Melanoma CONCLUSIONS: Targeted binding of miR-320a to PBX3 protein can inhibit the malignant phenotype of cells and affects the occurrence and development of melanoma. +lncRNA target 33099953 hsa-mir-130b Glioma Silencing of miR-130b may inhibit the AKT signaling pathway through up-regulating PTEN, thereby suppressing the proliferation of glioma cells. +genetics_knock down_suppress 33099951 hsa-mir-151 Prostatic Neoplasms The results of western blot analysis showed that miR-151 overexpression blocks the Pi3K/AKT signalling pathway in prostate cancer cells. +genetics_knock down_promote 33099950 hsa-mir-505 Prostatic Neoplasms Knockdown of HMGB-1 inhibited cell invasion and migration and re-expression of HMGB-1 reversed miR-505 mimic inhibitory effect on PC cell invasion and migration. +genetics_overexpression_promote 33099949 hsa-mir-19a Prostatic Neoplasms RESULTS: The expression of miR-19a was high in prostate cancer and its overexpression predicted poor outcome of prostate cancer patients. +other 33099947 hsa-mir-182 Mouth Neoplasms miR-182 may be involved in the occurrence and deterioration of oral cancer and is a good indicator for predicting the treatment efficacy of patients with oral cancer. +lncRNA target 33099942 hsa-mir-122a Laryngeal Neoplasms CONCLUSION: Upregulation of miR-122a expression can reduce proliferation of laryngeal carcinoma cells and increase their apoptosis, and it can be used as a potential diagnostic index and therapeutic target for laryngeal carcinoma. +lncRNA target 33099935 hsa-mir-200a Uterine Cervical Neoplasms CONCLUSIONS: MiR-200a facilitates the proliferation of CC cells and activates the HIF-1alpha/VEGF signaling pathway by targeting EGLN1. +lncRNA target 33099931 hsa-mir-16 Liver Neoplasms These effects were also accompanied by inhibition of cell migration and invasion, indicating that miR-16 can have a significant role as liver cancer suppressor after zingiberene treatment. +genetics_knock down_promote 33099925 hsa-mir-1 Colonic Neoplasms The expression of PAX6 was found to be significantly upregulated in colon cancer cells and miR-31 overexpression suppressed its expression. +lncRNA target 33099915 hsa-mir-15a Breast Neoplasms PURPOSE: To explore the inhibition of proliferation and invasion of breast cancer cells by LncRNA SNHG7 via regulating the expression of miR-15a and its mechanism. SNHG7 can affect the proliferation and invasion of breast cancer cells through its targeted regulation of miR-15a activity. +circRNA target 33099906 hsa-mir-129 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: CircTHBS1 promotes the proliferation and inhibits the apoptosis of NSCLC cells through targeting miR +lncRNA target 33099847 hsa-mir-206 Influenza, Human Our results indicate that miR-206 has anti-influenza activity by targeting TNKS2 and subsequently activating the anti-viral state. +lncRNA target 33099720 hsa-mir-4784 Ovarian Neoplasms This study proved that ELK1 activated-LBX2-AS1 aggravated the progression of OC by targeting the miR-4784/KDM5C axis, suggesting that LBX2-AS2 may be a promising diagnostic biomarker of OC. +lncRNA target 33099584 hsa-mir-199a Carcinoma, Hepatocellular Thus, hepatic miR-199a-3p inhibits hepatocyte apoptosis and hepatocarcinogenesis, and decreased miR-199a-3p in hepatocytes may aggravate hepatic injury and HCC development. +lncRNA target 33099584 hsa-mir-199a-2 Carcinoma, Hepatocellular Thus, hepatic miR-199a-3p inhibits hepatocyte apoptosis and hepatocarcinogenesis, and decreased miR-199a-3p in hepatocytes may aggravate hepatic injury and HCC development. +lncRNA target 33099573 hsa-mir-488 Breast Neoplasms Therefore, the current finding predicted miR-488 as a tumor suppressor molecule in breast cancer, and demonstrated that Notch3/miR-488/FSCN1 axis is established and involved in regulating the metastasis of breast cancers, providing novel therapeutic targets for patients with breast cancers. +circulation_biomarker_diagnosis_ns 33098868 hsa-mir-34a Non-alcoholic Fatty Liver Disease The mechanisms by which miR-34a influences NAFLD through the Sirtuin 1 (SIRT1)-related pathway were investigated herein. HepG2 cells were transfected with a miR-34a mimic, inhibitor, SIRT1 small interfering RNA (siRNA), SIRT1 plasmid, and a negative oligonucleotide control to evaluate their role in oleic acid (OA) and excess iron-induced NAFLD. +genetics_overexpression_promote 33098639 hsa-mir-140 Urinary Bladder Neoplasms Overexpression of miR +genetics_overexpression_promote 33098307 hsa-mir-491 Retinoblastoma 3p were in Rb cells were almost entirely canceled out at the overexpression of SNN. +other 33098283 hsa-mir-203b Carcinoma, Hepatocellular 3p may significantly contribute to tumor pathogenesis in HCC and have potential to be used as a noninvasive biomarker for cancer therapy. +other 33098283 hsa-mir-33a Carcinoma, Hepatocellular 3p may significantly contribute to tumor pathogenesis in HCC and have potential to be used as a noninvasive biomarker for cancer therapy. +other 33098283 hsa-mir-361 Carcinoma, Hepatocellular 3p may significantly contribute to tumor pathogenesis in HCC and have potential to be used as a noninvasive biomarker for cancer therapy. +lncRNA target 33098266 hsa-mir-205 Pterygium In conclusion, FOXD2-AS1 is activated via its H3K27 acetylation and regulates VEGF-A expression by sponging miR +lncRNA target 33098220 hsa-mir-126 Neurodegenerative Diseases Next, through a series of functional experiments, we found that miR +exosome 33097483 hsa-mir-155 Diabetes Mellitus, Type 2 Furthermore, another CD31(+) EV-shuttled miRNA signature, i.e., miR-155, -320a, 3p, -376, and -422a, detected T2DM patients with a previous major adverse cardiovascular event. +exosome 33097483 hsa-mir-155 Cardiovascular Complications Furthermore, another CD31(+) EV-shuttled miRNA signature, i.e., miR-155, -320a, 3p, -376, and -422a, detected T2DM patients with a previous major adverse cardiovascular event. +other 33097010 hsa-mir-192 Osteosarcoma Circ_0000282/miR-192/XIAP axis regulated OSA cell proliferation apoptosis with competitive endogenous RNA mechanism. +transcription factor target 33095942 hsa-mir-874 Depression 3p may play an important role in preventing the LPS-induced depression-like behavior through inhibition of IDO1 expression. +other 33095908 hsa-mir-181a Cystic Fibrosis Compared with non-CF controls, several miRNAs were deregulated in CF samples; for instance, miR-181a-5p and the miR-449 family were upregulated. +other 33095897 hsa-mir-149 Coronary Artery Disease Furthermore, we demonstrated that miR3p expression is decreased in atherosclerotic coronary tissues. +other 33095833 hsa-mir-146a Community-Acquired Pneumonia 5p upon admission due to CAP are associated with lower mortality at 30 days of follow-up. +other 33095833 hsa-mir-16 Community-Acquired Pneumonia 5p upon admission due to CAP are associated with lower mortality at 30 days of follow-up. +lncRNA target 33095438 hsa-mir-106b Epilepsy, Temporal Lobe In sum, circ_ANKMY2 modulated TLE advancement via regulation of FOXP1 expression through sponging miR-106b-5p, and circ_ANKMY2 might be an underlying target for the improvement of TLE. +genetics_knock down_promote 33095185 hsa-mir-199a Polycystic Ovary Syndrome Gain- and loss-of-function experiments of miR-199a-5p were performed to determine its functions in PCOS. +lncRNA target 33094798 hsa-mir-495 Osteoarthritis TGFBR2 was targeted by miR-495 and lowly expressed in OA patients and IL-1beta-treated chondrocytes. +lncRNA target 33094608 hsa-mir-494 Liver Diseases, Alcoholic Therefore, the RBPE might exert protection against ALD by alleviating mitochondrial dysfunction and the resulting hepatocyte apoptosis via the PGC-1alpha-TFAM signal pathway mediated by microRNA3p. +genetics_overexpression_promote 33094104 hsa-mir-124 Carcinoma, Hepatocellular 3p deficiency is inversely co-related with CRKL overexpression in tumorous tissues of HCC patients, which was also consistent in HCCLM3 and Huh7 HCC cell lines. +exosome 33094092 hsa-mir-181a Leukemia In contrast, vincristine and prednisone could not induce apoptosis/pro-apoptotic genes in relapsed leukemia, and could not change the expression of cellular or exosomal miR-181a. +lncRNA target 33093919 hsa-mir-655 Squamous Cell Carcinoma of Head and Neck 3p directly targets FZD4 and negatively regulates its expression in OSCC. +lncRNA target 33093915 hsa-mir-421 Adenocarcinoma of Lung In conclusion, the results of the present study suggested that miR-421 may promote the viability of A549 lung cancer cells by targeting FOXO1 and modulating cell cycle, indicating that targeting miR-421 and FOXO1 may represent future therapeutic strategies for the treatment of patients with lung cancer. +genetics_overexpression_promote 33093914 hsa-mir-107 Colorectal Neoplasms In CRC cells, overexpression of UASR1 and miR-107 did not affect each other. +transcription factor target 33093897 hsa-mir-132 Alzheimer Disease In conclusion, miR-132 inhibited hippocampal iNOS expression and oxidative stress by inhibiting MAPK1expression to improve the cognitive function of rats with AD. +genetics_knock down_promote 33093892 hsa-mir-17 Osteoarthritis In conclusion, TUG1 knockdown inhibited OA progression by downregulating FUT1 via miR +target gene 33093810 hsa-mir-149 Colorectal Neoplasms Downregulation of long non-coding RNA MAFG-AS1 represses tumorigenesis of colorectal cancer cells through the microRNA-149-3p-dependent inhibition of HOXB8. +circulation_biomarker_diagnosis_ns 33093531 hsa-mir-149 Pre-Eclampsia Combined expression of miRs149 and 363 in the circulation at 36 weeks' gestation provides a test with 45% sensitivity (at a specificity of 90%) which suggests measuring both miRs may have promise as part of a multi-marker test to predict preeclampsia. +lncRNA target 33093529 hsa-mir-106b Prostatic Neoplasms We could validate RBMS1, a barely described RNA-binding protein, as a new target gene for oncogenic miR-106b, which was identified as an induced miRNA in PCa. +genetics_knock down_suppress 33093470 hsa-mir-22 Myotonic Disorders Celf1 knockdown partially reproduced miR-322/-503's function in rescuing DM1 C2C12 differentiation but was unable to repress ribonuclear foci, suggesting other targets of miR-322/-503 existed in the DM1 C2C12 cells. +genetics_knock down_suppress 33093470 hsa-mir-503 Myotonic Disorders Celf1 knockdown partially reproduced miR-322/-503's function in rescuing DM1 C2C12 differentiation but was unable to repress ribonuclear foci, suggesting other targets of miR-322/-503 existed in the DM1 C2C12 cells. +genetics_overexpression_suppress 33093452 hsa-mir-504 Glioma Overexpression of miR-504 exerted antitumor effects in GSCs as well as bystander effects on the polarization of microglia via delivery by EVs. +other 33093438 hsa-mir-373 Pre-Eclampsia NEAT1 was found to act as a molecular sponge for miR-373, regulating Fms-like tyrosine kinase-1 (FLT-1) to modulate PE development. +genetics_knock down_promote 33093283 hsa-mir-135a Pulmonary Veno-Occlusive Disease The exploration of the underlying mechanism demonstrated that knockdown of FOXO1 reversed PVT1/miR-135a-5p mediated hypoxia-induced injury in H9c2 cells. +genetics_overexpression_promote 33093239 hsa-mir-517a Vesicular Stomatitis In line with the antiviral activity of miR-517a, silencing UNC13D suppressed replication of vesicular stomatitis virus (VSV), whereas overexpression of UNC13D increased VSV levels, suggesting a role for UNC13D silencing in the antiviral activity of miR-517a. +genetics_overexpression_promote 33093239 hsa-mir-517a Sexually Transmitted Diseases, Viral In line with the antiviral activity of miR-517a, silencing UNC13D suppressed replication of vesicular stomatitis virus (VSV), whereas overexpression of UNC13D increased VSV levels, suggesting a role for UNC13D silencing in the antiviral activity of miR-517a. +other 33093236 hsa-mir-24 Obesity We found that HDL-associated miR-126, miR-222, and miR-223 levels, but not miR-24 levels, were significantly higher in patients with severe obesity when compared with healthy controls. +other 33093236 hsa-mir-126 Obesity We found that HDL-associated miR-126, miR-222, and miR-223 levels, but not miR-24 levels, were significantly higher in patients with severe obesity when compared with healthy controls. +other 33093236 hsa-mir-222 Obesity We found that HDL-associated miR-126, miR-222, and miR-223 levels, but not miR-24 levels, were significantly higher in patients with severe obesity when compared with healthy controls. +other 33093236 hsa-mir-223 Obesity We found that HDL-associated miR-126, miR-222, and miR-223 levels, but not miR-24 levels, were significantly higher in patients with severe obesity when compared with healthy controls. +genetics_overexpression_promote 33092644 hsa-mir-34a Ovarian Neoplasms Moreover, overexpression of miR-34a attenuated the effects of OIP5-AS1 overexpression on OC cell invasion and migration. +other 33092444 hsa-mir-34b Diabetic Cardiomyopathies In summary, our study demonstrates that GAS5 acts as a competing endogenous RNA to enhance AHR expression by sponging miR-34b-3p, which consequently represses NLRP3 inflammasome activation-mediated pyroptosis to improve DCM. +lncRNA target 33092435 hsa-mir-4465 Nasopharyngeal Carcinoma LncRNA GAS5 regulated nasopharyngeal carcinoma malignancy through targeting miR-4465 and modulating COX2. +genetics_knock down_promote 33092227 hsa-mir-23a Muscular Dystrophies Additionally, the knockdown of MDFIC by siRNA facilitated the MD of (PDGFRalpha-) bPCs, while the overexpression of MDFIC inhibited the activating effect of bta-miR-23a during MD. +other 33092191 hsa-mir-339 Post-Concussion Syndrome 5p may play a role in the pathophysiologic mechanism involved in cumulative concussion effects. +other 33092191 hsa-mir-28 Post-Concussion Syndrome 5p may play a role in the pathophysiologic mechanism involved in cumulative concussion effects. +other 33091366 hsa-mir-432 Heart Failure 5p was significantly decreased, and the focal adhesion, insulin, and PI3K/AKT pathways may play significant roles in PHF progression. +genetics_GWAS 33091189 hsa-let-7b Ovarian Neoplasms The loss of let-7b upregulates the expression of EZH2, which promotes ovarian cancer growth in vitro and in vivo. +genetics_knock down_promote 33090888 hsa-mir-613 Gallbladder Neoplasms Conclusion: UCA1 knockdown suppressed GBC progression through downregulating SPOCK1 via sponging miR-613, providing an evidence for UCA1 as a target for GBC treatment. +circRNA target 33090705 hsa-mir-1225 Squamous Cell Carcinoma of Head and Neck Our study provides strong evidence that circ_SEPT9/miR-1225/PKN2 axis is a promising target for OSCC treatment. +other 33090636 hsa-mir-152 Glioblastoma This study reveals SRC-1 promotes the stemness of GBM by activating the long noncoding RNA XIST/miR-152/KLF4 pathway and provides novel markers for diagnosis and therapy of GBM. +other 33090550 hsa-mir-143 Ovarian Neoplasms The negative feedback between miR-143 and DNMT3A regulates cisplatin resistance in ovarian cancer. +exosome 33090418 hsa-mir-338 Myocardial Infarction MicroRNA-338 in MSCs-derived exosomes inhibits cardiomyocyte apoptosis in myocardial infarction. +other 33090414 hsa-mir-181a Myocardial Infarction Next, H9c2 cells were transfected with miRNA-181a-5p mimic (MIM) or negative control (NC). +transcription factor target 33090414 hsa-mir-181a Myocarditis CONCLUSIONS: LPS stimulation can increase the expression of miR-181a-5p in BMSCs, and miR-181a-5p inhibits myocardial inflammation and oxidative stress by targeting ATF2. +genetics_overexpression_promote 33090407 hsa-mir-25 Thyroid Cancer, Papillary MiR-325 level was negatively correlated with PWRN2 level in PTC samples, and the overexpression of PWRN2 stimulated proliferative and migratory potentials in PTC cells, which were partially abolished by overexpression of miR-325. +lncRNA target 33090401 hsa-mir-203 Esophageal Squamous Cell Carcinoma It promotes migratory ability in esophageal cancer by targeting miR-203. +genetics_overexpression_promote 33090400 hsa-mir-18a Stomach Neoplasms RESULTS: ISH results of TMA showed that overexpression of miR-18a in GC tissues was significantly associated with low survival rate of patients (p<0.001). +other 33090399 hsa-mir-197 Stomach Neoplasms 3p. +other 33090398 hsa-mir-422a Colorectal Neoplasms Mechanistically, INHBA-AS1/miR-422a/AKT1 established the ceRNA network to regulate MMP-2, -7, -9 expressions that participated the modulation of CRC progression. +lncRNA target 33090397 hsa-mir-29 Carcinoma, Hepatocellular 3p inhibits hepatocellular carcinoma cell proliferation and migration through USP22-Wnt/-Catenin pathway. +genetics_overexpression_suppress 33090395 hsa-mir-4282 Pancreatic Carcinoma Overexpression of ABCB5 could abolish the inhibitory effects of overexpressed miR-4282 on the malignant progression of pancreatic cancer. +genetics_knock down_promote 33090394 hsa-mir-513a Urinary Bladder Neoplasms CONCLUSIONS: Our study illustrated that PCAT6 knockdown inhibited cell progression of BC by regulating miR-513a, suggesting that PCAT6 might act as a prognostic biomarker and therapeutic target for BC patients. +genetics_knock down_suppress 33090392 hsa-mir-193a Wilms Tumor At the same time, silencing microRNA-193a-5p reversed the reduced metastasis ability of WT cells induced by knockdown of XIST. +genetics_overexpression_suppress 33090391 hsa-mir-195 Prostatic Neoplasms After transfection of DU-145 and PC-3, it was found that silence of SNHG1 or overexpression of miR +lncRNA target 33090390 hsa-mir-155 Uterine Cervical Neoplasms Lnc-RNA UCA1 regulates EMT occurrence in cervical cancer cells by targeting miR-155. +lncRNA target 33090389 hsa-mir-200b Ovarian Neoplasms CONCLUSIONS: MiR-200b-5p can inhibit the proliferation and promote the apoptosis of OC cells through targeted inhibition of ATAD2 expression and regulation of the PI3K/Akt signaling pathway. +genetics_overexpression_promote 33090388 hsa-mir-619 Osteosarcoma Overexpression of miR-3619 inhibited OS progression, while this effect was abolished by the upregulation of LINC00665. CONCLUSIONS: We demonstrated that LINC 00665 accelerated OS development by targeting miR-3619. +genetics_overexpression_promote 33090337 hsa-mir-188 Squamous Cell Carcinoma of Head and Neck 5p; in addition, overexpression of MMP1 3'UTR up-regulated the expression level of SOX4 and CDK4, target genes of miR +genetics_knock down_promote 33090006 hsa-mir-503 Uterine Cervical Neoplasms 5p inhibitor could ameliorate the effects of circ_0085616 knockdown on CC cells. +lncRNA target 33089970 hsa-mir-376a Stomach Neoplasms Our results suggested that NUTM2A-AS1 promoted cell viability, invasion, and drug resistance of gastric cancer cells, which was largely rescued by miR-376a. +genetics_knock down_suppress 33089961 hsa-mir-135b Femur Head Necrosis During the treatment of ONFH, the administration of hiPS-MSC-Exos and miR-135b alleviated the magnitude of bone loss. +genetics_overexpression_promote 33089952 hsa-mir-342 Adenocarcinoma of Lung RESULTS: SNHG20 and DDX49 were overexpressed, while miR-342 was lowly expressed in lung adenocarcinoma tissues and cell lines. +circRNA target 33089764 hsa-mir-495 Glioma 3p, thus accelerating glioma progression through CXCR2 axis. +transcription factor target 33089633 hsa-mir-128 Fever OBJECTIVES: This study aimed to verify whether the target gene of miR +other 33089034 hsa-mir-29 Acquired Immunodeficiency Syndrome Interestingly, several transcripts involved in HIV-restriction were upregulated (Caveolin-1, TRIM22, TRIM5alpha, BST2, miR-29), whereas HIV permissiveness transcripts were downregulated (CCR5, furin), consistent with the decrease in HIV outgrowth/replication. +genetics_knock down_promote 33088424 hsa-mir-210 Sarcoma, Ewing Inhibition of miR-210 in hypoxic spheres attenuated sphere formation and overexpression of miR-210 in normoxic spheres significantly enhanced the number of EWS spheres. +lncRNA target 33088221 hsa-mir-34a Prostatic Neoplasms Moreover, DAAM1 was targeted by miR-34a-5p and promoted PCa progression. +lncRNA target 33088220 hsa-mir-204 Carcinoma, Renal Cell 5p might be indicated in RCC progression via RUNX2, suggesting the potential use of SNHG4/miR +target gene 33088216 hsa-mir-5590 Triple Negative Breast Neoplasms Long non-coding RNA MIR100HG promotes the migration, invasion and proliferation of triple-negative breast cancer cells by targeting the miR-5590-3p/OTX1 axis. +genetics_overexpression_promote 33088215 hsa-mir-27a Stomach Neoplasms Functional experiments also showed that, miR-27a-3p overexpression boosted the malignant biological behaviors of GC cells; on the contrast, these phenotypes were impeded by miR-27a-3p inhibition. +circulation_biomarker_diagnosis_ns 33087810 hsa-mir-21 Leukemia Additionally, case studies were implemented with leukemia, breast neoplasms and hsa-mir-21. +circulation_biomarker_diagnosis_ns 33087810 hsa-mir-21 Breast Neoplasms Additionally, case studies were implemented with leukemia, breast neoplasms and hsa-mir-21. +transcription factor target 33087705 hsa-mir-181c Glioma Taken together, our data revealed a new miR-181c/RPN2/wnt/beta-catenin signaling axis that plays significant roles in glioma tumorigenesis and TMZ resistance, and it represents a potential therapeutic target, especially in GBM. +lncRNA target 33087165 hsa-mir-495 Prostatic Neoplasms Furthermore, KDM5A was found to downregulate MOB3B expression, consequently augmenting PCa cell proliferation, migration and invasion in vitro and promoting tumor growth in vivo via the miR-495/YTHDF2 axis. +genetics_knock down_promote 33087088 hsa-mir-451a Urinary Bladder Neoplasms Subsequently, we detected miR-451a expression and CpG island methylation of the promoter in BCa cells T24 and 5637 with DNMT3B knockdown. +circulation_biomarker_prognosis_ns 33086901 hsa-mir-206 Familial Primary Pulmonary Hypertension CONCLUSION: Current model combining plasma microRNA-206, IL-4, IL-13, and INF-gamma has potential significance for prognosis of asthma induced PAH. +circulation_biomarker_diagnosis_up 33086588 hsa-mir-199b Lymphoma, Non-Hodgkin A comparative analysis of miRNA expression levels between the NHL and non-cancer blood disorders samples revealed that let-7a-5p was upregulated, and miR-26a-5p, miR-199b-5p, miR +circulation_biomarker_diagnosis_up 33086588 hsa-mir-145 Myelodysplastic Syndromes A comparative analysis of miRNA expression levels between the NHL and non-cancer blood disorders samples revealed that let-7a-5p was upregulated, and miR-26a-5p, miR-199b-5p, miR +circulation_biomarker_diagnosis_up 33086588 hsa-mir-199b Myelodysplastic Syndromes A comparative analysis of miRNA expression levels between the NHL and non-cancer blood disorders samples revealed that let-7a-5p was upregulated, and miR-26a-5p, miR-199b-5p, miR +circulation_biomarker_diagnosis_up 33086588 hsa-let-7a Lymphoma, Non-Hodgkin A comparative analysis of miRNA expression levels between the NHL and non-cancer blood disorders samples revealed that let-7a-5p was upregulated, and miR-26a-5p, miR-199b-5p, miR +circulation_biomarker_diagnosis_up 33086588 hsa-let-7a Myelodysplastic Syndromes A comparative analysis of miRNA expression levels between the NHL and non-cancer blood disorders samples revealed that let-7a-5p was upregulated, and miR-26a-5p, miR-199b-5p, miR +circulation_biomarker_diagnosis_up 33086588 hsa-mir-145 Lymphoma, Non-Hodgkin A comparative analysis of miRNA expression levels between the NHL and non-cancer blood disorders samples revealed that let-7a-5p was upregulated, and miR-26a-5p, miR-199b-5p, miR +lncRNA target 33086498 hsa-mir-650 Breast Neoplasms No target gene has been described for miR-650 in BRCA, thus, this bioinformatic study provides valuable information that should be corroborated experimentally. +genetics_overexpression_suppress 33086148 hsa-mir-381 Uterine Cervical Neoplasms The Overexpression of miRNA-381 further inhibited the migration and invasion of cervical cancer cells. +lncRNA target 33085926 hsa-mir-488 Colorectal Neoplasms "3p/IGF1R"" pathway was involved in the development of CRC, which may be the target for developing therapeutic approaches for CRC." +lncRNA target 33085838 hsa-mir-637 Glioma Functionally, silencing circEPHB4 or increasing miR-637 levels in glioma cells was sufficient to inhibit xenograft growth in vivo. +lncRNA target 33085761 hsa-mir-670 Carcinoma, Non-Small-Cell Lung 5p/RBM24 axis, and it may have the potential to be a biomarker or therapeutic target for NSCLC. +lncRNA target 33085760 hsa-mir-1827 Adenocarcinoma of Lung Our data identified a novel signaling axis of miR-1827/CAV-1 in regulating anoikis resistance, which might serve as a potential therapeutic target for metastatic NSCLC. +transcription factor target 33085741 hsa-mir-150 Metabolic Diseases Collectively, miR-150 reduced glucose utilization by directly decreasing the expression and translocation of GLUT4 in the cardiomyocytes with IR and therefore might be a new therapeutic target for metabolic diseases such as T2DM. +transcription factor target 33085741 hsa-mir-150 Diabetes Mellitus, Type 2 We found here that miR-150 level was elevated in myocardium of type 2 diabetes mellitus (T2DM) rat model and in insulin-resistant cardiomyocytes induced by high glucose (25 mM) and high insulin (1 muM). Collectively, miR-150 reduced glucose utilization by directly decreasing the expression and translocation of GLUT4 in the cardiomyocytes with IR and therefore might be a new therapeutic target for metabolic diseases such as T2DM. +lncRNA target 33085646 hsa-mir-23a Glioma In conclusion, lncRNA DGCR5 suppresses the capacity of glioma cells to migrate and invade via miR-21/Smad7, whereas it inhibits the proliferation and enhances the apoptosis of glioma cells through miR-23a/PTEN. +lncRNA target 33085646 hsa-mir-21 Glioma In conclusion, lncRNA DGCR5 suppresses the capacity of glioma cells to migrate and invade via miR-21/Smad7, whereas it inhibits the proliferation and enhances the apoptosis of glioma cells through miR-23a/PTEN. +genetics_GWAS 33085641 hsa-mir-146a Mesothelioma, Malignant Subjects and methods In total, 394 patients with pleural plaques, 277 patients with MM, and 175 healthy control subjects were genotyped for IL1B and MIR146A polymorphisms. +other 33085241 hsa-mir-148a Squamous Cell Carcinoma of Head and Neck The high expression of lncRNA PCGEM1 may enhance the TGF beta2/Smad2 signaling pathway by upregulating miR-148a, thus promoting the development of OSCC. +circRNA target 33084863 hsa-mir-145 Carcinoma, Non-Small-Cell Lung hsa_circ_0102231 promotes NSCLC cell proliferation and invasion by sponge for miR-145. Our findings suggest that hsa_circ_0102231 promotes proliferation and invasion by mediating the miR-145/RBBP4 axis in NSCLC, indicating that it might be a potential target for NSCLC treatment. +lncRNA target 33084599 hsa-mir-129 Reperfusion Injury We showed that exogenous miR5p restored cardiac function indices, alleviated cardiac injury, relieved inflammatory effects and reduced infarct size and cell apoptosis in rat myocardium after I/R treatment. +lncRNA target 33084522 hsa-mir-377 Colonic Neoplasms In conclusion, miR-377 regulates cancer stem cell phenotypes and EMT in colon cancer cells via regulation of ZEB2, suggesting a new therapeutic strategy for colon cancer treatment. +genetics_knock down_promote 33084415 hsa-mir-223 Arthritis, Rheumatoid 3p knockdown RA-FLS cells. +other 33084403 hsa-mir-146b Atherosclerosis Aim: To explore the potentially important role of miRNA 146b-5p (miR-146b) during the development of atherosclerosis. Conclusion: miR-146b is a novel regulator of vascular smooth muscle cell function induced by inflammatory response, specifically in neointima formation, and offers a novel therapeutic strategy for treating atherosclerosis. +circRNA target 33083473 hsa-mir-1224 Leukemia, Myeloid, Acute Conclusion CircRNF13 inhibited the proliferation, migration, and invasion of AML cells by regulating the expression of miRNA +circulation_biomarker_diagnosis_up 33083454 hsa-mir-766 high grade glioma 5p and miR-376b-5p in serum exosomes might be used as auxiliary diagnostic indicators for high-grade glioma and intracranial lymphoma, and miR +lncRNA target 33083296 hsa-mir-215 Retinoblastoma HXO-Rb44 and Y79 cell lines were transfected with miR-215 analogs or miR-215 inhibitors, and the expression of Rb1 protein in the cell lines was detected by western blotting. +lncRNA target 33083112 hsa-mir-130a Breast Neoplasms In addition, some transcription factors and miRNAs (e.g., E2F1, PTTG1, TP53, ZBTB16, hsa-miR-130a-3p, hsa-miR5p) targeting hub genes were identified as key regulators in the progression of breast cancer. +lncRNA target 33083112 hsa-mir-204 Breast Neoplasms In addition, some transcription factors and miRNAs (e.g., E2F1, PTTG1, TP53, ZBTB16, hsa-miR-130a-3p, hsa-miR5p) targeting hub genes were identified as key regulators in the progression of breast cancer. +target gene 33083023 hsa-mir-370 Breast Neoplasms Long noncoding RNA FGF14-AS2 inhibits breast cancer metastasis by regulating the miR-370-3p/FGF14 axis. +lncRNA target 33082912 hsa-mir-98 Brain Ischemia CONCLUSION: Our finding indicated that RiPerC inhibited the MCAO-induced expression of PIK3IP1 through upregulated miR-98, thereby reducing the apoptosis induced by PIK3IP1 through the PI3K/AKT signaling pathway, thus reducing the cerebral ischemia-reperfusion injury. +lncRNA target 33082860 hsa-mir-155 Atherosclerosis In conclusion, miR-155 induces EC apoptosis and inflammatory response, weakens aortic diastolic function, and promotes the progression of atherosclerosis through targeted inhibition of Bmal1. +exosome 33082517 hsa-mir-21 Retinal Degeneration These findings uncovered the efficacy and mechanism of MSCT-based photoreceptor protection, indicating exosomal miR-21 as a therapeutic for retinal degeneration. +other 33082482 hsa-mir-221 Glioblastoma miR-221 was up-regulated in our resistant cell lines, and this up-regulation led to a significant reduction in EGFR expression in both our cultured cell lines and a large cohort of glioblastoma patient tumor tissue. +lncRNA target 33082306 hsa-mir-372 Adenocarcinoma of Lung Our data describe that KCNQ1OT1 is responsible for SBRT resistance in LUAD through induction of ATG5- and ATG12-dependent autophagy via sponging miR3p, which would be a potential strategy to enhance the antitumor effects of radiotherapy in LUAD. +genetics_overexpression_promote 33082297 hsa-mir-508 Nasopharyngeal Carcinoma In addition, rescue assays showed that FN1 overexpression (or miR +other 33081933 hsa-mir-155 Breast Neoplasms Recent studies have indicated higher expression of miRNA-155 (miR-155) in patients with breast cancer compared to healthy people. In the present report, a rapid and sensitive electrochemical biosensor has been developed for detection of miR-155 as a breast cancer risk factor. +lncRNA target 33081707 hsa-mir-1297 Peri-Implantitis Through the mutual verification of the two datasets, we found that GSK3B and miR-1297 may have important significance in the immune microenvironment and pathogenesis of peri-implantitis and GSK3B was closely related to four types of immune cells, especially with the highest correlation with resting mast cells (P = 0.0003). +lncRNA target 33081480 hsa-mir-155 Neurogenic Inflammation Additionally, GLGZD was able to inhibit miR-155 upregulation, resulting in down-regulation of miR155-targeted molecules in MCAO rats, including suppressor of cytokine signaling 1 (SOCS1), inhibitor of nuclear factor kappa-B kinase (IKK), mothers against decapentaplegic homolog 2 (SMAD2) and CCAAT/ enhancer binding protein beta (CEBPbeta). +lncRNA target 33081480 hsa-mir-155 Ischemic Stroke Additionally, GLGZD was able to inhibit miR-155 upregulation, resulting in down-regulation of miR155-targeted molecules in MCAO rats, including suppressor of cytokine signaling 1 (SOCS1), inhibitor of nuclear factor kappa-B kinase (IKK), mothers against decapentaplegic homolog 2 (SMAD2) and CCAAT/ enhancer binding protein beta (CEBPbeta). +other 33081077 hsa-mir-23b Carcinoma, Ovarian Epithelial Metformin decreased the NGF-induced transcriptional activity of MYC and β-catenin/T-cell factor/lymphoid enhancer-binding factor (TCF-Lef), as well as the expression of c-MYC, survivin and VEGF in EOC cells, while it increased miR-23b and miR-145 levels. +other 33081077 hsa-mir-145 Carcinoma, Ovarian Epithelial Metformin decreased the NGF-induced transcriptional activity of MYC and β-catenin/T-cell factor/lymphoid enhancer-binding factor (TCF-Lef), as well as the expression of c-MYC, survivin and VEGF in EOC cells, while it increased miR-23b and miR-145 levels. +genetics_knock down_suppress 33080572 hsa-mir-203a Stomach Neoplasms A knockdown assay confirmed that the DLGAP1-AS1/miR-203a-3p/THBS2 axis is a ceRNA network involved in GC progression. In this study, we elucidated the role of the DLGAP1-AS1/miR-203a-3p/THBS2 ceRNA network in the progression of GC. +genetics_knock down_promote 33080570 hsa-mir-129 Glioma 5p overexpression or ZRANB2 knockdown reduces proliferation and colony formation of FAM181A-AS1 overexpressing glioma cells. +other 33080340 hsa-mir-122 Hepatitis The HNF4alpha/miR-122/CCL2 pathway, identified by our previous studies to induce macrophages infiltration, is initiated by chronic mild HIO. In conclusion, these results elucidate an oxidative-stress-independent, TRIP12/YY1/HNF4alpha/miR-122/CCL2 pathway of chronic mild HIO inducing hepatic inflammation, implying that effective measures in addition to antioxidants are needed for individuals at the risk of chronic mild HIO. +lncRNA target 33080315 hsa-mir-193b Osteoarthritis Collectively, these researches indicate that miR-193b/ST3GAL4 axis impacts OA progression by regulating CD44 sialylation via NF-small ka, CyrillicB pathway. +transcription factor target 33080309 hsa-mir-15b Carcinoma, Hepatocellular Elevated levels of miR-15b were transferred from arsenite-treated-THP-1 (As-THP-1) cells to HCC cells via miR-15b in EVs inhibited activation of the Hippo pathway by targeting LATS1, and was involved in promoting the proliferation, migration, and invasion of HCC cells. In conclusion, miR-15b in EVs from As-THP-1 cells is transferred to HCC cells, in which it targets and downregulates LATS1 expression and promotes the proliferation, migration, and invasion of HCC cells. +circulation_biomarker_prognosis_up 33079781 hsa-mir-223 Colorectal Neoplasms The association between serum miRNA-223 expression and CRC development was validated in the second set and the ROC curve showed highly significant prognostic value with 90.1% sensitivity, 87% specificity, and area under the curve of 0.914 (95% confidence interval: 0.830-0.978, P = 0.0001). +other 33079387 hsa-let-7b Arthritis, Psoriatic miR-Let7b administration exacerbated suboptimal joint inflammation along with metabolic reconfiguration of the PsA-like preclinical model. +lncRNA target 33079387 hsa-mir-29 Arthritis, Psoriatic We found that endogenous TLR7 ligands, miR-29 and miR-Let7b, were markedly increased in PsA compared to osteoarthritis (OA) synovial fluid (SF)s. +other 33078836 hsa-mir-34a Chemical and Drug Induced Liver Injury In conclusion, we identified miR-34a-5p, miR3p, and miR-15b-3p as translational biomarker candidates for early detection of KCZ-induced liver injury with a workflow applicable to computational toxicology studies. +other 33078836 hsa-mir-31 Chemical and Drug Induced Liver Injury In conclusion, we identified miR-34a-5p, miR3p, and miR-15b-3p as translational biomarker candidates for early detection of KCZ-induced liver injury with a workflow applicable to computational toxicology studies. +other 33078836 hsa-mir-15b Chemical and Drug Induced Liver Injury In conclusion, we identified miR-34a-5p, miR3p, and miR-15b-3p as translational biomarker candidates for early detection of KCZ-induced liver injury with a workflow applicable to computational toxicology studies. +genetics_knock down_promote 33078826 hsa-mir-183 Carcinoma, Hepatocellular 5p knockdown on malignant phenotypes of HCC cells. +lncRNA target 33078654 hsa-mir-214 Hepatitis, Non-Alcoholic Thus, Mir214-3p is a potential therapeutic target for nonalcoholic fatty disease.Abbreviations: AMPK: adenosine monophosphate-activated protein kinase; ATG: autophagy-related; ChIP: chromatin immunoprecipitation; CTSB: cathepsin B; CTSL: cathepsin L; CQ: chloroquine; HFD: high-fat diet; HNF4A: hepatocyte nuclear factor 4, alpha; IF: immunofluorescence; IHC: immunohistochemistry; LDs: lipid droplets; Leup: leupeptin; LFD: low-fat diet; LNA: locked nucleic acid; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; miRNA: microRNA; MTOR: mechanistic target of rapamycin kinase; NAFLD: non-alcoholic fatty liver disease; NASH: non-alcoholic steatohepatitis; PCR: polymerase chain reaction; TEM: transmission electron microscopy; TF: transcription factor; TLDA: TaqMan low-density array; ULK1: unc-51 like kinase 1; UTR: untranslated region. +lncRNA target 33078418 hsa-mir-125b Burns Our previous study confirmed the critical role of miR-125b and vascular endothelial growth factor (VEGF) in burn wound repair., The present study was aimed to identify the role of long noncoding RNAs (lncRNAs) related to the function of miR-125b and VEGF in burn wound repair and the underlying mechanism. In conclusion, PDK1-AS relieves miR-125b-5p-induced inhibition on VEGFA by acting as a endogenous RNA, therefore modulating HDMEC and HUVEC angiogenesis after thermal injury. +other 33078370 hsa-mir-124 Glioma In summary, our study depicts a novel pathway of MALAT1/miR-124/ZEB2 that regulates the progression of glioma and might provide a promising strategy for glioma therapy. +other 33078195 hsa-mir-96 Osteosarcoma We found that MiRNA-122 and miRNA-96 were widely up-regulated in osteosarcoma, gastric cancer and pancreatic cancer. +other 33078195 hsa-mir-122 Osteosarcoma We found that MiRNA-122 and miRNA-96 were widely up-regulated in osteosarcoma, gastric cancer and pancreatic cancer. +lncRNA target 33077816 hsa-mir-223 Sepsis We investigated the role of miR-223 in cell proliferation and apoptosis to identify potential target downstream proteins in sepsis. We conclude that miR-223 can serve as a protective factor in sepsis by reducing apoptosis and enhancing cell proliferation in lymphocytes by interacting with FOXO1. +genetics_knock down_promote 33077697 hsa-mir-143 Leukemia, Myeloid, Acute By contrast, miR-143 knockdown inhibits cytarabine-induced cytotoxicity, together indicating a role of miR-143 in enhancing cytarabine sensitivity in AML. +genetics_overexpression_suppress 33077486 hsa-mir-363 Thyroid Cancer, Papillary We found that overexpression miR +genetics_overexpression_suppress 33077307 hsa-mir-125a Head and Neck Neoplasms RESULTS: In this study, overexpression of miR-125a-5p significantly inhibited the proliferation of head and neck cancer cells, whereas inhibition of miR-125a-5p enhanced their proliferation. +genetics_overexpression_promote 33076979 hsa-mir-214 Hyalinosis, Systemic Conversely, overexpression of miR +genetics_GWAS 33076962 hsa-mir-342 Lymphoma, B-Cell Epigenetic silencing of miR +lncRNA target 33076502 hsa-mir-29b Alzheimer Disease Accordingly, this study aims to develop nanocarriers for targeted delivery of recombinant precursor microRNA (pre-miR-29b), foreseeing a decrease in the expression of the BACE1 protein, with potential implications in Alzheimer's disease (AD) treatment. +other 33076374 hsa-mir-164e Dehydration miR156k and miR164e were upregulated by drought in teosinte but downregulated in maize. +other 33076374 hsa-mir-156 Dehydration miR156k and miR164e were upregulated by drought in teosinte but downregulated in maize. +circulation_biomarker_diagnosis_ns 33076256 hsa-mir-451a Ischemic Stroke We evaluated the expression of serum miRNA5p and -451a in diabetic patients with ischemic stroke and correlated them with two markers of brain tissue integrity. +circulation_biomarker_diagnosis_ns 33076256 hsa-mir-451a Diabetes Mellitus, Type 2 We evaluated the expression of serum miRNA5p and -451a in diabetic patients with ischemic stroke and correlated them with two markers of brain tissue integrity. +circulation_biomarker_diagnosis_ns 33076256 hsa-mir-195 Ischemic Stroke We evaluated the expression of serum miRNA5p and -451a in diabetic patients with ischemic stroke and correlated them with two markers of brain tissue integrity. +circulation_biomarker_diagnosis_ns 33076256 hsa-mir-195 Diabetes Mellitus, Type 2 We evaluated the expression of serum miRNA5p and -451a in diabetic patients with ischemic stroke and correlated them with two markers of brain tissue integrity. +other 33075494 hsa-mir-221 Metabolic Diseases 3p) is associated with both metabolic diseases and cancers. +other 33075494 hsa-mir-221 Familial Multiple Coagulation Factor Deficiency I 3p expression in tumor-proximal adipose biopsies from BC patients analyzed. +other 33075494 hsa-mir-221 Breast Neoplasms 3p expression in tumor-proximal adipose biopsies from BC patients analyzed. +other 33075457 hsa-mir-650 Reperfusion Injury, Cerebral Ischemia In conclusion, we verified a TALNEC2/miR-650/APAF1 signaling pathway as a key mechanism monitoring cerebral I/R injury. +epigenetics 33075314 hsa-mir-126 FG syndrome 5p levels in FGR were associated with increased hg-miR-21 gene promoter methylation, with no changes in hg-miR-126 gene promoter methylation. +epigenetics 33075314 hsa-mir-21 FG syndrome 5p levels in FGR were associated with increased hg-miR-21 gene promoter methylation, with no changes in hg-miR-126 gene promoter methylation. +exosome 33075119 hsa-mir-590 Mucositis CONCLUSION: M2 macrophage-derived exosomal miR3p reduces inflammatory signals and promotes epithelial regeneration by targeting LATS1 and subsequently activating YAP/beta-catenin-regulated transcription, which could offer a new opportunity for clinical therapy for ulcerative colitis. +transcription factor target 33074595 hsa-mir-133a Lung Neoplasms BACKGROUND: MiR-133a has been confirmed to be involved in the development of multiple cancers including non-small cell lung cancer (NSCLC). CONCLUSIONS: In conclusion, miR-133a acted as a tumor suppressor in lung cancer progression by regulating the LASP1 and TGF-beta/Smad3 signaling pathway. +genetics_knock down_promote 33074219 hsa-mir-128 Angelman Syndrome CONCLUSION: GAS5 knockdown promoted the growth of ox-LDL-induced THP-1 cells through down-modulating FBLN2 and increasing miR +other 33074217 hsa-mir-34a Stomach Neoplasms In contrast, a negative correlation between lncRNA-SNHG7 and miR-34a was found that miR-34a was downregulated in gastric cancer patient tissues and significantly sensitized cisplatin resistant gastric cancer cells. Intriguingly, bioinformatical analysis indicated miR-34a has putative biding site for SNHG7 and such negative association between SNHG7 and miR-34a was verified in gastric cancer tissues. +circulation_biomarker_prognosis_down 33073957 hsa-mir-429 Osteosarcoma 3p expression (0.7463 0.0282) were significantly down-regulated in the serum from OS patients. +circulation_biomarker_prognosis_down 33073957 hsa-mir-143 Osteosarcoma 3p expression (0.7463 0.0282) were significantly down-regulated in the serum from OS patients. +circulation_biomarker_diagnosis_up 33073947 hsa-mir-133 Cerebral Infarction, Acute The correlation analysis showed that serum miR-133 was positively correlated with IL-6, IL-8, CRP, and TNF-alpha in ACI patients. +circulation_biomarker_diagnosis_up 33073943 hsa-mir-2467 Diabetes, Gestational CONCLUSIONS: Altogether, the high level of serum miR-2467 can be used for the preliminary screening of GDM. +lncRNA target 33073888 hsa-mir-30 Colorectal Neoplasms Therefore, the SH3PXD2A-AS1/miR5p/UBA2 network could regulate the progression of CRC through the Wnt/beta-catenin pathway. +genetics_overexpression_promote 33073840 hsa-mir-1183 Rheumatic Heart Disease Overexpression of miR-1183 in RHD patients and cell lines down-regulated BCL-2 expression and induced apoptosis. +lncRNA target 33073716 hsa-mir-1246 COVID-19 Moreover, the miRNA prediction analysis revealed that miR-1246, whose upregulation has been experimentally established to be a cause of acute respiratory distress syndrome (ARDS), was found to be targeting the coding DNA sequence (CDS) of ACE2. +lncRNA target 33073700 hsa-mir-425 Leukemia, Myeloid, Acute The aim of the investigation was to probe the regulatory relevance of long non-coding RNA (lncRNA) aspartyl-tRNA synthetase anti-sense 1 (DARS-AS1)/microRNA-425 (miR-425)/transforming growth factor-beta 1 (TGFB1) to the development of AML. CONCLUSION: All in all, we highlighted here that DARS-AS1 enhanced the expression of TGFB1 through binding to miR-425 to modulate AML progression via the Smad2/3 pathway, which might perform as a therapeutic target for AML. +lncRNA target 33073697 hsa-mir-124 Carcinoma, Hepatocellular 3p-cyclin D1/CDK6 pathway may be a novel potential therapeutic target for HCC treatment. +lncRNA target 33073681 hsa-mir-613 Pancreatic Carcinoma Through further mechanistic investigation, we demonstrate that miR +lncRNA target 33073675 hsa-mir-2116 Colorectal Neoplasms CONCLUSION: Our study revealed that FALEC promoted CRC progression via restoring the expression of miR +other 33072784 hsa-mir-122 Shock, Hemorrhagic The data showed a very strong correlation between liver injury and miR5p (r = 0.91, p < 0.00001). +lncRNA target 33072745 hsa-mir-7 Stomach Neoplasms Our results thus provide novel evidence that miR-7 is a key mediator of GC growth and chemosensitivity through its regulation of LDH-A, thus potentially highlighting this pathway as a therapeutic target for treating affected patients. +circulation_biomarker_diagnosis_ns 33072549 hsa-mir-29 Pancreatic Carcinoma Early-Onset Diabetes as Risk Factor for Pancreatic Cancer: miRNA Expression Profiling in Plasma Uncovers a Role for miR-20b-5p, miR-29a, and miR-18a-5p in Diabetes of Recent Diagnosis. +circulation_biomarker_diagnosis_ns 33072549 hsa-mir-18a Pancreatic Carcinoma Early-Onset Diabetes as Risk Factor for Pancreatic Cancer: miRNA Expression Profiling in Plasma Uncovers a Role for miR-20b-5p, miR-29a, and miR-18a-5p in Diabetes of Recent Diagnosis. +circulation_biomarker_diagnosis_ns 33072549 hsa-mir-20b Diabetes Mellitus Early-Onset Diabetes as Risk Factor for Pancreatic Cancer: miRNA Expression Profiling in Plasma Uncovers a Role for miR-20b-5p, miR-29a, and miR-18a-5p in Diabetes of Recent Diagnosis. +circulation_biomarker_diagnosis_ns 33072549 hsa-mir-20b Pancreatic Carcinoma Early-Onset Diabetes as Risk Factor for Pancreatic Cancer: miRNA Expression Profiling in Plasma Uncovers a Role for miR-20b-5p, miR-29a, and miR-18a-5p in Diabetes of Recent Diagnosis. +circulation_biomarker_diagnosis_ns 33072549 hsa-mir-29a Diabetes Mellitus Early-Onset Diabetes as Risk Factor for Pancreatic Cancer: miRNA Expression Profiling in Plasma Uncovers a Role for miR-20b-5p, miR-29a, and miR-18a-5p in Diabetes of Recent Diagnosis. +circulation_biomarker_diagnosis_ns 33072549 hsa-mir-29a Pancreatic Carcinoma Early-Onset Diabetes as Risk Factor for Pancreatic Cancer: miRNA Expression Profiling in Plasma Uncovers a Role for miR-20b-5p, miR-29a, and miR-18a-5p in Diabetes of Recent Diagnosis. +circulation_biomarker_diagnosis_ns 33072549 hsa-mir-18a Diabetes Mellitus Early-Onset Diabetes as Risk Factor for Pancreatic Cancer: miRNA Expression Profiling in Plasma Uncovers a Role for miR-20b-5p, miR-29a, and miR-18a-5p in Diabetes of Recent Diagnosis. +circulation_biomarker_diagnosis_ns 33072549 hsa-mir-29 Diabetes Mellitus Early-Onset Diabetes as Risk Factor for Pancreatic Cancer: miRNA Expression Profiling in Plasma Uncovers a Role for miR-20b-5p, miR-29a, and miR-18a-5p in Diabetes of Recent Diagnosis. +target gene 33072537 hsa-mir-193a Breast Neoplasms Restoring of miR-193a-5p Sensitizes Breast Cancer Cells to Paclitaxel through P53 Pathway. +genetics_GWAS 33072191 hsa-mir-146a Crohn Disease This study was designed to investigate the impact of polymorphisms in miR146a on the immune response and infection in our MAP-CD model. Finally, we analyzed the blood samples for MAP DNA and studied any correlation with miR-146a polymorphism. +transcription factor target 33072088 hsa-mir-31 Lung Injury Taken together, Mir3p/mir-210 have significant roles in the infection and lung injury caused by PRRSV-2, and they may be promising therapeutic targets for PRRS and lung injury/inflammation. +transcription factor target 33072088 hsa-mir-210 Lung Injury Taken together, Mir3p/mir-210 have significant roles in the infection and lung injury caused by PRRSV-2, and they may be promising therapeutic targets for PRRS and lung injury/inflammation. +target gene 33071785 hsa-mir-193a Melanoma Oleacein increased the levels of miR-193a-3p (targeting MCL1, c-KIT and K-RAS), miR-193a-5p (targeting PIK3R3 and mTOR), miR-34a-5p (targeting BCL2 and c-KIT) and miR-16-5p (miR-16-5p targeting BCL2, K-RAS and mTOR), while decreased miR-214-3p (targeting BAX). +target gene 33071785 hsa-mir-214 Melanoma Oleacein increased the levels of miR-193a-3p (targeting MCL1, c-KIT and K-RAS), miR-193a-5p (targeting PIK3R3 and mTOR), miR-34a-5p (targeting BCL2 and c-KIT) and miR-16-5p (miR-16-5p targeting BCL2, K-RAS and mTOR), while decreased miR-214-3p (targeting BAX). +target gene 33071785 hsa-mir-34a Melanoma Oleacein increased the levels of miR-193a-3p (targeting MCL1, c-KIT and K-RAS), miR-193a-5p (targeting PIK3R3 and mTOR), miR-34a-5p (targeting BCL2 and c-KIT) and miR-16-5p (miR-16-5p targeting BCL2, K-RAS and mTOR), while decreased miR-214-3p (targeting BAX). +target gene 33071785 hsa-mir-16 Melanoma Oleacein increased the levels of miR-193a-3p (targeting MCL1, c-KIT and K-RAS), miR-193a-5p (targeting PIK3R3 and mTOR), miR-34a-5p (targeting BCL2 and c-KIT) and miR-16-5p (miR-16-5p targeting BCL2, K-RAS and mTOR), while decreased miR-214-3p (targeting BAX). +genetics_knock down_promote 33071725 hsa-mir-214 Parkinson Disease CONCLUSION: Our current study first demonstrated the protective effect of SNHG14 knockdown on MPP(+)-stimulated cytotoxicity in SK-N-SH cells at least partially by targeting the miR +other 33071125 hsa-mir-222 Hematologic Diseases Changes in miR-222 expression, DNA repair capacity, and MDM2-p53 axis in association with low-dose benzene genotoxicity and hematotoxicity. +lncRNA target 33070965 hsa-mir-29c Leiomyoma CONCLUSION(S) Our data demonstrate that increased expression of XIST in leiomyoma results in reduced expression of miR-29c and miR-200c with a consequent up-regulation of the genes targeted by these microRNAs including COL1A1, COL3A1, and FN1, which play key roles in extracellular matrix accumulation associated with fibroids. +lncRNA target 33070965 hsa-mir-200c Leiomyoma CONCLUSION(S) Our data demonstrate that increased expression of XIST in leiomyoma results in reduced expression of miR-29c and miR-200c with a consequent up-regulation of the genes targeted by these microRNAs including COL1A1, COL3A1, and FN1, which play key roles in extracellular matrix accumulation associated with fibroids. +lncRNA target 33070767 hsa-mir-4262 Glioma CONCLUSION: LIFR-AS1 could suppress the proliferation, migration and invasion and promote the apoptosis through modulating miR-4262/NF-kappaB pathway in glioma. +other 33070521 hsa-mir-141 Multiple System Atrophy The results indicated that miR-214 could distinguish Parkinson's disease from the controls, and another 3 microRNAs could differentiate multiple system atrophy from the controls (miR-141, miR-193a-3p, and miR-30c). The expression of miR-31, miR-141, miR-181c, miR-193a-3p, and miR-214 were lower in multiple system atrophy than in Parkinson's disease (all P < 0.05). +other 33070521 hsa-mir-214 Multiple System Atrophy The results indicated that miR-214 could distinguish Parkinson's disease from the controls, and another 3 microRNAs could differentiate multiple system atrophy from the controls (miR-141, miR-193a-3p, and miR-30c). The expression of miR-31, miR-141, miR-181c, miR-193a-3p, and miR-214 were lower in multiple system atrophy than in Parkinson's disease (all P < 0.05). +other 33070521 hsa-mir-141 Parkinson Disease The results indicated that miR-214 could distinguish Parkinson's disease from the controls, and another 3 microRNAs could differentiate multiple system atrophy from the controls (miR-141, miR-193a-3p, and miR-30c). The expression of miR-31, miR-141, miR-181c, miR-193a-3p, and miR-214 were lower in multiple system atrophy than in Parkinson's disease (all P < 0.05). +other 33070521 hsa-mir-193a Parkinson Disease The results indicated that miR-214 could distinguish Parkinson's disease from the controls, and another 3 microRNAs could differentiate multiple system atrophy from the controls (miR-141, miR-193a-3p, and miR-30c). The expression of miR-31, miR-141, miR-181c, miR-193a-3p, and miR-214 were lower in multiple system atrophy than in Parkinson's disease (all P < 0.05). +other 33070521 hsa-mir-214 Parkinson Disease The results indicated that miR-214 could distinguish Parkinson's disease from the controls, and another 3 microRNAs could differentiate multiple system atrophy from the controls (miR-141, miR-193a-3p, and miR-30c). The expression of miR-31, miR-141, miR-181c, miR-193a-3p, and miR-214 were lower in multiple system atrophy than in Parkinson's disease (all P < 0.05). +other 33070521 hsa-mir-193a Multiple System Atrophy The results indicated that miR-214 could distinguish Parkinson's disease from the controls, and another 3 microRNAs could differentiate multiple system atrophy from the controls (miR-141, miR-193a-3p, and miR-30c). The expression of miR-31, miR-141, miR-181c, miR-193a-3p, and miR-214 were lower in multiple system atrophy than in Parkinson's disease (all P < 0.05). +other 33070258 hsa-mir-25 Heart Valve Diseases 3p expression in calcific valves. +other 33070258 hsa-mir-25 autosomal recessive congenital bilateral absence of vas deferens CONCLUSION: The findings indicated that TGFBR2/miR3p/TWIST1 axis regulates osteoblast differentiation in VICs, supporting the fact that TGFBR2 is a miRNA sponge in CAVD. +genetics_overexpression_promote 33070148 hsa-mir-101 Bronchopulmonary Dysplasia 3p to activate HMGB3, and overexpressed miR +other 33069761 hsa-mir-200a Fibrosis In conclusion, we demonstrated a lncRNA Gpr137b-ps/miR-200a-3p/CXCL14 axis that modulates HSC activation and might exert an effect on the pathogenesis of liver fibrosis. +lncRNA target 33069733 hsa-mir-1277 Fever This study intended to investigate the role of lncRNA nuclear enriched assembly transcript 1 (NEAT1) in MPP(+)-induced PD model in dopaminergic neuronblastoma SK-N-SH cells, as well as its mechanism through sponging miRNA (miR)5p. +lncRNA target 33069733 hsa-mir-1277 N acetyltransferase deficiency Moreover, silencing of miR5p could abrogate the suppression of NEAT1 deficiency on MPP(+)-induced cell injury. +lncRNA target 33069733 hsa-mir-1277 late onset Parkinson's disease This study intended to investigate the role of lncRNA nuclear enriched assembly transcript 1 (NEAT1) in MPP(+)-induced PD model in dopaminergic neuronblastoma SK-N-SH cells, as well as its mechanism through sponging miRNA (miR)5p. +genetics_knock down_promote 33069244 hsa-mir-577 Ovarian Neoplasms In addition, miR-577 was demonstrated to be a direct downstream target of LINC01094 in OC and inhibition of miR-577 reversed the biological effects of LINC01094 knockdown on OC cells. +transcription factor target 33068918 hsa-mir-674 Breast Neoplasms mir-3674 putatively targets ATF3, but its expression was significantly increased in human breast cancer cells (MDA-MB231), compared to normal human mammary epithelial cells (MCF-10A). +genetics_knock down_promote 33068702 hsa-mir-497 Depression Interestingly, knockdown miR-497 ameliorated CUS-induced depressive-like behavior in rats. +transcription factor target 33068587 hsa-mir-194 Liver Diseases, Alcoholic MiR-194 was upregulated in the alcoholic liver disease, which was significantly suppressed by Yan (P < 0.05). +transcription factor target 33068587 hsa-mir-194 Chemical and Drug Induced Liver Injury In summary, these aggregated data demonstrate that Yan alleviates chronic ethanol-induced liver injury through inhibition of cellular senescence via regulating miR-194/FXR axis. +circulation_biomarker_diagnosis_ns 33068460 hsa-mir-124 Cerebral Hemorrhage, Age-Related Higher serum miR-124 levels were correlated with poor neurologic scores of aged ICH patients. +other 33068176 hsa-mir-155 Breast Neoplasms RESULTS: MiRNA microarray analysis revealed miR-1246 and miR-155 were the most up-regulated miRs in trastuzumab-resistant HER2-positive breast cancer patients, which were further validated in trastuzumab-resistant patient samples (n = 32) compared with trastuzumab sensitive ones (n = 36). +other 33068176 hsa-mir-1246 Breast Neoplasms RESULTS: MiRNA microarray analysis revealed miR-1246 and miR-155 were the most up-regulated miRs in trastuzumab-resistant HER2-positive breast cancer patients, which were further validated in trastuzumab-resistant patient samples (n = 32) compared with trastuzumab sensitive ones (n = 36). +other 33068078 hsa-mir-548q Multiple Myeloma 5p, miR-548q, and miR-548y are potential noninvasive diagnostic biomarkers for MM. +other 33068078 hsa-mir-548y Multiple Myeloma 5p, miR-548q, and miR-548y are potential noninvasive diagnostic biomarkers for MM. +other 33068078 hsa-mir-134 Multiple Myeloma 5p, miR-548q, and miR-548y are potential noninvasive diagnostic biomarkers for MM. +other 33068078 hsa-mir-6500 Multiple Myeloma 5p, miR-548q, and miR-548y are potential noninvasive diagnostic biomarkers for MM. +circulation_biomarker_diagnosis_up 33067957 hsa-mir-224 Lymphoma, B-Cell RESULTS: The expression of miR-224 in blood of DLBCL patients was very significantly lower than that in normal control group (P<0.01). +other 33067956 hsa-mir-215 Lymphoma, Large B-Cell, Diffuse CONCLUSION There are low expression of miR-215 and high expression of KDM1B protein in patients with DLBCL suggesting that they may be the diagnostic and prognostic indicators of DLBCL. +circulation_biomarker_diagnosis_up 33067948 hsa-mir-9 Precursor Cell Lymphoblastic Leukemia-Lymphoma The expression of Hsa-miR-9 in ALL children related with serum WBC, infiltrating lymph nodes, splenomegaly, and risk grade (P<0.05). +circulation_biomarker_diagnosis_down 33067576 hsa-mir-4488 Breast Neoplasms Furthermore, we identified miR-4488 as being significantly downregulated in serum EVs from patients with triple-negative BC. +lncRNA target 33067424 hsa-mir-18b Gallbladder Neoplasms Moreover, HIF1A was proved to be the downstream target gene of miR-18b-5p and PVT1 regulated GBC cells proliferation via HIF1A. In conclusion, our studies clarified the PVT1/miR-18b-5p/HIF1A regulation axis and indicated that PVT1 could be a potential therapeutic target for GBC. +circulation_biomarker_diagnosis_ns 33067422 hsa-mir-449b Colorectal Neoplasms Mechanistically, cytoplasmic LINC01106 positively modulated Gli4 in CRC cells by serving as a miR-449b-5p sponge. +other 33067103 hsa-mir-206 Radiation Injuries CONCLUSIONS: EVs can be used as biomimetic nanovehicles for protective immunomodulation by enriching them with antagomiR-206 to mitigate epithelial cell activation and neutrophil infiltration in the lungs after IR injury. +other 33067103 hsa-mir-206 Lung Diseases Treatment with antagomiR-206enriched EVs attenuated lung dysfunction, injury, and edema compared with treatment with EVs alone after murine lung IR injury. +other 33067103 hsa-mir-206 Edema Treatment with antagomiR-206enriched EVs attenuated lung dysfunction, injury, and edema compared with treatment with EVs alone after murine lung IR injury. +other 33067103 hsa-mir-206 Wounds and Injuries CONCLUSIONS: EVs can be used as biomimetic nanovehicles for protective immunomodulation by enriching them with antagomiR-206 to mitigate epithelial cell activation and neutrophil infiltration in the lungs after IR injury. +other 33067103 hsa-mir-206 Neutropenia CONCLUSIONS: EVs can be used as biomimetic nanovehicles for protective immunomodulation by enriching them with antagomiR-206 to mitigate epithelial cell activation and neutrophil infiltration in the lungs after IR injury. +other 33067103 hsa-mir-206 Insulin Resistance CONCLUSIONS: EVs can be used as biomimetic nanovehicles for protective immunomodulation by enriching them with antagomiR-206 to mitigate epithelial cell activation and neutrophil infiltration in the lungs after IR injury. +lncRNA target 33066828 hsa-mir-145 Uterine Diseases OBJECTIVES: Aim of this study is to explore whether quercetin can inhibit the enlarged fibrogenic responses of endometrial stromal cells by increasing the level of microRNA-145 (miR-145) and mediating the TGFbeta1/Smad2/Smad3 signaling pathway, and to discuss the mechanism of signal transduction, further to provide experimental basis for revealing the pathophysiological mechanism and seeking new strategies for effective prevention and treatment of endometrial fibrosis. CONCLUSIONS: These findings indicated that quercetin have a significant anti-fibrotic effect and could upregulate miR-145 and inhibit activation of TGF-beta1/Smad2/Smad3 pathway to regulate TGF-beta1 induced fibrogenic responses of endometrial stromal cells, which may serve as a potential therapeutic agent for endometrial fibrosis. +other 33066828 hsa-mir-145 Gynatresia RESULTS: The expression level of miR-145 was decreased, whereas TGFBR2 was increased in intrauterine adhesion tissue. +circulation_biomarker_diagnosis_ns 33066724 hsa-mir-34a Migraine Disorders 5p in peripheral blood mononuclear cells of subjects with EM (n=27) or CM-MO (n=28). +circulation_biomarker_diagnosis_ns 33066724 hsa-mir-382 Migraine Disorders 5p in peripheral blood mononuclear cells of subjects with EM (n=27) or CM-MO (n=28). +lncRNA target 33066614 hsa-let-7e Sarcoma The expression of let-7e and 4 of its target genes are potential prognostic biomarkers in high-risk localized intestinal GIST. +lncRNA target 33066497 hsa-mir-22 Obesity 3p in Huh7 hepatic cancer cells triggers, in contrast to our in vivo observations, a clear induction of a Warburg effect with an increased glycolysis and an inhibited mitochondrial respiration. +lncRNA target 33066497 hsa-mir-22 Non-alcoholic Fatty Liver Disease 3p in Huh7 hepatic cancer cells triggers, in contrast to our in vivo observations, a clear induction of a Warburg effect with an increased glycolysis and an inhibited mitochondrial respiration. +genetics_GWAS 33066457 hsa-mir-148a Hodgkin Disease In summary, we report that mir-148a is a novel tumor suppressor inactivated in cHL and that epigenetic silencing of miRNAs is a common phenomenon in cHL. +lncRNA target 33066331 hsa-mir-192 Melanoma 5p levels on CTLs after co-culture with hypoxic melanoma cells were inversely correlated with the cytotoxic activity of T cells and with ZEB2 mRNA expression, a validated immune-related target of miR +lncRNA target 33066037 hsa-mir-7 Lymphoma, Large-Cell, Anaplastic 5p) mimics) strategies, also triggered autophagy and potentiated the toxicity of TKI. +other 33065511 hsa-mir-658 Peri-Implantitis In this study, the LINC00968 and miR-3658 expression level was upregulated and downregulated in DPSCs and peri-implantitis DPSCs (pDPSCs) treated with bone morphogenic protein (BMP)2, respectively. +other 33065231 hsa-mir-342 dystonia 5 3p in the DSTR. +other 33065231 hsa-mir-543 dystonia 5 3p in the DSTR. +genetics_knock down_promote 33065089 hsa-mir-342 Diabetic Retinopathy MIAT knockdown inhibited pyroptosis in HRPCs, which was reinforced by cotreatment with miR +lncRNA target 33064974 hsa-mir-34a Diabetic Retinopathy Our findings suggest that miR-34a/SIRT1 axis could be a valuable target for DR therapies. +other 33064238 hsa-mir-217 Reperfusion Injury Downregulating miR5p could protect cardiomyocytes against ischemia/reperfusion (I/R) injury, but its role in restoring mitochondrial function of I/R-injured cardiomyocytes remained unclear. +genetics_overexpression_promote 33063711 hsa-mir-188 Choroidal Neovascularization Choroidal neovascularization development was reduced by overexpression of miR-155, miR +genetics_overexpression_promote 33063711 hsa-mir-150 Choroidal Neovascularization Choroidal neovascularization development was reduced by overexpression of miR-155, miR +genetics_overexpression_promote 33063711 hsa-mir-126 Choroidal Neovascularization Choroidal neovascularization development was reduced by overexpression of miR-155, miR +genetics_overexpression_promote 33063711 hsa-mir-1 Choroidal Neovascularization Choroidal neovascularization development was reduced by overexpression of miR-155, miR +genetics_overexpression_promote 33063711 hsa-mir-93 Choroidal Neovascularization Choroidal neovascularization development was reduced by overexpression of miR-155, miR +genetics_overexpression_promote 33063711 hsa-mir-23 Choroidal Neovascularization Choroidal neovascularization development was reduced by overexpression of miR-155, miR +genetics_overexpression_promote 33063711 hsa-mir-155 Choroidal Neovascularization Choroidal neovascularization development was reduced by overexpression of miR-155, miR +genetics_overexpression_promote 33063711 hsa-mir-24 Choroidal Neovascularization Choroidal neovascularization development was reduced by overexpression of miR-155, miR +genetics_overexpression_promote 33063711 hsa-mir-505 Choroidal Neovascularization Choroidal neovascularization development was reduced by overexpression of miR-155, miR +genetics_overexpression_promote 33063711 hsa-mir-342 Choroidal Neovascularization Choroidal neovascularization development was reduced by overexpression of miR-155, miR +genetics_overexpression_promote 33063711 hsa-mir-184 Choroidal Neovascularization Choroidal neovascularization development was reduced by overexpression of miR-155, miR +genetics_overexpression_promote 33063711 hsa-mir-195a Choroidal Neovascularization Choroidal neovascularization development was reduced by overexpression of miR-155, miR +transcription factor target 33063634 hsa-mir-503 Prostatic Neoplasms 5p-dependent manner by targeting STAT3. +circRNA target 33063376 hsa-mir-1254 Myocardial Infarction, Acute The circRNAs hsa_circ_0066439, hsa_circ_0081241, and hsa_circ_0122984 can regulate multiple signal pathways to participate in the AMI process through hsa-miR-1254, hsa-miR5p, and other miRNAs. +circRNA target 33063376 hsa-mir-28 Myocardial Infarction, Acute The circRNAs hsa_circ_0066439, hsa_circ_0081241, and hsa_circ_0122984 can regulate multiple signal pathways to participate in the AMI process through hsa-miR-1254, hsa-miR5p, and other miRNAs. +lncRNA target 33063118 hsa-mir-106b Colorectal Neoplasms In rescue experiment, miR-106b-5p partially reversed the function of FAT4 in CRC cells, thus playing a carcinogenic role by targeting FAT4 in the CRC cells. +transcription factor target 33062725 hsa-mir-373 Glioblastoma miR-373 is related to the biological development process of cancers, but there are no reports whether modulation on miR-373 could affect GBM development or modify the efficiency of chemo- or radiotherapy yet. Thus, our experimental data confirmed the fact that miR-373 could be a new therapeutic target to enhance the efficiency of chemo- or radiotherapy for clinical GBM patients. +other 33062700 hsa-mir-188 Atrial Fibrillation 5p-SPON1 interaction pairs may be involved in AF. +other 33062700 hsa-mir-455 Atrial Fibrillation 5p-SPON1 interaction pairs may be involved in AF. +other 33062604 hsa-mir-21 Colorectal Neoplasms Furthermore, RNA-seq revealed 490 differentially expressed genes, highlighting the reduction of interferon stimulated genes and proliferative signaling pathways (JAK-STAT, MAPK, and PI3K-AKT), as well as the induction of ferroptosis and miR-21 expression. +target gene 33062603 hsa-mir-155 Ovarian Neoplasms MicroRNA-155-5p Diminishes in Vitro Ovarian Cancer Cell Viability by Targeting HIF1α Expression. +circulation_biomarker_diagnosis_ns 33061998 hsa-mir-361 Hypertension, Pulmonary 3p level is lower in the plasma of PAH patients. +lncRNA target 33061856 hsa-mir-589 Laryngeal Neoplasms 5p worked as a tumor-inhibitor while TRAF6 functioned as a tumor-facilitator in laryngocarcinoma. +lncRNA target 33061854 hsa-mir-1307 Adenocarcinoma of Lung 5p targets TRAF3 and activates the NF-kappaB/MAPK pathway to promote proliferation in lung adenocarcinoma. +genetics_overexpression_promote 33061849 hsa-mir-4766 Stomach Neoplasms Overexpression of CXCL5 overturned those effects of miR +circRNA target 33061846 hsa-mir-346 Colorectal Neoplasms Hsa_circ_0026416 promotes the progression of CRC via the miR-346/NFIB axis and may represent a potential biomarker for diagnosis and therapy in CRC. +genetics_knock down_suppress 33061807 hsa-mir-6759 Esophageal Squamous Cell Carcinoma These data suggested that lnc-MCEI was an oncogenic lncRNA and lnc-MCEI knockdown enhanced chemosensitivity of ESCC cells to cisplatin by targeting miR5p /IGF2/PI3K/AKT axis. +genetics_knock down_promote 33061801 hsa-mir-550-1 Leukemia, Myeloid, Acute Using gain- and loss-of-function approaches, we were able to determine that miR +genetics_knock down_suppress 33061643 hsa-mir-212 Carcinoma, Non-Small-Cell Lung CONCLUSION: Our findings first identified that the knockdown of circNFIX, a highly expressed circRNA in NSCLC, exerted a repressive role in NSCLC malignant progression at least in part through targeting the miR +genetics_overexpression_promote 33061638 hsa-mir-93 Carcinoma, Endometrioid 5p overexpression or ZBTB7A silencing. +genetics_knock down_promote 33061633 hsa-mir-370 Thyroid Cancer, Papillary 3p inhibition reversed the inhibitory effects of circ_0058124 knockdown on PTC development, and LMO4 overexpression reversed the effect of miR +lncRNA target 33061631 hsa-mir-634 Uterine Cervical Neoplasms CONCLUSION: Hsa_circ_0084927 accelerated CC advancement via upregulating TPD52 via sponging miR-634, offering a new evidence to support hsa_circ_0084927 as a promising target for CC treatment. +target gene 33061629 hsa-mir-139 Triple Negative Breast Neoplasms MicroRNA-139 Suppresses the Tumorigenicity of Triple Negative Breast Cancer Cells by Targeting SOX8. +transcription factor target 33061628 hsa-mir-200c Colorectal Neoplasms EPM5 was a direct target of miR-200c and enriched in the consensus molecular subtype (CMS) 4 of CRC. CONCLUSION: Our data provide the first evidence that the curcumin inhibits EMT in CRC by upregulation of miR-200c and downregulation of EPM5, and the use of curcumin might be able to prevent or delay CRC progression. +circRNA target 33061624 hsa-mir-107 Lymphoma, Large B-Cell, Diffuse CONCLUSION: Results showed that the circRNA CircCFL1 could regulate the expression of HMGB1 through miR-107 to promote the proliferation and migration of DLBCL. +target gene 33061623 hsa-mir-144 Liver Neoplasms Long Noncoding RNA EBLN3P Promotes the Progression of Liver Cancer via Alteration of microRNA-144-3p/DOCK4 Signal. +lncRNA target 33061622 hsa-mir-543 Carcinoma, Non-Small-Cell Lung Mechanistically, it was confirmed that GATA6-AS1 impeded NSCLC cell proliferation and metastasis by adsorbing miR-543 and up-regulating the expression of RKIP. CONCLUSIONS: As a tumor suppressor, GATA6-AS1 participates in suppressing the progression of NSCLC by modulating the miR-543/RKIP axis. +genetics_knock down_promote 33061618 hsa-mir-758 Carcinoma, Renal Cell 3p knockdown. +target gene 33061617 hsa-mir-142 Uterine Cervical Neoplasms Circ_0084927 Facilitates Cervical Cancer Development via Sponging miR-142-3p and Upregulating ARL2. +target gene 33061615 hsa-mir-491 Breast Neoplasms Long Non-Coding RNA H19 Promotes Proliferation, Migration and Invasion and Inhibits Apoptosis of Breast Cancer Cells by Targeting miR-491-5p/ZNF703 Axis. +genetics_overexpression_promote 33061613 hsa-mir-33a Stomach Neoplasms CONCLUSION: Circ_ASAP2 overexpression promoted cell proliferation, migration and invasion, whereas inhibited cell apoptosis by upregulating CDK7 expression through binding to miR-33a-5p in GA-induced GC cells. +genetics_overexpression_promote 33061611 hsa-mir-139 Laryngeal Neoplasms 3p overexpression inhibited LCA development via regulating the KDM5B/SOX2 axis and inhibiting the Wnt/beta-catenin pathway. +genetics_knock down_promote 33061608 hsa-mir-211 Ovarian Neoplasms 5p targeted HOXC8, and HOXC8 overexpression could reverse the suppression effect of miR +lncRNA target 33061606 hsa-mir-30 Carcinoma, Non-Small-Cell Lung CONCLUSION: Depleting circPRKCA inhibited PDK1 to suppress NSCLC cell malignant behaviors through miR +lncRNA target 33061605 hsa-mir-382 Carcinoma, Non-Small-Cell Lung CONCLUSION: SNHG14 facilitated NSCLC progression by regulating SPIN1 expression via targeting miR +target gene 33061604 hsa-mir-186 Stomach Neoplasms CREB1 Suppresses Transcription of microRNA-186 to Promote Growth, Invasion and Epithelial-Mesenchymal Transition of Gastric Cancer Cells Through the KRT8/HIF-1α Axis. +circulation_biomarker_prognosis_up 33061602 hsa-mir-210 Colonic Neoplasms This research aimed to explore the predictive role of miR-210 in serum for recurrence and prognosis of CC patients with hepatic metastasis. +circulation_biomarker_prognosis_up 33061602 hsa-mir-210 Colorectal Neoplasms This research aimed to explore the predictive role of miR-210 in serum for recurrence and prognosis of CC patients with hepatic metastasis. +lncRNA target 33061594 hsa-mir-25 Osteosarcoma 3p functions as an oncogenic microRNA in osteosarcoma by targeting Merlin, and may serve as a potential therapeutic target for osteosarcoma. +lncRNA target 33061591 hsa-mir-1287 Carcinoma, Hepatocellular CONCLUSION: Circ_CDR1as depletion inhibits HCC cell proliferation and metastasis by miR-1287/Raf1 and MEK/ERK pathways, highlighting a promising molecular target for HCC treatment. +genetics_knock down_promote 33061579 hsa-mir-20a Prostatic Neoplasms RAB21 knockdown reversed the effects of miR-320a inhibition on PCa cells. +genetics_knock down_promote 33061574 hsa-mir-106b Colorectal Neoplasms CONCLUSION: Knockdown of PVT1 impaired cell proliferation, migration and invasion in CRCs via regulating miR-106b-5p/FJX1 axis, which provided a novel insight into the development of therapeutic strategies for CRC patients. +genetics_overexpression_promote 33061573 hsa-mir-375 Thyroid Cancer, Papillary Overexpression of miR-375 inhibited the proliferation, migration, invasion of PTC cells and reduced the expressions of N-Cadherin and Snail but promoted the cell apoptosis and increased E-cadherin expression, while miR-375 inhibitor produced opposite effects to overexpressed miR-375. +genetics_knock down_promote 33061572 hsa-mir-128 Uterine Cervical Neoplasms Knockdown of MIR4435-2HG Suppresses the Proliferation, Migration and Invasion of Cervical Cancer Cells via Regulating the miR-128-3p/MSI2 Axis in vitro. +exosome 33061571 hsa-mir-1236 Breast Neoplasms Adipose Mesenchymal Stem Cell-Derived Exosomal microRNA-1236 Reduces Resistance of Breast Cancer Cells to Cisplatin by Suppressing SLC9A1 and the Wnt/β-Catenin Signaling. +genetics_overexpression_promote 33061567 hsa-mir-133a Carcinoma, Hepatocellular Overexpression of miR-133a-3p suppressed HCC cell growth and invasion but promoted cell apoptosis via targeting CORO1C. +other 33061506 hsa-mir-15a Diabetes Mellitus, Type 2 The aim of the study was to evaluate the expression levels of miR-15a and miR-222 in diabetic, pre-diabetic, and healthy individuals. +other 33061506 hsa-mir-222 Diabetes Mellitus, Type 2 The aim of the study was to evaluate the expression levels of miR-15a and miR-222 in diabetic, pre-diabetic, and healthy individuals. +lncRNA target 33061459 hsa-mir-130a Carcinoma, Renal Cell CONCLUSION: Our results indicated a critical role for the HIF1A-AS2-miR-130a-5p axis in renal carcinoma progression, which may act as a promising diagnostic biomarker and a pivotal therapeutic target for renal carcinoma cures. +other 33061458 hsa-mir-196b Ovarian Neoplasms High Expression of miR-196b Predicts Poor Prognosis in Patients with Ovarian Cancer. +transcription factor target 33061457 hsa-mir-505 Carcinoma, Non-Small-Cell Lung Then, we confirmed the bioinformatic results with LUAD patient samples, and NET1 was shown to be a direct target of miR3p in a luciferase assay. +target gene 33061456 hsa-mir-335 Breast Neoplasms LINC01087 is Highly Expressed in Breast Cancer and Regulates the Malignant Behavior of Cancer Cells Through miR-335-5p/Rock1. +lncRNA target 33061455 hsa-mir-4766 Carcinoma, Hepatocellular 5p expression via PI3K/AKT/mTOR signaling pathway. +target gene 33061453 hsa-mir-24 Lung Neoplasms Long Non-Coding RNA GATA6-AS1 Sponges miR-324-5p to Inhibit Lung Cancer Cell Proliferation and Invasion. +exosome 33061450 hsa-mir-143 Lung Neoplasms CONCLUSION: The key findings of this study highlight the potential of the G-MDSC-derived exosomes and the miR3p/ITM2B axis as therapeutic targets and clinical indicators of lung cancer. +genetics_overexpression_promote 33061446 hsa-mir-449a Endometrial Neoplasms MiR-449a overexpression suppressed the proliferation, migration and invasion of EC cells. +therapeutic target 33061445 hsa-mir-134 Stomach Neoplasms By targeting YY1 signaling transduction, miR-134-5p and miR-384 can alter the growth and apoptosis of GC cells, which are promising targets for new therapeutics of GC. +therapeutic target 33061445 hsa-mir-384 Stomach Neoplasms By targeting YY1 signaling transduction, miR-134-5p and miR-384 can alter the growth and apoptosis of GC cells, which are promising targets for new therapeutics of GC. +target gene 33061442 hsa-mir-101 Breast Neoplasms MiR-101-3p and Syn-Cal14.1a Synergy in Suppressing EZH2-Induced Progression of Breast Cancer. +transcription factor target 33061435 hsa-mir-338 Glioma 3p inhibitor antagonized the effect of downregulation of OXSM on cell cycle and apoptosis of GBM cells. +transcription factor target 33061435 hsa-mir-338 Glioblastoma 3p inhibitor antagonized the effect of downregulation of OXSM on cell cycle and apoptosis of GBM cells. +other 33061434 hsa-mir-1299 Breast Neoplasms Circ_0006528 Contributes to Paclitaxel Resistance of Breast Cancer Cells by Regulating miR-1299/CDK8 Axis. +lncRNA target 33061430 hsa-mir-7 Esophageal Neoplasms 5p inhibited the tumorigenesis of EC via inactivating MAPK signaling pathway in vivo. +lncRNA target 33061429 hsa-mir-6071 Glioblastoma CONCLUSION: Our study demonstrated that miR-6071 could suppress cell proliferation, migration and invasion, as well as promote apoptosis through the inhibition of PI3K/Akt/mTOR pathway by binding to ULBP2 in GBM. +target gene 33061428 hsa-mir-421 Ovarian Neoplasms Targeting of KDM5A by miR-421 in Human Ovarian Cancer Suppresses the Progression of Ovarian Cancer Cells. +genetics_knock down_promote 33061425 hsa-mir-877 Carcinoma, Hepatocellular 5p could specially bind to YWHAZ, and its knockdown abated the suppressive effect of circ-BIRC6 depletion on HCC tumorigenesis. +lncRNA target 33061424 hsa-mir-543 Prostatic Neoplasms CONCLUSION: LncRNA MCM3AP-AS1 can promote the proliferation, migration and invasion abilities of PCa cells through regulating the miR3p/SLC39A10/PTEN axis, which suggests that lncRNA MCM3AP-AS1 might be a potential target for prostate cancer therapy. +lncRNA target 33061423 hsa-mir-626 Carcinoma, Hepatocellular Moreover, we observed that hsa_circ_0004018 interacted with miR-626/DKK3 and contributed to HCC cell proliferation and migration through inhibiting Wnt/beta-catenin signaling pathway in vitro. +genetics_overexpression_suppress 33061418 hsa-mir-623 Glioma Furthermore, our findings indicated that miR-623 overexpression or TRIM44 down-regulation impeded the proliferation and migratory ability of LN229 and U251MG glioma cells, and miR-623 attenuates TRIM44-induced EMT by directly targeting the 3'UTR of TRIM44, which could serve as preliminary research to identify potential therapeutic targets for future treatment of GBM. CONCLUSION: Overall, microRNA-623 inhibits epithelial-mesenchymal transition to attenuate glioma proliferation by targeting TRIM44. +other 33061374 hsa-mir-133a Bone Neoplasms OBJECTIVE: This study aimed to develop aptamer-anchored hyperbranched poly(amido amine) (HPAA) for the systemic delivery of miRNA-133a-3p and to evaluate its therapeutic potential against bone metastasis of prostate cancer in vivo and in vitro. CONCLUSION: This study provided an aptamer-anchored HPAA-loaded gene system to deliver miRNA-133a-3p for better therapeutic efficacy of bone metastasis of prostate cancer. +other 33061374 hsa-mir-133a Prostatic Neoplasms OBJECTIVE: This study aimed to develop aptamer-anchored hyperbranched poly(amido amine) (HPAA) for the systemic delivery of miRNA-133a-3p and to evaluate its therapeutic potential against bone metastasis of prostate cancer in vivo and in vitro. CONCLUSION: This study provided an aptamer-anchored HPAA-loaded gene system to deliver miRNA-133a-3p for better therapeutic efficacy of bone metastasis of prostate cancer. +other 33061292 hsa-mir-93 Myocardial Reperfusion Injury CONCLUSION: Pravastatin acts as a protector on myocardial ischemia reperfusion injury by regulating miR-93/Nrf2/ARE signaling pathway. +lncRNA target 33060778 hsa-mir-17 Stomach Neoplasms Moreover, in vivo and in vitro experimental results showed that cir-ITCH can act as a tumour suppressor to prevent gastric cancer tumourgenesis by sponging miR-17. In summary, cir-ITCH was shown to prevent gastric cancer tumourgenesis through the Wnt/beta-catenin signalling pathway by sequestering miR-17. +exosome 33060560 hsa-mir-23a Acute Lung Injury In summary, MSC-exosome transmitted miR-23a-3p and miR5p reversed the progression of LPS-induced lung injury and fibrosis through inhibiting NF-kappaB and hedgehog pathways via silencing Ikbkb and destabilizing IKKbeta. +exosome 33060560 hsa-mir-182 Acute Lung Injury In summary, MSC-exosome transmitted miR-23a-3p and miR5p reversed the progression of LPS-induced lung injury and fibrosis through inhibiting NF-kappaB and hedgehog pathways via silencing Ikbkb and destabilizing IKKbeta. +genetics_GWAS 33059751 hsa-mir-182 Carcinoma, Hepatocellular The aim of the current study was to investigate the associations between miR-182 single nucleotide polymorphisms and HCC risk in a southern Chinese population. Our results suggested that miR-182 polymorphism rs4541843 may contribute to the susceptibility to HCC. +lncRNA target 33059643 hsa-mir-133a Carcinoma, Non-Small-Cell Lung CONCLUSION: Our findings demonstrated that SNHG14 was involved in the development of DDP-resistance of A549/DDP cells through miR-133a/HOXB13 axis, which may present a path to novel therapeutic stratagems for DDP resistance of NSCLC. +lncRNA target 33059609 hsa-mir-203 Colorectal Neoplasms By constructing a protein-protein interaction (PPI) network of the targets of miR-203, ten crucial proteins and a significant network module were retrieved and found to serve important roles in the molecular pathogenesis of CRC. +transcription factor target 33059532 hsa-mir-486 Sneddon Syndrome miR3p has an important role in SN pacemaker activity by targeting HCN4, making it a potential target for therapeutic treatment of SN disease such as sinus tachycardia. +transcription factor target 33059532 hsa-mir-486 Tachycardia, Sinus miR3p has an important role in SN pacemaker activity by targeting HCN4, making it a potential target for therapeutic treatment of SN disease such as sinus tachycardia. +other 33059402 hsa-mir-150 Heart Failure 5p may represent a novel risk marker in HF with reduced ejection fraction. +transcription factor target 33059240 hsa-mir-506 Thyroid Cancer, Papillary 3p might have proliferation-suppressive function in PTC by inhibiting YAP1 expression and regulating YAP1-CDK2/Cy clin E1 cell cycle pathway. +lncRNA target 33059199 hsa-mir-146a Stillbirth As a result, decreased miR-146a correlated with the cytokine disorder in unexplained SA deciduae, and inhibition of miR-146a promoted pro-inflammatory response in healthy deciduae-derived DICs. +transcription factor target 33059199 hsa-mir-146a Cytokine Release Syndrome As a result, decreased miR-146a correlated with the cytokine disorder in unexplained SA deciduae, and inhibition of miR-146a promoted pro-inflammatory response in healthy deciduae-derived DICs. Upregulation of miR-146a inhibited the expression of the predicted molecules enriched in the TLR pathway and improved the cytokine disorder in unexplained SA deciduae-derived DICs. +lncRNA target 33059199 hsa-mir-146a Sjogren's Syndrome Collectively, miR-146a improves the decidual cytokine microenvironment by regulating the TLR pathway in unexplained SA, providing novel potential targets for further therapeutic research. +other 33059199 hsa-mir-146a Pregnancy Complications Decidual immune cells (DICs)-mediated cytokine microenvironment is involved in pregnancy and regulated by many microRNAs, but whether microRNA-146a-5p (miR-146a) regulate the decidual cytokine microenvironment and the potential mechanisms in unexplained SA pathogenesis have rarely been reported. +genetics_GWAS 33059056 hsa-mir-155 Carcinoma, Hepatocellular 5p was upregulated in LINC01189-overexpessed Huh7 and Hep3B cells to investigate their epigenetic correlation on HCC development regulation. +genetics_GWAS 33059056 hsa-mir-155 Hepatitis C 5p was upregulated in LINC01189-overexpessed Huh7 and Hep3B cells to investigate their epigenetic correlation on HCC development regulation. +transcription factor target 33059020 hsa-mir-15a Lung Neoplasms Our study unveiled a novel mechanism of miR-15a-5p in inhibiting metastasis of lung cancer cells by suppressing lipid metabolism via suppression of ACSS2 mediated acetyl-CoA activity and histone acetylation. +other 33058914 hsa-mir-33a Hyperlipidemias miR-33a may also play a key role in decreased HDL-C in postprandial lipemia. +other 33058914 hsa-mir-122 Hyperlipidemias KEY FINDINGS: Increased expressions of miR-122 and miR-33a and miR-122/30c ratio and decreased miR-30c expression were observed in fasting and postprandial period of HPR compared with NPR. +other 33058834 hsa-mir-874 Triple Negative Breast Neoplasms 3p sponge, thus modulating SOX2 positively. +genetics_GWAS 33058756 hsa-mir-128-1 Metabolic Diseases Antisense targeting and genetic ablation of miR +transcription factor target 33058690 hsa-mir-138 Bone Diseases The results from this study indicate miR5p as a new target for osteogenic differentiation of hBMSCs and the treatment of bone defects. +other 33058500 hsa-mir-203 Liver Cirrhosis In this study, fructose was found to promote zinc finger E-box binding homeobox 1 (ZEB1) nuclear translocation, decrease microRNA-203 (miR-203) expression, increase survivin, activate transforming growth factor beta1 (TGF-beta1)/Smad signalling, down-regulate E-cadherin, and up-regulate fibroblast specific protein 1 (FSP1), vimentin, N-cadherin and collagen I (COL1A1) in rat livers and BRL-3A cells, in parallel with fructose-induced liver fibrosis. Polydatin antagonized ZEB1 nuclear translocation to up-regulate miR-203, subsequently blocked survivin-activated TGF-beta1/Smad signalling, which were consistent with its protection against fructose-induced EMT and liver fibrosis. +genetics_overexpression_promote 33058436 hsa-mir-29 Osteosarcoma Overexpression of miR +transcription factor target 33058411 hsa-mir-181a Inflammation Previous study shows that miR-181a level is increased during sepsis; however, the mechanism is still unknown. miR-181a can be a potential target of controlling the inflammatory response during sepsis and has important clinical significance for the treatment and rehabilitation of septic patients. +transcription factor target 33058411 hsa-mir-181a Sepsis Previous study shows that miR-181a level is increased during sepsis; however, the mechanism is still unknown. miR-181a can be a potential target of controlling the inflammatory response during sepsis and has important clinical significance for the treatment and rehabilitation of septic patients. +other 33058302 hsa-mir-590 Carcinoma, Embryonal In the current study, RT-qPCR was used to determine the expression of miR3p in cardiomyocytes differentiated from the embryonic carcinoma cell line P19CL6. +genetics_overexpression_promote 33057875 hsa-mir-101 Thyroid Cancer, Papillary 3p inhibition and CLDN1 overexpression can reverse the affection of sh-XIST on migration and invasion of PTC cells inhibition. +lncRNA target 33057597 hsa-let-7g Glioblastoma In conclusion, our results suggested that NEAT1 promoted GSCs progression via NEAT1/let-7g-5p/MAP3K1 axis, which provided a depth insight into TMZ resistance mechanism. +lncRNA target 33057139 hsa-mir-155 Colorectal Neoplasms Collectively, the results of the present study emphasize the oncogenic function of BATF3 illustrated by the reinforcement the biological processes of proliferation, invasion, as well as the metastatic capacity of CRC cells through activating the S1PR1/p-STAT3/miR +lncRNA target 33057072 hsa-mir-455 Stevens-Johnson Syndrome 3p inhibitor. +transcription factor target 33054835 hsa-mir-22 Huntington Disease The intersected hub genes, SIRT1 and SUZ12, and their predicted target miRNAs, in particular miR3p and miR-19b, may be significantly associated with pre-HD. +transcription factor target 33054835 hsa-mir-19b Huntington Disease The intersected hub genes, SIRT1 and SUZ12, and their predicted target miRNAs, in particular miR3p and miR-19b, may be significantly associated with pre-HD. +genetics_overexpression_suppress 33054738 hsa-mir-142 Triple Negative Breast Neoplasms 3p deficiency or USP6NL overexpression fully abolished the inhibitory effect of LINC00689 silence on TNBC cellular behaviors. +circRNA target 33054543 hsa-mir-942 Breast Neoplasms In general, circular RNA hsa_circ_0001785 inhibits the proliferation, migration and invasion of BC cells by modulating the miR-942/SOCS3 signaling axis. +other 33054489 hsa-mir-33a Coronary Disease The present study aims to discover the effect of miR-33a-5p and NOMO1 on CHD. +genetics_knock down_promote 33054480 hsa-mir-339 Leukemia, Myeloid, Acute More importantly, inhibition of miR-339 can largely abolish the effect of LINC00467 knockdown on AML cells. +circulation_biomarker_prognosis_up 33054296 hsa-mir-210 Colorectal Neoplasms In addition, serum miR-21 and miR-210 in the CRC group (n = 18) after surgery were lower than those before surgery (p < 0.001). +circulation_biomarker_prognosis_up 33054296 hsa-mir-21 Colorectal Neoplasms In addition, serum miR-21 and miR-210 in the CRC group (n = 18) after surgery were lower than those before surgery (p < 0.001). +other 33054050 hsa-mir-223 Arthritis, Rheumatoid Transfections with pre-miRNA-223, -126 and -148a specifically modulated genes regulating inflammation, survival and migration whereas DICER depletion influenced the inflammatory profile of neutrophils. +other 33053498 hsa-mir-125b Osteosarcoma Our study discovers that Circ_0086996 acts as miR-125b-5p sponge to mediate the tumorigenicity, which could act as a potential biomarker for the osteosarcoma and provides a novel insight for the mechanism in osteosarcoma. +other 33053117 hsa-mir-545 Bone Diseases In conclusion, TUG1 accelerated the proliferation and differentiation of osteoblasts by sponging miR3p and increasing CNR2 expression, which might provide a new biomarker for bone diseases. +lncRNA target 33053114 hsa-mir-19b Polycystic Ovary Syndrome "However, the relationship between H19 and miR-19b in the development of PCOS is still unknown. In conclusion, our study indicated that lncRNA H19 acted as a ceRNA to bind to miR-19b via a ""sponge"" to regulate the effect of CTGF on KGN cells, which may play a vital role in PCOS." +genetics_knock down_promote 33052880 hsa-mir-7 Hepatoblastoma Overall, the knockdown of CDR1as significantly inhibited the proliferation and stemness of HB cells by reducing the sponge activity on miR +genetics_overexpression_promote 33052706 hsa-mir-519d Squamous Cell Carcinoma of Head and Neck CCND1 was the target gene of miR-519d-3p, and overexpressed CCND1 reversed the effects of upregulation of miR-519d-3p on suppressing the viability, proliferation, and cell cycle of OSCC cells. +genetics_overexpression_suppress 33052627 hsa-mir-885 Cholangiocarcinoma Mechanistically, overexpression of miR +circulation_biomarker_diagnosis_ns 33052368 hsa-mir-21 Vascular Diseases In addition, the developed QCM biosensor was very effective in the quantification of miR-21 in serum samples, so the proposed miRNA detection method offers great potential for the diagnosis of early disease, such as cancer and vascular diseases, and could be an excellent alternative for biological research and clinical diagnosis. +genetics_GWAS 33052248 hsa-mir-181a Myocardial Ischemia The present study tested the hypothesis that perinatal nicotine exposure (PNE) causes a gender-dependent increase in vulnerability of the heart to ischemia-reperfusion (I/R) injury and cardiac dysfunction in male rat offspring via reprogramming of the miRNA-181a (miR-181a)-mediated signaling pathway and that miR-181a antisense could rescue this phenotype. Conclusion: Our data suggest that PNE could induce a reprogramming of cardiac miR-181a expression/DNA methylation pattern, which epigenetically modulates ATR/TGF-beta/autophagy signaling pathways, leading to gender-dependent development of ischemia-sensitive phenotype in postnatal life. +lncRNA target 33052070 hsa-mir-155 Acute Lung Injury 5p could prove to be a potential future clinical application in alleviating sepsis-induced acute lung injury. +other 33051830 hsa-mir-193b Hepatoblastoma To the best of our knowledge, the association of RACGAP1, MKI67, FOXM1, SIN3A, miR-193b, and miR-760 with HB was reported for the first time. +lncRNA target 33051781 hsa-mir-216b Pancreatitis Because of the target, NEAT1, miR-216b, and MAP2K6 formed a competitive endogenous RNA (ceRNA) network. +other 33051753 hsa-mir-218 Osteoporosis Therefore, our findings suggest miR-218 as a putative novel therapeutic candidate in the context of osteoporosis and other bone metabolism-related diseases. +other 33051753 hsa-mir-218 Bone Diseases, Metabolic Therefore, our findings suggest miR-218 as a putative novel therapeutic candidate in the context of osteoporosis and other bone metabolism-related diseases. +other 33051664 hsa-mir-451 Acute Lung Injury Expression of 3 microRNAs (miR449b-3p, P 2-fold) in DKD patients compared to healthy controls and DM patients. +other 32982978 hsa-mir-5088 Diabetic Nephropathies 3p, and miR-4516) was up-regulated (>2-fold) in DKD patients compared to healthy controls and DM patients. +other 32982978 hsa-mir-498 Diabetic Nephropathies 3p, and miR-4516) was up-regulated (>2-fold) in DKD patients compared to healthy controls and DM patients. +other 32982978 hsa-mir-5007 Diabetic Nephropathies 3p, and miR-4516) was up-regulated (>2-fold) in DKD patients compared to healthy controls and DM patients. +lncRNA target 32982978 hsa-mir-4534 Diabetic Nephropathies Mir-4534 might affect the FoxO signaling pathway by targeting BNIP3, and is expected to become a new biomarker for the progression of type 2 DKD disease, which will provide further research on the pathogenesis of DKD. +other 32982978 hsa-mir-4687 Diabetic Nephropathies 3p, and miR-4516) was up-regulated (>2-fold) in DKD patients compared to healthy controls and DM patients. +other 32982978 hsa-mir-4516 Diabetic Nephropathies 3p, and miR-4516) was up-regulated (>2-fold) in DKD patients compared to healthy controls and DM patients. +other 32982978 hsa-mir-516b Diabetic Nephropathies The expressions of miR-4534 and miR-516b-5p correlated with trace proteinuria levels in the confirmation cohort. +other 32982978 hsa-mir-2117 Diabetic Nephropathies 3p, and miR-4516) was up-regulated (>2-fold) in DKD patients compared to healthy controls and DM patients. +other 32982978 hsa-mir-1275 Diabetic Nephropathies 3p, and miR-4516) was up-regulated (>2-fold) in DKD patients compared to healthy controls and DM patients. +genetics_overexpression_promote 32982800 hsa-mir-27b Obesity At the mRNA level, miR-27b overexpression downregulated the expression of Ppargamma, but upregulated that of lipid metabolism-associated factors such as heart-type fatty acid-binding protein (H-FABP), fatty acid transport protein 1 (FATP1), adipose triglyceride lipase (ATGL), and lipoprotein lipase (LPL), whereas miR-27b inhibition elicited the opposite effect; however, inhibition of miR-27b led to elevated cholesterol 7 alpha-hydroxylase (CYP7A1) and fatty acid translocase 36 (CD36) levels. +transcription factor target 32982764 hsa-mir-34c Aortic Valve Disease Taken together, miR-34c could inhibit osteogenic differentiation and calcification of VICs by suppressing the STC1/JNK signaling pathway in CAVD, making miR-34c a novel therapeutic target for the treatment of CAVD. +target gene 32982740 hsa-mir-16 Osteosarcoma miR-16-5p Suppresses Progression and Invasion of Osteosarcoma via Targeting at Smad3. +target gene 32982585 hsa-mir-496 Prostatic Neoplasms NNT-AS1 modulates prostate cancer cell proliferation, apoptosis and migration through miR-496/DDIT4 axis. +target gene 32982449 hsa-mir-125b Stomach Neoplasms The miRNA, miR-125b, Inhibited Invasion and Metastasis of Gastric-Cancer Cells by Triggering the STAT3 Signaling Pathway. +lncRNA target 32982425 hsa-mir-181a Carcinoma, Non-Small-Cell Lung Moreover, miR-181a-5p inhibitor abolished SNHG7 silencing induced inhibition on proliferation, migration and invasion in NSCLC. +target gene 32982424 hsa-mir-372 Osteosarcoma CircRNA Circ_0001721 Promotes the Progression of Osteosarcoma Through miR-372-3p/MAPK7 Axis. +target gene 32982421 hsa-mir-663a Osteosarcoma LncRNA GAS5 Regulates Osteosarcoma Cell Proliferation, Migration, and Invasion by Regulating RHOB via Sponging miR-663a. +genetics_knock down_promote 32982419 hsa-mir-370 Osteosarcoma Circ_0003496 functioned as a sponge of miR-370, and miR-370 mediated the regulatory effect of circ_0003496 depletion on DXR-resistant OS cell progression and DXR sensitivity. CONCLUSION: Our present work suggested that the knockdown of circ_0003496 suppressed OS progression and enhanced DXR sensitivity at least partially through modulating KLF12 expression via functioning as a miR-370 sponge, highlighting new opportunities for OS management. +genetics_knock down_promote 32982415 hsa-mir-145 Glioma 5p inhibition restored the effects of circTTBK2 knockdown on the malignant behaviors of glioma cells. +target gene 32982413 hsa-mir-431 Osteosarcoma MicroRNA-431-5p Inhibits the Tumorigenesis of Osteosarcoma Through Targeting PANX3. +target gene 32982411 hsa-mir-138 Stomach Neoplasms MiR-138-5p Inhibits the Proliferation of Gastric Cancer Cells by Targeting DEK. +genetics_overexpression_promote 32982409 hsa-mir-545 Colorectal Neoplasms In CRC cells, overexpression of MCM3AP-AS1 and miR-545 was achieved, while their overexpression did not affect the expression of each other. +lncRNA target 32982404 hsa-mir-148a Colorectal Neoplasms Additionally, miR-148a expression level was negatively associated with macrophage recruitment by colorectal cancer cells. CONCLUSION: miR-148a promoted the differentiation of M0 macrophages into anti-tumor classical activation type M1, and reduced TAM recruitment by targeting SIRPalpha to inhibit colorectal cancer cell viability. +lncRNA target 32982404 hsa-mir-148a Drug Hypersensitivity These anti-cancer effects of miR-148a were related to the down-regulation of SIRPalpha in macrophages, directly targeted by miR-148a. CONCLUSION: miR-148a promoted the differentiation of M0 macrophages into anti-tumor classical activation type M1, and reduced TAM recruitment by targeting SIRPalpha to inhibit colorectal cancer cell viability. +other 32982402 hsa-mir-543 Breast Neoplasms LncRNA PVT1 Regulates TRPS1 Expression in Breast Cancer by Sponging miR-543. +circulation_biomarker_diagnosis_ns 32982348 hsa-mir-151 Norrie disease 3p and Anxa2 in blood samples from DN patients and healthy controls was detected by RT-qPCR. +circRNA target 32982311 hsa-mir-127 Esophageal Squamous Cell Carcinoma 5p, and it has the potential to serve as a novel prognostic and therapeutic target for ESCC. +genetics_overexpression_promote 32982307 hsa-mir-590 Carcinoma, Hepatocellular 3p or forcing of HMGB2 could rescue the stimulation effects of PART1 overexpression on HCC cell behaviors. +target gene 32982304 hsa-mir-182 Carcinoma, Hepatocellular MicroRNA-182 Promotes Cell Migration by Targeting Programmed Cell Death 4 in Hepatocellular Carcinoma Cells. +lncRNA target 32982293 hsa-mir-3666 Squamous Cell Carcinoma of Head and Neck Further functional studies demonstrated that miR-3666 inhibited the growth of HNSCC cells by suppressing cell proliferation and promoting apoptosis. +other 32982288 hsa-mir-29a Ovarian Neoplasms circKRT7-miR-29a-3p-COL1A1 Axis Promotes Ovarian Cancer Cell Progression. +other 32982286 hsa-mir-613 Carcinoma, Non-Small-Cell Lung BACKGROUND: The abnormal expression of RMRP and miR-613 was respectively associated with the pathogenesis of lung cancer, but the role of the RMRP/miR-613 axis in NSCLC has not been studied. +genetics_knock down_promote 32982274 hsa-mir-185 Leukemia, Myeloid, Acute Expression of TUG1 was upregulated in AML patients and cells, and its knockdown repressed cell proliferation and glycolysis in AML cells in vitro by targeting miR-185. +lncRNA target 32982244 hsa-mir-382 Depression CONCLUSION: Through our experiments and analysis, we found that the associations between miR +other 32982175 hsa-mir-449c Reperfusion Injury, Cerebral Ischemia CONCLUSION: SNHG4 can regulate STAT6 and repress inflammation by adsorbing miR-449c-5p in microglia during cerebral ischemia-reperfusion injury. +lncRNA target 32982172 hsa-mir-455 Atherosclerosis Furthermore, downregulation of HOXA-AS3 notably inhibited the progression of atherosclerosis through mediation of miR +genetics_GWAS 32981813 hsa-mir-146a Atherosclerosis This study aimed to investigate the correlation between plasma miR-146a levels and subclinical atherosclerosis as measured by the carotid intima-media thickness (CIMT) and brachial-ankle pulse wave velocity (baPWV) in patients with newly diagnosed T2DM. +genetics_GWAS 32981813 hsa-mir-146a Diabetes Mellitus, Type 2 This study aimed to investigate the correlation between plasma miR-146a levels and subclinical atherosclerosis as measured by the carotid intima-media thickness (CIMT) and brachial-ankle pulse wave velocity (baPWV) in patients with newly diagnosed T2DM. +other 32981709 hsa-mir-199a Cardiomyopathies RESULTS: Six-hour cold ischemia significantly impaired myocardial function, increased cell death, and reduced miR-199a-3p in implanted hearts versus <1hr-I. +exosome 32981709 hsa-mir-199a Ischemia RESULTS: Six-hour cold ischemia significantly impaired myocardial function, increased cell death, and reduced miR-199a-3p in implanted hearts versus <1hr-I. MSC-CM and MSC-EVs increased cold ischemia-downregulated miR-199a-3p in donor hearts, whereas exosome-depletion neutralized this effect. +lncRNA target 32981678 hsa-mir-877 Carcinoma, Non-Small-Cell Lung Overall, we identified a novel NSCLC-related lncRNA, DNAH17-AS1 which may exert an oncogenic function via serving as a sponge for miR +genetics_overexpression_promote 32980991 hsa-mir-142 Glioma Interfering lncPCAT19/overexpression of miR +other 32980803 hsa-mir-1 Colorectal Neoplasms Here a convenient cascade isothermal amplification approach incorporating a G-quadruplex molecular beacon (G4MB) was established for achieving one-pot detection of multiple CRC miRNAs (miRNA-21, miRNA-92a, miRNA-31); this strategy incorporated a Bsu DNA polymerase (Bsu pol)-induced strand-displacement reaction and a Lambda exonuclease (lambdaexo)-aided recycling reaction. +other 32980803 hsa-mir-21 Colorectal Neoplasms Here a convenient cascade isothermal amplification approach incorporating a G-quadruplex molecular beacon (G4MB) was established for achieving one-pot detection of multiple CRC miRNAs (miRNA-21, miRNA-92a, miRNA-31); this strategy incorporated a Bsu DNA polymerase (Bsu pol)-induced strand-displacement reaction and a Lambda exonuclease (lambdaexo)-aided recycling reaction. +other 32980803 hsa-mir-92a Colorectal Neoplasms Here a convenient cascade isothermal amplification approach incorporating a G-quadruplex molecular beacon (G4MB) was established for achieving one-pot detection of multiple CRC miRNAs (miRNA-21, miRNA-92a, miRNA-31); this strategy incorporated a Bsu DNA polymerase (Bsu pol)-induced strand-displacement reaction and a Lambda exonuclease (lambdaexo)-aided recycling reaction. +genetics_knock down_suppress 32980684 hsa-mir-183 Uterine Diseases Loss and gain function of miR-183 in endometrial cell lines showed that miR-183 could inhibit cell migration, invasion and apoptosis. +lncRNA target 32980391 hsa-mir-429 Squamous Cell Carcinoma of Head and Neck CONCLUSION: Inhibition of MALAT1 was able to elevate miR-429 to suppress the progression of HSCC via reducing ZEB1. +lncRNA target 32979364 hsa-mir-155 Ventricular Premature Complexes We demonstrate that IS promotes the HASMCs phenotype switch by suppressing MGP expression via ROS/NF-kappaB/miR5p signaling and provide a new insight for the pathogenesis of IS-induced VC. +circulation_biomarker_diagnosis_up 32979189 hsa-mir-486 Diabetic Retinopathy 3p or TLR4-related oligonucleotides and plasmids to explore their functions in DR. +lncRNA target 32978505 hsa-mir-19b Shock, Hemorrhagic These findings suggest that inhibition of miR-19b may be a putative therapeutic avenue for mitigating post shock pulmonary endothelial dysfunction in hemorrhage shock. +transcription factor target 32978369 hsa-mir-361 Prostatic Neoplasms 3p can function via suppressing the expression of ARv7 and MKNK2 to maximally increase the Enz sensitivity, and targeting these newly identified Enz/miR +exosome 32978367 hsa-mir-193a Carcinoma, Non-Small-Cell Lung A549 and H1299 cell lines were screened out and their parent cells and drug-resistant cells were co-cultured with human bone marrow mesenchymal stem cells (BMSCs)-derived exosomes (BMSC-Exo) that had been transfected with miR-193a mimic or si-LRRC1 to detect the colony formation, migration, apoptosis, invasion and proliferation of NSCLC cells. +lncRNA target 32978168 hsa-mir-671 Lung Neoplasms Using an integrated screening approach, we found that miR5p reduces LUSC metastasis by inhibiting a circular RNA (circRNA), CDR1as. +lncRNA target 32977948 hsa-mir-582 Carcinoma, Hepatocellular 3p suppressed HCC progression via targeting DLX2. +lncRNA target 32977944 hsa-mir-149 Stomach Neoplasms Generally speaking, our results indicated that miR-149 contributes to resistance of 5-FU in gastric cancer via targeting TREM2 and regulating beta-catenin pathway. +lncRNA target 32977843 hsa-mir-141 Pancreatitis CONCLUSIONS: In conclusion, LncRNA H19 effectively increased the therapeutic efficacy of MSCs in rats with SAP via the miR +lncRNA target 32977843 hsa-mir-138 Pancreatitis CONCLUSIONS: In conclusion, LncRNA H19 effectively increased the therapeutic efficacy of MSCs in rats with SAP via the miR +lncRNA target 32977766 hsa-mir-877 Uterine Cervical Neoplasms CONCLUSION: HOXD-AS1 functions as a tumor-promoting lncRNA via the miR3p/FGF2 axis in CC. +other 32977497 hsa-mir-146 Rhinitis, Allergic To prepare a binary formulation delivering miRNA-146 and evaluate a nucleic acid nasal delivery system by investigating its pharmacodynamic effects in allergic rhinitis. +other 32977497 hsa-mir-146a Rhinitis, Allergic To prepare a binary formulation delivering miRNA-146 and evaluate a nucleic acid nasal delivery system by investigating its pharmacodynamic effects in allergic rhinitis. +other 32976959 hsa-mir-27b Granulomatous Disease, Chronic These observations indicate a possible role of miR-27b in impaired mitochondrial function in the chronic activation of alveolar macrophages by MWCNT and the development of chronic pulmonary granulomatous inflammation. +lncRNA target 32976381 hsa-mir-101 Lymphoma, Large B-Cell, Diffuse 3p upregulation exerted inhibition effects on the progression of DLBCL. +genetics_knock down_promote 32976214 hsa-mir-335 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma The current work suggested that CDKN2B-AS1 knockdown repressed the progression and enhanced ADR sensitivity of pediatric T-ALL at least partly through targeting miR +lncRNA target 32976115 hsa-mir-338 Carcinoma, Non-Small-Cell Lung 3p inhibitor abolished SBF2-AS1 silencing caused inhibition on the growth, migration and invasiveness of NSCLC cell. +lncRNA target 32975761 hsa-mir-151 Angelman Syndrome MiR-151 inhibited the apoptosis of endothelial cells in AS, and IL-17A was a new target for miR-151. +lncRNA target 32975519 hsa-mir-19a Multiple Myeloma CONCLUSION: miR-19a-3p promoted cell proliferation and inhibited cell apoptosis by degrading the target FBXO32 mRNA in multiple myeloma. +other 32975280 hsa-mir-124 Acute Lung Injury These findings indicate the potential of FA and miR-124 in the treatment of ALI. +lncRNA target 32975234 hsa-mir-18a Glioblastoma As a result, CASC2 was downregulated and miR-18a was upregulated in glioblastoma tumor tissues and cells (T98 and A172). Collectively, this study demonstrated that CASC2 served as tumor suppressor in glioblastoma by inhibiting cell growth, metastasis and EMT both in vitro and in vivo partially via CASC2- miR-18a axis. +genetics_overexpression_promote 32975231 hsa-mir-214 Papillomavirus Infections overexpressed. +circRNA target 32975228 hsa-mir-1294 Glioma In conclusion, downregulation of hsa_circ_0000936 sensitizes TMZ-resistant glioma cells to TMZ by sponging miR-1294, suggesting that hsa_circ_0000936 may be a potential target for overcoming the resistance of glioma cells to TMZ. +genetics_overexpression_suppress 32975076 hsa-mir-382 Glioma 5p overexpression on malignant biological behavior of human glioma U251 cells. +genetics_knock down_promote 32975015 hsa-mir-497 Osteoporosis MiR-497 restoration or LRG1 knockdown activated TGF-beta1/Smads signalling pathway, promoted viability and suppressed apoptosis of osteoblasts in osteoporosis. +other 32974919 hsa-mir-500a Glomerulonephritis, Membranous CONCLUSION: Circ_0000524/miR-500a-5p/CXCL16 pathway regulated podocyte apoptosis in MN. +other 32974790 hsa-mir-512 Breast Neoplasms 3p as a potential candidate marker for breast cancer diagnosis. +other 32974591 hsa-mir-483 Biliary Atresia These include miR-30 and the miR-23 cluster (liver and bile duct development) and miR-29, miR-483, miR-181, miR-199 and miR-200 (inflammation and fibrosis). +other 32974591 hsa-mir-29 Biliary Atresia These include miR-30 and the miR-23 cluster (liver and bile duct development) and miR-29, miR-483, miR-181, miR-199 and miR-200 (inflammation and fibrosis). +other 32974591 hsa-mir-181 Biliary Atresia These include miR-30 and the miR-23 cluster (liver and bile duct development) and miR-29, miR-483, miR-181, miR-199 and miR-200 (inflammation and fibrosis). +other 32974591 hsa-mir-23 Biliary Atresia These include miR-30 and the miR-23 cluster (liver and bile duct development) and miR-29, miR-483, miR-181, miR-199 and miR-200 (inflammation and fibrosis). +other 32974591 hsa-mir-200 Biliary Atresia These include miR-30 and the miR-23 cluster (liver and bile duct development) and miR-29, miR-483, miR-181, miR-199 and miR-200 (inflammation and fibrosis). +other 32974336 hsa-mir-132 Rett Syndrome In this regard, we evaluated the transcript and protein levels of MECP2/MeCP2E1 and E2 isoforms, BDNF/BDNF, and miR132 (both 3p and 5p strands) by real time RT-PCR, Western blot, and ELISA in four different regions of the human RTT brains and their age-, post-mortem delay-, and sex-matched controls. +transcription factor target 32974192 hsa-mir-483 Esophageal Squamous Cell Carcinoma Previously, we demonstrated that etoposide-induced 2.4-kb mRNA (EI24) is the target of miR3p, which promoted the growth, migration, and drug resistance in ESCC, suggesting that EI24 participates in repressing the tumorigenesis and progression of ESCC. +transcription factor target 32974191 hsa-mir-17 Carcinoma, Hepatocellular High stiffness stimulation significantly activated the miR5p/PTEN/PI3K/Akt signaling pathway in HCC cells via integrin beta1 and in turn resulted in MMP2 and MMP9 upregulation. +exosome 32974168 hsa-mir-124a Lung Neoplasms MiR-124a Regulates Extracellular Vesicle Release by Targeting GTPase Rabs in Lung Cancer. +lncRNA target 32974144 hsa-let-7c Breast Neoplasms In the present study, we screened out several miRNAs dysregulated in taxanes-resistant breast cancer samples and confirmed that two miRNAs (miR +lncRNA target 32974144 hsa-mir-335 Breast Neoplasms In the present study, we screened out several miRNAs dysregulated in taxanes-resistant breast cancer samples and confirmed that two miRNAs (miR +circRNA target 32974140 hsa-mir-578 Carcinoma, Hepatocellular Besides, hsa_circ_0005785 reversed the suppressive influence of miR-578 on HCC and accelerated tumor malignant progression through the miR-578/APRIL axis. Moreover, targeting to the hsa_circ_0005785/miR-578/APRIL regulatory pathway might be a promising diagnostic and therapeutic strategy for HCC clinical practice. +genetics_knock down_suppress 32973958 hsa-mir-519 Nasopharyngeal Carcinoma HOXA-AS2 was identified to directly bind to miR-519, whereas a miR-519 inhibitor significantly rescued the HOXA-AS2 knockdown-attenuated progression of NPC. In conclusion, the present study demonstrated that HOXA-AS2/miR-519/HIF-1alpha and/or HOXA-AS2/miR-519/PD-L1 may be a novel mechanism regulating the progression of NPC, which may facilitate the development of targeted clinical therapy. +lncRNA target 32973957 hsa-mir-26b Osteosarcoma In summary, to the best of our knowledge, the present study is the first to report that RAB31 is a target gene of miR-26b, and silencing of RAB31 may inhibit OS growth and progression. +genetics_knock down_promote 32973955 hsa-mir-16 Nasopharyngeal Carcinoma In addition, miR-16 was demonstrated to directly interact with KIF9-AS1 and inhibit KIF9-AS1 expression levels, whereas the miR-16 inhibitor rescued the effects of the KIF9-AS1-knockdown in NPC cells. +transcription factor target 32973937 hsa-mir-149 Alzheimer Disease 5p regulated KAT8 and H4K16ac expression in an AD cell model, which may be associated with the pathological process of AD; therefore, miRNA may serve as a potential drug target for AD. +other 32973881 hsa-mir-29 Peripheral Arterial Disease Interestingly, several miRs were similarly downregulated (e.g., miR3p, miR-29) or upregulated (e.g., miR-501, miR-92a) in all CRF conditions. +other 32973881 hsa-mir-542 Peripheral Arterial Disease Interestingly, several miRs were similarly downregulated (e.g., miR3p, miR-29) or upregulated (e.g., miR-501, miR-92a) in all CRF conditions. +other 32973881 hsa-mir-501 Peripheral Arterial Disease Interestingly, several miRs were similarly downregulated (e.g., miR3p, miR-29) or upregulated (e.g., miR-501, miR-92a) in all CRF conditions. +other 32973881 hsa-mir-92a Peripheral Arterial Disease Interestingly, several miRs were similarly downregulated (e.g., miR3p, miR-29) or upregulated (e.g., miR-501, miR-92a) in all CRF conditions. +other 32973563 hsa-mir-605 Non-Syndromic Tooth Agenesis Our study indicated that pre-miR-605 rs2043556 was associated with risk of non-syndromic tooth agenesis. +target gene 32973404 hsa-mir-34b Colonic Neoplasms LINC02418 promotes colon cancer progression by suppressing apoptosis via interaction with miR-34b-5p/BCL2 axis. +other 32973352 hsa-mir-27a Uterine Cervical Neoplasms PTENP1 was confirmed to decoy miR-27a-3p to upregulate EGR1 expression in cervical cancer cells. +other 32973329 hsa-mir-6831 Stomach Neoplasms 5p) in metastatic (M)-IMC compared to nonmetastatic (N)-IMC, or nonneoplastic gastric mucosa. +other 32973329 hsa-mir-6779 Stomach Neoplasms 5p) in metastatic (M)-IMC compared to nonmetastatic (N)-IMC, or nonneoplastic gastric mucosa. +other 32973329 hsa-mir-125a Stomach Neoplasms 5p) in metastatic (M)-IMC compared to nonmetastatic (N)-IMC, or nonneoplastic gastric mucosa. +other 32973329 hsa-mir-500a Stomach Neoplasms 5p) in metastatic (M)-IMC compared to nonmetastatic (N)-IMC, or nonneoplastic gastric mucosa. +other 32973329 hsa-mir-151b Stomach Neoplasms 5p) in metastatic (M)-IMC compared to nonmetastatic (N)-IMC, or nonneoplastic gastric mucosa. +other 32973329 hsa-mir-628 Stomach Neoplasms 5p) in metastatic (M)-IMC compared to nonmetastatic (N)-IMC, or nonneoplastic gastric mucosa. +other 32973329 hsa-mir-106b Stomach Neoplasms 5p) in metastatic (M)-IMC compared to nonmetastatic (N)-IMC, or nonneoplastic gastric mucosa. +other 32973329 hsa-mir-1587 Stomach Neoplasms 5p) in metastatic (M)-IMC compared to nonmetastatic (N)-IMC, or nonneoplastic gastric mucosa. +other 32973329 hsa-mir-3175 Stomach Neoplasms 5p) in metastatic (M)-IMC compared to nonmetastatic (N)-IMC, or nonneoplastic gastric mucosa. +other 32973233 hsa-mir-23a Hemolysis Our study indicates that the baseline expression of miRNA-206 could predict the response to strength training, while miRNA-23a could serve as a potential predictive marker of functional changes during physical inactivity in dialysis patients. +other 32973233 hsa-mir-206 Hemolysis Our study indicates that the baseline expression of miRNA-206 could predict the response to strength training, while miRNA-23a could serve as a potential predictive marker of functional changes during physical inactivity in dialysis patients. +genetics_overexpression_promote 32973101 hsa-mir-146a Glioblastoma Further, miR-146a overexpression significantly inhibited the proliferation and invasion of GBM patient-derived primary cells and increased their response to temozolomide (TMZ), both in vitro and in vivo. +other 32973073 hsa-mir-150 Diabetic Retinopathy CONCLUSION: These data suggest that decreased miR-150 caused by obesity or diabetic insults is not merely correlated to the disease progression, but it contributes to the retinal dysfunction and inflammation, as well as the development of DR. +other 32973073 hsa-mir-150 Endophthalmitis CONCLUSION: These data suggest that decreased miR-150 caused by obesity or diabetic insults is not merely correlated to the disease progression, but it contributes to the retinal dysfunction and inflammation, as well as the development of DR. +other 32973073 hsa-mir-150 Diabetes Mellitus, Type 2 CONCLUSION: These data suggest that decreased miR-150 caused by obesity or diabetic insults is not merely correlated to the disease progression, but it contributes to the retinal dysfunction and inflammation, as well as the development of DR. +other 32973073 hsa-mir-150 Obesity CONCLUSION: These data suggest that decreased miR-150 caused by obesity or diabetic insults is not merely correlated to the disease progression, but it contributes to the retinal dysfunction and inflammation, as well as the development of DR. +other 32972755 hsa-mir-130a Norrie disease Collectively, these findings highlighted that blocking MIAT/miR-130a-3p/TLR4 network play vital regulatory roles in mitigating HG-induced inflammation damage and apoptosis, thereby protecting podocyte from HG-stimulated injury, implying that MIAT might be a promising therapeutic strategy for developing effective treatments against DN progression. +other 32972721 hsa-mir-28 Osteomyelitis 3p as novel candidate biomarkers for infected tibial non-union diagnosis, suggesting that these differentially expressed miRNAs could be utilised as novel diagnostic and therapeutic tools to identify infected tibial non-union. +other 32972721 hsa-mir-345 Osteomyelitis 3p as novel candidate biomarkers for infected tibial non-union diagnosis, suggesting that these differentially expressed miRNAs could be utilised as novel diagnostic and therapeutic tools to identify infected tibial non-union. +other 32972721 hsa-mir-649 Osteomyelitis 3p as novel candidate biomarkers for infected tibial non-union diagnosis, suggesting that these differentially expressed miRNAs could be utilised as novel diagnostic and therapeutic tools to identify infected tibial non-union. +lncRNA target 32972352 hsa-mir-130a Breast Neoplasms CONCLUSION: Our findings indicate that miRNA-130a-5p is downregulated in BC tissues and may play a tumor suppressor role in patients with BC. +lncRNA target 32972302 hsa-mir-454 Pancreatic Carcinoma Our findings suggest that components of the MIR454-FAM83A-TSPAN1 axis may be valuable prognosis markers or therapeutic targets for pancreatic cancer.Abbreviations: AMPK: adenosine 5'-monophosphate (AMP)-activated protein kinase; APC: APC regulator of WNT signaling pathway; ATG: autophagy related; AXIN2: axin 2; BECN1: beclin 1; CCND1: cyclin D1; CSNK1A1/CK1alpha: casein kinase 1 alpha 1; CTNNB1/beta-catenin: catenin beta 1; DAPI: 4'6-diamino +other 32972039 hsa-mir-9 Double Outlet Right Ventricle We previously demonstrated that miR-9, a known metastamiR, is released by triple negative breast cancer (TNBC) cells to enhance the transition of normal fibroblasts (NFs) into cancer-associated fibroblast (CAF)-like cells. Overall, our results demonstrate that miR-9/EFEMP1 axis is crucial for the conversion of NFs to CAF-like cells under TNBC signaling. +other 32972039 hsa-mir-9 Triple Negative Breast Neoplasms Overall, our results demonstrate that miR-9/EFEMP1 axis is crucial for the conversion of NFs to CAF-like cells under TNBC signaling. +other 32971741 hsa-mir-25 Lung Neoplasms (4) Conclusions: miR3p may be a potential prognostic biomarker in non-small cell lung cancer. +other 32971215 hsa-mir-497 Coronary Artery Disease Top non-coding regulators of bone metabolism in CAC included miRNA 497-5p/195 and 106a-5p, and lncRNA FAM197Y7. +other 32971215 hsa-mir-195 Coronary Artery Disease Top non-coding regulators of bone metabolism in CAC included miRNA 497-5p/195 and 106a-5p, and lncRNA FAM197Y7. +lncRNA target 32970959 hsa-mir-4784 Carcinoma, Hepatocellular Meanwhile, miR-4784 inhibitor or restoration of SSRP1 could markedly attenuate the inhibitory effect of LINC01134 downregulation on HCC cells. +other 32970816 hsa-mir-610 Multiple Myeloma Real-time polymerase chain reaction was employed to detect the expressions of circ_0000142 and miR-610 in MM tissues and cell lines. In brief, circ_0000142 enhances the proliferation and metastasis of MM cells by modulating the miR-610/AKT3 axis. +genetics_overexpression_promote 32970287 hsa-mir-223 Diabetes Mellitus RESULTS: MiR223 expression was significantly overexpressed both in insulin-resistant 3T3L1 adipocytes compared to non-insulin resistant adipocytes and in human diabetic adipose tissue, compared to non-diabetics (P value < 0.01). +genetics_knock down_promote 32970285 hsa-mir-338 Nasopharyngeal Carcinoma CircZNF609 knockdown suppressed cell tumorigenesis in NPC via regulating miR +lncRNA target 32970185 hsa-mir-490 Glioblastoma mediated targeting of telomere maintenance could be therapeutically important in GBM. +genetics_overexpression_promote 32969763 hsa-mir-204 Carcinoma, Non-Small-Cell Lung After transfection of TMPO-AS1 shRNAs into NSCLC cells, the malignant phenotypes of NSCLC cells were significantly inhibited, while overexpression of TMPO-AS1 had opposite effects; TMPO-AS1 was also demonstrated to regulate the expression of miR +other 32969715 hsa-mir-27a Thyroid Neoplasms The authors aimed to evaluate the prognostic value of miRNA-27a (miR-27a), peroxisome proliferator-activated receptor alpha/gamma (PPARalpha/gamma) and retinoid X receptor alpha (RXRalpha) tissue expression in patients with thyroid carcinoma. Both miR-27a and PPARalpha/RXRalpha showed association with different poor prognostic indices in thyroid cancer patients. +lncRNA target 32968928 hsa-mir-326 Parkinson Disease Collectively, HOTAIR silencing significantly inhibits neuronal damage through repressing NLRP3 mediated pyroptosis activation via regulation of miR-326/ELAVL1 axis in PD, which may contribute to a better understanding of PD pathogenesis and provide new treatment strategies for this disease. +transcription factor target 32968640 hsa-mir-181c Cardiovascular Diseases CONCLUSIONS: Our study revealed that miR-181c protected heart failure by impeding cardiomyocyte apoptosis through PI3K/Akt pathway, implying the therapeutic role of miR-181c during the exacerbation of the cardiovascular disease. +transcription factor target 32968640 hsa-mir-181c Heart Failure RESULTS: It was revealed that miR-181c was suppressed on the heart tissue of DOX-induced heart failure animal model. CONCLUSIONS: Our study revealed that miR-181c protected heart failure by impeding cardiomyocyte apoptosis through PI3K/Akt pathway, implying the therapeutic role of miR-181c during the exacerbation of the cardiovascular disease. +lncRNA target 32968636 hsa-mir-186 Propofol Infusion Syndrome CONCLUSIONS: SNHG6/hsa-miR5p can modulate PPF-induced cardiac cytotoxicity in HiPSC-CMs, and thus may be a future drug target to prevent PPF infusion syndrome. +lncRNA target 32968636 hsa-mir-186 Cardiotoxicity 5p can modulate PPF-induced cardiac cytotoxicity in HiPSC-CMs, and thus may be a future drug target to prevent PPF infusion syndrome. +lncRNA target 32968636 hsa-mir-186 Heart Diseases 5p can modulate PPF-induced cardiac cytotoxicity in HiPSC-CMs, and thus may be a future drug target to prevent PPF infusion syndrome. +epigenetics 32968630 hsa-mir-181b Coronary Artery Disease CONCLUSIONS: Hypermethylation of miR-181b induces M1 polarization and promotes atherosclerosis through activation of PIAS1 and KLF4 SUMOylation in macrophages. +genetics_overexpression_promote 32968625 hsa-mir-374 Atherosclerosis CONCLUSIONS: The high expression of miR-374 may be a potential diagnostic marker for AS, and overexpression of miR-374 may play a role in AS by promoting the proliferation and migration of VSMCs. +lncRNA target 32968621 hsa-mir-221 Hypertension, Pulmonary Monocrotaline (MCT) induced-PAH rat model was established and miR-221 and TIMP3 levels were checked in lung tissue and PASMCs from PAH rats. MiR-221 and TIMP3 could be potential therapeutic targets for the treatment of PAH. +other 32968471 hsa-mir-146a Prostatic Neoplasms Reduced expression of miR-146a was observed in African American tumor tissues compared to those from European Whites +circulation_biomarker_diagnosis_ns 32968458 hsa-mir-130a Carcinoma, Non-Small-Cell Lung The results of the present study demonstrated that the expression levels of miR-130a, miR-25 and miR-191* in the serum of patients with NSCLC were increased compared with those in healthy controls, and these increases were associated with advanced age (>/=60 years), radiotherapy, histological type (squamous carcinoma), low survival rate and low median survival time. +circulation_biomarker_diagnosis_ns 32968458 hsa-mir-25 Carcinoma, Non-Small-Cell Lung The results of the present study demonstrated that the expression levels of miR-130a, miR-25 and miR-191* in the serum of patients with NSCLC were increased compared with those in healthy controls, and these increases were associated with advanced age (>/=60 years), radiotherapy, histological type (squamous carcinoma), low survival rate and low median survival time. +circulation_biomarker_diagnosis_ns 32968458 hsa-mir-191 Carcinoma, Non-Small-Cell Lung The results of the present study demonstrated that the expression levels of miR-130a, miR-25 and miR-191* in the serum of patients with NSCLC were increased compared with those in healthy controls, and these increases were associated with advanced age (>/=60 years), radiotherapy, histological type (squamous carcinoma), low survival rate and low median survival time. +genetics_overexpression_promote 32968457 hsa-mir-181a Glioblastoma Flow cytometry analysis was carried out to determine whether overexpression of miR-181a-5p can promote the apoptotic rate of GBM cells. +genetics_overexpression_promote 32968457 hsa-mir-181a Carcinoma, Non-Small-Cell Lung Flow cytometry analysis was carried out to determine whether overexpression of miR-181a-5p can promote the apoptotic rate of GBM cells. +transcription factor target 32968455 hsa-mir-1911 Carcinoma, Hepatocellular In addition, PAK4, heat shock protein 105 kDa and miRNA-1911 were demonstrated to be a key factor involved in immune response via Weighted Correlation Network Analysis in HCC. +genetics_overexpression_promote 32968448 hsa-mir-615 Osteosarcoma In addition, overexpression of miR-615 restrained cell viability and metastasis in OS. +lncRNA target 32968445 hsa-mir-3690 Thyroid Neoplasms Collectively, the findings of the present study demonstrated that miR-3690 promoted TC cell proliferation and indicated miR-3690 as a potential biomarker and therapeutic target for TC. +circulation_biomarker_prognosis_ns 32968443 hsa-mir-155 Diabetic Nephropathies Urine VDBP and serum miR +genetics_overexpression_suppress 32968442 hsa-mir-503 Carotid Stenosis 5p is a potential diagnostic biomarker for asymptomatic CAS and overexpression of miR +other 32968066 hsa-mir-106b Inflammation These findings confirm macrophage miR-106b-5p secretion from impaired vitamin D receptor signaling causes inflammation-induced hypertension. +transcription factor target 32968049 hsa-mir-96 Osteoporosis 5p-PIK3R1 axis led to dysfunction of osteoporotic BMSCs and might be a novel therapeutic target for stem cell therapy and tissue regeneration. +circulation_biomarker_diagnosis_up 32967763 hsa-mir-93 Triple Negative Breast Neoplasms 5p inhibitor plasmid up-regulated the expression of FGD5 in TNBC cells. +lncRNA target 32967672 hsa-mir-146a Melanoma RESULTS: miR-146a-5p expression was inversely correlated with drug sensitivity and COX2 expression and was reduced in BRAF and MEK inhibitor-resistant melanoma cells and tissues. +lncRNA target 32967481 hsa-mir-10a Osteoarthritis RESULTS: SNHG5 and H3F3B were downregulated, while miR-10a-5p was upregulated in OA cartilage tissues. CONCLUSION: SNHG5 suppressed chondrocytes apoptosis in OA by regulating the miR-10a-5p/H3F3B axis, which provided a promising biomarker for OA treatment. +transcription factor target 32966836 hsa-mir-155 Meningitis, Fungal cantonensis infection and that miR5p inhibition might provide a novel strategy to attenuate eosinophilic meningitis. +other 32966618 hsa-mir-223 Brain Death RESULTS: A decrease in miR-223 and an increase in NLRP3 in HDPT occurred during the transformation of reversible pulpitis into irreversible pulpitis compared to that in healthy pulp tissue (P < 0.05). +other 32966618 hsa-mir-223 Pulpitis RESULTS: A decrease in miR-223 and an increase in NLRP3 in HDPT occurred during the transformation of reversible pulpitis into irreversible pulpitis compared to that in healthy pulp tissue (P < 0.05). +other 32966618 hsa-mir-223 Hyperparathyroidism, Neonatal Severe Primary RESULTS: A decrease in miR-223 and an increase in NLRP3 in HDPT occurred during the transformation of reversible pulpitis into irreversible pulpitis compared to that in healthy pulp tissue (P < 0.05). +other 32965722 hsa-mir-627 Carcinoma, Non-Small-Cell Lung Let-7a-5p, miR-338, miR-375, miR-217, miR-627, miR-140, miR-147b, miR2, miR-584, and miR-197 are top 10 relevant miRNAs and CLDN3, DSG3, KRT17, TMEM125, KRT5, NKX2-1, KRT7, ABCC5, KRAS, and PLCG2 are top 10 relevant genes in NSCLC. +other 32965722 hsa-mir-147b Carcinoma, Non-Small-Cell Lung Let-7a-5p, miR-338, miR-375, miR-217, miR-627, miR-140, miR-147b, miR2, miR-584, and miR-197 are top 10 relevant miRNAs and CLDN3, DSG3, KRT17, TMEM125, KRT5, NKX2-1, KRT7, ABCC5, KRAS, and PLCG2 are top 10 relevant genes in NSCLC. +other 32965722 hsa-let-7a Carcinoma, Non-Small-Cell Lung Let-7a-5p, miR-338, miR-375, miR-217, miR-627, miR-140, miR-147b, miR2, miR-584, and miR-197 are top 10 relevant miRNAs and CLDN3, DSG3, KRT17, TMEM125, KRT5, NKX2-1, KRT7, ABCC5, KRAS, and PLCG2 are top 10 relevant genes in NSCLC. +other 32965722 hsa-mir-140 Carcinoma, Non-Small-Cell Lung Let-7a-5p, miR-338, miR-375, miR-217, miR-627, miR-140, miR-147b, miR2, miR-584, and miR-197 are top 10 relevant miRNAs and CLDN3, DSG3, KRT17, TMEM125, KRT5, NKX2-1, KRT7, ABCC5, KRAS, and PLCG2 are top 10 relevant genes in NSCLC. +lncRNA target 32965722 hsa-mir-338 Carcinoma, Non-Small-Cell Lung Among the differential expressed miRNAs, let-7a-5p was significantly down-regulated in LUAD while miR-338 was markedly down-regulated in LUSC. And NK2 homeobox 1(NKX2-1) which was associated with tumor progression in LUSC was identified as a target gene of miR-338. +other 32965722 hsa-mir-197 Carcinoma, Non-Small-Cell Lung Let-7a-5p, miR-338, miR-375, miR-217, miR-627, miR-140, miR-147b, miR2, miR-584, and miR-197 are top 10 relevant miRNAs and CLDN3, DSG3, KRT17, TMEM125, KRT5, NKX2-1, KRT7, ABCC5, KRAS, and PLCG2 are top 10 relevant genes in NSCLC. +other 32965722 hsa-mir-217 Carcinoma, Non-Small-Cell Lung Let-7a-5p, miR-338, miR-375, miR-217, miR-627, miR-140, miR-147b, miR2, miR-584, and miR-197 are top 10 relevant miRNAs and CLDN3, DSG3, KRT17, TMEM125, KRT5, NKX2-1, KRT7, ABCC5, KRAS, and PLCG2 are top 10 relevant genes in NSCLC. +other 32965722 hsa-mir-375 Carcinoma, Non-Small-Cell Lung Let-7a-5p, miR-338, miR-375, miR-217, miR-627, miR-140, miR-147b, miR2, miR-584, and miR-197 are top 10 relevant miRNAs and CLDN3, DSG3, KRT17, TMEM125, KRT5, NKX2-1, KRT7, ABCC5, KRAS, and PLCG2 are top 10 relevant genes in NSCLC. +other 32965722 hsa-mir-138-2 Carcinoma, Non-Small-Cell Lung Let-7a-5p, miR-338, miR-375, miR-217, miR-627, miR-140, miR-147b, miR2, miR-584, and miR-197 are top 10 relevant miRNAs and CLDN3, DSG3, KRT17, TMEM125, KRT5, NKX2-1, KRT7, ABCC5, KRAS, and PLCG2 are top 10 relevant genes in NSCLC. +genetics_knock down_promote 32965597 hsa-mir-129 Carcinoma, Hepatocellular 5p released the functional effect of MALAT1 knockdown. +transcription factor target 32965580 hsa-mir-137 Colorectal Neoplasms DCLK1, a promising colorectal cancer stem cell marker, regulates tumor progression and invasion through miR-137 and miR-15a dependent manner. +transcription factor target 32965580 hsa-mir-15a Colorectal Neoplasms DCLK1, a promising colorectal cancer stem cell marker, regulates tumor progression and invasion through miR-137 and miR-15a dependent manner. +other 32965161 hsa-mir-27a Scleroderma, Systemic Modulation of microRNA27a-3p levels could mediate fibrosis regression. +other 32965005 hsa-mir-140 Angelman Syndrome CONCLUSIONS: MiR-140a serves as a pro-atherosclerotic microRNA by modulating the phenotypic switch of AS-associated macrophages. +circulation_biomarker_diagnosis_ns 32964994 hsa-mir-492 Myocardial Infarction, Acute CONCLUSIONS: Serum level of miR-492 remarkably increases in the acute phase of AMI, which may be used as an effective biomarker for diagnosing AMI. +lncRNA target 32964992 hsa-mir-29a Hypertension, Pulmonary RESULTS: MIAT was upregulated in both in vivo and in vitro HPH models, while miR-29a-5p was downregulated. CONCLUSIONS: MIAT promotes proliferative and migratory abilities, as well as oxidative stress in hypoxia-induced HPAECs by targeting miR-29a-5p, thus aggravating the development of HPH. +other 32964988 hsa-mir-640 Inflammation Previous studies have shown that miR-640 is a valid regulator of the Low-density lipoprotein receptor-related protein 1 (LRP 1) which expressed much lower in an inflammatory condition. +other 32964988 hsa-mir-640 Chemical and Drug Induced Liver Injury To explore the regulated mechanism of miR-640 on acute liver injury. +lncRNA target 32964988 hsa-mir-640 Acute Lung Injury MiR-640 inhibition may become a novel target for the therapy of ALI in the future. +other 32964988 hsa-mir-640 Acute Disease MATERIALS AND METHODS: We analyzed the expression of miR-640 in different times of acute injured liver tissues. RESULTS: We showed that the expression of miR-640 markedly increased in LPS-induced acute injured liver tissues. +genetics_overexpression_promote 32964983 hsa-mir-362 Glioblastoma Functionally, overexpression of miR-362 inhibited the proliferation and metastasis of GBM cells. +lncRNA target 32964975 hsa-mir-203b Nasopharyngeal Carcinoma CONCLUSIONS: LINC00887 promotes the proliferative ability in NPC via absorbing miRNA-203b-3p to upregulate NUP205. +circRNA target 32964974 hsa-mir-106b Esophageal Squamous Cell Carcinoma MiR-106b participated in hsa_circ_RNA0023397-mediated inhibition of proliferation of esophageal cancer KYSE-150 cells. CONCLUSIONS: Hsa_circ_RNA0023397 is down-regulated in esophageal cancer cells and can act as miR-106b to affect the biological function of esophageal cancer cells. +lncRNA target 32964973 hsa-mir-574 Stomach Neoplasms CONCLUSIONS: In this research, we discovered that circRNA_100782 was downregulated in gastric cancer cells and is associated with cell proliferation and invasion by inhibiting tumor suppressor gene Rb by interacting with miR +other 32964970 hsa-mir-766 Stomach Neoplasms CONCLUSIONS: Our study shows for the first time that the highly expressed microRNA-766 in tumor tissues of patients with stage GCa predicts better platinum-containing chemotherapy efficacy and prognosis. +lncRNA target 32964969 hsa-mir-543 Colorectal Neoplasms CONCLUSIONS: MiR-543 participated in cell proliferation and metastasis by targeting PIAS3 in CRC. +other 32964968 hsa-mir-4730 Pancreatic Carcinoma CONCLUSIONS: For patients with pancreatic cancer, those with low miR-4730 expression have poor survival and prognoses, so miR-4730 can be used as a potential observational index for the prognosis and diagnosis of the disease. +lncRNA target 32964967 hsa-mir-138 Carcinoma, Hepatocellular Finally, our results showed that re-expression of FOXC1 rescued the growth and metastatic-related traits of HCC cell inhibited by miR +other 32964966 hsa-mir-222 Carcinoma, Hepatocellular RESULTS: We found high expression of lncRNA DANCR and ATG7, and low expression of miR3p in HCC tissues and cell lines. +lncRNA target 32964965 hsa-mir-125b Liver Neoplasms CONCLUSIONS: For the first time, we found that RIZ1 was upregulated in liver cancer cells and RIZ1-mediated H3K9me1 enrichment on the HOTAIRM1 promoter regulated the growth and metastasis of liver cancer cells by targeting miR-125b, which could further accelerate tumor proliferation, migration and invasion. +other 32964964 hsa-mir-5590 Carcinoma, Renal Cell 3p regulated clear cell proliferation and metastasis in RCC. +lncRNA target 32964961 hsa-mir-320c Uterine Cervical Neoplasms CONCLUSIONS: MiR-320c is capable of inhibiting migratory potential in cervical cancer by targeting GABRP, which may be utilized as a therapeutic target of cervical cancer. +lncRNA target 32964960 hsa-mir-4429 Ovarian Neoplasms By negatively regulating YOD1 level, miR-4429 suppresses the malignant development of ovarian cancer. +genetics_overexpression_promote 32964959 hsa-mir-1 Ovarian Neoplasms 3p is under expressed either in OVC tissues or in cell lines, and overexpression of microRNA +other 32964951 hsa-mir-126 Glaucoma In model group and miR-126 antagomir group, the rats were used to establish glaucoma models and intervened with normal saline and miR-126 antagomir, respectively. CONCLUSIONS: MiR-126 facilitates the apoptosis of retinal ganglion cells in glaucoma rats by promoting the VEGF-Notch signaling pathway. +lncRNA target 32964943 hsa-mir-210 Cerebral Infarction "The Editorial Board of European Review for Medical and Pharmacological Sciences would like to issue an Expression of Concern for ""MiR-210 suppresses neuronal apoptosis in rats with cerebral infarction through regulating VEGF-notch signaling pathway"", by Y.-L." +lncRNA target 32964916 hsa-mir-223 Precursor Cell Lymphoblastic Leukemia-Lymphoma CONCLUSIONS: miR-223 could inhibit cell proliferation, migration and invasion, and promote apoptosis by targeting FOXO1 in ALL. +genetics_knock down_promote 32964288 hsa-mir-1271 Glioma Functional experiments suggested that knockdown of ZFAS1 or upregulation of miR +genetics_overexpression_promote 32964047 hsa-mir-29a Atherosclerosis CONCLUSION: miR-29a-3p overexpression ameliorated plaque formation of AS and suppressed proliferation, migration, and invasion of ox-LDL-induced VSMCs via TNFRSF1A, which offered novel insights into the progression of AS. +genetics_knock down_promote 32964035 hsa-mir-211 Carcinoma, Non-Small-Cell Lung Overexpression or knockdown of miR-211 suppressed or induced SRCIN1 levels in NSCLC. Moreover, we found that miR-211 affected NSCLC cell proliferation through SRCIN1. +genetics_overexpression_promote 32964027 hsa-mir-587 Carcinoma, Hepatocellular Moreover, miR-587 overexpression directly suppressed RPSA expression, and the two genes were inversely expressed in HCC based on the analyses in TCGA and GEO (GSE36376) databases and qPCR analysis of 86 paired clinical tissues. +genetics_overexpression_promote 32964023 hsa-mir-19 Gastrointestinal Neoplasms miR-19 levels in gastrointestinal malignancy, especially in hepatocellular (OR = 4.88, 95% CI = 2.38-9.99), colorectal (OR = 4.81, 95% CI = 2.38-9.72), and pancreatic (OR = 5.12, 95% CI = 2.43-10.78) cancers, were significantly overexpressed, and miR-19 was tightly related to some clinicopathological characteristics, such as lymph node metastasis (OR = 1.74, 95% CI = 1.05-2.86). +genetics_knock down_suppress 32964019 hsa-mir-185 Osteosarcoma 3p overexpression could reduce E2F1 levels in osteosarcoma cells. +circulation_biomarker_diagnosis_ns 32964011 hsa-mir-155 Breast Neoplasms This study was aimed at assessing serum miR-155 expression in patients with breast cancer and receptors. CONCLUSION: The findings of this study revealed that serum miR-155 may serve as a potential noninvasive molecular biomarker for breast cancer diagnosis and can help predict the grade of the disease. +transcription factor target 32963947 hsa-mir-155 Inflammation Herein, targeted codelivery of anti-miR 155 and anti-inflammatory baicalein is exploited to polarize macrophages toward M2 phenotype, inhibit inflammation and treat AS. +exosome 32963810 hsa-mir-185 Neoplasms, Glandular and Epithelial The extracellular level of EV-cargo miR5p is elevated in the setting of profound epithelial cell death. +transcription factor target 32963810 hsa-mir-185 Necrosis 5p regulates this process probably via suppressing FADD and caspase-8 which are both necroptosis inhibitors. +exosome 32963810 hsa-mir-185 Hyperoxia Importantly, extracellular vesicle (EV)-containing miR +circulation_biomarker_diagnosis_up 32963727 hsa-mir-29a Alzheimer Disease We investigated the association between circulating klotho and DPP4 activity and their relationship with inflammatory cytokines, miR-29a, and miR-195 in Alzheimer Disease (AD). +circulation_biomarker_diagnosis_up 32963727 hsa-mir-195 Alzheimer Disease We investigated the association between circulating klotho and DPP4 activity and their relationship with inflammatory cytokines, miR-29a, and miR-195 in Alzheimer Disease (AD). +transcription factor target 32963696 hsa-mir-10a Myocardial Reperfusion Injury More importantly, we found that DZ treatment can moderate ERS via regulation of the miR-10a/IRE1 pathway in the I/R and H/R models, thereby protecting myocardial H/R injury. +lncRNA target 32963621 hsa-mir-4485 Pneumonia, Aspiration In conclusion, miR-4485 inhibited H1N1-induced severe pneumonia in A549 cells by targeting STAT3 via the PI3K/AKT/mTOR signaling pathway. +other 32963619 hsa-mir-133b Laryngeal Neoplasms Joint detection of miR-203 and miR-133b is expected to be an excellent marker for the diagnosis and treatment of laryngeal carcinoma. +target gene 32963616 hsa-mir-150 Uterine Cervical Neoplasms MicroRNA-150 suppresses p27(Kip1) expression and promotes cell proliferation in HeLa human cervical cancer cells. +target gene 32963595 hsa-mir-210 Osteosarcoma circKMT2D contributes to H(2)O(2)-attenuated osteosarcoma progression via the miR-210/autophagy pathway. +other 32963586 hsa-mir-152 Osteosarcoma CONCLUSION: In summary, our study indicated that HAGLROS could promote osteosarcoma progression by sponging miR-152 to promote ROCK1 expression. The results showed HAGLROS/miR-152/ROCK1 axis might act as a novel therapeutic strategy for osteosarcoma. +lncRNA target 32963582 hsa-mir-370 Osteosarcoma In summary, this study shows that circITGA7 promotes OS proliferation and metastasis via miR-370/PIM1. +transcription factor target 32963317 hsa-mir-124 Retinal Diseases These results suggest that miR-124 could be a therapeutic target to alleviate fibrovascular proliferation in retinal diseases by regulating RPE proliferation/migration via RHOG. +lncRNA target 32963220 hsa-mir-196b Carcinoma, Non-Small-Cell Lung Our findings indicated that miR-196b-5p might exhibit novel oncogenic function by FAS-mediated STAT3 activation in NSCLC, and suggested that targeting the miR-196b-5p/FAS/NFkB/IL6/STAT3 pathway might be a promising therapeutic strategy in treating NSCLC. +transcription factor target 32963130 hsa-mir-21 Vascular Diseases Long-term caloric restriction and caloric restriction mimetics alleviated aging-related-fibrosis of kidney through downregulation of miR-21. +lncRNA target 32962742 hsa-mir-7 Glioma Thus, lncRNA LPP-AS2 promoted glioma tumorigenesis via a miR +other 32962636 hsa-mir-195 Endometrial Neoplasms The prognosis analysis revealed that Cyclin E1 (CCNE1, one of the 82 hub genes, which correlated with hsa-miR-195 and hsa-miR-424) was significantly linked to a worse overall survival in endometrial cancer patients. +other 32962510 hsa-mir-6769b Chemical and Drug Induced Liver Injury, Chronic These findings imply that regulating miR-6769b-5p or ATF4 expression in BMDMs may be helpful for treating chronic liver disease. +lncRNA target 32962500 hsa-mir-20a Nasopharyngeal Carcinoma MicroRNA-320a (miR-320a) was determined as a direct target for lncRNA ILF3-AS1 in nasopharyngeal carcinoma. +tissue_expression_ns 32961888 hsa-mir-133b Muscular Dystrophy, Duchenne In eight BMD patients, including two cases with evolving lower extremity weakness treated with deflazacort, we evaluated the expression level of 4 myo-miRNAs (miR-1, miR-206, miR-133a, and miR-133b), 3 inflammatory miRNAs (miR-146b, miR-155, and miR-221), FSTN, and GDF-8 proteins. +tissue_expression_ns 32961888 hsa-mir-206 Muscular Dystrophy, Duchenne In eight BMD patients, including two cases with evolving lower extremity weakness treated with deflazacort, we evaluated the expression level of 4 myo-miRNAs (miR-1, miR-206, miR-133a, and miR-133b), 3 inflammatory miRNAs (miR-146b, miR-155, and miR-221), FSTN, and GDF-8 proteins. +tissue_expression_ns 32961888 hsa-mir-221 Muscular Dystrophy, Duchenne In eight BMD patients, including two cases with evolving lower extremity weakness treated with deflazacort, we evaluated the expression level of 4 myo-miRNAs (miR-1, miR-206, miR-133a, and miR-133b), 3 inflammatory miRNAs (miR-146b, miR-155, and miR-221), FSTN, and GDF-8 proteins. +tissue_expression_ns 32961888 hsa-mir-155 Muscular Dystrophy, Duchenne In eight BMD patients, including two cases with evolving lower extremity weakness treated with deflazacort, we evaluated the expression level of 4 myo-miRNAs (miR-1, miR-206, miR-133a, and miR-133b), 3 inflammatory miRNAs (miR-146b, miR-155, and miR-221), FSTN, and GDF-8 proteins. +tissue_expression_ns 32961888 hsa-mir-133a Muscular Dystrophy, Duchenne In eight BMD patients, including two cases with evolving lower extremity weakness treated with deflazacort, we evaluated the expression level of 4 myo-miRNAs (miR-1, miR-206, miR-133a, and miR-133b), 3 inflammatory miRNAs (miR-146b, miR-155, and miR-221), FSTN, and GDF-8 proteins. +tissue_expression_ns 32961888 hsa-mir-146b Muscular Dystrophy, Duchenne In eight BMD patients, including two cases with evolving lower extremity weakness treated with deflazacort, we evaluated the expression level of 4 myo-miRNAs (miR-1, miR-206, miR-133a, and miR-133b), 3 inflammatory miRNAs (miR-146b, miR-155, and miR-221), FSTN, and GDF-8 proteins. +other 32961817 hsa-mir-145 Marfan Syndrome Moreover, twenty-five miRNAs, including miR-26a, miR-29, miR-143 and miR-145, were found to be downregulated and only miR-632 was upregulated in MFS TAA in vivo. +other 32961817 hsa-mir-632 Marfan Syndrome Moreover, twenty-five miRNAs, including miR-26a, miR-29, miR-143 and miR-145, were found to be downregulated and only miR-632 was upregulated in MFS TAA in vivo. +other 32961817 hsa-mir-143 Marfan Syndrome Moreover, twenty-five miRNAs, including miR-26a, miR-29, miR-143 and miR-145, were found to be downregulated and only miR-632 was upregulated in MFS TAA in vivo. +other 32961817 hsa-mir-26a Marfan Syndrome Moreover, twenty-five miRNAs, including miR-26a, miR-29, miR-143 and miR-145, were found to be downregulated and only miR-632 was upregulated in MFS TAA in vivo. +other 32961817 hsa-mir-29 Marfan Syndrome Moreover, twenty-five miRNAs, including miR-26a, miR-29, miR-143 and miR-145, were found to be downregulated and only miR-632 was upregulated in MFS TAA in vivo. +other 32961797 hsa-mir-103 Ovarian Neoplasms, High-Grade Serous We aimed to assess miRNA-103/107 expression levels in high grade serous ovarian cancer tissues. We assessed the relative expression of miRNA-103/107 (quantitative reverse transcription-polymerase chain reaction) in fifty archival formalin-fixed paraffin-embedded tissue samples of primary high grade serous ovarian cancer. +tissue_expression_up 32961797 hsa-mir-107 Ovarian Neoplasms, High-Grade Serous We also evaluated expression levels of miRNA-103/107 and DICER in selected ovarian cancer cell lines (A2780, A2780cis, SK-OV-3, OVCAR3). +other 32961661 hsa-mir-181b Cerebral Intraventricular Hemorrhage Levels of miR-223, miR-155, miR-181b, and miR-126 as well as Hb metabolites along with IL-8 were elevated in CSF after the onset of IVH vs. +other 32961661 hsa-mir-223 Cerebral Intraventricular Hemorrhage Levels of miR-223, miR-155, miR-181b, and miR-126 as well as Hb metabolites along with IL-8 were elevated in CSF after the onset of IVH vs. +other 32961661 hsa-mir-126 Cerebral Intraventricular Hemorrhage Levels of miR-223, miR-155, miR-181b, and miR-126 as well as Hb metabolites along with IL-8 were elevated in CSF after the onset of IVH vs. +other 32961661 hsa-mir-155 Cerebral Intraventricular Hemorrhage Levels of miR-223, miR-155, miR-181b, and miR-126 as well as Hb metabolites along with IL-8 were elevated in CSF after the onset of IVH vs. +other 32961635 hsa-mir-139 Liver Neoplasms 5p are significantly associated with liver cancer prognosis. +other 32961635 hsa-mir-500a Liver Neoplasms 5p are significantly associated with liver cancer prognosis. +other 32961635 hsa-mir-1266 Liver Neoplasms 5p are significantly associated with liver cancer prognosis. +other 32961635 hsa-mir-1180 Liver Neoplasms 5p are significantly associated with liver cancer prognosis. +other 32961635 hsa-mir-767 Liver Neoplasms 5p are significantly associated with liver cancer prognosis. +other 32961635 hsa-mir-105 Liver Neoplasms 5p are significantly associated with liver cancer prognosis. +other 32961635 hsa-mir-4746 Liver Neoplasms 5p are significantly associated with liver cancer prognosis. +lncRNA target 32961484 hsa-mir-30 Breast Neoplasms Based on these findings, TPT1-AS1 potentially represents a prognostic biomarker for patients with BC and participates in the development of BC through the TPT1-AS1/miR3p/QKI axis. +other 32961483 hsa-mir-944 Mouth Neoplasms CISH protein was significantly down-regulated in OSCC patients and cell lines and its level was inversely correlated with miR-944 expression. +genetics_knock down_suppress 32961441 hsa-mir-29a Aging, Premature Overexpression of miR-29a-3p and/or miR-30c-5p reduced ROS levels in DGCR8 knockdown hMSCs and rescued proliferation defects, mitochondrial dysfunction, and premature senescence. +circulation_biomarker_diagnosis_up 32961347 hsa-mir-150 Myasthenia Gravis Results showed that RTX decreased the serum exosomal miR +genetics_overexpression_promote 32961346 hsa-mir-195 Carcinoma, Hepatocellular 5p, and its overexpression reversed the suppression effect of miR +lncRNA target 32961145 hsa-mir-411 Multiple Myeloma 3p promotes the malignant proliferation and tumor stem cell like property of multiple myeloma through regulating HIF-1alpha. +transcription factor target 32961031 hsa-mir-429 Breast Neoplasms This study aimed to investigate the role of miR-429 in breast cancer progression. CONCLUSIONS: The results of our study suggest that miR-429 suppresses the proliferation and invasion of breast cancer via inhibiting the Wnt/beta-catenin signaling pathway. +circulation_biomarker_diagnosis_up 32960907 hsa-mir-193a Carcinoma, Hepatocellular Here, we evaluated serum levels of miR-193a-5p by qPCR in 41 HCC patients undergoing tumor resection (n = 33) or LT (n = 8) and 20 controls. +other 32960785 hsa-mir-425 Thyroid Cancer, Papillary These results demonstrate that AGAP2-AS1 expression is significantly elevated in PTC tissues and that, by binding to miRNA5p, it upregulates the MMP2 expression, thereby increasing the invasiveness and migration capacity of PTC cells. +other 32960511 hsa-mir-200c Endometriosis Circ_0007331 acted as a miRNA sponge for miR-200c-3p to indirectly regulate the function of HIF-1alpha, which plays a key role in the local angiogenesis and hypoxic mechanisms of ectopic endometrium. +other 32960473 hsa-mir-6501 COVID-19 Moreover, the expression of miR5p and miR-618 was 1.5-fold higher in the COVID-19 patients than in the healthy donors. +other 32960473 hsa-mir-618 COVID-19 Moreover, the expression of miR5p and miR-618 was 1.5-fold higher in the COVID-19 patients than in the healthy donors. +lncRNA target 32960438 hsa-mir-378c Adenocarcinoma of Lung In lung ADC cells, PVT1 negatively regulated miR-378c expression, and miR-378c negatively regulated SLC2A1 expression through binding to its 3'-untranslated coding regions. Together, silencing PVT1 downregulated SLC2A1 expression via targeting miR-378c, and then repressed lung ADC cells growth, migration, and invasion. +other 32960432 hsa-mir-665 Ischemic Stroke This was paralleled by elevation of miR-665 levels in monocytes collected from patients 24 h (p < 0.05 vs CT) and 48 h (p < 0.05 vs CT and p < 0.0001 vs 24 h) after ischemic stroke. +lncRNA target 32959905 hsa-mir-195 Hirschsprung Disease What is the main finding and its importance? Downregulation of AFAP1-AS1 blocks enteric neural crest stem cell proliferation, differentiation, migration and invasion and promotes the occurrence of HSCR via the miR-195/E2F3 axis, indicating thatAFAP1-AS might be a potential biomarker for HSCR patients. Altogether, AFAP1-AS1 silencing acts as an endogenous RNA by interacting with miR-195 to alter E2F3 expression, thus conferring repressive effects on ENCSC activity and promoting HSCR progression. +other 32959695 hsa-mir-32 Diabetic Nephropathies Our findings indicate that miR-32 may play roles in the progression of EMT and fibrosis in DN. +other 32959231 hsa-mir-34c Stomach Neoplasms CONCLUSION: In conclusion, HCMV-induced miR-34c or miR-138 involves in the activation of IL6/STAT3 signaling. +other 32959231 hsa-mir-138 Stomach Neoplasms CONCLUSION: In conclusion, HCMV-induced miR-34c or miR-138 involves in the activation of IL6/STAT3 signaling. +other 32959231 hsa-mir-34 Stomach Neoplasms CONCLUSION: In conclusion, HCMV-induced miR-34c or miR-138 involves in the activation of IL6/STAT3 signaling. +genetics_knock down_promote 32958647 hsa-mir-128 Fragile X Syndrome 3p in FMRP-deficient astroglia sufficiently rescues decreased mGluR5 function, while astroglial overexpression of miR +other 32958526 hsa-mir-223 Inflammation This suggests the potential contribution of miR-223 to the resolution phase of GBS-induced acute inflammation. +transcription factor target 32958526 hsa-mir-223 Guillain-Barre Syndrome Transient inhibition of miR-223 by an antagomir resulted in significant increase of CXCL2 expression and partial enhancement of infiltrating neutrophils in GBS-infected lung tissues. +other 32958526 hsa-mir-223 Pneumonia In this study, we analyzed the kinetic expression of miR-223 in an inflammatory model of GBS-induced murine pneumonia and looked for correlates with inflammatory markers, including innate cell infiltrates. +other 32958526 hsa-mir-223 Bacterial Infections Yet the dynamic pattern of expression of miR-223 in vivo with respect to the evolution of the inflammatory process, especially in microbial infection, remains elusive. +lncRNA target 32958516 hsa-mir-146a Cardiomyopathies Extracellular miR-146a-5p Induces Cardiac Innate Immune Response and Cardiomyocyte Dysfunction. Taken together, these data demonstrate that extracellular miR-146a-5p activates multiple cardiac cells and induces myocardial inflammation and cardiomyocyte dysfunction via intercellular interaction and innate immune TLR7 nucleic acid sensing. +genetics_overexpression_promote 32958011 hsa-mir-141 Small Cell Lung Carcinoma overexpressing SCLC cells had a higher microvessel density (MVD) and grew faster than those developed from negative control cells. +lncRNA target 32957587 hsa-mir-375 Neuroendocrine Tumors Through high expression analyses, we found that miR-21 and -375 are abundant in all lung NENs, and that miR-21/miR-375 expression ratios are significantly lower in carcinoids (TC and AC) than in neuroendocrine carcinomas (NECs; SCLC and LCNEC). +lncRNA target 32957587 hsa-mir-21 Neuroendocrine Tumors Through high expression analyses, we found that miR-21 and -375 are abundant in all lung NENs, and that miR-21/miR-375 expression ratios are significantly lower in carcinoids (TC and AC) than in neuroendocrine carcinomas (NECs; SCLC and LCNEC). +other 32957587 hsa-mir-17 Neuroendocrine Tumors We also identified miR-17, -103, and -127, and miR-301a, -106b, and -25, as candidate markers for discriminating TC from AC, and SCLC from LCNEC, respectively. +other 32957376 hsa-mir-1 Pancreatic Carcinoma Finally, AUC was used to evaluate the performance of miRNAs to classify PC and control samples.A total of 33 differentially expressed miRNAs, 753 differentially expressed genes, and 8 miRNAs (hsa-mir-139, hsa-mir-31, hsa-mir-196b, hsa-mir-221, hsa-mir-203b, hsa-mir-215, hsa-mir-144, and hsa-mir-4433b) that play important roles in PC were identified. +other 32957376 hsa-mir-144 Pancreatic Carcinoma Finally, AUC was used to evaluate the performance of miRNAs to classify PC and control samples.A total of 33 differentially expressed miRNAs, 753 differentially expressed genes, and 8 miRNAs (hsa-mir-139, hsa-mir-31, hsa-mir-196b, hsa-mir-221, hsa-mir-203b, hsa-mir-215, hsa-mir-144, and hsa-mir-4433b) that play important roles in PC were identified. +other 32957376 hsa-mir-4433b Pancreatic Carcinoma Finally, AUC was used to evaluate the performance of miRNAs to classify PC and control samples.A total of 33 differentially expressed miRNAs, 753 differentially expressed genes, and 8 miRNAs (hsa-mir-139, hsa-mir-31, hsa-mir-196b, hsa-mir-221, hsa-mir-203b, hsa-mir-215, hsa-mir-144, and hsa-mir-4433b) that play important roles in PC were identified. +other 32957376 hsa-mir-221 Pancreatic Carcinoma Finally, AUC was used to evaluate the performance of miRNAs to classify PC and control samples.A total of 33 differentially expressed miRNAs, 753 differentially expressed genes, and 8 miRNAs (hsa-mir-139, hsa-mir-31, hsa-mir-196b, hsa-mir-221, hsa-mir-203b, hsa-mir-215, hsa-mir-144, and hsa-mir-4433b) that play important roles in PC were identified. +other 32957376 hsa-mir-196b Pancreatic Carcinoma Finally, AUC was used to evaluate the performance of miRNAs to classify PC and control samples.A total of 33 differentially expressed miRNAs, 753 differentially expressed genes, and 8 miRNAs (hsa-mir-139, hsa-mir-31, hsa-mir-196b, hsa-mir-221, hsa-mir-203b, hsa-mir-215, hsa-mir-144, and hsa-mir-4433b) that play important roles in PC were identified. +other 32957376 hsa-mir-215 Pancreatic Carcinoma Finally, AUC was used to evaluate the performance of miRNAs to classify PC and control samples.A total of 33 differentially expressed miRNAs, 753 differentially expressed genes, and 8 miRNAs (hsa-mir-139, hsa-mir-31, hsa-mir-196b, hsa-mir-221, hsa-mir-203b, hsa-mir-215, hsa-mir-144, and hsa-mir-4433b) that play important roles in PC were identified. +other 32957376 hsa-mir-139 Pancreatic Carcinoma Finally, AUC was used to evaluate the performance of miRNAs to classify PC and control samples.A total of 33 differentially expressed miRNAs, 753 differentially expressed genes, and 8 miRNAs (hsa-mir-139, hsa-mir-31, hsa-mir-196b, hsa-mir-221, hsa-mir-203b, hsa-mir-215, hsa-mir-144, and hsa-mir-4433b) that play important roles in PC were identified. +exosome 32956770 hsa-mir-23b Intracranial Aneurysm All in all, our study concluded that BMSCs-derived exosomal hsa-miR-23b-3p could maintain Th17/Treg balance by targeting KLF5 through suppression of the PI3k/Akt/NF-kappaB signaling pathway, thus inhibit IA formation. +transcription factor target 32956705 hsa-mir-3074 Pituitary Diseases 5p target gene in these cells, thus at least in part serving as a functional mediator of the lncEif4g2/miR +genetics_overexpression_promote 32956704 hsa-mir-7 Squamous Cell Carcinoma of Head and Neck Further experiments demonstrated that ciRS-7 overexpression could attenuate the anti-tumor effects of miR-7 on OSCC cells. +transcription factor target 32956666 hsa-mir-191 Obesity 5p may serve as a potential target for the identification and treatment of obesity. +lncRNA target 32956593 hsa-mir-7855 Carcinoma, Hepatocellular In addition, our results revealed that AC006262.5 bound to and regulated miR5p, a tumor-suppressive miRNA, in HCC. +genetics_knock down_promote 32955920 hsa-mir-497 Breast Neoplasms Conclusion: AFAP1-AS1 knockdown repressed the progression of breast cancer cells by sponging miR +other 32955900 hsa-mir-96 Hyperemia CONCLUSION: In spite of the multiple limitations of the study, it can be considered that the increased expression of platelet miR-96 found in a group of patients with SPS and pregnancy complications could be related to the hyperaggregability in these selected patients (Tab. +other 32955900 hsa-mir-126 Blood Platelet Disorders AIMS: We aimed to characterize relationship between the expression profiles of platelet miR-96, miR-126 and miR-223 and platelet function examination in patients with sticky platelet syndrome (SPS) and in healthy controls. +other 32955900 hsa-mir-96 Blood Platelet Disorders CONCLUSION: In spite of the multiple limitations of the study, it can be considered that the increased expression of platelet miR-96 found in a group of patients with SPS and pregnancy complications could be related to the hyperaggregability in these selected patients (Tab. +other 32955900 hsa-mir-223 Hyperemia AIMS: We aimed to characterize relationship between the expression profiles of platelet miR-96, miR-126 and miR-223 and platelet function examination in patients with sticky platelet syndrome (SPS) and in healthy controls. +other 32955900 hsa-mir-223 Blood Platelet Disorders AIMS: We aimed to characterize relationship between the expression profiles of platelet miR-96, miR-126 and miR-223 and platelet function examination in patients with sticky platelet syndrome (SPS) and in healthy controls. +other 32955900 hsa-mir-126 Hyperemia AIMS: We aimed to characterize relationship between the expression profiles of platelet miR-96, miR-126 and miR-223 and platelet function examination in patients with sticky platelet syndrome (SPS) and in healthy controls. +circRNA target 32954926 hsa-mir-338 Osteosarcoma Circ_0001649 suppressed OS cell proliferation and STAT pathway and induced apoptosis through sponging miR5p, miR-647 and miR-942. +circRNA target 32954926 hsa-mir-647 Osteosarcoma Circ_0001649 suppressed OS cell proliferation and STAT pathway and induced apoptosis through sponging miR5p, miR-647 and miR-942. +circRNA target 32954926 hsa-mir-942 Osteosarcoma Circ_0001649 suppressed OS cell proliferation and STAT pathway and induced apoptosis through sponging miR5p, miR-647 and miR-942. +other 32954867 hsa-mir-146a Digestive System Neoplasms MiR-146a rs2910164 locus was also identified to be correlated with a risk of DSC in Asians (GG/CG vs. +genetics_GWAS 32954360 hsa-mir-16-1 Multiple Myeloma Taking advantage of this model, we explored the role in MM initiation and progression of two candidate loci on chromosome 13: RB1 and MIR15A/MIR16-1. +genetics_GWAS 32954360 hsa-mir-15a Multiple Myeloma Taking advantage of this model, we explored the role in MM initiation and progression of two candidate loci on chromosome 13: RB1 and MIR15A/MIR16-1. +other 32954174 hsa-mir-218 Stomach Neoplasms 5p mimics could reverse the tumor-promoting roles of circRIMS in GC. +other 32954174 hsa-mir-148a Stomach Neoplasms 5p mimics could reverse the tumor-promoting roles of circRIMS in GC. +circulation_biomarker_diagnosis_ns 32954093 hsa-mir-216a Obesity Interestingly, this was associated with a negative correlation between the plasma miR-216a content and body mass index (BMI), waist circumference, mean arterial pressure (MAP), triglycerides, ratio of total cholesterol/high density lipoprotein (HDL)-cholesterol and high sensitivity-C reactive protein (hs-CRP).Taken together, we provide evidence for an abnormally expressed circulating miRNA, miR-216a, with additive value as a predictive marker for obesity that correlates with metabolic alterations presented by lipid profile and inflammatory markers. +genetics_overexpression_promote 32953981 hsa-mir-382 Carcinoma, Hepatocellular In conclusion, overexpression of miR-382 promotes HCC cell lysis induced by gammadelta T cells through inhibiting the expression of c-FLIP. +lncRNA target 32953888 hsa-mir-129 Osteosarcoma Collectively, it suggests that downregulation of KCNQ1OT1 inhibits proliferation, invasion, and drug resistance by regulating miR +other 32953883 hsa-mir-101 Myocardial Infarction CONCLUSION: MiR-101 can promote angiogenesis in the region surrounding the myocardial infarction. +other 32953807 hsa-mir-429 Esophageal Squamous Cell Carcinoma Quantitative real-time PCR (qRT-PCR) assay was implemented in ESCC cells for detecting the expression of lncRNA, SNHG22, and miR-429. CONCLUSIONS: SNHG22 promotes the progression of ESCC by the miR-429/SESN3 axis. +circulation_biomarker_diagnosis_ns 32953805 hsa-mir-183 Cerebral Small Vessel Diseases A correlation analysis of serum miRNA-183 level and imaging lesion characteristics in patients with CSVD was also conducted. +circulation_biomarker_diagnosis_ns 32953805 hsa-mir-183 Reperfusion Injury, Cerebral Ischemia A correlation analysis of serum miRNA-183 level and imaging lesion characteristics in patients with CSVD was also conducted. +other 32953799 hsa-mir-203 Esophageal Neoplasms CircRNA-0008717 promotes cell proliferation, migration, and invasion by regulating miR-203/Slug in esophageal cancer cells. +circulation_biomarker_diagnosis_up 32953796 hsa-mir-134 Obsessive-Compulsive Disorder Therefore, miRNA-132 and miRNA-134 plasma levels should be considered as potential biomarkers for OCD detection. +circulation_biomarker_diagnosis_up 32953796 hsa-mir-132 Obsessive-Compulsive Disorder Therefore, miRNA-132 and miRNA-134 plasma levels should be considered as potential biomarkers for OCD detection. +target gene 32953795 hsa-mir-182 Triple Negative Breast Neoplasms Downregulation of miR-182-5p inhibits the proliferation and invasion of triple-negative breast cancer cells through regulating TLR4/NF-κB pathway activity by targeting FBXW7. +other 32953502 hsa-mir-663 Pleural Effusion, Malignant A combination of hsa-miR-4484 and hsa-miR3p showed potential discriminatory power for MPE detection, and it may be helpful for the early diagnosis of MPE, i.e., before the pleural effusion volume is too large. +other 32953502 hsa-mir-4484 Pleural Effusion, Malignant A combination of hsa-miR-4484 and hsa-miR3p showed potential discriminatory power for MPE detection, and it may be helpful for the early diagnosis of MPE, i.e., before the pleural effusion volume is too large. +lncRNA target 32953492 hsa-mir-150 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: our study highlights that LINC00511 facilitates LUSC progression via sequestering miR +other 32953406 hsa-mir-143 ankylosing spondylitis 1 According to current knowledge, miR5p andmiR-143 expressions were found to be important for those diseases that share similar etiology with AS. +other 32953406 hsa-mir-142 ankylosing spondylitis 1 According to current knowledge, miR5p andmiR-143 expressions were found to be important for those diseases that share similar etiology with AS. +other 32952670 hsa-let-7 Breast Neoplasms In this study, let-7 miRNA and CDK4-specific siRNA were chosen as therapeutic agents and co-encapsulated in Herceptin-conjugated cationic liposomes for breast cancer therapy. +circulation_biomarker_prognosis_ns 32952660 hsa-mir-365 Carcinoma, Non-Small-Cell Lung In conclusion, the expression levels of miR-25 and miR-365 were different in the serum of NSCLC patients, and they were closely related to certain clinical characteristics such as peripheral infiltration, pathological grade, tumor diameter, TNM stage and lymph node metastasis. +lncRNA target 32952657 hsa-mir-34a Breast Neoplasms The results of the present study suggested that lnc-ANGPTL1-3:3 and lnc-GJA10-12:1 may potentially serve a role in SLN metastasis of breast cancer by regulating the PI3K/Akt and MAPK signaling pathways via targeting the miR-302 family, miR-520a-3p, miR-34a-5p and miR-449a. +lncRNA target 32952657 hsa-mir-520a Breast Neoplasms The results of the present study suggested that lnc-ANGPTL1-3:3 and lnc-GJA10-12:1 may potentially serve a role in SLN metastasis of breast cancer by regulating the PI3K/Akt and MAPK signaling pathways via targeting the miR-302 family, miR-520a-3p, miR-34a-5p and miR-449a. +lncRNA target 32952657 hsa-mir-449a Breast Neoplasms The results of the present study suggested that lnc-ANGPTL1-3:3 and lnc-GJA10-12:1 may potentially serve a role in SLN metastasis of breast cancer by regulating the PI3K/Akt and MAPK signaling pathways via targeting the miR-302 family, miR-520a-3p, miR-34a-5p and miR-449a. +transcription factor target 32952653 hsa-mir-27b Burns The results of the in vivo experiments demonstrated that miR-27b inhibition accelerated scalded skin healing and induced fibroblast growth. In conclusion, the results of the present study revealed that miR-27b inhibition increased fibroblast proliferation, thereby accelerating scald wound healing in rats. +target gene 32952645 hsa-mir-590 Colorectal Neoplasms miR-590-5p may regulate colorectal cancer cell viability and migration by targeting PDCD4. +genetics_knock down_promote 32952643 hsa-mir-23a Pancreatic Carcinoma Furthermore, TFPI-2 knockdown rescued the biological effects on PC cells, which were induced by miR-23a knockdown. +genetics_overexpression_suppress 32952629 hsa-mir-146a Graves Ophthalmopathy Overexpression of miR-146a reduced, and inhibition of miR-146a increased the production of HA and collagen I in GO orbital fibroblasts. +transcription factor target 32952601 hsa-mir-152 Colonic Neoplasms 3p can affect the pathogenesis of colon cancer via the KLF4/IFITM3 axis. +lncRNA target 32952069 hsa-mir-769 Stomach Neoplasms Taken together, our study showed that HAND2-AS1 exerts its tumor suppressive role in GC via regulating miR +transcription factor target 32951990 hsa-mir-27a Carcinoma, Squamous Cell, Cutaneous The function of APE1 and miR-27a in cSCC cells was investigated by cell counting kit-8 (CCK-8) assays, colony formation assays and transwell migration assays. CONCLUSION: As a direct gene of miR-27a, APE1 improved cell proliferation and migration to promote the progression of cSCC, which could be considered as a potential therapeutic target for cSCC treatment. +genetics_overexpression_suppress 32951513 hsa-mir-144 Thyroid Carcinoma, Anaplastic miR-144 overexpression reversed the oncogenic roles of HOTAIRM1 in ATC. +lncRNA target 32951449 hsa-mir-1258 Breast Neoplasms Hsa_circ_002178 was further proved to downregulate the level of miR-1258 and reduce the inhibitory effect of miR-1258 on KDM7A, thus regulating the stem-like characteristics of BrCa cells and promoting the growth and migration of BrCa cells. Taken together, targeting the circ_002178/miR-1258/KDM7A axis may be a prospective strategy for the diagnosis and therapies of BrCa in the future. +genetics_knock down_promote 32951268 hsa-mir-182 Carcinoma, Hepatocellular 5p overexpression clearly reversed EMT and promoted SOR-induced cytotoxicity in representative HCC cells, whereas miR +target gene 32950974 hsa-mir-132 Enterocolitis Lipopolysaccharide upregulates miR-132/212 in Hirschsprung-associated enterocolitis, facilitating pyroptosis by activating NLRP3 inflammasome via targeting Sirtuin 1 (SIRT1). +target gene 32950974 hsa-mir-212 Enterocolitis Lipopolysaccharide upregulates miR-132/212 in Hirschsprung-associated enterocolitis, facilitating pyroptosis by activating NLRP3 inflammasome via targeting Sirtuin 1 (SIRT1). +genetics_overexpression_promote 32950808 hsa-mir-126 Uterine Cervical Neoplasms CONCLUSION: These results provide the evidence that LINC00673 overexpression promotes cervical cancer cells progression through regulating miR +circulation_biomarker_diagnosis_ns 32950706 hsa-mir-19b Schizophrenia To elucidate them, first we examined the levels of miR-19a and 19b in peripheral blood of SZ patients with quantitative RT-PCR and showed that the level of miR-19b, but not miR-19a, was significantly higher (miR-19a: p = 0.5733, miR-19b: p = 0.0038) in peripheral blood of SZ patients (N = 22) than that of healthy controls (N = 19). These results suggest that the level of miR-19b in peripheral blood is a potential biomarker of schizophrenia and that the higher level of miR-19b may increase the vulnerability of SZ via attenuating proliferation of hippocampal NPC. +other 32950591 hsa-mir-614 Coronary Artery Disease RESULTS: The decreased expression of miR-3614 was identified in CAD EAT. +lncRNA target 32950571 hsa-mir-98 Breast Neoplasms Through analyzing the effects of hub genes on overall survival of BC patients and their expression correlation with miRNAs, we found hsa-miR5p/IGF1 axis may play a crucial role in BC progression. +genetics_knock down_promote 32950535 hsa-mir-26a Cataract RESULTS: KCNQ1OT1 was up-regulated and miR-26a-5p level was reduced in diabetic cataract tissues and HG-treated SRA01/04 cells. CONCLUSION: KCNQ1OT1 knockdown represses cell viability, migration and EMT through miR-26a-5p/ITGAV/TGF-beta/Smad3 axis in SRA01/04 cells under HG condition, providing a new target for the treatment of diabetic cataract. +other 32950495 hsa-mir-210 Diabetic Nephropathies MiR-(210 & 34a) were markedly up-regulated in DN groups (micro-albuminuric and macro-albuminuric groups) compared to the non-albuminuric group and healthy controls. +genetics_knock down_suppress 32950487 hsa-mir-34c Carcinoma, Non-Small-Cell Lung Our study highlights that decreased miR-34c-5p in drug-resistant epilepsy exacerbates neuroinflammation, which aggravates hippocampal neuron loss in epileptogenesis. +other 32950473 hsa-mir-200a Diabetic Nephropathies Overall, IRE1alpha upregulates miR-200a degradation in DN rats, and stimulates the TXINP/NLRP3 pathway-mediated pyroptosis and renal damage. +genetics_overexpression_suppress 32950103 hsa-mir-204 Memory Disorders 3p overexpression and/or Nox4 inhibition might be a potential therapeutic strategy for AD treatment. +genetics_overexpression_suppress 32950103 hsa-mir-204 Alzheimer Disease 3p overexpression and/or Nox4 inhibition might be a potential therapeutic strategy for AD treatment. +circulation_biomarker_diagnosis_ns 32950048 hsa-mir-21 Breast Neoplasms Early detection breast cancer: role of circulating plasma miRNA-21 expression as a potential screening biomarker Aim To explore the potential of the circulating plasma miRNA-21 as an early detection biomarker by comparing early-stage breast cancer (BG) and healthy control (HG) in Indonesian population. Conclusions Circulating miRNA-21 expression is a potential biomarker for early detection of breast cancer and might act as a breast cancer risk predictor. +genetics_overexpression_suppress 32949706 hsa-mir-1248 Lung Neoplasms Importantly, the inhibitory effect of C3A or the promoting effect of miR-1248 on LUSC cells growth, invasion and migration abilities can be regulated by STARD13-AS. CONCLUSIONS: Our findings revealed that overexpression of STARD13-AS restricted the growth and aggressiveness of LUSC cells via regulating miR-1248/C3A. +other 32949564 hsa-mir-20a Chronic Disease Thus, miR-19a/b and miR-20a being crucial regulators of wound inflammation, the lack thereof may contribute to sustained inflammation and impaired healing in chronic wounds. +other 32949564 hsa-mir-18a Wounds and Injuries In this study, we show that in human wound-edge keratinocytes, the expressions of microRNA (miR)-17, miR-18a, miR-19a, miR-19b, and miR-20a, which all belong to the miR-17 approximately 92 cluster, are upregulated during wound repair. +other 32949564 hsa-mir-17 Wounds and Injuries In this study, we show that in human wound-edge keratinocytes, the expressions of microRNA (miR)-17, miR-18a, miR-19a, miR-19b, and miR-20a, which all belong to the miR-17 approximately 92 cluster, are upregulated during wound repair. +other 32949564 hsa-mir-19a Chronic Disease Thus, miR-19a/b and miR-20a being crucial regulators of wound inflammation, the lack thereof may contribute to sustained inflammation and impaired healing in chronic wounds. +transcription factor target 32949431 hsa-mir-350 Liver Cirrhosis Taken together, we demonstrated that ASIC1a regulates the processing of miR-350 through METTL3-dependent m(6) A modification, and mature miR-350 targets SPRY2 and further promotes liver fibrosis through the PI3K/KT and ERK pathways. +other 32949355 hsa-mir-146a Crohn Disease Among the eight miRNAs, the amounts of miR-146a and miR-21 were significantly decreased in the CD patients relative to HC subjects. Under-expression of miR-146a and miR-21, which are critical for the regulatory function of regulatory T cells (Tregs), is remarkably associated with CD. +other 32949355 hsa-mir-21 Crohn Disease Among the eight miRNAs, the amounts of miR-146a and miR-21 were significantly decreased in the CD patients relative to HC subjects. Under-expression of miR-146a and miR-21, which are critical for the regulatory function of regulatory T cells (Tregs), is remarkably associated with CD. +genetics_GWAS 32948832 hsa-mir-34c Carcinoma, Non-Small-Cell Lung Altogether, our findings demonstrate that miR-34c-3p is a novel biomarker that may allow tailored treatment for KRAS-mutated NSCLC patients. +genetics_overexpression_promote 32948745 hsa-mir-199a Squamous Cell Carcinoma of Head and Neck In vitro rescue assays demonstrated that miR-199a-5p inhibitor or FZD4 overexpression reversed the effects of LINC00319 silencing in OSCC. +lncRNA target 32948650 hsa-mir-99b Liver Neoplasms The expression of miR-99b and its target genes was determined in TAMs sorted from tumor and adjacent tissues in patients with liver cancer. Finally, miR-99b expression was lower in TAMs of patients with liver cancer than that in adjacent tissues, while the expression of kappaB-Ras2 and mTOR was reversed. +genetics_knock down_promote 32948241 hsa-mir-1271 Ovarian Neoplasms 5p knockdown promoted the proliferation of OC cells. +lncRNA target 32948213 hsa-mir-29a Spinal Cord Injuries This study aims to research the functions of miR-29a/199B in the neurological function recovery after SCI and the mechanical mechanism. CONCLUSION: This study evidenced that miR-29a and miR-199B negatively regulated RGMA to suppress STAT3 phosphorylation, therefore promoting the neurological function recovery in rats following SCI. +lncRNA target 32948213 hsa-mir-199b Spinal Cord Injuries This study aims to research the functions of miR-29a/199B in the neurological function recovery after SCI and the mechanical mechanism. CONCLUSION: This study evidenced that miR-29a and miR-199B negatively regulated RGMA to suppress STAT3 phosphorylation, therefore promoting the neurological function recovery in rats following SCI. +lncRNA target 32948197 hsa-mir-149 Adenocarcinoma of Lung 5p-SYNE3 transcriptional network in lung adenocarcinoma to support the tumor-suppressing role of SYNE3. +circulation_biomarker_diagnosis_up 32947508 hsa-mir-183 Atherosclerosis Serum miR +other 32947363 hsa-mir-221 Adenocarcinoma of Lung Meanwhile, the expression level of miR3p was much higher in LA tumor samples than that in the adjacent normal tissues (19 LA vs. +genetics_GWAS 32947363 hsa-mir-10b Adenocarcinoma of Lung 5p, and miR-10b-5p was significantly elevated in LA patients with epidermal growth factor receptor mutation compared with NCs. +other 32947244 hsa-mir-482bd Dehydration Polyethylene glycol experiment was used to simulate drought stress, and miR482bd-5p, HEC1, and BAK1 presented a similar expression pattern, as found in salt stress. +genetics_knock down_promote 32946972 hsa-mir-148b Breast Neoplasms In conclusion, LINC00346 knockdown suppressed breast cancer cell glycolysis by upregulating miR-148a/b and repressing GLUT1 expression. +genetics_knock down_promote 32946972 hsa-mir-148a Breast Neoplasms In conclusion, LINC00346 knockdown suppressed breast cancer cell glycolysis by upregulating miR-148a/b and repressing GLUT1 expression. +lncRNA target 32946964 hsa-let-7a Triple Negative Breast Neoplasms Taken together, our results indicate that the let-7a-5p/GLUT12 axis plays key roles in TNBC tumor growth and metastasis, and aerobic glycolysis, and is a potential target for TNBC treatment. +lncRNA target 32946927 hsa-mir-93 Pituitary Neoplasms ATG7 axis in DA treatment of prolactinomas, which may be a potential therapeutic target for human prolactinomas. +lncRNA target 32946927 hsa-mir-93a Pituitary Neoplasms Mechanistically, H19 promoted ATG7 expression in pituitary tumor cells by inhibiting miR-93a expression. +lncRNA target 32946211 hsa-mir-155 Parkinson Disease In conclusion, RA was able to alleviate PD by regulating miR +circulation_biomarker_diagnosis_up 32945523 hsa-mir-3133 Budd-Chiari Syndrome A previous study by our group suggested that miR3133 was downregulated in the serum of patients with MOVC. +lncRNA target 32945523 hsa-mir-3133 Respiratory Paralysis In conclusion, the present study demonstrated that miR3133 regulated endothelial cell proliferation and angiogenesis through the JUNB/VEGF pathway, which may provide an approach for inhibiting diaphragm formation of the inferior vena cava in MOVC. +lncRNA target 32945522 hsa-mir-627 Lung Neoplasms Mechanistically, it was demonstrated that RP11284F21.9 promoted the proliferation and invasiveness of lung carcinoma cells, in part, via the regulation of miR6273p. +genetics_knock down_promote 32945521 hsa-mir-195 Stomach Neoplasms These results could be reversed by ETS1 upregulation or miR1955pknockdown in GC cells. +lncRNA target 32945505 hsa-mir-4500 Ovarian Neoplasms miR4500 expression levels were low, whereas NEAT1 expression levels were high in OC tissues and cell lines compared with control tissues and cell lines. Collectively, the present study suggested that NEAT1 modulated cell proliferation, colony formation, apoptosis, migration, invasion and glycolysis via the miR4500/BZW1 axis in OC; therefore, NEAT1 may serve as a therapeutic target for OC. +genetics_overexpression_promote 32945499 hsa-mir-188 Breast Neoplasms We demonstrated that the overexpression of miR1885p significantly inhibited the expression of ZFP91 in BC cell lines and reduced the expression of NFkappaB p65(Rel). +lncRNA target 32945498 hsa-mir-150 Squamous Cell Carcinoma of Head and Neck We uncovered a previously unappreciated PVT1/miR1505p/GLUT1 signaling axis that promotes cell proliferation, invasion, migration and inhibits apoptosis in OSCC cell lines and in vivo, which suggests that this axis could be a target for the treatment of OSCC. +genetics_knock down_suppress 32945481 hsa-mir-409 Carcinoma, Non-Small-Cell Lung Notably, rescue experiments revealed that the inhibition of miR4093p or restoration of SPIN1 expression abrogated the effects of PSMA3AS1 knockdown in NSCLC cells. +genetics_knock down_promote 32945478 hsa-mir-590 Esophageal Squamous Cell Carcinoma Furthermore, it was found that miR590 overexpression and LRP6 knockdown inhibited cell migration, invasion and epithelialtomesenchymal transition (EMT) in ESCC cell lines. +lncRNA target 32945477 hsa-mir-376a Endometrial Neoplasms With respect to the mechanisms, miR376a3p was revealed to be targeted by TTNAS1, and reversed the effects on EC development induced by TTNAS1. Collectively, TTNAS1 enhanced EC cell proliferation and metastasis by targeting the miR376a3p/PUM2 axis, which may shed light on EC diagnosis and treatment. +lncRNA target 32945474 hsa-mir-619 Colorectal Neoplasms The results revealed that the expression of LINC00958 was notably upregulated, whereas miR36195p was downregulated in CRC cells. Taken together, the findings suggest that the downregulation of LINC00958 suppresses the proliferation, invasion and migration, and promotes the apoptosis of CRC cells by targeting miR36195p in vitro, which provides a theoretical basis and therapeutic strategy for the treatment of CRC. +lncRNA target 32945470 hsa-mir-33a Hemangioma, Cavernous Collectively, the results revealed that depletion of lncRNA NEAT1 suppressed the tumorigenesis of IH by competitively binding miR33a5p and thereby stimulating the HIF1alpha/NFkappaB signaling pathway. +lncRNA target 32945466 hsa-mir-509 Carcinoma, Non-Small-Cell Lung Collectively, the results of the present study indicate that the CBR3AS1/miR5093p/HDAC9 pathway exerts tumorpromoting actions in NSCLC oncogenesis and progression, suggesting that this pathway is an effective target for the management of NSCLC. +lncRNA target 32945459 hsa-mir-485 Osteosarcoma Finally, it was revealed that silencing of NR2F1AS1 repressed the OS cell malignant phenotype by binding with miR4855p and miR2185p, and then downregulating BIRC5 expression, which suggests that the NR2F1AS1/miR4855p/miR2185p/BIRC5 axis could be a potential target for treating OS. +lncRNA target 32945459 hsa-mir-218 Osteosarcoma Finally, it was revealed that silencing of NR2F1AS1 repressed the OS cell malignant phenotype by binding with miR4855p and miR2185p, and then downregulating BIRC5 expression, which suggests that the NR2F1AS1/miR4855p/miR2185p/BIRC5 axis could be a potential target for treating OS. +lncRNA target 32945458 hsa-mir-15b Thyroid Neoplasms Thus, the results indicated a potential tumor suppressive role of miR15b5p in THCA, which was mainly exerted by targeting GDI2 and modulating MMP2 and MMP9. +other 32945452 hsa-mir-4654 Cicatrix, Hypertrophic Notably, microRNA-4654 (miR-4654) was significantly decreased in the HSFBs and re-upregulated by resveratrol treatment dose-dependently. +genetics_knock down_promote 32945445 hsa-mir-19a Ischemic Stroke An AISrelated ceRNA network was constructed, in which 4 DELs were predicted to function as ceRNAs for 9 DEMs, to regulate the five identified hub genes; that is, minichromosome maintenance complex component 3 associated proteinantisense RNA 1 (MCM3APAS1)/long intergenic nonprotein coding RNA 1089 (LINC01089)/hsamiRNA (miR)125a/FYN, inositoltetrakisphosphate 1kinaseantisense RNA 1 (ITPK1AS1)/hsalet7i/RHOA/GRB2/STAT1, and human leukocyte antigen complex group 27 (HCG27)/hsa-miR19a/PXN interaction axes. +genetics_knock down_promote 32945445 hsa-let-7i Ischemic Stroke An AISrelated ceRNA network was constructed, in which 4 DELs were predicted to function as ceRNAs for 9 DEMs, to regulate the five identified hub genes; that is, minichromosome maintenance complex component 3 associated proteinantisense RNA 1 (MCM3APAS1)/long intergenic nonprotein coding RNA 1089 (LINC01089)/hsamiRNA (miR)125a/FYN, inositoltetrakisphosphate 1kinaseantisense RNA 1 (ITPK1AS1)/hsalet7i/RHOA/GRB2/STAT1, and human leukocyte antigen complex group 27 (HCG27)/hsa-miR19a/PXN interaction axes. +genetics_knock down_promote 32945445 hsa-mir-125a Ischemic Stroke An AISrelated ceRNA network was constructed, in which 4 DELs were predicted to function as ceRNAs for 9 DEMs, to regulate the five identified hub genes; that is, minichromosome maintenance complex component 3 associated proteinantisense RNA 1 (MCM3APAS1)/long intergenic nonprotein coding RNA 1089 (LINC01089)/hsamiRNA (miR)125a/FYN, inositoltetrakisphosphate 1kinaseantisense RNA 1 (ITPK1AS1)/hsalet7i/RHOA/GRB2/STAT1, and human leukocyte antigen complex group 27 (HCG27)/hsa-miR19a/PXN interaction axes. +genetics_knock down_suppress 32945443 hsa-mir-1321 Ovarian Neoplasms Knockdown of NEAT1 attenuated the migration and invasion of OC cells, as well as increased miR1321 expression and in turn led to the reduction of TJP3. Thus, the present study demonstrated that NEAT1 regulates TJP3 expression by sponging miR1321 and enhances the epithelialmesenchymal transition, invasion and migration of OC cells. +genetics_knock down_promote 32945436 hsa-mir-143 Colorectal Neoplasms TMPOAS1 knockdown and miR1433p overexpression significantly inhibited cell proliferation, migration and invasion of CRC cells. +lncRNA target 32945425 hsa-mir-204 Stomach Neoplasms These results suggested that miR2045p could exert its antitumor function by inhibiting cell proliferation, migration and invasion, and promoting cell apoptosis via regulation of HER2, which may be a potential therapeutic target for gastric cancer. +genetics_overexpression_promote 32945424 hsa-mir-130a Uterine Cervical Neoplasms RUNX3 was identified as the target gene of miR130a3p, and overexpression of RUNX3 eliminated the tumorpromoting effect of miR130a3p mimics on CC cells. +genetics_knock down_promote 32945422 hsa-mir-130a Leukemia, Myeloid, Acute Therefore, miR130a knockdown is a potential therapeutic strategy for Adrresistant AML. +lncRNA target 32945416 hsa-mir-338 Esophageal Squamous Cell Carcinoma On the whole, the findings of the present study demonstrate that BANCR inhibition blocks ESCC progression by inactivating the IGF1R/Raf/MEK/ERK pathway by sponging miR3383p. +other 32945407 hsa-mir-148a Glomerulonephritis, IGA Among these differentially expressed miRNAs, most showed novel associations with IgAN, except miR148a3p, miR184 and miR200a. +other 32945407 hsa-mir-184 Glomerulonephritis, IGA Among these differentially expressed miRNAs, most showed novel associations with IgAN, except miR148a3p, miR184 and miR200a. +other 32945407 hsa-mir-200a Glomerulonephritis, IGA Among these differentially expressed miRNAs, most showed novel associations with IgAN, except miR148a3p, miR184 and miR200a. +lncRNA target 32945401 hsa-mir-15a Epilepsy, Temporal Lobe In conclusion, the results of the present study suggested that the upregulation of miR15a may inhibit cell apoptosis and inflammation in TLE by targeting GFAP, thus providing a potential therapeutic target for the treatment of TLE. +lncRNA target 32945401 hsa-mir-15a Inflammation In conclusion, the results of the present study suggested that the upregulation of miR15a may inhibit cell apoptosis and inflammation in TLE by targeting GFAP, thus providing a potential therapeutic target for the treatment of TLE. +other 32945390 hsa-mir-29a Diabetic Nephropathies SSc fibroblast transfection with microRNA29a resulted in a decreased TIMP1 expression, but also decreased the protein expression of alpha2AP. +other 32945390 hsa-mir-29a Scleroderma, Systemic SSc fibroblast transfection with microRNA29a resulted in a decreased TIMP1 expression, but also decreased the protein expression of alpha2AP. +transcription factor target 32945381 hsa-mir-92a Carcinoma, Non-Small-Cell Lung Inhibition of miR92a significantly suppressed viability of NSCLC cells, with concomitant downregulation of key proliferative genes, such as proliferating cell nuclear antigen and Ki67. +other 32945379 hsa-mir-514a Carcinoma, Non-Small-Cell Lung By using reverse transcriptionquantitative polymerase chain reaction (RTqPCR), it was found that the expression of LUCAT1 was elevated and that of microRNA514a3p (miR514a3p) was decreased in DDPresistant NSCLC tissues and cells. On the whole, the findings of the present study demonstrate that LUCAT1 contributes to the resistance of NSCLC cells to cisplatin by regulating the miR514a3p/ULK1 axis, elucidating a novel regulatory network in cisplatin resistance in NSCLC. +lncRNA target 32945370 hsa-mir-28 Breast Neoplasms Taken together, the findings of the present study demonstrate that miR285p inhibits the migration of breast cancer cells by regulating WSB2 expression, and the miR285p/WSB2 axis may be a novel therapeutic target in breast cancer. +other 32945363 hsa-mir-483 Osteoporosis The results revealed that miR4833p expression was decreased in bone tissue samples from patients with osteoporosis. +other 32945356 hsa-mir-133a Plaque, Atherosclerotic Vascular endothelial cell apoptosis is regulated by microRNA133a (miR133a), which participates in the formation of atherosclerotic (AS) plaques, leading to the development of several cardiovascular diseases. +other 32945356 hsa-mir-133a Cardiovascular Diseases Vascular endothelial cell apoptosis is regulated by microRNA133a (miR133a), which participates in the formation of atherosclerotic (AS) plaques, leading to the development of several cardiovascular diseases. +genetics_overexpression_promote 32945353 hsa-mir-15a Uterine Cervical Neoplasms Notably, overexpression of YAP1 abrogated the tumor suppressive effects of miR15a5p in CC cells. +lncRNA target 32945347 hsa-mir-7 Hypoxia Whether ICS II affected hypoxiainjured cells via miR75p was subsequently examined, and the target of miR75p was also investigated by bioinformatics analysis and luciferase reporter assays. In summary, ICS II reduces hypoxic injury in H9c2 cells via the miR75p/BTG2 axis and activation of the PI3K/Akt signaling pathway. +transcription factor target 32945196 hsa-mir-370 Nasopharyngeal Carcinoma Baohuoside-I inhibited EMT and metastasis and upregulated miR3p in NPC cells, which was shown to directly recognize and inhibit expression of Hedgehog pathway component Smoothened (SMO). +tissue_expression_ns 32944617 hsa-mir-34a Squamous Cell Carcinoma of Head and Neck We recently reported a novel role for nerve-cancer crosstalk, demonstrating that tumor protein p53 (TP53) deficiency in head and neck squamous cell carcinoma leads to a decrease in miR-34a in tumor-shed vesicles. +other 32944521 hsa-mir-21 Spinal Cord Injuries Specifically, miR5p was the most significantly upregulated miR in all SCI groups. +transcription factor target 32944398 hsa-mir-56 Glioblastoma Dysregulated miRNAs were identified after LY2109761 (a TbetaRI/II inhibitor) treatment in a mesGBM-derived cell line, and novel_miR56 was selected as a promising candidate for further functional verification. Conclusions: In summary, we provide novel insight into TGFbeta signaling-mediated pathogenesis in mesGBM and TGFbeta signaling-induced novel_miR56 may be a novel target for mesGBM management. +circulation_biomarker_diagnosis_up 32944397 hsa-mir-339 Carcinoma, Non-Small-Cell Lung 3p expression could be a potential blood-based biomarker for NSCLC. +genetics_overexpression_promote 32944348 hsa-mir-212 Esophageal Squamous Cell Carcinoma 3p overexpression and interference with SOX4 significantly inhibited the proliferation and invasion of ESCC EC970 cells, and promoted apoptosis. +other 32944003 hsa-mir-19a Sepsis CONCLUSION: Therefore, THRIL is upregulated in sepsis and may sponge miR-19a to upregulate TNF-alpha, thereby promoting lung cell apoptosis. +circRNA target 32944002 hsa-mir-512 Triple Negative Breast Neoplasms CONCLUSION: CircUBE2D2 promoted TNBC progression and doxorubicin resistance through acting as a sponge of miR3p to up-regulate CDCA3 expression. +target gene 32943997 hsa-mir-31 Prostatic Neoplasms Down-regulation of lncRNA UCA1 enhances radiosensitivity in prostate cancer by suppressing EIF4G1 expression via sponging miR-331-3p. +genetics_knock down_promote 32943995 hsa-mir-596 Carcinoma, Ovarian Epithelial Then BRD4 and KPNA4, whose knockdown led to restraining effects on cell growth and stemness, were both revealed to be targeted by miR-596 in EOC. +other 32943991 hsa-mir-221 Pancreatic Neoplasms MicroRNA-221-3p is related to survival and promotes tumour progression in pancreatic cancer +other 32943989 hsa-mir-25 Uterine Cervical Neoplasms LncRNA JPX promotes cervical cancer progression by modulating miR-25-3p/SOX4 axis. +lncRNA target 32943985 hsa-mir-93 Ovarian Neoplasms The study found that XIST can affect the expression of KMT2C in the ovarian cancer via targeting miR5p. +other 32943930 hsa-mir-613 Carcinoma, Non-Small-Cell Lung CONCLUSION: Exo-miR-613 reversed chemoresistance to DDP in NSCLC cell to involve in the process of tumor progression, and might be a potential therapeutic strategy for NSCLC. +genetics_overexpression_promote 32943928 hsa-mir-21 Carcinoma, Non-Small-Cell Lung In addition, overexpression of SNHG9 attenuated the enhancing effects of miR-21 on NSCLC proliferation. +genetics_overexpression_promote 32943926 hsa-mir-107 Uterine Cervical Neoplasms Overexpression of DCST1-AS1 and miR-107 was achieved in CSCC tissues to explore the interaction between them. +genetics_overexpression_suppress 32943922 hsa-mir-29a Carcinoma, Hepatocellular GUCD1 was a target gene of miR-29a-3p, and GUCD1 overexpression restored the effect of miR-29a-3p on HCC cell development. +genetics_knock down_suppress 32943921 hsa-mir-149 Carcinoma, Hepatocellular CONCLUSION: Knockdown of HOTAIR enhances DDP-resistant NSCLC cells to overcome cisplatin resistance partially via regulating miR5p/DCLK1 axis. +genetics_knock down_suppress 32943921 hsa-mir-149 Carcinoma, Non-Small-Cell Lung CONCLUSION: Knockdown of HOTAIR enhances DDP-resistant NSCLC cells to overcome cisplatin resistance partially via regulating miR5p/DCLK1 axis. +genetics_knock down_suppress 32943920 hsa-mir-515 Carcinoma, Non-Small-Cell Lung CONCLUSION: MALAT1 knockdown repressed NSCLC tumorigenicity by inhibiting cell proliferation, invasion and promoting apoptosis through regulating miR +genetics_overexpression_promote 32943917 hsa-mir-424 Squamous Cell Carcinoma of Head and Neck 5p mediated the repression of exosomal circGDI2 overexpression on OSCC cell malignant behaviors, and miR +target gene 32943916 hsa-mir-501 Prostatic Neoplasms Circ-ZNF609 Accelerates the Radioresistance of Prostate Cancer Cells by Promoting the Glycolytic Metabolism Through miR-501-3p/HK2 Axis. +transcription factor target 32943906 hsa-mir-214 Heart Failure CONCLUSION: In conclusion, it might be postulated that one of the mechanisms by which carvedilol may exert its cardioprotective effects can be through increasing miR-1 and miR-214 expressions which may also serve as a potential therapeutic target in patients with systolic HF in future. +transcription factor target 32943906 hsa-mir-1 Heart Failure CONCLUSION: In conclusion, it might be postulated that one of the mechanisms by which carvedilol may exert its cardioprotective effects can be through increasing miR-1 and miR-214 expressions which may also serve as a potential therapeutic target in patients with systolic HF in future. +circulation_biomarker_diagnosis_up 32943895 hsa-mir-21 Diabetes, Gestational RESULTS: miR-21 is down-regulated in the serum and placenta of GDM patients compared to normal pregnant women. +target gene 32943878 hsa-mir-141 Stomach Neoplasms LncRNA SNHG15 Contributes to Immuno-Escape of Gastric Cancer Through Targeting miR141/PD-L1. +genetics_knock down_suppress 32943877 hsa-mir-183 Esophageal Neoplasms Knockdown of miR-183 Enhances the Cisplatin-Induced Apoptosis in Esophageal Cancer Through Increase of FOXO1 Expression. +transcription factor target 32943729 hsa-mir-185 Carcinoma, Renal Cell 5p effect on VEGF-A was reversed via AR's positive regulation on the HIF2alpha-increased VEGF-A expression that resulted in increasing VEGF-A in the VHL-wt RCC cells. +genetics_overexpression_promote 32942974 hsa-mir-20b Pancreatic Carcinoma In order to identify the effects of miR-320b on cell growth, we overexpressed miR-320b in PANC-1 and FG pancreatic cancer cell lines, CCK8 and BrdU incorporation assay results showed that miR-320b inhibited cell proliferation. +exosome 32942233 hsa-mir-96 Pancreatic Carcinoma Collectively, these results indicate that hypoxic exosomal UCA1 could promote angiogenesis and tumor growth through the miR5p/AMOTL2/ERK1/2 axis and therefore, serve as a novel target for PC treatment. +lncRNA target 32942015 hsa-mir-103a Parkinson Disease These findings suggested that miR-103a-3p inhibition has neuroprotective effects in PD, which may be involved in regulating mitophagy through the Parkin/Ambra1 pathway. +circulation_biomarker_diagnosis_ns 32941675 hsa-mir-155 Granulomatous Mastitis This study investigates whether the circulating miR-155, let-7c, miR-21, and PTEN levels to be used in the differential diagnosis of patients with idiopathic granulomatous mastitis (IGM) and breast cancer (BC). +circulation_biomarker_diagnosis_ns 32941675 hsa-let-7c Breast Neoplasms This study investigates whether the circulating miR-155, let-7c, miR-21, and PTEN levels to be used in the differential diagnosis of patients with idiopathic granulomatous mastitis (IGM) and breast cancer (BC). +circulation_biomarker_diagnosis_ns 32941675 hsa-mir-155 Breast Neoplasms This study investigates whether the circulating miR-155, let-7c, miR-21, and PTEN levels to be used in the differential diagnosis of patients with idiopathic granulomatous mastitis (IGM) and breast cancer (BC). +circulation_biomarker_diagnosis_ns 32941675 hsa-mir-21 Granulomatous Mastitis This study investigates whether the circulating miR-155, let-7c, miR-21, and PTEN levels to be used in the differential diagnosis of patients with idiopathic granulomatous mastitis (IGM) and breast cancer (BC). +circulation_biomarker_diagnosis_ns 32941675 hsa-let-7c Granulomatous Mastitis This study investigates whether the circulating miR-155, let-7c, miR-21, and PTEN levels to be used in the differential diagnosis of patients with idiopathic granulomatous mastitis (IGM) and breast cancer (BC). +circulation_biomarker_diagnosis_ns 32941675 hsa-mir-21 Breast Neoplasms This study investigates whether the circulating miR-155, let-7c, miR-21, and PTEN levels to be used in the differential diagnosis of patients with idiopathic granulomatous mastitis (IGM) and breast cancer (BC). +circulation_biomarker_diagnosis_up 32941517 hsa-mir-103a Fibromyalgia Here, we cluster-wise assessed relative gene expression of miR103a-3p, miR107, miR130a-3p, and miR125a-5p in white blood cell (WBC) RNA of 31 FMS patients and 16 healthy controls. +circulation_biomarker_diagnosis_up 32941517 hsa-mir-107 Fibromyalgia Here, we cluster-wise assessed relative gene expression of miR103a-3p, miR107, miR130a-3p, and miR125a-5p in white blood cell (WBC) RNA of 31 FMS patients and 16 healthy controls. +other 32941074 hsa-mir-142 Nasopharyngeal Neoplasms A three-miRNA signature (has-miR3p, has-miR-29c, and has-miR-30e) was obviously associated with the overall survival of nasopharyngeal carcinoma patients. +other 32941074 hsa-mir-29c Nasopharyngeal Neoplasms A three-miRNA signature (has-miR3p, has-miR-29c, and has-miR-30e) was obviously associated with the overall survival of nasopharyngeal carcinoma patients. +genetics_GWAS 32940422 hsa-mir-148 Pneumonia, Ventilator-Associated Chronic obstructive pulmonary disease patients carrying the AA/AG genotypes of miR-148 rs4719839 single nucleotide polymorphism (SNP) were more prone to VAP due to the higher expression of miR-148, TNF-alpha and IL-6 along with suppressed expression of ATG16L1, Beclin-I and LC3-II in their serum and PBMCs. +other 32940379 hsa-let-7b Atrial Fibrillation The expressions of miR-92b-3p, miR5p, and miR-let-7b-3p had differences between patients with AF and SR. +other 32940379 hsa-mir-92b Atrial Fibrillation The expressions of miR-92b-3p, miR5p, and miR-let-7b-3p had differences between patients with AF and SR. +other 32940379 hsa-mir-1306 Atrial Fibrillation The expressions of miR-92b-3p, miR5p, and miR-let-7b-3p had differences between patients with AF and SR. +circRNA target 32940102 hsa-mir-615a Thyroid Cancer, Papillary Moreover, circ-NCOR2 enhanced the expression of metastasis-associated protein 2 (MTA2) by sponging miR-615a-5p, thereby facilitating PTC cell progression. CONCLUSIONS: Taken together, our findings reveal a novel circ-NCOR2/miR-615a-5p/MTA2 axis in PTC, which could become a potential therapeutic target for this disease. +genetics_overexpression_suppress 32940078 hsa-mir-505 Carcinoma, Hepatocellular The overexpression of miR-505 in HCC cells inhibited cell proliferation and metastasis, as well as enhanced cell apoptosis by directly downregulating heterogeneous nuclear ribonucleoprotein M (HNRNPM). +other 32940043 hsa-mir-375 Carcinoma, Non-Small-Cell Lung The expression of circ_0086720 and SPIN1 was increased in the radioresistant NSCLC tissues, while miR-375 expression was decreased. To conclude, circ_0086720 downregulation enhanced the sensitivity of NSCLC to radiation by regulating the miR-375/SPIN1 axis, contributing to the improvement of the radiotherapies in NSCLC. +exosome 32939962 hsa-mir-92a Myocardial Infarction, Acute HBO significantly increased MALAT1 expression in cardiac myocytes and HBO-induced MALAT1 and exosomes attenuated miR-92a expression after myocardial infarction. HBO-induced exosomes from cardiac myocytes up-regulate MALAT1 to suppress miR-92a expression and counteract the inhibitory effect of miR-92a on KLF2 and CD31 expression in left ventricular myocardium after myocardial infarction to enhance neovascularization. +transcription factor target 32939938 hsa-mir-34b Respiratory Syncytial Virus Infections Our results showed that hsa-mir-34b-5p and hsa-mir-34c-5p decreased significantly in HBECs after RSV infection. In RSV-infected HBECs, the inducement of MUC5AC production by decreased hsa-mir-34b/c-5p was partly mediated through activation of c-Jun. +target gene 32939872 hsa-mir-149 Abortion, Habitual Inhibition of microRNA-149 protects against recurrent miscarriage through upregulating RUNX2 and activation of the PTEN/Akt signaling pathway. +other 32939184 hsa-mir-1231 Carcinoma, Non-Small-Cell Lung However, the prognostic value of miR-1231 in NSCLC patients with comorbid diabetes mellitus (DM) remains unclear. CONCLUSION: MiR-1231 reduced the risk of cancer-related death in patients with combined NSCLC and DM. +other 32939184 hsa-mir-1231 Diabetes Mellitus However, the prognostic value of miR-1231 in NSCLC patients with comorbid diabetes mellitus (DM) remains unclear. CONCLUSION: MiR-1231 reduced the risk of cancer-related death in patients with combined NSCLC and DM. +other 32939143 hsa-mir-21 Dermatitis, Allergic Contact CONCLUSION: These preliminary results showed that miR-155 and miR-21 may play a role in the pathogenesis of allergic contact dermatitis, but further studies are needed to clarify their definite roles. +other 32939143 hsa-mir-155 Dermatitis, Allergic Contact CONCLUSION: These preliminary results showed that miR-155 and miR-21 may play a role in the pathogenesis of allergic contact dermatitis, but further studies are needed to clarify their definite roles. +genetics_knock down_promote 32939058 hsa-mir-126 Ovarian Neoplasms Coherently, knockdown of METTL3 inhibited the effect of miR +circulation_biomarker_prognosis_ns 32938467 hsa-mir-381 Leukemia, Myeloid, Acute CONCLUSION: All experimental results confirm that miR-381 has reduced bone marrow and serum expression in pediatric AML, and low levels of serum miR-381 have certain diagnostic and prognostic value in pediatric AML and may be a potential therapeutic target for AML. +lncRNA target 32938459 hsa-mir-342 Carcinoma, Non-Small-Cell Lung 3p inhibited NSCLC growth and metastasis both in vitro and in vivo. +other 32938310 hsa-mir-182 Triple Negative Breast Neoplasms We previously showed that microRNA-182 (miR-182) might promote cell proliferation and migration in triple-negative breast cancer (TNBC). This study aimed to investigate circular RNAs (circRNAs) that interact with miR-182 and play important roles in TNBC. +circulation_biomarker_diagnosis_ns 32937907 hsa-mir-21 Rectal Neoplasms We investigated miR-21 as tissue and plasma biomarker of response to CRT in a prospective cohort of RC patients; The expression of miR-21 was analyzed in pre- and post-CRT rectal tissue and plasma in 37 patients with RC. This is one of the first studies on circulating miR-21 as a potential biomarker of response to CRT in RC patients. +lncRNA target 32937635 hsa-mir-217 Stomach Neoplasms CONCLUSION: An EMT-associated pathway (the HOTAIR-miRZEB1 axis) appears to inhibit peritoneal dissemination and could lead to a novel therapeutic strategy against scirrhous gastric cancer in humans. +other 32937248 hsa-mir-1 Cardiotoxicity miR-1 has been shown to provide diagnostic and prognostic information in the setting of myocardial infarction, but changes in its levels are controversial in doxorubicin-treated breast cancer patients with cardiotoxicity. +other 32937248 hsa-mir-210 Breast Neoplasms CONCLUSION: The data suggest that let-7f, miR-1, miR-20a, miR-126 and miR-210 are associated with anthracycline-based cardiotoxicity during chemotherapy in breast cancer patients. +other 32937248 hsa-mir-1 Breast Neoplasms miR-1 has been shown to provide diagnostic and prognostic information in the setting of myocardial infarction, but changes in its levels are controversial in doxorubicin-treated breast cancer patients with cardiotoxicity. +other 32937248 hsa-mir-20a Breast Neoplasms CONCLUSION: The data suggest that let-7f, miR-1, miR-20a, miR-126 and miR-210 are associated with anthracycline-based cardiotoxicity during chemotherapy in breast cancer patients. +other 32937248 hsa-mir-210 Cardiotoxicity CONCLUSION: The data suggest that let-7f, miR-1, miR-20a, miR-126 and miR-210 are associated with anthracycline-based cardiotoxicity during chemotherapy in breast cancer patients. +other 32937248 hsa-let-7f Cardiotoxicity CONCLUSION: The data suggest that let-7f, miR-1, miR-20a, miR-126 and miR-210 are associated with anthracycline-based cardiotoxicity during chemotherapy in breast cancer patients. +other 32937248 hsa-mir-126 Breast Neoplasms CONCLUSION: The data suggest that let-7f, miR-1, miR-20a, miR-126 and miR-210 are associated with anthracycline-based cardiotoxicity during chemotherapy in breast cancer patients. +other 32937248 hsa-mir-126 Cardiotoxicity CONCLUSION: The data suggest that let-7f, miR-1, miR-20a, miR-126 and miR-210 are associated with anthracycline-based cardiotoxicity during chemotherapy in breast cancer patients. +other 32937248 hsa-let-7f Breast Neoplasms CONCLUSION: The data suggest that let-7f, miR-1, miR-20a, miR-126 and miR-210 are associated with anthracycline-based cardiotoxicity during chemotherapy in breast cancer patients. +other 32937248 hsa-mir-20a Cardiotoxicity CONCLUSION: The data suggest that let-7f, miR-1, miR-20a, miR-126 and miR-210 are associated with anthracycline-based cardiotoxicity during chemotherapy in breast cancer patients. +genetics_overexpression_promote 32937160 hsa-mir-885 Liver Neoplasms Overexpression of miR-885 resulted in significant (P < 0.05) decline in the proliferation of liver cancer cells. +other 32936670 hsa-mir-1283 Dry Eye Syndromes Compared with the low miR-450b-5p, low miR-1283, low miR-3671 and high TGF-beta2 groups, the high miR-450b-5p, high miR-1283, high miR-3671 and low TGF-beta2 groups had a significantly higher probability of corneal injury (TGF-beta2: chi(2) = 5.762, P = 0.016; miR-450b-5p: chi(2) = 13.267, P < 0.001; miR-1283: chi(2) = 19.431, P < 0.001; miR-3671: chi(2) = 8.131, P = 0.004). CONCLUSION: Current model combining tear miR-450b-5p, miR-1283, miR-3671 and TGF-beta2 had important values in the identification of dry eye and was of great value in evaluating the risk of corneal injury. +other 32936670 hsa-mir-671 Dry Eye Syndromes Compared with the low miR-450b-5p, low miR-1283, low miR-3671 and high TGF-beta2 groups, the high miR-450b-5p, high miR-1283, high miR-3671 and low TGF-beta2 groups had a significantly higher probability of corneal injury (TGF-beta2: chi(2) = 5.762, P = 0.016; miR-450b-5p: chi(2) = 13.267, P < 0.001; miR-1283: chi(2) = 19.431, P < 0.001; miR-3671: chi(2) = 8.131, P = 0.004). CONCLUSION: Current model combining tear miR-450b-5p, miR-1283, miR-3671 and TGF-beta2 had important values in the identification of dry eye and was of great value in evaluating the risk of corneal injury. +other 32936670 hsa-mir-450b Dry Eye Syndromes Compared with the low miR-450b-5p, low miR-1283, low miR-3671 and high TGF-beta2 groups, the high miR-450b-5p, high miR-1283, high miR-3671 and low TGF-beta2 groups had a significantly higher probability of corneal injury (TGF-beta2: chi(2) = 5.762, P = 0.016; miR-450b-5p: chi(2) = 13.267, P < 0.001; miR-1283: chi(2) = 19.431, P < 0.001; miR-3671: chi(2) = 8.131, P = 0.004). CONCLUSION: Current model combining tear miR-450b-5p, miR-1283, miR-3671 and TGF-beta2 had important values in the identification of dry eye and was of great value in evaluating the risk of corneal injury. +lncRNA target 32936498 hsa-mir-1286 Osteosarcoma The microRNA (miRNA)-1286 was downregulated, while RAB31 upregulated in OS tissues and cells. GANT61 inhibited viability, migration, and invasion ability of OS cells (SaOS-2 and U2OS), and induced apoptosis and the ROS production, along with miRNA-1286 upregulation and RAB13 downregulation. +lncRNA target 32936290 hsa-mir-769 Uterine Cervical Neoplasms Taken together, our results demonstrate that RP11-284F21.9 functions as tumor suppressor and regulates PPWD1 expression through competitively binding to miR +lncRNA target 32935999 hsa-mir-944 Pituitary Neoplasms SNHG6 and miR-994 can serve as novel valuable therapeutic targets for IPA. +transcription factor target 32935891 hsa-mir-146a Dry Eye Syndromes The results of databases showed that IRAK1 was one of the target genes regulated by miRNA-146a-5p, and it is related to dry eye disease. +other 32934814 hsa-mir-1 Cardiomegaly a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-199a Diabetic Nephropathies a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-15b Cardiomegaly a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-191 Cardiomegaly a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-29a Diabetic Nephropathies a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-29a Cardiomegaly a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-191 Diabetic Nephropathies a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-17 Diabetic Nephropathies a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-199a Cardiomegaly a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-17 Cardiomegaly a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-21 Cardiomegaly a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-28 Cardiomegaly a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-28 Diabetic Nephropathies a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-222 Diabetic Nephropathies a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-26a Cardiomegaly a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-26a Diabetic Nephropathies a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-222 Cardiomegaly a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-22 Diabetic Nephropathies a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-1 Diabetic Nephropathies a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-22 Cardiomegaly a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-101 Diabetic Nephropathies a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-21 Diabetic Nephropathies a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-34a Cardiomegaly a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-15b Diabetic Nephropathies a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-101 Cardiomegaly a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-34a Diabetic Nephropathies a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-208a Diabetic Nephropathies a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-146a Diabetic Nephropathies a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-208a Cardiomegaly a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-195 Cardiomegaly a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-146a Cardiomegaly a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +other 32934814 hsa-mir-195 Diabetic Nephropathies a, miR-29c, miR-30c, miR-101, miR-146a, miR-191, miR-208a-5p and miR-328) were analyzed and compared with echocardiographic examination results. +genetics_overexpression_promote 32934775 hsa-mir-192 Hypopharyngeal Neoplasms We demonstrate that the administration of BAY 11-7082, either before or after acidic bile, eliminates NF-kappaB activation, prevents overexpression of Bcl2, Rela, Stat3, Egfr, Tnf, Wnt5a, and deregulations of miR-192, miR-504, linked to bile reflux-related hypopharyngeal cancer. +target gene 32934740 hsa-mir-19a Osteosarcoma Downregulation of miR-19a inhibits the proliferation and promotes the apoptosis of osteosarcoma cells by regulating the JAK2/STAT3 pathway. +lncRNA target 32934732 hsa-mir-101 Squamous Cell Carcinoma of Head and Neck Collectively, these findings revealed that upregulation of MALAT1 facilitated OSCC proliferation and invasion by targeting the miR-101/EZH2 axis. +target gene 32934728 hsa-mir-23b Pancreatic Neoplasms MicroRNA-23b-3p promotes pancreatic cancer cell tumorigenesis and metastasis via the JAK/PI3K and Akt/NF-κB signaling pathways. +other 32934703 hsa-mir-34a Nasopharyngeal Carcinoma Moreover, the expression of miR-34a can be used as a potential predictor of the efficacy of CCRT in patients with NPC. +target gene 32934702 hsa-mir-375 Osteosarcoma lncRNA TUSC7 inhibited the proliferation and migration of MG63 osteosarcoma cells by regulating miR-375. +target gene 32934696 hsa-mir-221 Liver Neoplasms Low HOXC10 expression in liver cancer regulates proliferation via a mechanism involving miR-221 and the MAPK signaling pathway. +lncRNA target 32934693 hsa-mir-451a Colorectal Neoplasms The results demonstrated that linc00467 targets and regulates the expression of microRNA (miR)-451a, promoting carcinogenesis and metastasis in CRC. In conclusion, the results of the present study indicate that increased linc00467 expression promotes metastasis by targeting miR-451a, which ultimately increases cellular proliferation and inhibits apoptosis in human CRC cells. +genetics_knock down_promote 32934680 hsa-mir-4728 Carcinoma, Non-Small-Cell Lung By conducting gain- and loss-of-function experiments, the results indicated that miR-4728 knockdown significantly promoted NSCLC cell proliferation, migration and invasion compared with the inhibitor negative control (NC) group. +genetics_knock down_promote 32934674 hsa-mir-20a Retinoblastoma Subsequently, gain- or loss-of-function experiments for miR-320a and tumor suppressor candidate 3 (TUSC3) were performed to study the role of miR-320a/TUSC3 in retinoblastoma cells. +circulation_biomarker_diagnosis_down 32934668 hsa-mir-146a Ankle Fractures The results demonstrated that miR-146a was significantly downregulated in the blood of patients with ankle fracture. +circulation_biomarker_diagnosis_down 32934667 hsa-mir-15a Acute Lung Injury Further analyses indicated that downregulation of miR-15a-5p significantly relieved acute lung injury induced by THS, evidenced by a decreased ratio of Evan's blue dye (EBD) in the BALF to EBD in plasma of THS rats, decreased lung permeability index and reduced lung wet/dry ratio. +circulation_biomarker_diagnosis_down 32934667 hsa-mir-15a Shock, Hemorrhagic Further analyses indicated that downregulation of miR-15a-5p significantly relieved acute lung injury induced by THS, evidenced by a decreased ratio of Evan's blue dye (EBD) in the BALF to EBD in plasma of THS rats, decreased lung permeability index and reduced lung wet/dry ratio. +other 32934245 hsa-mir-146a Diabetes Mellitus Results indicate that diabetes significantly upregulated the expression levels of miR-146a, miR-9, TNF-alpha, NF-kappaB, and subsequently AbetaPP, BACE1, and Bax. +other 32934245 hsa-mir-9 Diabetes Mellitus Results indicate that diabetes significantly upregulated the expression levels of miR-146a, miR-9, TNF-alpha, NF-kappaB, and subsequently AbetaPP, BACE1, and Bax. +other 32934214 hsa-mir-337 Breast Neoplasms In conclusion, the above results denoted that activation of miR3p/STAT3 axis might be a potential pathway for the increasing metastasis of breast cancer under chronic stress. +transcription factor target 32934206 hsa-mir-29b Breast Neoplasms Moreover, we identified for the first time a c-myc/miR-29b-3p/CDK6 axis in breast cancer that could be responsible for c-myc-induced palbociclib insensitivity, in which c-myc activation resulted in downregulation of miR-29b-3p, further activated CDK6 and inhibited cell-cycle arrest at G(1) phase. +circulation_biomarker_diagnosis_ns 32934118 hsa-mir-122 Dengue Importantly, receiver operating curve analysis further confirmed that the plasma expression pattern of hsa-miR5p could differentiate between different stages of dengue infection (area under the concentration-time curve [AUC] = 0.792), and dengue-negative patients with other febrile illnesses (AUC = 0.984). +circulation_biomarker_diagnosis_up 32933626 hsa-mir-17 Nephrotic Syndrome 5p in peripheral blood in children with NS. +circRNA target 32933544 hsa-mir-29a Liver Cirrhosis CONCLUSIONS: Our data suggests TGF-beta1-miR29a-Fstl1 regulatory circuit plays a key role in regulation the HSC activation and ECM production, and targeting Fstl1 may be a strategy for the treatment of liver fibrosis. +other 32933226 hsa-mir-34a Nerve Degeneration Additionally, there was downregulation of CREB and SIRT1 mRNAs and neurodegeneration-associated miRNA21a-5p and miRNA34a-5p. +other 32933141 hsa-mir-375 Non-alcoholic Fatty Liver Disease Subsequently, the expression of miR-122, miR-34a, miR-375, miR-16 and miR-21 was significantly increased in Obese DM and Obese DM(FI) group as compared to healthy control. +other 32933141 hsa-mir-34a Non-alcoholic Fatty Liver Disease Subsequently, the expression of miR-122, miR-34a, miR-375, miR-16 and miR-21 was significantly increased in Obese DM and Obese DM(FI) group as compared to healthy control. +other 32933141 hsa-mir-122 Non-alcoholic Fatty Liver Disease Subsequently, the expression of miR-122, miR-34a, miR-375, miR-16 and miR-21 was significantly increased in Obese DM and Obese DM(FI) group as compared to healthy control. +other 32933141 hsa-mir-16 Non-alcoholic Fatty Liver Disease Subsequently, the expression of miR-122, miR-34a, miR-375, miR-16 and miR-21 was significantly increased in Obese DM and Obese DM(FI) group as compared to healthy control. +other 32933141 hsa-mir-21 Non-alcoholic Fatty Liver Disease Subsequently, the expression of miR-122, miR-34a, miR-375, miR-16 and miR-21 was significantly increased in Obese DM and Obese DM(FI) group as compared to healthy control. +lncRNA target 32932948 hsa-mir-99a Adenocarcinoma of Lung Our in silico analysis revealed 23 putative target genes of pre-miR-99a in LUAD cells. +exosome 32932883 hsa-mir-181a Precursor Cell Lymphoblastic Leukemia-Lymphoma Silencing of Exosomal miR-181a Reverses Pediatric Acute Lymphocytic Leukemia Cell Proliferation. +other 32932713 hsa-mir-221 Thyroid Neoplasms Sensitivity analysis revealed a significant association between the higher expression of miR-146b, miR-221, and miR-222 and the recurrence of papillary TC (OR = 9.11, 95% CI 3.00 to 27.52; p < 0.001; OR = 3.88, 95% CI 1.34 to 11.19, p < 0.001; OR = 6.56, 95% CI 2.75 to 15.64, p < 0.001). This research identified that miR-146b, miR-221, and miR-222 could serve as potential prognostic biomarkers in TC, particularly in PTC. +other 32932713 hsa-mir-222 Thyroid Neoplasms Sensitivity analysis revealed a significant association between the higher expression of miR-146b, miR-221, and miR-222 and the recurrence of papillary TC (OR = 9.11, 95% CI 3.00 to 27.52; p < 0.001; OR = 3.88, 95% CI 1.34 to 11.19, p < 0.001; OR = 6.56, 95% CI 2.75 to 15.64, p < 0.001). This research identified that miR-146b, miR-221, and miR-222 could serve as potential prognostic biomarkers in TC, particularly in PTC. +other 32932713 hsa-mir-146b Thyroid Neoplasms Sensitivity analysis revealed a significant association between the higher expression of miR-146b, miR-221, and miR-222 and the recurrence of papillary TC (OR = 9.11, 95% CI 3.00 to 27.52; p < 0.001; OR = 3.88, 95% CI 1.34 to 11.19, p < 0.001; OR = 6.56, 95% CI 2.75 to 15.64, p < 0.001). This research identified that miR-146b, miR-221, and miR-222 could serve as potential prognostic biomarkers in TC, particularly in PTC. +other 32932426 hsa-mir-65 Aagenaes syndrome miR-299 (1.73-fold change, p = 0.034) and miR-365 (1.46-fold change, p = 0.011) were upregulated and miR-30c (0.72-fold change, p = 0.0037), miR-652 (0.85-fold change, p = 0.025), and miR-744 (0.72-fold change, p = 0.0069) were downregulated in patients with Aagenaes syndrome at birth compared to controls. +other 32932426 hsa-mir-744 Aagenaes syndrome miR-299 (1.73-fold change, p = 0.034) and miR-365 (1.46-fold change, p = 0.011) were upregulated and miR-30c (0.72-fold change, p = 0.0037), miR-652 (0.85-fold change, p = 0.025), and miR-744 (0.72-fold change, p = 0.0069) were downregulated in patients with Aagenaes syndrome at birth compared to controls. +other 32932426 hsa-mir-299 Aagenaes syndrome miR-299 (1.73-fold change, p = 0.034) and miR-365 (1.46-fold change, p = 0.011) were upregulated and miR-30c (0.72-fold change, p = 0.0037), miR-652 (0.85-fold change, p = 0.025), and miR-744 (0.72-fold change, p = 0.0069) were downregulated in patients with Aagenaes syndrome at birth compared to controls. +other 32932426 hsa-mir-652 Aagenaes syndrome miR-299 (1.73-fold change, p = 0.034) and miR-365 (1.46-fold change, p = 0.011) were upregulated and miR-30c (0.72-fold change, p = 0.0037), miR-652 (0.85-fold change, p = 0.025), and miR-744 (0.72-fold change, p = 0.0069) were downregulated in patients with Aagenaes syndrome at birth compared to controls. +circRNA target 32932275 hsa-mir-362 Carcinoma, Non-Small-Cell Lung In conclusion, Circ_0074027 contributed to the progression of NSCLC through promoting the proliferation and motility while hampering the apoptosis of NSCLC cells via miR +lncRNA target 32932199 hsa-mir-582 Colorectal Neoplasms We found that dysregulation of lncRNAs such as PCBP1-AS1, UCA1 and SNHG16 could sequester several miRNAs such as hsa-miR5p and hsa-miR-198 and promote the proliferation, invasion and drug resistance of colorectal cancer cells. +genetics_GWAS 32931917 hsa-mir-129 Pulmonary Disease, Chronic Obstructive CONCLUSION: It suggested that polymorphisms of MIR2113 and MIR129-LEP might be linked with the susceptibility of COPD among the Chinese Han population. +genetics_GWAS 32931917 hsa-mir-2113 Pulmonary Disease, Chronic Obstructive CONCLUSION: It suggested that polymorphisms of MIR2113 and MIR129-LEP might be linked with the susceptibility of COPD among the Chinese Han population. +circulation_biomarker_diagnosis_up 32931801 hsa-mir-135b Colorectal Neoplasms Moreover, stool miR-135b-5p exhibited a better diagnostic performance in distinguishing the different TNM stages of CRC patients than serum miR-135b-5p. +lncRNA target 32931797 hsa-mir-15a Osteoarthritis SIGNIFICANCE: Our findings confirmed that ARFRP1 mediated LPS-induced the injury of chondrocytes through regulating NF-kappaB pathway by modulation of miR-15a-5p/TLR4 axis, providing theoretical basis for the treatment of OA patients. +genetics_knock down_promote 32931357 hsa-mir-7 Stomach Neoplasms Down-regulated Raf-1 reversed the impacts of miR-7 knockdown on GC cells (all P < 0.05). +circulation_biomarker_diagnosis_up 32931356 hsa-mir-20b Carcinoma, Hepatocellular Mechanically, WWOX-AS1 was identified as a cytoplasmic RNA in HCC cells and sponged miR-20b-5p to regulate WWOX expression. Collectively, WWOX-AS1/miR-20b-5p/WWOX axis suppresses HCC tumorigenesis, hinting a potential molecular mechanism for the therapy of HCC patients. +genetics_knock down_suppress 32930981 hsa-mir-21 Diabetic Nephropathies After the knockdown of miR +transcription factor target 32930086 hsa-mir-92a Prostatic Neoplasms Therefore, our study indicates that miR-92a inhibits the growth and metastasis of prostate cancer by targeting SOX4, and can potentially serve as a biomarker and treatment target for PCa patients. +circulation_biomarker_diagnosis_up 32929911 hsa-mir-429 Bloom Syndrome OBJECTIVE: To explore the feasibility and mechanism of inhibiting miR-429 to improve the permeability of the blood spinal cord barrier (BSCB) in vitro, and provide a new gene therapy target for enhancing the spinal cord microenvironment. +other 32929657 hsa-mir-146a Lupus Erythematosus, Systemic The T/T genotype of microRNA-146a rs2431697 was associated with lupus nephritis, higher disease activity, and autoantibodies production. The microRNA-146a rs2431697 T allele could be a potential risk factor that contributes to SLE susceptibility, development of lupus nephritis, and disease activity. +other 32929657 hsa-mir-146a Lupus Nephritis The T/T genotype of microRNA-146a rs2431697 was associated with lupus nephritis, higher disease activity, and autoantibodies production. The microRNA-146a rs2431697 T allele could be a potential risk factor that contributes to SLE susceptibility, development of lupus nephritis, and disease activity. +exosome 32929392 hsa-mir-199a Muscular Dystrophy, Duchenne We have shown that the expression of mir-199a-5p, which is known to increase in exosomes of DMD patients, is less in WJ-MSC. +lncRNA target 32929377 hsa-mir-575 Breast Neoplasms CDKN1B feedback loop in ER+ breast cancer, suggesting that miR-575 can be used as a prognostic biomarker in patients with ER+ breast cancer, as well as a predictor or a promising target for tamoxifen sensitivity. +other 32929374 hsa-mir-339 Intestinal Diseases Notably, the increased circ-PRKCB levels and decreased miR5p levels associated with murine intestinal I/R were consistent with those in patients with intestinal infarction. +genetics_overexpression_suppress 32929374 hsa-mir-339 Iron Metabolism Disorders 5p overexpression significantly downregulated p66Shc expression and attenuated oxidative stress levels and I/R injury in vivo and in vitro. +other 32929328 hsa-mir-16 Burns 5p may be a novel therapeutic approach for deep second-degree burn wound healing. +circulation_biomarker_diagnosis_up 32929219 hsa-mir-142 Papilloma, Choroid Plexus Furthermore, increased serum exosomal miR +other 32929219 hsa-mir-142 Uterine Cervical Neoplasms Here, we show that high levels of miR5p positively correlate with indoleamine 2,3-dioxygenase (IDO) expression in tumour-associated lymphatic vessels in advanced cervical squamous cell carcinoma (CSCC). +transcription factor target 32929075 hsa-mir-365a Carcinoma, Non-Small-Cell Lung In short, our findings identify a novel strategy to elevate erastin-induced ferroptosis in NSCLCs acting through the MT1DP/miR-365a-3p/NRF2 axis. +genetics_overexpression_suppress 32928707 hsa-mir-133a Stomach Neoplasms Finally, microRNA-133a inhibited gastric cancer cell proliferation, whereas RGS3 overexpression attenuated this inhibitory effect. +tissue_expression_up 32928012 hsa-mir-100 Coronary Artery Disease Here, we evaluated PBMC expression of two CAD-related inflammatory miRNAs, miR-196a and miR-100, in PBMCs of CAD patients with significant stenosis (CAD, n: 72), patients with insignificant coronary stenosis (ICAD, n: 30), and controls (n: 74) and checked whether they can segregate study groups. +tissue_expression_ns 32928012 hsa-mir-196a Coronary Artery Disease Here, we evaluated PBMC expression of two CAD-related inflammatory miRNAs, miR-196a and miR-100, in PBMCs of CAD patients with significant stenosis (CAD, n: 72), patients with insignificant coronary stenosis (ICAD, n: 30), and controls (n: 74) and checked whether they can segregate study groups. +other 32927694 hsa-mir-3 Endometrial Neoplasms We identified two upstream regulators of the DEGs, mir-33 and Brd4, and a pathway analysis identified downstream enrichment of the colorectal cancer metastasis and ovarian cancer metastasis pathways. +circRNA target 32927434 hsa-mir-495 Carcinoma, Non-Small-Cell Lung Taken together, our study found that hsa_circ_0020123 functioned like a tumor promoter via a novel hsa_circ_0020123/miR-495/HOXC9 axis, highlighting its possibility as a new NSCLC therapeutic target. +lncRNA target 32927433 hsa-mir-92a-1 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Accordingly, we show that antagomiR-mediated in vivo inhibition of miR-92a +other 32927431 hsa-mir-21 Ovarian Neoplasms SNHG12 facilitated ovarian immune escape by promoting IL-6/miR-21 crosstalk between ovarian cancer cells and M2 macrophages. +genetics_overexpression_promote 32927364 hsa-mir-18a Nasopharyngeal Carcinoma Overexpression of EBV-miR-BART10-5p and hsa-miR-18a strongly promotes angiogenesis in vitro and in vivo by regulating the expression of VEGF and HIF1-α in a Spry3-dependent manner. +virus_miRNA 32927364 ebv-mir-BART10 Nasopharyngeal Carcinoma Overexpression of EBV-miR-BART10-5p and hsa-miR-18a strongly promotes angiogenesis in vitro and in vivo by regulating the expression of VEGF and HIF1-α in a Spry3-dependent manner. +other 32926965 hsa-mir-26a Anemia, Diamond-Blackfan We propose that induction of miR-26a is a potentially novel approach to treatment of DBA and could improve anemia in DBA patients without the potentially adverse side effects of metformin in a DBA patient population. +other 32926961 hsa-let-7i Myocardial Infarction The aim of this study was to figure out the role of Testis-specific transcript Y-linked 15 (TTTY15) and let-7i-5p in cell model of MI in cardiomyocytes. +genetics_knock down_promote 32926961 hsa-let-7i Hypoxia Collectively, TTTY15 knockdown protects cardiomyocytes against hypoxia-induced apoptosis and mitochondrial energy metabolism dysfunction in vitro through let-7i-5p/TLR3/NF-kappaB pathway to suppress. +other 32926932 hsa-mir-223 Hypertension, Pulmonary Restoration of the level of miR-223 might be an effective therapeutic method for the treatment of PAH. +exosome 32926923 hsa-mir-223 Brain Ischemia 3p from MSCs attenuated cerebral ischemia/reperfusion injury through inhibiting microglial M1 polarization mediated pro-inflammatory response, which may be related with inhibitory effect of exosomal miR +transcription factor target 32925348 hsa-mir-21 Carcinoma, Non-Small-Cell Lung Propofol Affects Non-Small-Cell Lung Cancer Cell Biology By Regulating the miR-21/PTEN/AKT Pathway In Vitro and In Vivo. CONCLUSIONS Our study indicated that propofol inhibited A549 cell growth, accelerated apoptosis via the miR-21/PTEN/AKT pathway in vitro, suppressed NSCLC tumor cell growth, and promoted apoptosis in vivo. +transcription factor target 32925290 hsa-mir-542 Glioblastoma However, the functions of miR542 and its underlying mechanism in glioblastoma multiforme (GBM) remain largely unknown. CONCLUSION: The in vitro findings demonstrated that miR542 inhibited the migration and proliferation of U251 cells and suppressed EMT through targeting AEG-1, indicating that miR542 may be a potential anti-cancer target for GBM. +lncRNA target 32924985 hsa-mir-150 Carcinoma, Non-Small-Cell Lung METHODS: qRT-PCR was used for detecting FOXD3-AS1, miR-150 and SRC kinase signaling inhibitor 1 (SRCIN1) mRNA expression in NSCLC tissues, and the relationship between pathological characteristics of NSCLC patients and FOXD3-AS1 expression level was analyzed. CONCLUSIONS: FOXD3-AS1 indirectly enhances the expression of SRCIN1 by targeting miR-150, thereby inhibiting NSCLC progression. +genetics_overexpression_promote 32924881 hsa-mir-31 Pancreatic Carcinoma 3p activated Wnt/beta-catenin signaling in pancreatic cancer cells, and ST7L overexpression restored activation of Wnt/beta-catenin signaling. +lncRNA target 32924718 hsa-mir-140 Neuralgia CONCLUSIONS: MiR-140 could mollify CCI-stimulated neuropathic pain via targeting S1PR1, suggesting a potential therapeutic target in the treatment of neuropathic pain. +tissue_expression_down 32924699 hsa-mir-34a Bronchopulmonary Dysplasia In addition, the upregulation of Robo2 and miR17hg while the downregulation of miR-130b-3p;as well as the upregulation of Brinp1 and GM20455 but the downregulation of miR-34a-5p were validated by qPCR +tissue_expression_up 32924699 hsa-mir-130b Bronchopulmonary Dysplasia In addition, the upregulation of Robo2 and miR17hg while the downregulation of miR-130b-3p;as well as the upregulation of Brinp1 and GM20455 but the downregulation of miR-34a-5p were validated by qPCR +tissue_expression_up 32924699 hsa-mir-17 Bronchopulmonary Dysplasia In addition, the upregulation of Robo2 and miR17hg while the downregulation of miR-130b-3p;as well as the upregulation of Brinp1 and GM20455 but the downregulation of miR-34a-5p were validated by qPCR +other 32924694 hsa-mir-21 Diabetic Nephropathies Our results demonstrated that knocking out miR-21 ameliorated Nano-Ni-induced pulmonary inflammation, injury, and fibrosis, suggesting the important role of miR-21 in Nano-Ni-induced pulmonary toxicity. +other 32924694 hsa-mir-21 Lung Injury Our results demonstrated that knocking out miR-21 ameliorated Nano-Ni-induced pulmonary inflammation, injury, and fibrosis, suggesting the important role of miR-21 in Nano-Ni-induced pulmonary toxicity. +lncRNA target 32924373 hsa-mir-17 Familial primary gastric lymphoma It has been found that miR-17 can promote the development of gastric lymphoma by regulating HSP60/TNFR2 pathway, which is a potential molecular target for the diagnosis and treatment of gastric lymphoma. +transcription factor target 32924370 hsa-mir-20a Diabetic Nephropathies Sprague-Dawley rats were randomly divided into healthy rat group (H group, n=3), sham group (S group, n=3), sepsis rat group (D group, n=3), sepsis rat negative control transfection group (N group, n=3) and sepsis rat miR-20a inhibitor transfection group (M group, n=3). MiR-20a may cause AKI in sepsis rats via activating autophagy. +transcription factor target 32924370 hsa-mir-20a Sepsis Sprague-Dawley rats were randomly divided into healthy rat group (H group, n=3), sham group (S group, n=3), sepsis rat group (D group, n=3), sepsis rat negative control transfection group (N group, n=3) and sepsis rat miR-20a inhibitor transfection group (M group, n=3). MiR-20a may cause AKI in sepsis rats via activating autophagy. +target gene 32924268 hsa-mir-138 Carcinoma, Hepatocellular And, a potential sequence of AKR1B10P1 transcript was discovered directly interacting with miR-138. SOX4, a pivotal promotor of EMT, was validated as the down-streaming target of miR-138 +target gene 32924237 hsa-mir-95 Pre-Eclampsia MiR-95-5p involved in the migration and invasion of trophoblast cells by targeting LRP6, which might be a potential therapeutic target for PE +other 32923747 hsa-mir-18 COVID-19 Therefore, the antimiR-18 roles were summarized in various primate models that aided in developing the therapy for ACE2 related diseases. +genetics_knock down_promote 32923478 hsa-mir-21 Sepsis Moreover, membrane Nrp-1 expression of TECs was increased significantly during sepsis and Nrp-1 knockdown also mitigated the rise of both the intracellular Ago2 and miR-21a-3p levels in TECs incubated with septic plasma. +target gene 32923135 hsa-mir-200a Melanoma Overexpression of miR-200a-5p reduced TAP1 levels, which was accompanied by a decreased HLA-I surface expression +transcription factor target 32923026 hsa-mir-4668 Eosinophilic Esophagitis We specifically identified miR-4668 as a novel potential biomarker, which was not previously discovered as a target in EoE or any other allergic disease. +circulation_biomarker_diagnosis_up 32922944 hsa-mir-21 Intracranial Aneurysm Significant suppression of serum miRNA-21 in IA patients may provide diagnostic clues for aneurysm rupture and guide clinical intervention. +exosome 32922693 hsa-mir-375 Nijmegen Breakage Syndrome We show that BM metastasis-derived NB-cell lines secrete higher levels of exosomal miR-375, which promotes osteogenic differentiation in MSCs. +exosome 32922693 hsa-mir-375 Osteoporosis Our findings suggest, indeed, a potential role for exosomal miR-375 in determining a favourable microenvironment in BM to promote metastatic progression. +lncRNA target 32922621 hsa-mir-200a Lung Neoplasms These results suggest that in lung carcinomas, higher Akt activation caused by increased AKT2 gene copy number leads to the upregulation of miR-200a, which exerts its function as a suppressor of EphA2 in adenocarcinoma and the early stages of carcinomas. +other 32922589 hsa-mir-28 Atrial Fibrillation circRNAs-hsa-miR-328 network may play a critical role in the pathophysiology and mechanism of AF. +lncRNA target 32922545 hsa-mir-149 Colorectal Neoplasms Conclusion: This study demonstrates that high expression of HOXA11-AS is correlated with CRC progression and poor prognosis and may promote metastasis via EMT by modulating miR +genetics_overexpression_promote 32922520 hsa-mir-29a Carcinoma, Hepatocellular In response to miR-29a-3p overexpression, Robo1 silencing or LINC00473 silencing, HCC cell proliferation, migration, invasion, tumor progression, and metastasis were impeded, which was involved with the inactivation of the PI3K/AKT/mTOR signaling pathway. +other 32922506 hsa-mir-200c Breast Neoplasms CONCLUSIONS: This study implicates that EA11 prevents breast tumor development by interfering with the miR-200c-PDE7B/PD-L1-AKT/MAPK axis. +other 32922169 hsa-mir-143 Dermatitis, Atopic and that rapamycin blocked IL-13-induced down-regulation of miR-143, suppressed the IL-13Ralpha1 expression and up-regulated the expressions of filaggrin, loricrin, and involucrin in HaCaT cells. +circulation_biomarker_diagnosis_ns 32922083 hsa-mir-27b Chordoma In addition, KCNQ1OT1 promoted MDR in chordoma by sponging miR-27b-3p and subsequently increasing ATF2 expression. Our findings demonstrated the role of the KCNQ1OT1/miR-27b-3p/ATF2 axis in MDR of chordoma, which provides new insight into the molecular mechanism of chordoma MDR, and may determine the effect of therapy after receiving chemotherapy by detecting the expression of KCNQ1OT1 in serum. +other 32922080 hsa-mir-138 Squamous Cell Carcinoma of Head and Neck CONCLUSION: In short, our findings provided first evidence that TRPM2-AS is highly expressed and exerts its oncogenic role in LSCC partly by miR-138/SOX4 axis. +target gene 32922078 hsa-mir-1296 Breast Neoplasms Blocking circ_0000520 Suppressed Breast Cancer Cell Growth, Migration and Invasion Partially via miR-1296/SP1 Axis Both in vitro and in vivo. +target gene 32922076 hsa-mir-4516 Breast Neoplasms lncRNA PART1 Promotes Breast Cancer Cell Progression by Directly Targeting miR-4516. +genetics_knock down_promote 32922073 hsa-mir-1182 Carcinoma, Non-Small-Cell Lung In addition, circ_0000376 knockdown inhibited the NSCLC tumor growth via regulating the miR-1182 and NOVA2 expression in vivo. +circRNA target 32922071 hsa-mir-516a Urinary Bladder Neoplasms CONCLUSION: circRNA_103809 promotes proliferation, migration, invasion and chemo-resistance of BC cells through regulating miR-516a-5p/FBXL18 axis. +other 32922043 hsa-mir-153 Carcinoma, Non-Small-Cell Lung CONCLUSION: The HIF1A-AS2/miR5p/S100A14 axis plays a crucial role in promoting NSCLC progression. +other 32922042 hsa-mir-143 Osteosarcoma 3p/ZEB1 axis. +other 32922040 hsa-let-7c Uterine Cervical Neoplasms CONCLUSION: In conclusion, we speculate that the regulation of the hsa_circ_0000069/hsa-miR-125b-5p/CDKN2A and hsa_circ_0020594/hsa-let-7c-5p/CCNB2 axes may be involved in CSCC. +other 32922040 hsa-mir-125b Uterine Cervical Neoplasms CONCLUSION: In conclusion, we speculate that the regulation of the hsa_circ_0000069/hsa-miR-125b-5p/CDKN2A and hsa_circ_0020594/hsa-let-7c-5p/CCNB2 axes may be involved in CSCC. +lncRNA target 32921999 hsa-mir-1 Pulmonary Disease, Chronic Obstructive The interaction relationship between miR-31-5p and LINC00612 or Notch1 was predicted by bioinformatics databases, while dual-luciferase reporter, RNA immunoprecipitation, and RNA pull-down assays were performed to confirm prediction +lncRNA target 32921988 hsa-mir-181a Renal Insufficiency, Chronic PVT1 bound to miR-181a-5p in HK-2 cells. Moreover, miR-181a-5p directly targeted TGF-betaR1 +exosome 32921986 hsa-mir-34a Pancreatic Carcinoma In the present study, we synthesize exosomes-coated miR-34a (exomiR-34a), and the anticancer effect of exomiR-34a was evaluated in pancreatic cancer. +lncRNA target 32921982 hsa-mir-17 Adenomyosis Dual-luciferase reporter (DLR) assay conformed the targeting relation of lncRNA H19/miR-17/TLR4 pathway. CONCLUSION: LNG ameliorates adenomyosis via lncRNA H19/miR-17/TLR4 pathway. +target gene 32921226 hsa-mir-183 Carcinoma, Hepatocellular Insulin receptor substrate 1 (IRS1) is a target of miR-183-5p, and luciferase analysis confirmed that miR-183-5p combines with the 3'-untranslated region (3'-UTR) of IRS1. +other 32921164 hsa-mir-146a Colorectal Neoplasms We showed that hsa-miR-146a-5p expression is inversely proportional to the expression level of SPP1 +tissue_expression_up 32921119 hsa-mir-206 Shock, Septic Serum miR-206 expression is positively correlated with the severity and prognosis of sepsis +other 32920979 hsa-mir-326 Medulloblastoma MiR-326 targets E2F1 mRNA, thereby reducing its protein levels +circulation_biomarker_diagnosis_up 32920929 hsa-mir-190 Pulmonary Embolism The relative expression levels of miRNA-190 and miRNA-197 in PTE patients were significantly higher than in the MI and healthy control groups, +circulation_biomarker_diagnosis_up 32920929 hsa-mir-197 Pulmonary Embolism The relative expression levels of miRNA-190 and miRNA-197 in PTE patients were significantly higher than in the MI and healthy control groups, +lncRNA target 32920922 hsa-mir-17 Uterine Cervical Neoplasms In this study, we have identified 39 long noncoding RNAs as DeltaNp63alpha targets in CSCC through RNA sequencing and chromatin immunoprecipitation sequencing, in which we further confirmed and focused on the two tumor-related long noncoding RNAs, PART1 (lncPART1) and MIR17HG (lncMIR17HG). Examinations of clinical tissues indicated that the expression of lncPART1 was positively correlated with DeltaNp63alpha expression, while lncMIR17HG was negatively correlated with DeltaNp63alpha expression, suggesting that DeltaNp63alpha plays a central role via regulating its direct targets in the progression of CSCC. +lncRNA target 32920731 hsa-mir-223 Osteoporosis FOXO3, targeted by miR +other 32920730 hsa-mir-214 Osteosarcoma Circ-XPR1 regulates OS cell proliferation by sponging miR-214-5p to regulate DDX5 expression +lncRNA target 32920660 hsa-mir-495 Stomach Neoplasms SNHG10 promotes the procession of GC through targeting miR-495-3p/CTNNB1 and activating WNT signaling pathway +lncRNA target 32920509 hsa-mir-656 Nasopharyngeal Carcinoma we showed SNHG8 serves as a sponge for miR-656-3p to regulate SATB1 expression +tissue_expression_down 32920076 hsa-mir-664 Alzheimer Disease The analyses yielded 6 miRNAs differentially expressed +tissue_expression_down 32920076 hsa-mir-365b Alzheimer Disease The analyses yielded 6 miRNAs differentially expressed +tissue_expression_up 32920076 hsa-mir-1202 Alzheimer Disease The analyses yielded 6 miRNAs differentially expressed +tissue_expression_down 32920076 hsa-mir-4449 Alzheimer Disease The analyses yielded 6 miRNAs differentially expressed +tissue_expression_down 32920076 hsa-mir-4286 Alzheimer Disease The analyses yielded 6 miRNAs differentially expressed +lncRNA target 32919956 hsa-mir-335 Urinary Bladder Neoplasms we validated that LncRNA-XIST inhibited miR-335 expressions through acting as RNA sponges +lncRNA target 32919431 hsa-mir-100 Breast Neoplasms Students utilized bioinformatics to predict targets genes of miR-100, a microRNA that is differentially expressed in a cell culture model of breast cancer metastasis. +tissue_expression_down 32919420 hsa-mir-1228 Colonic Neoplasms we have shown that both microRNA-194 and microRNA-1228 alteration was correlated with the presence of advanced colon cancer, +tissue_expression_down 32919420 hsa-mir-194 Colonic Neoplasms we have shown that both microRNA-194 and microRNA-1228 alteration was correlated with the presence of advanced colon cancer +tissue_expression_up 32919404 hsa-mir-19b Depressive Disorder, Major 8 miRNAs (miR-215-5p, miR-192-5p, miR-202-5p, miR-19b-3p, miR-423-5p, miR-219a-2-3p; miR-511-5p, miR-483-5p showed significant (FDR corrected; p < 0.05) differential regulation in the synaptic fraction from dlPFC of MDD subjects +tissue_expression_up 32919404 hsa-mir-202 Depressive Disorder, Major 8 miRNAs (miR-215-5p, miR-192-5p, miR-202-5p, miR-19b-3p, miR-423-5p, miR-219a-2-3p; miR-511-5p, miR-483-5p showed significant (FDR corrected; p < 0.05) differential regulation in the synaptic fraction from dlPFC of MDD subjects +tissue_expression_down 32919404 hsa-mir-483 Depressive Disorder, Major 8 miRNAs (miR-215-5p, miR-192-5p, miR-202-5p, miR-19b-3p, miR-423-5p, miR-219a-2-3p; miR-511-5p, miR-483-5p showed significant (FDR corrected; p < 0.05) differential regulation in the synaptic fraction from dlPFC of MDD subjects +tissue_expression_up 32919404 hsa-mir-219a-2 Depressive Disorder, Major 8 miRNAs (miR-215-5p, miR-192-5p, miR-202-5p, miR-19b-3p, miR-423-5p, miR-219a-2-3p; miR-511-5p, miR-483-5p showed significant (FDR corrected; p < 0.05) differential regulation in the synaptic fraction from dlPFC of MDD subjects +tissue_expression_down 32919404 hsa-mir-511 Depressive Disorder, Major 8 miRNAs (miR-215-5p, miR-192-5p, miR-202-5p, miR-19b-3p, miR-423-5p, miR-219a-2-3p; miR-511-5p, miR-483-5p showed significant (FDR corrected; p < 0.05) differential regulation in the synaptic fraction from dlPFC of MDD subjects +tissue_expression_up 32919404 hsa-mir-215 Depressive Disorder, Major 8 miRNAs (miR-215-5p, miR-192-5p, miR-202-5p, miR-19b-3p, miR-423-5p, miR-219a-2-3p; miR-511-5p, miR-483-5p showed significant (FDR corrected; p < 0.05) differential regulation in the synaptic fraction from dlPFC of MDD subjects +tissue_expression_up 32919404 hsa-mir-423 Depressive Disorder, Major 8 miRNAs (miR-215-5p, miR-192-5p, miR-202-5p, miR-19b-3p, miR-423-5p, miR-219a-2-3p; miR-511-5p, miR-483-5p showed significant (FDR corrected; p < 0.05) differential regulation in the synaptic fraction from dlPFC of MDD subjects +tissue_expression_up 32919404 hsa-mir-192 Depressive Disorder, Major 8 miRNAs (miR-215-5p, miR-192-5p, miR-202-5p, miR-19b-3p, miR-423-5p, miR-219a-2-3p; miR-511-5p, miR-483-5p showed significant (FDR corrected; p < 0.05) differential regulation in the synaptic fraction from dlPFC of MDD subjects +circRNA target 32919302 hsa-mir-141 Prostatic Neoplasms These findings revealed that circCRKL inhibited the progression of PCa through upregulating KLF5 expression by sponging miR-141 +target gene 32919020 hsa-mir-495 Thyroid Cancer, Papillary Variant CAG alleles at these loci significantly enhanced SPARC transcription activation upon cotransfection with miR-29b and miR-495 when compared to the common alleles GGC (all P<0.05). +target gene 32919020 hsa-mir-29b Thyroid Cancer, Papillary Variant CAG alleles at these loci significantly enhanced SPARC transcription activation upon cotransfection with miR-29b and miR-495 when compared to the common alleles GGC (all P<0.05). +transcription factor target 32918915 hsa-mir-214 Heart Failure 5p, miR-31a-5p contribute to heart-failure like behaviour in Ca(2+) handling and electrophysiology and could be potential treatment targets. +other 32918915 hsa-mir-140 Heart Failure "Of the ""exercise-miRNAs"", miR3p prolonged AP duration, whereas miR-140 and miR-208a shortened AP duration." +other 32918915 hsa-mir-208a Heart Failure "Of the ""exercise-miRNAs"", miR3p prolonged AP duration, whereas miR-140 and miR-208a shortened AP duration." +transcription factor target 32918915 hsa-mir-497 Heart Failure 5p, miR-31a-5p contribute to heart-failure like behaviour in Ca(2+) handling and electrophysiology and could be potential treatment targets. +transcription factor target 32918915 hsa-mir-1 Heart Failure 5p, miR-31a-5p contribute to heart-failure like behaviour in Ca(2+) handling and electrophysiology and could be potential treatment targets. +other 32918895 hsa-mir-424 Uterine Cervical Neoplasms KDM5A functions as a tumor activator in cervical cancer pathogenesis by binding to the miR-424-5p promoter and inhibiting its tumor-suppressive function +target gene 32918845 hsa-mir-152 Colorectal Neoplasms TMSB10 was the direct target gene of miR-152-3p +lncRNA target 32918701 hsa-mir-145 Arthritis, Rheumatoid PVT1 can regulate apoptosis and inflammatory responses in RA-FLSs by targeting miR +other 32918541 hsa-mir-486 Ovarian Neoplasms 5p and accelerates ovarian cancer progression. +genetics_knock down_promote 32918539 hsa-mir-433 Glioma MiR-433 directly interacted with HMGB3 mRNA, and HMGB3 overexpression partly counteracted the effects of miR-433 up-regulation in glioma cells. +lncRNA target 32918360 hsa-mir-455 Glioblastoma LncRNA HOXA-AS3 promotes the malignancy of glioblastoma through regulating miR +exosome 32918341 hsa-mir-200c Vitiligo Moreover, the expression of miR-200c, which mediates melanogenesis in exosomes secreted by keratinocytes in vitiligo lesions, is down-regulated, which may be one of the pathogenesis in vitiligo. +other 32918330 hsa-mir-210 Crouzon syndrome-acanthosis nigricans syndrome In the validation set, miR-21, miR-210 and miR-4639 showed the capability to discriminate between subjects with chronic allograft dysfunction (eGFR < 60 mL/min/1.73 m2 ) and those with normal graft function (eGFR > 90 mL/min/1.73 m2 ). +other 32918330 hsa-mir-4639 Crouzon syndrome-acanthosis nigricans syndrome In the validation set, miR-21, miR-210 and miR-4639 showed the capability to discriminate between subjects with chronic allograft dysfunction (eGFR < 60 mL/min/1.73 m2 ) and those with normal graft function (eGFR > 90 mL/min/1.73 m2 ). +other 32918330 hsa-mir-21 Crouzon syndrome-acanthosis nigricans syndrome In the validation set, miR-21, miR-210 and miR-4639 showed the capability to discriminate between subjects with chronic allograft dysfunction (eGFR < 60 mL/min/1.73 m2 ) and those with normal graft function (eGFR > 90 mL/min/1.73 m2 ). +circulation_biomarker_prognosis_up 32917956 hsa-mir-92a Carcinoma, Hepatocellular Clinical data showed that a high plasma exosomal miR92a-3p level was correlated with shortened overall survival and disease-free survival, indicating poor prognosis in HCC patients. +genetics_overexpression_promote 32917949 hsa-mir-144 Polycystic Ovary Syndrome Cell proliferation assays and flow cytometry assay were carried out following the overexpression of miR +other 32917936 hsa-mir-582 Stomach Neoplasms 5p are biomarkers for predicting overall survival, as they were involved in regulating oxaliplatin resistance by altering autophagy in gastric adenocarcinoma. +other 32917852 hsa-mir-1972 Thyroid Cancer, Papillary Mechanistically, DOCK9-AS2 interacted with SP1 to induce catenin beta 1 (CTNNB1) transcription and sponged microRNA-1972 (miR-1972) to upregulate CTNNB1, thereby activating Wnt/beta-catenin pathway in PTC cells. +lncRNA target 32916774 hsa-mir-134 Glioma We concluded that LINC00470 promoted the expression of MYC and ABCC1 by suppressing miR-134, thus promoting glioma cell proliferation and invasion, and attenuating TMZ chemosensitivity. +other 32916773 hsa-mir-1246 Community-Acquired Pneumonia While expression levels of miR-1246 showed significant changes with an increase in overall disease severity from volunteers to CAP and to sepsis, miR-193a-5p and miR3p differentiated patients with an infectious disease (CAP or sepsis) from volunteers. +other 32916773 hsa-mir-193a Community-Acquired Pneumonia While expression levels of miR-1246 showed significant changes with an increase in overall disease severity from volunteers to CAP and to sepsis, miR-193a-5p and miR3p differentiated patients with an infectious disease (CAP or sepsis) from volunteers. +other 32916773 hsa-mir-193a Pneumonia While expression levels of miR-1246 showed significant changes with an increase in overall disease severity from volunteers to CAP and to sepsis, miR-193a-5p and miR3p differentiated patients with an infectious disease (CAP or sepsis) from volunteers. +other 32916773 hsa-mir-542 Pneumonia While expression levels of miR-1246 showed significant changes with an increase in overall disease severity from volunteers to CAP and to sepsis, miR-193a-5p and miR3p differentiated patients with an infectious disease (CAP or sepsis) from volunteers. +other 32916773 hsa-mir-1246 Pneumonia While expression levels of miR-1246 showed significant changes with an increase in overall disease severity from volunteers to CAP and to sepsis, miR-193a-5p and miR3p differentiated patients with an infectious disease (CAP or sepsis) from volunteers. +other 32916773 hsa-mir-542 Community-Acquired Pneumonia While expression levels of miR-1246 showed significant changes with an increase in overall disease severity from volunteers to CAP and to sepsis, miR-193a-5p and miR3p differentiated patients with an infectious disease (CAP or sepsis) from volunteers. +epigenetics 32916600 hsa-mir-200b Glioblastoma Our data indicate that the adenosine methylation of miR-200b-3p is associated with the survival of glioblastoma patients. +genetics_knock down_promote 32916503 hsa-mir-216a Breast Neoplasms MiR-216a-5p inhibition or GLO1 overexpression reversed the effects of OIP5-AS1 knockdown on the development of breast cancer cells. CONCLUSIONS: OIP5-AS1 knockdown suppressed the progression of breast cancer by inducing GLO1 expression via competitively binding to miR-216a-5p, suggesting that OIP5-AS1 was a hopeful biomarker for the therapy of breast cancer. +circulation_biomarker_diagnosis_up 32916448 hsa-mir-139 Squamous Cell Carcinoma of Head and Neck 3p mimic or rab5a-plasmid. +circulation_biomarker_diagnosis_up 32916037 hsa-mir-204 ST Elevation Myocardial Infarction The expressions of NEAT1 and MMP-9 in serum exosomes of patients with acute ST-segment elevation myocardial infarction were up-regulated and positively correlated, miR-204 expression was down-regulated, there were no correlations between miR-204 with NEAT1, or MMP-9. Exosomal NEAT1, miR-204, and MMP-9 displayed potent biomarkers for diagnosis of acute ST-segment elevation myocardial infarction. +lncRNA target 32915648 hsa-mir-4461 Carcinoma, Renal Cell MiR-4461 Inhibits Tumorigenesis of Renal Cell Carcinoma by Targeting PPP1R3C. +lncRNA target 32915416 hsa-mir-338 Autoimmune Diseases of the Nervous System LV in sciatic nerves might improve neuromuscular function in EAN by inhibiting the conversion of Schwann cells into inflammatory cells. +epigenetics 32915372 hsa-mir-124a Stomach Neoplasms DESIGN: Using quantitative MethyLight assay, MOS, miR124a-3, NKX6-1, EMX1, CDH1, and TWIST1 methylation levels in the noncancerous gastric mucosa was compared between subjects with and without FH based on GC and Helicobacter pylori (Hp) infection. In Hp-positive controls, MOS methylation was lower in subjects with FH (n = 73) than in those without FH (n = 50) (P = 0.042), while miR124a-3 (P = 0.006), NKX6-1 (P < 0.001), and CDH1 (P < 0.001) methylation were higher in subjects with FH. +genetics_overexpression_promote 32914707 hsa-mir-184 Carcinoma, Pancreatic Ductal In vitro studies showed that microRNA-184 overexpression induced apoptosis and suppressed cell cycle transition from G1 to S and G2 phases in pancreatic ductal adenocarcinoma cells. +circulation_biomarker_diagnosis_ns 32914665 hsa-mir-148a Colorectal Neoplasms 5p were significantly dysregulated in colorectal cancer serum when compared with healthy controls. +circulation_biomarker_diagnosis_ns 32914665 hsa-mir-34b Colorectal Neoplasms 5p were significantly dysregulated in colorectal cancer serum when compared with healthy controls. +circulation_biomarker_diagnosis_ns 32914665 hsa-mir-146a Colorectal Neoplasms 5p were significantly dysregulated in colorectal cancer serum when compared with healthy controls. +circulation_biomarker_diagnosis_ns 32914665 hsa-mir-1 Colorectal Neoplasms 5p were significantly dysregulated in colorectal cancer serum when compared with healthy controls. +other 32914565 hsa-mir-125a Heart Failure CONCLUSIONS: Our results demonstrate that the common missense variant rs2070600-A allele is associated with a reduced risk of cardiovascular death and cardiac transplantation by facilitating the binding of miR-125a-3p. +other 32914384 hsa-mir-223 Coronary Artery Disease MiR-223 is closely associated with pathogenesis of coronary artery disease (CAD); however, the molecular mechanisms are unclear. +other 32914382 hsa-mir-200 Pulmonary Fibrosis Because of the recent role of miR-200 family and Sonic Hedgehog (SHH) trajectory in IPF, we have studied their impact on the anti-fibrotic potential of tadalafil against bleomycin-induced pulmonary fibrosis. +genetics_overexpression_promote 32914380 hsa-mir-25 Colorectal Neoplasms Therefore, overexpression of miR-325 inhibited the phosphorylation of PI3K and AKT and decreased the expression of Bcl-2 to promote the oxaliplatin-induced mitochondrial apoptosis in colorectal cancer. +target gene 32913892 hsa-mir-24 Pancreatic Neoplasms miR-324-5p Contributes to Cell Proliferation and Apoptosis in Pancreatic Cancer by Targeting KLF3. +circulation_biomarker_prognosis_ns 32913856 hsa-mir-1271 Carcinoma, Hepatocellular Monitoring the levels of serum GPC3 and circulating miR-1271 has importantclinical reference value for evaluating the prognosis of patients with HCC. +circulation_biomarker_prognosis_up 32913852 hsa-mir-208b Atrial Fibrillation CONCLUSION: The serum levels of FGF-23 and miR-208b are increased in patients with atrial fibrillation and are related to the type of disease, cardiac parameters, and prognosis. +genetics_overexpression_promote 32913547 hsa-mir-27a Glioma Regulatory effects of miRNA-27a-3p on phenotypes of TMZ-resistant glioma cells were abolished by overexpression of NF1. +genetics_knock down_promote 32913545 hsa-mir-186 Adenocarcinoma of Lung Furthermore, knockdown of circ_0007142 inhibited the biological behavior of lung adenocarcinoma through miR-186/FOXK1 axis and inactivated the Wnt/beta-catenin signaling pathway. Altogether, our study suggests Circ_0007142/miR-186/FOXK1 axis may play as an important role in progression of lung adenocarcinoma, which provided a novel potential mechanism about this disease. +target gene 32913542 hsa-mir-422a Stomach Neoplasms MiR-422a in gastric cancer cells directly targets CDC40 and modulates cell proliferation. +lncRNA target 32913516 hsa-mir-205 Endometrial Neoplasms We demonstrated for the first time that RP11-395G23.3 may inhibit the development and pathogenesis of EC by acting as a sponge for miRNA +other 32913502 hsa-mir-29a Osteoporosis, Postmenopausal MiR-29a-3p, miR5p, and miR-486 expression decreased in the PMOP group compared to the control group. +other 32913502 hsa-mir-93 Osteoporosis, Postmenopausal MiR-29a-3p, miR5p, and miR-486 expression decreased in the PMOP group compared to the control group. +other 32913502 hsa-mir-486 Osteoporosis, Postmenopausal MiR-29a-3p, miR5p, and miR-486 expression decreased in the PMOP group compared to the control group. +lncRNA target 32913498 hsa-mir-217 Glioma LncRNA-LYPLAL1-2 acted as a sponge molecule and targeted miR-217 in glioma cells. CONCLUSIONS: LncRNA-LYPLAL1-2 suppressed glioma metastasis via the miR-217/YWHAG axis and is expected to be a potential target for early diagnosis and treatment of gliomas. +lncRNA target 32913496 hsa-mir-1236 Prostatic Neoplasms 3p inhibited PCa cells growth and metastasis by activating p21. +transcription factor target 32913477 hsa-mir-182 Glioma In conclusion, we believed that miR-182 modulates glioma cell migration and invasion by targeting the MTSS1 and suggested that miR-182 was a potential therapeutic target for gliomas. +target gene 32913475 hsa-mir-152 Breast Neoplasms EPAS1 targeting by miR-152-3p in Paclitaxel-resistant Breast Cancer. +genetics_overexpression_suppress 32913469 hsa-mir-139 Lung Neoplasms Our conclusion is that overexpression of miR5p can down-regulate the expression of Notch1 and reverse the occurrence of malignant lung events induced by chronic exposure to PM2.5. +genetics_knock down_suppress 32913464 hsa-mir-107 Glioma Moreover, rescue assays reveal that HMGB1 overexpression (or miR-107 inhibition) reverses the glioma growth inhibition caused by LINC00662 knockdown. In conclusion, our results indicate that LINC00662 acts as an oncogene in glioma by modulating the miR-107/HMGB1 axis, suggesting that LINC00662 could be a novel therapeutic target for glioma treatment. +lncRNA target 32913463 hsa-mir-21 Cholangiocarcinoma By analyzing the TCGA dataset, we found that expression of miR-21, an oncogene and a potential target of anticancer drugs for cholangiocarcinoma, was upregulated in cholangiocarcinoma tissues compared to paired control tissues. Taken together, our study demonstrates that dihydromyricetin inhibits cell proliferation, migration, invasion and promotes apoptosis in cholangiocarcinoma cells via regulating miR-21. +lncRNA target 32913459 hsa-mir-6777 Carcinoma, Hepatocellular Conclusion: Our findings indicate that LINC00355:8 activates Wnt10b and promotes HCC progression via the suppression of miR +genetics_GWAS 32913227 hsa-mir-210 Retinal Degeneration Genetic deletion of miR-210 leads to lipid droplet accumulation and photoreceptor degeneration in the retina. +lncRNA target 32913227 hsa-mir-210 Nerve Degeneration In the present study, we provide evidence that the conserved microRNA miR-210 regulates lipid metabolism and prevents neurodegeneration in the Drosophila retina. Reduction of ACS in the miR-210 mutant background suppresses the neurodegeneration defects, suggesting that miR-210 acts through regulation of the ACS transcript. +lncRNA target 32913183 hsa-mir-182 Urinary Bladder Neoplasms 5p-induced inhibition of p27 3'UTR activity. +lncRNA target 32913142 hsa-mir-23b Cataract, Age-Related Notably, the level of circZNF292 was significantly decreased, while miR-23b-3p was significantly increased in ARC. Our results indicate that circZNF292, a down-regulated circRNA in the anterior lens capsule of ARC patients, may be involved in resistance to oxidative damage and apoptosis of lens epithelial cells by sponging miR-23b-3p, providing a potential target for prevention and treatment of ARC. +lncRNA target 32912827 hsa-mir-21 Fibrosis, Renal The ability of FZHY to modulate miR-21/PTEN/AKT signaling may be a viable approach for treating RIF. +lncRNA target 32912499 hsa-mir-153 Brain Injuries CONCLUSIONS: Our results indicate that LncRNA-KCNQ1OT1 promotes OGD/R-induced neuronal injury at least partially through acting as a competing endogenous RNA (ceRNA) for miR3p to regulate Foxo3a expression, suggesting LncRNA-KCNQ1OT1 as a potential therapeutic target for cerebral I/R injury. +lncRNA target 32912499 hsa-mir-153 Brain Ischemia CONCLUSIONS: Our results indicate that LncRNA-KCNQ1OT1 promotes OGD/R-induced neuronal injury at least partially through acting as a competing endogenous RNA (ceRNA) for miR3p to regulate Foxo3a expression, suggesting LncRNA-KCNQ1OT1 as a potential therapeutic target for cerebral I/R injury. +circulation_biomarker_prognosis_ns 32912406 hsa-mir-126 Sepsis CONCLUSIONS: miR-126 in peripheral blood lymphocytes of patients with sepsis may affect immune status by promoting apoptosis of lymphocytes, and its expression level can reflect the severity and prognosis of sepsis. +lncRNA target 32912324 hsa-mir-182 Chromate Resistance Thus, SNHG14/miR5p/BINP3 axis may be a valuable target for CI/R injury therapies. +lncRNA target 32912324 hsa-mir-182 Reinjuries Thus, SNHG14/miR5p/BINP3 axis may be a valuable target for CI/R injury therapies. +lncRNA target 32912324 hsa-mir-182 Osteoarthropathy, Primary Hypertrophic Thus, SNHG14/miR5p/BINP3 axis may be a valuable target for CI/R injury therapies. +other 32912198 hsa-mir-29b Netherton Syndrome 3p, hsa-miR-30a-5p and hsa-let-7i-5p. +other 32912198 hsa-mir-143 Netherton Syndrome 3p, hsa-miR-30a-5p and hsa-let-7i-5p. +other 32912198 hsa-mir-423 Netherton Syndrome 3p, hsa-miR-365a-3p, and hsa-miR-365b-3p), which are not expressed in other three groups. +other 32912198 hsa-mir-224 Netherton Syndrome 3p, hsa-miR-365a-3p, and hsa-miR-365b-3p), which are not expressed in other three groups. +other 32912198 hsa-let-7i Netherton Syndrome 3p, hsa-miR-30a-5p and hsa-let-7i-5p. +other 32912198 hsa-let-7f Netherton Syndrome 3p, hsa-miR-30a-5p and hsa-let-7i-5p. +other 32912198 hsa-mir-365a Netherton Syndrome 3p, hsa-miR-365a-3p, and hsa-miR-365b-3p), which are not expressed in other three groups. +other 32912198 hsa-mir-365b Netherton Syndrome 3p, hsa-miR-365a-3p, and hsa-miR-365b-3p), which are not expressed in other three groups. +other 32912198 hsa-let-7a Netherton Syndrome Among them has-let-7a-5p has high sensitivity and specificity to distinguish NS with the rest of the users, using ROC curve analysis. +other 32912198 hsa-mir-193b Netherton Syndrome 3p, hsa-miR-365a-3p, and hsa-miR-365b-3p), which are not expressed in other three groups. +other 32912198 hsa-mir-21 Netherton Syndrome 3p, hsa-miR-30a-5p and hsa-let-7i-5p. +lncRNA target 32912113 hsa-mir-887 Carcinoma, Hepatocellular CONCLUSION: The upregulation of miR-887 could facilitate the proliferation and metastasis of hepatocellular carcinoma cells via targeting VHL. +other 32911872 hsa-mir-133a Myocardial Infarction MicroRNAs (miRNAs/miRs) such as miR-1, miR-133a, miR-133b, miR-135a, and miR-29b play a key role in many cardiac pathological remodeling processes, including apoptosis, fibrosis, and arrhythmias, after a myocardial infarction (MI). +other 32911872 hsa-mir-29b Myocardial Infarction MicroRNAs (miRNAs/miRs) such as miR-1, miR-133a, miR-133b, miR-135a, and miR-29b play a key role in many cardiac pathological remodeling processes, including apoptosis, fibrosis, and arrhythmias, after a myocardial infarction (MI). +other 32911872 hsa-mir-135a Myocardial Infarction MicroRNAs (miRNAs/miRs) such as miR-1, miR-133a, miR-133b, miR-135a, and miR-29b play a key role in many cardiac pathological remodeling processes, including apoptosis, fibrosis, and arrhythmias, after a myocardial infarction (MI). +other 32911872 hsa-mir-1 Myocardial Infarction MicroRNAs (miRNAs/miRs) such as miR-1, miR-133a, miR-133b, miR-135a, and miR-29b play a key role in many cardiac pathological remodeling processes, including apoptosis, fibrosis, and arrhythmias, after a myocardial infarction (MI). +other 32911872 hsa-mir-133b Myocardial Infarction MicroRNAs (miRNAs/miRs) such as miR-1, miR-133a, miR-133b, miR-135a, and miR-29b play a key role in many cardiac pathological remodeling processes, including apoptosis, fibrosis, and arrhythmias, after a myocardial infarction (MI). +transcription factor target 32911741 hsa-mir-100 Head and Neck Neoplasms 3p targeting STK11 in HNC. +circRNA target 32911346 hsa-mir-30 Carcinoma, Non-Small-Cell Lung Our results reveal that circRNA_102179 facilitates the proliferation, migration, and invasion of NSCLC cell via modulating miR +lncRNA target 32911332 hsa-mir-607 Breast Neoplasms IRE1-dependent degradation of tumor suppressor miR-3607 leads to elevation of RAS oncogene GTPase RAB3B in breast cancer cells. +transcription factor target 32911091 hsa-mir-155 Liver Cirrhosis Herein, a novel fluoropolymer is developed to achieve high drug loading of sorafenib and efficient delivery of miR155 inhibitor (anti-miR155) for dual-targeting of hepatic stellate cells (HSCs) and kupffer cells (KCs), and we report a detailed plan on the design of treatment regimen to reveal the relationship between chemogene therapy, intervention time and fibrosis recurrence. +other 32911026 hsa-mir-335 Femur Head Necrosis Our previous study demonstrated that upregulated miR-335 in bone microvascular endothelial cells (BMECs) might be associated with the disease of steroid-induced ONFH. ICA regulated the imbalance of miRNA-335 expression induced by the glucocorticoid in BMECs, which provides a new viewpoint to explore the mechanism of ICA in preventing steroid-induced ONFH. +other 32910981 hsa-mir-20a Parkinsonian Disorders Four urinary microRNAs (miR-191, miR-19b, miR-20a and miR-30b) had good diagnostic performance (AUC greater than 0.8) to predict AKIN2/3 between 4-8 hours post ingestion. +other 32910981 hsa-mir-191 Parkinsonian Disorders Four urinary microRNAs (miR-191, miR-19b, miR-20a and miR-30b) had good diagnostic performance (AUC greater than 0.8) to predict AKIN2/3 between 4-8 hours post ingestion. +other 32910981 hsa-mir-20a Acute Kidney Injury Four urinary microRNAs (miR-191, miR-19b, miR-20a and miR-30b) had good diagnostic performance (AUC greater than 0.8) to predict AKIN2/3 between 4-8 hours post ingestion. +other 32910981 hsa-mir-191 Acute Kidney Injury Four urinary microRNAs (miR-191, miR-19b, miR-20a and miR-30b) had good diagnostic performance (AUC greater than 0.8) to predict AKIN2/3 between 4-8 hours post ingestion. +other 32910981 hsa-mir-19b Parkinsonian Disorders Four urinary microRNAs (miR-191, miR-19b, miR-20a and miR-30b) had good diagnostic performance (AUC greater than 0.8) to predict AKIN2/3 between 4-8 hours post ingestion. +other 32910981 hsa-mir-19b Acute Kidney Injury Four urinary microRNAs (miR-191, miR-19b, miR-20a and miR-30b) had good diagnostic performance (AUC greater than 0.8) to predict AKIN2/3 between 4-8 hours post ingestion. +other 32910787 hsa-mir-421 Thyroid Cancer, Papillary PTC patient tissues and cell lines showed high ROCK1 mRNA and protein levels as well as low miR-421 levels. These findings demonstrate that DLEU1 promotes PTC progression by sponging miR-421 and increasing ROCK1 expression. +lncRNA target 32910747 hsa-mir-7 Carcinoma, Hepatocellular 5p inhibitor reversed the inhibition effect of silencing lncRNA RHPN1-AS1 on HCCLM3 cells proliferation, migration and invasion. +genetics_knock down_promote 32910719 hsa-mir-7k Colitis phenylindole; DSS: dextran sulfate sodium; GFP: green fluorescent protein; HAI: histological activity index; IFNG/IFN-: interferon gamma; IL10: interleukin 10; IL1RN/IL-1Rra: interleukin 1 receptor antagonist; KD: knockdown; miRNA: microRNA; MSCs: mesenchymal stem cells; MSCT: mesenchymal stem cell transplantation; NTA: nanoparticle tracking analysis; PGE2: prostaglandin E2; SD: standard deviation; siRNA: small-interfering RNA; STAT3: signal transducer and activator of transcription 3; TEM: transmission electron microscopy; TGFB1/TGF-1: transforming growth factor, beta 1; Th17 cell: T helper cell 17; TNF/TNF-: tumor necrosis factor; TNFAIP6/TSG6: tumor necrosis factor alpha induced protein 6; Tregs: regulatory T cells. +lncRNA target 32910484 hsa-mir-214 Diabetes Mellitus Our results indicate that melatonin exhibits a neuroprotective effect by inhibiting neuronal pyroptosis and excessive autophagy through modulating the miR +other 32910167 hsa-mir-137 Schizophrenia These findings suggest that the MIR137 VNTR4 may impact neuroanatomical development that may, in turn, influence the expression of more severe cognitive symptoms in patients with schizophrenia. +other 32910145 hsa-mir-125a Arthritis, Rheumatoid 3p, -4436b-5p) were identified in NARAPs. +other 32910145 hsa-mir-187 Arthritis, Rheumatoid 3p, -4436b-5p) were identified in NARAPs. +lncRNA target 32910126 hsa-mir-196 Selenium Deficiency 5p and NFkappaBIA in chickens, revealing that Se deficiency causes respiratory mucosal immune dysfunction via the miR +circulation_biomarker_diagnosis_ns 32909851 hsa-mir-155 Pre-Eclampsia Serum levels of miR-155 could predict the diagnosis of PE by receiver operating characteristic curve analysis and diagnosis evaluation tests. +genetics_overexpression_suppress 32909490 hsa-mir-15a Peritoneal Fibrosis Overexpression of miR-15a-5p or inhibition of VEGFR could reverse PF. +other 32909217 hsa-mir-125b Mycosis Fungoides 3p) were detected in the MT as well as in MFG and MECs. +other 32909217 hsa-mir-141 Mycosis Fungoides 3p) were detected in the MT as well as in MFG and MECs. +other 32909217 hsa-mir-204 Mycosis Fungoides 5p, chosen on the basis of their abundance in the MT, were quantified using RT-qPCR in lactating cow MT, MFG, and laser capture-microdissected MECs. +lncRNA target 32909217 hsa-mir-126 Mycosis Fungoides 3p was detected both in the MT and in MECs but not in MFG, suggesting a targeting mechanism for miRNAs in MECs. +other 32908925 hsa-mir-499a Angina, Unstable miR-499a-3p may become a candidate biomarker for the diagnosis of unstable angina pectoris (UA). +other 32908925 hsa-mir-499a Urologic Diseases miR-499a-3p may become a candidate biomarker for the diagnosis of unstable angina pectoris (UA). +other 32908925 hsa-mir-499a Angelman Syndrome These results combined suggested that miR-499a-3p may affect the proliferation, migration, and apoptosis of endothelial cells and regulate AS by regulating ADAM10. +circulation_biomarker_diagnosis_up 32908896 hsa-mir-451a Colorectal Neoplasms CONCLUSION: The miR-451a is a potential circulating biomarker for early CRC diagnosis. +transcription factor target 32908879 hsa-mir-150 Cardiomyopathies 5p can alleviate apoptosis and may be a novel therapeutic target for sepsis-induced myocardial depression. +genetics_knock down_promote 32908786 hsa-mir-203 Triple Negative Breast Neoplasms Moreover, TNBC cell proliferation was promoted by DLG1-AS1 overexpression and inhibited by miR-203 overexpression. +genetics_overexpression_promote 32908568 hsa-mir-17 Alzheimer Disease AD and the ERK1/2 inhibitor U0126 (10 mumol/L) inhibited VSMC proliferation and reduced the overexpression of miR-17 approximately 92a. AD inhibits ox-LDL-induced VSMC proliferation via inhibiting ERK1/2 and miR-17 approximately 92a activation. +other 32908453 hsa-mir-338 Colorectal Neoplasms circRAE1 promotes colorectal cancer cell migration and invasion by modulating miR-338-3p/TYRO3 axis. +lncRNA target 32908449 hsa-mir-155 Arthritis, Rheumatoid In conclusion, miRNA-155 participates in the expression of LSD1 and proinflammatory cytokines in rheumatoid synovial cells. +transcription factor target 32908121 hsa-mir-210 Triple Negative Breast Neoplasms Through an integrated analysis and functional verification, we reported that several miRNAs significantly correlates to the Warburg effect in TNBC, including miR +lncRNA target 32907982 hsa-mir-221 Darier Disease 3p and ssc-miR-222, could inhibit the infection and replication of AIV in PAM cells by directly targeting viral genome and inducing cell apoptosis via inhibiting the expression of anti-apoptotic protein HMBOX1. +lncRNA target 32907982 hsa-mir-221 Swine Diseases Avian but not swine influenza virus caused upregulated expressions of ssc-miR +genetics_knock down_promote 32907860 hsa-mir-290 Tourette Syndrome Loss of miR-290 cluster members or gain in miR-322 cluster members led to differentiation of TS cells. The trophoblast stemness factor, CDX2, transactivated the miR-290 cluster and Cyclin D1 MiR-290 cluster members repressed cell cycle repressors, P21, P27, WEE1, RBL2, and E2F7, in TS cells. +transcription factor target 32907715 hsa-mir-1 Coronary Artery Disease 3p induced by UV was correlated with CAD severity, which played an important role in regulating keratinocytes permeability barrier through targeting CLDN1. +circRNA target 32907351 hsa-mir-338 Carcinoma, Hepatocellular Conclusion: CircFBLIM1 facilitated HCC progression and glycolysis via modulating the miR-338/LRP6 axis, which may provide promising therapeutic targets for HCC. +genetics_knock down_promote 32907349 hsa-mir-10b Colorectal Neoplasms Besides, MiR-10b-5p knockdown and matrine treatment repressed CRC growth in vivo. +genetics_knock down_promote 32907346 hsa-mir-520f Cholangiocarcinoma Conclusion: These data confirmed the knockdown SNHG20 expression in CCA could inhibit the proliferation by means of sponging miR-520f-3p. +transcription factor target 32907315 hsa-mir-125b Myocardial Infarction, Acute Sprague-Dawley rats were used for AMI modeling, and the expression of miR-125b in the myocardial tissues of AMI rats was detected via fluorescence quantitative reverse transcription-polymerase chain reaction (qRT-PCR). The expression of miR-125b in the cardiac tissues was decreased in theAMI group compared with that in the Sham group (p<0.05). +lncRNA target 32907305 hsa-mir-92a Stomach Neoplasms Altogether, our findings demonstrated that miR-92a-3p promoted the proliferation and invasion of GC cells by targeting KLF2. +other 32906114 hsa-mir-548k Ischemic Stroke Interestingly, hsa-miR-206, hsa-miR-4491, hsa-miR-3622b-5p, hsa-miR-548k, hsa-miR-302a-3p, hsa-miR3p, KLF12, and ID3 had the potential diagnostic value of ischemic stroke. +other 32906114 hsa-mir-622 Ischemic Stroke Interestingly, hsa-miR-206, hsa-miR-4491, hsa-miR-3622b-5p, hsa-miR-548k, hsa-miR-302a-3p, hsa-miR3p, KLF12, and ID3 had the potential diagnostic value of ischemic stroke. +other 32906114 hsa-mir-4491 Ischemic Stroke Interestingly, hsa-miR-206, hsa-miR-4491, hsa-miR-3622b-5p, hsa-miR-548k, hsa-miR-302a-3p, hsa-miR3p, KLF12, and ID3 had the potential diagnostic value of ischemic stroke. +other 32906114 hsa-mir-206 Ischemic Stroke Interestingly, hsa-miR-206, hsa-miR-4491, hsa-miR-3622b-5p, hsa-miR-548k, hsa-miR-302a-3p, hsa-miR3p, KLF12, and ID3 had the potential diagnostic value of ischemic stroke. +other 32906114 hsa-mir-145 Ischemic Stroke Interestingly, hsa-miR-206, hsa-miR-4491, hsa-miR-3622b-5p, hsa-miR-548k, hsa-miR-302a-3p, hsa-miR3p, KLF12, and ID3 had the potential diagnostic value of ischemic stroke. +other 32905904 hsa-mir-140 Trichohepatoenteric Syndrome 5p) in piglet diarrhea caused by C. +lncRNA target 32905814 hsa-mir-590 Esophageal Squamous Cell Carcinoma 3p on APOBEC3G expression and identifies potential biomarkers or therapeutic targets to improve ESCC treatment outcomes. +lncRNA target 32905431 hsa-mir-18b Diabetic Nephropathies CONCLUSION: KCNQ1OT1 regulated DN cells proliferation, apoptosis and fibrosis via KCNQ1OT1/miR-18b-5p/SORBS2 axis and NF-kB pathway. +genetics_overexpression_suppress 32905397 hsa-mir-1343 Glioma 3p inhibitor and ANXA11 overexpression offset the inhibitory impacts of EIF3J-AS1 silencing on glioma development. +circulation_biomarker_diagnosis_ns 32904998 hsa-mir-326 Arthritis, Rheumatoid The aim of the present study was to investigate the expression of microRNA (miR)-495 and miR-326 in the peripheral blood of patients with rheumatoid arthritis (RA). +other 32904700 hsa-mir-148a Esophageal Squamous Cell Carcinoma miR-148a Regulates the Stem Cell-Like Side Populations Distribution by Affecting the Expression of ACVR1 in Esophageal Squamous Cell Carcinoma. +lncRNA target 32904674 hsa-mir-200a Retinoblastoma CONCLUSION: Inhibition of XIST expression can up-regulate miR-200a-3p-mediated PI3K-Akt/MAPK-ERK signaling pathway and affect cell EMT, proliferation, invasion, and apoptosis, which is expected to be a potential therapeutic target for Rb. +genetics_overexpression_promote 32904666 hsa-mir-381 Carcinoma, Endometrioid Overexpression of miR +genetics_knock down_promote 32904604 hsa-mir-29a Carcinoma, Hepatocellular In rescue experiments, miR-29a had the potential to eliminate the inhibitory effect of circMYLK knockdown in HCC. +circRNA target 32904557 hsa-mir-346 Prostatic Neoplasms Overall, our findings indicated that the circDDX17/miR-346/LHPP pathway inhibited the progression of prostate cancer and that circDDX17 may be a new potential therapeutic or diagnostic target for treating and diagnosing prostate cancer. +genetics_overexpression_suppress 32904490 hsa-mir-17 Prostatic Neoplasms, Castration-Resistant The results showed that cir-ITCH overexpression significantly inhibits the proliferation, migration, and invasion of human PCa cells and that reciprocal inhibition of expression occurred between cir-ITCH and miR-17. +lncRNA target 32904464 hsa-mir-152 Cardiomyopathies In summary, circHIPK3 plays a pivotal role in the development of cardiac fibrosis by targeting the miR3p/TGF-beta2 axis. +genetics_overexpression_promote 32904436 hsa-mir-506 Neuroblastoma 3p restoration also inhibited NB cell malignant behaviors, and STAT2 overexpression partially abolished the role of miR +target gene 32904410 hsa-mir-421 Colorectal Neoplasms MicroRNA-421 Inhibits Apoptosis by Downregulating Caspase-3 in Human Colorectal Cancer. +lncRNA target 32904350 hsa-mir-410 Carcinoma, Non-Small-Cell Lung DISCUSSION: Thus, these results indicated that LINC00680 was cancerogenic in NSCLC by upregulating HMGB1 via sponging miR +target gene 32903925 hsa-mir-125b Pancreatic Neoplasms Anti-Proliferative and Apoptosis-Promoting Effect of microRNA-125b on Pancreatic Cancer by Targeting NEDD9 via PI3K/AKT Signaling. +transcription factor target 32903818 hsa-mir-194 Breast Neoplasms 3p suppresses BC cell proliferation, migration, and invasion by targeting AQP1, providing a novel insight into BC tumorigenesis and treatment. +lncRNA target 32903604 hsa-mir-34a Lung Injury MiR-34a inhibition had a potential to alleviate sepsis-induced lung injury. +lncRNA target 32903604 hsa-mir-34a Sepsis MiR-34a inhibition had a potential to alleviate sepsis-induced lung injury. +lncRNA target 32903535 hsa-mir-370 Breast Neoplasms Our findings suggest that pseudogene HLA-DPB2 can upregulate HLA-DPB1 through sponging has-miR3p, thus exerting its antitumor effect by recruiting tumor-infiltrating immune cells into the breast tumor microenvironment, and that targeting the HLA-DPB2/HLA-DPB1 axis with ICIs may optimize the current immunotherapy for BC. +lncRNA target 32903519 hsa-mir-155 Breast Neoplasms 5p might be useful in predicting response to PARP1 inhibitors in the clinical setting. +lncRNA target 32903414 hsa-mir-215 Adenocarcinoma of Lung 3p expression, thereby regulating the target genes leptin and SLC2A5 and the signaling pathways, taking part in the lnc-REG3G +genetics_knock down_suppress 32903337 hsa-mir-145 Carcinoma, Hepatocellular 5p enhanced sorafenib resistance and metastasis of HCC, and these effects could be attenuated by knockdown of HDAC11. +exosome 32903213 hsa-mir-15a esophagus adenocarcinoma Interestingly, sera expression levels of exosomal miR-15a, -16, and -193a-3p were significantly down regulated in BE PD-L1(+) patients; Sera exosomal miR-15a, -15b, -16, and -193a-3p expression levels in EAC PD-L1(+) patients were significantly lower (all p < 0.01) when compared to EAC PD-L1(-) patients. More importantly, the BE-EAC group had longitudinally decreased exosomal expression levels of miR-15a, -15b, -16, and -193a-3p from BE status to their EAC progression. +other 32902825 hsa-mir-9 Uterine Cervical Neoplasms 5p to regulate SDC2 expression and, thereby, to promote CC tumor development. +lncRNA target 32902737 hsa-mir-4488 Amyotrophic Lateral Sclerosis Protective effects of the combined treatment on vECs against ALSS-induced damage were abolished by the application of miR-4488 inhibitor. +target gene 32902720 hsa-mir-548c Breast Neoplasms MiR-548c-3p inhibits the proliferation, migration and invasion of human breast cancer cell by targeting E2F3. +genetics_overexpression_promote 32902711 hsa-mir-133a Intracranial Aneurysm Our study suggests that overexpression of miR-133a-3p or downregulation of PSAT1 restrains endothelial cell damage and advances endothelial cell proliferation via inhibiting the GSK3beta/beta-catenin pathway in IA. +genetics_overexpression_promote 32902370 hsa-mir-142 Zika Virus Infection Overexpression of miR +genetics_knock down_promote 32902234 hsa-mir-153 Osteoarthritis, Knee 3p may be a useful biomarker and therapeutic target in patients with KOA. +circulation_biomarker_diagnosis_ns 32902214 hsa-mir-17 Breast Neoplasms CONCLUSIONS: In conclusion, our findings strongly suggested that serum exosomal miR +circulation_biomarker_prognosis_up 32902212 hsa-mir-1207 Colorectal Neoplasms CONCLUSIONS: Significant down-regulation of plasma miR +genetics_overexpression_promote 32902157 hsa-mir-101 Lung Neoplasms NSCLC profile and in vitro luciferase analysis results suggested that CERS6 overexpression is promoted, at least in part, by reduced miR-101 expression. +lncRNA target 32902145 hsa-mir-5188 Glioma Our investigation demonstrates that miR-5188 could function as a tumour promoter by directly targeting FOXO1 and participating in SP1-mediated promotion of cell growth and tumorigenesis in glioma. +other 32901892 hsa-mir-183 Brain Ischemia miR-183-5p attenuates cerebral ischemia injury by negatively regulating PTEN. +genetics_overexpression_promote 32901890 hsa-mir-485 Colorectal Neoplasms miR4855p overexpressionmediated malignant properties of CRC cells were partly reversed by the transfection with the CKS1B overexpression plasmid. +transcription factor target 32901887 hsa-mir-25 Intervertebral Disc Degeneration These findings suggested that miR253p may be a novel therapeutic target for IDD prevention. +lncRNA target 32901883 hsa-mir-4722 Colorectal Neoplasms Long noncoding RNA RP11400N13.3 promotes the progression of colorectal cancer by regulating the miR47223p/P2RY8 axis. In conclusion, our results revealed that RP11400N13.3 promoted colorectal cancer progression via modulating the miR47223p/P2RY8 axis, thus suggesting RP11400N13.3 as a potential therapeutic target for the treatment of colorectal cancer. +genetics_overexpression_promote 32901882 hsa-mir-216a Esophageal Squamous Cell Carcinoma Meanwhile, KIAA0101 promoted ESCC migration and invasion, and its overexpression abolished the antitumor effects of miR216a5p mimics. +lncRNA target 32901872 hsa-mir-181b Colonic Neoplasms The aforementioned results indicated that miR181b downregulation inhibited human colon cancer cell proliferation by targeting CYLD to attenuate the activity of the NFkappaB signaling pathway. +lncRNA target 32901872 hsa-mir-181 Colonic Neoplasms The aforementioned results indicated that miR181b downregulation inhibited human colon cancer cell proliferation by targeting CYLD to attenuate the activity of the NFkappaB signaling pathway. +lncRNA target 32901868 hsa-mir-101b Diabetic Nephropathies In conclusion, the present study investigated the circRNA_0000491/miR101b/TGFbetaRI axis in ECM accumulation and fibrosisassociated protein expression levels of mesangial cells, which suggested that circRNA_0000491 may be beneficial for the development of an effective therapeutic target for DN. +genetics_knock down_promote 32901864 hsa-mir-1225 Prostatic Neoplasms In addition, the data of the present study suggested that miR663a and mfiR12255p were upregulated in prostate cancer tissues and cell proliferation of miR663a and miR12255p knockout PCa cells was significantly lower compared with miRNC cells. +genetics_knock down_promote 32901864 hsa-mir-663a Prostatic Neoplasms In addition, the data of the present study suggested that miR663a and mfiR12255p were upregulated in prostate cancer tissues and cell proliferation of miR663a and miR12255p knockout PCa cells was significantly lower compared with miRNC cells. +lncRNA target 32901863 hsa-mir-21 Osteosarcoma In addition, we further verified that phosphatase and tensin homolog (PTEN), a tumor suppressor gene, is the functional target of miR21 and Pice blocks the PTEN/AKT signaling pathway through inhibiting miR21 expression in OS cells. +lncRNA target 32901858 hsa-mir-506 Carcinoma, Hepatocellular RTqPCR revealed that HOXA11AS expression was increased, while that of miR5063p was decreased in HCC tissues and cells compared with that in adjacent nontumor tissues and normal hepatic cells. Taken together, the present study demonstrates that HOXA11AS functions as an oncogene to promote the progression of HCC via the miR5063p/Slug axis, providing a therapeutic target for patients with HCC. +circulation_biomarker_prognosis_up 32901857 hsa-mir-1273a Carcinoma, Non-Small-Cell Lung Furthermore, decreased plasma exosomal miR1273a and increased plasma SDCBP levels were found to be associated with worse therapeutic outcomes of patients with advanced NSCLC receiving platinumbased chemotherapy. +lncRNA target 32901854 hsa-mir-27a Cystadenocarcinoma, Serous, Ovarian Furthermore, micro (mi)RNA27a3p (miR27a3p) was revealed to be increased in HGSOC, and dualluciferase reporter assay indicated that miR27a3p was functioned as a negative regulator of FBLN5 by directly binding with its 3'untranslated region. We hypothesized that FBLN5 was targeted by miR27a3p and may serve as a biomarker and provide a new therapeutic approach for the treatment of HGSOC. +lncRNA target 32901852 hsa-mir-195 Esophageal Squamous Cell Carcinoma A previous study reported that cell division cycle 42 (CDC42) can serve as a target gene of miR195 and mediate malignant progression of esophageal squamous cell carcinoma (ESCC). +lncRNA target 32901852 hsa-mir-195 Esophageal Neoplasms A previous study reported that cell division cycle 42 (CDC42) can serve as a target gene of miR195 and mediate malignant progression of esophageal squamous cell carcinoma (ESCC). +genetics_knock down_promote 32901852 hsa-mir-195 Carcinoma, Ovarian Epithelial Human EOC cell lines OVCA420, OVCAR3, A2780 and SKOV3 cell lines were used to assess the expression and function of miR195, CDC42 and CCND1 in vitro. +transcription factor target 32901848 hsa-mir-155 Cardiomyopathies H9C2 rat cardiomyocytes were cultured with high glucose (HG; 30 mM) to establish an in vitro cardiac fibrosis model that mimicked diabetic conditions; a miR155 inhibitor and a miR155 mimic were transfected into H9C2 cells. In conclusion, the miR155 inhibitor may ameliorate diabetic cardiac fibrosis by reducing the accumulation of oxidative stressrelated molecules, and preventing mitochondrial damage and cardiomyocyte apoptosis by enhancing the Nrf2/HO1 signaling pathway. +other 32901847 hsa-mir-200c Carcinoma, Renal Cell In conclusion, the results of the present study suggested that the SNHG12/miR200c5p/COL11A1 axis may be crucial for RCC progression, which provided an insight into potential therapeutic strategies for RCC treatment. +lncRNA target 32901841 hsa-mir-1236 Retinoblastoma lncRNA FEZF1AS1 promotes migration, invasion and epithelialmesenchymal transition of retinoblastoma cells by targeting miR12363p. In conclusion, the findings of the present study suggested that lncRNAFEZF1AS1 may promote the viability, migration, invasion and EMT of Rb cells by modulating miR12363p. +genetics_knock down_promote 32901838 hsa-mir-34a Carcinoma, Non-Small-Cell Lung miR34a5p was identified as a target for TP73AS1, and its inhibition reversed the effects of TP73AS1 knockdown on NSCLC cells. +circulation_biomarker_diagnosis_ns 32901835 hsa-mir-124 Thyroid Nodule Reverse transcriptionquantitative PCR and western blot analyses were performed to compare the levels of long noncoding RNA nuclear enriched abundant transcript 1 (NEAT1), microRNA (miR)9, miR124, PTEN and programmed cell death protein 6 (PDCD6) in the peripheral blood and thyroid tissue samples between patients with malignant and benign thyroid nodules. +lncRNA target 32901506 hsa-mir-96 Alzheimer Disease 5p in AD via regulating Foxo1. +lncRNA target 32901357 hsa-mir-214 Carcinoma, Hepatocellular Hence, the results propose that miR-214 can prevent HCC development by suppressing beta-catenin and may supply a newfound approach towards HCC therapy in humans. +lncRNA target 32901049 hsa-mir-10b Ovarian Neoplasms Our results support a novel role of lncRNA CHRF in cisplatin resistance of OC and establish CHRF-miR-10b signaling as a putative therapeutic target for sensitizing resistant OC cells. +other 32900348 hsa-mir-150 Acquired Immunodeficiency Syndrome METHODS: The expression level of miR-29, miR-149, miR-199, miR-let7, miR-223, miR-155, miR-122, and miR-150 was evaluated in 20 HIV, 20 HCV, 20 co-infected patients, and 20 healthy controls using real-time PCR assay. +other 32900348 hsa-let-7 Acquired Immunodeficiency Syndrome METHODS: The expression level of miR-29, miR-149, miR-199, miR-let7, miR-223, miR-155, miR-122, and miR-150 was evaluated in 20 HIV, 20 HCV, 20 co-infected patients, and 20 healthy controls using real-time PCR assay. +other 32900348 hsa-mir-199 Acquired Immunodeficiency Syndrome METHODS: The expression level of miR-29, miR-149, miR-199, miR-let7, miR-223, miR-155, miR-122, and miR-150 was evaluated in 20 HIV, 20 HCV, 20 co-infected patients, and 20 healthy controls using real-time PCR assay. +other 32900348 hsa-mir-155 Acquired Immunodeficiency Syndrome METHODS: The expression level of miR-29, miR-149, miR-199, miR-let7, miR-223, miR-155, miR-122, and miR-150 was evaluated in 20 HIV, 20 HCV, 20 co-infected patients, and 20 healthy controls using real-time PCR assay. Also, miR-155 was positively correlated with HCV load. +other 32900348 hsa-mir-223 Acquired Immunodeficiency Syndrome METHODS: The expression level of miR-29, miR-149, miR-199, miR-let7, miR-223, miR-155, miR-122, and miR-150 was evaluated in 20 HIV, 20 HCV, 20 co-infected patients, and 20 healthy controls using real-time PCR assay. +transcription factor target 32900248 hsa-mir-221 Nerve Degeneration CONCLUSIONS: Sevoflurane can cause nerve cell injury, and miR3p may promote cell activity and inhibit apoptosis by inhibiting CDKN1B expression, thereby ameliorating cell injury induced by sevoflurane. +lncRNA target 32900244 hsa-mir-206 Squamous Cell Carcinoma of Head and Neck The study herein aimed to elucidate the effect of miR-206 on HNSCC by targeting STC2. In this study, we investigated the antioncogenic effect of miR-206 on HNSCC by targeting STC2, and highlighted miR-206/STC2 aixs as potential therapeutic targets for HNSCC. +circulation_biomarker_diagnosis_down 32899973 hsa-mir-29 Neuroendocrine Tumors CONCLUSION: Our data suggest a role for miR-29b serum levels as a previously unrecognized biomarker for diagnosis of NET. +circulation_biomarker_diagnosis_down 32899973 hsa-mir-29b Neuroendocrine Tumors CONCLUSION: Our data suggest a role for miR-29b serum levels as a previously unrecognized biomarker for diagnosis of NET. +transcription factor target 32899767 hsa-mir-361 Intestinal Atresia We proved that miR5p is significantly upregulated during the atresia process and that it promotes GC apoptosis by directly targeting the VEGFA 3'UTR. +lncRNA target 32899503 hsa-mir-581 Colorectal Neoplasms In this study, we systematically analyzed the expression network of microRNAs (miRNAs) and genes in CRC metastasis using bioinformatics, and discovered that the miR-581/SMAD7 axis could be a potential factor that drives CRC metastasis. In conclusion, our findings elucidated that miR-581/SMAD7 could be essential for CRC metastasis, and may serve as a potential therapeutic target for CRC patients. +circulation_biomarker_diagnosis_ns 32899424 hsa-mir-21 Thyroid Cancer, Papillary We analyzed five miRNA molecules (miR-221; miR-222; miR-146b; miR-21; miR-181b) in the plasma of patients with papillary thyroid cancer (PTC), nodular goiter (NG) and healthy controls (HC) and evaluated their diagnostic value for differentiation of PTC from NG and HC. +circulation_biomarker_diagnosis_ns 32899424 hsa-mir-146b Thyroid Cancer, Papillary We analyzed five miRNA molecules (miR-221; miR-222; miR-146b; miR-21; miR-181b) in the plasma of patients with papillary thyroid cancer (PTC), nodular goiter (NG) and healthy controls (HC) and evaluated their diagnostic value for differentiation of PTC from NG and HC. +circulation_biomarker_diagnosis_ns 32899424 hsa-mir-181b Thyroid Cancer, Papillary We analyzed five miRNA molecules (miR-221; miR-222; miR-146b; miR-21; miR-181b) in the plasma of patients with papillary thyroid cancer (PTC), nodular goiter (NG) and healthy controls (HC) and evaluated their diagnostic value for differentiation of PTC from NG and HC. +circulation_biomarker_diagnosis_ns 32899424 hsa-mir-221 Thyroid Cancer, Papillary We analyzed five miRNA molecules (miR-221; miR-222; miR-146b; miR-21; miR-181b) in the plasma of patients with papillary thyroid cancer (PTC), nodular goiter (NG) and healthy controls (HC) and evaluated their diagnostic value for differentiation of PTC from NG and HC. +genetics_overexpression_promote 32899424 hsa-mir-222 Thyroid Cancer, Papillary It was demonstrated that miR-221; miR-222; miR-146b; miR-21 and miR-181b were overexpressed in preoperative PTC plasma samples compared to HC (p < 0.0001; p < 0.0001; p < 0.0001; p < 0.0001; p < 0.002; respectively). +circulation_biomarker_diagnosis_ns 32899377 hsa-mir-214 Telangiectasia, Hereditary Hemorrhagic Total RNA was purified from plasma, and three selected miRNAs (miRNA-10a, miRNA-214, and miRNA-370), related to the pathobiology of cardiovascular diseases and potentially targeting ENG or ALK1, were measured by quantitative polymerase chain reaction. +circulation_biomarker_diagnosis_up 32899377 hsa-mir-10a Telangiectasia, Hereditary Hemorrhagic Compared with controls, levels of miRNA-370, whose putative target is ENG, were significantly downregulated in HHT1, but not in HHT2, whereas the levels of miRNA-10a, whose putative target is ALK1, were significantly upregulated in HHT2, but not in HHT1. While further studies are warranted, these results suggest that dysregulated plasma levels of miRNA-370 or miRNA-10a could help to identify undiagnosed HHT1 or HHT2 patients, respectively. +circulation_biomarker_diagnosis_up 32899377 hsa-mir-370 Telangiectasia, Hereditary Hemorrhagic Compared with controls, levels of miRNA-370, whose putative target is ENG, were significantly downregulated in HHT1, but not in HHT2, whereas the levels of miRNA-10a, whose putative target is ALK1, were significantly upregulated in HHT2, but not in HHT1. While further studies are warranted, these results suggest that dysregulated plasma levels of miRNA-370 or miRNA-10a could help to identify undiagnosed HHT1 or HHT2 patients, respectively. +exosome 32899117 hsa-mir-614 Orofaciodigital Syndromes Among the exosomal miRNAs regulated differentially after 3 days of simulated NS versus DS, proof-of-concept validation of circadian misalignment signaling was demonstrated with hsa-mir5p. +exosome 32899117 hsa-mir-614 Netherton Syndrome Among the exosomal miRNAs regulated differentially after 3 days of simulated NS versus DS, proof-of-concept validation of circadian misalignment signaling was demonstrated with hsa-mir5p. +transcription factor target 32898999 hsa-mir-221 Osteonecrosis 5p may play important biological roles by repressing osteogenic target genes ALPL, PDGFA, and BMP2, and, therefore, contributing to progression of atrophic bone nonunion. +transcription factor target 32898999 hsa-mir-149 Osteonecrosis 5p may play important biological roles by repressing osteogenic target genes ALPL, PDGFA, and BMP2, and, therefore, contributing to progression of atrophic bone nonunion. +transcription factor target 32898999 hsa-mir-654 Osteonecrosis 5p may play important biological roles by repressing osteogenic target genes ALPL, PDGFA, and BMP2, and, therefore, contributing to progression of atrophic bone nonunion. +genetics_knock down_promote 32898639 hsa-mir-185 Osteosarcoma 3p overexpression inhibited osteosarcoma cell progression while lncRNA ROR elevation or miR +other 32898608 hsa-mir-34 Coronary Stenosis The monocyte PGE2 synthesis pathway is actively considered in the SNR and ISR patients and might be related to miR-34 and miR-520 functions. +other 32898608 hsa-mir-520 Coronary Disease The monocyte PGE2 synthesis pathway is actively considered in the SNR and ISR patients and might be related to miR-34 and miR-520 functions. +other 32898608 hsa-mir-520 Coronary Stenosis The monocyte PGE2 synthesis pathway is actively considered in the SNR and ISR patients and might be related to miR-34 and miR-520 functions. +other 32898608 hsa-mir-34 Coronary Disease The monocyte PGE2 synthesis pathway is actively considered in the SNR and ISR patients and might be related to miR-34 and miR-520 functions. +other 32898531 hsa-mir-2682 Urinary Bladder Neoplasms 5p feedback loop enhances cell growth, migration and invasion in BCa. +other 32898528 hsa-mir-24 Hypertrophy MiR-24 was found to directly bind to G6PD at the motif of CUGAGCC and regulated its expression, furtherly, influenced the G6PD-mediated mitochondrial dysfunction and oxidative stress of CH cells. SIGNIFICANCE: Generally, our study demonstrated that miR-24/G6PD regulates mitochondrial dysfunction and oxidative stress in CH cells, representing a new sight for CH therapy. +other 32898508 hsa-mir-132 Brain Ischemia Our findings show that DF3016A protects against the neuroinflammatory insult by activating brain-derived neurotrophic factor (BDNF) transcription pathway, which involves methyl CpG-binding protein 2 (MeCP2) and microRNA-132 (miR-132) regulatory factors, both required in nociceptive signaling and neuroinflammation. +circulation_biomarker_prognosis_up 32898433 hsa-mir-28 Stomach Neoplasms Conclusion: Our findings indicate that serum miR +exosome 32898324 hsa-mir-200c Colorectal Neoplasms We examined whether CSCs isolated from colorectal cancer (CRC) cells possess metastatic properties that can be transferred to non-CSCs via the delivery of miR-200c enclosed in extracellular vesicles (EVs). CSCs isolated from metastatic CRC cells exhibited higher levels of miR-200c than those in nonmetastatic CRC cells. +circRNA target 32897735 hsa-mir-379 Osteosarcoma Conclusion: Circ_SIPA1L1 promoted the progression of OS via miR +other 32897647 hsa-mir-141 Inflammation miR3p is proven to play a prominent role in various inflammation-related diseases. +transcription factor target 32897647 hsa-mir-141 Angelman Syndrome 3p is down-regulated during AS, and it can alleviate VSMCs' dysfunction by targeting the Keap1/Nrf2/HO-1 axis. +other 32897647 hsa-mir-141 Smooth Muscle Tumor Nonetheless, little is known concerning the function of miR3p in vascular smooth muscle cells (VSMCs) dysfunction and the underlying mechanism. +lncRNA target 32897512 hsa-mir-761 Glioma The present findings demonstrated that the interplay of KCNQ1OT1: miR-761: PIM1 regulated chemoresistance in gliomas and provided a promising therapeutic target for TMZ-resistant glioma patients. +other 32897245 hsa-mir-222 Ovarian Neoplasms HOXC10 promotes tumour metastasis by regulating the EMT-related gene Slug in ovarian cancer. HOXC10 is regulated by miR-222-3p. +lncRNA target 32897218 hsa-mir-485 Breast Neoplasms CONCLUSIONS MALAT1 can modulate paclitaxel resistance in breast cancer cells possibly by targeting miR +other 32897198 hsa-mir-144 Liver Neoplasms OBJECTIVE: To investigate the effects of over-expression of miR-144 on invasion of SMMC-7721 cells and Toll-like receptor (TLR)/myeloid differentiation factor 88 (MyD88) pathway in hepatocellular carcinoma cells. METHODS: The expressions of miR-144 was examined in normal human hepatocyte line HL-7702 and hepatocarcinoma cell line SMMC-7721 using realtime quantitative PCR (qRT-PCR). +other 32896817 hsa-mir-146a Dermatitis miR-146a is a negative regulator of inflammatory processes in both tissue-resident and specialized immune cells and may therefore have therapeutic effect in inflammatory skin diseases. +lncRNA target 32896760 hsa-mir-155 Glioblastoma This study opens new avenues for using IKK inhibitors and miRNA-155 replacement therapies for the treatment of AGTR1-positive malignancies. +target gene 32896720 hsa-mir-200 Head and Neck Neoplasms MiR-200 family inhibitors induced EMT and increased ferroptosis susceptibility. +genetics_knock down_suppress 32896523 hsa-mir-326 Glioma miR-326 was a target of circ0082374 and miR-326 knockdown attenuated the inhibitive role of circ0082374 silence in glioma progression. Collectively, silence of circ0082374 repressed the viability, migration, invasion and glycolysis in glioma cells by regulating miR-326 and SIRT1 in a ceRNA mechanism, providing a new mechanism for the pathogenesis of glioma. +transcription factor target 32896113 hsa-mir-589 Reperfusion Injury, Cerebral Ischemia MiRNA-589 is downregulated following cerebral IRI and alleviates inflammatory response through negatively regulating TRAF6. +exosome 32896063 hsa-mir-97 Colorectal Neoplasms In conclusion, our work reports a tumor-suppressing role for the circFNDC3B-miR5p-TIMP3 pathway and suggests that circFNDC3B-enriched exosomes can inhibit angiogenesis and CRC progression. +transcription factor target 32895884 hsa-mir-17 Myocardial Infarction, Acute 5p/Tsg101 regulatory axis in ER stress-induced myocardium injury and cardiomyocytes apoptosis, and presented a promising diagnostic biomarker and potential target for therapy of AMI. +genetics_overexpression_suppress 32895200 hsa-mir-204 Breast Neoplasms CONCLUSIONS: miR-204 expression is decreased in breast cancer tissues and cells, and its overexpression can inhibit the invasion and metastasis of breast cancer cells by targeted regulation of HNRNPA2B1. +other 32895132 hsa-mir-3133 Bloom Syndrome MiR-3133 was significantly downregulated in BLM group and upregulated in olmesartan group. +genetics_knock down_promote 32894569 hsa-mir-9 Pulmonary Fibrosis CONCLUSIONS Taken together, our findings showed that NEAT1 knockdown attenuated PF via the regulatory of miR +other 32894549 hsa-mir-890 Melanoma CONCLUSIONS: Our results demonstrated that LINC00662 facilitated the occurrence and development of melanoma by sponging miR-890 to upregulate ELK3. +lncRNA target 32894548 hsa-mir-106a Squamous Cell Carcinoma of Head and Neck Mechanistically, miR-106a-5p was a potential target of LINC00958, and its expression was negatively regulated by LINC00958 in HNSCC. CONCLUSIONS: Taken together, our results suggest that LINC00958 acts as an oncogenic role in HNSCC and activates AKT/mTOR signaling pathway by sponging miR-106a-5p. +other 32894547 hsa-mir-429 Nasopharyngeal Carcinoma CONCLUSIONS: Downregulation of miRNA-429 and upregulation of SOX2 are unfavorable to the prognosis of nasopharyngeal carcinoma. +genetics_knock down_promote 32894545 hsa-mir-1271 Carcinoma, Non-Small-Cell Lung Knockdown of CircRNA_103993 and high expression of miR-1271 significantly inhibited NSCLC cell proliferation and promoted apoptosis. +genetics_overexpression_promote 32894541 hsa-mir-34a Prostatic Neoplasms The beta-catenin level in the nucleus of PC3 cells was significantly reduced after overexpression of miRNA-34a. +lncRNA target 32894537 hsa-mir-1231 Ovarian Neoplasms Lower miR-1231 expression predicted a poor outcome in ovarian cancer patients and upregulation of miR-1231 expression inhibited cell growth. +lncRNA target 32894532 hsa-mir-145 Osteoarthritis CONCLUSIONS: MiR-145 can reduce OA-induced chondrocyte apoptosis through targeted inhibition on BNIP3 and regulation on Notch signaling pathway. +lncRNA target 32894531 hsa-mir-101 Neurodegenerative Diseases CONCLUSIONS: SNHG6 suppressed cell proliferation and induced apoptosis by increasing expression of Bax, caspase-3, p21 and decreasing Bcl-2 through targeting miR3p, which suggested that SNHG6 could be a potential target in the treatment of IDD. +circulation_biomarker_diagnosis_up 32894240 hsa-mir-223 Breast Neoplasms Excluding miR-20a-5p and miR3p, the 10 other miRNAs were all significantly upregulated in BC serum-derived exosomes. +circulation_biomarker_diagnosis_up 32894240 hsa-mir-20a Breast Neoplasms Excluding miR-20a-5p and miR3p, the 10 other miRNAs were all significantly upregulated in BC serum-derived exosomes. +other 32894165 hsa-mir-342 Glioma The U2AF2 /circRNA ARF1/miR3p/ISL2 feedback loop regulates angiogenesis in glioma stem cells. +other 32893980 hsa-mir-200b Lung Neoplasms What this study adds We demonstrated the potential of miR200b as a surrogate biomarker for PD-L1 expression in lung cancer patients. +circulation_biomarker_diagnosis_ns 32893872 hsa-mir-96 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 5p presented low expression levels by qPCR in peripheral blood of T-ALL patients compared to healthy volunteers. +other 32893562 hsa-mir-198 Pancreatitis In conclusion, curcumin has an ideal effect on acute pancreatitis, and its mechanism may be mediated by miRPI3 K-Akt axis. +transcription factor target 32893379 hsa-mir-211 Urinary Bladder Neoplasms 5p may play a role as a tumor suppressor and as a favourable prognostic marker in BCa. +other 32893175 hsa-mir-29b Liver Cirrhosis The effects of SNHG7 on the expression of miR-29b, DNMT3A and liver fibrosis related factors were detected in vitro or in vivo transfection experiments. +lncRNA target 32892696 hsa-mir-361 Retinoblastoma In conclusion, our data proved that hsa_circ_0000034 promoted the oncogenicity of retinoblastoma via regulation of miR +lncRNA target 32892554 hsa-mir-140 Esophageal Squamous Cell Carcinoma Targeting at miR +genetics_overexpression_promote 32892482 hsa-mir-10b Glioma Overexpression of TSLNC8 restrained glioma progression by suppressing miR-10b-5p. Our results indicate that the BACH2 and FUS/TSLNC8/miR-10b-5p/WWC3 axis is responsible for glioma development and could serve as a potential target for the development of new glioma therapies. +circulation_biomarker_diagnosis_ns 32892409 hsa-mir-98 Vascular Diseases Serum miR +genetics_GWAS 32892277 hsa-mir-518d Alzheimer Disease Four SNPs were associated with LOAD risk with a p value < 0.01 (rs74704964 in hsa-miR-518d, rs71363366 in hsa-miR2, rs11983381 in hsa-miR-4653, and rs10934682 in hsa-miR-544b). +genetics_GWAS 32892277 hsa-mir-4653 Alzheimer Disease Four SNPs were associated with LOAD risk with a p value < 0.01 (rs74704964 in hsa-miR-518d, rs71363366 in hsa-miR2, rs11983381 in hsa-miR-4653, and rs10934682 in hsa-miR-544b). +genetics_GWAS 32892277 hsa-mir-544b Alzheimer Disease Four SNPs were associated with LOAD risk with a p value < 0.01 (rs74704964 in hsa-miR-518d, rs71363366 in hsa-miR2, rs11983381 in hsa-miR-4653, and rs10934682 in hsa-miR-544b). +circRNA target 32891771 hsa-mir-148b Breast Neoplasms Overall, this study for the first time identified the tumor-suppressive role of circ_0000442 in breast cancer and found PTEN as a novel direct target of miR-148b-3p. +lncRNA target 32891166 hsa-mir-382 Pancreatic Carcinoma CONCLUSION: lncRNA PMSB8-AS1 promotes pancreatic cancer progression via STAT1 by sponging miR3p involving regulation PD-L1. +other 32891070 hsa-mir-181c Alzheimer Disease CONCLUSIONS: The findings of the present highlight the regulatory role of linc00507 in tau phosphorylation miR-181c-5p as ceRNA of MAPT/TTBK1 in vitro and in vivo, providing a basis for novel diagnostic and treatment strategies for AD. +other 32890792 hsa-mir-421 Reperfusion Injury, Cerebral Ischemia 3p is significantly decreased in cerebral I/R injury in vitro and in vivo. +genetics_overexpression_suppress 32890431 hsa-mir-145 Cardiomyopathies In the infarcted heart, the overexpression of miR-145 significantly ameliorated cardiac fibrosis and cardiac function, and there was a negative correlation between miR-145 and SOX9 expressions in hypoxic CFs in vitro. +lncRNA target 32890417 hsa-mir-217 Thyroid Neoplasms Circ_0000144 serves as a novel oncogenic circRNA, and miR-217 is reported to inhibit the malignant phenotypes of cancer cells by targeting AKT3 in TC. +transcription factor target 32889908 hsa-mir-155 Influenza, Human In this study, we explored the role as well as the underlying mechanism of miR-155 in the cytokine production in influenza A-infected endothelial cells. CONCLUSION: MiR-155 maybe modulate influenza A-induced inflammatory response by targeting S1PR1. +lncRNA target 32889897 hsa-mir-338 Hypopharyngeal Neoplasms 3p targets ADAM17 and blocks the development of hypopharyngeal carcinoma involving the wnt/beta-catenin signaling pathway, which may be a new target for clinical intervention in human cancer. +lncRNA target 32889894 hsa-mir-455 Colorectal Neoplasms 5p inhibitor in CRC cells. +lncRNA target 32889799 hsa-mir-34a Nasopharyngeal Neoplasms All these results suggested that the lncRNA FAM133B-2 might function as a competitive endogenous RNA (ceRNA) for miR-34a-5p in nasopharyngeal carcinoma radio-resistance, thus it may be regarded as a novel prognostic biomarker and therapeutic target in nasopharyngeal carcinoma diagnosis and treatment. +other 32889692 hsa-mir-671 Cerebellar Diseases The purpose of this paper is to study the effect of circRNA cerebellar degeneration-related protein 1 antisense RNA(CDR1as)/miR-671/GSK3beta signaling pathway on PC12 cell injury and the mechanism of Exendin-4 (Ex-4) in PC12 cell injury protection. +genetics_overexpression_promote 32889668 hsa-mir-29a Cerebral Hemorrhage Further study documented that lentivirus-mediated miR-29a overexpression could remarkably attenuate hemorrhagic brain injury, promoted regenerative outgrowth of injured axons and improved neurobehavioral and cognitive impairments after ICH in rats. +exosome 32889404 hsa-mir-23a Oculodentodigital Dysplasia Therefore, our findings suggest that by transferring miR-23a, exosome secreted by human gingival fibroblasts in radiation therapy serves a vital role in osteogenic differentiation of hBMSCs, which may provide novel clinical treatments for ORNJ. +genetics_knock down_promote 32889066 hsa-mir-216a Neuralgia Our results showed that the expression of miR-216a-5p was downregulated in CCI rats, and mechanical allodynia and thermal hyperalgesia in CCI rats were improved by miR-216a-5p overexpression, suggesting that miR-216a-5p overexpression alleviated neuropathic pain. +lncRNA target 32889056 hsa-mir-185 Diabetic Nephropathies CONCLUSION: Overall, circHIPK3 exhibits a promotive function in DN by sponging miR-185 and this evidence suggests that circHIPK3 might be a biomarker or therapeutic target for DN. +circulation_biomarker_diagnosis_up 32889008 hsa-mir-9 Diabetes Mellitus, Type 2 MiR9+/+-T2DM-MSC-Exo treatment significantly increases serum miR-9 expression compared to PBS treated and T2DM-MSC-Exo treated T2DM stroke rats. +lncRNA target 32888967 hsa-mir-21 Ophthalmoplegia, Chronic Progressive External Collectively, our findings demonstrated that miR5p was involved in regulating the immune response triggered by CPB2 toxin and contributed to protective effects in CPB2-induced CPED cell model by targeting PDCD4. +transcription factor target 32888955 hsa-mir-211 Melanoma Consistent with this model, miR-211 expression increased melanoma cell resistance to both the inhibitors, and this resistance was associated with an increased ERK5 phosphorylation. +genetics_overexpression_promote 32888745 hsa-mir-187 Cicatrix, Hypertrophic 3p overexpression-induced effects on cell proliferation, apoptosis, migration, and invasion of HS fibroblasts. +other 32888289 hsa-mir-548am Hypertension We also discovered 4 miRNAs (hsa-miR-548am-3p, hsa-miR-513c-3p, hsa-miR5p, and hsa-miR-548d-5p) and 6 genes (IGF1R, GSK3B, FOXO1, PRKAR2B, HIF1A, and PIK3R1) were the core nodes in the hypertension-related miRNA-gene network, and hsa-miR-548am-3p was at the center of the network. +other 32888289 hsa-mir-182 Hypertension We also discovered 4 miRNAs (hsa-miR-548am-3p, hsa-miR-513c-3p, hsa-miR5p, and hsa-miR-548d-5p) and 6 genes (IGF1R, GSK3B, FOXO1, PRKAR2B, HIF1A, and PIK3R1) were the core nodes in the hypertension-related miRNA-gene network, and hsa-miR-548am-3p was at the center of the network. +lncRNA target 32888161 hsa-mir-98 Cardiomyopathies 5p/CRP axis, suggesting that TTTY15 might be a potential target for alleviating AMI-caused myocardial cell injury. +lncRNA target 32888161 hsa-mir-98 Myocardial Infarction 5p/CRP axis, suggesting that TTTY15 might be a potential target for alleviating AMI-caused myocardial cell injury. +genetics_overexpression_promote 32888158 hsa-mir-204 Obesity Overexpression of TUG1 could suppress the inflammation in adipocytes via downregulating miR-204 and promote GLUT4/PPARgamma/AKT pathway high-glucose-induced inflammation in 3T3-L1 cells. +genetics_GWAS 32888124 hsa-mir-630 Glioblastoma The overexpression of miR-630 was associated with reduced cell proliferation and invasion in the U87 GBM cell line, whereas the inhibition of miR-10b-5p reduced cell proliferation and colony formation in the U251 GBM cell line, suggesting that these miRNAs may act as tumor-suppressive and oncogenic miRNAs, respectively. +genetics_GWAS 32888124 hsa-mir-10b Glioblastoma The overexpression of miR-630 was associated with reduced cell proliferation and invasion in the U87 GBM cell line, whereas the inhibition of miR-10b-5p reduced cell proliferation and colony formation in the U251 GBM cell line, suggesting that these miRNAs may act as tumor-suppressive and oncogenic miRNAs, respectively. +lncRNA target 32888019 hsa-mir-103 Sciatic Neuropathy In conclusion, LncRNA BC083743 promotes SC proliferation and the axon regeneration through miR +transcription factor target 32887903 hsa-mir-4282 Mouth Neoplasms The MiRNA target prediction showed functional molecular annotation including specific miRNA-targets hsa-miR-4282, hsa-miR-2052, hsa-miR-216a-3p, for CYP1B1, C7, and ADCY2 respectively associated with oral cancer. +transcription factor target 32887903 hsa-mir-2052 Mouth Neoplasms The MiRNA target prediction showed functional molecular annotation including specific miRNA-targets hsa-miR-4282, hsa-miR-2052, hsa-miR-216a-3p, for CYP1B1, C7, and ADCY2 respectively associated with oral cancer. +transcription factor target 32887903 hsa-mir-216a Mouth Neoplasms The MiRNA target prediction showed functional molecular annotation including specific miRNA-targets hsa-miR-4282, hsa-miR-2052, hsa-miR-216a-3p, for CYP1B1, C7, and ADCY2 respectively associated with oral cancer. +circulation_biomarker_diagnosis_ns 32887156 hsa-mir-122 Liver Injury In this study, dynamic chemical labelling was combined with the Luminex MAGPIX system to profile levels of microRNA-122 biomarker in serum from patients with Drug-Induced Liver Injury. +lncRNA target 32887025 hsa-mir-22 Glioma Taken together, NCK1-AS1 contributes to glioma cell proliferation, radioresistance and chemoresistance via miR +genetics_knock down_suppress 32886453 hsa-mir-506 Neuroblastoma CONCLUSIONS: Knockdown of LINC01410 inhibited the development of NBL by miR +genetics_overexpression_promote 32886291 hsa-mir-183 Esophageal Squamous Cell Carcinoma MiR-183 is a tumor onco-miR and has been shown by our previous studies to be overexpressed in esophageal squamous cell carcinomas (ESCCs). +exosome 32885987 hsa-mir-376a Pulmonary Arterial Hypertension Expression of extracellular vesicle miRNAs-21, -29c, and -376a was higher in PAH, moderated by E2 and DHEA-S levels, and tracked with hormone-associated changes in clinical measures.Conclusions: Women with PAH have fluctuations in cardiopulmonary function during menstruation driven by E2 and DHEA-S. +exosome 32885987 hsa-mir-21 Pulmonary Arterial Hypertension Expression of extracellular vesicle miRNAs-21, -29c, and -376a was higher in PAH, moderated by E2 and DHEA-S levels, and tracked with hormone-associated changes in clinical measures.Conclusions: Women with PAH have fluctuations in cardiopulmonary function during menstruation driven by E2 and DHEA-S. +exosome 32885987 hsa-mir-29c Pulmonary Arterial Hypertension Expression of extracellular vesicle miRNAs-21, -29c, and -376a was higher in PAH, moderated by E2 and DHEA-S levels, and tracked with hormone-associated changes in clinical measures.Conclusions: Women with PAH have fluctuations in cardiopulmonary function during menstruation driven by E2 and DHEA-S. +transcription factor target 32885857 hsa-mir-193b Melanoma Furthermore, the data may suggest to consider the use of the tumor suppressor miR-193b as a strategy for countering TRAIL resistance in melanoma. +transcription factor target 32885809 hsa-mir-132 Cardiomyopathies These results indicated that the up-regulation of miR-132 improved the cardiac dysfunction, attenuated cardiac fibrosis in heart failure via inhibiting PTEN expression, and attenuating PI3K/Akt signal pathway. Up-regulation of miR-132 may be a strategy for the treatment of heart failure and cardiac fibrosis. +transcription factor target 32885809 hsa-mir-132 Heart Failure These results indicated that the up-regulation of miR-132 improved the cardiac dysfunction, attenuated cardiac fibrosis in heart failure via inhibiting PTEN expression, and attenuating PI3K/Akt signal pathway. Up-regulation of miR-132 may be a strategy for the treatment of heart failure and cardiac fibrosis. +genetics_knock down_promote 32885717 hsa-mir-499a Carcinoma, Non-Small-Cell Lung Finally, rescue experiments confirmed that silencing of fibroblast growth factor 9 partially reversed the phenotypes of miR-499a-5p knockdown on non-small cell lung cancer cell proliferation. +other 32884997 hsa-mir-199a Glioblastoma One of them, hsa-miR-199a-3p, was significantly correlated with the survival of GBM patients, and differentially expressed in U87S cells. +genetics_knock down_promote 32884956 hsa-mir-138 Carcinoma, Renal Cell 5p overexpression or TMEM40 knockdown significantly suppressed ccRCC cell proliferation, migration and invasion in vitro. +lncRNA target 32884953 hsa-mir-103a Inflammation CONCLUSIONS: Taken together, our study suggests that miR-103a-3p inhibits chondrocyte apoptosis and inflammation in OA, which appears to be an attractive approach to OA treatment. +lncRNA target 32884953 hsa-mir-103a Osteoarthritis CONCLUSIONS: Taken together, our study suggests that miR-103a-3p inhibits chondrocyte apoptosis and inflammation in OA, which appears to be an attractive approach to OA treatment. +other 32884568 hsa-mir-30 Diabetes Mellitus, Type 2 Increased expression of microRNA-330 was observed in hypertensive cases (9.61-fold, p < 0.0001), obese cases (9.33-fold, p=0.0008, alcoholic cases (9.07-fold, p < 0.0001), and smoking cases (8.41-fold, p=0.01) as compared to nonhypertensive, nonobese nonalcoholic, and nonsmoking cases, and differences among them were found to be significant. +other 32884447 hsa-mir-485 Uterine Cervical Neoplasms LncRNA SNHG6 enhances the radioresistance and promotes the growth of cervical cancer cells by sponging miR-485-3p. +genetics_overexpression_promote 32884351 hsa-mir-610 Carcinoma, Hepatocellular Further, FGFR1 was targeted by miR-610, and FGFR1 overexpression overturned the effects of miR-610 restoration in HCC cells. CONCLUSION: Circ_0015756 played its tumorigenic properties in HCC by activating FGFR1 via sponging miR-610, and circ_0015756 was expected to be a vital indicator in HCC diagnosis and treatment. +other 32884349 hsa-mir-382 Carcinoma, Renal Cell Mechanistically, circ-SAR1A upregulated YBX1 expression by sponging miR-382, resulting in promoting the growth and invasion in RCC cells. CONCLUSION: Our data indicate that the circ-SAR1A/miR-382/YBX1 axis plays a critical role in RCC progression, which serve as a potential novel treatment strategy of RCC. +genetics_knock down_promote 32884344 hsa-mir-7 Carcinoma, Pancreatic Ductal CONCLUSION: Circ_0013912 knockdown could suppress cell growth and metastasis of PDAC cells via sponging miR +genetics_knock down_promote 32884343 hsa-mir-770 Ovarian Neoplasms NEAT1 Knockdown Suppresses the Cisplatin Resistance in Ovarian Cancer by Regulating miR-770-5p/PARP1 Axis. +circRNA target 32884340 hsa-mir-22 Squamous Cell Carcinoma of Head and Neck ENO1 may play a role as a tumor-promoting gene in OSCC through the circ-AMOTL1/miR +circRNA target 32884340 hsa-mir-1294 Squamous Cell Carcinoma of Head and Neck ENO1 may play a role as a tumor-promoting gene in OSCC through the circ-AMOTL1/miR +target gene 32884303 hsa-mir-27b Colorectal Neoplasms LINC01089 Blocks the Proliferation and Metastasis of Colorectal Cancer Cells via Regulating miR-27b-3p/HOXA10 Axis. +lncRNA target 32884301 hsa-mir-421 Ovarian Neoplasms MATERIALS AND METHODS: The dual-luciferase reporter system assay was used to determine the interaction between circEXOC6B, miR-421 and RUS1 in ovarian cancer, respectively. CONCLUSION: In this study, we found that circEXOC6B suppressed the growth of ovarian cancer cells through upregulating RSU1 partially via sponging miR-421. +transcription factor target 32884297 hsa-mir-140 Carcinoma, Non-Small-Cell Lung QRT-PCR analysis was performed to compare the expression of miR-140 between routine NSCLC cells and cisplatin-resistant NSCLC cells. CONCLUSION: MiR-140 resensitizes cisplatin-resistant NSCLC cells to cisplatin treatment through the SIRT1/ROS/JNK pathway. +genetics_overexpression_promote 32884289 hsa-mir-654 Carcinoma, Non-Small-Cell Lung 3p overexpression on NSCLC cell proliferation. +target gene 32884288 hsa-mir-133b Stomach Neoplasms miR-133b Suppresses Invasion and Migration of Gastric Cancer Cells via the COL1A1/TGF-β Axis. +other 32884286 hsa-mir-137 Prostatic Neoplasms miR-137-3p Modulates the Progression of Prostate Cancer by Regulating the JNK3/EZH2 Axis. +other 32883962 hsa-mir-107 Prostatic Neoplasms mediated GRN regulation in response to ionizing radiation and may advance therapeutic strategies for the treatment of prostate cancer. +other 32883688 hsa-mir-6751 Diabetes Mellitus Additionally, moving stepwise from HV to patients with obesity without DM to patients with obesity with DM, there was a consistent increase in expression levels of miR-23a-5p and miR-6087 and a consistent decrease in expressions levels of miR3p. +other 32883688 hsa-mir-6751 Obesity Additionally, moving stepwise from HV to patients with obesity without DM to patients with obesity with DM, there was a consistent increase in expression levels of miR-23a-5p and miR-6087 and a consistent decrease in expressions levels of miR3p. +other 32883688 hsa-mir-6087 Obesity Additionally, moving stepwise from HV to patients with obesity without DM to patients with obesity with DM, there was a consistent increase in expression levels of miR-23a-5p and miR-6087 and a consistent decrease in expressions levels of miR3p. +other 32883688 hsa-mir-6087 Diabetes Mellitus Additionally, moving stepwise from HV to patients with obesity without DM to patients with obesity with DM, there was a consistent increase in expression levels of miR-23a-5p and miR-6087 and a consistent decrease in expressions levels of miR3p. +genetics_knock down_promote 32883551 hsa-mir-150 Carcinoma, Hepatocellular CONCLUSIONS: Overall, our findings suggest that the loss of antitumoral miR +genetics_knock down_promote 32883538 hsa-mir-203 Keloid LINC01116 knockdown suppressed the proliferation, migration, invasion, and ECM production but induced apoptosis in keloid fibroblasts through enhancing miR-203 and inhibiting SMAD5. +genetics_overexpression_promote 32883329 hsa-mir-212 Osteosarcoma Also, lupeol administration exerts its anti-tumor effect by overexpression of miR +other 32883233 hsa-mir-154 Breast Neoplasms SNHG3 could act as a competing endogenous RNA of miR3p and upregulate the Notch signaling pathway to promote BC cell development. +genetics_knock down_suppress 32883232 hsa-mir-876 Astrocytoma More importantly, the impacts of SNHG17 down-regulation on the malignant behaviors of astrocytoma cells were counteracted by overexpressed ERLIN2 or inhibited miR +lncRNA target 32882762 hsa-mir-542 Hyperlipidemias 5p inhibits hyperglycemia and hyperlipoidemia by targeting FOXO1. +lncRNA target 32882762 hsa-mir-542 Retinitis 5p inhibits hyperglycemia and hyperlipoidemia by targeting FOXO1. +circulation_biomarker_diagnosis_ns 32882180 hsa-mir-142 Myocarditis Collectively, our results indicate a newly endogenous mechanism whereby circulating exosomes regulate CD4(+) T cell immunometabolic dysfunction and EAM pathogenesis via cargo miR-142. +lncRNA target 32882142 hsa-mir-202 Endometrial Neoplasms 3p inhibitor neutralized NEAT1 silencing mediated suppression on EC cell progression. +transcription factor target 32882141 hsa-mir-107 Acute Aortic Dissection 5p inhibited the progression of acute AD through targeted ITM2C. +other 32881717 hsa-mir-421 Thyroid Cancer, Papillary Moreover, the upregulation of miR-421 enhances the proliferation, migration, and invasion of PTC cells. +other 32881662 hsa-mir-29c Osteoarthritis hsa-miR-29a-3p, hsa-miR-29b-3p, and hsa-miR-29c-3p were predicted to be important miRNAs for OA, while hsa_circ_0025119, hsa_circ_0025113, hsa_circ_0009897, and hsa_circ_0002447 were predicted to be the most important circRNAs. +other 32881662 hsa-mir-29b Osteoarthritis hsa-miR-29a-3p, hsa-miR-29b-3p, and hsa-miR-29c-3p were predicted to be important miRNAs for OA, while hsa_circ_0025119, hsa_circ_0025113, hsa_circ_0009897, and hsa_circ_0002447 were predicted to be the most important circRNAs. +other 32881598 hsa-mir-21 Uterine Cervical Neoplasms Therefore, LOXL1-AS1 may promote CSCC cell invasion and migration by sponging miR-21 to upregulate RHOB. +transcription factor target 32881411 hsa-mir-642a Acute Lung Injury Thus, miR-642a-5p and eEF2 may serve as potential targets for acute lung injury/acute respiratory distress syndrome diagnosis or treatment. +transcription factor target 32881411 hsa-mir-642a Respiratory Distress Syndrome The miRNA miR-642a-5p has previously been reported to be up-regulated in patients with acute respiratory distress syndrome; thus, here, we examined whether this miRNA is involved in the effects of LPS on PMVECs. Thus, miR-642a-5p and eEF2 may serve as potential targets for acute lung injury/acute respiratory distress syndrome diagnosis or treatment. +transcription factor target 32881411 hsa-mir-642a Lung Injury Thus, miR-642a-5p and eEF2 may serve as potential targets for acute lung injury/acute respiratory distress syndrome diagnosis or treatment. +transcription factor target 32881411 hsa-mir-642a Attention Deficit Disorder with Hyperactivity We report that miR-642a-5p levels are significantly up-regulated in LPS-stimulated PMVECs, and miR-642a-5p contributes to LPS-induced hyperpermeability and apoptosis of PMVECs. miR-642a-5p promoted LPS-induced hyperpermeability and apoptosis by targeting eEF2. +genetics_overexpression_promote 32881354 hsa-mir-23a Diabetes Mellitus, Type 2 miR-23a-3p overexpression alleviated liver and kidney damage in type 2 diabetes mellitus rats, and reduced NLRP3-induced pyroptosis. +lncRNA target 32881231 hsa-mir-944 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: In short, lncRNA JPX contributes to OSCC cell proliferation, migration, and invasion via miR-944/CDH2 axis, which offers a new direction for potential targeted treatment of OSCC. +target gene 32881074 hsa-mir-215 Psoriasis MicroRNA-215-5p inhibits the proliferation of keratinocytes and alleviates psoriasis-like inflammation by negatively regulating DYRK1A and its downstream signalling pathways. +genetics_GWAS 32880825 hsa-mir-143 Breast Neoplasms 3p RALGAPA2 axis in breast cancer, whereby the latter can be altered by the clinically functional SNP rs3827693. +other 32880813 hsa-mir-449a Pituitary Neoplasms Our study highlighted the essential oncogenic properties of the SNHG7/miR-449a axis in pituitary adenoma. +other 32880505 hsa-mir-205 Cardiomyopathies This study was aimed to investigate the role of microRNA-205 (miR-205) on PM(2.5)-induced myocardial inflammation and cardiac dysfunction. +lncRNA target 32880393 hsa-mir-197 Osteoarthritis Taken together, our study demonstrated that miR-197 promotes chondrocyte proliferation, increases migration, and inhibits inflammation in the pathogenesis of OA by targeting EIF4G2, indicating the potential therapeutic targets of the miR-197/EIF4G2 axis for OA treatment. +other 32880387 hsa-mir-142 Myocardial Infarction In our study, we generated a new differentially expressed miRNA (DEmiRNA)-differentially expressed gene (DEG) cross-talk network of MI composed of three miRNA (miR-489, miR-375, and miR3p) nodes and 163 mRNA nodes. +other 32880387 hsa-mir-489 Cardiomyopathies In vitro experiments demonstrated that miR-489 expression was increased in H2O2-treated H9c2 cardiomyocytes in vitro, mimicking myocardial injury. +other 32880387 hsa-mir-489 Myocardial Infarction In our study, we generated a new differentially expressed miRNA (DEmiRNA)-differentially expressed gene (DEG) cross-talk network of MI composed of three miRNA (miR-489, miR-375, and miR3p) nodes and 163 mRNA nodes. +other 32879620 hsa-mir-10a Metabolic Diseases Therefore, miRNA-10a-5p may have preventative properties in subjects with metabolic disorders. +other 32879620 hsa-mir-10a Obesity However, the effects of miRNA-10a on obesity and glucose intolerance, as well as on the diurnal pattern of expression of circadian clock genes, remain unknown. +lncRNA target 32879620 hsa-mir-10a Glucose Intolerance However, the effects of miRNA-10a on obesity and glucose intolerance, as well as on the diurnal pattern of expression of circadian clock genes, remain unknown. In conclusion, we suggest that miRNA-10a-5p may improve HFD-induced glucose intolerance and insulin resistance through the modulation of the diurnal rhythm of Lachnospiraceae and its metabolite butyrate. +other 32879391 hsa-let-7i Carcinoma, Hepatocellular Correlation analysis of the miRNA signature and its co-expressed miRNAs revealed that hsa-let-7i and its 13 co-expressed miRNAs are significantly involved in the hepatitis B pathway. +lncRNA target 32879299 hsa-mir-143 Squamous Cell Carcinoma of Head and Neck 3p/MAGEA9 axis, thus providing new therapeutic targets for treatment of OSCC. +circulation_biomarker_diagnosis_up 32879124 hsa-mir-455 Mucocutaneous Lymph Node Syndrome 5p in both of acute and recovery KD children's plasma is remarkably lower than that in the normal control, and miR +other 32878636 hsa-mir-155 Encephalomyelitis, Acute Disseminated Administering anti-miR-155 during infection could provide a novel avenue for reducing post-infectious neuroinflammation. +genetics_knock down_promote 32878470 hsa-mir-223 Pancreatic Carcinoma mediated SLC4A4 inhibition.NEW & NOTEWORTHY Human circular (hsa_circ)RNA_001587 and solute carrier family 4 member 4 (SLC4A4) are poorly expressed but microRNA (miR)R-223 is overexpressed in pancreatic cancer (PC) cells. +circulation_biomarker_diagnosis_up 32878466 hsa-mir-375 Pancreatitis, Chronic During islet infusion, serum cytokine (IL-6, IL-8, and MCP-1) levels and plasma hsa-miR-375 levels were lower in the CAA group than in the NAA group, but not significantly. +transcription factor target 32878300 hsa-mir-1 Pre-Eclampsia 3p may serve as reliable diagnostic or prognostic tools for PE, thereby providing evidence that these miRNAs are promising mechanism-based targets for designing therapeutic and preventive strategies for the clinical management of PE. +transcription factor target 32878300 hsa-mir-1290 Pre-Eclampsia 3p may serve as reliable diagnostic or prognostic tools for PE, thereby providing evidence that these miRNAs are promising mechanism-based targets for designing therapeutic and preventive strategies for the clinical management of PE. +transcription factor target 32878300 hsa-mir-214 Pre-Eclampsia 3p may serve as reliable diagnostic or prognostic tools for PE, thereby providing evidence that these miRNAs are promising mechanism-based targets for designing therapeutic and preventive strategies for the clinical management of PE. +transcription factor target 32878300 hsa-mir-155 Pre-Eclampsia 3p may serve as reliable diagnostic or prognostic tools for PE, thereby providing evidence that these miRNAs are promising mechanism-based targets for designing therapeutic and preventive strategies for the clinical management of PE. +circulation_biomarker_diagnosis_ns 32877980 hsa-mir-214 Fractures, Bone OBJECTIVE: To investigate the expression of micro ribonucleic acid (miR)-214 in the bone tissue and blood of patients with fragility fracture. RESULTS: The expression of miR-214 in the bone tissue and blood of patients with fragility fracture significantly declined. +transcription factor target 32877893 hsa-mir-210 Hemangioma CONCLUSION: Silencing miR-210 in HUVEC-derived EVs could suppress Hem by targeting HOXA9. +genetics_knock down_promote 32877662 hsa-mir-4425 Ovarian Neoplasms Here we report that miR-4425 is upregulated in ovarian cancer tissues relative to normal ovarian tissues, and transfection of miR-4425 inhibitor impairs the proliferation, migration and invasion of SKOV3 and 3AO ovarian cancer cells. +circRNA target 32877369 hsa-mir-147a Carcinoma, Ovarian Epithelial CONCLUSIONS: Our results revealed that circ_0072995 promoted EOC progression through the circ_0072995/miR-147a/CDK6 axis and may represent a strategy for treatment of EOC afflicted patients. +genetics_GWAS 32877242 hsa-mir-143 Diabetes Mellitus, Type 2 Assessment of epigenetic mechanisms through microRNAs (miRs) by a real-time PCR-based microarray in islets revealed elevation in miRs that regulate insulin secretion (miRs 342, 143), insulin resistance (miR143), and obesity (miR219). +genetics_GWAS 32877242 hsa-mir-143 Insulin Resistance Assessment of epigenetic mechanisms through microRNAs (miRs) by a real-time PCR-based microarray in islets revealed elevation in miRs that regulate insulin secretion (miRs 342, 143), insulin resistance (miR143), and obesity (miR219). +genetics_GWAS 32877242 hsa-mir-219 Insulin Resistance Assessment of epigenetic mechanisms through microRNAs (miRs) by a real-time PCR-based microarray in islets revealed elevation in miRs that regulate insulin secretion (miRs 342, 143), insulin resistance (miR143), and obesity (miR219). +genetics_GWAS 32877242 hsa-mir-219 Diabetes Mellitus, Type 2 Assessment of epigenetic mechanisms through microRNAs (miRs) by a real-time PCR-based microarray in islets revealed elevation in miRs that regulate insulin secretion (miRs 342, 143), insulin resistance (miR143), and obesity (miR219). +exosome 32876927 hsa-mir-152 Thyroid Neoplasms miR-152 ferried by BM-MSCs-derived exosomes repressed THCA cell invasion and migration, and pcDNA-DPP4 weakened the repression effect. +transcription factor target 32876895 hsa-mir-532 Inflammation Overall, we suggest that miR3p attenuates the pro-inflammatory nature of macrophages by targeting ASK1/p38 MAPK signaling pathway and can be used as a molecular intervention for treating inflammatory diseases. +other 32876691 hsa-let-7g Uveitis Furthermore, we identified miR3p, miR-4323, and let-7g-3p as the best predictor miRNAs for BD, sarcoidosis, and VKH, respectively. +other 32876691 hsa-mir-4708 Uveitis Furthermore, we identified miR3p, miR-4323, and let-7g-3p as the best predictor miRNAs for BD, sarcoidosis, and VKH, respectively. +other 32876691 hsa-mir-4323 Uveitis Furthermore, we identified miR3p, miR-4323, and let-7g-3p as the best predictor miRNAs for BD, sarcoidosis, and VKH, respectively. +other 32876518 hsa-mir-18b Nonsyndromic sensorineural hearing loss CONCLUSIONS AND SIGNIFICANCE: Using methods combining the evaluation of miR-183, miR-210, miR-18b, and miR-23a cut-off values identified in ISSNHL patients and healthy controls during receiver operating characteristic curve analysis, sensitivity and specificity of 80.95% (17/21) and 87.50% (21/24) were obtained, respectively. +other 32876518 hsa-mir-210 Nonsyndromic sensorineural hearing loss CONCLUSIONS AND SIGNIFICANCE: Using methods combining the evaluation of miR-183, miR-210, miR-18b, and miR-23a cut-off values identified in ISSNHL patients and healthy controls during receiver operating characteristic curve analysis, sensitivity and specificity of 80.95% (17/21) and 87.50% (21/24) were obtained, respectively. +other 32876518 hsa-mir-23a Nonsyndromic sensorineural hearing loss CONCLUSIONS AND SIGNIFICANCE: Using methods combining the evaluation of miR-183, miR-210, miR-18b, and miR-23a cut-off values identified in ISSNHL patients and healthy controls during receiver operating characteristic curve analysis, sensitivity and specificity of 80.95% (17/21) and 87.50% (21/24) were obtained, respectively. +other 32876518 hsa-mir-183 Nonsyndromic sensorineural hearing loss CONCLUSIONS AND SIGNIFICANCE: Using methods combining the evaluation of miR-183, miR-210, miR-18b, and miR-23a cut-off values identified in ISSNHL patients and healthy controls during receiver operating characteristic curve analysis, sensitivity and specificity of 80.95% (17/21) and 87.50% (21/24) were obtained, respectively. +lncRNA target 32876500 hsa-mir-24 Glioma These results suggested that miR-24 was elevated in glioma, and miR-24 could promote glioma progression by facilitating cell proliferation and inducing cell apoptosis through CDX1/PI3K/Akt signaling pathway, indicating a novel pathway underlying progression in glioma cells and providing a potential target for glioma treatment. +other 32876337 hsa-mir-147a Periodontitis 5p were significantly up-regulated in LAP compared to HC. +other 32876337 hsa-mir-9 Periodontitis 5p were significantly up-regulated in LAP compared to HC. +other 32876337 hsa-mir-155 Periodontitis 5p were significantly up-regulated in LAP compared to HC. +other 32876337 hsa-mir-182 Periodontitis 5p were significantly up-regulated in LAP compared to HC. +exosome 32876110 hsa-mir-21 Lupus Erythematosus, Systemic CONCLUSIONS These findings suggested that exosomal miR-21 and miR-155 expression levels may serve as potential biomarkers for the diagnosis of SLE and LN. +exosome 32876110 hsa-mir-155 Lupus Erythematosus, Systemic CONCLUSIONS These findings suggested that exosomal miR-21 and miR-155 expression levels may serve as potential biomarkers for the diagnosis of SLE and LN. +transcription factor target 32876075 hsa-mir-22 Venous Thrombosis 3p was upregulated in EPCs derived from deep VT (DVT) individuals and suppression of miR +circulation_biomarker_diagnosis_ns 32875710 hsa-mir-221 Prostatic Neoplasms More importantly, hsa-miR3p, 146a-5p, and 27a-3p were increased in bloodstream of PCa patients compared to healthy donors. +other 32875345 hsa-mir-134 Ovarian Neoplasms 5p to elevate RAD18 expression, resulting in aggravated development of ovarian cancer. +genetics_overexpression_promote 32874130 hsa-mir-145 Stomach Neoplasms Overexpression of miR +lncRNA target 32874129 hsa-mir-99a Stomach Neoplasms CONCLUSIONS: Our findings suggested that MIR99AHG contributes to malignant phenotypes of GC and may become a promising therapeutic target. +circulation_biomarker_prognosis_ns 32873879 hsa-mir-221 Heart Failure Furthermore, serum miR +genetics_overexpression_suppress 32873299 hsa-mir-124 Adenocarcinoma of Lung CONCLUSIONS: Our results suggest that miR-124 overexpression can negatively regulate AKT2 and thus inhibit the progression of LUAD. +transcription factor target 32872332 hsa-mir-185 Respiratory Distress Syndrome THC caused the downregulation of miR-185, which correlated with an increase in the pro-apoptotic gene targets. +other 32872191 hsa-mir-339 Subaneurysmal Aortic Dilation MiR3p, alone or in combination with other miRs, could be used for SAD screening in high cardiovascular risk patients, helping to the early diagnosis of asymptomatic AAA. +transcription factor target 32872046 hsa-mir-181a Femur Head Necrosis Among DE miRNAs, MiR-181a-5p and miR5p may contribute to the development femoral head osteonecrosis after femur neck fracture via ubiquitin proteasome system. +lncRNA target 32872046 hsa-mir-140 Femur Head Necrosis 5p may contribute to the development femoral head osteonecrosis after femur neck fracture via ubiquitin proteasome system. +other 32871993 hsa-mir-21 Lung Neoplasms CONCLUSION: The study will provide updated evidence to evaluate whether the expression of miRNA-21 is in association with poor prognosis in patients with lung cancer. +other 32871962 hsa-mir-21 Pancreatic Carcinoma CONCLUSION: Our findings will show the effect of high expression of miRNA-21 on the prognosis of patients with pancreatic cancer. +other 32871952 hsa-mir-363 Thyroid Cancer, Papillary Two DEMs, miRNA-146b-3p (HR: 1.327, 95% CI = 1.135-1.551, P = .000) and miRNA3p (HR: 0.714, 95% CI = 0.528-0.966, P = .029), were significantly associated with CLNM. +other 32871952 hsa-mir-146b Thyroid Cancer, Papillary Two DEMs, miRNA-146b-3p (HR: 1.327, 95% CI = 1.135-1.551, P = .000) and miRNA3p (HR: 0.714, 95% CI = 0.528-0.966, P = .029), were significantly associated with CLNM. +genetics_overexpression_promote 32871922 hsa-mir-9 Osteosarcoma Based on TCGA data, osteosarcoma patients with overexpression of miR +other 32871756 hsa-mir-99b Pre-Eclampsia RESULTS: miR-23b-5p and miR-99b-5p were down-regulated by >1.5 fold in LOPE complicated pregnancies (p value <0.05) compared to controls. CONCLUSION: miR-23b-5p and miR-99b-5p are possibly implicated in the pathogenic mechanisms leading to the induction of LOPE and may serve as candidate non-invasive biomarkers for early prediction and prevention. +other 32871756 hsa-mir-23b Pre-Eclampsia RESULTS: miR-23b-5p and miR-99b-5p were down-regulated by >1.5 fold in LOPE complicated pregnancies (p value <0.05) compared to controls. CONCLUSION: miR-23b-5p and miR-99b-5p are possibly implicated in the pathogenic mechanisms leading to the induction of LOPE and may serve as candidate non-invasive biomarkers for early prediction and prevention. +other 32871753 hsa-mir-6072 Carcinoma, Hepatocellular Of these, miR-6072 and miR-3137 were significantly associated with a poor prognosis in HCC patients. +other 32871753 hsa-mir-137 Carcinoma, Hepatocellular Of these, miR-6072 and miR-3137 were significantly associated with a poor prognosis in HCC patients. +genetics_GWAS 32871665 hsa-mir-34a Depressive Disorder, Major METHODS: We selected several blood markers (global DNA methylation, and VEGF-a, TOLLIP, SIRT1, miR-34a genes) among factors that contribute to the pathogenetic mechanisms of MDD. miR-34a and SIRT1 levels were associated with MDD symptoms especially in early-life stressed patients. +exosome 32871496 hsa-mir-21 Breast Neoplasms The developed strategy allows discrimination of tumor cells and breast cancer patients by detecting exosomal miRNA-21, and the results of this biosensor are consistent with qRT-PCR. +lncRNA target 32871353 hsa-mir-562 psoriasis 1 Moreover, we found that circ_0003738 could bind to miR-562 to release the inhibition of target gene IL-17RA (IL-17 receptor A), thus promoting IL-17A signaling in psoriatic Tregs. +circulation_biomarker_diagnosis_ns 32871216 hsa-mir-433 Alzheimer Disease The decreased miR-433 expression levels in serum and cerebrospinal fluid (CS) were positively correlated with MMSE scores and had relatively high diagnostic accuracy in AD patients. +lncRNA target 32871166 hsa-mir-21 Glaucoma Thus, miR5p represents a new therapeutic strategy for glaucoma and a viable alternative to existing multidrug regimens. +lncRNA target 32871166 hsa-mir-21 Hyphema Transcriptome analysis and further quantification by Western blot and PCR revealed that SMAD7 and FGF18 might be the downstream target of miR +genetics_overexpression_promote 32871042 hsa-mir-148a Femur Head Necrosis Collectively, miR-148a-3p overexpressed in BMSC-EVs promoted SMAD7 and BCL2 expression by inhibiting SMURF1, thus alleviating ONFH. +transcription factor target 32870623 hsa-mir-542 Diabetic Retinopathy 5p may suppress apoptosis in retinal pigment epithelial cells via targeting CARM1, which provides a new therapeutic target for the treatment of patients with DR. +genetics_GWAS 32870579 hsa-mir-214 Osteosarcoma CONCLUSION: Our data provide new insights into the epigenetic axis of PWRN1/miR +transcription factor target 32870256 hsa-mir-183 Cardiomegaly Among them, miR-183 is well documented as a novel tumor suppressor in previous studies, whereas it exhibits a downregulated expression in cardiac hypertrophy recently. RESULTS: We observed a significant decreased expression of miR-183 in hypertrophic cardiomyocytes. +circRNA target 32869935 hsa-mir-326 Breast Neoplasms In this study, real-time polymerase chain reaction was employed to detect the circ_0000291 and miR-326 expressions in BC tissues and cells. In conclusion, circ_0000291 is the novel oncogenic circRNA and promotes BC progression via modulating the miR-326/ETS1 axis. +other 32869917 hsa-mir-4270 Diabetic Nephropathies The levels of miR-3137 and miR-4270 in DKD group were 0.670 /- 0.505 and 2.116 /- 1.762 times than those in DM group, respectively, showing great significance. CONCLUSION: MiR-3137 and miR-4270 show the potential for urinary biomarkers of DKD. +other 32869917 hsa-mir-137 Diabetic Nephropathies The levels of miR-3137 and miR-4270 in DKD group were 0.670 /- 0.505 and 2.116 /- 1.762 times than those in DM group, respectively, showing great significance. CONCLUSION: MiR-3137 and miR-4270 show the potential for urinary biomarkers of DKD. +other 32869899 hsa-mir-199a Osteoporosis This study indicates that miR-199a plays a critical role in preventing GC-mediated osteoblast differentiation and may function as a promising miRNA biomarker for osteoporosis. +other 32869899 hsa-mir-199a Corneal dystrophy, epithelial basement membrane This study indicates that miR-199a plays a critical role in preventing GC-mediated osteoblast differentiation and may function as a promising miRNA biomarker for osteoporosis. +lncRNA target 32869878 hsa-mir-497 Uterine Cervical Neoplasms 5p/CDC25A axis, which might be a promising target for CC treatments. +lncRNA target 32869851 hsa-mir-145 Breast Neoplasms These findings indicate that miR-145 is tumor suppressor miRNA, and may be a potential diagnostic and prognostic marker in breast cancer. +genetics_overexpression_promote 32869841 hsa-mir-205 Gallbladder Neoplasms The overexpression of miR +other 32869085 hsa-mir-24 Esophageal Atresia The levels of miRNA-21 and miRNA-24 in the EBC were analyzed by real-time polymerase chain reaction and compared between the EA group and the control group consisting of healthy children with no history of respiratory problems (n = 17). +other 32869085 hsa-mir-21 Esophageal Atresia EA patients with positive pH testing for GER (n = 6) and fundoplication (n = 6) had higher levels of miRNA-21 than those with normal pH testing and without fundoplication, respectively (n = 13, P < 0.05). The lower levels of miRNA-21 in the EBC of EA patients suggest a hyperreactive airway problem, which may be associated with GER and its surgical treatment. +genetics_knock down_promote 32868648 hsa-mir-337 Esophageal Squamous Cell Carcinoma TTTY15 could indirectly modulate JAK2, and overexpression of TTTY15 could reverse the inhibitory effects of miR +lncRNA target 32868489 hsa-mir-345 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma In conclusion, LncRNA CRNDE upregulated CREB expression by suppressing miR5p, thus promoting cell proliferation and reducing cell apoptosis in BCP-ALL. +transcription factor target 32868134 hsa-mir-20a Diabetic Nephropathies miR-20a was identified as an upstream regulatory miRNA of CXCL6, and its expression was decreased in DKD and HG-treated HK-2 cells. CONCLUSION: These consequences hinted that miR-20a might exert a repressive impact on DKD, possibly through targeting CXCL6 and mediating JAK/STAT3 pathway, which offer new targets for DKD treatment. +lncRNA target 32868080 hsa-mir-588 Osteosarcoma CONCLUSIONS: In summary, this study shows that LncRNA GSEC promotes the proliferation and invasion of OS through the regulation of miR-588/EIF5A2 pathway, which might provide a new strategy for the treatment of osteosarcoma in the future. +circulation_biomarker_diagnosis_down 32868076 hsa-mir-155 Diabetic Nephropathies RESULTS: The expression of CTBP1-AS2 was downregulated, and miR5p was highly expressed in peripheral blood of DN patients and HG-treated HGMCs. +genetics_knock down_suppress 32867570 hsa-mir-182 Esophageal Squamous Cell Carcinoma And silencing of miR-182 or overexpression of Myc effectively rescued the attenuated aggressive phenotype of ESCC cells caused by circ-LRP6 knockdown. Therefore, our data indicate that circ-LRP6 is a novel oncogenic circRNA in ESCC, targeting the circ-LRP6/miR-182/Myc signaling may be a promising therapeutic approach for ESCC patients. +other 32867562 hsa-mir-132 Alzheimer Disease miR-132 plays a critical role in regulating TAU protein levels and is important for preventing tau protein aggregation that causes Alzheimer's disease. +lncRNA target 32867454 hsa-mir-182 Esophageal Squamous Cell Carcinoma 5p is implicated in the carcinogenesis and development of ESCC, and thus may be a potential molecular target for ESCC patients. +other 32867322 hsa-mir-29a Autism Spectrum Disorde 5p, let-7b-5p, and miR-451a were downregulated in ASD compared to NUCs. +other 32867322 hsa-let-7b Autism Spectrum Disorde 5p, let-7b-5p, and miR-451a were downregulated in ASD compared to NUCs. +other 32867322 hsa-mir-141 Autism Spectrum Disorde 5p, let-7b-5p, and miR-451a were downregulated in ASD compared to NUCs. +other 32867322 hsa-mir-16 Autism Spectrum Disorde 5p, let-7b-5p, and miR-451a were downregulated in ASD compared to NUCs. +circulation_biomarker_diagnosis_up 32867069 hsa-mir-193a Melanoma METHODS: After observing the reduced levels of miR-193a arms in plasma exosomes of melanoma patients, the effects of hsa-miR-193a-3p and -5p transfection in cutaneous melanoma cell lines are investigated. CONCLUSIONS: Our results underline a relevant role of miR-193a, both -3p and -5p, as tumor suppressors clarifying the intracellular mechanisms involved and suggesting that their ectopic over-expression could represent a novel treatment for cutaneous melanoma patients. +other 32866906 hsa-mir-142 Triple Negative Breast Neoplasms The correlations among p300 abundances, miR3p levels, PSMB5 expressions, and the CT-l activities of 20S proteasome were evidenced in TNBC tissues. +lncRNA target 32866662 hsa-mir-708 Coronary Artery Disease Together, these data indicate that miR-708 may protect against H/R-induced cardiomyocyte damage by directing targeting HMGB1 signaling, implying a promising therapeutic agent against ischemic heart disease including myocardial infarction. +lncRNA target 32866662 hsa-mir-708 Myocardial Infarction Together, these data indicate that miR-708 may protect against H/R-induced cardiomyocyte damage by directing targeting HMGB1 signaling, implying a promising therapeutic agent against ischemic heart disease including myocardial infarction. +lncRNA target 32866660 hsa-mir-760 Carcinoma, Non-Small-Cell Lung In conclusion, a new mechanism was revealed, wherein PVT1 regulates NSCLC cell migration and invasion via miR-760/IL-6, suggesting PVT1/miR-760/IL-6 as promising prognostic biomarkers and therapeutic targets for NSCLC metastasis. +other 32866518 hsa-mir-23a Pneumonia, Mycoplasma We found that HDAC2 was poorly expressed in placental tissue samples from PE pregnant women, and its expression correlated inversely with miR-23a expression. +transcription factor target 32866518 hsa-mir-23b Pneumonia, Mycoplasma In summary, these results support a novel role of miR-23b in invasion and apoptosis of trophoblast cells, and imply that targeting miR-23b may be a new avenue for treating PE. +circulation_biomarker_diagnosis_ns 32866261 hsa-mir-378a Vascular Calcification Adding serum miR-125b +circulation_biomarker_diagnosis_ns 32866261 hsa-mir-125b-2 Vascular Calcification Adding serum miR-125b +genetics_overexpression_promote 32865704 hsa-mir-361 Retinoblastoma 3p specifically bound to WNT3A, and overexpression of miR +other 32865618 hsa-mir-7 Carcinoma, Squamous Cell 5p are involved in a UV-driven pathway of progression to metastasis. +other 32865618 hsa-mir-29a Carcinoma, Squamous Cell 5p are involved in a UV-driven pathway of progression to metastasis. +other 32865618 hsa-mir-183 Carcinoma, Squamous Cell 5p are involved in a UV-driven pathway of progression to metastasis. +circulation_biomarker_prognosis_up 32865353 hsa-mir-1290 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS The expression level of plasma miR-1290 in patients with OSCC significantly decreased, and the low expression of miR-1290 is related to the short survival time of OSCC patients. +genetics_knock down_suppress 32865180 hsa-mir-133b Colorectal Neoplasms Our current work had led to the identification of circ_0007031 knockdown that repressed CRC cell malignant progression and enhanced 5-FU sensitivity via regulating ABCC5 expression by sponging miR-133b. +circulation_biomarker_diagnosis_up 32865178 hsa-mir-186 Osteosarcoma Subsequently, we disclosed that DSCAM-AS1 was mainly observed in the cytoplasm of OS cells and could bind with miR +genetics_overexpression_promote 32864914 hsa-mir-132 Melanoma SNHG16 was overexpressed, and miR-132 was low expressed in melanoma tissues and cell lines. +lncRNA target 32864822 hsa-mir-22 Cardiomyopathies 5p, causing changes in its target gene Rap1a and the RAP1/ERK pathway. +target gene 32864009 hsa-mir-24 Lung Neoplasms LncRNA PCAT-1 upregulates RAP1A through modulating miR-324-5p and promotes survival in lung cancer. +lncRNA target 32864006 hsa-mir-30 Glioma 3p inhibited the propagation and migration of glioma cells by repressing CELF1 expression. +tissue_expression_down 32864004 hsa-mir-1255b Carcinoma, Hepatocellular In HCC, hsa-miR-15b (p = 0.0010), hsa-miR-125b (p = 0.0010), hsa-miR3p (p = 0.0010), hsa-miR-424 (p = 0.0313), hsa-miR-494 (p < 0.0001), hsa-miR-497 (p < 0.0001), hsa-miR-612 (p = 0.0078), hsa-miR-637 (p < 0.0001), and hsa-miR-1255b (p = 0.0156) presented down-expression. +tissue_expression_down 32864004 hsa-mir-612 Carcinoma, Hepatocellular In HCC, hsa-miR-15b (p = 0.0010), hsa-miR-125b (p = 0.0010), hsa-miR3p (p = 0.0010), hsa-miR-424 (p = 0.0313), hsa-miR-494 (p < 0.0001), hsa-miR-497 (p < 0.0001), hsa-miR-612 (p = 0.0078), hsa-miR-637 (p < 0.0001), and hsa-miR-1255b (p = 0.0156) presented down-expression. +tissue_expression_down 32864004 hsa-mir-15b Carcinoma, Hepatocellular In HCC, hsa-miR-15b (p = 0.0010), hsa-miR-125b (p = 0.0010), hsa-miR3p (p = 0.0010), hsa-miR-424 (p = 0.0313), hsa-miR-494 (p < 0.0001), hsa-miR-497 (p < 0.0001), hsa-miR-612 (p = 0.0078), hsa-miR-637 (p < 0.0001), and hsa-miR-1255b (p = 0.0156) presented down-expression. +tissue_expression_down 32864004 hsa-mir-424 Carcinoma, Hepatocellular In HCC, hsa-miR-15b (p = 0.0010), hsa-miR-125b (p = 0.0010), hsa-miR3p (p = 0.0010), hsa-miR-424 (p = 0.0313), hsa-miR-494 (p < 0.0001), hsa-miR-497 (p < 0.0001), hsa-miR-612 (p = 0.0078), hsa-miR-637 (p < 0.0001), and hsa-miR-1255b (p = 0.0156) presented down-expression. +tissue_expression_down 32864004 hsa-mir-497 Carcinoma, Hepatocellular In HCC, hsa-miR-15b (p = 0.0010), hsa-miR-125b (p = 0.0010), hsa-miR3p (p = 0.0010), hsa-miR-424 (p = 0.0313), hsa-miR-494 (p < 0.0001), hsa-miR-497 (p < 0.0001), hsa-miR-612 (p = 0.0078), hsa-miR-637 (p < 0.0001), and hsa-miR-1255b (p = 0.0156) presented down-expression. +tissue_expression_down 32864004 hsa-mir-125b Carcinoma, Hepatocellular In HCC, hsa-miR-15b (p = 0.0010), hsa-miR-125b (p = 0.0010), hsa-miR3p (p = 0.0010), hsa-miR-424 (p = 0.0313), hsa-miR-494 (p < 0.0001), hsa-miR-497 (p < 0.0001), hsa-miR-612 (p = 0.0078), hsa-miR-637 (p < 0.0001), and hsa-miR-1255b (p = 0.0156) presented down-expression. +transcription factor target 32864001 hsa-mir-214 Myocardial Reperfusion Injury 5p exerted a protective role in I/R injured cardiac cells by direct targeting FASLG in vitro and in vivo. +exosome 32863945 hsa-mir-146a Reperfusion Injury, Renal Ischemia Conclusions: According to our experimental results, USCs could protect against renal IRI via exosomal miR-146a-5p, which could target the 3'UTR of IRAK1 and subsequently inhibit the activation of NF-kappaB signaling and infiltration of inflammatory cells to protect renal function. +target gene 32863933 hsa-mir-424 Colorectal Neoplasms miR-424-5p is a potential target in the treatment of CRC. +genetics_overexpression_promote 32863913 hsa-mir-375 Squamous Cell Carcinoma of Head and Neck Consistent with the role of HNF1beta in glucose metabolism, overexpression of miR +genetics_overexpression_promote 32863912 hsa-mir-144 Osteosarcoma Expression of ZNF281 and miR-144 resulted in decreased cell migration and invasion, while ROCK1 overexpression resulted in increased invasion and migration of OS cells. +transcription factor target 32863907 hsa-mir-642a Carcinoma, Hepatocellular Briefly, miR-642a targeted SEMA4C to repress HCC cell migration and invasion through p38 MAPK signaling pathway providing a new strategy for treatment of HCC patients. +transcription factor target 32863902 hsa-mir-548ac Squamous Cell Carcinoma of Head and Neck Taken together, the present results suggest that miR-548ac functions as a crucial cancer suppressor in laryngeal cancer, which induces apoptosis in laryngeal cancer cells by suppressing TMEM158. Thus, miR-548ac may be a potential target for the treatment of laryngeal cancer. +transcription factor target 32863902 hsa-mir-548 Squamous Cell Carcinoma of Head and Neck Taken together, the present results suggest that miR-548ac functions as a crucial cancer suppressor in laryngeal cancer, which induces apoptosis in laryngeal cancer cells by suppressing TMEM158. Thus, miR-548ac may be a potential target for the treatment of laryngeal cancer. +lncRNA target 32863773 hsa-mir-411 Squamous Cell Carcinoma of Head and Neck CONCLUSION: lncRNA TTN-AS1 contributed to the progression of OSCC via miR +transcription factor target 32863772 hsa-mir-214 Carcinoma, Non-Small-Cell Lung 3p plays a pivotal role in CSCs properties by targeting YAP1, which provides a potential treatment strategy for LSCC patients. +circRNA target 32863771 hsa-mir-182 Endometrial Neoplasms CONCLUSION: Our results confirmed that circ_0001776 inhibited EC tumorigenesis and progression via miR-182/LRIG2 axis, providing a potential therapeutic target for EC. +transcription factor target 32863766 hsa-mir-182 Squamous Cell Carcinoma of Head and Neck 3p, and its silencing could reverse the inhibition of miR +genetics_knock down_suppress 32863763 hsa-mir-326 Carcinoma, Hepatocellular CONCLUSION: circ_0000517 knockdown repressed hepatocellular carcinoma development in vitro and in vivo by modulating miR-326 and IGF1R. +other 32863323 hsa-mir-887 Breast Neoplasms Moreover, results indicated that miR-720 and miR-887 are expressed at relatively high levels in breast cancer cell lines compared to other types of cancer. +lncRNA target 32862616 hsa-mir-130a Urinary Bladder Neoplasms PURPOSE: The study aimed to explore the regulatory mechanism of micro ribonucleic acid (miR)-130a in the autophagy of bladder cancer cells through cylindromatosis (CYLD). CONCLUSION: MiR-130 can promote the autophagy of bladder cancer cells through regulating CYLD, thus facilitating the proliferation of tumor cells. +tissue_expression_ns 32862613 hsa-mir-92a Prostatic Neoplasms Associations between the expressions of MiR-135 and MiR-92a and pathogenesis of prostate cancer and analysis of their clinical significance. PURPOSE To explore the associations between the expressions of micro ribonucleic acid (miR)-135 and miR-92a and the pathogenesis of prostate cancer, as well as their clinical significance. The associations of expressions of miR-135 and miR-92a with the pathological Gleason score and expression of prostate specific antigen (PSA) were assessed, the sensitivity and specificity of miR-135 and miR-92a in the diagnosis of prostate cancer were compared, and the associations between the expressions of miR-135 and miR-92a and the prognosis of prostate cancer patients were evaluated. CONCLUSIONS The expressions of miR-135 and miR-92a are of certain value in screening prostate cancer. +lncRNA target 32862612 hsa-mir-16 Leukemia The qRT-PCR analysis showed that microRNA (miR)-16 was significantly (p<0.05) downregulated in leukemia AML-193 cells as compared to normal NCI-H526 cells. CONCLUSION: Taken together, these results showed that Solanine inhibits the proliferation of leukemia cells via induction of apoptosis and modulation of miR-16/Bcl-2 axis. +genetics_overexpression_promote 32862607 hsa-mir-215 Nasopharyngeal Carcinoma Cell proliferation, migration and invasion were promoted by overexpression of miR-215 in NPC. +genetics_overexpression_promote 32862605 hsa-mir-432 Osteosarcoma RESULTS: miR-423 and miR-548c-3p showed low expression in osteosarcoma, and the overexpression of miR-432 and miR-548c-3p in osteosarcoma cells could inhibit the proliferation of tumor cells and promote their apoptosis. +genetics_overexpression_promote 32862605 hsa-mir-548c Osteosarcoma RESULTS: miR-423 and miR-548c-3p showed low expression in osteosarcoma, and the overexpression of miR-432 and miR-548c-3p in osteosarcoma cells could inhibit the proliferation of tumor cells and promote their apoptosis. +genetics_overexpression_promote 32862599 hsa-mir-1203 Carcinoma, Non-Small-Cell Lung The inhibitory effects of LINC00632 on cell growth and metastasis in NSCLC were abolished by overexpression of miR-1203 levels. +circulation_biomarker_diagnosis_up 32862588 hsa-mir-21 Colorectal Neoplasms CONCLUSIONS: Serum microRNA-18a and/or microRNA-21 might serve as non-invasive diagnostic markers in colorectal cancer, while serum microRNA-92a is better to be combined with either microRNA-18a or microRNA-21 as it has limited usefulness when used as sole diagnostic marker. +circulation_biomarker_diagnosis_up 32862588 hsa-mir-92a Colorectal Neoplasms CONCLUSIONS: Serum microRNA-18a and/or microRNA-21 might serve as non-invasive diagnostic markers in colorectal cancer, while serum microRNA-92a is better to be combined with either microRNA-18a or microRNA-21 as it has limited usefulness when used as sole diagnostic marker. +circulation_biomarker_diagnosis_up 32862588 hsa-mir-18a Colorectal Neoplasms CONCLUSIONS: Serum microRNA-18a and/or microRNA-21 might serve as non-invasive diagnostic markers in colorectal cancer, while serum microRNA-92a is better to be combined with either microRNA-18a or microRNA-21 as it has limited usefulness when used as sole diagnostic marker. +lncRNA target 32862579 hsa-mir-449a Carcinoma, Hepatocellular CONCLUSION: miR-449a can inhibit the proliferation and invasion of HCC cells and promote their apoptosis through the targeted regulation of SATB1, so it is expected to become a potential therapeutic target for this disease in clinical practice. +genetics_knock down_promote 32862492 hsa-mir-194 Urinary Bladder Neoplasms Cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) were detected to assess the influences of ZNRD1-AS1, miR-194 and ZEB1 on BC cells by colony formation, cell counting kit-8 (CCK-8), transwell analysis or western blot. CONCLUSION: Knockdown of ZNRD1-AS1 suppressed BC cell development in vitro and in vivo via targeting miR-194 to regulate ZEB1, indicating a novel avenue for treatment of BC. +genetics_GWAS 32862489 hsa-mir-212 Stomach Neoplasms CONCLUSION: Our study demonstrated that miR-212 was epigenetically downregulated in gastric cancer, and resulting low level of miR-212 can be a potential circulating biomarker and poor prognosis predicator of gastric cancer. +genetics_knock down_promote 32862055 hsa-mir-140 Esophageal Neoplasms ZEB2 overexpression reversed the effects of miR-140 on proliferation, apoptosis, migration, and invasion of esophageal cancer cells. +lncRNA target 32861958 hsa-mir-16 Pelizaeus-Merzbacher Disease As the let-7e and miR-16 miRNAs were used as internal controls for the bone tissue in previous studies, these miRNAs were selected as targets to estimate PMI. +lncRNA target 32861958 hsa-let-7e Pelizaeus-Merzbacher Disease As the let-7e and miR-16 miRNAs were used as internal controls for the bone tissue in previous studies, these miRNAs were selected as targets to estimate PMI. +epigenetics 32861793 hsa-mir-152 Urinary Bladder Neoplasms SIGNIFICANCE: This study confirmed the role and underlying mechanism of DNMT1-mediated DNA methylation and displayed a novel regulatory pathway miR-152/DNMT1/PTEN in BCa, thus, providing a potential diagnostic and therapeutic targets for BCa. +genetics_overexpression_suppress 32861705 hsa-mir-7 Glioblastoma In contrast to miR-7, TBX2 had an increased expression in GBM tumors and was linked to poor prognosis. Our findings demonstrated that overexpression of TBX2 in GBM tumors via the downregulation of miR-7 leads to EMT induction and increased cell invasion. +lncRNA target 32861626 hsa-mir-129 Osteomyelitis 5p/eNOS in the pathogenesis of osteomyelitis, which may also serve as therapeutic targets. +other 32861171 hsa-mir-192 Osteosarcoma Collectively, our results elucidated that miR-192 contributes to chemo-sensitizing MG-63 cells to MTX, and could be considered as a promising agent to overcome MTX-resistance in OS. +other 32861171 hsa-mir-192 Myasthenia Gravis Collectively, our results elucidated that miR-192 contributes to chemo-sensitizing MG-63 cells to MTX, and could be considered as a promising agent to overcome MTX-resistance in OS. +transcription factor target 32861000 hsa-mir-192 Prosthesis Failure In this study, through small RNA sequencing analysis, we showed that a low level of miR +circRNA target 32860985 hsa-mir-424 Angelman Syndrome CONCLUSION: Circ_0029589 silence might inhibit the progression of AS by regulating miR5p/IGF2 axis, providing a novel mechanism for pathogenesis of AS. +other 32860924 hsa-mir-34a Colorectal Neoplasms The CS/LaP/siEGFR NPs exhibited significant biological activities in human colorectal cancer HT-29 cells by the synergistic effects of siEGFRs and lanthanum ions, such as downregulation of EGFR and upregulation of miR-34a. +genetics_knock down_promote 32860901 hsa-mir-151a Neuralgia We displayed that miR-151a-3p was greatly reduced in CCI rats and circ_0005075 reversed the repressive effect of miR-151a-3p on neuropathic pain. To sum up, we indicated that loss ofcirc_0005075relieved neuropathic pain progression by inducement of miR-151a-3p and inactivation of NOTCH2 signaling. +lncRNA target 32860899 hsa-mir-17 Diabetic Nephropathies Further investigations revealed that AKT3 was the putative target of miR +other 32860827 hsa-mir-92b Atrial Premature Complexes Overall, this work demonstrates the usefulness of the microfluidic platform based on the pre-miR-92b to detect NCL and the possibility to be used as a valuable biomedical tool in PCa diagnosis. +other 32860827 hsa-mir-92b Neuronal Ceroid-Lipofuscinoses Overall, this work demonstrates the usefulness of the microfluidic platform based on the pre-miR-92b to detect NCL and the possibility to be used as a valuable biomedical tool in PCa diagnosis. +genetics_knock down_suppress 32860757 hsa-mir-876 Carcinoma, Hepatocellular 3p and enhanced by the knockdown of miR +other 32860610 hsa-mir-155 Multiple Sclerosis The aim of this study was to investigate the effect of HCQ on miR-219 and miR3p expression changes in MS-induced model. +other 32860610 hsa-mir-219 Multiple Sclerosis The aim of this study was to investigate the effect of HCQ on miR-219 and miR3p expression changes in MS-induced model. +lncRNA target 32860589 hsa-mir-216a Squamous Cell Carcinoma of Head and Neck We concluded that DANCR may promote the growth and metastasis of OSCC cells and suppress OSCC cell apoptosis by sponging miR-216a-5p. +other 32860508 hsa-mir-874 Colorectal Neoplasms Collectively, these outcomes highlighted that MCF2L-AS1 acted as a motivator by modulating the miR3p/FOXM1 axis, thereby aggravating tumorigenesis and glycolysis progress of CRC, disclosing that MCF2L-AS1 may serve as a valuable and promising therapeutic strategy for CRC. +exosome 32860495 hsa-mir-410 Intervertebral Disc Degeneration Finally, we presented evidence that MSCs-derived exosomal miR-410 was a crucial regulator of pyroptosis. +other 32860338 hsa-mir-136 Parkinson Disease 5p, and miR-323a-3p levels were found to be differentially expressed between healthy controls and PD patients. +other 32860338 hsa-mir-154 Parkinson Disease 5p, and miR-323a-3p levels were found to be differentially expressed between healthy controls and PD patients. +other 32860338 hsa-mir-22 Parkinson Disease 5p, and miR-323a-3p levels were found to be differentially expressed between healthy controls and PD patients. +other 32860338 hsa-mir-23a Parkinson Disease 5p, and miR-323a-3p levels were found to be differentially expressed between healthy controls and PD patients. +other 32860338 hsa-mir-124 Parkinson Disease 5p, and miR-323a-3p levels were found to be differentially expressed between healthy controls and PD patients. +lncRNA target 32860321 hsa-mir-588 Carcinoma, Hepatocellular PICSAR played an oncogenic role by targeting miR-588 and subsequently promoted EIF6 expression and PI3K/AKT/mTOR activation in HCC. +other 32860308 hsa-mir-1227 Lung Neoplasms Together, our data indicated that Spt16 is likely to be an essential regulator for lung cancer malignancy and is negatively regulated by miR5p. +lncRNA target 32860283 hsa-mir-1269a Stomach Neoplasms The RP11-1094M14.8/miR-1269a/CXCL9 axis may serve as a potential immune-therapeutic target for gastric cancer with different degrees of immune cell infiltration. +genetics_knock down_suppress 32859986 hsa-mir-124 Colorectal Neoplasms Knockdown of miR +other 32859747 hsa-mir-29 Constriction, Pathologic miR21-3p, miR29-3p, and miR26a were upregulated in stenotic vessels compared with non-stenotic vessels after SR thrombectomy (P<0.001). +other 32859747 hsa-mir-21 Constriction, Pathologic miR21-3p, miR29-3p, and miR26a were upregulated in stenotic vessels compared with non-stenotic vessels after SR thrombectomy (P<0.001). +other 32859747 hsa-mir-26a Constriction, Pathologic miR21-3p, miR29-3p, and miR26a were upregulated in stenotic vessels compared with non-stenotic vessels after SR thrombectomy (P<0.001). +other 32859639 hsa-let-7c Colorectal Neoplasms The aim of the study was to evaluate the association of response to anti-EGFR monoclonal antibodies (mAbs) with selected miR expression profiles, including miR-125b, let-7c, miR-99a, miR-17, miR-143 and miR-145 in metastatic colorectal cancer (mCRC) patients. CONCLUSION The results show that up-regulation of miR-125b is associated with higher ORR and DCR and longer survival; let-7c up-regulation and miR-17 down-regulation are associated with higher DCR in mCRC patients treated with anti-EGFR mAbs. +other 32859639 hsa-mir-125b Colorectal Neoplasms The aim of the study was to evaluate the association of response to anti-EGFR monoclonal antibodies (mAbs) with selected miR expression profiles, including miR-125b, let-7c, miR-99a, miR-17, miR-143 and miR-145 in metastatic colorectal cancer (mCRC) patients. CONCLUSION The results show that up-regulation of miR-125b is associated with higher ORR and DCR and longer survival; let-7c up-regulation and miR-17 down-regulation are associated with higher DCR in mCRC patients treated with anti-EGFR mAbs. +other 32859639 hsa-mir-17 Colorectal Neoplasms The aim of the study was to evaluate the association of response to anti-EGFR monoclonal antibodies (mAbs) with selected miR expression profiles, including miR-125b, let-7c, miR-99a, miR-17, miR-143 and miR-145 in metastatic colorectal cancer (mCRC) patients. CONCLUSION The results show that up-regulation of miR-125b is associated with higher ORR and DCR and longer survival; let-7c up-regulation and miR-17 down-regulation are associated with higher DCR in mCRC patients treated with anti-EGFR mAbs. +genetics_overexpression_promote 32859232 hsa-mir-211 Carcinoma, Hepatocellular 5p overexpression impaired tumorigenesis and growth of HCC in vivo. +other 32858559 hsa-mir-125b Ossification, Heterotopic RESULTS: The investigation of the miRNA expression profile in the tissue of HO+ compared with HO- patients demonstrated a molecular signature that included the upregulation of miR-1, miR-133a, miR-133b, miR-206, miR-26a, and miR-125b. +other 32858559 hsa-mir-133a Ossification, Heterotopic RESULTS: The investigation of the miRNA expression profile in the tissue of HO+ compared with HO- patients demonstrated a molecular signature that included the upregulation of miR-1, miR-133a, miR-133b, miR-206, miR-26a, and miR-125b. +other 32858559 hsa-mir-1 Ossification, Heterotopic RESULTS: The investigation of the miRNA expression profile in the tissue of HO+ compared with HO- patients demonstrated a molecular signature that included the upregulation of miR-1, miR-133a, miR-133b, miR-206, miR-26a, and miR-125b. +other 32858559 hsa-mir-26a Ossification, Heterotopic RESULTS: The investigation of the miRNA expression profile in the tissue of HO+ compared with HO- patients demonstrated a molecular signature that included the upregulation of miR-1, miR-133a, miR-133b, miR-206, miR-26a, and miR-125b. +other 32858559 hsa-mir-206 Ossification, Heterotopic RESULTS: The investigation of the miRNA expression profile in the tissue of HO+ compared with HO- patients demonstrated a molecular signature that included the upregulation of miR-1, miR-133a, miR-133b, miR-206, miR-26a, and miR-125b. +other 32858559 hsa-mir-133b Ossification, Heterotopic RESULTS: The investigation of the miRNA expression profile in the tissue of HO+ compared with HO- patients demonstrated a molecular signature that included the upregulation of miR-1, miR-133a, miR-133b, miR-206, miR-26a, and miR-125b. +exosome 32858458 hsa-mir-141 Intervertebral disc disease Exosomal circRNA_0000253 owns the maximum upregulation in degenerative NPC exosomes and could promote IDD by adsorbing miRNA +exosome 32858458 hsa-mir-141 Nasopharyngeal Carcinoma Exosomal circRNA_0000253 owns the maximum upregulation in degenerative NPC exosomes and could promote IDD by adsorbing miRNA5p and downregulating SIRT1. +lncRNA target 32858372 hsa-mir-512 Carcinoma, Non-Small-Cell Lung 5p, and NCK1-AS1 could up-regulate the expression of p21 in NSCLC cells via repressing miR +other 32858253 hsa-mir-31 Osteomyelitis After validation experiments, miRNA3p and fibroblast growth factor 23 (FGF23) were found to be inversely correlated with the pathways of osteoblast mineralization and pathology of infected bone nonunion. +genetics_knock down_promote 32858123 hsa-mir-9 Glioma Gain and loss of function of small nucleolar RNA host gene 1 (SNHG1) and miR +lncRNA target 32858006 hsa-mir-29a Squamous Cell Carcinoma of Head and Neck In this study, we investigated the tumor suppressive role of miRNA-29a in laryngeal squamous cell carcinoma. Taken together, our data suggest that miR-29a functions as a tumor suppressor through targeting STAT3 in laryngeal squamous cell carcinoma. +lncRNA target 32857725 hsa-mir-520c Cholangiocarcinoma SP1/HOXD-AS1/miR-520c-3p/MYCN plays a vital role in initiation and progression of CCA, and HOXD-AS1 is expected to be an efficient biomarker and therapeutic target. +lncRNA target 32857667 hsa-mir-455 Lung Neoplasms Collectively, propofol suppressed cell carcinogenesis and aerobic glycolysis by regulating circTADA2A/miR +lncRNA target 32857606 hsa-mir-548a Colonic Neoplasms Conclusion: This study revealed that miR-548a-3p attenuated the development of CC by targeting TPX2. +genetics_overexpression_promote 32857295 hsa-mir-375 Neuroblastoma Also, L1CAM overexpression reversed the effects of miR-375 enhancement on the cell cycle progression, proliferation, and radiosensitivity of NB cells. +circulation_biomarker_diagnosis_up 32856980 hsa-mir-371a Testicular Germ Cell Tumor Performance characteristics of serum miR-371a-3p were compared with conventional serum tumor markers (-fetoprotein/beta-human chorionic gonadotropin/lactate dehydrogenase) between patients with viable germ cell tumor and those without viable germ cell tumor on orchiectomy pathology. +genetics_GWAS 32856881 hsa-mir-375 Breast Neoplasms This study has been performed to investigate the relationship between polymorphisms of rs6715345 of miR-375 gene and rs4939827 of the SMAD7 gene and development of breast cancer in a population in southeastern Iran. RESULTS: The findings of this study indicated that the risk of developing breast cancer does not have a significant relationship with rs6715345 polymorphism of miR-375 gene (p=0.1). +lncRNA target 32856736 hsa-mir-34a Pituitary Neoplasms Thus, miR-34a is a novel downstream target of mutant AIP that promotes a cellular phenotype mirroring the aggressive clinical features of AIPmut+ acromegaly. +lncRNA target 32856542 hsa-mir-199a Uterine Cervical Neoplasms Quantitative real-time polymerase chain reaction and western blot results indicated that microRNA-199a inhibits tumor progression in cervical cancer by targeting B7-H3. +genetics_overexpression_promote 32856394 hsa-mir-362 Thyroid Neoplasms 5p upregulation reversed the effect of GAS5, and SMG1 overexpression eliminated the impact of miR +genetics_knock down_promote 32856377 hsa-mir-27b Osteoarthritis To further explore the miR-27b-3p functions in OA, western blot analysis, enzyme-linked immunosorbent assay, and beta-galactosidase activity assay were conducted with the results showing that knockdown of miR-27b-3p promoted expression of the osteogenic differentiation markers while inhibiting expression of the adipogenic differentiation markers, inflammatory factors, and cellular senescence of bone marrow mesenchymal stem cells (BMSCs). +genetics_overexpression_suppress 32856218 hsa-mir-942 Carcinoma, Hepatocellular 5p overexpression reversed the inhibitory effect of circ_0001445 on HCC cell progression. +other 32855967 hsa-mir-1200 Stomach Neoplasms miR-1200/POLD4 pathway mediated the promoting role of circ_0026359 in CDDP resistance of gastric cancer. +other 32855961 hsa-mir-376a Atherosclerosis Furthermore, our results also indicated that miRNA-130a-3p and miRNA-376a-3p were novel players in the regulation of TCDD- and Aroclor1254-induced atherosclerosis pathways. +other 32855961 hsa-mir-130a Atherosclerosis Furthermore, our results also indicated that miRNA-130a-3p and miRNA-376a-3p were novel players in the regulation of TCDD- and Aroclor1254-induced atherosclerosis pathways. +circulation_biomarker_diagnosis_ns 32855824 hsa-mir-451 Diabetic Nephropathies Both plasma and urinary microRNA-451 are highly sensitive and specific markers for chronicity in diabetic nephropathy patients with sensitivity of 90.9% and 95.5% and specificity of 67.6% and 95.6%, respectively. +genetics_knock down_suppress 32855738 hsa-mir-150 Cognition Disorders Furthermore, the overexpression of miR-150 alleviated the isoflurane-induced cognitive dysfunction and neuroinflammation, while the neuroprotective effects of TMP were significantly abrogated by the knockdown of miR-150. +circulation_biomarker_diagnosis_down 32855736 hsa-mir-186 Carcinoma, Hepatocellular In conclusion, VEGF was significantly increased in tumor thrombus and blood samples from HCC patients with vein tumor thrombus, which may be associated with the downregulation of miR-186. +other 32855723 hsa-mir-130b Carcinoma, Non-Small-Cell Lung Kaplan-Meier survival analysis indicated that the expression of ubiquitin E2 ligase C, cell division cycle protein 20, DNA topoisomerase IIalpha, aurora kinase A and B, cyclin B2, maternal embryonic leucine zipper kinase, slit guidance ligand 3, phosphoglucomutase 5, endomucin, cysteine dioxygenase type 1, dihydropyrimidinase-like 2, miR-130b, miR-1181 and miR-127 was significantly associated with overall survival of patients with lung adenocarcinoma. +other 32855723 hsa-mir-1181 Carcinoma, Non-Small-Cell Lung Kaplan-Meier survival analysis indicated that the expression of ubiquitin E2 ligase C, cell division cycle protein 20, DNA topoisomerase IIalpha, aurora kinase A and B, cyclin B2, maternal embryonic leucine zipper kinase, slit guidance ligand 3, phosphoglucomutase 5, endomucin, cysteine dioxygenase type 1, dihydropyrimidinase-like 2, miR-130b, miR-1181 and miR-127 was significantly associated with overall survival of patients with lung adenocarcinoma. +other 32855723 hsa-mir-127 Carcinoma, Non-Small-Cell Lung Kaplan-Meier survival analysis indicated that the expression of ubiquitin E2 ligase C, cell division cycle protein 20, DNA topoisomerase IIalpha, aurora kinase A and B, cyclin B2, maternal embryonic leucine zipper kinase, slit guidance ligand 3, phosphoglucomutase 5, endomucin, cysteine dioxygenase type 1, dihydropyrimidinase-like 2, miR-130b, miR-1181 and miR-127 was significantly associated with overall survival of patients with lung adenocarcinoma. +circulation_biomarker_diagnosis_up 32855708 hsa-mir-155 Uremia Reverse transcription quantitative PCR was used to detect the serum miR-155 levels of all the subjects in the two groups before treatment and those of uremia patients after treatment. +circulation_biomarker_diagnosis_up 32855704 hsa-mir-409 Diabetes, Gestational 5p is highly expressed in the serum of patients with GDM, and it is positively correlated with insulin resistance index of GDM patients, which may be a potential target for clinical diagnosis and treatment of GDM. +target gene 32855702 hsa-mir-193b Ovarian Neoplasms MicroRNA-193b regulates human ovarian cancer cell growth via targeting STMN1. +other 32855691 hsa-mir-770 Iris Diseases 5p. +circulation_biomarker_diagnosis_ns 32855688 hsa-mir-27b Pulmonary Arterial Hypertension The patients with CHD-PAH showed higher serum miR-27b, BNP and ADMA but lower miR-451 than the controls. +circulation_biomarker_diagnosis_ns 32855688 hsa-mir-451 Pulmonary Arterial Hypertension The patients with CHD-PAH showed higher serum miR-27b, BNP and ADMA but lower miR-451 than the controls. +lncRNA target 32855680 hsa-mir-1 Acute Kidney Injury Taken together, the results of the present study suggest that puerarin exhibits a renal protective effect against DDP-induced AKI by upregulating miR-31 expression and inhibiting the Numb/Notch1 signaling pathway. +other 32855677 hsa-mir-124 Pulmonary Fibrosis Moreover, RT-qPCR results indicated that miR-124, hsa-miR5p, hsa-miR-194 and hsa-miR-133a were differentially expressed between patients with IPF and age-matched men without fibrotic lung disease. +other 32855677 hsa-mir-524 Pulmonary Fibrosis Moreover, RT-qPCR results indicated that miR-124, hsa-miR5p, hsa-miR-194 and hsa-miR-133a were differentially expressed between patients with IPF and age-matched men without fibrotic lung disease. +other 32855677 hsa-mir-194 Pulmonary Fibrosis Moreover, RT-qPCR results indicated that miR-124, hsa-miR5p, hsa-miR-194 and hsa-miR-133a were differentially expressed between patients with IPF and age-matched men without fibrotic lung disease. +lncRNA target 32855660 hsa-mir-652 Osteosarcoma Treatment with KLF9 small interfering RNA abolished the suppression of OS proliferation and invasion induced by miR-652 downregulation. +other 32855642 hsa-mir-143 Cardiomyopathies RESULTS: The two transgenic lines showed dilated cardiomyopathy-like characteristics and early lethality with markedly increased expression of miR-143. +genetics_overexpression_suppress 32855642 hsa-mir-145 Cardiomyopathies CONCLUSIONS: Overexpression of miR-143 and miR-145 leads to a unique dilated cardiomyopathy phenotype with a reductive redox shift despite marked downregulation of HK2 expression. +lncRNA target 32855634 hsa-mir-3200 Stomach Neoplasms CONCLUSION: Silencing of LINC00324 inhibited the proliferation, migration, and invasion of GC cells through regulating the miR +lncRNA target 32855541 hsa-mir-30 Pancreatic Carcinoma Taken together, circSFMBT1 promotes proliferation and metastasis of PC via regulating miR +exosome 32855524 hsa-mir-21 Carcinoma, Lewis Lung In addition, our data showed that exosomes derived from human lung cancer cell lines expressing miR-21a, also induced expansion of MDSCs in human CD14(+) monocytes in vitro. Overall, our results demonstrated that miR-21a enriched in lung carcinoma cell-derived exosomes could promote functional expansion of MDSCs through targeting PDCD4. +other 32854743 hsa-mir-766 Carcinoma, Ovarian Epithelial 3p were found statically significant. +other 32854743 hsa-mir-1305 Carcinoma, Ovarian Epithelial 3p were found statically significant. +other 32854743 hsa-mir-651 Carcinoma, Ovarian Epithelial 3p were found statically significant. +other 32854743 hsa-mir-766 Ovarian Neoplasms 3p were found statically significant. +other 32854743 hsa-mir-1305 Ovarian Neoplasms 3p were found statically significant. +other 32854743 hsa-mir-651 Ovarian Neoplasms 3p were found statically significant. +other 32854743 hsa-mir-4430 Ovarian Neoplasms 3p were found statically significant. +other 32854743 hsa-mir-6131 Ovarian Neoplasms 3p were found statically significant. +other 32854743 hsa-mir-6131 Carcinoma, Ovarian Epithelial 3p were found statically significant. +other 32854743 hsa-mir-135b Carcinoma, Ovarian Epithelial 3p were found statically significant. +other 32854743 hsa-mir-4430 Carcinoma, Ovarian Epithelial 3p were found statically significant. +other 32854743 hsa-mir-135b Ovarian Neoplasms 3p were found statically significant. +lncRNA target 32854478 hsa-mir-146a Pre-Eclampsia Results: (1) The mRNA expression level of KCNQ1OT1 in the placenta of PE group was lower than that of control group (0.23+/-0.03 vs 0.51+/-0.04, P<0.05), and the miR-146a-3p expression level was higher than that of the control group (0.49+/-0.03 vs 0.31+/-0.03, P<0.05), there were statistical significant differences between the two groups. Conclusion: KCNQ1OT1 could target the regulation of miR-146a-3p through CXCL12/CXCR4 pathway in the proliferation, invasion an migration of HTR8/SVneo cells, which may be involved in the pathogenesis of PE. +transcription factor target 32854459 hsa-mir-4463 Follicle-stimulating hormone deficiency, isolated In particular, upregulation of miR-4463 expression by FSHR deficiency in human granulosa cells impaired 17beta-estradiol synthesis by targeting CYP19A1 and ESR1. +other 32854257 hsa-mir-141 Colorectal Neoplasms 3p upregulation signature previously described in advanced CRC did not discriminate the analyzed early-CRC cohort from six tumor-free donors (Tf-D). +other 32854257 hsa-mir-222 Colorectal Neoplasms 3p upregulation signature previously described in advanced CRC did not discriminate the analyzed early-CRC cohort from six tumor-free donors (Tf-D). +other 32854257 hsa-mir-221 Colorectal Neoplasms 3p upregulation signature previously described in advanced CRC did not discriminate the analyzed early-CRC cohort from six tumor-free donors (Tf-D). +genetics_GWAS 32853952 hsa-mir-27a Digestive System Neoplasms CONCLUSIONS: The miR-27a rs895819 polymorphism may be associated with an increased risk for digestive system cancers. +lncRNA target 32853944 hsa-mir-150 Colorectal Neoplasms Finally, the interactions and correlations among these ceRNA networks were validated by experiments on CRC cell lines and clinical tumor tissues, and a potential IGF2-AS/miR-150/IGF2 axis that perfectly conform to the ceRNA theory was determined. In general, the constructed novel IGF2-AS/miR-150/IGF2 network might provide potential mechanisms of CRC development, and could act as a promising target for CRC treatment. +lncRNA target 32853927 hsa-mir-10a Kidney Diseases CONCLUSION: The work elucidates that miR-10a-3p restoration decreases Th17/Treg ratio and attenuates renal injury in LN via inhibiting REG3A and the activation of JAK2/STAT3 pathway, which renews the therapeutic reference for LN management. +lncRNA target 32853927 hsa-mir-10a Lupus Nephritis CONCLUSION: The work elucidates that miR-10a-3p restoration decreases Th17/Treg ratio and attenuates renal injury in LN via inhibiting REG3A and the activation of JAK2/STAT3 pathway, which renews the therapeutic reference for LN management. +other 32853911 hsa-mir-186 high grade glioma Further research revealed that miR-186 could bind to the 3'-UTR (untranslated region) of c-Met, which acts as an oncogene in gliomas. +exosome 32853650 hsa-mir-26a Diabetic Nephropathies Therefore, we conclude that inhibiting exosome secretion by BSA-induced PTECs promotes miR-26a-5p expression in cells, thereby inhibiting the CHAC1/NF-kappaB pathways to prevent the inflammatory response in PTECs and delaying the development of DKD. +circulation_biomarker_diagnosis_ns 32853260 hsa-mir-449a Birth Weight Therefore, we conducted this study to clarify the involvement of pituitary miR-449a in the increase in blood pressure caused by higher glucocorticoids in LBW rats. +genetics_overexpression_suppress 32853022 hsa-mir-877 Stomach Neoplasms 5p overexpression can antagonize the promoting effect of SP on the development of gastric cancer, indicating that miR +transcription factor target 32853021 hsa-mir-22 Carcinoma, Ductal, Breast Although only miR-22 was shown potent to predict CR of BC patients, both miR-22 and miR-335 might act as tumor suppressor miRNAs in BC. +lncRNA target 32853020 hsa-mir-155 Liver Neoplasms In conclusion, our findings showed that miR5p could reverse ADR resistance in liver cancer by targeting ATG5, which may function as a potential target for liver cancer treatment. +genetics_overexpression_promote 32852921 hsa-mir-139 Spinal Cord Injuries 5p overexpression via administration with miR +other 32852903 hsa-mir-17 Lupus Erythematosus, Systemic CONCLUSION: This study is the first one to explore that the MIR17HG rs4284505 is associated with SLE risk; (A/G) genotype conferred a protective effect, while the (G/G) genotype showed increased susceptibility to SLE and association with the disease severity in the study population. +genetics_overexpression_promote 32852789 hsa-mir-7 Ataxia Neuropathy Spectrum Importantly, miR-7 deficiency significantly enhanced the production of related inflammatory cytokines including IL-1beta, IL-6 and IL-12, as well as TNF-alpha, on LPS-activated BMDMs, accompanied by elevated transduction of TLR4 signalling including Myd88-dependent and Myd88-independent pathways, whereas miR-7 overexpression significantly decreased the transduction of TLR4 signalling and the production of related inflammatory cytokines. +lncRNA target 32852789 hsa-mir-7 Disease Therefore, we provide the new evidence that miR-7 acts as a novel negative fine-tuner in regulating TLR4 signalling pathways by targeting FAM177A, which might throw light on the basal understanding on the regulatory mechanism of TLR4 signalling and benefit the development of therapeutic strategies against related clinical diseases. +circulation_biomarker_diagnosis_ns 32852767 hsa-mir-373 Neoplasms, Germ Cell and Embryonal Here, we describe an optimized research protocol to assess serum sample quality and quantify levels of a panel of four test miRNAs (miR-371a-3p, miR +circulation_biomarker_diagnosis_ns 32852767 hsa-mir-372 Neoplasms, Germ Cell and Embryonal Here, we describe an optimized research protocol to assess serum sample quality and quantify levels of a panel of four test miRNAs (miR-371a-3p, miR +circulation_biomarker_diagnosis_ns 32852767 hsa-mir-371a Neoplasms, Germ Cell and Embryonal Here, we describe an optimized research protocol to assess serum sample quality and quantify levels of a panel of four test miRNAs (miR-371a-3p, miR +circulation_biomarker_diagnosis_ns 32852767 hsa-mir-367 Neoplasms, Germ Cell and Embryonal Here, we describe an optimized research protocol to assess serum sample quality and quantify levels of a panel of four test miRNAs (miR-371a-3p, miR +lncRNA target 32852406 hsa-mir-145 Reperfusion Injury, Pulmonary Ischemia CONCLUSIONS: In summary, miR-145 enhances autophagy and aggravates lung I/R injury by promoting NF-kappaB transcriptional activity via SIRT1 expression. +genetics_overexpression_suppress 32852284 hsa-mir-7b Acute Lung Injury To further investigate the underlying mechanisms of NLRP3 in ALI, lncRNA MEG3 was silenced and miR-7b was overexpressed in LPS-induced NR8383 cell model of ALI, after which in vivo experiments were performed for further verification. +circulation_biomarker_diagnosis_ns 32851926 hsa-mir-186 Carcinoma, Non-Small-Cell Lung RESULTS: 1 in circle The relative expression level of miR-186 was greatly reduced in the serum and EBC of patients with non-small cell lung cancer, and the miR-186 expression level was reduced in different TNM stages of non-small cell lung cancer, from the early to later stages. +other 32851774 hsa-mir-195 Ovarian Neoplasms In conclusion, miR-195 controls MICU1 levels in ovarian cancer and could be exploited to normalize aberrant MICU1 expression, thus reversing both glycolysis and chemoresistance and consequently improving patient outcomes. +lncRNA target 32851074 hsa-mir-338 Osteosarcoma 3p/PTP1B axis might be a potential therapeutic target. +other 32851067 hsa-mir-205 Uterine Cervical Neoplasms 5p (r = -0.123, P = 0.044). +circulation_biomarker_diagnosis_ns 32851067 hsa-mir-16 Uterine Cervical Neoplasms In serum of patients with cervical cancer after CCRT+LWMH treatment, there was no significant correlation between VEGF-A and miR-15a-5p (r = -0.132, P = 0.209), miR +other 32851067 hsa-mir-195 Uterine Cervical Neoplasms 5p (r = -0.123, P = 0.044). +circulation_biomarker_diagnosis_ns 32851067 hsa-mir-15a Uterine Cervical Neoplasms In serum of patients with cervical cancer after CCRT+LWMH treatment, there was no significant correlation between VEGF-A and miR-15a-5p (r = -0.132, P = 0.209), miR +other 32851067 hsa-mir-205 Venous Thromboembolism 5p (r = -0.123, P = 0.044). +circulation_biomarker_diagnosis_ns 32851067 hsa-mir-15a Venous Thromboembolism In serum of patients with cervical cancer after CCRT+LWMH treatment, there was no significant correlation between VEGF-A and miR-15a-5p (r = -0.132, P = 0.209), miR +other 32851067 hsa-mir-195 Venous Thromboembolism 5p (r = -0.123, P = 0.044). +circulation_biomarker_diagnosis_ns 32851067 hsa-mir-29a Venous Thromboembolism In serum of patients with cervical cancer after CCRT+LWMH treatment, there was no significant correlation between VEGF-A and miR-15a-5p (r = -0.132, P = 0.209), miR +circulation_biomarker_diagnosis_ns 32851067 hsa-mir-16 Venous Thromboembolism In serum of patients with cervical cancer after CCRT+LWMH treatment, there was no significant correlation between VEGF-A and miR-15a-5p (r = -0.132, P = 0.209), miR +circulation_biomarker_diagnosis_ns 32851067 hsa-mir-29a Uterine Cervical Neoplasms In serum of patients with cervical cancer after CCRT+LWMH treatment, there was no significant correlation between VEGF-A and miR-15a-5p (r = -0.132, P = 0.209), miR +lncRNA target 32850952 hsa-mir-195a Intervertebral Disc Degeneration CONCLUSION: NEAT1 played its role in IVDD progression via partly by mediating the miR-195 expression and might be used as a potential target for IVDD therapy. +lncRNA target 32850952 hsa-mir-195 Intervertebral Disc Degeneration CONCLUSION: NEAT1 played its role in IVDD progression via partly by mediating the miR-195 expression and might be used as a potential target for IVDD therapy. +other 32850909 hsa-mir-214 Cardiovascular Diseases Accumulating evidence has demonstrated that miR-214 plays a pivotal role in the pathogenesis of cardiovascular diseases. +circulation_biomarker_diagnosis_ns 32850909 hsa-mir-214 Hyperuricemia Material and methods: We enrolled 30 patients with hyperuricemia and 32 healthy controls and analyzed the levels of miR-214 in the serum of the participants. Results: A significant reduction in circulating miR-214 in the hyperuricemia patients compared with the healthy controls, along with a negative correlation with UA levels was observed. +lncRNA target 32850853 hsa-mir-32 Spinal Cord Compression These findings suggest a role of the Xist/miR5p/Notch-1 axis in endogenous repair and provide a potential molecular target for the treatment of ischemia-related central nervous system (CNS) diseases. +other 32850813 hsa-mir-125b Colonic Neoplasms Besides, 3 pairs of important biomarkers associated with COAD metastasis were also identified: T cells follicular helper and hsa-miR-125b-5p (R = -0.200, P < 0.001), Macrophages M0 and hsa-miR-125b-5p (R = 0.170, P < 0.001) and Macrophages M0 and FAS (R = -0.370, P < 0.001). CONCLUSION: In this research, we found some significant ceRNAs (FAS and hsa-miR-125b-5p) and tumor-infiltrating immune cells (T cells follicular helper and Macrophages M0) might related to distance metastasis and prognosis of COAD. +genetics_GWAS 32850803 hsa-mir-374b Hemophilia A To understand this anomaly, we recently sequenced microRNAs (miRNAs) of two patients with mild and moderate HA with no F8 gene mutations and selected two highly expressing miRNAs, miR-374b-5p and miR-30c-5p, from the pool to explain the FVIII deficiency that could be mediated by miRNA-based F8/FVIII suppression. +genetics_GWAS 32850803 hsa-mir-186 Hemophilia A From this pool, two miRNAs, miR-19b-3p and miR5p, were found to be upregulated in a severe HA patient with a mutation in the F8 coding sequence and two HA patients without mutations in the F8 coding sequence were selected to demonstrate their role in F8 gene expression regulation in mammalian cells. +genetics_GWAS 32850803 hsa-mir-19b Hemophilia A From this pool, two miRNAs, miR-19b-3p and miR5p, were found to be upregulated in a severe HA patient with a mutation in the F8 coding sequence and two HA patients without mutations in the F8 coding sequence were selected to demonstrate their role in F8 gene expression regulation in mammalian cells. +other 32850781 hsa-mir-124 Neurogenic Inflammation Psychostimulants such as cocaine have been shown to activate microglia by downregulating miR-124, leading, in turn, to neuroinflammation. We thus rationalized that restoring the levels of miR-124 could function as a potential therapeutic approach for cocaine-mediated neuroinflammation. +other 32850751 hsa-mir-126 Pituitary Diseases MicroRNA-126 (miR-126) is an endothelial-specific microRNA that has shown beneficial effects on endothelial dysfunction. +lncRNA target 32850524 hsa-mir-141 Enterocolitis, Necrotizing 3p clearly alleviated inflammation response and oxidative stress damage in NEC, which was achieved through regulating inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) and oxidative stress markers (MPO, MDA, and SOD) expression. +genetics_overexpression_promote 32850439 hsa-mir-27b Triple Negative Breast Neoplasms MiR-27b-3p overexpression increased TNBC cell proliferation, migration, invasion, and metastasis. +other 32850377 hsa-mir-519a-2 Carcinoma, Hepatocellular 5p have similar effects on the promotion of HCC progression. +circRNA target 32850310 hsa-mir-493 Squamous Cell Carcinoma of Head and Neck In conclusion, our data suggested that circRNA_103862 promotes the proliferation of LSCC through targeting the miR5p/GOLM1 axis, and it might serve as a potential prognosis marker and therapy target for LSCC. +other 32850286 hsa-mir-221 Uterine Cervical Neoplasms longifolia leaf extract's vital contribution in regulating various protein expressions in HeLa cervical cancer cells to induce apoptotic cell death after downregulation miR5p. +lncRNA target 32850002 hsa-mir-93 Dementia, Vascular CONCLUSIONS: Taken together, these findings provide evidence that acupuncture attenuates cognitive impairment associated with inflammation through inhibition of the miRmediated TLR4/MyD88/NF-kappaB signaling pathway in experimental VD. +circulation_biomarker_diagnosis_ns 32849946 hsa-mir-93 Phenylketonurias We aimed to investigate whether peripheral blood expression of microRNA 93 (miR93) and microRNA 191 (miR191) in patients with MHT can predict the presence or absence of intracranial injury, reducing the unnecessary use of CCT. +circulation_biomarker_diagnosis_ns 32849946 hsa-mir-93 Brain Injuries We aimed to investigate whether peripheral blood expression of microRNA 93 (miR93) and microRNA 191 (miR191) in patients with MHT can predict the presence or absence of intracranial injury, reducing the unnecessary use of CCT. +circulation_biomarker_diagnosis_ns 32849946 hsa-mir-191 Phenylketonurias We aimed to investigate whether peripheral blood expression of microRNA 93 (miR93) and microRNA 191 (miR191) in patients with MHT can predict the presence or absence of intracranial injury, reducing the unnecessary use of CCT. Compared to MHT patients without TBI, mean serum miR191 levels were markedly elevated in patients with TBI. +circulation_biomarker_diagnosis_ns 32849946 hsa-mir-191 hypomelanosis of Ito Adding the measurement of serum miRNAs particularly miR191 to the clinical decision rules for a CCT scan in patients with MHI could allow a reduction in scans. +circulation_biomarker_diagnosis_ns 32849946 hsa-mir-191 Brain Injuries We aimed to investigate whether peripheral blood expression of microRNA 93 (miR93) and microRNA 191 (miR191) in patients with MHT can predict the presence or absence of intracranial injury, reducing the unnecessary use of CCT. Compared to MHT patients without TBI, mean serum miR191 levels were markedly elevated in patients with TBI. +genetics_overexpression_promote 32849915 hsa-mir-449b Glioma RESULTS: LINC00475 was identified to be overexpressed in hypoxic glioma samples, which was further observed to bind to and down-regulate miR-449b-5p, and negatively targeted AGAP2. CONCLUSION: Taken together, LINC00475 silencing exerted an inhibitory effect on glioma under hypoxic conditions by down-regulating AGAP2 via up-regulation of miR-449b-5p. +lncRNA target 32849824 hsa-let-7a Carcinoma, Non-Small-Cell Lung Our results showed that tanshinones suppressed NSCLC by upregulating the expressions of let-7a-5p via directly targeting AURKA. +other 32849791 hsa-mir-186 Breast Neoplasms The Long Non-coding RNA LINC01705 Regulates the Development of Breast Cancer by Sponging miR-186-5p to Mediate TPR Expression as a Competitive Endogenous RNA. +target gene 32849774 hsa-mir-153 Stomach Neoplasms Long Non-coding RNA FGD5-AS1 Regulates Cancer Cell Proliferation and Chemoresistance in Gastric Cancer Through miR-153-3p/CITED2 Axis. +circulation_biomarker_diagnosis_up 32849308 hsa-mir-1281 Diabetic Retinopathy Conclusion: Our findings suggest miR-1281 as a circulating biomarker of DR. +circulation_biomarker_diagnosis_ns 32848854 hsa-mir-27b Polycystic Ovary Syndrome Basal expression of circulating miRNA-27b (c-miR-27b), implicated in fatty acid metabolism, adipocyte differentiation and inflammation, was 1.8-fold higher in women with compared to without PCOS (P = 0.006) despite no difference in gluteal or abdominal AT miR-27b expression. We conclude that women with PCOS have a higher basal expression of c-miR-27b compared to women without PCOS and that 16 weeks of LV-HIT reduces the expression of this miRNA in women with PCOS. +other 32848773 hsa-mir-132 Neurodegenerative Diseases We propose that, nasal delivery of WGA-NPs-miR132 is an interesting novel therapeutic approach for the treatment of neurodegenerative diseases. +circulation_biomarker_diagnosis_up 32848764 hsa-mir-1297 Heart Failure 3p were significantly up-regulated, whereas the plasma miR-1297 was significantly decreased, and miR +circulation_biomarker_diagnosis_up 32848764 hsa-mir-4649 Heart Failure 3p were significantly up-regulated, whereas the plasma miR-1297 was significantly decreased, and miR +other 32848656 hsa-mir-411 Depression 5p-were significantly up-regulated in the DG of an unpredictable chronic mild stress (CMS) rat model of depression and reversed by antidepressant treatment. +other 32848656 hsa-mir-409 Depression 5p-were significantly up-regulated in the DG of an unpredictable chronic mild stress (CMS) rat model of depression and reversed by antidepressant treatment. +lncRNA target 32848473 hsa-mir-765 Glioma MiR-765 expression was negatively correlated with LINC00173 and NUTF2 in glioma tissues. CONCLUSION: Our research demonstrated that LINC00173 promotes glioma progression through targeting miR-765/NUTF2 axis. +lncRNA target 32848467 hsa-mir-26a Carcinoma, Non-Small-Cell Lung In this study, we aimed to reveal the influence of miR-26a-5p on the regulation of FAF1 expression and NSCLC progression, with the motivation of identifying a potential therapeutic target for NSCLC treatment. CONCLUSION: Taken together, we show that miR-26a-5p functions as an oncogenic microRNA in NSCLC by targeting FAF1 and may serve as a potential target for NSCLC treatment. +genetics_knock down_suppress 32848466 hsa-mir-149 Stomach Neoplasms CONCLUSION: Our studies disclosed that circNHSL1 knockdown repressed migration, invasion, and glutaminolysis in vitro and inhibited tumor growth in vivo by miR +genetics_overexpression_promote 32848465 hsa-mir-610 Colorectal Neoplasms Furthermore, we demonstrated circMAT2B upregulated expression levels of the miR-610 target gene E2F1, which is involved in cell proliferation, is overexpression in a broad range of human cancer including CRC. +lncRNA target 32848452 hsa-mir-103a Glioblastoma CONCLUSION: Silencing of FGD5-AS1 inhibited the viability, migration, and invasion of GBM cells by regulating the miR-103a-3p/TPD52 axis. +other 32848443 hsa-mir-100 Hirschsprung Disease In the stratified analysis, miR-100 rs1834306 GG genotype carriers had higher risk to develop HSCR in all clinical subtypes when compared with those with AA/AG genotypes, and OR was rising with HSCR aggravation (SHSCR: adjusted OR=1.28, 95% CI=1.03-1.59, P=0.029; LHSCR: adjusted OR=1.48, 95% CI=1.06-2.07, P=0.020; TCA: adjusted OR=2.12, 95% CI=1.22-3.69, P=0.008). +circulation_biomarker_diagnosis_ns 32848442 hsa-mir-186 Glomerulonephritis, Membranous The aim of this study was to study the levels of miR-30c and miR-186 in NS patients. Expression levels of the miR-30c and miR-186 were evaluated in plasma and peripheral blood mononuclear cell (PBMC) samples of adult patients with NS using real-time PCR. +genetics_knock down_promote 32848415 hsa-mir-874 Colorectal Neoplasms miR-874 knockdown and CDK8 overexpression significantly reversed the inhibitory effect of circ_0005576 knockdown on CRC cells malignant phenotype (P < 0.05 or P < 0.01). CONCLUSION: Circ_0005576 promoted malignant progression through the miR-874/CDK8 axis in CRC. +genetics_knock down_suppress 32848412 hsa-mir-15a Osteosarcoma LINC00662 Long Non-Coding RNA Knockdown Attenuates the Proliferation, Migration, and Invasion of Osteosarcoma Cells by Regulating the microRNA-15a-5p/Notch2 Axis. +genetics_knock down_promote 32848411 hsa-mir-29a Carcinoma, Hepatocellular Moreover, STAT3 knockdown suppressed the malignant behavior of HCC cells, and its anti-tumor function was reversed by treatment with miR-29a inhibitor. +genetics_knock down_promote 32848333 hsa-mir-24 Anorectal Malformations 3p inhibitor attenuated the effects of rno_circ_0005139 knockdown on ARM development. +genetics_overexpression_promote 32848140 hsa-mir-450b Diabetic Nephropathies Overexpression of Hoxaas3 promoted fibrogenesis, whereas Hoxaas3 inhibition attenuated lung fibrosis both in vitro and in vivo, through regulation of miR-450b-5p. In conclusion, our study showed the role and mechanism of the TGF-beta1/Smad4- Hoxaas3-miR-450b-5p-Runx1 axis for a better understanding of PF, demonstrated Hoxaas3 maybe a new diagnostic biomarker or potential therapeutic target for IPF. +other 32848034 hsa-mir-148a Neurogenic Inflammation Our mechanistic model explains how DENV uses the EV pathway to transfer miR-148a for modulating USP33 and downstream ATF3 levels in human microglial cells and contributes in neuroinflammation within the CNS. +circRNA target 32847606 hsa-mir-625 Endometrial Neoplasms 5p sponge, upregulating IGF1R and activating the PI3K/Akt pathway, suggesting the potential therapeutic use of hsa_circ_002577 in EC treatment. +circulation_biomarker_diagnosis_ns 32847388 hsa-mir-217 Cardiovascular Diseases Further analysis revealed that human plasma miR-217 is a biomarker of vascular aging and cardiovascular risk. CONCLUSIONS: Our results highlight the therapeutic potential of miR-217 inhibitors in aging-related cardiovascular disease. +circulation_biomarker_diagnosis_ns 32847388 hsa-mir-217 Atherosclerosis Further analysis revealed that human plasma miR-217 is a biomarker of vascular aging and cardiovascular risk. CONCLUSIONS: Our results highlight the therapeutic potential of miR-217 inhibitors in aging-related cardiovascular disease. +circulation_biomarker_diagnosis_up 32846929 hsa-mir-1 Diabetes Mellitus In the control diet group, validated were down-regulated plasma hsa-miR +other 32846929 hsa-mir-122a Diabetes Mellitus Among five down-regulated salivary miRs, hsa-miR3p and hsa-miR-122a-5p were validated, which are associated with diabetes mellitus, acute coronary syndrome and non-alcoholic fatty liver disease. +circulation_biomarker_diagnosis_up 32846929 hsa-mir-25 Diabetes Mellitus In the control diet group, validated were down-regulated plasma hsa-miR +other 32846929 hsa-mir-92 Diabetes Mellitus Among five down-regulated salivary miRs, hsa-miR3p and hsa-miR-122a-5p were validated, which are associated with diabetes mellitus, acute coronary syndrome and non-alcoholic fatty liver disease. +tissue_expression_down 32846757 hsa-mir-335 Carcinoma, Non-Small-Cell Lung The log-rank test indicated that patients with decreased miR-335 expression experienced poor overall survival in NSCLC (P = .029).The results of the present study indicated that miR-335 was down-expressed in NSCLC, and is associated with tumor progression and poor prognosis, suggesting that the expression of miR-335 might be an independent prognostic factor of overall survival in patients with NSCLC. +other 32846274 hsa-mir-140 Alzheimer Disease 3p) were top-ranked predictors of multiple cognitive outcomes (Fluid, Crystallized, and Overall Cognition) and past studies of these miRNA link them to cellular senescence, inflammatory signals for atherosclerotic formation, and potential development of neurodegenerative disorders (e.g., Alzheimer's disease). +other 32846274 hsa-mir-140 Nerve Degeneration 3p) were top-ranked predictors of multiple cognitive outcomes (Fluid, Crystallized, and Overall Cognition) and past studies of these miRNA link them to cellular senescence, inflammatory signals for atherosclerotic formation, and potential development of neurodegenerative disorders (e.g., Alzheimer's disease). +other 32846274 hsa-mir-197 Neurodegenerative Diseases 3p) were top-ranked predictors of multiple cognitive outcomes (Fluid, Crystallized, and Overall Cognition) and past studies of these miRNA link them to cellular senescence, inflammatory signals for atherosclerotic formation, and potential development of neurodegenerative disorders (e.g., Alzheimer's disease). +other 32846274 hsa-mir-140 Neurodegenerative Diseases 3p) were top-ranked predictors of multiple cognitive outcomes (Fluid, Crystallized, and Overall Cognition) and past studies of these miRNA link them to cellular senescence, inflammatory signals for atherosclerotic formation, and potential development of neurodegenerative disorders (e.g., Alzheimer's disease). +other 32846274 hsa-mir-197 Alzheimer Disease 3p) were top-ranked predictors of multiple cognitive outcomes (Fluid, Crystallized, and Overall Cognition) and past studies of these miRNA link them to cellular senescence, inflammatory signals for atherosclerotic formation, and potential development of neurodegenerative disorders (e.g., Alzheimer's disease). +other 32846274 hsa-mir-197 Nerve Degeneration 3p) were top-ranked predictors of multiple cognitive outcomes (Fluid, Crystallized, and Overall Cognition) and past studies of these miRNA link them to cellular senescence, inflammatory signals for atherosclerotic formation, and potential development of neurodegenerative disorders (e.g., Alzheimer's disease). +circRNA target 32846020 hsa-mir-21 Acute Lung Injury CircC3P1 attenuated pro-inflammatory cytokine production and cell apoptosis in ALI induced by sepsis through modulating miR-21, indicating that circC3P1 is a promising therapeutic biomarker for sepsis-induced ALI. +circRNA target 32846020 hsa-mir-21 Sepsis CircC3P1 attenuated pro-inflammatory cytokine production and cell apoptosis in ALI induced by sepsis through modulating miR-21, indicating that circC3P1 is a promising therapeutic biomarker for sepsis-induced ALI. +circulation_biomarker_prognosis_ns 32845540 hsa-mir-146b Respiratory Distress Syndrome Subsequent multivariate logistic regression showed that miR-146b, age, smoke, respiratory infection, and serum creatinine predicted ARDS risk independently, and their combination well-discriminated ARDS sepsis patients from non-ARDS sepsis patients (AUC: 0.863, 95% CI: 0.792-0.934). +circulation_biomarker_prognosis_ns 32845540 hsa-mir-146b Sepsis Subsequent multivariate logistic regression showed that miR-146b, age, smoke, respiratory infection, and serum creatinine predicted ARDS risk independently, and their combination well-discriminated ARDS sepsis patients from non-ARDS sepsis patients (AUC: 0.863, 95% CI: 0.792-0.934). +lncRNA target 32845082 hsa-mir-29b Cardiovascular Diseases Inhibition of miR-29b in CAVD rats prevented from vascular and valvular calcification and induced TGF-beta3 expression, suggesting that the miR-29b/TGF-beta3 axis may play a regulatory role in the pathogenesis of vascular and valvular calcification and could play a significant role in the treatment of CAVD and other cardiovascular diseases. +lncRNA target 32845082 hsa-mir-29b autosomal recessive congenital bilateral absence of vas deferens Inhibition of miR-29b in CAVD rats prevented from vascular and valvular calcification and induced TGF-beta3 expression, suggesting that the miR-29b/TGF-beta3 axis may play a regulatory role in the pathogenesis of vascular and valvular calcification and could play a significant role in the treatment of CAVD and other cardiovascular diseases. +other 32845082 hsa-mir-29b Aortic Valve Disease We aimed to investigate the role of the miR-29b and its effect on TGF-beta3 pathway in vascular and valvular calcification in a rat model of calcific aortic valve diseases (CAVD). +lncRNA target 32844999 hsa-mir-125a Blood Platelet Disorders miR-125a-5p and L-plastin may be relevant targets for increasing in vitro platelet manufacturing and for managing quantitative platelet disorders. +lncRNA target 32844995 hsa-mir-140 Coronary Artery Disease Our results revealed that lncRNA NEAT1 increased cell viability and inhibited CAD cell apoptosis possibly by activating the miR +circulation_biomarker_prognosis_down 32844953 hsa-mir-144 Retinoblastoma CONCLUSIONS: miR-144 expression was downregulated in serum and tissue samples of RB patients and may function as a diagnostic and prognostic marker for RB. +circulation_biomarker_diagnosis_ns 32844595 hsa-mir-939 Cardiomegaly These suggest that CHF patients exhibited elevated serum miR +exosome 32844579 hsa-mir-802 Heart Diseases CONCLUSIONS: Hypertrophic adipocyte-derived exosomal miR5p caused cardiac insulin resistance through downregulating HSP60. +genetics_overexpression_promote 32844573 hsa-mir-522 Carcinoma, Non-Small-Cell Lung 3p overexpression abolished the inhibitory effect of SOCS5 on cell viability, migration and invasion in NSCLC. +lncRNA target 32844486 hsa-mir-519e Uterine Cervical Neoplasms Therefore, GABPB1-AS1 functioned as a tumor activator in CC pathogenesis by binding to miR-519e-5p and destroying its tumor suppressive function. +other 32844284 hsa-mir-199a Urinary Bladder Neoplasms Collectively, our findings highlight an axis of LUCAT1/miR-199a/b-5p in MIBC pathogenesis. +lncRNA target 32843721 hsa-mir-16 Carcinoma, Endometrioid Computational integration of miRNA with mRNA targets revealed deregulated let-7 and miR-16 target genes, similar to published human DICER1-mutant endometrial cancers from TCGA (The Cancer Genome Atlas). +lncRNA target 32843721 hsa-let-7 Carcinoma, Endometrioid Computational integration of miRNA with mRNA targets revealed deregulated let-7 and miR-16 target genes, similar to published human DICER1-mutant endometrial cancers from TCGA (The Cancer Genome Atlas). +epigenetics 32843060 hsa-mir-218 Osteosarcoma CONCLUSIONS: SNHG10 increases the methylation of miR-218 gene to promote glucose uptake and cell proliferation in OS. +lncRNA target 32842846 hsa-mir-125b Carcinoma, Ovarian Epithelial Our results supported that miR-125b contributes to the progression of EOC by targeting S100A4. +other 32842822 hsa-mir-155 Prosthesis Failure 5p) were significantly validated in endometrial samples. +other 32842822 hsa-mir-455 Prosthesis Failure 5p) were significantly validated in endometrial samples. +other 32842822 hsa-mir-4423 Prosthesis Failure 5p) were significantly validated in endometrial samples. +other 32842533 hsa-mir-195 Carcinoma, Endometrioid 5p expression was significantly downregulated in SEC. +other 32842533 hsa-mir-497 Carcinoma, Endometrioid 5p expression was significantly downregulated in SEC. +other 32842533 hsa-mir-34a Carcinoma, Endometrioid 5p expression was significantly downregulated in SEC. +other 32842533 hsa-let-7g Carcinoma, Endometrioid 5p expression was significantly downregulated in SEC. +transcription factor target 32842444 hsa-mir-148b Glioma Objective: To investigate the effect of miR-148b-3p on invasion and migration of glioma cells and the possible molecular mechanism. Conclusion: miR-148b-3p can inhibit the invasion and migration of human glioma U251 cells by inhibiting the activation of Wnt signaling pathway. +lncRNA target 32842443 hsa-mir-451 Multiple Myeloma [miR-451 inhibits malignant progression of multiple myeloma RPMI-8226 cells by targeting c-Myc]. Objective: To investigate the effects of microRNA-451 on proliferation, invasion and migration of multiple myeloma RPMI-8226 cells and its mechanism. +lncRNA target 32842442 hsa-mir-141 Stomach Neoplasms 3p can inhibit the proliferation and migration of human gastric cancer BGC-823 cells, which may be related to the inhibition of NF-kappaB signaling pathway activation. +genetics_knock down_suppress 32842350 hsa-mir-197 Squamous Cell Carcinoma of Head and Neck Conclusions: Knockdown of hsa_circ_0008898 inhibited OSCC cells proliferation, cloning, migration and invasion and induced cell cycle arrest in vitro by regulating the miR +other 32841775 hsa-mir-34a Uterine Cervical Neoplasms Notably, low expression of miR-34a was markedly associated with the poor overall survival of cervical cancer patients as revealed by Kaplan-Meier survival analysis. +genetics_knock down_promote 32841663 hsa-mir-125b Carcinoma, Squamous Cell, Cutaneous SIGNIFICANCE: PICSAR knockdown suppressed cell proliferation and invasion and promoted apoptosis in CSCC cells by regulating miR-125b/YAP1 axis, providing new sights for treatment of CSCC. +lncRNA target 32841649 hsa-mir-223 Cataract, Age-Related In summary, MEG3 promoted ARC progression by up-regulating TP53INP1 expression through suppressing miR-223 and promoting P53 expression, which would provide a novel insight into the pathogenesis of ARC. +exosome 32841514 hsa-mir-216a Lung Neoplasms (2020), Long non-coding RNA TP73-AS1 facilitates progression and radioresistance in lung cancer cells by the miR-216a-5p/CUL4B axis with exosome involvement. +genetics_knock down_promote 32841458 hsa-mir-342 Osteosarcoma Additionally, LINC00210 knockdown improved the radiosensitivity of osteosarcoma cells by regulating GFRA1 expression via sponging miR +circulation_biomarker_diagnosis_ns 32841353 hsa-mir-4454 Obesity CONCLUSIONS Obesity was associated to an alteration of the plasmatic miRNA landscape, wherein miR-4454 levels were higher, associated with insulin-resistance and modulated by obesity-controlling interventions. +genetics_knock down_suppress 32841217 hsa-mir-34a Pulmonary Fibrosis Our data indicate that dysregulation of glucose metabolism in fLfs is causally linked to loss of basal expression of p53 and miR-34a. +lncRNA target 32841053 hsa-mir-590 Carcinoma, Non-Small-Cell Lung Furthermore, we confirmed that lncRNA ZFAS1 inhibited cell division cycle 42 (Cdc42) expression by regulating of miR +lncRNA target 32840296 hsa-mir-940 Breast Neoplasms Our study suggested that miR-940 could be a novel molecular target for therapies against BC. +genetics_overexpression_suppress 32840181 hsa-mir-155 Angelman Syndrome In summary, our study demonstrates that MALAT1 overexpression attenuates AS by inhibiting ox-LDL-stimulated DCs maturation via miR +lncRNA target 32840137 hsa-mir-146b Anemia, Aplastic Overall, our results found that miR-146b-5p was highly expressed in BMSCs from children with AA, and our further studies indicated that miR-146b-5p improved AA via promoting SIAH2-mediated ubiquitination of PPARgamma protein. +lncRNA target 32840094 hsa-mir-1290 Leukemia, Myeloid, Acute "We, the Editors and Publisher of Journal of Biological Regulators and Homeostatic Agents, have retracted the following article: ""miR-1290 promotes proliferation and suppresses apoptosis in acute myeloid leukemia by targeting FOXG1/SOCS3""." +genetics_knock down_promote 32839935 hsa-mir-516b Melanoma The rescue experiments revealed that both miR-516b inhibitor and GRM3 overexpression could reverse the inhibition effect of circ_0079593 knockdown on melanoma progression. +transcription factor target 32839459 hsa-mir-218 Neuroblastoma In human neuroblastoma cells, transfection with miR-133a and miR-218 reduced both endogenous SV2A mRNA and protein levels, confirming miRNA targeting of the SV2A gene. +transcription factor target 32839459 hsa-mir-133a Neuroblastoma In human neuroblastoma cells, transfection with miR-133a and miR-218 reduced both endogenous SV2A mRNA and protein levels, confirming miRNA targeting of the SV2A gene. +lncRNA target 32838835 hsa-mir-520f Glioblastoma Therefore, targeting the WEE2-AS1miR-520f-3pSP1 pathway might be a promising therapy for the management of GBM in the future. +genetics_overexpression_promote 32838785 hsa-mir-425 Lung Neoplasms 5p is overexpressed in LCa tissue and enhances the proliferative and colony formation capacity of the LCa cell lines A549 and NCI-H1299. +other 32838607 hsa-mir-1225 Colorectal Neoplasms Here, we show that miR5p prevents migration and invasion of colorectal cancer cells. +genetics_GWAS 32838589 hsa-mir-196a-2 Vitiligo CONCLUSION: MiRNA 196a-2 C/T (11614913) gene polymorphism and the elevated serum tyrosinase levels might be related to the pathogenesis of vitiligo and may affect its therapeutic response. +genetics_GWAS 32838437 hsa-mir-23b Acromegaly SNPs of miR-23b, miR-107 and HMGA2 and their Relations with the Response to Medical Treatment in Acromegaly Patients. +genetics_GWAS 32838437 hsa-mir-107 Acromegaly SNPs of miR-23b, miR-107 and HMGA2 and their Relations with the Response to Medical Treatment in Acromegaly Patients. +lncRNA target 32835852 hsa-mir-210 Sjogren's Syndrome In our previous work, the expression of miR-210 was considerably induced in diseased Apostichopus japonicus with skin ulcer syndrome (SUS). To further explore the mechanism of miR-210 in regulating the SUS, this study identified E2F transcription factor 3 (E2F3), a candidate target of miR-210, from the sea cucumber A. +other 32835852 hsa-mir-210 Skin Ulcer In our previous work, the expression of miR-210 was considerably induced in diseased Apostichopus japonicus with skin ulcer syndrome (SUS). +lncRNA target 32835591 hsa-mir-204 Uterine Cervical Neoplasms In addition, we found that lncRNA UCA1 could sponge miR-204 and promote the proliferation and invasion of cervical cancer cells via the up-regulating of KIF20A expression. As a result, the inhibiting of UCA1 could lower cervical cancer (CC) cells growth rate in vivo.Our results identified that UCA1 could serve as an oncogene in cervical cancer cell progression through the modulating of miR-204/KIF20A axis. +exosome 32835529 hsa-mir-551b Diabetes Mellitus RESULTS: MiRNA sequencing revealed that 295 miRNAs were upregulated and 138 miRNAs were downregulated in exosomes of the diabetes and cataracts group (DMC) compared with the age-related cataracts group (ARC), among which miR-551b was highly expressed with a log2 fold change of 5.99. +exosome 32835529 hsa-mir-551b Cataract RESULTS: MiRNA sequencing revealed that 295 miRNAs were upregulated and 138 miRNAs were downregulated in exosomes of the diabetes and cataracts group (DMC) compared with the age-related cataracts group (ARC), among which miR-551b was highly expressed with a log2 fold change of 5.99. +other 32835083 hsa-mir-1307 COVID-19 According to the result, clinical assessment of these three herbal compounds and hsa-miR3p may have significant outcomes for the prevention, control, and treatment of COVID-19 infection. +transcription factor target 32833902 hsa-mir-455 Reperfusion Injury, Cerebral Ischemia 5p improved cerebral I/R injury by targeting FLT3, which suggests a potential new target for the prevention of cerebral I/R injury. +genetics_knock down_promote 32833901 hsa-mir-761 Myocardial Infarction Our current work suggested that the knockdown of ZFAS1 protected against H/R-induced injury in HL-1 cells at least partly through the regulation of miR-761/CDIP1 axis, illuminating a novel therapeutic avenue for AMI management. +lncRNA target 32833900 hsa-mir-532 Myocardial Reperfusion Injury CONCLUSION: TUG1 silence ameliorated H/R-induced cardiomyocytes injury through regulating miR5p/Sox8 axis, suggesting a potential therapeutic target for preventing myocardial ischemia/reperfusion injury. +genetics_knock down_promote 32833899 hsa-mir-26a Atherosclerosis In conclusion, OIP5-AS1 knockdown promoted cell proliferation and suppressed apoptosis and inflammatory response in ox-LDL-treated HUVECs by targeting miR-26a-5p through blocking the AKT/NF-kappaB pathway, indicating a promising strategy for AS treatment. +other 32833553 hsa-mir-146b Fibrosis In fibrotic liver tissues, miR-146b expression was positively correlated with p65 mRNA, but HNF1A mRNA was inversely correlated with p65, and miR-146b expression. +genetics_knock down_promote 32833504 hsa-mir-138 Breast Neoplasms 5p directly interacted with NEAT1 and its knockdown reversed the suppressive impact of NEAT1 downregulation on the progression of BC cells. +circRNA target 32833503 hsa-mir-379 Carcinoma, Non-Small-Cell Lung 5p/TRIM65 axis, suggesting that circ_0011292 was a promising therapeutic target for NSCLC chemotherapy. +genetics_knock down_promote 32833501 hsa-mir-524 Glioma Conclusions: Knockdown of circHIPK3 promoted TMZ sensitivity in glioma by modulating proliferation, metastasis, and apoptosis through miR +genetics_overexpression_promote 32833340 hsa-mir-3175 Prostatic Neoplasms Inhibitor or mimics transfections were used to overexpress or silence miR-3175 in prostate cancer cells. +exosome 32833280 hsa-mir-124 Diabetes Mellitus These findings indicate that osteocyte-derived exosomes carrying miR3p may regulate Gal-3 expression of osteoblasts, especially under high-glucose conditions, suggesting a possible mechanism for DM-related alveolar bone pathologies. +exosome 32833280 hsa-mir-124 Periodontitis These findings indicate that osteocyte-derived exosomes carrying miR3p may regulate Gal-3 expression of osteoblasts, especially under high-glucose conditions, suggesting a possible mechanism for DM-related alveolar bone pathologies. +genetics_overexpression_suppress 32833189 hsa-mir-506 Endometriosis Overexpression of miR +other 32832554 hsa-mir-26b Meningioma 5p, which are involved in the transcription factor-miRNA-mRNA coregulation network, were found to be associated with meningioma. +other 32832554 hsa-mir-574 Meningioma 5p, which are involved in the transcription factor-miRNA-mRNA coregulation network, were found to be associated with meningioma. +other 32832554 hsa-mir-98 Meningioma 5p, which are involved in the transcription factor-miRNA-mRNA coregulation network, were found to be associated with meningioma. +other 32832554 hsa-mir-335 Meningioma 5p, which are involved in the transcription factor-miRNA-mRNA coregulation network, were found to be associated with meningioma. +target gene 32832335 hsa-mir-197 Ovarian Neoplasms miR-197-3p reduces epithelial-mesenchymal transition by targeting ABCA7 in ovarian cancer cells. +lncRNA target 32831924 hsa-mir-326 Carcinoma, Non-Small-Cell Lung In conclusion, RPPH1 promoted NSCLC progression and lung cancer cell resistance to CDDP through miR-326 and WNT2B. +circulation_biomarker_diagnosis_up 32831917 hsa-mir-141 Colonic Neoplasms The ROC curve for the diagnosis of colon cancer was further plotted in combination with serum miR-34c and miR-141. +circulation_biomarker_diagnosis_up 32831917 hsa-mir-34c Colonic Neoplasms The ROC curve for the diagnosis of colon cancer was further plotted in combination with serum miR-34c and miR-141. +transcription factor target 32831915 hsa-mir-149 Carcinoma, Non-Small-Cell Lung 1-3p and miR-149 can be used as new molecular targets for the diagnosis and treatment of NSCLC. +transcription factor target 32831915 hsa-mir-218-1 Carcinoma, Non-Small-Cell Lung 1-3p and miR-149 can be used as new molecular targets for the diagnosis and treatment of NSCLC. +target gene 32831914 hsa-mir-490 Carcinoma, Hepatocellular MicroRNA-490-3p suppresses the proliferation and invasion of hepatocellular carcinoma cells via targeting TMOD3. +genetics_overexpression_promote 32831912 hsa-mir-130a Plasmablastic Lymphoma Overexpression of microRNA-130a predicts adverse prognosis of primary gastrointestinal diffuse large B-cell lymphoma. +circulation_biomarker_diagnosis_ns 32831874 hsa-mir-135 Depression The study suggests that FAE intervention controls anxiety and depression outcomes and improves life quality in CHD patients by affecting serum levels of miR-124 and miR-135. +circulation_biomarker_diagnosis_ns 32831874 hsa-mir-124 Depression The study suggests that FAE intervention controls anxiety and depression outcomes and improves life quality in CHD patients by affecting serum levels of miR-124 and miR-135. +circulation_biomarker_diagnosis_ns 32831874 hsa-mir-124 Anxiety Disorders The study suggests that FAE intervention controls anxiety and depression outcomes and improves life quality in CHD patients by affecting serum levels of miR-124 and miR-135. +circulation_biomarker_diagnosis_ns 32831874 hsa-mir-135 Anxiety Disorders The study suggests that FAE intervention controls anxiety and depression outcomes and improves life quality in CHD patients by affecting serum levels of miR-124 and miR-135. +circulation_biomarker_diagnosis_up 32831826 hsa-mir-181b Pancreatic Carcinoma CONCLUSION: The combination of plasma miR-181b, miR-196a, and miR-210 had a good diagnostic value for PC. +circulation_biomarker_diagnosis_up 32831826 hsa-mir-210 Pancreatic Carcinoma CONCLUSION: The combination of plasma miR-181b, miR-196a, and miR-210 had a good diagnostic value for PC. +circulation_biomarker_diagnosis_up 32831826 hsa-mir-196a Pancreatic Carcinoma CONCLUSION: The combination of plasma miR-181b, miR-196a, and miR-210 had a good diagnostic value for PC. +genetics_overexpression_promote 32831653 hsa-mir-578 Breast Neoplasms CircZFR silencing or miR-578 overexpression repressed BC cell viability, colony formation, migration, invasion, and glycolysis and enhanced cell apoptosis in vitro. +target gene 32831649 hsa-mir-1179 Uterine Cervical Neoplasms FOXA1-induced circOSBPL10 potentiates cervical cancer cell proliferation and migration through miR-1179/UBE2Q1 axis. +genetics_knock down_promote 32831647 hsa-mir-590 Carcinoma, Non-Small-Cell Lung 5p, and THBS2 overexpression reversed the effects of circ_0020123 knockdown on cell proliferation, migration and apoptosis in NSCLC cells. +circRNA target 32830578 hsa-mir-431 Melanoma Our findings demonstrated that circ 0001591 inhibits the progression of human melanoma through ROCK1/PI3K/AKT signal pathway by targeting ROCK1 by miR +lncRNA target 32830547 hsa-mir-128 Inflammation Moreover, the PI3K allosteric activator 740 Y-P abolished the inhibition of miR3p in apoptosis, degradation of chondrocyte matrix, and inflammation. +lncRNA target 32830547 hsa-mir-128 Osteoarthritis 3p targets WISP1 to regulate chondrocyte proliferation, apoptosis, degradation of chondrocyte matrix, and production of proinflammatory cytokines via the PI3K/Akt/NF-kappaB pathway, which plays a suppressed role in OA. +circRNA target 32830397 hsa-mir-516b Osteoporosis CONCLUSIONS: Circ-SLC8A1 blocks the inhibitory effect of miR-516b-5p on the downstream target gene AKAP2 and promotes osteoporosis. +lncRNA target 32830348 hsa-mir-20a Diabetic Retinopathy To explore the functional significance between microRNA-320a (miR-320a) and AQP4 in pathological hypoxia-induced DR related retinal edema, we hypothesized that miR-320a regulates AQP4 expression and internalization to relieve the edema of Muller cells under the pathological retinal hypoxia stress by targeting AQP4, thereby attenuate the damage of Muller cells. +other 32830258 hsa-mir-146a Glomerulonephritis, IGA NGAL mRNA and miR-146a were upregulated in the biopsies of patients with progressive IgAN compared with non-progressive IgAN. +other 32830258 hsa-mir-146a Nephritis, Interstitial NGAL mRNA and miR-146a were upregulated in the biopsies of patients with progressive IgAN compared with non-progressive IgAN. +other 32830258 hsa-mir-146a Diabetic Nephropathies NGAL mRNA and miR-146a were upregulated in the biopsies of patients with progressive IgAN compared with non-progressive IgAN. +other 32830146 hsa-mir-146a Diabetes Mellitus Beside slight improvement of hyperglycemia, troxerutin prevented the activation of NF-B-dependent inflammatory signaling in the aorta of diabetic rats, and this response may be regulated by microRNA-146a. +genetics_knock down_promote 32830093 hsa-mir-337 Stomach Neoplasms The proliferation, invasion and migration of GC cells were simultaneously inhibited by XIST knockdown, and the relationship between XIST and miR-337 was confirmed by bioinformatics analysis. +transcription factor target 32829178 hsa-mir-378 Bone Diseases In conclusion, miR-378 suppressed osteogenesis and bone formation via inactivating Wnt/beta-catenin signaling, suggesting that miR-378 may be a potential therapeutic target for bone diseases. +other 32828867 hsa-mir-451a Breast Neoplasms Cumulatively, research on miR-451a may be valuable for BC treatment. +circulation_biomarker_diagnosis_ns 32828851 hsa-mir-223 Pediatric Obesity In silico-analysis disclosed several specific circulating CNP-linked miRNAs among which miR-33a-3p, miR +circulation_biomarker_diagnosis_ns 32828851 hsa-mir-142 Pediatric Obesity In silico-analysis disclosed several specific circulating CNP-linked miRNAs among which miR-33a-3p, miR +circulation_biomarker_diagnosis_ns 32828851 hsa-mir-33a Pediatric Obesity In silico-analysis disclosed several specific circulating CNP-linked miRNAs among which miR-33a-3p, miR +genetics_knock down_promote 32828314 hsa-mir-523 Retinoblastoma Further gain- and loss-function experiments verified that both upregulation of Linc-PINT and miR +genetics_knock down_promote 32828310 hsa-mir-1248 Carcinoma, Non-Small-Cell Lung The upregulation of TRIM24 partially reversed circEPSTI1 knockdown- or miR-1248 overexpression-induced tumor suppressive effect in NSCLC cells. +other 32828305 hsa-mir-128-1 Myocardial Reperfusion Injury 1-5p regulates Gadd45g-mediated cardiomyocyte apoptosis in myocardial I/R injury. +lncRNA target 32828296 hsa-mir-135b Carcinoma, Hepatocellular Our study not only deepens the insight into the Hippo pathway homeostasis, but also suggests miR-135b as a potential prognosis biomarker and therapeutic target for HCC. +circulation_biomarker_diagnosis_ns 32828284 hsa-mir-378a Lung Injury Compared with untreated MSCs, MSCs transfected with miRNA-378a-5p exhibited more significant decreases in lung injury score, white blood cell count and protein content while restoring respiratory indexes. In conclusion, MSCs transfected with miRNA-378a-5p were more effective in treating phosgene-induced lung injury by repairing the secretion of alveolar epithelial cells and improving the permeability of vascular endothelial cells compared with MSCs alone. +transcription factor target 32827803 hsa-mir-150 Carcinoma, Non-Small-Cell Lung 5p may promote lung cancer by inhibiting the suppressor gene LKB1 in NSCLC. +lncRNA target 32827683 hsa-mir-22 Neuralgia Collectively, our study revealed that circZNF609 promoted inflammation factors expression to aggravate neuropathic pain progression via miR +lncRNA target 32827680 hsa-mir-503 Osteosarcoma In conclusion, we indicated circ_0010220 can be an important biomarker for osteosarcoma via regulating miR +other 32826973 hsa-mir-155 Obesity RESULTS The obese group had higher LEP (p<0.001) and PPAR (p=0.016) expression and lower ADIPOQ expression (p=0.017), and also had higher expression of miR-210 (p=0.039), whereas lower expression of miR-155 (p=0.019) and miR-27a (p=0.028) as compared to lean controls. CONCLUSIONS Individuals with previous infection by Ad-36 had higher expression of the pro-adipogenic miR-17 and lower expression of the anti-adipogenic miR-155, which could lead to an increased adipogenic status by positively modulating PPAR expression in adipose tissue from obese subjects. +other 32826878 hsa-mir-1231 Spinal Cord Injuries This lncRNA functioned as a ceRNA for miR5p/Col1a1 axis and enhanced microglial pyroptosis after SCI by activating the PI3K/AKT pathway. +lncRNA target 32826876 hsa-mir-942 Squamous Cell Carcinoma of Head and Neck 5p/LTBP2 axis affects OSCC cell proliferation and invasion via the acceleration of EMT and the phosphorylation of PI3K/Akt/mTOR signaling pathway components. +lncRNA target 32826866 hsa-mir-489 Glioma 3p/HIGD1A axis in glioma, suggesting that targeting LEF1-AS1 might be a promising method for glioma therapy in the future. +lncRNA target 32826856 hsa-mir-26a Carcinoma, Pancreatic Ductal Functionally, elevated expression of miR-26a-5p was found to inhibit the proliferation, migration, and invasion of PDAC cells in vitro, while ARNTL2 increased expression could partially abolish the suppressive effect of miR-26a-5p. +circulation_biomarker_diagnosis_up 32826854 hsa-mir-873 Myocardial Infarction 5p/XIAP axis and circulating exosomal lncRNA-UCA1 may be a promising novel biomarker for the diagnosis of AMI. +lncRNA target 32826852 hsa-mir-20b Hypoxia Of these, miR-20b was found to be the most important miRNA which targeted on the key autophagy kinase ULK1 and inhibited hypoxia/re-oxygenation injury-induced autophagy by decreasing both autophagosomes and LC3I to II transition rate and P62 degradation. +genetics_knock down_promote 32826710 hsa-mir-338 Colorectal Neoplasms As expected, XIST knockdown inhibited colorectal cancer cell growth by modulating miR +transcription factor target 32826638 hsa-mir-344 Cardiomyopathies Exercise-mediated cardioprotection by upregulating miR-344g-5p, which targets Hmgcs2 mRNA, prohibits HMGCS2 upregulation and thus lipotoxicity. +lncRNA target 32826607 hsa-mir-34c Spinal Cord Injuries CONCLUSION The study provided evidence that miR-34c could promote neuronal recovery in rats with SCI through inhibiting CXCL14 expression and inactivating the JAK2/STAT3 pathway. +genetics_overexpression_promote 32826455 hsa-mir-145 Uveal melanoma In addition, the numbers of invaded MUM-2B and OCM-1 cells with miR-145 overexpression were significantly lower than the controls (35.7 /- 3.3 vs. 279.1 /- 4.9, t = 273.75, P < 0.001 and 69.5 /- 4.4 vs. 95.6 /- 4.7, t = 21.27, P < 0.001, respectively). +other 32826416 hsa-mir-145 Osteosarcoma Significantly upregulated lncRNA ZEB2-AS1 expression in osteosarcoma patients influences the prognosis of patients, and ZEB2-AS1 accelerates tumorigenesis and osteosarcoma development by downregulating miR-145. +genetics_overexpression_promote 32826415 hsa-mir-199a Esophageal Squamous Cell Carcinoma Finally, we demonstrated that overexpression of miR-199a-3p enhanced proliferation-inhibiting effects of MK2206, an inhibitor of Akt, to ESCC cells, which might be related that MK2206 eliminated the activation of miR-199a-3p to p-Akt. +lncRNA target 32826250 hsa-mir-200c Triple Negative Breast Neoplasms CONCLUSION: miR-200c attenuates TNBC cell invasion and EMT by targeting ZEB2. +circulation_biomarker_diagnosis_down 32826242 hsa-mir-146a Inflammatory Bowel Diseases CONCLUSIONS: miRNA-146a was down-regulated in UC patients and was negatively correlated with serum levels of inflammatory factors as well as severity of UC patients. +circulation_biomarker_diagnosis_down 32826242 hsa-mir-146 Inflammatory Bowel Diseases CONCLUSIONS: miRNA-146a was down-regulated in UC patients and was negatively correlated with serum levels of inflammatory factors as well as severity of UC patients. +transcription factor target 32826059 hsa-mir-19a Infertility, Male Over-expression MIR319A and MIR447A could effectively inhibit the transcription of target genes and lead to male sterile. +transcription factor target 32826059 hsa-mir-447a Infertility, Male Over-expression MIR319A and MIR447A could effectively inhibit the transcription of target genes and lead to male sterile. +other 32825967 hsa-mir-139 Laryngeal Neoplasms 3p in laryngeal cancerin vitro and in vivo. +other 32825947 hsa-mir-185 Carcinoma, Pancreatic Ductal 5p/CBX2 exerted crucial functions in tumorigenesis and progression of PDAC. +other 32825833 hsa-mir-22 Status Epilepticus Taken together, these findings indicate a role for miR-22 in establishing early inflammatory responses to status epilepticus. +other 32825530 hsa-mir-92a Breast Neoplasms 5p). +other 32825530 hsa-mir-29c Breast Neoplasms 5p). +other 32825530 hsa-mir-424 Breast Neoplasms 5p). +other 32825530 hsa-mir-141 Breast Neoplasms 5p). +transcription factor target 32825525 hsa-mir-34a Acute Lung Injury The present study indicates that miR-34a intensified LPS-induced lung injury and inflammation by regulating Klf4 and macrophage polarization, which may serve as a potential therapeutic target for acute lung injury/ARDS. +transcription factor target 32825525 hsa-mir-34a Respiratory Distress Syndrome The present study indicates that miR-34a intensified LPS-induced lung injury and inflammation by regulating Klf4 and macrophage polarization, which may serve as a potential therapeutic target for acute lung injury/ARDS. +transcription factor target 32825525 hsa-mir-34a Lung Injury Inhibition of miR-34a significantly improved lung histology, whereas over-expression of miR-34a worsened the lung injury phenotype. The present study indicates that miR-34a intensified LPS-induced lung injury and inflammation by regulating Klf4 and macrophage polarization, which may serve as a potential therapeutic target for acute lung injury/ARDS. +transcription factor target 32825525 hsa-mir-34a Inflammation The present study indicates that miR-34a intensified LPS-induced lung injury and inflammation by regulating Klf4 and macrophage polarization, which may serve as a potential therapeutic target for acute lung injury/ARDS. +genetics_overexpression_suppress 32825219 hsa-mir-21 Melanoma Overexpression of miR-26b-5p and miR +other 32824922 hsa-mir-612 Thyroid Cancer, Papillary 5p may be a positive regulator of NFE2L2 expression in PTC. +other 32824922 hsa-mir-17 Thyroid Cancer, Papillary 5p may be a positive regulator of NFE2L2 expression in PTC. +lncRNA target 32824921 hsa-mir-146b Adenocarcinoma, Follicular Coupled experimental and computational approaches identified reciprocal dysregulation of miR-146b and miR-451 as important attributes of follicular cell malignant transformation and follicular thyroid cancer progression. +lncRNA target 32824921 hsa-mir-451 Adenocarcinoma, Follicular Coupled experimental and computational approaches identified reciprocal dysregulation of miR-146b and miR-451 as important attributes of follicular cell malignant transformation and follicular thyroid cancer progression. +circulation_biomarker_diagnosis_ns 32824915 hsa-mir-142 Atrial Premature Complexes However, EV extraction methodology affects combined models (semen exosome miRNA signatures plus blood Prostate specific antigen (PSA) concentration for PCa diagnosis) less; specifically our previously described (miR +circulation_biomarker_diagnosis_ns 32824915 hsa-mir-223 Atrial Premature Complexes However, EV extraction methodology affects combined models (semen exosome miRNA signatures plus blood Prostate specific antigen (PSA) concentration for PCa diagnosis) less; specifically our previously described (miR +other 32824820 hsa-let-7 Thyroid Nodule CONCLUSION: The isolation of TPO(+)EVs, followed by RT-qPCR analysis of Let-7 family members, may present a helpful approach to manage follicular nodules in the thyroid gland. +lncRNA target 32824678 hsa-mir-142 Endometriosis 3p based drugs for inhibiting invasive growth of endometriotic cells. +genetics_knock down_promote 32824678 hsa-mir-142 Wiskott-Aldrich Syndrome qPCR revealed that miR3p upregulation in St-T1b cells downregulates Rho-associated protein kinase 2 (ROCK2), cofilin 2 (CFL2), Ras-related C3 botulinum toxin substrate 1 (RAC1), neural Wiskott-Aldrich syndrome protein (WASL), and integrin alpha-V (ITGAV). +other 32824612 hsa-mir-205 Atrial Premature Complexes Here, we studied the influence of radical prostatectomy (RP) on the expression of 12 cell-free miRNAs previously shown as potential markers of PCa (i.e., miR-19b, miR-22, miR-92a, miR-378, miR-425, miR-30e, miR-31, miR-125b, miR-200b, miR-205, miR-375 and miR-660). +other 32824612 hsa-mir-375 Atrial Premature Complexes Here, we studied the influence of radical prostatectomy (RP) on the expression of 12 cell-free miRNAs previously shown as potential markers of PCa (i.e., miR-19b, miR-22, miR-92a, miR-378, miR-425, miR-30e, miR-31, miR-125b, miR-200b, miR-205, miR-375 and miR-660). The comparative expression analysis of the cell-free miRNA ratios between healthy donors and PCa patients revealed miR-125b/miR-30e and miR-375/miR-30e as potential markers for evaluating therapeutic efficacy. +other 32824612 hsa-mir-200 Atrial Premature Complexes Here, we studied the influence of radical prostatectomy (RP) on the expression of 12 cell-free miRNAs previously shown as potential markers of PCa (i.e., miR-19b, miR-22, miR-92a, miR-378, miR-425, miR-30e, miR-31, miR-125b, miR-200b, miR-205, miR-375 and miR-660). +other 32824612 hsa-mir-378 Atrial Premature Complexes Here, we studied the influence of radical prostatectomy (RP) on the expression of 12 cell-free miRNAs previously shown as potential markers of PCa (i.e., miR-19b, miR-22, miR-92a, miR-378, miR-425, miR-30e, miR-31, miR-125b, miR-200b, miR-205, miR-375 and miR-660). +other 32824612 hsa-mir-425 Atrial Premature Complexes Here, we studied the influence of radical prostatectomy (RP) on the expression of 12 cell-free miRNAs previously shown as potential markers of PCa (i.e., miR-19b, miR-22, miR-92a, miR-378, miR-425, miR-30e, miR-31, miR-125b, miR-200b, miR-205, miR-375 and miR-660). +other 32824612 hsa-mir-200b Atrial Premature Complexes Here, we studied the influence of radical prostatectomy (RP) on the expression of 12 cell-free miRNAs previously shown as potential markers of PCa (i.e., miR-19b, miR-22, miR-92a, miR-378, miR-425, miR-30e, miR-31, miR-125b, miR-200b, miR-205, miR-375 and miR-660). +other 32824612 hsa-mir-125b Atrial Premature Complexes Here, we studied the influence of radical prostatectomy (RP) on the expression of 12 cell-free miRNAs previously shown as potential markers of PCa (i.e., miR-19b, miR-22, miR-92a, miR-378, miR-425, miR-30e, miR-31, miR-125b, miR-200b, miR-205, miR-375 and miR-660). The comparative expression analysis of the cell-free miRNA ratios between healthy donors and PCa patients revealed miR-125b/miR-30e and miR-375/miR-30e as potential markers for evaluating therapeutic efficacy. +other 32824612 hsa-mir-19b Atrial Premature Complexes Here, we studied the influence of radical prostatectomy (RP) on the expression of 12 cell-free miRNAs previously shown as potential markers of PCa (i.e., miR-19b, miR-22, miR-92a, miR-378, miR-425, miR-30e, miR-31, miR-125b, miR-200b, miR-205, miR-375 and miR-660). +other 32824612 hsa-mir-1 Atrial Premature Complexes Here, we studied the influence of radical prostatectomy (RP) on the expression of 12 cell-free miRNAs previously shown as potential markers of PCa (i.e., miR-19b, miR-22, miR-92a, miR-378, miR-425, miR-30e, miR-31, miR-125b, miR-200b, miR-205, miR-375 and miR-660). +other 32824612 hsa-mir-22 Atrial Premature Complexes Here, we studied the influence of radical prostatectomy (RP) on the expression of 12 cell-free miRNAs previously shown as potential markers of PCa (i.e., miR-19b, miR-22, miR-92a, miR-378, miR-425, miR-30e, miR-31, miR-125b, miR-200b, miR-205, miR-375 and miR-660). +other 32824612 hsa-mir-92a Atrial Premature Complexes Here, we studied the influence of radical prostatectomy (RP) on the expression of 12 cell-free miRNAs previously shown as potential markers of PCa (i.e., miR-19b, miR-22, miR-92a, miR-378, miR-425, miR-30e, miR-31, miR-125b, miR-200b, miR-205, miR-375 and miR-660). +virus_miRNA 32824160 hcmv-mir-UL112 Human Cytomegalovirus Infections miR-UL112-5p and miR-US4-1 have been found to contribute to immune evasion by targeting the endoplasmic reticulum aminopeptidase 1 (ERAP1), a highly polymorphic key component of antigen processing. +virus_miRNA 32824160 hcmv-mir-US4 Human Cytomegalovirus Infections miR-UL112-5p and miR-US4-1 have been found to contribute to immune evasion by targeting the endoplasmic reticulum aminopeptidase 1 (ERAP1), a highly polymorphic key component of antigen processing. +circulation_biomarker_prognosis_ns 32823863 hsa-mir-155 Breast Neoplasms Starting from 289 potential eligible records, data were examined from 28 studies, comparing tissue and circulating miR-155 expression levels with clinicopathological features and survival rates in BC patients. +other 32823722 hsa-mir-7641 Peritoneal Hyalinizing Vasculopathy Additionally, significantly higher levels of miR-7641 were observed in severe PHV compared to non-PHV peritoneal biopsies. +other 32823253 hsa-mir-29b-2 Mastitis Milk samples (n = 171) were obtained from 113 dairy cows with known disease status (i.e., healthy; n = 23 cows, subclinical mastitis; n = 45 cows, or clinical mastitis; n = 45 cows) and analyzed for the presence of MIR24-2, MIR29B-2, MIR146A, MIR148A, MIR155, MIR181A1, MIR184, and MIR223 expression using the real-time PCR (qPCR) method. The results suggested that MIR29B-2, when used in combination with the California mastitis test (CMT) and days in milk (DIM) data, was applicable for screening and classification of milk samples from cows as healthy, subclinical mastitis, or mastitis. +other 32823253 hsa-mir-181a Mastitis Milk samples (n = 171) were obtained from 113 dairy cows with known disease status (i.e., healthy; n = 23 cows, subclinical mastitis; n = 45 cows, or clinical mastitis; n = 45 cows) and analyzed for the presence of MIR24-2, MIR29B-2, MIR146A, MIR148A, MIR155, MIR181A1, MIR184, and MIR223 expression using the real-time PCR (qPCR) method. +other 32823253 hsa-mir-155 Mastitis Milk samples (n = 171) were obtained from 113 dairy cows with known disease status (i.e., healthy; n = 23 cows, subclinical mastitis; n = 45 cows, or clinical mastitis; n = 45 cows) and analyzed for the presence of MIR24-2, MIR29B-2, MIR146A, MIR148A, MIR155, MIR181A1, MIR184, and MIR223 expression using the real-time PCR (qPCR) method. +other 32823253 hsa-mir-146a Mastitis Milk samples (n = 171) were obtained from 113 dairy cows with known disease status (i.e., healthy; n = 23 cows, subclinical mastitis; n = 45 cows, or clinical mastitis; n = 45 cows) and analyzed for the presence of MIR24-2, MIR29B-2, MIR146A, MIR148A, MIR155, MIR181A1, MIR184, and MIR223 expression using the real-time PCR (qPCR) method. +other 32823253 hsa-mir-148a Mastitis Milk samples (n = 171) were obtained from 113 dairy cows with known disease status (i.e., healthy; n = 23 cows, subclinical mastitis; n = 45 cows, or clinical mastitis; n = 45 cows) and analyzed for the presence of MIR24-2, MIR29B-2, MIR146A, MIR148A, MIR155, MIR181A1, MIR184, and MIR223 expression using the real-time PCR (qPCR) method. +other 32823253 hsa-mir-24-2 Mastitis Milk samples (n = 171) were obtained from 113 dairy cows with known disease status (i.e., healthy; n = 23 cows, subclinical mastitis; n = 45 cows, or clinical mastitis; n = 45 cows) and analyzed for the presence of MIR24-2, MIR29B-2, MIR146A, MIR148A, MIR155, MIR181A1, MIR184, and MIR223 expression using the real-time PCR (qPCR) method. +other 32823253 hsa-mir-223 Mastitis Milk samples (n = 171) were obtained from 113 dairy cows with known disease status (i.e., healthy; n = 23 cows, subclinical mastitis; n = 45 cows, or clinical mastitis; n = 45 cows) and analyzed for the presence of MIR24-2, MIR29B-2, MIR146A, MIR148A, MIR155, MIR181A1, MIR184, and MIR223 expression using the real-time PCR (qPCR) method. +other 32823253 hsa-mir-184 Mastitis Milk samples (n = 171) were obtained from 113 dairy cows with known disease status (i.e., healthy; n = 23 cows, subclinical mastitis; n = 45 cows, or clinical mastitis; n = 45 cows) and analyzed for the presence of MIR24-2, MIR29B-2, MIR146A, MIR148A, MIR155, MIR181A1, MIR184, and MIR223 expression using the real-time PCR (qPCR) method. +circulation_biomarker_diagnosis_up 32823234 hsa-mir-196a Carcinoma, Renal Cell Specifically, the serum expression level of miR-196a-5p was significantly down-regulated in RCC patients with higher Fuhrman grade (p = 0.051). +circulation_biomarker_diagnosis_up 32823234 hsa-mir-196a Endometrial Neoplasms Specifically, the serum expression level of miR-196a-5p was significantly down-regulated in RCC patients with higher Fuhrman grade (p = 0.051). +genetics_overexpression_promote 32823233 hsa-mir-5193 Ovarian Neoplasms Moreover, transfection with miR-5193 mimic in FUT1-overexpression ovarian cancer cells reversed the carcinogenic effect of FUT1. +transcription factor target 32822908 hsa-mir-92b Autoimmune polyendocrinopathy syndrome, type 1 However, the effects of miR-92b-3p on AP process and its mechanism remain not been fully clarified. In conclusion, miR-92b-3p attenuated inflammatory response and autophagy by downregulating TRAF3 and suppressing MKK3-p38 pathway in caerulein-induced AR42J cells, providing a novel avenue for treatment of AP. +other 32822848 hsa-mir-145 Osteosarcoma CONCLUSION: Elevated hsa_circ_0008934 expression promotes the proliferation and migration of osteosarcoma cells by sponging miR5p to enhance E2F3 expression. +other 32822714 hsa-mir-122 Liver Cirrhosis MiR-21 and miR-122 are two miRNAs that their expression changes during fibrosis. +other 32822714 hsa-mir-21 Liver Cirrhosis MiR-21 and miR-122 are two miRNAs that their expression changes during fibrosis. +other 32822323 hsa-mir-122 Liver Diseases MicroRNA-122 effects multiple important factors which regulate the lipid and carbohydrate metabolisms in human non-alcoholic fatty liver disease. +other 32821520 hsa-mir-452 Vitreoretinopathy, Proliferative 3p, and miR-891a-5p increased with the worsening of PVR grading. +other 32821520 hsa-mir-143 Vitreoretinopathy, Proliferative 3p, and miR-891a-5p increased with the worsening of PVR grading. +other 32821520 hsa-mir-361 Vitreoretinopathy, Proliferative 3p, and miR-891a-5p increased with the worsening of PVR grading. +other 32821520 hsa-mir-891a Vitreoretinopathy, Proliferative 3p, and miR-891a-5p increased with the worsening of PVR grading. +other 32821520 hsa-mir-224 Vitreoretinopathy, Proliferative 3p, and miR-891a-5p increased with the worsening of PVR grading. +other 32821513 hsa-mir-23b Diabetic Retinopathy Among these six miRNAs, hsa-miR-23b-3p levels were lower in the anti-VEGF-treated group of PDR patients compared with untreated PDR patients. +target gene 32821248 hsa-mir-502 Stomach Neoplasms miR-502-5p affects gastric cancer progression by targeting PD-L1. +genetics_overexpression_promote 32821247 hsa-mir-15a Prostatic Neoplasms Overexpressing miR-15a in PC cells was sufficient to promote cytotoxicity and proliferation, while inhibit apoptosis of CD8(+) T cells, and also suppressed viability, migration, invasion and EMT while promoted apoptosis of PC cells. +genetics_knock down_promote 32821163 hsa-mir-218 Retinoblastoma 5p mimics blocked the enhancement of cell growth induced by NACC1 overexpression as well as the activation of the AKT/mTOR signaling pathway in RB cells. +genetics_knock down_promote 32821161 hsa-mir-29c Carcinoma, Hepatocellular In addition, downregulation of miR-29c-3p and upregulation of COL1A1 both reversed the effects of TUG1 knockdown on the proliferation, apoptosis, migration, and invasion of HCC cells. +genetics_overexpression_suppress 32821160 hsa-mir-383 Colorectal Neoplasms The overexpression of CREB1 reversed the inhibitory effects of miR-383 accumulation on the proliferation and glycolysis and the promoting impact on the apoptosis of CRC cells. +lncRNA target 32821157 hsa-mir-98 Carcinoma, Hepatocellular 5p inhibition could activate PI3K/AKT pathway, and enhanced sorafenib resistance by regulating the activation of PI3K/AKT pathway in sorafenib-resistant HCC cells. +other 32821139 hsa-mir-503 Obesity Logistic regression analysis suggested that miR-503 was an important related factor associated with an unhealthy metabolic state in overweight/obese subjects. CONCLUSION: miR-503 can be considered as a suitable biomarker to distinguish between the MUO and MHO, which may be a related factor for the incidence of metabolic disorders in overweight/obese subjects. +genetics_knock down_promote 32821123 hsa-mir-708 Colorectal Neoplasms LOXL1-AS1 knockdown along with miR +genetics_knock down_suppress 32821119 hsa-mir-296 Colorectal Neoplasms 5p downregulation or RUNX1 overexpression reversed the anti-proliferation and pro-apoptosis effects caused by circ_0000512 knockdown in CRC cells. +target gene 32821116 hsa-mir-214 Osteosarcoma Upregulation of FTX Promotes Osteosarcoma Tumorigenesis by Increasing SOX4 Expression via miR-214-5p. +other 32821115 hsa-mir-508 Carcinoma, Renal Cell CONCLUSION: In brief, the results of the present study showed that circHIPK3 promoted ccRCC cell proliferation and metastasis by altering miR-5083p/CXCL13 signaling. +other 32821085 hsa-mir-26a Brain Ischemia PURPOSE: This study aimed to explore the role of miR-26a-5p-neuron-restrictive silencing factor (NRSF/REST), Janus kinase-2 (JAK2)-signal transducer and activator of transcription-3 (STAT3) pathway in the protection mechanism of MT against CIRI in vivo and in vitro. CONCLUSION: MT plays a protective role by regulating miR-26a-5p-NRSF and JAK2-STAT3 pathway to improve CIRI autophagy, inflammation and oxidative stress. +exosome 32821084 hsa-mir-146a Cerebral Hemorrhage CONCLUSION: We demonstrated that miR-146a-5p-riched BMSCs-Exos could offer neuroprotection and functional improvements after ICH through reducing neuronal apoptosis, and inflammation associated with the inhibition of microglial M1 polarization by downregulating the expression of IRAK1 and NFAT5. +transcription factor target 32820824 hsa-mir-34c Parkinson Disease Oxidative stress can be considered a strong candidate for neurodegeneration via miR-34c downregulation and pro-apoptotic signalling in respiratory neurons, preceding the functional impairment observed in the 6-OHDA model of PD. +other 32820798 hsa-mir-211 Cystitis "In addition, we demonstrated that CircTHBS1 played a role in the adsorption of miR-211 by ""sponge"" in pCG. Finally, we confirmed the role and mechanism of CircTHBS1/miR-211/CCND2 regulation axis in pCGs." +transcription factor target 32820688 hsa-mir-200b Asthma Method: To explore the role of miR-200a and miR-200b in asthma, miR-200a mimics/inhibitor and miR-200b mimics/inhibitor were employed in A549 cells, respectively. +transcription factor target 32820688 hsa-mir-200a Asthma Method: To explore the role of miR-200a and miR-200b in asthma, miR-200a mimics/inhibitor and miR-200b mimics/inhibitor were employed in A549 cells, respectively. +transcription factor target 32820512 hsa-mir-125a Hypoxia OBJECTIVE: To explore the effect and mechanism of miR-125a-5p targeted regulation of scavenger receptor B1 (Scarb1) gene on anoxia/reoxygenation injury of rat cardiomyocytes. +other 32820503 hsa-mir-145 Chromosome Aberrations With the threshold values of above 9 and 3 for the relative expression of miR-145 and mir3p, respectively, there was no embryo without a chromosomal abnormality. +other 32820503 hsa-mir-886 Chromosome Aberrations With the threshold values of above 9 and 3 for the relative expression of miR-145 and mir3p, respectively, there was no embryo without a chromosomal abnormality. +genetics_GWAS 32820394 hsa-mir-585 Stomach Neoplasms CONCLUSIONS: LINC01436 epigenetically silences miR +genetics_overexpression_promote 32820252 hsa-mir-130a Carcinoma, Non-Small-Cell Lung Notably, miR-130a-5p overexpression suppressed NSCLC cell proliferation and increased apoptosis in vitro and in vivo, and this effect was reversed by KTN1-AS1 overexpression. +lncRNA target 32820249 hsa-mir-450a Glioma Therefore, we conclude that miR-450a-5p synergizes with gefitinib to inhibit the glioma tumorigenesis through inducing autophagy by regulating the EGFR-induced PI3K/AKT/mTOR signaling pathway, thereby enhancing the drug sensitivity of gefitinib. +genetics_overexpression_promote 32820233 hsa-mir-218 Urinary Bladder Neoplasms Overexpressed miR +transcription factor target 32819715 hsa-mir-483 Esophageal Squamous Cell Carcinoma 5p as an oncogene facilitated EC cell proliferation, migration and invasion by targeted silencing KCNQ1, which is likely to provide a basis for further exploring the molecular mechanism of EC progression. +transcription factor target 32819600 hsa-mir-29a Liver Cirrhosis CONCLUSION: MiR-29a-3p regulates hepatic stellate cell proliferation and hepatic fibrosis pathogenesis by targeting PIK3R3 expression and modulating the PI-3K/AKT signaling. +genetics_knock down_promote 32819595 hsa-mir-1 Uterine Cervical Neoplasms 3p silencing effectively offset the impacts of MIR31HG knockdown on cervical carcinoma cell progression. +circulation_biomarker_diagnosis_ns 32819588 hsa-mir-9 Carcinoma, Renal Cell 5) is highly expressed in the serum of renal cancer patients with advanced (tumor size - node - metastasis) TNM stage and Fuhrman grade. +transcription factor target 32819575 hsa-mir-27a Glomerulonephritis, IGA Accordingly, in this study we found that miR-27a-3p is upregulated in IgAN kidney tissues in addition to human podocytes and tubule epithelial HK2 but not mesangial cells. Our results therefore suggested that miR-27a-3p might be associated with the pathophysiology of IgAN and may represent a potential target for further studies related to IgAN mechanism or therapeutics. +transcription factor target 32819575 hsa-mir-27a Inflammation Accordingly, in this study we found that miR-27a-3p is upregulated in IgAN kidney tissues in addition to human podocytes and tubule epithelial HK2 but not mesangial cells. Our results therefore suggested that miR-27a-3p might be associated with the pathophysiology of IgAN and may represent a potential target for further studies related to IgAN mechanism or therapeutics. +lncRNA target 32819442 hsa-mir-380 Spinal Cord Injuries CONCLUSIONS: We concluded that HIF-1alpha reduced inflammation in spinal cord injury via miR +lncRNA target 32819407 hsa-mir-195 Brain Damage, Chronic CONCLUSIONS: Our findings conclude that downregulation of miR-195 in the hippocampus is involved in CBH-induced microglial/macrophage polarization towards M1 phenotype by governing communication between neurons and microglia through the regulation of CX3CL1 and CX3CR1 signaling. This indicates that miR-195 may provide a new strategy for clinical prevention and treatment of CBH. +exosome 32819370 hsa-mir-1246 Pancreatic Carcinoma We have recently demonstrated that certain miRNA species are selectively and highly enriched in pancreatic cancer exosomes with miR-1246 being the most abundant. +other 32818938 hsa-mir-31 Breast Neoplasms Moreover, the development and progression of breast cancer may involve miR-331. +other 32818819 hsa-mir-424 Acute Lung Injury Overall, in vivo and in vitro results suggested that THRIL accelerates sepsis-induced lung injury by sponging miR-424 and further restoring ROCK2. +other 32818819 hsa-mir-424 Sepsis Overall, in vivo and in vitro results suggested that THRIL accelerates sepsis-induced lung injury by sponging miR-424 and further restoring ROCK2. +genetics_knock down_promote 32818704 hsa-mir-200b Calcinosis SNHG29 overexpression and miR-200b-3p knockdown significantly suppressed osteoblast-related factors (RUNX2 and BMP2), accompanied by activation of the alpha-Klotho/FGFR1/FGF23 axis, further inhibiting the formation of calcified nodules. +lncRNA target 32818704 hsa-mir-200b Ventricular Premature Complexes CONCLUSION: Our study is the first to demonstrate that SNHG29 could inhibit VSMC calcification by downregulating miR-200b-3p to activate the alpha-Klotho/FGFR1/FGF23 axis, suggesting SNHG29 as a novel therapeutic target for VC-associated diseases. +genetics_knock down_promote 32818670 hsa-mir-539 Carcinoma, Hepatocellular We also found knockdown of TP73-AS1 or overexpression of miR-539 inhibited HCC tumor growth and M2 macrophage infiltration in vivo. +genetics_GWAS 32818653 hsa-mir-421 Pancreatic Carcinoma Our findings indicated that K73-03 inhibited the mitochondrial function that led to inducing autophagy and apoptosis through epigenetic SPINK1 down-regulation via miR-421 up-regulation in pancreatic cancer. +lncRNA target 32818571 hsa-mir-552 Lipid Metabolism Disorders 3p suggest that it might be a potential therapeutic target for the treatment of glycolipid metabolic disease. +lncRNA target 32818384 hsa-mir-126 Coronary Disease This interaction leads to sequestration of miR-126 from its target E2F transcription factor 3 (E2F3), contributing to E2F3 suppression in CHD. +genetics_knock down_promote 32818383 hsa-mir-4319 Breast Neoplasms DANCR knockdown inhibited breast cancer development through regulating miR-4319. +lncRNA target 32818322 hsa-mir-92b Inflammation Hence, miR-92b-3p abated apoptosis, mitochondrial dysfunction and inflammatory responses induced by OGD/R by targeting TRAF3. +lncRNA target 32818316 hsa-mir-497 Uterine Cervical Neoplasms 5p/CCNE1 signalling pathway is a promising target for cervical cancer treatment in the future. +circulation_biomarker_diagnosis_ns 32818115 hsa-mir-126 Macular Degeneration The biomarker potential of three miRNAs (miR-126, miR-19a, and miR-410) was confirmed by qRT-PCR, with significantly increased quantities in serum of AMD patients compared with healthy controls. Conclusions Increased quantities of miR-126, miR-410, and miR-19a in serum from AMD patients indicate that these miRNAs could potentially serve as diagnostic AMD biomarkers. +circulation_biomarker_diagnosis_ns 32818115 hsa-mir-19a Macular Degeneration The biomarker potential of three miRNAs (miR-126, miR-19a, and miR-410) was confirmed by qRT-PCR, with significantly increased quantities in serum of AMD patients compared with healthy controls. Conclusions Increased quantities of miR-126, miR-410, and miR-19a in serum from AMD patients indicate that these miRNAs could potentially serve as diagnostic AMD biomarkers. +circulation_biomarker_diagnosis_ns 32818115 hsa-mir-410 Macular Degeneration The biomarker potential of three miRNAs (miR-126, miR-19a, and miR-410) was confirmed by qRT-PCR, with significantly increased quantities in serum of AMD patients compared with healthy controls. Conclusions Increased quantities of miR-126, miR-410, and miR-19a in serum from AMD patients indicate that these miRNAs could potentially serve as diagnostic AMD biomarkers. +genetics_overexpression_promote 32817745 hsa-mir-876 Stomach Neoplasms 5p overexpression-induced effects on GC cells. +transcription factor target 32817347 hsa-mir-217 Inflammation Inducible miR-217 suppresses the production of inflammatory cytokines and type I IFN by targeting TAK1, thereby avoiding excessive inflammation. +tissue_expression_ns 32816902 hsa-let-7 Complement Component 7 Deficiency Haploinsufficiency of CHD7 in humans causes CHARGE syndrome and attenuation of let-7 function may be an effective method for treating CHD7 deficiency. +other 32816902 hsa-let-7 Coproporphyria, Hereditary Using a let-7 sponge construct to sequester let-7 miRNAs, we found that endogenous let-7 miRNAs are essential for limiting the self-renewal of HC progenitor cells. +tissue_expression_ns 32816902 hsa-let-7 Coronary Disease Haploinsufficiency of CHD7 in humans causes CHARGE syndrome and attenuation of let-7 function may be an effective method for treating CHD7 deficiency. +tissue_expression_ns 32816902 hsa-let-7 CHARGE Syndrome Haploinsufficiency of CHD7 in humans causes CHARGE syndrome and attenuation of let-7 function may be an effective method for treating CHD7 deficiency. +genetics_knock down_promote 32816152 hsa-mir-27a Cholangiocarcinoma Furthermore, miR-27a overexpression promoted CCA cell proliferation, migration, and invasion, whereas knockdown of miR-27a suppressed cell proliferation, migration, and invasion. +other 32816128 hsa-mir-181b Perinatal Asphyxia DIM also downregulated the mRNA expression of HIF1A-regulated Bnip3 and Hif1a which is a hypoxic marker, and the expression of miR-181b which is an indicator of perinatal asphyxia. +other 32815784 hsa-mir-18a Ischemic Stroke Bioinformatics analysis indicated that TLR8 was up-regulated in patients with ischemic stroke than that in healthy control, and miR-18a-5p was the upstream regulatory of TLR8. +transcription factor target 32815642 hsa-mir-124 Inflammatory Bowel Diseases In summary, Rab27A might modulate the miR3p/STAT3/RelA axis to promote apoptosis and ROS production in inflammatory colonic cells, suggesting that Rab27A as a novel therapeutic target for the prevention and treatment of UC patients. +lncRNA target 32815572 hsa-mir-9 Ischemic Stroke Then, in AIS patients, interleukin-6 and intercellular adhesion molecule 1 (ICAM1), as well as microRNA (miR) target of lncRNA HUCL (miR-9 and miR-195), were detected by enzyme-linked immunosorbent assay and RT-qPCR, respectively. +genetics_overexpression_promote 32815529 hsa-mir-214 Reperfusion Injury, Cerebral Ischemia However, overexpression of lncRNA NEAT1 repressed the remission effect of miR-214 on cerebral ischemia-reperfusion-induced damage and inhibited the production of PI3K, Akt, p-Akt, and VEGF by rescuing the levels of PTEN. +transcription factor target 32815005 hsa-mir-143 Diabetes Mellitus, Type 1 3p could function in the pathogenesis of ADM by modulating the inflammatory reaction through FOSL2. +circulation_biomarker_prognosis_up 32814996 hsa-mir-1975 Influenza, Human Our results reveal that circulating miR-1975 has great potential to serve as a biomarker for predicting prognosis in patients infected with influenza virus. +lncRNA target 32814818 hsa-mir-99b Cardiomyopathies These results suggest that miR-99b-3p contributes to Ang II-induced cardiac fibrosis at least partially through GSK-3beta. +lncRNA target 32814766 hsa-mir-141 Carcinoma, Renal Cell This study, for the first time, deciphered the role of CDKN2B-AS1/miR-141/Cyclin D axis in RCC and highlights this network as a promising therapeutic target for the regulation of EMT driven metastasis in RCC. +lncRNA target 32814091 hsa-mir-134 Hypoxia-Ischemia, Brain 5p/KPNA3 axis mediates hypoxic-ischemic brain damage and neuronal death, thus presenting a potential therapeutic target for the treatment of human newborns at risk for HIBD. +circulation_biomarker_diagnosis_ns 32813736 hsa-mir-26a Atrial Fibrillation Six of these plasma microRNAs were significantly associated with incident AF, including 4 also associated with prevalent AF (microRNAs 106b, 26a-5p, 484, 20a-5p). CONCLUSIONS: Circulating microRNAs 106b, 26a-5p, 484, 20a-5p are associated with atrial remodeling and AF. +circulation_biomarker_diagnosis_ns 32813736 hsa-mir-106b Atrial Fibrillation Six of these plasma microRNAs were significantly associated with incident AF, including 4 also associated with prevalent AF (microRNAs 106b, 26a-5p, 484, 20a-5p). CONCLUSIONS: Circulating microRNAs 106b, 26a-5p, 484, 20a-5p are associated with atrial remodeling and AF. +genetics_knock down_promote 32812642 hsa-mir-186 Cholangiocarcinoma The overexpression of lncRNA PVT1 and SEMA4D, as well as the inhibition of miR-186 led to elevated CCA cell proliferation, migration and invasion. +transcription factor target 32812641 hsa-mir-29b Cardiomyopathies The present study aimed to investigate the role and mechanism of miR-29b-3p in cardiac fibrosis after MI. CONCLUSION: miR-29b-3p degraded the pro-fibrosis effect induced by TGF-beta1 via targeting FOS, providing a prospective therapeutic avenue for cardiac fibrosis after MI. +other 32812639 hsa-mir-34c Pulmonary Disease, Chronic Obstructive The levels of TUG1 and BRD4 were significantly up-regulated, and the level of miR-34c was apparently down-regulated in COPD patients or CSE-treated BEAS-2B cells. +genetics_GWAS 32812451 hsa-mir-146a Diabetes Mellitus, Type 2 OBJECTIVE: Circulating miR-146a is aberrantly expressed in patients with type 2 diabetes (T2D), probably resulting from gene polymorphisms. +other 32812418 hsa-mir-122 Hepatitis B, Chronic This assay achieved linear calibration curves of between 0.5 aM and 1 pM for microRNA-122 (miRNA-122) and between 1 aM and 1 pM for HBV-T (a DNA fragment from hepatitis B virus). +circulation_biomarker_diagnosis_ns 32812418 hsa-mir-122 Carcinoma, Hepatocellular Furthermore, the procedure was applied to determine miRNA-122 and HBV-T in genuine serum samples from hepatocellular carcinoma patients. +exosome 32812305 hsa-mir-103a Vulvar Neoplasms CONCLUSION: Our findings suggested exosomal UCA1 derived from CAF conferred VSCC cell resistance to CDDP in vitro and in vivo at least partly through the miR-103a/WEE1 axis, highlighting a novel therapeutic method for improving the clinical benefits of CDDP chemotherapy in VSCC patients. +circulation_biomarker_diagnosis_ns 32811874 hsa-mir-34a Diabetes Mellitus Subsequently, among these miRs we selected and measured plasma miR-34a, -224 and -452 in diabetic HFpEF patients (n = 53) and controls (n = 52). We conclude that plasma miR-34a, -224 and -452 display an association with the microvascular injury marker Ang-2 and are particularly targeted to women with LVDD or HFpEF. +circulation_biomarker_diagnosis_ns 32811874 hsa-mir-34a Ventricular Dysfunction, Left Subsequently, among these miRs we selected and measured plasma miR-34a, -224 and -452 in diabetic HFpEF patients (n = 53) and controls (n = 52). We conclude that plasma miR-34a, -224 and -452 display an association with the microvascular injury marker Ang-2 and are particularly targeted to women with LVDD or HFpEF. +circulation_biomarker_diagnosis_ns 32811874 hsa-mir-34a Heart Failure Subsequently, among these miRs we selected and measured plasma miR-34a, -224 and -452 in diabetic HFpEF patients (n = 53) and controls (n = 52). We conclude that plasma miR-34a, -224 and -452 display an association with the microvascular injury marker Ang-2 and are particularly targeted to women with LVDD or HFpEF. +lncRNA target 32811869 hsa-mir-373 Esophageal Squamous Cell Carcinoma 3p to up-regulate AKT1 mRNA level, and may serve as a potential therapeutic target and a prognostic biomarker for ECa patients. +transcription factor target 32811812 hsa-mir-1307 Colorectal Neoplasms In summary, our current study revealed that rs7911488-T allele led to over-expression of miR-1307, which inhibited PRRX1 and consequently promoted the proliferation and migration of CRC cells. +lncRNA target 32811810 hsa-mir-380 Triple Negative Breast Neoplasms 3p/BAALC in accelerating TNBC development, indicating new promising targets for TNBC treatment. +other 32811699 hsa-mir-498 psoriasis 1 5p were significantly down-regulated in psoriasis patients when compared with the control group (p<0.05). +other 32811699 hsa-mir-1266 psoriasis 1 5p were significantly down-regulated in psoriasis patients when compared with the control group (p<0.05). +other 32811699 hsa-mir-22 psoriasis 1 5p were significantly down-regulated in psoriasis patients when compared with the control group (p<0.05). +other 32811699 hsa-mir-515 psoriasis 1 5p were significantly down-regulated in psoriasis patients when compared with the control group (p<0.05). +other 32811699 hsa-mir-155 psoriasis 1 5p were significantly down-regulated in psoriasis patients when compared with the control group (p<0.05). +other 32811699 hsa-mir-21 psoriasis 1 5p were significantly down-regulated in psoriasis patients when compared with the control group (p<0.05). +other 32811699 hsa-mir-17 psoriasis 1 5p were significantly down-regulated in psoriasis patients when compared with the control group (p<0.05). +other 32811699 hsa-mir-193b psoriasis 1 5p were significantly down-regulated in psoriasis patients when compared with the control group (p<0.05). +other 32811699 hsa-let-7d psoriasis 1 5p were significantly down-regulated in psoriasis patients when compared with the control group (p<0.05). +other 32811699 hsa-mir-126 psoriasis 1 5p were significantly down-regulated in psoriasis patients when compared with the control group (p<0.05). +other 32811699 hsa-let-7c psoriasis 1 5p were significantly down-regulated in psoriasis patients when compared with the control group (p<0.05). +other 32811699 hsa-mir-106b psoriasis 1 5p were significantly down-regulated in psoriasis patients when compared with the control group (p<0.05). +other 32811699 hsa-mir-24 psoriasis 1 5p were significantly down-regulated in psoriasis patients when compared with the control group (p<0.05). +other 32811699 hsa-mir-181a psoriasis 1 5p were significantly down-regulated in psoriasis patients when compared with the control group (p<0.05). +other 32811699 hsa-mir-142 psoriasis 1 5p were significantly down-regulated in psoriasis patients when compared with the control group (p<0.05). +other 32811699 hsa-mir-222 psoriasis 1 5p were significantly down-regulated in psoriasis patients when compared with the control group (p<0.05). +other 32811699 hsa-mir-26a psoriasis 1 5p were significantly down-regulated in psoriasis patients when compared with the control group (p<0.05). +other 32811699 hsa-mir-424 psoriasis 1 5p were significantly down-regulated in psoriasis patients when compared with the control group (p<0.05). +other 32811699 hsa-mir-369 psoriasis 1 5p were significantly down-regulated in psoriasis patients when compared with the control group (p<0.05). +other 32811699 hsa-mir-16 psoriasis 1 5p were significantly down-regulated in psoriasis patients when compared with the control group (p<0.05). +other 32811699 hsa-mir-205 psoriasis 1 5p were significantly down-regulated in psoriasis patients when compared with the control group (p<0.05). +lncRNA target 32811645 hsa-mir-130b Nasopharyngeal Neoplasms In conclusion, our results firstly suggested that NEF may enhanced Taxol sensitivity in NPC Taxol-resistant cell lines through inhibition of EMT which mediated by miR-130b-5p downregulation in vitro and in vivo. +genetics_overexpression_promote 32810829 hsa-mir-497 Meningioma FINDINGS: We found that miR-497~195 cluster expression in meningioma decreases with increasing malignancy grade, and that Cyclin D1 overexpression correlated with downregulation of the miR-497~195 cluster. +other 32810693 hsa-mir-29c Breast Neoplasms RP11-480I12.5-004 Promotes Growth and Tumorigenesis of Breast Cancer by Relieving miR-29c-3p-Mediated AKT3 and CDK6 Degradation. +target gene 32810692 hsa-mir-135a Osteosarcoma Targeting the miR-135a-5p/LCP1 axis may have potential in treating OS. +other 32810522 hsa-mir-7 Necrosis CONCLUSION: Our results extended the mechanism of miR-7 antitumor role in rhabdomyosarcoma cancer, and provided potential implications for its therapy. +other 32810522 hsa-mir-7 Hand, Foot and Mouth Disease CONCLUSION: Our results extended the mechanism of miR-7 antitumor role in rhabdomyosarcoma cancer, and provided potential implications for its therapy. +genetics_overexpression_promote 32810511 hsa-mir-616 Prostatic Neoplasms In addition, rescue assays revealed that PTEN silencing (or miR-616 mimics) blocked the tumor-suppressing effects of hsa_circ_0007494 overexpression on PCa progression. Together, our findings indicate that hsa_circ_0007494 suppresses PCa by forming a negative regulatory network including hsa_circ_0007494/miR-616/PTEN. +transcription factor target 32810491 hsa-mir-181a Glioblastoma Considering that, the current study was aimed to investigate the function of miR-181a in human glioblastoma cells in combination with carmustine. In conclusion, the findings of this study suggest that miR-181a replacement, regarding its tumor-suppressive effects and sensitization of glioblastoma cells to carmustine, could be considered as a potential therapeutic strategy to improve the efficiency of glioblastoma chemotherapy. +lncRNA target 32810308 hsa-mir-495 Coronary Disease Retraction: 'microRNA-495 alleviates endothelial cell inflammatory injury in coronary heart disease via blockade of the NF-?B pathway by targeting RALB', by Feng-Feng Lv, Zheng Lian, Li-Qiu Yan, Gang Wang, Zhe Li, J Cell Physiol.: The above article, published online on 18 August 2020 in Wiley Online Library (https://onlinelibrary.wiley.com/doi/full/10.1002/ has been retracted by agreement between the journal's Editor in Chief, Prof. +other 32810279 hsa-mir-124a Arthritis The 'lncRNA-H19-miR-124a-CDK2/MCP-1' axis plays an important role in LXR anti-arthritis. +other 32810257 hsa-mir-122 Hepatitis C Hepatitis C virus (HCV) replication requires annealing of a liver specific small-RNA, miR-122 to 2 sites on 5' untranslated region (UTR). +other 32809970 hsa-mir-221 Hereditary Angioedema Types I and II We also identified a TNF-alpha/NF-kappaB/miR-221 pathway that downregulated C-KIT expression in ICCs in the colon affected by HAEC. +lncRNA target 32809800 hsa-mir-1 Squamous Cell Carcinoma of Head and Neck "So, in this work, we designed a point-of-care testing (POCT) platform for the detection of OSCC-associated salivary hsa-miRNA 31-5p (miR-31) via the cascade signal amplification of ""invading stacking primer"" (IS-primer) amplification reaction (ISAR), CRISPR/Cas12a, and dual-mode paper-based strip (dm-Strip)." +genetics_overexpression_promote 32809144 hsa-mir-1179 Mouth Neoplasms The results showed miR-1179 to be significantly (p < 0.05) overexpressed in all the oral cancer cell lines relative to normal cells. +other 32809092 hsa-mir-126 Endometriosis This study further investigated the regulation of MALAT1-miR5p-CREB1 axis in the pathological process of endometriosis. +genetics_overexpression_promote 32808846 hsa-mir-136 Carcinoma, Renal Cell Moreover, the promotive effect of overexpressed CRNDE on RCC cells could be blocked by miR +circRNA target 32808744 hsa-mir-4458 Carcinoma, Non-Small-Cell Lung Circ-PRMT5 promoted DDP resistance via REV3L by sponging miR-4458 in NSCLC, thus providing a novel therapeutic strategy for patients with NSCLC. +lncRNA target 32808728 hsa-mir-378a Adenocarcinoma of Lung To summarize, ACTA2-AS1 suppresses the malignant processes of LUAD cells through sequestering miR-378a-3p and miR-4428 to augment SOX7 expression. +lncRNA target 32808728 hsa-mir-4428 Adenocarcinoma of Lung To summarize, ACTA2-AS1 suppresses the malignant processes of LUAD cells through sequestering miR-378a-3p and miR-4428 to augment SOX7 expression. +lncRNA target 32808708 hsa-mir-125a Breast Neoplasms Our results indicated CERS6-AS1 promote BC cell proliferation and inhibit cell apoptosis via sponging miR-125a-5p to upregulate BAP1 expression. +genetics_knock down_promote 32808701 hsa-mir-541 Carcinoma, Hepatocellular 3p inhibition mitigated the effects of circIL4R knockdown on HCC cells. +lncRNA target 32808668 hsa-mir-491 Precursor Cell Lymphoblastic Leukemia-Lymphoma In conclusion, VPS9D1-AS1 contributed to ALL cell proliferation through miR +lncRNA target 32808668 hsa-mir-214 Precursor Cell Lymphoblastic Leukemia-Lymphoma In conclusion, VPS9D1-AS1 contributed to ALL cell proliferation through miR +other 32808648 hsa-mir-22 Arthritis, Rheumatoid Present investigation was aimed at developing methotrexate (MTX) and miR-22 mimics-loaded lipid nanoparticles for the effective treatment of rheumatoid arthritis. Present study clearly highlights the potential of lipid nanoparticles-based synergistic combination of MTX and miR-22 in achieving higher therapeutic response in rheumatoid arthritis treatment. +lncRNA target 32808542 hsa-mir-152 Parkinson Disease Thus, knocking down TUG1 might have a protective effect on PD through the miR +other 32808450 hsa-mir-296 Polycystic Ovary Syndrome Collectively, we preliminarily characterized the role and possible insights of circPSMC3/miR3p/PTEN axis in the proliferation and apoptosis of KGN cells. +exosome 32808389 hsa-mir-145 Hemorrhagic Fever With Renal Syndrome Concluding, this study indicated that exosomes released by HTNV-infected HUVECs were able to transfer active molecules, miR5p as a proving sample, to mediate novel anti-HTNV activity in the neighboring uninfected cells, which will help us to explore new strategies for the treatment of infectious disease utilizing exosomes with miRNA. +transcription factor target 32808351 hsa-mir-182 Brain Ischemia We demonstrated for the first time that cerebral ischemia leads to a significant progressive increase in miR-182 after pMCAO, and bEnd.3 cells are the primary target cells of miR-182. Thus, miR-182 may be a potential target for the treatment of BBB disruption during cerebral ischemia. +exosome 32808032 hsa-mir-15a Lung Neoplasms Low expression of miR-15a-5p was also found in lung cancer tissues and cell lines, suggesting that miR-15a-5p may have an anti-tumor role. This study elucidated a novel regulatory mechanism that apelin may promote proliferation and invasion of lung cancer cells by inhibiting miR-15a-5p encapsulated in exosomes. +other 32807750 hsa-mir-144 Irritable Bowel Syndrome Our previous report determined that miR-144 is a key regulator of intestinal epithelial permeability in irritable bowel syndrome with diarrhea (IBS-D) rats. +lncRNA target 32807692 hsa-mir-9 Colorectal Neoplasms CONCLUSION: Circ-SMARCA5 functions as a tumor suppressor by upregulating ARID4B expression via sponging miR3p, and thereby inhibited CRC progression. +transcription factor target 32807493 hsa-mir-660 Carcinoma, Hepatocellular 5p/YWHAH axis in HCC and provided potential targets for treating HCC. +other 32807146 hsa-mir-33a Non-alcoholic Fatty Liver Disease The hepatic expression level of SREBP2, HMGCR and miR-33a were significantly down-regulated, while CYP7A1 was induced by MLF treatment. +other 32807146 hsa-mir-33a Cholestasis The hepatic expression level of SREBP2, HMGCR and miR-33a were significantly down-regulated, while CYP7A1 was induced by MLF treatment. +lncRNA target 32806571 hsa-mir-203a Sarcoma 5p and the tumor suppressor-miR miR-203a-3p exhibit an association with STS patient prognosis and are suggested as candidates for risk assessment. +lncRNA target 32806571 hsa-mir-155 Sarcoma 5p and the tumor suppressor-miR miR-203a-3p exhibit an association with STS patient prognosis and are suggested as candidates for risk assessment. +other 32806499 hsa-mir-486 Blood Platelet Disorders 3p) that showed a sensitivity expression pattern due to biological platelet changes during storage, confirmed by additional quantitative real-time polymerase chain reaction (qPCR) validation on 100 PC units from 500 healthy donors. +other 32806499 hsa-mir-103a Blood Platelet Disorders 3p) that showed a sensitivity expression pattern due to biological platelet changes during storage, confirmed by additional quantitative real-time polymerase chain reaction (qPCR) validation on 100 PC units from 500 healthy donors. +other 32806499 hsa-mir-181a Blood Platelet Disorders 3p) that showed a sensitivity expression pattern due to biological platelet changes during storage, confirmed by additional quantitative real-time polymerase chain reaction (qPCR) validation on 100 PC units from 500 healthy donors. +other 32806499 hsa-mir-221 Blood Platelet Disorders 3p) that showed a sensitivity expression pattern due to biological platelet changes during storage, confirmed by additional quantitative real-time polymerase chain reaction (qPCR) validation on 100 PC units from 500 healthy donors. +other 32806499 hsa-mir-92a Blood Platelet Disorders 3p) that showed a sensitivity expression pattern due to biological platelet changes during storage, confirmed by additional quantitative real-time polymerase chain reaction (qPCR) validation on 100 PC units from 500 healthy donors. +other 32806499 hsa-mir-151a Blood Platelet Disorders 3p) that showed a sensitivity expression pattern due to biological platelet changes during storage, confirmed by additional quantitative real-time polymerase chain reaction (qPCR) validation on 100 PC units from 500 healthy donors. +lncRNA target 32805387 hsa-mir-132 Acute Lung Injury 3p/FOXO3/NF-kappaB axis, providing a promising therapeutic target for ALI. +other 32805314 hsa-mir-124 COVID-19 We have predicted a ceRNA network involving one miRNA (miR3p), one mRNA (Ddx58), one lncRNA (Gm26917) and two circRNAs (Ppp1r10, C330019G07RiK) in SARS-CoV infected cells. +other 32805255 hsa-mir-874 Hypertension, Pulmonary These findings provide insight into the contribution of the miR5p/Sirt 3 cascade with regard to changes in autophagy and proliferation associated with PH. +lncRNA target 32805088 hsa-mir-181b Breast Neoplasms CONCLUSION: Our work demonstrated the carcinogenic activity of FTO in promoting the invasion and migration of breast cancer cells via the FTO/miR-181b-3p/ARL5B signaling pathway. +other 32804708 hsa-mir-200c Melanoma Compared to lung metastases, liver metastases had greater than twofold upregulation of four miRs, and 4.2-fold downregulation of miR-200c-3p (P < 0.0081). +circulation_biomarker_diagnosis_ns 32804511 hsa-mir-182 high grade glioma The feasibility of the method for sensitive detection of the expression levels of miRNA-182 from serum samples of glioma patients at different stages was demonstrated. +transcription factor target 32804340 hsa-mir-429 Aicardi-Goutieres syndrome 5 Targeting the miRYAP pathway could be exploited for therapeutic strategies for age-related impairment of sWAT browning. +exosome 32804324 hsa-mir-21 Peritoneal Neoplasms METHODS: In 74 patients with advanced GC who underwent staging laparoscopy, exosomes were isolated from peritoneal fluid and expression levels of miR +exosome 32804324 hsa-mir-29b Peritoneal Neoplasms METHODS: In 74 patients with advanced GC who underwent staging laparoscopy, exosomes were isolated from peritoneal fluid and expression levels of miR +exosome 32804324 hsa-mir-21 Stomach Neoplasms METHODS: In 74 patients with advanced GC who underwent staging laparoscopy, exosomes were isolated from peritoneal fluid and expression levels of miR +exosome 32804324 hsa-mir-223 Stomach Neoplasms METHODS: In 74 patients with advanced GC who underwent staging laparoscopy, exosomes were isolated from peritoneal fluid and expression levels of miR +exosome 32804324 hsa-mir-223 Peritoneal Neoplasms METHODS: In 74 patients with advanced GC who underwent staging laparoscopy, exosomes were isolated from peritoneal fluid and expression levels of miR +exosome 32804324 hsa-mir-29b Stomach Neoplasms METHODS: In 74 patients with advanced GC who underwent staging laparoscopy, exosomes were isolated from peritoneal fluid and expression levels of miR +lncRNA target 32804155 hsa-mir-214 Diabetic Nephropathies Together, these results identify the p53/miR-214/ULK1 axis in autophagy impairment in diabetic kidneys, pinpointing possible therapeutic targets for DKD. +lncRNA target 32804119 hsa-mir-221 Leukemia, Myeloid, Acute CONCLUSIONS TUG1 silencing retarded viability and promoted apoptosis of AML cells via regulating miR +lncRNA target 32803914 hsa-mir-34a Osteolysis CONCLUSION: The miR-34a carried by ADEs reduced the polarization of M1-type macrophages by targeting macrophage NLRP3 during Ti particle-induced osteolysis. +lncRNA target 32803763 hsa-mir-185 Glioma 5p/DNMT1/mTOR signaling, which may provide a new target for the diagnosis and therapy of glioma. +other 32803682 hsa-mir-146a Lupus Nephritis We have identified a relevant biological miR-146a-TRAF6 axis association in LN renal fibrosis progression. +lncRNA target 32803651 hsa-let-7a Pulmonary Arterial Hypertension LincRNA-COX2/miR-let-7a/STAT3 axis might be considered as a novel target to treat PAH. +lncRNA target 32803522 hsa-mir-874 Glioma The present study indicated that miR-874 inhibited cell proliferation, migration, and invasion of glioma cells and might be a novel prognostic biomarker and potential therapeutic target for glioma. +transcription factor target 32803505 hsa-mir-193b Pre-Eclampsia Integration of the miRNA and RNA sequencing expression data revealed 10 candidate gene targets for miR-193b-5p across all patient groups (PE only, IUGR only, PE IUGR). These findings suggest that miR-193b-5p may contribute to trophoblast dysfunction observed in pregnancy complications such as PE and IUGR. +transcription factor target 32803505 hsa-mir-193b Fetal Growth Retardation Integration of the miRNA and RNA sequencing expression data revealed 10 candidate gene targets for miR-193b-5p across all patient groups (PE only, IUGR only, PE IUGR). These findings suggest that miR-193b-5p may contribute to trophoblast dysfunction observed in pregnancy complications such as PE and IUGR. +other 32803488 hsa-mir-20b Phyllodes Tumor, Breast CONCLUSION: The study demonstrated the promising potential of applying microRNA20b as a prognostic biomarker in PT patients. +other 32802851 hsa-mir-150 Osteoporosis The results of the logistic regression analysis indicated that in females, higher age and lower miR195 (odds ratio: 0.45, 95% confidential interval: 0.03-0.98) were significant risk factors for lower BMD, while the presence of a smoking habit and lower miR150 (odds ratio: 1.35, 95% confidential interval: 1.02-1.79) were significant risk factors for osteoporosis. +other 32802851 hsa-mir-195 Osteoporosis The results of the logistic regression analysis indicated that in females, higher age and lower miR195 (odds ratio: 0.45, 95% confidential interval: 0.03-0.98) were significant risk factors for lower BMD, while the presence of a smoking habit and lower miR150 (odds ratio: 1.35, 95% confidential interval: 1.02-1.79) were significant risk factors for osteoporosis. +lncRNA target 32802844 hsa-mir-200b Endometriosis CONCLUSION: The predicted target genes and molecular regulatory network of miR-200b-3p in endometriosis not only revealed its biological function but also provided a valuable guideline for further research. +other 32802839 hsa-mir-21 Adenocarcinoma of Lung 3p-RALGPS2) might be potential biomarkers for the prognosis and treatment of LUAD. +other 32802839 hsa-mir-377 Adenocarcinoma of Lung 3p-RALGPS2) might be potential biomarkers for the prognosis and treatment of LUAD. +other 32802839 hsa-mir-326 Adenocarcinoma of Lung 3p-RALGPS2) might be potential biomarkers for the prognosis and treatment of LUAD. +lncRNA target 32802247 hsa-mir-375 Rhinitis, Allergic mediated regulation of ILC2 cells through TSLP, providing new potential treatment target for AR. +lncRNA target 32802198 hsa-mir-4497 Lung Neoplasms Results: We found that radiation can trigger disassemble of Mediator complex via silencing of MED13L by miR-4497 in NSCLC. +lncRNA target 32802189 hsa-mir-17 Diabetes Mellitus, Type 2 miR-17 is a positive regulator, whereas miR-200a is a negative regulator of insulin signaling in skeletal muscle, and both miRNAs have the potential to become therapeutic targets for preventing and treating insulin resistance or type 2 diabetes. +lncRNA target 32802189 hsa-mir-200a Diabetes Mellitus, Type 2 miR-17 is a positive regulator, whereas miR-200a is a negative regulator of insulin signaling in skeletal muscle, and both miRNAs have the potential to become therapeutic targets for preventing and treating insulin resistance or type 2 diabetes. +lncRNA target 32802182 hsa-mir-125a Osteoarthritis Methods: The function of CircCDK14 in OA, as well as the interaction between CircCDK14 and its downstream target (miR-125a-5p) and mRNA target (Smad2), was evaluated by western blot (WB), immunofluorescence (IF), RNA immunoprecipitation (RIP), quantitative RT-PCR, luciferase assay and fluorescence in situ hybridization (FISH). +exosome 32802175 hsa-mir-23b Multiple Sclerosis Further analysis of those EV-miRNAs demonstrated that miR-23b-3p played a predominant role in MS-SCs-EVs since its deprivation abolished their enhanced axonal elongation. +other 32802169 hsa-mir-21 Carcinoma, Non-Small-Cell Lung In conclusion, the expression of miRNA-21, PTEN and p271 in cancer tissue of NSCLC patients was low. +genetics_knock down_suppress 32801913 hsa-mir-765 Esophageal Squamous Cell Carcinoma CCK-8, transwell and glycolysis assays were used to investigate the effects of MAFG-AS1 on ESCC cell proliferation, migration, invasion and aerobic glycolysis after knockdown or overexpression of MAFG-AS1, and bioinformatics analyses, RNA pull-down and dual luciferase reporter systems were applied to investigate the interaction between MAFG-AS1, miR-765 and PDX1. +other 32801910 hsa-mir-10a Laryngeal Neoplasms Down-regulation of miR-10a-5p induced up-regulation of TrkB promoting development of laryngeal cancer. +genetics_knock down_promote 32801909 hsa-mir-1258 Carcinoma, Hepatocellular Overexpressed RPN2 could reverse the inhibiting effect of miR-1258 overexpression on HCC progression. +lncRNA target 32801908 hsa-mir-145 Carcinoma, Non-Small-Cell Lung HMGB3 was a direct downstream target of miR-145 in NSCLC cells. +genetics_overexpression_promote 32801906 hsa-mir-424 Carcinoma, Hepatocellular 5p up-regulation or down-regulation, together with overexpression or silencing of CDKN2B-AS1. +other 32801903 hsa-mir-137 Ovarian Neoplasms OIP5-AS1/miR-137/ZNF217 Axis Promotes Malignant Behaviors in Epithelial Ovarian Cancer. +target gene 32801901 hsa-mir-1 Prostatic Neoplasms miR-31-5p Regulates 14-3-3 ɛ to Inhibit Prostate Cancer 22RV1 Cell Survival and Proliferation via PI3K/AKT/Bcl-2 Signaling Pathway. +lncRNA target 32801893 hsa-mir-23a-2 Melanoma CONCLUSION: lncRNA MALAT1 promotes malignant proliferation of melanoma cells through miR-23a. +lncRNA target 32801893 hsa-mir-23 Melanoma CONCLUSION: lncRNA MALAT1 promotes malignant proliferation of melanoma cells through miR-23a. +lncRNA target 32801893 hsa-mir-23a Melanoma CONCLUSION: lncRNA MALAT1 promotes malignant proliferation of melanoma cells through miR-23a. +genetics_knock down_promote 32801889 hsa-mir-30 Glioma 3p promoted the proliferation, migration, and invasion of glioma cells, while LINC01094 knockdown or miR +genetics_knock down_promote 32801884 hsa-mir-1294 Osteosarcoma In addition, circ_0000885 knockdown reduced OS tumor growth via regulating the FGFR1 expression by sponging miR-1294 in vivo. +genetics_overexpression_promote 32801880 hsa-mir-498 Esophageal Squamous Cell Carcinoma Furthermore, VEGFA was verified as a direct target of miR-498 and reversed the effects of miR-498 overexpression on cell behaviors of ESCC in vitro. +lncRNA target 32801875 hsa-mir-143 Carcinoma, Hepatocellular 3p may target PSMG3AS1 to inhibit the proliferation of HCC cells. +genetics_knock down_promote 32801869 hsa-mir-27a Triple Negative Breast Neoplasms METHODS: QRT-PCR technique was used to detect the expression of miR-27a-3p in TNBC and normal breast cell lines or the effects of miR-27a-3p knockdown and overexpression in TNBC cell lines. +genetics_overexpression_promote 32801865 hsa-mir-145 Carcinoma, Hepatocellular In contrast, miR-145 overexpression improved the sensitivity of HCC cells to 5-FU and enhanced the inhibition of 5-FU on tumor growth. +other 32801863 hsa-mir-887 Pancreatic Neoplasms MiR-887-3p Negatively Regulates STARD13 and Promotes Pancreatic Cancer Progression. +lncRNA target 32801860 hsa-mir-146b Breast Neoplasms Mechanistic investigations revealed that miR-146b-5p was a direct target of lncRNA NEAT1, and its expression was correlated negatively with expression of lncRNA NEAT1 in BC tissues. +target gene 32801856 hsa-mir-3175 Lung Neoplasms LncRNA LINC00520 Predicts Poor Prognosis and Promotes Progression of Lung Cancer by Inhibiting MiR-3175 Expression. +circulation_biomarker_prognosis_up 32801784 hsa-mir-1290 Adenocarcinoma of Lung CONCLUSION: Serum exosomal miR-1290 could be a potential diagnostic and prognostic biomarker for LUAD. +genetics_knock down_promote 32801782 hsa-mir-375 Esophageal Squamous Cell Carcinoma HMGB1 could be targeted by miR-375/miR-433, and its overexpression also could invert the inhibition effect of circLPAR3 knockdown on ESCC progression. +genetics_knock down_promote 32801782 hsa-mir-433 Esophageal Squamous Cell Carcinoma HMGB1 could be targeted by miR-375/miR-433, and its overexpression also could invert the inhibition effect of circLPAR3 knockdown on ESCC progression. +other 32801780 hsa-mir-4458 gastric adenocarcinoma What's more, the clinical values of MIR4458HG and LINC01235 were also demonstrated in collected STAD samples. +genetics_overexpression_promote 32801777 hsa-mir-152 Stomach Neoplasms CONCLUSION: Our results demonstrated that HNF1A-induced HCG18 overexpression promoted GC progression by competitively binding with miR +target gene 32801774 hsa-mir-23b Colorectal Neoplasms lncRNA UCA1 Contributes to 5-Fluorouracil Resistance of Colorectal Cancer Cells Through miR-23b-3p/ZNF281 Axis. +lncRNA target 32801771 hsa-mir-1299 Carcinoma, Non-Small-Cell Lung CONCLUSION: We demonstrated that miR-1299 inhibits the progression of NSCLC through the EGFR/PI3K/Akt signal pathway. +target gene 32801770 hsa-mir-106b Glioblastoma miR-106b-5p Inhibits IRF1/IFN-β Signaling to Promote M2 Macrophage Polarization of Glioblastoma. +target gene 32801762 hsa-mir-183 Ovarian Neoplasms LEMD1-AS1 Suppresses Ovarian Cancer Progression Through Regulating miR-183-5p/TP53 Axis. +genetics_knock down_promote 32801754 hsa-mir-543 Uterine Cervical Neoplasms Intriguingly, rescue experiments revealed that miR-543 downregulation or TRPM7 overexpression abrogated the inhibitory actions of ST7-AS1 knockdown in the aggressive phenotype of cervical cancer cells. CONCLUSION: The newly identified ST7-AS1/miR-543/TRPM7 axis promoted the oncogenicity of cervical cancer cells both in vitro and in vivo. +other 32801751 hsa-mir-609 Carcinoma, Hepatocellular CONCLUSION: Therefore, the results indicate that miR-3609 decreases the expression of EPAS-1 and enhances the sensitivity of HCC cells to sorafenib. +genetics_knock down_suppress 32801746 hsa-mir-129 Lung Neoplasms Besides, knockdown of LINC00501 hindered the proliferation and invasion of NSCLC cells and intensified their apoptosis, and LINC00501 could be adopted as competitive endogenous RNA to regulate HMGB1 and tumorigenesis through miR +other 32801745 hsa-mir-409 Carcinoma, Non-Small-Cell Lung RESULTS: DUXAP8 was highly expressed in NSCLC, while miR3p was downregulated. +circulation_biomarker_diagnosis_up 32801339 hsa-mir-20 Cholangiocarcinoma The regulatory role of TTN-AS1 on miR-320a was further evaluated by luciferase reporter and RNA pulldown assays, coupled with in situ hybridization and RNA immunoprecipitation analyses, which showed that TTN-AS1 bound to miR-320a through an argonaute2-dependent RNA interference pathway in the cytoplasm of cholangiocarcinoma cells. +circulation_biomarker_diagnosis_up 32801339 hsa-mir-20a Cholangiocarcinoma The regulatory role of TTN-AS1 on miR-320a was further evaluated by luciferase reporter and RNA pulldown assays, coupled with in situ hybridization and RNA immunoprecipitation analyses, which showed that TTN-AS1 bound to miR-320a through an argonaute2-dependent RNA interference pathway in the cytoplasm of cholangiocarcinoma cells. +transcription factor target 32801294 hsa-mir-16 Diabetic Nephropathies Taken together, these findings highlight the potential of miR-16 as a promising therapeutic target for liver fibrosis. +circulation_biomarker_diagnosis_ns 32800995 hsa-mir-574 Epilepsy, Temporal Lobe 3p were also dysregulated in plasma from patients with intractable temporal lobe epilepsy. +circulation_biomarker_diagnosis_ns 32800995 hsa-mir-93 Epilepsy, Temporal Lobe 3p were also dysregulated in plasma from patients with intractable temporal lobe epilepsy. +circulation_biomarker_diagnosis_ns 32800995 hsa-mir-199a Epilepsy, Temporal Lobe 3p were also dysregulated in plasma from patients with intractable temporal lobe epilepsy. +genetics_overexpression_promote 32800940 hsa-mir-215 Melanoma Moreover, we confirmed that overexpression of circHIPK3 could facilitate cell proliferation and depress cell apoptosis in melanoma while overexpression of miR +circulation_biomarker_diagnosis_down 32800809 hsa-mir-223 Hyperlipidemias Paeonol (Pae) is a potential therapeutic drug for AS, and we have previously shown that Pae regulated the expression of monocytes-derived exosomal microRNA-223 (miR-223). Altogether, our results showed that Pae inhibited the downstream NLRP3 inflammasome pathway by increasing the level of miR-223 in plasma derived exosomes of hyperlipidemic rats, providing new insights in the treatment of AS with the use of Pae. +other 32800647 hsa-mir-663a Pancreatic Carcinoma Kaplan-Meier survival assessments of the top-ranked miRNAs revealed that three miRNAs, hsa-miR-1469, hsa-miR-663a and hsa-miR5p, had meaningful associations with the prognosis of patients with pancreatic cancer. +other 32800647 hsa-mir-1469 Pancreatic Carcinoma Kaplan-Meier survival assessments of the top-ranked miRNAs revealed that three miRNAs, hsa-miR-1469, hsa-miR-663a and hsa-miR5p, had meaningful associations with the prognosis of patients with pancreatic cancer. +other 32800647 hsa-mir-532 Pancreatic Carcinoma Kaplan-Meier survival assessments of the top-ranked miRNAs revealed that three miRNAs, hsa-miR-1469, hsa-miR-663a and hsa-miR5p, had meaningful associations with the prognosis of patients with pancreatic cancer. +genetics_overexpression_promote 32800545 hsa-mir-206 Colonic Neoplasms Mechanistically, miR-206 overexpression directly targeted hnRNPA1 to suppress PKM2 expression to attenuate Warburg effect and cell proliferation of CRC. +transcription factor target 32800335 hsa-mir-378a Intestinal Diseases MiR-378a-3p may serve as a promising biomarker and radioprotective target in abdominal cancer. +lncRNA target 32799891 hsa-mir-374a Colorectal Neoplasms CircTADA2A enhanced the abundance of KLF14 through targeting miR-374a-3p in CRC cells. +other 32799553 hsa-mir-619 Carcinoma, Hepatocellular Conclusion: On the whole, present study uncovered a novel ceRNA mechanism of GAS6-AS2/miR5p/ARL2 in HCC after insufficient RFA, which might shed a new insight into treatment of HCC after insufficient RFA. +other 32799333 hsa-mir-17 Sjogren's Syndrome RESULTS: In saliva, 14 miRNAs were significantly differentially expressed between pSS and non-pSS, including downregulation of the miR-17 family in pSS. +lncRNA target 32799221 hsa-mir-92a Colorectal Neoplasms 5p, and hsa-let-7i-5p), targeting the CT genes GAGE1, SSX2, PRAME, SCP1, and the gene for DNA methyltransferase 3A (DNMT3A), were found. +lncRNA target 32799221 hsa-mir-143 Colorectal Neoplasms 5p, and hsa-let-7i-5p), targeting the CT genes GAGE1, SSX2, PRAME, SCP1, and the gene for DNA methyltransferase 3A (DNMT3A), were found. +lncRNA target 32799221 hsa-mir-26a Colorectal Neoplasms 5p, and hsa-let-7i-5p), targeting the CT genes GAGE1, SSX2, PRAME, SCP1, and the gene for DNA methyltransferase 3A (DNMT3A), were found. +lncRNA target 32799221 hsa-mir-25 Colorectal Neoplasms 5p, and hsa-let-7i-5p), targeting the CT genes GAGE1, SSX2, PRAME, SCP1, and the gene for DNA methyltransferase 3A (DNMT3A), were found. +lncRNA target 32799221 hsa-let-7i Colorectal Neoplasms 5p, and hsa-let-7i-5p), targeting the CT genes GAGE1, SSX2, PRAME, SCP1, and the gene for DNA methyltransferase 3A (DNMT3A), were found. +lncRNA target 32799221 hsa-mir-21 Colorectal Neoplasms 5p, and hsa-let-7i-5p), targeting the CT genes GAGE1, SSX2, PRAME, SCP1, and the gene for DNA methyltransferase 3A (DNMT3A), were found. +circulation_biomarker_diagnosis_ns 32798803 hsa-mir-17 Multiple Sclerosis For example, an increase of the concentration of circulating miR-17 has been linked to lung cancer and metastatic breast cancer, while its decrease has been found in multiple sclerosis and gastric cancer. +circulation_biomarker_diagnosis_ns 32798803 hsa-mir-17 Lung Neoplasms For example, an increase of the concentration of circulating miR-17 has been linked to lung cancer and metastatic breast cancer, while its decrease has been found in multiple sclerosis and gastric cancer. +circulation_biomarker_diagnosis_ns 32798803 hsa-mir-17 hereditary diffuse gastric cancer For example, an increase of the concentration of circulating miR-17 has been linked to lung cancer and metastatic breast cancer, while its decrease has been found in multiple sclerosis and gastric cancer. +circulation_biomarker_diagnosis_ns 32798803 hsa-mir-17 Breast Neoplasms For example, an increase of the concentration of circulating miR-17 has been linked to lung cancer and metastatic breast cancer, while its decrease has been found in multiple sclerosis and gastric cancer. +circulation_biomarker_diagnosis_down 32798766 hsa-mir-199b Pre-Eclampsia We detected that PE serum downregulated the expression of miR-199a-5p, miR-199b-5p and miR-204, increased expression of CAV1 and increased cell monolayer permeability in HRGECs. DISCUSSION: miR-199b-5p and miR-204 may play a role in PES-induced increasing permeability of HRGECs by regulating CAV1 expression. +circulation_biomarker_diagnosis_down 32798766 hsa-mir-204 Pre-Eclampsia We detected that PE serum downregulated the expression of miR-199a-5p, miR-199b-5p and miR-204, increased expression of CAV1 and increased cell monolayer permeability in HRGECs. DISCUSSION: miR-199b-5p and miR-204 may play a role in PES-induced increasing permeability of HRGECs by regulating CAV1 expression. +other 32798621 hsa-mir-133 Coronary Artery Disease Patients with 3 coronary artery lesions had significantly higher myocardial expressions of miRNA-27a, miRNA-133, and miRNA-203 than patients with 1-2 vessel disease in the atrial myocardium (miRNA-27a: 234.62 29.51 vs. +other 32798621 hsa-mir-27a Coronary Artery Disease Patients with 3 coronary artery lesions had significantly higher myocardial expressions of miRNA-27a, miRNA-133, and miRNA-203 than patients with 1-2 vessel disease in the atrial myocardium (miRNA-27a: 234.62 29.51 vs. +circulation_biomarker_diagnosis_ns 32798621 hsa-mir-133a Coronary Artery Disease The right atrial and serum expressions of miRNA-27a, miRNA -133a, and miRNA-203 in 80 patients referred for elective coronary artery bypass graft surgery (CABG) and 20 control patients scheduled for heart valve surgery were analyzed using real-time polymerase chain reaction. +circulation_biomarker_diagnosis_ns 32798621 hsa-mir-203 Coronary Artery Disease The serum miRNA-203 expression level corresponds to myocardial expression and is strongly correlated with the extent of coronary atherosclerosis. +lncRNA target 32798559 hsa-mir-185 Diabetic Nephropathies CONCLUSION: Circ_WBSCR17 triggered the dysfunction of HG-induced HK-2 cells, including inflammatory responses and fibrosis, which was accomplished via the miR5p/SOX6 regulatory axis. +circulation_biomarker_prognosis_ns 32798423 hsa-mir-155 Thrombocytopenia OBJECTIVE To explore the value of has-microRNA-155 (miR-155) in peripheral blood mononuclear cells (PBMNC) in prognostic evaluation of elderly patients with primary immune thrombocytopenia (PITP). +genetics_overexpression_promote 32798408 hsa-mir-144 Multiple Myeloma Transwell cell invasion and migration assay was used to detect the invasion and migration ability of myeloma cells with overexpressing on miR-144.Western blot analysis was used to detect the protein expression levels of MMP-9 and MMP-2 in myeloma cells with over expression of miR-144, as well as the expression levels of proteins related to Wnt/beta-catenin signaling pathway. +other 32798394 hsa-mir-146a Leukemia, Myeloid, Acute CONCLUSION: MiR-146a is downregulated in AML patients, which might be served as a biomarker for predicting risk and prognosis of AML patients. +lncRNA target 32798383 hsa-mir-199a Leukemia, Myeloid, Acute DRAM1 is a functional target gene for miR-199a-5p modulating AML chemoresistance. +other 32798322 hsa-mir-15a Diabetes Mellitus, Type 1 Hsa_circ_0072697 may be involved in 50 circRNA-miRNA-mRNA signalling pathways related to diabetes, such as circ_0072697-miR-15a-UBASH3A network. +other 32798250 hsa-mir-34a Colorectal Neoplasms Clinically, high lncARSR and HK1 expression predicted poor survival of patients with CRC, especially when combined with low miR-34a-5p expression. Collectively, we identified lncARSR as an onco-lncRNA in CRC and demonstrated that the combination of lncARSR/miR-34a-5p/HK1 may be a potential prognostic biomarker of CRC. +other 32797932 hsa-mir-1246 Breast Neoplasms On the open-channel biological chip, sensitive, simultaneous, and specific detection of breast cancer marker miRNA-1246 can be performed. +lncRNA target 32797879 hsa-mir-223 Inflammatory Bowel Diseases Using miR-223, a potential biomarker of inflammatory bowel diseases (IBD), as the target miRNA, we devised the partially hybridized DNA/AgNC-cDNA fluorescent probe. This rapid, label-free, and low-cost fluorescence enhancing method can potentially be applied in the diagnosis of miR-223 associated disease, such as IBD. +transcription factor target 32797712 hsa-mir-128 Ischemic Stroke 3p significantly decreases MCAO-induced infraction volume and inhibited apoptotic response as revealed by decreased cleaved Caspase-3 protein expression in immunohistochemical analysis. +transcription factor target 32797712 hsa-mir-9 Ischemic Stroke 3p significantly decreases MCAO-induced infraction volume and inhibited apoptotic response as revealed by decreased cleaved Caspase-3 protein expression in immunohistochemical analysis. +genetics_knock down_promote 32797709 hsa-mir-134 Diabetic Retinopathy 5p knockdown. +lncRNA target 32797474 hsa-mir-16 Diabetes Mellitus, Type 1 5p implicated in T1DM cell proliferation and apoptosis through targeting CXCL10, which might provide novel therapeutic information for T1DM. +circulation_biomarker_diagnosis_up 32797181 hsa-mir-15b Diabetic Retinopathy RESULTS: We demonstrated that circulating miR-15b was directly associated with VEGF compared with other miRs in patients with PDR. +genetics_GWAS 32796834 hsa-mir-382 Fibrosis, Renal Renal abundance of miR-382 was upregulated following AA treatment, while genetic depletion or pharmacological inhibition of miR-382 partially reversed renal tubulointerstitial fibrosis. +genetics_GWAS 32796834 hsa-mir-382 Diabetic Nephropathies Renal abundance of miR-382 was upregulated following AA treatment, while genetic depletion or pharmacological inhibition of miR-382 partially reversed renal tubulointerstitial fibrosis. +transcription factor target 32796817 hsa-mir-93 Breast Neoplasms Taken together, our findings suggested that miR-93 greatly improved chemosensitivity and potentially served as a novel therapeutic target for breast cancer treatment. +lncRNA target 32796815 hsa-mir-519d Colorectal Neoplasms Further functional studies revealed that circMBOAT2 served as a microRNA (miRNA) sponge of miR-519d-3p and promoted the proliferation, migration, and invasion of CRC cells. Also, circMBOAT2 regulated cell proliferation and migration by competitively binding to miR-519d-3p and targeting troponin-associated protein (TROAP) in CRC cells. +other 32796618 hsa-mir-125 Pancoast Syndrome The combinatorial therapy of E and miR-125 nanoparticles effectively reduced SAS tumor growth. +lncRNA target 32795896 hsa-mir-16 Lupus Nephritis This research focused on the function of microRNA-16 (miR-16) in LN development. To sum up, miR-16 was evidenced to have a potent protective capacity in LN through relieving the LN symptoms in kidney tissues and reducing proliferation of mesangial cells, during which DEC2 silencing and TLR4 signaling deficit were involved. +lncRNA target 32795656 hsa-mir-376a Diabetic Nephropathies CAF+TRI+CGA reduced the hepatic protein levels of pro-proliferative EGFR (miR3p target), antiapoptotic Bcl-2 family members (miR-15b-5p targets), and the number of PCNA (miR-376a-3p target) positive hepatocytes in preneoplastic foci. +lncRNA target 32795656 hsa-mir-376a Carcinoma, Hepatocellular CAF+TRI+CGA reduced the hepatic protein levels of pro-proliferative EGFR (miR3p target), antiapoptotic Bcl-2 family members (miR-15b-5p targets), and the number of PCNA (miR-376a-3p target) positive hepatocytes in preneoplastic foci. +lncRNA target 32795656 hsa-mir-15b Diabetic Nephropathies CAF+TRI+CGA reduced the hepatic protein levels of pro-proliferative EGFR (miR3p target), antiapoptotic Bcl-2 family members (miR-15b-5p targets), and the number of PCNA (miR-376a-3p target) positive hepatocytes in preneoplastic foci. +lncRNA target 32795656 hsa-mir-15b Carcinoma, Hepatocellular CAF+TRI+CGA reduced the hepatic protein levels of pro-proliferative EGFR (miR3p target), antiapoptotic Bcl-2 family members (miR-15b-5p targets), and the number of PCNA (miR-376a-3p target) positive hepatocytes in preneoplastic foci. +lncRNA target 32795656 hsa-mir-144 Carcinoma, Hepatocellular CAF+TRI+CGA reduced the hepatic protein levels of pro-proliferative EGFR (miR3p target), antiapoptotic Bcl-2 family members (miR-15b-5p targets), and the number of PCNA (miR-376a-3p target) positive hepatocytes in preneoplastic foci. +lncRNA target 32795656 hsa-mir-144 Diabetic Nephropathies CAF+TRI+CGA reduced the hepatic protein levels of pro-proliferative EGFR (miR3p target), antiapoptotic Bcl-2 family members (miR-15b-5p targets), and the number of PCNA (miR-376a-3p target) positive hepatocytes in preneoplastic foci. +other 32795593 hsa-mir-200c Stomach Ulcer In conclusion, LncRNA H19 and related miRNAs, miRNA 200c/miRNA 139, could serve as a potential diagnostic biomarker for early gastric cancer diagnosis. +other 32795593 hsa-mir-200c Stomach Neoplasms In conclusion, LncRNA H19 and related miRNAs, miRNA 200c/miRNA 139, could serve as a potential diagnostic biomarker for early gastric cancer diagnosis. +other 32795593 hsa-mir-139 Stomach Neoplasms In conclusion, LncRNA H19 and related miRNAs, miRNA 200c/miRNA 139, could serve as a potential diagnostic biomarker for early gastric cancer diagnosis. +other 32795593 hsa-mir-139 Stomach Ulcer In conclusion, LncRNA H19 and related miRNAs, miRNA 200c/miRNA 139, could serve as a potential diagnostic biomarker for early gastric cancer diagnosis. +circulation_biomarker_diagnosis_up 32795559 hsa-mir-153 Diabetes Mellitus, Type 1 We investigated whether miR-153, an IL-1beta responsive miRNA, could mimic IL-1beta effects and whether its interruption would improve blood glucose control then offer an assistant curative approach to inflammation-associated diabetes. +other 32795526 hsa-mir-216b Retinoblastoma However, only 2 miRNAs - hsa-miR-301b-3p and hsa-miR-216b-5p were upregulated in the primary RB tissues. +lncRNA target 32795316 hsa-mir-139 Carcinoma, Hepatocellular ZFPM2-AS1 regulated the progression of HCC by acting as a competing endogenous RNA (ceRNA) to competitively bind to miR-139 and regulate GDF10 expression. Our study provides new insight into the posttranscriptional regulation mechanism of lncRNA ZFPM2-AS1 and suggests that ZFPM2-AS1/miR-139/GDF10 may act as a potential therapeutic target and prognostic biomarker for HCC. +lncRNA target 32795273 hsa-mir-4677 Adenocarcinoma of Lung CONCLUSIONS: LINC02418 contributes to the malignancy in LAD via miR3p/KNL1 signaling, providing a probable therapeutic direction for LAD. +genetics_overexpression_promote 32795216 hsa-mir-144 Nasopharyngeal Carcinoma In NPC cells, overexpression of IUR resulted in a downregulated expression of miR-144 and an upregulated expression of PTEN. +circRNA target 32794418 hsa-mir-21 Carcinoma, Non-Small-Cell Lung Further investigations revealed that miR-21 was the direct functional target of circ-SLC7A6, in which circ-SLC7A6 abundantly sponged miR-21 and elevated a cohort of tumor suppressors, thus inhibiting NSCLC progression. Overall, our study demonstrates that circ-SLC7A6 is a novel tumor suppressor in NSCLC, targeting circ-SLC7A6/miR-21 axis may be a promising treatment for NSCLC patients. +transcription factor target 32794340 hsa-mir-942 Uterine Cervical Neoplasms 5p suppressed the growth and invasion of CC cells, and growth factor-independent transcription repressor 1 (GFI1) gene was the target gene of miR +other 32793975 hsa-mir-146a Inflammatory Bowel Diseases CONCLUSIONS: Five candidate miRNAs associated with clinical response and mucosal inflammation in pediatric IBD patients were identified (miR-126, let-7c, miR-146a, miR-146b, and miR-320a). +other 32793975 hsa-mir-126 Inflammatory Bowel Diseases CONCLUSIONS: Five candidate miRNAs associated with clinical response and mucosal inflammation in pediatric IBD patients were identified (miR-126, let-7c, miR-146a, miR-146b, and miR-320a). +other 32793975 hsa-mir-20a Inflammatory Bowel Diseases CONCLUSIONS: Five candidate miRNAs associated with clinical response and mucosal inflammation in pediatric IBD patients were identified (miR-126, let-7c, miR-146a, miR-146b, and miR-320a). +other 32793975 hsa-mir-146b Inflammatory Bowel Diseases CONCLUSIONS: Five candidate miRNAs associated with clinical response and mucosal inflammation in pediatric IBD patients were identified (miR-126, let-7c, miR-146a, miR-146b, and miR-320a). +other 32793975 hsa-let-7c Inflammatory Bowel Diseases CONCLUSIONS: Five candidate miRNAs associated with clinical response and mucosal inflammation in pediatric IBD patients were identified (miR-126, let-7c, miR-146a, miR-146b, and miR-320a). +other 32793730 hsa-mir-483 Medulloblastoma CONCLUSIONS: Our study altogether demonstrated HOTAIR influence cell proliferation and apoptosis by regulation of miR3p and CDK4 in medulloblastoma cells. +lncRNA target 32793720 hsa-mir-6867 Ischemic Stroke CONCLUSIONS: In this study, we found that LncRNA MACC1-AS1 exerted a protective role in hypoxia-induced HBMECs via regulating miR5p/TWIST1, indicating a new therapeutic strategy for future ischemic stroke therapy. +genetics_overexpression_promote 32793634 hsa-let-7i ankylosing spondylitis 1 Additionally, let-7i could target SOST, and SOST silencing reversed the inhibitory effect of let-7i inhibitor or MEG3 overexpression on the inflammation and bone formation of AS. +circRNA target 32793474 hsa-mir-873 Neuroblastoma In conclusion, our work proved that circDGKB promoted NB progression via targeting miR-873/GLI1 axis in vitro and in vivo. +circulation_biomarker_diagnosis_up 32793278 hsa-mir-21 Carcinoma, Hepatocellular CONCLUSION: Together with serum AFP, plasma exosomal miR +circulation_biomarker_diagnosis_up 32793278 hsa-mir-92 Carcinoma, Hepatocellular CONCLUSION: Together with serum AFP, plasma exosomal miR +circulation_biomarker_diagnosis_up 32793278 hsa-mir-92a Carcinoma, Hepatocellular CONCLUSION: Together with serum AFP, plasma exosomal miR +exosome 32792909 hsa-mir-146b Ischemic Stroke In addition, EA also could improve neurological deficits through miR-146b after ischemic stroke. Conclusion: EA promotes the differentiation of endogenous neural stem cells via exosomal miR-146b to improve neurological injury after ischemic stroke. +circRNA target 32792505 hsa-mir-28 Intervertebral Disc Degeneration Our previous study confirmed that the downregulated circ-GRB10 directly interacts with miR5p, which modulate ERBB2 and leads to the degeneration of intervertebral disc; however, the underpinning mechanism of circ-GRB10 dysregulation remains unclear. +circRNA target 32792057 hsa-mir-144 Pneumonia, Mycoplasma MiR-144 was down-regulated in PE placental tissues, and restoration of miR-144 induced proliferation, invasion, and migration in trophoblast cells. CONCLUSION: Circ_0085296 inhibited trophoblast cell proliferation, invasion, and migration via regulating miR-144/E-cadherin axis, providing a novel insight into the pathogenesis of PE and a new prospective therapeutic target for PE patients. +other 32791990 hsa-mir-194 Neurotoxicity Syndromes In addition, we provided new evidence that the lincRNA PADNA/miR-194/FBXW7 axis plays an important role in the neurotoxicity process. +other 32791870 hsa-mir-23b Muscular Dystrophy, Duchenne Furthermore, the five TFs ZNF362, ATAT1, SPI1, TCF12 and ABCF2, as well as the eight miRNAs miR-124a, miR-200b/200c/429, miR-19a/b, miR-23a/b, miR-182, miR-144, miR-498 and miR-18a/b were identified as playing crucial roles in the molecular pathogenesis of DMD. +other 32791870 hsa-mir-19b Muscular Dystrophy, Duchenne Furthermore, the five TFs ZNF362, ATAT1, SPI1, TCF12 and ABCF2, as well as the eight miRNAs miR-124a, miR-200b/200c/429, miR-19a/b, miR-23a/b, miR-182, miR-144, miR-498 and miR-18a/b were identified as playing crucial roles in the molecular pathogenesis of DMD. +other 32791870 hsa-mir-23a Muscular Dystrophy, Duchenne Furthermore, the five TFs ZNF362, ATAT1, SPI1, TCF12 and ABCF2, as well as the eight miRNAs miR-124a, miR-200b/200c/429, miR-19a/b, miR-23a/b, miR-182, miR-144, miR-498 and miR-18a/b were identified as playing crucial roles in the molecular pathogenesis of DMD. +other 32791870 hsa-mir-18a Muscular Dystrophy, Duchenne Furthermore, the five TFs ZNF362, ATAT1, SPI1, TCF12 and ABCF2, as well as the eight miRNAs miR-124a, miR-200b/200c/429, miR-19a/b, miR-23a/b, miR-182, miR-144, miR-498 and miR-18a/b were identified as playing crucial roles in the molecular pathogenesis of DMD. +other 32791870 hsa-mir-19a Muscular Dystrophy, Duchenne Furthermore, the five TFs ZNF362, ATAT1, SPI1, TCF12 and ABCF2, as well as the eight miRNAs miR-124a, miR-200b/200c/429, miR-19a/b, miR-23a/b, miR-182, miR-144, miR-498 and miR-18a/b were identified as playing crucial roles in the molecular pathogenesis of DMD. +other 32791870 hsa-mir-200c Muscular Dystrophy, Duchenne Furthermore, the five TFs ZNF362, ATAT1, SPI1, TCF12 and ABCF2, as well as the eight miRNAs miR-124a, miR-200b/200c/429, miR-19a/b, miR-23a/b, miR-182, miR-144, miR-498 and miR-18a/b were identified as playing crucial roles in the molecular pathogenesis of DMD. +other 32791870 hsa-mir-144 Muscular Dystrophy, Duchenne Furthermore, the five TFs ZNF362, ATAT1, SPI1, TCF12 and ABCF2, as well as the eight miRNAs miR-124a, miR-200b/200c/429, miR-19a/b, miR-23a/b, miR-182, miR-144, miR-498 and miR-18a/b were identified as playing crucial roles in the molecular pathogenesis of DMD. +other 32791870 hsa-mir-200b Muscular Dystrophy, Duchenne Furthermore, the five TFs ZNF362, ATAT1, SPI1, TCF12 and ABCF2, as well as the eight miRNAs miR-124a, miR-200b/200c/429, miR-19a/b, miR-23a/b, miR-182, miR-144, miR-498 and miR-18a/b were identified as playing crucial roles in the molecular pathogenesis of DMD. +other 32791870 hsa-mir-498 Muscular Dystrophy, Duchenne Furthermore, the five TFs ZNF362, ATAT1, SPI1, TCF12 and ABCF2, as well as the eight miRNAs miR-124a, miR-200b/200c/429, miR-19a/b, miR-23a/b, miR-182, miR-144, miR-498 and miR-18a/b were identified as playing crucial roles in the molecular pathogenesis of DMD. +other 32791870 hsa-mir-124a Muscular Dystrophy, Duchenne Furthermore, the five TFs ZNF362, ATAT1, SPI1, TCF12 and ABCF2, as well as the eight miRNAs miR-124a, miR-200b/200c/429, miR-19a/b, miR-23a/b, miR-182, miR-144, miR-498 and miR-18a/b were identified as playing crucial roles in the molecular pathogenesis of DMD. +other 32791870 hsa-mir-182 Muscular Dystrophy, Duchenne Furthermore, the five TFs ZNF362, ATAT1, SPI1, TCF12 and ABCF2, as well as the eight miRNAs miR-124a, miR-200b/200c/429, miR-19a/b, miR-23a/b, miR-182, miR-144, miR-498 and miR-18a/b were identified as playing crucial roles in the molecular pathogenesis of DMD. +circulation_biomarker_diagnosis_up 32791453 hsa-mir-194 Osteoporosis 5p level in plasma is inversely related to the degree of bone formation in osteoporosis patients. +other 32791450 hsa-mir-1299 Ovarian Neoplasms Circular RNA circTNPO3 Regulates Paclitaxel Resistance of Ovarian Cancer Cells by miR-1299/NEK2 Signaling Pathway. +genetics_overexpression_suppress 32791096 hsa-mir-1271 Glioblastoma Overexpressing miR-1271 inhibited GBM cell proliferation and invasion, whereas inhibiting miR-1271 increased cell proliferation and invasion. +other 32791063 hsa-mir-21 Fibrosis, Renal CONCLUSION: Activation of lncRNA-GAS5 attenuates kidney fibrosis by modulating miR-21 activity and may serve as a surrogate biomarker in monitoring CKD progression. +lncRNA target 32790946 hsa-mir-149 Osteoarthritis Our data reveal that resistin enhances the expression of TNF-alpha and IL-1beta in OASFs by inhibiting miR-149 expression via MEK and ERK signaling. +other 32790532 hsa-mir-122 Hepatitis C CONCLUSION: This meta-analysis demonstrates that miR-122 may be a useful diagnostic biomarker for HCV-associated HCC. +other 32790532 hsa-mir-122 Carcinoma, Hepatocellular CONCLUSION: This meta-analysis demonstrates that miR-122 may be a useful diagnostic biomarker for HCV-associated HCC. +other 32790341 hsa-let-7a Acute Kidney Injury Further analysis revealed that the presence of microRNA let-7a-5p in MSC-EVs served as the mechanism contributing to the reduced cell apoptosis and elevated cell autophagy in AKI. In conclusion, RGD hydrogels facilitated MSC-derived let-7a-5p-containing EVs, improving reparative potential against AKI. +lncRNA target 32790250 hsa-mir-29b Cholangiocarcinoma CONCLUSIONS: The DHA and miR-29b have a pro-apoptotic effect on cholangiocarcinoma cells through the DHA/miR-29b/Mcl-1 pathway, possibly by upregulating the expression of the pro-apoptotic protein Mcl-1S and thus increasing the proportion of Mcl-1S protein among the total amount of Mcl-1 protein. +genetics_overexpression_promote 32790238 hsa-mir-130a Ischemic Stroke MiR-130a was overexpressed while XIAP was down-regulated in MCAO rats and OGD-treated neurons. +circRNA target 32789658 hsa-mir-1184 Urinary Bladder Neoplasms From the potential mechanism analysis, our data suggested that circBC048201 and miR-1184, miR-1184 and ITGA3 could bind to each other, and the interference with circBC048201 repressed bladder cancer cell proliferation, migration, and invasion through the miR-1184/ITGA3 axis. In summary, our results showed that circBC048201 was abnormally highly expressed in bladder cancer tissues and cells, and the interference with circBC048201 inhibited the proliferation, migration, and invasion of bladder cancer cells through the miR-1184/ITGA3 axis. +transcription factor target 32788878 hsa-mir-145 Thyroid Cancer, Papillary MiR-145 inhibited PTC migration, proliferation and promoted apoptosis by directly suppresing RAB5C. +transcription factor target 32788584 hsa-mir-98 Neuroblastoma The data collectively demonstrated that RNA m(6)A modification was required for miR-98/MYCN axis-mediated inhibition of neuroblastoma progression, and miR-98 might be novel targets for NB detection and treatment. +other 32788048 hsa-mir-203 Leukemia, Lymphocytic, Chronic, B-Cell The SUM159 cell line is derived from human CLBC tissue; the GSE50697 dataset contains three replicates of SUM159 cells treated with pBabe puro miR-203 and three replicates of control SUM159 cells (pBabe puro). +other 32787969 hsa-mir-150 Thrombosis The goal of this study was to investigate the influence of miR-150 on the behavior of EPCs and its potential contribution in venous thrombosis resolution. Our findings also showed that miR-150 led to the enhanced resolution ability of EPCs in a rat venous thrombosis model. +transcription factor target 32787945 hsa-mir-1 Reperfusion Injury Specific miRNAs, such as novel_miR-17 and rno-miR-429 are probably new potential targets for further functional studies of hypothermic ischemia-RA. +transcription factor target 32787945 hsa-mir-17 Reperfusion Injury Specific miRNAs, such as novel_miR-17 and rno-miR-429 are probably new potential targets for further functional studies of hypothermic ischemia-RA. +exosome 32787917 hsa-mir-221 Diabetes Mellitus CONCLUSIONS: Exosomes originated from ATV-pretreated MSCs might serve as a potential strategy for the treatment of diabetic skin defects through enhancing the biological function of endothelial cells via AKT/eNOS pathway by upregulating the miR3p. +lncRNA target 32787827 hsa-mir-433 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: PCGEM1 accelerates NSCLC progression via sponging miR +lncRNA target 32787801 hsa-mir-448 Squamous Cell Carcinoma of Head and Neck Evidence indicates that miR-448 promotes the proliferation and inhibits apoptosis of OSCC cells. +other 32787581 hsa-mir-1297 Carcinoma, Hepatocellular Further experiments demonstrated that circ_101141 contributed to the progression of HCC by acting as competing endogenous RNA (ceRNA) of miR-1297 to regulate ROCK1 expression. Taken together, these findings indicated that circRNA circ_101141 acted as a ceRNA to facilitate tumorigenesis of HCC by regulating miR-1297/ROCK1 pathway. +circulation_biomarker_diagnosis_up 32787544 hsa-mir-125b Pre-Eclampsia The miR-125b level in the serum of PE patients was up-regulated as compared with normal pregnant women, and high level of miR-125b reduced cell proliferation, inhibited invasion and migration of HTR-8/SVneo as well as the expressions of STAT3, p-STAT3 and SOCS3, while low level of miR-125b produced the opposite results. +other 32787491 hsa-mir-126 Immune System Diseases Bone marrow-derived mesenchymal stem cells (BMSCs) are widely used for the treatment of inflammatory and immune diseases, and microRNA-126 (miR-126) is a critical regulator in inflammation as well as immunity. +lncRNA target 32787433 hsa-mir-1 Squamous Cell Carcinoma of Head and Neck To conclude, CASC2 boosted the DDP sensitivity and apoptosis of DDP-resistant OSCC cells by upregulating KANK1 via sponging miR +lncRNA target 32787143 hsa-mir-15b Alzheimer Disease Herein, we report a novel strategy in the design of multitargeted therapeutics for AD through dual inhibition of acetylcholinesterase (AChE) and microRNA-15b biogenesis. We performed high-throughput screening (HTS) of a chemical library to identify binders of mircoRNA-15b which is identified as a biomarker and potential therapeutic target of AD. +circulation_biomarker_diagnosis_ns 32786465 hsa-mir-21 Breast Neoplasms Importantly, the assay of microRNA-21 was successfully achieved using this sensor in human serum samples and human breast cancer cell (MCF-7) lysates. +lncRNA target 32786108 hsa-mir-10a Carcinoma, Hepatocellular Our results unraveled LEF1-AS1 acts as a miR-10a-5p modulator to promote chemoresistance of HCC cells by stimulating MSI1 and activating the AKT signaling pathway, which might provide a novel therapeutic target for HCC. +other 32786095 hsa-mir-19a Muscular Dystrophy, Duchenne In parallel network analyses, we discovered a subnetwork associated with BMD and BB use containing two of these nine miRNAs, miR-19a-3p and miR5p. +circulation_biomarker_diagnosis_ns 32785981 hsa-mir-125a Respiratory Distress Syndrome METHODS: LncRNA NEAT1 and miR-125a in plasma samples from 102 sepsis patients and 100 healthy controls (HCs) were detected by reverse transcription-quantitative polymerase chain reaction. +circulation_biomarker_diagnosis_ns 32785981 hsa-mir-125a Sepsis METHODS: LncRNA NEAT1 and miR-125a in plasma samples from 102 sepsis patients and 100 healthy controls (HCs) were detected by reverse transcription-quantitative polymerase chain reaction. +genetics_overexpression_suppress 32785967 hsa-mir-148a Stomach Neoplasms Overexpression of miR-148a-3p could inhibit the proliferative phenotype, metastatic phenotype, and cancer stem-like properties of gastric cancer cells. +other 32785889 hsa-mir-27a Porcine Reproductive and Respiratory Syndrome Further experiments proved that miR3p and miR-27a-5p can promote PRRSV replication significantly. +other 32785889 hsa-mir-21 Porcine Reproductive and Respiratory Syndrome Further experiments proved that miR3p and miR-27a-5p can promote PRRSV replication significantly. +other 32785863 hsa-mir-16 Brain Injuries, Traumatic 5p within 24 h and these microRNAs can be successfully used as TBI-specific biomarkers. +other 32785863 hsa-mir-21 Brain Injuries, Traumatic 5p within 24 h and these microRNAs can be successfully used as TBI-specific biomarkers. +other 32785863 hsa-mir-155 Brain Injuries, Traumatic 5p within 24 h and these microRNAs can be successfully used as TBI-specific biomarkers. +other 32785863 hsa-mir-9 Brain Injuries, Traumatic 5p within 24 h and these microRNAs can be successfully used as TBI-specific biomarkers. +other 32785863 hsa-mir-34a Brain Injuries, Traumatic 5p within 24 h and these microRNAs can be successfully used as TBI-specific biomarkers. +circulation_biomarker_diagnosis_ns 32785072 hsa-mir-145 Malformations of Cortical Development Based on the integrated platform of HMDD v3.2, miRway DB and DIANA-miRPath v3.0 online tools, and confirmed by MiRBase analysis, four potentially predicted miRNAs from serum exosomes in patients with FCD were identified, including miR194 +circulation_biomarker_diagnosis_ns 32785072 hsa-mir-132 Malformations of Cortical Development Based on the integrated platform of HMDD v3.2, miRway DB and DIANA-miRPath v3.0 online tools, and confirmed by MiRBase analysis, four potentially predicted miRNAs from serum exosomes in patients with FCD were identified, including miR194 +circulation_biomarker_diagnosis_ns 32785072 hsa-mir-194-2 Malformations of Cortical Development Based on the integrated platform of HMDD v3.2, miRway DB and DIANA-miRPath v3.0 online tools, and confirmed by MiRBase analysis, four potentially predicted miRNAs from serum exosomes in patients with FCD were identified, including miR194 +circulation_biomarker_diagnosis_ns 32785072 hsa-mir-15a Malformations of Cortical Development Based on the integrated platform of HMDD v3.2, miRway DB and DIANA-miRPath v3.0 online tools, and confirmed by MiRBase analysis, four potentially predicted miRNAs from serum exosomes in patients with FCD were identified, including miR194 +other 32784833 hsa-mir-16 Prostatic Neoplasms Receiver operating characteristic (ROC) curve analyses revealed a potential for non-invasive urine-based PCa detection for miR-16 (AUC = 0.744, p = 0.012; accuracy = 76%) and miR-195 (AUC = 0.729, p = 0.017; accuracy = 70%). +other 32784833 hsa-mir-195 Prostatic Neoplasms Receiver operating characteristic (ROC) curve analyses revealed a potential for non-invasive urine-based PCa detection for miR-16 (AUC = 0.744, p = 0.012; accuracy = 76%) and miR-195 (AUC = 0.729, p = 0.017; accuracy = 70%). +circulation_biomarker_diagnosis_ns 32784653 hsa-mir-375 Prostatic Neoplasms The present study clearly demonstrates that miR-93 and miR-375 could be taken into consideration as single blood-based non-invasive molecules to distinguish PCa from BPH patients. +circulation_biomarker_diagnosis_ns 32784653 hsa-mir-93 Prostatic Neoplasms The present study clearly demonstrates that miR-93 and miR-375 could be taken into consideration as single blood-based non-invasive molecules to distinguish PCa from BPH patients. +transcription factor target 32784600 hsa-mir-489 Triple Negative Breast Neoplasms To define the mechanism by which miR-489 inhibits TNBC cell functions, we screened the potential target genes of miR-489 and identified MDC-1 and SUZ-12 as novel target genes of miR-489 in TNBC cells. +lncRNA target 32784466 hsa-mir-218 Glioma 5p signaling circuit is a potential clinical biomarker or therapeutic target for GB. +other 32784455 hsa-mir-222 Melanoma MicroRNA-222 Regulates Melanoma Plasticity. +genetics_knock down_suppress 32784268 hsa-mir-493 Carcinoma, Non-Small-Cell Lung 5p/ITGB1 axis could neutralize the regulatory impact of NR2F1-AS1 knockdown on the malignant phenotype of NSCLC cells. +lncRNA target 32784058 hsa-mir-424 Breast Neoplasms 5p could be considered as a potential tumor-suppressor miR in regulating BC cellular growth, apoptosis, and T cell-related immune response through targeting PD-L1, and its downstream mediators. +other 32783891 hsa-mir-101 Cardiovascular Diseases Overall, our results suggest that CdCl(2)-induced abnormal angiogenesis is mediated by miR-101/COX-2/VEGF-axis-dependent ER stress, and that cardiovascular dysfunction may be controlled by manipulating COX-2 at the pre-transcription, transcription, and post-transcription levels. +other 32783891 hsa-mir-101 Stress Disorders, Traumatic, Acute The use of mimic miR-101 (mi101) to induce the expression of miR-101 eventually leads to reduced COX-2 protein levels, relieved ER stress, and less abnormal angiogenesis and cytotoxicity of CdCl(2)-exposed primary HUVECs. Overall, our results suggest that CdCl(2)-induced abnormal angiogenesis is mediated by miR-101/COX-2/VEGF-axis-dependent ER stress, and that cardiovascular dysfunction may be controlled by manipulating COX-2 at the pre-transcription, transcription, and post-transcription levels. +genetics_overexpression_promote 32783743 hsa-mir-23a Glioblastoma In GBM cells, overexpression of TPT1-AS1 did not affect the expression of miR-23a-5p, but upregulated ECM1. +genetics_overexpression_promote 32783691 hsa-mir-638 Carcinoma, Non-Small-Cell Lung Besides, miR-638 targeted FAM83F and FAM83F overexpression abolished miR-638 enhancement-mediated proliferation, migration, invasion, and glycolysis of NSCLC cells. +other 32783497 hsa-mir-885 Carcinoma, Renal Cell 5p/ PLIN3 pathway may serve as a potential therapeutic strategy and a biomarker for sunitinib treatment in ccRCC. +lncRNA target 32783402 hsa-mir-615 Ovarian Neoplasms In summary, lncRNA HOTTIP promotes the growth and metastatic phenotypes of ovarian cancer via regulating miR +transcription factor target 32783381 hsa-mir-34a Leukemia, Promyelocytic, Acute Chidamide exerts its anticancer effect via the HDAC-mediated miR-34a/Bcl-2 axis, providing potential targets for APL therapy. +other 32783282 hsa-mir-203 Myocardial Reperfusion Injury Ischaemia-reperfusion rats were treated with SEV, miR-203 antagomir or sh-DCX, followed by determination of oxidative stress- and inflammation-related factor levels using nitrite and enzyme-linked immunosorbent assays, and that of apoptosis-related factors using Western blot analysis. +lncRNA target 32782715 hsa-mir-9 Endometriosis 5p can promote the invasion and migration of endometrial stromal cells in vitro by targeting the SIRT1 expression via the NF-kappaB pathway. +lncRNA target 32782712 hsa-mir-21 Intracranial Aneurysm CONCLUSION: MiR-21 can promote the production of inflammation-related factors through the JNK signaling pathway, leading to the formation and rupture of an intracranial aneurysm. +genetics_knock down_promote 32782707 hsa-mir-605 Melanoma CONCLUSION: Knockdown of circ_0016418 suppressed melanoma development and glutamine catabolism by modulating the miR +circulation_biomarker_prognosis_ns 32782678 hsa-mir-1246 Carcinoma, Non-Small-Cell Lung In conclusion, serum exosomal miR-1246 might be a useful diagnostic and prognostic biomarker for NSCLC. +target gene 32782670 hsa-mir-194 Carcinoma, Hepatocellular MiR-194 promotes hepatocellular carcinoma through negative regulation of CADM1. +genetics_overexpression_promote 32782620 hsa-mir-21 Glioma Furthermore, SOX7 was predicted as the potential target of miR-21, and its expression was upregulated in glioma cells by overexpression of NBAT1 compared with the vehicle only control. +target gene 32782619 hsa-mir-574 Liver Neoplasms MicroRNA-574-3p inhibits the malignant behavior of liver cancer cells by targeting ADAM28. +genetics_overexpression_promote 32782613 hsa-mir-221 Carcinoma, Non-Small-Cell Lung In NSCLC cells, ZNF281 overexpression resulted in upregulated PTEN and downregulated miR-221 expression, whereas cells with miR-221 overexpression exhibited downregulated PTEN expression and unaffected ZNF281 expression. Therefore, ZNF281 may upregulate PTEN via downregulation of miR-221 in NSCLC, resulting in inhibition of cancer cell proliferation and the promotion of apoptosis. +other 32782612 hsa-mir-215 Colorectal Neoplasms 5p could be used as prognostic indicators for patients with colorectal cancer. +other 32782612 hsa-mir-452 Colorectal Neoplasms 5p could be used as prognostic indicators for patients with colorectal cancer. +genetics_overexpression_promote 32782598 hsa-mir-125b Thyroid Cancer, Papillary GLUT1 overexpression promoted the proliferation of PTC cells and reduced the effects of miR-125b overexpression on cancer cell proliferation. +circulation_biomarker_diagnosis_ns 32782594 hsa-mir-433 Breast Neoplasms 5p and miR-433 in peripheral blood of breast cancer patients is lower than that of healthy people, and the expression level is closely related to clinical stages and differentiation degree, which is expected to provide reference value for judging the state of breast cancer patients. +target gene 32782592 hsa-mir-502 Stomach Neoplasms miR-502-5p inhibits the proliferation, migration and invasion of gastric cancer cells by targeting SP1. +exosome 32782588 hsa-mir-34b Ovarian Neoplasms Exosomal miR-34b inhibits proliferation and the epithelial-mesenchymal transition by targeting Notch2 in ovarian cancer. +other 32782579 hsa-let-7 Carcinoma, Pancreatic Ductal Downregulation of the let-7 family may help promote the INSR/IGF pathway in PDAC. +circulation_biomarker_prognosis_ns 32782563 hsa-mir-378e Colorectal Neoplasms Expression levels of LI-cadherin and miR-378e in the serum of patients with colorectal cancer, and the diagnostic value and prognostic significance in colorectal cancer were investigated. +transcription factor target 32782562 hsa-mir-429 Osteosarcoma More importantly, rescue assays manifested that HOXA9 can partially overturn the suppressive effect of miR-429 on OS. +other 32782558 hsa-mir-126 Colorectal Neoplasms Taken together, the results of the present study suggest that miR-126 downregulation may be a candidate molecular marker predictive of poor prognosis of patients with CRC. +other 32782548 hsa-mir-363 Aspergillosis 3p and -30e-5p were significantly downregulated miRNAs (P<0.05) with a >2-fold difference between the ASM and ASP groups compared with HCs. +other 32782548 hsa-mir-23a Aspergillosis 3p and -30e-5p were significantly downregulated miRNAs (P<0.05) with a >2-fold difference between the ASM and ASP groups compared with HCs. +other 32782548 hsa-mir-363 spondyloepimetaphyseal dysplasia, Strudwick type 3p and -30e-5p were significantly downregulated miRNAs (P<0.05) with a >2-fold difference between the ASM and ASP groups compared with HCs. +other 32782548 hsa-let-7e spondyloepimetaphyseal dysplasia, Strudwick type 3p and -30e-5p were significantly downregulated miRNAs (P<0.05) with a >2-fold difference between the ASM and ASP groups compared with HCs. +other 32782548 hsa-mir-28 Aspergillosis 3p and -30e-5p were significantly downregulated miRNAs (P<0.05) with a >2-fold difference between the ASM and ASP groups compared with HCs. +other 32782548 hsa-mir-28 spondyloepimetaphyseal dysplasia, Strudwick type 3p and -30e-5p were significantly downregulated miRNAs (P<0.05) with a >2-fold difference between the ASM and ASP groups compared with HCs. +other 32782548 hsa-mir-23a spondyloepimetaphyseal dysplasia, Strudwick type 3p and -30e-5p were significantly downregulated miRNAs (P<0.05) with a >2-fold difference between the ASM and ASP groups compared with HCs. +other 32782548 hsa-let-7e Aspergillosis 3p and -30e-5p were significantly downregulated miRNAs (P<0.05) with a >2-fold difference between the ASM and ASP groups compared with HCs. +other 32782541 hsa-mir-129-1 Carcinoma, Non-Small-Cell Lung In summary, the current study demonstrated hypoxia-dependent miR1-3p-mediated regulation of PPM1D protein expression in NSCLC cell line harboring mutant TP53. +genetics_overexpression_promote 32782539 hsa-mir-101 Colorectal Neoplasms Furthermore, the overexpression of Rap1b promoted miR-101 mimic-attenuated CRC cell progression. +genetics_knock down_promote 32782509 hsa-mir-138 Keloid Taken together, the results of the present study demonstrated that circ_101238 was upregulated in keloid tissues in comparison with normal tissues and that circ_101238 knockdown inhibited cell proliferation, while promoting apoptosis of keloid fibroblasts via the miR +target gene 32782498 hsa-mir-411 Ovarian Neoplasms hsa-microRNA-411-5p regulates proliferation, migration and invasion by targeting the hyaluronan mediated motility receptor in ovarian cancer. +circulation_biomarker_diagnosis_ns 32782496 hsa-mir-646 Pre-Eclampsia In the current study, human peripheral blood-derived endothelial progenitor cells (EPCs) were isolated to study the coordination between miR-646, vascular endothelial growth factor (VEGF)-A and hypoxia-inducible factor (HIF)-1alpha expression in preeclampsia EPCs. +circulation_biomarker_diagnosis_up 32782495 hsa-mir-21 Pre-Eclampsia The present study demonstrated that the expression of FOXM1 mRNA and protein is downregulated, whereas the expression of miR-21 is upregulated in the placenta and blood samples of PE patients. +lncRNA target 32782494 hsa-mir-33a Fluoride Poisoning ox-LDL successfully induced the foam cell model, promoted phosphorylation of IkappaBalpha, promoted nuclear translocation of NF-kappaB, promoted the expression of TLR4 and miR33a, and promoted the secretion of TNF-alpha, MCP-1 and Il-6. Curcumin promoted cholesterol efflux by suppressing the TLR4/NF-kappaB/miR33a signaling pathway, and reduced the formation of foam cells and the secretion of inflammatory factors. +circRNA target 32782441 hsa-mir-338 Multiple Myeloma CONCLUSION: Circ_0007841 acted as an oncogene to promote the proliferation, cell cycle and motility and restrain the apoptosis of MM cells through sequestering miR +other 32782439 hsa-mir-186 Prostatic Neoplasms Long non-coding RNA SNHG6 regulates the sensitivity of prostate cancer cells to paclitaxel by sponging miR-186. +target gene 32782437 hsa-mir-497 Leukemia, Myeloid, Acute Tanshinone IIA regulates human AML cell proliferation, cell cycle, and apoptosis through miR-497-5p/AKT3 axis. +epigenetics 32782436 hsa-mir-24 Breast Neoplasms Moreover, two potential mechanisms responsible for GPX3 downregulation in breast cancer, including hypermethylation of GPX3 promoter and release of hsa-miR5p inhibition. +other 32782283 hsa-mir-669m Hematologic Diseases In conclusion, using miR-669m, we found Akap7 and Xk, which may be involved in erythroid differentiation, implying that manipulating these genes could be a therapeutic way for diseases associated with erythropoiesis dysfunction. +lncRNA target 32782238 hsa-mir-1180 Adenocarcinoma of Lung CONCLUSIONS Upregulating circ_0008193 inhibited LUAD cell proliferation, migration, invasion, and Warburg effect under hypoxia in vitro and in vivo through regulation of the miR +lncRNA target 32782028 hsa-mir-27b Ovarian Neoplasms CONCLUSION: This research revealed that miR-27b-5p restrained the progression of ovarian carcinoma possibly via targeting CXCL1. +lncRNA target 32781986 hsa-mir-935 Prostatic Neoplasms Mechanically, LINC00992 interacted with and negatively regulated miR-3935 to elevate GOLM1 expression in prostate cancer cells. CONCLUSIONS: LINC00992 competitively bound with miR-3935 to elevate GOLM1 expression and therefore facilitate the oncogenic phenotypes of prostate cancer cells, implying a potential LINC00992-targeted therapy for prostate cancer. +transcription factor target 32781430 hsa-mir-203a Liver Cirrhosis Furthermore, carnosic acid (CA), the major antioxidant compound extracted from rosemary leaves, protected against CCl(4)-induced liver fibrosis through the miR-203a-3p/p66Shc axis. Collectively, these results suggest that p66Shc, which is directly suppressed by miR-203a-3p, is a key regulator of liver fibrosis. +circulation_biomarker_prognosis_down 32781341 hsa-mir-450b Multiple Sclerosis Here, we observed marked elevation of Rho-associated protein kinase 2 (ROCK2) along with significant downregulation of miRNAs 300 and 450b-5p expressions in the serum of 39 RRMS and 35 SPMS Egyptian patients compared to healthy controls. Notably, these biomarkers effectively discriminated RRMS from SPMS patients with miR-450b-5p showing the highest prognostic power. +transcription factor target 32781258 hsa-mir-223 Inflammation CONCLUSIONS: KJL is able to inhibit pyroptosis to alleviate UC, but these suppression effects were not mediated through miR-223 regulation. +transcription factor target 32781258 hsa-mir-223 Colitis CONCLUSIONS: KJL is able to inhibit pyroptosis to alleviate UC, but these suppression effects were not mediated through miR-223 regulation. +other 32781248 hsa-mir-7 Hereditary pancreatitis However, the interaction between miR-7 and the HPO axis remains unclear. Together, these results indicate that miR-7 acts as a potential switch in the feedback loop of the HPO axis by regulating gonadotropins. +lncRNA target 32781208 hsa-mir-155 Inflammation We also found that microRNA-155 played a key role in regulating the production of inflammatory factors TNF-alpha, IL-1beta, and IL-6, and the pre-miRNA-155 inhibitor reversed the Pb-induced inflammation. In conclusion, these in vitro and in vivo findings suggest that oxidative stress and the MAPKs are involved in the Pb-induced inflammasome response, and the production of microRNA-155 aggravated the occurrence of inflammation in carp head kidney. +lncRNA target 32781006 hsa-mir-92a Lupus Erythematosus, Systemic Taken together, our results indicate that the GAS5/miR-92a-3p/E4BP4 pathway plays an important role in inhibiting CD4(+) T cell activation in SLE, thus providing a potential therapeutic target for SLE treatment. +genetics_overexpression_promote 32780563 hsa-mir-5683 Stomach Neoplasms MiR-5683 overexpression may thus become a new treatment strategy for GC. +other 32780490 hsa-mir-7109 Carcinoma, Renal Cell Siglec-15 in immune evasion in ccRCC, which offers significant opportunity for both therapeutic intervention and diagnostic/prognostic exploitations. +other 32780449 hsa-mir-197 psoriasis 1 MicroRNA3p (miR-197) expression is downregulated in psoriatic lesions compared to normal or uninvolved skin in patients with psoriasis. +other 32780418 hsa-mir-133 Mitral Valve Insufficiency Moreover, the increased risk for adverse outcome in HFrEF patients with severe sMR conveyed by miR-133a might indicate irreversible myocardial damage. +other 32780418 hsa-mir-133a Mitral Valve Insufficiency Moreover, the increased risk for adverse outcome in HFrEF patients with severe sMR conveyed by miR-133a might indicate irreversible myocardial damage. +other 32780359 hsa-mir-29b Pre-Eclampsia Altogether, our findings demonstrated that silencing of HDAC4 could trigger cell autophagy and apoptosis directly by miR-29b in placental trophoblast cells of PE. +lncRNA target 32780053 hsa-mir-101 Carcinoma, Hepatocellular This finding suggests that HCSP4-Lipo-DOX-miR101 can cause DOX-resistant HCC cell death and growth inhibition based on the targeting of MDR-related genes by miR-101. +lncRNA target 32780053 hsa-mir-101 Prolactinoma This finding suggests that HCSP4-Lipo-DOX-miR101 can cause DOX-resistant HCC cell death and growth inhibition based on the targeting of MDR-related genes by miR-101. +genetics_knock down_promote 32779991 hsa-mir-497 Ovarian Neoplasms 3p inhibition could partly reverse the inhibitory effect of ELFN1-AS1 silencing on proliferation, migration and invasion of SKOV3 cell lines. +circRNA target 32779548 hsa-mir-375 Osteosarcoma Meanwhile, miR-375 inhibition overturned the suppressive effects of silencing hsa_circRNA_0008035 on OSA cell behaviors. In conclusion, silencing hsa_circRNA_0008035 exerted repressive function on OSA cell growth and migration and Notch pathway by accelerating miR-375. +other 32779443 hsa-mir-133 Cardiomegaly Recent studies have shown that miR- 1 and miR-133 are key regulators of cardiac hypertrophy. +other 32779443 hsa-mir-1 Cardiomegaly Recent studies have shown that miR- 1 and miR-133 are key regulators of cardiac hypertrophy. +other 32779440 hsa-mir-423 Breast Neoplasms CONCLUSION: The data suggested that hsa-miR-423 rs6505162 could be considered as a novel risk factor in breast cancer pathogenesis in Isfahan province of Iran. +transcription factor target 32779334 hsa-mir-20a Epilepsy Overall, we concluded that silencing miR-20a-5p inhibits axonal growth and neuronal branching and prevents epileptogenesis through RGMa-RhoA-mediated synaptic plasticity in the PTZ-induced epilepsy model, thereby providing a possible strategy to prevent epileptogenesis. +other 32779194 hsa-mir-363 Glioma 3p sponge. +genetics_knock down_promote 32779154 hsa-mir-655 Glioma 3p downregulation could neutralize the suppressive effects of NFIA-AS2 knockdown on glioma progression. +lncRNA target 32779153 hsa-mir-126a Sleep Apnea, Obstructive These findings suggest that miR-126a-3p might be a novel potential therapeutic target for the treatment of OSAS-hypertension. +transcription factor target 32779043 hsa-mir-188 Alzheimer Disease However, the roles and molecular basis of Ber and miRNA-188 in the treatment of AD need to be further explored. These results suggested that Ber accelerated cell viability and suppressed caspase-3 activity and apoptotic rate possible by miR-188/NOS1 pathway, implying the treatment of Ber as an underlying effective drug for AD patients. +lncRNA target 32778797 hsa-mir-20a Osteoporosis Taken together, our findings revealed that DANCR and miR-320a regulated the Wnt/beta-catenin signaling pathway during osteogenic differentiation in osteoporosis through CTNNB1 inhibition. +circRNA target 32778770 hsa-mir-144 Carcinoma, Non-Small-Cell Lung 5p directly targeted the 3'-UTR of CDKL1 to regulate cell cycle of NSCLC cells. +transcription factor target 32778238 hsa-mir-34a Liver Neoplasms CONCLUSION: Our results suggest that miR-34a-5p could inhibit the invasion and metastasis of hepatoma cells by targeting YY1-mediated MYCT1 transcriptional repression. +genetics_knock down_suppress 32777750 hsa-mir-221 Glioma Furthermore, we also demonstrated that miR-221 and miR-10b are specifically involved in Hippo signaling via LATS1 regulation and that their knockdown significantly decreased glioma cell proliferation. This preliminary data confirmed the crucial role of the Hippo pathway in cancer and suggested that miR-221 and miR-10b could be potential therapeutic targets for glioma treatment. +genetics_knock down_suppress 32777750 hsa-mir-10b Glioma Furthermore, we also demonstrated that miR-221 and miR-10b are specifically involved in Hippo signaling via LATS1 regulation and that their knockdown significantly decreased glioma cell proliferation. This preliminary data confirmed the crucial role of the Hippo pathway in cancer and suggested that miR-221 and miR-10b could be potential therapeutic targets for glioma treatment. +transcription factor target 32777532 hsa-mir-24 Neuralgia Collectively, our study suggests that cZRNAB1 regulated Wnt5a/beta-Catenin Signaling expression via miR +genetics_overexpression_promote 32777446 hsa-mir-646 Breast Neoplasms Knocking out of the HDAC2 and overexpression of miR-646 inhibited breast cancer cell growth but promoted cell death, while untreated groups showed inverse results. +other 32777238 hsa-let-7b Kidney Diseases The current study aimed to investigate the involvement of microRNAs let-7b, 26b, and 34a, and the modulating impact of PTX on CIS-induced nephrotoxicity. +lncRNA target 32776826 hsa-mir-20a Diabetic Retinopathy The current study aimed to investigate the roles of SIRT1/miR-20a/Yse-associated protein (YAP)/hypoxia-inducible factor 1 alpha (HIF1alpha)/vascular endothelial growth factor A (VEGFA) in DR. Taken together, the key findings of our study suggest that upregulation of SIRT1 inhibits the development of DR via miR-20a-induced downregulation of YAP/HIF1alpha/VEGFA. +circulation_biomarker_diagnosis_ns 32776748 hsa-mir-152 Ischemic Stroke 3p in the circulating system may be a promising strategy for the prevention and treatment of AIS. +circulation_biomarker_diagnosis_ns 32776741 hsa-mir-15a Coronary Artery Disease RESULTS: The results elucidated a significantly decreased expression of miR-15a in peripheral blood samples from CAD patients compared to non-CAD controls (p < 0.01). +other 32776731 hsa-mir-124a Diabetes Mellitus, Type 2 BACKGROUND: Recent evidence indicates that TRIB3 and miR-124 levels have been deregulated in type 2 diabetes (T2D); however, the simultaneous evaluation of these markers in diabetic patients has not been investigated to date. These findings suggest that miR-124a may affect T2D incidence and progression by modulating the expression of TRIB3 protein level. +other 32776731 hsa-mir-124 Diabetes Mellitus, Type 2 BACKGROUND: Recent evidence indicates that TRIB3 and miR-124 levels have been deregulated in type 2 diabetes (T2D); however, the simultaneous evaluation of these markers in diabetic patients has not been investigated to date. These findings suggest that miR-124a may affect T2D incidence and progression by modulating the expression of TRIB3 protein level. +transcription factor target 32776463 hsa-mir-590 Dyspepsia 5p) that target genes associated with ionic transport were upregulated in FD. +transcription factor target 32776463 hsa-mir-32 Dyspepsia 5p) that target genes associated with ionic transport were upregulated in FD. +other 32776229 hsa-mir-31 Leukemia Interestingly, miR3p expression was also associated with GC-resistance in patient leukemia cells taken at diagnosis. +lncRNA target 32775453 hsa-mir-520h Breast Neoplasms Therefore, our findings showed that miR-520h targeted the OTUD3-PTEN axis to drive paclitaxel resistance, and this miR might be an important potential target for breast cancer treatment. +circulation_biomarker_diagnosis_down 32775445 hsa-mir-16 Atherosclerosis RESULTS: Compared with the normal control, miR-16 was downregulated in the plasma and peripheral blood mononuclear cell of CAD patients, and its expression level was negatively associated with IL-6 and the severity of CAD evaluated by the Gensini score, but positively related with IL-10. +other 32775420 hsa-mir-155 Inflammatory Bowel Diseases 5p, and E-cadherin (CDH1) genes associated with IBD, in 67 tissue samples: 28 inflamed mucosa samples (n = 16 UC, n = 12 CD), 28 adjacent normal colonic mucosa (n = 16 UC, n = 12 CD), and 11 normal mucosa from healthy patients using reverse transcription real-time RT-PCR. +other 32775420 hsa-mir-1 Inflammatory Bowel Diseases 5p, and E-cadherin (CDH1) genes associated with IBD, in 67 tissue samples: 28 inflamed mucosa samples (n = 16 UC, n = 12 CD), 28 adjacent normal colonic mucosa (n = 16 UC, n = 12 CD), and 11 normal mucosa from healthy patients using reverse transcription real-time RT-PCR. +other 32775420 hsa-mir-1 Crohn Disease 5p, and E-cadherin (CDH1) genes associated with IBD, in 67 tissue samples: 28 inflamed mucosa samples (n = 16 UC, n = 12 CD), 28 adjacent normal colonic mucosa (n = 16 UC, n = 12 CD), and 11 normal mucosa from healthy patients using reverse transcription real-time RT-PCR. +other 32775420 hsa-mir-21 Inflammatory Bowel Diseases 5p, and E-cadherin (CDH1) genes associated with IBD, in 67 tissue samples: 28 inflamed mucosa samples (n = 16 UC, n = 12 CD), 28 adjacent normal colonic mucosa (n = 16 UC, n = 12 CD), and 11 normal mucosa from healthy patients using reverse transcription real-time RT-PCR. +other 32775420 hsa-mir-155 Crohn Disease 5p, and E-cadherin (CDH1) genes associated with IBD, in 67 tissue samples: 28 inflamed mucosa samples (n = 16 UC, n = 12 CD), 28 adjacent normal colonic mucosa (n = 16 UC, n = 12 CD), and 11 normal mucosa from healthy patients using reverse transcription real-time RT-PCR. +other 32775420 hsa-mir-146a Crohn Disease 5p, and E-cadherin (CDH1) genes associated with IBD, in 67 tissue samples: 28 inflamed mucosa samples (n = 16 UC, n = 12 CD), 28 adjacent normal colonic mucosa (n = 16 UC, n = 12 CD), and 11 normal mucosa from healthy patients using reverse transcription real-time RT-PCR. +other 32775420 hsa-mir-125b-1 Inflammatory Bowel Diseases 5p, and E-cadherin (CDH1) genes associated with IBD, in 67 tissue samples: 28 inflamed mucosa samples (n = 16 UC, n = 12 CD), 28 adjacent normal colonic mucosa (n = 16 UC, n = 12 CD), and 11 normal mucosa from healthy patients using reverse transcription real-time RT-PCR. +other 32775420 hsa-mir-21 Crohn Disease 5p, and E-cadherin (CDH1) genes associated with IBD, in 67 tissue samples: 28 inflamed mucosa samples (n = 16 UC, n = 12 CD), 28 adjacent normal colonic mucosa (n = 16 UC, n = 12 CD), and 11 normal mucosa from healthy patients using reverse transcription real-time RT-PCR. +other 32775420 hsa-mir-125b-1 Crohn Disease 5p, and E-cadherin (CDH1) genes associated with IBD, in 67 tissue samples: 28 inflamed mucosa samples (n = 16 UC, n = 12 CD), 28 adjacent normal colonic mucosa (n = 16 UC, n = 12 CD), and 11 normal mucosa from healthy patients using reverse transcription real-time RT-PCR. +other 32775420 hsa-mir-146a Inflammatory Bowel Diseases 5p, and E-cadherin (CDH1) genes associated with IBD, in 67 tissue samples: 28 inflamed mucosa samples (n = 16 UC, n = 12 CD), 28 adjacent normal colonic mucosa (n = 16 UC, n = 12 CD), and 11 normal mucosa from healthy patients using reverse transcription real-time RT-PCR. +other 32775417 hsa-mir-204 Breast Neoplasms CHRDL1. +lncRNA target 32775413 hsa-mir-637 Osteosarcoma circHIPK3 could promote STAT3 expression via interacting with miR-637 in OS cells. In conclusion, our research uncovered an important role of the circHIPK3/miR-637/STAT3 pathway in the migration and invasion of OS cells and suggested that circHIPK3 may be a prognostic marker and a promising therapeutic target for OS. +other 32775300 hsa-mir-429 Stomach Neoplasms PD-L1 Under Regulation of miR-429 Influences the Sensitivity of Gastric Cancer Cells to TRAIL by Binding of EGFR. +circulation_biomarker_diagnosis_up 32774915 hsa-mir-22 Myocardial Infarction CONCLUSIONS: The expression of serum miRNA-22 in CSF is upregulated compared to that in subjects with normal coronary flow and shows relatively high clinical diagnostic efficiency, suggesting a new potential biomarker for the early diagnosis of CSF. +genetics_GWAS 32774793 hsa-mir-499 Squamous Cell Carcinoma of Head and Neck Materials and Methods In this case-control pilot study total of 112 participants including 56 histopathlogically confirmed oral and oropharyngeal SCC patients and 56 age- and sex-matched controls were included The mir-499 rs3746444 T/C polymorphism was detected using polymerase chain reaction-restriction fragment length polymorphism method. Conclusion The results of the present study indicated that the polymorphisms of mir-499 are not associated with the risk of oral and oropharyngeal SCC in Iranian population. +tissue_expression_ns 32774757 hsa-mir-155 Gastritis Effects of alkaline water intake on gastritis and miRNA expression (miR-7, miR-155, miR-135b and miR-29c). In this study, it was evaluated the expression of the miRNAs miR-29c, miR-7, miR-155, and miR-135b in the gastric tissue of patients with gastritis before and after the consumption of alkaline water (pH range from 8.0 to 10.0), as well as the clinic pathological characteristics. +tissue_expression_up 32774757 hsa-mir-135b Gastritis In this study, it was evaluated the expression of the miRNAs miR-29c, miR-7, miR-155, and miR-135b in the gastric tissue of patients with gastritis before and after the consumption of alkaline water (pH range from 8.0 to 10.0), as well as the clinic pathological characteristics. +tissue_expression_ns 32774757 hsa-mir-7 Gastritis Effects of alkaline water intake on gastritis and miRNA expression (miR-7, miR-155, miR-135b and miR-29c). In this study, it was evaluated the expression of the miRNAs miR-29c, miR-7, miR-155, and miR-135b in the gastric tissue of patients with gastritis before and after the consumption of alkaline water (pH range from 8.0 to 10.0), as well as the clinic pathological characteristics. +tissue_expression_up 32774757 hsa-mir-29c Gastritis In this study, it was evaluated the expression of the miRNAs miR-29c, miR-7, miR-155, and miR-135b in the gastric tissue of patients with gastritis before and after the consumption of alkaline water (pH range from 8.0 to 10.0), as well as the clinic pathological characteristics. +lncRNA target 32774748 hsa-mir-515 Carcinoma, Non-Small-Cell Lung Collectively, this research identified the oncogenic role of circMAGI3 in the tumorigenesis through miR +lncRNA target 32774737 hsa-mir-340 Adenocarcinoma of Lung Collectively, our results indicated TGFB2-AS1/miR5p/EDNRB axis plays crucial roles in regulating LUAD progression, indicating TGFB2-AS1 may be a novel therapeutic target for LUAD. +lncRNA target 32774734 hsa-mir-181a Carcinoma, Hepatocellular Collectively, our results indicate that HBV infection exacerbates PTEN defects in hepatocellular carcinoma through upregulation of miR-181a/362/382/19a. Our work implicates miR-181a/362/382/19a and PTEN as potential biomarkers and targets for novel prognostic, diagnostic, and therapeutic strategies targeting HBV-related HCC. +lncRNA target 32774724 hsa-mir-638 Carcinoma, Renal Cell To explore the effects of miR-638 on cell migration, invasion, viability, and apoptosis of RCC cells, wound scratch, transwell, MTT, CCK-8, and flow cytometry assays were performed. +lncRNA target 32774717 hsa-mir-486 Stomach Neoplasms The results of this study are suggestive of anticancer role of solasonine against the gastric cancer via modulation miR +other 32774715 hsa-mir-125b Breast Neoplasms The lncRNA XIST promotes the progression of breast cancer by sponging miR-125b-5p to modulate NLRC5. +lncRNA target 32774714 hsa-mir-107 Squamous Cell Carcinoma of Head and Neck Mechanistically, upregulation of miR-107 by circ_BICD2-silenced inhibited tumor growth by downregulating the HK2-mediated Warburg effect in OSCC. In conclusion, our findings suggested that circ_BICD2-deficient exerted anti-tumorigenesis and anti-glycolysis in OSCC by sponging miR-107 to downregulate HK2 expression, which provided a new potential therapeutic biomarker for OSCC clinical treatment. +genetics_knock down_suppress 32774713 hsa-mir-876 Osteosarcoma Notably, knockdown of miR +lncRNA target 32774700 hsa-mir-449a Inflammation CONCLUSION: Taken together, these results suggest that SAA could increase miR-449a level and then inhibit DDK1 expression to activate Wnt/beta-catenin pathway, leading to the alleviation of cerebral ischemia/reperfusion injury in vivo and in vitro. +lncRNA target 32774700 hsa-mir-449a Reperfusion Injury, Cerebral Ischemia CONCLUSION: Taken together, these results suggest that SAA could increase miR-449a level and then inhibit DDK1 expression to activate Wnt/beta-catenin pathway, leading to the alleviation of cerebral ischemia/reperfusion injury in vivo and in vitro. +other 32774515 hsa-mir-16 Genital Neoplasms, Female CONCLUSION: Low expression level of miR-16 is an indicator for poor prognosis of solid cancer patients, particularly in reproductive system cancers. +circulation_biomarker_diagnosis_up 32774503 hsa-mir-23b Carcinoma, Non-Small-Cell Lung Compared with the patients with pneumonia and the healthy subjects, the patients with NSCLC exhibited a higher level of serum exosomal miR-23b-3p. +target gene 32774496 hsa-mir-212 Carcinoma, Hepatocellular MicroRNA-212-3p inhibits paclitaxel resistance through regulating epithelial-mesenchymal transition, migration and invasion by targeting ZEB2 in human hepatocellular carcinoma. +target gene 32774482 hsa-mir-489 Urinary Bladder Neoplasms miR-489-3p inhibits proliferation and migration of bladder cancer cells through downregulation of histone deacetylase 2. +lncRNA target 32774481 hsa-mir-140 Carcinoma, Non-Small-Cell Lung In conclusion, the present results demonstrated a novel mechanism for OIP5-AS1-induced metastatic phenotypes of NSCLC via the miR +other 32774477 hsa-mir-200b Thyroid Carcinoma, Anaplastic The current study suggested that miR-200b may regulate the expression levels of mesenchymal markers such as vimentin and ZEB1 in ATC and may promote mesenchymal-to-epithelial transition. +lncRNA target 32774360 hsa-mir-34a Diabetes Mellitus CONCLUSION: Our cumulative results suggested that hyperoside inhibits the proliferation of SV40-MES13 cells through the suppression of the ERK/CREB/miRNA-34a signaling pathway, which provides new insight to the current investigation on therapeutic strategies for diabetic nephropathy. +lncRNA target 32774360 hsa-mir-34a Diabetic Nephropathies CONCLUSION: Our cumulative results suggested that hyperoside inhibits the proliferation of SV40-MES13 cells through the suppression of the ERK/CREB/miRNA-34a signaling pathway, which provides new insight to the current investigation on therapeutic strategies for diabetic nephropathy. +lncRNA target 32774168 hsa-mir-361 Glioma In addition, circPOSTN targetedly regulated TPX2 expression in glioma cells via sponging miR +lncRNA target 32774166 hsa-mir-143 Uterine Cervical Neoplasms 3p mimic/inhibitor was designed and transfected into CC cell lines to investigate their correlations and potential impacts on cell function. +genetics_overexpression_promote 32774164 hsa-mir-195 Ovarian Neoplasms 5p also depleted proliferation, migration, and invasion but promoted apoptosis of OC cells, while FHL2 overexpression overturned these influences. +genetics_knock down_promote 32774162 hsa-mir-450b Uterine Cervical Neoplasms Finally, miR-450b-5p inhibitor or RAB10 upregulation counteracted LINC00441 knockdown-mediated function on the development of CC. CONCLUSIONS: LINC00441 drives CC progression by targeting miR-450b-5p/RAB10 axis, which might provide new idea for researching CC-related molecular mechanism. +lncRNA target 32774161 hsa-mir-4500 Carcinoma, Hepatocellular CONCLUSION: TRG-AS1 regulates HCC progression by targeting miR-4500/BACH1 axis. +lncRNA target 32774154 hsa-mir-326 Carcinoma, Hepatocellular And the repressive influence on malignant behaviors of HCC cells mediated by hsa_circ_0000517 inhibition was reversed by miR-326 inhibitors. +other 32774146 hsa-mir-19a Norrie disease The results suggested that the miR-17 approximately 92 cluster members miR5p, miR-18a, miR-19a, miR-19b, miR-20a, and miR-92a were upregulated in the renal biopsy tissue of DN patients and HG-treated MPC5. +other 32774146 hsa-mir-92a Norrie disease The results suggested that the miR-17 approximately 92 cluster members miR5p, miR-18a, miR-19a, miR-19b, miR-20a, and miR-92a were upregulated in the renal biopsy tissue of DN patients and HG-treated MPC5. +other 32774146 hsa-mir-17 Norrie disease The results suggested that the miR-17 approximately 92 cluster members miR5p, miR-18a, miR-19a, miR-19b, miR-20a, and miR-92a were upregulated in the renal biopsy tissue of DN patients and HG-treated MPC5. +other 32774146 hsa-mir-20a Norrie disease The results suggested that the miR-17 approximately 92 cluster members miR5p, miR-18a, miR-19a, miR-19b, miR-20a, and miR-92a were upregulated in the renal biopsy tissue of DN patients and HG-treated MPC5. +other 32774146 hsa-mir-18a Norrie disease The results suggested that the miR-17 approximately 92 cluster members miR5p, miR-18a, miR-19a, miR-19b, miR-20a, and miR-92a were upregulated in the renal biopsy tissue of DN patients and HG-treated MPC5. +other 32774146 hsa-mir-19b Norrie disease The results suggested that the miR-17 approximately 92 cluster members miR5p, miR-18a, miR-19a, miR-19b, miR-20a, and miR-92a were upregulated in the renal biopsy tissue of DN patients and HG-treated MPC5. +transcription factor target 32774142 hsa-mir-183 Esophageal Neoplasms CONCLUSION: ABI3BP and miR-183 can be considered potential biomarkers for the diagnosis of patients with EC and can be effective targets for antitumor therapy. +lncRNA target 32773107 hsa-mir-144 Acquired Immunodeficiency Syndrome CONCLUSIONS: Our results suggest that inhibiting miR-144 or interfering with its deleterious effects on Nrf2 attenuates HIV +circulation_biomarker_diagnosis_ns 32772928 hsa-mir-23a Polycystic Ovary Syndrome RESULTS: Downregulation of miR-23a was observed in serum of PCOS patients compared with the healthy control, suggesting the inhibitory effect of miR-23a in PCOS. +lncRNA target 32772818 hsa-mir-9 lung squamous cell carcinoma CONCLUSION: MicroRNA9 inhibits proliferation and migration of lung squamous cell carcinoma cells by inhibiting neuron-restricted silencing factor/epidermal growth factor receptor axis. +transcription factor target 32772782 hsa-mir-942 Melanoma Suppression of miR +transcription factor target 32772776 hsa-mir-128 Obesity CONCLUSION: It is demonstrated that the miRJNK signaling pathway is a potential therapeutic target for the treatment of obesity. +genetics_knock down_suppress 32772636 hsa-mir-145 Retinoblastoma 5p inhibitor and E2F3 overexpression both partly reversed the malignant phenotypes of RB cells affected by CASC9 knockdown. +lncRNA target 32772311 hsa-mir-761 Atherosclerosis We demonstrated that miR-761 was able to repress foam cell formation and reduce the production of atherogenic inflammatory cytokines IL-1beta and IL-18 in an autophagy-dependent manner in atherosclerosis, possibly via mTOR-ULK1 signaling pathway. +genetics_overexpression_promote 32772270 hsa-mir-148a Rift Valley Fever PURPOSE: To evaluate whether miR-148a-3p overexpression is associated with disrupted decidualization of recurrent implantation failure (RIF). +lncRNA target 32771556 hsa-mir-98 Inflammation one alleviates inflammation by downregulating miR +circulation_biomarker_diagnosis_up 32771555 hsa-let-7a Colorectal Neoplasms KEY FINDINGS: Circulating serum miR-19a, miR-20a, miR-150, and let-7a were significantly up-regulated in CRC patients, while miR-143 and miR-145 showed a significant down-regulation. miR-19a, miR-20a, miR-143, miR-145, miR-150, and let-7a) in serum as a non-invasive biomarker for CRC diagnosis. +circulation_biomarker_diagnosis_up 32771555 hsa-mir-19a Colorectal Neoplasms KEY FINDINGS: Circulating serum miR-19a, miR-20a, miR-150, and let-7a were significantly up-regulated in CRC patients, while miR-143 and miR-145 showed a significant down-regulation. miR-19a, miR-20a, miR-143, miR-145, miR-150, and let-7a) in serum as a non-invasive biomarker for CRC diagnosis. +circulation_biomarker_diagnosis_up 32771555 hsa-mir-143 Colorectal Neoplasms KEY FINDINGS: Circulating serum miR-19a, miR-20a, miR-150, and let-7a were significantly up-regulated in CRC patients, while miR-143 and miR-145 showed a significant down-regulation. miR-19a, miR-20a, miR-143, miR-145, miR-150, and let-7a) in serum as a non-invasive biomarker for CRC diagnosis. +circulation_biomarker_diagnosis_up 32771555 hsa-mir-150 Colorectal Neoplasms KEY FINDINGS: Circulating serum miR-19a, miR-20a, miR-150, and let-7a were significantly up-regulated in CRC patients, while miR-143 and miR-145 showed a significant down-regulation. miR-19a, miR-20a, miR-143, miR-145, miR-150, and let-7a) in serum as a non-invasive biomarker for CRC diagnosis. +circulation_biomarker_diagnosis_up 32771555 hsa-mir-145 Colorectal Neoplasms KEY FINDINGS: Circulating serum miR-19a, miR-20a, miR-150, and let-7a were significantly up-regulated in CRC patients, while miR-143 and miR-145 showed a significant down-regulation. miR-19a, miR-20a, miR-143, miR-145, miR-150, and let-7a) in serum as a non-invasive biomarker for CRC diagnosis. +circulation_biomarker_diagnosis_up 32771555 hsa-mir-20a Colorectal Neoplasms KEY FINDINGS: Circulating serum miR-19a, miR-20a, miR-150, and let-7a were significantly up-regulated in CRC patients, while miR-143 and miR-145 showed a significant down-regulation. miR-19a, miR-20a, miR-143, miR-145, miR-150, and let-7a) in serum as a non-invasive biomarker for CRC diagnosis. +lncRNA target 32771526 hsa-mir-206 Ovarian Neoplasms Collectively, our findings suggest that HOTAIR relieves the inhibition of TBX3 expression mediated by miR-206 in OCSCs and provide novel therapeutic targets for the treatment of ovarian cancer. +other 32771440 hsa-mir-4488 Aspergillosis 5p, miR-99b-5p, and miR-4488) that were upregulated and the pair (miR-4454+miR-7975) that was downregulated in IA group vs controls. +other 32771440 hsa-mir-7975 Aspergillosis 5p, miR-99b-5p, and miR-4488) that were upregulated and the pair (miR-4454+miR-7975) that was downregulated in IA group vs controls. +other 32771440 hsa-mir-4454 Aspergillosis 5p, miR-99b-5p, and miR-4488) that were upregulated and the pair (miR-4454+miR-7975) that was downregulated in IA group vs controls. +other 32771440 hsa-mir-145 Aspergillosis 5p, miR-99b-5p, and miR-4488) that were upregulated and the pair (miR-4454+miR-7975) that was downregulated in IA group vs controls. +other 32771440 hsa-mir-424 Aspergillosis 5p, miR-99b-5p, and miR-4488) that were upregulated and the pair (miR-4454+miR-7975) that was downregulated in IA group vs controls. +other 32771045 hsa-mir-28 Pancreatic Carcinoma CONCLUSIONS: This study is the first to characterize the oncogenic function of the long noncoding RNA LINC00514 in pancreatic cancer progression by acting as a competing endogenous RNA (ceRNA) of miR5p to upregulate Rap1b expression. +circulation_biomarker_diagnosis_up 32770994 hsa-mir-2861 Osteoporosis RESULT: We found that the expression of SNHG14 was enhanced, while the expression of miR-2861 was suppressed in serum and hMSCs from patients with osteoporosis. +genetics_knock down_promote 32770578 hsa-mir-448 Arthritis, Rheumatoid Further overexpression of miR-448 reversed the effects of OIP5-AS1, while overexpression of PON1 inhibited RA-FLS growth and inflammation. +lncRNA target 32770454 hsa-mir-361 Glioblastoma The following rescue assays demonstrated that COX10-AS1 promoted GBM cell proliferation and inhibited GBM cell apoptosis through ACTG1 up-regulation at a miR +lncRNA target 32770398 hsa-mir-27b Osteoarthritis PCAT-1 could promote the apoptosis of OA and normal chondrocytes through binding with miR-27b-3p. CONCLUSIONS: Based on the comparisons and analysis, we could conclude that lncRNA PCAT-1 regulated the apoptosis of chondrocytes through sponging miR-27b-3p in OA. +lncRNA target 32770294 hsa-mir-920 Glioblastoma These findings implied that miR-920/LSP1 was a potential therapeutic target for glioblastoma treatment. +genetics_overexpression_promote 32770182 hsa-mir-146a Leukemia, Lymphocytic, Chronic, B-Cell USP16 was confirmed as a direct target of miR-146a and USP16 overexpression in BM-MSCs abrogated the CLL-Exo-mediated up-regulation of CAF markers. +circulation_biomarker_diagnosis_ns 32770080 hsa-mir-1 Pre-Eclampsia In the present study, we found increases in TNF-alpha and miR-31/155 levels and reduced numbers of circulating EPCs in patients with preeclampsia. Our data provide a new role for NF-kappaB-dependent miR-31/155 in EPC dysfunction under the pathogenic conditions of inflammation-associated vascular diseases, including preeclampsia. +other 32770080 hsa-mir-1 Vascular Diseases Our data provide a new role for NF-kappaB-dependent miR-31/155 in EPC dysfunction under the pathogenic conditions of inflammation-associated vascular diseases, including preeclampsia. +other 32770080 hsa-mir-155 Vascular Diseases Our data provide a new role for NF-kappaB-dependent miR-31/155 in EPC dysfunction under the pathogenic conditions of inflammation-associated vascular diseases, including preeclampsia. +circulation_biomarker_diagnosis_ns 32770080 hsa-mir-155 Pre-Eclampsia In the present study, we found increases in TNF-alpha and miR-31/155 levels and reduced numbers of circulating EPCs in patients with preeclampsia. Our data provide a new role for NF-kappaB-dependent miR-31/155 in EPC dysfunction under the pathogenic conditions of inflammation-associated vascular diseases, including preeclampsia. +other 32769986 hsa-mir-93 Creutzfeldt-Jakob Disease, Sporadic 5p and hsa-miR-106b-3p. +other 32769986 hsa-mir-106b Creutzfeldt-Jakob Disease, Sporadic 5p and hsa-miR-106b-3p. +other 32769986 hsa-let-7i Creutzfeldt-Jakob Disease, Sporadic 5p and hsa-miR-106b-3p. +other 32769986 hsa-mir-16 Creutzfeldt-Jakob Disease, Sporadic 5p and hsa-miR-106b-3p. +circRNA target 32768951 hsa-mir-1182 Carcinoma, Non-Small-Cell Lung MiR-1182 targeted KLF8 to hinder NSCLC development. +circRNA target 32768931 hsa-mir-376b Osteoporosis CONCLUSION: It was firstly uncovered in present study that circ_0024097 attenuated osteoporosis through promoting osteogenic differentiation via miR-376b-3p/YAP1 axis and Wnt/beta-catenin pathway. +lncRNA target 32768929 hsa-mir-582 Pulmonary Disease, Chronic Obstructive CONCLUSION: Our data revealed that NNT-AS1 played a promoting role in smoking-induced COPD via modulating miR5p/FBXO11 signaling, suggesting a novel potential target for COPD treatment. +lncRNA target 32768781 hsa-mir-515 Pulmonary Disease, Chronic Obstructive Overall, the results show that, by regulating miR5p through a FoxC1/Snail regulatory axis, circ0061052 is involved in the CS-induced EMT and airway remodeling in COPD. +genetics_overexpression_promote 32768506 hsa-mir-139 Colorectal Neoplasms 5p overexpressed CRC cell lines, we found the same results as knocking down c-met, which means that endogenous miR +other 32767932 hsa-mir-375 Laryngeal Neoplasms Subgroup analyses were performed by evaluating the effects of miR-196b, miR-375, and miR-21 on OS and the effects of miR-34c-5p on DFS. +other 32767932 hsa-mir-21 Laryngeal Neoplasms Subgroup analyses were performed by evaluating the effects of miR-196b, miR-375, and miR-21 on OS and the effects of miR-34c-5p on DFS. +other 32767932 hsa-mir-34c Laryngeal Neoplasms Subgroup analyses were performed by evaluating the effects of miR-196b, miR-375, and miR-21 on OS and the effects of miR-34c-5p on DFS. +other 32767932 hsa-mir-196b Laryngeal Neoplasms Subgroup analyses were performed by evaluating the effects of miR-196b, miR-375, and miR-21 on OS and the effects of miR-34c-5p on DFS. +other 32767729 hsa-mir-155 Chemical and Drug Induced Liver Injury Meanwhile, we have shown that miR-155 positively regulates HBeAg-induced macrophage activation and accelerates liver injury. +circulation_biomarker_diagnosis_up 32767662 hsa-mir-520a Carcinoma, Hepatocellular CONCLUSION: Circulating H19 promoted the proliferation, migration and invasion and inhibited the apoptosis of HCC cells treated with Propofol through upregulating LIMK1 via sponging miR-520a-3p. +lncRNA target 32767514 hsa-mir-193 Lung Neoplasms CONCLUSIONS: Our results demonstrated that miR-138 and miR-193 affect cell function by directly targeting and regulating UCA1 in lung cancer. +lncRNA target 32767514 hsa-mir-138 Lung Neoplasms CONCLUSIONS: Our results demonstrated that miR-138 and miR-193 affect cell function by directly targeting and regulating UCA1 in lung cancer. +lncRNA target 32767499 hsa-mir-193a Breast Neoplasms Furthermore, it was found that CirCHIPK3 facilitated cell proliferation, migration, and invasion in BC by regulating miR-193a/HMGB1/PI3K/AKT signaling. CONCLUSIONS: CirCHIPK3 regulated miR-193a/HMGB1/PI3K/AKT signaling to facilitate BC development and progression, providing a novel therapeutic target for BC. +genetics_overexpression_promote 32767336 hsa-mir-106a Aortic Aneurysm, Abdominal To determine the potential role of miR-106a in the pathogenesis of AAA, miR-106a was overexpressed in vascular smooth muscle cells (VSMCs), and then cell viability and apoptosis were evaluated by performing CCK-8 assay and flow cytometry, respectively. +other 32767327 hsa-mir-423 Nasopharyngeal Carcinoma FOXP4-AS1upregulated STMN1 by interacting with miR5p as a competing endogenous RNA (ceRNA) to promote NPC progression. +lncRNA target 32767323 hsa-mir-100 Colorectal Neoplasms 5p on tumor suppressor gene SMAD4. +genetics_knock down_promote 32767322 hsa-mir-199a Colorectal Neoplasms Furthermore, miR-199a inhibitor abrogated the suppressive effect of circUBAP2 knockdown on CRC progression. CONCLUSIONS: Our findings demonstrated that circUBAP2 facilitated CRC progression by sponging miR-199a to upregulate VEGFA. +lncRNA target 32767321 hsa-mir-22 Uterine Cervical Neoplasms RESULTS: Our data suggested that MIR22HG dramatically promoted cervical cancer apoptosis and inhibited invasion by targeting IGF2BP2. CONCLUSIONS: The long noncoding RNA MIR22HG targets IGF2BP2 as a tumour suppressor in cervical cancer. +genetics_knock down_promote 32767319 hsa-mir-124 Osteoarthritis Besides, miR-124 inhibitors reversed the knockdown of CircHIPK3 while si-SOX8 reversed the miR-124 inhibitors effect of apoptosis on OA chondrocytes. +circulation_biomarker_diagnosis_ns 32767318 hsa-mir-27a Osteoarthritis In addition, the in vitro regulation of circTMBIM6 and miR-27a in osteoarthritis was verified by transfection of circTMBIM6 and miR-27a plasmids, and the regulation of miR-27a on MMP13 was also verified. +lncRNA target 32767028 hsa-mir-498 Myocardial Infarction CONCLUSIONS: Our findings reveal that the expression of circ_0068655 can promote cardiomyocyte apoptosis through the modulation of miR +genetics_GWAS 32766473 hsa-mir-548f Non-alcoholic Fatty Liver Disease In stage II, human leukocyte antigen (HLA) in chromosome 6 (chr6) (P = 6.73E-08), microRNA (MIR) MIR548F3 in chr7 (P = 4.25E-07), myosin light chain 2 (MYL2) in chr12 (P = 4.39E-07), and glycoprotein precursor (GPC)6 in chr13 (P = 5.43E-07), as suggested by the GWAS, were assessed by single nucleotide polymorphism (SNP) association analysis of whole NAFLD against non-NAFLD in 9,726 members of the general population. +lncRNA target 32766356 hsa-mir-184 Cardiomyopathy dilated with woolly hair and keratoderma CONCLUSIONS: Our results demonstrate that miR-184 inhibits corneal epithelial cell proliferation and migration via targeting CDC25A, CARM1, and LASP1, suggesting it acts as a negative modulator during CEWH. +lncRNA target 32766250 hsa-mir-23b Sepsis Antagonizing the secretion of EMVs and the miR-23b might be a potential target for the treatment of severe sepsis. +lncRNA target 32766250 hsa-mir-23b Lung Injury Antagonizing the secretion of EMVs and the miR-23b might be a potential target for the treatment of severe sepsis. +other 32766248 hsa-let-7 Stroke let-7 microRNAs (miRs) are critical for regulating immune responses within the BBB, particularly after ischemic stroke. Together, the results of the study indicate that let-7 miRs are critical for mediating endothelial-immune reactions and improving recovery following ischemic stroke. +other 32766179 hsa-mir-181a Wilms Tumor To confirm the differences between cases with poor prognosis, we performed in situ hybridization for three microRNAs in five DAWT and 17 FHWT samples, and only significant differences between adjacent tissues and FHWT tumors were found for miR-181a, miR-200b, and miR-218, in both total pixels and nuclear analyses. +other 32766179 hsa-mir-29a Wilms Tumor To discriminate between miRNA expression FHWTs and healthy controls, the receiver operating characteristic (ROC) curves were obtained; miR-29a AUC was 0.7843. +other 32766179 hsa-mir-200b Wilms Tumor To confirm the differences between cases with poor prognosis, we performed in situ hybridization for three microRNAs in five DAWT and 17 FHWT samples, and only significant differences between adjacent tissues and FHWT tumors were found for miR-181a, miR-200b, and miR-218, in both total pixels and nuclear analyses. +other 32766179 hsa-mir-218 Wilms Tumor MiR-29a and miR-218 showed significant differences in FHWT with low (P = 0.0018) and high (P = 0.0131) expression, respectively. To confirm the differences between cases with poor prognosis, we performed in situ hybridization for three microRNAs in five DAWT and 17 FHWT samples, and only significant differences between adjacent tissues and FHWT tumors were found for miR-181a, miR-200b, and miR-218, in both total pixels and nuclear analyses. +lncRNA target 32766131 hsa-mir-125b Colonic Neoplasms In summary, our study reveals a new mechanism of the DANCR-promoted cisplatin resistance, presenting the lncRNA-DANCR-miR-125b-5p/HK2 axis as a potential target for treating chemoresistant colon cancer. +target gene 32766125 hsa-mir-326 cervical squamous cell carcinoma CircRNA circ_POLA2 Promotes Cervical Squamous Cell Carcinoma Progression via Regulating miR-326/GNB1. +circulation_biomarker_diagnosis_ns 32765820 hsa-mir-20 Obesity RESULTS: The TLDA cards contain 754 human miRNAs; of these, the levels of 8 circulating miRNAs significantly declined (> 2-fold) in obese subjects compared with those in lean subjects, including miR-1227, miR +circulation_biomarker_diagnosis_ns 32765820 hsa-mir-192 Obesity RESULTS: The TLDA cards contain 754 human miRNAs; of these, the levels of 8 circulating miRNAs significantly declined (> 2-fold) in obese subjects compared with those in lean subjects, including miR-1227, miR +circulation_biomarker_diagnosis_ns 32765820 hsa-mir-20b Obesity RESULTS: The TLDA cards contain 754 human miRNAs; of these, the levels of 8 circulating miRNAs significantly declined (> 2-fold) in obese subjects compared with those in lean subjects, including miR-1227, miR +circulation_biomarker_diagnosis_ns 32765820 hsa-mir-24 Obesity RESULTS: The TLDA cards contain 754 human miRNAs; of these, the levels of 8 circulating miRNAs significantly declined (> 2-fold) in obese subjects compared with those in lean subjects, including miR-1227, miR +circulation_biomarker_diagnosis_ns 32765820 hsa-mir-1227 Obesity RESULTS: The TLDA cards contain 754 human miRNAs; of these, the levels of 8 circulating miRNAs significantly declined (> 2-fold) in obese subjects compared with those in lean subjects, including miR-1227, miR +circulation_biomarker_diagnosis_ns 32765820 hsa-mir-378 Obesity RESULTS: The TLDA cards contain 754 human miRNAs; of these, the levels of 8 circulating miRNAs significantly declined (> 2-fold) in obese subjects compared with those in lean subjects, including miR-1227, miR +circulation_biomarker_diagnosis_ns 32765820 hsa-mir-484 Obesity RESULTS: The TLDA cards contain 754 human miRNAs; of these, the levels of 8 circulating miRNAs significantly declined (> 2-fold) in obese subjects compared with those in lean subjects, including miR-1227, miR +circulation_biomarker_diagnosis_ns 32765820 hsa-mir-144 Obesity RESULTS: The TLDA cards contain 754 human miRNAs; of these, the levels of 8 circulating miRNAs significantly declined (> 2-fold) in obese subjects compared with those in lean subjects, including miR-1227, miR +lncRNA target 32765782 hsa-mir-127 Pneumonia 5p may attenuate severe pneumonia by reducing LPS-induced inflammatory cytokine production, and inactivating the AKT and NF-kappaB signaling pathways by targeting TRAF1. +other 32765765 hsa-mir-613 Pancreatic Carcinoma The integrated analysis performed in the current study demonstrated that hsa-miR5p may be used as a potential prognostic marker for pancreatic cancer. +circulation_biomarker_diagnosis_ns 32765703 hsa-mir-27a Pre-Eclampsia The present results suggested that miR-27a expression level was significantly increased in PE placentas and serum. +transcription factor target 32765699 hsa-mir-4262 Inflammatory Bowel Diseases It was thus concluded that miR-4262 may serve a role in the progression of IBD via targeting SIRT1, and miR-4262/SIRT1 may represent a potential target for the diagnosis and treatment of IBD. +lncRNA target 32765698 hsa-mir-28 Alzheimer Disease 3p level to alleviate the symptoms of AD patients, and miR +other 32765697 hsa-mir-135 Fractures, Bone 3p and miR-135a-5p were differentially expressed between controls and osteoporotic patients with fractures. +other 32765697 hsa-mir-576 Osteoporosis 3p and miR-135a-5p were differentially expressed between controls and osteoporotic patients with fractures. +other 32765697 hsa-mir-135 Osteoporosis 3p and miR-135a-5p were differentially expressed between controls and osteoporotic patients with fractures. +other 32765697 hsa-mir-942 Fractures, Bone 3p and miR-135a-5p were differentially expressed between controls and osteoporotic patients with fractures. +other 32765697 hsa-mir-942 Osteoporosis 3p and miR-135a-5p were differentially expressed between controls and osteoporotic patients with fractures. +other 32765697 hsa-mir-188 Osteoporosis 3p and miR-135a-5p were differentially expressed between controls and osteoporotic patients with fractures. +other 32765697 hsa-mir-188 Fractures, Bone 3p and miR-135a-5p were differentially expressed between controls and osteoporotic patients with fractures. +other 32765697 hsa-mir-576 Fractures, Bone 3p and miR-135a-5p were differentially expressed between controls and osteoporotic patients with fractures. +other 32765697 hsa-mir-135a Osteoporosis 3p and miR-135a-5p were differentially expressed between controls and osteoporotic patients with fractures. +other 32765697 hsa-mir-135a Fractures, Bone 3p and miR-135a-5p were differentially expressed between controls and osteoporotic patients with fractures. +other 32765691 hsa-mir-34a Lymphoma, Large B-Cell, Diffuse mRNA expression profile analysis reveals a C-MYC/miR-34a pathway involved in the apoptosis of diffuse large B-cell lymphoma cells induced by Yiqichutan treatment. +target gene 32765688 hsa-mir-96 Colorectal Neoplasms Inhibition of miR-96 enhances the sensitivity of colorectal cancer cells to oxaliplatin by targeting TPM1. +circulation_biomarker_diagnosis_up 32765687 hsa-mir-146a Coronary Disease Expression characteristics of inflammatory factors interleukin-23 and interleukin-35; oxidative stress markers of malondialdehyde, which is a final product of lipid peroxidation; superoxide dismutase; microRNA-126 and microRNA-146a in serum of patients with coronary heart disease were investigated. In conclusion, biomarkers interleukin-23, interleukin-35, malondialdehyde, superoxide dismutase, microRNA-126 and microRNA-146a were abnormally expressed in serum of patients with coronary heart disease, implicating their association with onset and progression of the disease. +circulation_biomarker_diagnosis_up 32765687 hsa-mir-126 Coronary Disease Expression characteristics of inflammatory factors interleukin-23 and interleukin-35; oxidative stress markers of malondialdehyde, which is a final product of lipid peroxidation; superoxide dismutase; microRNA-126 and microRNA-146a in serum of patients with coronary heart disease were investigated. In conclusion, biomarkers interleukin-23, interleukin-35, malondialdehyde, superoxide dismutase, microRNA-126 and microRNA-146a were abnormally expressed in serum of patients with coronary heart disease, implicating their association with onset and progression of the disease. +genetics_overexpression_promote 32765685 hsa-mir-144 Cardiomyopathies However, the exact molecular mechanism underlying miR-144 in cardiac fibrosis remains unknown. The results of the present study demonstrated that miR-144 played a key role in CF activation, partially by targeting CREB, which further suggested that the overexpression of miR-144 may be a promising strategy for the treatment of cardiac fibrosis. +genetics_overexpression_promote 32765679 hsa-mir-140 Adenocarcinoma of Lung 3p overexpression was also found to attenuate cisplatin resistance and reduce stem cell-like properties in LUAD cells by suppressing Wnt/beta-catenin signaling, all of which were reversed by the overexpression of beta-catenin. +genetics_overexpression_suppress 32765678 hsa-mir-19b Osteoarthritis 5p or miR-19b-3p mimic-induced inhibition of OA progression was reversed by EZH2 overexpression. +genetics_knock down_promote 32765677 hsa-mir-365b Carcinoma, Non-Small-Cell Lung Overexpression of miR-365b inhibited NSCLC cell proliferation whilst promoting apoptosis, but miR-365b knockdown promoted NSCLC cell proliferation. +other 32765676 hsa-mir-222 Thyroid Nodule 3p and miRNA-151a-5p were higher, while the level of miRNA138 was lower, in patients with malignant thyroid nodules than those in patients with benign thyroid nodule (P<0.05). +other 32765676 hsa-mir-151a Thyroid Nodule 3p and miRNA-151a-5p were higher, while the level of miRNA138 was lower, in patients with malignant thyroid nodules than those in patients with benign thyroid nodule (P<0.05). +other 32765676 hsa-mir-187 Thyroid Nodule 3p and miRNA-151a-5p were higher, while the level of miRNA138 was lower, in patients with malignant thyroid nodules than those in patients with benign thyroid nodule (P<0.05). +other 32765676 hsa-mir-146b Thyroid Nodule 3p and miRNA-151a-5p were higher, while the level of miRNA138 was lower, in patients with malignant thyroid nodules than those in patients with benign thyroid nodule (P<0.05). +other 32765676 hsa-mir-138 Thyroid Nodule 3p and miRNA-151a-5p were higher, while the level of miRNA138 was lower, in patients with malignant thyroid nodules than those in patients with benign thyroid nodule (P<0.05). +other 32765676 hsa-mir-375 Thyroid Nodule 3p and miRNA-151a-5p were higher, while the level of miRNA138 was lower, in patients with malignant thyroid nodules than those in patients with benign thyroid nodule (P<0.05). +target gene 32765654 hsa-mir-187 Breast Neoplasms miR-187-3p increases gemcitabine sensitivity in breast cancer cells by targeting FGF9 expression. +other 32765095 hsa-mir-186 Stomach Neoplasms circ-NRIP1 Promotes Glycolysis and Tumor Progression by Regulating miR-186-5p/MYH9 Axis in Gastric Cancer. +lncRNA target 32765094 hsa-mir-21 Carcinoma, Hepatocellular Xenograft assay confirmed that paeonol inhibited tumor growth through miR +genetics_knock down_suppress 32765087 hsa-mir-15a Burkitt Lymphoma Knockdown of lncRNA MCM3AP-AS1 Attenuates Chemoresistance of Burkitt Lymphoma to Doxorubicin Treatment via Targeting the miR-15a/EIF4E Axis. +genetics_overexpression_promote 32765078 hsa-mir-31 Carcinoma, Non-Small-Cell Lung 3p was downregulated in NSCLC, which promoted tumor cell proliferation, whereas the overexpression of miR +lncRNA target 32765071 hsa-mir-1298 Glioma CONCLUSION: Our data reveal that SD acts as a cancer-inhibiting agent in glioma via miR +lncRNA target 32765068 hsa-mir-421 Squamous Cell Carcinoma of Head and Neck CONCLUSION: In conclusion, our study reveals that circ-ITCH serves as a tumor suppressor in OSCC partly by regulating miR-421/PDCD4 axis. +lncRNA target 32765065 hsa-mir-577 Glioblastoma Both miR-577 inhibition and BDNF expression enhancement reversed LINC01094 deficiency-mediated inhibition of malignant processes in GBM cells. +other 32765027 hsa-mir-21 Diabetic Nephropathies CONCLUSION: miRNA-377, miRNA-93, miRNA-216a, and miRNA-21 may be implicated in the pathogenesis of DN, while miRNA-25 may have a reno-protective role. +other 32765027 hsa-mir-377 Diabetic Nephropathies This study aimed to describe the expression of miRNA-377, miRNA-93, miRNA-25, miRNA-216a, and miRNA-21 in a sample of type 1 diabetic children and adolescents to explore their association with DN and some indices of kidney injury. +other 32765027 hsa-mir-216a Diabetic Nephropathies CONCLUSION: miRNA-377, miRNA-93, miRNA-216a, and miRNA-21 may be implicated in the pathogenesis of DN, while miRNA-25 may have a reno-protective role. +other 32765027 hsa-mir-25 Diabetic Nephropathies This study aimed to describe the expression of miRNA-377, miRNA-93, miRNA-25, miRNA-216a, and miRNA-21 in a sample of type 1 diabetic children and adolescents to explore their association with DN and some indices of kidney injury. +other 32765027 hsa-mir-93 Diabetic Nephropathies This study aimed to describe the expression of miRNA-377, miRNA-93, miRNA-25, miRNA-216a, and miRNA-21 in a sample of type 1 diabetic children and adolescents to explore their association with DN and some indices of kidney injury. +circulation_biomarker_diagnosis_up 32765026 hsa-mir-770 Diabetic Nephropathies 5p were upregulated in plasma of DM patients and were further upregulated in DN patients. +target gene 32764992 hsa-mir-27b Lung Neoplasms Long Non-Coding RNA TP73-AS1 Promotes the Development of Lung Cancer by Targeting the miR-27b-3p/LAPTM4B Axis. +other 32764987 hsa-mir-125a Thyroid Neoplasms Upregulation of TRIAP1 by the lncRNA MFI2-AS1/miR-125a-5p Axis Promotes Thyroid Cancer Tumorigenesis. +transcription factor target 32764986 hsa-mir-1274a Colonic Neoplasms Upregulated miR-1274a promoted cell proliferation, migration, and invasion of colon cancer cells, while inhibition of miR-1274a suppressed these cellular activities by targeting FOXO4. +target gene 32764979 hsa-mir-27a Breast Neoplasms MicroRNA-27a-3p Reverses Adriamycin Resistance by Targeting BTG2 and Activating PI3K/Akt Pathway in Breast Cancer Cells. +genetics_overexpression_suppress 32764964 hsa-mir-602 Liver Neoplasms We transiently transfected the miR-602 gene into cells that stably overexpressed RASSF1A and examined relevant indicators to elucidate the mechanisms by which miR-602 regulates the RASSF1A/c-Jun N-terminal kinase (JNK) pathway in recurrence and dormancy in liver cancer. +genetics_overexpression_promote 32764959 hsa-mir-188 Leukemia, Promyelocytic, Acute 5p overexpression increased the tumorigenic ability of APL and Ki67 expression, and reduced cell apoptosis in vivo. +lncRNA target 32764941 hsa-mir-214 Osteosarcoma CONCLUSION: This study indicates the potential of functionalized GO-PEI as a vehicle for miRNA inhibitor delivery to treat osteosarcoma with low toxicity and miR-214 can be a good target for osteosarcoma therapy. +circulation_biomarker_diagnosis_up 32764903 hsa-mir-21 Osteoporosis Expression levels of GAS5 and miR-21 were inversely correlated across plasma samples from osteoporosis patients but not the plasma samples from the controls. +other 32764607 hsa-mir-21 Down Syndrome These findings strongly suggest that microRNAs (miR4, miR-21), cytoskeleton remodeling, response to stimuli, and inflammation can impact resistance to tumorigenesis in DS patients. +other 32764512 hsa-mir-7112 Immunoglobulin G4-Related Disease 3p as the best discriminators of IgG4-ROD and orbital MALT lymphoma, respectively. +other 32764512 hsa-mir-202 Immunoglobulin G4-Related Disease 3p as the best discriminators of IgG4-ROD and orbital MALT lymphoma, respectively. +other 32764455 hsa-mir-944 Uterine Cervical Neoplasms Thus, associations between miR-944 and DeltaNp63 in cervical cancer could help to elucidate the function of this intronic microRNA and its role in carcinogenesis. +lncRNA target 32764349 hsa-mir-449 Darier Disease The DE candidate miRNAs, including miR-146a, miR-146b, miR-205a, miR-205b and miR-449, can be investigated further for functional validation studies and to be used as novel prophylactic and therapeutic targets in tailoring or enhancing antiviral responses against AIV. +lncRNA target 32764349 hsa-mir-205a Darier Disease The DE candidate miRNAs, including miR-146a, miR-146b, miR-205a, miR-205b and miR-449, can be investigated further for functional validation studies and to be used as novel prophylactic and therapeutic targets in tailoring or enhancing antiviral responses against AIV. +lncRNA target 32764349 hsa-mir-146b Darier Disease The DE candidate miRNAs, including miR-146a, miR-146b, miR-205a, miR-205b and miR-449, can be investigated further for functional validation studies and to be used as novel prophylactic and therapeutic targets in tailoring or enhancing antiviral responses against AIV. +lncRNA target 32764349 hsa-mir-205b Darier Disease The DE candidate miRNAs, including miR-146a, miR-146b, miR-205a, miR-205b and miR-449, can be investigated further for functional validation studies and to be used as novel prophylactic and therapeutic targets in tailoring or enhancing antiviral responses against AIV. +lncRNA target 32764349 hsa-mir-146a Darier Disease The DE candidate miRNAs, including miR-146a, miR-146b, miR-205a, miR-205b and miR-449, can be investigated further for functional validation studies and to be used as novel prophylactic and therapeutic targets in tailoring or enhancing antiviral responses against AIV. +circulation_biomarker_diagnosis_ns 32764335 hsa-mir-223 Kidney Failure, Chronic The uromodulin concentration and expression of six selected miRNAs (miR-29c, miR-126, miR-146a, miR-150, miR-155, and miR-223) were determined in the serum of 100 KTRs with stable graft function and chronic kidney disease of all five stages. +circulation_biomarker_diagnosis_ns 32764335 hsa-mir-126 Kidney Failure, Chronic The uromodulin concentration and expression of six selected miRNAs (miR-29c, miR-126, miR-146a, miR-150, miR-155, and miR-223) were determined in the serum of 100 KTRs with stable graft function and chronic kidney disease of all five stages. +circulation_biomarker_diagnosis_ns 32764335 hsa-mir-29c Kidney Failure, Chronic The uromodulin concentration and expression of six selected miRNAs (miR-29c, miR-126, miR-146a, miR-150, miR-155, and miR-223) were determined in the serum of 100 KTRs with stable graft function and chronic kidney disease of all five stages. +circulation_biomarker_diagnosis_ns 32764335 hsa-mir-146a Kidney Failure, Chronic The uromodulin concentration and expression of six selected miRNAs (miR-29c, miR-126, miR-146a, miR-150, miR-155, and miR-223) were determined in the serum of 100 KTRs with stable graft function and chronic kidney disease of all five stages. +circulation_biomarker_diagnosis_ns 32764335 hsa-mir-155 Kidney Failure, Chronic The uromodulin concentration and expression of six selected miRNAs (miR-29c, miR-126, miR-146a, miR-150, miR-155, and miR-223) were determined in the serum of 100 KTRs with stable graft function and chronic kidney disease of all five stages. +circulation_biomarker_diagnosis_ns 32764335 hsa-mir-150 Kidney Failure, Chronic The uromodulin concentration and expression of six selected miRNAs (miR-29c, miR-126, miR-146a, miR-150, miR-155, and miR-223) were determined in the serum of 100 KTRs with stable graft function and chronic kidney disease of all five stages. +other 32763781 hsa-mir-29a Stomach Neoplasms The experimental results revealed that the H19-miR-29a-3p-COL1A2 axis may promote macrophage polarization from M1 to M2 in GC. +lncRNA target 32763778 hsa-mir-378 Squamous Cell Carcinoma of Head and Neck Mechanistically, HOXC13-AS upregulated HOXC13 expression in OSCC through sequestering miR-378g, which was proved to exert suppressive functions in the malignant behaviors of OSCC cells. +other 32763656 hsa-mir-211 Epilepsy Considering that animal studies have shown that dynamic changes and the decreased levels of microRNA-211 contribute to epileptic seizures and to changes in cholinergic pathways, our hypothesis is that epileptic seizures and the development of epileptogenesis in SHE are a consequence of cholinergic dysfunction and decreased levels of microRNA-211 as opposed to NREM parasomnias where there is a stable level of microRNA-211, preventing epileptogenesis despite the cholinergic system dysfunction. +genetics_overexpression_promote 32763246 hsa-mir-184 Carcinoma, Hepatocellular "The inhibitory effects of MHCC97H cells resulted from abnormal XPO5 SUMO modification could be blocked by miR-3184 inhibitor or PLCB1 overexpression. In conclusion, our findings demonstrate a novel mechanism of XPO5 in HCC, that is, the SUMOylated XPO5 acts as an ""oncogenic"" role in MHCC97H cells proliferation, migration and invasion by controlling the nuclear-cytoplasm transportation of miR-3184, thus up-regulating PLCB1 expression." +other 32763196 hsa-mir-34a Liver Cirrhosis FINDINGS The derived NIS4 algorithm comprised four independent NASH-associated biomarkers (miR-34a-5p, alpha-2 macroglobulin, YKL-40, and glycated haemoglobin; area under the receiver operating characteristics curve [AUROC] 080, 95% CI 073-085), and did not require adjustment for age, sex, body-mass index (BMI), or aminotransferase concentrations. +other 32763196 hsa-mir-34a non-alcoholic steatohepatitis FINDINGS The derived NIS4 algorithm comprised four independent NASH-associated biomarkers (miR-34a-5p, alpha-2 macroglobulin, YKL-40, and glycated haemoglobin; area under the receiver operating characteristics curve [AUROC] 080, 95% CI 073-085), and did not require adjustment for age, sex, body-mass index (BMI), or aminotransferase concentrations. +transcription factor target 32763157 hsa-mir-126 Liver Failure Our findings suggest the potential role of miR-126 as a nucleic acid therapy drug target for liver failure. +transcription factor target 32763157 hsa-mir-126 Chemical and Drug Induced Liver Injury These findings revealed the role of miR-126 in regulating SOX9(+) LPCs fate by targeting Hoxb6 in liver injury repair. +circulation_biomarker_diagnosis_down 32762552 hsa-mir-135a Heart Failure The levels of miR-135a and miR-135b were downregulated in the plasma of patients with CHF. Conclusion: CDR1as is a potential biomarker of CHF that is mechanistically involved in the disease pathogenesis and participates in regulating the occurrence and development of CHF through the miR-135a/HMOX1 and miR-135b/HMOX1 signaling axes. +circulation_biomarker_diagnosis_down 32762552 hsa-mir-135b Heart Failure The levels of miR-135a and miR-135b were downregulated in the plasma of patients with CHF. Conclusion: CDR1as is a potential biomarker of CHF that is mechanistically involved in the disease pathogenesis and participates in regulating the occurrence and development of CHF through the miR-135a/HMOX1 and miR-135b/HMOX1 signaling axes. +genetics_overexpression_suppress 32762546 hsa-mir-524 Glioma 5p on the malignancy of glioma cells was overturned by overexpression of RAB5A. +circulation_biomarker_prognosis_ns 32762227 hsa-mir-214 Carcinoma, Hepatocellular BACKGROUND The purpose of this study is to evaluate the expression of tumor-specific growth factor (TSGF) and microRNA-214 (miR-214) in the serum of patients with primary hepatocellular carcinoma (PHC) and their predictive values for the curative effect of transcatheter arterial chemoembolization (TACE). CONCLUSIONS Serum TSGF and miR-214 could be used as potential biomarkers for PHC diagnosis and prognosis. +lncRNA target 32762066 hsa-mir-498 Periodontitis CONCLUSION: Therefore, TUG1 could protect against periodontitis via regulating miR-498/RORA mediated Wnt/beta-catenin signaling. +lncRNA target 32762035 hsa-mir-4701 Adenocarcinoma of Lung Conclusively, our study demonstrated that SLCO4A1-AS1 facilitated cell growth and enhanced the resistance of LUAD cells to chemotherapy via activating WNT pathway through miR5p/NFE2L1 axis. +lncRNA target 32761843 hsa-mir-130b Spinal Cord Injuries As a conclusion, GRb1 alleviated SCI through reducing activated microglia-induced neuronal injury via miR-130b-5p/TLR4/NF-kappaB axis, providing a deep insight into the molecular basis of GRb1 in the treatment of SCI. +other 32761798 hsa-mir-146a Immune System Diseases However, the majority of studies focus on understanding how miRNA-146a regulates immune cells and the associated immune-based disorders. +other 32761798 hsa-mir-146a Inflammation As one of the first miRNAs identified that regulate innate immune responses, miR-146a has been reported to serve as a negative-feedback regulator in several chronic inflammatory diseases. +genetics_overexpression_suppress 32760272 hsa-mir-185 Polycystic Ovary Syndrome The results showed that miR-185 overexpression improved insulin level alteration and ovarian histological lesion in PCOS rats. +genetics_GWAS 32760225 hsa-mir-24 Uterine Cervical Neoplasms 3p and DACT1 were predicted by LncBASE and Targetscan respectively, which were further verified by dual-luciferase reporter assay, RNA pull-down and point mutation; the relationship between genes was analyzed by Pearson correlation; the rescue experiments were used to further explore the involved molecular mechanism. +target gene 32760224 hsa-mir-361 Uterine Cervical Neoplasms Circular RNA UBAP2 contributes to tumor growth and metastasis of cervical cancer via modulating miR-361-3p/SOX4 axis. +target gene 32760222 hsa-mir-203 Esophageal Neoplasms Targeting deubiquitinating enzyme USP26 by microRNA-203 regulates Snail1's pro-metastatic functions in esophageal cancer. +target gene 32760218 hsa-mir-29 Colorectal Neoplasms Long non-coding RNA KCNQ1OT1 up-regulates CTNND1 by sponging miR-329-3p to induce the proliferation, migration, invasion, and inhibit apoptosis of colorectal cancer cells. +lncRNA target 32760216 hsa-mir-17 Carcinoma, Renal Cell CONCLUSION: HOTAIR negatively targets miR +circulation_biomarker_diagnosis_ns 32759718 hsa-mir-29a Colorectal Neoplasms In preoperative plasma, there were significant differences in CRC with stage >/= III (MIR29a) and perineural invasion (MIR21). +circulation_biomarker_diagnosis_ns 32759718 hsa-mir-21 Colorectal Neoplasms In preoperative plasma, there were significant differences in CRC with stage >/= III (MIR29a) and perineural invasion (MIR21). +circulation_biomarker_diagnosis_up 32759383 hsa-mir-142 Diabetic Nephropathies 3p was significantly upregulated in sputum and plasma of patients with IPF (8.06-fold, p<0.0001; 1.64 fold, p=0.008, respectively). +virus_miRNA 32759334 hcmv-mir-US5-2 Human Cytomegalovirus Infections miR-US5-2, through downregulation of GAB1, could play a critical role during reactivation from latency by reducing proliferation and UL138 expression. +other 32758717 hsa-mir-135a Pre-Eclampsia RESULTS: We found that miR-135a-5p expression was significantly decreased and negatively correlated with beta-TrCP expression in the placental tissues of pregnant women with PE. +genetics_overexpression_promote 32758622 hsa-mir-133a Stomach Neoplasms Notably, the promoting effects of overexpressed miR-133a-3p on Bufothionine-induced GC cell death were abrogated by overexpressing IGF1R, and aggravated by the PI3K/Akt cascade inhibitor (LY294002). SIGNIFICANCE: Bufothionine promoted GC cell death by triggering miR-133a-3p/IGF1R/PI3K/Akt axis mediated ER stress and ROS production. +transcription factor target 32758616 hsa-mir-204 Breast Neoplasms We report that miR-204 can target and inhibit the expression of COX5A, thus, reversing the functions of COX5A in ER breast cancer cells. +lncRNA target 32758486 hsa-mir-342 Lung Injury Finally, a rat model was developed to evaluate the effects of HDAC2, miR-342 and Kruppel-like factor 5 (KLF5) on PQ-induced lung injury in vivo. CONCLUSION: PQ treatment inhibited miR-342 expression by promoting HDAC2-induced deacetylation of the FoxF1 promoter, thereby promoting KLF5 expression and the IkappaB/NF-kappaB p65 signaling activation, and finally exacerbating PQ-induced lung injury in rats. +genetics_knock down_suppress 32758099 hsa-mir-181a Diabetes Mellitus Taken together, these findings demonstrated that PVT1-knockdown could ameliorate STZ-induced oxidative stress and apoptosis and elevate insulin secretory capacity in pancreatic beta cells by regulating miR-181a-5p, suggesting a promising biomarker in DM diagnosis and treatment. +genetics_overexpression_promote 32758011 hsa-mir-188 Squamous Cell Carcinoma of Head and Neck 3p inhibitor and ABCB1 overexpression also could invert the suppression effect of circ_0109291 silencing on the DDP resistance of OSCC cells. +genetics_knock down_promote 32757994 hsa-mir-21 Carcinoma, Hepatocellular 5p, and knockdown of SOX6 overturned curcumin-modulated suppression of HCC progression. +other 32757734 hsa-mir-155 Breast Neoplasms MicroRNA-155 (miR-155) has emerged as a typical multifunctional gene regulator associated with immune system development and immune cell activation and differentiation.Methods: In this study, a three-dimensional TME model that closely mimics the microenvironment of breast cancer was prepared. +lncRNA target 32757684 hsa-mir-340 Retinoblastoma MATERIALS AND METHODS: miR-340 mimic and inhibitor were applied for up-regulating or inhibiting the expression of miR-340 in RB cell lines. +lncRNA target 32757663 hsa-mir-106a Osteosarcoma These data suggested that HOTAIR enhanced DDP resistance of Saos2/DDP, MG-63/DDP, and U2OS/DDP cells by affecting cell proliferation, invasion, and apoptosis via miR-106a-5p/STAT3 axis. +genetics_overexpression_suppress 32757457 hsa-mir-24 Uterine Cervical Neoplasms 5p overexpression affects the radiotherapy response of CC by targeting ELAVL1, which may serve as a new target for the treatment of CC. +lncRNA target 32757174 hsa-mir-497 Colorectal Neoplasms In conclusion, KCNQ1OT1 aggravated cisplatin resistance in CRC cells via the miR-497/Bcl-2 axis. +lncRNA target 32757169 hsa-mir-339 Intestinal Diseases OBJECTIVE: The objective of this study is to evaluate the miR-339 function in regulating intestinal epithelial cells to defend against bacterial infection through biological experiments and bioinformatics analyses. RESULTS: miR-339 attenuates LPS-induced intestinal epithelial cells inflammatory responses through the TLR4/NF-kappaB signaling pathway and inhibited LPS-induced apoptosis through the P53 signaling pathway. +lncRNA target 32757096 hsa-mir-1469 Pancreatic Carcinoma 5p inhibitor in pancreatic cancer cells. +other 32757043 hsa-mir-585 Polycystic Ovary Syndrome 5p was downregulated in the ovaries of PCOS with insulin resistance rats compared with the controls. +other 32757043 hsa-mir-146 Polycystic Ovary Syndrome 5p was downregulated in the ovaries of PCOS with insulin resistance rats compared with the controls. +lncRNA target 32756923 hsa-mir-222 Retinoblastoma CONCLUSIONS: miR-222 promotes the expression of HIF1alpha by targeting VHL, thus accelerating the resistance of RB cells to the chemotherapeutic agent VCR. +lncRNA target 32756923 hsa-mir-222 von Hippel-Lindau Disease CONCLUSIONS: miR-222 promotes the expression of HIF1alpha by targeting VHL, thus accelerating the resistance of RB cells to the chemotherapeutic agent VCR. +other 32756589 hsa-mir-155 Diabetes Mellitus miRNA-155 was the most reliable predictors of periodontitis among non-diabetics with an optimum cut-off value of < 8.97 with accuracy = 82.6%. The results of the present study concluded that MiRNA-146a and miRNA155 in saliva provide reliable, non-invasive, diagnostic and prognostic biomarkers that can be used to monitor periodontal health status among diabetic and non-diabetic patients. +other 32756589 hsa-mir-155 Periodontitis miRNA-155 was the most reliable predictors of periodontitis among non-diabetics with an optimum cut-off value of < 8.97 with accuracy = 82.6%. The results of the present study concluded that MiRNA-146a and miRNA155 in saliva provide reliable, non-invasive, diagnostic and prognostic biomarkers that can be used to monitor periodontal health status among diabetic and non-diabetic patients. +exosome 32756532 hsa-mir-200a Breast Neoplasms MiR-200a-3p was a target of circ_UBE2D2, and we demonstrated that exosomes mediated transfer of circ_UBE2D2 interacted with miR-200a-3p to enhance tamoxifen resistance of breast cancer cells by regulating cell viability, metastasis, and the level of ERalpha in vivo and in vitro. CONCLUSIONS Exosomes mediated transfer of circ_UBE2D2 reinforced tamoxifen resistance in breast cancer by binding to miR-200a-3p, providing new insights into the boost of the effectiveness of tamoxifen on breast cancer patients. +lncRNA target 32756097 hsa-mir-423 Intracranial Aneurysm 3p were proven to be valuable in prediction IA occurrence.In a word, this study reveals hub miRNAs, target genes and pathways potentially participating in formation and development of IA and screens out some candidate biomarkers. +lncRNA target 32756097 hsa-mir-424 Intracranial Aneurysm 3p were proven to be valuable in prediction IA occurrence.In a word, this study reveals hub miRNAs, target genes and pathways potentially participating in formation and development of IA and screens out some candidate biomarkers. +lncRNA target 32756097 hsa-mir-191 Intracranial Aneurysm 3p were proven to be valuable in prediction IA occurrence.In a word, this study reveals hub miRNAs, target genes and pathways potentially participating in formation and development of IA and screens out some candidate biomarkers. +lncRNA target 32756011 hsa-mir-195 Urinary Bladder Neoplasms Our study demonstrated that DLX6-AS1 played an oncogenic role in BC through miR +other 32756009 hsa-mir-145 Breast Neoplasms circIQCH sponges miR-145 to promote breast cancer progression by upregulating DNMT3A expression. +genetics_overexpression_promote 32756006 hsa-mir-21 Brain Injuries 3p) were overexpressed in all enrolled groups. +genetics_overexpression_promote 32756006 hsa-mir-124 Brain Injuries 3p) were overexpressed in all enrolled groups. +genetics_overexpression_promote 32756006 hsa-mir-144 Brain Injuries 3p) were overexpressed in all enrolled groups. +genetics_overexpression_promote 32756006 hsa-mir-34a Brain Injuries 3p) were overexpressed in all enrolled groups. +genetics_overexpression_promote 32756006 hsa-mir-132 Brain Injuries 3p) were overexpressed in all enrolled groups. +transcription factor target 32755834 hsa-mir-34a Obesity In this work, we hypothesized that elevated levels of miR-34a in overweight/obese group inhibits Sirt1 activity. miR-34a expression increased in the overweight/obese group compared to normoweight individuals. +lncRNA target 32755793 hsa-mir-204 Cholangiocarcinoma CONCLUSION: These data unraveled that lncRNA HOTAIR regulated HMGB1 to suppress cell apoptosis, autophagy and induce cell proliferation by sponging miR +genetics_overexpression_promote 32755726 hsa-mir-3666 Fatty Liver Overexpression of miR-3666 in these cells decreased the extent of hepatic steatosis. +genetics_knock down_promote 32755451 hsa-mir-140 Pulmonary Fibrosis In conclusion, the key findings from our study suggest that overexpressed miR-140 suppresses ILD development via the Wnt signaling pathway by downregulating OGN, which could potentially be used as a therapeutic target for ILD. +genetics_knock down_promote 32755451 hsa-mir-140 Lung Diseases, Interstitial In conclusion, the key findings from our study suggest that overexpressed miR-140 suppresses ILD development via the Wnt signaling pathway by downregulating OGN, which could potentially be used as a therapeutic target for ILD. +genetics_knock down_suppress 32755283 hsa-mir-18a Intracranial Arteriovenous Malformations METHODS AND RESULTS: The molecular pathways affected by miR-18a in patient-derived BECs and AVM-BECs were determined by Western blot, RT-qPCR (quantitative reverse transcription polymerase chain reaction), ELISA, co-IP, immunostaining, knockdown and overexpression studies, flow cytometry, and luciferase reporter assays. +exosome 32754983 hsa-mir-206 Muscular Dystrophy, Duchenne AntagomiR-mediated blockade of individual miRs reveals a specific requirement of miR-206 for EV-induced expansion of MuSCs and regeneration of dystrophic muscles, and indicates that cooperative activity of HDACi-induced miRs accounts for the net biological effect of these EVs. +genetics_overexpression_promote 32754978 hsa-mir-205 Precursor Cell Lymphoblastic Leukemia-Lymphoma Moreover, MALAT1 silencing or miR-205 overexpression restrained proliferation and promoted apoptosis of ALL cells. +transcription factor target 32754856 hsa-mir-506 Burns 3p regulated autophagy and proliferation in post-burn skin fibroblasts through post-transcriptionally suppressing Beclin-1 expression. +genetics_overexpression_promote 32754282 hsa-mir-378a Carcinoma, Hepatocellular miR-378a-3p overexpression induced apoptosis in SR HCC cells, whereas miR-378a-3p silencing exerted the opposite effects. +other 32754277 hsa-mir-146b Triple Negative Breast Neoplasms 5p and miR-20a-5p), an accurate predictive model of relapse in TNBC patients was established and was highly correlated with prognosis (AUC of 0.80). +other 32754277 hsa-mir-10b Triple Negative Breast Neoplasms 5p and miR-20a-5p), an accurate predictive model of relapse in TNBC patients was established and was highly correlated with prognosis (AUC of 0.80). +other 32754277 hsa-mir-20a Triple Negative Breast Neoplasms 5p and miR-20a-5p), an accurate predictive model of relapse in TNBC patients was established and was highly correlated with prognosis (AUC of 0.80). +other 32754277 hsa-mir-486 Triple Negative Breast Neoplasms 5p and miR-20a-5p), an accurate predictive model of relapse in TNBC patients was established and was highly correlated with prognosis (AUC of 0.80). +other 32754277 hsa-mir-139 Triple Negative Breast Neoplasms 5p and miR-20a-5p), an accurate predictive model of relapse in TNBC patients was established and was highly correlated with prognosis (AUC of 0.80). +other 32754270 hsa-mir-632 Kidney Failure, Chronic miR5p and miR-632 entered the tree by redefining two risk groups: patients older than 64 years and with hsCRP<0.827 mg/L and diabetic patients younger than 64 years. +other 32754270 hsa-mir-186 Kidney Failure, Chronic miR5p and miR-632 entered the tree by redefining two risk groups: patients older than 64 years and with hsCRP<0.827 mg/L and diabetic patients younger than 64 years. +genetics_GWAS 32754259 hsa-mir-29b Breast Neoplasms Conclusions: Our findings identified EZH2-miR-29b/miR-30d-LOXL4 signaling pathway was involved in breast tumorigenesis, and suggested that the epigenetic modulation represents a potential therapeutic target for breast cancer by controlling macrophage activation. +other 32754258 hsa-mir-365 Osteoarthritis, Post-Traumatic After NPs-YCWP therapy, the results of histological staining, gene and protein expression showed that miR365 antagomir/NPs-YCWP improved the symptom of PTOA. +genetics_overexpression_suppress 32753971 hsa-mir-27a Stomach Neoplasms The transfection of miR-27a-3p mimics reversed the inhibitory effects on proliferative and metastatic abilities of GC cells with LINC01089 overexpression. CONCLUSION: LINC01089 inhibits cell proliferation and metastasis in GC by targeting miR-27a-3p/EMT axis, which should be considered as a promising therapeutic target. +other 32753970 hsa-mir-214 Osteosarcoma CONCLUSION: LINC01535, miR3p and KCNC4 constituted an effective axis that exerted a pregnant regulation in OS development, which is a quite meaningful discovery for exploring potential therapeutic methods for OS patients. +lncRNA target 32753969 hsa-mir-577 Carcinoma, Non-Small-Cell Lung CONCLUSION: Circ_0016760 silencing impeded NSCLC advancement through regulation of the miR-577/ZBTB7A axis. +lncRNA target 32753964 hsa-mir-195 Carcinoma, Non-Small-Cell Lung 5p, and glucose transporter member 3 (GLUT3) was shown to be a target gene of miR +transcription factor target 32753959 hsa-mir-22 Colorectal Neoplasms CONCLUSION: miR-22 suppresses cell proliferation, migration, and invasion in colorectal cancer by targeting NLRP3. +target gene 32753949 hsa-mir-21 Glioblastoma PWRN1 Suppressed Cancer Cell Proliferation and Migration in Glioblastoma by Inversely Regulating hsa-miR-21-5p. +genetics_overexpression_promote 32753947 hsa-mir-221 Squamous Cell Carcinoma of Head and Neck In addition, overexpression of NR4A1AS or miR-221 increased the proliferation rate of OSCC cells. +exosome 32753931 hsa-mir-21 Tendinopathy The antagonist targeting miR-21a-3p was recruited for treatment of HUMSCs, and harvested HUMSC-Exos, which expressed low levels of miR-21a-3p, and expanded the inhibition of tendon adhesion in subsequent in vitro experiments. CONCLUSION: Our results indicate that HUMSC-Exos may manipulate p65 activity by delivering low-abundance miR-21a-3p, ultimately inhibiting tendon adhesion. +exosome 32753931 hsa-mir-21 Tissue Adhesions The antagonist targeting miR-21a-3p was recruited for treatment of HUMSCs, and harvested HUMSC-Exos, which expressed low levels of miR-21a-3p, and expanded the inhibition of tendon adhesion in subsequent in vitro experiments. CONCLUSION: Our results indicate that HUMSC-Exos may manipulate p65 activity by delivering low-abundance miR-21a-3p, ultimately inhibiting tendon adhesion. +target gene 32753899 hsa-mir-542 Breast Neoplasms Pristimerin Suppressed Breast Cancer Progression via miR-542-5p/DUB3 Axis. +circulation_biomarker_diagnosis_ns 32753892 hsa-mir-20a Carcinoma, Hepatocellular MATERIALS AND METHODS: The expressions of TMPO-AS1 and miR-320a were detected in HCC tissues and cells by qRT-RCR. Further studies revealed that lncRNA TMPO-AS1 was largely located in the cytoplasm of HCC cell and sponge miR-320a, resulting in increasing the level of SERBP1 in HCC cell. +lncRNA target 32753887 hsa-mir-195 Liposarcoma CONCLUSION: miR-195 suppressed cell growth, migration and elevated cell apoptosis via OSBP in liposarcoma. +lncRNA target 32753848 hsa-let-7 Sciatic Neuropathy CONCLUSION: UTI modulates the let-7/NGF axis to inhibit oxidative stress, promote nerve regeneration, and facilitate function recovery after peripheral nerve injury. +lncRNA target 32753846 hsa-mir-766 Osteoarthritis induced apoptosis and the degradation of ECM through activating autophagy via miR +genetics_knock down_promote 32753631 hsa-mir-149 Carcinoma, Hepatocellular Knockdown of KCNQ1OT1 or overexpression of miR-149 inhibited the invasion and migration of HCC cells. +lncRNA target 32753611 hsa-mir-4634 Carcinoma, Non-Small-Cell Lung In conclusion, miR-4634 may act as a tumor suppressor in NSCLC, and to augment the efficacy of RAD001, co-treatment of miR-4634 and RAD001 might be a potential mTOR-targeted cancer therapy strategy for NSCLC patients. +lncRNA target 32753405 hsa-mir-635 Stomach Neoplasms miR-635 can target KIFC1 to inhibit proliferation, migration and invasion of GC cells. +other 32753014 hsa-let-7b Carcinoma, Non-Small-Cell Lung Chloroquine Assisted Delivery of microRNA Mimic Let-7b to NSCLC Cell Line by PAMAM (G5) - HA Nano-Carrier. PURPOSE The purpose of this study is to investigate the anti-tumor effect of microRNA Mimic let-7b loaded in PAMAM dendrimers (G5) on Non-Small Cell Lung Cancer (NSCLC) cells. +circulation_biomarker_diagnosis_ns 32752917 hsa-mir-92a Diabetes Mellitus MiRNAs previously shown to be associated with diabetes (Let-7a, Let-7e, miR-144 and miR-92a) were extracted from serum pre- and post-intervention. +circulation_biomarker_diagnosis_ns 32752917 hsa-mir-144 Diabetes Mellitus MiRNAs previously shown to be associated with diabetes (Let-7a, Let-7e, miR-144 and miR-92a) were extracted from serum pre- and post-intervention. +circulation_biomarker_diagnosis_ns 32752917 hsa-let-7e Diabetes Mellitus MiRNAs previously shown to be associated with diabetes (Let-7a, Let-7e, miR-144 and miR-92a) were extracted from serum pre- and post-intervention. +circulation_biomarker_diagnosis_ns 32752917 hsa-let-7a Diabetes Mellitus MiRNAs previously shown to be associated with diabetes (Let-7a, Let-7e, miR-144 and miR-92a) were extracted from serum pre- and post-intervention. +transcription factor target 32752071 hsa-mir-449a Nasopharyngeal Carcinoma mediated inhibition of NPC cell migration and growth of the tumor spheres. +lncRNA target 32751711 hsa-mir-221 Breast Neoplasms miR3p, known to target PTEN and cell cycle regulators, also targets RSU1 and PINCH1 in luminal breast cancer cell lines. +other 32751663 hsa-mir-365 Budd-Chiari Syndrome 5p was downregulated in HCV BD and miR-221 was downregulated in HCV patients and BDs. +other 32751663 hsa-mir-627 Budd-Chiari Syndrome 5p was downregulated in HCV BD and miR-221 was downregulated in HCV patients and BDs. +other 32751663 hsa-mir-526b Hepatitis E In HEV infection, miR-526b appeared specifically downregulated. +other 32751663 hsa-mir-885 Budd-Chiari Syndrome 5p was downregulated in HCV BD and miR-221 was downregulated in HCV patients and BDs. +other 32751663 hsa-mir-885 Hepatitis C 5p was downregulated in HCV BD and miR-221 was downregulated in HCV patients and BDs. +other 32751663 hsa-mir-365 Hepatitis C 5p was downregulated in HCV BD and miR-221 was downregulated in HCV patients and BDs. +other 32751663 hsa-mir-221 Budd-Chiari Syndrome 5p was downregulated in HCV BD and miR-221 was downregulated in HCV patients and BDs. +other 32751663 hsa-mir-221 Hepatitis C 5p was downregulated in HCV BD and miR-221 was downregulated in HCV patients and BDs. +other 32751663 hsa-mir-627 Hepatitis C 5p was downregulated in HCV BD and miR-221 was downregulated in HCV patients and BDs. +other 32751105 hsa-mir-423 Brain Injuries, Traumatic 3p could represent a promising new biomarker to identify severe isolated TBI. +other 32750152 hsa-mir-514a Cholangiocarcinoma For CCA cells, circ-CCAC1 increased cell progression by sponging miR-514a-5p to up-regulate Yin Yang 1 (YY1). +genetics_overexpression_promote 32749850 hsa-mir-342 Carcinoma, Non-Small-Cell Lung miR-342 overexpression hindered the migration, invasion and cell cycle progression, and accelerated the apoptosis of NSCLC cells. +genetics_overexpression_promote 32749849 hsa-mir-138 Squamous Cell Carcinoma of Head and Neck 5p overexpression could reverse the promotion effect of overexpressed UCA1 on TSCC progression. +genetics_knock down_promote 32749848 hsa-mir-103a Thyroid Neoplasms Taken together, knockdown of miR-103a-3p inhibits proliferation, migration, and invasion and promotes apoptosis of thyroid cancer cells through the Hippo signaling pathway by upregulating LATS1. +lncRNA target 32749762 hsa-mir-664a Osteosarcoma In one of our previous studies, we showed that lncRNA MEG3 is being regulated by microRNA-664a (miR-664a) suppresses the migratory potential of osteosarcoma cells (U-2OS). +genetics_overexpression_promote 32749750 hsa-mir-587 Uterine Cervical Neoplasms We also discovered that the antineoplastic properties of IRF6 could be reversed by overexpressing miR-587 in cervical cancer cells. +lncRNA target 32749665 hsa-mir-590 Ovarian Neoplasms Taken together, lncRNA DUXAP8 can regulate the proliferation and apoptosis of ovarian cancer cells, and its mechanism may be related to the regulation of YAP1 gene by targeting miR +transcription factor target 32749639 hsa-mir-137 Colorectal Neoplasms 3p inhibits CRC cell migration by regulating a KDM1A-dependent EMT process. +lncRNA target 32749120 hsa-mir-195 Colorectal Neoplasms NEAT1 promotes colorectal cancer cellular processes by regulating CEP55 expression via the sponging of miR +other 32749107 hsa-mir-21 Respiratory Tract Neoplasms Furthermore, subgroup analysis demonstrates that high miR-21 expression is related to shorter OS in patients with digestive system cancers (HR = 1.02; 95% CI, 1.002 to 1.04; p = 0.026), respiratory system cancers (HR = 1.93; 95% CI, 1.48 to 2.51; p < 0.001), and breast cancer (HR = 2.20; 95% CI, 1.78 to 2.73; p = 0.001). +other 32749107 hsa-mir-21 Digestive System Neoplasms Furthermore, subgroup analysis demonstrates that high miR-21 expression is related to shorter OS in patients with digestive system cancers (HR = 1.02; 95% CI, 1.002 to 1.04; p = 0.026), respiratory system cancers (HR = 1.93; 95% CI, 1.48 to 2.51; p < 0.001), and breast cancer (HR = 2.20; 95% CI, 1.78 to 2.73; p = 0.001). +other 32749107 hsa-mir-21 Breast Neoplasms Furthermore, subgroup analysis demonstrates that high miR-21 expression is related to shorter OS in patients with digestive system cancers (HR = 1.02; 95% CI, 1.002 to 1.04; p = 0.026), respiratory system cancers (HR = 1.93; 95% CI, 1.48 to 2.51; p < 0.001), and breast cancer (HR = 2.20; 95% CI, 1.78 to 2.73; p = 0.001). +genetics_GWAS 32748943 hsa-mir-17 Liver Neoplasms To assess whether the MIR17HG polymorphisms are associated with the liver cancer risk in the Chinese Han population, we performed a case-control (432 liver cancer patients and 430 healthy controls) study. Our findings indicated that MIR17HG polymorphism (rs7318578) contributes to liver cancer susceptibility to the Chinese Han population. +other 32748760 hsa-let-7f Colonic Neoplasms The present study aimed to uncover the function of let-7f-5p in the proliferation of human colon cancer cell line Caco2 and explored chemopreventive agents from natural resources that can prevent the development of CRC. +lncRNA target 32748760 hsa-let-7f Colorectal Neoplasms CONCLUSION: Our validation study results confirmed that let-7f-5p was a potent tumor suppressor gene of Caco2 cell proliferation, and RA showed as a regulator of the effect of let-7f-5p on cell proliferation and then could be a potential chemopreventive agent for CRC treatment. +circulation_biomarker_diagnosis_ns 32748386 hsa-mir-122 Heroin Dependence The aim of this study was to concomitantly examine the levels of protamine-2 gene and protein concentrations, the amount of miRNA-122 in seminal plasma and semen analysis findings in heroin-addicted men. Seminal miRNA-122 levels in addicted men (3.51+/-0.73) were statistically higher than in healthy men (1.52+/-0.54) (p=0.034). +transcription factor target 32748313 hsa-mir-224 McDonough syndrome These results indicate that the aberrant expression of miRNA5p and its target genes is involved in the impaired osteoblast differentiation and may provide a partial molecular explanation for the pathogenesis of congenital scoliosis. +genetics_overexpression_promote 32748275 hsa-mir-126 Inflammation After overexpression of miR-126, the release of TNF-alpha, IL-6, and IL-17 decreased; the release of IL-10 increased; T lymphocyte subsets differentiated toward Treg; caspase signaling pathway weakened; and lymphocyte of apoptosis decreased compared with sepsis group. +genetics_overexpression_promote 32748275 hsa-mir-126 Sepsis After overexpression of miR-126, the release of TNF-alpha, IL-6, and IL-17 decreased; the release of IL-10 increased; T lymphocyte subsets differentiated toward Treg; caspase signaling pathway weakened; and lymphocyte of apoptosis decreased compared with sepsis group. +lncRNA target 32748220 hsa-mir-34a Carcinoma, Endometrioid miR-34a was proved to be a tumor suppressor in different malignance, hence downregulating Lnc-OC1 helped to alleviate EC by releasing miR-34a. Concisely, our results proved that Lnc-OC1/miR-34a/PD-L1 axis might serve as a therapeutic target of EC. +lncRNA target 32747644 hsa-mir-150 Lung Injury In conclusion, sacubitril/valsartan effectively abrogated the CP induced lung inflammation and fibrosis, providing a potential promising protection that could be linked to their ability to inhibit miR3p via inhibition of NF-kappaB and MAPK signaling pathways. +lncRNA target 32747423 hsa-let-7 Adenoma, Islet Cell CDK6 was one of the most downregulated targets of both let-7 and miR21 in mTOR KD tumors. +lncRNA target 32747423 hsa-mir-21 Adenoma, Islet Cell CDK6 was one of the most downregulated targets of both let-7 and miR21 in mTOR KD tumors. +genetics_overexpression_promote 32747087 hsa-mir-524 Osteosarcoma Overexpressed CDK6 was found in OS tissues, which was inversely correlated with that of miR +lncRNA target 32746998 hsa-let-7c Adenocarcinoma of Lung Collectively, hsa-let-7c shows an anti-tumor effect in lung adenocarcinoma by targeting ANP32E and is expected to be a potential therapeutic target for lung adenocarcinoma. +genetics_overexpression_promote 32746985 hsa-mir-21 Colorectal Neoplasms Our results showed that miR-21 overexpression promoted MCTS formation through enhancing E-cadherin-dependent cell-cell interactions, which represents an advance in vitro model for investigating CRC biology. +transcription factor target 32746934 hsa-mir-148a Carcinoma, Hepatocellular Transwell, CCK8 and animal experiments exhibited miR-148a inhibited metastasis and proliferation of HCC in vitro and in vivo. +lncRNA target 32746878 hsa-let-7 Diabetes Mellitus, Type 2 CONCLUSION: Taken together, circ-CPA4 regulated cell growth, mobility, stemness and drug resistance in NSCLC cells and inactivated CD8(+) T cells in the tumor immune microenvironment through let-7 miRNA/PD-L1 axis. +lncRNA target 32746878 hsa-let-7 Carcinoma, Non-Small-Cell Lung CONCLUSION: Taken together, circ-CPA4 regulated cell growth, mobility, stemness and drug resistance in NSCLC cells and inactivated CD8(+) T cells in the tumor immune microenvironment through let-7 miRNA/PD-L1 axis. +transcription factor target 32746845 hsa-mir-29b Multiple Myeloma CONCLUSIONS: Collectively, our data suggest that Exo(C6-cer)-mediated miR-29b expression participates in the progression of MM through suppressing the proliferation, migration and angiogenesis of ECs by targeting Akt signal pathway. +other 32746603 hsa-mir-223 Cardiomyopathies Objective: To investigate the protective effect of microRNA 223 (miR-223) on cardiac fibrosis-related signaling pathway and its regulation on expression of Twist family basic helix-loop-helix transcription factor 1 (Twist1) and transforming growth factor-beta1 receptor 2 (TGFBR2) in rat cardiomyocytes. +transcription factor target 32745971 hsa-mir-15a Trypanosomiasis, African Pathway analysis of these 10 miRNAs indicated that targets of miR-15a-5p were significantly enriched in the HAT-related neurotrophin signaling pathway. +transcription factor target 32745469 hsa-mir-188 Stroke The study findings from in vitro investigations yielded promising results and provided excellent insights about the fundamental molecular mechanisms of miR5p involved in stroke via PTEN. +genetics_knock down_promote 32745381 hsa-mir-21 Epilepsy 5p can inhibit STAT3 expression and reduce apoptosis and loss of hippocampal neurons and IL-6 level, thereby achieving protective effects on hippocampal neurons of epileptic rats. +lncRNA target 32744697 hsa-mir-101 Osteosarcoma Furthermore, we found that DSCAM-AS1 inhibited miR-101 expression by direct interaction and DSCAM-AS1 promoted OS progression by sponging miR-101. CONCLUSIONS: The present study demonstrated that DSCAM-AS1 accelerated OS cell progression by sponging miR-101, which might provide a new sight in the treatment of OS. +lncRNA target 32744696 hsa-mir-223 Melanoma CONCLUSIONS: These findings therefore suggest that DBH-AS1 can enhance glycolytic activity in melanoma cells, thereby disrupting melanoma progression via miR +lncRNA target 32744694 hsa-mir-186 Glioma We propose that miR-186 can be used as a novel biomarker for glioma diagnosis in the future, or as a new pharmacy target in the cure of gliomas. +other 32744693 hsa-mir-193a Pituitary Neoplasms OBJECTIVE: Our study aimed to investigate miR-193a-3p expression and its clinical significance in pituitary adenomas (PAs). CONCLUSIONS: MiR-193a-3p could have potential therapeutic value for invasive pituitary adenomas. +lncRNA target 32744690 hsa-mir-219c Colorectal Neoplasms OBJECTIVE: To investigate the expression of Long non-coding RNA ADIPOQ and its facilitating effects on proliferation and invasion of colorectal cancer by modulating the expression of TP53 via sponging with miR-219c-3p. CONCLUSIONS: For the first time, we found that lncRNA-ADIPOQ was downregulated in human colorectal cancer cells, which could facilitate tumor proliferation, migration and invasion as a ceRNA by sponging with miR-219c-3p. +lncRNA target 32744689 hsa-mir-124 Colorectal Neoplasms Besides that, we preliminarily verified that FZD4 was a direct target gene of LINC00963/miR +lncRNA target 32744687 hsa-mir-1226 Carcinoma, Hepatocellular Rescue assays demonstrated that ZFPM2-AS1 promotes HCC cell proliferation and invasion through modulating miR-1226/ITGB1 axis. +lncRNA target 32744686 hsa-mir-26b Gallbladder Neoplasms CONCLUSIONS: Inhibition of LncRNA SNHG6 expression can upregulate miR-26b-5p mediated Hedgehog signaling pathway, affect epithelial-mesenchymal transition, proliferation and invasion of cells, so LncRNA SNHG6is hoped to be a latent therapeutic target for gallbladder carcinoma. +genetics_knock down_promote 32744323 hsa-mir-2682 Arthritis, Rheumatoid Knockdown of ZFAS1 led to the curbs of cell proliferation, inflammation, autophagy, and boost apoptosis in FLS-RA, while these effects were abolished via regaining miR +genetics_knock down_suppress 32744015 hsa-mir-193a Ovarian Neoplasms Methods: TargetScanHuman was used to analyze the match between miR-193a-5p and CDK14, and then miRNA assay was used to detect whether miR-193a-5p targeting CDK14; miR-193a-5p mimics overexpression or miR-193a-5p inhibitor knockdown in the case of low miR-193a-5p, the expression levels of CDK14, EMT-related proteins E-cadherin, vimentin, fibronectin and N-cadherin were detected by immunoblotting, and the proliferation of ovarian cancer cells OVAC was detected by CCK-8, and the cell viability of cancer cell OVAC was detected by MMT. +lncRNA target 32743904 hsa-mir-326 Osteosarcoma SP1/HDAC1 caused the transcriptional inhibition of miR-326 gene by promoting histone deacetylation; miR-326 deficiency conversely stimulated SMO/Hedgehog pathway that was responsible for the proliferation and metastasis of OS. +other 32743554 hsa-mir-375 Neuroendocrine Tumors Comparative analyses showed that miR-375 and miR-7 expression is substantially higher in NEN cases than non-NEN controls. +other 32743554 hsa-mir-7 Neuroendocrine Tumors Comparative analyses showed that miR-375 and miR-7 expression is substantially higher in NEN cases than non-NEN controls. +genetics_overexpression_promote 32742494 hsa-mir-619 Gallbladder Neoplasms 5p mimics repressed the GBC cell proliferation, migration, invasion and could be rescued by DGCR5 overexpression. +target gene 32742484 hsa-mir-154 Uterine Cervical Neoplasms MicroRNA-154-5p regulates the HPV16 E7-pRb pathway in Cervical Carcinogenesis by targeting CUL2. +circulation_biomarker_diagnosis_up 32742479 hsa-mir-941 Squamous Cell Carcinoma of Head and Neck In conclusion, serum exosomal miR-941 may serve as a promising oncogenic biomarker for diagnosing LSCC, and has the potential as a therapeutic target. +genetics_overexpression_promote 32742452 hsa-mir-370 Stomach Neoplasms UQCRC2 overexpression suppressed GC cell migration and invasion in vitro and in vivo, whereas up-regulating miR-370 reversed these effects. +other 32742441 hsa-mir-29a Stomach Neoplasms In summary, we uncovered the prognostic value of COL3A1/FBN1/COL5A2/SPARC-mir-29a-3p-H19 ceRNA network in gastric cancer. +genetics_knock down_promote 32742403 hsa-mir-1307 Colorectal Neoplasms Knockdown of miR +genetics_overexpression_promote 32742398 hsa-mir-4435-2 Osteoarthritis In addition, miR4435-2HG overexpression inhibited OA progression, suggesting that miR4435-2HG may be considered as a potential therapeutic target in OA. +target gene 32742380 hsa-mir-654 Ovarian Neoplasms MicroRNA-654-3p enhances cisplatin sensitivity by targeting QPRT and inhibiting the PI3K/AKT signaling pathway in ovarian cancer cells. +target gene 32742355 hsa-mir-425 Leukemia, Lymphocytic, Chronic, B-Cell MicroRNA-425 inhibits proliferation of chronic lymphocytic leukaemia cells through regulation of the Bruton's tyrosine kinase/phospholipase Cγ2 signalling pathway. +lncRNA target 32742352 hsa-mir-181 Norrie disease Overall, the results of the present study suggest that miR-181a-5p may have a crucial role in the occurrence and development of DN and may be a valuable diagnostic marker and therapeutic target for DN. +lncRNA target 32742352 hsa-mir-181a Norrie disease Overall, the results of the present study suggest that miR-181a-5p may have a crucial role in the occurrence and development of DN and may be a valuable diagnostic marker and therapeutic target for DN. +lncRNA target 32742346 hsa-mir-181a Cataract MIAT and CTGF were upregulated, while miR-181a was significantly downregulated in ARC tissues compared with normal tissues. The results suggested that MIAT may regulate the progression of ARC via the miR-181a/CTGF/ERK signaling pathway, which may serve as a novel therapeutic target for ARC. +lncRNA target 32742341 hsa-mir-363 Squamous Cell Carcinoma of Head and Neck OSCC cells of si-MCM3AP-AS1 inhibitor-NC group exhibited clearly lower relative proliferation, migration and invasion compared with cells of si-NC inhibitor-NC group and si-MCM3AP-AS1 miR +lncRNA target 32742334 hsa-mir-17 Iron Metabolism Disorders 3p inhibitor did not markedly affect the level of galectin-3, indicating that Dex alleviated the effects of I/R injury through other pathways. +lncRNA target 32742334 hsa-mir-17 Myocarditis Dexmedetomidine (Dex), an alpha(2)-adrenoceptor agonist, and the microRNA (miR)3p, have both been suggested to alleviate I/R injury and cardiac tissue inflammation. +lncRNA target 32742334 hsa-mir-17 Anodontia 3p inhibitor did not markedly affect the level of galectin-3, indicating that Dex alleviated the effects of I/R injury through other pathways. +lncRNA target 32742334 hsa-mir-17 Reperfusion Injury 3p inhibitor did not markedly affect the level of galectin-3, indicating that Dex alleviated the effects of I/R injury through other pathways. +target gene 32742198 hsa-mir-1252 Stomach Neoplasms Circ_0000190 suppresses gastric cancer progression potentially via inhibiting miR-1252/PAK3 pathway. +lncRNA target 32742197 hsa-mir-127 Carcinoma, Non-Small-Cell Lung CONCLUSION: In conclusion, our results suggest that LncRNA FOXD3-AS1 promotes chemo-resistance of NSCLC cells via directly acting on miR +lncRNA target 32742195 hsa-mir-149 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: Our study reveals that MIAT acts as an oncogene in NSCLC via a novel MIAT/miR-149/FOXM1 axis, thus providing potential biomarkers and therapeutic targets for the management of NSCLC. +circulation_biomarker_diagnosis_up 32742190 hsa-mir-3163 Uterine Cervical Neoplasms Cytoplasmic CTBP1-AS2 was found to be a miR-3163 sponge in CC cells. CONCLUSION: CTBP1-AS2 regulates CC progression via sponging miR-3163 to up-regulate ZNF217. +circulation_biomarker_diagnosis_ns 32741900 hsa-mir-206 Bone Diseases These findings demonstrate that serum miR-206 may serve as a highly specific biomarker for preclinical analysis of rats with drug-induced skeletal muscle injuries. +other 32741808 hsa-mir-361 Alzheimer Disease CONCLUSION: SNHG1 promoted cell injury by regulating the miR3p/ZNF217 axis, which might provide a theoretical basis for molecular therapy of AD. +other 32741804 hsa-mir-1 Adenocarcinoma of Lung And NAV2-AS2 - mir-31 - PRKCE and NAV2-SA2 - mir-31 - LATS2 were finally identified as ceRNA network involved in the progression of LUAD. +circRNA target 32741666 hsa-mir-190a Triple Negative Breast Neoplasms MATERIALS AND METHODS: The expression and correlation of circCDYL/miR-190a-3p/TP53INP1 axis in breast cancer tissues and cells were determined by quantitative polymerase chain reaction and Western blot. CONCLUSION: CircCDYL promotes apoptosis and inhibits proliferation of the malignant phenotype of breast cancer through regulating miR-190a-3p/TP53INP1 axis, which suggests that circCDYL is a potential therapeutic target for breast cancer. +circulation_biomarker_diagnosis_ns 32741216 hsa-mir-187 Carcinoma, Non-Small-Cell Lung Considering the number of specimens in this study, circulating serum exosomal miR-20b-5p and miR5p are putative NSCLC biomarkers, which need to be further investigated in a larger randomized controlled clinical trial. +lncRNA target 32740791 hsa-mir-503 Uterine Cervical Neoplasms 5p expression and inhibited its target gene expressions in CC cells. +other 32740774 hsa-mir-155 Breast Neoplasms A novel electrochemical nanobiosensor for the detection of miR-155 (as breast cancer biomarker) is introduced . +genetics_overexpression_promote 32740683 hsa-mir-197 Stomach Neoplasms Overexpression of miR-197 could markedly restrain hsa_circ_0001017-induced RHOB increasing and stifle inhibition of hsa_circ_0001017 to the malignant phenotype of GC cell lines. CONCLUSION: Our data demonstrated that upregulation of hsa_circ_0001017 could notably muffle the proliferation as well as the metastasis of GC cell lines and impede the formation of GC tumor via targeting to miR-197/RHOB signaling pathway. +circulation_biomarker_diagnosis_ns 32740403 hsa-mir-126 Hypertension CONCLUSION: Low serum levels of miR-126, miR-221, and miR-222 were associated with increased blood pressure and new-onset of hypertension. +circulation_biomarker_diagnosis_ns 32740403 hsa-mir-222 Hypertension CONCLUSION: Low serum levels of miR-126, miR-221, and miR-222 were associated with increased blood pressure and new-onset of hypertension. +circulation_biomarker_diagnosis_ns 32740403 hsa-mir-221 Hypertension CONCLUSION: Low serum levels of miR-126, miR-221, and miR-222 were associated with increased blood pressure and new-onset of hypertension. +lncRNA target 32740014 hsa-mir-760 Colorectal Neoplasms LINC00659/miR-760 axis might be an underlying target for CRC therapy. +circulation_biomarker_diagnosis_down 32739657 hsa-mir-140 Hip Dislocation, Congenital MiR-140 was downregulated in the serum of patients with DDH patients and in the hip joints of rats with DDH. +lncRNA target 32739469 hsa-mir-186 Esophageal Squamous Cell Carcinoma 5p /PARP9 axis in EC, which provided a might target for EC treatment. +circulation_biomarker_diagnosis_ns 32739158 hsa-mir-92a Amyotrophic Lateral Sclerosis 5p and serum HEL may be a useful biomarker for K-ALS in the Kii Peninsula. +circulation_biomarker_diagnosis_ns 32739158 hsa-mir-486 Amyotrophic Lateral Sclerosis 5p and serum HEL may be a useful biomarker for K-ALS in the Kii Peninsula. +genetics_overexpression_suppress 32738890 hsa-mir-34a Osteoarthritis Cell apoptosis analysis showed that overexpression of SNHG9 led to decreased apoptotic rate of chondrocytes from OA patients but not chondrocytes from the healthy controls through miR-34a. +lncRNA target 32738556 hsa-mir-27a Sepsis CONCLUSIONS: TUG1 could repress cell apoptosis, autophagy, and inflammatory response in LPS-treated HUVECs by sponging miR-27a-3p to target SLIT2, providing a potential target for the treatment of sepsis. +lncRNA target 32738449 hsa-mir-342 Carcinoma, Hepatocellular 3p, is a tumour suppressor in HCC. +genetics_overexpression_promote 32738347 hsa-mir-503 Colonic Neoplasms The promoting effects of MIR503HG silencing on colon cancer cells were eliminated by Par4 overexpression. +genetics_overexpression_promote 32738343 hsa-mir-375 Breast Neoplasms Here, we constructed breast cancer cells with miR-375 stable overexpression via lentivirus infection. +transcription factor target 32738187 hsa-mir-1224 Rectal Neoplasms 5p functioned as a tumor suppressor in RC, which achieved its function via targeting SLC29A3. +lncRNA target 32737775 hsa-mir-106a Squamous Cell Carcinoma of Head and Neck HK2 was a target of miR-106a-5p and miR-106a-5p played an anti-tumor role in OSCC by inhibiting HK2. +transcription factor target 32737769 hsa-mir-217 Pituitary Diseases Herein, we focused on the effect of hsa-miR5p (miR-217) on endothelial dysfunction induced by ox-LDL by targeting early growth response protein-1 (EGR1). +circulation_biomarker_diagnosis_ns 32737762 hsa-mir-567 Cognitive Dysfunction Hsa-mir-567 was found to be differentially expressed in cerebrospinal fluid samples, blood and serum from MCI-AD patients, showing the highest fold change and statistical significance. +circulation_biomarker_diagnosis_ns 32737762 hsa-mir-567 Alzheimer Disease Hsa-mir-567 was found to be differentially expressed in cerebrospinal fluid samples, blood and serum from MCI-AD patients, showing the highest fold change and statistical significance. +genetics_overexpression_promote 32737704 hsa-mir-135b Stomach Neoplasms EdU assays and cell migration assays respectively showed that miR-135b overexpression induced the growth and invasion of GC cells. +other 32737645 hsa-mir-26b Squamous Cell Carcinoma of Head and Neck CONCLUSION: Our results suggest that two miRNAs that modulate the glycolytic pathway, miR-26b and miR-155, are independently associated with the risk of recurrence in patients with HNSCC. +other 32737645 hsa-mir-155 Squamous Cell Carcinoma of Head and Neck CONCLUSION: Our results suggest that two miRNAs that modulate the glycolytic pathway, miR-26b and miR-155, are independently associated with the risk of recurrence in patients with HNSCC. +target gene 32737620 hsa-mir-143 Breast Neoplasms MicroRNA-143 targets MAPK3 to regulate the proliferation and bone metastasis of human breast cancer cells. +other 32737406 hsa-mir-378 Acquired Immunodeficiency Syndrome Moreover, the receiver operating characteristics (ROC) curve analyses of miR-630 and miR-378g yielded areas under the ROC curves of 0.82 (95% CI 0.67 to 0.82) and 0.83 (95% CI 0.67 to 0.83), respectively highlighting their potential to serve as biomarkers to identify HIV-1 infection in women. +other 32737406 hsa-mir-630 Acquired Immunodeficiency Syndrome Moreover, the receiver operating characteristics (ROC) curve analyses of miR-630 and miR-378g yielded areas under the ROC curves of 0.82 (95% CI 0.67 to 0.82) and 0.83 (95% CI 0.67 to 0.83), respectively highlighting their potential to serve as biomarkers to identify HIV-1 infection in women. +transcription factor target 32736708 hsa-mir-182 Uveitis 5p/TAF15 axis shows promise as a therapeutic target for uveitis. +lncRNA target 32736520 hsa-mir-138 Neuroblastoma CONCLUSIONS: MicroRNA-138 promotes cell apoptosis of SH-SY5Y by targeting DEK in SH-SY5Y AD cell model. +lncRNA target 32736520 hsa-mir-138 Alzheimer Disease CONCLUSIONS: MicroRNA-138 promotes cell apoptosis of SH-SY5Y by targeting DEK in SH-SY5Y AD cell model. +other 32736170 hsa-mir-199a Intervertebral Disc Degeneration Furthermore, injection of MSC/HP-anti-miR-199a/NS/NF-SMS can stay in place, produce functional extracellular matrix, maintain disc height and prevent intervertebral disc (IVD) calcification in a rabbit lumbar degeneration model. +other 32736170 hsa-mir-199 Intervertebral Disc Degeneration Furthermore, injection of MSC/HP-anti-miR-199a/NS/NF-SMS can stay in place, produce functional extracellular matrix, maintain disc height and prevent intervertebral disc (IVD) calcification in a rabbit lumbar degeneration model. +other 32736169 hsa-mir-148b Carcinoma, Squamous Cell, Epidermal Using this approach, we delivered exogenous miR-148b to induce apoptosis in Ras-expressing keratinocytes and murine squamous cell carcinoma cells while avoiding cytotoxicity in untransformed keratinocytes. +other 32736169 hsa-mir-148b Inflammation Using this approach, we delivered exogenous miR-148b to induce apoptosis in Ras-expressing keratinocytes and murine squamous cell carcinoma cells while avoiding cytotoxicity in untransformed keratinocytes. +epigenetics 32735911 hsa-mir-490 hereditary diffuse gastric cancer CHRM2, the host gene of miR490-3p, was hypermethylated and downregulated in neoplastic gastric tissues (P < 0.05). +lncRNA target 32735888 hsa-mir-524 Adenocarcinoma of Lung 3p to promote the proliferation, migration, and invasion of lung adenocarcinoma cells, suggesting that hsa_circ_0001588 may be an underlying therapeutic target for lung adenocarcinoma. +lncRNA target 32735880 hsa-mir-34a Breast Neoplasms Here, we proposed to achieve migration chain-treatment for metastatic tumors by introducing a cell adhesion molecules CD44 inhibitor (Star miR-34a) to deprive of cell migration capability on the basis of CXCR4 antagonism (cyclam monomer, CM). Moreover, DPC/miR-34a demonstrated a superior antitumor and anti-metastatic efficacy both in lung metastatic model and orthotopic MDA-MB-231 tumor models, thus providing an efficient approach for combating metastatic tumors. +other 32735806 hsa-mir-214 Hepatitis E In the current study, we have identified the functional importance of an interplay between hepatitis E virus (HEV) and miR-214. +lncRNA target 32735135 hsa-mir-186 Atherosclerosis 5p modulated AS cell proliferation and apoptosis via targeting WIPF2. +genetics_overexpression_suppress 32734729 hsa-mir-146b Hypoxia-Ischemia, Brain, Newborn Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to assess miR-146b-5p expression and inflammatory factors [interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha] in brain lesions and PC12 cells, while enzyme-linked immunosorbent assay was employed to detect the expression of oxidative stress factors (SOD and GSH-Px). Overexpression of miR-146b-5p greatly inhibited OGD-induced PC12 cell injury, inflammatory responses, and oxidative stress. +lncRNA target 32734584 hsa-mir-24-1 Hereditary pancreatitis Together, we show that maternal HP diminishes the bone mass of the offspring through miR +other 32734536 hsa-mir-615 Carcinoma, Non-Small-Cell Lung It is reported that LINC00324 promotes lung adenocarcinoma development by regulating miR5p/AKT1 axis. +lncRNA target 32734536 hsa-mir-139 Carcinoma, Non-Small-Cell Lung Highly expressed LINC00324 in NSCLC through sponged miR +other 32733962 hsa-mir-126 Mucocutaneous Lymph Node Syndrome Eight DE miRNAs were validated by real-time quantitative PCR (qRT-PCR) in complete or incomplete KD groups using a normalizer, miR3p, which was identified by geNorm and NormFinder tools. +epigenetics 32733958 hsa-mir-150 Squamous Cell Carcinoma of Head and Neck Our aim was to analyze the expression and diagnostic significance of NANOG in OSCC, and the possible mechanisms of its regulation, i.e., protein regulators on mRNA level (OCT4, SOX2, KLF4, AGR2, and NOTCH1), methylation status, copy number variation, and regulatory miRNAs, miR-145, miR-335, miR-150, miR-34a, miR-128, and miR-27a. There was also a correlation between T status of OSCC and the expression of miR-335 and miR-150 and a correlation of miR-150 with the N status of T2 OSCC. +epigenetics 32733958 hsa-mir-335 Squamous Cell Carcinoma of Head and Neck Our aim was to analyze the expression and diagnostic significance of NANOG in OSCC, and the possible mechanisms of its regulation, i.e., protein regulators on mRNA level (OCT4, SOX2, KLF4, AGR2, and NOTCH1), methylation status, copy number variation, and regulatory miRNAs, miR-145, miR-335, miR-150, miR-34a, miR-128, and miR-27a. There was also a correlation between T status of OSCC and the expression of miR-335 and miR-150 and a correlation of miR-150 with the N status of T2 OSCC. +circRNA target 32733938 hsa-mir-181b Osteosarcoma By releasing the inhibition of miR-181b on HK2 expression, leading to attenuated OS progression. On the whole, our study indicated that circFAT1(e2) exerted oncogenic roles in OS and suggested the circFAT1(e2)/miR-181b/HK2 axis might be a potential therapeutic target. +lncRNA target 32733928 hsa-mir-1258 Breast Neoplasms OBJECTIVE: This study is designed to clarify that miR-1258 targets E2F1 to regulate the proliferation and cell cycle of breast cancer (BC) cells and consequently suppress the progression of BC. +circulation_biomarker_diagnosis_ns 32733920 hsa-mir-133a Hypertension Conclusions: The findings suggest the significant role of decreased microRNA-133a levels in blood plasma of patients with AH in the pathogenesis and development of both HHD and LV DD. +circulation_biomarker_diagnosis_ns 32733920 hsa-mir-133a Ventricular Dysfunction, Left Conclusions: The findings suggest the significant role of decreased microRNA-133a levels in blood plasma of patients with AH in the pathogenesis and development of both HHD and LV DD. +target gene 32733789 hsa-mir-490 Breast Neoplasms Long Non-coding RNA RP11-480I12.5 Promotes the Proliferation, Migration, and Invasion of Breast Cancer Cells Through the miR-490-3p-AURKA-Wnt/β-Catenin Axis. +other 32733633 hsa-mir-22 Multiple Sclerosis RESULTS: The levels of VCAM-1, miRNA-22, and miRNA-29a expression were significantly elevated in the PD patients. +other 32733633 hsa-mir-22 Parkinson Disease RESULTS: The levels of VCAM-1, miRNA-22, and miRNA-29a expression were significantly elevated in the PD patients. +other 32733633 hsa-mir-29a Vasculitis RESULTS: The levels of VCAM-1, miRNA-22, and miRNA-29a expression were significantly elevated in the PD patients. +other 32733633 hsa-mir-22 Vasculitis RESULTS: The levels of VCAM-1, miRNA-22, and miRNA-29a expression were significantly elevated in the PD patients. +other 32733633 hsa-mir-29a Multiple Sclerosis RESULTS: The levels of VCAM-1, miRNA-22, and miRNA-29a expression were significantly elevated in the PD patients. +other 32733633 hsa-mir-29a Parkinson Disease RESULTS: The levels of VCAM-1, miRNA-22, and miRNA-29a expression were significantly elevated in the PD patients. +genetics_overexpression_promote 32733269 hsa-mir-223 Diabetes Mellitus Using human cell and platelet coculture, we demonstrate that diabetic platelet deficient of miR-223 fails to suppress VSMC proliferation, while overexpression of miR-223 in diabetic platelets suppressed the proliferation of VSMC to protect intimal hyperplasia. +lncRNA target 32733254 hsa-mir-183 Allergic Inflammation We present evidence that NF-kappaB-miR5p-BTG1 axis can serve as target for development of anti-allergy drug. +transcription factor target 32733234 hsa-mir-145 Parkinson Disease Through a case-control study, RT-qPCR technology was used to detect the expression of miR-874 and miR +transcription factor target 32733234 hsa-mir-874 Parkinson Disease Through a case-control study, RT-qPCR technology was used to detect the expression of miR-874 and miR +genetics_GWAS 32733112 hsa-mir-370 Depressive Disorder, Major Objective The objective of our study was to investigate the influence of 1846G>A polymorphism of the CYP2D6 gene on the concentration/dose indicator of mirtazapine, using findings on enzymatic activity of CYP2D6 (as evaluated by the 6M-THBC/pinoline ratio measurement) and on CYP2D6 expression level obtained by measuring the hsa-miR3p plasma levelsin patients suffering from recurrent depressive disorder. +exosome 32733020 hsa-mir-125a Colitis Moreover, combination of miR-125a and miR-125b agmior infusion also showed therapeutic effects for colitis, accompanied by decreased Th17 cell ratio. Collectively, this study demonstrates that IFN-gamma treatment promoted exosomes from MSCs to attenuate colitis through increasing the level of miR-125a and miR-125b, which binding on 3'-UTR of Stat3 to repress Th17 cell differentiation. +exosome 32733020 hsa-mir-125b Colitis Moreover, combination of miR-125a and miR-125b agmior infusion also showed therapeutic effects for colitis, accompanied by decreased Th17 cell ratio. Collectively, this study demonstrates that IFN-gamma treatment promoted exosomes from MSCs to attenuate colitis through increasing the level of miR-125a and miR-125b, which binding on 3'-UTR of Stat3 to repress Th17 cell differentiation. +lncRNA target 32732965 hsa-mir-1224 Squamous Cell Carcinoma of Head and Neck Experiments in vivo confirmed the suppressive effect of miR +lncRNA target 32732911 hsa-mir-1193 Glioblastoma By implementing a highly efficient high-throughput screening (HTS) platform using an in-house-constructed genome-wide human microRNA inhibitor library, we demonstrated that miR-1193 inhibition sensitized GBM tumor cells with DNA-PKcs deficiency. These data provide a preclinical theory for the application of miR-1193 inhibition as a potential synthetic lethal approach targeting GBM cancer cells with DNA-PKcs deficiency. +circRNA target 32732872 hsa-mir-26a Carcinoma, Hepatocellular Cancer cells isolated from HCC patients and HCC cell lines showed clearly upregulated expression of circ9119 and Janus kinase 1 (JAK1) with decreased levels of miR-26a compared to healthy controls and normal hepatic cells. These results showed that circ9119 could modulate apoptosis, and broadly, cell proliferation by competitively binding miR-26a, which targeted JAK1-STAT3, in HCC cell lines. +lncRNA target 32732173 hsa-mir-205 Pancreatic Carcinoma 5p/CDK6 axis, which may be a potential therapeutic target for PC. +other 32731869 hsa-mir-186 Brain Ischemia 5p serves as a potential diagnostic biomarker for patients with asymptomatic CAS, and predicts the occurrence of future CIEs. +other 32731869 hsa-mir-186 Carotid Stenosis 5p serves as a potential diagnostic biomarker for patients with asymptomatic CAS, and predicts the occurrence of future CIEs. +lncRNA target 32731816 hsa-mir-182 Ovarian Neoplasms Mechanistically, we showed that circMTO1 sponged miR5p to support KLF15 expression, eventually leading to inhibition of ovarian cancer progression. +genetics_overexpression_promote 32731550 hsa-mir-199b Colorectal Neoplasms Clinically, miR-199b downregulation was identified as the molecular mechanism responsible for SET overexpression in around half of metastatic CRC patients. +lncRNA target 32731058 hsa-mir-20a Adenocarcinoma of Lung In addition, we investigated the correlations between miR-320a expression and clinical characteristics through data collected from Gene Expression Omnibus (GEO) microarrays, and The Cancer Genome Atlas (TCGA) to determine the clinical role of miR-320a in lung adenocarcinoma. The lung adenocarcinoma groups had a significantly lower level of miR-320a expression than the control groups. +lncRNA target 32731058 hsa-mir-20a Carcinoma, Non-Small-Cell Lung In addition, we investigated the correlations between miR-320a expression and clinical characteristics through data collected from Gene Expression Omnibus (GEO) microarrays, and The Cancer Genome Atlas (TCGA) to determine the clinical role of miR-320a in lung adenocarcinoma. The lung adenocarcinoma groups had a significantly lower level of miR-320a expression than the control groups. +exosome 32730779 hsa-mir-17 Colorectal Neoplasms Taken together, these data provide a new understanding of the potential diagnostic value of exosomal miR +genetics_overexpression_promote 32730776 hsa-mir-23b Femur Head Necrosis Moreover, elevation of ZNF667 reversed the repression of SONFH induced by miR-23b-3p overexpression. +exosome 32730709 hsa-mir-23b Pulmonary Fibrosis 3p, which suppress SIRT3, resulting in the epithelial EV-induced phenotypic changes. +exosome 32730709 hsa-mir-494 Pulmonary Fibrosis 3p, which suppress SIRT3, resulting in the epithelial EV-induced phenotypic changes. +lncRNA target 32730696 hsa-mir-345 Depression 5p may be an effective target for TRD therapy. +genetics_overexpression_promote 32729957 hsa-mir-182 Breast Neoplasms After that, in order to evaluate the effects of circRNA_000554, miR-182, and ZFP36 on cellular process, we evaluated in vitro epithelial-mesenchymal transition (EMT) and in vivo tumor growth after delivering a series of overexpression plasmids, mimic, inhibitor, or shRNAs into BC cells. +circRNA target 32729955 hsa-mir-498 Liver Neoplasms miR-498 was a downstream target of circ_0000105, inhibiting liver cancer cell proliferation and promoting apoptosis. +lncRNA target 32729719 hsa-mir-138 Acute Lung Injury 5p could effectively increase the viability of damaged cells, promote cell proliferation, reduce apoptosis, inhibit the inflammatory response, reduce oxidative stress, and then relieve ALI symptoms. +circRNA target 32729669 hsa-mir-567 Carcinoma, Renal Cell Mechanistically, we revealed that silencing of circ NUP98 inhibited RCC progression by down-regulating of PRDX3 via up-regulation of miR-567. CircNUP98 acts as an oncogene by a novel STAT3/circ NUP98/miR-567/PRDX3 axis, which may provide a potential biomarker and therapeutic target for the treatment of RCC. +circRNA target 32729666 hsa-mir-502 Carcinoma, Renal Cell 5p-dependent SLC39A14 mechanism, suggesting circ_001842 is a potential target for RCC treatment. +circulation_biomarker_diagnosis_ns 32729534 hsa-mir-159c Breast Neoplasms The detection of miRNA159c in human serum provided a huge opportunity to explore the relationship between the abundance of this miRNA and the incidence of breast cancer (BC), and to further achieve effective detection of BC. +lncRNA target 32729521 hsa-mir-29a Alzheimer Disease Isothermal titration calorimetry measurements showed that the adsorption strength of FAM-DNA for CM-dex-WS(2) was one order of magnitude greater than its hybridization energy for a target microRNA (miR-29a) that is well-known as an Alzheimer's disease (AD) biomarker, leading to the unfavorable desorption of the DNA probe from the surface. +other 32729503 hsa-mir-492 Carcinoma, Pancreatic Ductal To address the lack of early diagnosis, we report a cost-effective paper-based biosensor for the detection of miRNA-492, which is recognised as a biomarker for pancreatic ductal adenocarcinoma. +other 32729466 hsa-mir-31 Parkinson Disease Recent researches indicated that hsa-microRNA 5010-3p (miR-5010) and hsa-microRNA 331-5p (miR-331) were significantly important for the detection of PD. For the high accuracy diagnosis of PD, the synchronous determination of miR-5010 and miR-331 was successfully realized on one rLFTS by labeling fluorescent molecules to different T-line. +other 32729466 hsa-mir-5010 Parkinson Disease Recent researches indicated that hsa-microRNA 5010-3p (miR-5010) and hsa-microRNA 331-5p (miR-331) were significantly important for the detection of PD. For the high accuracy diagnosis of PD, the synchronous determination of miR-5010 and miR-331 was successfully realized on one rLFTS by labeling fluorescent molecules to different T-line. +genetics_overexpression_promote 32729377 hsa-mir-182 Glioma 5p-induced proliferation, migration, and invasion of glioma cells could be abrogated by overexpressed circRNA Scm like with 4 Mbt domains 2. +lncRNA target 32729158 hsa-mir-363 Neurotoxicity Syndromes Significance of the study: The present study demonstrated that propofol induces oxidative stress and apoptosis via affecting miR +other 32729158 hsa-mir-363 Nervous System Diseases 3p was recognized to be participate in propofol-induced neurotoxicity. +genetics_knock down_promote 32728892 hsa-mir-24 Diabetes Mellitus, Type 1 3p/miR-27b-3p/OPG plasma signature that may be developed into a novel blood-based method to better stratify patients with type 1 diabetes and predict C-peptide loss. +genetics_knock down_promote 32728892 hsa-mir-23b Immune System Diseases 3p/miR-27b-3p/OPG plasma signature that may be developed into a novel blood-based method to better stratify patients with type 1 diabetes and predict C-peptide loss. +genetics_knock down_promote 32728892 hsa-mir-24 Immune System Diseases 3p/miR-27b-3p/OPG plasma signature that may be developed into a novel blood-based method to better stratify patients with type 1 diabetes and predict C-peptide loss. +genetics_knock down_promote 32728892 hsa-mir-23a Immune System Diseases 3p/miR-27b-3p/OPG plasma signature that may be developed into a novel blood-based method to better stratify patients with type 1 diabetes and predict C-peptide loss. +genetics_knock down_promote 32728892 hsa-mir-27b Immune System Diseases 3p/miR-27b-3p/OPG plasma signature that may be developed into a novel blood-based method to better stratify patients with type 1 diabetes and predict C-peptide loss. +genetics_knock down_promote 32728892 hsa-mir-23b Diabetes Mellitus, Type 1 3p/miR-27b-3p/OPG plasma signature that may be developed into a novel blood-based method to better stratify patients with type 1 diabetes and predict C-peptide loss. +genetics_knock down_promote 32728892 hsa-mir-23a Diabetes Mellitus, Type 1 3p/miR-27b-3p/OPG plasma signature that may be developed into a novel blood-based method to better stratify patients with type 1 diabetes and predict C-peptide loss. +genetics_knock down_promote 32728892 hsa-mir-27b Diabetes Mellitus, Type 1 3p/miR-27b-3p/OPG plasma signature that may be developed into a novel blood-based method to better stratify patients with type 1 diabetes and predict C-peptide loss. +lncRNA target 32728178 hsa-mir-202 Osteosarcoma MALAT1 was also high in osteosarcoma cells KRIB and MALAT1's targeted downregulation in these cells led to decreased invasive potential and identification of miR-202 as the miRNA that is sponged by MALAT1. In conclusion, MALAT1-miR-202 represents a potential lncRNA-miRNA signature that affects lung metastasis of osteosarcomas and could potentially be targeted for therapy. +other 32728112 hsa-mir-6718 Leukemia, Myeloid, Acute We identified that the majority of measured miRNAs was downregulated in the short-lived group and we found differentially expressed microRNAs between both subgroups that have not been reported for AML so far (miR2, miR-3065, miR-95, miR-6718) suggesting that miRNAs could be important for prognosis. +other 32728112 hsa-mir-153-2 Leukemia, Myeloid, Acute We identified that the majority of measured miRNAs was downregulated in the short-lived group and we found differentially expressed microRNAs between both subgroups that have not been reported for AML so far (miR2, miR-3065, miR-95, miR-6718) suggesting that miRNAs could be important for prognosis. +other 32728112 hsa-mir-3065 Leukemia, Myeloid, Acute We identified that the majority of measured miRNAs was downregulated in the short-lived group and we found differentially expressed microRNAs between both subgroups that have not been reported for AML so far (miR2, miR-3065, miR-95, miR-6718) suggesting that miRNAs could be important for prognosis. +other 32728112 hsa-mir-95 Leukemia, Myeloid, Acute We identified that the majority of measured miRNAs was downregulated in the short-lived group and we found differentially expressed microRNAs between both subgroups that have not been reported for AML so far (miR2, miR-3065, miR-95, miR-6718) suggesting that miRNAs could be important for prognosis. +circulation_biomarker_prognosis_ns 32728103 hsa-mir-375 Small Cell Lung Carcinoma Furthermore, Kaplan-Meier survival analysis confirmed that high expression of miR-92b and miR-375 was closely related to shorter progression-free survival (PFS) in SCLC patients. In conclusion, these findings indicate that circulating miR-92b and miR-375 might be ideal noninvasive biomarkers for monitoring drug resistance during chemotherapy and evaluating the prognosis of patients with SCLC. +circulation_biomarker_prognosis_ns 32728103 hsa-mir-92b Small Cell Lung Carcinoma Furthermore, Kaplan-Meier survival analysis confirmed that high expression of miR-92b and miR-375 was closely related to shorter progression-free survival (PFS) in SCLC patients. In conclusion, these findings indicate that circulating miR-92b and miR-375 might be ideal noninvasive biomarkers for monitoring drug resistance during chemotherapy and evaluating the prognosis of patients with SCLC. +lncRNA target 32728069 hsa-mir-200a Endometriosis Our findings demonstrate that abnormal upregulation of circATRNL1 regulates cell proliferation and motility and promotes EMT process via the miR +lncRNA target 32728069 hsa-mir-141 Endometriosis Our findings demonstrate that abnormal upregulation of circATRNL1 regulates cell proliferation and motility and promotes EMT process via the miR +genetics_knock down_promote 32728015 hsa-mir-767 Stomach Neoplasms Moreover, overexpression of miR +lncRNA target 32727972 hsa-let-7a Carcinoma, Ovarian Epithelial It is known that let-7a microRNA, a member of the let-7 family, inhibits growth of endometrial carcinoma cells targeting Aurora-B that controls progression through each phase of mitosis. +lncRNA target 32727972 hsa-let-7c Carcinoma, Ovarian Epithelial We thus studied whether let-7c mediates Aurora-B expression in ESC cells. These results indicate that let-7c mediates paclitaxel resistance via inhibition of Aurora-B expression in ESC cells. +other 32727776 hsa-mir-19a-2 Precursor Cell Lymphoblastic Leukemia-Lymphoma CONCLUSION: The miR-19a-2 genotypes are not associated with susceptibility to childhood ALL in Taiwan. +other 32727744 hsa-mir-196b Fibrosis, Renal CONCLUSION: This study demonstrates the involvement of miR-196b-5p-EVs pathway as a novel mechanism in aldosterone-induced renal fibrosis in diabetes. EVs rich in miR-196b-5p mediate the crosstalk between PTECs and fibroblast during the development of renal fibrosis, which might be associated with STAT3/SOCO2 signaling pathway. +other 32727744 hsa-mir-196b Diabetes Mellitus CONCLUSION: This study demonstrates the involvement of miR-196b-5p-EVs pathway as a novel mechanism in aldosterone-induced renal fibrosis in diabetes. EVs rich in miR-196b-5p mediate the crosstalk between PTECs and fibroblast during the development of renal fibrosis, which might be associated with STAT3/SOCO2 signaling pathway. +lncRNA target 32727645 hsa-mir-124 Glioma Objective To investigate the effect of circular RNA homeodomain-interacting protein kinase 3 (circHIPK3) on the proliferation and metastasis of glioma cells via sponging miR +other 32727450 hsa-mir-17 Colonic Neoplasms Also, the ceRNA network data demonstrated that three lncRNAs including MIR17HG, H19, SNHG1, KCNQ1OT1, MALAT1, GAS5, SNHG20, OR2A1-AS1, and MAGI2-AS3 genes were involved in the development of COAD. +other 32727232 hsa-mir-124 Cognition Disorders CONCLUSIONS: LncRNA-MYL2-2 and miRNA3p may jointly participate in the occurrence and development of PND after cardiac surgery. +lncRNA target 32727098 hsa-mir-4516 Renal Insufficiency, Chronic Melatonin treatment suppressed fibrosis by inhibiting cytoskeleton reorganization and restoring mitochondrial function via increased miR-4516 expression. +transcription factor target 32727087 hsa-mir-762 Acute Kidney Injury (4) Conclusion: Besides already known miRNAs, septic AKI upregulated miR-762, which may regulate GTP signaling, and miR3p and downregulated its target, aquaporin-1. +transcription factor target 32727087 hsa-mir-144 Acute Kidney Injury (4) Conclusion: Besides already known miRNAs, septic AKI upregulated miR-762, which may regulate GTP signaling, and miR3p and downregulated its target, aquaporin-1. +exosome 32727045 hsa-mir-365a Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: These results confirm that miR-365 is not only expressed in oral cancer cell lines, but also is subsequently exported into exosomes and extracellular vesicles derived from these cultures. +exosome 32727045 hsa-mir-365 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: These results confirm that miR-365 is not only expressed in oral cancer cell lines, but also is subsequently exported into exosomes and extracellular vesicles derived from these cultures. +other 32726984 hsa-mir-451a Lung Neoplasms CONCLUSIONS: The 3-miRNA signature (miR5p, miR-92a-3p, miR-451a) had high specificity (100%) and sensitivity (84%) to predict cancer (LUAD and LUSC). +other 32726984 hsa-mir-16 Lung Neoplasms CONCLUSIONS: The 3-miRNA signature (miR5p, miR-92a-3p, miR-451a) had high specificity (100%) and sensitivity (84%) to predict cancer (LUAD and LUSC). +other 32726984 hsa-mir-92a Lung Neoplasms CONCLUSIONS: The 3-miRNA signature (miR5p, miR-92a-3p, miR-451a) had high specificity (100%) and sensitivity (84%) to predict cancer (LUAD and LUSC). +circulation_biomarker_diagnosis_ns 32726711 hsa-mir-125b Pre-Eclampsia We also found that Trop-2 is a target of miR-125b in placental cells; its localization in the basal part of the syncytiotrophoblast plasma membrane suggests a role for it in the early onset of PE. +other 32726517 hsa-mir-1972 Prostatic Neoplasms Thus, we explored the role of LINC01207 and miR-1972 in the growth and progression of prostate cancer. Quantitative real-time polymerase chain reaction revealed that LINC01207 and LASP1 were highly expressed in prostate cancer, while miR-1972 expression was lower. +genetics_overexpression_suppress 32726486 hsa-mir-338 Breast Neoplasms 3p overexpression inhibited BC cell proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) process, whereas miR +genetics_knock down_promote 32726127 hsa-mir-662 Carcinoma, Hepatocellular Overexpression of miR-3662 or knockdown of HK2 inhibited cell proliferation, invasion, and glucose metabolism in HCC cells, which could be reversed by upregulating HK2. +lncRNA target 32726126 hsa-mir-613 Glioma Low-expression of LINC00152 modified cell proliferation, apoptosis migration and invasion through LINC00152/miR-613/CD164 axis via PI3K/AKT signaling pathway in glioma, thus providing new therapeutic target in the clinical treatment of glioma. +lncRNA target 32726125 hsa-mir-375 Osteosarcoma In conclusion, miR-375 suppressed cells autophagy and tumor growth in DDP-resistant U2OS/DDP and MG63/DDP cells by targeting ATG2B, providing a potential target for the treatment of DDP-resistant OS. +other 32726117 hsa-mir-217 Colorectal Neoplasms RESULTS: Expression levels of miR-217, mR-181d, miR-663, miR-27 and K-ras were found to be higher in CRC tissues than in adjacent tumor-free tissues of the patients. CONCLUSIONS: Increased miR-181d and miR-217 expression levels are associated with increased K-ras expression in the tumor tissues, and the expression of K-ras, which takes part as an oncogene in the CRC development, might be regulated by these miRNAs (Tab. +lncRNA target 32725768 hsa-mir-141 Stomach Neoplasms Down-regulation of HCG18 inhibited viability, migration, and invasion of GC cells, while miR +circulation_biomarker_diagnosis_ns 32725652 hsa-mir-155 Ischemic Stroke Our study suggests that plasma EMVs and EMVs-miR-155 are promising biomarkers for IS. +genetics_GWAS 32725161 hsa-mir-1246 Breast Neoplasms However, the roles of miRNAs in diseases are prominently diverged, for instance, Genetic variants of miRNA (mir-15) may affect the expression level of miRNAs leading to B cell chronic lymphocytic leukemia, while circulating miRNAs (including mir-1246, mir3p, etc.) have potentials to detecting breast cancer in the early stage. +genetics_GWAS 32725161 hsa-mir-1246 Leukemia, Lymphocytic, Chronic, B-Cell However, the roles of miRNAs in diseases are prominently diverged, for instance, Genetic variants of miRNA (mir-15) may affect the expression level of miRNAs leading to B cell chronic lymphocytic leukemia, while circulating miRNAs (including mir-1246, mir3p, etc.) have potentials to detecting breast cancer in the early stage. +genetics_GWAS 32725161 hsa-mir-1246 Genetic Diseases, Inborn However, the roles of miRNAs in diseases are prominently diverged, for instance, Genetic variants of miRNA (mir-15) may affect the expression level of miRNAs leading to B cell chronic lymphocytic leukemia, while circulating miRNAs (including mir-1246, mir3p, etc.) have potentials to detecting breast cancer in the early stage. +genetics_GWAS 32725161 hsa-mir-15 Leukemia, Lymphocytic, Chronic, B-Cell However, the roles of miRNAs in diseases are prominently diverged, for instance, Genetic variants of miRNA (mir-15) may affect the expression level of miRNAs leading to B cell chronic lymphocytic leukemia, while circulating miRNAs (including mir-1246, mir3p, etc.) have potentials to detecting breast cancer in the early stage. +genetics_GWAS 32725161 hsa-mir-1307 Leukemia, Lymphocytic, Chronic, B-Cell However, the roles of miRNAs in diseases are prominently diverged, for instance, Genetic variants of miRNA (mir-15) may affect the expression level of miRNAs leading to B cell chronic lymphocytic leukemia, while circulating miRNAs (including mir-1246, mir3p, etc.) have potentials to detecting breast cancer in the early stage. +genetics_GWAS 32725161 hsa-mir-15 Breast Neoplasms However, the roles of miRNAs in diseases are prominently diverged, for instance, Genetic variants of miRNA (mir-15) may affect the expression level of miRNAs leading to B cell chronic lymphocytic leukemia, while circulating miRNAs (including mir-1246, mir3p, etc.) have potentials to detecting breast cancer in the early stage. +genetics_GWAS 32725161 hsa-mir-1307 Genetic Diseases, Inborn However, the roles of miRNAs in diseases are prominently diverged, for instance, Genetic variants of miRNA (mir-15) may affect the expression level of miRNAs leading to B cell chronic lymphocytic leukemia, while circulating miRNAs (including mir-1246, mir3p, etc.) have potentials to detecting breast cancer in the early stage. +genetics_GWAS 32725161 hsa-mir-1307 Breast Neoplasms However, the roles of miRNAs in diseases are prominently diverged, for instance, Genetic variants of miRNA (mir-15) may affect the expression level of miRNAs leading to B cell chronic lymphocytic leukemia, while circulating miRNAs (including mir-1246, mir3p, etc.) have potentials to detecting breast cancer in the early stage. +genetics_GWAS 32725161 hsa-mir-15 Genetic Diseases, Inborn However, the roles of miRNAs in diseases are prominently diverged, for instance, Genetic variants of miRNA (mir-15) may affect the expression level of miRNAs leading to B cell chronic lymphocytic leukemia, while circulating miRNAs (including mir-1246, mir3p, etc.) have potentials to detecting breast cancer in the early stage. +circulation_biomarker_prognosis_up 32724822 hsa-mir-181a Carcinoma, Non-Small-Cell Lung Conclusions Serum miR +circulation_biomarker_diagnosis_ns 32724801 hsa-mir-552 Ischemic Stroke CONCLUSION: Our findings reveal that circulating miR-3552 shows promise as a potential biomarker for ischemic stroke in rats. +genetics_GWAS 32724662 hsa-mir-129-2 Leukemia, Lymphocytic, Chronic, B-Cell 2 gene in the CLL group compared to the control group, as well as its significant association with organomegaly, suggests the importance of this epigenetic biomarker in the pathogenesis and prognosis of CLL disease. +lncRNA target 32724496 hsa-mir-873 Parkinson Disease The results suggest that the inhibition of miR-873 may play a dual protective role by improving intracellular cholesterol homeostasis and neuroinflammation in PD. +lncRNA target 32724447 hsa-mir-9 Glioma 3p may serve as a diagnostic target and novel prognostic marker in patients with glioma. +genetics_overexpression_promote 32724440 hsa-mir-494 Retinoblastoma Functional assays showed that RB cell proliferation, invasion and migration can be promoted by miR-494 overexpression. +circulation_biomarker_prognosis_ns 32724438 hsa-mir-372 Leukemia, Myeloid, Acute The expression levels of miR-372 and miR-495 in the peripheral blood of the subjects were detected by reverse transcriptase quantitative PCR, and their diagnostic and prognostic values in AML were analyzed. +circulation_biomarker_prognosis_ns 32724438 hsa-mir-495 Leukemia, Myeloid, Acute The expression levels of miR-372 and miR-495 in the peripheral blood of the subjects were detected by reverse transcriptase quantitative PCR, and their diagnostic and prognostic values in AML were analyzed. +genetics_overexpression_promote 32724437 hsa-mir-147 Carcinoma, Non-Small-Cell Lung Furthermore, overexpression of miR-147 inhibited the viability and metastasis of NSCLC cells. +circulation_biomarker_diagnosis_ns 32724436 hsa-mir-195 Prostatic Neoplasms 5p in patient serum. +circulation_biomarker_diagnosis_ns 32724436 hsa-mir-493 Prostatic Neoplasms 5p in patient serum. +lncRNA target 32724428 hsa-mir-152 Glioma 3p, and rescue experiments confirmed that EWSAT1 participated in glioma development by suppressing miR +other 32724426 hsa-mir-500a Leukemia, Myeloid, Acute 5p, LINC00987, LACAT143, THCAT393, THCAT531 and KHCAT230 expression levels had a shorter survival time compared with those without these factors. +other 32724426 hsa-mir-500b Leukemia, Myeloid, Acute 5p, LINC00987, LACAT143, THCAT393, THCAT531 and KHCAT230 expression levels had a shorter survival time compared with those without these factors. +other 32724426 hsa-let-7a-2 Leukemia, Myeloid, Acute 5p, LINC00987, LACAT143, THCAT393, THCAT531 and KHCAT230 expression levels had a shorter survival time compared with those without these factors. +other 32724426 hsa-mir-362 Leukemia, Myeloid, Acute 5p, LINC00987, LACAT143, THCAT393, THCAT531 and KHCAT230 expression levels had a shorter survival time compared with those without these factors. +transcription factor target 32724414 hsa-mir-98 Diabetes Mellitus miR-98 inhibits proliferation and invasion of diabetic colon cancer by targeting IGF1R. +transcription factor target 32724414 hsa-mir-98 Colonic Neoplasms miR-98 inhibits proliferation and invasion of diabetic colon cancer by targeting IGF1R. +genetics_overexpression_promote 32724408 hsa-mir-505 Glioma Moreover, overexpression of miR +circulation_biomarker_diagnosis_ns 32724386 hsa-mir-21 Pancreatic Carcinoma The present study identified that serum ex-miRNAs, miRNA-21 and miRNA-210 may be of value as potential biomarkers and therapeutic targets for the diagnosis and treatment of PC. +circulation_biomarker_diagnosis_ns 32724386 hsa-mir-210 Pancreatic Carcinoma The present study identified that serum ex-miRNAs, miRNA-21 and miRNA-210 may be of value as potential biomarkers and therapeutic targets for the diagnosis and treatment of PC. +lncRNA target 32724385 hsa-mir-191 Carcinoma, Hepatocellular Collectively, these preclinical findings suggest that IGF2BP3 increases HCC cell invasiveness by promoting the miR191-5p-induced suppression of ZO-1 signaling. +lncRNA target 32724375 hsa-mir-126 Ovarian Neoplasms The above findings suggested that miR-126 served as a cancer suppressor in OC, suggesting a promising application of miR-126 in the clinical diagnosis and therapeutics of OC. +genetics_knock down_promote 32724369 hsa-mir-876 Stomach Neoplasms 5p knockdown promoted GC cell proliferation and decreased cisplatin sensitivity of GC cells. +genetics_overexpression_promote 32724366 hsa-mir-200a Carcinoma, Non-Small-Cell Lung Overexpression of miR-200a inhibited NSCLC cell proliferation and promoted apoptosis. The current study proposes that miR-200a exhibits a tumor suppressive role in NSCLC and suggests that miR-200a could target RHPN2. +genetics_knock down_promote 32724361 hsa-mir-518b Carcinoma, Non-Small-Cell Lung Furthermore, the cell experiments indicated that NSCLC cell proliferation, migration and invasion were enhanced following overexpression of miR-518b; however, these effects were reversed following miR-518b knockdown. +circulation_biomarker_diagnosis_up 32724351 hsa-mir-592 Colorectal Neoplasms Taken together, the results of the present study suggest that serum miR-592 may be implicated as a potential biomarker for the early diagnosis of CRC. +transcription factor target 32724322 hsa-mir-21 Carcinoma, Hepatocellular Interestingly, the effect of miR-21 inhibition on cell proliferation, apoptosis, and TGF-beta1/smad3 signaling pathway in HepG2 and HCCLM3 cells exposed to curcumin was attenuated by TIMP3 silencing. +lncRNA target 32724027 hsa-let-7b Sepsis CONCLUSIONS Our data show that the lower expression of NEAT1 impeded sepsis development and LPS-induced injury inflammation by targeting let-7b-5p/TRAF6 axis, and NEAT1 may be a target for treatment of sepsis patients. +lncRNA target 32724027 hsa-let-7b Inflammation CONCLUSIONS Our data show that the lower expression of NEAT1 impeded sepsis development and LPS-induced injury inflammation by targeting let-7b-5p/TRAF6 axis, and NEAT1 may be a target for treatment of sepsis patients. +circulation_biomarker_diagnosis_ns 32723508 hsa-mir-126 Diabetes Mellitus, Type 2 3p and miR-126 and high plasma levels of miR-150 at baseline showed a higher risk of developing T2DM after consumption of the Med diet. +circulation_biomarker_diagnosis_ns 32723508 hsa-mir-29a Diabetes Mellitus, Type 2 3p and miR-126 and high plasma levels of miR-150 at baseline showed a higher risk of developing T2DM after consumption of the Med diet. +lncRNA target 32723328 hsa-mir-183 Neuralgia Mechanistically, NF-kappaB p65 downregulated the miR-183 expression via the upregulation of HDAC2 and further induced inflammatory response by activating the TXNIP-NLRP3 inflammasome axis, thus aggravating the neuropathic pain in CCI rats and microglial cells. CONCLUSION: These results revealed a novel transcriptional mechanism of interplay between NF-kappaB and HDAC2 focusing on neuropathic pain via the miR-183/TXNIP/NLRP3 axis. +circulation_biomarker_diagnosis_ns 32723190 hsa-mir-122 Coronary Stenosis 5p might be useful as a diagnostic biomarker for AMI and UA, and increased serum exosomal miR +circulation_biomarker_diagnosis_ns 32723190 hsa-mir-122 Acute Coronary Syndrome 5p might be useful as a diagnostic biomarker for AMI and UA, and increased serum exosomal miR +exosome 32722884 hsa-mir-342 Carcinoma, Hepatocellular CONCLUSIONS: Exosomal ASMTL-AS1 aggravates the malignancy in residual HCC after insufficient RFA via miR +lncRNA target 32722658 hsa-mir-452 Stomach Neoplasms Reversion assays indicated that circKIAA0907 served as a tumor inhibitor by inhibiting miR +genetics_overexpression_suppress 32721950 hsa-mir-34c Diabetic Nephropathies Either miR-34c inhibition or NLRP3 overexpression could reverse the accentuation of pyroptosis and inflammation by sh-NEAT1 transfection in the in vitro model of DN. +other 32721879 hsa-mir-144 Cholangiocarcinoma The genes involved in RNA splicing and protein degradation processes and miR3p may play fundamental roles in the pathogenesis of CHOL. +lncRNA target 32721878 hsa-mir-558 Stomach Neoplasms In conclusion, circREPS2 suppresses the progression of GC via miR-558/RUNX3/beta-catenin signaling and is a novel promising biomarker and target for GC treatment. +epigenetics 32721616 hsa-let-7a Pre-Eclampsia The results revealed let-7a was highly expressed in early-onset severe PE and let-7a-3 presented a low methylation level. +other 32721573 hsa-mir-92b Hepatitis C We developed a cell sensor that detects the liver cancer-specific microRNA MIR92b-3p, involved in hepatocellular carcinoma development and hepatitis C virus infection. +other 32721573 hsa-mir-92b Carcinoma, Hepatocellular We developed a cell sensor that detects the liver cancer-specific microRNA MIR92b-3p, involved in hepatocellular carcinoma development and hepatitis C virus infection. +other 32721573 hsa-mir-92b Liver Neoplasms We developed a cell sensor that detects the liver cancer-specific microRNA MIR92b-3p, involved in hepatocellular carcinoma development and hepatitis C virus infection. +lncRNA target 32721464 hsa-mir-708 Inflammation Sum up, these results indicated that miR-708 might inhibit the liver inflammation and lipid accumulation by targeting ZEB1 via regulating AKT/mTOR signaling pathway. +lncRNA target 32721464 hsa-mir-708 Fatty Liver Sum up, these results indicated that miR-708 might inhibit the liver inflammation and lipid accumulation by targeting ZEB1 via regulating AKT/mTOR signaling pathway. +exosome 32721218 hsa-mir-519a Glioblastoma Conclusions: Exosomal lncRNA HOTAIR mediated TMZ resistance through miR-519a-3p/RRM1 axis in GB. +transcription factor target 32721050 hsa-mir-503 Obesity Thus, our results showed that IRS-1 regulated brown preadipocyte differentiation and induced browning in sWAT through the miRBMPR1a pathway, which played important roles in high-fat diet-induced obesity. +lncRNA target 32720795 hsa-mir-21 Spinal Cord Injuries Moreover, the effects of agomir-21 and antagomir-21 on SCI-induced expressions of inflammatory factors interleukin-8 (IL-8), IL-1beta, IL-6 and tumor necrosis factor-alpha (TNF-alpha) in spinal cord tissues were detected through qRT-PCR. +lncRNA target 32720740 hsa-mir-5688 Carcinoma, Non-Small-Cell Lung Recombinant human IL-11 counteracted the effects of miR-495 and miR-5688 on NSCLC cells, suggesting that miR-495 and miR-5688 executed their tumor suppressive role by repressing IL-11 expression. +lncRNA target 32720740 hsa-mir-495 Carcinoma, Non-Small-Cell Lung Recombinant human IL-11 counteracted the effects of miR-495 and miR-5688 on NSCLC cells, suggesting that miR-495 and miR-5688 executed their tumor suppressive role by repressing IL-11 expression. +transcription factor target 32720739 hsa-mir-145 Meningioma And miR-145 was found to target COL5A1, the interaction between which was shown to be involved in the pathogenesis of invasive meningioma. +genetics_overexpression_suppress 32720731 hsa-mir-1225 Carcinoma, Hepatocellular RESULTS: Overexpression of p65 protein counteracted the repressive impact of miR-1225 on invasion, migration, and proliferation of HCC cells. +lncRNA target 32720699 hsa-mir-1228 Fibrosis 3p markedly inhibited the progression of renal fibrosis in vitro, indicating that miRNA +transcription factor target 32720595 hsa-mir-211 Fractures, Bone CONCLUSION: Our data indicate that miRNA-211 functions via the TGF-beta/PI3K/Akt signaling pathway in patients with fractures. +genetics_knock down_suppress 32720593 hsa-mir-449b Glioblastoma Reduction of miR-449b-5p reversed the repressive effects of small nucleolar RNA host gene 7 knockdown on cellular behaviors in glioblastoma. +circulation_biomarker_diagnosis_ns 32720541 hsa-mir-155 Acute Lung Injury CONCLUSION miR-155 is highly expressed in plasma of patients with septic ALI/ARDS; it is positively correlated with lung function and can be used for early diagnosis. +circulation_biomarker_diagnosis_ns 32720541 hsa-mir-155 Respiratory Distress Syndrome CONCLUSION miR-155 is highly expressed in plasma of patients with septic ALI/ARDS; it is positively correlated with lung function and can be used for early diagnosis. +circulation_biomarker_diagnosis_ns 32720541 hsa-mir-155 Sepsis CONCLUSION miR-155 is highly expressed in plasma of patients with septic ALI/ARDS; it is positively correlated with lung function and can be used for early diagnosis. +lncRNA target 32720371 hsa-mir-485 Esophageal Squamous Cell Carcinoma CONCLUSION: We proved that LINC00467 acted as an oncogene in ESCC by accelerating cell proliferation and preventing cell apoptosis via miR +other 32720075 hsa-mir-374a Sleep Apnea, Obstructive 3p. +other 32720075 hsa-mir-26a Sleep Apnea, Obstructive 3p. +other 32720075 hsa-mir-26a Alzheimer Disease 3p. +other 32720075 hsa-mir-374a Alzheimer Disease 3p. +other 32720074 hsa-mir-181b Hypoxia-Ischemia, Brain Changes in miR-374a, miR-181b and miR-181a appeared specific to moderate-severe HI. +other 32720074 hsa-mir-181a Hypoxia-Ischemia, Brain Changes in miR-374a, miR-181b and miR-181a appeared specific to moderate-severe HI. +other 32720074 hsa-mir-374a Hypoxia-Ischemia, Brain Changes in miR-374a, miR-181b and miR-181a appeared specific to moderate-severe HI. +transcription factor target 32719988 hsa-mir-485 Hypoxia 5p protects primary cortical neurons against hypoxia injury through downregulating SOX6 and inhibiting MAPK pathway. +genetics_knock down_promote 32719443 hsa-mir-338 Carcinoma, Renal Cell Ectopic expression and knockdown of SBF2-AS1 and miR +genetics_knock down_promote 32719439 hsa-mir-93 Carcinoma, Hepatocellular 5p significantly retarded tumor growth, while overexpression of miR +lncRNA target 32719361 hsa-mir-3622a Colorectal Neoplasms The CRC organoid model was constructed with fresh CRC tissues and the growth of organoids was suppressed by miR-3622a-3p. +lncRNA target 32718270 hsa-mir-210 Pancreatic Carcinoma 5p, then inhibiting anaerobic glycolytic flux and inducing energy stress via repressing the expression of p-PFKFB2 and activity of LDH. +lncRNA target 32718197 hsa-mir-143 Inflammation Therefore, we aimed to investigate the effect of targeting microRNA-143 and inflammatory pathway by Fucoidan on experimentally induced hepatocellular carcinoma (HCC) in rats. +lncRNA target 32718197 hsa-mir-143 Carcinoma, Hepatocellular Therefore, we aimed to investigate the effect of targeting microRNA-143 and inflammatory pathway by Fucoidan on experimentally induced hepatocellular carcinoma (HCC) in rats. +lncRNA target 32718090 hsa-mir-711 Nerve Degeneration Significantly, we showed that brain irradiation in vivo persistently elevated miR-711, downregulated its targets, including pro-survival and DNA-repair molecules, and is associated with markers of neurodegeneration, not only across the cortex and hippocampus but also specifically in neurons isolated from the irradiated brain. +other 32718068 hsa-mir-221 Ovarian Neoplasms Bioinformatics analysis showed potential roles for LOC642852 as part of the TLE3/miR3p ceRNA network and in relation to the FGFR3 protein. +circRNA target 32717724 hsa-mir-152 Osteoporosis CONCLUSIONS: In conclusion, our study revealed that hsa_circ_0076690 may act as a potential diagnostic biomarker for osteoporosis patients and hsa_circ_0076690 could regulate osteogenic differentiation of hBMSCs via sponging miR-152. +circulation_biomarker_diagnosis_up 32717421 hsa-mir-21 Diabetic Cardiomyopathies The circulating miR-21 levels were significantly decreased in the DCM group compared to the non-DCM group (P < 0.001). CONCLUSIONS: Our findings identify circulating miR-21 as a novel biomarker in the diagnosis of DCM and provide an underlying mechanism for miRNA-based therapy for the treatment of DCM. +lncRNA target 32717360 hsa-mir-34 Chondrosarcoma MATERIAL AND METHODS: Chondrosarcoma cells (CH-2879) were exposed to carbon-ion irradiation, combined with miR-34 mimic and/or rapamycin administration. RESULTS: We show that high-grade chondrosarcoma cells contain a population of radioresistant cancer stem cells that can be targeted by a combination of carbon-ion therapy, miR-34 mimic administration and/or rapamycin treatment that triggers FOXO3 and miR-34 over-expression. +other 32717030 hsa-mir-17 Lymphoma Both invoked BIM-dependent apoptosis and in vivo therapy, associated with miR-17 approximately 92 repression, in murine Emicro-myc lymphomas, with PLX2853 exhibiting enhanced potency. +genetics_overexpression_promote 32716585 hsa-mir-375 Urinary Bladder Neoplasms 3p overexpression inhibited proliferation and migration and promoted apoptosis in BC cells. +genetics_overexpression_promote 32716350 hsa-mir-629 Carcinoma, Non-Small-Cell Lung More importantly, overexpression of FOXO1 weakened the carcinogenesis of miR-629 in NSCLC. +circRNA target 32716343 hsa-mir-384 Carcinoma, Non-Small-Cell Lung In this study, we focus on the effect of circ_0000376 targeting miR-384 on malignant phenotypes of NSCLC cells. METHODS: Circ_0000376 and miR-384 expression in NSCLC tissue samples were measured using qRT-PCR. +circulation_biomarker_diagnosis_ns 32716219 hsa-mir-296a Coronary Artery Disease Concerning positive relationship between miRNA 296-a gene expression level and serum concentrations of IL-6 and TNF-alpha in CAD patients, it is proposed that IL-6 and TNF-alpha inhibitor could be the main targets of miRNA 296a and, thereby the IL-6 and TNF-alpha levels were increased; however, further study is needed. +lncRNA target 32716147 hsa-mir-625 Adenocarcinoma of Lung CONCLUSIONS: The present study showed that LINC00511 was involved in LAC progression by targeting miR +other 32715738 hsa-mir-210 Glioma Conclusion: Expression of miR-210 may predict poor survival in patients with glioma. +other 32714975 hsa-mir-1291 Esophageal Squamous Cell Carcinoma Survival analysis revealed that 85 DEMs were related to prognosis, among which hsa-miR-1248, hsa-miR-1291, hsa-miR-421, and hsa-miR5p were used for a prognostic survival model. +other 32714975 hsa-mir-7 Esophageal Squamous Cell Carcinoma Survival analysis revealed that 85 DEMs were related to prognosis, among which hsa-miR-1248, hsa-miR-1291, hsa-miR-421, and hsa-miR5p were used for a prognostic survival model. +other 32714975 hsa-mir-421 Esophageal Squamous Cell Carcinoma Survival analysis revealed that 85 DEMs were related to prognosis, among which hsa-miR-1248, hsa-miR-1291, hsa-miR-421, and hsa-miR5p were used for a prognostic survival model. +other 32714975 hsa-mir-1248 Esophageal Squamous Cell Carcinoma Survival analysis revealed that 85 DEMs were related to prognosis, among which hsa-miR-1248, hsa-miR-1291, hsa-miR-421, and hsa-miR5p were used for a prognostic survival model. +lncRNA target 32714925 hsa-mir-221 Asthma CONCLUSION: miR-221 might play a crucial role in the mechanism of remodeling via the PI3K/AKT pathway in chronic asthma and it could be considered as a potential target for developing therapeutic strategies. +transcription factor target 32714925 hsa-mir-221 Pneumonia RESULTS: The inhibition of miR-221 in a murine asthma model was found to reduce airway hyper-responsiveness, mucus metaplasia, airway inflammation, and airway remodeling (p < 0.05). +transcription factor target 32714925 hsa-mir-221 Cystic Fibrosis RESULTS: The inhibition of miR-221 in a murine asthma model was found to reduce airway hyper-responsiveness, mucus metaplasia, airway inflammation, and airway remodeling (p < 0.05). +transcription factor target 32714583 hsa-mir-181a Parkinson Disease miR-181a has been shown to be dysregulated in PD patients, and has been identified as a potential biomarker for PD. These data describe a new role for miR-181a in mDA neurons, and provide proof of principle that miR-181a dysresgulation in PD may alter the activation state of signalling pathways important for neuronal growth in neurons affected in PD. +genetics_GWAS 32714372 hsa-mir-200a Thyroid Neoplasms Finally, we introduced a case study, enhancer: chr1:1186391-1186507 approximately miR-200a was highly relevant to the survival of thyroid cancer patients and a cis-eQTL SNP on the enhancer affected the expression of the TNFRSF18 gene as a tumor suppressor. +genetics_overexpression_promote 32714149 hsa-mir-124 Citrullinemia Collectively, these results show that overexpression of miR-124 in SCs promotes SC-AS integration in vitro and may attenuate the capacity of ASs to form glial scars. +other 32714145 hsa-mir-497 Nervous System Diseases 5p/BDNF axis was validated to be an important signaling pathway in modulating ketamine-induced neural injury. +target gene 32714095 hsa-mir-106a Ovarian Neoplasms Circular RNA ITCH suppresses proliferation, invasion, and glycolysis of ovarian cancer cells by up-regulating CDH1 via sponging miR-106a. +lncRNA target 32714094 hsa-mir-7 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma CONCLUSIONS: LncRNA ANRIL can modulate malignant phenotypes of T-ALL cells, possibly by regulating miR5p/TCF4 axis, and it serves as a potential therapeutic target for T-ALL. +genetics_knock down_promote 32714093 hsa-mir-7 Prostatic Neoplasms Both hsa_circ_0000735 knockdown and miR-7 mimic boosted DTX sensitivity, constrained viability, colony formation, cell cycle progression, and fostered apoptosis of DTX-resistant PCa cells. +other 32714042 hsa-mir-200b Carcinoma, Hepatocellular We observed that the levels of miR-424, let-7c, miR-222, miR-200b were upregulated when hepatoma cells were treated with MG132, and this increase was negatively correlated with the levels of PBX3. +other 32714042 hsa-mir-222 Carcinoma, Hepatocellular We observed that the levels of miR-424, let-7c, miR-222, miR-200b were upregulated when hepatoma cells were treated with MG132, and this increase was negatively correlated with the levels of PBX3. +other 32714042 hsa-mir-424 Carcinoma, Hepatocellular We observed that the levels of miR-424, let-7c, miR-222, miR-200b were upregulated when hepatoma cells were treated with MG132, and this increase was negatively correlated with the levels of PBX3. +other 32714042 hsa-let-7c Carcinoma, Hepatocellular We observed that the levels of miR-424, let-7c, miR-222, miR-200b were upregulated when hepatoma cells were treated with MG132, and this increase was negatively correlated with the levels of PBX3. +genetics_overexpression_suppress 32713934 hsa-mir-133a Parkinson Disease CONCLUSIONS Our data highlighted that miR-133a overexpression prevented apoptosis and autophagy in a cell model of MPP(+)-induced PD by inhibiting RAC1 expression. +lncRNA target 32713852 hsa-mir-155 Colitis These results suggest that miR-155 contributes to DSS-induced colitis by promoting intestinal barrier dysfunction and inhibiting the HIF-1alpha/TFF-3 axis. +lncRNA target 32713345 hsa-mir-506 Colorectal Neoplasms As a result, circPACRGL promoted CRC cell proliferation, migration and invasion, as well as differentiation of N1 to N2 neutrophils via miR +lncRNA target 32713345 hsa-mir-142 Colorectal Neoplasms As a result, circPACRGL promoted CRC cell proliferation, migration and invasion, as well as differentiation of N1 to N2 neutrophils via miR +genetics_overexpression_promote 32713344 hsa-mir-140 Thyroid Neoplasms Overexpression of miR-140 inhibited cell proliferation, migration, and invasion of thyroid cancer. +other 32713252 hsa-mir-9 Alzheimer Disease Our results showed miR5p may play a powerful role in the pathogenesis of AD. +lncRNA target 32713242 hsa-mir-135b Inflammation CONCLUSION: The study highlights that up regulation of miR-135b-5p can reduce neuronal injury and inflammatory response in PSCI by targeting NR3C2, which might be helpful for PSCI treatment. +lncRNA target 32713242 hsa-mir-135b Postoperative Cognitive Complications CONCLUSION: The study highlights that up regulation of miR-135b-5p can reduce neuronal injury and inflammatory response in PSCI by targeting NR3C2, which might be helpful for PSCI treatment. +circulation_biomarker_diagnosis_ns 32713026 hsa-mir-15b Pulmonary Disease, Chronic Obstructive CONCLUSIONS: Circulating miR-15b-5p is a potential marker for identifying patients with ACO. +other 32713026 hsa-mir-26b Asthma Five of these miRNAs (miR-148a-3p, miR-15b-5p, miR3p, miR-23a-3p, and miR-26b-5p) had lower levels in ACO patients and could discriminate between ACO patients and patients with either asthma or COPD. +other 32713026 hsa-mir-223 Asthma Five of these miRNAs (miR-148a-3p, miR-15b-5p, miR3p, miR-23a-3p, and miR-26b-5p) had lower levels in ACO patients and could discriminate between ACO patients and patients with either asthma or COPD. +other 32713026 hsa-mir-223 Pulmonary Disease, Chronic Obstructive Five of these miRNAs (miR-148a-3p, miR-15b-5p, miR3p, miR-23a-3p, and miR-26b-5p) had lower levels in ACO patients and could discriminate between ACO patients and patients with either asthma or COPD. +other 32713026 hsa-mir-23a Pulmonary Disease, Chronic Obstructive Five of these miRNAs (miR-148a-3p, miR-15b-5p, miR3p, miR-23a-3p, and miR-26b-5p) had lower levels in ACO patients and could discriminate between ACO patients and patients with either asthma or COPD. +other 32713026 hsa-mir-148a Pulmonary Disease, Chronic Obstructive Five of these miRNAs (miR-148a-3p, miR-15b-5p, miR3p, miR-23a-3p, and miR-26b-5p) had lower levels in ACO patients and could discriminate between ACO patients and patients with either asthma or COPD. +circulation_biomarker_diagnosis_ns 32713026 hsa-mir-15b Asthma CONCLUSIONS: Circulating miR-15b-5p is a potential marker for identifying patients with ACO. +other 32713026 hsa-mir-148a Asthma Five of these miRNAs (miR-148a-3p, miR-15b-5p, miR3p, miR-23a-3p, and miR-26b-5p) had lower levels in ACO patients and could discriminate between ACO patients and patients with either asthma or COPD. +other 32713026 hsa-mir-23a Asthma Five of these miRNAs (miR-148a-3p, miR-15b-5p, miR3p, miR-23a-3p, and miR-26b-5p) had lower levels in ACO patients and could discriminate between ACO patients and patients with either asthma or COPD. +other 32713026 hsa-mir-26b Pulmonary Disease, Chronic Obstructive Five of these miRNAs (miR-148a-3p, miR-15b-5p, miR3p, miR-23a-3p, and miR-26b-5p) had lower levels in ACO patients and could discriminate between ACO patients and patients with either asthma or COPD. +lncRNA target 32712875 hsa-mir-29c Alzheimer Disease In conclusion, our findings confirmed that miR-29c-3p attenuated Abeta-induced neurotoxicity through regulation of NF-kappaB signaling pathway by directly targeting TNFAIP1, providing the potential value for the treatment of AD patients. +circulation_biomarker_prognosis_ns 32712720 hsa-mir-768 Carcinoma, Hepatocellular ROC curve suggested that serum miR +circulation_biomarker_diagnosis_ns 32712618 hsa-mir-503 Hypertension, Pulmonary MiR-503 is underexpressed in plasma and hPASMCs of patients with PAH. +genetics_knock down_promote 32712290 hsa-mir-375 Uterine Cervical Neoplasms Mechanistically, knockdown of miR-375 significantly reversed the anti-cancer effect of calycosin on CC cells. +transcription factor target 32712160 hsa-mir-381 psoriasis 1 3p to CD4(+)T cells through sEVs, inducing Th1 and Th17 polarization and promoting psoriasis development. +transcription factor target 32712053 hsa-mir-424 Pulmonary Fibrosis Thus, targeting miR-424 may provide a new therapeutic strategy to prevent myofibroblast differentiation and IPF progression. +other 32712053 hsa-mir-424 Fibrosis Quantitative RT-PCR confirmed that miR-424 expression was increased by 2.6-fold in HLFs in response to TGF-beta1 and was 1.7-fold higher in human fibrotic lung tissues as compared to non-fibrotic lung tissues. Together, these data demonstrate a pro-fibrotic role of miR-424 in TGF-beta1-induced HLF differentiation. +exosome 32712030 hsa-mir-124 Amyotrophic Lateral Sclerosis These results provide preliminary evidence to support the potential use of CSF exosomal miR +lncRNA target 32712019 hsa-mir-1 Cholangitis, Sclerosing, Primary Targeting the SP/NK1R and/or miR-31 may be a potential approach in treating human cholangiopathies, including primary sclerosing cholangitis. +lncRNA target 32712019 hsa-mir-1 Liver Cirrhosis Targeting the SP/NK1R and/or miR-31 may be a potential approach in treating human cholangiopathies, including primary sclerosing cholangitis. +other 32711895 hsa-mir-208a Heart Failure CONCLUSION: Use of miR-208a in combination with NT-proBNP may allow a more reliable method in diagnosing HFrEF patients. +genetics_overexpression_promote 32711584 hsa-mir-216a Ovarian Neoplasms CTBP1-AS2 and PTEN overexpression resulted in the reduced proliferation rate of OC cells and reduced effects of miR-216a overexpression. +other 32711415 hsa-mir-140 Breast Neoplasms The current study aimed at the analysis of miR-140 and miR-196a expression patterns and their clinical significance for breast cancer (BC) patients. +transcription factor target 32711415 hsa-mir-196a Breast Neoplasms METHODS: Differentially expressed miR-140 and miR-196a were examined via quantitative PCR in 110 cases of BC and their adjacent non-tumor (ANT) tissues. +target gene 32711380 hsa-mir-873 Breast Neoplasms Transcriptional Factor Yin Yang 1 Promotes the Stemness of Breast Cancer Cells by Suppressing miR-873-5p Transcriptional Activity. +lncRNA target 32711110 hsa-mir-134 Carcinoma, Hepatocellular 5p/FOXM1 may serve as a novel target for HCC treatment. +transcription factor target 32711096 hsa-mir-495 Glioblastoma Dual-luciferase reporter assays demonstrated that LGMN was a target of miR +other 32711022 hsa-mir-4465 Breast Neoplasms Expression level of VLDL receptor and VLDL-c levels in the malignant and benign breast tumors: The correlation with miRNA-4465 and miRNA-1297. These data revealed that the lower expression of VLDLR mediated by the high expression levels of miRNA-4465 may be involved in the development of breast cancer. +circulation_biomarker_prognosis_up 32710946 hsa-mir-135b Stomach Neoplasms The miR-135b level in the plasma of gastric cancer patients was significantly higher than that in healthy individuals. +transcription factor target 32710726 hsa-mir-135a Carcinoma, Non-Small-Cell Lung In summary, miR-135a might function as a suppressor of NSCLC cells, and thus could be used as a potential therapeutic target. +circulation_biomarker_prognosis_up 32710681 hsa-mir-24 Diabetic Foot To examine the correlations of miR-24 expression in peripheral plasma with the onset of diabetic foot ulcer (DFU) and diabetic foot osteomyelitis (DFO) in type 2 diabetes mellitus (T2DM) patients and explore the clinical value of miR-24 as a potential biomarker for the diagnosis and treatment outcomes of DFU and DFO, a total of 60 newly diagnosed T2DM patients without DFU (T2DM group), 112 T2DM patients with DFU (DFU group), and 60 healthy controls (NC group) were included. +circulation_biomarker_prognosis_up 32710681 hsa-mir-24 Diabetes Mellitus, Type 2 To examine the correlations of miR-24 expression in peripheral plasma with the onset of diabetic foot ulcer (DFU) and diabetic foot osteomyelitis (DFO) in type 2 diabetes mellitus (T2DM) patients and explore the clinical value of miR-24 as a potential biomarker for the diagnosis and treatment outcomes of DFU and DFO, a total of 60 newly diagnosed T2DM patients without DFU (T2DM group), 112 T2DM patients with DFU (DFU group), and 60 healthy controls (NC group) were included. +transcription factor target 32710569 hsa-mir-451a Cholangiocarcinoma In addition, we identified miR-451a and miR3p as putative tumour suppressors attenuating cell migration by inhibiting ATF2 in the process of dCCA tumorigenesis. +transcription factor target 32710569 hsa-mir-144 Cholangiocarcinoma In addition, we identified miR-451a and miR3p as putative tumour suppressors attenuating cell migration by inhibiting ATF2 in the process of dCCA tumorigenesis. +genetics_GWAS 32710451 hsa-mir-27a Colorectal Neoplasms This study was aimed to investigate the role of miR-27a rs895819 polymorphism on CRC risk in Chinese population. CONCLUSION: Our study suggests that miR-27a rs895819 polymorphism plays an important role in CRC risk in Chinese population and may serve as a valuable biomarker for predicting an individual's susceptibility to CRC. +lncRNA target 32710276 hsa-mir-146b Lupus Nephritis NEAT1 accelerated renal mesangial cell injury via directly targeting miR-146b, promoting the expression of TRAF6, and activating the NF-kappaB signaling in lupus nephritis. +genetics_GWAS 32710190 hsa-let-7e Diabetes Mellitus, Type 2 A second epigenetic mechanism, upregulation of hepatic miRNA hsa-let-7e-5p (let-7e-5p) in obese individuals with type 2 diabetes (n=29) vs non-diabetic obese individuals (n=49) (1.20.08-fold change; p=0.0332; pa=0.0450), is likely to act synergistically with altered IRS2 DNA methylation to decrease IRS2 expression. +genetics_GWAS 32710190 hsa-let-7e Obesity A second epigenetic mechanism, upregulation of hepatic miRNA hsa-let-7e-5p (let-7e-5p) in obese individuals with type 2 diabetes (n=29) vs non-diabetic obese individuals (n=49) (1.20.08-fold change; p=0.0332; pa=0.0450), is likely to act synergistically with altered IRS2 DNA methylation to decrease IRS2 expression. +other 32710189 hsa-mir-34c Corneal Diseases Protective effects of autophagy activators were demonstrated, including rapamycin for DED and keratitis, lithium for FECD, LYN-1604 for DED, cysteamine and miR-34c antagomir for damaged corneal epithelium. +lncRNA target 32709878 hsa-mir-34a Heart Injuries The findings strongly suggested that the PD-1 inhibitor exerted its effect in promoting M1 polarization and cardiac injury by modulating the miR-34a/KLF4-signaling pathway and inducing myocardial inflammation. +other 32709857 hsa-mir-548c Osteosarcoma MiR-548c-3p was the sponge miRNA of LINC00266-1, which was able to reverse the regulatory effects of LINC00266-1 on OS cell phenotypes. Finally, we have identified that LINC00266-1/miR-548c-3p/SMAD2 feedback loop was responsible for stimulating the development of OS. +genetics_overexpression_suppress 32709240 hsa-mir-541 Osteosarcoma CONCLUSION: The results of this study revealed that the decreased miR-541 expression in OS patients may serve as a prognostic biomarker, and that the overexpression of miR-541 in OS cells results in inhibited cell proliferation, migration and invasion, indicating the potential of miR-541 as a therapeutic target in OS treatment. +transcription factor target 32709223 hsa-mir-410 Osteoarthritis 3p/ HMGB1 as therapeutic targets for OA treatment. +lncRNA target 32709089 hsa-let-7e Carcinoma, Hepatocellular Finally, the analysis of 374 HCC samples in comparison to 50 normal liver tissues showed an upregulation of SP-AS and a reverse expression of miR-125a, not observed for let-7e; consistently, miR-125a oncogenic targets were upregulated. +lncRNA target 32709089 hsa-mir-125a Carcinoma, Hepatocellular Finally, the analysis of 374 HCC samples in comparison to 50 normal liver tissues showed an upregulation of SP-AS and a reverse expression of miR-125a, not observed for let-7e; consistently, miR-125a oncogenic targets were upregulated. +lncRNA target 32708601 hsa-mir-203a Inflammatory Breast Neoplasms Intriguingly, qPCR revealed that the expression of zinc finger E box-binding homeobox 2 (ZEB2) mRNA, the putative target of miR-200b-3p, miR-200c-3p, and miR-203a-3p, was upregulated in IBC tumors. +genetics_overexpression_suppress 32708470 hsa-mir-22 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 3p overexpression in T-ALL cells can inhibit colony formation in vitro and leukemia progression in vivo. +lncRNA target 32708433 hsa-mir-145 Adenocarcinoma of Lung 5p by miRNA inhibitors increases the expression of CP and VEGF-A in lung cancer cells. +circulation_biomarker_diagnosis_up 32708301 hsa-mir-133a Pulmonary Disease, Chronic Obstructive Among them, miR-206, miR-133a-5p, and miR-133a-3p are striated muscle-specific miRNAs (myo-miRNA), related to skeletal muscle dysfunction, one of the commonest systemic manifestations in patients with chronic obstructive pulmonary disease (COPD). Our data provide evidence that myo-miRNA are present in EV in the plasma of COPD patients and their expression (miR-206, miR-133a-5p, and miR-133a-3p) can discriminate group B from group C patients. +circulation_biomarker_diagnosis_up 32708301 hsa-mir-206 Pulmonary Disease, Chronic Obstructive Among them, miR-206, miR-133a-5p, and miR-133a-3p are striated muscle-specific miRNAs (myo-miRNA), related to skeletal muscle dysfunction, one of the commonest systemic manifestations in patients with chronic obstructive pulmonary disease (COPD). Our data provide evidence that myo-miRNA are present in EV in the plasma of COPD patients and their expression (miR-206, miR-133a-5p, and miR-133a-3p) can discriminate group B from group C patients. +transcription factor target 32708220 hsa-mir-200b Gastrointestinal Stromal Tumors 3p and miR-200b-3p have a tumor-suppressive role in GIST. +other 32708088 hsa-mir-107 Stomach Neoplasms Our results indicate that circHIPK3/miR-107/BDNF/LIN28 axis may mediate chemoresistance in GC, and that circPVT1, circHIPK3, circNF1, ciRS-7 and circ_0000096 appear to be involved in gastrointestinal cancer development. +genetics_overexpression_promote 32707933 hsa-mir-526b Breast Neoplasms Previously, we have shown that overexpression of oncogenic microRNAs (miRNAs, miRs) miR526b/miR655 in poorly metastatic breast cancer cell lines promotes aggressive cancer phenotypes in vitro and in vivo. +genetics_overexpression_promote 32707933 hsa-mir-655 Breast Neoplasms Previously, we have shown that overexpression of oncogenic microRNAs (miRNAs, miRs) miR526b/miR655 in poorly metastatic breast cancer cell lines promotes aggressive cancer phenotypes in vitro and in vivo. +other 32707301 hsa-mir-149 Diabetes Mellitus miR5p has been identified in several diseases including diabetes. +lncRNA target 32707301 hsa-mir-149 Norrie disease Thus, it was revealed that circ_0123996 was involved in DN via sponging miR +lncRNA target 32707301 hsa-mir-149 Vascular Diseases BTB and CNC homology 1 (Bach1) is reported in various disease including some vascular diseases.Here, Bach1 was confirmed as a target of miR5p. +lncRNA target 32707301 hsa-mir-149 Fibrosis Circ_0123996 upregulated Bach1 expression and restrained MMCs proliferation and fibrosis through sponging miR5p. +transcription factor target 32707150 hsa-mir-424 Brain Ischemia The results revealed that inhibition of miR5p markedly reduced neurological dysfunctions and endothelial cell injury induced by MCAO. +lncRNA target 32707074 hsa-mir-29b Heart Diseases Taken together, our findings demonstrate that upregulation of miR-29b-3p can attenuate myocardial injury induced by sepsis via regulating FOXO3A, which provide a potential therapy target for interference of septic cardiac dysfunction. +lncRNA target 32707074 hsa-mir-29b Inflammation miR-29b-3p ameliorates inflammatory damage likely via reducing activation of MAPKs and nuclear-translocation of NF-kappaB to block LPS-activated NF-kappaB signaling. +circulation_biomarker_diagnosis_up 32707074 hsa-mir-29b Sepsis Notably, miR-29b is also down-regulated in septic patients' plasma compared with normal subjects, indicating a potential clinical relevance of miR-29b. Taken together, our findings demonstrate that upregulation of miR-29b-3p can attenuate myocardial injury induced by sepsis via regulating FOXO3A, which provide a potential therapy target for interference of septic cardiac dysfunction. +genetics_overexpression_promote 32707073 hsa-mir-9 Glioblastoma The overexpression of miR-9 suppressed the cell proliferation and aerobic glycolysis of glioma cells. CONCLUSIONS: In conclusion, ANXA2P2/miR-9/LDHA axis modulates the aerobic glycolysis progression in glioma cells, therefore affecting glioma cell proliferation. +transcription factor target 32707034 hsa-mir-342 Inflammation Our results uncover a previously unknown contribution of Treg cells during glucocorticoid-mediated treatment of inflammation and the underlying mechanisms operated via the Dex-miRRictor axis. +transcription factor target 32707001 hsa-mir-92a Wounds and Injuries MRG-110 is a locked nucleic acid-based antisense oligonucleotide that targets miR-92a-3p and experimentally was shown to have documented therapeutic effects on cardiovascular disease and wound healing. +genetics_knock down_promote 32706998 hsa-mir-32 Osteosarcoma 5p knockdown overturned the effects of HNF1A-AS1 knockdown on apoptosis, proliferation, migration, and invasion of OS cells. +circRNA target 32706759 hsa-mir-145 Osteosarcoma 3p-mediated NRAS inhibition. +circRNA target 32706759 hsa-mir-151 Osteosarcoma 3p-mediated NRAS inhibition. +genetics_overexpression_promote 32706318 hsa-mir-340 Arthritis, Rheumatoid Overexpression of STAT3 could reverse the outcome of microRNA +other 32706196 hsa-mir-211 Alzheimer Disease 5p in the rat model or in vitro model of a sporadic type of Alzheimer's disease. +lncRNA target 32706194 hsa-mir-29b Brain Ischemia Analysis of microRNAs sequencing revealed that the expression of microRNA-27a-5p was induced, and microRNA-29b-3p expression was inhibited in neuroblastoma cells exposed to oxygen-glucose deprivation and reoxygenation. +lncRNA target 32706194 hsa-mir-27a Brain Ischemia Analysis of microRNAs sequencing revealed that the expression of microRNA-27a-5p was induced, and microRNA-29b-3p expression was inhibited in neuroblastoma cells exposed to oxygen-glucose deprivation and reoxygenation. +lncRNA target 32706167 hsa-mir-497 Breast Neoplasms Overall, our work reveals the miR-497/IRAK2/NF-kappaB axis as a vital mechanism of canine mammary tumour progression and suggests this axis as a target in breast cancer. +circRNA target 32706154 hsa-mir-761 Colorectal Neoplasms More importantly, hsa_circRNA_102209/miR-761/RIN1 signaling may be a novel therapeutic target for the treatment of CRC patients. +other 32706136 hsa-let-7 Pulmonary Fibrosis In conclusion, RILF occurred when GSK-3beta/TGF-beta1 signaling increased beta-catenin levels, which led to the augmentation of AEC II population by elevated lin28/let-7 ratio and the transcription of profibrotic cytokines and factors, thereby inducing AEC II to undergo transdifferentiation into mesenchymal cells. +circRNA target 32706069 hsa-mir-715 Lung Neoplasms CONCLUSIONS: In this study, we found that circRNA_010763 was highly expressed in human NSCLC tissues, which could promote tumor proliferation, migration and invasion through serving as a molecular sponge by modulating the inhibitory effect of miR-715 on oncogene c-Myc. +circulation_biomarker_prognosis_up 32706068 hsa-mir-148a Breast Neoplasms CONCLUSIONS: Our data have demonstrated that serum exosomal miR-148a is significantly reduced in patients with BC and downregulation of serum exosomal miR-148a is closely associated with unfavorable clinical outcome of BC, indicating that serum exosomal miR-148a might serve as a promising diagnostic and prognostic biomarker for BC. +lncRNA target 32706064 hsa-mir-24 Ovarian Neoplasms Our results verified that OIP5-AS1 inhibited the expression of miR +lncRNA target 32706063 hsa-mir-616 Ovarian Neoplasms 5p/GSK3beta/beta-catenin pathway, which might provide a novel promising therapeutic target for ovarian cancer. +other 32706032 hsa-mir-636 Aortic Dissection CONCLUSIONS Hsa-miR-636 is involved in the pathogenesis of AAD and may be a potential biomarker for this disease. +other 32705492 hsa-mir-34c Diabetic Nephropathies CONCLUSION: LINC00667 could reduce the proliferation and invasion of chronic kidney disease cells, increase the apoptosis rate by regulating miR-34c, and improve renal fibrosis. +other 32705446 hsa-mir-1 Gastric Intestinal Metaplasia CONCLUSIONS: Our findings show that the HDAC6/HNF4alpha loop regulated by miR-1 plays a critical role in gastric IM. +other 32705287 hsa-mir-939 Prostatic Neoplasms In addition, it was observed that BCYRN1 directly sponged miR9393p to upregulate histone deacetylase 11 (HDAC11) expression in prostate cancer cells. +circulation_biomarker_diagnosis_ns 32705283 hsa-mir-27a Osteoporosis miR27a3p level was significantly decreased during osteogenic differentiation and increased in the serum of patients with osteoporosis. Together, miR27a3p contributed to diminished osteogenic function during osteogenic differentiation and might thus serve as a therapeutic target and diagnostic biomarker for osteoporosis. +other 32705274 hsa-mir-30 Bicuspid Aortic Valve Disease Collectively, miR3303p was upregulated in calcified BAV compared with TAV. +genetics_knock down_promote 32705273 hsa-mir-135a Diabetic Nephropathies Knockdown of miR135a5p and overexpression of SIRT1 could inhibit TGFbeta1induced renal fibrosis in vitro. In conclusion, knockdown of miR135a5p inhibits TGFbeta1induced renal fibrosis by targeting SIRT1 and inactivating Smad3 signaling, providing a novel insight into miR135a5p as a potential therapeutic approach for DN. +genetics_knock down_promote 32705273 hsa-mir-135a Fibrosis, Renal Knockdown of miR135a5p and overexpression of SIRT1 could inhibit TGFbeta1induced renal fibrosis in vitro. In conclusion, knockdown of miR135a5p inhibits TGFbeta1induced renal fibrosis by targeting SIRT1 and inactivating Smad3 signaling, providing a novel insight into miR135a5p as a potential therapeutic approach for DN. +genetics_knock down_promote 32705261 hsa-mir-98 Lung Neoplasms In conclusion, ANRIL knockdown inhibited the development of DDP resistance by upregulating miR98, providing novel insights into the molecular mechanism of ANRIL involvement in DDP resistance of lung cancer cells. +genetics_GWAS 32705257 hsa-mir-125b Ovarian Neoplasms In conclusion, the present study demonstrated that the mutation located in GAPDH 3'UTR promoted OVCA growth and development by sponging miR125b and thereby affecting STAT3 expression levels. +transcription factor target 32705253 hsa-mir-532 Reperfusion Injury, Cerebral Ischemia Collectively, these data indicated that miR5323p may be a target of NOX2 and a biomarker for CI/R injury. +lncRNA target 32705244 hsa-mir-142 Pancreatic Carcinoma These findings suggest that miR1425p may be a novel therapeutic target for the treatment of pancreatic cancer. +lncRNA target 32705237 hsa-mir-16 Prostatic Neoplasms Moreover, luciferase reporter assay and western blot analysis showed that miR165p directly targets AKT3 (AKT serine/threonine kinase 3), which is associated with PCa carcinogenesis, and the effects of the downregulation of AKT3 were similar to the effects of upregulation of miR165p in PC3 cells. +lncRNA target 32705233 hsa-mir-27b Glioma lncRNA titinantisense RNA1 (TTNAS1), miR27b3p and Runtrelated transcription factor 1 (RUNX1) expression in glioma tissues and cell lines was estimated by RTqPCR. In conclusion, the present study supported that TTNAS1 acts as an oncogene in glioma by targeting miR27b3p to release RUNX1. +genetics_knock down_promote 32705215 hsa-mir-590 Reperfusion Injury It was demonstrated that ZFAS1 was upregulated and miR5903p was downregulated in the in vitro model of cardiac I/R injury. Collectively, the present results suggested that ZFAS1 was upregulated in H9c2 cells subjected to I/R injury, and that ZFAS1 knockdown protected against I/Rinduced myocardial cell apoptosis by directly interacting with miR5903p, via the NFkappaB pathway. +other 32705215 hsa-mir-590 Heart Diseases It was demonstrated that ZFAS1 was upregulated and miR5903p was downregulated in the in vitro model of cardiac I/R injury. +genetics_knock down_promote 32705215 hsa-mir-590 Iron Metabolism Disorders It was demonstrated that ZFAS1 was upregulated and miR5903p was downregulated in the in vitro model of cardiac I/R injury. Collectively, the present results suggested that ZFAS1 was upregulated in H9c2 cells subjected to I/R injury, and that ZFAS1 knockdown protected against I/Rinduced myocardial cell apoptosis by directly interacting with miR5903p, via the NFkappaB pathway. +lncRNA target 32705210 hsa-mir-193a Thyroid Neoplasms miRWalk 3.0, and the TCGA and GEO databases were used to predict the candidate target genes of miR193a3p. +genetics_knock down_promote 32705201 hsa-mir-199a Colorectal Neoplasms In addition, the immunofluorescence assay suggested that miR199a5p mimics suppressed the EMT of CRC cells, whereas the overexpression of ITGA3 restored this effect. +transcription factor target 32705191 hsa-mir-204 ankylosing spondylitis 1 Furthermore, miR2045p inhibited the osteogenic differentiation of ligament fibroblasts in patients with AS by targeting Notch2. +transcription factor target 32705174 hsa-mir-486 Inflammation To conclude, inhibition of miR4865p alleviated LPSinduced cell damage, including inflammatory injury, oxidative stress and apoptosis, in ATDC5 cells by targeting NRF1. +lncRNA target 32705173 hsa-mir-335 Diabetes Mellitus, Type 2 Notably, hsamiR1925p, hsamiR1245p and hsamiR3355p appeared to be involved in T2DM by potentially regulating the expression of various candidate genes, including procollagen Cendopeptidase enhancer 2, connective tissue growth factor and family with sequence similarity 105, member A, protein phosphatase 1 regulatory inhibitor subunit 1 A and CC motif chemokine receptor 4. +lncRNA target 32705173 hsa-mir-124 Diabetes Mellitus, Type 2 Notably, hsamiR1925p, hsamiR1245p and hsamiR3355p appeared to be involved in T2DM by potentially regulating the expression of various candidate genes, including procollagen Cendopeptidase enhancer 2, connective tissue growth factor and family with sequence similarity 105, member A, protein phosphatase 1 regulatory inhibitor subunit 1 A and CC motif chemokine receptor 4. +lncRNA target 32705173 hsa-mir-192 Diabetes Mellitus, Type 2 Notably, hsamiR1925p, hsamiR1245p and hsamiR3355p appeared to be involved in T2DM by potentially regulating the expression of various candidate genes, including procollagen Cendopeptidase enhancer 2, connective tissue growth factor and family with sequence similarity 105, member A, protein phosphatase 1 regulatory inhibitor subunit 1 A and CC motif chemokine receptor 4. +genetics_overexpression_promote 32705168 hsa-mir-589 Breast Neoplasms The target gene of miR5893p was predicted and verified by TargetScan and dualluciferase reporter assay, and the mechanism of miR5893p involvement in breast cancer cells was explored by overexpression or downregulation of miR5893p in breast cancer cells. +other 32705167 hsa-mir-29c Cranial Nerve Injuries A significant decrease in the expression of spinal microRNA29c (miR29c), which is responsible for the regulation of oxytocin receptor (OXTR) expression, was observed in nerve injury pain during childbirth. +lncRNA target 32705167 hsa-mir-29c Pain Silencing spinal miR29c may be a potential target for pain relief through the OTGABA pathway. +other 32705167 hsa-mir-29c Leigh Disease The increased expression of OXTR and GABA in delivery+SNI rats were observed in the miR29csilenced SNI rat model, suggesting that the silencing of miR29c can mediate pain relief by enhancing the OTGABA pathway. +genetics_knock down_promote 32705162 hsa-mir-193a Leukemia The downregulation of miR193a5p enhanced the viability of the leukemia cells, accelerated cell cloning and reduced cell apoptosis, which was completely opposite to the effects observed with the silencing of CDK8. The knockdown of SNHG16 suppressed the viability of the leukemia cells, suppressed cell proliferation, and induced cell apoptosis by regulating miR193a5p/CDK8. +circRNA target 32705161 hsa-mir-19b Urinary Bladder Neoplasms Taken together, our findings indicate that circRNA0071196 upregulates CIT levels in BCa by sponging off miRNA19b3p, and the circRNA_0071196/miRNA19b3p/CIT axis is a potential therapeutic target in BCa. +genetics_knock down_promote 32705160 hsa-mir-4458 Carcinoma, Hepatocellular In addition, miR4458 was identified as a target of HOXA11AS, and miR4458 inhibition reversed the effect of HOXA11AS knockdown on HCC cell progression. +lncRNA target 32705159 hsa-mir-144 Multiple Myeloma On the whole, the findings of the present study demonstrate that miR1443p exerts antitumour effects by downregulating MEF2A to inhibit the proliferation, migration and angiogenesis of MM cells. +lncRNA target 32704465 hsa-mir-221 Thyroid Cancer, Papillary We suggested that miR-221/222 can promote migration and invasion, and inhibit autophagy and apoptosis by targeting ATG10 in APTC. +other 32704163 hsa-mir-520g Carcinoma, Hepatocellular Here we show that, a network of C19MC miRNA-520G, IFN-gamma, CEBPB and p53 transcriptional-defects promote MYO18B mRNA expression in HCCs. +lncRNA target 32704131 hsa-mir-34a Heart Diseases Results indicate that in our model systemic administration of Ant34a completely silences miR-34a myocardial expression and importantly attenuates DOXO-induced cardiac dysfunction. Ant34a systemic delivery in DOXO-treated rats triggers an upregulation of prosurvival miR-34a targets Bcl-2 and SIRT1 that mediate a reduction of DOXO-induced cardiac damage represented by myocardial apoptosis, senescence, fibrosis and inflammation. +lncRNA target 32704131 hsa-mir-34a Fibrosis Ant34a systemic delivery in DOXO-treated rats triggers an upregulation of prosurvival miR-34a targets Bcl-2 and SIRT1 that mediate a reduction of DOXO-induced cardiac damage represented by myocardial apoptosis, senescence, fibrosis and inflammation. +lncRNA target 32704131 hsa-mir-34a Inflammation Ant34a systemic delivery in DOXO-treated rats triggers an upregulation of prosurvival miR-34a targets Bcl-2 and SIRT1 that mediate a reduction of DOXO-induced cardiac damage represented by myocardial apoptosis, senescence, fibrosis and inflammation. +other 32704131 hsa-mir-34a Cardiotoxicity The aim of the present work is to evaluate the potential cardioprotective properties of a specific antimiR-34a (Ant34a) in an experimental model of DOXO-induced cardiotoxicity. +other 32704077 hsa-mir-34a Stomach Neoplasms The expression patterns of seven candidate genes, including -catenin, Notch1, GATA6, CDX2, miR-34a, miR-181a, and miR-93 were determined in 24 paired GC tissues and corresponding non-cancerous tissues by quantitative Real-Time PCR. +other 32704077 hsa-mir-181a Stomach Neoplasms The expression patterns of seven candidate genes, including -catenin, Notch1, GATA6, CDX2, miR-34a, miR-181a, and miR-93 were determined in 24 paired GC tissues and corresponding non-cancerous tissues by quantitative Real-Time PCR. +other 32704077 hsa-mir-93 Stomach Neoplasms The expression patterns of seven candidate genes, including -catenin, Notch1, GATA6, CDX2, miR-34a, miR-181a, and miR-93 were determined in 24 paired GC tissues and corresponding non-cancerous tissues by quantitative Real-Time PCR. +circRNA target 32703944 hsa-mir-133a Nasopharyngeal Carcinoma Colony formation, proliferation, wound healing, transwell, western blot, and in vivo tumor growth and metastasis assays were performed to assess the roles of circ-0046263, miR-133a-5p, IGFBP3 and their interactions in NPC cells. Finally, circ-0046263 plays a tumor-promoting role in NPC to enhance malignant behavior through the miR-133a-5p/IGFBP3 axis, which could be a potential target for NPC therapy. +lncRNA target 32703934 hsa-mir-628 Stomach Neoplasms 5p inhibits the progression of gastric cancer that revered by restoring PIN1 expression. +lncRNA target 32703458 hsa-mir-203a Colorectal Neoplasms Furthermore, LINC00657 worked as a competing endogenous RNA (ceRNA) for miR-203a, antagonizing its function as a tumor suppressor and leading to the de-repression of CSCs invasion. +lncRNA target 32703413 hsa-mir-483 Cartilage Diseases These findings indicate that lncRNA-H19 played a positive role in cartilage degradation in DDH through the lncRNA H19/miR5p/Dusp5 axis. +lncRNA target 32703403 hsa-mir-655 Squamous Cell Carcinoma of Head and Neck Furthermore, we elucidated that LINC01194 promoted SOX18 expression in LSCC cells via functioning as a molecular sponge for miR-655. +other 32703153 hsa-mir-125b-1 Melanoma CONCLUSIONS: The results of this study showed that network motif UCA1/AKT1/hsa-miR-125b-1 has the highest prediction accuracy (ACC = 0.88) for discriminating metastatic and non-metastatic melanoma phenotypes. +other 32703147 hsa-mir-483 Carcinoma, Ovarian Epithelial 5p could also distinguish EOC subtypes between serous EOC and non-serous EOC, with a p < 0.05. +circulation_biomarker_diagnosis_up 32702669 hsa-mir-141 Enterocolitis, Necrotizing 3p was significantly downregulated in serum samples of patients with NEC and LPS-treated Caco-2 cells. +other 32702628 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck miR5p was the one with the greatest accuracy in the differentiation between superficial and deep tumors. +lncRNA target 32702393 hsa-mir-155 Lymphoma, Large B-Cell, Diffuse Inhibition of MiR-155 decreased expression of NFkappaB target genes and sensitized DLBCL cells to ibrutinib, confirming the role of MiR-155 in the modulation of BCR signaling. +other 32701835 hsa-mir-182 Neuralgia Moreover, we found that uc.153 participates in the regulation of neuropathic pain by negatively modulating the processing of pre-miR5p. +lncRNA target 32701359 hsa-mir-7 Carcinoma, Hepatocellular In conclusion, lncRNA RUSC1-AS1 promoted the proliferation and reduced the apoptosis of HCC cells through activation of NOTCH signaling via hsa-miR5p/NOTCH3 axis. +other 32701268 hsa-mir-340 Diabetes Mellitus 5p, was significantly disrupted. +other 32701268 hsa-mir-375 Diabetes Mellitus 5p, was significantly disrupted. +other 32701268 hsa-mir-126 Diabetes Mellitus 5p, was significantly disrupted. +transcription factor target 32701250 hsa-mir-143 Esophageal Squamous Cell Carcinoma 3p and reducing the level of EPS8 in vivo and in vitro, providing promising target for the treatment of esophageal cancer. +genetics_knock down_suppress 32700988 hsa-mir-138 Colorectal Neoplasms Conclusion: These studies disclosed that NEAT1 knockdown inhibited CRC progression by miR-138/SLC38A1 axis, providing an underlying target for CRC treatment. +other 32700888 hsa-mir-135a Atherosclerosis CONCLUSIONS: Our studies revealed the regulatory function of LINC00299/miR-135a-5p/XBP1 axis in AS development, suggesting a potential therapeutic strategy for AS treatment. +transcription factor target 32700754 hsa-mir-223 Colitis Taken together, the results of the present study demonstrated that R.I flagellin inhibited activation of the NLRP3 inflammasome and pyroptosis via miR2233p/NLRP3 signaling in macrophages, suggesting that R.I flagellin may be used as a novel probiotic product for the treatment of UC. +lncRNA target 32700753 hsa-mir-122 Leukemia, Myeloid, Acute On the whole, the findings of the present study demonstrate that ZEB2AS1 promotes cell proliferation and inhibits apoptosis, at least partly by targeting PLK1 mediated by miR1225p in AML cells. +lncRNA target 32700743 hsa-mir-34c Colonic Neoplasms Besides, miR-34c-5p was confirmed to inhibit the cellular process and chemoresistance of colon cancer cells. In conclusion, LINC01123/miR-34c-5p/VEGFA axis promotes colon cancer malignancy and cells chemoresistance. +lncRNA target 32699958 hsa-mir-195 Retinal Diseases Diabetic rats showed up-regulated retinal miR-195, reduced retinal levels of SIRT-1, and increased levels of oxidative stress, nuclear factor-kappaB (NF-kappaB), inflammatory cytokines, and endothelin-1. Oral administration of ISL (20 mg/kg/day) to diabetic rats for 8 weeks improved diabetes-induced retinal injury via down-regulation of miR-195, restoration of retinal SIRT-1 level, attenuation of oxidative stress, inflammation, and endothelial damage as well as preservation of retinal normal histology and ultrastructure. +transcription factor target 32699607 hsa-mir-106b Familial Primary Pulmonary Hypertension Besides, hsa-miR-106b-5p was involved in the development of CTEPH via targeting MMP2. +genetics_overexpression_promote 32699535 hsa-mir-210 Carcinoma, Non-Small-Cell Lung RESULTS: Here, our data showed that miR210HG was overexpressed in NSCLC tissue samples and cells. +lncRNA target 32699532 hsa-mir-1179 Uterine Cervical Neoplasms CONCLUSION: circ_0084927 promoted cervical carcinogenesis by sequestering miR-1179, which directly targeted CDK2. +lncRNA target 32699532 hsa-mir-1179 Hamartoma Syndrome, Multiple Also observed was that miR-1179 directly targeted CDK2, thereby inhibiting CDK2's promotion on the malignant phenotypes of CC cells. +other 32699526 hsa-mir-345 Glioblastoma Mechanistically, LINC01426 serves as a molecular sponge to sequester the miR345-3p and thus enhancing the level of VAMP8, an oncogenic coding gene, to promote GBM progression. +other 32699331 hsa-mir-1827 Alzheimer Disease 3p, miR-1827, miR-940 and miR-30b-3p which were related to AD. +other 32699331 hsa-mir-4722 Alzheimer Disease 3p, miR-1827, miR-940 and miR-30b-3p which were related to AD. +other 32699331 hsa-mir-4768 Alzheimer Disease 3p, miR-1827, miR-940 and miR-30b-3p which were related to AD. +lncRNA target 32699205 hsa-mir-149 Colorectal Neoplasms In summary, our study demonstrated that circCTNNA1 facilitated CC proliferation and invasion via the circCTNNA1/miR5p/FOXM1 axis, and it might function as a novel diagnostic or therapeutic target for patients with CC. +genetics_overexpression_suppress 32698940 hsa-mir-186 Carcinoma, Hepatocellular Overexpression of CDK6 markedly reversed inhibitory effects of miR-186 on proliferation, apoptosis, migration, and invasion of HCC cells. +exosome 32698859 hsa-mir-375 Esophageal Squamous Cell Carcinoma Transfected hUCMSCs-derived exosomes (hUCMSCs-exo) were isolated and co-cultured with ESCC cells to measure the effects of miR-375 delivered by hUCMSCs-exo on ESCC development. +other 32698791 hsa-mir-221 Duane Retraction Syndrome MiR-221, SIRT1 and Nrf2 were associated with apoptosis and proliferation and their expression were altered in DR patients. +genetics_knock down_promote 32698757 hsa-mir-532 Angelman Syndrome 3p-mimic and PAPD5 could attenuate the impact of overexpression of CASC2 on proliferation, migration, and apoptosis in ox-LDL-VSMCs. +other 32698745 hsa-mir-6783 Carcinoma, Hepatocellular CONCLUSION: linc01559 promoted the proliferation of HCC by sponging miR3p. +other 32697411 hsa-mir-122 Kidney Diseases 3pselected as candidates, were explored for their regulatory functions in kidney injury, using NRK-52E cells. +other 32697411 hsa-mir-326 Kidney Diseases 3pselected as candidates, were explored for their regulatory functions in kidney injury, using NRK-52E cells. +genetics_knock down_promote 32697386 hsa-mir-125a Pancreatic Carcinoma In this study, we demonstrated that circRHOT1 was overexpressed in pancreatic cancer tissues and cell lines, and it was found to directly bind to miR-125a-3p, acting as an endogenous sponge to inhibit its activity. Knockdown of circRHOT1 expression significantly inhibited proliferation as well as invasion, and it promoted apoptosis of pancreatic cancer cells via the regulation of E2F3 through the targeting of miR-125a-3p. +genetics_overexpression_promote 32697380 hsa-mir-212 Colorectal Neoplasms 5p overexpression on CRC cell colony formation, invasion, migration and proliferation. +circulation_biomarker_prognosis_ns 32696863 hsa-mir-1204 Breast Neoplasms CONCLUSIONS Detection of tissue and serum miR-1204 levels could have clinical potential as a novel prognostic/diagnostic biomarker for BC patients. +genetics_knock down_suppress 32696822 hsa-mir-770 Diabetic Nephropathies 5p knockdown-mediated improvement of DN is still unclear. +other 32696819 hsa-mir-4251 Myocardial Reperfusion Injury 3p) and therapeutic small molecules like ozone, troglitazone, rosiglitazone, and n-3 polyunsaturated fatty acids for MI/R injury. +other 32696819 hsa-mir-24 Myocardial Reperfusion Injury 3p) and therapeutic small molecules like ozone, troglitazone, rosiglitazone, and n-3 polyunsaturated fatty acids for MI/R injury. +other 32696819 hsa-mir-26b Myocardial Reperfusion Injury 3p) and therapeutic small molecules like ozone, troglitazone, rosiglitazone, and n-3 polyunsaturated fatty acids for MI/R injury. +other 32696819 hsa-mir-2861 Myocardial Reperfusion Injury 3p) and therapeutic small molecules like ozone, troglitazone, rosiglitazone, and n-3 polyunsaturated fatty acids for MI/R injury. +other 32696819 hsa-mir-217 Myocardial Reperfusion Injury 3p) and therapeutic small molecules like ozone, troglitazone, rosiglitazone, and n-3 polyunsaturated fatty acids for MI/R injury. +other 32696819 hsa-mir-124 Myocardial Reperfusion Injury 3p) and therapeutic small molecules like ozone, troglitazone, rosiglitazone, and n-3 polyunsaturated fatty acids for MI/R injury. +other 32696744 hsa-mir-155 Arthritis, Rheumatoid Conclusion In patients with rheumatoid arthritis, lncRNA MALAT1 is reduced and hsa-mir155-3p is raised, which jointly regulate the change of Notch signaling pathway. +genetics_overexpression_promote 32695810 hsa-mir-210 Squamous Cell Carcinoma of Head and Neck 3p was more overexpressed in OSCC tissues than in the JCT. +circulation_biomarker_diagnosis_down 32695627 hsa-mir-532 Atherosclerosis Serum miR +genetics_knock down_promote 32695622 hsa-mir-363 Myocardial Infarction, Acute CONCLUSIONS: Collectively, overexpression of miR +other 32695607 hsa-mir-21 Osteoporotic Fractures All rats were subjected to bilateral bone defects (2 mm diameter) of the proximal tibia and randomly divided into three groups (groups A, B, and C): separately injected with CMCS/n (miR-21), CMCS/n (NC-miR), and saline. Furthermore, the results of animal tests demonstrated that local injection of CMCS/n (miR-21) promoted the early healing of osteoporotic bone defects. +other 32694946 hsa-mir-506 Cholangiocarcinoma Rescue assays verified that linc00473 modulated the tumorigenesis of CCA by regulating miR-506. +genetics_knock down_promote 32694945 hsa-mir-495 Prostatic Neoplasms 3p overexpression on the proliferation, apoptosis, migration, and invasion of PCa cells. +other 32694944 hsa-mir-449b Colorectal Neoplasms In addition, miR-449b-5p could interact with LINC00667 in CRC cells. CONCLUSIONS: LINC00667 is transcriptionally activated by YY1 and promotes cell proliferation and migration in CRC by sponging miR-449b-5p to upregulate YY1. +genetics_overexpression_promote 32694942 hsa-mir-601 Breast Neoplasms Meanwhile, ZEB1 was a target of miR-601, and its overexpression could invert the suppression effect of miR-601 overexpression on the progression of BC. +other 32694937 hsa-mir-182 Cholangiocarcinoma MME-AS1 and hsa-miR-182 were associated with overall survival in ICC patients. +lncRNA target 32694917 hsa-mir-224 Carcinoma, Non-Small-Cell Lung CONCLUSION: Lnc-HCG11 could inhibit the progression of NSCLC by modulating the miR +lncRNA target 32694556 hsa-mir-203 Pulmonary Fibrosis Collectively, circTADA2A repressed lung-fibroblasts activation via miR-526b/Cav1 and reduced lung-fibroblasts proliferation via miR-203/Cav2, thus inhibiting the excessive deposition of ECM and relieving IPF. +lncRNA target 32694556 hsa-mir-526b Pulmonary Fibrosis Collectively, circTADA2A repressed lung-fibroblasts activation via miR-526b/Cav1 and reduced lung-fibroblasts proliferation via miR-203/Cav2, thus inhibiting the excessive deposition of ECM and relieving IPF. +other 32693649 hsa-mir-29b Temporomandibular Joint Disorders The results of the present study indicate that miR-29b is a key regulator of the pro-osteoclastic effects of BMSCs in TMJ-OA subchondral bones and plays important roles in the TMJ-OA progression. +lncRNA target 32693640 hsa-mir-183 Neuroblastoma 5p/FOXP1 axis via suppression of the ERK/AKT pathway. +circulation_biomarker_diagnosis_ns 32693639 hsa-mir-421 Osteosarcoma Furthermore, circCNST was colocalized with miR-421 in the cytoplasm and acted as a sponge of miR-421, which attenuated circCNST-induced proliferation-promoting effects in OS cells by targeting SLC25A3. In conclusion, our findings demonstrate that circCNST promotes the tumorigenesis of OS cells by sponging miR-421, and provides a potential biomarker for patients with OS. +genetics_overexpression_promote 32692910 hsa-mir-25 Hemochromatosis In addition, the overexpression of BTG2 significantly inhibited the proliferation and autophagy abilities of HHL-5 cells, while cotransfected miR +other 32692745 hsa-mir-202 Diabetic Retinopathy aqueous: for DMII-NPDR was miR3p; for DMII-PDR was miR-296, and for DMI-PDR it was miR-3202). +other 32692745 hsa-mir-296 Diabetic Retinopathy aqueous: for DMII-NPDR was miR3p; for DMII-PDR was miR-296, and for DMI-PDR it was miR-3202). +lncRNA target 32692721 hsa-mir-129 Nasopharyngeal Neoplasms In conclusion, NEAT1 increases in NPC tissues and manages to facilitate SAHA tolerance by modulating the miR-129/Bcl-2 axis, providing novel therapeutic targets for NPC treatment. +other 32692718 hsa-mir-1271 Carcinoma, Hepatocellular These findings demonstrate that AC092171.4 promotes growth and progression of HCC by sponging miR-1271 and upregulating GRB2. +genetics_overexpression_suppress 32692577 hsa-mir-124 Pulmonary edema of mountaineers We observed a significant overexpression of miR +lncRNA target 32691705 hsa-mir-22 lung squamous cell carcinoma Lung squamous cell carcinoma cell line SK-MES-1 was selected and the targeting relationship between miR-22 and VEGFR3 was analyzed by double luciferase reporter gene assay. +lncRNA target 32691684 hsa-mir-499 Carcinoma, Hepatocellular Our study identified miR-499 as a tumor-suppressive miR in hepatocellular carcinoma, thus providing a candidate therapeutic target for the future diagnosis or treatment of hepatocellular carcinoma. +circulation_biomarker_diagnosis_up 32691564 hsa-let-7a Pancreatic Carcinoma The level of serum miRNA let-7a may provide a reference for the diagnosis and postoperative monitoring of pancreatic cancer. +lncRNA target 32691413 hsa-mir-27a Diabetic Nephropathies Thus, in this study, the role of miR-27a-3p-prohibitin/TMBIM6 signaling axis in the progression of DN was elucidated. Taken together, we reveal that miR-27a-3p-prohibitin/TMBIM6 signaling axis regulates the progression of DN, which can be a potential therapeutic target. +lncRNA target 32691413 hsa-mir-27a Fibrosis, Renal Thus, in this study, the role of miR-27a-3p-prohibitin/TMBIM6 signaling axis in the progression of DN was elucidated. Taken together, we reveal that miR-27a-3p-prohibitin/TMBIM6 signaling axis regulates the progression of DN, which can be a potential therapeutic target. +other 32690634 hsa-mir-147 Chlamydia Infections In the CTSS group, miR-142 and -147 showed 2.2- to 6.9-fold increases in expression. +other 32690634 hsa-mir-142 Chlamydia Infections In the CTSS group, miR-142 and -147 showed 2.2- to 6.9-fold increases in expression. +lncRNA target 32690611 hsa-mir-23b Breast Neoplasms Together, our data demonstrate that ZBTB1 is a tumor suppressor in breast cancer cells and that targeting the miR-23b-3p/ZBTB1 may serve as a potential therapeutic approach for the treatment of tamoxifen resistant breast cancer. +lncRNA target 32690597 hsa-mir-204 Squamous Cell Carcinoma of Head and Neck MCM3AP-AS1 could also upregulate the expression of FOXC1 via repressing miR +lncRNA target 32690086 hsa-mir-382 Ovarian Neoplasms 5p, increased the expression level of PRPF8, and prompted proliferation and inhibited apoptosis in ovarian cancer cells. +circulation_biomarker_diagnosis_ns 32689754 hsa-mir-24 Pancreatitis Objective: To investigate the significance of microRNA (miR)-216a, miR5p, miR-29a expression in peripheral blood in patients with acute pancreatitis (AP) and their correlation with liver injury. +circulation_biomarker_diagnosis_up 32689754 hsa-mir-29a Pancreatitis The levels of miR-216a and miR-29a in the peripheral blood in the liver injury group were higher than those in the non-liver injury group, and they were higher inSAP patients than those in MAP patients in the liver injury group (all P<0.05). +circulation_biomarker_diagnosis_ns 32689754 hsa-mir-24 Liver Injury Objective: To investigate the significance of microRNA (miR)-216a, miR5p, miR-29a expression in peripheral blood in patients with acute pancreatitis (AP) and their correlation with liver injury. +circulation_biomarker_diagnosis_up 32689754 hsa-mir-29a Liver Injury The levels of miR-216a and miR-29a in the peripheral blood in the liver injury group were higher than those in the non-liver injury group, and they were higher inSAP patients than those in MAP patients in the liver injury group (all P<0.05). +circulation_biomarker_diagnosis_up 32689754 hsa-mir-216a Liver Injury The levels of miR-216a and miR-29a in the peripheral blood in the liver injury group were higher than those in the non-liver injury group, and they were higher inSAP patients than those in MAP patients in the liver injury group (all P<0.05). +circulation_biomarker_diagnosis_up 32689754 hsa-mir-216a Pancreatitis The levels of miR-216a and miR-29a in the peripheral blood in the liver injury group were higher than those in the non-liver injury group, and they were higher inSAP patients than those in MAP patients in the liver injury group (all P<0.05). +genetics_overexpression_suppress 32689640 hsa-mir-134 Heart Diseases 5p or overexpression of Creb1 may show promise as a novel therapeutic strategy to attenuate cardiac dysfunction following AMI. +genetics_overexpression_promote 32689640 hsa-mir-134 Myocardial Infarction 5p or overexpression of Creb1 may show promise as a novel therapeutic strategy to attenuate cardiac dysfunction following AMI. +lncRNA target 32688371 hsa-mir-24 Mucocutaneous Lymph Node Syndrome CONCLUSIONS: SOCS2-AS1 upregulates CUEDC2 via inhibiting miR +lncRNA target 32687483 hsa-mir-6884 Carcinoma, Hepatocellular 3p/CCNB1 axis, suggesting that RP11-295G20.2 may be a potential target for HCC therapy. +lncRNA target 32687454 hsa-mir-223 Carcinoma, Non-Small-Cell Lung In conclusion, SLCO4A1-AS1 drove NSCLC progression by activating NF-kappaB signaling pathway via sponging miR3p to enhance IKKalpha expression. +lncRNA target 32687247 hsa-mir-204 Parkinson Disease 5p sponge and avoided the injury induced by MPP(+) in neuroblastoma cells via targeting miR +lncRNA target 32687246 hsa-mir-143 Melanoma As a result, the present study showed that miR-143 was involved in metastatic and apoptotic pathways, suggesting that miR-143 acts as a tumor-suppressor microRNA in melanoma cancer. +other 32687224 hsa-mir-191 Multiple System Atrophy MicroRNA-7641 and microRNA-191 consistently differentiated between MSA and PD. +other 32687224 hsa-mir-191 late onset Parkinson's disease MicroRNA-7641 and microRNA-191 consistently differentiated between MSA and PD. +other 32687224 hsa-mir-7641 Multiple System Atrophy MicroRNA-7641 and microRNA-191 consistently differentiated between MSA and PD. +other 32687224 hsa-mir-7641 late onset Parkinson's disease MicroRNA-7641 and microRNA-191 consistently differentiated between MSA and PD. +genetics_GWAS 32686997 hsa-mir-196a-2 Pre-Eclampsia The maternal or placental miRNA-196a2 rs11614913 and miRNA-499 rs3746444 polymorphisms were unrelated to the severity of preeclampsia. +lncRNA target 32686982 hsa-mir-199b Triple Negative Breast Neoplasms And DLX6-AS1 function through miR-199b-5p/PXN in TNBC cells. In brief, DLX6-AS1 promoted cell proliferation, EMT, and cisplatin resistance through miR-199b-5p/PXN signaling in TNBC in vitro and in vivo. +other 32686039 hsa-mir-122 Tuberculosis Graphical abstract A sensitive surface-enhanced Raman scattering (SERS) biosensor was developed to detect microRNA 122 using the configuration change of DNA tetrahedron to indirectly control the position of TB and hot spot. +lncRNA target 32685991 hsa-mir-374a Glioma These results suggest that miR-374a is a new candidate target for glioma therapy, whereas E-CHP fusion protein has the potential to be developed as a multifunctional carrier for targeted drug delivery and therapy. +genetics_knock down_promote 32685551 hsa-mir-7 Thyroid Cancer, Papillary ciRS-7 silencing could attenuate effects on PTC cells induced by miR-7 knockdown. +lncRNA target 32685535 hsa-mir-133 Myocardial Reperfusion Injury OBJECTIVE: This project is aimed at investigating whether CircANXA2 can promote the apoptosis of myocardial cells by inhibiting miR-133 expression and thereby participate in the development of myocardial ischemia-reperfusion injury. CONCLUSIONS: CircANXA2 promotes cardiomyocyte apoptosis in myocardial ischemia-reperfusion injury by inhibiting the expression of miR-133. +genetics_knock down_promote 32685526 hsa-mir-198 Thyroid Neoplasms In addition, in the TC cell lines, the knockdown of circITGA7 or overexpression of miR-198 significantly suppressed FGFR1 levels. +genetics_overexpression_promote 32685496 hsa-mir-7 Colorectal Neoplasms Overexpression of miR +lncRNA target 32685419 hsa-mir-135b Infertility Suppressing HOXA-10 Gene Expression by MicroRNA 135b During the Window of Implantation in Infertile Women. +other 32685390 hsa-mir-509 Uveal melanoma Otherwise, three miRNAs, hsa-miR3-5p, hsa-miR-513a-5p, and hsa-miR-1269a were associated with UVM prognosis. +other 32685390 hsa-mir-513a Uveal melanoma Otherwise, three miRNAs, hsa-miR3-5p, hsa-miR-513a-5p, and hsa-miR-1269a were associated with UVM prognosis. +other 32685390 hsa-mir-1269a Uveal melanoma Otherwise, three miRNAs, hsa-miR3-5p, hsa-miR-513a-5p, and hsa-miR-1269a were associated with UVM prognosis. +other 32685001 hsa-mir-181a Ossification of Posterior Longitudinal Ligament Conclusions: Our data unveiled the mechanism by which the miR-181a-5p/PBX1 axis functions in the development of OPLL, and it revealed the therapeutic effects of the miR-181a-5p antagomir in preventing OPLL development both in vivo and in vitro. +other 32684859 hsa-mir-15a Glioblastoma AIM: To evaluate the effect of radiotherapy and temozolomide on the expression of miRNAs apoptotic (miRNAs-21, -221, -222 (anti-apoptotic) and miRNAs-15a, -16 (pro-apoptotic)) and the gene MGMT in glioblastoma cell lines. +other 32684859 hsa-mir-21 Glioblastoma AIM: To evaluate the effect of radiotherapy and temozolomide on the expression of miRNAs apoptotic (miRNAs-21, -221, -222 (anti-apoptotic) and miRNAs-15a, -16 (pro-apoptotic)) and the gene MGMT in glioblastoma cell lines. +other 32684859 hsa-mir-221 Glioblastoma AIM: To evaluate the effect of radiotherapy and temozolomide on the expression of miRNAs apoptotic (miRNAs-21, -221, -222 (anti-apoptotic) and miRNAs-15a, -16 (pro-apoptotic)) and the gene MGMT in glioblastoma cell lines. +other 32684844 hsa-mir-876 Prostatic Neoplasms MCM3AP-AS1/miR-876-5p/WNT5A axis regulates the proliferation of prostate cancer cells. +lncRNA target 32684842 hsa-mir-936 Osteosarcoma CONCLUSIONS: Circ_0005909 inhibition impeded the progression of OS via downregulating HMGB1 via sponging miR-936. +other 32684738 hsa-mir-363 Esophageal Squamous Cell Carcinoma Therefore, ESCC patients with miRNA-363 expression < 7 had a worse prognosis than patients expressing miRNA-363 7, P = 0.049. +circulation_biomarker_diagnosis_ns 32684596 hsa-mir-182 Coronary Artery Disease 5p in CAD was significantly lower than that in normal population, while the content of serum PAPPA was significantly increased, and the expression level of miR +lncRNA target 32684096 hsa-mir-200a Glioma INC00467 promoted the development of glioma by inhibiting miR-200a and promoting E2F3 expression. +circRNA target 32683852 hsa-mir-337 Glioma 3p that was a tumor suppressor in glioma and circFANCL targeted miR +lncRNA target 32683841 hsa-mir-10a Pancreatic Carcinoma miR-10a-5p can promote the occurrence and development of pancreatic cancer by regulating the BDNF / SEMA4C pathway, and may become a molecular target for the diagnosis and treatment of pancreatic cancer in the future. +lncRNA target 32683798 hsa-mir-17 Inflammation In-depth studies of the mechanisms of action of miR-17 were performed in primary RA fibroblast-like synoviocytes (FLS) isolated from synovial tissue. +lncRNA target 32683798 hsa-mir-17 Arthritis, Rheumatoid In-depth studies of the mechanisms of action of miR-17 were performed in primary RA fibroblast-like synoviocytes (FLS) isolated from synovial tissue. +transcription factor target 32683666 hsa-mir-708 Glaucoma 3p contributed to the apoptosis of RGCs through promoting autophagy in glaucoma. +transcription factor target 32683666 hsa-mir-335 Glaucoma 3p contributed to the apoptosis of RGCs through promoting autophagy in glaucoma. +lncRNA target 32683589 hsa-mir-1270 Carcinoma, Hepatocellular CONCLUSION: Hsa-circRNA-103809 promoted development of HCC via sequestering miR-1270 and up-regulating PLAGL2. +epigenetics 32683553 hsa-mir-217 Ischemic Stroke In addition, DNA methylation-mediated silencing of miR +other 32683553 hsa-mir-217 Brain Ischemia Evidence has been shown that miR5p is significantly downregulated in infarcted brain areas following focal cerebral ischemia. +transcription factor target 32683553 hsa-mir-217 Ischemia Our data indicated that miR5p could attenuate ischemic injury by inhibiting PTEN. +exosome 32683448 hsa-mir-100 Coronary Artery Disease 5p in exosomes are increased upon senescence and exhibit a trend to correlate with the severity of coronary artery disease. +exosome 32683448 hsa-mir-21 Coronary Artery Disease 5p in exosomes are increased upon senescence and exhibit a trend to correlate with the severity of coronary artery disease. +lncRNA target 32683077 hsa-mir-200a Prostatic Neoplasms When miR-200a/b was evaluated according to clinicopathological parameters, it acted as an onco-miR in local/local advanced PCa and as a tumor-suppressor-miR in metastatic stage. +lncRNA target 32683077 hsa-mir-200b Prostatic Neoplasms When miR-200a/b was evaluated according to clinicopathological parameters, it acted as an onco-miR in local/local advanced PCa and as a tumor-suppressor-miR in metastatic stage. +circRNA target 32683074 hsa-mir-143 Diabetic Nephropathies In conclusion, we demonstrated the regulatory role of circ_0000064 in DN and clarified that circ_0000064 play a role in DN via targeting miR-143. +genetics_overexpression_suppress 32682951 hsa-mir-206 Osteosarcoma In this research, we found that overexpression of transformer 2beta (TRA2B) was associated with tumor progression in osteosarcoma, and TRA2B was the target gene of miR-206, which was downregulated in osteosarcoma tissues. +other 32682786 hsa-mir-122 Hypertension Previous studies revealed that microRNA-122 (miR-122) levels were elevated in the aortic adventitia of hypertensive rats with vascular injury. +other 32682786 hsa-mir-122 Vascular System Injuries Previous studies revealed that microRNA-122 (miR-122) levels were elevated in the aortic adventitia of hypertensive rats with vascular injury. +transcription factor target 32682786 hsa-mir-122 Wounds and Injuries MiR5p may be a novel predictive biomarker of adventitial injury, and targeting the SIRT6-ELA-ACE2 signaling may have the potential therapeutic importance of controlling vascular remodeling and disorders. +genetics_knock down_promote 32682784 hsa-mir-1 Colorectal Neoplasms Silencing LATS2 reversed the inhibition effects of overexpression of LINC00689 or knockdown of miR +lncRNA target 32682570 hsa-mir-4268 Aortic Valve Stenosis CONCLUSIONS: MicroRNA3p and microRNA-4268 have potential new roles in the modulation of the hypertrophic response to AS via the renin-angiotensin-aldosterone system and as predictors of reverse remodeling after aortic valve replacement. +lncRNA target 32682570 hsa-mir-101 Aortic Valve Stenosis CONCLUSIONS: MicroRNA3p and microRNA-4268 have potential new roles in the modulation of the hypertrophic response to AS via the renin-angiotensin-aldosterone system and as predictors of reverse remodeling after aortic valve replacement. +other 32682279 hsa-mir-654 familial temporal lobe epilepsy 3 In terms of predicting the surgical prognosis of MTLE-HS patients, miR3p proved to be the only microRNA evaluated to present statistical power to differentiate, as a peripheral biomarker, Engel I from Engel III-IV patients. +other 32682279 hsa-mir-654 Tuberous Sclerosis In terms of predicting the surgical prognosis of MTLE-HS patients, miR3p proved to be the only microRNA evaluated to present statistical power to differentiate, as a peripheral biomarker, Engel I from Engel III-IV patients. +genetics_overexpression_promote 32682121 hsa-mir-129 Acute Lung Injury Overexpression of miR +genetics_overexpression_promote 32682121 hsa-mir-129 Sepsis Overexpression of miR +transcription factor target 32682111 hsa-mir-483 Arthritis, Rheumatoid 3p was upregulated in RA, which markedly promoted cell proliferation, induced the G0/G1-to-S phase transition, and suppressed apoptosis in RA FLSs, whereas miR +genetics_knock down_promote 32682012 hsa-mir-664b Carcinoma, Hepatocellular In addition, GSKIP overexpression markedly reversed OTUD6B-AS1 knockdown- or miR-664b-3p overexpression-induced antitumour effects in HCC. +other 32681863 hsa-mir-1 Cardiomegaly This ex-vivo model revealed that miR1 and miR133a play a key role in activating early processes leading to myocardium hypertrophy and epicardium hyperplasia and confirmed the expected similarities with hypertrophic disease that occurs in humans. +other 32681863 hsa-mir-133a Cardiomegaly This ex-vivo model revealed that miR1 and miR133a play a key role in activating early processes leading to myocardium hypertrophy and epicardium hyperplasia and confirmed the expected similarities with hypertrophic disease that occurs in humans. +lncRNA target 32681842 hsa-mir-221 Cataract, Age-Related 3p/PI3K/AKT pathway, indicating a new insight into the pathogenesis of ARC and providing a potential therapeutic target for ARC. +lncRNA target 32681833 hsa-mir-432 Carcinoma, Non-Small-Cell Lung In this work, through screening of 2019 mature microRNAs, multiple microRNAs were identified that drive EGFR-inhibitor resistance in non-small cell lung cancer cell lines, including miR5p. +lncRNA target 32681722 hsa-mir-1 Colorectal Neoplasms Together, our study suggests that re-expressing TINCR may suppress invasive outgrowth of CRC through miR-31. +lncRNA target 32681706 hsa-mir-525 Ovarian Neoplasms In summary, MAGI2-AS3 repressed the progression of OV by targeting miR5p/MXD1 axis, offering a novel insight into understanding OV at the molecular level. +genetics_overexpression_promote 32681617 hsa-mir-124 Nasopharyngeal Carcinoma Overexpression of miR-124 inhibited stemness properties and enhanced radiosensitivity of NPC cells in vitro and in vivo via targeting JAMA. +genetics_knock down_promote 32681581 hsa-mir-1184 Colorectal Neoplasms The knockdown of AJUBA, a downstream target of miR-1184, reversed the effect of miR-1184 in CRC cells via enhancing the phosphorylation of the Hippo/YAP signalling pathway proteins MST1, LATS1 and YAP. +circulation_biomarker_diagnosis_up 32681443 hsa-mir-214 Alzheimer Disease 3p was downregulated in the plasma of AD patients and SK-N-SH and SK-N-AS cells treated with Abeta and isoflurane. +other 32681442 hsa-mir-222 Diabetes Mellitus The effects of high glucose on human PL cells death were studied, as well as the expression of microRNA-221 and microRNA-222, potentially modulated by DM. +other 32681442 hsa-mir-221 Diabetes Mellitus The effects of high glucose on human PL cells death were studied, as well as the expression of microRNA-221 and microRNA-222, potentially modulated by DM. +other 32681092 hsa-mir-185 Colorectal Neoplasms In brief, our findings uncovered that circAGFG1 modulated YY1/CTNNB1 axis to drive metastasis and stemness in CRC by sponging miR-4262 and miR5p. +other 32681092 hsa-mir-4262 Colorectal Neoplasms In brief, our findings uncovered that circAGFG1 modulated YY1/CTNNB1 axis to drive metastasis and stemness in CRC by sponging miR-4262 and miR5p. +other 32680978 hsa-mir-338 Diabetes Mellitus In conclusion, these findings reveal the promotion of circVEGFC/miR3p/HIF-1alpha/VEGFA axis in the HG-induced ECs' apoptosis, providing a potential treatment strategy for ECs' damage in DM. +genetics_overexpression_promote 32680921 hsa-mir-155 Glioma Overexpression of miR-155 and the miR-23a cluster promoted tumorigenesis in U87 glioma cells. +lncRNA target 32679539 hsa-mir-29b Myocardial Reperfusion Injury CONCLUSION: DEX could ameliorate MIR injury (MIRI) and H/R injury in rats and inhibit H/R induced pyroptosis in myocardial cells via down-regulating miR-29b to activate FoxO3a/ARC axis. +other 32679234 hsa-mir-93 Acute Kidney Injury 5p in sepsis-induced AKI, which was mediated by regulation KDM6BH/3K27me3/TNF-alpha axis. +other 32679234 hsa-mir-93 Sepsis 5p in sepsis-induced AKI, which was mediated by regulation KDM6BH/3K27me3/TNF-alpha axis. +genetics_knock down_promote 32679145 hsa-mir-27a Spinal Cord Injuries HDAC3 knockdown by its specific shRNA restored the locomotor function of SCI rats and prevented rat neurons from H(2)O(2)-induced apoptosis through promotion of miR-27a. +transcription factor target 32679144 hsa-mir-182 Non-alcoholic Fatty Liver Disease SIGNIFICANCE We presented a possible mechanism that oxymatrine alleviated hepatic lipid metabolism via regulating miR-182 in NAFLD model. +lncRNA target 32679142 hsa-mir-423 Osteoarthritis 5p-mediated KDM5C in OA, which may provide potential therapeutic target for OA. +other 32678870 hsa-mir-361 Stomach Neoplasms In summary, ABHD11-AS1 boosts GC development by regulating miR3p/PDPK1 signalling. +transcription factor target 32678819 hsa-mir-451 Myocardial Reperfusion Injury So this study revealed that upregulation of miR-451 could prevent myocardial I/R injury by suppressing HMGB1. +genetics_overexpression_suppress 32678693 hsa-mir-203a Carcinoma, Non-Small-Cell Lung Functionally, we found overexpression of miR-203a-3p inhibited cell proliferation, migration and invasion in NSCLC cells by targeting AVL9. +genetics_knock down_suppress 32678674 hsa-mir-497 Stomach Neoplasms Conclusion: The present work suggested that circ_0081143 knockdown ameliorated hypoxia-induced migration, invasion, and EMT in GC cells at least partly by the miR +lncRNA target 32678617 hsa-mir-515 Carcinoma, Hepatocellular suppressing onco-miR-515 enhanced the expression of anti-oncogenes (P21, CD22, TIMP1, NFKB, and E-cadherin) in cancer cells. +circulation_biomarker_prognosis_down 32678466 hsa-mir-149 Colorectal Neoplasms In conclusion, combined serum miR-29c and miR-149 expression analysis established novel noninvasive biomarker for early CRC diagnosis. +circulation_biomarker_prognosis_down 32678466 hsa-mir-29c Colorectal Neoplasms In conclusion, combined serum miR-29c and miR-149 expression analysis established novel noninvasive biomarker for early CRC diagnosis. +other 32678165 hsa-mir-512 Contrast Induced Nephropathy The findings of this study demonstrated that deregulation of lncRNA-HULC/miR-512/PTGS1/PGE1 might be involved in the pathogenesis of CIN. +genetics_knock down_promote 32678071 hsa-mir-1343 Pancreatic Carcinoma Gain- and loss-of-function assays and mechanistic assays were applied to verify the effects of LINC01559, miR +genetics_overexpression_suppress 32678069 hsa-mir-15a Arthritis, Rheumatoid Overexpression SOX5 in RA-FLSs decreases miR-15a/16 expression and rescues miR-15a/16-mediated inhibitory effect. +genetics_overexpression_suppress 32678069 hsa-mir-16 Arthritis, Rheumatoid Overexpression SOX5 in RA-FLSs decreases miR-15a/16 expression and rescues miR-15a/16-mediated inhibitory effect. +genetics_knock down_suppress 32678044 hsa-mir-138 Hypertension, Pulmonary 5p is predicted to regulate the expression of the potassium channel KCNK3, whose loss is associated with the development and progression of PAH. +other 32677984 hsa-mir-497 Urinary Bladder Neoplasms The CASC9/miR5p/ FZD6 axis provides insights for regulatory mechanism of bladder cancer, and new strategies for clinical practice. +genetics_overexpression_promote 32677950 hsa-mir-136 Glioma Overexpression of miR +lncRNA target 32677473 hsa-mir-383 Diabetic Nephropathies In particular, LINC00162 and HDAC9 were highly expressed, while miR-383 was lowly expressed in tissues derived from the T2D DN group compared with those in tissues derived from the T2D - DN group. In summary, we suggested for the first time that down-regulation of LINC00162 was associated with the development of DN in T2D via the up-regulation of miR-383 expression and reduction of HDAC9 expression. +genetics_overexpression_suppress 32677423 hsa-mir-495 Arthritis, Rheumatoid Overexpression of miR-495 could inhibit RA-FLS proliferation and inflammatory factors of interleukin (IL)-6, IL-11 and tumor necrosis factor alpha (TNF-alpha), and decrease the protein expression of MMP-9 and MMP-2. +circulation_biomarker_diagnosis_ns 32677394 hsa-mir-146a Sepsis METHODS: The expressions of lncRNA MALAT1 and miR-146a in U937 cells and peripheral blood samples of the rats with and without LPS-induced sepsis were detected using quantitative real-time reverse transcription PCR (qRT-PCR). CONCLUSIONS: LncRNA MALAT1 modulates the immunoreaction of rats with LPS -induced sepsis by targeting miR-146a/NF-kappaB P65. +circulation_biomarker_diagnosis_up 32677047 hsa-mir-133a Hypertrophy, Left Ventricular Then, circulating miR-133a levels in plasma from 40 MHD patients and 20 healthy controls are analyzed by such assay. +genetics_GWAS 32676506 hsa-mir-27b Colorectal Neoplasms 5p) downregulated in KRAS mutated condition. +genetics_GWAS 32676506 hsa-let-7d Colorectal Neoplasms 5p) downregulated in KRAS mutated condition. +genetics_GWAS 32676506 hsa-mir-149 Colorectal Neoplasms 5p) downregulated in KRAS mutated condition. +genetics_GWAS 32676506 hsa-mir-191 Colorectal Neoplasms 5p) downregulated in KRAS mutated condition. +genetics_GWAS 32676506 hsa-mir-10a Colorectal Neoplasms 5p) downregulated in KRAS mutated condition. +genetics_GWAS 32676506 hsa-mir-15b Colorectal Neoplasms 5p) downregulated in KRAS mutated condition. +transcription factor target 32676415 hsa-mir-210 Carcinoma, Renal Cell 5p levels were elevated in advanced disease (with added diagnostic accuracy via addition of miR +circulation_biomarker_diagnosis_ns 32676367 hsa-mir-1 ST Elevation Myocardial Infarction CONCLUSIONS: Circulating miR-1 at admission is an independent predictor of LV remodeling 6 months after STEMI. +other 32675943 hsa-mir-155 Stomach Neoplasms The MRTF-A/miR-155/SOX1 pathway mediates gastric cancer migration and invasion. +other 32675746 hsa-mir-485 Carcinoma, Hepatocellular 5p to up-regulate MUC1. +genetics_overexpression_promote 32675397 hsa-mir-196a Osteosarcoma RESULTS: MiR-196a was overexpressed and HOXA5 was low expressed in osteosarcoma versus the non-tumor tissues and normal cell lines. +genetics_knock down_promote 32675392 hsa-mir-410 Breast Neoplasms Knockdown of miR +transcription factor target 32675391 hsa-mir-140 Stomach Neoplasms 5p, providing a potential therapeutic target for GC. +lncRNA target 32675387 hsa-mir-153 Mouth Neoplasms CONCLUSIONS: Our research revealed lncRNA FGD5-AS1 acted as an oncogene by regulating MCL1 via sponging miR +genetics_overexpression_promote 32675386 hsa-mir-21 Ovarian Neoplasms Recovery of miR-21 expression in circ9119-overexpressing OC cells showed that miR-21 exhibited the opposite effect on circ9119; moreover, its recovery could suppress the effects of circ9119 overexpression, recover cell proliferation, and reduce apoptosis. +circulation_biomarker_diagnosis_ns 32674689 hsa-mir-92b Osteoporosis RESULTS: We observed increased levels of serum estrogen in both ovaries, elevated miR-92b-3p levels in bone tissues, reduced levels of Nox4, NF-kappaBp65, p-IkappaB-a, and cathepsin K, and elevated gene and protein expression of BMP2, Smad7, and RUNX-2 in the OVX rat model of osteoporosis after treatment with RES. +other 32674274 hsa-mir-374b Lung Neoplasms high miR-374a/b expression was associated with poor patient survival rates. In lung cancer cells, the EMT signal induced miR-374a/b expression, which, in turn, promoted EMT and invasiveness. +other 32674274 hsa-mir-374a Lung Neoplasms high miR-374a/b expression was associated with poor patient survival rates. In lung cancer cells, the EMT signal induced miR-374a/b expression, which, in turn, promoted EMT and invasiveness. +genetics_overexpression_promote 32674073 hsa-mir-107 Enterovirus B, Human Overexpressions of KLF4 and BACE1 negatively regulated CVB3 replication, this effect on CVB3 was completely opposite to that of miR-107. +circRNA target 32673817 hsa-mir-140 Arthritis, Rheumatoid In conclusion, this study revealed that circ0088036 may play an essential role in promoting synovial pathogenesis via the circ0088036/miR +circulation_biomarker_diagnosis_ns 32673627 hsa-mir-106a Glomerulonephritis, Membranoproliferative RESULTS: These results showed that miR-106a-5p and miR-30a-5p were highly expressed in MsPGN patients compared with healthy controls and could discriminate MsPGN from healthy controls with an area under the ROC curve (AUC) of 0.93. CONCLUSION: Plasma miR-30a-5p and miR-106a-5p can serve as novel and potential diagnostic biomarkers for MsPGN. +lncRNA target 32673066 hsa-mir-490 Carcinoma, Hepatocellular Conclusion: circ_0091579 promoted cell proliferation, migration, invasion, and glycolysis partially through miR +lncRNA target 32673063 hsa-mir-4430 Esophageal Neoplasms Here, lncRNA RP11-159D12.2 might function as a ceRNA in regulating BIRC5 expression of esophagus cancer through competitively binding to hsa-miR-4430. Conclusions: PLK1, BIRC5, hsa-miR-4430, and lncRNA RP11-159D12.2 were likely to be associated with esophageal cancer development. +exosome 32672418 hsa-mir-27a Breast Neoplasms Ectopic expression and inhibition of miR-27a-3p in breast cancer cells were achieved by transduction with mimics and inhibitors. Conjointly, exosomal miR-27a-3p promotes immune evasion by up-regulating PD-L1 via MAGI2/PTEN/PI3K axis in breast cancer. +other 32672363 hsa-mir-1249 Fatty Liver In conclusion, we characterize the vital role of miR5p in negatively regulating MCP-1 expression in vitro and in vivo, which may open new perspectives for pharmacological treatment of liver disease. +circulation_biomarker_diagnosis_up 32672342 hsa-mir-24 Cerebral Infarction CONCLUSION miR-24 reduced serum TCH, HDL and TG levels and inhibited brain tissue cell apoptosis in rats with cerebral infarction. +exosome 32671583 hsa-mir-940 Colorectal Neoplasms CONCLUSION: MSC-exosomal miR +other 32671202 hsa-mir-27a Stomach Neoplasms Furthermore, GCLET increased FOXP2 expression by competing with miR-27a-3p, and this regulation remarkably affected in vitro, in vivo, and clinical gastric cancer phenotypes. +other 32671067 hsa-mir-223 Neurodegenerative Diseases Despite miR-223 upregulation in numerous neurodegenerative conditions, largely in cells of the myeloid lineage, the role of miR-223 in the retina is relatively unexplored. +transcription factor target 32671067 hsa-mir-223 Retinal Diseases Further investigations are required to determine the targets of miR-223 and their key biological pathways and interactions that are relevant to retinal diseases. +lncRNA target 32671067 hsa-mir-223 Inflammation MicroRNA3p (miR-223) is known to be a critical regulator of the innate immune response, and its dysregulation is thought to play a role in inflammatory disease progression. +lncRNA target 32671065 hsa-mir-188 Osteoporosis In conclusion, our research indicates that hsa_circ_0026827 promotes osteoblast differentiation of DPSCs via Beclin1 and the RUNX1 signaling pathways by sponging miR3p, which suggests novel therapeutics for osteoporosis treatment. +target gene 32670881 hsa-mir-199a Carcinoma, Hepatocellular Hypoxia-Induced lncRNA-NEAT1 Sustains the Growth of Hepatocellular Carcinoma via Regulation of miR-199a-3p/UCK2. +genetics_overexpression_promote 32670392 hsa-mir-215 Colorectal Neoplasms In addition, the result of rescue experiments showed that overexpression of SCD could promote the proliferation, migration, and invasion of CRC cells, and the carcinogenic effect of SCD could be inhibited by miR-215. +other 32670363 hsa-mir-204 Cardiovascular Diseases After adjustment for potential confounders, miR-204 was independently associated with CVD in patients with T2DM. +other 32670363 hsa-mir-204 Diabetes Mellitus, Type 2 After adjustment for potential confounders, miR-204 was independently associated with CVD in patients with T2DM. +genetics_knock down_promote 32670359 hsa-mir-125a Osteosarcoma Moreover, inhibition of miR-125a-5p abrogated the biological roles of lncRNA MRUL knockdown on OS cell proliferation, migration, and invasion. In conclusion, these results demonstrated that OS-upregulated lncRNA MRUL promoted cell proliferation, and metastasis via negatively regulating miR-125a-5p, and imply that lncRNA MRUL may be a potential biomarker for OS. +other 32670176 hsa-mir-146a Alzheimer Disease This communication will review our current understanding of miRNA-146a, its induction by the NF-kB-stimulating actions of inflammatory mediators, including the secretory products of certain microbial species such as viral vectors, and Gram-negative bacteria (such as Bacteroides fragilis) that are normal residents of the human gastrointestinal (GI) tract microbiome, and how miRNA-146a appears to contribute to neuro-pathological, neuro-inflammatory, and altered neuro-immunological aspects of both Alzheimer's disease (AD) and prion disease (PrD). +other 32670176 hsa-mir-146a Prion Diseases This communication will review our current understanding of miRNA-146a, its induction by the NF-kB-stimulating actions of inflammatory mediators, including the secretory products of certain microbial species such as viral vectors, and Gram-negative bacteria (such as Bacteroides fragilis) that are normal residents of the human gastrointestinal (GI) tract microbiome, and how miRNA-146a appears to contribute to neuro-pathological, neuro-inflammatory, and altered neuro-immunological aspects of both Alzheimer's disease (AD) and prion disease (PrD). +transcription factor target 32670070 hsa-mir-26b Heart Diseases Thus, we conclude that miR-26b-5p/ATF3/JUN are key targets of AS-IV and play an important role in maintaining cardiac homeostasis and regulating cardiac remodeling. +other 32669977 hsa-mir-646 Retinoblastoma METHODS: Real-time PCR (RT-PCR) was used to detect circ_0000527 and miR-646 expression in RB tissues and cells. CONCLUSION: Circ_0000527 enhances the proliferation and metastasis of RB cells by modulating the miR-646/LRP6 axis. +lncRNA target 32669973 hsa-mir-138 Prostatic Neoplasms 5p alleviated the malignant progression of PCa by targeting and downregulating FOXC1. +lncRNA target 32669972 hsa-mir-429 Carcinoma, Pancreatic Ductal CONCLUSION: OIP5-AS1 exerted oncogenic function in PDAC cells through targeting miR-429/FOXD1/ERK pathway. +lncRNA target 32669970 hsa-mir-498 Thyroid Neoplasms CONCLUSIONS: TMPO-AS1 promotes cell proliferation in TC via sponging miR-498 to modulate TMPO. +lncRNA target 32669962 hsa-mir-141 Colorectal Neoplasms 3p inhibitor reversed the anti-proliferation effect of sh-ZEB1-AS1 on colorectal cancer cells. +circRNA target 32669960 hsa-mir-1233 Stomach Neoplasms This study unveils a mechanism by which hsa-circ-0007766 regulates GDF15 via hsa-circ-0007766/miR +other 32669952 hsa-mir-651 Nasopharyngeal Carcinoma Conclusions: Collectively, this study reported for the first time that hsa_circ_0066755 played a role of oncogene in NPC and could be used as an effective diagnostic marker for NPC, and that hsa_circ_0066755 / miR-651 axis also involved in the progression of NPC. +genetics_overexpression_promote 32669877 hsa-mir-4429 Uterine Cervical Neoplasms Moreover, the rescue experiment revealed that the overexpression of FOXM1 reversed the influences of miR-4429 overexpression on the proliferation, migration, invasion, and EMT of CCCs. +target gene 32669876 hsa-mir-4504 Lung Neoplasms LncRNA PSMA3-AS1 Promotes Lung Cancer Growth and Invasion via Sponging MiR-4504. +target gene 32669873 hsa-mir-101 Pancreatic Neoplasms Honokiol Suppressed Pancreatic Cancer Progression via miR-101/Mcl-1 Axis. +lncRNA target 32669871 hsa-mir-628 Glioma 5p targeted MAGT1, and Sev modulated glioma progression via circ_0002755/miR +genetics_knock down_promote 32669857 hsa-mir-150 Colorectal Neoplasms 5p, and its overexpression also could invert the effect of lnc-NEAT1 knockdown on CRC progression. +lncRNA target 32669856 hsa-mir-491 Carcinoma, Non-Small-Cell Lung CONCLUSION: Inhibition of TTN-AS1 hindered cell proliferation, migration, invasion and EMT in NSCLC cells by modulating miR +circulation_biomarker_diagnosis_ns 32669469 hsa-let-7b Weil Disease The study established the role of the circulating stable miRNAs (miR +circulation_biomarker_diagnosis_ns 32669469 hsa-mir-21 Weil Disease The study established the role of the circulating stable miRNAs (miR +circulation_biomarker_diagnosis_ns 32669469 hsa-mir-144 Weil Disease The study established the role of the circulating stable miRNAs (miR +circulation_biomarker_diagnosis_ns 32669422 hsa-mir-150 Leukemia Leukemia specimens from patients exposed to fractionated radiation showed depletion of miR5p in blood. +other 32669295 hsa-mir-122 Carcinoma, Hepatocellular We identify 24 primary microRNAs with significant changes in processing efficiency from normal liver to hepatocellular carcinoma, among those the highly expressed miRNA-122 and miRNA-21, demonstrating that differential processing of primary microRNAs is occurring and could be involved in disease. +other 32669295 hsa-mir-21 Carcinoma, Hepatocellular We identify 24 primary microRNAs with significant changes in processing efficiency from normal liver to hepatocellular carcinoma, among those the highly expressed miRNA-122 and miRNA-21, demonstrating that differential processing of primary microRNAs is occurring and could be involved in disease. +lncRNA target 32669002 hsa-mir-485 Diabetic Nephropathies In short, XIST silencing could alleviate biological process and inflammation of HMCs treated with high glucose by sponging miR-485. +circulation_biomarker_diagnosis_ns 32668808 hsa-mir-106b Astrocytoma Resolved CUSA-EV sncRNAs could discriminate serum-EV sncRNA profiles from GBM and GII-III patients and healthy controls and 14 miRNAs (including miR3p and miR-106b-3p) and cancer-associated piRNAs (piR_016658, _016659, _020829 and _204090) were also significantly expressed in serum-EVs. +circulation_biomarker_diagnosis_ns 32668808 hsa-mir-106b Glioblastoma Resolved CUSA-EV sncRNAs could discriminate serum-EV sncRNA profiles from GBM and GII-III patients and healthy controls and 14 miRNAs (including miR3p and miR-106b-3p) and cancer-associated piRNAs (piR_016658, _016659, _020829 and _204090) were also significantly expressed in serum-EVs. +circulation_biomarker_diagnosis_ns 32668728 hsa-let-7 Hepatitis C The present study, therefore, aimed to investigate whether expression levels for the full spectrum of let-7 family members (let-7a, 7b, 7c, 7d, 7e, 7f, 7g, 7i, and miR-98) in the circulatory system are useful as surveillance biomarkers for liver-related diseases to monitor treatment efficacy during HCV infection. Therefore, considering the circulating levels of let7 b/c/g as representatives of the let-7 family may facilitate effective monitoring of liver-related disease. +other 32668728 hsa-let-7b Hepatitis C Let-7b/c/g represented the three clusters and showed the best survival response to liver cancer when analyzed with respect to patient data. +transcription factor target 32668597 hsa-mir-216b Carcinoma, Non-Small-Cell Lung MiR-216b increases B-cell lymphoma 2 (BCL-2) expression and promotes chemoresistance of NSCLC cells by decreasing apoptosis. Taken together, these results suggest that smoking-mediated upregulation of miR-216b increases NSCLC cell growth by downregulating Smad3 and inhibiting TGF-beta-induced tumor suppressor function, and induces resistance to platinum-based therapy. +genetics_overexpression_promote 32668414 hsa-mir-29a Ovarian Neoplasms Mechanistically, circFGFR3 upregulates E2F1 expression by sponging miR-29a-3p, and the overexpression of E2F1 or the suppression of miR-29a-3p induces OC cell EMT. Therefore, circFGFR3 serves as a promoter of OC by inducing OC cell EMT via the miR-29a-3p/E2F1 axis and circFGFR3 may be a prognostic biomarker for OC patients. +lncRNA target 32668286 hsa-mir-616 Breast Neoplasms Circ_DCAF6 assisted in Hh signal pathway activation via the up-regulation of GLI1 by sponging miR +genetics_knock down_promote 32667865 hsa-let-7d Enterocolitis, Necrotizing Overexpression of let-7d-5p resulted in decreased levels of proinflammatory factors in the intestinal tissues of NEC rats. +other 32667746 hsa-mir-148a Endometriosis Altogether, the results demonstrate that circ_0004712/miR-148a-3p plays an important role in E(2) -induced EMT process in the development of endometriosis, and the molecular mechanism may be associated with the beta-catenin pathway. +lncRNA target 32667692 hsa-mir-548i Carcinoma, Hepatocellular Overall, the circNFATC3 can sponge miR-548I to protect NFATC3 itself, then it regulates hepatoma cell function via the JNK, c-Jun, AKT, and mTOR signaling pathways, and the circNFATC3 can be a tumor-repressor on HCC. +transcription factor target 32667627 hsa-mir-641 Ovarian Neoplasms Targeting ciRS-7/miR-641/ZEB1 or ciRS-7/miR-641/MDM2 axis may be a novel diagnostic, prognostic and therapeutic strategy for OC. +genetics_overexpression_promote 32667078 hsa-mir-21 Ataxia Neuropathy Spectrum overexpression BMDCs could alleviate renal IR-induced pro-inflammatory cytokines production and acute kidney injury (AKI). +genetics_overexpression_promote 32666494 hsa-mir-223 Endotoxemia 3p expression partially reversed the cytotoxicity and pyroptosis of HK-2 cells upon LPS stimulation or with DLX6-AS1 overexpression. +genetics_overexpression_promote 32666494 hsa-mir-223 Acute Kidney Injury 3p expression partially reversed the cytotoxicity and pyroptosis of HK-2 cells upon LPS stimulation or with DLX6-AS1 overexpression. +other 32666288 hsa-mir-21 Diabetic Nephropathies The current study indicates that geraniol interfered with miRNA-21/ PTEN/AKT/mTORC1 pathway signaling that contributes largely to the progression of mesangial expansion and extracellular matrix deposition in diabetic nephropathy. +genetics_overexpression_promote 32665904 hsa-mir-30 Colorectal Neoplasms 5p expressions according to the COAD and READ projects showed that BACH1 was overexpressed, but miR +other 32665773 hsa-mir-33a Carcinoma, Hepatocellular One of the miRNA/gene pair, hsa-miR-33a/ALDH1A3 was significantly associated with the survival rate of LIHC patients. +lncRNA target 32665670 hsa-mir-1180 Carcinoma, Hepatocellular Dysregulated miR +lncRNA target 32665564 hsa-mir-9 Airway Inflammation In summary, our study elucidates the pro-inflammatory roles of the lncRNA RP11-86H7.1-miR5p-NFKB1 regulatory network in airway inflammation induced by TRAPM2.5 and indicates that the components of this network might serve as novel diagnostic biomarkers and potential therapeutic targets. +exosome 32664984 hsa-mir-124 Brain Injuries CONCLUSIONS: CX3CL1/CX3CR1 axis may be a potential intervention target for the inhibition of SAH-induced EBI by promoting exosome transport of miR-124 to microglia. +exosome 32664984 hsa-mir-124 Subarachnoid Hemorrhage CONCLUSIONS: CX3CL1/CX3CR1 axis may be a potential intervention target for the inhibition of SAH-induced EBI by promoting exosome transport of miR-124 to microglia. +lncRNA target 32664763 hsa-mir-218a Pancreatitis After 24 h of acute severe pancreatitis induced by taurocholate, emodin reduced the expression of miR-218a-5p in the intestinal tract; increased the expression of Notch1 and Bcl-2; decreased the expression levels of RhoA, ROCK1, Akt, Bax, Fas, FasL, caspase-3, and caspase-9; inhibited the intestinal cell apoptosis caused by acute severe pancreatitis; increased the protein expression levels of occludin, zonula occludens-1 (ZO-1), and E-cadherin in the intestinal tract; and alleviated intestinal dysfunction caused by acute severe pancreatitis. +genetics_GWAS 32664737 hsa-mir-214 Radiation Injuries Our results confirmed that the downregulation of ataxia telangiectasia mutated (ATM) was regulated by miR3p, which was enriched in MSC-EVs. +lncRNA target 32664488 hsa-mir-122 Neuralgia An early GCSF treatment can suppress MCP-1 expressions, through upregulating microRNA-122 expressions in the DRGs of CCI rats at an earlier stage, thus indirectly attenuating neuropathic pain development. +other 32664305 hsa-mir-298 Diabetes Mellitus 3p, and miR-298 can be introduced as a diagnostic tool for the prediction of T2DM (area under the curve (AUC) = 94.0%, 88.0%, and 84.0%, respectively). +other 32664305 hsa-mir-1307 Prediabetic State 3p, and miR-298 can be introduced as a diagnostic tool for the prediction of T2DM (area under the curve (AUC) = 94.0%, 88.0%, and 84.0%, respectively). +other 32664305 hsa-mir-298 Prediabetic State 3p, and miR-298 can be introduced as a diagnostic tool for the prediction of T2DM (area under the curve (AUC) = 94.0%, 88.0%, and 84.0%, respectively). +other 32664305 hsa-mir-1307 Diabetes Mellitus 3p, and miR-298 can be introduced as a diagnostic tool for the prediction of T2DM (area under the curve (AUC) = 94.0%, 88.0%, and 84.0%, respectively). +other 32664305 hsa-mir-491 Prediabetic State 3p, and miR-298 can be introduced as a diagnostic tool for the prediction of T2DM (area under the curve (AUC) = 94.0%, 88.0%, and 84.0%, respectively). +other 32664305 hsa-mir-491 Diabetes Mellitus 3p, and miR-298 can be introduced as a diagnostic tool for the prediction of T2DM (area under the curve (AUC) = 94.0%, 88.0%, and 84.0%, respectively). +lncRNA target 32663980 hsa-mir-9 Depressive Disorder, Major Mechanism research has demonstrated that circDYM, acting as a microRNA-9 sponge, suppressed microglial activation by increasing Heat Shock Protein 90 ubiquitination, indicating that circDYM could be a potential biomarker of MDD. +other 32663836 hsa-mir-126 Diabetes, Gestational In the placenta, for miR3p, there was a differential effect of DM by birth weight between DM versus control group, expression being lower at the lower birth weight, however not different at the higher birth weight. +other 32663314 hsa-mir-19b Heart Failure But in view of satisfactory accuracy of NT-proBNP in predicting HF from the healthy volunteers, miR-19b did not provide incremental value. +lncRNA target 32663252 hsa-mir-214 Carcinoma, Hepatocellular Therefore, those results suggested HCG18 functioned as an oncogene to promote the proliferation and migration of HCC cells via miR +lncRNA target 32662411 hsa-mir-146a Arthritis, Rheumatoid CONCLUSIONS: Iguratimod ameliorates RA progression via regulating miR-146a mediated IRAK1 expression and TRAF6/JNK1 pathway. +lncRNA target 32661617 hsa-mir-194 Fibrosis, Renal MiR-194 mimics significantly reduced pathological damage and alleviated renal fibrosis that caused by UOO, and inhibited the expression levels of alpha-SMA and collagen I. +lncRNA target 32661474 hsa-mir-499a Carcinoma, Pancreatic Ductal We found that miR-499a was significantly up-regulated in PDAC tissues compared with adjacent tissues, and protein-protein interaction (PPI) and gene ontology (GO) analyses indicated programmed cell death protein 4 (PDCD4) is a key target gene of miR-499a, which is involved in the regulation of transcription, cellular biosynthetic process, RNA metabolic process, and other multiple biologic processes. In conclusion, we first found miR-499a was significantly up-regulated in PDAC tissues, and we promoted PANC-1 cell proliferation by down-regulating PDCD4 expression. +lncRNA target 32661236 hsa-mir-21 Uterine Cervical Neoplasms Mechanistically, GAS5 was transcriptionally modulated by P-STAT3 and served as a competing endogenous RNA (ceRNA) of miR-21 to indirectly affect cisplatin sensitivity through PDCD4 regulation in CC cells. GAS5 was regulated by P-STAT3 and affected the sensitivity of CC to cisplatin-based chemotherapy through the miR-21/PDCD4 axis. +other 32660984 hsa-mir-140 Growth Disorders 3p to the phenotype remains to be determined. +other 32660984 hsa-mir-140 Osteoarthritis 3p to the phenotype remains to be determined. +transcription factor target 32660795 hsa-mir-203a Diabetes Mellitus RESULTS: miR-203a-3p was found to be located in the RPE layer of the retinas from normal and diabetic rats and SOCS3 was a direct target of miR-203a-3p. +other 32660795 hsa-mir-203a Duane Retraction Syndrome Deregulation of miR-203a-3p/SOCS3/JNK/c-Jun cascade thus may serve as an important contributor to RPEs apoptosis in DR. +lncRNA target 32660602 hsa-mir-204 Pulmonary Arterial Hypertension CONCLUSION: PA and QS improved PAH possibly by affecting the expression of PARP1 and miR-204 and their downstream targets, HIF1a and NFATc2. +lncRNA target 32660514 hsa-mir-502 Ovarian Neoplasms CONCLUSIONS: MIR502, which is regulated by NRF1, acts as a tumour suppressor gene to accelerate apoptosis and suppress proliferation by targeting the Hippo signalling pathway in ovarian cancer. +lncRNA target 32660466 hsa-mir-29a Pancreatic Carcinoma The findings suggest an anti-tumorigenic role of miR-29a in the context of PSC-cancer cell crosstalk and advocates for the potential of the molecule in PDAC targeted therapies. +circulation_biomarker_diagnosis_up 32660465 hsa-mir-137 Osteoporosis RESULTS: FTX was suppressed in OP samples and serums, however, miR-137 was greatly elevated. +lncRNA target 32660221 hsa-mir-34a Breast Neoplasms This study aimed at evaluating the potential effects of miR-34a alone or in combination with paclitaxel on breast cancer cells. METHODS: After miR-34a transduction by lentiviral vectors in two MCF-7 and MDA-MB-231 cell lines of breast cancer, effects of the elevated expression of miR-34a in the cell viability and the cell proliferation were determined using MTT assay in treated and untreated cells with paclitaxel. +epigenetics 32660176 hsa-mir-1180 Carcinoma, Hepatocellular 3p relevant ceRNA regulatory network, and DNA methylation-mediated F11-AS1 and F11-AS1/miR +other 32659676 hsa-mir-221 Neoplasm Metastasis These validated methods are reliable and are currently in use to support a first-in-human clinical trial of LNA-i-miR-221 in patients affected by refractory multiple myeloma and advanced solid tumors. +other 32659676 hsa-mir-221 Refractive Errors These validated methods are reliable and are currently in use to support a first-in-human clinical trial of LNA-i-miR-221 in patients affected by refractory multiple myeloma and advanced solid tumors. +other 32659676 hsa-mir-221 Multiple Myeloma These validated methods are reliable and are currently in use to support a first-in-human clinical trial of LNA-i-miR-221 in patients affected by refractory multiple myeloma and advanced solid tumors. +exosome 32659442 hsa-mir-221 Plaque, Atherosclerotic Here, we test the hypothesis that microRNA-221 (miR-221) from MSC-derived extracellular vesicles (EVs) alleviates AS. +lncRNA target 32659427 hsa-mir-34a Pancreatic Carcinoma In patients with pancreatic cancer, the expression levels of DNMT1 were negatively related with those of miR-34a. Therefore, the results of our study suggest that downregulation of DNMT enhances the expression of miR-34a and may be a potential therapeutic target for pancreatic cancer. +other 32659284 hsa-mir-203a Liver Cirrhosis Notably, the increased p66Shc and Mical2 levels and decreased miR-203a-3p levels in murine fibrosis were consistent with those in patients with liver fibrosis. In sum, our study reveals that p66Shc is critical for liver fibrosis and that Mical2, miR-203a-3p and p66Shc compose a novel regulatory pathway in liver fibrosis. +transcription factor target 32659265 hsa-mir-629 Laryngeal Neoplasms Moreover, MYCT1 inhibited the EMT and migration of laryngeal cancer cells through the SP1/miR +circulation_biomarker_diagnosis_up 32659236 hsa-mir-149 Esophageal Squamous Cell Carcinoma 5p inhibitors and negative control groups, NFIB high expression plasmid, NFIB low expression plasmid and empty vector were transfected into EC cells (Eca-109 and EC9706) to detect changes in cell biological behavior and autophagy protein expression. +transcription factor target 32659049 hsa-mir-16 Hypertension, Pulmonary In conclusion, DHA inhibits the proliferation and migration of PASMCs, and probably ameliorates PAH via regulating miR-16/CaSR axis. +genetics_overexpression_promote 32658600 hsa-mir-137 Carcinoma, Non-Small-Cell Lung In addition, knock-down of circ-LDLRAD3 and miR-137 overexpression promoted NSCLC cell apoptosis, and inhibited cell proliferation and invasion. +circulation_biomarker_diagnosis_ns 32658439 hsa-mir-488 Ischemic Stroke CONCLUSIONS: In summary, the high expression of miR-488 in the peripheral blood of patients with acute ischemic stroke is closely related to the severity of the disease. +lncRNA target 32658431 hsa-mir-9 Glioma BACKGROUND: Mir-9 was recognized as a potential tumor suppressor gene or oncogene in varies of diseases; however, its roles in glioma have not been investigated. +circulation_biomarker_prognosis_ns 32658408 hsa-mir-424 Melanoma Moreover, results of ROC analysis showed both tissue and serum expression of miR-424 can serve as diagnostic biomarker for melanoma. +lncRNA target 32658123 hsa-mir-132 Parkinson Disease 5p inhibition might exert a protective role in MPTP-treated PD models by targeting ULK1, indicating that miR +lncRNA target 32658033 hsa-mir-34a Colorectal Neoplasms Clinical miR-34a mimic or inhibitor targeting LOXL3 might have a potential protective role when patients with CRC anesthetized by desflurane. +other 32657574 hsa-mir-182 Colorectal Neoplasms With this method, simultaneous detection of three colorectal cancer-related microRNA (miRNA), including miRNA-21, miRNA-17, and miRNA-182, could be easily achieved with femtomolar sensitivity by using a commercial flow cytometer. +other 32657574 hsa-mir-21 Colorectal Neoplasms With this method, simultaneous detection of three colorectal cancer-related microRNA (miRNA), including miRNA-21, miRNA-17, and miRNA-182, could be easily achieved with femtomolar sensitivity by using a commercial flow cytometer. +other 32657574 hsa-mir-17 Colorectal Neoplasms With this method, simultaneous detection of three colorectal cancer-related microRNA (miRNA), including miRNA-21, miRNA-17, and miRNA-182, could be easily achieved with femtomolar sensitivity by using a commercial flow cytometer. +transcription factor target 32657216 hsa-mir-296 Rectal Neoplasms These consequences indicated that GRINA, which might be regulated by miR-296, acted stimulative important impact on rectal cancer cells, insinuating that GRINA might be a novel potential target for rectal cancer therapy. +transcription factor target 32657157 hsa-mir-34a AIDS-Associated Nephropathy Together, our data provide a new mechanism of SIRT1 regulation and its downstream effects in HIVinfected kidney cells and indicate that SIRT1/miR-34a are potential drug targets to treat HIV-related kidney disease. +circRNA target 32657138 hsa-mir-29 Leukemia, Myeloid, Acute Results:hsa_circ_0001947 functions as a tumor inhibitor to suppress AML cell proliferation through hsa-miR5p/CREBRF axis. +lncRNA target 32656992 hsa-mir-101 Neuralgia Taken together, miR-101 could potentially promote hypersensitivity and inflammatory response of microglial cells and aggravate neuropathic pain in CCI rat models by inhibiting MKP-1 in the MAPK signalling pathway. +genetics_knock down_promote 32656268 hsa-mir-223 Esophageal Squamous Cell Carcinoma Mannose receptor (MR) knockdown significantly upregulated miR +lncRNA target 32656212 hsa-mir-18a Bowen-Conradi syndrome CONCLUSION: CBSCs reduce fibroblast to myofibroblast transition and differentiation in adult cardiac fibroblasts via miR-18a-5p. +genetics_overexpression_promote 32656089 hsa-mir-622 Pancreatic Carcinoma overexpressing EVs could transfer miR-622, which significantly elevated miR-622 expression and decreased cell invasion and migration via inhibition of the EMT pathway in recipient PDAC cells. +other 32656071 hsa-mir-1826 Stomach Neoplasms Results: Three miRNAs were found to be associated with survival of LAGC (P < 0.001 for miR-132, P = 0.011 for miR-548a-3p, and P < 0.001 for miR-1826). +other 32656071 hsa-mir-548a Stomach Neoplasms Results: Three miRNAs were found to be associated with survival of LAGC (P < 0.001 for miR-132, P = 0.011 for miR-548a-3p, and P < 0.001 for miR-1826). +other 32655835 hsa-mir-133b Fibromatosis, Aggressive The miR-133b-SIRT1-beta-catenin axis may represent a novel mechanism underlying progression of FAP-associated DT. +target gene 32655834 hsa-mir-708 Lung Neoplasms miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells. +genetics_overexpression_suppress 32655821 hsa-mir-1294 Squamous Cell Carcinoma of Head and Neck miR-1294 overexpression repressed LSCC cell proliferation and aggressiveness. +other 32655815 hsa-mir-370 Ovarian Neoplasms The expression of PVT1 positively regulated malignant behaviors in ovarian cancer cells, including cell proliferation, migration and invasion, which could be reversed by the introduction of miR-370 mimics. +genetics_overexpression_promote 32655809 hsa-mir-195 Carcinoma, Renal Cell We observed that miR-195 overexpression inhibits the abilities of RCC cell proliferation, cell cycle progression and metastasis in vitro by targeting HMGA1 via epithelial to mesenchymal transition (EMT) pathway. +lncRNA target 32655807 hsa-mir-101a Reperfusion Injury CONCLUSIONS: Our findings revealed miR-101a may be a therapeutic target for the therapeutic target for ischemic heart diseases and expanded our understanding of the molecular mechanism underling the progression of I/R injury. +lncRNA target 32655807 hsa-mir-101a Myocardial Ischemia CONCLUSIONS: Our findings revealed miR-101a may be a therapeutic target for the therapeutic target for ischemic heart diseases and expanded our understanding of the molecular mechanism underling the progression of I/R injury. +lncRNA target 32655805 hsa-mir-205 Ischemic Stroke Altogether, these results suggest that MALAT1 may suppress the apoptosis in ischemic stroke and function as a ceRNA for miR3p to modulate PTEN expression. +other 32655792 hsa-mir-1204 Breast Neoplasms CircMMP11 acts as a ce-circRNA in breast cancer progression by regulating miR-1204. +genetics_knock down_promote 32655790 hsa-mir-101 Colorectal Neoplasms Knockdown of circAPLP2 and overexpression of miR +lncRNA target 32655789 hsa-mir-129 Carcinoma, Non-Small-Cell Lung Thus, LINC01619 promotes NSCLC development via regulating PAX6 by suppressing miR +target gene 32655783 hsa-mir-485 Leukemia, Myeloid, Acute LncRNA LINC00265/miR-485-5p/IRF2-mediated autophagy suppresses apoptosis in acute myeloid leukemia cells. +circulation_biomarker_diagnosis_up 32655673 C19MC cluster Obesity, Maternal CONCLUSIONS: C19MC miRNA expression upregulation in the fetal circulation during the gestation of overweight/obese pregnant women may contribute to altered multisystem metabolic pathway development in their offspring. +other 32655560 hsa-let-7 Mycosis Fungoides Let-7 was decreased at PND 35 while miR-199a and miR-199b were increased at PND 51 in MF compared to HM. +other 32655560 hsa-mir-199a Mycosis Fungoides Let-7 was decreased at PND 35 while miR-199a and miR-199b were increased at PND 51 in MF compared to HM. +other 32655560 hsa-mir-181 Mycosis Fungoides miR-148 and miR-181 were decreased in MF compared to HM at PND 21. +other 32655560 hsa-mir-148 Mycosis Fungoides miR-148 and miR-181 were decreased in MF compared to HM at PND 21. +other 32655560 hsa-mir-199b Mycosis Fungoides Let-7 was decreased at PND 35 while miR-199a and miR-199b were increased at PND 51 in MF compared to HM. +other 32655542 hsa-mir-200a Plaque, Atherosclerotic Our study demonstrates that miR-200a has anti-inflammatory and anti-atherosclerotic activities dependent on the EZH2/STAT3 signaling cascade. +other 32655542 hsa-mir-200a Inflammation Our study demonstrates that miR-200a has anti-inflammatory and anti-atherosclerotic activities dependent on the EZH2/STAT3 signaling cascade. +lncRNA target 32655407 hsa-mir-687 Acute Kidney Injury Mechanistically, a luciferase reporter assay and additional research showed that lncRNA 6406 functioned as a ceRNA to sponge miRNA-687, thereby modulating LPS-stimulated AKI by targeting the miR-687/PTEN axis; thus, this study presents a novel therapeutic strategy or sepsis-associated AKI. +circulation_biomarker_diagnosis_ns 32655365 hsa-mir-150 Amyloidosis, Hereditary, Transthyretin-Related Further investigations are needed on the role of circulating miR +genetics_overexpression_promote 32655321 hsa-mir-641 Carcinoma, Non-Small-Cell Lung Consistently, overexpression of circRNA CDR1as increased drug resistance of DDP-sensitive NSCLC cells by regulating miR-641/HOXA9 axis. +circRNA target 32655319 hsa-mir-873 Uterine Cervical Neoplasms 5p-TUSC3 function network involved in the CC progression, which provides mechanistic insights into the roles of CircRNAs in CC progression and a promising therapeutic target for CC treatment. +exosome 32655298 hsa-mir-1298 Carcinoma, Hepatocellular CONCLUSION: The exosomal hsa-miRNA-1298, lncRNA-RP11-583F2.2 can be potential biomarkers for HCC diagnosis. +genetics_overexpression_promote 32655137 hsa-mir-451 Adenocarcinoma of Lung Functional studies indicated that SNHG15 and multidrug resistance protein 1 (MDR-1) were overexpressed and possess tumor-promoting functions in gefitinib-resistant LUAD cells while miR-451 was downregulated and possess tumor-suppressive behaviors in gefitinib-resistant LUAD cells. +circulation_biomarker_diagnosis_ns 32654912 hsa-mir-185a Alzheimer Disease CONCLUSIONS miR-185a-5p in serum is a candidate as a non-invasive ACR biomarker (area under the curve=0.80 and negative predicted value=98%). +genetics_overexpression_promote 32654912 hsa-mir-181a Alzheimer Disease In the validation phase, miR-181a-5p relative expression (2-Cq) in the ACR group (n=45) was significantly overexpressed (p < 0.0001) vs the no-ACR group (n=45). +circulation_biomarker_diagnosis_ns 32654473 hsa-mir-34a Diabetes Mellitus, Type 1 We aimed, for the first time, to assess the expression of exosomal micro-RNA 34a (miR-34a) in serum of children and adolescents with T1DM and correlate this expression with markers of dyslipidemia and endothelial dysfunction. +circulation_biomarker_diagnosis_ns 32654473 hsa-mir-34a Cardiovascular Diseases We aimed, for the first time, to assess the expression of exosomal micro-RNA 34a (miR-34a) in serum of children and adolescents with T1DM and correlate this expression with markers of dyslipidemia and endothelial dysfunction. +other 32654289 hsa-mir-145 Esophageal Squamous Cell Carcinoma Based on TCGA database analysis and Reverse transcription quantitative polymerase chain reaction determination, high expression of LINC00337 and FSCN1 was detected, while miR-145 exhibited a low expression in EC. +lncRNA target 32654025 hsa-mir-1288 Colorectal Neoplasms Taken together, the current study demonstrated FGF14-AS2 as a regulator of colorectal cancer development via downregulation of miR +transcription factor target 32653922 hsa-mir-29b Liver Cirrhosis In comparison with patients without liver fibrosis, miR-29b-3p level was remarkably reduced in those with liver fibrosis. Our study demonstrates that low expression of miR-29b-3p may contribute to the progression of liver fibrosis by suppressing STAT3. +other 32653739 hsa-mir-146b Anovulation Here, we report that miR-146b, a conserved and ovary-enriched miRNA, modulates estradiol (E2) secretion, GC apoptosis, and follicular atresia in pigs. Genome-wide analysis and quantitative real-time PCR revealed that miR-146b was significantly upregulated during follicular atresia, and fluorescence-activated cell sorting showed that miR-146b functioned as a proapoptotic factor to induce GC apoptosis. +lncRNA target 32653692 hsa-let-7g Aortic Aneurysm, Thoracic CONCLUSIONS: HIF1A-AS1 regulated the proliferation, apoptosis ,and the activity of extracellular matrix proteins in VSMCs through modulating APAF1 by targeting let-7g, leading to the development of TAA. +transcription factor target 32653643 hsa-mir-370 Colitis NFATc3 mediated the inhibitory effects of miR +transcription factor target 32653643 hsa-mir-370 Colorectal Neoplasms NFATc3 mediated the inhibitory effects of miR +genetics_overexpression_promote 32653032 hsa-mir-140 Esophageal Squamous Cell Carcinoma 3p-induced inhibitory effects on ESCC cell malignant phenotypes were attenuated by the overexpression of circNTRK2. +other 32652747 hsa-mir-142 Bone Diseases Abnormal expression and involvement of microRNA-142 (miR-142) have been identified in many diseases, including bone-related diseases. +other 32652647 hsa-let-7 Ovarian Neoplasms, High-Grade Serous Surprisingly, in these HGSOC cells, stemness could be dissociated from invasiveness: Cells with lower let-7 levels were more tumorigenic, but less migratory, and with a lower EMT score, than those with higher let-7 levels. We conclude that let-7 expression and epithelial/mesenchymal state are valuable predictors of HGSOC proliferation, in vitro self-renewal, and tumor burden in vivo. +circRNA target 32652519 hsa-mir-33a Breast Neoplasms These findings showed that circEIF3M promotes triple-negative breast cancer progression via the circEIF3M/ miR-33a/ cyclin D1 axis. +transcription factor target 32652502 hsa-mir-93 Influenza, Human Here we found influenza A virus (IAV) infection significantly inhibited miR-93 expression in alveolar epithelial type II cells through RIG-I/JNK pathway. +genetics_GWAS 32652066 hsa-mir-214 Brain Injuries CONCLUSIONS: Exosomes from MSCs conduct powerful neuroprotection against cerebral injury induced by DHCA, which can be further enhanced by genetic modification of the exosomes to overexpress miR-214. +genetics_GWAS 32652066 hsa-mir-214 Dermatitis Herpetiformis CONCLUSIONS: Exosomes from MSCs conduct powerful neuroprotection against cerebral injury induced by DHCA, which can be further enhanced by genetic modification of the exosomes to overexpress miR-214. +other 32651991 hsa-mir-1294 Polycystic Ovary Syndrome And a circLDLR-miRCYP19A1 competing endogenous RNA (ceRNA) network was predicted by cytoscape software, and confirmed by luciferase assay and correlative expression in the cumulus cells of PCOS patients. +other 32651898 hsa-let-7i Endometriosis The diagnostic value of the 14 downregulated miRNAs in ovarian endometriosis was evaluated by receiver operating characteristic (ROC) curve analysis, and hsa-let-7i-5p showed the highest area under the ROC curve (AUC) with a value of 0.900. +circulation_biomarker_diagnosis_ns 32651705 hsa-mir-196a Osteoporosis, Postmenopausal LncRNA LOXL1-AS1 controls osteogenic and adipocytic differentiation of bone marrow mesenchymal stem cells in postmenopausal osteoporosis through regulating the miR-196a-5p/Hmga2 axis. MATERIALS AND METHODS We examined the expression levels of LOXL1-AS1, miR-196a-5p and Hmga2 in peripheral blood from postmenopausal osteoporosis patients by RT-qPCR, and detected their changes during the osteogenic differentiation of hBMMSCs by RT-qPCR. +transcription factor target 32650835 hsa-mir-183 psoriasis 1 3p exhibited inhibition property in the proliferation and migration of HaCaT cells via down-regulation of GAB1, suggesting the potential therapeutic strategy for psoriasis. +other 32650806 hsa-mir-920 Osteoporosis METHODS Osteoporosis (OP) and healthy control bone tissues were collected, and the relative expression of miR-920 and HOXA7 was measured. +other 32650806 hsa-mir-920 Osteoporosis-pseudoglioma syndrome METHODS Osteoporosis (OP) and healthy control bone tissues were collected, and the relative expression of miR-920 and HOXA7 was measured. RESULTS We found that miR-920 was downregulated in OP patients compared with controls, while HOXA7 was upregulated, and miR-920 had a negative correlation with HOXA7 (r = - 0.859, P = 0.001). +genetics_overexpression_promote 32650766 hsa-mir-663 Urinary Bladder Neoplasms In BC cells, downregulated TGF-beta1 and upregulated miR-663 were observed after the overexpression of PLAC2. +genetics_knock down_promote 32650755 hsa-mir-1908 Breast Neoplasms 3p promoted the cells proliferation, migration and invasion while knockdown of miR +genetics_knock down_promote 32650615 hsa-mir-122 Liver Cirrhosis Alternatively, we compared the published datasets of human cirrhotic livers and miR-122 KO livers, which revealed upregulation of BCL2, suggesting its potential role in regulating fibrosis. +genetics_knock down_suppress 32650237 hsa-mir-34a Aortic Aneurysm, Abdominal In a rescue experiment, miR-34a knockdown or forced expression of SIRT1 partially attenuated the protective effects of METTL3 deficiency against AAA formation. +lncRNA target 32649737 hsa-mir-125b Colorectal Neoplasms In addition, restoring the level of miR-125b-5p by transfection with the mimic sequence not only significantly blocked the production of lactate and intracellular fatty acids but also suppressed the migration and invasion of chemoresistant colon cancer cells. +genetics_knock down_promote 32649368 hsa-mir-107 Carcinoma, Non-Small-Cell Lung Lung epithelial BEAS-2B cells were transfected with MEG8 overexpression plasmid, and NSCLC A549 and H1299 cells were transfected with MEG8 or miR-107 overexpression/knockdown plasmid to detect the function of MEG8 or miR-107 on cell activity. +circulation_biomarker_diagnosis_up 32649312 hsa-mir-29 Alzheimer Disease We aimed to examine whether miRNA-29s (miR-29s) in serum are associated with cognitive impairment in Parkinson's disease (PD). +circulation_biomarker_diagnosis_up 32649312 hsa-mir-29 Parkinson Disease We aimed to examine whether miRNA-29s (miR-29s) in serum are associated with cognitive impairment in Parkinson's disease (PD). +genetics_GWAS 32648858 hsa-mir-486 Arthritis, Rheumatoid 5p with relevance for rheumatoid arthritis and cancer related mutations BRAF and KRAS of ctDNA were directly measured. +genetics_GWAS 32648858 hsa-mir-223 Arthritis, Rheumatoid 5p with relevance for rheumatoid arthritis and cancer related mutations BRAF and KRAS of ctDNA were directly measured. +genetics_overexpression_promote 32648768 hsa-mir-448 Pituitary Neoplasms Overexpression of miR-448 significantly inhibited the proliferation and migration of pituitary adenoma cells. +other 32648688 hsa-mir-26a Adenocarcinoma of Lung CONCLUSIONS: CEACAM6 promotes DDP resistance in LUAD by affecting the epithelial-mesenchymal transition (EMT) phenotype and stemness, which is post-transcriptionally regulated by miR-146a and miR-26a. +other 32648688 hsa-mir-146a Adenocarcinoma of Lung CONCLUSIONS: CEACAM6 promotes DDP resistance in LUAD by affecting the epithelial-mesenchymal transition (EMT) phenotype and stemness, which is post-transcriptionally regulated by miR-146a and miR-26a. +genetics_overexpression_promote 32648622 hsa-let-7b Epilepsy, Temporal Lobe Overexpression of let-7b inhibited hippocampal glial cell activation, inflammatory response and epileptic seizures by targeting Stat3. CONCLUSIONS: LncRNA H19 could competitively bind to let-7b to promote hippocampal glial cell activation and epileptic seizures by targeting Stat3 in a rat model of temporal lobe epilepsy. +genetics_overexpression_promote 32648622 hsa-let-7b Epilepsy Overexpression of let-7b inhibited hippocampal glial cell activation, inflammatory response and epileptic seizures by targeting Stat3. CONCLUSIONS: LncRNA H19 could competitively bind to let-7b to promote hippocampal glial cell activation and epileptic seizures by targeting Stat3 in a rat model of temporal lobe epilepsy. +lncRNA target 32648571 hsa-mir-127 Carcinoma, Hepatocellular Down-regulation of hsa_circ_0026134 suppressed TRIM25- and IGF2BP3-mediated HCC cell proliferation and invasion via promotion of miR +transcription factor target 32648361 hsa-mir-145 Cardiomyopathies Previously, our lab demonstrated that miR-145 acts to suppress cardiac fibrosis through inhibition of the TGF-beta signaling pathway. +lncRNA target 32648233 hsa-mir-34a Nasopharyngeal Carcinoma CONCLUSIONS: Our results demonstrate that miR-34a/AXL can inhibit NPC cell migration, invasion and EMT through inhibition of AKT/Snail signaling. +lncRNA target 32648125 hsa-mir-221 Vascular Diseases 3p in the microvascular dysfunction in diabetic retinopathy by targeting TIMP3, representing a potential therapeutic target for human diabetic retinopathy. +lncRNA target 32648125 hsa-mir-221 Diabetic Retinopathy 3p in the microvascular dysfunction in diabetic retinopathy by targeting TIMP3, representing a potential therapeutic target for human diabetic retinopathy. +genetics_overexpression_promote 32648079 hsa-mir-503 Liver Cirrhosis In CCl(4)-induced hepatic fibrosis model in rats, miR-503 overexpression aggravated, whereas SMAD7 overexpression improved CCl(4)-induced fibrotic changes in rats' liver tissues. +circulation_biomarker_diagnosis_up 32647955 hsa-mir-27a Pancreatitis The levels of miR-27a-5p, tumor necrosis factor (TNF) receptor-associated factor 3 (Traf3) in serum of AP patient, or cerulein-treated AR42J cells were detected by qRT-PCR. +circulation_biomarker_diagnosis_up 32647955 hsa-mir-27a Inflammation The levels of miR-27a-5p, tumor necrosis factor (TNF) receptor-associated factor 3 (Traf3) in serum of AP patient, or cerulein-treated AR42J cells were detected by qRT-PCR. +circulation_biomarker_diagnosis_ns 32647681 hsa-mir-143 Instent Restenosis CONCLUSIONS: A lower plasma level of mir-143/145 predicts a higher risk of ISR and a worse outcome. +circulation_biomarker_diagnosis_ns 32647681 hsa-mir-145 Instent Restenosis CONCLUSIONS: A lower plasma level of mir-143/145 predicts a higher risk of ISR and a worse outcome. +genetics_overexpression_suppress 32647679 hsa-mir-28 Liver Neoplasms miR-328-3p overexpression attenuates the malignant proliferation and invasion of liver cancer via targeting Endoplasmic Reticulum Metallo Protease 1 to inhibit AKT phosphorylation. +lncRNA target 32647500 hsa-mir-377 Myocardial Infarction Nevertheless, there were rarely reports about the impact of miR-377 on myocardial ischemia injury. CONCLUSIONS: In short, our findings suggested that miR-377/LILRB2 might regard as a hopeful therapeutic target for myocardial ischemic. +transcription factor target 32647415 hsa-mir-133a Leukemia, Myeloid, Acute It has been finally confirmed that miR-133a-5p could strongly suppress TIM-3 expression in AML cell line. +other 32647409 hsa-mir-181b-1 Breast Neoplasms Thus, we suggested hsa-mir-181b-1 and CYLD might be involved in the pathogenesis of breast cancer and could be considered as two biomarkers for prediction, prognosis and diagnosis of the stages of the breast cancer. +lncRNA target 32647147 hsa-mir-143 Stomach Neoplasms 3p/MAP3K7 axis in GC progression, providing inspiration for further understanding of the mechanism of GC and making CCDC144NL-AS1 as a potential novel diagnostic and therapeutic target for GC. +other 32647133 hsa-mir-370 Heart Failure 3p and restores HCN4 mRNA and protein and I(f) in the sinus node and blunts the sinus bradycardia. +other 32646740 hsa-let-7d Neurotic Disorders Recent studies have shown that Lethal-7 (let-7) microRNA (miRNA) is involved in a wide range of psychiatric disorders such as anxiety, depression, schizophrenia, and cocaine addiction. +other 32646740 hsa-let-7d Schizophrenia Recent studies have shown that Lethal-7 (let-7) microRNA (miRNA) is involved in a wide range of psychiatric disorders such as anxiety, depression, schizophrenia, and cocaine addiction. +lncRNA target 32646740 hsa-let-7d Alcoholism Taken together, the data indicating that let-7d impaired ethanol-related behaviors by targeting D3R will open up new exciting possibilities and might provide potential therapeutic evidence for alcoholism. +other 32646740 hsa-let-7d Cocaine-Related Disorders Recent studies have shown that Lethal-7 (let-7) microRNA (miRNA) is involved in a wide range of psychiatric disorders such as anxiety, depression, schizophrenia, and cocaine addiction. +other 32646740 hsa-let-7d Anxiety Disorders Recent studies have shown that Lethal-7 (let-7) microRNA (miRNA) is involved in a wide range of psychiatric disorders such as anxiety, depression, schizophrenia, and cocaine addiction. +other 32646740 hsa-let-7d Mental Disorders Recent studies have shown that Lethal-7 (let-7) microRNA (miRNA) is involved in a wide range of psychiatric disorders such as anxiety, depression, schizophrenia, and cocaine addiction. +other 32646740 hsa-let-7 Cocaine-Related Disorders Recent studies have shown that Lethal-7 (let-7) microRNA (miRNA) is involved in a wide range of psychiatric disorders such as anxiety, depression, schizophrenia, and cocaine addiction. +other 32646740 hsa-let-7 Mental Disorders Recent studies have shown that Lethal-7 (let-7) microRNA (miRNA) is involved in a wide range of psychiatric disorders such as anxiety, depression, schizophrenia, and cocaine addiction. +other 32646740 hsa-let-7 Anxiety Disorders Recent studies have shown that Lethal-7 (let-7) microRNA (miRNA) is involved in a wide range of psychiatric disorders such as anxiety, depression, schizophrenia, and cocaine addiction. +other 32646740 hsa-let-7 Neurotic Disorders Recent studies have shown that Lethal-7 (let-7) microRNA (miRNA) is involved in a wide range of psychiatric disorders such as anxiety, depression, schizophrenia, and cocaine addiction. +lncRNA target 32646740 hsa-let-7 Alcoholism Taken together, the data indicating that let-7d impaired ethanol-related behaviors by targeting D3R will open up new exciting possibilities and might provide potential therapeutic evidence for alcoholism. +other 32646740 hsa-let-7 Schizophrenia Recent studies have shown that Lethal-7 (let-7) microRNA (miRNA) is involved in a wide range of psychiatric disorders such as anxiety, depression, schizophrenia, and cocaine addiction. +other 32646202 hsa-mir-29b Hearing Loss 3p in the deaf group. +circulation_biomarker_prognosis_ns 32645898 hsa-mir-195 Breast Neoplasms This study demonstrates the prognostic ability of miR-21, miR-195 and miR-145 as circulating biomarkers stratifying breast cancer patients by NACT response, identifying patients that will derive the maximum benefit from chemotherapy. +circulation_biomarker_prognosis_ns 32645898 hsa-mir-145 Breast Neoplasms This study demonstrates the prognostic ability of miR-21, miR-195 and miR-145 as circulating biomarkers stratifying breast cancer patients by NACT response, identifying patients that will derive the maximum benefit from chemotherapy. +other 32645898 hsa-mir-21 Breast Neoplasms Luminal cancer NACT responders were found to have significantly decreased levels of miR-145 (p = 0.033) and miR-21 (p = 0.048), compared to non-responders. +genetics_overexpression_promote 32645691 hsa-mir-1271 Prostatic Neoplasms Mechanistically, circMBOAT2 overexpression upregulated the expression of mTOR by acting as a decoy for miR +other 32645689 hsa-mir-138 Carcinoma, Hepatocellular While, we verified miR-138 as an upstream regulator of SOX4, which is abrogated in HCC cells and exerts degenerating effect on SOX4 mRNA. In our conclusion, Anillin facilitates the cell proliferation and enhances tumor growth of HCC, and is modulated by miR-138/SOX4 axis which regulates the transcriptional activity of Anillin. +genetics_overexpression_suppress 32645222 hsa-mir-219a Vertigo In summary, in rats with acute vertigo, miR-219a-5p overexpression inhibits CaMKIIgamma and elevates PKC, thereby facilitating VC. +lncRNA target 32645138 hsa-mir-28 Esophageal Squamous Cell Carcinoma 5p may induce cell proliferation and suppress apoptosis to promote EC tumor formation via decreasing MTSS1 expression. +circulation_biomarker_diagnosis_up 32644942 hsa-mir-126 Brain Ischemia 5p and relevant downstream cytokines in brain tissue among different groups, and investigated the improvement in cerebral blood perfusion (ICBP) and the recovery of cognitive function (RCF). +circRNA target 32644859 hsa-mir-409 Uterine Cervical Neoplasms 3p hindered CC progression by targeting ATF1. +other 32644852 hsa-mir-590 Nasopharyngeal Carcinoma 3p were highly expressed (p < 0.01). +other 32644852 hsa-mir-379 Nasopharyngeal Carcinoma 3p were highly expressed (p < 0.01). +other 32644852 hsa-mir-4320 Nasopharyngeal Carcinoma 3p were highly expressed (p < 0.01). +other 32644852 hsa-mir-498 Nasopharyngeal Carcinoma 3p were highly expressed (p < 0.01). +other 32644852 hsa-mir-3529 Nasopharyngeal Carcinoma 3p were highly expressed (p < 0.01). +target gene 32644822 hsa-mir-147a Uterine Cervical Neoplasms LINC00319 Promotes Cervical Cancer Progression Via Targeting miR-147a/IGF1R Pathway. +exosome 32644821 hsa-mir-421 Glioma Conclusion: Exosomal circ-HIPK3 could promote cell progression and TMZ resistance by regulating miR-421/ZIC5 axis in TMZ-resistant glioma. +genetics_GWAS 32644049 hsa-mir-217 Colonic Neoplasms HIF-1alpha axis may serve as a novel diagnostic and prognostic biomarker for patients with colon cancer. +other 32644005 hsa-mir-375 Lung Diseases 3p in the development of lung diseases. +genetics_overexpression_promote 32643867 hsa-mir-532 Osteosarcoma 5p on OS cell were rescued by CXCL2 overexpression. +other 32643848 hsa-mir-1343 Adenocarcinoma of Lung 3p to upregulate the TGFBR1 expression and promote the EMT and metastasis in LUAD. +genetics_knock down_suppress 32643321 hsa-mir-498 Esophageal Squamous Cell Carcinoma Both TMPO-AS1 overexpression and miR-498 knockdown weakened the effect of propofol on hypoxia-induced EC cell progression. +other 32643116 hsa-mir-20b Cervical Intraepithelial Neoplasia In the HPV16-positive subsets of the samples (n = 13), miR-20b showed 2.9-times elevation (p < 0.001), whereas miR-515 was 1.15-times downregulated (p < 0.05) in CIN2-3 as compared to normal tissue. +circulation_biomarker_diagnosis_up 32642701 hsa-mir-371a Neoplasms, Germ Cell and Embryonal The benefits would have included (1) the only confirmatory evidence of an intracranial malignant GCT in 1 case, supporting clinical decision making; (2) early detection of intracranial malignant GCT in another, where an elevated CSF miR-371a-3p level preceded the histologically confirmed diagnosis by 2 years; and (3) confirmation of an intracranial malignant GCT relapse with an elevated serum miR-371a-3p level, where serum and CSF AFP and HCG levels were below thresholds for such a diagnosis. +circulation_biomarker_diagnosis_ns 32642701 hsa-mir-371 Neoplasms, Germ Cell and Embryonal MicroRNAs from the miR-371~373 and miR-302/367 clusters are over-expressed in all malignant GCTs and, in particular, miR-371a-3p shows elevated serum levels at diagnosis for testicular disease. +lncRNA target 32642700 hsa-mir-93 Glioblastoma Phenotypically, re-expression of miR-93 in GBM cells substantially suppressed proliferation, migration, and angiogenesis. +target gene 32642410 hsa-mir-142 Breast Neoplasms MiR-142-3p enhances chemosensitivity of breast cancer cells and inhibits autophagy by targeting HMGB1. +genetics_overexpression_promote 32642297 hsa-mir-205 Breast Neoplasms miR-205 overexpression could inhibit breast cancer malignancy by regulating RunX2 both in vitro and in vivo. Together, our results support that miR-205 is a tumor suppressor during breast cancer development. +genetics_knock down_suppress 32642169 hsa-mir-181a Hypoxia LYRM1 knockdowns inhibited miR-181a-inhibitor's protective effects for cardiac progenitor cell functions in hypoxia. +other 32642095 hsa-mir-17 Adenocarcinoma of Lung 5p and PLSCR4 have a significant negative co-expression relationship (r=-0.33, P=1.67e-14) in LUAD. +genetics_GWAS 32641995 hsa-mir-139 Colorectal Neoplasms 5p was significantly downregulated in KRAS-mutated CRC cells and tissues compared with their wild-type counterparts. +transcription factor target 32641987 hsa-mir-1291 Carcinogenesis Results: The expression of miR-1291 inhibited growth and tumorigenesis as a result of modulation of metabolism. +other 32641987 hsa-mir-1291 Breast Neoplasms ESRRA was identified as a prominent differentially expressed gene in both breast and pancreatic cancer samples, and estrogen-related receptor alpha (ERRalpha) was found to link miR-1291 and CPT1C. +lncRNA target 32641854 hsa-let-7c Carcinoma, Non-Small-Cell Lung Recent work has revealed the role that miRNAs, particularly tumor suppressor let-7c, play in the invasiveness and acquired resistance of NSCLCs, but the mechanistic details, particularly in Osimertinib resistance, remain elusive. Our results suggest an important role of let-7c in regulating EMT and the resulting Osimertinib resistance in T790M NSCLCs. +transcription factor target 32641685 hsa-mir-4652 Nasopharyngeal Carcinoma 3p was found to be a downstream inducer of SPEN by targeting the homeodomain interacting protein kinase 2 (HIPK2) gene, a potential tumor suppressor that reduces the activation of epithelial-mesenchymal transition (EMT) signaling, thereby reducing its expression and leading to increased NPC migration, invasion, and metastasis. +circulation_biomarker_diagnosis_ns 32641679 hsa-mir-512 Retinoblastoma This study aimed to explore the endoplasmic reticulum stress (ERS) and drug resistance of RB and verify the effect of miR +transcription factor target 32641100 hsa-mir-133 Renal Insufficiency, Chronic pLV-miR-294/pLV-miR-133 mimic/inhibitor were injected into young and old rats before UUO to detect the effects of miR-294/miR-133, which were decreased in MSC-EVs and sera from old rats, on renal function in CKD. +transcription factor target 32641100 hsa-mir-294 Renal Insufficiency, Chronic pLV-miR-294/pLV-miR-133 mimic/inhibitor were injected into young and old rats before UUO to detect the effects of miR-294/miR-133, which were decreased in MSC-EVs and sera from old rats, on renal function in CKD. +genetics_knock down_promote 32640974 hsa-mir-598 Ovarian Neoplasms CONCLUSION: Knockdown of circCELSR1 inhibited BRD4-mediated proliferation/migration related signaling via sponging miR-598, thereby repressing ovarian cancer progression. +genetics_knock down_promote 32640404 hsa-mir-526b Colorectal Neoplasms Moreover, CCND1 was a target of miR-526b-3p, and its overexpression could reverse the inhibitory effect of miR-526b-3p overexpression on the proliferation, migration, and invasion of CRC cells. +genetics_GWAS 32640303 hsa-mir-146a Lung Neoplasms CONCLUSION miR-146a rs2910164 G>C polymorphism may be a risk factor of lung cancer. +lncRNA target 32640195 hsa-mir-124 Liver Neoplasms In conclusion, our findings revealed the crucial role of the miR-124 in liver CSCs expansion and sorafenib response, rendering miR-124 an optimal target for the prevention and intervention in HCC. +circulation_biomarker_diagnosis_ns 32639875 hsa-mir-203a Muscular Disorders, Atrophic Finally, EV miR-203a-3p expression was significantly decreased in human subjects who underwent unilateral lower limb suspension (ULLS) to induce muscle atrophy. Altogether, we show that serum EV miR-203a-3p expression is related to skeletal muscle protein turnover and atrophy. +genetics_knock down_suppress 32639657 hsa-mir-4 Colorectal Neoplasms Furthermore, in the rescue functional assay, miR-4,668-3p down-regulation exacerbated the malignant behaviors of AGAP2-AS1-depleted CRC cells, whereas such effects were further offset by SRSF1 knockdown. +lncRNA target 32639636 hsa-mir-1911 Squamous Cell Carcinoma of Head and Neck As indicated from the mentioned findings, IGKJ2-MALLP2, which mediates p21 expression by targeting miR3p, was capable of regulating LSCC progression and could act as an underlying therapeutic candidate to treat LSCC. +circulation_biomarker_prognosis_up 32639004 hsa-mir-720 Glioma The high plasma miR-720 was related to adverse prognosis in patients with glioma and could be a prognosis predictor of glioma patients. +other 32638751 hsa-mir-21 Uterine Cervical Neoplasms Furthermore, this biosensor can determine miRNA-21 expression in cell lysates of 100 human cervical cancer (HeLa) cells. +lncRNA target 32638620 hsa-mir-363 Stomach Neoplasms 3p/HMGA2 axis in GCSC progression, providing a potential therapeutic target for GC. +circulation_biomarker_diagnosis_up 32638565 hsa-mir-1165 Allergic Inflammation 3p up-regulation was accompanied by reduced airway hyper-responsiveness, serum immunoglobulin E, airway inflammation and Th2-cell polarization. +lncRNA target 32638404 hsa-mir-374a Ovarian Neoplasms Moreover, rescue assay was carried out to confirm whether LINC-PINT contributes to the development of OC cells through targeting miR-374a-5p. +transcription factor target 32638262 hsa-mir-210 Sepsis Interference with miR-210 alleviated renal injury in septic rats by inhibiting JAK-STAT pathway. +circulation_biomarker_diagnosis_ns 32637920 hsa-mir-204 Familial Mediterranean Fever CONCLUSION: Our findings showed significant alterations in the plasma expression of miRNA-155 and miRNA-204 in FMF patients compared to HCs. +circulation_biomarker_diagnosis_ns 32637863 hsa-mir-185 Endometriosis 5p in the plasma of women with endometriosis could be employed as an important non-invasive biomarker for early detection and screening of endometriosis by blood samples. +genetics_overexpression_suppress 32637582 hsa-mir-7 Breast Neoplasms This study aimed to present evidence that miR-7 inhibited the metastasis of breast cancer stem cells (BCSCs) and elucidated the mechanisms that have remained unknown. Our data demonstrated that miR-7 overexpression reduced the metastasis of BCSCs via inhibiting ESAM, suggesting that ESAM could be a potential target for breast cancer therapy. +other 32637580 hsa-mir-21 Neoplasms, Multiple Primary In this study, we confirmed that the expression of miR-21 was significantly increased in multiple tumors. +epigenetics 32637580 hsa-mir-21 nonpapillary renal cell carcinoma We also confirmed MIR21 hypomethylation by pyrosequencing of fresh clear cell renal cell carcinoma (ccRCC) samples. +transcription factor target 32637572 hsa-mir-29 Stomach Neoplasms Among these targets, the COL4A1 gene ranked at the top in the association analysis of combined miR-29s biological function and GC subtype, and miR-29s inhibited its translation by binding to the 3' UTR region. The miR-29s regulatory network may affect the development of growth patterns and pathological progress of GC by regulating the function of COL4A1. +genetics_overexpression_promote 32637414 hsa-mir-98 Liver Cirrhosis miR-98 overexpression in vivo by ago-miR-98 injection could attenuate CCl(4)-, BDL-, and HFD-induced murine hepatic fibrosis. +genetics_overexpression_promote 32636722 hsa-mir-1587 Colorectal Neoplasms Taken together, we show that miR-1587 overexpression enhances the formation of DSBs, arrests CRC cell growth, and enhances the radiosensivity of CRC cells through the direct repression of LIG4 expression. +lncRNA target 32636681 hsa-mir-582 Stomach Neoplasms CONCLUSION: MiR-582 induced by GATA6-AS1 silencing promotes the growth and metastasis of GC cells by targeting FOXO3 to induce the activation of the PI3K/AKT/Snail signaling pathway. +therapeutic target 32636650 hsa-mir-193a Colorectal Neoplasms CircRNA hsa_circ_0001806 may act as a promising therapeutic target by facilitating the stemness of CRC cells via activating the hsa_circ_0001806/miR-193a-5p/COL1A1 axis. +target gene 32636648 hsa-mir-4775 Lung Neoplasms LncRNA SLC7A11-AS1 Contributes to Lung Cancer Progression Through Facilitating TRAIP Expression by Inhibiting miR-4775. +target gene 32636647 hsa-mir-182 Stomach Neoplasms Down-Regulation of circNRIP1 Promotes the Apoptosis and Inhibits the Migration and Invasion of Gastric Cancer Cells by miR-182/ROCK1 Axis. +transcription factor target 32636645 hsa-mir-335 Adenocarcinoma of Lung CONCLUSION: In summary, our results revealed that miR5p could target the down-regulation of CCNB2 to inhibit the occurrence and development of LUAD. +lncRNA target 32636644 hsa-mir-125b Melanoma And miR-125b-5p/RAB3D signaling is crucial for CAR10-dependent melanoma progression. CONCLUSION: Our work suggests that lncRNA CAR10 promotes melanoma growth and metastasis through modulating miR-125b-5p/RAB3D axis. +other 32636641 hsa-mir-507 Carcinoma, Hepatocellular circ_0005394 Predicts Unfavorable Prognosis and Contributes to Hepatocellular Carcinoma Progression by Regulating miR-507/E2F3 and miR-515-5p/CXCL6 Signaling Pathways. +lncRNA target 32636639 hsa-mir-128 Carcinoma, Non-Small-Cell Lung CONCLUSION: LOXL1-AS1 promotes the progression of NSCLC by regulating miR-3128/RHOXF2 axis, which might be a new potential target for the diagnosis and treatment of NSCLC. +transcription factor target 32635855 hsa-mir-96 Endometriosis 5p inhibitors or TGFBR1 siRNA. +other 32635855 hsa-mir-96 Uterine Diseases MiR5p was significantly downregulated in ectopic endometrial tissues compared to eutopic tissues. +transcription factor target 32635799 hsa-mir-365a Carcinoma, Non-Small-Cell Lung Aim: Demonstrate the function of dysregulated miR-365a-5p-PELI3 signaling axis in the generation of gefitinib resistance during treatment for non-small-cell lung cancer (NSCLC). Conclusion: Dysregulated miR-365a-5p-PELI3 signaling axis triggered the generation of gefitinib resistance in NSCLC. +genetics_GWAS 32635763 hsa-mir-150 Osteoarthritis In conclusion, our findings highlight the function and prognostic value of LINC00511/miR5p/SP1 feedback loop in OA and extend the importance of lncRNA epigenetics in OA biology. +genetics_GWAS 32635759 hsa-mir-15b Esophageal Squamous Cell Carcinoma We found that miR-15b SNP rs1451761T>G was associated with a significantly decreased risk of ESCC and there was a significant SNP-SNP interaction between rs1451761 and rs2740545. Our results suggest that miR-15b SNP rs1451761 may affect an individual's susceptibility to ESCC, alone and in SNP-SNP and SNP-smoking interaction manners. +transcription factor target 32635504 hsa-mir-101 Vascular Diseases Because a previous study reported that miR-101, a tumor-suppressive miRNA, is a critical regulator of cell proliferation in vascular disease, we hypothesized that miR-101 controls important cellular processes in VSMCs. +genetics_GWAS 32635336 hsa-mir-9 Glioblastoma Taken together, our results indicate that miR-9, functioning as a tumor-suppressive miRNA in GBM, is suppressed through epigenetic silencing by EZH2. +circulation_biomarker_diagnosis_ns 32634817 hsa-mir-1 Cardiomyopathies CONCLUSION: Plasma hs-cTnT and circulating miR-1 may be useful markers of myocardial damage during chemotherapy in children with leukaemias. The study provides the first evidence of progressive increase in circulating miR-1 and plasma hs-cTnT levels during the course of anthracycline-based therapy in children with leukaemias, with hs-cTnT level also associated with changes in LV myocardial deformation. +circulation_biomarker_diagnosis_ns 32634817 hsa-mir-1 Leukemia CONCLUSION: Plasma hs-cTnT and circulating miR-1 may be useful markers of myocardial damage during chemotherapy in children with leukaemias. The study provides the first evidence of progressive increase in circulating miR-1 and plasma hs-cTnT levels during the course of anthracycline-based therapy in children with leukaemias, with hs-cTnT level also associated with changes in LV myocardial deformation. +circulation_biomarker_diagnosis_up 32634427 hsa-mir-155 Thrombocytopenia 5p and SOCS1 in peripheral blood mononuclear cells (PBMCs) and macrophages from ITP patients. +circulation_biomarker_diagnosis_up 32634388 hsa-mir-210 Mucocutaneous Lymph Node Syndrome RESULTS: KD patients (3.6 /- 2.2 yrs., 58% male) were found to have a unique circulating miRNA profile, including upregulation of miRNA3p, -184, and -19a-3p (p < .0001), compared to non-KD febrile controls (8.5 /- 6.1 yrs., 72% male). +circulation_biomarker_diagnosis_up 32634388 hsa-mir-210 Cardiovascular Diseases RESULTS: KD patients (3.6 /- 2.2 yrs., 58% male) were found to have a unique circulating miRNA profile, including upregulation of miRNA3p, -184, and -19a-3p (p < .0001), compared to non-KD febrile controls (8.5 /- 6.1 yrs., 72% male). +transcription factor target 32634201 hsa-mir-133a Aortic Dissection In conclusion, our present results indicated that the upregulation of miR-133a by APN inhibits pyroptosis pathway, which potentially rescues AAD. +lncRNA target 32634132 hsa-let-7 Prostatic Neoplasms This study revealed a mechanism by which t-NEPC can develop through the LIN28B/let-7/SOX2 axis that regulates a cancer cell stem-like gene network, highlighting LIN28B as a potential therapeutic target in t-NEPC. +other 32634115 hsa-mir-21 Diabetes Mellitus These findings suggest that miR3p may treat DFU by reducing SPRY1. +lncRNA target 32633726 hsa-mir-141 Colonic Neoplasms PHLPP2 upregulation and miR-141 and miR-424 downregulation suppressed the colon cancer cell proliferation, migration, invasion, and epithelial-mesenchymal transition, and promote cell apoptosis, which also resulted in suppression of tumor metastasis and formation. +lncRNA target 32633726 hsa-mir-424 Colonic Neoplasms PHLPP2 upregulation and miR-141 and miR-424 downregulation suppressed the colon cancer cell proliferation, migration, invasion, and epithelial-mesenchymal transition, and promote cell apoptosis, which also resulted in suppression of tumor metastasis and formation. +genetics_overexpression_promote 32633635 hsa-mir-7 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Finally, microRNA-7 overexpression reduces growth, motility, and migration while inducing apoptosis in T-cell acute lymphoblastic leukemia cells, phenotypes that can be rescued by concomitant overexpression of TAL1. +other 32633566 hsa-mir-101 Renal Insufficiency, Chronic In this study, a murine model of renal ischemia/reperfusion was established to investigate the repairing effect and mechanism of miR-101a-3p on renal injury. Our study indicates that miR-101 is an anti-EMT miRNA, which provides a novel therapeutic strategy for AKI-CKD transition. +other 32633566 hsa-mir-101 Acute Kidney Injury In this study, a murine model of renal ischemia/reperfusion was established to investigate the repairing effect and mechanism of miR-101a-3p on renal injury. Our study indicates that miR-101 is an anti-EMT miRNA, which provides a novel therapeutic strategy for AKI-CKD transition. +other 32633423 hsa-mir-200c Stomach Neoplasms CONCLUSION: The upregulation of mir-200c-3p and mir-520c-3p could effect on stemness and metastasis in gastric cancer as well as gastric CSCs. +other 32633423 hsa-mir-520c Stomach Neoplasms CONCLUSION: The upregulation of mir-200c-3p and mir-520c-3p could effect on stemness and metastasis in gastric cancer as well as gastric CSCs. +other 32633423 hsa-mir-34a Stomach Neoplasms In AGS spheres, however, miR-520c-3p and miR-200c-3p upregulation and miR-34a-5p downregulation were similar to grade II tumors. +exosome 32633398 hsa-mir-106a Angelman Syndrome We found that the exosomes-mediated miR-106a-3p could directly bind with CASP9 and repress Caspase signaling pathway in VSMCs, which might provide a potential target for treating AS. +circulation_biomarker_diagnosis_up 32633397 hsa-mir-216b Carotid Artery Diseases CONCLUSIONS: Detection of serum levels of CCAT2 and miRNA-216b could be applied for predicting the rupture of carotid atherosclerotic plaques. +lncRNA target 32633396 hsa-mir-508 Angelman Syndrome 5p indicated that ZNF295-AS1 may be an upstream suppressor of miR +lncRNA target 32633395 hsa-mir-19a Angelman Syndrome Furthermore, silencing miR-19a inhibited the proliferation and invasion of ASVEC. +lncRNA target 32633392 hsa-mir-6322 Myocardial Reperfusion Injury We also confirmed that PARP2 was the target of miR-6322 in I/R injury. +other 32633390 hsa-mir-23 Myocardial Infarction 3p agomir in rats with MI, the cardiac function of the rats was significantly improved. +transcription factor target 32633388 hsa-mir-22 Aortic Aneurysm, Thoracic 3p can inhibit the expression of MMP-9, thus suppressing the formation of TAA in rats. +circulation_biomarker_diagnosis_up 32633381 hsa-mir-1 Multiple Sclerosis 3p in periphery blood mononuclear cells (PBMC), cerebrospinal fluid (CSF), CD4+ T cells, CD8+ T cells, non-T cells and differentiated CD4+ T cells derived from healthy donors and MS patients during remitted and relapsed stages was detected. +lncRNA target 32633379 hsa-mir-17 Diabetic Nephropathies CONCLUSIONS: Above that, we found that lncRNA PAX8-AS1-N/miR5p/STAT3 axis was closely related the progression of DN, which could be a potential target for treating DN patients. +circRNA target 32633377 hsa-mir-620 Glioma CONCLUSIONS: These data suggest that circ-ABCB10 affects glioma progression by regulating the miR-620/FABP5 axis, and circ-ABCB10 might be used as a potential target for the treatment of glioma. +genetics_knock down_promote 32633376 hsa-mir-105 Glioma Interestingly, the overexpression of VIM-AS1 reversed the tumor-suppressing role of miR +genetics_overexpression_promote 32633375 hsa-mir-381 Glioblastoma In addition, the overexpression of miR-381 restrained migration and invasion of glioblastoma cells. +lncRNA target 32633371 hsa-mir-605 Breast Neoplasms CONCLUSIONS: We identified the downregulation of circDDX17 in breast cancer, and circDDX17 acted as a tumour suppressor by inhibiting proliferation and promoting apoptosis through its function as a sponge of miR-605 in breast cancer, indicating that it serves as a potential biomarker and a therapeutic target for breast cancer. +lncRNA target 32633369 hsa-mir-151a Lung Neoplasms CONCLUSIONS: Both miR-151a-5p and miR-23b are highly expressed in lung cancer, and the inhibition of miR-151a-5p and miR-23b can restrain the proliferation, invasion and migration of lung cancer A549 cells, thereby promoting the apoptosis of lung cancer A549 cells. +lncRNA target 32633369 hsa-mir-23b Lung Neoplasms CONCLUSIONS: Both miR-151a-5p and miR-23b are highly expressed in lung cancer, and the inhibition of miR-151a-5p and miR-23b can restrain the proliferation, invasion and migration of lung cancer A549 cells, thereby promoting the apoptosis of lung cancer A549 cells. +genetics_overexpression_promote 32633368 hsa-mir-185 Lung Neoplasms 5p overexpression inhibited the WNT1 expression, while circFOXP1 repression decreased the WNT1 level in LUAD cell lines. +other 32633367 hsa-mir-145 Lung Neoplasms CONCLUSIONS: B7-H3 and miR-145 are abnormally expressed in lung cancer, and are closely related to the lymphatic metastasis, differentiation degree and TNM stage of lung cancer. +other 32633367 hsa-mir-145 Pleural Effusion, Malignant CONCLUSIONS: B7-H3 and miR-145 are abnormally expressed in lung cancer, and are closely related to the lymphatic metastasis, differentiation degree and TNM stage of lung cancer. +genetics_overexpression_promote 32633366 hsa-mir-539 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: LINC00460 is overexpressed in NSCLC tissues and can promote the growth of NSCLC cells by targeting miR-539. +other 32633365 hsa-mir-141 Nasopharyngeal Carcinoma CONCLUSIONS: SNHG15 is upregulated in NPC tissues, and this aggravates the progression of NPC by absorbing miR3p to upregulate KLF9. +genetics_overexpression_promote 32633361 hsa-mir-936 Stomach Neoplasms CONCLUSIONS: Overexpression of microRNA-936 can be conducive to the development of GCa, mainly through the down-regulation of FGF2 and activation of the P13K/Akt signaling pathway. +other 32633360 hsa-mir-769 Stomach Neoplasms 5p is upregulated in GC and positively correlated with TNM stage in GC patients. +genetics_knock down_suppress 32633359 hsa-mir-615 Stomach Neoplasms Notably, knockdown of miR +lncRNA target 32633358 hsa-mir-21 Colorectal Neoplasms Bioinformatics prediction and luciferase assay indicated that miR-21c is a direct target of SLC30A10, which plays the role of ceRNA in regulating colorectal cancer metastasis. SLC30A10 inhibits colorectal cancer progression and metastasis by acting as a ceRNA for miR-21c to regulate APC expression, suggesting that SLC30A10 may serve as a potential prognostic biomarker and anti-metastatic therapeutic target for colorectal cancer. +genetics_knock down_suppress 32633357 hsa-mir-502 Stomach Neoplasms 3p knockdown reversed the inhibitory effect of circ_0032627 on the proliferation of GC cells. +genetics_overexpression_promote 32633355 hsa-mir-593 Carcinoma, Hepatocellular HCC cells were, then, transfected with miR-593 mimic to exogenously overexpress miR-593. +genetics_overexpression_promote 32633351 hsa-mir-200c Wilms Tumor Flow cytometry results revealed that miR-200c overexpression significantly elevated the apoptosis rate of Wilms tumor cells (p<0.05). +other 32633346 hsa-mir-210 Uterine Cervical Neoplasms 3p produces a pronounced diagnostic efficacy, so it can be utilized as a novel hallmark for diagnosing CC and predicting the disease progression. +lncRNA target 32633345 hsa-mir-613 Uterine Cervical Neoplasms CONCLUSIONS Taken all, this research discovered the function of miR-613 on CSCC by targeting LETM1, revealing that miR-613/LETM1 signal pathway might be a potential therapeutic target for the diagnosis and treatment of CSCC. +target gene 32633336 hsa-mir-205 Inflammation MiR3p inhibited inflammation and oxidative stress in HCE cells induced by UV radiation (p < 0.01). +other 32633336 hsa-mir-205 Corneal Injuries This paper aimed to study the effect of miR3p on corneal damage induced by ultraviolet (UV) radiation. +other 32633336 hsa-mir-205 Corneal Diseases This paper aimed to study the effect of miR3p on corneal damage induced by ultraviolet (UV) radiation. +lncRNA target 32633335 hsa-mir-204 Diabetic Retinopathy No treatment was performed in the normal group, the diabetic retinopathy model was established in model group, and miR-204 mimics were administered for intervention after modeling in the inhibitor group. CONCLUSIONS: MiR-204 up-regulates Bcl-2 and SIRT1 expressions to inhibit the inflammation and cell apoptosis in rats with diabetic retinopathy. +lncRNA target 32633335 hsa-mir-204 Retinal Diseases No treatment was performed in the normal group, the diabetic retinopathy model was established in model group, and miR-204 mimics were administered for intervention after modeling in the inhibitor group. CONCLUSIONS: MiR-204 up-regulates Bcl-2 and SIRT1 expressions to inhibit the inflammation and cell apoptosis in rats with diabetic retinopathy. +lncRNA target 32633323 hsa-mir-532 Stomach Neoplasms CONCLUSION circFGD4 suppressed GC progression through sponging miR +lncRNA target 32633150 hsa-mir-663a Osteosarcoma Through a series of biological experiments, it was found that miR-663a regulates the cellular process in osteosarcoma by modulating the expression of MYL9. +transcription factor target 32632603 hsa-mir-133a Neuralgia In vivo, the association between miR-133a-3p with DNP was analyzed via AAV-miR-133a-3p intraneural (intra-epineural but extrafascicular) injection into the sciatic nerve of normal rats or injection of an miR-133a-3p antagomir into the sciatic nerve of diabetes mellitus (DM) rats. In DM rats, miR-133a-3p antagomir administration alleviated DNP and downregulated p-p38 phosphorylation. +genetics_overexpression_promote 32632270 hsa-mir-181c Ovarian Neoplasms Furthermore, the delivery of overexpressed miR-181c by BMSCs-derived EVs was found to suppress the resistance of ovarian cancer cells to DDP. +circRNA target 32632266 hsa-mir-129 Cardiomegaly Moreover, we verified circ-Jarid2 contributed to cardiac hypertrophy via miR +lncRNA target 32632205 hsa-mir-195 Alzheimer Disease Together, our data uncover a novel regulatory mechanism of miR-195 targeted at ApoE4-associated brain PIP(2) dyshomeostasis, cognitive deficits, and AD pathology. +transcription factor target 32632129 hsa-mir-450b Nasopharyngeal Carcinoma Mechanistically, miR-450b-5p, being positively regulated by RKIP in NPC cells, could sensitize NPC cells to irradiation by directly targeting and suppressing the level of NRF2. +lncRNA target 32632096 hsa-mir-21 Multiple Myeloma targeting strategies to counteract microenvironment dependence of MM growth and bone disease. +lncRNA target 32632040 hsa-mir-146b high grade glioma SMARCA5, which is highly expressed in high-grade gliomas, was a direct downstream target of miR-146b-5p in the GSC/MSC fusion cells. Collectively, these findings demonstrate that miR-146b-5p suppresses the malignant phenotype of GSC/MSC fusion cells in the glioma microenvironment by targeting a SMARCA5-regulated TGF-beta pathway. +circulation_biomarker_diagnosis_up 32631807 hsa-mir-223 Allergic Inflammation 3p was measured in the serum of 41 allergic rhinitis patients and 39 healthy controls using quantitative real time polymerase chain reaction. +other 32631422 hsa-mir-21 Hypercholesterolemia Participants will undergo a medical evaluation and chemical-clinical examinations, which include lipid profile, glycemia, biomarkers of renal, liver and cardiac/muscular functions, interleukins (IL 6, IL-32, IL-37, and IL-38), and innovative mediators of inflammation such as inflamma-miRs (miR-21 and miR-146a), at baseline, and after 6 and 12 weeks of treatment. +other 32631422 hsa-mir-146a Hypercholesterolemia Participants will undergo a medical evaluation and chemical-clinical examinations, which include lipid profile, glycemia, biomarkers of renal, liver and cardiac/muscular functions, interleukins (IL 6, IL-32, IL-37, and IL-38), and innovative mediators of inflammation such as inflamma-miRs (miR-21 and miR-146a), at baseline, and after 6 and 12 weeks of treatment. +lncRNA target 32631421 hsa-mir-142 Uterine Cervical Neoplasms We previously showed that metformin disrupts the sponge effect of long non-coding RNA MALAT1/miR3p to inhibit cervical cancer cell proliferation. +transcription factor target 32631271 hsa-mir-221 Breast Neoplasms Our previous work has revealed that miR-221/222 plays important role in regulating breast cancer development and progression through interaction with target gene p27. CONCLUSIONS: We demonstrated the attenuated interaction between miR-221/222 and p27 by starvation-induced stress in MDA-MB-231 breast cancer cells. +transcription factor target 32631271 hsa-mir-222 Breast Neoplasms Our previous work has revealed that miR-221/222 plays important role in regulating breast cancer development and progression through interaction with target gene p27. CONCLUSIONS: We demonstrated the attenuated interaction between miR-221/222 and p27 by starvation-induced stress in MDA-MB-231 breast cancer cells. +transcription factor target 32631202 hsa-mir-22 Neointima Curcumin increased miR-22 (46%, p < 0.01), decreased the SP1 protein (19%, p < 0.05), and inhibited vascular neointimal area (48%, p < 0.01) in vivo.Discussion: The miR-22/SP1 pathway is involved in the protective role of curcumin during arterial balloon injury, but the mechanisms remain unclear.Conclusion: miR-22 is involved in the inhibitory effects of curcumin on VSMCs' proliferation, migration and neointima hyperplasia after arterial balloon injury in rats. +circulation_biomarker_diagnosis_up 32631160 hsa-mir-29b Hypertension CONCLUSION: Our results provided a clinical evidence of a positive association between circulating miR-29b, inflammatory markers, and UACR, and implied miR-29b was a significant independent determinant factor for albuminuria. +other 32630813 hsa-mir-34a Pulmonary Fibrosis Thus, SIRT1 may mediate, miR34a-regulated, persistent FLIP levels by deacetylation of Ku70 in lung myofibroblasts, promoting resistance to cell-death and lung fibrosis. +other 32630692 hsa-mir-133a psoriasis 1 After treatment, expression of miR-133a-3p, miR-375, miR-378a and miR-135b in residual lesions returned towards the levels observed in non-lesional skin. +other 32630692 hsa-mir-378a psoriasis 1 After treatment, expression of miR-133a-3p, miR-375, miR-378a and miR-135b in residual lesions returned towards the levels observed in non-lesional skin. +lncRNA target 32630692 hsa-mir-135b psoriasis 1 The decrease in miR-135b levels after treatment with biologics was associated with both the improvement of patients evaluated through Psoriasis Area and Severity Index score and the decrease in local inflammatory response. Moreover, basal expression of miR-135b along with age was associated with the improvement of psoriasis, suggesting its possible usefulness as a prognostic biomarker. +other 32630692 hsa-mir-375 psoriasis 1 After treatment, expression of miR-133a-3p, miR-375, miR-378a and miR-135b in residual lesions returned towards the levels observed in non-lesional skin. +circulation_biomarker_prognosis_up 32630552 hsa-mir-192 Carcinoma, Pancreatic Ductal 5p was deregulated in PDAC as compared to healthy controls (HCs), with downregulation in macrodissected tissue (p < 0.001) and upregulation in blood serum of PDAC UICC (Union for International Cancer Control) stage IV (p = 0.016) and serum exosomes of PDAC UICC stages II to IV (p < 0.001). +circulation_biomarker_diagnosis_ns 32630479 hsa-mir-122 Hepatitis C The purpose of this study was to investigate the impact of peginterferon alpha (pegIFN-alpha) and ribavirin treatments on the expression of miR-122 and the cholesterol level in the peripheral blood mononuclear cells (PBMCs) of CHC patients. Consequently, it seems that the decrease of miR-122 expression in the PBMCs of CHC patients is one of the antiviral effects connected with the pegIFN-alpha/ribavirin treatments. +other 32629683 hsa-mir-151a Myelodysplastic Syndromes 3p, and miR-550a-3p) were significantly downregulated in MDS. +other 32629683 hsa-mir-181a-2 Myelodysplastic Syndromes 3p, and miR-550a-3p) were significantly downregulated in MDS. +other 32629683 hsa-mir-124 Myelodysplastic Syndromes 3p, and miR-550a-3p) were significantly downregulated in MDS. +other 32629683 hsa-mir-146a Myelodysplastic Syndromes 3p, and miR-550a-3p) were significantly downregulated in MDS. +other 32629683 hsa-mir-125b Myelodysplastic Syndromes 3p, and miR-550a-3p) were significantly downregulated in MDS. +other 32629683 hsa-mir-550a Myelodysplastic Syndromes 3p, and miR-550a-3p) were significantly downregulated in MDS. +lncRNA target 32629426 hsa-mir-145 Aortic Aneurysm, Abdominal Taken together, the present study provides evidence that downregulation of lncRNA Sox2ot suppressed the expression of Egr1 through regulating miR-145, thus inhibiting the development of AAA, highlighting a theoretical basis for AAA treatment. +genetics_GWAS 32629323 hsa-mir-686 Autoimmune Diseases Taken together, our study revealed that Gm15575-miR-686 axis promoted the progression of EAE by regulating Th17 differentiation and expression of CCL7 which elucidated the pathogenesis of autoimmune diseases at genetic level. +genetics_GWAS 32629323 hsa-mir-686 Encephalomyelitis, Autoimmune, Experimental Taken together, our study revealed that Gm15575-miR-686 axis promoted the progression of EAE by regulating Th17 differentiation and expression of CCL7 which elucidated the pathogenesis of autoimmune diseases at genetic level. +circulation_biomarker_diagnosis_ns 32629237 hsa-mir-155 Depression, Postpartum N-3 PUFA inhibited neuroinflammation by decreasing circulating levels of prostaglandin E(2) and hippocampal expression of tumor necrosis factor-alpha, interleukin-6, and miRNA-155. +circulation_biomarker_diagnosis_ns 32629210 hsa-mir-200c Pituitary Diseases MiR-200c-3p was strongly linked with endothelial function and its level is increased in serum of fluorosis patients, but it is unclear the role of miR-200c-3p in the fluoride induced endothelial dysfunction. +circulation_biomarker_diagnosis_ns 32629210 hsa-mir-200c Fluorosis, Dental MiR-200c-3p was strongly linked with endothelial function and its level is increased in serum of fluorosis patients, but it is unclear the role of miR-200c-3p in the fluoride induced endothelial dysfunction. +genetics_knock down_suppress 32629066 hsa-mir-432 Glioma CONCLUSION: circ-PTN knockdown repressed cell proliferation, invasion and glycolysis in glioma via modulating miR +genetics_knock down_suppress 32629026 hsa-mir-448 Triple Negative Breast Neoplasms The knockdown of circ-ZEB1 was proven to inhibit TNBC cell proliferation and tumor growth via releasing miR-448, and subsequently reducing the expression of the miR-448 target, eEF2K. +lncRNA target 32628792 hsa-mir-196a Prostatic Neoplasms miR-196a and its target p27(kip1) may become novel molecular biomarkers and therapeutic targets for PCa. +lncRNA target 32628541 hsa-mir-21 Carcinoma, Renal Cell These results suggested that miR-21 promoted calcium oxalate-induced renal tubular cell injury by targeting PPARA, indicating that miR-21 could be a potential therapeutic target and biomarker for nephrolithiasis. +lncRNA target 32628059 hsa-mir-342 Glioma AKT2 was the target gene of miR +circulation_biomarker_diagnosis_up 32627968 hsa-mir-133b Urinary Bladder Neoplasms The level of miR-133b was significantly decreased in BC tissues and in exosomes from serum of patients, which was correlated with poor overall survival in TCGA. +genetics_knock down_promote 32627938 hsa-mir-33a Carcinoma, Hepatocellular Furthermore, TGFbeta2 was demonstrated to be a target gene of miR-33a and TGFbeta2 overexpression rescued the phenotypes of HCC cells attenuated by miR-33a mimics. +genetics_knock down_promote 32627866 hsa-mir-92b Carcinoma, Non-Small-Cell Lung MiR-92b knockdown suppressed the NSCLC cells proliferation and migration in both in vivo and in vitro models. +genetics_overexpression_promote 32627648 hsa-mir-106a Nasopharyngeal Carcinoma MIR106A-5p overexpression in NPC was due to increased transactivation by EGR1 and SOX9. +epigenetics 32627576 hsa-mir-431 Intervertebral Disc Degeneration Conclusion:LOC102555094 might be demethylated by ZFP217, activating FTO and LOC102555094/miR-431/GSK-3beta/Wnt played a crucial role in IDD. +genetics_knock down_promote 32627519 hsa-mir-206 Osteosarcoma Overexpression of miRNA-206 accelerates osteosarcoma cells to proliferate and metastasize by targeting Notch3, thus accelerating the malignant progression of osteosarcoma. +lncRNA target 32627518 hsa-mir-10b Depression, Postpartum Taken together, these results revealed a novel mechanism of curcumin on PSD through the GAS5/miR-10b/BDNF regulatory axis. +other 32627107 hsa-mir-217 Diabetes Mellitus, Type 2 We attempt to explore the role of miR-217 during the process of type 2 diabetes mellitus (T2DM). The data from GEO database exhibited that miR-217 was upregulated in T2DM patients. +lncRNA target 32627090 hsa-mir-130a Ischemic Stroke In addition, MEG8 reduced cerebral ischemia, neurological score and miR-130a-5p expression, and increased VEGFA expression of MCAO rat. Our findings proved that MEG8 regulates angiogenesis and attenuates cerebral ischemia after ischemic stroke via miR-130a-5p/VEGFA signaling. +lncRNA target 32627090 hsa-mir-130a Brain Ischemia In addition, MEG8 reduced cerebral ischemia, neurological score and miR-130a-5p expression, and increased VEGFA expression of MCAO rat. Our findings proved that MEG8 regulates angiogenesis and attenuates cerebral ischemia after ischemic stroke via miR-130a-5p/VEGFA signaling. +genetics_overexpression_suppress 32627034 hsa-mir-675 Carcinoma, Hepatocellular miR675 inhibitor decreased the cell viability in sorafenibtreated HCC cells, while miR675 overexpression had the opposite effect on the treated cells. +lncRNA target 32627026 hsa-mir-433 Carcinoma, Non-Small-Cell Lung Finally, restoration experiments revealed that the suppression of miR4333p and restoration of Smad2 both counteracted the suppressive effects of OSER1AS1 depletion in NSCLC cells. +lncRNA target 32627018 hsa-mir-133b Atherosclerosis Taken together, miR133b aggravates AS by activating the Notch signaling pathway, which could serve as a potential target for the treatment of AS. +lncRNA target 32627014 hsa-mir-125a Ovarian Neoplasms In conclusion, these results suggested that propofol inhibited ovarian cancer proliferation and metastasis by enhancing miR125a5p, which targets LIN28B. +genetics_overexpression_promote 32626994 hsa-mir-196a Ovarian Neoplasms In the present study, it was demonstrated that overexpression of miR196a promoted ovarian cancer cell proliferation. +transcription factor target 32626991 hsa-mir-34a Retinoblastoma Collectively, the present results suggested that miR34a may negatively regulate Notch1 expression and may be a potential therapeutic target for RB. +other 32626985 hsa-mir-143 Ischemic Stroke The present study identified a number of transcription factors, including DEFA1, PDK4, SDPR, TCN1 and MMP9, and miRNAs, including miRNA (miR)21, miR143/145, miR1255p and miR122, which may serve important roles in the development of cerebral stroke and may be important molecular indicators for the treatment of IS. +other 32626985 hsa-mir-122 Ischemic Stroke The present study identified a number of transcription factors, including DEFA1, PDK4, SDPR, TCN1 and MMP9, and miRNAs, including miRNA (miR)21, miR143/145, miR1255p and miR122, which may serve important roles in the development of cerebral stroke and may be important molecular indicators for the treatment of IS. +other 32626985 hsa-mir-145 Ischemic Stroke The present study identified a number of transcription factors, including DEFA1, PDK4, SDPR, TCN1 and MMP9, and miRNAs, including miRNA (miR)21, miR143/145, miR1255p and miR122, which may serve important roles in the development of cerebral stroke and may be important molecular indicators for the treatment of IS. +transcription factor target 32626980 hsa-mir-195 Diabetes, Gestational It was identified that high mRNA expression of miR1955p, and low EZH2 mRNA and protein expression levels decreased the level of cell proliferation and the high apoptotic rate of GDMHUVECs. Therefore, the present results suggested that miR1955p may inhibit cell viability, proliferation and promote apoptosis by targeting EZH2 in GDMinduced HUVECs. +other 32626978 hsa-mir-122 Diabetes Mellitus Vascular complications are the primary reason for disability and mortality associated with diabetes mellitus (DM), and numerous microRNAs (miRNAs/miRs) are involved in the process, such as miR122, miR24 and miR423. +other 32626978 hsa-mir-28 Cardiovascular Diseases It has been reported that miR328 regulates DM and cardiovascular disease; however, the role and mechanism of action underlying miR328 in HUVECs is not completely understood. +other 32626978 hsa-mir-122 Vascular Diseases Vascular complications are the primary reason for disability and mortality associated with diabetes mellitus (DM), and numerous microRNAs (miRNAs/miRs) are involved in the process, such as miR122, miR24 and miR423. +other 32626978 hsa-mir-24 Diabetes Mellitus Vascular complications are the primary reason for disability and mortality associated with diabetes mellitus (DM), and numerous microRNAs (miRNAs/miRs) are involved in the process, such as miR122, miR24 and miR423. +other 32626978 hsa-mir-28 Diabetes Mellitus It has been reported that miR328 regulates DM and cardiovascular disease; however, the role and mechanism of action underlying miR328 in HUVECs is not completely understood. +other 32626978 hsa-mir-122 Pituitary Diseases Vascular complications are the primary reason for disability and mortality associated with diabetes mellitus (DM), and numerous microRNAs (miRNAs/miRs) are involved in the process, such as miR122, miR24 and miR423. +other 32626978 hsa-mir-24 Vascular Diseases Vascular complications are the primary reason for disability and mortality associated with diabetes mellitus (DM), and numerous microRNAs (miRNAs/miRs) are involved in the process, such as miR122, miR24 and miR423. +other 32626978 hsa-mir-423 Vascular Diseases Vascular complications are the primary reason for disability and mortality associated with diabetes mellitus (DM), and numerous microRNAs (miRNAs/miRs) are involved in the process, such as miR122, miR24 and miR423. +other 32626978 hsa-mir-423 Pituitary Diseases Vascular complications are the primary reason for disability and mortality associated with diabetes mellitus (DM), and numerous microRNAs (miRNAs/miRs) are involved in the process, such as miR122, miR24 and miR423. +other 32626978 hsa-mir-24 Pituitary Diseases Vascular complications are the primary reason for disability and mortality associated with diabetes mellitus (DM), and numerous microRNAs (miRNAs/miRs) are involved in the process, such as miR122, miR24 and miR423. +other 32626978 hsa-mir-423 Diabetes Mellitus Vascular complications are the primary reason for disability and mortality associated with diabetes mellitus (DM), and numerous microRNAs (miRNAs/miRs) are involved in the process, such as miR122, miR24 and miR423. +circulation_biomarker_diagnosis_up 32626976 hsa-mir-148b Neuroblastoma The results revealed significantly reversed expression levels of miR148b3p (P=0.0051) and ZNF804A (P=0.0218) in the peripheral blood of patients with firstonset schizophrenia compared with healthy individuals. +other 32626960 hsa-mir-185 Glioblastoma PAK7 may participate in the tumorigenesis of GBM by regulating axon guidance, and miR1855p may play an important role in GBM progression by sponging LINC00599 to prevent interactions with PAK7. +genetics_knock down_promote 32626959 hsa-mir-125a Alzheimer Disease Rescue experiments were conducted by transfecting lnc-ANRIL knockdown plasmid and lnc-ANRIL knockdown plasmid and miR-125a inhibitor in the PC12 cellular AD model as the KD-ANRIL group or KD-ANRIL KD-miR-125a group respectively. lnc-ANRIL knockdown suppressed cell apoptosis and inflammation while promoting neurite outgrowth via binding of miR-125a in AD. +genetics_GWAS 32626956 hsa-mir-192 Carcinoma, Non-Small-Cell Lung Notably, the genetic knockdown of miR1925p blocked the inhibitory effects of curcumin on NSCLC progression and instead promoted NSCLC progression, which was observed to be partially reversed by cMyc silencing; thus, cMyc was suggested to be a direct target gene of miR1925p as demonstrated by the TargetScanHuman database, duallucierase and RIP assay results. +genetics_overexpression_suppress 32626953 hsa-mir-146a Ovarian Neoplasms Subsequently, miR146a inhibitor or LAMC2 overexpression vectors were transfected into hUCMSCs or OC cells, respectively, and their effects on growth and chemoresistance in OC cells were assessed. +circulation_biomarker_diagnosis_up 32626951 hsa-mir-27a Pancreatic Carcinoma Following the transfection of DGCR5 plasmid into PaCa cells, the expression of miR27a3p was downregulated, and this downregulation was reversed following transfection with miR27a3p mimic. +other 32626949 hsa-mir-467a Learning Disabilities The most represented pathways for miRNAs included 'neuroactive ligandreceptor interaction' (miR1187), 'longterm depression' (miR4255p), 'FoxO signaling pathway' (miR4255p) and the 'neurotrophin signaling pathway' (miR467a3p). +other 32626949 hsa-mir-1187 Learning Disabilities The most represented pathways for miRNAs included 'neuroactive ligandreceptor interaction' (miR1187), 'longterm depression' (miR4255p), 'FoxO signaling pathway' (miR4255p) and the 'neurotrophin signaling pathway' (miR467a3p). +other 32626949 hsa-mir-425 Learning Disabilities The most represented pathways for miRNAs included 'neuroactive ligandreceptor interaction' (miR1187), 'longterm depression' (miR4255p), 'FoxO signaling pathway' (miR4255p) and the 'neurotrophin signaling pathway' (miR467a3p). +lncRNA target 32626945 hsa-mir-200c Osteochondrodysplasias These results revealed the role of miR200c3p in HTM cells and its underlying molecular mechanism, which may provide a potential target for the treatment of patients with glaucoma. +transcription factor target 32626945 hsa-mir-200c Glaucoma These results revealed the role of miR200c3p in HTM cells and its underlying molecular mechanism, which may provide a potential target for the treatment of patients with glaucoma. +lncRNA target 32626943 hsa-mir-375 Liver Neoplasms The MALAT1/miR375/YAP1 axis may serve as a novel target for liver cancer therapy, particularly for the eradication of liver CSCs. +other 32626939 hsa-mir-1236 Carcinoma, Squamous Cell, Cutaneous In conclusion, the results of the present study demonstrated the effects of the circ0070934/miR12363p/HOXB7 regulatory axis on CSCC and provided a novel insight for the pathogenesis of CSCC. +other 32626937 hsa-mir-142 Arteriosclerosis However, whether miR1425p is involved in regulating the pathological process of arteriosclerosis remains to be elucidated. +circulation_biomarker_diagnosis_down 32626937 hsa-mir-142 Angelman Syndrome Moreover, there was a negative correlation between miR1425p and MKL2 expression in the serum of patients with AS. +circulation_biomarker_diagnosis_down 32626936 hsa-mir-195 Angelman Syndrome The expression levels of miR1955p and CTBP1AS2 in the serums of patients with AS and human aorta vascular smooth muscle cells was increased or decreased, respectively, following treatment with oxidized lowdensity lipoprotein (oxLDL). +genetics_overexpression_promote 32626930 hsa-mir-92a Carcinoma, Non-Small-Cell Lung Moreover, the tumorsuppressive effects of CASC7 were partly reversed by miR92a overexpression in NSCLC cells. +transcription factor target 32626928 hsa-mir-137 Prostatic Neoplasms PC3 and DU145 prostate cancer cells were exposed to hypoxia for 24 h, after which the expression of miR137 was determined by reverse transcriptionquantitative PCR (RTqPCR). In conclusion, by targeting LGR4 via the EGFR/ERK signaling pathway, miR137 inhibited prostate cancer cell migration and EMT. +genetics_knock down_promote 32626925 hsa-mir-144 Squamous Cell Carcinoma of Head and Neck Notably, EZH2 knockdown inhibited cell proliferation, promoted cell apoptosis, and suppressed the invasion and migration of OSCC cells, whereas EZH2 overexpression partially reversed the anticancer effects mediated by miR1443p overexpression. +transcription factor target 32626917 hsa-mir-1 Osteoarthritis On the whole, the findings of the present study demonstrate that miR1 expression protects against osteoarthritisinduced cartilage damage and gene expression by inhibiting Ihh signaling. +other 32626916 hsa-mir-199a Alzheimer Disease On the whole, the data of the present study suggest that miR199a is involved in the development of AD by regulating Neuritin expression. +lncRNA target 32626915 hsa-mir-383 Stomach Neoplasms Transfectoin with miR3835p mimic significantly inhibited GC cell proliferation, while it promoted cell apoptosis and G0/G1 arrest by targeting CIP2A. +other 32626913 hsa-mir-128 Diabetes Mellitus In addition, AIV significantly decreased the apoptotic levels of RPE cells from rats with DM and significantly decreased the protein expression levels of Bax/Bcl2, Fas/FasL, active caspase3, active caspase8, active caspase9, homeobox B3 (HOXB3), pphosphoinositide 3kinase (PI3K)/PI3K, pAKT/AKT and pp70S6K1/p70S6K1, whereas it significantly increased miR128 expression in the RPE cells from rats with DM. On the whole, the findings of the present study demonstrate that AIV treatment protects RPE cells of diabetic rats from apoptosis, and that these effects may be associated with the upregulation of miR128 expression. +lncRNA target 32626910 hsa-mir-16 Moebius syndrome 1 Collectively, these results demonstrated that miR16 may suppress Ems by inhibiting the IKKbeta/NFkappaB pathway, suggesting that miR16 may be a useful target in the treatment of Ems. +circRNA target 32626774 hsa-mir-519a Fetal Macrosomia These findings improve our understanding of the mechanisms of progression of fetal macrosomia and will guide future development of therapeutic strategies against the disease by targeting the circ-SETD2/miR-519a/PTEN axis. +transcription factor target 32626771 hsa-mir-714 Macular Degeneration Moreover, miRFDFT1 may modulate cholesterol homeostasis in aged macrophages and have the potential to be a novel therapeutic target for AMD. +lncRNA target 32626753 hsa-mir-545 Stomach Neoplasms Methods The expression of SBF2-AS1 and miR-545 were examined in GC tissues and cell lines via real-time quantitative PCR. Conclusion These findings elucidated a crucial role of SBF2-AS1 as a miR-545 sponge in GC cells, suggesting that SBF2-AS1 might be a potential target for GC. +genetics_overexpression_promote 32626749 hsa-mir-21 Cholangiocarcinoma To support, overexpression of miR-21 blocks galangin-mediated antisurvival and metastasis effects on CCA cells. +circulation_biomarker_diagnosis_ns 32626740 hsa-mir-100 Pregnancy, Ectopic CONCLUSIONS: Although further validation in large-scale prospective studies is necessary, our results suggest that serum exosomal miR-378d, miR +circulation_biomarker_diagnosis_ns 32626740 hsa-mir-215 Pregnancy, Ectopic CONCLUSIONS: Although further validation in large-scale prospective studies is necessary, our results suggest that serum exosomal miR-378d, miR +other 32626660 hsa-mir-6833 Colorectal Neoplasms 3P were negatively correlated with circ-PNN in CRC patients. +other 32626660 hsa-mir-1301 Colorectal Neoplasms 3P were negatively correlated with circ-PNN in CRC patients. +other 32626660 hsa-let-7i Colorectal Neoplasms 3P were negatively correlated with circ-PNN in CRC patients. +lncRNA target 32626571 hsa-let-7 Carcinoma, Hepatocellular In further experiments, we found that let-7b inhibited HCC cell proliferation through upregulation of p21. +lncRNA target 32626571 hsa-let-7b Carcinoma, Hepatocellular In further experiments, we found that let-7b inhibited HCC cell proliferation through upregulation of p21. +circulation_biomarker_diagnosis_down 32626537 hsa-mir-139 Colorectal Neoplasms 3p expression levels in CRC patient plasma may act as a novel biomarker for the early diagnosis and metastasis monitoring in CRC. +lncRNA target 32626530 hsa-mir-1 Colorectal Neoplasms Conclusion: miR-1 enhanced the radiosensitivity of CRC cells by inducing cell apoptosis and the synergic inhibition of aggressive phenotypes, which may serve as a promising therapeutic target for CRC patients. +genetics_GWAS 32626527 hsa-mir-548a Carcinoma, Non-Small-Cell Lung Upregulation of NEIL2 expression or downregulation of miR-548a could reduce the sensitivity of NSCLC cells to cisplatin. Conclusion: Our results demonstrated that NEIL2 gene rs8191670 polymorphism affects the PFS of advanced NSCLC patients, and the underlying molecular mechanisms may be that miR-548a can regulate NEIL2 expression by binding to its 3'UTR seed region containing rs8191670. +target gene 32626524 hsa-mir-675 Pancreatic Neoplasms LncRNA H19-Derived miR-675-3p Promotes Epithelial-Mesenchymal Transition and Stemness in Human Pancreatic Cancer Cells by targeting the STAT3 Pathway. +target gene 32626523 hsa-mir-532 Lymphoma miR-532-3p Inhibits Proliferation and Promotes Apoptosis of Lymphoma Cells by Targeting β-Catenin. +exosome 32626519 hsa-mir-410 Colorectal Neoplasms Exosomes Derived from Hypoxic Colorectal Cancer Cells Transfer miR-410-3p to Regulate Tumor Progression. +exosome 32625049 hsa-mir-29 Alzheimer Disease The expression of miR-29 family is significantly reduced in AD, suggesting a part for the family members in pathogenesis of the disease. In conclusion, our findings provide a new approach for the packaging of miR-29 in exosomes and that the engineered exosomes might have a therapeutic potential in AD. +genetics_knock down_suppress 32624708 hsa-mir-15a Prostatic Neoplasms RESULTS: The expression of PVT1 and KIF23 was enhanced, while miR-15a-5p expression was reduced in PCa tissues and cells. CONCLUSION: PVT1 knockdown had effects on the progression of PCa by inhibiting the expression of KIF23 via enriching miR-15a-5p in vitro and in vivo, suggesting that PVT1 might be a novel biomarker for the treatment of PCa. +circulation_biomarker_diagnosis_ns 32624699 hsa-mir-222 Adenocarcinoma of Lung Here, we obtained circulating exosomal miRNA repertoires of 7 early-stage lung adenocarcinoma patients including pre-operation and post-operation (LA-pre and LA-post) and 7 heathy controls (HCs) by next generation sequence (NGS) and selected miR +circulation_biomarker_diagnosis_ns 32624699 hsa-mir-574 Adenocarcinoma of Lung In summary, circulating exosomal miR +circulation_biomarker_diagnosis_ns 32624699 hsa-mir-342 Adenocarcinoma of Lung In summary, circulating exosomal miR +other 32624698 hsa-mir-25 Heart Injuries Our study aimed to investigate the relationship between miR-25 and DOX-induced cardiac injury and its underlying mechanism. +lncRNA target 32624692 hsa-mir-149 Liver Neoplasms Consequently, our results demonstrated that depletion of circRNA_10156 upregulated miR3p, reduced Akt1 expression, and suppressed liver cancer cell proliferation. +transcription factor target 32623835 hsa-mir-155 Breast Neoplasms Schizandrin A inhibits cellular phenotypes of breast cancer cells by repressing miR-155. CONCLUSION Taken together, SchA downregulates miR-155 and results in the suppression of proliferation and motility in breast cancer cells. +transcription factor target 32623445 hsa-mir-143 Esophageal Squamous Cell Carcinoma 5p regulation, and one gene (KRT80) was a putative target of miR +lncRNA target 32623387 hsa-mir-21 Adenocarcinoma of Lung 5p facilitates LUAD cell proliferation, migration and invasion through targeting WWC2, which provides a novel therapeutic target for LUAD treatment. +lncRNA target 32623385 hsa-let-7f Urinary Bladder Neoplasms CONCLUSIONS: We have identified Let-7f-5p as a miRNA biomarker of recurrence in NMIBC tumors. We further demonstrate that targeting Lin28, a negative regulator of Let-7f-5p, represents a novel potential therapeutic opportunity in NMIBC. +other 32623093 hsa-mir-319 Dehydration We further validated the reference genes by expression analysis of the well-characterized miR319 and miR156 that regulate drought and salt stress responses, respectively. +other 32623093 hsa-mir-156 Dehydration We further validated the reference genes by expression analysis of the well-characterized miR319 and miR156 that regulate drought and salt stress responses, respectively. +lncRNA target 32622721 hsa-mir-125b bladder urothelial carcinoma Hsa-miR-125b is a target for TINCR in UCB. +exosome 32622528 hsa-mir-194 polycystic kidney disease 3 5p and two potentially relevant candidate genes, PIK3R1 and ANO1. +exosome 32622528 hsa-mir-192 polycystic kidney disease 3 5p, miR-30a-5p, miR-30d-5p and miR-30e-5p were significantly downregulated in patient urine exosomes, in murine Pkd1 cystic kidneys and in human PKD1 cystic kidney tissue. +genetics_knock down_promote 32622332 hsa-mir-20b Esophageal Squamous Cell Carcinoma An analysis of the methylation status of the miR-20b-5p gene indicated that the hypomethylation of the CpG sites located upstream of the miR-20b-5p gene in the ESCC tissues was more frequent than in the adjacent normal tissues, and the methylation status of miR-20b-5p correlated inversely with its expression levels. Notably, a series of gain- and loss-of-function assays elucidated that miR-20b-5p promoted ESCC cell proliferation, migration, and invasion both in vitro and in vivo. +genetics_overexpression_promote 32622330 hsa-mir-34a Triple Negative Breast Neoplasms In this study, we introduce an alternative treatment strategy for TNBC that exploits its overexpression of Notch1 receptors and its underexpression of the tumor suppressive microRNA (miRNA) miR-34a. +genetics_overexpression_suppress 32622014 hsa-mir-487a Pancreatic Carcinoma Overexpression of SMAD7 reversed the regulatory effects of miR-487a-3p on pancreatic cancer cell phenotypes. +other 32622013 hsa-mir-129 Stomach Neoplasms 5p/P4HA2 axis was confirmed to possess a crucial role in GC metastasis and invasion, suggesting its utility as a potential diagnostic and therapeutic biomarker. +other 32622012 hsa-mir-199a Diabetic Retinopathy This research aims to confirm the roles of miRNA-199a-3p in the progression of angiogenesis in an in vitro model of DR. +circRNA target 32621951 hsa-mir-140 Endometriosis Decrease of circ_0061140 could depress endometriosis progression through modulating miR +genetics_overexpression_promote 32621752 hsa-mir-181a Ovarian Neoplasms, High-Grade Serous and TCGA external cohorts further confirmed the unfavorable prognostic nature of miR-181a overexpression in SOC. +genetics_knock down_promote 32621625 hsa-mir-455 Osteosarcoma Knockdown of lncRNA LINC00319/NFIB or overexpression of miR +genetics_overexpression_promote 32621118 hsa-mir-384 Hypoxia-Ischemia, Brain, Newborn The OGD-induced increase in microglial neuroinflammation was significantly attenuated by the overexpression of miR-384, and AKT3, as a downstream target of miR-384, was inhibited by miR-384 in activated microglia. +lncRNA target 32621115 hsa-mir-204 Medulloblastoma We have earlier reported that the tumor-suppressive role of miR-204 and miR-30a is accompanied by inhibition of autophagy in medulloblastoma cells. +lncRNA target 32621101 hsa-mir-30 Cancer Pain These results show that miR-330 participates in the genesis of pancreatic carcinoma-induced pain hypersensitivity by inhibiting GABA(B)R2 expression in the SDH and might be a potential therapeutic target for pancreatic cancer pain. +other 32620748 hsa-mir-1976 Triple Negative Breast Neoplasms MiR-1976 was found to be downregulated in TNBC tissues, and lower expression of miR-1976 was correlated with worse overall survival in a patient cohort obtained from TCGA database. +lncRNA target 32620711 hsa-mir-152 Diabetes Mellitus 3p inhibition may effectively accelerate wound repair, thereby providing a potential target for DFU therapy. +other 32620696 hsa-mir-206 Muscular Dystrophies We found that miR-206 expression increases in both physiological (including female sex and endurance exercise) and pathological conditions (muscular dystrophy and adrenergic agonism) that promote a slow phenotype. +other 32620610 hsa-mir-1 Colorectal Neoplasms 5p) showed significant (FDR<0.05) up-regulation in right-sided CRC. +other 32620610 hsa-mir-196b Colorectal Neoplasms One of these (hsa-miR-196b-5p) was significantly (FDR<0.05) up-regulated in left-sided CRC. +other 32620610 hsa-mir-155 Colorectal Neoplasms 5p) showed significant (FDR<0.05) up-regulation in right-sided CRC. +other 32620610 hsa-mir-625 Colorectal Neoplasms 5p) showed significant (FDR<0.05) up-regulation in right-sided CRC. +other 32620610 hsa-mir-30 Colorectal Neoplasms 5p) showed significant (FDR<0.05) up-regulation in right-sided CRC. +other 32620145 hsa-mir-4319 Osteosarcoma We uncovered the important contribution of LINC00426/miR-4319 to Dox resistance in osteosarcoma. +exosome 32620067 hsa-mir-4450 Intervertebral Disc Degeneration hPLMSC-derived exosomes could be a feasible nanovehicle to deliver inhibitory oligonucleotides like AntagomiR-4450 in IDD. +lncRNA target 32619931 hsa-mir-483 Myocardial Reperfusion Injury 3p may be a potential therapeutic target of myocardial IR injury. +genetics_knock down_suppress 32619670 hsa-mir-21 Hypoxia-Ischemia, Brain Knockdown analyses revealed that miR-21a-5p, and its target-Timp3, were essential for this neuroprotective property of MSC-EVs following HI exposure as demonstrated in both in vitro and in vivo models. +transcription factor target 32619668 hsa-mir-1184 Colonic Neoplasms In conclusion, over-expression of miR-1184 inhibits colon cancer cell proliferation but promotes their apoptosis through down-regulating CSNK2A1 expression. +genetics_GWAS 32619376 hsa-mir-17 Fluorosis, Dental OBJECTIVES The aim of this study is to evaluate the association between the single nucleotide polymorphism (SNP) rs4284505 within the gene that codifies microRNA17 (miRNA17) and dental fluorosis (DF) in a group of children. CONCLUSION The miR-SNP rs4284505 in miRNA17 was associated with an increased risk of DF. +lncRNA target 32619135 hsa-mir-216a Lung Neoplasms MiR-216a-3p regulated proliferation, apoptosis, migration, and invasion of lung cancer cells via targeting COPB2. +genetics_overexpression_promote 32619071 hsa-mir-134 Multiple Sclerosis Collectively, overexpression of miR +genetics_overexpression_promote 32619070 hsa-mir-1287 Colorectal Neoplasms Rescue assays in vitro and in vivo showed that overexpression of YBX1 could partly offset the effect of CRC progression induced by knocking down PRKCQ-AS1, demonstrating PRKCQ-AS1 mediating CRC progression via miR +lncRNA target 32619044 hsa-mir-122 Osteoporosis By means of miRanda algorithm, we constructed the interaction network of circ_0011269-miRNAs in osteoporosis based on target binding and miR-122 was enrolled in the network. In summary, this study found that circ_0011269 sponges miR-122 to regulate RUNX2 expression and promotes osteoporosis progression. +circulation_biomarker_diagnosis_ns 32618342 hsa-mir-96 Neonatal Sepsis 5p was low expressed while nicotinamide phosphoribosyltransferase (NAMPT) was high expressed in the serum of neonatal septicemia patients. +exosome 32618144 hsa-mir-204 Colorectal Neoplasms CCK-8 and colony formation assays showed that the cell proliferation ability of CRC cells was clearly inhibited by 293T-miR-204 cell-derived CM or exosomes. +lncRNA target 32617870 hsa-mir-143 Carcinoma, Hepatocellular CONCLUSION: Inhibiting FGF1 can upregulate miR +lncRNA target 32617074 hsa-mir-135a Pulmonary Fibrosis The collective data indicate miR-135a restrains NF-kappaB activation probably through targeting TLR4 to alleviate silica-induced inflammatory response and pulmonary fibrosis. +other 32617074 hsa-mir-135a Lung Diseases But the roles of miRNA135a involved in the silica-induced lung damages remain largely unexplored. +lncRNA target 32617074 hsa-mir-135a Inflammation miR-135a inhibits inflammation, apoptosis, and cancer cell proliferation. Injection of PDTC, an inhibitor of NF-kappaB, further reinforced miR-135a-mediated amelioration of inflammation and pulmonary fibrosis induced by silica. +lncRNA target 32616906 hsa-mir-375 Carcinoma, Hepatocellular First, we identified that the expression of the tumor-suppressive miRNA miR-375 was significantly induced in hepatoma cells treated with sorafenib, and miR-375 could exert its antiangiogenic effect partially via platelet-derived growth factor C (PDGFC) inhibition. +transcription factor target 32616510 hsa-mir-3150b Uterine Cervical Neoplasms In conclusion, our data suggested that miR-3150b-3p directly targets TNFRSF11a to inactivate the p38 MAPK signaling pathway, thus implicating miR-3150b-3p in the regulation of CC cell growth. +transcription factor target 32616068 hsa-mir-519d Myocardial Infarction CONCLUSION: Our findings indicate that nonadherent culture-induced secretion of VEGFA plays an important role in MSCs via the miR-519d/VEGFA pathway and may provide a novel therapeutic strategy for MI treatment. +other 32615958 hsa-mir-584 Stomach Neoplasms These findings suggest the potential of miR-584 as a diagnostic or prognostic biomarker in gastric cancer. +other 32615692 hsa-mir-378 Diabetes Mellitus, Type 1 CONCLUSION: Elevated miRNA-378 expression in T1D patients compared with controls is linked to pubertal stage but is not associated with proinflammatory status or body composition. +genetics_knock down_promote 32615662 hsa-mir-223 Asthma 3p in peripheral blood leukocytes was upregulated in the asthmatic patients compared with that in the healthy controls. +target gene 32615527 hsa-mir-4500 Breast Neoplasms MicroRNA-4500 Inhibits Migration, Invasion, and Angiogenesis of Breast Cancer Cells via RRM2-Dependent MAPK Signaling Pathway. +other 32615059 hsa-mir-520c Testicular Germ Cell Tumor 3p), five hub TFs (ETS1, HIF1A, HNF1A, MYC, and SP1), and three hub genes (CDH1, CXCR4, and SNAI1) in the SE-specific regulatory network. +other 32615059 hsa-mir-520b Testicular Germ Cell Tumor 3p), five hub TFs (ETS1, HIF1A, HNF1A, MYC, and SP1), and three hub genes (CDH1, CXCR4, and SNAI1) in the SE-specific regulatory network. +other 32615025 hsa-mir-155 Graft vs Host Disease Patients with GD due to TCMR (n = 21) exhibited significantly higher (P < 0.001) expression of miRNA 155-5p (2.05 versus 0.07), 122-5p (19.36 versus 1.66), and 181a-5p (1.33 versus 0.37) compared with those with GD from other causes (n = 28). +genetics_knock down_suppress 32614902 hsa-mir-511 Zika Virus Infection Here, we demonstrate that interstitial leukocytes expressing mir +genetics_GWAS 32614806 hsa-mir-155 Maxillary Sinusitis RESULTS Results showed that the expression level of NF-kappaB/miR-155 was significantly elevated in the Eos CRSwNP group, accompanied by the upregulation of cytokines: tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, IL-4, IL-5 (P<0.05) compared with the control group, the CRSsNP group or the Non-Eos CRSwNP group. +genetics_GWAS 32614806 hsa-mir-155 Nasal Polyps RESULTS Results showed that the expression level of NF-kappaB/miR-155 was significantly elevated in the Eos CRSwNP group, accompanied by the upregulation of cytokines: tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, IL-4, IL-5 (P<0.05) compared with the control group, the CRSsNP group or the Non-Eos CRSwNP group. +other 32614785 hsa-mir-145 Carcinoma, Non-Small-Cell Lung Collectively, circMET regulates the miR5p/CXCL3 axis and serves as a novel, promising diagnostic and prognostic biomarker in patients with NSCLC. +genetics_knock down_promote 32614615 hsa-mir-519d Stomach Neoplasms Furthermore, ROR knockdown downregulated HMGA2 to restrain cell proliferation, migration, invasion, epithelial-mesenchymal transition (EMT), and cisplatin resistance in GC cells by targeting miR-519d-3p. +circRNA target 32614609 hsa-mir-21 Carcinoma, Non-Small-Cell Lung Conclusions: Circ-LARP4 is decreased and suppresses cell proliferation while promoted apoptosis by sponging miR5p in NSCLC. +lncRNA target 32614608 hsa-mir-125b lung squamous cell carcinoma A tumor-suppressive role of miR-125b-5p is proposed, based on its effects on LUSC tumor growth, clinical stage progression, and lymph node metastasis. +transcription factor target 32614381 hsa-mir-155 Carcinoma, Ovarian Epithelial Increased expression of miR-155 was also detected in primary HGSOC tumors compared with benign primary human FTE and corresponded with changes in the expression of miR-155 target genes. +genetics_overexpression_promote 32614357 hsa-mir-145 Tuberculosis The overexpression of miR-145 in macrophages upon Mtb infection can suppress cell viability and infection-induced inflammation via regulating CXCL16, indicating the potential of miR-145 as a therapeutic target of TB. +other 32614269 hsa-mir-188 Infertility, Male 3p) which had shown differential expression in male infertility in other studies, and also had differential expression in smoking men compared to non-smokers, were screened out. +other 32614269 hsa-mir-512 Infertility, Male 3p) which had shown differential expression in male infertility in other studies, and also had differential expression in smoking men compared to non-smokers, were screened out. +other 32614269 hsa-mir-26a Infertility, Male 3p) which had shown differential expression in male infertility in other studies, and also had differential expression in smoking men compared to non-smokers, were screened out. +other 32614269 hsa-mir-2 Infertility, Male 3p) which had shown differential expression in male infertility in other studies, and also had differential expression in smoking men compared to non-smokers, were screened out. +circulation_biomarker_diagnosis_ns 32614237 hsa-mir-125a Prostatic Neoplasms 3p and low expression of miR-125a-5p in plasma exosomes from prostate cancer patients might be useful markers of specific tumor traits associated with prostate cancer. +circulation_biomarker_diagnosis_ns 32614237 hsa-mir-141 Prostatic Neoplasms 3p and low expression of miR-125a-5p in plasma exosomes from prostate cancer patients might be useful markers of specific tumor traits associated with prostate cancer. +lncRNA target 32614236 hsa-mir-377 Neuroblastoma 3p, which was downregulated in neuroblastomas and inhibited cell proliferation and invasion. +lncRNA target 32613573 hsa-mir-597 Pancreatic Carcinoma 5p decreased pancreatic cancer cell viability, reduced relative wound width, suppressed colony formation and decreased invasive cell number, as well as reduced the expression of proliferating cell nuclear antigen (PCNA), Ki67, Cyclin D1, N-cad, and Bcl-2. +lncRNA target 32613482 hsa-mir-543 Glioma SNHG6 served as an oncogene and played a vital role in glioma development through miR-543/LMO3 axis. +genetics_overexpression_promote 32613412 hsa-mir-144 Stomach Neoplasms 3p overexpression or silencing ZEB1 dramatically inhibited the proliferation activity of GC cells under 6 Gy radiation, increased the levels of pro-apoptotic Bax and caspase-3 proteins (p < 0.05) and decreased the anti-apoptotic protein Bcl-2 level (p < 0.05), resulting in an increase in the apoptosis rate of cells. +other 32613197 hsa-mir-206 Amyotrophic Lateral Sclerosis Furthermore, hsa-miR-206, a previously identified amyotrophic lateral sclerosis biomarker, showed a binary-like pattern of expression in our samples. +lncRNA target 32612946 hsa-mir-193a Colorectal Neoplasms In conclusion, this finding indicates that circCSPP1 may act as a promising therapeutic target by regulating the EMT process in colorectal carcinoma via activation of the circCSPP1/miR-193a-5p/COL1A1 axis. +other 32612537 hsa-mir-132 Coronary Artery Disease Conclusion: Although we previously observed a role in collateral formation and myocardial contractility, the absence of miR-132/212 did not affect the overall myocardial performance upon a permanent occlusion of the coronary artery. +lncRNA target 32612387 hsa-mir-34a Lymphoma, Large B-Cell, Diffuse Immunotherapies targeting PD-L1 and miR-34a pathway may have therapeutic potential in GDLBCL. +transcription factor target 32612385 hsa-mir-181a esophagus adenocarcinoma CONCLUSION: miR-181a-5p enhanced the sensitivity of cells to cisplatin in EAC by targeting CBLB, indicating a promising sensitizer of cisplatin therapy in clinical esophageal cancer. +lncRNA target 32612368 hsa-mir-512 Carcinoma, Hepatocellular 3p contributes to HCC cell proliferation, migration, and invasion by targeting LATS2 and inhibiting the Hippo/yes-associated protein 1 pathways. +lncRNA target 32612287 hsa-mir-126 Aortic Aneurysm, Abdominal 5p in inhibiting AAA development-associated aortic SMC dedifferentiation. +other 32612164 hsa-mir-23a Prostatic Neoplasms We previously identified the four-miRNA prognostic biomarker panel MiCaP ((miR-23a-3p x miR-10b-5p)/(miR-133a-3p x miR-374b-5p)) for prediction of biochemical recurrence (BCR) after radical prostatectomy (RP). +other 32612164 hsa-mir-374b Prostatic Neoplasms We previously identified the four-miRNA prognostic biomarker panel MiCaP ((miR-23a-3p x miR-10b-5p)/(miR-133a-3p x miR-374b-5p)) for prediction of biochemical recurrence (BCR) after radical prostatectomy (RP). +other 32612164 hsa-mir-133a Prostatic Neoplasms We previously identified the four-miRNA prognostic biomarker panel MiCaP ((miR-23a-3p x miR-10b-5p)/(miR-133a-3p x miR-374b-5p)) for prediction of biochemical recurrence (BCR) after radical prostatectomy (RP). +other 32612164 hsa-mir-10b Prostatic Neoplasms We previously identified the four-miRNA prognostic biomarker panel MiCaP ((miR-23a-3p x miR-10b-5p)/(miR-133a-3p x miR-374b-5p)) for prediction of biochemical recurrence (BCR) after radical prostatectomy (RP). +lncRNA target 32612026 hsa-mir-106b Aortic Aneurysm, Abdominal CONCLUSIONS: We identified that SNHG16/miR-106b-5p/STAT3 formed a complex circuitry for the deterioration of AAA via regulating VSMCs, suggesting a possible target for the pathogenesis of AAA. +genetics_overexpression_promote 32611832 hsa-mir-124 Atherosclerosis MiR-124 overexpression may be a promising treatment for atherosclerosis and CAD via inhibiting p38. +transcription factor target 32611384 hsa-mir-10a Kidney Diseases Injection of miR-10a agonist significantly aggravated the renal injury and raised the level of cell apoptosis in the renal tissues of I/R-injured rats (p < 0.05). However, administration of miR-10a antagonist led to obvious improvement of the renal injury, decreased renal cell apoptosis, and inhibited PI3K/Akt pathway activity (p < 0.05). +transcription factor target 32611384 hsa-mir-10 Kidney Diseases Injection of miR-10a agonist significantly aggravated the renal injury and raised the level of cell apoptosis in the renal tissues of I/R-injured rats (p < 0.05). However, administration of miR-10a antagonist led to obvious improvement of the renal injury, decreased renal cell apoptosis, and inhibited PI3K/Akt pathway activity (p < 0.05). +other 32611384 hsa-mir-10 Reperfusion Injury BACKGROUND: To investigate the effect of miR-10a on renal tissues with ischemia reperfusion (I/R) injury in rats and to explore the underlying mechanisms of the effect of miR-10a on hypoxia-reoxygenation in HK-2 cells. +other 32611384 hsa-mir-10a Reperfusion Injury BACKGROUND: To investigate the effect of miR-10a on renal tissues with ischemia reperfusion (I/R) injury in rats and to explore the underlying mechanisms of the effect of miR-10a on hypoxia-reoxygenation in HK-2 cells. +genetics_overexpression_promote 32611384 hsa-mir-10a familial febrile seizures 1 Furthermore, overexpression of miR-10a significantly decreased the proliferation of HK-2 cells, and increased cell apoptosis via up-regulation of the PI3K/Akt pathway (p < 0.05). +genetics_overexpression_promote 32611384 hsa-mir-10 familial febrile seizures 1 Furthermore, overexpression of miR-10a significantly decreased the proliferation of HK-2 cells, and increased cell apoptosis via up-regulation of the PI3K/Akt pathway (p < 0.05). +circulation_biomarker_diagnosis_ns 32611374 hsa-mir-200 Carcinoma, Ovarian Epithelial The miRNA-200 family has been shown to be dysregulated in ovarian cancer. The aim of this study was to isolate three members of miR-200 family from tumor tissue, plasma and urine of high-grade serous ovarian cancer patients in comparison with samples from patients with benign ovarian tumors. +target gene 32610610 hsa-mir-675 Breast Neoplasms H19 and miR-675 could enhance the aggressiveness of breast cancer cells through both common and different mechanisms. +lncRNA target 32610494 hsa-mir-34a Head and Neck Neoplasms Our findings proved that genistein induced ROS production through upregulation of miR-34a, leading to apoptosis in HNC-TICs. These results suggested that genistein-induced miR-34a contributed to the ROS-associated apoptosis and diminished stemness properties via repression of RTCB in HNC-TICs. +circulation_biomarker_diagnosis_up 32610326 hsa-mir-3162 Asthma 3p in the peripheral blood of children with asthma was obviously upregulated compared to that in healthy children. +other 32610163 hsa-mir-21 Poikiloderma with Neutropenia 5p, apoptosis, and autophagy promotes us to find a new mechanism to improve the treatment for PNP. +other 32610163 hsa-mir-21 Peripheral Nervous System Diseases 5p) in the oxidative stress-induced apoptosis of Schwann cells and the relevant mechanism in this research, laying a foundation for the treatment of peripheral neuropathy (PNP). +transcription factor target 32610139 hsa-mir-137 Memory Disorders We conclude that the ablation of ATRX in excitatory forebrain neurons leads to sexually dimorphic effects on miR-137 expression and on spatial memory, identifying a potential therapeutic target for neurological defects caused by ATRX dysfunction. +other 32610100 hsa-mir-143 Neuropathic Lysosomal Storage Diseases "These studies not only uncover a novel role of miR-143 as an important modulator for the developmental decline of CI-MPR on the BBB, but they also demonstrate the functional significance of depleting miR-143 for ""rescuing"" BBB-anchored CI-MPR on advancing CNS treatment for nLSDs." +genetics_knock down_promote 32609900 hsa-mir-125b Carcinoma, Hepatocellular CONCLUSIONS: MiR-125b loss activated the HIF1alpha/pAKT loop, contributing to HCC resistance to TACE and the key nodes in this axis hold the potential in assisting patients with HCC to choose TACE therapy. +lncRNA target 32609259 hsa-mir-217 Leukemia, Myeloid, Acute Moreover, LINC01268 positively regulated SOS1 expression to promote AML cell viability and cell cycle progression but inhibited apoptosis via sponging miR-217. LINC01268 promoted cell growth and inhibited cell apoptosis through modulating miR-217/SOS1 axis in AML. +genetics_overexpression_promote 32608996 hsa-mir-590 Arthritis, Rheumatoid 5p reversed the effect of linc02381 overexpression on MAP2K3 expression. +other 32608553 hsa-mir-100 Stomach Neoplasms Clinical samples showed patients with higher MIR100HG expression had poorer prognosis, and further experiments demonstrated that MIR100HG was associated with proliferation, migration and invasion of GC cells. Hopefully, MIR100HG might be considered as a novel prognostic factor and biomarker for GC. +other 32608537 hsa-mir-125a Multiple Myeloma CONCLUSION: lncRNA NEAT1 might interact with miR-125a, and serves as a novel biomarker for treatment response and survival profiles in MM, indicating its clinical value for MM management. +lncRNA target 32608284 hsa-mir-20a Diabetic Nephropathies Our findings showed that miR-20a might be a significant regulator of HG-induced renal proximal tubular inflammatory injury mediating diabetic kidney disease through regulation of the expression of CXCL8 and the MEK/ERK pathway. +genetics_overexpression_promote 32608213 hsa-mir-369 Carcinoma, Hepatocellular 3p overexpression inhibited cell viability and motility in HCC. +genetics_knock down_promote 32607966 hsa-mir-656 Carcinoma, Hepatocellular 3p or knockdown of SIRT5 significantly suppressed the biological process of HepG2 and MHCC97H cells. +other 32607693 hsa-mir-124a Crohn Disease This study suggests that miR-124a can induce intestinal inflammation and cause intestinal barrier dysfunction by supressing AHR. +other 32607676 hsa-mir-218 Astrocytoma In this study, for the first time, we aimed to analyze the possible effect of the sialic acid solution exposure in the human C118 cell line, which was derived from a human brain astrocytoma (glial cells), on the expression patterns of miR-218, NF-kB, MMP-9, and TIMP-1. +genetics_overexpression_promote 32607060 hsa-mir-1269a Lung Neoplasms CONCLUSIONS: Down-regulation of LINC00261 expression has a prognostic value in LC, and overexpression LINC00261 inhibits LC progression via targeting miR-1269a/FOXO1 axis. +other 32606978 hsa-mir-140 Colorectal Neoplasms CircRNA SMARCC1 Sponges MiR-140-3p to Regulate Cell Progression in Colorectal Cancer. +other 32606970 hsa-mir-26a Uterine Cervical Neoplasms 3p were found to be sponged by circRNA_101308 in CC cells. +other 32606970 hsa-mir-196a Uterine Cervical Neoplasms 3p were found to be sponged by circRNA_101308 in CC cells. +other 32606970 hsa-mir-196b Uterine Cervical Neoplasms 3p were found to be sponged by circRNA_101308 in CC cells. +other 32606970 hsa-mir-335 Uterine Cervical Neoplasms 3p were found to be sponged by circRNA_101308 in CC cells. +genetics_overexpression_promote 32606969 hsa-mir-34a Nasopharyngeal Carcinoma In NPC cells, overexpression of MCM3AP-AS1 did not affect the expression of miR34a, while overexpression of miR-34a led to downregulated MCM3AP-AS1. +genetics_knock down_promote 32606965 hsa-mir-299 Colorectal Neoplasms CONCLUSION: The experiments and analyses support our hypothesis that knockdown of lncRNA HCP5 suppresses the progression of colorectal cancer by miR +other 32606949 hsa-mir-590 Breast Neoplasms LINC00657 can participate in the biological behavior process of breast carcinoma by regulating miR-590-3p/GOLPH3 signal. +lncRNA target 32606933 hsa-mir-498 Adenocarcinoma of Lung CONCLUSION: HOTAIRM1 suppressed the proliferation and invasion of ADC cells via the modulation of miR-498/WWOX axis. +lncRNA target 32606930 hsa-mir-204 Colonic Neoplasms DISCUSSION: The present study demonstrated that DSCAM-AS1 acted as an oncogenic lncRNA in CC progression by regulating miR-204/SOX4 axis and DSCAM-AS1 may serve as a novel therapeutic target in the treatment of colon cancer. +lncRNA target 32606929 hsa-mir-379 Nasopharyngeal Carcinoma 5p was downregulated in NPC cell lines, and its exotic expression inhibited EMT to reduce the migration and invasion of NPC cells. +exosome 32606925 hsa-mir-615 Carcinoma, Non-Small-Cell Lung CONCLUSION: Our study demonstrated that exosomal H19 facilitated erlotinib resistance in NSCLC via miR +genetics_overexpression_promote 32606920 hsa-mir-100 Chordoma Overexpression of miR +genetics_knock down_promote 32606808 hsa-mir-335 Carcinoma, Non-Small-Cell Lung 3p) could act as a target of CASC9 in NSCLC and the inhibition effect of CASC9 knockdown on NSCLC progression required the activity of miR +other 32606803 hsa-mir-375 Colorectal Neoplasms Circ-PRKDC Contributes to 5-Fluorouracil Resistance of Colorectal Cancer Cells by Regulating miR-375/FOXM1 Axis and Wnt/β-Catenin Pathway. +lncRNA target 32606801 hsa-mir-185 Colonic Neoplasms 5p/CDK4/CDK6 axis, and lnc HAGLR might be potential target for colon cancer. +target gene 32606796 hsa-mir-1 Carcinoma, Renal Cell Long Non-Coding RNA TUG1 Promotes Cell Proliferation and Inhibits Cell Apoptosis, Autophagy in Clear Cell Renal Cell Carcinoma via MiR-31-5p/FLOT1 Axis. +circRNA target 32606783 hsa-mir-1248 Squamous Cell Carcinoma of Head and Neck And downregulation of hsa_circ_0036722 could promote the proliferation of LSCC cell line through upregulating miR-1248. CONCLUSION: Our results indicated that hsa_circ_0036722 was downregulated in LSCC, which regulate the function of RHCG in LSCC via inhibiting miR-1248, and it could serve as a potential diagnostic marker for LSCC. +target gene 32606775 hsa-mir-101 Colonic Neoplasms Eicosapentaenoic acid's metabolism of 15-LOX-1 promotes the expression of miR-101 thus inhibits Cox2 pathway in colon cancer. +lncRNA target 32606771 hsa-mir-195 Lymphoma, Large B-Cell, Diffuse CONCLUSION: SNHG12 predicts poor clinical outcome and serves as a novel oncogene in DLBCL via miR-195 sponging. +other 32606770 hsa-mir-411 Breast Neoplasms 5p. +other 32606768 hsa-mir-30 Colonic Neoplasms CONCLUSION: The data of this study demonstrated that the hsa_circRNA_000166 could upregulated the expression of gene ELK1 by sponging miR5p, which may contribute to a better understanding of the regulatory circRNA/miRNA/mRNA network and CC pathogenesis. +target gene 32606766 hsa-mir-92a Prostatic Neoplasms MicroRNA-92a Targets SERTAD3 and Regulates the Growth, Invasion, and Migration of Prostate Cancer Cells via the P53 Pathway. +other 32606763 hsa-mir-423 Breast Neoplasms miR-423 Promotes Breast Cancer Invasion by Activating NF-κB Signaling. +other 32606755 hsa-mir-124 Ovarian Neoplasms MiR-124-3p.1 Sensitizes Ovarian Cancer Cells to Mitochondrial Apoptosis Induced by Carboplatin. +genetics_knock down_promote 32606751 hsa-mir-1299 Ovarian Neoplasms Moreover, knockdown of RHPN1-AS1 significantly inhibited the proliferation, migration and invasion of OC cells, and bioinformatics analysis identified that miR-1299 was sponged by RHPN1-AS1 in OC cells. CONCLUSION: Our study demonstrates that RHPN1-AS1 promotes OC progression via sponging miR-1299, suggesting RHPN1-AS1 may be a novel therapeutic target. +transcription factor target 32606749 hsa-mir-520a Stomach Neoplasms The upregulation of miR-520a-3p was partly contributed to the inhibitory effect of ropivacaine on GC cell lines. CONCLUSION: Our results suggested that Rop decreased growth, migration and invasion of GC cells via regulating miR-520a-3p expression and further inactivated WEE1 and PI3K/AKT signaling pathways. +lncRNA target 32606747 hsa-mir-155 Colorectal Neoplasms 5P can reverse the inhibitory effect of knocking down PTTG3P on the malignant progression of CRC. +target gene 32606743 hsa-mir-212 Carcinoma, Hepatocellular FOXA1 Promotes Cell Proliferation and Suppresses Apoptosis in HCC by Directly Regulating miR-212-3p/FOXA1/AGR2 Signaling Pathway. +circulation_biomarker_diagnosis_up 32606735 hsa-mir-203a Lung Neoplasms Low-Temperature Plasma Suppresses Proliferation and Induces Apoptosis in Lung Cancer Cells by Regulating the miR-203a/BIRC5 Axis. +target gene 32606734 hsa-mir-183 Glioma circ_0079586 Predicts Poor Prognosis and Accelerates Progression in Glioma via Interactions with the miR-183-5p/MDM4 Signaling Pathway. +genetics_knock down_suppress 32606732 hsa-mir-199a Carcinoma, Hepatocellular CONCLUSION: CircFoxo3 knockdown reduces and circFoxo3 overexpression enhances HCC cell invasion and tumor growth through regulation of miR-199a-5p/ABCC1 axis. +genetics_knock down_promote 32606725 hsa-mir-1290 Nasopharyngeal Carcinoma Overexpression of ZNF667-AS1 or suppression of miR-1290 inhibited tumorigenicity of NPC cells in vivo. +genetics_GWAS 32606706 hsa-mir-34b Depressive Disorder, Major Therefore, we aimed to identify and analyze the impact of expression and genetic variation of miR-34b/c on cognitive dysfunction in MDD. +other 32606706 hsa-mir-34c Depressive Disorder, Major CONCLUSION: Our findings suggest that changes in miR-34c expression level have important impacts on cognitive function in patients with MDD. +other 32606706 hsa-mir-34c Cognition Disorders CONCLUSION: Our findings suggest that changes in miR-34c expression level have important impacts on cognitive function in patients with MDD. +genetics_GWAS 32606706 hsa-mir-34b Cognition Disorders Therefore, we aimed to identify and analyze the impact of expression and genetic variation of miR-34b/c on cognitive dysfunction in MDD. +other 32606648 hsa-mir-1265 Pulmonary Disease, Chronic Obstructive Moreover, the hsa_circRNA_0008672/miR-1265/MAPK1 axis may contribute to the pathogenesis of COPD, warranting further investigation. +lncRNA target 32606599 hsa-mir-27a Subarachnoid Hemorrhage PURPOSE: To investigate the effects of nimodipine and lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1)/miR-27a/microtubule-associated protein tau (MAPT) axis on CI after SAH. CONCLUSION: Nimodipine can improve CI after SAH in rats through the lncRNA NEAT1/miR-27a/MAPT axis. +other 32606425 hsa-mir-107 Fibrosis, Renal miR-15b, miR-21, and miR-6216 were upregulated and miR-107 was downregulated in the fibrosis model. +other 32606425 hsa-mir-15b Fibrosis, Renal miR-15b, miR-21, and miR-6216 were upregulated and miR-107 was downregulated in the fibrosis model. +other 32606425 hsa-mir-21 Fibrosis, Renal miR-15b, miR-21, and miR-6216 were upregulated and miR-107 was downregulated in the fibrosis model. +other 32605923 hsa-mir-378 Neurologic Manifestations This study aims to investigate the regulatory mechanisms of the pathway consisting of MEG3 (maternally expressed gene 3), microRNA-378 (miR-378), and GRB2 (growth factor receptor-bound protein 2) in neuronal autophagy and neurological functional impairment in ischemic stroke. Taken together, these findings suggested that miR-378 might protect against neuronal autophagy and neurological functional impairment and proposed that a MEG3/miR-378/GRB2 regulatory axis contributed to better understanding of the pathophysiology of ischemic stroke. +other 32605923 hsa-mir-378 Ischemic Stroke This study aims to investigate the regulatory mechanisms of the pathway consisting of MEG3 (maternally expressed gene 3), microRNA-378 (miR-378), and GRB2 (growth factor receptor-bound protein 2) in neuronal autophagy and neurological functional impairment in ischemic stroke. Taken together, these findings suggested that miR-378 might protect against neuronal autophagy and neurological functional impairment and proposed that a MEG3/miR-378/GRB2 regulatory axis contributed to better understanding of the pathophysiology of ischemic stroke. +genetics_GWAS 32605607 hsa-mir-18b Amyotrophic Lateral Sclerosis CONCLUSIONS: Our data indicate that SOD1 mutation decreases miR-18b-5p, which sequentially regulates Hif1alpha, Mef2c, miR-206, Mctp1 and Rarb in fALS-linked SOD1 mutation. +other 32605588 hsa-mir-23a Breast Neoplasms Genes differentially co-expressed between luminal B and triple-negative breast cancer (TNBC) were connected with sphingolipid metabolism and predicted to be co-regulated by miR-23a. +other 32605588 hsa-mir-23a Triple Negative Breast Neoplasms Genes differentially co-expressed between luminal B and triple-negative breast cancer (TNBC) were connected with sphingolipid metabolism and predicted to be co-regulated by miR-23a. +lncRNA target 32605563 hsa-mir-1825 Glioblastoma CONCLUSION: In conclusion, miR-1825 upregulation suppressed GBM progression by targeting CDK14 through Wnt/beta-catenin pathway. +transcription factor target 32605511 hsa-mir-1247 Cardiomyopathies 3p restoration exhibited protective effects on H/R-induced cardiomyocyte injury through targeting BCL2L11 and caspase-2, implying that miR +other 32605105 hsa-mir-99a Hepatitis C In this study, we investigated the role of microRNA-99a (miR-99a) in hepatitis C virus (HCV) replication and lipogenesis in hepatocytes. Cell-culture-derived HCV (HCVcc) infection caused down-regulation of miR-99a in Huh-7 cells, and the relative levels of miR-99a were significantly lower in the sera of the HCV-infected patients than in those of healthy controls. +circulation_biomarker_diagnosis_up 32604783 hsa-mir-193a Lung Diseases, Interstitial Using polymerase chain reaction PCR-Array technology (24 ILA and 24 Ctrl, screening cohort) and reverse-transcriptase quantitative polymerase chain reaction (RT-qPCR) (57 ILA and 88 Ctr, independent validation cohort) we identified seven up-regulated miRNAs in serum of ILA compared to Ctrl (miR-193a-5p, p < 0.0001; miR +circulation_biomarker_diagnosis_up 32604783 hsa-mir-126 Lung Diseases, Interstitial Using polymerase chain reaction PCR-Array technology (24 ILA and 24 Ctrl, screening cohort) and reverse-transcriptase quantitative polymerase chain reaction (RT-qPCR) (57 ILA and 88 Ctr, independent validation cohort) we identified seven up-regulated miRNAs in serum of ILA compared to Ctrl (miR-193a-5p, p < 0.0001; miR +circulation_biomarker_diagnosis_up 32604783 hsa-mir-200c Lung Diseases, Interstitial Using polymerase chain reaction PCR-Array technology (24 ILA and 24 Ctrl, screening cohort) and reverse-transcriptase quantitative polymerase chain reaction (RT-qPCR) (57 ILA and 88 Ctr, independent validation cohort) we identified seven up-regulated miRNAs in serum of ILA compared to Ctrl (miR-193a-5p, p < 0.0001; miR +circulation_biomarker_diagnosis_up 32604783 hsa-mir-34a Lung Diseases, Interstitial Using polymerase chain reaction PCR-Array technology (24 ILA and 24 Ctrl, screening cohort) and reverse-transcriptase quantitative polymerase chain reaction (RT-qPCR) (57 ILA and 88 Ctr, independent validation cohort) we identified seven up-regulated miRNAs in serum of ILA compared to Ctrl (miR-193a-5p, p < 0.0001; miR +circulation_biomarker_diagnosis_up 32604783 hsa-mir-16 Lung Diseases, Interstitial Using polymerase chain reaction PCR-Array technology (24 ILA and 24 Ctrl, screening cohort) and reverse-transcriptase quantitative polymerase chain reaction (RT-qPCR) (57 ILA and 88 Ctr, independent validation cohort) we identified seven up-regulated miRNAs in serum of ILA compared to Ctrl (miR-193a-5p, p < 0.0001; miR +circulation_biomarker_diagnosis_up 32604783 hsa-mir-502 Lung Diseases, Interstitial Using polymerase chain reaction PCR-Array technology (24 ILA and 24 Ctrl, screening cohort) and reverse-transcriptase quantitative polymerase chain reaction (RT-qPCR) (57 ILA and 88 Ctr, independent validation cohort) we identified seven up-regulated miRNAs in serum of ILA compared to Ctrl (miR-193a-5p, p < 0.0001; miR +circulation_biomarker_diagnosis_up 32604783 hsa-mir-21 Lung Diseases, Interstitial Using polymerase chain reaction PCR-Array technology (24 ILA and 24 Ctrl, screening cohort) and reverse-transcriptase quantitative polymerase chain reaction (RT-qPCR) (57 ILA and 88 Ctr, independent validation cohort) we identified seven up-regulated miRNAs in serum of ILA compared to Ctrl (miR-193a-5p, p < 0.0001; miR +lncRNA target 32603818 hsa-mir-186 Atherosclerosis SIGNIFICANCE: In conclusion, these results show the essential roles of E2F1/SNHG7/miR5p/MMP2 axis on the proliferation and migration of endothelial cells, providing a potential therapeutic target for atherosclerosis. +other 32603552 hsa-mir-1305 Glioma In addition, miR-378b and miR-1305 were decreased 6.8- and 6-fold, respectively, whereas miR-451a was increased 2.7-fold (adjusted P < 0.05) in NF1-PAs compared to non-neoplastic NF1 patient brain specimens (n = 2). +genetics_knock down_suppress 32603552 hsa-mir-10b Glioma miR-10b-5p knockdown resulted in decreased invasion in NF1-deficient LN229 high-grade glioma line, whereas its overexpression in the NF1-PA derived line (JHH-NF1-PA1) led to increased invasion. +genetics_knock down_suppress 32603552 hsa-mir-10b Neurofibromatosis 1 miR-10b-5p knockdown resulted in decreased invasion in NF1-deficient LN229 high-grade glioma line, whereas its overexpression in the NF1-PA derived line (JHH-NF1-PA1) led to increased invasion. +other 32603552 hsa-mir-20a Glioma RESULTS: miR-10b-5p, miR-135b-5p, miR-196a-5p, miR-196b-5p, miR5p and miR-320a (adjusted P < 0.05) were increased> 3-fold in NF1-HGG relative to NF1-PA tumours. +other 32603552 hsa-mir-20a Neurofibromatosis 1 RESULTS: miR-10b-5p, miR-135b-5p, miR-196a-5p, miR-196b-5p, miR5p and miR-320a (adjusted P < 0.05) were increased> 3-fold in NF1-HGG relative to NF1-PA tumours. +other 32603552 hsa-mir-135b Glioma RESULTS: miR-10b-5p, miR-135b-5p, miR-196a-5p, miR-196b-5p, miR5p and miR-320a (adjusted P < 0.05) were increased> 3-fold in NF1-HGG relative to NF1-PA tumours. +other 32603552 hsa-mir-1305 Neurofibromatosis 1 In addition, miR-378b and miR-1305 were decreased 6.8- and 6-fold, respectively, whereas miR-451a was increased 2.7-fold (adjusted P < 0.05) in NF1-PAs compared to non-neoplastic NF1 patient brain specimens (n = 2). +other 32603552 hsa-mir-1247 Neurofibromatosis 1 RESULTS: miR-10b-5p, miR-135b-5p, miR-196a-5p, miR-196b-5p, miR5p and miR-320a (adjusted P < 0.05) were increased> 3-fold in NF1-HGG relative to NF1-PA tumours. +other 32603552 hsa-mir-378b Neurofibromatosis 1 In addition, miR-378b and miR-1305 were decreased 6.8- and 6-fold, respectively, whereas miR-451a was increased 2.7-fold (adjusted P < 0.05) in NF1-PAs compared to non-neoplastic NF1 patient brain specimens (n = 2). +other 32603552 hsa-mir-196b Neurofibromatosis 1 RESULTS: miR-10b-5p, miR-135b-5p, miR-196a-5p, miR-196b-5p, miR5p and miR-320a (adjusted P < 0.05) were increased> 3-fold in NF1-HGG relative to NF1-PA tumours. +other 32603552 hsa-mir-196a Glioma RESULTS: miR-10b-5p, miR-135b-5p, miR-196a-5p, miR-196b-5p, miR5p and miR-320a (adjusted P < 0.05) were increased> 3-fold in NF1-HGG relative to NF1-PA tumours. +other 32603552 hsa-mir-196b Glioma RESULTS: miR-10b-5p, miR-135b-5p, miR-196a-5p, miR-196b-5p, miR5p and miR-320a (adjusted P < 0.05) were increased> 3-fold in NF1-HGG relative to NF1-PA tumours. +other 32603552 hsa-mir-378b Glioma In addition, miR-378b and miR-1305 were decreased 6.8- and 6-fold, respectively, whereas miR-451a was increased 2.7-fold (adjusted P < 0.05) in NF1-PAs compared to non-neoplastic NF1 patient brain specimens (n = 2). +other 32603552 hsa-mir-1247 Glioma RESULTS: miR-10b-5p, miR-135b-5p, miR-196a-5p, miR-196b-5p, miR5p and miR-320a (adjusted P < 0.05) were increased> 3-fold in NF1-HGG relative to NF1-PA tumours. +other 32603552 hsa-mir-451a Neurofibromatosis 1 In addition, miR-378b and miR-1305 were decreased 6.8- and 6-fold, respectively, whereas miR-451a was increased 2.7-fold (adjusted P < 0.05) in NF1-PAs compared to non-neoplastic NF1 patient brain specimens (n = 2). +other 32603552 hsa-mir-451a Glioma In addition, miR-378b and miR-1305 were decreased 6.8- and 6-fold, respectively, whereas miR-451a was increased 2.7-fold (adjusted P < 0.05) in NF1-PAs compared to non-neoplastic NF1 patient brain specimens (n = 2). +other 32603552 hsa-mir-135b Neurofibromatosis 1 RESULTS: miR-10b-5p, miR-135b-5p, miR-196a-5p, miR-196b-5p, miR5p and miR-320a (adjusted P < 0.05) were increased> 3-fold in NF1-HGG relative to NF1-PA tumours. +other 32603552 hsa-mir-196a Neurofibromatosis 1 RESULTS: miR-10b-5p, miR-135b-5p, miR-196a-5p, miR-196b-5p, miR5p and miR-320a (adjusted P < 0.05) were increased> 3-fold in NF1-HGG relative to NF1-PA tumours. +transcription factor target 32602850 hsa-mir-183 Cerebral Hemorrhage Our results indicate that miRNA5p and HO-1 are promising therapeutic targets for controlling inflammation and oxidative damage after hemorrhagic stroke. +other 32602632 hsa-mir-431 Thyroid Cancer, Papillary 5p bind with cyclin-dependent kinase (CDK) 14 and showed negative correlation with CDK14 in PTC patients. +transcription factor target 32602617 hsa-mir-145 Multiple Sclerosis 5p is dysregulated. +transcription factor target 32602617 hsa-mir-145 Demyelinating Diseases 5p is dysregulated. +other 32602607 hsa-mir-23b Glioma "RESULTS: SNHG17 expression was markedly raised in glioma tissues, which was positively correlated with ZHX1 expression and negatively associated with the expression of miR-23b-3p. CONCLUSIONS: SNHG17 is a ""competing endogenous RNA"" with respect to modulating ZHX1 expression by adsorbing miR-23b-3p and thereby promoting glioma progression." +other 32602388 hsa-mir-210 psoriasis 1 In conclusion, the expression of miRNA-155, miRNA-210, and miRNA-20b is exaggerated in psoriasis and they may be involved in disease pathogenesis. +other 32602388 hsa-mir-155 psoriasis 1 In conclusion, the expression of miRNA-155, miRNA-210, and miRNA-20b is exaggerated in psoriasis and they may be involved in disease pathogenesis. +other 32602388 hsa-mir-20b psoriasis 1 In conclusion, the expression of miRNA-155, miRNA-210, and miRNA-20b is exaggerated in psoriasis and they may be involved in disease pathogenesis. +other 32602286 hsa-mir-138-1 Carcinoma, Renal Cell 1 in renal cell carcinoma indicates the feasibility of further studies on the probable diagnostic utility of these markers. +lncRNA target 32602212 hsa-mir-519d Carcinoma, Non-Small-Cell Lung CONCLUSIONS: Collectively, circ_0007385 deletion could function anti-tumor role in NSCLC by suppressing malignant behaviors and DDP resistance in vitro and in vivo via circ_0007385/miR-519d-3p/HMGB1 axis. +circulation_biomarker_diagnosis_down 32602122 hsa-mir-140 Inflammation 5p, a marker of ALI, was downregulated in the plasma, lung, liver, and kidney of CEES-exposed rats, with a concomitant increase in the expression of the inflammation markers IL-6 and IL-1alpha and the coagulation marker tissue factor (F3). +other 32602050 hsa-mir-16-1 Infertility Although these changes are particularly noted in male infertility, little is known about the effects of increased miR1 in sperm from infertile men. +other 32602050 hsa-mir-16-1 Infertility, Male Although these changes are particularly noted in male infertility, little is known about the effects of increased miR1 in sperm from infertile men. +transcription factor target 32602014 hsa-mir-34a Breast Neoplasms IL-6 was found to inhibit miR-34a transcription and induce PTPRD expression in breast cancer and breast epithelial cells, whereas PTPRD was shown to mediate activated STAT3 dephosphorylation and to be a conserved, direct target of miR-34a. +genetics_overexpression_suppress 32601379 hsa-mir-135b Colorectal Neoplasms Analyzing the functions of miR-3135b, a small non-coding RNA with unknown functions, we found that its forced overexpression attenuates the Golgi apparatus fragmentation induced by chemotherapeutic drugs in colorectal cancer (CRC) cells. +genetics_overexpression_promote 32601179 hsa-let-7 Neuroblastoma Here, we report that overexpression of either wild-type (WT) LIN28B or a LIN28B mutant that is unable to inhibit let-7 processing increases the penetrance of MYCN-induced neuroblastoma, potentiates the invasion and migration of transformed sympathetic neuroblasts, and drives distant metastases in vivo. +lncRNA target 32600449 hsa-mir-132 Hypoxia-Ischemia, Brain CONCLUSION: Our results suggest that miR3p promotes the beneficial effects of MSC-EXs on brain ischemic injury through protecting cerebral EC functions. +exosome 32600436 hsa-mir-15b Shock, Septic Mechanistic studies demonstrated that exosomal high-mobility group protein 1 (HMGB1) and/or miR-15b-5p and miR-378a-3p induced NET formation through the Akt/mTOR autophagy pathway. +exosome 32600436 hsa-mir-378a Shock, Septic Mechanistic studies demonstrated that exosomal high-mobility group protein 1 (HMGB1) and/or miR-15b-5p and miR-378a-3p induced NET formation through the Akt/mTOR autophagy pathway. +lncRNA target 32600409 hsa-mir-1323 Fractures, Bone CONCLUSIONS: This evidence supports the miR-1323/BMP4 and miR-1323/SMAD4 axes as novel therapeutic targets for atrophic non-union fractures. +other 32600379 hsa-mir-526b Glioma The potential function of SRSF10/circ-ATXN1/miR-526b-3p axis in glioma-associated endothelial cells (GECs) angiogenesis was further studied. +exosome 32600329 hsa-mir-582 Stomach Neoplasms CONCLUSION: Our findings demonstrate that exosomal circSHKBP1 regulates the miR3p/HUR/VEGF pathway, suppresses HSP90 degradation, and promotes GC progression. +lncRNA target 32600285 hsa-mir-146a Asthma RESULTS: miR146a-inhibitor attenuated OVA-induced allergic asthma by increasing Th1 cytokines in OVA-induced allergic asthma model, and the treatment of miR146a-inhibitor can reduce the inflammation caused by asthma, followed by the down-regulation of IL-5 and IL-13 in sorted ILC2. +circulation_biomarker_diagnosis_ns 32600257 hsa-mir-200c Colorectal Neoplasms Retrospective analysis revealed that miR-200c-3p was elevated in CRC tumor tissues, but decreased in the serum exosome in CRC patients. +other 32600091 hsa-mir-518a Lymphoma, Large B-Cell, Diffuse The above results suggest that miR-518a-5p-CCR6 feedback loop plays a critical role in DLBCL development. +circulation_biomarker_diagnosis_ns 32600075 hsa-mir-20a Pulmonary Arterial Hypertension OBJECTIVE: This study aimed to detect circulating microRNA (miR)-17 and miR-20a levels in patients with pulmonary arterial hypertension (PAH), and to investigate whether circulating miR-17 levels are associated with PAH. +circulation_biomarker_prognosis_ns 32600075 hsa-mir-17 Pulmonary Arterial Hypertension Further, we found that circulating miR-17 levels correlated with the 6-minute walk distance, mean pulmonary artery pressure, and mean right atrial pressure in PAH patients. +other 32599985 hsa-mir-204 Breast Neoplasms MiR5p could regulate RIOK1 expression and be involved in BC progression. +lncRNA target 32599739 hsa-mir-5572 sporatic amyotrophic lateral sclerosis Taken together, these results demonstrate that the level of novel miRNA miR-5572 is increased in sALS and that SLC30A3 is one of the target genes regulated by miR-5572. +other 32599467 hsa-mir-708 Multiple Sclerosis The objective of this study was investigation of the role of important confirmed miRNAs, including miR-335, miR-485, miR-542, and miR-708, in the regulation of survivin mRNA in the CD4+ T cells of MS cases. +other 32599467 hsa-mir-335 Multiple Sclerosis The objective of this study was investigation of the role of important confirmed miRNAs, including miR-335, miR-485, miR-542, and miR-708, in the regulation of survivin mRNA in the CD4+ T cells of MS cases. +other 32599467 hsa-mir-485 Multiple Sclerosis The objective of this study was investigation of the role of important confirmed miRNAs, including miR-335, miR-485, miR-542, and miR-708, in the regulation of survivin mRNA in the CD4+ T cells of MS cases. +other 32599451 hsa-mir-19a Optic Nerve Diseases This study uncovers a previously unrecognized involvement of the miR-19a-PTEN axis in RGC axon regeneration, and it demonstrates therapeutic potential of microRNA-mediated restoration of axon regenerative capacity in optic neuropathies. +other 32599321 hsa-mir-590 Intrauterine Adhesion Collectively, our findings provide vital theoretical evidence for explaining the mechanisms of the lncRNA TUG1/miR5p/Fasl axis in the progression of IUA, and may provide a new biomarker for the treatment of IUA patients. +other 32599321 hsa-mir-590 Inflammation Collectively, our findings provide vital theoretical evidence for explaining the mechanisms of the lncRNA TUG1/miR5p/Fasl axis in the progression of IUA, and may provide a new biomarker for the treatment of IUA patients. +other 32599321 hsa-mir-590 Gynatresia Collectively, our findings provide vital theoretical evidence for explaining the mechanisms of the lncRNA TUG1/miR5p/Fasl axis in the progression of IUA, and may provide a new biomarker for the treatment of IUA patients. +circRNA target 32599139 hsa-mir-143 Carcinoma, Non-Small-Cell Lung Taken together, these findings indicated the important role of circTUBA1C/miR3p axis in NSCLC, which may provide a potential target for NSCLC therapy. +exosome 32598931 hsa-mir-454 Breast Neoplasms Thus, our main purpose here was to determine the role of the exosomal microRNA-454 (miR-454) derived by MDA-MB-231 in self-renewal of cancer stem cells (CSCs) in ovarian cancer (OC). SIGNIFICANCE: Altogether, 231-derived exosomes carrying miR-454 disrupted the Wnt pathway by targeting PRRT2, thereby promoting CSC stemness in vitro and OC cell growth in vivo. +exosome 32598931 hsa-mir-454 Ovarian Neoplasms Thus, our main purpose here was to determine the role of the exosomal microRNA-454 (miR-454) derived by MDA-MB-231 in self-renewal of cancer stem cells (CSCs) in ovarian cancer (OC). SIGNIFICANCE: Altogether, 231-derived exosomes carrying miR-454 disrupted the Wnt pathway by targeting PRRT2, thereby promoting CSC stemness in vitro and OC cell growth in vivo. +other 32598816 hsa-mir-143 Cardiomegaly RESULTS: Differentially expressed miRNAs were determined in patients with CHF (regardless of etiology) compared with healthy individuals: miR-182, miR-144, miR-183, miR5p, miR-143 (log2FC >1, FDR p - value. +other 32598816 hsa-mir-486 Cardiomegaly RESULTS: Differentially expressed miRNAs were determined in patients with CHF (regardless of etiology) compared with healthy individuals: miR-182, miR-144, miR-183, miR5p, miR-143 (log2FC >1, FDR p - value. +other 32598816 hsa-mir-144 Cardiomegaly RESULTS: Differentially expressed miRNAs were determined in patients with CHF (regardless of etiology) compared with healthy individuals: miR-182, miR-144, miR-183, miR5p, miR-143 (log2FC >1, FDR p - value. +other 32598816 hsa-mir-182 Cardiomegaly RESULTS: Differentially expressed miRNAs were determined in patients with CHF (regardless of etiology) compared with healthy individuals: miR-182, miR-144, miR-183, miR5p, miR-143 (log2FC >1, FDR p - value. +circulation_biomarker_diagnosis_up 32598698 hsa-mir-21 Cardiomyopathy, Hypertrophic The maximum level of circulating microRNA-21 was detected in patients with symptomatic course of HCM at the age of 45 years. +other 32598517 hsa-mir-126 Carcinoma, Non-Small-Cell Lung 3p may be a biomarker for LUSC early diagnosis and prognosis. +other 32598439 hsa-mir-1307 Inflammatory Bowel Diseases 3p was able to predict disease progression in IBD (HR 1.98, IQR:1.20-3.27;logrank p=1.8010-3), in particular CD (HR 2.81; IQR: 1.11-3.53, p=6.5010-4). +genetics_overexpression_promote 32598181 hsa-mir-212 Carcinoma, Non-Small-Cell Lung In NSCLC cells, overexpression of ELF3-AS1 led to downregulated miR-212 and increased methylation of miR-212 gene. +genetics_overexpression_promote 32598170 hsa-mir-326 Leukemia, Myelogenous, Chronic, BCR-ABL Positive The suppressive roles in IM resistance, cell growth and glycolysis, and the promotional role in apoptosis mediated by miR-326 were abolished by PPFIA1 overexpression in IM-resistant CML cells. Conclusion: circ_0080145 contributes to IM resistance via modulating miR-326/PPFIA1 axis, which might provide a novel avenue for CML therapy. +lncRNA target 32597790 hsa-mir-29b Leukemia, Myeloid, Acute By bioinformatics analysis, DNMT3A expression was found to be positively correlated with several leukemia-associated genes/microRNAs, and DNMT3A was identified as direct targets of miR-429 and miR-29b in AML. +other 32597559 hsa-mir-1207 Osteoarthritis 5p can prevent CHON-001 from LPS-stimulated injury, providing a novel biomarker for OA progression and further advancing treatment of OA. +genetics_overexpression_promote 32597556 hsa-mir-1193 Inflammation Furthermore, overexpression of JAK3 presented auxo-action while depletion of JAK3 exhibited inhibitory effect on the proliferation of MH7A cells with IL-1beta-induced inflammation, which could be weakened by miR-1193 mimic and miR-1193 inhibitor, respectively. +transcription factor target 32597556 hsa-mir-1193 Arthritis, Rheumatoid CONCLUSION: Up-regulation of miR-1193 suppressed the proliferation and expedited the apoptosis of MH7A cells with IL-1beta-induced inflammation through targeting JAK3, which might provide novel understanding on the mechanism underlying RA. +transcription factor target 32597323 hsa-mir-383 Stomach Neoplasms The compound also inhibited migration and invasion of GC cells, which was associated with the up-regulation miR +exosome 32597300 hsa-mir-133b Pre-Eclampsia CONCLUSION: Collectively, we demonstrate that miR-133b is down-regulated and SGK1 is up-regulated in PE, and miR-133b derived from exosomes in hUM-MSCs facilitates trophoblast cell proliferation, migration and invasion in PE via constraining SGK1. +lncRNA target 32597160 hsa-mir-5580 Squamous Cell Carcinoma of Head and Neck Conclusion: The roles of DEMs such as hsa-mir3p in OSCC through interactions with DEGs CD44, ACLY, ACTR3, STAT1, LAMC2 and YWHAZ may offer a suitable candidate biomarker pattern for diagnosis, prognosis and treatment processes in OSCC. +lncRNA target 32597022 hsa-mir-296 Diabetic Nephropathies In conclusion, circ-AKT3 inhibited the extracellular matrix accumulation in diabetic nephropathy mesangial cells through modulating miR +genetics_overexpression_promote 32596968 hsa-mir-3677 Carcinoma, Hepatocellular In conclusion, the overexpression of miR +genetics_knock down_promote 32596959 hsa-mir-140 Carcinoma, Renal Cell 5p promoted the proliferation, migration, and invasion of RCC cells in vitro, and knockdown of miR +genetics_GWAS 32596945 hsa-mir-146a Urinary Bladder Neoplasms As an SNP regulating the expression of miR-146a, the rs2910164 G > C SNP could be utilized as a biomarker for BC relapse. +genetics_knock down_suppress 32596384 hsa-mir-218 Osteosarcoma Mechanically, we found that circEIF4G2 could directly bind to miR-218, and miR-218 mediated the effect of circEIF4G2 knockdown on OS progression. +other 32596382 hsa-mir-204 cataract 32 multiple types The expression of miR-34a and miR-204 was decreased, and the levels of Snail1 and Zeb1 were elevated in human posterior capsule opacification- (PCO-) attached LECs and the LECs obtained from anterior subcapsular cataract (ASC) by quantitative RT-PCR (qRT-PCR). +other 32596382 hsa-mir-34a Capsule Opacification The expression of miR-34a and miR-204 was decreased, and the levels of Snail1 and Zeb1 were elevated in human posterior capsule opacification- (PCO-) attached LECs and the LECs obtained from anterior subcapsular cataract (ASC) by quantitative RT-PCR (qRT-PCR). +other 32596382 hsa-mir-34a Atypical Squamous Cells of the Cervix The expression of miR-34a and miR-204 was decreased, and the levels of Snail1 and Zeb1 were elevated in human posterior capsule opacification- (PCO-) attached LECs and the LECs obtained from anterior subcapsular cataract (ASC) by quantitative RT-PCR (qRT-PCR). +other 32596382 hsa-mir-204 Atypical Squamous Cells of the Cervix The expression of miR-34a and miR-204 was decreased, and the levels of Snail1 and Zeb1 were elevated in human posterior capsule opacification- (PCO-) attached LECs and the LECs obtained from anterior subcapsular cataract (ASC) by quantitative RT-PCR (qRT-PCR). +other 32596382 hsa-mir-34a cataract 32 multiple types The expression of miR-34a and miR-204 was decreased, and the levels of Snail1 and Zeb1 were elevated in human posterior capsule opacification- (PCO-) attached LECs and the LECs obtained from anterior subcapsular cataract (ASC) by quantitative RT-PCR (qRT-PCR). +other 32596382 hsa-mir-204 Polycystic Ovary Syndrome The expression of miR-34a and miR-204 was decreased, and the levels of Snail1 and Zeb1 were elevated in human posterior capsule opacification- (PCO-) attached LECs and the LECs obtained from anterior subcapsular cataract (ASC) by quantitative RT-PCR (qRT-PCR). +other 32596382 hsa-mir-204 Capsule Opacification The expression of miR-34a and miR-204 was decreased, and the levels of Snail1 and Zeb1 were elevated in human posterior capsule opacification- (PCO-) attached LECs and the LECs obtained from anterior subcapsular cataract (ASC) by quantitative RT-PCR (qRT-PCR). +other 32596382 hsa-mir-34a Polycystic Ovary Syndrome The expression of miR-34a and miR-204 was decreased, and the levels of Snail1 and Zeb1 were elevated in human posterior capsule opacification- (PCO-) attached LECs and the LECs obtained from anterior subcapsular cataract (ASC) by quantitative RT-PCR (qRT-PCR). +lncRNA target 32596373 hsa-mir-338 Lymphoma, Large B-Cell, Diffuse Overall survival analysis revealed that MAFA-AS1, hsa-mir-338, and hsa-mir-891a were related with prognosis of DLBCL (p value = 0.027, 0.039, and 0.022, respectively). CONCLUSION: We constructed a coexpression module related with histological type and identified three candidate genes (MAFA-AS1, hsa-mir-338, and hsa-mir-891a) that possessed potential value as prognostic biomarkers and therapeutic targets of DLBCL. +lncRNA target 32596373 hsa-mir-891a Lymphoma, Large B-Cell, Diffuse Overall survival analysis revealed that MAFA-AS1, hsa-mir-338, and hsa-mir-891a were related with prognosis of DLBCL (p value = 0.027, 0.039, and 0.022, respectively). CONCLUSION: We constructed a coexpression module related with histological type and identified three candidate genes (MAFA-AS1, hsa-mir-338, and hsa-mir-891a) that possessed potential value as prognostic biomarkers and therapeutic targets of DLBCL. +other 32596340 hsa-mir-31 Cerebral Hemorrhage CONCLUSION: miR3p regulated the inflammatory response after cerebral hemorrhage by negatively regulating the expression of NLRP6. +genetics_overexpression_promote 32596290 hsa-mir-193b Stomach Neoplasms In vitro, miR193b overexpression inhibited cell survival and induced apoptosis in GC cell lines, indicating that miR193b plays a role in the development of gastric cancer. +other 32596148 hsa-mir-7 Carcinoma, Non-Small-Cell Lung Background: We previously identified a 12-microRNA (miRNA) panel (miRNA-17, miRNA-146a, miRNA-200b, miRNA-182, miRNA-155, miRNA-221, miRNA-205, miRNA-126, miRNA-7, miRNA-21, miRNA-145, and miRNA-210) that aided in the early diagnosis of non-small cell lung cancer (NSCLC). +other 32596148 hsa-mir-17 Carcinoma, Non-Small-Cell Lung Background: We previously identified a 12-microRNA (miRNA) panel (miRNA-17, miRNA-146a, miRNA-200b, miRNA-182, miRNA-155, miRNA-221, miRNA-205, miRNA-126, miRNA-7, miRNA-21, miRNA-145, and miRNA-210) that aided in the early diagnosis of non-small cell lung cancer (NSCLC). +other 32596148 hsa-mir-21 Carcinoma, Non-Small-Cell Lung Background: We previously identified a 12-microRNA (miRNA) panel (miRNA-17, miRNA-146a, miRNA-200b, miRNA-182, miRNA-155, miRNA-221, miRNA-205, miRNA-126, miRNA-7, miRNA-21, miRNA-145, and miRNA-210) that aided in the early diagnosis of non-small cell lung cancer (NSCLC). +other 32596148 hsa-mir-182 Carcinoma, Non-Small-Cell Lung Background: We previously identified a 12-microRNA (miRNA) panel (miRNA-17, miRNA-146a, miRNA-200b, miRNA-182, miRNA-155, miRNA-221, miRNA-205, miRNA-126, miRNA-7, miRNA-21, miRNA-145, and miRNA-210) that aided in the early diagnosis of non-small cell lung cancer (NSCLC). +other 32596148 hsa-mir-146a Carcinoma, Non-Small-Cell Lung Background: We previously identified a 12-microRNA (miRNA) panel (miRNA-17, miRNA-146a, miRNA-200b, miRNA-182, miRNA-155, miRNA-221, miRNA-205, miRNA-126, miRNA-7, miRNA-21, miRNA-145, and miRNA-210) that aided in the early diagnosis of non-small cell lung cancer (NSCLC). +other 32596148 hsa-mir-145 Carcinoma, Non-Small-Cell Lung Background: We previously identified a 12-microRNA (miRNA) panel (miRNA-17, miRNA-146a, miRNA-200b, miRNA-182, miRNA-155, miRNA-221, miRNA-205, miRNA-126, miRNA-7, miRNA-21, miRNA-145, and miRNA-210) that aided in the early diagnosis of non-small cell lung cancer (NSCLC). +other 32596148 hsa-mir-221 Carcinoma, Non-Small-Cell Lung Background: We previously identified a 12-microRNA (miRNA) panel (miRNA-17, miRNA-146a, miRNA-200b, miRNA-182, miRNA-155, miRNA-221, miRNA-205, miRNA-126, miRNA-7, miRNA-21, miRNA-145, and miRNA-210) that aided in the early diagnosis of non-small cell lung cancer (NSCLC). +other 32596148 hsa-mir-205 Carcinoma, Non-Small-Cell Lung Background: We previously identified a 12-microRNA (miRNA) panel (miRNA-17, miRNA-146a, miRNA-200b, miRNA-182, miRNA-155, miRNA-221, miRNA-205, miRNA-126, miRNA-7, miRNA-21, miRNA-145, and miRNA-210) that aided in the early diagnosis of non-small cell lung cancer (NSCLC). +other 32596148 hsa-mir-126 Carcinoma, Non-Small-Cell Lung Background: We previously identified a 12-microRNA (miRNA) panel (miRNA-17, miRNA-146a, miRNA-200b, miRNA-182, miRNA-155, miRNA-221, miRNA-205, miRNA-126, miRNA-7, miRNA-21, miRNA-145, and miRNA-210) that aided in the early diagnosis of non-small cell lung cancer (NSCLC). +other 32596148 hsa-mir-155 Carcinoma, Non-Small-Cell Lung Background: We previously identified a 12-microRNA (miRNA) panel (miRNA-17, miRNA-146a, miRNA-200b, miRNA-182, miRNA-155, miRNA-221, miRNA-205, miRNA-126, miRNA-7, miRNA-21, miRNA-145, and miRNA-210) that aided in the early diagnosis of non-small cell lung cancer (NSCLC). +other 32596148 hsa-mir-200b Carcinoma, Non-Small-Cell Lung Background: We previously identified a 12-microRNA (miRNA) panel (miRNA-17, miRNA-146a, miRNA-200b, miRNA-182, miRNA-155, miRNA-221, miRNA-205, miRNA-126, miRNA-7, miRNA-21, miRNA-145, and miRNA-210) that aided in the early diagnosis of non-small cell lung cancer (NSCLC). +transcription factor target 32596042 hsa-mir-184 Echinococcosis Surprisingly, the Echinococcus miR-184 plays a role in the pathogenicity regulation by targeting nine TFs and one ncRNA in humans. CONCLUSION: The results show that the miRNA-184 of Echinococcus can regulate the pathogenic process through various biological functions and pathways. +other 32596004 hsa-mir-205 Stomach Neoplasms However, the role of miR-205 in human gastric cancer (GC) epithelial-mesenchymal transition (EMT) remains unclear. +transcription factor target 32595704 hsa-mir-338 Colorectal Neoplasms CONCLUSION: These findings suggest that lnc-HSD17B11-1:1 promotes CRC progression through lnc-HSD17B11-1:1/miR3p/MACC1 axis and this might serve as a new diagnostic marker or target for treatment of CRC. +other 32595699 hsa-mir-222 Tetralogy of Fallot In the present study, a total of 529 DEmRNAs, including 115 downregulated and 414 upregulated DEmRNAs, and 7 significantly upregulated DemiRs, including miR-499, miR-23b, miR-222, miR-1275, miR-93, miR-155, and miR-187, were found between TOF and control groups. +other 32595699 hsa-mir-23b Tetralogy of Fallot In the present study, a total of 529 DEmRNAs, including 115 downregulated and 414 upregulated DEmRNAs, and 7 significantly upregulated DemiRs, including miR-499, miR-23b, miR-222, miR-1275, miR-93, miR-155, and miR-187, were found between TOF and control groups. +other 32595699 hsa-mir-93 Tetralogy of Fallot In the present study, a total of 529 DEmRNAs, including 115 downregulated and 414 upregulated DEmRNAs, and 7 significantly upregulated DemiRs, including miR-499, miR-23b, miR-222, miR-1275, miR-93, miR-155, and miR-187, were found between TOF and control groups. +other 32595699 hsa-mir-155 Tetralogy of Fallot In the present study, a total of 529 DEmRNAs, including 115 downregulated and 414 upregulated DEmRNAs, and 7 significantly upregulated DemiRs, including miR-499, miR-23b, miR-222, miR-1275, miR-93, miR-155, and miR-187, were found between TOF and control groups. +other 32595699 hsa-mir-1275 Tetralogy of Fallot In the present study, a total of 529 DEmRNAs, including 115 downregulated and 414 upregulated DEmRNAs, and 7 significantly upregulated DemiRs, including miR-499, miR-23b, miR-222, miR-1275, miR-93, miR-155, and miR-187, were found between TOF and control groups. +other 32595699 hsa-mir-499 Tetralogy of Fallot In the present study, a total of 529 DEmRNAs, including 115 downregulated and 414 upregulated DEmRNAs, and 7 significantly upregulated DemiRs, including miR-499, miR-23b, miR-222, miR-1275, miR-93, miR-155, and miR-187, were found between TOF and control groups. +other 32595699 hsa-mir-187 Tetralogy of Fallot In the present study, a total of 529 DEmRNAs, including 115 downregulated and 414 upregulated DEmRNAs, and 7 significantly upregulated DemiRs, including miR-499, miR-23b, miR-222, miR-1275, miR-93, miR-155, and miR-187, were found between TOF and control groups. +circulation_biomarker_diagnosis_up 32595646 hsa-mir-125a Thyroiditis, Autoimmune MiR-125a-5p expression positively correlated with the proportion of circulating Th1 cells and the serum concentrations of anti-thyroperoxidase antibodies in the HT patients. +circulation_biomarker_diagnosis_ns 32595526 hsa-mir-126 Acute Coronary Syndrome Receiving operating characteristic curve analysis demonstrated the diagnostic efficiency of serum exosomal miR-126, miR-21, and PTEN levels for predicting AMI and UA. +lncRNA target 32595418 hsa-mir-577 Carcinoma, Renal Cell CONCLUSION: LINC01094 facilitates ccRCC radioresistance by targeting miR-577/CHEK2/FOXM1 axis, blazing a new trail for overcoming radioresistance in ccRCC. +lncRNA target 32594835 hsa-let-7a Squamous Cell Carcinoma of Head and Neck miR-let-7a is low expression in OSCC, and promotes tumor development by directly targeting c-Myc. +transcription factor target 32594834 hsa-mir-425 Colorectal Neoplasms 5p may promote tumorigenesis and metastasis through activating CTNND1-mediated beta-catenin pathway, which may provide therapeutic targets for human CRC. +transcription factor target 32594829 hsa-mir-203 psoriasis 1 In conclusion, the miRLXR-alpha/PPAR-gamma axis modulates the proliferation of keratinocytes and might be a novel target for psoriasis treatment, which needs further in vivo investigation. +other 32594381 hsa-mir-137 Facial Nerve Injuries We recently reported the neuroprotective effect of miR3p for brachial plexus avulsion-induced motoneuron death. +other 32594381 hsa-mir-137 Neurotoxicity Syndromes The present study is sought to investigate whether miR3p also could protect PC12 cells against hydrogen peroxide (H(2)O(2)) induced neurotoxicity. +transcription factor target 32594381 hsa-mir-137 Neurodegenerative Diseases Collectively, these findings highlight the neuroprotective role of miR3p through down-regulating calpain and NOS activity, suggesting its potential role for combating oxidative stress insults in the neurodegenerative diseases. +lncRNA target 32593718 hsa-mir-34a Atherosclerosis However, inhibition of the miR-34a abolished these effects of IS in vitro, indicating that miR-34a is involved in the development of AS induced by IS. +lncRNA target 32593682 hsa-mir-27a Carcinoma, Hepatocellular CONCLUSIONS: Maternal obesity plays a role in regulating cumulative susceptibility to HCC development in offspring over multiple generations through the miR-27a-3p-Acsl1/Aldh2 axis. In this study, we identified a microRNA (miR-27a-3p) that was upregulated in obese mothers and could be passed on to their offspring. +lncRNA target 32593682 hsa-mir-27a Obesity, Maternal CONCLUSIONS: Maternal obesity plays a role in regulating cumulative susceptibility to HCC development in offspring over multiple generations through the miR-27a-3p-Acsl1/Aldh2 axis. In this study, we identified a microRNA (miR-27a-3p) that was upregulated in obese mothers and could be passed on to their offspring. +lncRNA target 32593559 hsa-mir-223 Hypertension, Pulmonary The modification of microRNAassociated downstream signaling through ProT transduction may play an important role in mitigating cardiopulmonary remodeling in flow-induced PH. +genetics_GWAS 32593310 hsa-mir-9 Thyroid Cancer, Papillary This study investigated the association of B-type RAF kinase (BRAF)(V600E) mutation status, the expression of BRAF-activated long non-coding RNA (BANCR) and microRNA miR-9, and the clinicopathological features of papillary thyroid carcinoma (PTC). PTC patients with these clinicopathological characteristics, BRAFV600E mutation, and high BANCR expression and low miR-9 expression needed earlier surgical treatment and are recommended for total thyroidectomy in primary surgery for reducing the risk of recurrence. +lncRNA target 32593303 hsa-mir-449c Carcinoma, Hepatocellular Moreover, circUHRF1 inhibits NK cell function by upregulating the expression of TIM-3 via degradation of miR-449c-5p. +other 32593198 hsa-mir-204 Angelman Syndrome In the current study, the mechanism driving the effects of C3G on AS rabbits and injured ECs were explored by focusing on the changes in miR5p/SIRT1 axis. +lncRNA target 32592723 hsa-mir-424 Osteosarcoma 5p in osteosarcoma inhibiting VEGFA. +genetics_overexpression_promote 32592428 hsa-mir-188 Lung Neoplasms We also identified MDK as a target of miR-188, and overexpression of MDK was found in lung cancer samples. +genetics_GWAS 32592422 hsa-mir-33a Scleroderma, Systemic CONCLUSION: DKK-1 is reduced in SSc cells and is regulated by miR33a-3p, and restoring DKK-1 levels through epigenetic means could be a therapeutic target in systemic sclerosis. +lncRNA target 32592373 hsa-mir-7 Sarcoma 37 RESULTS: We showed that miRNA-7 markedly inhibited the expression of EGFR and decreased the growth of glioblastoma cells, relative to blank control and negative control miRNA (p < 0.05). +circulation_biomarker_prognosis_down 32592365 hsa-mir-576 Colorectal Neoplasms 3p and miR-613 in addition to YKL40 serum levels determinations may help in the diagnosis of CRC. +circulation_biomarker_prognosis_down 32592365 hsa-mir-613 Colorectal Neoplasms 3p and miR-613 in addition to YKL40 serum levels determinations may help in the diagnosis of CRC. +genetics_GWAS 32592352 hsa-mir-146c Breast Neoplasms CONCLUSION: Overall, our results indicated no correlation between miR-146a G/C (rs2910164) polymorphism and genetic susceptibility to breast cancer in Iranian female populations. +genetics_GWAS 32592352 hsa-mir-146a Breast Neoplasms CONCLUSION: Overall, our results indicated no correlation between miR-146a G/C (rs2910164) polymorphism and genetic susceptibility to breast cancer in Iranian female populations. +other 32592277 hsa-mir-1 Colorectal Neoplasms 5p, hsa-miRNA-206 and hsa-let-7a-5p) that are closely associated with colorectal carcinogenesis in 40 conventional adenomas (tubular and tubulovillous adenomas), 20 intramucosal carcinomas (IMCs) and 60 invasive colorectal cancers (iCRCs) using reverse-transcription polymerase chain reaction. +other 32592277 hsa-mir-21 Colorectal Neoplasms 5p, hsa-miRNA-206 and hsa-let-7a-5p) that are closely associated with colorectal carcinogenesis in 40 conventional adenomas (tubular and tubulovillous adenomas), 20 intramucosal carcinomas (IMCs) and 60 invasive colorectal cancers (iCRCs) using reverse-transcription polymerase chain reaction. +other 32592277 hsa-let-7a Colorectal Neoplasms 5p, hsa-miRNA-206 and hsa-let-7a-5p) that are closely associated with colorectal carcinogenesis in 40 conventional adenomas (tubular and tubulovillous adenomas), 20 intramucosal carcinomas (IMCs) and 60 invasive colorectal cancers (iCRCs) using reverse-transcription polymerase chain reaction. +other 32592277 hsa-mir-191 Colorectal Neoplasms 5p, hsa-miRNA-206 and hsa-let-7a-5p) that are closely associated with colorectal carcinogenesis in 40 conventional adenomas (tubular and tubulovillous adenomas), 20 intramucosal carcinomas (IMCs) and 60 invasive colorectal cancers (iCRCs) using reverse-transcription polymerase chain reaction. +other 32592277 hsa-mir-27a Colorectal Neoplasms 5p, hsa-miRNA-206 and hsa-let-7a-5p) that are closely associated with colorectal carcinogenesis in 40 conventional adenomas (tubular and tubulovillous adenomas), 20 intramucosal carcinomas (IMCs) and 60 invasive colorectal cancers (iCRCs) using reverse-transcription polymerase chain reaction. +other 32592277 hsa-mir-27b Colorectal Neoplasms 5p, hsa-miRNA-206 and hsa-let-7a-5p) that are closely associated with colorectal carcinogenesis in 40 conventional adenomas (tubular and tubulovillous adenomas), 20 intramucosal carcinomas (IMCs) and 60 invasive colorectal cancers (iCRCs) using reverse-transcription polymerase chain reaction. +other 32592277 hsa-mir-125b Colorectal Neoplasms 3p and hsa-miRNA-206, are candidate markers that play critical roles in the progression of IMC to iCRC. +other 32592277 hsa-mir-34b Colorectal Neoplasms 5p, hsa-miRNA-206 and hsa-let-7a-5p) that are closely associated with colorectal carcinogenesis in 40 conventional adenomas (tubular and tubulovillous adenomas), 20 intramucosal carcinomas (IMCs) and 60 invasive colorectal cancers (iCRCs) using reverse-transcription polymerase chain reaction. +other 32592277 hsa-mir-143 Colorectal Neoplasms 3p and hsa-miRNA-206, are candidate markers that play critical roles in the progression of IMC to iCRC. +other 32592277 hsa-mir-206 Colorectal Neoplasms 3p and hsa-miRNA-206, are candidate markers that play critical roles in the progression of IMC to iCRC. +other 32592277 hsa-mir-193b Colorectal Neoplasms 5p, hsa-miRNA-206 and hsa-let-7a-5p) that are closely associated with colorectal carcinogenesis in 40 conventional adenomas (tubular and tubulovillous adenomas), 20 intramucosal carcinomas (IMCs) and 60 invasive colorectal cancers (iCRCs) using reverse-transcription polymerase chain reaction. +other 32592277 hsa-mir-19a Colorectal Neoplasms 5p, hsa-miRNA-206 and hsa-let-7a-5p) that are closely associated with colorectal carcinogenesis in 40 conventional adenomas (tubular and tubulovillous adenomas), 20 intramucosal carcinomas (IMCs) and 60 invasive colorectal cancers (iCRCs) using reverse-transcription polymerase chain reaction. +other 32592222 hsa-mir-146b Uterine Cervical Neoplasms In conclusion, circ_0000520 repressed CC progression in vitro and in vivo by sponging miR-146b-3p to release PAX5. +lncRNA target 32592206 hsa-mir-10b Carcinoma, Pancreatic Ductal CONCLUSION: Our results suggest that miR-10b could inhibit the progression of PDAC by regulating E2F7 expression and acts as an independent prognostic risk factor for PDAC. +lncRNA target 32592202 hsa-mir-197 Stomach Neoplasms Hsa_circ_001988 inhibits the proliferation and metastasis of GC via modulating EIF4A3/U2AF65-mediated hsa_circ_001988/miR +genetics_overexpression_promote 32592199 hsa-mir-489 Leukemia, Myeloid, Acute 3p overexpression restricted AML cell growth, and SRY-related high-mobility-group box 12 (SOX12) was identified as a miR +circulation_biomarker_diagnosis_up 32591941 hsa-mir-497 Pneumonia, Bacterial Serum miR +genetics_overexpression_promote 32591615 hsa-mir-200b Carcinoma, Hepatocellular Exosomes isolated from HCC culture supernatants with miR-200b-3p overexpression suppressed endothelial ERG expression. +circulation_biomarker_diagnosis_ns 32591511 hsa-mir-181a Gastrointestinal Diseases Here we report that miR-181a is able to transform fallopian tube secretory epithelial cells through the inhibition of RB1 and stimulator-of-interferon-genes (STING) to propagate cells with a high degree of GI. MiR-181a targeting of RB1 leads to profound nuclear defects and GI generating aberrant cytoplasmic DNA, however simultaneous miR-181a mediated inhibition of STING allows cells to bypass interferon mediated cell death. +exosome 32590883 hsa-mir-221 Carcinoma, Ovarian Epithelial These observations suggest that TAMs-derived exosomal miR +genetics_GWAS 32590820 hsa-mir-340 Cardiomegaly 3p levels were positively correlated with S100B levels in the control subjects and patients with ICM and DCM.The S100B rs9722 locus SNP is associated with CHF risk in a Chinese Han population. +other 32590607 hsa-mir-548b Osteoarthropathy, Primary Hypertrophic Validation using quantitative polymerase chain reaction showed significant upregulation of miR-17 and miR548b after CI/EVR. We found that miR-17 and miR-548b were upregulated in alveolar epithelial cells after CI/EVR, which merit further exploration. +other 32590607 hsa-mir-548b Exudative Vitreoretinopathy 4 Validation using quantitative polymerase chain reaction showed significant upregulation of miR-17 and miR548b after CI/EVR. We found that miR-17 and miR-548b were upregulated in alveolar epithelial cells after CI/EVR, which merit further exploration. +other 32590607 hsa-mir-17 Osteoarthropathy, Primary Hypertrophic Validation using quantitative polymerase chain reaction showed significant upregulation of miR-17 and miR548b after CI/EVR. We found that miR-17 and miR-548b were upregulated in alveolar epithelial cells after CI/EVR, which merit further exploration. +other 32590607 hsa-mir-17 Exudative Vitreoretinopathy 4 Validation using quantitative polymerase chain reaction showed significant upregulation of miR-17 and miR548b after CI/EVR. We found that miR-17 and miR-548b were upregulated in alveolar epithelial cells after CI/EVR, which merit further exploration. +transcription factor target 32590607 hsa-mir-17 Lung Injury Downstream analysis identified abundant inflammatory and immunologic targets for miR-17 and miR-548b that are known mediators of lung injury. +transcription factor target 32590607 hsa-mir-548b Lung Injury Downstream analysis identified abundant inflammatory and immunologic targets for miR-17 and miR-548b that are known mediators of lung injury. +other 32590403 hsa-mir-682 Myocardial Reperfusion Injury Therefore, the Gm4419/miR-682/TRAF3 axis may be an important regulatory mechanism in myocardial ischemia/reperfusion injury. +circulation_biomarker_diagnosis_ns 32590288 hsa-mir-434 Sarcoma, Ewing Of these, miR3p and miR-133a-3p were observed to have greatest changes in both blood and brain of SE animals. +circulation_biomarker_diagnosis_ns 32590288 hsa-mir-133a Sarcoma, Ewing Of these, miR3p and miR-133a-3p were observed to have greatest changes in both blood and brain of SE animals. +other 32590190 hsa-mir-485 Carcinoma, Non-Small-Cell Lung In conclusion, we proved that SPI1/SNHG6/miR3p/VPS45 axis exerted oncogenic role in the cellular process of NSCLC cells. +lncRNA target 32589479 hsa-mir-137 Carcinoma, Hepatocellular TUG1 targeted miR-137 and the two was negatively correlated, and silencing TUG1 expression inhibited the effects of low-expressed miR-137 on promoting proliferation, migration, and invasion of hepatoma cells. +other 32589477 hsa-mir-504 Uterine Cervical Neoplasms Cell cycle, DNA replication, and p53 signaling pathway were important mechanisms of downregulated hsa-miR-504 involved in the occurrence and development of cervical cancer. +circulation_biomarker_prognosis_ns 32589328 hsa-mir-766 Esophageal Squamous Cell Carcinoma Therefore, serum exosomal miR +other 32588875 hsa-mir-223 Carcinoma, Renal Cell 3p and subsequently increasing FBXW7 expression. +lncRNA target 32588766 hsa-mir-590 Pancreatic Carcinoma MicroRNA-590 can inhibit cell proliferation and induce cell apoptosis in pancreatic ductal adenocarcinoma cells. +genetics_knock down_promote 32588752 hsa-mir-222 Carcinoma, Non-Small-Cell Lung 3p, and its knockdown weakened the regulatory effect of microRNA +transcription factor target 32588739 hsa-mir-185 Colorectal Neoplasms 3p was low-expressed in CRC tissues and 5-FU-resistance cells, and it targeted and regulated the expression of AQP5, which was found up-regulated in CRC and 5-FU-resistance CRC cells (r = -0.29, P < .05). +lncRNA target 32588730 hsa-mir-145 Ovarian Neoplasms Hsa_circ_0009910, representing unfavorable prognosis, induced proliferative and motile phenotypes by suppressing miR-145 in ovarian cancer cells. +circulation_biomarker_prognosis_ns 32588541 hsa-mir-500a Stomach Neoplasms Furthermore, elevated miR-500a-3p in the plasma exosomes of GC patients is correlated with DDP resistance and thereby results in poor progression-free prognosis. +genetics_GWAS 32587835 hsa-mir-155 Pre-Eclampsia We aimed to investigate for the first time the association of mir-155rs767649 polymorphism with PE. +other 32587801 hsa-mir-145 Precursor Cell Lymphoblastic Leukemia-Lymphoma The expression levels of miR-145 in ALL children were decreased and they were associated with disease prognosis. The data indicated that miR-145 can reverse cell resistance by regulating apoptosis of CEM-C1 cells and autophagy. +genetics_knock down_promote 32587662 hsa-mir-155 Fibrosis, Renal 5p knockdown significantly blocks renal fibrosis both in vivo and in vitro. +other 32587612 hsa-mir-7 Fibrosis FGFR4 was downregulated, but miR5p was markedly enhanced in the liver samples as the degree of liver fibrosis rose. +transcription factor target 32587563 hsa-mir-339 Ischemic Stroke In summary, these findings suggested that miR-339 might act as a disruptive molecule to accelerate the IS progression via targeting the FGF9/CACNG2 axis and mediating the MAPK pathway. +other 32587479 hsa-mir-141 Stomach Neoplasms Activation of the LINC00242/miR-141/FOXC1 axis underpins the development of gastric cancer. +circRNA target 32587447 hsa-mir-130a Crohn Disease CONCLUSION: Hsa_circRNA_102610 upregulation in CD patients could promote the proliferation and EMT of intestinal epithelial cells via sponging of hsa-miR-130a-3p. +exosome 32587378 hsa-mir-92a-2 Liver Neoplasms Together, these findings suggest that macrophages in the liver cancer tumor microenvironment may function via exosomes to regulate liver cancer progression, and targeting this newly identified macrophages/exosomes-miR-92a +other 32587254 hsa-mir-200b Primary Graft Dysfunction In a rat small bowel transplantation model of allograft rejection treated with HO-1/BMMSCs, we confirmed that the level of miR-200b in the transplanted small bowel tissue was increased significantly, while the level of HMGB3/JNK was downregulated significantly. +genetics_knock down_suppress 32587254 hsa-mir-200b Inflammation Functional experiments confirmed that miR-200b overexpression could reduce the inflammatory injury of IEC-6s, while intracellular miR-200b knockdown could significantly block the protective effect of HO-1/BMMSCs exosomes on the inflammatory injury of IEC-6s. The mechanism is related to miR-200b targeting the abnormally increased expression of the Hmgb3 gene in IECs induced by inflammatory injury. +other 32587240 hsa-mir-494 Pre-Eclampsia In conclusion, trophoblast cell migration and invasion were shown to be promoted and modulated by the hsa_circ_0111277/miR3p/HTRA1/Notch-1 axis, which provides useful insight for exploring a new therapeutic approach for PE. +other 32586906 hsa-mir-146a Thrombosis Low levels of miR-146a, a brake of inflammatory response, are involved in higher risk for cardiovascular events, but the mechanisms explaining how miR-146a exerts its function remain largely undefined. Furthermore, we demonstrated that community acquired pneumonia (CAP) patients with reduced miR-146a levels associated with the T variant of the functional rs2431697, presented an increased risk for cardiovascular events due in part to an increased generation of NETs. +genetics_knock down_suppress 32586280 hsa-mir-34c Nasopharyngeal Carcinoma Two human normal nasopharyngeal cell lines (immortalized; NP69 and NP460), as well as the NPC cell line C666-1, were used for miR-34c gain-of-function and loss-of-function experiments. +lncRNA target 32586178 hsa-mir-199a Diabetic Retinopathy CONCLUSION: Our findings revealed that in the DR rat model, miR-199a-3p inhibited cell proliferation, migration, and invasion of EC and RP through targeting FGF7 and inhibiting the activation of the EGFR/PI3K/AKT pathway. +genetics_overexpression_promote 32586155 hsa-mir-363 Esophageal Squamous Cell Carcinoma miR-363 overexpression decreased ESCC cell proliferation and invasion and increased apoptosis, while the opposite was seen after miR-363 inhibition. +other 32585876 hsa-mir-34a Ventricular Premature Complexes Hence, the vascular age-associated miR-34a promotes VSMCs SASP activation and contributes to arterial inflammation and dysfunctions such as VC. +other 32585876 hsa-mir-34a Vascular Diseases MicroRNA-34a (miR-34a) is a driver of such phenomena and could play a role in vascular inflammaging. +other 32585876 hsa-mir-34a Arteritis Hence, the vascular age-associated miR-34a promotes VSMCs SASP activation and contributes to arterial inflammation and dysfunctions such as VC. +other 32585840 hsa-mir-155 Parkinson Disease In addition, miR-155 was upregulated in LRRK2-PD compared to iPD patients showing an appropriate value of area under the ROC curve (AUC 0.80) to discriminate between the two groups. +genetics_overexpression_promote 32585676 hsa-mir-25 Fetal Growth Retardation CONCLUSIONS: FGR fetuses express a different miRNA profile, which includes overexpression of miR +genetics_overexpression_promote 32585676 hsa-mir-148b Fetal Growth Retardation CONCLUSIONS: FGR fetuses express a different miRNA profile, which includes overexpression of miR +lncRNA target 32585626 hsa-mir-200b Breast Neoplasms Our further experiments found that H19 might regulate SP1-TGFBR2 through let-7b and miR-200b, ETS1-TGFBR2 through miR-29a and miR-200b, and STAT3-KLF11 through miR-17 in breast cancer cell lines. +lncRNA target 32585626 hsa-let-7b Breast Neoplasms Our further experiments found that H19 might regulate SP1-TGFBR2 through let-7b and miR-200b, ETS1-TGFBR2 through miR-29a and miR-200b, and STAT3-KLF11 through miR-17 in breast cancer cell lines. +lncRNA target 32585626 hsa-mir-17 Breast Neoplasms Our further experiments found that H19 might regulate SP1-TGFBR2 through let-7b and miR-200b, ETS1-TGFBR2 through miR-29a and miR-200b, and STAT3-KLF11 through miR-17 in breast cancer cell lines. +genetics_knock down_suppress 32585604 hsa-mir-345 Rhinitis, Allergic 5p in AR was determined using gain- and loss-of-function approaches. +other 32585557 hsa-let-7i Laryngeal Neoplasms Expression of let-7i and miR-192 is associated with resistance to cisplatin-based chemoradiotherapy in patients with larynx and hypopharynx cancer. +other 32585557 hsa-mir-192 Laryngeal Neoplasms Expression of let-7i and miR-192 is associated with resistance to cisplatin-based chemoradiotherapy in patients with larynx and hypopharynx cancer. +other 32585423 hsa-mir-197 Meningioma Quercetin may reduce meningioma cell proliferation and increase apoptosis by activating the miR-197/IGFBP5 cascade and regulating Bcl-2/Bax. +exosome 32585413 hsa-mir-5703 Pancreatic Carcinoma Furthermore, we identified that miR-5703 in the exosomes acted as a driver of cell proliferation and its inhibitor suppressed the function of exosomes to promote PC cell proliferation. In conclusion, our results suggest that PSC-derived exosomal miR-5703 could target CMTM4 in PC cells and promote cell proliferation due to PAK4 activated PI3K/Akt pathway. +transcription factor target 32585247 hsa-mir-18a Pulmonary Arterial Hypertension CONCLUSIONS: Collectively, this study identified the up-regulated miR-18a-5p in the PAH patients; our data suggest that miR-18a-5p contributes to the enhanced proliferation and migration of PASMCs via repressing Notch2 expression. +lncRNA target 32585241 hsa-mir-129 Glioblastoma SIGNIFICANCE: FGD5-AS1 promoted GBM progression at least partly by regulating miR5p/HNRNPK to activate Wnt/beta-catenin signaling, suggesting the potential of FGD5-AS1 as a candidate target to improve GBM therapy. +genetics_overexpression_promote 32585234 hsa-mir-4769 Nasopharyngeal Carcinoma 5p overexpression. +other 32585234 hsa-mir-4769 Intervertebral disc disease LncRNA TRPC7-AS1, miR5p, and Hepsin (HPN) may form a lncRNA-miRNA-mRNA network that can regulate NPC proliferation, senescence and ECM in IDD. +other 32584920 hsa-mir-296 Acquired Immunodeficiency Syndrome The decreased expression of miR5p found in naive patients with HIV infection suggests a regulatory activity of this miRNA on virus replication, making it a potential therapeutic agent against HIV. +other 32584915 hsa-mir-184 Bacterial Infections We further revealed the JNK pathway is regulated by microRNA-184 in response to bacterial infection. +lncRNA target 32584521 hsa-mir-181c von Hippel-Lindau Disease We further found that miR-181c suppressed the expression of von Hippel-Lindau (VHL), while circPDE4B could promote VHL expression via binding to miR-181c. In conclusion, circPDE4B suppressed the expression of VEGFA and pathological angiogenesis via promoting VHL-mediated ubiquitin degradation of HIF-1alpha through binding to miR-181c. +lncRNA target 32584497 hsa-mir-124 Thyroid Neoplasms Here, we aimed to ascertain the role of circDOCK1-miR-124 node in thyroid cancer cells. CONCLUSION: circDOCK1 contributed to thyroid carcinogenesis through inhibition of miR-124 in thyroid cancer cells with dampening signaling transduction of JAK/STAT/AMPK in virtue of miR-124 downregulation. +transcription factor target 32584470 hsa-mir-877 Osteoarthritis 5p could inhibit IL-1beta-induced inflammation in both in vitro and in vivo models of OA. +other 32584170 hsa-mir-29c Osteosarcoma Among these genes, BVES and PSMB2 presented a high expression level in osteosarcoma based on GSE99671 and GSE87624 data sets, while miR-29c showed a low expression level in osteosarcoma based on GSE65071 and GSE28423 data sets. +exosome 32583714 hsa-mir-130a Crohn Disease Inhibition of these miRNAs in exosome-donor cells infected with AIEC LF82 abolished the increase in miR-30c and miR-130a levels in the released Exo-LF82 and in Exo-LF82-receiving cells, thus suppressing the inhibitory effect of Exo-LF82 on ATG5 and ATG16L1 expression and on autophagy-mediated AIEC clearance in Exo-LF82-receiving cells. +transcription factor target 32583575 hsa-mir-620 Asthma These findings suggest that miR-620/PTEN/AKT axis may be considered as a therapeutic target for asthma treatment. +lncRNA target 32583510 hsa-mir-146a Pulmonary Disease, Chronic Obstructive CONCLUSION: LncRNA MALAT1 exhibits clinical implications in acute exacerbation risk prediction and management of COPD via the inner-correlation with its targets miR-125b, miR-146a, and miR-203. +other 32583510 hsa-mir-125b Pulmonary Disease, Chronic Obstructive Besides, lncRNA MALAT1 negatively correlated with miR-125b, miR-146a, and miR-203 in AECOPD patients and reversely correlated with miR-125b and miR-146a in stable COPD patients. Notably, miR-125b, miR-133, miR-146a, and miR-203 were the lowest in AECOPD patients, followed by stable COPD patients, and then HCs; miR-125b, miR-133, miR-146a, and miR-203 negatively correlated with inflammation and GOLD stage in AECOPD and stable COPD patients. +lncRNA target 32583510 hsa-mir-203 Pulmonary Disease, Chronic Obstructive CONCLUSION: LncRNA MALAT1 exhibits clinical implications in acute exacerbation risk prediction and management of COPD via the inner-correlation with its targets miR-125b, miR-146a, and miR-203. +target gene 32583487 hsa-mir-152 Acute Kidney Injury miR-152-3p could promote the expression of STAT3 by targeting ERRFI1, aggravate cell apoptosis and inflammatory response, and thereby aggravate kidney injury in sepsis AKI. +lncRNA target 32583462 hsa-mir-30 Lung Neoplasms Stable restoration of reduced miR-330 expression in lung cancer cells reduces cell viability, increases the fraction of apoptotic cells, causes G2/M cell cycle arrest, and inhibits cell migration. +circulation_biomarker_diagnosis_down 32583425 hsa-mir-423 Carcinoma, Renal Cell Of importance, LINC01426 was certified to distribute both in the cytoplasm and the nucleus of ccRCC cells, and it increased CTBP1 expression through recruiting insulin like growth factor 2 mRNA binding protein 1 (IGF2BP1) in cytoplasm whereas interacted with CTBP1 protein to improve the transcriptional repression on miR +other 32583363 hsa-let-7a hereditary diffuse gastric cancer PURPOSE: Analyze the expression of caspase-9, Smac/DIABLO, XIAP, let-7a, and let-7b in patients with normal gastric tissue, chronic gastritis, and gastric adenocarcinoma. METHODS: The expression of caspase-9, Smac/DIABLO, XIAP, let-7a, and let-7b by qRT-PCR was analyzed in 158 samples from 53 patients with normal gastric mucosa, 86 with chronic gastritis, and 19 with gastric cancer. +other 32583363 hsa-let-7b Gastritis, Atrophic PURPOSE: Analyze the expression of caspase-9, Smac/DIABLO, XIAP, let-7a, and let-7b in patients with normal gastric tissue, chronic gastritis, and gastric adenocarcinoma. METHODS: The expression of caspase-9, Smac/DIABLO, XIAP, let-7a, and let-7b by qRT-PCR was analyzed in 158 samples from 53 patients with normal gastric mucosa, 86 with chronic gastritis, and 19 with gastric cancer. +other 32583363 hsa-let-7b hereditary diffuse gastric cancer PURPOSE: Analyze the expression of caspase-9, Smac/DIABLO, XIAP, let-7a, and let-7b in patients with normal gastric tissue, chronic gastritis, and gastric adenocarcinoma. METHODS: The expression of caspase-9, Smac/DIABLO, XIAP, let-7a, and let-7b by qRT-PCR was analyzed in 158 samples from 53 patients with normal gastric mucosa, 86 with chronic gastritis, and 19 with gastric cancer. +other 32583363 hsa-let-7a Gastritis, Atrophic PURPOSE: Analyze the expression of caspase-9, Smac/DIABLO, XIAP, let-7a, and let-7b in patients with normal gastric tissue, chronic gastritis, and gastric adenocarcinoma. METHODS: The expression of caspase-9, Smac/DIABLO, XIAP, let-7a, and let-7b by qRT-PCR was analyzed in 158 samples from 53 patients with normal gastric mucosa, 86 with chronic gastritis, and 19 with gastric cancer. +other 32583195 hsa-mir-98 Triple Negative Breast Neoplasms CONCLUSIONS: We developed a prediction model consisting of miR-98, tumor size, and LVI for SLNM with high accuracy in ER+/HER2- breast cancer. +lncRNA target 32583079 hsa-mir-1277 Stomach Neoplasms 5p and upregulating COL5A1, and COL5A1-mediated GC cell proliferation may be mediated by effects on the tumor microenvironment, which provides novel targets for GC treatment. +lncRNA target 32582989 hsa-mir-23a Stomach Neoplasms The results of the present study demonstrated that miR23a3p inhibited proliferation and induced apoptosis of GC cells, which may be attributable to its direct targeting of BCL2. +other 32582988 hsa-mir-135a Neuralgia Using bioinformatics analyses, luciferase reporter assays, and a series of behavioral tests, it was demonstrated that the decrease in SLC24A2 after CCI treatment was directly regulated by increased microRNA (miR)135a5p in the spinal cord. +lncRNA target 32582987 hsa-mir-375 Neurotoxicity Syndromes MicroRNA375 (miR375) was initially identified as a tumorsuppressive factor, and its expression was negatively associated with the severity of lung cancer; however, its role and potential mechanism in myofibroblast transdifferentiation and pulmonary fibrosis remain unclear. +lncRNA target 32582987 hsa-mir-375 Pulmonary Fibrosis MicroRNA375 (miR375) was initially identified as a tumorsuppressive factor, and its expression was negatively associated with the severity of lung cancer; however, its role and potential mechanism in myofibroblast transdifferentiation and pulmonary fibrosis remain unclear. In conclusion, miR375 was implicated in modulating TGFbetadependent transdifferentiation of lung fibroblasts, and targeting miR375 expression may help to develop therapeutic approaches for treating pulmonary fibrosis. +lncRNA target 32582987 hsa-mir-375 Lung Neoplasms MicroRNA375 (miR375) was initially identified as a tumorsuppressive factor, and its expression was negatively associated with the severity of lung cancer; however, its role and potential mechanism in myofibroblast transdifferentiation and pulmonary fibrosis remain unclear. +lncRNA target 32582976 hsa-mir-148a Liver Cirrhosis, Alcoholic These data suggested that miR148a3p regulated ALF and the viability and apoptosis of hepatic stellate cells through targeting ERBB3. +lncRNA target 32582975 hsa-mir-202 Multiple Sclerosis Therefore, the miR2023p/betacatenin/Gli1 axis may be of value as a therapeutic target in multiple sclerosis. +transcription factor target 32582975 hsa-mir-202 high grade glioma Therefore, the present study was designed to investigate whether IL1beta modifies the proliferation and differentiation of oligodendrocyte precursor cells (OPCs) through regulating the miR2023p/betacatenin/gliomaassociated oncogene homolog 1 (Gli1) axis. +genetics_overexpression_promote 32582971 hsa-mir-802 Uterine Cervical Neoplasms Decreased expression levels of miR802 were found in cervical cancer tissues and cells, and the overexpression of miR802 inhibited cell viability, migration and invasion. +transcription factor target 32582959 hsa-mir-103 Carcinoma, Non-Small-Cell Lung Collectively, the current results demonstrated that miR103 serves a tumorigenesis role in NSCLC development by targeting KLF7, at least partly via the Wnt/betacatenin signaling pathway. +circulation_biomarker_prognosis_ns 32582802 hsa-mir-18a Multiple Sclerosis Altered signaling plays an important role in MS pathogenesis and the miR-18a-5p expression profile in blood cells can be described as a prognostic biomarker and identifier of high-risk individuals in MS. +circulation_biomarker_diagnosis_up 32582793 hsa-mir-24 Precursor Cell Lymphoblastic Leukemia-Lymphoma Nevertheless, no statistically significant associations were seen between miR-24 levels and plasma MTX levels 48 h after HD-MTX administration (p > 0.05) or EFS in pediatric ALL patients (p > 0.05). +target gene 32582765 hsa-mir-362 Uterine Cervical Neoplasms MicroRNA-362-3p Inhibits Migration and Invasion via Targeting BCAP31 in Cervical Cancer. +lncRNA target 32582694 hsa-mir-671 pancreatic adenocarcinoma MATERIALS AND METHODS: starBase database was used to perform differential expression, survival, and competing endogenous RNA (ceRNA) network and H19/miR-671 correlation analyses for CASC8 in 178 PAAD samples. CONCLUSION: CASC8 is specifically expressed at a high level in PAAD and associated with poor prognosis, which might be through its interaction with H19, miR-671, and SMAD7. +other 32582347 hsa-mir-103 Colorectal Neoplasms Moreover, miR107 was upregulated in CRC tissues compared with paired normal tissues (2.1 /- 1.4 vs. 1.25 /- 0.83, P = 0.005), while NKILA displayed an opposite expression pattern versus miR103/107, but it was not statistically significant (3.69 /- 5.2 vs. 4.35 /- 5.99, P > 0.05). +other 32582275 hsa-mir-3677 Colonic Neoplasms Next, we developed an 8-miRNA (hsa-mir-6854, hsa-mir-4437, hsa-mir-216a, hsa-mir-3677, hsa-mir-887, hsa-mir-4999, hsa-mir-34b, and hsa-mir-3189) prognostic signature for patients with colon cancer by Cox proportional hazards regression analysis. +other 32582275 hsa-mir-887 Colonic Neoplasms Next, we developed an 8-miRNA (hsa-mir-6854, hsa-mir-4437, hsa-mir-216a, hsa-mir-3677, hsa-mir-887, hsa-mir-4999, hsa-mir-34b, and hsa-mir-3189) prognostic signature for patients with colon cancer by Cox proportional hazards regression analysis. +other 32582275 hsa-mir-189 Colonic Neoplasms Next, we developed an 8-miRNA (hsa-mir-6854, hsa-mir-4437, hsa-mir-216a, hsa-mir-3677, hsa-mir-887, hsa-mir-4999, hsa-mir-34b, and hsa-mir-3189) prognostic signature for patients with colon cancer by Cox proportional hazards regression analysis. +other 32582275 hsa-mir-216a Colonic Neoplasms Next, we developed an 8-miRNA (hsa-mir-6854, hsa-mir-4437, hsa-mir-216a, hsa-mir-3677, hsa-mir-887, hsa-mir-4999, hsa-mir-34b, and hsa-mir-3189) prognostic signature for patients with colon cancer by Cox proportional hazards regression analysis. +other 32582275 hsa-mir-34b Colonic Neoplasms Next, we developed an 8-miRNA (hsa-mir-6854, hsa-mir-4437, hsa-mir-216a, hsa-mir-3677, hsa-mir-887, hsa-mir-4999, hsa-mir-34b, and hsa-mir-3189) prognostic signature for patients with colon cancer by Cox proportional hazards regression analysis. +other 32582275 hsa-mir-6854 Colonic Neoplasms Next, we developed an 8-miRNA (hsa-mir-6854, hsa-mir-4437, hsa-mir-216a, hsa-mir-3677, hsa-mir-887, hsa-mir-4999, hsa-mir-34b, and hsa-mir-3189) prognostic signature for patients with colon cancer by Cox proportional hazards regression analysis. +other 32582275 hsa-mir-4437 Colonic Neoplasms Next, we developed an 8-miRNA (hsa-mir-6854, hsa-mir-4437, hsa-mir-216a, hsa-mir-3677, hsa-mir-887, hsa-mir-4999, hsa-mir-34b, and hsa-mir-3189) prognostic signature for patients with colon cancer by Cox proportional hazards regression analysis. +other 32582275 hsa-mir-4999 Colonic Neoplasms Next, we developed an 8-miRNA (hsa-mir-6854, hsa-mir-4437, hsa-mir-216a, hsa-mir-3677, hsa-mir-887, hsa-mir-4999, hsa-mir-34b, and hsa-mir-3189) prognostic signature for patients with colon cancer by Cox proportional hazards regression analysis. +other 32582027 hsa-mir-7g ACTH Syndrome, Ectopic undetectable levels in EAS, P = 0.008; q = 0.087] and differences in miR-7g-5p [1.842 (1.283-2.400) in CD vs. +other 32582027 hsa-mir-145 ACTH Syndrome, Ectopic 5p and miR-7g-5p are promising biomarkers for further research to differentiate ACTH-dependent CS. +other 32582027 hsa-mir-16 ACTH Syndrome, Ectopic 5p and miR-7g-5p are promising biomarkers for further research to differentiate ACTH-dependent CS. +genetics_overexpression_promote 32581828 hsa-mir-181d Microvascular Obstruction After renal IRI, miR-181d-5p overexpression significantly inhibited inflammatory mediators, reduced apoptosis and further improved renal function. +epigenetics 32581712 hsa-mir-335 Ischemic Stroke In conclusion, we found that METTL3-mediated m6A methylation increases the maturation of miR-335, which promotes SG formation and reduces the apoptosis level of injury neurons and cells, and provides a potential therapeutic strategy for AIS. +transcription factor target 32581706 hsa-mir-146a Nervous System Diseases Understanding the mechanisms by which miR-146a affects the neuroinflammatory response in different neurological injuries, different cell types, and even different stages of certain neurological diseases will pave the way for its use as a therapeutic target in neurodegenerative diseases. +other 32581651 hsa-mir-802 Stomach Neoplasms CircRNA DONSON contributes to cisplatin resistance in gastric cancer cells by regulating miR-802/BMI1 axis. +genetics_knock down_promote 32581594 hsa-mir-526b Stomach Neoplasms Furthermore, gain- and loss-of-function experiments revealed that LINC00689 promoted the proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) of GC cells, while miR-526b-3p had the opposite effects. +genetics_overexpression_promote 32581592 hsa-mir-233 Carcinoma, Squamous Cell, Cutaneous In CSCC cells, overexpression of MAGI2-AS3 led to upregulated, while overexpression of miRNA-233 led to downregulated expression of EPB41L3. +genetics_overexpression_promote 32581592 hsa-mir-233 Uterine Cervical Neoplasms In CSCC cells, overexpression of MAGI2-AS3 led to upregulated, while overexpression of miRNA-233 led to downregulated expression of EPB41L3. +circulation_biomarker_diagnosis_up 32581589 hsa-mir-625 Carcinoma, Non-Small-Cell Lung NSCLC cells were transfected with Resistin plasmids, si-Resistin plasmids, miR-625 mimics, or miR-625 inhibitors, and proliferation, invasion, and migration were determined by CCK-8, Transwell, and wound scratch assays, respectively. +other 32581581 hsa-mir-758 Breast Neoplasms LncRNA DANCR-miR-758-3p-PAX6 Molecular Network Regulates Apoptosis and Autophagy of Breast Cancer Cells. +target gene 32581560 hsa-mir-214 Breast Neoplasms lncRNA MT1JP Suppresses Biological Activities of Breast Cancer Cells in vitro and in vivo by Regulating the miRNA-214/RUNX3 Axis. +other 32581558 hsa-mir-184 Glioma By coexpression networks analysis, competing endogenous RNA (ceRNA) network analysis, cell proliferation assay and luciferase reporter assay, we confirmed that lncRNA HOXA-AS2 functioned as a ceRNA for miR-184 to regulate expression of COL6A2, which induced cell proliferation of low-grade glioma. +lncRNA target 32581554 hsa-mir-126 Colorectal Neoplasms Furthermore, CRNDE affected CRC cell progression via modulation of miR +genetics_knock down_promote 32581553 hsa-mir-142 Carcinoma, Non-Small-Cell Lung 5p restoration in NSCLC cell malignant phenotypes were attenuated by PAX6 overexpression. +genetics_GWAS 32581550 hsa-mir-326 Carcinoma, Hepatocellular Besides, the effects of miR-326 on HCC were missing when circPTN binding sites were mutated. +lncRNA target 32581548 hsa-mir-217 Carcinoma, Hepatocellular Via downregulation of miR-217, SNHG14 increased the expression of several miR +other 32581152 hsa-mir-29c Myocardial Reperfusion Injury CONCLUSIONS: This study highlighted the role of miR-29c in regulating autophagy under cardiac I/R injury, which also extended existing mechanisms of a stem cell and its derivative to explore potential therapeutic interventions in ischemic heart diseases. +circulation_biomarker_diagnosis_down 32581055 hsa-mir-25 Carcinoma, Hepatocellular CONCLUSIONS Increased serum IL-6 downregulated PTPRO expression in HCC monocytes and macrophages by activating STAT3/c-MYC/miR +virus_miRNA 32581028 ebv-mir-BART16 Infectious Mononucleosis Dynamically Expressed miR-BART16 Functions as a Suppressor of CAND1 in Infectious Mononucleosis Caused by Epstein-Barr Virus in Children +transcription factor target 32580736 hsa-mir-155 Stomach Neoplasms Then, in vitro tests shown that in addition to regulating RKIP expression via miR-27a and miR-155, Bmi-1 was also able to regulate the migration, invasion, proliferation, colony-formation ability and chemosensitivity of GC cells through the same pathway. +transcription factor target 32580736 hsa-mir-27a Stomach Neoplasms Then, in vitro tests shown that in addition to regulating RKIP expression via miR-27a and miR-155, Bmi-1 was also able to regulate the migration, invasion, proliferation, colony-formation ability and chemosensitivity of GC cells through the same pathway. +other 32580581 hsa-mir-378 Cleft Palate, Non-Syndromic CONCLUSIONS: Our findings suggest that different expression of miR-378 is consistent with the skewed sex ratio in the prevalence of NSCL/P. +genetics_knock down_suppress 32580576 hsa-mir-335 Carcinoma, Non-Small-Cell Lung CUL4B overexpression reversed the inhibitory effects on cell viability, cell cycle process, and colony formation and the promotional effect on cell apoptosis caused by miR +lncRNA target 32580513 hsa-mir-199b Rectal Neoplasms Here, we studied the functional effects of miR-199b on 5-FU sensitivity after its ectopic modulation, and its expression was quantified by real-time-PCR in a cohort of 110 LARC patients to evaluate its potential clinical significance. In conclusion, our findings highlight the clinical impact of miR-199b downregulation predicting poor outcome and pathological response in LARC, and suggest the miR-199b/SET signaling axis as a novel molecular target to prevent the development of resistance to 5-FU treatment. +transcription factor target 32580014 hsa-mir-153 Congenital central hypoventilation syndrome In vivo, the upregulation of miR-153 elicited similar reduced DRE phase and synapsin I deficiency as CCH. Our results demonstrate that CCH impairs hippocampal glutamatergic vesicle trafficking by upregulating miR-153, which suppresses the expression of synapsin I at the post-transcriptional level. +genetics_knock down_promote 32580014 hsa-mir-153 congenital myopathy 1A Further study showed an upregulated miR-153 in the hippocampus of 2VO rats. Furthermore, miR-153 knockdown rescued the downregulated synapsin I and shortened DRE phase in 2VO rats. +tissue_expression_up 32580014 hsa-mir-153 Striatonigral Degeneration In vivo, the upregulation of miR-153 elicited similar reduced DRE phase and synapsin I deficiency as CCH. +genetics_overexpression_promote 32579902 hsa-mir-410 Neurologic Manifestations 3p overexpression. +genetics_overexpression_promote 32579902 hsa-mir-410 Hypoxia-Ischemia, Brain 3p overexpression. +circulation_biomarker_diagnosis_down 32579760 hsa-mir-155 Diabetes Mellitus, Type 2 CONCLUSIONS: MicroRNA155 and microRNA29 were significantly higher in type 2 diabetes patients compared with the control patients, their levels were also positively correlated with fasting plasma glucose levels, and over-expression of microRNA155 or microRNA29 were found to downregulate glucose and lipid metabolism target genes, and reduce lipid synthesis and glucose incorporation in HepG2 cells. +circulation_biomarker_diagnosis_down 32579760 hsa-mir-29 Diabetes Mellitus, Type 2 CONCLUSIONS: MicroRNA155 and microRNA29 were significantly higher in type 2 diabetes patients compared with the control patients, their levels were also positively correlated with fasting plasma glucose levels, and over-expression of microRNA155 or microRNA29 were found to downregulate glucose and lipid metabolism target genes, and reduce lipid synthesis and glucose incorporation in HepG2 cells. +other 32579212 hsa-mir-196a Pre-Eclampsia This study supports involvement of the BHLHE40/miR-196a-5p/SNX16 axis in PE pathogenesis; Proper adjustment of the BHLHE40/miR-196a-5p/SNX16 axis is able to attenuate PE symptoms. +other 32578852 hsa-mir-30 Aortic Aneurysm, Thoracic 5p/Myh11 axis. +lncRNA target 32578777 hsa-mir-125a Glioblastoma The results suggested that miR-125a-5p might be a novel therapy target for glioblastoma. +circulation_biomarker_diagnosis_ns 32578720 hsa-mir-28 Sepsis miR-328 expression was assessed in serum of sepsis patients and in rat models of sepsis. +other 32577500 hsa-mir-16 Uterine Cervical Neoplasms miR-16-5p/PDK4-Mediated Metabolic Reprogramming Is Involved in Chemoresistance of Cervical Cancer. +other 32577165 hsa-mir-1247 Squamous Cell Carcinoma of Head and Neck 3p, and miR-181b-3p) with high accuracy in discriminating LN status, suggesting their potential application as prognostic biomarkers for nodal disease. +other 32577165 hsa-mir-107 Squamous Cell Carcinoma of Head and Neck 3p, and miR-181b-3p) with high accuracy in discriminating LN status, suggesting their potential application as prognostic biomarkers for nodal disease. +other 32577165 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck 3p, and miR-181b-3p) with high accuracy in discriminating LN status, suggesting their potential application as prognostic biomarkers for nodal disease. +other 32577165 hsa-mir-181b Squamous Cell Carcinoma of Head and Neck 3p, and miR-181b-3p) with high accuracy in discriminating LN status, suggesting their potential application as prognostic biomarkers for nodal disease. +other 32577162 hsa-mir-151a Carcinoma, Non-Small-Cell Lung We have previously established that miR-151a functions as an onco-miR in non-small cell lung cancer (NSCLC) cells by inducing partial EMT and enhancing tumor growth. Finally, we verify that miR-151a is expressed in the vasculature of normal lung and NSCLC tissue. +other 32577155 hsa-mir-128 Breast Neoplasms We found that hsa-miR-128 and hsa-miR-223 regulate genes mediating lipid signalling and cholesterol metabolism, cancer drug resistance and breast cancer genes. +other 32577155 hsa-mir-223 Breast Neoplasms We found that hsa-miR-128 and hsa-miR-223 regulate genes mediating lipid signalling and cholesterol metabolism, cancer drug resistance and breast cancer genes. +genetics_knock down_promote 32577098 hsa-mir-223 Carcinoma, Non-Small-Cell Lung The overexpression of miR-223 could inhibit the level of FBXW7 protein expression, thus promoting autophagy and making NSCLC cells resistant to cisplatin. +circRNA target 32576868 hsa-mir-337 Ischemic Stroke Collectively, our findings indicate that numerous dysregulated circRNAs may play pivotal functional roles in AIS and hsa_circ_0000607 may play a crucial role in the pathogenesis and progression of AIS by regulating the miR +other 32576230 hsa-mir-134 Neurodevelopmental Disorders At the neurobiological level, microRNAs miR-132 and miR-134 were both differentially regulated in rats and humans depending on APA. +other 32576007 hsa-mir-140 Osteoarthritis 5p regulatory axis could affect the degradation and calcification of the cartilage matrix in OA cells. +other 32575874 hsa-mir-133 Myocardial Infarction Studies have shown that microRNA-133 (miR-133) plays a positive role in the growth of cardiac myocytes, the maintenance of cardiac homeostasis, and the recovery of cardiac function, which is of great significance for the recovery of acute myocardial infarction. In summary, the delivery of miR-133 by RGD-PEG-PLA carrier can achieve cardiac lesion accumulation, thereby improving the cardiac function damage and reducing the myocardial infarction area. +transcription factor target 32575745 hsa-mir-124 Carcinoma, Hepatocellular Our results collectively indicate that LINC01488 acts as a tumor suppressor that inhibits metastasis and tumorigenesis in HCC via the miR +transcription factor target 32575745 hsa-mir-138 Carcinoma, Hepatocellular Our results collectively indicate that LINC01488 acts as a tumor suppressor that inhibits metastasis and tumorigenesis in HCC via the miR +other 32575666 hsa-mir-21 Melanoma 5p) in sEVs showing a trend of upregulation during melanoma progression. +other 32575666 hsa-mir-130a Melanoma 5p) in sEVs showing a trend of upregulation during melanoma progression. +other 32575666 hsa-mir-224 Melanoma 5p) in sEVs showing a trend of upregulation during melanoma progression. +other 32575355 hsa-mir-124 Heart Arrest Among the 673 microRNAs detected, brain-enriched miR9-3p, miR124-3p and miR129-5p positively correlated with NSE levels (all p < 0.001). +other 32575355 hsa-mir-129 Heart Arrest Among the 673 microRNAs detected, brain-enriched miR9-3p, miR124-3p and miR129-5p positively correlated with NSE levels (all p < 0.001). +other 32575162 hsa-mir-4695 Sjogren's Syndrome 3p, as well as up-regulation of TRIM21 and pro-apoptotic CASP-8 gene in pSS samples. +other 32575162 hsa-mir-1207 Sjogren's Syndrome 3p, as well as up-regulation of TRIM21 and pro-apoptotic CASP-8 gene in pSS samples. +other 32574680 hsa-mir-4331 Foot-and-Mouth Disease 5p) regulates foot and mouth virus (FMDV) replication remains unclear. +lncRNA target 32574680 hsa-mir-4331 Gastroenteritis, Transmissible, of Swine MiR-4331 aggravates transmissible gastroenteritis virus (TGEV) -induced mitochondrial damage, also suppresses transcription of TGEV gene 7 via targeting cellular CDCA7. +transcription factor target 32574680 hsa-mir-4331 Influenza, Human Otherwise, miR5p affects H1N1/2009 influenza A virus replication by targeting viral HA and NS. +other 32574667 hsa-mir-92a Optic Nerve Injuries Delivery of selected combinations of miRNAs (miR5p, miR-30c-2 and miR-92a; miR-92a, miR-292 and miR-182) before ONC provided significant therapeutic benefits according to the above measurable endpoints. +other 32574667 hsa-mir-292 Optic Nerve Injuries Delivery of selected combinations of miRNAs (miR5p, miR-30c-2 and miR-92a; miR-92a, miR-292 and miR-182) before ONC provided significant therapeutic benefits according to the above measurable endpoints. +other 32574667 hsa-mir-17 Optic Nerve Injuries Delivery of selected combinations of miRNAs (miR5p, miR-30c-2 and miR-92a; miR-92a, miR-292 and miR-182) before ONC provided significant therapeutic benefits according to the above measurable endpoints. +other 32574667 hsa-mir-182 Optic Nerve Injuries Delivery of selected combinations of miRNAs (miR5p, miR-30c-2 and miR-92a; miR-92a, miR-292 and miR-182) before ONC provided significant therapeutic benefits according to the above measurable endpoints. +other 32574204 hsa-mir-122 Hepatitis C One of the determinants for tissue tropism of hepatitis C virus (HCV) is miR-122, a liver-specific microRNA. +exosome 32574032 hsa-mir-126 Reperfusion Injury This study demonstrated that EC-Exo promoted functional motor recovery in the MCAO/R model, exosomes were critical for the reconstruction of synaptic function in ischemic brain injury, and microRNA3p from EC-Exo could serve as a treatment for nerve damage. +other 32573268 hsa-mir-155 Squamous Cell Carcinoma of Head and Neck Taken together, miR-155 could be an independent diagnostic and prognostic biomarker for ESCC. +transcription factor target 32573115 hsa-mir-182 Obesity CONCLUSIONS: Taken together, our studies identified miR-182 as a novel negative regulator of adipogenesis and a potential therapeutic target for obesity. +lncRNA target 32572927 hsa-mir-101 Sepsis OBJECTIVE: The aim of this study was to explore the effect of myocardial infarction associated transcript 2 (Mirt2) and miR-101 on sepsis-induced myocardial injury in rats and its mechanism. CONCLUSIONS: Mirt2 can silence miR-101 and inhibit myocardial inflammatory response in sepsis rats through the PI3K/AKT signaling pathway, thus improving cardiac structure and function. +lncRNA target 32572927 hsa-mir-101 Cardiomyopathies OBJECTIVE: The aim of this study was to explore the effect of myocardial infarction associated transcript 2 (Mirt2) and miR-101 on sepsis-induced myocardial injury in rats and its mechanism. CONCLUSIONS: Mirt2 can silence miR-101 and inhibit myocardial inflammatory response in sepsis rats through the PI3K/AKT signaling pathway, thus improving cardiac structure and function. +circulation_biomarker_diagnosis_ns 32572925 hsa-mir-103a-2 Esophageal Squamous Cell Carcinoma 5p demonstrated the most significant differential expression in both exosomes of ESCC cell lines and plasma of patients as compared with control patients and was therefore selected for subsequent functional experiments. +lncRNA target 32572924 hsa-mir-670 Esophageal Squamous Cell Carcinoma 3p axis may become a potential therapeutic target for ESCC therapy. +genetics_knock down_promote 32572921 hsa-mir-101 Stomach Neoplasms 3p overexpression on GCa cell migration ability and invasiveness. +genetics_overexpression_suppress 32572919 hsa-mir-34c Carcinoma, Hepatocellular Overexpression of FAM83A could reverse the inhibitory effects of miRNA-34c-5p on malignant phenotypes of HCC cells. +lncRNA target 32572916 hsa-mir-559 Carcinoma, Hepatocellular CONCLUSIONS: LINC01287 drives proliferative and migratory capacities in HCC via targeting the miR-559/TCF12 axis. +genetics_overexpression_promote 32572913 hsa-mir-22 Wilms Tumor Functionally, overexpression of miR +genetics_overexpression_promote 32572912 hsa-mir-133a Carcinoma, Renal Cell Finally, in vitro cell reverse experiments suggested that overexpression of MON2 counteracted the inhibitory effects of overexpression of microRNA-133a-5p on the proliferation and metastatic capacity of ccRCC. +transcription factor target 32572911 hsa-mir-1246 Carcinoma, Renal Cell MiRNA-1246/CXCR4 axis could be potential therapeutic target for RCC. +other 32572906 hsa-mir-217 Osteosarcoma RESULTS: The expression of LINC00467 and HMGA1 was increased in OS tissues and cells, while miR-217 expression was reduced. +circulation_biomarker_diagnosis_ns 32572900 hsa-mir-21 Spinal Cord Injuries 5p and its target gene PLAG1 in the serum of patients with spinal cord injury (SCI), as well as the role and mechanism of microRNA +transcription factor target 32572899 hsa-mir-128 Diabetic Retinopathy In addition, it suppresses the proliferation and migration of HRECs by targeting miRNA3p/SIRT1 axis, thus influencing the progression of diabetic retinopathy. +other 32572898 hsa-mir-205 Cataract CONCLUSIONS: The low expression of YY1 induces NEAT1 downregulation, which regulates microRNA3p/MMP16 axis and thus participates in the development of DC. +other 32572897 hsa-mir-507 Pre-Eclampsia OBJECTIVE To elucidate the potential influences of miR-507 and CAMK4 on the progression of preeclampsia (PE). +lncRNA target 32572897 hsa-mir-507 Pneumonia, Mycoplasma CONCLUSIONS Highly expressed miR-507 in PE pregnancies inhibits proliferative and migratory potentials, and induces apoptosis in trophoblasts by targeting CAMK4. +genetics_overexpression_suppress 32572895 hsa-mir-147 Myocardial Infarction CONCLUSIONS: In MI, miR-147 expression is decreased in the myocardium and overexpression of miR-147 can inhibit myocardial inflammation and apoptosis and improve cardiac function in rats via targeting HIPK2. +genetics_GWAS 32572893 hsa-mir-146a ankylosing spondylitis 1 OBJECTIVE: The aim of this study was to explore the correlations of micro ribonucleic acid (miR)-146a and interleukin 1 receptor associated kinase 1 (IRAK1) gene polymorphisms with ankylosing spondylitis. CONCLUSIONS: MiR-146a and IRAK1 gene polymorphisms are prominently associated with ankylosing spondylitis. +other 32572892 hsa-mir-340 Pulmonary Fibrosis However, it is elusive whether miR5p exert a pulmonary anti-fibrotic effect on IPF by moderating fibroblast bioactivity. +circulation_biomarker_diagnosis_ns 32572891 hsa-mir-17 Hepatitis B CONCLUSIONS: Serum miR-17 level is highly expressed in HBV patients, and negatively correlated with liver fibrosis severity, which could be utilized as a non-invasive hallmark assessing liver fibrosis severity in HBV patients. +circulation_biomarker_diagnosis_ns 32572891 hsa-mir-17 Liver Cirrhosis CONCLUSIONS: Serum miR-17 level is highly expressed in HBV patients, and negatively correlated with liver fibrosis severity, which could be utilized as a non-invasive hallmark assessing liver fibrosis severity in HBV patients. +other 32572890 hsa-mir-942 Acute Kidney Injury This article aimed to study the role of miR5p in inflammation and apoptosis of septic AKI and its potential mechanism. +lncRNA target 32572888 hsa-mir-448 Hodgkin Disease OBJECTIVE: To explore whether long non-coding RNA nuclear enriched abundant transcript 1 (lncRNA NEAT1) could regulate Hodgkin's lymphoma (HL) cell proliferation and invasion through miR-448, which could target doublecortin like kinase 1 (DCLK1) and mediate DCLK1 expression. CONCLUSIONS: NEAT1 might be contributed to HL progression by promoting cell proliferation and invasion capability via miR-448 mediated DCLK1 expression. +genetics_knock down_suppress 32572887 hsa-mir-186 Glioma Knockdown of miR +other 32572886 hsa-mir-146b Glioma CONCLUSIONS: Circ-RPL15 triggers proliferative and migratory potentials in glioma by competitively binding miR-146b-3p and thus upregulates VEGFA. +genetics_knock down_suppress 32572884 hsa-mir-566 Breast Neoplasms According to the differential expressions of miR-566 in the tested BC cell lines, MDA-MB-231 and MCF-7 cells were selected for generating miR-566 knockdown and overexpression models, respectively. +other 32572881 hsa-mir-217 Lung Neoplasms Finally, cell functional experiments showed that microRNA-217 is a key downstream gene that mediates the regulation of circABCB10 on LCa cell function. +lncRNA target 32572880 hsa-mir-645 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: MiR-645 expression is upregulated in NSCLC tissues and cells, and the proliferation and migration of NSCLC cells are promoted by targeted regulation on the TP53I11 expression. +genetics_overexpression_promote 32572879 hsa-mir-448 Carcinoma, Non-Small-Cell Lung Moreover, functional assays demonstrated that miR-448 overexpression suppressed NSCLC cell proliferation, invasion and migration. +lncRNA target 32572801 hsa-mir-122 Fluorosis, Dental 5p may be involved in the cause and development of skeletal fluorosis by targeting CDK4. +lncRNA target 32572699 hsa-mir-134 Carcinoma, Squamous Cell, Skin MicroRNAs (miRNAs) are involved in the pathogenesis of several cancers including skin squamous cell carcinoma (sSCC), and miR-134 is reported to possess tumor inhibition properties. +circulation_biomarker_diagnosis_ns 32572127 hsa-mir-204 Vascular Diseases This study establishes that miR-204 impairs endothelial function, promotes impairment in blood pressure decline during rest, and opens avenues for miR-204 inhibition strategies against vascular dysfunction. +other 32571650 hsa-mir-139 Wounds and Injuries 5p in wounds. +other 32571650 hsa-mir-124 Wounds and Injuries 3p.1/139-5p in wounds and up-regulation of JAG1/Notch1 in ESCs, thus enhancing cutaneous wound healing. +circulation_biomarker_diagnosis_up 32571464 hsa-mir-183 Lupus Nephritis CONCLUSIONS: There are significant reductions in the expression levels of miR-145 and miR-183 in plasma in children with LN, which are correlated with the activity level and pathological typing of LN. +circulation_biomarker_diagnosis_up 32571464 hsa-mir-145 Lupus Nephritis CONCLUSIONS: There are significant reductions in the expression levels of miR-145 and miR-183 in plasma in children with LN, which are correlated with the activity level and pathological typing of LN. +lncRNA target 32571448 hsa-mir-511 Breast Neoplasms LINC02163 exerts cancer-promoting effects during the initiation and progression of breast cancer via regulation of the miR +other 32571344 hsa-mir-181a Precursor Cell Lymphoblastic Leukemia-Lymphoma CONCLUSIONS: After validating in extensive cohorts, quantification of miR-181a or a specific EV subtype might provide novel tools to monitor CNS disease course and further adjust CNS-directed therapy in pediatric ALL. +genetics_overexpression_promote 32571328 hsa-mir-130a Carcinoma, Non-Small-Cell Lung Following the validation of the supporting role of STK32A in NSCLC cells and NF-kappaB p65 phosphorylation, RUNX2 overexpression was monitored to reverse miR-130a-5p-inhibited NSCLC tumor volume and weight through enhancing STK32A expression in vivo. +other 32571262 hsa-mir-106a Colonic Neoplasms The chr22-38_28785274-29,006,793.1-miR-106a-5p-DDHD1 and chr22-38_28785274-29,006,793.1-miRGRHL1 axes may be related to CD4(+) and CD8(+) T cell infiltration in colon cancer. +other 32571262 hsa-mir-4319 Colonic Neoplasms The chr22-38_28785274-29,006,793.1-miR-106a-5p-DDHD1 and chr22-38_28785274-29,006,793.1-miRGRHL1 axes may be related to CD4(+) and CD8(+) T cell infiltration in colon cancer. +other 32571260 hsa-mir-424 Leukemia, Myeloid, Acute The LASSO-Cox model fitted OS to AML-survival risk scores, which included age, race, molecular risk, expression of IKZF2/LINC00649/LINC00839/FENDRR and has-miR5p. +other 32570259 hsa-mir-497 Urinary Bladder Neoplasms CONCLUSIONS: Our study manifests the first evidence that CASC9 serves as an oncogene in BC and accelerates cell proliferation by modulating miR5p/CBX2 axis. +other 32569788 hsa-mir-146 Hepatitis B, Chronic The expression level of miR-146 in HIV/HCV co-infected patients was the highest in all groups. +other 32569788 hsa-mir-146 Hepatitis C The expression level of miR-146 in HIV/HCV co-infected patients was the highest in all groups. +other 32569788 hsa-mir-146 Acquired Immunodeficiency Syndrome The expression level of miR-146 in HIV/HCV co-infected patients was the highest in all groups. +other 32569592 hsa-mir-34a Testicular Diseases The present study aimed to characterize the role of mir-34a/sirt-1 in CsA induced testicular injury alone or in combination with curcumin. +other 32569501 hsa-mir-146a Behcet Syndrome CONCLUSION: The miR-146a (rs57095329) is associated with Behcet's disease and certain genotypes and alleles with oral ulcers, and with ocular and neurological manifestations. +circulation_biomarker_prognosis_ns 32569211 hsa-mir-103 Sepsis Plasma MIR103 and MIR107 were detected by reverse transcription-quantitative polymerase chain reaction.MIR103 and MIR107 were both decreased in ARDS sepsis patients and non-ARDS sepsis patients compared to HCs, and were reduced in ARDS sepsis patients than non-ARDS sepsis patients. +circulation_biomarker_prognosis_ns 32569211 hsa-mir-107 Respiratory Distress Syndrome Plasma MIR103 and MIR107 were detected by reverse transcription-quantitative polymerase chain reaction.MIR103 and MIR107 were both decreased in ARDS sepsis patients and non-ARDS sepsis patients compared to HCs, and were reduced in ARDS sepsis patients than non-ARDS sepsis patients. +circulation_biomarker_prognosis_ns 32569211 hsa-mir-107 Sepsis Plasma MIR103 and MIR107 were detected by reverse transcription-quantitative polymerase chain reaction.MIR103 and MIR107 were both decreased in ARDS sepsis patients and non-ARDS sepsis patients compared to HCs, and were reduced in ARDS sepsis patients than non-ARDS sepsis patients. +circulation_biomarker_prognosis_ns 32569211 hsa-mir-103 Respiratory Distress Syndrome Plasma MIR103 and MIR107 were detected by reverse transcription-quantitative polymerase chain reaction.MIR103 and MIR107 were both decreased in ARDS sepsis patients and non-ARDS sepsis patients compared to HCs, and were reduced in ARDS sepsis patients than non-ARDS sepsis patients. +other 32568775 hsa-mir-187 Anxiety Disorders Our data provides a basis for the potential therapeutic benefits of miR3p/SATB2 in the treatment of anxiety disorders induced from fear memory. +lncRNA target 32568328 hsa-mir-29a Necrosis Moreover, the in vitro experiments showed that the expression of mir-29a-3p decreased as the Se content in the medium decreased and the application of an mir-29a-3p inhibitor increased the number of necrotic cells and the accumulation of ROS, and these effects were inhibited by necrostatin-1 (Nec-1) and N-acetyl-cysteine (NAC), respectively. +transcription factor target 32568181 hsa-mir-186 Nasopharyngeal Carcinoma FOXD1 mRNA and miR-186 expression in NPC tissues and cells was detected using quantitative polymerase chain reaction (qPCR). CONCLUSION: FOXD1, which is negatively regulated by miR-186, acts as a novel oncogene in NPC and serves as potential biomarker and therapeutic target for NPC. +genetics_knock down_promote 32568179 hsa-mir-143 Prostatic Neoplasms, Castration-Resistant The overexpression of miR +circulation_biomarker_diagnosis_up 32568176 hsa-mir-638 Leukemia, Promyelocytic, Acute We investigated whether miR-638 in circulating leukaemia cells is a non-invasive biomarker in diagnosis, assessment of the treatment response and minimal residual disease (MRD) surveillance of APL. +lncRNA target 32568175 hsa-mir-411 Carcinoma, Non-Small-Cell Lung 5p and suppress its expression. +lncRNA target 32568133 hsa-mir-487b Osteosarcoma Five of the 75 overlapping target genes of miR3p and miR-487b-5p were downregulated in osteosarcoma, including ZBTB20, ADAMTS4, GLIPR2, CLIC5 and CBX7. +lncRNA target 32568133 hsa-mir-411 Osteosarcoma Five of the 75 overlapping target genes of miR3p and miR-487b-5p were downregulated in osteosarcoma, including ZBTB20, ADAMTS4, GLIPR2, CLIC5 and CBX7. +genetics_overexpression_promote 32567955 hsa-mir-27b Glioma Furthermore, in our study, overexpression of miR-27b-3p also inhibited the growth of xenografted glioma tumors in-vivo. +other 32567937 hsa-mir-96 Carcinoma, Pancreatic Ductal On the other hand, miR-96 and miR-217 were significantly downregulated in PDACs (up to one hundred times). +other 32567937 hsa-mir-217 Carcinoma, Pancreatic Ductal On the other hand, miR-96 and miR-217 were significantly downregulated in PDACs (up to one hundred times). +circRNA target 32567935 hsa-mir-326 Rectal Neoplasms CircABCB10 silence promoted rectal cancer cell ferroptosis and apoptosis by regulating the miR-326/CCL5 axis, suggesting a potential therapeutic target for rectal cancer therapy. +genetics_overexpression_suppress 32567934 hsa-mir-15a Stomach Neoplasms Our results indicated that miR-15a-5p overexpression increased cisplatin resistance of gastric cancer cells, whereas miR-15a-5p downregulation decreased the resistance. +other 32567701 hsa-mir-26a Non-alcoholic Fatty Liver Disease CONCLUSIONS: Our findings suggest ER stress-induced miR-26a up-regulation as a regulator for hepatic ER stress resolution, and highlight the ER stress/miR-26a/eukaryotic initiation factor 2alpha cascade as a promising therapeutic strategy for NAFLD. +genetics_overexpression_promote 32567032 hsa-mir-550a Esophageal Squamous Cell Carcinoma Moreover, rescue assays revealed that overexpression of NFIC attenuated the promoting effects of miR-550a-3 on ESCC cells malignant behaviors. +circRNA target 32566582 hsa-mir-1257 Tuberculosis CONCLUSIONS: In active tuberculosis, circAGFG1 enhances autophagy and reduces apoptosis via the miRNA-1257/Notch axis; this provides new therapeutic targets for tuberculosis patients. +other 32566292 hsa-mir-137 Schizophrenia We found gene expression differences related to miRNA-137 and other SZ-associated microRNAs, ELAVL1, BDNF, DISC-1, MECP2 and YWHAG associated findings, synapses, and receptors. +lncRNA target 32566081 hsa-mir-134 Hypoxia-Ischemia, Brain In this study, we investigated the putative involvement of lncRNA AK046177 and microRNA-134 (miR-134) regulation in SYB against ischemia/reperfusion- (I/R-) induced neuronal injury. We suggested that the antioxidant effects of SYB were driven by an AK046177/miR-134/CREB-dependent mechanism that inhibited this pathway, and that SYB has potential use in reducing or possibly preventing I/R-induced neuronal injury. +other 32566038 hsa-mir-28 Colonic Neoplasms 5p was increased in colon cancer and can be an independent indicator for the overall survival in patients with colon cancer. +lncRNA target 32566037 hsa-mir-7 Pancreatic Carcinoma Our recent study has indicated that microRNA-7 (miR-7) impairs autophagy-derived pools of glucose to suppress the glycolysis in pancreatic cancer progression. +transcription factor target 32566020 hsa-mir-141 Colorectal Neoplasms In conclusion, low expression levels of miR-135a-5p and miR-141 in colorectal adenomas suggested that miR-135a-5p and miR-141 could act as tumor suppressors in the development of colorectal adenomas; miR-135a-5p and miR-141 inhibited the proliferation and invasion of colon cancer SW620 cells and promoted apoptosis of colon cancer cells. +transcription factor target 32566020 hsa-mir-135a Colorectal Neoplasms In conclusion, low expression levels of miR-135a-5p and miR-141 in colorectal adenomas suggested that miR-135a-5p and miR-141 could act as tumor suppressors in the development of colorectal adenomas; miR-135a-5p and miR-141 inhibited the proliferation and invasion of colon cancer SW620 cells and promoted apoptosis of colon cancer cells. +target gene 32566017 hsa-mir-34a Carcinoma, Hepatocellular Long non-coding RNA SNHG7 inhibits NLRP3-dependent pyroptosis by targeting the miR-34a/SIRT1 axis in liver cancer. +other 32566002 hsa-mir-181a Multiple Myeloma MiR-181a functions as an oncogene by regulating CCND1 in multiple myeloma. +target gene 32566001 hsa-mir-203 Esophageal Neoplasms miR-203 affects esophageal cancer cell proliferation, apoptosis and invasion by targeting MAP3K1. +target gene 32565999 hsa-mir-32 Ovarian Neoplasms MicroRNA-32 promotes ovarian cancer cell proliferation and motility by targeting SMG1. +genetics_overexpression_promote 32565974 hsa-mir-25 Stomach Neoplasms miR-25 overexpression partially rescued the decreased migration and invasion of GA cells caused by PMS2L2 overexpression. +lncRNA target 32565956 hsa-mir-208b Carcinoma, Non-Small-Cell Lung Furthermore, enhanced IL-9 level decreased the miR-208b-5p-mediated suppression of epithelial-mesenchymal transition in NSCLC cells by inactivating the STAT3 signaling pathway. +target gene 32565955 hsa-mir-15a Liver Neoplasms Vitamin D3 mediates miR-15a-5p inhibition of liver cancer cell proliferation via targeting E2F3. +circRNA target 32565953 hsa-mir-554a Colorectal Neoplasms Furthermore, hsa_circ_RNA_0011780 downregulates FBXW7 by targeting miR-554a and suppressing the progression of non-small cell lung cancer. +circRNA target 32565953 hsa-mir-31 Colorectal Neoplasms 3p, and that hsa_circ_0038646 could increase the levels of GRIK3 by suppressing miR +genetics_knock down_promote 32565945 hsa-mir-194 Squamous Cell Carcinoma of Head and Neck In conclusion, the results of the present study suggested that MALAT1 knockdown suppressed the malignant behavior of HSCC by targeting miR-194; therefore, MALAT1 may serve as a novel therapeutic target for HSCC. +other 32565910 hsa-mir-141 Angelman Syndrome 3p/ROR2 axis. +other 32565880 hsa-mir-495 Pulmonary Disease, Chronic Obstructive 5p, and transcription factors such as MYC, BRCA1, and CDX2, significantly regulate COPD dysfunction blocks. +other 32565880 hsa-mir-186 Pulmonary Disease, Chronic Obstructive 5p, and transcription factors such as MYC, BRCA1, and CDX2, significantly regulate COPD dysfunction blocks. +other 32565880 hsa-mir-590 Pulmonary Disease, Chronic Obstructive 5p, and transcription factors such as MYC, BRCA1, and CDX2, significantly regulate COPD dysfunction blocks. +genetics_overexpression_promote 32565736 hsa-mir-24 Triple Negative Breast Neoplasms 3p repression or SUDS3 overexpression could rescue the anti-tumor effect of SNHG22 silencing on the malignant phenotypes of TNBC cells. +lncRNA target 32565733 hsa-mir-6869 Glioma 5p regulated glioma cell proliferation and invasion via targeting PGK1. +transcription factor target 32564679 hsa-mir-375 Inflammation This study aimed to investigate whether miR3p could regulate AD through the Yes-associated protein 1 (YAP1) pathway. +other 32564659 hsa-mir-516b Colorectal Neoplasms The expression of circRNA_100876 and microRNA-516b (miR-516b) was compared in normal and CRC tissues using quantitative real-time polymerase chain reaction (RT-qPCR). +other 32563982 hsa-mir-424 Osteosarcoma Collectively, these findings uncovered the function of TFAP2C/LINC00922/miR5p feedback loop in DXR resistance, suggesting new therapeutic direction for OS. +epigenetics 32563914 hsa-mir-663 Skin Diseases Promoter hypermethylation with significantly decreased expression of miR663 was found in skin cancer tissues compared to non-cancerous control tissue. +epigenetics 32563914 hsa-mir-663 Skin Neoplasms Promoter hypermethylation with significantly decreased expression of miR663 was found in skin cancer tissues compared to non-cancerous control tissue. +circulation_biomarker_diagnosis_ns 32563236 hsa-mir-21 Atrophy CONCLUSIONS High miR-21 in plasma exosome, but not in whole plasma, indicated high grade IF/TA in post-KT patients. +circulation_biomarker_diagnosis_ns 32563236 hsa-mir-21 Renal Allograft Dysfunction CONCLUSIONS High miR-21 in plasma exosome, but not in whole plasma, indicated high grade IF/TA in post-KT patients. +lncRNA target 32563177 hsa-mir-200a Carcinoma, Hepatocellular Increasing miR-200a expression inhibited HCC growth and synergized with the antitumor effects of doxorubicin. +other 32563176 hsa-mir-224 Carcinoma, Hepatocellular Previous studies have been reported that miR-224 is upregulated in hepatocellular carcinoma (HCC) tissues and sera samples. +lncRNA target 32563146 hsa-mir-144 Neuroblastoma In conclusion, NORAD promoted the progression and DOX resistance of NB through miR +genetics_GWAS 32562900 hsa-mir-146a Tooth, Supernumerary CONCLUSION: Genetic variants of miR-146a/rs2910164 and miR-618/rs2682818 were likely associated with the risk of NSST in the Chinese population. +genetics_GWAS 32562900 hsa-mir-618 Tooth, Supernumerary CONCLUSION: Genetic variants of miR-146a/rs2910164 and miR-618/rs2682818 were likely associated with the risk of NSST in the Chinese population. +circulation_biomarker_diagnosis_up 32562719 hsa-mir-128-1 Glioma Therein, the aim of this study is to discuss the impacts of lncRNA plasmacytoma variant translocation 1 (PVT1)/microRNA +circulation_biomarker_diagnosis_up 32562465 hsa-mir-92a-1 Colorectal Neoplasms Serum miR-92a-1 may be a potential diagnostic biomarker for CRC. +other 32562373 hsa-mir-155 Cartilage Diseases We report here that miR-155 level is significantly up-regulated in human OA cartilage biopsies and also in primary chondrocytes stimulated by interleukin-1beta (IL-1beta), a pivotal pro-catabolic factor promoting cartilage degradation. Altogether, our study discovers novel roles and mechanisms of miR-155 in regulating chondrocyte apoptosis and catabolic activity, providing an implication for therapeutically intervening cartilage degradation and OA progression. +other 32562373 hsa-mir-155 Osteoarthritis Altogether, our study discovers novel roles and mechanisms of miR-155 in regulating chondrocyte apoptosis and catabolic activity, providing an implication for therapeutically intervening cartilage degradation and OA progression. +other 32562304 hsa-mir-223 Stomach Neoplasms The role of hsa_circ_0023642 in GC was assessed in vitro, and biotin-coupled RNA pull-down was conducted to evaluate the interaction in between hsa_circ_0023642 and miR-223. We confirmed that hsa_circ_0023642 could serve as a sponge of miR-223, subsequently promoting GC progression. +lncRNA target 32562135 hsa-mir-140 Osteosarcoma 3p mimic dramatically inhibited while a miR +lncRNA target 32561925 hsa-mir-515 Retinoblastoma CONCLUSION: Altogether, these data demonstrated that ZFPM2-AS1 interacted with HOXA1 to promote RB development via mediating miR-515, establishing a promising therapeutic biomarker for RB and prognosis. +lncRNA target 32561739 hsa-mir-587 Obesity Our results suggest that RP11-142A22.4 can control adipocyte differentiation via the miR-587/Wnt5beta signaling pathway and serve as a potential target for obesity treatments. +lncRNA target 32561494 hsa-mir-1 Crohn Disease RESULTS: ALK1 was identified as a target of miR +circulation_biomarker_diagnosis_up 32561396 hsa-mir-223 Diabetic Cardiomyopathies Additionally, we found that inhibition of miR-223 had obvious positive effects on the cardiac dysfunction and reduced the elevation of blood sugar in the DCM model rats. +circulation_biomarker_diagnosis_up 32561396 hsa-mir-223 Diabetic Nephropathies Additionally, we found that inhibition of miR-223 had obvious positive effects on the cardiac dysfunction and reduced the elevation of blood sugar in the DCM model rats. +lncRNA target 32561161 hsa-mir-214 Osteoporosis Therefore, pseudogene PTENP1 sponged miR-214 to regulate the expression of PTEN to inhibit osteoclast differentiation and attenuate osteoporosis by suppressing the PI3K/AKT/NF-kappaB signaling pathway. +lncRNA target 32560824 hsa-mir-135a Stomach Neoplasms For the mechanism study, we applied luciferase reporter assay, RNA pull-down assay, as well as RIP assay to validate the interation of ciRS-7, miR-135a-5p and TRPC1 in GC cells. This study, we showed that TRPC1 exacerbate EMT in gastric cancer via ciRS-7/miR-135a-5p/TRPC1 axis, and target TRPC1 could be beneficial for end-stage GC patients. +genetics_overexpression_promote 32560730 hsa-mir-669c Ischemic Stroke Intracerebral overexpression of miR-669c significantly decreased the ischemia-induced cell death and ameliorated the stroke-induced neurological deficits both at 1 and 3 days post injury (dpi). +lncRNA target 32560314 hsa-mir-941 Arthritis, Psoriatic The miR-941 could be a potential biomarker and treatment target for PsA. +circulation_biomarker_diagnosis_ns 32560275 hsa-mir-451a Cystic Fibrosis RESULTS: The miRNA profiling showed that four miRNAs (miR-223, miR-451a, miR-27b-3p, miR5p) were significantly altered during pulmonary exacerbation in CF patients in sputum but did not differ significantly in blood. +circulation_biomarker_diagnosis_ns 32560275 hsa-mir-223 Cystic Fibrosis RESULTS: The miRNA profiling showed that four miRNAs (miR-223, miR-451a, miR-27b-3p, miR5p) were significantly altered during pulmonary exacerbation in CF patients in sputum but did not differ significantly in blood. +circulation_biomarker_diagnosis_ns 32560275 hsa-mir-27b Cystic Fibrosis RESULTS: The miRNA profiling showed that four miRNAs (miR-223, miR-451a, miR-27b-3p, miR5p) were significantly altered during pulmonary exacerbation in CF patients in sputum but did not differ significantly in blood. +other 32560271 hsa-let-7 Breast Neoplasms In conclusion, CAIX-driven regulation of the LIN28/let-7 axis augments glycolytic metabolism and enhances stem cell markers expression during CAIX-mediated adaptation to hypoxia and acidosis in carcinogenesis. +other 32559850 hsa-mir-502 Stomach Neoplasms 3p/OLFM4/STAT3 axis. +lncRNA target 32559621 hsa-mir-641 Pancreatic Carcinoma CONCLUSIONS: Long non-coding RNA LINC01963 inhibits progression of pancreatic carcinoma by targeting miR-641/TMEFF2. +lncRNA target 32559619 hsa-mir-34a Adenocarcinoma of Lung Conclusively, HCG18 acted an oncogene in LUAD and enhanced LUAD progression by targeting miR-34a-5p/HMMR axis. +other 32559617 hsa-mir-4685 Aortic Aneurysm, Abdominal 5p/LBX2 axis in AAA management. +other 32559610 hsa-mir-195 Schizophrenia CONCLUSION: Our data indicate that miR-195 is associated with cognitive impairment in female SZ patients, and it may be involved in the underlying mechanism of sex differences in cognitive impairment in SZ. +other 32559610 hsa-mir-195 Alzheimer Disease CONCLUSION: Our data indicate that miR-195 is associated with cognitive impairment in female SZ patients, and it may be involved in the underlying mechanism of sex differences in cognitive impairment in SZ. +lncRNA target 32559300 hsa-mir-130b Polycystic Ovary Syndrome In conclusion, miR-130b was increased in PCOS granulosa cells, where it targets Cx43 to affect GJIC. +genetics_knock down_promote 32559140 hsa-mir-141 Pulmonary Arterial Hypertension SMILR knockdown or miR-141 overexpression inhibited hypoxia-induced cell proliferation and migration via repressing RhoA/ROCK signaling in pulmonary arterial smooth muscle cells (PASMCs), which was confirmed in vivo experiments that knockdown of SMILR inhibited vascular remodeling and alleviated PAH in rats. +other 32559121 hsa-mir-155 Breast Neoplasms In this study, a PNA sequence that undergoes complementary binding to miR-155 was labeled with (99m)Tc to evaluate whether the tracer could visualize the expression of miR-155 in breast cancer. We successfully demonstrated that [(99m)Tc]anti-PNA-155 could visualize miR-155 expression in vivo, suggesting it may be a promising probe applied in breast cancer. +other 32558970 hsa-mir-342 Carcinoma, Squamous Cell, Cutaneous 3p expression in cSCC cells. +genetics_GWAS 32558936 hsa-mir-17 Teratoid Rhabdoid Tumor, Atypical Here, we show that SMARCB1 loss in ATRT leads to the reduction of cyclin D1 expression by upregulating MIR17HG, a microRNA (miRNA) cluster known to generate multiple miRNAs targeting CCND1. Our study identifies a novel genetic interaction between SMARCB1 and MIR17HG in regulating cyclin D1 in ATRT and suggests a rationale to treat ATRT patients with FDA-approved CDK4/6 inhibitors. +other 32558619 hsa-mir-106b Carotid Stenosis Our present results provide evidence for miR-106b-5p as a promising biomarker for CAS diagnosis, and for predicting the risk of future CIE in patients with asymptomatic CAS. +other 32558619 hsa-mir-106b Brain Ischemia Our present results provide evidence for miR-106b-5p as a promising biomarker for CAS diagnosis, and for predicting the risk of future CIE in patients with asymptomatic CAS. +genetics_overexpression_promote 32558530 hsa-mir-497 Breast Neoplasms Overall, our results demonstrated that overexpression of LINC00662 accelerated the malignant growth of breast cancer cells via sponging miR5p and upregulating EglN2 expression, and indicate that targeting LINC00662 may represent a novel strategy for breast cancer therapy. +other 32558399 hsa-mir-22 Reperfusion Injury, Cerebral Ischemia Additionally, HSP90AA1, HSPA5, MYC, HSF1, and miR-22 might be related to the pathogenesis of I/R injury. +genetics_knock down_suppress 32558350 hsa-mir-206 Carcinoma, Hepatocellular Finally, our in vivo experiments validated that the knockdown of FOXD2-AS1 inhibited HCC progression by modulating the miR-206/MAP3K1 axis. +lncRNA target 32558345 hsa-mir-744 Carcinoma, Ovarian Epithelial 5p attenuated EOC progression via targeting IRF1, providing potential guidance for the clinical treatment of ovarian cancer. +lncRNA target 32558224 hsa-mir-128 Breast Neoplasms 3p inhibits the stem-like cell features of BCSCs via inhibition of the Wnt signalling pathway by down-regulating NEK2, which provides a new target for breast cancer treatment. +lncRNA target 32558131 hsa-mir-23b Ataxia Neuropathy Spectrum Our findings reveal a novel role for LINC00261 in regulating H/R cardiomyocyte apoptosis and the potency of the LINC00261/miR-23b-3p/NRF2 axis as a therapeutic target for the treatment of MIRI. +other 32558113 hsa-mir-183 Amyotrophic Lateral Sclerosis MicroRNA-183-5p is stress-inducible and protects neurons against cell death in amyotrophic lateral sclerosis. +other 32558033 hsa-mir-1908 Prostatic Neoplasms In conclusion, our results showed that miRmediated regulation of SRM can control secretion of EVs in PCa. +genetics_GWAS 32557866 hsa-mir-21 Coronary Artery Disease CONCLUSION: Single nucleotide polymorphisms of lncRNA GAS5/miR-21/mTOR axis might interact with smoking to regulate CHD risk, which was conducive to diagnosis and prognostic anticipation of CHD. +other 32557804 hsa-let-7a Obesity In obese animals or nonalcoholic fatty liver disease (NAFLD) patients, let-7a and miR-34a levels were elevated with simultaneous decreases in ATG4B and Rab-8B levels. +other 32557804 hsa-mir-34a Obesity In obese animals or nonalcoholic fatty liver disease (NAFLD) patients, let-7a and miR-34a levels were elevated with simultaneous decreases in ATG4B and Rab-8B levels. +lncRNA target 32557658 hsa-mir-144 Diabetes Mellitus, Type 2 Eventually, NR3C1 was proved to be a stress-related target gene of miR-144, indicating that pri-miR-144 rs9279 may contribute to the development of T2D by altering regulation of stress response. +genetics_overexpression_suppress 32557241 hsa-mir-338 Neuralgia TRPV1 overexpression abolished the inhibitory effect by miR +transcription factor target 32556943 hsa-mir-137 Metabolic Diseases Contrarily, expression of the mitomiRs miR15a, miR-137, and miR-181c, which target mitochondrial genes that support mitochondrial structure, energy pathways, and dynamics, was higher in MetS-MSCs compared to Lean-MSCs, suggesting a potential to modulate their expression. +transcription factor target 32556943 hsa-mir-181c Metabolic Diseases Contrarily, expression of the mitomiRs miR15a, miR-137, and miR-181c, which target mitochondrial genes that support mitochondrial structure, energy pathways, and dynamics, was higher in MetS-MSCs compared to Lean-MSCs, suggesting a potential to modulate their expression. +lncRNA target 32556917 hsa-mir-30 Uterine Cervical Neoplasms Our study revealed that EWSAT1 enhances CPEB4 expression through sponging miR5p, thereby promoting cervical cancer development, which might provide potential therapeutic targets for clinically cervical cancer patients. +transcription factor target 32556802 hsa-mir-103a Sepsis miR-103a-3p agomir could alleviate liver injury including the tissue injury and mitochondrial damage, inhibit the secretion of inflammatory factors, and decrease the apoptosis of liver cells. +transcription factor target 32556802 hsa-mir-103 Sepsis miR-103a-3p agomir could alleviate liver injury including the tissue injury and mitochondrial damage, inhibit the secretion of inflammatory factors, and decrease the apoptosis of liver cells. +other 32556678 hsa-mir-30 Sepsis 5p in LPS-induced myocardial injury. +other 32556677 hsa-mir-128 Carcinoma, Non-Small-Cell Lung Our study highlighted the mechanistic contribution of the MIAT/miR3p/PELI3 signaling cascade in NSCLC. +other 32556361 hsa-mir-155 Folliculotropic Mycosis Fungoides Thus, similar to classic MF, miR-155, Ki-67 tumour cell immunoreactivity, and certain tumour-infiltrating inflammatory cells are differentially expressed in early- vs tumour-stage FMF. +lncRNA target 32556351 hsa-mir-106b Mycosis Fungoides Transfection of miR-106b in 2 mycosis fungoides derived cell lines showed that miR-106b represses the tumour suppressors cyclin-dependent kinase inhibitor 1 (p21) and thioredoxin-interacting protein (TXNIP) and promotes mycosis fungoides tumour cell proliferation. +genetics_knock down_promote 32555725 hsa-mir-18a Uterine Cervical Neoplasms Interestingly, miR-18a knockdown increased STK4 expression and activated the Hippo pathway, significantly reducing cervical cancer cell proliferation. +genetics_knock down_promote 32555725 hsa-mir-18a Papillomavirus Infections Interestingly, miR-18a knockdown increased STK4 expression and activated the Hippo pathway, significantly reducing cervical cancer cell proliferation. +transcription factor target 32555626 hsa-mir-410 Melanoma 3p is induced by vemurafenib in melanoma cells via ER stress. +exosome 32555395 hsa-mir-133a Endometrial Neoplasms Furthermore, we isolated exosomes from the culturing supernatants of endometrial cancer cells (Ishikawa and HECA) and found that miR-133a, which regulates expression of FOXL2, were present in exosomes and that they could be delivered to normal endometrial cells. +genetics_overexpression_promote 32555352 hsa-mir-873 Nasopharyngeal Carcinoma Collectively, the results obtained suggest that overexpression of miR-873 could aid NPC tumor suppression through reduction of the malignant potential of CSCs. +lncRNA target 32555332 hsa-mir-1300 Glioblastoma In GBM cells, where miR-1300 is normally not expressed, the oncogene Epithelial Cell Transforming 2 (ECT2) was validated as a direct key target. We showed that ectopic expression of miR-1300 led to decreased tumor growth in an orthotopic GBM model. +genetics_overexpression_promote 32554962 hsa-mir-146a Urinary Bladder Neoplasms Overexpression of miR-146a-5p promoted, while overexpression of lncRNA MORT inhibited the invasion, migration, and proliferation of cells of bladder cancer cell lines. +genetics_knock down_suppress 32554905 hsa-mir-214 Uterine Cervical Neoplasms CRISPR-facilitated knockdown and plasmid-based overexpression of miR-214 was performed in cervical cancer cell lines HeLa, C33A and CaSki. A combination of miR-214 overexpression and Paclitaxel treatment was found to be most effective in inducing cell death in cervical cancer cells. +genetics_overexpression_promote 32554866 hsa-mir-548c Carcinoma, Hepatocellular Downregulation of miR-548c-3p or overexpression of LAMC2 restored migration and proliferation abilities of HCC cells following hsa_circ_0101145 silencing. +other 32554858 hsa-mir-542 Prostatic Neoplasms Taken together, our results show that LINC00963 acts as an inducer of PCa metastasis by binding miR3p, thereby promoting NOP2. +transcription factor target 32554856 hsa-mir-145 Heart Failure CONCLUSION: miR-145 effectively alleviates HF-related cardiac remodeling by improving cardiac dilation, fibrosis, intracellular Ca(2+) mishandling and electrophysiological instability. +lncRNA target 32554852 hsa-mir-126 Esophageal Squamous Cell Carcinoma Furthermore, STAT3 knock-down rescued the effects on autophagy and apoptosis caused by miR-126 inhibition in ESCC cells. +lncRNA target 32554251 hsa-mir-183 COVID-19 The corresponding common targets of the five FUs were all significantly enriched in Go Ontology (oxidoreductase activity, lipid metabolic process, homeostatic process, etc.), KEGG pathways (steroid biosynthesis, PPAR signaling pathway, adipocytokine signaling pathway, etc.), TTD diseases (chronic inflammatory diseases, asthma, chronic obstructive pulmonary Disease, etc.), miRNA (MIR183), kinase (CDK7) and TF (LXR). +lncRNA target 32553931 hsa-mir-410 Osteosarcoma SIGNIFICANCE: Magnoflorine inhibited the malignant phenotypes and increased cisplatin sensitivity of OS cells via modulating miR +transcription factor target 32552957 hsa-mir-335 Anemia, Aplastic 5p in AA-PBMNC could significantly inhibited the activation of CD4(+) and CD8(+) T cells (P0.01 and P0.01, respectively). +genetics_GWAS 32552942 hsa-mir-146a Precursor Cell Lymphoblastic Leukemia-Lymphoma CONCLUSION: The up-regulation of microRNA-146a and STAT1 protein may be involved in occurrence and development of ALL, which closely relates to clinical characteristics in ALL children, such as disease risk, chemotherapy stage and gene mutation. +transcription factor target 32552941 hsa-mir-218 Leukemia, Promyelocytic, Acute OBJECTIVE: To explore the molecular mechanism by which miR-218 targeting Bmi-1 inhibits the proliferation of acute promyelocytic leukemia (APL) cells. +lncRNA target 32552940 hsa-mir-181b Leukemia, Lymphocytic, Chronic, B-Cell Through bioinformatics prediction and combined with literature reports, it is speculated that CARD11 and ZFP36L1 as target genes of miR-181b may be participated in the occurrence and development of CLL. +other 32552939 hsa-mir-425 Leukemia, Myelogenous, Chronic, BCR-ABL Positive OBJECTIVE: To investigate the function and mechanism of transcription factor of MEIS1 and miR-425 to the proliferation of chronic myeloid leukemia cell K562. +genetics_overexpression_promote 32552937 hsa-mir-124 Leukemia, Myelogenous, Chronic, BCR-ABL Positive 3p mimic control, ABCA2-overexpression and mimic+PC ABCA2. +exosome 32552875 hsa-mir-29a Colorectal Neoplasms Sustained reductions in exosomal and cellular levels of miR-29a-3p (a microRNA upregulated in CRC and associated with decreased expression of the tumor suppressor WWOX gene) was documented. +other 32552820 hsa-mir-129 Bone Diseases CONCLUSIONS: LINC00314 confers contributory function in the osteogenic differentiation of ADSCs and thus the LINC00314/miR5p/GRM5 axis may be a novel mechanism for osteogenic-related disease. +other 32552766 hsa-mir-143 Carcinoma, Hepatocellular CONCLUSION: Circ0003998 promotes EMT of HCC by circ0003998/miR3p/FOSL2 axis and circ0003998 /PCBP1/CD44v6 axis. +genetics_knock down_suppress 32552669 hsa-mir-326 Encephalitis, Japanese The knockdown of circ_0000220 or overexpression of miR3p caused a lower production of JEV-induced inflammatory cytokines. +lncRNA target 32552665 hsa-mir-182 Cataract, Age-Related Nuclear 5p inhibited lens epithelial cells apoptosis through regulating NOX4 and p38 MAPK signaling, providing a novel biomarker for treatment of age-related cataract. +other 32552638 hsa-mir-210 Stomach Neoplasms CONCLUSIONS: In conclusion, the present study highlighted that preoperative miR-210 could serve as a potential predictor for POD in elderly GC patients undergoing curative resection. +other 32552146 hsa-mir-586 Uterine Cervical Neoplasms Both hsa-miR-586 and hsa-miR-622 were highly expressed in the cancerous tissues of the cervical cancer patients, whereas PTEN expression was low. +other 32552146 hsa-mir-622 Uterine Cervical Neoplasms Both hsa-miR-586 and hsa-miR-622 were highly expressed in the cancerous tissues of the cervical cancer patients, whereas PTEN expression was low. +epigenetics 32552060 hsa-mir-124 Colorectal Neoplasms The potential role of miR-124 expression in CRC cells was investigated using the demethylation reagent 5-Aza-CdR and transfection of miR-124 mimic/antimir. +genetics_overexpression_promote 32552050 hsa-mir-6089 Arthritis, Rheumatoid The overexpression of CCR4 reversed the effect of miR-6089 on proliferation and apoptosis in RA-FLSs effectively. +genetics_knock down_promote 32552008 hsa-mir-129 Stomach Neoplasms 5p and knockdown of HOXC10 could enhance the chemosensitivity of MGC-803/AP and AGS/AP cells. +epigenetics 32551941 hsa-mir-214 Sepsis Therefore, GAS5 may upregulate miR-214 through methylation pathway to inhibit the apoptosis of cardiomyocytes in sepsis. +other 32551441 hsa-mir-15a Crohn Disease 3p correlated (P < 0.05) with both CDAI and CDEIS whereas miR-15a-5p correlated only with CDEIS. +other 32551441 hsa-mir-192 Crohn Disease 3p correlated (P < 0.05) with both CDAI and CDEIS whereas miR-15a-5p correlated only with CDEIS. +other 32551232 hsa-mir-1 Lung Neoplasms A pathway analysis in the Kyoto Encyclopedia of Genes and Genomes (KEGG) showed that miRNA-1, which was found downregulated in exposed workers, is involved in the lung cancer oncogenesis. +lncRNA target 32551039 hsa-mir-320d Heart Neoplasms Taken together, our data suggested that miR-320d acts as a tumor suppressor in GCA by directly targeting FoxM1 and thus potentially serves as a biomarker for anti-GCA therapy in GCA patients. +genetics_knock down_suppress 32550900 hsa-mir-421 Myocardial Ischemia Conclusions: Using loss/gain-of function method, we demonstrated that miR-421/FOXO3a is the direct target of circHIPK3, and UMSC-Exo prevent ischemic injury by releasing circHIPK3, which in turn down regulate miR-421, resulting in increased expression of FOXO3a, leading to inhibition of pyroptosis and release of IL-1beta and IL-18. +genetics_knock down_suppress 32550900 hsa-mir-421 Syphilis Conclusions: Using loss/gain-of function method, we demonstrated that miR-421/FOXO3a is the direct target of circHIPK3, and UMSC-Exo prevent ischemic injury by releasing circHIPK3, which in turn down regulate miR-421, resulting in increased expression of FOXO3a, leading to inhibition of pyroptosis and release of IL-1beta and IL-18. +lncRNA target 32550898 hsa-mir-200 Head and Neck Neoplasms Results: We found that the cleavable PEG layer responded to low extracellular pH, and that the CPP and targeting peptides were exposed to improve the uptake and release of miR-200 and irinotecan into HNC human tongue squamous carcinoma (SAS) cells. +other 32550890 hsa-mir-144 Uterine Cervical Neoplasms Moreover, miR3p was significantly downregulated and FABP5 was upregulated in CCa in a hypoxic microenvironment. +lncRNA target 32550826 hsa-mir-485 Carcinoma, Renal Cell CONCLUSION: CircHIPK3 promotes the proliferation and metastasis and inhibits the apoptosis of RC cells through competitively binding to miR3p. +lncRNA target 32550825 hsa-mir-377 Carcinoma, Non-Small-Cell Lung Circ_0000284 was a cancer-promoting circRNA in NSCLC via regulating the miR +other 32550556 hsa-mir-221 Carcinoma, Ductal, Breast Higher expression of miR-221, an oncomiR that facilitates entry into the cell cycle S-phase, is regulated by c-MYC, which is expressed more in breast cancer samples from B/AA patients. +other 32550556 hsa-mir-135b Carcinoma, Ductal, Breast Furthermore, the cell migration- and invasion-promoting miRNA, miR-135b, has increased relative expression in B/AA patients. +transcription factor target 32550164 hsa-mir-1 Diabetic Cardiomyopathies CONCLUSION: We showed that HIIT is more effective than CET for reduction of diabetic cardiomyopathy as a complication of diabetes in animal models through suppressing miR-1 and its downstream apoptosis pathway. +transcription factor target 32550164 hsa-mir-1 Diabetes Mellitus CONCLUSION: We showed that HIIT is more effective than CET for reduction of diabetic cardiomyopathy as a complication of diabetes in animal models through suppressing miR-1 and its downstream apoptosis pathway. +transcription factor target 32550152 hsa-mir-29b Diabetic Nephropathies As miR-29b is downregulated in diabetes and HDAC4, TGF-beta1 and IL-6 could be the possible therapeutic targets in DN, our study was focussed on unveiling the role of miR-29b in modulation of HDAC4 and hence, in podocyte dysfunction and renal fibrosis in DN. +other 32550011 hsa-mir-674 Endotoxemia 5p/XBP-1 signaling axis may mitigate endotoxemia -induced intestinal injury. +genetics_overexpression_suppress 32549793 hsa-mir-345 Carcinoma, Hepatocellular 5p elevation counteracted the promotion effect of circ_0027345 overexpression on development of HCC cells. +target gene 32549789 hsa-mir-150 Uterine Cervical Neoplasms MIAT inhibits proliferation of cervical cancer cells through regulating miR-150-5p. +genetics_knock down_suppress 32549788 hsa-mir-195 Thyroid Cancer, Papillary CONCLUSION: Circ_LDLR knockdown decelerated PTC progression by regulating miR +lncRNA target 32549769 hsa-mir-103 X-linked juvenile retinoschisis 1 miR-103 may be explored as a promising diagnostic marker and therapeutic target for RSA. +genetics_overexpression_promote 32549762 hsa-mir-4516 Pancreatic Carcinoma Further, overexpression of miR-4516 suppressed xenograft pancreatic tumor growth in vivo. +circulation_biomarker_diagnosis_up 32549330 hsa-mir-342 Neurodegenerative Diseases MicroRNAs miR-146a-5p (up in cervical spinal cord) and miR3p (down in cervical spinal cord, cerebellum and plasma), both indicated in neurodegenerative diseases earlier, were verified by quantitative real-time polymerase chain reaction (qRT-PCR). +circulation_biomarker_diagnosis_up 32549330 hsa-mir-146a Neurodegenerative Diseases MicroRNAs miR-146a-5p (up in cervical spinal cord) and miR3p (down in cervical spinal cord, cerebellum and plasma), both indicated in neurodegenerative diseases earlier, were verified by quantitative real-time polymerase chain reaction (qRT-PCR). +lncRNA target 32549181 hsa-mir-154 Mouth Neoplasms Collectively, our present study suggested that HDAC1 can promote the growth and progression of OSCC via regulation of miR5p/PCNA signals. +circulation_biomarker_diagnosis_ns 32548991 hsa-mir-374b Osteoporosis In the present study, we found elevated circulating miR-374b-5p level associated with postmenopausal osteoporosis. Collectively, circulating miR-374b-5p in the serum might serve as a potential diagnostic and therapeutic strategy for osteoporosis. +circulation_biomarker_diagnosis_ns 32548243 hsa-mir-126 Cardiac Allograft Vasculopathy Recently, serum-derived miR +other 32548241 hsa-mir-23b Pneumonia 5p were upregulated at T2 in patients with AR. +other 32548241 hsa-mir-148b Aortic Valve Insufficiency 3p expression levels were significantly associated with a shorter time to AR either within the first year after LTx or during follow-up. +other 32548241 hsa-mir-23b Aortic Valve Insufficiency 5p were upregulated at T2 in patients with AR. +other 32548241 hsa-let-7f Pneumonia 5p were upregulated at T2 in patients with AR. +other 32548241 hsa-mir-744 Aortic Valve Insufficiency 3p expression levels were significantly associated with a shorter time to AR either within the first year after LTx or during follow-up. +other 32548241 hsa-let-7f Aortic Valve Insufficiency 5p were upregulated at T2 in patients with AR. +other 32548241 hsa-mir-452 Aortic Valve Insufficiency 5p were upregulated at T2 in patients with AR. +other 32548241 hsa-mir-452 Pneumonia 5p were upregulated at T2 in patients with AR. +other 32548241 hsa-mir-22 Aortic Valve Insufficiency 5p were upregulated at T2 in patients with AR. +other 32548241 hsa-mir-362 Pneumonia 5p were upregulated at T2 in patients with AR. +other 32548241 hsa-mir-362 Aortic Valve Insufficiency 5p were upregulated at T2 in patients with AR. +other 32548241 hsa-mir-29c Aortic Valve Insufficiency 5p were upregulated at T2 in patients with AR. +other 32548241 hsa-mir-29c Pneumonia 5p were upregulated at T2 in patients with AR. +other 32548241 hsa-mir-146b Aortic Valve Insufficiency 5p were upregulated at T2 in patients with AR. +other 32548241 hsa-mir-146b Pneumonia 5p were upregulated at T2 in patients with AR. +other 32548241 hsa-mir-22 Pneumonia 5p were upregulated at T2 in patients with AR. +genetics_GWAS 32548059 hsa-mir-499 Arthritis, Rheumatoid METHODS: Polymorphism in miR146 and miR499 using ARMS-PCR was genotyped on 139 autoimmune disease (AD) patients (89 RA and 50 SLE) referred to Educational Hospitals of Khorramabad, Lorestan Province, west of Iran in 2018-2019 and 237 healthy control subjects. +genetics_GWAS 32548059 hsa-mir-146 Arthritis, Rheumatoid CONCLUSION: Genetic polymorphisms of miR146 rs2910164 is associated with RA susceptibility especially in females. +lncRNA target 32547733 hsa-mir-155 Reperfusion Injury, Pulmonary Ischemia Our data suggest that blocking microRNA-155 signal pathways plays a beneficial role in regulating LIRI via inhibiting responses of neuroinflammation and oxidative stress signal pathways to LIRI. +target gene 32547708 hsa-mir-206 Breast Neoplasms Specifically, miR-206 up-regulation and anti-miR-30c down-regulation act as suppressors in breast cancer cells. +circulation_biomarker_diagnosis_up 32547558 hsa-mir-200a Neuromyelitis Optica 3p and hsa-miR-200a-5p were significantly upregulated in the serum exosome of relapsing NMOSD compared with that in remitting NMOSD. +circulation_biomarker_diagnosis_up 32547558 hsa-mir-122 Neuromyelitis Optica 3p and hsa-miR-200a-5p were significantly upregulated in the serum exosome of relapsing NMOSD compared with that in remitting NMOSD. +lncRNA target 32547537 hsa-mir-125a Inflammatory Bowel Diseases Conclusion: Lnc-ITSN1-2 correlates with increased disease risk, activity, and inflammatory cytokines of IBD, and promotes IBD CD4(+) T cell activation, proliferation, and Th1/Th17 cell differentiation by serving as a competing endogenous RNA for IL-23R via sponging miR-125a. +other 32547335 hsa-mir-664 Skin Diseases BACKGROUND: MiR-664 has been demonstrated to play an important role in dermal diseases. +lncRNA target 32547334 hsa-mir-527 Esophageal Squamous Cell Carcinoma In our study, we found that miR-527 was an upregulated expression in human esophageal squamous cell carcinoma (ESCC) cells and tissues. In summary, we concluded that miR-527 acted as an oncogenic microRNA in ESCC development by directly targeting PHLPP2 might be a novel therapeutic target for the treatment of ESCC. +genetics_GWAS 32547322 hsa-mir-10a Leukemia, Myeloid, Acute Furthermore, miR-10a-3p, a novel oncogene, might involve in the development of FLT3 mutation adult AML by targeting SLC14A1, ARHGAP5 and PIK3CA. +target gene 32547232 hsa-mir-133b Uterine Cervical Neoplasms LINC02381 Promoted Cell Viability and Migration via Targeting miR-133b in Cervical Cancer Cells. +other 32547230 hsa-mir-24 Nasopharyngeal Carcinoma 3p/IL-6 axis in cell growth and MDR in NPC, which might be a potential prognostic and diagnostic marker in NPC patients and provide new insight into the molecular mechanism of MDR in NPC chemotherapy. +lncRNA target 32547228 hsa-mir-211 Uterine Cervical Neoplasms 5p to release SOX4, which might provide a potential therapeutic target for tumor treatment. +genetics_overexpression_promote 32547227 hsa-mir-9 Carcinoma, Hepatocellular CONCLUSION: Overexpression of CircMTO1 acts as tumor suppressor in liver cancer by sponging miR +circulation_biomarker_diagnosis_up 32547226 hsa-mir-28 Carcinoma, Hepatocellular DIO3OS, localized in the cytoplasm, inhibited the occurrence of HCC by disrupting the Hh pathway by sponging miR-328 to mediate Hh interacting protein (Hhip). CONCLUSION: All in all, the obtained data suggested that DIO3OS interacted with Hhip-dependent Hh signaling pathway to inhibit HCC progression through binding to miR-328, which may be a potent therapeutic target for HCC. +therapeutic target 32547223 hsa-mir-130a Stomach Neoplasms Targeted Inhibition of CCL22 by miR-130a-5p Can Enhance the Sensitivity of Cisplatin-Resistant Gastric Cancer Cells to Chemotherapy. +genetics_overexpression_promote 32547220 hsa-mir-221 Carcinoma, Non-Small-Cell Lung In NSCLC cells, overexpression of LEF1-AS1 led to downregulated expression of PTEN but upregulated expression of miR-221, which can directly target PTEN. +genetics_knock down_promote 32547214 hsa-mir-342 Ovarian Neoplasms MiR-342-5p targeted gene is CBX2, which can significantly reduce the proliferation, invasion, migration and viability of ovarian cancer cell lines SKOV3 and OVCAR3, and promote their apoptosis. +genetics_knock down_promote 32547213 hsa-mir-149 Carcinoma, Hepatocellular 5p overexpression on proliferation, migration and invasion in HCC cells. +other 32547198 hsa-mir-1301 Uterine Cervical Neoplasms 3p to promote RHEB expression, which resulted in mTOR signaling activation and CC cell malignant growth. +transcription factor target 32547110 hsa-mir-486 Carcinoma, Endometrioid 5p as a novel molecular biomarker for diagnosing and treating EC, and MARK1 might act as a critical and functional target of miR +other 32547107 hsa-mir-524 Breast Neoplasms CONCLUSION: TTN-AS1 exerts oncogenic function in BC by repressing miR5p and increasing the expression of RRM2. +other 32547106 hsa-mir-2682 Triple Negative Breast Neoplasms Circular RNA hsa_circ_0131242 Promotes Triple-Negative Breast Cancer Progression by Sponging hsa-miR-2682. +lncRNA target 32547105 hsa-mir-335 Nasopharyngeal Carcinoma We provided evidence that ZNRD1-AS1 facilitates the invasion and metastasis of NPC cells via the miR +genetics_overexpression_suppress 32547104 hsa-mir-124 Chordoma 3p inhibitor or mimic reversed the effects induced by lncRNA XIST silencing or overexpression on chordoma cell proliferation. +target gene 32547102 hsa-mir-877 Stomach Neoplasms miR-877-5p Suppresses Gastric Cancer Cell Proliferation Through Targeting FOXM1. +lncRNA target 32547091 hsa-mir-199a Carcinoma, Non-Small-Cell Lung CONCLUSION: Altogether, the findings suggested that the up-regulation of miR-199a-3p significantly inhibited NSCLC growth in vivo, and reduced A549 cell proliferation and promoted mitochondrial-mediated apoptosis, through down-regulation of ZEB1. +target gene 32547090 hsa-mir-9 Osteosarcoma Long Non-Coding RNA 691 Regulated PTEN/PI3K/AKT Signaling Pathway in Osteosarcoma Through miRNA-9-5p. +other 32547087 hsa-mir-877 Squamous Cell Carcinoma of Head and Neck 5p and upregulating FOXP4. +other 32547085 hsa-mir-338 Prostatic Neoplasms CircHIPK3 Facilitates the G2/M Transition in Prostate Cancer Cells by Sponging miR-338-3p. +other 32547084 hsa-mir-409 Stomach Neoplasms Circ_0001023 Promotes Proliferation and Metastasis of Gastric Cancer Cells Through miR-409-3p/PHF10 Axis. +genetics_overexpression_promote 32547082 hsa-mir-1283 Carcinoma, Hepatocellular Furthermore, overexpression of miR-1283 abolished the promotion of circGprc5a on HCC cells. +target gene 32547080 hsa-mir-181c cervical squamous cell carcinoma MiR-181c-5p Mitigates Tumorigenesis in Cervical Squamous Cell Carcinoma via Targeting Glycogen Synthase Kinase 3β Interaction Protein (GSKIP). +genetics_overexpression_promote 32547079 hsa-mir-381 Squamous Cell Carcinoma of Head and Neck RESULTS: miR-381 was observed to be greatly down-regulated in HNSCC cells, and its overexpression could inhibit cell proliferation, migration and invasion. +lncRNA target 32547074 hsa-mir-624 Carcinoma, Hepatocellular CONCLUSION: Collectively, ZFAS1 depletion inhibited the occurrence of HCC by downregulating the MDK/ERK/JNK/P38 pathway through restoring miR-624 expression. +target gene 32547067 hsa-mir-1193 Uterine Cervical Neoplasms MiR-1193 Inhibits the Malignancy of Cervical Cancer Cells by Targeting Claudin 7 (CLDN7). +lncRNA target 32547064 hsa-mir-383 Glioma The aim of the present study was to identify the role of long non-coding RNA LINC01614 (LINC01614) in glioma development and explore the underlying mechanisms of LINC01614/miR-383/ADAM12 axis. CONCLUSION: Overall, these findings showed that SP1-induced upregulation of LINC01614 promoted glioma malignant progression via modulating the miR-383/ADAM12 axis, which may provide a promising therapy for glioma. +genetics_overexpression_promote 32547062 hsa-mir-132 Colorectal Neoplasms 3p, and its overexpression restored the inhibition effect of miR +target gene 32547057 hsa-mir-3174 Urinary Bladder Neoplasms The microRNA miR-3174 Suppresses the Expression of ADAM15 and Inhibits the Proliferation of Patient-Derived Bladder Cancer Cells. +lncRNA target 32547033 hsa-mir-155 Epilepsy 5p plays a key proinflammatory role and thus represents a promising target for inflammatory modulation in epilepsy pathologies. +transcription factor target 32546967 hsa-mir-19a Ischemic Stroke Rescue experiments demonstrated that glycine improved cell apoptosis, inflammatory response and glucose metabolism disorder of ischemic stroke through miR-19a-3p/AMPK/GSK-3beta/HO-1 pathway. CONCLUSION: Glycine improves ischemic stroke through miR-19a-3p/AMPK/GSK-3beta/HO-1 pathway. +other 32546573 hsa-mir-27a Lung Injury CONCLUSIONS: Our data support involvement of miR-27a-5p and VAV3 in cellular adhesion and infiltration during acute lung injury and a potential role for miR-27a-based therapeutics for acute respiratory distress syndrome. +other 32546573 hsa-mir-27a Sepsis CONCLUSIONS: Our data support involvement of miR-27a-5p and VAV3 in cellular adhesion and infiltration during acute lung injury and a potential role for miR-27a-based therapeutics for acute respiratory distress syndrome. +circulation_biomarker_diagnosis_ns 32546033 hsa-mir-29c Parkinson Disease OBJECTIVES: To determine the serum expression levels of seven candidate microRNAs (miRNA); miR-19a, miR-19b, miR-29a, miR-29c, miR-181, miR-195 and miR-221 in Turkish patients with Parkinson's disease (PD) and explored their potential role in the diagnosis of PD. CONCLUSION: This study suggests that serum miR-29c expression level might be potential biomarker in the diagnosis of Turkish Parkinson patients. +circulation_biomarker_diagnosis_ns 32545709 hsa-mir-6513 Lymphoma The altered serum miRNAs may discriminate VRL from uveitis, and serum miR +lncRNA target 32545591 hsa-mir-200a ACTH-Secreting Pituitary Adenoma Accordingly, the expression of miR-375, miR-383, miR-488, miR-200a and miR-103; of PKA, MAP3K8, MEK, MAPK3, NGFIB, NURR1, PITX1, and STAT3 were analyzed via qRT-PCR in 23 silent and 24 functioning CTs. miR-200a and miR-103 showed significantly higher expression in silent than in functioning CTs, even after eliminating the bias of tumor size, therefore enabling the differentiation between the two variants. +lncRNA target 32545591 hsa-mir-103 ACTH-Secreting Pituitary Adenoma Accordingly, the expression of miR-375, miR-383, miR-488, miR-200a and miR-103; of PKA, MAP3K8, MEK, MAPK3, NGFIB, NURR1, PITX1, and STAT3 were analyzed via qRT-PCR in 23 silent and 24 functioning CTs. miR-200a and miR-103 showed significantly higher expression in silent than in functioning CTs, even after eliminating the bias of tumor size, therefore enabling the differentiation between the two variants. +other 32545591 hsa-mir-488 ACTH-Secreting Pituitary Adenoma Finally, the gene expression levels of miR-488, miR-200a, and miR-103 were significantly higher in macroadenomas (functioning and silent) than in microadenomas. +other 32545233 hsa-mir-363 Pulmonary Embolism 3p (AUC = 0.78; 95% Confidence Interval (CI) [0.63, 0.94]) and another with cfDNA and myeloperoxidase as predictors (AUC = 0.71; 95%CI [0.52, 0.90]). +other 32545233 hsa-mir-363 Brain Neoplasms 3p (AUC = 0.78; 95% Confidence Interval (CI) [0.63, 0.94]) and another with cfDNA and myeloperoxidase as predictors (AUC = 0.71; 95%CI [0.52, 0.90]). +other 32545233 hsa-mir-23a Pulmonary Embolism 5p, miR-23a-3p and miR-23b-3p (AUC = 0.69; 95%CI [0.52, 0.87]). +other 32545233 hsa-mir-93 Brain Neoplasms 3p (AUC = 0.78; 95% Confidence Interval (CI) [0.63, 0.94]) and another with cfDNA and myeloperoxidase as predictors (AUC = 0.71; 95%CI [0.52, 0.90]). +other 32545233 hsa-mir-140 Brain Neoplasms 3p (AUC = 0.78; 95% Confidence Interval (CI) [0.63, 0.94]) and another with cfDNA and myeloperoxidase as predictors (AUC = 0.71; 95%CI [0.52, 0.90]). +other 32545233 hsa-mir-660 Brain Neoplasms 5p, miR-23a-3p and miR-23b-3p (AUC = 0.69; 95%CI [0.52, 0.87]). +other 32545233 hsa-mir-29a Brain Neoplasms 5p, miR-23a-3p and miR-23b-3p (AUC = 0.69; 95%CI [0.52, 0.87]). +other 32545233 hsa-mir-660 Pulmonary Embolism 5p, miR-23a-3p and miR-23b-3p (AUC = 0.69; 95%CI [0.52, 0.87]). +other 32545233 hsa-mir-451a Pulmonary Embolism 3p (AUC = 0.78; 95% Confidence Interval (CI) [0.63, 0.94]) and another with cfDNA and myeloperoxidase as predictors (AUC = 0.71; 95%CI [0.52, 0.90]). +other 32545233 hsa-mir-451a Brain Neoplasms 3p (AUC = 0.78; 95% Confidence Interval (CI) [0.63, 0.94]) and another with cfDNA and myeloperoxidase as predictors (AUC = 0.71; 95%CI [0.52, 0.90]). +other 32545233 hsa-mir-29a Pulmonary Embolism 5p, miR-23a-3p and miR-23b-3p (AUC = 0.69; 95%CI [0.52, 0.87]). +other 32545233 hsa-mir-93 Pulmonary Embolism 3p (AUC = 0.78; 95% Confidence Interval (CI) [0.63, 0.94]) and another with cfDNA and myeloperoxidase as predictors (AUC = 0.71; 95%CI [0.52, 0.90]). +other 32545233 hsa-mir-23a Brain Neoplasms 5p, miR-23a-3p and miR-23b-3p (AUC = 0.69; 95%CI [0.52, 0.87]). +other 32545233 hsa-mir-140 Pulmonary Embolism 3p (AUC = 0.78; 95% Confidence Interval (CI) [0.63, 0.94]) and another with cfDNA and myeloperoxidase as predictors (AUC = 0.71; 95%CI [0.52, 0.90]). +exosome 32544403 hsa-mir-21 Buschke-Ollendorff syndrome Subsequently, we demonstrated that extracellular vesicles (EVs) isolated from M2 TAMs containing oncomiR-21 and mRNAs, including Akt, STAT3, mTOR, and beta-catenin, promoted cisplatin (CDDP) resistance, migration, and tumor-sphere generation in BCa cells, through increasing CDK6, mTOR, STAT3, and beta-catenin expression. +genetics_knock down_promote 32544377 hsa-mir-762 Retinitis Pigmentosa Furthermore, the knockdown of miR-762 upregulated NPDC1 expression in RPCs, leading to the inhibition of RPC proliferation and the increase in neuronal differentiation. +other 32544168 hsa-mir-16 Meier-Gorlin syndrome 5p, has-miR-27b-3p, has-miR-29c-3p, and KCNQ1OT1 were crucial nodes with high degrees of connectivity. +other 32544168 hsa-mir-27b Meier-Gorlin syndrome 5p, has-miR-27b-3p, has-miR-29c-3p, and KCNQ1OT1 were crucial nodes with high degrees of connectivity. +other 32544168 hsa-mir-424 Meier-Gorlin syndrome 5p, has-miR-27b-3p, has-miR-29c-3p, and KCNQ1OT1 were crucial nodes with high degrees of connectivity. +other 32544168 hsa-mir-29c Meier-Gorlin syndrome 5p, has-miR-27b-3p, has-miR-29c-3p, and KCNQ1OT1 were crucial nodes with high degrees of connectivity. +transcription factor target 32544097 hsa-mir-183 Cardiovascular Diseases These findings identify miR-96 and miR-183 as regulators of neovascularization following MI and miR-regulated genes, such as anillin, as potential therapeutic targets for cardiovascular disease. +transcription factor target 32544097 hsa-mir-96 Myocardial Infarction These findings identify miR-96 and miR-183 as regulators of neovascularization following MI and miR-regulated genes, such as anillin, as potential therapeutic targets for cardiovascular disease. +transcription factor target 32544097 hsa-mir-183 Myocardial Infarction These findings identify miR-96 and miR-183 as regulators of neovascularization following MI and miR-regulated genes, such as anillin, as potential therapeutic targets for cardiovascular disease. +transcription factor target 32544097 hsa-mir-96 Cardiovascular Diseases Moreover, ANLN expression inversely correlated with miR-96 expression and age in cardiac ECs of cardiovascular patients. These findings identify miR-96 and miR-183 as regulators of neovascularization following MI and miR-regulated genes, such as anillin, as potential therapeutic targets for cardiovascular disease. +genetics_overexpression_promote 32543927 hsa-mir-877 Stomach Neoplasms Overexpression of AQP3 partially rescued the tumor suppressive effects of miR-877 in GC cells. +genetics_GWAS 32543775 hsa-mir-18a Breast Neoplasms In this study we have explored the epigenetic regulation of estrogen receptor (ER)-dependent molecular and cellular phenotype by hsa-miR-18a-5p using well-established human ER-positive (ER+) breast cancer cell lines. +genetics_GWAS 32543749 hsa-mir-582 Leukemia, Myeloid, Acute 5p in predicting the prognosis and promoting the tumor growth of AML. +genetics_GWAS 32543749 hsa-mir-582 Leukemia 5p in predicting the prognosis and promoting the tumor growth of AML. +lncRNA target 32543324 hsa-mir-4262 Glioma Collectively, our findings unveiled that LINC00641 serves as a tumor inhibitor in glioma by targeting miR-4262/NRGN axis, providing a new potential therapeutic target for glioma patients. +lncRNA target 32542845 hsa-mir-10a Pancreatic Carcinoma Our study provided evidence that miR-10a inhibition reduced EMT and stemness maintenance of PCSCs via upregulating WWC2 expression and inhibiting the Hippo signaling pathway. +genetics_overexpression_suppress 32542696 hsa-mir-448 Diabetic Angiopathies 3p overexpression inhibits EndMT via targeting DPP-4 and further ameliorates diabetic vascular endothelial dysfunction, indicating that miR +genetics_overexpression_suppress 32542430 hsa-mir-466c Spinal Cord Injuries Transfection with miR-466c-3p mimics caused overexpression of miR-466c-3p, also improvement in functional recovery, decrease in apoptosis of neuronal cells and lesion size was observed in SCI rats. +transcription factor target 32542340 hsa-mir-21 Lung Diseases Through LC-MS/MS analysis, we discover that majority of miR5p isolated from human non-small cell lung cancer (NSCLC) tissue possesses 3'-terminal 2'Ome. +lncRNA target 32542098 hsa-mir-133a Retinoblastoma CONCLUSIONS: Our results reveal that miR-133a-3p exhibits anti-cancer effects by targeting CREB1 in RB. +target gene 32542094 hsa-mir-1179 Ovarian Neoplasms MicroRNA-1179 regulates proliferation and chemosensitivity of human ovarian cancer cells by targeting the PTEN-mediated PI3K/AKT signaling pathway. +genetics_overexpression_promote 32542092 hsa-mir-345 Thyroid Cancer, Papillary Furthermore, overexpression of SETD7 attenuated the miR +genetics_overexpression_promote 32542091 hsa-mir-376c Thyroid cancer, medullary Results for the luciferase reporter assay showed that miR-376c-3p was able to bind the 3' untranslated region of heparin-binding EGF-like growth factor (HBEGF), of which overexpression nearly nullified the miR-376c-3p mimic-induced inhibitory effects in the MTC cells. +genetics_overexpression_promote 32541994 hsa-mir-205 Carcinoma, Endometrioid MiR-141/200a/205 overexpressed in endometrial carcinomas and miR-141/200a might behave differently between these two ethnic groups as well as in EEC and in NEEC. +transcription factor target 32541994 hsa-mir-143 Carcinoma, Endometrioid Although miR-145/143 showed inverse expression patterns between Uygur and Han women with endometrial cancer, they all exerted tumor suppression effect on endometrial cancer. +transcription factor target 32541994 hsa-mir-145 Carcinoma, Endometrioid Although miR-145/143 showed inverse expression patterns between Uygur and Han women with endometrial cancer, they all exerted tumor suppression effect on endometrial cancer. +circulation_biomarker_diagnosis_up 32541886 hsa-mir-326 Lymphoma, B-Cell The most strongly induced (miR-326) and suppressed (miR-375) plasma microRNA at diagnosis, when compared with healthy blood donors, were also substantially up- or down-regulated in plasma repository samples taken from several months to up to two years before the blood donors were diagnosed with B-cell lymphoma. +circulation_biomarker_diagnosis_up 32541886 hsa-mir-375 Lymphoma, B-Cell The most strongly induced (miR-326) and suppressed (miR-375) plasma microRNA at diagnosis, when compared with healthy blood donors, were also substantially up- or down-regulated in plasma repository samples taken from several months to up to two years before the blood donors were diagnosed with B-cell lymphoma. +lncRNA target 32541687 hsa-mir-181c Diabetes Mellitus, Type 1 These results suggest that miR-181c-5p is critically involved in pancreatic lineage commitment through direct repression of smad7 and TGIF2 and that it modulates TGF-beta-smad2/3 signaling activation and increases the feasibility of using patient-specific hiPSCs for beta cell replacement therapy for type 1 diabetes. +lncRNA target 32541687 hsa-mir-181c Diabetes Mellitus These results suggest that miR-181c-5p is critically involved in pancreatic lineage commitment through direct repression of smad7 and TGIF2 and that it modulates TGF-beta-smad2/3 signaling activation and increases the feasibility of using patient-specific hiPSCs for beta cell replacement therapy for type 1 diabetes. +genetics_knock down_promote 32541644 hsa-mir-613 Retinoblastoma Importantly, knockdown of LINC00152-induced effects on retinoblastoma cells could be overturned by introducing miR-613 inhibitor. +circRNA target 32541093 hsa-mir-498 Carcinoma, Renal Cell Finally, functional studies revealed that inhibition of hsa_circ_0085576 suppressed cell growth and metastasis by regulating miR-498/YAP1 signaling, in ccRCC cells. +genetics_overexpression_promote 32541092 hsa-mir-182 Nasopharyngeal Carcinoma Furthermore, PTEN was verified to be a target of miR-182 and overexpression of PTEN could abrogate the promotion effect of miR-182 mimics on NPC invasion. +lncRNA target 32540401 hsa-mir-150 Arthritis, Rheumatoid LINC01197 promoted THBS2 expression through miR-150 sponging and inactivated the TLR4/NF-kappaB signaling pathway, thus alleviating RA inflammation. CONCLUSION: The current study suggested that LINC01197 sponged miR-150 to promote THBS2 expression, leading to TLR4/NF-kappaB inactivation, and ameliorated RA inflammation. +genetics_knock down_promote 32540398 hsa-mir-193a Colonic Neoplasms The functional roles of miR-193a and FAK in colon cancer were determined using loss- and gain-function experiments. +lncRNA target 32540374 hsa-mir-760 Polycystic Ovary Syndrome Firstly, we found that miR-760 expression was decreased in PCOS tissues insulin treated GCs, KGN and SVOG cells. Collectively, our findings suggest that circPUM1 promotes PCOS progression through sponging to miR-760. +transcription factor target 32539925 hsa-mir-520c Lung Injury In conclusion, miR-520c-3p alleviates LPS-induced inflammatory injury via regulating NLRC5. +transcription factor target 32539924 hsa-mir-342 Myocardial Reperfusion Injury 5p may be a potential target for MI/R injury prevention and therapy of MI/R injury. +other 32539923 hsa-mir-7 Thyroid Cancer, Papillary 5p appears to be associated with the aggressiveness of PTC. +other 32539923 hsa-mir-451 Thyroid Cancer, Papillary Quantitative real-time PCR (qRT-PCR) was performed to detect the expression levels of miR5p and miR-451 in 101 PTC tissues and in 40 nodular goiter tissues (controls). +transcription factor target 32539181 hsa-mir-7a Diabetic Nephropathies In conclusion, butyrate alleviated DKD by mediating the miR-7a-5p/P311/TGF-beta1 pathway. +circulation_biomarker_diagnosis_up 32539131 hsa-let-7a Retinoblastoma Next, in order to explore effects of let-7a and MST4 on RB cellular functions, RB cells were transfected with let-7a-mimic, let-7a inhibitor, si-MST4, or co-transfected with let-7a-mimic and oe-MST4 plasmids. +other 32538770 hsa-mir-338 Carcinoma, Hepatocellular QRT-PCR was used to detect the levels of lncRNA KCNQ1OT1 and miR3p in normal hepatocyte HH01, hepatocellular cell SK-HEP-1 and hepatoma cisplatin-resistant cell SK-HEP-1/DDP. +other 32538764 hsa-mir-196b Carcinoma, Hepatocellular The purpose of this study was to investigate the effects of microRNA-196b (miRNA-196b) on proliferation, migration, invasiveness and apoptosis of hepatocellular carcinoma cell line (HepG2), and the mechanism involved. +lncRNA target 32538761 hsa-mir-410 Osteosarcoma Inhibition of LncRNA NORAD expression can inhibit the proliferation of osteosarcoma HOS/DDP cells through targeted regulation of miR +circulation_biomarker_diagnosis_up 32538753 hsa-mir-383 Pre-Eclampsia Blood pressure, miR-383, miR-16 at the admission of pregnant women were independent risk factors for severe preeclampsia. +other 32538751 hsa-mir-27a Pulmonary Fibrosis Up-regulation of miR-27a-3p expression can effectively improve the disease degree and inflammatory response in rats with pulmonary fibrosis. +circulation_biomarker_prognosis_up 32538743 hsa-mir-92b Squamous Cell Carcinoma of Head and Neck Multivariate Cox regression exhibited that TNM staging, lymph node metastasis, and serum miR-92b expression were self-regulating risk factors for overall survival (OS) and disease-free survival (DFS) in patients with advanced OSCC. +genetics_knock down_promote 32538668 hsa-mir-340 Squamous Cell Carcinoma of Head and Neck In conclusion, knockdown of SNHG3 inhibited LSCC progression via inactivating Wnt/beta-catenin pathway by regulating the miR +other 32538667 hsa-mir-18a Stomach Neoplasms We found that GAS5 expression was downregulated while miR-18a expression was upregulated in primary NK cells isolated from GC patient compared with the healthy controls. In conclusion, GAS5 promotes the killing effect of the natural killer cells against GC by regulating miR-18a, providing promising strategies for NK cells based antitumor therapies. +genetics_knock down_suppress 32538666 hsa-mir-485 Ovarian Neoplasms 5p mimics can inhibit the proliferation, migration, invasion, and the induction of cycle arrest and apoptosis of SKOV3 cells in vivo and in vitro, and pcDNA-SRC can reverse the effect of miR +genetics_knock down_promote 32538587 hsa-mir-653 Wilms Tumor Knockdown of LINC00858 suppresses Wilms' tumor cells to proliferate and migrate via targeting miR +genetics_knock down_promote 32538432 hsa-mir-433 Breast Neoplasms 3p overexpression or GATA3 knockdown impaired the effects of GNAS-AS1 on M2 macrophage polarization and ER+ breast cancer cells progression. +other 32538237 hsa-mir-181a Cardiomyopathies Subsequently, immunohistochemical and molecular studies suggested that the downregulation of miR-181a resulted in the attenuation of myocardial fibrosis and hypertrophy, restoring the injured rodent heart after myocardial infarction. +other 32538237 hsa-mir-181a Myocardial Infarction Subsequently, immunohistochemical and molecular studies suggested that the downregulation of miR-181a resulted in the attenuation of myocardial fibrosis and hypertrophy, restoring the injured rodent heart after myocardial infarction. +circulation_biomarker_diagnosis_down 32538067 hsa-mir-127 Stomach Neoplasms 3p were downregulated in the plasma of GC patients that may participate in the pathological process of GC and act as potential tumor biomarkers. +circulation_biomarker_diagnosis_down 32538067 hsa-mir-144 Stomach Neoplasms 3p were downregulated in the plasma of GC patients that may participate in the pathological process of GC and act as potential tumor biomarkers. +circulation_biomarker_diagnosis_up 32538061 hsa-mir-148 Inflammatory Bowel Diseases CONCLUSIONS: In summary, enhanced expression of miR-148 in peripheral blood of UC patients may be expected to be an index for evaluating the activity of UC disease. +circulation_biomarker_diagnosis_up 32538057 hsa-mir-210 Hypertension, Pulmonary CONCLUSIONS: MiR-210 was up-regulated in plasma of patients with COPD included PH, and miR-210 may serve as an early diagnostic marker for the disease. +circulation_biomarker_diagnosis_up 32538057 hsa-mir-210 Pulmonary Disease, Chronic Obstructive CONCLUSIONS: MiR-210 was up-regulated in plasma of patients with COPD included PH, and miR-210 may serve as an early diagnostic marker for the disease. +circulation_biomarker_prognosis_ns 32538053 hsa-mir-142 Myocardial Infarction, Acute RESULTS: miR-142 expression was markedly elevated in serum samples of AMI patients compared with the 83 non-AMI healthy controls. +other 32538052 hsa-mir-409 Leukemia, Myeloid, Acute 3p expression level could be a novel potential biomarker for acute myeloid leukemia diagnosis and prognosis, providing a new therapeutic strategy for acute myeloid leukemia treatment. +circulation_biomarker_prognosis_up 32538049 hsa-mir-145 Leukemia, Myeloid, Acute CONCLUSIONS: The level of miR-145 in serum and BMNc of AML patients was significantly lower than those of the control group. +circulation_biomarker_prognosis_ns 32538046 hsa-mir-15b Carcinoma, Non-Small-Cell Lung The serum levels of miR-125b and miR-15b in patients with advanced NSCLC before treatment may be used to estimate the overall survival. +other 32537941 hsa-mir-377 Osteosarcoma 3p in osteosarcoma. +circulation_biomarker_diagnosis_ns 32537885 hsa-mir-4661 Carcinoma, Hepatocellular 5p-based serum panel is a promising diagnostic marker for early-stage HCC. +circRNA target 32537647 hsa-mir-545 Osteosarcoma In addition, hsa_circ_0003732 could elevate CCNA2 expression via miR-545, resulting in the promotion of OS cells proliferation. Altogether, our findings demonstrate that hsa_circ_0003732 promotes OS cells proliferation via miR-545/CCNA2 axis and imply hsa_circ_0003732 may be a potential prognosis biomarker and therapeutic target for OS. +transcription factor target 32537629 hsa-mir-31 Carcinoma, Hepatocellular 3p in HCC through weighted gene coexpression network analysis (WGCNA) based on The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) and Oncomine. +lncRNA target 32537433 hsa-mir-33a Glioblastoma Our results demonstrated a novel role for the PD-L1 inhibitor in inducing radio- sensitivity in GBM cells, where inhibiting miR-33a-5p, leading to PTEN activated, and inducing DNA damage was crucial for antitumor immunotherapies to treat GBM. +target gene 32537015 hsa-mir-513a Colorectal Neoplasms MicroRNA-513a-3p regulates colorectal cancer cell metabolism via targeting hexokinase 2. +circulation_biomarker_diagnosis_up 32537006 hsa-mir-338 Hypertension, Pregnancy-Induced 3p is significantly increased in the peripheral blood and placenta of PIH patients, which is correlated with the disease development. +lncRNA target 32536914 hsa-mir-128 Pancreatic Carcinoma Through in vivo experiments, we found that miR-128 could suppress the growth and metastasis of PDAC. +target gene 32536825 hsa-mir-454 Ovarian Neoplasms miR-454 suppresses the proliferation and invasion of ovarian cancer by targeting E2F6. +other 32536824 hsa-mir-338 Neuroblastoma SNHG16 promotes tumorigenesis and cisplatin resistance by regulating miR-338-3p/PLK4 pathway in neuroblastoma cells. +genetics_knock down_promote 32536822 hsa-mir-195 Carcinoma, Hepatocellular Further research on mechanism suggested that loss of inhibition of hsa-miR3p and dysregulation of UBE2I promoter methylation might account for UBE2I overexpression in HCC. +lncRNA target 32536820 hsa-mir-4656 Carcinoma, Hepatocellular CONCLUSION: In conclusion, our findings suggested that ST8SIA6-AS1 was a novel upregulated lncRNA in HCC and could facilitate cell proliferation and resistance to cell apoptosis via sponging miR-4656 and elevation of HDAC11, which might be a promising biomarker for patients with HCC. +genetics_knock down_promote 32536815 hsa-mir-363 Carcinoma, Renal Cell The mechanism of miR-363 on the proliferation, migration and invasion of ccRCC was determined by gain- and loss-of-function analyses. +circulation_biomarker_prognosis_up 32536234 hsa-mir-92a Leukemia, Myeloid, Acute This prospective study assessed circulating miR-92a levels in acute myeloid leukemia (AML) at diagnosis and after induction therapy and followed patients for a maximum of 30 months. In conclusion, baseline circulating miR-92a in AML patients may be a useful prognostic marker of treatment response and survival over 2.5 years follow up. +circulation_biomarker_diagnosis_up 32536220 hsa-mir-146a Obesity miRNA and CD36 expression was measured by real-time RT-PCR, respectively, in serum and blood.Results: miR-146a and miR-21 concentrations were significantly decreased; however, CD36 expression was increased in obese subjects. +circulation_biomarker_diagnosis_up 32536220 hsa-mir-21 Obesity miRNA and CD36 expression was measured by real-time RT-PCR, respectively, in serum and blood.Results: miR-146a and miR-21 concentrations were significantly decreased; however, CD36 expression was increased in obese subjects. +lncRNA target 32536202 hsa-mir-892a Laryngeal Neoplasms These findings demonstrated that miR-892a acted as an LC oncogene via its action on Dicer, which further confirmed that miR-892a can serve as a diagnostic indicator or promising agent for LC treatment. +genetics_knock down_promote 32536099 hsa-mir-223 Stomach Neoplasms miR-223 knockdown in macrophage reversed the migration and invasion of exosomes on gastric cancer cells(215.6+/-9.2, 402.5+/-11.6, 253.7+/-10.4, all P<0.01, and 91.5+/-8.2,263.4+/-9.3,105.8+/-9.3,all P<0.01, respectively).Functional studies revealed that exosomal miR-223 derived from macrophage promoted the metastasis of GC cells via the PTEN-PI3K/AKT pathway. +lncRNA target 32536038 hsa-mir-2355 Squamous Cell Carcinoma of Head and Neck These findings suggest that WDFY3-AS2 may participate in ESCC development and progression, and may be a novel prognostic factor for ESCC patients, and thus targeting WDFY3-AS2/miR +genetics_knock down_promote 32535745 hsa-mir-23a Myocardial Infarction, Acute HUCB-MSCs-derived exosomes inhibited ferroptosis and reduced myocardial injury, which was abolished in exosome with miR-23a-3p knockout. In conclusion, HUCB-MSCs-exosomes may suppress DMT1 expression by miR-23a-3p to inhibit ferroptosis and attenuate myocardial injury. +genetics_knock down_promote 32535745 hsa-mir-23a Cardiomyopathies HUCB-MSCs-derived exosomes inhibited ferroptosis and reduced myocardial injury, which was abolished in exosome with miR-23a-3p knockout. In conclusion, HUCB-MSCs-exosomes may suppress DMT1 expression by miR-23a-3p to inhibit ferroptosis and attenuate myocardial injury. +lncRNA target 32535704 hsa-mir-214 Heart Diseases Considering cardioprotective and microRNA modulatory effects of sildenafil, a phosphodiesterase 5 (PDE5) inhibitor, we investigated the impact of chronic alcohol consumption on cardiac expression of miR-214 and its anti-apoptotic protein target, Bcl-2 and whether sildenafil attenuates such changes. +other 32535612 hsa-mir-21 Adenocarcinoma of Lung CONCLUSIONS MiR5p exhibits the potential to act as a biomarker for the survival prognosis of lung adenocarcinoma. +lncRNA target 32535381 hsa-mir-708 Colonic Neoplasms 5p inhibitor or pcDNA3.1/CTNNB1 abolished the inhibitory impacts induced by MINCR silence in CC progression. +genetics_overexpression_promote 32535070 hsa-mir-1283 Spinal Cord Injuries RESULTS: The results showed that lncRNA-TSIX and the TP53INP2 mRNA expression levels in SCI patients was overexpressed in comparison to the control group alongside with a significant downregulation of miR-1283. +genetics_overexpression_promote 32535033 hsa-mir-384 Stomach Neoplasms The oncogenic potential of hsa-circ-0000670 in gastric cancer cells were inhibited by overexpressed miR-384. Mechanistically, SIX4 was targeted by miR-384 and was upregulated in gastric cancer. +genetics_knock down_suppress 32534959 hsa-mir-155 Cystic Fibrosis Knockdown studies using BACH1 siRNA and overexpression of miR-155 did not significantly rescue HO-1 expression in CFBE41o- cells. +lncRNA target 32534701 hsa-mir-194 Ovarian Neoplasms 5p could be a potential therapeutic target and a prognostic biomarker for ovarian cancer, with important implications for future research. +lncRNA target 32534700 hsa-mir-1224 Esophageal Squamous Cell Carcinoma 5p is a possible clinical target for ESCA. +circulation_biomarker_diagnosis_up 32534478 hsa-let-7b Pulmonary Embolism The endogenous non-coding microRNA (miRNA) let-7b-5p is highly expressed in the blood of patients with acute pulmonary embolism (PE). +genetics_overexpression_promote 32534305 hsa-mir-23a Neuroblastoma The overexpression of miR-323a-5p or miR +genetics_overexpression_promote 32534305 hsa-mir-342 Neuroblastoma The overexpression of miR-323a-5p or miR +other 32534225 hsa-mir-29c Cataract Quantitative real-time polymerase chain reaction (qRT-PCR) showed that miR-29c-3p was lowly expressed, while FBJ murine osteosarcoma viral oncogene homolog (FOS) and KCNQ1 overlapping transcript 1 (KCNQ1OT1) were highly expressed in cataract tissues and in TGF-beta2-treated SRA01/04 cells. +other 32534225 hsa-mir-29c AIDS-Related Complex However, the biological mechanism of miR-29c-3p in ARC is still undefined. In conclusion, KCNQ1OT1/miR-29c-3p/FOS axis played a vital role in the progression of ARC. +other 32534225 hsa-mir-29c Disease MicroRNA hsa_miR-29c-3p (miR-29c-3p) was implicated in many biological processes in complicated diseases. +other 32534099 hsa-mir-34c Dmd-Associated Dilated Cardiomyopathy Of these, miR-21*, miR-34c*, and miR-200c, demonstrated marked alterations, with functional clustering analysis showing they regulate genes linked to cardiac hypertrophy, cardiomyopathy, and oxidative stress, respectively. +other 32534099 hsa-mir-34c Friedreich Ataxia Of these, miR-21*, miR-34c*, and miR-200c, demonstrated marked alterations, with functional clustering analysis showing they regulate genes linked to cardiac hypertrophy, cardiomyopathy, and oxidative stress, respectively. +other 32534099 hsa-mir-21 Dmd-Associated Dilated Cardiomyopathy Of these, miR-21*, miR-34c*, and miR-200c, demonstrated marked alterations, with functional clustering analysis showing they regulate genes linked to cardiac hypertrophy, cardiomyopathy, and oxidative stress, respectively. +other 32534099 hsa-mir-21 Friedreich Ataxia Of these, miR-21*, miR-34c*, and miR-200c, demonstrated marked alterations, with functional clustering analysis showing they regulate genes linked to cardiac hypertrophy, cardiomyopathy, and oxidative stress, respectively. +other 32534099 hsa-mir-200c Friedreich Ataxia Of these, miR-21*, miR-34c*, and miR-200c, demonstrated marked alterations, with functional clustering analysis showing they regulate genes linked to cardiac hypertrophy, cardiomyopathy, and oxidative stress, respectively. +other 32534099 hsa-mir-200c Dmd-Associated Dilated Cardiomyopathy Of these, miR-21*, miR-34c*, and miR-200c, demonstrated marked alterations, with functional clustering analysis showing they regulate genes linked to cardiac hypertrophy, cardiomyopathy, and oxidative stress, respectively. +circulation_biomarker_diagnosis_ns 32534035 hsa-mir-92a Respiratory Distress Syndrome SIGNIFICANCE: Our study provides evidence that circulating serum miR-92a could act as a risk factor for sepsis-induced ARDS. +circulation_biomarker_diagnosis_ns 32534035 hsa-mir-92a Sepsis SIGNIFICANCE: Our study provides evidence that circulating serum miR-92a could act as a risk factor for sepsis-induced ARDS. +lncRNA target 32534026 hsa-mir-148a Tembusu virus This indicates that during DTMUV infection, the virus promotes the expression of SOCS1 by downregulating the expression of miR-148a-5p, while the upregulation of SOCS1 suppresses the production of type I interferon and promotes virus replication. +circulation_biomarker_diagnosis_up 32533960 hsa-mir-210 Diabetes Mellitus, Type 2 CONCLUSION: The increased expression of miR-210 in patients with T2DM may be related to the decreased number and function of EPCs in peripheral blood. +other 32533823 hsa-mir-139 Adenocarcinoma of Lung In addition, LINC00461 and has-mir-139 are 2 important regulatory network nodes in lung adenocarcinoma ceRNA. +other 32533643 hsa-let-7b Osteoporosis The aim of this study was to reveal the effect of let-7b on osteoporosis (OP). +genetics_GWAS 32533562 hsa-mir-22 Leukemia, Myeloid, Acute Serum miR-22 levels were lowest in AML patients with M4/M5 subtypes, and low serum miR-22 expression occurred more frequently in AML patients with higher white blood cell counts or poor cytogenetic risk. +circulation_biomarker_prognosis_ns 32533551 hsa-mir-199a Hypoxia-Ischemia, Brain The ROC analysis results showed the diagnostic value of serum miR-199a, and the combined detection of miR-199a, S100B and NSE could obtained the highest diagnostic accuracy in HIE newborns. +virus_miRNA 32533512 ebv-mir-BART22 stomach carcinoma EBV-miR-BART10-3p and EBV-miR-BART22 promote metastasis of EBV-associated gastric carcinoma by activating the canonical Wnt signaling pathway +virus_miRNA 32533512 ebv-mir-BART10 stomach carcinoma EBV-miR-BART10-3p and EBV-miR-BART22 promote metastasis of EBV-associated gastric carcinoma by activating the canonical Wnt signaling pathway +other 32533463 hsa-mir-194 Nervous System Diseases These findings hinted that miR5p/NXPH1 axis exerts vital functions in astrocytes activation and neuroinflammation-associated diseases. +genetics_overexpression_promote 32533103 hsa-mir-503 Colonic Neoplasms Furthermore, overexpressed miR +circRNA target 32532962 hsa-mir-4738 Carcinoma, Hepatocellular CircZNF566 is a novel tumor promoter in HCC and functions through the circZNF566/ miR +circulation_biomarker_diagnosis_ns 32532204 hsa-mir-34a Non-alcoholic Fatty Liver Disease Among the most commonly studied serum miRNAs, miRNA-34a showed moderate diagnostic accuracy for NAFLD and the lowest heterogeneity (sensitivity I2=5.73%, specificity I2=33.16%, AUROC=0.85). +lncRNA target 32532171 hsa-mir-376a Ischemic Stroke CONCLUSION: LncRNA SNHG1 depressed apoptosis and inflammation of IS cell model via inhibiting miR-376a and upregulating CBS/H(2)S signal. +lncRNA target 32531989 hsa-mir-23a Alzheimer Disease 5p showed a significant dysregulation in small NDEVs from AD patients as compared with controls (1.16 0.49 versus 7.54 2.5, p = 0.026; 9.32 2.27 versus 0.66 0.18, p <0.0001; 0.069 0.01 versus 0.5 0.1, p < 0.0001 and 2.9 1.2 versus 1.93 0.9, p < 0.05, respectively). +lncRNA target 32531989 hsa-mir-190a Alzheimer Disease 5p showed a significant dysregulation in small NDEVs from AD patients as compared with controls (1.16 0.49 versus 7.54 2.5, p = 0.026; 9.32 2.27 versus 0.66 0.18, p <0.0001; 0.069 0.01 versus 0.5 0.1, p < 0.0001 and 2.9 1.2 versus 1.93 0.9, p < 0.05, respectively). +lncRNA target 32531989 hsa-mir-223 Alzheimer Disease 5p showed a significant dysregulation in small NDEVs from AD patients as compared with controls (1.16 0.49 versus 7.54 2.5, p = 0.026; 9.32 2.27 versus 0.66 0.18, p <0.0001; 0.069 0.01 versus 0.5 0.1, p < 0.0001 and 2.9 1.2 versus 1.93 0.9, p < 0.05, respectively). +lncRNA target 32531989 hsa-mir-100 Alzheimer Disease 5p showed a significant dysregulation in small NDEVs from AD patients as compared with controls (1.16 0.49 versus 7.54 2.5, p = 0.026; 9.32 2.27 versus 0.66 0.18, p <0.0001; 0.069 0.01 versus 0.5 0.1, p < 0.0001 and 2.9 1.2 versus 1.93 0.9, p < 0.05, respectively). +other 32531327 hsa-let-7f-2 Diabetic Foot First, we analyzed the change of miRNA after NPWT or ST and observed an upregulation of let-7f-2 only in the NPWT group. +circulation_biomarker_diagnosis_down 32531321 hsa-mir-1910 Breast Neoplasms 3p in serum exosomes may serve as a novel molecular marker for breast cancer diagnosis. +transcription factor target 32531042 hsa-mir-101 Liver Neoplasms Taken together, our findings suggest a novel regulatory loop miR-101/ANXA2/EGR1 in LCSCs and may serve as potential therapeutic targets in liver cancer. +virus_miRNA 32530809 ebv-mir-BART11 Stomach Neoplasms miR-BART11 promotes tumor-associated macrophage-induced epithelial-mesenchymal transition via targeting FOXP1 in gastric cancer +lncRNA target 32530324 hsa-mir-326 Sepsis Our data identified miR-326 as a potential therapeutic target for sepsis-induced ALI. +lncRNA target 32530324 hsa-mir-326 Acute Lung Injury Our data identified miR-326 as a potential therapeutic target for sepsis-induced ALI. +circulation_biomarker_diagnosis_ns 32529742 hsa-mir-499 Myocardial Infarction, Acute CONCLUSIONS: The results showed that plasma miRNA-499 and miRNA-22 were more sensitive and specific for the diagnosis of AMI, suggesting that they can be used as potential biomarkers for clinical diagnosis of AMI. +circulation_biomarker_diagnosis_ns 32529742 hsa-mir-22 Myocardial Infarction, Acute CONCLUSIONS: The results showed that plasma miRNA-499 and miRNA-22 were more sensitive and specific for the diagnosis of AMI, suggesting that they can be used as potential biomarkers for clinical diagnosis of AMI. +other 32529739 hsa-mir-155 Adrenoleukodystrophy Herein, a biosensor for ultrasensitive miRNA-155 detection is devised based on molybdenum disulfide (MoS(2) ) modified porous anodic aluminum oxide (AAO) photoresponsive nanochannels by atomic layer deposition (ALD). +genetics_knock down_promote 32529543 hsa-mir-155 Glioma In our study, MIR155HG level was markedly higher in glioma patients than in normal controls and that poor survival was positively correlated with MIR155HG expression. Collectively, the study demonstrated that the knockdown of MIR155HG increased glioma sensitivity to TMZ by inhibiting Wnt/beta-catenin pathway activation via potently downregulating PTBP1. +genetics_overexpression_promote 32529538 hsa-mir-34a Glioblastoma In conclusion, overexpression of PSMG3-AS1 distinguishes GBM patients from patients with sarcoidosis, and PSMG3-AS1 may promote GBM cell proliferation by downregulating miR-34a through methylation. +genetics_overexpression_promote 32529538 hsa-mir-34a Sarcoidosis In conclusion, overexpression of PSMG3-AS1 distinguishes GBM patients from patients with sarcoidosis, and PSMG3-AS1 may promote GBM cell proliferation by downregulating miR-34a through methylation. +genetics_overexpression_promote 32529465 hsa-mir-645 Lymphoma, Large B-Cell, Diffuse The promoting effect of miR-645 on the proliferation of DLBCL cells was attenuated with the overexpression of DACH1. +transcription factor target 32529172 hsa-mir-96 Myositis CONCLUSION: MiRNA and mRNA profiling identified dysregulation of interferon signalling, anti-viral response and T-helper cell pathways, and indicates a possible role for miR5p regulation of ADK in pathogenesis of IIM. +lncRNA target 32528971 hsa-mir-375 Neuroendocrine Tumors In order to advance in the discrimination of neuroendocrine from non-neuroendocrine lung tumors, we tested a series of 95 surgically resected and formalin-fixed paraffin embedded lung cancer tissues, and we analyzed the expression of miR205-5p and miR375-3p via TaqMan RT-qPCR. +other 32528555 hsa-mir-27a Hypoxia CONCLUSIONS: Long noncoding RNA SOX2-OT exacerbated hypoxia-induced cardiomyocytes injury by regulating miR-27a-3p/TGFbetaR1 axis, which may provide a novel insight for heart failure treatment. +other 32528555 hsa-mir-27a Heart Failure CONCLUSIONS: Long noncoding RNA SOX2-OT exacerbated hypoxia-induced cardiomyocytes injury by regulating miR-27a-3p/TGFbetaR1 axis, which may provide a novel insight for heart failure treatment. +genetics_knock down_promote 32528301 hsa-mir-20a Arthritis, Rheumatoid CXCL9 was confirmed to be a target of miR-320a, and CXCL9 overexpression restored RA-FLS function in the presence of miR-320a. +target gene 32528231 hsa-mir-641 Osteosarcoma Circular RNA circUBAP2 regulates proliferation and invasion of osteosarcoma cells through miR-641/YAP1 axis. +lncRNA target 32528036 hsa-mir-128 Glioblastoma 3p enhanced the therapeutic effect of TMZ via inhibition of proliferation, invasion and migration of glioblastoma cells and induction of apoptosis. +lncRNA target 32528035 hsa-mir-410 Carcinoma, Non-Small-Cell Lung Therefore, miR-410 may serve as a potential biomarker or therapeutic target for NSCLC radiotherapy. +other 32527702 hsa-mir-486 Urinary Bladder Neoplasms 5p has useful results in the enhancement of cisplatin sensitivity of 5637 and EJ138 cancer cells and this combination may be a promising treatment strategy for bladder cancer therapy. +exosome 32527448 hsa-mir-155 Stomach Neoplasms Thus, our results reveal that exosomal miR +genetics_knock down_suppress 32527447 hsa-mir-137 Carcinoma, Hepatocellular miR-137 overexpression prevented HCC cell proliferation and tumor growth, while miR-137 downregulation reversed the repressing effects of HBx-siRNA on HCC cell proliferation. +circulation_biomarker_prognosis_up 32527354 hsa-mir-21 Pancreatitis Correlation analysis showed a positive correlation between the expression level of plasma miR +circulation_biomarker_prognosis_up 32527354 hsa-mir-551 Pancreatitis Correlation analysis showed a positive correlation between the expression level of plasma miR +circulation_biomarker_diagnosis_up 32527308 hsa-mir-101 Pre-Eclampsia EV-encapsulated miR-101 from HUCMSCs also reduced blood pressure and 24 h urine protein in vivo, thereby ameliorating PE. +genetics_overexpression_suppress 32527205 hsa-mir-96 Uterine Cervical Neoplasms 5p was overexpressed in cervical cancer tissues, and microRNA +other 32527185 hsa-mir-127 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: hsa_circ_0001947/hsa-miR-637/RRM2 and hsa_circ_0072305/hsa-miR5p/DTL networks were constructed, and identified molecules may be involved in the occurrence and development of NSCLC. +other 32527185 hsa-mir-637 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: hsa_circ_0001947/hsa-miR-637/RRM2 and hsa_circ_0072305/hsa-miR5p/DTL networks were constructed, and identified molecules may be involved in the occurrence and development of NSCLC. +other 32527064 hsa-mir-17 Pulmonary Fibrosis 5p. +other 32527064 hsa-mir-16 Pulmonary Fibrosis 5p. +other 32527011 hsa-mir-10b Urinary Bladder Neoplasms Additionally, BC cases with low expression of miR5p and miR-106a-5p or high expression of miR-10b-5p showed shorter survival (adj-p = 0.0013, adj-p = 0.039 and adj-p = 0.047, respectively). +other 32527011 hsa-mir-106a Urinary Bladder Neoplasms Additionally, BC cases with low expression of miR5p and miR-106a-5p or high expression of miR-10b-5p showed shorter survival (adj-p = 0.0013, adj-p = 0.039 and adj-p = 0.047, respectively). +circulation_biomarker_diagnosis_down 32527011 hsa-mir-4508 Urinary Bladder Neoplasms miR-4508 resulted downregulated in plasma EVs of muscle-invasive BC patients, compared to controls (adj-p = 0.04). +other 32527011 hsa-mir-185 Urinary Bladder Neoplasms Additionally, BC cases with low expression of miR5p and miR-106a-5p or high expression of miR-10b-5p showed shorter survival (adj-p = 0.0013, adj-p = 0.039 and adj-p = 0.047, respectively). +lncRNA target 32526811 hsa-mir-99a Stomach Neoplasms Then we reveal that LINC00240 acts as an oncogene in GC progression via the miR-99a-5p/IGF1R axis. +other 32526477 hsa-mir-1238 Prostatic Neoplasms circFMN2 Sponges miR-1238 to Promote the Expression of LIM-Homeobox Gene 2 in Prostate Cancer Cells. +lncRNA target 32526476 hsa-mir-1205 Stomach Neoplasms In mechanism, we found that circCYFIP2 might serve as a competing endogenous RNA (ceRNA) of microRNA-1205 (miR-1205) in GC progression. Collectively, our findings suggested that circCYFIP2 might serve as an oncogenic circRNA to promote GC progression via the miR-1205/E2F1 axis, which provided a potential therapeutic target for the treatment of GC. +lncRNA target 32526457 hsa-mir-194 Carcinoma, Renal Cell In a summary, this study firstly uncovered that DARS-AS1 boosted DARS expression via absorbing miR +lncRNA target 32525819 hsa-mir-19a Osteochondritis Dissecans miR-19a mimics increased cell viability, decreased cell apoptosis of SK-N-SH cells following OGD/R, which effects was similar to PTEN siRNA; however, miR-19a inhibitor had the opposite roles with miR-19a mimics. +lncRNA target 32525527 hsa-mir-448 Lung Neoplasms MiR-448 targeting SATB1 to counteract the DDP resistance of lung cancer cells via Wnt/beta-catenin pathway. +exosome 32525285 hsa-mir-21 Lung Diseases AIM: To assess the exosomal miR-21/Let-7a ratio, a noninvasive method, in distinguishing non-small cell lung cancer (NSCLC) from benign pulmonary diseases. CONCLUSION: In the present study, our findings revealed that exosomal miR-21/Let-7a ratio holds considerable promise as a noninvasive biomarker for the diagnosis of NSCLC from benign pulmonary diseases. +exosome 32525285 hsa-let-7a Carcinoma, Non-Small-Cell Lung AIM: To assess the exosomal miR-21/Let-7a ratio, a noninvasive method, in distinguishing non-small cell lung cancer (NSCLC) from benign pulmonary diseases. CONCLUSION: In the present study, our findings revealed that exosomal miR-21/Let-7a ratio holds considerable promise as a noninvasive biomarker for the diagnosis of NSCLC from benign pulmonary diseases. +exosome 32525285 hsa-let-7a Lung Diseases AIM: To assess the exosomal miR-21/Let-7a ratio, a noninvasive method, in distinguishing non-small cell lung cancer (NSCLC) from benign pulmonary diseases. CONCLUSION: In the present study, our findings revealed that exosomal miR-21/Let-7a ratio holds considerable promise as a noninvasive biomarker for the diagnosis of NSCLC from benign pulmonary diseases. +exosome 32525285 hsa-mir-21 Carcinoma, Non-Small-Cell Lung AIM: To assess the exosomal miR-21/Let-7a ratio, a noninvasive method, in distinguishing non-small cell lung cancer (NSCLC) from benign pulmonary diseases. CONCLUSION: In the present study, our findings revealed that exosomal miR-21/Let-7a ratio holds considerable promise as a noninvasive biomarker for the diagnosis of NSCLC from benign pulmonary diseases. +transcription factor target 32525231 hsa-mir-25 Liver Neoplasms CONCLUSIONS: Transfer of miR3p by CHB-PNALT-Exo promoted the development of liver cancer by inhibiting the co-expression of TCF21 and HHIP. +transcription factor target 32525231 hsa-mir-25 Hepatitis CONCLUSIONS: Transfer of miR3p by CHB-PNALT-Exo promoted the development of liver cancer by inhibiting the co-expression of TCF21 and HHIP. +transcription factor target 32525231 hsa-mir-25 Hepatitis B, Chronic CONCLUSIONS: Transfer of miR3p by CHB-PNALT-Exo promoted the development of liver cancer by inhibiting the co-expression of TCF21 and HHIP. +target gene 32525225 hsa-mir-205 Psoriasis miR-205-5p inhibits psoriasis-associated proliferation and angiogenesis: Wnt/β-catenin and mitogen-activated protein kinase signaling pathway are involved. +genetics_overexpression_suppress 32525042 hsa-mir-544a Carcinoma, Endometrioid Quantitative real-time polymerase chain reaction (qRT-PCR) revealed miR-544a overexpression in EC tissue and cell lines, which was associated with a decreased in overall survival as revealed by Kaplan-Meier analysis. +lncRNA target 32525017 hsa-mir-148a Endometriosis LncRNA SNHG4 promotes the increased growth of endometrial tissue outside the uterine cavity via regulating c-Met mediated by miR-148a-3p, which may be used as diagnostic biomarker as well as molecular target in the treatment of endometriosis. +lncRNA target 32524841 hsa-mir-511 Colorectal Neoplasms Therefore, it was indicated that LINC02163 exerted pro-tumour effect through miR3p/AKT3 axis and was prognostic marker for colorectal cancer. +genetics_overexpression_promote 32524752 hsa-mir-377 Carcinoma, Non-Small-Cell Lung 5p could directly interact with NOVA2, and the overexpression of NOVA2 overturned miR +lncRNA target 32524576 hsa-mir-145 Esophageal Neoplasms In conclusion, silening FOXD2-AS1 significantly inhibited the proliferation and invasion of EC cells by regulating the miR5p/CDK6 axis. +lncRNA target 32524326 hsa-mir-16 Pancreatitis, Chronic In our study, we found that miR-15 and miR-16 decreased significantly in chronic pancreatitis and HDAC inhibition could recover the levels of these two miRNAs. And we proved that Bcl-2 and Smad5 were the target genes of miR-15 and miR-16, which illustrated how HDAC inhibition alleviated the apoptosis and fibrogenesis of PSCs in chronic pancreatitis. +lncRNA target 32524326 hsa-mir-15 Pancreatitis, Chronic In our study, we found that miR-15 and miR-16 decreased significantly in chronic pancreatitis and HDAC inhibition could recover the levels of these two miRNAs. And we proved that Bcl-2 and Smad5 were the target genes of miR-15 and miR-16, which illustrated how HDAC inhibition alleviated the apoptosis and fibrogenesis of PSCs in chronic pancreatitis. +genetics_knock down_suppress 32524321 hsa-mir-384 Cataract Overall, CircBPTF knockdown protected against HG-induced inflammatory injuries and oxidative stress by mediating the miR-384/LIN28B axis in HUVECs. +genetics_knock down_suppress 32524321 hsa-mir-384 Inflammation Overall, CircBPTF knockdown protected against HG-induced inflammatory injuries and oxidative stress by mediating the miR-384/LIN28B axis in HUVECs. +genetics_overexpression_suppress 32524269 hsa-mir-22 Ovarian Neoplasms RESULTS: miR-22 was low expressed and NLRP3 was overexpressed in ovarian cancer tissues and cells, and downregulation of miR-22 was associated with poor prognosis. +circulation_biomarker_diagnosis_up 32524116 hsa-mir-138 Squamous Cell Carcinoma of Head and Neck Luciferase reporter gene assay showed that the relative activity of PLD2 wild plasmid luciferase was significantly lower in oral cancer cells transfected with microRNA-138 than in other groups (P<0.05); The expression level of PLD2 gene in miR-138 group was significantly lower than that in blank control group and miR-NC group (P<0.05). +other 32523943 hsa-mir-212 Diabetic Neuropathies Furthermore, a global lncRNA-miRNA-mRNA ceRNA regulatory network in DPN model was constructed and miR5p and the significantly correlated lncRNAs with high degree were identified as key mediators in the pathophysiological processes of SCs in DPN. +other 32523864 hsa-mir-155 Breast Neoplasms This study correlated and quantified the expression of microRNA-155 with breast cancer to determine breast cancer progression. The obtained results demonstrate the selective determination of the microRNA-155 sequence and can help to diagnose breast cancer. +transcription factor target 32523663 hsa-mir-7977 Kidney Diseases A high level of insulin can activate mir-7977/SIRT3 signaling, resulting in tubular injury by inducing oxidative stress as well as reabsorption dysfunction by inhibiting the expression of cubilin, ultimately contributing to IGT-RI. +transcription factor target 32523663 hsa-mir-7977 Reperfusion Injury, Renal Ischemia A high level of insulin can activate mir-7977/SIRT3 signaling, resulting in tubular injury by inducing oxidative stress as well as reabsorption dysfunction by inhibiting the expression of cubilin, ultimately contributing to IGT-RI. +genetics_overexpression_promote 32523379 hsa-mir-665 Stomach Neoplasms Rescue assays revealed that overexpression of CRIM1 attenuated the inhibitory effects of miR-665 in GC progression and EMT. +genetics_overexpression_promote 32523376 hsa-mir-1296 Carcinoma, Hepatocellular 5p on HCC cell progression was rescued by TXNDC5 overexpression. +lncRNA target 32523373 hsa-mir-708 Osteosarcoma CONCLUSION: Our findings revealed SP1-induced upregulation of LINC00514 as an oncogene in OS through competitively binding to miR-708, suggesting that there are potential diagnostic and treatment values of LINC00514 in OS. +genetics_knock down_promote 32523358 hsa-mir-374b Carcinoma, Non-Small-Cell Lung In NSCLC cells, the overexpression of miR-374b-5p could inhibit NSCLC cell proliferation, migration and invasion and could directly target FOXP1. +target gene 32523352 hsa-mir-377 Uterine Cervical Neoplasms Interfering Human Papillomavirus E6/E7 Oncogenes in Cervical Cancer Cells Inhibits the Angiogenesis of Vascular Endothelial Cells via Increasing miR-377 in Cervical Cancer Cell-Derived Microvesicles. +circulation_biomarker_diagnosis_up 32523124 hsa-mir-1260b congenital fibrosarcoma In addition, high miR-1260b expression in serum was correlated with radiological tail-like patterns, characteristic of the infiltrative MFS. +lncRNA target 32522628 hsa-mir-29 Neuroblastoma MiR-29 could bind to NOL4L, and the influence of NOL4L intervention on the functions of NB cells could be alleviated by the transfection of miR-29 inhibitor. +circRNA target 32522568 hsa-mir-26a Osteoarthritis KEY FINDINGS: CircRNA-9119 and phosphatase and tensin homolog (PTEN) expression decreased in OA-affected cartilage and interleukin (IL)-1beta-induced chondrocytes, and miR-26a expression significantly decreased in normal cells and tissues. SIGNIFICANCE: CircRNA-9119 is an important regulator of IL-1beta-treated chondrocytes through the miR-26a/PTEN axis, possibly contributing to OA development. +transcription factor target 32522441 hsa-mir-218 Prostatic Neoplasms We previously found that miR-218 inhibits tumor angiogenesis through the RICTOR/VEGFA axis in prostate cancer (PCa). +lncRNA target 32522234 hsa-mir-424 Urinary Bladder Neoplasms CONCLUSIONS: Collectively, our current results strongly suggest that miR-424 tightly participates in the acquisition/maintenance of CDDP-resistant phenotype of bladder cancer cells through down-regulation of its targets UNC5B and SIRT4, and thus combination chemotherapy of CDDP plus HIF-1alpha/miR-424 inhibition might have a significant impact on hypoxic as well as normoxic bladder cancer cells. +lncRNA target 32522221 hsa-mir-194 Acute Lung Injury In LPS-induced ALI, NF-kappaB mediates the CXCR4 expression by inhibiting the expression of miR-194, thus promoting the inflammatory injury of lung. +circulation_biomarker_diagnosis_ns 32522208 hsa-mir-92a Cerebrovascular Disorders CONCLUSION: The data from this study indicated that circulating increased miR-92a may serve as a noninvasive diagnostic biomarker for ACAS and a potential risk factor for the future onset of cerebrovascular events. +circulation_biomarker_diagnosis_ns 32522208 hsa-mir-92a Carotid Stenosis CONCLUSION: The data from this study indicated that circulating increased miR-92a may serve as a noninvasive diagnostic biomarker for ACAS and a potential risk factor for the future onset of cerebrovascular events. +other 32522016 hsa-mir-127 Ovarian Neoplasms Conclusion: The authors' findings indicated that Met expedited paclitaxel sensitivity by regulating SNHG7/miR5p-mediated autophagy in ovarian cancer cells. +genetics_knock down_suppress 32522014 hsa-mir-223 Breast Neoplasms Conclusion: CircABCB10 knockdown contributed to irradiation sensitivity by negatively regulating glycolysis via the miR3p/PFN axis in breast cancer. +other 32522013 hsa-mir-623 Carcinoma, Hepatocellular Therefore, CTBP1-AS2 promotes cell proliferation in HCC by regulating the miR-623/cyclin D1 axis. +genetics_knock down_promote 32521912 hsa-mir-204 Nasopharyngeal Carcinoma Conversely to miR-204 effect, knockdown of CXCR4 showed an inhibitory effect on NPC cell progression. +genetics_overexpression_suppress 32521911 hsa-mir-9 Glioma Overexpression of miR-9 also induced arrest of U87 glioma cells at G2/M checkpoint of cell cycle. +lncRNA target 32521902 hsa-mir-17 Osteosarcoma Suppression of miR-17 resulted in decrease of the viability and colony formation of the SAOS-2 osteosarcoma cells. +genetics_overexpression_promote 32521898 hsa-mir-24 Stomach Neoplasms Wound healing and transwell assay revealed that miR-24 overexpression also inhibited the migration and invasion and also enhanced the chemosensitivity of the SNU1 gastric cancer cells. +lncRNA target 32521894 hsa-mir-107 Liver Neoplasms Moreover, MINCR was capable of promoting the proliferation and inhibiting apoptosis of liver cancer cells via regulating microRNA-107/beta-catenin. +other 32521885 hsa-mir-21 Colonic Neoplasms MALAT1 can regulate miR-21 to regulate the migration and invasion of colon cancer cells. +genetics_overexpression_promote 32521879 hsa-mir-16 Lung Neoplasms Overexpression of miR-16 inhibited the growth and metastasis of the DMS-53 lung cancer cells via induction of the apoptotic cell death. +lncRNA target 32521875 hsa-mir-138 Lung Neoplasms PURPOSE: The current study was set with a purpose to assess the regulatory role of micro RNA (miR)-138 in human lung cancer cells with emphasis on the underlying mechanism of action. miR-138 also inhibited the metastasis of lung cancer cells. +circulation_biomarker_prognosis_up 32521873 hsa-mir-548v Adenocarcinoma of Lung The expression and clinic value of serum miR-548v in 50 patients with LUAD (study group) and 50 healthy individuals (control group) was detected by the quantitative real time polymerase chain reaction (qRT-PCR), and the diagnostic value of miR-548v in LUAD was analyzed by the receiver operating characteristic (ROC) curve. +genetics_knock down_promote 32521870 hsa-mir-492 Ovarian Neoplasms MiR-492 regulated the expression of SOX7 via directly binding to the 3'-untranslated region (3'-UTR) of SOX7 mRNA in SKOV3 OC cells. +genetics_knock down_suppress 32521851 hsa-mir-335 Breast Neoplasms The overexpression of MAP3K2 reversed the growth inhibition in miR-335 mimics-transfected BC cells. +other 32521662 hsa-mir-34b Oligospermia MiR-34b-5p levels in the control group were significantly higher compared to the asthenozoospermia group (p < 0.05) and compared to the oligozoospermia group (p < 0.001). +other 32521662 hsa-mir-34b Asthenozoospermia MiR-34b-5p levels in the control group were significantly higher compared to the asthenozoospermia group (p < 0.05) and compared to the oligozoospermia group (p < 0.001). +other 32521543 hsa-mir-2861 Osteoporosis, Postmenopausal CONCLUSIONS TPTD treatment potentially affects the expression of the pro-osteoclastogenic miR-21a-5p and miRs related to the expression of osteoblastic genes RUNX2 (miR23a-3p), COL1 (miR-29a-3p), and HDAC5 (miR-2861), while sequential treatment with Dmab acts in the opposite direction. +other 32521540 hsa-mir-23a Inflammation 5p were significantly upregulated within 6h of a hypoxia insult. +other 32521540 hsa-mir-23 Encephalitis 5p were significantly upregulated within 6h of a hypoxia insult. +other 32521540 hsa-mir-23 Inflammation 5p were significantly upregulated within 6h of a hypoxia insult. +other 32521540 hsa-mir-23a Encephalitis 5p were significantly upregulated within 6h of a hypoxia insult. +genetics_knock down_suppress 32521454 hsa-mir-149 Osteoarthritis In a word, knockdown of XIST can repress the development of OA by miR +other 32521298 hsa-mir-20b Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: The miR-20b-5p expression status is a promising molecular tissue biomarker in LSCC, with an independent prognostic value, and thus merits further validation in larger cohorts of patients. +genetics_overexpression_promote 32520926 hsa-mir-143 Periodontitis CONCLUSIONS MEG3 overexpression inhibited LPS-induced injury in PDLCs by inactivating the AKT/IKK pathway via sponging miR +lncRNA target 32520206 hsa-mir-424 Nasopharyngeal Carcinoma 5p inhibited the proliferation, migration, and invasion of NPC cells by decreasing AKT3 expression. +circulation_biomarker_diagnosis_ns 32520192 hsa-mir-155 Tuberculosis OBJECTIVES: To analyze the differential expression of miR-21, miR-29a, miR-99b and miR-155 in serum samples from patients with latent tuberculosis (TB) and active TB compared to healthy controls. +other 32520081 hsa-mir-21 Alcoholism PURPOSE: To evaluate the effect of chronic alcoholism on morphometry and apoptosis mechanism and correlate with miRNA-21 expression in the corpus cavernosum of rats. +other 32519740 hsa-mir-509 Prostatic Neoplasms 3p-PBX3 axis in regulating the progress of PCa. +circulation_biomarker_diagnosis_ns 32518782 hsa-mir-19a Diabetes Mellitus, Type 2 METHODS: MiR-148b, miR-223, miR-130a, and miR-19a levels were detected by real-time polymerase chain reaction in serum of healthy controls, individuals with impaired glucose regulation, and T2DM patients. CONCLUSION: In summary, we have built a multi-parameter diagnostic model consisting of miR-148b, miR-223, miR-130a, and miR-19a for the detection of T2DM. +circulation_biomarker_diagnosis_ns 32518782 hsa-mir-148b Diabetes Mellitus, Type 2 METHODS: MiR-148b, miR-223, miR-130a, and miR-19a levels were detected by real-time polymerase chain reaction in serum of healthy controls, individuals with impaired glucose regulation, and T2DM patients. CONCLUSION: In summary, we have built a multi-parameter diagnostic model consisting of miR-148b, miR-223, miR-130a, and miR-19a for the detection of T2DM. +circulation_biomarker_diagnosis_ns 32518782 hsa-mir-130a Diabetes Mellitus, Type 2 METHODS: MiR-148b, miR-223, miR-130a, and miR-19a levels were detected by real-time polymerase chain reaction in serum of healthy controls, individuals with impaired glucose regulation, and T2DM patients. CONCLUSION: In summary, we have built a multi-parameter diagnostic model consisting of miR-148b, miR-223, miR-130a, and miR-19a for the detection of T2DM. +genetics_overexpression_promote 32518525 hsa-mir-124 Carcinoma, Hepatocellular CONCLUSION: We demonstrate for the first time that ZKSCAN3 is overexpressed in HCC tissues and promotes migration, invasion and EMT process through ITGB4-dependent FAK/AKT activation, which was regulated by miR-124, suggesting the potential therapeutic value for HCC. +lncRNA target 32518524 hsa-mir-496 Prostatic Neoplasms CONCLUSIONS: To sum up, LINC00689 promotes PCa progression via regulating miR-496/CTNNB1 to activate Wnt pathway, which may contribute to research about new targets for PCa treatment. +lncRNA target 32518523 hsa-mir-381 Breast Neoplasms CONCLUSION: FLVCR1-AS1 regulates BC malignant behavior via sequestering miR +lncRNA target 32517436 hsa-mir-653 Osteoarthritis In conclusion, down-regulated XIST was involved in the injury of chondrocytes during the pathophysiological process of OA, and XIST up-regulation protected chondrocytes from inflammatory injury via regulating miR +genetics_overexpression_promote 32516127 hsa-mir-223 Stomach Neoplasms LncRNA ADAMTS9-AS2 overexpression enhanced the cytotoxic effects of cisplatin on CR-GC cells, which were reversed by overexpressing miR +genetics_knock down_promote 32515533 hsa-mir-361 Uterine Cervical Neoplasms More importantly, rescue assays delineated that knockdown of HuR after overexpressing miR +lncRNA target 32515520 hsa-mir-153 Osteosarcoma In conclusion, this work demonstrates that lncRNA-XIST promotes the oxidative stress-induced OS cell invasion, migration, and EMT through the miR-153/SNAI1 pathway, presenting lncRNA-XIST as a promising therapeutic target for treating metastatic OS. +genetics_overexpression_promote 32515360 hsa-mir-17 Endometriosis 5p was remarkably down-regulated in endometriosis tissues, serums and cells, and overexpression of miR +transcription factor target 32515177 hsa-mir-224 Dehydration In this experiment, we explored whether naringenin can increase the expression of superoxide dismutase 1(SOD1), reduce the oxidative stress of PC12 cells induced by homocysteine (Hcy), and decrease the apoptosis of PC12 cells induced by Hcy by inhibiting the expression of mir3p. +lncRNA target 32515146 hsa-mir-1271 Adenocarcinoma of Lung 5p functioned as a tumor suppressor in LAD, and lncRNA ZFAS1 promoted LAD development by downregulating miR +genetics_overexpression_promote 32514270 hsa-mir-22 Carcinoma, Non-Small-Cell Lung FOXM1 was a target of miR-22, and overexpression of miR-22 inhibited cell carcinogenesis in LUSC by targeting FOXM1. +lncRNA target 32514244 hsa-mir-663a Triple Negative Breast Neoplasms Rescue experiment proved that miR-663a suppression or CMIP (c-Maf inducing protein) enhancement could countervail LINC01123 depletion-mediated effects on TNBC cellular processes. +other 32514154 hsa-mir-19a Autistic Disorder 3p, and miR-499a-5p) were expressed at low to very low levels compared to those in healthy controls. +other 32514154 hsa-mir-126 Autistic Disorder 3p, and miR-499a-5p) were expressed at low to very low levels compared to those in healthy controls. +other 32514154 hsa-mir-361 Autistic Disorder 3p, and miR-499a-5p) were expressed at low to very low levels compared to those in healthy controls. +other 32514154 hsa-mir-150 Autistic Disorder 3p, and miR-499a-5p) were expressed at low to very low levels compared to those in healthy controls. +other 32514154 hsa-mir-499a Autistic Disorder 3p, and miR-499a-5p) were expressed at low to very low levels compared to those in healthy controls. +other 32514154 hsa-mir-613 Autistic Disorder 3p, and miR-499a-5p) were expressed at low to very low levels compared to those in healthy controls. +transcription factor target 32514152 hsa-mir-92b Gallbladder Neoplasms Our findings revealed that DCA might function as a tumor suppressive factor in GBC at least by interfering with miR-92b-3p maturation, and suggested that DCA treatment could provide a new therapeutic strategy for GBC. +lncRNA target 32514126 hsa-mir-185 Fibrosis, Renal 5p reduced the expression of ER stress-related proteins and inhibited epithelial dedifferentiation via downregulation of ATF6, thereby improving UUO-induced renal fibrosis. +lncRNA target 32513983 hsa-mir-488 Carcinoma, Non-Small-Cell Lung Collectively, present research reveals the crucial function of circSLC25A16 on NSCLC glycolysis through miR3p/HIF-1alpha/LDHA, suggesting the underlying pathogenesis for NSCLC and providing a therapeutic strategy for precise treatment. +transcription factor target 32513543 hsa-mir-16 Inflammation MiR-16 has been suggested to be closely associated with cell proliferation and inflammation. Furthermore, miR-16 impeded cell proliferation and inflammation via targeting CRP in VMSCs. +other 32513543 hsa-mir-16 Colonic Neoplasms The regulatory role of the RNA binding protein HuR on miR-16 has been reported in colon cancer. +lncRNA target 32513531 hsa-mir-505 Pancreatic Carcinoma These results confirmed that ZEB1-AS1 promoted the tumorigenesis of PC through the miR-505/TRIB2 axis, which indicated that ZEB1-AS1 might function as a biomarker for PC treatment and provide a new therapeutic direction in PC. +circulation_biomarker_diagnosis_ns 32513357 hsa-mir-124 Cerebral Infarction, Acute Receiver operating characteristic (ROC) curve was used to evaluate efficacy of serum miR-124, TNF-alpha and IL-1beta used alone or in combination to diagnose carotid vulnerable plaques in ACI. +other 32513194 hsa-mir-29b Liver Cirrhosis All these results indicate GMO- and miR-29b-loaded cRGD-modified NPs have the potential for clinical use to treat liver fibrosis. +lncRNA target 32513149 hsa-mir-299 lung squamous cell carcinoma CONCLUSION: MIR205HG acts as a competing endogenous RNA (ceRNA) to expedite cell proliferation and progression via targeting miR3p in LUSC. +other 32513089 hsa-mir-547 Neuralgia The intravenous application of bone marrow stromal cells (BMSCs) reduced the depression of miR5p in both the DRG and SDH, and pain hypersensitivity produced by the CCI or antagomir-miR547-5p application. +genetics_overexpression_promote 32512976 hsa-mir-196b Ovarian Neoplasms Overexpression of microRNA-196b remarkably enhanced the proliferation, invasiveness and migratory ability of OCa cells. +genetics_overexpression_promote 32512881 hsa-mir-144 Uveal melanoma Overexpression of miR122 and miR144 led to reduced expression of ADAM10 and c-Met in the UM cell lines and impaired cell proliferation, migration, cell cycle and shedding of c-Met ecto-domain. +genetics_overexpression_promote 32512881 hsa-mir-122 Uveal melanoma Overexpression of miR122 and miR144 led to reduced expression of ADAM10 and c-Met in the UM cell lines and impaired cell proliferation, migration, cell cycle and shedding of c-Met ecto-domain. +other 32512858 hsa-mir-26b Burkitt Lymphoma The miR-26b-5p/KPNA2 Axis Is an Important Regulator of Burkitt Lymphoma Cell Growth. +genetics_overexpression_promote 32512576 hsa-mir-25 Urinary Bladder Neoplasms Further experiments showed that the effects of increased cell proliferation, invasion, migration, and EMT promoted by MT3 overexpression were abolished by miR +circulation_biomarker_diagnosis_up 32512528 hsa-mir-384 Pneumonia, Mycoplasma Previously, we found that miR-384 is upregulated in the placenta and plasma in the context of PE. +other 32512528 hsa-mir-384 Trophoblastic Neoplasms In this study, we elucidated the function of miR-384 in the trophoblast cell line HTR-8/SVneo and the trophoblastic tumor cell line JEG-3. +lncRNA target 32512343 hsa-mir-543 Breast Neoplasms Abnormal expression of miR-543 is associated with tumorigenesis and progression of various human cancers; however, the knowledge about the role of miR-543 in breast cancer metastasis is still unknown. In this study, we demonstrated that miR-543 inhibits the EMT-like phenotype and TGF-beta-induced breast cancer metastasis both in vitro and in vivo by targeting ZNF281. +other 32512270 hsa-mir-665 Ischemic Stroke However, whether miR3p participates in regulating microglial inflammation during ischemic stroke is underdetermined. +other 32512270 hsa-mir-665 Stroke 3p in stroke-induced inflammation in microglial cells using a cellular model of oxygen-glucose deprivation (OGD)-stimulated microglial cells in vitro. +lncRNA target 32512188 hsa-mir-29b Stomach Neoplasms Additionally, our data suggested LINC00511 could decrease the expression of miR-29b, followed by inducing GC development. All the data showed that the LINC00511/miR-29b/KDM2A axis can be used as a diagnostic and therapeutic target for GC. +genetics_knock down_promote 32511950 hsa-mir-525 Ovarian Neoplasms Knockdown of miR +circRNA target 32511866 hsa-mir-326 Lung Neoplasms In conclusion, circ_POLA2 promotes lung cancer cell stemness and progression via regulating the miR-326/GNB1 axis, which might serve as a novel therapeutic target for lung cancer patients. +lncRNA target 32510855 hsa-mir-182 Intestinal Diseases Together, our research implicated up-regulation of miR-182 inhibited autophagy to alleviate intestinal I/R injury via mTOR by targeting Deptor. +lncRNA target 32510626 hsa-mir-181b Necrobiotic Disorders Besides, the silencing of STAT-3 reduced anti-miR-181b-5p-mediated HUVEC pyroptosis via regulating NLRP3 inflammasome activation. +other 32510626 hsa-mir-181b Angelman Syndrome Given the role of mechanosensitive miR-181b-5p and STAT-3 in the shear stress-induced pyroptosis, regulation of their expression levels may be a promising strategy to control AS. +other 32509771 hsa-mir-6768 FG syndrome 5p were identified in the FGR tissues. +other 32509578 hsa-mir-142 Breast Neoplasms 3p, hsa-miR-125a-5p, and hsa-let-7c-5p) was subsequently validated in a second cohort of 32 breast and 32 matched LNM tumor tissues. +other 32509578 hsa-mir-150 Breast Neoplasms 3p, hsa-miR-125a-5p, and hsa-let-7c-5p) was subsequently validated in a second cohort of 32 breast and 32 matched LNM tumor tissues. +other 32509578 hsa-mir-146a Breast Neoplasms 3p, hsa-miR-125a-5p, and hsa-let-7c-5p) was subsequently validated in a second cohort of 32 breast and 32 matched LNM tumor tissues. +other 32509578 hsa-mir-127 Breast Neoplasms 3p, hsa-miR-125a-5p, and hsa-let-7c-5p) was subsequently validated in a second cohort of 32 breast and 32 matched LNM tumor tissues. +other 32509578 hsa-mir-200c Breast Neoplasms 3p, hsa-miR-125a-5p, and hsa-let-7c-5p) was subsequently validated in a second cohort of 32 breast and 32 matched LNM tumor tissues. +other 32509578 hsa-mir-125a Breast Neoplasms 3p, hsa-miR-125a-5p, and hsa-let-7c-5p) was subsequently validated in a second cohort of 32 breast and 32 matched LNM tumor tissues. +other 32509578 hsa-mir-141 Breast Neoplasms 3p, hsa-miR-125a-5p, and hsa-let-7c-5p) was subsequently validated in a second cohort of 32 breast and 32 matched LNM tumor tissues. +other 32509578 hsa-mir-210 Breast Neoplasms 3p, hsa-miR-125a-5p, and hsa-let-7c-5p) was subsequently validated in a second cohort of 32 breast and 32 matched LNM tumor tissues. +other 32509578 hsa-mir-205 Breast Neoplasms 3p, hsa-miR-125a-5p, and hsa-let-7c-5p) was subsequently validated in a second cohort of 32 breast and 32 matched LNM tumor tissues. +other 32509578 hsa-mir-200b Breast Neoplasms 3p, hsa-miR-125a-5p, and hsa-let-7c-5p) was subsequently validated in a second cohort of 32 breast and 32 matched LNM tumor tissues. +other 32509578 hsa-let-7c Breast Neoplasms 3p, hsa-miR-125a-5p, and hsa-let-7c-5p) was subsequently validated in a second cohort of 32 breast and 32 matched LNM tumor tissues. +other 32509578 hsa-mir-214 Breast Neoplasms 3p, hsa-miR-125a-5p, and hsa-let-7c-5p) was subsequently validated in a second cohort of 32 breast and 32 matched LNM tumor tissues. +other 32509578 hsa-mir-155 Breast Neoplasms 3p, hsa-miR-125a-5p, and hsa-let-7c-5p) was subsequently validated in a second cohort of 32 breast and 32 matched LNM tumor tissues. +other 32509578 hsa-mir-200a Breast Neoplasms 3p, hsa-miR-125a-5p, and hsa-let-7c-5p) was subsequently validated in a second cohort of 32 breast and 32 matched LNM tumor tissues. +other 32509385 hsa-mir-130a Carcinoma, Hepatocellular In this study, we found that COX7RP is frequently over-expressed in HCC mainly due to the down-regulation of miR-130a-3p and predicts poor prognosis of HCC patients. +lncRNA target 32509217 hsa-mir-144 Carcinoma, Hepatocellular Collectively, we showed NORAD serves as an oncogenic lncRNA to promote HCC progression via the miR +lncRNA target 32509216 hsa-mir-150 Pancreatic Carcinoma In the present study, we found that LINC00152 was significantly up-regulated while miR-150 was down-regulated both in tissues and cell lines of PC, indicating their negative correlation in PC progression. Altogether, our findings concluded that LINC00152 facilitated PC progression through inhibiting miR-150 expression, indicating an innovative therapeutic target for PC. +lncRNA target 32509211 hsa-mir-23c Carcinoma, Hepatocellular miR-23c was downregulated, while HMGB2 was upregulated in HCC tissues and cells. We revealed SNHG5 could exert an oncogenic role in HCC via regulating miR-23c/HMGB2 axis. +genetics_knock down_promote 32509208 hsa-mir-497 Osteosarcoma Rescue experiments confirmed that miR-497 inhibition could partially reverse the inhibitory effect of AFAP1-AS1 knockdown on OS cells. Taken together, these findings indicate that AFAP1-AS1 promotes OS progression by regulating miR-497/IGF1R axis, providing a therapeutic target for OS. +circulation_biomarker_diagnosis_up 32509207 hsa-mir-135b Femur Head Necrosis The results of qRT-PCR for the first time confirmed that the expression of hsa-miR-135b-5p was strikingly up-regulated in SLE-SONFH group which were consistent with miRNA sequencing results. In conclusion, this study provides a novel and fundamental serum exosomal miRNAs profile of SONFH and hsa-miR-135b-5p may be identified as a unique diagnostic biomarker for SONFH. +other 32509198 hsa-mir-142 Prostatic Neoplasms 5p), which improves PCa specificity of the PSA test, for, firstly, predicting the presence of malignant tumors in a sample from the total population and secondly, and more interestingly for clinicians, for predicting PCa in samples from the positive PSA screening test (PSA>4 ng/ml). +other 32509198 hsa-mir-223 Prostatic Neoplasms 5p), which improves PCa specificity of the PSA test, for, firstly, predicting the presence of malignant tumors in a sample from the total population and secondly, and more interestingly for clinicians, for predicting PCa in samples from the positive PSA screening test (PSA>4 ng/ml). +other 32509198 hsa-mir-93 Prostatic Neoplasms 5p), which improves PCa specificity of the PSA test, for, firstly, predicting the presence of malignant tumors in a sample from the total population and secondly, and more interestingly for clinicians, for predicting PCa in samples from the positive PSA screening test (PSA>4 ng/ml). +other 32509188 hsa-mir-196a-2 Abortion, Habitual Our study found that rs11614913 T/T in pri-miR-196a-2 was associated with the increase risk of human unexplained RSA (URSA) in recessive mode in Chinese Han population. +genetics_knock down_suppress 32509100 hsa-mir-361 Wounds and Injuries In conclusion, our results indicate that knockdown of MALAT1 inhibits HG-induced vascular endothelial injury through regulating miR3p/SOCS3 axis, suggesting that inhibition of MALAT1 as a potential target for endothelial injury therapy for DM. +genetics_knock down_suppress 32509100 hsa-mir-361 Diabetes Mellitus In conclusion, our results indicate that knockdown of MALAT1 inhibits HG-induced vascular endothelial injury through regulating miR3p/SOCS3 axis, suggesting that inhibition of MALAT1 as a potential target for endothelial injury therapy for DM. +target gene 32509059 hsa-mir-149 colon carcinoma miR-149 regulates the proliferation and apoptosis of human colonic carcinoma cells by targeting FZD5. +genetics_overexpression_promote 32509057 hsa-mir-205 Ovarian Neoplasms The overexpression of lncRNA MEG3 inhibits cell viability and invasion and promotes apoptosis in ovarian cancer by sponging miR-205-5p. +other 32508878 hsa-mir-29c Colorectal Adenocarcinoma One key DEM, hsa-miR-29c, which was identified when we compared the differentially expressed molecules found in the comparison CRA versus normal samples to the ones obtained in the comparison CRC versus CRA, was also identified in CRC samples compared to CRA ones. +exosome 32508877 hsa-mir-34c Thyroid Nodule Further validation indicated that the levels of exosomal miR +exosome 32508877 hsa-mir-146b Thyroid Nodule Further validation indicated that the levels of exosomal miR +exosome 32508877 hsa-mir-182 Thyroid Nodule Further validation indicated that the levels of exosomal miR +target gene 32508871 hsa-mir-135a Colorectal Neoplasms Dysregulation of CircRNA_0001946 Contributes to the Proliferation and Metastasis of Colorectal Cancer Cells by Targeting MicroRNA-135a-5p. +lncRNA target 32508529 hsa-mir-19b Stomach Neoplasms Functional assay demonstrated that miR-19b-3p inhibited GC cell growth, migration and invasion via negatively regulating NRP1. +lncRNA target 32508527 hsa-mir-199a Sepsis These revealed miR-199a-5p exacerbated the intestinal barrier dysfunction via inhibiting SP-D and activating the NF-kappaB pathway in sepsis. +genetics_knock down_promote 32508344 hsa-mir-595 Carcinoma, Non-Small-Cell Lung Silencing of miR-595 or overexpression of E2F2 could partially reversed the inhibitory role of circ_0109320 knockdown in NSCLC cells. +genetics_overexpression_promote 32508321 hsa-mir-143 Osteosarcoma Restoration of the HK2 expression in the lncRNA-SARCC-overexpressing osteosarcoma cells reversed cisplatin resistance, suggesting that lncRNA-SARCC-mediated cisplatin sensitivity may be via glycolysis in the miR +other 32508320 hsa-mir-1303 Carcinoma, Non-Small-Cell Lung CONCLUSION: These results suggest that miR-1303 may be a potential prognostic biomarker for NSCLC and be involved in the progression of NSCLC. +lncRNA target 32508267 hsa-mir-12129 Stomach Neoplasms Our results collectively suggested that microRNA-12129 suppressed cell proliferation and cell cycle progression in gastric cancer by targeting sirtuin 1. +other 32508177 hsa-mir-21 Liver Cirrhosis Previous studies have described the involvement of ACAT1 in fibrogenesis; thus, regulation of the Acat1 gene by miR-21 may play a role in DDT exposure-mediated liver fibrosis. +other 32508020 hsa-mir-148a Breast Neoplasms ATPase copper transporter A, negatively regulated by miR-148a-3p, contributes to cisplatin resistance in breast cancer cells. +other 32508012 hsa-mir-182 Multiple Sclerosis 5p expression correlated with measures of cognitive disability in multiple sclerosis. +other 32508012 hsa-mir-96 Multiple Sclerosis 5p expression correlated with measures of cognitive disability in multiple sclerosis. +other 32508012 hsa-mir-183 Multiple Sclerosis CONCLUSIONS: Erythrocyte miR-183 cluster members may be developed into specific multiple sclerosis biomarkers that could assist with diagnosis and disability monitoring. +genetics_knock down_promote 32507977 hsa-mir-140 Hirschsprung Disease 5p was significantly downregulated in HSCR tissue samples with increased expression of EGR2, and knockdown of miR +other 32507766 hsa-mir-139 Colorectal Neoplasms 5p/NOTCH1 axis functions as a key regulator in CRC metastasis. +lncRNA target 32507765 hsa-mir-34 Cystic Fibrosis 5p inhibited cell viability and proliferation of cardiac fibroblasts (CF). +other 32507001 hsa-mir-21 Cranial Nerve Injuries The aim of this study was to explore the molecular mechanism of miR-21 promoting Schwann cells (SC) proliferation and axon regeneration after peripheral nerve injury, providing a theoretical basis for injured nerve repair. Nerve injury models were constructed to determine the expression of miR-21 in the injured nerve by Quantitative Real-Time PCR (qRT-PCR). +other 32506974 hsa-mir-148b Pheochromocytoma OBJECTIVES: To investigate effects of circular RNA (circRNA) 001372 and its antagonist miRNAs-148b-3p on propofol-induced neurotoxicity and neuroinflammation in rat brain and pheochromocytoma cells. +other 32506974 hsa-mir-148b Neurotoxicity Syndromes OBJECTIVES: To investigate effects of circular RNA (circRNA) 001372 and its antagonist miRNAs-148b-3p on propofol-induced neurotoxicity and neuroinflammation in rat brain and pheochromocytoma cells. +other 32506974 hsa-mir-148b Neurogenic Inflammation OBJECTIVES: To investigate effects of circular RNA (circRNA) 001372 and its antagonist miRNAs-148b-3p on propofol-induced neurotoxicity and neuroinflammation in rat brain and pheochromocytoma cells. +other 32506887 hsa-mir-489 Carcinoma, Non-Small-Cell Lung The results of RT-qPCR showed that hsa-miR-181a, hsa-miR-199b, hsa-miR-489 and hsa-miR-589 were significantly up-regulated in the lung cancer tissues of radiotherapy-resistant NSCLC patients compared with those in non-radiotherapy-resistant NSCLC patients. +other 32506887 hsa-mir-199b Carcinoma, Non-Small-Cell Lung The results of RT-qPCR showed that hsa-miR-181a, hsa-miR-199b, hsa-miR-489 and hsa-miR-589 were significantly up-regulated in the lung cancer tissues of radiotherapy-resistant NSCLC patients compared with those in non-radiotherapy-resistant NSCLC patients. +lncRNA target 32506887 hsa-mir-181a Carcinoma, Non-Small-Cell Lung CONCLUSIONS: MiR-181a reduces the radiosensitivity of NSCLC via inhibiting PTEN expression. +transcription factor target 32506869 hsa-mir-155 Pulmonary Fibrosis CONCLUSION: In vivo treatment with antagomiR-155 alleviated the pathological changes induced by BLM and may be a promising therapeutic strategy for pulmonary fibrosis. +lncRNA target 32506598 hsa-mir-24 Carcinoma, Hepatocellular In particular, a novel DE-lncRNA, RP11-85G21.1 (lnc85), promoted HCC cellular proliferation and migration by targeted binding and regulating of miR5p. +lncRNA target 32506440 hsa-mir-7116 Pleural Effusion, Malignant 5p suppressed IL +exosome 32506013 hsa-mir-20a Ovarian Insufficiency, Premature The downstream protein expression (ANT2, AMP-dependent kinase [AMPK], and L-OPA1) was downregulated in the hGCs-SIRT4KD group but disappeared in the Exosanti-miR-320a/POI group. +lncRNA target 32505917 hsa-mir-29c Lung Neoplasms 3p were involved in the in vivo pathogenesis of NNK-induced lung cancer, and lico A could reverse the effect of NNK both in vivo and in vitro to elicit lung cancer chemopreventive effects through, at least partially, these five ectopically expressed miRNAs, especially miR +lncRNA target 32505917 hsa-mir-20a Lung Neoplasms 3p were involved in the in vivo pathogenesis of NNK-induced lung cancer, and lico A could reverse the effect of NNK both in vivo and in vitro to elicit lung cancer chemopreventive effects through, at least partially, these five ectopically expressed miRNAs, especially miR +lncRNA target 32505917 hsa-mir-28 Lung Neoplasms 3p were involved in the in vivo pathogenesis of NNK-induced lung cancer, and lico A could reverse the effect of NNK both in vivo and in vitro to elicit lung cancer chemopreventive effects through, at least partially, these five ectopically expressed miRNAs, especially miR +lncRNA target 32505917 hsa-let-7d Lung Neoplasms 3p were involved in the in vivo pathogenesis of NNK-induced lung cancer, and lico A could reverse the effect of NNK both in vivo and in vitro to elicit lung cancer chemopreventive effects through, at least partially, these five ectopically expressed miRNAs, especially miR +genetics_overexpression_promote 32505823 hsa-mir-182 Thyroid Cancer, Papillary (f) Overexpression of miR +genetics_overexpression_promote 32505707 hsa-mir-612 Cholangiocarcinoma Overexpression of miR-612 could rescue the proliferation, migration and invasion of cholangiocarcinoma cells caused by lncRNA H19 overexpression. +other 32505695 hsa-mir-132 Ovarian Diseases Altogether, these findings contribute to understanding the hormonal disbalance caused by DOX in human ovarian cells and suggest miR-132 as a putative sensor to predict DOX-induced ovarian toxicity. +circulation_biomarker_diagnosis_up 32505219 hsa-mir-33a Diabetes, Gestational RESULTS: miR-33a-5p was upregulated in the blood samples from GDM, and was positively correlated with blood glucose (p < 0.0001). +transcription factor target 32505188 hsa-mir-142 Nervous System Diseases 5p downregulation plays a neuroprotective role in protecting against isoflurane-induced neurological impairment through regulating neuron cell viability and apoptosis. +lncRNA target 32504995 hsa-mir-150 uric acid nephrolithiasis In summary, our studies demonstrate that rhein has a protective effect against UAN by inhibiting renal inflammatory injury via lincRNA-Cox2/miR5p/STAT1 axis. +lncRNA target 32504836 hsa-mir-142 Stomach Neoplasms 5p, which further led to the upregulation of migration suppressor CD9, a newly identified target of miR +other 32504622 hsa-mir-103 Polycystic Ovary Syndrome RESULTS: miR-103 was correlated with BMI rather than testosterone (T), and there was a significant difference between the non-obese and obese groups in miR-103 expression. There was significant difference between the non-obese and obese groups in miR-103 expression. +circulation_biomarker_diagnosis_ns 32504411 hsa-mir-34a Sarcoma, Ewing Although this analysis should be extended to a larger cohort of patients, these findings imply that detection of the miR34a levels in the blood of EWS patients may assist with the clinical management of EWS. +other 32504357 hsa-mir-125a Stomach Neoplasms PURPOSE: The aim of this study was to evaluate the expression of miR-125a-5p in patients with dyspeptic symptoms and gastric cancer, correlating them with the development of this cancer and H. +other 32504357 hsa-mir-125a Gastritis PURPOSE: The aim of this study was to evaluate the expression of miR-125a-5p in patients with dyspeptic symptoms and gastric cancer, correlating them with the development of this cancer and H. +lncRNA target 32504353 hsa-mir-139 Stomach Neoplasms 3p, which may function as an effective gene target for managing GC. +genetics_overexpression_suppress 32504285 hsa-mir-4270 Carcinoma, Hepatocellular The rescue experiments suggested that SATB2 overexpression reversed the biological function of miR +lncRNA target 32504027 hsa-mir-141 Diabetic Nephropathies Taken these together, we revealed for the first time that SNHG16 induced proliferation and fibrogenesis via modulating miR +lncRNA target 32503944 hsa-mir-340 Pancreatic Carcinoma The restoration of miR-340 expression in pancreatic cancer cells was sufficient to downregulate CD47 and promote phagocytosis of macrophages, further inhibiting tumor growth. +genetics_overexpression_promote 32503653 hsa-mir-518a Ovarian Neoplasms Furthermore, overexpression of circ_0078607 could inhibit the proliferation and invasion of ovarian cancer cells caused by miR-518a-5p mimic. +genetics_overexpression_suppress 32503577 hsa-mir-874 Stomach Neoplasms miR-874 overexpression in GC cells led to inhibition of cell proliferation and induction of apoptosis. +other 32503403 hsa-mir-125b Arthritis, Rheumatoid According to the results obtained, a comparative correlation between negative expression of the vitamin D receptor (VDR) and miR-125b was suggested in RA. +other 32502839 hsa-mir-34a Esophageal Squamous Cell Carcinoma Taken together, our findings revealed that MIR31HG promotes ESCC progression by regulating miR-34a/ c-Met axis and may provide a new prospective for exploration and understanding of the biological effects of esophageal squamous cell carcinoma. +other 32502839 hsa-mir-1 Esophageal Squamous Cell Carcinoma Taken together, our findings revealed that MIR31HG promotes ESCC progression by regulating miR-34a/ c-Met axis and may provide a new prospective for exploration and understanding of the biological effects of esophageal squamous cell carcinoma. +lncRNA target 32502567 hsa-mir-9 Brain Injuries, Traumatic 5p may be a potential new therapeutic target for TBI. +other 32502543 hsa-mir-34a Glioma In glioma cells, sevoflurane up-regulated miR-34a-5p abundance and down-regulated MMP-2 level. +lncRNA target 32502201 hsa-mir-27a Hemangioma, Cavernous, Central Nervous System Our work has established that VE-cadherin is a potential therapeutic target for normalization of the vasculature and highlights that targeting miR-27a/VE-cadherin interaction by CD5-2 is a potential novel therapy for the devastating disease, CCM. +lncRNA target 32501997 hsa-mir-10b Stomach Neoplasms In conclusion, miR-10b acts as a tumor suppressor with prognostic and diagnostic values for GC. +genetics_overexpression_promote 32501811 hsa-mir-623 Breast Neoplasms METHODS: miR-623 was either overexpressed in breast cancer cell lines through exogenous transfection or knocked down by specific siRNA. +other 32500915 hsa-mir-486 Urinary Bladder Neoplasms Therefore, MIR22HG regulates miR-486/PTEN axis to promote cell proliferation in BC. +other 32500915 hsa-mir-22 Urinary Bladder Neoplasms We analyzed the TCGA dataset and found the down-regulation of MIR22HG in bladder cancer (BC). +epigenetics 32500672 hsa-mir-132 Adenocarcinoma of Lung 3p-3p downregulation via DNA methylation promoted tumorigenicity of lung cancer by directly regulating ZEB2. +lncRNA target 32500475 hsa-mir-149 Angelman Syndrome In this report, we concluded the promoted role of circ_0124644 in the ox-LDL-induced endothelial injury of HUVECs via the miR5p/PAPP-A axis with an emphasis on its diagnostic and therapeutic values in AS. +genetics_overexpression_promote 32500444 hsa-mir-1233 Thyroid Neoplasms CONCLUSION: In thyroid cancer, overexpressed circTP53 decreased the protein level of p53 via targeting miR3p/MDM2 axis and promoted cancer cell proliferation. +lncRNA target 32500307 hsa-mir-128 Sepsis 3p targets NRP1 for cell degradation, promotes inflammatory cell infiltration, increases expression of inflammatory factors, decreases renal cell viability, and increases apoptosis in LPS-induced septic acute renal injury. +lncRNA target 32500307 hsa-mir-128 Acute Kidney Injury 3p targets NRP1 for cell degradation, promotes inflammatory cell infiltration, increases expression of inflammatory factors, decreases renal cell viability, and increases apoptosis in LPS-induced septic acute renal injury. +target gene 32499818 hsa-mir-532 Breast Neoplasms CircRNA_103809 Suppresses the Proliferation and Metastasis of Breast Cancer Cells by Sponging MicroRNA-532-3p (miR-532-3p). +lncRNA target 32499696 hsa-mir-8081 Osteosarcoma Taken together, a newly identified regulatory mechanism of the lncRNA NR_136400/miR-8081/TUSC5 axis was systematically studied in OS, providing a promising target for therapeutic treatment. +circulation_biomarker_diagnosis_ns 32499563 hsa-mir-379 Muscular Dystrophy, Duchenne Of these, we selected miR-379 for a detailed investigation because its expression is high in the muscle, and is known to be responsive to glucocorticoid, a class of anti-inflammatory drugs commonly used in DMD patients. Furthermore, miR-379 seric level, which is also elevated in the plasma of DMD patients in comparison with age-matched controls, is reduced by GC treatment. +other 32499481 hsa-mir-199a Liver Cirrhosis Our findings highlight the therapeutic potential of miR-199a-3p for hepatic fibrosis. +other 32499446 hsa-mir-520a Carcinoma, Non-Small-Cell Lung Mechanistically, we demonstrated that silencing circ-SEC31A downregulated GOT-2 expression by relieving the sponging effect of miR-520a-5p, which resulted in significantly reduced malate-aspartate metabolism in NSCLC cells. +other 32499335 hsa-mir-155 Asthma The proinflammatory microRNA-155 is crucial in a murine model of TDI asthma, suggesting its involvement in the pathogenesis of occupational asthma due to low molecular weight agents. +lncRNA target 32498943 hsa-mir-294 Carcinoma, Hepatocellular Furthermore, HCC cells were treated with JNK inhibitor SP600125 or ERK inhibitor U0126 and transfected with miR-294 mimics or negative control. +other 32498701 hsa-mir-210 Diabetic Retinopathy The regulatory effect of miR-210 on vascular endothelial cell proliferation under high-glucose condition, indicating its therapeutic potential in the treatment of diabetic vascular diseases. +exosome 32498409 hsa-mir-1293 Carcinoma, Renal Cell Taken together, these results suggest that EVs content varies depending on the presence or absence of the disease and that an increase of EV-derived hsa-miR-301a-3p, and decrease of EV-derived hsa-miR-1293, may be potential biomarkers of metastatic ccRCC. +lncRNA target 32498294 hsa-mir-137 Arthritis, Rheumatoid CONCLUSIONS: microRNA-137 plays an important role in PMs-induced RA acute exacerbation through MAPK signaling pathways and IL-6/COX-II activation. +lncRNA target 32497621 hsa-mir-200c Ovarian Neoplasms This study demonstrated that silencing of TMPO-AS1 might attenuate OC progression through inhibiting the invasion, metastasis and drug resistance of OC cells via the miR-200c/TMEFF2 network and the disruption of the PI3K/Akt signaling pathway. +lncRNA target 32497406 hsa-mir-27a Osteomyelitis Treatment with algal extract significantly restored LPS-suppressed bone mineralization and the mRNA expression levels of osteoblast-specific genes such as runt-related transcription factor 2 (Runx2), alkaline phosphatase (ALP) and osteocalcin (OCN), osteopontin (OPN), miR-27a and miR-29b. +lncRNA target 32497406 hsa-mir-29b Osteomyelitis Treatment with algal extract significantly restored LPS-suppressed bone mineralization and the mRNA expression levels of osteoblast-specific genes such as runt-related transcription factor 2 (Runx2), alkaline phosphatase (ALP) and osteocalcin (OCN), osteopontin (OPN), miR-27a and miR-29b. +other 32497022 hsa-mir-193a Breast Neoplasms The potential molecular mechanism of SNHG1 in breast cancer cells may involve SNHG1 acting as a sponge of miR-193a-5p to activate the expression of the oncogene HOXA1. In summary, our study reveals a novel SNHG1/miR-193a-5p/HOXA1 competing endogenous RNA regulatory pathway in breast cancer progression and may provide new strategies for breast cancer therapy. +circRNA target 32497020 hsa-mir-520b Triple Negative Breast Neoplasms Therefore, our work uncovers the mechanism by which circIFI30 could promote TNBC progression through circIFI30/miR-520b-3p/CD44 axis and circIFI30 could be a novel diagnostic/prognostic marker and therapeutic target for TNBC patients. +genetics_GWAS 32496828 hsa-mir-4293 Lung Neoplasms Results from GO items and KEGG pathway analysis illustrated that myeloid cell development, transcription factor complex, RNA polymerase II regulatory region DNA binding were regulated by miR-4293.Conclusion: In summary, our meta-analysis chase down heterozygote rs12220909 polymorphism of miR-4293 is a protective factor to cancer initiation, especially for lung cancer. +genetics_knock down_suppress 32496549 hsa-mir-204 Stomach Neoplasms 5p inhibitor weakened the inhibition of circSLAMF6 knockdown on GC cell progression under hypoxia. +lncRNA target 32495982 hsa-mir-198 Esophageal Squamous Cell Carcinoma MET signal axis to promote the migration, invasion, and metastasis of esophageal cancer cells, which can thereby serve as a potential diagnostic and therapeutic target of esophageal cancer. +genetics_knock down_promote 32495922 hsa-mir-29a Squamous Cell Carcinoma of Head and Neck In addition, loss-of-function experiments demonstrated that SNHG20 knockdown inhibited the development and progression of OSCC, whereas the miR-29a inhibitor significantly abolished the effect of SNHG20 depletion on OSCC progression by directly binding to SNHG20. +transcription factor target 32495894 hsa-mir-201 Acute Kidney Injury CONCLUSIONS: The novel role of miR5p via the inhibition of LPS-activated TLR4/NOTCH3 might provide a potential therapeutic strategy for the treatment of LPS-induced AKI. +transcription factor target 32495889 hsa-mir-449b Glioblastoma CONCLUSIONS: MiR-449b-5p acts as a tumor suppressor and retards the oncogenesis of glioblastoma, which is achieved via inactivation of Wnt/beta-catenin signaling by directly targeting WNT2B. +genetics_overexpression_promote 32495888 hsa-mir-761 Glioma Moreover, both miR-761 overexpression and TGIF2 suppression restored circ_0012129 enhancement-mediated biological characteristics of sevoflurane-treated glioma cells. +other 32495887 hsa-mir-424 Neuroblastoma The newly identified miR-424/DCLK1 axis provides novel insights into the pathogenesis of neuroblastoma. +lncRNA target 32495886 hsa-mir-200c Thyroid Cancer, Papillary OBJECTIVE: To investigate the potential effects of miR-200c on proliferation and apoptosis of papillary thyroid cancer (PTC) cells. CONCLUSIONS: MiR-200c is a tumor suppressor miRNA, which promotes proliferation of PTC cells and activates Wnt/beta-catenin signaling pathway by directly regulating the corresponding target protein, DACH1. +other 32495884 hsa-mir-328a Breast Neoplasms CONCLUSIONS: LncRNA APPAT regulated the proliferation, migration, invasion of breast cancer by regulating miR-328a/Pkp1 signaling pathway, providing a novel possible strategy for the treatment of breast cancer. +lncRNA target 32495883 hsa-mir-326 Triple Negative Breast Neoplasms RESULTS: We found that the expression of SNHG3 and ITGA5 was upregulated and miR-326 was downregulated in TNBC tumors and cell lines (MDA-MB-231, BT-549, MDA-MB-468 and SUM159). CONCLUSIONS: Silencing of SNHG3 suppressed the malignant development of TNBC cells, at least partially, through miR-326/ITGA5 axis and inhibiting Vav2/Rac1 signaling pathway. +circulation_biomarker_prognosis_up 32495876 hsa-mir-182 Esophageal Squamous Cell Carcinoma CONCLUSIONS: Collectively, serum exosomal miR-182 might serve as a promising biomarker for predicting the unfavorable prognosis of ESCC. +genetics_knock down_promote 32495871 hsa-mir-140 Colorectal Neoplasms 3p exerted similar effects to those of visfatin knockdown on the proliferation and invasion of CRC cells. +lncRNA target 32495866 hsa-mir-203a Wilms Tumor By negatively regulating JAG1, miRNA-203a-5p alleviates the malignant progression of WT. +genetics_overexpression_promote 32495862 hsa-mir-18a Ovarian Neoplasms Overexpression of miR-18a in OC cells could prominently suppress the proliferation, migration and invasion abilities via modulating ERK/MAPK pathway and epithelial-to-mesenchymal transition (EMT). +genetics_knock down_promote 32495861 hsa-mir-652 Ovarian Neoplasms Finally, it was found that simultaneous knockdown of circRNA_MYKK and microRNA-652 could reverse the enhanced OC cell proliferative capacity induced by downregulation of circRNA_MYLK alone. +circulation_biomarker_diagnosis_up 32495855 hsa-mir-203a Pre-Eclampsia RESULTS: Compared with normal pregnant volunteers, microRNA-203a-3p expression in serum exosomes and placental mononuclear cells of PE patients were dramatically reduced, while IL24 was conversely up-regulated, indicating a negative correlation between microRNA-203a-3p and IL24 levels. +lncRNA target 32495824 hsa-mir-205 Keloid CONCLUSION: CACNA1G-AS1 suppressed miR-205 expression to promote proliferation and invasion and inhibit apoptosis in human keloid fibroblasts. +other 32495625 hsa-mir-182 Multiple Sclerosis Herein, the gate is functionalized with a genomic biomarker for multiple sclerosis (miR-182). +genetics_overexpression_suppress 32495614 hsa-mir-23b Carcinoma, Non-Small-Cell Lung Furthermore, functional assays demonstrated that overexpression of miR-23b inhibited NSCLC cell viability, invasion and migration. +transcription factor target 32495507 hsa-mir-200b Colorectal Neoplasms Furthermore, HNF-1beta inhibits the stemness and migration of colorectal cancer cells through miR-200b. This study reveals a novel HNF-1beta/miR-200b axis responsible for the stemness of colorectal cancer cells. +transcription factor target 32495394 hsa-mir-124 Thyroid Cancer, Papillary 3p inhibited the proliferation and motility, and induced apoptosis and cell cycle arrest in PTC cells. +other 32495225 hsa-mir-21 Tooth, Impacted conventional extraction of impacted lower third molar was significantly associated with expression of bone miR-21. +transcription factor target 32494663 hsa-mir-26a Prostatic Neoplasms By using this method, we identified miR-26a involved in EV secretion from prostate cancer (PCa) cells. Together, our findings suggest that miR-26a regulates EV secretion via targeting SHC4, PFDN4, and CHORDC1 in PCa cells, resulting in the suppression of PCa progression. +other 32494206 hsa-mir-608 Glioma CONCLUSION: In the present study, a novel established functional manner of TSN/miR-608/Notch1 (Notch2) axis was systematically indicated, which might provide prospective intervention ways for glioma therapy. +other 32494204 hsa-mir-34a Squamous Cell Carcinoma of Head and Neck CONCLUSION: LUADT1 may promote OSCC proliferation by regulating miR-34a/GAS1 axis. +lncRNA target 32494200 hsa-mir-765 Colorectal Neoplasms CONCLUSION: Our results demonstrated that LINC00173 plays an important oncogenic role in CRC via modulating miR-765/PLP2 axis. +other 32494199 hsa-mir-766 Urinary Bladder Neoplasms LINC00963 Functions as an Oncogene in Bladder Cancer by Regulating the miR-766-3p/MTA1 Axis. +target gene 32494198 hsa-mir-340 Glioblastoma Upregulation of miR-340 Inhibits Tumor Growth and Mesenchymal Transition via Targeting c-MET in Glioblastoma. +lncRNA target 32494163 hsa-mir-766 Carcinoma, Squamous Cell, Cutaneous CONCLUSION: MiR-766 inhibitor inhibited the proliferation, migration and invasion, and promoted the apoptosis of CSCC cells via downregulating PDCD5. +other 32494162 hsa-mir-153 Triple Negative Breast Neoplasms MiR-153-5p Enhances the Sensitivity of Triple-Negative Breast Cancer Cells to Paclitaxel by Inducing G2M Phase Arrest. +lncRNA target 32494160 hsa-mir-383 Glioma CONCLUSION: CIP2A plays a carcinogenesis role in glioma progression and is one of the potential targets of miR-383. +lncRNA target 32494158 hsa-mir-145 Colorectal Neoplasms 5p/IGF1 signaling pathway and may have potential use as a prognostic indicator and therapeutic target in CRC patients. +lncRNA target 32494153 hsa-mir-365a Stomach Neoplasms The involvement of microRNA-365a-3p (miR-365a-3p) and ATP-binding cassette subfamily C member 4 (ABCC4) in the biological roles of NEAT1 in GC progression was validated by luciferase activity reporter assay and rescue experiments. CONCLUSION: In this study, we revealed a NEAT1/miR-365a-3p/ABCC4 triplet in GC progression, which may provide novel targeted therapy markers for GC. +other 32494004 hsa-mir-490 Carcinoma, Non-Small-Cell Lung Meanwhile, we found that hsa_circRNA_101237 expression sponged miR3p to enhance MAPK1 expression, thus significantly promoting NSCLC cell lines proliferation, migration, and invasion. +circulation_biomarker_diagnosis_ns 32493989 hsa-mir-29a Uterine Cervical Neoplasms To this end, we established a unique biomarker panel in this study, which determined both squamous cell carcinoma antigen (SCC Ag) degree and miRNA-29a, miRNA-25, miRNA5p levels in blood for detection of early-stage cervical cancer. +circulation_biomarker_diagnosis_ns 32493989 hsa-mir-25 Uterine Cervical Neoplasms To this end, we established a unique biomarker panel in this study, which determined both squamous cell carcinoma antigen (SCC Ag) degree and miRNA-29a, miRNA-25, miRNA5p levels in blood for detection of early-stage cervical cancer. +circulation_biomarker_diagnosis_ns 32493989 hsa-mir-486 Uterine Cervical Neoplasms To this end, we established a unique biomarker panel in this study, which determined both squamous cell carcinoma antigen (SCC Ag) degree and miRNA-29a, miRNA-25, miRNA5p levels in blood for detection of early-stage cervical cancer. +lncRNA target 32493932 hsa-mir-16 Breast Neoplasms 5p, which targets cell cycle related genes and predicts longer overall survival of breast cancer patients, as determined by bioinformatics analysis. +genetics_overexpression_promote 32493835 hsa-mir-342 Carcinoma, Hepatocellular 3p and overexpression of AGR2 promoted the progression of HCC. +other 32493793 hsa-mir-126 Atherosclerosis In human plaques, we found reduced nuclear miR5p and active caspase-3 in areas of disturbed flow. +lncRNA target 32493727 hsa-mir-197 Malaria Overall, this study identifies apicortin as a novel target within the malaria parasite and establishes miR5p as its miRNA inhibitor. +genetics_overexpression_promote 32493490 hsa-mir-29b Hepatoblastoma Besides, we identified that STAT3 overexpression partially rescued silenced circ_0043800, while miR-29a/b/c-3p inhibition completely rescued silenced circ_0043800 on HB cellular biological behaviors. CONCLUSION: Gli2-induced circ_0043800 served as the ceRNA to promote HB by up-regulation of STAT3 and Gli2 at a miR-29a/b/c-3p dependent manner. +genetics_overexpression_promote 32493490 hsa-mir-29c Hepatoblastoma Besides, we identified that STAT3 overexpression partially rescued silenced circ_0043800, while miR-29a/b/c-3p inhibition completely rescued silenced circ_0043800 on HB cellular biological behaviors. CONCLUSION: Gli2-induced circ_0043800 served as the ceRNA to promote HB by up-regulation of STAT3 and Gli2 at a miR-29a/b/c-3p dependent manner. +genetics_overexpression_promote 32493490 hsa-mir-29a Hepatoblastoma Besides, we identified that STAT3 overexpression partially rescued silenced circ_0043800, while miR-29a/b/c-3p inhibition completely rescued silenced circ_0043800 on HB cellular biological behaviors. CONCLUSION: Gli2-induced circ_0043800 served as the ceRNA to promote HB by up-regulation of STAT3 and Gli2 at a miR-29a/b/c-3p dependent manner. +lncRNA target 32493389 hsa-mir-326 Carcinoma, Non-Small-Cell Lung circSATB2 positively regulated fascin homolog 1, actin-bundling protein 1 (FSCN1) expression via miR-326 in lung cancer cells. +lncRNA target 32493303 hsa-mir-106 Colorectal Neoplasms Then, we qualitatively explored the biomarker roles of miR-106 in CRC through an integrative bioinformatics analysis. +transcription factor target 32492888 hsa-mir-381 Osteoarthritis We also found that resistin affects VCAM-1 expression and monocyte adhesion in human OASFs by inhibiting miR-381 synthesis via the PKCalpha, p38, and JNK signaling pathways. +other 32492882 hsa-mir-20a Breast Neoplasms Low Expression of miR-20a-5p Predicts Benefit to Bevacizumab in Metastatic Breast Cancer Patients Treated within the TANIA Phase III Trial. +transcription factor target 32492770 hsa-mir-23a Colorectal Neoplasms Therefore, we aimed to investigate the effect of IL-17C on tumor angiogenesis, the involvement of miR-23a-3p in IL-17C signaling, and the direct target gene of miR-23a-3p in CRC. Taken together, our study demonstrates that IL-17C promotes tumor angiogenesis through VEGF production via a STAT3/miR-23a-3p/SEMA6D axis, suggesting its potential as a novel target for anti-CRC therapy. +lncRNA target 32492708 hsa-mir-486 Thyroid Neoplasms By suppressing miR3p, PMN-MDSCs promote the activity of the NF-kappaB2 signaling pathway, resulting in accelerated invasion of PTC cells, which may provide new therapeutic strategies for treatment of thyroid cancer. +circulation_biomarker_diagnosis_ns 32492657 hsa-mir-195 Acute Kidney Injury 5p levels were decreased in the serum samples of patients with AKI. +lncRNA target 32492291 hsa-mir-144 Parkinson Disease In conclusion, we identified that the downregulation of miR-218, miR-124, and miR-144 in the brain was related to PD via activation of NF-kappaB signaling, helping to unveil the role played by dysregulated miRNAs in the pathogenesis of PD and provide new potential targets for PD treatment. +lncRNA target 32492291 hsa-mir-218 Parkinson Disease In conclusion, we identified that the downregulation of miR-218, miR-124, and miR-144 in the brain was related to PD via activation of NF-kappaB signaling, helping to unveil the role played by dysregulated miRNAs in the pathogenesis of PD and provide new potential targets for PD treatment. +lncRNA target 32492291 hsa-mir-124 Parkinson Disease In conclusion, we identified that the downregulation of miR-218, miR-124, and miR-144 in the brain was related to PD via activation of NF-kappaB signaling, helping to unveil the role played by dysregulated miRNAs in the pathogenesis of PD and provide new potential targets for PD treatment. +genetics_overexpression_promote 32492286 hsa-mir-559 Carcinoma, Hepatocellular These results demonstrated that low-level expression of miR-559 was associated with HCC, and overexpression of miR-559 could inhibit HCC cell growth and invasion via targeting GP73. +transcription factor target 32492224 hsa-mir-195 Mycosis Fungoides 5p in MF inhibits cycle arrest by downregulation of ARL2. +genetics_GWAS 32492046 hsa-mir-182 Glaucoma, Open-Angle Therefore, both rs76481776 polymorphism in miR182 gene and rs3217992 polymorphism in CDKN2B gene seem to be associated with the development of POAG in a Greek population. +lncRNA target 32491925 hsa-mir-135b Diabetic Retinopathy Our results highlight the suppressor role played by miR-135b in CP by inducing NSC differentiation via inactivation of S100B-dependent STAT3 pathway. +lncRNA target 32491925 hsa-mir-135b Cerebral Palsy Our results highlight the suppressor role played by miR-135b in CP by inducing NSC differentiation via inactivation of S100B-dependent STAT3 pathway. +lncRNA target 32491253 hsa-mir-223 Uterine Cervical Neoplasms miR-223 targeted the 3'-UTRs of TGFBR3 and HMGCS1 and suppressed their expression, leading to increased anchorage-independent growth and cervical squamous cell carcinoma (CSCC) tumor growth in vitro and in vivo. +circulation_biomarker_diagnosis_ns 32490854 hsa-mir-96 Urinary Bladder Neoplasms As a proof of concept, microRNA-10b and microRNA-96 were directly assayed from the plasma of six bladder cancer patients. +circulation_biomarker_diagnosis_ns 32490854 hsa-mir-10b Urinary Bladder Neoplasms As a proof of concept, microRNA-10b and microRNA-96 were directly assayed from the plasma of six bladder cancer patients. +other 32490599 hsa-mir-146 Anemia, Aplastic 5p, miR-146b-5p, miR-34a, miR-29a, and miR-29b was evaluated in the bone marrow mononuclear cells of aAA patients. +other 32490599 hsa-mir-150 Anemia, Aplastic 5p, miR-146b-5p, miR-34a, miR-29a, and miR-29b was evaluated in the bone marrow mononuclear cells of aAA patients. +other 32490599 hsa-mir-126 Anemia, Aplastic 5p, miR-146b-5p, miR-34a, miR-29a, and miR-29b was evaluated in the bone marrow mononuclear cells of aAA patients. +other 32490599 hsa-mir-29a Anemia, Aplastic 5p, miR-146b-5p, miR-34a, miR-29a, and miR-29b was evaluated in the bone marrow mononuclear cells of aAA patients. +other 32490599 hsa-mir-146b Anemia, Aplastic 5p, miR-146b-5p, miR-34a, miR-29a, and miR-29b was evaluated in the bone marrow mononuclear cells of aAA patients. +other 32490599 hsa-mir-145 Anemia, Aplastic 5p, miR-146b-5p, miR-34a, miR-29a, and miR-29b was evaluated in the bone marrow mononuclear cells of aAA patients. +other 32490599 hsa-mir-34a Anemia, Aplastic 5p, miR-146b-5p, miR-34a, miR-29a, and miR-29b was evaluated in the bone marrow mononuclear cells of aAA patients. +other 32490599 hsa-mir-155 Anemia, Aplastic 5p, miR-146b-5p, miR-34a, miR-29a, and miR-29b was evaluated in the bone marrow mononuclear cells of aAA patients. +other 32490599 hsa-mir-29b Anemia, Aplastic 5p, miR-146b-5p, miR-34a, miR-29a, and miR-29b was evaluated in the bone marrow mononuclear cells of aAA patients. +genetics_GWAS 32490171 hsa-mir-155 Liver Neoplasms In conclusion, miR-155 can play a positive role in the development of liver cancer and influence a series of gene expression through epigenetic regulation. +lncRNA target 32489472 hsa-mir-204 Glioma XIST mediated glioma progression by targeting miR +other 32489471 hsa-mir-103a Prostatic Hyperplasia In the subsequent qRT-PCR analysis, the let-7f-5p was upregulated in PCa compared with BPH patients (P=2.17E-07), but no statistically difference of miR-103a-3p expression was observed (P=0.456). +other 32489471 hsa-mir-103a Prostatic Neoplasms In the subsequent qRT-PCR analysis, the let-7f-5p was upregulated in PCa compared with BPH patients (P=2.17E-07), but no statistically difference of miR-103a-3p expression was observed (P=0.456). +circulation_biomarker_diagnosis_up 32489471 hsa-let-7f Prostatic Neoplasms Conclusions: Our study suggests that plasma let-7f-5p combining PSA could serve as potentially diagnostic biomarkers for PCa. +circulation_biomarker_diagnosis_up 32489471 hsa-let-7f Prostatic Hyperplasia Conclusions: Our study suggests that plasma let-7f-5p combining PSA could serve as potentially diagnostic biomarkers for PCa. +target gene 32489464 hsa-mir-223 Prostatic Neoplasms miR-223-5p targeting ERG inhibits prostate cancer cell proliferation and migration. +lncRNA target 32489462 hsa-mir-206 Colorectal Neoplasms Overall, this study firstly elucidated that LncHOTAIR played as oncogene in CRC via directly sponging miR-206 to activate the downstream CCL2, which would be considered as the novel therapeutic target in CRC. +genetics_knock down_suppress 32489326 hsa-mir-186 Uterine Cervical Neoplasms Furthermore, restoration experiments showed NNT-AS1 knockdown might improve DDP-sensitivity of CC cells via blocking HMGB1 expression by competitive interaction with miR-186. CONCLUSION: NNT-AS1 improved chemoresistance of DDP-resistant CC cells via modulating miR-186/HMGB1 axis. +other 32489325 hsa-mir-24 Hemangioma Mechanistically, FOXD2-AS1 inversely regulated miR3p abundance in hemangioma cells. +genetics_overexpression_promote 32489316 hsa-mir-942 Carcinoma, Non-Small-Cell Lung Overexpression of miR +other 32489289 hsa-mir-223 Glomerulonephritis, IGA There was a positive correlation between miRNA-223 and NLRP3 expression and 24-hour urinary protein in IgA nephropathy. +other 32488785 hsa-mir-146a Stomach Neoplasms A correlation was found between the expression of miR-34a and miR-146a during metastasis, which is absent in non-metastatic tumors. +other 32488785 hsa-mir-34a Stomach Neoplasms A correlation was found between the expression of miR-34a and miR-146a during metastasis, which is absent in non-metastatic tumors. +other 32488785 hsa-mir-335 Stomach Neoplasms Thus, miR-34a, miR-146a, and miR-335 miRNAs can be proposed as candidates for biomarkers of the risk of gastric cancer metastasis. +circulation_biomarker_diagnosis_ns 32488579 hsa-mir-509 Azoospermia, Nonobstructive 5p, miR-34b-3p, miR-34c-5p) in the seminal plasma of patients with obstructive azoospermia, non-obstructive azoospermia and Klinefelter syndrome. +circulation_biomarker_diagnosis_ns 32488579 hsa-mir-34b Azoospermia, Nonobstructive 5p, miR-34b-3p, miR-34c-5p) in the seminal plasma of patients with obstructive azoospermia, non-obstructive azoospermia and Klinefelter syndrome. +circulation_biomarker_diagnosis_ns 32488579 hsa-mir-122 Azoospermia, Nonobstructive 5p, miR-34b-3p, miR-34c-5p) in the seminal plasma of patients with obstructive azoospermia, non-obstructive azoospermia and Klinefelter syndrome. +circulation_biomarker_diagnosis_ns 32488579 hsa-mir-34c Azoospermia, Nonobstructive 5p, miR-34b-3p, miR-34c-5p) in the seminal plasma of patients with obstructive azoospermia, non-obstructive azoospermia and Klinefelter syndrome. +other 32488542 hsa-mir-122 Liver Diseases Graphical abstract Schematic representation of three-dimensional (3D) DNA walker constructed using catalytic hairpin self-assembly reaction (CHA)-assisted amplification and ratiometric fluorescence signal output for the detection of miRNA-122 closely related to hepatitis. +other 32488386 hsa-let-7a Lung Neoplasms In this work, a duplex-specific nuclease (DSN)-resistant triplex-helix DNA nanoswitch was designed for assays of single-base differentiation of the let-7a family in lung cancer cells. +lncRNA target 32488063 hsa-mir-342 Neurotoxicity Syndromes Globally, our findings show that miR-342 is a crucial mediator of TNF-alpha-mediated microglia activation and a potential target to tackle microglia-driven neuroinflammation. +circulation_biomarker_diagnosis_ns 32487978 hsa-mir-146a Stomach Neoplasms RESULTS Significant differences in the plasma expression levels of miR-19a-3p, miR +circulation_biomarker_diagnosis_ns 32487978 hsa-mir-483 Stomach Neoplasms CONCLUSIONS Plasma miR-19a-3p and miR +circulation_biomarker_diagnosis_ns 32487978 hsa-mir-22 Stomach Neoplasms RESULTS Significant differences in the plasma expression levels of miR-19a-3p, miR +circulation_biomarker_diagnosis_ns 32487978 hsa-mir-19a Stomach Neoplasms CONCLUSIONS Plasma miR-19a-3p and miR +circulation_biomarker_diagnosis_up 32487772 hsa-mir-223 Ullrich congenital muscular dystrophy Subsequent validation in serum from patients with UCAD, SCAD, SubA and controls demonstrated significant upregulation of miR +other 32487772 hsa-mir-193b Cumulative Trauma Disorders 3p were most upregulated in patients with UCAD. +circulation_biomarker_diagnosis_up 32487772 hsa-mir-133a Coronary Artery Disease Subsequent validation in serum from patients with UCAD, SCAD, SubA and controls demonstrated significant upregulation of miR +other 32487772 hsa-mir-499 Ischemia The ischaemia-related miR5p was also highly upregulated in patients with UCAD compared with the other groups (SCAD OR 20.63 (95% CI 11.16 to 38.15), SubA OR 96.10 (95% CI 40.13 to 230.14) and controls OR 15.73 (95% CI 7.80 to 31.72)). +other 32487772 hsa-mir-499 Coronary Artery Disease 5p expression was observed across SCAD, SubA and controls. +other 32487772 hsa-mir-499 Cumulative Trauma Disorders 5p expression was observed across SCAD, SubA and controls. +other 32487772 hsa-mir-499 Miliaria 5p expression was observed across SCAD, SubA and controls. +circulation_biomarker_diagnosis_up 32487772 hsa-mir-223 Miliaria Subsequent validation in serum from patients with UCAD, SCAD, SubA and controls demonstrated significant upregulation of miR +circulation_biomarker_diagnosis_up 32487772 hsa-mir-122 Ullrich congenital muscular dystrophy MiR5p was the only miRNA to be significantly upregulated in the serum of both patients with UCAD and SCAD. +other 32487772 hsa-mir-499 Ullrich congenital muscular dystrophy The ischaemia-related miR5p was also highly upregulated in patients with UCAD compared with the other groups (SCAD OR 20.63 (95% CI 11.16 to 38.15), SubA OR 96.10 (95% CI 40.13 to 230.14) and controls OR 15.73 (95% CI 7.80 to 31.72)). +circulation_biomarker_diagnosis_up 32487772 hsa-mir-223 Cumulative Trauma Disorders Subsequent validation in serum from patients with UCAD, SCAD, SubA and controls demonstrated significant upregulation of miR +other 32487772 hsa-mir-125b Coronary Artery Disease 3p were most upregulated in patients with UCAD. +circulation_biomarker_diagnosis_up 32487772 hsa-mir-133a Miliaria Subsequent validation in serum from patients with UCAD, SCAD, SubA and controls demonstrated significant upregulation of miR +circulation_biomarker_diagnosis_up 32487772 hsa-mir-133a Cumulative Trauma Disorders Subsequent validation in serum from patients with UCAD, SCAD, SubA and controls demonstrated significant upregulation of miR +other 32487772 hsa-mir-193b Ullrich congenital muscular dystrophy 3p were most upregulated in patients with UCAD. +circulation_biomarker_diagnosis_up 32487772 hsa-mir-146 Ullrich congenital muscular dystrophy Subsequent validation in serum from patients with UCAD, SCAD, SubA and controls demonstrated significant upregulation of miR +other 32487772 hsa-mir-125b Cumulative Trauma Disorders 3p were most upregulated in patients with UCAD. +circulation_biomarker_diagnosis_up 32487772 hsa-mir-133a Ullrich congenital muscular dystrophy Subsequent validation in serum from patients with UCAD, SCAD, SubA and controls demonstrated significant upregulation of miR +circulation_biomarker_diagnosis_up 32487772 hsa-mir-146 Coronary Artery Disease Subsequent validation in serum from patients with UCAD, SCAD, SubA and controls demonstrated significant upregulation of miR +circulation_biomarker_diagnosis_up 32487772 hsa-mir-146 Cumulative Trauma Disorders Subsequent validation in serum from patients with UCAD, SCAD, SubA and controls demonstrated significant upregulation of miR +circulation_biomarker_diagnosis_up 32487772 hsa-mir-146 Miliaria Subsequent validation in serum from patients with UCAD, SCAD, SubA and controls demonstrated significant upregulation of miR +circulation_biomarker_diagnosis_up 32487772 hsa-mir-223 Coronary Artery Disease Subsequent validation in serum from patients with UCAD, SCAD, SubA and controls demonstrated significant upregulation of miR +other 32487772 hsa-mir-193b Coronary Artery Disease 3p were most upregulated in patients with UCAD. +circulation_biomarker_diagnosis_up 32487772 hsa-mir-155 Coronary Artery Disease Subsequent validation in serum from patients with UCAD, SCAD, SubA and controls demonstrated significant upregulation of miR +circulation_biomarker_diagnosis_up 32487772 hsa-mir-155 Cumulative Trauma Disorders Subsequent validation in serum from patients with UCAD, SCAD, SubA and controls demonstrated significant upregulation of miR +circulation_biomarker_diagnosis_up 32487772 hsa-mir-155 Miliaria Subsequent validation in serum from patients with UCAD, SCAD, SubA and controls demonstrated significant upregulation of miR +circulation_biomarker_diagnosis_up 32487772 hsa-mir-155 Ullrich congenital muscular dystrophy Subsequent validation in serum from patients with UCAD, SCAD, SubA and controls demonstrated significant upregulation of miR +circulation_biomarker_diagnosis_up 32487772 hsa-mir-122 Cumulative Trauma Disorders MiR5p was the only miRNA to be significantly upregulated in the serum of both patients with UCAD and SCAD. +circulation_biomarker_diagnosis_up 32487772 hsa-mir-122 Coronary Artery Disease MiR5p was the only miRNA to be significantly upregulated in the serum of both patients with UCAD and SCAD. +other 32487772 hsa-mir-125b Ullrich congenital muscular dystrophy 3p were most upregulated in patients with UCAD. +lncRNA target 32487755 hsa-mir-25 Tuberculosis 3p directly targets LNX1, an E3 ubiquitin ligase of NEK6, and that this hampers the proteasomal degradation of NEK6 in macrophages. +other 32487621 hsa-mir-221 Glioblastoma BACKGROUND/AIM: The aim of our study was to examine miRNA-221 as a candidate biomarker to define prognosis and/or classification for glial tumors. CONCLUSION: Increased expression levels of miRNA-221 could be a biomarker for glial tumors. +other 32487559 hsa-mir-204 Chronic Renal Injury 5p plays a prominent role in safeguarding the kidneys against common causes of chronic renal injury. +other 32487559 hsa-mir-204 Diabetes Mellitus 5p plays a prominent role in safeguarding the kidneys against common causes of chronic renal injury. +other 32487559 hsa-mir-204 Hypertension 5p plays a prominent role in safeguarding the kidneys against common causes of chronic renal injury. +genetics_GWAS 32487029 hsa-mir-203 Pemphigus, Benign Familial The study aim to detect novel mutations in exons of ATP2C1 gene in HHD patients; to explore the possible mechnism of HHD pathogenesis by examining the expression profile of hSPCA1, miR-203, p63, Notch1 and HKII proteins in the skin lesions of HHD patients. +genetics_overexpression_promote 32486927 hsa-mir-128 Liver Diseases Moreover, overexpression of Rnd3 could reverse the activation of NF-kappaB caused by miR +transcription factor target 32486841 hsa-mir-134 Carcinoma, Hepatocellular Conclusion: ESC suppressed HCC progression by upregulating the expression of miR +genetics_overexpression_promote 32486612 hsa-mir-216a Stomach Neoplasms Finally, in vitro cell experiments suggested that overexpression of TCTN1 could reverse the inhibitory impact of upregulation of microRNA-216a-5p on GC cell functions. +lncRNA target 32486604 hsa-mir-16 Osteosarcoma 5p inhibits the proliferation, migration and invasion of osteosarcoma cells by targeting the TSPAN15 gene and regulating the PI3K/AKT signaling pathway. +circulation_biomarker_diagnosis_up 32486598 hsa-mir-376b high grade glioma Conclusions: MiR-376b-3p is down-regulated in the serum exosomes of malignant glioma patients. +transcription factor target 32486489 hsa-mir-10b Glioblastoma Moreover, because of the therapeutic potential of using miR-10b inhibitors and of the broad expression of the Axl receptor in GBM, we used the GL21.T anti-Axl aptamer as the targeting moiety for anti-miR-10b, showing that, in combination with the STAT3 AsiC, the aptamer-miR-10b antagonist treatment further enhances the inhibition of GSC sphere formation. +lncRNA target 32485903 hsa-mir-1233 Alzheimer Disease 5p as a pathologic marker for Abeta(+)MCI. +other 32485570 hsa-mir-28 Breast Neoplasms 5p/CENPF axis accelerates breast cancer progression. +circulation_biomarker_diagnosis_ns 32485219 hsa-mir-133a Osteitis Deformans From those expression results, 3 miRNAs were further selected for in-vitro studies aiming at modulating miR expression in human cord blood monocyte derived osteoclasts: 2 miRs (miR-146a-3p and miR5p) whose expression was significantly reduced in pagetic osteoclasts, as well as miRNA-133a-3p, stable in PDB relative to controls, but with known regulatory importance within osteoclasts. +circulation_biomarker_diagnosis_ns 32485219 hsa-mir-146a Osteitis Deformans From those expression results, 3 miRNAs were further selected for in-vitro studies aiming at modulating miR expression in human cord blood monocyte derived osteoclasts: 2 miRs (miR-146a-3p and miR5p) whose expression was significantly reduced in pagetic osteoclasts, as well as miRNA-133a-3p, stable in PDB relative to controls, but with known regulatory importance within osteoclasts. +circulation_biomarker_diagnosis_ns 32485219 hsa-mir-155 Osteitis Deformans From those expression results, 3 miRNAs were further selected for in-vitro studies aiming at modulating miR expression in human cord blood monocyte derived osteoclasts: 2 miRs (miR-146a-3p and miR5p) whose expression was significantly reduced in pagetic osteoclasts, as well as miRNA-133a-3p, stable in PDB relative to controls, but with known regulatory importance within osteoclasts. +transcription factor target 32485091 hsa-mir-106b Periprosthetic Osteolysis Our findings indicated that miR-106b inhibition suppresses wear particles-induced osteolysis and bone destruction and thus may serve as a potential therapy for PPO and aseptic loosening. +transcription factor target 32485073 hsa-mir-676 Heart Failure In summary, our results contribute to identifying specific EV miRs for the potential therapeutic targets in heart failure and suggest that miR-676 as a new reference control for the EV miR studies. +lncRNA target 32485050 hsa-mir-18a Carcinoma, Basal Cell CONCLUSIONS: Our data support an oncogenic role of miR-18a through a novel Akt/mTOR/Beclin 1/LC3 axis, and suggest that the antitumour effects of miR-18a inhibitor may make it suitable for BCC therapy. +other 32485041 hsa-mir-145 Aortic Valve Disease The expression was validated by the qPCR approach in 46 AVs, 13 rheumatic, and 33 calcified AVs, confirming that miR5p, miR-199a-5p, and miR-5701 were significantly higher in rheumatic AVs as compared with calcified AVs. +other 32485041 hsa-mir-199a Aortic Valve Disease The expression was validated by the qPCR approach in 46 AVs, 13 rheumatic, and 33 calcified AVs, confirming that miR5p, miR-199a-5p, and miR-5701 were significantly higher in rheumatic AVs as compared with calcified AVs. +other 32485041 hsa-mir-5701 Aortic Valve Disease The expression was validated by the qPCR approach in 46 AVs, 13 rheumatic, and 33 calcified AVs, confirming that miR5p, miR-199a-5p, and miR-5701 were significantly higher in rheumatic AVs as compared with calcified AVs. +circulation_biomarker_prognosis_up 32484987 hsa-mir-126 Sepsis METHODS: Totally, 208 sepsis patients and 210 healthy controls were enrolled; then, their plasma samples were collected for detecting circulating miR-126 by quantitative polymerase chain reaction. +circulation_biomarker_prognosis_up 32484987 hsa-mir-126 Inflammation METHODS: Totally, 208 sepsis patients and 210 healthy controls were enrolled; then, their plasma samples were collected for detecting circulating miR-126 by quantitative polymerase chain reaction. +circulation_biomarker_diagnosis_ns 32484820 hsa-mir-155 Arthritis, Rheumatoid The evaluation of miR-155 host gene methylation status or miR155 plasma level might be a potentially useful marker in RA determination. +genetics_overexpression_promote 32484698 hsa-mir-125a Carcinoma, Hepatocellular Overexpression of miR-34a or miR-125a-5p restrained cell proliferation and metastasis while induced apoptosis by downregulating MACC1 in HCC cells. +genetics_overexpression_promote 32484698 hsa-mir-34a Carcinoma, Hepatocellular Overexpression of miR-34a or miR-125a-5p restrained cell proliferation and metastasis while induced apoptosis by downregulating MACC1 in HCC cells. +other 32484696 hsa-mir-874 Stomach Neoplasms TSN restrained the GC progression by regulating miR-874/HMGB2/beta-catenin pathways in vitro and in vivo. +other 32484213 hsa-mir-17 Carcinogenesis BACKGROUND: MiR-17 is a small noncoding RNA that plays an important role in the development of tumorgenesis, which recently has emerged to be involved in regulation of inflammatory responses and angiogenesis. +genetics_knock down_suppress 32484213 hsa-mir-17 Endometrial Hyperplasia CONCLUSIONS: Taken together, our results demonstrated that miR-17 knockdown accelerated VSMC phenotypic modulation partially through directly targeting to IRF9, which suggested that miR-17 may act as a novel therapeutic target for intimal hyperplasia management. +lncRNA target 32484209 hsa-mir-4269 Pancreatic Carcinoma Ultimately, our findings confirmed that miR-4269 served as a cancer suppressor in PC through regulation of ZEB1/OTX1 pathway, which suggested that miR-4269 might represent a promising target for the clinical treatment of PC. +lncRNA target 32484208 hsa-mir-27a Fibrosis, Renal This work aimed to investigate whether miR-27a can promote the occurrence of renal fibrosis in DN by suppressing the expression of secreted frizzled-related protein 1 (Sfrp1) to activate Wnt/beta-catenin signalling. We concluded that miR-27a down-regulated Sfrp1 and activated Wnt/beta-catenin signalling to promote renal fibrosis. +lncRNA target 32484208 hsa-mir-27a Diabetic Nephropathies This work aimed to investigate whether miR-27a can promote the occurrence of renal fibrosis in DN by suppressing the expression of secreted frizzled-related protein 1 (Sfrp1) to activate Wnt/beta-catenin signalling. We concluded that miR-27a down-regulated Sfrp1 and activated Wnt/beta-catenin signalling to promote renal fibrosis. +circulation_biomarker_diagnosis_ns 32484206 hsa-mir-204 Sepsis 5p expression in serum of sepsis patients. +lncRNA target 32484203 hsa-mir-141 Osteosarcoma 3p targets FUS to degrade LDHB, thereby attenuating the malignancy of OS cells. +other 32483433 hsa-mir-137 Colorectal Neoplasms Mechanistically, cAMP response element-binding protein (CREB1) transcriptionally upregulates ARHGAP5 expression, and decreased miR-137 further contributes to ARHGAP5 mRNA stability in CRC. +transcription factor target 32483426 hsa-mir-222 Ovarian Neoplasms 3p transcription and confirmed the tumor-suppressive function of miR +other 32483416 hsa-mir-215 Colitis Results: Oxidative stress repressed Dicer expression in inflamed colon tissues by inducing miR-215 expression. +lncRNA target 32483313 hsa-mir-149 Breast Neoplasms Finally, in vivo validation in an experimental metastasis model conformed an inhibitory action of propofol against experimental lung metastasis and the essential mechanistic role of miR5p/IL-6 loop. +circulation_biomarker_diagnosis_up 32483145 hsa-mir-130b Medulloblastoma Exosomes from MB patient plasma could transfer miR-130b-3p to an MB cell line and played suppressor roles for cell proliferation. +transcription factor target 32483111 hsa-mir-340 Adenocarcinoma of Lung 5p/PNO1/Notch axis might be a potential target for individualized and precise treatment of LUAD patients in the future. +genetics_overexpression_promote 32482375 hsa-mir-9 Carcinoma, Renal Cell Overexpression of miR +other 32482362 hsa-mir-483 Atrial Fibrillation 5p can be potential biomarkers of the baseline and 24-month periods, respectively. +circulation_biomarker_diagnosis_ns 32482255 hsa-mir-23a Endometriosis Plasma samples from another cohort of women with surgically confirmed endometriosis (n = 53) and disease-free control women (n = 53) were checked for hemolysis using spectrophotometry and the ratio of miR-23a and miR-451 by means of qRT-PCR. +circulation_biomarker_diagnosis_ns 32482255 hsa-mir-451 Endometriosis Plasma samples from another cohort of women with surgically confirmed endometriosis (n = 53) and disease-free control women (n = 53) were checked for hemolysis using spectrophotometry and the ratio of miR-23a and miR-451 by means of qRT-PCR. +lncRNA target 32481626 hsa-mir-675 Colorectal Neoplasms 5p as a new therapeutic target for the treatment of colorectal cancer. +circulation_biomarker_diagnosis_down 32481405 hsa-mir-206 Pre-Eclampsia To study the correlation between circulating microRNA-206 (miR-206) levels and endothelin-1 (ET-1) levels, and to explore its association with preeclampsia (PE) risk.Reverse transcription-PCR (RT-PCT) was used to compare the plasma miR-206 levels in 200 PE patients and 200 healthy controls. The expression level of ET-1 was significantly decreased in human umbilical vein endothelial cells cells transfected with miR-206.miR-206 can down-regulate the expression of EDN1 gene, which may be related to the increased risk of preeclampsia. +other 32481402 hsa-mir-21 Lung Neoplasms BACKGROUND: Previous studies have reported that microRNA 21 (mRNA 21) has involved in the procedure of lung cancer (LC). +other 32481368 hsa-mir-141 Prostatic Neoplasms CONCLUSION: This meta-analysis suggests that miR-141 has a high diagnostic value for prostate cancer. +other 32481361 hsa-mir-146a Sepsis CONCLUSION: MiR-146b presents superior potential as a prognostic biomarker in sepsis patients compared to MiR-146a, which implies the clinical application of miR-146b in disease management of sepsis. +other 32481361 hsa-mir-146b Sepsis CONCLUSION: MiR-146b presents superior potential as a prognostic biomarker in sepsis patients compared to MiR-146a, which implies the clinical application of miR-146b in disease management of sepsis. +lncRNA target 32481356 hsa-mir-93 Prostatic Neoplasms These fndings suggest miR-93 may serve as a novel target for prostate cancer prognosis and therapy. +genetics_knock down_suppress 32481242 hsa-mir-204 Osteoarthritis The knockdown of miR-204 may provide new approaches for clinical treatment of OA. +other 32480291 hsa-mir-148a Precursor Cell Lymphoblastic Leukemia-Lymphoma A slight insignificant decrease in IL-17 in ALL patients was observed.ALL patients showed a significant increase in miR-21 (p < 0.05), miR-148a (p < 0.01), miR-24 (p < 0.05) and a significant reduction in miR-155 (p < 0.01). +other 32480291 hsa-mir-24 Precursor Cell Lymphoblastic Leukemia-Lymphoma A slight insignificant decrease in IL-17 in ALL patients was observed.ALL patients showed a significant increase in miR-21 (p < 0.05), miR-148a (p < 0.01), miR-24 (p < 0.05) and a significant reduction in miR-155 (p < 0.01). +other 32480291 hsa-mir-155 Precursor Cell Lymphoblastic Leukemia-Lymphoma A slight insignificant decrease in IL-17 in ALL patients was observed.ALL patients showed a significant increase in miR-21 (p < 0.05), miR-148a (p < 0.01), miR-24 (p < 0.05) and a significant reduction in miR-155 (p < 0.01). +other 32480291 hsa-mir-21 Precursor Cell Lymphoblastic Leukemia-Lymphoma A slight insignificant decrease in IL-17 in ALL patients was observed.ALL patients showed a significant increase in miR-21 (p < 0.05), miR-148a (p < 0.01), miR-24 (p < 0.05) and a significant reduction in miR-155 (p < 0.01). +transcription factor target 32478824 hsa-mir-658 Colorectal Neoplasms Then, RT-qPCR results indicated that miR-3658 expression is decreased in colorectal cancer (CRC) tumor tissues, compared with normal pairs. Overall, these findings demonstrated that miR-3658 as a tumor suppressor miRNA exerts its effect against OCT4 gene expression, and it has the potential of being used as a prognostic marker and therapeutic target against colorectal cancer. +transcription factor target 32478716 hsa-mir-145 Endometrial Hyperplasia We confirmed the attenuation of intimal hyperplasia of vein grafts by transducing miR-145 before implantation surgery through the phenotype change of the VSMCs. +transcription factor target 32478689 hsa-mir-223 Atrial Fibrillation On the other hand, miR3p functioned in AF by targeting PAX6, which was associated with the regulation of apoptosis in AF. +other 32478495 hsa-mir-455 Breast Neoplasms miR-455 may play an important role in lymph node metastasis of BC by interacting with MALAT1. +circulation_biomarker_diagnosis_up 32478410 hsa-mir-451a Dermatitis, Atopic miR-451a is uniquely expressed in different blood compartments of patients with AD and may serve as a promising novel biomarker for the early diagnosis of AD. +other 32478340 hsa-mir-24 Porcine Reproductive and Respiratory Syndrome Accordingly, we could use this fluorescent nucleotide for the detection of microRNA 24-3P, a biomarker of porcine reproductive and respiratory syndrome virus. +other 32478334 hsa-mir-17 Lymphoma Using both classic (phenformin) and newly developed (IM156) biguanides, we demonstrate that elevated miR-17 approximately 92 expression in Myc(+) lymphoma cells promotes increased apoptosis to biguanide treatment in vitro and in vivo. +lncRNA target 32478168 hsa-mir-149 Carcinoma, Non-Small-Cell Lung Inhibition of miR-149 reverses the promotion effect of HDACis on cisplatin-induced DNA damage and cell apoptosis in ERCC1-high NSCLC cells. In conclusion, this study reveals a novel mechanism by which HDACis re-sensitizes ERCC1-high NSCLC cells to cisplatin via regulation of the E2F1/miR-149/ERCC1 axis, and we propose that combination of HDACis and cisplatin might hold promise to be a more effective therapeutic paradigm for ERCC1-high NSCLCs. +transcription factor target 32478123 hsa-mir-4281 Myocarditis The predicted target genes of miR3p and miR-4281 are involved in several pathways, mainly inflammatory and cardiac injury response. +circulation_biomarker_diagnosis_up 32478123 hsa-mir-4763 Myocarditis This study provides a global profile of circulating miRNAs in patients with FM, among which miR +genetics_GWAS 32478079 hsa-mir-23 Thyroid Cancer, Papillary Plasma miR-323 was significantly increased in PTC patients with BRAF V600E mutation when compared to those with wild-type BRAF. +other 32478052 hsa-let-7i Disease Our data showed that let-7i-5p performs a multi-functional role in distinct signaling transduction pathways involved in cell morphology and cell migration in both normal and pathogenic fibroblasts. +lncRNA target 32478052 hsa-let-7i Urethral Stricture We conclude that let-7i-5p plays an essential role in regulating cell shape and tissue elasticity, cell migration, cell morphology and cytoskeleton, and could serve as a potential target for clinical treatment of urethral stricture patients. +circulation_biomarker_diagnosis_up 32477329 hsa-mir-122 Brain Ischemia MicroRNA sequencing analysis revealed that brain ischemia significantly altered miRNA expression profiles in circulating NK cells, in which miRNA-451a and miRNA5p were dramatically upregulated. +circulation_biomarker_diagnosis_up 32477329 hsa-mir-451a Brain Ischemia MicroRNA sequencing analysis revealed that brain ischemia significantly altered miRNA expression profiles in circulating NK cells, in which miRNA-451a and miRNA5p were dramatically upregulated. +genetics_overexpression_suppress 32477065 hsa-mir-224 Diabetes Mellitus, Type 2 In brain tissues of T2DM with OSA, MALAT1 and NLRP3 were overexpressed, while miR +genetics_overexpression_suppress 32477065 hsa-mir-224 Sleep Apnea, Obstructive In brain tissues of T2DM with OSA, MALAT1 and NLRP3 were overexpressed, while miR +other 32476991 hsa-mir-106b Myocardial Infarction METHODOLOGY: We used bioinformatics' analysis to identify RNAs linked to ubiquitin system and specific to AMI, named, (lncRNA-RP11-175K6.1), (LOC101927740), microRNA-106b-5p (miR-106b-5p) and Anaphase, promoting complex 11 (ANapc11mRNA). RESULTS: Our study revealed a significant decrease in both lncRNA-RP11-175K6.1 and ANapc11mRNA expression of in the sera samples of AMI patients compared to that of the two control groups alongside with significant upregulation of miR-106b-5p. +circRNA target 32476580 hsa-mir-373 Osteoarthritis In the present study, the expression levels of circRNA-UBE2G1 and HIF-1a were significantly increased in OA tissues, whereas miR373 expression was downregulated. Collectively, our data suggest that circRNA-UBE2G1 facilitates the progression in the LPS-induced OA cell model via regulating the miR373/HIF-1a axis. +genetics_overexpression_promote 32476275 hsa-mir-26b Adenocarcinoma of Lung miR-26b-5p overexpression and X-irradiation led to enhanced radiosensitivity of LUAD cells. +genetics_knock down_promote 32475133 hsa-mir-129 Fibrosis, Renal Downregulation of miR-129 reversed inhibition of renal fibrosis induced by NEAT1 silencing, and upregulation of collagen type I also reversed inhibition of renal fibrosis caused by miR-129 overexpression. +genetics_knock down_promote 32474761 hsa-mir-490 Myocardial Infarction 3p would affect autophagy, apoptosis, and IR injury, we evaluated apoptosis, autophagy, and infarct size via gain- and loss-of-function experiments. +genetics_knock down_promote 32474761 hsa-mir-490 Microvascular Obstruction 3p would affect autophagy, apoptosis, and IR injury, we evaluated apoptosis, autophagy, and infarct size via gain- and loss-of-function experiments. +circulation_biomarker_diagnosis_up 32474742 hsa-mir-212 Alzheimer Disease RESULTS: The level of miR-212 was apparently down-regulated, and the level of PDCD4 was significantly up-regulated in plasma from AD patients and Abeta(25-35)-treated SH-SY5Y and IMR-32 cells. +lncRNA target 32474464 hsa-mir-204 Uterine Cervical Neoplasms Moreover, transcription factor AP-2 alpha (TFAP2A) was screened to be the most affected target gene by miR +other 32474365 hsa-mir-203 Melanoma Differential expression analysis revealed miRNA significantly downregulated in metastatic tumors, including miR-205, miR-203, miR-200a-c, and miR-141. Furthermore, sequential feature selection and classification analysis identified miR-205 and miR-203 as the miRNA best able to discriminate between primary and metastatic tumors. +other 32474365 hsa-mir-205 Melanoma Differential expression analysis revealed miRNA significantly downregulated in metastatic tumors, including miR-205, miR-203, miR-200a-c, and miR-141. Furthermore, sequential feature selection and classification analysis identified miR-205 and miR-203 as the miRNA best able to discriminate between primary and metastatic tumors. +circulation_biomarker_diagnosis_ns 32473920 hsa-mir-93 Duane Retraction Syndrome lncRNA MEG3 and Nrf2 were decreased and miR-93 was increased in blood samples of DR patients and HG-treated human RPE and ARPE-19 cells. +circRNA target 32473899 hsa-mir-30 Colorectal Neoplasms CONCLUSION: Silencing of circ-FARSA restricted the growth of CRC through regulating the miR +transcription factor target 32473637 hsa-mir-125 Uterine Cervical Neoplasms CONCLUSION: In conclusion, the findings demonstrated that miR-125 inhibited cervical cancer progression and development by suppression VEGF and PI3K/AKT signaling pathway. +circulation_biomarker_prognosis_ns 32473385 hsa-mir-140 Lung Neoplasms Top five circulating miRNAs, including miR-92a, miR +circulation_biomarker_prognosis_ns 32473385 hsa-mir-92a Lung Neoplasms Top five circulating miRNAs, including miR-92a, miR +circulation_biomarker_prognosis_ns 32473385 hsa-mir-374a Lung Neoplasms Top five circulating miRNAs, including miR-92a, miR +circulation_biomarker_prognosis_ns 32473385 hsa-mir-223 Lung Neoplasms Top five circulating miRNAs, including miR-92a, miR +circulation_biomarker_prognosis_ns 32473385 hsa-mir-31 Lung Neoplasms Top five circulating miRNAs, including miR-92a, miR +genetics_overexpression_suppress 32473243 hsa-mir-182 Colonic Neoplasms 5p overexpression in colon cancer cells and human umbilical vein endothelial cells (HUVECs) downregulated VEGF-A as well as VEGF receptor (VEGFR)-2 and VEGFR-3, thereby inhibiting the phosphorylation of ERK and AKT. +genetics_overexpression_suppress 32473223 hsa-mir-20a Endometrial Neoplasms These results point to CAF-derived EVs carrying overexpressed miR-320a as a novel direction for therapeutic strategies for EC. +genetics_overexpression_suppress 32473153 hsa-mir-4262 Esophageal Squamous Cell Carcinoma Overexpression of miR-4262 reduced proliferative potential and enhanced apoptosis in esophageal cancer cells. +transcription factor target 32473103 hsa-mir-532 Plaque, Atherosclerotic 3p-CSF2RA axis dysregulation is a key driver in vulnerable plaque formation. +other 32472764 hsa-mir-184 Osteosarcoma Recent studies indicate that MEG3, a long non-coding RNA (lncRNA) and microRNA-184 (miR-184) are abnormally expressed in osteosarcoma (OS). Together these studies show that both MEG3 and miR-184 cooperatively regulate the proliferation, migration and apoptosis of OS. +genetics_overexpression_suppress 32472755 hsa-mir-139 Carcinoma, Squamous Cell Overexpression of miR +lncRNA target 32472715 hsa-mir-155 psoriasis 1 Thus, miR-155/GATA3/IL37 may be potent targets for psoriasis treatment, which needs further in vivo and clinical investigation. +other 32472396 hsa-mir-107 Alzheimer Disease The study confirmed that the miR-107 expression levels were dramatically decreased in patients with AD and in beta-amyloid (Abeta) (Abeta)-treated SH-SY5Y cells compared with control groups. +genetics_overexpression_promote 32472311 hsa-mir-424 Glioma The regulation of GAS5 on miR-424 expression was examined in GAS5-overexpressing glioma cells by combining methylation-specific PCR, western blotting, and RNA immunoprecipitation. +other 32472154 hsa-mir-486 Leukemia, Myeloid, Acute SOCS2-STAT3 proliferation axis is therefore involved in the pathogenesis of AML, providing a novel molecular mechanism and diagnostic and therapeutic clues for AML. +lncRNA target 32472129 hsa-mir-320d Astrocytoma We identified the lowly expressed miR-320d in SEGA as a potential regulator of MMPs, which can decrease MMP2 expression in human fetal astrocyte cultures. This study provides evidence of a dysregulated MMP/TIMP proteolytic system in SEGA of which MMP2 could be rescued by microRNA-320d. +lncRNA target 32472129 hsa-mir-320d Tuberous Sclerosis 1 We identified the lowly expressed miR-320d in SEGA as a potential regulator of MMPs, which can decrease MMP2 expression in human fetal astrocyte cultures. This study provides evidence of a dysregulated MMP/TIMP proteolytic system in SEGA of which MMP2 could be rescued by microRNA-320d. +genetics_knock down_promote 32471743 hsa-mir-200a Gingival Overgrowth To confirm the significance of miR-200a and ZEB2 in the CsA-induced gingival overgrowth, miR-200a inhibitor and shRNA mediated knockdown of ZEB2 were used and cell proliferation in HGFs was assessed by MTT assay. CONCLUSION: Our results showed that insufficient miR-200a in HGFs caused by CsA administration may lead to gingival enlargement mediated by the upregulation of ZEB2. +genetics_overexpression_promote 32471413 hsa-mir-449b Adenocarcinoma of Lung MiR-449b-5p was predicted to target PSMG3-AS1, and overexpression of miR-449b-5p resulted in the downregulation of PSMG3-AS1 in LUAD cells. +other 32471285 hsa-mir-125b Urinary Bladder Neoplasms The present findings suggested a diagnostic potential of miR-125b, -145, -183, and -221 in combination with VUC for non-invasive detection of BCa in urine. +transcription factor target 32470970 hsa-mir-9 Hypoxia-Ischemia, Brain The expression of miRNA-9 was detected by RT-PCR analyses, and the results shown that miRNA-9 was significantly increased in the hippocampus of neonatal rats following HIBD and in the PC12 cells following hypoxic-ischemic injury, while FA and LNA-miR-9 both inhibited the expression of miRNA-9, suggesting that the therapeutic effect of FA was mainly attributed to the inhibition of miRNA-9 expression. Therefore, our findings indicate that FA treatment may protect against neuronal death through the inhibition of miRNA-9 induction in the rat hippocampus following hypoxic-ischemic damage. +lncRNA target 32470877 hsa-mir-223 Parkinson Disease Overall, our finding illuminates that GAS5 accelerates PD progression through targeting miR3p/NLRP3 axis. +lncRNA target 32470454 hsa-mir-122 Acute Lung Injury 5p protected against acute lung injury via regulation of DUSP4/ERK signaling in pulmonary microvascular endothelial cells. +genetics_overexpression_promote 32470449 hsa-mir-542 Fibrosis, Renal Functional experiments revealed that overexpression of miR +other 32470448 hsa-mir-148b Angelman Syndrome KEY FINDINGS: The levels of MIAT and PAPPA were augmented, whereas mature miR-148b level was repressed in ox-LDL-induced AS model. SIGNIFICANCE: Proliferation and migration were modified by MIAT/miR-148b/PAPPA axis in ox-LDL induced AS cell model, supplying a novel insight into the underlying application of MIAT in the clinical treatment of AS. +exosome 32470446 hsa-mir-125b Pancreatic Carcinoma The tumor suppressor STARD13 was directly targeted by miR-125b-5p in pancreatic cancer, which was associated with good prognosis and was suppressed by exosomes derived from highly invasive cancer cells. +genetics_overexpression_promote 32469461 hsa-mir-146a Squamous Cell Carcinoma of Head and Neck OSCC cell lines that overexpressed miR-146a displayed higher proliferation, colony formation, invasion, and MMP-2 activity than cells transfected with a control vector. +circulation_biomarker_diagnosis_ns 32469233 hsa-mir-29a Gluteal Muscle Contracture Collectively, miR-29a was notably depressed and regulated cell viability and fibrosis by directly targeting HSP47 in GMC, which suggest that circulating miR-29a might be a potential biomarker for early diagnosis and provides a novel therapeutic target for GMC. +genetics_overexpression_promote 32469170 hsa-mir-98 Hepatitis B, Chronic Overexpression of miR +transcription factor target 32469167 hsa-mir-122a Laryngeal Neoplasms miR-122a and miR-3195 may act as tumor suppressors and play a role in LC pathogenesis. +transcription factor target 32469167 hsa-mir-195 Laryngeal Neoplasms miR-122a and miR-3195 may act as tumor suppressors and play a role in LC pathogenesis. +other 32469162 hsa-mir-126a Aortic Aneurysm, Abdominal In summary, our work demonstrates that miR-126a-5p limits experimental AAA formation and reduces ADAMTS-4 expression in abdominal aortas. +transcription factor target 32469097 hsa-mir-196b Tuberous Sclerosis Tuberous sclerosis 1 (Tsc1) and transforming growth factor-beta receptor 1 (TGFBR1) were demonstrated to be the direct target genes of miR-196b-5p. +lncRNA target 32469064 hsa-mir-4429 Uterine Cervical Neoplasms To sum up, these results suggested the potential mechanism of NR2F2-AS1 in cervical cancer and revealed that NR2F2-AS1 exerted its carcinogenic effect via regulating miR-4429/MBD1 axis, indicating a promising insight into the therapeutic target of cervical cancer. +target gene 32469047 hsa-mir-135a Colorectal Neoplasms Long intergenic non-coding RNA LINC00662 contributes to malignant growth of colorectal cancer cells by upregulating c-myc via sponging microRNA-145. +genetics_overexpression_promote 32468302 hsa-mir-21 Electrocardiography, Ambulatory More precisely, mir-21 overexpression in tissues promotes atrium fibrosis and impairs conductibility. +genetics_overexpression_promote 32468302 hsa-mir-21 Atrial Fibrillation More precisely, mir-21 overexpression in tissues promotes atrium fibrosis and impairs conductibility. +other 32468257 hsa-mir-27a Prostatic Neoplasms This investigation aimed to evaluate associations between the hsa-miR-27a (rs895819 T > C) and hsa-miR-125a (rs12976445 C > T) gene variations and the risk of PCa. Our findings indicated that the hsa-miR-27a and hsa-miR-125a gene variations are not increased PCa predisposition in the Iranian population. +other 32468257 hsa-mir-125a Prostatic Neoplasms This investigation aimed to evaluate associations between the hsa-miR-27a (rs895819 T > C) and hsa-miR-125a (rs12976445 C > T) gene variations and the risk of PCa. Our findings indicated that the hsa-miR-27a and hsa-miR-125a gene variations are not increased PCa predisposition in the Iranian population. +lncRNA target 32468237 hsa-mir-1 Esophageal Neoplasms 3p level and inhibition of CORO1C/TPM3 activity. +other 32468186 hsa-mir-375 Heart Septal Defects, Ventricular In our previous study of fetuses with ventricular septal defects, we discovered that microRNA-375 (miR-375) is obviously upregulated compared with that in healthy controls. +other 32468186 hsa-mir-375 Pericardial Effusion Disruption of miR-375 led to a decreased heart rate, pericardial edema, and abnormal cardiac looping. +other 32468068 hsa-mir-20 Reinjuries In addition, reverse transcriptionquantitative PCR, western blotting and dualluciferase reporter assay experiments were performed to determine the relationship between MPC, miR3203p and Akt3, and their effects on H/R injury. Moreover, MPC partially reversed the increase in miR3203p expression and the decrease in Akt3 levels caused by H/R injury. +lncRNA target 32468068 hsa-mir-20 Anodontia The current findings revealed that MPC could protect cardiomyocytes from H/R damage through targeting miR3203p to regulate the PI3K/Akt3 signaling pathway. +genetics_knock down_promote 32468065 hsa-mir-142 Stomach Neoplasms NNTAS1 and SOX4 were upregulated, whereas miR1425p was downregulated in GC tissues and cells compared with normal tissues and cells. Collectively, the present study indicated that NNTAS1 knockdown decreased GC cell proliferation, migration and invasion, and induced GC cell apoptosis by regulating the miR1425p/SOX4/Wnt/betacatenin signaling pathway axis. +genetics_knock down_promote 32468055 hsa-mir-203a Liver Neoplasms In conclusion, MIAT knockdown potentiated the therapeutic effect of TAE in liver cancer by regulating the miR203a/HIF1alpha axis in vitro and in vivo, thus expanding our understanding on the function and molecular basis of MIAT in TAE treatment for liver cancer. +lncRNA target 32468054 hsa-mir-340 Reperfusion Injury In conclusion, the findings of the present study suggested that miR3405p may protect PC12 cells against OGD/R through targeting Neurod4, which could provide important implications for the treatment of ischemiareperfusion injury based on miR3405p expression levels in vivo. +circulation_biomarker_diagnosis_ns 32468054 hsa-mir-340 Ischemic Stroke The expression levels of microRNA (miR)3405p are reportedly decreased in the peripheral blood during acute ischemic stroke; however, the direct effect and mechanism of action of miR3405p in ischemic stroke remains largely unknown. +lncRNA target 32468045 hsa-mir-199a Premature Birth The aim of the present study was to determine the effect and underlying mechanism of microRNA (miR)199a3p/highmobility group box 1 protein (HMGB1) signaling in cervical epithelial inflammation in PTB. These results indicate that miR199a3p acts as a negative inflammatory regulator in PTB by targeting HMGB1 to regulate the TLR4/NFkappaB pathway. +other 32468044 hsa-mir-335 Osteitis The results of the present study not only provided new insights into the regulatory effects of miR3355p on osteogenic differentiation in an inflammatory microenvironment, but may also promote the development of potential therapeutic strategies for the treatment of bonerelated inflammatory diseases. +lncRNA target 32468043 hsa-mir-21 Carcinoma, Non-Small-Cell Lung Taken together, these findings demonstrated that propofol inhibited the viability and promoted the apoptosis of NSCLC cells by downregulating the miR215p/MAPK10 axis. +lncRNA target 32468034 hsa-mir-93 Acute Lung Injury Taken together, the findings of the present study indicate that miR93 attenutes LPSinduced lung injury by regulating the TLR4/MyD88/NFkappaB signaling pathway, suggesting that miR93 may prove to be a potential therapeutic target for ALI. +other 32468029 hsa-mir-29a Central Nervous System Diseases In conclusion, the findings of the present study identified a potential mechanism of action for miR29a in NSPC differentiation and provided a novel insight into the treatment strategies for CNS damage. +genetics_overexpression_promote 32468021 hsa-mir-497 Esophageal Squamous Cell Carcinoma Following irradiation, transfection with miR4975p mimics reduced the promoting effect of LINC00473 overexpression on ESCC cell proliferation, and partially impeded the resistance of ESCC cells to Xray radiation induced by LINC00473 overexpression. +genetics_knock down_promote 32467999 hsa-mir-103a salivary gland adenoid cystic carcinoma TPD52 overexpression rescued the effect of miR103a3p on promoting SACC cell migration, suggesting that miR103a3p acted as an oncogene to promote cancer metastasis by directly targeting TPD52. +genetics_overexpression_promote 32467998 hsa-mir-205 Colonic Neoplasms It was identified that MDM4 was overexpressed in colon cancer tissues and cells, and that there was a negative correlation between miR205 and MDM4 expression in colon cancer. +genetics_overexpression_promote 32467987 hsa-mir-369 Carcinoma, Non-Small-Cell Lung Also, the overexpression of miR369 activated the mitogenactivated protein kinase signaling pathway by interacting with NF1, consequently potentiating LUSC cell growth. +transcription factor target 32467986 hsa-mir-29a Lupus Erythematosus, Systemic miR29a inhibitors and mimics were transfected into PBMCs obtained from HCs and patients with SLE, and an ELISA was used to demonstrate that miR29a inhibition increased the production of IgG. +lncRNA target 32467714 hsa-mir-155 Inflammation AE and metformin can attenuate endothelial inflammation through regulating miR-146a and miR-155. +lncRNA target 32467714 hsa-mir-146a Inflammation AE and metformin can attenuate endothelial inflammation through regulating miR-146a and miR-155. +genetics_knock down_suppress 32467667 hsa-mir-515 Stomach Neoplasms Silencing of miR5p or overexpression of HIF-1alpha could evidently rescue the attenuated aggressive phenotype of GC cells caused by circ-MAT2B knockdown. +transcription factor target 32467578 hsa-mir-451 Fibrosis We found that EphB2 upregulation is a direct downstream molecular event of decreased expression of miR-451 and miR-185 in the process of liver fibrosis. These findings indicate that miR-451 and miR-451/XPO-1/miR-185 axis play important and synergistic regulatory roles in hepatic fibrosis partly through co-targeting EphB2, which provides a novel therapeutic strategy for the treatment of hepatic fibrosis. +transcription factor target 32467578 hsa-mir-185 Fibrosis We found that EphB2 upregulation is a direct downstream molecular event of decreased expression of miR-451 and miR-185 in the process of liver fibrosis. These findings indicate that miR-451 and miR-451/XPO-1/miR-185 axis play important and synergistic regulatory roles in hepatic fibrosis partly through co-targeting EphB2, which provides a novel therapeutic strategy for the treatment of hepatic fibrosis. +target gene 32467565 hsa-mir-122 Carcinoma, Hepatocellular lncRNA-SOX2OT promotes hepatocellular carcinoma invasion and metastasis through miR-122-5p-mediated activation of PKM2. +transcription factor target 32467560 hsa-mir-423 Intervertebral Disc Degeneration CONCLUSIONS miR5p and NLRX1 could be potential therapeutic targets for patients with disc degeneration. +other 32466856 hsa-mir-17 Carcinoma, Non-Small-Cell Lung CONCLUSION: The miR92 gene cluster can likely serve as a diagnostic marker in NSCLC. +lncRNA target 32466797 hsa-mir-125b Melanoma We also showed that LICN00520 promotes the growth and metastasis of melanoma in vivo through regulating miR-125b-5p/EIF5A2 axis. +target gene 32466537 hsa-mir-204 Triple Negative Breast Neoplasms HOX Transcript Antisense RNA HOTAIR Abrogates Vasculogenic Mimicry by Targeting the AngiomiR-204/FAK Axis in Triple Negative Breast Cancer Cells. +genetics_knock down_promote 32466450 hsa-mir-125b-1 Hypercholesterolemia 3p by IPre, which seems to be associated with the loss of cardioprotection. +transcription factor target 32466437 hsa-mir-690 Inflammation In conclusion, miR-690 plays a protective function and could be a useful target to reduce obesity. +transcription factor target 32466159 hsa-mir-485 Osteoarthritis We detail how visfatin affected VEGF expression and EPC angiogenesis in OASFs by inhibiting miR5p synthesis through the PI3K and Akt signaling pathways. +lncRNA target 32464601 hsa-mir-1827 Carcinoma, Hepatocellular In addition, our results show that miR-1827 is a binding target of hsa_circ_0003141, and indicate that hsa_circ_0003141 regulates UBAP2 expression by sponging miR-1827 in HCC cells. Together, our results indicate that hsa_circ_0003141 functions as an oncogene in HCC cells, and suggest that the hsa_circ_0003141/miR-1827/UBAP2 axis might represent a novel therapeutic option for the treatment of HCC. +lncRNA target 32464547 hsa-mir-26a Myocardial Infarction Taken together, these results suggested that MIRF contributed to cardiomyocyte apoptosis through modulating Bak1 by regulation of miR-26a, which can be a potential therapeutic target for the treatment of ischemic heart disease. +transcription factor target 32464547 hsa-mir-26a Coronary Artery Disease Taken together, these results suggested that MIRF contributed to cardiomyocyte apoptosis through modulating Bak1 by regulation of miR-26a, which can be a potential therapeutic target for the treatment of ischemic heart disease. +lncRNA target 32464547 hsa-mir-26a Myocardial Ischemia We found that long noncoding RNA (lncRNA) myocardial infarction-regulatory factor (MIRF) promoted ischemic myocardial injury by regulating autophagy through targeting miR-26a. +other 32464547 hsa-mir-26a Heart Injuries Moreover, forced expression of miR-26a protected against MI-induced cardiac injury and attenuated cardiac apoptosis. +circRNA target 32464246 hsa-mir-130a Carcinoma, Renal Cell Then we predicted the underlyingly upstream modulator of miR-130a-3p was a novel circRNA hsa_circ_0054537, which exhibited dysregulated in RCC cells. +exosome 32464126 hsa-mir-532 Intervertebral Disc Degeneration Overall, these data indicate that exosomes from BMSCs may suppress TNF-alpha-induced apoptosis, ECM degradation, and fibrosis deposition in NPCs through the delivery of miR5p via targeting RASSF5. +genetics_overexpression_promote 32463958 hsa-mir-204 Mouth Neoplasms 5p overexpression suppressed oral cancer cell aggressiveness. +genetics_knock down_suppress 32463882 hsa-mir-493 Optic atrophy 1 and deafness More importantly, knockdown of miR +other 32463795 hsa-mir-378a Reperfusion Injury As such, this study evaluated the protective effects and underlying mechanisms of action of miR-378a-3p on H9C2 cardiomyocyte apoptosis following I/R injury. +other 32463795 hsa-mir-378a Coronary Artery Disease Increasing evidence indicates that miR-378a-3p might provide a potential cardioprotective effect against ischemic heart disease. +other 32463793 hsa-mir-6089 Coronary Artery Disease Furthermore, we showed that miR-6089 was downregulated in atherosclerotic coronary tissues compared to normal coronary artery samples. There was a negative association between expression of HIX003209 and miR-6089 in atherosclerotic coronary tissues. +lncRNA target 32463728 hsa-mir-296 Renal Insufficiency Immunoreactivity of the mitochondrial biogenesis marker peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1alpha and expression of the mitochondria-associated microRNAs miR-15a, miR-181a, miR-196a, and miR3p, which target several mtDNA genes, were higher in RAS-STCs compared with normal STCs, suggesting a potential modulation of mitochondria-related gene expression. +lncRNA target 32463728 hsa-mir-181a Renal Insufficiency Immunoreactivity of the mitochondrial biogenesis marker peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1alpha and expression of the mitochondria-associated microRNAs miR-15a, miR-181a, miR-196a, and miR3p, which target several mtDNA genes, were higher in RAS-STCs compared with normal STCs, suggesting a potential modulation of mitochondria-related gene expression. +lncRNA target 32463728 hsa-mir-196a Renal Insufficiency Immunoreactivity of the mitochondrial biogenesis marker peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1alpha and expression of the mitochondria-associated microRNAs miR-15a, miR-181a, miR-196a, and miR3p, which target several mtDNA genes, were higher in RAS-STCs compared with normal STCs, suggesting a potential modulation of mitochondria-related gene expression. +other 32463418 hsa-mir-6931 Bone Diseases In conclusion, for the first time, we report the role of cicr_1983-miRGas7 ceRNA-interaction in C(2)S-induced osteogenic differentiation of MSCs and bone defect healing. +genetics_overexpression_promote 32463333 hsa-mir-382 Pancreatic Carcinoma Overexpression of miR-382 or downregulation of Anxa3 was shown to inhibit colony formation, migration, and invasion abilities of PC cells. +genetics_overexpression_promote 32462982 hsa-mir-133 Triple Negative Breast Neoplasms Consistent with the decreased expression of YES Proto-Oncogene 1, overexpression of miR-133 suppressed the phosphorylation of YAP1 in triple-negative breast cancer cells. +circRNA target 32462972 hsa-mir-1285 Breast Neoplasms A novel circular RNA, hsa_circ_0000376, was identified in breast cancer that may act as a sponge targeting miR3p expression which through its target genes, SMURF1, BTRC, and TP53, may further regulate tumorigenesis. +genetics_overexpression_promote 32462956 hsa-mir-195 Squamous Cell Carcinoma of Head and Neck Silencing LINC00520 or overexpressing miR-195 promoted radiosensitivity and inhibited cell proliferation, invasion, migration, and apoptosis in HNSCC. +other 32462952 hsa-mir-140 Pulmonary Fibrosis 5p expression; blocked the expressions of TG2, Wnt-1, and beta-catenin; and decreased p-Smad2, p-Smad3, CTGF, MMP-9, and TGF-beta1 expressions. +genetics_knock down_promote 32462698 hsa-mir-29 Carcinoma, Hepatocellular 3p inhibitor neutralized the repressing effects of TMPO-AS1 knockdown on HCC development. +transcription factor target 32462552 hsa-mir-615 Spinal Cord Injuries This work thus uncovers miR-615 as an effective miRNA that regulates LINGO-1 in NSC and SCI animals, and suggests miR-615 as a potential therapeutic target for traumatic central nervous system (CNS) injury. +genetics_knock down_promote 32462038 hsa-mir-217 Carcinoma, Hepatocellular Additionally, a HOTAIR knockdown could increase the sensitivity of sorafenib for HCC treatment by up-regulating miR-217. +other 32462034 hsa-mir-141 Prostatic Hyperplasia 5p) miRNAs discriminated between BPH and areas of cancer-bearing prostate tissue harboring different numbers of cancer cells (PCa 15-70%, PCa 2-10%, and PCA 0%, respectively), with an area under the receiver operating characteristics curve (AUC-ROC) > 0.9. +other 32462034 hsa-mir-615 Prostatic Hyperplasia 5p) miRNAs discriminated between BPH and areas of cancer-bearing prostate tissue harboring different numbers of cancer cells (PCa 15-70%, PCa 2-10%, and PCA 0%, respectively), with an area under the receiver operating characteristics curve (AUC-ROC) > 0.9. +other 32462034 hsa-mir-141 Atrial Premature Complexes 5p) miRNAs discriminated between BPH and areas of cancer-bearing prostate tissue harboring different numbers of cancer cells (PCa 15-70%, PCa 2-10%, and PCA 0%, respectively), with an area under the receiver operating characteristics curve (AUC-ROC) > 0.9. +other 32462034 hsa-mir-2 Freeman-Sheldon syndrome Only miRNA 32-5p discriminated BPH specimens from sections of cancer-bearing prostate tissue with a low percentage, a high percentage, or no dysplastic cells. +other 32462034 hsa-mir-615 Atrial Premature Complexes 5p) miRNAs discriminated between BPH and areas of cancer-bearing prostate tissue harboring different numbers of cancer cells (PCa 15-70%, PCa 2-10%, and PCA 0%, respectively), with an area under the receiver operating characteristics curve (AUC-ROC) > 0.9. +other 32462034 hsa-mir-2 Atrial Premature Complexes 5p) miRNAs discriminated between BPH and areas of cancer-bearing prostate tissue harboring different numbers of cancer cells (PCa 15-70%, PCa 2-10%, and PCA 0%, respectively), with an area under the receiver operating characteristics curve (AUC-ROC) > 0.9. +other 32462034 hsa-mir-2 Prostatic Hyperplasia 5p could be considered as potential diagnostic biomarker discriminating BPH from noncancerous areas within cancer-bearing prostate tissue. +transcription factor target 32461997 hsa-mir-124 Neurotoxicity Syndromes We exposed rats to a La environment then observed the rats' learning and memory damage and neurotoxicity and the relationship with miR-124. CONCLUSION: La causes neurotoxicity by upregulating miR-124 expression and targeting PIK3CA through the PI3K/Akt signaling pathway. +genetics_overexpression_promote 32461938 hsa-mir-29c Glioma miR-29c is lowly expressed in glioma, and the overexpression of which in glioma cells can inhibit tumor cells proliferation and promote apoptosis. +target gene 32461380 hsa-mir-149 Carcinoma, Hepatocellular LncRNA NEAT1 modulates sorafenib resistance in hepatocellular carcinoma through regulating the miR-149-5p/AKT1 axis. +lncRNA target 32461319 hsa-mir-466d Encephalitis, Japanese Transfection with miRNA 466d-3p (miR-466d-3p) decreased interleukin-1beta (IL-1beta) expression and inhibited JEV replication in NA cells. +other 32461319 hsa-mir-466d West Nile Fever The NS3 proteins of Zika virus, West Nile virus, and dengue virus serotype 1 (DENV-1) and DENV-2 also decreased miR-466d-3p expression. +other 32461319 hsa-mir-466d Zika Virus Infection The NS3 proteins of Zika virus, West Nile virus, and dengue virus serotype 1 (DENV-1) and DENV-2 also decreased miR-466d-3p expression. +other 32461319 hsa-mir-466d Dengue The NS3 proteins of Zika virus, West Nile virus, and dengue virus serotype 1 (DENV-1) and DENV-2 also decreased miR-466d-3p expression. +circRNA target 32460831 hsa-mir-30 Urinary Bladder Neoplasms 5p /MTGR1/Notch pathway axis, which in turn may provide potential biomarkers and a therapeutic target for the management of bladder cancer. +circRNA target 32460831 hsa-mir-155 Urinary Bladder Neoplasms 5p /MTGR1/Notch pathway axis, which in turn may provide potential biomarkers and a therapeutic target for the management of bladder cancer. +transcription factor target 32460520 hsa-mir-215 Colonic Neoplasms This study investigated whether dysregulated miR-215 and XIAP play important roles in colon cancer cell apoptosis and the incidence of colon cancer. Results: Compared with the adjacent tissues, the expression of miR-215 in colon cancer tissue was significantly lower, whereas the expression of XIAP in colon cancer tissue was significantly higher. +circulation_biomarker_diagnosis_ns 32460356 hsa-mir-142 Brain Injuries, Traumatic Therefore, we characterized miR142 and miR155 expression in the perilesional cortex and plasma of rats that underwent lateral fluid-percussion injury, a model for TBI and in the human perilesional cortex post-TBI. +circulation_biomarker_diagnosis_ns 32460356 hsa-mir-155 Brain Injuries, Traumatic Therefore, we characterized miR142 and miR155 expression in the perilesional cortex and plasma of rats that underwent lateral fluid-percussion injury, a model for TBI and in the human perilesional cortex post-TBI. +other 32460303 hsa-mir-125a Rhinitis, Allergic The co-expressed DEGs of BPIFA1, CCL26, CPA3, and CST1, together with corresponding predicted miRNAs (e.g., miR5p and miR-125a-3p) were found to be significantly correlated with rhinitis and asthma. +other 32460303 hsa-mir-125a Asthma The co-expressed DEGs of BPIFA1, CCL26, CPA3, and CST1, together with corresponding predicted miRNAs (e.g., miR5p and miR-125a-3p) were found to be significantly correlated with rhinitis and asthma. +lncRNA target 32460193 hsa-mir-876 Uterine Cervical Neoplasms Moreover, tyrosine-protein kinase MET (c-MET) was identified to be a down-streaming target gene of miR +lncRNA target 32460190 hsa-mir-137 Osteosarcoma Our analyses indicated and helped to determine the role of OIP5-AS1 in contributing to tumorigenesis of osteosarcoma via the miR3p/PTN axis and, therefore outlining its potential for use as a therapeutic target against this cancer. +lncRNA target 32459973 hsa-mir-26b Nasopharyngeal Carcinoma FOXD3 has been found previously to positively regulate miR-26b, a tumor inhibitor of nasopharyngeal carcinoma (NPC). +circulation_biomarker_diagnosis_ns 32458821 hsa-mir-18a Carotid Artery Injuries MATERIAL AND METHODS miR-18a-5p expression was determined by fluorescence quantitative real-time polymerase chain reaction (qRT-PCR) analysis of tissues from 20 patients with stent restenosis, and rats with carotid artery injury, as well as VSMCs. RESULTS The expression level of miR-18a-5p was significantly higher in the blood serum of patients with stent restenosis and in rats with carotid artery injury, and the expression of AKT and ERK was higher after carotid artery injury. +circulation_biomarker_diagnosis_ns 32458821 hsa-mir-18a Graft Occlusion, Vascular MATERIAL AND METHODS miR-18a-5p expression was determined by fluorescence quantitative real-time polymerase chain reaction (qRT-PCR) analysis of tissues from 20 patients with stent restenosis, and rats with carotid artery injury, as well as VSMCs. RESULTS The expression level of miR-18a-5p was significantly higher in the blood serum of patients with stent restenosis and in rats with carotid artery injury, and the expression of AKT and ERK was higher after carotid artery injury. +other 32458732 hsa-mir-139 Brain Injuries, Traumatic Two miRNAs, hsa-miR5p and hsa-miR-18a-5p, were significantly differentially expressed in the rTBI and 1-2 mTBI groups. +other 32458732 hsa-mir-103a Brain Injuries TBI history and neurobehavioral symptom survey scores negatively and significantly correlated with hsa-miR-103a-3p expression. +other 32458732 hsa-mir-103a Brain Injuries, Traumatic TBI history and neurobehavioral symptom survey scores negatively and significantly correlated with hsa-miR-103a-3p expression. +other 32458732 hsa-mir-18a Brain Injuries Two miRNAs, hsa-miR5p and hsa-miR-18a-5p, were significantly differentially expressed in the rTBI and 1-2 mTBI groups. +other 32458732 hsa-mir-18a Brain Injuries, Traumatic Two miRNAs, hsa-miR5p and hsa-miR-18a-5p, were significantly differentially expressed in the rTBI and 1-2 mTBI groups. +other 32458732 hsa-mir-139 Brain Injuries Two miRNAs, hsa-miR5p and hsa-miR-18a-5p, were significantly differentially expressed in the rTBI and 1-2 mTBI groups. +other 32458638 hsa-mir-184 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: Our data indicated that miR-184, miR-378, miR-497, and miR-506 can be used as a potential diagnostic and prognostic biomarker in OSCC. +other 32458638 hsa-mir-506 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: Our data indicated that miR-184, miR-378, miR-497, and miR-506 can be used as a potential diagnostic and prognostic biomarker in OSCC. +other 32458638 hsa-mir-103 Squamous Cell Carcinoma of Head and Neck BACKGROUND: This study aimed to evaluate the expression patterns of miR-103, miR-184, miR-378, miR497 and in squamous cell carcinoma (SCC) of the tongue and to be compared with normal peripheral tissues. +other 32458638 hsa-mir-378 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: Our data indicated that miR-184, miR-378, miR-497, and miR-506 can be used as a potential diagnostic and prognostic biomarker in OSCC. +other 32458638 hsa-mir-497 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: Our data indicated that miR-184, miR-378, miR-497, and miR-506 can be used as a potential diagnostic and prognostic biomarker in OSCC. +other 32458624 hsa-mir-18a Breast Neoplasms CONCLUSION: APE can decrease miR-18a and MMP-9 expressions and increase Dicer1 expression in rat mammary cancer. +circulation_biomarker_diagnosis_ns 32458401 hsa-mir-208a ST Elevation Myocardial Infarction Accordingly, circulating levels of miR-208a can be used as a diagnostic marker of MI and a predictor of no-reflow and in-hospital MACE. +lncRNA target 32458348 hsa-mir-99a Allergic Inflammation While Ang-II induces Lin28B, which inhibits Let-7c/miR-99a miRNA processing and mature miRNA formation, this results in increased TNFalpha levels that lead to M1 polarization and allergic airway inflammation inhibition. +other 32457800 hsa-mir-200b Colorectal Neoplasms Further in-depth analysis identified the MFAP5-miR-200b-3p-AC005154.6 axis as a potential prognostic marker in CRC. In conclusion, MFAP5, miR-200b-3p, and AC005154.6 may have potential prognostic value in CRC and may provide a prognostic reference for this patient population. +other 32457613 hsa-mir-375 Urinary Bladder Neoplasms Circular RNA circKIF4A Sponges miR-375/1231 to Promote Bladder Cancer Progression by Upregulating NOTCH2 Expression. +other 32457603 hsa-mir-502 Uterine Cervical Neoplasms RESULTS: A combination of four miRNAs (down-regulated miR-502 and miR-145, up-regulated miR-142 and miR-33b) was identified as an independent prognostic signature of cervical cancer. Among them, two miRNAs (miR-502 and miR-33b) and two key genes (PTPRC and CDH5) were first reported to be potential novel biomarkers for cervical cancer. +circulation_biomarker_diagnosis_up 32457495 hsa-mir-1246 Pancreatic Carcinoma With a cut-off of the control group's mean plus twice the standard deviation, the sensitivities of MIR1246 in serum and urine for pancreatic cancer were 60.9 and 58.5%, respectively. +lncRNA target 32457485 hsa-mir-665 Ovarian Neoplasms Taken together, RHPN1-AS1 positively regulated the expression of Akt3 through sponging miR-665, and exerted an oncogenic role in ovarian cancer progression, and indicates that RHPN1-AS1 may be a potential therapeutic target in ovarian cancer. +lncRNA target 32457280 hsa-mir-222 Acute Lung Injury Our data indicated that miR-222 inhibition could alleviate SEB-induced inflammatory ALI by directly targeting Foxo3, shedding light on the potential therapeutic of miR-222 for SEB-induced inflammation in the lung. +lncRNA target 32457280 hsa-mir-222 Inflammation Our data indicated that miR-222 inhibition could alleviate SEB-induced inflammatory ALI by directly targeting Foxo3, shedding light on the potential therapeutic of miR-222 for SEB-induced inflammation in the lung. +circulation_biomarker_diagnosis_ns 32457253 hsa-mir-130a Neovascularization, Pathologic Forced expression of miR-130a could constitute a novel strategy to improve blood flow recovery and reduce ischemia in older patients with ischemic vascular diseases. +genetics_knock down_promote 32456490 hsa-mir-194 Uterine Cervical Neoplasms Conclusion: Knockdown of SNHG1 inhibited CC progression by targeting HCCR via sponging with miR-194. +genetics_GWAS 32456459 hsa-mir-145 Carcinoma, Non-Small-Cell Lung We provide the preliminary evidence for the role of TNFAIP2 in NSCLC progression and its epigenetic regulation mediated by microRNA, miR +lncRNA target 32456448 hsa-mir-2467 Carcinoma, Non-Small-Cell Lung Conclusion: SNHG20 contributed to NSCLC development through mediating AKT signaling pathway and sponging miR +lncRNA target 32456284 hsa-mir-23a Nerve Degeneration These regulated pathways of neurodegeneration may be the target of effective neuroprotective strategies using miR-23a-3p mimics to block their development and increase neuronal survival after irradiation. +other 32455798 hsa-mir-146a Osteoarthritis The aim of this study was to investigate the role of miR-34a, miR-146a, and miR-181a as possible mediators of HP effects on oxidative stress in human osteoarthritis (OA) chondrocytes. +other 32455798 hsa-mir-181a Osteoarthritis The aim of this study was to investigate the role of miR-34a, miR-146a, and miR-181a as possible mediators of HP effects on oxidative stress in human osteoarthritis (OA) chondrocytes. +other 32455798 hsa-mir-34a Osteoarthritis The aim of this study was to investigate the role of miR-34a, miR-146a, and miR-181a as possible mediators of HP effects on oxidative stress in human osteoarthritis (OA) chondrocytes. +circulation_biomarker_diagnosis_ns 32455724 hsa-mir-3 Fatty Liver These results suggest the involvement of miR-33, its associated hepatic bile acid synthesis, HDL formation, and cholesterol metabolism in mulberry fruit-mediated beneficial effects on serum and hepatic lipid abnormalities. +transcription factor target 32455716 hsa-mir-29a Liver Cirrhosis Our data provide new insights that therapeutic miR-29a improves cholestasis-induced hepatic inflammation and fibrosis and proteotstasis via blocking PI3KP85alpha, highlighting the potential of miR-29a targeted therapy for liver injury. +transcription factor target 32455716 hsa-mir-29a Cholestasis Our data provide new insights that therapeutic miR-29a improves cholestasis-induced hepatic inflammation and fibrosis and proteotstasis via blocking PI3KP85alpha, highlighting the potential of miR-29a targeted therapy for liver injury. +other 32455140 hsa-mir-141 Prostatic Neoplasms A significant increase was observed in the relative expression ratios of miR-141, miR-182, miR-200b, and miR-375 (1.89-, 2.09-, 2.41-, and 2.27-folds, respectively) in the PCa group when compared to the BPH group. +other 32455140 hsa-mir-375 Prostatic Hyperplasia A significant increase was observed in the relative expression ratios of miR-141, miR-182, miR-200b, and miR-375 (1.89-, 2.09-, 2.41-, and 2.27-folds, respectively) in the PCa group when compared to the BPH group. +other 32455140 hsa-mir-182 Prostatic Neoplasms A significant increase was observed in the relative expression ratios of miR-141, miR-182, miR-200b, and miR-375 (1.89-, 2.09-, 2.41-, and 2.27-folds, respectively) in the PCa group when compared to the BPH group. +other 32455140 hsa-mir-182 Prostatic Hyperplasia A significant increase was observed in the relative expression ratios of miR-141, miR-182, miR-200b, and miR-375 (1.89-, 2.09-, 2.41-, and 2.27-folds, respectively) in the PCa group when compared to the BPH group. +other 32455140 hsa-mir-141 Prostatic Hyperplasia A significant increase was observed in the relative expression ratios of miR-141, miR-182, miR-200b, and miR-375 (1.89-, 2.09-, 2.41-, and 2.27-folds, respectively) in the PCa group when compared to the BPH group. +other 32455140 hsa-mir-375 Prostatic Neoplasms A significant increase was observed in the relative expression ratios of miR-141, miR-182, miR-200b, and miR-375 (1.89-, 2.09-, 2.41-, and 2.27-folds, respectively) in the PCa group when compared to the BPH group. +other 32455140 hsa-mir-200b Prostatic Neoplasms A significant increase was observed in the relative expression ratios of miR-141, miR-182, miR-200b, and miR-375 (1.89-, 2.09-, 2.41-, and 2.27-folds, respectively) in the PCa group when compared to the BPH group. +other 32455140 hsa-mir-200b Prostatic Hyperplasia A significant increase was observed in the relative expression ratios of miR-141, miR-182, miR-200b, and miR-375 (1.89-, 2.09-, 2.41-, and 2.27-folds, respectively) in the PCa group when compared to the BPH group. +circulation_biomarker_diagnosis_ns 32455124 hsa-mir-103 Sepsis Serum levels of miR-103 have considerable diagnostic accuracy in distinguishing sepsis patients from SIRS patients and healthy controls. +transcription factor target 32454854 hsa-mir-663a Fibrosis These results show that miR-663a suppresses HSC proliferation and activation and the TGF-beta/Smad signaling pathway, highlighting that miR-663a can be utilized as a therapeutic target for hepatic fibrosis. +circulation_biomarker_diagnosis_up 32454849 hsa-mir-129 Fibrosis, Renal In vitro studies showed that NDK mixture-containing serum increased the expression of mir +circulation_biomarker_prognosis_up 32454494 hsa-mir-224 Carcinoma, Hepatocellular PURPOSE: The purpose of our study was to probe the mechanism of how miR-224/cytoplasmic polyadenylation element-binding protein 3 (CPEB3) axis is concerned with hepatocellular carcinoma (HCC). +lncRNA target 32454145 hsa-mir-152 Glioma CONCLUSION: NEAT1 enhanced glioma progression, partially through miR +genetics_knock down_suppress 32453706 hsa-mir-384 Colorectal Neoplasms In addition, repression of miR-384 or overexpression of AKT3 could partially rescue the inhibitory effect of DSCAM-AS1 knockdown on CRC progression. +genetics_knock down_promote 32453598 hsa-mir-338 Nasopharyngeal Neoplasms In conclusion, our findings demonstrated that circ_0000615 knockdown suppressed the growth of NPC cells via modulating miR +lncRNA target 32453597 hsa-mir-346 Carcinoma, Renal Cell miR-346 promoted the viability, migration, and invasion of RCC cells under hypoxia by targeting NDRG2. +lncRNA target 32453410 hsa-mir-26a Osteosarcoma Reduction of miR-26a-5p conversely promoted osteosarcoma cell viability and invasion. +lncRNA target 32453338 hsa-mir-543 Osteosarcoma CBX7, RAD9A, lncRNA SNHG7, miR-543, and miR-34a-5p may be explored as novel therapeutic targets for treatment of OS. +genetics_overexpression_promote 32453073 hsa-mir-7 Reperfusion Injury, Cerebral Ischemia Finally, rescue assays delineated sirt1 overexpression recovered the miR +lncRNA target 32453072 hsa-mir-515 Atherosclerosis More importantly, rescue assays delineated that inhibited expression of miR +genetics_overexpression_promote 32452339 hsa-mir-29a Fetal Macrosomia The overexpression of circulating miR-29a-5p, miR +genetics_overexpression_promote 32452339 hsa-mir-486 Fetal Macrosomia The overexpression of circulating miR-29a-5p, miR +genetics_overexpression_promote 32452339 hsa-mir-126 Fetal Macrosomia The overexpression of circulating miR-29a-5p, miR +genetics_overexpression_promote 32452339 hsa-mir-221 Fetal Macrosomia The overexpression of circulating miR-29a-5p, miR +lncRNA target 32452217 hsa-let-7b Carcinoma, Non-Small-Cell Lung In this research, let-7b-PAMAM (G5)-TPP and let-7b-PAMAM (G5)-TPP-HA nano-carriers were designed to deliver let-7b miRNA mimic to NSCLC cells' mitochondria as a novel way of cancer cells inhibition. +lncRNA target 32451840 hsa-mir-137 Schizophrenia Moreover, a protein-protein interaction network showed a central role for DISC1 and ZNF688 genes, and experimentally validated targets of MIR-137, such as and KCNB2, NRXN1, and SYN2, were identified among DM genes. +circulation_biomarker_diagnosis_down 32450789 hsa-mir-495 ankylosing spondylitis 1 METHODS: In this study, quantitative real-time polymerase chain reaction (PCR) was used to detect the expression of miR-495 in the peripheral blood mononuclear cells (PBMCs), whole blood, and serum of patients with AS. +lncRNA target 32450680 hsa-mir-19a Diabetic Retinopathy It was found that miR-19a inhibitor group exhibited an evidently lower protein expression of PTEN and a higher activation degree of the Akt pathway than DR group (P<0.05). +other 32450677 hsa-mir-542 Osteosarcoma 3p. +lncRNA target 32450521 hsa-mir-5047 Squamous Cell Carcinoma of Head and Neck LINC01207 boosted HNSCC cell proliferation and stemness characteristics via acting as a ceRNA of TNRC6B to bind miR-5047. In a word, present study uncovered a novel ceRNA mechanism of LINC01207/miR-5047/TNRC6B in HNSCC cells, which might contribute to HNSCC treatment. +transcription factor target 32450177 hsa-mir-1 Arrhythmias, Cardiac Taken together, this suggested that Met could play an important role in improving cardiac conduction delay through inhibition of miR-1 expression. +lncRNA target 32450169 hsa-mir-326 Asthma SIGNIFICANCE: Collectively, the data elucidates that circHIPK3 functions as a regulator in the airway remodeling during the asthma development through miR-326/STIM1 axis, providing a novel insight for the therapeutic target. +lncRNA target 32450163 hsa-mir-130a Carcinoma, Non-Small-Cell Lung Collectively, we demonstrated an anti-tumor role of miR-130a in NSCLC cells under hypoxia through targeting HIF1A, suggesting a potential target for the interfering of NSCLC. +other 32450149 hsa-mir-122 Non-alcoholic Fatty Liver Disease BACKGROUND & AIMS: Development of nonalcoholic steatohepatitis (NASH) is associated with reductions in hepatic microRNA122 (MIR122); the RAR related orphan receptor A (RORA) promotes expression of MIR122. +lncRNA target 32450002 hsa-mir-1278 Glioma CONCLUSIONS: Collectively, our observations demonstrate the tumor-suppressive function of LINC00294 in glioma development by sponging miR-1278 and promoting NEFM, suggesting a potential use in therapy for glioma. +lncRNA target 32449873 hsa-mir-143 Prostatic Neoplasms Here, we replaced the miRNA-143 in PC cells by using a vector-based miRNA-143 transfection approach.Materials and methods: The miRNA-143 vector was transfected into the cells and qRT-PCR was applied to assess the expression of target genes in PC3 cells. +transcription factor target 32449863 hsa-mir-126 Diabetic Nephropathies The inhibition of VEGF increased the effect of miR-126 down-expression on apoptosis and inflammation in diabetic nephropathy in vitro. +lncRNA target 32449803 hsa-mir-4458 Esophageal Squamous Cell Carcinoma Moreover, PBX silencing was found to restrain ESCC cell progression, while miR-4458 or HEIH vector both could alleviate its suppressive effect. +circRNA target 32449799 hsa-mir-654 Carcinoma, Non-Small-Cell Lung Therefore, these findings advocate targeting the hsa_circ_0085131/miR +exosome 32449597 hsa-mir-3473b Lung Neoplasms Blocking miR-3473b could reverse the exosome-mediated NF-kappaB activation of fibroblasts and decrease intrapulmonary colonization of lung tumour cells. Together, this study demonstrated that the miR-3473b in exosomes could mediate the interaction of lung tumour cells and local fibroblasts in metastatic sites and, therefore, enhance the metastasis of lung tumour cells. +genetics_overexpression_promote 32449438 hsa-mir-219a Myocardial Reperfusion Injury Moreover, overexpression of AIM2 or induction of the TLR4 pathway aggravated myocardial I/R injury alleviated by miR-219a. +epigenetics 32449389 hsa-mir-132 Sjogren's Syndrome Importantly, a 4-fold increase in microRNA132 expression, but not in other microRNAs, and increased DNA methylation in the promoter/noncoding region of serpina gene was observed in pSS, which could be responsible for the inhibition of alpha-1 antiproteinase antitrypsin expression in salivary gland cells of pSS patients. +other 32449280 hsa-mir-133a Urinary Bladder Neoplasms The miR-133a-3p/SLC12A5/SOX18/MMP7 signaling axis was critical for progression, and provided an effective therapeutic approach against bladder urothelial carcinoma. +genetics_overexpression_promote 32448371 hsa-mir-1271 Prostatic Neoplasms CONCLUSIONS: Taken together, overexpression of miR-1271 downregulates PES1 to activate the ERbeta signaling pathway, leading to the delayed prostate cancer development. +other 32447799 hsa-mir-130a Diabetes, Gestational In GDM placentas, the EVOO-enriched diet did not regulate PPAR protein expression or miR-130a expression, but prevented the reduced PPAR protein expression (P = .02 vs GDM) and the increased miR-518d expression (P = .009 vs GDM). +other 32447799 hsa-mir-518d Diabetes, Gestational In GDM placentas, the EVOO-enriched diet did not regulate PPAR protein expression or miR-130a expression, but prevented the reduced PPAR protein expression (P = .02 vs GDM) and the increased miR-518d expression (P = .009 vs GDM). +other 32447557 hsa-mir-29 Diabetic Retinopathy CONCLUSIONS: Therefore, VIM-AS1 may sponge miR-29 to participate in DR. +other 32447486 hsa-mir-155 Lung Neoplasms 5p and image the lung cancer cells. +circulation_biomarker_diagnosis_up 32447210 hsa-mir-17 Stomach Neoplasms RESULTS: This study showed that miR17-5p was upregulated in the plasma and tissues of patients with GC, while RUNX3 was downregulated in GC tissues. +lncRNA target 32447199 hsa-mir-27 Sleep Apnea, Obstructive Among all, CNR1 and CRY2 were found to be better targets for miR-27 and let-7 respectively as per ACE scores, ROC scores and expression fold change in OSA. +lncRNA target 32447199 hsa-let-7 Sleep Apnea, Obstructive Among all, CNR1 and CRY2 were found to be better targets for miR-27 and let-7 respectively as per ACE scores, ROC scores and expression fold change in OSA. +lncRNA target 32447074 hsa-mir-1 Osteoporosis 3p plays a pivotal role in the pathogenesis of osteoporosis via targeting SFRP1 and may be a potential therapeutic target for osteoporosis. +exosome 32446904 hsa-mir-210 Carcinoma, Non-Small-Cell Lung This study was assigned to expound the underlying mechanism of CAFs-derived exosomal miR-210 in non-small cell lung cancer (NSCLC) progression. +transcription factor target 32446383 hsa-mir-34c Osteosarcoma Taken together, our findings revealed that PLOD1 promoted tumorigenesis and metastasis in OS, and the dysregulated miR-34c/PLOD1/Hippo pathway affected OS progression, providing a potential therapeutic strategy for treatment. +lncRNA target 32446370 hsa-mir-92a Colorectal Neoplasms Rescues analysis indicated that miR-92a facilitated CRC cell growth and invasion via modulating the expression of AQP8. Our work validated that miR-92a regulated the aggressiveness of CRC cell via targeting AQP8. +genetics_overexpression_promote 32445972 hsa-mir-345 Squamous Cell Carcinoma of Head and Neck Furthermore, miR-345 overexpression in OSCC reduced both mRNA and protein expression of ZEB2. +lncRNA target 32445925 hsa-mir-143 Stomach Neoplasms All the data indicate that circFOXO3 promotes GC cell proliferation and migration by upregulating USP44 expression via targeting of miR +circulation_biomarker_diagnosis_down 32445843 hsa-mir-374b Venous Thrombosis RESULTS: Microarray and qRT-PCR results showed that the IL-10 expression was decreased while miR-374b-5p level was increased substantially in peripheral blood mononuclear cells of DVT patients, and there was significant negative correlation between miR-374b-5p and IL-10. +lncRNA target 32445780 hsa-mir-34a Stomach Neoplasms Our study was performed with the aim to explore the functional effects of miR-34a and its predictive target programmed death ligand 1 (PDL1) in gastric cancer development. +circRNA target 32445294 hsa-mir-150 Essential Hypertension 5p, which showed great potential as a novel target. +lncRNA target 32445273 hsa-mir-140 Breast Neoplasms CONCLUSIONS: Circ-RNF111 improved PTX resistance of BC by upregulating E2F3 via sponging miR +other 32445070 hsa-mir-495 Substance Abuse, Intravenous In short, the present study evaluated the roles of miR3p and IL5RA in IVDD development and progression. +other 32445070 hsa-mir-495 Lactate Dehydrogenase Deficiency 3p may be a potential agent for LDH, and our study may provide a novel strategy in LDH treatment. +lncRNA target 32445070 hsa-mir-495 Colorectal Neoplasms, Hereditary Nonpolyposis 3p promoted cell proliferation and inhibited inflammation and apoptosis in TNF-alpha-induced HNPCs. +other 32444974 hsa-mir-199a Gynatresia In our study, decreased miR-98 and miR-199a expressions were determined in Asherman syndrome. +other 32444974 hsa-mir-98 Gynatresia In our study, decreased miR-98 and miR-199a expressions were determined in Asherman syndrome. +exosome 32444593 hsa-mir-4448 Carcinoma, Non-Small-Cell Lung qRT-PCR confirmed the downregulation of miR-4448 in exosomes from lung adenocarcinoma patients compared with N-metastasis patients and healthy people. miR-4448 in exosomes has the potential to serve as a diagnostic marker of patients with adenocarcinoma metastasis. +circulation_biomarker_diagnosis_up 32443971 hsa-mir-132 Non-alcoholic Fatty Liver Disease CONCLUSIONS: Serum miR-132 was found to be associated with NAFLD risk in a Chinese cross-section study. +other 32443855 hsa-mir-21 Fibrosis Fibroblast treatment with MSC-EV led to direct transfer of microRNAs, which resulted in the elevation of most prominent fibrosis-associated microRNAs, including microRNA-21 and microRNA-29c. +other 32443855 hsa-mir-29c Fibrosis Fibroblast treatment with MSC-EV led to direct transfer of microRNAs, which resulted in the elevation of most prominent fibrosis-associated microRNAs, including microRNA-21 and microRNA-29c. +other 32443852 hsa-mir-1253 Hypertension Together, we have identified novel roles for miR-1253 and WASF2 in a hypertension-related disparities context. +lncRNA target 32443824 hsa-mir-370 Glioblastoma 3p acts as a tumor-suppressor factor inhibiting glioma cell growth, migration and invasion by targeting the lncRNAs NEAT1, HMGA2, and HIF1A, thus, providing a potential candidate for GBM patient treatment. +circulation_biomarker_diagnosis_ns 32443549 hsa-mir-92a Schistosomiasis The serum levels of three exomiRs (miR-92a-3p, miR-146a-5p and miR5p) were able to distinguish subjects with fibrosis grades I-III from those with no fibrosis, but only the serum level of exosomal miR-146a-5p showed potential for distinguishing patients with mild (grades 0-I) versus severe fibrosis (grades II-III). +circulation_biomarker_diagnosis_ns 32443549 hsa-mir-146a Schistosomiasis The serum levels of three exomiRs (miR-92a-3p, miR-146a-5p and miR5p) were able to distinguish subjects with fibrosis grades I-III from those with no fibrosis, but only the serum level of exosomal miR-146a-5p showed potential for distinguishing patients with mild (grades 0-I) versus severe fibrosis (grades II-III). +circulation_biomarker_diagnosis_ns 32443549 hsa-mir-92a Liver Cirrhosis The serum levels of three exomiRs (miR-92a-3p, miR-146a-5p and miR5p) were able to distinguish subjects with fibrosis grades I-III from those with no fibrosis, but only the serum level of exosomal miR-146a-5p showed potential for distinguishing patients with mild (grades 0-I) versus severe fibrosis (grades II-III). +other 32443549 hsa-mir-103a Schistosomiasis Of twelve RG candidates validated, miR-103a-3p and miR5p were determined to be the most stable genes in the murine schistosomiasis model and subjects from the schistosomiasis-endemic area, respectively. +circulation_biomarker_diagnosis_ns 32443549 hsa-mir-146a Liver Cirrhosis The serum levels of three exomiRs (miR-92a-3p, miR-146a-5p and miR5p) were able to distinguish subjects with fibrosis grades I-III from those with no fibrosis, but only the serum level of exosomal miR-146a-5p showed potential for distinguishing patients with mild (grades 0-I) versus severe fibrosis (grades II-III). +other 32443549 hsa-mir-425 Liver Cirrhosis Of twelve RG candidates validated, miR-103a-3p and miR5p were determined to be the most stable genes in the murine schistosomiasis model and subjects from the schistosomiasis-endemic area, respectively. +circulation_biomarker_diagnosis_ns 32443549 hsa-mir-532 Schistosomiasis The serum levels of three exomiRs (miR-92a-3p, miR-146a-5p and miR5p) were able to distinguish subjects with fibrosis grades I-III from those with no fibrosis, but only the serum level of exosomal miR-146a-5p showed potential for distinguishing patients with mild (grades 0-I) versus severe fibrosis (grades II-III). +other 32443549 hsa-mir-103a Liver Cirrhosis Of twelve RG candidates validated, miR-103a-3p and miR5p were determined to be the most stable genes in the murine schistosomiasis model and subjects from the schistosomiasis-endemic area, respectively. +circulation_biomarker_diagnosis_ns 32443549 hsa-mir-532 Liver Cirrhosis The serum levels of three exomiRs (miR-92a-3p, miR-146a-5p and miR5p) were able to distinguish subjects with fibrosis grades I-III from those with no fibrosis, but only the serum level of exosomal miR-146a-5p showed potential for distinguishing patients with mild (grades 0-I) versus severe fibrosis (grades II-III). +other 32443549 hsa-mir-425 Schistosomiasis Of twelve RG candidates validated, miR-103a-3p and miR5p were determined to be the most stable genes in the murine schistosomiasis model and subjects from the schistosomiasis-endemic area, respectively. +circulation_biomarker_diagnosis_ns 32443368 hsa-mir-25 Lung Neoplasms BACKGROUND: This study aims to identify the association between microRNA 25 (mRNA 25) expression in serum and lung cancer (LC). +transcription factor target 32443250 hsa-mir-133a Heart Defects, Congenital Moreover, we found that miR-133a agomir significantly alleviated the TCE-induced heart defects while miR-133a antagomir mimicked the toxic effect of TCE on heart development. In conclusion, our results indicate that miR-133a mediates TCE-induced ROS generation, leading to excessive cell proliferation and heart defects. +other 32442661 hsa-mir-181d Obesity Altering miR-181c expression may provide a pharmacologic approach to improve cardiomyopathy in individuals with obesity/type 2 diabetes. +other 32442661 hsa-mir-181c Obesity Altering miR-181c expression may provide a pharmacologic approach to improve cardiomyopathy in individuals with obesity/type 2 diabetes. +genetics_knock down_promote 32442477 hsa-mir-212 late onset Parkinson's disease CONCLUSION: NEAT1 knockdown suppressed MPP(+)-induced apoptosis, in fl ammation and cytotoxicity in SK-N-SH cells through regulating miR5p and RAB3IP expression, providing a possible therapeutic strategy for PD patients. +other 32442188 hsa-mir-155 Viral Respiratory Infections CONCLUSIONS: The airway secretion of miR-155 during viral respiratory infections in young children is associated with enhanced antiviral immunity (TH1 polarization). +genetics_overexpression_suppress 32441881 hsa-mir-383 Carcinoma, Hepatocellular Moreover, overexpression of miR-383 or silencing of PHF8 significantly inhibited the proliferation, migration, and invasion of HCC cells. +exosome 32441313 hsa-mir-10b Carcinoma, Hepatocellular 3p was found significantly upregulated in the exosome of HCC patients than CH/non-HCC. +exosome 32441313 hsa-mir-223 Carcinoma, Hepatocellular 3p was found significantly upregulated in the exosome of HCC patients than CH/non-HCC. +exosome 32441313 hsa-mir-21 Carcinoma, Hepatocellular 3p was found significantly upregulated in the exosome of HCC patients than CH/non-HCC. +other 32441313 hsa-mir-182 Carcinoma, Hepatocellular Transcriptome profiling for mRNA and small RNA in same HCV-HCC and normal liver tissues followed by cross-validation of 41 deregulated miRNAs (log(2) FoldChange > 1.5, P(adj) < .1) with GEO/TCGA datasets of HCV/HBV related HCC vs normal/adjacent tissue revealed three miRNAs were commonly deregulated (miR-10b/miR-21/miR-182) among all HCC irrespective of viral etiology. +exosome 32441313 hsa-mir-221 Carcinoma, Hepatocellular 3p was found significantly upregulated in the exosome of HCC patients than CH/non-HCC. +genetics_knock down_suppress 32441301 hsa-mir-543 Ovarian Neoplasms In addition, miR-543 also directly targeted SERPINI1, and miR-543 knockdown weakened the inhibitory effect of down-regulated SERPINI1 on OC progression. +transcription factor target 32441195 hsa-mir-136 Diabetes Mellitus Cell culture results showed that SYK was a target gene of miR-136 and miR-136/SYK-mediated renal fibrosis by activating TGF-beta1/Smad3 signal.Conclusion: SYK activates TGF-beta1/Smad3 signaling, while miR-136 inhibits TGF-beta1/Smad3 signaling mediating tubular epithelial cell fibrosis by down-regulating SYK. +transcription factor target 32441195 hsa-mir-136 Fibrosis, Renal Cell culture results showed that SYK was a target gene of miR-136 and miR-136/SYK-mediated renal fibrosis by activating TGF-beta1/Smad3 signal.Conclusion: SYK activates TGF-beta1/Smad3 signaling, while miR-136 inhibits TGF-beta1/Smad3 signaling mediating tubular epithelial cell fibrosis by down-regulating SYK. +lncRNA target 32440687 hsa-mir-195 Prostatic Neoplasms All in all, LINC00473 contributed to cell proliferation via JAK-STAT3 signaling pathway by regulating miR +transcription factor target 32440319 hsa-mir-22 Carcinoma, Non-Small-Cell Lung OBJECTIVES: To investigate the role of miR-22 in the efficacy of combined icotinib (BPI-2009H) and pemetrexed (LY-231514) on tumor growth and apoptosis in rats with non-small cell lung cancer (NSCLC). CONCLUSION: Inhibition of miR-22 could enhance the efficacy of icotinib combined with pemetrexed in rats with NSCLC, providing a new perspective for NSCLC therapy. +genetics_knock down_suppress 32440218 hsa-mir-181a Carcinoma, Non-Small-Cell Lung Moreover, miR-181a-5p inhibition or E2F7 overexpression abolished the effect of SNHG7 knockdown on the progression of NSCLC cells. +lncRNA target 32440207 hsa-mir-195 Carcinoma, Renal Cell CONCLUSION: Our study provides a novel mechanism of TTN-AS1/miR-195/cyclin D1 regulatory axis in ccRCC, which may become a breakthrough for ccRCC therapy in the future. +genetics_overexpression_promote 32440153 hsa-mir-25 Carcinoma, Non-Small-Cell Lung 3p, and its silencing also could reverse the inhibition effect of overexpressed-hsa_circ_0043265 on NSCLC progression. +lncRNA target 32440152 hsa-mir-377 Osteosarcoma 3p and FOSL2 was a target of miR +lncRNA target 32440147 hsa-mir-145 Liver Neoplasms The current study investigated the mechanism underlying microRNA (miR-145)-mediated inhibition of Th9 cells in an malignant ascites model with liver cancer. +genetics_overexpression_promote 32440141 hsa-mir-135b Carcinoma, Non-Small-Cell Lung Furthermore, circLARP4 overexpression inhibited the PTEN/AKT/HIF-1alpha pathway in NSCLC cells and xenograft tumors by downregulating miR-135b. +lncRNA target 32439866 hsa-mir-32 Retinoblastoma Our results reveal a potential competing endogenous RNA regulatory pathway, in which lincRNA-ROR modulates the epithelial-mesenchymal transition program by competitively binding to endogenous miR5p and regulating Notch signaling pathway activity in retinoblastoma cells, which may provide new insights into novel molecular therapeutic targets for retinoblastoma. +circulation_biomarker_diagnosis_ns 32439831 hsa-mir-15a Diabetes Mellitus In summary, inhibition of circulating exosomal miR-15a-3p accelerated diabetic wound repair by activating NOX5, providing a novel therapeutic target for diabetic foot ulcer therapy. +other 32439590 hsa-mir-7240 Liver Diseases This study revealed Gm20319-miR5p-GNE network reduced sialic acid level to influence the expression of SOD1 and IL-1beta in liver, which might involve in liver damage induced by DON. +transcription factor target 32439493 hsa-mir-142 Mitochondrial Diseases 5p via targeting Miro1 inhibits neuronal death and mitochondrial dysfunction, and thus attenuates pilocarpine-induced SE, suggesting the potential involvement of miR +transcription factor target 32439493 hsa-mir-142 Epilepsy 5p via targeting Miro1 inhibits neuronal death and mitochondrial dysfunction, and thus attenuates pilocarpine-induced SE, suggesting the potential involvement of miR +lncRNA target 32439493 hsa-mir-142 Hemochromatosis 5p antagomirs via intracerebroventricular injection attenuated pilocarpine-induced SE and hippocampal damage, and alleviated mitochondrial dysfunction along with increased mitochondrial membrane potential and intracellular ATP and Ca (2+) levels. +transcription factor target 32439493 hsa-mir-142 Sarcoma, Ewing 5p via targeting Miro1 inhibits neuronal death and mitochondrial dysfunction, and thus attenuates pilocarpine-induced SE, suggesting the potential involvement of miR +genetics_GWAS 32439373 hsa-mir-106 Weight Loss CONCLUSION: Diet induced weight loss leads to SNP dependent modulation of miRNAs from the miR 25/93/106 gene cluster in humans. +genetics_GWAS 32439373 hsa-mir-25 Weight Loss CONCLUSION: Diet induced weight loss leads to SNP dependent modulation of miRNAs from the miR 25/93/106 gene cluster in humans. +genetics_GWAS 32439373 hsa-mir-93 Weight Loss CONCLUSION: Diet induced weight loss leads to SNP dependent modulation of miRNAs from the miR 25/93/106 gene cluster in humans. +other 32439252 hsa-mir-320c Lung Diseases miR-320c Regulates SERPINA1 Expression and Is Induced in Patients With Pulmonary Disease. +lncRNA target 32438863 hsa-mir-146a Colorectal Neoplasms Our results suggest that single-nucleotide variant rs2910164 does not influence the colorectal cancer risk in Brazilian patients; however, the GG genotype could act as a factor of worse prognosis in patients with advanced disease due to suppression of BRCA1/2 modulated by miR-146a. +lncRNA target 32438838 hsa-mir-146a Choroidal Neovascularization CONCLUSIONS: Our results indicated that downregulation of miR-146a-5p inhibited experimental CNV formation via inactivation of the NF-kappaB signaling pathway. +circulation_biomarker_prognosis_ns 32438598 hsa-mir-155 Carcinoma, Non-Small-Cell Lung The expression of microRNA (miR)-21, miR-128, miR-155, and miR-181a involved in DNA damage response (DDR) and tumor responsiveness to platinum was assessed by RT-qPCR in the plasma of patients with non-small cell lung cancer (NSCLC; n = 128) obtained prior to initiation of first-line platinum chemotherapy. Our study shows for the first time that plasma miR-128 and miR-155 hold independent prognostic implications in NSCLC patients treated with platinum-based chemotherapy possibly related to their involvement in tumor response to hypoxia. +other 32438598 hsa-mir-21 Carcinoma, Non-Small-Cell Lung In the squamous (SqCC) subgroup (n = 41), besides miR-128 and miR-155, high miR-21 and miR-181a expressions were also associated with worse survival and high miR-155 independently predicted for shorter OS. +circulation_biomarker_prognosis_ns 32438598 hsa-mir-128 Carcinoma, Non-Small-Cell Lung The expression of microRNA (miR)-21, miR-128, miR-155, and miR-181a involved in DNA damage response (DDR) and tumor responsiveness to platinum was assessed by RT-qPCR in the plasma of patients with non-small cell lung cancer (NSCLC; n = 128) obtained prior to initiation of first-line platinum chemotherapy. Our study shows for the first time that plasma miR-128 and miR-155 hold independent prognostic implications in NSCLC patients treated with platinum-based chemotherapy possibly related to their involvement in tumor response to hypoxia. +other 32438598 hsa-mir-181a Carcinoma, Non-Small-Cell Lung In the squamous (SqCC) subgroup (n = 41), besides miR-128 and miR-155, high miR-21 and miR-181a expressions were also associated with worse survival and high miR-155 independently predicted for shorter OS. +transcription factor target 32437796 hsa-mir-619 Liver Neoplasms 5p inhibits cancer cell proliferation by targeting PSMD10, and miR +lncRNA target 32437330 hsa-mir-1264 Colorectal Neoplasms Taken together, our results identified a novel regulatory loop in which SOCS2-AS1/miR-1264/SOCS2 axis suppresses CRC progression. +genetics_overexpression_promote 32436934 hsa-mir-4561 Carcinoma, Hepatocellular Then, miR-4561 overexpression obviously repressed the proliferation and promoted apoptosis in two HCC cell lines. +other 32436503 hsa-mir-21 Esophageal Neoplasms Herein, we demonstrate the direct detection of the esophageal cancer biomarker, miR-21, in RNA extracted from 17 endoscopic tissue biopsies using the nanophotonics technology our group has developed, termed the inverse molecular sentinel (iMS) nanobiosensor, with surface-enhanced Raman scattering (SERS) detection. +genetics_overexpression_promote 32436353 hsa-mir-141 Breast Neoplasms In addition, the overexpression of miR +genetics_overexpression_promote 32436333 hsa-mir-605 Carcinoma, Hepatocellular Overexpression of miR +genetics_knock down_suppress 32435875 hsa-mir-485 Carcinoma, Hepatocellular LncRNA RHPN1-AS1 knockdown decreased the capacity of proliferation, invasion, and migration in HCCLM3 and SMMC-7721 cells, which could be crippled by miR +lncRNA target 32435616 hsa-mir-200b Lung Neoplasms We determined that lung cancer patient tumor samples exhibit decreased miR-200b expression, and we further found this miRNA to inhibit tumor growth via interfering with ERK1/2 and AKT signaling, targeting p70S6K1 to suppress HIF-1alpha expression. +circulation_biomarker_prognosis_up 32435610 hsa-mir-665 Hepatitis C, Chronic CONCLUSIONS: Using measurement against AFP level in serum, miR-665 is considered a promising serum biomarker for the diagnosis of HCC patients among the LC patients without HCC. +circulation_biomarker_prognosis_up 32435610 hsa-mir-665 Carcinoma, Hepatocellular CONCLUSIONS: Using measurement against AFP level in serum, miR-665 is considered a promising serum biomarker for the diagnosis of HCC patients among the LC patients without HCC. +transcription factor target 32435510 hsa-mir-125b Pre-Eclampsia We then investigated the underlying molecular mechanisms between miR-125b and PE in vitro. The findings indicated that upregulated miR-125b leads to impaired placentation, and an increased risk of preeclampsia, Our studies provide novel insights into the underlying mechanisms on the association of miR-125b in early pregnancy and risk of PE, miR-125b might be a more specific predictive marker and a safe therapeutic target for treating patients with PE. +lncRNA target 32435156 hsa-mir-146a Carcinoma, Hepatocellular CONCLUSIONS: MALAT1 may modulate HCC cell proliferation, apoptosis, and autophagy via sponging miR-146a, which regulates HCC progression. +other 32435051 hsa-mir-26a Cholangiocarcinoma CONCLUSIONS Bioinformatics analysis identified ESR1 and hsa-miR-26a-5p as potential prognostic biomarkers for intrahepatic cholangiocarcinoma. +lncRNA target 32434960 hsa-mir-675 Bone Diseases The results suggested that HAMSCs promote osteogenic differentiation of HBMSCs via H19/miR-675/APC pathway, and supply a potential target for the therapeutic treatment of bone-destructive diseases. +other 32434960 hsa-mir-675 Atrial Premature Complexes Mechanistically, H19 promoted miR-675 expression and contributed to the competitively bounding of miR-675 and Adenomatous polyposis coli (APC), thus significantly activating the Wnt/beta-catenin pathway. +lncRNA target 32434960 hsa-mir-675 Adenomatous Polyposis Coli Mechanistically, H19 promoted miR-675 expression and contributed to the competitively bounding of miR-675 and Adenomatous polyposis coli (APC), thus significantly activating the Wnt/beta-catenin pathway. The results suggested that HAMSCs promote osteogenic differentiation of HBMSCs via H19/miR-675/APC pathway, and supply a potential target for the therapeutic treatment of bone-destructive diseases. +genetics_knock down_promote 32434194 hsa-mir-129 Parkinson Disease The knockdown of miR +genetics_knock down_promote 32434194 hsa-mir-129 Alzheimer Disease The knockdown of miR +other 32433480 hsa-mir-129 Alzheimer Disease Finally, we confirmed the upregulation of miR-129 in the hippocampus of brains of rats with scopolamine-induced amnesia as a model of Alzheimer's disease. We suggest that future research should investigate the possible role of miR-129 in synaptic plasticity and Alzheimer's disease. +lncRNA target 32433053 hsa-mir-26a Pancreatic Carcinoma We aimed to unmask the role that long non-coding RNA small nucleolar RNA host gene 6 (SNHG6) plays in PC cells by targeting far upstream element binding protein 1 (FUBP1) via microRNA-26a-5p (miR-26a-5p). +circulation_biomarker_diagnosis_ns 32432792 hsa-mir-128 Multiple Sclerosis CONCLUSIONS Serum levels of mir +lncRNA target 32432774 hsa-mir-122 Thyroid Cancer, Papillary CONCLUSIONS: Propofol suppresses migration, invasion, and EMT in papillary thyroid carcinoma cells by regulating miR-122 expression. +circulation_biomarker_diagnosis_ns 32432764 hsa-mir-145 Coronary Disease RESULTS: The expression of serum miR +genetics_knock down_promote 32432757 hsa-mir-655 Leukemia, Myeloid, Acute 3p directly targeted CCND1, and CCND1 overexpression attenuated miR +other 32432754 hsa-mir-210 Melanoma Our aim was to compare the effect of HIF-1alpha and miR-210 on the metabolism of malignant melanoma cells in normoxia and pseudohypoxia. +lncRNA target 32432753 hsa-mir-154 Glioma CONCLUSIONS: SNHG11 functioned as an oncogene in glioma and promoted proliferation, invasion, and migration via EMT by sponging miR5p. +genetics_overexpression_promote 32432752 hsa-mir-224 Thyroid Cancer, Papillary Of note, overexpression of EGR2 attenuated the carcinogenic effects of miR +lncRNA target 32432750 hsa-mir-216b Breast Neoplasms GAS5 can target on miR-216b to regulate the biological behavior and epithelial-mesenchymal transition of breast cancer cells. +lncRNA target 32432748 hsa-mir-124 Laryngeal Neoplasms Furthermore, the miR-124/PLOD2 axis might become a potential target for the treatment of LC. +genetics_overexpression_promote 32432747 hsa-mir-149 Adenocarcinoma of Lung Functionally, overexpression of miR-149 inhibited cell viability and metastasis in LAD. +genetics_overexpression_promote 32432746 hsa-mir-365 Adenocarcinoma of Lung Functionally, the overexpression of miR-365 inhibited proliferation, migration, and invasion of lung adenocarcinoma cells. +lncRNA target 32432745 hsa-mir-155 Carcinoma, Non-Small-Cell Lung Therefore, the MIR155HG/miR-155 axis may be a potential therapeutic target for NSCLC. +lncRNA target 32432744 hsa-mir-376b Carcinoma, Non-Small-Cell Lung Moreover, NEAT1 regulated SULF1 expression via binding to miR-376b-3p in NSCLC cells. CONCLUSIONS: In this study, we found that lncRNA NEAT1 regulated cell proliferation, invasion, migration, and apoptosis by targeting has-miR-376b-3p/SULF1 axis in NSCLC. +lncRNA target 32432743 hsa-mir-92a Squamous Cell Carcinoma of Head and Neck Subsequently, the effects of miR-92a silencing on proliferation and apoptosis of OSCC cells were determined via cell counting kit-8 (CCK-8) assay, flow cytometry, and colony formation assay, respectively. +other 32432741 hsa-mir-1301 Esophageal Squamous Cell Carcinoma CONCLUSIONS: Linc01433 participated in ESCC progression by regulating miR-1301 and it could function as a novel biomarker in ESCC diagnosis and treatment. +lncRNA target 32432740 hsa-mir-1324 Stomach Neoplasms Inhibition of microRNA-1324 remarkably enhanced the proliferative capacity and invasiveness of GCa cells. +lncRNA target 32432735 hsa-mir-193a Urinary Bladder Neoplasms ZNFX1-AS1 expression was negatively correlated with miR-193a-3p expression, but positively correlated with SDC1 expression in bladder cancer samples. CONCLUSIONS: ZNFX1-AS1 regulated bladder cancer progression by targeting the miR-193a-3p/SDC1 axis. +transcription factor target 32432734 hsa-mir-219 Prostatic Neoplasms CONCLUSIONS: MiR5p suppresses the growth and metastasis abilities of prostate cancer cells by directly repressing the expression of HMGA2. +lncRNA target 32432733 hsa-mir-5590 Prostatic Neoplasms Of note, we discovered that SNHG14 could promote cell proliferation, invasion, and repress cell apoptosis via miR +genetics_overexpression_promote 32432732 hsa-mir-377 Uterine Cervical Neoplasms 3p overexpression in CC. +genetics_overexpression_promote 32432730 hsa-mir-32 Ovarian Neoplasms The overexpression of miR-32 significantly inhibited the proliferation, migration, and invasion of ovarian cancer cells. +other 32432698 hsa-mir-20b Pancreatic Carcinoma Consequently, we extrapolated that SNHG12/miR-320b could be invoked as a promising early diagnostic hallmark and therapeutic strategy for pancreatic cancer. +lncRNA target 32432654 hsa-mir-342 Uterine Cervical Neoplasms 3p to mediate FXYD3 expression, providing promising therapeutic targets for CC patients. +other 32432496 hsa-mir-29a Corneal dystrophy, epithelial basement membrane By means of stepwise reverse prediction and validation from mRNA to lncRNA, a ceRNA network comprised of H19, miR-29a-3p, COL3A1, COL5A2, COL1A2 and COL4A1 was constructed, and all genes in the network are significantly correlated with the prognosis of GC patients. +other 32432483 hsa-mir-1246 Severe Acute Respiratory Syndrome The first step in SARS-CoV-2 infection is binding of the virus to ACE2 (angiotensin-converting enzyme 2) on the airway epithelium.Objectives: The objective was to gain insight into the expression of ACE2 in the human airway epithelium.Methods: Airway epithelia sampled by fiberoptic bronchoscopy of trachea, large airway epithelia (LAE), and small airway epithelia (SAE) of nonsmokers and smokers were analyzed for expression of ACE2 and other coronavirus infection-related genes using microarray, RNA sequencing, and 10x single-cell transcriptome analysis, with associated examination of ACE2-related microRNA.Measurements and Main Results: 1) ACE2 is expressed similarly in the trachea and LAE, with lower expression in the SAE; 2) in the SAE, ACE2 is expressed in basal, intermediate, club, mucus, and ciliated cells; 3) ACE2 is upregulated in the SAE by smoking, significantly in men; 4) levels of miR-1246 expression could play a role in ACE2 upregulation in the SAE of smokers; and 5) ACE2 is expressed in airway epithelium differentiated in vitro on air-liquid interface cultures from primary airway basal stem/progenitor cells; this can be replicated using LAE and SAE immortalized basal cell lines derived from healthy nonsmokers.Conclusions: ACE2, the gene encoding the receptor for SARS-CoV-2, is expressed in the human airway epithelium, with variations in expression relevant to the biology of initial steps in SARS-CoV-2 infection. +other 32432483 hsa-mir-1246 COVID-19 The first step in SARS-CoV-2 infection is binding of the virus to ACE2 (angiotensin-converting enzyme 2) on the airway epithelium.Objectives: The objective was to gain insight into the expression of ACE2 in the human airway epithelium.Methods: Airway epithelia sampled by fiberoptic bronchoscopy of trachea, large airway epithelia (LAE), and small airway epithelia (SAE) of nonsmokers and smokers were analyzed for expression of ACE2 and other coronavirus infection-related genes using microarray, RNA sequencing, and 10x single-cell transcriptome analysis, with associated examination of ACE2-related microRNA.Measurements and Main Results: 1) ACE2 is expressed similarly in the trachea and LAE, with lower expression in the SAE; 2) in the SAE, ACE2 is expressed in basal, intermediate, club, mucus, and ciliated cells; 3) ACE2 is upregulated in the SAE by smoking, significantly in men; 4) levels of miR-1246 expression could play a role in ACE2 upregulation in the SAE of smokers; and 5) ACE2 is expressed in airway epithelium differentiated in vitro on air-liquid interface cultures from primary airway basal stem/progenitor cells; this can be replicated using LAE and SAE immortalized basal cell lines derived from healthy nonsmokers.Conclusions: ACE2, the gene encoding the receptor for SARS-CoV-2, is expressed in the human airway epithelium, with variations in expression relevant to the biology of initial steps in SARS-CoV-2 infection. +genetics_overexpression_promote 32432318 hsa-let-7a Squamous Cell Carcinoma of Head and Neck In vitro and in vivo experiments demonstrated that let-7a overexpression could inhibit cell proliferation and tumor growth of LSCC and simultaneously down-regulate the expression of HMGA2. +other 32432317 hsa-mir-195 Ossification of Posterior Longitudinal Ligament We validated that ADORA2A was expressed highly, while miR-497 and miR-195 were down-regulated in PLL tissues of OPLL patients. +genetics_overexpression_promote 32432317 hsa-mir-195 Protein-Losing Enteropathies Overexpression of miR-195 and miR-497 diminished expression of osteogenic factors in PLL cells by inactivating the cAMP/PKA signaling pathway via down-regulation of ADORA2A. +other 32432317 hsa-mir-497 Ossification of Posterior Longitudinal Ligament We validated that ADORA2A was expressed highly, while miR-497 and miR-195 were down-regulated in PLL tissues of OPLL patients. +genetics_overexpression_promote 32432317 hsa-mir-497 Protein-Losing Enteropathies Overexpression of miR-195 and miR-497 diminished expression of osteogenic factors in PLL cells by inactivating the cAMP/PKA signaling pathway via down-regulation of ADORA2A. +lncRNA target 32432314 hsa-mir-137 Osteoarthritis CONCLUSION: miR-137 targets the inhibition of TCF4 to reverse the progression of OA through the AMPK/NF-kappaB signaling pathway. +other 32432120 hsa-mir-150 Crohn Disease MicroRNAs miR-29c, miR-155 miR-150, and miR-155, which have been demonstrated to contribute to fibrosis in various organs, showed significant deregulation in CD. +other 32432120 hsa-mir-155 Crohn Disease MicroRNAs miR-29c, miR-155 miR-150, and miR-155, which have been demonstrated to contribute to fibrosis in various organs, showed significant deregulation in CD. +other 32432120 hsa-mir-29c Crohn Disease MicroRNAs miR-29c, miR-155 miR-150, and miR-155, which have been demonstrated to contribute to fibrosis in various organs, showed significant deregulation in CD. +genetics_knock down_promote 32432112 hsa-mir-362 Carcinoma, Renal Cell Knockdown of SP1 expression by a small interfering RNA (siRNA) phenocopied the effect of miR +transcription factor target 32431616 hsa-mir-138 Prostatic Neoplasms To summarize, our findings suggested that APS inhibits tumorigenesis and lipid metabolism through miR5p/SIRT1/SREBP1 pathways in PCa. +target gene 32431548 hsa-mir-184 gastric adenocarcinoma LncRNA HAND2-AS1 could inhibit GA cell proliferation, migration and invasion abilities and glycolytic process induced by hypoxia through miR-184/HIF3A signaling. +genetics_overexpression_promote 32431544 hsa-mir-26a Carcinoma, Hepatocellular The rate of proliferation, invasion, apoptosis, and expression levels of related proteins of HCC cells overexpressing miR-26a-5p or those after knocking down HMGA2 expression were detected by MTT, invasion and apoptosis rate tests. +target gene 32431539 hsa-mir-27a Uterine Cervical Neoplasms MiR-27a-3p Regulated the Aggressive Phenotypes of Cervical Cancer by Targeting FBXW7. +genetics_knock down_promote 32431519 hsa-mir-122 Colorectal Neoplasms Circ_0007142 knockdown impeded cell proliferation, colony formation, migration, and invasion in CRC cells by regulating miR +genetics_knock down_promote 32431516 hsa-mir-101 Colonic Neoplasms 3p reverses the anti-tumor effect of MALAT1 knockdown on CC cells. +target gene 32431515 hsa-mir-1236 Lung Neoplasms Long Non-Coding RNA NNT-AS1 Contributes to Cisplatin Resistance via miR-1236-3p/ATG7 Axis in Lung Cancer Cells. +target gene 32431512 hsa-mir-138 Colorectal Neoplasms MiR-138 Suppresses the PDK1 Expression to Decrease the Oxaliplatin Resistance of Colorectal Cancer. +transcription factor target 32431510 hsa-mir-375 Carcinoma, Hepatocellular Finally, we showed that miR-375 affected sensitivity of HCC cells to sorafenib through regulation of ATG14. +target gene 32431508 hsa-mir-217 Colorectal Neoplasms FNDC3B, Targeted by miR-125a-5p and miR-217, Promotes the Proliferation and Invasion of Colorectal Cancer Cells via PI3K/mTOR Signaling. +target gene 32431508 hsa-mir-125a Colorectal Neoplasms FNDC3B, Targeted by miR-125a-5p and miR-217, Promotes the Proliferation and Invasion of Colorectal Cancer Cells via PI3K/mTOR Signaling. +other 32431171 hsa-mir-655 Osteoporosis 3p in OP therapy. +transcription factor target 32430024 hsa-mir-374b Carcinoma, Hepatocellular ABCA8 was down-regulated by miR-374b-5p; this down-regulation can induce epithelial transformation to mesenchyme via the ERK/ZEB1 signaling pathway and promote HCC progression. These findings may lead to a new targeted therapy for HCC through the regulation of ABCA8, and miR-374b-5p. +other 32429773 hsa-mir-365 Colonic Neoplasms miRNA-365 and miRNA-145 are downregulated in colorectal cancer (CRC) but not in healthy tissues. +other 32429773 hsa-mir-145 Colonic Neoplasms miRNA-365 and miRNA-145 are downregulated in colorectal cancer (CRC) but not in healthy tissues. +lncRNA target 32429724 hsa-mir-345 Heart Failure Moreover, Smad3 was a target of miR3p.Discussion and Conclusions: The beneficial effects of QL on DOX-induced CHF in rats are mediated by reduction in myocardial fibrosis, promotion of TGF-beta3/Smad7, and inhibition of TGF-beta1/Smad3. +lncRNA target 32429150 14q32 cluster Instent Restenosis Direct inhibition of 14q32 microRNA miR3p decreased postinterventional restenosis via inhibition of both vascular smooth muscle cell (VSMC) proliferation and local inflammation. +lncRNA target 32429150 14q32 cluster Inflammation Direct inhibition of 14q32 microRNA miR3p decreased postinterventional restenosis via inhibition of both vascular smooth muscle cell (VSMC) proliferation and local inflammation. +lncRNA target 32429150 hsa-mir-495 Instent Restenosis Direct inhibition of 14q32 microRNA miR3p decreased postinterventional restenosis via inhibition of both vascular smooth muscle cell (VSMC) proliferation and local inflammation. +lncRNA target 32429150 hsa-mir-495 Inflammation Direct inhibition of 14q32 microRNA miR3p decreased postinterventional restenosis via inhibition of both vascular smooth muscle cell (VSMC) proliferation and local inflammation. +circulation_biomarker_diagnosis_ns 32429037 hsa-mir-409 Atrial Fibrillation We used quantitative PCR (qPCR) to determine the relative plasma levels of circulating miRNAs expressed in the heart or associated with atrial remodeling or fibrillation with reported altered plasma/serum levels in AF: miR-146a-5p, miR +circulation_biomarker_diagnosis_ns 32429037 hsa-mir-150 Atrial Fibrillation We used quantitative PCR (qPCR) to determine the relative plasma levels of circulating miRNAs expressed in the heart or associated with atrial remodeling or fibrillation with reported altered plasma/serum levels in AF: miR-146a-5p, miR +circulation_biomarker_diagnosis_ns 32429037 hsa-mir-21 Atrial Fibrillation Additionally, we found that miR-320a-3p, miR5p, and miR-146a-5p plasma levels positively correlated with the CHA(2)DS(2)-Vasc score and were elevated in subjects with CHA(2)DS(2)-Vasc >/= 2. +circulation_biomarker_diagnosis_ns 32429037 hsa-mir-20a Atrial Fibrillation First, in a cohort of 90 adult outpatient clinic patients, we found that the plasma level of miR-320a-3p was elevated in PAF patients compared to healthy controls and hypertensive patients without AF. Our results indicate that, amongst the analyzed miRNAs, miR-320a-3p may be considered as a potential PAF circulating plasma biomarker, leading to speculation as to whether this miRNA is a marker of platelet state change due to ACEI therapy. +circulation_biomarker_diagnosis_ns 32429037 hsa-mir-19a Atrial Fibrillation We used quantitative PCR (qPCR) to determine the relative plasma levels of circulating miRNAs expressed in the heart or associated with atrial remodeling or fibrillation with reported altered plasma/serum levels in AF: miR-146a-5p, miR +circulation_biomarker_diagnosis_ns 32429037 hsa-mir-28 Atrial Fibrillation We used quantitative PCR (qPCR) to determine the relative plasma levels of circulating miRNAs expressed in the heart or associated with atrial remodeling or fibrillation with reported altered plasma/serum levels in AF: miR-146a-5p, miR +circulation_biomarker_diagnosis_ns 32429037 hsa-mir-146a Atrial Fibrillation Additionally, we found that miR-320a-3p, miR5p, and miR-146a-5p plasma levels positively correlated with the CHA(2)DS(2)-Vasc score and were elevated in subjects with CHA(2)DS(2)-Vasc >/= 2. +genetics_knock down_promote 32428930 hsa-mir-1 Aortic Dissection Gain-of-function and loss-of-function studies verified that miR +genetics_knock down_promote 32428930 hsa-mir-1 Aortic Aneurysm, Abdominal Gain-of-function and loss-of-function studies verified that miR +genetics_knock down_suppress 32428870 hsa-mir-124 Prostatic Neoplasms Knockdown of OGFRP1 and overexpression of miR +genetics_knock down_promote 32428232 hsa-mir-378a Retinoblastoma The overexpression of miR-378a-3p was found to decrease RB cell viability and to promote cell apoptosis in vitro, whereas overexpressed FOXG1 reversed the regulatory effects of miR-378a-3p on RB cellular behaviors. +exosome 32427870 hsa-mir-21 Colon Adenocarcinoma Our study suggests that targeted inhibition of exosomes, particularly those carrying miR-21, may represent a novel approach for treatment of colorectal cancer. +transcription factor target 32427806 hsa-mir-1906 Brain Ischemia miR-1906 could protect cerebral ischemic injury through activating the JAK2/STAT3 pathway in rats. +genetics_knock down_promote 32427740 hsa-mir-496 Prostatic Neoplasms TUG1 knockdown suppressed PC cell proliferation, migration and invasion in vitro and curbed PC xenograft growth in vivo by regulating miR-496/Wnt/ beta-catenin signaling pathway, deepening our understanding on etiology of PC. +genetics_overexpression_promote 32427712 hsa-mir-138 Glioblastoma Cell counting kit-8 assay showed that miR-138 overexpression resulted in decreased proliferation rate of GBM cells. Therefore, SNHG4 regulates miR-138/c-Met axis to promote the proliferation of GBM cells. +transcription factor target 32427576 hsa-mir-125a Pulmonary Arterial Hypertension CONCLUSION: In vitro and in vivo experiments both confirmed that miR-125a-5p could inhibit cell glycolysis and PASMC proliferation to improve PAH by targeting HK-II. +transcription factor target 32427128 hsa-mir-16 Osteoporosis, Postmenopausal These findings suggest that miR5p suppresses osteogenesis by inhibiting VEGFA expression and is a promising target for postmenopausal osteoporosis therapy. +lncRNA target 32426838 hsa-mir-26a Esophageal Squamous Cell Carcinoma Furthermore, CKS2 was observed as a direct target of miR-26a-5p, and CKS2 controlled the growth of EC cells via the MDM2/p53/Bcl2/Bax pathway. +circulation_biomarker_diagnosis_ns 32426280 hsa-mir-222 Cardiotoxicity Conclusions: Serum miR +circulation_biomarker_diagnosis_ns 32426280 hsa-mir-222 Breast Neoplasms Conclusions: Serum miR +other 32426273 hsa-mir-17 Lung Neoplasms miR-93, miR-373, and miR-17-5p Negatively Regulate the Expression of TBP2 in Lung Cancer. +other 32426273 hsa-mir-373 Lung Neoplasms miR-93, miR-373, and miR-17-5p Negatively Regulate the Expression of TBP2 in Lung Cancer. +other 32426273 hsa-mir-93 Lung Neoplasms miR-93, miR-373, and miR-17-5p Negatively Regulate the Expression of TBP2 in Lung Cancer. +circulation_biomarker_diagnosis_ns 32425976 hsa-mir-28 Diabetes Mellitus OBJECTIVE: To explore the mechanism of plasma circulating miRNA-126 and miRNA +circulation_biomarker_diagnosis_ns 32425976 hsa-mir-126 Diabetes Mellitus OBJECTIVE: To explore the mechanism of plasma circulating miRNA-126 and miRNA +other 32425721 hsa-mir-520f Melanoma MIR-520f Regulated Itch Expression and Promoted Cell Proliferation in Human Melanoma Cells. +other 32425696 hsa-mir-326 Carcinoma, Hepatocellular SLC27A4 axis participated into the progression of HCC. +genetics_knock down_promote 32425695 hsa-mir-506 Carcinoma, Non-Small-Cell Lung 3p inhibitor or HMGA2 overexpression could reverse the inhibition effect of circ_100565 knockdown on NSCLC progression. +lncRNA target 32425596 hsa-mir-138 Stomach Neoplasms CONCLUSION: circNRIP1 functioned as a miR5p sponge to enhance hypoxia-induced resistance to 5-FU through modulation of HIF-1alpha-dependent glycolysis, which provides a novel potential approach to overcome hypoxia-induced 5-FU resistance in GC. +lncRNA target 32425595 hsa-mir-613 Breast Neoplasms The regulatory role of UCA1 in PTX resistance of BC was achieved by miR-613/CDK12 axis in vivo. CONCLUSION: UCA1 mediated PTX resistance in BC through the miR-613/CDK12 axis, manifesting that UCA1 might improve the PTX treatment of BC as a significant therapeutic biomarker. +genetics_overexpression_promote 32425116 hsa-mir-188 Thyroid Cancer, Papillary 5p overexpression. +genetics_knock down_promote 32425115 hsa-mir-148a Carcinoma, Renal Cell Furthermore, knockdown of FOXK2 reversed the inhibitory effects of miR-148a-3p inhibitor on ccRCC cells. +genetics_GWAS 32424223 hsa-mir-122 Carcinoma, Hepatocellular TERT promoter mutations (C228T and C250T) and miR-122 expression were assessed in the plasma samples from 249 patients with HBV-related liver diseases by nested PCR and qRT-PCR assays, respectively. +lncRNA target 32424142 hsa-mir-182 Breast Neoplasms, Basal Cell Therefore, FOXF2 deficiency accelerates the visceral metastasis of BLBC through unrestricted increases in autocrine and paracrine TGF-beta signaling, and miR +other 32424109 hsa-mir-593 Osteosarcoma MiR3p and ZEB2 were inversely expressed in OS tissues. +lncRNA target 32423991 hsa-mir-641 Cholangiocarcinoma CDR1as and miR-641 could be considered therapeutic targets for CCA. +other 32423818 hsa-mir-625 Leukemia, Myeloid, Acute Moreover, miR-625 levels were dramatically decreased in AML cells when Wnt/beta-catenin signaling was activated. +other 32423796 hsa-mir-29b Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Overall, the miR-29b/29c-3p -TFAP2C-GPX1 axis helped us to have a better understanding of T-ALL pathogenesis. +other 32423796 hsa-mir-29c Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Overall, the miR-29b/29c-3p -TFAP2C-GPX1 axis helped us to have a better understanding of T-ALL pathogenesis. +circulation_biomarker_diagnosis_ns 32423468 hsa-mir-518a Colonic Neoplasms DANCR was found to be sub-localized in cytoplasmic matrix and to mediate murine double minute 2 (MDM2) expression through sponging miR-518a-3p in CC cells, during which the Smad2/3 signaling was activated. CONCLUSION: This study provided evidence that silencing of DANCR might inhibit the growth and metastasis of CC cells through the DANCR/miR-518a-3p/MDM2 ceRNA network and the defect of Smad2/3 while activation of the p53 signaling pathways. +genetics_knock down_suppress 32423405 hsa-mir-223 Pneumonia Finally, overexpression of miR-223 via treatment with miR-223 agomirs attenuated airway inflammation, NLRP3 levels and IL-1beta release. +lncRNA target 32423385 hsa-mir-15b Stomach Neoplasms Moreover, miR-15b targeted DCLK1 to regulate Notch1 expression and inhibited the EMT process in GC cells. +genetics_GWAS 32423237 hsa-mir-10a Carcinoma, Non-Small-Cell Lung Cell proliferation assay showed that overexpression of miR-10a led to increased proliferation rate of NSCLC cells. +other 32423014 hsa-mir-378 Colonic Neoplasms Our study indicated that microRNAs 378b and 378g may play an important role in TiO(2)-NPs-mediated colonic cytotoxicity, which may provide a valuable insight into the molecular mechanisms of potential risks in colitis and colon cancer. +other 32423014 hsa-mir-378b Colonic Neoplasms Our study indicated that microRNAs 378b and 378g may play an important role in TiO(2)-NPs-mediated colonic cytotoxicity, which may provide a valuable insight into the molecular mechanisms of potential risks in colitis and colon cancer. +other 32422901 hsa-mir-4454 Colorectal Neoplasms Our study indicates that the development of miR-4454 as a microRNA-based therapeutic approach to silence GNL3L may remarkably reduce oncogenic cell survival that depends on GNL3L/NF-kappaB signaling, making miR-4454 a candidate for treating metastatic human CRC. +other 32422900 hsa-mir-519d Gestational Trophoblastic Disease Here, we report that miR-519d-3p levels correlate positively with cell proliferation and negatively with migration in trophoblastic cell lines. Transfection of trophoblastic cell lines with miR-519d mimic results in secretion of EVs containing elevated levels of this miRNA (EVmiR-519d). +lncRNA target 32422575 hsa-mir-128 Pancreatic Carcinoma Our data also showed that, in PDAC cells, microRNA-128 regulates and targets PAICS. +lncRNA target 32422563 hsa-mir-499b Urinary Bladder Neoplasms CONCLUSION: DDX11-AS1 exacerbates BLCA progression by enhancing CDK6 expression via suppressing miR-499b-5p. +transcription factor target 32422429 hsa-mir-23b Wounds and Injuries MiR-23b might be a promising target for the treatment of wound healing-associated diseases. +lncRNA target 32422326 hsa-mir-122 Rectal Diseases 5p aggravates radiation-induced rectal injury through targeting CCAR1. +circulation_biomarker_diagnosis_up 32422307 hsa-mir-375 Carcinoma, Hepatocellular SIGNIFICANCE: This study proved that the combined use of serum miR-16 and miR-375 was better than each alone for HCC detection. +circulation_biomarker_diagnosis_up 32422307 hsa-mir-16 Carcinoma, Hepatocellular SIGNIFICANCE: This study proved that the combined use of serum miR-16 and miR-375 was better than each alone for HCC detection. +other 32422306 hsa-mir-466 Myocardial Infarction, Acute In conclusion, Kcnq1ot1 sponged miR-466k and miR-466i-5p to up-regulate Tead1, thus triggering cardiomyocyte injury in the process of AMI. +lncRNA target 32422304 hsa-mir-4749 Glioblastoma 5p targeting RFC2 signaling participates in XN-enhanced TMZ cytotoxicity of GBM. +transcription factor target 32422284 hsa-mir-204 Aniridia Among these miR5p, an inhibitor of corneal neovascularization, was downregulated 26.8-fold in severely vascularized corneas. +other 32421465 hsa-mir-223 Diabetes, Gestational CONCLUSIONS: These findings support the hypothesis of involvement of both miRNA-223 and ANGPTL8 in the pathogenesis of GDM. +genetics_GWAS 32421395 hsa-mir-944 Colorectal Neoplasms In conclusion, miR-944 and EPHA7 are potential genetic markers of CRC predisposition and novel potential non-invasive diagnostic biomarkers for CRC. +other 32420903 hsa-mir-203 Pancreatic Carcinoma Furthermore, PC patients with high miR-10b (HR=1.73, 95%CI=1.09-2.76), miR5p (HR=1.91, 95%CI=1.30-2.80), miR-21 (HR=1.90, 95%CI=1.61-2.25), miR-23a (HR=2.18, 95%CI=1.52-3.13), miR-155 (HR=2.22, 95%CI=1.27-3.88), miR-203 (HR=1.65, 95%CI=1.14-2.40), miR-221 (HR=1.72, 95%CI=1.08-2.74), miR-222 levels (HR=1.72, 95%CI=1.02-2.91) or low miR-29c (HR=1.39, 95%CI=1.08-1.79), miR-126 (HR=1.55, 95%CI=1.23-1.95), miR-218 (HR=2.62, 95%CI=1.41-4.88) levels in tissues had significantly shorter OS (P<0.05). +other 32420903 hsa-mir-221 Pancreatic Carcinoma Furthermore, PC patients with high miR-10b (HR=1.73, 95%CI=1.09-2.76), miR5p (HR=1.91, 95%CI=1.30-2.80), miR-21 (HR=1.90, 95%CI=1.61-2.25), miR-23a (HR=2.18, 95%CI=1.52-3.13), miR-155 (HR=2.22, 95%CI=1.27-3.88), miR-203 (HR=1.65, 95%CI=1.14-2.40), miR-221 (HR=1.72, 95%CI=1.08-2.74), miR-222 levels (HR=1.72, 95%CI=1.02-2.91) or low miR-29c (HR=1.39, 95%CI=1.08-1.79), miR-126 (HR=1.55, 95%CI=1.23-1.95), miR-218 (HR=2.62, 95%CI=1.41-4.88) levels in tissues had significantly shorter OS (P<0.05). +other 32420903 hsa-mir-17 Pancreatic Carcinoma Furthermore, PC patients with high miR-10b (HR=1.73, 95%CI=1.09-2.76), miR5p (HR=1.91, 95%CI=1.30-2.80), miR-21 (HR=1.90, 95%CI=1.61-2.25), miR-23a (HR=2.18, 95%CI=1.52-3.13), miR-155 (HR=2.22, 95%CI=1.27-3.88), miR-203 (HR=1.65, 95%CI=1.14-2.40), miR-221 (HR=1.72, 95%CI=1.08-2.74), miR-222 levels (HR=1.72, 95%CI=1.02-2.91) or low miR-29c (HR=1.39, 95%CI=1.08-1.79), miR-126 (HR=1.55, 95%CI=1.23-1.95), miR-218 (HR=2.62, 95%CI=1.41-4.88) levels in tissues had significantly shorter OS (P<0.05). +other 32420903 hsa-mir-126 Pancreatic Carcinoma Furthermore, PC patients with high miR-10b (HR=1.73, 95%CI=1.09-2.76), miR5p (HR=1.91, 95%CI=1.30-2.80), miR-21 (HR=1.90, 95%CI=1.61-2.25), miR-23a (HR=2.18, 95%CI=1.52-3.13), miR-155 (HR=2.22, 95%CI=1.27-3.88), miR-203 (HR=1.65, 95%CI=1.14-2.40), miR-221 (HR=1.72, 95%CI=1.08-2.74), miR-222 levels (HR=1.72, 95%CI=1.02-2.91) or low miR-29c (HR=1.39, 95%CI=1.08-1.79), miR-126 (HR=1.55, 95%CI=1.23-1.95), miR-218 (HR=2.62, 95%CI=1.41-4.88) levels in tissues had significantly shorter OS (P<0.05). +other 32420903 hsa-mir-29c Pancreatic Carcinoma Furthermore, PC patients with high miR-10b (HR=1.73, 95%CI=1.09-2.76), miR5p (HR=1.91, 95%CI=1.30-2.80), miR-21 (HR=1.90, 95%CI=1.61-2.25), miR-23a (HR=2.18, 95%CI=1.52-3.13), miR-155 (HR=2.22, 95%CI=1.27-3.88), miR-203 (HR=1.65, 95%CI=1.14-2.40), miR-221 (HR=1.72, 95%CI=1.08-2.74), miR-222 levels (HR=1.72, 95%CI=1.02-2.91) or low miR-29c (HR=1.39, 95%CI=1.08-1.79), miR-126 (HR=1.55, 95%CI=1.23-1.95), miR-218 (HR=2.62, 95%CI=1.41-4.88) levels in tissues had significantly shorter OS (P<0.05). +other 32420903 hsa-mir-155 Pancreatic Carcinoma Furthermore, PC patients with high miR-10b (HR=1.73, 95%CI=1.09-2.76), miR5p (HR=1.91, 95%CI=1.30-2.80), miR-21 (HR=1.90, 95%CI=1.61-2.25), miR-23a (HR=2.18, 95%CI=1.52-3.13), miR-155 (HR=2.22, 95%CI=1.27-3.88), miR-203 (HR=1.65, 95%CI=1.14-2.40), miR-221 (HR=1.72, 95%CI=1.08-2.74), miR-222 levels (HR=1.72, 95%CI=1.02-2.91) or low miR-29c (HR=1.39, 95%CI=1.08-1.79), miR-126 (HR=1.55, 95%CI=1.23-1.95), miR-218 (HR=2.62, 95%CI=1.41-4.88) levels in tissues had significantly shorter OS (P<0.05). +other 32420903 hsa-mir-23a Pancreatic Carcinoma Furthermore, PC patients with high miR-10b (HR=1.73, 95%CI=1.09-2.76), miR5p (HR=1.91, 95%CI=1.30-2.80), miR-21 (HR=1.90, 95%CI=1.61-2.25), miR-23a (HR=2.18, 95%CI=1.52-3.13), miR-155 (HR=2.22, 95%CI=1.27-3.88), miR-203 (HR=1.65, 95%CI=1.14-2.40), miR-221 (HR=1.72, 95%CI=1.08-2.74), miR-222 levels (HR=1.72, 95%CI=1.02-2.91) or low miR-29c (HR=1.39, 95%CI=1.08-1.79), miR-126 (HR=1.55, 95%CI=1.23-1.95), miR-218 (HR=2.62, 95%CI=1.41-4.88) levels in tissues had significantly shorter OS (P<0.05). +other 32420903 hsa-mir-222 Pancreatic Carcinoma Furthermore, PC patients with high miR-10b (HR=1.73, 95%CI=1.09-2.76), miR5p (HR=1.91, 95%CI=1.30-2.80), miR-21 (HR=1.90, 95%CI=1.61-2.25), miR-23a (HR=2.18, 95%CI=1.52-3.13), miR-155 (HR=2.22, 95%CI=1.27-3.88), miR-203 (HR=1.65, 95%CI=1.14-2.40), miR-221 (HR=1.72, 95%CI=1.08-2.74), miR-222 levels (HR=1.72, 95%CI=1.02-2.91) or low miR-29c (HR=1.39, 95%CI=1.08-1.79), miR-126 (HR=1.55, 95%CI=1.23-1.95), miR-218 (HR=2.62, 95%CI=1.41-4.88) levels in tissues had significantly shorter OS (P<0.05). +other 32420903 hsa-mir-10b Pancreatic Carcinoma Furthermore, PC patients with high miR-10b (HR=1.73, 95%CI=1.09-2.76), miR5p (HR=1.91, 95%CI=1.30-2.80), miR-21 (HR=1.90, 95%CI=1.61-2.25), miR-23a (HR=2.18, 95%CI=1.52-3.13), miR-155 (HR=2.22, 95%CI=1.27-3.88), miR-203 (HR=1.65, 95%CI=1.14-2.40), miR-221 (HR=1.72, 95%CI=1.08-2.74), miR-222 levels (HR=1.72, 95%CI=1.02-2.91) or low miR-29c (HR=1.39, 95%CI=1.08-1.79), miR-126 (HR=1.55, 95%CI=1.23-1.95), miR-218 (HR=2.62, 95%CI=1.41-4.88) levels in tissues had significantly shorter OS (P<0.05). +other 32420903 hsa-mir-218 Pancreatic Carcinoma Furthermore, PC patients with high miR-10b (HR=1.73, 95%CI=1.09-2.76), miR5p (HR=1.91, 95%CI=1.30-2.80), miR-21 (HR=1.90, 95%CI=1.61-2.25), miR-23a (HR=2.18, 95%CI=1.52-3.13), miR-155 (HR=2.22, 95%CI=1.27-3.88), miR-203 (HR=1.65, 95%CI=1.14-2.40), miR-221 (HR=1.72, 95%CI=1.08-2.74), miR-222 levels (HR=1.72, 95%CI=1.02-2.91) or low miR-29c (HR=1.39, 95%CI=1.08-1.79), miR-126 (HR=1.55, 95%CI=1.23-1.95), miR-218 (HR=2.62, 95%CI=1.41-4.88) levels in tissues had significantly shorter OS (P<0.05). +transcription factor target 32420902 hsa-mir-144 Osteoarthritis Our evidence is the first to show that APLN stimulates the expression of IL-1beta by activating the PI3K and ERK pathway and suppressing downstream expression of miRNA3p in OASFs. +lncRNA target 32420810 hsa-mir-584 Carcinoma, Non-Small-Cell Lung Silencing of circABCB10 suppressed non-small cell lung cancer cell migration, cell proliferation, and invasion.CircABCB10 can act as a sponge of miR +genetics_overexpression_promote 32420808 hsa-mir-494 Glioma Further study proved that the overexpression of miRNA +lncRNA target 32420798 hsa-mir-5195 Carcinoma, Hepatocellular Subsequently, it confirmed that HOXB6 was target gene of miR +lncRNA target 32420678 hsa-mir-340 Breast Neoplasms 3p/YWHAZ axis and activating the canonical Wnt/beta-catenin signaling pathway, indicating that H19 might act as an underlying therapeutic target and prognostic biomarker for BC therapy. +other 32420596 hsa-mir-192 Celiac Disease The random forest algorithm identified a signature of 38 classifier miRNAs, among which, the miR-200 and miR-192/215 families were progressively lost in RCD2 and ITL-CD, whereas miR-17/92 and C19MC miRNAs were up-regulated. +other 32420596 hsa-mir-200 Celiac Disease The random forest algorithm identified a signature of 38 classifier miRNAs, among which, the miR-200 and miR-192/215 families were progressively lost in RCD2 and ITL-CD, whereas miR-17/92 and C19MC miRNAs were up-regulated. +other 32420596 hsa-mir-17 Celiac Disease The c-MYC regulated miR-17/92 cluster distinguishes monomorphic epitheliotropic ITL (MEITL) from EATL and prognosticates EATL outcome. +lncRNA target 32420340 hsa-mir-6088 Glioma Transfection of miR-6088 mimic or si-SMARCB1 could obviously reverse the favorable effect of pcDNA3.1-MEG3 on glioma progression. CONCLUSION: Collectively, the evidence in this study indicated that MEG3 was downregulated in glioma cells and inhibited proliferation and migration of glioma cells via regulating miR-6088/SMARCB1 axis. +genetics_overexpression_suppress 32420320 hsa-mir-22 Carcinoma, Non-Small-Cell Lung Furthermore, the inhibitory effect of miR-22 can be reversed via overexpressing NET1 using an ectopic expression vector in NSCLC cells. +genetics_overexpression_promote 32420217 hsa-mir-145 Uveal melanoma Significant growth and invasion inhibitory effects were observed in human UM cells with miRNA-145 and miRNA-205 overexpression. +genetics_overexpression_promote 32420217 hsa-mir-205 Uveal melanoma Significant growth and invasion inhibitory effects were observed in human UM cells with miRNA-145 and miRNA-205 overexpression. +other 32419983 hsa-mir-449b Ovarian Neoplasms Conclusion We defined several prognostic biomarkers for the incidence and progression of HGSOC and constructed a network for ceRNA axes; among which three were indicated to have a positive correlation with lymphocyte infiltration, namely: FTX-hsa-miR5p-STK11, LINC00665-hsa-miR449b-5p-VAV3 and LINC00665-hsa-miR449b-5p-RRAGD. +other 32419983 hsa-mir-150 Ovarian Neoplasms Conclusion We defined several prognostic biomarkers for the incidence and progression of HGSOC and constructed a network for ceRNA axes; among which three were indicated to have a positive correlation with lymphocyte infiltration, namely: FTX-hsa-miR5p-STK11, LINC00665-hsa-miR449b-5p-VAV3 and LINC00665-hsa-miR449b-5p-RRAGD. +lncRNA target 32419651 hsa-mir-196 Stomach Neoplasms CONCLUSIONS: These results suggested that microRNA-3196 might not only a tumor suppressor in gastric cancer cells by modulating OTX1 but also might be an independent prognostic biomarker and therapeutic target of gastric cancer. +lncRNA target 32419643 hsa-mir-494 Glioma Targeting of WT1-AS, miR +lncRNA target 32419118 hsa-mir-27b Esophageal Squamous Cell Carcinoma Taken together, the newly identified miR-27b-3p/Nrf2 axis might represent a new candidate therapeutic target for ESCC treatment. +circulation_biomarker_diagnosis_ns 32419112 hsa-mir-1976 Breast Neoplasms RESULTS: The expression levels of miR-1976 in plasma samples were found significantly lower in patients with BC than those in healthy controls, and were associated with Ki-67. +circulation_biomarker_diagnosis_down 32418991 hsa-mir-622 Breast Neoplasms RESULTS: miR-622 is downregulated in plasma and in tissues of breast cancer patients respect to healthy controls and its downregulation is significantly associated with advanced grade and high Ki67 level. +circulation_biomarker_diagnosis_ns 32418910 hsa-mir-423 Testicular Diseases 3p in serum exosomes as noninvasive biomarkers for testicular injury in rats. +circulation_biomarker_diagnosis_ns 32418910 hsa-mir-128 Testicular Diseases 3p in serum exosomes as noninvasive biomarkers for testicular injury in rats. +genetics_overexpression_promote 32418767 hsa-mir-95 Colorectal Neoplasms The overexpression of miR +genetics_overexpression_promote 32418155 hsa-mir-29b Glioblastoma In GBM cells, overexpression of DCST1-AS1 resulted in the downregulation of miR-29b and the increased methylation level of miR-29b gene. +genetics_knock down_promote 32418060 hsa-mir-532 Diabetes Mellitus Therefore, miR-532 may serve as a promising therapeutic agent to overcome the diabetes-induced loss of cardiomyocytes. +lncRNA target 32417959 hsa-mir-504 Uterine Cervical Neoplasms CONCLUSION: Our observations elucidated that miR-504, acting as a suppressor for the progression of cervical cancer, inhibits cell proliferation, invasion and migration, and mediates EMT via negatively regulating PAICS. +lncRNA target 32417918 hsa-mir-125b Medulloblastoma Increased expression of miR-181a-5p, miR-125b-5p, and let-7b-5p was further confirmed in Group 3 MB cells with real-time PCR and was shown to increase in vitro invasion and migratory abilities of tumor cells through the activation of ERK in Ras/MAPK pathway. +lncRNA target 32417918 hsa-mir-181a Medulloblastoma Increased expression of miR-181a-5p, miR-125b-5p, and let-7b-5p was further confirmed in Group 3 MB cells with real-time PCR and was shown to increase in vitro invasion and migratory abilities of tumor cells through the activation of ERK in Ras/MAPK pathway. +lncRNA target 32417918 hsa-let-7b Medulloblastoma Increased expression of miR-181a-5p, miR-125b-5p, and let-7b-5p was further confirmed in Group 3 MB cells with real-time PCR and was shown to increase in vitro invasion and migratory abilities of tumor cells through the activation of ERK in Ras/MAPK pathway. +other 32417880 hsa-mir-143 Cervical Intraepithelial Neoplasia 3p, a subpanel of the original six miRNAs. +other 32417880 hsa-mir-191 Cervical Intraepithelial Neoplasia 3p, a subpanel of the original six miRNAs. +other 32417880 hsa-mir-26b Cervical Intraepithelial Neoplasia 3p, a subpanel of the original six miRNAs. +genetics_knock down_suppress 32417846 hsa-mir-214 Ovarian Neoplasms CONCLUSIONS We are the first to report that knockdown of DANCR could affect the biological process of ovarian cancer cells treated with TGF-ss by sponging miR-214, which may provide new therapeutic ideas of ovarian cancer. +other 32417803 hsa-mir-210 Ischemic Stroke Immunofluorescence staining and RT-qPCR were used to detect the expression changes of miRNA-210 and ephrinA3 in the ischemic cortex after ischemia. +genetics_overexpression_promote 32417760 hsa-mir-200c Skin Neoplasms MiR-200c-3p overexpression inhibited the EMT process in EGFR TKI resistance cell lines and promoted cell death. +lncRNA target 32417760 hsa-mir-203a Skin Neoplasms RESULTS: We identified miR-200c-3p and miR-203a-3p as potential EGFR TKI resistance regulators via their modulation of epithelial-to-mesenchymal transition (EMT). +transcription factor target 32417721 hsa-mir-150 Carcinoma, Hepatocellular The up-regulation of miR5p induced by AS-IV suppressed the progression of HCC by repressing beta-catenin, providing a new molecular target for the utilization of AS-IV In the treatment of HCC. +circulation_biomarker_diagnosis_ns 32417393 hsa-mir-155 Kidney Calculi The expression levels of miR-155 in serum and renal tissues were quantified in 20 patients with nephrolithiasis using qRT-PCR assay. +genetics_overexpression_promote 32417375 hsa-mir-223 Inflammation NLRP3 was the downstream target of microRNA-223, the overexpression of which led to severe inflammation in microglia. +genetics_overexpression_promote 32417375 hsa-mir-223 Spinal Cord Injuries NLRP3 was the downstream target of microRNA-223, the overexpression of which led to severe inflammation in microglia. +genetics_knock down_suppress 32417187 hsa-mir-621 Stomach Neoplasms SYF2 overexpression was similar to that induced by miR-621 loss in gastric cancer. +other 32416791 hsa-mir-375 Body Weight The level of miR-375 was not different between WB and NB muscles. +other 32416791 hsa-mir-375 Nijmegen Breakage Syndrome The level of miR-375 was not different between WB and NB muscles. +circulation_biomarker_diagnosis_up 32416702 hsa-mir-372 Carcinoma, Hepatocellular 3p in the blood of the responder group of HCC patients who received TACE with Dox than of non-responders. +other 32416187 hsa-mir-29a Colonic Neoplasms Here, the functional effects of miR-29a in chemo-resistant colon cancer cells is scrutinized. MiR-29a might proffer a novel promising candidate for colon cancer therapeutics during chemotherapy. +lncRNA target 32416102 hsa-mir-103a Glioma Mechanistically, we identified that TP73-AS1 in glioma acts as a ceRNA by sequestering miR-103a from GALNT7. Altogether, our results established that TP73-AS1 facilitates the progression of glioma through competing for endogenous RNA (ceRNA) in a TP73-AS1/miR-103a/GALNT7 loop. +lncRNA target 32415942 hsa-mir-124 Epilepsy This research aimed to investigate the effect of miR-124 on the PI3K/Akt signaling pathway in refractory epilepsy rats. In conclusion, miR-124 can play a protective role in temporal lobe epilepsy by promoting PI3K/Akt signaling pathway, including the protection of cognitive function, which may be a potential target for clinical treatment of intractable epilepsy in the future. +other 32415933 hsa-mir-146a Acute Kidney Injury In conclusion, DEX can improve oxidative stress and inflammatory responses in rats with SAKI, reduce the severity of the renal injury, and up-regulate the expression level of miR-146a. +other 32415933 hsa-mir-146a Sepsis In conclusion, DEX can improve oxidative stress and inflammatory responses in rats with SAKI, reduce the severity of the renal injury, and up-regulate the expression level of miR-146a. +other 32415927 hsa-mir-17 Dermatitis 5p), 31 transcription factors (including AhR, Foxo1 and Sp1) and 10 endogenous genes (including Il5, Atp5d, and Cox4i1). +other 32415927 hsa-mir-122 Dermatitis 5p), 31 transcription factors (including AhR, Foxo1 and Sp1) and 10 endogenous genes (including Il5, Atp5d, and Cox4i1). +other 32415927 hsa-mir-122 Burns 5p), 31 transcription factors (including AhR, Foxo1 and Sp1) and 10 endogenous genes (including Il5, Atp5d, and Cox4i1). +other 32415927 hsa-mir-17 Burns 5p), 31 transcription factors (including AhR, Foxo1 and Sp1) and 10 endogenous genes (including Il5, Atp5d, and Cox4i1). +circulation_biomarker_prognosis_up 32415925 hsa-mir-93 Esophageal Neoplasms 5p in serum, esophageal carcinoma patients were divided into high expression and low expression groups. +other 32415722 hsa-mir-155 Adenocarcinoma, Follicular 5p may be an independent prognostic factor for thyroid follicular carcinoma associated with cell apoptosis. +lncRNA target 32415512 hsa-mir-579 Diabetes Mellitus (Proc Natl Acad Sci USA 116:7455-7464, 2019) shown that a novel diabetic retinopathy (DR)-associated CircRNA cPWWP2A, which could act as a competing endogenous RNA interacting with miR-579 to promote the DR-induced retinal vascular dysfunction through up-regulating the expression of Angiopoietin 1, Occludin, and SIRT1. +transcription factor target 32415511 hsa-mir-215 Adenocarcinoma of Lung 5p could target the highest number of LA-related genes. +transcription factor target 32415511 hsa-mir-192 Adenocarcinoma of Lung 5p could target the highest number of LA-related genes. +lncRNA target 32415262 hsa-let-7b Arthritis, Rheumatoid Hence, the effectiveness of IRAK4i was compared with that of a TNF inhibitor (i) or anti-IL-6R treatment in collagen-induced arthritis (CIA) and miR-Let7b-mediated arthritis. +other 32415208 hsa-mir-142 Triple Negative Breast Neoplasms Notably, higher LOX, ITGA5, or FN1, or lower miR3p levels are associated with shorter survival in chemotherapy-treated TNBC patients. +transcription factor target 32415058 hsa-mir-29c Infertility, Female These RNA molecules, such as miR-29c and lnc-SDNOR, represent potential targets for treatment of reproductive diseases and improvement of female fertility. +transcription factor target 32415058 hsa-mir-29c Genital Diseases, Female These RNA molecules, such as miR-29c and lnc-SDNOR, represent potential targets for treatment of reproductive diseases and improvement of female fertility. +other 32415054 hsa-mir-760 Prostatic Neoplasms Our study reveals that androgen downregulates miR-760 to promote the growth of PCa cells by regulating IL6. +genetics_knock down_promote 32414769 hsa-mir-370 Sepsis Knockdown of NEAT1 hampered sepsis progression by downregulating Irak2 via interacting with miR +genetics_overexpression_promote 32414422 hsa-mir-490 Carcinoma, Ovarian Epithelial Instead, overexpression of TONSL-AS1 resulted in the upregulation of CDK1, a target of miR +circulation_biomarker_diagnosis_ns 32414413 hsa-mir-15b Alzheimer Disease CONCLUSION: Blood miR-146b-5p and miR15b-5p showed consistent differential expression in AD compared to controls. +circulation_biomarker_diagnosis_ns 32414413 hsa-mir-146b Alzheimer Disease CONCLUSION: Blood miR-146b-5p and miR15b-5p showed consistent differential expression in AD compared to controls. +other 32414303 hsa-mir-150 Coronary Artery Disease beta-blocker and diabetic medication usage significantly modified the correlation between O(3) exposure and miR-150 expression where the link was more prominent among non-users. +lncRNA target 32414231 hsa-mir-1271 Ovarian Neoplasms 5p inhibited the tumorigenesis of OC through targeting E2F5 and negatively regulated the mTOR signaling pathway. +other 32414226 hsa-mir-379 Myocardial Infarction, Acute Finally, miR-379 agomir was used to inject the tail vein of AMI rats and verified the protective effect of miR-379 in the heart in vivo. +other 32414226 hsa-mir-379 Cardiomyopathies Finally, miR-379 agomir was used to inject the tail vein of AMI rats and verified the protective effect of miR-379 in the heart in vivo. +other 32414208 hsa-mir-200a Triple Negative Breast Neoplasms Functional Link between miR-200a and ELK3 Regulates the Metastatic Nature of Breast Cancer. +epigenetics 32413978 hsa-mir-21 Pituitary Neoplasms DNA methylation and expression levels of three of them (MIR145, MIR21, and MIR184) were determined in the independent group of 80 tumors with pyrosequencing and qRT-PCR and results confirmed both aberrant methylation in PitNETs and correlation between methylation and expression. +epigenetics 32413978 hsa-mir-145 Pituitary Neoplasms DNA methylation and expression levels of three of them (MIR145, MIR21, and MIR184) were determined in the independent group of 80 tumors with pyrosequencing and qRT-PCR and results confirmed both aberrant methylation in PitNETs and correlation between methylation and expression. +epigenetics 32413978 hsa-mir-184 Pituitary Neoplasms DNA methylation and expression levels of three of them (MIR145, MIR21, and MIR184) were determined in the independent group of 80 tumors with pyrosequencing and qRT-PCR and results confirmed both aberrant methylation in PitNETs and correlation between methylation and expression. +genetics_overexpression_promote 32413870 hsa-mir-214 Colorectal Neoplasms 3p and overexpression of downstream PLAGL2 in CRC indicated a poor prognosis. +genetics_overexpression_promote 32413869 hsa-mir-142 Non-alcoholic Fatty Liver Disease Taken together, overexpression of miR +lncRNA target 32413855 hsa-mir-24 Cerebral Hemorrhage CONCLUSIONS The present study suggests that thrombin reduces HIF-1 degradation and initiates angiogenesis by increasing miR-24, which targets PHD1 after ICH. +lncRNA target 32413855 hsa-mir-24-1 Cerebral Hemorrhage CONCLUSIONS The present study suggests that thrombin reduces HIF-1 degradation and initiates angiogenesis by increasing miR-24, which targets PHD1 after ICH. +genetics_overexpression_promote 32413671 hsa-mir-429 Carcinoma, Renal Cell Collectively, miR-429 deficiency negatively correlated with CRKL overexpression promoted the aggressiveness of cancer cells and advanced the clinical progression of ccRCC patients. +lncRNA target 32413396 hsa-mir-124 Spinal Cord Injuries The miRNA miR-124 has been reported to be a promising target for the repair of spinal cord injury (SCI), which is a devastating neurological condition. +lncRNA target 32413360 hsa-mir-494 Hypospadias CONCLUSIONS: The study indicates that downregulation of miR-494 inhibits the TGF-beta1/Smads signaling pathway and prevents the development of hypospadias through upregulating Nedd4L. +other 32413244 hsa-mir-24 Encephalocele After transfecting ADMSCs with an MSNs-PEI-miR-24 agomir or antagomir and loading the cells onto gelatin-chitosan scaffolds, the compounds were assessed for their abilities to repair the critical-sized calvarial defects in rats. +other 32413192 hsa-mir-613 Non-alcoholic Fatty Liver Disease In conclusion, CCAT1 increases LXRalpha transcription by serving as a competing endogenous RNA for miR-613 in an LXRE-dependent manner, thereby promoting lipid droplet formation and NAFLD. +transcription factor target 32413114 hsa-mir-20a Acute Liver Injury Our findings suggest that mangiferin alleviates ER stress in acute liver injury by regulating the miR-20a/miR-101a-Nrf2 axis. +transcription factor target 32413114 hsa-mir-101a Acute Liver Injury Our findings suggest that mangiferin alleviates ER stress in acute liver injury by regulating the miR-20a/miR-101a-Nrf2 axis. +genetics_overexpression_promote 32412911 hsa-mir-196a Esophageal Squamous Cell Carcinoma Overexpression showed that miR-196a-5p increased, whereas miR +genetics_overexpression_promote 32412911 hsa-mir-1 Esophageal Squamous Cell Carcinoma Overexpression showed that miR-196a-5p increased, whereas miR +lncRNA target 32412861 hsa-mir-155 Cerebral Hemorrhage Furthermore, inhibition of miR-155 led to improvement of neurological deficits in ICH rats. +genetics_GWAS 32412799 hsa-mir-499 Oligospermia Aims: The present study was designed to survey the associations between polymorphisms of the common single nucleotide polymorphism (SNP) rs4938723 in the miR-34b/c gene, as well as the rs3746444 SNP in the miR-499 gene, and impairment of spermatogenesis leading to oligospermia and azoospermia in the Chinese population. +genetics_GWAS 32412799 hsa-mir-499 Infertility, Male Aims: The present study was designed to survey the associations between polymorphisms of the common single nucleotide polymorphism (SNP) rs4938723 in the miR-34b/c gene, as well as the rs3746444 SNP in the miR-499 gene, and impairment of spermatogenesis leading to oligospermia and azoospermia in the Chinese population. +genetics_GWAS 32412799 hsa-mir-34b Infertility, Male Aims: The present study was designed to survey the associations between polymorphisms of the common single nucleotide polymorphism (SNP) rs4938723 in the miR-34b/c gene, as well as the rs3746444 SNP in the miR-499 gene, and impairment of spermatogenesis leading to oligospermia and azoospermia in the Chinese population. Conclusion: The CC genotype of the rs4938723 locus in the miR-34b/c gene may enhance susceptibility to oligospermia. +genetics_GWAS 32412799 hsa-mir-34c Infertility, Male Aims: The present study was designed to survey the associations between polymorphisms of the common single nucleotide polymorphism (SNP) rs4938723 in the miR-34b/c gene, as well as the rs3746444 SNP in the miR-499 gene, and impairment of spermatogenesis leading to oligospermia and azoospermia in the Chinese population. Conclusion: The CC genotype of the rs4938723 locus in the miR-34b/c gene may enhance susceptibility to oligospermia. +genetics_GWAS 32412799 hsa-mir-499 Azoospermia Aims: The present study was designed to survey the associations between polymorphisms of the common single nucleotide polymorphism (SNP) rs4938723 in the miR-34b/c gene, as well as the rs3746444 SNP in the miR-499 gene, and impairment of spermatogenesis leading to oligospermia and azoospermia in the Chinese population. +genetics_GWAS 32412799 hsa-mir-34c Oligospermia Aims: The present study was designed to survey the associations between polymorphisms of the common single nucleotide polymorphism (SNP) rs4938723 in the miR-34b/c gene, as well as the rs3746444 SNP in the miR-499 gene, and impairment of spermatogenesis leading to oligospermia and azoospermia in the Chinese population. Conclusion: The CC genotype of the rs4938723 locus in the miR-34b/c gene may enhance susceptibility to oligospermia. +genetics_GWAS 32412799 hsa-mir-34b Oligospermia Aims: The present study was designed to survey the associations between polymorphisms of the common single nucleotide polymorphism (SNP) rs4938723 in the miR-34b/c gene, as well as the rs3746444 SNP in the miR-499 gene, and impairment of spermatogenesis leading to oligospermia and azoospermia in the Chinese population. Conclusion: The CC genotype of the rs4938723 locus in the miR-34b/c gene may enhance susceptibility to oligospermia. +genetics_GWAS 32412799 hsa-mir-34c Azoospermia Aims: The present study was designed to survey the associations between polymorphisms of the common single nucleotide polymorphism (SNP) rs4938723 in the miR-34b/c gene, as well as the rs3746444 SNP in the miR-499 gene, and impairment of spermatogenesis leading to oligospermia and azoospermia in the Chinese population. Conclusion: The CC genotype of the rs4938723 locus in the miR-34b/c gene may enhance susceptibility to oligospermia. +genetics_GWAS 32412799 hsa-mir-34b Azoospermia Aims: The present study was designed to survey the associations between polymorphisms of the common single nucleotide polymorphism (SNP) rs4938723 in the miR-34b/c gene, as well as the rs3746444 SNP in the miR-499 gene, and impairment of spermatogenesis leading to oligospermia and azoospermia in the Chinese population. Conclusion: The CC genotype of the rs4938723 locus in the miR-34b/c gene may enhance susceptibility to oligospermia. +other 32412793 hsa-mir-1 Endometrial Neoplasms 3p. +other 32412786 hsa-mir-21 Leukemia, Myeloid, Acute Conclusion: TP73-AS1 may regulate the miR-21/PTEN axis to affect cell proliferation in AML. +lncRNA target 32412777 hsa-mir-2355 Urinary Bladder Neoplasms 5p was validated to be able to bind with DDX11-AS1 and inhibit cell proliferation in BC. +genetics_knock down_suppress 32412771 hsa-mir-145 Carcinoma, Non-Small-Cell Lung 5p or SOX2 knockdown repressed the proliferation, migration, invasion, and attenuated PTX resistance in PTX-resistant BC cells. +genetics_knock down_suppress 32412771 hsa-mir-145 Breast Neoplasms 5p or SOX2 knockdown repressed the proliferation, migration, invasion, and attenuated PTX resistance in PTX-resistant BC cells. +genetics_overexpression_suppress 32412676 hsa-mir-140 Osteosarcoma Furthermore, hindering PGM5-AS1 and FBN1 or overexpressing miR +circulation_biomarker_diagnosis_up 32412315 hsa-mir-145 Diabetes Mellitus The plasma level of miR +circulation_biomarker_diagnosis_ns 32412065 hsa-mir-574 Bronchopulmonary Dysplasia The blood samples of BPD infants were detected by real-time q-PCR and found that the expression of miRNA +other 32412059 hsa-mir-22 Sepsis 3p induced protective role in sepsis-induced acute kidney injury may rely on the repression of PTEN. +other 32412059 hsa-mir-22 Acute Kidney Injury 3p induced protective role in sepsis-induced acute kidney injury may rely on the repression of PTEN. +lncRNA target 32412057 hsa-mir-375 Pre-Eclampsia PURPOSE To study the mechanism of vascular endothelial growth factor (VEGF) regulated by miR-375 and Sonic hedgehog (SHH) signaling pathways on the characteristics of trophoblast cells (TCs) in preeclampsia (PE) rats. CONCLUSIONS Over-expressing miR-375 can inhibit the expression of VEGF, thus slow down the invasion and proliferation of TCS in PE rats, which is realized by regulating SHH signal pathway. +lncRNA target 32412051 hsa-mir-542 Neuroblastoma 3p/HNF4alpha axis modified NB progression via RAS/RAF/MEK/ERK signaling pathway, might highlight a novel therapeutic approach for NB. +other 32411934 hsa-mir-210 Lupus Erythematosus, Systemic The aim of the study is to examine the regulation of miR-21 and mir-210 in patients with SLE based on the hypothesis that cellular hypoxia may have an important role in SLE pathogenesis. The study will provide novel data regarding the expression and the role of miR-21 and miR-210 in patients with SLE. +other 32411934 hsa-mir-21 Lupus Erythematosus, Systemic The aim of the study is to examine the regulation of miR-21 and mir-210 in patients with SLE based on the hypothesis that cellular hypoxia may have an important role in SLE pathogenesis. The study will provide novel data regarding the expression and the role of miR-21 and miR-210 in patients with SLE. +lncRNA target 32411796 hsa-mir-24 Adenocarcinoma of Lung Targeting the miR +genetics_overexpression_promote 32411707 hsa-mir-381 Carcinoma, Renal Cell 3p overexpression promotes colony formation in human renal cancer cells. +transcription factor target 32411568 hsa-mir-429 Diabetes Mellitus, Type 2 Our study suggests that Dex alleviates CICI by modulating miR3p expression in rats. +other 32411519 hsa-mir-106b Carcinoma, Hepatocellular are identified as good classifiers of HCC. +other 32411519 hsa-mir-195 Carcinoma, Hepatocellular are identified as good classifiers of HCC. +transcription factor target 32411123 hsa-mir-126 Sepsis The data suggest that HSPA12B protects against sepsis-induced severe cardiomyopathy via regulating miR-126 expression which targets adhesion molecules, thus decreasing the accumulation of immune cells in the myocardium. +lncRNA target 32411077 hsa-mir-155 Glioma Conclusion: The study indicated that miR-155 take charge a key function in regulating the proliferation, migration, and invasion of glioma U87-MG cells through PI3K/AKT signaling pathway, and has anti-glioma effects by inhibition of miR-155, which provided ideas for further clinical treatment of glioma patients. +other 32410883 hsa-mir-27a Multiple Myeloma CONCLUSION: OIP5-AS1 repressed multiple myeloma progression by regulating miR-27a-3p/TSC1 axis. +other 32410870 hsa-mir-125b Pneumonia In particular, the four most significantly upregulated miRNAs in children with severe RSV-associated pneumonia were hsa-miR5p, hsa-miR-10a-3p, hsa-miR-125b-5p, and hsa-miR-30b-3p. +other 32410870 hsa-mir-1271 Pneumonia In particular, the four most significantly upregulated miRNAs in children with severe RSV-associated pneumonia were hsa-miR5p, hsa-miR-10a-3p, hsa-miR-125b-5p, and hsa-miR-30b-3p. +other 32410870 hsa-mir-10a Pneumonia In particular, the four most significantly upregulated miRNAs in children with severe RSV-associated pneumonia were hsa-miR5p, hsa-miR-10a-3p, hsa-miR-125b-5p, and hsa-miR-30b-3p. +genetics_overexpression_suppress 32410866 hsa-mir-129 Sepsis Then, MEG3 was overexpressed, and we found that its overexpression repressed the intestinal injury via downregulating miR +genetics_overexpression_suppress 32410866 hsa-mir-129 Intestinal Diseases Then, MEG3 was overexpressed, and we found that its overexpression repressed the intestinal injury via downregulating miR +lncRNA target 32410838 hsa-mir-29b Tendinopathy Conclusion: We conclude that the use of miR-29b inhibitor at the end of the tendon break could initiate endogenous repair mechanism and subsequently use of TSA should be able to inhibit the exogenous repair mechanism. +genetics_overexpression_promote 32410663 hsa-mir-193a Medulloblastoma Therefore, miR-193a has therapeutic potential in the treatment of not only Group 3 medulloblastomas but possibly other MYC overexpressing aggressive cancers as well. +lncRNA target 32410637 hsa-mir-596 Femur Head Necrosis BACKGROUND: It is reported that miR-596 has a potential diagnostic value for non-traumatic osteonecrosis of the femoral head (NOFH), but its underlying mechanisms in NOFH is unclear. RESULTS: MiR-596 expression was upregulated, while Smad3 expression was inhibited in the bone marrow samples of patients with steroid-induced osteonecrosis of femoral head (SANFH). +lncRNA target 32410584 hsa-mir-20a Gastrointestinal Neoplasms Ultimately, the crucial targets and modules were identified by constructing the protein-protein interaction network of miR-20a targets, which were highly associated with the initiation and progression of GIC according to previous molecular biology experiments. +circulation_biomarker_diagnosis_ns 32410577 hsa-mir-214 Carotid Stenosis CONCLUSION: Our findings suggested that miR-214 plays a role in the modulation of VSMC angiogenesis, proliferation, and senescence with its plasma level being increased in CAS patients with elevated LDL-C value, implying that it may be a vascular senescence marker and a potential therapeutic target for vascular diseases. +genetics_overexpression_promote 32410569 hsa-mir-543 Carcinoma, Non-Small-Cell Lung Further studies showed that inhibition of MTA1 weakened the role of miR-543 overexpression in NSCLC cells. +genetics_overexpression_suppress 32410348 hsa-mir-126 Breast Neoplasms In conclusion, the above findings demonstrated that overexpression of miR-126 or down-regulation of its target gene may be a potential approach to overcome trastuzumab resistance in breast cancer cells. +other 32410261 hsa-mir-23 Osteoporosis MATERIALS: The expression of miR-23 and MEF2C was measured in osteoporosis (OP) patients and healthy controls by a quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR). +other 32410261 hsa-mir-23 Osteoporosis-pseudoglioma syndrome MATERIALS: The expression of miR-23 and MEF2C was measured in osteoporosis (OP) patients and healthy controls by a quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR). RESULTS: miR-23 is found to be up-regulated and MEF2C is down-regulated in OP patients compared to healthy controls. +other 32410228 hsa-mir-361 Hypertension The ceRNA correlations among lnc-OTX1-7:1, hsa-miR5p and GIMAP8 were confirmed in SSH and SRH patients. +lncRNA target 32410140 hsa-mir-125a Carcinoma, Hepatocellular In this study, Zbtb7a was found to suppress the expression of miR-125a, an oncosuppressive miRNA that is often downregulated in HCC. Consistent with this observation, the analysis of 370 HCC samples showed an upregulation of Zbtb7a compared to 50 normal liver tissues and a reverse correlation with miR-125a expression. +lncRNA target 32409958 hsa-mir-1224 Ovarian Neoplasms 5p inhibited the expression of mesenchymal markers and increased the expression of epithelial markers in ovarian cancer cells via targeting SND1, indicating miR +lncRNA target 32409849 hsa-mir-637 Carcinoma, Renal Cell Moreover, bioinformatic analysis and luciferase reporter assay showed that circHIPK3 targeted miR-637 in CCRCC cells. Hence, CircHIPK3 may represent a tumor suppressor and target miR-637 in clear cell renal carcinoma. +genetics_knock down_promote 32409840 hsa-mir-487a Osteosarcoma Knockdown of miR-487a suppressed OS cell growth and invasion and induced apoptosis; however, overexpression of miR-487a promoted OS cell growth and invasion. +other 32409593 hsa-mir-21 Carcinoma, Pancreatic Ductal Thus, miR-21 may be useful for early PanIN detection, and for intercepting developing premalignant pancreatic lesions and other KRAS-driven premalignancies. +transcription factor target 32409283 hsa-mir-126 Liver Neoplasms 5p was aberrantly decreased in HCC and subsequently relieved the suppression on EGFR expression, which consequently contributed to the tumor biology of HCC. +genetics_knock down_promote 32408908 hsa-mir-152 Breast Neoplasms MiR-152 inhibition or ZEB1 overexpression abolished the impacts of circKIF4A knockdown on cell migration, invasion and apoptosis in BC. +lncRNA target 32408786 hsa-mir-218 Hyperglycemia While downregulating miR-218 showed the opposite results.Conclusion: These data demonstrated that, under an in vitro HG environment, miR-218 suppressed the HK-2 cells proliferation, promoted apoptosis, caused an inflammatory response, and facilitated the EMT process largely by targeting DACH1, providing an insight into the therapeutic intervention of DKD. +other 32408786 hsa-mir-218 Diabetic Nephropathies Objective: This report was designed to assess the functional role of miR-218/dachshund family transcription factor 1 (DACH1) in diabetic kidney disease (DKD) and investigate its possible molecular mechanism.Materials and Methods: From the GEO database, we downloaded different datasets for analyzing the expression of miR-218 and DACH1 in DKD. +lncRNA target 32408786 hsa-mir-218 dystonia 5 While downregulating miR-218 showed the opposite results.Conclusion: These data demonstrated that, under an in vitro HG environment, miR-218 suppressed the HK-2 cells proliferation, promoted apoptosis, caused an inflammatory response, and facilitated the EMT process largely by targeting DACH1, providing an insight into the therapeutic intervention of DKD. +circulation_biomarker_diagnosis_ns 32408759 hsa-mir-4260 Cleft Palate, Non-Syndromic Hsa-miR-4260 expression decreased in the serum of CLO. +genetics_knock down_suppress 32408404 hsa-mir-137 Mental Disorders These data suggest that KCC2 antagonists or knockdown might be beneficial to neuropsychiatric disorders due to the deficiency of miR-137. +other 32408404 hsa-mir-137 Child Development Disorders, Pervasive MIR137 has been previously identified as a risk gene for the etiology of schizophrenia, bipolar disorder, and autism spectrum disorder. +other 32408404 hsa-mir-137 Schizophrenia MIR137 has been previously identified as a risk gene for the etiology of schizophrenia, bipolar disorder, and autism spectrum disorder. +other 32408404 hsa-mir-137 Bipolar Disorder MIR137 has been previously identified as a risk gene for the etiology of schizophrenia, bipolar disorder, and autism spectrum disorder. +lncRNA target 32408377 hsa-mir-181d Carcinoma, Renal Cell The human microRNA (miR) OneArray showed that miR-181d and miR-let-7f were induced by melatonin and, respectively, targeted the 3'-UTR and non-3'-UTR of ADAMTS1 to suppress its expression and mRCC invasive ability. Clinically, RCC patients with high levels of miR-181d or miR-let-7f and a low level of ADAMTS1 had the most favorable prognoses. +lncRNA target 32408377 hsa-let-7f Carcinoma, Renal Cell The human microRNA (miR) OneArray showed that miR-181d and miR-let-7f were induced by melatonin and, respectively, targeted the 3'-UTR and non-3'-UTR of ADAMTS1 to suppress its expression and mRCC invasive ability. Clinically, RCC patients with high levels of miR-181d or miR-let-7f and a low level of ADAMTS1 had the most favorable prognoses. +other 32408351 hsa-mir-3687 Prostatic Neoplasms, Castration-Resistant RESULTS: Levels of 2 miRNAs, miR-375 and miR-3687, and 1 lncRNA, N-acetylated alpha-linked acidic dipeptidase like 2 antisense RNA 2 (NAALADL2-AS2), were more than 2-fold higher in patients with mCRPC compared with healthy volunteers. CONCLUSIONS: We identified miR-3687 as a novel prognostic marker for response in patients with CRPC treated with enzalutamide, and we confirmed the prognostic value of miR-375. +other 32408351 hsa-mir-375 Prostatic Neoplasms, Castration-Resistant RESULTS: Levels of 2 miRNAs, miR-375 and miR-3687, and 1 lncRNA, N-acetylated alpha-linked acidic dipeptidase like 2 antisense RNA 2 (NAALADL2-AS2), were more than 2-fold higher in patients with mCRPC compared with healthy volunteers. CONCLUSIONS: We identified miR-3687 as a novel prognostic marker for response in patients with CRPC treated with enzalutamide, and we confirmed the prognostic value of miR-375. +genetics_overexpression_suppress 32407879 hsa-mir-1278 Nasopharyngeal Carcinoma Gain-of-function experiments showed that overexpression of miR-1278 dramatically sensitized NPC cells to DDP and reduced autophagy. +genetics_overexpression_promote 32407730 hsa-mir-132 Retinoblastoma Finally, we found that SMAD2 overexpression or miR +lncRNA target 32407174 hsa-mir-371a Colorectal Neoplasms In conclusion, NR2F1-AS1 regulates miR-371a-3p/TOB1 axis to suppress proliferation of CRC cells. +lncRNA target 32407172 hsa-mir-619 Stomach Neoplasms Conclusions: PVT1 silencing attenuated the DPP resistance in GC by downregulating TBL1XR1 via sponging miR +genetics_knock down_promote 32407168 hsa-mir-452 Prostatic Neoplasms 5p and its knockdown weakened the promotive effects of miR +lncRNA target 32407167 hsa-mir-432 Prostatic Neoplasms CircSMARCA5/miR-432/PDCD10 axis might be an underlying therapeutic target for PCa treatment. +genetics_overexpression_promote 32407143 hsa-mir-140 Pancreatic Carcinoma Further studies revealed that overexpression of CDK8 reversed the miR +genetics_knock down_promote 32406953 hsa-mir-95 Prostatic Neoplasms In vitro and in vivo loss-of-function assays suggested that miR-95 could function as a tumor promoter by directly binding to its downstream target gene, JunB, to promote PCa cell proliferation, invasion, and epithelial-mesenchymal transition. +lncRNA target 32406793 hsa-mir-146b Gallbladder Neoplasms 3p) were exclusively dysregulated in GBC patients with long-term and short-term survival, respectively. +lncRNA target 32406793 hsa-mir-660 Gallbladder Neoplasms 3p) were exclusively dysregulated in GBC patients with long-term and short-term survival, respectively. +lncRNA target 32406793 hsa-mir-142 Gallbladder Neoplasms 3p) were exclusively dysregulated in GBC patients with long-term and short-term survival, respectively. +lncRNA target 32406793 hsa-mir-338 Gallbladder Neoplasms 3p) were exclusively dysregulated in GBC patients with long-term and short-term survival, respectively. +transcription factor target 32406529 hsa-mir-22 Spinal Cord Ischemia 3p facilitated M2 polarization of macrophages and inhibited inflammation in tissues by inhibiting IRF5, thereby attenuating spinal cord I/R injury. +circulation_biomarker_diagnosis_down 32406504 hsa-mir-192 Non-alcoholic Fatty Liver Disease CONCLUSION: Collectively, all data indicated that serum expression of miR +circulation_biomarker_diagnosis_down 32406504 hsa-mir-192 Pancreatitis CONCLUSION: Collectively, all data indicated that serum expression of miR +genetics_overexpression_promote 32406388 hsa-mir-20a Colorectal Neoplasms RESULTS Our data revealed that miR-20a expression was elevated in the CRC cell lines, and cell migration, proliferation, and invasion abilities were promoted by the overexpression of miR-20a. +other 32406376 hsa-mir-182 Breast Neoplasms Also, the hsa-miR-182 and decorin pair performs different functions among the four subtypes of breast cancer. +lncRNA target 32406336 hsa-mir-195 Lung Neoplasms 5p may regulate lung cancer growth and metastasis through the regulation of Forkhead box k1, highlighting the potential application for the treatment of lung cancer in the future. +other 32406197 hsa-mir-20a Infertility, Male CONCLUSIONS: MiR-20a-5p could represent a novel non-invasive diagnostic biomarker of male infertility. +lncRNA target 32406007 hsa-mir-512 Myocardial Infarction AFAP1-AS1 promoted the progression of MI by targeting miR +genetics_overexpression_promote 32405762 hsa-mir-146a Olfaction Disorders The present results showed that OD in T2D rats is associated with IL-1beta mediated-inflammation and miR-146a overexpression, suggesting that high levels of IL-1beta could trigger miR-146a upregulation as a negative feedback of the inflammatory response in the OB of T2D rats. +genetics_overexpression_promote 32405762 hsa-mir-146a Inflammation The present results showed that OD in T2D rats is associated with IL-1beta mediated-inflammation and miR-146a overexpression, suggesting that high levels of IL-1beta could trigger miR-146a upregulation as a negative feedback of the inflammatory response in the OB of T2D rats. +genetics_overexpression_promote 32405762 hsa-mir-146a Diabetes Mellitus, Type 2 The present results showed that OD in T2D rats is associated with IL-1beta mediated-inflammation and miR-146a overexpression, suggesting that high levels of IL-1beta could trigger miR-146a upregulation as a negative feedback of the inflammatory response in the OB of T2D rats. +lncRNA target 32405371 hsa-mir-1 Breast Neoplasms Using different strategies, it was revealed that cellular levels of miR-31 and Breast cancer Metastasis Suppressor1 (BRMS1) protein, which are among the most significant modulators of metastasis, have a correlation with the cell's capability for invading and metastasizing; cells containing higher levels of miR-31 or BRMS1 were less metastatic. +other 32405351 hsa-mir-133 Heart Injuries RESULTS: Ovariectomy significantly (P-value<0.05) increased cholesterol, triglyceride, LDL, Bax, caspase-3, caspase-8 and decreased (P-value<0.05) HDL, miR-133, Bcl-2 in the cardiac tissue and a further reduction in the expression of miR-133, Bcl-2 and an enhancement in Bax, caspase-3 and caspase-8 in OVR.D rats was observed (P-value<0.01). +other 32405351 hsa-mir-133 Diabetes Mellitus RESULTS: Ovariectomy significantly (P-value<0.05) increased cholesterol, triglyceride, LDL, Bax, caspase-3, caspase-8 and decreased (P-value<0.05) HDL, miR-133, Bcl-2 in the cardiac tissue and a further reduction in the expression of miR-133, Bcl-2 and an enhancement in Bax, caspase-3 and caspase-8 in OVR.D rats was observed (P-value<0.01). +exosome 32404916 hsa-mir-21 Subarachnoid Hemorrhage In addition, using miRNA profiling and CSF sequencing data from the exRNA Atlas, we demonstrated that EV-derived miR-21 protected neurons from apoptosis and alleviated SAH-induced cognitive dysfunction. +exosome 32404916 hsa-mir-21 Brain Injuries In addition, using miRNA profiling and CSF sequencing data from the exRNA Atlas, we demonstrated that EV-derived miR-21 protected neurons from apoptosis and alleviated SAH-induced cognitive dysfunction. +genetics_overexpression_promote 32404854 hsa-mir-765 Carcinoma, Hepatocellular RESULTS: The authors found that the LHPP gene levels in HCC tissues were lower than that in adjacent normal tissues, whereas miR-765 was overexpressed in HCC tissue. Overexpression of miR-765 promoted the epithelial-mesenchymal transition and proliferation and inhibited apoptosis of HCC through directly downregulating LHPP expression. +circulation_biomarker_diagnosis_ns 32404537 hsa-mir-423 Coronary Artery Disease CONCLUSIONS: Circulating miR +other 32404313 hsa-mir-122 Chemical and Drug Induced Liver Injury One such method examines the release of the liver-specific microRNA (miRNA) miR-122 from the liver into the vasculature as a result of hepatocellular damage, which could be due to drug-induced acute liver injury. +lncRNA target 32404197 hsa-mir-532 Osteoporosis 5p might serve as a therapeutic target for osteoporosis. +genetics_knock down_promote 32404179 hsa-mir-607 Carcinoma, Hepatocellular CONCLUSION: The data of this study indicated that the decreased expression of miR-3607 in HCC predicts poor prognosis and the overexpression of miR-3607 in HCC cells can suppress the tumor progression by targeting TGFBR1. +lncRNA target 32404105 hsa-mir-421 Spinal Cord Injuries CONCLUSIONS: In conclusion, M2 BMDM-sEVs inhibited the mTOR autophagy pathway by transmitting miR3p, which reduced neuronal apoptosis and promoted functional recovery after SCI, suggesting that M2 BMDM-sEVs may be a potential therapy for SCI. +other 32403919 hsa-mir-205 Carcinoma, Non-Small-Cell Lung Here, we reported a Na(+)-specific DNAzyme-based DNAzyme motor differentiating cell subtypes of nonsmall cell lung cancer by simultaneously sensing intracellular miRNA-21 and miRNA-205. +other 32403384 hsa-mir-21 Breast Neoplasms The relative expression levels of miRNA-20a; -21; -125b; -126; -200b; -181a; -205; -221; -222; -451a; -99a; -145; -200a; -214; -30a; -191; and small nuclear RNAs U6, U54, and U58 were measured by RT-qPCR in four intratumor areas in each of 33 luminal BC specimens and in surrounding normal mammary gland tissues. +other 32403384 hsa-mir-125b Breast Neoplasms The relative expression levels of miRNA-20a; -21; -125b; -126; -200b; -181a; -205; -221; -222; -451a; -99a; -145; -200a; -214; -30a; -191; and small nuclear RNAs U6, U54, and U58 were measured by RT-qPCR in four intratumor areas in each of 33 luminal BC specimens and in surrounding normal mammary gland tissues. +other 32403384 hsa-mir-20a Breast Neoplasms The relative expression levels of miRNA-20a; -21; -125b; -126; -200b; -181a; -205; -221; -222; -451a; -99a; -145; -200a; -214; -30a; -191; and small nuclear RNAs U6, U54, and U58 were measured by RT-qPCR in four intratumor areas in each of 33 luminal BC specimens and in surrounding normal mammary gland tissues. +lncRNA target 32403047 hsa-mir-138 Carcinoma, Non-Small-Cell Lung In conclusion, dysregulation of LINC00665 plays a vital role in NSCLC progression, indicating that its downregulation may confer decreased cell proliferation and invasion via the miR +transcription factor target 32402942 hsa-mir-449a Laryngeal Neoplasms Ectopic miR-449a expression in the LCa cell line Hep-2 inhibited invasion and motility in vitro, slowed cell proliferation, and induced the downregulation of Notch1 and Notch2 as direct targets of miR-449a. +genetics_knock down_suppress 32402941 hsa-mir-7 Uterine Cervical Neoplasms Knockdown of Sp1 additively enhanced KLK10 expression in MTA2-knocked down cervical cancer cells, suggesting that the miR-7/Sp1 axis acts as an effector of MTA2 to impact KLK10 levels and mobility of cervical cancer cells. Taken together, our findings provide new insights into the physiological relationship between MTA2 and KLK10 via regulating the miR-7/Sp1 axis, and they provide a potential therapeutic target in cervical cancer. +other 32402537 hsa-mir-182 Uterine Cervical Neoplasms 5p/FBXW7 axis is critical for CC progression, which might offer new insights into effective therapy for CC. +lncRNA target 32402408 hsa-mir-21 Pulmonary Arterial Hypertension Importantly, our findings further elucidated therapeutic mechanism of osthole, a natural product, having a role of metabolic regulator to potentially treat PAH by targeting inhibition of Sphk1/S1P via microRNAPI3K/Akt/mTOR signal pathway. +genetics_overexpression_promote 32401923 hsa-mir-221 Dehydration 3p, and its overexpression could reverse the inhibition effects of miR +genetics_overexpression_promote 32401923 hsa-mir-221 Inflammation 3p, and its overexpression could reverse the inhibition effects of miR +other 32401588 hsa-mir-216a Osteochondritis Dissecans Furthermore, CHR exposure ameliorated the effects that OGD-evoked, and elevated the expression of miR-216a, as well as the expression of crucial factors participated in PI3 K/AKT and JAK2/STAT3 pathways. Conclusion CHR exposure relieved OGD-evoked PC12 cell damage by elevating miR-216a expression and thereby activating of PI3 K/AKT and JAK2/STAT3 pathways. +lncRNA target 32401536 hsa-mir-137 Ovarian Neoplasms In summary, our study clarified the role of SCAMP1/miR-137/CXCL12 axis in OC, and this finding may provide a potential therapeutic target of OC. +transcription factor target 32401366 hsa-mir-216a Uterine Cervical Neoplasms Taken together, these data demonstrate that miR-216a-3p acts as a potential tumor-suppressive miRNA in cervical cancer, which exerts its function through inhibition of YAP signaling via targeting ACTL6A. +other 32401176 hsa-mir-155 Tuberculosis We found a significant upregulation of miR-21, miR-29a, miR-31, miR-155, and downregulation of miR-146a in children with active-TB compared to HC. The ROC analysis indicated that miRNAs miR-31, miR-155 and miR-146a could be effective diagnostic biomarkers for the detection of active-TB in children. +other 32401176 hsa-mir-1 Tuberculosis We found a significant upregulation of miR-21, miR-29a, miR-31, miR-155, and downregulation of miR-146a in children with active-TB compared to HC. The ROC analysis indicated that miRNAs miR-31, miR-155 and miR-146a could be effective diagnostic biomarkers for the detection of active-TB in children. +other 32401176 hsa-mir-146a Tuberculosis We found a significant upregulation of miR-21, miR-29a, miR-31, miR-155, and downregulation of miR-146a in children with active-TB compared to HC. The ROC analysis indicated that miRNAs miR-31, miR-155 and miR-146a could be effective diagnostic biomarkers for the detection of active-TB in children. +other 32401141 hsa-mir-34 Developmental Disabilities Ablation of miR-34 by transgenic CRISPR/Cas9 technology resulted in a severe developmental delay during the larval stage. +genetics_overexpression_suppress 32401035 hsa-mir-21 Esophageal Squamous Cell Carcinoma Overexpression of LINC-PINT could inhibit the expression of miRNA-21 in human ESCC cells, whereas LINC-PINT expression was not altered by miR-21 overexpression. +exosome 32400849 hsa-mir-146a Osteoporosis Hence, our findings suggested that Rtn4-Exos attenuated TNF-alpha-induced cytotoxicity and apoptosis in murine MC3T3-E1 cells by sponging miR-146a, suggesting that Rtn4-Exos may serve as novel candidates for treating osteoporosis. +other 32400219 hsa-mir-124 Hypoxia-Ischemia, Brain Thus, nasal delivery of RVG29-PEG-PLGA/miRNA-124 could be a new method for treating neurodegenerative diseases. +other 32400192 hsa-mir-155 Diabetic Neuropathies Conclusion: miR-128a, miR-155 and miR-499a might be involved in diabetic neuropathies development. +other 32400192 hsa-mir-128a Diabetic Neuropathies Conclusion: miR-128a, miR-155 and miR-499a might be involved in diabetic neuropathies development. +other 32400192 hsa-mir-499a Diabetic Neuropathies Conclusion: miR-128a, miR-155 and miR-499a might be involved in diabetic neuropathies development. +circulation_biomarker_diagnosis_up 32400052 hsa-let-7a Heart Failure 5p were significantly higher, and let-7a-5p was significantly lower in HF patients compared with healthy controls, whereas no such difference was observed for those markers in the serum samples among the groups. +transcription factor target 32399769 hsa-mir-497 Polycystic Ovary Syndrome miR5p may be a novel target for PCO therapy. +other 32399402 hsa-mir-494 Retinoblastoma "Two pathways including ""cell cycle"" and ""pathway in cancer"" in CTD and enrichment analysis were identified and seven miRNAs (including hsa-miR-373, hsa-miR-34a, hsa-miR-129, hsa-miR-494, hsa-miR-503, hsa-let-7 and hsa-miR-518c) were associated with RB." +other 32399402 hsa-mir-518c Retinoblastoma "Two pathways including ""cell cycle"" and ""pathway in cancer"" in CTD and enrichment analysis were identified and seven miRNAs (including hsa-miR-373, hsa-miR-34a, hsa-miR-129, hsa-miR-494, hsa-miR-503, hsa-let-7 and hsa-miR-518c) were associated with RB." +other 32399402 hsa-mir-34a Retinoblastoma "Two pathways including ""cell cycle"" and ""pathway in cancer"" in CTD and enrichment analysis were identified and seven miRNAs (including hsa-miR-373, hsa-miR-34a, hsa-miR-129, hsa-miR-494, hsa-miR-503, hsa-let-7 and hsa-miR-518c) were associated with RB." +other 32399402 hsa-mir-129 Retinoblastoma "Two pathways including ""cell cycle"" and ""pathway in cancer"" in CTD and enrichment analysis were identified and seven miRNAs (including hsa-miR-373, hsa-miR-34a, hsa-miR-129, hsa-miR-494, hsa-miR-503, hsa-let-7 and hsa-miR-518c) were associated with RB." +other 32399402 hsa-mir-373 Retinoblastoma "Two pathways including ""cell cycle"" and ""pathway in cancer"" in CTD and enrichment analysis were identified and seven miRNAs (including hsa-miR-373, hsa-miR-34a, hsa-miR-129, hsa-miR-494, hsa-miR-503, hsa-let-7 and hsa-miR-518c) were associated with RB." +other 32399402 hsa-let-7 Retinoblastoma "Two pathways including ""cell cycle"" and ""pathway in cancer"" in CTD and enrichment analysis were identified and seven miRNAs (including hsa-miR-373, hsa-miR-34a, hsa-miR-129, hsa-miR-494, hsa-miR-503, hsa-let-7 and hsa-miR-518c) were associated with RB." +other 32399402 hsa-mir-503 Retinoblastoma "Two pathways including ""cell cycle"" and ""pathway in cancer"" in CTD and enrichment analysis were identified and seven miRNAs (including hsa-miR-373, hsa-miR-34a, hsa-miR-129, hsa-miR-494, hsa-miR-503, hsa-let-7 and hsa-miR-518c) were associated with RB." +circulation_biomarker_diagnosis_up 32399091 hsa-mir-1291 Pemphigoid, Bullous miR-1291 may function as an important new serum biomarker for BP. +genetics_knock down_promote 32398968 hsa-mir-15b Uterine Cervical Neoplasms Gain- or loss-of-function experiments revealed the biological effects of FENDRR and miR-15a/b-5p on CC cell functions. CONCLUSION: FENDRR inhibits CC progression through upregulating TUBA1A in a miR-15a/b-5p-dependent manner. +genetics_knock down_promote 32398968 hsa-mir-15a Uterine Cervical Neoplasms Gain- or loss-of-function experiments revealed the biological effects of FENDRR and miR-15a/b-5p on CC cell functions. CONCLUSION: FENDRR inhibits CC progression through upregulating TUBA1A in a miR-15a/b-5p-dependent manner. +target gene 32398967 hsa-mir-147 Urinary Bladder Neoplasms Hsa_circ_0068307 mediates bladder cancer stem cell-like properties via miR-147/c-Myc axis regulation. +exosome 32398867 hsa-mir-9 Breast Neoplasms Furthermore, miR-9 and miR-181a promoted 4T1 tumor growth and immune escape via enhancing eMDSCs infiltration in situ. In summary, our findings indicated that tumor exosome-derived miR-9 and miR-181a activated the JAK/STAT signaling pathway via targeting SOCS3 and PIAS3, respectively, and thus promoted the expansion of eMDSCs which might provide potential therapeutic target for IL-6(high) breast cancer treatment. +exosome 32398867 hsa-mir-181a Breast Neoplasms Furthermore, miR-9 and miR-181a promoted 4T1 tumor growth and immune escape via enhancing eMDSCs infiltration in situ. In summary, our findings indicated that tumor exosome-derived miR-9 and miR-181a activated the JAK/STAT signaling pathway via targeting SOCS3 and PIAS3, respectively, and thus promoted the expansion of eMDSCs which might provide potential therapeutic target for IL-6(high) breast cancer treatment. +genetics_overexpression_promote 32398664 hsa-mir-15b Carcinoma, Hepatocellular Rescue experiments testified that GLI2 overexpression could recover circZNF609 depletion-mediated function on HCC development while miR-15a-5p/15b-5p inhibition could partially rescue circZNF609 silencing-mediated effect on HCC progression. Briefly, circZNF609 enhances HCC cell proliferation, metastasis, and stemness by activating the Hedgehog pathway through the regulation of miR-15a-5p/15b-5p and GLI2 expressions. +genetics_overexpression_promote 32398664 hsa-mir-15a Carcinoma, Hepatocellular Rescue experiments testified that GLI2 overexpression could recover circZNF609 depletion-mediated function on HCC development while miR-15a-5p/15b-5p inhibition could partially rescue circZNF609 silencing-mediated effect on HCC progression. Briefly, circZNF609 enhances HCC cell proliferation, metastasis, and stemness by activating the Hedgehog pathway through the regulation of miR-15a-5p/15b-5p and GLI2 expressions. +lncRNA target 32398474 hsa-mir-375 Myocardial Infarction In addition, we elaborated that LNC_000898 exerts its inhibitory effect on apoptosis after MI through the miR-375/PDK1 axis. These data not only demonstrate that LNC_000898 could protect the heart against MI injury by regulating miR-375/PDK1 but also provide a new understanding to better protection of MI injury through the LNC_000898/miR-375/PDK1 axis. +lncRNA target 32398261 hsa-mir-200b Thyroid Carcinoma, Anaplastic This increased expression was due at least in part to reduced levels of microRNA-200b-3p (miR-200b-3p), which represses ASH1L expression, in ATC. These results indicate that ASH1L contributes to the aggressiveness of ATC and suggest that ASH1L, along with its upstream regulator miR-200b-3p and its downstream mediator CCAT1, represents a potential therapeutic target in ATC. +lncRNA target 32397872 hsa-mir-342 Nasopharyngeal Carcinoma In conclusion, LINC00346 regulates the cisplatin resistance of NPC cells by inhibiting miR5p, which could provide a potential target for chemotherapy resistance. +other 32397799 hsa-mir-9 Carcinoma, Hepatocellular 5p to upregulate CNNM1 in promoting HCC progression. +lncRNA target 32397798 hsa-mir-619 gastric adenocarcinoma 5p controls STAD carcinogenesis and progression through modulating TBC1D10B expression, which may provide a novel insight for researching the STAD-related molecular mechanism. +lncRNA target 32397779 hsa-mir-129 Bronchopulmonary Dysplasia CONCLUSION: MALAT1 reduced the expression of miR5p, promoting the viability of cells and blocking the development of bronchopulmonary dysplasia. +other 32397522 hsa-mir-143 Coronary Artery Disease 3p. +other 32397522 hsa-mir-16 Coronary Artery Disease 3p. +lncRNA target 32397324 hsa-mir-144 Cardiomegaly Inhibition of miR-144 expression in primary myocardial cells caused up-regulation of cardiac hypertrophy markers atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). Long non-coding RNA myocardial infarction associated transcript (LncMIAT) is closely related to heart disease, and here, we were the first to discover that LncMIAT may act as an miR-144 sponge in isoproterenol-induced cardiac hypertrophy. +transcription factor target 32397166 hsa-mir-21 Diabetes Mellitus Dysregulation of miR-21 may explain the abnormal inflammation and persistent M1 macrophage polarization seen in diabetic wounds. +genetics_overexpression_promote 32396871 hsa-mir-23b Carcinoma, Non-Small-Cell Lung Rescue experiments confirmed that KTN1-AS1 overexpression could increase the colony formation and migration ability suppressed by miR-23b upregulation in NSCLC cells. +other 32396572 hsa-mir-183 Breast Neoplasms The goal of this study was to investigate the role of miR-96 and miR-183 in EMT in breast cancer. Both miR-96 and miR-183 were found to be downregulated in post-EMT breast cancer cells. +other 32396572 hsa-mir-96 Breast Neoplasms The goal of this study was to investigate the role of miR-96 and miR-183 in EMT in breast cancer. Both miR-96 and miR-183 were found to be downregulated in post-EMT breast cancer cells. +other 32396270 hsa-mir-1 psoriasis 1 Our results showed that coculture of NHEK with psoriatic DMSC induced 32 differentially expressed miRNA, in which expression levels of miR-1 increased approximately 16-fold over control DMSC-treated NHEK (P < 0.05). +genetics_overexpression_promote 32396269 hsa-mir-210 Lung Neoplasms 3p may bind to fibroblast growth factor receptor-like 1 (FGFRL1); silencing FGFRL1 enhanced the metastatic ability of lung cancer cells, whereas overexpressing FGFRL1 suppressed metastasis. +epigenetics 32395888 hsa-mir-214 Carcinoma, Renal Cell In conclusion, these results suggest that abnormal miR-214 methylation negatively regulates LIVIN, which may promote RCC cells growth and reduced the sensitivity of RCC cells to chemotherapeutic drugs. +other 32395887 hsa-mir-133a Hypertension, Pulmonary We hypothesized that heart-relevant microRNAs, that is myomiRs (miR-1, miR-133a, miR-208, miR-499) and miR-214, can have a role in the right ventricle in the development of PAH. +other 32395887 hsa-mir-214 Hypertension, Pulmonary We hypothesized that heart-relevant microRNAs, that is myomiRs (miR-1, miR-133a, miR-208, miR-499) and miR-214, can have a role in the right ventricle in the development of PAH. +other 32395887 hsa-mir-499 Hypertension, Pulmonary We hypothesized that heart-relevant microRNAs, that is myomiRs (miR-1, miR-133a, miR-208, miR-499) and miR-214, can have a role in the right ventricle in the development of PAH. +other 32395887 hsa-mir-208 Hypertension, Pulmonary We hypothesized that heart-relevant microRNAs, that is myomiRs (miR-1, miR-133a, miR-208, miR-499) and miR-214, can have a role in the right ventricle in the development of PAH. +other 32395887 hsa-mir-208a Hypertension, Pulmonary We hypothesized that heart-relevant microRNAs, that is myomiRs (miR-1, miR-133a, miR-208, miR-499) and miR-214, can have a role in the right ventricle in the development of PAH. +other 32395887 hsa-mir-1 Hypertension, Pulmonary We hypothesized that heart-relevant microRNAs, that is myomiRs (miR-1, miR-133a, miR-208, miR-499) and miR-214, can have a role in the right ventricle in the development of PAH. +other 32395770 hsa-mir-122 Osteoarthritis CONCLUSION: The miR-122/SIRT1 axis can regulate the degradation of ECM in OA, thus providing new insights into the treatment of OA. +lncRNA target 32395744 hsa-mir-106b Dehydration In brief, matrine modulated H2O2-induced myocardial oxidative stress repair through HOTAIR/miR-106b-5p axis via AKT and STAT3 signaling pathway. +other 32395528 hsa-mir-105 Stomach Neoplasms CONCLUSIONS: MiR-30a-3p and miR5p are potential biomarkers for the MSI-H gastric adenocarcinoma, possibly by altering expression of DNA damage-repair genes. +lncRNA target 32395477 hsa-mir-18a Pancreatic Carcinoma MicroRNA-18a may be a novel target in the treatment of pancreatic cancer in future. +lncRNA target 32395334 hsa-mir-101 Lupus Erythematosus, Systemic RESULTS: Because glycolysis is increased in SLE CD4(+) T cells and glycolysis regulates miR-26a and miR-101, which target EZH2, we examined the effect of inhibiting glycolysis on EZH2 expression. Indeed, inhibiting mTORC1 increased miR-26a and miR-101 and suppressed EZH2 expression in SLE CD4(+) T cells. +lncRNA target 32395334 hsa-mir-26a Lupus Erythematosus, Systemic RESULTS: Because glycolysis is increased in SLE CD4(+) T cells and glycolysis regulates miR-26a and miR-101, which target EZH2, we examined the effect of inhibiting glycolysis on EZH2 expression. Indeed, inhibiting mTORC1 increased miR-26a and miR-101 and suppressed EZH2 expression in SLE CD4(+) T cells. +genetics_overexpression_promote 32395291 hsa-mir-107 Carcinoma, Non-Small-Cell Lung Overexpression of miR-107 inhibited malignant biological behavior of NSCLC cell lines, and suppressed tumor growth in vivo. +other 32394971 hsa-mir-22 Spinal Cord Ischemia As such, miR3p may play sustained regulatory roles in spinal cord ischemia-reperfusion injury. +circulation_biomarker_diagnosis_ns 32394711 hsa-mir-486 Lung Neoplasms 5p in lung cancer cells at various stages, and even discriminate the expressions of serum circulating miR +circulation_biomarker_diagnosis_ns 32394711 hsa-mir-486 Carcinoma, Non-Small-Cell Lung 5p in lung cancer cells at various stages, and even discriminate the expressions of serum circulating miR +other 32394377 hsa-mir-21 Papilloma, Choroid Plexus We found that the cancer cell lines HT-29, CACO-2, and HeLa cells express miR-21 when measured by ISH, and used those cell lines to obtain PECCs. +other 32394377 hsa-mir-21 Colonic Neoplasms Image analysis of the miR-21 ISH signal has shown that increased expression estimate is associated with poor prognosis in colon cancer. +transcription factor target 32394334 hsa-mir-21 Triple Negative Breast Neoplasms Compared with DTX or anti-miR-21 formulations used alone, the co-delivery of the two drugs with the combo chitosome obtained improved chemosensitivity of TNBC cells to DTX treatment through their synergistic mechanisms. +other 32394009 hsa-mir-335 Aortic Aneurysm, Abdominal 5p with good reproducibility for determination of the severity of AAA. +genetics_knock down_promote 32393810 hsa-mir-6086 Ovarian Neoplasms In addition, miR-6086, siOC2 and siEGFL6 could negatively regulate the tumor growth and angiogenesis of ovarian cancer (Skov3) in the animal studies, with the inhibition rates of 77.07%, 69.89%, and 73.62%, respectively (**p < 0.01). +other 32393764 hsa-mir-1299 Carcinoma, Hepatocellular Moreover, circMAST1 elicits HCC progression by sponging miRNA-1299 and stabilizing CTNND1. +other 32393661 hsa-mir-137 Pancreatic Carcinoma Of the disease-associated fibroblasts examined, PDAC- and CP-derived fibroblasts shared greatest similarity, yet PDAC-associated fibroblasts expressed higher levels of tenascin C (TNC), a finding attributable to miR-137, a novel regulator of TNC. +other 32393661 hsa-mir-137 isolated cleft palate Of the disease-associated fibroblasts examined, PDAC- and CP-derived fibroblasts shared greatest similarity, yet PDAC-associated fibroblasts expressed higher levels of tenascin C (TNC), a finding attributable to miR-137, a novel regulator of TNC. +transcription factor target 32393392 hsa-mir-486 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: Based on these results, we demonstrated a new post-transcriptional mechanism of EVI5 regulation via miR +lncRNA target 32392329 hsa-mir-146a Nerve Degeneration Here, we report the role of activated nuclear factor kappa beta (NF-kbeta) in miR-146a-mediated downregulation of Parkin protein, which inhibits clearance of damaged mitochondria and induces neurodegeneration. +other 32392228 hsa-mir-208a Atrial Fibrillation Of particular note, AF-associated miR-130b-3p, miR5p and miR-208a-3p were differentially expressed in our AF tissue samples. +other 32392228 hsa-mir-338 Atrial Fibrillation Of particular note, AF-associated miR-130b-3p, miR5p and miR-208a-3p were differentially expressed in our AF tissue samples. +other 32392228 hsa-mir-130b Atrial Fibrillation Of particular note, AF-associated miR-130b-3p, miR5p and miR-208a-3p were differentially expressed in our AF tissue samples. +other 32392158 hsa-mir-101 Alzheimer Disease Sensitive and selective detection of multiple Alzheimer's biomarkers including Tau, ApoE4, Amyloid-beta and miRNA-101 on such mini-pillar-based biosensor is also achieved. +circulation_biomarker_diagnosis_up 32392088 hsa-mir-30 Cardiotoxicity Bioinformatic analysis, luciferase reporter assays, and quantitative polymerase chain reaction showed that SIRT6 (sirtuin 6), BIRC5 (baculoviral IAP repeat containing 5, Survivin), and ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca(2+) transporting 2, SERCA2a [SR Ca(2+)-ATPase 2]) were direct targets of miR +genetics_overexpression_promote 32391804 hsa-mir-34 Stomach Neoplasms overexpressing GCFs led to the suppression of cancer progression. +lncRNA target 32391718 hsa-mir-492 Breast Neoplasms Materials and Methods: The expressions of circ_0000526, miR-492, and suppressor of cytokine signaling 2 (SOCS2) in breast cancer samples were measured using quantitative real-time polymerase chain reaction. Conclusions: Circ_0000526 served as a tumor suppressor, which could function as the sponge of miR-492, an oncogenic microRNA, in breast cancer, and enhance the expression of tumor suppressor SOCS2 indirectly. +lncRNA target 32391716 hsa-mir-514a Carcinoma, Hepatocellular Conclusions: All in all, TRIM52-AS1 sponged miR-514a-5p to facilitate HCC progression through increasing MRPS18A expression. +lncRNA target 32391614 hsa-mir-143 Diabetic Nephropathies CONCLUSIONS: Our studies demonstrated that the protective effect of MET on DN was attributed to the inhibition of proliferation, inflammation and ECM accumulation in mesangial cells via H19/miR +other 32391602 hsa-mir-200c Lung Neoplasms Preclinical experiments with osimertinib-resistant lung cancer cells showed that EMT was associated with decreased microRNA-200c and increased ZEB1 expression. +circulation_biomarker_diagnosis_up 32391592 hsa-mir-127 Ovarian Insufficiency, Premature 5p was also detected in plasma of bPOI individuals, suggesting that miR +lncRNA target 32391554 hsa-mir-138 Colorectal Neoplasms TUG1 could promote the development of CRC via the miR +genetics_GWAS 32391354 hsa-mir-409 Carcinoma, Non-Small-Cell Lung 3p/SOD1/SETDB1 epigenetic regulatory feedforward loop may provide new insights into further understanding of NSCLC tumorigenesis and progression. +genetics_overexpression_promote 32391253 hsa-mir-22 Osteosarcoma When overexpressed, miR-22 suppressed Twist1 translation and thereby attenuated the EMT in OS cells. +transcription factor target 32391100 hsa-mir-758 Colorectal Neoplasms In addition, it was confirmed that miR-758 directly targets PAX6 and inhibits CRC progression through targeting PAX6. +lncRNA target 32391042 hsa-mir-100 Pulmonary Arterial Hypertension CONCLUSION: LDHA, PFKP, VEGFA, and lncRNA miR-100HG and TSPEAR-AS2 probably played crucial roles in the pathogenesis of CoCl(2) hypoxia-induced-HAP, which might serve as promising therapeutic targets for PAH. +circulation_biomarker_diagnosis_ns 32390950 hsa-mir-15a Diabetes Mellitus, Type 2 The assessment of plasma microRNA-15a may help refining risk assessment and secondary prevention in patients with preclinical T2DM. +circulation_biomarker_diagnosis_ns 32390950 hsa-mir-15a Retinal Diseases The assessment of plasma microRNA-15a may help refining risk assessment and secondary prevention in patients with preclinical T2DM. +other 32390766 hsa-mir-24-1 Breast Neoplasms LncRNA IGBP1-AS1/miR1/ZIC3 axis as a loop can regulate the proliferation and invasion of BC cells. +lncRNA target 32390763 hsa-mir-133b Squamous Cell Carcinoma of Head and Neck CONCLUSION: Downregulation of TUG1 impeded cisplatin resistance in TSCC-resistant cells by mediating miR-133b and CXCR4, indicating TUG1 as a promising target for TSCC chemotherapy. +lncRNA target 32390762 hsa-mir-519a Osteosarcoma Rescue assays verified the oncogenic effect of LINC01419/miR-519a-3p/PDRG1 axis on OS development. CONCLUSION: LINC01419 mediates malignant phenotypes in OS by targeting miR-519a-3p/PDRG1 axis. +other 32390604 hsa-mir-483 Hepatoblastoma CONCLUSIONS: The expansion of the four-miR signature by miR-483 serves as a useful biomarker to predict outcome of HB patients. +genetics_overexpression_promote 32390603 hsa-mir-892a Stomach Neoplasms Overexpression of miR-892a promoted cell proliferation, migration, and invasion of gastric cancer cells. +lncRNA target 32390598 hsa-mir-4458 Osteosarcoma CONCLUSIONS: This research for the first time documented that circ_0000337 promoted OS progression via sponging miR-4458 and thus elevating BACH1 expression, offering rational therapeutic target for OS. +transcription factor target 32390525 hsa-mir-21 Myocardial Infarction We sought to determine whether H(2)S attenuates ischemic heart failure with reduced ejection fraction (HFrEF) and interrogate the role of cofilin-2, a target of miR-21, in this protective process. +transcription factor target 32390525 hsa-mir-21 Myocardial Infarction, Acute We sought to determine whether H(2)S attenuates ischemic heart failure with reduced ejection fraction (HFrEF) and interrogate the role of cofilin-2, a target of miR-21, in this protective process. +circulation_biomarker_diagnosis_up 32390388 hsa-mir-513a Diabetes Mellitus, Type 2 CONCLUSIONS: Decreased plasma miR-513a-5p level may act as a potential biomarker for diagnosis of NAFLD in T2DM patients. +circulation_biomarker_diagnosis_up 32390388 hsa-mir-513a Non-alcoholic Fatty Liver Disease CONCLUSIONS: Decreased plasma miR-513a-5p level may act as a potential biomarker for diagnosis of NAFLD in T2DM patients. +genetics_overexpression_suppress 32390360 hsa-mir-22 Uterine Cervical Neoplasms CONCLUSION: miR-22 in cervical cancer is downregulated, resulting in NUP210 overexpression and inhibition of Fas-induced cell apoptosis. +genetics_knock down_promote 32390359 hsa-mir-342 Osteosarcoma CONCLUSION: LINC00313 is upregulated in OS, and LINC00313 knockdown plays a vital anti-tumor role in OS cell progression through a miR +other 32390141 hsa-mir-186 Ovarian Neoplasms Mechanism research exhibited the regulation role of TUG1 in ovarian cancer cells was miR5p/ZEB1 axis depended. +other 32389806 hsa-mir-9 Osteoporosis In osteoporotic patients with hBMSCs, the expression of miR5p was upregulated and the expression of XIST was downregulated. +genetics_GWAS 32389629 hsa-mir-146a Cardiomyopathy, Hypertrophic METHODS: In this study, 140 HCM patients and 112 control individuals were genotyped for the rs2910164 single nucleotide polymorphism (SNP) in the MIR146A gene; using this data, the correlation between different genotypes and clinical features of the disease were determined. +other 32389118 hsa-mir-520 Vessel Restenosis COX and PTGDS Gene Expression Levels in PGD2 Synthesis Pathway are Correlated with miR-520 in Patients with Vessel Restenosis. +circulation_biomarker_diagnosis_ns 32389118 hsa-mir-520a Vessel Restenosis In this study, we investigated the COX-1, COX-2, PTGDS and miRNA-520a-5p expression levels and the serum 15-Deoxy-12,14-PGJ2 metabolite values in patients with the stenosed and re-stenosed vessels. +circulation_biomarker_diagnosis_ns 32388809 hsa-mir-142 Adenocarcinoma of Lung Seven serum miRNAs (miR +circulation_biomarker_diagnosis_ns 32388809 hsa-mir-223 Adenocarcinoma of Lung Seven serum miRNAs (miR +other 32388809 hsa-mir-146a Adenocarcinoma of Lung 3p (AUC = 0.828) and miR-146a-5p (AUC = 0.745) being more prominent. +circulation_biomarker_diagnosis_ns 32388809 hsa-mir-409 Adenocarcinoma of Lung Seven serum miRNAs (miR +genetics_overexpression_promote 32388751 hsa-mir-130a Osteoarthritis Key Points * CTBP1-AS2 is overexpressed in OA and may downregulate miR-130a through methylation to suppress the proliferation of chondrocytes. +other 32388720 hsa-mir-205 Nevi and Melanomas In situ hybridisation confirmed the expression of miRNA 21 and 211 in melanocytes, while demonstrating expression of miRNA 205 only in keratinocytes, thus calling into question its value as a biomarker of melanocytic lesions. +other 32388720 hsa-mir-21 Nevi and Melanomas In conclusion, we have validated some miRNAs, including miRNA 21 and 211, as potential diagnostic biomarkers of benign, dysplastic, and malignant melanocytic lesions. +other 32388607 hsa-mir-138 Multiple Myeloma We demonstrate here for the first time that the novel Twist1/hsa-miR138-5p/caspase-3 pathway contributes significantly to the proliferation and survival of human MM cells. +lncRNA target 32387587 hsa-mir-1 Osteochondritis Dissecans 3p could enhance OD of MC3T3-E1 cells through interacting with HIF1AN, which might be employed as therapeutic applications for bone formation and regeneration. +genetics_GWAS 32387379 hsa-mir-200a Conjunctival Diseases In conclusion, our results indicate that DNA demethylation of promoters of miR-200 loci is critically important for stopping and reverting the EMT in human conjunctival epithelial cells, suggesting the potential for the development of novel epigenetic-based therapeutic strategies for treating conjunctival conditions associated with EMT. +genetics_knock down_promote 32387370 hsa-mir-712 Endometrial Hyperplasia Loss- and gain-of-function experiments revealed that transfection of miR +transcription factor target 32387370 hsa-mir-712 Vascular Diseases Targeting miR5p may be a novel therapeutic strategy to prevent proliferative vascular diseases. +transcription factor target 32387352 hsa-mir-1290 Glioblastoma Moreover, hsa-miR-1290 may be employed as a therapeutic target for clinical therapy of glioblastoma. +genetics_overexpression_promote 32386516 hsa-mir-6792 Stomach Neoplasms Functionally, overexpression of circCCDC9 significantly inhibited the proliferation, migration and invasion of GC cell lines in vitro and tumor growth and metastasis in vivo, whereas miR +other 32386483 hsa-mir-577 Carcinoma, Non-Small-Cell Lung DSCAM-AS1 and HMGB1 were upregulated, while miR-577 was downregulated in NSCLC tissues and cells. +lncRNA target 32386479 hsa-mir-15a Breast Neoplasms The rescue experiments revealed that miR-15a-5p inhibitor restored SNHG12 silencing induced inhibition on BC cell proliferation, migration, invasion, and promotion of apoptosis. +transcription factor target 32386397 hsa-mir-29b Chorioamnionitis IMPACT: Decreases in miR-29b are associated with intrauterine inflammation. MiR-29b may be an additional biomarker for neonatal outcomes and a potential therapeutic target for intrauterine inflammation. +transcription factor target 32386397 hsa-mir-29 Chorioamnionitis IMPACT: Decreases in miR-29b are associated with intrauterine inflammation. MiR-29b may be an additional biomarker for neonatal outcomes and a potential therapeutic target for intrauterine inflammation. +other 32386291 hsa-mir-16 Hip Fractures LASSO regression identified a biomarker subset that accounted for 27% of the total variance in the ERD and included a metabolic factor (aspartate/asparagine, C22, C5:1, lactate, glutamate/mine), TNFR-I, miR-376a-3p, and miR5p. +lncRNA target 32386284 hsa-mir-182 Carcinoma, Non-Small-Cell Lung 5p to suppress the invasion and migration of NSCLC cells via upregulating NME2 expression. +genetics_overexpression_promote 32386256 hsa-mir-874 Osteosarcoma CONCLUSIONS: In conclusion, overexpression of miR +lncRNA target 32386020 hsa-mir-92a Pancreatic Carcinoma OBJECTIVES: To explore the effect of miR-92a-3p on the proliferation and metastasis of pancreatic cancer cells via targeting phosphatase and tension homolog deleted on chromosome ten (PTEN). +other 32385800 hsa-mir-421 Reperfusion Injury, Cerebral Ischemia Our study is designed to examine the role of miR-421 antagomir in cerebral ischemia/reperfusion injuries, as well as its underlying mechanisms. MiR-421 might provide a new therapeutic direction for ischemia/reperfusion injuries. +genetics_overexpression_promote 32385717 hsa-mir-126 Uterine Cervical Neoplasms A series of mimics, inhibitors, overexpressing plasmids or siRNAs were introduced into CC cells to alter the circ9119, miR-126, and MDM4 expressions. +lncRNA target 32385217 hsa-mir-140 Ovarian Neoplasms 3p suppressed NK cytotoxicity to OC cells via mediating MAPK1, indicating a new avenue of ameliorating NK cells function for OC treatment. +genetics_overexpression_promote 32384924 hsa-mir-15a Epilepsy, Temporal Lobe CONCLUSIONS: MiR-15a-5p is downregulated in children with TLE, and overexpression of miR-15a-5p promoted the viability and inhibited the apoptosis of hippocampal neuron. +exosome 32384281 hsa-mir-92a Myocardial Infarction LncRNA-MALAT1/miR-92a-3p/ATG4a partially mediates the cardioprotective roles of exosome(Hypoxia) in Dox-induced cardiac damage. +circulation_biomarker_diagnosis_ns 32384264 hsa-mir-26a Brain Neoplasms RESULTS: miR-26a-5p correlated strongly in JPA patients within both the serum and tumor tissue samples (R2 = 0.951, p = 0.046), and serum levels were highly predictive of JPA (area under the curve = 0.751, p = 0.027). +other 32383554 hsa-mir-410 Stomach Neoplasms 3p were down-regulated in gastric cancer tissue samples, while they were significantly up-regulated in gastric cancer cell culture medium compared with cancer cells. +other 32383554 hsa-mir-379 Stomach Neoplasms 3p were down-regulated in gastric cancer tissue samples, while they were significantly up-regulated in gastric cancer cell culture medium compared with cancer cells. +circRNA target 32383354 hsa-mir-20b Sepsis Down-regulation of circDMNT3B was conducive to the dysfunction of intestinal mucosal permeability via sponging miR-20b-5p in sepsis rats, which may provide the novel strategy for sepsis treatment in the future. +circRNA target 32383354 hsa-mir-20b Intestinal Diseases Down-regulation of circDMNT3B was conducive to the dysfunction of intestinal mucosal permeability via sponging miR-20b-5p in sepsis rats, which may provide the novel strategy for sepsis treatment in the future. +lncRNA target 32383156 hsa-mir-29a Aortic Aneurysm, Abdominal Further, when the expression of miRNA-29a-3p was downregulated, it reduced the cell viability of AAA cells. +therapeutic target 32382656 hsa-mir-124 Colorectal Neoplasms miR-124 Intensified Oxaliplatin-Based Chemotherapy by Targeting CAPN2 in Colorectal Cancer. +other 32382575 hsa-mir-22 Metabolic Diseases 3p in PBMCs may be important biomarkers of stress reaction and may play a role in vulnerability to MetS. +other 32382575 hsa-mir-18a Metabolic Diseases 3p in PBMCs may be important biomarkers of stress reaction and may play a role in vulnerability to MetS. +circulation_biomarker_diagnosis_ns 32382558 hsa-mir-375 Hepatitis B CONCLUSIONS: Serum miR-375 levels are closely related to disease progression from HBV-related hepatitis or cirrhosis to HCC. +circulation_biomarker_diagnosis_ns 32382558 hsa-mir-375 Carcinoma, Hepatocellular CONCLUSIONS: Serum miR-375 levels are closely related to disease progression from HBV-related hepatitis or cirrhosis to HCC. +circulation_biomarker_diagnosis_up 32382553 hsa-mir-181b Lupus Erythematosus, Systemic miR-181b expression levels in plasma of SLE patients and controls were analyzed using quantitative PCR. +lncRNA target 32382354 hsa-mir-18a Mesothelioma In a chemosensitivity assay, transfection of the miR-18a inhibitor significantly increased the sensitivity of mesothelioma cells to cisplatin but not to pemetrexed. +epigenetics 32382328 hsa-mir-378a Colorectal Neoplasms The mechanisms of LBX2 upregulation in CRC are possibly associated with LBX2 DNA hypomethylation and miR-378a-3p downregulation. +genetics_overexpression_promote 32382323 hsa-mir-663b Colorectal Neoplasms Therefore, overexpression of miR-663b was able to promote CRC cell proliferation, migration and invasion by regulating the Wnt/beta-catenin pathway through targeting APC2, suggesting that miR-663b may be a useful target for the diagnosis and treatment of CRC. +genetics_overexpression_promote 32382323 hsa-mir-663b Adenomatous Polyposis Coli Therefore, overexpression of miR-663b was able to promote CRC cell proliferation, migration and invasion by regulating the Wnt/beta-catenin pathway through targeting APC2, suggesting that miR-663b may be a useful target for the diagnosis and treatment of CRC. +target gene 32382320 hsa-mir-146a Adenocarcinoma of Lung miR-146a suppresses the proliferation and migration of human lung adenocarcinoma cells by downregulating the expression of IRAK1 and TRAF6. +other 32382291 hsa-mir-200a Cardiomyopathies In this study, we first found that the RAS-RH antifibrosis effect was associated with the upregulation of microRNA-200a and the downregulation of TGF-beta1/smad3 and COL1alpha. +circulation_biomarker_diagnosis_ns 32382289 hsa-mir-126 Depression Mitogen-activated protein kinase (MAPK) signaling plays a critical role in the pathogenesis of CHD and can be activated by miR-126. CONCLUSIONS: Tai Chi improved CHD risk by inactivating the MAPK/ERK pathway via serum miR-126. +other 32382150 hsa-mir-185 Breast Neoplasms 5p level predicts a worse outcome in breast cancer patients receiving 5-FU-based chemotherapy. +other 32381457 hsa-mir-143 Immune System Diseases In addition, we established that miR-19a and miR-143 were significantly increased in IMID patients with severe disease (p < 0.05). +other 32381457 hsa-mir-19a Immune System Diseases In addition, we established that miR-19a and miR-143 were significantly increased in IMID patients with severe disease (p < 0.05). +circulation_biomarker_diagnosis_ns 32381094 hsa-mir-374a Asthma Alterations in expression of miR-155, -146a, -374a and - 145 were observed in allergic asthmatics in response to inhaled corticosteroid usage. Additionally, miR-223 and miR-374a expression varied in non-allergic asthmatics based on blood eosinophil numbers. +circulation_biomarker_diagnosis_ns 32381094 hsa-mir-155 Asthma Alterations in expression of miR-155, -146a, -374a and - 145 were observed in allergic asthmatics in response to inhaled corticosteroid usage. Additionally, miR-223 and miR-374a expression varied in non-allergic asthmatics based on blood eosinophil numbers. +circRNA target 32381016 hsa-mir-370 Melanoma CONCLUSIONS: Elevated circ_0020710 drives tumor progression via the miR3p/CXCL12 axis, and circ_0020710 is a potential target for melanoma treatment. +lncRNA target 32380907 hsa-mir-153 Colorectal Neoplasms mediated autophagy, indicating a new therapeutic target for CRC treatment. +genetics_knock down_promote 32380843 hsa-mir-153 Carcinoma, Non-Small-Cell Lung Conclusions: Knockdown of NEAT1 could suppress cell proliferation, migration, and invasion of NSCLC while promoting cell apoptosis through sponging miR +transcription factor target 32380833 hsa-mir-224 Carcinoma, Hepatocellular Thus, a universal cancer biomarker of miR-21 and two specific liver-cancer biomarkers (miR-199a and miR-224) are efficiently detected through a one-step detection. +transcription factor target 32380833 hsa-mir-199a Carcinoma, Hepatocellular Thus, a universal cancer biomarker of miR-21 and two specific liver-cancer biomarkers (miR-199a and miR-224) are efficiently detected through a one-step detection. +transcription factor target 32380833 hsa-mir-21 Carcinoma, Hepatocellular Thus, a universal cancer biomarker of miR-21 and two specific liver-cancer biomarkers (miR-199a and miR-224) are efficiently detected through a one-step detection. +genetics_overexpression_promote 32380791 hsa-mir-363 Acute Lymphoblastic Leukemia, T-Cell We have previously shown by miRNA-seq, that miRNAs from the mir-106a-363 cluster are overexpressed in pediatric T-ALL. +genetics_overexpression_promote 32380791 hsa-mir-106a Acute Lymphoblastic Leukemia, T-Cell We have previously shown by miRNA-seq, that miRNAs from the mir-106a-363 cluster are overexpressed in pediatric T-ALL. +other 32380791 hsa-mir-20b Acute Lymphoblastic Leukemia, T-Cell We demonstrate, for the first time, that hsa-miR-20b-5p and hsa-miR3p from the mir-106a-363 cluster, when upregulated in T-ALL cells in vitro, protect leukemic cells from apoptosis, enhance proliferation, and contribute to growth advantage. +other 32380696 hsa-mir-3157 Leukemia, Lymphocytic, Chronic, B-Cell Our results reveal that in addition to a CLL-specific expression pattern, there is also specific RNA editing of many miRNAs, particularly miR-3157 and miR-6503, in CLL. +circulation_biomarker_diagnosis_ns 32380583 hsa-mir-181a Inflammatory Bowel Diseases In this study, we aimed to investigate the role of Atg5 and microRNA-181a (miR-181a) in the pathophysiology of UC. There was no significant difference in the expression of miR-181a in the blood samples of UC and HCs. +circulation_biomarker_diagnosis_up 32380415 hsa-mir-126 Intrahepatic Cholestasis of Pregnancy RIPC seems to have neuroprotective effects by downregulating the expression of DNMTs in neural cells through the upregulation of serum exosomal miRNA-126. +circulation_biomarker_diagnosis_ns 32380415 hsa-mir-126 Myocardial Infarction Serum miRNA-126 is associated with ischemic stroke, and exosomal miRNA-126 has shown protective effects against acute myocardial infarction. +circulation_biomarker_diagnosis_ns 32380415 hsa-mir-126 Ischemic Stroke Serum miRNA-126 is associated with ischemic stroke, and exosomal miRNA-126 has shown protective effects against acute myocardial infarction. +circulation_biomarker_diagnosis_ns 32380256 hsa-mir-23a Osteoporosis 3p, in the plasma of 20 postmenopausal PHPT women. +circulation_biomarker_diagnosis_ns 32380256 hsa-mir-24-2 Osteoporosis 3p, in the plasma of 20 postmenopausal PHPT women. +circulation_biomarker_diagnosis_ns 32380256 hsa-mir-24-2 Hyperparathyroidism, Primary 3p, in the plasma of 20 postmenopausal PHPT women. +circulation_biomarker_diagnosis_ns 32380256 hsa-mir-24-2 Osteoporosis, Postmenopausal 3p, in the plasma of 20 postmenopausal PHPT women. +circulation_biomarker_diagnosis_ns 32380256 hsa-mir-23a Hyperparathyroidism, Primary 3p, in the plasma of 20 postmenopausal PHPT women. +circulation_biomarker_diagnosis_ns 32380256 hsa-mir-23a Osteoporosis, Postmenopausal 3p, in the plasma of 20 postmenopausal PHPT women. +circulation_biomarker_diagnosis_ns 32380256 hsa-mir-21 Hyperparathyroidism, Primary 3p, in the plasma of 20 postmenopausal PHPT women. +circulation_biomarker_diagnosis_ns 32380256 hsa-mir-21 Osteoporosis, Postmenopausal 3p, in the plasma of 20 postmenopausal PHPT women. +circulation_biomarker_diagnosis_ns 32380256 hsa-mir-21 Osteoporosis 3p, in the plasma of 20 postmenopausal PHPT women. +circulation_biomarker_diagnosis_ns 32380256 hsa-mir-125b Hyperparathyroidism, Primary 3p, in the plasma of 20 postmenopausal PHPT women. +circulation_biomarker_diagnosis_ns 32380256 hsa-mir-122 Hyperparathyroidism, Primary 3p, in the plasma of 20 postmenopausal PHPT women. +circulation_biomarker_diagnosis_ns 32380256 hsa-mir-122 Osteoporosis 3p, in the plasma of 20 postmenopausal PHPT women. +circulation_biomarker_diagnosis_ns 32380256 hsa-mir-122 Osteoporosis, Postmenopausal 3p, in the plasma of 20 postmenopausal PHPT women. +circulation_biomarker_diagnosis_ns 32380256 hsa-mir-148 Hyperparathyroidism, Primary 3p, in the plasma of 20 postmenopausal PHPT women. +circulation_biomarker_diagnosis_ns 32380256 hsa-mir-148 Osteoporosis 3p, in the plasma of 20 postmenopausal PHPT women. +circulation_biomarker_diagnosis_ns 32380256 hsa-mir-93 Osteoporosis, Postmenopausal In conclusion, PHPT may modulate circulating fractures-related miRNAs, in particular, miR +circulation_biomarker_diagnosis_ns 32380256 hsa-mir-125b Osteoporosis, Postmenopausal 3p, in the plasma of 20 postmenopausal PHPT women. +circulation_biomarker_diagnosis_ns 32380256 hsa-mir-125b Osteoporosis 3p, in the plasma of 20 postmenopausal PHPT women. +circulation_biomarker_diagnosis_ns 32380256 hsa-mir-93 Osteoporosis In conclusion, PHPT may modulate circulating fractures-related miRNAs, in particular, miR +circulation_biomarker_diagnosis_ns 32380256 hsa-mir-93 Hyperparathyroidism, Primary In conclusion, PHPT may modulate circulating fractures-related miRNAs, in particular, miR +circulation_biomarker_diagnosis_ns 32380256 hsa-mir-148 Osteoporosis, Postmenopausal 3p, in the plasma of 20 postmenopausal PHPT women. +other 32380144 hsa-mir-138 Brain Injury, Chronic 5p, increased. +other 32380144 hsa-mir-142 Brain Injury, Chronic 5p, increased. +other 32380144 hsa-mir-142 Neuralgia 5p, increased. +other 32380144 hsa-mir-676 Brain Injury, Chronic 5p, increased. +other 32380144 hsa-mir-676 Neuralgia 5p, increased. +other 32380144 hsa-mir-138 Neuralgia 5p, increased. +lncRNA target 32380108 hsa-mir-21 Liver Neoplasms The miRNA expression patterns of human liver cancer cells HepG2 in vivo under PRP1 treatment were established, and microRNA-21 (miR-21) as the onco-miRNA was appreciably downregulated. PRP1 repressed the expression of miR-21, which directly targeted and suppressed PTEN (a negative regulator of the PI3K/Akt signaling cascade), and subsequently upregulated the expression of PTEN but downregulated the PI3K/AKT pathway, thereby promoting liver cancer cell apoptosis. +other 32380062 hsa-let-7b Autoimmune Diseases Therefore, our comparative strategy identified TGF-beta1, PTX3, let-7b-5p, or miR5p as key molecules mediating the therapeutic effects of MSC-EVs in autoimmune disease. +other 32380062 hsa-mir-21 Autoimmune Diseases Therefore, our comparative strategy identified TGF-beta1, PTX3, let-7b-5p, or miR5p as key molecules mediating the therapeutic effects of MSC-EVs in autoimmune disease. +lncRNA target 32380055 hsa-mir-184 Liver Cirrhosis CONCLUSION: Our results indicated that HGTLF could improve liver fibrosis via down-regulating miR-184 and up-regulating of FOXO1 to inhibit Th17 cell differentiation. +genetics_overexpression_promote 32380054 hsa-mir-339 Stomach Neoplasms Overexpression of ALKBH1 was able to reverse the inhibitory effects of overexpressed miRNA +other 32380039 hsa-mir-21 Carcinoma, Hepatocellular In addition, qPCR results showed that miR-21 and miR-181a expression were upregulated in HepG2 cells treated with cancer cell -derived MVs that might support the cancer progression. +other 32380039 hsa-mir-181a Carcinoma, Hepatocellular In addition, qPCR results showed that miR-21 and miR-181a expression were upregulated in HepG2 cells treated with cancer cell -derived MVs that might support the cancer progression. +lncRNA target 32379794 hsa-mir-103 Bone Diseases CONCLUSIONS: The present results suggested that miR-103 negatively regulates SATB2 to serve an inhibitory role in the proliferation and osteogenic differentiation of HBMScs, which sheds light upon a potential therapeutic target for treating bone-related diseases. +genetics_knock down_promote 32379550 hsa-mir-520b Colorectal Neoplasms Both miR-520b overexpression and miR-302c-3p overexpression inhibited CRC cell growth. +genetics_overexpression_promote 32379497 hsa-mir-7 Uterine Cervical Neoplasms Overexpression of MEG3 or miR +lncRNA target 32379493 hsa-mir-26a Colorectal Neoplasms Conclusion: Silencing DLX6-AS1 may block the malignant features of CRC cells by inhibiting the expression of EZH2 through upregulation of miR-26a. +genetics_knock down_promote 32379482 hsa-mir-107 Breast Neoplasms The possible sponging target of KCNQ1OT1, human microRNA-107 (hsa-miR-107), was confirmed to be bound by KCNQ1OT1, and was upregulated in breast cancer cells with KCNQ1OT1 downregulation. Thus, loss of KCNQ1OT1 is associated with functional impairment in breast cancer cells, likely through inverse regulation of its sponging target, hsa-miR-107. +transcription factor target 32378978 hsa-mir-296 Cartilage Diseases 5p inhibited the progression of OA through the CTGF/p38MAPK pathway by directly targeting TGF-beta1. +circRNA target 32378344 hsa-mir-646 Endometrial Neoplasms High expression of miR-646 could reverse the effect of circWHSC1 on endometrial cancer cells. CircWHSC1 promotes endometrial cancer development through sponging miR-646 and targeting NPM1. +lncRNA target 32377998 hsa-mir-188 Cardiomegaly In summary, DSCAM-AS1 was identified as a positive modulator in cardiac hypertrophy through miR5p decoying and GRK2 augmentation, giving rise to an enriched theoretical basis for finding a promising target in cardiac hypertrophy regulation. +exosome 32377874 hsa-mir-9 Osteoarthritis To conclude, these findings suggest the anti-inflammatory and chondroprotective effects of BM-MSC-derived exosomal miR +genetics_overexpression_suppress 32377748 hsa-mir-133b Carcinoma, Renal Cell In conclusion, miR133b overexpression was observed to inhibit the proliferation, migration and invasion of renal cell carcinoma cells and improve chemotherapeutic sensitivity; it was suggested that the mechanism maybe related to the inhibition of ERK1/2 phosphorylation and thus decreased ERK signaling pathway activity. +lncRNA target 32377743 hsa-mir-193b Osteosarcoma Collectively, these findings indicated that miR193b may serve a tumor suppressive role in osteosarcoma by targeting KRAS and STMN1. +transcription factor target 32377732 hsa-mir-214 Liver Failure, Acute Therefore, the aim of the present study was to investigate the role and underlying mechanism of miR214 in ALF. Collectively, the present results suggested that miR214 inhibited hepatocyte apoptosis during ALF development via targeting Bax, thus indicating that miR214 may be a potential target for ALF treatment. +genetics_overexpression_suppress 32377722 hsa-mir-96 Uterine Cervical Neoplasms The present results suggested that overexpression of miR96 significantly enhanced the proliferative, migratory and invasive abilities of cervical cancer cells, while inhibiting miR96 had the opposite effects. +lncRNA target 32377721 hsa-mir-19b Nasopharyngeal Carcinoma Therefore, miR19b inhibition may serve as a novel therapeutic target for the treatment of NPC. +lncRNA target 32377701 hsa-mir-508 Ovarian Neoplasms To the best of our knowledge, this is the first study to demonstrated that miR5083p suppressed ovarian cancer development by directly targeting CCNA2 and MMP7. +lncRNA target 32377693 hsa-mir-499 Reperfusion Injury Ischemic postconditioning attenuates the inflammatory response in ischemia/reperfusion myocardium by upregulating miR499 and inhibiting TLR2 activation. +circulation_biomarker_diagnosis_ns 32377692 hsa-mir-638 Atherosclerosis In the serum of patients with AS and HAECs induced by oxidized lowdensity lipoprotein (oxLDL), the expression level of miR638 was decreased, whereas that of NEAT1 was increased. +genetics_overexpression_promote 32377691 hsa-mir-1 Breast Neoplasms The data from the present study demonstrated for the first time that overexpression of miR1 increases the sensitivity of breast cancer cells to paclitaxel and cisplatin. +other 32377690 hsa-mir-10a Bone Diseases In conclusion, the findings of the present study suggested that miR10a5p served as a negative regulatory factor during osteoblast differentiation of hBMSCs and may be utilized in a treatment approach for bone repair in osteogenicrelated diseases. +circulation_biomarker_diagnosis_up 32377580 hsa-mir-145 Plaque, Atherosclerotic Circulating plasma microRNA-126, microRNA-145, and microRNA-155 and their association with atherosclerotic plaque characteristics. +lncRNA target 32377580 hsa-mir-126 Plaque, Atherosclerotic Dysregulation of miRNA-126, microRNA-145, and microRNA-155 has been shown to be associated with atherosclerotic lesion formation. +lncRNA target 32377580 hsa-mir-155 Plaque, Atherosclerotic Dysregulation of miRNA-126, microRNA-145, and microRNA-155 has been shown to be associated with atherosclerotic lesion formation. +genetics_overexpression_promote 32377460 hsa-mir-375 Carcinoma, Hepatocellular 3p overexpression significantly enhanced proliferation, HBV-DNA replication, as well as the migration and invasion of HCC cells, whereas miR-375 overexpression resulted in opposite effects. +genetics_overexpression_promote 32377460 hsa-mir-375 Hepatitis B 3p overexpression significantly enhanced proliferation, HBV-DNA replication, as well as the migration and invasion of HCC cells, whereas miR-375 overexpression resulted in opposite effects. +target gene 32377191 hsa-mir-200b Ovarian Neoplasms miR-200b/200a/429 Cluster Stimulates Ovarian Cancer Development by Targeting ING5. +target gene 32377191 hsa-mir-200a Ovarian Neoplasms miR-200b/200a/429 Cluster Stimulates Ovarian Cancer Development by Targeting ING5. +target gene 32377191 hsa-mir-429 Ovarian Neoplasms miR-200b/200a/429 Cluster Stimulates Ovarian Cancer Development by Targeting ING5. +genetics_knock down_promote 32377170 hsa-mir-128 Ovarian Neoplasms In conclusion, MIR4435-2HG knockdown suppressed the progression of OC cells through downregulating CDK14 expression by the promotion of miR +other 32377170 hsa-mir-4435-2 Ovarian Neoplasms However, the underlying function of MIR4435-2HG in ovarian cancer (OC) remains unclear. +genetics_knock down_suppress 32377169 hsa-mir-129 Carcinoma, Non-Small-Cell Lung 5p knockdown on NSCLC progression. +genetics_knock down_promote 32376943 hsa-mir-145 Triple Negative Breast Neoplasms The results showed that miR-145 expression was low, whereas AFAP1-AS1 and MTH1 expression was high in TNBC cells and that miR-145 mimics reduced TNBC cell proliferation and invasion, whereas miR-145 knockdown exerted the opposite activity in TNBC cells. This study revealed that AFAP1-AS1 could promote TNBC cell proliferation and invasion via regulation of MTH1 expression through targeting of miR-145. +transcription factor target 32376822 hsa-mir-4465 Nasopharyngeal Carcinoma The results suggest that HDAC7 promotes the oncogenicity of NPC by downregulating miR-4465 and subsequently upregulating EphA2, highlighting HDAC7 as a potential therapeutic target for NPC. +exosome 32376798 hsa-mir-142 Sjogren's Syndrome 3p in SS pathogenesis and promotes the concept that T cell activation may directly impair epithelial cell function through secretion of miRNA-containing exosomes. +other 32376568 hsa-mir-34a Choriocarcinoma METHODS We examined the expression of miR-34a-5p using RT-qPCR in cultured human trophoblast HTR-8/Svneo cells and human choriocarcinoma cell lines BeWo and JEG-3HTR-8/Svneo. +genetics_overexpression_promote 32376567 hsa-mir-145 Endometrial Neoplasms CONCLUSIONS: Overexpression of miR5p inhibits the proliferation, migration and invasion and promotes apoptosis of endometrial cancer cells possibly by negative regulation of DUSP6 expression. +lncRNA target 32376557 hsa-mir-449b Stomach Neoplasms CONCLUSIONS: The low expression of miR-449a/b and the high expression of E2F1 are both involved in the occurrence and progression of gastric cancer, and miR-449a/b negatively regulates E2F1 to inhibit the proliferation of gastric cancer cells. +lncRNA target 32376557 hsa-mir-449a Stomach Neoplasms CONCLUSIONS: The low expression of miR-449a/b and the high expression of E2F1 are both involved in the occurrence and progression of gastric cancer, and miR-449a/b negatively regulates E2F1 to inhibit the proliferation of gastric cancer cells. +transcription factor target 32376551 hsa-mir-671 Breast Neoplasms 3p suppresses the proliferation and invasion of breast cancer cell line MCF-7 by directly targeting DEPTOR protein. +genetics_overexpression_suppress 32376451 hsa-mir-224 Stomach Neoplasms Upregulation of USP3 restored MKN-28 and MGC-803 cell proliferation and migration after overexpression of miR +transcription factor target 32376266 hsa-mir-214 Keloid 5p, and TM4SF1 are involved in proliferation, cell motility, and apoptosis, suggesting that they may be potential targets in therapies for keloids. +transcription factor target 32376266 hsa-mir-1 Keloid 5p, and TM4SF1 are involved in proliferation, cell motility, and apoptosis, suggesting that they may be potential targets in therapies for keloids. +lncRNA target 32376265 hsa-mir-206 Colonic Neoplasms Furthermore, miR-206 targets ANXA2 and plays a role as a cancer suppressor in colonic adenocarcinoma. SIGNIFICANCE: Our study provided evidence that further elucidates the molecular mechanism of ANXA2 and its roles in colonic adenocarcinoma and suggested potential targets of ANXA2 for colonic adenocarcinoma therapy by using miR-206 as a novel strategy. +genetics_overexpression_suppress 32376241 hsa-mir-551b Squamous Cell Carcinoma of Head and Neck The effects of overexpressing miR-551b on the proliferation, migration, and invasion of OSCC cells were examined using Cell Counting Kit 8 (Dojindo, Kumamoto, Japan), plate clone formation, wound healing, and Transwell invasion experiments (Corning, Corning, NY). +lncRNA target 32375892 hsa-mir-153 Adenocarcinoma of Lung CONCLUSION: MiR-153 suppresses the stem cell-like phenotypes and tumor growth of lung adenocarcinoma by targeting Jagged1 and provides a potential therapeutic target in lung cancer therapy. +lncRNA target 32375838 hsa-mir-125 Hypoxia-Ischemia, Brain, Newborn CONCLUSIONS: IRE1alpha inhibitor, STF083010, reduced neuronal pyroptosis at least in part via miR-125/NLRP1/caspase-1 signaling pathway after HI. +transcription factor target 32375686 hsa-mir-885 Esophageal Squamous Cell Carcinoma RESULTS: Thirty-nine miRNAs were identified whose tumor/normal tissue expression ratios showed dysregulation (28 down- and 11 up-regulated by at least two-fold with P < 1.92E-04), including several not previously reported in ESCC (miR +transcription factor target 32375686 hsa-mir-885 Esophageal Neoplasms RESULTS: Thirty-nine miRNAs were identified whose tumor/normal tissue expression ratios showed dysregulation (28 down- and 11 up-regulated by at least two-fold with P < 1.92E-04), including several not previously reported in ESCC (miR +transcription factor target 32375686 hsa-mir-708 Esophageal Neoplasms RESULTS: Thirty-nine miRNAs were identified whose tumor/normal tissue expression ratios showed dysregulation (28 down- and 11 up-regulated by at least two-fold with P < 1.92E-04), including several not previously reported in ESCC (miR +transcription factor target 32375686 hsa-mir-708 Esophageal Squamous Cell Carcinoma RESULTS: Thirty-nine miRNAs were identified whose tumor/normal tissue expression ratios showed dysregulation (28 down- and 11 up-regulated by at least two-fold with P < 1.92E-04), including several not previously reported in ESCC (miR +transcription factor target 32375686 hsa-mir-140 Esophageal Neoplasms RESULTS: Thirty-nine miRNAs were identified whose tumor/normal tissue expression ratios showed dysregulation (28 down- and 11 up-regulated by at least two-fold with P < 1.92E-04), including several not previously reported in ESCC (miR +transcription factor target 32375686 hsa-mir-140 Esophageal Squamous Cell Carcinoma RESULTS: Thirty-nine miRNAs were identified whose tumor/normal tissue expression ratios showed dysregulation (28 down- and 11 up-regulated by at least two-fold with P < 1.92E-04), including several not previously reported in ESCC (miR +transcription factor target 32375631 hsa-mir-215 Neurotoxicity Syndromes CONCLUSION: Taken together, we demonstrate that miR-215 attenuates propofol-induced apoptosis and oxidative stress in neonatal rat hippocampal neuron by targeting LATS2, suggesting that miR-215 may provide a new candidate for the treatment of propofol exposure-induced neurotoxicity. +lncRNA target 32375449 hsa-mir-524 Osteosarcoma Conclusions: Long non-coding RNA LINC-PINT can inhibit the proliferation and promote apoptosis of osteosarcoma cells through targeting miR +transcription factor target 32375447 hsa-mir-451 Colorectal Neoplasms Objective: To investigate the effect and mechanism of miR-451 on the proliferation and migration of human colorectal cancer cell SW480 by targeting macrophage migration inhibitory factor (MIF). Conclusion: MiR-451 may regulate proliferation and migration of human colorectal cancer cells by targeting MIF. +other 32374895 hsa-mir-183 Peripheral Arterial Disease First, RNA sequencing analysis of 15 healthy and 16 PAD samples showed that 524 PAD differential genes were significantly enriched in Go Ontology (ribonucleotide metabolic process, oxidoreductase complex, and electron transfer activity), Kyoto Encyclopedia of Genes and Genomes (KEGG) and GSEA pathways (OXPHOS and TCA cycle), miRNA (MIR183), and kinase (PAK6). +exosome 32374679 hsa-let-7a Cartilage Diseases Experiments were performed to verify the potential target Smad2 and investigate how let-7a-5p affected chondrocytes. Moreover, osteoclast-derived exosomal let-7a-5p inhibits Smad2 to decrease the transforming growth factor-beta-induced inhibition of chondrocyte hypertrophy. +genetics_knock down_suppress 32374522 hsa-mir-449b Breast Neoplasms Functionally, HOTAIR conferred decreased radiosensitivity on BRCA cells, while miR-449b-5p overexpression or HSPA1A knockdown abrogated the HOTAIR-enhanced BRCA growth under the irradiation exposure both in vitro and in vivo. CONCLUSIONS: LncRNA HOTAIR facilitates the expression of HSPA1A by sequestering miR-449b-5p post-transcriptionally and thereby endows BRCA with radiation resistance. +transcription factor target 32374403 hsa-mir-27b Inflammation mRNA potential targets of differentially expressed-miRNA were investigated, and genes related to pain and inflammation were identified: miR-19b potentially modulates TGF-beta and focal adhesion pathways, miR-365 regulates cytokines expression (i.e., IL-1, Tumor Necross Factor-alpha, and IL-8 cytokine), and miR-27b regulates macrophage inflammatory protein pathways (i.e., MIP1-beta). +transcription factor target 32374403 hsa-mir-365 Inflammation mRNA potential targets of differentially expressed-miRNA were investigated, and genes related to pain and inflammation were identified: miR-19b potentially modulates TGF-beta and focal adhesion pathways, miR-365 regulates cytokines expression (i.e., IL-1, Tumor Necross Factor-alpha, and IL-8 cytokine), and miR-27b regulates macrophage inflammatory protein pathways (i.e., MIP1-beta). +transcription factor target 32374403 hsa-mir-19b Inflammation mRNA potential targets of differentially expressed-miRNA were investigated, and genes related to pain and inflammation were identified: miR-19b potentially modulates TGF-beta and focal adhesion pathways, miR-365 regulates cytokines expression (i.e., IL-1, Tumor Necross Factor-alpha, and IL-8 cytokine), and miR-27b regulates macrophage inflammatory protein pathways (i.e., MIP1-beta). +genetics_knock down_promote 32374006 hsa-mir-30 Osteoporosis CONCLUSIONS: Knockdown of miR +other 32373982 hsa-mir-129 Myocardial Reperfusion Injury 5p plays a protective role on myocardial I/R injury by regulating HMGB1 expression. +circulation_biomarker_prognosis_up 32373978 hsa-mir-584 Lymphoma, Nk-T-Cell RESULTS: Peripheral blood levels of miRNA-584 were lower in NK/T-cell lymphoma patients than those of healthy control. +genetics_overexpression_promote 32373971 hsa-mir-9501 Breast Neoplasms Subsequently, microRNA-9501 overexpression model was constructed in BCa cell lines MCF-7 and MDA-MB-231. +other 32373969 hsa-mir-1324 Squamous Cell Carcinoma of Head and Neck Dual-Luciferase reporter assay was conducted to verify that circ_0067934 may sponge miR-1324 to regulate proliferation and migration of LSCC. Mechanism analysis revealed that circ_0067934 regulated LSCC development by sponging miR-1324. +other 32373967 hsa-mir-142 Lung Neoplasms 5p induces the resistance of lung cancer PC9 cells to gefitinib by upregulating HOXD8. +lncRNA target 32373966 hsa-mir-593 Adenocarcinoma of Lung 5p/ICAM-1 axis might be a potential therapeutic target for the diagnosis and treatment of LA. +genetics_knock down_promote 32373965 hsa-mir-597 Carcinoma, Non-Small-Cell Lung Similarly, compared with NC group, the proliferation ability of NSCLC cells was remarkably weakened in microRNA-597 overexpression group (p<0.05). +other 32373964 hsa-mir-204 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: LncRNA AWPPH serves as the miRNA-204 sponge to upregulate CDK6 level, thus aggravating the progression of NSCLC. +circRNA target 32373963 hsa-mir-5112 Carcinoma, Non-Small-Cell Lung The purpose of this study is to investigate the expression of circRNA_001010 and its facilitating effects on proliferation and invasion of non-small cell lung cancer (NSCLC) by regulating oncogene CDK4 through sponging with miR-5112. CONCLUSIONS: For the first time, we found that circRNA_001010 was upregulated in human NSCLC patients, which could accelerate tumor proliferation, migration and invasion as a molecular sponge by modulating the inhibitory effect of miR-5112 on oncogene CDK4. +transcription factor target 32373961 hsa-mir-802 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: MiR-802 suppresses the malignant biological behavior of OSCC by targeting proto-oncogene MET. +lncRNA target 32373959 hsa-mir-124 Stomach Neoplasms 3p/EZH2 signaling axis in promoting cell proliferation and invasion in GC patients and GC cell lines, which suggested that it might be a potential target for treating human GC. +genetics_overexpression_promote 32373957 hsa-mir-493 Colorectal Neoplasms 5p overexpression. +genetics_overexpression_promote 32373956 hsa-mir-5195 Colorectal Neoplasms In addition, it was demonstrated that overexpression of miR-5195 inhibited CRC progression. CONCLUSIONS: Our study revealed that ST8SIA6-AS1 promoted CRC progression via the miR-5195/PCBP2 axis. +circRNA target 32373955 hsa-mir-206 Colorectal Neoplasms We found that circ_0056618 could promote cell proliferation, migration and angiogenesis through sponging with miR-206 and upregulating CXCR4 and VEGF-A in CRC, which might provide a novel potential therapeutic target for treating CRC. +genetics_overexpression_promote 32373952 hsa-mir-103a Carcinoma, Hepatocellular CONCLUSIONS: Overexpression of hsa_circ_0000711 promoted the proliferation and inhibited the apoptosis of hepatoma cells via targeting has-miR-103a-3p. +lncRNA target 32373949 hsa-mir-19b Uterine Cervical Neoplasms Furthermore, we firstly uncovered that PTENP1 could inhibit cell proliferation and invasion via miR-19b/MTUS1 in CC patients, which uncovered the tumor-suppressive role of PTENP1 in CC and suggested that it might be a potential target for treating human CC. +lncRNA target 32373947 hsa-mir-489 Ovarian Neoplasms Moreover, we found that miR-489 inhibits OC progression via regulating phosphatidyl-inositol 3-kinase/protein kinase B pathway (PI3K/AKT) and epithelial-to-mesenchymal transition (EMT). +lncRNA target 32373944 hsa-mir-19a Femoral Neck Fractures CONCLUSIONS: LncRNA HAGLR/miRNA-19a-3p/TGFBR2 regulatory loop accelerates the healing process of femoral neck fracture by inhibiting the TGF-beta pathway. +lncRNA target 32373367 hsa-mir-21 Breast Neoplasms Thus, to identify novel metastatic markers, we evaluated the expression levels of AR; miR-185 and miR-205, both of which have been confirmed to target AR; and miR-21, transcription of which is regulated by AR, in breast cancer samples (n = 89). +lncRNA target 32373367 hsa-mir-205 Breast Neoplasms Thus, to identify novel metastatic markers, we evaluated the expression levels of AR; miR-185 and miR-205, both of which have been confirmed to target AR; and miR-21, transcription of which is regulated by AR, in breast cancer samples (n = 89). +lncRNA target 32373221 hsa-mir-141 Arthritis, Rheumatoid 3p bound to the FoxC1 3'UTR and suppressed FoxC1 expression. +lncRNA target 32373215 hsa-mir-1 Carcinoma, Hepatocellular 5p as potential therapeutic targets in HCC. +transcription factor target 32373208 hsa-mir-130b Carcinoma, Hepatocellular Conclusions: This study showed that a dysregulation in the Sp1/miR-130b-3p/HOXA5 axis contributed to HCC progression and angiogenesis, and that HOXA5 can be considered as a promising therapeutic target for treating HCC. +other 32373058 hsa-mir-206 Muscular Dystrophy, Duchenne MiR-30c and miR-206 represent sensitive biomarkers for DMD, while miR-206 may have an additional value to distinguish the DMD and BMD phenotype. +circulation_biomarker_diagnosis_ns 32372456 hsa-mir-137 Periodontitis In the current study, we assessed the expression of four lncRNAs (BDNF-AS, MIAT, MIR137HG, and PNKY) as well as BDNF in the peripheral blood and gingival tissues obtained from patients with periodontitis and healthy subjects. +lncRNA target 32372405 hsa-mir-7 Breast Neoplasms Similarly, in vivo results suggesting that CXCR4 inhibitors can reverse the EMT phenotype of drug-resistant breast cancer cells through the CXCR4/miR +lncRNA target 32372307 hsa-mir-494 Breast Neoplasms CONCLUSION: Taken together, these results suggest that miR-494 plays a role in the mechanism of BC resistance to trastuzumab by involving its target genes CNR1, RBM39, and ZNF207. +other 32372215 hsa-mir-210 Squamous Cell Carcinoma of Head and Neck This study aims to determine the effect of melatonin in improving the clinical response of patients with locally advanced oral squamous cell carcinoma (OSCC) after neoadjuvant chemotherapy to miR-210 and CD44 expression. CONCLUSION In OSCC, the addition of 20-mg melatonin to neoadjuvant chemotherapy (NC) reduced the expression of miR-210 and CD44 and decreased the percentage of tumor residue; however, no statistically significant result was observed. +other 32372074 hsa-mir-155 Atherosclerosis These results lay the groundwork for future research on the therapeutic potential of miR-155 against atherosclerosis-associated cardiovascular diseases. +genetics_overexpression_promote 32372060 hsa-mir-1258 Carcinoma, Hepatocellular MiR-1258 overexpression inhibited migration and invasion of HCC cells both in vitro and in vivo, whereas miR-1258 downregulation promoted cell metastasis. +transcription factor target 32371982 hsa-mir-1269b Carcinoma, Hepatocellular Bioinformatic analysis and RT-PCR results showed that miR-1269b expression is negatively correlated with the SVEP1 expression and the prognosis of HCC patients. MiR-1269b downregulates SVEP1 expression and promotes HCC proliferation and metastasis likely through the PI3k/Akt signaling pathway. +other 32371926 hsa-mir-125a Pancreatic Carcinoma The correlation model consisting of miR-125a-3p, miR-5100 and miR-642b-3p was the most promising model in the diagnosis of PC patients from healthy controls with an AUC of 0.95, Sensitivity 0.98 and Specificity 0.97. +other 32371926 hsa-mir-5100 Pancreatic Carcinoma The correlation model consisting of miR-125a-3p, miR-5100 and miR-642b-3p was the most promising model in the diagnosis of PC patients from healthy controls with an AUC of 0.95, Sensitivity 0.98 and Specificity 0.97. +other 32371926 hsa-mir-642b Pancreatic Carcinoma The correlation model consisting of miR-125a-3p, miR-5100 and miR-642b-3p was the most promising model in the diagnosis of PC patients from healthy controls with an AUC of 0.95, Sensitivity 0.98 and Specificity 0.97. +lncRNA target 32371581 hsa-mir-622 Ovarian Neoplasms These wide-ranging antitumor properties of miR-3622b-5p in ovarian cancer cells are mimicked by the associations of pharmacologic inhibitors targeting these proteins. +lncRNA target 32370988 hsa-mir-124 Adenocarcinoma of Lung CONCLUSION: Our current study suggested that miR-124 was a tumor suppressor in LA, and miR-124 was associated with LA cell EMT phenotype formation via targeting EZH2. +lncRNA target 32370947 hsa-mir-27a Cardiomegaly Bioinformatic analysis revealed that PDZ and LIM domain 5 (PDLIM5) is one of the major targets of miRNA-27a*, playing a major role in cardiac structure and function, and potentially contributing to the progression of cardiac hypertrophy. These findings suggest that cardiac fibroblast-secretion of miRNA27a*-enriched EVs may act as a paracrine signaling mediator of cardiac hypertrophy that has potential as a novel therapeutic target. +other 32370743 hsa-mir-18b Triple Negative Breast Neoplasms These results suggest that miR-18a and miR-18b may play a role in the systemic immunological response in ER(-) tumours. +other 32370743 hsa-mir-18a Triple Negative Breast Neoplasms METHODS: We investigated the expression and localization of miR-18a and -18b in formalin fixed paraffin embedded (FFPE) tissue from lymph node negative breast cancers (n = 40), by chromogenic in situ hybridization (CISH). +lncRNA target 32370736 hsa-mir-514a Nasopharyngeal Carcinoma In the end, rescue assays demonstrated that the miR-514a-5p deficiency restored the NPC progression inhibited by SNHG7 silence, and ELAVL1 partly counteracted the restoration caused by miR-514a-5p inhibitor in HNE1 cells. CONCLUSIONS: LncRNA SNHG7 promotes the proliferation and migration of nasopharyngeal carcinoma by miR-514a-5p/ ELAVL1 axis. +other 32370715 hsa-mir-496 Brain Injuries miR-496 could regulate cerebral injury, while the roles of miR- 496 in neurotoxicity were not elucidated. +genetics_overexpression_promote 32370714 hsa-mir-26b Myocardial Infarction Animal experiments further indicated that miR-26b overexpression inhibited MIinduced rat MF by inhibiting the expression of HMGA2 (P<0.05, P<0.01). +genetics_overexpression_promote 32370714 hsa-mir-26b Pulmonary Fibrosis Animal experiments further indicated that miR-26b overexpression inhibited MIinduced rat MF by inhibiting the expression of HMGA2 (P<0.05, P<0.01). +genetics_knock down_promote 32370485 hsa-mir-23a Hypertrophy Objective: To investigate if microRNA (miR) -23a knockdown could attenuate angiotensin (Ang) induced cardiac hypertrophy by activating phosphatase and tensin homolog deleted on chromosome ten(PTEN) and AMP-activated protein kinase(AMPK) pathway. +other 32370169 hsa-mir-126 Angina Pectoris, Variant 3p differed between the AA group and the ICL group. +other 32370169 hsa-mir-92a Angina Pectoris, Variant 3p differed between the AA group and the ICL group. +other 32370169 hsa-mir-17 Angina Pectoris, Variant 3p differed between the AA group and the ICL group. +lncRNA target 32370060 hsa-mir-143 Breast Neoplasms We hypothesized that miR-143 suppresses breast cancer progression by targeting KRAS and its effector molecules. +genetics_knock down_promote 32369777 hsa-mir-769 Retinoblastoma 5p or restoration of STAT3 almost completely reversed the effects of LINC00324 knockdown on RB cells. +lncRNA target 32369647 hsa-mir-204 Aortic Valve Disease Taken together, our results suggest that melatonin ameliorates aortic valve calcification via the regulation of CircRIC3/miR5p/DPP4 signaling in hVICs; therefore, melatonin medication might be considered a novel pharmaceutical strategy for CAVD treatment. +transcription factor target 32369495 hsa-mir-193 Esophageal Squamous Cell Carcinoma In vitro experiments showed that miRNA193 can regulate the cell cycle of esophageal cancer cells and inhibit apoptosis, so that sensitive cells can acquire resistance to cisplatin. +transcription factor target 32369253 hsa-mir-16 Myocarditis miR-16, as an upstream regulator of DOCK2, exhibited lower expression in LPS-induced myocarditis model. Herein, our results highlighted that upregulation of miR-16 resulted in the protective effects on LPS-induced myocardial injury by reducing DOCK2 expression, affording a pair of novel target molecules for ameliorating the symptoms of myocarditis. +transcription factor target 32369253 hsa-mir-16 Cardiomyopathies However, an increasing expression of DOCK2 inhibited the remission of LPS-induced myocardial injury caused by miR-16 mimic. Herein, our results highlighted that upregulation of miR-16 resulted in the protective effects on LPS-induced myocardial injury by reducing DOCK2 expression, affording a pair of novel target molecules for ameliorating the symptoms of myocarditis. +genetics_knock down_promote 32369227 hsa-mir-103a Sepsis In conclusion, interfering miR-103a-3p or overexpression of FBXW7 improved LPS-induced septic liver injury by suppressing apoptosis, inflammation, and oxidative reaction. +genetics_knock down_promote 32369227 hsa-mir-103a Liver Injury In conclusion, interfering miR-103a-3p or overexpression of FBXW7 improved LPS-induced septic liver injury by suppressing apoptosis, inflammation, and oxidative reaction. +lncRNA target 32368989 hsa-mir-1297 Urinary Bladder Neoplasms Meanwhile, over-expression of circ 001418 induced EphA2 and cytochrome c protein expression, and suppressed FADD protein expression in vitro model of bladder carcinoma by the suppression of miR-1297. +genetics_knock down_promote 32368853 hsa-mir-499a Glioma Knockdown of ZNRD1-AS1 inhibits vasculogenic mimicry in glioma cells by modulating miR-499a-5p. +target gene 32368615 hsa-mir-532 Prostatic Neoplasms Ectopic Expression of miR-532-3p Suppresses Bone Metastasis of Prostate Cancer Cells via Inactivating NF-κB Signaling. +circRNA target 32368390 hsa-mir-149 Thyroid Cancer, Papillary In conclusion, circEIF3I upregulation in PTC tissues facilitates KIF2A expression by inhibiting miR-149, leading to malignant progression of PTC. +other 32368389 hsa-mir-216a Pancreatic Carcinoma In conclusion, the newly identified miR-216a/TSPAN1/ITGA2 axis is involved in the modulation of PC progression and represents a novel therapeutic strategy for future pancreatic cancer treatment. +other 32368326 hsa-mir-654 Colonic Neoplasms 5p and downregulated miR-376b-3p may be associated with tumour progression in colon cancer, and these microRNAs may serve as independent prognostic markers for colon cancer. +other 32368326 hsa-mir-376b Colonic Neoplasms 5p and downregulated miR-376b-3p may be associated with tumour progression in colon cancer, and these microRNAs may serve as independent prognostic markers for colon cancer. +lncRNA target 32368318 hsa-mir-124 Stomach Neoplasms 3p/PDK4 axis, which may be a promising therapeutic target for GC. +other 32368317 hsa-mir-224 Hepatitis B RESULTS: The levels of miR-375, miR-122 and miR-143 were significantly lower in HBV cirrhosis tissues, while miR-224 was significantly higher than in the controls (P < 0.0001). CONCLUSION: The four miRNAs (miR-375, miR-122, miR-143 and miR-224) may be helpful for early diagnosis of HBV infection, HBV cirrhosis, and prediction of its overall survival. +other 32368317 hsa-mir-224 Carcinoma, Hepatocellular RESULTS: The levels of miR-375, miR-122 and miR-143 were significantly lower in HBV cirrhosis tissues, while miR-224 was significantly higher than in the controls (P < 0.0001). CONCLUSION: The four miRNAs (miR-375, miR-122, miR-143 and miR-224) may be helpful for early diagnosis of HBV infection, HBV cirrhosis, and prediction of its overall survival. +other 32368317 hsa-mir-143 Hepatitis B RESULTS: The levels of miR-375, miR-122 and miR-143 were significantly lower in HBV cirrhosis tissues, while miR-224 was significantly higher than in the controls (P < 0.0001). CONCLUSION: The four miRNAs (miR-375, miR-122, miR-143 and miR-224) may be helpful for early diagnosis of HBV infection, HBV cirrhosis, and prediction of its overall survival. +other 32368317 hsa-mir-143 Carcinoma, Hepatocellular RESULTS: The levels of miR-375, miR-122 and miR-143 were significantly lower in HBV cirrhosis tissues, while miR-224 was significantly higher than in the controls (P < 0.0001). CONCLUSION: The four miRNAs (miR-375, miR-122, miR-143 and miR-224) may be helpful for early diagnosis of HBV infection, HBV cirrhosis, and prediction of its overall survival. +other 32368317 hsa-mir-122 Carcinoma, Hepatocellular RESULTS: The levels of miR-375, miR-122 and miR-143 were significantly lower in HBV cirrhosis tissues, while miR-224 was significantly higher than in the controls (P < 0.0001). CONCLUSION: The four miRNAs (miR-375, miR-122, miR-143 and miR-224) may be helpful for early diagnosis of HBV infection, HBV cirrhosis, and prediction of its overall survival. +other 32368317 hsa-mir-375 Hepatitis B RESULTS: The levels of miR-375, miR-122 and miR-143 were significantly lower in HBV cirrhosis tissues, while miR-224 was significantly higher than in the controls (P < 0.0001). CONCLUSION: The four miRNAs (miR-375, miR-122, miR-143 and miR-224) may be helpful for early diagnosis of HBV infection, HBV cirrhosis, and prediction of its overall survival. +other 32368317 hsa-mir-375 Carcinoma, Hepatocellular RESULTS: The levels of miR-375, miR-122 and miR-143 were significantly lower in HBV cirrhosis tissues, while miR-224 was significantly higher than in the controls (P < 0.0001). CONCLUSION: The four miRNAs (miR-375, miR-122, miR-143 and miR-224) may be helpful for early diagnosis of HBV infection, HBV cirrhosis, and prediction of its overall survival. +other 32368317 hsa-mir-122 Hepatitis B RESULTS: The levels of miR-375, miR-122 and miR-143 were significantly lower in HBV cirrhosis tissues, while miR-224 was significantly higher than in the controls (P < 0.0001). CONCLUSION: The four miRNAs (miR-375, miR-122, miR-143 and miR-224) may be helpful for early diagnosis of HBV infection, HBV cirrhosis, and prediction of its overall survival. +target gene 32368305 hsa-mir-658 Breast Neoplasms circNFIC suppresses breast cancer progression by sponging miR-658. +other 32368293 hsa-mir-195 Prostatic Neoplasms 3p) comparing young PCa tumoral tissue compared to normal counterpart. +other 32368293 hsa-mir-146b Prostatic Neoplasms 3p, hsa-let-7f-5p, hsa-miR-184, hsa-miR-373, hsa-miR-146b-5p) showed differences in the expression compared to LO-PCa. +other 32368293 hsa-mir-888 Prostatic Neoplasms 3p) comparing young PCa tumoral tissue compared to normal counterpart. +other 32368293 hsa-mir-600 Prostatic Neoplasms 3p) comparing young PCa tumoral tissue compared to normal counterpart. +other 32368293 hsa-mir-142 Prostatic Neoplasms 3p) comparing young PCa tumoral tissue compared to normal counterpart. +other 32368293 hsa-mir-137 Prostatic Neoplasms 3p) comparing young PCa tumoral tissue compared to normal counterpart. +other 32368293 hsa-mir-25 Prostatic Neoplasms 3p) comparing young PCa tumoral tissue compared to normal counterpart. +other 32368293 hsa-mir-29b Prostatic Neoplasms 3p, hsa-let-7f-5p, hsa-miR-184, hsa-miR-373, hsa-miR-146b-5p) showed differences in the expression compared to LO-PCa. +other 32368293 hsa-mir-373 Prostatic Neoplasms 3p, hsa-let-7f-5p, hsa-miR-184, hsa-miR-373, hsa-miR-146b-5p) showed differences in the expression compared to LO-PCa. +other 32368293 hsa-mir-124 Prostatic Neoplasms 3p, hsa-let-7f-5p, hsa-miR-184, hsa-miR-373, hsa-miR-146b-5p) showed differences in the expression compared to LO-PCa. +other 32368293 hsa-mir-9 Prostatic Neoplasms 3p, hsa-let-7f-5p, hsa-miR-184, hsa-miR-373, hsa-miR-146b-5p) showed differences in the expression compared to LO-PCa. +other 32368293 hsa-mir-184 Prostatic Neoplasms 3p, hsa-let-7f-5p, hsa-miR-184, hsa-miR-373, hsa-miR-146b-5p) showed differences in the expression compared to LO-PCa. +other 32368293 hsa-mir-663a Prostatic Neoplasms 3p) comparing young PCa tumoral tissue compared to normal counterpart. +other 32368293 hsa-mir-21 Prostatic Neoplasms 3p) comparing young PCa tumoral tissue compared to normal counterpart. +other 32368293 hsa-mir-548ai Prostatic Neoplasms 3p) comparing young PCa tumoral tissue compared to normal counterpart. +other 32368293 hsa-mir-1973 Prostatic Neoplasms 3p) comparing young PCa tumoral tissue compared to normal counterpart. +other 32368293 hsa-mir-146a Prostatic Neoplasms 3p, hsa-let-7f-5p, hsa-miR-184, hsa-miR-373, hsa-miR-146b-5p) showed differences in the expression compared to LO-PCa. +other 32368293 hsa-let-7f Prostatic Neoplasms 3p, hsa-let-7f-5p, hsa-miR-184, hsa-miR-373, hsa-miR-146b-5p) showed differences in the expression compared to LO-PCa. +other 32368293 hsa-mir-140 Prostatic Neoplasms 3p, hsa-let-7f-5p, hsa-miR-184, hsa-miR-373, hsa-miR-146b-5p) showed differences in the expression compared to LO-PCa. +other 32368197 hsa-mir-27b Venous Thrombosis 3p (P = 0.049) with VT recurrence, the observations at the latter two miRNAs confirming the recent findings of Wang et al. +other 32368197 hsa-mir-222 Venous Thrombosis 3p (P = 0.049) with VT recurrence, the observations at the latter two miRNAs confirming the recent findings of Wang et al. +other 32368197 hsa-mir-370 Venous Thrombosis 3p (P = 0.049) with VT recurrence, the observations at the latter two miRNAs confirming the recent findings of Wang et al. +lncRNA target 32368189 hsa-mir-1197 Lung Neoplasms Also explored the effect of regulation of the RIPK1 gene via rs17548629 and microRNA-1197 on the occurrence of LC. +lncRNA target 32368184 hsa-mir-524 Nasopharyngeal Carcinoma 5p to increase NR4A2 expression, indicating MSC-AS1 as a novel target for the lncRNA-targeted therapy in NPC. +genetics_overexpression_suppress 32368152 hsa-mir-196a Stomach Neoplasms MGC803 cells were transfected with miR-196a-5p mimic and inhibitor vectors for the overexpression and downregulation of miR-196a-5p, respectively. +lncRNA target 32368147 hsa-mir-26a Laryngeal Neoplasms Finally, the DLX6-AS1/miR-26a/TRPC3 axis modulated laryngeal cancer proliferation both in vitro and in vivo. CONCLUSION: This study provides new evidence that a novel lncRNA, DLX6-AS1, regulates mitochondrial calcium homeostasis, respiration and tumor proliferation via modulating the miR-26a/TRPC3 axis in laryngeal cancer. +lncRNA target 32368143 hsa-mir-1248 Esophageal Squamous Cell Carcinoma Furthermore, we found that UPK1A-AS1 exerts its anti-cancer effects partially through sponging miR-1248 in ESCC cells. +other 32368137 hsa-mir-29b Carcinoma, Non-Small-Cell Lung RESULTS: In NSCLC tissue and its cell line, miR-29b-3p was downregulated and COL1A1 was upregulated (P<0.05). +lncRNA target 32368099 hsa-mir-1224 Pancreatic Carcinoma 5p serves as a tumor suppressor and inhibits malignant behaviors of pancreatic cancer based on in vivo and in vitro assays. +genetics_overexpression_promote 32368097 hsa-mir-30 Stomach Neoplasms Overexpressed miR-330-3p can promote cell EMT, proliferation, invasion and apoptosis through inhibiting PRRX1-mediated Wnt/β-catenin signaling pathway, which is expected to be a potential therapeutic target for GC. +target gene 32368095 hsa-mir-934 Pancreatic Neoplasms miR-934 as a Prognostic Marker Facilitates Cell Proliferation and Migration of Pancreatic Tumor by Targeting PROX1. +exosome 32368088 hsa-mir-2355 Chondrosarcoma Exosomal lncRNA RAMP2-AS1 Derived from Chondrosarcoma Cells Promotes Angiogenesis Through miR-2355-5p/VEGFR2 Axis. +target gene 32368085 hsa-mir-124 Uterine Cervical Neoplasms Long Non-Coding RNA-NEAT1 Promotes Cell Migration and Invasion via Regulating miR-124/NF-κB Pathway in Cervical Cancer. +lncRNA target 32368083 hsa-mir-148b Colorectal Neoplasms CONCLUSION: Silencing of LINC00346 inhibited the proliferation, migration and invasion, and promoted the apoptosis of CRC cells through targeting miR-148b. +genetics_overexpression_suppress 32368056 hsa-mir-92b Glioblastoma RESULTS: SNA-Liposomes of about 30-50 nm in diameter internalized U87 GBM cells and inhibited the expression of miRNA-92b, an aberrantly overexpressed miRNA in GBM cell lines and GBM tumors. +exosome 32368046 hsa-mir-143 Myocardial Infarction Moreover, microarray assays demonstrated that miRNA-143 was significantly decreased in MI-exosome. +lncRNA target 32367630 hsa-mir-378a Uterine Cervical Neoplasms CONCLUSIONS: LINC00641 suppressed the progression of CC by targeting miR-378a-3p/CPEB3, suggesting that LINC00641 may have positive therapeutic impact for treatment for CC. +lncRNA target 32367412 hsa-mir-10b Atherosclerosis Overall, our study demonstrated that SMILR participated in the progression of AS by targeting the miR-10b-3p/KLF5 axis, which may provide some clues for future studies of AS. +other 32367399 hsa-mir-20 Insulin Resistance In IR adipocytes, miR320 expression is over-expressed which can be down-regulated by Metformin treatment. +lncRNA target 32366870 hsa-mir-744 Sjogren's Syndrome 5p may be a potential therapeutic target for the management of severe dry eye disease and ocular inflammation in pSS patients. +circRNA target 32366862 hsa-mir-583 Intervertebral Disc Degeneration In conclusion, the present study revealed that circ-FAM169A promotes IDD development via miR-583/BTRC signaling. +target gene 32366853 hsa-mir-93 Pancreatic Neoplasms MiR-93 is related to poor prognosis in pancreatic cancer and promotes tumor progression by targeting microtubule dynamics. +exosome 32366676 hsa-mir-182 Glioblastoma In our study, we found that, compared with the parental cells under normoxic conditions, the GBM cells produced more exosomes, and miR5p was significantly upregulated in the exosomes from GBM cells under hypoxic conditions. +circulation_biomarker_prognosis_ns 32366560 hsa-mir-122 Carcinoma, Hepatocellular RESULTS: Serum miR-122 expression had no significant difference between patients with HCC (HCC patients) and healthy controls (HCs), whereas serum miR-199a expression was significantly lower in HCC patients than the HCs (p<0.05). +transcription factor target 32366555 hsa-mir-1247 Astrocytoma 5p functions as a tumor suppressor in human astroglioma U251 cells via the miR +other 32366479 hsa-mir-199a Glioblastoma In differentiated GBM cells, ERK-mediated repression of miR-199a-3p induced EGR1 protein expression and triggered dedifferentiation. +other 32366447 hsa-mir-21 Rectal Neoplasms CONCLUSION: miRNA-21 is differentially expressed in recurrent rectal cancer tissue and healthy tissues. +transcription factor target 32366289 hsa-mir-185 Breast Neoplasms 5p via inducing apoptosis in breast cancer cells. +lncRNA target 32366274 hsa-mir-145 Carcinoma, Ovarian Epithelial 5p serves as a malignancy repressor and exerts an essential impact on inhibiting malignancy generation and reinforcing EOC death via targeting SMAD4. +circRNA target 32366257 hsa-mir-486 Pancreatic Carcinoma Moreover, circNFIB1 attenuated the oncogenic effect of miR5p and consequently upregulated PIK3R1 expression, which further downregulated VEGF-C expression through inhibition of the PI3K/Akt pathway, and ultimately suppressed lymphangiogenesis and LN metastasis in PDAC. +genetics_overexpression_promote 32366240 hsa-mir-185 Prostatic Neoplasms Prostatic cancer cell proliferation was inhibited by overexpression of miR-185, which was shown to regulate the migration and angiogenesis of HUVECs by targeting ALK4 for suppression. +epigenetics 32365959 hsa-mir-505 Tuberculosis, Pulmonary In conclusions, aberrant DNA methylation over the PARP9/miR505/RASGRP4/GNG12 genes may contribute to the development of active pulmonary TB disease and its clinical phenotypes, while aberrant DNA methylation over the WIPI2/GNG12/MARPS18B/FOXO3 genes may constitute a determinant of long-term outcomes. +other 32365219 hsa-mir-9 Melanoma Bioinformatics analysis demonstrated that SNHG7 functions as a molecular sponge for miR-9 in biological behavior of melanoma cells. +circulation_biomarker_diagnosis_ns 32365051 hsa-mir-25 Diabetes Mellitus 3p were low-expressed in the peripheral venous blood samples of diabetes mellitus (DM) patients compared to normal volunteers, and high-glucose inhibited METTL3 and miR +genetics_overexpression_promote 32364763 hsa-mir-362 Carcinoma, Non-Small-Cell Lung These results demonstrate that E2F1-induced overexpression of SBF2-AS1 promotes the expression of GRB2 by targeting miR3p to facilitate the metastasis of NSCLC. +genetics_overexpression_promote 32364676 hsa-mir-374b Carcinoma, Non-Small-Cell Lung Functionally, overexpression of miR-374b inhibited cell viability and metastasis in NSCLC. +transcription factor target 32364673 hsa-mir-100 Carcinoma, Non-Small-Cell Lung Western blot analysis demonstrated that miR-100 exerted suppressive functions via regulating EMT and Wnt/beta-catenin in NSCLC cells. +lncRNA target 32364663 hsa-mir-1237 Nasopharyngeal Carcinoma Collectively, our results indicate that AATBC promotes NPC progression through the miR3p-PNN-ZEB1 axis. +genetics_GWAS 32364585 hsa-mir-618 Hirschsprung Disease In conclusion, our results indicated that the miR-618 rs2682818 C>A polymorphism was associated with a reduced risk of HSCR in Chinese children, especially in patients with long-segment HSCR (L-HSCR) subtype. +genetics_overexpression_promote 32364530 hsa-mir-183 Colorectal Neoplasms Exosomes overexpressing miR +circulation_biomarker_diagnosis_ns 32364222 hsa-mir-219a Carcinoma, Non-Small-Cell Lung Compared with radiosensitive (RS) NSCLC patients, miR-219a-5p expression was decreased in serum and lung tissue in radioresistant patients. +other 32363318 hsa-mir-34a Non-alcoholic Fatty Liver Disease In multivariate analysis, miR-34a, miR-122, and miR-192 levels are independently associated with hepatic steatosis and fibrosis, but not lobular inflammation or ballooning degeneration, whereas miR-200a is only associated with fibrosis. +other 32363318 hsa-mir-122 Non-alcoholic Fatty Liver Disease We found that miR-34a, miR-122, miR-192, miR-200a, but not miR-191, strongly correlate with fibrosis in NAFLD by increases of 0.20 to 0.40 SD (P < 0.005) with each stage of fibrosis. In multivariate analysis, miR-34a, miR-122, and miR-192 levels are independently associated with hepatic steatosis and fibrosis, but not lobular inflammation or ballooning degeneration, whereas miR-200a is only associated with fibrosis. +other 32363318 hsa-mir-192 Non-alcoholic Fatty Liver Disease We found that miR-34a, miR-122, miR-192, miR-200a, but not miR-191, strongly correlate with fibrosis in NAFLD by increases of 0.20 to 0.40 SD (P < 0.005) with each stage of fibrosis. In multivariate analysis, miR-34a, miR-122, and miR-192 levels are independently associated with hepatic steatosis and fibrosis, but not lobular inflammation or ballooning degeneration, whereas miR-200a is only associated with fibrosis. +circulation_biomarker_diagnosis_ns 32363318 hsa-mir-200a Non-alcoholic Fatty Liver Disease We examined the differential relationships of five of the best-described circulating microRNAs (miR-34a, miR-122, miR-191, miR-192, and miR-200a) with histological features and pathogenic factors of NAFLD. +circulation_biomarker_diagnosis_ns 32363003 hsa-mir-371a Testicular Germ Cell Tumor Graded expression of microRNA-371a-3p in tumor tissues, contralateral testes, and in serum of patients with testicular germ cell tumor. +other 32362622 hsa-mir-449c Carcinoma, Non-Small-Cell Lung RESULTS: Real-time polymerase chain reaction data revealed that the expression of mir-2114 and mir-449c in AC and mir-2115 in SCC was significantly upregulated. +other 32362622 hsa-mir-2114 Carcinoma, Non-Small-Cell Lung RESULTS: Real-time polymerase chain reaction data revealed that the expression of mir-2114 and mir-449c in AC and mir-2115 in SCC was significantly upregulated. +other 32362622 hsa-mir-2115 Carcinoma, Non-Small-Cell Lung RESULTS: Real-time polymerase chain reaction data revealed that the expression of mir-2114 and mir-449c in AC and mir-2115 in SCC was significantly upregulated. +transcription factor target 32361970 hsa-mir-29b Immune System Diseases In this study, several miRNAs in the immuno-related pathways were found to be dysregulated in RAW264.7 cells after 24-h exposure to TiO(2) NPs, including miR-29b-3p, which had not been previously found to be associated with the dysregulation of immunity after exposure to TiO(2) NPs. +lncRNA target 32361708 hsa-mir-515 Arthritis, Rheumatoid 5p inhibitor promoted the phosphorylation of JNK in the RAFLS cells. +transcription factor target 32361707 hsa-mir-10b Lung Neoplasms Inhibition of miR-10b could restrain the development of lung cancer by increasing LATS2 expression via TAZ. +genetics_overexpression_suppress 32361613 hsa-mir-16 Inflammatory Bowel Diseases RESULTS: MiR-16 was overexpressed in the IBD model, whereas Bcl-2 had lower expression in the mucosa. +circulation_biomarker_diagnosis_ns 32360974 hsa-mir-30 Stroke We previously observed a decrease of miR-330 in a miRNA profile of plasma from patients within 3 h after a stroke. +other 32360974 hsa-mir-30 Edema Pretreating animals with miR-330 antagomir could decrease cerebral infarction, edema, mortality, and apoptosis after 6-h pMCAO. +other 32360974 hsa-mir-30 Cerebral Infarction Pretreating animals with miR-330 antagomir could decrease cerebral infarction, edema, mortality, and apoptosis after 6-h pMCAO. +circulation_biomarker_diagnosis_down 32360974 hsa-mir-30 Anodontia MiR-330 levels decreased both in rat plasma and in ipsilateral brain tissues after H/I. +other 32360974 hsa-mir-30 Hypoxia Our study further focused on the role and mechanism of miR-330 in mitophagy induced by hypoxia-ischemia (H/I) in rats. +other 32360865 hsa-mir-1303 Breast Neoplasms Functionally, excessive miR-1303 promoted the malignant phenotypes of breast cancer cells. +other 32360840 hsa-mir-199b Breast Neoplasms The expression of miR-199b-5p was downregulated in the malignant tumors and was negatively associated with TNBC, stage and Her2+. +other 32360840 hsa-mir-199a Breast Neoplasms AIMS: The purpose of present study was to examine the correlations of LDL (LDLR) and HDL (SR-B1) receptors with lipoproteins, miR-199a-5p, miR-199b-5p, miR5p in the malignant and benign breast tumors. +other 32360840 hsa-mir-455 Breast Neoplasms AIMS: The purpose of present study was to examine the correlations of LDL (LDLR) and HDL (SR-B1) receptors with lipoproteins, miR-199a-5p, miR-199b-5p, miR5p in the malignant and benign breast tumors. +circulation_biomarker_diagnosis_down 32360711 hsa-mir-24 Metabolic Diseases CONCLUSIONS: Blood levels of miR +circulation_biomarker_diagnosis_down 32360711 hsa-mir-24 Diabetes Mellitus, Type 2 CONCLUSIONS: Blood levels of miR +circulation_biomarker_diagnosis_down 32360711 hsa-let-7f Metabolic Diseases CONCLUSIONS: Blood levels of miR +circulation_biomarker_diagnosis_down 32360711 hsa-let-7f Diabetes Mellitus, Type 2 CONCLUSIONS: Blood levels of miR +circulation_biomarker_diagnosis_down 32360711 hsa-mir-214 Diabetes Mellitus, Type 2 CONCLUSIONS: Blood levels of miR +circulation_biomarker_diagnosis_down 32360711 hsa-mir-214 Metabolic Diseases CONCLUSIONS: Blood levels of miR +lncRNA target 32360624 hsa-mir-150 Diabetes Mellitus, Type 1 miR-150 suppressed PUMA to inhibit the T1D-induced inflammation and beta cell apoptosis whereas NF-kappaB activated the miR-150 expression by binding to the miR-150 promoter, thereby preventing the T1D-induced inflammation and beta cell apoptosis. +genetics_overexpression_promote 32359894 hsa-mir-224 Stomach Neoplasms Overexpression of LINC00619 or OPCML or downregulation of miR +genetics_overexpression_promote 32359391 hsa-mir-92a Stomach Neoplasms Overexpression of miRNA-92a promotes the proliferation, migration and invasiveness of GC cells, and plays a role similar to that of oncogene. +circulation_biomarker_diagnosis_up 32359364 hsa-mir-486 Carcinoma, Ovarian Epithelial 5p level in serum and ascites samples was significantly correlated with the severity of the endometriosis. +circulation_biomarker_diagnosis_up 32359364 hsa-mir-486 Endometriosis 5p level in serum and ascites samples was significantly correlated with the severity of the endometriosis. +lncRNA target 32358022 hsa-mir-21 limb ischemia CD34(+) cells from T2D-CLI patients were more apoptotic and less proangiogenic than those from control subjects and featured miRNA-21 downregulation, modulation of several long noncoding RNAs acting as miRNA-21 sponges, and upregulation of the miRNA-21 proapoptotic target PDCD4. +other 32358019 hsa-mir-21 Immune System Diseases Taken together, our findings indicate that the Stat3/Cebpbeta-miR-21a/b/181b-Mll1-complex axis may play a critical role in PMN-MDSC expansion, activation, and differentiation, and this axis may provide an effectively immunological therapeutic approach for patients with cancer or other immunological diseases. +other 32358019 hsa-mir-181b Immune System Diseases Taken together, our findings indicate that the Stat3/Cebpbeta-miR-21a/b/181b-Mll1-complex axis may play a critical role in PMN-MDSC expansion, activation, and differentiation, and this axis may provide an effectively immunological therapeutic approach for patients with cancer or other immunological diseases. +genetics_overexpression_promote 32357945 hsa-mir-363 Osteosarcoma In addition, low expression of miR-363 or overexpression of NOB1 predicted poor prognosis of osteosarcoma patients. +genetics_knock down_promote 32357909 hsa-mir-21 Temporomandibular Joint Dysfunction Syndrome 5p knockout on TMJOA was evaluated by toluidine blue (TB), immunohistochemical (IHC) staining, Western blotting (WB) and RT-qPCR. +transcription factor target 32357822 hsa-mir-520c Carcinoma, Hepatocellular CONCLUSION: Our data referred to the tumor suppressor function of miR-520c-3p that could modulate the chemosensitivity of HepG2 cells towards DOX treatment, providing a promising therapeutic strategy in HCC. +lncRNA target 32357442 hsa-mir-34a Breast Neoplasms In conclusion, the clinical relevance of miR-34a high expressing tumors was associated with suppressed cell proliferation, enhanced p53 pathway and apoptosis, but enhanced EMT and these findings did not reflect better survival outcomes in large BC patient cohorts. +genetics_overexpression_promote 32357145 hsa-mir-27b Stomach Neoplasms HCP5 was overexpressed in GC cells, but this was reversed by miR-27b-3p. +circRNA target 32357143 hsa-mir-767 Carcinoma, Non-Small-Cell Lung Knocking down hsa_circ_0018818 using a targeted shRNA inhibited the proliferation and invasiveness of NSCLC cells and induced their apoptosis via the miR3p/Nidogen 1 (NID1) signaling axis. +lncRNA target 32356485 hsa-mir-139 Esophageal Squamous Cell Carcinoma 3p acted as a tumor suppressor by targeting membrane metalloendopeptidase in esophageal carcinoma, and low expression of membrane metalloendopeptidase may indicate a better prognosis of patients with esophageal carcinoma. +circulation_biomarker_diagnosis_up 32356483 hsa-mir-124 Uterine Cervical Neoplasms The detection of serum microRNA-21, microRNA-124, and macrophage colony-stimulating factor has good sensitivity and specificity in the diagnosis of cervical cancer. +other 32356483 hsa-mir-21 Uterine Cervical Neoplasms The expression of microRNA-21, microRNA-124, and macrophage colony-stimulating factor in the patients correlated with the tumor size, tumor node metastasis (TNM) staging, tumor differentiation, and the presence or absence of lymph node metastasis and human papillomavirus infection (P < .05). +other 32356454 hsa-mir-17 Acute Coronary Syndrome 5p) were lower with colchicine treatment. +lncRNA target 32356447 hsa-mir-485 Colorectal Neoplasms 3p as a suppressor for colorectal cancer (Tab. +lncRNA target 32356314 hsa-mir-129 Stomach Neoplasms 5p transfection suppressed gastric cancer cell proliferation through inducing G1 phase arrest in vitro and inhibit xenograft tumor growth in vivo. +lncRNA target 32355808 hsa-mir-15b Leprosy The candidate miRNAs were further validated in a larger sample of 17 LPR and 22 HPR patients by quantitative reverse-transcription polymerase chain reaction (RT-qPCR), and miR-15b was found differentially expressed. Furthermore, the expression of miR-15b, a miRNA known to induce cell apoptosis via targeting of Bcl-2, was confirmed by RT-qPCR (P=0.020) to be 1.4x higher in the platelets of LPR patients than in those of HPR patients. +lncRNA target 32355808 hsa-mir-15b Hereditary pancreatitis The candidate miRNAs were further validated in a larger sample of 17 LPR and 22 HPR patients by quantitative reverse-transcription polymerase chain reaction (RT-qPCR), and miR-15b was found differentially expressed. Furthermore, the expression of miR-15b, a miRNA known to induce cell apoptosis via targeting of Bcl-2, was confirmed by RT-qPCR (P=0.020) to be 1.4x higher in the platelets of LPR patients than in those of HPR patients. +other 32355738 hsa-mir-581 Carcinoma, Hepatocellular Conclusions We identified three hub genes, and our results suggest that the circHMGCS1/miR-581/AURKA, circHMGCS1/miR-892a/KIF5B, and circTMCO3/miR-577/RHOA axes may play a vital role in HCC progression. +other 32355738 hsa-mir-892a Carcinoma, Hepatocellular Conclusions We identified three hub genes, and our results suggest that the circHMGCS1/miR-581/AURKA, circHMGCS1/miR-892a/KIF5B, and circTMCO3/miR-577/RHOA axes may play a vital role in HCC progression. +other 32355738 hsa-mir-577 Carcinoma, Hepatocellular Conclusions We identified three hub genes, and our results suggest that the circHMGCS1/miR-581/AURKA, circHMGCS1/miR-892a/KIF5B, and circTMCO3/miR-577/RHOA axes may play a vital role in HCC progression. +target gene 32355723 hsa-mir-485 Pancreatic Neoplasms emcitabine resistance can alter the fraction of memory CD4+ T cells via hsa-miR-3178, hsa-miR-485-3p, hsa-miR-574-5p and hsa-miR-584-5p targeted MSI2, TEAD1, GNPDA1, RND3, PRKACB, TRIM68, and YKT6 network in PC. +target gene 32355723 hsa-mir-584 Pancreatic Neoplasms emcitabine resistance can alter the fraction of memory CD4+ T cells via hsa-miR-3178, hsa-miR-485-3p, hsa-miR-574-5p and hsa-miR-584-5p targeted MSI2, TEAD1, GNPDA1, RND3, PRKACB, TRIM68, and YKT6 network in PC. +target gene 32355723 hsa-mir-574 Pancreatic Neoplasms emcitabine resistance can alter the fraction of memory CD4+ T cells via hsa-miR-3178, hsa-miR-485-3p, hsa-miR-574-5p and hsa-miR-584-5p targeted MSI2, TEAD1, GNPDA1, RND3, PRKACB, TRIM68, and YKT6 network in PC. +target gene 32355723 hsa-mir-3178 Pancreatic Neoplasms emcitabine resistance can alter the fraction of memory CD4+ T cells via hsa-miR-3178, hsa-miR-485-3p, hsa-miR-574-5p and hsa-miR-584-5p targeted MSI2, TEAD1, GNPDA1, RND3, PRKACB, TRIM68, and YKT6 network in PC. +exosome 32355577 hsa-mir-1 Liver Injury CONCLUSION: We explored the potential functions of DE-miRNAs and suggested exosomal miR3p might be the essential exosomal miRNA in the pathogenesis of AILI. +exosome 32355577 hsa-mir-1 Breast Neoplasms CONCLUSION: We explored the potential functions of DE-miRNAs and suggested exosomal miR3p might be the essential exosomal miRNA in the pathogenesis of AILI. +target gene 32355540 hsa-mir-520b Liver Neoplasms MicroRNA-520b targets interlukin-2 to regulate the growth, metastasis and drug sensitivity of liver cancer cells. +other 32355522 hsa-mir-21 Nasopharyngeal Carcinoma BACKGROUND: We assess the effects exerted by CRISPR/Cas9 mediated microRNA 21 (miR-21) depletion on the biologic characteristics of CNE2 nasopharyngeal carcinoma (NPC) cells and the underlying mechanisms. +circulation_biomarker_diagnosis_ns 32355521 hsa-mir-616 Coronary Artery Disease Results showed that in the serum of patients with coronary atherosclerosis, there was lower PON1 activity and PON1 level, the same trend in Linc-OIP5, and the opposite trend in miR-616 expression. Thus Linc-OIP5 working as a ceRNA of miR-616 apparently promotes PON1 expression in HUEVC cells and Linc-OIP5 and miR-616 may be an ideal target for the treatment of coronary atherosclerosis in the future. +other 32355519 hsa-mir-519 Lung Neoplasms Downregulation of microRNA-519 enhances development of lung cancer by mediating the E2F2/PI3K/AKT axis. +other 32355517 hsa-mir-21 Lung Neoplasms miR-21 promotes growth, invasion and migration of lung cancer cells by AKT/P-AKT/cleaved-caspase 3/MMP-2/MMP-9 signaling pathway. +other 32355516 hsa-mir-566 Intracranial Aneurysm RESULTS: The miR-566 level was significantly higher in intracranial aneurysm tissues than that in normal arterial wall tissues (P<0.05). CONCLUSION: The abnormal expression of miR-566 affects the immune function, thus promoting the occurrence and deterioration of intracranial aneurysm. +target gene 32355466 hsa-mir-144 Breast Neoplasms A long non-coding RNA LINC00461-dependent mechanism underlying breast cancer invasion and migration via the miR-144-3p/KPNA2 axis. +genetics_overexpression_promote 32355035 hsa-mir-1298 Glioma Importantly, overexpression of miR +other 32354626 hsa-mir-155 Carcinoma, Pancreatic Ductal 5p/NDFIP1 promotes tumor progression and EMT of PDAC. +lncRNA target 32354230 hsa-mir-205 Gynecological Cancer In conclusion, our findings suggest miR-205 may be a promising prognostic biomarker and therapeutic target for BC and EC patients. +other 32354168 hsa-mir-505 Cerebral Infarction Importantly, these common miRNAs were inversely regulated in each comparison (e.g., C < P > T), including miR5p, which was previously reported to be upregulated in aortic stenosis patients. +lncRNA target 32353736 hsa-mir-548e Ovarian Neoplasms In conclusion, ZFAS1 binds with miR-548e to enhance CXCR4 expression to promote OC cell proliferation and metastasis, which also enhances cisplatin resistance by suppressing let-7a and elevating BCL-XL/S protein expression. +circulation_biomarker_diagnosis_ns 32353552 hsa-mir-24 Metabolic Diseases The current study aims to evaluate whether peripheral blood miR +lncRNA target 32353411 hsa-mir-34c Endometriosis This study investigated the role of a specific miRNA, miR-34c-5p, in endometriosis. High-throughput sequencing (HTS) showed that miR-34c-5p expression was reduced in ectopic endometrium (ecEM) in patients from Northeast Asia with ovarian endometriosis. +other 32353171 hsa-mir-340 Diabetic Nephropathies In addition, we observed a strong association between MALAT1, LNC-EPHA6, and LIPCAR and vascular injury marker soluble thrombomodulin and a subset of angiogenic microRNAs (miR-27a, miR-130b, miR-152, and miR-340). +other 32353171 hsa-mir-130b Diabetic Nephropathies In addition, we observed a strong association between MALAT1, LNC-EPHA6, and LIPCAR and vascular injury marker soluble thrombomodulin and a subset of angiogenic microRNAs (miR-27a, miR-130b, miR-152, and miR-340). +other 32353171 hsa-mir-27a Diabetic Nephropathies In addition, we observed a strong association between MALAT1, LNC-EPHA6, and LIPCAR and vascular injury marker soluble thrombomodulin and a subset of angiogenic microRNAs (miR-27a, miR-130b, miR-152, and miR-340). +other 32353171 hsa-mir-152 Diabetic Nephropathies In addition, we observed a strong association between MALAT1, LNC-EPHA6, and LIPCAR and vascular injury marker soluble thrombomodulin and a subset of angiogenic microRNAs (miR-27a, miR-130b, miR-152, and miR-340). +genetics_knock down_promote 32352854 hsa-mir-214 Colonic Neoplasms 3p can bind to DNAJC3-AS1, and knockdown of DNAJC3-AS1 increased miR +circulation_biomarker_diagnosis_ns 32352717 hsa-mir-20a Inflammatory Bowel Diseases DISCUSSION: MiR-320a expression in peripheral blood from patients with IBD follows the clinical and endoscopic disease activities and may help to distinguish IBD from infectious colitis. +other 32352616 hsa-let-7b Ischemic Stroke CONCLUSIONS: Combined analyses of Fas and has-let-7b-5p expression in addition to traditional risk factors are favorable prognostic biomarkers for predicting poor neurological outcomes at 3 months after stroke onset in ischaemic stroke patients. +other 32352616 hsa-let-7b Retinitis CONCLUSIONS: Combined analyses of Fas and has-let-7b-5p expression in addition to traditional risk factors are favorable prognostic biomarkers for predicting poor neurological outcomes at 3 months after stroke onset in ischaemic stroke patients. +circulation_biomarker_diagnosis_ns 32352018 hsa-mir-21 Ovarian Insufficiency, Premature For autoimmune POI patients, serum miR-21, PBMCs Peli1 mRNA levels, general data, immune parameters, hormone levels, and ultrasound examinations were obtained. +other 32351983 hsa-mir-429 Glioma Our findings suggest the PART1-hsa-miRSHCBP1 regulatory network plays an important role in gliomas. +circulation_biomarker_diagnosis_up 32351734 hsa-mir-21 Angina, Unstable This research finding suggested that plasma microRNA-21 may be considered as a suitable new biomarker for early detection of stable and unstable angina patients, and it has a strong correlation with aging. +target gene 32351538 hsa-mir-144 Prostatic Neoplasms Long Non-coding RNA SNHG17 Promotes Cell Proliferation and Invasion in Castration-Resistant Prostate Cancer by Targeting the miR-144/CD51 Axis. +other 32351331 hsa-mir-494 Cerebral Hemorrhage miR-494 may provide a promising therapeutic clue for ICH. +lncRNA target 32351330 hsa-mir-491 Stomach Neoplasms CONCLUSION: In a word, LBX2-AS1 up-regulated by NFIC promoted GC progression via targeting miR +genetics_overexpression_promote 32351328 hsa-mir-135 Hemoglobinuria, Paroxysmal The overexpression of miR-135b promoted proliferation, migration, and invasion of PCSC, inhibited cell apoptosis and increased the expression of stemness-related factors (Sox-2, Oct-4, Nanog, Aldh1, and Slug). +genetics_overexpression_promote 32351328 hsa-mir-135b Hemoglobinuria, Paroxysmal The overexpression of miR-135b promoted proliferation, migration, and invasion of PCSC, inhibited cell apoptosis and increased the expression of stemness-related factors (Sox-2, Oct-4, Nanog, Aldh1, and Slug). +other 32351328 hsa-mir-135b Pancreatic Carcinoma The study aimed to investigate the functional role of miR-135b and its associated mechanism to unravel the biological characteristics of tumor growth in pancreatic cancer stem cells (PCSCs). +other 32351328 hsa-mir-135 Pancreatic Carcinoma The study aimed to investigate the functional role of miR-135b and its associated mechanism to unravel the biological characteristics of tumor growth in pancreatic cancer stem cells (PCSCs). +genetics_overexpression_suppress 32351327 hsa-mir-654 Osteosarcoma 3p inhibition or SYTL2 overexpression could counteract the inhibitory effect caused by BSN-AS2 deficiency on spinal OS progression. +lncRNA target 32351291 hsa-mir-432 Pancreatic Carcinoma 5p which normally directly targeted PPME1 to downregulate its expression. +genetics_overexpression_suppress 32351126 hsa-mir-195 Pulmonary Disease, Chronic Obstructive Moreover, overexpression of miR +lncRNA target 32351100 hsa-mir-1294 Adenocarcinoma of Lung LINC00473 can bind to miR-1294, and reciprocal inhibition between LINC00473 and miR-1294 expression was identified in lung adenocarcinoma. +target gene 32351034 hsa-mir-223 Dermatitis, Atopic Observational studies revealed dysregulation of miRNAs, including miR-143, miR-146a, miR-151a, miR-155 and miR-223, in AD patients. +target gene 32351034 hsa-mir-143 Dermatitis, Atopic Observational studies revealed dysregulation of miRNAs, including miR-143, miR-146a, miR-151a, miR-155 and miR-223, in AD patients. +target gene 32351034 hsa-mir-146a Dermatitis, Atopic Observational studies revealed dysregulation of miRNAs, including miR-143, miR-146a, miR-151a, miR-155 and miR-223, in AD patients. +target gene 32351034 hsa-mir-155 Dermatitis, Atopic Observational studies revealed dysregulation of miRNAs, including miR-143, miR-146a, miR-151a, miR-155 and miR-223, in AD patients. +target gene 32351034 hsa-mir-151a Dermatitis, Atopic Observational studies revealed dysregulation of miRNAs, including miR-143, miR-146a, miR-151a, miR-155 and miR-223, in AD patients. +genetics_GWAS 32350671 hsa-mir-133b Myotonic Disorders Myotonic dystrophy type 1(DM1) patients have a disease-specific serum miRNA profile characterized by upregulation of miR-1, miR-206, miR-133a, and miR-133b (myomiRNAs).This study aims to evaluate the possible utility of myomiRs and myostatin as biomarkers of rehabilitation efficacy in DM1, supporting clinical outcomes that are often variable and related to the patient's clinical condition.In 9 genetically proven DM1 patients, we collected biological samples before (T0) and after (T1) exercise rehabilitation training as biological measurement. +genetics_GWAS 32350671 hsa-mir-1 Myotonic Disorders Myotonic dystrophy type 1(DM1) patients have a disease-specific serum miRNA profile characterized by upregulation of miR-1, miR-206, miR-133a, and miR-133b (myomiRNAs).This study aims to evaluate the possible utility of myomiRs and myostatin as biomarkers of rehabilitation efficacy in DM1, supporting clinical outcomes that are often variable and related to the patient's clinical condition.In 9 genetically proven DM1 patients, we collected biological samples before (T0) and after (T1) exercise rehabilitation training as biological measurement. +genetics_GWAS 32350671 hsa-mir-206 Myotonic Disorders Myotonic dystrophy type 1(DM1) patients have a disease-specific serum miRNA profile characterized by upregulation of miR-1, miR-206, miR-133a, and miR-133b (myomiRNAs).This study aims to evaluate the possible utility of myomiRs and myostatin as biomarkers of rehabilitation efficacy in DM1, supporting clinical outcomes that are often variable and related to the patient's clinical condition.In 9 genetically proven DM1 patients, we collected biological samples before (T0) and after (T1) exercise rehabilitation training as biological measurement. +lncRNA target 32350569 hsa-mir-455 Coronary Artery Disease 3p alleviates IHF by targeting TRAF6. +genetics_overexpression_promote 32350561 hsa-mir-222 Cicatrix, Hypertrophic The overexpression of miR-222 enhanced the HS fibroblast proliferation, increased the cell population in the S phase, inhibited the cell apoptosis, enhanced the expression levels of Col1A1, Col3A1 mRNA/protein, proliferating cell nuclear antigen (PCNA), cyclin D1, cyclin E1 and CDK1 and reduced the expression levels of cleaved caspase-3/9. +other 32350368 hsa-mir-29a Lipedema 5p) was significantly downregulated in lipedema. +other 32350368 hsa-mir-24 Lipedema 5p) was significantly downregulated in lipedema. +other 32350368 hsa-mir-16 Lipedema 5p) was significantly downregulated in lipedema. +other 32350368 hsa-mir-130a Lipedema 5p) was significantly downregulated in lipedema. +other 32350368 hsa-let-7c Lipedema 5p) was significantly downregulated in lipedema. +genetics_overexpression_promote 32350057 hsa-mir-4454 Ovarian Neoplasms Stable overexpression of miR-4454 decreased metastasis in ovarian cancer xenografts. +other 32349937 hsa-mir-654 Atherosclerosis CONCLUSION: In conclusion, ZFAS1 elevated ADAM10/RAB22A expression to reduce cholesterol efflux rate and facilitate inflammatory responses in atherosclerosis at a miR3p-dependent way, suggesting a prospective treatment method for amelioration of atherosclerosis. +other 32349783 hsa-mir-138 Ovarian Neoplasms 5p to prevent its binding to EZH2 and SIRT1, thereby promoting DDP-resistance of ovarian cancer cells. +lncRNA target 32349744 hsa-mir-34a Carcinoma, Non-Small-Cell Lung In NSCLC cells, over-expression of FEZF1-AS1 resulted in up-regulated expressions of NOTCH-1, while miR-34a over-expression mediated down-regulated expressions of NOTCH-1. CONCLUSIONS: FEZF1-AS1 promoted NSCLC cell migration and invasion through the up-regulation of NOTCH1 by serving as a sponge of miR-34a. +other 32349546 hsa-mir-194 Colorectal Neoplasms In addition, quantitative real-time-polymerase chain reaction was used to detect the expression levels of the lncRNA MALAT1 and the hsa-miR5p in cancer tissues and paracancerous normal tissues of CRC patients. +other 32349536 hsa-mir-6507 Uterine Cervical Neoplasms 5p) and some transcription factors were found to be associated with prognosis of CC. +other 32349536 hsa-mir-101 Uterine Cervical Neoplasms 5p) and some transcription factors were found to be associated with prognosis of CC. +genetics_overexpression_promote 32349525 hsa-mir-378a Urinary Bladder Neoplasms Overexpressed miR-378a-3p restrained the activity, migration, and invasion of bladder cancer cells, which was the same as the effects of silent LINC00958 and downregulated IGF1R. +lncRNA target 32349217 hsa-mir-155 Glioblastoma 5p-RNF123-NF-kappaB1-p50-SerpinE1) that may represent a new therapeutic target pathway for GB patients with isocitrate dehydrogenase 1 and 2 (IDH) WT (wild type). +transcription factor target 32348962 hsa-mir-23b Obesity Our results suggest that miRNAs are involved in cold-mediated BAT thermogenic activation and further acknowledged miR-23b-5p as a negative regulator in controlling thermogenic programs, further providing potential molecular therapeutic targets to increase surplus energy and treat obesity. +other 32348937 hsa-mir-1468 Anemia, Sickle Cell Old SCD victims with PMF and healthy aged human hearts showed increased expression of miR3p. +other 32348937 hsa-mir-1468 Mycosis Fungoides Old SCD victims with PMF and healthy aged human hearts showed increased expression of miR3p. +transcription factor target 32348937 hsa-mir-1468 Cardiomyopathies Targeting miR +genetics_overexpression_promote 32348630 hsa-mir-505 Osteosarcoma Overexpression of miR-505 and silencing of HMGB1 suppressed the proliferation, migration, and invasion of osteosarcoma cells and increased the rate of apoptosis, whereas the co-transfected miR-505 mimics si-HMGB1 demonstrated a more significant inhibitory effect on the proliferation and invasion of osteosarcoma cells and a higher apoptosis rate. +genetics_knock down_promote 32348429 hsa-mir-378a Cataract The rescue experiments further revealed that E2F3 knockdown could recover miR-378a-5p, and miR-630 inhibitor induced promotion of cell proliferation and inhibition of apoptosis in cataract. +genetics_knock down_promote 32348429 hsa-mir-630 Cataract The rescue experiments further revealed that E2F3 knockdown could recover miR-378a-5p, and miR-630 inhibitor induced promotion of cell proliferation and inhibition of apoptosis in cataract. +other 32348425 hsa-mir-22 Depression In this study, we aimed to explore the relationship among miR-22, deep cerebral microbleeds (CMBs), and post-stroke depression (PSD) 1 month after ischemic stroke. These findings indicate that miR-22 might be involved in cerebral microvascular impairment and post-stroke depression. +other 32348425 hsa-mir-22 Ischemic Stroke In this study, we aimed to explore the relationship among miR-22, deep cerebral microbleeds (CMBs), and post-stroke depression (PSD) 1 month after ischemic stroke. These findings indicate that miR-22 might be involved in cerebral microvascular impairment and post-stroke depression. +other 32348425 hsa-mir-22 Depression, Post Stroke In this study, we aimed to explore the relationship among miR-22, deep cerebral microbleeds (CMBs), and post-stroke depression (PSD) 1 month after ischemic stroke. These findings indicate that miR-22 might be involved in cerebral microvascular impairment and post-stroke depression. +genetics_GWAS 32348112 hsa-mir-137 Multiple Sclerosis We propose rs2067079 and rs1625579 as novel genetic markers of MS susceptibility, and at least, rs2067079 possibly impacts the crosstalk between GAS5 and miR-137. +genetics_overexpression_promote 32347652 hsa-mir-646 Carcinoma, Non-Small-Cell Lung Functional assays showed that overexpression of miR-646 could suppress NSCLC cell proliferation, clonogenicity, invasion, and inhibit epithelial-mesenchymal transition (EMT), whereas decreased miR-646 expression showed the opposite effects. +genetics_knock down_suppress 32347551 hsa-mir-142 Acute Kidney Injury Subsequently, loss of PDCD4 was able to retard injury in HK-2 cells exposed to CoCl(2.) Thus, we suggest that XIST regulates miR +other 32347320 hsa-mir-26b Aortic Diseases In ex vivo models, GAS5 was significantly downregulated and its expression inversely related to the expression of miR-26b-5 and positively associated with the expression of PTEN in calcified aortic rings induced by high levels of phosphorus. +lncRNA target 32347320 hsa-mir-26 Ventricular Premature Complexes Together, these results suggest that the GAS5/miR5p/PTEN axis could serve as a potential therapeutic target for VC in patients with chronic kidney disease. +lncRNA target 32347320 hsa-mir-26 Kidney Failure, Chronic Together, these results suggest that the GAS5/miR5p/PTEN axis could serve as a potential therapeutic target for VC in patients with chronic kidney disease. +lncRNA target 32347320 hsa-mir-26 Kidney Diseases Together, these results suggest that the GAS5/miR5p/PTEN axis could serve as a potential therapeutic target for VC in patients with chronic kidney disease. +transcription factor target 32347292 hsa-mir-760 Carcinoma, Non-Small-Cell Lung ROS1 might be a target gene of miR-760 in NSCLC. +transcription factor target 32347076 hsa-mir-20a Carcinoma, Non-Small-Cell Lung RUNX3 was verified as the direct target of miR-20a and it could overturn its biological function in NSCLC cells. +exosome 32347050 hsa-mir-124 Neuroblastoma A specific type of miRNAs, i.e., miR-124 was successfully delivered to M17 NB cells with the aid of hAD-MSCs using the direct or indirect (exosome-based) contacts. +transcription factor target 32346884 hsa-mir-181a Benign Paroxysmal Positional Vertigo The antiangiogenic effect of miR-181a-5p on RNV was verified by intravitreal injection, and we showed that this involved the extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) signaling pathway. Collectively, our data demonstrate that miR-181a-5p/endocan regulates retinal angiogenesis through the ERK1/2 signaling pathway and might represent an attractive therapeutic strategy for RNV. +lncRNA target 32346696 hsa-mir-212 Squamous Cell Carcinoma of Head and Neck 3p inhibitor could reverse the effects of TUG1 siRNA on proliferation, apoptosis and NK cell killing rate of oral squamous cell carcinoma cells. +other 32346618 hsa-mir-146a Diabetes Mellitus Therefore, miR-146a could be suggested as a potential therapeutic molecule and as a common inflammatory regulator for both obesity-induced diabetes and related periodontal diseases. +transcription factor target 32346618 hsa-mir-146a Periodontal Diseases Therefore, in this study, the inhibitory effects of miR-146a on both adipose and periodontal inflammation, was investigated. Therefore, miR-146a could be suggested as a potential therapeutic molecule and as a common inflammatory regulator for both obesity-induced diabetes and related periodontal diseases. +other 32346449 hsa-mir-372 Pancreatitis, Acute Hemorrhagic In summary, the expression of miR-372 in HTGAP was significantly upregulated and increased with the severity of the disease. +other 32346440 hsa-mir-7 Aortic Aneurysm, Abdominal The expression levels of miR-7 were upregulated, whereas the levels of CDR1as and cytoskeleton-associated protein 4 (CKAP4) were downregulated in aortic specimens obtained from 10 patients who underwent surgery for AAA compared with aortic specimens from 10 control patients who underwent coronary artery bypass surgery. +target gene 32346439 hsa-mir-147 Urinary Bladder Neoplasms circ_0067934 increases bladder cancer cell proliferation, migration and invasion through suppressing miR-1304 expression and increasing Myc expression levels. +target gene 32346435 hsa-mir-196a Squamous Cell Carcinoma of Head and Neck Investigating the role and mechanism of microRNA-196a in oral squamous cell carcinoma by targeting FOXO1. +target gene 32346424 hsa-mir-454 stomach carcinoma miR-454 promotes survival and induces oxaliplatin resistance in gastric carcinoma cells by targeting CYLD. +lncRNA target 32346421 hsa-mir-663b Myocardial Infarction In conclusion, miR-663b inhibition protected cardiomyocytes against hypoxia-induced injury by targeting BCL2L1 and may potentially be a novel target for the treatment of patients with myocardial infarction. +circulation_biomarker_diagnosis_up 32346417 hsa-mir-135b Ischemic Stroke In conclusion, data from the present study suggest that elevated expression of miR-135b in the peripheral blood of patients with acute ischemic stroke is closely associated with disease severity. +target gene 32346414 hsa-mir-146b Neuroblastoma microRNA-146b promotes neuroblastoma cell growth through targeting NUMB. +other 32346408 hsa-mir-155 Heart Failure Clinical validation revealed that the expression levels of miR-155 were significantly decreased in the HF samples, whereas the expression levels of ETS2 and GPR18 were significantly increased in HF samples. +target gene 32346311 hsa-mir-584 Osteosarcoma MicroRNA-584 Impairs Cellular Proliferation and Sensitizes Osteosarcoma Cells to Cisplatin and Taxanes by Targeting CCN2. +other 32346302 hsa-mir-141 Obesity CONCLUSION: This study identifies that miR-141 and miR-144 are candidate miRNAs associated with the development of HFD-induced cardiac dysfunction and structure alteration. +other 32346302 hsa-mir-144 Obesity CONCLUSION: This study identifies that miR-141 and miR-144 are candidate miRNAs associated with the development of HFD-induced cardiac dysfunction and structure alteration. +lncRNA target 32346298 hsa-mir-486 Carcinoma, Non-Small-Cell Lung 5p was identified as a potential target for LINC01194, and miR +other 32346295 hsa-mir-1207 Osteosarcoma LncRNA OR3A4 Regulated the Growth of Osteosarcoma Cells by Modulating the miR-1207-5p/G6PD Signaling. +exosome 32345959 hsa-mir-16 Breast Neoplasms Our results showed that the BC-derived exosomal SNHG16/miR5p/SMAD5-regulatory axis potentiates TGF-beta1/SMAD5 pathway activation, thus inducing CD73 expression in Vdelta1 T cells. +lncRNA target 32345785 hsa-let-7a Tuberculosis In conclusion, our data indicated that let-7a-5p upregulation repressed TGF-beta2-induced proliferation, migration, invasion and EMT at least partly by targeting Smad2 in LECs, highlighting that let-7a-5p might act as a promising therapeutic target to intervene to the progression of PCO. +genetics_overexpression_promote 32345777 hsa-mir-139 Carcinoma, Non-Small-Cell Lung 5p restoration reversed MIAT-overexpression-induced promotion on the migration and invasion of NSCLC cells. +genetics_overexpression_promote 32345774 hsa-mir-140 Carcinoma, Non-Small-Cell Lung Moreover, overexpression of miR +genetics_knock down_promote 32345773 hsa-mir-4417 Keloid The effect of CyclinD1 knockdown on keloid fibroblasts was similar to that of miR-4417 overexpression. +other 32345666 hsa-mir-487a Rectal Neoplasms CONCLUSION: By combination of miRNA expression profiling and integrative computational biology we identified miR-487a-3p as a potential predictive biomarker of CRT response in LARC patients. +genetics_overexpression_promote 32345599 hsa-mir-106a Uterine Cervical Neoplasms Overexpression of LKB1 neutralized the effect of miR-106a on proliferation and autophagy in cervical cancer cell lines. +other 32345535 hsa-mir-155 Fibrosis Moreover, miR5p upregulation reduced vascular thickening, fibrosis and calcium content of aorta abdominalis in CaCl(2)-mediated VC model. +genetics_overexpression_promote 32345535 hsa-mir-155 Ventricular Premature Complexes 5p overexpression may inhibit VC development through suppressing TGF-beta1/Smad2/3 signaling pathway in vivo and in vitro, indicating that miR +genetics_overexpression_promote 32345470 hsa-mir-145 Uterine Cervical Neoplasms Finally, from the functional experiments results we can see that miR-145 can inhibit the proliferation, migration and invasion of cervical cancer cells, but overexpression of RCAN3 can reverse miR +other 32345320 hsa-mir-34a Spinal Cord Injuries STAT6 bound the promoter of miR-34a to activate its transcription, thus forming two different regulatory loops to modulate the phenotype of macrophages after SCI. +lncRNA target 32345067 hsa-mir-200a Hypertension, Pregnancy-Induced CONCLUSION: MiR-200a was upregulated in PIH patients, andinhibition of miR-200a may improve disease progression, as it could facilitatetrophoblastproliferation, migration and invasionandinhibitapoptosisby targeting ZEB1. +transcription factor target 32345003 hsa-mir-210 Fibrosis, Atrial miR-210 suppresses regulatory T cell function and promotes atrial fibrosis by targeting Foxp3. +other 32344918 hsa-mir-154 Cardiomyopathy, Hypertrophic A total of 2538 protein-coding genes, six microRNAs (miRNAs), and 1617 long noncoding RNAs (lncRNAs) were identified differentially expressed between the groups, including several well-characterized cardiomyopathy-related genes (ANKRD1, FHL2, TGFB3, miR-30d, and miR-154). +genetics_overexpression_suppress 32344629 hsa-mir-26a Seminoma Thus, the aim of this study is to test whether HMGA1 overexpression in human seminomas may be induced by the deregulation of miR-26a and Let-7a-two HMGA1-targeting microRNAs. +genetics_overexpression_suppress 32344629 hsa-let-7a Seminoma Thus, the aim of this study is to test whether HMGA1 overexpression in human seminomas may be induced by the deregulation of miR-26a and Let-7a-two HMGA1-targeting microRNAs. +other 32344560 hsa-mir-132 Parkinson Disease Moreover, the results also indicate that the mmu_circRNA_0003292-miRNANr4a2 pathway might be involved in the regulation of the molecular mechanism of Parkinson's disease. +lncRNA target 32344498 hsa-mir-203a Urinary Bladder Neoplasms Up-regulation of FLJ37505 significantly inhibits the proliferation and migration of bladder cell carcinoma UM-UC-3 cells, and the mechanism might be up-regulating the expression of the INPP4B gene by adsorbing miR-203a-3p. +exosome 32344463 hsa-mir-613 Breast Neoplasms In a conclusion, the study demonstrated that activated fibroblasts exosomes with high levels of miR +exosome 32344463 hsa-mir-613 Endometrial Neoplasms In a conclusion, the study demonstrated that activated fibroblasts exosomes with high levels of miR +transcription factor target 32344160 hsa-mir-149 Lung Neoplasms CONCLUSION: Our study illustrated that Jin formula suppressed the development of lung cancer and the mechanism may be associated with the miR3p/MAZ/Wnt/beta-catenin axis. +transcription factor target 32343998 hsa-mir-455 Cartilage Diseases 3p can reduce the apoptosis of chondrocytes and alleviate OA through regulating PI3K/AKT pathway, which may be expected to be a target for the treatment of osteoarthritis. +other 32343942 hsa-mir-145 Salpingitis In conclusion, abnormally expressed miR-145 may be involved in hydrosalpinx-induced ER defects by regulating the inflammatory response. +genetics_GWAS 32343915 hsa-mir-1262 Carcinoma, Non-Small-Cell Lung In this study, we hypothesized that the rs12740674 single nucleotide polymorphism in the enhancer of miR-1262 may affect its expression, which may impact the outcome of NSCLC patients treated with EGFR-TKIs. +lncRNA target 32343913 hsa-mir-497 Carcinoma, Renal Cell 5p axis-induced drug resistance phenotypes (cell viability, IC(50), apoptosis) of RCC. +lncRNA target 32343879 hsa-mir-485 Uterine Cervical Neoplasms 5p suppresses the invasion of cancer cells by targeting FLOT-1 in HPV-infected cervical carcinoma cells. +circulation_biomarker_diagnosis_up 32343702 hsa-mir-652 Squamous Cell Carcinoma of Head and Neck 5p in tumour tissues and serum samples of oesophageal squamous cell carcinoma (OSCC) patients were lower compared to non-tumorous tissues and serum samples from healthy subjects, respectively. +other 32343678 hsa-mir-29a Diabetes Mellitus Induction of cZNF532 or antagonism of miR-29a-3p is an exploitable therapeutic approach for the treatment of DR. +other 32343678 hsa-mir-29a Retinal Degeneration Induction of cZNF532 or antagonism of miR-29a-3p is an exploitable therapeutic approach for the treatment of DR. +genetics_knock down_promote 32343603 hsa-mir-485 Colorectal Neoplasms Conclusions: circAPLP2 knockdown inhibited CRC progression through regulating miR +genetics_knock down_promote 32343601 hsa-mir-146b Thyroid Cancer, Papillary The luciferase assay and rescue assay demonstrated that a binding site in miR-146b-5p was existent in the 3' untranslated region of DNMT3A, while a knockdown of DNMT3A partially rescued si-miR-146b-5p induced proliferation, migration, and invasion effects on PTC cells. +lncRNA target 32343508 hsa-mir-99b Brain Ischemia CONCLUSIONS: MiR-99b promoted the viability and suppressed apoptosis of SH-SY5Y cells under OGD/R conditions through targeting IGF1R. +other 32343493 hsa-mir-29c Coronary Disease Finally, six (miR-15b-5p, miR-29c-3p, miR-199a-3p, miR-320e, miR5p and miR-378b) of these 12 miRNAs were verified in validation set-2 with a sensitivity of 92.8% and a specificity of 89.5%, and the AUC was 0.971 (95% confidence interval, 0.948-0.993, P < .001) in a large cohort for CHD patients diagnosis. +other 32343493 hsa-mir-199a Coronary Disease Finally, six (miR-15b-5p, miR-29c-3p, miR-199a-3p, miR-320e, miR5p and miR-378b) of these 12 miRNAs were verified in validation set-2 with a sensitivity of 92.8% and a specificity of 89.5%, and the AUC was 0.971 (95% confidence interval, 0.948-0.993, P < .001) in a large cohort for CHD patients diagnosis. +other 32343493 hsa-mir-320e Coronary Disease Finally, six (miR-15b-5p, miR-29c-3p, miR-199a-3p, miR-320e, miR5p and miR-378b) of these 12 miRNAs were verified in validation set-2 with a sensitivity of 92.8% and a specificity of 89.5%, and the AUC was 0.971 (95% confidence interval, 0.948-0.993, P < .001) in a large cohort for CHD patients diagnosis. +other 32343493 hsa-mir-378b Coronary Disease Finally, six (miR-15b-5p, miR-29c-3p, miR-199a-3p, miR-320e, miR5p and miR-378b) of these 12 miRNAs were verified in validation set-2 with a sensitivity of 92.8% and a specificity of 89.5%, and the AUC was 0.971 (95% confidence interval, 0.948-0.993, P < .001) in a large cohort for CHD patients diagnosis. +other 32343493 hsa-mir-361 Coronary Disease Finally, six (miR-15b-5p, miR-29c-3p, miR-199a-3p, miR-320e, miR5p and miR-378b) of these 12 miRNAs were verified in validation set-2 with a sensitivity of 92.8% and a specificity of 89.5%, and the AUC was 0.971 (95% confidence interval, 0.948-0.993, P < .001) in a large cohort for CHD patients diagnosis. +other 32343493 hsa-mir-15b Coronary Disease Finally, six (miR-15b-5p, miR-29c-3p, miR-199a-3p, miR-320e, miR5p and miR-378b) of these 12 miRNAs were verified in validation set-2 with a sensitivity of 92.8% and a specificity of 89.5%, and the AUC was 0.971 (95% confidence interval, 0.948-0.993, P < .001) in a large cohort for CHD patients diagnosis. +lncRNA target 32343052 hsa-mir-613 Colorectal Neoplasms FAM225A facilitated CRC occurrence and development through positively regulating NOTCH3 expression by binding with miR-613. +other 32342983 hsa-mir-183 Pre-Eclampsia Collectively, our findings suggested that miR-183 may play critical roles in the pathogenesis of PE and serve as a potential biomarker for severe PE. +other 32342645 hsa-mir-513a Carcinoma, Renal Cell Mechanistically, circMYLK can capture miR-513a-5p to facilitate VEGFC expression and further promote the tumorigenesis of RCC cells. In summary, our findings demonstrate that circMYLK has an oncogenic role in RCC growth and metastasis by modulating miR-513a-5p/VEGFC signalling. +lncRNA target 32342557 hsa-mir-146a Pulmonary Disease, Chronic Obstructive CONCLUSION: Lnc-PVT1 assists the disease management and acute exacerbation risk monitoring of COPD via interaction with miR-146a. +circulation_biomarker_diagnosis_ns 32342546 hsa-mir-18a Breast Neoplasms Circulating miR-18a by RNAseq was significantly higher in mammary carcinoma dogs with histologic evidence of lymphatic invasion (P = 0.03). +other 32342519 hsa-mir-1229 Squamous Cell Carcinoma of Head and Neck 3p played a tumor promoting role in HNSCC. +lncRNA target 32342278 hsa-mir-153 Leukemia, Myelogenous, Chronic, BCR-ABL Positive 3p may target Bcl-2 to promote the development of IM resistance and attenuate IM-induced apoptosis in CML. +lncRNA target 32341656 hsa-mir-335 Hepatoblastoma TUG1-miR5p-CXCR4 axis might be a promising immunological target for the treatment of HB patients. +lncRNA target 32341409 hsa-mir-15b Carcinoma, Renal Cell Thus, lncPENG may function as a ceRNA to attenuate miR-15b-dependent PDZK1 downregulation and inhibit cell proliferation, suggesting that it may be clinically valuable as a therapeutic target and a prognostic biomarker of ccRCC. +transcription factor target 32341359 hsa-mir-548t Pancreatic Carcinoma In addition, high miR-548t-5p expression inhibited the proliferation, migration, and invasion of PC cell lines. +transcription factor target 32340512 hsa-mir-25 Polycystic Kidney Diseases Therefore, inhibition of miR +lncRNA target 32340411 hsa-mir-337 Osteochondrodysplasias The inverse relationship between the expression of TWIST1 and miR-337 was finally validated in adipose tissue samples from non-MetS and MetS subjects that demonstrated a dysregulation of the miRTwist1 molecular axis in MetS. +genetics_knock down_promote 32339605 hsa-mir-29 Dihydropyrimidine Dehydrogenase Deficiency Knockdown of PCAT1 suppressed the proliferation and activity, as well as ALP and other DP markers of DP cells by targeting miR-329. CONCLUSION: PCAT1 maintains characteristics of DP cells by targeting miR-329 to activating Wnt/beta-catenin signaling pathway, thereby promoting hair follicle regeneration. +lncRNA target 32339468 hsa-mir-193a Hyperlipidemias Therefore, our findings show that Sdccag3 promotes implant osseointegration, and its related lncRNA-MSTRG.97162.4 and miR-193a-3p play an important role in osseointegration during hyperlipidemia, which might be a promising therapeutic target for improving dental implantation success rates. +lncRNA target 32339345 hsa-mir-199a Angelman Syndrome Quantitative reverse-transcription polymerase chain reaction (qRT-PCR) was used to detect the expression levels of SNHG12 and miR-199a-5p in an in vivo AS model and VSMCs treated by oxidized low-density lipoprotein (ox-LDL). In conclusion, SHNG12 targeting miR-199a-5p/HIF-1alpha contributed to the pathophysiological process of AS by regulating the phenotypes of VSMCs, and could be a potential therapy target for this disease. +lncRNA target 32339330 hsa-mir-143 Gastrointestinal Stromal Tumors PCAT6 promoted GIST cell proliferation and stemness via sponging miR +genetics_overexpression_promote 32339066 hsa-mir-145 Carcinoma, Hepatocellular Overexpression of miR-145 also attenuated HCC cell stemness. +lncRNA target 32338452 hsa-mir-1 Myocardial Infarction In conclusion, modification of DGL-loaded miR-1 inhibitor with LMWH helps overcome microvascular obstruction in delivering the drug to the infarct area, thus providing a promising therapeutic strategy for achieving a better therapeutic outcome of MI. +circulation_biomarker_diagnosis_up 32338289 hsa-mir-202 Essential Hypertension Our study shows that blood miR +genetics_knock down_suppress 32338277 hsa-mir-484 Prostatic Neoplasms Additional in vitro assays with cancer cell lines showed that PSMG1 knockdown rescued the reduction in mobility brought on by miR-484 inhibition, pointing toward the existence of a miR +lncRNA target 32338183 hsa-mir-4260 Leukemia, Myeloid, Acute In conclusion, we firstly uncovered that LINC01128 resisted acute myeloid leukemia through regulating miR-4260/NR3C2, providing novel clues for the treatment improvement of AML. +circulation_biomarker_diagnosis_ns 32338107 hsa-mir-181a Acute Kidney Injury Bioinformatics prediction and western blotting methods validated the targets of miR-181a in vitro.Results: Curcumin treatment alleviated cisplatin-induced nephrotoxicity as validated by the blood urea nitrogen (BUN) values, and histological analysis of kidneys. We verified the direct regulation of PTEN by miR-181a in cultured human embryonic kidney 293T cells.Conclusions: We showed the involvement of miR-181a/PTEN axis in the renoprotective effect of curcumin against cisplatin-induced AKI, and provide new evidence on the ability of curcumin to alleviate cisplatin-induced nephrotoxicity. +other 32337978 hsa-mir-133a Myocardial Infarction, Acute Using Hg(2+) as the ECL signal moderator based on specific interactions between Hg(2+) and thymine-thymine pairs, conjoined with the synthesized g-C(3)N(4)/ABEI/Hg(2+) nanohybrids with outstanding PRECL properties as the sensing interface, a label-free and all-in-one ratiometric ECL bioassay combined with a rolling circle amplification (RCA) strategy was designed for the detection of miR-133a as a biomarker in early diagnosis of acute myocardial infarction (AMI). +lncRNA target 32337959 hsa-mir-155 Neuralgia CONCLUSIONS: Results demonstrate that suppression of miR-155 attenuates neuropathic pain by inducing an M1 to M2 switch in microglia. +circulation_biomarker_diagnosis_up 32337953 hsa-mir-143 Alzheimer Disease 3p is up-regulated in serum of AD patients, yet the exact role it plays in AD pathology is still poorly understood. +lncRNA target 32337949 hsa-mir-223 Ischemic Stroke In conclusion, our findings indicated that FGD5-AS1 may protect the neuron against OGD/R injury via acting as a ceRNA for miR-223 to mediate IGF1R expression, which contributes to a deeper understanding of ischemic stroke and provide a promising therapeutic target for this disease. +lncRNA target 32337949 hsa-mir-223 Osteochondritis Dissecans Simultaneously down-regulating miR-223 and over-expressing FGD5-AS1 as well as IGF1R exhibited an additional effect of extenuating OGD/R damage i.e. In conclusion, our findings indicated that FGD5-AS1 may protect the neuron against OGD/R injury via acting as a ceRNA for miR-223 to mediate IGF1R expression, which contributes to a deeper understanding of ischemic stroke and provide a promising therapeutic target for this disease. +transcription factor target 32337817 hsa-mir-4443 Immunosuppression Therapy Furthermore, transfection with miR-4443 mimic or inhibitor in the monocytes was carried out to gain insight into the mechanisms in SIDS. CONCLUSIONS: The increased expression of miR-4443 induced monocyte dysfunction by targeting TRAF4, which may function as a crucial mediator in SIDS. +other 32337281 hsa-mir-146b Thrombosis The purpose of this study was to investigate the relationship between microRNA-146b-3p (miR-146b-3p) and inflammatory factors in thrombosis. We suggest that the miR-146b-3p/p38MAPK/COX-2 pathway plays a key role in inflammation and arterial thrombosis. +genetics_overexpression_promote 32336973 hsa-mir-186 Atherosclerosis CONCLUSION: Overexpression of miR +genetics_knock down_promote 32336952 hsa-mir-599 Thyroid Carcinoma, Anaplastic Moreover, the repressive effects of NEAT1 knockdown on ATC cell migration, invasion and glycolysis under hypoxia were mediated by miR-206 or miR-599. CONCLUSION: In conclusion, our study suggested that a low NEAT1 expression suppressed the migration, invasion, and glycolysis in ATC cells under hypoxia at least partially through modulating miR-206 and miR-599, providing new therapeutic strategies for ATC treatment. +genetics_knock down_promote 32336952 hsa-mir-206 Thyroid Carcinoma, Anaplastic Moreover, the repressive effects of NEAT1 knockdown on ATC cell migration, invasion and glycolysis under hypoxia were mediated by miR-206 or miR-599. CONCLUSION: In conclusion, our study suggested that a low NEAT1 expression suppressed the migration, invasion, and glycolysis in ATC cells under hypoxia at least partially through modulating miR-206 and miR-599, providing new therapeutic strategies for ATC treatment. +genetics_overexpression_promote 32336590 hsa-mir-20b Retinoblastoma Silencing MALAT1 or overexpressing miR-20b-5p inhibited proliferation and promoted apoptosis in RB cells. +other 32336544 hsa-mir-675 Cartilage Diseases Our findings may substantiate miR3p as a new treatment for OA. +genetics_overexpression_promote 32336285 hsa-mir-615 Breast Neoplasms In breast cancer cell lines, stable overexpression of miR +circulation_biomarker_diagnosis_ns 32336272 hsa-mir-34a Carcinoma, Ovarian Epithelial CONCLUSIONS: Serum exosomal miR-34a could be a potential biomarker for improving the diagnostic efficiency of OC. +other 32336203 hsa-mir-326 Alzheimer Disease Our study aims to investigate the regulation of lncRNA RPPH1 and miR-326/PKM2 on ERS and related apoptosis in AD. +lncRNA target 32336203 hsa-mir-326 Sarcoma, Ewing Mechanistically, RPPH1 directly targeted miR-326, thereby counteracting its inhibitory effect on PKM2 expression, contributing to attenuation of apoptosis and ERS induced by Abeta(25-35). +lncRNA target 32335998 hsa-mir-194 Breast Neoplasms 3p, which targets MECP2. +lncRNA target 32335549 hsa-mir-93 Mycosis Fungoides OBJECTIVE: Here, we provide the first evidence that miR-93 targets the cell cycle regulator cyclin-dependent kinase inhibitor p21 and promotes growth of malignant T cells in MF. +transcription factor target 32335541 hsa-mir-375 Osteoarthritis, Knee It suggests that miR-375 could be considered to be a key therapy target for OA. +genetics_overexpression_promote 32335297 hsa-mir-451a Thyroid Cancer, Papillary ZEB1 overexpression abrogated the inhibitory impacts of miR-451a on PTC cells. +circulation_biomarker_diagnosis_ns 32335272 hsa-mir-129 Amyotrophic Lateral Sclerosis 5p was increased in different models of SOD1-linked ALS and in peripheral blood cells of sporadic ALS patients. +lncRNA target 32335212 hsa-mir-19a Reperfusion Injury, Cerebral Ischemia H19/miR-19a-3p/PTEN axis could promote cerebral I/R injury via PI3K/AKT pathway. +genetics_overexpression_promote 32335083 hsa-mir-216a Diabetic Retinopathy Subsequently, a DR model rat was established, and the target miR-216a was overexpressed to observe the pathological and morphological changes of the rat retina and the levels of inflammatory factors. +genetics_overexpression_suppress 32335050 hsa-mir-342 Breast Neoplasms Overexpression of miR-342 caused remarkable depletion in the expression of CFL1 in MDA-MB-436 breast cancer cells. +other 32335029 hsa-mir-744 Thyroid Cancer, Papillary Moreover, miR5p expression interferes with lncRNA HOTTIP ability to promote proliferation and downregulate apoptosis in papillary thyroid carcinoma. +lncRNA target 32334831 hsa-mir-205 Neoplasms, Multiple Primary Mechanistically, we identified that the lysophosphatidylcholine acyltransferase-1 (LPCAT1) is a novel target of miR-205 in multiple cancer cells. +other 32334684 hsa-mir-21 Hernias, Diaphragmatic, Congenital Therefore, a dependable and low-cost POCT strategy for the detection of miRNA-21 is established, which is promising to supply valuable information for drug screening and evaluation of DIKI. +other 32334684 hsa-mir-21 Drug-Related Side Effects and Adverse Reactions Therefore, a dependable and low-cost POCT strategy for the detection of miRNA-21 is established, which is promising to supply valuable information for drug screening and evaluation of DIKI. +circulation_biomarker_prognosis_ns 32334458 hsa-mir-19a Myocardial Infarction This study aimed at investigating the role of miR-19a as a biomarker with acceptable sensitivity and specificity for early diagnosis of AMI. CONCLUSION: Circulating miR-19a possibly has prognostic value to be used as a promising molecular target for early diagnosis and prognosis of AMI. +other 32334098 hsa-mir-891 Ovarian Neoplasms 5p within sEVs are significantly higher in patients at risk of ovarian cancer relapse. +transcription factor target 32333925 hsa-mir-7 Parkinson Disease Collectively, AST suppressed ER stress and protected against PD-caused neuron damage by targeting miR-7/SNCA axis, implying that AST might be a potential effective therapeutic agent for PD. +lncRNA target 32333305 hsa-mir-132 Stress Disorders, Post-Traumatic The results revealed that miR-132 could modulate PTSD-like behaviors in rats following SPS through regulating FXR1 and FMRP. +lncRNA target 32333234 hsa-mir-876 Glioma 5p suppressed the malignant behaviors of glioma via binding to GSPT1. +lncRNA target 32333091 hsa-mir-767 Carcinoma, Hepatocellular 5p expression levels affect HCC pathogenesis, and to further identify the putative targets. +lncRNA target 32332718 hsa-mir-34c Osteosarcoma Targeting the KCNQ1OT1/miR-34c-5p/ALDOA axis may be a potential therapeutic target in OS treatment. +lncRNA target 32332704 hsa-mir-30 Temporomandibular Joint Disorders Altogether, we elucidated the important roles of a novel circRNA, namely, circGCN1L1, which induced inflammation in TMJ synoviocytes and decreased anabolism of the extracellular matrix (ECM) through miR3p and TNF-alpha gene. +virus_miRNA 32332683 ebv-mir-BART12 Coronary Artery Disease Nine miRNAs (ebv-miR-BART12, ebv-miR-BART16, let-7i-5p, miR-130a-3p, miR-26a-5p, miR-3149, miR-3152-3p, miR-32-3p, and miR-149-3p) were differentially expressed in plasma between severe CAD and control groups +circulation_biomarker_diagnosis_up 32332683 hsa-let-7i Coronary Artery Disease Nine miRNAs (ebv-miR-BART12, ebv-miR-BART16, let-7i-5p, miR-130a-3p, miR-26a-5p, miR-3149, miR-3152-3p, miR-32-3p, and miR-149-3p) were differentially expressed in plasma between severe CAD and control groups +circulation_biomarker_diagnosis_up 32332683 hsa-mir-152 Coronary Artery Disease Nine miRNAs (ebv-miR-BART12, ebv-miR-BART16, let-7i-5p, miR-130a-3p, miR-26a-5p, miR-3149, miR-3152-3p, miR-32-3p, and miR-149-3p) were differentially expressed in plasma between severe CAD and control groups +circulation_biomarker_diagnosis_up 32332683 hsa-mir-149 Coronary Artery Disease Nine miRNAs (ebv-miR-BART12, ebv-miR-BART16, let-7i-5p, miR-130a-3p, miR-26a-5p, miR-3149, miR-3152-3p, miR-32-3p, and miR-149-3p) were differentially expressed in plasma between severe CAD and control groups +circulation_biomarker_diagnosis_up 32332683 hsa-mir-130a Coronary Artery Disease Nine miRNAs (ebv-miR-BART12, ebv-miR-BART16, let-7i-5p, miR-130a-3p, miR-26a-5p, miR-3149, miR-3152-3p, miR-32-3p, and miR-149-3p) were differentially expressed in plasma between severe CAD and control groups +virus_miRNA 32332683 ebv-mir-BART16 Coronary Artery Disease Nine miRNAs (ebv-miR-BART12, ebv-miR-BART16, let-7i-5p, miR-130a-3p, miR-26a-5p, miR-3149, miR-3152-3p, miR-32-3p, and miR-149-3p) were differentially expressed in plasma between severe CAD and control groups +circulation_biomarker_diagnosis_up 32332683 hsa-mir-2 Coronary Artery Disease Nine miRNAs (ebv-miR-BART12, ebv-miR-BART16, let-7i-5p, miR-130a-3p, miR-26a-5p, miR-3149, miR-3152-3p, miR-32-3p, and miR-149-3p) were differentially expressed in plasma between severe CAD and control groups +circulation_biomarker_diagnosis_up 32332683 hsa-mir-26a Coronary Artery Disease Nine miRNAs (ebv-miR-BART12, ebv-miR-BART16, let-7i-5p, miR-130a-3p, miR-26a-5p, miR-3149, miR-3152-3p, miR-32-3p, and miR-149-3p) were differentially expressed in plasma between severe CAD and control groups +other 32332611 hsa-mir-21 Inflammatory Bowel Diseases CONCLUSIONS: This meta-analysis demonstrates that the higher miR-21 expression in colon tissue is positively associated with the development of UC and CD, and miR-21 might serve as a disease marker of IBD. +circulation_biomarker_diagnosis_up 32331943 hsa-mir-146a Multiple Sclerosis In this study, the expression levels of MicroRNA-146a and MicroRNA-155 in 30 serum samples of MS and healthy patients as a control group. +circulation_biomarker_diagnosis_up 32331943 hsa-mir-155 Multiple Sclerosis In this study, the expression levels of MicroRNA-146a and MicroRNA-155 in 30 serum samples of MS and healthy patients as a control group. +lncRNA target 32331846 hsa-mir-338 Liver Failure, Acute 3p inhibited inflammation in APAP-induced acute liver injury. +lncRNA target 32330934 hsa-mir-126 Atrial Myosins Myxoma-derived CSCs possess a mRNA and microRNA transcriptome overall similar to normal myocardium-derived c-kitpos/CD45neg/CD31negCSCs , yet showing a relatively small and relevant fraction of dysregulated mRNA/miRNAs (miR +lncRNA target 32330934 hsa-mir-335 Atrial Myosins Myxoma-derived CSCs possess a mRNA and microRNA transcriptome overall similar to normal myocardium-derived c-kitpos/CD45neg/CD31negCSCs , yet showing a relatively small and relevant fraction of dysregulated mRNA/miRNAs (miR +target gene 32330756 hsa-mir-124 Psoriasis miR124-3p/FGFR2 axis inhibits human keratinocyte proliferation and migration and improve the inflammatory microenvironment in psoriasis. +other 32330263 hsa-mir-17 Oligospermia In contrast, miR-17 approximately 92+/-; miR-106b approximately 25-/- double mutants showed severely disrupted testicular histology and significantly reduced fertility. +other 32330263 hsa-mir-106b Oligospermia In contrast, miR-17 approximately 92+/-; miR-106b approximately 25-/- double mutants showed severely disrupted testicular histology and significantly reduced fertility. +circulation_biomarker_prognosis_ns 32330203 hsa-mir-223 Carcinoma, Hepatocellular In addition, circulating miRNA3p could represent a novel diagnostic and prognostic marker for patients with HBV-related HCC. +other 32329871 hsa-mir-223 Pulmonary Fibrosis The expression of miR-223 decreased with the increase of fibrosis (p<0.05), and the expression level of miR-223 was negatively correlated with the HYP content (p<0.05). +transcription factor target 32329871 hsa-mir-572 Pulmonary Fibrosis CONCLUSIONS: MiR-572 targeted CDH1 to promote cell metastasis in WT by suppressing EMT. +lncRNA target 32329869 hsa-mir-146a Acute Lung Injury CONCLUSIONS: TSA administration exerted anti-inflammation functions in LPS-induced acute lung injury model in vitro, which might be triggered by inhibiting TNF-alpha molecule and upregulating miR-146a expression. +circulation_biomarker_diagnosis_up 32329863 hsa-mir-150 Cerebral Infarction RESULTS: A total of 3,568 differentially expressed miRNAs were detected in the peripheral blood between CI patients and controls, whose 2,100 were upregulated, including miR +lncRNA target 32329857 hsa-mir-29 Neuroblastoma CONCLUSIONS: Depletion of SNHG7 potentiated cisplatin sensitivity through inhibition of autophagy by modulating miR3p/MYO10 axis, providing a new therapeutic approach to overcome cisplatin resistance in NB chemotherapy. +genetics_knock down_suppress 32329856 hsa-mir-548c Breast Neoplasms Similarly, microRNA-548c-5p overexpression remarkably decreased the proliferation ability of BCa cells in vitro. +genetics_knock down_promote 32329854 hsa-mir-19a Carcinoma, Non-Small-Cell Lung Furthermore, FAS-AS1 overexpression restored the promotion of miR-19a-5p overexpression on proliferation, migration, and invasion of NSCLC cells. +genetics_knock down_promote 32329849 hsa-mir-132 Nasopharyngeal Carcinoma Additionally, the result of cell reverse experiment revealed that knockdown of microRNA +lncRNA target 32329848 hsa-mir-146a Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: MiR-146a-5p can inhibit the proliferation and accelerate the apoptosis of OSCC cells by directly targeting NF-kappaB1, and it plays a carcinogenic role in OSCC. +lncRNA target 32329847 hsa-mir-214 Mouth Neoplasms MATERIALS AND METHODS: In this work, human oral cancer HB cell lines were cultured in vitro and then treated with phosphate-buffered saline (PBS) as Control group, with miR-214 mimics as miR-214 mimics group or with miR-214 mimics ERK inhibitor U0126 as miR-214 mimics U0126 group. RESULTS: Compared with Control group, miR-214 mimics group exhibited increased expression of miR-214 in oral cancer cells (p<0.01), extremely raised expression levels of p-ERK and PCNA, but an extremely decreased protein expression level of p21 (p<0.01), whereas miR-214 mimics U0126 group had remarkably lower levels of p-ERK and PCNA, and a considerably higher protein level of p21 than miR-214 mimics group (p<0.05). +transcription factor target 32329846 hsa-mir-27a Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: FBXW7 was mediated by miR-27a and could inhibit the proliferation through the PI3K/AKT pathway and invasion-mediated EMT in OSCC cell line. +genetics_knock down_promote 32329843 hsa-mir-384 Esophageal Squamous Cell Carcinoma MiR-384 depletion and FN1 upregulation weakened the effects of circCNOT6L knockdown and miR-384 overexpression on ESCC cell progression, respectively. +genetics_overexpression_promote 32329842 hsa-mir-129 Stomach Neoplasms HMGB1 overexpression overtly reversed the inhibitory effect of miR +genetics_knock down_promote 32329840 hsa-mir-200b Stomach Neoplasms In addition, the silence of microRNA-200b could reverse the biological function of GCa cells induced by the knockout of LINC01857. +lncRNA target 32329834 hsa-mir-363 Carcinoma, Hepatocellular Moreover, rescue experiments indicated that SNHG5 silence inhibited the progression of HCC cells by regulating miR +lncRNA target 32329829 hsa-mir-145 Uterine Cervical Neoplasms Lnc-RNA UCA1 regulates cervical cancer cell proliferation, migration, and invasion by targeting miR-145. +lncRNA target 32329826 hsa-mir-204 Retinoblastoma CONCLUSIONS: Our current study suggested that XIST silencing suppressed RB progression and promoted VCR sensitivity in vitro and in vivo at least partially by acting as a miR +genetics_overexpression_promote 32329825 hsa-mir-654 Osteosarcoma Meanwhile, the overexpression of miR +lncRNA target 32329824 hsa-mir-32 Multiple Myeloma CONCLUSIONS: MiR-32 targeting PTEN will have certain effects on the proliferation and apoptosis of myeloma cells. +lncRNA target 32329821 hsa-mir-34 Cataract CONCLUSIONS: MiR-34 can promote the apoptosis in lens epithelial cells of cataract rats via the TGF-beta/Smads signaling pathway. +lncRNA target 32329819 hsa-mir-296 Osteoarthritis 5p inhibitors enhanced the effect of si-CircPSM3 on the proliferation and differentiation of OA chondrocytes. +lncRNA target 32329818 hsa-mir-93 Osteoporosis, Postmenopausal 5p to upregulate BMP2, thus alleviating the progression of PMOP. +other 32329809 hsa-mir-375 Nasopharyngeal Carcinoma "The article ""Long noncoding RNA ROR1-AS1 induces tumor metastasis and epithelial-mesenchymal transition by sponging miR-375 in nasopharyngeal carcinoma, by Hou J, Yan J, Ren XY, Zhu K, Du XY, Li JJ, Xu M., published in Eur Rev Med Pharmacol Sci." +lncRNA target 32329692 hsa-mir-34a Carcinoma, Hepatocellular Isovitexin Inhibits Stemness and Induces Apoptosis in Hepatocellular Carcinoma SK-Hep-1 Spheroids by Upregulating miR-34a Expression. OBJECTIVE The current study was to examine whether ISOV regulates the miR-34a expression and hence suppresses the stemness of HCC SK-Hep-1 cells. +lncRNA target 32329664 hsa-mir-3163 Carcinoma, Hepatocellular In the first place, qRT-PCR found that OIP5-AS1 and VEGFA expressions were significantly increased while miR-3163 was obviously reduced in HCC cells and tissues. In summary, OIP5-AS1 affects HCC proliferation, metastasis, and angiogenesis in HCC by regulating VEGFA expression through sponging miR-3163. +lncRNA target 32329653 hsa-mir-21 Reperfusion Injury, Renal Ischemia Taken together, MSC-MVs inhibit tubular epithelial cell apoptosis and ameliorate renal IRI, at least partially, via delivery of miR-21. +transcription factor target 32329577 hsa-mir-22 Spinal Dysraphism CONCLUSION: miR-322/NOX4 plays a crucial role in apoptosis-induced NTD formation, which may provide a new understanding of the mechanism of embryonic NTDs and a basis for potential therapeutic target against NTDs. +circulation_biomarker_diagnosis_ns 32329505 hsa-mir-210 Lung Neoplasms The biosensing potential of the cm(2)-sized nanostructured plasmonic sensor chips has been evaluated for the detection of miRNA-210, a relevant biomarker for lung cancer diagnosis, through a DNA/miRNA hybridization assay. +transcription factor target 32329448 hsa-mir-28 Atherosclerosis CONCLUSIONS MiR3p protected vascular endothelial cells against ox-LDL induced injury via targeting FOXO4, suggesting a novel insight for atherosclerosis treatment. +target gene 32329296 hsa-mir-1294 Uterine Cervical Neoplasms MiR-1294 acts as a tumor inhibitor in cervical cancer by regulating FLOT1 expression. +other 32329295 hsa-mir-206 Nasopharyngeal Carcinoma The newly identified miR-206/G6PD axis provides novel insight into the pathogenesis of nasopharyngeal carcinoma. +lncRNA target 32329288 hsa-mir-130a Hypertrophy The mimics and inhibitors of miR-130a-3p were transfected into H9c2 cells to observe the role of miR-130a-3p on the hypertrophic phenotype change of cardiomyocytes separately. +transcription factor target 32329288 hsa-mir-130a Cardiomegaly This study aimed to explore the role of miR-130a-3p in cardiomyocyte hypertrophy and its underlying mechanisms. These results suggest that miR-130a-3p mimics may alleviate the degree of cardiomyocyte hypertrophy, meanwhile its inhibitor can further aggravate cardiomyocyte hypertrophy. +lncRNA target 32328683 hsa-mir-146a Osteoarthritis RESULTS The microRNA array demonstrated that miR-146a-5p was significantly upregulated in osteoarthritic tissues, which was further confirmed by PCR analysis. CONCLUSIONS This work showed that miR-146 induces chondrocyte apoptosis by targeting the TRAF6-mediated NF-KB signaling pathway, and miR-146 may be a potential target for OA treatment. +lncRNA target 32328683 hsa-mir-146 Osteoarthritis RESULTS The microRNA array demonstrated that miR-146a-5p was significantly upregulated in osteoarthritic tissues, which was further confirmed by PCR analysis. CONCLUSIONS This work showed that miR-146 induces chondrocyte apoptosis by targeting the TRAF6-mediated NF-KB signaling pathway, and miR-146 may be a potential target for OA treatment. +other 32328453 hsa-mir-7977 Adenocarcinoma of Lung Results: CSF miR-7975, miR-7977, and miR-7641 were screened and verified to be statistically significantly up-regulated in LM patients compared to non-LM controls. Longitudinal data of CSF miR-7975 and miR-7977 correlated well with clinical courses of LM. +circulation_biomarker_diagnosis_up 32328349 hsa-mir-433 Stomach Neoplasms CONCLUSIONS: Our study reveals the potential therapeutic use of two serum-based biomarkers, miR +circulation_biomarker_diagnosis_up 32328349 hsa-mir-9 Stomach Neoplasms CONCLUSIONS: Our study reveals the potential therapeutic use of two serum-based biomarkers, miR +genetics_knock down_suppress 32328195 hsa-mir-944 Nasopharyngeal Carcinoma Rescue experiments showed that miR-944 inhibitors or MDM2 overexpression reserved the effects of circSERPINA3 knockdown on NPC progression. Therefore, our study uncovered the circSERPINA3/miR-944/MDM2 axis in NPC, which may be a potential NPC therapeutic target. +lncRNA target 32328191 hsa-mir-93 Squamous Cell Carcinoma of Head and Neck 5p were partly mediated by targeting RGMB, whose downregulation also promoted the migration and invasion of SCCHN. +lncRNA target 32328182 hsa-mir-891a Breast Neoplasms 5p are the potential targets for HR-positive breast cancer therapeutics. +lncRNA target 32327666 hsa-mir-4476 Glioma In conclusion, our study demonstrates that miR-4476 acts as a tumor enhancer, directly targeting APC to stimulate its own expression and promoting the malignant phenotypes of glioma. +circRNA target 32327630 hsa-mir-31 Melanoma 3p reversed the inhibitory effect of si-circ_0002770 on melanoma cell proliferation and invasion. +exosome 32327611 hsa-mir-142 Endomyocardial Fibrosis Thus, CD4-activated Exos promote post-ischemic cardiac fibrosis through exosomal miR3p-WNT signaling cascade-mediated activation of myofibroblasts. +transcription factor target 32327611 hsa-mir-142 Adenomatous Polyposis Coli Furthermore, miR3p directly targeted and inhibited the expression of Adenomatous Polyposis Coli (APC), a negative WNT signaling pathway regulator, contributing to the activation of WNT signaling pathway and cardiac fibroblast activation. +transcription factor target 32327611 hsa-mir-142 Atrial Premature Complexes Furthermore, miR3p directly targeted and inhibited the expression of Adenomatous Polyposis Coli (APC), a negative WNT signaling pathway regulator, contributing to the activation of WNT signaling pathway and cardiac fibroblast activation. +exosome 32327611 hsa-mir-142 Heart Diseases 3p in CD4-activated Exos may hold promise for treating cardiac remodeling post-MI. +exosome 32327611 hsa-mir-142 Cardiomyopathies Thus, CD4-activated Exos promote post-ischemic cardiac fibrosis through exosomal miR3p-WNT signaling cascade-mediated activation of myofibroblasts. +lncRNA target 32327260 hsa-mir-139 Stomach Neoplasms 5p/RPRD1B/tumor proliferation axis in GC, which may serve as novel biomarkers and drug targets for GC. +exosome 32326590 hsa-mir-155 Parkinson Disease EV-cargo was further assessed for deiminated proteins as well as three key micro-RNAs known to contribute to inflammation and hypoxia (miR21, miR155, and miR210) and also associated with PD. +exosome 32326590 hsa-mir-210 Parkinson Disease EV-cargo was further assessed for deiminated proteins as well as three key micro-RNAs known to contribute to inflammation and hypoxia (miR21, miR155, and miR210) and also associated with PD. +exosome 32326590 hsa-mir-21 Parkinson Disease EV-cargo was further assessed for deiminated proteins as well as three key micro-RNAs known to contribute to inflammation and hypoxia (miR21, miR155, and miR210) and also associated with PD. +other 32326527 hsa-mir-146a Arthritis, Psoriatic COL6A5 and COL8A1 take part in the proliferation and angiogenic pathways which are altered in Ps/PsA and contribute to inflammation together with MIR146A. +other 32326527 hsa-mir-146a psoriasis 1 COL6A5 and COL8A1 take part in the proliferation and angiogenic pathways which are altered in Ps/PsA and contribute to inflammation together with MIR146A. +transcription factor target 32326395 hsa-mir-296 Nasopharyngeal Carcinoma We demonstrate that miR-296 is involved in the inhibitory effects of EGCG on the anoikis-resistant NPC cells through the downregulation of signal transducer and activator of transcription 3 (STAT3) activation. Our results indicate the novel effects of EGCG on miRNA regulation to inhibit an invasive phenotype of NPC as well as the regulatory role of miR-296. +other 32326380 hsa-mir-101 Influenza, Human Collectively, the data suggest a novel mechanism that IAV stimulates mTOR pathway at early stages of infection; however, at a later time-point, positive regulation of miR-101 restrains the mTOR expression, and hence, the viral propagation. +other 32326378 hsa-mir-422a Squamous Cell Carcinoma of Head and Neck We provide novel findings that deregulated miR-21, miR-155, and miR-422a and MMR gene expression patterns may be valuable biomarkers for lung and head and neck squamous cell cancer progression in smokers. +other 32326378 hsa-mir-155 Squamous Cell Carcinoma of Head and Neck We provide novel findings that deregulated miR-21, miR-155, and miR-422a and MMR gene expression patterns may be valuable biomarkers for lung and head and neck squamous cell cancer progression in smokers. +other 32326378 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck We provide novel findings that deregulated miR-21, miR-155, and miR-422a and MMR gene expression patterns may be valuable biomarkers for lung and head and neck squamous cell cancer progression in smokers. +lncRNA target 32326325 hsa-mir-150 Endotoxemia In conclusion, we show that miR-150 is downregulated in experimental endotoxemia and can predict survival in sepsis but is unaffected by P2Y(12) inhibition. +other 32325871 hsa-mir-132 von Hippel-Lindau Disease Although upregulation of the miR-212/132 family and disturbed VHL signaling have both been linked with angiogenesis, no evidence of a possible connection between the two has yet been made. +other 32325871 hsa-mir-212 von Hippel-Lindau Disease Although upregulation of the miR-212/132 family and disturbed VHL signaling have both been linked with angiogenesis, no evidence of a possible connection between the two has yet been made. +other 32325711 hsa-mir-1271 Schizophrenia In this case, we investigated the transcriptome-wide impact of schizophrenia-associated miR5p in response to bidirectional modulation. +other 32325539 hsa-mir-26b Squamous Cell Carcinoma of Head and Neck SIGNIFICANCE OF THE STUDY: We first uncovered that Response Gene to Complement-32 played a significantly pro-tumorigenic role in tongue squamous cell carcinoma (TSCC), which was closely regulated by downregulation of miR-26b and activations of epithelial-mesenchymal transition process and PI3K/AKT signalling. +genetics_knock down_suppress 32325430 hsa-mir-708 Osteosarcoma Both miR-708 knockdown and URGCP restoration partially neutralized anticancer activities of LINC00514 silencing in OS cells. LINC00514 increases URGCP expression by acting as a competing endogenous RNA for miR-708, thus exerting oncogenic roles in OS progression. +lncRNA target 32325349 hsa-mir-138 Fatty Liver CONCLUSIONS: GJLZ is an effective formula for NAFLD management, and its possible mechanism of action involves the regulation of CPT1B expression via rno-miR5p. +lncRNA target 32325132 hsa-mir-1236 Osteoarthritis SIGNIFICANCE: These data enhance our understanding on the role of miR-1236 in OA and identifies miR-1236 as a potential biomarker or possible treatment target within OA. +other 32325105 hsa-mir-142 psoriasis 1 These findings provide a new and better understanding of the mediating role of miR3p in psoriasis. +other 32325088 hsa-mir-190a Esophageal Squamous Cell Carcinoma Therefore, these findings suggest that LINC01980 may act as an oncogenic lncRNA in ESCC and LINC01980/miR-190a-5p/MYO5A pathway contributes to the development of ESCC. +genetics_overexpression_suppress 32324970 hsa-mir-483 Hypertension, Pulmonary Rats with EC-specific miR-483 overexpression exhibited ameliorated pulmonary hypertension (PH) and reduced right ventricular hypertrophy on challenge with monocrotaline (MCT) or Sugen hypoxia. +other 32324343 hsa-mir-23b Carcinoma, Hepatocellular Low SNHG16 and high miR-23b-3p were related to a high survival rate of HCC patients. +lncRNA target 32324311 hsa-mir-450b Glioblastoma In conclusion, GSN, which inhibits cell proliferation and invasion, is suppressed by miR +lncRNA target 32324311 hsa-mir-654 Glioblastoma In conclusion, GSN, which inhibits cell proliferation and invasion, is suppressed by miR +lncRNA target 32323859 hsa-mir-218 Carcinoma, Non-Small-Cell Lung Furthermore, microRNA218 (miR218) was confirmed as an effective target of lncRNACCAT1 in NSCLC. lncRNACCAT1 enhances tumor growth in NSCLC by directly inhibiting miR218 and indirectly increasing BMI1 expression. +other 32323857 hsa-mir-155 Esophageal Neoplasms The present study revealed that miR1555p may be involved in esophageal squamous cell carcinoma (ESCC). Overall, the results of the present study demonstrated that miR1555p is a key molecule for understanding the heterogeneous responses of ESCC to chemoradiotherapy, and may be used in personalized treatment plans for this high mortality tumor in the future. +exosome 32323853 hsa-mir-29c Stomach Neoplasms The expression of miR29a3p, miR29b3p and miR29c3p in peritoneal exosomes were all downregulated in patients with peritoneal metastases (PM) compared to those without PM. +exosome 32323853 hsa-mir-29 Stomach Neoplasms In the present study, exosomes were isolated from peritoneal lavage fluid or ascites in 85 patients with gastric cancer and the relative expression levels of miR29s were examined. +exosome 32323853 hsa-mir-29b Stomach Neoplasms The expression of miR29a3p, miR29b3p and miR29c3p in peritoneal exosomes were all downregulated in patients with peritoneal metastases (PM) compared to those without PM. +exosome 32323853 hsa-mir-29a Stomach Neoplasms The expression of miR29a3p, miR29b3p and miR29c3p in peritoneal exosomes were all downregulated in patients with peritoneal metastases (PM) compared to those without PM. +lncRNA target 32323846 hsa-mir-573 Breast Neoplasms The present study demonstrated that SNHG1 acts as a novel oncogene in breast cancer via the SNHG/miR573/LMO4 axis and that it could be a promising therapeutic target for patients with breast cancer. +genetics_knock down_promote 32323827 hsa-mir-363 Retinoblastoma Knockdown of PIK3CA increased the anticancer effects of miR3633p in RB cells. +genetics_knock down_promote 32323821 hsa-let-7e Osteoarthritis, Knee Therefore, the present study provided additional evidence that circulating let7e may be a potential serum biomarker for the diagnosis and treatment of KOA. +lncRNA target 32323808 hsa-mir-126 Uterine Cervical Neoplasms Hence, high levels of miR1263p may inhibit cervical carcinogenesis, and targeting the PI3K/PDK1/AKT pathway via miR1263p could represent a new approach for treating patients with cervical cancer. +other 32323808 hsa-mir-126 Precancerous Conditions We previously reported that relative to normal cervical mucus, microRNA 1263p (miR1263p) is present in significantly greater amounts in the cervical mucus of patients with overt cervical cancer or precursor lesions. +other 32323801 hsa-mir-146a Breast Neoplasms METTL14 modulates m6A modification and hsamiR146a5p expression, thereby affecting the migration and invasion of breast cancer cells. +transcription factor target 32323800 hsa-mir-421 Carcinoma, Non-Small-Cell Lung In addition, qPCR analysis showed that miR421 was upregulated in NSCLC cell lines, with the bioinformatics analysis, western blot analysis and DualLuciferase reporter assay, it was determined that miR421 could target ORP8. +lncRNA target 32323798 hsa-mir-28 Carcinoma, Non-Small-Cell Lung Using a dualluciferase reporter assay and western blot analysis, it was further validated that TPTEP1 sponged miR3285p to upregulate Src kinase signaling inhibitor 1 (SRCIN1) in NSCLC cells. +transcription factor target 32323794 hsa-mir-95 Osteosarcoma Our results help clarify the mechanism underlying the miR95mediated effects on OS tumor growth, thus potentially establishing it as a diagnostic target. +genetics_knock down_promote 32323793 hsa-mir-25 Colorectal Neoplasms Reduction of miR253p expression with an inhibitor significantly attenuated the biological effects of LINC00858 knockdown in CRC cells. Collectively, the results from the present study, to the best of our knowledge, firstly demonstrated a novel LINC00858/miR253p/SMAD7 regulatory axis that promoted CRC progression, indicating LINC00858 as a promising therapeutic target for CRC. +other 32323787 hsa-mir-590 Neovascularization, Pathologic Thus, the lncRNA NORAD/miR5903p axis may be a novel regulatory pathway in the angiogenic mechanisms in HUVECs, which highlights a potentially novel perspective for treating ischemia/hypoxiainduced angiogenic diseases. +other 32323787 hsa-mir-590 Ischemia Thus, the lncRNA NORAD/miR5903p axis may be a novel regulatory pathway in the angiogenic mechanisms in HUVECs, which highlights a potentially novel perspective for treating ischemia/hypoxiainduced angiogenic diseases. +genetics_overexpression_suppress 32323786 hsa-mir-34a Colorectal Neoplasms It was revealed that miR34a expression levels were significantly decreased while SIRT1 was overexpressed in most of the CRC tissues and all the CRC cell lines. +other 32323783 hsa-mir-23a Carcinoma, Hepatocellular The differential expression of hsa_circRNA_100084, hsamiR23a5p and IGF2 in HCC tissues and liver cancer cells was validated by reverse transcriptionquantitative PCR. The results show that hsa_circRNA_100084 could promote the expression of IGF2 by acting as a sponge of hsamiR23a5p in liver cancer cells. +lncRNA target 32323781 hsa-mir-22 Osteosarcoma It was also convincingly demonstrated that miR22 mediates the CDDP resistance of OS by inhibiting autophagy via the PI3K/Akt/mTOR pathway. +lncRNA target 32323771 hsa-mir-200a Esophageal Squamous Cell Carcinoma The association between miR200a and the 3'untranslated region of target genes in ESCC cells was confirmed using a dualluciferase reporter assay. +transcription factor target 32323769 hsa-mir-296 Glioblastoma The present study indicated an increase in miR2963p in glioma tumor types compared with normal brain, particularly in the samples from patients with high grade GBM. In conclusion, the present study identified an oncogenic function of miR2963p in glioblastoma via the direct regulation of ICAT. +transcription factor target 32323768 hsa-mir-526b Myocardial Injury In conclusion, the present study highlights the role of autophagy in sepsisinduced AKI, and miR526b in regulating autophagy through targeting ATG7, which suggested that miR526b may be a molecular therapeutic target for sepsisinduced AKI. +transcription factor target 32323768 hsa-mir-526b Acute Kidney Injury In conclusion, the present study highlights the role of autophagy in sepsisinduced AKI, and miR526b in regulating autophagy through targeting ATG7, which suggested that miR526b may be a molecular therapeutic target for sepsisinduced AKI. +lncRNA target 32323747 hsa-mir-155 Myocardial Injury In conclusion, the results of the present study suggested that CASC2 may serve as a potential target for treating sepsisinduced AKI by inhibiting the miR155 and NFkappaB pathwaymediated inflammation. +lncRNA target 32323747 hsa-mir-155 Acute Kidney Injury In conclusion, the results of the present study suggested that CASC2 may serve as a potential target for treating sepsisinduced AKI by inhibiting the miR155 and NFkappaB pathwaymediated inflammation. +lncRNA target 32323741 hsa-mir-145 Osteosarcoma Increased miR1455p expression inhibited the proliferation and colony formation ability of osteosarcoma cells, and induced G1 phase arrest. +transcription factor target 32323738 hsa-mir-21 Vascular Endothelial Damage In conclusion, the present results indicated that geniposide protects HUVECs from oxLDL injury by inhibiting oxidative stress and inflammation, and that these effects are partly due to the enhancement of the miR21/PTEN pathway. +transcription factor target 32323738 hsa-mir-21 Wounds and Injuries In conclusion, the present results indicated that geniposide protects HUVECs from oxLDL injury by inhibiting oxidative stress and inflammation, and that these effects are partly due to the enhancement of the miR21/PTEN pathway. +circulation_biomarker_diagnosis_up 32323261 hsa-mir-27b Intracranial Aneurysm Plasma miR-146a-5p and miR-27b-3p were associated with clinical outcomes in patients with aSAH. +circulation_biomarker_diagnosis_up 32323261 hsa-mir-146a Intracranial Aneurysm Plasma miR-146a-5p and miR-27b-3p were associated with clinical outcomes in patients with aSAH. +other 32323148 hsa-mir-21 Prostatic Neoplasms 3p should be considered as potential urinary biomarkers for the diagnosis of PCa. +other 32323148 hsa-mir-141 Prostatic Neoplasms 3p should be considered as potential urinary biomarkers for the diagnosis of PCa. +other 32323148 hsa-mir-574 Prostatic Neoplasms 3p should be considered as potential urinary biomarkers for the diagnosis of PCa. +other 32323148 hsa-mir-375 Prostatic Neoplasms 3p should be considered as potential urinary biomarkers for the diagnosis of PCa. +transcription factor target 32323054 hsa-mir-10b Ischemic Stroke Besides, expression of SHNG16 and BDNF were both downregulated while miR-10b-5p was upregulated in MCAO brain tissues or OGD treated neurons. In conclusion, DEX exerts neuroprotective in ischemic stroke via improving neuron damage, the underlying mechanism may be upregulating SHNG16 and BDNF via sponging miR-10b-5p. +genetics_overexpression_promote 32322665 hsa-mir-140 Melanoma Additionally, overexpression of miR +other 32322310 hsa-mir-23b Wilms Tumor METHODS: The expression levels of PVT1, miR-23b-3p, and Wilms tumor protein 1 (WT1) mRNA were assessed by quantitative real-time polymerase chain reaction (qRT-PCR). +genetics_GWAS 32321821 hsa-mir-142 Tuberculosis In summary, we identified a functional SNP (rs13120371) in the xCT 3' UTR region that increases susceptibility to TB through interacting with miR3p.IMPORTANCE Tuberculosis (TB) is the leading cause of death from a single infectious agent globally, and the development of multidrug resistance represents a serious health concern, particularly in the developing world. +transcription factor target 32321642 hsa-mir-340 Inflammatory Bowel Diseases "Our findings suggest that miR-340 negatively affects SAU inhibition of Th17 differentiation and might play a crucial role in the regulation of pathogenic ""Th1-like"" Th17 cell generation, which might serve as a novel therapeutic target of IBD." +transcription factor target 32321579 hsa-mir-124a Osteoarthritis miR-124A might play an important role in progression of OA through targeting QKI and MAP 1B. +epigenetics 32321346 hsa-mir-125a Lupus Erythematosus, Systemic Hsa_circ_0012919 regulated the expression and methylation of MDA5 in the CD4+ T cells of SLE patients, and hsa_circ_0012919 could regulate MDA5 by miR-125a-3p. +transcription factor target 32321315 hsa-mir-153 Lupus Erythematosus, Systemic 3p is a mediator of SLE UC-MSCs regulation and may function as a new therapeutic target for the treatment of lupus. +circRNA target 32321304 hsa-mir-1180 Multiple Myeloma Circ-CDYL could absorb miR-1180 and alleviated the repression of miR-1180 on YAP, leading to increased YAP expression, ultimately triggering MM uncontrolled growth. +circulation_biomarker_diagnosis_up 32321279 hsa-mir-887 Respiratory Distress Syndrome Circulating miR +genetics_overexpression_promote 32321153 hsa-mir-4290 Stomach Neoplasms Moreover, miR-4290 significantly inhibited glycolysis and decreased the IC50 value to cisplatin in SGC7901 cells, whereas these effects were abolished and cell apoptosis was promoted when PDK1 was overexpressed. +circulation_biomarker_diagnosis_up 32321013 hsa-mir-1273g Carcinoma, Ductal, Breast The results showed the plasma miR-1273g-3p level were significantly up-regulated in breast ductal cancer patients compared with healthy donors (p=0.0139). +lncRNA target 32320934 hsa-mir-185 Asphyxia Further work indicated that CYP4A11 is a putative target gene of miR-3185 and expressed at a relatively low level in cardiac tissue specimens from cases of mechanical asphyxia compared with specimens from cases of craniocerebral injury, hemorrhagic shock, sudden cardiac death and poisoning. +lncRNA target 32320856 hsa-mir-296 Carcinoma, Hepatocellular 5p exerts an inhibitory effect on stemness potency of HCC cells via Brg1/Sall4 axis. +genetics_overexpression_promote 32320818 hsa-mir-129 Polycystic Ovary Syndrome Down-regulated lncRNA ZFAS1 or overexpressed miR-129 could decrease HMGB1 expression, increase P4 and E2 secretion, promote proliferation activity while inhibit apoptosis of ovarian granulosa cells in PCOS. +genetics_overexpression_promote 32320818 hsa-mir-129 Endocrine System Diseases Down-regulated lncRNA ZFAS1 or overexpressed miR-129 could decrease HMGB1 expression, increase P4 and E2 secretion, promote proliferation activity while inhibit apoptosis of ovarian granulosa cells in PCOS. +target gene 32320719 hsa-mir-16 Alzheimer Disease miR-16-5p is upregulated by amyloid β deposition in Alzheimer's disease models and induces neuronal cell apoptosis through direct targeting and suppression of BCL-2. +lncRNA target 32320706 hsa-mir-106a Pre-Eclampsia HOTAIR significantly repressed miR-106a expression and the reduced miR-106a level was also observed in placentas from PE patients. SIGNIFICANCE: High level of HOTAIR repressed the proliferation, migration and invasion of trophoblast cells through targeting miR-106 in an EZH2-dependent manner, which may provide new insights into the roles of HOTAIR and miR-106a as potential regulators in PE. +lncRNA target 32320706 hsa-mir-106 Pre-Eclampsia HOTAIR significantly repressed miR-106a expression and the reduced miR-106a level was also observed in placentas from PE patients. SIGNIFICANCE: High level of HOTAIR repressed the proliferation, migration and invasion of trophoblast cells through targeting miR-106 in an EZH2-dependent manner, which may provide new insights into the roles of HOTAIR and miR-106a as potential regulators in PE. +genetics_overexpression_suppress 32319862 hsa-mir-10a Leukemia, Myeloid, Acute Therefore, this study was performed to analyze the interaction between SNHG4 and miR-10a in AML.Methods: We included 60 patients with AML and 60 healthy participants. Cell proliferation analysis showed that SNHG4 and PTEN overexpression led to decreased proliferation rates of AML cells and attenuated the enhancing effects of miR-10a on cell proliferation.Conclusion: In conclusion, SNHG4 may regulate miR-10a/PTEN to inhibit the proliferation of AML cells. +lncRNA target 32319822 hsa-mir-543 Carcinoma, Non-Small-Cell Lung Conclusions: In conclusion, SNHG10 sponges miR-543 to upregulate tumor suppressive SIRT1 in NSCLC to suppress cell proliferation. +lncRNA target 32319820 hsa-mir-205 Uterine Cervical Neoplasms Conclusion: Upregulation of WT1-AS suppressed CC development through sponging miR-205, providing experimental basis for clinical targeted treatment of CC. +genetics_knock down_promote 32319789 hsa-mir-20a Breast Neoplasms Results: Expression of HNF1A-AS1 and TRIM32 was upregulated and miR-20a-5p was downregulated in breast cancer tumors and cell lines. Conclusions: Knockdown of HNF1A-AS1 suppressed breast carcinogenesis presumably through targeting miR-20a-5p/TRIM32 axis, suggesting that HNF1A-AS1 might be a promising therapy target for breast cancer. +genetics_overexpression_promote 32319715 hsa-mir-1224 Glioblastoma 5p attenuated the enhancement in GBM cell proliferation and invasion induced by MIR4435-2HG overexpression. +transcription factor target 32319664 hsa-mir-138 Spinal Cord Injuries These results indicated that miR1385p could regulate inflammatory responses and cell apoptosis in SCI models by modulating the PTEN/AKT signaling pathway via SIRT1, thus playing an important role in the development of SCI. +genetics_overexpression_promote 32319642 hsa-mir-93 Myocardial Infarction Furthermore, it was found that miR93 overexpression significantly suppressed Lats2 expression and decreased the levels of phosphorylated Yap in the myocardium after MI. +lncRNA target 32319638 hsa-mir-125a Diabetes Mellitus, Experimental Using a rat model of streptozotocininduced diabetes mellitus, it was demonstrated that miR125a expression was gradually downregulated, and that the expressions of key enzymes in the mevalonate signaling pathway in the aortic media were dysregulated after several weeks. +transcription factor target 32319630 hsa-mir-200a Liver Cirrhosis Taken together, these results indicated that downregulation of miR200a might enhance the formation of liver fibrosis, probably by targeting Gli3, and elevated miR200a may attenuate the progression of liver fibrosis by suppressing Gli3. These findings suggested that miR200a may function as a novel anti fi brotic agent in liver fibrosis via inhibition of the expression of Gli3. +transcription factor target 32319614 hsa-mir-193a Osteomyelitis Furthermore, hsamiR193a3p was demonstrated to induce BN by targeting MAPK10. Collectively, the results of the present study suggest that hsamiR193a3p may be a viable biomarker of BN. +circRNA target 32319610 hsa-mir-665 Squamous Cell Carcinoma of Head and Neck The present results suggested that circRNAs may be involved in TSCC development, and understanding the interaction between circ_081069 and miR665 may facilitate the development of novel diagnostic and therapeutic targets for TSCC. +lncRNA target 32319598 hsa-mir-205 Endometrial Neoplasms LA16c313D11.11 was shown to regulate the expression of PTEN, and the invasion, migration and viability of HEC1A and Ishikawa cells, through its microRNA response element to compete for microRNA2055p. +circRNA target 32319577 hsa-mir-1297 Triple Negative Breast Neoplasms The current results indicate that miR1297 serves as a suppressor of breast cancer cell proliferation and invasiveness, and that this can be partially reversed by hsa_circ_0091074, suggesting that the hsa_circ_0091074/miR1297/TAZ/TEAD4 axis may represent a potential therapeutic target for triple negative breast cancer in the future. +transcription factor target 32319576 hsa-mir-210 Uterine Cervical Neoplasms Thus, it was hypothesized that HECTD1 may regulate EMT through the hypoxia/hypoxia inducible factor 1alpha/miR210/HECTD1/SNAIL signaling pathway and the EGF/EGF receptor/HECTD1/ERK/SNAIL signaling pathway in cervical cancer. +lncRNA target 32319565 hsa-mir-574 Triple Negative Breast Neoplasms miR5745p targeted BCL11A and SOX2 to inhibit the SKIL/transcriptional coactivator with PDZbinding motif/connective tissue growth factor axis, and the inhibitory effect of miR5745p in TNBC cells was at least partly dependent on SOX2 and BCL11A. +genetics_overexpression_promote 32319564 hsa-mir-21 Urinary Bladder Neoplasms The data of the current study may indicate that miR21 overexpression inhibited autophagy and promoted the proliferation, migration, invasion and epithelial to mesenchymal transition of bladder cancer T24 cells. +exosome 32319558 hsa-mir-21 Pancreatic Carcinoma Collectively, these results suggested that PSCderived exosomal miR21 may promote PDAC cell migration and EMT and enhance Ras/ERK signaling activity. +lncRNA target 32319551 hsa-mir-93 Intervertebral Disc Degeneration Thus, the results of the present study demonstrated that PART1 may regulate NP cell degeneration through the miR93/MMP2 pathway. +genetics_overexpression_promote 32319545 hsa-mir-342 Osteosarcoma The reduction of miR3423p reversed the effects of CircSAMD4A downregulation on cell cytotoxicity, migration, invasion, apoptosis and EMT in OS, while FZD7 overexpression blocked the effect of miR3423p upregulation on OS progression. +genetics_knock down_promote 32319544 hsa-mir-1261 Liver Neoplasms Consistently, overexpression of ANAPC11 or inhibition of miR1261 significantly rescued liver cancer cell proliferation induced by knockdown of lncRNA BCAR4. Collectively, the results of the present study demonstrated that lncRNA BCAR4 may promote liver cancer development by directly binding to miR1261 and targeting ANAPC11. +lncRNA target 32319541 hsa-mir-346 Pneumonia, Mycoplasma Moreover, LRP6 was predicted to be the target gene for microRNA (miR)346, which was highly expressed in PE tissues and trophoblast cell lines. +genetics_overexpression_suppress 32319540 hsa-mir-25 Carcinoma, Hepatocellular Further studies showed that Sevo's inhibitory actions on HCC cells were attenuated by overexpression of miR253p but enhanced by its inhibitor. These data suggest that Sevo's antitumor effects on HCC could be explained, in part, by Sevo inhibiting the miR253p/PTEN/Akt/GSK3beta/betacatenin signaling pathway. +lncRNA target 32319536 hsa-mir-141 Fibrosis On the whole, the findings of the present study indicate that miR141 inhibition suppresses HSC activation via the AKT/mTOR pathway by targeting PTEN, highlighting that miR141 may serve as a novel therapeutic target for liver fibrosis. +circulation_biomarker_diagnosis_up 32319531 hsa-let-7d Pulmonary Arterial Hypertension The results obtained revealed that let7d was downregulated in the serum of PAH patients and rats with PAH. +circulation_biomarker_diagnosis_up 32319530 hsa-mir-1290 Pulmonary Fibrosis miR1290 was found to be upregulated in blood samples from patients with PF and in TGFbeta1stimulated A549 cells. +transcription factor target 32319512 hsa-mir-132 Bone Diseases These findings demonstrate that miR-132/212 promotes growth and inhibits apoptosis in PCSCs by regulating PTCH1-mediated Ihh/PTHrP pathway, suggesting that miR-132/212 cluster might serve as a novel target for bone diseases. +other 32319481 hsa-mir-10b Triple Negative Breast Neoplasms It has been acknowledged that miR-34a is downregulated and miR-10b is upregulated in TNBC, which promotes tumorigenesis and metastatic dissemination. +other 32319481 hsa-mir-34a Triple Negative Breast Neoplasms It has been acknowledged that miR-34a is downregulated and miR-10b is upregulated in TNBC, which promotes tumorigenesis and metastatic dissemination. +genetics_GWAS 32319382 hsa-mir-34a Leukemia, Myeloid, Acute MiR-34a high expression correlated with non FLT3-ITD mutation (P0.05) and lower-risk stage (P0.05) in elderly AML patients, miR-34b high expression correlated with normal karyotype (NK) (P0.05), CEBPA double mutation (P0.01), NPM1 mutation (P0.05), and WBC count C) and miRNA-499 rs3746444 (T > C) and asthma risk. CONCLUSIONS: The miR-499 rs3746444 (T > C) polymorphism is associated with asthma susceptibility and miRNA-146a rs2910164 (G > C) polymorphism has a protective role against susceptibility to asthma. +other 32307900 hsa-mir-26a Infertility CONCLUSION: miR-26a-5p has a potential to use as a diagnostic biomarker and provide new therapeutic approaches for male infertility. +circulation_biomarker_diagnosis_ns 32307887 hsa-mir-22 Alzheimer Disease RESULTS: In this study, we found that the expression level of miRNA-22 in peripheral blood was lower in AD patients than that in healthy population. +lncRNA target 32307830 hsa-mir-148a Breast Neoplasms Our study is the first to report that HOTTIP regulates the CSC-like properties of BCSCs by as a molecular sponge for miR-148a-3p to increase WNT1 expression, offering a new target for breast cancer therapy. +other 32307795 hsa-mir-16 Osteoarthritis Long non-coding RNA nuclear enriched abundant transcript 1 (NEAT1) and miR5p are up-regulated in OA tissues; however, their functions have not been clarified. +genetics_knock down_promote 32307765 hsa-mir-93 Breast Neoplasms Wiskott-Aldrich syndrome protein family member 3 (WASF3), a regulator of both cytoskeleton remodeling and CSC properties, was identified as a functional target of miR-93: overexpression of miR-93 reduced the protein level of WASF3 in breast cancer cells and WASF3 rescued the miR +other 32307200 hsa-mir-149 Uterine Cervical Neoplasms Besides, five key molecules miRNA5p, E2F4, KIF11, DTL, and SMC4 were suggested to play crucial roles in the development of HPV-positive CESC. +lncRNA target 32307083 hsa-mir-32 Triple Negative Breast Neoplasms Through rescue assays, we proved that WEE2-AS1/miR +other 32307002 hsa-mir-192 Gastrointestinal Neoplasms 5p in gastric cancer, it could be postulated to consider these miRNAs as promising diagnostic biomarkers. +lncRNA target 32306523 hsa-mir-129 Carcinoma, Non-Small-Cell Lung Components of the HMGB1-RSF1-IT2-miR5p-SNAI1 pathway may have a potential as prognostic and therapeutic targets in NSCLC. +other 32306499 hsa-mir-222 Liver Injury Using data from The Cancer Genome Atlas (TCGA), we showed that, in hepatocellular carcinoma (HCC), TIMP3 expression is associated with survival (P < .001), while miR-221 (P < .05), miR-222 (P < .01) and miR-181b (P < .01) are markers for a poor prognosis. +other 32306499 hsa-mir-181b Liver Injury Using data from The Cancer Genome Atlas (TCGA), we showed that, in hepatocellular carcinoma (HCC), TIMP3 expression is associated with survival (P < .001), while miR-221 (P < .05), miR-222 (P < .01) and miR-181b (P < .01) are markers for a poor prognosis. +other 32306499 hsa-mir-221 Liver Injury Using data from The Cancer Genome Atlas (TCGA), we showed that, in hepatocellular carcinoma (HCC), TIMP3 expression is associated with survival (P < .001), while miR-221 (P < .05), miR-222 (P < .01) and miR-181b (P < .01) are markers for a poor prognosis. +virus_miRNA 32306460 ebv-mir-BART6 Nasopharyngeal Carcinoma miR-BART6-3p inhibits cancer cell proliferation through the LOC553103-STMN1 axis +virus_miRNA 32306460 ebv-mir-BART6 stomach carcinoma miR-BART6-3p inhibits cancer cell proliferation through the LOC553103-STMN1 axis +lncRNA target 32306379 hsa-mir-23a Liver Cirrhosis CONCLUSION: We demonstrate mechanism pathway of miR-23a-5p on hepatic fibrosis and HSC activation, which may develop a therapeutic target for hepatic fibrosis. +transcription factor target 32306293 hsa-mir-4422 Alzheimer Disease It seems that the reduced expression of miR4422 that targets GSAP and BACE1 expression can lead to an increase in the formation of Abeta plaque. +lncRNA target 32306124 hsa-mir-21 Hypoxia-Ischemia, Brain Taken together, the key findings of the current study underlie the cerebral protective effect of miR-21 against HIBD in neonatal rats through the inhibition of CCL3. +lncRNA target 32305992 hsa-mir-107 Colorectal Neoplasms CONCLUSIONS ITGA5 circRNA may act as a sponge for miR-107 to upregulate FOXJ3 expression and act as a tumor suppressor in CRC cells. +lncRNA target 32305960 hsa-let-7f Osteosarcoma let-7f-5p and TARBP2 significantly inhibited the proliferation and invasion of OS cells. +other 32305959 hsa-mir-10b Breast Neoplasms Taken together, these findings suggest that LINC00324 plays a critical role in breast cancer progression by directly interacting with miR-10b-5p. +genetics_overexpression_promote 32305958 hsa-mir-548 Urinary Bladder Neoplasms Our results show that miR-548 downregulation or KIF2C overexpression restored BC cell proliferation, migration, and invasion following silencing of circRGNEF. +other 32305633 hsa-mir-136 Stomach Neoplasms Collectively, our data identified that the promotion of GC growth and metastasis induced by circRNA_100876 interacted with miR-136 and MIEN1, indicating an emerging announcement for uncovering the potential mechanism of GC progression. +other 32305357 hsa-mir-409 Tuberculosis 5p/mRNA interactions may provide some novel mechanisms for active TB. +genetics_overexpression_promote 32305057 hsa-mir-33a Melanoma Overexpression of miR-33a-5p repressed proliferation, migration, invasion, EMT and promoted apoptosis of melanoma cell in vitro, these effects were partially reversed by SNAI2 overexpression. +lncRNA target 32305055 hsa-mir-498 Esophageal Squamous Cell Carcinoma The expression of miR-498 was reduced in ESCC tissues while XBP1 expression was notably enhanced. TUG1 accelerated tumorigenesis and metastasis by inducing XBP1 expression through directly targeting miR-498 in ESCC. +genetics_overexpression_suppress 32305054 hsa-mir-193a Ovarian Neoplasms The overexpression of miR-193a-5p inhibited cell proliferation and induced apoptosis in human ovarian cancer. +lncRNA target 32305052 hsa-mir-143 Ovarian Neoplasms 3p target SMAD3, which eventually triggered the progression of OC. +other 32305038 hsa-mir-221 Obesity MicroRNA-221 (miR-221) is involved in the development of obesity and has been reported to negatively regulate insulin sensitivity. +transcription factor target 32304977 hsa-mir-23b Thyroid Neoplasms CONCLUSIONS: Upregulated expression of ANXA2 may promote the malignant biological behavior of THCA by affecting the involving pathways or being targeted by miR-23b-3p. +other 32304915 hsa-mir-222 Breast Neoplasms Such a hybrid sensing platform is capable of simultaneous detection of breast cancer related microRNA-221 (miRNA-221) and miRNA-222 in a specific and synchronous manner, without observable cross-reactions, as supported by experimental evidences. +other 32304915 hsa-mir-221 Breast Neoplasms Such a hybrid sensing platform is capable of simultaneous detection of breast cancer related microRNA-221 (miRNA-221) and miRNA-222 in a specific and synchronous manner, without observable cross-reactions, as supported by experimental evidences. +genetics_knock down_promote 32304779 hsa-mir-34a Colorectal Neoplasms CONCLUSIONS: The reciprocal inhibition between miR-34a and CSF1R and its loss in tumor cells may be relevant for therapeutic and prognostic approaches towards CRC management. +lncRNA target 32304765 hsa-mir-374a Hypoxia-Ischemia, Brain, Newborn SIGNIFICANCE: Our study recognized that miR-374a-5p as a novel regulator of microglial activation in neonatal HIE highlighted potential therapeutic target for the treatment of neonatal hypoxic-ischemic brain injury. +genetics_knock down_promote 32304760 hsa-mir-381 Prostatic Neoplasms Overexpressed miR-381 suppressed PCa cell proliferation while promoted autophagy and apoptosis of PCa cells. +circulation_biomarker_diagnosis_ns 32304754 hsa-mir-125b Polycystic Ovary Syndrome CONCLUSION: High serum LH concentrations in PCOS patients repress miR-125b-5p expression, which further increases Pak3 expression, leading to activation of ERK1/2 signalling, thus stimulating the expression of androgen synthesis-related enzymes and testosterone secretion in HA-PCOS. +exosome 32304669 hsa-mir-124 high grade glioma By insertion of brain-specific microRNA-124 (miR124) response elements into the viral genome, we improved the tumor specificity of EV-A71 oncolytic therapy by reducing its neurotoxicity while maintaining its replication potential and oncolytic capacity in gliomas. +genetics_GWAS 32304626 hsa-mir-181 Ventricular Remodeling Genetic miR-181 knockout in murine MI model led to deteriorated cardiac function, cardiac remodelling, and activation of Aldo-MR pathway while AAV9-mediated miR-181a overexpression improved cardiac function and deactivated Aldo-MR pathway proving a cardio-protective role of miR-181a. Thus, miR-181a's involvement in Aldo-MR-mediated cardiac remodelling confers it with tremendous potential to be developed further as a new therapeutic target. +genetics_GWAS 32304626 hsa-mir-181a Myocardial Infarction Genetic miR-181 knockout in murine MI model led to deteriorated cardiac function, cardiac remodelling, and activation of Aldo-MR pathway while AAV9-mediated miR-181a overexpression improved cardiac function and deactivated Aldo-MR pathway proving a cardio-protective role of miR-181a. Our in vivo studies further confirmed miR-181a as cardio-protective under MI stress. +genetics_GWAS 32304626 hsa-mir-181a Ventricular Remodeling Genetic miR-181 knockout in murine MI model led to deteriorated cardiac function, cardiac remodelling, and activation of Aldo-MR pathway while AAV9-mediated miR-181a overexpression improved cardiac function and deactivated Aldo-MR pathway proving a cardio-protective role of miR-181a. Thus, miR-181a's involvement in Aldo-MR-mediated cardiac remodelling confers it with tremendous potential to be developed further as a new therapeutic target. +genetics_GWAS 32304626 hsa-mir-181 Myocardial Infarction Genetic miR-181 knockout in murine MI model led to deteriorated cardiac function, cardiac remodelling, and activation of Aldo-MR pathway while AAV9-mediated miR-181a overexpression improved cardiac function and deactivated Aldo-MR pathway proving a cardio-protective role of miR-181a. Our in vivo studies further confirmed miR-181a as cardio-protective under MI stress. +transcription factor target 32304408 hsa-mir-103 Carcinoma, Non-Small-Cell Lung These results demonstrate that salidroside suppresses NSCLC proliferation and metastasis by regulating miR +lncRNA target 32303947 hsa-mir-205 Periodontitis gingivalis could inhibit miR +lncRNA target 32303890 hsa-mir-455 Uterine Cervical Neoplasms S1PR1 recovered the inhibition of cell viability and metastasis induced by miR +lncRNA target 32303750 hsa-mir-146a Thyroid Cancer, Papillary HIF1alpha increased miR-146a expression to promote PTC progression in vitro, which was achieved by inhibiting GABPA, a target gene of miR-146a. +genetics_overexpression_promote 32303680 hsa-mir-590 Stomach Neoplasms Immunoblot and immunofluorescence analyses confirmed that the overexpression of miR-590 can inhibit the EMT in gastric cancer cells. +other 32303246 hsa-let-7c Urinary Bladder Neoplasms Supporting these findings, in vitro comparison of extra-/intra-cellular ratios of cluster levels between BC cells, showed a higher ratio for let-7c in HG-NMIBC versus low-grade cells. +transcription factor target 32303004 hsa-mir-223 Insulin Resistance These findings showed that uc.333 improves IR by binding to miR-223; thus, uc.333 may be a useful target for the treatment and prevention of IR. +other 32302972 hsa-mir-297b Diabetes Mellitus, Type 2 We found that miR-297b-5p and miR-374c-5p were involved in stearic-acid-induced lipotoxicity to beta-TC-6 cells. +other 32302972 hsa-mir-374c Diabetes Mellitus, Type 2 We found that miR-297b-5p and miR-374c-5p were involved in stearic-acid-induced lipotoxicity to beta-TC-6 cells. +genetics_overexpression_promote 32302969 hsa-mir-146b Thyroid Cancer, Papillary miR-146b-5p is overexpressed in papillary thyroid carcinoma (PTC) and is thought to be a related diagnostic marker. +genetics_knock down_promote 32302508 hsa-mir-503 Squamous Cell Carcinoma of Head and Neck Gain of hsa_circ_0072387 or knockdown of miR +lncRNA target 32302291 hsa-mir-22 Osteosarcoma Finally, miR-142 directly targets ULK1, ATG4A, and ATG5, while miR-22 directly targets ULK1 to inhibit the expression of the target gene; The Sox2OT-V7/miR-142/miR-22 axis modulates autophagy in OS cells by regulating ULK1, ATG4A, and ATG5. +lncRNA target 32302291 hsa-mir-142 Osteosarcoma Finally, miR-142 directly targets ULK1, ATG4A, and ATG5, while miR-22 directly targets ULK1 to inhibit the expression of the target gene; The Sox2OT-V7/miR-142/miR-22 axis modulates autophagy in OS cells by regulating ULK1, ATG4A, and ATG5. +lncRNA target 32302289 hsa-mir-124 Inflammation But in OA these miRs are inhibited, especially miR3p which regulates not only NF-kappaB but also TNF-alpha, IL-6 and MMP7. +lncRNA target 32302289 hsa-mir-124 Osteoarthritis But in OA these miRs are inhibited, especially miR3p which regulates not only NF-kappaB but also TNF-alpha, IL-6 and MMP7. +lncRNA target 32301392 hsa-mir-203a Pancreatic Carcinoma The upregulation of miR-203a-3p expression inhibited the proliferation, migration, and invasion ability of pancreatic cancer cells by suppressing the epithelial-mesenchymal transition process via sponging SLUG. +circulation_biomarker_diagnosis_up 32301334 hsa-mir-9 Alzheimer Disease Compared to patients without dementia, a median 3-fold decrease in miR-9 levels was found among patients with AD (P = .001). Our findings support blood-borne miR-9 as a candidate biomarker for probable AD, embodied by evidence from the literature of its implication in amyloidogenesis. +transcription factor target 32301290 hsa-mir-874 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: In conclusion, miR-874 inhibited proliferation and mobility by regulating AQP3 in NSCLC. +lncRNA target 32301289 hsa-mir-21 Atherosclerosis inhibited DDAH1-ADMA-eNOS-NO pathway promotes the pathogenesis of atherosclerosis which can be rescued by DMY. +exosome 32301277 hsa-mir-122 Pancreatic Carcinoma Collectively, our study reveals that constrained lncRNA SBF2-AS1 in M2 macrophage-derived exosomes increases miR +other 32301252 hsa-mir-423 Carcinoma, Hepatocellular 3p, miR-let-7d-5p). +other 32301252 hsa-mir-142 Hepatitis B 3p, miR-let-7d-5p). +other 32301252 hsa-let-7d Hepatitis B 3p, miR-let-7d-5p). +other 32301252 hsa-mir-142 Carcinoma, Hepatocellular 3p, miR-let-7d-5p). +other 32301252 hsa-let-7d Carcinoma, Hepatocellular 3p, miR-let-7d-5p). +other 32301252 hsa-mir-423 Hepatitis B 3p, miR-let-7d-5p). +other 32301252 hsa-mir-199a Carcinoma, Hepatocellular 3p, miR-let-7d-5p). +other 32301252 hsa-mir-199a Hepatitis B 3p, miR-let-7d-5p). +other 32301252 hsa-mir-141 Carcinoma, Hepatocellular Several miRNAs (miR3p, let-7d-5p) that correlated with regression have previously been implicated in the pathophysiology of non-alcoholic steatohepatitis. +other 32301252 hsa-mir-141 Hepatitis B Several miRNAs (miR3p, let-7d-5p) that correlated with regression have previously been implicated in the pathophysiology of non-alcoholic steatohepatitis. +circulation_biomarker_diagnosis_ns 32301163 hsa-mir-195 Diabetes, Gestational 5p expression was significantly increased in serum samples from GDM patients as compared with that in healthy pregnancies. +other 32300359 hsa-mir-29b Idiopathic Pulmonary Fibrosis Six genes (COL3A1, COL1A2, OGN, COL15A1, ASPN, and MXRA5) and three miRNAs (hsa-miR-29c-3p, hsa-let-7c-5p, and hsa-miR-29b-3p) were related to the survival time of lung adenocarcinoma (LUAD). +other 32300359 hsa-mir-29c Idiopathic Pulmonary Fibrosis Six genes (COL3A1, COL1A2, OGN, COL15A1, ASPN, and MXRA5) and three miRNAs (hsa-miR-29c-3p, hsa-let-7c-5p, and hsa-miR-29b-3p) were related to the survival time of lung adenocarcinoma (LUAD). +other 32300359 hsa-let-7c Idiopathic Pulmonary Fibrosis Six genes (COL3A1, COL1A2, OGN, COL15A1, ASPN, and MXRA5) and three miRNAs (hsa-miR-29c-3p, hsa-let-7c-5p, and hsa-miR-29b-3p) were related to the survival time of lung adenocarcinoma (LUAD). +other 32300359 hsa-let-7c Carcinoma, Non-Small-Cell Lung Six genes (COL3A1, COL1A2, OGN, COL15A1, ASPN, and MXRA5) and three miRNAs (hsa-miR-29c-3p, hsa-let-7c-5p, and hsa-miR-29b-3p) were related to the survival time of lung adenocarcinoma (LUAD). +other 32300359 hsa-mir-29b Carcinoma, Non-Small-Cell Lung Six genes (COL3A1, COL1A2, OGN, COL15A1, ASPN, and MXRA5) and three miRNAs (hsa-miR-29c-3p, hsa-let-7c-5p, and hsa-miR-29b-3p) were related to the survival time of lung adenocarcinoma (LUAD). +other 32300359 hsa-mir-29c Carcinoma, Non-Small-Cell Lung Six genes (COL3A1, COL1A2, OGN, COL15A1, ASPN, and MXRA5) and three miRNAs (hsa-miR-29c-3p, hsa-let-7c-5p, and hsa-miR-29b-3p) were related to the survival time of lung adenocarcinoma (LUAD). +lncRNA target 32300102 hsa-mir-619 Stomach Neoplasms 5p/AMPK/PGC1alpha/CEBPB axis to promote stemness and chemo-resistance of GC, indicating that targeting HCP5 was a novel approach to enhancing the efficacy of chemotherapy in GC. +lncRNA target 32299591 hsa-mir-21 Cardiomyopathies OBJECTIVES: The aims of this study were to test the applicability and therapeutic efficacy of local, catheter-based delivery of antimiR-21 in a pig model of heart failure and determine its effect on the cardiac transcriptomic signature and cellular composition. CONCLUSIONS: This study provides the first evidence for the feasibility and therapeutic efficacy of miR-21 inhibition in a large animal model of heart failure. +lncRNA target 32299591 hsa-mir-21 Reperfusion Injury OBJECTIVES: The aims of this study were to test the applicability and therapeutic efficacy of local, catheter-based delivery of antimiR-21 in a pig model of heart failure and determine its effect on the cardiac transcriptomic signature and cellular composition. CONCLUSIONS: This study provides the first evidence for the feasibility and therapeutic efficacy of miR-21 inhibition in a large animal model of heart failure. +genetics_GWAS 32299427 hsa-mir-100 Endometriosis 5p may thus contribute to understand the epigenetic mechanisms involved in the pathogenesis of endometriosis. +lncRNA target 32299427 hsa-mir-100 Bowen-Conradi syndrome 5p transfection enhanced the motility of NESCs by inhibiting SMARCD1 expression and MMP1 activation. +other 32299382 hsa-mir-135a Carcinoma, Non-Small-Cell Lung 5p and hsa-miR-135a-5p) and genes (BIRC5, FGF2, RTKN2 and SLIT3) may play important roles in the pathogenesis of NSCLC. +other 32299382 hsa-mir-196a Carcinoma, Non-Small-Cell Lung 5p and hsa-miR-135a-5p) and genes (BIRC5, FGF2, RTKN2 and SLIT3) may play important roles in the pathogenesis of NSCLC. +other 32299382 hsa-mir-1 Carcinoma, Non-Small-Cell Lung 5p and hsa-miR-135a-5p) and genes (BIRC5, FGF2, RTKN2 and SLIT3) may play important roles in the pathogenesis of NSCLC. +other 32299382 hsa-mir-9 Carcinoma, Non-Small-Cell Lung 5p and hsa-miR-135a-5p) and genes (BIRC5, FGF2, RTKN2 and SLIT3) may play important roles in the pathogenesis of NSCLC. +other 32299382 hsa-mir-218 Carcinoma, Non-Small-Cell Lung 5p and hsa-miR-135a-5p) and genes (BIRC5, FGF2, RTKN2 and SLIT3) may play important roles in the pathogenesis of NSCLC. +lncRNA target 32299271 hsa-mir-25 Endometriosis 3p directly targets Sp1. +lncRNA target 32299063 hsa-mir-1227 Carcinoma, Endometrioid MAPK13/ATF2 axis is a promising target for EC treatment. +circulation_biomarker_diagnosis_ns 32299022 hsa-mir-141 Nasopharyngeal Carcinoma 3p in nasopharyngeal carcinoma (NPC) via targeting neoplasm metastasis 1 (NME1). +genetics_overexpression_promote 32298609 hsa-mir-524 Breast Neoplasms In addition, overexpressed FSTL1 effectively abolished the effect of miR +transcription factor target 32298598 hsa-mir-518 Colorectal Neoplasms The inhibitory effects of miR +epigenetics 32298550 hsa-mir-339 Ovarian Neoplasms The aim of this work is to evaluate the clinical significance of methylation of 13 tumor-associated microRNA genes (MIR-124a-2, MIR-124a-3, MIR +epigenetics 32298550 hsa-mir-124a Ovarian Neoplasms The aim of this work is to evaluate the clinical significance of methylation of 13 tumor-associated microRNA genes (MIR-124a-2, MIR-124a-3, MIR +epigenetics 32298550 hsa-mir-34c Ovarian Neoplasms The aim of this work is to evaluate the clinical significance of methylation of 13 tumor-associated microRNA genes (MIR-124a-2, MIR-124a-3, MIR +epigenetics 32298550 hsa-mir-137 Ovarian Neoplasms The aim of this work is to evaluate the clinical significance of methylation of 13 tumor-associated microRNA genes (MIR-124a-2, MIR-124a-3, MIR +epigenetics 32298550 hsa-mir-125b-1 Ovarian Neoplasms The aim of this work is to evaluate the clinical significance of methylation of 13 tumor-associated microRNA genes (MIR-124a-2, MIR-124a-3, MIR +epigenetics 32298550 hsa-mir-129-2 Ovarian Neoplasms The aim of this work is to evaluate the clinical significance of methylation of 13 tumor-associated microRNA genes (MIR-124a-2, MIR-124a-3, MIR +epigenetics 32298550 hsa-mir-203a Ovarian Neoplasms The aim of this work is to evaluate the clinical significance of methylation of 13 tumor-associated microRNA genes (MIR-124a-2, MIR-124a-3, MIR +epigenetics 32298550 hsa-mir-375 Ovarian Neoplasms The aim of this work is to evaluate the clinical significance of methylation of 13 tumor-associated microRNA genes (MIR-124a-2, MIR-124a-3, MIR +epigenetics 32298550 hsa-mir-34b Ovarian Neoplasms The aim of this work is to evaluate the clinical significance of methylation of 13 tumor-associated microRNA genes (MIR-124a-2, MIR-124a-3, MIR +epigenetics 32298550 hsa-mir-9-1 Ovarian Neoplasms The aim of this work is to evaluate the clinical significance of methylation of 13 tumor-associated microRNA genes (MIR-124a-2, MIR-124a-3, MIR +epigenetics 32298550 hsa-mir-132 Ovarian Neoplasms The aim of this work is to evaluate the clinical significance of methylation of 13 tumor-associated microRNA genes (MIR-124a-2, MIR-124a-3, MIR +epigenetics 32298550 hsa-mir-9 Ovarian Neoplasms The aim of this work is to evaluate the clinical significance of methylation of 13 tumor-associated microRNA genes (MIR-124a-2, MIR-124a-3, MIR +epigenetics 32298550 hsa-mir-127 Ovarian Neoplasms The aim of this work is to evaluate the clinical significance of methylation of 13 tumor-associated microRNA genes (MIR-124a-2, MIR-124a-3, MIR +epigenetics 32298550 hsa-mir-124a-2 Ovarian Neoplasms The aim of this work is to evaluate the clinical significance of methylation of 13 tumor-associated microRNA genes (MIR-124a-2, MIR-124a-3, MIR +lncRNA target 32298082 hsa-mir-194 Esophageal Squamous Cell Carcinoma gingivalis might promote ESCC proliferation and migration via the miR-194/GRHL3/PTEN/Akt signaling axis. +lncRNA target 32297697 hsa-mir-450b Carcinoma, Non-Small-Cell Lung CONCLUSIONS: H3K27ac-activated LINC00519 acts as a competing endogenous RNA (ceRNA) to promote LUSC progression by targeting miR-450b-5p/miR +lncRNA target 32297697 hsa-mir-515 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: H3K27ac-activated LINC00519 acts as a competing endogenous RNA (ceRNA) to promote LUSC progression by targeting miR-450b-5p/miR +other 32297687 hsa-mir-20a Liver Injury We further show that miRNA-20a, -23a, -150, -200b, -503, and -663 undergo concordant changes in expression in 3 distinct clinical settings: liver regeneration accompanying successful ALT, clinical recovery after ALF, and clinical recompensation after cure of HCV. +target gene 32297644 hsa-mir-92a Spinal Cord Injuries MicroRNA-92a-3p enhances functional recovery and suppresses apoptosis after spinal cord injury via targeting phosphatase and tensin homolog. +genetics_overexpression_promote 32297639 hsa-mir-152 Precursor Cell Lymphoblastic Leukemia-Lymphoma Moreover, functional assays pointed out that LINC00221 overexpression posed anti-proliferation and pro-apoptosis effects in ALL cells, and these effects could be separately reversed by miR +other 32297569 hsa-mir-29a Cardiomegaly Therefore, NPY leads to down-regulation of miR-29a-3p expression, up-regulation of Drp1 expression, and NPY leads to CH. +other 32297422 hsa-mir-153 Endocrine System Diseases Correlation analyses revealed neural expression of miR-153 and miR-181a was associated with socio-communication deficits in LD BPA individuals. +other 32297422 hsa-mir-181a Endocrine System Diseases Correlation analyses revealed neural expression of miR-153 and miR-181a was associated with socio-communication deficits in LD BPA individuals. +genetics_overexpression_promote 32297303 hsa-mir-145 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: From our data we conclude that circBIRC6 overexpression promotes NSCLC cell progression, possibly by sponging miR-145. +other 32297149 hsa-mir-196a Angelman Syndrome SNHG1/miR-196a/MAPK6 axis may be of therapeutic significance in AS. +other 32297103 hsa-mir-381 Ischemic Stroke 3p downregulates Map3k8 and Cebpb to protect against ischemic stroke, broadening our understanding of the pathogenesis of ischemic stroke. +lncRNA target 32296644 hsa-mir-155 Neuralgia Our current study was to determine the inhibitory effects of blocking microRNA-155 (miR-155) signal on BTZ-induced neuropathic pain and the underlying mechanisms. Overall, we show the key role of miR-155 in modifying BTZ-induced neuropathic pain through TNFR1-TRPA1 pathway, suggesting that miR-155 is a potential target in preventing neuropathic pain development during intervention of BTZ. +lncRNA target 32296579 hsa-mir-6744 Breast Neoplasms 5p, in regulating anoikis in breast cancer and identify its target gene. +lncRNA target 32296392 hsa-mir-29b Diabetes, Gestational These results imply that down-regulation of miR-29b may be related with the development of GDM partially via increasing the expression of HIF3A, which may provide a new insight for the mechanism of GDM. +genetics_overexpression_suppress 32296334 hsa-mir-374a Triple Negative Breast Neoplasms MiR-374a is overexpressed in TNBC cells and has oncogenic properties. +circulation_biomarker_diagnosis_ns 32296037 hsa-mir-33a Dyslipidemias Clinically, the incidence of dyslipidemia in liver transplant recipients with elevated serum miR-33a after liver transplantation was higher than that in patients without elevated serum miR-33a (46.3% vs. MiR-33a is likely a risk factor for tacrolimus-related dyslipidemia, providing a potential therapeutic target to combat tacrolimus-induced dyslipidemia after liver transplantation. +other 32295264 hsa-mir-106b Fatty Liver 5p showed higher performances in discriminating different grades of steatosis in PWS (AUC = 0.84, sens/spec 93/74%). +other 32295264 hsa-mir-151a Prader-Willi Syndrome 5p showed higher performances in discriminating different grades of steatosis in PWS (AUC = 0.84, sens/spec 93/74%). +other 32295264 hsa-mir-151a Fatty Liver 5p showed higher performances in discriminating different grades of steatosis in PWS (AUC = 0.84, sens/spec 93/74%). +other 32295264 hsa-mir-93 Prader-Willi Syndrome 5p showed higher performances in discriminating different grades of steatosis in PWS (AUC = 0.84, sens/spec 93/74%). +other 32295264 hsa-mir-106b Prader-Willi Syndrome 5p showed higher performances in discriminating different grades of steatosis in PWS (AUC = 0.84, sens/spec 93/74%). +other 32295264 hsa-mir-93 Fatty Liver 5p showed higher performances in discriminating different grades of steatosis in PWS (AUC = 0.84, sens/spec 93/74%). +other 32295105 hsa-mir-21 Atrial Fibrillation Our findings indicate that miR-21 and NT-proBNP correlate with echocardiographic parameters of atrial remodeling and predict AF, in particular if combined. +lncRNA target 32294702 hsa-mir-216a Diabetic Nephropathies ZEB1-AS1 and BMP7 were down-regulated, while miR-216a-5p was highly expressed in kidney tissues of DN patients. lncRNA ZEB1-AS1 inhibited high glucose-induced EMT and fibrogenesis via regulating miR-216a-5p/BMP7 axis in diabetic nephropathy, providing a potential target for DN therapy. +transcription factor target 32294623 hsa-mir-1248 Diabetes Mellitus The expression of miRNA-1248 was decreased in the hADSCs of DM patients and hence failed to positively regulate stem cell activity, differentiation functions, and angiogenesis promotion effect. MiRNA-1248 may have potential to be used as a novel therapeutic target for wound healing in DM patients or restoring the wound healing ability of diabetic hADSCs. +other 32294553 hsa-mir-1 Infarction We found that PFBT@miRTat NP-treated MSCs significantly restored the infarcted myocardium by promoting stem cell cardiac differentiation and integration with the in situ cardiac tissues. +genetics_overexpression_promote 32294474 hsa-mir-186 Osteochondritis Dissecans SIRT6 overexpression reversed the inhibitory effect of miR-186 on the OD of rBMSCs. +transcription factor target 32294039 hsa-mir-485 Brain Ischemia 5p protected cells following I/R injury via targeting Rac1/Notch2 signaling suggest that targeted upregulation of miR +lncRNA target 32293663 hsa-mir-139 Diabetes Mellitus 5p inhibitor DAPT group. +genetics_knock down_promote 32293550 hsa-mir-490 Stomach Neoplasms CONCLUSION: Knockdown of LINC00483 inhibited gastric cancer development in vitro and in vivo by increasing miR +genetics_knock down_promote 32293498 hsa-mir-543 Arthritis, Rheumatoid CONCLUSION: The key findings support that PVT1 knockdown has the potency to hinder RA progression by inhibiting SCUBE2 expression to sponge miR-543. +exosome 32293494 hsa-mir-93 Colorectal Neoplasms 5p as a specific exosomal cargo that rescues CRC cells against radiation-induced apoptosis. +lncRNA target 32293484 hsa-mir-505 Osteoporosis CONCLUSION: This study is the first to report miR-505 could bind to the RUNX2 gene and thus regulate partly the dysfunction of osteoblasts differentiation, which is expected to be targets for the treatment of osteoporosis. +lncRNA target 32293332 hsa-mir-181d Colonic Neoplasms miR-29a (in left); miR-155, miR181-d, miR-576 and miR23a (in right)) appear to exhibit side-specificity in control of their target transcripts and is pronounced in right colon tumors. +lncRNA target 32293332 hsa-mir-576 Colonic Neoplasms miR-29a (in left); miR-155, miR181-d, miR-576 and miR23a (in right)) appear to exhibit side-specificity in control of their target transcripts and is pronounced in right colon tumors. +lncRNA target 32293332 hsa-mir-23a Colonic Neoplasms miR-29a (in left); miR-155, miR181-d, miR-576 and miR23a (in right)) appear to exhibit side-specificity in control of their target transcripts and is pronounced in right colon tumors. +lncRNA target 32293332 hsa-mir-29a Colonic Neoplasms miR-29a (in left); miR-155, miR181-d, miR-576 and miR23a (in right)) appear to exhibit side-specificity in control of their target transcripts and is pronounced in right colon tumors. +lncRNA target 32293332 hsa-mir-155 Colonic Neoplasms miR-29a (in left); miR-155, miR181-d, miR-576 and miR23a (in right)) appear to exhibit side-specificity in control of their target transcripts and is pronounced in right colon tumors. +circulation_biomarker_prognosis_up 32293319 hsa-mir-4516 Colorectal Neoplasms 5p in serum of patients with colorectal cancer. +circulation_biomarker_prognosis_up 32293319 hsa-mir-21 Colorectal Neoplasms 5p in serum of patients with colorectal cancer. +lncRNA target 32292999 hsa-mir-155 Asthma demonstrates heightened MALAT1 expression in asthma and further shows that this lncRNA targets miR-155 to promote Th2 differentiation in this disease. +transcription factor target 32292821 hsa-mir-186 Sepsis CONCLUSION: miRNA-186 over-expression has effects that improve renal injury induced by sepsis via PTEN pathway. +lncRNA target 32292498 hsa-mir-128 Osteoporosis Conclusions: Our findings reveal a critical mechanism for osteoclastogenesis that is mediated by the miR-128/SIRT1/NF-kappaB signaling axis, highlighting a possible avenue for the further exploration of diagnostic and therapeutic target molecules in PMOP. +lncRNA target 32292498 hsa-mir-128 Osteoporosis, Postmenopausal Conclusions: Our findings reveal a critical mechanism for osteoclastogenesis that is mediated by the miR-128/SIRT1/NF-kappaB signaling axis, highlighting a possible avenue for the further exploration of diagnostic and therapeutic target molecules in PMOP. +lncRNA target 32292108 hsa-mir-146a Spinal Cord Injuries Aims: We investigated whether miRNA (miR) 146a-5p-loaded nanoparticles (NPs) can attenuate neuropathic pain behaviors in the rat spinal nerve ligation-induced neuropathic pain model by inhibiting activation of the NF-kappaB and p38 MAPK pathways in spinal microglia. +lncRNA target 32292108 hsa-mir-146a Neuralgia Aims: We investigated whether miRNA (miR) 146a-5p-loaded nanoparticles (NPs) can attenuate neuropathic pain behaviors in the rat spinal nerve ligation-induced neuropathic pain model by inhibiting activation of the NF-kappaB and p38 MAPK pathways in spinal microglia. Conclusion: The anti-inflammatory effects of miR 146a-5p along with nanoparticle-based materials make miR NPs promising tools for treating neuropathic pain. +transcription factor target 32291953 hsa-mir-125b Breast Neoplasms CONCLUSIONS: miRNA-125b mimic inhibited proliferation, migration, and invasion of breast cancer cells through targeting MMP11 protein. +other 32291905 hsa-mir-181a Aicardi-Goutieres syndrome 5 Downregulation of miR-181a with age was associated with an accumulation of autophagy-related proteins and abnormal mitochondria. +lncRNA target 32291635 hsa-mir-10a Friedreich Ataxia We observed a significant decrease in the levels of miRNA-10a-5p and increase in the levels of BDNF upon correction of FRDA cells via zinc-finger nuclease (ZFN)-mediated excision of expanded GAA repeats. +transcription factor target 32291604 hsa-mir-703 Necrobiotic Disorders More importantly, miR-703 protects against H/R-induced cardiomyocyte injury via inhibiting the NLRP3/caspase +genetics_GWAS 32291425 hsa-mir-21 Carcinoma, Hepatocellular CONCLUSION: Micro-RNA-21 rs1292037 A greater than G polymorphism can predict IRI and tumor progression by regulating the miR-21/IL-12A.axis. +genetics_GWAS 32291425 hsa-mir-21 Reperfusion Injury CONCLUSION: Micro-RNA-21 rs1292037 A greater than G polymorphism can predict IRI and tumor progression by regulating the miR-21/IL-12A.axis. +circulation_biomarker_diagnosis_ns 32290852 hsa-mir-126 Diabetes Mellitus, Type 2 Thus, we will aim to assess the effects of synbiotics on microbiota, serum level of tumor necrosis factor-alpha (TNF-alpha), and expression of microRNA-126 and microRNA-146a in patients with T2DM. +circulation_biomarker_diagnosis_ns 32290852 hsa-mir-146a Diabetes Mellitus, Type 2 Thus, we will aim to assess the effects of synbiotics on microbiota, serum level of tumor necrosis factor-alpha (TNF-alpha), and expression of microRNA-126 and microRNA-146a in patients with T2DM. +other 32290826 hsa-mir-136 Diabetic Retinopathy CONCLUSIONS: In brief, HIF1A, PGF, KIF11, G protein subunits, and miR-136, miR-374 may all be involved in angiogenesis, retinal endothelial cell proliferation, and visual signal transduction in proliferative DR. +other 32289629 hsa-mir-122 Hepatitis B, Chronic These present findings presented that the complex and context-specific associations of miR-122 with liver diseases, suggesting that this may be a promising marker for liver injury. +genetics_overexpression_promote 32289378 hsa-mir-30 Squamous Cell Carcinoma of Head and Neck In addition, Tra2beta overexpression markedly abrogated the tumor suppressive role of miR +other 32289298 hsa-mir-26a Aortic Aneurysm, Thoracic For bicuspid patients, aortic wall strain was associated with miR-26a (R = 0.55, P = .041) and miR-320a (R = 0.69, P < .001), which shows a significant difference between bicuspid and tricuspid patients. +other 32289298 hsa-mir-20a Aortic Aneurysm, Thoracic For bicuspid patients, aortic wall strain was associated with miR-26a (R = 0.55, P = .041) and miR-320a (R = 0.69, P < .001), which shows a significant difference between bicuspid and tricuspid patients. +other 32286677 hsa-mir-20b Prostatic Neoplasms CONCLUSION: The present study demonstrated that tissue miR-20b expression level could be a promising biomarker of prognosis in prostate cancer. +genetics_knock down_suppress 32286143 hsa-mir-296 Leukemia, Myeloid, Acute Moreover, UCA1 knockdown inhibited AML cell tumorigenesis in vivo, which was associated with regulation of miR +genetics_overexpression_promote 32286127 hsa-mir-206 Liver Neoplasms Special EGFR inhibitor Gefitinib abolished the discrepancy in liver CSC proportion and the self-renewal capacity between miR-206 overexpression hepatoma cells and control cells, which further confirmed that EGFR was required in miR +lncRNA target 32285917 hsa-mir-139 Carcinoma, Hepatocellular 5p/SLITRK4 pathway in HCC growth and progression and may provide new targets for us to better arrange the progression of HCC. +transcription factor target 32285757 hsa-mir-34a Multiple Myeloma The observed strong positive association between high body burdens of TCDD and miR-34a, a tumor suppressor regulated by p53, in this MGUS population warrants clarification of the TCDD-miR-34a relationship and its role in the pathogenesis of MGUS and risk for MM. +circulation_biomarker_diagnosis_ns 32285355 hsa-mir-503 Ischemic Stroke Results showed that plasma miR-503 was significantly increased in IS patients, especially in acute period and severe cases and subtypes of LAA and TACI, and was positively correlated with vWF. +other 32285112 hsa-mir-145a Sepsis CONCLUSION: Our results demonstrated that pericyte miR-145a mediates sepsis-associated microvascular dysfunction, potentially by means of Flimediated modulation of NF-kappaB signaling. +other 32285112 hsa-mir-145a Nerve Degeneration CONCLUSION: Our results demonstrated that pericyte miR-145a mediates sepsis-associated microvascular dysfunction, potentially by means of Flimediated modulation of NF-kappaB signaling. +exosome 32284792 hsa-mir-155 Squamous Cell Carcinoma of Head and Neck In the present study, we document for the first time the critical role of exosomes in mediating increments in miR-155 expression in OSCC cells that have acquired cisplatin resistance (cis(Res) cells). +lncRNA target 32284739 hsa-mir-194 Ovarian Neoplasms We further found that IGF1R and PPFIBP are targets of miR +genetics_knock down_promote 32284738 hsa-mir-425 Urinary Bladder Neoplasms Methods: The expression of miR-425 and Dickkopf 3 (DKK3) was examined in clinical BC specimens. +transcription factor target 32284700 hsa-mir-429 Brain Injuries CONCLUSION: We concluded that miR-429 exerts protective effects against OGD/R-induce injury in vitro through modulation of Cxcl1 and nuclear factor kinase B pathway, hoping provide a new view on the pathogenesis of cerebral I/R injury and a feasible potential therapeutic target. +genetics_knock down_promote 32284251 hsa-mir-574 Thyroid Neoplasms Biological function experiments showed that knockdown of miR +transcription factor target 32284171 hsa-mir-23b Mesothelioma, Malignant These results revealed that miR-23b contributes to HEG1-dependent cell proliferation through evasion of cytotoxicity induced by apoptosis and autophagy in MM cells. HEG1-dependent/mediated miR-23b signaling may therefore be a potential target for MM diagnosis and therapy. +genetics_knock down_promote 32284070 hsa-mir-489 Stomach Neoplasms Knockdown of HDAC7 exerted inhibited effect on GC progression and it markedly overturned miR-489 inhibitor-medicated effect on GC cells. +circulation_biomarker_diagnosis_ns 32283952 hsa-mir-199a Infertility In conclusion, circulating miR-199a-3p and miR +circulation_biomarker_diagnosis_ns 32283952 hsa-mir-21 Infertility In conclusion, circulating miR-199a-3p and miR +lncRNA target 32283909 hsa-mir-25 Osteosarcoma This study aimed to investigate the effect of baicalein and miR-25 on Wnt/beta-catenin signaling pathway of osteosarcoma cell line Saos-2. CONCLUSION: These findings demonstrate that baicalein may target genes related to the Wnt/beta-catenin pathway by regulating miR-25 expression and may be a potential Wnt/beta-catenin pathway inhibitor for osteosarcoma therapy. +genetics_GWAS 32283582 hsa-mir-222 Carcinoma, Non-Small-Cell Lung There was a significant correlation between the high miR-222 as a poor prognosis in advanced stage NSCLC with M1b metastasis (Median Survival/MS: 27 d, P=0.049) and positive EGFR mutations (MS: 74 d, P=0.049) and correlation of miR-155 with adenocarcinoma (MS: 69 d, P=0.034) and positive EGFR gene mutations (MS: 58 d, P=0.023). High expression of miR-155 and miR-222 are poor prognoses, especially high miR-222 found in metastasis M1b and positive EGFR mutation and miR-155 found in adenocarcinoma and positive EGFR gene mutations. +genetics_GWAS 32283582 hsa-mir-155 Carcinoma, Non-Small-Cell Lung There was a significant correlation between the high miR-222 as a poor prognosis in advanced stage NSCLC with M1b metastasis (Median Survival/MS: 27 d, P=0.049) and positive EGFR mutations (MS: 74 d, P=0.049) and correlation of miR-155 with adenocarcinoma (MS: 69 d, P=0.034) and positive EGFR gene mutations (MS: 58 d, P=0.023). High expression of miR-155 and miR-222 are poor prognoses, especially high miR-222 found in metastasis M1b and positive EGFR mutation and miR-155 found in adenocarcinoma and positive EGFR gene mutations. +transcription factor target 32283571 hsa-mir-139 Adenocarcinoma of Lung Mechanistically, CASC5 promoted LUAD proliferation by targeting miR +genetics_knock down_promote 32283566 hsa-mir-653 Uterine Cervical Neoplasms 5p downregulation reversed the suppressive function of DGUOK-AS1 knockdown on cell growth and DNA repair in CC. +lncRNA target 32283545 hsa-mir-10a Osteoarthritis Moreover, we found that HOXA3 acted as the targeted genes of miR-10a-5p and miR-10a-5p contributed to the progression of OA by suppressing HOXA3 expression. +lncRNA target 32283508 hsa-mir-182 spondyloepimetaphyseal dysplasia, Strudwick type 5p-mediated inhibitory effect on TNF-alpha-induced ASM cell proliferation and migration. +other 32283508 hsa-mir-182 Asthma 5p/TRIM8/NF-kappaB axis in the airway remodeling of asthma. +genetics_overexpression_promote 32282768 hsa-mir-375 Inflammation Overexpression of miR-375 promoted inflammation and the apoptosis of acinar cells through inhibiting autophagy. +lncRNA target 32282768 hsa-mir-375 Dementia, Vascular OBJECTIVES: MicroRNAs have been considered to be closely related with the development of severe acute pancreatitis (SAP), and microRNA-375 (miR-375) was believed to be a marker of SAP. This study first proves that miR-375 modulates the development of SAP through targeting ATG7. +other 32282768 hsa-mir-375 Pancreatitis, Acute Necrotizing OBJECTIVES: MicroRNAs have been considered to be closely related with the development of severe acute pancreatitis (SAP), and microRNA-375 (miR-375) was believed to be a marker of SAP. +other 32282768 hsa-mir-375 Pancreatitis OBJECTIVES: MicroRNAs have been considered to be closely related with the development of severe acute pancreatitis (SAP), and microRNA-375 (miR-375) was believed to be a marker of SAP. RESULTS: The level of miR-375 in pancreatitis tissues and cell lines was upregulated. +genetics_knock down_suppress 32282501 hsa-mir-17 Stanford Type A Aortic Dissection Quantitative real-time PCR (qRT-PCR) was performed to detect the expression of XIST and miR-17 in the aortic wall tissues of TAAD patients and age-matched healthy volunteers. In conclusion, knockdown of lncRNA XIST might attenuate the progression of TAAD by sponging miR-17 and regulating the following downstream PTEN, which suggested a novel therapeutic target for TAAD treatment. +lncRNA target 32282367 hsa-mir-203a Colorectal Neoplasms Taken together, our data indicate that miR-203a inhibits colon cancer cell proliferation by targeting RNF6, offer novel insights into the regulatory network of miR-203a-modulated cell cycle and proliferation, and suggest that miR-203a a potential therapeutic target in CRC treatment. +other 32282121 hsa-mir-141 Aortic Valve Insufficiency We demonstrated that miR3p was significantly downregulated in nasal tissues from patients with AR and LPS-treated NECs. +circRNA target 32281302 hsa-mir-141 Carcinoma, Hepatocellular 3p, while piplartine can participate in the development of HCC by inhibiting the expression of circ-100338. +other 32281274 hsa-mir-23b Lung Neoplasms MiR-23b might be an up-and-coming biomarker of lung cancer. +circulation_biomarker_diagnosis_ns 32281166 hsa-mir-125b Arthritis, Rheumatoid METHODS: The plasma samples were obtained from 96 active RA patients who underwent 24-week IFX treatment and from 96 healthy controls to detect miR-125a and miR-125b expressions by RT-qPCR. +circulation_biomarker_diagnosis_ns 32280688 hsa-mir-9 Cervical Intraepithelial Neoplasia CONCLUSIONS: Circulating miRNAs can be a promising noninvasive diagnostic biomarker for CIN and early CC, especially miR-9 and miR-205, which need to be verified by large-scale studies. +circulation_biomarker_diagnosis_ns 32280688 hsa-mir-205 Cervical Intraepithelial Neoplasia CONCLUSIONS: Circulating miRNAs can be a promising noninvasive diagnostic biomarker for CIN and early CC, especially miR-9 and miR-205, which need to be verified by large-scale studies. +circulation_biomarker_diagnosis_ns 32280688 hsa-mir-9 Uterine Cervical Neoplasms CONCLUSIONS: Circulating miRNAs can be a promising noninvasive diagnostic biomarker for CIN and early CC, especially miR-9 and miR-205, which need to be verified by large-scale studies. +circulation_biomarker_diagnosis_ns 32280688 hsa-mir-205 Uterine Cervical Neoplasms CONCLUSIONS: Circulating miRNAs can be a promising noninvasive diagnostic biomarker for CIN and early CC, especially miR-9 and miR-205, which need to be verified by large-scale studies. +lncRNA target 32280304 hsa-mir-338 Leukemia, Myeloid, Acute 3p axis repressed the AML progression through regulating CREBRF, which might afford a favorable perspective for the AML treatment molecularly. +lncRNA target 32280303 hsa-mir-1204 Glioblastoma Furthermore, miR-1204 targeted and inhibited Nuclear receptor subfamily 3 group C member 2 (NR3C2), a tumor suppressor gene in GBM cells. +lncRNA target 32280300 hsa-mir-612 Small Cell Lung Carcinoma Moreover, TNF receptor associated factor 4 (TRAF4) was the target gene of miR-3612 in SCLC. ZFPM2-AS1, miR-3612 and TRAF4 jointly constituted a competing endogenous RNA (ceRNA) network in SCLC. +transcription factor target 32280275 hsa-mir-149 Lung Neoplasms miR5p negatively regulated B3GNT3 expression, which might be utilized for therapeutic target in lung cancer. +circulation_biomarker_diagnosis_up 32280273 hsa-mir-16 Lymphoma, Mantle-Cell METHODS: In this study, MORT and miRNA-16 were both downregulated in plasma of mantle cell lymphoma (MCL) patients than that in the controls. CONCLUSION: Therefore, MORT may inhibit cancer cell proliferation and promote apoptosis in mantle cell lymphoma by upregulating miRNA-16. +lncRNA target 32280246 hsa-mir-122 Carcinoma, Non-Small-Cell Lung 5p might serve as a new valuable therapeutic target for NSCLC. +lncRNA target 32280243 hsa-mir-137 Pancreatic Carcinoma Silencing HOTTIP or over-expression of miR-137 can increase the sensitivity of pancreatic cancer cisplatin-resistant cells to cisplatin, inhibit the proliferation of pancreatic cancer cells, and promote apoptosis. +genetics_overexpression_promote 32280242 hsa-mir-192 Colorectal Neoplasms Besides that overexpressed FTX positively modulated EIF5A2, a direct target of miR +circulation_biomarker_diagnosis_ns 32280240 hsa-mir-21 Lung Neoplasms CONCLUSION: Overall, our findings suggested that circulating miR-21 played important roles in osteoclastogenesis of lung cancer patients and may serve as a biomarker to diagnose BM of lung cancer. +genetics_overexpression_promote 32280078 hsa-mir-1294 Carcinoma, Hepatocellular More importantly, proliferation was further suppressed in ATO-induced HCC cells after overexpression of miR-1294. +lncRNA target 32279994 hsa-mir-3174 Carcinoma, Hepatocellular MiR-3174 may be a novel candidate for targeted delivery of miRNA therapeutics for HCC patients. +circulation_biomarker_diagnosis_up 32279913 hsa-mir-196a-2 Asthma CONCLUSIONS: Altered miR-196a2 expression and serum ANXA1 concentration may play a role in the pathogenesis of asthma. +lncRNA target 32279420 hsa-mir-125 Glioblastoma HOTAIR promoted the expression of HK2 by targeting mir-125, which suppressed the GBM cell proliferation and increased the TMZ-induced apoptosis. These findings shed light on a new therapeutic strategy in modulating HOTAIR/miR-125, which may interfere with the expression of HK2, and enhance the therapeutic sensitivity of GBM to TMZ. +lncRNA target 32279214 hsa-mir-518c Glioma Similarly, SOCS5 (suppressor of cytokine signaling 5) was found to bind with miR-518c-3p, which repressed glioma tumorigenesis by targeting SOCS5. +genetics_overexpression_promote 32279128 hsa-mir-4317 Breast Neoplasms Overexpression of miR-4317 inhibited proliferation, migration, and invasion of breast cancer cells, while downregulation of miR-4317 exhibited the opposite effects. +other 32278855 hsa-mir-199a Carcinoma, Non-Small-Cell Lung Collectively, our data showed that miR-199a-5p regulated expression of ABCC1 and HIF-1alpha were involved in Dox resistance of NSCLC. +lncRNA target 32278833 hsa-mir-144 Aortic Aneurysm, Abdominal 5p and its targets TLR2 and OLR1 provides therapeutic potential for limiting AAA formation. +other 32278326 hsa-mir-135b Diabetes Mellitus Here, in vivo experiments found that compared to the control group, miR-135b expression was significantly up-regulated in the diabetes group, whereas BMP7 mRNA and protein levels were down-regulated. +lncRNA target 32278306 hsa-mir-183 Carcinoma, Hepatocellular Overall, human LNC-HC was identified as a novel tumor suppressor that could inhibit HCC cell proliferation in vitro and suppress tumor growth in vivo by competitively binding hsa-miR +lncRNA target 32278305 hsa-mir-26a Diabetes Mellitus, Type 2 Our findings highlight the potential of miR-26a as a therapeutic target for diabetes mellitus-related bone metabolism and diseases. +transcription factor target 32278027 hsa-mir-128 Neuralgia 3p alleviated the progression of neuropathic pain via modulating ZEB1. +lncRNA target 32277959 hsa-mir-195 Acute Lung Injury CONCLUSIONS: The above results showed that the suppression of miR-195 ameliorated ALI through inhibiting apoptosis and oxidative stress via targeting Pim-1. +other 32277959 hsa-mir-15 Acute Lung Injury Recent studies have shown that miR-195, a critical member of miR-15 family, has modulated the apoptosis in various organic diseases. +transcription factor target 32277954 hsa-mir-18a Diabetes Mellitus CONCLUSION: Targeted activation of miR-18a/19a transcription levels and subsequent regulation of TSP-1 expression may be a novel therapeutic strategy for DFU. +transcription factor target 32277954 hsa-mir-19a Diabetes Mellitus CONCLUSION: Targeted activation of miR-18a/19a transcription levels and subsequent regulation of TSP-1 expression may be a novel therapeutic strategy for DFU. +lncRNA target 32277945 hsa-mir-652 Dyslipidemias 3p inhibition. +other 32277848 hsa-mir-155 Dengue In the present study, we observed that miR-155 time-dependently downregulated upon dengue virus (DENV) infection. +genetics_overexpression_promote 32277674 hsa-mir-22 Glioma The expression of SNAIL1 was also enhanced in all the glioma cells and miR-22 overexpression could cause suppression of the SNAIL1 expression in U-87 cells. +genetics_overexpression_promote 32277671 hsa-mir-187 Osteosarcoma The expression of MAPK7 was found to be significantly upregulated in osteosarcoma cells and overexpression of MAPK7 could nullify the effects of miR-187 on the proliferation of the osteosarcoma cells. +other 32277655 hsa-mir-1 Squamous Cell Carcinoma of Head and Neck 3p was significantly upregulated in well and moderately differentiated LSCC. +other 32277655 hsa-mir-424 Squamous Cell Carcinoma of Head and Neck 3p was significantly upregulated in well and moderately differentiated LSCC. +genetics_overexpression_promote 32277654 hsa-mir-205 Nasopharyngeal Carcinoma The expression of HER3 was found to be significantly upregulated in nasopharyngeal carcinoma cells and overexpression of HER3 could nullify the effects of miR-205 on the proliferation of nasopharyngeal carcinoma cells. +genetics_GWAS 32277629 hsa-let-7 Breast Neoplasms The purpose of this study was to determine the association between rs712 polymorphism in a let-7 microRNA-binding KRAS gene comparing breast cancer (BC) patients with healthy subjects from Mexican population. +genetics_GWAS 32277629 hsa-let-7m Breast Neoplasms The purpose of this study was to determine the association between rs712 polymorphism in a let-7 microRNA-binding KRAS gene comparing breast cancer (BC) patients with healthy subjects from Mexican population. +genetics_overexpression_promote 32277626 hsa-mir-22 Breast Neoplasms Overexpression of miR-322 led to considerable decline in the proliferation rate and colony formation of the MCF7 breast cancer cells due to induction of apoptosis. +lncRNA target 32277605 hsa-mir-421 Squamous Cell Carcinoma of Head and Neck E-cadherin axis could be a new therapeutic target for HNSCC. +circRNA target 32277518 hsa-mir-139 Uterine Cervical Neoplasms 3p, thereby relieving the transcriptional inhibition of Bcl-6. +lncRNA target 32277517 hsa-mir-520a Triple Negative Breast Neoplasms Further, data from rescue assays revealed that SOX21-AS1 could regulate the malignancy of TNBC via miR-520a-5p/ORMDL3 axis. All in all, we identified that SOX21-AS1 regulated the cellular process of TNBC cells via antagonizing miR-520a-5p availability to upregulate ORMDL3 expression. +genetics_knock down_promote 32277510 hsa-mir-124 Parkinson Disease Similarly, knockdown MALAT1 could improve behavioral changes and reduce apoptosis by miR +genetics_overexpression_suppress 32277427 hsa-mir-590 Corneal Dystrophy, Juvenile Epithelial of Meesmann 3p-overexpressing conditioned medium on HDMEC angiogenesis were partially reversed by VEGFA-overexpressing conditioned medium. +lncRNA target 32277152 hsa-mir-520f Stomach Neoplasms Together our findings thus suggest that miR-520f-3p can act to suppress GC progression, at least in part via suppressing SOX9 expression and thus disrupting Wnt/beta-catenin signaling. +circulation_biomarker_diagnosis_ns 32277149 hsa-mir-126 Acute Coronary Syndrome, Non-St Elevation Of the 19 significant microRNAs, three, miR-15b-5p, miR-93 and miR-126, were consistently associated with PR in the TRILOGY-ACS and independent Singapore post-ACS cohorts, suggesting the measurement of circulating microRNA concentrations may report on dynamic changes in platelet biology following a cardiovascular ischemic event. +circulation_biomarker_diagnosis_ns 32277149 hsa-mir-93 Acute Coronary Syndrome, Non-St Elevation Of the 19 significant microRNAs, three, miR-15b-5p, miR-93 and miR-126, were consistently associated with PR in the TRILOGY-ACS and independent Singapore post-ACS cohorts, suggesting the measurement of circulating microRNA concentrations may report on dynamic changes in platelet biology following a cardiovascular ischemic event. +circulation_biomarker_diagnosis_ns 32277149 hsa-mir-15b Acute Coronary Syndrome, Non-St Elevation Of the 19 significant microRNAs, three, miR-15b-5p, miR-93 and miR-126, were consistently associated with PR in the TRILOGY-ACS and independent Singapore post-ACS cohorts, suggesting the measurement of circulating microRNA concentrations may report on dynamic changes in platelet biology following a cardiovascular ischemic event. +circulation_biomarker_diagnosis_ns 32276307 hsa-mir-20a ST Elevation Myocardial Infarction Furthermore, the increase in circulating miR-320a and the decrease in its expression in PBMCs were significantly associated with LVAR and correlated with the expression of miR-320a in human failing myocardium from ischaemic origin. +genetics_knock down_promote 32276209 hsa-mir-16 Colorectal Neoplasms 5p, was suppressed by PVT1 knockdown in CRC cells. +lncRNA target 32275999 hsa-mir-654 Diabetic Nephropathies These findings revealed that circ_0000285 promoted podocyte injury via sponging miR +other 32275975 hsa-mir-21 Melanoma 5p and miR-146a-5p expression in superficially spreading melanoma, in association with BT measurement, could aid pathologists in SSM staging. +other 32275975 hsa-mir-146a Melanoma 5p and miR-146a-5p expression in superficially spreading melanoma, in association with BT measurement, could aid pathologists in SSM staging. +exosome 32275391 hsa-mir-155 Colitis Moreover, exosome-mediated miR-155 inhibitor delivery significantly prevented DSS-induced colitis. +other 32275350 hsa-mir-29b Glioblastoma miR-29b potentiates TMZ sensitivity against GBM cells by inducing autophagy and the combined use of miR-29 mimic and TMZ might represent a potential therapeutic strategy for GBM patients. +other 32275350 hsa-mir-29 Glioblastoma miR-29b potentiates TMZ sensitivity against GBM cells by inducing autophagy and the combined use of miR-29 mimic and TMZ might represent a potential therapeutic strategy for GBM patients. +lncRNA target 32275336 hsa-mir-491 Adenocarcinoma of Lung 5p inhibition could reverse the inhibitory effect of WDFY3-AS2 silence on LUAD progression. +lncRNA target 32275316 hsa-mir-1271 Carcinoma, Hepatocellular 5p inhibits cell proliferation and enhances the radiosensitivity of HCC cell lines by targeting CDK1. +lncRNA target 32275162 hsa-mir-342 Prostatic Neoplasms Conclusion: ZEB1-AS1 modulated PCa progression through mediating PI3K/AKT/mTOR signaling by miR +lncRNA target 32274860 hsa-let-7 Fibrosis, Vascular Further, the expression of let-7i decreased after MCAO, but was reversed by antagonist of TGF-betaR1 or inhibition of Mek phosphorylation. +genetics_overexpression_promote 32274860 hsa-let-7i Fibrosis, Vascular Through specifically overexpressed let-7i in ECs, we found that it reduced TGF-betaR1, endMT, and vascular fibrosis. In summary, we concluded that ischemic stroke activates a let-7i/TGF-betaR1 double-negative feedback loop, thereby inducing endMT and vascular fibrosis. +lncRNA target 32274658 hsa-mir-382 Osteosarcoma To sum up, it can be concluded that circ-0002052, functioning as a sponge for miR-382, enhances the activation of Wnt/beta-catenin mediated by STX6 to stimulate the progression of OS, and circ-0002052 may be an underlying treatment target and a biomarker for prognosis of osteosarcoma. +other 32274407 hsa-mir-199a Fetal Growth Retardation "The dataset supports the research article entitle ""Whole genome miRNA profiling revealed miR-199a as potential placental pathogenesis of selective fetal growth restriction in monochorionic twin pregnancies"" [1]." +epigenetics 32274392 hsa-mir-200c Colorectal Neoplasms Conclusion The DNA methylation status of the miR-200c/141 cluster could serve as a progression marker from benign polyps to colorectal cancer. +epigenetics 32274392 hsa-mir-141 Colorectal Neoplasms Conclusion The DNA methylation status of the miR-200c/141 cluster could serve as a progression marker from benign polyps to colorectal cancer. +lncRNA target 32273770 hsa-mir-506 Glioma The reintroduction of BCAT1 in glioma cells abolished the tumor suppressive function of miR-506 by promoting cell viability and motility. CONCLUSION: Our data revealed that LINC00963 confers oncogenic function in the progression of glioma and that the LINC00963/miR-506/BCAT1 axis may be a novel mechanism and therapeutic strategy for this disease. +genetics_overexpression_suppress 32273766 hsa-mir-802 Colorectal Neoplasms CONCLUSION: In conclusion, our study shows that miR-802 is downregulated in colorectal cancer, and overexpression of miR-802 inhibits colorectal cancer cell viability, migration and invasion by directly targeting RAN. +genetics_knock down_suppress 32273759 hsa-mir-532 Carcinoma, Renal Cell Furthermore, rescue assays revealed that inhibiting miR-532 or restoring ETS1 expression partially abolished the impacts of CASC19 knockdown on ccRCC cells. CONCLUSION: The CASC19/miR-532/ETS1 regulatory pathway is crucial for the malignant manifestations of ccRCC, which makes it an attractive target for potential treatments of ccRCC. +genetics_knock down_promote 32273754 hsa-mir-654 Ovarian Neoplasms Ectopic expression of PD-L1 reversed the anti-cancer functions by EMX2OS knockdown, AKT3 silencing or miR-654 upregulation in OC cells. +lncRNA target 32273727 hsa-mir-6833 Colorectal Neoplasms CONCLUSION: We concluded that LINC-RoR functions as an oncogene in CRC through the miR3p/SMC4 pathway. +genetics_overexpression_promote 32273724 hsa-mir-26a Stomach Neoplasms CONCLUSION: Overexpressed miR-26a-5p can inhibit Wnt5a expression, promote cell apoptosis, and suppress cell proliferation and invasion in GC. +lncRNA target 32273723 hsa-mir-1224 Prostatic Neoplasms CONCLUSION: LINC00665 is a novel oncogenic gene in PC by targeting miR +genetics_knock down_promote 32273720 hsa-mir-644a Urinary Bladder Neoplasms Moreover, we also showed that miR-644a was also highly expressed in bladder cancer cells and inhibition of miR-644a or overexpression of TLX1 can increased the migration abilities of bladder cancer caused by knockdown of BCAR4. CONCLUSION: We showed that BCAR4 sponged miR-644a to modulate the expression of TLX1 and promote bladder cancer development. +lncRNA target 32273718 hsa-mir-126 Colorectal Neoplasms induced can regulate the activity of CRC cells via autophagy and apoptosis and suggested a new mechanism of miR +transcription factor target 32273714 hsa-mir-876 Carcinoma, Non-Small-Cell Lung 3p/SPRR3/EZH2 signaling cascade exerts important roles in the regulation of NSCLC, suggesting that this pathway can serve as a potential therapeutic target in NSCLC. +lncRNA target 32273713 hsa-mir-188 Nasopharyngeal Carcinoma In addition, miR-188 suppressed NPC cell growth via directly targeting ELF2. +lncRNA target 32273712 hsa-mir-473 Colorectal Neoplasms The Circ_0060745/miR-4736/CSE1L axis might be a novel target for the treatment of CRC. +lncRNA target 32273712 hsa-mir-4736 Colorectal Neoplasms The Circ_0060745/miR-4736/CSE1L axis might be a novel target for the treatment of CRC. +genetics_knock down_suppress 32273558 hsa-mir-124 Multiple Sclerosis miR-124, an anti-inflammatory marker but also of myeloid cell quiescence was strongly downregulated, especially in progressive MS patients, suggesting complete loss of homeostatic monocyte function in the progressive disease phase. +lncRNA target 32272979 hsa-mir-202 Carcinoma, Hepatocellular In conclusion, miR-202 serves as a tumor suppressor in HCC progression by downregulating BCL2 expression, indicating miR-202 might be a potential target for HCC. +exosome 32272965 hsa-mir-124 Spinal Cord Ischemia 3p derived from BMMSCs attenuated nerve injury induced by SCIRI by regulating Ern1 and M2 macrophage polarization. +lncRNA target 32272940 hsa-mir-24 Carcinoma, Hepatocellular CONCLUSION: Linc01134/miR5p/IGF2BP1/YY1 feedback loop mediates HCC progression, which possibly provide prognosis and treatment target of HCC. +genetics_knock down_suppress 32272873 hsa-mir-195 Ischemic Stroke METHODS: Ischemic stroke rat models were established by middle cerebral artery occlusion (MCAO), and oxygen deprivation (OGD) models were constructed in rat neuronal cells, followed by gain- or loss-of-function of miR-195 and/or KLF5 in rats and cells. +genetics_overexpression_promote 32271958 hsa-mir-519a Ovarian Neoplasms Here we report that while overexpression of miR-519a-5p in ovarian cancer cells inhibited the Warburg effect, inhibition of miR-519a-5p negated the suppressive action of 20(S)-Rg3 against the Warburg effect as evidenced by a decrease in glucose consumption, lactate production and HK2 expression. +other 32271829 hsa-mir-126 Turner Syndrome 3p was lower in TS patients with congenital aortic valve disease (AVD) compared to TS patients without BAV (p = 0.0139, log2-fold change 1.52). +other 32271829 hsa-mir-5695 Turner Syndrome 3p was lower in TS patients with congenital aortic valve disease (AVD) compared to TS patients without BAV (p = 0.0139, log2-fold change 1.52). +lncRNA target 32271695 hsa-mir-510 Carcinoma, Renal Cell CONCLUSION: Circ-SCARB1 promotes RCC progression via sequestering miR5p and indirectly up-regulating SDC3 expression. +lncRNA target 32271641 hsa-mir-195 Ischemic Stroke CONCLUSIONS: Our finding uncovers the protective effect of miR-195 on the biological behavior of HUVECs via suppression of the NF-kappaB pathway induced by IKKalpha, which may provide a new potential strategy for ischemic stroke clinical treatment. +lncRNA target 32271450 hsa-mir-19a Myocardial Reperfusion Injury CONCLUSIONS: MiR-19a inhibits the PTEN expression by directly binding to the 3'-UTR of PTEN mRNA, thus activating the Akt/p-Akt signaling pathway to suppress the apoptosis of myocardial cells in MIR injury. +lncRNA target 32271449 hsa-mir-28 Myocardial Reperfusion Injury The model of myocardial IR injury was established by ligating the left anterior descending coronary artery, without any intervention in the model group, while 200 muL of miR-328 antagomir was intravenously injected before modeling in the miR-328 group. CONCLUSIONS: MiR-328 modulates the MEK-ERK signaling pathway to inhibit cell apoptosis and improve the cardiac function in rats with myocardial IR injury. +genetics_overexpression_promote 32271448 hsa-mir-1253 Atherosclerosis CONCLUSIONS: According to the results, we found that FOXC2-AS1 was upregulated in AS patients; furthermore, FOXC2-AS1 overexpression promoted cell proliferation and inhibited cell apoptosis via targeting miR-1253/FOXF1 signaling axis. +circRNA target 32271446 hsa-mir-214 Angelman Syndrome CONCLUSIONS: Circ_CHFR contributed to the progression of AS through the miR3p/Wnt3/beta-catenin signals, which illuminated the molecular mechanism of AS and suggested circ_CHFR might be an index for AS treatment. +circulation_biomarker_diagnosis_up 32271441 hsa-mir-126 Intracranial Aneurysm QRT-PCR was used to detect the expression of miR-126 in serum, analyze the expression of miR-126 in IA, and explore the predictive value on IA rupture. +circulation_biomarker_diagnosis_up 32271441 hsa-mir-126 Intracranial Aneurysm QRT-PCR was used to detect the expression of miR-126 in serum, analyze the expression of miR-126 in IA, and explore the predictive value on IA rupture. +lncRNA target 32271438 hsa-mir-21 Glioma CONCLUSIONS: EZH2 was highly expressed in glioma cells and EZH2-mediated H3K27me3 enrichment on the MEG3 promoter regulated the growth and metastasis of glioma cells by targeting miR +genetics_overexpression_suppress 32271437 hsa-mir-29 Glioma RESULTS: XIST and CREB1 were overexpressed whereas miR +lncRNA target 32271435 hsa-mir-4469 Laryngeal Neoplasms CONCLUSIONS: This study uncovered that HCG11 sponged miR-4469 to suppress laryngeal carcinoma progression by upregulating APOM expression. +circulation_biomarker_diagnosis_up 32271434 hsa-mir-92b Lung Neoplasms MATERIALS AND METHODS: The expression levels of miR-92b and EZH2 in human bronchial epithelial cell line BEAS-2B and human lung cancer cell line (A549, NCI-H23, NCI-H358, NCI-H1975, PC-9) were detected, and miR-92b mimic, sh-EZH2 expression vector, and plasmid blank vector (blank group) were constructed. +lncRNA target 32271433 hsa-mir-498 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: Our results identified that LncRNA DUXAP8 could regulate cell proliferation, metastasis and EMT in NSCLC cells by inhibiting miR-498 through the activation of TRIM44-mediated AKT/mTOR pathway. +tissue_expression_ns 32271431 hsa-mir-18a Carcinoma, Non-Small-Cell Lung PATIENTS AND METHODS: The levels of CASC2 and miR-18a in cisplatin (DDP)-resistant NSCLC tissues and cell lines were evaluated by quantitative Polymerase Chain Reaction (qPCR). MiR-18a released by the declining expression of CASC2 reduced the protein concentration of IRF-2 in NSCLC cells. CONCLUSIONS: IRF-2 expression mediated by the ELF1/CASC2/miR-18a axis is markedly associated with the proliferation, migration, and invasion of cisplatin-resistant NSCLC, resulting in inferior survival. +lncRNA target 32271430 hsa-mir-193 Triple Negative Breast Neoplasms CONCLUSIONS: MiR-193 enhanced cell invasion-mediated EMT and improved cell proliferation through the ING5/PI3K/AKT signal pathway in triple-negative breast cancer. +transcription factor target 32271429 hsa-mir-526b Breast Neoplasms CONCLUSIONS: Thus, our evidence indicated that miR-526b may serve as a potential target of breast cancer treatment. +genetics_overexpression_promote 32271428 hsa-mir-548b Breast Neoplasms Subsequent in-vitro experiments indicated that the overexpression of miR-548b-3p significantly inhibited the proliferation and metastasis, whereas promoted the apoptosis of BC cells. +circRNA target 32271424 hsa-mir-496 Nasopharyngeal Carcinoma CONCLUSIONS: Hsa_circ_001193 can serve as the miR-496 sponge, which regulates proliferation and apoptosis of NPC cells through up-regulating miR-496. +lncRNA target 32271422 hsa-mir-326 Stomach Neoplasms Functionally, silencing DDX11-AS1 repressed the progression and OXA resistance in OXA-resistant GC cells by down-modulating IRS1 expression via sponging miR-326 in vitro and in vivo. +lncRNA target 32271421 hsa-mir-215 Stomach Neoplasms CONCLUSIONS: According to these results, this study revealed that the previously neglected FTX-miR2153p-SIVA1 regulatory axis for the regulation of gastric cancer progression, which may be a potential target for the treatment of gastric cancer. +lncRNA target 32271414 hsa-mir-140 Carcinoma, Renal Cell 5p/IGF1R pathway might be a promising therapeutic target in ccRCC. +other 32271413 hsa-mir-20a Urinary Bladder Neoplasms Our study investigated the function of miR-20a in bladder cancer and provided new insights into the treatment of bladder cancer. +lncRNA target 32271408 hsa-mir-488 Ovarian Neoplasms MiR-488 inhibited cell metastasis in OC by blocking EMT and promoting tumor suppressor p53 expression. +lncRNA target 32271407 hsa-mir-142 Osteoarthritis The inflammation group was further divided into BLACAT1 siRNA group and BLACAT1 siRNA+miR5p inhibitor group, followed by analysis of Lnc-RNA BLACAT1 expression by real time PCR, BMSCs proliferation, Caspase 3 activity, ALP activity, expression of Runx2, OC and PPARgamma2 by real time PCR, and secretion of TNF-alpha and IL-1beta by enzyme-linked immunosorbent assay (ELISA). +other 32271404 hsa-mir-24 Spinal Injuries However, the regulation and mechanism of miR-24 in oligodendrocyte precursor cell differentiation after spinal injury is unclear. CONCLUSIONS: MiR-24 expression is increased in spinal injury. +other 32271158 hsa-mir-622 Carcinoma, Non-Small-Cell Lung Further analysis of three differentially expressed miRNAs revealed that miR-320a, miR-622 and let-7f-5p levels could significantly segregate patients with metastatic NSCLC from patients with nonmetastatic NSCLC (p < 0.0001, p < 0.0001 and p = 0.023, respectively). In addition, the combination of let-7f-5p, CEA and Cyfra21-1 generated an area under the curve (AUC) of 0.981 for the diagnosis of NSCLC patients, and the combination of miR-320a, miR-622, CEA and Cyfra21-1 had an AUC of 0.900 for the diagnosis of patients with metastatic NSCLC. +other 32271158 hsa-mir-20a Carcinoma, Non-Small-Cell Lung Further analysis of three differentially expressed miRNAs revealed that miR-320a, miR-622 and let-7f-5p levels could significantly segregate patients with metastatic NSCLC from patients with nonmetastatic NSCLC (p < 0.0001, p < 0.0001 and p = 0.023, respectively). In addition, the combination of let-7f-5p, CEA and Cyfra21-1 generated an area under the curve (AUC) of 0.981 for the diagnosis of NSCLC patients, and the combination of miR-320a, miR-622, CEA and Cyfra21-1 had an AUC of 0.900 for the diagnosis of patients with metastatic NSCLC. +lncRNA target 32270853 hsa-mir-340 Gallbladder Neoplasms In the present study, LINC01694 was found to regulate the proliferation, invasion, as well as apoptosis in gallbladder cancer (GBC) cells through sponging miR +lncRNA target 32270599 hsa-mir-128 Acute Kidney Injury LINC00963 could target miR3p to reduce G1 arrest and apoptosis through JAK2/STAT1 pathway to promote the progression of AKI. +genetics_overexpression_promote 32270431 hsa-mir-202 Liver Cirrhosis RESULTS: We found that the expression level of miR-202 in serum of patients with liver fibrosis was significantly higher than that of healthy people, and increased with the increase of fibrosis; miR-202 inhibited the expression level of mRNA and protein of HGF by combining with the 3'-UTR of HGF; the expression level of miR-202 significantly increased after hepatic stellate cells (HSC) were stimulated by AngII; the overexpression of miR-202 could up-regulate the expression of fibrotic factors alpha-SMA, FSP1, and collagen I. +lncRNA target 32270193 hsa-mir-185 Leukemia, Myelogenous, Chronic, BCR-ABL Positive To investigate the role of microRNAs (miRNAs) in regulating drug resistance and leukemic stem cell (LSC) fate, we performed global transcriptome profiling in treatment-naive chronic myeloid leukemia (CML) stem/progenitor cells and identified that miR-185 levels anticipate their response to ABL tyrosine kinase inhibitors (TKIs). +transcription factor target 32269740 hsa-mir-29a Rhabdomyosarcoma These findings proved that mir-29 inhibits the occurrence of RMS and may be a potential molecular target. +transcription factor target 32269740 hsa-mir-29 Rhabdomyosarcoma These findings proved that mir-29 inhibits the occurrence of RMS and may be a potential molecular target. +other 32269738 hsa-mir-650 Carcinoma, Hepatocellular qRT-PCR results showed lower Axin1 expression level and higher miR-650 expression level in HCC. +exosome 32269736 hsa-mir-374a Liver Neoplasms Inhibition of miR-374a-5p in Hep3B cells resulted in exosomes that inhibited the proliferation, migration, and invasion of HCC cells. +genetics_overexpression_promote 32269720 hsa-mir-212 Ovarian Neoplasms, High-Grade Serous In addition, overexpression of miR +transcription factor target 32269710 hsa-mir-142 Fibrosis LPS and miR3p are potential diagnostic and therapeutic targets in cirrhosis. +genetics_knock down_promote 32269707 hsa-mir-499 Diabetic Cardiomyopathies Collectively, our study suggested that TUG1 knockdown attenuated DCM-induced cardiac hypertrophy and diastolic dysfunction by upregulating miR5p. +genetics_knock down_promote 32269707 hsa-mir-499 Heart Failure, Diastolic Collectively, our study suggested that TUG1 knockdown attenuated DCM-induced cardiac hypertrophy and diastolic dysfunction by upregulating miR5p. +genetics_knock down_promote 32269700 hsa-mir-22 Urinary Bladder Neoplasms In addition, E2F3 was a direct target of miR-22 and its knockdown attenuated the promotion of cell proliferation, migration, invasion, and EMT induced by miR-22 inhibitor in bladder cancer cells. +genetics_knock down_promote 32269684 hsa-mir-103 Carcinoma, Hepatocellular Gain-of-function and loss-of-function studies showed that miR-103 ectopic overexpression promoted, but miR-103 silencing reduced, heat-exposed HCC proliferation, and migration in vitro. +genetics_overexpression_promote 32269679 hsa-mir-519 Stomach Neoplasms Overexpression of FOXQ1 in gastric cancer cells reversed the inhibitory effect of miR-519 on cellular biologic behavior. +genetics_knock down_promote 32269676 hsa-mir-451a Breast Neoplasms In addition, miR-451a expression was obviously down-regulated in BC tissues and had negative correlation with SNHG12. CONCLUSION: Knockdown of SNHG12 inhibited cell proliferation, invasion, and migration by regulating miR-451a through suppression of AKT/mTOR pathway in BC. +transcription factor target 32269673 hsa-mir-124 Carcinoma, Hepatocellular 3p inhibits tumor growth, invasion, and lymphatic metastasis in HCC by down-regulation of ANXA7 gene, thereby reducing the expression of Bcl-2, MMP-9, and CXCL12. +genetics_knock down_suppress 32269632 hsa-mir-665 Lung Neoplasms When regulating the expression levels of miR-665 in vitro, NSCLC cell proliferation, migration and invasion were enhanced by overexpression of miR-665, but were inhibited by knockdown of miR-665. +other 32269622 hsa-mir-150 Plasmablastic Lymphoma Taken together, the results of the present study suggest that miR-150 is a potential diagnostic marker of PGI-DLBCL, and may also serve as a useful prognostic factor for survival outcomes in patients with PGI-DLBCL. +lncRNA target 32269615 hsa-mir-21 Prostatic Neoplasms Furthermore, miR-21 was upregulated in prostate carcinoma tissues compared with adjacent non-cancerous tissues and was inversely associated with Erbb4-IR expression in tumor tissues. Therefore, the results of the present study suggested that lncRNA Erbb4-IR is downregulated in prostate carcinoma and may inhibit cancer development by downregulating miR-21. +lncRNA target 32269214 hsa-mir-107 Thyroid Cancer, Papillary Inhibition of miR-107 suppressed PTC cell proliferation, invasion, and migration in vitro. In conclusion, we validated HOTAIRM1 as a novel tumor-suppressor lncRNA in PTC and proposed that the HOTAIRM1/miR-107/TDG axis may serve as a therapeutic target for PTC. +lncRNA target 32269209 hsa-mir-141 Ameloblastoma CONCLUSIONS In this study, highly expressed NCAM1 was found in AB, and it suppressed the migration of AB cells and was regulated by miR +genetics_knock down_promote 32268875 hsa-mir-139 Glioma CONCLUSION: circKIF4A was overexpressed in glioma, and knockdown of circKIF4A suppressed glioma progression via miR +genetics_overexpression_promote 32268810 hsa-mir-21 Esophageal Squamous Cell Carcinoma OBJECTIVE: Overexpression of microRNA-21 (miR-21) increases the radiation resistance of esophageal squamous cell carcinoma (ESCC). +genetics_knock down_promote 32268136 hsa-mir-146a Breast Neoplasms METHODS: Exosomes (Exo-MA, Exo-M7, Exo-M1) were extracted from normal breast epithelial cells (MCF-10A), BC cells (MCF-7/MDA-MB-231) and BC cells with miR-146a overexpression or knockdown using multi-step differential centrifugation. CONCLUSION: BC-derived exosomes promote the activation of CAFs through miR-146a/TXNIP axis to activate Wnt pathway, which in turn enhances invasion and metastasis of BC cells. +genetics_overexpression_promote 32268073 hsa-mir-142 Myocardial Infarction Overexpression of miR +genetics_overexpression_promote 32268073 hsa-mir-212 Myocardial Infarction Overexpression of miR +genetics_overexpression_promote 32267991 hsa-mir-487b Osteosarcoma miR-487b was overexpressed in OS tissues and was inversely associated with the prognosis of OS patients. +exosome 32267797 hsa-mir-106a Stomach Neoplasms Collectively, we revealed that the delivery of miR-106a from GC-exos plays a crucial role in gastric cancer peritoneal metastasis.Abbreviations: MiR-106a: microRNA-106a; Smad7: small mothers against decapentaplegic 7; GC: gastric cancer; MCs: mesothelial cells; Exos: exosomes; HG: high-differentiated gastric cancer cells; LG: low-differentiated gastric cancer cells. +lncRNA target 32267722 hsa-mir-223 Reperfusion Injury, Pulmonary Ischemia Taken together, miR-223 inhibits HIF2alpha to repress beta-catenin, thus contributing to autophagy to complicate lung I/R injury. +genetics_GWAS 32267380 hsa-mir-9-1 Periodontitis CONCLUSION: The polymorphism -149C-->T in DNMT3B (rs2424913) and the methylated profile of the miR +epigenetics 32267167 hsa-mir-137 Squamous Cell Carcinoma of Head and Neck The transfection of miR-137 mimic reduced the KI67 and Rb proteins and proliferation of OSCC cells. Conclusion: Our results show for the first time a relationship between SET and histone methylation associated with the control of miRNA expression and KI67 and Rb as targets of miR-137 in OSCC. +circulation_biomarker_diagnosis_up 32267166 hsa-mir-335 Breast Neoplasms CONCLUSIONS: Detection of the miR-29a and miR335 expression levels in serum samples are significant promising biomarkers for BC diagnosis. +circulation_biomarker_diagnosis_up 32267166 hsa-mir-29a Breast Neoplasms CONCLUSIONS: Detection of the miR-29a and miR335 expression levels in serum samples are significant promising biomarkers for BC diagnosis. +other 32267161 hsa-mir-153 Squamous Cell Carcinoma of Head and Neck 3p combination could be a valuable diagnostic and prognostic predictor for HNSCC. +transcription factor target 32267139 hsa-mir-217 Carcinoma, Non-Small-Cell Lung CONCLUSION: Hsa-miR-217 and its target sirtuin 1 acted as metastasis suppressor and promoter gene in non-small cell lung cancer, respectively. +lncRNA target 32266868 hsa-mir-125a Stomach Neoplasms MicroR-125a-5p, a candidate microRNA that target on insulin-like growth factor 2 messenger RNA-binding protein 3, decreased in advanced-stage gastric cancer. These results indicate that the microR-125a-5p/insulin-like growth factor 2 messenger RNA-binding protein 3 axis contributes to the oncogenesis of advanced gastric cancer. +genetics_overexpression_suppress 32266863 hsa-mir-134 Stroke Our present study reported that HIF-1alpha overexpression protected PC12 cells against OGD/R-evoked injury via down-regulation of miR-134, which making HIF-1alpha and miR-134 to be promising targets for cerebral stroke therapy. +genetics_knock down_suppress 32266816 hsa-mir-326 Thyroid Cancer, Papillary MAPK1 or ERBB4 overexpression rescued the effects of miR-326 on proliferation, migration, and invasion in PTC cells. +genetics_overexpression_promote 32266733 hsa-mir-646 Retinoblastoma Overexpression of circ_0000527 promoted the viability, migration and invasion of RB cells, while miR-646 transfection had the opposite effects. +lncRNA target 32266659 hsa-mir-186 Carcinoma, Renal Cell In conclusion, miR-186 suppresses proliferation, migration and invasion of RCC by inhibiting CDK6 expression. +other 32266559 hsa-mir-15a Head and Neck Neoplasms Finally, multivariate Cox regression analysis revealed that miR-15a-5p may serve as an independent predictive biomarker of LPFS in HNSCC patients treated with IMRT (HR 0.104; 95% CI 0.004-0.911; p = 0.04). CONCLUSIONS: We conclude that salivary miR-15a-5p may represent a potential biomarker for individualized treatment decision-making in HNSCC patients. +lncRNA target 32266420 hsa-mir-489 Leukemia, Myeloid, Acute CONCLUSIONS: Our results demonstrated that SNHG5 affected the expression of SOX4 through binding miR3p to regulate proliferation and apoptosis of AML, which might act as a prospective prognostic biological marker and a promising therapeutic target for AML. +lncRNA target 32266320 hsa-mir-613 Laryngeal Neoplasms CONCLUSION: LINC00152 exerts an oncogenic effect on the tumorigenesis of LSCC by sponging miR-613 and may serve as a potential target for treating LSCC. +lncRNA target 32266319 hsa-mir-204 Atherosclerosis 5p plays an important role in the growth and migration of hVSMCs by targeting MMP-9, which might be a novel biomarker and promising therapeutic target for AS. +other 32266268 hsa-mir-21 Aristolochic Acid Induced Nephropathy Furthermore, meta-analyses of miRNAs downregulated by MSC-EVs, such as miR21, revealed the regulation of multiple pathways involved in kidney injury including fibrosis, inflammation, and apoptosis. +genetics_overexpression_suppress 32266103 hsa-mir-590 Triple Negative Breast Neoplasms Importantly, overexpression of Slug reversed the inhibitory effect of miR +circulation_biomarker_diagnosis_up 32266038 hsa-mir-767 Carcinoma, Non-Small-Cell Lung The expression of miR-767 was increased in NSCLC serum, tissues and cells compared with controls. +lncRNA target 32266037 hsa-mir-25 Carcinoma, Pancreatic Ductal In conclusion, these findings demonstrate that miR-25 plays an oncogenic role and promotive role in PDAC cell proliferation via targeting of ABI2. +circulation_biomarker_diagnosis_ns 32266032 hsa-mir-190a Heart Failure, Chronic Serum expression of PVT1 increased, while serum expression of miR-190a-5p decreased in patients with CHF compared with healthy controls (all P<0.001). +circulation_biomarker_diagnosis_ns 32266032 hsa-mir-190 Heart Failure, Chronic Serum expression of PVT1 increased, while serum expression of miR-190a-5p decreased in patients with CHF compared with healthy controls (all P<0.001). +other 32266029 hsa-mir-28 Carcinoma, Non-Small-Cell Lung 5p. +genetics_knock down_promote 32266028 hsa-mir-654 Laryngeal Neoplasms In summary, the present study reported that knockdown of SOX2-OT could suppress cell proliferation, migration and invasion, and induce apoptosis in laryngeal cancer by targeting miR-654. +genetics_knock down_promote 32266016 hsa-mir-106b Osteosarcoma Furthermore, upregulation of CDKN1A expression mimicked, whilst CDKN1A knockdown reversed the suppressive effects of miR-106b-5p inhibitor on OS cell proliferation and cell cycle progression. +lncRNA target 32265979 hsa-mir-200a Colorectal Neoplasms The potential roles of the tumor suppressor miR-200a-3p in invasion, migration, and epithelial-mesenchymal transition of CRC cells were elaborated by in vitro studies. +lncRNA target 32265694 hsa-mir-1972 Osteosarcoma Taken together, our findings indicate that LINC00588 plays a role in OS development by downregulating the expression of miRNA-1972, which can, in turn, inhibit the expression of TP53. +lncRNA target 32265694 hsa-mir-1072 Osteosarcoma Hence, we believe that the LINC00588/miRNA-1072/TP53 axis could potentially serve as a therapeutic target or diagnostic biomarker for osteosarcoma. +lncRNA target 32265386 hsa-mir-18b Melanoma Silencing lncRNA H19 inhibited colony formation ability and promoted apoptosis of DDP-resistant melanoma cells, which was abrogated by miR-18b inhibition and IGF1 upregulation. +genetics_GWAS 32265338 hsa-mir-16-1 Ischemic Stroke These findings suggest that genetic deletion of endothelial miR-15a/16-1 suppresses BBB pathologies after ischemic stroke. +genetics_GWAS 32265338 hsa-mir-15a-1 Ischemic Stroke These findings suggest that genetic deletion of endothelial miR-15a/16-1 suppresses BBB pathologies after ischemic stroke. +genetics_GWAS 32265338 hsa-mir-15a Ischemic Stroke These findings suggest that genetic deletion of endothelial miR-15a/16-1 suppresses BBB pathologies after ischemic stroke. +genetics_overexpression_promote 32265096 hsa-mir-10b Oral Submucous Fibrosis RESULTS: MiR-10b expression was overexpressed in both OSF tissues and fBMFs. +lncRNA target 32264877 hsa-mir-637 Triple Negative Breast Neoplasms Further mechanism research demonstrated that circSEPT9 could regulate the expression of Leukemia Inhibitory Factor (LIF) via sponging miR-637 and activate LIF/Stat3 signaling pathway involved in progression of TNBC. +genetics_knock down_promote 32264733 hsa-mir-140 Nasopharyngeal Carcinoma 3p inhibition or Twist1 overexpression. +lncRNA target 32264732 hsa-mir-744 Uterine Cervical Neoplasms Bcl-2 pathway may be involved in cervical cancer pathogenesis and could serve as a novel target for anticancer therapies. +genetics_overexpression_promote 32264665 hsa-mir-31 Spinal Cord Injuries Overexpression of miR +genetics_overexpression_promote 32264665 hsa-mir-31 Neuralgia Overexpression of miR +other 32264534 hsa-mir-145 Endometrial Hyperplasia It was suggested that encapsulation of miRNA-145 complexes in small-diameter scaffolds could serve as an effective approach to prevent intimal hyperplasia during vascular tissue regeneration. +lncRNA target 32260566 hsa-mir-145 Cystic Fibrosis 5p present within the 3'UTR of the CFTR mRNA and to determine its activity in inhibiting miR +other 32260540 hsa-mir-106b Stomach Neoplasms We aimed to determine the expression of microRNA-106b-5p and TRAIL in patients with gastric diseases, infected by H. pylori decreases microRNA-106b-5p expression and that this is a carcinogenic bacterium responsible for gastric diseases. +genetics_overexpression_suppress 32260128 hsa-mir-181a Triple Negative Breast Neoplasms Among them, miR-181a-5p was found to be overexpressed in ERbeta+ tumors and predicted target key components of the cholesterol biosynthesis pathway previously found to be inhibited by ERbeta in TNBC cells. +transcription factor target 32259627 hsa-mir-101 Mouth Neoplasms 3p enhanced apoptosis and suppressed cell viability in oral cancer by suppressing BICC1 expression. +transcription factor target 32259627 hsa-mir-199b Mouth Neoplasms Upregulation of miR-199b-5p and miR3p inhibited the viability and promoted the apoptosis in TSCCA and SCC-9 cells, as shown by the CCK8 assay and flow cytometry analysis, respectively. +other 32259568 hsa-mir-26b Aspermia And miR-374b and miR-26b could serve as adjunct biomarkers for the diagnosis of idiopathic infertile males. +other 32259568 hsa-mir-374b Aspermia And miR-374b and miR-26b could serve as adjunct biomarkers for the diagnosis of idiopathic infertile males. +lncRNA target 32259551 hsa-mir-9 Chemical and Drug Induced Liver Injury Hence we aimed to investigate the involvement of TLR4-induced modulation of TGF-beta receptor 1 (TGF-betaR1) signaling as well as the implication of miRNA-9 and 29 in CIS-induced hepatotoxicity. Accordingly, it may be assumed that the protective effect of CROC against CIS-induce hepatotoxicity is mediated via the crosstalk of TLR4/NF-kappaBp50 signaling and BAMBI modulation of TGF-beta1 activity in addition to the up-regulation of miRNA-9 and 29. +transcription factor target 32258386 hsa-mir-489 Melanoma 3p suppresses SIX1 expression by directly targeting its 3' untranslated region (3' UTR) in melanoma cells. +genetics_overexpression_suppress 32258242 hsa-mir-145 Neuroblastoma Herein, we sought to evaluate the effects of miR-145 overexpression in chemo and radiation-resistant neuroblastoma cells. +lncRNA target 32258130 hsa-let-7c Cataract, Age-Related Nuclear CONCLUSION: Let-7c-3p inhibits autophagy by targeting ATG3 in LECs in age-related cataract. +lncRNA target 32258130 hsa-let-7c Aicardi-Goutieres syndrome 5 CONCLUSION: Let-7c-3p inhibits autophagy by targeting ATG3 in LECs in age-related cataract. +lncRNA target 32258130 hsa-let-7c Cataract CONCLUSION: Let-7c-3p inhibits autophagy by targeting ATG3 in LECs in age-related cataract. +other 32258122 hsa-mir-582 Carcinoma, Non-Small-Cell Lung An independent dataset of miRNA microarray profiles was used to validate the expression of mature miR5p in patients with advanced lung adenocarcinoma. +other 32257949 hsa-mir-122 Carcinoma, Hepatocellular 5p axes were defined as two key pathways in carcinogenesis of hepatocellular carcinoma by combination of in silico analysis and experimental validation. +other 32257949 hsa-mir-497 Carcinoma, Hepatocellular 5p axes were defined as two key pathways in carcinogenesis of hepatocellular carcinoma by combination of in silico analysis and experimental validation. +other 32257949 hsa-mir-195 Carcinoma, Hepatocellular 5p axes were defined as two key pathways in carcinogenesis of hepatocellular carcinoma by combination of in silico analysis and experimental validation. +other 32257639 hsa-mir-196b Coronary Artery Disease In particular, hsa-miR-196a-5p and hsa-miR-196b-5p may be more reliably associated with CAD. CONCLUSIONS: Between EAT and SAT in CAD patients, a total of 89 DEGs, and 10 key genes, including HOXA5, HOXB5, HOXC6, HOXC8, HOXB7, COL1A1, CCND1, CCL2, HP and TWIST1, and miRNAs hsa-miR-196a-5p and hsa-miR-196b-5p were predicted to play essential roles in CAD pathogenesis. +other 32257639 hsa-mir-196a Coronary Artery Disease In particular, hsa-miR-196a-5p and hsa-miR-196b-5p may be more reliably associated with CAD. CONCLUSIONS: Between EAT and SAT in CAD patients, a total of 89 DEGs, and 10 key genes, including HOXA5, HOXB5, HOXC6, HOXC8, HOXB7, COL1A1, CCND1, CCL2, HP and TWIST1, and miRNAs hsa-miR-196a-5p and hsa-miR-196b-5p were predicted to play essential roles in CAD pathogenesis. +genetics_knock down_promote 32257391 hsa-mir-21 Reperfusion Injury, Renal Ischemia We found that GAS5, noticeably upregulated by renal I/R injury, was further suppressed by delayed IPC while knockdown of miR-21 in vivo before IPC could significantly increased the GAS5 levels. This study suggested that GAS5 facilitated apoptosis by competitively sponging miR-21, which negatively regulated TSP-1 in renal I/R injury. +genetics_GWAS 32257191 hsa-mir-146a Multiple Sclerosis It was previously demonstrated that miR-155 and miR-146a served a vital role in the pathophysiology of MS, and single nucleotide polymorphisms in miR-155 and miR-146a were found to be associated with the susceptibility to different autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and type I diabetes. +genetics_GWAS 32257191 hsa-mir-155 Multiple Sclerosis It was previously demonstrated that miR-155 and miR-146a served a vital role in the pathophysiology of MS, and single nucleotide polymorphisms in miR-155 and miR-146a were found to be associated with the susceptibility to different autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and type I diabetes. +transcription factor target 32256960 hsa-mir-338 Glioma 5p regulation of Hedgehog signaling. +lncRNA target 32256945 hsa-mir-451 Reperfusion Injury We provide the evidence that endogenous lncRNA Hotair is an essential negative regulator for oxidative stress and cardiac myocyte apoptosis in myocardial I/R injury, which is dependent on AMPKalpha activation via the EZH2/miR-451/Cab39 axis. +lncRNA target 32256824 hsa-mir-21 Uterine Cervical Neoplasms These results demonstrated that miR-21 was upregulated in cervical cancer tissues and promoted cell metastasis through modulating EMT. +genetics_overexpression_promote 32256821 hsa-mir-92a Carcinoma, Renal Cell The results demonstrated that miR-92a-3p overexpression significantly promoted RCC cell proliferation and colony formation. +genetics_overexpression_promote 32256819 hsa-mir-20 Breast Neoplasms Overexpression of miR-320 inhibited cell proliferation, migration and invasion via inhibition of the epithelial-mesenchymal transition and the PI3K/AKT signaling pathway in BC cells. +genetics_overexpression_suppress 32256813 hsa-mir-132 Liver Neoplasms Overexpression of miR3p resulted in significant inhibition of proliferation and induction of apoptosis in LC cells. +lncRNA target 32256808 hsa-mir-144 Esophageal Neoplasms To conclude, the present study demonstrated that miR-144 inhibits proliferation and invasion in esophageal cancer by directly targeting TIGAR. +transcription factor target 32256796 hsa-mir-613 Esophageal Squamous Cell Carcinoma In conclusion, the aforementioned results suggest that miR-613 targets G6PD to suppress ESCC cell migration and invasion through reduced MMP2 and MMP9 expression and inactivation of the STAT3 signaling pathway. +lncRNA target 32256788 hsa-mir-4458 Hemangioma MicroRNA-4458 (miR-4458) has been reported to function as a tumor suppressor in multiple malignancies, but its biological function in HAs remains unknown. Taken together, the results revealed that miR-4458 targeting of IGF1R may serve as a novel therapeutic strategy for treating patients with HAs. +genetics_overexpression_promote 32256758 hsa-mir-96 Cholangiocarcinoma Overexpression of miR-96 in vitro promoted CCA cell proliferation, migration and invasion. +genetics_knock down_suppress 32256756 hsa-mir-200b Breast Neoplasms miR-200b-knockdown and radixin overexpression were associated with enhanced cell invasion in breast cancer. +genetics_knock down_promote 32256737 hsa-mir-93 Nasopharyngeal Carcinoma Overexpression of PDCD4 significantly eliminated the promoting effects of miR-93 overexpression on NPC cell proliferation. +lncRNA target 32256733 hsa-mir-218 Colorectal Neoplasms Furthermore, reverse transcription-quantitative PCR revealed that miR-218 was downregulated in colorectal cancer tissues compared with paired adjacent healthy tissues. Taken together, the present results identified that the CCAT1/miR-218 axis serves a key role in the regulation of colorectal cancer progression, which may be used as potential therapeutic target for the treatment of colorectal cancer. +lncRNA target 32256731 hsa-mir-449b Carcinoma, Non-Small-Cell Lung In conclusion, the data from the present study demonstrated that IL-6 is targeted by miR-449b-3p, which affects the JAK2/STAT3 signaling pathway, impacting on the development of NSCLC. +circulation_biomarker_diagnosis_up 32256723 hsa-mir-24 Coronary Disease 3p in the peripheral blood of patients with CHD was significantly upregulated compared with that in healthy controls. +circulation_biomarker_diagnosis_ns 32256526 hsa-let-7g Stomach Neoplasms In conclusion, serum exosomal miR-92b-3p, -146b-5p, +circulation_biomarker_diagnosis_ns 32256526 hsa-mir-92b Stomach Neoplasms In conclusion, serum exosomal miR-92b-3p, -146b-5p, +genetics_overexpression_suppress 32256450 hsa-mir-21 Thyroid Neoplasms Moreover, overexpression of miR +genetics_overexpression_suppress 32256450 hsa-mir-183 Thyroid Neoplasms Moreover, overexpression of miR +genetics_knock down_promote 32256212 hsa-mir-125a Colorectal Neoplasms CONCLUSION: Our studies disclosed that circVAPA knockdown suppressed CRC cells cycle progression, migration, invasion and glycolysis partly by modulating miR-125a/CREB5 axis, suggesting a potential therapeutic strategy for CRC treatment. +genetics_overexpression_promote 32256208 hsa-mir-122 Osteosarcoma 5p-induced inhibition of cell proliferation, migration, and invasion was reversed by overexpression of ADAM10 in osteosarcoma cells. +genetics_overexpression_suppress 32256207 hsa-mir-122 Carcinoma, Pancreatic Ductal CONCLUSION: Overexpression of miR +lncRNA target 32256108 hsa-mir-200a Adenocarcinoma of Lung CONCLUSION: In summary, this study revealed that lncRNA-ATB is dramatically up-regulated in cisplatin-resistant LUAD cell lines, and that lncRNA-ATB facilitates cell survival by targeting the miR-200a/beta-catenin pathway in these cells. +genetics_overexpression_promote 32256087 hsa-mir-145 Uterine Cervical Neoplasms 5p overexpression or KLF5 silencing on the proliferation, migration and invasion of CC cells. +genetics_knock down_promote 32256086 hsa-mir-335 Gallbladder Neoplasms Loss of microRNA (miR)-335 expression may be a useful predictor of clinical outcomes and the reversal of its loss of expression may be a useful treatment strategy for GBC. +genetics_knock down_suppress 32256083 hsa-mir-139 Prostatic Neoplasms CONCLUSION: Knockdown of lncRNA TUG1 enhanced radiosensitivity in PCa via the TUG1/miR +other 32255668 hsa-mir-223 Pneumonia hsa-miR3p was a key regulator of the TLR and Th17 pathways in the sputum of subjects with asthma.Conclusions: This study of sputum microRNA and mRNA expression from patients with asthma demonstrates the existence of microRNA networks and genes that are associated with features of asthma severity. +other 32255668 hsa-mir-223 Asthma hsa-miR3p was a key regulator of the TLR and Th17 pathways in the sputum of subjects with asthma.Conclusions: This study of sputum microRNA and mRNA expression from patients with asthma demonstrates the existence of microRNA networks and genes that are associated with features of asthma severity. +lncRNA target 32255569 hsa-mir-129 Cardiomyopathies 5p/SOCS2 axis is a potential therapeutic target for alleviating myocardial injury in AMI patients after reperfusion. +genetics_overexpression_promote 32255479 hsa-mir-326 late onset Parkinson's disease Silencing of lncRNA 6030408B16RIK and WISP2 or overexpression of miR +genetics_overexpression_promote 32255479 hsa-mir-326 Uremia Silencing of lncRNA 6030408B16RIK and WISP2 or overexpression of miR +lncRNA target 32255479 hsa-mir-326 Renal Insufficiency In summary, lncRNA 6030408B16RIK silencing exerts an anti-fibrotic effect on uremic PD rats with ultrafiltration failure by inactivating the WISP2-dependent Wnt/beta-catenin pathway via miR +circulation_biomarker_prognosis_down 32255309 hsa-mir-34a Spinal Cord Injuries CONCLUSIONS: Measuring serum expression level of miR-34a over time may be used in tracking the process and neurological remission of TSCI. +transcription factor target 32255303 hsa-mir-182 Melanoma CONCLUSIONS: These findings demonstrated that miR-182 inhibited malignant melanoma cell proliferation via RECK, providing a novel target for the molecular treatment of malignant melanoma. +circulation_biomarker_diagnosis_ns 32255289 hsa-mir-101 Squamous Cell Carcinoma of Head and Neck Also, serum levels of miR-101a were lower in HNSCC patients. +genetics_GWAS 32255285 hsa-mir-146a Stomach Neoplasms CONCLUSIONS: Based on our meta-analysis, the microRNA-146a polymorphism is unlikely to be a risk factor for gastric cancer in overall population. +transcription factor target 32255115 hsa-mir-21 Breast Neoplasms As a proof of principle, miR-21, miR-27a and miR-375 were chosen as model targets because of their high expressions in breast cancer cells (MCF-7). +transcription factor target 32255115 hsa-mir-27a Breast Neoplasms As a proof of principle, miR-21, miR-27a and miR-375 were chosen as model targets because of their high expressions in breast cancer cells (MCF-7). +transcription factor target 32255115 hsa-mir-375 Breast Neoplasms As a proof of principle, miR-21, miR-27a and miR-375 were chosen as model targets because of their high expressions in breast cancer cells (MCF-7). +circulation_biomarker_diagnosis_up 32253819 hsa-mir-21 Heart Failure, Systolic 5p in the CS, compared with the peripheral venous circulation. +circulation_biomarker_diagnosis_up 32253819 hsa-mir-125b Heart Failure, Systolic 5p in the CS, compared with the peripheral venous circulation. +circulation_biomarker_diagnosis_up 32253819 hsa-mir-92 Heart Failure, Systolic 5p in the CS, compared with the peripheral venous circulation. +circulation_biomarker_diagnosis_up 32253621 hsa-mir-140 Osteoporosis Higher miR140-3p level and lower PTEN level were found in PBMCs of OP group compared to control group; there was a negative correlation between them in the serum of OP group. +lncRNA target 32253249 hsa-mir-147 Mycobacterium Infections, Nontuberculous This suggests that miR-147 and miR-148 share converged downstream pathways in response to mycobacterial infection, which was supported by data indicating that miR-147 upregulation inhibits the Toll-like receptor 4/NF-kappaB pathway. +lncRNA target 32253249 hsa-mir-148 Mycobacterium Infections, Nontuberculous This suggests that miR-147 and miR-148 share converged downstream pathways in response to mycobacterial infection, which was supported by data indicating that miR-147 upregulation inhibits the Toll-like receptor 4/NF-kappaB pathway. +lncRNA target 32253249 hsa-mir-148a Mycobacterium Infections, Nontuberculous This suggests that miR-147 and miR-148 share converged downstream pathways in response to mycobacterial infection, which was supported by data indicating that miR-147 upregulation inhibits the Toll-like receptor 4/NF-kappaB pathway. +other 32253156 hsa-mir-543 Diabetes Mellitus, Type 2 miR-543 may become a new marker to bring forth innovation in individualized treatment of diabetes. +lncRNA target 32252875 hsa-mir-99b Melanoma Of note, microRNA (miR) profiling showed that miR-99b-3p that was predicted to target the 3-untranslated region (3-UTR) of the CYLD mRNA was reduced in melanoma cell lines with high levels of CYLD compared with melanocyte lines. +lncRNA target 32252875 hsa-mir-99b Squamous Cell Carcinoma of Head and Neck Of note, microRNA (miR) profiling showed that miR-99b-3p that was predicted to target the 3-untranslated region (3-UTR) of the CYLD mRNA was reduced in melanoma cell lines with high levels of CYLD compared with melanocyte lines. +lncRNA target 32252802 hsa-mir-940 Glioma CONCLUSIONS: Our findings indicate that CUL7 plays a significant role in promoting tumorigenesis via NF-kappaB activation and that it can be negatively regulated by miR +other 32252801 hsa-mir-1202 Osteoarthritis Furthermore, KCNQ1OT1-has-miRETS1 might be vital for the process of OA. +other 32252678 hsa-mir-539 Carcinoma, Hepatocellular 5p, thus promoting the progression of HCC. +genetics_knock down_promote 32252553 hsa-mir-199a Spinal Cord Injuries Our results demonstrated that transplantation of sh-miR-199a-5p-modified OECs promoted functional recovery in SCI rats, suggesting that miR-199a-5p knockdown was more beneficial to the therapeutic effects of OEC transplants. +lncRNA target 32252341 hsa-mir-154 Alveolar Bone Loss CONCLUSION: Our results suggest that down-regulation of miR-154 in postnatal lung may function as an important physiological switch that permits the induction of the correct alveolar developmental program, while conversely, failure to down-regulate miR-154 suppresses alveolarization, leading to the common clinically observed phenotype of alveolar simplification. +other 32252341 hsa-mir-154 Vision, Low Maintenance of miR-154 expression in the postnatal distal lung epithelium under normoxia conditions is sufficient to reproduce the hypoalveologenesis phenotype triggered by hyperoxia. +transcription factor target 32252024 hsa-mir-188 Fatty Liver Taken together, our findings reveal a new regulatory role of miR-188 in glucose and lipid metabolism through the autophagy pathway, and provide a therapeutic insight for NAFLD. +lncRNA target 32251872 hsa-mir-125b Alzheimer Disease CONCLUSION: miR-34a-5p and miR-125b-5p inhibited Abeta-induced neurotoxicity by decreasing apoptosis and oxidative stress via targeting BACE1, providing novel targets for treatment of AD. +lncRNA target 32251872 hsa-mir-34a Alzheimer Disease CONCLUSION: miR-34a-5p and miR-125b-5p inhibited Abeta-induced neurotoxicity by decreasing apoptosis and oxidative stress via targeting BACE1, providing novel targets for treatment of AD. +other 32251781 hsa-mir-133a Encephalocele This study aims to assess the therapeutic capability of antagomiR-133a delivery from collagen-nanohydroxyapatite (coll-nHA) scaffolds following cell-free implantation in rat calvarial defects (7 mm diameter). +lncRNA target 32251712 hsa-mir-133a Obesity UCP2, IL18, and miR-133a-3p are dysregulated in subcutaneous adipose tissue of patients with obesity. In conclusion, UCP2 and miR-133a-3p expressions are downregulated in patients with obesity, while IL18 is upregulated. +circRNA target 32251633 hsa-mir-142 Alzheimer Disease CONCLUSION: Our current study suggested that berberine protected HN cell from Abeta42-induced neuronal damage at least partly through regulating the circHDAC9/miR5p axis, highlighting novel evidence for the neuroprotective effect of berberine in AD. +lncRNA target 32251605 hsa-mir-362 Carcinoma, Hepatocellular Conclusion: FENDRR inhibited HCC cells viability yet promoted apoptosis by targeting miR +other 32250744 hsa-mir-150 Pre-Eclampsia 5p was up-regulated in the placenta of patients with preeclampsia. +other 32250737 hsa-mir-149 Pre-Eclampsia 5p on these clinicopathological parameters of PE patients was opposite to that of DLX6-AS1, while ERP44 had the same effect as DLX6-AS1. +genetics_overexpression_suppress 32250192 hsa-mir-195 Stomach Neoplasms Our findings suggest that overexpression of sCLU induced chemoresistance in gastric cancer cells by downregulating miR +genetics_GWAS 32249954 hsa-mir-34 CREST Syndrome RESULTS: A number of genes, miRs, biological processes, and pathways were identified during mucociliary differentiation of both CRSwNP and control-NM epithelia, and notably, we have demonstrated for the first time that genetic transcriptional program responsible of ciliogenesis and cilia function is significantly impaired in CRSwNP epithelium, presumably produced by an altered expression of microRNAs, particularly of those miRs belonging to mir-34 and mi-449 families. +lncRNA target 32249539 hsa-mir-526b Osteosarcoma Through a transwell assay, we found that miR-526b suppressed OS cells metastasis by targeting of FOXC2. +other 32249364 hsa-mir-590 Prostatic Neoplasms The miRNA miR3p interferes with NOL6 expression making it a potential treatment for prostate cancer. +lncRNA target 32249206 hsa-mir-219a Reperfusion Injury, Cerebral Ischemia Upregulation of miR-219a-5p decreases cerebral ischemia/reperfusion injury by targeting Pde4d in vitro. +other 32248974 hsa-mir-489 Colorectal Neoplasms Mechanically, LEF1-AS1 functioned as competing endogenous RNA (ceRNA) for miR-489 to positively recover DIAPH1, thus playing an oncogenic role in CRC pathogenesis. +lncRNA target 32248969 hsa-mir-106b Osteosarcoma LMCD1-AS1 modulated survival of osteosarcoma via targeting miR-106b-5p. +lncRNA target 32248836 hsa-mir-338 Adenocarcinoma of Lung 3p, which in turn upregulated the expression of the downstream target RAB14 and affected the proliferation, migration and apoptosis of lung adenocarcinoma cells. +other 32248648 hsa-mir-577 Prostatic Neoplasms All the results above explained that SNHG3 accelerated prostate cancer progression by sponging miR-577 to up-regulate SMURF1 expression, suggesting that SNHG3 may act as a biomarker for prostate cancer patients. +lncRNA target 32248643 hsa-mir-34a Lung Neoplasms However, the underlying mechanism of HOTAIR regulation especially in association with miR-34a-5p in non-small-cell lung cancer (NSCLC) has not been explored. Collectively, this is the first report demonstrating reciprocal interaction of miR-34a-5p- and HOTAIR-mediated regulation of snail resulting in inhibition of EMT process by the combination of berberine and gefitinib suggesting that regulation of miR-34a-5p- and HOTAIR-mediated inhibition of EMT may provide novel treatment paradigms for lung cancer. +other 32248600 hsa-mir-214 Mesothelioma, Malignant These results indicate that miR-199/214 may affect the aggressive biological behavior of SM. +other 32248600 hsa-mir-199 Mesothelioma, Malignant These results indicate that miR-199/214 may affect the aggressive biological behavior of SM. +other 32248435 hsa-mir-9 Subarachnoid Hemorrhage 5p are elevated in the CSF following SAH and this elevation is associated with a poor functional outcome. +genetics_knock down_promote 32248399 hsa-mir-154 Neuralgia In conclusion, our study demonstrated that SNHG5 knockdown alleviated neuropathic pain and inhibited the activation of astrocytes and microglia by targeting the miR5p/CXCL13 axis, which might be a novel therapeutic target for neuropathic treatment clinically. +genetics_overexpression_promote 32248369 hsa-mir-223 Stomach Neoplasms 5p overexpression downregulated TP73-AS1 in gastric cancer cells. +lncRNA target 32248331 hsa-mir-106b Osteoarthritis Together, these observations demonstrated that the lncRNA H19 may promote chondrocyte proliferation and migration and inhibit matrix degradation in OA possibly by targeting the miR-106b-5p/TIMP2 axis. +transcription factor target 32248286 hsa-mir-155 Osteoporosis Inhibition of MiR-155 may provide a new therapeutic method for the prevention and treatment of diabetic osteoporosis. +other 32248204 hsa-mir-204 Breast Neoplasms CONCLUSIONS Overall, our results indicated that miR-204/ZWINT/cell cycle process might play an important role in breast cancer progression. +lncRNA target 32247616 hsa-mir-588 Spinal Cord Injuries In conclusion, circ-HIPK3 relieves the neuronal cell apoptosis through regulating miR-588/DPYSL5 axis in SCI. +transcription factor target 32247615 hsa-mir-150 Respiratory Distress Syndrome The study demonstrated that the suppression of miR-150 facilitated the translation of MTCH2 gene and MTCH2-regulated mitochondria transfer from BMSCs to RAW264.7 cells, suggested that miRmediated BMSCs has therapeutic potential for ARDS. +genetics_knock down_promote 32247266 hsa-mir-141 Osteoarthritis 3p sponge to promote BCL2L13 expression, suggesting that knockdown of SNHG15 expression in chondrocytes can be a potential therapeutic strategy to ameliorate OA progression. +lncRNA target 32246981 hsa-mir-212 Nervous System Diseases Taken together, miR3p could restrain early neurogenesis through the blockade of AKT/mTOR pathway activation by targeting MeCP2, suggesting a promising therapeutic target for neurogenic disorders. +lncRNA target 32246957 hsa-mir-345 Breast Neoplasms In the aggregate, our data suggest that the tumor microenvironment, which controls breast cancer spreading via miR345-regulated KISS1 expression, might modulate metastatic spreading by a mechanism(s) involving upregulation of E-cadherin production. +lncRNA target 32246902 hsa-mir-106b Carcinoma, Non-Small-Cell Lung miR-106b-5p enhanced NSCLC cell growth by downregulating cryptochrome 2 (CRY2), thereby increasing c-Myc expression. We identified numerous lncRNAs with dysregulated expression in NSCLC and demonstrated a novel oncogenic axis involving LINC01234, HNRNPA2B1, miR-106b-5p, CRY2, and c-Myc. +transcription factor target 32246873 hsa-mir-17 Colonic Neoplasms CONCLUSIONS: ZNF750 is negatively regulated by miR5p and inhibits the progression of colonic cancer. +lncRNA target 32246794 hsa-mir-150 Pregnancy Complications Taken conjointly, the upregulation of MALAT1 can reduce the expression of ET-1 by competitively binding to miR5p, which enhances the expression of ETBR via the activation of the NF-kappaB pathway in SMCs, thus exacerbating the hypertensive symptoms in the RUPP-induced rat models. +other 32246643 hsa-mir-142 Myocardial Ischemia 3p also participates in cerebral ischemia/reperfusion injury. +other 32246643 hsa-mir-142 Brain Ischemia 3p also participates in cerebral ischemia/reperfusion injury. +other 32246100 hsa-mir-208 ST Elevation Myocardial Infarction Importantly, this was observed in patients presenting early with STEMI, even before the markers of myocardial necrosis (cardiac troponin I, miR-208 and miR-499) were elevated, which suggests that the origin of miR-331 and miR3p might be in the VP. +other 32246100 hsa-mir-31 ST Elevation Myocardial Infarction 3p might be in the VP. +other 32246100 hsa-mir-151 ST Elevation Myocardial Infarction 3p might be in the VP. +other 32245323 hsa-mir-181b Autism Spectrum Disorde changes regardless of the direction) of miR-181b were significant in autistic children. +other 32245323 hsa-mir-23a Autism Spectrum Disorde On the other hand, miR-23a was upregulated and BCL-2 downregulated in ASD patients but the changes were not significant. +other 32245321 hsa-mir-126 Coronary Disease Expression levels of miR-1, miR-133, miR-208a, miR-206, miR-17, miR-29, miR-223, miR-326, and miR-155 as considerable indicators of inflammatory function significantly increased in SCF patients while the expression levels of miR-15a, miR-21, miR-25, miR-126, miR-17, miR-16 and miR-18a as considerable indicators of anti-inflammatory function significantly decreased in patients with SCF compared to the control group. +other 32245321 hsa-mir-208a Coronary Disease Expression levels of miR-1, miR-133, miR-208a, miR-206, miR-17, miR-29, miR-223, miR-326, and miR-155 as considerable indicators of inflammatory function significantly increased in SCF patients while the expression levels of miR-15a, miR-21, miR-25, miR-126, miR-17, miR-16 and miR-18a as considerable indicators of anti-inflammatory function significantly decreased in patients with SCF compared to the control group. +other 32245321 hsa-mir-133 Coronary Disease Expression levels of miR-1, miR-133, miR-208a, miR-206, miR-17, miR-29, miR-223, miR-326, and miR-155 as considerable indicators of inflammatory function significantly increased in SCF patients while the expression levels of miR-15a, miR-21, miR-25, miR-126, miR-17, miR-16 and miR-18a as considerable indicators of anti-inflammatory function significantly decreased in patients with SCF compared to the control group. +other 32245321 hsa-mir-16 Coronary Disease Expression levels of miR-1, miR-133, miR-208a, miR-206, miR-17, miR-29, miR-223, miR-326, and miR-155 as considerable indicators of inflammatory function significantly increased in SCF patients while the expression levels of miR-15a, miR-21, miR-25, miR-126, miR-17, miR-16 and miR-18a as considerable indicators of anti-inflammatory function significantly decreased in patients with SCF compared to the control group. +other 32245321 hsa-mir-18a Coronary Disease Expression levels of miR-1, miR-133, miR-208a, miR-206, miR-17, miR-29, miR-223, miR-326, and miR-155 as considerable indicators of inflammatory function significantly increased in SCF patients while the expression levels of miR-15a, miR-21, miR-25, miR-126, miR-17, miR-16 and miR-18a as considerable indicators of anti-inflammatory function significantly decreased in patients with SCF compared to the control group. +other 32245321 hsa-mir-223 Coronary Disease Expression levels of miR-1, miR-133, miR-208a, miR-206, miR-17, miR-29, miR-223, miR-326, and miR-155 as considerable indicators of inflammatory function significantly increased in SCF patients while the expression levels of miR-15a, miR-21, miR-25, miR-126, miR-17, miR-16 and miR-18a as considerable indicators of anti-inflammatory function significantly decreased in patients with SCF compared to the control group. +other 32245321 hsa-mir-155 Coronary Disease Expression levels of miR-1, miR-133, miR-208a, miR-206, miR-17, miR-29, miR-223, miR-326, and miR-155 as considerable indicators of inflammatory function significantly increased in SCF patients while the expression levels of miR-15a, miR-21, miR-25, miR-126, miR-17, miR-16 and miR-18a as considerable indicators of anti-inflammatory function significantly decreased in patients with SCF compared to the control group. +other 32245321 hsa-mir-326 Coronary Disease Expression levels of miR-1, miR-133, miR-208a, miR-206, miR-17, miR-29, miR-223, miR-326, and miR-155 as considerable indicators of inflammatory function significantly increased in SCF patients while the expression levels of miR-15a, miR-21, miR-25, miR-126, miR-17, miR-16 and miR-18a as considerable indicators of anti-inflammatory function significantly decreased in patients with SCF compared to the control group. +other 32245321 hsa-mir-206 Coronary Disease Expression levels of miR-1, miR-133, miR-208a, miR-206, miR-17, miR-29, miR-223, miR-326, and miR-155 as considerable indicators of inflammatory function significantly increased in SCF patients while the expression levels of miR-15a, miR-21, miR-25, miR-126, miR-17, miR-16 and miR-18a as considerable indicators of anti-inflammatory function significantly decreased in patients with SCF compared to the control group. +other 32245321 hsa-mir-1 Coronary Disease Expression levels of miR-1, miR-133, miR-208a, miR-206, miR-17, miR-29, miR-223, miR-326, and miR-155 as considerable indicators of inflammatory function significantly increased in SCF patients while the expression levels of miR-15a, miR-21, miR-25, miR-126, miR-17, miR-16 and miR-18a as considerable indicators of anti-inflammatory function significantly decreased in patients with SCF compared to the control group. +other 32245321 hsa-mir-25 Coronary Disease Expression levels of miR-1, miR-133, miR-208a, miR-206, miR-17, miR-29, miR-223, miR-326, and miR-155 as considerable indicators of inflammatory function significantly increased in SCF patients while the expression levels of miR-15a, miR-21, miR-25, miR-126, miR-17, miR-16 and miR-18a as considerable indicators of anti-inflammatory function significantly decreased in patients with SCF compared to the control group. +other 32245321 hsa-mir-29 Coronary Disease Expression levels of miR-1, miR-133, miR-208a, miR-206, miR-17, miR-29, miR-223, miR-326, and miR-155 as considerable indicators of inflammatory function significantly increased in SCF patients while the expression levels of miR-15a, miR-21, miR-25, miR-126, miR-17, miR-16 and miR-18a as considerable indicators of anti-inflammatory function significantly decreased in patients with SCF compared to the control group. +other 32245321 hsa-mir-17 Coronary Disease Expression levels of miR-1, miR-133, miR-208a, miR-206, miR-17, miR-29, miR-223, miR-326, and miR-155 as considerable indicators of inflammatory function significantly increased in SCF patients while the expression levels of miR-15a, miR-21, miR-25, miR-126, miR-17, miR-16 and miR-18a as considerable indicators of anti-inflammatory function significantly decreased in patients with SCF compared to the control group. +other 32245321 hsa-mir-15a Coronary Disease Expression levels of miR-1, miR-133, miR-208a, miR-206, miR-17, miR-29, miR-223, miR-326, and miR-155 as considerable indicators of inflammatory function significantly increased in SCF patients while the expression levels of miR-15a, miR-21, miR-25, miR-126, miR-17, miR-16 and miR-18a as considerable indicators of anti-inflammatory function significantly decreased in patients with SCF compared to the control group. +lncRNA target 32244901 hsa-mir-210 Fetal Hypoxia Thus, the present findings provide clear evidence that hypoxia alters CPC fate decisions and reveal a novel mechanism of microRNA-210 in the hypoxic effect, raising the possibility of microRNA-210 as a potential therapeutic target for heart disease. +lncRNA target 32244823 hsa-mir-629 Head and Neck Neoplasms 3p provides a mechanism of cisplatin resistance in head and neck cancer and may serve as a therapeutic target to reverse chemotherapy resistance. +other 32244558 hsa-mir-20b Diabetes, Gestational 3p, and miR-499a-5p. +other 32244558 hsa-mir-574 Diabetes Mellitus 3p represents a unique feature of aberrant expression profile of women with a prior exposure to GDM. +other 32244558 hsa-mir-20b Diabetes Mellitus 3p, and miR-499a-5p. +other 32244558 hsa-mir-1 Diabetes Mellitus 3p, and miR-499a-5p. +other 32244558 hsa-mir-126 Diabetes Mellitus 3p, and miR-499a-5p. +other 32244558 hsa-mir-125b Diabetes, Gestational 3p, and miR-499a-5p. +other 32244558 hsa-mir-100 Diabetes Mellitus 3p, and miR-499a-5p. +other 32244558 hsa-mir-143 Diabetes, Gestational 3p, and miR-499a-5p. +other 32244558 hsa-mir-100 Diabetes, Gestational 3p, and miR-499a-5p. +other 32244558 hsa-mir-574 Diabetes, Gestational 3p represents a unique feature of aberrant expression profile of women with a prior exposure to GDM. +other 32244558 hsa-mir-342 Diabetes, Gestational 3p represents a unique feature of aberrant expression profile of women with a prior exposure to GDM. +other 32244558 hsa-mir-125b Diabetes Mellitus 3p, and miR-499a-5p. +other 32244558 hsa-mir-499a Diabetes, Gestational 3p, and miR-499a-5p. +other 32244558 hsa-mir-143 Diabetes Mellitus 3p, and miR-499a-5p. +other 32244558 hsa-mir-29a Diabetes Mellitus 3p, and miR-499a-5p. +other 32244558 hsa-mir-499a Diabetes Mellitus 3p, and miR-499a-5p. +other 32244558 hsa-mir-20a Diabetes, Gestational 3p, and miR-499a-5p. +other 32244558 hsa-mir-20a Diabetes Mellitus 3p, and miR-499a-5p. +other 32244558 hsa-mir-133a Diabetes, Gestational 3p, and miR-499a-5p. +other 32244558 hsa-mir-130b Diabetes, Gestational 3p, and miR-499a-5p. +other 32244558 hsa-mir-195 Diabetes Mellitus 5p) that were induced by GDM-complicated pregnancy are long-acting and may predispose mothers affected with GDM to later development of diabetes mellitus and cardiovascular/cerebrovascular diseases. +other 32244558 hsa-mir-130b Diabetes Mellitus 3p, and miR-499a-5p. +other 32244558 hsa-mir-29a Diabetes, Gestational 3p, and miR-499a-5p. +other 32244558 hsa-mir-133a Diabetes Mellitus 3p, and miR-499a-5p. +other 32244558 hsa-mir-1 Diabetes, Gestational 3p, and miR-499a-5p. +other 32244558 hsa-mir-195 Diabetes, Gestational 5p) that were induced by GDM-complicated pregnancy are long-acting and may predispose mothers affected with GDM to later development of diabetes mellitus and cardiovascular/cerebrovascular diseases. +other 32244558 hsa-mir-16 Diabetes Mellitus 5p) that were induced by GDM-complicated pregnancy are long-acting and may predispose mothers affected with GDM to later development of diabetes mellitus and cardiovascular/cerebrovascular diseases. +other 32244558 hsa-mir-24 Diabetes Mellitus 3p represents a unique feature of aberrant expression profile of women with a prior exposure to GDM. +other 32244558 hsa-mir-24 Diabetes, Gestational 3p represents a unique feature of aberrant expression profile of women with a prior exposure to GDM. +other 32244558 hsa-mir-342 Diabetes Mellitus 3p represents a unique feature of aberrant expression profile of women with a prior exposure to GDM. +other 32244558 hsa-mir-126 Diabetes, Gestational 3p, and miR-499a-5p. +other 32244558 hsa-mir-17 Diabetes Mellitus 3p, and miR-499a-5p. +other 32244558 hsa-mir-17 Diabetes, Gestational 3p, and miR-499a-5p. +other 32244558 hsa-mir-16 Diabetes, Gestational 5p) that were induced by GDM-complicated pregnancy are long-acting and may predispose mothers affected with GDM to later development of diabetes mellitus and cardiovascular/cerebrovascular diseases. +circulation_biomarker_diagnosis_up 32244548 hsa-mir-1228 Colorectal Neoplasms miR3p, the top upregulated miRNA in CRC, was chosen to be validated on tissue and plasma samples, as it was demonstrated to be downregulated at tissue level in our patient cohort. +lncRNA target 32244500 hsa-mir-1285 Colorectal Neoplasms Altogether, our findings uncover a novel oncogenic microRNA in colorectal cancer and lay the foundation for further studies aiming at the development of possible therapeutic strategies based on miR-1285 targeting. +other 32244461 hsa-mir-124 Brain Injuries, Traumatic 3p in the perilesional cortex that might contribute to post-injury neurodegeneration and inflammation. +lncRNA target 32244197 hsa-mir-92a-2 Anorectal Malformations 5p potentially contribute to ARMs by inhibiting proliferation and enhancing apoptosis of intestinal cells via negatively regulating PRKCA/beta-catenin. +circulation_biomarker_diagnosis_ns 32244169 hsa-mir-181b Esophageal Neoplasms Moreover, miR-181b-5p was highly expressed in ESCC tissues and serum EVs. +lncRNA target 32243981 hsa-mir-361 Triple Negative Breast Neoplasms In-depth mechanistic studies highlighted that HA-TQ-Nps retarded cell migration of TNBC cells through up-regulation of microRNA-361 which in turn down-regulated Rac1 and RhoA mediated cell migration and also perturbed the cancer cell migration under the influence of the autocrine effect of VEGF-A. +genetics_knock down_promote 32243962 hsa-mir-424 Dihydropyrimidine Dehydrogenase Deficiency Knockdown of XIST suppressed DP cell activity, cell proliferation, ALP activity and the expression of other DP markers by sponging miR-424. +lncRNA target 32243922 hsa-mir-155 Acute Kidney Injury Dysregulated CCAT1/miR-155/SIRT1 pathway regulated disease progression in a murine model of LPS-induced AKI, and NF-kappaB pathway involved in. +lncRNA target 32243909 hsa-mir-384 Spinal Cord Injuries 5p promotes recovery of rats with SCI by suppressing autophagy via direct targeting of Beclin-1. +transcription factor target 32243691 hsa-mir-21 Fibrosis, Renal These results indicated that melatonin could alleviate TGF-beta1-induced renal FMT and UUO-induced renal fibrosis through down-regulation of miR +genetics_GWAS 32243354 hsa-mir-149 Glioma The above results demonstrated that miR-149 rs2292832 C/T polymorphism was a potential prognostic biomarker for glioma development by regulating miR-149/CDK6 axis. +lncRNA target 32243061 hsa-mir-24 Colonic Neoplasms In conclusion, hsa_circ_0079662, as a ceRNA binding with hsa-mir5p, can regulate target gene HOXA9 and induced the mechanism of chemotherapy drug oxaliplatin resistance in CRC through the TNF-alpha pathway in human colon cancer. +lncRNA target 32242897 hsa-mir-195 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma All in all, LINC00511 exacerbated T-ALL progression via miR +genetics_knock down_promote 32242402 hsa-mir-98 Inflammatory Bowel Diseases In conclusion, knockdown of miR +other 32242002 hsa-mir-495 Rhinitis, Allergic In conclusion, our findings indicated that the interactions among CircHIPK3, LncGAS5, and miR-495 play a critical role in the regulation of Th2 differentiation in AR. +other 32241689 hsa-mir-4286 Bipolar Disorder miR-4286 was also decreased in postmortem brains from 12 patients with BD who died by suicide compared to 13 controls, even though it did not reach statistical significance (FC=0.51, p = 0.07). +genetics_overexpression_promote 32240746 hsa-mir-1299 Osteosarcoma Overexpressing miR-1299 in OS cells decreased CDK6 expression and arrested OS cell growth and cell cycle progression. +other 32240720 hsa-mir-494 Macular Degeneration GENERAL SIGNIFICANCE: EV miR3p is a potential biomarker for RPE mitochondrial dysfunction, which plays a central role in non-neovascular age-related macular degeneration, and may be a diagnostic biomarker for monitoring the spread of degeneration to neighboring RPE cells in the retina. +other 32240720 hsa-mir-494 Mitochondrial Diseases GENERAL SIGNIFICANCE: EV miR3p is a potential biomarker for RPE mitochondrial dysfunction, which plays a central role in non-neovascular age-related macular degeneration, and may be a diagnostic biomarker for monitoring the spread of degeneration to neighboring RPE cells in the retina. +genetics_knock down_suppress 32240701 hsa-mir-155 Inflammation Knockdown or overexpression of miR +lncRNA target 32240501 hsa-let-7b Nociceptive Pain The present study aimed to explore the function of let-7b-5p in p38MAPK pathway and the development of EA tolerance in the inflammatory nociception. By upregulating the p38MAPK pathway through the inactivation of the MKP-1 gene, let-7b-5p contributes to EA tolerance in complete Freund's adjuvant (CFA)-induced inflammatory nociception rats. +lncRNA target 32239691 hsa-mir-744 Colorectal Neoplasms miR-744 was identified to be the tumor suppressor microRNA, which targeted RFC2 directly for inhibiting the proliferation of CRC cells both in vivo and in vitro. +genetics_overexpression_promote 32239627 hsa-mir-153 Reperfusion Injury 3p overexpression blocks the interaction between Bcl-2 and Beclin1 via down-regulation of Bcl-2 to promote autophagy of chondrocytes, thus protecting knee joint against IRI after TKA under sevoflurane preconditioning. +other 32239427 hsa-mir-1301 Colorectal Neoplasms 3p to elevate AKT1 levels in vitro and in vivo. +other 32239390 hsa-mir-125a Demyelinating Diseases Globally, our studies show that miR-125a-3p over-expression can alter signaling pathways and biological processes essential for myelin formation in oligodendrocytes, suggesting that alteration of miR-125a-3p levels may contribute to impairing oligodendrocyte maturation in demyelinating diseases. +lncRNA target 32239379 hsa-mir-4290 Stomach Neoplasms GC cells expressing sh-DLX6-AS1 showed significantly lower level of 3-phosphoinositide-dependent protein kinase 1 (PDK1), a target of miR-4290, compared to cells expressing control shRNA. CONCLUSIONS: LncRNA DLX6-AS1 regulated tumor growth and aerobic glycolysis in GC by targeting miR-4290 and PDK1, suggesting DLX6-AS1 might serve as a novel potential therapeutic target for GC treatment from bench to clinic. +other 32238921 hsa-mir-34a Neoplasms BACKGROUND: In this first-in-human, Phase 1 study of a microRNA-based cancer therapy, the recommended Phase 2 dose (RP2D) of MRX34, a liposomal mimic of microRNA-34a (miR-34a), was determined and evaluated in patients with advanced solid tumours. +genetics_overexpression_promote 32238705 hsa-mir-142 Glioma To elucidate the reason accounting for its overexpression, it is identified miR +epigenetics 32238162 hsa-mir-379 Mouth Neoplasms RESULTS: We demonstrated that deregulated miR-30a and miR-379 could represent a mechanism for the silencing of ADHFE1 and ALDH1A2 in OSCC through targeting DNMT3B. Ectopic expression of miR-30a and miR-379 could induce re-expression of methylation-silenced ADHFE1 and ALDH1A2, and lead to growth inhibition in oral cancer cells. +other 32237949 hsa-mir-27a Sepsis "miR-27a can promote sepsis by upregulating tumor necrosis factor-alpha (TNF-alpha). CONCLUSION: We conclude that TUG1 is downregulated in sepsis and may act as a molecular ""sponge"" of miR-27a to downregulate TNF-alpha." +circulation_biomarker_diagnosis_ns 32237936 hsa-mir-1251 Premature Birth RESULTS: Four maternal blood EBF1-based miRNA transcripts (MIR4266, MIR1251, MIR601, MIR3612) in the 3rd trimester were significantly associated with sPTB. +circulation_biomarker_diagnosis_ns 32237936 hsa-mir-4266 Premature Birth RESULTS: Four maternal blood EBF1-based miRNA transcripts (MIR4266, MIR1251, MIR601, MIR3612) in the 3rd trimester were significantly associated with sPTB. +circulation_biomarker_diagnosis_ns 32237936 hsa-mir-612 Premature Birth RESULTS: Four maternal blood EBF1-based miRNA transcripts (MIR4266, MIR1251, MIR601, MIR3612) in the 3rd trimester were significantly associated with sPTB. +circulation_biomarker_diagnosis_ns 32237936 hsa-mir-601 Premature Birth RESULTS: Four maternal blood EBF1-based miRNA transcripts (MIR4266, MIR1251, MIR601, MIR3612) in the 3rd trimester were significantly associated with sPTB. +genetics_overexpression_suppress 32237270 hsa-mir-455 Lung Hypoplasia In summary, the overexpression of miR +lncRNA target 32237066 hsa-mir-155 Adenocarcinoma of Lung 5p may suppress the expression of PD-L1 in LUAD. +circulation_biomarker_diagnosis_down 32237054 hsa-mir-495 Inflammation Here, we first found that miR-495 was downregulated in serum of patients with acute stage pneumonia. +lncRNA target 32236863 hsa-mir-424 Glioma The oncogenic lncRNA CCAT2 is highly associated with the development of glioma and exerts its function by upregulating VEGFA via miR-424. +lncRNA target 32236759 hsa-mir-199a Osteosarcoma CONCLUSIONS: Through molecular biology studies and rescue assays, we further demonstrated that EWS promotes tumor growth through the miR-199a-5p/Sox2 signaling axis in osteosarcoma. +lncRNA target 32236628 hsa-mir-378 Carcinoma, Hepatocellular Moreover, miR378 increased the rate of apoptosis and upregulated the expression of Bax and p53, and suppressed the cell cycle and downregulated the expression of Cyclin D1, Bcl2, Akt, betacatenin and Survivin much more effectively in the HCC cell line by applying the combined method. +other 32236623 hsa-mir-10b Carcinoma, Hepatocellular hsamiR10b5p, hsamiR10b3p, hsamiR2245p, hsamiR1835p and hsamiR1825p were considered as the optimal diagnostic biomarkers for hepatocellular carcinoma. Notably, hsamiR10b5p and hsamiR10b3p had a significant prognosis value for patients with hepatocellular carcinoma. +transcription factor target 32236614 hsa-mir-28 Carcinoma, Non-Small-Cell Lung Therefore, the miR28/PTEN axis may serve as a potential diagnostic and therapeutic target for NSCLC. +transcription factor target 32236592 hsa-mir-500a Colorectal Neoplasms Inhibition of miR500a5p resulted in spindlelike morphological changes and reorganization of Factin in CRC cells. +lncRNA target 32236583 hsa-mir-181b Osteosarcoma Targeting miR181b to inhibit its abnormal upregulation might be a potent strategy for OS treatment. +genetics_overexpression_promote 32236579 hsa-mir-21 Endometrial Neoplasms Using RTqPCR and western blotting, it was revealed that overexpressing miR215p significantly inhibited SOX17 protein expression in endometrial cancer cell lines. +genetics_knock down_promote 32236577 hsa-mir-1183 Carcinoma, Non-Small-Cell Lung Knockdown of circACACA impeded NSCLC progression by sponging miR1183 and inactivating the PI3K/PKB signaling pathway. +other 32236570 hsa-mir-132 Myocardial Reperfusion Injury The present study aimed to investigate the roles of miR132 in myocardial ischaemia/reperfusion (I/R) injury and the underlying mechanisms. +genetics_overexpression_promote 32236568 hsa-mir-539 Pancreatic Carcinoma Therefore, miR539 overexpression may contribute toward development of novel therapeutic strategies for PCa in the future. +transcription factor target 32236173 hsa-mir-33a Fluoride Poisoning Collectively, UA promoted the reverse cholesterol transport in macrophage-derived foam cells and interfered with cholesterol metabolism possibly through regulating the miRNA-33 expression and interaction with the ERK/AMPKalpha/SREBP1 signaling pathway. +transcription factor target 32236173 hsa-mir-3 Fluoride Poisoning Collectively, UA promoted the reverse cholesterol transport in macrophage-derived foam cells and interfered with cholesterol metabolism possibly through regulating the miRNA-33 expression and interaction with the ERK/AMPKalpha/SREBP1 signaling pathway. +lncRNA target 32235846 hsa-mir-148a Stomach Neoplasms Our search for miRNA target genes identified a total of 18 oncogenic targets of miR-148a-5p in GC cells. +circulation_biomarker_prognosis_ns 32234872 hsa-mir-204 Pancreatic Carcinoma 3p in serum exosomes were differentially expressed among intraductal papillary mucinous neoplasms, mucinous cystic neoplasms, and PC. +circulation_biomarker_prognosis_ns 32234872 hsa-mir-196b Pancreatic Carcinoma 3p in serum exosomes were differentially expressed among intraductal papillary mucinous neoplasms, mucinous cystic neoplasms, and PC. +lncRNA target 32234517 hsa-mir-148a Hypercholesterolemia PDE caused hypercholesterolemia in male adult offspring rats, which was mediated via dexamethasone activated intrauterine hepatic GR, enhanced the expression of DGCR8 and miR-148a, thereby reducing the expression of LDLR, leading to impaired liver cholesterol reverse transport function, and finally causing hypercholesterolemia in adult rats. +other 32234499 hsa-mir-1252 Thyroid Cancer, Papillary CONCLUSION: Our study uncovered the oncogenic contributions of hsa_circ_0011290-miRFSTL1 in PTCs. +other 32233998 hsa-mir-542 Osteosarcoma AIMS AND OBJECTIVE: This aim of the present study was to identify the key genes and explore novel insights into the molecular mechanism of miR3p over-expressed Osteosarcoma. +genetics_knock down_promote 32233984 hsa-mir-552 Laryngeal Neoplasms More importantly, the p53 siRNA or p53 overexpression virus abrogated the discrepancy of growth and metastasis capacity between miR-552 interference laryngocarcinoma cells and control cells. +other 32233818 hsa-mir-155 Virus Diseases Using quantitative real-time PCR, expression patterns for mir-155, pro-inflammatory TNFalpha and IL-8, transcription factor NF-kappaB1, and anti-inflammatory IL-4 were investigated 8, 12, and 18 h after virus activation. In conclusion, this study added evidence that mir-155 signaling represents a sensitive pathway to chemically-induced immunomodulation and indicated that PCBs can modulate highly-regulated innate immune system signaling pathways important in determining host immune response outcomes during viral infections. +circulation_biomarker_diagnosis_up 32233625 hsa-mir-21 Diabetes Mellitus, Type 2 RESULTS: We found that miR-21 antagomir reduced blood glucose concentration in T2DM rats. +circulation_biomarker_diagnosis_up 32233625 hsa-mir-21 Lipid Metabolism Disorders RESULTS: We found that miR-21 antagomir reduced blood glucose concentration in T2DM rats. +other 32233607 hsa-mir-22 Prostatic Neoplasms These results showed that MIR22HG could serve as a novel biomarker for prostate cancer. +transcription factor target 32233593 hsa-mir-223 Liver Neoplasms 3p regulates the occurrence and development of liver cancer cells by targeted down-regulating the expression of FAT1. +genetics_overexpression_promote 32233587 hsa-mir-139 Breast Neoplasms Conclusion: Overexpression of miR +exosome 32233440 hsa-mir-21 Diabetic Wound The miR5p mimics, as novel therapeutic candidates for diabetic wounds, were loaded into hASC-exos by electroporation, taking advantage of natural availability and biocompatibility of exosomes as extracellular miRNA transporting particles. +exosome 32233025 hsa-mir-29b Nerve Degeneration Consistently, miR-29b-3p was observed in exosomes isolated from long-term differentiated atrophic C2C12 cells. +other 32232523 hsa-mir-122 Liver Neoplasms Liver tumor-related miRNA-21, miRNA-122, and miRNA-222 could be simultaneously detected with LOD of 2 pM. +other 32232523 hsa-mir-222 Liver Neoplasms Liver tumor-related miRNA-21, miRNA-122, and miRNA-222 could be simultaneously detected with LOD of 2 pM. +other 32232523 hsa-mir-21 Liver Neoplasms Liver tumor-related miRNA-21, miRNA-122, and miRNA-222 could be simultaneously detected with LOD of 2 pM. +transcription factor target 32232409 hsa-mir-145 Uterine Cervical Neoplasms The present study is the first time to identify miR-145 as a candidate target in cervical cancer and show an association between miR-145 and pyroptosis, which provides a novel therapy for the treatment of cervical cancer. +circulation_biomarker_diagnosis_ns 32232409 hsa-mir-145 Necrobiotic Disorders After transfection of si-miR-145 plasmids, the effects of tanshinone II A on HeLa cells were converted, including cell proliferation, apoptosis and pyroptosis. The present study is the first time to identify miR-145 as a candidate target in cervical cancer and show an association between miR-145 and pyroptosis, which provides a novel therapy for the treatment of cervical cancer. +genetics_GWAS 32232000 hsa-mir-135b Stomach Neoplasms miR-135b-5p overexpression reduced chemoresistance and induced apoptosis in GC cells and attenuated ITGA2-induced chemoresistance and antiapoptotic effects by inhibiting MAPK signaling and EMT. In conclusion, this study underscored the role and mechanism of ITGA2 in GC and suggested the novel miR-135b-5p/ITGA2 axis as an epigenetic cause of chemoresistance with diagnostic and therapeutic implications. +genetics_knock down_promote 32231999 hsa-mir-1224 Colorectal Neoplasms Gain- and loss-of-function assays reveal that miR +circRNA target 32231744 hsa-mir-488 Squamous Cell Carcinoma of Head and Neck The increased TROP2 promotes tumor proliferation, therefore, providing evidence in support of targeting the circ-0000495/miR3p/TROP2 axis in contributing to HNSCC therapy and preventing tumor metastasis. +other 32231742 hsa-mir-222 Carcinoma, Non-Small-Cell Lung 5p/TAB2 were identified as potential ceRNA networks involved in drug resistance to NSCLC. +genetics_knock down_promote 32231737 hsa-mir-217 Carcinoma, Hepatocellular We found that knockdown of circMAN2B2 expression in the HCC cell lines Hep-G2 and Huh-7 significantly inhibited cell proliferation by sponging (miRNA) miR-217 and inhibiting its function. Through a series of experiments, we also demonstrated that miR-217 functioned as a tumor suppressor molecule in HCC cells and regulated the expression of mitogen-activated protein kinase 1 (MAPK1). +lncRNA target 32231727 hsa-mir-129-2 Cholangiocarcinoma 2-3p in ICC, and suggest that this miRNA may provide a potential target for the treatment of ICC. +circulation_biomarker_diagnosis_up 32231725 hsa-mir-204 Stomach Neoplasms 5p markedly decreased in GC patients' tissue and serum, especially in GC with lymphatic metastasis. +lncRNA target 32231562 hsa-mir-574 Lung Neoplasms 5p exhibits oncogenic properties and promotes lung tumor growth in vivo via induction of mPGES +lncRNA target 32231562 hsa-mir-574 Carcinoma, Non-Small-Cell Lung 5p/CUGBP1 regulation on mPGES-1 expression supports the therapeutic strategy of pharmacological inhibition of PGE(2) formation, which may provide significant therapeutic value for NSCLC patients with high miR +other 32231469 hsa-mir-138 Myocardial Infarction RESULTS: Clinical data of Gene Expression Omnibus (GEO) database indicated that LINC01614 was highly regulated in first acute myocardial infarction, whereas miR5p was downregulated in unstable angina pectoris. +genetics_overexpression_promote 32231464 hsa-mir-133a Thyroid Neoplasms Later, miR-133a-3p was searched as an upstream gene of LPAR3 and EGFR, and LPAR3 could partially rescue the suppressive effect of miR-133a-3p overexpression on TC progression, whereas the co-transfection of LPAR3 and EGFR completely restored the inhibition. Through restoration assays, we discovered that ZEB1-AS1 regulated LPAR3 and EGFR expression to mediate TC cell proliferation and apoptosis by sponging miR-133a-3p. +exosome 32231463 hsa-mir-21 Glioma BACKGROUND: Growing studies have focused on the role of microRNA-21 (miR-21) in glioma, thus our objective was to discuss the effect of M2 bone marrow-derived macrophage (BMDM)-derived exosomes (BMDM-Exos) shuffle miR-21 on biological functions of glioma cells by regulating paternally expressed gene 3 (PEG3). +transcription factor target 32231210 hsa-mir-4651 Gerodermia osteodysplastica These findings reveal a novel mechanism regulating DIGO progression and suggest the potential of miR-4651 and HMGA2 as therapeutic targets. +circulation_biomarker_diagnosis_up 32231021 hsa-mir-146a Prostatic Neoplasms Besides identifying several novel PC-associated dysregulated microRNAs in plasma, we confirmed the previously reported upregulation of miR-375 and downregulation of miR-146a-5p. +circulation_biomarker_diagnosis_up 32231021 hsa-mir-375 Prostatic Neoplasms Besides identifying several novel PC-associated dysregulated microRNAs in plasma, we confirmed the previously reported upregulation of miR-375 and downregulation of miR-146a-5p. +genetics_overexpression_suppress 32230799 hsa-mir-216a Breast Neoplasms In the present study, we identify miR-216a-5p as a downregulated microRNA in breast cancer stem cells vs. We demonstrate that overexpression of miR-216a-5p impairs stemness markers, mammosphere formation, ALDH activity, and the level of Toll-like receptor 4 (TLR4), which plays a significant role in breast cancer progression and metastasis by leading to the release of pro-inflammatory molecules, such as interleukin 6 (IL-6). +lncRNA target 32229697 hsa-mir-4716 Hashimoto Disease Further studies confirmed that NONHSAT079547.2 could promote cell growth and control IL-17 expression and secretion via the NONHSAT079547.2/miR5p/IL-17 axis.This is the first study to describe the lncRNA profile in CD4+ T cells of HT patients. +genetics_knock down_promote 32229685 hsa-mir-183 Esophageal Squamous Cell Carcinoma The effects of ELFN1-AS1 knockdown on ESCA progression were partially rescued by inhibition of miR +lncRNA target 32229486 hsa-mir-494 Esophageal Squamous Cell Carcinoma In conclusion, SBF2-AS1 contributed to cell proliferation, migration, invasion and EMT in ESCC by enhancing PFN2 expression via sponging miR-494, providing promising biomarkers for ESCC diagnosis and treatment. +lncRNA target 32229486 hsa-mir-494 Esophageal Neoplasms In conclusion, SBF2-AS1 contributed to cell proliferation, migration, invasion and EMT in ESCC by enhancing PFN2 expression via sponging miR-494, providing promising biomarkers for ESCC diagnosis and treatment. +genetics_overexpression_promote 32229339 hsa-mir-141 Osteoporosis CONCLUSION: Overexpression of miR-141 could inhibit the osteoporosis of jawbones in ovariectomized rats by activating the Wnt/beta-catenin pathway. +circRNA target 32228656 hsa-mir-614 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: circFOXM1promotes NSCLC progression by interacting with miR-614 and thus inactivating the function of miR-614, which will further release the suppression of FAM83D. circFOXM1/miR-614/FAM83D regulatory network may serve as a potential therapeutic target for NSCLC patients. +transcription factor target 32228643 hsa-mir-28 Hepatitis B 3p downregulated its target FOXO4, leading to the promotion of cell injury in HBV-infected liver cells THLE-2. +lncRNA target 32228617 hsa-mir-326 Hypoxia-Ischemia, Brain, Newborn Our findings indicated that inhibition of miR-326 may improve cell survival and decrease cell apoptosis in neonatal HIBD through the target gene DOR. +genetics_overexpression_promote 32228546 hsa-mir-142 Carcinoma, Non-Small-Cell Lung The effects of overexpressing MIR17HG, miR +lncRNA target 32228518 hsa-mir-653 Melanoma CONCLUSIONS: AFAP1-AS1 exerts its oncogenic function in melanoma by targeting miR +other 32228510 hsa-mir-9 Pancreatic Carcinoma Among the predicted features between HS and ML was the involvement of miRNA-9 in this switch. +other 32228467 hsa-mir-92a Venous Thrombosis miR-92a-3p and oxidative stress contributed to endothelial dysfunction and simultaneously was associated with CRT. +lncRNA target 32228440 hsa-mir-503 Intervertebral disc disease CONCLUSION: Our data suggested that the MALAT1-miRMAPK pathway plays a critical role in NPCs, which may be a potential strategy for alleviating IDD. +other 32228439 hsa-mir-133a Infertility Analysis of the mRNA-miRNA interaction network suggested that CD36 (miR-122, miR-200a, miR-141), TNFAIP6 (miR-141, miR-200a, miR-182), CYP11A1 (miR-122), SERPINA5 (miR-1, miR-206, miR-133a-3p, miR-133b), and PTGFR (miR-182, miR-122) might be related to fertility, but requires further research on follicular somatic cells. +other 32228439 hsa-mir-1 Infertility Analysis of the mRNA-miRNA interaction network suggested that CD36 (miR-122, miR-200a, miR-141), TNFAIP6 (miR-141, miR-200a, miR-182), CYP11A1 (miR-122), SERPINA5 (miR-1, miR-206, miR-133a-3p, miR-133b), and PTGFR (miR-182, miR-122) might be related to fertility, but requires further research on follicular somatic cells. +other 32228439 hsa-mir-200a Infertility Analysis of the mRNA-miRNA interaction network suggested that CD36 (miR-122, miR-200a, miR-141), TNFAIP6 (miR-141, miR-200a, miR-182), CYP11A1 (miR-122), SERPINA5 (miR-1, miR-206, miR-133a-3p, miR-133b), and PTGFR (miR-182, miR-122) might be related to fertility, but requires further research on follicular somatic cells. +other 32228439 hsa-mir-206 Infertility Analysis of the mRNA-miRNA interaction network suggested that CD36 (miR-122, miR-200a, miR-141), TNFAIP6 (miR-141, miR-200a, miR-182), CYP11A1 (miR-122), SERPINA5 (miR-1, miR-206, miR-133a-3p, miR-133b), and PTGFR (miR-182, miR-122) might be related to fertility, but requires further research on follicular somatic cells. +other 32228439 hsa-mir-141 Infertility Analysis of the mRNA-miRNA interaction network suggested that CD36 (miR-122, miR-200a, miR-141), TNFAIP6 (miR-141, miR-200a, miR-182), CYP11A1 (miR-122), SERPINA5 (miR-1, miR-206, miR-133a-3p, miR-133b), and PTGFR (miR-182, miR-122) might be related to fertility, but requires further research on follicular somatic cells. +other 32228439 hsa-mir-122 Infertility Analysis of the mRNA-miRNA interaction network suggested that CD36 (miR-122, miR-200a, miR-141), TNFAIP6 (miR-141, miR-200a, miR-182), CYP11A1 (miR-122), SERPINA5 (miR-1, miR-206, miR-133a-3p, miR-133b), and PTGFR (miR-182, miR-122) might be related to fertility, but requires further research on follicular somatic cells. +other 32228439 hsa-mir-182 Infertility Analysis of the mRNA-miRNA interaction network suggested that CD36 (miR-122, miR-200a, miR-141), TNFAIP6 (miR-141, miR-200a, miR-182), CYP11A1 (miR-122), SERPINA5 (miR-1, miR-206, miR-133a-3p, miR-133b), and PTGFR (miR-182, miR-122) might be related to fertility, but requires further research on follicular somatic cells. +transcription factor target 32228353 hsa-mir-155 Periodontal Diseases Collectively, we identified novel Akt2/JNK1/2/c-Jun and Akt2/miR5p/DET1/c-Jun signaling pathways that regulate macrophage polarization and highlight that Akt2 inhibition promotes M2 polarization of macrophages and can be a novel potential candidate in the treatment of periodontitis. +lncRNA target 32228308 hsa-mir-532 Lung Neoplasms 5p functioned as a cancer suppressor by negatively regulating CCR4 in LC cells, pointing to a potential protective mechanism of miR +other 32228257 hsa-mir-342 Glioma 3p have potential as noninvasive biomarkers for differentiating glioma from other intracranial diseases in dogs. +other 32228257 hsa-mir-15b Glioma CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that miR-15b and miR3p have potential as noninvasive biomarkers for differentiating glioma from other intracranial diseases in dogs. +genetics_overexpression_promote 32228202 hsa-mir-34c Carcinoma, Non-Small-Cell Lung Overexpression of miR-34c sensitized NSCLC cells to paclitaxel and cisplatin both in vitro and in vivo. +transcription factor target 32228197 hsa-mir-34a Vascular Diseases Taken together, these findings demonstrate that CO reduces cellular senescence and liver aging through the regulation of miR-34a and Sirt1. +genetics_GWAS 32227711 hsa-mir-143 Prostatic Neoplasms OBJECTIVE: To explore the correlation between the rs4705342 gene mutation in the promoter region of the miR-143/ miR-145 cluster and the risk of PCa in the Chinese Han population. CONCLUSIONS: The rs4705342 gene mutation in the promoter region of the miR-143/ miR-145 cluster is significantly associated with the pathogenesis of PCa in the Chinese Han population. +genetics_GWAS 32227711 hsa-mir-145 Prostatic Neoplasms OBJECTIVE: To explore the correlation between the rs4705342 gene mutation in the promoter region of the miR-143/ miR-145 cluster and the risk of PCa in the Chinese Han population. CONCLUSIONS: The rs4705342 gene mutation in the promoter region of the miR-143/ miR-145 cluster is significantly associated with the pathogenesis of PCa in the Chinese Han population. +lncRNA target 32227618 hsa-mir-200 Breast Neoplasms In conclusion, SIX-1 exerts its pro-metastatic role in BC through lncATB/miR-200s axis of EMT signalling pathway and could act as an important diagnostic marker as well as a significant therapeutic target for clinically advanced BC. +exosome 32227590 hsa-mir-218 Endometritis However, uterine inflammation altered the immunoregulatory mechanism of exosome miR-218. +lncRNA target 32227563 hsa-mir-152 Carcinoma, Non-Small-Cell Lung CCAT1 binds with miR-152, and the effect of si-CCAT1 in NSCLC cell proliferation, cell invasion and epithelial-mesenchymal transition was partially reversed by anti-miR-152. CONCLUSIONS: Long non-coding RNA CCAT1 regulates tumor cell proliferation and invasion in NSCLC through suppressing miR-152. +lncRNA target 32226532 hsa-mir-146a Pancreatic Carcinoma Functional studies indicated that miR-146a-5p suppressed PDAC cell proliferation and sensitized PDAC cells to GEM chemotherapy by targeting the 3'-untranslated region (3'-UTR) of TRAF6. +circulation_biomarker_diagnosis_ns 32226531 hsa-mir-378a Hyperlipidemias Conclusions: This study defines a novel pathway of E2F1-miR-378a-3p-SORT1-ApoB100 that controls levels of circulating VLDL/LDL cholesterol and triglycerides by modulating degradation and secretion of ApoB100, and suggests the use of miR-378a-3p as a potential therapeutic target for dyslipidemia. +genetics_overexpression_promote 32226522 hsa-mir-34a Esophageal Squamous Cell Carcinoma Overexpression of miR-34a-5p could inhibit proliferation, migration, invasion and EMT of ESCC cells. +genetics_knock down_promote 32226520 hsa-mir-200a Nasopharyngeal Carcinoma Finally, it was demonstrated that siMYH10 could reverse the effect of miR-200a inhibitor on NPC cell migration and invasion. Taken together, it can be concluded that MYH10 is lowly expressed in NPC compared with adjacent tissues, and the loss of MYH10 can promote the migration and invasion of NPC cells; Among the miR-200 family, miR-200a has the strongest regulatory effect on MYH10; MYH10 is a direct target gene of miR200a, and miR200a targets MYH10 to regulate the migration and invasion of NPC cells. +lncRNA target 32226492 hsa-mir-18a Carcinoma, Renal Cell Importantly, miRNA-18a could serve as a potential diagnostic biomarker and therapeutic targets for ccRCC patients. +circRNA target 32226441 hsa-mir-21 Pancreatitis In conclusion, CircZFP644 may play an important role in the pathogenesis of SAP through sponging miR3p. +lncRNA target 32226311 hsa-mir-335 Adenocarcinoma of Lung CONCLUSION: FTX played an oncogenic role in LUAD and contributed to cancer development via targeting miR +other 32226305 hsa-mir-6979 Fractures, Bone In summary, our data indicates that the lncRNA Rhno1/miR5p/BMP2 axis is a significant regulatory mechanism controlling osteoblast differentiation, and it may thus offer a novel therapeutic strategy for fracture healing. +lncRNA target 32226296 hsa-mir-532 Sarcopenia 3p contributed to the pathogenesis of sarcopenia through mediating BAK1 expression. +circulation_biomarker_diagnosis_ns 32226248 hsa-mir-24 Polycystic Ovary Syndrome The levels of miR-24 was significantly decreased in PCOS subjects (P = 0.00) compared to control. The study suggests that serum miR-24 analysis in PCOS patients could be of diagnostic value that can be used as a biomarker for PCOS. +transcription factor target 32224917 hsa-mir-518f Prostatic Neoplasms miR-518f-5p has been shown to modulate the expression of the metastasis suppressor CD9 in prostate cancer. +genetics_overexpression_suppress 32224917 hsa-mir-518f Breast Neoplasms miR-518f-5p was overexpressed in breast cancer cell lines that displayed significantly lower CD9 expression as well as less endogenous CD9 3'UTR activity, as assessed using qPCR and dual luciferase assays. +other 32224889 hsa-mir-34a Myelodysplastic Syndromes Differential expression analyses identified that many hematopoiesis-related miRNAs (e.g., miR-34a, miR-125a, and miR-150) were significantly increased in MDS and that miRNAs clustered on 14q32 were specifically increased in early MDS. +other 32224889 hsa-mir-150 Myelodysplastic Syndromes Differential expression analyses identified that many hematopoiesis-related miRNAs (e.g., miR-34a, miR-125a, and miR-150) were significantly increased in MDS and that miRNAs clustered on 14q32 were specifically increased in early MDS. +other 32224889 hsa-mir-125a Myelodysplastic Syndromes Differential expression analyses identified that many hematopoiesis-related miRNAs (e.g., miR-34a, miR-125a, and miR-150) were significantly increased in MDS and that miRNAs clustered on 14q32 were specifically increased in early MDS. +lncRNA target 32224524 hsa-mir-519a Carcinoma, Non-Small-Cell Lung CONCLUSIONS: MiR-519a functions as a tumor suppressor and inhibits tumor progression of NSCLC via targeting STAT3. +circRNA target 32224273 hsa-mir-149 Carcinoma, Endometrioid Taken these together, we suggested that hsa_circ_0061140 might act as an effective therapy to treat EC through functioning as a molecular sponge of miR5p. +genetics_overexpression_promote 32224271 hsa-mir-430 Heart Diseases Overexpression and suppression of miR-430a resulted in abnormal KV (Kupffer's vesicles) development and disordered in nodal-related expression with consequent cardiac laterality. Moreover, rescue experiments were performed and suggested that cardiac and KV defections, induced by overexpressing miR-430a, could be rescued by injecting Posqt mRNA. +genetics_overexpression_promote 32224271 hsa-mir-430a Heart Diseases Overexpression and suppression of miR-430a resulted in abnormal KV (Kupffer's vesicles) development and disordered in nodal-related expression with consequent cardiac laterality. Moreover, rescue experiments were performed and suggested that cardiac and KV defections, induced by overexpressing miR-430a, could be rescued by injecting Posqt mRNA. +lncRNA target 32224251 hsa-mir-142 Reperfusion Injury, Hepatic Ischemia 3p played a considerable part in adjusting HI/R injury by targeting MARCKS, and miR +genetics_overexpression_promote 32223957 hsa-mir-10b Osteosarcoma Overexpression of FAM46C could inhibit cell growth, invasion and migration in OS; furthermore, it also can enforced the miR-10b inhibitor-induced effects on cell behaviors of OS cells. +genetics_knock down_promote 32223925 hsa-mir-665 Retinoblastoma HMGB1 axis output attenuated the influence of the LINC00205 knockdown on RB cells. +transcription factor target 32223896 hsa-mir-128 Heart Failure In conclusion, we reveal that targeting mir128-3p mitigates myocardial insulin resistance, thereafter slowing down the progression of heart failure post-ischemia. +other 32223721 hsa-mir-126 Lung Neoplasms METHODS: FFPE samples of colorectal adenocarcinoma, squamous carcinoma of lung and cases of invasive breast carcinoma were used to evaluate COP and LNA methods for the demonstration of miR-126 and miR-205. +other 32223721 hsa-mir-205 Lung Neoplasms METHODS: FFPE samples of colorectal adenocarcinoma, squamous carcinoma of lung and cases of invasive breast carcinoma were used to evaluate COP and LNA methods for the demonstration of miR-126 and miR-205. +other 32223721 hsa-mir-205 Colorectal Neoplasms METHODS: FFPE samples of colorectal adenocarcinoma, squamous carcinoma of lung and cases of invasive breast carcinoma were used to evaluate COP and LNA methods for the demonstration of miR-126 and miR-205. +other 32223721 hsa-mir-205 Carcinoma, Ductal, Breast METHODS: FFPE samples of colorectal adenocarcinoma, squamous carcinoma of lung and cases of invasive breast carcinoma were used to evaluate COP and LNA methods for the demonstration of miR-126 and miR-205. +other 32223721 hsa-mir-21 Prostatic Neoplasms The demonstration of miR-21 by ISH in high and low expressing prostate cancer cell lines was also compared with qRT-PCR. miR-21 was successfully demonstrated in the prostate cancer samples by COP ISH and expression levels of the miRNA demonstrated in the cell lines corresponded with qRT-PCR. +other 32223721 hsa-mir-126 Colorectal Neoplasms METHODS: FFPE samples of colorectal adenocarcinoma, squamous carcinoma of lung and cases of invasive breast carcinoma were used to evaluate COP and LNA methods for the demonstration of miR-126 and miR-205. +other 32223721 hsa-mir-126 Carcinoma, Ductal, Breast METHODS: FFPE samples of colorectal adenocarcinoma, squamous carcinoma of lung and cases of invasive breast carcinoma were used to evaluate COP and LNA methods for the demonstration of miR-126 and miR-205. +circulation_biomarker_diagnosis_up 32223661 hsa-mir-146a Guillain-Barre Syndrome OBJECTIVE: To study correlations between expression of microRNA-146a (miR-146a) and immunoglobulin and inflammatory cytokines in serum of patients with Guillain-Barre syndrome (GBS). +circulation_biomarker_diagnosis_ns 32223462 hsa-mir-146a Arthritis, Rheumatoid Furthermore, the serum levels of IL-6 and TNF-alpha significantly reduced in these patients after 12 weeks M2000 therapy (both with p < .05).Conclusions: The present research results determined the part of molecular mechanisms of drug M2000 in RA treatment, based on the expression and function modification of miR-146a, IRAK1, TRAF6, NF-kappaB, IL-6 and TNF-alpha. +circulation_biomarker_diagnosis_up 32222724 hsa-mir-135a Hypertension Moreover, the plasma levels of hsa-miR +circulation_biomarker_diagnosis_up 32222724 hsa-mir-124 Hypertension Moreover, the plasma levels of hsa-miR +transcription factor target 32222649 hsa-mir-210 Pre-Eclampsia CONCLUSION: PE-complicated placentas are associated with upregulated lncZBTB39, which negatively regulates trophoblast invasion and migration, most likely by preserving the expression of THSD7A mRNA through sponging miR-210. +lncRNA target 32222493 hsa-mir-142 Inflammation To our knowledge, this is the first study to demonstrate the effect of the EZH2-HIF-1alpha interaction and miR-142 on peritoneal fibrosis and inflammation and to suggest EZH2 and miR-142 as potential targets for the treatment of peritoneal fibrosis in patients with PD. +lncRNA target 32222493 hsa-mir-142 Diabetic Nephropathies To our knowledge, this is the first study to demonstrate the effect of the EZH2-HIF-1alpha interaction and miR-142 on peritoneal fibrosis and inflammation and to suggest EZH2 and miR-142 as potential targets for the treatment of peritoneal fibrosis in patients with PD. +epigenetics 32222459 hsa-mir-124-2 Papillomavirus Infections DISCUSSION: FAM19A4/miR124-2 methylation analysis has a good triage performance on baseline screening samples, with a cross-sectional CIN3+ sensitivity and long-term triage-negative CIN3+ risk equalling cytology triage. +other 32222254 hsa-mir-15a Mastocytosis, Cutaneous MiR-320a, miR-15a-5p, miR5p, and miR-20a-5p showed similar results in combined SCM samples. +other 32222254 hsa-mir-19b Mastocytosis, Cutaneous RESULT(S): Out of 372 screened miRNAs, miR-19b-3p and let-7a-5p were detected consistently in all SCM and sperm samples. MiR-19b-3p showed the highest area under the receiver operating characteristic curve values between positive and negative outcomes, with lower abundance levels in both combined SCM and sperm samples associated with a positive pregnancy outcome. +other 32222254 hsa-mir-21 Mastocytosis, Cutaneous MiR-320a, miR-15a-5p, miR5p, and miR-20a-5p showed similar results in combined SCM samples. +other 32222254 hsa-let-7a Mastocytosis, Cutaneous RESULT(S): Out of 372 screened miRNAs, miR-19b-3p and let-7a-5p were detected consistently in all SCM and sperm samples. +other 32222254 hsa-mir-20a Mastocytosis, Cutaneous MiR-320a, miR-15a-5p, miR5p, and miR-20a-5p showed similar results in combined SCM samples. +genetics_overexpression_promote 32222154 hsa-mir-665 Small Cell Lung Carcinoma Up-regulation of miR-665 expression could promoted proliferation, S-phase fraction, invasion and migration ability of SCLC NCI-H1688 cells, but this promotion effect was also reversed by overexpression of LLGL1. +other 32222118 hsa-mir-623 Myocardial Infarction Our data suggested that in MI, HIF1A-AS2 upregulation was associated with miR-623, which promoted expression of tripartite motif containing 44 (TRIM44). +other 32222024 hsa-mir-605 Carcinoma, Hepatocellular In conclusion, this research reveals the role of circFBXO11/miR-605/FOXO3/ABCB1 axis in the HCC OXA resistance, providing new insight for circRNA-based diagnostic and therapeutic strategies. +other 32221723 hsa-mir-21 Breast Neoplasms This nanoprobe allows us to acquire in vitro the determination of microRNA-21 in the range of 2-300 nM with a detection limit of 0.57 nM and the determination of Zn(2+) in the range 2-100 nM with a detection limit of 0.43 nM, and in situ simultaneous imaging in MCF-7 breast cancer cells. +lncRNA target 32221619 hsa-mir-195 Acute Lung Injury CONCLUSION: CASC9 protects lung epithelial cells from sepsis-induced injury via regulating miR +lncRNA target 32221619 hsa-mir-195 Sepsis CONCLUSION: CASC9 protects lung epithelial cells from sepsis-induced injury via regulating miR +other 32221502 hsa-mir-509 Carcinoma, Hepatocellular Mechanistically, LINC00467 performed as a sponge of microRNA (miR)3p and upregulated the expression of platelet-derived growth factor receptor alpha (PDGFRA) in HCC cells. +lncRNA target 32221048 hsa-mir-145 Colorectal Neoplasms 5p axis and FOXO1, MBNL1, MEF2C, RECK, PPM1E, TTLL7 and PCP4L1 were the seven potential downstream targets of hsa_circ_0000977/miR-135b-5p axis in CRC. +lncRNA target 32220970 hsa-mir-140 Carcinoma, Hepatocellular Moreover, MALAT1 inhibition enhanced the antitumor efficacy of sorafenib in vivo Clinically, we found that MALAT1 expression was negatively correlated with miR +genetics_overexpression_promote 32220639 hsa-mir-377 Colorectal Neoplasms Functional studies showed that overexpression of miR +genetics_overexpression_promote 32220622 hsa-mir-200c Fibrosis, Renal Overexpression of fascin-1 could reverse the effects of miR-200b/c family on renal fibrosis, and fascin-1 regulated renal fibrosis by activating CD44. +genetics_overexpression_promote 32220622 hsa-mir-200b Fibrosis, Renal Overexpression of fascin-1 could reverse the effects of miR-200b/c family on renal fibrosis, and fascin-1 regulated renal fibrosis by activating CD44. +circRNA target 32220601 hsa-mir-136 Granulomatosis with Polyangiitis For another, the functions of hsa_circ_0118530 on KGN cell progression, oxidative stress and inflammation releases were obviously reversed by miR-136 suppression. +genetics_knock down_suppress 32220601 hsa-mir-136 Polycystic Ovary Syndrome In conclusion, knockdown of hsa_circ_0118530 repressed PCOS progression via sponging miR-136. +other 32220540 hsa-mir-34a Multiple Myeloma Over-expression of miR-34a reduces MARCKS expression and sensitizes resistant cells to anti-myeloma drugs. This study uncovers a mechanism of drug resistance involving miR-34a-MARCKS autoregulatory loop and provides a framework for a potentially new therapeutic strategy to overcome drug resistance in multiple myeloma. +circulation_biomarker_diagnosis_up 32220185 hsa-mir-503 Uterine Cervical Neoplasms The plasmids were separately or jointly transinfected into cervical cancer Hela cells of each group by Lipofectamine 2000, After transinfection, the target gene was predicted by gene prediction software, the targeting relationship was verified by fluorescein experiment, the expression of miR +genetics_overexpression_promote 32220063 hsa-mir-15b Adenocarcinoma of Lung RESULTS: We determined that miR-15b was overexpressed in LUAD and miR-15b overexpression predicted a significantly worse outcome in patients with LUAD. +other 32219698 hsa-mir-181c Ciliary Motility Disorders 3p, and SIRT1 protein was upregulated in DG of ICSS rats (P < 0.05). +other 32219698 hsa-mir-132 Ciliary Motility Disorders 3p, and SIRT1 protein was upregulated in DG of ICSS rats (P < 0.05). +genetics_knock down_promote 32218861 hsa-mir-31 Thyroid Cancer, Papillary 3p significantly abrogated the effects of lncBRM knockout on PTC cell proliferation, migration and invasion. +lncRNA target 32218853 hsa-mir-145 Urinary Bladder Neoplasms 5p, which is a tumor suppressor in bladder carcinoma. +lncRNA target 32218846 hsa-mir-298 Thyroid Neoplasms miR-298 can inhibit the proliferation of thyroid cells and promote apoptosis of thyroid cancer cells by regulating the expression of CDK6, which is expected to be a potential target for clinical application. +lncRNA target 32218845 hsa-mir-212 Nasopharyngeal Carcinoma This suggested that the miR-212/ELF3 axis may serve as a novel target for the diagnosis and treatment of NPC. +circulation_biomarker_diagnosis_up 32218841 hsa-mir-125a Leukemia, Acute The level of miR-125a-3p in peripheral blood of children with AL is obviously decreased. +lncRNA target 32218824 hsa-mir-939 Carcinoma, Hepatocellular 3p/ESR1 axis may be a potential novel target for the treatment of HCC. +genetics_GWAS 32218819 hsa-mir-1 Colorectal Neoplasms Thus, performing a functional analysis of miR-31 expression may lead to the development of new targeted therapies for the various genetic subtypes of CRC. +circulation_biomarker_diagnosis_ns 32218818 hsa-mir-940 Carcinoma, Pancreatic Ductal 5p/miR-8069 ratio in exosomes tended to be higher in the urine than in the serum of patients with PDAC. +circulation_biomarker_diagnosis_ns 32218818 hsa-mir-8069 Carcinoma, Pancreatic Ductal 5p/miR-8069 ratio in exosomes tended to be higher in the urine than in the serum of patients with PDAC. +other 32218741 hsa-mir-17 Depression 92 levels in CHD patients after PCI. +other 32218741 hsa-mir-17 Anxiety Disorders 92 levels in CHD patients after PCI. +other 32218690 hsa-mir-27b gastric adenocarcinoma In our previous study, we identified three miRNAs (hsa-miR-421, hsa-miR-29b5p, and hsa-miR-27b-5p) with two mRNAs (FBXO11 and CREBZF) that might play an important role in the development of gastric adenocarcinoma (GAC) from premalignant adenomas. +lncRNA target 32218690 hsa-mir-29b-1 gastric adenocarcinoma 5p inhibition may be important to prevent the progression of gastric cancer in its early stage. +lncRNA target 32218690 hsa-mir-421 gastric adenocarcinoma 5p inhibition may be important to prevent the progression of gastric cancer in its early stage. +other 32218383 hsa-mir-133a Non-ST Elevated Myocardial Infarction Lastly, we hypothesized that Mir-133a may find a new use as a risk stratification biomarker in patients with specific subsets of non-ST elevation myocardial infarction (NSTEMI). +lncRNA target 32217689 hsa-mir-574 Thyroid Neoplasms Therefore, targeting NF-kappaB/miR-574 signaling may reduce the aggressiveness of thyroid cancer. +circulation_biomarker_diagnosis_up 32217110 hsa-mir-205 Crisponi syndrome MALAT1 and miR5p were both significantly upregulated in the serum of CIS patients and HBMECs under OGD/R, and the tube formation of HBMECs was damaged after OGD/R treatment. +lncRNA target 32216830 hsa-mir-146a Arthritis, Rheumatoid CONCLUSION: RvD1 is prone to alleviate RA progression through the upregulation of miRNA-146a-5p to suppress the expression of CTGF and inflammatory mediators, thereby decreasing pannus formation and cartilage damage. +circulation_biomarker_diagnosis_up 32216635 hsa-mir-521 cervical squamous cell carcinoma Results: Serum miR-638, miR-203a-3p, miR +circulation_biomarker_diagnosis_up 32216635 hsa-mir-638 cervical squamous cell carcinoma Results: Serum miR-638, miR-203a-3p, miR +lncRNA target 32216582 hsa-mir-338 Stomach Neoplasms 3p acts as a tumor suppressor in gastric cancer, possibly by directly targeting SOX5 and blocking Wnt/beta-catenin signaling. +transcription factor target 32216509 hsa-mir-195 Carcinoma, Hepatocellular Additionally, ultra-structural criteria of HCC were depicted, in the 12(th) week, in DEN-injected group, versus the 8(th) week, in the miRNAtreated group.Conclusions: Intra-hepatic injection of miRNA-195 vector induced apoptotic gene expression and suppressed anti-apoptotic gene but these favorable anti-cancer effects could not counteract the inflammatory, and subsequently, the oncogenic effect probably caused by vector administration. +other 32216502 hsa-mir-146a Arthritis, Rheumatoid The RNA level of miR-146a was decreased in RA tissues and was negatively related to the expression of GATA transcription factor 6 (GATA6). +lncRNA target 32216491 hsa-mir-21 Keloid We investigated whether Galla chinensis ointment inhibits keloid fibroblast proliferation through expression of microRNA-21, phosphorylated (p)-phosphatidylinositol 3-kinase (p-PI3K), chromosome 10 neutropenic protein phosphatase (PTEN), protein kinase B (p-Akt), and mammalian target of rapamycin (p-mTOR). +other 32215990 hsa-mir-23a Breast Neoplasms Expression of 3 small RNAs, namely isomiR of miR5p (3' addition C), miR-23a-3p and tRF-Lys (TTT), was significantly higher in BC samples and was validated by small RNA sequencing in an independent cohort. +other 32215990 hsa-mir-21 Breast Neoplasms Expression of 3 small RNAs, namely isomiR of miR5p (3' addition C), miR-23a-3p and tRF-Lys (TTT), was significantly higher in BC samples and was validated by small RNA sequencing in an independent cohort. +circulation_biomarker_diagnosis_ns 32215864 hsa-mir-3692 Carcinoma, Non-Small-Cell Lung Differential expression of circulating serum miR +circulation_biomarker_prognosis_up 32215864 hsa-mir-195 Carcinoma, Non-Small-Cell Lung 3p was significantly downregulated (p<0.0001) in the serum of NSCLC patients as compared to controls. +other 32215864 hsa-mir-1249 Carcinoma, Non-Small-Cell Lung The expression of miR3p was significantly upregulated in lung adenocarcinoma versus lung squamous cell carcinoma (p=0.0178). +lncRNA target 32215815 hsa-mir-375 Carcinoma, Hepatocellular CONCLUSIONS: MiR-375 impairs the invasive capabilities of HCC cells by targeting HIF1alpha under hypoxia. +circulation_biomarker_diagnosis_ns 32215780 hsa-mir-655 Multiple Sclerosis 3p in peripheral blood of patients with RRMS undergoing treatment with fingolimod compared with healthy controls. +circulation_biomarker_diagnosis_ns 32215780 hsa-mir-381 Multiple Sclerosis 3p in peripheral blood of patients with RRMS undergoing treatment with fingolimod compared with healthy controls. +circulation_biomarker_diagnosis_ns 32215780 hsa-mir-217 Multiple Sclerosis 3p in peripheral blood of patients with RRMS undergoing treatment with fingolimod compared with healthy controls. +circulation_biomarker_diagnosis_ns 32215780 hsa-mir-449a Multiple Sclerosis 3p in peripheral blood of patients with RRMS undergoing treatment with fingolimod compared with healthy controls. +circulation_biomarker_diagnosis_ns 32215780 hsa-mir-1827 Multiple Sclerosis 3p in peripheral blood of patients with RRMS undergoing treatment with fingolimod compared with healthy controls. +circulation_biomarker_diagnosis_ns 32215780 hsa-mir-506 Multiple Sclerosis 3p in peripheral blood of patients with RRMS undergoing treatment with fingolimod compared with healthy controls. +other 32215292 hsa-let-7 Myocardial Infarction We then analyzed the microRNAs in ADSCs and ADSC-derived MIVs and demonstrated that ADSC-derived MIVs selectively released a panel of microRNAs, several of which were related to angiogenesis, including two members of the let-7 family. +circulation_biomarker_diagnosis_up 32215263 hsa-mir-1 Lung Neoplasms We found that smoking had significant effects on the levels of circulating microRNAs in the smokers of the cancer-free group (a significant up-regulation of miR-10b and significant down-regulation of miR-1/miR-30a), and lung cancer patients (a significant elevation of miR-10b). +circulation_biomarker_diagnosis_up 32215263 hsa-mir-10b Lung Neoplasms We found that smoking had significant effects on the levels of circulating microRNAs in the smokers of the cancer-free group (a significant up-regulation of miR-10b and significant down-regulation of miR-1/miR-30a), and lung cancer patients (a significant elevation of miR-10b). +lncRNA target 32215262 hsa-mir-133b Prostatic Neoplasms The results of this study revealed significant changes in the expression of 14 microRNAs and 40 relevant target genes, which ultimately composed four combination panels (miR- 375+96+663/ miR- 133b+143- 3p 205/ C2ORF72 ENTPD5 GLYAT11/LAMB3 NTNG2+TSLP) as candidate biomarkers capable to distinguish between PCa tumor samples and normal prostate tissue samples. +lncRNA target 32215262 hsa-mir-143 Prostatic Neoplasms The results of this study revealed significant changes in the expression of 14 microRNAs and 40 relevant target genes, which ultimately composed four combination panels (miR- 375+96+663/ miR- 133b+143- 3p 205/ C2ORF72 ENTPD5 GLYAT11/LAMB3 NTNG2+TSLP) as candidate biomarkers capable to distinguish between PCa tumor samples and normal prostate tissue samples. +lncRNA target 32215262 hsa-mir-205 Prostatic Neoplasms The results of this study revealed significant changes in the expression of 14 microRNAs and 40 relevant target genes, which ultimately composed four combination panels (miR- 375+96+663/ miR- 133b+143- 3p 205/ C2ORF72 ENTPD5 GLYAT11/LAMB3 NTNG2+TSLP) as candidate biomarkers capable to distinguish between PCa tumor samples and normal prostate tissue samples. +lncRNA target 32215042 hsa-mir-92b Diabetic Nephropathies CONCLUSION: The results of the current study suggested that miR-92b-3p could mediate AGE-induced development of renal abnormalities through targeting Smad7 in rats with DN. +lncRNA target 32214905 hsa-mir-10a Sepsis Compared with infection patients and healthy controls, PBMC from sepsis patients also had higher levels of mitogen-activated kinase kinase kinase 7 (MAP3K7), a known target protein of miR-10a and an activator of the NF-kappaB pathway. +genetics_overexpression_promote 32214825 hsa-mir-138 low grade glioma MiR-138 overexpression in LGG cells was achieved by miR-138 mimics transfection. +genetics_knock down_promote 32214824 hsa-mir-154 Nasopharyngeal Carcinoma Rescue experiments showed that knockdown of KIF14 reversed the effect of inhibiting miR +lncRNA target 32214804 hsa-mir-34a Osteoarthritis To further validate the effect of miR-34a on the PI3K/Akt pathway, the cartilage cells were divided into blank control (BC), osteoarthritis model (OA), osteoarthritis model miR-34a inhibitor (OA 34aI), osteoarthritis model PI3K activator (OA IGF-1) and osteoarthritis model miR-34a inhibitor PI3K inhibitor (OA 34aI LY) groups, the experiments above were repeated. +genetics_overexpression_suppress 32214367 hsa-mir-520b Liver Neoplasms In addition, our results showed that overexpression of the MLK3 expression partially reversed the effect of miR-520b on liver cancer cell migration, indicating that MLK3 contributes to the migration in liver cancer. +genetics_knock down_promote 32214198 hsa-mir-200 Ovarian Neoplasms Herewith, we show that ovarian surface epithelial (OSE) cells with ectopic miR-200 expression formed stabilized cysts in three-dimensional (3D) organotypic culture with E-cadherin fragment expression and steroid hormone pathway activation, whereas ovarian cancer 3D cultures with miR-200 knockdown showed elevated TGF-beta expression, mitotic spindle disorientation, increased lumenization, disruption of ROCK-mediated myosin II phosphorylation, and SRC signaling, which led to histotype-dependent loss of collective movement in tumor spread. +genetics_knock down_promote 32214198 hsa-mir-200 Ovarian Cysts Herewith, we show that ovarian surface epithelial (OSE) cells with ectopic miR-200 expression formed stabilized cysts in three-dimensional (3D) organotypic culture with E-cadherin fragment expression and steroid hormone pathway activation, whereas ovarian cancer 3D cultures with miR-200 knockdown showed elevated TGF-beta expression, mitotic spindle disorientation, increased lumenization, disruption of ROCK-mediated myosin II phosphorylation, and SRC signaling, which led to histotype-dependent loss of collective movement in tumor spread. +circulation_biomarker_diagnosis_ns 32214121 hsa-mir-499a Myocardial Infarction, Acute For miR-133a and miR-26a, differences were only detected in serum (p = 0.0240), and conversely, miR-499a showed differences only in plasma of NSTEMI (p = 0.001). +circulation_biomarker_diagnosis_ns 32214121 hsa-mir-26a Myocardial Infarction, Acute For miR-133a and miR-26a, differences were only detected in serum (p = 0.0240), and conversely, miR-499a showed differences only in plasma of NSTEMI (p = 0.001). +circulation_biomarker_diagnosis_ns 32214121 hsa-mir-133a Myocardial Infarction, Acute For miR-133a and miR-26a, differences were only detected in serum (p = 0.0240), and conversely, miR-499a showed differences only in plasma of NSTEMI (p = 0.001). +other 32213710 hsa-mir-148a Autoimmune Diseases Therefore, these results identify a pivotal role for the PU.1-miR-148a-MAFB circuit in moDC differentiation and suggest a potential therapeutic avenue for autoimmunity. +lncRNA target 32213297 hsa-mir-545 Colonic Neoplasms CONCLUSION: LINC00342 affected cell biological activities of COAD in vivo and in vitro via regulating miR +transcription factor target 32213240 hsa-mir-181c Reperfusion Injury These observations determine that downregulated miR-181c ameliorates I/R via increasing the expression of c-Fos and its downstream genes, which will provide a new and promising therapeutic target for cerebral I/R. +other 32213205 hsa-mir-187 Prostatic Neoplasms CONCLUSION: The miRNA-182 and miRNA-187 appear to be promising biomarkers in prostate cancer and miRNA-187 can serve as an important diagnostic marker of metastatic prostate cancer. +circRNA target 32213200 hsa-mir-1275 Breast Neoplasms CONCLUSIONS: circCDYL promotes BC progression via the miRATG7/ULK1-autophagic axis and circCDYL could act as a potential prognostic and predictive molecule for breast cancer patients. +lncRNA target 32212891 hsa-mir-15a Status Epilepticus The interaction between miR-15a-5p and NR2B was assessed using a luciferase reporter assay.Propofol inhibited cell apoptosis and increased miR-15a-5p expression both in hippocampal tissues of SE rats and low Mg(2+)-induced hippocampal neurons. In vivo experiment suggested that propofol inhibited the apoptosis of hippocampal neurons in SE rats by upregulating miR-15a-5p.In terms of the molecular mechanism of propofol, it appears to inhibit apoptosis of hippocampal neurons in SE through the miR-15a-5p/NR2B/ERK1/2 pathway. +circulation_biomarker_diagnosis_down 32212883 hsa-mir-421 Atherosclerosis CONCLUSION: We demonstrated that elevated expression of CXCL2 in plaques, PBMCs, and serum of patients with coronary atherosclerosis was related to downregulation of miR-421 expression. +other 32212853 hsa-mir-126 Lung Injury The role of miR-126 in lung microvascular endothelial cells, which are essential for gas exchange and for lung injury repair and regeneration, remains poorly understood. +transcription factor target 32212793 hsa-mir-101 Carcinoma, Non-Small-Cell Lung The aim of this study was to investigate the effect of miRNA-101 on Mcl-1 expression and sensitivity of the A549 NSCLC cells to ABT-737. Therefore, miRNA-101 can be considered as a potential therapeutic target in patients with non-small cell lung cancer.
. +exosome 32212417 hsa-mir-27a Adenocarcinoma of Lung The upregulation of ICOS(+) T cell functions caused by the downregulation of miR-27a-3p in adipose tissue derived exosomes is one of the potential mechanisms for the improved efficacy of immunotherapy in obese LUAD patients. +genetics_GWAS 32212358 hsa-mir-182 Multiple Sclerosis CONCLUSION: Our findings illustrated that the pri-miR-182 rs4541843 G>A polymorphism is associated with the risk of MS in Isfahan population. +other 32212290 hsa-mir-20a Stomach Neoplasms CONCLUSION: Upregulation of hsa_circ_0001649 restrained GC cell growth and metastasis by downregulating miR-20a and thereby inactivated ERK and Wnt/beta-catenin pathways. +genetics_overexpression_suppress 32211853 hsa-mir-1323 Breast Neoplasms Low expression of miR-1323 contributed to the overexpression of TPD52 leading to enhanced BC progression. +genetics_knock down_promote 32211849 hsa-mir-4465 Ovarian Neoplasms In this study, we demonstrated that SDHAP1 was upregulated in PTX-resistant SKOV3 and Hey-8 ovarian cancer cell lines while the level of miR-4465 was downregulated. +lncRNA target 32211804 hsa-mir-802 Inflammatory Bowel Diseases Our study suggests that up-regulation of miR-802 plays an important role in inflammatory process of IBD via targeting SOCS5. +lncRNA target 32211330 hsa-mir-196a Glioblastoma CYBRD1 and TPTEP1-miR-196a-5p-RUFY2 regulation axes indicated that the two proteins may act as an oncogene and tumor suppressor, respectively, in the development of GBM. +lncRNA target 32211330 hsa-mir-637 Glioblastoma CYBRD1 and TPTEP1-miR-196a-5p-RUFY2 regulation axes indicated that the two proteins may act as an oncogene and tumor suppressor, respectively, in the development of GBM. +circulation_biomarker_diagnosis_down 32211116 hsa-mir-203 Lesch-Nyhan Syndrome Furthermore, circulating miR-203 expression was positively correlated with the serum concentrations of C3 and C4, and negatively correlated with the serum expression of IL-1beta, IL-6, and TNF-alpha in active LN patients. +other 32211116 hsa-mir-203 Lupus Erythematosus, Systemic A previous study showed that altered miR-203 expression may provide highly diagnostic for systemic lupus erythematosus. +transcription factor target 32211094 hsa-mir-144 Dmd-Associated Dilated Cardiomyopathy However, little is known about the biologic functions of miR-144 in DCM progression. CONCLUSION: MiR-144 regulates proliferation and apoptosis of HG-induced AC16 cardiomyocytes through targeting the CTRP3/JNK signaling pathway, providing a novel avenue for treatment of DCM. +genetics_overexpression_promote 32210951 hsa-mir-146a Myasthenia Gravis with Thymus Hyperplasia Microdissection experiments revealed that miR-146a deficiency in hyperplastic MG thymuses was not due to GCs, but restricted to the GC-surrounding medulla, characterized by IRAK1 overexpression. +transcription factor target 32210827 hsa-mir-18a osteogenesis imperfecta type 1 Moreover, intravitreal administration of miRNA mimic, agomiR-18a-5p, significantly suppressed retinal neovascularization in OIR models. +circulation_biomarker_diagnosis_up 32210807 hsa-mir-20a Osteoporosis Our results suggested that DIO could change the circulating miRNA profile of OVX rats and inhibited the downregulation of miR-20a-5p in serum and tibia. +genetics_overexpression_promote 32210729 hsa-mir-197 Prostatic Neoplasms Overexpression of miR +lncRNA target 32210677 hsa-mir-150 Squamous Cell Carcinoma of Head and Neck To explore the influence of mir-150 (M-150) ornithine decarboxylase (ODC) or inhibition in the development of oral squamous cell carcinoma (OSCC), the malignant tumor (MT) textures removed by surgical resection of maxillofacial tumors in patients with OSCC and the normal neighbor oral textures were collected. +circRNA target 32210655 hsa-mir-19a Leukemia, Lymphocytic, Chronic, B-Cell In this study, to specify the utility of circulatory miRNA expression as noninvasive and useful biomarkers for CLL, we analyzed the dysregulation of seven miRNAs: miR30d, miR25-3p, miR19a-3p, miR133b, miR451a, miR145, and miR144 in CLL-patient sera. Among these seven miRNAs, miR19a-3p and miR25-3p showed the most deregulation in CLL patients. +circRNA target 32210655 hsa-mir-25 Leukemia, Lymphocytic, Chronic, B-Cell In this study, to specify the utility of circulatory miRNA expression as noninvasive and useful biomarkers for CLL, we analyzed the dysregulation of seven miRNAs: miR30d, miR25-3p, miR19a-3p, miR133b, miR451a, miR145, and miR144 in CLL-patient sera. Among these seven miRNAs, miR19a-3p and miR25-3p showed the most deregulation in CLL patients. +other 32210627 hsa-mir-21 Choledocholithiasis CONCLUSION: Patients with HL-CCA show high incidence of hepatic abscess and elevated miRNA-21 and miRNA-221 expression level. +other 32210627 hsa-mir-221 Cholangiocarcinoma CONCLUSION: Patients with HL-CCA show high incidence of hepatic abscess and elevated miRNA-21 and miRNA-221 expression level. +other 32210627 hsa-mir-21 Cholangiocarcinoma CONCLUSION: Patients with HL-CCA show high incidence of hepatic abscess and elevated miRNA-21 and miRNA-221 expression level. +other 32210627 hsa-mir-221 Choledocholithiasis CONCLUSION: Patients with HL-CCA show high incidence of hepatic abscess and elevated miRNA-21 and miRNA-221 expression level. +lncRNA target 32210625 hsa-mir-34a Glioblastoma However, upregulation of Notch-1, a target of miR-34a, was observed after FEZF1-AS1 in GBM cells. +lncRNA target 32210583 hsa-mir-711 Osteosarcoma CONCLUSION: Osteosarcoma is suppressed by hsa_circ_0008792/hsa-miR-711/ZFP1 axis. +lncRNA target 32210581 hsa-mir-483 Glioma CONCLUSION: MiR-483 inhibited glioma cell migration, invasion, and promoted glioma cell apoptosis by targeting SOX3. +lncRNA target 32210579 hsa-mir-29b Carcinoma, Hepatocellular Hence, HANR increased autophagy-related sorafenib resistance via inhibiting the miR-29b/ATG9A axis in HepG2/sora and Huh7/sora cells, indicating that it may be a potential target to prevent chemoresistance of HCC. CONCLUSION: Our study revealed HANR enhanced sorafenib resistance by acting as an autophagy promoter by regulating miR-29b/ATG9A axis in sorafenibresistant HCC cells and might provide potential therapeutic strategies for HCC treatment. +circulation_biomarker_diagnosis_up 32210570 hsa-mir-96 Carcinoma, Hepatocellular CONCLUSION: This study showed that the expression levels of miRNA-122, miRNA-21 and miRNA-96 in exosomes were more significantly changed than those miRNAs in plasma in patients with HCC compared with cirrhotic patients, and the exosomal miRNA panel containing miRNA-122, miRNA-21 and miRNA-96 could be defined as a diagnostic biomarker for patients with HCC. +circulation_biomarker_diagnosis_up 32210570 hsa-mir-21 Carcinoma, Hepatocellular CONCLUSION: This study showed that the expression levels of miRNA-122, miRNA-21 and miRNA-96 in exosomes were more significantly changed than those miRNAs in plasma in patients with HCC compared with cirrhotic patients, and the exosomal miRNA panel containing miRNA-122, miRNA-21 and miRNA-96 could be defined as a diagnostic biomarker for patients with HCC. +circulation_biomarker_diagnosis_up 32210570 hsa-mir-122 Carcinoma, Hepatocellular CONCLUSION: This study showed that the expression levels of miRNA-122, miRNA-21 and miRNA-96 in exosomes were more significantly changed than those miRNAs in plasma in patients with HCC compared with cirrhotic patients, and the exosomal miRNA panel containing miRNA-122, miRNA-21 and miRNA-96 could be defined as a diagnostic biomarker for patients with HCC. +transcription factor target 32210552 hsa-mir-214 Squamous Cell Carcinoma of Head and Neck These results indicate that the GO-PEI-miR-214 inhibitor complex efficiently inhibited cellular miR-214, resulting in a decrease in OSCC cell invasion and migration and an increase in cell apoptosis by targeting PTEN and p53. +other 32210368 hsa-mir-802 Colorectal Neoplasms CONCLUSION: Our study demonstrates the oncogenic roles and underlying mechanisms of Ran in CRC and the novel miR-802/Ran/EGFR regulatory axis may provide potential biomarkers for the treatment of CRC. +other 32210284 hsa-mir-99a Hepatitis E We found that miR-125b-5p, miR5p, and miR-99a-5p may prove useful in the diagnosis of chronic hepatitis E. +other 32210284 hsa-mir-125b Hepatitis E We found that miR-125b-5p, miR5p, and miR-99a-5p may prove useful in the diagnosis of chronic hepatitis E. +exosome 32210284 hsa-mir-122 Hepatitis E miR-99a-5p, miR5p, and miR-125b-5p were upregulated in AHE (4.70-5.28 fold) and CHE patients (2.28-6.34 fold), compared to HEV-negative controls. +other 32210284 hsa-mir-192 Hepatitis E We found that miR-125b-5p, miR5p, and miR-99a-5p may prove useful in the diagnosis of chronic hepatitis E. +other 32210149 hsa-mir-34a Lung Injury Reprogramming fibrotic-lung myofibroblasts to regain susceptibility to cell-death by specifically increasing their miR34a and downregulating FLIP, may be a useful strategy, enabling tissue regeneration following lung injury. +other 32210149 hsa-mir-34a Pulmonary Fibrosis Reprogramming fibrotic-lung myofibroblasts to regain susceptibility to cell-death by specifically increasing their miR34a and downregulating FLIP, may be a useful strategy, enabling tissue regeneration following lung injury. +other 32210149 hsa-mir-34 Pulmonary Fibrosis Reprogramming fibrotic-lung myofibroblasts to regain susceptibility to cell-death by specifically increasing their miR34a and downregulating FLIP, may be a useful strategy, enabling tissue regeneration following lung injury. +other 32210149 hsa-mir-34 Lung Injury Reprogramming fibrotic-lung myofibroblasts to regain susceptibility to cell-death by specifically increasing their miR34a and downregulating FLIP, may be a useful strategy, enabling tissue regeneration following lung injury. +circulation_biomarker_prognosis_ns 32210110 hsa-mir-371a Testicular Germ Cell Tumor We aimed to assess the value of CRIPTO as a diagnostic and prognostic biomarker of testicular GCTs (TGCTs) and also to assess its presence in seminal plasma samples, compared with miR-371a-3p. CRIPTO/miR-371a-3p were detected both in normospermic and azoospermic males, and levels were higher in TGCTs compared to GCNIS-only. +circulation_biomarker_prognosis_ns 32210110 hsa-mir-371a Azoospermia We aimed to assess the value of CRIPTO as a diagnostic and prognostic biomarker of testicular GCTs (TGCTs) and also to assess its presence in seminal plasma samples, compared with miR-371a-3p. CRIPTO/miR-371a-3p were detected both in normospermic and azoospermic males, and levels were higher in TGCTs compared to GCNIS-only. +circulation_biomarker_diagnosis_ns 32210101 hsa-mir-367 Testicular Germ Cell Tumor New microRNA-based serum biomarkers (miRNA +transcription factor target 32209726 hsa-mir-19a Colorectal Neoplasms We demonstrated that PTEN was the target of miR-19a and inhibition of miR-19a partially reversed the resistance of colorectal cancer to oxaliplatin via PTEN/PI3K/AKT pathway. +circRNA target 32209259 hsa-mir-1233 Breast Neoplasms In summary, we showed that circEHMT1 has potential as a prognostic factor in breast cancer and played a tumor suppressor role via the circEHMT1/miR3p/KLF4/MMP2 axis. +exosome 32209115 hsa-mir-26a Colorectal Neoplasms Furthermore, MALAT1/miR-26a/26b/FUT4 axis played an important role in exosome-mediated CRC progression. CONCLUSIONS: These data indicated that exosomal MALAT1 promoted the malignant behavior of CRC cells by sponging miR-26a/26b via regulating FUT4 and activating PI3K/Akt/mTOR pathway. +exosome 32209115 hsa-mir-26b Colorectal Neoplasms Furthermore, MALAT1/miR-26a/26b/FUT4 axis played an important role in exosome-mediated CRC progression. CONCLUSIONS: These data indicated that exosomal MALAT1 promoted the malignant behavior of CRC cells by sponging miR-26a/26b via regulating FUT4 and activating PI3K/Akt/mTOR pathway. +other 32208417 hsa-let-7a Squamous Cell Carcinoma of Head and Neck CONCLUSION: This study concluded that salivary miR-let-7a-5p and miR-3928 has the potential to be novel non-invasive biomarkers for early detection and prognosis of HNSCC. +other 32208417 hsa-mir-3928 Squamous Cell Carcinoma of Head and Neck CONCLUSION: This study concluded that salivary miR-let-7a-5p and miR-3928 has the potential to be novel non-invasive biomarkers for early detection and prognosis of HNSCC. +circRNA target 32208321 hsa-mir-515 Urinary Bladder Neoplasms 5p reversed the repressive effects of si-circ_102336 on BC cell proliferation viability. +other 32207842 hsa-mir-133a Cardiovascular Diseases MicroRNA-133a (miR-133a) has been reported as a novel biomarker in various cardiovascular diseases. +circulation_biomarker_diagnosis_ns 32207842 hsa-mir-133a Coronary Artery Disease CONCLUSIONS: This study demonstrates for the first time that serum miR-133a can be used as a novel biomarker for early identification of stable CAD patients at risk of PMI undergoing elective PCI. +circulation_biomarker_diagnosis_ns 32207842 hsa-mir-133a Pelizaeus-Merzbacher Disease The circulating level of miR-133a was significantly higher in patients with PMI before and after the procedure (both p < 0.001). +lncRNA target 32207618 hsa-let-7a Liver Neoplasms Depending on the nucleic acid's hybridization and configuration transform, the designed nanochannel sensing systems can realize the intelligent detection of multiple liver cancer-related miRNA (miR-122 and miR Let-7a) integrating with cascaded INHIBIT-OR logic gate to provide theoretical guidance and technical support for clinical diagnosis and therapeutic evaluation of liver cancer. +lncRNA target 32207618 hsa-mir-122 Liver Neoplasms Depending on the nucleic acid's hybridization and configuration transform, the designed nanochannel sensing systems can realize the intelligent detection of multiple liver cancer-related miRNA (miR-122 and miR Let-7a) integrating with cascaded INHIBIT-OR logic gate to provide theoretical guidance and technical support for clinical diagnosis and therapeutic evaluation of liver cancer. +circulation_biomarker_diagnosis_up 32207596 hsa-mir-146a Alzheimer Disease METHODS: Clinical case study: 20 AD patients and 20 age-gender matched non-inflammatory and non-dementia patients in the department of neurology of our hospital were included, peripheral venous blood and cerebrospinal fluid were collected, and mir-146a levels in peripheral blood and cerebrospinal fluid were detected by real-time fluorescence quantitative PCR. +other 32207584 hsa-mir-133 Dmd-Associated Dilated Cardiomyopathy This indicates a link between miR-133 and cardiac remodeling in DCM. +other 32207410 hsa-mir-340 Esophageal Squamous Cell Carcinoma 5p functioned as an oncogene of ESCC by directly binding and repressing the expression of PIK3C3. +lncRNA target 32207384 hsa-mir-9 Carcinoma, Renal Cell In addition, LMX1A expression suppression induced by transfection of miR9 mimics confirmed that miR9 exerted its function in renal cell carcinoma by regulating LMX1A expression. In conclusion, circMTO1 suppresses renal cell carcinoma progression by circMTO1/miR9/ LMX1A, indicating that circMTO1 may be a potential target in renal cell carcinoma therapy. +lncRNA target 32207096 hsa-mir-200a Urinary Bladder Neoplasms This study first demonstrated that SNHG16 was responsible for EMT of BCa cells via miR-200a-3p/ ZEB1/ZEB2 axis. +lncRNA target 32207045 hsa-mir-124 Lymphoma, Large B-Cell, Diffuse CONCLUSION: Taken together, our study uncovered a mechanism by which active NF-kappaB signaling disrupts the function of miR-124 as a tumor suppressor in DLBCL. +lncRNA target 32206944 hsa-mir-449b Inflammation These findings demonstrated that TUG1 silencing attenuates I/R-induced inflammation and apoptosis via targeting miR-449b-5p and regulating HMGB1 and MMP2 expression. +circulation_biomarker_diagnosis_up 32206491 hsa-mir-21 Carcinoma, Ovarian Epithelial Present study revealed up-regulated expression of miR-21 and down regulated expression of miR-22 in the serum of epithelial ovarian cancer patients. +circulation_biomarker_diagnosis_up 32206491 hsa-mir-22 Carcinoma, Ovarian Epithelial Present study revealed up-regulated expression of miR-21 and down regulated expression of miR-22 in the serum of epithelial ovarian cancer patients. +other 32206406 hsa-mir-211 Mouth Neoplasms oxide to produce oral carcinogenesis in different stages, including normal, premalignancy and cancer. +other 32206186 hsa-mir-155 Gastritis This suggests that it may be possible to therapeutically attenuate miR-155 levels for gastric cancer treatment and/or to prevent the progression of chronic gastric inflammation into cancer. +lncRNA target 32206115 hsa-mir-20a Carcinoma, Hepatocellular 5p and miR-20a-5p could suppress postoperative metastasis of hepatocellular carcinoma via blocking HGF/ERBB3-NF-kappaB positive feedback loop and offer a new probable strategy for metastasis prevention after HCC resection. +lncRNA target 32206115 hsa-mir-17 Carcinoma, Hepatocellular 5p and miR-20a-5p could suppress postoperative metastasis of hepatocellular carcinoma via blocking HGF/ERBB3-NF-kappaB positive feedback loop and offer a new probable strategy for metastasis prevention after HCC resection. +genetics_knock down_suppress 32206110 hsa-mir-1 Colorectal Neoplasms Method: We established a CRC targeted delivery system, in which alpha-lactalbumin peptosomes (PSs) co-loaded with a microRNA (miR)-31 inhibitor (miR-31i) and curcumin (Cur) were encapsuslated in thiolated TEMPO oxidized Konjac glucomannan (sOKGM) microspheres, referred as sOKGM-PS-miR-31i/Cur. +lncRNA target 32206066 hsa-mir-206 Carcinoma, Non-Small-Cell Lung CONCLUSION: Our study reveals that miR-206 functions as a tumor metastasis suppressor and sheds new light on the clinical significance of miR-206 in NSCLC therapy. +genetics_overexpression_suppress 32206065 hsa-mir-222 Hypoxia In addition, rescue assay suggested that the inhibition mediated by CASC2 of hypoxia-induced PASMC proliferation and migration could be attenuated by miR-222 inhibition or ING5 overexpression. CONCLUSION: CASC2 attenuated hypoxia-induced PASMC proliferation and migration by regulating the miR-222/ING5 axis to prevent vascular remodeling and the development of PAH, providing a novel insight and therapeutic strategy for hypoxia-induced PAH. +other 32206065 hsa-mir-222 Hypertension, Pulmonary CONCLUSION: CASC2 attenuated hypoxia-induced PASMC proliferation and migration by regulating the miR-222/ING5 axis to prevent vascular remodeling and the development of PAH, providing a novel insight and therapeutic strategy for hypoxia-induced PAH. +lncRNA target 32206063 hsa-mir-144 Colorectal Neoplasms 3p inhibits cell proliferation and delays G1/S phase transition of CRC cells. +lncRNA target 32206038 hsa-mir-34b Lymphoma, Large B-Cell, Diffuse CONCLUSION: We revealed that MYC-regulated NEAT1 promoted DLBCL proliferation via the miR-34b-5p-GLI1 pathway, which could provide a novel therapeutic target for DLBCL. +genetics_knock down_promote 32206036 hsa-mir-33a Triple Negative Breast Neoplasms EZH2 knockdown exerted similar inhibitory effects, while ectopic expression of EZH2 showed suppressive effects on malignant behaviors induced by miR-33a overexpression in TNBC cells. +exosome 32206004 hsa-mir-182 Gallbladder Neoplasms In addition, the effects of exosomal miR-182/RECK on the biological function of human GC cells were observed. +other 32205703 hsa-mir-29a Ossification, Heterotopic MiR-29a-5p was found to be downregulated in ligament cells from ossified ligament tissue in a previous study. +genetics_overexpression_promote 32205703 hsa-mir-29a Marfan Syndrome We additionally observed decreased miR-29a-5p expression during the process of TOLF osteogenic cell differentiation, and there was a marked reduction in the expression of key mediators of osteogenesis when miR-29a-5p was overexpressed. +genetics_GWAS 32205480 hsa-mir-371a Urogenital Neoplasms Other molecular methodologies currently available but not widely utilized for TGCTs include genome-wide and targeted approaches for specific genetic anomalies, P53 mutations, genomic MDM2 amplification, and detection of the p53 inactivating miR-371a-3p. +genetics_GWAS 32205480 hsa-mir-371a Testicular Germ Cell Tumor Other molecular methodologies currently available but not widely utilized for TGCTs include genome-wide and targeted approaches for specific genetic anomalies, P53 mutations, genomic MDM2 amplification, and detection of the p53 inactivating miR-371a-3p. +genetics_overexpression_suppress 32205184 hsa-mir-133a Diabetic Nephropathies The rescue experiments showed that IRF5 reversed the effect of miR-133a-3p mimic on inhibiting fibrosis, and reversed the effects on promoting apoptosis and reducing cell proliferation. CONCLUSION: Overexpressed miR-133a-3p inhibits fibrosis by down-regulating IRF5 and thus inhibiting the TGF-beta/Smad2 pathway. +genetics_overexpression_suppress 32205184 hsa-mir-133a Keloid The rescue experiments showed that IRF5 reversed the effect of miR-133a-3p mimic on inhibiting fibrosis, and reversed the effects on promoting apoptosis and reducing cell proliferation. CONCLUSION: Overexpressed miR-133a-3p inhibits fibrosis by down-regulating IRF5 and thus inhibiting the TGF-beta/Smad2 pathway. +transcription factor target 32205015 hsa-mir-145 Rift Valley Fever CONCLUSIONS: The study results suggests that miR-145 may target and down-regulate PAI-1 expression and influence embryo implantation in women with RIF who are undergoing IVF. +circulation_biomarker_diagnosis_up 32204765 hsa-mir-21 Acute Kidney Injury CONCLUSIONS: There is a significant increase in the serum level of miR +circulation_biomarker_diagnosis_up 32204765 hsa-mir-21 Sepsis CONCLUSIONS: There is a significant increase in the serum level of miR +circulation_biomarker_diagnosis_ns 32204685 hsa-mir-326 Thyroiditis, Autoimmune We examined whether Th17 cells and miR-326 were aberrantly altered in the peripheral blood mononuclear cells (PBMCs) of HT patients with flow cytometry and real-time polymerase chain reaction. +lncRNA target 32204466 hsa-mir-21 Osteoporosis Bioinformatic analyses identified HDCA2, PTX3, and FGF2 proteins as downstream targets of CTC-487M23.5, GAS5, and RP11-84C13.1 lncRNAs mediated by the interaction with miRNAs implicated in OP pathogenesis, including miR5p. +circulation_biomarker_prognosis_ns 32204444 hsa-mir-483 Adrenal Cortex Neoplasms Our study suggests that serum miR +other 32203705 hsa-mir-149 Ischemic Stroke CONCLUSION: Our meta-analysis results suggest that miR-149 rs2292832 might contribute to stroke susceptibility in the Asian populations. +other 32203705 hsa-mir-499 Ischemic Stroke RESULTS: In our case-control study, no association between miR-499 rs3746444, miR-149 rs2292832 and IS were found. +genetics_overexpression_suppress 32203665 hsa-mir-125a Lupus Erythematosus, Systemic Therefore, overexpression of miR-125a may have therapeutic potential to treat SLE. +transcription factor target 32203196 hsa-mir-140 Angelman Syndrome 5p can participate in inhibiting ox-LDL-induced oxidative stress and cell apoptosis via targeting TLR4 in macrophage-mediated ox-LDL induced AS. +genetics_knock down_promote 32203055 hsa-mir-3677 Osteosarcoma MiR-3677 overexpression-induced anti-OS cell activity was reversed with re-expression of the 3'-UTR-depleted SphK1. +other 32203053 hsa-mir-145 Fibrosis, Renal Next, MALAT1/miR-145/focal adhesion kinase (FAK) pathway was confirmed to play an importment role in TGF-beta1-induced renal fibrosis. In addition, the MALAT1/miR-145/FAK pathway was involved in the effect of dihydroartemisinin (DHA) on TGF-beta1-induced renal fibrosis in vitro and in vivo. +lncRNA target 32202941 hsa-mir-490 Carcinoma, Non-Small-Cell Lung 3p inhibitor could relieve SNHG6 silencing-mediated inhibition on proliferation and promotion on apoptosis in NSCLC. +genetics_knock down_suppress 32202906 hsa-mir-145 Lung Neoplasms In conclusion, the knockdown of PVT1 inhibited proliferation, migration, and invasion but induced apoptosis of NSCLC cells by regulating miR5p/ITGB8 axis and inhibiting MEK/ERK signaling pathway, providing a novel avenue for the treatment of NSCLC. +genetics_knock down_suppress 32202906 hsa-mir-145 Carcinoma, Non-Small-Cell Lung In conclusion, the knockdown of PVT1 inhibited proliferation, migration, and invasion but induced apoptosis of NSCLC cells by regulating miR5p/ITGB8 axis and inhibiting MEK/ERK signaling pathway, providing a novel avenue for the treatment of NSCLC. +other 32202735 hsa-mir-191 Acromegaly 5p 0.549 (p=0.039). +other 32202735 hsa-mir-342 Acromegaly 5p 0.549 (p=0.039). +other 32202735 hsa-mir-4446 Acromegaly 5p 0.549 (p=0.039). +other 32202349 hsa-mir-99b Esophageal Squamous Cell Carcinoma The results showed that the majority of miRNAs differentially expressed in the corpus luteum in early pregnancy vs regression belong to independent clusters (eg, miR-99b, miR-532), which are highly conserved among different animal species. The main conceptus signal in the pig (17beta-estradiol) elevated the luteal expression of the miR-99b cluster and lowered the expression of NR4A1 and AKR1C1, the genes involved in corpus luteum regression. +other 32202349 hsa-mir-532 Esophageal Squamous Cell Carcinoma The results showed that the majority of miRNAs differentially expressed in the corpus luteum in early pregnancy vs regression belong to independent clusters (eg, miR-99b, miR-532), which are highly conserved among different animal species. +genetics_overexpression_promote 32202300 hsa-mir-148a Squamous Cell Carcinoma of Head and Neck miR-148a overexpression could significantly impair OSCC cell proliferation, migration and invasion in vitro (P<0.05 for all). +lncRNA target 32202193 hsa-mir-21 Endometrial Hyperplasia Taken together, our findings indicated that UDCA inhibited intimal hyperplasia and VSMCs excessive migration and proliferation via blocking miR-21/PTEN/AKT/mTOR signaling pathway, which suggests that UDCA may be a promising candidate for the therapy of atherosclerosis. +circulation_biomarker_diagnosis_ns 32202040 hsa-mir-30 Diabetes, Gestational 3p was high-expressed in GDM patients' blood, while GCK was low-expressed. +lncRNA target 32201579 hsa-mir-93 Osteosarcoma 5p inhibition both at mRNA and protein level, a more significant cell response in terms of proliferation and apoptosis was seen in canine OS cells. +lncRNA target 32201542 hsa-mir-145 Pancreatic Carcinoma Scratch assay and transwell assay showed that miRNA-145 inhibited the migration and invasion in PC cells. +lncRNA target 32201538 hsa-mir-181 Melanoma Finally, in CM cells deriving from different culture history, we identified STAT3 to be a target gene of miR-181. +genetics_overexpression_suppress 32201531 hsa-mir-195 Carcinoma, Non-Small-Cell Lung 5p overexpression inhibited the proliferation, migration, and invasion of NSCLC-derived cells by directly targeting CPNE1. +transcription factor target 32201523 hsa-mir-23a Squamous Cell Carcinoma of Head and Neck Next, we focused on miR-23a-3p, which could target SIX1 in HNSCC cells. miR-23a-3p targeted the SIX1/GLUT3 axis and suppressed glucose uptake and proliferation in HNSCC. +transcription factor target 32201519 hsa-mir-100 Nasopharyngeal Carcinoma 5p or miR-125b-5p inhibited the malignant behaviors of NPC cells, whereas re-expression of miR +transcription factor target 32201519 hsa-mir-125b Nasopharyngeal Carcinoma 5p or miR-125b-5p inhibited the malignant behaviors of NPC cells, whereas re-expression of miR +genetics_overexpression_promote 32201518 hsa-mir-19a Carcinoma, Hepatocellular In this study, we found that miR-19a-3p is usually overexpressed in HCC tissues compared with corresponding peritumorous tissues, and its expression was associated with tumor size and poor overall survival. +lncRNA target 32201276 hsa-mir-942 Hepatitis B, Chronic SIGNIFICANCE: PPARgamma targeting by miR-942 and decreasing HSC activation in human hepatic fibrosis. +genetics_knock down_suppress 32200130 hsa-mir-462 Pancreatic Diseases In particular, knockdown of miR-462 caused pancreas morphogenesis abnormity with specific bilateral exocrine pancreas. +other 32199621 hsa-mir-200c Leiomyoma OBJECTIVE: To determine the mechanism by which tranilast induces miR-200c expression in leiomyoma smooth muscle cells (LSMCs). +lncRNA target 32199253 hsa-mir-1323 Stomach Neoplasms CONCLUSION: Our results suggested that beta-Elemene inhibits the metastasis of MDR gastric cancer cells by modulating the miR-1323/Cbl-b/EGFR signaling axis. +genetics_knock down_promote 32199224 hsa-mir-99a Ovarian Neoplasms Additionally, overexpression of miR-99a or knockdown of HDAC5 attenuated the promoting effects of YY1 on the stemness of OC cells. +genetics_overexpression_promote 32199130 hsa-mir-122 Osteoporosis We transfected isolated osteoblasts from ovariectomized rats with miR-122 mimic or inhibitor or PCP4 overexpression vectors. +genetics_knock down_promote 32199129 hsa-mir-195 Sarcoma, Ewing Taken together, AGAP2-AS1 knockdown exercises suppressive effects on the development of EC through miR +lncRNA target 32198978 hsa-mir-144 Multiple Myeloma 3p/c-MET axis, suggesting that SOX2OT might be as a potential therapeutic target for MM. +genetics_overexpression_suppress 32198911 hsa-mir-20a Arthritis It was found that MiR-20a was downregulated in RA tissues, and overexpressed miR-20a inhibited cell viability, migration and invasion, and the expression of inflammatory factors in RA-FLS MH7A cells. +other 32198822 hsa-mir-16-2 Pre-Eclampsia In summary, our study uncovered a novel DICER-miR2-COL1A2 mediated pathway involved in the invasion ability of EVT, and DICER-containing MVs mediate the pro-angiogenic effect of trophoblast-derived conditioned medium on angiogenesis, implying the involvement of DICER in the pathogenesis of PE. +other 32198770 hsa-mir-200c Breast Neoplasms In conclusion, these data reveal that XIST promotes chemoresistance of breast cancer cells to doxorubicin by sponging miR-200c-3p to upregulate ANLN. +other 32198621 hsa-mir-29b Diabetes Mellitus, Type 2 The present findings revealed that the downregulation of microRNA-29b in diabetes could be associated with memory impairment and increased BACE-1 activity. +lncRNA target 32198489 hsa-mir-299 Prostatic Neoplasms 3p through modulation of AR and VEGFA signaling pathways which lead to improved drug sensitivity of PCa. +circulation_biomarker_diagnosis_down 32198434 hsa-mir-6732 Nasopharyngeal Carcinoma 3p in serum might serve as potential biomarkers for predicting the radiosensitivity of NPC. +circulation_biomarker_diagnosis_down 32198434 hsa-mir-1281 Nasopharyngeal Carcinoma 3p in serum might serve as potential biomarkers for predicting the radiosensitivity of NPC. +genetics_GWAS 32198354 hsa-mir-1-2 Ileal Neoplasms Genetic events that attenuated RB activity, including loss of copy of MIR1-2 as well as loss of copy of CDKN1B and CDKN2A, were more frequent in tumors from patients with metastatic I-NETs. These data suggest that inhibitors of CDK4/CDK6 may benefit patients whose I-NETs show loss of copy of MIR1-2, particularly patients with metastatic disease. +genetics_overexpression_promote 32198053 hsa-mir-520d Uterine Cervical Neoplasms In addition, overexpression of miR-520d-5p resulted in apoptosis of CC cells. +transcription factor target 32197230 hsa-mir-125a Arthritis, Rheumatoid METHODS The peripheral expression of miRNAs, including miR-146a, miR-146b, miR-150, miR-155, miR-125a-5p, miR-223, miR-26a, and miR-21, as well as their target mRNAs, was analyzed in 90 RA patients and 30 HCs via quantitative real-time polymerase chain reaction (RT-PCR) assay. +lncRNA target 32197208 hsa-mir-361 Carcinoma, Non-Small-Cell Lung 3p was a target of PVT1 in NSCLC cells. +transcription factor target 32196963 hsa-mir-143 Carcinoma, Renal Cell We suggest that hsa-miR-143 is a potential tumor suppressor in RCC as its down regulation positively correlated with adverse prognosis. +genetics_overexpression_suppress 32196955 hsa-mir-590 Uterine Cervical Neoplasms Overexpression of miR +circulation_biomarker_diagnosis_ns 32196930 hsa-mir-1246 Laryngeal Neoplasms We found that miR-1246 was higher in LSCC tissues and plasma sEV. +circulation_biomarker_prognosis_ns 32196922 hsa-mir-210 Kidney Failure, Chronic Our data highlighted that chronic HD significantly reduces the circulating level of the miRNAs evaluated; within the targets analyzed, the miRNA-210 could be considered as a prognostic indicator of ESA responsiveness and index for anemia management. +lncRNA target 32196916 hsa-mir-155 Myocardial Infarction 5p in regulating MSC senescence and whether inhibition of miR +transcription factor target 32196852 hsa-mir-27 Cartilage Diseases 3p/MMP13 signaling axis might be a potential therapeutic target of And for preventing the progression of OA. +genetics_GWAS 32196811 hsa-mir-576 Pulmonary Disease, Chronic Obstructive Taken together, these results demonstrate that the rs2664370T>C polymorphism in MMP16 protects against the risk of COPD, likely by favoring interaction with hsa-miR5p, leading to reduced MMP16 expression and improved blood gas levels. +genetics_knock down_promote 32196731 hsa-mir-8 Addison Disease Notably, overexpression of miR3p or knockdown of its Vha targets in the PG resulted in larger than normal, ecdysone-deficient larvae that failed to develop into the pupal stage but could be rescued by ecdysone feeding. +lncRNA target 32196715 hsa-mir-337 Osteosarcoma 3p and then promote the progression of osteosarcoma, providing a potential therapeutic target for osteosarcoma. +genetics_knock down_promote 32196629 hsa-mir-761 Glioma Additionally, circ-TTBK2 knockdown or miR-761 increase could retard cell proliferation, invasion, and promote ferroptosis in glioma cells. +lncRNA target 32196624 hsa-mir-128-1 Atherosclerosis 1-5P inhibitor after treatment of human vascular smooth muscle cells with ox-LDL and Luciferase report experiments showed that Gadd45g was a direct target of miR +lncRNA target 32196624 hsa-mir-128 Atherosclerosis 1-5P inhibitor after treatment of human vascular smooth muscle cells with ox-LDL and Luciferase report experiments showed that Gadd45g was a direct target of miR +lncRNA target 32196616 hsa-mir-26a Myocardial Infarction, Acute OBJECTIVE: To study the influence of micro ribonucleic acid (miR)-26a on myocardial cell apoptosis in rats with acute myocardial infarction (AMI) through the glycogen synthase kinase 3 beta (GSK-3beta) pathway. CONCLUSIONS: MiR-26a activates the GSK-3beta signaling pathway to inhibit myocardial cell apoptosis after AMI. +transcription factor target 32196614 hsa-mir-195 Inflammatory Bowel Diseases MATERIALS AND METHODS: A rat model of UC was prepared by 2, 4, 6-trinitrobenzenesulfonic acid (TNBS)/ethanol assay, and the rats were randomly divided into Control group, Model group, and miR-195 mimic (miR-195 agomir) group. CONCLUSIONS: MiR-195 mimics can alleviate the pathological damage to the colon and inflammatory responses in UC model rats, and its mechanism may be related to the inhibition on the p38 MAPK signaling pathway. +other 32196613 hsa-mir-133a Sepsis This paper's aim was to investigate whether microRNA-133a had a protective effect on sepsis-induced kidney injury. MATERIALS AND METHODS: We established a kidney injury model with lipopolysaccharide (LPS) and divided TCMK-1 cells into 4 groups: control group (con); LPS treatment group; LPS negative control (NC) treatment group; LPS miR-133a mimic (mim) group. +other 32196613 hsa-mir-133a Kidney Diseases This paper's aim was to investigate whether microRNA-133a had a protective effect on sepsis-induced kidney injury. MATERIALS AND METHODS: We established a kidney injury model with lipopolysaccharide (LPS) and divided TCMK-1 cells into 4 groups: control group (con); LPS treatment group; LPS negative control (NC) treatment group; LPS miR-133a mimic (mim) group. +lncRNA target 32196612 hsa-mir-429 Melanoma 5p attenuates migration and invasion in MM by targeting LIMK1. +genetics_knock down_promote 32196611 hsa-mir-4435-2 Melanoma And knockdown of FLOT2 restrained the progression of melanoma by downregulating lncRNA MIR4435-2HG and upregulating miR-802. +genetics_knock down_suppress 32196610 hsa-mir-384 Glioma CONCLUSIONS: MALAT1 knockdown depleted migration and invasion by inhibiting autophagy through MALAT1/miR-384/GOLM1 axis in glioma in vitro and in vivo. +other 32196608 hsa-mir-127 Thyroid Neoplasms Further studies revealed that circ-0103552 was involved in the invasion and migration of TC by sponging miR-127. CONCLUSIONS: The present study demonstrated that circ-0103552 acts as a regulator in the invasion and migration of TC by sponging miR-127. +lncRNA target 32196605 hsa-mir-20a Carcinoma, Non-Small-Cell Lung CONCLUSIONS: MiRNA-20a-5p stimulates NSCLC to proliferate and invade by targeting KLF9. +lncRNA target 32196604 hsa-mir-214 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: Downregulation of lncRNA DANCR inhibited cell proliferation and induced cell apoptosis in NSCLC by regulating the miR +genetics_knock down_promote 32196603 hsa-mir-127 Carcinoma, Non-Small-Cell Lung 3p overexpression and MED28 knockdown in NSCLC cells. +genetics_knock down_suppress 32196601 hsa-mir-381 Nasopharyngeal Carcinoma CONCLUSIONS: XIST knockdown inhibited glycolysis and metastasis in hypoxia-induced NPC cells through regulating miR +lncRNA target 32196600 hsa-mir-203 Nasopharyngeal Carcinoma CONCLUSIONS: LINC00114 contributed to NPC development and radioresistance through the regulation of ERK/JNK signaling pathway and the mediation of miR-203, suggesting that LINC00114 was a promising biomarker to defense NPC progression and radioresistance. +lncRNA target 32196599 hsa-mir-150 Squamous Cell Carcinoma of Head and Neck Additionally, it may accelerate the malignant progression of OSCC via regulating microRNA-150. +genetics_knock down_suppress 32196598 hsa-mir-194 Squamous Cell Carcinoma of Head and Neck It was confirmed that miR-194 and miR-204 were targets of circ_0001971, and miR-194 inhibition or miR-204 inhibition reversed the effects of circ_0001971 knockdown in OSCC cells. CONCLUSIONS: Circ_0001971 regulates cell proliferation, migration, invasion, apoptosis, and chemosensitivity of OSCC by interacting with miR-194 and miR-204 in vitro and in vivo. +genetics_knock down_suppress 32196598 hsa-mir-204 Squamous Cell Carcinoma of Head and Neck It was confirmed that miR-194 and miR-204 were targets of circ_0001971, and miR-194 inhibition or miR-204 inhibition reversed the effects of circ_0001971 knockdown in OSCC cells. CONCLUSIONS: Circ_0001971 regulates cell proliferation, migration, invasion, apoptosis, and chemosensitivity of OSCC by interacting with miR-194 and miR-204 in vitro and in vivo. +genetics_overexpression_promote 32196597 hsa-mir-150 Esophageal Neoplasms Besides, overexpression of LINC00511 enhanced ECa cell proliferation and migration, accelerated cell cycle, and suppressed cell apoptosis, while transfection with microRNA +lncRNA target 32196594 hsa-mir-153 Stomach Neoplasms CONCLUSIONS: OIP5-AS1 exerted its role via miR3p/ZBTB2 axis in the progression of GC cells. +lncRNA target 32196591 hsa-mir-223 Colorectal Neoplasms CONCLUSIONS: The findings of this study first revealed that ROR was upregulated in colorectal cancer cells and can promote cell proliferation and invasion by inhibiting tumor suppressor gene NF2 through interacting with miR3p. +circRNA target 32196590 hsa-mir-760 Colorectal Neoplasms CONCLUSIONS: CircRNA circDENND4C accelerated proliferation, migration, and glycolysis of colorectal cancer cells through regulating GLUT1 by sponging miR-760. +other 32196589 hsa-mir-525 Colorectal Neoplasms The regulatory loop ADPGK-AS1/miR-525/FUT1 exacerbates the progression of CRC by promoting the proliferation, migration, and invasion of tumor cells. +lncRNA target 32196584 hsa-mir-345 Cholangiocarcinoma Moreover, the suppressive effects of high miR +lncRNA target 32196583 hsa-mir-486 Osteosarcoma CONCLUSIONS: We demonstrated that PVT1, functioning as an oncogene, promotes osteosarcoma cells metastasis via miR-486 sponging. +genetics_overexpression_promote 32196581 hsa-mir-370 Urinary Bladder Neoplasms The overexpression of miR-370 led to enhanced apoptosis in BC cells, while inhibiting cell proliferation, migration, and invasion, effectively blocking cancer metastasis. +circulation_biomarker_diagnosis_ns 32196580 hsa-mir-1252 Carcinoma, Endometrioid Based on the determined cytoplasmic location of AL161431.1, we investigated the ceRNA network and its relation to AL161431.1, miR +lncRNA target 32196576 hsa-mir-202 Ovarian Neoplasms 5p suppressed cell proliferation, migration, and invasion in OC via regulating HOXB2. +lncRNA target 32196575 hsa-mir-1 Ovarian Neoplasms 5p/PLCB1 could be utilized as a therapeutic target for OC. +genetics_knock down_suppress 32196574 hsa-mir-29c Osteosarcoma Cell proliferative capacity and invasiveness in OS were enhanced after knockdown of microRNA-29c-3p; while the opposite results were observed after the overexpression of microRNA-29c-3p. +lncRNA target 32196573 hsa-mir-141 Osteosarcoma CONCLUSIONS: MIAT silence suppresses OS progression through inactivating PI3K/AKT signaling by sponging miR3p to regulate SIX1, indicating a novel target for the treatment of OS. +other 32196572 hsa-mir-655 Osteosarcoma CONCLUSIONS: All our findings suggested that SP1-induced upregulation of LINC00689 promoted osteosarcoma progression by regulating miR-655/ SOX18 axis, which provided a novel insight for osteosarcoma tumorigenesis. +circulation_biomarker_diagnosis_ns 32196570 hsa-mir-375 Diabetic Retinopathy CONCLUSIONS: MiR-375 inhibitors are able to reduce blood glucose, retinal permeability, and optic ganglion apoptosis in rats with DR, and the mechanism of action may be related to the regulation on the Ndrg2/IL-6/STAT3 signaling pathway. +genetics_overexpression_suppress 32196384 hsa-mir-646 Osteosarcoma MT1JP and miR-646 overexpression inhibited the migration and invasion of OS cells. +circulation_biomarker_diagnosis_ns 32196088 hsa-mir-548x Osteoporosis We found high expression levels of miR-548x-3p in circulating monocytes derived from postmenopausal osteoporotic women. We validated by RT-qPCR, the elevated levels of miR-548x-3p in circulating monocytes derived from osteoporosis women. +circulation_biomarker_diagnosis_ns 32196088 hsa-mir-548x Osteoporosis, Postmenopausal We found high expression levels of miR-548x-3p in circulating monocytes derived from postmenopausal osteoporotic women. +lncRNA target 32195457 hsa-mir-22 Fatty Liver Consistent with this finding, an miR-22 inhibitor effectively reversed both alcohol- and diet-induced fatty liver; miR-22 inhibition is a promising therapeutic option which could be used in combination with obeticholic acid. +other 32195032 hsa-mir-181b Prostatic Neoplasms adjacent normal tissues from a cohort of human prostate cancer patients, we demonstrated that downregulation of MIIP was well associated with downregulation of KLF17 and E-cadherin, but upregulation of miR-181a/b-5p. +other 32195032 hsa-mir-181a Prostatic Neoplasms adjacent normal tissues from a cohort of human prostate cancer patients, we demonstrated that downregulation of MIIP was well associated with downregulation of KLF17 and E-cadherin, but upregulation of miR-181a/b-5p. +other 32194916 hsa-mir-363 Carcinoma, Renal Cell We further verified a ccRCC biomarker panel, which consists of lncRNA SNHG5, miR3p, and Twist1 in ccRCC tissue samples. +transcription factor target 32194911 hsa-mir-376a Coronary Artery Disease CONCLUSION: In this study, miR-376a-3p-NRIP1 pair might involve in the progression of CAD, implying that miR-376a-3p may be a therapeutic target for the treatment of CAD. +genetics_knock down_suppress 32194906 hsa-mir-140 Carcinoma, Hepatocellular Moreover, knockdown of miRNA-140 could stimulate metastatic ability in HCC. +other 32194901 hsa-mir-758 Thyroid Cancer, Papillary We also found that lincRNA02471 negatively regulate miR-758 in papillary thyroid cancer. lincRNA02471 can sponge miR-758 and positively regulate HIPK3 to promote papillary thyroid cancer development. +transcription factor target 32194869 hsa-mir-578 Choroidal Neovascularization The cZBTB44-miRVEGFA/VCAM1 axis might be a potential source of novel therapeutic targets for neovascularization-related diseases. +other 32194865 hsa-mir-21 Wounds and Injuries Thus, miR21 mimic nanocarriers improved both the rate and quality of wound healing, as evident from enhanced collagen synthesis and accelerated wound re-epithelialization. +lncRNA target 32194819 hsa-mir-1275 Adenocarcinoma of Lung Conclusions: Our findings identified miR-1275 as a potential oncogene in LUAD that exerts its tumorigenic effect through co-activating Wnt/beta-catenin and Notch signaling pathways. +lncRNA target 32194780 hsa-mir-152 Melanoma Taken together, our findings suggested that curcumol attenuated melanoma progression and concomitantly suppressed ERK/NF-kappaB signaling and promoted miR +lncRNA target 32194761 hsa-mir-205 Thyroid Neoplasms In conclusion, miR-205 inhibits the proliferation and migration of TC cells by targeting CCNB2, which may be a potential target of TC therapy. +lncRNA target 32194758 hsa-mir-875 Breast Neoplasms 3p could inhibit the proliferation ability of MCF-7 and BCap-37 cells, and partially reversed the promoting effect of GACAT1 on cell cycle. +circulation_biomarker_prognosis_ns 32194755 hsa-mir-223 Mouth Neoplasms Changes of serum miR +genetics_overexpression_promote 32194747 hsa-mir-205 Osteosarcoma ELF3-AS1 and KLF12 overexpression resulted in an increased proliferation rate in OS cells, while miR-205 played an opposite role and attenuated the effects of ELF3-AS1 overexpression. +genetics_overexpression_promote 32194733 hsa-mir-34a Uterine Cervical Neoplasms In CSCC cells, MACC1-AS1 overexpression led to upregulation of CDK6, while miR-34a overexpression had the opposite effect and reduced the effects of MACC1-AS1 overexpression in co-transfected cells. +other 32194732 hsa-mir-30 Uterine Cervical Neoplasms ADH7, VGLL3, CYP26B1, miR-3065, miR-330, miR-499a and LINC01133 play pivotal roles in the progression of cervical cancer in different age groups. +other 32194732 hsa-mir-3065 Uterine Cervical Neoplasms ADH7, VGLL3, CYP26B1, miR-3065, miR-330, miR-499a and LINC01133 play pivotal roles in the progression of cervical cancer in different age groups. +lncRNA target 32194725 hsa-mir-202 Carcinoma, Hepatocellular Therefore, the results from the present study suggested that miR-202 may serve as a potential target for HCC treatment. +other 32194719 hsa-mir-22 Uterine Cervical Neoplasms The current findings indicate the potential utility of miR-22 in radiotherapy for cervical cancer. +circulation_biomarker_diagnosis_up 32194703 hsa-mir-21 Pancreatic Carcinoma The results of the present study revealed that the plasma levels of exmiR-21 and exmiR-10b were upregulated in patients with PC. +exosome 32194702 hsa-mir-101 Myelodysplastic Syndromes The current study demonstrated that the expression of BM-MSC-derived EV-miR was heterogenous and based on MDS severity, the expression of EV-miR-101 was lower in high-risk group and patients with AML/MRC compared with the control and low-risk groups. The downregulation of BM-MSC-derived EV-miR-101 may be associated with cell-to-cell communication and may accelerate the malignant process in MDS cells. +genetics_knock down_promote 32194700 hsa-mir-193b Squamous Cell Carcinoma of Head and Neck Mechanistically, LINC00152 was determined to be localized in the cytoplasm and acted as a microRNA (miR)-193b-3p sponge, and LINC00152 knockdown or miR-193b-3p mimics both inhibited PI3K signaling pathway activation and downstream AKT phosphorylation; therefore, promoting TSCC progression in vitro. Overall, the results of the present study suggested that increased LINC00152 expression in TSCC tissues may act as a sponge of miR-193b-3p to promote cancer progression in vitro. +genetics_overexpression_promote 32194694 hsa-mir-21 Carcinoma, Hepatocellular Moreover, overexpression of lncRNA CASC11 led to upregulation of miR-21 in HCC cells, whereas overexpression of miR-21 had no effect on CASC11 levels. +circulation_biomarker_prognosis_up 32194691 hsa-mir-210 Glioma In conclusion, serum levels of exo-miR-210 may serve as a diagnostic, prognostic and hypoxic biomarker to reflect glioma status and hypoxic signatures. +transcription factor target 32194690 hsa-mir-107 Lung Neoplasms The results of the present study suggested that miR-107 regulates lung cancer cell proliferation and apoptosis by targeting TRIAP1. +other 32194685 hsa-mir-381 Urinary Bladder Neoplasms Therefore, EGFR-AS1 may sponge miR-381 to upregulate ROCK2 in BC, thereby promoting cell invasion and migration. +genetics_overexpression_promote 32194679 hsa-mir-124 Stomach Neoplasms Subsequent in vitro cell experiments indicated that lncRNA-ZNF281 overexpression resulted in promoting the migration and invasiveness of gastric cancer cells, while miR-124 over-expression led to its inhibition. +genetics_overexpression_suppress 32194674 hsa-mir-139 Carcinoma, Non-Small-Cell Lung 5p was significantly downregulated in NSCLC cells and tissues, and the overexpression of miR +other 32194673 hsa-mir-500a Colorectal Neoplasms In conclusion, the present study demonstrated that miR-500a may serve an oncogenic role in CRC. +transcription factor target 32194668 hsa-mir-206 Osteosarcoma Thus, miR-206 may serve as a potential target for OS treatment, in order to improve early disease diagnosis. +other 32194660 hsa-mir-744 Pancreatic Neuroendocrine Tumor The results of the present study revealed a mechanistic role for THBS2 in pNET proliferation and migration, indicating that THBS2 was downregulated by miR5p and further affected the CUX1/MMP9 cascade, which promoted the development of pNET. +other 32194644 hsa-mir-141 Triple Negative Breast Neoplasms 5p-IGF1R axis in TNBC growth and metastasis though the mechanism of competing endogenous RNAs. +genetics_knock down_promote 32194636 hsa-mir-127 Urinary Bladder Neoplasms The overexpression of miR-3127 impaired BCA cell proliferation and invasion, and the knockdown of miR-3127 enhanced BCA cell proliferation and invasion in vitro. +genetics_GWAS 32194634 hsa-mir-499 Sarcopenia Here we correlated the decrease of miR-208b, miR-499, miR-155, miR-222, miR-328, and miR-210 in sarcopenia group and non-sarcopenia group with diagnostic indexes of sarcopenia (ASM/Height2, Handgrip strength and 4-meter velocity) after adjusting sex. +genetics_GWAS 32194634 hsa-mir-28 Sarcopenia Here we correlated the decrease of miR-208b, miR-499, miR-155, miR-222, miR-328, and miR-210 in sarcopenia group and non-sarcopenia group with diagnostic indexes of sarcopenia (ASM/Height2, Handgrip strength and 4-meter velocity) after adjusting sex. +genetics_GWAS 32194634 hsa-mir-208b Sarcopenia Here we correlated the decrease of miR-208b, miR-499, miR-155, miR-222, miR-328, and miR-210 in sarcopenia group and non-sarcopenia group with diagnostic indexes of sarcopenia (ASM/Height2, Handgrip strength and 4-meter velocity) after adjusting sex. +genetics_GWAS 32194634 hsa-mir-155 Sarcopenia Here we correlated the decrease of miR-208b, miR-499, miR-155, miR-222, miR-328, and miR-210 in sarcopenia group and non-sarcopenia group with diagnostic indexes of sarcopenia (ASM/Height2, Handgrip strength and 4-meter velocity) after adjusting sex. +genetics_GWAS 32194634 hsa-mir-210 Sarcopenia Here we correlated the decrease of miR-208b, miR-499, miR-155, miR-222, miR-328, and miR-210 in sarcopenia group and non-sarcopenia group with diagnostic indexes of sarcopenia (ASM/Height2, Handgrip strength and 4-meter velocity) after adjusting sex. +genetics_GWAS 32194634 hsa-mir-21 Sarcopenia Here we correlated the decrease of miR-208b, miR-499, miR-155, miR-222, miR-328, and miR-210 in sarcopenia group and non-sarcopenia group with diagnostic indexes of sarcopenia (ASM/Height2, Handgrip strength and 4-meter velocity) after adjusting sex. +genetics_GWAS 32194634 hsa-mir-222 Sarcopenia Here we correlated the decrease of miR-208b, miR-499, miR-155, miR-222, miR-328, and miR-210 in sarcopenia group and non-sarcopenia group with diagnostic indexes of sarcopenia (ASM/Height2, Handgrip strength and 4-meter velocity) after adjusting sex. +genetics_GWAS 32194634 hsa-mir-1 Sarcopenia Here we correlated the decrease of miR-208b, miR-499, miR-155, miR-222, miR-328, and miR-210 in sarcopenia group and non-sarcopenia group with diagnostic indexes of sarcopenia (ASM/Height2, Handgrip strength and 4-meter velocity) after adjusting sex. +transcription factor target 32194626 hsa-mir-208b Schizophrenia RESULTS: Three novel schizophrenia-risk miRNAs, namely, miR-208b-3p, miR-208a-3p, and miR5p, and their targetomes converged on calcium voltage-gated channel subunit alpha1 C (CACNA1C) and B-cell lymphoma 2 (BCL2), and these are well-known contributors to schizophrenia. +transcription factor target 32194626 hsa-mir-208b Glioma RESULTS: Three novel schizophrenia-risk miRNAs, namely, miR-208b-3p, miR-208a-3p, and miR5p, and their targetomes converged on calcium voltage-gated channel subunit alpha1 C (CACNA1C) and B-cell lymphoma 2 (BCL2), and these are well-known contributors to schizophrenia. +transcription factor target 32194626 hsa-mir-208a Glioma RESULTS: Three novel schizophrenia-risk miRNAs, namely, miR-208b-3p, miR-208a-3p, and miR5p, and their targetomes converged on calcium voltage-gated channel subunit alpha1 C (CACNA1C) and B-cell lymphoma 2 (BCL2), and these are well-known contributors to schizophrenia. +transcription factor target 32194626 hsa-mir-208a Schizophrenia RESULTS: Three novel schizophrenia-risk miRNAs, namely, miR-208b-3p, miR-208a-3p, and miR5p, and their targetomes converged on calcium voltage-gated channel subunit alpha1 C (CACNA1C) and B-cell lymphoma 2 (BCL2), and these are well-known contributors to schizophrenia. +other 32194626 hsa-mir-494 Schizophrenia On the other hand, both QKI and hsa-miR5p were involved in gliomagenesis. +other 32194626 hsa-mir-494 Glioma On the other hand, both QKI and hsa-miR5p were involved in gliomagenesis. +other 32194503 hsa-mir-130a Pituitary Neoplasms In this study, we transfected miR-130a-3p mimic into the pituitary adenoma cells (GH3 cells) to investigate the function of miR-130a-3p in regulating PRL. +genetics_knock down_promote 32194406 hsa-mir-362 Urinary Bladder Neoplasms 5p, and knockdown of MBNL1-AS1 or QKI could abrogate the regulatory effects of miR +other 32194220 hsa-mir-221 Diabetes Mellitus 3p were up-regulated in the mandibles of diabetic rats and BMSCs cultured in high glucose condition. +other 32194220 hsa-mir-222 Diabetes Mellitus 3p were up-regulated in the mandibles of diabetic rats and BMSCs cultured in high glucose condition. +circRNA target 32194149 hsa-mir-3200 Stomach Neoplasms 5p/PEBP1 axis, implying that circMTO1 may become a new promising therapeutic target for GC patients. +circulation_biomarker_diagnosis_down 32194141 hsa-mir-149 Non-alcoholic Fatty Liver Disease This study aimed to research the effect of miR-149 on endoplasmic reticulum stress (ERS)-induced inflammation and apoptosis in non-alcoholic fatty liver disease (NAFLD). +circulation_biomarker_diagnosis_ns 32193503 hsa-mir-6075 Lung Neoplasms First, we used serum samples from participants with and without lung cancer to comprehensively create 2588 miRNAs profiles; next, we established a diagnostic model based on the combined expression levels of two miRNAs (miR-1268b and miR-6075) in the discovery set (208 lung cancer patients and 208 non-cancer participants). +circulation_biomarker_diagnosis_ns 32193503 hsa-mir-1268b Lung Neoplasms First, we used serum samples from participants with and without lung cancer to comprehensively create 2588 miRNAs profiles; next, we established a diagnostic model based on the combined expression levels of two miRNAs (miR-1268b and miR-6075) in the discovery set (208 lung cancer patients and 208 non-cancer participants). +circRNA target 32193155 hsa-mir-942 Uterine Cervical Neoplasms 5p to upregulate AKT1 and promote CC progression, which may offer a new molecular target for the treatment improvement of CC. +lncRNA target 32193151 hsa-mir-185 Esophageal Neoplasms Collectively, this study indicated that lncRNA KLF3-AS1 inhibited ESCC cell invasion and migration by impairing miR +circRNA target 32192854 hsa-mir-890 Glioma CONCLUSION: Our results suggested that hsa_circ_0008225 functions as a tumor inhibitor in glioma by sponging miR-890 and then promoting the function of ZMYND11. +lncRNA target 32192774 hsa-mir-198 Ovarian Neoplasms We further demonstrated that Circ0004390 may promote cell proliferation by acting as a sponge for the miR-198 family to regulated the MET expression in ovarian cancer cells. Our findings suggested that Circ0004390 regulated ovarian cancer proliferation by miR-198/MET axis, which might provide a potential target for the treatment of ovarian cancer. +other 32192599 hsa-mir-29a Polycystic Ovary Syndrome The micro-RNAs miR-29a-5p and miR-320 were found to be significantly associated with PCOS. Receiver operating characteristic analysis with an area under the curve value of 0.95 proved miR-29a-5p to be the better diagnostic marker of PCOS. +lncRNA target 32192507 hsa-mir-484 Stomach Neoplasms CONCLUSION: These data demonstrated that miR-484 can serve as a potential prognostic biomarker and therapeutic target for gastric cancer and it may be involved in the progression of gastric cancer. +other 32192453 hsa-mir-23a Lymphoma, Large B-Cell, Diffuse The Cox model including miR-146a, miR-155, miR-21, miR-34a, and miR-23a~miR-27a~miR2 cluster performed the best and successfully stratified GCB-DLBCL patients into high- and low-risk of disease progression. +other 32192453 hsa-mir-34a Lymphoma, Large B-Cell, Diffuse The Cox model including miR-146a, miR-155, miR-21, miR-34a, and miR-23a~miR-27a~miR2 cluster performed the best and successfully stratified GCB-DLBCL patients into high- and low-risk of disease progression. +other 32192453 hsa-mir-155 Lymphoma, Large B-Cell, Diffuse The Cox model including miR-146a, miR-155, miR-21, miR-34a, and miR-23a~miR-27a~miR2 cluster performed the best and successfully stratified GCB-DLBCL patients into high- and low-risk of disease progression. +other 32192453 hsa-mir-27a Lymphoma, Large B-Cell, Diffuse The Cox model including miR-146a, miR-155, miR-21, miR-34a, and miR-23a~miR-27a~miR2 cluster performed the best and successfully stratified GCB-DLBCL patients into high- and low-risk of disease progression. +other 32192453 hsa-mir-21 Lymphoma, Large B-Cell, Diffuse The Cox model including miR-146a, miR-155, miR-21, miR-34a, and miR-23a~miR-27a~miR2 cluster performed the best and successfully stratified GCB-DLBCL patients into high- and low-risk of disease progression. +other 32192453 hsa-mir-146a Lymphoma, Large B-Cell, Diffuse The Cox model including miR-146a, miR-155, miR-21, miR-34a, and miR-23a~miR-27a~miR2 cluster performed the best and successfully stratified GCB-DLBCL patients into high- and low-risk of disease progression. +transcription factor target 32191629 hsa-mir-25 Cognition Disorders 3p blocks sevoflurane-induced learning and memory impairments by inhibiting Nupr1 and the downstream C/EBPbeta/IGFBP5 signaling axis in neonatal rats. +lncRNA target 32191537 hsa-mir-335 Carcinoma, Hepatocellular The interaction among FOXD3-AS1, miR-335, and RICTOR provides a novel insight for understanding the molecular mechanism of HCC, and FOXD3-AS1, miR-335, and RICTOR can be regarded as the potential targets for HCC treatment. +other 32191528 hsa-mir-889 Uterine Cervical Neoplasms 3p had a low expression and SIX1 had a high expression in CC tissues and cells. +other 32191497 hsa-mir-28 Melanoma Conclusions: LUADT1 in melanoma and may sponge miR5p to upregulate RAP1B, thereby promoting cancer cell proliferation. +circulation_biomarker_diagnosis_up 32191117 hsa-mir-21 Pulmonary Disease, Chronic Obstructive Of these miRNAs, serum EV miR-21 was upregulated in CLD patients on DOL28 compared with levels at birth and downregulated in non-CLD patients on DOL28 compared with levels at birth. +lncRNA target 32190895 hsa-mir-27a Ovarian Neoplasms According to our knowledge, we first reported the regulation of miR-27a in hypoxia-induced chemoresistance in OC, providing a possible target for chemoresistance treatment of OC. +other 32190766 hsa-mir-27a Gastrointestinal Neoplasms MicroRNA-27a is a well-known oncogene that plays a significant role in various GI cancers. +lncRNA target 32190742 hsa-mir-205 Colorectal Neoplasms CONCLUSION: Long non-coding RNA ZEB1-AS1 silencing could inhibit cell proliferation and induce apoptosis of colorectal cancer via regulating miR-205 and YAP1. +transcription factor target 32190682 hsa-mir-124 Acute Lung Injury The involvement of MSCs-CM in lipopolysaccharide-induced acute lung injury cell model could be related to the downregulation of miR5p on alpha-ENaC, which may provide a new target for the treatment of acute lung injury. +lncRNA target 32190652 hsa-mir-124-1 Carcinoma, Ductal, Breast CONCLUSION: Our findings indicated that hsa-mir-124 expressions were associated with overall survival, TNM stages, pathologic characteristics, and tumor molecular phenotype in BRCA via TCGA_BRCA database, providing a new biomarker and a potential therapeutic target for BRCA patients. +lncRNA target 32190652 hsa-mir-124 Carcinoma, Ductal, Breast CONCLUSION: Our findings indicated that hsa-mir-124 expressions were associated with overall survival, TNM stages, pathologic characteristics, and tumor molecular phenotype in BRCA via TCGA_BRCA database, providing a new biomarker and a potential therapeutic target for BRCA patients. +other 32190622 hsa-mir-494 Spinal Cord Injuries Among them, miR-494, XIST and other genes were differentially expressed in SCI patients, and played an active regulatory role in dysfunction module, and these genes were recognized as the driving genes of SCI. +transcription factor target 32190292 hsa-mir-140 Cardiotoxicity 5p may be a novel target for treating BVZ-induced cardiotoxicity. +transcription factor target 32190292 hsa-mir-140 Cardiomyopathy, Hypertrophic Moreover, VEGFA suppression enhanced HCM injury stimulated by BVZ and partially reversed the functional role of the miR +genetics_overexpression_promote 32190151 hsa-mir-490 Carcinoma, Hepatocellular 3p overexpression could inhibit HCC cell migration and invasion, while AURKA promoted HCC cell migration. +other 32190150 hsa-mir-195 Carcinoma, Hepatocellular CONCLUSIONS: SNHG1 may promote cell invasion and migration in HCC cells by sponging miR-195. +lncRNA target 32190086 hsa-mir-16-1 Breast Neoplasms CONCLUSION: Our research provides an important basis that AE induces BT cell apoptosis through upregulation of miR-15a/miR1 that suppresses BCL2. +lncRNA target 32190086 hsa-mir-15a Breast Neoplasms CONCLUSION: Our research provides an important basis that AE induces BT cell apoptosis through upregulation of miR-15a/miR1 that suppresses BCL2. +genetics_overexpression_promote 32190006 hsa-mir-26a Squamous Cell Carcinoma of Head and Neck Overexpression of miR-26a and miR-26b inhibited TSCC cell cycle, migration invasion and glycolysis, while promoted cell apoptosis. +genetics_overexpression_promote 32190006 hsa-mir-26b Squamous Cell Carcinoma of Head and Neck Overexpression of miR-26a and miR-26b inhibited TSCC cell cycle, migration invasion and glycolysis, while promoted cell apoptosis. +lncRNA target 32190005 hsa-mir-376c Stomach Neoplasms Follow-up mechanism tests unveiled that circPIP5K1A bound with miR-376c-3p and inhibition of miR-376c-3p reversed circPIP5K1A downregulation-mediated effect on GC progression. +genetics_knock down_promote 32190004 hsa-mir-29 Glioma CONCLUSION: CircPITX1 knockdown reduced glycolysis to contribute to radiosensitivity in glioma through miR +lncRNA target 32190002 hsa-mir-545 Carcinoma, Non-Small-Cell Lung CONCLUSION: Circ_0072083 depletion contributed to DDP-triggered inhibition of NSCLC tumor through miR +genetics_overexpression_promote 32190000 hsa-mir-93 Stomach Neoplasms 5p or overexpression of AHNAK could suppress the migration and invasion abilities, in addition to EMT in GC cells via inactivation of the Wnt signaling pathway. +lncRNA target 32189969 hsa-mir-29b Ovarian Neoplasms CONCLUSION: Our findings suggest that TUG1, through targeting miR-29b-3p, induces autophagy and consequently results in PTX resistance in ovarian cancer. +lncRNA target 32189968 hsa-mir-599 Esophageal Squamous Cell Carcinoma CONCLUSION: HIPK3 can regulate the proliferation of esophageal squamous cell carcinoma cells by regulating miR-599/c-MYC axis, thereby inhibiting the occurrence and development of esophageal squamous cell carcinoma. +lncRNA target 32189967 hsa-mir-629 Osteosarcoma CONCLUSION: All experimental results demonstrated that miR-629 as an oncogene promotes the tumor cell growth, migration and invasion of OS, and miR-629 may act as a novel prognostic biomarker and therapeutic target for patients with this malignant tumor. +genetics_knock down_promote 32189593 hsa-mir-124 Depression CONCLUSION: Knockdown of miR-124 can improve depression-like behavior in CUMS-induced depressive rats, which may be related at least in part to the up-regulation of CREB1 and BDNF expression in the hippocampus. +lncRNA target 32189153 hsa-mir-589 Breast Neoplasms The present study aimed to investigate whether LncRNA ZFAS1 could regulate the proliferation, invasion and migration of breast cancer cells by targeting miR-589 through PTEN/PI3K/AKT signal pathway. In conclusion, this study indicated that ZFAS1 inhibited the proliferation, invasion and migration of breast cancer cells by targeting miR-589 through regulating the PTEN/PI3K/AKT signal pathway. +other 32188880 hsa-mir-21 Spinal Injuries First, we suggest a putative role for miR-21 in the microglial spinal injury response. +lncRNA target 32188582 hsa-mir-195 Aortic Valve Disease CONCLUSIONS: On all accounts, miR-195 can potentially inhibit aortic valve calcification by repressing VWF and p38-MAPK signaling pathway, highlighting a theoretical basis for pharmacological treatment of CAVD. +circRNA target 32188476 hsa-mir-1287 Hepatitis B, Chronic 5p/FSTL1 axis regulated HBV-induced immune suppression. +genetics_overexpression_promote 32188465 hsa-mir-19b Sepsis Overexpression of miR-19b-3p alleviated sepsis-induced inflammatory responses. +genetics_knock down_promote 32188407 hsa-mir-372 Osteosarcoma 3p/HMGB1 regulatory loop by knockdown of miR +transcription factor target 32188381 hsa-mir-493 Prostatic Neoplasms BACKGROUND: MiR-493 promotes the proliferation of prostate cancer (PC) cells by targeting PHLPP2. CONCLUSION: MiR-493 is a potent inducer of cytotoxic autophagy that leads to prostate cancer inhibition by regulating on PHLPP2. +other 32188210 hsa-mir-4459 Hepatitis B phosphatase catalytic subunit, with Pearson correlation coefficient > 0.9, may play a critical role in hepatocellular carcinoma development, which was supported by experimental evidence. +lncRNA target 32187978 hsa-mir-29b Osteosarcoma Furthermore, ZOL treatment upregulated microRNA (miR)-29b expression; the combination with a miR-29b mimic further decreased OSA cell viability via activation of the caspase 3 pathway. Thus, ZOL-mediated enhancement of carbon-ion beam radiosensitivity may occur via miR-29b upregulation; co-treatment with the miR-29b mimic further decreased OSA cell survival. +lncRNA target 32187965 hsa-mir-539 Colorectal Neoplasms Mechanistically, SNHG3 could bind to miR-539, thereby up-regulating the expression of its target gene runt-related transcription factor 2 (RUNX2), and play an oncogenic role in CRC progression. Our works suggest that lncRNA SNHG3 promotes CRC growth and metastasis via regulating miR-539/RUNX2 axis, suggesting that the SNHG3 might be a potential therapeutic target for CRC. +lncRNA target 32187165 hsa-mir-210 Myocardial Infarction 3p/Nfkb1 feedback loop enhances hypoxia-induced cell apoptosis in MI through deactivating the PI3K/Akt pathway. +circulation_biomarker_diagnosis_up 32187107 hsa-mir-433 Myocardial Reperfusion Injury MiR-433 inhibition significantly decreased CK-MB and LDH serum level in IR rats. +circulation_biomarker_diagnosis_ns 32186933 hsa-mir-126 Diabetes Mellitus MicroRNA (miR)3p is a potential diabetes biomarker and a proangiogenic factor, and its plasma level decreases in diabetic patients. +genetics_knock down_suppress 32186927 hsa-mir-150 Ovarian Neoplasms 5p in OVCAR3 and SKOV3 cells with MIAT overexpression or knockdown, and in ovarian cancer subtypes was also measured by qRT-PCR. +lncRNA target 32186779 hsa-mir-204 Shprintzen Golberg craniosynostosis In addition, lncRNA EBLN3P regulated TMPRSS3 expression via the regulation of miR2045p in normal SGNs. +transcription factor target 32186774 hsa-mir-10a Adenocarcinoma of Lung In conclusion, miR10a suppressed the PI3K/Akt pathway to strengthen the resistance of CTCs to cisplatin via targeting PIK3CA, providing a new therapeutic target for lung cancer treatment. +lncRNA target 32186770 hsa-mir-34a Breast Neoplasms The present study aimed to investigate the association between miR34a/E2F1/E2F3 and patient survival in breast cancer, as well as the underlying molecular mechanism of miR34a in suppressing factors associated with tumor aggressiveness in vitro. +genetics_overexpression_promote 32186762 hsa-mir-744 Osteosarcoma Furthermore, it was demonstrated that ectopic overexpression of miR744 induced by a miR744 precursor significantly enhanced proliferation of the osteosarcoma cell line MG63, whereas opposite results were observed following suppression of miR744 with its inhibitor. +transcription factor target 32186752 hsa-mir-196b Glomerulonephritis, IGA The present results also suggested that miRNA196b and miRNA33a3p targeted COSMC, and that miRNA196b expression in B lymphocytes was significantly higher in the IgAN group compared with the control group (P<0.0001). Therefore, miRNA196b may play a role in the formation of GdIgA1 and IgAN pathogenesis via COSMC regulation. +genetics_overexpression_promote 32186750 hsa-mir-638 Carcinoma, Endometrioid Functional studies indicated that the overexpression of miR638 in EC cell lines inhibited in vitro tumor progression and in vivo tumorigenicity. +transcription factor target 32186675 hsa-mir-224 Retinoblastoma 3p, highly expressed in retinoblastoma, inhibited the expression of its target gene LATS2, which inhibited activation of the Hippo-YAP signaling pathway. +transcription factor target 32186283 hsa-mir-375 Heart Diseases H9c2 rat cardiac myocytes and adult murine cardiomyocytes (AMCs) were cultured in vitro and treated with doxorubicin, with and without pretreatment with miR-375 inhibitor. +circulation_biomarker_prognosis_ns 32185824 hsa-mir-125a Coronary Artery Disease METHODS A total of 280 patients with ULMCAD underwent CABG were consecutively enrolled in our prospective study, and their plasma samples were collected before CABG for the detection of lnc-NEAT1 and miR-125a expressions by reverse transcription quantitative polymerase chain reaction. +genetics_overexpression_promote 32185608 hsa-mir-6887 Squamous Cell Carcinoma of Head and Neck Functional assessment revealed that overexpression of miR +other 32185543 hsa-mir-1284 Uterine Cervical Neoplasms In this study, we have designed the CD59sp-conjugated miRNA-1284/cisplatin(CDDP)-loaded liposomes for the enhanced therapeutic effect against cervical cancers. Notably, MiR-1284 showed a typical concentration-dependent cell killing effect in the cervical cancer cells owing to the downregulation of HMGB1. +other 32185300 hsa-mir-200b Sjogren's Syndrome METHODS: At first, the miR200b-5p-expression will be examined by in situ hybridization in MSGs of pSS patients who are at low risk and have not developed NHL during follow-up, high risk and developed NHL in the future (pre-lymphoma) or have NHL, and the expressing cellular types, as well as those with reduced expression during lymphomagenesis, will be identified. +transcription factor target 32185126 hsa-mir-125a Triple Negative Breast Neoplasms Here, we studied the potential role of miR-125a-3p as a modulator of the EGFR/HER2 pathway in basal-like breast cancer. Our findings indicate that, in the basal-like subtype of breast cancer, miR-125a-3p may act as a tumor suppressor. +other 32184824 hsa-mir-493 Osteosarcoma We examined the expression of FAM64A and the upstream gene miR-493 in OS. +other 32184669 hsa-mir-143 Urinary Bladder Neoplasms CONCLUSION: Therefore, NCK1-AS1 promotes cancer cell proliferation and increases cell stemness in UBC patients by down-regulating miR-143. +other 32184662 hsa-mir-143 Uterine Cervical Neoplasms CONCLUSION: TMPO-AS1 promotes cervical cancer cell proliferation, migration, and invasion by regulating the miR3p/ZEB1 axis. +genetics_overexpression_promote 32184661 hsa-mir-155 Uterine Cervical Neoplasms MiR503HG overexpression in CSCC cells led to the suppression of miR-155 and elevation of Caspase-3, acting as the downstream target of miR-155. CONCLUSION: Therefore, miR503HG may regulate the drug resistance of CSCC cells by regulating mir-155/Caspase-3. +other 32184661 hsa-mir-503 Uterine Cervical Neoplasms INTRODUCTION: The purpose of this study is to investigate the role of long non-coding RNA (lncRNA) miR503 Host Gene (miR503HG) in cervical squamous cell carcinoma (CSCC). +circulation_biomarker_diagnosis_ns 32184642 hsa-mir-122 maturity-onset diabetes of the young type 3 Previously, we have found that the serum microRNA (miR)-122 levels in MODY3 patients were lower than those in type 2 diabetes mellitus and healthy controls. +lncRNA target 32184630 hsa-mir-342 Carcinoma, Hepatocellular 3p, providing a promising therapeutic target for HCC treatment. +circRNA target 32184627 hsa-mir-659 Breast Neoplasms CONCLUSION: Collectively, this study revealed for the first time that hsa_circ_0068033 acts as a tumor suppressor gene in BC, and the hsa_circ_0068033/miR-659 axis participates in the progression of BC. +lncRNA target 32184620 hsa-mir-6165 Stomach Neoplasms CONCLUSION: It was found that miR-6165 might suppress GC migration and invasion by targeting STRN4 in vitro, and the further research should focus more on the potential diagnosis and prognosis value of miR-6165 and STRN4 in gastric cancer patients. +lncRNA target 32184618 hsa-mir-199a Glioma MiR-199a-3p could target ZHX1 to inhibit its expression in glioma cells. +genetics_overexpression_promote 32184617 hsa-mir-148 Carcinoma, Non-Small-Cell Lung Overexpression of PVT1 was capable of promoting NSCLC cell proliferation and migration which could be reversed by miR-148 restoration or RAB34 knock down. +genetics_knock down_promote 32184614 hsa-mir-335 Uterine Cervical Neoplasms Moreover, anti-miR-335 could reverse the inhibitory effects of circ_103973 knockdown on CC cell proliferation, and this phenomenon could be blocked by si-PPP6C. +circulation_biomarker_diagnosis_ns 32184430 hsa-mir-21 Cardio-Renal Syndrome Our findings suggest that circulating miR-21 has medium diagnostic value in CRS-2. +tissue_expression_up 32184379 hsa-mir-424 Birt-Hogg-Dube Syndrome 5p and let-7d-5p by FLCN deficiency occurred in epithelial cells and marked the PSP-BHD condition, which contributed to a focused degenerative pathology in the lung of PSP-BHD patients. +tissue_expression_up 32184379 hsa-let-7d Birt-Hogg-Dube Syndrome 5p and let-7d-5p by FLCN deficiency occurred in epithelial cells and marked the PSP-BHD condition, which contributed to a focused degenerative pathology in the lung of PSP-BHD patients. +lncRNA target 32184167 hsa-let-7b Nociceptive Pain Compared with Let-7b-5p agomir EA group, the expression level of PENK in Let-7b-5p antagomir EA group was increased at days 1, 4, and 7 (p < 0.05) CONCLUSION: Let-7b-5p may be a new potential target for decreasing the EA tolerance effect and facilitating the application of EA in treating chronic nociception of patients. +genetics_knock down_suppress 32184164 hsa-mir-543 Glioblastoma Down-regulation of miR-543 elevated GBM cell malignant behaviors, which was reversed by LEF1-AS1 knockdown. The LEF1-AS1/miR-543/EN2, as a novel ceRNA network, was implicated in the progression of GBM, which provided a novel insight for GBM treatment. +genetics_overexpression_promote 32183929 hsa-mir-4792 Leukemia, Myeloid, Acute Overexpression of kindlin-3 in AML cells partially reversed the inhibitory effects of miR-4792 mimic. +genetics_overexpression_promote 32183822 hsa-mir-143 Melanoma 3p and FLOT2 overexpression rescued the inhibitory effect of miR +other 32183236 hsa-mir-7 Parkinson Disease Specifically, we used human stem cell cultures and whole zebrafish embryos to study, in vitro and in vivo, the role of miR-7 in the development of dopaminergic (DA) neurons, a cell type primarily affected in Parkinson's disease. +other 32182839 hsa-mir-21 Prostatic Neoplasms Overall, these results suggest that miR-21 plays a significant role related to Wnt-11 in the pathophysiology of PCa. +lncRNA target 32182608 hsa-mir-203 Hepatoblastoma These results provide insight into the underlying mechanisms of HB and indicate that CRNDE and miR-203 might be potential targets for HB therapy. +transcription factor target 32182570 hsa-mir-29a Duane Retraction Syndrome Taken together, these results provided a miR-29a-repressing mechanism through which OPN plays roles in abnormal synthesis of Col IV in HRCECs and resultant BM thickening, contributing to the pathogenesis of DR. +other 32182129 hsa-mir-4779 Osteosarcoma The data demonstrated that miR-4779 negatively regulates the expression of PLK1, and both miR-4779 and PLK1 regulate cell proliferation and cell apoptosis of MG63/Dox cells, processes that are involved in the drug resistance of OS cells. +lncRNA target 32182086 hsa-mir-101 Prostatic Neoplasms Rap1A was identified as a target of miR-101 and it attenuated the effect of miR-101 on Pca development. +genetics_knock down_suppress 32181994 hsa-mir-338 Pneumonia CONCLUSIONS: The current work had led to the identification of circ_0038467 knockdown that alleviated LPS-induced inflammatory injury in 16HBE cells at least partly through sponging miR3p and regulating JAK/STAT3 pathway, highlighting novel molecular targets for the treatment of pneumonia. +lncRNA target 32181973 hsa-mir-34a Leukemia, Myeloid, Acute Furthermore, inhibition of miR-34a-mediated suppression in leukemia stem cells was associated with poor clinical outcomes and impaired treatment efficacy in acute myeloid leukemia. +transcription factor target 32181582 hsa-mir-3116 Glioma In conclusion, miR-3116 sensitizes glioma cells to TMZ through FGFR1 downregulation and the PI3K/AKT pathway inactivation. +lncRNA target 32181504 hsa-mir-24 Sepsis Down-regulation of CYTOR aggravates sepsis-induced cardiac injury via regulating miR-24 and XIAP. +lncRNA target 32181504 hsa-mir-24 Cardiomyopathies Down-regulation of CYTOR aggravates sepsis-induced cardiac injury via regulating miR-24 and XIAP. +circRNA target 32181485 hsa-mir-486 Urinary Bladder Neoplasms Taken together, circRNA_0058063 functions by sponging miR3p in BC progression, which could act as a new biomarker and further developed to be a therapeutic target in BC. +other 32180907 hsa-mir-181a Leukemia, Myeloid, Acute CONCLUSIONS: MiR-181a-3p may be clinically useful as a disease marker for AML, and enhanced the prediction of patient outcomes to chemotherapy. +lncRNA target 32180557 hsa-mir-122 Carcinoma, Hepatocellular Importantly, expressions of Gls and Slc1a5 as well as glutaminase activity were suppressed in a Gln-dependent HCC (EC4) cell line transfected with miR-122 mimic that resulted in decreased (13)C-Gln, (13)C-a-ketoglutarate, (13)C-isocitrate, and (13)C-citrate levels. +other 32180557 hsa-mir-122 Congenital central hypoventilation syndrome Finally, The Cancer Genome Atlas-Liver Hepatocellular Carcinoma (TCGA-LIHC) database analysis showed that expression of GLS is negatively correlated with miR-122 in primary human HCCs, and the upregulation of GLS RNA is associated with higher tumor grade. CONCLUSIONS: Collectively, these results show that miR-122 modulates Gln metabolism both in vitro and in vivo, implicating the therapeutic potential of miR-122 in HCCs that exhibit relatively high GLS levels. +other 32180557 hsa-mir-122 Esophageal Squamous Cell Carcinoma Finally, The Cancer Genome Atlas-Liver Hepatocellular Carcinoma (TCGA-LIHC) database analysis showed that expression of GLS is negatively correlated with miR-122 in primary human HCCs, and the upregulation of GLS RNA is associated with higher tumor grade. +other 32180557 hsa-mir-122 Hypoglycemia, leucine-induced Finally, The Cancer Genome Atlas-Liver Hepatocellular Carcinoma (TCGA-LIHC) database analysis showed that expression of GLS is negatively correlated with miR-122 in primary human HCCs, and the upregulation of GLS RNA is associated with higher tumor grade. +lncRNA target 32180353 hsa-mir-210 Mouth Neoplasms This study aimed to explore new therapeutic targets to improve the survival rate of patients with oral squamous cell carcinoma (OSCC).MiR +other 32180078 hsa-mir-582 Reperfusion Injury, Cerebral Ischemia In addition, ZFAS1 could negatively regulate miR3p expression and release its effects in CIRI. +other 32180078 hsa-mir-582 Inflammation In addition, ZFAS1 could negatively regulate miR3p expression and release its effects in CIRI. +genetics_knock down_promote 32179834 hsa-mir-205 Melanoma One of them is miR-205, the loss of which contributes to the development of melanoma metastasis. +lncRNA target 32179813 hsa-mir-670 Pain 3p functions as the regulator of Igf2bp1 expression and plays a crucial role in PA development through m6A modification. +circulation_biomarker_diagnosis_down 32179735 hsa-mir-134 Depressive Disorder, Major Although limited by the relatively small sample size, these results demonstrated that plasma miR-134 displays potential ability as a biomarker for MDD. +genetics_overexpression_promote 32179410 hsa-mir-194 Leukemia, Myeloid, Acute Overexpression of either NEAT1 or miR +lncRNA target 32179097 hsa-mir-200c Nasopharyngeal Neoplasms Our results provide a novel mechanism governing c-Myc and miR-200c expression and indicate that either targeting c-Myc or restoring miR-200c expression would be a promising approach to overcome oncogenic role of c-Myc in NPC. +lncRNA target 32179078 hsa-mir-147b Tuberculosis CONCLUSION: miR-147b might regulate macrophage proliferation and migration through targeting C11orf87 via Pi3K/AKT pathway in Tuberculosis in vitro, which calls for in-depth inter-cellular researches and animal researches to further support that miR-147b/C11orf87 axis might be a potential therapeutic target for the molecular treatment of Tuberculosis in the future. +circulation_biomarker_diagnosis_down 32178730 hsa-mir-20a Diabetic Retinopathy MiR-320a was shown to be downregulated in the plasma of DR patients compared with DM patients without DR and healthy subjects. +genetics_GWAS 32178691 hsa-mir-9 Cancer Pain 5p modified BMSCs can relieve bone cancer pain via modulating neuroinflammation in the central nervous system, suggesting genetically modified BMSCs could be a promising cell therapy in pain management. +genetics_knock down_promote 32178675 hsa-mir-128 Fractures, Bone A series gain- and loss- function experiment indicated that miR +genetics_overexpression_suppress 32178301 hsa-mir-204 Melanoma In particular miR5p and miR-199b-5p were found to function as antagonists of resistance because their enforced overexpression is able to inhibit melanoma cell growth in vitro either alone or in combination with MAPKi. +genetics_overexpression_suppress 32178301 hsa-mir-199b Melanoma In particular miR5p and miR-199b-5p were found to function as antagonists of resistance because their enforced overexpression is able to inhibit melanoma cell growth in vitro either alone or in combination with MAPKi. +lncRNA target 32176822 hsa-mir-146a Periodontitis LncRNA MAFG-AS1 is predicted to interact with miR-146a, which can target Toll-like receptor 4 (TLR4), a key player in periodontitis. +circulation_biomarker_prognosis_ns 32176633 hsa-mir-532 Leukemia, Myeloid, Acute CONCLUSION: We found plasma exosome-derived microRNA-532 can be used as a novel survival predictor for acute myeloid leukemia. +genetics_knock down_promote 32176631 hsa-mir-654 Carcinoma, Hepatocellular 3p inhibited HCC cell proliferation, migration, and invasion, while knockdown of miR +genetics_knock down_suppress 32176627 hsa-mir-339 Glioblastoma CONCLUSIONS: LINC00467 knockdown repressed cell proliferation but stimulated cell apoptosis in glioblastoma via miR +lncRNA target 32176624 hsa-mir-219 Glioblastoma OBJECTIVE: With glioblastoma cell line U87 as the object, the changes in expression levels of HOTAIR and miR-219 in each group were detected via quantitative real-time polymerase chain reaction (qRT-PCR) after HOTAIR in U87 cell lines was knocked down using small interfering RNA (siRNA). CONCLUSION: HOTAIR can repress the proliferation and promote the apoptosis of glioblastoma cells by targeting miR-219. +other 32176569 hsa-mir-20a Cardiovascular Diseases miR-10a (p<0.05) was significantly associated with heart failure, while increased expression levels for miR-21 and miR-20a associated with atherosclerosis. +other 32176569 hsa-mir-21 Cardiovascular Diseases miR-10a (p<0.05) was significantly associated with heart failure, while increased expression levels for miR-21 and miR-20a associated with atherosclerosis. +other 32176569 hsa-mir-10a Cardiovascular Diseases miR-10a (p<0.05) was significantly associated with heart failure, while increased expression levels for miR-21 and miR-20a associated with atherosclerosis. +genetics_overexpression_promote 32176463 hsa-mir-200a Carcinoma, Non-Small-Cell Lung Furthermore, we find that FTX overexpression activates the expression of transcription factor FOXA2, an important regulator in lung cancer progression, and we reveal a novel FTX/miR-200a-3p/FOXA2 competing endogenous RNA regulatory axis in lung cancer cells. +other 32176411 hsa-mir-146a Periodontitis However, little is known about the biogenesis, function and mechanism of miR-146a in cementoblasts during the pathogenesis of periodontitis. +lncRNA target 32176315 hsa-mir-491 Osteoporosis, Postmenopausal CTSS, which was highly expressed in patients with PMO, was confirmed as a direct target of miR +circulation_biomarker_prognosis_up 32176034 hsa-mir-144 Small Cell Lung Carcinoma 3p along with the pathways included protein kinase B signaling, muscle structure development, Cell Cycle (Mitotic) and blood vessel development may gain a high chance to play a key role inthe prognosis of SCLC, but more studies should be conducted to reveal it more clearly. +circulation_biomarker_prognosis_up 32176034 hsa-mir-9 Small Cell Lung Carcinoma 3p along with the pathways included protein kinase B signaling, muscle structure development, Cell Cycle (Mitotic) and blood vessel development may gain a high chance to play a key role inthe prognosis of SCLC, but more studies should be conducted to reveal it more clearly. +circulation_biomarker_prognosis_up 32176034 hsa-mir-1290 Small Cell Lung Carcinoma 3p along with the pathways included protein kinase B signaling, muscle structure development, Cell Cycle (Mitotic) and blood vessel development may gain a high chance to play a key role inthe prognosis of SCLC, but more studies should be conducted to reveal it more clearly. +circulation_biomarker_prognosis_up 32176034 hsa-mir-1 Small Cell Lung Carcinoma 3p along with the pathways included protein kinase B signaling, muscle structure development, Cell Cycle (Mitotic) and blood vessel development may gain a high chance to play a key role inthe prognosis of SCLC, but more studies should be conducted to reveal it more clearly. +circulation_biomarker_prognosis_up 32176034 hsa-mir-7 Small Cell Lung Carcinoma 3p along with the pathways included protein kinase B signaling, muscle structure development, Cell Cycle (Mitotic) and blood vessel development may gain a high chance to play a key role inthe prognosis of SCLC, but more studies should be conducted to reveal it more clearly. +circulation_biomarker_prognosis_up 32176034 hsa-mir-182 Small Cell Lung Carcinoma 3p along with the pathways included protein kinase B signaling, muscle structure development, Cell Cycle (Mitotic) and blood vessel development may gain a high chance to play a key role inthe prognosis of SCLC, but more studies should be conducted to reveal it more clearly. +circulation_biomarker_prognosis_up 32176034 hsa-mir-18a Small Cell Lung Carcinoma 3p along with the pathways included protein kinase B signaling, muscle structure development, Cell Cycle (Mitotic) and blood vessel development may gain a high chance to play a key role inthe prognosis of SCLC, but more studies should be conducted to reveal it more clearly. +circulation_biomarker_diagnosis_up 32175983 hsa-mir-219 Inflammatory Bowel Diseases 5p exhibited significantly relieved histopathological changes of colon tissues, increased colon length, decreased DAI, as well as decreased serum levels of IL-6, -17A, -21, and -23 (P < 0.05). +lncRNA target 32175684 hsa-mir-7 Breast Neoplasms LINC00115 also reduces the expression of KLF4, which is a direct target of miR-7 and is involved in breast cancer metastasis. Together, our findings suggest that LINC00115 promotes breast cancer metastasis through modulating the expression of miR-7 and KLF4. +other 32175564 hsa-mir-130b Adrenocortical Carcinoma CONCLUSIONS: The present study inferred that the metastasis-related ceRNAs of H2AFX, hsa-miR-130b-3p and Macrophages M0 might play important roles in ACC metastasis. +genetics_knock down_promote 32175269 hsa-mir-15b Breast Neoplasms Knockdown of miR-15b-5p significantly increased HPSE2 expression at both mRNA and protein levels in breast cancer cells in vitro. +other 32175019 hsa-mir-21 Ovarian Neoplasms The miR-21 silencing was measured by stem-loop RT PCR in A2780 ovarian cancer cell lines whether it is sensitive to resistant to cisplatin. +genetics_overexpression_suppress 32174801 hsa-mir-485 Glioma SPIONs drive miR5p overexpression in cells and inhibit endogenous Tie1 expression to downregulate the protein expression levels of Fgf2/GDNF/GFAP/BDNF and significantly weaken the in vivo and in vitro viability of gliomas. +lncRNA target 32174796 hsa-mir-139 Stomach Neoplasms 5p and PMP22 might be important diagnostic or therapeutic targets for gastric cancer and other human diseases. +genetics_overexpression_suppress 32174262 hsa-mir-31 Triple Negative Breast Neoplasms Overexpression of miR +genetics_overexpression_promote 32174219 hsa-mir-200a Cerebral Palsy The binding site between miR-200a and Myt1L was analyzed.TCTP and Myt1L were overexpressed and miR-200a was under-expressed in CP rats. +transcription factor target 32174132 hsa-mir-524 Colonic Neoplasms 5p inhibited angiogenesis in colon cancer cells via targeting with-no-lysine kinase 1. +other 32174027 hsa-mir-101 Carcinoma, Hepatocellular RESULTS: TFB2M was commonly up-regulated in HCC mainly because of the down-regulation of miR101-3p, which significantly correlated with poor survival of HCC patients. +lncRNA target 32173992 hsa-mir-1246 Macular Degeneration CONCLUSIONS: Our results provide a mechanistic basis for evaluation of miR-1246 as a new candidate target for the clinical treatment of AMD. +other 32173991 hsa-let-7a hereditary diffuse gastric cancer Therefore, a new fluorescence analysis method for direct detection of let-7a in human gastric cancer cell samples without enzyme, label free and no immobilization was established using lucigenin/chitosan/SiO(2) composite nanoparticles as a DNA hybrid indicator. +other 32173975 hsa-mir-20a Cystoid Macular Edema, Diabetic 5p, hsa-miR-20a-5p, hsa-miR-15b-5p and hsa-miR-15a-5p) showing a fold change greater than -50 in log2 values in the miRNA PCR array were selected, all significantly down-regulated in the DMO group compared to the control group (P < .05), and showed a direct relationship with tumour necrosis factor, nuclear factor kappa B subunit 1 and interleukin-6 (IL-6) in bioinformatics analysis, all of which were related to vascular endothelial growth factor (VEGF). +other 32173975 hsa-mir-185 Cystoid Macular Edema, Diabetic 5p, hsa-miR-20a-5p, hsa-miR-15b-5p and hsa-miR-15a-5p) showing a fold change greater than -50 in log2 values in the miRNA PCR array were selected, all significantly down-regulated in the DMO group compared to the control group (P < .05), and showed a direct relationship with tumour necrosis factor, nuclear factor kappa B subunit 1 and interleukin-6 (IL-6) in bioinformatics analysis, all of which were related to vascular endothelial growth factor (VEGF). +other 32173975 hsa-mir-15a Cystoid Macular Edema, Diabetic 5p, hsa-miR-20a-5p, hsa-miR-15b-5p and hsa-miR-15a-5p) showing a fold change greater than -50 in log2 values in the miRNA PCR array were selected, all significantly down-regulated in the DMO group compared to the control group (P < .05), and showed a direct relationship with tumour necrosis factor, nuclear factor kappa B subunit 1 and interleukin-6 (IL-6) in bioinformatics analysis, all of which were related to vascular endothelial growth factor (VEGF). +other 32173975 hsa-mir-17 Cystoid Macular Edema, Diabetic 5p, hsa-miR-20a-5p, hsa-miR-15b-5p and hsa-miR-15a-5p) showing a fold change greater than -50 in log2 values in the miRNA PCR array were selected, all significantly down-regulated in the DMO group compared to the control group (P < .05), and showed a direct relationship with tumour necrosis factor, nuclear factor kappa B subunit 1 and interleukin-6 (IL-6) in bioinformatics analysis, all of which were related to vascular endothelial growth factor (VEGF). +lncRNA target 32173903 hsa-mir-28 Retinoblastoma Mechanistically, ANRIL promoted Rb cell resistance to DDP by acting as a sponge of miR-328 to upregulate expression of ABCG2, which was confirmed as a direct target of miR-328. Collectively, hypoxia-induced ANRIL promotes DDP resistance in Rb cells by sponging miR-328 to upregulate ABCG2 expression. +transcription factor target 32173733 hsa-mir-128 Depression A discernable increase in expression of amygdalar miR3p along with significant downregulation of key target genes from Wnt signaling (WNT5B, DVL, and LEF1) was noted in MDD subjects. +lncRNA target 32173634 hsa-mir-155 Brain Ischemia MicroRNA-155 is a brain-specific or brain-enriched miRNA, which mediates inflammatory reactions in cerebral ischemic tissue by regulating inflammatory signal and the expression level of SOCS1. In conclusion, GuaLou GuiZhi Decoction (GLGZD) might exert its anti-inflammatory action by inhibiting the expression of miR-155, indicating that miR-155 may be used as a treatment target in clinical treatment with GuaLou GuiZhi Decoction (GLGZD) in ischemic brain. +lncRNA target 32173492 hsa-mir-142 Inflammatory Bowel Diseases TUG1 negatively regulated inflammation in ulcerative colitis through miR5p/SOCS1 axis. +lncRNA target 32173462 hsa-mir-130a Hypoxia-Ischemia, Brain, Newborn In conclusion, H19/miR-130a-3p/DAPK1 axis regulated the pathophysiology of neonatal HIE, suggesting potential therapeutic targets for neonatal HIE treatment. +other 32172543 hsa-mir-505 Hyperlipoproteinemia Type II miR3p controls chemokine receptor up-regulation in macrophages: role in familial hypercholesterolemia. +other 32172249 hsa-mir-122 Non-alcoholic Fatty Liver Disease miRNA122-5p, miRNA34a-5p, -miRNA155-5p and miRNA146b-3p were up-regulated in NAFLD group (p < 0.05) and positively correlated with body mass index (r, 0.41-0.59), alanine aminotransferase (r, 0.36-0.52), aspartate transaminase (r, 0.31-0.48) and uric acid (UA, r, 0.51-0.69; p < 0.05). +other 32172249 hsa-mir-146b Non-alcoholic Fatty Liver Disease miRNA122-5p, miRNA34a-5p, -miRNA155-5p and miRNA146b-3p were up-regulated in NAFLD group (p < 0.05) and positively correlated with body mass index (r, 0.41-0.59), alanine aminotransferase (r, 0.36-0.52), aspartate transaminase (r, 0.31-0.48) and uric acid (UA, r, 0.51-0.69; p < 0.05). +other 32172249 hsa-mir-34a Non-alcoholic Fatty Liver Disease miRNA122-5p, miRNA34a-5p, -miRNA155-5p and miRNA146b-3p were up-regulated in NAFLD group (p < 0.05) and positively correlated with body mass index (r, 0.41-0.59), alanine aminotransferase (r, 0.36-0.52), aspartate transaminase (r, 0.31-0.48) and uric acid (UA, r, 0.51-0.69; p < 0.05). +circulation_biomarker_prognosis_ns 32172218 hsa-mir-194 Osteosarcoma CONCLUSION: In conclusion, our results have demonstrated that serum miR-194 might serve as a novel and promising biomarker for the detection and prognosis of osteosarcoma. +genetics_knock down_promote 32171324 hsa-mir-495 Squamous Cell Carcinoma of Head and Neck Subsequently, gain- and loss-function approach was performed to detect the role of miR-495 and HOXC6 in cell proliferation, migration, invasion, cell cycle entry, apoptosis, and epithelial-mesenchymal transition (EMT) of CSCs in OSCC, as well as the tumor growth in vivo. +transcription factor target 32171241 hsa-mir-34a Endomyocardial Fibrosis To examine the role of the miR-34a-ACSL4 interaction in IMF deposition in the pig, mRNA and protein expression of the ACSL4 gene was measured in primary intramuscular preadipocytes transfected with miR-34a mimic and inhibitor. +lncRNA target 32170966 hsa-mir-454 Squamous Cell Carcinoma of Head and Neck CONCLUSION: The study illustrates that miR-454 acts as an active regulator to facilitate OSCC cells growth, colony formation, invasion, and migration by targeting NR3C2, which may afford a novel perspective and possibility for the targeted treatment of OSCC. +genetics_knock down_promote 32170633 hsa-mir-145 Glioblastoma Furthermore, we found that knockdown of ADAM17 decreased activation of EGFR/Akt/C/EBP-beta signaling, and consequently upregulated miR-145 expression in GBM cell lines. +lncRNA target 32170604 hsa-mir-26a Myocardial Infarction MiR-26a-5p could target and regulate ADAM17, reduce the apoptosis of myocardial cells and the expression of inflammatory factors in acute myocardial infarction, and reduce the occurrence of oxidative stress. +transcription factor target 32170506 hsa-mir-27b Staphylococcal Scalded Skin Syndrome In contrast to model group, miR-27b inhibitor could significantly promote the healing of scalded skin, alleviate the pathological status of scalded, and promote the angiogenesis and proliferation (p < 0.05). +genetics_knock down_promote 32170433 hsa-mir-516b Lung Neoplasms Furthermore, besides, circAKT3 knockdown suppressed lung tumor cell growth by the miR-516b-5p/STAT3 axis in vivo. +transcription factor target 32170146 hsa-mir-134 Colorectal Neoplasms We found potential interactions of two miRNAs targeting EGFR expression, (miR-134 and miR-4328, in non-metastatic and metastatic tumors, respectively). EGFR expression could be regulated by amplification or polysomies (in metastatic tumors), or miRNAs (miRNA-134, in non-metastatic tumors). +other 32170105 hsa-mir-923 Stomach Neoplasms It has not been studied or reported in gastric carcinoma, so the relationship between gastric hsa-mir-3923 expression and the clinics feature and pathology of GC cases was examined. Our results elucidated that hsa-mir-3923 high-expression reveals poor prognosis of GC patients. +circulation_biomarker_prognosis_ns 32170048 hsa-mir-519d Carcinoma, Non-Small-Cell Lung MiR-519d could potentially serve as a novel serum biomarker for NSCLC. +genetics_overexpression_suppress 32169757 hsa-mir-671 Stomach Neoplasms 5p inhibitor or KRT80 overexpression could offset the inhibitory effect of circPIP5K1A depletion on GC development. +transcription factor target 32169441 hsa-mir-223 Rhinitis, Allergic 37 children with AR and 30 healthy children were enrolled to study the correlation of miR-223 and IL-35. Our study suggests the potential of miR-223 and IL-35 as a molecular target for the treatment of AR. +other 32169278 hsa-mir-140 Stomach Neoplasms For GC cells, circ-ATAD1 increased cell progression by sponging miR3p to upregulate YY1. +lncRNA target 32169117 hsa-mir-107 Melanoma mediated inhibitory effect on melanoma cells. +lncRNA target 32169098 hsa-mir-100 Acute Lung Injury Moreover, MSC-MV-transferred miR-100 mediated the therapeutic effect of MSC-MVs in ALI through enhancing autophagy by targeting mTOR. CONCLUSION: MSC-MVs enhance autophagy and ameliorate ALI partially via delivery of miR-100. +genetics_overexpression_suppress 32168859 hsa-mir-20a Acquired Immunodeficiency Syndrome At cHL diagnosis, miR-20a, miR-21 and miR-324 were overexpressed in cHL (p = 0.005, p = 0.024, and p = 0.001, respectively), while miR-223, miR-16, miR-185 and miR-106a were down regulated (p = 0.042, p = 0.007, p = 0.006, and p = 0.002, respectively). +genetics_overexpression_suppress 32168859 hsa-mir-20a Hodgkin Disease At cHL diagnosis, miR-20a, miR-21 and miR-324 were overexpressed in cHL (p = 0.005, p = 0.024, and p = 0.001, respectively), while miR-223, miR-16, miR-185 and miR-106a were down regulated (p = 0.042, p = 0.007, p = 0.006, and p = 0.002, respectively). +other 32168096 hsa-mir-205 Hyperglycemia Taken together, our data indicate that miR-205 negatively regulates the expression of Kir4.1 in astrocytes grown in hyperglycemic conditions. +lncRNA target 32168096 hsa-mir-250 Hyperglycemia Previous studies performed in a human corneal epithelial cell injury model demonstrated a mechanism of regulation of Kir4.1 expression via the binding of microRNA-250 (miR-205) to the Kir4.1 3 untranslated region. +other 32167927 hsa-mir-181b Thyroid Nodule In addition, miR-146b and miR-181b were recognized as biomarkers for discriminating benign thyroid nodules from malignant ones. +other 32167927 hsa-mir-146b Thyroid Nodule In addition, miR-146b and miR-181b were recognized as biomarkers for discriminating benign thyroid nodules from malignant ones. +genetics_overexpression_suppress 32167655 hsa-mir-542 Carcinoma, Ovarian Epithelial 3p overexpression inhibited malignant progression of ovarian cancer cells. +genetics_knock down_promote 32167539 hsa-mir-760 Stomach Neoplasms Moreover, miR-760 overexpression and knockdown were conducted in gastric cancer cells (MGC-803 and SGC-7901) in vitro. +genetics_overexpression_suppress 32166986 hsa-mir-103a Prostatic Neoplasms Interestingly, overexpression of TPD52 significantly attenuated the effect of mir-103a-3p on PCa. +genetics_overexpression_promote 32166887 hsa-mir-765 Stomach Neoplasms In addition, down-regulation of miRNA-765 increased the sensitivity of GC cells to anticancer drugs, whereas its overexpression had the opposite effect. +genetics_GWAS 32166848 hsa-mir-34b Hepatoblastoma RESULTS: Single loci analysis showed that neither TP53 rs1042522 C>G, nor miR-34b/c rs4938723 T>C significantly modified hepatoblastoma risk. +genetics_GWAS 32166848 hsa-mir-34c Hepatoblastoma RESULTS: Single loci analysis showed that neither TP53 rs1042522 C>G, nor miR-34b/c rs4938723 T>C significantly modified hepatoblastoma risk. +circulation_biomarker_prognosis_down 32166472 hsa-mir-602 Ischemic Stroke The elevation of S100B and downregulation of circulating miR-602 in the sera of ischemic stroke (IS) patients: the emergence of novel diagnostic and prognostic markers. +circulation_biomarker_diagnosis_up 32166120 hsa-mir-224 Carcinoma, Hepatocellular RESULTS: The relative expression of serum miRNA-224 was significantly higher in HCC patients compared to LC patients and healthy control subjects. +circulation_biomarker_prognosis_up 32165937 hsa-mir-146a Epilepsy CONCLUSION: Our findings suggest that up-regulated plasma miR-106b and miR-146a could be used as biomarkers for epilepsy evaluation. +circulation_biomarker_prognosis_up 32165937 hsa-mir-106b Epilepsy CONCLUSION: Our findings suggest that up-regulated plasma miR-106b and miR-146a could be used as biomarkers for epilepsy evaluation. +other 32165822 hsa-mir-181a Keratoconus Further, the XIST-miR-181a-COL4A1 axis might be implicated in the pathogenesis of KC. +transcription factor target 32165673 hsa-mir-146 Thyroid Cancer, Papillary Further study demonstrated that CTC modulated the progression and chemoresistance of PTC cells via miR-146 and KIT. The analysis of hundreds of clinical specimens revealed that CTC and KIT levels were downregulated, whereas miR-146 levels were greater in PTC tissues than in normal thyroid. +circulation_biomarker_prognosis_up 32165595 hsa-mir-29 Glomerulonephritis, IGA RESULTS Relative plasma expression of miR-29a in patients with IgAN was significantly lower than that in healthy controls (P < .001), and these changes in plasma miR-29a could be suppressed by treatment (P < .05). +circulation_biomarker_prognosis_up 32165595 hsa-mir-29a Glomerulonephritis, IGA RESULTS Relative plasma expression of miR-29a in patients with IgAN was significantly lower than that in healthy controls (P < .001), and these changes in plasma miR-29a could be suppressed by treatment (P < .05). +other 32165252 hsa-mir-26a Liver Diseases In line with known miR-26a functions, this RG4 can regulate hepatic insulin sensitivity and lipid metabolism in vitro and in vivo. +transcription factor target 32165252 hsa-mir-26a-1 Obesity Obesity leads to the formation of these RG4 structures in pre-miR-26a-1 molecules, impairing the maturation and function of miR-26a, which has emerged as a therapeutic target in several diseases. +other 32165252 hsa-mir-26a-1 Liver Diseases In line with known miR-26a functions, this RG4 can regulate hepatic insulin sensitivity and lipid metabolism in vitro and in vivo. +transcription factor target 32165252 hsa-mir-26a Obesity Obesity leads to the formation of these RG4 structures in pre-miR-26a-1 molecules, impairing the maturation and function of miR-26a, which has emerged as a therapeutic target in several diseases. +circulation_biomarker_diagnosis_up 32165186 hsa-let-7b Endometriosis Two serum microRNAs showed significantly lower levels in the endometriosis group: miR5p and let-7b. +circulation_biomarker_diagnosis_up 32165186 hsa-mir-613 Endometriosis Two serum microRNAs showed significantly lower levels in the endometriosis group: miR5p and let-7b. +tissue_expression_ns 32165090 hsa-mir-155 Breast Neoplasms We evaluated expression of two rate limiting enzymes from this pathway (IDO1 and TDO2) as well as three long non-coding RNAs (lncRNAs) that have been predicted to alter expression of IDO1 (ITGB2-AS1, HCP5 and MIR155HG) in 82 breast cancer tissues and their adjacent non-cancerous tissues (ANCTs). +transcription factor target 32164324 hsa-mir-143 Colorectal Neoplasms We analyzed the expression and the functional role of some c-MYC linked miRNAs (miR3p, miR-143 and miR-145) in our patient group and in two CRC cell lines, also performing a c-MYC target PCR array. +transcription factor target 32164324 hsa-mir-145 Colorectal Neoplasms We analyzed the expression and the functional role of some c-MYC linked miRNAs (miR3p, miR-143 and miR-145) in our patient group and in two CRC cell lines, also performing a c-MYC target PCR array. +genetics_knock down_suppress 32163895 hsa-mir-101 Squamous Cell Carcinoma of Head and Neck 3p was physically bound to RC3H2 as well as EZH2, and its inhibitor reversed the inhibitory effect of RC3H2 knockdown on progression of OSCC. +transcription factor target 32163390 hsa-mir-455 Carcinoma, Hepatocellular Studies have shown that miR-455 plays a regulatory role in the development of HCC. In conclusion, our study indicates that miR-455 plays a suppressive role in HCC development by targeting RhoC-encoding mRNA. +other 32163372 hsa-mir-596 Ovarian Neoplasms CONCLUSION: RHPN1-AS1-miRLETM1 axis plays a crucial role in EOC progression. +transcription factor target 32163190 hsa-mir-125a Demyelinating Diseases These findings show that miR-125a-3p upregulation negatively affects OPC maturation in vivo, suggest its role in the pathogenesis of demyelinating diseases and unveil new targets for future promyelinating protective interventions. +genetics_knock down_promote 32162890 hsa-mir-34a Leukemia, Myeloid, Acute The expression level of miR-34a in initial treatment AML group was negatively correlated with the number of bone marrow primary immature cells, but not with the number of peripheral blood leukocytes, platelet count, hemoglobin content, age, gender, and chromosomal abnormalities. +circulation_biomarker_diagnosis_ns 32162885 hsa-mir-148a Liver Injury The correlation between circulating miR-148a-3p and liver injury after operation was analyzed using Pearson's correlation assay. +lncRNA target 32162877 hsa-mir-587 Acute Coronary Syndrome CONCLUSIONS: The expression of platelet miR-587 was closely related to the severity of coronary artery stenosis and could be used as a potential target for diagnosis or prognosis. +lncRNA target 32162294 hsa-mir-497 Myocardial Infarction ET reduced the infarct size in MI rats and inhibited the levels of miR-497. +other 32162175 hsa-mir-497 Leukemia, Myeloid, Acute The present study aimed to explore Tanshinone IIA (TIIA) effects on OCI-AML3 and the involvement of the MAPK signaling pathway and miR-497 in TIIA-mediated effects. TIIA upregulates miR-497, and decrease the p-ERK1/2 expression, when TIIA simulated OCI-AML3 cell in vitro. +other 32162171 hsa-mir-500b Myocardial Infarction In the MI group, the expression levels of circMACF1 and EMP1 were decreased with the increasing expression level of miR-500b-5p. CircMACF1 impaired the progression of AMI by modulating the miR-500b-5p/EMP1 axis. +other 32162011 hsa-mir-200c Squamous Cell Carcinoma of Head and Neck CONCLUSION: Our results suggest that the miR-200c might be a potential prognostic biomarker for OSCC. +lncRNA target 32161722 hsa-mir-34a Sarcoma, Ewing Furthermore, systemic administration of nCAR/miR-34a-5p dramatically suppressed the ES xenograft tumor growth in vivo while showing biocompatibility. +lncRNA target 32161621 hsa-mir-125b Carcinoma, Squamous Cell, Cutaneous CONCLUSIONS: Our findings indicate that miR-125b acts as a tumor suppressor in CSCC by targeting the STAT3 pathway. +other 32161621 hsa-mir-125 Carcinoma, Squamous Cell, Cutaneous BACKGROUND: MicroRNA-125b (miR-125b) is downregulated in human cutaneous squamous cell carcinoma (CSCC). +genetics_overexpression_promote 32161468 hsa-mir-766 Osteosarcoma Ectopic overexpression of circ_0001105 or YTHDF2 significantly suppressed OS cell viability and invasion through regulating miR-766. +genetics_knock down_promote 32161467 hsa-mir-485 Uterine Cervical Neoplasms 5p inhibitor could partially reverse the effects on CC cells induced by SNHG7 knockdown. +transcription factor target 32161448 hsa-mir-346 Myocardial Reperfusion Injury RESULTS: We found that miRNAs sequencing analysis showed the expressions of 15 types of miRNAs, including miR-346, were downregulated and 29 types of miRNAs were elevated in the MIRI rat model. CONCLUSION: This study revealed a novel pathway, miR-346/Bax axis, in the regulation of apoptosis in MIRI and which might be a new molecular mechanism and therapeutic target. +transcription factor target 32160960 hsa-mir-499 Diabetic Retinopathy 3p promoted retinal cell proliferation while suppressing apoptosis to alleviate diabetic retinopathy. +circulation_biomarker_diagnosis_up 32160957 hsa-mir-126 Cerebral Hemorrhage Further, the MSCs (transfected with lentivirus expressing microRNA-126a-3p (miR-126)) were injected into the type collagenase-induced ICH rats to investigate the recovery effects of blood-brain barrier (BBB) and nerve damage in vivo. +circulation_biomarker_diagnosis_up 32160957 hsa-mir-126a Cerebral Hemorrhage Further, the MSCs (transfected with lentivirus expressing microRNA-126a-3p (miR-126)) were injected into the type collagenase-induced ICH rats to investigate the recovery effects of blood-brain barrier (BBB) and nerve damage in vivo. +other 32160777 hsa-mir-126 Venous Thrombosis 5p. +other 32160777 hsa-mir-194 Venous Thrombosis 5p. +other 32160777 hsa-mir-192 Venous Thrombosis 5p. +other 32160777 hsa-mir-885 Venous Thrombosis 5p. +lncRNA target 32160771 hsa-mir-152 Heart Failure Finally, a proof-of-concept of the therapeutic efficacy of targeting miR-152 in vivo was obtained by utilizing a locked nucleic acid-based inhibitor of miR-152 (LNA 152) in a murine model of HF subjected to transverse aortic constriction. +lncRNA target 32160712 hsa-mir-221 Breast Neoplasms Collectively, our findings reveal that GAS5 exerted regulatory function in ADR resistance possibly through the miR3p/DKK2 axis, providing a novel approach to develop promising therapeutic strategy for overcoming chemoresistance in breast cancer patients. +genetics_overexpression_suppress 32160707 hsa-mir-19a Leukemia, Myelogenous, Chronic, BCR-ABL Positive Targeting PCBP1, FUS protein, miR-19a-3p, and miR-106b-5p significantly inhibits the cell growth and colony formation of CML cell lines. Co-overexpression of H19 and PCBP1, FUS, miR-19a-3p, and miR-106b-5p decreases the inhibitory effect of H19 in CML. +genetics_overexpression_suppress 32160707 hsa-mir-106b Leukemia, Myelogenous, Chronic, BCR-ABL Positive Targeting PCBP1, FUS protein, miR-19a-3p, and miR-106b-5p significantly inhibits the cell growth and colony formation of CML cell lines. Co-overexpression of H19 and PCBP1, FUS, miR-19a-3p, and miR-106b-5p decreases the inhibitory effect of H19 in CML. +transcription factor target 32160705 hsa-mir-20b Cardiomegaly In conclusion, pro-hypertonic miR-20b plays crucial roles in cardiac hypertrophy through downregulation of Mfn2 and cytosolic Ca(2+) overload by weakening the buffering capability of mitochondria. +lncRNA target 32160703 hsa-mir-20a Carcinoma, Hepatocellular The tumor suppressor effect of miR-20a could be demonstrated even in this rapid-onset HRAS(G12V)/c-MYC HCC model, consistent with significantly prolonged survival and decreased HCC tumor burden. +lncRNA target 32160475 hsa-mir-760 Myocardial Reperfusion Injury Taken together, these findings suggest that miR-760 inhibits the protective effect of NaHS against MIRI. +lncRNA target 32160394 hsa-mir-29c Parkinson Disease Our previous study showed that miR-29c-3p (miR-29c) exhibited anti-inflammatory properties in PD animal and neuronal models. Thus, these findings suggest that miR-29c modulates NLRP3 inflammasome to impair microglial inflammatory responses by targeting NFAT5, which represents a promising therapeutic target for PD. +genetics_overexpression_promote 32160014 hsa-mir-223 Adenocarcinoma of Lung Besides, overexpression of MORT inhibited, whereas overexpression of miRNA-223 promoted the invasion and migration of LUAD cells. +other 32159972 hsa-mir-451 Asthma These data demonstrate a role for miR-451 in modulating allergic inflammation by influencing allergen-mediated macrophages phenotype. +genetics_overexpression_promote 32159887 hsa-mir-219 Carcinoma, Non-Small-Cell Lung 3p inhibited cell growth, migration and invasion, and reversed EMT, just like the role of XB130 in NSCLC cells, whereas the suppressive effects of microRNA (miRNA) overexpression were weakened by miRNA inhibitors or ectopic expression of XB130 in NSCLC cells. +genetics_overexpression_promote 32159887 hsa-mir-219 Lung Neoplasms 3p inhibited cell growth, migration and invasion, and reversed EMT, just like the role of XB130 in NSCLC cells, whereas the suppressive effects of microRNA (miRNA) overexpression were weakened by miRNA inhibitors or ectopic expression of XB130 in NSCLC cells. +genetics_overexpression_promote 32159887 hsa-mir-4782 Carcinoma, Non-Small-Cell Lung 3p inhibited cell growth, migration and invasion, and reversed EMT, just like the role of XB130 in NSCLC cells, whereas the suppressive effects of microRNA (miRNA) overexpression were weakened by miRNA inhibitors or ectopic expression of XB130 in NSCLC cells. +genetics_overexpression_promote 32159887 hsa-mir-4782 Lung Neoplasms 3p inhibited cell growth, migration and invasion, and reversed EMT, just like the role of XB130 in NSCLC cells, whereas the suppressive effects of microRNA (miRNA) overexpression were weakened by miRNA inhibitors or ectopic expression of XB130 in NSCLC cells. +genetics_overexpression_promote 32159887 hsa-mir-203 Carcinoma, Non-Small-Cell Lung 3p inhibited cell growth, migration and invasion, and reversed EMT, just like the role of XB130 in NSCLC cells, whereas the suppressive effects of microRNA (miRNA) overexpression were weakened by miRNA inhibitors or ectopic expression of XB130 in NSCLC cells. +genetics_overexpression_promote 32159887 hsa-mir-203 Lung Neoplasms 3p inhibited cell growth, migration and invasion, and reversed EMT, just like the role of XB130 in NSCLC cells, whereas the suppressive effects of microRNA (miRNA) overexpression were weakened by miRNA inhibitors or ectopic expression of XB130 in NSCLC cells. +genetics_GWAS 32159700 hsa-mir-17 Periapical Diseases This study evaluated the association between polymorphisms in genes encoding estrogen receptors 1 (ESR1) and 2 (ESR2), vitamin D receptor (VDR) and in microRNA17 (which binds to ESR1 and VDR) with persistent apical periodontitis (PAP) after the endodontic treatment. In conclusion, the genetic polymorphisms in ESR1, ESR2, VDR and miRNA17 are not associated with PAP. +circRNA target 32159361 hsa-mir-128 Diabetes Mellitus Therefore, these findings advocate targeting the mmu_circ_0000250/miR3p/SIRT1 axis as a candidate therapeutic option for diabetic ulcers. +other 32159312 hsa-mir-34a Stomach Neoplasms Normal mucosa can be distinguished from gastric cancer only by miRNA-34a, -21, -375. +other 32159312 hsa-mir-20a Precancerous Conditions All miRNAs, except miRNA-20a, were included in the decision tree, which allows stratification of samples for normal mucosa, dysplasia, and gastric cancer. +other 32159312 hsa-mir-34a Precancerous Conditions Normal mucosa can be distinguished from gastric cancer only by miRNA-34a, -21, -375. +other 32159312 hsa-mir-20a Stomach Neoplasms All miRNAs, except miRNA-20a, were included in the decision tree, which allows stratification of samples for normal mucosa, dysplasia, and gastric cancer. +lncRNA target 32159255 hsa-mir-1249 Colonic Neoplasms CONCLUSIONS: miR-1249 exerts a suppressive effect on cell proliferation, migration and invasion in COAD, which is possibly achieved via modulating FJX1. +genetics_overexpression_suppress 32159247 hsa-mir-299 Squamous Cell Carcinoma of Head and Neck Furthermore, USP48 was conspicuously overexpressed in HNSCC cells and capable of binding with miR +genetics_knock down_promote 32159214 hsa-mir-27a Ovarian Neoplasms Finally, it was also observed that knockdown of FBXW7 by si-FBXW7 reversed the tumor suppressive activity of APS in OC cells, which is similar to the effects of miR-27a overexpression. +lncRNA target 32158694 hsa-mir-665 Carcinoma, Non-Small-Cell Lung The MGST1, MGST3, GST-omega1, and ABCG2 mRNAs, miR5p and miR-665 miRNAs, and MSTRG51053.2 and PPAN lncRNAs can serve as potential DDP drug targets to reverse DDP resistance in NSCLC. +epigenetics 32158519 hsa-mir-21 Signs and Symptoms 5p/miR-217 carried by SEN sEVs spread pro-senescence signals, affecting DNA methylation and cell replication. +epigenetics 32158519 hsa-mir-217 Signs and Symptoms 5p/miR-217 carried by SEN sEVs spread pro-senescence signals, affecting DNA methylation and cell replication. +genetics_overexpression_promote 32158359 hsa-mir-181b Glioblastoma RESULTS: MiR-181b overexpression significantly reduced the glucose metabolic and colony formation ability of GBM cells. +genetics_overexpression_promote 32158357 hsa-mir-338 Colorectal Neoplasms Conclusion These findings highlighted the fact that overexpression of hsa_circ_0137008 inhibited the progression of CRC via sponging miR +circulation_biomarker_prognosis_up 32158234 hsa-mir-191 Stomach Neoplasms CONCLUSION: Up-regulated expression of miR-191 and miR-425 in the serum of patients with advanced GC are effective biomarkers for the diagnosis, chemotherapy and prognosis evaluation of GC. +circulation_biomarker_prognosis_up 32158234 hsa-mir-425 Stomach Neoplasms CONCLUSION: Up-regulated expression of miR-191 and miR-425 in the serum of patients with advanced GC are effective biomarkers for the diagnosis, chemotherapy and prognosis evaluation of GC. +genetics_knock down_promote 32158227 hsa-mir-204 Esophageal Squamous Cell Carcinoma CONCLUSION: SNHG1 knockdown suppresses migration and invasion but induces apoptosis of esophageal squamous cell cancer cells by increasing miR-204 and decreasing HOXC8. +lncRNA target 32157950 hsa-mir-885 Asthma Conclusion: The findings of this study demonstrated that VDR is an miR-885 target, while the presence of rs739837 minor allele (T) in miR-885 interferes with the interaction between miR-885 and VDR to affect the severity of asthma. +lncRNA target 32157707 hsa-mir-744 Leukemia, Myeloid, Acute Furthermore, we characterized YY1 as the direct target of miR +other 32157550 hsa-mir-3960 Squamous Cell Carcinoma of Head and Neck Meanwhile, miR-3960 increased the relative mRNA expression of TIM3 in HNSCC cells. +circulation_biomarker_diagnosis_ns 32157513 hsa-mir-21 Breast Neoplasms We studied the levels microRNA (miR-21, miR-221, miR-222, and miR-429) in blood serum, thoracic duct lymph, and breast cancer tissue, as well as the cell composition of the axillary lymph node in Wistar female rats with chemically induced breast cancer. +circulation_biomarker_diagnosis_ns 32157513 hsa-mir-221 Breast Neoplasms We studied the levels microRNA (miR-21, miR-221, miR-222, and miR-429) in blood serum, thoracic duct lymph, and breast cancer tissue, as well as the cell composition of the axillary lymph node in Wistar female rats with chemically induced breast cancer. +circulation_biomarker_diagnosis_ns 32157513 hsa-mir-222 Breast Neoplasms We studied the levels microRNA (miR-21, miR-221, miR-222, and miR-429) in blood serum, thoracic duct lymph, and breast cancer tissue, as well as the cell composition of the axillary lymph node in Wistar female rats with chemically induced breast cancer. +circulation_biomarker_diagnosis_ns 32157513 hsa-mir-429 Breast Neoplasms We studied the levels microRNA (miR-21, miR-221, miR-222, and miR-429) in blood serum, thoracic duct lymph, and breast cancer tissue, as well as the cell composition of the axillary lymph node in Wistar female rats with chemically induced breast cancer. +genetics_knock down_suppress 32157498 hsa-mir-342 Pancreatic Carcinoma 3p in pancreatic cancer cells with OIP5-AS1 knockdown. +lncRNA target 32157373 hsa-mir-4458 Melanoma Mechanical interaction of miR-4458 and PBX3 mRNA, thereby inhibiting PBX3 expression in melanoma cells, was also presented in this work. +lncRNA target 32157348 hsa-mir-1 Cardiomegaly Taken together, our study showed that a novel Tincr-miR5p axis targeting PRKCE was involved in cardiomyocyte hypertrophy, indicating that it may provide potential therapy in cardiomyocyte hypertrophy. +exosome 32157304 hsa-mir-19a Hepatitis C Monocyte exosomes from coinfected persons increased in microRNA (miR)-19a, miR-221, and miR-223, all of which were associated with decreasing inflammation and nuclear factor-kappaB activation. +exosome 32157304 hsa-mir-223 Hepatitis C Monocyte exosomes from coinfected persons increased in microRNA (miR)-19a, miR-221, and miR-223, all of which were associated with decreasing inflammation and nuclear factor-kappaB activation. +exosome 32157304 hsa-mir-223 Acquired Immunodeficiency Syndrome Monocyte exosomes from coinfected persons increased in microRNA (miR)-19a, miR-221, and miR-223, all of which were associated with decreasing inflammation and nuclear factor-kappaB activation. +exosome 32157304 hsa-mir-221 Acquired Immunodeficiency Syndrome Monocyte exosomes from coinfected persons increased in microRNA (miR)-19a, miR-221, and miR-223, all of which were associated with decreasing inflammation and nuclear factor-kappaB activation. +exosome 32157304 hsa-mir-221 Hepatitis C Monocyte exosomes from coinfected persons increased in microRNA (miR)-19a, miR-221, and miR-223, all of which were associated with decreasing inflammation and nuclear factor-kappaB activation. +exosome 32157304 hsa-mir-19a Acquired Immunodeficiency Syndrome Monocyte exosomes from coinfected persons increased in microRNA (miR)-19a, miR-221, and miR-223, all of which were associated with decreasing inflammation and nuclear factor-kappaB activation. +lncRNA target 32157216 hsa-mir-135b Carcinoma, Hepatocellular These findings strongly suggest that the LINC01352-miR-135b-APC axis regulated by the HBx/ERalpha complex acts as an important pathogenic factor for tumour progression, which may help provide a theoretical basis for the identification of new therapeutic targets for HBV-related HCC. +lncRNA target 32157211 hsa-mir-200b Thyroid Neoplasms According to TCGA data, the tumor suppressor miR-200b is overedited in thyroid tumors, and its levels of editing correlate with a worse progression-free survival and disease stage. We confirmed miR-200b overediting in thyroid tumors and we showed that edited miR-200b has weakened activity against its target gene ZEB1 in thyroid cancer cells, likely explaining the reduced aggressiveness of ADAR1-silenced cells. +lncRNA target 32156832 hsa-mir-223 Venous Thrombosis Taken together, this study indicates that GUSBP5-AS modulates angiogenesis, proliferation and homing ability of EPCs via regulating FGF2 and MMP2/9 expression through the miR +lncRNA target 32156775 hsa-mir-497 Carcinoma, Squamous Cell, Cutaneous SIGNIFICANCE: This study provides preclinical evidence for the use of miR-30c-2*/miR-497 delivery and AURKA inhibition in the treatment of cuSCC, which currently has no FDA-approved targeted therapies.See related commentary by Parrales and Iwakuma, p. +lncRNA target 32156642 hsa-mir-335 Nasopharyngitis 5p inhibits the activation of AKT signaling pathway by negatively mediating TPX2, which may confer anti-inflammatory protection in CRS. +lncRNA target 32156248 hsa-mir-619 Carcinoma, Hepatocellular 5p inhibited MKL1 expression in HCC cells by acting on its 3'-UTR. +other 32155950 hsa-mir-369 osteogenesis imperfecta type 1 5p are enriched during WOI. +other 32155950 hsa-mir-34c Rift Valley Fever Further, we integrated the RIF's database analysis results and found out that miR-34c-5p regulates growth arrest specific 1 (GAS1) for normal embryo implantation. +other 32155950 hsa-mir-34c osteogenesis imperfecta type 1 5p are enriched during WOI. +other 32155950 hsa-mir-210 osteogenesis imperfecta type 1 5p are enriched during WOI. +lncRNA target 32155539 hsa-mir-146a Drug Resistant Epilepsy OBJECTIVE: The aim of this study was to evaluate single nucleotide variants (SNVs) n.-411A > G (rs57095329) and n.60 G > C (rs2910164) in microRNA (miR)-146a, related to suppressing of TRAF6 with risk for epilepsy, as well as miR-146a and TRAF6 levels. CONCLUSIONS: The GC genotype for SNV rs2910164 appears associated with susceptibility to drug-resistant epilepsy due to the decreased MIR146a expression, favoring NF-kB pathway through TRAF6. +lncRNA target 32155348 hsa-mir-3118 Liver Neoplasms Conclusions: HAND2-AS1 enhanced inactivation of the JAK-STAT pathway through sponging miR-3118 and facilitating SOCS5 to retard cell proliferation and migration in liver cancer. +virus_miRNA 32155300 ebv-mir-BART13 Nasopharyngeal Carcinoma Circulating Epstein-Barr virus microRNAs BART7-3p and BART13-3p as novel biomarkers in nasopharyngeal carcinoma +virus_miRNA 32155300 ebv-mir-BART7 Nasopharyngeal Carcinoma Circulating Epstein-Barr virus microRNAs BART7-3p and BART13-3p as novel biomarkers in nasopharyngeal carcinoma +other 32155285 hsa-mir-210 Reperfusion Injury, Hepatic Ischemia CONCLUSIONS: Our study implicates a crucial role of miRSMAD4 interaction in hepatic IR-induced cell death and provides a promising therapeutic approach for liver IR injury. +lncRNA target 32155139 hsa-mir-142 Osteosarcoma The present study assessed the mechanism of lncRNA MSC-AS1 in OS biological features and sensitivity to cisplatin (DDP) by binding to miR-142. CONCLUSIONS Our study demonstrated that silencing MSC-AS1 inhibited OS biological behaviors by enhancing miR-142 to decrease CDK6 and inactivating the PI3K/AKT axis. +other 32154827 hsa-mir-148b Prostatic Neoplasms We observed a positive correlation between the expression of miR-148b-3p and the expression of PSA and PCA3 genes, two established biomarkers in PCa. +circulation_biomarker_diagnosis_ns 32154708 hsa-mir-21 Uterine Cervical Neoplasms The proposed assay was successfully applied to detect simultaneously miRNA-122, miRNA-155, and miRNA-21 in serum samples from healthy persons and cervical cancer patients, and the results were then compared with those of quantitative real-time-polymerase chain reaction amplification. +circulation_biomarker_diagnosis_ns 32154708 hsa-mir-155 Uterine Cervical Neoplasms The proposed assay was successfully applied to detect simultaneously miRNA-122, miRNA-155, and miRNA-21 in serum samples from healthy persons and cervical cancer patients, and the results were then compared with those of quantitative real-time-polymerase chain reaction amplification. +circulation_biomarker_diagnosis_ns 32154708 hsa-mir-122 Uterine Cervical Neoplasms The proposed assay was successfully applied to detect simultaneously miRNA-122, miRNA-155, and miRNA-21 in serum samples from healthy persons and cervical cancer patients, and the results were then compared with those of quantitative real-time-polymerase chain reaction amplification. +transcription factor target 32154600 hsa-mir-211 Lysosomal Storage Diseases Pharmacological restoration of lysosomal biogenesis through Ezrin inhibition rescued the miR-211(-/-) phenotype, pointing to a new therapeutic target to counteract retinal degeneration associated with lysosomal dysfunction. +transcription factor target 32154600 hsa-mir-211 Retinal Degeneration Pharmacological restoration of lysosomal biogenesis through Ezrin inhibition rescued the miR-211(-/-) phenotype, pointing to a new therapeutic target to counteract retinal degeneration associated with lysosomal dysfunction. +lncRNA target 32154571 hsa-mir-1258 Thyroid Cancer, Papillary Furthermore, we affirmed that miR-1258 can directly target TMPRSS4, and miR-1258 can reduce the biological malignant behaviour of PTC cells via regulation of TMPRSS4. +other 32154226 hsa-mir-29c Esophageal Neoplasms CONCLUSION: MiR-29c-3p plays a regulatory role in EC tumorigenesis and development. +lncRNA target 32154175 hsa-mir-1323 Adenocarcinoma of Lung Conclusion: The miR-1323 promoted LUAD migration through inhibiting Cbl-b expression. +circRNA target 32154171 hsa-mir-661 Glioma In addition, inhibition of miR-661 promoted glioma cell metastasis and suppressed cell apoptosis. +lncRNA target 32154166 hsa-mir-206 Colorectal Neoplasms Conclusions: MIR4435-2HG promoted CRC growth and metastasis through miR-206/YAP1 axis and is likely to play prognostic marker roles and be therapeutically targeted in CRC. +other 32154160 hsa-mir-4444-2 Colonic Neoplasms However, miR2 did not influence the migratory ability and proliferation of CA cell. +other 32153636 hsa-mir-145 Colorectal Neoplasms 3p and PPIA, and hsa-miR-378d and YY1 might be novel and potential biomarkers in improving the diagnosis of CRC. +other 32153636 hsa-mir-1 Colorectal Neoplasms 3p and PPIA, and hsa-miR-378d and YY1 might be novel and potential biomarkers in improving the diagnosis of CRC. +transcription factor target 32153570 hsa-mir-124 Inflammatory Bowel Diseases Taken together, these results suggest that nicotine shifts the balance of Th1/Th2 toward Th1 via a miR +other 32153557 hsa-mir-146a Dermatomyositis Conclusions: Reduced miR-146a expression in PM/DM leads to increased REG3A expression that increases inflammatory macrophage migration, which may be a possible underlying mechanism of DM/PM pathogenesis. +other 32153557 hsa-mir-146a Polymyositis Conclusions: Reduced miR-146a expression in PM/DM leads to increased REG3A expression that increases inflammatory macrophage migration, which may be a possible underlying mechanism of DM/PM pathogenesis. +exosome 32153518 hsa-mir-10a Encephalomyelitis, Enzootic Porcine Together, the findings demonstrated that the abundant miR-10a-5p leads to downstream suppression of SDC1, and it functions as an antiviral mechanism in the PHEV-induced disease, providing a potential strategy for the prevention and treatment of PHEV infection in the future work. +lncRNA target 32153123 hsa-mir-206 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: LncRNA SNHG14 contributed to NSCLC progression through miR-206/G6PD axis, providing novel clues for understanding the mechanism of NSCLC. +lncRNA target 32152961 hsa-mir-625 Uterine Cervical Neoplasms Our study characterized the suppressive expression of miR +lncRNA target 32152938 hsa-mir-502 Subarachnoid Hemorrhage CDKN1B was the gene that could inhibit SAH caused by apoptosis in nerve cells and inflammation by sponging miR5p and regulating factors in PPARgamma/NF-kappaB signaling pathway, suggesting it could be a factor for protecting functions of nerve cells after SAH. +genetics_knock down_suppress 32152380 hsa-mir-335 Amyotrophic Lateral Sclerosis 5p, which has an effect on mitophagy, autophagy and apoptosis in SH-SY5Y neuronal cells could have a role in the motor neuron loss observed in ALS. +lncRNA target 32152275 hsa-mir-100 Carcinoma, Hepatocellular LncRNA RAET1K silencing significantly suppressed HCC cell proliferation and invasion and also suppressed hypoxia-induced increases in lactate concentration and glucose uptake, while miR +transcription factor target 32152265 hsa-mir-143 Bone Diseases Thus, miR-143 promotes angiogenesis coupling with osteoblast differentiation by targeting HDAC7, which may serve as a potential target in angiogenic and osteogenic diseases. +genetics_knock down_promote 32151944 hsa-mir-33a Carcinoma, Non-Small-Cell Lung And miR-33a-5p inhibition could rescue the suppressive effect of circCCDC66 knockdown on NSCLC progression. +other 32151743 hsa-mir-223 Diabetes Mellitus SIGNIFICANCE: Regulation of the miR-223 level may be a novel strategy for clinical treatment of diabetes. +lncRNA target 32151743 hsa-mir-223 Hypotension Studies with Western blot, patch clamp, and perfused mesenteric arterial rings showed that transfection of miR-223 downregulated K(ATP) protein expression, inhibited K(ATP) channel activity and enhanced vasoconstriction. +lncRNA target 32151711 hsa-mir-22 Glioblastoma 3p had mutual suppression on the expression of each other in GBM cells. +other 32151690 hsa-mir-28 Aortic Aneurysm, Abdominal 5p/GRIA4/LYPD3 in VSMC apoptosis, exerting its potential in providing new thoughts in AAA management. +other 32151564 hsa-mir-637 Osteoporosis, Postmenopausal This study aimed to evaluate the expression profiles of sera miRNA-208a-3p, miRNA5p, and miRNA-637, to examine relation to osteoporosis and suggest the possible mechanisms of action to be used as innovative biomarkers for the diagnosis of osteoporosis among pre- and postmenopausal females. +other 32151564 hsa-mir-155 Osteoporosis, Postmenopausal This study aimed to evaluate the expression profiles of sera miRNA-208a-3p, miRNA5p, and miRNA-637, to examine relation to osteoporosis and suggest the possible mechanisms of action to be used as innovative biomarkers for the diagnosis of osteoporosis among pre- and postmenopausal females. +other 32151564 hsa-mir-208a Osteoporosis, Postmenopausal This study aimed to evaluate the expression profiles of sera miRNA-208a-3p, miRNA5p, and miRNA-637, to examine relation to osteoporosis and suggest the possible mechanisms of action to be used as innovative biomarkers for the diagnosis of osteoporosis among pre- and postmenopausal females. +lncRNA target 32151238 hsa-mir-199a Parkinson Disease Transfection of an miR-199a mimic increased miR-199a expression and induced all of the following: the expression levels of PTEN, GSK3beta, Beclin1, and LC3II decreased; the expression levels of phosphorylated AKT and mTOR proteins expression increased; PC12 autophagy decreased; and cellular viability and survival rates increased.Discussion: In this in vitro study, we found that increasing miR-199a expression in PC12 cells reduced protein levels of Beclin1 and LC3II, decreased autophagy, enhanced cellular viability, increased survival rate, and ameliorated MPP(+)-induced parkinsonian-like cellular pathologies by targeting pro-autophagic pathways and GSK3beta to activate PTEN/AKT/mTOR signaling. +genetics_overexpression_promote 32151175 hsa-mir-24 Thyroid Cancer, Papillary 5p is overexpressed in papillary thyroid carcinoma (PTC) with lymph node metastasis and promotes malignant phenotypes of KTC-1 cell line. +genetics_overexpression_promote 32151082 hsa-mir-361 Uterine Cervical Neoplasms We detected a reduction of miR-361 expression in CC tissues compared with normal tissues, and miR-361 overexpression inhibited invasion and EMT phenotypes of CC cells by directly targeting a key EMT activator HSP90. +genetics_overexpression_promote 32150671 hsa-mir-152 Glioma Overexpression of miR +transcription factor target 32150531 hsa-mir-216a Brain Injuries, Traumatic CONCLUSIONS In conclusion, we found that BDNF-mediated MSCs-Exo can better promote neurogenesis and inhibit apoptosis than MSCs-Exo in rats after TBI, and the mechanism may be related to the high expression of miR-216a-5p. +transcription factor target 32150490 hsa-mir-190b Angelman Syndrome AS-Exo-mediated transfer of miR-190b attenuated OGD-induced neuronal apoptosis via suppressing autophagy. +genetics_overexpression_promote 32150340 hsa-mir-20b Diabetic Retinopathy The DR rat models were established by streptozotocin injection and treated with miR-20b-3p mimics, silenced, or overexpressed thioredoxin-interacting protein (TXNIP). +lncRNA target 32150333 hsa-mir-574 Pre-Eclampsia Our results showed that the down-regulated expression of lncRNA AGAP2-AS1 might serve as a key suppressor in PE via inhibition of JDP2 at the post-transcriptional level by competing for miR-574; thus, this presents a novel therapeutic strategy for PE. +genetics_overexpression_suppress 32150250 hsa-mir-19b Endophthalmitis Moreover, overexpression of miR-19b repressed p-STAT3 expression and the number of CD11c+ cells in AC eye and CLN tissues. +genetics_overexpression_suppress 32150250 hsa-mir-19b Conjunctivitis, Allergic Moreover, overexpression of miR-19b repressed p-STAT3 expression and the number of CD11c+ cells in AC eye and CLN tissues. +lncRNA target 32150149 hsa-mir-181b Inflammation MiR-181b depletion abolished the inhibitory effects of SNHG1 intervention on the ROS generation, inflammation and apoptosis and the promoting impact on the viability of HT22 cells. +other 32150044 hsa-mir-24 Reperfusion Injury 5p are reported to have a detrimental role in ischemia-reperfusion injury. +other 32150044 hsa-mir-145 Reperfusion Injury 5p are reported to have a detrimental role in ischemia-reperfusion injury. +other 32149930 hsa-mir-34c Ischemic Stroke Further analysis demonstrated that the expression levels of miR-34b and miR-34c were also downregulated in the individuals carrying rs4938723 CC genotype by contrast with that carrying TT TC genotypes (P < 0.05). +genetics_GWAS 32149930 hsa-mir-34b Ischemic Stroke OBJECTIVES: Polymorphisms in microRNA genes are related to the risk of ischemic stroke, but the association between miR-34b/c polymorphisms and the risk of ischemic stroke has not been reported. CONCLUSION: Our study showed a positive relation between the miR-34b/c rs4938723 polymorphism and the risk of ischemic stroke, which indicated that rs4938723 may be used for ischemic stroke prediction or therapy in the future. +other 32149762 hsa-mir-34a Fibrosis The present study aimed to evaluate the effects of miR-34a-5p (miR-34a)-modified MSC-MVs on transforming growth factor (TGF)-beta1-induced fibrosis and apoptosis in vitro. +other 32149111 hsa-mir-200a Wilms Tumor We found that high expression of 8 DELs (LINC00473, AL445228.2, DENND5B-AS1, DLEU2, AC123595.1, AC135178.1, LINC00535, and LMO7-AS1) and 4 DEMs (CEP55, DEPDC1, PHF19, and TRIM36) correlated with poor survival in a patient with WT, whereas high expression of 2 DELs (MEG3 and RMST), 1 DEM (KIAA0922), and 1 DEMi (hsa-mir-200a) could possibly lead to better clinical outcomes. +lncRNA target 32149101 hsa-mir-200a Nasopharyngeal Carcinoma Additionally, miR-200a expression was suppressed and CD47 expression increased in both clinical NPC tissues and cell lines. +exosome 32149094 hsa-mir-215 Hyperglycemia Mechanistically, we confirmed that ADSCs-Exos mediated the shuttling of miR +lncRNA target 32149094 hsa-mir-251 Hyperglycemia 5p inhibitor counteracted the improvement from the ADSCs-Exo preparation on HG-induced proliferation inhibition and migration promotion. +other 32149094 hsa-mir-879 Kidney Diseases 5p, and miR-7a-5p, all of which were rescued by the addition of ADSCs-Exo. +other 32149094 hsa-mir-879 Hyperglycemia 5p, and miR-7a-5p, all of which were rescued by the addition of ADSCs-Exo. +other 32149094 hsa-mir-251 Kidney Diseases 5p, and miR-7a-5p, all of which were rescued by the addition of ADSCs-Exo. +lncRNA target 32148656 hsa-mir-206 Myocardial Infarction In vivo study, we revealed that inhibition of miR-206 in senescent MSCs could effectively protect their potential for myocardial infarction treatment in a rat MI model. +other 32148496 hsa-mir-217 Colorectal Neoplasms Our findings indicate that EGF induces EMT in colorectal cancer cells by activating FAK, and miR-217 is involved in the EGF/FAK/E-cadherin signaling pathway. +circulation_biomarker_prognosis_up 32148236 hsa-mir-24 Ischemic Stroke CONCLUSIONS: The down-regulated expressions of serum miR-24 and miR-29b are correlated with the severity degree of neurological impairment and neural function prognosis of elderly AIS patients, and the two combined have certain value for predicting the neural function prognosis of elderly AIS patients. +circulation_biomarker_prognosis_up 32148236 hsa-mir-29b Ischemic Stroke CONCLUSIONS: The down-regulated expressions of serum miR-24 and miR-29b are correlated with the severity degree of neurological impairment and neural function prognosis of elderly AIS patients, and the two combined have certain value for predicting the neural function prognosis of elderly AIS patients. +transcription factor target 32148011 hsa-mir-543 Ovarian Neoplasms To sum up, miR-543 may promote OC cell proliferation and invasion by targeting TWIST1. +transcription factor target 32147957 hsa-mir-9 Venous Thrombosis Acting as a potential therapeutic target, miR5p may play an important role in the prognosis of DVT. +other 32147957 hsa-mir-9 Thrombosis The aim of this study was to explore the role of the miR5p in regulation of the proliferation, migration and angiogenesis of EPCs and the subsequent therapeutic role in thrombosis event. +other 32147945 hsa-mir-101 Carcinoma, Non-Small-Cell Lung 3p. +lncRNA target 32147678 hsa-mir-345 Stomach Neoplasms In conclusion, miR-345 plays an inhibitory role in GC metastasis through inhibiting cell migration, EMT, and cancer stem cell phenotype via inactivation of Rac1 signaling by targeting EPS8, which provides the potential therapeutic and predictive value of miR-345 in GC. +genetics_knock down_promote 32147429 hsa-mir-448 Thyroid Cancer, Papillary Down-regulation of miR-448 followed by KDM5B knockdown reversed the effect of decreased KDM5B on the proliferation inhibition and apoptosis promotion of PTC cells. +lncRNA target 32147387 hsa-mir-34a Acute Lung Injury CONCLUSION: Collectively, we demonstrate that sevoflurane reduces inflammatory factor expression, increases lung cell viability and inhibits lung cell apoptosis in ALI through upregulation of miR-34a-3p and downregulation of STAT1, which provides new clues for ALI treatment. +circulation_biomarker_diagnosis_up 32147308 hsa-mir-21 Autoimmune Pancreatitis CONCLUSIONS: Circulating EVs exhibited altered miRNA expression patterns with elevated miR +exosome 32147195 hsa-mir-1268a Scleroderma, Diffuse 3p, 512-3p -TFDP2 in IL-23, AMPK and NOTCH signaling pathways. +exosome 32147195 hsa-mir-299 Scleroderma, Diffuse 3p, 512-3p -TFDP2 in IL-23, AMPK and NOTCH signaling pathways. +lncRNA target 32146708 hsa-mir-577 Colorectal Neoplasms Rescue experiments revealed that inhibiting miR-577 or restoring HSP27 could abrogate the effects of LINC00520 silencing on malignant phenotypes of CRC. LINC00520 functioned as an oncogenic lncRNA in CRC, and it facilitated CRC progression by regulating the miR-577/HSP27 axis, suggesting that the LINC00520/miR-577/HSP27 axis is an effective target in anticancer management. +other 32146564 hsa-mir-106a Colorectal Neoplasms MiR-26a, miR-106a and miR-181a were obviously higher in CRC tissues than in normal tissues, while PTEN was downregulated in CRC tissues. +other 32146564 hsa-mir-181a Colorectal Neoplasms MiR-26a, miR-106a and miR-181a were obviously higher in CRC tissues than in normal tissues, while PTEN was downregulated in CRC tissues. +other 32146564 hsa-mir-26a Colorectal Neoplasms MiR-26a, miR-106a and miR-181a were obviously higher in CRC tissues than in normal tissues, while PTEN was downregulated in CRC tissues. +transcription factor target 32146479 hsa-mir-18a Leukemia Therefore, miR-18a inhibitor can be of therapeutic importance for the treatment of leukemia. +lncRNA target 32146419 hsa-mir-221 Endometrial Hyperplasia In conclusion, KCNQ1OT1 attenuated intimal hyperplasia by suppressing the inflammation and proliferation of VSMCs, in which the mechanism upregulated IkappaBa expression by binding to the IkappaBa protein and sponging miR-221. +transcription factor target 32146367 hsa-mir-382 Pneumonia 5p inhibition, subsequently triggered pulmonary inflammation. +genetics_overexpression_promote 32145584 hsa-mir-132 Pulmonary Disease, Chronic Obstructive Moreover, rescue assays demonstrated that PTEN suppression (or miR-132 overexpression) attenuated the effects of SNHG5 upregulation on COPD progression. +other 32145470 hsa-mir-150 Colitis In addition, the expression of inflammatory genes and colonic TJP were also associated with the restoration of miRNAs (miR-150, miR-155, miR-223) in B. +other 32145470 hsa-mir-155 Colitis In addition, the expression of inflammatory genes and colonic TJP were also associated with the restoration of miRNAs (miR-150, miR-155, miR-223) in B. +lncRNA target 32145360 hsa-mir-133b Cicatrix RESULTS: Intravenous delivery of miR133b and/or Ago2 targeted the microenvironment at the lesion site and prevented the increased expression of certain extracellular matrix proteins (ECM), in particular collagen type 1 alpha 1 and tenascin N, which are known to have a key role in scar formation. +lncRNA target 32145360 hsa-mir-133b Spinal Cord Injuries STUDY DESIGN: This is an experimental animal study of acute SCI, investigating the effect of miR133b on spinal cord recovery by targeting scar lesion formation. +lncRNA target 32145360 hsa-mir-133b Stroke STUDY DESIGN: This is an experimental animal study of acute SCI, investigating the effect of miR133b on spinal cord recovery by targeting scar lesion formation. +other 32145360 hsa-mir-133b Spinal Cord Diseases They first investigated the level of miR133b in the spinal cord and in spinal cord lesion after a single dose of injection. +transcription factor target 32145290 hsa-mir-410 Diabetic Cardiomyopathies In conclusion, our study demonstrated that miR5p might be involved in the progression of DCM by targeting PIM1 and might be a promising therapeutic target for DCM in the future. +circulation_biomarker_diagnosis_ns 32145274 hsa-mir-338 Pancreatic Carcinoma CONCLUSION Circulating miR3p and miR-199b-5p are correlated to the neutrophil count in the blood of PDAC patients, suggesting a potential role of circulating miRNAs in cancer immune evasion and systemic inflammation. +circulation_biomarker_diagnosis_ns 32145274 hsa-mir-199b Pancreatic Carcinoma CONCLUSION Circulating miR3p and miR-199b-5p are correlated to the neutrophil count in the blood of PDAC patients, suggesting a potential role of circulating miRNAs in cancer immune evasion and systemic inflammation. +other 32145274 hsa-mir-28 Pancreatic Carcinoma 3p, miR-1258 and miR-199b-5p were upregulated in high compared to low SII patients (fold difference 2, P<0.05). +genetics_GWAS 32145124 hsa-mir-1253 Medulloblastoma Deregulation of miR-1253 expression was noted, both in medulloblastoma clinical samples and cell lines, by epigenetic silencing via hypermethylation; specific de-methylation of miR-1253 not only resulted in rapid recovery of expression but also a sharp decline in tumor cell proliferation and target gene expression. +genetics_overexpression_promote 32144736 hsa-mir-485 Breast Neoplasms Overexpressing MUC1 while overexpressing miR +other 32144602 hsa-mir-489 Fibrosis 3p was remarkably decreased while JAG1 was increased in liver fibrosis models both in vivo and in vitro. +genetics_overexpression_promote 32144351 hsa-mir-21 Glioma A multivariate Cox regression analysis of the miR-21 expression in the TCGA glioma dataset revealed that overexpression of miR-21 was a potential independent prognostic biomarker of poorer OS (HR = 1.27, 95% CI: 1.01, 1.59) and poorer PFS (HR = 1.46, 95% CI: 1.17, 1.82). +genetics_knock down_promote 32144238 hsa-mir-93 Colorectal Neoplasms In conclusion, HOTAIR knockdown potentiated radiosensitivity through regulating miR-93/ATG12 axis in CRC, further elucidating the roles and molecular basis of HOTAIR in CRC radioresistance. +genetics_overexpression_suppress 32144236 hsa-mir-450a Colorectal Neoplasms Moreover, SOX2 overexpression preserved the miR-450a-5p-induced inhibition of CRC properties, angiogenesis, and VM. +lncRNA target 32143869 hsa-mir-146a Reperfusion Injury Taken together, these data indicated that miR-146a protect against hepatic IRI via inhibiting TLR4 signaling pathway. +genetics_GWAS 32143722 hsa-mir-873 Colorectal Neoplasms CONCLUSIONS: SNP rs12982687 was involved in smoking-triggered CRC progression, given its influence on UCA1's binding with miR +genetics_overexpression_promote 32143670 hsa-mir-7 Breast Neoplasms RESULTS: MiR-7 was expressed at low levels in breast cancer tissues compared with normal tissues, and overexpression of miR-7 directly inhibited lncRNA XIST, which mediates the transcriptional silencing of genes on the X chromosome, and reduced epithelium-specific antigen (ESA) expression by increasing miR-92b and inhibiting slug. +genetics_overexpression_suppress 32143670 hsa-mir-92b Breast Neoplasms RESULTS: MiR-7 was expressed at low levels in breast cancer tissues compared with normal tissues, and overexpression of miR-7 directly inhibited lncRNA XIST, which mediates the transcriptional silencing of genes on the X chromosome, and reduced epithelium-specific antigen (ESA) expression by increasing miR-92b and inhibiting slug. CONCLUSIONS: The findings from this study uncover the molecular mechanisms by which miR-7 inhibits XIST, modulates the miR-92b/Slug/ESA axis, and decreases the RELA and CD44 expression, resulting in a reduced BCSC subset and breast cancer growth inhibition. +other 32142919 hsa-mir-24 Rhabdomyosarcoma 5p show anti-oncogenic and anti-metastatic potential, thereby opening up the possibility of being used as novel therapeutic tools to avoid RMS progression. +genetics_knock down_promote 32142918 hsa-mir-6778 Stomach Neoplasms 5p or SHMT1 notably mitigates GCSC sphere formation and increases sensitivity to 5-fluorouracil in Drosha-knockdown gastric cancer cells. +circulation_biomarker_diagnosis_ns 32142864 hsa-mir-124 Brain Injuries, Traumatic Our findings indicate that the extent of lateral fluid-percussion injury-induced chronic cortical pathology associated with the acutely elevated plasma miR +transcription factor target 32142853 hsa-mir-28 Colorectal Neoplasms 3p may inhibit proliferation and metastasis of CRC cells by targeting Girdin and inactivating the PI3K/Akt signaling pathway. +genetics_GWAS 32142478 hsa-mir-148a Carcinoma, Hepatocellular Whereas overexpression of miR-148a-5p can reverse IRFA-induced migration of HCC cells and upregulation of Snail, mechanistically overexpression of miR-148a-5p can directly target and decrease the expression of protein kinase ATM (ataxia telangiectasia mutated), which can increase protein stability of Snail. +genetics_GWAS 32142098 hsa-mir-146a Breast Neoplasms The single nucleotide polymorphism (SNP) rs2910164, located in the seed region of miR146a, was shown to be associated with BC among different populations. +other 32141990 hsa-mir-4286 Angelman Syndrome In conclusion, our study first demonstrated that miR-4286/TGF-beta1/Smad3-negative feedback loop ameliorated vascular endothelial cell damage by attenuating apoptosis and inflammatory response, providing new thoughts for promoting the treatment of AS. +circulation_biomarker_diagnosis_down 32141790 hsa-mir-106b Alzheimer Disease Taken together, detection of serum miR-106b might be a promising serum biomarker for early diagnosis of AD. +circulation_biomarker_diagnosis_up 32141587 hsa-mir-20a Diabetes Mellitus RESULTS: Serum levels of blood glucose and markers of renal function were significantly lower, and the lipid profile improved in the miR-20a mimic group compared to the DA group. +circulation_biomarker_diagnosis_up 32141587 hsa-mir-20a Diabetic Angiopathies RESULTS: Serum levels of blood glucose and markers of renal function were significantly lower, and the lipid profile improved in the miR-20a mimic group compared to the DA group. +genetics_overexpression_suppress 32141571 hsa-mir-223 Thrombophlebitis MATERIALS AND METHODS: The rat model of thrombophlebitis was established, and miR-223 was silenced or overexpressed through lentiviral transfection. CONCLUSIONS: The overexpression of miR-223 can inhibit the TLR signaling pathway, thereby promoting the recovery of thrombophlebitis rats. +lncRNA target 32141566 hsa-mir-135a Diabetic Nephropathies Finally, Western blotting results manifested that the protein levels of Notch, NIC, and Hes1 in the renal tissues of rats in DM group were considerably higher than those in Control group (p<0.05), and that their protein expression levels in miR-135a inhibitor group were markedly lower than those in DM group (p<0.05). +lncRNA target 32141566 hsa-mir-135a Fibrosis, Renal Finally, Western blotting results manifested that the protein levels of Notch, NIC, and Hes1 in the renal tissues of rats in DM group were considerably higher than those in Control group (p<0.05), and that their protein expression levels in miR-135a inhibitor group were markedly lower than those in DM group (p<0.05). +lncRNA target 32141564 hsa-mir-99 Atherosclerosis CONCLUSIONS: These results revealed the underlying mechanism that ANRIL promoted AS progression by sponging miR5p and regulating RAS/RAF/ERK signal pathway, suggesting that ANRIL might be a potential target for the therapeutic strategy of AS. +genetics_overexpression_promote 32141561 hsa-mir-29b Glioma As expected, the effect of miR-29b upregulation on cell growth and apoptosis of TMZ-resistant glioma cells was reversed by STAT3 overexpression. +genetics_knock down_suppress 32141560 hsa-mir-181a Breast Neoplasms Furthermore, the knockdown of miRNA-181a partially reversed the effect of AK024094 on cellular behaviors of BCa cells. +other 32141559 hsa-mir-411 Breast Neoplasms 5p and enhancing VASP expression, providing essential biomarkers for BC therapy. +lncRNA target 32141558 hsa-mir-515 Breast Neoplasms 5p was downregulated in BC tissues and cells and worked as a target of hsa_circ_0008039. +genetics_knock down_promote 32141554 hsa-mir-374b Carcinoma, Non-Small-Cell Lung Both knockdown of MALAT1 and miR-374b-5p overexpression inhibited proliferation, migration and invasion and induced apoptosis in NSCLC cells. +genetics_overexpression_promote 32141553 hsa-mir-20a Lung Neoplasms Elevated LIMK1 could abolish the overexpression of miR-320a induced effects on lung cancer cells. +lncRNA target 32141548 hsa-mir-192 Colonic Neoplasms 5p could enhance cell apoptosis and suppress the migration and proliferation of CC cells. +genetics_knock down_promote 32141547 hsa-mir-130a Colonic Neoplasms RESULTS Compared with adjacent tissues, the expression of miR-130a was significantly increased in colon cancer tissues (p=0.0125); the expression of miR-130a in transfected miR-130a mimic group was higher than that in NC group, but the expression in transfected miR-130a inhibitor group was significantly lower than that in NC group; overexpression of miR-130a significantly increased cell viability, proliferation, migration, and invasion of colon cancer cells, while knockdown of miR-130a significantly inhibited colon cancer cell biological activity; target prediction, qRT-PCR, and Western blot assays showed that miR-130a participated in the development and progression of colon cancer by targeting inhibition of PTEN expression. +genetics_overexpression_suppress 32141546 hsa-mir-802 Colorectal Neoplasms Importantly, the overexpression of FOXE1 could reverse the regulatory effects of miRNA-802 on the cellular behaviors of CRC. +circRNA target 32141542 hsa-mir-1 Colorectal Neoplasms CircDDX17 inhibited 5-Fu resistance and CRC progression via sponging miR +circRNA target 32141540 hsa-mir-335 Carcinoma, Hepatocellular CONCLUSIONS: Circ_0009910-silenced suppressed the growth and metastasis of HCC cells through upregulating the inhibitory effect of miR +circulation_biomarker_prognosis_ns 32141536 hsa-mir-26b Ovarian Neoplasms Furthermore, combined monitoring of serum miR-26b and miR-21 has a certain value in the clinical diagnosis and treatment of ovarian cancer. +circulation_biomarker_prognosis_ns 32141536 hsa-mir-21 Ovarian Neoplasms Furthermore, combined monitoring of serum miR-26b and miR-21 has a certain value in the clinical diagnosis and treatment of ovarian cancer. +genetics_knock down_suppress 32141535 hsa-mir-1301 Ovarian Neoplasms MATERIALS AND METHODS: The ovarian cancer SKOV3 cell line and the human ovarian cancer cisplatin-resistant strain cell SKOV3/DDP were cultured in vitro and microRNA1301 expression was analyzed by Real time PCR. +lncRNA target 32141533 hsa-mir-199a Ovarian Neoplasms MiR-199a-3p-mimics, miR-199a-3p-inhibitor, miR-NC, si-NORAD, Sh-NORAD, and NC were transfected into HO-8910 and A2780 cells, the expression levels of lncRNA NORAD and miR-199a-3p in ovarian cancer tissues and cells were detected by qRT-PCR, and the expression levels of N-cadherin, E-cadherin, and vimentin in cells were detected by WB. +genetics_overexpression_suppress 32141531 hsa-mir-449a Osteosarcoma yl)-2,5-diphenyl tetrazolium bromide) assays and transwell assays indicated that miR-449a overexpression significantly repressed OS cell proliferation, invasion, and migration. +lncRNA target 32141527 hsa-mir-26b Diabetes, Gestational OBJECTIVE: The aim of this study was to explore the influence of micro ribonucleic acid (miR)-26b on gestational diabetes mellitus in rats via the phosphatidylinositol 3-hydroxy kinase/protein kinase B (PI3K/Akt) signaling pathway. CONCLUSIONS: MiR-26b accelerates the progression of gestational diabetes by inhibiting the PI3K/Akt signaling pathway. +lncRNA target 32141427 hsa-mir-149 Osteoarthritis induced inflammatory responses in OA via JAK2/STAT3 pathway. +lncRNA target 32141418 hsa-mir-509 Lung Neoplasms MiR3-5p- NONHSAT112228.2 regulatory axis can inhibit the proliferation and migration of lung cancer cells. +genetics_knock down_promote 32141339 hsa-mir-544 Spinal Cord Injuries overexpressing BMSCs improved functional recovery and promoted neuronal survival by attenuating inflammation after SCI. +lncRNA target 32141101 hsa-mir-4295 Osteosarcoma Overall, these results demonstrate that PTPN14 is a miR-4295 target gene and it exerts a tumour-suppressive function in osteosarcoma cells via inactivation of YAP1. +other 32140884 hsa-mir-15a Familial Mediterranean Fever 3p, and miR-365a-3p were up-regulated in FMF patients. +other 32140884 hsa-let-7a Familial Mediterranean Fever 3p, and miR-365a-3p were up-regulated in FMF patients. +other 32140884 hsa-mir-23a Familial Mediterranean Fever 3p, and miR-365a-3p were up-regulated in FMF patients. +other 32140884 hsa-mir-181b Familial Mediterranean Fever 3p, and miR-365a-3p were up-regulated in FMF patients. +other 32140884 hsa-mir-106b Familial Mediterranean Fever 3p, and miR-365a-3p were up-regulated in FMF patients. +other 32140884 hsa-mir-181c Familial Mediterranean Fever 3p, and miR-365a-3p were up-regulated in FMF patients. +other 32140884 hsa-let-7c Familial Mediterranean Fever 3p, and miR-365a-3p were up-regulated in FMF patients. +other 32140884 hsa-mir-15b Familial Mediterranean Fever 3p, and miR-365a-3p were up-regulated in FMF patients. +other 32140884 hsa-mir-24 Familial Mediterranean Fever 3p, and miR-365a-3p were up-regulated in FMF patients. +other 32140884 hsa-let-7g Familial Mediterranean Fever 3p, and miR-365a-3p were up-regulated in FMF patients. +other 32140884 hsa-mir-27a Familial Mediterranean Fever 3p, and miR-365a-3p were up-regulated in FMF patients. +other 32140884 hsa-mir-25 Familial Mediterranean Fever 3p, and miR-365a-3p were up-regulated in FMF patients. +other 32140884 hsa-mir-29b Familial Mediterranean Fever 3p, and miR-365a-3p were up-regulated in FMF patients. +other 32140884 hsa-mir-26b Familial Mediterranean Fever 3p, and miR-365a-3p were up-regulated in FMF patients. +other 32140884 hsa-mir-29c Familial Mediterranean Fever 3p, and miR-365a-3p were up-regulated in FMF patients. +other 32140884 hsa-mir-17 Familial Mediterranean Fever 3p, and miR-365a-3p were up-regulated in FMF patients. +other 32140884 hsa-mir-181a Familial Mediterranean Fever 3p, and miR-365a-3p were up-regulated in FMF patients. +other 32140884 hsa-mir-214 Familial Mediterranean Fever 3p, and miR-365a-3p were up-regulated in FMF patients. +lncRNA target 32140823 hsa-mir-216a Parkinson Disease miR-216a regulated the progression of PD by regulating Bax, and miR-216a may be a potential target for PD. +other 32140172 hsa-mir-26b Cardiomegaly 3p may help distinguish physiological and pathological LVH. +other 32140172 hsa-mir-497 Cardiomegaly 3p may help distinguish physiological and pathological LVH. +other 32140172 hsa-mir-204 Cardiomegaly 3p may help distinguish physiological and pathological LVH. +exosome 32140072 hsa-mir-26b Colonic Neoplasms In summary, we revealed the fact that a large number of passenger-strand miRNAs exist in exosomes of colon cancer cells, these miRNAs are preliminarily categorized into two sets, and miR3p and miR-26b-3p, as representatives of each set, showed opposite functions. +exosome 32140072 hsa-mir-2277 Colonic Neoplasms In summary, we revealed the fact that a large number of passenger-strand miRNAs exist in exosomes of colon cancer cells, these miRNAs are preliminarily categorized into two sets, and miR3p and miR-26b-3p, as representatives of each set, showed opposite functions. +transcription factor target 32140063 hsa-mir-148b Precursor Cell Lymphoblastic Leukemia-Lymphoma miR-148b directly targeted Bcl-w, decreased the cell viability and colony formation, while promoted apoptosis, in irradiated BCL cells. +lncRNA target 32139705 hsa-mir-144 Glioma The MTT and cell cycle assay indicated miR-144 suppressed glioma cells proliferation through modulating FGF mediated Akt signaling pathway. +lncRNA target 32139670 hsa-mir-657 Stomach Neoplasms With microRNA and circular RNA-sequencing analyses of GC xenograft models, we demonstrated that circRACGAP1 functioned as an endogenous sponge for miR-3657 to inhibit its activity and further upregulate ATG7 expression. +lncRNA target 32139664 hsa-mir-498 Esophageal Squamous Cell Carcinoma CONCLUSIONS Inhibition of TUG1 hampered cell proliferation and invasion by downregulating CDC42 via upregulating miR-498 in ESCC cells. +genetics_overexpression_promote 32139259 hsa-mir-199a Retinoblastoma METHODS: Paired RB samples were collected, and the expression levels of TMPO-AS1, miR-199a-5p and HIF-1alpha were examined by quantitative real-time polymerase chain reaction (qRT-PCR); TMPO-AS1 overexpressing plasmids and TMPO-AS1 shRNA were transfected into HXO-RB44 and SO-Rb50 cell lines respectively, and then proliferation, migration and invasion of RB cells were detected by CCK-8 assay and Transwell method. +epigenetics 32138771 hsa-mir-92b Nasopharyngeal Carcinoma Furthermore, our data suggested that SEPT9_v2 inhibits proliferation and migration of nasopharyngeal carcinoma cells through inactivation of the Wnt/beta-catenin signaling pathway via miR92b-3p/FZD10. CONCLUSIONS: This study delineates SEPT9_v2, frequently silenced by promoter hypermethylation, exerts anti-tumor functions through inactivation of the Wnt/beta-catenin signaling pathway via miR92b-3p/FZD10 in nasopharyngeal carcinoma cells and, hence, SEPT9_v2 may be a promising therapeutic target and biomarker for nasopharyngeal carcinoma. +lncRNA target 32138732 hsa-mir-145 Reperfusion Injury, Cerebral Ischemia CONCLUSION: Taken together, our study confirmed that MALAT1 promotes cerebral ischemia-reperfusion injury by affecting AQP4 expression through competitively binding miR-145, indicating that MALAT1 might be a new therapeutic target for treatment cerebral ischemic stroke. +genetics_overexpression_promote 32138716 hsa-mir-25 Carcinoma, Non-Small-Cell Lung In NSCLC cells, miR-25 overexpression led to downregulated RECK and attenuated the effects of MAGI2-AS3 overexpression, while MAGI2-AS3 and miR-25 failed to affect each other. CONCLUSION: Therefore, MAGI2-AS3 may sponge miR-25 to upregulate RECK, thereby inhibiting NSCLC cell invasion and migration. +genetics_overexpression_promote 32138690 hsa-mir-210 Liver Neoplasms RESULTS: MiRNA-210 was overexpressed in the liver tissues of HBV-associated cirrhosis and liver cancer, and in HepG2 and HepG2.2.15 cells (P < 0.05). +lncRNA target 32138544 hsa-mir-154 Carcinoma, Renal Cell LINC01939 and miR-154 in RCC tissues and cell lines were detected using qRT-PCR assay. Up-regulation of LINC01939 inhibited proliferation and migration of RCC cells by down-regulating miR-154. +other 32138537 hsa-mir-145 Myocardial Ischemia Following in vivo myocardial infarction (MI) study, the data revealed the myocardial infarct area reduced by 48.5%, 44.6%, and 48.5% in EGCG (50 mg/kg) or miR-145 dominant or Dab2 siRNA groups after myocardial infarction for 28 days, respectively. +lncRNA target 32138500 hsa-mir-18a Hemangioma Moreover, lncRNA CASC2 was confirmed to bind with miR-18a-5p, which could reverse lncRNA CASC2-induced anti-proliferative effects by targeting FBXL3 in HAs cells. Altogether, our findings demonstrated that lncRNA CASC2 suppressed the growth of HAs cells by regulating miR-18a-5p/FBXL3 axis. +circulation_biomarker_diagnosis_up 32138469 hsa-mir-146a Aortic Aneurysm, Abdominal Pearson's method analysis showed that miRNA-146a in the serum of AAA patients was negatively correlated with serum TNF-alpha, IFN-gamma and CRP, and was positively correlated with serum IL-10. +lncRNA target 32138369 hsa-mir-24 Ischemia 3p inhibition increases the production of dysfunctional microvessels, impairing perfusion. +lncRNA target 32138369 hsa-mir-24 Myocardial Infarction miR3p-3p directly represses eNOS, GATA2, and PAK4 in endothelial cells (ECs), thus inhibiting angiogenesis during development and in the infarcted heart. +other 32135645 hsa-mir-183 Stomach Neoplasms CHST1 and miR5p can be used as prognostic factors of gastric cancer. +lncRNA target 32135643 hsa-mir-17 Esophageal Squamous Cell Carcinoma 5p participates in the carcinogenesis and development of ESCC, thus may be a potential therapeutic target for ESCC patients. +other 32135463 hsa-mir-155 Colitis RESULTS: We found miR-155 antagomir can reach colon tissues in DSS-induced colitis and indeed ameliorated DSS-induced experimental colitis. CONCLUSION: Silencing of miR-155 attenuates DSS-induced colitis by regulating Th17/Treg cell balance and Jarid2/Wnt/beta-catenin participated in the process. +other 32135232 hsa-mir-3065 Alzheimer Disease 5p, and expression of P-S396-tau in EVs might provide a combinatorial protein and miRNA signature to differentiate between HC, patients with MCI or VaD from patient with sporadic AD. +other 32135232 hsa-mir-424 Alzheimer Disease 5p, and expression of P-S396-tau in EVs might provide a combinatorial protein and miRNA signature to differentiate between HC, patients with MCI or VaD from patient with sporadic AD. +other 32135232 hsa-mir-93 Alzheimer Disease 5p, and expression of P-S396-tau in EVs might provide a combinatorial protein and miRNA signature to differentiate between HC, patients with MCI or VaD from patient with sporadic AD. +lncRNA target 32135167 hsa-mir-1 Cardiotoxicity MiR5p acted as a negative regulator of circPan3 by directly suppressing QKI, which may be a potential therapeutic target and strategy for DOX-induced cardiotoxicity. +lncRNA target 32135165 hsa-mir-129 Poikiloderma with Neutropenia In conclusion, MALAT1 was enhanced after PNI and it promoted the proliferation and migration of Schwann cells through sponging miR5p to increase BDNF expression and secretion. +genetics_overexpression_promote 32135030 hsa-mir-130a Ovarian Neoplasms Moreover, the inhibitory effects of miR-130a-5p on the OC cell growth were reversed by FEZF1-AS1 overexpression, which was associated with the increase in SOX4 expression. In conclusion, our results revealed that FEZF1-AS1 promoted the metastasis and proliferation of OC cells by targeting miR-130a-5p and its downstream SOX4 expression. +other 32134323 hsa-mir-1275 Carcinoma, Hepatocellular Aim: The aim of this study was to investigate the association of miR-1275 rs16759, IGF2BP1 rs11079850 and IGF2BP3 rs34414305 with hepatocellular carcinoma (HCC) risk. +circulation_biomarker_diagnosis_up 32133664 hsa-mir-431 Stomach Neoplasms In addition, after down-regulated the circRNA_0005075 expression by plasmid transfection in GC cells, the Cell Counting Kit-8 (CCK-8), EDU, transwell assay were conducted to evaluate the function of circRNA_0005075 or miR-431 on cell proliferation, metastasis in vitro. +genetics_overexpression_promote 32133348 hsa-mir-199a Carcinoma, Hepatocellular Overexpressing LINC00460 and silencing miR-199a-3p promoted cell invasion, inhibited apoptosis of HCC, and arrested the cell cycle in S phase while opposite results were obtained when silencing LINC00346, CDK1, and CCNB1. +lncRNA target 32133007 hsa-let-7f Lupus Erythematosus, Systemic To explore the role of let-7f in the disease pathogenesis, we showed that expression levels of let-7f in SLE BM-MSCs were negatively associated with SLE disease activity, and the predicted let-7 family targeted gene expression of interlukin-6 (IL-6) was significantly higher in BM-MSCs from SLE patients compared to normal controls (NOR). +lncRNA target 32132611 hsa-mir-494 Breast Neoplasms In conclusion, TFPI-2 mRNA levels were upregulated by miR-494 in MCF-7 breast cancer cells most likely by an indirect association where miR-494 targeted the transcription factors AHR and ELF-1. +other 32132553 hsa-mir-21 Colorectal Neoplasms We observed that baseline miRNA-21 and 92a outperformed carcinoembryonic antigen levels in the diagnosis of our 44 mCRC patients, compared to 17 healthy volunteers. +other 32132553 hsa-mir-92a Colorectal Neoplasms We observed that baseline miRNA-21 and 92a outperformed carcinoembryonic antigen levels in the diagnosis of our 44 mCRC patients, compared to 17 healthy volunteers. +genetics_knock down_promote 32132320 hsa-mir-665 Myocardial Infarction Therefore, knockdown of miR-665 protects against cardiomyocyte ischemia/reperfusion injury-induced ROS accumulation and apoptosis through activating Pak1/Akt signaling in MI. +other 32132049 hsa-mir-146a Colorectal Neoplasms Furthermore, miR-146a rs2910164 was associated with reduced risk of gastric cancer in the dominant model (pooled odds ratio=0.91, 95% confidence intervaI=0.83-0.99), increased risk of colorectal cancer under the recessive model and reduced risk of colorectal cancer under the over-dominant model in the European population. +lncRNA target 32132039 hsa-mir-187 Uterine Cervical Neoplasms In this study, we explored the function of miR-187* in cervical cancer cells. CONCLUSION: miR-187* seems to enhance SiHa cervical cancer cell oncogenicity via suppression of the WWOX pathway. +circulation_biomarker_diagnosis_up 32131978 hsa-mir-92a Barrett Esophagus As observed in serum samples, miR-92a-3p was over-expressed in HG-IEN/BAc samples in comparison to naive esophageal squamous mucosa and BE and was mainly localized within the epithelial cells, supporting neoplastic cells as the main source of the circulating miRNA. +circulation_biomarker_prognosis_down 32131777 hsa-mir-26b Nasopharyngeal Neoplasms After these down-regulated miRNAs were dealed with bioinformatics analysis and normalization, only 5 different miRNAs were significantly reduced, which there were no significant difference in the expression of miRNA-26b, miRNA-29a and miRNA-125b before CCRT, and the expression of miRNA-143 and miRNA-29b after CCRT in the serum samples of 48 NPC patients. CONCLUSIONS: For loco-regionally advanced NPC patients treated with CCRT, especially high-risk patients- serum miRNAs, such as miRNA-29a, miRNA-125b and miRNA-26b etc., play an important role in predicting prognosis factors of PFS and OS, which will contribute to the strategic direction for future research. +circulation_biomarker_prognosis_down 32131777 hsa-mir-29a Nasopharyngeal Neoplasms After these down-regulated miRNAs were dealed with bioinformatics analysis and normalization, only 5 different miRNAs were significantly reduced, which there were no significant difference in the expression of miRNA-26b, miRNA-29a and miRNA-125b before CCRT, and the expression of miRNA-143 and miRNA-29b after CCRT in the serum samples of 48 NPC patients. CONCLUSIONS: For loco-regionally advanced NPC patients treated with CCRT, especially high-risk patients- serum miRNAs, such as miRNA-29a, miRNA-125b and miRNA-26b etc., play an important role in predicting prognosis factors of PFS and OS, which will contribute to the strategic direction for future research. +circulation_biomarker_prognosis_down 32131777 hsa-mir-125b Nasopharyngeal Neoplasms After these down-regulated miRNAs were dealed with bioinformatics analysis and normalization, only 5 different miRNAs were significantly reduced, which there were no significant difference in the expression of miRNA-26b, miRNA-29a and miRNA-125b before CCRT, and the expression of miRNA-143 and miRNA-29b after CCRT in the serum samples of 48 NPC patients. CONCLUSIONS: For loco-regionally advanced NPC patients treated with CCRT, especially high-risk patients- serum miRNAs, such as miRNA-29a, miRNA-125b and miRNA-26b etc., play an important role in predicting prognosis factors of PFS and OS, which will contribute to the strategic direction for future research. +lncRNA target 32131767 hsa-mir-1179 Nasopharyngeal Carcinoma Moreover, HMGB3, a target of miR-1179, regulated NPC progression by mediating LncRNA-SNHG5/miR-1179 axis. +other 32131693 hsa-mir-15a Brain Infarction Deletion of miR-15a/16-1 cluster in endothelium attenuates post-stroke brain infarction and atrophy and improves the long-term sensorimotor and cognitive recovery against ischemic stroke. +other 32131693 hsa-mir-15a Brain Ischemia OBJECTIVE: To investigate the functional significance and molecular mechanism of endothelial miR-15a/16-1 cluster on angiogenesis in the ischemic brain. +other 32131693 hsa-mir-15a Ischemic Stroke Deletion of miR-15a/16-1 cluster in endothelium attenuates post-stroke brain infarction and atrophy and improves the long-term sensorimotor and cognitive recovery against ischemic stroke. Endothelial cell-selective deletion of the miR-15a/16-1 cluster up-regulated the protein expression of pro-angiogenic factors VEGFA (vascular endothelial growth factor), FGF2 (fibroblast growth factor 2), and their receptors VEGFR2 (vascular endothelial growth factor receptor 2) and FGFR1 (fibroblast growth factor receptor 1) after ischemic stroke. +circulation_biomarker_diagnosis_up 32131693 hsa-mir-15a Stroke Endothelium-targeted deletion of the miR-15a/16-1 cluster also enhances post-stroke angiogenesis by promoting vascular remodeling and stimulating the generation of newly formed functional vessels, and increases the ipsilateral cerebral blood flow. +other 32131653 hsa-mir-214 Cardiomyopathies Previously, we demonstrated that miR-214 had a protective effect against myocardial apoptosis and myocardial fibrosis. +lncRNA target 32131507 hsa-mir-221 Prostatic Neoplasms 3p was explained with a specific targeting of VEGFR2, we examined whether miR +other 32131485 hsa-mir-592 Uveal melanoma Moreover, hsa-miR-592 also showed correlation with monosomy 3 tumors. +other 32130980 hsa-mir-375 Osteosarcoma Altogether, we confirmed the up-regulated circ-0060428 could improve the proliferation and survival of osteosarcoma cells by sponging miR-375 to upregulate RBPJ expression. +lncRNA target 32130794 hsa-mir-340 Small Cell Lung Carcinoma CONCLUSION: We demonstrated that downregulated expression of hsa-miR5p may affect cisplatin resistance by mediating SOX2 expression in SCLC cells, which may provide a potential target for the therapy of chemoresistant SCLCs. +genetics_overexpression_promote 32130788 hsa-mir-143 Squamous Cell Carcinoma of Head and Neck 3p, and MYO6 overexpression reversed the effects of miR +genetics_knock down_promote 32130678 hsa-mir-1256 Thyroid Cancer, Papillary Furthermore, the suppressive effects of miR-1256 on the expression of PCNA, CDK4, Cyclin D1, and p21 were partially reversed by HTR3A overexpression in PTC cells. +lncRNA target 32130660 hsa-mir-193a Esophageal Squamous Cell Carcinoma CONCLUSIONS: We found that silencing of LINC01234 suppresses EC development by inhibiting CCNE1 through competitively binding to miR-193a-5p, which suggests that LINC01234 may represent a novel target for EC therapy. +lncRNA target 32130618 hsa-mir-133a Atrial Fibrillation In conclusion, our study demonstrated the role of MIAT downregulation in alleviating AF and AF-induced myocardial fibrosis, and the functional regulatory pathway of MIAT targeting miR-133a-3p. +genetics_overexpression_suppress 32130290 hsa-mir-106b Atherosclerosis This research aimed to explore the molecular mechanism of microRNA (miR)-106b in cell apoptosis of atherosclerosis (AS). Overexpression of miR-106b in ox-LDL-induced AS inhibited endothelial cell apoptosis. +genetics_overexpression_promote 32129525 hsa-mir-200c Wilms Tumor Mechanically, nuclear factor-kappaB (NF-kappaB) pathway was confirmed to be associated with Wilms' tumor progression; miR-200b/c/429 overexpression inactivated NF-kappaB pathway as miR-200b/c/429 was identified to target IkappaB kinase beta (IKK-beta), an NF-kappaB pathway-related gene. +genetics_overexpression_promote 32129525 hsa-mir-200b Wilms Tumor Mechanically, nuclear factor-kappaB (NF-kappaB) pathway was confirmed to be associated with Wilms' tumor progression; miR-200b/c/429 overexpression inactivated NF-kappaB pathway as miR-200b/c/429 was identified to target IkappaB kinase beta (IKK-beta), an NF-kappaB pathway-related gene. +genetics_overexpression_promote 32129525 hsa-mir-429 Wilms Tumor Mechanically, nuclear factor-kappaB (NF-kappaB) pathway was confirmed to be associated with Wilms' tumor progression; miR-200b/c/429 overexpression inactivated NF-kappaB pathway as miR-200b/c/429 was identified to target IkappaB kinase beta (IKK-beta), an NF-kappaB pathway-related gene. +other 32129458 hsa-mir-128 Pulmonary Disease, Chronic Obstructive Thus, we concluded that MIR155HG contributed to the apoptosis and inflammation of HPMECs in smoke-related COPD by regulating miR5p/BRD4 axis, providing a novel insight on the pathogenesis of COPD and a therapeutic strategy on COPD treatments. +genetics_overexpression_suppress 32129446 hsa-mir-326 Precursor Cell Lymphoblastic Leukemia-Lymphoma Statistical analysis showed a significant downregulation of miR-326 and overexpression of BALLC in drug-resistant acute lymphoblastic leukemia cell line and patients compared with the parental cell line and drug-sensitive patients, respectively (P = 0.015, 0.005, 0.0484 and 0.0005, respectively). +circulation_biomarker_diagnosis_up 32129362 hsa-mir-34b Diabetes Mellitus Nitrate administration in the DN group also decreased miR-34b (p < 0.001) and p53 mRNA (p < 0.001) expression, and increased serum insulin and NOx levels compared to the untreated diabetic rats. +genetics_knock down_promote 32129151 hsa-mir-384 Osteosarcoma To probe whether miR-384 played a tumor suppression role in osteosarcoma, we carried out gain-of-function and loss-of-function assays. +genetics_overexpression_promote 32128987 hsa-mir-451a Prostatic Neoplasms Overexpression of miR-451a inhibits PCa cell proliferation, colony formation, cell invasion and promotes cell apoptosis, while the overexpression of PSMB8 caused the opposite effects. +lncRNA target 32128852 hsa-mir-20 Carcinoma, Hepatocellular In conclusion, LINC00174 is a sponge of tumour suppressor miR-320, enhances the expression of S100A10 indirectly and functions as an oncogenic lncRNA in HCC. +lncRNA target 32128112 hsa-mir-0308 Carcinoma, Hepatocellular 3p upregulation dramatically suppressed HCC cell proliferation and induced G1/S cell cycle arrest by directly targeting CDK6/Cyclin D1. +transcription factor target 32128074 hsa-mir-146a Allergic Inflammation In conclusion, we demonstrated that MSC-sEV were able to prevent ILC2-dominant allergic airway inflammation at least partially through miR-146a-5p, suggesting that MSC-sEV could be a novel cell-free strategy for the treatment of allergic diseases. +circRNA target 32127962 hsa-mir-335 Nasopharyngeal Carcinoma "Finally, it was demonstrated by reverse transcription-quantitative polymerase chain reaction assay and wound healing assay that curcumin could enhance radiosensitization of NPC cell lines via mediating regulation of tumor stem-like cells by the ""hsa_circRNA_102115""-""hsa-miR3p""-""MAPK1"" interaction network." +genetics_knock down_promote 32127947 hsa-mir-128 Uterine Cervical Neoplasms The next study indicated that lnc-SNHG16 knockdown markedly increased miR-128 level which is down-regulated in CC. +genetics_GWAS 32127940 hsa-mir-27a Uterine Cervical Neoplasms The pre-miR-137 rs1625579 T > G and pre-miR-27a rs895819 T > C polymorphisms may provide protective effects against susceptibility to cervical cancer risk. +genetics_GWAS 32127940 hsa-mir-137 Uterine Cervical Neoplasms Moreover, the pre-miR-137 rs1625579 T > G polymorphism showed protective effects in premenopausal women, squamous cell carcinoma patients, and patients with unclassified types of pathologies; the pre-miR-27a rs895819 T > C polymorphism was also associated with a decreased risk in patients older than 49 years, menopausal women, and women who had experienced vaginal pregnancies. +other 32127902 hsa-mir-34a Burkitt Lymphoma In MYC+ tumours, the relative expression were: hsa-miR-127(2.09);hsa-miR-34a (2.8) and MYC- hsa-miR-127 (1.2), hsa-miR-34a (1.0). +other 32127902 hsa-mir-127 Burkitt Lymphoma In MYC+ tumours, the relative expression were: hsa-miR-127(2.09);hsa-miR-34a (2.8) and MYC- hsa-miR-127 (1.2), hsa-miR-34a (1.0). +lncRNA target 32127798 hsa-mir-29c Sarcoma The ceRNA network, especially the subnetwork LncRNA (KCNQ1OT1)-miRNA (has-miR-29c-3p)-mRNA (JARID2, CDK8, DNMT3A, TET1) was a promising therapeutic target for the STS sub-cluster associated with a poor prognosis. +other 32127787 hsa-mir-142 Parkinson Disease However, the impact and underlying regulatory mechanism of miR5p in Parkinson's disease (PD) are still ominous. +lncRNA target 32127787 hsa-mir-142 late onset Parkinson's disease 5p functions as a neuroprotective regulator in 6-OHDA-induced neuronal SH-SY5Y cells simulating PD model in vitro via regulating autophagy-related protein BECN1 and autophagy to influence cell viability. +other 32127787 hsa-mir-142 Nervous System Diseases BACKGROUND: MiR5p has been demonstrated to hold significant implications in neurological diseases. +other 32127645 hsa-mir-372 Urinary Bladder Neoplasms Our findings thus establish a critical role for the CUL4B-miR-372/373-PIK3CA/AKT axis in the pathogenesis of BC and have important prognostic and therapeutic implications in BC. +other 32127645 hsa-mir-373 Urinary Bladder Neoplasms Our findings thus establish a critical role for the CUL4B-miR-372/373-PIK3CA/AKT axis in the pathogenesis of BC and have important prognostic and therapeutic implications in BC. +lncRNA target 32127518 hsa-mir-124 Glioma 3p-RELA axis, which may serve as a prognostic indicator and potential therapeutic target for glioma treatment. +lncRNA target 32127416 hsa-mir-204 Autistic Disorder We further confirmed that some ASD risk genes (NLGN1, STAG1, HSD11B1, VIP, and UBA6) were regulated by an up-regulated circRNA (circARID1A) via sponging a down-regulated microRNA (miR3p) in human neuronal cells. +transcription factor target 32127169 hsa-mir-486 Polycystic Ovary Syndrome 5p may be implicated in follicular development in PCOS by targeting PRELID2. +genetics_knock down_suppress 32127028 hsa-mir-140 Retinoblastoma In addition, XIST overexpression or miR +circulation_biomarker_diagnosis_ns 32127011 hsa-mir-32 Myocardial Infarction, Acute CONCLUSION: The data of this study revealed that the increased serum miR +lncRNA target 32127004 hsa-mir-22 Colorectal Neoplasms CONCLUSION: MIR22HG acts as a tumor suppressor in CRC. +tissue_expression_up 32126572 hsa-mir-155 Toxoplasmosis CSF-derived EVs from CT/HIV patients) up-expressed miR +circulation_biomarker_diagnosis_up 32126572 hsa-mir-146a Toxoplasmosis Serum-derived EVs from group II (cerebral and gestational toxoplasmosis) up-expressed miR-125b-5p and miR-146a-5p. +circulation_biomarker_diagnosis_up 32126572 hsa-mir-125b Toxoplasmosis Serum-derived EVs from group II (cerebral and gestational toxoplasmosis) up-expressed miR-125b-5p and miR-146a-5p. +tissue_expression_up 32126572 hsa-mir-21 Toxoplasmosis CSF-derived EVs from CT/HIV patients) up-expressed miR +tissue_expression_up 32126572 hsa-mir-29c Toxoplasmosis CSF-derived EVs from CT/HIV patients) up-expressed miR +transcription factor target 32126510 hsa-mir-98 Glomerulonephritis, IGA 5p might target chemokine ligand 3 (CCL3). +transcription factor target 32126314 hsa-mir-99a Bone Diseases Ultimately, it supports miR-99a-5p as a target candidate for future miRNA-based therapies for bone diseases associated with bone remodeling deregulation. +lncRNA target 32126145 hsa-mir-34c Neuralgia This study aimed to test the hypothesis that miR-34c-5p can modulate neuropathic pain in rat models with chronic constriction injury (CCI) of sciatic nerve, via interaction with the SIRT1/STAT3 signaling pathway SIRT1 was validated as a target gene of miR-34c-5p and could be negatively regulated by miR-34c-5p. +genetics_overexpression_promote 32125767 hsa-mir-4744 Glioma Overexpression of RIOK2 could reverse the effects of miR-4744 up-regulation on the migration, invasion and EMT process in glioma cells. +genetics_overexpression_suppress 32125733 hsa-mir-320d Carcinoma, Hepatocellular Finally, overexpression of miR-320d inhibited the proliferation and invasion of HCC cells, and BMI1 was demonstrated to be a direct target of miR-320d. +lncRNA target 32125723 hsa-mir-124 Triple Negative Breast Neoplasms 3p.1 promotes TNBC cell growth by controlling Axin1, suggesting that targeting miR +transcription factor target 32125507 hsa-mir-29a Myopia CONCLUSIONS: Genipin inhibits the scleral expression of the miR-29 cluster and MMP2 and promotes COL1A1 expression in a guinea pig model of myopia. +tissue_expression_up 32125337 hsa-mir-16 Vitamin B Deficiency In conclusion, we demonstrated that Se deficiency regulates the miR +transcription factor target 32125337 hsa-mir-16 Tracheal Diseases By establishing models of tracheal injury in Se-deficient chickens, we verified the targeting relationship between chicken-derived miR5p and PI3K through bioinformatics, qRT-PCR and WB analyses, and we measured the changes in the expression of genes related to the PI3K/AKT pathway, RIP3/MLKL pathway and MAPK pathway and of heat shock proteins. +genetics_GWAS 32125286 hsa-mir-146a Immune System Diseases Furthermore, we identified the MIR146A SNP rs2910164 as a biomarker to predict severe irAE development in ICI-treated patients. +other 32125187 hsa-mir-383 Diabetic Retinopathy QPCR analysis showed that lncRNA LUADT1 was downregulated, and miR-383 was upregulated in DR. Therefore, LUADT1 regulates PRX3 by serving as the endogenous sponge of miR-383 in DR to regulate cell apoptosis. +lncRNA target 32125086 hsa-mir-373 Cholangiocarcinoma miR-373 targeted ULK1 to initiate inhibition of autophagy and subsequent promotion of apoptosis in cholangiocarcinoma cells. +lncRNA target 32125046 hsa-mir-182 Cardiomegaly In brief, our study illustrated that silenced SNHG16 repressed Ang II-imposed cardiac hypertrophy via targeting miR5p/IGF1 axis. +lncRNA target 32124962 hsa-let-7 Breast Neoplasms Moreover, the H19/let7/Lin28 network was found to contribute to autophagy by inhibiting EMT in BC cells. +circulation_biomarker_diagnosis_ns 32124924 hsa-mir-217 Heart Failure We found that circulating miR +circulation_biomarker_diagnosis_ns 32124924 hsa-mir-155 Heart Failure We found that circulating miR +circulation_biomarker_diagnosis_ns 32124924 hsa-mir-216a Heart Failure We found that circulating miR +circulation_biomarker_diagnosis_ns 32124924 hsa-mir-21 Heart Failure We found that circulating miR +other 32124921 hsa-mir-107 Alzheimer Disease CONCLUSION: SOX21-AS1 silencing could attenuate Abeta1induced neuronal damage by sponging miR-107, which provided a possible strategy for the treatment of AD. +lncRNA target 32124921 hsa-mir-107 Distal arthrogryposis type 2B treated SH-SY5Y and SK-N-SH cells mediated by miR-107 inhibition were partly recovered by SOX21-AS1 depletion. +circulation_biomarker_diagnosis_ns 32124804 hsa-mir-4714 Gallbladder Diseases 3p in the blood serum in children with functional disorders of the gallbladder and Oddi's sphincter significantly decreased (1.93+/-0.58 SU and 1,14+/-0,53 SU respectively) (p<0.05). +genetics_GWAS 32124721 hsa-mir-146a Malaria Micro-RNAs (miRNAs) play a crucial role in immune regulation, and a common miRNA-146a polymorphism (rs2910164) increased the odds of falciparum malaria in pregnant African women. +other 32124583 hsa-mir-454 Ovarian Neoplasms CONCLUSION: CCAT1/miR-454/survivin axis conferred cisplatin resistance in ovarian cancer cells. +circulation_biomarker_diagnosis_down 32124558 hsa-mir-130a Breast Neoplasms 3p were downexpressed in BC tissues as well as plasma. +circulation_biomarker_diagnosis_down 32124558 hsa-mir-152 Breast Neoplasms 3p were downexpressed in BC tissues as well as plasma. +circulation_biomarker_diagnosis_down 32124558 hsa-mir-144 Breast Neoplasms 3p were downexpressed in BC tissues as well as plasma. +genetics_overexpression_promote 32124270 hsa-mir-1297 Glioblastoma Furthermore, overexpression of KPNA2 could reverse miR-1297 mimic induced cell growth arrest and inhibition of glycolysis in GBM cells. +other 32124227 hsa-mir-224 Hepatitis, Autoimmune Furthermore, miR-224 level correlated with steatosis and miR-155 expression with fibrosis stage in CHC. Nevertheless, miR-224 and - 155 seem to be associated with CHC progression. +other 32124227 hsa-mir-224 Hepatitis C Furthermore, miR-224 level correlated with steatosis and miR-155 expression with fibrosis stage in CHC. Nevertheless, miR-224 and - 155 seem to be associated with CHC progression. +other 32124227 hsa-mir-155 Hepatitis, Autoimmune The level of miR-101 was increased in case of CHC as compared with AIH, however, miR-155, -204 and 224 resulted in no expressional. +other 32124227 hsa-mir-155 Hepatitis C The level of miR-101 was increased in case of CHC as compared with AIH, however, miR-155, -204 and 224 resulted in no expressional. +other 32124227 hsa-mir-101 Hepatitis C In the present study, we aimed to examine and compare autophagy activity in chronic hepatitis C (CHC) and autoimmune hepatitis (AIH) by detecting the expression of autophagy (LC3 and p62) and mitochondrium-related (TOMM20) proteins, as well as the levels of selected microRNAs (miR-101, -155, -204 and - 224) known to be involved in the regulation of autophagy. +other 32124227 hsa-mir-101 Hepatitis, Autoimmune In the present study, we aimed to examine and compare autophagy activity in chronic hepatitis C (CHC) and autoimmune hepatitis (AIH) by detecting the expression of autophagy (LC3 and p62) and mitochondrium-related (TOMM20) proteins, as well as the levels of selected microRNAs (miR-101, -155, -204 and - 224) known to be involved in the regulation of autophagy. +other 32124161 hsa-mir-1202 Neurogenic Inflammation However, the correlation between miR-1202 and neuroinflammation has not been reported. +circulation_biomarker_diagnosis_ns 32124161 hsa-mir-1202 high grade glioma Recent studies have shown that the level of miR-1202 in peripheral blood is closely related to brain activity and cognitive function in patients with depression, and it is involved in glioma pathological progress. +lncRNA target 32124161 hsa-mir-1202 Histiocytic Sarcoma MiR-1202 exerts neuroprotective effect by negatively regulating its target protein Rab1a, which can inactivate TLR4/NF-kappaB-involved inflammatory signaling pathway in OGD/R induced HM cells. +circulation_biomarker_diagnosis_ns 32124161 hsa-mir-1202 Neurotic Disorders Recent studies have shown that the level of miR-1202 in peripheral blood is closely related to brain activity and cognitive function in patients with depression, and it is involved in glioma pathological progress. +other 32124090 hsa-mir-21 Esophageal Squamous Cell Carcinoma In ESCC cells, IUR over-expression led to the increased expression levels of PTEN; while miR-21 over-expression led to decreased expression levels of PTEN. CONCLUSION: Therefore, IUR may up-regulate PTEN by sponging miR-21 to regulate cancer cell proliferation and apoptosis in ESCC. +circulation_biomarker_diagnosis_ns 32124045 hsa-mir-146a Mastitis, Bovine miR146a has been described as one of the main microRNA involved in the immune response of bovine mastitis, being expressed in tissue, blood and milk samples. +circulation_biomarker_prognosis_ns 32123723 hsa-mir-29a Breast Neoplasms In two case-control studies, qRT-PCR was used to analyze the peripheral blood serum of 15 CLL patients and tissue samples of 15 BC patients for the expression of miR-27b, miR-29a, and miR-155. +circulation_biomarker_prognosis_ns 32123723 hsa-mir-27b Breast Neoplasms In two case-control studies, qRT-PCR was used to analyze the peripheral blood serum of 15 CLL patients and tissue samples of 15 BC patients for the expression of miR-27b, miR-29a, and miR-155. +circulation_biomarker_prognosis_ns 32123723 hsa-mir-27b Leukemia, Lymphocytic, Chronic, B-Cell In two case-control studies, qRT-PCR was used to analyze the peripheral blood serum of 15 CLL patients and tissue samples of 15 BC patients for the expression of miR-27b, miR-29a, and miR-155. +circulation_biomarker_prognosis_ns 32123723 hsa-mir-155 Breast Neoplasms In two case-control studies, qRT-PCR was used to analyze the peripheral blood serum of 15 CLL patients and tissue samples of 15 BC patients for the expression of miR-27b, miR-29a, and miR-155. +circulation_biomarker_prognosis_ns 32123723 hsa-mir-29a Leukemia, Lymphocytic, Chronic, B-Cell In two case-control studies, qRT-PCR was used to analyze the peripheral blood serum of 15 CLL patients and tissue samples of 15 BC patients for the expression of miR-27b, miR-29a, and miR-155. +circulation_biomarker_prognosis_ns 32123723 hsa-mir-155 Leukemia, Lymphocytic, Chronic, B-Cell In two case-control studies, qRT-PCR was used to analyze the peripheral blood serum of 15 CLL patients and tissue samples of 15 BC patients for the expression of miR-27b, miR-29a, and miR-155. +lncRNA target 32123722 hsa-mir-143 Colorectal Neoplasms Our results suggested that Ad-RGD-Survivin-ZD55-miR-143 produced a strong antitumor effect by targeting KRAS and that this strategy could broaden the therapeutic options for treating colorectal cancer. +other 32123560 hsa-mir-141 Myocardial Reperfusion Injury These studies suggest that miR3p and CHD8 mediated cardiomyocyte apoptosis may offer a novel therapeutic strategy against myocardial I/R injury-induced cardiovascular diseases. +other 32123560 hsa-mir-141 Cardiovascular Diseases These studies suggest that miR3p and CHD8 mediated cardiomyocyte apoptosis may offer a novel therapeutic strategy against myocardial I/R injury-induced cardiovascular diseases. +lncRNA target 32123520 hsa-mir-4316 Stomach Neoplasms And western blot results indicated that miR-4316 significantly inhibited GC through repressing VEGF-A and c-Met. +other 32123492 hsa-mir-34a Colonic Neoplasms Next, we assessed expression of miR-140 and miR-34a in DOX-treated HCT116 and MDA-MB-231 cells. +transcription factor target 32123492 hsa-mir-140 Colonic Neoplasms Finally, we investigated whether miR-140 targets the 3' UTR of the gene encoding PD-L1 in HCT116 cells using the p2FP-RNAi RNAi reporter vector system. +lncRNA target 32123163 hsa-mir-222 Diabetic Cardiomyopathies Taken together, our data indicate that HMGA1 aggravates diabetic cardiomyopathy by directly regulating miR-222 promoter activity, which inhibits P27/mTOR-induced autophagy. +other 32123162 hsa-mir-612 Stomach Neoplasms Thus, our findings support a new regulatory axis between TRPM2-AS, miR-612, IGF2BP1, or FOXM1 which serve as crucial effectors in GC tumorigenesis and malignant development, suggesting a promising therapeutic and diagnostic direction for GC. +genetics_knock down_promote 32123074 hsa-mir-1 Esophageal Neoplasms Transcriptomics, genome sequencing, and metabolomics analyses in these Zn-deficient rats revealed the molecular basis of ESCC abrogation by miR-31 knockout. +circulation_biomarker_diagnosis_ns 32122654 hsa-mir-125a Pre-Eclampsia Quantitative real-time polymerase chain reaction (QRT-PCR) was performed to assess the expression of miR-125a-5p in normal and PE placental tissues and peripheral blood derived exosomes in the third trimester. +genetics_overexpression_promote 32122614 hsa-mir-155 Reticuloendotheliosis Virus Infections inhibitor, we found overexpression of miR-155 targeted caspase-6 and FOXO3a to inhibit apoptosis and accelerate cell cycle, thus improving viability of REV-infected CEFs. +lncRNA target 32122382 hsa-mir-210 Coronary Disease Additionally, the hub ceRNA network in EAT development involving MIR210HG, hsa-miR-449c-5p, and CACNA2D4 was generated and shown to target monocyte infiltration. In addition, the network includes monocytes, MIR210HG, and CACNA2D4, which were shown to target the RIG-I-like receptor signaling pathway and PPAR signaling pathway, indicating that these factors may be novel regulators and therapeutic targets in EAT development. +other 32122370 hsa-mir-1 Carcinoma, Non-Small-Cell Lung Then, the relative expression levels of miR-21, miR-210, miR-125b, miR-155, miR-375, and miR-31 by using this system were significantly correlated with NSCLC (P < 0.05). +other 32122370 hsa-mir-155 Carcinoma, Non-Small-Cell Lung Then, the relative expression levels of miR-21, miR-210, miR-125b, miR-155, miR-375, and miR-31 by using this system were significantly correlated with NSCLC (P < 0.05). +other 32122370 hsa-mir-375 Carcinoma, Non-Small-Cell Lung Then, the relative expression levels of miR-21, miR-210, miR-125b, miR-155, miR-375, and miR-31 by using this system were significantly correlated with NSCLC (P < 0.05). +other 32122370 hsa-mir-125b Carcinoma, Non-Small-Cell Lung Then, the relative expression levels of miR-21, miR-210, miR-125b, miR-155, miR-375, and miR-31 by using this system were significantly correlated with NSCLC (P < 0.05). +other 32122370 hsa-mir-210 Carcinoma, Non-Small-Cell Lung Then, the relative expression levels of miR-21, miR-210, miR-125b, miR-155, miR-375, and miR-31 by using this system were significantly correlated with NSCLC (P < 0.05). +other 32122370 hsa-mir-21 Carcinoma, Non-Small-Cell Lung Then, the relative expression levels of miR-21, miR-210, miR-125b, miR-155, miR-375, and miR-31 by using this system were significantly correlated with NSCLC (P < 0.05). +lncRNA target 32122144 hsa-mir-429 Osteosarcoma In conclusion, targeting the KLF8-miR +genetics_knock down_suppress 32122143 hsa-mir-377 Carcinoma, Hepatocellular 3p attenuated the effect of SNHG1 knockdown on proliferation, apoptosis, migration, invasion, and EMT of HCC cells. +lncRNA target 32122140 hsa-mir-103a Squamous Cell Carcinoma of Head and Neck In summary, miR-103a-3p inhibition represses proliferation and induces apoptosis of OSCC cells through regulating RCAN1, and miR-103a-3p may act as a novel diagnostic marker and therapeutic target for OSCC. +other 32121653 hsa-mir-223 Spinal Cord Injuries Taken together, we conclude that up-regulation of miR-21 and -223 might be closely associated with progression and the early course of TSCI, respectively. +other 32121653 hsa-mir-21 Spinal Cord Injuries Taken together, we conclude that up-regulation of miR-21 and -223 might be closely associated with progression and the early course of TSCI, respectively. +circulation_biomarker_diagnosis_up 32121086 hsa-let-7 Thyroid Cancer, Papillary Thus, the analysis of circulating let-7 can be a useful tool and support the currently used methods for PTC diagnosis. +circulation_biomarker_diagnosis_up 32121086 hsa-let-7d Thyroid Cancer, Papillary Thus, the analysis of circulating let-7 can be a useful tool and support the currently used methods for PTC diagnosis. +other 32120903 hsa-mir-202 Encephalitis, Tick-Borne Here, our results showed that miR5p was induced by red spotted grouper nervous necrosis virus (RGNNV) infection in zebrafish. +lncRNA target 32120345 hsa-mir-378a Atherosclerosis Therefore, the decreased expression of PGC-1alpha might account for suppression of miR-378a in VSMCs in AS. CONCLUSIONS: These findings highlight the protective role of the PGC-1alpha/NRF1/miR-378a regulatory axis in AS progression and suggest miR-378a as potential therapeutic target for AS treatment. +lncRNA target 32120026 hsa-mir-342 Carcinoma, Pancreatic Ductal 3p are potential leads for the development of targeted therapy for PDAC. +exosome 32120025 hsa-mir-9 Squamous Cell Carcinoma of Head and Neck enriched exosomes from HPV HNSCC can polarize macrophages into M1 phenotype and increase the radiosensitivity of HPV HNSCC. +genetics_knock down_promote 32120024 hsa-mir-497 Carcinoma, Pancreatic Ductal Furthermore, HOTTIP is regulated by miR-497 in PDAC cells, but HOTTIP is negatively correlated with miR-497 levels in PDAC tissues. In conclusion, HOTTIP is upregulated in PDAC due to the loss of the inhibitory miR-497; HOTTIP promotes PDAC progression through the canonical HOTTIP-HOXA13 axis. +lncRNA target 32119960 hsa-mir-135b Stomach Neoplasms CONCLUSIONS: Over-expressed lncRNA PCAT18 inhibits proliferation, migration and invasion of gastric cancer cells through regulation of miR-135b/CLDN11. +circRNA target 32119786 hsa-mir-37 Uterine Cervical Neoplasms 3p and TCF12, and could be potentially used as a diagnostic biomarker and therapy target. +other 32119650 hsa-mir-3 Alzheimer Disease The present study assessed whether miR-33 is involved in AD pathology. +genetics_knock down_promote 32119650 hsa-mir-3 Dehydration miR-33 knockdown suppressed inflammation, oxidative stress, and cell apoptosis. CONCLUSIONS Taken together, these findings suggest that miR-33 knockdown protects against Ass(2)(5)(-)(3)(5)-induced inflammation, oxidative stress, apoptosis, and synaptic damage by suppressing activation of the Akt/mTOR pathway. +genetics_knock down_promote 32119650 hsa-mir-3 Inflammation miR-33 knockdown suppressed inflammation, oxidative stress, and cell apoptosis. CONCLUSIONS Taken together, these findings suggest that miR-33 knockdown protects against Ass(2)(5)(-)(3)(5)-induced inflammation, oxidative stress, apoptosis, and synaptic damage by suppressing activation of the Akt/mTOR pathway. +other 32118734 hsa-mir-17 Colorectal Neoplasms Subsequently, paired formalin-fixed paraffin-embedded tissue samples of primary CRC and liver metastasis from 30 patients were examined for the expression of miRNAs common to these lists (hsa-miR-20a, hsa-miR-26b, hsa-miR-146a, hsa-miR-17, hsa-miR-451, hsa-miR-23a, and hsa-miR-29a) using quantitative real-time polymerase chain reaction. CONCLUSIONS: High expression of miR-17 may contribute to liver metastasis in CRC. +transcription factor target 32118359 hsa-mir-326 Asthma MiR-326 might be a promising novel therapeutic target for asthma. +transcription factor target 32118353 hsa-mir-373 Colonic Neoplasms We confirmed that proliferation and invasion of colon cancer cells are regulated in vitro and in vivo by miR-373 through targeting of the tumor suppressors TIMP2 and APC. Our data suggest that NE promotes colon cancer cell proliferation and metastasis by activating the CREB1-miR-373 axis. +other 32118052 hsa-mir-21 Schistosomiasis However, the role of miR-21 in the regulation of macrophage polarization by PZQ in schistosomiasis is still unclear. +lncRNA target 32117949 hsa-mir-221 Leukemia, Myeloid, Acute 3p in BMMSC-derived MVs regulated AML cell cycle, cell proliferation and invasion through targeting CDKN1C. +lncRNA target 32117757 hsa-mir-20a Liver Cirrhosis To uncover the underlying pro-inflammatory mechanism of miR-20a-5p in liver fibrosis, we selected and verified TGFBR2, which is a key functional receptor in TGF-beta signaling pathway, as a direct target gene of miR-20a-5p. +lncRNA target 32117734 hsa-mir-150 Carcinoma, Non-Small-Cell Lung Conclusions: Functional experiments revealed that LincRNA00494 inhibited NSCLC cell proliferation, which might be related to the suppression of SRCIN1, a tumor suppressor gene, by acting as a decoy for miR3p. +lncRNA target 32117723 hsa-mir-936 Squamous Cell Carcinoma of Head and Neck In summary, our study indicates that the miR-936/GPR78 axis could be both a diagnostic marker and a therapeutic target for LSCC. +circulation_biomarker_prognosis_ns 32117716 hsa-mir-122 Pancreatic Carcinoma Our data highlighted a role for circulating miR-1273g-3p and miR +genetics_overexpression_promote 32117588 hsa-mir-155 Breast Neoplasms Our current study suggests that in future DC vaccine development for breast cancer or other solid tumors, introducing forced miR155 overexpression in DCs via various approaches such as viral transduction or nanoparticle delivery, as well as including other adjuvant agents such as TLR ligands or immune stimulating cytokines, may unleash the full therapeutic potential of the DC vaccines. +genetics_knock down_suppress 32117463 hsa-mir-7 Prostatic Neoplasms Knockdown of these DelncRNAs in PCa cells also demonstrated the effects of RP11-423H2.3 on miR-7/miR-24/miR-30 or LAMTOR5-AS1 on miR +genetics_knock down_suppress 32117463 hsa-mir-942 Prostatic Neoplasms Knockdown of these DelncRNAs in PCa cells also demonstrated the effects of RP11-423H2.3 on miR-7/miR-24/miR-30 or LAMTOR5-AS1 on miR +genetics_knock down_suppress 32117463 hsa-mir-24 Prostatic Neoplasms Knockdown of these DelncRNAs in PCa cells also demonstrated the effects of RP11-423H2.3 on miR-7/miR-24/miR-30 or LAMTOR5-AS1 on miR +lncRNA target 32117091 hsa-mir-424 Dengue We observed that miR-424 suppresses expression of the E3 ubiquitin ligase SIAH1, which is normally induced during dengue virus 2 (DENV2) infection through activation of the unfolded protein response (UPR). +other 32116987 hsa-mir-384 Attention Deficit Disorder with Hyperactivity 5p may play a critical role in learning and memory impairment in ADHD. +genetics_overexpression_promote 32116696 hsa-mir-568 Reperfusion Injury TRIM62 overexpression or AG490, a selective inhibitor of JAK2/STAT3 significantly, significantly inhibited I/R and miR-3568 mimic induced cell apoptosis and STAT3 activation. +other 32116694 hsa-mir-96 Retinal Diseases Intravitreal supplementation of miR-96 mimic could constitute a novel therapeutic strategy to improve vascular repair in OIR and other ischemic retinopathies. +other 32116235 hsa-mir-222 Carcinoma, Renal Cell 3p mimic molecules significantly induced expression of EMT marker vimentin and downregulated E-cadherin in both 769-P and 786-O RCC cells. +other 32116235 hsa-mir-222 Endometrial Neoplasms 3p mimic molecules significantly induced expression of EMT marker vimentin and downregulated E-cadherin in both 769-P and 786-O RCC cells. +lncRNA target 32116112 hsa-mir-526b Carcinoma, Hepatocellular Mechanism research showed that hsa_circ_0091581 promoted cell proliferation via hsa_circ_0091581/miR-526b/c-Myc axis in HCC cells. These results revealed that hsa_circ_0091581/miR-526b/c-Myc/hsa_circ_0091581 positive feedback loop plays a vital role in HCC progression and hsa_circ_0091581 may be a potential prognostic biomarker and therapeutic target for HCC. +transcription factor target 32116109 hsa-mir-516a Urinary Bladder Neoplasms Although MIR516A has been reported to be downregulated and act as a tumor suppressor in multiple cancers, its expression and potential contribution to human bladder cancer (BC) remain unexplored. +lncRNA target 32116109 hsa-mir-516a-2 Urinary Bladder Neoplasms Collectively, our results reveal that MIR516A has a novel oncogenic function in BC growth by directing binding to PHLPP2 3'-UTR and inhibiting PHLPP2 expression, in turn at least partly promoting CUL4A-mediated BECN1 protein degradation, thereby attenuating autophagy and promoting BC growth, which is a distinct function of MIR516A identified in other cancers.Abbreviation: ATG3: autophagy related 3; ATG5: autophagy related 5; ATG7: autophagy related 7; ATG12: autophagy related 12; BAF: bafilomycin A(1); BC: bladder cancer; CHX: cycloheximide; Co-IP: co-immunoprecipitation; CUL3: cullin 3; CUL4A: cullin 4A; CUL4B: cullin 4B; IF: immunofluorescence: IHC-p: immunohistochemistry-paraffin; MIR516A: microRNA 516a (microRNA 516a1 and microRNA 516a2); MS: mass spectrometry; PHLPP2: PH domain and leucine rich repeat protein phosphatase. +genetics_knock down_suppress 32116075 hsa-mir-142 Diabetic Retinopathy 5p overexpression or IGF1 knockdown alleviated the pathological effects on retinal tissues in DR rats. +other 32115971 hsa-mir-10a Leukemia, Myelogenous, Chronic, BCR-ABL Positive CONCLUSION: Our data suggest that expression profiles of miR-10a, miR-150, and miRNA 148b were correlated as biomarker and therapeutic tool in Turkish patients with CML (Tab. +other 32115971 hsa-mir-148b Leukemia, Myelogenous, Chronic, BCR-ABL Positive CONCLUSION: Our data suggest that expression profiles of miR-10a, miR-150, and miRNA 148b were correlated as biomarker and therapeutic tool in Turkish patients with CML (Tab. +other 32115971 hsa-mir-150 Leukemia, Myelogenous, Chronic, BCR-ABL Positive CONCLUSION: Our data suggest that expression profiles of miR-10a, miR-150, and miRNA 148b were correlated as biomarker and therapeutic tool in Turkish patients with CML (Tab. +other 32115962 hsa-mir-126 Breast Neoplasms CONCLUSION: The miR-126 and miR-126* expressions differed according to benign and malign breast cancer cell lines. +lncRNA target 32115852 hsa-mir-671 Osteosarcoma Taken together, targeting miR +circulation_biomarker_diagnosis_ns 32115655 hsa-let-7g Hypertension CONCLUSIONS: We identified decreased circulating let-7g-5p and miR5p as independent biomarkers of CKD among patients with HTN, which could have pathophysiological and therapeutic implications. +circulation_biomarker_diagnosis_ns 32115655 hsa-mir-191 Hypertension CONCLUSIONS: We identified decreased circulating let-7g-5p and miR5p as independent biomarkers of CKD among patients with HTN, which could have pathophysiological and therapeutic implications. +genetics_knock down_promote 32115570 hsa-mir-195 Stomach Neoplasms 5p, Snail, vimentin and E-cadherin in SGC-7901 cells was measured, and then loss-of-function of miR +other 32115427 hsa-mir-146a Arthritis, Psoriatic 5p) were significantly higher in PsA compared to HC (all P < 0.05), with high specificity and sensitivity determined by receiver-operating characteristic curve analysis. +other 32115427 hsa-mir-26a Arthritis, Psoriatic 5p) were significantly higher in PsA compared to HC (all P < 0.05), with high specificity and sensitivity determined by receiver-operating characteristic curve analysis. +other 32115427 hsa-mir-221 Arthritis, Psoriatic 5p) were significantly higher in PsA compared to HC (all P < 0.05), with high specificity and sensitivity determined by receiver-operating characteristic curve analysis. +other 32115427 hsa-mir-130a Arthritis, Psoriatic 5p) were significantly higher in PsA compared to HC (all P < 0.05), with high specificity and sensitivity determined by receiver-operating characteristic curve analysis. +other 32115427 hsa-mir-21 Arthritis, Psoriatic 5p) were significantly higher in PsA compared to HC (all P < 0.05), with high specificity and sensitivity determined by receiver-operating characteristic curve analysis. +lncRNA target 32114955 hsa-mir-98 Mesothelioma Survival analysis revealed that high expression of only hsa-miR-98 was significantly associated with poor prognosis in patients with asbestos-exposed MPM. Evidence suggests that management of the aggressiveness and progression of asbestos-induced MPM may require high levels of hsa-miR-98 due to its tumor-suppressive role. +transcription factor target 32114898 hsa-mir-140 Platelet Storage Pool Deficiency Subsequent studies revealed that miR-140 mimics signi fi cantly inhibited CSFV replication, while the inhibition of endogenous miR-140 enhanced CSFV replication. In conclusion, this study demonstrated that CSFV inhibits miR-140 expression and miR-140 inhibits replication by binding to host factor Rab25. +lncRNA target 32114773 hsa-mir-455 Reperfusion Injury, Hepatic Ischemia Therefore, our findings show that the lncRNA Gm4419 accelerates hepatic I/R injury by targeting the miRSOX6 axis, which suggests a novel therapeutic target for hepatic I/R injury. +other 32114772 hsa-mir-138 Reperfusion Injury, Cerebral Ischemia To sum up, this study demonstrated that H19 promotes an inflammatory response and improves neurological function in a rat model of tMCAO by regulating the expression of miR5p and p65. +other 32114742 hsa-mir-450a Obesity BACKGROUND AND OBJECTIVES: miR-450a-5p was involved in fat formation, however, its role in insulin resistance remains unclear. In vitro cell experiments showed that MGO could not only promote the activity of endothelial cells, but also accelerate cell migration and fat accumulation, which, however, could be reversed by up-regulation of miR-450a-5p. +transcription factor target 32114742 hsa-mir-450a Diabetes Mellitus This study investigated the effects of miR-450a-5p on endothelial cells, with the aim of finding a potential target for diabetes mellitus. CONCLUSIONS: Up-regulated miR-450a-5p eliminates MGO-induced insulin resistance via targeting CREB, and therefore could be used as a potential target to improve insulin resistance and treat patients with diabetes-related diseases. +genetics_overexpression_promote 32114426 hsa-mir-4698 Carcinoma, Hepatocellular Trim59 was identified as a target of miR-4698 in miRDB, and consistent with this prediction, the expression of Trim59 was inversely correlated with that of miR-4698 in HCC, and miR-4698 overexpression led to a significant decrease in the luciferase activity of pRL-Trim59-3'-UTR but not mutant pRL-Trim59-3'-UTR. +lncRNA target 32114419 hsa-mir-129 Carcinoma, Non-Small-Cell Lung These findings suggest that the PCAT1/miR-129/ABCB1 axis may be a potential target for the treatment of DDP-resistant oat cell cancer. +circRNA target 32114390 hsa-mir-34a Intervertebral disc disease INTERPRETATION: Our results revealed that circRNA-CIDN binding to miR-34a-5p played an important role in mitigating compression loading-induced nucleus pulposus cell damage via targeting SIRT1, providing a potential therapeutic strategy for IDD treatment. +other 32113893 hsa-mir-27a Colorectal Neoplasms BACKGROUND & AIMS: An algorithm based on fecal levels of 2 microRNAs (miR-421 and miR-27a-3p), fecal hemoglobin concentration, and patient age and sex can identify patients with advanced colorectal neoplasia. +other 32113893 hsa-mir-421 Colorectal Neoplasms BACKGROUND & AIMS: An algorithm based on fecal levels of 2 microRNAs (miR-421 and miR-27a-3p), fecal hemoglobin concentration, and patient age and sex can identify patients with advanced colorectal neoplasia. +other 32113857 hsa-mir-214 Pre-Eclampsia The expression of miR5p was significantly increased in the placenta of patients with PE. +genetics_GWAS 32113822 hsa-mir-877 Carcinoma, Hepatocellular A genetic variant in the promoter region of miR-877 is associated with an increased risk of hepatocellular carcinoma. +genetics_GWAS 32112986 hsa-mir-27b Anxiety Disorders Effects of plasma concentration of micro-RNA Mir-27b and CYP3A4*22 on equilibrium concentration of alprazolam in patients with anxiety disorders comorbid with alcohol use disorder. OBJECTIVE The objective of our study was to investigate the effect of 99366316G>A polymorphism of the CYP3A4 gene on the concentration/dose indicator of alprazolam in patients with anxiety disorders comorbid with alcohol use disorder, using findings on enzymatic activity of CYP3A (as evaluated by the 6-beta-hydroxy-cortisol/cortisol ratio measurement) and on CYP3A4 expression level obtained by measuring the miR-27b plasma concentration levels in patients with anxiety disorders comorbid with alcoholism. +genetics_GWAS 32112986 hsa-mir-27b Alcoholism Effects of plasma concentration of micro-RNA Mir-27b and CYP3A4*22 on equilibrium concentration of alprazolam in patients with anxiety disorders comorbid with alcohol use disorder. OBJECTIVE The objective of our study was to investigate the effect of 99366316G>A polymorphism of the CYP3A4 gene on the concentration/dose indicator of alprazolam in patients with anxiety disorders comorbid with alcohol use disorder, using findings on enzymatic activity of CYP3A (as evaluated by the 6-beta-hydroxy-cortisol/cortisol ratio measurement) and on CYP3A4 expression level obtained by measuring the miR-27b plasma concentration levels in patients with anxiety disorders comorbid with alcoholism. +other 32112368 hsa-let-7i Breast Neoplasms RESULTS: Multilateral statistical assessment determined and repeatedly confirmed a specific panel of four urinary microRNA types (miR-424, miR-423, miR-660, and let7-i) as a highly specific combinatory biomarker tool discriminating BC patients from healthy controls, with 98.6% sensitivity and 100% specificity. +other 32112368 hsa-mir-423 Breast Neoplasms RESULTS: Multilateral statistical assessment determined and repeatedly confirmed a specific panel of four urinary microRNA types (miR-424, miR-423, miR-660, and let7-i) as a highly specific combinatory biomarker tool discriminating BC patients from healthy controls, with 98.6% sensitivity and 100% specificity. +other 32112368 hsa-mir-424 Breast Neoplasms RESULTS: Multilateral statistical assessment determined and repeatedly confirmed a specific panel of four urinary microRNA types (miR-424, miR-423, miR-660, and let7-i) as a highly specific combinatory biomarker tool discriminating BC patients from healthy controls, with 98.6% sensitivity and 100% specificity. +lncRNA target 32112145 hsa-mir-155 Heart Diseases miR-155 was transferred to endothelial cells (ECs), leading to the inhibition of angiogenesis and cardiac dysfunction by downregulating its novel target genes, including Rac family small GTPase 1 (RAC1), p21 (RAC1)-activated kinase 2 (PAK2), Sirtuin 1 (Sirt1), and protein kinase AMP-activated catalytic subunit alpha 2 (AMPKalpha2). +lncRNA target 32111564 hsa-mir-219 familial temporal lobe epilepsy 3 Therefore, the goal of this study was to evaluate the differential expression of miR-219, miR-181b, and miR-195, previously described as regulators of the excitatory neurotransmitter receptors NMDA-R1 and AMPA-GluR2 and inhibitory neurotransmitter GABA(A) (alpha2, beta3, and gamma2 subunits) in the amygdala and hippocampus of patients with mesial temporal lobe epilepsy. +lncRNA target 32111564 hsa-mir-195 familial temporal lobe epilepsy 3 Therefore, the goal of this study was to evaluate the differential expression of miR-219, miR-181b, and miR-195, previously described as regulators of the excitatory neurotransmitter receptors NMDA-R1 and AMPA-GluR2 and inhibitory neurotransmitter GABA(A) (alpha2, beta3, and gamma2 subunits) in the amygdala and hippocampus of patients with mesial temporal lobe epilepsy. +lncRNA target 32111564 hsa-mir-181b familial temporal lobe epilepsy 3 Therefore, the goal of this study was to evaluate the differential expression of miR-219, miR-181b, and miR-195, previously described as regulators of the excitatory neurotransmitter receptors NMDA-R1 and AMPA-GluR2 and inhibitory neurotransmitter GABA(A) (alpha2, beta3, and gamma2 subunits) in the amygdala and hippocampus of patients with mesial temporal lobe epilepsy. +genetics_overexpression_suppress 32111444 hsa-mir-129 Glioma 5p overexpression inhibited glioma proliferation, migration and invasion. +other 32111353 hsa-mir-532 Muscular Dystrophy, Duchenne RESULTS: MiR3p expression boosted in low bone mineral density (BMD) patients and rats. +other 32111353 hsa-mir-532 Osteoporosis METHODS: We analyzed the content of miR3p in osteoporosis patients, osteoporosis rats, and osteogenic induced MC3T3-E1 cells. +other 32111353 hsa-mir-532 Bone Diseases, Metabolic RESULTS: MiR3p expression boosted in low bone mineral density (BMD) patients and rats. +transcription factor target 32111144 hsa-mir-363 Osteoporosis Taken together, these results uncovered the mechanism by which TRAF3 promotes BMSC osteogenic differentiation and suppresses adipogenic differentiation and senescence, indicating that the miR3p-TRAF3 axis might be a novel therapeutic target for BMSC-based bone tissue engineering in osteoporosis. +other 32111074 hsa-mir-9 Adenocarcinoma of Lung miR-9 expression was analyzed in 16 pleural effusions containing metastatic cells from lung adenocarcinoma and was significantly reduced in patients from the 'Low lamin A expression' group compared to patients from the 'High lamin A expression' group. These results suggest that miR-9 does not regulate lamin A expression in metastatic cells from lung adenocarcinoma. +lncRNA target 32111031 hsa-mir-193b Osteoarthritis, Knee 3p and miR-193b-3p) suggested a strong capacity for ASCs to reduce matrix degradation activities, as those activated in OA cartilage, and switch synovial macrophages, often characterized by an M1 inflammatory polarization, towards an M2 phenotype. +lncRNA target 32111031 hsa-mir-222 Osteoarthritis, Knee 3p and miR-193b-3p) suggested a strong capacity for ASCs to reduce matrix degradation activities, as those activated in OA cartilage, and switch synovial macrophages, often characterized by an M1 inflammatory polarization, towards an M2 phenotype. +lncRNA target 32111031 hsa-mir-24 Osteoarthritis, Knee 3p and miR-193b-3p) suggested a strong capacity for ASCs to reduce matrix degradation activities, as those activated in OA cartilage, and switch synovial macrophages, often characterized by an M1 inflammatory polarization, towards an M2 phenotype. +other 32110930 hsa-mir-33a Hypertrophy Manipulation of the levels of miR-33a and SREBPs allowed us to understand their involvement in cell death and hypertrophy. +lncRNA target 32110804 hsa-mir-2110 Breast Neoplasms Moreover, ARAP1-AS1 could boost HDAC2 expression in BC through sponging miR-2110 via a ceRNA mechanism. To sum up, ARAP1-AS1 serves a tumor-promoter in BC development through modulating miR-2110/HDAC2/PLIN1 axis, which may help to develop novel effective targets for BC treatment. +transcription factor target 32110359 hsa-mir-21 Drug Hypersensitivity Moreover, the DTNSs could also act as an anti-cancer drug; antagomir-21 (one recognition sequence) was detached from DTNSs to silence endogenous miRNA-21 inside cells, which would suppress cancer cell migration and invasion, and finally induce cancer cell apoptosis; the result was demonstrated by experiments in vitro and in vivo. +lncRNA target 32110100 hsa-mir-140 Stomach Neoplasms 5p/SOX4 axis, and may serve as a novel therapeutic target for GC. +genetics_overexpression_promote 32110099 hsa-mir-32 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma The results of the ROC curve analysis indicated that overexpression of miR-32 might be used to distinguish T-ALL patients with reasonable sensitivity and specificity. +lncRNA target 32110097 hsa-mir-205 Osteosarcoma 5p to promote c-FLIP expression, thereby enhancing EMT and inducing OS invasion and metastasis in vitro, implying that circPVT1 might be a potential therapeutic target for further clinical therapy of OS. +other 32110096 hsa-mir-92a Carcinoma, Endometrioid HEC-1 cells were transfected with DCST1-AS1, Notch1 vectors, miRNA negative control or miR-92a-3p mimic. DISCUSSION: DCST1-AS1 is downregulated in EC and may sponge miR-92a-3p, thereby promoting cancer cell invasion and migration. +lncRNA target 32110074 hsa-mir-146a Diabetic Neuropathies CONCLUSION: LncRNAs may contribute to the pathogenesis of DPN by regulating inflammation through functioning as ceRNAs of miR-146a-5p. +genetics_overexpression_promote 32110059 hsa-mir-1294 Osteosarcoma Moreover, we demonstrated that PKM2 was a target of miR-1294 in osteosarcoma cells, and the effects caused by miR-1294 mimic were reversed by the overexpression of PKM2. +other 32110057 hsa-mir-107 Stomach Neoplasms Moreover, circHIPK3 was identified as a sponge of miR-107, and as such it regulated brain-derived neurotrophic factor (BDNF), which plays a pivotal role in the development of GC. +genetics_overexpression_suppress 32110056 hsa-mir-26b Thyroid Cancer, Papillary In vitro, we established cell lines stably overexpressing miR-26b-5p and investigated the function and underlying mechanism of miR-26b-5p in PTC. +genetics_overexpression_promote 32110054 hsa-mir-940 Thyroid Neoplasms MiR-940 could be absorbed by circ_0058124, and the inhibition effect of its overexpression on TC progression could be reversed by overexpressed-circ_0058124. +other 32110050 hsa-mir-520a Carcinoma, Non-Small-Cell Lung CONCLUSION: LncRNA NORAD can regulate the proliferation of NSCLC by regulating miR-520a-3p/PI3k/Akt/mTOR signaling pathway, thus promoting the occurrence and development of NSCLC. +lncRNA target 32110048 hsa-mir-124 Colorectal Neoplasms HNF1A-AS1 regulated MYO6 expression via targeting miR-124 in CRC cells. +lncRNA target 32110042 hsa-mir-424 Glioma Besides, pcDNA3.1-CCAT2 and miR-424 inhibitor could enhance tolerance of glioma cell lines against drugs (P<0.05). +transcription factor target 32109943 hsa-mir-1 Pulmonary Arterial Hypertension Taken together, these data suggest that miR-1 targets TGF-betaR1 and reduces TGF-beta signalling, so a reduction in miR-1 expression may increase TGF-beta signalling and contribute to cardiac hypertrophy. +transcription factor target 32109943 hsa-mir-1 Cardiomegaly Taken together, these data suggest that miR-1 targets TGF-betaR1 and reduces TGF-beta signalling, so a reduction in miR-1 expression may increase TGF-beta signalling and contribute to cardiac hypertrophy. +transcription factor target 32109664 hsa-mir-140 Hypercholesterolemia Simvastatin inhibits hsa-miR +genetics_overexpression_promote 32109492 hsa-mir-139 Pancreatic Carcinoma 5p overexpression could suppress PANC tumor growth and the expressions of SLC7A11, p-PI3K, p-Akt in tumor tissues. +lncRNA target 32109290 hsa-mir-139 Stomach Neoplasms 5p inhibitor showed opposite effects. +genetics_overexpression_promote 32109249 hsa-mir-182 Carcinoma, Renal Cell The analyses showed that chromophobe renal tumors are a homogeneous group characterized by an overexpression of miR 1229, miR 10a, miR 182, miR 1208, miR 222, miR 221, miR 891b, miR 629-5p and miR 221-5p. +genetics_overexpression_promote 32109249 hsa-mir-221 Carcinoma, Renal Cell The analyses showed that chromophobe renal tumors are a homogeneous group characterized by an overexpression of miR 1229, miR 10a, miR 182, miR 1208, miR 222, miR 221, miR 891b, miR 629-5p and miR 221-5p. +genetics_overexpression_promote 32109249 hsa-mir-10a Carcinoma, Renal Cell The analyses showed that chromophobe renal tumors are a homogeneous group characterized by an overexpression of miR 1229, miR 10a, miR 182, miR 1208, miR 222, miR 221, miR 891b, miR 629-5p and miR 221-5p. +genetics_overexpression_promote 32109249 hsa-mir-222 Carcinoma, Renal Cell The analyses showed that chromophobe renal tumors are a homogeneous group characterized by an overexpression of miR 1229, miR 10a, miR 182, miR 1208, miR 222, miR 221, miR 891b, miR 629-5p and miR 221-5p. +genetics_overexpression_promote 32109249 hsa-mir-891b Carcinoma, Renal Cell The analyses showed that chromophobe renal tumors are a homogeneous group characterized by an overexpression of miR 1229, miR 10a, miR 182, miR 1208, miR 222, miR 221, miR 891b, miR 629-5p and miR 221-5p. +genetics_overexpression_promote 32109249 hsa-mir-1229 Carcinoma, Renal Cell The analyses showed that chromophobe renal tumors are a homogeneous group characterized by an overexpression of miR 1229, miR 10a, miR 182, miR 1208, miR 222, miR 221, miR 891b, miR 629-5p and miR 221-5p. +circulation_biomarker_diagnosis_ns 32109146 hsa-mir-539 Adenocarcinoma of Lung In subjects carrying the G allele, the expression of lncRNA MALAT1 in plasma is significantly decreased, resulting in an abnormally high expression of hsa-miR +circulation_biomarker_diagnosis_ns 32109146 hsa-mir-539 Hypertension In subjects carrying the G allele, the expression of lncRNA MALAT1 in plasma is significantly decreased, resulting in an abnormally high expression of hsa-miR +circulation_biomarker_diagnosis_ns 32109146 hsa-mir-485 Adenocarcinoma of Lung In subjects carrying the G allele, the expression of lncRNA MALAT1 in plasma is significantly decreased, resulting in an abnormally high expression of hsa-miR +circulation_biomarker_diagnosis_ns 32109146 hsa-mir-485 Hypertension In subjects carrying the G allele, the expression of lncRNA MALAT1 in plasma is significantly decreased, resulting in an abnormally high expression of hsa-miR +transcription factor target 32108985 hsa-mir-21 Brain Injuries, Traumatic In this study, we explored neuroprotection of hydrogen-rich medium through activation of the miR-21/PI3K/AKT/GSK-3beta pathway in an in vitro model of traumatic brain injury. In conclusion, hydrogen exerted a neuroprotective effect against neuronal apoptosis and impaired nerve regeneration through activation of miR-21/PI3K/AKT/GSK-3beta signalling in this in vitro model of traumatic brain injury. +lncRNA target 32108968 hsa-mir-21 Obesity MiRNA-21 could be one of the mechanistic links between obesity and diastolic dysfunction through regulating cardiac fibrosis via TGF-beta1/Smad signaling pathway in obese hearts, which may serve as a novel target of disease intervention. +lncRNA target 32108968 hsa-mir-21 Heart Failure, Diastolic MiRNA-21 could be one of the mechanistic links between obesity and diastolic dysfunction through regulating cardiac fibrosis via TGF-beta1/Smad signaling pathway in obese hearts, which may serve as a novel target of disease intervention. +other 32108448 hsa-mir-636 Lymphoma Furthermore, AAV6 serotype vectors encoding an inducible caspase 9 suicide gene, packaged in the presence of miR-636, showed a significant tumor regression (~2.2-fold, P < .01) in a syngeneic murine model of T-cell lymphoma. +other 32108372 hsa-mir-1299 Carcinoma, Hepatocellular "Retraction: ""Hsa_circ_0003645 shows an oncogenic role by sponging microRNA-1299 in hepatocellular carcinoma cells"", by Qiuyun Yu, Jinhua Dai, Ming Shu, Journal of Clinical Laboratory Analysis, 2020, e23249 (https://doi.org/10.1002/jcla.23249)." +exosome 32108166 hsa-mir-629 Adenocarcinoma of Lung Besides, exosomal-miR +other 32108040 hsa-mir-146a Precursor Cell Lymphoblastic Leukemia-Lymphoma CONCLUSION: MiR146a rs2910164 G allele serves as a protective marker for childhood ALL in Taiwan. +circulation_biomarker_prognosis_ns 32107956 hsa-mir-125b Carcinoma, Ovarian Epithelial This study demonstrated that serum miR-125b levels were a useful diagnostic biomarker and biomarker to predict the responses to chemotherapy in patients with EOC. +other 32107941 hsa-mir-23b Melanoma MiR-23b is a prognostic factor in melanoma. +other 32107907 hsa-mir-142 Urinary Bladder Neoplasms 3p affects the proliferation, migration and invasion of bladder cancer cells by regulating Rac1. +genetics_overexpression_promote 32107877 hsa-mir-138 Prostatic Neoplasms We confirmed that overexpression of FOXC1 partially reversed the effects of MIR +circRNA target 32107851 hsa-mir-1270 Carcinoma, Non-Small-Cell Lung CONCLUSION: Circ-IGF1R may inhibit lung cancer invasion and migration through a potential network of circ-IGF1R-miR +other 32107606 hsa-mir-106a Rhabdomyosarcoma 1 CONCLUSION: H19/miR-106a-5p/VEGFA axis plays a role in regulating the angiogenic capacity of EVT, which might contribute to idiopathic RM. +other 32107606 hsa-mir-106a rippling muscle disease 1 CONCLUSION: H19/miR-106a-5p/VEGFA axis plays a role in regulating the angiogenic capacity of EVT, which might contribute to idiopathic RM. +other 32107471 hsa-mir-146a Primary Myelofibrosis Low levels of miR-146a contribute to the MF phenotype by increasing Stat3 signaling. +lncRNA target 32107418 hsa-mir-206 Endometrial Neoplasms In conclusion, downregulation of miR-206 and upregulation of HDAC6 in EC may predict poor prognosis, and as the target gene of miR-206, HDAC achieves its carcinogenic effect through the PTEN/AKT/mTOR pathway. +lncRNA target 32107086 hsa-mir-145 Colorectal Neoplasms 5p could act as a tumor suppressor in CRC by targeting CDCA3, and serve as a diagnostic and therapeutic biomarker of CRC. +lncRNA target 32107085 hsa-mir-595 Carcinoma, Hepatocellular Finally, we showed that miR-595 inhibited the NF-kappaB pathway by suppressing ABCB1 expression in HCC cells. +other 32106859 hsa-mir-522 Stomach Neoplasms The intercellular pathway, comprising USP7, hnRNPA1, exo-miR-522 and ALOX15, reveals new mechanism of acquired chemo-resistance in GC. +other 32106776 hsa-mir-192 Urinary Bladder Neoplasms The microRNA-192 expression in urinary sediment is valuable in the diagnosis of bladder cancer, which shows high sensitivity in diagnosis of bladder cancer when combined with B-ultrasound. +lncRNA target 32106739 hsa-mir-214 Uterine Cervical Neoplasms 5p expression alleviated such an inhibition. +other 32106598 hsa-mir-425 Infertility 5p, miR-191, miR-92b-5p and miR-15b miRNAs, and (ii) the presence of 347 up-regulated and 174 down-regulated RNA transcripts in high-fertility breeding boars, based on differences of farrowing rate (FS) and litter size (LS), relative to low-fertility boars in the (Artificial Insemination) AI program. +other 32106598 hsa-mir-92a Infertility 5p, miR-191, miR-92b-5p and miR-15b miRNAs, and (ii) the presence of 347 up-regulated and 174 down-regulated RNA transcripts in high-fertility breeding boars, based on differences of farrowing rate (FS) and litter size (LS), relative to low-fertility boars in the (Artificial Insemination) AI program. +other 32106598 hsa-mir-621 Infertility Moreover, two micro-RNAs (miR-221 and mir-621) were down- and up-regulated, respectively, in high-fertility males. +other 32106598 hsa-mir-221 Infertility Moreover, two micro-RNAs (miR-221 and mir-621) were down- and up-regulated, respectively, in high-fertility males. +other 32106598 hsa-mir-15b Infertility 5p, miR-191, miR-92b-5p and miR-15b miRNAs, and (ii) the presence of 347 up-regulated and 174 down-regulated RNA transcripts in high-fertility breeding boars, based on differences of farrowing rate (FS) and litter size (LS), relative to low-fertility boars in the (Artificial Insemination) AI program. +other 32106598 hsa-mir-92b Infertility 5p, miR-191, miR-92b-5p and miR-15b miRNAs, and (ii) the presence of 347 up-regulated and 174 down-regulated RNA transcripts in high-fertility breeding boars, based on differences of farrowing rate (FS) and litter size (LS), relative to low-fertility boars in the (Artificial Insemination) AI program. +other 32106598 hsa-mir-191 Infertility 5p, miR-191, miR-92b-5p and miR-15b miRNAs, and (ii) the presence of 347 up-regulated and 174 down-regulated RNA transcripts in high-fertility breeding boars, based on differences of farrowing rate (FS) and litter size (LS), relative to low-fertility boars in the (Artificial Insemination) AI program. +other 32106598 hsa-mir-16 Infertility 5p, miR-191, miR-92b-5p and miR-15b miRNAs, and (ii) the presence of 347 up-regulated and 174 down-regulated RNA transcripts in high-fertility breeding boars, based on differences of farrowing rate (FS) and litter size (LS), relative to low-fertility boars in the (Artificial Insemination) AI program. +other 32106598 hsa-mir-4332 Infertility 5p, miR-191, miR-92b-5p and miR-15b miRNAs, and (ii) the presence of 347 up-regulated and 174 down-regulated RNA transcripts in high-fertility breeding boars, based on differences of farrowing rate (FS) and litter size (LS), relative to low-fertility boars in the (Artificial Insemination) AI program. +other 32106535 hsa-mir-9 Nerve Degeneration Therefore, it is strongly anticipated that the induction method combining Ngn2 and miR-9/9*-124 will enable more rapid and simple screening for various types of neuronal disease phenotypes and promote drug discovery. +genetics_knock down_suppress 32106526 hsa-mir-375 Carcinoma, Merkel Cell In summary, highly effective miR-375 knockdown in classical MCC cell lines did not significantly change the cell viability, morphology, or oncogenic signaling pathways. +genetics_knock down_promote 32106373 hsa-mir-451a Lung Neoplasms Furthermore, c-Myc knockdown markedly elevated the sensitivity of lung cancer cells to DOX, whereas over-expressing c-Myc markedly reversed the anti-tumor role of DOX, which was slightly diminished by miR-451a mimic. +lncRNA target 32106369 hsa-mir-134 Carcinoma, Hepatocellular Collectively, we determined that MFI2-AS1 crucially acted in HCC progression via functioning as miR-134 sponge to upregulating FOXM1 expression, and was conducive to the promotion of better understanding the direct diagnostics and iatreusiology of lncRNA in HCC. +genetics_overexpression_promote 32106367 hsa-mir-21 Hyperglycemia 5p was upregulated in XIST-overexpressed ARPE-19 cells to further assess the functional correlation between XIST and hsa-miR +circulation_biomarker_diagnosis_up 32106257 hsa-mir-379 Non-alcoholic Fatty Liver Disease The correlation between serum miR-379 and cholesterol levels was lost in early stage NAFLD patients treated with statins. +circulation_biomarker_diagnosis_up 32106257 hsa-mir-379 Hypercholesterolemia The correlation between serum miR-379 and cholesterol levels was lost in early stage NAFLD patients treated with statins. +transcription factor target 32105659 hsa-mir-135a Uterine Cervical Neoplasms Interestingly, the expression of miR-135a was upregulated in the human cervical cancer cells and its suppression exerted growth inhibitory effects on the C33A and HeLa cells. +lncRNA target 32105410 hsa-mir-542 Osteosarcoma 5p mimics or inhibitor revealed that miR +lncRNA target 32104945 hsa-mir-545 Inflammation This research indicated that the highly expressed circPRKCI relieved inflammatory injury induced by LPS in HK2 cells by suppressing miR-545/ZEBs and depressing the briskness of NF-kB pathway. +other 32104700 hsa-mir-431 Esophageal Neoplasms 5p) is a potential novel prognostic biomarker for ESCA. +other 32104700 hsa-mir-1301 Esophageal Neoplasms 5p) is a potential novel prognostic biomarker for ESCA. +other 32104700 hsa-mir-769 Esophageal Neoplasms 5p) is a potential novel prognostic biomarker for ESCA. +genetics_overexpression_promote 32104694 hsa-mir-654 Colorectal Neoplasms Rescue experiments showed overexpression of HAX-1 could partially reversed the effects of miR +genetics_overexpression_suppress 32104674 hsa-mir-1826 Osteosarcoma CONCLUSION: The decreased expression of miR-1826 predicts a poor prognosis in OS patients, and its overexpression inhibits OS cell proliferation, migration, and invasion. +transcription factor target 32104542 hsa-mir-130a Diabetic Nephropathies Our results suggest that metformin reduces the senescence of renal tubular epithelial cells in diabetic nephropathy via the MBNL1/miR-130a-3p/STAT3 pathway, which provided new ideas for the therapy of this disease. +lncRNA target 32104496 hsa-mir-27b Colorectal Neoplasms These results suggest that miR-27b-3p is not only a potential indicator for evaluating efficiency of chemotherapy, but also a valuable therapeutic target for CRC, especially for patients with chemoresistance. +lncRNA target 32104302 hsa-mir-9 Osteoarthritis Taken together, these results suggest that direct targeting of the MALAT1/miR-9/NF-kappaB1/IL-6, MMP-13/caspase-3 axis may be a novel therapeutic strategy for the treatment of OA. +other 32104288 hsa-mir-489 Cardiomyopathies Taken together, the results obtained in the present study revealed that the miR-489/HDAC2 signaling pathway may serve as a novel regulatory mechanism in ISO-induced cardiac fibrosis and may increase the understanding on cardiac fibrosis. +other 32104287 hsa-mir-1973 Burns 3p were downregulated following thermal injury of the human EpSCs. +other 32104287 hsa-mir-6868 Burns 3p were downregulated following thermal injury of the human EpSCs. +other 32104287 hsa-mir-191 Burns 3p were downregulated following thermal injury of the human EpSCs. +other 32104287 hsa-mir-4461 Burns 3p were downregulated following thermal injury of the human EpSCs. +other 32104287 hsa-mir-4485 Burns 3p were downregulated following thermal injury of the human EpSCs. +other 32104287 hsa-mir-548 Burns 3p were downregulated following thermal injury of the human EpSCs. +other 32104287 hsa-mir-129 Burns 3p were downregulated following thermal injury of the human EpSCs. +other 32104287 hsa-mir-147b Burns 3p were downregulated following thermal injury of the human EpSCs. +other 32104287 hsa-mir-4520 Burns 3p were downregulated following thermal injury of the human EpSCs. +transcription factor target 32104279 hsa-mir-21 Wilms Tumor miR-21 affects the proliferation and apoptosis of WT SK-NEP-1 cells via the PTEN/Akt pathway. +other 32104274 hsa-mir-130a Cerebral Infarction The expression level of miR-130a in brain tissues of CI rats is significantly increased. +transcription factor target 32104266 hsa-mir-584 Uterine Cervical Neoplasms Therefore, miR-584 acted as a tumor suppressor miRNA and might be a novel target gene for future cervical cancer treatments. +genetics_overexpression_suppress 32104257 hsa-mir-181a Neonatal Sepsis In conclusion, decreased serum levels of miR-181a may serve as a diagnostic biomarker in patients with NS and overexpression of miR-181a inhibits the LPS-induced inflammatory response at least partially by targeting TLR4. +circulation_biomarker_prognosis_up 32104255 hsa-mir-27a Multiple Organ Failure The present results suggested that serum miR-27a level may be a potential novel diagnostic and prognostic factor for MODS caused by paraquat poisoning. +genetics_overexpression_suppress 32104249 hsa-mir-145 Kidney Diseases These results indicate that miR5p overexpression inhibited the Notch signaling pathway and podocyte lesions induced by HG. +other 32104249 hsa-mir-145 Norrie disease 5p may offer a novel approach for the treatment of DN. +genetics_overexpression_suppress 32104249 hsa-mir-145 Hyperglycemia 5p overexpression inhibited the Notch signaling pathway and podocyte lesions induced by HG. +genetics_knock down_suppress 32104236 hsa-mir-200c Prostatic Neoplasms Knockdown of AMACR by RNA interference, or overexpression of miR200c by recombinant adenoviral Ad-miR200c, inhibited prostate cancer cell proliferation, migration and invasiveness. +transcription factor target 32104235 hsa-mir-103a Carcinoma, Non-Small-Cell Lung In the present study, it was revealed that there were increased expression levels of miR-103a-3p in both NSCLC cell lines and human NSCLC samples that exhibited resistance to cisplatin. In conclusion, NF1 was identified as a special miR-103a-3p target in the present study, and it was revealed that targeting NF1 via miR-103a-3p may help reverse chemoresistance and provide a biomarker to cisplatin responsiveness in NSCLC. +circulation_biomarker_diagnosis_ns 32104219 hsa-mir-222 Uterine Cervical Neoplasms Expression of ALDH1 mRNA and protein was elevated in cervical cancer tissues and peripheral blood from patients compared with tumor-adjacent tissues and healthy controls, while the expression of miR-222 was reduced. +other 32104217 hsa-mir-21 Hypoxia In the present study, the role of miR21 in the underlying mechanism of salidroside-induced protection against oxidative stress and inflammatory injuries in hypoxia/reoxygenation (H/R)-treated H9c2 cardiomyocytes was determined. +other 32104217 hsa-mir-21 Inflammation In the present study, the role of miR21 in the underlying mechanism of salidroside-induced protection against oxidative stress and inflammatory injuries in hypoxia/reoxygenation (H/R)-treated H9c2 cardiomyocytes was determined. +genetics_knock down_suppress 32104215 hsa-mir-133a Glioma Overexpression of miR-133a inhibited glioma proliferation, metastasis and EMT via reducing the expression of SOX4; in contrast, knockdown of miR-133a exhibited the opposite effect, which revealed that miR-133a negatively regulates glioma progression. +lncRNA target 32104095 hsa-mir-125a Glioma A miR-125a-5p inhibitor restored BCYRN1 siRNA function in glioma. Mechanistically, upregulated expression of BCYRN1 in glioma acts as a sponge to sequester the endogenous tumor suppressor miR-125a-5p and to further increase the expression TAZ. +genetics_knock down_promote 32104094 hsa-mir-135a Prostatic Neoplasms Moreover, the function of miR-135a-5p mimic in PCa cells was consistent with ZFAS1 knockdown, while the function of miR-135a-5p inhibitor was opposite to that of miR-135a-5p mimic in PCa cells. +genetics_overexpression_promote 32104093 hsa-mir-20 Carcinoma, Non-Small-Cell Lung In NSCLC cells, HCP5 overexpression led to the up-regulated survivin and down-regulated miR-320. +tissue_expression_ns 32104079 hsa-mir-146a Esophageal Squamous Cell Carcinoma We aimed to evaluate miR146a expression as a prognostic or diagnostic biomarker for esophageal squamous cell carcinoma (ESCC) and also an association between miR146a and COX2 expression. MATERIALS AND METHODS: We quantified the level of miR-146a and COX-2 expression in cancerous and adjacent normal tissue samples obtained from 34 patients with ESCC, using real-time-PCR. The association between miR-146a and COX2 expression level in ESCC patients was evaluated by nonparametric Spearman's rho analysis. Survival analysis by Kaplan-Meier method showed miR146a and COX2 expression can be probably considered as prognostic biomarkers for ESCC because patients with high expression of miR146a had 7 months shorter life span and patients with low expression of COX2 had 8 months shorter life span. MiR-146a and COX2 expression can probably be considered as prognostic biomarkers for survival in ESCC. +genetics_knock down_suppress 32104074 hsa-mir-30 Pancreatic Carcinoma CircHIPK3 knockdown of RASSF1 expression could neutralize the cytological function of PC cells by miR +circulation_biomarker_diagnosis_ns 32104069 hsa-mir-21 Breast Neoplasms The objectives of this study were to characterize mir21, miR31, mir143, mir145, and control RNU43, which are differentially expressed in peripheral blood mononuclear cells (PBMCs) of breast and colorectal cancer patients, compared to that in controls and to establish whether this is specific to breast and colon cancer for use as tumor markers. +circulation_biomarker_diagnosis_ns 32104069 hsa-mir-143 Breast Neoplasms The objectives of this study were to characterize mir21, miR31, mir143, mir145, and control RNU43, which are differentially expressed in peripheral blood mononuclear cells (PBMCs) of breast and colorectal cancer patients, compared to that in controls and to establish whether this is specific to breast and colon cancer for use as tumor markers. +circulation_biomarker_diagnosis_ns 32104069 hsa-mir-1 Breast Neoplasms The objectives of this study were to characterize mir21, miR31, mir143, mir145, and control RNU43, which are differentially expressed in peripheral blood mononuclear cells (PBMCs) of breast and colorectal cancer patients, compared to that in controls and to establish whether this is specific to breast and colon cancer for use as tumor markers. +circulation_biomarker_diagnosis_ns 32104069 hsa-mir-145 Breast Neoplasms The objectives of this study were to characterize mir21, miR31, mir143, mir145, and control RNU43, which are differentially expressed in peripheral blood mononuclear cells (PBMCs) of breast and colorectal cancer patients, compared to that in controls and to establish whether this is specific to breast and colon cancer for use as tumor markers. +lncRNA target 32104067 hsa-mir-2467 Uterine Cervical Neoplasms CONCLUSION: Our findings demonstrated that LINC01410 contributed to CC progression through regulating miR-2467/VOPP1 axis and suggested that LINC01410/miR-2467/VOPP1 cascade may be a potential therapeutic target. +circulation_biomarker_diagnosis_up 32104033 hsa-mir-506 Norrie disease 3p was downregulated in the plasma of patients with DN and HG-induced HK-2 cells and KCNQ1OT1 interference promoted the expression of miR +genetics_overexpression_promote 32104033 hsa-mir-506 Necrobiotic Disorders 3p overexpression suppressed the inflammation, oxidative stress and pyroptosis of HG-induced HK-2 cells. +genetics_knock down_promote 32104001 hsa-mir-22 Stomach Neoplasms 3p or overexpression of ZFP91. +circulation_biomarker_diagnosis_ns 32103998 hsa-mir-146b Thyroid Cancer, Papillary CONCLUSION: Plasma exosomal miR-146b-5p and miR +circulation_biomarker_diagnosis_ns 32103998 hsa-mir-222 Thyroid Cancer, Papillary CONCLUSION: Plasma exosomal miR-146b-5p and miR +genetics_overexpression_promote 32103996 hsa-mir-193a Leukemia, Myeloid, Acute Overexpressed miR-193a-5p resulted in the decrease of cell viability and the increase in the cell death in AML cells. +lncRNA target 32103992 hsa-mir-1246 Melanoma CONCLUSION: MiR-1246 promoted cell viability and metastasis in melanoma by inhibiting FOXA2 expression. +genetics_knock down_promote 32103988 hsa-mir-4999 Colorectal Neoplasms 5p targeted PRKAA2 to exert its tumor-promoting functions, and PRKAA2 knockdown rescued decreased cell proliferation and glycolysis in miR +genetics_overexpression_suppress 32103984 hsa-mir-543 Uterine Cervical Neoplasms The overexpression of PCAT6 reversed the inhibitory effects of miR-543 accumulation on the proliferation, metastasis and chemoresistance of CC cells to cisplatin and the promoting impact on the apoptosis of CC cells. +lncRNA target 32103980 hsa-mir-218 Uterine Cervical Neoplasms CONCLUSION: HULC promotes cervical cancer cell proliferation, migration and invasion via miR-218/TPD52 axis. +circulation_biomarker_prognosis_down 32103875 hsa-mir-1304 Esophageal Neoplasms RESULTS: The expression of miR-1304 in the tissues and serum of patients with esophageal carcinoma increased, and was also increased according to the database. +lncRNA target 32103872 hsa-mir-19a Colorectal Neoplasms Thus, miR-19a-3p is likely to be a therapeutic target in CRC. +genetics_GWAS 32103099 hsa-mir-499a Breast Neoplasms Numerous studies have investigated the association of MIR499A rs3746444 polymorphism with breast cancer susceptibility, but the results have been inconsistent. In conclusion, MIR499A rs3746444 polymorphism was significantly associated with breast cancer susceptibility among Asians, suggesting its potential use as a genetic risk marker in this population. +circulation_biomarker_diagnosis_ns 32102886 hsa-mir-509 Respiratory Syncytial Virus Infections We also found that NRAV competed with vesicle protein Rab5c for microRNA miR509-3p in cytoplasm to promote RSV vesicle transport and accelerate RSV proliferation, thereby improving our understanding of the pathogenic mechanism of RSV infection. +other 32102877 hsa-mir-124 Sexually Transmitted Diseases We identified 16 miRNAs showing a positive effect on Sindbis virus (SINV) expressing green fluorescent protein (GFP), among which were a number of neuron-specific ones such as miR-124. Using a genome-wide miRNA screen, we identified neuronal miR-124 as a positive regulator of the Sindbis and chikungunya alphaviruses. +other 32102688 hsa-mir-195 Myeloproliferative Disorder, Chronic, with Eosinophilia 5p and miR-34a-5p can become potential diagnostic biomarkers for MPE with further evidences. +other 32102688 hsa-mir-182 Myeloproliferative Disorder, Chronic, with Eosinophilia 5p and miR-34a-5p can become potential diagnostic biomarkers for MPE with further evidences. +other 32102688 hsa-mir-34a Myeloproliferative Disorder, Chronic, with Eosinophilia 5p and miR-34a-5p can become potential diagnostic biomarkers for MPE with further evidences. +genetics_knock down_suppress 32102682 hsa-mir-144 Carcinoma, Non-Small-Cell Lung METHODS: We first quantified the levels of miR-144, CCNE1, and CCNE2 in NSCLC tissues and cell lines and then undertook gain- and loss-of-function studies of miR-144, CCNE1, and CCNE2 to investigate their roles in the biological characteristics of NSCLC in vitro. +lncRNA target 32102656 hsa-mir-204 Carcinoma, Non-Small-Cell Lung 5p in the course of NSCLC were identified by estimated target prediction and analysis. +lncRNA target 32102564 hsa-mir-192 Cardiomyopathies In conclusion, our work indicates that down-regulation of KCNQ1OT1 advances cardiac injury through regulating miR +lncRNA target 32102564 hsa-mir-192 Sepsis In conclusion, our work indicates that down-regulation of KCNQ1OT1 advances cardiac injury through regulating miR +genetics_overexpression_promote 32102563 hsa-mir-14 Mouth Neoplasms TIRY overexpression in cancer-associated fibroblasts activated the Wnt/beta-catenin signaling pathway and promoted the invasion and metastasis of OSCC cells through miR-14 sponging based on cancer-associated exosome secretion. +circulation_biomarker_diagnosis_up 32102538 hsa-mir-145 Pancreatic Carcinoma CONCLUSION: The downregulation of serum let +circulation_biomarker_diagnosis_up 32102538 hsa-mir-143 Pancreatic Carcinoma miR-143 and miR-145 expressions were significantly downregulated in the serum of HCC patients than in control group and miR-143 was significantly downregulated in the serum of non-cirrhotic HCV patients than in control group. +circulation_biomarker_diagnosis_up 32102538 hsa-mir-143 Carcinoma, Hepatocellular miR-143 and miR-145 expressions were significantly downregulated in the serum of HCC patients than in control group and miR-143 was significantly downregulated in the serum of non-cirrhotic HCV patients than in control group. +circulation_biomarker_diagnosis_up 32102538 hsa-mir-145 Carcinoma, Hepatocellular CONCLUSION: The downregulation of serum let +circulation_biomarker_diagnosis_ns 32102529 hsa-mir-155 Breast Neoplasms Therefore, circulating miR-155 is potentially applicable as diagnostic therapeutic monitoring marker in breast cancer.
. +other 32102516 hsa-mir-223 Penile Neoplasms 5p is correlated with poor prognosis in penile cancer. +other 32102516 hsa-mir-21 Penile Neoplasms 5p is correlated with poor prognosis in penile cancer. +other 32102516 hsa-mir-107 Penile Neoplasms 5p is correlated with poor prognosis in penile cancer. +lncRNA target 32102467 hsa-mir-34a Lung Neoplasms Quantitative analysis of RNA-seq reads and subsequent validation by qPCR, dual luciferase assay as well as western blotting confirmed that PCP-Seq could highly efficiently identify multiple targets of different miRs in the lung cancer cell line, such as targets PTTG1 and PTGR1 of miR-29a and ILF2 of miR-34a. +lncRNA target 32102467 hsa-mir-29a Lung Neoplasms Quantitative analysis of RNA-seq reads and subsequent validation by qPCR, dual luciferase assay as well as western blotting confirmed that PCP-Seq could highly efficiently identify multiple targets of different miRs in the lung cancer cell line, such as targets PTTG1 and PTGR1 of miR-29a and ILF2 of miR-34a. +genetics_GWAS 32102357 hsa-mir-142 Arrhythmogenic Right Ventricular Dysplasia Six of these were validated in a 90-AC patient cohort independent from genetic status: miR +genetics_GWAS 32102357 hsa-mir-133a Arrhythmogenic Right Ventricular Dysplasia Six of these were validated in a 90-AC patient cohort independent from genetic status: miR +genetics_GWAS 32102357 hsa-mir-122 Arrhythmogenic Right Ventricular Dysplasia Six of these were validated in a 90-AC patient cohort independent from genetic status: miR +genetics_GWAS 32102357 hsa-mir-182 Arrhythmogenic Right Ventricular Dysplasia Six of these were validated in a 90-AC patient cohort independent from genetic status: miR +genetics_GWAS 32102357 hsa-mir-183 Arrhythmogenic Right Ventricular Dysplasia Six of these were validated in a 90-AC patient cohort independent from genetic status: miR +other 32102296 hsa-mir-34a Squamous Cell Carcinoma of Head and Neck In addition, we showed that HIF-1alpha upregulation is associated with the downregulation of miR-34a, increase in CA and expression of cyclin- D1. +lncRNA target 32102121 hsa-let-7g Lung Neoplasms An inhibitor of hsa-let-7g or one targeting a control messenger RNA were transfected into A549 and H1944 lung cancer cells, and the effects of hsa-let-7g dysregulation on cell viability and apoptosis were analyzed using CCK-8 and apoptosis detection assays. +genetics_overexpression_promote 32101951 hsa-mir-10a Neuroblastoma CASC7 overexpression resulted in inhibition, while miR-10a overexpression resulted in increased proliferation rate of neuroblastoma cells. +lncRNA target 32101839 hsa-mir-140 Osteoarthritis 3p could suppress the progression of osteoarthritis by directly targeting CXCR4. +circulation_biomarker_diagnosis_ns 32101583 hsa-mir-126 Cardiovascular Diseases Furthermore, EV-miR126-3p levels in plasma samples from healthy volunteers (n = 18) and high-risk cardiovascular disease (CVD) patients (n = 10) were significantly different (p = 0.006), suggesting EV-miR126 may be a potential biomarker for cardiovascular diseases. +transcription factor target 32101576 hsa-mir-101 Lymphoma In conclusion, the results demonstrated that the four miRNAs comprising miR-101/548b/554/1202 associated with cancer immunity can be a useful prognostic marker in PCNSL and would help us understand target pathways for PCNSL treatments. +transcription factor target 32101576 hsa-mir-548b Lymphoma In conclusion, the results demonstrated that the four miRNAs comprising miR-101/548b/554/1202 associated with cancer immunity can be a useful prognostic marker in PCNSL and would help us understand target pathways for PCNSL treatments. +circulation_biomarker_diagnosis_up 32101049 hsa-mir-423 Diabetic Retinopathy Although six miRNAs were reported in at least two studies and with the consistent direction, after stratification by the type of biological samples, miR-320a was consistently reported to be upregulated in two serum sample-based studies and miR5p was consistently reported to be upregulated in two vitreous humor sample-based studies. +circulation_biomarker_diagnosis_up 32101049 hsa-mir-20a Diabetic Retinopathy Although six miRNAs were reported in at least two studies and with the consistent direction, after stratification by the type of biological samples, miR-320a was consistently reported to be upregulated in two serum sample-based studies and miR5p was consistently reported to be upregulated in two vitreous humor sample-based studies. +lncRNA target 32101017 hsa-mir-214 Nasopharyngeal Carcinoma PTEN and WWOX were knocked down using the corresponding shRNA to investigate their effects on miR-214 inhibitor involved in proapoptosis and antiproliferation mechanisms in NPC. +lncRNA target 32100957 hsa-mir-96 Breast Neoplasms 5p by transfection with its inhibitors in breast cancer cells significantly suppressed miRNA +other 32100921 hsa-mir-139 Breast Neoplasms That is, TTN-AS1 promoted proliferation and invasion of breast cancer cells by interaction with the miR5p/ZEB1 axis. +genetics_GWAS 32100871 hsa-mir-204 Carcinoma, Endometrioid CONCLUSIONS Compared with primary endometrioid endometrial cancer tissue, metastatic loci derived from positive lymph nodes are characterized by profound downregulation of miRNA-204 and miRNA-424. +genetics_GWAS 32100871 hsa-mir-424 Carcinoma, Endometrioid CONCLUSIONS Compared with primary endometrioid endometrial cancer tissue, metastatic loci derived from positive lymph nodes are characterized by profound downregulation of miRNA-204 and miRNA-424. +genetics_knock down_suppress 32100595 hsa-mir-29b Myocardial Reperfusion Injury Next, according to the bioinformatics analysis from miRanda database and a series of gain- and loss-of-function experiments, we proved PEAMIR to be a ceRNA for miR-29b-3p to inhibit cardiac inflammation and apoptosis. +other 32100443 hsa-mir-377 Colonic Neoplasms POU6F2-AS2 promoted cell proliferation and drug resistance in colon cancer by regulating miR-377/BRD4 gene. +genetics_knock down_promote 32100243 hsa-mir-485 Osteosarcoma In conclusion, HSP90 knockdown blocked the phosphorylation of AKT1 suppressing the proliferation and migration capacity of OS cells via the PI3K/AKT pathway; miR5p binds to HSP90 and AKT1 in their 3'-UTR to inhibit HSP90 and AKT1 expression, therefore exerting a tumor suppressor function within osteosarcoma. +lncRNA target 32099901 hsa-mir-17 Inflammation CONCLUSION: Silence of NEAT1 suppressed LPS-induced inflammatory response of macrophages by mediating miR5p and TLR4, indicating that NEAT1 might be a promising target for sepsis treatment. +transcription factor target 32099552 hsa-mir-15 Viral Myocarditis CONCLUSION: Our results indicate that miR-15 inhibition alleviates CVB3-induced myocardial inflammation and cell injury. +transcription factor target 32099552 hsa-mir-15 Cardiomyopathies CONCLUSION: Our results indicate that miR-15 inhibition alleviates CVB3-induced myocardial inflammation and cell injury. +lncRNA target 32099534 hsa-mir-641 Osteoarthritis CONCLUSION: Overall, our results indicate that circRNA-CDR1as plays a crucial role in regulating OA progression via modulating extracellular matrix metabolism and inflammation via sponging miR-641 and provide a novel regulatory role of circRNA-CDR1as in OA. +lncRNA target 32099530 hsa-mir-223 Stomach Neoplasms 3p and increasing NDRG1 in GC, indicating a novel target for treatment of GC. +other 32099529 hsa-mir-200 Colorectal Neoplasms CONCLUSIONS: Current evidences revealed that miR-200s could be promising biomarkers for CRC prognosis. +other 32099529 hsa-mir-200a Colorectal Neoplasms CONCLUSIONS: Current evidences revealed that miR-200s could be promising biomarkers for CRC prognosis. +lncRNA target 32099527 hsa-mir-7 Colorectal Neoplasms 5p, suggesting that RHPN1-AS1 might be a potential therapeutic target for CRC. +genetics_knock down_promote 32099526 hsa-mir-135a Glioma CONCLUSION: DANCR knockdown inhibited cell proliferation, migration and invasion in glioma cells through regulating miR-135a-5p/BMI1 axis, providing viable therapeutic avenues for treatment of glioma. +lncRNA target 32099465 hsa-mir-1285 Ovarian Neoplasms Rescue assay validated that miR3p inhibitors abrogated LEF1-AS1-silencer-caused suppression of ovarian cancer progression. +other 32099409 hsa-mir-190a Glioma CONCLUSION: Taken together, the current study revealed a PART1/miR-190a-3p/PTEN/PI3K/AKT axis in glioma and provided novel insights for understanding the complex lncRNA-miRNA network in glioma. +other 32099409 hsa-mir-190 Glioma CONCLUSION: Taken together, the current study revealed a PART1/miR-190a-3p/PTEN/PI3K/AKT axis in glioma and provided novel insights for understanding the complex lncRNA-miRNA network in glioma. +genetics_overexpression_promote 32099406 hsa-mir-873 Thyroid Cancer, Papillary 5p inhibited PTC cell proliferation, migration and invasion, while co-transfection of CXCL16 overexpression plasmid reversed the anti-tumor behaviors induced by miR +lncRNA target 32099403 hsa-mir-155 Stomach Neoplasms CONCLUSION: Our findings indicated that over-expression of circ_0006282 downregulated miR-155 to activate the expression of FBXO22, thus promoting proliferation and metastasis of GC cells, which provides a promising therapeutic target for GC treatment. +lncRNA target 32099401 hsa-mir-885 Carcinoma, Hepatocellular 5p may be a potential biomarker and can be targeted in therapeutic strategies against HCC in the future. +lncRNA target 32099397 hsa-mir-195 Uterine Cervical Neoplasms 5p mimics or inhibitor. +lncRNA target 32099396 hsa-mir-944 Carcinoma, Non-Small-Cell Lung CONCLUSION: Our study illustrates that SNHG6 is an oncogene in NSCLC and involved in NSCLC tumorigenesis by regulating ETS1 signaling via miR-944 and miR-181d-5p. +transcription factor target 32099392 hsa-mir-1 Liver Neoplasms miR-31 is downregulated in liver cancer and associated with tumor growth and metastasis. RESULTS: In the present study, our results confirm that miR-31 promotes apoptosis and inhibits proliferation and metastasis in liver cancer HepG2 cells. +transcription factor target 32099369 hsa-mir-182 Epilepsy CONCLUSION: APLN could protect the neurons from injury in epilepsy by regulating the expression of apoptosis-associated proteins and mGluR1 and increasing p-AKT levels, which were attenuated by miR-182. Hence, miR-182/APLN may be potential targets for epilepsy control and treatment. +exosome 32099009 hsa-mir-29c Kidney Diseases In conclusion, the linagliptin and telmisartan-induced restorative effects on miR-29c expression were reflected in urinary exosomes, suggesting that miRNA profiling of urinary exosomes might be used as a biomarker for CKD progression and monitoring of treatment effects. +genetics_knock down_promote 32098924 hsa-mir-454 Triple Negative Breast Neoplasms Moreover, miR-454 was predicted and confirmed to be a target of XIST, and rescue assay indicated that overexpressed miR-454 could reverse XIST restoration mediated-anti-tumor effects on TNBC cells. +lncRNA target 32098916 hsa-mir-143 Hypertension, Pulmonary This paper explores the potential mechanism of microRNA5p regulation effects on pulmonary artery smooth muscle cells (PASMCs) functions in hypoxic pulmonary hypertension (HPH) via targeting HIF-1a, which may offer a new idea for HPH therapy. +transcription factor target 32098914 hsa-mir-20b Cardiovascular Diseases In conclusion, our results indicate that propofol inhibits autophagic cell death via the miR-20b-5p-ULKI axis and that ULK1 may be a therapeutic target for cardiovascular IR injury. +genetics_knock down_promote 32098696 hsa-mir-20a Thyroid Cancer, Papillary Overexpressing miR-320a promoted malignant behaviors of TPC-1 cells. +epigenetics 32098627 hsa-mir-181a Glioblastoma Our study also reveals that cytosine-methylation of miRNA-181a-5p results is associated a poor prognosis in GBM patients. +circulation_biomarker_diagnosis_ns 32098619 hsa-mir-193b Subarachnoid Hemorrhage The effects of miR-193b-3p on SAH were assayed using a neurological score, brain water content, blood-brain barrier (BBB) injury, and Fluoro-Jade C (FJC) staining. +circulation_biomarker_diagnosis_ns 32098619 hsa-mir-193b Brain Injuries The effects of miR-193b-3p on SAH were assayed using a neurological score, brain water content, blood-brain barrier (BBB) injury, and Fluoro-Jade C (FJC) staining. +lncRNA target 32098588 hsa-mir-384 Neuralgia 5p might be a promising therapeutic target in the treatment of neuropathic pain.Abbreviations: CCI: Chronic constriction injury; ZEB1: Zinc finger E box binding protein-1; MAPK6: Mitogen-activated protein kinase 6; COX-2: cyclooxygenase-2. +transcription factor target 32098295 hsa-mir-210 Glioblastoma The PAD3 inhibitor was most effective in modulating EVs to anti-oncogenic signatures (reduced miR21 and miR210, and elevated miR126), to reduce cell invasion and to modulate protein expression of pro-GBM proteins in LN229 cells, while the PAD2 and PAD4 inhibitors were more effective in LN18 cells. +transcription factor target 32098295 hsa-mir-21 Glioblastoma The PAD3 inhibitor was most effective in modulating EVs to anti-oncogenic signatures (reduced miR21 and miR210, and elevated miR126), to reduce cell invasion and to modulate protein expression of pro-GBM proteins in LN229 cells, while the PAD2 and PAD4 inhibitors were more effective in LN18 cells. +transcription factor target 32098295 hsa-mir-126 Glioblastoma The PAD3 inhibitor was most effective in modulating EVs to anti-oncogenic signatures (reduced miR21 and miR210, and elevated miR126), to reduce cell invasion and to modulate protein expression of pro-GBM proteins in LN229 cells, while the PAD2 and PAD4 inhibitors were more effective in LN18 cells. +exosome 32098213 hsa-mir-219a Encephalomyelitis, Autoimmune, Experimental Our results indicate that the use of extracellular vesicles as miR-219a-5p delivery system can be a feasible and promising strategy to induce remyelination in multiple sclerosis patients. +genetics_overexpression_promote 32096481 hsa-mir-134 Carcinoma, Non-Small-Cell Lung Forced overexpression of miR-134 mimicked circNT5E shRNA-induced actions, inhibiting NSCLC cell growth and proliferation. +exosome 32096479 hsa-mir-342 Atherosclerosis 5p mediated by ADSCs-derived exosomes protects endothelial cells against atherosclerosis. +lncRNA target 32096299 hsa-mir-155 Triple Negative Breast Neoplasms These data provide a therapeutic strategy and mechanistic basis for future possible clinical applications targeting the miR-155/TSPAN5 signaling axis in the treatment of TNBC. +lncRNA target 32096191 hsa-mir-34a Spinal Cord Injuries OBJECTIVE: The purpose of this study was to investigate role of inhibition of microRNA-34a (miR-34a) in neural damage and repair after spinal cord injury, and to explore the underlying mechanism. +genetics_knock down_promote 32096190 hsa-mir-155 Reperfusion Injury, Cerebral Ischemia 5p knockdown inhibited OGD/R-induced cell injury and inflammation, as well as MCAO/R-induced brain injury. +genetics_knock down_promote 32096186 hsa-mir-19a Cardiomegaly Furthermore, both microRNA-19a-3p overexpression or SMYD2 knockdown could inhibit and reduce the cardiomyocyte surface area, and downregulate the levels of the cardiac hypertrophic markers. +lncRNA target 32096185 hsa-mir-150 Myocardial Infarction, Acute CONCLUSIONS: XIST protects cardiomyocytes from hypoxia-induced injury by mediating miR5p/Bax axis, suggesting that XIST is an important target for AMI treatment. +lncRNA target 32096181 hsa-mir-137 Osteoporosis The osteoporosis model in rats was prepared in the model group, and miR-137 inhibitor was administered in osteoporosis rats of inhibitor group. CONCLUSIONS: MiR-137 regulates RUNX2 to affect the bone mineral density of osteoporosis model rats. +lncRNA target 32096180 hsa-mir-16 Chordoma CONCLUSIONS: LINC00662 participated in the malignant progression of chordoma by the promotion of RNF144B by acting as a sponge of miR5p, suggesting that LINC00662 was a promising therapeutic target for chordoma. +lncRNA target 32096178 hsa-mir-424 Wilms Tumor In addition, CRNDE might accelerate the progression of Wilms' tumor via modulating microRNA-424. +lncRNA target 32096176 hsa-mir-584 Ovarian Neoplasms By negatively regulating LPIN1, miRNA-584 suppresses the malignant progression of OCa. +lncRNA target 32096172 hsa-mir-19 Pancreatic Carcinoma Here, we decided to investigate the miR-19 effect and molecular mechanism on pancreatic cancer, which was blank until now. CONCLUSIONS: We demonstrated that miR-19 facilitated cell progression through modulating PI3K/AKT signaling pathway by targeting PTEN, which provided a potential therapeutic target for pancreatic cancer patients. +transcription factor target 32096168 hsa-mir-875 Colorectal Neoplasms 3p alleviates the progression of CRC through targeting and downregulating PLK1. +lncRNA target 32096167 hsa-mir-135b Melanoma CONCLUSIONS: MiR-135b inhibited the progression of MM by targeting RBX1. +genetics_overexpression_promote 32096165 hsa-mir-625 Stomach Neoplasms 3p overexpression and down-regulation models in vitro, respectively. +lncRNA target 32096156 hsa-mir-221 Laryngeal Neoplasms CONCLUSIONS: MiR-221 analogues can significantly inhibit the proliferation and induce apoptosis of Hep-2 cells in laryngeal cancer, and this is achieved by blocking the PI3K/AKT signaling pathway, which also indicates that MiR-221 affects the proliferation and apoptosis of laryngeal cancer cells through the PI3K/AKT signaling pathway. +genetics_overexpression_promote 32096149 hsa-mir-429 Esophageal Squamous Cell Carcinoma In addition, overexpression of miR-429 suppressed tumor growth of ESCC in vivo. +lncRNA target 32096148 hsa-mir-26a Stomach Neoplasms CONCLUSIONS: Collectively, miR-26a-5p can potentiate proliferation, migration, and invasion of gastric cancer cells by targeting COL10A1. +transcription factor target 32095982 hsa-mir-17 Spinal Cord Injuries Therefore, miR5p/STAT3/GAP-43 pathway plays a key role in regulating cortical neuron axon growth and could be a novel target to treat SCI. +genetics_knock down_promote 32095930 hsa-mir-519d Ovarian Neoplasms We also found that miR-519d-3p overexpression could inhibit ovarian cancer cells proliferation, migration and invasion. Taken together, BLACAT1 knockdown inhibited the progression of ovarian cancer by suppressing the Wnt/beta-catenin signaling pathway via regulating miR-519d-3p. +lncRNA target 32095352 hsa-mir-1247 isolated cleft palate 3p and its cognate target genes suggested their great potential as novel therapeutic targets or diagnostic biomarkers of CPV or other related viruses. +other 32095352 hsa-mir-22 isolated cleft palate 3p) and three novel miRNAs (Novel 137, Novel 141 and Novel 102) by sRNA-seq with differentially expressed genes in the miRNA repertoire of CPV-infected cells over control. +other 32095352 hsa-mir-361 isolated cleft palate 3p) and three novel miRNAs (Novel 137, Novel 141 and Novel 102) by sRNA-seq with differentially expressed genes in the miRNA repertoire of CPV-infected cells over control. +other 32095352 hsa-mir-222 isolated cleft palate 3p) and three novel miRNAs (Novel 137, Novel 141 and Novel 102) by sRNA-seq with differentially expressed genes in the miRNA repertoire of CPV-infected cells over control. +other 32095352 hsa-mir-365-2 isolated cleft palate 3p) and three novel miRNAs (Novel 137, Novel 141 and Novel 102) by sRNA-seq with differentially expressed genes in the miRNA repertoire of CPV-infected cells over control. +lncRNA target 32095323 hsa-mir-193a Carcinoma, Hepatocellular CONCLUSION: miR-193a-3p could suppress proliferation and promote apoptosis by targeting CCND1 in HCC cells. +genetics_overexpression_promote 32095078 hsa-mir-214 Retinoblastoma Overexpression of miR +other 32094435 hsa-mir-34a Stroke Our study provides the first description of miR-34a affecting stroke outcomes and may lead to discovery of new mechanisms and treatments for cerebrovascular and neurodegenerative diseases such as stroke. +transcription factor target 32094409 hsa-mir-451a Brain Injuries, Traumatic Chronically dysregulated miRNAs (miR-451a, miR-30d-5p, miR +transcription factor target 32094409 hsa-mir-145 Brain Injuries, Traumatic Chronically dysregulated miRNAs (miR-451a, miR-30d-5p, miR +transcription factor target 32094378 hsa-mir-23b Uterine Cervical Neoplasms Although, it has been proposed that miR-23b-3p acts as a tumor suppressor in cervical cancer (CC), not all the pathways through which it alters the cellular processes have been described. Together, the results in the present study indicate that miR-23b-3p is a tumor suppressor that modulates the progression of CC via post-transcriptional regulation of the c-Met oncogene. +circRNA target 32094325 hsa-mir-487a Breast Neoplasms In conclusion, this finding illustrates the vital roles of circRNF20 via the circRNF20/ miR-487a/HIF-1alpha/HK2 axis in breast cancer progress and Warburg effect, providing an interesting insight for the BC tumorigenesis. +genetics_overexpression_promote 32094308 hsa-mir-5000 Laryngeal Neoplasms 3p upregulation countervailed the repressive effects of MIR22HG overexpression on laryngocarcinoma progression. +lncRNA target 32094299 hsa-mir-486 Glioblastoma 5p-dependent modulation of tumor suppressor genes that feeds back to regulate glioma stem cell survival. +exosome 32093888 hsa-mir-17 Cholesteatoma, Middle Ear In conclusions, we provide evidence that exosomes miRNA-17 secreted by keratinocytes in patients with middle ear cholesteatoma can up-regulate the expression of RANKL in fibroblasts and induce osteoclast differentiation. +genetics_overexpression_promote 32093712 hsa-mir-214 Obesity According to the measurement of glucose and insulin tolerance and glucose uptake abilities, we found that the overexpression of miR-214 could be used to alleviate IR in the IR models, especially when collaboratively used with DPP4 inhibitor vildagliptin. +transcription factor target 32093694 hsa-mir-143 Acquired Immunodeficiency Syndrome 3p with potential to intervene disease progression, which provides a new strategy for developing targeted therapies. +genetics_knock down_suppress 32093419 hsa-mir-23a Leukemia, Myeloid, Acute Initially, we assessed AraC sensitivity in three AML cell lines following miR-23a overexpression/knockdown using MTT-cell viability and soft-agar colony-formation assays. +other 32093260 hsa-mir-205 esophagus adenocarcinoma In addition, the anti-EMT microRNA-205 was significantly more expressed in ESD-resected samples, whereas we found no significant differences in the expression levels of microRNA-200 family members. Furthermore, in our retrospective approach, we have demonstrated that measurement of selected EMT markers and microRNA-205 has significant discrimination power to distinguish ESD-resected and surgically resected samples. +other 32093169 hsa-mir-181a Pre-Eclampsia The possibility of detecting early PE according to the logistic regression model (miR-92b-3p, miR-125b-5p, and miR-181a-5p (AUC = 0.91)) was evaluated. +other 32093169 hsa-mir-125b Pre-Eclampsia The possibility of detecting early PE according to the logistic regression model (miR-92b-3p, miR-125b-5p, and miR-181a-5p (AUC = 0.91)) was evaluated. +circulation_biomarker_diagnosis_ns 32093169 hsa-mir-27b Pre-Eclampsia The expression of miR-27b-3p, miR-92b-3p, miR-125b-5p, miR-181a-5p, and miR5p, as regulated by hypoxia/reoxygenation, was significantly increased in blood plasma during early-onset preeclampsia. +other 32093169 hsa-mir-92b Pre-Eclampsia The possibility of detecting early PE according to the logistic regression model (miR-92b-3p, miR-125b-5p, and miR-181a-5p (AUC = 0.91)) was evaluated. +other 32092939 hsa-mir-21 Renal Allograft Dysfunction miR-21 is associated with renal allograft dysfunction and IFTA. +lncRNA target 32092829 hsa-mir-153 Colorectal Neoplasms In conclusion, this study identifies the roles of LINC00511 in CRC progression and uncovers the positive feedback loop of HIF-1alpha/LINC00511/miR5p in CRC, providing a potential therapeutic target. +genetics_overexpression_promote 32092824 hsa-mir-101a Kidney Failure, Chronic Besides, overexpressed YAP/TGF-beta2 or inhibited TGIF1 partially restored the inhibitory effect of miR-101a on chronic renal fibrosis. +lncRNA target 32092823 hsa-mir-135a Carcinoma, Non-Small-Cell Lung Subcutaneous xenotransplanted tumor model was set up and it was confirmed increased MBNL1-AS1 remarkably restrained tumorigenic ability of NSCLC through sponging miR-135a-5p in vivo. +genetics_knock down_promote 32092817 hsa-mir-361 Breast Neoplasms The knockdown of E2F1 by siRNA promoted breast cancer cell proliferation and inhibited apoptosis, similar to miR +other 32092815 hsa-mir-425 Cardiotoxicity Furthermore, activation of miR-425 by IR markedly improved DOX-induced cardiotoxicity, and therefore IR could be considered as a promising therapeutic agent for the treatment of cardiac injury. +transcription factor target 32092796 hsa-mir-34c Alzheimer Disease These results indicated that increased miR-34c mediated synaptic and memory deficits by targeting SYT1 through ROS-JNK-p53 pathway and the miR-34c/SYT1 pathway could be considered as a promising novel therapeutic target for patients with AD. +genetics_overexpression_promote 32092782 hsa-mir-200b Colorectal Neoplasms However, the overexpression of TUBB3 reversed miR-200b-3p mimic-induced migration, as well as growth inhibition and apoptosis, in L-OHP resistant CRC cells. +transcription factor target 32092754 hsa-mir-422a Colorectal Neoplasms We then used vector construction and dual-luciferase reporter assays to investigate the targeting relationship of DCC rs12607853 with hsa-miR-422a and hsa-miR-378c. +genetics_GWAS 32092393 hsa-mir-499 Coronary Artery Disease CONCLUSIONS: Our results suggest that at least two of the studied polymorphisms, miR196a2 C>T (rs11614913) and miR499 A>G (rs3746444), as well as the miR146C-miR149C-miR196T-miR499G allele combination could represent useful biomarkers of CAD and/or MI susceptibility in the Greek population. +other 32092330 hsa-mir-374a Osteoarthritis RESULTS: The data set showed that miR-374a-3p was decreased in OA cartilages and the consistent expressional pattern was observed in LPS-stimulated CHON-001 cells. +other 32092085 hsa-mir-141 Carcinoma, Non-Small-Cell Lung MiR3p expression was negatively related to lncRNA-ATB expression in NSCLC tissues. +circulation_biomarker_diagnosis_ns 32092075 hsa-mir-26a Diabetes Mellitus, Type 2 MiR-26a is reduced in serum exosomes of overweight humans and is inversely correlated with clinical features of T2D. +other 32091667 hsa-mir-21 Adenocarcinoma of Lung METHODS: The Cancer Genome Atlas dataset comprising of 448 cases of lung adenocarcinoma, tissue microarray of 144 cases of lung adenocarcinoma, and pleural lavage fluid of 41 cases was used to examine miR-21 expression levels. RESULTS: The miR-21 expression level in primary sites was associated with a poor prognosis and correlated with pleural invasion of adenocarcinoma. +transcription factor target 32091625 hsa-mir-192 Stomach Neoplasms In summary, miRNA-192 and -215 target APC and function as oncogenic miRNAs by activating Wnt signaling in GC, revealing to be potential therapeutic targets. +other 32091151 hsa-mir-382 Hemangioma, Cavernous 5p/VEGFA axis. +genetics_overexpression_promote 32090685 hsa-mir-185 Intervertebral Disc Degeneration CONCLUSIONS: Overexpression of miR-185 promotes nucleus pulposus cell viability and reduces the histological changes observed in intervertebral disc tissues in rats with intervertebral disc degeneration via inactivation of the Wnt/beta-catenin signaling pathway and Galectin-3 inhibition. +transcription factor target 32090639 hsa-mir-128 Colorectal Neoplasms Underlying mechanisms study revealed that the miR3p inhibited the growth, migration, and invasion of colorectal cancer (CRC) cells and progress of CRC tissues through silence of the activity of PI3K/AKT and MEK/ERK pathway. +genetics_overexpression_promote 32090627 hsa-mir-146a Cerebral Hemorrhage The overexpression of miR-146a inhibited the autophagy of hippocampal neurons in rats with ICH. +tissue_expression_ns 32090604 hsa-let-7e Anemia, Neonatal The deficiency of E-cadherin is caused by destabilization of its mRNA precursor because of increased expression and binding of another molecule, the microRNA let-7e-5p, to the E-cadherin mRNA. +other 32090545 hsa-mir-141 Prostatic Neoplasms We also show that this system can detect miR-141 in only 50 ng of total RNA samples from real cells, which allows discrimination of prostate cancer cells with normal cells. +other 32090516 hsa-mir-122 Obesity Furthermore, assessment of miR5p could be an indicator of an adverse metabolic health status independent of obesity. +genetics_knock down_promote 32090490 hsa-mir-21 Melanoma 5p significantly enhanced, whereas knockdown attenuated, cell proliferation and G1/S transition in melanoma cell lines (A375 and M14). +circulation_biomarker_diagnosis_up 32090367 hsa-mir-574 Acute Lung Injury Up-regulation of miR-574 attenuated sepsis-induced lung injury may be by promoting C3 down-regulation and reducing sepsis-induced endoplasmic reticulum stress (ERS). In this study, up-regulation of miR-574 attenuated sepsis-induced lung injury may be by promoting C3 down-regulation and reducing sepsis-induced ERS. +circulation_biomarker_diagnosis_up 32090367 hsa-mir-574 Sepsis Up-regulation of miR-574 attenuated sepsis-induced lung injury may be by promoting C3 down-regulation and reducing sepsis-induced endoplasmic reticulum stress (ERS). In this study, up-regulation of miR-574 attenuated sepsis-induced lung injury may be by promoting C3 down-regulation and reducing sepsis-induced ERS. +genetics_knock down_promote 32090104 hsa-mir-155 Brain Ischemia CONCLUSION: Our results suggest that miR-155 knockdown alleviated ischemia-reperfusion injury by targeting MafB to improve the neurological function and inhibit inflammation response, highlighting a novel therapeutic strategist for CIRI. +other 32090093 hsa-mir-221 Atherosclerosis DESIGN: The aim of this research was to explore the role of L-arginine in the development of AS and the mechanisms by which miR-221 influences the possible signaling pathways in endothelial cells during AS. +lncRNA target 32090087 hsa-mir-326 Stomach Neoplasms In conclusion, hsa_circ_0000467 plays a regulatory role in the development and progression of gastric cancer by regulating miR3p, and this circRNA may be a potential diagnostic marker and therapeutic target of gastric cancer. +other 32090086 hsa-mir-200a Colonic Neoplasms 5p and miR-200a-3p) were recognized to be hub miRNAs associated with the progression of colon cancer. +other 32090086 hsa-mir-182 Colonic Neoplasms 5p and miR-200a-3p) were recognized to be hub miRNAs associated with the progression of colon cancer. +other 32090086 hsa-mir-17 Colonic Neoplasms 5p and miR-200a-3p) were recognized to be hub miRNAs associated with the progression of colon cancer. +genetics_overexpression_promote 32089626 hsa-mir-34c Stomach Neoplasms RESULTS: E2F1 was overexpressed while miR-34c was underexpressed in GC. +genetics_overexpression_promote 32089501 hsa-mir-188 Carcinoma, Hepatocellular In addition, overexpression of miR +circulation_biomarker_prognosis_ns 32089410 hsa-mir-34a Hepatitis, Chronic Serum TBA, AST and ALT levels, and AST/ALT ratios in patients with CHC were increased with increasing degree of fibrosis, and were positively associated with serum miR-34a. +circulation_biomarker_prognosis_ns 32089410 hsa-mir-34a Liver Cirrhosis Serum TBA, AST and ALT levels, and AST/ALT ratios in patients with CHC were increased with increasing degree of fibrosis, and were positively associated with serum miR-34a. +transcription factor target 32089065 hsa-mir-182 Neuralgia We also found that miR-182 expression inhibition erased the analgesia effect of resveratrol to CCI-induced neuropathic pain possibly through upregulating Nav1.7 expression. In summary, resveratrol alleviated CCI-induced neuropathic pain, possibly through activating Sirt1 to suppress Nav1.7 expression via upregulating miR-182 expression in CCI DRGs. +genetics_knock down_promote 32089063 hsa-mir-876 Squamous Cell Carcinoma of Head and Neck MiR-876 downregulation strongly attenuated the actions of the SNHG17 knockdown in TSCC cells. +lncRNA target 32089062 hsa-mir-24 Prostatic Neoplasms 3p and FSCN1, indicating a novel avenue for treatment of PCa through regulating chemoresistance. +circulation_biomarker_prognosis_down 32088997 hsa-mir-22 Carcinoma, Hepatocellular Receiver operating characteristic (ROC) curve was built to estimate the diagnostic value of serum miR-22 in HCC.Results: miR-22 expression was significantly down-regulated in HCC compared to that in healthy controls (p < .05). +lncRNA target 32088872 hsa-mir-145 Cystic Fibrosis The aim of the present article is to describe methods for determining the activity of PNAs designed to target microRNAs involved in cystic fibrosis, using as model system miR5p and its target cystic fibrosis transmembrane conductance regulator (CFTR) mRNA. +lncRNA target 32088641 hsa-mir-145 Arthritis, Rheumatoid 5p regulates the survival/proliferation of FLS cells in RA disease condition through attenuation of Wnt1/beta-catenin signaling. +exosome 32088640 hsa-mir-26a Depression CONCLUSION: Collectively, our study reveals that miR-26a is lowly expressed in depressed rats, and BMSCs-derived exosomes improve hippocampal neuron injury of rat with depression by upregulating miR-26a. +genetics_GWAS 32088305 hsa-mir-335 Dermatitis, Atopic We demonstrate that miR-335 is epigenetically regulated by histone deacetylases; a screen for suitable histone deacetylase inhibitors identified belinostat as a candidate drug that can restore epidermal miR-335 expression and rescue the defective skin barrier in AD. +other 32087738 hsa-mir-506 Neuroblastoma 3p is an important mechanism in regulating neuroblastoma cell fate, determining neuroblastoma prognosis, and mediating the therapeutic function of retinoic acid. +lncRNA target 32087725 hsa-mir-34b Acute Lung Injury CONCLUSION: TUG1 alleviated sepsis-induced inflammation and apoptosis via targeting miR-34b-5p and GAB1. +lncRNA target 32087725 hsa-mir-34b Sepsis CONCLUSION: TUG1 alleviated sepsis-induced inflammation and apoptosis via targeting miR-34b-5p and GAB1. +circulation_biomarker_diagnosis_ns 32087719 hsa-mir-192 Inflammatory Bowel Diseases RESULTS: Compared to healthy control dogs, dogs with large intestinal IBD showed significantly increased relative expression of miR-16, miR-21, miR-122 and miR-147 in the colonic mucosa and serum, while the relative expression of miR-185, miR-192 and miR-223 was significantly decreased. +circulation_biomarker_diagnosis_ns 32087719 hsa-mir-122 Inflammatory Bowel Diseases RESULTS: Compared to healthy control dogs, dogs with large intestinal IBD showed significantly increased relative expression of miR-16, miR-21, miR-122 and miR-147 in the colonic mucosa and serum, while the relative expression of miR-185, miR-192 and miR-223 was significantly decreased. +circulation_biomarker_diagnosis_ns 32087719 hsa-mir-21 Inflammatory Bowel Diseases RESULTS: Compared to healthy control dogs, dogs with large intestinal IBD showed significantly increased relative expression of miR-16, miR-21, miR-122 and miR-147 in the colonic mucosa and serum, while the relative expression of miR-185, miR-192 and miR-223 was significantly decreased. +circulation_biomarker_diagnosis_ns 32087719 hsa-mir-185 Inflammatory Bowel Diseases RESULTS: Compared to healthy control dogs, dogs with large intestinal IBD showed significantly increased relative expression of miR-16, miR-21, miR-122 and miR-147 in the colonic mucosa and serum, while the relative expression of miR-185, miR-192 and miR-223 was significantly decreased. +circulation_biomarker_diagnosis_ns 32087719 hsa-mir-147 Inflammatory Bowel Diseases RESULTS: Compared to healthy control dogs, dogs with large intestinal IBD showed significantly increased relative expression of miR-16, miR-21, miR-122 and miR-147 in the colonic mucosa and serum, while the relative expression of miR-185, miR-192 and miR-223 was significantly decreased. +circulation_biomarker_diagnosis_ns 32087719 hsa-mir-16 Inflammatory Bowel Diseases RESULTS: Compared to healthy control dogs, dogs with large intestinal IBD showed significantly increased relative expression of miR-16, miR-21, miR-122 and miR-147 in the colonic mucosa and serum, while the relative expression of miR-185, miR-192 and miR-223 was significantly decreased. +circulation_biomarker_diagnosis_ns 32087719 hsa-mir-223 Inflammatory Bowel Diseases RESULTS: Compared to healthy control dogs, dogs with large intestinal IBD showed significantly increased relative expression of miR-16, miR-21, miR-122 and miR-147 in the colonic mucosa and serum, while the relative expression of miR-185, miR-192 and miR-223 was significantly decreased. +lncRNA target 32087604 hsa-mir-210 Uterine Cervical Neoplasms In conclusion, we demonstrated that MIR210HG promoted CC progression through regulating the MIR210HG/miR +circRNA target 32087327 hsa-mir-1305 Osteoporosis In this study, we described a previously found circular RNA, circ_0076906, to bind miR-1305 and regulate its target gene, Osteoglycin (OGN), thus regulate osteogenic differentiation of hMSCs and alleviate the progression of osteoporosis. Circ_0076906 relieved osteoporosis and promoted osteogenic differentiation through the miR-1305/ OGN pathway. +exosome 32087271 hsa-mir-4435-1 Arteriovenous Malformations qRT-PCR demonstrated that the exosomal lncRNAs MIR4435-1HG, LINC00657, LOC101927854 and SEPT5-GP1BB were upregulated in AVM exosomes. +genetics_knock down_promote 32087217 hsa-mir-148a Myocardial Reperfusion Injury Gain- and loss- of function studies of miR-148a and TXNIP were performed to figure out their roles in MI/R injury. +other 32087087 hsa-mir-26a-2 Scleroderma, Systemic This implies that reduced expression of miRNA-26a3 may be involved in pathogenic IFN signature in SSc monocytes. +transcription factor target 32087004 hsa-mir-181a Alzheimer Disease Lastly, we observed that inhibition of miR-181a alleviated memory deficits and increased GluA2 and GluA1 levels, without restoring translin, in the 3xTg-AD model. +genetics_overexpression_promote 32086979 hsa-mir-361 Squamous Cell Carcinoma of Head and Neck 3p is overexpressed in OSCC tissues. +genetics_overexpression_promote 32086919 hsa-mir-340 Laryngeal Neoplasms 5p was significantly increased or decreased after overexpression or inhibition; Luciferase activity showed that miR +other 32086782 hsa-mir-195 Esophageal Squamous Cell Carcinoma 5p/BCL9 network is proposed to be the mechanism leading to ESCC progression. +transcription factor target 32086739 hsa-mir-486 Glioblastoma 3p may be a potential target for glioblastoma treatment to improve the curative effects. +other 32086547 hsa-mir-93 Acute Kidney Injury A set of microRNAs (miR-20a, miR-92a, miR-93, miR-195, miR-451) could be promising biomarkers for early detection of oxalic acid-induced acute kidney injury. +other 32086547 hsa-mir-195 Acute Kidney Injury A set of microRNAs (miR-20a, miR-92a, miR-93, miR-195, miR-451) could be promising biomarkers for early detection of oxalic acid-induced acute kidney injury. +other 32086547 hsa-mir-451 Acute Kidney Injury A set of microRNAs (miR-20a, miR-92a, miR-93, miR-195, miR-451) could be promising biomarkers for early detection of oxalic acid-induced acute kidney injury. +other 32086547 hsa-mir-92a Acute Kidney Injury A set of microRNAs (miR-20a, miR-92a, miR-93, miR-195, miR-451) could be promising biomarkers for early detection of oxalic acid-induced acute kidney injury. +other 32086547 hsa-mir-20a Acute Kidney Injury A set of microRNAs (miR-20a, miR-92a, miR-93, miR-195, miR-451) could be promising biomarkers for early detection of oxalic acid-induced acute kidney injury. +lncRNA target 32085895 hsa-mir-204 Glaucoma LINC00028 regulated proliferation, migration, invasion, EMT, fibrosis and autophagy to induce the development of HTFs by competitively targeting miR5p, and LINC00028 was regarded as a promising biomarker for glaucoma filtration treatment. +lncRNA target 32085895 hsa-mir-204 Fibrosis LINC00028 regulated proliferation, migration, invasion, EMT, fibrosis and autophagy to induce the development of HTFs by competitively targeting miR5p, and LINC00028 was regarded as a promising biomarker for glaucoma filtration treatment. +lncRNA target 32085745 hsa-mir-17 Breast Neoplasms 92 cluster of microRNAs and suppression of several known miR +lncRNA target 32085745 hsa-mir-17 Triple Negative Breast Neoplasms 92 cluster of microRNAs and suppression of several known miR +exosome 32085620 hsa-mir-135b Lupus Nephritis Urinary exosomal miR-135b-5p, miR-107, and miR-31 are promising novel markers for clinical outcomes, regulating LN renal recovery by HIF1A inhibition. +exosome 32085620 hsa-mir-107 Lupus Nephritis Urinary exosomal miR-135b-5p, miR-107, and miR-31 are promising novel markers for clinical outcomes, regulating LN renal recovery by HIF1A inhibition. +exosome 32085620 hsa-mir-1 Lupus Nephritis Urinary exosomal miR-135b-5p, miR-107, and miR-31 are promising novel markers for clinical outcomes, regulating LN renal recovery by HIF1A inhibition. +other 32084702 hsa-mir-218 Carcinoma, Non-Small-Cell Lung Furthermore, bioinformatics online program predictions and luciferase reporter assay were used to validate the association of CCAT1 and miR-218 in NSCLC cells. +lncRNA target 32084582 hsa-mir-206 Hemangioma RESULTS: The results showed that MALAT1 and VEGFA were high-expressed and miR-206 was low-expressed in IH tissues. CONCLUSION: Knock-down of MALAT1 inhibits the growth of HemECs through regulating miR-206/VEGFA axis, indicating that MALAT1 is a potential therapeutic mechanism for the treatment of IH. +transcription factor target 32084559 hsa-mir-27a Reperfusion Injury, Renal Ischemia Our data showed that miR-27a-3p aggravated RI/R injury by promoting oxidative stress via targeting Grb2, which should be considered as one new drug target to treat RI/R injury. +other 32084395 hsa-mir-29a Cardiomyopathies CONCLUSIONS: Our findings suggested that ghrelin protected against obesity-induced myocardial injury by regulating the H19/miR-29a/IGF-1 signalling axis, providing further evidence for the clinical application of ghrelin. +other 32084395 hsa-mir-29a Obesity CONCLUSIONS: Our findings suggested that ghrelin protected against obesity-induced myocardial injury by regulating the H19/miR-29a/IGF-1 signalling axis, providing further evidence for the clinical application of ghrelin. +genetics_knock down_promote 32084370 hsa-mir-18a Bronchopulmonary Dysplasia In conclusion, knockdown of MEG3 inhibits pyroptosis to alleviate hyperoxia lung injury by suppressing NLRP3 inflammasome and caspase-1 signaling via regulating miR-18a-TXNIP axis. +genetics_knock down_promote 32084370 hsa-mir-18a Lung Injury In conclusion, knockdown of MEG3 inhibits pyroptosis to alleviate hyperoxia lung injury by suppressing NLRP3 inflammasome and caspase-1 signaling via regulating miR-18a-TXNIP axis. +circulation_biomarker_diagnosis_ns 32083575 hsa-mir-518b Breast Neoplasms Among these, miR-518b, -4719 and 3p were found specifically deregulated in BC serum. +other 32083569 hsa-mir-20b Nasopharyngeal Carcinoma Moreover, a five-miRNA profile (miR-106b, miR-17, miR-20b, miR-18a and miR-93) was identified and their expression levels were tested to be up-regulated in high-metastatic NPC cells relative to low-metastatic ones. CONCLUSION: The present study revealed that five miRNAs (miR-106b, miR-17, miR-20b, miR-18a and miR-93) and several hub genes such as PTEN, KAT2B, CCND1, STAT3, and MAP3K5, might play critical roles in the development of NPC metastasis. +other 32083569 hsa-mir-93 Nasopharyngeal Carcinoma Moreover, a five-miRNA profile (miR-106b, miR-17, miR-20b, miR-18a and miR-93) was identified and their expression levels were tested to be up-regulated in high-metastatic NPC cells relative to low-metastatic ones. CONCLUSION: The present study revealed that five miRNAs (miR-106b, miR-17, miR-20b, miR-18a and miR-93) and several hub genes such as PTEN, KAT2B, CCND1, STAT3, and MAP3K5, might play critical roles in the development of NPC metastasis. +other 32083569 hsa-mir-18a Nasopharyngeal Carcinoma Moreover, a five-miRNA profile (miR-106b, miR-17, miR-20b, miR-18a and miR-93) was identified and their expression levels were tested to be up-regulated in high-metastatic NPC cells relative to low-metastatic ones. CONCLUSION: The present study revealed that five miRNAs (miR-106b, miR-17, miR-20b, miR-18a and miR-93) and several hub genes such as PTEN, KAT2B, CCND1, STAT3, and MAP3K5, might play critical roles in the development of NPC metastasis. +other 32083569 hsa-mir-106b Nasopharyngeal Carcinoma Moreover, a five-miRNA profile (miR-106b, miR-17, miR-20b, miR-18a and miR-93) was identified and their expression levels were tested to be up-regulated in high-metastatic NPC cells relative to low-metastatic ones. CONCLUSION: The present study revealed that five miRNAs (miR-106b, miR-17, miR-20b, miR-18a and miR-93) and several hub genes such as PTEN, KAT2B, CCND1, STAT3, and MAP3K5, might play critical roles in the development of NPC metastasis. +other 32083569 hsa-mir-17 Nasopharyngeal Carcinoma Moreover, a five-miRNA profile (miR-106b, miR-17, miR-20b, miR-18a and miR-93) was identified and their expression levels were tested to be up-regulated in high-metastatic NPC cells relative to low-metastatic ones. CONCLUSION: The present study revealed that five miRNAs (miR-106b, miR-17, miR-20b, miR-18a and miR-93) and several hub genes such as PTEN, KAT2B, CCND1, STAT3, and MAP3K5, might play critical roles in the development of NPC metastasis. +genetics_overexpression_suppress 32083506 hsa-mir-145 Neuroblastoma However, the impact of miR-145 on NB is still ambiguous. Our findings suggest that low miR-145 expression was associated with poor prognosis in patients with NB, and the overexpression of miR-145 inhibited NB cells growth by down-regulating MTDH, thus providing a potential target for the development of microRNA-based approach for NB therapy. +genetics_GWAS 32083300 hsa-mir-34c Wilms Tumor Our results indicated that the association of miR34b/c rs4938723 and TP53 rs1042522 polymorphisms with Wilms tumor susceptibility was not statistically significant. +genetics_GWAS 32083300 hsa-mir-34b Wilms Tumor Our results indicated that the association of miR34b/c rs4938723 and TP53 rs1042522 polymorphisms with Wilms tumor susceptibility was not statistically significant. +lncRNA target 32083281 hsa-mir-203a Cartilage Diseases Collectively, these results demonstrated that miR-203a may contribute to articular cartilage degradation of OA by targeting Smad3, suggesting a novel therapeutic target for the treatment of OA. +other 32083004 hsa-mir-372 Mouth Neoplasms Therefore, silencing miR-372 and/or upregulating ZBTB7A would seem to be promising strategies for enhancing the sensitivity of OSCC to cisplatin therapy. +lncRNA target 32082982 hsa-mir-1227 Osteosarcoma 5p, which might be related to the metastasis of osteosarcoma and could be used as a potential prognostic biomarker and therapeutic target in osteosarcoma. +other 32082362 hsa-mir-199b Breast Neoplasms Moreover, it was found that miR-199b-5p was repressed in breast cancer cells and its expression was decreased during the VEGF-induced angiogenesis process of human umbilical vein endothelial cells (HUVECs). +other 32082120 hsa-mir-34a Ear Diseases Moreover, miR-34a potentially mediated changes in the expression of BDNF and may reflect the decrease in performance after OT. +circRNA target 32082079 hsa-mir-361 Thyroid Neoplasms CONCLUSIONS: Hsa_circ_0011385facilitated thyroid cancer cell proliferation, invasion and migration, and inhibited thyroid cancer cell cycle arrest and apoptosis by targeting miR +other 32082077 hsa-mir-150 Lupus Erythematosus, Cutaneous miR-150, miR-1246, and miR-21 levels were downregulated in DLE. +other 32082077 hsa-mir-1246 Lupus Erythematosus, Cutaneous miR-150, miR-1246, and miR-21 levels were downregulated in DLE. +other 32082077 hsa-mir-21 Lupus Erythematosus, Cutaneous miR-150, miR-1246, and miR-21 levels were downregulated in DLE. +circulation_biomarker_diagnosis_ns 32081976 hsa-mir-4732 Mycobacterium Infections, Nontuberculous 5p) showed significantly higher serum expressions in NTM-PD patients than in controls. +circulation_biomarker_diagnosis_ns 32081976 hsa-mir-625 Mycobacterium Infections, Nontuberculous 5p) showed significantly higher serum expressions in NTM-PD patients than in controls. +circulation_biomarker_diagnosis_ns 32081976 hsa-mir-484 Mycobacterium Infections, Nontuberculous 5p) showed significantly higher serum expressions in NTM-PD patients than in controls. +circulation_biomarker_diagnosis_ns 32081976 hsa-mir-584 Mycobacterium Infections, Nontuberculous 5p) showed significantly higher serum expressions in NTM-PD patients than in controls. +genetics_overexpression_promote 32081926 hsa-mir-1229 Stomach Neoplasms Overexpression of miR +genetics_overexpression_promote 32081805 hsa-mir-4651 Carcinoma, Non-Small-Cell Lung Functional studies demonstrated that NSCLC cell growth, proliferation, and migration were suppressed with ectopic miR-4651 overexpression but enhanced with miR-4651 inhibition. +other 32081771 hsa-mir-129-1 Adenocarcinoma, Follicular Reverse transcription quantitative polymerase chain reaction (RT-qPCR) was applied to determine the expression levels of miR1, miR-146b,-183 and miR-197 in 48 cases (16 FTC, 16 FTA and 16 hyperplasia/multinodular goiter (MNG) cases). +genetics_overexpression_promote 32081771 hsa-mir-146b Adenocarcinoma, Follicular The results of ROC curve analysis determined the significant overexpression and prognostic value of miR +other 32081771 hsa-mir-197 Adenocarcinoma, Follicular Reverse transcription quantitative polymerase chain reaction (RT-qPCR) was applied to determine the expression levels of miR1, miR-146b,-183 and miR-197 in 48 cases (16 FTC, 16 FTA and 16 hyperplasia/multinodular goiter (MNG) cases). +genetics_overexpression_promote 32081769 hsa-mir-21 Osteosarcoma miR-21 is one of the most frequently overexpressed microRNAs in osteosarcoma. +genetics_GWAS 32081695 hsa-mir-629 Stomach Neoplasms DISCUSSION It was predicted that the TT genotype could be dangerous in breast cancer and gastric cancer; it is expected via bioinformatics that this SNP could lead to signaling pathways of cancer progression, by altering the binding potential of miR +genetics_GWAS 32081695 hsa-mir-629 Breast Neoplasms DISCUSSION It was predicted that the TT genotype could be dangerous in breast cancer and gastric cancer; it is expected via bioinformatics that this SNP could lead to signaling pathways of cancer progression, by altering the binding potential of miR +other 32081664 hsa-mir-490 Angelman Syndrome 3p was downregulated in the sera of AS patients and ox-LDL-stimulated HA-VSMCs. +circulation_biomarker_diagnosis_ns 32081186 hsa-mir-21 Gastrointestinal Neoplasms Furthermore, this sensor successfully evaluated the expression level of miRNA-21 in clinical blood samples from healthy individuals and gastrointestinal cancer patients, and the results were highly consistent with those of qRT-PCR, suggesting the great clinical application value in the diagnosis of cancer associated with miRNA-21 expression levels. +genetics_overexpression_promote 32080912 hsa-mir-34c Carcinoma, Hepatocellular Moreover, overexpressed miR-34c-3p and reduced MAGI3 predicted poor clinical outcome and was closely associated with the maximum standard uptake value (SUVmax) in HCC patients who received preoperative (18) F-FDG PET/CT. +other 32080334 hsa-mir-19b Hernias, Diaphragmatic, Congenital miR-16, miR-17, miR-18, miR-19b, and miR-20a had an increased expression, while miR-19a had a twofold decreased expression in CDH patients, compared with age-matched control patients. +other 32080334 hsa-mir-20a Hernias, Diaphragmatic, Congenital miR-16, miR-17, miR-18, miR-19b, and miR-20a had an increased expression, while miR-19a had a twofold decreased expression in CDH patients, compared with age-matched control patients. +other 32080334 hsa-mir-17 Hernias, Diaphragmatic, Congenital miR-16, miR-17, miR-18, miR-19b, and miR-20a had an increased expression, while miR-19a had a twofold decreased expression in CDH patients, compared with age-matched control patients. +other 32080334 hsa-mir-18 Hernias, Diaphragmatic, Congenital miR-16, miR-17, miR-18, miR-19b, and miR-20a had an increased expression, while miR-19a had a twofold decreased expression in CDH patients, compared with age-matched control patients. +other 32080334 hsa-mir-19a Hernias, Diaphragmatic, Congenital miR-16, miR-17, miR-18, miR-19b, and miR-20a had an increased expression, while miR-19a had a twofold decreased expression in CDH patients, compared with age-matched control patients. +other 32080334 hsa-mir-16 Hernias, Diaphragmatic, Congenital miR-16, miR-17, miR-18, miR-19b, and miR-20a had an increased expression, while miR-19a had a twofold decreased expression in CDH patients, compared with age-matched control patients. +other 32080299 hsa-mir-169 Dehydration Results of information theory-based feature selection revealed that miRNA-169, miRNA-159, miRNA-396, and miRNA-393 had the highest contributions to plant response towards drought, salinity, cold, and heat, respectively. +other 32080299 hsa-mir-93 Dehydration Results of information theory-based feature selection revealed that miRNA-169, miRNA-159, miRNA-396, and miRNA-393 had the highest contributions to plant response towards drought, salinity, cold, and heat, respectively. +other 32080251 hsa-mir-517a Epidermodysplasia Verruciformis In situ hybridization for miR-517a/c, a C19MC cistron microRNA, in first trimester human placentas displayed strong expression in villous trophoblasts and a gradual decrease from proximal to distal cell columns as cytotrophoblasts differentiate into invasive EVTs. +other 32080251 hsa-mir-517c Epidermodysplasia Verruciformis In situ hybridization for miR-517a/c, a C19MC cistron microRNA, in first trimester human placentas displayed strong expression in villous trophoblasts and a gradual decrease from proximal to distal cell columns as cytotrophoblasts differentiate into invasive EVTs. +other 32080184 hsa-mir-145 Neoplasms, Multiple Primary Down-regulation of both strands of miR-30a and miR-145 recurrently increased cell cycle pathway genes and significantly reduced patient survival in multiple cancers. +genetics_overexpression_promote 32080097 hsa-mir-1183 Glioma Finally, overexpression of circ_VCAN expedited carcinogenesis and reduced glioma radiosensitivity by regulating miR-1183.Circ_VCAN serves as a potential oncogene of glioma by regulating miR-1183, and plays an essential role in the radioresistance of glioma. +genetics_knock down_promote 32079439 hsa-mir-29b Mitochondrial Diseases Purpose: We aimed at evaluating the feasibility of using MicroRNA (miR)-34a and miR-29b to detect inner ear damage in patients with mitochondrial disease (MD) and sensorineural hearing loss (SNHL).Material and Methods: Three patients with MD and SNHL and seven healthy control subjects were included in this case series. +genetics_knock down_promote 32079439 hsa-mir-34a Mitochondrial Diseases Purpose: We aimed at evaluating the feasibility of using MicroRNA (miR)-34a and miR-29b to detect inner ear damage in patients with mitochondrial disease (MD) and sensorineural hearing loss (SNHL).Material and Methods: Three patients with MD and SNHL and seven healthy control subjects were included in this case series. +genetics_knock down_promote 32079439 hsa-mir-34a Hearing Loss, Sensorineural Purpose: We aimed at evaluating the feasibility of using MicroRNA (miR)-34a and miR-29b to detect inner ear damage in patients with mitochondrial disease (MD) and sensorineural hearing loss (SNHL).Material and Methods: Three patients with MD and SNHL and seven healthy control subjects were included in this case series. +genetics_knock down_promote 32079439 hsa-mir-29b Hearing Loss, Sensorineural Purpose: We aimed at evaluating the feasibility of using MicroRNA (miR)-34a and miR-29b to detect inner ear damage in patients with mitochondrial disease (MD) and sensorineural hearing loss (SNHL).Material and Methods: Three patients with MD and SNHL and seven healthy control subjects were included in this case series. +other 32079424 hsa-mir-486 Cicatrix, Hypertrophic METHODS: Qualitative real-time-polymerase chain reaction (qRT-PCR) was performed to detect the expression of miR5p in HS and hypertrophic scar fibroblasts (HSFBs). +exosome 32079286 hsa-mir-125b Melanoma Thus, our data show for the first time that miR-125b-5p transferred by cutaneous melanoma-derived exosomes induces a tumor-promoting TAM phenotype in macrophages. +circulation_biomarker_diagnosis_ns 32079038 hsa-mir-1258 Recurrence miR-1258 promoter methylation was studied in 147 samples including 10 normal buffy coat, eight normal bone marrow plasma cells, 16 human myeloma cell lines (HMCLs), 20 MGUS, 63 diagnostic myeloma, and 30 relapsed myeloma samples by methylation-specific PCR. In primary samples, miR-1258 methylation, with lower expression of miR-1258, was detected in 49.2% diagnostic myeloma, imparting an inferior PFS (P = 0.034) in addition to 50.0% relapsed myeloma but not MGUS. +circulation_biomarker_diagnosis_up 32079038 hsa-mir-1258 Monoclonal Gammopathy of Undetermined Significance miR-1258 promoter methylation was studied in 147 samples including 10 normal buffy coat, eight normal bone marrow plasma cells, 16 human myeloma cell lines (HMCLs), 20 MGUS, 63 diagnostic myeloma, and 30 relapsed myeloma samples by methylation-specific PCR. +genetics_overexpression_promote 32079038 hsa-mir-1258 Multiple Myeloma Methylation-mediated miR-1258 silencing led to overexpression of PDL1 and inferior PFS, implicating miR-1258 in the modulation of myeloma-specific cytotoxicity. +circulation_biomarker_diagnosis_ns 32079038 hsa-mir-1258 Mucocutaneous Lymph Node Syndrome miR-1258 promoter methylation was studied in 147 samples including 10 normal buffy coat, eight normal bone marrow plasma cells, 16 human myeloma cell lines (HMCLs), 20 MGUS, 63 diagnostic myeloma, and 30 relapsed myeloma samples by methylation-specific PCR. In myeloma lines, miR-1258 methylation, verified by pyrosequencing, was detected in 62.5% HMCLs but not normal controls, and expression of miR-1258 correlated with that of ZNF385B. +lncRNA target 32078829 hsa-mir-126 Aortic Aneurysm, Abdominal CONCLUSIONS: Our data revealed a link between ADAM9 and AAA formation, providing an approach to control AAA development using miR-126, possibly through modulation of the expression level of ADAM9. +genetics_overexpression_suppress 32078828 hsa-mir-99a Stomach Neoplasms Further, high miR-99a-5p expression was found to closely correlate with less aggressive clinicopathological features, and functional studies probed by overexpression of miR-99a-5p resulted in inhibition of proliferation in two SRC cell lines. +lncRNA target 32078403 hsa-mir-129 Glossitis, Benign Migratory Also, the target genes (tyrosinase (TYR), frizzled 6 (FZD6) and glycogen synthase kinase 3beta (GSK3beta)) of miR +lncRNA target 32077748 hsa-mir-377 Prostatic Neoplasms 3p on inhibiting cell growth and promoting apoptosis of PCa cells. +lncRNA target 32077747 hsa-mir-16 Uterine Cervical Neoplasms Conclusions: DLX6-AS1 accelerates the progression of CC through sponging miR +other 32077744 hsa-mir-634 Breast Neoplasms Conclusion: miR-634 was able to regulate STAT3 and enhance the sensitivity of breast cancer cells to radiation; these results might shed new light on radiation therapy for breast cancer. +lncRNA target 32077635 hsa-mir-185 Colonic Neoplasms CONCLUSION: NEAT1 upregulate IGF2 expression through absorbing miR +circulation_biomarker_diagnosis_up 32077624 hsa-mir-338 Carcinoma, Hepatocellular Subsequently, a series of mimic, inhibitor or siRNA plasmids were delivered into HCC cells to validate the effects of hsa_circ_0000092, miR +circulation_biomarker_diagnosis_up 32077254 hsa-mir-150 Parkinson Disease This study aimed to investigate the serum expression of microRNA-150 (miR-150) in Parkinson's disease (PD) patients and further uncover the regulatory effect of miR-150 on neuroinflammation. +other 32077168 hsa-mir-29b Heart Diseases Injection of miR-29b-3p into zebrafish embryos induced higher mortality and malformation rates, developmental delay, cardiac malformation and dysfunction. +other 32077168 hsa-mir-29 Heart Diseases Injection of miR-29b-3p into zebrafish embryos induced higher mortality and malformation rates, developmental delay, cardiac malformation and dysfunction. +other 32077168 hsa-mir-29b Developmental Disabilities Injection of miR-29b-3p into zebrafish embryos induced higher mortality and malformation rates, developmental delay, cardiac malformation and dysfunction. +transcription factor target 32077168 hsa-mir-29b Coronary Disease CONCLUSION: This study reveals that miR-29b-3p functions as a novel regulator of cardiac development and inhibits cardiomyocyte proliferation via NOTCH2, which provides novel insights into the aetiology and potential treatment of CHD. +other 32077168 hsa-mir-29 Cardiovascular Diseases OBJECTIVES: microRNA-29 (miR-29) family have shown different expression patterns in cardiovascular diseases. +other 32077168 hsa-mir-29 Developmental Disabilities Injection of miR-29b-3p into zebrafish embryos induced higher mortality and malformation rates, developmental delay, cardiac malformation and dysfunction. +transcription factor target 32077168 hsa-mir-29 Coronary Disease CONCLUSION: This study reveals that miR-29b-3p functions as a novel regulator of cardiac development and inhibits cardiomyocyte proliferation via NOTCH2, which provides novel insights into the aetiology and potential treatment of CHD. +circulation_biomarker_prognosis_ns 32077163 hsa-mir-125b Sepsis Plasma samples were separated from blood samples obtained from sepsis patients and HCs to detect miR-125a and miR-125b expressions by real-time quantitative polymerase chain reaction. +other 32077150 hsa-mir-497 Kidney Failure, Chronic CONCLUSION MiR-497/FGF-23 axis holds clinical significance for predicting attenuated MACCE risk in ESRD patients who underwent CAPD. +lncRNA target 32077148 hsa-mir-145 Upper Tract Urothelial Carcinoma 5p may suppress UTUC cell motility and invasion by targeting ARF6/MMP7 through EMT. +circulation_biomarker_diagnosis_up 32076458 hsa-mir-22 Endometriosis 3p and miR-320a were significantly upregulated in serum exosomes from patients with endometriosis compared with negative individuals. +circulation_biomarker_diagnosis_up 32076458 hsa-mir-20a Endometriosis 3p and miR-320a were significantly upregulated in serum exosomes from patients with endometriosis compared with negative individuals. +other 32076030 hsa-let-7b Neurofibromatosis 1 3p) in MPNST were selected for functional characterization. +other 32076030 hsa-let-7b Neurilemmoma 3p) in MPNST were selected for functional characterization. +other 32076030 hsa-mir-135b Neurilemmoma 3p) in MPNST were selected for functional characterization. +other 32076030 hsa-mir-135b Neurofibromatosis 1 3p) in MPNST were selected for functional characterization. +other 32076030 hsa-mir-889 Neurilemmoma 3p) in MPNST were selected for functional characterization. +other 32076030 hsa-mir-889 Neurofibromatosis 1 3p) in MPNST were selected for functional characterization. +other 32076030 hsa-mir-145 Neurilemmoma 3p) in MPNST were selected for functional characterization. +other 32076030 hsa-mir-145 Neurofibromatosis 1 3p) in MPNST were selected for functional characterization. +other 32076030 hsa-mir-143 Neurofibromatosis 1 3p) in MPNST were selected for functional characterization. +other 32076030 hsa-mir-143 Neurilemmoma 3p) in MPNST were selected for functional characterization. +transcription factor target 32075600 hsa-mir-92a Sepsis CONCLUSIONS: The utility of hsa-mir-92a-3p as a biomarker for sepsis-induced coagulopathy needs more verification, and the regulatory mechanism of hsa-mir-92a-3p in coagulation disorder and its potency as a therapeutic target must be confirmed. +transcription factor target 32075559 hsa-mir-20 Fanconi Anemia To illustrate its utility, here we show that siRNAs to Fanconi anaemia proteins (FANC-A and FANC-C) and an inhibitor of miRNA-20 upregulate and downregulate human L1 retrotransposition, respectively. +lncRNA target 32075502 hsa-mir-577 Thyroid Cancer, Papillary Rescue experiments revealed that inhibiting miR-577 or restoring Sphk2 could abrogate the effects of LINC00520 silencing on the malignant phenotypes of PTC. LINC00520 functioned as an oncogenic lncRNA in PTC, and it facilitated PTC progression by regulating the miR-577/Sphk2 axis, suggesting that the LINC00520/miR-577/Sphk2 axis is an effective target in anticancer management. +other 32075190 hsa-mir-126 Premature Birth We also discovered that among the significantly down-regulated miRNAs, there were several classical Angio-MiRs (inter alia MiR-125, MiR-126, MiR-145, MiR-150, or MiR155), which are involved in angiogenesis regulation in newborn after preterm delivery. +other 32075190 hsa-mir-150 Premature Birth We also discovered that among the significantly down-regulated miRNAs, there were several classical Angio-MiRs (inter alia MiR-125, MiR-126, MiR-145, MiR-150, or MiR155), which are involved in angiogenesis regulation in newborn after preterm delivery. +other 32075190 hsa-mir-145 Premature Birth We also discovered that among the significantly down-regulated miRNAs, there were several classical Angio-MiRs (inter alia MiR-125, MiR-126, MiR-145, MiR-150, or MiR155), which are involved in angiogenesis regulation in newborn after preterm delivery. +other 32075190 hsa-mir-155 Premature Birth We also discovered that among the significantly down-regulated miRNAs, there were several classical Angio-MiRs (inter alia MiR-125, MiR-126, MiR-145, MiR-150, or MiR155), which are involved in angiogenesis regulation in newborn after preterm delivery. +other 32075129 hsa-mir-221 esophagus adenocarcinoma A tissue micro array of 192 patients with esophageal adenocarcinoma was analyzed immunohistochemically for DKK2, miRNA-221 expression by RNA scope, and GATA6 amplification by fluorescence in-situ hybridization. +transcription factor target 32075123 hsa-mir-129 Multiple Myeloma 5p, which targets different osteoblast (OBs) differentiation markers, is enriched in MM-EVs compared to SMM-EVs, thus suggesting a selective packaging correlated with pathological grade. +other 32074771 hsa-mir-449b Uterine Cervical Neoplasms Objective: To investigate the effects of cancer susceptibility candidate gene 19 (CASC19) regulating the expression of microRNA-449b-5p (miR-449b-5p) on the proliferation, apoptosis and radiation sensitivity of cervical cancer cells. +genetics_overexpression_promote 32074085 hsa-mir-136 Triple Negative Breast Neoplasms 5p expression is decreased in TNBC tissues, and its overexpression suppresses TNBC cell proliferation, migration, and invasion. +lncRNA target 32074070 hsa-mir-206 Carcinoma, Non-Small-Cell Lung In this study, we investigated the involvement of miR-206 in curcumin's anti-invasion and anti-migration in NSCLC. In conclusion, curcumin inhibited cell invasion and migration in NSCLC by elevating the expression of miR-206 which further suppressed the activation of the PI3K/AKT/mTOR pathway. +other 32073999 hsa-mir-607 Thyroid Cancer, Papillary 3p were novel miRNAs associated with PTC metastasis. +other 32073999 hsa-mir-182 Thyroid Cancer, Papillary 3p were novel miRNAs associated with PTC metastasis. +other 32073999 hsa-mir-193 Thyroid Cancer, Papillary 3p were novel miRNAs associated with PTC metastasis. +genetics_overexpression_promote 32073896 hsa-mir-539 Carcinoma, Hepatocellular Transwell assays showed that ZNF281 overexpression led to enhanced and miR-539 overexpression led to suppressed HCC cell invasion and migration. +lncRNA target 32073886 hsa-mir-214 Osteosarcoma Conclusions: Irisin/FNDC5 could inhibit the viability, migration, invasion, and EMT of osteosarcoma cells, and miR +circulation_biomarker_diagnosis_up 32073880 hsa-mir-142 Respiratory Tract Infections In our previously published work, using the conventional RT-qPCR method, we have reported that miR-142 and -223 are dramatically upregulated in both BALF and serum EVs after lung infection. +other 32073729 hsa-mir-136 Endometrial Neoplasms Circ_PUM1 can compete with miR-136, leading to up-regulation of NOTCH3, and thereby promote the development of endometrial cancer. +genetics_knock down_promote 32073706 hsa-mir-375 Colorectal Neoplasms 3p overexpression on the CRC cellular response to 5-FU. +circulation_biomarker_prognosis_down 32073611 hsa-mir-140 Inflammation 5p expression levels with serum proteinuria was observed in DN patients, suggesting miR +circulation_biomarker_prognosis_ns 32073597 hsa-mir-484 Adenocarcinoma of Lung Importantly, we validated candidate miRNAs in lung adenocarcinoma patients before and after surgery as well as in healthy controls and found that miR-484 was significantly increased in the plasma of lung adenocarcinoma patients and strikingly decreased post-surgery. +lncRNA target 32073141 hsa-mir-210 nonpapillary renal cell carcinoma Previously we reported that the microRNA miR-210 is aberrantly upregulated in clear cell renal cell carcinoma (ccRCC) via deregulation of the VHL-HIF pathway. +lncRNA target 32072994 hsa-mir-411 Osteoarthritis MATERIAL AND METHODS We found that miRNA-411 regulates chondrocyte autophagy in OA by targeting hypoxia-inducible factor 1 alpha (HIF-1alpha) and identified the related molecular mechanism. CONCLUSIONS Our results demonstrate that miR-411 promotes chondrocyte autophagy by targeting HIF-1alpha, suggesting that regulating HIF-1alpha by miR-411 might be a therapeutic strategy for OA. +lncRNA target 32072912 hsa-mir-101 Myocardial Infarction CONCLUSION: This research suggested that miR-101 attenuated- MI-induced injury by targeting DDIT4 to regulate autophagy, which indicated that miR-101 or DDIT4 may be potential therapeutic targets for heart injury. +lncRNA target 32072720 hsa-mir-214 Hemangiosarcoma Transfection of HSA cells with synthetic miR-214 (miR-214 5AE) demonstrated significant growth suppressive effect and induced the strongest apoptotic response. +transcription factor target 32072698 hsa-mir-22 Colonic Neoplasms These discoveries manifested that MAT could evoke colon cancer cell apoptosis and G0/G1 cell cycle arrest via elevating miR-22. +transcription factor target 32072603 hsa-mir-92b Pre-Eclampsia This study confirmed that Lin28 acts on DKK1 through miR-92b, which affects the expression of downstream Wnt/beta-catenin, inhibits the invasion of trophoblast cells and the development of placental vasculature, and participates in the occurrence of PE. +lncRNA target 32072570 hsa-mir-103a Obesity CONCLUSION: Exercise combined with diet intervention for 6 weeks was effective in regulating appetite sensations and hormones in obese children, and miR-103a-3p and miR-200a-3p might provide a foundation for target biomarkers of appetite trait in modulating the energy balance control by exercise and dietary intervention. +lncRNA target 32072570 hsa-mir-200a Obesity CONCLUSION: Exercise combined with diet intervention for 6 weeks was effective in regulating appetite sensations and hormones in obese children, and miR-103a-3p and miR-200a-3p might provide a foundation for target biomarkers of appetite trait in modulating the energy balance control by exercise and dietary intervention. +genetics_overexpression_promote 32072565 hsa-mir-106b Glioma Overexpression of miR-106b-5p reversed the inhibitory effects of GAS5-AS1 upregulation on glioma cell proliferation and metastasis, while restoration of TUSC2 rescued the proliferation and invasion of glioma cells transfected with miR-106b-5p mimics. +genetics_knock down_suppress 32072428 hsa-mir-20a Angelman Syndrome Furthermore, OIP5-AS1 knockdown modulated cell progression via regulating miR-320a/LOX1 axis in ox-LDL-treated HUVECs. +lncRNA target 32072405 hsa-mir-501 Squamous Cell Carcinoma of Head and Neck 5p exhibited a tumor-promoting role on HNSCC by targeting CLCA4, providing a new insight for revealing the pathogenesis and treatment of HNSCC. +lncRNA target 32072402 hsa-mir-21 Aortic Dissection Resveratrol or SRT1720-initiated SIRT1 activation ameliorated BAPN-induced AAD symptoms accompanied by the activation of AP-1/decorin signaling and decorin-mediated programmed cell death 4 (PDCD4) expression by inhibiting miR-21 and miR-181b. +lncRNA target 32072402 hsa-mir-181b Aortic Dissection Resveratrol or SRT1720-initiated SIRT1 activation ameliorated BAPN-induced AAD symptoms accompanied by the activation of AP-1/decorin signaling and decorin-mediated programmed cell death 4 (PDCD4) expression by inhibiting miR-21 and miR-181b. +circulation_biomarker_diagnosis_ns 32072174 hsa-mir-622 Inflammatory Bowel Diseases We studied serum expression of miR-622, a newly identified candidate gene, from 32 UC patients and 8 healthy controls by quantitative reverse-transcription polymerase chain reaction. Serum expression of miR-622 in patients with inactive UC tended to be higher than in healthy controls and patients with active UC (inactive UC vs healthy controls, P = 3.03E-02; inactive UC vs active UC, P = 6.44E-02). +circulation_biomarker_diagnosis_up 32072161 hsa-mir-122 Liver Failure OBJECTIVES: This study's purpose was to investigate changes in plasma miR-122, correlate miR-122 with serum liver function tests and enzymes, and investigate changes in whole blood transcripts including miR-122 targets in a group of children with IFALD who received pure intravenous fish oil (FO) as a treatment for cholestasis. +lncRNA target 32072011 hsa-mir-570 Urinary Bladder Neoplasms In conclusion, circFUT8 functions as a tumor suppressor in BCa cells by targeting the miR3p/KLF10 axis and may serve as a potential biomarker and therapeutic target for the management of BCa patients with LN metastasis. +genetics_knock down_suppress 32071552 hsa-mir-9 Carcinoma, Hepatocellular HCC cells overexpressing miR-9 were more sensitive to cisplatin; miR-9 knockdown yielded the opposite result. +circulation_biomarker_diagnosis_ns 32071343 hsa-mir-4435 Colorectal Neoplasms In conclusion, our results identified miR-4435 as a potential circulating miRNA biomarker of colorectal cancer associated with UQCRB. +other 32071155 hsa-mir-27a Hypercholesterolemia Taken together, miR-27a emerges as a key regulator of cholesterol biosynthesis and has therapeutic potential for the clinical management of hypercholesterolemia. +other 32070749 hsa-mir-34b Azoospermia Azo rats injected with MSCs also exhibited a significant downregulated expression of miRNA-19b, miRNA-100, miRNA-141, miRNA146a, miRNA-429, and let7a and a significant upregulated expression of miRNA-21, miRNA-34b, miRNA-34c, miRNA-122, miRNA-449a, miRNA-449b, and miRNA-449c in the testis as compared to Azo rats injected with phosphate buffer saline. +other 32070749 hsa-let-7a Azoospermia Azo rats injected with MSCs also exhibited a significant downregulated expression of miRNA-19b, miRNA-100, miRNA-141, miRNA146a, miRNA-429, and let7a and a significant upregulated expression of miRNA-21, miRNA-34b, miRNA-34c, miRNA-122, miRNA-449a, miRNA-449b, and miRNA-449c in the testis as compared to Azo rats injected with phosphate buffer saline. +other 32070749 hsa-mir-19b Azoospermia Azo rats injected with MSCs also exhibited a significant downregulated expression of miRNA-19b, miRNA-100, miRNA-141, miRNA146a, miRNA-429, and let7a and a significant upregulated expression of miRNA-21, miRNA-34b, miRNA-34c, miRNA-122, miRNA-449a, miRNA-449b, and miRNA-449c in the testis as compared to Azo rats injected with phosphate buffer saline. +other 32070749 hsa-mir-34c Azoospermia Azo rats injected with MSCs also exhibited a significant downregulated expression of miRNA-19b, miRNA-100, miRNA-141, miRNA146a, miRNA-429, and let7a and a significant upregulated expression of miRNA-21, miRNA-34b, miRNA-34c, miRNA-122, miRNA-449a, miRNA-449b, and miRNA-449c in the testis as compared to Azo rats injected with phosphate buffer saline. +other 32070749 hsa-mir-146a Azoospermia Azo rats injected with MSCs also exhibited a significant downregulated expression of miRNA-19b, miRNA-100, miRNA-141, miRNA146a, miRNA-429, and let7a and a significant upregulated expression of miRNA-21, miRNA-34b, miRNA-34c, miRNA-122, miRNA-449a, miRNA-449b, and miRNA-449c in the testis as compared to Azo rats injected with phosphate buffer saline. +other 32070749 hsa-mir-100 Azoospermia Azo rats injected with MSCs also exhibited a significant downregulated expression of miRNA-19b, miRNA-100, miRNA-141, miRNA146a, miRNA-429, and let7a and a significant upregulated expression of miRNA-21, miRNA-34b, miRNA-34c, miRNA-122, miRNA-449a, miRNA-449b, and miRNA-449c in the testis as compared to Azo rats injected with phosphate buffer saline. +other 32070749 hsa-mir-449c Azoospermia Azo rats injected with MSCs also exhibited a significant downregulated expression of miRNA-19b, miRNA-100, miRNA-141, miRNA146a, miRNA-429, and let7a and a significant upregulated expression of miRNA-21, miRNA-34b, miRNA-34c, miRNA-122, miRNA-449a, miRNA-449b, and miRNA-449c in the testis as compared to Azo rats injected with phosphate buffer saline. +other 32070749 hsa-mir-34 Azoospermia Azo rats injected with MSCs also exhibited a significant downregulated expression of miRNA-19b, miRNA-100, miRNA-141, miRNA146a, miRNA-429, and let7a and a significant upregulated expression of miRNA-21, miRNA-34b, miRNA-34c, miRNA-122, miRNA-449a, miRNA-449b, and miRNA-449c in the testis as compared to Azo rats injected with phosphate buffer saline. +other 32070749 hsa-mir-122 Azoospermia Azo rats injected with MSCs also exhibited a significant downregulated expression of miRNA-19b, miRNA-100, miRNA-141, miRNA146a, miRNA-429, and let7a and a significant upregulated expression of miRNA-21, miRNA-34b, miRNA-34c, miRNA-122, miRNA-449a, miRNA-449b, and miRNA-449c in the testis as compared to Azo rats injected with phosphate buffer saline. +other 32070749 hsa-mir-141 Azoospermia Azo rats injected with MSCs also exhibited a significant downregulated expression of miRNA-19b, miRNA-100, miRNA-141, miRNA146a, miRNA-429, and let7a and a significant upregulated expression of miRNA-21, miRNA-34b, miRNA-34c, miRNA-122, miRNA-449a, miRNA-449b, and miRNA-449c in the testis as compared to Azo rats injected with phosphate buffer saline. +other 32070749 hsa-mir-449a Azoospermia Azo rats injected with MSCs also exhibited a significant downregulated expression of miRNA-19b, miRNA-100, miRNA-141, miRNA146a, miRNA-429, and let7a and a significant upregulated expression of miRNA-21, miRNA-34b, miRNA-34c, miRNA-122, miRNA-449a, miRNA-449b, and miRNA-449c in the testis as compared to Azo rats injected with phosphate buffer saline. +other 32070749 hsa-mir-21 Azoospermia Azo rats injected with MSCs also exhibited a significant downregulated expression of miRNA-19b, miRNA-100, miRNA-141, miRNA146a, miRNA-429, and let7a and a significant upregulated expression of miRNA-21, miRNA-34b, miRNA-34c, miRNA-122, miRNA-449a, miRNA-449b, and miRNA-449c in the testis as compared to Azo rats injected with phosphate buffer saline. +lncRNA target 32070140 hsa-mir-200b Pulmonary Emphysema In conclusion, our results suggest that miR-200b may attenuate cellular senescence and inflammatory responses by targeting ZEB2 in pulmonary emphysema. +transcription factor target 32070036 hsa-mir-34a Drug Hypersensitivity These results revealed that both time delay and miR-34a can have tumor suppressing roles by promoting p53 oscillation or high level expression, which will provide a perspective for promoting the development of anti-cancer drugs by targeting miR-34a and time delay. +transcription factor target 32069901 hsa-mir-7 Rotavirus Infections MiR-7 is able to inhibit rotavirus replication in vitro and in vivo. These data provide that understanding the role of cellular miR-7 during rotaviral replication may help in the identification of novel therapeutic small RNA molecule drug for anti-rotavirus. +other 32069774 hsa-let-7b Pneumonia, Mycoplasma The expression of microRNA let-7b and forkhead box protein O1 (FOXO1) was characterized in placental tissues of PE patients. We found that let-7b was highly expressed and FOXO1 was poorly expressed in placental tissues of PE patients. +other 32069773 hsa-mir-1 Alzheimer Disease mediated modulation of APP and BACE1 can become a therapeutic option in the treatment of AD. +other 32069703 hsa-mir-433 Colonic Neoplasms 3p) and Annexin A2 (ANXA2). +lncRNA target 32069387 hsa-mir-21 Urinary Bladder Neoplasms GAS5 could exert antiproliferative and proapoptotic effects on bladder cancer cells through miR-21 and PTEN. +genetics_overexpression_promote 32069125 hsa-mir-15b Colonic Neoplasms As miRNA to be targeted, miR-15b-5p was selected on the basis of several information present in the literature and confirming that miR-15b-5p is overexpressed in colon cancer patients, and that its targeting decreases cell migration and metastasis in colorectal cancer. +circulation_biomarker_prognosis_up 32068453 hsa-mir-632 Squamous Cell Carcinoma of Head and Neck Furthermore, patients with higher serum miR-632 expression had a shorter OS and DFS time than those with lower serum miR-632 levels.Conclusion: Our data revealed that serum miR-632 may be a potential noninvasive biomarker which may become a potential diagnostic and prognostic biomarker for LSCC patients. +transcription factor target 32068322 hsa-mir-93 Colorectal Neoplasms 5p is expected to be a novel target for CRC treatment since it decreases the migration and invasion, as well as the immune evasion, of CRC cells via targeting PD-L1. +genetics_GWAS 32068312 hsa-mir-34a Carcinoma, Non-Small-Cell Lung We show that MiD levels are pathologically elevated in NSCLC and IBC by an epigenetic mechanism (decreased microRNA-34a-3p expression). +genetics_GWAS 32068312 hsa-mir-34a Inflammatory Breast Neoplasms We show that MiD levels are pathologically elevated in NSCLC and IBC by an epigenetic mechanism (decreased microRNA-34a-3p expression). +other 32068261 hsa-mir-136 Carcinoma, Hepatocellular 5p) and with-no-K (lysine) kinase 1 (WNK1). +lncRNA target 32068173 hsa-mir-17 Meningioma Considering the recurrence and irresectability for some meningiomas, which require further treatment, MIR17HG may be a new target for treatment in meningiomas and our study will shed light on further studies. +transcription factor target 32068029 hsa-mir-23a Arthritis, Rheumatoid Overall, our findings endorsed that miR-23a possesses a multifaceted therapeutic efficiency like berberine in RA pathogenesis and can be considered as a potential candidate for therapeutic targeting of Wnt1/beta-catenin signaling in RA disease condition. +genetics_overexpression_promote 32067385 hsa-mir-204 Leukemia, Myeloid, Acute 5p overexpression also regulated the expression of E-cadherin, N-cadherin and Twist1. +transcription factor target 32067333 hsa-mir-182 Reperfusion Injury, Renal Ischemia Additionally, we investigated the relationship between miR-182 and fibrotic protein by transfecting miR-182 mimics and miR-182 inhibitor into polycystic kidney cyst-lined epithelial cells, respectively. +transcription factor target 32067333 hsa-mir-182 polycystic kidney disease 3 Additionally, we investigated the relationship between miR-182 and fibrotic protein by transfecting miR-182 mimics and miR-182 inhibitor into polycystic kidney cyst-lined epithelial cells, respectively. +lncRNA target 32067269 hsa-mir-27a Thymoma We demonstrated that CUR blocked mTOR and Notch 1 pathways via downregulating miR-27a, thereby suppressing cell growth, migration, and invasion of thymic carcinoma cells. +other 32067207 hsa-mir-874 Retinoblastoma 3p / TFAP2B (transcription factor activating enhancer-binding protein 2B) pathway contributes to the progression of RB, which may provide novel insights into the function of lncRNA-driven retinoblastogenesis. +lncRNA target 32067150 hsa-mir-126 Brain Ischemia This study investigated how miR-126 changes with reperfusion time in different brain tissues after global cerebral ischemia and focal cerebral ischemia and examined the underlying mechanism miR-126 involving VEGFA, SPRED1, and Raf-1 after I-R. The reduction of miR-126 expression after global and focal cerebral ischemia exacerbated neuronal death, which was closely related to increasing the SPRED1 activation and inhibiting the Raf-1 expression. +transcription factor target 32066912 hsa-mir-4711 Colonic Neoplasms Finally, we found that miR5p had a potent tumour-suppressive effect compared with a putative anti-oncomiR, miR-34a, in tumour cell cultures derived from five patients with colorectal cancer. +transcription factor target 32066912 hsa-mir-34a Colonic Neoplasms Finally, we found that miR5p had a potent tumour-suppressive effect compared with a putative anti-oncomiR, miR-34a, in tumour cell cultures derived from five patients with colorectal cancer. +other 32066878 hsa-mir-590 Corneal dystrophy, epithelial basement membrane The positive correlation of acv3UTR and YAP1 expression, and the negative correlation of acv3UTR and miR5p expression, were verified in GC patients. +genetics_overexpression_suppress 32066826 hsa-mir-27a Breast Neoplasms In addition, overexpression of hsa-miR-27a sensitized breast cancer cells to anticancer drugs by downregulation of genes essential for detoxification of reactive oxygen species (ROS) and impairment of autophagy. +lncRNA target 32066630 hsa-mir-4516 Hirschsprung Disease Recent studies have shown that miR-4516 markedly inhibits cell migration, and as one of its potential targets, MAPK10 functions as a modifier for developing HSCR. +lncRNA target 32066502 hsa-mir-34a Osteoarthritis CONCLUSION: SNHG7 sponged miR-34a-5p to affect cell proliferation, apoptosis and autophagy through targeting SYVN1 which provides a novel sight into the pathogenesis of OA. +other 32066445 hsa-mir-181b Diabetes Mellitus, Type 2 Reduced miR-181b levels contribute to increased thrombogenicity and may help to identify individuals at particular risk for thrombosis. +transcription factor target 32066039 hsa-mir-3 Erectile Dysfunction treated with ICA II recovered the erectile function of BCNI model rats through regulation of miR-33. CONCLUSION: ICA II contributed to the differentiation of ADSCs to SCs viamiR-33/GDNF axis, contributing to the recovery of erectile function in BCNI rats. +other 32066005 hsa-mir-16 Carcinoma, Hepatocellular The purpose of this study was to investigate the potential function of miR-16 in the hepatocellular toxicity and cell cycle alteration induced by MC-LR in human hepatocellular carcinoma (HepG2) cells after treatment with 10 muM MC-LR. +other 32066005 hsa-mir-16 Liver Diseases The purpose of this study was to investigate the potential function of miR-16 in the hepatocellular toxicity and cell cycle alteration induced by MC-LR in human hepatocellular carcinoma (HepG2) cells after treatment with 10 muM MC-LR. +circulation_biomarker_prognosis_ns 32065786 hsa-mir-484 Ovarian Neoplasms CONCLUSIONS: Collectively, serum exosomal miR-484 could serve as a reliable and non-invasive marker for predicting the prognosis of OC. +lncRNA target 32065781 hsa-mir-424 Ischemic Stroke 5p, which targeted Sema3A and the activated MAPK pathway. +other 32065779 hsa-mir-511 Urinary Bladder Neoplasms CircRNA_103809, the top one among the highly expressed circRNA identified in BCSCs, promotes the self-renewal, migration and invasion capabilities of bladder cancer by acting as a miR-511 sponge. +lncRNA target 32065547 hsa-mir-129 Neuralgia 5p suppression attenuated the inhibitory effect of MALAT1 inhibition on neuropathic pain and neuroinflammation development in CCI rats.Conclusion: The present study demonstrates that MALAT1 might modulate neuropathic pain via targeting miR +lncRNA target 32065361 hsa-mir-205 Colorectal Neoplasms Taken together, lncRNA NEAT1 was found to be upregulated in CRC cell lines, promoting CRC cell proliferation, migration, and invasion through regulating the miR +genetics_overexpression_promote 32065219 hsa-mir-492 Stomach Neoplasms In addition, our research results indicated that the inhibition of miR-492 stimulates GC stemness, and the overexpression of miR-492 induces GC stemness. +lncRNA target 32065218 hsa-mir-612 Esophageal Squamous Cell Carcinoma Mechanistically, ZFPM2-AS1 promoted ESCC cell growth and up-regulated TRAF4 to trigger NF-kappaB pathway by sequestering miR-3612. Besides, miR-3612 was confirmed to be a tumor inhibitor in ESCC. +circulation_biomarker_prognosis_ns 32065214 hsa-mir-106b Colorectal Neoplasms Collectively, our study indicated that metastasis-associated miR-106b-3p from serum exosomes could be used as a potential prognostic biomarker and therapeutic target for CRC patients. +circulation_biomarker_diagnosis_up 32065213 hsa-mir-203a Asthma MiR-203a-3p was down-regulated and SIX1 was up-regulated in asthma serums, respectively. +genetics_GWAS 32065054 hsa-mir-214 Hypertension Translationally, we show that miR-214 is increased in plasma of patients with hypertension and is directly correlated to pulse wave velocity as a measure of vascular stiffness. +other 32065051 hsa-mir-410 Colorectal Neoplasms Levels of MiR-410 might a useful laboratory tool in managing and predicting the prognosis of colorectal cancer. +other 32065044 hsa-mir-22 Reperfusion Injury However, the neuroprotective effect of miR-22 in ischemia/reperfusion (I/R) injury has not been thoroughly elucidated. +genetics_knock down_promote 32064885 hsa-mir-638 gastric cardia adenocarcinoma Overexpression of miR-638 or knockdown of MACC1 inhibited cell proliferation, migration and invasion but increased apoptosis in GCA cells. +circulation_biomarker_diagnosis_up 32064884 hsa-mir-769 Squamous Cell Carcinoma of Head and Neck 5p has been reported to be downregulated in tissues and blood of OSCC patients. +lncRNA target 32064882 hsa-mir-22 Stomach Neoplasms Taken together, RGMB-AS1 contributes to the progression of GC by regulating miR3p/NFIB axis, indicating a new therapeutic target for GC treatment. +genetics_knock down_promote 32064777 hsa-mir-20a Osteosarcoma In this study, we show that the overexpression of miR-320a or knockdown of cytoplasmic polyadenylation element-binding protein 1 (CPEB1) inhibited osteosarcoma cell migration and invasion. +lncRNA target 32064660 hsa-mir-551b Cholangiocarcinoma MIAT contributed to the growth of CCA cells by targeting miR-551b-3p/CCND1 axis. +lncRNA target 32064615 hsa-mir-203b Colorectal Neoplasms Our research demonstrated that LINC02595 is an oncogene in CRC and established the presence of a LINC02595-miR-203b-BCL2L1 axis in CRC, which might provide a new diagnostic biomarker and therapeutic targets for the treatment of this disease. +circulation_biomarker_prognosis_up 32064546 hsa-mir-142 Myocardial Infarction, Acute CONCLUSION: The serum level of miR-142 was increased in AMI patients when compared with health population. +lncRNA target 32064235 hsa-mir-34a Thyroid Neoplasms Furthermore, miR-34a-5p targeted the 3' untranslated region of TK1 and suppressed the expression of TK1 in thyroid carcinoma cell lines. +genetics_overexpression_promote 32064152 hsa-mir-193a Pancreatic Carcinoma Overexpression of miR-193a-5p contributed to the metastasis of pancreatic cancer cells both in vitro and in vivo. +transcription factor target 32063865 hsa-mir-29b Diabetic Retinopathy MiR-29b-3p/SIRT1 may be a potential therapeutic target for DR. +genetics_overexpression_suppress 32063748 hsa-mir-450b Stomach Neoplasms Finally, the results of the reverse experiment confirmed that overexpression of KLF7 could reverse miR-450b-3p mimic induced-inhibition of GC malignant progression. +other 32063549 hsa-mir-199a Fetal Growth Retardation RESULTS Placental miR-199a-5p was significantly upregulated in sFGR-T (p = 0.004), which was validated by qRT-PCR (1.03 vs 0.56; p = 0.020). DISCUSSION Our results suggested miR-199a-5p may play a role in the placental angiogenesis, oxidative stress and mitochondrial damage and dysfunction as an underlying pathogenesis of sFGR. +genetics_knock down_promote 32062619 hsa-mir-483 Acute Lung Injury Knockdown of miR +genetics_knock down_promote 32062619 hsa-mir-483 Sepsis Knockdown of miR +genetics_knock down_promote 32062618 hsa-mir-140 Diabetes Mellitus 5p knockdown against isoflurane-aggravated neurotoxicity in diabetic rats via SNX12, suggesting a novel target for neuroprotection in diabetes under isoflurane treatment. +tissue_expression_ns 32062612 hsa-mir-24 Precursor Cell Lymphoblastic Leukemia-Lymphoma CONCLUSIONS: miR3p/PIM-2/XIAP signaling contributes to BBR-mediated leukemia mitigation in p53-defect ALL, which should be further developed as a treatment strategy in ALL patients with p53 deficiency. +lncRNA target 32062610 hsa-mir-101 Osteoarthritis Overall, the LINC00623/miR-101/HRAS axis modulates OA chondrocyte apoptosis, senescence and ECM degradation through MAPK signaling, which might play a critical role in OA development. +genetics_knock down_promote 32062551 hsa-mir-130a Carcinoma, Hepatocellular In conclusion, knockdown of HOTAIR suppressed glycolysis by regulating miR-130a-3p and HIF1A in HCC cells treated by hypoxia, elucidating a novel mechanism in HCC glycolysis. +lncRNA target 32062549 hsa-mir-383 Adenocarcinoma of Lung 5p could target TMPO-AS1, and our data showed that TMPO-AS1 was negatively correlated with mir +lncRNA target 32062455 hsa-mir-34 Lung Neoplasms In this study we performed a high-throughput screen of a large panel of small molecules with known biological activity and identified ouabain as a candidate small molecule that synergized with miR-34a in killing lung cancer cells. +lncRNA target 32062455 hsa-mir-34a Lung Neoplasms In this study we performed a high-throughput screen of a large panel of small molecules with known biological activity and identified ouabain as a candidate small molecule that synergized with miR-34a in killing lung cancer cells. +other 32062383 hsa-mir-98 Cholangiocarcinoma In conclusion, HEIH promoted CHOL tumorigenesis and progression by miR5p/HECTD4 axis, which opens up a new insight for CHOL therapeutics. +other 32062354 hsa-mir-18a Glioma In addition, microRNA-18a had a promoting effect on gliomas, and was the possible reason for low RORA expression in gliomas. +genetics_knock down_promote 32061951 hsa-mir-1246 Carcinoma, Hepatocellular Either overexpression of miR-1246 or knockdown of RORalpha enhanced the proliferation, invasiveness, and metastatic capability of HCC both in vitro and in vivo, through Wnt/beta-catenin pathway activation and promotion of epithelial-mesenchymal transition (EMT). +other 32061643 hsa-mir-181a Liver Diseases Aging and biomarkers: Transcriptional levels evaluation of Osteopontin/miRNA-181a axis in hepatic tissue of rats in different age ranges. +circRNA target 32061262 hsa-mir-422a Nasopharyngeal Carcinoma Mechanistically, RNA immunoprecipitation, luciferase reporter assay, pull-down assay with biotinylated miRNA, fluorescent in situ hybridization were performed to confirm the interaction between circCRIM1 and miR-422a in NPC. Mechanistically, circCRIM1 competitively bound to miR-422a and prevented the suppressive effects of miR-422a on its target gene FOXQ1, which finally led to NPC metastasis, EMT and docetaxel chemoresistance. +lncRNA target 32061171 hsa-mir-122 Reperfusion Injury, Cerebral Ischemia CONCLUSIONS Inhibition of miR-122 can decrease cerebral ischemia-reperfusion injury by upregulating DJ +other 32061123 hsa-mir-133a Hyperlipoproteinemia Type II Mechanistically, miR-133a is directly related with lipid- and inflammatory signalling in key cells for atherosclerosis progression. +circulation_biomarker_diagnosis_up 32061112 hsa-mir-103 Fibrosis 3p in serum exosomes from liver fibrosis patients could be a biomarker for liver fibrosis. +other 32061057 hsa-mir-93 Colorectal Neoplasms 5p/HIF-1A/AXL signaling pathway, which will supply a novel perspective to diagnose and treat colorectal cancer disease. +genetics_overexpression_promote 32061007 hsa-mir-378 Carcinoma, Non-Small-Cell Lung RESULTS: Our results showed that serum exosomal miR-378 was significantly overexpressed in NSCLC patients, and serum exosomal miR-378 upregulation was clearly associated with positive lymph node metastasis and advanced TNM stage. +other 32060985 hsa-mir-701 Fractures, Bone Taken together, our results indicate that the KCNQ1OT1/miR3p/FGFR3 axis is an important regulator of osteoblast proliferation, migration, and apoptosis, and provide a new therapeutic avenue for fracture healing. +lncRNA target 32060632 hsa-mir-216a Urinary Bladder Neoplasms CONCLUSIONS: In bladder cancer tumor samples, samples down-regulated by LINC01198, PPTRD-AS1, has-miR-216a, SEMA3D, EPHA5, and DCLK1 had a good overall survival prognosis, indicating that these several characteristic target molecules were found to be high-risk factors for bladder cancer tumors. +other 32060266 hsa-mir-674 Brain Ventricle Enlargement 3p-Drd1 mechanism contributes to deceleration of ciliary motility and age-dependent ventricular enlargement in 22q11DS. +other 32060266 hsa-mir-382 Schizophrenia 3p-Drd1 mechanism contributes to deceleration of ciliary motility and age-dependent ventricular enlargement in 22q11DS. +other 32060266 hsa-mir-382 Brain Ventricle Enlargement 3p-Drd1 mechanism contributes to deceleration of ciliary motility and age-dependent ventricular enlargement in 22q11DS. +other 32060266 hsa-mir-674 Schizophrenia 3p-Drd1 mechanism contributes to deceleration of ciliary motility and age-dependent ventricular enlargement in 22q11DS. +genetics_overexpression_promote 32060259 hsa-mir-378a Melanoma We also demonstrated that overexpression of miR-378a-5p enhances in vitro cell invasion and migration, and facilitates the ability of melanoma cells to form de novo vasculogenic structures. +exosome 32060049 hsa-mir-195 Osteosarcoma Studies in vitro and in vivo have proved that osteosarcoma-secreted exosomes from miR +genetics_GWAS 32059753 hsa-mir-215 Leukemia, Myeloid, Acute SMC1A regulation is potentially modulated by NPM1 mutation, which might serve as an explanation for the better outcome in NPM1 mutated AML. +circulation_biomarker_diagnosis_ns 32059493 hsa-mir-146a arteriosclerotic cardiovascular disease We also demonstrated that (1) circulating MVs contain miRNAs; this was demonstrated by validating MVs and MVEs as transporters of Ago2-miRNA, Stau1-miRNA, and Stau2-miRNA complexes and (2) MV and MVE administration significantly protect against atherosclerotic cardiovascular disease via transfer of miR-223, miR-21, miR-126, and miR-146a to circulating late EPCs. Our findings suggest that allogenic MV and MVE administration of healthy origins could counteract HH diet-induced detrimental effects by biologically active miR-10a, miR-21, miR-126, and miR-146a transfer to circulating EPCs, mediating their vascular repair function in atherosclerosis processes. +circulation_biomarker_diagnosis_ns 32059493 hsa-mir-21 arteriosclerotic cardiovascular disease We also demonstrated that (1) circulating MVs contain miRNAs; this was demonstrated by validating MVs and MVEs as transporters of Ago2-miRNA, Stau1-miRNA, and Stau2-miRNA complexes and (2) MV and MVE administration significantly protect against atherosclerotic cardiovascular disease via transfer of miR-223, miR-21, miR-126, and miR-146a to circulating late EPCs. Our findings suggest that allogenic MV and MVE administration of healthy origins could counteract HH diet-induced detrimental effects by biologically active miR-10a, miR-21, miR-126, and miR-146a transfer to circulating EPCs, mediating their vascular repair function in atherosclerosis processes. +circulation_biomarker_diagnosis_ns 32059493 hsa-mir-126 arteriosclerotic cardiovascular disease We also demonstrated that (1) circulating MVs contain miRNAs; this was demonstrated by validating MVs and MVEs as transporters of Ago2-miRNA, Stau1-miRNA, and Stau2-miRNA complexes and (2) MV and MVE administration significantly protect against atherosclerotic cardiovascular disease via transfer of miR-223, miR-21, miR-126, and miR-146a to circulating late EPCs. Our findings suggest that allogenic MV and MVE administration of healthy origins could counteract HH diet-induced detrimental effects by biologically active miR-10a, miR-21, miR-126, and miR-146a transfer to circulating EPCs, mediating their vascular repair function in atherosclerosis processes. +circulation_biomarker_diagnosis_ns 32059493 hsa-mir-223 arteriosclerotic cardiovascular disease We also demonstrated that (1) circulating MVs contain miRNAs; this was demonstrated by validating MVs and MVEs as transporters of Ago2-miRNA, Stau1-miRNA, and Stau2-miRNA complexes and (2) MV and MVE administration significantly protect against atherosclerotic cardiovascular disease via transfer of miR-223, miR-21, miR-126, and miR-146a to circulating late EPCs. +other 32059338 hsa-let-7c Myasthenia Gravis Subsequent experiments indicated that SNHG16 regulates the expression of the key MG gene interleukin (IL)-10 by sponging let-7c-5p in a ceRNA manner. +exosome 32059163 hsa-mir-125a Fibrosis As expected, levels of miR-125a-5p were upregulated in human serous exosomes and vitro, and inhibit the exosomal miR-125a-5p suppressed the expression of the fibrosis hallmarks. +genetics_overexpression_suppress 32058347 hsa-mir-216b Stomach Neoplasms In addition, miR-216b overexpression inhibits proliferation, migration, invasion, cell cycle and apoptosis of gastric cancer cells. +genetics_overexpression_suppress 32058347 hsa-mir-216 Stomach Neoplasms In addition, miR-216b overexpression inhibits proliferation, migration, invasion, cell cycle and apoptosis of gastric cancer cells. +lncRNA target 32058222 hsa-mir-490 Triple Negative Breast Neoplasms Altogether, LINC00173 functions as an oncogene in TNBC through antagonization of miR +genetics_knock down_suppress 32058221 hsa-mir-145 Nasopharyngeal Carcinoma Notably, knockdown of miR-145 or overexpression of Smad2 rescued the inhibition of MACC1-AS1 knockdown on the stemness of NPC cells. Therefore, these results demonstrate a novel MACC1-AS1/miR-145/Smad2 negative loop responsible for NPC cell stemness. +genetics_knock down_suppress 32058219 hsa-mir-1305 Uterine Cervical Neoplasms Knockdown of ASB16-AS1 reduced CC cells proliferation, migration and invasion abilities by regulating miR-1305 in vitro and in vivo. +genetics_overexpression_promote 32058212 hsa-mir-6089 Ovarian Neoplasms Mechanistic studies confirmed that miR-6089 directly targeted MYH9 to inactivate the Wnt/beta-catenin signalling pathway and its downstream epithelial-to-mesenchymal transition (EMT), cell-cycle factors and c-Jun, whereas overexpression of MYH9 reversed the inhibitory effects of miR-6089 overexpression in ovarian cancer cells by upregulating the Wnt/beta-catenin and its downstream EMT, cell-cycle factors and c-Jun. +lncRNA target 32058209 hsa-mir-18b Ovarian Neoplasms Furthermore, miR-18b-5p suppresses ovarian carcinoma cell proliferation and metastasis by targeting VMA21 and LOXL1-AS1 regulates ovarian carcinoma cell growth and metastasis through sponging miR-18b-5p. These findings suggest that lncRNA LOXL1-AS1 promotes ovarian cancer cell growth, migratory and invasiveness via modulating miR-18b-5p/VMA21 axis. +genetics_knock down_promote 32057951 hsa-mir-125b Parkinson Disease RESULTS: Our results showed that BDNF-AS was up-regulated in MPTP-induced PD model and dopamine neurons, and MPP+treated SH-SY5Y cells, while miR-125b-5p was down-regulated. CONCLUSIONS: Our study demonstrated that knockdown of BDNF-AS could elevate SH-SY5Y cell viability, inhibit autophagy and apoptosis in MPTP-induced PD models through regulating miR-125b-5p, suggesting that BDNF-AS might act as a potential therapeutic target for PD. +transcription factor target 32057731 hsa-mir-638 Lung Diseases RESULTS: MCT resulted in significant pulmonary vascular remodeling and down-regulation of miR-638, which could be suppressed by resveratrol. CONCLUSION: Our data indicated that resveratrol prevented MCT-induced pulmonary vascular remodeling via miR-638 regulating NR4A3/cyclin D1 pathway. +transcription factor target 32057517 hsa-mir-96 Uterine Cervical Neoplasms Therefore, inhibition of miR-96 might suppress growth, proliferation of CC cells and promote apoptosis of CC cells both in vitro and in vivo. +exosome 32057365 hsa-mir-1263 Osteoporosis We hypothesized that exosomes derived from human umbilical cord mesenchymal stem cells (HUCMSCs) could reduce bone marrow mesenchymal stem cell (BMSC) apoptosis in rat DOP via the miR-1263/Mob1/Hippo signaling pathway. +genetics_overexpression_suppress 32057163 hsa-mir-16 Breast Neoplasms Here, we studied the impact of exogenous induction of miR-16 in MDA-MB-231 and SK-BR-3 breast cancer cells following overexpression of miR-302/367 cluster and investigated whether transfection of these cells by a mature miR-16 mimic could affect the reprogramming state of the cells and their tumorigenicity. Meanwhile, inhibition of miR-16 counteracted both the reprogramming effect and the antitumor function of miR-302/367 in the breast cancer cells. +genetics_overexpression_suppress 32057163 hsa-mir-367 Breast Neoplasms Here, we studied the impact of exogenous induction of miR-16 in MDA-MB-231 and SK-BR-3 breast cancer cells following overexpression of miR-302/367 cluster and investigated whether transfection of these cells by a mature miR-16 mimic could affect the reprogramming state of the cells and their tumorigenicity. Meanwhile, inhibition of miR-16 counteracted both the reprogramming effect and the antitumor function of miR-302/367 in the breast cancer cells. +genetics_overexpression_promote 32056785 hsa-mir-139 Pre-Eclampsia Overexpression of sFlt-1 attenuated the effects of miR +transcription factor target 32056303 hsa-mir-22 Bone Diseases CONCLUSIONS: The findings of the present study highlight the functional significance of miR-22 in osteoblast differentiation and suggest its role as a possible therapeutic target in metabolic bone disorders. +genetics_overexpression_promote 32056164 hsa-mir-498 Stomach Neoplasms Moreover, functional analyses show that the overexpression of miR-498 inhibited the progression of GC. +other 32056133 hsa-mir-338 Growth Disorders 5p was downregulated in placental tissues supporting larger twins of sIUGR, whereas epidermal growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1) was upregulated. +lncRNA target 32056051 hsa-mir-203 Inflammation LncRNA UCA1 inhibited the inflammation via regulating miR-203 mediated regulation of MEF2C/NF-kappaB signaling in epilepsy. +lncRNA target 32056051 hsa-mir-203 Epilepsy LncRNA UCA1 inhibited the inflammation via regulating miR-203 mediated regulation of MEF2C/NF-kappaB signaling in epilepsy. +other 32056038 hsa-mir-152 Melanoma Our study highlights the crucial role of miR5p on melanoma metastasis after BRAFi treatment and holds significant implying that discontinuous dosing strategy may improve the benefit of advanced BRAF(V600)-mutant melanoma patients. +circulation_biomarker_diagnosis_up 32055277 hsa-mir-155 Burkitt Lymphoma RESULTS: The expression of miR-21 and miR-155 in blood samples from patients with Burkitt's lymphoma were significantly upregulated. +circulation_biomarker_diagnosis_up 32055277 hsa-mir-21 Burkitt Lymphoma RESULTS: The expression of miR-21 and miR-155 in blood samples from patients with Burkitt's lymphoma were significantly upregulated. +other 32054948 hsa-mir-16 Lung Neoplasms In cutaneous T-cell lymphoma (CTCL) cells miR-16 regulates a switch between apoptosis and senescence, however the role of miR-34a in this process is unclear. In this work we investigate whether the coordinate action between miR-34a and miR-16 can explain experimental results in multiple cell lines of NSCLC and CTCL. +other 32054948 hsa-mir-34a Lung Neoplasms In cutaneous T-cell lymphoma (CTCL) cells miR-16 regulates a switch between apoptosis and senescence, however the role of miR-34a in this process is unclear. In this work we investigate whether the coordinate action between miR-34a and miR-16 can explain experimental results in multiple cell lines of NSCLC and CTCL. +circulation_biomarker_prognosis_ns 32054931 hsa-mir-1246 Esophageal Neoplasms The abnormal expression of serum microRNA-1246 (miR-1246) has been reported as a prognostic factor of esophageal squamous cell carcinoma (ESCC). +lncRNA target 32054840 hsa-mir-122 Fatty Liver CircRNA_002581-miRCPEB1 axis actively participates in the pathogenesis of NASH through PTEN-AMPK-mTOR pathway-related autophagy suppression. +genetics_overexpression_suppress 32054829 hsa-mir-148a Cholangiocarcinoma These results indicate that downregulation of miR-148a levels results in GLUT1 overexpression in iCCA, leading to iCCA progression and gemcitabine resistance. +lncRNA target 32054827 hsa-mir-29 Stomach Neoplasms We also revealed that MFAP2 is a novel target of microRNA-29, and miR-29/MFAP2/integrin alpha5beta1/FAK/ERK1/2 could be an important oncogenic pathway in GC progression. In conclusion, our data identified MFAP2 as a novel oncogene in GC and revealed that miR-29/MFAP2/integrin alpha5beta1/FAK/ERK1/2 could be an important oncogenic pathway in GC progression. +transcription factor target 32054528 hsa-mir-132 Osteoporosis Targeted silencing of miRNA3p expression presents a potential therapeutic target for the prevention and treatment of disuse osteoporosis. +genetics_knock down_promote 32054404 hsa-mir-26a Femur Head Necrosis Furthermore, the elevation of EZH2 could reverse the repression of SONFH progression that is induced by elevated miR-26a.We found that up-regulation of miR-26a and knockdown of EZH2 could suppress the development of SONFH, which would contribute to the therapy of SONFH. +lncRNA target 32054332 hsa-mir-873 Stomach Neoplasms 5p inhibitor or SEC11A up-regulation. +transcription factor target 32054109 hsa-mir-107 Breast Neoplasms We previously showed that high expression of the ID4 protein in triple-negative BC cells leads to the induction of a proangiogenic program in TAMs also through the downregulation of miR-107. +other 32053576 hsa-mir-34c Kidney Failure, Chronic CONCLUSIONS Therefore, CASC15 is upregulated in DCRF patients and promotes the apoptosis of podocytes by sponging miR-34c. +other 32053576 hsa-mir-34c Diabetes Mellitus CONCLUSIONS Therefore, CASC15 is upregulated in DCRF patients and promotes the apoptosis of podocytes by sponging miR-34c. +lncRNA target 32053575 hsa-mir-574 Esophageal Squamous Cell Carcinoma 5p serves as tumor promoter to promote proliferation and inhibit apoptosis of ESCC cells by targeting ZNF70 via mitochondrial-mediated ROS generation and MAPK pathways. +genetics_overexpression_promote 32053284 hsa-mir-216b Carcinoma, Hepatocellular Further studies showed that overexpression of miR-216b inhibited HCC cell growth, and molecular investigations revealed that miR-216b targeted USP28 and inhibited its expression in HCC cells. +genetics_overexpression_promote 32052927 hsa-mir-133b Urinary Bladder Neoplasms Both lnc-MST1P2 silence and miR-133b overexpression could resensitize DDP-resistant bladder cancer cells to DDP treatment. +lncRNA target 32052688 hsa-mir-625 Breast Neoplasms Furthermore, miR-625 inhibition and HMGA1 restoration both abrogated the effects of LINC00963 silencing on breast cancer cells. +lncRNA target 32052645 hsa-mir-22 hyper IgE recurrent infection syndrome 2 It was confirmed that silencing cZNF292 attenuated OGD/R-induced NSCs injury and promoted the activation of Wnt/beta-catenin and PKC/ERK pathways via the up-regulation of miR-22.Conclusions: The cZNF292 silence alleviated OGD/R-induced injury through the up-regulation of miR-22 in NSCs, and which furnished the theoretical basis for further research on HIE progression. +other 32052594 hsa-mir-339 Stomach Neoplasms RP11-81H3.2-miRHNRNPA1 interaction network regulated the GC cell proliferation, migration, and invasion. +lncRNA target 32052578 hsa-mir-370 Urinary Bladder Neoplasms 3p/FNTA/KRAS axis may lead to the development of therapies to suppress BCa metastasis and to increase its chemo-sensitivity. +transcription factor target 32052443 hsa-mir-3960 Coronary Artery Disease The expression of MMP9, CXCR1, TLR6, and MPO were significantly upregulated in CAD samples than control, and miR-3960 could bind to TLR6 to inhibit its expression. Besides, miR-3960 might function in the pathogenesis of CAD through targeting TLR6, and RELA might exert its role in CAD via targeting MMP9. +lncRNA target 32052431 hsa-mir-129 Rectal Neoplasms Meanwhile, we found E2F7 acted as a potential target of miR +exosome 32052182 hsa-mir-564 Lung Neoplasms CONCLUSION: Exosomal miR-564 and miR-658 derived from gefitinib-resistant lung cancer cells induce drug resistance in sensitive cells. +other 32052182 hsa-mir-564 Hemoglobinuria, Paroxysmal PC-9 cells transfected with miR-564 or miR-658 showed chemo-resistant phenotypes. +other 32052182 hsa-mir-658 Hemoglobinuria, Paroxysmal PC-9 cells transfected with miR-564 or miR-658 showed chemo-resistant phenotypes. +other 32052182 hsa-mir-652 Hemoglobinuria, Paroxysmal 5p were significantly upregulated in PC-9/ZD cells. +other 32052182 hsa-mir-6810 Hemoglobinuria, Paroxysmal 5p were significantly upregulated in PC-9/ZD cells. +exosome 32052182 hsa-mir-658 Lung Neoplasms CONCLUSION: Exosomal miR-564 and miR-658 derived from gefitinib-resistant lung cancer cells induce drug resistance in sensitive cells. +other 32052182 hsa-mir-126 Hemoglobinuria, Paroxysmal 5p were significantly upregulated in PC-9/ZD cells. +other 32052182 hsa-mir-3682 Hemoglobinuria, Paroxysmal 5p were significantly upregulated in PC-9/ZD cells. +genetics_overexpression_suppress 32051829 hsa-mir-127 Melanoma Overexpression of miR-127 inhibited cell proliferation and induced apoptosis in melanoma cells. +tissue_expression_up 32051753 hsa-mir-510 Colonic Neoplasms Relative levels of circ-0001313 and miRNA5p in colon cancer tissues and cell lines were determined with qRT-PCR. Regulatory effects of circ-0001313/miRNA5p/AKT2 axis on colon cancer cells were evaluated by EdU assay and flow cytometry. In conclusion, our study revealed that circ-0001313 regulates the pathogenesis of colon cancer by sponging miRNA5p to upregulate AKT2 expression. +genetics_knock down_promote 32051752 hsa-mir-34b Breast Neoplasms MiR-34b-5p functioned as a tumor suppressor by targeting ARHGAP1, and ARHGAP1 knockdown could reverse the effect of miR-34b-5p inhibitor on breast cancer cells. +transcription factor target 32051735 hsa-mir-199a Triple Negative Breast Neoplasms Conclusion: Collectively, the activation of GPER inhibits cells proliferation, invasion and EMT of triple-negative breast cancer via CD151/miR-199a-3p bio-axis. +lncRNA target 32051721 hsa-mir-135b Stomach Neoplasms Hence, inhibition of miR-135b-5p could be valuable for treatment of gastric cancer. +lncRNA target 32051698 hsa-mir-155 Stomach Neoplasms CONCLUSIONS: AFAP1-AS1 might be an oncogenic lncRNA that promoted GC progression by acting as a competing endogenous RNA (ceRNA) that regulates the expression of FGF7 through sponging miR +other 32051688 hsa-mir-1273g Hepatitis B, Chronic 2-3p for LGDH. +other 32051688 hsa-mir-4419b Hepatitis B, Chronic 2-3p for LGDH. +other 32051688 hsa-mir-129-2 Hepatitis B, Chronic 2-3p for LGDH. +other 32051688 hsa-mir-129-1 Hepatitis B, Chronic 2-3p for LGDH. +circulation_biomarker_diagnosis_ns 32051083 hsa-mir-7641 Attention Deficit Disorder with Hyperactivity The expression of miR3p and miR-7641 in serum can be used as biomarkers for the diagnosis and outcome evaluation of ADHD. +circulation_biomarker_diagnosis_ns 32050151 hsa-mir-2467 Diabetic Nephropathies Herein, we show that both of DN patients and STZ-induced type 1 diabetic rat exhibit the reduction both of urinary and circulating miR +transcription factor target 32050098 hsa-mir-126 Testicular Diseases Aberrant testicular miR3p and miR-181a expression was observed, along with decreased expression of sirtuin1 (SIRT1) and its targets; nuclear factor-erythroid 2-related factor2, haeme oxygenase-1, and superoxide dismutase2. +transcription factor target 32050098 hsa-mir-181a Testicular Diseases Aberrant testicular miR3p and miR-181a expression was observed, along with decreased expression of sirtuin1 (SIRT1) and its targets; nuclear factor-erythroid 2-related factor2, haeme oxygenase-1, and superoxide dismutase2. +circulation_biomarker_diagnosis_up 32049790 hsa-mir-206 Fetal Growth Retardation This study aimed to investigate the correlation of microRNA (miR)-206, vascular endothelial growth factor (VEGF) and miR-206/VEGF axis at different gestational ages with fetal growth retardation (FGR) risk in pregnancies.Eight hundred twenty pregnancies were consecutively recruited and their plasma samples were collected at early pregnancy (gestational age /= 28 weeks), respectively. +transcription factor target 32049548 hsa-mir-92b Inflammation miR-92b may be a novel therapeutic target for rescuing Sirt6 protein levels in intestinal epithelial cells, thereby protecting against intestinal mucosal injury caused by inflammation. +transcription factor target 32049548 hsa-mir-92b Intestinal Diseases miR-92b may be a novel therapeutic target for rescuing Sirt6 protein levels in intestinal epithelial cells, thereby protecting against intestinal mucosal injury caused by inflammation. +other 32049388 hsa-mir-15b Ovarian Neoplasms The levels of TTN-AS1, microNRA-15b-5p (miR-15b-5p), and F-box and WD repeat domain containing 7 (FBXW7) in ovarian cancer cells were measured by quantitative reverse-transcription PCR. Our results indicated that the TTN-AS1/miR-15b-5p/FBXW7 axis identified in this work could help to identify treatment biomarkers for ovarian cancer. +other 32049107 hsa-mir-1 Mouth Neoplasms The area under the ROC curve was 0.820 for miRNA-21 and 0.5 for miRNA-31, which proved that miRNA-21 is a better diagnostic marker than miRNA-31 for OPMD. +other 32049107 hsa-mir-21 Mouth Neoplasms The area under the ROC curve was 0.820 for miRNA-21 and 0.5 for miRNA-31, which proved that miRNA-21 is a better diagnostic marker than miRNA-31 for OPMD. +lncRNA target 32048816 hsa-mir-107 Insulin Resistance Importantly, miR-107 within an intron of PANK1 gene facilitated IR by targeting caveolin-1 in AML12 cells upon PA incubation. Moreover, we identify that HFD enhanced P53 expression, and activation of P53 with nutlin-3a induced PANK1 and miR-107 expression simultaneously in transcriptional level, leading to metabolic reprogramming and IR, respectively. +lncRNA target 32048816 hsa-mir-107 Metabolic Diseases In addition, the results distinguished the different roles of PANK1 and its intron miR-107 in metabolic regulation, which will provide more accurate intervention targets for the treatment of metabolic diseases. +other 32048789 hsa-mir-204 Leukemia, Myeloid, Acute MiR-204 can be used as a biomarker for PS in AML patients. +other 32048632 hsa-mir-218 Adenocarcinoma in Situ 5p may serve as a novel effective biomarker to monitor AIS progression. +other 32048611 hsa-mir-766 Carcinoma, Hepatocellular CONCLUSION: In summary, the hsa_circ_0056836 / miR3p / FOSL2 axis may serve as a promising strategy for HCC treatment. +lncRNA target 32048451 hsa-mir-149 Carcinoma, Ovarian Epithelial CONCLUSION: Circ-PVT1 enhances cell proliferation but inhibits cell apoptosis through sponging miR-149 in EOC cells, which suggests that circ-PVT1 may serve as a treatment target in EOC. +circulation_biomarker_diagnosis_down 32048448 hsa-mir-448 Tuberculosis 3p were down-regulated in plasma from patients with pulmonary TB. +circulation_biomarker_diagnosis_down 32048448 hsa-mir-223 Tuberculosis 3p were down-regulated in plasma from patients with pulmonary TB. +lncRNA target 32048402 hsa-mir-106b Sepsis HOXA-AS2 exhibited protection in sepsis-engendered AKI via targeting miR-106b-5p and hindering the Wnt/beta-catenin and NF-kappaB pathways. +lncRNA target 32048402 hsa-mir-106b Acute Kidney Injury HOXA-AS2 exhibited protection in sepsis-engendered AKI via targeting miR-106b-5p and hindering the Wnt/beta-catenin and NF-kappaB pathways. +genetics_overexpression_promote 32047668 hsa-mir-142 Cartilage Degradation 5p alleviated OA pathology by suppressing chondrocyte apoptosis, even in CXCR4 overexpressed OA chondrocytes. +transcription factor target 32047652 hsa-mir-484 Dementia In addition, we found a molecular connection between late-life depression and dementia through miR-484. +transcription factor target 32047652 hsa-mir-484 Depression In addition, we found a molecular connection between late-life depression and dementia through miR-484. +lncRNA target 32047567 hsa-mir-142 Prostatic Neoplasms 3p may be a potential target for treatment of PCa. +genetics_knock down_promote 32047553 hsa-mir-101 Urinary Bladder Neoplasms MiRNA-101 knockdown reversed the inhibitory roles of lnc00518 knockdown in proliferative, migratory and invasive potentials of bladder cancer cells. +other 32047551 hsa-mir-34c Ovarian Neoplasms When low grade serous ovarian cancers were compared with high grade serous cancers the respective miR-34 a/b/c expression was 2.6-, 40.8- and 32.3-fold higher. +genetics_GWAS 32047551 hsa-mir-34 Ovarian Neoplasms The miR-34 family expression was found to be significantly lower in type 2 in comparison to type 1 cancers (P<0.001) and in TP53-mutated compared with TP53-wild-type ovarian cancers (P<0.001, P=0.002, P=0.004, respectively). +genetics_GWAS 32047551 hsa-mir-34a Ovarian Neoplasms The miR-34 family expression was found to be significantly lower in type 2 in comparison to type 1 cancers (P<0.001) and in TP53-mutated compared with TP53-wild-type ovarian cancers (P<0.001, P=0.002, P=0.004, respectively). +other 32047549 hsa-mir-212 Ovarian Neoplasms Moreover, this study first discovered PEA15 expression in OC can be negatively regulated by microRNA212. +circulation_biomarker_diagnosis_up 32047539 hsa-mir-1290 Pancreatic Carcinoma Conclusion: Serum miR-1290 and miR-1246 might be promising biomarkers for PC diagnosis and the combined detection of CA19-9, together with miR-1290 or miR-1246, could improve the diagnostic accuracy of PC. +circulation_biomarker_diagnosis_up 32047539 hsa-mir-1246 Pancreatic Carcinoma Conclusion: Serum miR-1290 and miR-1246 might be promising biomarkers for PC diagnosis and the combined detection of CA19-9, together with miR-1290 or miR-1246, could improve the diagnostic accuracy of PC. +lncRNA target 32047516 hsa-mir-93 Urinary Bladder Neoplasms In addition, since E2F1 and E2F2 are enriched in various KEGG signaling pathways, we conclude that they are important target genes of miRNA-93, and participate in the apoptotic process by forming a complex with a certain protein or transcription factor activity, sequence-specific DNA binding in bladder cancer. +transcription factor target 32047516 hsa-mir-195 Urinary Bladder Neoplasms Functional enrichment analysis of their target mRNAs revealed that miRNA-93 and miRNA-195 may be closely related to bladder cancer by disturbing the homeostasis of the cell cycle or HTLV-I infection. +other 32047494 hsa-mir-155 osteogenesis imperfecta type 1 5p were analyzed in clinical samples from RA, other inflammatory arthritis (OIA), osteoarthritis (OA), and healthy donors (HD) by qPCR. +other 32047494 hsa-mir-221 osteogenesis imperfecta type 1 5p were analyzed in clinical samples from RA, other inflammatory arthritis (OIA), osteoarthritis (OA), and healthy donors (HD) by qPCR. +other 32047494 hsa-mir-155 Osteoarthritis 5p were analyzed in clinical samples from RA, other inflammatory arthritis (OIA), osteoarthritis (OA), and healthy donors (HD) by qPCR. +other 32047494 hsa-mir-155 Arthritis 5p were analyzed in clinical samples from RA, other inflammatory arthritis (OIA), osteoarthritis (OA), and healthy donors (HD) by qPCR. +other 32047494 hsa-mir-155 Arthritis, Rheumatoid 5p were higher in M1- than M2-macrophages derived from RA patients or HD. +other 32047494 hsa-mir-221 Osteoarthritis 5p were analyzed in clinical samples from RA, other inflammatory arthritis (OIA), osteoarthritis (OA), and healthy donors (HD) by qPCR. +lncRNA target 32047494 hsa-mir-221 Arthritis, Rheumatoid Dysregulated miR +other 32047494 hsa-mir-221 Arthritis 5p were analyzed in clinical samples from RA, other inflammatory arthritis (OIA), osteoarthritis (OA), and healthy donors (HD) by qPCR. +lncRNA target 32046858 hsa-mir-1207 Colorectal Neoplasms 5p suppressed CRC cells migration, invasion and proliferation via directly targeting of FMNL2. +lncRNA target 32046751 hsa-mir-130a Ovarian Neoplasms CONCLUSIONS: MYC, EGR1, and miR-130a-3p were hubs in our integrative analysis of ovarian CSC-enriched SFCs, suggesting that ovarian cancer SFCs display a stem cell identity with the quiescent phenotype where adhesion- and cell cycle-related genes were suppressed. +other 32046742 hsa-mir-124 Carcinoma, Renal Cell Cotransfection of miR-124 and miR-203 into 786-O cell lines effectively attenuated ZEB2 level and normalized renal cancer cell proliferation and migration. +other 32046742 hsa-mir-203 Carcinoma, Renal Cell Cotransfection of miR-124 and miR-203 into 786-O cell lines effectively attenuated ZEB2 level and normalized renal cancer cell proliferation and migration. +transcription factor target 32046740 hsa-mir-125a Carcinoma, Non-Small-Cell Lung TCTP and miR-125a-3p might act as potential prognostic biomarkers and therapeutic targets for NSCLC. +transcription factor target 32046536 hsa-mir-602 Carcinoma, Hepatocellular These results indicated that JPHY could potentially be used to treat HCC by targeting miR-602, which targets the RASSF1A gene, which in turn plays a major role in HCC pathogenesis. +genetics_overexpression_suppress 32046519 hsa-mir-497 Ovarian Neoplasms 5p is down-regulated in OC tissues, and overexpression of miR +lncRNA target 32046465 hsa-let-7a Adenomyosis These results indicated that Lin28B may be involved in the pathogenesis of adenomyosis by promoting the proliferation capacity of JZSMCs via regulating Let-7a. +genetics_overexpression_promote 32046460 hsa-mir-143 Carcinoma, Squamous Cell, Cutaneous Overexpression of miR-424 and miR-143 led to inhibited migration and invasion, while BLACAT1 overexpression led to promoted migration and invasion of CSCC cells. Therefore, BLACAT1 overexpression may promote CSCC by downregulating miR-424 and miR-143. +genetics_overexpression_promote 32046460 hsa-mir-424 cervical squamous cell carcinoma Overexpression of miR-424 and miR-143 led to inhibited migration and invasion, while BLACAT1 overexpression led to promoted migration and invasion of CSCC cells. Therefore, BLACAT1 overexpression may promote CSCC by downregulating miR-424 and miR-143. +genetics_overexpression_promote 32046460 hsa-mir-143 cervical squamous cell carcinoma Overexpression of miR-424 and miR-143 led to inhibited migration and invasion, while BLACAT1 overexpression led to promoted migration and invasion of CSCC cells. Therefore, BLACAT1 overexpression may promote CSCC by downregulating miR-424 and miR-143. +genetics_overexpression_promote 32046460 hsa-mir-424 Carcinoma, Squamous Cell, Cutaneous Overexpression of miR-424 and miR-143 led to inhibited migration and invasion, while BLACAT1 overexpression led to promoted migration and invasion of CSCC cells. Therefore, BLACAT1 overexpression may promote CSCC by downregulating miR-424 and miR-143. +transcription factor target 32046433 hsa-mir-205 Ovarian Neoplasms 3p was shown as a novel tumor suppressor in OC via inhibiting the MAPK10 pathway. +lncRNA target 32046432 hsa-mir-148 Uterine Cervical Neoplasms Our research reveals that on the one hand, bromodomain containing 7 (BRD7) acts as a transcription factor to up-regulate the expression of miR-3148 at the transcriptional level; on the other hand, miR-3148 targets the 3'UTR of Wnt3a mRNA to inhibit Wnt3a expression at the post-transcriptional level, thereby suppressing Wnt3a/beta-catenin signaling pathway and exerting its tumor suppressor role in cervical cancer. +lncRNA target 32046427 hsa-mir-612 Polycystic Ovary Syndrome Furthermore, Rap1b, a regulator of the MAPK pathway, was demonstrated to be suppressed directly by miR-612 in PCOS-IR cumulus cells based on negative expression correlation validation, dual luciferase activity assay and reduction of Rap1b expression after miR-612 mimics transfection. +other 32046419 hsa-mir-449a cervical squamous cell carcinoma FAT1 and SOX4 over-expression led to increased rates of CSCC cell migration and invasion, miR-449a over-expression led to decreased rates of CSCC cell migration and invasion and attenuated the effects of SOX4 over-expression. Therefore, FAL1 can upregulate SOX4 by downregulating miR-449a to promote the migration and invasion of CSCC cells. +genetics_knock down_promote 32046405 hsa-mir-361 Uterine Cervical Neoplasms 5p overexpression could suppress cervical cancer cell proliferation and migration, whereas promoted cell apoptosis. +other 32046402 hsa-mir-101 Human Herpesvirus 6 encephalitis The results showed that HHV-6A infection of endometrial cells up-modulates miR22 (26-fold), miR15 (19.5-fold), and miR196-5p (12.1 fold), that are correlated with implant failure, and down-modulates miR18 (11.4 fold), miR101-3p (4.6 fold), miR181-5p (4.9 fold), miR92 (3.3 fold), and miR1207-5p (3.9 fold), characterized by a low expression in preeclampsia. +other 32046402 hsa-mir-1207 Pre-Eclampsia The results showed that HHV-6A infection of endometrial cells up-modulates miR22 (26-fold), miR15 (19.5-fold), and miR196-5p (12.1 fold), that are correlated with implant failure, and down-modulates miR18 (11.4 fold), miR101-3p (4.6 fold), miR181-5p (4.9 fold), miR92 (3.3 fold), and miR1207-5p (3.9 fold), characterized by a low expression in preeclampsia. +other 32046402 hsa-mir-15 Pre-Eclampsia The results showed that HHV-6A infection of endometrial cells up-modulates miR22 (26-fold), miR15 (19.5-fold), and miR196-5p (12.1 fold), that are correlated with implant failure, and down-modulates miR18 (11.4 fold), miR101-3p (4.6 fold), miR181-5p (4.9 fold), miR92 (3.3 fold), and miR1207-5p (3.9 fold), characterized by a low expression in preeclampsia. +other 32046402 hsa-mir-1207 Human Herpesvirus 6 encephalitis The results showed that HHV-6A infection of endometrial cells up-modulates miR22 (26-fold), miR15 (19.5-fold), and miR196-5p (12.1 fold), that are correlated with implant failure, and down-modulates miR18 (11.4 fold), miR101-3p (4.6 fold), miR181-5p (4.9 fold), miR92 (3.3 fold), and miR1207-5p (3.9 fold), characterized by a low expression in preeclampsia. +other 32046402 hsa-mir-18 Human Herpesvirus 6 encephalitis The results showed that HHV-6A infection of endometrial cells up-modulates miR22 (26-fold), miR15 (19.5-fold), and miR196-5p (12.1 fold), that are correlated with implant failure, and down-modulates miR18 (11.4 fold), miR101-3p (4.6 fold), miR181-5p (4.9 fold), miR92 (3.3 fold), and miR1207-5p (3.9 fold), characterized by a low expression in preeclampsia. +other 32046402 hsa-mir-22 Pre-Eclampsia The results showed that HHV-6A infection of endometrial cells up-modulates miR22 (26-fold), miR15 (19.5-fold), and miR196-5p (12.1 fold), that are correlated with implant failure, and down-modulates miR18 (11.4 fold), miR101-3p (4.6 fold), miR181-5p (4.9 fold), miR92 (3.3 fold), and miR1207-5p (3.9 fold), characterized by a low expression in preeclampsia. +other 32046402 hsa-mir-92 Human Herpesvirus 6 encephalitis The results showed that HHV-6A infection of endometrial cells up-modulates miR22 (26-fold), miR15 (19.5-fold), and miR196-5p (12.1 fold), that are correlated with implant failure, and down-modulates miR18 (11.4 fold), miR101-3p (4.6 fold), miR181-5p (4.9 fold), miR92 (3.3 fold), and miR1207-5p (3.9 fold), characterized by a low expression in preeclampsia. +other 32046402 hsa-mir-15 Human Herpesvirus 6 encephalitis The results showed that HHV-6A infection of endometrial cells up-modulates miR22 (26-fold), miR15 (19.5-fold), and miR196-5p (12.1 fold), that are correlated with implant failure, and down-modulates miR18 (11.4 fold), miR101-3p (4.6 fold), miR181-5p (4.9 fold), miR92 (3.3 fold), and miR1207-5p (3.9 fold), characterized by a low expression in preeclampsia. +other 32046402 hsa-mir-196 Pre-Eclampsia The results showed that HHV-6A infection of endometrial cells up-modulates miR22 (26-fold), miR15 (19.5-fold), and miR196-5p (12.1 fold), that are correlated with implant failure, and down-modulates miR18 (11.4 fold), miR101-3p (4.6 fold), miR181-5p (4.9 fold), miR92 (3.3 fold), and miR1207-5p (3.9 fold), characterized by a low expression in preeclampsia. +other 32046402 hsa-mir-101 Pre-Eclampsia The results showed that HHV-6A infection of endometrial cells up-modulates miR22 (26-fold), miR15 (19.5-fold), and miR196-5p (12.1 fold), that are correlated with implant failure, and down-modulates miR18 (11.4 fold), miR101-3p (4.6 fold), miR181-5p (4.9 fold), miR92 (3.3 fold), and miR1207-5p (3.9 fold), characterized by a low expression in preeclampsia. +other 32046402 hsa-mir-18 Pre-Eclampsia The results showed that HHV-6A infection of endometrial cells up-modulates miR22 (26-fold), miR15 (19.5-fold), and miR196-5p (12.1 fold), that are correlated with implant failure, and down-modulates miR18 (11.4 fold), miR101-3p (4.6 fold), miR181-5p (4.9 fold), miR92 (3.3 fold), and miR1207-5p (3.9 fold), characterized by a low expression in preeclampsia. +other 32046402 hsa-mir-22 Human Herpesvirus 6 encephalitis The results showed that HHV-6A infection of endometrial cells up-modulates miR22 (26-fold), miR15 (19.5-fold), and miR196-5p (12.1 fold), that are correlated with implant failure, and down-modulates miR18 (11.4 fold), miR101-3p (4.6 fold), miR181-5p (4.9 fold), miR92 (3.3 fold), and miR1207-5p (3.9 fold), characterized by a low expression in preeclampsia. +other 32046402 hsa-mir-196 Human Herpesvirus 6 encephalitis The results showed that HHV-6A infection of endometrial cells up-modulates miR22 (26-fold), miR15 (19.5-fold), and miR196-5p (12.1 fold), that are correlated with implant failure, and down-modulates miR18 (11.4 fold), miR101-3p (4.6 fold), miR181-5p (4.9 fold), miR92 (3.3 fold), and miR1207-5p (3.9 fold), characterized by a low expression in preeclampsia. +other 32046402 hsa-mir-181 Pre-Eclampsia The results showed that HHV-6A infection of endometrial cells up-modulates miR22 (26-fold), miR15 (19.5-fold), and miR196-5p (12.1 fold), that are correlated with implant failure, and down-modulates miR18 (11.4 fold), miR101-3p (4.6 fold), miR181-5p (4.9 fold), miR92 (3.3 fold), and miR1207-5p (3.9 fold), characterized by a low expression in preeclampsia. +other 32046402 hsa-mir-92 Pre-Eclampsia The results showed that HHV-6A infection of endometrial cells up-modulates miR22 (26-fold), miR15 (19.5-fold), and miR196-5p (12.1 fold), that are correlated with implant failure, and down-modulates miR18 (11.4 fold), miR101-3p (4.6 fold), miR181-5p (4.9 fold), miR92 (3.3 fold), and miR1207-5p (3.9 fold), characterized by a low expression in preeclampsia. +other 32046402 hsa-mir-181 Human Herpesvirus 6 encephalitis The results showed that HHV-6A infection of endometrial cells up-modulates miR22 (26-fold), miR15 (19.5-fold), and miR196-5p (12.1 fold), that are correlated with implant failure, and down-modulates miR18 (11.4 fold), miR101-3p (4.6 fold), miR181-5p (4.9 fold), miR92 (3.3 fold), and miR1207-5p (3.9 fold), characterized by a low expression in preeclampsia. +transcription factor target 32046397 hsa-mir-93 X-linked juvenile retinoschisis 1 Collectively, these data strongly suggest that miR-93 regulates trophoblast cell proliferation, migration, invasive, and apoptosis by targeting BCL2L2 expression and is involved in the pathogenesis of RSA. +epigenetics 32046388 hsa-mir-34b Infertility The results revealed that the frequency of methylation of the promoter region of hsa-miR-34b,c in infertile men was higher than that of fertile men (82.4% versus 23.3%), and the highest frequency of methylation was observed in patients with asthenoteratospermia (92.9%) and oligoasthenoteratospermia (93.8%). In conclusion, our results indicated lower expression of hsa-miR-34a,b,c and hypermethylation of hsa-miR-34b,c promoter in sperm samples of infertile men. +other 32046388 hsa-mir-34c Infertility The highest rate of expression reduction was observed in hsa-miR-34c-5p and in oligoasthenoteratospermic patients (P = 0.011, F = 4.01). +other 32046383 hsa-mir-20a cervical squamous cell carcinoma These findings indicate that the rs9588884 GG genotype was associated with lower levels of miR-20a and eventually related to the risk of CSCC in Chinese women. +lncRNA target 32046378 hsa-mir-199a Moebius syndrome 1 Taken together, we concluded that miR-199a-5p targeted ZEB1 to inhibit the EMT of ovarian ectopic endometrial stromal cells via PI3K/Akt/mTOR signal pathway in vitro and in vivo, advancing our understanding of miR-199a-5p as regulators of Ems progression and making contribution to the treatment of Ems. +transcription factor target 32045921 hsa-mir-375 Osteoarthritis CONCLUSION: MiR-375 suppression enhanced the ability of chondrocyte to antagonize the oxidative stress and maintained the homeostasis of extracellular matrix metabolism to protect chondrocytes from OA via activation of the JAK2/STAT3 pathway, indicating that miR-375 is a potential molecular target for OA treatment. +genetics_overexpression_promote 32045359 hsa-mir-98 Migraine Disorders Overexpression of miR-98 is associated with the occurrence of MA. +other 32045334 hsa-mir-155 Polycystic Ovary Syndrome Upregulation of interleukin 6 (IL-6), phospho-STAT3 (p-STAT3), Mir-21, and Mir-155 and significant downregulation of PPAR-gamma and GLUT4 were detected in the untreated PCOS-IR rat model. In conclusion, the identification of an IL-6/p-STAT3/Mir-155/Mir-21/PPAR-gamma/GLUT4 system in the PCOS-IR rat model provides insight into the pathogenesis of PCOS and may indicate a possible therapeutic strategy. +other 32045334 hsa-mir-21 Polycystic Ovary Syndrome Upregulation of interleukin 6 (IL-6), phospho-STAT3 (p-STAT3), Mir-21, and Mir-155 and significant downregulation of PPAR-gamma and GLUT4 were detected in the untreated PCOS-IR rat model. In conclusion, the identification of an IL-6/p-STAT3/Mir-155/Mir-21/PPAR-gamma/GLUT4 system in the PCOS-IR rat model provides insight into the pathogenesis of PCOS and may indicate a possible therapeutic strategy. +other 32045135 hsa-mir-223 Colonic Neoplasms 3p on colon cancer cells was then investigated. +lncRNA target 32044957 hsa-mir-34a Colonic Neoplasms In conclusion, our findings suggest that miR-34a acts as a tumour suppressor via enhancing chemosensitivity to 5-FU in SP cells, which provides a novel therapeutic target in chemotherapy-resistant colon cancer. +lncRNA target 32044726 hsa-mir-552 Carcinoma, Hepatocellular In conclusion, our findings revealed the crucial role of the miR-552 in liver T-IC expansion and sorafenib response, rendering miR-552 an optimal target for the prevention and intervention in HCC. +lncRNA target 32044724 hsa-mir-203a Macular Degeneration Taken together, our study demonstrated that LINC00167 showed a protective role in AMD by maintaining RPE differentiation through the LINC00167/miR-203a-3p/SOCS3 axis and might be a potential therapeutic target for AMD. +circRNA target 32044717 hsa-mir-149 Stomach Neoplasms Rescue experiments indicated that circRBM33 manipulates biological function in GC cells through the circRBM33/miR-149/IL-6 axis. +transcription factor target 32043849 hsa-mir-16 Spinal Cord Injuries 5p could upregulate Apelin-13 expression to activate ERK1/2 pathway, thus alleviating SCI-induced neuron apoptosis and inflammatory response. +lncRNA target 32043754 hsa-mir-449a Hypoxia CONCLUSION: Our data suggested that circ-Ttc3 alleviated hypoxic injury and activated NF-kappaB and PI3K/AKT pathways by downregulating miR-449a in HaCaT cells. +transcription factor target 32042793 hsa-mir-1245a Colonic Neoplasms CONCLUSIONS: miR-1245a promotes the proliferation and invasion of CA by targeting BRCA2.Our results suggested that miR-1245a could be a potential biomarker for CA progression. +other 32042781 hsa-mir-107 Acute Kidney Injury Bone marrow-derived MSCs reduce miR-107 expression and increase RPS19 expression by repressing the proliferation of cisplatin-induced AKI cells and initiating apoptosis. +other 32042778 hsa-mir-465 Palatal Neoplasms Finally, we identified a NONMMUT004850.2/NONMMUT024276.2-miR3p/miR-465 ceRNA network associated with palatal shelf fusion at E14.5. +other 32042778 hsa-mir-465 Cleft Palate CONCLUSIONS: Our study demonstrated that NONMMUT004850.2/NONMMUT024276.2-miR3p/miR-465 could potentially serve as an important regulatory mechanism of palatal fusion in the development of the cleft palate. +other 32042778 hsa-mir-741 Cleft Palate CONCLUSIONS: Our study demonstrated that NONMMUT004850.2/NONMMUT024276.2-miR3p/miR-465 could potentially serve as an important regulatory mechanism of palatal fusion in the development of the cleft palate. +other 32042778 hsa-mir-741 Palatal Neoplasms Finally, we identified a NONMMUT004850.2/NONMMUT024276.2-miR3p/miR-465 ceRNA network associated with palatal shelf fusion at E14.5. +lncRNA target 32042767 hsa-mir-194 Vitreoretinopathy, Proliferative Exogenous miR-194 administration in vivo effectively suppressed PVR in the rat model, both functionally and structurally. +other 32042761 hsa-mir-23a Stomach Neoplasms We identified three interactions, hsa-miR-23a-3p-PTPN4, hsa-miR-20b-5p (hsa-miR-130a-3p)-TNFRSF10B, and hsa-miR-130a-3p (hsa-miR3p)-RAB23, that may be related to the pathogenesis of gastric adenocarcinoma. +other 32042761 hsa-mir-363 Stomach Neoplasms We identified three interactions, hsa-miR-23a-3p-PTPN4, hsa-miR-20b-5p (hsa-miR-130a-3p)-TNFRSF10B, and hsa-miR-130a-3p (hsa-miR3p)-RAB23, that may be related to the pathogenesis of gastric adenocarcinoma. +other 32042761 hsa-mir-130a Stomach Neoplasms We identified three interactions, hsa-miR-23a-3p-PTPN4, hsa-miR-20b-5p (hsa-miR-130a-3p)-TNFRSF10B, and hsa-miR-130a-3p (hsa-miR3p)-RAB23, that may be related to the pathogenesis of gastric adenocarcinoma. +other 32042761 hsa-mir-20b Stomach Neoplasms We identified three interactions, hsa-miR-23a-3p-PTPN4, hsa-miR-20b-5p (hsa-miR-130a-3p)-TNFRSF10B, and hsa-miR-130a-3p (hsa-miR3p)-RAB23, that may be related to the pathogenesis of gastric adenocarcinoma. +other 32042551 hsa-mir-632 Colorectal Neoplasms "3p/FSCN1,"" to explore the cancer-promoting mechanism of YAP1 involved in CRC." +other 32042551 hsa-mir-185 Colorectal Neoplasms "3p/FSCN1,"" to explore the cancer-promoting mechanism of YAP1 involved in CRC." +other 32042348 hsa-mir-15a Insulin Resistance RESULTS: In healthy weight IS women, both miR-15a-5p (p = 0.03) and miR5p (p < 0.01) levels were halved at 4 h post-meal. +other 32042348 hsa-mir-15a Obesity RESULTS: In healthy weight IS women, both miR-15a-5p (p = 0.03) and miR5p (p < 0.01) levels were halved at 4 h post-meal. +other 32042348 hsa-mir-17 Insulin Resistance RESULTS: In healthy weight IS women, both miR-15a-5p (p = 0.03) and miR5p (p < 0.01) levels were halved at 4 h post-meal. +other 32042348 hsa-mir-17 Obesity RESULTS: In healthy weight IS women, both miR-15a-5p (p = 0.03) and miR5p (p < 0.01) levels were halved at 4 h post-meal. +lncRNA target 32042299 hsa-mir-295 Non-alcoholic Fatty Liver Disease CONCLUSIONS: The results revealed that lncRNA Gm12664-001 attenuated hepatic lipid accumulation through negatively regulating miR +lncRNA target 32042282 hsa-mir-515 Stomach Neoplasms CONCLUSION: We established that LINC00511 may contribute to the proliferation and invasion of gastric cancer cells by modulating miR5p, indicating that LINC00511 may be a potential molecular target for the development of anti-cancer drugs. +other 32042267 hsa-mir-124 Breast Neoplasms 3p. +circulation_biomarker_diagnosis_up 32042143 hsa-mir-122 Essential Hypertension We showed that among patients with EH, the high expression of miR-122 contributed to endothelial dysfunction by suppressing the expression of the CAT-1 protein, which led to a decrease in CAT-1 expression in plasma. +genetics_overexpression_promote 32042127 hsa-mir-363 Carcinoma, Hepatocellular 3p was significantly decreased in HCC cells and overexpression of miR +circRNA target 32041942 hsa-mir-1 Squamous Cell Carcinoma of Head and Neck Furthermore, mechanistic studies showed that circ_0000140 could bind with miR-31 and up-regulate its target gene LATS2, thus affecting OSCC cellular EMT. Our findings demonstrated the roles of circ_0000140 in OSCC tumorigenesis as well as in metastasis, and circ_0000140 exerts its tumor-suppressing effect through miR-31/LATS2 axis of Hippo signaling pathway in OSCC. +lncRNA target 32041907 hsa-mir-159 Malnutrition Similar to observations in Arabidopsis, inhibition of miR159 in tobacco and rice resulted in pleiotropic defects including stunted growth, implying functional conservation of the miR159-GAMYB pathway among angiosperms. +epigenetics 32041891 hsa-mir-196b Carcinoma, Non-Small-Cell Lung Further analysis showed that hypomethylation in the promoter region enhanced miR-196b-5p expression in NSCLC. +genetics_overexpression_suppress 32041748 hsa-mir-34a Scleroderma, Systemic Consistent with these findings, we show that SSc dermal fibroblast display decreased levels of miRNA-34a in vitro. Further, EZH2 inhibition rescued miRNA-34a levels and mitigated the profibrotic phenotype of both SSc and HOTAIR overexpressing fibroblasts in vitro. +lncRNA target 32041570 hsa-mir-433 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: Our results indicated that Linc01234 promotes OSCC progression through the Linc01234/miR-433/PAK4 axis and might be a potential therapeutic target for OSCC. +other 32041551 hsa-mir-101 Stomach Neoplasms 3p PGI PGI/II was effective in distinguishing between AG and GC. +other 32041548 hsa-mir-160 Prostatic Hyperplasia 29 miRNAs, including members of miR160, miR166 and miR169 family were opposite expressed during early or late feeding stages between the two varieties, whilst 9 miRNAs were specifically expressed in BPH6G plants, suggesting involvement of these miRNAs in BPH6-mediated resistance to BPH. +other 32041548 hsa-mir-166 Prostatic Hyperplasia 29 miRNAs, including members of miR160, miR166 and miR169 family were opposite expressed during early or late feeding stages between the two varieties, whilst 9 miRNAs were specifically expressed in BPH6G plants, suggesting involvement of these miRNAs in BPH6-mediated resistance to BPH. +other 32041548 hsa-mir-169 Prostatic Hyperplasia 29 miRNAs, including members of miR160, miR166 and miR169 family were opposite expressed during early or late feeding stages between the two varieties, whilst 9 miRNAs were specifically expressed in BPH6G plants, suggesting involvement of these miRNAs in BPH6-mediated resistance to BPH. +other 32040954 hsa-mir-409 Lung Carcinoid 5p) that were shown to be downregulated in aggressive lung carcinoids. +other 32040954 hsa-mir-431 Lung Carcinoid 5p) that were shown to be downregulated in aggressive lung carcinoids. +circulation_biomarker_prognosis_ns 32040721 hsa-mir-21 Head and Neck Neoplasms In the present study, we have analyzed the expression profile of circulating miR-21, -191 and -421 in peripheral blood of head and neck cancer patients (HNC) to investigate a possible modulation of mRNA levels by radiation and to identify the role of mRNA as biomarkers of cancer prognosis. +genetics_knock down_suppress 32040593 hsa-mir-132 Lymphoma, Mantle-Cell 3p's direct target, SOX11, in MCL cell lines, and loss-function of SOX11 blocked its inhibitory effect on cell proliferation in vitro. +circulation_biomarker_diagnosis_ns 32040573 hsa-mir-622 Ovarian Neoplasms, High-Grade Serous Serum miR-622 expression is a predictive independent biomarker of response to platinum-based chemotherapy for newly diagnosed and recurrent HGSOC. +lncRNA target 32039833 hsa-mir-190b Breast Neoplasms Furthermore, we showed that TUSC8 served as a competing endogenous RNA (ceRNA) of myosin regulatory light chain interacting protein (MYLIP) through competitively binding with miR-190b-5p and suppressed breast cancer metastasis through regulating the expression of epithelial-mesenchymal transition (EMT) related markers. Taken together, these results suggested that TUSC8 inhibited breast cancer growth and metastasis via miR-190b-5p/MYLIP axis, providing us new insights into developing potential therapeutic targets for breast cancer patients. +other 32039826 hsa-mir-497 Carcinoma, Non-Small-Cell Lung JUN, IL6, CD4 and hsa-miR5p, hsa-miR-130b-5p were verified in both lung adenocarcinomas and lung squamous cell carcinomas. +other 32039826 hsa-mir-497 Pulmonary Disease, Chronic Obstructive JUN, IL6, CD4 and hsa-miR5p, hsa-miR-130b-5p were verified in both lung adenocarcinomas and lung squamous cell carcinomas. +other 32039826 hsa-mir-130b Carcinoma, Non-Small-Cell Lung JUN, IL6, CD4 and hsa-miR5p, hsa-miR-130b-5p were verified in both lung adenocarcinomas and lung squamous cell carcinomas. +other 32039826 hsa-mir-130b Pulmonary Disease, Chronic Obstructive JUN, IL6, CD4 and hsa-miR5p, hsa-miR-130b-5p were verified in both lung adenocarcinomas and lung squamous cell carcinomas. +other 32039825 hsa-mir-92a Breast Neoplasms Our data indicate that MT1JP functions as an anti-tumor LncRNA and downregulates miR3p, CD151 and CD147, and may serve as a novel diagnostic and therapeutic marker in breast cancer. +lncRNA target 32039820 hsa-mir-15a Stomach Neoplasms Silencing of lncRNA PCAT6 restrained proliferation and EMT of GC cells by targeting miR-15a via RB/E2F and Wnt/beta-catenin pathways. +circulation_biomarker_prognosis_up 32039741 hsa-mir-15b Stomach Neoplasms Therefore, serum exo-miR-15b-3p may be a potential GC diagnosis and prognosis biomarker, which can be used in precise targeted GC therapy. +circulation_biomarker_diagnosis_up 32039732 hsa-mir-129 Glioblastoma In the cytoplasm, SNHG12 served as a sponge for miR5p, leading to upregulation of MAPK1 and E2F7 and endowing the GBM cells with TMZ resistance. +other 32039711 hsa-mir-15a Aortic Aneurysm, Abdominal Moreover, circRNA/miRNA interaction networks showed that hsa_circ_0005360/miR-181b and hsa_circ_0002168/miR-15a axis might have a regulative role in human AAA. +other 32039711 hsa-mir-181b Aortic Aneurysm, Abdominal Moreover, circRNA/miRNA interaction networks showed that hsa_circ_0005360/miR-181b and hsa_circ_0002168/miR-15a axis might have a regulative role in human AAA. +other 32039495 hsa-mir-15a Multiple Myeloma Moreover, the combination miR-107 and miR-15a-5p with Hb can distinguish MM from MUGS. +other 32039495 hsa-mir-107 Multiple Myeloma Moreover, the combination miR-107 and miR-15a-5p with Hb can distinguish MM from MUGS. +lncRNA target 32039486 hsa-mir-212 Adenocarcinoma of Lung 5p may be involved in progression of NSCLC through the PI3K/Akt signaling pathway by targeting Id3. +genetics_overexpression_promote 32039426 hsa-mir-29a Carcinoma In conclusion, Se mediated miR-29a-3p overexpression induced LMH cell invasion and migration by targeting COL4A2 to inactivate the RhoA/ROCK pathway. +transcription factor target 32039213 hsa-mir-223 Inflammation Here, we explored the biological relevance of miR-125b and miR-223 altered expression during UC by identifying the potential gene targets for miR-125b and miR-223. +transcription factor target 32039213 hsa-mir-125b Inflammation Here, we explored the biological relevance of miR-125b and miR-223 altered expression during UC by identifying the potential gene targets for miR-125b and miR-223. +lncRNA target 32039029 hsa-mir-27a Carcinoma, Squamous Cell, Cutaneous Overall, these findings suggest that downregulation of miR-27a promotes tumor growth and metastasis via targeting EGFR and its downstream NF-kappaB signaling pathway, reminding that miR-27a plays a vital role in the progression of cSCC and could be a new therapeutic target. +genetics_overexpression_promote 32039003 hsa-mir-24 Carcinoma, Pancreatic Ductal 3p overexpression inhibited the proliferation of PDAC by suppressing LAMB3 expression in vivo. +genetics_overexpression_promote 32038996 hsa-mir-99a Breast Neoplasms Tumor xenograft experiment suggested miR-99a overexpression inhibited breast cancer cell proliferation in vivo. +other 32038943 hsa-mir-216a Heart Failure QRT-PCR was used to detect miR-216a between HF and healthy controls (HC). RESULTS: In this study, the results showed that miR-216a was significantly up-regulated in HF and over-expression of miR-216a promoted proliferation and enhanced the fibrogenesis in the human cardiac fibroblasts (HCF) cells. +other 32038943 hsa-mir-216a Cardiomyopathies MiR-216a decreased the expression of PTEN and SMAD7 leading to the activation of Akt/mTOR and TGF-betaRI/Smad2 in the HCF cells, which might act as a promoter of cardiac fibrosis. +other 32038723 hsa-mir-497 Colorectal Neoplasms 5p to modulate the expression of AVL9. +transcription factor target 32038705 hsa-mir-200 Squamous Cell Carcinoma of Head and Neck Members of the miR-200 family may reverse drug resistance of OSCC cells by regulating the hub genes, which can act as potential targets for the treatment of OSCC patients with cisplatin resistance. +transcription factor target 32038620 hsa-mir-1 Peste-des-Petits-Ruminants Furthermore, we found that PPRV infection induced TWEAK expression in goat NK cells involving post-transcription by suppressing miR-1, a novel negative miRNA directly targeting the TWEAK gene. Moreover, replication of virus is required for inhibition of miR-1 expression during PPRV infection, and the non-structural V protein of PPRV plays an important role in miR-1 mediated TWEAK upregulation. +exosome 32038504 hsa-mir-155 Epstein-Barr Virus Infections miR-155 was significantly elevated in EBV+ B cell lymphoma cell lines and associated exosomes and inversely correlated with expression of the miR-155 target FOXO3a in cell lines. This mechanism expands on the previously established mechanisms by which LMP1 regulates miR-155 and FOXO3a and may represent both rational therapeutic targets and biomarkers for EBV+ B cell lymphomas. +lncRNA target 32038504 hsa-mir-155 Lymphoproliferative Disorders LMP1 derived from the B95.8 lab strain or PTLD induced expression of the oncogene miR-155. Small molecule inhibitors (SMI) of p38 MAPK, NF-kappaB, and PI3K p110alpha inhibited upregulation of miR-155 by B95.8 LMP1; no individual SMI significantly reduced upregulation of miR-155 by PTLD variant LMP1. +lncRNA target 32038504 hsa-mir-155 Lymphoma This mechanism expands on the previously established mechanisms by which LMP1 regulates miR-155 and FOXO3a and may represent both rational therapeutic targets and biomarkers for EBV+ B cell lymphomas. +lncRNA target 32038504 hsa-mir-193 Lymphoproliferative Disorders However, PTLD variant LMP1 lost the ability to upregulate the tumor suppressor miR-193. +other 32038500 hsa-mir-17 Diabetes Mellitus 92 cluster may be positively related to beta-cells restoration and adaptation after streptozotocin-induced damage. +circulation_biomarker_diagnosis_up 32038235 hsa-mir-141 Leukemia, Myelogenous, Chronic, BCR-ABL Positive 5p was significantly decreased in peripheral blood cells from CML patients compared with normal blood cells and human leukemic cell line (K562 cells) compared with normal CD34(+) cells, but was remarkably elevated in patients after treatment with nilotinib or imatinib. +other 32038059 hsa-mir-9 Colorectal Neoplasms Furthermore, miR-9/NFKB1, let-7b/CCND1, let-7e/NRAS, and IGF1R played essential roles in the chemoradioresistance of CRC. +other 32038059 hsa-mir-9 Carcinoma, Non-Small-Cell Lung Furthermore, miR-9/NFKB1, let-7b/CCND1, let-7e/NRAS, and IGF1R played essential roles in the chemoradioresistance of CRC. +other 32038059 hsa-let-7e Carcinoma, Non-Small-Cell Lung Furthermore, miR-9/NFKB1, let-7b/CCND1, let-7e/NRAS, and IGF1R played essential roles in the chemoradioresistance of CRC. +other 32038059 hsa-let-7e Colorectal Neoplasms Furthermore, miR-9/NFKB1, let-7b/CCND1, let-7e/NRAS, and IGF1R played essential roles in the chemoradioresistance of CRC. +lncRNA target 32037949 hsa-mir-146b Thyroid Cancer, Papillary This study explores the hypothesis that miR-146b-5p contributes to papillary thyroid carcinogenesis through regulation of cell signaling pathways in a manner that overcomes the cellular growth suppressive events and provides survival advantage. +lncRNA target 32037864 hsa-mir-29b Osteoarthritis CONCLUSION: Downregulation of OIP5-AS1 induced by IL-1beta could inhibit the proliferation and migration abilities of CHON-001 and ATDC5 cells and facilitate the apoptosis and inflammation response via regulating miR-29b-3p/PGRN axis. +other 32037760 hsa-mir-125b Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: MicroRNA-125b is highly expressed in TSCC and associated with TNM stage, suggesting that high microRNA-125b expression may be involved in the development of TSCC. +lncRNA target 32037657 hsa-mir-382 Porcine Reproductive and Respiratory Syndrome 5p, which in turn inhibited polyI:C-induced the production of type I interferon by targeting heat shock protein 60 (HSP60), thus facilitating PRRSV replication in MARC-145 cells. +lncRNA target 32037619 hsa-mir-1322 Carcinoma, Hepatocellular Mechanistically, circ-HOMER1 enhanced the inhibition of miR-1322 on CXCL6 in HCC. Furthermore, we found that circ-HOMER1 promoted HCC cell growth and aggressiveness by miR-1322/CXCL6 axis. +genetics_knock down_promote 32037568 hsa-mir-145 Carcinoma, Hepatocellular Both the in vitro and in vivo effects of CCAT2 knockdown on the proliferation and metastasis of HCC cells were reversed by miR-145 inhibitor, indicating that miR-145 modulation accounts for CCAT2-meditated HCC progression. +other 32036213 hsa-mir-486 Heroin Use Disorder 3p was significantly increased in MA abusers compared with normal controls. +other 32036213 hsa-mir-206 Heroin Use Disorder 3p was significantly increased in MA abusers compared with normal controls. +other 32036213 hsa-let-7b Heroin Use Disorder 3p was significantly increased in MA abusers compared with normal controls. +other 32036213 hsa-mir-9 Heroin Use Disorder 3p was significantly increased in MA abusers compared with normal controls. +genetics_knock down_suppress 32036212 hsa-mir-645 Colorectal Neoplasms EFNA5 knockdown attenuated the effects of miR-645 knockdown on CRC cell migration and invasion. +circulation_biomarker_diagnosis_ns 32035607 hsa-mir-1 Asthma RESULTS: Serum miR-1 levels had inverse correlations with sputum eosinophilia, airway obstruction, and number of hospitalizations in asthmatic patients and sinonasal tissue eosinophilia in patients with CRS. +circulation_biomarker_diagnosis_ns 32035607 hsa-mir-1 Nasopharyngitis RESULTS: Serum miR-1 levels had inverse correlations with sputum eosinophilia, airway obstruction, and number of hospitalizations in asthmatic patients and sinonasal tissue eosinophilia in patients with CRS. +other 32034654 hsa-mir-141 Carcinoma, Ovarian Epithelial Taken together, our findings propose a novel model in which sEV transfer of epithelial ovarian cancer-secreted miR3p plays as a significant mediator of intercellular communication, promoting endothelial cell angiogenesis. +transcription factor target 32034643 hsa-mir-205 Plaque, Atherosclerotic 5p as a potential therapeutic target for combating unstable atherogenesis. +lncRNA target 32034483 hsa-mir-29b-1 Colorectal Neoplasms Furthermore, a reverse pattern of expression was detected between miR-29b-1 and LOC646329-variant D transcript in about 25 pairs of CRC tumor samples, detected by RTqPCR. Data also indicated that LOC646329-variant D exerts its suppression effect on CRC progression through sponging miR-29b, which in turn regulates Wnt and TGFB signaling pathways. +lncRNA target 32034483 hsa-mir-29b Colorectal Neoplasms Furthermore, a reverse pattern of expression was detected between miR-29b-1 and LOC646329-variant D transcript in about 25 pairs of CRC tumor samples, detected by RTqPCR. Data also indicated that LOC646329-variant D exerts its suppression effect on CRC progression through sponging miR-29b, which in turn regulates Wnt and TGFB signaling pathways. +lncRNA target 32034251 hsa-mir-141 Microphthalmos Moreover, both miR3p and miR-200a-3p showed direct targeting of microphthalmia-associated transcription factor using a luciferase reporter assay. +lncRNA target 32034251 hsa-mir-200a Microphthalmos Moreover, both miR3p and miR-200a-3p showed direct targeting of microphthalmia-associated transcription factor using a luciferase reporter assay. +other 32033981 hsa-mir-155 Neurogenic Inflammation Besides confirming the association of miR-146a-5p/150-5p/155-5p with MS, 7 miRNAs uncharacterized for MS emerged (miR-15a-3p/124-5p/149-3p/29c-3p/33a-3p/34c-5p/297 PCA showed that distinct miRNA sets segregated MS from controls and relapse from remission. +other 32033981 hsa-mir-155 Multiple Sclerosis Besides confirming the association of miR-146a-5p/150-5p/155-5p with MS, 7 miRNAs uncharacterized for MS emerged (miR-15a-3p/124-5p/149-3p/29c-3p/33a-3p/34c-5p/297 PCA showed that distinct miRNA sets segregated MS from controls and relapse from remission. +other 32033981 hsa-mir-146a Multiple Sclerosis Besides confirming the association of miR-146a-5p/150-5p/155-5p with MS, 7 miRNAs uncharacterized for MS emerged (miR-15a-3p/124-5p/149-3p/29c-3p/33a-3p/34c-5p/297 PCA showed that distinct miRNA sets segregated MS from controls and relapse from remission. +other 32033981 hsa-mir-146a Neurogenic Inflammation Besides confirming the association of miR-146a-5p/150-5p/155-5p with MS, 7 miRNAs uncharacterized for MS emerged (miR-15a-3p/124-5p/149-3p/29c-3p/33a-3p/34c-5p/297 PCA showed that distinct miRNA sets segregated MS from controls and relapse from remission. +other 32033981 hsa-mir-150 Multiple Sclerosis Besides confirming the association of miR-146a-5p/150-5p/155-5p with MS, 7 miRNAs uncharacterized for MS emerged (miR-15a-3p/124-5p/149-3p/29c-3p/33a-3p/34c-5p/297 PCA showed that distinct miRNA sets segregated MS from controls and relapse from remission. +other 32033981 hsa-mir-150 Neurogenic Inflammation Besides confirming the association of miR-146a-5p/150-5p/155-5p with MS, 7 miRNAs uncharacterized for MS emerged (miR-15a-3p/124-5p/149-3p/29c-3p/33a-3p/34c-5p/297 PCA showed that distinct miRNA sets segregated MS from controls and relapse from remission. +circulation_biomarker_diagnosis_up 32033332 hsa-mir-133b Coronary Artery Disease MiR-133b was downregulated by 4.6 fold (p < 0.0001) whereas miR-21 was upregulated by ~2 fold (p < 0.0001) in plasma samples of CAD patients. Our results suggest that miR-133b and miR-21 could be possible candidates of novel biomarkers in early prediction of CAD. +circulation_biomarker_diagnosis_up 32033332 hsa-mir-21 Coronary Artery Disease MiR-133b was downregulated by 4.6 fold (p < 0.0001) whereas miR-21 was upregulated by ~2 fold (p < 0.0001) in plasma samples of CAD patients. Our results suggest that miR-133b and miR-21 could be possible candidates of novel biomarkers in early prediction of CAD. +genetics_knock down_promote 32032908 hsa-mir-182 Glioma Moreover, FBXW7 knockdown could reverse the inhibitory effect of miR-182 inhibitor on glioma cells. +genetics_overexpression_promote 32032888 hsa-mir-23a Squamous Cell Carcinoma of Head and Neck In addition, the tumor radiosensitivity-promoting effect of circATRNL1 overexpression was blocked by miR-23a-3p in OSCC. +lncRNA target 32032565 hsa-mir-193b Reperfusion Injury Neurological deficit scores, infarct volumes and neuronal injury were alleviated by miR-193b-3p agomir treatment but aggravated by miR-193b-3p antagomir. +lncRNA target 32032565 hsa-mir-193b Brain Ischemia Neurological deficit scores, infarct volumes and neuronal injury were alleviated by miR-193b-3p agomir treatment but aggravated by miR-193b-3p antagomir. +transcription factor target 32031986 hsa-mir-149 Familial Primary Pulmonary Hypertension This means minor allele T of rs3740297 could significantly decrease susceptibility of IPAH in Chinese population, possibly by increasing BMP9 expression through losing a miR-149 binding site. +other 32031966 hsa-mir-200a Diabetes Mellitus The present study has investigated the effect of microRNA-200a (miR-200a) on NRF2 signaling and diabetic ED. Therefore, the present study has uncovered miR-200a/KEAP1/NRF2 signaling that controls aortic endothelial antioxidant capacity, which protects against diabetic ED. +genetics_GWAS 32031872 hsa-mir-146a Carcinoma, Hepatocellular Many recent studies have assessed the relationship between miRNA-499, miRNA-146a, and miRNA-196a2 loci and HCC risk. +lncRNA target 32031750 hsa-mir-126 Colorectal Neoplasms Downregulated CRNDE aggravates hepatic injury via regulating miR +lncRNA target 32031750 hsa-mir-126 Sepsis Downregulated CRNDE aggravates hepatic injury via regulating miR +lncRNA target 32031750 hsa-mir-126 Liver Injury Downregulated CRNDE aggravates hepatic injury via regulating miR +transcription factor target 32031354 hsa-mir-675 Intervertebral Disc Degeneration 3p may control nucleus pulposus (NP) cell apoptosis through the MAPK signaling pathway in IDD patients. +other 32031069 hsa-mir-582 Neurotoxicity Syndromes METHODS: In this study, primary rat hippocampal neurons were used to investigate the role of miR- 582-5p in propofol-induced neurotoxicity. +lncRNA target 32031046 hsa-mir-182 Colorectal Neoplasms Further research proved that lnc-AGER-1 altered the expression of its neighbor gene, AGER, through acting as a competing endogenous RNA for miR-182 in colorectal cancer. +lncRNA target 32030886 hsa-mir-24-2 Liver Neoplasms This study elucidates a novel mechanism for miR24-2 in liver cancer and suggests that miR24-2 may be used as novel therapeutic targets of liver cancer. +lncRNA target 32030826 hsa-mir-34a Osteoarthritis It is known that miR-34a can promote the apoptosis of chondrocytes, which directly contribute to osteoarthritis (OA). We found that LUADT1 was downregulated, while miR-34a was upregulated in OA synovial fluid. +transcription factor target 32030815 hsa-mir-1 Myocardial Ischemia Taken together, our data suggested that miR-1 promoted hypoxia-induced injury by targeting NOTCH3, indicating novel therapeutic targets for treatment of myocardial ischemia injury. +other 32030815 hsa-mir-1 Heart Injuries In this study, we investigated the potential roles of miR-1 in cell proliferation, apoptosis, and autophagy in hypoxia-treated cardiac injury and explored the underlying mechanism using H9c2 cells. +genetics_knock down_promote 32030815 hsa-mir-1 Hypoxia Moreover, overexpression of miR-1 promoted cell apoptosis and inhibited cell proliferation and autophagy in H9c2 cells treated with hypoxia, while its knockdown played an opposite effect. +other 32030798 hsa-mir-4485 Asthenozoospermia 3p was associated with idiopathic AZS, which could be a molecular link between mitochondrial dysfunction and AZS. +circulation_biomarker_prognosis_ns 32030736 hsa-mir-193a Multiple Myeloma Conclusively, expression of circulating miR-193a-5p before ASCT could be a prognostic biomarker for transplant-eligible MM. +lncRNA target 32030273 hsa-mir-342 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: Collectively, these findings suggest that the upregulation of miR3p contributes to gefitinib resistance by targeting CPA4, which may serve as a potential treatment option to overcome gefitinib resistance in patients with NSCLC. +circulation_biomarker_prognosis_ns 32029031 hsa-mir-494 Acute Kidney Injury ROC curve analysis showed the area under the curve (AUC) to predict the death of children with postoperative AKI was 0.868, 0.857 and 0.819 respectively, AUC of serum miR-494, NGAL and KIM-1 levels combination to predict the death of children with postoperative AKI was the largest (0.964, 95%CI was 0.908-0.997), with a high sensitivity and specificity of 97.0% and 91.8%. +transcription factor target 32028978 hsa-mir-200b Nasopharyngeal Neoplasms CONCLUSIONS: Our findings indicate that PinX1 inhibits cell proliferation, migration, and invasion via P53/miR-200b-regulated EMT in the malignant progression of human NPC, which might suggest novel clinical implications for disease treatment. +lncRNA target 32028854 hsa-mir-218 Diabetic Nephropathies The purpose of this study was to explore the functional implication of microRNA-218 (miR-218) in diabetic nephropathy (DN) through high-glucose-stimulated renal proximal tubule impairment. +lncRNA target 32028854 hsa-mir-218 Fanconi Syndrome The purpose of this study was to explore the functional implication of microRNA-218 (miR-218) in diabetic nephropathy (DN) through high-glucose-stimulated renal proximal tubule impairment. +lncRNA target 32028854 hsa-mir-218 Norrie disease The purpose of this study was to explore the functional implication of microRNA-218 (miR-218) in diabetic nephropathy (DN) through high-glucose-stimulated renal proximal tubule impairment. Accordingly, these data indicated that downregulation of miR-218 can assuage high-glucose-resulted renal tubular cell damage, and its ameliorative effect was achieved by negative regulation of GPRC5A, which provides a novel direction for unearthing the pathogenesis and even further biological treatment of DN. +other 32028704 hsa-mir-28 Prostatic Neoplasms Here, we demonstrate that miR5p acts as a TS in prostate cancer (PCa) cells affecting cell proliferation/survival, as well as migration and invasion. +other 32028703 hsa-mir-10b Colorectal Neoplasms There were five potential candidate miRNAs (miRNA5p, miRNA-10b-5, miRNA-30e-5p, miRNA-21 and miRNA-30e) were confirmed as CRC diagnostic biomarkers, and two of them (miRNA-21 and miRNA-30e) were previously reported. +other 32028703 hsa-mir-186 Colorectal Neoplasms There were five potential candidate miRNAs (miRNA5p, miRNA-10b-5, miRNA-30e-5p, miRNA-21 and miRNA-30e) were confirmed as CRC diagnostic biomarkers, and two of them (miRNA-21 and miRNA-30e) were previously reported. +other 32028703 hsa-mir-21 Colorectal Neoplasms There were five potential candidate miRNAs (miRNA5p, miRNA-10b-5, miRNA-30e-5p, miRNA-21 and miRNA-30e) were confirmed as CRC diagnostic biomarkers, and two of them (miRNA-21 and miRNA-30e) were previously reported. +circulation_biomarker_diagnosis_ns 32028672 hsa-mir-23a Sleep Apnea, Obstructive Gene expression levels of the miR-21/23a, and their predicted target genes were assessed in peripheral blood mononuclear cells from 40 treatment-naive severe OSA patients, and 20 matched subjects with primary snoring (PS). +other 32028672 hsa-mir-23 Sleep Apnea, Obstructive 3p gene expressions were decreased in OSA patients as compared with that in PS subjects, while TNF-alpha gene expression was increased. +circulation_biomarker_diagnosis_ns 32028672 hsa-mir-21 Sleep Apnea, Obstructive Gene expression levels of the miR-21/23a, and their predicted target genes were assessed in peripheral blood mononuclear cells from 40 treatment-naive severe OSA patients, and 20 matched subjects with primary snoring (PS). +transcription factor target 32028542 hsa-mir-148 Osteoarthritis CONCLUSIONS: Our present findings highlight a protective effect of OLA on IL-1beta-induced chondrocyte dysfunction, and a novel signal cascade comprising the miR3p/FGF2 signaling pathway might be a potential therapeutic target of OLA with respect to preventing the progression of osteoarthritis. +other 32027760 hsa-mir-145 Chondrosarcoma Our findings underscore miR-143/145/FSCN1 as important players in chondrosarcoma and may potentially open new avenues for specific therapeutic intervention options. +other 32027270 hsa-mir-195 Lymphoma, Large B-Cell, Diffuse DLBCL patients with higher expression of miR-195 show longer overall survival time. +genetics_knock down_promote 32027263 hsa-mir-429 Precursor Cell Lymphoblastic Leukemia-Lymphoma Univariate Cox regression analysis showed that leukocyte level, ratio of bone marrow primordial cells, Hb and LDH level, risk grading and miR-429 were the factors influencing overall survival rate in ALL patients (P<0.05). +transcription factor target 32027261 hsa-mir-145 Leukemia CONCLUSION: Upregulation of miRNA-145 may inhibit the proliferation of leukemia cells and promote the apoptosis, which may be related with the inhibition of PI3K/AKT signaling pathway. +genetics_GWAS 32027250 hsa-mir-155 Leukemia, Lymphocytic, Chronic, B-Cell The expression of miR-155 in CLL patients was compared with the healthy controls, and the correlation of miR-155 expression with the clinical characteristics of CLL patients such as age, sex, Binet stage, cytogenetic and molecular genetic, as well as the relationship of miR-155 expression level with time to treatment (TTT) and overall survival (OS) was further analysed. +other 32027093 hsa-mir-636 Prostatic Neoplasms miR-636, a novel oncogene, was found to be up-regulated in bone metastatic PCa tissues and also predominately up-regulated in human PCa cell lines. +lncRNA target 32027089 hsa-mir-197 Fibrosarcoma 3p significantly inhibits viability, colony forming, and migration ability as well as triggers G2/M phase cell cycle arrest and autophagy in fibrosarcoma cells. +transcription factor target 32027086 hsa-mir-16 Carcinoma, Non-Small-Cell Lung CONCLUSION: In conclusion, quercetin enhanced the radiosensitivity of NSCLC cells via modulating the expression of miR5p and WEE1. +lncRNA target 32026628 hsa-mir-1 Hyperglycemia Human retinal microvascular endothelial cells (HRECs) were exposed to 5 mmol/L (normoglycemia; NG) or 25 mmol/L glucose (hyperglycemia; HG) with or without transfection of miRNA antagomirs (miRNA-1, miRNA-19b, and miRNA-320; specific SIRT-targeting miRNAs). +lncRNA target 32026628 hsa-mir-19b Hyperglycemia Human retinal microvascular endothelial cells (HRECs) were exposed to 5 mmol/L (normoglycemia; NG) or 25 mmol/L glucose (hyperglycemia; HG) with or without transfection of miRNA antagomirs (miRNA-1, miRNA-19b, and miRNA-320; specific SIRT-targeting miRNAs). +lncRNA target 32026628 hsa-mir-20 Hyperglycemia Human retinal microvascular endothelial cells (HRECs) were exposed to 5 mmol/L (normoglycemia; NG) or 25 mmol/L glucose (hyperglycemia; HG) with or without transfection of miRNA antagomirs (miRNA-1, miRNA-19b, and miRNA-320; specific SIRT-targeting miRNAs). +lncRNA target 32026479 hsa-mir-7 Glioblastoma KEY FINDINGS: Our data showed that miRNA-7 markedly inhibited the expression of IRS-1 and IRS-2 in a time-dependent manner, inhibited the proliferation of glioblastoma cells and enhanced apoptosis (P < 0.05, relative to control). +circRNA target 32026471 hsa-mir-942 Stomach Neoplasms 5p; thus, inhibiting GC proliferation and invasion. +circulation_biomarker_diagnosis_ns 32026462 hsa-mir-1260b Adenocarcinoma of Lung Elevated expression of miR-1260b in LAC tissues was positively correlated with exosomal-miR-1260b in plasma (r = .642, p < .05). +circulation_biomarker_diagnosis_up 32025863 hsa-mir-128 Depression CONCLUSIONS: Patients with type 2 diabetes and depression exhibited increased circulatory levels of miR-128 and serum cortisol and decreased levels of BDNF and shortened telomeres. +circulation_biomarker_diagnosis_up 32025863 hsa-mir-128 Diabetes Mellitus, Type 2 CONCLUSIONS: Patients with type 2 diabetes and depression exhibited increased circulatory levels of miR-128 and serum cortisol and decreased levels of BDNF and shortened telomeres. +lncRNA target 32025520 hsa-mir-125b Uterine Cervical Neoplasms In addition, our study also suggests that intervention of CAR10/miR-125b-5p/PDPK1 network may be a new strategy for targeted therapy of cervical cancer. +other 32025275 hsa-mir-200b Ovarian Neoplasms CONCLUSIONS: miR-200c, miR-200a, and miR-200b can be useful diagnostic biomarkers for ovarian cancer. +other 32025275 hsa-mir-200c Ovarian Neoplasms CONCLUSIONS: miR-200c, miR-200a, and miR-200b can be useful diagnostic biomarkers for ovarian cancer. +other 32025275 hsa-mir-200a Ovarian Neoplasms CONCLUSIONS: miR-200c, miR-200a, and miR-200b can be useful diagnostic biomarkers for ovarian cancer. +genetics_knock down_promote 32025219 hsa-mir-342 Multiple Myeloma 3p could rescue the effect of SNHG16 knockdown on MM cell proliferation, cycle arrest, apoptosis, and related protein expression. +lncRNA target 32025213 hsa-mir-137 Femur Head Necrosis 3p directly targets the genes, Runx2 and CXCL12, which can play critical roles in SONFH repair by facilitating osteogenic differentiation and mobilizing EPCs. +transcription factor target 32025209 hsa-mir-153 Triple Negative Breast Neoplasms We recently reported that mifepristone (MIF), a drug regularly used for abortion, suppresses TNBC cell growth by inhibiting KLF5 expression via inducing miR-153. +genetics_GWAS 32024878 hsa-mir-16 Leukemia, Myeloid In accordance with these results, miR-16 expression was significantly reduced in a panel of AML primary samples carrying the FLT3-ITD mutation when compared with FLT3wt cells. +lncRNA target 32024815 hsa-mir-632 Carcinoma, Hepatocellular Mechanistically, RUNX1-IT1 directly bound to miR-632 and acted as competing endogenous RNA to facilitate the expression of the miR-632 target gene GSK-3beta and subsequently modulate the WNT/beta-catenin pathway in HCC cells. +genetics_knock down_promote 32024814 hsa-mir-210 Osteosarcoma 5p overexpression promoted OS tumor growth and pulmonary metastasis. +circulation_biomarker_diagnosis_up 32024541 hsa-mir-876 Enterovirus Infections 5p) is a circulating miRNA that can be identified to modulate EV-A71 infections through both in vitro and in vivo studies. +genetics_knock down_promote 32024541 hsa-mir-876 Epidermodysplasia Verruciformis Overexpression of miR +genetics_overexpression_promote 32024457 hsa-mir-188 Glioma 3p inhibitor on cell behaviors was further strengthened by the overexpression of GPR26 in GBM.Conclusion: These findings provided evidence for the cancer-promoting effect of miR +other 32024063 hsa-mir-29c Carcinoma, Pancreatic Ductal Master regulatory analysis revealed that the particular subtype of PDAC is predominantly influenced by miR-29c and miR-192. +other 32024063 hsa-mir-192 Carcinoma, Pancreatic Ductal Master regulatory analysis revealed that the particular subtype of PDAC is predominantly influenced by miR-29c and miR-192. +lncRNA target 32023766 hsa-mir-513a Stomach Neoplasms Conclusion: miR-513a-3p may inhibit the proliferation, migration and invasion of gastric cancer cells through targeting regulation of MDM2, which will provide new targets for the prevention and treatment of gastric cancer. +circRNA target 32023551 hsa-mir-23a Cardiomegaly Finally, we identified that ANF and miR-23a are downstream targets of circRNA wwp1, suggesting that circRNA wwp1 exerts inhibitory roles of cardiac hypertrophy via down-regulation of ANF and miR-23a, which underlying the potential mechanisms whereby circRNA regulates cardiac hypertrophy. +transcription factor target 32023549 hsa-mir-96 Fatty Liver 5p was able to suppress p66shc/cytochrome C cascade via targeting p66shc mRNA 3'UTR, and catalpol could lead to suppression of NAFLD via upregulating miR +genetics_overexpression_suppress 32023352 hsa-mir-511 Breast Neoplasms It was also confirmed that miR-511 directly targeted 3'-UTR of FGF4 and reduced its expression, and FGF4 overexpression reversed the effect of miR-511 on the malignant phenotypes of breast cancer cells. +circRNA target 32023009 hsa-mir-760 Ovarian Neoplasms In summary, the data suggest that hsa_circ_0007874 acts as a tumor suppressor by regulating the miR-760/SOCS3 axis, highlighting its potential as an effective therapeutic target for OVA. +transcription factor target 32022984 hsa-mir-128 Melanoma Taken together, these results showed that gypenoside LI could inhibit human melanoma cells through inducing apoptosis, arresting cell cycle at the S phase and suppressing the Wnt/beta-catenin signaling pathway in a miR +lncRNA target 32022476 hsa-mir-422a Carcinoma, Hepatocellular CONCLUSIONS: DUXAP8 was a sponge of tumor suppressor miR-422a in HCC, enhanced the expression of PDK2 indirectly, and functioned as an oncogenic lncRNA. +epigenetics 32022461 hsa-mir-124-2 Squamous Intraepithelial Lesions, Cervical Additional potential markers include methylation of tumor suppressor genes FAM19A4/miR124-2 in cervical cytology for advanced transforming HSIL and the IHC marker HPV E4 for productive, potentially regressing lesions. +genetics_overexpression_promote 32022430 hsa-mir-660 Lung Neoplasms 5p, SMARCA5 overexpression in vitro suppressed tumor progression and osteolytic metastasis associated RANKL signaling, which is congruent with the effect of nm23-H1 on the lung cancer cells. +transcription factor target 32021975 hsa-mir-135a Endometrial Neoplasms CONCLUSION: MiR-135a played important roles in tumorigenesis and disease progression of endometrial cancer by regulating proliferation and chemosensitivy of endometrial cancer cells by targeting AKT signaling pathway. +other 32021962 hsa-mir-223 Stomach Neoplasms 3p) were significantly upregulated in 12 PM (+) samples, and their expression levels showed positive correlation with peritoneal cancer index. +other 32021962 hsa-mir-92a Stomach Neoplasms 3p) were significantly upregulated in 12 PM (+) samples, and their expression levels showed positive correlation with peritoneal cancer index. +other 32021962 hsa-mir-21 Peritoneal Neoplasms 3p) were significantly upregulated in 12 PM (+) samples, and their expression levels showed positive correlation with peritoneal cancer index. +other 32021962 hsa-mir-223 Peritoneal Neoplasms 3p) were significantly upregulated in 12 PM (+) samples, and their expression levels showed positive correlation with peritoneal cancer index. +other 32021962 hsa-mir-21 Stomach Neoplasms 3p) were significantly upregulated in 12 PM (+) samples, and their expression levels showed positive correlation with peritoneal cancer index. +other 32021962 hsa-mir-29 Stomach Neoplasms In contrast, miR-29 family were all downregulated in patients with PM (+) samples. +other 32021962 hsa-mir-29 Peritoneal Neoplasms In contrast, miR-29 family were all downregulated in patients with PM (+) samples. +other 32021962 hsa-mir-342 Stomach Neoplasms 3p) were significantly upregulated in 12 PM (+) samples, and their expression levels showed positive correlation with peritoneal cancer index. +other 32021962 hsa-mir-92a Peritoneal Neoplasms 3p) were significantly upregulated in 12 PM (+) samples, and their expression levels showed positive correlation with peritoneal cancer index. +other 32021962 hsa-mir-342 Peritoneal Neoplasms 3p) were significantly upregulated in 12 PM (+) samples, and their expression levels showed positive correlation with peritoneal cancer index. +other 32021906 hsa-mir-155 Bone Neoplasms We show that forced expression of miR-155 in tumor antigen-specific T cells improves the tumor control of B16 tumors expressing a low-affinity antigen ligand. +circulation_biomarker_diagnosis_up 32021461 hsa-mir-486 Carcinoma, Non-Small-Cell Lung 5p were 0.813 and 0.886, respectively, and higher than that of the 4 serum miRNAs. +circulation_biomarker_diagnosis_up 32021461 hsa-mir-222 Carcinoma, Non-Small-Cell Lung 5p, and 2 serum exosomal miRNAs including miR-146a-5p and miR +circulation_biomarker_diagnosis_ns 32021461 hsa-mir-126 Carcinoma, Non-Small-Cell Lung METHODS: We measured 8 serum miRNAs and the corresponding serum exosomal miRNAs including miR +circulation_biomarker_diagnosis_up 32021461 hsa-mir-146a Carcinoma, Non-Small-Cell Lung 5p were 0.813 and 0.886, respectively, and higher than that of the 4 serum miRNAs. +circulation_biomarker_diagnosis_up 32021461 hsa-mir-21 Carcinoma, Non-Small-Cell Lung 5p, and 2 serum exosomal miRNAs including miR-146a-5p and miR +circulation_biomarker_diagnosis_up 32021461 hsa-mir-141 Carcinoma, Non-Small-Cell Lung 5p, and 2 serum exosomal miRNAs including miR-146a-5p and miR +lncRNA target 32021459 hsa-mir-378 Ovarian Neoplasms CONCLUSION: On the whole, our results demonstrate an explicit oncogenic role of LINC00963 in ovarian cancer tumorigenesis via competition with miR-378g, suggesting a new regulatory mechanism of LINC00963 and providing a potential therapeutic target for ovarian cancer patients. +genetics_overexpression_promote 32021456 hsa-mir-203 Thyroid Cancer, Papillary Cell proliferation assay showed that overexpression of WT1-AS and miR-203 led to decreased, while survivin overexpression led to increased proliferation of PTC cells. +lncRNA target 32021443 hsa-mir-374a Carcinoma, Non-Small-Cell Lung CONCLUSION: In conclusion, lncRNA MAGI2-AS3 suppressed LUSC by regulating miR-374a/b-5p/CADM2 axis, which might potentially serve as a therapeutic marker for LUSC patients. +lncRNA target 32021443 hsa-mir-374b Carcinoma, Non-Small-Cell Lung CONCLUSION: In conclusion, lncRNA MAGI2-AS3 suppressed LUSC by regulating miR-374a/b-5p/CADM2 axis, which might potentially serve as a therapeutic marker for LUSC patients. +lncRNA target 32021442 hsa-mir-423 Squamous Cell Carcinoma of Head and Neck The miR5p inhibitor can rescue the carcinogenesis effect of CASC9 on TSCC cells. +lncRNA target 32021436 hsa-mir-539 Thyroid Cancer, Papillary CONCLUSION: These findings indicated that LINC00460 can modulate MMP-9 expression to promote cell proliferation, invasion and apoptosis through targeting miR-539, suggesting act as an oncogenic RNA in PTC and provide a new therapeutic perspective. +lncRNA target 32021434 hsa-mir-338 Uterine Cervical Neoplasms Therefore, targeting circ-HIPK3/miR +circulation_biomarker_prognosis_up 32021418 hsa-mir-21 Esophageal Squamous Cell Carcinoma RESULTS: The expression level of miRNA-21 and SNHG1 are significantly upregulated in tissues, serum and cell lines of ESCC, and tissue miRNA-21 and SNHG1 significantly correlates with lymph node metastasis, TNM stage, tumor size, and poor overall survival in ESCC patients. +genetics_knock down_suppress 32021307 hsa-mir-381 Breast Neoplasms The functional roles of SNHG15 and miR-381 in breast cancer were determined using MTT assay and flow cytometry analysis. CONCLUSION: In summary, SNHG15 knockdown overcame cisplatin resistance of breast cancer by sponging miR-381, providing a novel therapeutic target for breast cancer. +transcription factor target 32021304 hsa-mir-365 Breast Neoplasms TargetScan was used to predict up-stream of FOXK1, indicating that miR +genetics_overexpression_promote 32021301 hsa-mir-100 Nasopharyngeal Carcinoma Overexpression of miR-100 obviously suppressed NPC cell growth and proliferation, whereas silencing miR-100 promoted NPC cell growth and proliferation in vitro. +other 32021299 hsa-mir-204 Ovarian Neoplasms In addition, luciferase activity suggested that lncRNA-ATB negatively regulated miR3p in ovarian cancer. +lncRNA target 32021298 hsa-mir-22 Stomach Neoplasms CONCLUSION: Silencing of MALAT1 inhibited the proliferation and promoted the apoptosis of GC cells through upregulating miR +genetics_overexpression_suppress 32021297 hsa-mir-188 Carcinoma, Non-Small-Cell Lung 3p overexpression inhibited it by CCK8 and colony formation analysis. +lncRNA target 32021286 hsa-mir-184 Carcinoma, Hepatocellular Cell function assay and Western blot showed SNHG4/miR-184/AGO2 regulatory loop was critical for HCC cell proliferation, migration, apoptosis, and autophagy. CONCLUSION: Our study demonstrated that the expression of SNHG11 is higher in HCC; moreover, SNHG11 promotes proliferation, migration, apoptosis, and autophagy by regulating AGO2 via miR-184 in HCC. +genetics_overexpression_promote 32021284 hsa-mir-939 Pancreatic Carcinoma However, ARHGAP4 overexpression markedly inhibited the increased viability, migration, and invasion induced by miR +genetics_overexpression_promote 32021281 hsa-mir-206 Glioma Besides that, we also found overexpressed miR-206 enhanced propofol-mediated inhibition on the migration, invasion, and PI3K/AKT pathway activation of glioma cells. +genetics_knock down_promote 32021273 hsa-mir-542 Neuroblastoma 3p knockdown. +genetics_overexpression_suppress 32021271 hsa-mir-194 Squamous Cell Carcinoma of Head and Neck 5p overexpression reversed PVT1-induced promotion of OSCC cell proliferation and cisplatin resistance. +lncRNA target 32021269 hsa-mir-708 Uterine Cervical Neoplasms CONCLUSION: We conclude that miR-708 suppresses cell proliferation, facilitates cisplatin efficacy, and impairs DNA repair pathway in cervical cancer cells. +genetics_overexpression_promote 32021265 hsa-mir-345 Carcinoma, Hepatocellular 5p overexpression sensitized HCC cells to radiation. +transcription factor target 32021259 hsa-mir-1269b Carcinoma, Non-Small-Cell Lung CONCLUSION: In conclusion, these findings suggest that the miR-1269b/PTEN/PI3K/AKT-mediated network might promote cisplatin resistance in NSCLC, and that miR-1269b can be a potential therapeutic target for chemoresistance in NSCLC patients. +other 32021248 hsa-mir-144 Stomach Neoplasms CONCLUSION: In summary, the above results support a model in which the FTX/miR-144/ZFX act as important effectors in GC tumorigenesis and progression, indicating new therapeutic methods in GC. +genetics_overexpression_promote 32021247 hsa-mir-520b Breast Neoplasms miR-520b positively regulates Hippo/YAP signaling pathway and overexpression of LAST2 abolished the effect of miR-520b on the stemness of breast cancer cells. +transcription factor target 32021245 hsa-mir-375 Osteosarcoma Moreover, Mcl-1 was found to be a direct target of miR-375 in OS cells. CONCLUSION: Our data indicated that chemotherapy-driven increase in the expression of Mcl-1 plays a critical role in chemoresistance, and the intervention of the miR-375/Mcl-1 axis may offer a novel strategy to enhance chemosensitivity in OS treatment. +lncRNA target 32021239 hsa-mir-26a Osteosarcoma CONCLUSION: These findings indicate that highly expressed miR-26a-5p in osteosarcoma cells, and promotes proliferation and migration, but inhibits apoptosis of osteosarcoma cells by targeting HOXA5 which suggest that miR-26a-5p could serve as a novel therapeutic target for osteosarcoma. +other 32020849 hsa-mir-376c Osteosarcoma Both in osteosarcoma tissues and Saos-2 cells, miR-376c expression was significantly decreased and TGFA mRNA expression was significantly increased compared with control. +other 32020730 hsa-mir-377 Colorectal Neoplasms CircPRTM5 exerts critical regulatory role in CRC progression by sponging miR-377 to induce E2F3 expression. +circRNA target 32020707 hsa-mir-21 Stomach Neoplasms Mechanistically, miR-21 expression was upregulated in GC tissues and could be negatively regulated by circHIAT1. CircHIAT1 functioned as a tumor inhibitor in GC cells through downregulating miR-21, and could be a novel target for GC treatment. +genetics_knock down_promote 32020591 hsa-mir-106a Carcinoma, Hepatocellular Mechanistically, TCL6 knockdown evidently reduced PTEN expression at both messenger RNA and protein levels, and miR-106a-5p inhibitor partially rescued this reduction effect in HCC cells. +other 32020560 hsa-mir-106a Colorectal Neoplasms CONCLUSION: MicroRNAs play a significant role in determining prognosis in stage II CRC patients, with upregulation of miR21, miR215, miR143-5p and miR106a, in particular, portending a worse prognosis. +other 32020560 hsa-mir-215 Colorectal Neoplasms CONCLUSION: MicroRNAs play a significant role in determining prognosis in stage II CRC patients, with upregulation of miR21, miR215, miR143-5p and miR106a, in particular, portending a worse prognosis. +other 32020560 hsa-mir-21 Colorectal Neoplasms CONCLUSION: MicroRNAs play a significant role in determining prognosis in stage II CRC patients, with upregulation of miR21, miR215, miR143-5p and miR106a, in particular, portending a worse prognosis. +other 32020560 hsa-mir-143 Colorectal Neoplasms CONCLUSION: MicroRNAs play a significant role in determining prognosis in stage II CRC patients, with upregulation of miR21, miR215, miR143-5p and miR106a, in particular, portending a worse prognosis. +lncRNA target 32020227 hsa-mir-299 Breast Neoplasms Collectively, the results of the present study demonstrated that miR2995p supresses breast cancer cell migration and invasion by targeting STK39. +genetics_overexpression_suppress 32020223 hsa-mir-552 Pancreatic Carcinoma Overexpression of miR5525p in Linc00261overexpressing PC cells increased migration and invasion, as well as decreased the expression of FOXO3 and members of the Wnt signaling pathway. Collectively, the present study demonstrated that Linc00261 inhibited metastasis and the Wnt signaling pathway of PC by regulating the miR5525p/FOXO3 axis. +genetics_overexpression_promote 32020206 hsa-mir-29c Carcinoma, Hepatocellular Overexpression of miR29c3p could significantly inhibit the proliferation and migration of HCC cells in vitro and suppress the HCC tumor growth in vivo. +transcription factor target 32019676 hsa-mir-940 Polycystic Ovary Syndrome 5p was a hub miRNA upregulated in GC from PCOS, and promoted GC proliferation by targeting KCNA5. +genetics_knock down_promote 32019402 hsa-let-7 Behcet Syndrome Here we demonstrated that CRISPR/Cas9-based knockdown of let-7 or the whole cluster promoted endoreduplication and enlargement of the silk gland, accompanied by changing silk yield, whereas transgenic overexpression of let-7 led to atrophy and degeneration of the silk gland. +genetics_knock down_promote 32019402 hsa-let-7 Hypertrophy Here we demonstrated that CRISPR/Cas9-based knockdown of let-7 or the whole cluster promoted endoreduplication and enlargement of the silk gland, accompanied by changing silk yield, whereas transgenic overexpression of let-7 led to atrophy and degeneration of the silk gland. Transgenic overexpression of pyruvate carboxylase, a novel target of let-7, resulted in enlargement of the silk glands, which is consistent with the abnormal phenotype of the let-7 knockdown. +transcription factor target 32019397 hsa-mir-130b Carcinoma, Hepatocellular The biological function and mechanism of miR-130b gene were verified by cell and animal models, and the target gene was verified by double luciferase assay.Results: In the liver cancer tissues of patients with metastasis, the expression level of miR-130b gene was increased, and the difference was significantly significant (p < 0.05). The experiment of luciferase reporter gene confirmed that miR-130b gene can be inhibited and contains fluorescent reporter gene with complementary binding site, lost activity.Conclusion: The miR-130b gene can inhibit the protein expression of Notch-Dll1, and it can promote the invasion and metastasis of liver cancer cells. +lncRNA target 32019274 hsa-mir-214 Sarcoma, Synovial Cooperation between SS18-SSX1 and miR-214 in Synovial Sarcoma Development and Progression. SS18-SSX1 and miR-214 cointroduction accelerated sarcoma onset, indicating that miR-214 is a cooperative oncomiR in synovial sarcomagenesis. +other 32019170 hsa-mir-940 Stomach Neoplasms Evidence exists that salivary miR-940 and miR5p are reliable markers for pancreatic cancer and that miR140-5p and miR301a are promising molecules for the salivary diagnosis of gastric cancer. +other 32019170 hsa-mir-3679 Stomach Neoplasms Evidence exists that salivary miR-940 and miR5p are reliable markers for pancreatic cancer and that miR140-5p and miR301a are promising molecules for the salivary diagnosis of gastric cancer. +other 32019170 hsa-mir-140 Stomach Neoplasms Evidence exists that salivary miR-940 and miR5p are reliable markers for pancreatic cancer and that miR140-5p and miR301a are promising molecules for the salivary diagnosis of gastric cancer. +other 32018221 hsa-mir-130a Necrosis In addition, high-glucose (50 mM) significantly decreased the levels of miR-130a and superoxide dismutase (SOD) 1, and promoted tumor necrosis factor (TNF)-alpha expressions in ARPE-19 cells. +circulation_biomarker_diagnosis_ns 32018074 hsa-mir-21 Heart Arrest Furthermore, the correlation between the serum level of miRNA-21 expression and severity of cardiac dysfunction was analyzed by Spearman correlation analysis. +lncRNA target 32018039 hsa-mir-7 Femur Head Necrosis Bioinformatics analysis indicates circRNA CDR1as, one up-regulated circRNA, may play crucial role in adipogenic/osteogenic differentiation disorder of SONFH-BMSCs via CDR1as-miR5p-WNT5B axis. +other 32017988 hsa-let-7g limb ischemia We have observed that let-7g* liposome-based delivery is capable of attenuating inflammation after stroke, reducing BBB permeability, limiting brain infiltration by CD3(+)CD4(+) T-cells and Ly6G(+) neutrophils, lessening microglia activation and neuronal death. +other 32017988 hsa-let-7g Reperfusion Injury We have observed that let-7g* liposome-based delivery is capable of attenuating inflammation after stroke, reducing BBB permeability, limiting brain infiltration by CD3(+)CD4(+) T-cells and Ly6G(+) neutrophils, lessening microglia activation and neuronal death. +other 32017889 hsa-mir-382 Macular Degeneration In conclusion, circNR3C1 prevents AMD progression and protects RPE by directly sponging miR5p to block its interaction with PTEN and subsequently blocks the AKT/mTOR pathway. +genetics_knock down_promote 32017171 hsa-mir-3666 Carcinoma, Hepatocellular Notably, miR-3666 inhibition or SIRT7 overexpression partially reversed the circPVT1 knockdown-mediated inhibitory effect on HCC cell growth. +lncRNA target 32017082 hsa-mir-200a Lung Neoplasms Overall, LINC00273 promoted TGFbeta-induced lung cancer EMT through miR-200a-3p/ZEB1 feedback loop and may serve as a potential target for therapeutic intervention in lung cancer metastasis. +lncRNA target 32017004 hsa-mir-215 Prostatic Neoplasms 5p alleviates the malignant progression of PCa by targeting and downregulating PGK1. +lncRNA target 32017002 hsa-mir-208a Reperfusion Injury CONCLUSIONS: Our results indicate that the inhibited expression of miR-208a suppresses the expression of autophagy-related factors, enhances cell viability of cardiomyocytes, and reduces apoptosis, thereby protecting neonatal rat cardiomyocytes with SI/RI. +other 32016996 hsa-mir-126 Coronary Artery Disease The results of HE staining manifested that the coronary atherosclerotic plaques were reduced markedly in agomir-126 group,while notably more coronary atherosclerotic plaques were formed in the thoracic aortic region in antagomir-126 group. +lncRNA target 32016994 hsa-mir-21 Aortic Aneurysm, Thoracic CONCLUSIONS: In aortic aneurysm cells of rats, miR-21 could suppress the expression of PTEN and activate MMP-2 and MMP-9 signals to promote the proliferation and migration of aortic aneurysm cells. +lncRNA target 32016992 hsa-mir-10a Sepsis OBJECTIVE: To observe the effect of the micro ribonucleic acid (miR)-10a on sepsis-induced liver injury in rats through the transforming growth factor-b1 (TGF-b1)/Smad signaling pathway. CONCLUSIONS: Silencing miR-10a can inhibit the occurrence of sepsis-induced liver injury in rats by downregulating the TGF-beta1/Smad pathway. +lncRNA target 32016992 hsa-mir-10a Liver Injury OBJECTIVE: To observe the effect of the micro ribonucleic acid (miR)-10a on sepsis-induced liver injury in rats through the transforming growth factor-b1 (TGF-b1)/Smad signaling pathway. CONCLUSIONS: Silencing miR-10a can inhibit the occurrence of sepsis-induced liver injury in rats by downregulating the TGF-beta1/Smad pathway. +lncRNA target 32016991 hsa-mir-144 Cardiomyopathies CONCLUSIONS: LncRNA NEAT1 could interact with miR3p to regulate sepsis-induced myocardial cell injury through the NF-kappaB signaling pathway, which might provide a new theoretical basis for the study on the effect of sepsis treatment. +lncRNA target 32016991 hsa-mir-144 Sepsis CONCLUSIONS: LncRNA NEAT1 could interact with miR3p to regulate sepsis-induced myocardial cell injury through the NF-kappaB signaling pathway, which might provide a new theoretical basis for the study on the effect of sepsis treatment. +lncRNA target 32016990 hsa-mir-29 Cerebral Infarction OBJECTIVE: The aim of this study was to explore the influence of micro ribonucleic acid (miR)-29 on neuronal apoptosis in rats with cerebral infarction by regulating the protein kinase B (Akt) signaling pathway. CONCLUSIONS: MiR-29 inhibits neuronal apoptosis in cerebral infarction rats by upregulatingthe Akt signaling pathway, thereby serving as a protector. +circulation_biomarker_diagnosis_up 32016985 hsa-mir-133b Norrie disease MiR-133b was a target of CASC2 with a high level in serum from DN patients and HG-induced HMCs, and its enrichment reversed the effects of CASC2 upregulation. CONCLUSIONS: CASC2 upregulation suppressed HG-induced proliferation, ECM accumulation and oxidative stress of HMCs through miR-133b /FOXP1 regulatory axis, suggesting that CASC2 was a novel biomarker for DN treatment. +circulation_biomarker_diagnosis_up 32016984 hsa-mir-770 Diabetes, Gestational 5p in the peripheral blood from GDM women and healthy women were investigated by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). +circulation_biomarker_prognosis_ns 32016982 hsa-mir-133 Leukemia, Myeloid, Acute In addition, receiver operator characteristic (ROC) analysis revealed that serum miR-133 could efficiently screen AML patients from normal controls with high sensitivity and specificity. CONCLUSIONS: Low miR-133 expression was a common event and correlated with worse clinical outcome in AML, suggesting that serum miR-133 might serve as a promising indicator for the early detection and prognosis evaluation of AML. +lncRNA target 32016980 hsa-mir-485 Glioma 5p, which may be a potential therapeutic target for glioma. +genetics_knock down_suppress 32016979 hsa-mir-335 Glioma In addition, the knockdown of miRNA-335 partially reversed the regulatory effects of HANR on cellular behaviors of glioma. +lncRNA target 32016977 hsa-mir-15b Breast Neoplasms CONCLUSIONS: Our data stated that miR-15b could facilitate BC progression via repressing tumor suppressor PAQR3, indicating that miR-15b/PAQR3 axis provided a therapeutic target for treating BC. +genetics_overexpression_promote 32016974 hsa-mir-188 Adenocarcinoma of Lung The overexpression of miR-188 inhibits proliferation and promotes apoptosis of LUAD cells, whose functional mechanism may be related to its regulation on the ERK signaling pathway by targeting SIX1. +lncRNA target 32016973 hsa-mir-200a Carcinoma, Non-Small-Cell Lung The prognostic value of miRNA-200a-3p in NSCLC was assessed through the Kaplan-Meier method. +genetics_knock down_suppress 32016972 hsa-mir-140 Carcinoma, Non-Small-Cell Lung 5p knockdown. +other 32016970 hsa-mir-512 Carcinoma, Non-Small-Cell Lung MAGI1-IT1 stimulates proliferative ability in NSCLC by upregulating the AKT1 level by binding to miRNA3p. +genetics_knock down_suppress 32016969 hsa-mir-145 Squamous Cell Carcinoma of Head and Neck 5p knockdown could reverse the regulatory effects of circ-ABCB10 on viability, colony formation, and migratory capacity in OSCC cells. +circulation_biomarker_prognosis_down 32016967 hsa-mir-874 Colorectal Neoplasms CONCLUSIONS: Collectively, serum exosomal miR-874 expression might serve as a reliable marker for CRC diagnosis and prognosis prediction. +lncRNA target 32016965 hsa-mir-1 Carcinoma, Hepatocellular CONCLUSIONS: These results indicated that miR-31 can regulate the expression level of IRF-1 in HCC, which probably provided novel theoretical evidence for the application of target miR-31 treatment of HCC. +lncRNA target 32016963 hsa-mir-128 Prostatic Neoplasms 3p/YES1 axis, showing that targeting TUG1 might be a novel therapeutic strategy for PCa management. +genetics_overexpression_promote 32016960 hsa-mir-654 Ovarian Neoplasms 5p could be sponged by UCA1, and the inhibitory effect of its overexpression on the progression of PTX-resistant OC cells could be reversed by overexpressed-UCA1. +exosome 32016958 hsa-mir-22 Moebius syndrome 1 MiR3p was significantly increased in pMphi-derived exosomes from EMS and delivered from pMphi to eESCs via exosomes. +other 32016955 hsa-mir-145 Osteoarthritis PATIENTS AND METHODS: RT-PCR was used to detect the expressions of NKILA and miR-145 in OA tissues. RESULTS: We found that NKILA and SP1 were significantly reduced, miR-145 was increased in cartilage tissues of OA patients. +circulation_biomarker_diagnosis_up 32016954 hsa-mir-217 Osteoporosis RESULTS: The downregulated TERC and upregulated miRNA-217 were identified in the serum of the OP patients. +other 32016953 hsa-mir-202 Intervertebral Disc Degeneration OBJECTIVE: This study aimed to research the effect of miR5p-mediated ATG7 on autophagy and apoptosis of degenerative nucleus pulposus cells. +lncRNA target 32016950 hsa-mir-411 Spinal Cord Injuries CONCLUSIONS: MiRNA-411 increase ameliorates the inflammatory microglia-induced neurological lesion and promotes neural recovery by JNK pathway inhibition via negative targeting IL-18 in SCI. +lncRNA target 32016798 hsa-mir-135a Polycystic Ovary Syndrome This study provides novel insights into GC dysregulation in PCOS and suggests that miR-135a is a promising therapeutic target for PCOS treatment. +lncRNA target 32016695 hsa-mir-125b-1 Cardiotoxicity Therefore, we inferred that the protective effect of RUT on THP cardiotoxicity was achieved through regulation of the JunD gene by miR-125b3p. +circulation_biomarker_diagnosis_up 32016478 hsa-mir-381 Coronary Disease Decreased miR381 expression and increased CXCR4 expression in the plasma were observed in the CHD group compared with the normal group, which indicated a negative relationship between miR381 and CXCR4. Results from the present study indicated that miR381 was a CHDrelated factor that may serve as a potential molecular target for CHD treatment. +other 32016476 hsa-mir-1911 Head and Neck Neoplasms The present study suggested that hsamiR99a, hsamiR499a and hsamiR1911 may serve as potential prognostic biomarkers in HNC. +other 32016476 hsa-mir-499a Head and Neck Neoplasms The present study suggested that hsamiR99a, hsamiR499a and hsamiR1911 may serve as potential prognostic biomarkers in HNC. +other 32016476 hsa-mir-99a Head and Neck Neoplasms The present study suggested that hsamiR99a, hsamiR499a and hsamiR1911 may serve as potential prognostic biomarkers in HNC. +genetics_overexpression_suppress 32016467 hsa-mir-628 Colorectal Neoplasms miR6285p mimics and CCND1 plasmids were used to overexpress miR6285p and CCND1; it was demonstrated that the expression levels of miR6285p were significantly downregulated in colorectal cancer tissues and cell lines. +lncRNA target 32016462 hsa-mir-374a Ovarian Neoplasms Ovarian cancer cell viability was assessed by the Cell Counting kit8 assay; apoptosis and cell cycle progression were determined by flow cytometry; the relative expression levels of microRNA (miR)374a and forkhead box O1 (FOXO1) were analyzed using reverse transcriptionquantitative PCR; the binding ability of miR374a to FOXO1 was assessed by the dualluciferase reporter assay; cellular sensitivity to DDP was detected using the MTT assay; and finally, the protein expression levels of FOXO1, p27, and Bcl2likeprotein 11 (Bim) were analyzed by western blotting. In conclusion, propofol downregulated miR374a and modulated the FOXO1 pathway to reduce proliferation and DDP resistance in ovarian cancer cells. +genetics_overexpression_promote 32016460 hsa-mir-27a Stomach Neoplasms Overexpression of miR27a3p promoted EMT in AGS gastric cancer cells. +genetics_knock down_suppress 32016455 hsa-mir-149 Carcinoma, Non-Small-Cell Lung Furthermore, PKM2 was involved in NSCLC cell proliferation and invasion, and BCYRN1 knockdown and miR149 overexpression inhibited both processes. The present study suggested that BCYRN1 was involved in cell glycolysis, proliferation and invasion during NSCLC via regulating miR149 and PKM2. +transcription factor target 32016449 hsa-mir-363 Osteoarthritis The expression of miR3633p was negatively correlated with the expression of NRF1, and its expression was significantly upregulated in OA model rats and in LPSinduced chondrocytes compared with the expression in the respective controls. The results of this study suggested that miR3633pmediated inhibition of NRF1may be associated with chondrocyte apoptosis in OA. +other 32015949 hsa-mir-87 Dehydration Moreover, the expression of two novel miRNAs (novel_mir_24 and novel_mir_87) showed notable changes in response to drought stress. +other 32015949 hsa-mir-24 Dehydration Moreover, the expression of two novel miRNAs (novel_mir_24 and novel_mir_87) showed notable changes in response to drought stress. +genetics_knock down_promote 32015692 hsa-mir-517a Melanoma Through loss and gain of function experiments, the interactions between miR-517a, the cyclin dependent kinase inhibitor 1C (CDKN1C) and the c-Jun NH2-terminal kinase (JNK) signaling pathway, as well as their roles in OS of melanoma cells were identified. +lncRNA target 32015687 hsa-mir-335 Pulmonary Arterial Hypertension 3p could be a potential therapeutic target for hypoxic PAH. +circulation_biomarker_diagnosis_ns 32015595 hsa-mir-21 Diabetic Nephropathies The aim of this study was to investigate the level of microRNA-21 as a potential marker of early nephropathy in type 1 diabetes mellitus (T1DM). CONCLUSION: Plasma microRNA-21 can serve as an early marker for diagnosis and identifying diabetic nephropathy in T1DM. +transcription factor target 32014817 hsa-mir-210 Fetal Growth Retardation Integration of the miRNA and RNA sequencing expression data revealed 8 candidate gene targets for miR5p in patients with PE only or PE IUGR. +transcription factor target 32014817 hsa-mir-210 Pre-Eclampsia Integration of the miRNA and RNA sequencing expression data revealed 8 candidate gene targets for miR5p in patients with PE only or PE IUGR. +genetics_overexpression_promote 32014687 hsa-mir-136 Squamous Cell Carcinoma of Head and Neck 5p, and downregulating RAP2C in LSCC cells partially reversed the oncogenic effects of circRNA_100290 overexpression or miR +other 32014577 hsa-mir-340 Spinal Cord Injuries 5p treatment ultimately improved locomotor function recovery in SCI rats. +transcription factor target 32014456 hsa-mir-450a Esophageal Squamous Cell Carcinoma Functional analysis indicated that miR-450a-5p increases cellular radiosensitivity and suppresses autophagy in ESCC cells. In general, our findings indicate that miR-450a-5p is a latent radiosensitizer and may represent a potential novel therapeutic target for radioresistance in ESCC. +lncRNA target 32014424 hsa-mir-873 Osteosarcoma 5p inhibited cell proliferation, metastasis as well as EMT process in osteosarcoma progression. +genetics_GWAS 32014061 hsa-mir-200a Enterocolitis, Necrotizing The current study investigated the biological role of the chicken (Gallus gallus) microRNA-200a-3p (gga-miR-200a-3p), using 2 necrotic enteritis (NE) afflicted genetically disparate chicken lines, 6.3 and 7.2, as well as the mechanisms underlying the fundamental signaling pathways in chicken. The expression of gga-miR-200a-3p in the intestinal mucosal layer of NE-induced chickens, was found to be upregulated during NE infection in the disease-susceptible chicken line 7.2. +transcription factor target 32014006 hsa-mir-299 Carcinoma, Non-Small-Cell Lung 5p/ATF2 axis in A549 cells via the AMPK signalling pathway, thereby inhibiting the proliferation and metastasis of non-small cell lung cancer cells. +genetics_overexpression_promote 32013999 hsa-mir-192 Nasopharyngeal Carcinoma Moreover, overexpression of RB1 weakened the promoted effect of miR-192 in NPC. +other 32013934 hsa-mir-4638 Breast Neoplasms CONCLUSIONS: Changes in expression of hsa-miR3p and hsa-miR-1273 g-3p may contribute to the detection of anthracyclines induced cardiac toxicity, and their potential function may be related to TGF-beta signaling pathway and adhesion signaling pathway. +other 32013934 hsa-mir-1273g Breast Neoplasms CONCLUSIONS: Changes in expression of hsa-miR3p and hsa-miR-1273 g-3p may contribute to the detection of anthracyclines induced cardiac toxicity, and their potential function may be related to TGF-beta signaling pathway and adhesion signaling pathway. +other 32013881 hsa-mir-5021 Diabetes Mellitus, Type 2 miRNA160, miRNA396, miRNA535 and miRNA5021 may be involved in complex network to regulate cell division and differentiation in yam during its expansion stage. +other 32013881 hsa-mir-160 Diabetes Mellitus, Type 2 miRNA160, miRNA396, miRNA535 and miRNA5021 may be involved in complex network to regulate cell division and differentiation in yam during its expansion stage. +other 32013881 hsa-mir-96 Diabetes Mellitus, Type 2 miRNA160, miRNA396, miRNA535 and miRNA5021 may be involved in complex network to regulate cell division and differentiation in yam during its expansion stage. +circulation_biomarker_diagnosis_up 32013852 hsa-mir-223 Stomach Neoplasms In this study, the serum expression of miR-223 in patients with GC was measured and compared with the control group. +other 32013628 hsa-mir-659 Arthritis, Rheumatoid It was identified STAT1, RAC2 and KYNU as hub proteins, PEPD as a receptor, NR4A1, MEOX2, KLF4, IRF1 and MYB as TFs, miR-299, miR-8078, miR-146a, miR-3659 and miR-6882 as key miRNAs. It was determined that biomolecule interaction scenarios using identified key biomolecules and novel biomolecules including RAC2, PEPD, NR4A1, MEOX2, miR-299, miR-8078, miR-3659 and miR-6882 in RA. +other 32013628 hsa-mir-299 Arthritis, Rheumatoid It was identified STAT1, RAC2 and KYNU as hub proteins, PEPD as a receptor, NR4A1, MEOX2, KLF4, IRF1 and MYB as TFs, miR-299, miR-8078, miR-146a, miR-3659 and miR-6882 as key miRNAs. It was determined that biomolecule interaction scenarios using identified key biomolecules and novel biomolecules including RAC2, PEPD, NR4A1, MEOX2, miR-299, miR-8078, miR-3659 and miR-6882 in RA. +other 32013628 hsa-mir-8078 Arthritis, Rheumatoid It was identified STAT1, RAC2 and KYNU as hub proteins, PEPD as a receptor, NR4A1, MEOX2, KLF4, IRF1 and MYB as TFs, miR-299, miR-8078, miR-146a, miR-3659 and miR-6882 as key miRNAs. It was determined that biomolecule interaction scenarios using identified key biomolecules and novel biomolecules including RAC2, PEPD, NR4A1, MEOX2, miR-299, miR-8078, miR-3659 and miR-6882 in RA. +other 32013628 hsa-mir-6882 Arthritis, Rheumatoid It was identified STAT1, RAC2 and KYNU as hub proteins, PEPD as a receptor, NR4A1, MEOX2, KLF4, IRF1 and MYB as TFs, miR-299, miR-8078, miR-146a, miR-3659 and miR-6882 as key miRNAs. It was determined that biomolecule interaction scenarios using identified key biomolecules and novel biomolecules including RAC2, PEPD, NR4A1, MEOX2, miR-299, miR-8078, miR-3659 and miR-6882 in RA. +circulation_biomarker_diagnosis_ns 32013356 hsa-mir-374b Prostatic Neoplasms CONCLUSIONS: Increased miR-374b-5p expression in peripheral blood may serve as a potential biomarker to distinguish PCa patients from healthy controls and BPH patients. +circulation_biomarker_diagnosis_ns 32013342 hsa-mir-129 Bone Neoplasms CONCLUSIONS: In summary, decreased serum miR-129 in breast cancer patients can be used as a potential diagnostic marker of bone metastasis in breast cancer patients. +circulation_biomarker_diagnosis_ns 32013342 hsa-mir-129 Breast Neoplasms CONCLUSIONS: In summary, decreased serum miR-129 in breast cancer patients can be used as a potential diagnostic marker of bone metastasis in breast cancer patients. +lncRNA target 32013265 hsa-mir-451a Stomach Neoplasms To summarize, the present study identified that expression of miR-20b and miR-451a are deregulated in vitro and in vivo and have a tumor suppressive role in GC through regulation of the PI3K/AKT/mTOR signaling pathway. +lncRNA target 32013265 hsa-mir-20b Stomach Neoplasms To summarize, the present study identified that expression of miR-20b and miR-451a are deregulated in vitro and in vivo and have a tumor suppressive role in GC through regulation of the PI3K/AKT/mTOR signaling pathway. +other 32013257 hsa-mir-124 Prostatic Neoplasms In particular, microRNA-124 (miR-124) modulates the expression of carnitine palmitoyltransferase 1A (CPT1A) at the post-transcriptional level, impairing the ability of androgen-independent prostate cancer (PC3) cells to completely metabolize lipid substrates. +other 32013235 hsa-mir-26b Sepsis Septic platelets showed attenuated miR-26b, which were associated with disease severity and mortality. In conclusion, decreased miR-26b in MKs and platelets contributes to an increased level of platelet activation status in sepsis. +lncRNA target 32012470 hsa-mir-153 Esophageal Squamous Cell Carcinoma 3p regulates the proliferation and confers cisplatin resistance in ESCC by targeting the Nrf-2 protein. +lncRNA target 32012318 hsa-mir-422a Esophageal Squamous Cell Carcinoma Further mechanism investigations proved that circUBAP2 exerted its role via sponging microRNA (miR)-422a, and miR-422a directly targeted Rab10 in ESCC cells. These findings suggested that circUBAP2 acted as oncogene through regulating the miR-422a/Rab10 axis in ESCC. +lncRNA target 32012267 hsa-mir-448 Neuralgia Inhibition of Linc00052 could reverse the roles of miR-448 on neuropathic pain development. Taken these together, our study implied that Linc00052 functioned as a novel target of neuropathic pain via sponging miR-448 and regulating JAK1. +other 32012265 hsa-mir-497 Colonic Neoplasms These results suggested that miR5p upregulation could be considered as a therapeutic strategy for modulation of lipid metabolism in colon cancer. +circulation_biomarker_diagnosis_up 32012253 hsa-mir-150 Leukemia, Lymphocytic, Chronic, B-Cell 3p), identified in a pilot study, were examined in serum of 224 CLL cases (diagnosed 3 months to 18 years after enrollment) and 224 matched controls using Taqman based assays. +circulation_biomarker_diagnosis_up 32012253 hsa-mir-155 Leukemia, Lymphocytic, Chronic, B-Cell 3p), identified in a pilot study, were examined in serum of 224 CLL cases (diagnosed 3 months to 18 years after enrollment) and 224 matched controls using Taqman based assays. +circulation_biomarker_diagnosis_up 32012253 hsa-mir-29a Leukemia, Lymphocytic, Chronic, B-Cell 3p), identified in a pilot study, were examined in serum of 224 CLL cases (diagnosed 3 months to 18 years after enrollment) and 224 matched controls using Taqman based assays. +lncRNA target 32012171 hsa-mir-148b Triple Negative Breast Neoplasms Surprisingly, when miR-148b or miR-210 were depleted in triple-negative breast cancer cells, using a specific miR-148b sponge or anti-miR-210, melatonin effects on migration inhibition and c-myc downregulation were still visible suggesting that the increase of miR-148b and miR-210 expression observed following melatonin treatment was not required for the efficacy of melatonin action. +lncRNA target 32012171 hsa-mir-210 Triple Negative Breast Neoplasms Surprisingly, when miR-148b or miR-210 were depleted in triple-negative breast cancer cells, using a specific miR-148b sponge or anti-miR-210, melatonin effects on migration inhibition and c-myc downregulation were still visible suggesting that the increase of miR-148b and miR-210 expression observed following melatonin treatment was not required for the efficacy of melatonin action. +lncRNA target 32010624 hsa-mir-20b Prostatic Neoplasms A novel regulatory mechanism underlying the miR-20b-5p/TGFBR2/E2F1 axis is involved in TGF-beta1-induced EMT of PCa cells, and miR-20b-5p may be a potential therapeutic target for PCa. +lncRNA target 32010565 hsa-mir-30 Carcinoma, Non-Small-Cell Lung 5p to increase the expression of FAM83A, resulting in the inhibition of MAPK signal transduction pathway, thus promoting the progress of NSCLC. +other 32010426 hsa-mir-221 Colorectal Neoplasms Here, we investigated miR-21, miR-221, miR-18a, miR-210, miR-31, miR-34a, miR-10b and miR-16 expression in experimental ALDH(+) and CD44(+)/CD326(+) colorectal CSCs obtained from the human CRC cell lines HCT-116, HT-29 and T-84. +circulation_biomarker_diagnosis_ns 32010426 hsa-mir-18a Colorectal Neoplasms A specific role of miR-18a as metastatic CRC serum biomarker in adult patients was also highlighted. +other 32010426 hsa-mir-16 Colorectal Neoplasms Here, we investigated miR-21, miR-221, miR-18a, miR-210, miR-31, miR-34a, miR-10b and miR-16 expression in experimental ALDH(+) and CD44(+)/CD326(+) colorectal CSCs obtained from the human CRC cell lines HCT-116, HT-29 and T-84. +other 32010426 hsa-mir-34a Colorectal Neoplasms Here, we investigated miR-21, miR-221, miR-18a, miR-210, miR-31, miR-34a, miR-10b and miR-16 expression in experimental ALDH(+) and CD44(+)/CD326(+) colorectal CSCs obtained from the human CRC cell lines HCT-116, HT-29 and T-84. +other 32010426 hsa-mir-21 Colorectal Neoplasms Here, we investigated miR-21, miR-221, miR-18a, miR-210, miR-31, miR-34a, miR-10b and miR-16 expression in experimental ALDH(+) and CD44(+)/CD326(+) colorectal CSCs obtained from the human CRC cell lines HCT-116, HT-29 and T-84. +other 32010426 hsa-mir-210 Colorectal Neoplasms Here, we investigated miR-21, miR-221, miR-18a, miR-210, miR-31, miR-34a, miR-10b and miR-16 expression in experimental ALDH(+) and CD44(+)/CD326(+) colorectal CSCs obtained from the human CRC cell lines HCT-116, HT-29 and T-84. +genetics_knock down_suppress 32010320 hsa-mir-485 Colorectal Neoplasms Knockdown of LINC00707 may inhibit the proliferation of CRC cells by binding with miR5p. +other 32010318 hsa-mir-496 Osteosarcoma Thus, the miR-496/BDNF axis may be a novel strategy for the clinical treatment of OS. +circulation_biomarker_diagnosis_ns 32010305 hsa-mir-214 Cardiomegaly Pearson's correlation analysis revealed that the expression levels of miR-214 and Gal-3 were positively correlated in the peripheral blood of CHF patients (r=0.712, P<0.05). +lncRNA target 32010301 hsa-mir-155 Arthritis, Rheumatoid In RA synovial tissues, miR-155 expression was negatively correlated with FOXO3a expression, but was positively correlated with the release of inflammatory cytokines interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha (TNF-alpha). +genetics_overexpression_promote 32010295 hsa-mir-873 Uterine Cervical Neoplasms In rescue experiments, overexpression of GLI1 in cervical cancer cells effectively reversed the inhibitory effect induced by miR-873 mimics. +other 32010289 hsa-mir-4295 Hemangioma Moreover, miR-4295 was highly expressed in children with hemangioma, and the expression level reduced after two methods of treatment. +lncRNA target 32010277 hsa-mir-665 Ovarian Neoplasms Inhibition of miR-665 inhibited cell proliferation ability and inactivated MAPK/ERK signaling of ovarian cancer cells. +other 32010268 hsa-mir-34a Cataract Expression of miR-34a in cataract rats and its related mechanism were investigated. In conclusion, the upregulation of expression level of miR-34a is related to cataract occurrence in rats, which may be caused by regulation of SIRT1 protein. +lncRNA target 32010267 hsa-mir-135 Osteoporosis In summary, the present results suggested that miR5p participated in the occurrence and development of osteoporosis via inhibition of osteogenic differentiation and osteoblast growth by targeting RUNX2. +lncRNA target 32010262 hsa-mir-182 Retinoblastoma In conclusion, LINC00858 promoted RB cell proliferation, migration and invasion, at least partially by inhibiting miR-3182. +other 32010261 hsa-mir-145 Myocardial Infarction, Acute A recent study showed that metastasis associated lung adenocarcinoma transcript 1 (MALAT1), a prognostic marker for lung cancer metastasis, could promote myocardial ischemia-reperfusion injury by regulating the levels of microRNA (miR)-145. +transcription factor target 32010260 hsa-mir-21 Inflammatory Bowel Diseases 5p may be an important therapy target in human UC. +genetics_overexpression_promote 32010243 hsa-mir-940 Esophageal Squamous Cell Carcinoma Conversely, overexpression of miR-940 reduced the cell viability and promoted apoptosis of ESCC cells. +other 32010197 hsa-mir-135a Adenocarcinoma of Lung The lncRNA RAET1K/miR-135a-5p axis might participate in the regulation of LUAD progression by influencing CCNE1 expression and the accumulation of cells arrested at the G1/S phase boundary. +other 32010177 hsa-mir-221 Triple Negative Breast Neoplasms Much higher expression levels of miR-221/222 were detected in the cisplatin-resistant MDA-MB-231 cells and in cisplatin-resistant breast cancer patients. +other 32010153 hsa-let-7 Multiple Sclerosis In the present study, we demonstrate, using the animal model of MS, experimental autoimmune encephalomyelitis (EAE), that let-7 miRNAs confer protection against EAE by negatively regulating the proliferation, differentiation and chemokine-mediated migration of pathogenic Th17 cells to the CNS. Therefore, our results identify a novel regulatory role for let-7 miRNAs in pathogenic Th17 differentiation during EAE development, suggesting a promising therapeutic application for disease treatment. +circulation_biomarker_diagnosis_up 32009940 hsa-mir-146a Alzheimer Disease We compared miR-146a levels in plasma from 33 AD patients vs. 28 age-matched non-affected controls (CTRL) through quantitative real-time polymerase chain reaction (qRT-PCR). +other 32009856 hsa-mir-21 ankylosing spondylitis 1 OBJECTIVE: To explore the role of microRNA (miR-21) in new bone formation in ankylosing spondylitis (AS) as mediated by different concentration of tumor necrosis factor-alpha (TNF-alpha). CONCLUSIONS: The results revealed that miR-21 may act as a potential mediator between new bone formation and inflammation in AS. +lncRNA target 32009853 hsa-mir-506 Glioma CONCLUSIONS: The findings that YY1-induced SNHG17 facilitated the glioma progression through targeting miR +genetics_GWAS 32009798 hsa-mir-381 Breast Neoplasms CONCLUSIONS: Collectively, EZH2 depletion overcame CDDP resistance of breast cancer through epigenetically silencing miR-381, providing a novel therapeutic target for breast cancer chemoresistance. +genetics_overexpression_promote 32009797 hsa-mir-153 Triple Negative Breast Neoplasms In addition, miR-153 regulated ZEB2/EMT link in TNBC, and ZEB2 overexpression reversed the tumor-suppressive effect of miR-153 in TNBC. +other 32009794 hsa-mir-17 Thyroid Carcinoma, Anaplastic miR-19a, a member of miR92 cluster, has been demonstrated to promote cell growth in anaplastic thyroid cancer (ATC), the most advanced and aggressive thyroid cancer. +lncRNA target 32009794 hsa-mir-19a Thyroid Carcinoma, Anaplastic CONCLUSION: Our findings reveal the existence of functional associations between miR-19a expression and thyroid cancer progression and malignancy suggesting miR-19a as a novel candidate therapeutic target for ATC. +genetics_overexpression_promote 32009419 hsa-mir-148a Stomach Neoplasms In conclusion, overexpression of HOXA11-AS contributed to migration and invasion of GC cells via activation of WNT1/beta-catenin signaling pathway through repressing miR-148a, providing a prospective therapeutic target for GC. +transcription factor target 32009304 hsa-mir-146b Muscle Weakness fold increase, P < 0.05) and dystrophin-targeting miRNAs (miR-146a, miR-146b, miR-31, and miR-223; ~3 +transcription factor target 32009304 hsa-mir-146b Myositis fold increase, P < 0.05) and dystrophin-targeting miRNAs (miR-146a, miR-146b, miR-31, and miR-223; ~3 +transcription factor target 32009304 hsa-mir-455 Myositis fold increase, P < 0.05) and dystrophin-targeting miRNAs (miR-146a, miR-146b, miR-31, and miR-223; ~3 +transcription factor target 32009304 hsa-mir-1 Myositis fold increase, P < 0.05) and dystrophin-targeting miRNAs (miR-146a, miR-146b, miR-31, and miR-223; ~3 +transcription factor target 32009304 hsa-mir-455 Muscle Weakness fold increase, P < 0.05) and dystrophin-targeting miRNAs (miR-146a, miR-146b, miR-31, and miR-223; ~3 +transcription factor target 32009304 hsa-mir-146a Muscle Weakness fold increase, P < 0.05) and dystrophin-targeting miRNAs (miR-146a, miR-146b, miR-31, and miR-223; ~3 +transcription factor target 32009304 hsa-mir-142 Muscle Weakness fold increase, P < 0.05) and dystrophin-targeting miRNAs (miR-146a, miR-146b, miR-31, and miR-223; ~3 +transcription factor target 32009304 hsa-mir-223 Myositis fold increase, P < 0.05) and dystrophin-targeting miRNAs (miR-146a, miR-146b, miR-31, and miR-223; ~3 +transcription factor target 32009304 hsa-mir-146a Myositis fold increase, P < 0.05) and dystrophin-targeting miRNAs (miR-146a, miR-146b, miR-31, and miR-223; ~3 +transcription factor target 32009304 hsa-mir-142 Myositis fold increase, P < 0.05) and dystrophin-targeting miRNAs (miR-146a, miR-146b, miR-31, and miR-223; ~3 +transcription factor target 32009304 hsa-mir-1 Muscle Weakness fold increase, P < 0.05) and dystrophin-targeting miRNAs (miR-146a, miR-146b, miR-31, and miR-223; ~3 +transcription factor target 32009304 hsa-mir-223 Muscle Weakness fold increase, P < 0.05) and dystrophin-targeting miRNAs (miR-146a, miR-146b, miR-31, and miR-223; ~3 +genetics_knock down_promote 32009256 hsa-mir-150 Glioma 5p contributed to CD133- cells with stem cell-like phenotype, whereas overexpression of miR +lncRNA target 32009129 hsa-mir-23 Lung Neoplasms 3p was considered a lung cancer oncogene and could be a valuable target for NSCLC therapy. +circRNA target 32008463 hsa-mir-337 Hypertension, Pulmonary Our results suggested that the circ-calm4/miR3p/Myo10 signal transduction axis modulated the proliferation of pulmonary artery smooth muscle cells at the molecular level, thus establishing potential targets for the early diagnosis and treatment of pulmonary hypertension. +lncRNA target 32008219 hsa-mir-509 Colorectal Neoplasms 5p might be utilized as potential targets for clinical diagnosis and treatment of CRC. +transcription factor target 32007531 hsa-mir-1260 Pulmonary Disease, Chronic Obstructive Further study demonstrated that miR-1260 inhibitor attenuated inflammation in CSE-induced rat COPD lung and in CSE-treated NR8383 cells. +lncRNA target 32006897 hsa-mir-28 Endometrial Neoplasms 5p inhibitor. +other 32006662 hsa-mir-126 Carcinoma Analysis of MM tissue supported the role of PARP1 in miR-126 regulation. +genetics_GWAS 32006196 hsa-mir-27a Infertility, Female The aim of our study is to explore the association between miRNA polymorphisms (mir-320b T>C and mir-27a G >A) and IVF failure. The TT genotype of mir-320b was found more frequently in IVF failure patients when compared to the healthy women (OR 8.07, CI 2.18-29.78, P = 0.001) and T allele was more present in the case group (OR 1.83, CI 91.04-2.12, P = 0.034), however mir-27a seemed to show no association with IVF failure in regards to genotype and allele frequencies. +genetics_GWAS 32006196 hsa-mir-20b Infertility, Female The aim of our study is to explore the association between miRNA polymorphisms (mir-320b T>C and mir-27a G >A) and IVF failure. The TT genotype of mir-320b was found more frequently in IVF failure patients when compared to the healthy women (OR 8.07, CI 2.18-29.78, P = 0.001) and T allele was more present in the case group (OR 1.83, CI 91.04-2.12, P = 0.034), however mir-27a seemed to show no association with IVF failure in regards to genotype and allele frequencies. +transcription factor target 32005873 hsa-mir-4698 Glioblastoma This study proposed to investigate the effect of miR-548x and miR-4698 on the proliferation and the PI3K/AKT signaling pathway in glioblastoma cell lines. Overall, our findings suggest that miR-548x and miR-4698 could function as tumor suppressor genes in glioblastoma by controlling the PI3K/AKT signaling pathway and may act as gene therapy for clinical treatment of glioblastoma multiforme. +transcription factor target 32005803 hsa-mir-132 Heart Failure Therefore, miR-132 may serve as a target for HF therapy. +lncRNA target 32005272 hsa-mir-509 Ovarian Neoplasms, High-Grade Serous 3 can sensitize ovarian cancer cells to Olaparib by impeding HR, which makes it a potential target in PARPi synergistic treatment. +circRNA target 32005118 hsa-mir-340 Colorectal Neoplasms More importantly, we also found that circ_001680 could promote the cancer stem cell (CSC) population in CRC and induce irinotecan therapeutic resistance by regulating the miR-340 target gene BMI1. +other 32005028 hsa-mir-101 Esophageal Squamous Cell Carcinoma CONCLUSION: PSMA3-AS1 is significantly up-regulated in ESCC tissues, and the PSMA3-AS1/miR-101/EZH2 axis plays a critical role in ESCC progression. METHODS: PSMA3-AS1 and miR-101 expression were explored using qRT-PCR in ESCC tissues and cell lines. +circulation_biomarker_diagnosis_up 32004974 hsa-mir-155 Wilms Tumor 5p was downregulated in both blood and tissues from WT patients who did not receive chemotherapy before surgery but was upregulated in tissues from WT patients who had received chemotherapy before surgery. +other 32004619 hsa-mir-196a-2 Hepatitis B, Chronic Comparing the immune-active CHB patients with delayed spontaneous HBeAg seroconversion (persistent HBeAg seropositivity, older than 40 years) to those with early inefficient HBeAg seroconversion (HBeAg seroconversion with high viremia, younger than 40 years), logistic analysis revealed that rs3820998 (TANK), rs2621377 (HLA-DOB), rs3130215 (HLA-DPB2), rs2255336 (KLRK1), and rs11614913 (MIR-196A2) were significantly associated with delayed spontaneous HBeAg seroconversion. +circulation_biomarker_diagnosis_up 32004570 hsa-mir-619 Carcinoma, Non-Small-Cell Lung 5p expression was higher than normal in exosomes isolated from the plasma of NSCLC patients. +exosome 32004570 hsa-mir-619 Lung Neoplasms Our findings indicate that exosomal miR5p promotes the growth and metastasis of NSCLCs by regulating RCAN1.4 and can serve as a diagnostic indicator for these lung cancers. +other 32004541 hsa-mir-200 Hypoxia Notch1 signaling pathway and three members of miR-200 family, miR-429, miR-200a and miR-200b, are reported to have tight connection with hypoxia-induced injury. +other 32004541 hsa-mir-200b Hypoxia Notch1 signaling pathway and three members of miR-200 family, miR-429, miR-200a and miR-200b, are reported to have tight connection with hypoxia-induced injury. These results may clarify the roles of miR-429/200a/200b and Notch1 signaling pathway in hypoxia-induced nerve injury and provide a new theoretical basis to relieve nerve injury. +other 32004541 hsa-mir-429 Hypoxia Notch1 signaling pathway and three members of miR-200 family, miR-429, miR-200a and miR-200b, are reported to have tight connection with hypoxia-induced injury. These results may clarify the roles of miR-429/200a/200b and Notch1 signaling pathway in hypoxia-induced nerve injury and provide a new theoretical basis to relieve nerve injury. +other 32004541 hsa-mir-429 Cranial Nerve Injuries These results may clarify the roles of miR-429/200a/200b and Notch1 signaling pathway in hypoxia-induced nerve injury and provide a new theoretical basis to relieve nerve injury. +other 32004541 hsa-mir-200a Hypoxia Notch1 signaling pathway and three members of miR-200 family, miR-429, miR-200a and miR-200b, are reported to have tight connection with hypoxia-induced injury. +other 32004541 hsa-mir-200b Cranial Nerve Injuries These results may clarify the roles of miR-429/200a/200b and Notch1 signaling pathway in hypoxia-induced nerve injury and provide a new theoretical basis to relieve nerve injury. +lncRNA target 32004504 hsa-mir-411 Pulmonary Fibrosis 3p abrogates silicosis by blocking activation of TGF-beta/Smad signaling through decreasing ubiquitination degradation effect of smurf2 on Smad7. +lncRNA target 32004389 hsa-mir-19a Carcinoma, Squamous Cell Interestingly, RP11-874J12.4 and miR-19a-5p form a negative regulatory loop that inhibits the expression of miR-19a-5p in OSCC. The expression of an oncogenic transcription factor, EBF1, is unleashed in OSCC due to the low expression of miR-19a-5p, which promotes the growth and migration of OSCC. +lncRNA target 32004259 hsa-mir-335 Adenocarcinoma of Lung 3p targeting by COPB2 in lung adenocarcinoma cells. +genetics_knock down_promote 32003827 hsa-mir-191 Endometrial Neoplasms We showed that miR-191 was upregulated in EC tissues than in adjacent normal tissues and its knockdown repressed EC cell proliferation. +lncRNA target 32003753 hsa-mir-223 Liver Cirrhosis 3p sponge that inhibited HSC activation in liver fibrosis via regulation of miR +other 32003752 hsa-mir-193a Wounds and Injuries OBJECTIVE: The functions and molecular regulatory mechanisms of miR-193a-3p in cardiac injury induced by obstructive sleep apnea (OSA) are poorly understood. +other 32003672 hsa-mir-335 Cognition Disorders 5p, may be a potential mechanism that contributes to Abeta accumulation and AD progression, indicating a novel approach for AD treatment. +other 32003672 hsa-mir-335 Alzheimer Disease 5p, may be a potential mechanism that contributes to Abeta accumulation and AD progression, indicating a novel approach for AD treatment. +lncRNA target 32003671 hsa-mir-429 Pneumonia CONCLUSION: MiR-429 promotes inflammatory injury, apoptosis and activates the NF-kappaB signaling pathway by targeting KLF4 in neonatal pneumonia, and then these results provide evidence for clinical diagnosis and treatment for neonatal pneumonia. +lncRNA target 32003671 hsa-mir-429 Inflammation CONCLUSION: MiR-429 promotes inflammatory injury, apoptosis and activates the NF-kappaB signaling pathway by targeting KLF4 in neonatal pneumonia, and then these results provide evidence for clinical diagnosis and treatment for neonatal pneumonia. +lncRNA target 32003509 hsa-mir-6884 Breast Neoplasms Taken together, this study revealed that RHPN1-AS1 was induced by KDM5B and promoted BC via the RHPN1-AS1/miR +genetics_overexpression_promote 32003017 hsa-mir-802 Carcinoma, Hepatocellular These data demonstrate increased miR-802 expression in patients with HCC and that miR-802 overexpression promotes tumor cell growth, in a RUNX3-dependent manner. +other 32003016 hsa-mir-155 Breast Neoplasms Considering the above, in this study, we designed and fabricated a nanocarrier composed of gold nanoparticles (GNPs), antagomir-155, and nucleolin specific aptamer for breast cancer study and therapy. Our results suggest that AuNP-Apt-anti-miR-155 could be a promising nano constructor for breast cancer treatment. +genetics_overexpression_promote 32002629 hsa-mir-1224 Laryngeal Papillomas Overexpression of the miR +lncRNA target 32002587 hsa-mir-425 Liver Diseases 5p/RIP1 axis is a potential therapeutic strategy for sepsis-related liver damage through necroptosis and inflammation. +lncRNA target 32002587 hsa-mir-425 Inflammation 5p/RIP1 axis is a potential therapeutic strategy for sepsis-related liver damage through necroptosis and inflammation. +other 32002372 hsa-mir-146a Colorectal Neoplasms The purpose of this study is to examine the role of miR-146 a-5p and -193 a-5p in CRC cell cycle progression. Thus, miRNA-146a-5p and -193a-5p restoration may be recommended as a potential therapeutic goal in the treatment of CRC patients. +other 32002372 hsa-mir-146 Colorectal Neoplasms The purpose of this study is to examine the role of miR-146 a-5p and -193 a-5p in CRC cell cycle progression. Thus, miRNA-146a-5p and -193a-5p restoration may be recommended as a potential therapeutic goal in the treatment of CRC patients. +genetics_overexpression_promote 32002032 hsa-mir-608 Carcinoma, Pancreatic Ductal Bioinformatics analysis was then performed to predict the molecular mechanism underlying the regulation of cell apoptosis by miRNA-608, and a dual-luciferase assay determined that overexpression of mimics in the Panc-1 and Bxpc-3 pancreatic cancer cell lines increased levels of apoptosis compared with the control. +genetics_overexpression_promote 32002031 hsa-mir-3677 Breast Neoplasms The overexpression of miR-3677 promoted the cell proliferation, migration and invasion of BC cells. +lncRNA target 32002028 hsa-mir-526b Carcinoma, Non-Small-Cell Lung PVT1 accelerates the progression of NSCLC via targeting miRNA-526b/EZH2 regulatory loop. +other 32001303 hsa-mir-7 Leishmaniasis, Diffuse Cutaneous 3p (p = 0.002), and cytokine levels for IL-1beta (p = 0.0005), IL-6 (p = 0.001), and IL-17 (p = 0.001) in patients with cutaneous leishmaniasis compared to the controls. +other 32001303 hsa-mir-146b Leishmaniasis, Diffuse Cutaneous 3p (p = 0.002), and cytokine levels for IL-1beta (p = 0.0005), IL-6 (p = 0.001), and IL-17 (p = 0.001) in patients with cutaneous leishmaniasis compared to the controls. +other 32001303 hsa-mir-28 Leishmaniasis, Diffuse Cutaneous 3p (p = 0.002), and cytokine levels for IL-1beta (p = 0.0005), IL-6 (p = 0.001), and IL-17 (p = 0.001) in patients with cutaneous leishmaniasis compared to the controls. +other 32001303 hsa-mir-223 Leishmaniasis, Diffuse Cutaneous 3p (p = 0.002), and cytokine levels for IL-1beta (p = 0.0005), IL-6 (p = 0.001), and IL-17 (p = 0.001) in patients with cutaneous leishmaniasis compared to the controls. +other 32001303 hsa-mir-133a Leishmaniasis, Diffuse Cutaneous 3p (p = 0.002), and cytokine levels for IL-1beta (p = 0.0005), IL-6 (p = 0.001), and IL-17 (p = 0.001) in patients with cutaneous leishmaniasis compared to the controls. +other 32001271 hsa-mir-214 Glioma SIGNIFICANCE: This study identified circRNAs expression profile in gliomas and revealed that circ_0037655 could promote glioma progression by regulating miR-214/PI3K signaling, which may provide new therapeutic approach for gliomas. +transcription factor target 32001264 hsa-mir-34a Nerve Degeneration SIGNIFICANCE: DEX could inhibit propofol-induced neuronal injury in rat hippocampus by inhibiting miR-34a expression, upregulating SIRT1 and activating the PI3K/Akt pathway. +genetics_GWAS 32000889 hsa-mir-27a Amyotrophic Lateral Sclerosis MATERIALS AND METHODS: We measured the expression levels of muscle-specific microRNAs (miR-1, miR-133a, miR-133b, miR-206), inflammatory micro-RNAs (miR-27a, miR-221, miR-155), and HDAC4 protein content on western blotting in muscle biopsies obtained for diagnostic reasons in 18 ALS patients: 8 genetic forms (C9-ALS and SOD1-ALS), 5 sporadic cases (SALS), and 5 ALS cases affected only by upper motor neuron disease (UMN). +genetics_GWAS 32000889 hsa-mir-133b Amyotrophic Lateral Sclerosis MATERIALS AND METHODS: We measured the expression levels of muscle-specific microRNAs (miR-1, miR-133a, miR-133b, miR-206), inflammatory micro-RNAs (miR-27a, miR-221, miR-155), and HDAC4 protein content on western blotting in muscle biopsies obtained for diagnostic reasons in 18 ALS patients: 8 genetic forms (C9-ALS and SOD1-ALS), 5 sporadic cases (SALS), and 5 ALS cases affected only by upper motor neuron disease (UMN). +genetics_GWAS 32000889 hsa-mir-206 Amyotrophic Lateral Sclerosis MATERIALS AND METHODS: We measured the expression levels of muscle-specific microRNAs (miR-1, miR-133a, miR-133b, miR-206), inflammatory micro-RNAs (miR-27a, miR-221, miR-155), and HDAC4 protein content on western blotting in muscle biopsies obtained for diagnostic reasons in 18 ALS patients: 8 genetic forms (C9-ALS and SOD1-ALS), 5 sporadic cases (SALS), and 5 ALS cases affected only by upper motor neuron disease (UMN). +genetics_GWAS 32000889 hsa-mir-133a Amyotrophic Lateral Sclerosis MATERIALS AND METHODS: We measured the expression levels of muscle-specific microRNAs (miR-1, miR-133a, miR-133b, miR-206), inflammatory micro-RNAs (miR-27a, miR-221, miR-155), and HDAC4 protein content on western blotting in muscle biopsies obtained for diagnostic reasons in 18 ALS patients: 8 genetic forms (C9-ALS and SOD1-ALS), 5 sporadic cases (SALS), and 5 ALS cases affected only by upper motor neuron disease (UMN). +genetics_GWAS 32000889 hsa-mir-1 Amyotrophic Lateral Sclerosis MATERIALS AND METHODS: We measured the expression levels of muscle-specific microRNAs (miR-1, miR-133a, miR-133b, miR-206), inflammatory micro-RNAs (miR-27a, miR-221, miR-155), and HDAC4 protein content on western blotting in muscle biopsies obtained for diagnostic reasons in 18 ALS patients: 8 genetic forms (C9-ALS and SOD1-ALS), 5 sporadic cases (SALS), and 5 ALS cases affected only by upper motor neuron disease (UMN). +genetics_GWAS 32000889 hsa-mir-221 Amyotrophic Lateral Sclerosis MATERIALS AND METHODS: We measured the expression levels of muscle-specific microRNAs (miR-1, miR-133a, miR-133b, miR-206), inflammatory micro-RNAs (miR-27a, miR-221, miR-155), and HDAC4 protein content on western blotting in muscle biopsies obtained for diagnostic reasons in 18 ALS patients: 8 genetic forms (C9-ALS and SOD1-ALS), 5 sporadic cases (SALS), and 5 ALS cases affected only by upper motor neuron disease (UMN). +genetics_GWAS 32000889 hsa-mir-155 Amyotrophic Lateral Sclerosis MATERIALS AND METHODS: We measured the expression levels of muscle-specific microRNAs (miR-1, miR-133a, miR-133b, miR-206), inflammatory micro-RNAs (miR-27a, miR-221, miR-155), and HDAC4 protein content on western blotting in muscle biopsies obtained for diagnostic reasons in 18 ALS patients: 8 genetic forms (C9-ALS and SOD1-ALS), 5 sporadic cases (SALS), and 5 ALS cases affected only by upper motor neuron disease (UMN). +transcription factor target 32000791 hsa-mir-188 Influenza, Human 3p downregulated PB2 expression at both mRNA and protein levels by directly targeted the predicted sites on PB2 and effectively inhibited the replication of IAV (H1N1, H5N6 and H7N9) in A549 cells. +genetics_overexpression_promote 32000296 hsa-let-7g Glioblastoma VB treatment or let-7g-5p overexpression inhibited HMGA2 expression and the activation of Wnt/beta-catenin signalling pathway, which further inhibited cell viability, invasion, migration, tumour growth and promoted GBM cell apoptosis and autophagy. +genetics_GWAS 32000230 hsa-mir-146a Behcet Syndrome METHODS: The distributions of FAS-670 A>G rs1800682, mir146a rs2910164, and mir196a rs11614913 polymorphisms are analyzed with the polymerase chain reaction-restriction fragment length polymorphism method in 115 BD patients and 220 controls in 6-month period. CONCLUSIONS: These findings indicate that both Fas rs1800682 and mir-146a rs2910164 variants might be important factors participating in the protection against BD in the Turkish population. +genetics_overexpression_promote 32000044 hsa-mir-154 Osteosarcoma Furthermore, in vivo assays indicated that overexpression of miR +lncRNA target 32000043 hsa-mir-652 Reperfusion Injury, Cerebral Ischemia These data indicated that miR-652 protected rats from cerebral ischemia reperfusion injury by directly targeting NOX2, is a novel target for ischemic stroke therapy. +lncRNA target 32000032 hsa-mir-20b Glioblastoma In summary, LINC00680 and TTN-AS1 promoted glioblastoma cell malignant biological behaviors via the miR-320b/EGR3/PKP2 axis by being stabilized by EIF4A3, which may provide a novel strategy for glioblastoma therapy. +other 31999938 hsa-mir-126 Myocardial Infarction Overall, we showed that miR-126 promoted the biological function of EPCs under H2O2-induced oxidative stress by activating the PI3K/Akt/GSK3beta and ERK1/2 signaling pathway, which may serve as a new therapeutic approach to treat AMI. +genetics_overexpression_suppress 31999936 hsa-mir-129 Glioblastoma 5p in LN229 and A172 cells significantly inhibited ZFP36L1 mRNA and protein expression, while overexpression of ZFP36L1 in LN229 and A172 cells reversed miR +transcription factor target 31999493 hsa-mir-29c Osteosarcoma Moreover, reexpression of miR-29c reversed the effect of lnc-SERTAD2-3 on OS cells. Conclusion: Overall, lnc-SERTAD2-3, an OS suppressor, is involved in the inhibition of OS proliferation and migration by targeting miR-29c. +lncRNA target 31999471 hsa-mir-146a Necrosis Thus, we suggest that the ratio between miR-146a and Merlin protein levels could be a relevant molecular biomarker that can predict lung cancer progression and that the TNF/miR-146a/Merlin pathway is a promising new therapeutic target to inhibit lung adenocarcinoma progression. +lncRNA target 31999471 hsa-mir-146a Adenocarcinoma of Lung Thus, we suggest that the ratio between miR-146a and Merlin protein levels could be a relevant molecular biomarker that can predict lung cancer progression and that the TNF/miR-146a/Merlin pathway is a promising new therapeutic target to inhibit lung adenocarcinoma progression. +lncRNA target 31998791 hsa-mir-384 Thyroid Cancer, Papillary The ectopic upregulation of miR-384 significantly suppressed PTC progression, and the inhibition of miR-384 had the opposite effects. +other 31998559 hsa-mir-133a Osteosarcoma Multivariate survival analysis demonstrated that miRNA-21 (hazard ratio (HR): 3.457, 95% CI [2.165-11.518]), miRNA (HR: 3.138, 95% CI [2.014-10.259]), miRNA-34a (HR: 0.452, 95% CI [0.202-0.915]), miRNA-133a (HR: 0.307, 95% CI [0.113-0.874]) and miRNA-539 (HR: 0.358, 95% CI [0.155-0.896]) were independent prognostic markers of OS patients after adjusting for TNM stage (HR: 2.893, 95% CI [1.496-8.125]), metastasis or recurrence (HR: 3.628, 95% CI [2.217-12.316]) and miRNA-30c (HR: 0.689, 95% CI [0.445-1.828]). CONCLUSIONS: High expression of miRNA-21 and miRNA-214 and low expression of miRNA-34a, miRNA-133a and miRNA-539 were associated with poor prognosis of OS patients after adjusting for TNM stage, metastasis or recurrence and miRNA-30c. +other 31998559 hsa-mir-34a Osteosarcoma Multivariate survival analysis demonstrated that miRNA-21 (hazard ratio (HR): 3.457, 95% CI [2.165-11.518]), miRNA (HR: 3.138, 95% CI [2.014-10.259]), miRNA-34a (HR: 0.452, 95% CI [0.202-0.915]), miRNA-133a (HR: 0.307, 95% CI [0.113-0.874]) and miRNA-539 (HR: 0.358, 95% CI [0.155-0.896]) were independent prognostic markers of OS patients after adjusting for TNM stage (HR: 2.893, 95% CI [1.496-8.125]), metastasis or recurrence (HR: 3.628, 95% CI [2.217-12.316]) and miRNA-30c (HR: 0.689, 95% CI [0.445-1.828]). CONCLUSIONS: High expression of miRNA-21 and miRNA-214 and low expression of miRNA-34a, miRNA-133a and miRNA-539 were associated with poor prognosis of OS patients after adjusting for TNM stage, metastasis or recurrence and miRNA-30c. +other 31998559 hsa-mir-539 Osteosarcoma Multivariate survival analysis demonstrated that miRNA-21 (hazard ratio (HR): 3.457, 95% CI [2.165-11.518]), miRNA (HR: 3.138, 95% CI [2.014-10.259]), miRNA-34a (HR: 0.452, 95% CI [0.202-0.915]), miRNA-133a (HR: 0.307, 95% CI [0.113-0.874]) and miRNA-539 (HR: 0.358, 95% CI [0.155-0.896]) were independent prognostic markers of OS patients after adjusting for TNM stage (HR: 2.893, 95% CI [1.496-8.125]), metastasis or recurrence (HR: 3.628, 95% CI [2.217-12.316]) and miRNA-30c (HR: 0.689, 95% CI [0.445-1.828]). CONCLUSIONS: High expression of miRNA-21 and miRNA-214 and low expression of miRNA-34a, miRNA-133a and miRNA-539 were associated with poor prognosis of OS patients after adjusting for TNM stage, metastasis or recurrence and miRNA-30c. +other 31998559 hsa-mir-21 Osteosarcoma Multivariate survival analysis demonstrated that miRNA-21 (hazard ratio (HR): 3.457, 95% CI [2.165-11.518]), miRNA (HR: 3.138, 95% CI [2.014-10.259]), miRNA-34a (HR: 0.452, 95% CI [0.202-0.915]), miRNA-133a (HR: 0.307, 95% CI [0.113-0.874]) and miRNA-539 (HR: 0.358, 95% CI [0.155-0.896]) were independent prognostic markers of OS patients after adjusting for TNM stage (HR: 2.893, 95% CI [1.496-8.125]), metastasis or recurrence (HR: 3.628, 95% CI [2.217-12.316]) and miRNA-30c (HR: 0.689, 95% CI [0.445-1.828]). CONCLUSIONS: High expression of miRNA-21 and miRNA-214 and low expression of miRNA-34a, miRNA-133a and miRNA-539 were associated with poor prognosis of OS patients after adjusting for TNM stage, metastasis or recurrence and miRNA-30c. +circulation_biomarker_diagnosis_ns 31998452 hsa-mir-146a Ventricular Premature Complexes The aim of this study was to evaluate the expression of messenger RNAs (mRNAs) and the protein production of interleukin-6 (IL-6), IL-10, tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma) and two circulating micro-RNAs related to inflammation and cardiovascular disease; miR-155 and miR-146. +circulation_biomarker_diagnosis_ns 31998452 hsa-mir-155 Ventricular Premature Complexes The aim of this study was to evaluate the expression of messenger RNAs (mRNAs) and the protein production of interleukin-6 (IL-6), IL-10, tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma) and two circulating micro-RNAs related to inflammation and cardiovascular disease; miR-155 and miR-146. +circulation_biomarker_diagnosis_ns 31998452 hsa-mir-146 Ventricular Premature Complexes The aim of this study was to evaluate the expression of messenger RNAs (mRNAs) and the protein production of interleukin-6 (IL-6), IL-10, tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma) and two circulating micro-RNAs related to inflammation and cardiovascular disease; miR-155 and miR-146. +circulation_biomarker_diagnosis_ns 31998452 hsa-mir-155 Cardiomyopathies The aim of this study was to evaluate the expression of messenger RNAs (mRNAs) and the protein production of interleukin-6 (IL-6), IL-10, tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma) and two circulating micro-RNAs related to inflammation and cardiovascular disease; miR-155 and miR-146. +circulation_biomarker_diagnosis_ns 31998452 hsa-mir-146a Cardiomyopathies The aim of this study was to evaluate the expression of messenger RNAs (mRNAs) and the protein production of interleukin-6 (IL-6), IL-10, tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma) and two circulating micro-RNAs related to inflammation and cardiovascular disease; miR-155 and miR-146. +circulation_biomarker_diagnosis_ns 31998452 hsa-mir-146 Cardiomyopathies The aim of this study was to evaluate the expression of messenger RNAs (mRNAs) and the protein production of interleukin-6 (IL-6), IL-10, tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma) and two circulating micro-RNAs related to inflammation and cardiovascular disease; miR-155 and miR-146. +lncRNA target 31998373 hsa-mir-4793 Colorectal Neoplasms Taken together, our study reveals that SHU00238 promotes colorectal cancer cell apoptosis through miR +lncRNA target 31998373 hsa-mir-4701 Colorectal Neoplasms Taken together, our study reveals that SHU00238 promotes colorectal cancer cell apoptosis through miR +genetics_overexpression_promote 31997941 hsa-mir-4319 Stomach Neoplasms Subsequently, ENTPD4, the target gene of miR-4319, was found overexpressed in GC. +lncRNA target 31997940 hsa-mir-625 Adenocarcinoma of Lung CONCLUSIONS: LINC00958 might drive LAD progression via mediating miR +lncRNA target 31997826 hsa-mir-668 Reperfusion Injury 3p suppressed mediators of inflammation and oxidative stress and enhanced cell viability through the SDF-1/CXCR4 signaling pathway. +lncRNA target 31997569 hsa-mir-192 Enteropathy-Associated T-Cell Lymphoma Our results revealed lymphoma-specific expression patterns, with down-regulation of the tumour-suppressing microRNAs miR-194, miR-192, miR-141 and miR-203, and up-regulation of oncogenic microRNAs, including microRNAs from the miR-106a~363 cluster. +lncRNA target 31997569 hsa-mir-106a Enteropathy-Associated T-Cell Lymphoma Our results revealed lymphoma-specific expression patterns, with down-regulation of the tumour-suppressing microRNAs miR-194, miR-192, miR-141 and miR-203, and up-regulation of oncogenic microRNAs, including microRNAs from the miR-106a~363 cluster. +lncRNA target 31997569 hsa-mir-141 Enteropathy-Associated T-Cell Lymphoma Our results revealed lymphoma-specific expression patterns, with down-regulation of the tumour-suppressing microRNAs miR-194, miR-192, miR-141 and miR-203, and up-regulation of oncogenic microRNAs, including microRNAs from the miR-106a~363 cluster. +lncRNA target 31997569 hsa-mir-203 Enteropathy-Associated T-Cell Lymphoma Our results revealed lymphoma-specific expression patterns, with down-regulation of the tumour-suppressing microRNAs miR-194, miR-192, miR-141 and miR-203, and up-regulation of oncogenic microRNAs, including microRNAs from the miR-106a~363 cluster. +lncRNA target 31997569 hsa-mir-194 Enteropathy-Associated T-Cell Lymphoma Our results revealed lymphoma-specific expression patterns, with down-regulation of the tumour-suppressing microRNAs miR-194, miR-192, miR-141 and miR-203, and up-regulation of oncogenic microRNAs, including microRNAs from the miR-106a~363 cluster. +lncRNA target 31997404 hsa-mir-342 Aortic Aneurysm, Abdominal CircCCDC66 upregulated its host gene through its role of miR +other 31997281 hsa-mir-17 Stomach Neoplasms 5p genes in gastric cancer patients with Helicobacter pylori infection. +other 31997075 hsa-mir-4723 Alzheimer Disease Potential upstream modulators of such unique proteomic profile are miRNA-485, miRNA-4723 and miRNA-149, which we found differentially expressed in AD and NDAN vs. +other 31997075 hsa-mir-149 Alzheimer Disease Potential upstream modulators of such unique proteomic profile are miRNA-485, miRNA-4723 and miRNA-149, which we found differentially expressed in AD and NDAN vs. +other 31997075 hsa-mir-485 Alzheimer Disease Potential upstream modulators of such unique proteomic profile are miRNA-485, miRNA-4723 and miRNA-149, which we found differentially expressed in AD and NDAN vs. +lncRNA target 31996784 hsa-mir-141 Carcinoma, Hepatocellular Together, our findings suggest that ERalpha can suppress HCC cell invasion via altering the ERalpha/circRNA-SMG1.72/miR +exosome 31996459 hsa-mir-22 Encephalitis, Japanese Based on our previous sequencing results of noncoding RNA in JEV-infected cells, microRNA-22 (miR-22) was identified to be a key regulator for MAVS expression during JEV infection. +other 31996191 hsa-mir-7109 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: Our study suggested that miR5p and miR-34b might play important roles in the metastasis of OSCC by regulating MMP7 and MMP13 expression, respectively. +other 31996191 hsa-mir-34b Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: Our study suggested that miR5p and miR-34b might play important roles in the metastasis of OSCC by regulating MMP7 and MMP13 expression, respectively. +target gene 31996026 hsa-mir-383 Necrosis In contrast to miR-210, which inhibited oxidative phosphorylation and enhanced mitochondrial reactive oxygen species production, miR-383 increased ATP levels and inhibited necroptosis. +target gene 31996026 hsa-mir-210 Necrosis In contrast to miR-210, which inhibited oxidative phosphorylation and enhanced mitochondrial reactive oxygen species production, miR-383 increased ATP levels and inhibited necroptosis. +genetics_overexpression_suppress 31995775 hsa-mir-155 Skin Diseases In immortalized human keratinocytes, silencing and overexpression of NF-AT1 could alter the expression and secretion of immunological dysfunction indicators (IL-2 and IFN-gamma) that are induced by arsenic exposure (p < 0.05); however, miR +genetics_overexpression_promote 31995644 hsa-mir-200a Spinal Cord Injuries These results indicated that overexpressed miR-200a in BMSCs promoted SCI repair, which may be through regulating antioxidative signaling pathway. +lncRNA target 31995261 hsa-mir-326 Squamous Cell Carcinoma of Head and Neck MTA2 axis may contribute to a better understanding of OSCC pathogenesis and be a potential therapeutic target for OSCC. +transcription factor target 31994915 hsa-mir-155 Arthritis, Rheumatoid Thus, TDZD-8 protects against CIA in rats for a period of 6 weeks, which is associated with the inhibition of miR155/24 and inflammation, and apoptosis augmentation. +transcription factor target 31994915 hsa-mir-24 Arthritis, Rheumatoid Thus, TDZD-8 protects against CIA in rats for a period of 6 weeks, which is associated with the inhibition of miR155/24 and inflammation, and apoptosis augmentation. +genetics_overexpression_promote 31994910 hsa-mir-1262 Breast Neoplasms The poor prognosis of patients with BC was associated with the up-regulation of LRP8 while inversely connected with overexpression of miR-1262. +lncRNA target 31994731 hsa-mir-133a Osteosarcoma Furthermore, PTHR1 downregulation restored the impacts of inhibited miR-133a-3p on the processes in osteosarcoma cells. +lncRNA target 31994599 hsa-mir-383 Inflammation Previous research has shown that suppression of miR-383 can prevent inflammation of the endothelium, as well as postpone the development of atherosclerosis. +genetics_GWAS 31994428 hsa-mir-182 Breast Neoplasms A genetic variant in the flanking region of miR-182 could decrease the susceptibility to the breast cancer risk in the iranian population. In this study, the association of rs4541843 in the flanking region of the miR-182 sequence with the susceptibility to breast cancer risk has been studied in the Iranian population. +circulation_biomarker_diagnosis_ns 31994346 hsa-mir-21 Carcinoma, Non-Small-Cell Lung 5p and 210-3p) and one plasma miRNA (miR +genetics_overexpression_suppress 31994318 hsa-mir-1254 Glioma The CSF-1 down-regulation or miR-1254 overexpression impeded the invasion, proliferation and migratory ability of U251 and U87 glioma cells, concurrently occluded the cell cycle and induced cell apoptosis. +genetics_knock down_promote 31994189 hsa-mir-218 Carcinoma, Hepatocellular In summary, knockdown of TINCR suppressed HCC progression presumably by inactivation of AKT signaling through targeting the miR +lncRNA target 31994011 hsa-mir-23a Carcinoma, Hepatocellular The miR-23a-3p could be considered as a molecular target for HCC detection. +lncRNA target 31994002 hsa-mir-17 cervical squamous cell carcinoma Therefore, NR2F1-AS1 regulates miR-17/SIK1 axis to suppress the invasion and migration of CSCC cells. +circulation_biomarker_diagnosis_ns 31993806 hsa-mir-1306 Fetal Growth Retardation 3p in maternal peripheral blood had potential significance for FGR. +lncRNA target 31993313 hsa-mir-28 Opitz GBBB Syndrome, X-Linked 3p did not alter homeostasis of amino acids within OS cells, suppression of GLUT1 led to a significantly lower glucose uptake and decline in intracellular levels of glucose and glycolytic metabolite lactate. +lncRNA target 31993313 hsa-mir-28 Osteosarcoma 3p to suppress the growth of highly-proliferative human osteosarcoma (OS) cells. +other 31992960 hsa-mir-134 Retinoblastoma CONCLUSIONS: This research unmasked a novel DNM3OS/miR5p/SMAD6 pathway in RB, which might make contribution to treatment of RB. +lncRNA target 31992621 hsa-mir-889 Tuberculosis MiR-889 inhibited autophagy via posttranscriptional suppression of TWEAK expression to maintain mycobacterial survival in granulomas. +lncRNA target 31992303 hsa-mir-125a Glioma CONCLUSIONS: Our findings suggest that circ-MAPK4 is a critical player in glioma cell survival and apoptosis via p38/MAPK signaling pathway through modulation of miR-125a-3p, which can serve as a new therapeutic target for treatment of gliomas. +lncRNA target 31991700 hsa-mir-125a Fragile X Syndrome Regulation of miR-125a has been associated with type I metabotropic glutamate receptor signaling (mGluR), which has been explored as a treatment target for FXS, reinforcing the possibility that urine miR-125a may provide a novel biomarker for FXS. +genetics_GWAS 31991575 hsa-mir-1229 Alzheimer Disease 3p, and furthermore, that the AD-associated SNP rs2291418 pre-miR-1229 changes the equilibrium between these structures. +genetics_overexpression_promote 31991386 hsa-mir-195 Non-alcoholic Fatty Liver Disease CONCLUSION: Overexpression of miR-195 can reduce the Th17/Treg ratio to maintain Th17/Treg balance by inhibiting CD40 expression in rats with NAFLD. +other 31991160 hsa-mir-126 Hypertension Training upregulated microRNA-126 expression (+13.1%), prevented VEGF (+61.4%), p-AKT/AKT (+37.7%), Bcl-2 (+7.7%) decrease and caspasecleaved (-23.1%) increase associated with CD (+54.7%) reduction and hypertension prevention. +circulation_biomarker_diagnosis_up 31991160 hsa-mir-126 Microvascular Rarefaction MiRNA-126 upregulation, induced by training, plays a role in controlling microcirculation, which may be a potential target against DEX-induced microvascular rarefaction. +genetics_GWAS 31991106 hsa-mir-15b Diabetic Nephropathies miR-15b-5p has the potential to predict kidney injury in DN. Blocking the miR-15b-5p epigenetic regulatory network could be a potential therapeutic strategy to prevent mesangial apoptosis in DN. +other 31990992 hsa-mir-199a Reperfusion Injury However, whether miR-199a is involved in regulating neuronal survival during cerebral ischaemia/reperfusion injury remains unknown. In this study, we aimed to explore the biological role of miR-199a-5p in regulating neuronal injury induced by oxygen-glucose deprivation/reoxygenation (OGD/R), an in vitro cellular model of cerebral ischaemia and reperfusion injury. +lncRNA target 31990904 hsa-mir-524 Ameloblastoma 5p can participate in the tumor microenvironment of AB by targeting the IL-33/ST2 axis. +other 31990371 hsa-mir-182 Acquired Immunodeficiency Syndrome CONCLUSION: Together, TNF, IL-4 and miR-182 may represent circulatory biomarkers of VL-HIV co-infection. +genetics_overexpression_promote 31990059 hsa-mir-876 Colorectal Neoplasms 5p overexpression effectively repressed the malignant behaviours of colorectal cancer cells, including cell proliferation, colony formation, and invasion. +transcription factor target 31990036 hsa-mir-101 Vascular Diseases The modulation of miR3p and TET2 expression levels may serve as a potential target for therapeutic strategies for atherosclerosis. +circulation_biomarker_diagnosis_ns 31990029 hsa-mir-34a Breast Neoplasms In order to transfect nucleic acids into MDA-MB-231 cells in a low-cost and non-viral manner for further breast cancer gene therapy studies, we explored ultrasound targeted microbubble destruction (UTMD) technology and evaluated the efficiency and safety of the delivery of plasmid encoding enhanced green fluorescent protein (pEGFP) and a microRNA-34a (miR-34a) mimic by UTMD. +other 31989677 hsa-mir-4516 Renal Insufficiency, Chronic Furthermore, miR-4516 and PrP(C) could be key molecules for enhancing the regenerative potential of MSCs in ischemic diseases. +lncRNA target 31989667 hsa-mir-185 Colonic Neoplasms The present study suggests that silencing UCA1 may inhibit the invasion, migration, epithelial-mesenchymal transformation and tumour formation of colon cancer by upregulating miR +other 31989062 hsa-mir-548n Breast Neoplasms The network (lncRNA--> miRNA--> mRNA) is promising for the identification of carcinoma associated genes and apoptosis signaling path highlighting the potential roles of LINC01087, hsa-miR548n, AKT1 gene which may play crucial role in proliferation. +other 31989062 hsa-mir-548 Breast Neoplasms We integrated miRNA and mRNA (hsa-miR-548 and AKT1) expression profiles with curated regulations with lncRNA (LINC01087) which has not been previously associated with any breast cancer type, using different computational tools. +other 31989001 hsa-mir-503 Diabetic Angiopathies In this work, we explored the role of miR-503/Apelin-12 in diabetic angiopathy (DA) in vitro. +lncRNA target 31989001 hsa-mir-503 Alzheimer Disease In this work, we explored the role of miR-503/Apelin-12 in diabetic angiopathy (DA) in vitro. CONCLUSION: In HG-induced microvascular cells injury, miR-503/Apelin-12 enhances inflammation and oxidative stress by regulating JNK and p38MAPK pathway, suggesting a potential therapeutic target for DA. +lncRNA target 31988477 hsa-mir-15a Multiple Myeloma Altogether, our finding provides the preclinical rationale to support the oligo-single-stranded DNA mimic of hsa-miR-15a with LNA modification, which is a promising tool for the therapy of both MM and other tumors with miR-15a downregulation. +other 31988469 hsa-mir-155 Abortion, Spontaneous The immune-regulatory microRNA miR-155 is reduced in recurrent miscarriage, suggesting that miR-155 contributes to immune tolerance in pregnancy. +genetics_GWAS 31988469 hsa-mir-155 Ataxia Neuropathy Spectrum Thus miR-155 is a key regulator of immune adaptation to pregnancy and is necessary for sufficient Tregs to achieve robust pregnancy tolerance and protect against fetal loss. +transcription factor target 31988048 hsa-mir-125a Insulin Resistance These data led us to conclude that dysregulated miR-125a expression augments the development of obesity-induced IR and that miR-125a might serve as a therapeutic target for the development of new drug(s) in the clinical management of metabolic diseases. +transcription factor target 31988048 hsa-mir-125a Obesity These data led us to conclude that dysregulated miR-125a expression augments the development of obesity-induced IR and that miR-125a might serve as a therapeutic target for the development of new drug(s) in the clinical management of metabolic diseases. +transcription factor target 31987844 hsa-mir-133 Lupus Nephritis Our current study was designed to test the role of miR-133 and its potential target in LN. +lncRNA target 31987833 hsa-mir-575 Cerebral Hemorrhage Moreover, our results reveal that microRNA-575 directly suppressed PTEN to promote M2 microglial polarization and mediate the neuroprotective effect of l-lysine in ICH injury. Together, our results suggest that l-lysine confers neuroprotection after ICH injury through enhancing M2 microglial polarization and reducing inflammatory response, which is mediated by microRNA-575 upregulation and subsequent PTEN downregulation. +other 31987188 hsa-mir-21 Liver Neoplasms The level of miRNA-21, miRNA-122, and miRNA-223 are always elevated when liver cancer is present at an early stage. +other 31987188 hsa-mir-122 Liver Neoplasms The level of miRNA-21, miRNA-122, and miRNA-223 are always elevated when liver cancer is present at an early stage. +other 31987188 hsa-mir-223 Liver Neoplasms The level of miRNA-21, miRNA-122, and miRNA-223 are always elevated when liver cancer is present at an early stage. +genetics_knock down_promote 31987067 hsa-mir-155 Squamous Cell Carcinoma of Head and Neck Furthermore, luciferase reporter gene assay combined with cellular functional experiments demonstrated that HOXA11-AS functioned as a molecular sponge for miR-155, and inhibition of miR-155 attenuated the suppressive effect of HOXA11-AS knockdown on the aggressive phenotype in HSCC. +other 31986951 hsa-mir-21 Asthma It can be concluded that miRNA-21 and miRNA-155 are potential non-invasive biomarkers in the diagnosis of eosinophilic asthma and its response to therapy. +other 31986951 hsa-mir-155 Asthma It can be concluded that miRNA-21 and miRNA-155 are potential non-invasive biomarkers in the diagnosis of eosinophilic asthma and its response to therapy. +circulation_biomarker_diagnosis_up 31986893 hsa-mir-370 Leukemia, Myelogenous, Chronic, BCR-ABL Positive 3p has markedly decreased in the peripheral blood mononuclear cells (PBMCs) of patients with CML and in cell lines. +transcription factor target 31986891 hsa-mir-140 Glioma 5p exerted its inhibitory effects on proliferation, migration and invasion in glioma cells through downregulating GLUL. +transcription factor target 31986487 hsa-mir-106b Breast Neoplasms CONCLUSION: Overall, our results proved that miR-106b-5p promoted the metastasis of breast cancer by suppressing CNN1 and activating Rho/ROCK1 pathway. +other 31986444 hsa-mir-146a ankylosing spondylitis 1 MiR-146a and miR-223 were significantly decreased (p = 0.0005, p = 0.0161, respectively) and increase in miR-21 (p = 0.0002) was observed in AS patients with MetS compared to AS patients without MetS. +other 31986444 hsa-mir-223 ankylosing spondylitis 1 MiR-146a and miR-223 were significantly decreased (p = 0.0005, p = 0.0161, respectively) and increase in miR-21 (p = 0.0002) was observed in AS patients with MetS compared to AS patients without MetS. +genetics_knock down_promote 31986414 hsa-mir-206 Medulloblastoma The functional experiments showed that HOTAIR knockdown suppressed medulloblastoma cell proliferation, tumor growth, migration and invasion, and promoted cell apoptosis via the modulation of the miR-1/miR +genetics_knock down_promote 31986414 hsa-mir-1 Medulloblastoma The functional experiments showed that HOTAIR knockdown suppressed medulloblastoma cell proliferation, tumor growth, migration and invasion, and promoted cell apoptosis via the modulation of the miR-1/miR +genetics_knock down_promote 31986411 hsa-mir-200b Prostatic Neoplasms Importantly, miR-200b-3p/200c-3p or XBP1 knockdown inhibited PCa cell proliferation and promoted cell apoptosis and these inhibitory roles could be largely restored by PRKAR2B, suggesting that PRKAR2B is a functional mediator of miR-200b-3p, miR-200c-3p, and XBP1 in PCa. +other 31986411 hsa-mir-200c Prostatic Neoplasms Notably, miR-200b-3p and miR-200c-3p expression were significantly downregulated in metastatic CRPC and negatively correlated with the expression level of PRKAR2B in PCa tissues. +genetics_knock down_suppress 31986409 hsa-mir-145 Adenocarcinoma of Lung 5p/ABCC1 pathway mediated chemotherapy resistance induced by circPVT1 knockdown in LAD cells. +lncRNA target 31986125 hsa-mir-34a Pancreatic Carcinoma Thus, we have identified a key target (SERPINE1) of the TP53/miR-34a axis that may serve as a potential biomarker for early detection of pancreatic cancer. +transcription factor target 31986004 hsa-mir-146a Prostatic Neoplasms Here, we report a pH/ATP-activated nanocomplexes for increasing cytosolic delivery of miR146a which can effectively inhibit the expression of epidermal growth factor receptor (EGFR) in AIPC. +lncRNA target 31985779 hsa-mir-128 Peri-Implantitis Collectively, these results indicate that miR-128 promotes osteogenic differentiation of rBMSCs by targeting DKK2, which may provide a promising approach to the treatment of peri-implantitis. +genetics_knock down_promote 31985027 hsa-mir-20b Nasopharyngeal Carcinoma Moreover, circCTDP1 directly interacted with microRNA (miR)320b based on bioinformatics prediction and dual luciferase assay, and transfection with an miR320b inhibitor reversed the effects of circCTDP1 knockdown on NPC cells. Furthermore, circCTDP1/miR320b promoted NPC progression by regulating the expression of homeobox A10 (HOXA10). +lncRNA target 31985024 hsa-mir-137 Cholangiocarcinoma Restoring the expression of WNT2B notably reversed the inhibitory effect of miR137 on CCA cells. +other 31985019 hsa-mir-19a Reperfusion Injury IPC promoted miR19a. +lncRNA target 31985019 hsa-mir-17 Reperfusion Injury APC promoted miR173p and suppressed miR27a. +lncRNA target 31985019 hsa-mir-27a Reperfusion Injury APC promoted miR173p and suppressed miR27a. +genetics_overexpression_suppress 31985002 hsa-mir-93 Uterine Cervical Neoplasms Overexpression of MCM3AP-AS1 led to down-regulation of miR-93, while silencing of MCM3AP-AS1 played an opposite role in CSCC cells. CONCLUSIONS: Therefore, MCM3AP-AS1 may inhibit cell proliferation in CSCC by down-regulating miRNA-93. +genetics_overexpression_promote 31984757 hsa-mir-485 Colorectal Neoplasms Functional study revealed that overexpression of miR +other 31984680 hsa-mir-361 Colorectal Neoplasms 3p and up-regulating SH2B1. +genetics_GWAS 31984574 hsa-mir-27a Stomach Neoplasms CONCLUSIONS: We found that the epigenetically suppressed TFPI-2 compromised sponging effects with respect to miR-27a-3p in gastric cancer, which consequently and mechanistically contributed to the tumor biology of gastric cancer. +other 31984571 hsa-mir-222 Chemical and Drug Induced Liver Injury CONCLUSION: Early levels of HDmiR-122 and CDmiR-222, in perfusate and/or bile, are predictive of excretory functions and hepato-cholangiocellular injury after 6 hours NMP. +other 31984571 hsa-mir-122 Chemical and Drug Induced Liver Injury CONCLUSION: Early levels of HDmiR-122 and CDmiR-222, in perfusate and/or bile, are predictive of excretory functions and hepato-cholangiocellular injury after 6 hours NMP. +genetics_knock down_promote 31983569 hsa-mir-503 Carcinoma, Non-Small-Cell Lung In conclusion, knockdown of MIR503HG suppressed proliferation and promoted apoptosis of NSCLC cells through regulating miR +genetics_knock down_suppress 31983431 hsa-mir-335 Ovarian Neoplasms Our results showed both Sp1 knockdown and mithramycin A increased miR-335 expression in ovarian cancer cell lines. +genetics_GWAS 31983284 hsa-mir-627 Stomach Neoplasms There were no links between age, sex, tumour type, distant metastasis, and tumour stages and the miR-627 polymorphism in gastric cancer patients.Conclusion: Presence of the C SNP in miR-627 rs2620381 in linked with gastric cancer, and may be important in pathogenesis. +other 31983127 hsa-mir-34a Esophageal Squamous Cell Carcinoma The anti-tumor effect of miR-34a is possibly dependent on the regulation of cell-cycle regulator E2F5. +lncRNA target 31983121 hsa-mir-3175 Glioma PURPOSE: This study aimed to investigate the expressions of microRNA (miR)-3175 and miR-134 in gliomas and their effects on the proliferation and invasion of U251 glioma cells. CONCLUSION: Downregulating expression of miR-3175 or facilitating expression of miR-134 could inhibit the proliferative and invasive activity of glioma cells and facilitate their apoptosis by inhibiting the activation of PI3K signaling pathway. +lncRNA target 31983121 hsa-mir-134 Glioma PURPOSE: This study aimed to investigate the expressions of microRNA (miR)-3175 and miR-134 in gliomas and their effects on the proliferation and invasion of U251 glioma cells. CONCLUSION: Downregulating expression of miR-3175 or facilitating expression of miR-134 could inhibit the proliferative and invasive activity of glioma cells and facilitate their apoptosis by inhibiting the activation of PI3K signaling pathway. +other 31983116 hsa-mir-210 Laryngeal Neoplasms 3p. +lncRNA target 31983112 hsa-mir-124 Carcinoma, Hepatocellular PURPOSE: To investigate the expression level of circ_0000502 in hepatocellular carcinoma (HCC), and to further explore whether it can promote the malignant progression of HCC by targeting and binding to microRNA (miR)-124. +other 31983109 hsa-mir-497 Breast Neoplasms Increased LrcRNA GACAT3 in breast cancer cells could downregulate the expression of miR-497, down-regulate Capsase 9 and up-regulate Bcl-2 to promote proliferation and anti-apoptosis of breast cancer cells. +lncRNA target 31983104 hsa-mir-375 Ovarian Neoplasms CONCLUSION: miR-375 may prove to be an important therapeutic target in ovarian cancer and warrants further research endeavors. +lncRNA target 31983096 hsa-mir-532 Carcinoma, Non-Small-Cell Lung 3p/FOXP3 axis might be a potential therapeutic target for the treatment of NSCLC. +lncRNA target 31983095 hsa-mir-200a Carcinoma, Non-Small-Cell Lung CONCLUSIONS: This study suggests that lncRNA-ATB promotes the apoptosis of NSCLC cells through inhibiting the expression of miR-200a and reversely promoting the expression of beta-catenin. +lncRNA target 31983094 hsa-mir-375 Adenocarcinoma of Lung Furthermore, it was discovered that ROR1-AS1 acted as a competing endogenous RNA via sponging miR-375 in LAC. CONCLUSIONS: These results suggested that ROR1-AS1 could act as a sponge for miR-375 and promo//e cell migration and invasion through suppressing the process of EMT in LAC, which may offer a potential therapeutic target in LAC. +transcription factor target 31982878 hsa-mir-144 Coronary Disease miR-144 acts as a proliferation inhibitor in cardiomyocytes via the TBX1/JAK2/STAT1 axis and is therefore a potential novel therapeutic target for CHD treatment. +genetics_overexpression_promote 31982825 hsa-mir-152 Cerebral Hemorrhage Mechanistically, miR-152 significantly inhibited ICH-induced TXNIP expression, and its overexpression blocked the interaction between TXNIP and NOD-like receptor pyrin domain containing 3(NLRP3), thus inhibiting NLRP3-driven inflammasome activation to attenuate neuroinflammation in vivo and in vitro. +lncRNA target 31982774 hsa-mir-892a Squamous Cell Carcinoma of Head and Neck Melatonin reduced the drug resistance and promoted the apoptosis of VCR-resistant oral cancer cells through the upregulation of microRNA-892a (miR-892a) and miR-34b-5p expressions. +lncRNA target 31982774 hsa-mir-34b Squamous Cell Carcinoma of Head and Neck Melatonin reduced the drug resistance and promoted the apoptosis of VCR-resistant oral cancer cells through the upregulation of microRNA-892a (miR-892a) and miR-34b-5p expressions. +lncRNA target 31982726 hsa-mir-1299 Stomach Neoplasms Results of recue assays validated that RHPN1-AS1/miR-1299/ETS1 positive feedback loop aggravated the malignant behaviors of GC, revealing RHPN1-AS1 as a latent effective target for the treatment of GC patients. +lncRNA target 31982471 hsa-mir-21 Hypoxia-Ischemia, Brain The expression of lncRNA Gas5 and microRNA-21 (miR-21) was altered in neurons to elucidate their effects in ischaemic brain injury and to identify the interactions among lncRNA Gas5, miR-21 and Pten. These findings demonstrate that lncRNA Gas5 increases miR-21 and activates Pten, contributing to the development of ischaemic brain injury, supporting the silencing of lncRNA Gas5 as a possible therapeutic target for the treatment of ischaemic brain injury. +lncRNA target 31982428 hsa-mir-145a Cardiomegaly Meanwhile, Mhrt promotes the expression of KLF4 through direct binding to miR-145a-5p or inhibiting phosphorylation of KLF4 by forming a complex with KLF4 to prevent the binding of ERK and KLF4, thereby inhibiting myocardin expression and the development of myocardial hypertrophy. +lncRNA target 31982134 hsa-mir-106b Cardiomyopathies In mechanism, we demonstrated experimentally that Fendrr directly targeting miR-106b, by which the lncRNA promotes cardiac fibrosis (indicated by the elevation of Col1a1, Col3a1, CTGF and ACTA2 expression) in a miR-106b mediated manner. Collectively, our findings highlight the axis of Fendrr/miR-106b/Samd3 in the pathogenesis of cardiac fibrosis, which may be a promising target for clinical intervention target of cardiac fibrosis. +other 31981974 hsa-mir-21 Pyoderma Gangrenosum FINDINGS: miR-21 was decreased, whilst XIST and IL-12A were increased in the bronchoalveolar lavage fluid of PGD patients after lung transplantation. INTERPRETATION: In summary, lncRNA XIST upregulates IL-12A by binding to miR-21, thereby inducing NET formation and accelerating PGD after lung transplantation. +lncRNA target 31981466 hsa-mir-543 Lung Neoplasms All these findings concluded that LINC-PINT exerted crucial biological roles in NSCLC through sponging miR-543 and inducing PTEN. +genetics_overexpression_promote 31981455 hsa-mir-200a Osteosarcoma CD8(+) T cells co-cultured with microRNA-200a-overexpressing osteosarcoma cells showed reduced survival, proliferation, and secretion of granzyme B and perforin. +exosome 31981320 hsa-mir-92a Myocardial Infarction We found that miR-92a was significantly (P < 0.05) upregulated in cardiomyocyte-derived exosomes and in fibroblasts isolated after MI compared with SHAM conditions (n >/= 6/group). +other 31981240 hsa-mir-922 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: CCHE1 increases the expression of PAK2 to promote the progression of OSCC by competitively binding to miR-922 in OSCC cells. +circulation_biomarker_diagnosis_ns 31980721 hsa-mir-142 Bipolar Disorder We found that serum expression levels of miR +circulation_biomarker_diagnosis_ns 31980721 hsa-mir-145 Bipolar Disorder We found that serum expression levels of miR +circulation_biomarker_diagnosis_ns 31980721 hsa-mir-23b Bipolar Disorder We found that serum expression levels of miR +circulation_biomarker_diagnosis_ns 31980721 hsa-mir-221 Bipolar Disorder We found that serum expression levels of miR +circulation_biomarker_diagnosis_ns 31980721 hsa-mir-370 Bipolar Disorder We found that serum expression levels of miR +circulation_biomarker_diagnosis_ns 31980721 hsa-mir-7 Bipolar Disorder We found that serum expression levels of miR +circulation_biomarker_diagnosis_ns 31980676 hsa-mir-885 Cystic Fibrosis There is a significant increase in miR5p in plasma of females versus males with CF under six years of age. +other 31980446 hsa-mir-130b Stomach Neoplasms MIR130b expression in human gastric tissue including gastric cancer and patient sera was determined by qPCR and in situ hybridisation. Moreover, MIR130b colocalised with SLFN12L, a human homologue of SLFN4, in gastric cancers. +epigenetics 31980031 hsa-mir-29b Hyperalgesia CONCLUSION: Collectively, the results indicated that CFA leads to the upregulation of miR-29b level, which represses the expression of DNMT3b, enhances the demethylation of the NGF gene promoter region, and promotes the binding of C/EBPalpha with the NGF gene promoter, thus results in the upregulation of NGF gene expression and maintenance of chronic inflammatory pain. +other 31979011 hsa-mir-133b Sarcopenia In conclusion, our findings highlight a nutrient-miR-133b/miR-206 pathway having a potential role in the age-related muscle decline. +other 31979011 hsa-mir-206 Sarcopenia In conclusion, our findings highlight a nutrient-miR-133b/miR-206 pathway having a potential role in the age-related muscle decline. +lncRNA target 31978895 hsa-mir-133b Cholangiocarcinoma In addition, malignant phenotypes of CCA promoted by ZEB1-AS1 dysregulation were rescued separately through interfering miR-133b and HOXB8, suggesting AR/ZEB1-AS1/miR-133b/HOXB8 exerted crucial functions in tumorigenesis and progression of CCA. +other 31978557 hsa-mir-9 Arthritis, Rheumatoid NF-kappaB1-RANKL pathway in RA-FLS, further, miR-9 ameliorated inflammatory arthritis in vivo which propose therapeutic implications of miR- 9 in RA. +transcription factor target 31978512 hsa-mir-135a Neuralgia Furthermore, we found ciRS-7 regulates neuropathic pain progress by sponging to miR-135a-5p. In CCI rats, inhibiting miR-135a-5p decreases the level of autophagy and inflammation and alleviates neuropathic pain. +other 31978117 hsa-mir-122 Infant, Small For Gestational Age miR5p during childhood could identify SGA subjects at higher risk of developing insulin resistance and, eventually, type 2 diabetes in adulthood but further studies are needed to confirm it. +genetics_overexpression_promote 31977154 hsa-mir-195 Prostatic Neoplasms Overexpression of miR-195 significantly suppressed cell proliferation, migration, invasion and epithelial-mesenchymal transition (increased E-cadherin and decreased N-cadherin) in PCa cells. +transcription factor target 31976858 hsa-mir-29a Colorectal Neoplasms Interestingly, miR-29a-3p and its targets belong to a selective biomarker that is able to identify colorectal cancer patients who are responding to anti-angiogenic treatments. +other 31976830 hsa-mir-1293 Adenocarcinoma of Lung Three of them, hsa-miR-1293, hsa-miR-490 and hsa-miR- 5571, were also significantly associated with the survival of the LUAD patients. CONCLUSION: Hsa-miR-1293, hsa-miR-490 and hsa-miR-5571 can be potentially used as novel biomarkers for the prognosis prediction of LUAD. +other 31976830 hsa-mir-490 Adenocarcinoma of Lung Three of them, hsa-miR-1293, hsa-miR-490 and hsa-miR- 5571, were also significantly associated with the survival of the LUAD patients. CONCLUSION: Hsa-miR-1293, hsa-miR-490 and hsa-miR-5571 can be potentially used as novel biomarkers for the prognosis prediction of LUAD. +other 31976830 hsa-mir-5571 Adenocarcinoma of Lung Three of them, hsa-miR-1293, hsa-miR-490 and hsa-miR- 5571, were also significantly associated with the survival of the LUAD patients. CONCLUSION: Hsa-miR-1293, hsa-miR-490 and hsa-miR-5571 can be potentially used as novel biomarkers for the prognosis prediction of LUAD. +genetics_overexpression_promote 31976317 hsa-mir-486 Carcinoma, Hepatocellular 5p overexpression in HCC cell lines at both mRNA and protein level, and overexpression of CBL counteracted the inhibitory effects of miR +other 31976313 hsa-mir-195 Lung Neoplasms 5p may act as a biomarker that contributes to the diagnosis of lung cancer and the detection of its high-risk population. +circulation_biomarker_diagnosis_up 31976033 hsa-mir-375 Myocardial Infarction, Acute Plasma microRNA-375 may serve as an essential clinical biomarker for diagnosis of early-stage AMI. +lncRNA target 31975615 hsa-mir-101 Liver Cirrhosis In conclusion, Sch B can directly target miR-101 to suppress liver fibrosis. +lncRNA target 31975570 hsa-mir-101 Carcinoma, Renal Cell 5p/DONSON axis and its modulated replisome genes might be a novel diagnostic and therapeutic target for ccRCC. +genetics_overexpression_promote 31975504 hsa-mir-92b Carcinoma, Renal Cell Overexpression of miR-92b-3p decreased the protein expression of TSC1 and enhanced the downstream phosphorylation of p70S6 kinase, suggesting that the mTOR signaling pathway was activated by miR-92b-3p in RCC cells. +lncRNA target 31975433 hsa-mir-210 Prostatic Neoplasms Neural cell adhesion molecule (NCAM) is identified as a target of miR-210, providing a biological mechanism whereby hypoxia-induced miR-210 expression can contribute to prostate cancer. +genetics_overexpression_promote 31975384 hsa-mir-4510 Gastrointestinal Stromal Tumors In addition, overexpression of miR-4510 suppressed GIST cell proliferation, migration, and invasion. +genetics_knock down_promote 31975383 hsa-mir-2113 Carcinoma, Hepatocellular Lost-of-function assays found that eIF4AIII knockdown, WD (Trp-Asp [tryptophan and asparaginic acid]) repeat domain 66 (WDR66) silence or miR-2113 promotion repressed cell proliferation, migration, and epithelial-mesenchymal transition (EMT) process in HCC. +other 31975381 hsa-mir-519a-2 Carcinoma, Hepatocellular Three miRNAs (mir1, mir-516a-1, mir-519a-2) were negatively associated with overall survival on the basis of the Kaplan-Meier analysis and the 3-miRNA signature was significant for the prognostic assessment of HCC. +other 31975381 hsa-mir-516a-1 Carcinoma, Hepatocellular Three miRNAs (mir1, mir-516a-1, mir-519a-2) were negatively associated with overall survival on the basis of the Kaplan-Meier analysis and the 3-miRNA signature was significant for the prognostic assessment of HCC. +other 31975381 hsa-mir-512-1 Carcinoma, Hepatocellular Three miRNAs (mir1, mir-516a-1, mir-519a-2) were negatively associated with overall survival on the basis of the Kaplan-Meier analysis and the 3-miRNA signature was significant for the prognostic assessment of HCC. +exosome 31974910 hsa-mir-933 Dyspepsia Our results indicated that hsa-miR-933 was significantly downregulated in FD compared with HCs (0.317 /- 0.205-fold, P = 0.0317). CONCLUSIONS: Exosomal hsa-miR-933 in gastric juice could be a candidate biomarker for FD. +transcription factor target 31974624 hsa-mir-421 Vitiligo However, there is no report to date on the role of miR421 in vitiligo development. These data collectively suggest that miR421 may serve as a new treatment target in vitiligo development. +transcription factor target 31974607 hsa-mir-210 Hypoxia Hypoxia led to elevated oxidative stress, enhanced cell apoptosis and upregulated miR210 expression levels in HL1 cells, while SWT could alleviate hypoxiainduced cell injury and further promote miR210 expression. +other 31974607 hsa-mir-210 Heart Injuries SWT could exert cardioprotective effects against hypoxiainduced cardiac injury by modulating miR210. +lncRNA target 31974341 hsa-mir-126 Burns Collectively, our study revealed that HOTAIR/miR-126/SCEL axis contributes to burn wound healing through mediating angiogenesis. +genetics_knock down_promote 31974197 hsa-mir-21 Ataxia Neuropathy Spectrum Moreover, significant loss of HSC quiescence and long-term reconstituting ability are observed in the absence of miR-21. +other 31973816 hsa-mir-145 Sjogren's Syndrome Taken together, this study improves the mechanistic understanding of fibrotic remodelling in SSc by identifying a hitherto unknown miR-145/KLF4 pathway mediating the fibrogenic XT-I induction. +other 31973814 hsa-mir-297 Myocardial Ischemia In the present study, we examined a circular RNA, hsa_circ_0007623, which is highly expressed in hypoxia-induced human umbilical vein endothelial cells (HUVECs) and can act as a sponge for miR-297, which is involved in cardiac repair after acute myocardial ischemia. We concluded that hsa_circ_0007623 can bind to miR-297, promote cardiac repair after acute myocardial ischemia, and protect cardiac function. +exosome 31973730 hsa-mir-455 Hepatitis CONCLUSIONS: miR3p-enriched exosomes derived from hUC-MSCs are a promising therapy for acute inflammatory liver injury. +circulation_biomarker_diagnosis_ns 31973730 hsa-mir-455 Liver Diseases 3p could attenuate macrophage infiltration and local liver damage and reduce the serum levels of inflammatory factors, thereby improving liver histology and systemic disorder. +circulation_biomarker_diagnosis_ns 31973730 hsa-mir-455 Chemical and Drug Induced Liver Injury 3p could attenuate macrophage infiltration and local liver damage and reduce the serum levels of inflammatory factors, thereby improving liver histology and systemic disorder. +genetics_overexpression_promote 31973537 hsa-mir-506 Ovarian Neoplasms Further investigation revealed that overexpression of SIRT1 could promote cell viability as well as inhibit cell apoptosis, showing the reversed effect on OC progression compared to miR +genetics_knock down_suppress 31973536 hsa-mir-144 Glioma 3p knockdown. +genetics_knock down_promote 31973533 hsa-mir-17 Thyroid Neoplasms 5p or overexpression of PTEN suppressed cell proliferation and autophagy but promoted apoptosis in thyroid cancer cells. +lncRNA target 31972611 hsa-mir-346 Cholangitis, Sclerosing, Primary RESULTS: An increased expression of miR-346 in the ascending colon of PSC-UC was observed (P < 0.001 vs all groups). DISCUSSION: The upregulation of miRNA-346 in the colon of patients with PSC may be responsible for the disturbance of VDR and TNF-alpha signaling pathway, which could result in an inadequate suppression of neoplasia. +lncRNA target 31972363 hsa-mir-133a Reperfusion Injury In conclusion, PTX has the potential to alleviate cardiac injury and increase the number of c-kit cells following ischemia-reperfusion in the rat model via modulation of lncRNA-00654 and miR-133a-SOX5 mRNA expressions. +lncRNA target 31972363 hsa-mir-133a Heart Injuries In conclusion, PTX has the potential to alleviate cardiac injury and increase the number of c-kit cells following ischemia-reperfusion in the rat model via modulation of lncRNA-00654 and miR-133a-SOX5 mRNA expressions. +lncRNA target 31972361 hsa-mir-593 Rectal Neoplasms To sum up, LINC00461 mediates cisplatin resistance of rectal cancer by targeting miR +lncRNA target 31972307 hsa-mir-574 Stomach Neoplasms 5p in gastric cancer cells promoted angiogenesis via enhancing phosphorylation of p44/42 MAPKs by miR +lncRNA target 31972179 hsa-mir-326 Cardiomegaly In brief, our study unveiled that miR-326 targets MDK to regulate the progression of cardiac hypertrophy through blocking JAK/STAT and MAPK signaling pathways, indicating that targeting miR-326 as a potential approach for cardiac hypertrophy treatment. +epigenetics 31972160 hsa-mir-34b Colitis-Associated Neoplasms Collectively, our findings demonstrate that intracellular inflammation and DNA hypermethylation suppress miR-34b-5p expression, which limits its inhibitory effect on c-MYC and initiates the downstream events, including the induction of CRL4(DCAF4) E3 ligase activity. +epigenetics 31972160 hsa-mir-34b Inflammation Collectively, our findings demonstrate that intracellular inflammation and DNA hypermethylation suppress miR-34b-5p expression, which limits its inhibitory effect on c-MYC and initiates the downstream events, including the induction of CRL4(DCAF4) E3 ligase activity. +other 31972158 hsa-mir-218 Ischemia Murine renal artery-derived EPCs (CD34(+)/CD105(-)) showed down-regulation of mmu-Mir218-5p/U6 RNA ratio after ischemic injury, while in human renal arteries, MIR218-5p expression was up-regulated after ischemic injury. +circulation_biomarker_diagnosis_up 31972053 hsa-mir-215 Pre-Eclampsia 5p in plasma of PE patients compared with the control group; nonetheless, there is still no knowledge of the mechanism of miR +other 31971908 hsa-mir-150 Depression RESULTS miR5p, miR-29a-3p, and miR-30a-5p were associated with increased SCD risk (odds ratios and 95% confidence intervals: 2.03 [1.12 to 3.67]; p = 0.02; 1.93 [1.07 to 3.50]; p = 0.02; 0.55 [0.31 to 0.97]; p = 0.04, respectively, for third vs. +other 31971908 hsa-mir-150 Congenital central hypoventilation syndrome RESULTS miR5p, miR-29a-3p, and miR-30a-5p were associated with increased SCD risk (odds ratios and 95% confidence intervals: 2.03 [1.12 to 3.67]; p = 0.02; 1.93 [1.07 to 3.50]; p = 0.02; 0.55 [0.31 to 0.97]; p = 0.04, respectively, for third vs. +other 31971908 hsa-mir-29a Congenital central hypoventilation syndrome RESULTS miR5p, miR-29a-3p, and miR-30a-5p were associated with increased SCD risk (odds ratios and 95% confidence intervals: 2.03 [1.12 to 3.67]; p = 0.02; 1.93 [1.07 to 3.50]; p = 0.02; 0.55 [0.31 to 0.97]; p = 0.04, respectively, for third vs. +other 31971908 hsa-mir-29a Depression RESULTS miR5p, miR-29a-3p, and miR-30a-5p were associated with increased SCD risk (odds ratios and 95% confidence intervals: 2.03 [1.12 to 3.67]; p = 0.02; 1.93 [1.07 to 3.50]; p = 0.02; 0.55 [0.31 to 0.97]; p = 0.04, respectively, for third vs. +lncRNA target 31971830 hsa-mir-1293 Carcinoma, Renal Cell In sum, miR-1293 can regulate the viability, invasion, and migration of RCC tumor cells by targeting HAO2, suggesting that miR-1293 can be used as a new biomarker for clinical treatment of RCC. +other 31971654 hsa-mir-502 Urinary Bladder Neoplasms 5p-mediated regulatory network is critical in bladder cancer; this network may be useful in the development of more effective therapies against bladder cancer. +genetics_knock down_promote 31971633 hsa-mir-518b Prostatic Neoplasms Moreover, rescued-function assays revealed that miR-518b inhibition or ACTN4 upregulation reversed the repressive effect of HOXA11-AS knockdown on PCa progression. CONCLUSIONS: CTCF-induced upregulation of HOXA11-AS facilitates PCa progression via miR-518b/ACTN4 axis, providing a new target for PCa treatment. +lncRNA target 31971049 hsa-mir-424 Carcinoma, Endometrioid Interestingly, the over-expression of CPEB2 could reverse the changes of osthole-induced proliferation and apoptosis of Ishikawa and KLE cells.Conclusions: In summary, we provided first evidences that osthole inhibited proliferation and induced apoptosis through up-regulating miR-424 to inhibit expression of CPEB2 in EC. +genetics_overexpression_promote 31970934 hsa-mir-612 Uterine Cervical Neoplasms NOB1 overexpression partially reversed the inhibitory effects of miR-612 overexpression in cervical cancer cells. +lncRNA target 31970876 hsa-mir-20a Carcinoma, Hepatocellular MiR-320a was a potential target of SUMO1P3, and its expression was negatively regulated by SUMO1P3 in HCC SUMO1P3 could activate Wnt/beta-catenin pathway, which was mediated by miR-320a. SUMO1P3 enhances Wnt/beta-catenin pathway through sponging miR-320a, thus contributing to aggressive progression of HCC. +genetics_overexpression_promote 31970775 hsa-mir-4443 Breast Neoplasms In vivo, overexpression of miR-4443 in noninvasive BCa cells induces liver metastasis, accompanied with downregulated TIMP2, and upregulated MMP-2 in both the primary tumor and liver. +lncRNA target 31970774 hsa-mir-4282 Squamous Cell Carcinoma of Head and Neck In conclusion, the present study revealed that miR-4282 inhibited tumor progression through downregulation of ZBTB2 by targeting LIN28B in OSCC cells, indicating miR-4282 as a novel biomarker for OSC. +other 31969878 hsa-mir-146b Gastritis pylori-infected patients confirmed the up-regulation of let-7i-5p, miR-146b-5p, and 5p in gastritis, in pre-invasive lesions, and in gastric cancer. +other 31969878 hsa-let-7i Stomach Diseases pylori-infected patients confirmed the up-regulation of let-7i-5p, miR-146b-5p, and 5p in gastritis, in pre-invasive lesions, and in gastric cancer. +other 31969878 hsa-let-7i Gastritis pylori-infected patients confirmed the up-regulation of let-7i-5p, miR-146b-5p, and 5p in gastritis, in pre-invasive lesions, and in gastric cancer. +other 31969878 hsa-mir-146b hereditary diffuse gastric cancer pylori-infected patients confirmed the up-regulation of let-7i-5p, miR-146b-5p, and 5p in gastritis, in pre-invasive lesions, and in gastric cancer. +other 31969878 hsa-let-7i Carcinoma in Situ pylori-infected patients confirmed the up-regulation of let-7i-5p, miR-146b-5p, and 5p in gastritis, in pre-invasive lesions, and in gastric cancer. +other 31969878 hsa-mir-146b Stomach Diseases pylori-infected patients confirmed the up-regulation of let-7i-5p, miR-146b-5p, and 5p in gastritis, in pre-invasive lesions, and in gastric cancer. +other 31969878 hsa-mir-146b Carcinoma in Situ pylori-infected patients confirmed the up-regulation of let-7i-5p, miR-146b-5p, and 5p in gastritis, in pre-invasive lesions, and in gastric cancer. +other 31969878 hsa-let-7i hereditary diffuse gastric cancer pylori-infected patients confirmed the up-regulation of let-7i-5p, miR-146b-5p, and 5p in gastritis, in pre-invasive lesions, and in gastric cancer. +circulation_biomarker_diagnosis_ns 31969632 hsa-mir-30 Diabetes, Gestational We report this strong novel association of circulating miR3p with risk of primary caesarean delivery as a pregnancy outcome linked with poor maternal glycaemic control, strengthening the growing body of evidence for roles of diabetes-associated miRNAs in glucose homeostasis and adaptation to the complex changes related to pregnancy. +circRNA target 31969560 hsa-mir-762 Urinary Bladder Neoplasms Subsequently, we found that circFAM114A2 might increase the expression of NP63 (main isoform of TP63 in UCB) by sponging miR-762. Taken together, our results demonstrated that circFAM114A2 might serve as a competing endogenous RNA (ceRNA) of miR-762 in regulating the expression of NP63, thus suppressed UCB progression through circFAM114A2/miR-762/NP63 axis. +exosome 31969559 hsa-mir-567 Breast Neoplasms To conclude, exosomal miR-567 plays a key role in reversing trastuzumab resistance via regulating autophagy, indicating it may be a promising therapeutic target and prognostic indicator for breast cancer patients. +other 31969212 hsa-mir-224 Carcinoma, Hepatocellular RNA pull-down assay demonstrated that circular RNA circ-ITCH could sponge miR5p specifically in HCC. +other 31968402 hsa-mir-514a Choroidal Melanoma Altogether, this study unveiled the modulation axis ELF1/LUCAT1/miR-514a/b-3p/RBX1 and evidenced LUCAT1 as a promoter in CM for the first time, providing a novel insight into future treatment of CM. +other 31968402 hsa-mir-514b Choroidal Melanoma Altogether, this study unveiled the modulation axis ELF1/LUCAT1/miR-514a/b-3p/RBX1 and evidenced LUCAT1 as a promoter in CM for the first time, providing a novel insight into future treatment of CM. +genetics_knock down_suppress 31968395 hsa-mir-363 Adenocarcinoma of Lung CONCLUSIONS: XIST knockdown repressed proliferation, migration and invasion, and accelerated apoptosis of LAD cells by downregulating MDM2 expression via binding to miR +lncRNA target 31967930 hsa-mir-664b Carcinoma, Hepatocellular Conclusions: miR-664b-5p acts as a cancer suppressor through negatively regulating AKT2 expression in HepG2 and SUN-475 cells, suggesting that miR-664b-5p could be a protective target for HCC patients. +genetics_overexpression_promote 31967713 hsa-mir-195 Adenocarcinoma of Lung Overexpressed LINC00461 and HOXA10 but down-regulated miR-195 were observed in primary and metastatic lung adenocarcinoma. +transcription factor target 31967701 hsa-mir-186 Hepatoblastoma miR-186/METTL3/Wnt/beta-catenin axis might serve as novel therapeutic targets and prognostic biomarkers in HB. +circulation_biomarker_prognosis_ns 31967688 hsa-mir-99 Cerebral Infarction, Acute OBJECTIVE: The aim of the present study is to explore the potential diagnostic and prognostic value of plasma levels of miR-99 family for patients with acute cerebral infarction (ACI). +circulation_biomarker_prognosis_down 31967688 hsa-mir-99b Cerebral Infarction, Acute CONCLUSION: miR-99b was down-regulated in plasma of patients with ACI, and plasma level of miR-99b may be a potential diagnostic and prognostic marker for the diagnosis and treatment of ACI. +other 31967512 hsa-mir-137 Ovarian Neoplasms Conclusion: These results suggest that miR-137 downregulates MCL1 in ovarian cancer cells and mediates cisplatin-induced apoptosis. +circulation_biomarker_prognosis_up 31967348 hsa-mir-125b Respiratory Distress Syndrome In sepsis patients, miR-125a relative expression was positively associated with serum creatinine (Scr), chronic health evaluation (APACHE) II score, sequential organ failure assessment (SOFA) score, and miR-125b was positively associated with Scr, C-reactive protein (CRP), APACHE II score, SOFA score, and chronic obstructive pulmonary disease. +circulation_biomarker_prognosis_up 31967348 hsa-mir-125a Respiratory Distress Syndrome In sepsis patients, miR-125a relative expression was positively associated with serum creatinine (Scr), chronic health evaluation (APACHE) II score, sequential organ failure assessment (SOFA) score, and miR-125b was positively associated with Scr, C-reactive protein (CRP), APACHE II score, SOFA score, and chronic obstructive pulmonary disease. +circulation_biomarker_prognosis_up 31967348 hsa-mir-125a Sepsis In sepsis patients, miR-125a relative expression was positively associated with serum creatinine (Scr), chronic health evaluation (APACHE) II score, sequential organ failure assessment (SOFA) score, and miR-125b was positively associated with Scr, C-reactive protein (CRP), APACHE II score, SOFA score, and chronic obstructive pulmonary disease. +circulation_biomarker_prognosis_up 31967348 hsa-mir-125b Sepsis In sepsis patients, miR-125a relative expression was positively associated with serum creatinine (Scr), chronic health evaluation (APACHE) II score, sequential organ failure assessment (SOFA) score, and miR-125b was positively associated with Scr, C-reactive protein (CRP), APACHE II score, SOFA score, and chronic obstructive pulmonary disease. +lncRNA target 31966906 hsa-mir-139 Myocardial Reperfusion Injury The MiR5p has the potential of regulating cell apoptosis and cell autophagy by inhibiting AMPK/mTOR/ULK1 signaling pathway and thereby protecting against myocardial I/R injury. +genetics_knock down_promote 31966903 hsa-mir-29b Dermatitis, Atopic These findings revealed that the miR-29b/Bcl2L2 regulatory axis was involved in the pathogenesis of AD and suggested that knockdown of miR-29b might be a novel therapeutic target for AD. +transcription factor target 31966899 hsa-mir-200c Breast Neoplasms BCSCs facilitate BMI1 gene expression via inhibiting miR-200c expression, further elevating BCSCs proliferation and tumor formation potency. +lncRNA target 31966887 hsa-mir-224 Carcinoma, Hepatocellular OBJECTIVE to explore clinical value and potential targets of MicroRNA +other 31966878 hsa-mir-27a Tuberculosis In conclusion, miR-27a plays a key role in immune response to Mtb infection and intervening on miR-27a may be an effective way to treat TB. +circulation_biomarker_prognosis_up 31966849 hsa-mir-34a Osteosarcoma RESULTS: The serum miR-34a levels was significantly decreased in the serum of osteosarcoma patients compared to healthy controls (P < 0.001). +lncRNA target 31966827 hsa-mir-22 Uterine Cervical Neoplasms Taken together, we demonstrate that the miR-22 may serve as a novel therapeutic target and prognostic marker in patients with cervical cancer. +circulation_biomarker_prognosis_ns 31966826 hsa-mir-193b Colorectal Neoplasms These findings indicate that serum miR-193b serves as a promising novel prognostic biomarker for CRC. +circulation_biomarker_prognosis_up 31966825 hsa-mir-140 Colorectal Neoplasms In conclusion, our study revealed that serum miR +transcription factor target 31966816 hsa-mir-23b Colonic Neoplasms In conclusion, miR-23b is lowly expressed in colon cancer tissues and cells, and miR-23b may play an inhibitory role in the development of colon cancer through down-regulating the expression of PDE7A. +genetics_knock down_promote 31966814 hsa-mir-543 Urinary Bladder Neoplasms Notably, overexpression of miR +genetics_overexpression_promote 31966813 hsa-mir-26b Cardiomegaly Additionally, it was shown that overexpression of miR-26b attenuated autophagic responses in hypertrophic cardiomyocytes, which was confirmed by reducing Beclin-1 expression and the light chain 3(LC3)-II/LC3-I ratio. +lncRNA target 31966811 hsa-mir-483 Esophageal Neoplasms Our data showed that the miR5p/HNF4A axis affected the malignant transformation of immortalized human esophageal epithelial cells and is a potential therapeutic target for ESCC. +other 31966811 hsa-mir-483 Esophageal Squamous Cell Carcinoma However, the biological functions of miR5p in esophageal squamous cell carcinomas are not fully understood. +transcription factor target 31966797 hsa-mir-27b Colorectal Neoplasms Our findings indicated that miR-27b-3p inhibited CRC cell proliferation, migration and invasion by targeting LIMK1. +other 31966794 hsa-mir-223 Spinal Cord Injuries MicroRNAs (miRNAs) are recognized as key regulators in SCI; however, the role of miR-223 in SCI remains unclear. +lncRNA target 31966793 hsa-mir-128 Thyroid Neoplasms Notably, miRNA-128 over-expression-inhibited proliferation and induced-apoptosis of human thyroid cancer cells were partially changed following the block of CXCR4/RhoA signaling pathway by the CXCR4 inhibitor (AMD3100). +lncRNA target 31966789 hsa-mir-365 Carcinoma, Hepatocellular In conclusion, down-regulated miR-365 may contribute to the progression and metastasis of HCC via targeting multiple signaling pathways, and miR-365 may act as a novel biomarker for HCC. +lncRNA target 31966787 hsa-mir-17 Osteoarthritis 3p can be a potential therapeutic target in OA patients. +lncRNA target 31966785 hsa-mir-1 Spinal Cord Injuries Meanwhile, TGF-beta inhibitor suppressed the effects of microRNA-31 on apoptosis of in vitro model of SCI. +transcription factor target 31966782 hsa-mir-194 Atrial Fibrillation CONCLUSIONS: It is indicated that Lichen extracts could regulate the expression of atrial fibrillation-associated genes via miR5a targeting. +circulation_biomarker_diagnosis_ns 31966780 hsa-mir-25 Angina, Unstable Conclusion: The circulating levels of miRNAs (miR-21, miR-25, miR-106b, miR-126*) are significantly higher in UA patients compared with patients with NICP, and the addition of the m-HS that combined ECG, age, risk factors and troponin is useful to detect or rule out UA. +circulation_biomarker_diagnosis_ns 31966780 hsa-mir-126 Angina, Unstable Circulating miR-21, miR-25, miR-92a, miR-106b, miR-126* and miR-451 levels were measured in 98 patients with UA and 95 control subjects in the ED. Conclusion: The circulating levels of miRNAs (miR-21, miR-25, miR-106b, miR-126*) are significantly higher in UA patients compared with patients with NICP, and the addition of the m-HS that combined ECG, age, risk factors and troponin is useful to detect or rule out UA. +circulation_biomarker_diagnosis_ns 31966780 hsa-mir-21 Angina, Unstable Circulating miR-21, miR-25, miR-92a, miR-106b, miR-126* and miR-451 levels were measured in 98 patients with UA and 95 control subjects in the ED. Conclusion: The circulating levels of miRNAs (miR-21, miR-25, miR-106b, miR-126*) are significantly higher in UA patients compared with patients with NICP, and the addition of the m-HS that combined ECG, age, risk factors and troponin is useful to detect or rule out UA. +circulation_biomarker_diagnosis_ns 31966780 hsa-mir-106b Angina, Unstable Circulating miR-21, miR-25, miR-92a, miR-106b, miR-126* and miR-451 levels were measured in 98 patients with UA and 95 control subjects in the ED. Conclusion: The circulating levels of miRNAs (miR-21, miR-25, miR-106b, miR-126*) are significantly higher in UA patients compared with patients with NICP, and the addition of the m-HS that combined ECG, age, risk factors and troponin is useful to detect or rule out UA. +circulation_biomarker_prognosis_down 31966775 hsa-mir-26a Thyroid Cancer, Papillary Collectively, down-regulation of serum miR-26a is associated with poor prognosis in PTC and it might be a promising biomarker for this malignancy. +lncRNA target 31966774 hsa-mir-7 Osteosarcoma CONCLUSION The expression of miR-7 was lower in osteosarcoma tissues and cell lines and miR-7 acted as a tumor suppressor. +genetics_knock down_promote 31966771 hsa-mir-138 Carcinoma, Non-Small-Cell Lung The inhibition of NSCLC cell proliferation induced by H19 knockdown required the activity of miR-138, and could be reversed by overexpression of PDK1. +genetics_overexpression_promote 31966756 hsa-mir-202 Myocardial Ischemia The overexpressed miR +transcription factor target 31966751 hsa-mir-132 Benign Paroxysmal Positional Vertigo Considering the important role in angiogenesis, we hypothesized that miR-132 might be involved in RNV. In summary, miR-132 was involved in the development of RNV under H/R conditions, at least partly, through up-regulating Egr1, ERK2, MMP2, VEGFA and VEGFC expression. +other 31966751 hsa-mir-132 Myocardial Ischemia Previous literature represents that miR-132 induces angiogenesis in tumor development and ischemic diseases. +genetics_overexpression_promote 31966750 hsa-mir-154 Liver Cirrhosis The results of Western blot and FQ PCR show that mRNA and protein levels of beta-catenin, Dsh, APC, GSK3, MMP9 decreased significantly, when miR-154 overexpressed in liver fibrosis, while they increased significantly in miR-154 inhibitors group (P < 0.05). +other 31966731 hsa-mir-210 Acute Kidney Injury Correlation analysis demonstrated that miR-210, miR-21, miR-34 were positively correlated with AKI clinical staging (r = 0.56, P < 0.05; r = 0.32, P < 0.05; r = 0.38, P < 0.05, respectively). MiR-210, miR-21, and miR-34 were correlated with AKI staging that could be treated as the biomarker of AKI. +other 31966731 hsa-mir-34 Acute Kidney Injury Correlation analysis demonstrated that miR-210, miR-21, miR-34 were positively correlated with AKI clinical staging (r = 0.56, P < 0.05; r = 0.32, P < 0.05; r = 0.38, P < 0.05, respectively). MiR-210, miR-21, and miR-34 were correlated with AKI staging that could be treated as the biomarker of AKI. +other 31966731 hsa-mir-21 Acute Kidney Injury Correlation analysis demonstrated that miR-210, miR-21, miR-34 were positively correlated with AKI clinical staging (r = 0.56, P < 0.05; r = 0.32, P < 0.05; r = 0.38, P < 0.05, respectively). MiR-210, miR-21, and miR-34 were correlated with AKI staging that could be treated as the biomarker of AKI. +lncRNA target 31966712 hsa-mir-874 Stomach Neoplasms Thus, we concluded that miR-874 inhibits metastasis-relevant traits via targeting SH2B1 in gastric cancer SGC-7901 cells. +lncRNA target 31966704 hsa-mir-421 Liver Neoplasms Therefore, inhibition of intracellular miR-421 expression is an effective strategy for management of terminal hepatocellular carcinoma. +transcription factor target 31966701 hsa-mir-125b Multiple Myeloma We found significantly up-regulation of miR-125b and deregulation of MKK7 in MM. Taken together, our results demonstrated that MKK7 could function as an important tumor suppressor neutralized by miR-125b in MM, suggesting that miR-125b may be a novel potential molecular therapeutic target in the treatment of MM. +lncRNA target 31966687 hsa-mir-148a Breast Neoplasms We therefore suggested that miR-148a is a tumor suppressor, which could be a promising therapeutic target for breast cancer. +other 31966681 hsa-mir-99a Atypical Squamous Cells of the Cervix The expression of miR-99a revealed different trends among the atypical urothelial categories. +circulation_biomarker_diagnosis_up 31966681 hsa-mir-125b Urologic Neoplasms In the step using FFPE tissues, four microRNAs (miR-145, miR-133a, miR-125b, and miR-99a) levels were downregulated and four microRNAs (miR-96, miR-141, miR-200c, and miR-205) were upregulated in the entire spectrum of urothelial neoplasms. +circulation_biomarker_diagnosis_up 31966681 hsa-mir-96 Urologic Neoplasms In the step using FFPE tissues, four microRNAs (miR-145, miR-133a, miR-125b, and miR-99a) levels were downregulated and four microRNAs (miR-96, miR-141, miR-200c, and miR-205) were upregulated in the entire spectrum of urothelial neoplasms. +circulation_biomarker_diagnosis_up 31966681 hsa-mir-133a Urologic Neoplasms In the step using FFPE tissues, four microRNAs (miR-145, miR-133a, miR-125b, and miR-99a) levels were downregulated and four microRNAs (miR-96, miR-141, miR-200c, and miR-205) were upregulated in the entire spectrum of urothelial neoplasms. +circulation_biomarker_diagnosis_up 31966681 hsa-mir-205 Urologic Neoplasms In the step using FFPE tissues, four microRNAs (miR-145, miR-133a, miR-125b, and miR-99a) levels were downregulated and four microRNAs (miR-96, miR-141, miR-200c, and miR-205) were upregulated in the entire spectrum of urothelial neoplasms. +circulation_biomarker_diagnosis_up 31966681 hsa-mir-141 Urologic Neoplasms In the step using FFPE tissues, four microRNAs (miR-145, miR-133a, miR-125b, and miR-99a) levels were downregulated and four microRNAs (miR-96, miR-141, miR-200c, and miR-205) were upregulated in the entire spectrum of urothelial neoplasms. +circulation_biomarker_diagnosis_up 31966681 hsa-mir-200c Urologic Neoplasms In the step using FFPE tissues, four microRNAs (miR-145, miR-133a, miR-125b, and miR-99a) levels were downregulated and four microRNAs (miR-96, miR-141, miR-200c, and miR-205) were upregulated in the entire spectrum of urothelial neoplasms. +circulation_biomarker_diagnosis_up 31966681 hsa-mir-99a Urologic Neoplasms In the step using FFPE tissues, four microRNAs (miR-145, miR-133a, miR-125b, and miR-99a) levels were downregulated and four microRNAs (miR-96, miR-141, miR-200c, and miR-205) were upregulated in the entire spectrum of urothelial neoplasms. +circulation_biomarker_diagnosis_up 31966681 hsa-mir-145 Urologic Neoplasms In the step using FFPE tissues, four microRNAs (miR-145, miR-133a, miR-125b, and miR-99a) levels were downregulated and four microRNAs (miR-96, miR-141, miR-200c, and miR-205) were upregulated in the entire spectrum of urothelial neoplasms. +lncRNA target 31966672 hsa-mir-641 Lung Neoplasms In conclusion, miR-641 inhibited cell proliferation and metastasis but promoted apoptosis in lung cancer cells by targeting PDCD4 and blocking JAK/STAT and PI3K/AKT signal pathways. +other 31966671 hsa-mir-155 Melanoma The luciferases reporter assay showed that miR155 bound to the 3'-UTR of CTHRC1 and regulated the expression of CTHRC1, further influenced the functions of CTHRC1 in human melanoma development. +lncRNA target 31966670 hsa-mir-18a Diabetic Retinopathy Our findings indicated that the down-regulation of UCA1 promoted the expression of miR-18a that led to a reduction in the expression of its target protein, SOX6, thereby contributing to the hypoxia injury following cerebral ischemia. +lncRNA target 31966670 hsa-mir-18a Brain Ischemia Our findings indicated that the down-regulation of UCA1 promoted the expression of miR-18a that led to a reduction in the expression of its target protein, SOX6, thereby contributing to the hypoxia injury following cerebral ischemia. +transcription factor target 31966666 hsa-mir-26b Rhegmatogenous Retinal Detachment, Autosomal Dominant Downregulation of miR-26b can postpone the occurrence and development of RRD through inhibiting Ki-67 and PCNA, regulating cell apoptosis, and restraining RPE cell proliferation and invasion. +circulation_biomarker_prognosis_up 31966656 hsa-mir-675 Colorectal Neoplasms In conclusion, serum miR-675 might serve as a promising biomarker for early detection and prognosis prediction of CRC. +lncRNA target 31966655 hsa-mir-29 Carcinoma, Hepatocellular In conclusion, miR-29 family functions as a novel tumor suppressor in HCC by regulate cell growth and cell cycle through binding to RPS15A 3'UTR. +genetics_GWAS 31966652 hsa-mir-1 Chordoma 5p might be a useful biomarker and a potential therapy for early detection of chordoma as disease-related molecular and genetic changes. +lncRNA target 31966648 hsa-mir-204 Squamous Cell Carcinoma of Head and Neck Thus, our study demonstrated that miR-204 was downregulated in HSCC and upregulation of miR-204 suppressed cell proliferation, which highlighted that miR-204 could have potential therapeutic applications in HSCC. +genetics_overexpression_promote 31966632 hsa-mir-181d Squamous Cell Carcinoma of Head and Neck Importantly, overexpression of K-ras reversed the inhibitory effects of miR-181d mimics on OSCC cells. +genetics_knock down_promote 31966631 hsa-mir-590 Carcinoma, Endometrioid 5p downregulation were rescued by knockdown of PTEN in EEC cells. +lncRNA target 31966622 hsa-mir-140 Nasopharyngeal Carcinoma The current research was designed to delineate the mechanism of miR-140 in regulating NPC via targeting CXCR4. +lncRNA target 31966617 hsa-mir-19b Cardiomyopathies These effects might be mediated through the miR-19b/AKT/mTOR signaling pathway, which provide a new insight into the mechanism by which Irisin may have beneficial effect on myocardial remodeling. +genetics_overexpression_promote 31966610 hsa-mir-941 Breast Neoplasms The overexpression of miR-3941 significantly inhibited the breast cancer cell viability and suppressed cell migration and invasion. +transcription factor target 31966604 hsa-mir-96 Prostatic Neoplasms Thus, these results showed that inhibition of miR-96 may be a target for prostate cancer treatment. +other 31966602 hsa-mir-551b Dementia, Vascular OBJECTIVE: To investigate the effect of the severe acute pancreatitis (SAP)-related miR-551b-5p on intracellular Ca(2+) concentration and c-Kit expression and distribution in rat interstitial cells of Cajal (ICCs) in vitro. +other 31966602 hsa-mir-551b Pancreatitis, Acute Necrotizing OBJECTIVE: To investigate the effect of the severe acute pancreatitis (SAP)-related miR-551b-5p on intracellular Ca(2+) concentration and c-Kit expression and distribution in rat interstitial cells of Cajal (ICCs) in vitro. +lncRNA target 31966599 hsa-mir-211 Stomach Neoplasms These results showed that miR-211 acted as a tumor suppressor in GC and may be a potential target of GC treatment. +circulation_biomarker_prognosis_ns 31966596 hsa-mir-206 Colorectal Neoplasms In summary, serum miR-206 might be a promising biomarker for the diagnosis and prognosis of CRC. +lncRNA target 31966595 hsa-mir-129 Thyroid Cancer, Papillary We confirmed that microRNA-129 may play a major role in PTC through the above pathways, but more experiments are still needed to prove our results. +genetics_overexpression_promote 31966584 hsa-mir-153 Carcinoma, Ovarian Epithelial Overexpression of miR-153 suppressed cell proliferation and migration in ovarian cancer. +genetics_overexpression_promote 31966577 hsa-mir-21 Nasopharyngeal Carcinoma Our results showed that miR-21 overexpression could enhance the chemoresistance of NPC cells to cisplatin, and vice versa. +circulation_biomarker_prognosis_down 31966576 hsa-mir-20 Stomach Neoplasms Furthermore, plasma miR-320 could be used to distinguish gastric cancer patients from healthy controls with an area under the curve (AUC) of 0.861. +genetics_GWAS 31966563 hsa-mir-375 Diabetes Mellitus, Type 2 Epigenetic regulation of microRNA-375 and its role as DNA epigenetic marker of type 2 diabetes mellitus in Chinese Han population. +lncRNA target 31966552 hsa-mir-590 Squamous Cell Carcinoma of Head and Neck 5P targets FasL to inhibit the development of tongue cancer and that miR +other 31966543 hsa-mir-101 Lymphoma, Large B-Cell, Diffuse 3p and c-myc expression in DLBCL, which warrants further confirmation in different cohorts with larger sample sizes. +circulation_biomarker_prognosis_down 31966526 hsa-mir-133b Colorectal Neoplasms Finally, low serum miR-133b level was demonstrated to be an independent risk factor for CRC. +circulation_biomarker_prognosis_ns 31966518 hsa-mir-381 Thyroid Cancer, Papillary Collectively, serum miR-381 might serve as a non-invasive biomarker for the diagnosis and prognosis of PTC. +lncRNA target 31966510 hsa-mir-146a Carcinoma, Non-Small-Cell Lung In conclusion, the study indicates that miR-146a regulates the DDP sensitivity by inhibiting NF-kappaB signaling pathway in NSCLC cells. +lncRNA target 31966509 hsa-mir-153 Vascular Calcification 3p expression attenuates adenine-induced aortic calcification via inhibiting osteogenic trans-differentiation in the thoracic aorta. +lncRNA target 31966509 hsa-mir-153 Renal Insufficiency, Chronic 3p expression attenuates adenine-induced aortic calcification via inhibiting osteogenic trans-differentiation in the thoracic aorta. +genetics_overexpression_promote 31966507 hsa-mir-138 Colorectal Neoplasms Further study showed that the restoration of hTERT expression by an overexpressing plasmid could reverse the effects of miR +lncRNA target 31966504 hsa-mir-21 Carcinoma, Endometrioid Therefore, we concluded that miR-21 could promote cell proliferation and invasion ability, and inhibite cell apoptosis in endometrial carcinoma partially by regulating its target gene PTEN on post-transcriptional level. +lncRNA target 31966501 hsa-mir-124 Nasopharyngeal Carcinoma CONCLUSIONS: MiR-124 enhances cell radiosensitivity by targeting PDCD6, miR-124/PDCD6 axis may facilitate the development of novel targeted therapies for NPC. +circulation_biomarker_diagnosis_down 31966498 hsa-mir-22 Carcinoma, Renal Cell Moreover, the expression of miR-22 could be increased though surgical treatment in serum of RCC patients. +lncRNA target 31966497 hsa-mir-27b Prostatic Neoplasms In the treatment of prostate cancer, miR-27b inhibition had effects to suppress prostate cancer proliferation by regulation PI3K/AKT/P21 signaling pathway. +lncRNA target 31966495 hsa-mir-182 Leukemia CONCLUSION: LncRNA-CAT104 expressed highly in leukemia cells and its silence inhibited cell survival, migration and invasion by downregulating miR-182 expression. miR-182 functioned as an oncogene by upregulating ZEB1 via which miR-182 silence deactivated Wnt/beta-catenin and JNK signal pathways in leukemia cells. +lncRNA target 31966492 hsa-mir-124 Glioma These results indicate that glioma cell growth is suppressed by miR-124 through its negative regulation of Smad2 expression. +circulation_biomarker_diagnosis_ns 31966484 hsa-mir-802 Diabetes Mellitus, Type 2 It has been documented that circulating microRNA (miR)-802 levels are significantly greater in T2DM patients than in healthy subjects. Taken together, miR-802 is required for palmitate-induced damage to beta cells by targeting SIRT6 and represents a potential therapeutic target for T2DM. +transcription factor target 31966478 hsa-mir-222 Squamous Cell Carcinoma of Head and Neck Our findings indicate that miR-222 plays an important role in OSCC, potentially serving as a novel therapeutic target for the treatment of OSCC. +genetics_overexpression_promote 31966476 hsa-mir-26a Urinary Bladder Neoplasms In this study, we found that EZH2 was overexpressed in bladder tumor tissue and miR-26a could downregulate the expression of EZH2 to inhibit proliferation and enhance apoptosis in bladder cancer. +circulation_biomarker_prognosis_up 31966459 hsa-mir-375 Stomach Neoplasms Collectively, serum miR-375 and JAK2 combination may be a potential diagnostic and prognostic predictor of gastric cancer. +circulation_biomarker_diagnosis_up 31966451 hsa-mir-126 Myocardial Infarction, Acute 3p in circulation is a potential novel diagnostic biomarker for AMI. +genetics_overexpression_promote 31966443 hsa-mir-451 Osteosarcoma Finally, overexpression of miR-451 remarkably suppressed the lung metastasis of OS cells. +lncRNA target 31966442 hsa-mir-138 Asthma Typically, OX40 and OX40L in asthma group were determined and the results indicated that the two parameters upregulated in compared with healthy control, while the expressions of them were suppressed by over-expression of miR-138. CONCLUSION: In this study, we revealed that miR-138 might regulate Th2-type immune response by down-regulating the OX40L expression in asthma. +genetics_overexpression_promote 31966441 hsa-mir-143 Pituitary Neoplasms Furthermore, overexpression of K-Ras greatly reversed the suppressive effect of miR-143 on pituitary tumor cells. +lncRNA target 31966437 hsa-mir-1290 Chordoma Conclusively, miRNA-1290 might be a valuable prognostic biomarker and efficient therapeutic target for sacral chordoma. +transcription factor target 31966433 hsa-mir-20b Pneumonia, Mycoplasma The miR-20b/MMP-2 axis may provide novel insights into understanding the molecular pathogenesis of PE and may be a prognostic biomarker and therapeutic target for PE. +circulation_biomarker_diagnosis_ns 31966433 hsa-mir-20b Pre-Eclampsia We found that miR-20b was elevated in placentas and peripheral blood specimens from preeclampsia patients. +transcription factor target 31966430 hsa-mir-145 Mitochondrial Diseases Bioinformatics analysis and dual-luciferase reporter assays indicated that Bnip3, which has a key role in the mitochondrial dysfunction, is a novel target of miR-145. +other 31966416 hsa-mir-320d Squamous Cell Carcinoma of Head and Neck RESULTS: The expression levels of MALAT-1 SRSF1 and CCR7 in OSCC tissues with were differentially higher compared with those of samples without lymph node metastasis as well as para-carcinoma tissues, exclusive of miRNA-320d. +transcription factor target 31966378 hsa-mir-223 Squamous Cell Carcinoma of Head and Neck In addition, ARTN was identified as a direct target of miR-223 and miR-223 suppressed the expression of ARTN in LSCC cells. +genetics_knock down_promote 31966373 hsa-mir-23a Reperfusion Injury In contrast, knockdown of miR-23a by tail injection of antagomir-23a attenuated the ischemic/reperfusion injury. +transcription factor target 31966366 hsa-mir-21 Respiratory Distress Syndrome Here, we hypothesize that miR5p inhibits apoptosis in ATII cells and protects against ARDS. +circulation_biomarker_prognosis_down 31966362 hsa-mir-138 Squamous Cell Carcinoma of Head and Neck Our results demonstrated that serum miR-138 might be a potential biomarker for detection and prognosis prediction of HNSCC. +other 31966358 hsa-mir-29b Pre-Eclampsia Our results demonstrated that upregulation of miR-29b in dMSCs has an important paracrine effect and might be involved in the development of PE. +genetics_knock down_suppress 31966352 hsa-mir-7684 Cognition Disorders Furthermore, miR5p knockdown effectively reduced the levels of Abeta triggered by surgery, and attenuated hippocampal-dependent memory impairment. +transcription factor target 31966082 hsa-mir-519 Breast Neoplasms Furthermore, miR-519 mimics or inhibitors were transfected into breast cancer MCF-7 cells in order to up- or downregulate miR-519 expression. +circulation_biomarker_diagnosis_ns 31966078 hsa-mir-144 Osteosarcoma The relative expression of miR-144 in osteosarcoma and osteosarcoma serum was significantly lower than that in normal bone tissue and normal human serum (P<0.05). +circulation_biomarker_prognosis_up 31966077 hsa-mir-221 Breast Neoplasms miR-221 expression was upregulated and miR-489 expression was downregulated in blood samples of breast cancer patients, which had a certain impact on the patients survival. +lncRNA target 31966076 hsa-mir-15a Lung Neoplasms Inhibition of proliferation, migration and invasion of NSCLC cells can be achieved with targeted regulation of Smad3 by miR-15a. +lncRNA target 31966071 hsa-mir-519 Pancreatic Carcinoma PD-L1 was also identified as a downstream target of miR-519, and rescued the miR-519 mimic-attenuated tumorigenesis of pancreatic cancer cells under hypoxic conditions. +genetics_overexpression_promote 31966062 hsa-mir-101 Liver Neoplasms Therefore, the expression level of miR-101 declines in liver cancer tissues, and the miR-101 overexpression can inhibit the proliferation of liver cancer cells. +other 31966057 hsa-mir-34a Nasopharyngeal Carcinoma The expression levels of miR-34a and Ki67, as well as TNM staging were associated with the prognosis of NPC patients. +lncRNA target 31966056 hsa-mir-125 Stomach Neoplasms PVT1 specifically bound to the 3'UTR of miR-125, whereas the inhibition of PVT1 inhibited the ability of proliferation and invasion of gastric cancer cells. +genetics_overexpression_promote 31966049 hsa-mir-129 Prostatic Neoplasms Cell detection confirmed that the overexpression of miR +circulation_biomarker_diagnosis_ns 31965762 hsa-mir-498 Coronary Artery Disease CONCLUSION: This study demonstrates that the SCD rs41290540 may be associated with a decreased risk of CAD, lower serum TC, and decreased miR-498 binding. +other 31965517 hsa-mir-205 Thyroid Cancer, Papillary 2 were also detected as up-regulated miRNAs in both PTC patients with stage I and stage III. +other 31965517 hsa-mir-514-1 Thyroid Cancer, Papillary 2 were also detected as up-regulated miRNAs in both PTC patients with stage I and stage III. +other 31965517 hsa-mir-514-2 Thyroid Cancer, Papillary 2 were also detected as up-regulated miRNAs in both PTC patients with stage I and stage III. +other 31965517 hsa-mir-509-2 Thyroid Cancer, Papillary 2 were also detected as up-regulated miRNAs in both PTC patients with stage I and stage III. +lncRNA target 31965022 hsa-mir-96 Seminoma 3p, and miR-302a-3p) and genes (EPHA2, JUN, KLF4, PLXDC2, RND3, SPI1, and TIMP3) and NSE-specific dysregulated miRNAs (miR +lncRNA target 31965022 hsa-mir-96 Testicular Germ Cell Tumor 3p, and miR-302a-3p) and genes (EPHA2, JUN, KLF4, PLXDC2, RND3, SPI1, and TIMP3) and NSE-specific dysregulated miRNAs (miR +lncRNA target 31965022 hsa-mir-25 Testicular Germ Cell Tumor 3p, and miR-302a-3p) and genes (EPHA2, JUN, KLF4, PLXDC2, RND3, SPI1, and TIMP3) and NSE-specific dysregulated miRNAs (miR +lncRNA target 31965022 hsa-mir-200c Seminoma 3p, and miR-302a-3p) and genes (EPHA2, JUN, KLF4, PLXDC2, RND3, SPI1, and TIMP3) and NSE-specific dysregulated miRNAs (miR +lncRNA target 31965022 hsa-mir-200c Testicular Germ Cell Tumor 3p, and miR-302a-3p) and genes (EPHA2, JUN, KLF4, PLXDC2, RND3, SPI1, and TIMP3) and NSE-specific dysregulated miRNAs (miR +lncRNA target 31965022 hsa-mir-519d Testicular Germ Cell Tumor 3p, and miR-302a-3p) and genes (EPHA2, JUN, KLF4, PLXDC2, RND3, SPI1, and TIMP3) and NSE-specific dysregulated miRNAs (miR +lncRNA target 31965022 hsa-mir-519d Seminoma 3p, and miR-302a-3p) and genes (EPHA2, JUN, KLF4, PLXDC2, RND3, SPI1, and TIMP3) and NSE-specific dysregulated miRNAs (miR +lncRNA target 31965022 hsa-mir-25 Seminoma 3p, and miR-302a-3p) and genes (EPHA2, JUN, KLF4, PLXDC2, RND3, SPI1, and TIMP3) and NSE-specific dysregulated miRNAs (miR +transcription factor target 31964527 hsa-mir-200b Hypoxia-Ischemia, Brain miR-200b-3p may be a potential therapeutic target of HIBD for further investigation. +genetics_overexpression_promote 31964245 hsa-mir-425 Lung Neoplasms 5p overexpression inhibited A549 lung cancer cell proliferation in vitro and in vivo. +transcription factor target 31963761 hsa-mir-155 Demyelinating Diseases Furthermore, miR5p and miR-20a-5p upregulations enhanced NgR induction through Smad 2 and Smad 4 suppression in demyelination. +transcription factor target 31963761 hsa-mir-20a Demyelinating Diseases Furthermore, miR5p and miR-20a-5p upregulations enhanced NgR induction through Smad 2 and Smad 4 suppression in demyelination. +other 31963351 hsa-mir-20a Breast Neoplasms A panel composed of miR5p, miR-320a, and miR-4433b-5p distinguished BC patients from CT with an area under the curve (AUC) of 0.8387 (93.33% sensitivity, 68.75% specificity). +other 31963351 hsa-mir-4433b Breast Neoplasms A panel composed of miR5p, miR-320a, and miR-4433b-5p distinguished BC patients from CT with an area under the curve (AUC) of 0.8387 (93.33% sensitivity, 68.75% specificity). +other 31963351 hsa-mir-142 Breast Neoplasms A panel composed of miR5p, miR-320a, and miR-4433b-5p distinguished BC patients from CT with an area under the curve (AUC) of 0.8387 (93.33% sensitivity, 68.75% specificity). +genetics_overexpression_promote 31962380 hsa-mir-335 Breast Neoplasms RESULTS: Circ_0007255 and SIX2 were overexpressed, but miR +circRNA target 31962276 hsa-mir-103a Carcinoma, Non-Small-Cell Lung In mechanism, hsa_circ_0062389 directly interacted with miR-103a-3p in NSCLC, and CCNE1 acted as a target of miR-103a-3p. Therefore, our results showed that the hsa_circ_0062389/miR-103a-3p/CCNE1 axis might contribute to the tumorigenesis of NSCLC, which provided a new strategy for cancer treatment. +other 31962131 hsa-mir-942 Carotid Artery Diseases ZEB1-AS1/miR-942/HMGB1 axis might provide a new direction to treatment carotid artery atherosclerosis. +lncRNA target 31962101 hsa-mir-708 Carcinoma, Hepatocellular MicroRNA (miRNA) have emerged as major players in governing fundamental biological processes through multiple mechanisms MiR-708 is known to inhibit the development of hepatocellular carcinoma. +lncRNA target 31962101 hsa-mir-708 Fibrosis Together, our data showed that miR-708 may be a potential therapeutic target in liver fibrosis therapy. +circRNA target 31961997 hsa-mir-326 Breast Neoplasms CONCLUSIONS: Circ-TFF1 is a facilitator in breast cancer relying on TFF1 by absorbing miR-326, providing a novel promising target for BC treatment. +transcription factor target 31961705 hsa-mir-297b Diabetes Mellitus, Type 2 Our findings indicate a suppressive role for miR-297b-5p in stearic acid-induced beta-cell apoptosis, which may reveal a potential target for the treatment of beta-cell dysfunction in the pathogenesis of type 2 diabetes. +genetics_overexpression_suppress 31961204 hsa-mir-137 Brain Injuries The repairing effect and potential mechanism of miR-137 on cerebral ischemic injury in rats was investigated. The results suggested that miR-137 overexpression can effectively improve ischemic injury after focal cerebral ischemia and protect against by inhibiting JAK1/STAT1 pathway. +other 31961004 hsa-mir-449a Thyroid Neoplasms To conclude, the current study indicated that SNHG7 promoted proliferation and migration of TC cells by sponging miR-449a and therefore upregulating ACSL1. +lncRNA target 31960990 hsa-mir-194 Cholangiocarcinoma More important, the elevated expression of miR-194 or ECT2 silencing inhibited the Rho pathway, and further promoted the apoptosis and suppressed the stem cell proliferation, migration, and invasion of CCA in vitro. +lncRNA target 31960988 hsa-mir-186 Adenocarcinoma of Lung In sum, circABCC4 regulates LUAD progression via miR +lncRNA target 31960961 hsa-mir-136 Carcinoma, Non-Small-Cell Lung Consequently, our findings confirmed that circTIMELESS exists in LUSC and acts as a tumor promoter through the miR +lncRNA target 31960827 hsa-mir-410 Glioma CONCLUSIONS Propofol can suppress cell growth and metastasis by regulating the miR +transcription factor target 31960813 hsa-mir-181c Cerebral Hemorrhage In conclusion, miR-181c affects the prognosis of intracerebral hemorrhage by regulating apoptosis, and these effects might be directly mediated and regulated by targeting of the PTEN\PI3K/Akt pathway and Bcl-2/Bax ratio. +lncRNA target 31960764 hsa-mir-7 Osteosarcoma In conclusion, our research uncovered an important role of the cir-ITCH/miR-7/EGFR pathway in the migration and invasion of osteosarcoma cells and suggested that cir-ITCH may be a prognostic marker and a promising therapeutic target for osteosarcoma. +lncRNA target 31960744 hsa-mir-24 Squamous Cell Carcinoma of Head and Neck DISCUSSION: The upregulation of CDKN2B-AS1 was correlated with overall survival, advanced clinical stage, and lymph node metastasis and promoted LSCC cell growth via miR5p/ROCK1 axis. +lncRNA target 31960662 hsa-mir-1290 Leukemia, Myeloid, Acute "We, the Editors and Publisher of Journal of Biological Regulators and Homeostatic Agents, have retracted the following article: ""miR-1290 promotes proliferation and suppresses apoptosis in acute myeloid leukemia by targeting FOXG1/SOCS3""." +other 31960446 hsa-mir-512 Colorectal Neoplasms 5p sponge to upregulate the PTMA expression. +transcription factor target 31960438 hsa-mir-214 Carcinoma, Hepatocellular In summary, our study demonstrates that the ferroptosis-promoting effects of miR-214 in hepatoma cells are attributed at least to its inhibitory effects on ATF4, which may provide a new target for therapy of hepatoma regarding ferroptosis. +genetics_knock down_promote 31960416 hsa-mir-885 Cardiomyopathy, Hypertrophic Moreover, H/R suppressed AKT/mTOR signaling, which was attenuated by miR-885 overexpression in HCMs. +lncRNA target 31959866 hsa-mir-214 Spinal Cord Ischemia Overall, our study identified a novel mechanism of Foxd3/miR-214/Kcnk2 involving SCII, suggesting that either Foxd3 or miR-214 may be a novel target for the treatment of SCII. +other 31959759 hsa-mir-130a Diabetes Mellitus, Type 2 We found that miR-130a and TGFbeta content correlates with sEV in-vitro and in-vivo angiogenic properties, particularly in T2DM patients. +other 31959759 hsa-mir-130a Ciliary Motility Disorders Finally, ROC curve analyses revealed that sEV ineffectiveness could be predicted (Likelihood Ratio+ (LH+) = 3.3 IC 95% from 2.6 to 3.9) by comparing miR-130a and TGFbeta content 'in Series'. +lncRNA target 31959478 hsa-mir-367 Stomach Neoplasms Moreover, we show that HMGA2 was a downstream target of miR +lncRNA target 31959472 hsa-mir-149 Melanoma ADAR1p150 can promote the biosynthesis and function of miRNA-149* in melanoma cells which makes it be considered as both a bio-marker and a therapeutic target for treatment of melanoma. +circulation_biomarker_diagnosis_ns 31959200 hsa-mir-340 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: Taken together, our findings identify two oncogenic regulatory axes in NSCLC centering on LINC01234: one involving miR5p/miR-27b-3p in the cytoplasm and the second involving EZH2, LSD1, and BTG2 in the nucleus. +circulation_biomarker_diagnosis_ns 31959200 hsa-mir-27b Carcinoma, Non-Small-Cell Lung CONCLUSIONS: Taken together, our findings identify two oncogenic regulatory axes in NSCLC centering on LINC01234: one involving miR5p/miR-27b-3p in the cytoplasm and the second involving EZH2, LSD1, and BTG2 in the nucleus. +lncRNA target 31959187 hsa-mir-7 Encephalitis Moreover, miR-7 synergizes with its target gene RORalpha to control the inflammation reaction of neurons, thereby orchestrating the pathology of BTI. +genetics_GWAS 31959117 hsa-mir-155 Stomach Neoplasms This study aims to determine whether genetic variations in MIR155HG could be associated with gastric cancer risk. CONCLUSION: This study confirmed the relationship between SNPs of MIR155HG and the gastric cancer risk among the Chinese Han population. +genetics_overexpression_promote 31959058 hsa-mir-219a-2 Pituitary Neoplasms 3p and MDM2 in the same group and found that it could counteract the effect of overexpressing miR-219a +genetics_overexpression_promote 31958799 hsa-mir-552 Stomach Neoplasms Finally, miR-552 overexpression promoted the proliferation, migration, and invasion of GC cells (p < 0.01). +circulation_biomarker_diagnosis_up 31958764 hsa-mir-95 Colorectal Neoplasms Notably, carcinomatous expressions of miR-95, serum glucocorticoid kinase 1 (SGK1), B-cell lymphoma-2 (Bcl-2), extracellular regulated protein kinase 1 (Erk1) in human CRC were notably elevated when compared to those in non-tumor controls. CONCLUSIONS: Collectively, the current clinical data indicate pathological markers of miR-95, SGK1, Erk1 in human CRC cases, and further experimental findings reveal that anti-CRC pharmacological mechanism using genistein was implicated in suppression of cellular miR-95, SGK1, Erk1 expressions. +other 31958753 hsa-mir-127 Pneumonia, Staphylococcal In the present study, we showed that microRNA (miR)-127 played a key role in controlling bacterial infection and conferred a profound protection against staphylococcal pneumonia. +transcription factor target 31958751 hsa-mir-526b Cardiotoxicity Overall, miR-526b-3p accelerated doxorubicin-induced cardiotoxicity through modulating STAT3/VEGFA, highlighting that targeting miR-526b-3p as a potential method to protect against DOX-induced cardiac dysfunction. +exosome 31958697 hsa-mir-152 Diabetic Foot Taken together, MSC-derived exosomal lncRNA H19 prevented the apoptosis and inflammation of fibroblasts by impairing miR +circulation_biomarker_diagnosis_ns 31958315 hsa-mir-23b Muscular Atrophy In addition, the serum level of miR-23b-3p can be used as a diagnostic marker for muscle atrophy. +transcription factor target 31957920 hsa-mir-204 Dermatitis Herpetiformis Moreover, miR-204 was downregulated in DH chicken compared with SMB chicken, and significantly inhibited the expression of MAP3K13, which is involved in the MAPK pathway. +lncRNA target 31957875 hsa-mir-4319 Carcinoma, Pancreatic Ductal ITGB2-AS1 promoted PDAC progression via inhibition of miR-4319. In conclusion, ITGB2-AS1 promoted PDAC progression via sponging miR-4319 to upregulate RAF1, suggesting the potential therapeutic target ability of ITGB2-AS1 in PDAC. +other 31957854 hsa-mir-410 Fragile X Syndrome 3p) and fragile X mental retardation 1 (Fmr1) mRNA. +circulation_biomarker_diagnosis_ns 31957853 hsa-mir-612 Cardiomegaly PATIENTS AND METHODS: RT-PCR was used to detect the expressions of LUCAT1 and miR-612 in serum samples of CHF patients (n=60) and healthy volunteers. +lncRNA target 31957847 hsa-mir-370 Sepsis 3p suppressed the inflammation and apoptosis while it facilitated the proliferation of LPS-induced RAW 264.7 cells via TSP-1. +lncRNA target 31957840 hsa-mir-5195 Glioma CONCLUSIONS: In this work, we emphasized the suppressor function of miR +genetics_knock down_promote 31957837 hsa-mir-3666 Lung Neoplasms The inhibitory proliferation and invasion, and acceleratory apoptosis of lung cancer cells, caused by miR-3666 enrichment, were overturned by E2F2 overexpression. +lncRNA target 31957836 hsa-mir-197 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: LncRNA SNHG20 promotes the proliferation and inhibits the apoptosis of NSCLC cells by targeting miR-197 through the Wnt/beta-catenin signaling pathway. +lncRNA target 31957833 hsa-mir-124 Tongue Neoplasms 3p targeted TRIM14 and the downregulation of TRIM14 reduced the DDP resistance of tongue cancer cells. +genetics_overexpression_promote 31957831 hsa-mir-326 Nasopharyngeal Carcinoma CONCLUSIONS: Overexpression of microRNA-326 in NPC cells could remarkably inhibit the proliferative capacity and invasiveness of NPC cells. +lncRNA target 31957829 hsa-mir-214 Esophageal Squamous Cell Carcinoma 5p/RAB14 axis and it might serve as a therapeutic target for ESCC treatment. +lncRNA target 31957828 hsa-mir-384 Esophageal Squamous Cell Carcinoma CONCLUSIONS: Abundance of circ_0006168 contributes to cell proliferation, migration, invasion, and glycolysis in EC by competitively sponging miR-384 to facilitate RBBP7 expression, representing prospective targets for EC therapy. +genetics_overexpression_suppress 31957824 hsa-mir-497 Carcinoma, Pancreatic Ductal In in vitro assay, we demonstrated that miR-497 overexpression inhibited cell proliferation, migration, and invasion of PDAC. +transcription factor target 31957822 hsa-mir-140 Wilms Tumor 5p and miR-92a-3p attenuated the aggressive progression of WT via targeting FRS2. +transcription factor target 31957822 hsa-mir-92a Wilms Tumor 5p and miR-92a-3p attenuated the aggressive progression of WT via targeting FRS2. +genetics_overexpression_suppress 31957821 hsa-mir-589 Urinary Bladder Neoplasms In addition, overexpression of microRNA +epigenetics 31957820 hsa-mir-361 Prostatic Neoplasms The BALCAT1 promoter was methylated in prostate cancer tissue and found to interact with miR-361 via luciferase assays. +genetics_knock down_promote 31957819 hsa-mir-96 Ovarian Neoplasms CONCLUSIONS: The knockdown of miRNA-96 attenuated the proliferative and migratory abilities in OC cells by targeting FOXO3a. +genetics_overexpression_promote 31957818 hsa-mir-149 Ovarian Neoplasms MiR-149 overexpression significantly suppressed the OC cell proliferation, invasion, and migration as determined by functional assays, including MTT (3-(4,5-dimethylthiazol +genetics_overexpression_promote 31957815 hsa-mir-188 Osteosarcoma In addition, overexpression of CCNT2 could partially reverse the inhibitory effect of miRNA +lncRNA target 31957813 hsa-mir-7a Spinal Cord Injuries CONCLUSIONS: The up-regulation of miR-7a alleviated the injury-induced oxidative stress and inhibited apoptosis by down-regulating NF-kappaB pathway in SCI rats. +circulation_biomarker_diagnosis_ns 31957812 hsa-mir-1286 Osteoporosis RESULTS: The expression of microRNA-1286 in the serum of patients with osteoporosis was significantly higher than that of the normal population. +genetics_knock down_promote 31957742 hsa-mir-199 Osteoarthritis, Knee CONCLUSIONS Expression levels of miR-140 and miR-199 in synovia might act as an early diagnostic marker for KOA. +lncRNA target 31957704 hsa-mir-506 Diabetic Nephropathies NEAT1 was upregulated while miR-506 was downregulated in the progression of NAFLD. lncRNA NEAT1 could regulate fibrosis, inflammatory response, and lipid metabolism via the miR-506/GLI3 axis as a ceRNA, which is a novel mechanistic role in the regulation of NAFLD. +lncRNA target 31957704 hsa-mir-506 Non-alcoholic Fatty Liver Disease NEAT1 was upregulated while miR-506 was downregulated in the progression of NAFLD. lncRNA NEAT1 could regulate fibrosis, inflammatory response, and lipid metabolism via the miR-506/GLI3 axis as a ceRNA, which is a novel mechanistic role in the regulation of NAFLD. +transcription factor target 31957613 hsa-mir-340 Alzheimer Disease CONCLUSION: MiR-340 was downregulated in AD and reduced the accumulation of amyloid-beta through targeting BACE1, suggesting a potential therapeutic target for AD. +genetics_overexpression_promote 31957545 hsa-mir-146a Esophageal Squamous Cell Carcinoma MiR-146a overexpression promoted immature DC to induce regulatory T cells (Treg) differentiation. +circRNA target 31957232 hsa-mir-28 Breast Neoplasms The target gene of miR +transcription factor target 31957170 hsa-mir-129-1 Cardiotoxicity The miR1-3p/Ca(2+) signalling pathway could serve as a target for the development of new cardioprotective agents to control THP-induced cardiotoxicity. +other 31957170 hsa-mir-129-1 Cardiovascular Diseases We previously showed that MiR1-3p, a potential biomarker of cardiovascular disease, was down-regulated in a rat model of THP-induced cardiac injury. +other 31957170 hsa-mir-129-1 Heart Diseases We previously showed that MiR1-3p, a potential biomarker of cardiovascular disease, was down-regulated in a rat model of THP-induced cardiac injury. +other 31957170 hsa-mir-129-1 Heart Injuries We previously showed that MiR1-3p, a potential biomarker of cardiovascular disease, was down-regulated in a rat model of THP-induced cardiac injury. +other 31957033 hsa-mir-4731 Glioblastoma The effects of miR-4731 on cell proliferation and cell cycle of glioma cells were analyzed by wound test and flow-cytometry assay. Our findings suggest that AD-MSCs expressing miR-4731 have favorable antitumor characteristics and should be further explored in future glioma therapy. +genetics_knock down_promote 31957029 hsa-mir-628 Carcinoma, Pancreatic Ductal Gain- and loss-of-function and the putative targets of miR +other 31956957 hsa-mir-195 Hypertrophy Delivering the miR5p Tough Decoy to the cartilage cells can prevent the occurrence of hypertrophy in chondrocytes and could be considered as a candidate for the treatment of other diseases such as osteoarthritis. +exosome 31956955 hsa-mir-30 Breast Neoplasms CAF-secreted exosomal lncRNA SNHG3 served as a molecular sponge for miR +circulation_biomarker_diagnosis_ns 31956442 hsa-mir-615 Liver Cirrhosis This study aimed at investigating plasma miR-484, miR-524, miR +circulation_biomarker_diagnosis_up 31956442 hsa-mir-484 Carcinoma, Hepatocellular Plasma miR-484 levels exhibited significant downregulation in advanced fibrosis as compared to mild fibrosis and HCC. +circulation_biomarker_diagnosis_up 31956442 hsa-mir-484 Liver Cirrhosis Plasma miR-484 levels exhibited significant downregulation in advanced fibrosis as compared to mild fibrosis and HCC. +circulation_biomarker_diagnosis_ns 31956442 hsa-mir-524 Liver Cirrhosis This study aimed at investigating plasma miR-484, miR-524, miR +circulation_biomarker_diagnosis_ns 31956442 hsa-mir-524 Carcinoma, Hepatocellular This study aimed at investigating plasma miR-484, miR-524, miR +circulation_biomarker_diagnosis_ns 31956442 hsa-mir-615 Carcinoma, Hepatocellular This study aimed at investigating plasma miR-484, miR-524, miR +transcription factor target 31956374 hsa-mir-149 Carcinoma, Hepatocellular 5p to promote HCC progression and targeting the M2 macrophages/miR149-5P/MMP9 signaling may help in the development of the novel therapies to better suppress the HCC progression. +circRNA target 31956297 hsa-mir-144 Pneumonia, Mycoplasma RESULTS: Our data indicated that circZDHHC20 was up-regulated and miR-144 was down-regulated in PE placenta. CONCLUSION: Our study suggested that a high level of circZDHHC20 inhibited the proliferation, migration, and invasion in trophoblast cells at least partially through sponging miR-144 and up-regulating GRHL2, providing a novel mechanism of PE pathogenesis. +lncRNA target 31956270 hsa-mir-4500 Carcinoma, Non-Small-Cell Lung Therefore, the USP21/YY1/SNHG16/miR-4500 axis may be a potential therapeutic target in NSCLC treatment. +circulation_biomarker_diagnosis_up 31956131 hsa-mir-202 Coronary Disease 3p in peripheral blood cells and found that miR +circulation_biomarker_diagnosis_up 31956102 hsa-mir-27a Cholangiocarcinoma In addition, hsa-miR-27a-3p was found to be significantly upregulated in the cancer tissues and peripheral plasma of ICC patients (p<0.05). +transcription factor target 31955591 hsa-mir-1180 Cardiomyopathies The expression of miR-1180 is down-regulated in cells subjected to hypoxia-reoxygenation, and use of an miR-1180 mimic significantly reduced myocardial injury and cell apoptosis. These findings suggest that miR-1180 maybe a novel therapeutic target for use in getting cardiomyocytes to re-enter the cell cycle as well as for cardiac repair following myocardial injury. +lncRNA target 31955177 hsa-mir-639 Carcinoma, Hepatocellular MATERIAL AND METHODS Expression levels of miR-639 were compared in tumor tissue and adjacent normal liver tissue from 50 patients with HCC, and Kaplan-Meier curves identified the association with overall survival (OS). CONCLUSIONS miR-639 was down-regulated in HCC tumor tissue, and inhibited proliferation and migration of HCC cells by the down-regulation of KAT7/Wnt/ss-catenin signaling and was associated with reduced OS. +transcription factor target 31955160 hsa-mir-204 Asthma 5p inhibits TGF-beta1-in-duced proliferation and ECM production of airway smooth muscle cells by regulating Six1, identifying a potential therapeutic target for preventing airway remodeling in asthma. +transcription factor target 31955010 hsa-mir-1205 Colorectal Neoplasms We also found that MYO6 was a direct target of miR-1205, which functioned as an oncogene in CRC. +exosome 31955007 hsa-mir-181d Breast Neoplasms Herein, we identify CAF-derived exosomes that can transfer miR-181d-5p to enhance the aggressiveness of breast cancer. In conclusion, exosomal miR-181d-5p plays a key role in CAF-mediated effects on tumor environment in breast cancer, likely via CDX2 and HOXA5. +genetics_overexpression_promote 31954745 hsa-mir-106b Lung Neoplasms More importantly, PTEN overexpression reversed the effect of exosomal miR-106b on lung cancer cell migration and invasion. +lncRNA target 31954705 hsa-mir-212 Aortic Aneurysm, Abdominal 5p/BASP1 pathway, suggesting LINC00473 as a promising target for AAA therapy. +other 31954666 hsa-mir-184 Corneal Neovascularization The up-regulation of cZNF609 and down-regulation of miR-184 were observed during corneal neovascularization. Intervention of cZNF609 and miR-184 may serve as a potential strategy for pathological corneal neovascularization treatment. +transcription factor target 31954517 hsa-mir-25 Epilepsy Those data indicated that miR3p had anti-epileptic, anti-oxidant and anti-apoptosis effects on the primarily cultured neurons through targeting OXSR1, which provided a novel target for the treatment of epilepsy. +circulation_biomarker_diagnosis_ns 31954402 hsa-mir-33a Dengue METHODS: The relative expression of microRNA hsa-let-7e (let-7e), hsa-miR-30b-5p (miR-30b), hsa-miR-30e-3p (miR-30e), hsa-miR-33a (miR-33a), and hsa-miR5p (miR-150) and several putative target genes in peripheral blood cells (PBC) collected from 20 DF and 20 SD positive patients within 4 days from fever onset was evaluated by quantitative reverse transcription PCR (qRT-PCR). +circulation_biomarker_diagnosis_ns 31954402 hsa-let-7e Dengue METHODS: The relative expression of microRNA hsa-let-7e (let-7e), hsa-miR-30b-5p (miR-30b), hsa-miR-30e-3p (miR-30e), hsa-miR-33a (miR-33a), and hsa-miR5p (miR-150) and several putative target genes in peripheral blood cells (PBC) collected from 20 DF and 20 SD positive patients within 4 days from fever onset was evaluated by quantitative reverse transcription PCR (qRT-PCR). +circulation_biomarker_diagnosis_up 31954402 hsa-mir-150 Dengue 5p (miR-150) and several putative target genes in peripheral blood cells (PBC) collected from 20 DF and 20 SD positive patients within 4 days from fever onset was evaluated by quantitative reverse transcription PCR (qRT-PCR). +genetics_overexpression_suppress 31954330 hsa-mir-129 Glioma Additionally, wound healing assays indicated that miR-129 overexpression inhibits cell growth of glioblastoma cells. These findings introduced novel targets for miR-129 in glioblastoma cells. +lncRNA target 31954329 hsa-mir-143 Prostatic Neoplasms "In summary, our study demonstrated that UCA1 exerts oncogenes activity in PCa, acting mechanistically by upregulating MYO6 expression through ""sponging"" miR-143." +genetics_knock down_promote 31954160 hsa-mir-429 Melanoma SIGNIFICANCE: Knockdown of circ_0084043 suppressed the malignant development of melanoma presumably through modulating miR429/TRIB2 axis and inactivating Wnt/beta-catenin signaling pathway. +circulation_biomarker_diagnosis_ns 31954077 hsa-let-7b psoriasis 1 Significantly lower levels of plasma EV let-7b-5p and miR-30e-5p in PsA vs. +circulation_biomarker_diagnosis_ns 31954077 hsa-let-7b Arthritis, Psoriatic Significantly lower levels of plasma EV let-7b-5p and miR-30e-5p in PsA vs. +genetics_knock down_promote 31953899 hsa-mir-520a Carcinoma, Non-Small-Cell Lung Additionally, rescue assay exhibited the anticancer activity mediated by SNHG16 knockdown on NSCLC could be reversed by miR-520a-3p inhibition or EphA2 overexpression. +other 31953889 hsa-mir-27b Schistosomiasis It reveals that manipulation of miR-27b or KSRP might be a useful strategy not only for treating Schistosome-induced hepatic fibrosis but also for curing hepatic fibrosis in general. +other 31953889 hsa-mir-27b Liver Cirrhosis It reveals that manipulation of miR-27b or KSRP might be a useful strategy not only for treating Schistosome-induced hepatic fibrosis but also for curing hepatic fibrosis in general. +genetics_overexpression_promote 31953872 hsa-mir-190b Urinary Bladder Neoplasms Overexpression of miR-190b enhanced the proliferation, growth, migration and invasion capabilities, and angiogenesis of bladder cancer cells, whereas downregulation of miR-190b reversed these effects. +other 31953701 hsa-mir-125a Inflammation Based on the important role of Fyn and microRNA-125a-3p (miR-125a-3p) in inflammation, and combined with the bioinformatics studies, we performed in this study and chose miR-125a-3p as the focus of our research. During the progression of inflammation, we found that the expression of miR-125a-3p was decreased while the expression of Fyn was up-regulated. +transcription factor target 31953701 hsa-mir-125a Dental Caries These findings suggested that miR-125a-3p plays an important role in odontoblastic differentiation of DPSCs by targeting Fyn, implying its therapeutic potential in dental caries. +genetics_knock down_promote 31953613 hsa-mir-1271 Multiple Myeloma 5p and SOX13 overexpression weakened the effects of miR +lncRNA target 31953163 hsa-mir-660 Thyroid Neoplasms Collectively, our data clearly indicate that ASMTL-AS1 functions as a novel tumor suppressor in PTC through regulation of miR3p/miR-660/FOXO1 pathway. +lncRNA target 31953163 hsa-mir-93 Thyroid Neoplasms Collectively, our data clearly indicate that ASMTL-AS1 functions as a novel tumor suppressor in PTC through regulation of miR3p/miR-660/FOXO1 pathway. +genetics_knock down_promote 31953162 hsa-mir-346 Colorectal Neoplasms 5p knockdown on CRC tumorigenesis in vivo was investigated. +other 31953159 hsa-mir-1 Pre-Eclampsia 5p-ETBR axis regulates angiogenesis during the pathological process of PE. +genetics_overexpression_promote 31953039 hsa-mir-431 Pancreatic Neuroendocrine Tumor Overexpression of DAB2IP's rat homolog, but not its mutant defective in Ras GTPase activating protein activity, reverses miR-431's effect on promoting invasion, Erk phosphorylation, and epithelial-mesenchymal transition of PNETs. +other 31952976 hsa-mir-223 Inflammation New Zealand White rabbits (20 females) were used to detect the effect of miR-223 on the rabbit glaucoma model induced by injection of carbomer. CONCLUSIONS: In summary, miR-223 plays a vital role in RGCs by regulating HSP-70 expression, and the new therapeutic strategy might potentially contribute to benefit glaucoma treatment. +other 31952855 hsa-mir-29a Atrial Fibrillation non-PoAF patients with a reduction in miR-29 levels and correlated with atrial fibrosis extent. Combining age as the only significant clinical predictor with PIIINP and miR-29a provided a model that identified PoAF patients with higher predictive accuracy. +other 31952855 hsa-mir-29 Atrial Fibrillation non-PoAF patients with a reduction in miR-29 levels and correlated with atrial fibrosis extent. Combining age as the only significant clinical predictor with PIIINP and miR-29a provided a model that identified PoAF patients with higher predictive accuracy. +genetics_knock down_promote 31952546 hsa-mir-202 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Both gain- and loss-of-function experiments were used to investigate the roles of USP15, miR +lncRNA target 31952480 hsa-mir-32 Vascular Calcification CONCLUSIONS: The production of TNFalpha in microglia could be affected by miR32-5p targeting PIKfyve, and these results will be beneficial to reveal the mechanism of brain arterial calcification. +other 31952315 hsa-mir-166a Infertility, Female thaliana transformed with 35S-pre-pg-miR166a-3p verified the role of pg-miR166a-3p in ovule development, which indicated pg-miR166a-3p's potential role in pomegranate female sterility. +genetics_GWAS 31951899 hsa-mir-21 Chemical and Drug Induced Liver Injury In conclusion, from the perspective of epigenetics, the present study revealed that ROS-mediated miR5p regulated the proliferation and apoptosis of Cr(VI)-exposed L02 hepatocytes via targeting PDCD4, which provided the new targets for molecular intervention and treatment of liver damage in Cr(VI)-exposed population. +genetics_overexpression_promote 31951879 hsa-mir-299 Lymphohistiocytosis, Hemophagocytic Overexpression of miR +lncRNA target 31951855 hsa-mir-1179 Thyroid Cancer, Papillary In summary, our study demonstrated that circFOXM1 modulates cancer progression through the miR-1179/HMGB1 pathway in PTC. +lncRNA target 31951852 hsa-mir-143 Carcinoma, Non-Small-Cell Lung Furthermore, bioinformatics online programs and luciferase reporter assay were used to validate the association of UCA1 and miR-143 in NSCLC cells. We then dissected the effect of miR-143 on gefitinib resistance in NSCLC and proved the suppressive role of miR-143. +lncRNA target 31951832 hsa-mir-28 Colorectal Neoplasms Taken together, our data indicated an essential role of the circCAMSAP1/miR5p/E2F1 axis in the progression of CRC, which implied that circCAMSAP1 could serve as a diagnostic and prognostic biomarker as well as a potential therapeutic target for CRC. +other 31951177 hsa-mir-143 Osteoporosis OBJECTIVE: To explore the effect of miRNA-143 on osteoclast formation and provide new ideas for the treatment of osteoporosis. +circulation_biomarker_diagnosis_ns 31951022 hsa-mir-93 Femur Head Necrosis Finally, the results of quantitative real-time polymerase chain reaction confirmed the significantly higher expression of miR5p and miR-320a in the serum of patients with ONFH. +circulation_biomarker_diagnosis_ns 31951022 hsa-mir-20a Femur Head Necrosis Finally, the results of quantitative real-time polymerase chain reaction confirmed the significantly higher expression of miR5p and miR-320a in the serum of patients with ONFH. +lncRNA target 31951013 hsa-mir-124 Alzheimer Disease Thus, targeting the miR-124/PTPN1 signaling pathway is a promising therapeutic strategy for AD. +lncRNA target 31950540 hsa-mir-125b Cardiomyopathies In this study, we found that circ_LAS1L was down-regulated in acute myocardial infarction (AMI) patients and cardiac fibroblasts (CFs), and could bind directly to miR-125b, thereby promoting the expression of downstream target gene secreted frizzled-related protein 5 (SFRP5), ultimately inhibiting the activation, proliferation and migration of CF, and promoting apoptosis. This suggests that circ_LAS1L/miR-125b/SFRP5 pathway can regulate the biological function of CF and may play an important role in the process of myocardial fibrosis, thus providing an important theoretical basis for the regulation of myocardial fibrosis after myocardial infarction. +lncRNA target 31950540 hsa-mir-125b Fatigue Syndrome, Chronic In this study, we found that circ_LAS1L was down-regulated in acute myocardial infarction (AMI) patients and cardiac fibroblasts (CFs), and could bind directly to miR-125b, thereby promoting the expression of downstream target gene secreted frizzled-related protein 5 (SFRP5), ultimately inhibiting the activation, proliferation and migration of CF, and promoting apoptosis. +lncRNA target 31950540 hsa-mir-125b Myocardial Infarction In this study, we found that circ_LAS1L was down-regulated in acute myocardial infarction (AMI) patients and cardiac fibroblasts (CFs), and could bind directly to miR-125b, thereby promoting the expression of downstream target gene secreted frizzled-related protein 5 (SFRP5), ultimately inhibiting the activation, proliferation and migration of CF, and promoting apoptosis. +genetics_overexpression_promote 31950540 hsa-mir-125b Cystic Fibrosis When cotransfected with circ_LAS1L overexpression vector and miR-125b mimics, the above gene expression and CF biological behaviours did not change significantly. +genetics_overexpression_promote 31950510 hsa-mir-21 Carcinoma, Squamous Cell, Cutaneous Overexpression of NKILA repressed the proliferation and promoted the apoptosis of CSCC cells, while miRNA-21 showed opposite functions. +other 31950451 hsa-mir-124 Reperfusion Injury, Cerebral Ischemia In conclusion, miR5p/NOX2 axis modulates NOX-mediated ROS production, the inflammatory microenvironment, subsequently the apoptosis of neurons, finally affecting the cerebral I/R injury. +lncRNA target 31950433 hsa-mir-4458 Osteosarcoma Moreover, MAP3K3 was certified as a downstream target of miR-4458 in OS. +circulation_biomarker_diagnosis_ns 31950345 hsa-mir-154 Diabetes Mellitus, Type 2 These findings indicated that elevated serum miR +other 31950277 hsa-mir-199b Carcinoma, Hepatocellular A method is described for the simultaneous determination of hepatocellular carcinoma-associated microRNA-122 and microRNA-199a/b-3p. +other 31950277 hsa-mir-122 Carcinoma, Hepatocellular A method is described for the simultaneous determination of hepatocellular carcinoma-associated microRNA-122 and microRNA-199a/b-3p. +other 31950277 hsa-mir-199a Carcinoma, Hepatocellular A method is described for the simultaneous determination of hepatocellular carcinoma-associated microRNA-122 and microRNA-199a/b-3p. +epigenetics 31950130 hsa-mir-223 Coronary Artery Disease Interestingly, mir-223 hypomethylation and altered expression were associated with cerebral infarction and stroke. +lncRNA target 31949884 hsa-mir-181b Inflammation Importantly, positive modulation of miR181b and inhibition of MALAT1 and TOX significantly attenuated oxLDL-induced endothelial inflammation and oxidative stress. +other 31949884 hsa-mir-181b Angelman Syndrome AS tissues were collected to determine the level of MALAT1 expression in AS patients, together with determination of miR-181b expression. +lncRNA target 31949884 hsa-mir-181b Dehydration In summary, MALAT1 suppression protects the endothelium from oxLDL-induced inflammation and oxidative stress in endothelial cells by upregulation of miR-181b and downregulation of TOX. +lncRNA target 31949846 hsa-mir-142 Glioma 3p inhibits proliferation and induces apoptosis by targeting HMGB1 via the Wnt/beta-catenin signaling pathway in glioma cells, providing a deep exploration into the roles and molecular basis of miR +lncRNA target 31949837 hsa-mir-505 Glioma Taken together, our results suggest that miR-505 acts as a tumor suppressor in glioma via direct negative regulation of IGF1R, which may provide a novel therapeutic strategy. +other 31949835 hsa-let-7 Dental Pulp Diseases Lin28 was involved in the reparative process of the dentin-dental pulp complex and HDPCs exposed to LPS, and Lin28/let-7 may be the underlying mechanism. +lncRNA target 31949834 hsa-mir-223 Nasopharyngeal Carcinoma Taken together, these results indicate that miR-223 functions as a tumor suppressor miRNA in NPC and that its suppressive effects are primarily mediated by repressing SSRP1 expression and inhibiting EMT. +circulation_biomarker_prognosis_ns 31949830 hsa-mir-1 Squamous Cell Carcinoma of Head and Neck Moreover, serum miR-31 performed well to distinguish HNSCC subjects from controls. +other 31949829 hsa-mir-145 Retinoblastoma PURPOSE: To investigate the effect of miR-145 on the proliferation and apoptosis of human retinoblastoma Y79 cells and to explore the underlying mechanism. miR-145 restrained the proliferation of human retinoblastoma Y79 cells by down-regulating the expression of IGF-1R. +lncRNA target 31949828 hsa-mir-134 Melanoma Our findings suggest that miR-134 could inhibit the growth and metastasis of melanoma by negatively regulating CTHRC1. +circulation_biomarker_prognosis_ns 31949814 hsa-mir-106b Colorectal Neoplasms Collectively, our findings suggest serum miR-106b might potentially serve as a promising biomarker in the diagnosis and prognosis of CRC. +genetics_overexpression_promote 31949812 hsa-mir-153 Parkinson Disease In this study, we aimed to explore the influences of miR-153 and Nrf2 in oxidative stress during the development of PD. Therefore, these findings indicated that overexpression of miR-153 could promote oxidative stress in PD by targeting the Nrf2/HO-1 signaling pathway, possibly providing a new way to treat PD. +lncRNA target 31949811 hsa-mir-21 Carcinoma, Hepatocellular AIM: To investigate the putative role of interleukin (IL)-6/Janus Kinase (JAK) 2/Signal transducers and activators of transcription (STAT) 3 signaling pathway in hepatocellular carcinoma (HCC) short term recurrence (STR), and whether the pathway promotes HCC progression through microRNA +other 31949792 hsa-mir-149 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Background: Herein, we aimed to investigate the roles of TAL1 and miR-149* in T cell acute lymphoblastic leukemia (T-ALL). Conclusion: Thus, these data indicate that TAL1 directly regulates miR-149* expression and TAL1/miR-149* link is implicated in the pathogenesis of T-ALL. +other 31949785 hsa-mir-181a Prostatic Neoplasms Our results suggest miR-181a-5p may be adiagnostic and therapeutic biomarker for prostate cancer. +lncRNA target 31949784 hsa-mir-155 Carcinoma, Hepatocellular CONCLUSION: This study demonstrated that IMD can promote the proliferation of human hepatic carcinoma cell line SMMC7721 cells through upregulation of miR-155. +other 31949783 hsa-mir-19b Colorectal Neoplasms In summary, the study provides the first convincing statistical and experimental evidence that the up-regulation of miR-19b is associated with metastasis and predicts unfavorable prognosis in patients with CRC, suggesting that miR-19b may serve as a novel and promising prognostic biomarker in CRC. +lncRNA target 31949782 hsa-mir-493 Uterine Cervical Neoplasms Namely, UCA1 could reverse the inhibitory effect of miR +transcription factor target 31949780 hsa-mir-22 Angelman Syndrome Interestingly, Cyr61, a novel pro-inflammatory factor involved in the pathogenesis of atherosclerosis (AS), was identified as a direct target of miR-22. The results clearly show that simvastatin inhibits the inflammation response in LPS-stimulated RAW264.7 macrophages through the miR-22/Cyr61 axis and suggests that targeting the miR-22/Cyr61 axis may be a promising molecular target for AS therapy. +transcription factor target 31949777 hsa-mir-195 Urinary Bladder Neoplasms Results showed that miR-195 was down expressed in bladder cancer tissues and cell lines, which inhibited EMT, cell migration, and invasion. +circulation_biomarker_diagnosis_down 31949768 hsa-mir-340 Stomach Neoplasms Abnormal expression of microRNA-340 has been frequently reported in many malignant neoplasms, while the molecular mechanism of miR-340 has not been explored in gastric cancer. In conclusion, miR-340 induced cell apoptosis and inhibited invasion by down-regulation of NF-kappaB1, which might be a potential target in treatment and prevention of gastric cancer. +genetics_knock down_promote 31949767 hsa-mir-204 Pancreatic Carcinoma Rescue experiments further showed that ZEB1 overexpression abrogated the effects of miR-204 in PC cells. +transcription factor target 31949724 hsa-mir-30 Sialorrhea Collectively, these data reveal that miR-330 inhibits ILinduced MUC5AC secretion in human bronchial epithelial cells by targeting Munc18b, encouraging us to further explore the potential of manipulating miR-330 in treatment of airway diseases with mucus hypersecretion. +circulation_biomarker_diagnosis_down 31949724 hsa-mir-30 Asthma Recently, miR-330 has been reported to be downregulated in the blood of asthmatic patients, acting as a biomarker for asthma. The role of miR-330 in asthma, however, is unclear. +transcription factor target 31949724 hsa-mir-30 Bronchial Diseases Collectively, these data reveal that miR-330 inhibits ILinduced MUC5AC secretion in human bronchial epithelial cells by targeting Munc18b, encouraging us to further explore the potential of manipulating miR-330 in treatment of airway diseases with mucus hypersecretion. +genetics_knock down_promote 31949723 hsa-mir-126 Leukemia Knockdown of miR-126 in KG-1a-LSCs and MOLM13-LSCs inhibited cell proliferation, and promoted apoptosis. +genetics_overexpression_promote 31949718 hsa-mir-206 Glioma To explore the crucial role of miR-206 in gliomas, we constructed miR-206 stably overexpressed LN229 glioma cell lines and found that the proliferation is significantly inhibited. +circulation_biomarker_diagnosis_up 31949715 hsa-mir-26b Alzheimer Disease Blank mimic, miR-26b mimic, blank inhibitor and miR-26b inhibitor plasmids were transferred into PC12 cellular AD models as NC1-mimic, miR-26b mimic, NC2-inhibitor and miR-26b inhibitor groups respectively. +other 31949697 hsa-mir-424 Myocardial Reperfusion Injury In the present study, we aimed to investigate whether miR-424 modulated pyroptosis in response to myocardial IRI and determine its underlying regulatory mechanism. Taken together, our findings provided a new signaling pathway of miR-424/CRISPLD2 in cardiac pyroptosis under IRI conditions. +lncRNA target 31949678 hsa-mir-1471 Glioma Overall, these results reveal the tumor suppressive role of miR-1471 in glioma, highlighting the potential to consider miR-1471/MTDH axis as a therapeutic target for the treatment of glioma in the near future. +genetics_knock down_promote 31949677 hsa-mir-129 Ovarian Neoplasms, High-Grade Serous 3p overexpression distinctively inhibited the proliferation, migration, and invasion of ovarian cancer cells. +genetics_knock down_promote 31949677 hsa-mir-129-1 Ovarian Neoplasms, High-Grade Serous 3p overexpression distinctively inhibited the proliferation, migration, and invasion of ovarian cancer cells. +circulation_biomarker_diagnosis_up 31949675 hsa-mir-9 Ischemic Stroke RESULTS: We found that the serum level of miR-9 in 65 AIS patients was significantly higher than that in control group (no-AIS), and was positively correlated with NIHSS score (r=0.627, P<0.001), infarct volume ((r=0.576, P<0.001), serum IL-8 (r=0.376, P=0.002), TNF-alpha (r=0.418, P<0.001), IL-6 (r=0.545, P<0.001), and IL-1beta (r=0.592, P<0.001). +lncRNA target 31949668 hsa-mir-21 Stomach Neoplasms CONCLUSION: Curcumin had anti-tumor effects to gastric cancer via ion of miRNA-21 by regulation of the PTEN/PI3K/AKT pathway. +transcription factor target 31949667 hsa-mir-126 Ovarian Neoplasms CONCLUSION: We found LNC01133 was an oncogene in OC, which is targeted by miR-126. +other 31949664 hsa-let-7b Stomach Neoplasms LncRNA CERNA2 (competing endogenous lncRNA 2 for microRNA let-7b) was previously found to be upregulated and play an oncogenic role in hepatocellular carcinoma, osteosarcoma and breast cancer. +genetics_knock down_suppress 31949662 hsa-mir-23b Spinal Cord Injuries Then, the effects of miR-23b on the apoptosis were investigated through both gain- and loss-of-function studies in this cellular model of SCI. +genetics_overexpression_promote 31949662 hsa-mir-23b Vaginosis, Bacterial Furthermore, overexpression of miR-23b inhibited the BV-2 apoptosis and NF-kappaB activation, while miR-23b inhibition enhanced the apoptosis and NF-kappaB activation induced by H(2)O(2). +other 31949659 hsa-mir-142 Inflammatory Bowel Diseases 5p improved the intestinal inflammation of active-UC patients by downregulating SOCS1 expression and increasing the cytokines IL-6 and IL-8 secretion. +genetics_overexpression_suppress 31949657 hsa-mir-20a Endometrial Neoplasms Functional analysis revealed that miR-20a-5p overexpression inhibited EMT and invasion of EC cells. +genetics_knock down_promote 31949656 hsa-mir-572 Carcinoma, Renal Cell Furthermore, miR-572 knockdown activated NF2/Hippo signaling pathway in RCC cells. +genetics_knock down_suppress 31949651 hsa-mir-148a Pancreatitis In addition, miR-148a-3p knockdown protected against cell necrosis, amylase, and lipase activity in AP. +lncRNA target 31949649 hsa-mir-106a Colorectal Neoplasms CONCLUSION: The up-regulation of miR-106a-5p contributes to the pathomechanism of colorectal cancer by promoting 5-FU resistance and metastasis via inhibiting target TGFbetaR2. +transcription factor target 31949646 hsa-mir-29b Hypertension, Pulmonary In conclusion, our results revealed that miR-29b plays an important role in collagen synthesis and may be a therapeutic target for PAH when regulated by the TGF-beta1/Smad3 pathway. +transcription factor target 31949646 hsa-mir-29 Hypertension, Pulmonary In conclusion, our results revealed that miR-29b plays an important role in collagen synthesis and may be a therapeutic target for PAH when regulated by the TGF-beta1/Smad3 pathway. +other 31949646 hsa-mir-29 Fibrosis MicroRNA29 (miR-29) is reported to be associated with diseases such as liver fibrosis, renal fibrosis, pulmonary fibrosis, and cardiac fibrosis in which collagen synthesis plays an important role. +other 31949646 hsa-mir-29 Pulmonary Fibrosis MicroRNA29 (miR-29) is reported to be associated with diseases such as liver fibrosis, renal fibrosis, pulmonary fibrosis, and cardiac fibrosis in which collagen synthesis plays an important role. +other 31949646 hsa-mir-29 Cardiomyopathies MicroRNA29 (miR-29) is reported to be associated with diseases such as liver fibrosis, renal fibrosis, pulmonary fibrosis, and cardiac fibrosis in which collagen synthesis plays an important role. +other 31949626 hsa-mir-16 Familial primary gastric lymphoma We detected the expression level of miRNA-16 in 91 patients with PGL by qPCR and analyzed the prognostic significance. These results suggest that miRNA-16 is a useful biomarker of disease prognosis in patients with PGL. +epigenetics 31949614 hsa-mir-375 Diabetes Mellitus, Type 2 Previously, our studies have shown that the hypomethylation of human miR-375 promoter may contribute to the pathogenesis of T2DM. +epigenetics 31949614 hsa-mir-375 Insulinoma To address this matter, we have analyzed the DNA methylation profile of insulinoma MIN6 cells by MassARRAY spectrometry and employed the DNA demethylating drug 5-aza-2'-deoxycytidine (5-aza-CdR) to treat MIN6 cells to explore the methylation patterns of the mmu-miR-375. +lncRNA target 31949606 hsa-mir-194 Osteosarcoma 3p suppresses migration and invasion of spinal osteosarcoma cells by targeting MMP-9, indicating miR +other 31949601 hsa-mir-210 Carcinoma, Endometrioid Taken together, we demonstrated that miR-210 could promote proliferation, migration and invasion by the negative regulation of NFIX expression in vitro, and that miR-210 promoted the progression of endometrial carcinoma by negative regulation NFIX expression. +other 31949575 hsa-let-7f Cardiotoxicity The angiogenic miRNAs let-7f and miR-126 might serve as novel and convincing biomarkers for reduced cardiotoxicity risk in TNBC patients who receive EC-D neoadjuvant chemotherapy. +other 31949575 hsa-mir-126 Cardiotoxicity The angiogenic miRNAs let-7f and miR-126 might serve as novel and convincing biomarkers for reduced cardiotoxicity risk in TNBC patients who receive EC-D neoadjuvant chemotherapy. +other 31949575 hsa-mir-126 Triple Negative Breast Neoplasms The angiogenic miRNAs let-7f and miR-126 might serve as novel and convincing biomarkers for reduced cardiotoxicity risk in TNBC patients who receive EC-D neoadjuvant chemotherapy. +other 31949575 hsa-let-7f Triple Negative Breast Neoplasms The angiogenic miRNAs let-7f and miR-126 might serve as novel and convincing biomarkers for reduced cardiotoxicity risk in TNBC patients who receive EC-D neoadjuvant chemotherapy. +lncRNA target 31949571 hsa-mir-148a Pancreatic Carcinoma Finally, biological study in two pancreatic cancer cell lines indicates that miR-148a function as a tumor suppressor gene through repressing pancreatic cancer cell proliferation, migration and invasion. We first identified miR-148a, which has down regulated expression in pancreatic cancer tissues, plays as a cancer inhibitor through targeting GLUT1. +other 31949526 hsa-mir-132 Cognitive Dysfunction CONCLUSION: MiRNAs expression showed low sensitivity and specificity in detecting MCI; only miRNA 132 might be used. +other 31949502 hsa-mir-3978 Peritoneal Diseases We have previously elucidated that the RNA-binding protein poly r(C) binding protein 1 (PCBP1) and miR-3978 function as repressors of peritoneal metastasis, partially by downregulation of six-transmembrane epithelial antigen of the prostate 1 (STEAP1). +genetics_overexpression_promote 31949497 hsa-mir-504 Pancreatic Carcinoma LINC00673 negatively correlated with miR-504 and MiR-504 overexpression promoted cancer progression in Pancreatic cancer. +genetics_overexpression_promote 31949489 hsa-mir-129 Lung Neoplasms Conclusion: Overexpression of expression miR +other 31949464 hsa-mir-542 Coronary Artery Disease 3p/GABARAP axis is required for Granule of BU-XIN RUAN-MAI, exhibiting its protective activity against the pectoris of coronary heart disease. +other 31949464 hsa-mir-542 Coronary Disease 3p/GABARAP axis is required for Granule of BU-XIN RUAN-MAI, exhibiting its protective activity against the pectoris of coronary heart disease. +lncRNA target 31949128 hsa-mir-26b Carcinoma, Hepatocellular Besides, DLGAP1-AS1 was proven to serve as a molecular sponge to sequester the HCC-inhibitory miRNAs, miR-26a-5p and miR-26b-5p, thus enhancing the level of an oncogenic cytokine IL-6, which could activate JAK2/STAT3 signaling pathway and reciprocally elevate the transcriptional activity of DLGAP1-AS1, thus forming a positive feedback loop. Moreover, we elaborated that the cancerogenic effects of DLGAP1-AS1 in HCC cells could be effectuated via activating Wnt/beta-catenin pathway by positively regulating CDK8 and LRP6, downstream genes of miR-26a/b-5p. +other 31948856 hsa-mir-126 Diabetes Mellitus, Type 2 RESULT: In this study, the expression level of miR-181b and miRp decreased gradually in pre-diabetic as well as T2DM subjects compared to healthy controls. +genetics_knock down_promote 31948764 hsa-mir-433 Osteosarcoma Moreover, the suppresive effect of SNHG14 knockdown on osteosarcoma cell proliferation, invasion and migration was attenuated by miR +other 31948751 hsa-mir-10b Atrial Premature Complexes These results might give a hint on the role of miR-10b and HAS3 during NETD of PCa cells. +other 31948751 hsa-mir-29a Pituitary Diseases This study aimed to explore the possible relevance and function of the transmembrane Hyaluronan Synthase 3 (HAS3) and miR-10b as well as miR-29a during NETD. Here, we validated a repression of HAS3 and an induction of miR-10b and miR-29a by quantitative real-time PCR after NETD. +other 31948751 hsa-mir-10b Pituitary Diseases These results might give a hint on the role of miR-10b and HAS3 during NETD of PCa cells. +circulation_biomarker_diagnosis_up 31948528 hsa-mir-155 Bronchopulmonary Dysplasia Compared with the model group, the low-, middle-, and high-dose asiaticoside groups and the budesonide group had significant improvement in the above symptoms of bronchopulmonary dysplasia, significant reductions in MLI, MDA level in lung tissue, serum levels of IL-6 and TNF-alpha, and miR-155 level in lung tissue (P<0.05), and significant increases in RAC, SOD level, and mRNA and protein expression of SOCS1 in lung tissue (P<0.05). +circulation_biomarker_diagnosis_up 31948528 hsa-mir-155 Hyperoxia-Induced Lung Injury Compared with the model group, the low-, middle-, and high-dose asiaticoside groups and the budesonide group had significant improvement in the above symptoms of bronchopulmonary dysplasia, significant reductions in MLI, MDA level in lung tissue, serum levels of IL-6 and TNF-alpha, and miR-155 level in lung tissue (P<0.05), and significant increases in RAC, SOD level, and mRNA and protein expression of SOCS1 in lung tissue (P<0.05). +circulation_biomarker_diagnosis_up 31948520 hsa-mir-495 Bronchopulmonary Dysplasia 5p in serum (P<0.05). +lncRNA target 31948396 hsa-mir-150 Cholangitis, Biliary, Primary CONCLUSION: This study convincingly report, that AMA-negative PBC is characterized by notable alternations of miR-21 and miR-150 and their downstream targets compared to AMA-positive patients underlining their possible importance in the induction of the disease and its progression to fibrosis. +lncRNA target 31948396 hsa-mir-150 Liver Cirrhosis CONCLUSION: This study convincingly report, that AMA-negative PBC is characterized by notable alternations of miR-21 and miR-150 and their downstream targets compared to AMA-positive patients underlining their possible importance in the induction of the disease and its progression to fibrosis. +lncRNA target 31948396 hsa-mir-21 Liver Cirrhosis CONCLUSION: This study convincingly report, that AMA-negative PBC is characterized by notable alternations of miR-21 and miR-150 and their downstream targets compared to AMA-positive patients underlining their possible importance in the induction of the disease and its progression to fibrosis. +lncRNA target 31948396 hsa-mir-21 Cholangitis, Biliary, Primary CONCLUSION: This study convincingly report, that AMA-negative PBC is characterized by notable alternations of miR-21 and miR-150 and their downstream targets compared to AMA-positive patients underlining their possible importance in the induction of the disease and its progression to fibrosis. +transcription factor target 31947624 hsa-mir-148a Distal myopathy, Nonaka type Firstly, we found the expression of miR-148a-5p is significantly decreased following DTMUV infect. Lastly, our experimental results showed that TLR3 was one of the causes of miR-148a-5p reduction, suggesting that the high level of TLR3 after DTMUV infect can both trigger innate immunity and suppress miR-148a-5p to resist DTMUV. +other 31947507 hsa-mir-204 Lung Neoplasms 3p) exhibited altered levels in lung cancer MDR cells and their EVs. +other 31947507 hsa-mir-204 Neoplasm, Residual 3p) exhibited altered levels in lung cancer MDR cells and their EVs. +other 31945729 hsa-mir-1252 Ovarian Neoplasms In this study, we explored the specific mechanisms of PTX resistance and tumor progress of ovarian cancer due to circCELSR1; presented the circCELSR1-miRFOXR2 axis and its role in ovarian cancer drug sensitivity and progression; and suggest that the results may provide an experimental basis for clinical application. +other 31945728 hsa-mir-708 Breast Neoplasms 5p expression and activity. +lncRNA target 31945725 hsa-mir-144 Anemia, Aplastic Therefore, the targeting of miR +transcription factor target 31945680 hsa-mir-29a Myocardial Reperfusion Injury CONCLUSIONS: MiR-29a in bone marrow-derived mesenchymal stem cells inhibits follistatin-like 1 secretion and promotes myocyte apoptosis by suppressing the JAK2/STAT3 pathway in hypoxia-reoxygenation injury. +circulation_biomarker_diagnosis_up 31945658 hsa-mir-155 Toxoplasmosis, Ocular 5p, miR-29c-3p and miR-125b-5p in plasma of 51 patients with ocular toxoplasmosis (OT Group), 26 individuals with asymptomatic toxoplasmosis (AT Group), and 25 healthy individuals seronegative for toxoplasmosis (NC Group). +circulation_biomarker_diagnosis_up 31945658 hsa-mir-146a Toxoplasmosis, Ocular 5p, miR-29c-3p and miR-125b-5p in plasma of 51 patients with ocular toxoplasmosis (OT Group), 26 individuals with asymptomatic toxoplasmosis (AT Group), and 25 healthy individuals seronegative for toxoplasmosis (NC Group). +circulation_biomarker_diagnosis_up 31945658 hsa-mir-29c Toxoplasmosis, Ocular 5p, miR-29c-3p and miR-125b-5p in plasma of 51 patients with ocular toxoplasmosis (OT Group), 26 individuals with asymptomatic toxoplasmosis (AT Group), and 25 healthy individuals seronegative for toxoplasmosis (NC Group). +circulation_biomarker_diagnosis_up 31945658 hsa-mir-125b Toxoplasmosis, Ocular 5p, miR-29c-3p and miR-125b-5p in plasma of 51 patients with ocular toxoplasmosis (OT Group), 26 individuals with asymptomatic toxoplasmosis (AT Group), and 25 healthy individuals seronegative for toxoplasmosis (NC Group). +circulation_biomarker_diagnosis_up 31945658 hsa-mir-21 Toxoplasmosis, Ocular 5p, miR-29c-3p and miR-125b-5p in plasma of 51 patients with ocular toxoplasmosis (OT Group), 26 individuals with asymptomatic toxoplasmosis (AT Group), and 25 healthy individuals seronegative for toxoplasmosis (NC Group). +other 31945549 hsa-mir-7112 Colorectal Neoplasms In addition, miR3p was highly expressed in CRC tissues compared with peripheral tissues. +lncRNA target 31945231 hsa-mir-181a-1 Iron Metabolism Disorders The aim of the present study was to investigate the roles of the necrotic gene cytochrome b-245 beta chain (Cybb); Cybb-related microRNA miR139-3p; the autophagy gene Beclin-1 (Becn1); proapoptotic genes Fas, Faslg and growth arrest and DNA-damage-inducible 45 alpha (Gadd45a); and apoptosis-related microRNA miR181a-1 levels on I/R injury, as well as, the potential protective effects of PostC through this gene and microRNAs. RESULTS: Although an increase was observed in the expression levels of the Cybb, Fas, Faslg and Gadd45a genes, the miR139-3p, miR181a-1, and Becn1 expression levels were found to decrease with I/R injury. +lncRNA target 31945231 hsa-mir-139 Iron Metabolism Disorders The aim of the present study was to investigate the roles of the necrotic gene cytochrome b-245 beta chain (Cybb); Cybb-related microRNA miR139-3p; the autophagy gene Beclin-1 (Becn1); proapoptotic genes Fas, Faslg and growth arrest and DNA-damage-inducible 45 alpha (Gadd45a); and apoptosis-related microRNA miR181a-1 levels on I/R injury, as well as, the potential protective effects of PostC through this gene and microRNAs. RESULTS: Although an increase was observed in the expression levels of the Cybb, Fas, Faslg and Gadd45a genes, the miR139-3p, miR181a-1, and Becn1 expression levels were found to decrease with I/R injury. +circulation_biomarker_diagnosis_up 31945196 hsa-mir-125b Toxoplasmosis, Cerebral 5p, miR-125b-5p and miR-29c-3p were tested in 79 plasma divided into groups: 32 CT/HIV patients; 27 individuals with asymptomatic toxoplasmosis (AT); and 20 individuals seronegative for toxoplasmosis (NC). +circulation_biomarker_diagnosis_up 31945196 hsa-mir-29c Acquired Immunodeficiency Syndrome 5p, miR-125b-5p and miR-29c-3p were tested in 79 plasma divided into groups: 32 CT/HIV patients; 27 individuals with asymptomatic toxoplasmosis (AT); and 20 individuals seronegative for toxoplasmosis (NC). +circulation_biomarker_diagnosis_up 31945196 hsa-mir-146a Toxoplasmosis, Cerebral 5p, miR-125b-5p and miR-29c-3p were tested in 79 plasma divided into groups: 32 CT/HIV patients; 27 individuals with asymptomatic toxoplasmosis (AT); and 20 individuals seronegative for toxoplasmosis (NC). +circulation_biomarker_diagnosis_up 31945196 hsa-mir-29c Toxoplasmosis, Cerebral 5p, miR-125b-5p and miR-29c-3p were tested in 79 plasma divided into groups: 32 CT/HIV patients; 27 individuals with asymptomatic toxoplasmosis (AT); and 20 individuals seronegative for toxoplasmosis (NC). +circulation_biomarker_diagnosis_up 31945196 hsa-mir-155 Acquired Immunodeficiency Syndrome 5p, miR-125b-5p and miR-29c-3p were tested in 79 plasma divided into groups: 32 CT/HIV patients; 27 individuals with asymptomatic toxoplasmosis (AT); and 20 individuals seronegative for toxoplasmosis (NC). +circulation_biomarker_diagnosis_up 31945196 hsa-mir-155 Toxoplasmosis, Cerebral 5p, miR-125b-5p and miR-29c-3p were tested in 79 plasma divided into groups: 32 CT/HIV patients; 27 individuals with asymptomatic toxoplasmosis (AT); and 20 individuals seronegative for toxoplasmosis (NC). +circulation_biomarker_diagnosis_up 31945196 hsa-mir-125b Acquired Immunodeficiency Syndrome 5p, miR-125b-5p and miR-29c-3p were tested in 79 plasma divided into groups: 32 CT/HIV patients; 27 individuals with asymptomatic toxoplasmosis (AT); and 20 individuals seronegative for toxoplasmosis (NC). +circulation_biomarker_diagnosis_up 31945196 hsa-mir-21 Toxoplasmosis, Cerebral 5p, miR-125b-5p and miR-29c-3p were tested in 79 plasma divided into groups: 32 CT/HIV patients; 27 individuals with asymptomatic toxoplasmosis (AT); and 20 individuals seronegative for toxoplasmosis (NC). +circulation_biomarker_diagnosis_up 31945196 hsa-mir-146a Acquired Immunodeficiency Syndrome 5p, miR-125b-5p and miR-29c-3p were tested in 79 plasma divided into groups: 32 CT/HIV patients; 27 individuals with asymptomatic toxoplasmosis (AT); and 20 individuals seronegative for toxoplasmosis (NC). +circulation_biomarker_diagnosis_up 31945196 hsa-mir-21 Acquired Immunodeficiency Syndrome 5p, miR-125b-5p and miR-29c-3p were tested in 79 plasma divided into groups: 32 CT/HIV patients; 27 individuals with asymptomatic toxoplasmosis (AT); and 20 individuals seronegative for toxoplasmosis (NC). +other 31944556 hsa-mir-136 Carcinoma, Hepatocellular 5p, was correlated with low overall survival of HCC patients. +lncRNA target 31944167 hsa-mir-192 Peripheral Nerve Injuries Bioinformatics analysis and dual-luciferase reporter gene assay confirmed the targeting relationship between miR +lncRNA target 31943867 hsa-mir-488 Thyroid Cancer, Papillary In conclusion, lncRNA CASC9 promoted the malignant phenotypes of PTC via modulating miR +genetics_knock down_promote 31943575 hsa-mir-520f Glioma TFAP4-66aa-uORF or miR-520f-3p overexpression or TFAP4, LASP1, or LINC00520 knockdown inhibited glioma cell proliferation, migration, and invasion, but promoted apoptosis. +circRNA target 31943342 hsa-mir-449c Stomach Neoplasms Circ-NOTCH1 promoted metastasis and stemness in GC through sponging miR-449c-5p. Above findings explained that circ-NOTCH1 promoted metastasis and stemness in GC by targeting miR-449c-5p/MYC/NOTCH1 axis, suggesting the possibility of circ-NOTCH1 as a therapeutic marker for GC. +genetics_overexpression_promote 31943339 hsa-mir-802 Stomach Neoplasms MiR-802 was demonstrated to be a tumor suppressor, and overexpression of miR-802 suppressed GC cell growth, migration, and invasion. +lncRNA target 31943174 hsa-mir-1301 Esophageal Squamous Cell Carcinoma Our findings indicated that MIAT promoted ESCC progression via targeting INCENP/miR +other 31943014 hsa-mir-486 Uterine Cervical Neoplasms lncRNA-PVT1 was upregulated by c-Myc and thus enhanced the proliferation of cervical cancer cells by sponging miR3p. +other 31942999 hsa-mir-101 Alzheimer Disease Finally, we identified a microRNA, hsa-miR3p, as a potential regulator of RAC1 in AD brains. +other 31942966 hsa-mir-155 Pancreatitis, Acute Necrotizing The aim of this study was to investigate the role and mechanism of miR-155 in regulating autophagy in a caerulein-induced acute pancreatitis (AP) cellular model. +other 31942966 hsa-mir-155 Autoimmune polyendocrinopathy syndrome, type 1 The aim of this study was to investigate the role and mechanism of miR-155 in regulating autophagy in a caerulein-induced acute pancreatitis (AP) cellular model. +transcription factor target 31942725 hsa-mir-4458 Cardiomegaly On the whole, these findings demonstrated that NRF1-induced miR-4458 boosted TFAM via targeting TTP to dampen the exacerbation of cardiac hypertrophy, which indicates miR-4458 as a promising biomarker for the cardiac hypertrophy treatment. +genetics_overexpression_promote 31942724 hsa-mir-127 Uterine Cervical Neoplasms 5p mimics or RPP25 insufficiency could offset the encouraging effects of LINC00319 overexpression on migration, invasion and EMT process in cervical cancer. +exosome 31942592 hsa-mir-497 Lung Neoplasms To mimic the in vivo-like tumor microenvironment of NSCLC, A549 cells were co-cultured with HUVECs in a single device, and miRloaded exosomes were delivered to both types of cells. +exosome 31942592 hsa-mir-497 Tuberculosis To mimic the in vivo-like tumor microenvironment of NSCLC, A549 cells were co-cultured with HUVECs in a single device, and miRloaded exosomes were delivered to both types of cells. +transcription factor target 31942587 hsa-mir-21 Breast Neoplasms Analysis of MCF-7 cells treated with toremifene (a potent inhibitor of breast cancer cell growth) revealed that the content of miRNA-21 decreased by ca. +circulation_biomarker_diagnosis_up 31942199 hsa-mir-144 Squamous Cell Carcinoma of Head and Neck 3p were negatively correlated with the expression status of endoplasmic reticulum oxidoreduction +circulation_biomarker_prognosis_up 31942186 hsa-mir-122 Carcinoma, Hepatocellular Conclusions: Serum exosomal miR-122 was a novel potential diagnostic and prognostic biomarker in CRC patients with LM. +circulation_biomarker_prognosis_up 31942186 hsa-mir-122 Colorectal Neoplasms Conclusions: Serum exosomal miR-122 was a novel potential diagnostic and prognostic biomarker in CRC patients with LM. +lncRNA target 31942183 hsa-mir-1228 Ovarian Neoplasms Conclusion: CircRNA_100395 could inhibit cell growth and metastasis of ovarian cancer cells via regulating the miR-1228/p53/EMT axis. +genetics_GWAS 31942037 hsa-mir-298 Alzheimer Disease Moreover, we identified two miR-298 SNPs associated with higher cerebrospinal fluid (CSF) p-tau and lower CSF Abeta42 levels in a cohort of human AD patients. +other 31942011 hsa-mir-27a Lichen Planus, Oral Although some studies have demonstrated that miR-27b is down-regulated in the oral specimens of patients suffering with oral lichen planus (OLP), the molecular mechanism of miR-27b decrease remains a large mystery, and the expression of miR-27a in OLP is not well explored. In sum, our results show that vitamin D/VDR signaling induces miR-27a/b in oral lichen planus. +other 31942011 hsa-mir-27b Lichen Planus, Oral Although some studies have demonstrated that miR-27b is down-regulated in the oral specimens of patients suffering with oral lichen planus (OLP), the molecular mechanism of miR-27b decrease remains a large mystery, and the expression of miR-27a in OLP is not well explored. In sum, our results show that vitamin D/VDR signaling induces miR-27a/b in oral lichen planus. +transcription factor target 31941838 hsa-mir-543 Primary Myelofibrosis Our findings suggest miR-543 as a potentially novel biomarker for the prognosis of MF patients with a high risk of treatment resistance and as a potentially new target for the development of new treatment options. +transcription factor target 31941605 hsa-mir-29a Heart Injuries In conclusion, our findings demonstrated that GRA exerted an effective role against LPS-induced acute cardiac injury through impeding apoptosis and inflammation regulated by miR-29a. +genetics_overexpression_promote 31941603 hsa-mir-154 Glioma However, the influences of miR5p-suppressed proliferation, migration and invasion of glioma cells could be abolished by overexpressed PIWIL1. +other 31941509 hsa-mir-33a Lung Neoplasms Additionally, JPX upregulated Twist1 by competitively sponging miR-33a-5p and subsequently induced EMT and lung cancer cell invasion. +lncRNA target 31940247 hsa-mir-145 Stomach Neoplasms HuR axis in the progression of GC and indicate a potential target for GC therapy. +genetics_knock down_promote 31939714 hsa-mir-766 Adenocarcinoma of Lung Furthermore, knockdown of MAPK1 partly rescued the miR +lncRNA target 31939620 hsa-mir-542 Esophageal Squamous Cell Carcinoma These results demonstrated that miR5423p may promote the metastasis of esophageal cancer cells, and indicated that miR5423p may be a treatment target for esophageal cancer. +lncRNA target 31939611 hsa-mir-29b-1 Cicatrix, Hypertrophic MicroRNA (miR)29b15p was identified as a target of tsRNA23678 and was downregulated in hypertrophic scar fibroblasts, constituting a negative regulatory factor for scar formation. +other 31939284 hsa-mir-122 Liver Injury MicroRNA-122 (miR-122) is a hepatocyte-specific microRNA biomarker for drug-induced liver injury (DILI). We conclude that the DCL assay can accurately measure miR-122 to diagnose liver injury in humans and other species and can overcome microRNA stability and isomiR challenges. +transcription factor target 31939276 hsa-mir-200c Esophageal Squamous Cell Carcinoma Systemic intravenous treatment of metastatic breast cancer with the iMSNs loaded with siPlk1 and miR-200c resulted in a significant suppression of the primary tumor growth and in marked reduction of metastasis upon short light irradiation of the primary tumor. +transcription factor target 31939276 hsa-mir-200c Breast Neoplasms Systemic intravenous treatment of metastatic breast cancer with the iMSNs loaded with siPlk1 and miR-200c resulted in a significant suppression of the primary tumor growth and in marked reduction of metastasis upon short light irradiation of the primary tumor. +other 31939196 hsa-mir-130a Pituitary Neoplasms 3p (p = 0.026) were significantly under expressed as compared to functioning tumors. +other 31939196 hsa-mir-149 Pituitary Neoplasms 3p (p = 0.026) were significantly under expressed as compared to functioning tumors. +genetics_GWAS 31938895 hsa-mir-499a Uterine Cervical Neoplasms Moreover, overexpression of miR-499a significantly enhanced the proliferation, cell cycle progression, colony formation, apoptosis resistance, migration and invasion of cervical cancer cells, while inhibiting miR-499a showed the opposite effects. +lncRNA target 31938444 hsa-mir-483 Lung Neoplasms 5p inhibitor plays a role in lung cancer through targeting RBM5 to induce apoptosis. +virus_miRNA 31938442 ebv-mir-BART8 Nasopharyngeal Carcinoma Fifty-two percent of NPC demonstrated high level expression of EBV-miR-BART8-3p and its expression was significantly correlated with distant metastasis (P=0.006). +other 31938442 hsa-mir-182 Nasopharyngeal Carcinoma Fifty-one percent of NPC showed high level expression of miR-3182. Its expression was significantly correlated with distant metastasis (P=0.005). +other 31938439 hsa-mir-125b Hyperglycemia However, the roles of miR-125b in DR are still unclear. +circulation_biomarker_prognosis_ns 31938427 hsa-mir-101 Carcinoma, Non-Small-Cell Lung In conclusion, serum miR-101 might serve as a potential biomarker for detection and prognosis evaluation of NSCLC. +genetics_overexpression_promote 31938423 hsa-mir-27a Acute Lung Injury Functional analyses indicated that overexpression of miR-27a using miR-27a agomir (agomiR-27a) protected the animals from LPS-induced ALI through decreased pulmonary inflammation, decreased wet-to-dry weight ratio, and ameliorated lung histopathological changes. +transcription factor target 31938420 hsa-mir-182 Spinal Cord Injuries 5p may be a potential therapeutic target of SCI in the future. +lncRNA target 31938416 hsa-mir-551b Stomach Neoplasms We transfected SGC-7901 gastric cancer cells with miRNA non-sense sequences (NC group), miR-551b mimics (miR-551b mimic group), and miR-551b inhibitors (miR-551b inhibitor group) to investigate the role of miR-551b in autophagic apoptosis. +circulation_biomarker_prognosis_up 31938391 hsa-mir-342 Carcinoma, Non-Small-Cell Lung In conclusion, serum miR +circulation_biomarker_diagnosis_ns 31938374 hsa-mir-126 Sepsis Furthermore, serum miR3p concentration at this time point was correlated with the expression markers of systemic inflammation, bacterial infection, and renal and hepatic dysfunction. +circulation_biomarker_prognosis_ns 31938373 hsa-mir-141 Carcinoma, Non-Small-Cell Lung Further subtype's analysis showed that serum miR-141 level could only predict OS in lung adenocarcinoma patients but not in SCC patients. Circulating miR-141 may be a novel and promising biomarker for susceptibility, clinicopathologic features of NSCLC patients, as well as an independent prognosis factor in lung adenocarcinomas patients but not in SCC patients. +lncRNA target 31938372 hsa-mir-361 Carcinoma, Ovarian Epithelial 5p inhibited the EMT progression in EOC cells by targeting RPL22L1 and c-Met/Akt/mTOR signaling. +genetics_knock down_promote 31938365 hsa-mir-455 Colorectal Neoplasms Loss-of-function of TPT1 had a similar effect on CRC cell proliferation in vitro as gain-of-function of miR +other 31938359 hsa-mir-659 Leukemia, Myelogenous, Chronic, BCR-ABL Positive 3p which may be a promising approach for CML treatment. +genetics_overexpression_promote 31938338 hsa-mir-338 Colorectal Neoplasms 3p agomir significantly inhibited xenograft CRC tumor growth and reversed the effect of increased xenograft tumor growth induced from HCT116 with MACC1 overexpression. +other 31938323 hsa-mir-155 Pre-Eclampsia The increase of miR-210, miR-155 levels, sFlt-1 levels, and the decrease of VEGF levels in EOSP patients might be correlated with the failure of expectant treatment. +other 31938323 hsa-mir-210 Pre-Eclampsia The increase of miR-210, miR-155 levels, sFlt-1 levels, and the decrease of VEGF levels in EOSP patients might be correlated with the failure of expectant treatment. +genetics_knock down_promote 31938294 hsa-mir-155 Hidradenitis Suppurativa CONCLUSIONS: miR-155 downregulates the expression of NCSTN by binding NCSTN 3'UTR, providing a possible new mechanism of loss of NCSTN function in AI patients. hsa-miR-155 functions as a promoter in AI, and is a potential therapy target for AI. +genetics_knock down_promote 31938293 hsa-mir-217 Mucocutaneous Lymph Node Syndrome In conclusion, overexpressed miRNA-217 could inhibit KSFBs growth, and the underlying mechanism was mediated, at least partially, through the suppression of FN expression. +other 31938293 hsa-mir-217 Keloid But above all, miRNA-217 might play a potential therapeutic avenue for the treatment of keloid fibrogenesis. +genetics_overexpression_promote 31938287 hsa-mir-24 Prostatic Neoplasms 3p and overexpression of SOCS6 reverses the effects of miR +other 31938286 hsa-mir-126 Rhinitis, Allergic 5p, miR-19a-5p and miR-26a-5p could serve as novel biomarker for AR risk. +other 31938286 hsa-mir-26a Rhinitis, Allergic 5p, miR-19a-5p and miR-26a-5p could serve as novel biomarker for AR risk. +other 31938286 hsa-mir-19a Rhinitis, Allergic 5p, miR-19a-5p and miR-26a-5p could serve as novel biomarker for AR risk. +genetics_GWAS 31938263 hsa-mir-34a Diabetes Mellitus Three SNPs (rs12128240, rs2666433, rs6577555) in miR-34a were analyzed in the T2DM patients with or without DN and normal controls. +transcription factor target 31938241 hsa-mir-21 Colorectal Neoplasms These findings may provide a theoretical basis for clarifying the physiological and pathological role of miR-21 in colorectal cancer. +genetics_overexpression_suppress 31938239 hsa-mir-128 Glioma Thus, our results suggest that overexpression of micro-RNA128 could increase the radio-sensitivity of glioma cells through Bmi-1. +other 31938234 hsa-mir-133b Osteoporosis 3p, miR-2861, miR-518 miR-100 were down-regulated osteoporotic patient, while miR-10b-5p, miR-21, miR-125b and miR-127 were up-regulated. +other 31938234 hsa-mir-100 Osteoporosis 3p, miR-2861, miR-518 miR-100 were down-regulated osteoporotic patient, while miR-10b-5p, miR-21, miR-125b and miR-127 were up-regulated. +other 31938234 hsa-let-7 Osteoporosis 3p, miR-2861, miR-518 miR-100 were down-regulated osteoporotic patient, while miR-10b-5p, miR-21, miR-125b and miR-127 were up-regulated. +other 31938234 hsa-mir-10b Osteoporosis 3p, miR-2861, miR-518 miR-100 were down-regulated osteoporotic patient, while miR-10b-5p, miR-21, miR-125b and miR-127 were up-regulated. +other 31938234 hsa-mir-28 Osteoporosis 3p, miR-2861, miR-518 miR-100 were down-regulated osteoporotic patient, while miR-10b-5p, miR-21, miR-125b and miR-127 were up-regulated. +other 31938234 hsa-mir-22 Osteoporosis 3p, miR-2861, miR-518 miR-100 were down-regulated osteoporotic patient, while miR-10b-5p, miR-21, miR-125b and miR-127 were up-regulated. +other 31938234 hsa-mir-2861 Osteoporosis 3p, miR-2861, miR-518 miR-100 were down-regulated osteoporotic patient, while miR-10b-5p, miR-21, miR-125b and miR-127 were up-regulated. +other 31938234 hsa-mir-21 Osteoporosis 3p, miR-2861, miR-518 miR-100 were down-regulated osteoporotic patient, while miR-10b-5p, miR-21, miR-125b and miR-127 were up-regulated. +other 31938234 hsa-let-7g Osteoporosis 3p, miR-2861, miR-518 miR-100 were down-regulated osteoporotic patient, while miR-10b-5p, miR-21, miR-125b and miR-127 were up-regulated. +other 31938234 hsa-mir-127 Osteoporosis 3p, miR-2861, miR-518 miR-100 were down-regulated osteoporotic patient, while miR-10b-5p, miR-21, miR-125b and miR-127 were up-regulated. +other 31938234 hsa-mir-125b Osteoporosis 3p, miR-2861, miR-518 miR-100 were down-regulated osteoporotic patient, while miR-10b-5p, miR-21, miR-125b and miR-127 were up-regulated. +lncRNA target 31938232 hsa-mir-520d Osteosarcoma A novel microRNA, miR-520d-5p, can inhibit proliferation of osteosarcoma cells, but the biological role of miR-520d-5p in lung cancer is notknown. +other 31938232 hsa-mir-520d Carcinoma, Non-Small-Cell Lung We investigated the roles of midazolam and miR-520d-5p in apoptosis induction in a non-small cell lung cancer (NSCLC) cell line (A549). +lncRNA target 31938232 hsa-mir-520d Lung Neoplasms A novel microRNA, miR-520d-5p, can inhibit proliferation of osteosarcoma cells, but the biological role of miR-520d-5p in lung cancer is notknown. We investigated the roles of midazolam and miR-520d-5p in apoptosis induction in a non-small cell lung cancer (NSCLC) cell line (A549). +genetics_overexpression_promote 31938212 hsa-mir-29 Carcinoma, Hepatocellular Furthermore, overexpression of IGF2BP1 attenuated the suppressive effects of miR-29 on the proliferation, migration, and invasion of HCC cells. +genetics_overexpression_promote 31938211 hsa-mir-944 Nasopharyngeal Carcinoma Overexpression of miR-944 significantly inhibited the cell migration and invasion in NPC 6-10B cells. +lncRNA target 31938208 hsa-mir-34a Carcinoma, Non-Small-Cell Lung miR-34a acted as a cancer suppressor in NSCLC via targeting the SIRT6. +lncRNA target 31938207 hsa-mir-490 Carcinoma, Hepatocellular 5p might directly target SRC, SRP9, PDGFRB, RPL28, or RPS23 and play an important role in HCC. +transcription factor target 31938197 hsa-mir-126 Benign Paroxysmal Positional Vertigo These findings suggest that miR-126 and spred-1 might serve as novel molecular targets for treating RNV-related ocular diseases. +transcription factor target 31938197 hsa-mir-126 Eye Diseases These findings suggest that miR-126 and spred-1 might serve as novel molecular targets for treating RNV-related ocular diseases. +circulation_biomarker_diagnosis_up 31938193 hsa-mir-15b Carcinoma, Hepatocellular In serum, the cluster of miR-(21 214 15b) classifier (AUC = 0.887) had a sensitivity of 80.3% and a specificity of 87.0% for HCC diagnosis. +genetics_knock down_promote 31938190 hsa-mir-132 Thyroid Neoplasms Overexpression or knockdown of miR-132/212 in thyroid cancer cells resulted in inhibited or enhanced proliferation. +circulation_biomarker_diagnosis_ns 31938164 hsa-mir-196a Carcinoma, Non-Small-Cell Lung The area under the curve (AUC) of serum miR-10a-5p and miR +circulation_biomarker_diagnosis_ns 31938164 hsa-mir-196 Carcinoma, Non-Small-Cell Lung The area under the curve (AUC) of serum miR-10a-5p and miR +circulation_biomarker_diagnosis_ns 31938164 hsa-mir-10a Carcinoma, Non-Small-Cell Lung The area under the curve (AUC) of serum miR-10a-5p and miR +transcription factor target 31938148 hsa-mir-10a late onset Parkinson's disease In conclusion, these results demonstrate that miR-10a may serve a functional role in alpha-syn-induced neuronal pathology by inhibiting expression of BCL2L11 and that upregulation of miR-10a expression may be a useful therapeutic strategy for the treatment of PD. +transcription factor target 31938138 hsa-mir-9 Colorectal Neoplasms Results suggest that miR-9 acts as a tumor suppressor in CRC progression by regulating CXCR4. +genetics_overexpression_promote 31938135 hsa-mir-483 Neuroblastoma Overexpression of miR +genetics_GWAS 31938129 hsa-mir-605 Lung Neoplasms The effects of miR-605 rs2043556 single nucleotide polymorphism (SNP) on the risk and prognosis of lung cancer are unclear. +transcription factor target 31938108 hsa-mir-627 Prostatic Neoplasms CONCLUSION: Collectively, miRNA-627 interrupts prostate cancer development as suppressing cell proliferation, migration and promoting cell apoptosis and tumor suppressor genes expression, which might provide promising therapeutic effect in the treatment of prostate cancer. +transcription factor target 31938100 hsa-mir-224 Hepatitis B Hence, the purpose of this study was to investigate the role of miR-224 in HBV infection and to determine whether its role depended on the miR-224/SIRT1/autophagy axis. In conclusion, these results suggest that miR-224 might hinder HBV replication through attenuating SIRT1-mediated autophagy, thereby these findings open a new avenue for the treatment of HBV infection. +lncRNA target 31938100 hsa-mir-224 Hepatitis B, Chronic In conclusion, these results suggest that miR-224 might hinder HBV replication through attenuating SIRT1-mediated autophagy, thereby these findings open a new avenue for the treatment of HBV infection. +epigenetics 31938095 hsa-mir-145 Carcinoma, Renal Cell In addition, we revealed that miR-145 down-regulation in ccRCC cells was due to EZH2-mediated histone methylation. +transcription factor target 31938092 hsa-mir-222 Pre-Eclampsia Altogether, the present study found that upregulation of miR-222 promotes apoptosis of mesenchymal stem cells in preeclampsia patients in response to hypoxia, via targeting BCL2L11. +other 31938084 hsa-mir-21 Myocardial Ischemia MiRNA-21 promotes the differentiation of MSCs, which may pave the way for the treatment directed toward restoring miRNA-21 function for myocardial ischemia. +lncRNA target 31938073 hsa-mir-204 Squamous Cell Carcinoma of Head and Neck 5p as a tumor suppressor is commonly repressed in HNSCC, which can inhibit tumor growth, metastasis and stemness. +lncRNA target 31938072 hsa-mir-142a Diabetic Nephropathies Furthermore, the atrophy of gastrocnemius induced by denervation was relieved through targeting miR-142a-5p/MFN1 axis. Conclusions: Collectively, our data revealed that miR-142a-5p was able to function as an important regulator of denervation-induced skeletal muscle atrophy by inducing mitochondrial dysfunction, mitophagy, and apoptosis via targeting MFN1. +lncRNA target 31938072 hsa-mir-142a Muscular Atrophy Furthermore, the atrophy of gastrocnemius induced by denervation was relieved through targeting miR-142a-5p/MFN1 axis. Conclusions: Collectively, our data revealed that miR-142a-5p was able to function as an important regulator of denervation-induced skeletal muscle atrophy by inducing mitochondrial dysfunction, mitophagy, and apoptosis via targeting MFN1. +lncRNA target 31938057 hsa-mir-9 Pancreatic Carcinoma Results: PL-1/miR-9 nanocomplexes dramatically improve the anticancer effect of doxorubicin through downregulating eIF5A2 expression to inhibit autophagy and induce apoptosis in PDAC therapy in vivo. +genetics_knock down_promote 31938051 hsa-mir-1956 Myocardial Infarction Gain- and loss-of-function studies allowed the validation of miR-1956 (enriched in MI Exo) as the functional messenger that stimulates ADMSCs-mediated angiogenesis and paracrine VEGF signaling, by downregulating Notch-1. Conclusions: Cardio-renal exosomes deliver miR-1956 and activate paracrine proangiogenic VEGF signaling in ADMSCs after MI; this process also involves Notch-1, which functions as the core mediator. +genetics_knock down_promote 31938022 hsa-mir-17 Squamous Cell Carcinoma of Head and Neck Mechanically, knockdown of miR +lncRNA target 31938021 hsa-let-7b Breast Neoplasms CONCLUSION: In agreement with these observations, we could reach a conclusion that CDX2 could promote let-7b expression, which may exert an inhibitory effect on the proliferation, migration, and metastasis of breast cancer cells via repressing the expression of COL11A1, providing a novel therapeutic strategy for the treatment of metastatic breast cancer. +lncRNA target 31938018 hsa-mir-483 Prostatic Neoplasms Additionally, the suppression on PCa cell proliferation, migration and invasion was induced by up-regulation of TSPYL5 or inhibition of miR +circulation_biomarker_diagnosis_ns 31937854 hsa-mir-375 Prostatic Neoplasms, Castration-Resistant Plasma levels of miR +other 31937830 hsa-mir-545 Pneumonia miR3p and miR-519c-3p, which separated AECOPD and CAP. +other 31937830 hsa-mir-545 Community-Acquired Pneumonia miR3p and miR-519c-3p, which separated AECOPD and CAP. +other 31937830 hsa-mir-519c Community-Acquired Pneumonia miR3p and miR-519c-3p, which separated AECOPD and CAP. +other 31937830 hsa-mir-519c Pneumonia miR3p and miR-519c-3p, which separated AECOPD and CAP. +other 31937590 hsa-mir-451a Peripheral Nervous System Diseases CONCLUSION: MiR-451a could be a predictive marker for PN caused by paclitaxel-containing chemotherapy; however, further investigation of the underlying mechanism is required to determine the role of miR-451a. +other 31936850 hsa-mir-205 Prostatic Neoplasms Eight of the miRNAs found in urine vesicles (miR-19b, miR-30e, miR-31, miR-92a, miR-125, miR-200, miR-205, and miR-660) showed great promise and when combined into six ratios (miR-125b/miR-30e, miR-200/miR-30e, miR-205/miR-30e, miR-31/miR-30e, miR-660/miR-30e, and miR-19b/miR-92a) could classify patients with prostate cancer, benign prostate hyperplasia, and healthy donors with 100% specificity, 100% sensitivity, and with a high degree of reliability for most donors. +other 31936850 hsa-mir-92a Prostatic Neoplasms Eight of the miRNAs found in urine vesicles (miR-19b, miR-30e, miR-31, miR-92a, miR-125, miR-200, miR-205, and miR-660) showed great promise and when combined into six ratios (miR-125b/miR-30e, miR-200/miR-30e, miR-205/miR-30e, miR-31/miR-30e, miR-660/miR-30e, and miR-19b/miR-92a) could classify patients with prostate cancer, benign prostate hyperplasia, and healthy donors with 100% specificity, 100% sensitivity, and with a high degree of reliability for most donors. +other 31936850 hsa-mir-1 Prostatic Neoplasms Eight of the miRNAs found in urine vesicles (miR-19b, miR-30e, miR-31, miR-92a, miR-125, miR-200, miR-205, and miR-660) showed great promise and when combined into six ratios (miR-125b/miR-30e, miR-200/miR-30e, miR-205/miR-30e, miR-31/miR-30e, miR-660/miR-30e, and miR-19b/miR-92a) could classify patients with prostate cancer, benign prostate hyperplasia, and healthy donors with 100% specificity, 100% sensitivity, and with a high degree of reliability for most donors. +other 31936850 hsa-mir-200 Prostatic Neoplasms Eight of the miRNAs found in urine vesicles (miR-19b, miR-30e, miR-31, miR-92a, miR-125, miR-200, miR-205, and miR-660) showed great promise and when combined into six ratios (miR-125b/miR-30e, miR-200/miR-30e, miR-205/miR-30e, miR-31/miR-30e, miR-660/miR-30e, and miR-19b/miR-92a) could classify patients with prostate cancer, benign prostate hyperplasia, and healthy donors with 100% specificity, 100% sensitivity, and with a high degree of reliability for most donors. +other 31936850 hsa-mir-125b Prostatic Neoplasms Eight of the miRNAs found in urine vesicles (miR-19b, miR-30e, miR-31, miR-92a, miR-125, miR-200, miR-205, and miR-660) showed great promise and when combined into six ratios (miR-125b/miR-30e, miR-200/miR-30e, miR-205/miR-30e, miR-31/miR-30e, miR-660/miR-30e, and miR-19b/miR-92a) could classify patients with prostate cancer, benign prostate hyperplasia, and healthy donors with 100% specificity, 100% sensitivity, and with a high degree of reliability for most donors. +other 31936850 hsa-mir-660 Prostatic Neoplasms Eight of the miRNAs found in urine vesicles (miR-19b, miR-30e, miR-31, miR-92a, miR-125, miR-200, miR-205, and miR-660) showed great promise and when combined into six ratios (miR-125b/miR-30e, miR-200/miR-30e, miR-205/miR-30e, miR-31/miR-30e, miR-660/miR-30e, and miR-19b/miR-92a) could classify patients with prostate cancer, benign prostate hyperplasia, and healthy donors with 100% specificity, 100% sensitivity, and with a high degree of reliability for most donors. +other 31936850 hsa-mir-19b Prostatic Neoplasms Eight of the miRNAs found in urine vesicles (miR-19b, miR-30e, miR-31, miR-92a, miR-125, miR-200, miR-205, and miR-660) showed great promise and when combined into six ratios (miR-125b/miR-30e, miR-200/miR-30e, miR-205/miR-30e, miR-31/miR-30e, miR-660/miR-30e, and miR-19b/miR-92a) could classify patients with prostate cancer, benign prostate hyperplasia, and healthy donors with 100% specificity, 100% sensitivity, and with a high degree of reliability for most donors. +other 31936850 hsa-mir-125 Prostatic Neoplasms Eight of the miRNAs found in urine vesicles (miR-19b, miR-30e, miR-31, miR-92a, miR-125, miR-200, miR-205, and miR-660) showed great promise and when combined into six ratios (miR-125b/miR-30e, miR-200/miR-30e, miR-205/miR-30e, miR-31/miR-30e, miR-660/miR-30e, and miR-19b/miR-92a) could classify patients with prostate cancer, benign prostate hyperplasia, and healthy donors with 100% specificity, 100% sensitivity, and with a high degree of reliability for most donors. +circulation_biomarker_diagnosis_ns 31936594 hsa-mir-125b Cerebrovascular Disorders We also examined the association between the vascular endothelial function and postpartum whole peripheral blood expression of microRNAs involved in pathogenesis of cardiovascular/cerebrovascular diseases (miR +circulation_biomarker_diagnosis_ns 31936594 hsa-mir-24 Cerebrovascular Disorders We also examined the association between the vascular endothelial function and postpartum whole peripheral blood expression of microRNAs involved in pathogenesis of cardiovascular/cerebrovascular diseases (miR +circulation_biomarker_diagnosis_up 31936594 hsa-mir-499a Ataxia with vitamin E deficiency At 10.0% FPR, a proportion of women with vascular endothelial dysfunction (RHI A-mediated disruption of hsa-miR +lncRNA target 31883160 hsa-mir-493 Liver Neoplasms 5p is a pivotal miRNA that modulates various oncogenes after its reexpression in liver cancer cells, suggesting that tumor suppressor miRNAs with a large spectrum of action could provide valuable tools for miRNA replacement therapies. +transcription factor target 31883144 hsa-mir-185 Lung Neoplasms Thus, as miR-34b and miR-185 participated in the suppression of P-gp functions in A549 cells they could be interesting targets for the treatment of lung cancer. +transcription factor target 31883144 hsa-mir-34b Lung Neoplasms Thus, as miR-34b and miR-185 participated in the suppression of P-gp functions in A549 cells they could be interesting targets for the treatment of lung cancer. +lncRNA target 31883035 hsa-mir-22 Reperfusion Injury, Cerebral Ischemia miR-22 exerts its neuroprotective and angiogenic functions via the PI3K/Akt signaling pathway, at least partly, in rats under cerebral ischemia-reperfusion. +other 31883035 hsa-mir-2 Reperfusion Injury, Cerebral Ischemia TTC staining showed increased percentage of cerebral infarction volume in the model and miR-22 control groups and this increase was reduced by miR-22. +other 31882882 hsa-mir-125a Skin Diseases The results obtained showed an increase in the expression of miRNAs recognized as regulators of the inflammatory response in skin lesions such as miR125a-5p and miR125b-5p. +other 31882882 hsa-mir-125b Skin Diseases The results obtained showed an increase in the expression of miRNAs recognized as regulators of the inflammatory response in skin lesions such as miR125a-5p and miR125b-5p. +circulation_biomarker_diagnosis_ns 31882721 hsa-mir-21 Pancreatitis During pancreatitis plasma exosomes, but not PAAF exosomes, are enriched in the inflammatory miR-155 and show low levels of miR-21 and miR-122. +circulation_biomarker_diagnosis_ns 31882721 hsa-mir-155 Pancreatitis During pancreatitis plasma exosomes, but not PAAF exosomes, are enriched in the inflammatory miR-155 and show low levels of miR-21 and miR-122. +circulation_biomarker_diagnosis_ns 31882721 hsa-mir-122 Pancreatitis During pancreatitis plasma exosomes, but not PAAF exosomes, are enriched in the inflammatory miR-155 and show low levels of miR-21 and miR-122. +lncRNA target 31882548 hsa-mir-140 Colorectal Neoplasms CONCLUSION: miR-140 regulates inflammatory cytokine secretion of LPS-induced colorectal cancer cells by targeting TRAF6. +other 31882540 hsa-mir-199a Starvation Transcriptional activity studies in MIN6 cells also revealed that primiR-199a2 promoter activity was enhanced by glucose and reduced by 2-deoxy-D-glucose-induced starvation. +other 31882540 hsa-mir-199 Starvation Transcriptional activity studies in MIN6 cells also revealed that primiR-199a2 promoter activity was enhanced by glucose and reduced by 2-deoxy-D-glucose-induced starvation. +circulation_biomarker_diagnosis_up 31882475 hsa-mir-375 Teratoma 3p does probably not qualify for a useful serum biomarker to distinguish teratoma from other GCTs and from controls. +other 31882471 hsa-mir-19a Gallbladder Neoplasms Two microRNA candidates (miR-19a-3p, and miR-19b-3p), which were identified by a literature review and computational analysis, were assessed in GBC tissue samples by quantitative real-time polymerase chain reaction. +other 31882471 hsa-mir-19b Gallbladder Neoplasms Two microRNA candidates (miR-19a-3p, and miR-19b-3p), which were identified by a literature review and computational analysis, were assessed in GBC tissue samples by quantitative real-time polymerase chain reaction. +other 31882470 hsa-mir-6321 Periodontitis CONCLUSION: miR-3591, miR-181a3p and miR-6321 induced hepatocyte apoptosis in our periodontitis rat model. +other 31882470 hsa-mir-591 Periodontitis CONCLUSION: miR-3591, miR-181a3p and miR-6321 induced hepatocyte apoptosis in our periodontitis rat model. +other 31882470 hsa-mir-181a-2 Periodontitis CONCLUSION: miR-3591, miR-181a3p and miR-6321 induced hepatocyte apoptosis in our periodontitis rat model. +other 31882423 hsa-mir-200a Colorectal Neoplasms RESULTS: The multivariate analysis indicates that 2 lncRNAs (WASIR2 and MIR31HG) and 2 miRNAs (hsa-mir-200a and hsa-mir-155) exhibited an independently significant prognostic value for stage II colon cancer. +other 31882423 hsa-mir-155 Colorectal Neoplasms RESULTS: The multivariate analysis indicates that 2 lncRNAs (WASIR2 and MIR31HG) and 2 miRNAs (hsa-mir-200a and hsa-mir-155) exhibited an independently significant prognostic value for stage II colon cancer. +other 31882423 hsa-mir-1 Colorectal Neoplasms RESULTS: The multivariate analysis indicates that 2 lncRNAs (WASIR2 and MIR31HG) and 2 miRNAs (hsa-mir-200a and hsa-mir-155) exhibited an independently significant prognostic value for stage II colon cancer. +circRNA target 31882179 hsa-mir-196b Prostatic Neoplasms In addition, hsa_circ_0001085 may indirectly regulate the PI3K-Akt signaling and TGF-beta signaling pathways through hsa-miR-196b-5p and the MAPK signaling pathway through has-miR-451a, which played a regulatory role in prostate cancer cells in the EMT induction model. +circRNA target 31882179 hsa-mir-451a Prostatic Neoplasms In addition, hsa_circ_0001085 may indirectly regulate the PI3K-Akt signaling and TGF-beta signaling pathways through hsa-miR-196b-5p and the MAPK signaling pathway through has-miR-451a, which played a regulatory role in prostate cancer cells in the EMT induction model. +transcription factor target 31881477 hsa-mir-125a Diabetes Mellitus, Type 2 CONCLUSIONS: Dioscin showed potent anti-T2DM activity by improving the inhibitory effect of miR-125a-5p on STAT3 signaling to alleviate glycolipid metabolic disorder of T2DM. +lncRNA target 31881378 hsa-mir-494 Arthritis These results indicated that FC-99 relieved macrophages inflammation via the miR-494/TN-C/NF-kappaB pathway, finally leading to the relief of inflammation in arthritis. +other 31881254 hsa-mir-181a Psychotic Disorders CONCLUSION: Our findings suggest that rs10760371 within miR-181a may relate to the development of MA dependence with psychosis. +genetics_overexpression_suppress 31881225 hsa-mir-139 Osteosarcoma 5p overexpression or knock-down and NOTCH1 knock-down cell models were constructed. +other 31881206 hsa-mir-200c Hypertension The miRNA-200c-3p/ZEB2 axis will provide valuable insights into the clinical management of hypertension-related kidney disease. +other 31881206 hsa-mir-200c Kidney Diseases The present study aimed to explore the expression status and putative role of miRNA-200c-3p in mediating the progression of hypertensive renal damage. The miRNA-200c-3p/ZEB2 axis will provide valuable insights into the clinical management of hypertension-related kidney disease. +other 31881206 hsa-mir-200c Renal Artery Obstruction We carried out real-time quantitative PCR (RT-qPCR) to detect the expression of miRNA-200c-3p in rat renal artery endothelial cells (RRAECs) induced by Ang II. +other 31881206 hsa-mir-200c Hypertension, Renal The present study aimed to explore the expression status and putative role of miRNA-200c-3p in mediating the progression of hypertensive renal damage. +circulation_biomarker_diagnosis_up 31881168 hsa-mir-181b Irritable Bowel Syndrome The aim of this study was to determine whether miR-23a and miR-181b were suitable as biomarkers of irritable bowel syndrome (IBS) and colorectal cancer (CRC). The serum levels of miR-23a and miR-181b were significantly higher in the IBS group (p = 0.0009 and 0.004, respectively) and CRC group (p = 0.002 and 0.029, respectively) than in the control group. +circulation_biomarker_diagnosis_up 31881168 hsa-mir-181b Colorectal Neoplasms The aim of this study was to determine whether miR-23a and miR-181b were suitable as biomarkers of irritable bowel syndrome (IBS) and colorectal cancer (CRC). The serum levels of miR-23a and miR-181b were significantly higher in the IBS group (p = 0.0009 and 0.004, respectively) and CRC group (p = 0.002 and 0.029, respectively) than in the control group. +circulation_biomarker_diagnosis_up 31881168 hsa-mir-23a Irritable Bowel Syndrome The aim of this study was to determine whether miR-23a and miR-181b were suitable as biomarkers of irritable bowel syndrome (IBS) and colorectal cancer (CRC). The serum levels of miR-23a and miR-181b were significantly higher in the IBS group (p = 0.0009 and 0.004, respectively) and CRC group (p = 0.002 and 0.029, respectively) than in the control group. +circulation_biomarker_diagnosis_up 31881168 hsa-mir-23a Colorectal Neoplasms The aim of this study was to determine whether miR-23a and miR-181b were suitable as biomarkers of irritable bowel syndrome (IBS) and colorectal cancer (CRC). The serum levels of miR-23a and miR-181b were significantly higher in the IBS group (p = 0.0009 and 0.004, respectively) and CRC group (p = 0.002 and 0.029, respectively) than in the control group. +genetics_overexpression_promote 31881106 hsa-mir-647 Glioma HOXA9 was validated a direct target of miR-647 and the overexpression of HOXA9 reversed the effects of miR-647 on glioma cell behavior. +transcription factor target 31881012 hsa-mir-27b Cardiomyopathies Importantly, inhibition of miR-27b abrogated the coronary artery ligation (CAL) induced cardiac fibrosis in vivo, suggesting that it might be a potential target for the treatment of fibrosis associated cardiac diseases. +lncRNA target 31880528 hsa-mir-101 Stomach Neoplasms 3p inhibits the proliferation and invasion of GC cells, and promotes their apoptosis by regulation of the expression of PIM-1. +lncRNA target 31880390 hsa-mir-211 Carcinoma, Hepatocellular 5p/NR1I3 axis participated in HBV-related HCC progression via interference with the cellular physiology of HCC. +genetics_GWAS 31880258 hsa-mir-143 Stomach Neoplasms CONCLUSION: For the first time, our results provide some evidence on the polymorphisms of miR-143HG associated with GC risk in the Chinese Han population. +genetics_overexpression_promote 31880114 hsa-mir-155 Lung Neoplasms Hsp70 overexpressed lung cancer cell line was established, the levels of microRNA-155 in A549 and hsp70 overexpressed A549 cell culture medium were determined by qRT-PCR.An in vitro blood-brain barrier model was established, and was treated with A549 cell culture medium collected at different hypoxia time points. +transcription factor target 31880039 hsa-mir-574 Esophageal Squamous Cell Carcinoma 3p inhibited proliferation, migration and invasion, and promoted apoptosis in esophageal cancer cells. +transcription factor target 31879991 hsa-mir-181a Diabetes Mellitus, Type 2 Thus, miR-181a/b-5p-mediated suppression of PDGFRA may be used as a therapeutic intervention in the management of type 2 diabetes. +transcription factor target 31879991 hsa-mir-181b Diabetes Mellitus, Type 2 Thus, miR-181a/b-5p-mediated suppression of PDGFRA may be used as a therapeutic intervention in the management of type 2 diabetes. +transcription factor target 31879968 hsa-mir-1249 Biliary Tract Neoplasms CONCLUSIONS: MIR1249 mediates resistance to CG in BTCs and may be tested as a target for therapeutics. +lncRNA target 31878998 hsa-mir-129-1 Nasopharyngeal Carcinoma 1-3p could reverse cisplatin resistance of HNE1/CDDP nasopharyngeal carcinoma cells via inhibiting WEE1 expression. +lncRNA target 31878995 hsa-let-7i Breast Neoplasms The findings suggest that let-7i may inhibit the resistance of drug-resistant breast cancer cells via inhibiting the expression of K-Ras and Bcl2. +transcription factor target 31878977 hsa-mir-21 Respiratory Distress Syndrome TCs culture medium enhanced hemangioendothelioma endothelial cells (EOMA cells) proliferation, which was blocked by the miR-21a-3p inhibitor. +lncRNA target 31878844 hsa-mir-221 Stroke Moreover, GAS5 and miR-221 have direct interaction and PUMA was the target of miR-221, indicating that GAS5 regulated PUMA through sponging miR-221.Conclusions: the present study revealed that GAS5 aggravated cell apoptosis in hypoxia condition via miR-221/PUMA axis, which may provide potential targets for the treatment of stroke. +other 31878844 hsa-mir-221 Ischemic Stroke Luciferase assay was applied to reveal the underlying relationship between GAS5 and miR-221 or p53-upregulated modulator of apoptosis (PUMA) and miR-221.Results: The results indicated that GAS5 was up-regulated in MCAO rats and in vitro hypoxia cell model while miR-221 expression was decreased in vitro hypoxia cell model. +lncRNA target 31878829 hsa-mir-124 Keloid Taken together, our findings revealed that HOXA11-AS inhibits cell apoptosis and promotes angiogenesis through miR +other 31878795 hsa-mir-106a Thyroid Cancer, Papillary First, the HULC and microRNA-106a (miR-106a) expressions in PTC tissues and cells were tested. We discovered that HULC and miR-106a had relative high expression levels in PTC tissues and cells. +lncRNA target 31878245 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck Moreover, by suppressing miR5p, STAT3, and mTOR expressions in CSC_EVs, OV re-sensitized CSCs to CDDP and suppressed OSCC tumorigenesis. +other 31878120 hsa-mir-210 Myocardial Infarction In agreement with a pro-angiogenic role, miR-210 also improved cardiac function and left ventricular remodeling after myocardial infarction. +lncRNA target 31877715 hsa-mir-20a Carcinoma, Hepatocellular The data showed that HGK induced the expression of the microRNA miR-320a, which in turn inhibited the expression of the transcription factor 'forkhead box protein M1' (FOXM1) and downstream FOXM1-regulated proteins related to epithelial-mesenchymal transition, thereby leading to the suppression of liver cancer cell growth and invasion. +circulation_biomarker_diagnosis_ns 31877644 hsa-mir-1228 Colorectal Neoplasms 5p and the spike-in cel-miR-39 in a set of 297 plasmas (92 CRC, 101 advanced adenomas -AA-, and 100 controls) and 213 serum samples (59 CRC, 74 AA and 80 controls). +circulation_biomarker_diagnosis_ns 31877644 hsa-mir-16 Colorectal Neoplasms 5p and the spike-in cel-miR-39 in a set of 297 plasmas (92 CRC, 101 advanced adenomas -AA-, and 100 controls) and 213 serum samples (59 CRC, 74 AA and 80 controls). +lncRNA target 31877497 hsa-mir-181a Sepsis We demonstrated that CRNDE was markedly down-regulated while miR-181a-5p was significantly up-regulated in sepsis models. We concluded that CRNDE protected renal cell from sepsis-induced injury via miR-181a-5p/PPARalpha pathway. +lncRNA target 31877497 hsa-mir-181a Diabetic Nephropathies We demonstrated that CRNDE was markedly down-regulated while miR-181a-5p was significantly up-regulated in sepsis models. We concluded that CRNDE protected renal cell from sepsis-induced injury via miR-181a-5p/PPARalpha pathway. +lncRNA target 31877411 hsa-mir-155 Silicotuberculosis The sustained repression of meprin alpha and beneficial effects of its rescue by inhibition of miR +lncRNA target 31877332 hsa-mir-202 Neurologic Manifestations 5p may serve as a protective agent for ischemia-reperfusion injury in stroke via eIF4E. +lncRNA target 31877332 hsa-mir-202 Nerve Degeneration 5p may serve as a protective agent for ischemia-reperfusion injury in stroke via eIF4E. +lncRNA target 31877332 hsa-mir-202 Ischemic Stroke 5p may serve as a protective agent for ischemia-reperfusion injury in stroke via eIF4E. +lncRNA target 31877306 hsa-mir-200a Glaucoma Ultimately, we found that the components of the H19/miR-200a/beta-catenin regulatory axis were aberrantly expressed in a rat model of GFS. Our results show that H19 indeed acts by modulating beta-catenin expression via miR-200a in TGF-beta-treated HTFs, thus providing a novel rationale for the development of H19-based strategies to attenuate scar formation after GFS. +genetics_overexpression_promote 31877303 hsa-mir-200b Thyroid Cancer, Papillary Furthermore, xenograft experiments showed miR-200b/c overexpression constrained growth of PTC xenograft and EMT. +other 31877301 hsa-mir-485 Nervous System Diseases In recent years, the role of miR5p has been discovered in neurological diseases. +other 31877301 hsa-mir-485 Peripheral Nerve Injuries 5p was detected in sciatic nerve stumps by real-time PCR. +other 31877301 hsa-mir-485 Cranial Nerve Injuries 5p expression was downregulated post nerve injury. +genetics_overexpression_promote 31877121 hsa-mir-506 Pulpitis SIRT1 overexpression showed a similar inhibitory effect as that of miR-506 downregulation on inflammation and TLR4 activation in DPSCs. +genetics_GWAS 31876746 hsa-mir-23a Prostatic Neoplasms We found that miR-23a gene polymorphism rs3745453 carrying CC homozygotes had a 4.16-fold increased risk (95% CI = 1.30-13.25) than those carrying the TT/CT genotypes (P = .02), and the C allele displayed a higher prevalence of PCa than the T allele (OR = 1.68, 95% CI = 1.16-2.45, P = .01). +lncRNA target 31876684 hsa-mir-16 Alzheimer Disease 5p and miR-19b-3p relieved amyloid beta-induced injury by targeting BACE1 in SH-SY5Y cells, indicating miR +lncRNA target 31876684 hsa-mir-19b Alzheimer Disease 5p and miR-19b-3p relieved amyloid beta-induced injury by targeting BACE1 in SH-SY5Y cells, indicating miR +lncRNA target 31876683 hsa-mir-137 Glioblastoma The levels of HOTAIRM1 and specificity protein 1 were significantly increased while miR-137 was significantly decreased in glioblastoma tissues and cells. Downregulation of HOTAIRM1 expression suppressed the proliferation and invasion of glioblastoma cells by down-regulating specificity protein 1 expression via sponging miR-137, indicating a promising strategy for glioblastoma treatment. +other 31876555 hsa-mir-200c Pulmonary Arterial Hypertension Between-group comparison revealed miR-29a-3p, miR-26a-5p, miR5p, and miR-200c-3p as upregulated in pulmonary arterial hypertension-superior vena cava and miR-99a-5p as downregulated in pulmonary arterial hypertension-pulmonary artery. +other 31876555 hsa-mir-29a Pulmonary Arterial Hypertension Between-group comparison revealed miR-29a-3p, miR-26a-5p, miR5p, and miR-200c-3p as upregulated in pulmonary arterial hypertension-superior vena cava and miR-99a-5p as downregulated in pulmonary arterial hypertension-pulmonary artery. +other 31876555 hsa-mir-26a Pulmonary Arterial Hypertension Between-group comparison revealed miR-29a-3p, miR-26a-5p, miR5p, and miR-200c-3p as upregulated in pulmonary arterial hypertension-superior vena cava and miR-99a-5p as downregulated in pulmonary arterial hypertension-pulmonary artery. +other 31876555 hsa-mir-99a Pulmonary Arterial Hypertension Between-group comparison revealed miR-29a-3p, miR-26a-5p, miR5p, and miR-200c-3p as upregulated in pulmonary arterial hypertension-superior vena cava and miR-99a-5p as downregulated in pulmonary arterial hypertension-pulmonary artery. +other 31876555 hsa-mir-590 Pulmonary Arterial Hypertension Between-group comparison revealed miR-29a-3p, miR-26a-5p, miR5p, and miR-200c-3p as upregulated in pulmonary arterial hypertension-superior vena cava and miR-99a-5p as downregulated in pulmonary arterial hypertension-pulmonary artery. +lncRNA target 31876385 hsa-mir-129 Prostatic Neoplasms DR cells to docetaxel through suppressing CAMK2N1 expression, and thus targeting miR +other 31876226 hsa-mir-6723 Pancreatic Carcinoma The HOXB5 that bound two synergy motifs regulated miR-6723 expression and contributed to PC malignant progression. HOXB5 accelerated the malignant progression of PC by up-regulating miR-6723, which afforded PC cells stem-like properties and facilitated the epithelial-mesenchymal transition of PC cells. +other 31876058 hsa-mir-124 Asthma Additionally, lncRNA NEAT1 was negatively correlated with miR-124, and miR-124 was negatively associated with exacerbation risk, exacerbation severity, and inflammation, but positively associated with lung function in asthma patients. +lncRNA target 31875764 hsa-mir-210 Pancreatic Carcinoma At last, miRDB and TargetScan predicted that HOXA9 was a target of miR-210, and dual luciferase reporter assay verified this hypothesis.Conclusion: MiR-210 inhibited the expression of HOXA9 to activate the NF-kappaB signaling pathway and mediated the occurrence of EMT of pancreatic cancer cells induced by HIF-1alpha under hypoxia. +other 31875666 hsa-mir-26b Aortic Diseases CONCLUSION: The results of our study using models of aortic banding and debanding suggested that miRNA-26b was significantly increased after aortic debanding. +other 31875589 hsa-mir-192 Hyperglycemia In summary, the present study demonstrated that circHIPK3 contributes to hyperglycemia and insulin resistance by sponging miR5p and up-regulating FOXO1. +lncRNA target 31875548 hsa-mir-551b Triple Negative Breast Neoplasms Genomic amplification of 3q26.2 locus leads to the increased expression of microRNA 551b-3p (miR551b-3p) in triple-negative breast cancer (TNBC). Conversely, targeting miR551b with anti-miR551b-3p reduced the expression of the OSM signaling module and reduced tumor growth, as well as migration and invasion of breast cancer cells. +transcription factor target 31875420 hsa-mir-3177 Atherosclerosis Furthermore, in the miRNA/TF-target network, hsa-miR5p might be involved in the pathogenesis of -atherosclerosis via regulating BEST1, and the transcription factor early growth response-1 (EGR1) was found to be a potential promoter in atherogenesis. +genetics_knock down_promote 31875359 hsa-mir-4435-2 Carcinoma, Non-Small-Cell Lung Additionally, re-activation of TGF-beta1 rescued MIR4435-2HG knockdown-mediated inhibition on the progression of NSCLC cells. +genetics_overexpression_promote 31875034 hsa-mir-1229 Glioma And overexpression of miR +other 31875024 hsa-mir-548 Chorioamnionitis These results suggest miR-548 can alter the inflammatory responses in hAECs, and might be involved in the pathogenesis of preterm birth by regulating HMGB1. +other 31875024 hsa-mir-548 Premature Birth These results suggest miR-548 can alter the inflammatory responses in hAECs, and might be involved in the pathogenesis of preterm birth by regulating HMGB1. +circulation_biomarker_diagnosis_ns 31874934 hsa-mir-200c Colorectal Neoplasms However, MIR200C/MIR141 methylation showed differences between colorectal tissues and peripheral blood of CRC patients (p<0.0001) and mainly methylated alleles were observed in peripheral blood. +circulation_biomarker_diagnosis_ns 31874934 hsa-mir-141 Colorectal Neoplasms However, MIR200C/MIR141 methylation showed differences between colorectal tissues and peripheral blood of CRC patients (p<0.0001) and mainly methylated alleles were observed in peripheral blood. +other 31874343 hsa-mir-20a Acute Kidney Injury MiR-20a is involved in a variety of inflammatory reactions, but its role in AKI remains unknown. The purpose of this study was to investigate specific in vitro function and mechanisms of miR-20a in AKI. +other 31874245 hsa-mir-191 Prostatic Neoplasms Notably, this miR-191/RXRA interaction was conserved in a novel primary cell line derived from radiorecurrent prostate cancer. Together, our findings demonstrate that miR-191 promotes prostate cancer survival after radiotherapy, and highlights retinoids as a potential option to improve radiotherapy response. +transcription factor target 31874165 hsa-mir-184 Pulmonary Fibrosis SIGNIFICANCE: Inhibiting miR-31 and/or promoting miR-184 protect against TGF-beta-induced fibrogenesis by respectively repressing the TGF-beta-SMAD2 and TGF-beta-PI3K-AKT signaling pathways, implying that miR-31/184 are potential targets and suggesting a new management strategy for IPF. +transcription factor target 31874165 hsa-mir-1 Pulmonary Fibrosis SIGNIFICANCE: Inhibiting miR-31 and/or promoting miR-184 protect against TGF-beta-induced fibrogenesis by respectively repressing the TGF-beta-SMAD2 and TGF-beta-PI3K-AKT signaling pathways, implying that miR-31/184 are potential targets and suggesting a new management strategy for IPF. +genetics_GWAS 31873718 hsa-mir-204 Stomach Neoplasms Helicobacter pylori induced a progressive downregulation of microRNA-204 from superficial gastritis to intestinal metaplasia, with an accompanying increment of the methylated levels of CpG sites in the TRPM3 promoter. These results demonstrate that epigenetic silencing of microRNA-204 induced by H.pylori infection augments the NF-kappaB signaling pathway in H.pylori-induced gastritis and GC, potentially providing novel intervention targets for these diseases. +other 31873177 hsa-mir-148a Wasting Disease, Chronic Furthermore, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses pointed to a strong correlation for 3 of these miRNAs, miR-148a-3p, miR5p, miR-30e-3p, with prion disease. +other 31873177 hsa-mir-186 Wasting Disease, Chronic Furthermore, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses pointed to a strong correlation for 3 of these miRNAs, miR-148a-3p, miR5p, miR-30e-3p, with prion disease. +other 31873123 hsa-mir-182 Carcinoma, Hepatocellular Thus, AURKAPS1 could be a useful marker, and the combination of AURKAPS1/miRNAs (miR-142, miR-155 and miR-182) may be a new theoretical basis for the treatment of HCC. +other 31873123 hsa-mir-142 Carcinoma, Hepatocellular Thus, AURKAPS1 could be a useful marker, and the combination of AURKAPS1/miRNAs (miR-142, miR-155 and miR-182) may be a new theoretical basis for the treatment of HCC. +other 31873123 hsa-mir-155 Carcinoma, Hepatocellular Thus, AURKAPS1 could be a useful marker, and the combination of AURKAPS1/miRNAs (miR-142, miR-155 and miR-182) may be a new theoretical basis for the treatment of HCC. +transcription factor target 31873114 hsa-mir-192 Lung Neoplasms 5p inhibited the proliferation, migration and invasion of lung cancer through TRIM44. +lncRNA target 31873061 hsa-mir-22 Obesity 3p inhibition could become a potent treatment of human obesity and type 2 diabetes mellitus, the so-called diabesity characterized by lipotoxicity and insulin resistance. +lncRNA target 31873061 hsa-mir-22 Diabetes Mellitus, Type 2 These original findings suggest that miRNA3p inhibition could become a potent treatment of human obesity and type 2 diabetes mellitus, the so-called diabesity characterized by lipotoxicity and insulin resistance. +lncRNA target 31873061 hsa-mir-22 Hyperlipidemias These original findings suggest that miRNA3p inhibition could become a potent treatment of human obesity and type 2 diabetes mellitus, the so-called diabesity characterized by lipotoxicity and insulin resistance. +lncRNA target 31873061 hsa-mir-22 Diabetes Mellitus These original findings suggest that miRNA3p inhibition could become a potent treatment of human obesity and type 2 diabetes mellitus, the so-called diabesity characterized by lipotoxicity and insulin resistance. +lncRNA target 31873045 hsa-let-7b Melanoma Here, we detected hsa-let-7b expression and its role in melanoma. In conclusion, hsa-let-7b regulates melanoma cells proliferation in vitro by targeting UHRF1. +genetics_overexpression_promote 31872875 hsa-mir-21 Carcinoma, Small Cell Overexpression of miR143HG led to decreased, whereas miR-21 overexpression resulted in increased rate of LSCC cell migration and invasion. +other 31872875 hsa-mir-143 Squamous Cell Carcinoma of Head and Neck OBJECTIVE: This study aimed to investigate the role of lncRNA miR143HG in laryngeal squamous cell carcinoma (LSCC). +genetics_overexpression_promote 31872875 hsa-mir-143 Carcinoma, Small Cell Overexpression of miR143HG led to decreased, whereas miR-21 overexpression resulted in increased rate of LSCC cell migration and invasion. +transcription factor target 31872646 hsa-mir-34a Kidney Diseases In addition,it has been reported that rhein,hyperoside and mycelium of Cordyceps sinensis all can modulate autophagy in renal tubular epithelial cell via regulating the autophagy-related signaling pathways in vivo and in vitro to reduce renal damage and aging,which is likely mediated by the miR-34 a pathway. +other 31872641 hsa-mir-21 Diabetic Angiopathies These results suggested that DJC had therapeutic effects on diabetic macrovascular diseases,and the mechanism of action may be related to the regulation of miRNA-126,miRNA-155,miRNA-146 a and miRNA-21 levels,as well as the reduction of inflammatory factors and vascular inflammatory response. +other 31872641 hsa-mir-126 Diabetic Angiopathies These results suggested that DJC had therapeutic effects on diabetic macrovascular diseases,and the mechanism of action may be related to the regulation of miRNA-126,miRNA-155,miRNA-146 a and miRNA-21 levels,as well as the reduction of inflammatory factors and vascular inflammatory response. +other 31872641 hsa-mir-146 Diabetic Angiopathies These results suggested that DJC had therapeutic effects on diabetic macrovascular diseases,and the mechanism of action may be related to the regulation of miRNA-126,miRNA-155,miRNA-146 a and miRNA-21 levels,as well as the reduction of inflammatory factors and vascular inflammatory response. +other 31872641 hsa-mir-155 Diabetic Angiopathies These results suggested that DJC had therapeutic effects on diabetic macrovascular diseases,and the mechanism of action may be related to the regulation of miRNA-126,miRNA-155,miRNA-146 a and miRNA-21 levels,as well as the reduction of inflammatory factors and vascular inflammatory response. +genetics_knock down_promote 31872565 hsa-mir-16 Uterine Cervical Neoplasms 5p or CARM1 knockdown could inhibit the survival of CC cell and induced apoptosis. +circulation_biomarker_diagnosis_ns 31872468 hsa-mir-663b Urinary Bladder Neoplasms Here, we isolated exosomes from plasma and found that the miR-663b level was elevated in exosomes from plasma of patients with BC compared with healthy controls. +transcription factor target 31872383 hsa-mir-489 Multiple Myeloma CONCLUSIONS: miR-489 inhibited MM tumor growth via LDHA-mediated glycolytic metabolism, suggesting potential therapeutic target ability of miR-489/LDHA for MM. +genetics_knock down_promote 31872255 hsa-mir-497 Osteoporosis 5p are involved in bone metabolism and associated with progressive bone loss of due to osteoporosis, suggesting that circulating miR-181c-5p and miR +genetics_knock down_promote 31872255 hsa-mir-181c Osteoporosis 5p are involved in bone metabolism and associated with progressive bone loss of due to osteoporosis, suggesting that circulating miR-181c-5p and miR +other 31871958 hsa-mir-200 Fibrosis One of the key pathways found was the axis miRTGF-beta, that was significantly altered by EV administration, thereby affecting the EMT signaling and preventing renal inflammatory response and fibrosis development. +other 31871958 hsa-mir-200 Kidney Diseases One of the key pathways found was the axis miRTGF-beta, that was significantly altered by EV administration, thereby affecting the EMT signaling and preventing renal inflammatory response and fibrosis development. +other 31871878 hsa-mir-663a Colonic Neoplasms Among all these hub genes, hsa-miR-23a-3p (OR = 2.6391, p = 6.23 x 10(-5)) and hsa-miR-663a (OR = 1.4220, p = 0.0069) were identified as an independent risk factor of colon cancer by multivariate regression. +other 31871878 hsa-mir-23a Colonic Neoplasms Among all these hub genes, hsa-miR-23a-3p (OR = 2.6391, p = 6.23 x 10(-5)) and hsa-miR-663a (OR = 1.4220, p = 0.0069) were identified as an independent risk factor of colon cancer by multivariate regression. +transcription factor target 31871537 hsa-mir-15b Cardiomyopathies Pterostilbene protected against high fructose-induced myocardial fibrosis through the inhibition of Pitx2c/miR-15b pathway to suppress p-p53-activated TGF-beta1/Smads signaling, warranting the consideration of Pitx2c/miR-15b pathway as a therapeutic target in myocardial fibrosis. +exosome 31871512 hsa-mir-425 Lung Injury Exosomes from ARDS patients delivered less miR-425 into A549 and HFL-1 cells and induced cell apoptosis via upregulating PTEN. +exosome 31871512 hsa-mir-425 Respiratory Distress Syndrome Exosomes from ARDS patients delivered less miR-425 into A549 and HFL-1 cells and induced cell apoptosis via upregulating PTEN. +other 31871210 hsa-mir-335 Liver Cirrhosis We show that let-7, miR-30, miR-29c, miR-335, and miR-338 (collectively termed antifibrotic microRNAs [AF-miRNAs]) down-regulate key structural, signaling, and remodeling components of the extracellular matrix. +other 31871210 hsa-let-7 Liver Cirrhosis We show that let-7, miR-30, miR-29c, miR-335, and miR-338 (collectively termed antifibrotic microRNAs [AF-miRNAs]) down-regulate key structural, signaling, and remodeling components of the extracellular matrix. +other 31871210 hsa-mir-338 Liver Cirrhosis We show that let-7, miR-30, miR-29c, miR-335, and miR-338 (collectively termed antifibrotic microRNAs [AF-miRNAs]) down-regulate key structural, signaling, and remodeling components of the extracellular matrix. +other 31871210 hsa-mir-29c Liver Cirrhosis We show that let-7, miR-30, miR-29c, miR-335, and miR-338 (collectively termed antifibrotic microRNAs [AF-miRNAs]) down-regulate key structural, signaling, and remodeling components of the extracellular matrix. +lncRNA target 31871129 hsa-mir-541 Sjogren's Syndrome Lastly, it was demonstrated that FAM83H-AS1/miR3p/WNT3A ameliorated SpA-mediated inhibition of the osteogenic differentiation of hBMSCs, which provided a novel therapeutic strategy for patients with osteomyelitis. +lncRNA target 31871129 hsa-mir-541 Osteomyelitis Lastly, it was demonstrated that FAM83H-AS1/miR3p/WNT3A ameliorated SpA-mediated inhibition of the osteogenic differentiation of hBMSCs, which provided a novel therapeutic strategy for patients with osteomyelitis. +circulation_biomarker_diagnosis_up 31870893 hsa-mir-340 Stroke 5p), a suppressor of certain target genes in brain, reportedly is decreased in peripheral circulation of acute stroke patients. +other 31870893 hsa-mir-340 Reperfusion Injury This study explores the effect of miR5p on ischemia/reperfusion insults by exposing rat hippocampal neurons to oxygen-glucose deprivation/reoxygenation (OGDR) in vitro. +lncRNA target 31870440 hsa-mir-485 Thyroid Cancer, Papillary 5p/Raf1 axis, which indicated that LINC00460 may be a potential biomarker and therapeutic target for PTC. +circulation_biomarker_diagnosis_ns 31870402 hsa-mir-590 Stomach Neoplasms In return, HOXC-AS1 positively regulated MYC expression in GC through targeting miR3p/MYC axis in cytoplasm and modulating BRG1/beta-catenin complex-activated MYC transcription in nucleus. +genetics_knock down_promote 31870266 hsa-mir-451 Seizures This research investigated the role of miR-451 in seizure and its detailed mechanism. RESULTS: The results showed that miR-451 is up regulated in KA-induced seizure models and miR- 451 knockout decreased the behavior score and improved the pathological changes of the hippocampus. +genetics_knock down_suppress 31870262 hsa-mir-16 Myocardial Infarction 5p knockdown may be a new therapeutic target for myocardial infarction. +other 31870216 hsa-mir-181a Lupus Erythematosus, Systemic Meanwhile, T lymphocytes were collected to assess the expression levels of genes, proteins in relation to SLE and miR-181a by polymerase chain reaction and Western blot. +circulation_biomarker_diagnosis_up 31870103 hsa-mir-29a Leukemia, Myeloid, Acute RESULTS: Our data revealed that the circulating levels of miR-29a-3p and miR-92a-3p exhibited significant reduction in 90% and 100% of AML patients, respectively, when compared to the control group (p<0.001). +circulation_biomarker_diagnosis_up 31870103 hsa-mir-92a Leukemia, Myeloid, Acute RESULTS: Our data revealed that the circulating levels of miR-29a-3p and miR-92a-3p exhibited significant reduction in 90% and 100% of AML patients, respectively, when compared to the control group (p<0.001). +other 31868949 hsa-mir-193a Osteoarthritis In conclusion, NEAT1/miR-193a-3p/SOX5 axis regulates cartilage matrix degradation in human OA. +lncRNA target 31868937 hsa-mir-148b Nerve Degeneration In the current study, we explored the potential function of microRNA-148b-3p (miR-148b-3p) in regulating neuronal injury induced by oxygen-glucose deprivation/reoxygenation (OGD/R) in vitro, a cellular model for mimicking cerebral ischaemia/reperfusion injury. Our study indicates that the miR-148b-3p/Sestrin2/Nrf2 axis plays an important role in regulating neuronal injury and may serve as a potential therapeutic target for providing neuroprotection during cerebral ischaemia/reperfusion injury. +lncRNA target 31868937 hsa-mir-148b Reperfusion Injury In the current study, we explored the potential function of microRNA-148b-3p (miR-148b-3p) in regulating neuronal injury induced by oxygen-glucose deprivation/reoxygenation (OGD/R) in vitro, a cellular model for mimicking cerebral ischaemia/reperfusion injury. Our study indicates that the miR-148b-3p/Sestrin2/Nrf2 axis plays an important role in regulating neuronal injury and may serve as a potential therapeutic target for providing neuroprotection during cerebral ischaemia/reperfusion injury. +other 31868881 hsa-mir-138 Pre-Eclampsia We observed the microRNA, MIR138, to be upregulated in singleton preeclamptic placentas; however, this appears to be a female infant sex-specific effect. +lncRNA target 31868319 hsa-let-7a-1 Glioma METHODS AND RESULTS: Microarray data analysis provided data indicating the involvement of miR cluster MC-let-7a-1 ~ let-7d in glioma via STAT3. +lncRNA target 31868319 hsa-let-7d Glioma METHODS AND RESULTS: Microarray data analysis provided data indicating the involvement of miR cluster MC-let-7a-1 ~ let-7d in glioma via STAT3. +circulation_biomarker_diagnosis_ns 31868204 hsa-mir-221 Cardiomyopathy, Hypertrophic CONCLUSIONS: Circulating miR-221 is consistent with that in myocardial tissue, and correlated with myocardial fibrosis and hypertrophy. +circulation_biomarker_diagnosis_ns 31868204 hsa-mir-221 Diabetic Nephropathies CONCLUSIONS: Circulating miR-221 is consistent with that in myocardial tissue, and correlated with myocardial fibrosis and hypertrophy. +circulation_biomarker_diagnosis_ns 31868204 hsa-mir-221 Cardiomegaly CONCLUSIONS: Circulating miR-221 is consistent with that in myocardial tissue, and correlated with myocardial fibrosis and hypertrophy. +lncRNA target 31868202 hsa-mir-4688 Aortic Aneurysm, Abdominal Conclusively, lncRNA NEAT1 induced by STAT3 was identified as a ceRNA and facilitated AAA formation by targeting miR-4688/TULP3 axis. +lncRNA target 31868085 hsa-mir-140 Carcinoma, Hepatocellular In conclusion, ANCR promoted HCC metastasis by upregulating HNRNPA1, inhibiting HNRNPA1 degradation and sponging miR3p. +genetics_overexpression_promote 31867983 hsa-mir-140 Squamous Cell Carcinoma of Head and Neck Overexpression of miR +exosome 31867895 hsa-mir-20b Diabetes Mellitus A significant upregulation of miR-20b-5p is observed in exosomes isolated from patients with type 2 diabetes mellitus (T2DM), and this miRNA is able to suppress human umbilical vein endothelial cell angiogenesis via regulation of Wnt9b/beta-catenin signaling. Together, these findings thus provide strong evidence that miR-20b-5p is highly enriched in exosomes from patients with T2DM and can be transferred to cells of the vascular endothelium, where it targets Wnt9b signaling to negatively regulate cell functionality and angiogenesis. +exosome 31867895 hsa-mir-20b Wounds and Injuries A significant upregulation of miR-20b-5p is observed in exosomes isolated from patients with type 2 diabetes mellitus (T2DM), and this miRNA is able to suppress human umbilical vein endothelial cell angiogenesis via regulation of Wnt9b/beta-catenin signaling. Together, these findings thus provide strong evidence that miR-20b-5p is highly enriched in exosomes from patients with T2DM and can be transferred to cells of the vascular endothelium, where it targets Wnt9b signaling to negatively regulate cell functionality and angiogenesis. +genetics_GWAS 31867596 hsa-mir-196b Leukemia, Myeloid Here, we show that the lncRNA HOXA10-AS, located antisense to HOXA10 and mir-196b in the HOXA cluster, is highly expressed in hematopoietic stem cells (HSCs) as well as in KMT2A-rearranged and NPM1 mutated acute myeloid leukemias (AMLs). +other 31866945 hsa-mir-197 Obesity Five among them: miR5p, miR125b-5p, miR-125a-5p, miR320a, miR-99b-were upregulated in T2D+ patients with obesity, while only two miRs, miR-23b-3p, and miR197-3p, were increased in T2D- patients with obesity. +other 31866945 hsa-mir-23b Diabetes Mellitus, Type 2 Five among them: miR5p, miR125b-5p, miR-125a-5p, miR320a, miR-99b-were upregulated in T2D+ patients with obesity, while only two miRs, miR-23b-3p, and miR197-3p, were increased in T2D- patients with obesity. +other 31866945 hsa-mir-125b Obesity Five among them: miR5p, miR125b-5p, miR-125a-5p, miR320a, miR-99b-were upregulated in T2D+ patients with obesity, while only two miRs, miR-23b-3p, and miR197-3p, were increased in T2D- patients with obesity. +other 31866945 hsa-mir-125a Diabetes Mellitus, Type 2 Five among them: miR5p, miR125b-5p, miR-125a-5p, miR320a, miR-99b-were upregulated in T2D+ patients with obesity, while only two miRs, miR-23b-3p, and miR197-3p, were increased in T2D- patients with obesity. +other 31866945 hsa-mir-125a Obesity Five among them: miR5p, miR125b-5p, miR-125a-5p, miR320a, miR-99b-were upregulated in T2D+ patients with obesity, while only two miRs, miR-23b-3p, and miR197-3p, were increased in T2D- patients with obesity. +other 31866945 hsa-mir-204 Obesity Five among them: miR5p, miR125b-5p, miR-125a-5p, miR320a, miR-99b-were upregulated in T2D+ patients with obesity, while only two miRs, miR-23b-3p, and miR197-3p, were increased in T2D- patients with obesity. +other 31866945 hsa-mir-125b Diabetes Mellitus, Type 2 Five among them: miR5p, miR125b-5p, miR-125a-5p, miR320a, miR-99b-were upregulated in T2D+ patients with obesity, while only two miRs, miR-23b-3p, and miR197-3p, were increased in T2D- patients with obesity. +other 31866945 hsa-mir-204 Diabetes Mellitus, Type 2 Five among them: miR5p, miR125b-5p, miR-125a-5p, miR320a, miR-99b-were upregulated in T2D+ patients with obesity, while only two miRs, miR-23b-3p, and miR197-3p, were increased in T2D- patients with obesity. +other 31866945 hsa-mir-20a Obesity Five among them: miR5p, miR125b-5p, miR-125a-5p, miR320a, miR-99b-were upregulated in T2D+ patients with obesity, while only two miRs, miR-23b-3p, and miR197-3p, were increased in T2D- patients with obesity. +other 31866945 hsa-mir-20a Diabetes Mellitus, Type 2 Five among them: miR5p, miR125b-5p, miR-125a-5p, miR320a, miR-99b-were upregulated in T2D+ patients with obesity, while only two miRs, miR-23b-3p, and miR197-3p, were increased in T2D- patients with obesity. +other 31866945 hsa-mir-197 Diabetes Mellitus, Type 2 Five among them: miR5p, miR125b-5p, miR-125a-5p, miR320a, miR-99b-were upregulated in T2D+ patients with obesity, while only two miRs, miR-23b-3p, and miR197-3p, were increased in T2D- patients with obesity. +other 31866945 hsa-mir-23b Obesity Five among them: miR5p, miR125b-5p, miR-125a-5p, miR320a, miR-99b-were upregulated in T2D+ patients with obesity, while only two miRs, miR-23b-3p, and miR197-3p, were increased in T2D- patients with obesity. +other 31866771 hsa-mir-21 Depression CONCLUSIONS: The expression of miR-21 and miR-146a are associated with the plaque stability in coronary stenotic lesions, whereas miR-155 expression is inversely associated with the plaque stability. +other 31866771 hsa-mir-146a Depression CONCLUSIONS: The expression of miR-21 and miR-146a are associated with the plaque stability in coronary stenotic lesions, whereas miR-155 expression is inversely associated with the plaque stability. +other 31866771 hsa-mir-155 Depression CONCLUSIONS: The expression of miR-21 and miR-146a are associated with the plaque stability in coronary stenotic lesions, whereas miR-155 expression is inversely associated with the plaque stability. +genetics_overexpression_promote 31866763 hsa-mir-566 Colonic Neoplasms MiR-566 overexpression significantly inhibited PSKH1 expression and reintroduction of PSKH1 partially reversed the effects of miR-566 on CRC cell growth and metastasis in SW480 and Caco-2 cells. +genetics_overexpression_promote 31866584 hsa-mir-129 Osteosarcoma In addition, overexpression of HIF1A-AS2 promoted cell proliferation, cell cycle progression and invasion of osteosarcoma cells through the modulation of miR +genetics_overexpression_promote 31866582 hsa-mir-149 Colonic Neoplasms Taken together, overexpression of METTL1 sensitized CR-CC cells to cisplatin by modulating miR +genetics_GWAS 31866580 hsa-mir-205 Diabetic Foot Recently, genetically modified MSCs have been used in therapy and we have shown that depletion of micoRNA +genetics_knock down_promote 31866421 hsa-mir-21 Esophageal Squamous Cell Carcinoma RESULTS: We found underexpressed GAS5 and RECK, and overexpressed miR-21 in ESCC. +lncRNA target 31865425 hsa-mir-21 Dmd-Associated Dilated Cardiomyopathy Our results suggested that GAS5/miR5p axis may serve as a candidate therapeutic target for DCM. +virus_miRNA 31865380 hbv-mir-3 Acute Liver Injury HBV-miR-3 activates the innate immune response to restrain HBV replication by multiple pathways, which may suppress HBV-induced acute liver cell injury and affect the progression of persistent HBV infection. +lncRNA target 31865363 hsa-mir-1972 Ovarian Neoplasms Additionally, LINC01125 participated in the apoptosis pathway by directly binding to miR-1972 in OC cells. CONCLUSIONS Therefore, we suggest that LINC01125 might act as a tumor suppressor in OC and enhances the cisplatin sensitivity of OC cells by binding to miR-1972. +transcription factor target 31864714 hsa-mir-593 Carcinoma, Non-Small-Cell Lung 5p inhibits NSCLC cell proliferation by inhibiting PLK1 expression. +other 31864625 hsa-mir-221 Colorectal Neoplasms The strategy was applied to the detection of a colorectal cancer marker, miR-221, by using a stable Zr(IV)-MOF, UiONH(2). +other 31864341 hsa-mir-101 Colorectal Neoplasms Moreover, miR3p also downregulated IL6ST, STAT3A/B, and MYC mRNA levels, genes associated with stemness properties of CRC cells. +other 31864304 hsa-mir-223 Renal Insufficiency, Chronic In order to assess molecular mechanisms underlying this association, we examined whether cardiovascular disease (CVD)-associated miRNAs (miR-126, miR-197, and miR-223) were associated with CKD among Japanese elderly survivors after an earthquake. +other 31864304 hsa-mir-126 Renal Insufficiency, Chronic In order to assess molecular mechanisms underlying this association, we examined whether cardiovascular disease (CVD)-associated miRNAs (miR-126, miR-197, and miR-223) were associated with CKD among Japanese elderly survivors after an earthquake. +other 31864304 hsa-mir-197 Renal Insufficiency, Chronic In order to assess molecular mechanisms underlying this association, we examined whether cardiovascular disease (CVD)-associated miRNAs (miR-126, miR-197, and miR-223) were associated with CKD among Japanese elderly survivors after an earthquake. +lncRNA target 31864213 hsa-mir-142 Uterine Cervical Neoplasms Our previous results showed that metformin can destroy the sponge effect of long-chain non-coding RNA MALAT1/miR3p and inhibit the proliferation of cervical cancer cells. +other 31863884 hsa-mir-142 Neuroblastoma CONCLUSIONS: miR3p-mediated down-regulation of FBXO3 may be a potential agent for protection against cerebral I/R injury. +genetics_knock down_promote 31863778 hsa-mir-30 Colorectal Neoplasms 3p inhibitors could promote the proliferation, migration and invasion and block apoptosis of CRC cells, whereas knockdown of HLA-F-AS1 or transfection of miR +other 31863774 hsa-mir-29b Breast Neoplasms Functionally and mechanistically, circACAP2 promoted breast cancer proliferation and motility by sponging miR-29a/b-3p and modulating COL5A1. CircACAP2-miR-29a/b-3p-COL5A1 axis leads to breast cancer tumorigenesis and could hopefully be a novel method for diagnosis and treatment for breast cancer. +other 31863774 hsa-mir-29a Breast Neoplasms Functionally and mechanistically, circACAP2 promoted breast cancer proliferation and motility by sponging miR-29a/b-3p and modulating COL5A1. CircACAP2-miR-29a/b-3p-COL5A1 axis leads to breast cancer tumorigenesis and could hopefully be a novel method for diagnosis and treatment for breast cancer. +transcription factor target 31863773 hsa-mir-92a Endometriosis Hence, this study revealed that miR-92a contributed to the development of progesterone resistant endometriosis by suppression of PTEN expression, and modulation of miR-92a might be a potential medical method of treating endometriosis. +transcription factor target 31863770 hsa-mir-146b Fatty Liver LF, CR, Que and Ex significantly ameliorated HF-induced hepatic steatosis to varying degrees, inhibited T4 production via differentially elevating miR-339, miR-383 and miR-146b to decrease NIS expression and regulating miR-200a/Nrf2 to maintain redox status in the thyroid. +transcription factor target 31863770 hsa-mir-339 Obesity LF, CR, Que and Ex significantly ameliorated HF-induced hepatic steatosis to varying degrees, inhibited T4 production via differentially elevating miR-339, miR-383 and miR-146b to decrease NIS expression and regulating miR-200a/Nrf2 to maintain redox status in the thyroid. +transcription factor target 31863770 hsa-mir-200a Obesity LF, CR, Que and Ex significantly ameliorated HF-induced hepatic steatosis to varying degrees, inhibited T4 production via differentially elevating miR-339, miR-383 and miR-146b to decrease NIS expression and regulating miR-200a/Nrf2 to maintain redox status in the thyroid. +transcription factor target 31863770 hsa-mir-146b Obesity LF, CR, Que and Ex significantly ameliorated HF-induced hepatic steatosis to varying degrees, inhibited T4 production via differentially elevating miR-339, miR-383 and miR-146b to decrease NIS expression and regulating miR-200a/Nrf2 to maintain redox status in the thyroid. +transcription factor target 31863770 hsa-mir-200a Fatty Liver LF, CR, Que and Ex significantly ameliorated HF-induced hepatic steatosis to varying degrees, inhibited T4 production via differentially elevating miR-339, miR-383 and miR-146b to decrease NIS expression and regulating miR-200a/Nrf2 to maintain redox status in the thyroid. +transcription factor target 31863770 hsa-mir-339 Fatty Liver LF, CR, Que and Ex significantly ameliorated HF-induced hepatic steatosis to varying degrees, inhibited T4 production via differentially elevating miR-339, miR-383 and miR-146b to decrease NIS expression and regulating miR-200a/Nrf2 to maintain redox status in the thyroid. +transcription factor target 31863770 hsa-mir-383 Fatty Liver LF, CR, Que and Ex significantly ameliorated HF-induced hepatic steatosis to varying degrees, inhibited T4 production via differentially elevating miR-339, miR-383 and miR-146b to decrease NIS expression and regulating miR-200a/Nrf2 to maintain redox status in the thyroid. +transcription factor target 31863770 hsa-mir-383 Obesity LF, CR, Que and Ex significantly ameliorated HF-induced hepatic steatosis to varying degrees, inhibited T4 production via differentially elevating miR-339, miR-383 and miR-146b to decrease NIS expression and regulating miR-200a/Nrf2 to maintain redox status in the thyroid. +transcription factor target 31863665 hsa-mir-412 Carcinoma, Renal Cell Furthermore, the miRNAs-target gene regulation analyses showed that miR-412 and miR-199b respectively targeted IRF7 and PPARGC1A to regulate the immune response in ccRCC. +transcription factor target 31863665 hsa-mir-199b Carcinoma, Renal Cell Furthermore, the miRNAs-target gene regulation analyses showed that miR-412 and miR-199b respectively targeted IRF7 and PPARGC1A to regulate the immune response in ccRCC. +lncRNA target 31863664 hsa-mir-202 Carcinoma, Non-Small-Cell Lung Next, we verified that MALAT1 could act as a competing endogenous RNA (ceRNA) by sponging miR-202 in NSCLC and there is a negative correlation between MALAT1 and miR-202. CONCLUSION: This study demonstrated that lncRNA-MALAT1 gets involved in NSCLC progression by targeting miR-202, indicating that MALAT1 may serve as a novel therapeutic target for NSCLC treatment. +other 31863632 hsa-mir-205 Retinal Diseases Hence, miR5p is proposed as a candidate against eye-related proliferative diseases. +lncRNA target 31863364 hsa-mir-21 Glomerulonephritis, IGA CONCLUSIONS: Our results suggested that in IgAN, the upregulated miR-21 expression in T lymphocytes inhibited SPRY1 expression and thereby induced Th17 polarization, which might influence the characteristic feature of IgA1 overproduction in IgAN patients. +transcription factor target 31863330 hsa-mir-143 Urinary Bladder Neoplasms A comprehensive overview of miR-143 targets and pathways implicated in BCa initiation, diagnosis or prognosis using bioinformatical analysis, was conducted. +lncRNA target 31862871 hsa-mir-195 Tuberculosis 5p/ETV1 axis was critical in the regulation of BTB permeability and provided new targets for the treatment of glioma. +lncRNA target 31862871 hsa-mir-195 high grade glioma 5p/ETV1 axis was critical in the regulation of BTB permeability and provided new targets for the treatment of glioma. +lncRNA target 31862871 hsa-mir-195 Drug Hypersensitivity The present study showed that the combined application of PTBP1, circRNA_001160, and miR5p with the anti-tumor drug Dox effectively promoted Dox through BTB and extremely induced the apoptosis of glioma cells. +lncRNA target 31862869 hsa-mir-199b Parkinson Disease CONCLUSIONS Curcumin attenuated neuroinflammation induced by LPS through regulating miR-199b-5p/IKKss/NF-kappaB axis in microglia. +genetics_knock down_suppress 31862778 hsa-mir-223 Breast Neoplasms SIGNIFICANCE: miR-223 may represent a predictive biomarker of response to CDK4/6 inhibitors and its loss could identify DCIS lesions that are likely to progress into invasive breast cancer. +lncRNA target 31862507 hsa-mir-181c Migraine Disorders In this study, we employed an in vitro model, and found that MA treatment could inhibit the expression of miR-181c, which directly targets and regulates TNF-alpha, and ultimately induces apoptosis and damages the intestinal barrier. To the best of our knowledge, this is the first report evidencing that miR-181c is involved in MA-induced intestinal barrier injury via TNF-alpha regulation, which introduces novel potential therapeutic targets for MA-dependent intestinal diseases. +lncRNA target 31862507 hsa-mir-181c Intestinal Diseases To the best of our knowledge, this is the first report evidencing that miR-181c is involved in MA-induced intestinal barrier injury via TNF-alpha regulation, which introduces novel potential therapeutic targets for MA-dependent intestinal diseases. +lncRNA target 31862399 hsa-mir-21 Hyperglycemia Collectively, these findings indicate that hyperglycemia and associated AGE suppress RECK expression via oxidative stress/TRAF3IP2/NF-B and p38 MAPK/miR-21 induction. +lncRNA target 31861929 hsa-mir-204 Aortic Valve Disease We sought to analyze miR-204 expression in diseased human aortic valves and determine the role of this miR in AVIC osteogenic activity associated with CAVD pathobiology. Exogenous miR-204 may have therapeutic potential for inhibiting valvular calcification associated with CAVD progression. +genetics_knock down_promote 31861621 hsa-mir-155 West Nile Fever Besides, overexpression of miR-155 in human neuronal cells modulated anti-viral cytokine response and resulted in significantly lower WNV replication. +genetics_knock down_promote 31861450 hsa-mir-26a Hyperlipoproteinemia Type II In this study, we found that the expression levels of miR-26a were significantly upregulated upon FHV-1 infection. Furthermore, FHV-1 infection induced the expression of miR-26a via a cGAS-dependent pathway, and knockdown of cellular cGAS significantly blocked the expression of miR-26a induced by poly (dA:dT) or FHV-1 infection. +transcription factor target 31861383 hsa-mir-142 Esophageal Neoplasms Preclinical tests showed that suppression of SREBP1 using fatostatin led to the reduced malignant phenotype of esophageal cancer via the reduction of EMT markers and increased tumor suppressor, miR +lncRNA target 31860169 hsa-mir-96 Adenocarcinoma of Lung 5p/CYLD network based on ceRNA mechanism plays an important role in the development of LUAD and provides a new direction and theoretical basis for targeted therapy of LUAD. +genetics_overexpression_suppress 31859543 hsa-mir-613 Colorectal Neoplasms WNT3 and VEGFA overexpression resulted in partial rescue of miR +genetics_knock down_promote 31859457 hsa-mir-613 Nasopharyngeal Carcinoma Gain- and loss-of-function studies further confirmed that CYTOR induced the upregulation of ANXA2 by competitively binding to miR-613, thus leading to NPC metastasis. +lncRNA target 31859425 hsa-mir-499 Stomach Neoplasms 5p-PDCD4 signaling axis plays an important role in gastric cancer progression and a potentially therapeutic target for gastric cancer treatment. +lncRNA target 31858855 hsa-mir-155 Brain Ischemia Whether resveratrol can promote the M2 polarization of microglia and further inhibit neuroinflammation after cerebral ischemia, and its correlation with miR-155 is unclear. Resveratrol promoted the M2 polarization of microglia and reduced neuroinflammation in injured brain and activated BV2 microglia.Conclusions: In conclusion, this research indicated that resveratrol promoted the M2 polarization of microglia and reduced neuroinflammation after cerebral ischemia by inhibiting miR-155. +genetics_knock down_promote 31858815 hsa-mir-24 Gallbladder Neoplasms 5p overexpression on GBC cell metastatic phenotypes. +lncRNA target 31858580 hsa-mir-26a Carcinoma, Hepatocellular CONCLUSIONS: LncRNA HCG11 accelerated the proliferation, metastasis, and autophagy while impeded the apoptosis of HCC cells via HCG11/miR-26a-5p/ATG12 axis. +circulation_biomarker_diagnosis_ns 31858576 hsa-mir-375 Osteoporosis RESULTS: MiR-375 remained at a high level in serum of OP patients, while gradually decreased with the prolongation of osteogenic differentiation in isolated hMSCs. +lncRNA target 31858564 hsa-mir-133 Diabetic Nephropathies The silence of miR-133 inhibits kidney injury in DN via the MAPK/ERK signaling pathway. +transcription factor target 31858563 hsa-mir-205 Kidney Diseases CONCLUSIONS: MiR-205 agonist can improve the pathological morphology in the sepsis rats with renal injury, improve renal cell apoptosis, and inhibit the protein levels of HMGB1 and PTEN in renal tissues. MiR-205 alleviates sepsis-induced renal injury through the HMGB1-PTEN signaling pathway. +transcription factor target 31858563 hsa-mir-205 Sepsis CONCLUSIONS: MiR-205 agonist can improve the pathological morphology in the sepsis rats with renal injury, improve renal cell apoptosis, and inhibit the protein levels of HMGB1 and PTEN in renal tissues. MiR-205 alleviates sepsis-induced renal injury through the HMGB1-PTEN signaling pathway. +lncRNA target 31858562 hsa-mir-29a Sepsis The normal rat kidney epithelial (NRK-52E) cell line was cultured in vitro, and the model was established in vitro via LPS to study the influences of lncRNA-MIAT and miR-29a on the kidney injury in sepsis rats. +lncRNA target 31858562 hsa-mir-29a Diabetic Nephropathies The normal rat kidney epithelial (NRK-52E) cell line was cultured in vitro, and the model was established in vitro via LPS to study the influences of lncRNA-MIAT and miR-29a on the kidney injury in sepsis rats. +circRNA target 31858560 hsa-mir-625 Melanoma CONCLUSIONS: Circ0016418 regulated proliferation, migration, invasion, and EMT of skin melanoma cells through miR-625/YY1 axis. +lncRNA target 31858559 hsa-mir-187 Glioma Furthermore, SMAD1 was identified as a direct target for miR-187 in glioma, which could be repressed by miR-187. +genetics_overexpression_promote 31858558 hsa-mir-491 Glioma CONCLUSIONS: MiR-491 overexpression inhibited the proliferation through the Wnt3a/beta-catenin pathway and invasion-mediated EMT in glioma. +genetics_knock down_suppress 31858557 hsa-mir-520b Glioma Moreover, circ-TTBK2 exerted its roles via miR-520b/EZH2 axis in glioma cells, and the knockdown of circ-TTBK2 could hinder the progression of glioma. +genetics_knock down_suppress 31858557 hsa-mir-520 Glioma Moreover, circ-TTBK2 exerted its roles via miR-520b/EZH2 axis in glioma cells, and the knockdown of circ-TTBK2 could hinder the progression of glioma. +genetics_overexpression_promote 31858556 hsa-mir-628 Glioblastoma CONCLUSIONS: Overexpression of circ-00018 01 accelerates cell proliferation, migration, invasion and EMT in GBM by absorbing miR +circRNA target 31858554 hsa-mir-1304 Thyroid Neoplasms CONCLUSIONS: Circ_0067934 downregulation expedited apoptosis and retarded proliferation, migration, and invasion of TC cells through miR-1304/CXCR1 axis. +lncRNA target 31858553 hsa-mir-1281 Breast Neoplasms Besides, GIHCG might promote the malignant progression of BCa by inhibiting microRNA-1281. +genetics_overexpression_promote 31858545 hsa-mir-106a Stomach Neoplasms CONCLUSIONS: OPI5-AS1 overexpression promotes tumorigenesis and development of GC by sponging miR-106a-5p. +genetics_knock down_suppress 31858542 hsa-mir-212 Colorectal Neoplasms In addition, low expression of miR-212 or overexpression of SOX4 was associated with poor prognosis of colorectal cancer patients. +genetics_overexpression_suppress 31858541 hsa-mir-214 Colorectal Neoplasms Moreover, overexpression of miR +lncRNA target 31858540 hsa-mir-383 Pancreatic Carcinoma Our results show that miR-383 can act directly on GAB1 to inhibit its expression in PC. +lncRNA target 31858539 hsa-mir-541 Carcinoma, Hepatocellular 3p suppressed the invasion and migration of HCC cells by directly targeting and inhibiting TMPRSS4 protein expression. +lncRNA target 31858538 hsa-mir-212 Carcinoma, Renal Cell 5p acted as a tumor suppressor gene in ccRCC. +transcription factor target 31858533 hsa-mir-195 Uterine Cervical Neoplasms 5p inhibited cell migration and invasion in CC by suppressing ARL2 expression. +genetics_knock down_promote 31858530 hsa-mir-197 Osteosarcoma However, KLF10 was significantly up-regulated after the knockdown of miR +genetics_overexpression_suppress 31858529 hsa-mir-25 Spinal Cord Injuries BBB scale showed elevated locomotor function recovery in SCI rats overexpressing miR +genetics_overexpression_promote 31858527 hsa-mir-127 Spinal Cord Injuries Overexpression of MAPK1 abolished the protective effect of miRNA +circulation_biomarker_diagnosis_ns 31858525 hsa-mir-133 Pre-Eclampsia RESULTS: In vivo experiments demonstrated that the urinary protein content, miR-133 level, systolic blood pressure, diastolic blood pressure, and liver function and renal function indexes were significantly elevated in pre-eclampsia (PE) patients in comparison with normal subjects (p<0.05). +circulation_biomarker_diagnosis_ns 31858525 hsa-mir-133 Pneumonia, Mycoplasma RESULTS: In vivo experiments demonstrated that the urinary protein content, miR-133 level, systolic blood pressure, diastolic blood pressure, and liver function and renal function indexes were significantly elevated in pre-eclampsia (PE) patients in comparison with normal subjects (p<0.05). +exosome 31858380 hsa-mir-125b Myocardial Reperfusion Injury BMSC-derived exosomes carrying miR-125b protected against myocardial I/R by targeting SIRT7. +other 31858324 hsa-mir-490 Carcinoma, Hepatocellular In addition, our results showed that RP11-81H3.2 binds to and regulate miR3p expression in the HCC cells. +other 31857992 hsa-mir-200 Pulmonary Fibrosis The microRNA miR-200 family is downregulated in IPF, but its effect on human IPF ATII cells remains unproven. We wanted to 1) evaluate the characteristics and transdifferentiating ability of IPF ATII cells, and 2) test whether miR-200 family members can rescue the regenerative potential of fibrotic ATII cells. +other 31857645 hsa-mir-4683 Dengue Moreover, hsa_circ_0015962 binds to miR-4683, and hsa_circ_0006459 binds to miR-133b.Downregulation of hsa_circ_0006459 and upregulation of hsa_circ_0015962 affect the treatment response of DF and are potential biomarkers in DF patients. +other 31857645 hsa-mir-133b Dengue Moreover, hsa_circ_0015962 binds to miR-4683, and hsa_circ_0006459 binds to miR-133b.Downregulation of hsa_circ_0006459 and upregulation of hsa_circ_0015962 affect the treatment response of DF and are potential biomarkers in DF patients. +circRNA target 31857500 hsa-mir-421 Triple Negative Breast Neoplasms CONCLUSIONS: In conclusion, CircAHNAK1 inhibits proliferation and metastasis of TNBC by modulating miR-421 and RASA1. Finally, we focused on the regulation of circAHNAK1 on miR-421 and its targeted gene RASA1 in TNBC. +genetics_knock down_promote 31857259 hsa-mir-126 Fractures, Bone Furthermore, utilizing a series in vitro and in vivo gain and loss of function experiments, we confirmed a functional role for exosomal miR-126 in the process of bone fracture healing. +circulation_biomarker_diagnosis_down 31857133 hsa-mir-193a Alzheimer Disease Remarkable positive association was detected between serum miR-193a-3p level and MMSE score in AD patients (r = 0.5889, P < 0.0001). +other 31857113 hsa-mir-363 Endometrial Neoplasms Collectively, these findings indicated that lnc003875/miR-363/EGR1/Ang-1 in CAFs may be crucial for the angiogenesis of PSTT. +other 31857113 hsa-mir-363 Trophoblastic Tumor, Placental Site Collectively, these findings indicated that lnc003875/miR-363/EGR1/Ang-1 in CAFs may be crucial for the angiogenesis of PSTT. +lncRNA target 31857112 hsa-mir-29a Carcinoma, Hepatocellular In conclusion, our findings revealed the crucial role of the miR-29a in liver T-ICs expansion and sorafenib response, rendering miR-29a as an optimal target for the prevention and intervention of HCC. +transcription factor target 31856857 hsa-mir-937 Colonic Neoplasms CONCLUSIONS: These results suggested that miR-937 may act as a prognostic biomarker and a potential target for therapeutic strategy, as well as promote proliferation, migration, and invasion of colon cancer. +other 31856412 hsa-mir-21 Esophageal Squamous Cell Carcinoma The panel consisting of three TAAbs (HCCR, C-myc, and MDM2) and three miRNAs (miR-21, miR-223, and miR-375) attained great diagnostic value for ESCC, with an area under the receiver operating characteristic curve (AUC) of 0.89 (95% CI: 0.85-0.93) with the sensitivity of 69%, the specificity of 90%, the PPV of 83%, the NPV of 79%, and the coincidence rate of 81%. +other 31856412 hsa-mir-223 Esophageal Squamous Cell Carcinoma The panel consisting of three TAAbs (HCCR, C-myc, and MDM2) and three miRNAs (miR-21, miR-223, and miR-375) attained great diagnostic value for ESCC, with an area under the receiver operating characteristic curve (AUC) of 0.89 (95% CI: 0.85-0.93) with the sensitivity of 69%, the specificity of 90%, the PPV of 83%, the NPV of 79%, and the coincidence rate of 81%. +lncRNA target 31856394 hsa-mir-524 Glioblastoma This study demonstrates that a LINC00511/miR5p/YB1/ZEB1 positive feedback loop provides potential therapeutic targets for GBM progression. +circulation_biomarker_diagnosis_up 31856390 hsa-mir-20a Nasopharyngeal Carcinoma 5p in plasma for NPC diagnosis after four-stage validation. +circulation_biomarker_diagnosis_up 31856390 hsa-mir-144 Nasopharyngeal Carcinoma 5p in plasma for NPC diagnosis after four-stage validation. +circulation_biomarker_diagnosis_up 31856390 hsa-mir-17 Nasopharyngeal Carcinoma 5p in plasma for NPC diagnosis after four-stage validation. +circulation_biomarker_diagnosis_up 31856390 hsa-mir-140 Nasopharyngeal Carcinoma 5p in plasma for NPC diagnosis after four-stage validation. +circulation_biomarker_diagnosis_up 31856390 hsa-mir-205 Nasopharyngeal Carcinoma 5p in plasma for NPC diagnosis after four-stage validation. +circulation_biomarker_diagnosis_up 31856390 hsa-let-7b Nasopharyngeal Carcinoma 5p in plasma for NPC diagnosis after four-stage validation. +lncRNA target 31855836 hsa-mir-7 Myotonic Disorders Collectively, these results highlight an unknown function for miR-7 in muscle dysfunction through autophagy- and atrophy-related pathways and support that restoration of miR-7 levels is a candidate therapeutic target for counteracting muscle dysfunction in DM1. +lncRNA target 31855835 hsa-let-7 Carcinoma, Non-Small-Cell Lung We identified functional let-7b hmiRNAs targeting the HMGA2 mRNA, one of the let-7 target genes upregulated in NSCLC, and show that direct uptake in HCC827 cells induced potent and specific gene silencing in vitro and in vivo. +lncRNA target 31855835 hsa-let-7b Carcinoma, Non-Small-Cell Lung We identified functional let-7b hmiRNAs targeting the HMGA2 mRNA, one of the let-7 target genes upregulated in NSCLC, and show that direct uptake in HCC827 cells induced potent and specific gene silencing in vitro and in vivo. +other 31855458 hsa-mir-199a Schizophrenia 5p and hsa-miR-199a-3p) as a signature that mostly related to SZ. +other 31855458 hsa-mir-373 Schizophrenia 5p and hsa-miR-199a-3p) as a signature that mostly related to SZ. +transcription factor target 31855318 hsa-mir-149 Carcinoma, Non-Small-Cell Lung Therefore, these results suggest that UA could attenuate the stemness and chemoresistance of NSCLC cells through targeting miR5p/MyD88 axis. +other 31854959 hsa-mir-142 Colonic Neoplasms 5p and Tiam-1 may be potential diagnostic markers for colon cancer. +genetics_knock down_promote 31854468 hsa-mir-1271 Colorectal Neoplasms Our results showed that knockdown of HCG18 markedly upregulated miR-1271 expression in colorectal cancer cells. +genetics_overexpression_promote 31854049 hsa-mir-1285 Breast Neoplasms Overexpression of miR +lncRNA target 31853782 hsa-mir-186 Esophageal Squamous Cell Carcinoma CONCLUSIONS: Downregulation of SNHG6 inhibited the proliferation, migration, and invasion of ESCC cells through regulating miR +transcription factor target 31853766 hsa-mir-144 Hypertension Our results showed an increase in the expression of miR-33a and miR-144 and an inverse correlation in their target ABCA1 and ABCG1; it may be associated with essential arterial hypertension in patients with cIMT and as consequence for atheromatous plaque. +transcription factor target 31853766 hsa-mir-33a Hypertension Our results showed an increase in the expression of miR-33a and miR-144 and an inverse correlation in their target ABCA1 and ABCG1; it may be associated with essential arterial hypertension in patients with cIMT and as consequence for atheromatous plaque. +genetics_overexpression_promote 31853324 hsa-mir-138 Uterine Cervical Neoplasms Overexpression of miR-138 suppressed cervical cancer cell proliferation, invasion, increased apoptosis and enhanced chemotherapy sensitivity in vivo and in vitro. +other 31853323 hsa-mir-181a Stomach Neoplasms Overall, the CR749391/miR-181a regulatory interaction and association between CR749391 and KLF6 may enhance the current understanding of GC pathogenesis, although CR749391 association with GC prognosis needs further study. +lncRNA target 31853322 hsa-mir-9 Depression Effects of micro ribonucleic acid (miR)-9 on neuronal apoptosis and expression levels of apoptosis genes B-cell lymphoma-2 (Bcl-2) and Bcl-2 associated X protein (Bax) in depression model rats, as well as its regulatory mechanism, were investigated. In conclusion, miR-9 inhibitor can promote the neurological function recovery and inhibit the neuronal apoptosis of depression model rats through activating the Notch signaling pathway, suggesting that miR-9 can be an important therapeutic target for depression. +genetics_overexpression_promote 31853317 hsa-mir-532 Breast Neoplasms Overexpression of miR +transcription factor target 31853314 hsa-mir-1 Triple Negative Breast Neoplasms In conclusion, the present preclinical results indicated that targeting miR +transcription factor target 31853309 hsa-mir-770 Colorectal Adenocarcinoma These results suggest that miR5p may be involved in the regulation of colon cancer resistance to MTX by regulating the expression of the target gene HIPK1. +lncRNA target 31853302 hsa-mir-629 Stomach Neoplasms The current study therefore assessed the impact of miR-629 and FOXO3 on gastric cancer. The results demonstrated that miR-629 and FOXO3 serve vital roles in the development of gastric cancer and may be a future therapeutic target. +lncRNA target 31853295 hsa-mir-144 Arthritis, Rheumatoid 5p may serve as a novel therapeutic target for the treatment of RA. +genetics_knock down_promote 31853275 hsa-mir-190b Colorectal Neoplasms Rescue experiments showed that knockdown of FOXP2 reversed the inhibitory effects of miR-190b inhibitor on the behavior of the CRC cell lines. +transcription factor target 31853229 hsa-mir-4319 Carcinoma, Hepatocellular Through a series of functional experiments, we illustrated that miR-4319 repressed cell proliferation, accelerated apoptosis, inhibited epithelial-mesenchymal transition (EMT) and prevented cancer stemness in HCC cells by targeting FOXQ1 (Forkhead box Q1). +exosome 31853228 hsa-mir-155 Enterovirus Infections Collectively, our findings provide evidence that exosomal miR-155 plays a role in host-pathogen interactions by mediating EV-A71 infection via the repression of PICALM; these results provide insights into the regulatory mechanisms of viral infection. +genetics_knock down_promote 31853188 hsa-mir-937 Breast Neoplasms Double knockdown of CCRL2 and miR +lncRNA target 31853187 hsa-mir-107 Stomach Neoplasms CONCLUSION: PCAT18 inhibits the progression of GC via miR-107/PTEN/PI3K/AKT signaling pathway. +lncRNA target 31853185 hsa-mir-449a Carcinoma, Hepatocellular CONCLUSION: miR-449a is short-term recurrence-related miRNA and inhibits the invasion and metastasis ability of HCC cells by regulating EMT via Notch pathway. +lncRNA target 31853184 hsa-mir-124 Osteosarcoma Interference of HOXA-AS2 attenuated U2OS xenograft tumor growth via upregulating miR +circulation_biomarker_diagnosis_ns 31853096 hsa-mir-126 Renal Insufficiency, Chronic 3p with circadian blood pressure (BP) pattern in CKD patients. +transcription factor target 31852997 hsa-mir-503 Diabetes, Gestational 1-3p (p < 0.05), corresponding to decreased target genes expression for ABCA1, PAK4, and INSR. +transcription factor target 31852997 hsa-mir-199 Obesity, Maternal 1-3p (p < 0.05), corresponding to decreased target genes expression for ABCA1, PAK4, and INSR. +transcription factor target 31852997 hsa-mir-885 Obesity, Maternal 1-3p (p < 0.05), corresponding to decreased target genes expression for ABCA1, PAK4, and INSR. +transcription factor target 31852997 hsa-mir-503 Obesity, Maternal 1-3p (p < 0.05), corresponding to decreased target genes expression for ABCA1, PAK4, and INSR. +transcription factor target 31852997 hsa-mir-199 Diabetes, Gestational 1-3p (p < 0.05), corresponding to decreased target genes expression for ABCA1, PAK4, and INSR. +transcription factor target 31852997 hsa-mir-885 Diabetes, Gestational 1-3p (p < 0.05), corresponding to decreased target genes expression for ABCA1, PAK4, and INSR. +transcription factor target 31852800 hsa-mir-218 Amyotrophic Lateral Sclerosis However, miR-218 relevance to human motor neuron disease was not yet explored. Therefore, miR-218 activity in motor neurons may be susceptible to failure in human ALS, suggesting that miR-218 may be a potential therapeutic target in motor neuron disease. +circulation_biomarker_diagnosis_ns 31852749 hsa-mir-34a Ischemic Stroke We investigate the pattern of miRNA-133b and miRNA-34a expression in patients with ischemic stroke included in a multicenter randomized controlled phase IIb trial (http://www.clinicaltrials.gov; unique identifier: NCT02178657). Intra-arterial BM-MNC transplantation in patients with ischemic stroke seems to modulate early circulating miRNA-34a levels, which have been related to precursor cell migration in stroke and smaller infarct volumes. +genetics_overexpression_promote 31852516 hsa-mir-145 Erectile Dysfunction overexpressing BMSCs may provide a promising novel avenue for age-associated ED therapy. +other 31852504 hsa-mir-141 Pancreatic Carcinoma CONCLUSIONS: We comprehensively reveal the oncogenic role of IGF2BP2 in pancreatic cancer carcinogenesis and confirm that genomic amplification and the silencing of miR-141 contribute to its activation. +other 31852430 hsa-mir-7695 Blast Crisis These findings provides a basis to better understand regulatory mechanisms involved in rice immunity in which miR7695 participates which has a great potential for the development of strategies to improve blast resistance in rice. +other 31852252 hsa-mir-155 Corneal Injuries 5p significantly promoted the repair of corneal epithelial injury and reduced the permeability of the corneal epithelium. +transcription factor target 31852219 hsa-mir-144 Atherosclerosis CONCLUSIONS: Our data demonstrate silencing miR-144 has sex-specific effects and that treatment with antisense oligonucleotides to target miR-144 might result in enhancements in reverse cholesterol transport and oxysterol metabolism in patients with cardiovascular disease. +circulation_biomarker_diagnosis_ns 31852218 hsa-mir-338 Venous Thrombosis 5p level was decreased substantially in peripheral blood mononuclear cells of patients with DVT, and there was significant negative correlation between miR +circulation_biomarker_diagnosis_down 31852062 hsa-mir-135a Carcinoma, Non-Small-Cell Lung ROC curve showed serum miR-135a level could discriminate NSCLC patients from healthy controls (P < .0001) with a corresponding cutoff value of 0.665, and a sensitivity and specificity of 81.3% and 83.1%, respectively. +other 31851864 hsa-mir-642b Obesity The percentage of variation in childhood obesity risk explained by hsa-miR-642b-3p and age was 19%. +lncRNA target 31851859 hsa-mir-5100 Squamous Cell Carcinoma of Head and Neck The invasion and migration abilities of OSCC cells were reduced after treatment with miR-5100 inhibitor, whereas SCAI silencing suppressed the effects of miR-5100 inhibitor on OSCC cell behaviors. +transcription factor target 31851829 hsa-mir-155 Polycystic Ovary Syndrome To sum up, miR-155 promoted proliferation, migration, invasion and the activation of PI3K/AKT and JNK pathways in KGN cells through negatively regulating PDCD4. +genetics_overexpression_promote 31851778 hsa-mir-892b Nasopharyngeal Carcinoma The proliferation, migration and invasion of NPC cells could be largely enhanced by the downregulation of miR-892b as well as the up-regulation of ZFAS1 and LPAR1, while the overexpression of miR-892b and the downregulation of ZFAS1 and LPAR1 decreased these abilities. +other 31851750 hsa-mir-181a Leukemia, Myeloid, Acute The outcomes will be reviewed for association between miR-181a level and AML progression and the strength of this relationship with AML will be investigated. +lncRNA target 31850945 hsa-mir-361 Stomach Neoplasms 5p suppressed gastric carcinoma cell proliferation in vitro, inhibited tumor growth in vivo, and induced gastric carcinoma cell apoptosis. +circulation_biomarker_diagnosis_up 31850721 hsa-mir-185 Diabetes, Gestational CONCLUSIONS: The down-regulation of miR-185 expression in serum and placenta of pregnant women with GDM is negatively correlated with HOMA-IR, suggesting that the decrease of miR-185 may play an important role in the occurrence and development of GDM. +transcription factor target 31850710 hsa-mir-218 Non-alcoholic Fatty Liver Disease Although H2O2 and ATP levels were increased and decreased in NASH models, respectively, antagonizing miR-218 could significantly alleviate those changes. +circulation_biomarker_diagnosis_up 31850358 hsa-mir-145 Hyperlipidemias Results: Comparative with control group, in hypertension associated with hyperlipidemia the investigated miRNA expression profiles were different: (i) in plasma, the levels of all investigated miRNAs were significantly increased, the highest enhances being noticed for miR-21,-146a,-221,-143,-34a, and miR-204; (ii) in platelets, the expressions of almost all miRNAs were significantly elevated, remarkable for miR-126,-146a,-223,-222, and miR-214, while levels of miR-143, miR-10a, and miR-145 were significantly reduced; (iii) in PMVs, numerous miRNAs were found to have significantly increased levels, especially miR-222,-221,-210, and miR-34a, whereas expressions of various miRNAs as miR-223,-214,-146a,-143,-10a, and miR-145 were significantly decreased. +circulation_biomarker_diagnosis_up 31850358 hsa-mir-222 Hypertension Results: Comparative with control group, in hypertension associated with hyperlipidemia the investigated miRNA expression profiles were different: (i) in plasma, the levels of all investigated miRNAs were significantly increased, the highest enhances being noticed for miR-21,-146a,-221,-143,-34a, and miR-204; (ii) in platelets, the expressions of almost all miRNAs were significantly elevated, remarkable for miR-126,-146a,-223,-222, and miR-214, while levels of miR-143, miR-10a, and miR-145 were significantly reduced; (iii) in PMVs, numerous miRNAs were found to have significantly increased levels, especially miR-222,-221,-210, and miR-34a, whereas expressions of various miRNAs as miR-223,-214,-146a,-143,-10a, and miR-145 were significantly decreased. +circulation_biomarker_diagnosis_up 31850358 hsa-mir-21 Hypertension Methods: Seventeen selected circulating miRNAs (miR-19a,-21,-126,-146a,-223,-26b,-92a,-222,-210,- and miR-214) were individually analyzed in plasma, platelets, and PMVs isolated from peripheral blood of hypertensive-hyperlipidemic hamsters treated or not with endothelial progenitor cells (EPCs), and of healthy hamsters taken as control group. Results: Comparative with control group, in hypertension associated with hyperlipidemia the investigated miRNA expression profiles were different: (i) in plasma, the levels of all investigated miRNAs were significantly increased, the highest enhances being noticed for miR-21,-146a,-221,-143,-34a, and miR-204; (ii) in platelets, the expressions of almost all miRNAs were significantly elevated, remarkable for miR-126,-146a,-223,-222, and miR-214, while levels of miR-143, miR-10a, and miR-145 were significantly reduced; (iii) in PMVs, numerous miRNAs were found to have significantly increased levels, especially miR-222,-221,-210, and miR-34a, whereas expressions of various miRNAs as miR-223,-214,-146a,-143,-10a, and miR-145 were significantly decreased. +circulation_biomarker_diagnosis_up 31850358 hsa-mir-21 Hyperlipidemias Methods: Seventeen selected circulating miRNAs (miR-19a,-21,-126,-146a,-223,-26b,-92a,-222,-210,- and miR-214) were individually analyzed in plasma, platelets, and PMVs isolated from peripheral blood of hypertensive-hyperlipidemic hamsters treated or not with endothelial progenitor cells (EPCs), and of healthy hamsters taken as control group. Results: Comparative with control group, in hypertension associated with hyperlipidemia the investigated miRNA expression profiles were different: (i) in plasma, the levels of all investigated miRNAs were significantly increased, the highest enhances being noticed for miR-21,-146a,-221,-143,-34a, and miR-204; (ii) in platelets, the expressions of almost all miRNAs were significantly elevated, remarkable for miR-126,-146a,-223,-222, and miR-214, while levels of miR-143, miR-10a, and miR-145 were significantly reduced; (iii) in PMVs, numerous miRNAs were found to have significantly increased levels, especially miR-222,-221,-210, and miR-34a, whereas expressions of various miRNAs as miR-223,-214,-146a,-143,-10a, and miR-145 were significantly decreased. +circulation_biomarker_diagnosis_up 31850358 hsa-mir-222 Hyperlipidemias Results: Comparative with control group, in hypertension associated with hyperlipidemia the investigated miRNA expression profiles were different: (i) in plasma, the levels of all investigated miRNAs were significantly increased, the highest enhances being noticed for miR-21,-146a,-221,-143,-34a, and miR-204; (ii) in platelets, the expressions of almost all miRNAs were significantly elevated, remarkable for miR-126,-146a,-223,-222, and miR-214, while levels of miR-143, miR-10a, and miR-145 were significantly reduced; (iii) in PMVs, numerous miRNAs were found to have significantly increased levels, especially miR-222,-221,-210, and miR-34a, whereas expressions of various miRNAs as miR-223,-214,-146a,-143,-10a, and miR-145 were significantly decreased. +circulation_biomarker_diagnosis_up 31850358 hsa-mir-126 Hypertension Results: Comparative with control group, in hypertension associated with hyperlipidemia the investigated miRNA expression profiles were different: (i) in plasma, the levels of all investigated miRNAs were significantly increased, the highest enhances being noticed for miR-21,-146a,-221,-143,-34a, and miR-204; (ii) in platelets, the expressions of almost all miRNAs were significantly elevated, remarkable for miR-126,-146a,-223,-222, and miR-214, while levels of miR-143, miR-10a, and miR-145 were significantly reduced; (iii) in PMVs, numerous miRNAs were found to have significantly increased levels, especially miR-222,-221,-210, and miR-34a, whereas expressions of various miRNAs as miR-223,-214,-146a,-143,-10a, and miR-145 were significantly decreased. +circulation_biomarker_diagnosis_up 31850358 hsa-mir-214 Hyperlipidemias Methods: Seventeen selected circulating miRNAs (miR-19a,-21,-126,-146a,-223,-26b,-92a,-222,-210,- and miR-214) were individually analyzed in plasma, platelets, and PMVs isolated from peripheral blood of hypertensive-hyperlipidemic hamsters treated or not with endothelial progenitor cells (EPCs), and of healthy hamsters taken as control group. Results: Comparative with control group, in hypertension associated with hyperlipidemia the investigated miRNA expression profiles were different: (i) in plasma, the levels of all investigated miRNAs were significantly increased, the highest enhances being noticed for miR-21,-146a,-221,-143,-34a, and miR-204; (ii) in platelets, the expressions of almost all miRNAs were significantly elevated, remarkable for miR-126,-146a,-223,-222, and miR-214, while levels of miR-143, miR-10a, and miR-145 were significantly reduced; (iii) in PMVs, numerous miRNAs were found to have significantly increased levels, especially miR-222,-221,-210, and miR-34a, whereas expressions of various miRNAs as miR-223,-214,-146a,-143,-10a, and miR-145 were significantly decreased. +circulation_biomarker_diagnosis_up 31850358 hsa-mir-126 Hyperlipidemias Results: Comparative with control group, in hypertension associated with hyperlipidemia the investigated miRNA expression profiles were different: (i) in plasma, the levels of all investigated miRNAs were significantly increased, the highest enhances being noticed for miR-21,-146a,-221,-143,-34a, and miR-204; (ii) in platelets, the expressions of almost all miRNAs were significantly elevated, remarkable for miR-126,-146a,-223,-222, and miR-214, while levels of miR-143, miR-10a, and miR-145 were significantly reduced; (iii) in PMVs, numerous miRNAs were found to have significantly increased levels, especially miR-222,-221,-210, and miR-34a, whereas expressions of various miRNAs as miR-223,-214,-146a,-143,-10a, and miR-145 were significantly decreased. +circulation_biomarker_diagnosis_up 31850358 hsa-mir-10a Hyperlipidemias Results: Comparative with control group, in hypertension associated with hyperlipidemia the investigated miRNA expression profiles were different: (i) in plasma, the levels of all investigated miRNAs were significantly increased, the highest enhances being noticed for miR-21,-146a,-221,-143,-34a, and miR-204; (ii) in platelets, the expressions of almost all miRNAs were significantly elevated, remarkable for miR-126,-146a,-223,-222, and miR-214, while levels of miR-143, miR-10a, and miR-145 were significantly reduced; (iii) in PMVs, numerous miRNAs were found to have significantly increased levels, especially miR-222,-221,-210, and miR-34a, whereas expressions of various miRNAs as miR-223,-214,-146a,-143,-10a, and miR-145 were significantly decreased. +circulation_biomarker_diagnosis_up 31850358 hsa-mir-10a Hypertension Results: Comparative with control group, in hypertension associated with hyperlipidemia the investigated miRNA expression profiles were different: (i) in plasma, the levels of all investigated miRNAs were significantly increased, the highest enhances being noticed for miR-21,-146a,-221,-143,-34a, and miR-204; (ii) in platelets, the expressions of almost all miRNAs were significantly elevated, remarkable for miR-126,-146a,-223,-222, and miR-214, while levels of miR-143, miR-10a, and miR-145 were significantly reduced; (iii) in PMVs, numerous miRNAs were found to have significantly increased levels, especially miR-222,-221,-210, and miR-34a, whereas expressions of various miRNAs as miR-223,-214,-146a,-143,-10a, and miR-145 were significantly decreased. +circulation_biomarker_diagnosis_up 31850358 hsa-mir-34a Hyperlipidemias Results: Comparative with control group, in hypertension associated with hyperlipidemia the investigated miRNA expression profiles were different: (i) in plasma, the levels of all investigated miRNAs were significantly increased, the highest enhances being noticed for miR-21,-146a,-221,-143,-34a, and miR-204; (ii) in platelets, the expressions of almost all miRNAs were significantly elevated, remarkable for miR-126,-146a,-223,-222, and miR-214, while levels of miR-143, miR-10a, and miR-145 were significantly reduced; (iii) in PMVs, numerous miRNAs were found to have significantly increased levels, especially miR-222,-221,-210, and miR-34a, whereas expressions of various miRNAs as miR-223,-214,-146a,-143,-10a, and miR-145 were significantly decreased. +circulation_biomarker_diagnosis_up 31850358 hsa-mir-143 Hypertension Results: Comparative with control group, in hypertension associated with hyperlipidemia the investigated miRNA expression profiles were different: (i) in plasma, the levels of all investigated miRNAs were significantly increased, the highest enhances being noticed for miR-21,-146a,-221,-143,-34a, and miR-204; (ii) in platelets, the expressions of almost all miRNAs were significantly elevated, remarkable for miR-126,-146a,-223,-222, and miR-214, while levels of miR-143, miR-10a, and miR-145 were significantly reduced; (iii) in PMVs, numerous miRNAs were found to have significantly increased levels, especially miR-222,-221,-210, and miR-34a, whereas expressions of various miRNAs as miR-223,-214,-146a,-143,-10a, and miR-145 were significantly decreased. +circulation_biomarker_diagnosis_up 31850358 hsa-mir-143 Hyperlipidemias Results: Comparative with control group, in hypertension associated with hyperlipidemia the investigated miRNA expression profiles were different: (i) in plasma, the levels of all investigated miRNAs were significantly increased, the highest enhances being noticed for miR-21,-146a,-221,-143,-34a, and miR-204; (ii) in platelets, the expressions of almost all miRNAs were significantly elevated, remarkable for miR-126,-146a,-223,-222, and miR-214, while levels of miR-143, miR-10a, and miR-145 were significantly reduced; (iii) in PMVs, numerous miRNAs were found to have significantly increased levels, especially miR-222,-221,-210, and miR-34a, whereas expressions of various miRNAs as miR-223,-214,-146a,-143,-10a, and miR-145 were significantly decreased. +circulation_biomarker_diagnosis_up 31850358 hsa-mir-214 Hypertension Methods: Seventeen selected circulating miRNAs (miR-19a,-21,-126,-146a,-223,-26b,-92a,-222,-210,- and miR-214) were individually analyzed in plasma, platelets, and PMVs isolated from peripheral blood of hypertensive-hyperlipidemic hamsters treated or not with endothelial progenitor cells (EPCs), and of healthy hamsters taken as control group. Results: Comparative with control group, in hypertension associated with hyperlipidemia the investigated miRNA expression profiles were different: (i) in plasma, the levels of all investigated miRNAs were significantly increased, the highest enhances being noticed for miR-21,-146a,-221,-143,-34a, and miR-204; (ii) in platelets, the expressions of almost all miRNAs were significantly elevated, remarkable for miR-126,-146a,-223,-222, and miR-214, while levels of miR-143, miR-10a, and miR-145 were significantly reduced; (iii) in PMVs, numerous miRNAs were found to have significantly increased levels, especially miR-222,-221,-210, and miR-34a, whereas expressions of various miRNAs as miR-223,-214,-146a,-143,-10a, and miR-145 were significantly decreased. +circulation_biomarker_diagnosis_up 31850358 hsa-mir-34a Hypertension Results: Comparative with control group, in hypertension associated with hyperlipidemia the investigated miRNA expression profiles were different: (i) in plasma, the levels of all investigated miRNAs were significantly increased, the highest enhances being noticed for miR-21,-146a,-221,-143,-34a, and miR-204; (ii) in platelets, the expressions of almost all miRNAs were significantly elevated, remarkable for miR-126,-146a,-223,-222, and miR-214, while levels of miR-143, miR-10a, and miR-145 were significantly reduced; (iii) in PMVs, numerous miRNAs were found to have significantly increased levels, especially miR-222,-221,-210, and miR-34a, whereas expressions of various miRNAs as miR-223,-214,-146a,-143,-10a, and miR-145 were significantly decreased. +circulation_biomarker_diagnosis_up 31850358 hsa-mir-145 Hypertension Results: Comparative with control group, in hypertension associated with hyperlipidemia the investigated miRNA expression profiles were different: (i) in plasma, the levels of all investigated miRNAs were significantly increased, the highest enhances being noticed for miR-21,-146a,-221,-143,-34a, and miR-204; (ii) in platelets, the expressions of almost all miRNAs were significantly elevated, remarkable for miR-126,-146a,-223,-222, and miR-214, while levels of miR-143, miR-10a, and miR-145 were significantly reduced; (iii) in PMVs, numerous miRNAs were found to have significantly increased levels, especially miR-222,-221,-210, and miR-34a, whereas expressions of various miRNAs as miR-223,-214,-146a,-143,-10a, and miR-145 were significantly decreased. +lncRNA target 31850259 hsa-mir-664 Osteosarcoma 3p may become a novel molecular biological indicator for the diagnosis, targeted treatment and prognosis assessment of osteosarcoma. +genetics_overexpression_suppress 31850191 hsa-mir-204 Urinary Bladder Neoplasms Overexpression of LDHA relieved the growth inhibition and cell apoptosis enhancement by miR +transcription factor target 31850164 hsa-mir-29b neovascular inflammatory vitreoretinopathy CONCLUSION: Our findings are crucial steps in determining the critical roles of the PI3K/Akt signaling pathway and miRNA-29b in pathogenesis of proliferative vitreoretinopathy (PVR) which may be a potential target for preventing or treating PVR. +transcription factor target 31850164 hsa-mir-29b Vitreoretinopathy, Proliferative CONCLUSION: Our findings are crucial steps in determining the critical roles of the PI3K/Akt signaling pathway and miRNA-29b in pathogenesis of proliferative vitreoretinopathy (PVR) which may be a potential target for preventing or treating PVR. +lncRNA target 31849582 hsa-mir-409 Alzheimer Disease 5p in AD progression might be a self-protective reaction to alleviate the synaptic damage induced by Abeta, which may be used as a potential early biomarker of AD. +circulation_biomarker_diagnosis_ns 31849573 hsa-mir-132 Alzheimer Disease ROC analysis indicated that measurement of miR3p in neurally-derived plasma EVs showed good sensitivity and specificity to diagnose AD, but did not effectively separate individuals with AD-MCI from controls. +other 31849573 hsa-mir-212 Alzheimer Disease Moreover, when we measured the levels of a related miRNA, miR-212, we found that this miRNA was also decreased in neural EVs from AD patients compared to controls. Our results suggest that measurement of miR-132 and miR-212 in neural EVs should be further investigated as a diagnostic aid for AD and as a potential theragnostic. +lncRNA target 31849534 hsa-mir-140 Squamous Cell Carcinoma of Head and Neck 5p/SOX4 axis might be a ponderable and promising therapeutic target for OSCC. +lncRNA target 31849524 hsa-mir-1286 Osteosarcoma MYOSLID was the sponge for miR-1286 and inhibited its expression while miR-1286 targeted RAB13 directly. +genetics_knock down_promote 31849520 hsa-mir-221 Uterine Cervical Neoplasms 3p and MAPK10 on cell activities were assessed through gain- and loss-of-function experiments in CC. +transcription factor target 31849517 hsa-mir-431 Colonic Neoplasms 5p, promotes proliferation and invasion via an autophagy-dependent manner in colon cancer suggesting that miR +genetics_overexpression_suppress 31849505 hsa-mir-452 Spinal Cord Injuries CONCLUSION: GAS5 overexpression inhibited the inflammation, oxidative stress and pyroptosis of HG-induced renal tubular cells by downregulating the expression of miR +other 31849498 hsa-mir-2276 Glioma CONCLUSION: Our findings identified the essential roles of the BCAR4/miR-2276/MMP7 axis in gliomagenesis and provided novel insights on glioma therapy. +lncRNA target 31849497 hsa-mir-23b Carcinoma, Hepatocellular CONCLUSION: Our data suggested that LncRNA RP11-422N16.3, by competitively binding to miR-23b-3p, promoted DMGDH expression, contributing to inhibit cell proliferation and EMT, and induce cell apoptosis in hepatocellular carcinoma cells. +genetics_knock down_promote 31849491 hsa-mir-181a Nasopharyngeal Carcinoma Moreover, both in vitro and in vivo experimental outcomes indicated that RKIP restoration and knockdown could antagonize the effects of miR-181a and miR-181a inhibitor in the regulation of NPC radioresistance. +exosome 31849488 hsa-mir-545 Laryngeal Neoplasms CONCLUSION: Exosome-mediated HOTAIR acts as a ceRNA of miR3p to regulate E2F2, thereby negatively regulating the radiosensitivity of laryngeal cancer cells. +lncRNA target 31849487 hsa-mir-145 Colorectal Neoplasms RESULTS: The miR-145 mimics suppressed CRC cell invasion and migration significantly; in contrast, miR-145 downregulation had the opposite effect. +genetics_overexpression_promote 31849486 hsa-mir-204 Carcinoma, Non-Small-Cell Lung 5p and ATG3 overexpression restored the effect of miR +lncRNA target 31849480 hsa-mir-497 Uterine Cervical Neoplasms 5p inhibits cervical cancer cells proliferation by directly targeting CBX4. +lncRNA target 31849465 hsa-mir-155 Urinary Bladder Neoplasms Intercellular transport of miR-155 via TNTs can promote bladder cancer cell reprogramming by Deptor-mTOR signal pathway activation. +circRNA target 31848327 hsa-mir-7223 Fractures, Bone 5p/PIK3R1 axis are potential therapeutic targets for improving fracture healing. +lncRNA target 31848324 hsa-mir-496 Urinary Bladder Neoplasms HMGB1 was identified as a direct target gene of miR-496 in bladder cancer, and HMGB1 expression was enhanced by NNT-AS1 via sponging of miR-496. +genetics_overexpression_promote 31847632 hsa-mir-421 Reperfusion Injury CONCLUSIONS: Overexpression of miRNA-421 could reduce ischemia/reperfusion inflammatory response, perhaps via inactivation of TLR4, JAK2, and STAT3. +circulation_biomarker_prognosis_up 31847527 hsa-mir-1203 Carcinoma, Hepatocellular Circulating expression of miR-1203 and SOCS3 might serve as a predictor of metastases and poor prognosis in HCC patients. +other 31847440 hsa-mir-19a Vitreous Hemorrhage miRNA-19a and -27a were detected as putative vitreous biomarkers for PDR, and elevated levels of miRNA-20a and -93 in vitreous with RVH suggest their biomarker potential for major PDR complications such as recurrent hemorrhage incidence. +other 31847440 hsa-mir-27a Diabetic Retinopathy miRNA-19a and -27a were detected as putative vitreous biomarkers for PDR, and elevated levels of miRNA-20a and -93 in vitreous with RVH suggest their biomarker potential for major PDR complications such as recurrent hemorrhage incidence. +other 31847440 hsa-mir-27a Vitreous Hemorrhage miRNA-19a and -27a were detected as putative vitreous biomarkers for PDR, and elevated levels of miRNA-20a and -93 in vitreous with RVH suggest their biomarker potential for major PDR complications such as recurrent hemorrhage incidence. +other 31847440 hsa-mir-93 Vitreous Hemorrhage miRNA-19a and -27a were detected as putative vitreous biomarkers for PDR, and elevated levels of miRNA-20a and -93 in vitreous with RVH suggest their biomarker potential for major PDR complications such as recurrent hemorrhage incidence. +other 31847440 hsa-mir-19a Diabetic Retinopathy miRNA-19a and -27a were detected as putative vitreous biomarkers for PDR, and elevated levels of miRNA-20a and -93 in vitreous with RVH suggest their biomarker potential for major PDR complications such as recurrent hemorrhage incidence. +other 31847440 hsa-mir-20a Vitreous Hemorrhage miRNA-19a and -27a were detected as putative vitreous biomarkers for PDR, and elevated levels of miRNA-20a and -93 in vitreous with RVH suggest their biomarker potential for major PDR complications such as recurrent hemorrhage incidence. +other 31847440 hsa-mir-20a Diabetic Retinopathy miRNA-19a and -27a were detected as putative vitreous biomarkers for PDR, and elevated levels of miRNA-20a and -93 in vitreous with RVH suggest their biomarker potential for major PDR complications such as recurrent hemorrhage incidence. +other 31847440 hsa-mir-93 Diabetic Retinopathy miRNA-19a and -27a were detected as putative vitreous biomarkers for PDR, and elevated levels of miRNA-20a and -93 in vitreous with RVH suggest their biomarker potential for major PDR complications such as recurrent hemorrhage incidence. +transcription factor target 31847412 hsa-mir-200b Prekallikrein Deficiency Conclusions: PKP2 deficiency alters cardiomyocytes adhesion through a mechanism that involves upregulation of miR-200b and suppression of Itga1 expression. +transcription factor target 31847412 hsa-mir-200 Prekallikrein Deficiency Conclusions: PKP2 deficiency alters cardiomyocytes adhesion through a mechanism that involves upregulation of miR-200b and suppression of Itga1 expression. +other 31847394 hsa-mir-375 Neoplasms, Germ Cell and Embryonal Finally, we show the value of our identification model in a specific scenario, contradicting the presumed role of miR-375 as marker of teratoma histology in liquid biopsy setting. +lncRNA target 31847321 hsa-mir-127 Osteosarcoma 3p and miR-376a-3p mimics significantly inhibited proliferation and reduced the colony formation capacity of these cells. +lncRNA target 31847321 hsa-mir-376a Osteosarcoma 3p and miR-376a-3p mimics significantly inhibited proliferation and reduced the colony formation capacity of these cells. +other 31847264 hsa-mir-223 Diabetic Retinopathy In summary, in the DR environment, TTR might affect the lncRNA MEG3/miR3p axis by the direct binding with PABPC1, and finally repress retinal vessel proliferation. +lncRNA target 31846800 hsa-mir-15a Carcinoma, Pancreatic Ductal We demonstrated enhanced inhibition of PDAC cell proliferation by 5-FU-miR-15a compared to native miR-15a. +lncRNA target 31846694 hsa-mir-1 Carcinoma, Hepatocellular Furthermore, mutant ACTB mRNA 3'-UTR promoted hepatocellular carcinoma cells migration and invasion in vitro and in vivo by up-regulating miR-1 target gene MET and miR-29a target gene MCL1. +lncRNA target 31846694 hsa-mir-29a Carcinoma, Hepatocellular Furthermore, mutant ACTB mRNA 3'-UTR promoted hepatocellular carcinoma cells migration and invasion in vitro and in vivo by up-regulating miR-1 target gene MET and miR-29a target gene MCL1. +lncRNA target 31846689 hsa-mir-646 Prostatic Neoplasms Mechanism dissection revealed that R-2HG could increase circRNA-51217 expression to sponge miRNA-646, which might then lead to increase TGFbeta1 expression and thus induce TGFbeta1/p-Smad2/3 signaling to increase PCa cell invasion. AR can suppress this R-2HG/circRNA-51217/miRNA-646/TGFbeta1/p-Smad2/3 signaling-increased PCa cell invasion via repressing TGFbeta1 transcription and inhibiting circRNA-51217 expression through regulating ADAR2 expression. +genetics_overexpression_promote 31846199 hsa-mir-150 Stomach Neoplasms MiR-150 inhibition and IRX1 overexpression in SNU-1 cells restricted viability, colony formation, migration, and invasion abilities, but boosted apoptosis of gastric cancer cells in vitro, and also repressed tumor growth in vivo. +genetics_knock down_suppress 31846044 hsa-mir-214 ankylosing spondylitis 1 The aim of this study was to investigate the effect of miR-214, the production of which is stimulated by IL-17A, on bone loss in AS. +lncRNA target 31845557 hsa-mir-484 Reperfusion Injury MiR-484 might alleviate the decreasing of mitochondrial membrane potential in MI/R cells. +circRNA target 31845519 hsa-mir-503 Stomach Neoplasms CONCLUSION: Circ_0000267 is an oncogenic circRNA that affects the progression of GC, which participates in promotion of GC proliferation, migration, invasion, and EMT via modulating the miR +transcription factor target 31845227 hsa-mir-155 Wounds and Injuries MiR-155 regulated IL-17/ILrelated inflammation in wound healing and might be a potential therapeutic target to attenuate the inflammatory response in wound tissue and promote the closure of wound injuries. +lncRNA target 31845077 hsa-mir-367 Cardiomegaly These findings unveiled the pivotal role of the miR302-367 cluster in regulating cardiac autophagy and therefore modulating cardiac hypertrophy through PTEN/PI3K/AKT/mTORC1 signaling, indicating a promising therapeutic strategy for cardiac hypertrophy and even heart failure. +circulation_biomarker_diagnosis_up 31844676 hsa-mir-663b Acute Lymphoblastic Leukemia, T-Cell In the present study, we found that miR-663b was up-regulated in the blood of children with T-ALL and T-ALL cell lines. +other 31844675 hsa-mir-767 Prostatic Neoplasms Moreover, miR5p was found to be resistant to EnzR cells when the level of circUCK2 is increased. +genetics_knock down_promote 31844658 hsa-mir-24 Hyperlipoproteinemia Type II Here, we show that loss of miR-23~27~24 clusters in T cells resulted in elevated T(FH) cell frequencies upon different immune challenges, whereas overexpression of this miRNA family led to reduced T(FH) cell responses. Mechanistically, miR-23~27~24 clusters coordinately control T(FH) cells through targeting a network of genes that are crucial for T(FH) cell biology. +genetics_knock down_promote 31844658 hsa-mir-27 Hyperlipoproteinemia Type II Here, we show that loss of miR-23~27~24 clusters in T cells resulted in elevated T(FH) cell frequencies upon different immune challenges, whereas overexpression of this miRNA family led to reduced T(FH) cell responses. Mechanistically, miR-23~27~24 clusters coordinately control T(FH) cells through targeting a network of genes that are crucial for T(FH) cell biology. +genetics_knock down_promote 31844658 hsa-mir-23 Hyperlipoproteinemia Type II Here, we show that loss of miR-23~27~24 clusters in T cells resulted in elevated T(FH) cell frequencies upon different immune challenges, whereas overexpression of this miRNA family led to reduced T(FH) cell responses. Mechanistically, miR-23~27~24 clusters coordinately control T(FH) cells through targeting a network of genes that are crucial for T(FH) cell biology. +lncRNA target 31844419 hsa-mir-214 Lymphoma, Large B-Cell, Diffuse CONCLUSION: By targeting PD-L1, miR-214 regulates the progression of DLBCL in vitro and in vivo. +other 31844418 hsa-mir-376c hyper IgE recurrent infection syndrome 2 BACKGROUND: The expression level of miR-376c-3p is significantly lower in infants with neonatal hypoxic-ischemic encephalopathy (HIE) than in healthy infants. +other 31844418 hsa-mir-376c Hypoxia-Ischemia, Brain BACKGROUND: The expression level of miR-376c-3p is significantly lower in infants with neonatal hypoxic-ischemic encephalopathy (HIE) than in healthy infants. +lncRNA target 31844417 hsa-mir-582 Leukemia, Myeloid, Acute 3p and CCNB2 are potential therapeutic targets for the treatment of AML. +lncRNA target 31844042 hsa-mir-182 Carcinoma, Non-Small-Cell Lung Circ_0002483 was demonstrated to inhibit NSCLC progression in vitro and in vivo and enhanced the sensitivity of NSCLC cells to Taxol by sponging miR5p to release the inhibition on GRB2, FOXO1, and FOXO3 mRNAs. +genetics_overexpression_promote 31844033 hsa-mir-203 Esophageal Neoplasms Additionally, gene expression profiles and bioinformatics analysis revealed KIF5C to be a direct target of miR-203, and KIF5C overexpression partially counteracted the tumor inhibitory effects of miR-203 on EC cells. +lncRNA target 31843814 hsa-mir-218 Urinary Bladder Neoplasms MNX1-AS1 regulates RAB1A expression to promote proliferation, migration, invasion, and epithelial-mesenchymal transitions of bladder cancer cells via miR +transcription factor target 31843555 hsa-mir-525 Prostatic Neoplasms 5p transcription in PCa or decrease it in BCa via binding to different androgen-response-elements (AREs) located at different positions in the miR-525 precursor promoter. +transcription factor target 31843555 hsa-mir-525 Urinary Bladder Neoplasms 5p transcription in PCa or decrease it in BCa via binding to different androgen-response-elements (AREs) located at different positions in the miR-525 precursor promoter. +other 31843527 hsa-mir-130a Hernias, Diaphragmatic, Congenital SIGNIFICANCE: This study was the first to show that the miR-130a-5p/Foxa2 axis played a crucial role in CDH-associated pulmonary hypoplasia. +exosome 31843449 hsa-mir-124 Brain Injuries, Traumatic We demonstrated that miR3p level in microglial exosomes from injured brain was significantly altered in the acute, sub-acute, and chronic phases after rmTBI. +exosome 31843449 hsa-mir-124 Nerve Degeneration We demonstrated that miR3p level in microglial exosomes from injured brain was significantly altered in the acute, sub-acute, and chronic phases after rmTBI. +transcription factor target 31843095 hsa-mir-29c Leiomyoma Using 3' untranslated region luciferase reporter assay we confirmed that TGF-beta3 is a direct target of miR-29c in leiomyoma smooth muscle cells (LSMCs). +exosome 31842997 hsa-mir-4532 Leukemia, Myeloid, Acute CONCLUSION: In conclusion, AML cell-derived exosomes carrying miR-4532 repress normal HSC hematopoiesis via activation of the LDOC1-dependent STAT3 signaling pathway. +other 31842980 hsa-mir-222 Implantation Failure The miR-222GT+TT genotypes interacted with high prothrombin time (>/= 12 s) to increase the risk of RIF. +exosome 31842978 hsa-mir-133b Glioma CONCLUSION: Collectively, the obtained results suggested that MSC-derived exosomes carrying miR-133b could attenuate glioma development via disrupting the Wnt/beta-catenin signaling pathway by inhibiting EZH2, which provides a potential treatment biomarker for glioma. +circulation_biomarker_prognosis_ns 31842954 hsa-mir-222 Pneumonia, Mycoplasma 3p and lower levels of CD4 in peripheral blood plasma (P < 0.05). +genetics_overexpression_promote 31842953 hsa-mir-338 Ovarian Neoplasms Overexpression miR +other 31842912 hsa-mir-181a Thyroid Cancer, Papillary CONCLUSIONS: The results of this study suggested that hsa-miR-181a-5p and BCL2 and their regulatory networks may play important roles in the pathogenesis of PTC. +other 31842825 hsa-mir-15a Small Cell Lung Carcinoma We found that LUADT1 and Twist1 were upregulated in SCLC, while miR-15a-3p was downregulated in SCLC. Therefore, LUADT1 may sponge miR-15a-3p to upregulate Twist1 in SCLC, thereby promoting cancer cell invasion and migration. +circulation_biomarker_diagnosis_ns 31842577 hsa-mir-29b Prostatic Neoplasms The primary aim of our present study was to investigate the effect of exercise training to changes in body composition (muscle strength) and the secondary endpoint was to investigate the impact of an exercise training program on plasma levels of selected myogenic microRNAs (miRNAs) (miRNA-1, miRNA-29b, and miRNA-133) in PC patients undergoing the ADT. +circulation_biomarker_diagnosis_ns 31842577 hsa-mir-1 Prostatic Neoplasms The primary aim of our present study was to investigate the effect of exercise training to changes in body composition (muscle strength) and the secondary endpoint was to investigate the impact of an exercise training program on plasma levels of selected myogenic microRNAs (miRNAs) (miRNA-1, miRNA-29b, and miRNA-133) in PC patients undergoing the ADT. +lncRNA target 31842477 hsa-mir-374b Cystadenocarcinoma, Serous, Ovarian We conclude that MAGI2-AS3 acts as a tumor suppressor in EOC, specifically in HGSC by sponging miR5p, miR-374a-5p and miR-374b-5p, and altering downstream signaling of certain mRNAs through a ceRNA network. +transcription factor target 31841992 hsa-mir-21 Osteoarthritis Therefore, extracellular miR-21 released from synovial tissue mediates knee OA pain through TLR7 activation in surgical OA model rats. +other 31841991 hsa-mir-21 Hepatitis The results showed that the miR-21 DNAzyme-RNV-L7 aptamer chimera efficiently reduced the expression of miR-21 in Huh-7 liver cancer cells. +transcription factor target 31841757 hsa-mir-92a Acute Lung Injury Together, these results reveal an important role of miR-92a in LPS-induced endothelial barrier dysfunction, and suggest that miR-92a may have potential as a prognostic indicator and a future target for the treatment of acute lung injury (ALI)/ARDS. +transcription factor target 31841757 hsa-mir-92a Respiratory Distress Syndrome Together, these results reveal an important role of miR-92a in LPS-induced endothelial barrier dysfunction, and suggest that miR-92a may have potential as a prognostic indicator and a future target for the treatment of acute lung injury (ALI)/ARDS. +lncRNA target 31841752 hsa-mir-370 Pneumonia 3p targeted IGF2 and inhibited LPS-induced inflammatory injury via IGF2 in A549 cells. +other 31841454 hsa-mir-185 Carcinoma, Hepatocellular CONCLUSIONS LncRNA FOXD2-AS1 promoted hepatocellular carcinoma development by regulation miR-185/AKT axis. +genetics_overexpression_promote 31841443 hsa-mir-144 Hematoma, Subdural, Chronic Overexpression of miR +genetics_overexpression_promote 31841213 hsa-mir-1290 Squamous Cell Carcinoma of Head and Neck Furthermore, overexpression of CCNG2 weakened the promoted effect of miR-1290 on cell metastasis in OSCC. +other 31841198 hsa-mir-129 Thyroid Neoplasms Moreover, DARS-AS1 could promote the proliferation and migration capabilities of thyroid cancer cells by modulating microRNA-129. +genetics_overexpression_suppress 31841197 hsa-mir-92b Triple Negative Breast Neoplasms In addition, low expression of miR-92b or overexpression of Gabra3 predicted poor prognosis of TNBC patients. +transcription factor target 31841196 hsa-mir-296 Breast Neoplasms Additionally, miR-296 up-regulation could inhibit in vivo BC cell growth. +lncRNA target 31841194 hsa-mir-143 Breast Neoplasms CONCLUSIONS: In this study, we verified that LncRNA LOXL1-AS1 inhibited cell proliferation, migration and invasion as well as induced apoptosis in breast cancer via regulating miR +lncRNA target 31841192 hsa-mir-493 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: LINC01605 is upregulated in LSCC tissues, and it promotes the malignant progression of LSCC via targeting miR +lncRNA target 31841191 hsa-mir-141 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: MiR-141 promoted the proliferation and invasion by targeting the KLF9 in non-small cell lung cancer, and the newly identified miR-141/KLF9 axis provides novel insight into the pathogenesis of non-small cell lung cancer. +lncRNA target 31841190 hsa-mir-199a Carcinoma, Non-Small-Cell Lung CONCLUSIONS: MiR-199a prevents the proliferation of NSCLC cells via the targeted down-regulation of the HIF-1alpha/VEGF signaling pathway. +other 31841189 hsa-mir-4677 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: These results indicated that LINC02418 functions as an oncogene, and regulated miR3p/SEC61G axis to accelerate NSCLC progression. +lncRNA target 31841187 hsa-mir-126 Squamous Cell Carcinoma of Head and Neck It is suggested that miR-126/ADAM9 axis may play an essential role in inhibiting the abilities of migration and invasion in oral squamous cell carcinoma cells. +genetics_knock down_promote 31841186 hsa-mir-142 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: LncRNA BLACAT1 knockdown suppressed the viability, migration and invasion of OSCC cells by sponging miR +genetics_knock down_suppress 31841185 hsa-mir-431 Squamous Cell Carcinoma of Head and Neck 5p reversed the effects of circ_0001742 knockdown on proliferation, apoptosis, migration, invasion and EMT of TSCC cells. +other 31841184 hsa-mir-124 Stomach Neoplasms OBJECTIVE: The aim of this study was to explore the effect of circ MTHFD2 on resistance to pemetrexed (MTA) in gastric cancer by regulating the expression of micro ribonucleic acid (miR)-124. +lncRNA target 31841182 hsa-mir-16 Carcinoma, Hepatocellular CONCLUSIONS: We stated that miR-16 suppressed HCC cell progression by targeting FEAT and inhibiting EMT and NF-kappaB pathway. +genetics_overexpression_suppress 31841181 hsa-mir-490 Liver Neoplasms In vitro experiments confirmed that overexpression of microRNA +lncRNA target 31841179 hsa-mir-588 Carcinoma, Renal Cell Through the above experiments, it was verified whether microRNA-588 could enhance the invasiveness and metastasis of renal cancer by targeting EIF5A2. +lncRNA target 31840934 hsa-mir-137 Schizophrenia WBP1L is a target of microRNA 137 (miR-137) and has been considered a candidate gene for schizophrenia (SCZ). +other 31840824 hsa-mir-203 Alcoholism CONCLUSION: There are sex differences in the expression of GABA(A) alpha5 and miR-203 in the brain of human alcoholics which are particularly marked in alcoholics with cirrhosis of the liver. +other 31840824 hsa-mir-203 Liver Cirrhosis CONCLUSION: There are sex differences in the expression of GABA(A) alpha5 and miR-203 in the brain of human alcoholics which are particularly marked in alcoholics with cirrhosis of the liver. +circRNA target 31840820 hsa-mir-19 Liver Diseases, Alcoholic Further, the crosstalk analysis of circRNA-miRNA revealed 7 miRNAs were targeted by mou_circ_1657, of which miR +circulation_biomarker_diagnosis_down 31839947 hsa-mir-192 Breast Neoplasms In the present study, we extracted RNA from both the serum and cancerous tissue of breast cancer patients and after synthesizing the cDNA, we performed quantitative PCR to determine the expression levels of miR-9 and miR-192. Based on the meaningful downregulation of the expression of miR-9 and miR-192, this study provides a plausible framework for these miRNAs as effective biomarkers for breast cancer patients. +other 31839944 hsa-mir-146b Thyroid Cancer, Papillary 3p were identified as key miRNAs in PTC. +other 31839944 hsa-mir-222 Thyroid Cancer, Papillary 3p were identified as key miRNAs in PTC. +other 31839944 hsa-mir-221 Thyroid Cancer, Papillary 3p were identified as key miRNAs in PTC. +other 31839944 hsa-mir-21 Thyroid Cancer, Papillary 3p were identified as key miRNAs in PTC. +other 31839944 hsa-mir-15a Thyroid Cancer, Papillary 3p were identified as key miRNAs in PTC. +genetics_overexpression_promote 31839907 hsa-mir-155 Vascular Remodeling Systemic miR155-5p overexpression reduced vascular ACE, angiotensin II and proliferating cell nuclear antigen levels, and attenuated hypertension and vascular remodelling in SHR. We concluded that WKY-EVs-mediated miR155-5p transfer attenuates VSMC proliferation and vascular remodelling in SHR via suppressing ACE expression, while SHR-EVs-mediated ACE transfer promotes VSMC proliferation and vascular remodelling. +genetics_overexpression_promote 31839907 hsa-mir-155 Hypertension Systemic miR155-5p overexpression reduced vascular ACE, angiotensin II and proliferating cell nuclear antigen levels, and attenuated hypertension and vascular remodelling in SHR. +genetics_overexpression_suppress 31839879 hsa-mir-29a Breast Neoplasms This miR-29a was found to be indeed overexpressed in a substantial number of Breast cancer patient samples and cell lines as well, suggesting one of the key mechanisms of PC4 downregulation. +transcription factor target 31839741 hsa-mir-221 Carcinoma, Hepatocellular Two HCC cell lines were treated with sorafenib and AuNPs-anti-miR221 alone or combination in vitro to investigate the inhibitory effect by CCK-8, live/dead fluorescence staining and colony-forming unit assays. +exosome 31839712 hsa-mir-139 Ovarian Neoplasms In addition, excessive miR-139 expression remarkably repressed the death and the expression of proteins related to cell death in OC cells, as well as inhibited the shedding of exosomes. +lncRNA target 31839421 hsa-mir-214 Cardiomyopathies CONCLUSION: Our findings demonstrated the novel molecular mechanism of RMRP/miR5p/p53 axis on the regulation of hypoxia-induced myocardial injury in H9c2 cells, which might provide potential therapeutic targets for AMI treatment. +lncRNA target 31839421 hsa-mir-214 Myocardial Infarction CONCLUSION: Our findings demonstrated the novel molecular mechanism of RMRP/miR5p/p53 axis on the regulation of hypoxia-induced myocardial injury in H9c2 cells, which might provide potential therapeutic targets for AMI treatment. +genetics_knock down_promote 31839366 hsa-mir-493 Breast Neoplasms Either miR-493 inhibition or FUT4 upregulation abrogated the consequences of GAS6-AS2 knockdown in BC cells. These results revealed that GAS6-AS2 sponges miR-493 to enhance the malignant characteristics of BC in vitro and in vivo by increasing FUT4 expression. +circulation_biomarker_prognosis_up 31839062 hsa-mir-609 Thalassemia CONCLUSION The increased level of serum miR-609 in patients with thalassemia is a risk factor for poor prognosis and can be used as a reference index for evaluating the efficacy for patients. +lncRNA target 31838741 hsa-mir-326 Carcinoma, Hepatocellular 5p), both of which are tumor suppressors in HCC. +lncRNA target 31838741 hsa-mir-532 Carcinoma, Hepatocellular 5p), both of which are tumor suppressors in HCC. +other 31838738 hsa-mir-29b Fluorosis, Dental The expression of hsa-miR-29b increased in fluorosis patients identified by the miRNA sequence analysis. +other 31838454 hsa-mir-191 Muscular Dystrophy, Duchenne On the other hand, miR-206 and miR5p were significantly downregulated in the majority of the DMD patients and the tested female family members. +other 31838454 hsa-mir-206 Muscular Dystrophy, Duchenne On the other hand, miR-206 and miR5p were significantly downregulated in the majority of the DMD patients and the tested female family members. +transcription factor target 31838391 hsa-mir-34a Liver Injury The present study provided in vivo evidence to reveal a potential mechanism for BDEinduced mitochondrial dysfunction and related liver injury and indicated that miR-34a-5p-mediated mitophagy impairment might be a therapeutic target for BDE-47 toxicity. +lncRNA target 31838022 hsa-mir-15 Herpes Simplex Specifically, we demonstrate that miR-K125p, an oncoviral mimic of the tumor suppressive miR-15/16 family encoded by human Kaposi sarcoma-associated herpes virus, harbors a noncanonical toxic 6mer seed (position 3-8) and that v-miRNAs are more likely than cellular miRNAs to utilize a noncanonical 6mer seed. +genetics_GWAS 31837604 hsa-mir-204 Retinal Degeneration Here, we investigated the therapeutic potential of miR-204 in IRDs. Our study highlights the mutation-independent therapeutic potential of AAV-miR204 in slowing down retinal degeneration in IRDs and unveils the previously unreported role of this miRNA in attenuating microglia activation and photoreceptor cell death. +genetics_overexpression_promote 31837602 hsa-mir-141 Stomach Neoplasms Bioinformatics analysis and functional experiments revealed that lncRNA MAGI2-AS3 was negatively correlated with miR-141/200a expression and negatively regulated miR-141/200a-3p expression in gastric cancer. Therefore, we speculate that lncRNA MAGI2-AS3 promotes tumor progression through sponging miR-141/200a and maintaining overexpression of ZEB1 in gastric cancer. +lncRNA target 31837588 hsa-mir-21 Pulpitis CONCLUSION: Evidence in this study suggested that BBR mediates LPS induced inflammation in HDPF via miR-21/KBTBD7 axis to regulate NF-kappaB signal pathway, which may provide theoretical basis for BBR in prevention of pulpitis. +transcription factor target 31837465 hsa-mir-149 Inflammation In summary, miR5p directly regulates CHI3L1 in context of TLR-mediated airway epithelial cell inflammation and may be a potential therapeutic target in inflammation and other diseases. +genetics_overexpression_promote 31837357 hsa-mir-212 Cholangiocarcinoma CONCLUSIONS: These findings suggest that aberrant hypermethylation-induced downregulation of miR3p results in overexpression of MUC13 in iCCA, leading to metastasis via activation of the EGFR/PI3K/AKT signaling pathway. +lncRNA target 31837336 hsa-mir-21 Ovarian Neoplasms Furthermore, M2 macrophages transfected with the miR-21 mimic significantly promoted chemoresistance and inhibited apoptosis of ovarian cancer cells, while the M2 macrophages transfected with the miR-21 inhibitor showed the opposite effects. +genetics_knock down_promote 31837329 hsa-mir-193a Leukemia, Myeloid, Acute Enrichment of miR-193a-3p decreased ADR resistance, inhibited proliferation, migration and invasion and stimulated apoptosis in ADR resistant AML cells, but Tspan3 overexpression overturned these impacts. +lncRNA target 31837324 hsa-mir-9 Brain Injuries Taken together, our data manifested that KCNQ1OT1 possibly acts as a facilitator in cerebral I/R injury through modulating miR-9/MMP8 axis as a ceRNA. +lncRNA target 31836741 hsa-mir-509 Osteosarcoma 3p/ARHGAP1 axes have the potential to uncover new druggable targets for the treatment of drug resistant metastatic osteosarcoma. +other 31836544 hsa-mir-574 Pre-Eclampsia 3p. +other 31836544 hsa-mir-1972 Pre-Eclampsia 3p. +other 31836544 hsa-mir-4793 Pre-Eclampsia 3p. +transcription factor target 31836508 hsa-mir-130a Fibrosis, Renal However, the relationship between miR-130a-3p and SnoN expression in the regulation of renal fibrosis is still unknown. CONCLUSION: Our study verified that miR-130a-3p facilitates the TGF-beta1/Smad pathway in renal tubular epithelial cells and may participate in renal fibrosis by targeting SnoN, which could be a possible strategy for renal fibrosis treatment. +genetics_overexpression_promote 31836324 hsa-mir-124 Stomach Neoplasms The overexpression or silencing of miR +lncRNA target 31836002 hsa-mir-142 Osteoarthritis Through bioinformatics analysis, we predicted that MCM3AP-AS1 may interact with miR +other 31834924 hsa-mir-710 Breast Neoplasms Using a previously validated oligonucleotide delivery system, we introduced miR-710 mimics into 4T1 metastatic breast adenocarcinoma cells and assessed the resultant phenotypic effects. +other 31834924 hsa-mir-710 Neoplasm Metastasis Using a previously validated oligonucleotide delivery system, we introduced miR-710 mimics into 4T1 metastatic breast adenocarcinoma cells and assessed the resultant phenotypic effects. +genetics_knock down_promote 31834525 hsa-mir-142a Encephalomyelitis, Enzootic Porcine Knockdown of Rab3a expression by transfection with an miR-142a-3p mimic or Rab3a siRNA significantly increased PHEV replication in N2a cells. +other 31833555 hsa-mir-142 Alzheimer Disease Since, selective, sensitive, simple and rapid method for detection of these miRNAs in a single test is critical for early diagnosis and efficient therapy of the disease, herein, we report a sensitive fluorescence assay based on enzyme-free and isothermal hybridization chain reaction with SYBR Green and graphene oxide (GOX) for early detection of miR-137 and miR-142, as two Alzheimer's biomarkers. +other 31833555 hsa-mir-137 Alzheimer Disease Since, selective, sensitive, simple and rapid method for detection of these miRNAs in a single test is critical for early diagnosis and efficient therapy of the disease, herein, we report a sensitive fluorescence assay based on enzyme-free and isothermal hybridization chain reaction with SYBR Green and graphene oxide (GOX) for early detection of miR-137 and miR-142, as two Alzheimer's biomarkers. +genetics_overexpression_promote 31833387 hsa-mir-150 Liver Cirrhosis 5p overexpression promoted HSC apoptosis and sensitized hepatocyte apoptosis; miR +tissue_expression_up 31833346 hsa-mir-155 Epstein-Barr Virus Infections Also when we evaluated the mir-155 expression levels comparing all EBV negative patients with an active EBV infection, we did not observe a statistical significant difference ( p=0.9782). +epigenetics 31833222 hsa-mir-378 Myelodysplastic Syndromes CONCLUSION: Hypomethylation of MIR-378 5'-flanking region is an adverse prognosticator in MDS, particularly in patients <60 years. +genetics_overexpression_suppress 31833046 hsa-mir-1294 Stomach Neoplasms In addition, miR-1294 regulates epithelial-mesenchymal transition (EMT) by inhibiting FOXK1 in GC cells and it can be rescued by overexpression of FOXK1. +circulation_biomarker_diagnosis_up 31833019 hsa-mir-135a Diabetes Mellitus, Type 2 Multinomial logistic regression and ROC curve analysis were conducted to assess the diagnostic accuracy of plasma miR-135a in T2D , prediabetes, and healthy control groups. +other 31832755 hsa-mir-186 Corneal dystrophy, epithelial basement membrane Especially, miR-151a and miR-186 were more abundant in BM and GCB than in GCF and GJ. Our study is the first to elucidate the human GJ miRNA profile and demonstrate the possibility that miR-151a and miR-186 in GC may be the biomarker of breast-feeding. +other 31832755 hsa-mir-151a Corneal dystrophy, epithelial basement membrane Especially, miR-151a and miR-186 were more abundant in BM and GCB than in GCF and GJ. Our study is the first to elucidate the human GJ miRNA profile and demonstrate the possibility that miR-151a and miR-186 in GC may be the biomarker of breast-feeding. +lncRNA target 31832575 hsa-mir-10a Hepatitis C, Chronic Conclusion: MiRNA-10a is involved in abnormal liver metabolism in cirrhotic liver through down-regulation of the expression of the circadian rhythm gene Bmal1. +other 31832574 hsa-let-7a Cholestasis Conclusion: These studies demonstrate that miR-let7a-5p is involved in regulating ABCC2/Abcc2 expression, and is aberrantly up-regulated in obstructive cholestasis. +other 31832520 hsa-mir-124 Brain Ischemia The role of rno-miR3p in regulating MCT1 was as a positive regulator after 6 h of pMCAO, while a negative regulator after 24 h of pMCAO, however, both activities had protective effects against cerebral ischemia. +lncRNA target 31832068 hsa-mir-7 Carcinoma, Non-Small-Cell Lung 5p suppresses NSCLC metastasis. +lncRNA target 31832017 hsa-mir-182 Uterine Cervical Neoplasms FBXW11 axis play an important role in CC progression, and indicated a promising therapeutic target for CC patients. +lncRNA target 31832002 hsa-mir-760 Stomach Neoplasms We also found that upregulation of GIT1 weakened the inhibitory effect of miR-760 in GC. +transcription factor target 31831830 hsa-mir-204 Colorectal Neoplasms 3p and consequent suppression of the alphaV/beta3-integrin/FAK axis. +circulation_biomarker_diagnosis_up 31831773 hsa-mir-127 Femur Head Necrosis 5p were upregulated in serum and bone samples from the AIONFH patients compared to those from the normal control individuals (p < 0.01). +circulation_biomarker_diagnosis_up 31831773 hsa-mir-1 Femur Head Necrosis 5p were upregulated in serum and bone samples from the AIONFH patients compared to those from the normal control individuals (p < 0.01). +circulation_biomarker_diagnosis_up 31831773 hsa-mir-885 Femur Head Necrosis 5p were upregulated in serum and bone samples from the AIONFH patients compared to those from the normal control individuals (p < 0.01). +circulation_biomarker_diagnosis_up 31831773 hsa-mir-628 Femur Head Necrosis 5p were upregulated in serum and bone samples from the AIONFH patients compared to those from the normal control individuals (p < 0.01). +circulation_biomarker_diagnosis_up 31831773 hsa-mir-483 Femur Head Necrosis 5p were upregulated in serum and bone samples from the AIONFH patients compared to those from the normal control individuals (p < 0.01). +circRNA target 31831728 hsa-mir-20a Uterine Cervical Neoplasms In addition, FoxM1 promoted cell proliferation, migration, and invasion of cervical cancer, while miR-320a suppressed cell proliferation, migration, and invasion through suppressing FoxM1, and circCLK3 enhanced cell proliferation, migration and invasion through sponging miR-320a and promoting FoxM1 expression. +lncRNA target 31831299 hsa-mir-4262 Glioma Inhibition of miR-4262 in glioma cancer cells prominently inhibited cell proliferation and migration. +lncRNA target 31831175 hsa-mir-77 Osteoarthritis 3p may be a therapeutic target in OA. +lncRNA target 31831175 hsa-mir-77 Cartilage Diseases 3p may be a therapeutic target in OA. +other 31831137 hsa-mir-16 Inflammation Here we show that incubation of B cells from young lean individuals with leptin increases the frequencies of pro-inflammatory B cells and induces intrinsic B cell inflammation, characterized by mRNA expression of pro-inflammatory cytokines (TNF-alpha and IL-6), chemokines (IL-8), micro-RNAs (miR-155 and miR-16), TLR4 and p16, a cell cycle regulator associated with immunosenescence. +other 31831137 hsa-mir-16 Immune System Diseases Here we show that incubation of B cells from young lean individuals with leptin increases the frequencies of pro-inflammatory B cells and induces intrinsic B cell inflammation, characterized by mRNA expression of pro-inflammatory cytokines (TNF-alpha and IL-6), chemokines (IL-8), micro-RNAs (miR-155 and miR-16), TLR4 and p16, a cell cycle regulator associated with immunosenescence. +other 31831137 hsa-mir-155 Inflammation Here we show that incubation of B cells from young lean individuals with leptin increases the frequencies of pro-inflammatory B cells and induces intrinsic B cell inflammation, characterized by mRNA expression of pro-inflammatory cytokines (TNF-alpha and IL-6), chemokines (IL-8), micro-RNAs (miR-155 and miR-16), TLR4 and p16, a cell cycle regulator associated with immunosenescence. +other 31831137 hsa-mir-155 Immune System Diseases Here we show that incubation of B cells from young lean individuals with leptin increases the frequencies of pro-inflammatory B cells and induces intrinsic B cell inflammation, characterized by mRNA expression of pro-inflammatory cytokines (TNF-alpha and IL-6), chemokines (IL-8), micro-RNAs (miR-155 and miR-16), TLR4 and p16, a cell cycle regulator associated with immunosenescence. +lncRNA target 31831099 hsa-mir-101 Squamous Cell Carcinoma of Head and Neck Dual-luciferase reporter assay confirmed that miR-101 directly targeted transforming growth factor-beta receptor 1 (TGF-betaR1) in OSCC. +lncRNA target 31831098 hsa-mir-15b Pituitary Neoplasms We report that RPSAP52, interacting with the RNA binding protein HuR (human antigen R), favors the delocalization of miR-15a, miR-15b, and miR-16 on the cyclin-dependent kinase inhibitor p21Waf1/CIP1 that, accordingly, results in downregulation in pituitary adenomas. +lncRNA target 31831098 hsa-mir-16 Pituitary Neoplasms We report that RPSAP52, interacting with the RNA binding protein HuR (human antigen R), favors the delocalization of miR-15a, miR-15b, and miR-16 on the cyclin-dependent kinase inhibitor p21Waf1/CIP1 that, accordingly, results in downregulation in pituitary adenomas. +lncRNA target 31831098 hsa-mir-15a Pituitary Neoplasms We report that RPSAP52, interacting with the RNA binding protein HuR (human antigen R), favors the delocalization of miR-15a, miR-15b, and miR-16 on the cyclin-dependent kinase inhibitor p21Waf1/CIP1 that, accordingly, results in downregulation in pituitary adenomas. +lncRNA target 31830901 hsa-mir-138 Pancreatic Carcinoma CONCLUSION: MCM3AP-AS1 promoted growth and migration through modulating miR +genetics_GWAS 31830533 hsa-mir-34a Leukemia, Myeloid, Acute ANRIL knockdown inhibited cell proliferation, migration and invasion but promoted apoptosis of AML cells, while overexpression of miR-34a exerted opposite effects. +lncRNA target 31830514 hsa-mir-210 Carcinoma, Non-Small-Cell Lung In the present study, we aimed to clarify the biomarker roles of miR-210 in NSCLC through a comprehensive meta-analysis and an integrative bioinformatics analysis. +transcription factor target 31830337 hsa-mir-873 Colorectal Neoplasms TNNT1 was identified as a target gene of miR-873, and there was a negative correlation among CRC samples. CONCLUSIONS: In conclusion, we have demonstrated that TNNT1, regulated by miR-873, is an oncogene of CRC associated with patient prognosis. +lncRNA target 31830266 hsa-mir-218 Diabetic Retinopathy CONCLUSION: Our findings suggest the miR-218/Runx2 axis as a potential target for treating diabetic retinopathy (DR). +lncRNA target 31830266 hsa-mir-218 Cone Dystrophy 3 RESULTS: Our results showed that glucose up-regulated miR-218 expression, suppressed proliferation, and induced the apoptosis of ARPE-19 cells. +lncRNA target 31830266 hsa-mir-218 Duane Retraction Syndrome CONCLUSION: Our findings suggest the miR-218/Runx2 axis as a potential target for treating diabetic retinopathy (DR). +lncRNA target 31829474 hsa-mir-585 Stomach Neoplasms Collectively, these results suggested that LINC01436 was an oncogenic lncRNA in GC and promoted proliferation and metastasis of GC cell via regulating miR-585 and FBOX11. +lncRNA target 31829323 hsa-mir-29a Cardiovascular Diseases Detection of miR-29a, a microRNA associated with myocardial infarction, was achieved at a level of pg muL-1 through the combination of three-dimensional paper-based microfluidics, colorimetric detection, and surface enhanced Raman scattering (SERS) analysis. +other 31829310 hsa-mir-124 Carcinoma miR-124 was reported to involve in the icaritin-induced mitochondrial apoptosis in human carcinoma cells. +transcription factor target 31829310 hsa-mir-10a Lung Neoplasms In the present study, realtime-PCR results showed that miR-10a was significantly down-regulated after icaritin treatment in human non-small cell lung cancer cells (A549). Taken together, miR-10a targets PTEN to mediate the anti-tumor effect of icaritin in A549 cells, which provides a novel insight into the anti-tumor mechanism of icaritin and may provide a new strategy for lung cancer therapy. +other 31829310 hsa-mir-10a Carcinoma, Non-Small-Cell Lung In the present study, realtime-PCR results showed that miR-10a was significantly down-regulated after icaritin treatment in human non-small cell lung cancer cells (A549). +lncRNA target 31829305 hsa-mir-145 Ovarian Neoplasms Functionally, LncRNA-ROR could induce epithelial-mesenchymal transition (EMT), and regulated ovarian cancer cell migration and invasion by decreasing the expression of tumor suppressive miR-145 and its target gene FLNB. Taken together, LncRNA-ROR promoted EMT by the miR-145/FLNB regulatory axis in ovarian cancer, providing a potential therapeutic target for ovarian cancer. +genetics_overexpression_promote 31829261 hsa-mir-624 Osteosarcoma 5p expression was upregulated in OS cells and tissues, and overexpressing miR +other 31829247 hsa-mir-150 Lupus Nephritis CONCLUSIONS: LNA-anti-miR-150 may be a promising novel therapeutic agent for LN in addition to the current emerging monoclonal antibodies, and its renal protective mechanism may be mediated by anti-fibrosis and anti-inflammation as well as reduction of the infiltrated kidney resident macrophages. +other 31829247 hsa-mir-150 Diabetic Nephropathies CONCLUSIONS: LNA-anti-miR-150 may be a promising novel therapeutic agent for LN in addition to the current emerging monoclonal antibodies, and its renal protective mechanism may be mediated by anti-fibrosis and anti-inflammation as well as reduction of the infiltrated kidney resident macrophages. +lncRNA target 31829167 hsa-mir-20 Burns METHODS: Anesthetized rats were subjected to 40% total body surface area water burn immediately, followed by treatment with ED, scrambled antagomir, or antagomiR-320. CONCLUSION: ED regulates Akt/Bad/Caspase signaling cascade to reduce apoptosis and oxidative stress through up-regulating miR-320 expression and down-regulating PTEN expression, thus protecting the intestinal mucosal barrier of rats from burn injury. +lncRNA target 31829105 hsa-mir-222 Lymphoma, Large B-Cell, Diffuse 3p promoted the proliferation and invasion and inhibited the apoptosis of activated B cell-like-type diffuse large B-cell lymphoma cells through suppressing phosphatase 2 regulatory subunit B alpha expression. +transcription factor target 31829025 hsa-mir-378a Squamous Cell Carcinoma of Head and Neck To sum up, our study suggests that miR-378a-5p suppressed angiogenesis of OSCC at least partly by the regulation of KLK4. +other 31828982 hsa-mir-144 Cachexia 5p (FC = 0.59), and miR-451a (FC = 0.57). +other 31828982 hsa-mir-451a Cachexia 5p (FC = 0.59), and miR-451a (FC = 0.57). +other 31828982 hsa-mir-450a Cachexia 5p (FC = 0.59), and miR-451a (FC = 0.57). +transcription factor target 31828873 hsa-mir-124a Teratoma We demonstrated that ectopic expression of miR-124a in teratomas by intratumor delivery of miR-124a mimic and Atelocollagen, significantly suppressed endoderm and mesoderm lineage differentiation while augmenting the differentiation into ectoderm lineage. +other 31828562 hsa-mir-4731 Lichen Planus, Oral The increased expression of MAPK/ERK1/2 and decreased expression of miR-603 and miR-4731 are associated with greater risk of OLP malignant transformation and poor histopathological characteristics of OSCC. +genetics_overexpression_promote 31828417 hsa-mir-1207 Melanoma 5p overexpression suppressed melanoma cell growth and cell mobility. +genetics_overexpression_promote 31828293 hsa-mir-122 Stomach Neoplasms Importantly, overexpression of LYN restored miR +circulation_biomarker_diagnosis_ns 31828273 hsa-mir-34a Breast Neoplasms Conclusion: MicroRNA-34a expression is significantly decreased in the patients' serum with the cancer of breast, and miRNA-34a can be employed as a potential non-invasive molecular marker for the early diagnosis of BC. +other 31828143 hsa-mir-219 Carcinoma, Hepatocellular SMC4 regulatory pathway under hypoxic condition in HCC cells. +transcription factor target 31828133 hsa-mir-221 Obesity miR-221 may be a novel target for preventing and treating obesity-induced insulin resistance. +transcription factor target 31828111 hsa-mir-221 Prostatic Neoplasms By using proliferation and apoptosis assays, we show a novel feature of miR-221 in PCa cells: instead of inducing TRAIL resistance, miR-221 sensitized cells towards TRAIL-induced proliferation inhibition and apoptosis induction. +other 31827704 hsa-mir-199 Reperfusion Injury, Hepatic Ischemia Our data indicate that AK054386 and miR-199 are critical players in hepatic IRI, and we broadened the scope regarding ceRNA mechanisms. +other 31827490 hsa-let-7f-1 Atherosclerosis 5p, -99a-3p, and -6087) and 14 genes (AK5, CD248, CDS2, FAM129A, FBLN2, GGT1, NOG, NRCAM, PDE7A, RP11-545E17.3, SLC12A2, SLC16A10, SLC4A10, and ZSCAN18) were the most significantly differentially expressed in LEAD group compared to controls. +other 31827490 hsa-mir-34a Atherosclerosis 5p, -99a-3p, and -6087) and 14 genes (AK5, CD248, CDS2, FAM129A, FBLN2, GGT1, NOG, NRCAM, PDE7A, RP11-545E17.3, SLC12A2, SLC16A10, SLC4A10, and ZSCAN18) were the most significantly differentially expressed in LEAD group compared to controls. +lncRNA target 31827402 hsa-mir-17 Prostatic Neoplasms 5p axis, and circITCH have a potential usage as therapeutic target for PC tumors. +other 31827401 hsa-mir-141 Urinary Bladder Neoplasms In total, 5 lncRNAs (HCG22, ADAMTS9-AS1, ADAMTS9-AS2, AC078778.1, and AC112721.1), 2 miRNAs (hsa-mir-145 and hsa-mir-141) and 6 mRNAs (ZEB1, TMEM100, MAP1B, DUSP2, JUN, and AIFM3) were found to be related to OS. +genetics_overexpression_promote 31827400 hsa-mir-135a Osteosarcoma RESULTS: Overexpressed ZFAS1 and APEX1, and down-regulated miR-135a existed in OS tissues and cells. +genetics_knock down_promote 31827399 hsa-mir-145 Urinary Bladder Neoplasms 5p inhibition and PCBP2 up-regulation could countervail the tumor-inhibitor role of KCNQ1OT1 knockdown in BC. +exosome 31827397 hsa-mir-34b Uterine Cervical Neoplasms Exosomes shuttled HNF1A-AS1 promoted the proliferation and drug resistance of CC cells and inhibited their apoptosis by upregulating the expression of TUFT1 and downregulating miR-34b. +genetics_knock down_promote 31827394 hsa-mir-2682 Pancreatic Carcinoma 5p inhibition or HOXB8 overexpression countervailed the repressive role of LINC01006 downregulation in PC cell progression. +lncRNA target 31827393 hsa-mir-135a Squamous Cell Carcinoma of Head and Neck Silencing KLF8 using its specific siRNA showed that KLF8 was responsible for the induction of miR-135a-5p inhibitor on TSCC cell malignancies and MMP-2/9 expression. +lncRNA target 31827393 hsa-mir-135 Squamous Cell Carcinoma of Head and Neck Silencing KLF8 using its specific siRNA showed that KLF8 was responsible for the induction of miR-135a-5p inhibitor on TSCC cell malignancies and MMP-2/9 expression. +circulation_biomarker_diagnosis_ns 31827380 hsa-mir-6803 Colorectal Neoplasms 5p and PTPRO mRNA in peripheral blood mononuclear cells of CRC patients is estimated by real-time PCR. +transcription factor target 31827329 hsa-mir-18a Carcinoma, Hepatocellular In addition, RP5-833A20.1 could suppress the tumorigenesis in HCC through inhibiting Akt/ERK pathway by acting as a ceRNA for miR-18a-5p. +genetics_overexpression_promote 31827328 hsa-mir-183 Retinoblastoma Moreover, overexpressed NRAS reversed miR +circulation_biomarker_diagnosis_ns 31827152 hsa-mir-146a Acquired Immunodeficiency Syndrome In this study, we investigated peripheral blood mononuclear cells (PBMCs) exhaustion markers from 109 chronic HIV +circulation_biomarker_diagnosis_ns 31827150 hsa-mir-27a Non-alcoholic Fatty Liver Disease Serum miR-20a and miR-27a levels were significantly lower in both male and female severe NAFLD subjects. +other 31827114 hsa-mir-200 Breast Neoplasms MYB signaling. +other 31827114 hsa-mir-200b Breast Neoplasms We report here elevated levels of EMT markers (vimentin and ZEB1/2) and reduced levels of EMT-regulating miR-200 (miR-200b and miR-200c) in ER-positive breast cancer cells, MCF-7, that were resistant to tamoxifen, in contrast with the naive parental MCF-7 cells that were sensitive to tamoxifen. Forced over-expression of miR-200b/c reduced c-MYB whereas reduced expression of miR-200b/c resulted in increased c-MYB We further confirmed the results in other ER-positive breast cancer cells T47D cells where forced over-expression of c-MYB resulted in induction of EMT and significantly increased resistance to tamoxifen. +exosome 31826604 hsa-mir-223 Hepatitis, Autoimmune These results suggest that MSC-exosomes can be used to deliver miR +exosome 31826179 hsa-mir-29b Spinal Cord Injuries The relieving degree of SCI was significantly higher in the miRNA-29b exosomes group than in the miRNA-29b BMSCs group (P<0.05). +lncRNA target 31825987 hsa-mir-21 De Lange Syndrome Further, decrease of miR 21 in SL, by means of transfection with a miR 21 inhibitor, increased the IL-12 cytokine and the T-bet/GATA-3 ratio, and decreased parasite load on SL of dogs with CanL. +lncRNA target 31825829 hsa-let-7 Glioma In human and murine glioblastoma/glioma, let-7 miRNAs are differentially expressed and reduce murine GL261 glioma growth in the same sequence-specific fashion through microglial TLR7. Taken together, these data establish let-7 miRNAs as key TLR7 signaling activators that serve to regulate the diverse functions of microglia in health and glioma. +lncRNA target 31825519 hsa-mir-539 Sepsis 5p alleviated sepsis-induced ALI via suppressing its downstream target ROCK1, suggesting a therapeutic potential of miR +lncRNA target 31825519 hsa-mir-539 Acute Lung Injury 5p alleviated sepsis-induced ALI via suppressing its downstream target ROCK1, suggesting a therapeutic potential of miR +other 31824846 hsa-mir-129 Carcinoma, Renal Cell Our findings demonstrated that SNHG12 served as a sponge for miR5p to regulate the expression of MDM4 and p53 pathway in the development of ccRCC. +transcription factor target 31824844 hsa-mir-4666 Colorectal Neoplasms Furthermore, we find miR3p could also target TGF-betaR1 to block the activation of TGF-beta1/Smad pathway, therefore function as a tumor suppressor gene to inhibit the stemness of colon cancer cells. +other 31824844 hsa-mir-29 Colorectal Neoplasms Finally, we evaluate the expression of both miR3p and miR-329 in 73 tumor specimens and paired normal tissue, and find both two miRNAs are related to unfavorable prognosis and advanced tumor stage in colorectal cancer. +transcription factor target 31824836 hsa-mir-9 Glioblastoma 5p can inhibit glioma cells proliferation by downregulating FOXP2. +other 31824476 hsa-mir-378a Inflammatory Bowel Diseases Together, our results propose a regulatory mechanism of IL-33 expression exerted by miR-378a-3p in an inflammatory environment, contributing to the understanding of UC pathogenesis. +other 31824476 hsa-mir-378 Inflammatory Bowel Diseases Together, our results propose a regulatory mechanism of IL-33 expression exerted by miR-378a-3p in an inflammatory environment, contributing to the understanding of UC pathogenesis. +genetics_overexpression_promote 31824193 hsa-mir-194 Colonic Neoplasms Furthermore, overexpression of miR-194 resulted in blocking the G1/S transition, the induction of cellular apoptotic process, thereby suppressing the malignant behaviors of CRC stem cells. +genetics_knock down_suppress 31824174 hsa-mir-6754 Breast Neoplasms Moreover, overexpression of LYPD1 can rescue the migration and invasion abilities of breast cancer cells decreased by knockdown of HULC or overexpression of miR +other 31823896 hsa-mir-124 Depression These findings indicate that during chronic unpredictable mild stress-induced depression, the behavioral phenotype, miR-124 expression in the hippocampus, neurogenesis in thedentate gyrus and neuronal numbers showed dynamic changes, which suggested that various pathological changes occur at different stages of depression. +other 31823788 hsa-mir-143 Lung Neoplasms 3p/VASH1 axis in BM of lung cancers and suggests their critical roles in lung cancer pathogenesis. +lncRNA target 31823782 hsa-mir-595 Thyroid Cancer, Papillary We previously demonstrated that IL-22 promotes PTC cell migration and invasion through the microRNA-595/Sox17 axis. +lncRNA target 31823748 hsa-mir-762 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: Our findings provide a rationale for future efforts testing miR-762 inhibition and ABR restoration co-treatment in patients with recurrent EGFR mutant NSCLC to therapeutically combat the heterogeneity of EGFR-TKIs resistance mechanisms. +genetics_knock down_promote 31823726 hsa-mir-380 Autoimmune Lymphoproliferative Syndrome 3p overexpression and knockdown, respectively, in alpaca melanocytes decreased and increased the mRNA levels of melanin transfer-related genes, including microphthalmia-associated transcription factor (MITF), tyrosinase (TYR), tyrosine-related protein-1 (TYRP1), and dopachrome tautomerase (DCT). +genetics_knock down_promote 31823518 hsa-mir-338 Carcinoma, Non-Small-Cell Lung Besides, knockdown of NFATc1 had the similar effects with miR-338 overexpression on NSCLC cells. +other 31822940 hsa-mir-137 Reperfusion Injury Here, we found that miR3p, a mature form of miR-137, was up-regulated in I/R-injured cardiomyocytes of myocardial infarction patients. +other 31822654 hsa-mir-516a Carcinoma, Hepatocellular We revealed that circ_0001955, TRAF6 and MAPK11 levels were increased, while miR-516a-5p levels were decreased in HCC tumor tissues compared to adjacent normal tissues. In conclusion, circ_0001955 facilitated HCC tumorigenesis by sponging miR-516a-5p to release TRAF6 and MAPK11 expression. +genetics_overexpression_promote 31822638 hsa-mir-9 Stomach Neoplasms In the primary human GC cells, forced LINC00682 overexpression similarly induced miR-9 downregulation and LMX1A upregulation, causing proliferation inhibition and apoptosis activation. +genetics_overexpression_promote 31822496 hsa-mir-223 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Furthermore, overexpression of the ARRB1-derived miR-223 sponge suppressed T-ALL cell proliferation and induced apoptosis. +genetics_overexpression_promote 31822249 hsa-mir-126 Infarction, Middle Cerebral Artery 3p and -5p overexpression reduced the expression of proinflammatory cytokines and adhesion molecules, and attenuated BBB disruption after ischemic stroke, suggesting that miR +genetics_overexpression_promote 31822000 hsa-mir-1231 Prostatic Neoplasms Additionally, we found overexpression of miR-1231 suppressed proliferation, migration, and invasion of prostate cancer cell linesin vitro. +lncRNA target 31821848 hsa-mir-380 Pulmonary Disease, Chronic Obstructive CONCLUSIONS: Depletion of miR-380 alleviated cells damage caused by CSE through targeting CHRNA4, suggesting that miR-380/CHRNA4 may serve as novel therapeutic targets for COPD treatment. +other 31821687 hsa-mir-7 Myofibroblasts Therefore, NETs promote PM-related ILD, and TLR9-miRSmad2 signalling pathway is involved in the proliferation of LFs and their differentiation into MFs. +other 31821602 hsa-mir-125a Asthma CONCLUSION: LncRNA ANRIL/miR-125a is potentially indicative of disease exacerbation, exacerbation severity, and inflammation for bronchial asthma, while these findings are preliminary and need further confirmation. +lncRNA target 31821542 hsa-mir-145 Ovarian Neoplasms In summary, our findings suggest that the miR-145/c-Myc/PD-L1 axis contributes to cisplatin resistance in ovarian cancer and support that miR-145 might act as an adjuvant therapeutic target in chemotherapy of ovarian cancer. +other 31821171 hsa-mir-636 Urinary Bladder Neoplasms Cell transfection experiments showed that miR-636 promotes the proliferation of BC cells by decreasing the expression of Kruppel Like Factor 9 (KLF9) upon binding to the 3'UTR of its mRNA.Further analysis confirmed that circPTPRA competitively sponges miR-636 to upregulate the KLF9 expression, leading to decreased proliferation of BC cells. +circulation_biomarker_diagnosis_ns 31821038 hsa-mir-130b Diabetes Mellitus miR-130b is a microRNA whose expression is particularly elevated within adipose tissue and in the circulation in diabetic states. +other 31821038 hsa-mir-130b Carcinoma, Hepatocellular Hepatic miR-130b expression has been linked to hepatocellular carcinoma and changes in lipid metabolism. +lncRNA target 31820783 hsa-mir-154 Thyroid Neoplasms 3p/487-3p may be a valuable therapeutic target for impeding thyroid cancer progression. +transcription factor target 31820686 hsa-mir-205 Pulmonary Fibrosis OBJECTIVE: To investigate the role of miR-205 and GATA3 in Pulmonary Fibrosis (PF). CONCLUSION: miR-205 improved pulmonary fibrosis through inhibiting ER-stress by targeting GATA3. +circulation_biomarker_diagnosis_ns 31820498 hsa-mir-125a psoriasis 1 Measurement of circulating miR-125a exhibits good value in the management of ETN-treated psoriatic patients. +other 31820187 hsa-mir-214 Cardiovascular Diseases miR-214 was reported to contribute to the pathogenesis of cardiovascular diseases, while its role in IS-induced endothelial cell apoptosis is unknown. +lncRNA target 31819647 hsa-mir-520a Stomach Neoplasms CONCLUSION: Our study provided the first evidence for the existence of HIF1alpha/miR-520a-3p/AKT1/mTOR feedback, which promotes the proliferation and glycolysis of GC cells, highlighting a potential novel target for treatment. +other 31819644 hsa-mir-125a Carcinoma, Endometrioid CONCLUSION: MiR143HG may up-regulate p53 in EC by sponging miR-125a to promote cancer cell apoptosis. +other 31819644 hsa-mir-143 Carcinoma, Endometrioid This study was therefore carried out to explore the interaction between miR143HG and miR-125a in endometrial carcinoma (EC). +genetics_overexpression_promote 31819598 hsa-mir-138 Sciatic Neuropathy CONCLUSION: The results indicate that miR138 contributes to the development of neuropathic pain and that the overexpression of miR138 alleviates pain hypersensitivity by inhibiting proinflammatory cytokine production and glial activation, which suggests a novel target for reducing neuropathic pain. +genetics_overexpression_promote 31819598 hsa-mir-138 Neuralgia CONCLUSION: The results indicate that miR138 contributes to the development of neuropathic pain and that the overexpression of miR138 alleviates pain hypersensitivity by inhibiting proinflammatory cytokine production and glial activation, which suggests a novel target for reducing neuropathic pain. +lncRNA target 31819532 hsa-mir-509 Testicular Germ Cell Tumor 5p suppresses TGCT cells through targeting MDM2. +lncRNA target 31819532 hsa-mir-509 Infertility, Male 5p suppresses TGCT cells through targeting MDM2. +genetics_overexpression_promote 31819525 hsa-mir-424 Squamous Cell Carcinoma of Head and Neck Overexpression of miR +lncRNA target 31819522 hsa-let-7b Carcinoma, Hepatocellular CONCLUSION: The over-expression of NEAT1 could promote the proliferation of HCC cells by inhibiting the expression of the miR-let-7b regulated by IGF-1R. +lncRNA target 31819520 hsa-mir-370 Leukemia, Myeloid, Acute CONCLUSION: TUG1 could modulate malignant phenotypes of AML cells via miR3p/MAPK1/ERK signaling. +lncRNA target 31819516 hsa-mir-618 Stomach Neoplasms miR-618 inhibited GC progression and PI3K/ATK signaling pathway by targeting KLF12. +genetics_overexpression_promote 31819515 hsa-mir-99a Colorectal Neoplasms In addition, miR-99a overexpression remarkably impaired CRC cell proliferation and metastasis, and negatively regulated mTOR signaling through direct binding to the 3'-UTR of mTOR. +genetics_overexpression_promote 31819515 hsa-mir-99a Diabetes Mellitus In addition, miR-99a overexpression remarkably impaired CRC cell proliferation and metastasis, and negatively regulated mTOR signaling through direct binding to the 3'-UTR of mTOR. +lncRNA target 31819510 hsa-mir-188 Retinoblastoma 5p promoted EMT by targeting ID4 through Wnt/beta catenin signaling in Rb. +other 31819505 hsa-mir-1200 Glioma CONCLUSION: Collectively, our work clarified that RGMB-AS1/miR-1200/HOXB2 signaling exerts an essential role in regulating glioma progression. +genetics_overexpression_promote 31819503 hsa-mir-193b Osteosarcoma miR-193b overexpression in the OS cell lines induced autophagy and apoptosis, as shown by Western blotting and flow cytometry. +genetics_overexpression_promote 31819495 hsa-mir-149 Chordoma 3p overexpression in U-CH1 and MUG-Chor1 cells. +lncRNA target 31819494 hsa-mir-124 Melanoma Furthermore, the results of functional experiments showed that degradation of RACK1 by miR-124 inhibited proliferation, migration, and invasion of melanoma cells, and promoted melanoma cell apoptosis. +circRNA target 31819492 hsa-mir-361 Uterine Cervical Neoplasms 3p expression, which provided a novel therapeutic target for the treatment of CC patients. +lncRNA target 31819489 hsa-mir-143 Carcinoma, Non-Small-Cell Lung 3p/RRM2 signal pathway that played an important role in the progress of NSCLC, which might be potential therapeutic targets for NSCLC. +genetics_knock down_promote 31819485 hsa-mir-494 Medulloblastoma 3p inhibitor abolished the effects of TP73-AS1 knockdown on medulloblastoma cells. +lncRNA target 31819483 hsa-mir-543 Carcinoma, Non-Small-Cell Lung Moreover, THUMPD3-AS1 may act as an endogenous sponge of microRNA-543 (miR-543) which can regulate the target gene ONECUT2 in NSCLC cells. CONCLUSION: Our study indicated that THUMPD3-AS1 regulated NSCLC cell self-renewal by regulating the expression of miR-543 and ONECUT2, and THUMPD3-AS1 can potentially act as a biomarker or therapeutic target in NSCLC. +genetics_knock down_promote 31819476 hsa-mir-214 Endometrial Neoplasms 3p in EC cells, and its overexpression significantly restored the inhibitory effects of miR +lncRNA target 31819474 hsa-mir-625 Nasopharyngeal Carcinoma NUAK1 pathway might be a target for anticancer therapy in patients with NPC. +genetics_GWAS 31819463 hsa-mir-922 Ischemic Stroke CONCLUSION: Our study demonstrates that the SNP rs7124442 in BDNF 3'-UTR, through affecting the regulatory role of miR-922 in BDNF expression, might act as a protective factor for the outcome of patients with ischemic stroke. +other 31819394 hsa-mir-92b Pseudomonas Infections Both miR-92b-5p and miR3p could discriminate PA colonization (C-statistic >0.60) and independently correlated with PA colonization in multiple linear regression analysis. +other 31819394 hsa-mir-223 Pseudomonas Infections Both miR-92b-5p and miR3p could discriminate PA colonization (C-statistic >0.60) and independently correlated with PA colonization in multiple linear regression analysis. +transcription factor target 31819204 hsa-mir-204 Cervical Spondylomyelopathy Hence, we performed this study to investigate the potential role of miR-204 in the neuropathic pain of cervical spondylotic radiculopathy (CSR) by targeting GDNF. Taken together, upregulation of GDNF induced by miR-204 silencing confers protection against SCC-induced pain in rat models, suggesting a potential therapeutic target for CSR treatment. +lncRNA target 31819178 hsa-mir-137 Squamous Cell Carcinoma of Head and Neck Using both in vivo and in vitro models, we found that knocking down ASCT2 by shRNAs or miR-137 or the combination of silencing ASCT2 and pharmacologically inhibiting SNAT2 via a small-molecule antagonist called V-9302 significantly suppressed intracellular glutamine levels and downstream glutamine metabolism, including glutathione production; these effects attenuated growth and proliferation, increased apoptosis and autophagy, and increased oxidative stress and mTORC1 pathway suppression in HNSCC. +transcription factor target 31819170 hsa-mir-155 Pulmonary Disease, Chronic Obstructive In conclusion, we highlight a role for miR-155 in CS-induced inflammation and the pathogenesis of COPD, implicating miR-155 as a new therapeutic target in COPD. +transcription factor target 31819170 hsa-mir-155 Pneumonia In conclusion, we highlight a role for miR-155 in CS-induced inflammation and the pathogenesis of COPD, implicating miR-155 as a new therapeutic target in COPD. +circRNA target 31818066 hsa-mir-566 Adenocarcinoma of Lung Conclusions: The hsa_circ_0014130 promotes the invasion and proliferation of lung cancer cells by targeting hsa-miR-566 to enhance the expression of TWIST1, and its expression level can be significantly inhibited by the small molecule inhibitor SB-431542, which significantly inhibits the proliferation and invasion of lung cancer cells. +other 31817907 hsa-mir-146a-1 Pica 5p) were shown by qPCR to be significantly induced by both pIC and ASAL. +other 31817907 hsa-mir-27d-1 Pica 5p) were shown by qPCR to be significantly induced by both pIC and ASAL. +other 31817907 hsa-mir-221 Pica 5p) were shown by qPCR to be significantly induced by both pIC and ASAL. +other 31817907 hsa-mir-221 Anemia, sideroblastic spinocerebellar ataxia 5p) were shown by qPCR to be significantly induced by both pIC and ASAL. +other 31817907 hsa-mir-29b-2 Pica 5p) were shown by qPCR to be significantly induced by both pIC and ASAL. +other 31817907 hsa-mir-27d-1 Anemia, sideroblastic spinocerebellar ataxia 5p) were shown by qPCR to be significantly induced by both pIC and ASAL. +other 31817907 hsa-mir-29b-2 Anemia, sideroblastic spinocerebellar ataxia 5p) were shown by qPCR to be significantly induced by both pIC and ASAL. +other 31817907 hsa-mir-146a-1 Anemia, sideroblastic spinocerebellar ataxia 2-3p, miR-192a-5p, miR-194a-5p) in the PBS- and ASAL-injected groups had significantly higher expression in CpG-fed fish. +circulation_biomarker_diagnosis_down 31817742 hsa-mir-22 Pulmonary Disease, Chronic Obstructive Serum miR +circulation_biomarker_diagnosis_down 31817673 hsa-mir-137 Triple Negative Breast Neoplasms Among the 30 TNBC specimens, miR-137 was downregulated and Del-1 level in plasma was significantly elevated relative to normal controls. +genetics_GWAS 31816923 hsa-mir-125b Carcinoma, Hepatocellular In this study, we evaluated a replacement strategy for the treatment of HCC via delivery of EVs secreted from human adipose tissue-derived mesenchymal stromal/medicinal signaling cells (ASCs) genetically modified with a lentiviral vector expressing miR-125b with a specific ExoMotif sequence tag to enhance the loading into extracellular vesicles. +other 31816052 hsa-mir-221 Gaucher Disease We also show that in Gba mutant fish a miR-221 upregulation is associated with reduced dvl2 expression levels and that in type I Gaucher patients single-nucleotide variants in the DVL2 3' untranslated region are related to variable canonical Wnt pathway activity. +circulation_biomarker_diagnosis_ns 31815867 hsa-mir-129 Heart Failure Real-time PCR (RT-PCR) was used to determine the relative RNA expression of NEAT1 and its potential target microRNA, miR5p, in the plasma of patients with acute myocardial infarction, heart failure, and angina, as well as in H2O2-treated H9c2 cells. +circulation_biomarker_diagnosis_ns 31815867 hsa-mir-129 Myocardial Infarction Real-time PCR (RT-PCR) was used to determine the relative RNA expression of NEAT1 and its potential target microRNA, miR5p, in the plasma of patients with acute myocardial infarction, heart failure, and angina, as well as in H2O2-treated H9c2 cells. +circulation_biomarker_diagnosis_ns 31815867 hsa-mir-129 Angina Pectoris Real-time PCR (RT-PCR) was used to determine the relative RNA expression of NEAT1 and its potential target microRNA, miR5p, in the plasma of patients with acute myocardial infarction, heart failure, and angina, as well as in H2O2-treated H9c2 cells. +lncRNA target 31815762 hsa-mir-21 Uterine Cervical Neoplasms Our data suggest that miR-21/Smad7 pathway may be an effective target for drug resistance in cervical cancer treatment. +lncRNA target 31815639 hsa-mir-552 Ovarian Neoplasms CONCLUSION: Our findings revealed that miR-552 could promote ovarian cancer cells progression by targeting PTEN signaling and might therefore be useful to predict patient prognosis. +other 31815358 hsa-mir-663 Burns The level of miR-486 and miR-663 was increased after burn injury, meanwhile, the highest level of miR-486 and miR-663 was found after lidocaine treatment. +other 31815358 hsa-mir-486 Burns The level of miR-486 and miR-663 was increased after burn injury, meanwhile, the highest level of miR-486 and miR-663 was found after lidocaine treatment. +genetics_overexpression_promote 31814920 hsa-mir-574 Uterine Cervical Neoplasms Finally, we indicated that PTCSC3 overexpression suppressed cervical carcinoma progression via regulating miR +genetics_overexpression_promote 31814906 hsa-mir-137 Inflammation Overexpression of miR-137 suppressed cell growth, extracellular matrix (ECM) degradation and inflammation in chondrocytes. These preliminary data elucidated that miR-137 suppressed OA progression via inhibiting cell growth, inflammation and ECM degradation. +genetics_knock down_promote 31814906 hsa-mir-137 Osteoarthritis However, the involvement and underlying mechanism of miR-137 in development of OA remains unkown. +other 31814906 hsa-mir-7 Osteoarthritis In our study, we firstly showed that IL-1beta decreased the expression of miR-137 in the chondrocytes and we demonstrated that the miR-37 expression level was lower in the OA cases than in the control patients. +lncRNA target 31814904 hsa-mir-376c Squamous Cell Carcinoma of Head and Neck Moreover, we showed that the expression level of miR-376c was lower in the LSCC samples than in the noncancerous tissues and the expression of miR-376c was negatively correlated with expression of DLX6-AS1 in LSCC tissues. Ectopic expression of miR-376c suppressed cell proliferation, cycle and invasion of LSCC cell. +lncRNA target 31814897 hsa-mir-181c Carcinoma, Hepatocellular Intriguingly, we further validated a direct interaction between miR-181c and SPP1, which indicated a post-transcriptional regulation mechanism of SPP1 in HCC. Thus, our results suggest that SPP1 may function as an enhancer of HCC growth targeted by miR-181c, and probably provide us an innovational target for HCC diagnose and therapeutic treatment. +genetics_overexpression_promote 31814890 hsa-mir-761 Thyroid Cancer, Papillary Furthermore, overexpression of lncRNA HOXA11-AS was inversely correlated with miR-761 expression in PTC tissues. +lncRNA target 31814886 hsa-mir-136 Thyroid Neoplasms 5p mimic and inhibitor were transfected into the TC B-CPAP cell, Thiazolyl Blue Tetrazolium Bromide (MTT) assay and cell apoptosis assay by FACS with Annexin V-/7-AAD double staining were performed to explore the biological role of miR +other 31814881 hsa-mir-185 Parkinson Disease The results suggested the protective role of miR-185 gene in preventing the development of PD. +other 31814850 hsa-mir-199a Thyroid Cancer, Papillary The expression levels of hsa-miR-199a-5p and decorin (DCN) were decreased in patients with PTC. The present study revealed that hsa-miR-199a-5p, DCN, CXCL12, LRP4 and CA12 may serve important roles in the pathogenesis of PTC. +transcription factor target 31814849 hsa-mir-15b Liver Neoplasms 3p and miR-15b-5p promote the proliferation and invasion of liver cancer cells through targeting axis formation inhibitor 2 (Axin2) and to identify suitable targets for the treatment of liver cancer. +transcription factor target 31814849 hsa-mir-221 Liver Neoplasms 3p and miR-15b-5p promote the proliferation and invasion of liver cancer cells through targeting axis formation inhibitor 2 (Axin2) and to identify suitable targets for the treatment of liver cancer. +genetics_overexpression_promote 31814848 hsa-mir-100 Colorectal Neoplasms In conclusion, the present study demonstrated that MIR100HG overexpression may contribute to the progression of CRC and may predict a poorer prognosis in patients with CRC. +other 31814833 hsa-mir-373 Myocardial Infarction miR-373 mimic itself was highly efficacious in preventing scar formation in the infarcted myocardium. +genetics_knock down_promote 31814765 hsa-mir-122 Carcinoma, Renal Cell CONCLUSION: Our findings revealed that overexpressed miR +genetics_knock down_suppress 31814763 hsa-mir-183 Stomach Neoplasms CONCLUSION: Taken together, hsa_circ_0000291 knockdown inhibited GC cell metastasis and growth by regulating the miR-183/ITGB1 axis. +genetics_knock down_promote 31814757 hsa-mir-203 Osteosarcoma In addition, miR-203 knockdown attenuated the tumor-suppressive effects of sevoflurane treatment on osteosarcoma cells. +transcription factor target 31814731 hsa-mir-32 Colorectal Neoplasms 5p enhanced the radiosensitivity and inhibited migration and invasion through promoting TOB1 expression. +other 31814565 hsa-mir-129 Liver Diseases, Alcoholic 5p expression is elevated in sigmoid colon biopsies and alcohol-induced differentiated Caco-2 cells from patients with alcoholic liver disease. +other 31814558 hsa-mir-486 Peripheral Blood Leukocytes 5p were considered as good candidates for obesity biomarkers. +other 31814558 hsa-mir-15b Peripheral Blood Leukocytes 5p were considered as good candidates for obesity biomarkers. +other 31814558 hsa-mir-122 Peripheral Blood Leukocytes 5p were considered as good candidates for obesity biomarkers. +other 31814558 hsa-mir-191 Peripheral Blood Leukocytes 5p. +other 31814558 hsa-mir-222 Peripheral Blood Leukocytes 5p. +lncRNA target 31814518 hsa-mir-34a Stomach Neoplasms The studies in vitro revealed that SNHG7 directly binds to miR-34a and negatively regulates miR-34a expression, and SNHG7 enhances gastric cancer cell migration and invasion through suppressing miR-34a-Snail-EMT axis. +exosome 31814034 hsa-mir-21 Urinary Bladder Neoplasms Moreover, it was found that miR21 was highly expressed in exosomes derived from bladder cancer cells as well as in macrophages treated with exosomes. +genetics_GWAS 31813598 hsa-mir-146a Graft vs Host Disease No significant association could be observed between miR-146a polymorphism and aGVHD. +lncRNA target 31813493 hsa-mir-384 Intraoperative Awareness The results suggest that miR5p can promote anesthesia damage to the abalone basal ganglia neurons in rats through a variety of biological processes and signaling pathways. +genetics_overexpression_promote 31813289 hsa-mir-21 Chondrosarcoma Besides, the overexpression of miR +genetics_overexpression_promote 31813135 hsa-mir-29b Carcinoma, Non-Small-Cell Lung Down-regulation of STRN4 inhibits NSCLC cells proliferation, migration, invasion, and promotes apoptosis in vitro, whereas overexpression-induced enhanced cell migration and invasion could be reverved by miR-29b. +other 31813125 hsa-mir-346 Epilepsy, Temporal Lobe 3p were significantly downregulated in EVs from the epileptic forebrain. +other 31813125 hsa-mir-31 Epilepsy, Temporal Lobe 3p were significantly downregulated in EVs from the epileptic forebrain. +lncRNA target 31812793 hsa-mir-211 Sepsis 3p and miR-211 herein, were both subjected to sponging of NEAT1, possibly affected inflammation responses in RAW264.7 cells, respectively, through modulating STAT3 and PI3K/AKT signaling. +lncRNA target 31812793 hsa-mir-495 Sepsis 3p and miR-211 herein, were both subjected to sponging of NEAT1, possibly affected inflammation responses in RAW264.7 cells, respectively, through modulating STAT3 and PI3K/AKT signaling. +lncRNA target 31812760 hsa-mir-504 Squamous Cell Carcinoma of Head and Neck The results of this study suggest that miR-504 may be a new therapeutic target for OSCC. +other 31812653 hsa-mir-499 Hypoxia-Ischemia, Brain 5p in the treatment of neonatal HIE. +lncRNA target 31812575 hsa-mir-218 Pulmonary Fibrosis Finally, microRNA 218-5p, which is downregulated in patients with IPF, suppressed 15-PGDH expression in vivo and in vitro. +other 31812104 hsa-mir-485 Uterine Cervical Neoplasms 5p/AMOTL1 as a promising novel therapeutic strategy for the treatment of this disease. +genetics_overexpression_promote 31812014 hsa-mir-574 Glioma 5p inhibitor/mimics in PSMB8-AS1 depletion/overexpression transfected glioma cells. +genetics_overexpression_promote 31811909 hsa-mir-877 Stomach Neoplasms Overexpression of miR +lncRNA target 31811872 hsa-mir-221 Parkinson Disease In conclusion, crocin showed promising neuroprotective effects in ROT-induced PD via activation of PI3K/Akt/mTOR axis and enhanced miRNA-7 and miRNA-221. +lncRNA target 31811872 hsa-mir-7 Parkinson Disease In conclusion, crocin showed promising neuroprotective effects in ROT-induced PD via activation of PI3K/Akt/mTOR axis and enhanced miRNA-7 and miRNA-221. +genetics_GWAS 31811586 hsa-mir-122 Ischemic Stroke Thus, the aim of our study was to examine association of miRNA gene polymorphisms (namely, miR-126 rs4636297, miR-149 rs2292832, miR-124 rs531564, miR-499 rs3746444, miR-143 rs12655723, and miR-122 rs17669) with recurrence of ischemic stroke. +transcription factor target 31811458 hsa-mir-494 Parkinson Disease PPX inhibited MPP(+)-induced neurotoxicity in SK-N-SH and CHP 212 cells by decreasing miR3p and increasing BDNF, indicating the potential therapeutic effect of PPX on Parkinson's disease. +other 31811458 hsa-mir-494 Neuroblastoma 3p/brain derived neurotrophic factor (BDNF) axis. +genetics_knock down_promote 31811458 hsa-mir-494 Neurotoxicity Syndromes Knockdown of miR +other 31811234 hsa-mir-150 Breast Neoplasms 5p, were differentially-expressed within both cohorts (BCNR-BCR, BCR-BM) and receiver-operating characteristic curve analysis (p=0.00137) and Kaplan-Meier survival method (p=0.0029, brain metastasis-free survival; p=0.0007, overall survival) demonstrated their potential use as prognostic markers. +other 31811234 hsa-mir-199a Breast Neoplasms 5p, were differentially-expressed within both cohorts (BCNR-BCR, BCR-BM) and receiver-operating characteristic curve analysis (p=0.00137) and Kaplan-Meier survival method (p=0.0029, brain metastasis-free survival; p=0.0007, overall survival) demonstrated their potential use as prognostic markers. +lncRNA target 31811115 hsa-mir-203 Urinary Bladder Neoplasms Taken together, our studies, for the first time revealed that: (1) BIR2 and BIR3 domains of XIAP play their role in cancer cell invasion without affecting cell migration by specific activation of MMP2 in human BC cells; (2) by BIR2 interacting with E2F1 and BIR3 interacting with Sp1, XIAP initiates E2F1/Sp1 positive feedback loop-dependent transcription of miR-203, which in turn inhibits Src protein translation, further leading to MMP2-cleaved activation; (3) XIAP interaction with E2F1 and Sp1 is observed in the nucleus. +transcription factor target 31810911 hsa-mir-3687 Esophageal Squamous Cell Carcinoma CONCLUSION: miR-3687 may be a candidate miRNA conferring BSCCE aggressiveness, and PGRMC2 is one of its target genes. +transcription factor target 31810510 hsa-mir-155 Intestinal Diseases Combining the ROC curve data, the results further prove that miR-155 and claudin1 might be the new clinical diagnostic markers and treatment targets for the intestinal mucosal barrier dysfunction after TBI. +transcription factor target 31810510 hsa-mir-155 Brain Injuries Combining the ROC curve data, the results further prove that miR-155 and claudin1 might be the new clinical diagnostic markers and treatment targets for the intestinal mucosal barrier dysfunction after TBI. +genetics_GWAS 31810492 hsa-mir-484 Uterine Cervical Neoplasms CONCLUSION: Our finding characterizes miR-484 as a key suppressive regulator in CC metastasis and reveals a DNMT1-mediated epigenetic mechanism for miR-484 silencing, expanding our understanding of the molecular mechanism underlying CC progression and metastasis. +genetics_knock down_promote 31810385 hsa-mir-1 Squamous Cell Carcinoma of Head and Neck In conclusion, LINC01518 knockdown inhibited tumorigenicity in ESCC cells by suppression of PIK3CA/Akt pathway through upregulating miR +other 31810373 hsa-mir-217 Pancreatic Carcinoma In this research, low miR-217 and high circ-ADAM9 expression were found in PC tissues and cell lines, which was closely associated with advanced clinical stage and lymph node metastasis. Briefly, the ceRNA regulatory network of circ-ADAM9/miR-217/PRSS3 plays a pivotal role in PC progression by the regulation of ERK/VEGF signalling pathway. +circulation_biomarker_prognosis_up 31810245 hsa-mir-214 Carcinoma, Ovarian Epithelial 3p in serum exosomes can be a potential biomarker for the diagnosis and prognosis of ovarian tumor, and its inhibition can be a supportive treatment for EOC. +genetics_knock down_promote 31810117 hsa-mir-148a Nasopharyngeal Carcinoma Both XIST knockdown and miR-148a-3p overexpression promoted apoptosis, suppressed cell proliferation, migration, invasion, and EMT of NPC cells in vitro. +other 31809872 hsa-mir-144 Myelodysplastic Syndromes CONCLUSION: Taken together, these studies demonstrate the stimulative role of miR-144 in MDS progression by regulating AKAP12-dependent ERK1/2 signaling pathway. +other 31809862 hsa-mir-532 Alzheimer Disease 18 miRNAs were significantly correlated with neurodegeneration (Benjamini-Hochberg adjusted P<0.05) with highest significance for miR5p (Benjamini-Hochberg adjusted P=4.8x10(-30)). +circRNA target 31809842 hsa-mir-337 Uterine Cervical Neoplasms For mechanism investigation, hsa_circ_0001038 could sponge miR3p to release its suppression on cyclin-M3 (CNNM3) and metastasis-associated in colon cancer 1 (MACC1), thereby promoting CC cell growth and invasive potential, respectively. +circRNA target 31809842 hsa-mir-337 Colonic Neoplasms For mechanism investigation, hsa_circ_0001038 could sponge miR3p to release its suppression on cyclin-M3 (CNNM3) and metastasis-associated in colon cancer 1 (MACC1), thereby promoting CC cell growth and invasive potential, respectively. +genetics_knock down_promote 31809639 hsa-mir-455 Osteoarthritis 3p overexpression on IL-1beta-induced OA-like phenomenon. +circulation_biomarker_diagnosis_ns 31809304 hsa-mir-25 Myocardial Reperfusion Injury Furthermore, administration of both miR-25 agomir and lentivirus-mediated short hairpin RNA (shRNA) interference targeting HMGB1 sh-HMGB1 resulted in reduced serum myocardial enzyme activities, cytokine secretion, and myocardial apoptosis during myocardial IRI. CONCLUSION: MiR-25 mitigated myocardial IRI-induced damage by targeting HMGB1. +circulation_biomarker_diagnosis_ns 31809227 hsa-mir-199a Carcinoma, Squamous Cell, Cutaneous Our results revealed that the miR-199a-5p/Sirt1/CD44ICD signaling pathway regulates cSCCSCs progression by affecting its migration ability and tumorigenicity, therefore can be utilized to develop a curative approach for cSCC.Abbreviations: CSCs: cancer stem cells; cSCC cutaneous squamous cell carcinoma; cSCCSCs: cSCC stem cells; CD44ICD: CD44 intracellular domain; HA: hyaluronic acid; HNSCC: hand and neck squamous cell carcinoma; ESCC: esophageal squamous cell carcinoma;MMPs: matrix metalloproteinases; SFM: sphere formation medium; EGF: epidermal growth factor; bFGF: basic fibroblast growth factor; BSA: bovine serum albumin; CCK-8: cell counting kit-8. +other 31809209 hsa-mir-148a Periodontitis We also found, compared to healthy periodontal tissues, miR-148a level increased, while NRP1 level decreased in periodontitis tissues. To summarize, the decline of osteogenic potential of PDLSCs under inflammatory condition of periodontitis is related to miR-148a/NRP1 functional axis. +other 31808923 hsa-mir-1915 high grade glioma 5p). +other 31808923 hsa-mir-4763 high grade glioma 5p). +transcription factor target 31808606 hsa-mir-143 Hepatitis, Autoimmune miRNA-143 regulates inflammation and fibrosis through its regulation of TAK1 phosphorylation, which warrants TAK1 as a target for the development of new therapeutic strategy of autoimmune hepatitis. +transcription factor target 31808606 hsa-mir-143 Liver Cirrhosis miRNA-143 regulates inflammation and fibrosis through its regulation of TAK1 phosphorylation, which warrants TAK1 as a target for the development of new therapeutic strategy of autoimmune hepatitis. +lncRNA target 31807249 hsa-mir-155 Myocardial Reperfusion Injury OBJECTIVES: The aim of this study was to identify the role of miR-155 in the myocardial ischemia/reperfusion (I/R) injury through targeting hypoxia-inducible factor 1-alpha (HIF-1alpha). +genetics_overexpression_promote 31807188 hsa-mir-101 Stomach Neoplasms The results obtained in the present study revealed that MANCR expression was associated with the survival of patients with GC, and MANCR overexpression in vitro may promote GC by downregulating miR-101 and increasing the proliferation of GC cells. +genetics_overexpression_promote 31807185 hsa-mir-133a Carcinoma, Non-Small-Cell Lung Moreover, the overexpression of miR-133a inhibited proliferation of NSCLC cells. +lncRNA target 31807180 hsa-mir-139 Carcinoma, Hepatocellular 5p expression is capable of accelerating tumor progression and is associated with a poor clinical outcome by modulating the expression of downstream target genes involved in tumor-associated signaling pathways. +transcription factor target 31807170 hsa-mir-31 Colorectal Neoplasms 3p restoration evidently suppressed CRC cell EMT. +transcription factor target 31807151 hsa-mir-448 Neuralgia Collectively, the results of the present study revealed that miR-448 promoted neuropathic pain in CCI rats by regulating neuroinflammation via SIRT1. +circulation_biomarker_diagnosis_up 31807149 hsa-mir-195 Venous Thrombosis 5p, and that Bcl-2 was downregulated in the blood of patients with DVT. +genetics_overexpression_suppress 31807116 hsa-mir-346 Glioma Overexpression of miR-346 arrested the cell cycle of glioma cells and inhibited their proliferation in vitro and in vivo. +genetics_overexpression_promote 31807077 hsa-mir-1305 Carcinoma, Non-Small-Cell Lung Overexpression of miR-1305 inhibited the proliferation and migration and promoted the apoptosis of NSCLC cells. +other 31807065 hsa-mir-124 Stomach Neoplasms Further studies indicate that down-regulated miR3p expression contributes to upregulated MST4 expression in GC. +genetics_overexpression_suppress 31807027 hsa-mir-152 Glioblastoma RESULTS: In the current study, we discovered that overexpression of miR +lncRNA target 31807021 hsa-mir-133b Carcinoma, Non-Small-Cell Lung A total of 362 genes were considered as the potential targets of miR-133b in NSCLC. +other 31807017 hsa-mir-29c Carcinoma, Hepatocellular In addition, miR-29c was downregulated in LIHC and negatively linked to linc00511 level. A negative interaction between linc00511 and miR-29c could be a regulatory feedback influencing the progression of LIHC. +circulation_biomarker_diagnosis_ns 31807009 hsa-mir-640 Carcinoma, Hepatocellular A dual-luciferase reporter assay was used to confirm the interaction between hsa-circ-0046600 and miR-640, and a meta-analysis confirmed the expression of miR-640 in HCC. hsa-circ-0046600 is present mainly in the cytoplasm and promotes the expression of proteins such as HIF-1alpha by competitively binding to miR-640 in HCC, thereby affecting the malignant biological behaviour of liver cancer cells. +epigenetics 31807007 hsa-mir-125a Adenocarcinoma of Lung KIF18B was predictively targeted by miR-125a-5p, which was downregulated in LUAD tissues, inversely correlated with KIF18B mRNA expression and significantly associated with poor OS. DNA amplification, hypomethylation as well as miR-125a-5p downregulation may be involved in the mechanism of KIF18B dysregulation in LUAD. +lncRNA target 31807005 hsa-mir-181b Colorectal Neoplasms Bioinformatics and luciferase reporter assays showed that miR-181b-5p was a direct target of CCAT1, and the expression of miR-181b-5p was negatively correlated with the expression of CCAT1 in CRC tissues. +genetics_overexpression_promote 31807004 hsa-mir-144 Carcinoma, Hepatocellular Enforced overexpression of miR-144 markedly inhibited the CLK3 expression while overexpression of CLK3 partially reversed the inhibitory function of miR-144 on HCC cell growth and metastasis. +lncRNA target 31807001 hsa-mir-129 Carcinoma, Non-Small-Cell Lung Moreover, miR-129 restoration could inhibit EMT and Wnt/beta-catenin in NSCLC cell lines. +other 31806989 hsa-mir-128 Retinoblastoma 3p and LASP1 in retinoblastoma tissues and cell lines were detected using qRT-PCR. +other 31806989 hsa-mir-182 Retinoblastoma 3p and LASP1 in retinoblastoma tissues and cell lines were detected using qRT-PCR. +lncRNA target 31806673 hsa-mir-3150b Carcinoma, Hepatocellular CONCLUSION: MiR-3150b suppressed HCC cell proliferation, invasion and migration by targeting GOLPH3. +genetics_overexpression_promote 31806569 hsa-mir-215 Inflammation Final rescue assays confirmed that the overexpression of LRRFIP1 or ILF3 rescued the repressive effect of miR +transcription factor target 31806569 hsa-mir-215 Sepsis Totally, miR5p exerted protective function in the inflammation injury in septic H9c2 via targeting ILF3 and LRRFIP1, suggesting an additional treatment method for sepsis-activated myocardial inflammation. +transcription factor target 31806569 hsa-mir-215 Myocarditis 5p exerted protective function in the inflammation injury in septic H9c2 via targeting ILF3 and LRRFIP1, suggesting an additional treatment method for sepsis-activated myocardial inflammation. +other 31806407 hsa-mir-21 Hepatitis C CONCLUSION Along the spectrum of HCV-related chronic liver disease, miR5p could be a potential marker for advanced liver damage while miR-21 could be a helpful diagnostic marker for HCC. +other 31806407 hsa-mir-885 Liver Injury CONCLUSION Along the spectrum of HCV-related chronic liver disease, miR5p could be a potential marker for advanced liver damage while miR-21 could be a helpful diagnostic marker for HCC. +other 31806407 hsa-mir-21 Liver Injury CONCLUSION Along the spectrum of HCV-related chronic liver disease, miR5p could be a potential marker for advanced liver damage while miR-21 could be a helpful diagnostic marker for HCC. +other 31806407 hsa-mir-885 Hepatitis C CONCLUSION Along the spectrum of HCV-related chronic liver disease, miR5p could be a potential marker for advanced liver damage while miR-21 could be a helpful diagnostic marker for HCC. +other 31805863 hsa-mir-185 Mastitis The expression of two miRNAs (bta-miR-378 and bta-miR-185) with high read counts and log(2) fold changes (> 3.5) was significantly higher in mastitic milk infected with S. +other 31805863 hsa-mir-185 Digitorenocerebral Syndrome The expression of two miRNAs (bta-miR-378 and bta-miR-185) with high read counts and log(2) fold changes (> 3.5) was significantly higher in mastitic milk infected with S. +other 31805718 hsa-mir-3116 Urinary Bladder Neoplasms 3p- PPM1K (protein phosphatase 1K). +other 31805718 hsa-mir-22 Urinary Bladder Neoplasms 3p- PPM1K (protein phosphatase 1K). +other 31805718 hsa-mir-185 Urinary Bladder Neoplasms 3p- PPM1K (protein phosphatase 1K). +other 31805718 hsa-mir-1 Urinary Bladder Neoplasms 3p- PPM1K (protein phosphatase 1K). +circulation_biomarker_diagnosis_ns 31805682 hsa-mir-155 Inflammation The programming induced by maternal obesity was accompanied by increased expression of miR-155 in peripheral-blood mononuclear cells and reduced miR-133b in trachea and lung tissue in adult life. +circulation_biomarker_diagnosis_ns 31805682 hsa-mir-155 Obesity, Maternal The programming induced by maternal obesity was accompanied by increased expression of miR-155 in peripheral-blood mononuclear cells and reduced miR-133b in trachea and lung tissue in adult life. +circulation_biomarker_diagnosis_ns 31805682 hsa-mir-133b Inflammation The programming induced by maternal obesity was accompanied by increased expression of miR-155 in peripheral-blood mononuclear cells and reduced miR-133b in trachea and lung tissue in adult life. +circulation_biomarker_diagnosis_ns 31805682 hsa-mir-133b Obesity, Maternal The programming induced by maternal obesity was accompanied by increased expression of miR-155 in peripheral-blood mononuclear cells and reduced miR-133b in trachea and lung tissue in adult life. +epigenetics 31805646 hsa-mir-510 Essential Hypertension The hypermethylation of ACE II, SCNN1B, CKG, IFN-gamma gene, and miR-510 promoter were associated with hypertension, the common effect size (CES) = 6.0%, 95% CI, -0.002-11.26. +transcription factor target 31805371 hsa-mir-186 Spinal Cord Ischemia These data provide evidence that upregulation of miR5p improves neurological outcomes induced by spinal cord I/R injury and may inhibit neuroinflammation through Wnt5a-, TLR3-, or CXCL13-mediated signal pathway in spinal cord I/R injury. +genetics_overexpression_promote 31805277 hsa-mir-501 Carcinoma, Non-Small-Cell Lung Overexpression of RAP1A strongly attenuated the inhibitory effects of miR +transcription factor target 31805186 hsa-mir-8080 Prostatic Neoplasms, Castration-Resistant These results indicate luteolin inhibits CRPC by AR-V7 suppression through miR-8080, highlighting luteolin and miR-8080 as promising therapeutic agents for this disease. +lncRNA target 31805126 hsa-mir-513a Glioma These findings demonstrate a distinct role of IGF-1 signaling through miR-513a-5p-inhibited NEDD4L networks in influencing GBM's drug sensitivity to TMZ. +other 31804973 hsa-mir-203 Neurodegenerative Diseases In addition, we showed that miR-203 expression was downregulated in degenerative NP samples, and miR-203 expression reduced gradually along with the grade of exacerbation of disc degeneration. +other 31804973 hsa-mir-203 Intervertebral Disc Degeneration In addition, we showed that miR-203 expression was downregulated in degenerative NP samples, and miR-203 expression reduced gradually along with the grade of exacerbation of disc degeneration. +other 31803920 hsa-mir-135 Digestive System Neoplasms CONCLUSION MiR-135 can be used as a novel biomarker for patients with digestive system cancers. +other 31803739 hsa-mir-506 Colorectal Neoplasms METHODS: In the present study, the levels of miR-506, UHRF1 and KISS1 expression in CRC tissues and in human CRC cell lines were studied using quantitative real-time PCR (qRT-PCR) and Western blotting. +lncRNA target 31803607 hsa-mir-184 Retinoblastoma Thus, targeting the miR-184/SLC7A5 pathway will provide new opportunities for drug development to reverse chemotherapeutic resistance in RB. +other 31803323 hsa-mir-1 Systemic Inflammatory Response Syndrome METHODS: This study evaluated if intraoperative cytokine reduction by HA modulates SIRS and affects myocardial injury as measured by miRNA-126, 223 and miRNA-1, 133a, respectively. +genetics_overexpression_promote 31803183 hsa-mir-636 Cystic Fibrosis Collectively, our findings reveal a novel actor for the regulation of inflammation in CF, miR-636, which is able to reduce constitutive NF-kappaB pathway activation when it is overexpressed. +genetics_overexpression_promote 31802912 hsa-mir-522 Osteosarcoma 3p overexpression led to upregulated GLUT1 expression and increase glucose uptake. +genetics_overexpression_suppress 31802909 hsa-mir-503 Carcinoma, Non-Small-Cell Lung miR-503 overexpression significantly inhibited NSCLC cell proliferation, migration and invasion. +lncRNA target 31802902 hsa-mir-186 Esophageal Neoplasms 5p may inhibit cell proliferation of ECa by regulating HOXA9. +genetics_overexpression_promote 31802897 hsa-mir-214 Stomach Neoplasms NOARD could also inhibit the apoptosis of GC cells by down-regulating caspase-3; however, miR-214 overexpression attenuated this effect. +other 31802892 hsa-mir-107 Esophageal Squamous Cell Carcinoma CONCLUSION: In this study, we found that LINC00152 modulated Rab10 to promote cell proliferation, migration and invasion in ESCC by sponging miR-107. +lncRNA target 31802890 hsa-mir-4766 Stomach Neoplasms 5p suppressed the proliferation and metastasis of gastric cancer cells through targeting NKAP. +genetics_knock down_promote 31802889 hsa-mir-204 Urinary Bladder Neoplasms The impacts of miR-204 on BC cell growth and metastasis in vitro were evaluated by both loss-of-function and gain-of-function assays (CCK-8, crystal violet staining, wound healing and transwell assays). +lncRNA target 31802888 hsa-mir-191 Carcinoma, Transitional Cell CONCLUSION: circ-Foxo3 was downregulated in bladder cancer in vivo and in vitro, and promoted bladder cancer apoptosis via direct interaction with miR-191. +lncRNA target 31802830 hsa-mir-375 Colorectal Neoplasms CONCLUSION: Our findings suggest that suppressing MIR375 expression in CRC regulates cell proliferation and angiogenesis by increasing MTDH expression. +lncRNA target 31802650 hsa-mir-34a Colorectal Neoplasms RESULTS: We found that NEAT1 expression was increased in CRC tissues and cells, which showed a negative correlation with miR-34a expression. CONCLUSION: These findings indicate that LncRNA NEAT1 could target miR-34a and promote autophagy to facilitate 5-FU chemoresistance in CRC. +other 31802245 hsa-mir-499 Myocardial Infarction, Acute This study describes a fluorometric assay for multiplexed detection of the AMI biomarkers microRNA-499, microRNA-133a and microRNA-1. It demonstrates that the expressions of microRNA-499, microRNA-133a and microRNA-1 are significantly higher in AMI patients. +other 31802245 hsa-mir-133a Myocardial Infarction, Acute This study describes a fluorometric assay for multiplexed detection of the AMI biomarkers microRNA-499, microRNA-133a and microRNA-1. It demonstrates that the expressions of microRNA-499, microRNA-133a and microRNA-1 are significantly higher in AMI patients. +other 31802245 hsa-mir-1 Myocardial Infarction, Acute This study describes a fluorometric assay for multiplexed detection of the AMI biomarkers microRNA-499, microRNA-133a and microRNA-1. It demonstrates that the expressions of microRNA-499, microRNA-133a and microRNA-1 are significantly higher in AMI patients. +genetics_overexpression_promote 31801953 hsa-mir-137 Breast Neoplasms Consistently, decreased DUSP4 efficiently enhanced the sensitivity of BC cells to DOX while overexpressed DUSP4 significantly diminished the beneficial effect of miR-137 on BC cells chemoresistance. +genetics_overexpression_suppress 31801947 hsa-mir-1205 Squamous Cell Carcinoma of Head and Neck Overexpression of E2F1 reverses the inhibitory impacts of miR-1205 on LSCC cells in part. +lncRNA target 31801723 hsa-mir-146a Pneumonia OBJECTIVE: To investigate the effect of ulinastatin on the inflammatory mediators and their signaling pathways miR-146a/TLR4/NF-kappaB in rats with hemorrhagic shock. CONCLUSIONS: Ulinastatin combined with acetated Ringer's solution resuscitation alleviates lung inflammations in rats with hemorrhagic shock possibly by enhancing miR-146a expression to regulate TLR4/NF-kappaB signaling pathway through a negative feedback mechanism and thus modulate the balance of pro-inflammatory and anti-inflammatory factors. +lncRNA target 31801723 hsa-mir-146a Shock, Hemorrhagic OBJECTIVE: To investigate the effect of ulinastatin on the inflammatory mediators and their signaling pathways miR-146a/TLR4/NF-kappaB in rats with hemorrhagic shock. CONCLUSIONS: Ulinastatin combined with acetated Ringer's solution resuscitation alleviates lung inflammations in rats with hemorrhagic shock possibly by enhancing miR-146a expression to regulate TLR4/NF-kappaB signaling pathway through a negative feedback mechanism and thus modulate the balance of pro-inflammatory and anti-inflammatory factors. +other 31801721 hsa-mir-218 Placenta Accreta SLIT2 may play a role in the occurrence of PAS. +circulation_biomarker_prognosis_ns 31801711 hsa-mir-126 Adenocarcinoma of Lung 5p is lowered in lung adenocarcinoma tissue, and patients with lung adenocarcinoma have lower serum level of miR +lncRNA target 31801705 hsa-mir-205 Nasopharyngeal Carcinoma 5p-inhibitor, treated with 80 mumol/L 3-bromopyruvate alone, or exposed to both of the treatments. +other 31801690 hsa-mir-200c Triple Negative Breast Neoplasms PURPOSE: To investigate the effect of miR-200c/PAI-2 on macrophage polarization into M2-type TAMs in TNBC. CONCLUSIONS: miR-200c promotes the malignant progressions of TNBC by PAI-2 upregulation and M2 phenotype macrophages polarization. +genetics_GWAS 31801665 hsa-mir-100 Leukemia, Myeloid, Acute The expressions of miR-100 and ataxia telangiectasia mutated (ATM) in pediatric AML patients and cell lines were monitored using qRT-PCR and western blot assays. miR-100 participates in cell viability and apoptosis by targeting ATM in pediatric AML. +genetics_knock down_suppress 31801557 hsa-mir-1298 Carcinoma, Non-Small-Cell Lung CONCLUSION: All the data indicated that the downregulation of miR-1298 predicts poor prognosis of NSCLC, and the overexpression of miR-1298 in NSCLC cells leads to inhibited tumorigenesis. +genetics_knock down_promote 31801413 hsa-mir-181c Reperfusion Injury Loss of miR-181c can protect the heart from I/R injury by modulating [Ca(2+)](m) through the upregulation of MICU1. +transcription factor target 31801411 hsa-mir-129 Subarachnoid Hemorrhage The results indicated that Exo from BMSCs could alleviate EBI after SAH through miRNA129-5p's anti-inflammation and antiapoptosis effects through quenching the activity of HMGB1-TLR4 pathway. +transcription factor target 31801411 hsa-mir-129 Brain Injuries The results indicated that Exo from BMSCs could alleviate EBI after SAH through miRNA129-5p's anti-inflammation and antiapoptosis effects through quenching the activity of HMGB1-TLR4 pathway. +lncRNA target 31801250 hsa-mir-221 Liver Neoplasms Therefore, OB effectively exerts anticancer effects by positively regulating the PTEN gene and then inactivating the PI3K/Akt signaling pathway through down-regulating the expression of the microRNA-221, thereby inducing apoptosis of liver cancer cells. +other 31801218 hsa-mir-20 Mental Disorders These miRNAs and mRNAs were previously implicated in psychiatric disorders (miR-320a and SP4), key processes of the central nervous system (CAPNS1, RGS16, SP4) or pathways involved in mental illnesses (miR3p). +other 31801218 hsa-mir-155 Mental Disorders These miRNAs and mRNAs were previously implicated in psychiatric disorders (miR-320a and SP4), key processes of the central nervous system (CAPNS1, RGS16, SP4) or pathways involved in mental illnesses (miR3p). +other 31801218 hsa-mir-20a Mental Disorders These miRNAs and mRNAs were previously implicated in psychiatric disorders (miR-320a and SP4), key processes of the central nervous system (CAPNS1, RGS16, SP4) or pathways involved in mental illnesses (miR3p). +lncRNA target 31801112 hsa-mir-483 Osteosarcoma Thus, NR2F1-AS1 plays an oncogenic role in OS through sponging miR3p and thereby upregulating FOXA1, suggesting an additional target for osteosarcoma therapeutics. +other 31801064 hsa-mir-16 Herpesviridae Infections Altogether, our data show that KSHV encodes a functional mimic of miR-15/16 family miRNAs. +exosome 31800531 hsa-mir-451 Burns HUCMSC-Exo-derived miR-451 improves ALI via the TLR4/NF-kappaB pathway. CONCLUSION: We demonstrated that exosomes derived from hUCMSCs mediate miR-451 to attenuate burn-induced ALI. +exosome 31800531 hsa-mir-451 Acute Lung Injury HUCMSC-Exo-derived miR-451 improves ALI via the TLR4/NF-kappaB pathway. CONCLUSION: We demonstrated that exosomes derived from hUCMSCs mediate miR-451 to attenuate burn-induced ALI. +circulation_biomarker_diagnosis_down 31800303 hsa-mir-145 Prostatic Neoplasms Detection of circRNAs in PCa cells showed that circ_KATNAL1 is down-regulated, mainly located in the cytoplasm, and contains multiple binding sites of miR +genetics_GWAS 31800164 hsa-mir-21 Triple Negative Breast Neoplasms High in vivo anticancer efficiency against the MDA-MB-231 triple-negative breast cancer (TNBC) model is obtained due to the combination of genetic regulation of miR-21i and the photokilling effect of ICG. +other 31800144 hsa-mir-153 Parkinson Disease OBJECTIVE: To ascertain whether salivary miR-153 and miR-223 are similarly downmodulated in, and may serve as diagnostic biomarkers of, idiopathic PD. CONCLUSION: Salivary miR-153 and miR-223 levels may serve as useful, noninvasive, and relatively inexpensive diagnostic biomarkers of idiopathic PD. +other 31800144 hsa-mir-223 Parkinson Disease OBJECTIVE: To ascertain whether salivary miR-153 and miR-223 are similarly downmodulated in, and may serve as diagnostic biomarkers of, idiopathic PD. CONCLUSION: Salivary miR-153 and miR-223 levels may serve as useful, noninvasive, and relatively inexpensive diagnostic biomarkers of idiopathic PD. +transcription factor target 31799727 hsa-mir-129-1 Colonic Neoplasms 1-3p in human colon cancer cells caused morphological changes and suppressed tumor growth, cell adhesion, and invasion. +genetics_overexpression_suppress 31799682 hsa-mir-124 Myocardial Reperfusion Injury Rescue experiments demonstrated that circHIPK3 overexpression reversed the protective effects of miRNA +transcription factor target 31799678 hsa-mir-205 Non-alcoholic Fatty Liver Disease OBJECTIVE: The aim of this study was to explore the role of miR-205 in non-alcoholic fatty liver disease (NAFLD) and explore the underlying mechanism. CONCLUSIONS: Results revealed that miR-205 facilitated lipid accumulation by inhibiting NEU1 in NAFLD, suggesting that miR-205 might be a potential target for the therapeutic strategy for NAFLD. +other 31799677 hsa-mir-153 Fibrosis, Renal 3p/Bcl-2 in influencing RIF. +exosome 31799671 hsa-mir-10a Glioma CONCLUSIONS: Therefore, our data suggested that the exosomes from hUC-MSCs possess a higher anti-tumor capacity, at least partially, via regulating miR-10a-5p/PTEN signaling, which thereby may represent a possible target for early diagnosis and treatment of glioma clinically. +genetics_knock down_promote 31799669 hsa-mir-491 Breast Neoplasms The knockdown of TPX2 markedly reversed miR +genetics_overexpression_suppress 31799668 hsa-mir-1236 Breast Neoplasms Overexpression of ZEB1 in BCa cells can partially reverse the effect of overexpressed miR +genetics_overexpression_promote 31799665 hsa-mir-507 Carcinoma, Non-Small-Cell Lung Overexpression of miR-507 repressed NSCLC cell invasion and proliferation. +genetics_overexpression_promote 31799663 hsa-mir-621 Carcinoma, Non-Small-Cell Lung In addition, the overexpression of SYF2 remarkably enhanced gefitinib-resistance, while reversed the inhibitory effects of miRNA-621 on the proliferative ability and cell cycle of NSCLC cells. +genetics_overexpression_promote 31799659 hsa-mir-187 Stomach Neoplasms CONCLUSIONS: The overexpression of miR-187 alleviates DDP-resistance in gastric cancer cells by inhibiting the TGF-beta/Smad signaling pathway. +lncRNA target 31799657 hsa-mir-23a Stomach Neoplasms CONCLUSIONS: TOB1-AS1/miR-23a/NEU1 axis regulated proliferation, apoptosis, migration, and invasion of GC cells via Wnt/b-catenin pathway, providing the evidence for serving TOB1-AS1 as an underlying therapeutic target in human GC treatment. +lncRNA target 31799656 hsa-mir-34a Stomach Neoplasms Circ-DB, microRNA-34a, and MET expressions were detected by real time-quantitative PCR (RT-qPCR) in GCa tissues and adjacent tissues. CONCLUSIONS: Circ-DB may regulate MET level through microRNA-34a and affect the proliferative ability and migration of GCa cells. +lncRNA target 31799655 hsa-mir-944 Colorectal Neoplasms Moreover, miR-944 inhibitor abrogated silenced SNHG14-mediated inhibition on proliferation, migration and invasion, as well as promotion on apoptosis in CRC cells. +lncRNA target 31799653 hsa-mir-200b Carcinoma, Hepatocellular CONCLUSIONS: Above results suggest that XIST could enhance the cell growth ability of HCC by targeting miR-200b-3p, which suggest that XIST may be a potential therapeutic target in HCC. +other 31799652 hsa-mir-760 Carcinoma, Hepatocellular Meanwhile, microRNA-760 was remarkably lowly expressed in LCa tissues and cells. Subsequent experiments indicated that LINC01296 was regulated by miR760 in LCa tissues, and high expression of linc0129 could limit microRNA-760 expression. +lncRNA target 31799651 hsa-mir-193a Carcinoma, Hepatocellular Further experiments showed that miR-193a-3p was a direct target of ZFAS1 in HCC. CONCLUSIONS: ZFAS1 could enhance the proliferation of HCC cells by suppressing miR-193a-3p, which might be a potential therapeutic target in HCC. +lncRNA target 31799650 hsa-mir-335 Gallbladder Neoplasms MiR-335 may be a potential therapeutic target for gallbladder carcinoma. +lncRNA target 31799646 hsa-mir-98 Osteosarcoma 5p regulates cell cycle progression by down-regulating CDC25A, thus inhibiting the progression of osteosarcoma. +lncRNA target 31799645 hsa-mir-140 Osteosarcoma CONCLUSIONS: TUG1 modulated cell proliferation, migration, and invasion via miR5p/PFN2 axis in OS progression, which might trigger the development of therapeutic strategies for the treatment of OS. +genetics_knock down_promote 31799644 hsa-mir-665 Osteosarcoma Inhibited proliferative and migratory abilities of OS cells with SND1-IT1 knockdown were partially elevated by transfection of miRNA-665 inhibitor, and further downregulated by POU2F1 knockdown. +lncRNA target 31799643 hsa-mir-15b Femur Head Necrosis OBJECTIVE: The aim of this study was to explore the role of micro ribonucleic acid (miR)-15b in steroid-induced osteonecrosis of the femoral head (SONFH) and its potential mechanism. CONCLUSIONS: MiR-15b relieves SONFH by targeting Smad7 and repressing osteogenic differentiation of BMSCs. +lncRNA target 31799641 hsa-mir-223 Spinal Cord Injuries 5p inhibitor significantly declined the levels of apoptosis key enzyme-caspase-3 and glia reaction marker-glial fibrillary acidic protein (GFAP) at 7 and 28 days after SCI, respectively. +transcription factor target 31799640 hsa-mir-379 Spinal Cord Injuries 5p retarded the neurofilament regeneration block effect by inhibiting endothelin 1 and the expression of the astrocytes after SCI. +lncRNA target 31799639 hsa-mir-122 Osteoarthritis Moreover, ANRIL could regulate the proliferation and apoptosis of OAS via miR5p/DUSP4 axis. +lncRNA target 31799620 hsa-mir-3 Gallbladder Neoplasms The findings suggest that miR-33b up-regulation hinders GBC development through down-regulating CROCC, which was achieved by inhibition of EMT. +other 31798831 hsa-mir-146a Asthma CONCLUSION: Our results suggest that decreased level of miR-146a in HBECs from patients with asthma may contribute to the development of neutrophilic phenotype of asthma. +lncRNA target 31798828 hsa-mir-26a Osteosarcoma Cellular function assays were conducted and the findings revealed that circ_0051079/miR-26a-5p/TGF-beta1 regulated osteosarcoma proliferation and metastasis. CONCLUSION: The study demonstrated that circ_0051079 could act as an oncogene via regulating miR-26a-5p/TGF-beta1 and a potential biomarker for osteosarcoma diagnose. +other 31798637 hsa-mir-196a Radiation Injuries Selected miRNAs containing variants such as hsa-miR-146a-3p, hsa-miR-196a-3p, hsa-miR-548l, hsa-miR-449b-5p, hsa-miR-575, and hsa-miR499a-3p could regulate classical genes associated with Rasopathies and RAS-MAPK pathways, contributing to modify the expression pattern of miRNAs in patients. +other 31798637 hsa-mir-449b Radiation Injuries Selected miRNAs containing variants such as hsa-miR-146a-3p, hsa-miR-196a-3p, hsa-miR-548l, hsa-miR-449b-5p, hsa-miR-575, and hsa-miR499a-3p could regulate classical genes associated with Rasopathies and RAS-MAPK pathways, contributing to modify the expression pattern of miRNAs in patients. +other 31798637 hsa-mir-146a Radiation Injuries Selected miRNAs containing variants such as hsa-miR-146a-3p, hsa-miR-196a-3p, hsa-miR-548l, hsa-miR-449b-5p, hsa-miR-575, and hsa-miR499a-3p could regulate classical genes associated with Rasopathies and RAS-MAPK pathways, contributing to modify the expression pattern of miRNAs in patients. +other 31798637 hsa-mir-548l Radiation Injuries Selected miRNAs containing variants such as hsa-miR-146a-3p, hsa-miR-196a-3p, hsa-miR-548l, hsa-miR-449b-5p, hsa-miR-575, and hsa-miR499a-3p could regulate classical genes associated with Rasopathies and RAS-MAPK pathways, contributing to modify the expression pattern of miRNAs in patients. +other 31798637 hsa-mir-499a Radiation Injuries Selected miRNAs containing variants such as hsa-miR-146a-3p, hsa-miR-196a-3p, hsa-miR-548l, hsa-miR-449b-5p, hsa-miR-575, and hsa-miR499a-3p could regulate classical genes associated with Rasopathies and RAS-MAPK pathways, contributing to modify the expression pattern of miRNAs in patients. +other 31798637 hsa-mir-575 Radiation Injuries Selected miRNAs containing variants such as hsa-miR-146a-3p, hsa-miR-196a-3p, hsa-miR-548l, hsa-miR-449b-5p, hsa-miR-575, and hsa-miR499a-3p could regulate classical genes associated with Rasopathies and RAS-MAPK pathways, contributing to modify the expression pattern of miRNAs in patients. +lncRNA target 31798345 hsa-mir-206 Glioma CONCLUSIONS: Overall, the results demonstrated that UCA1/miR-206/CLOCK axis participated in the progressing of glioma and could act as a promising therapeutic target. +lncRNA target 31797734 hsa-mir-381 Squamous Cell Carcinoma of Head and Neck 3p targeted and suppressed NASP gene, reduced the viability, migration, invasion, EMT of HNSCC cells, demonstrating that miR +genetics_overexpression_promote 31797701 hsa-mir-922 Breast Neoplasms 5p were proved.Results: HOXC-AS3 is aberrantly overexpressed in breast cancers especially the HER2(+) type. +other 31796837 hsa-mir-660 Pulmonary Disease, Chronic Obstructive 5p in COPD fibroblasts, may represent one of the mechanisms underlying aberrant tissue repair and remodelling in COPD. +genetics_overexpression_promote 31796663 hsa-mir-105 Esophageal Squamous Cell Carcinoma In addition, overexpression of miR-105 promoted cell proliferation, migration, and invasion in esophageal cancer cells, while downregulation of miR-105 suppressed these cellular behaviors. +other 31796535 hsa-mir-196b Tuberculosis Logistic regression identified the combination of 4 sncRNA (let-7a-5p, miR5p, miR-196b-5p, and SNORD104) as a highly sensitive (100%) classifier to discriminate TB from all non-TB groups. +other 31796535 hsa-mir-589 Tuberculosis Logistic regression identified the combination of 4 sncRNA (let-7a-5p, miR5p, miR-196b-5p, and SNORD104) as a highly sensitive (100%) classifier to discriminate TB from all non-TB groups. +other 31796535 hsa-let-7a Tuberculosis Logistic regression identified the combination of 4 sncRNA (let-7a-5p, miR5p, miR-196b-5p, and SNORD104) as a highly sensitive (100%) classifier to discriminate TB from all non-TB groups. +genetics_overexpression_suppress 31796150 hsa-mir-6884 Stomach Neoplasms Overexpression of S100A16 in GC cells partially reversed the inhibitory effects of the miR +lncRNA target 31796120 hsa-mir-146a Epilepsy, Temporal Lobe Silencing of miRNA-146a alleviated the neuronal damage in the hippocampus of TLE rats by down-regulating Notch-1. +circulation_biomarker_diagnosis_ns 31796072 hsa-mir-23a Central Nervous System, Non-Infectious We profiled serum and CSF samples using quantitative real-time PCR (qPCR) searching for selected and previously profiled miRNAs in serum (let-7a, let-7c, miR-15b, miR-16, miR-21, miR-23a, miR-24, miR-26a, miR-146a, miR-155, miR-181c and miR +circulation_biomarker_diagnosis_ns 31796072 hsa-let-7c Central Nervous System, Non-Infectious We profiled serum and CSF samples using quantitative real-time PCR (qPCR) searching for selected and previously profiled miRNAs in serum (let-7a, let-7c, miR-15b, miR-16, miR-21, miR-23a, miR-24, miR-26a, miR-146a, miR-155, miR-181c and miR +circulation_biomarker_diagnosis_ns 31796072 hsa-mir-16 Central Nervous System, Non-Infectious We profiled serum and CSF samples using quantitative real-time PCR (qPCR) searching for selected and previously profiled miRNAs in serum (let-7a, let-7c, miR-15b, miR-16, miR-21, miR-23a, miR-24, miR-26a, miR-146a, miR-155, miR-181c and miR +circulation_biomarker_diagnosis_ns 31796072 hsa-mir-26a Central Nervous System, Non-Infectious We profiled serum and CSF samples using quantitative real-time PCR (qPCR) searching for selected and previously profiled miRNAs in serum (let-7a, let-7c, miR-15b, miR-16, miR-21, miR-23a, miR-24, miR-26a, miR-146a, miR-155, miR-181c and miR +circulation_biomarker_diagnosis_ns 31796072 hsa-mir-21 Central Nervous System, Non-Infectious We profiled serum and CSF samples using quantitative real-time PCR (qPCR) searching for selected and previously profiled miRNAs in serum (let-7a, let-7c, miR-15b, miR-16, miR-21, miR-23a, miR-24, miR-26a, miR-146a, miR-155, miR-181c and miR +circulation_biomarker_diagnosis_ns 31796072 hsa-mir-24 Central Nervous System, Non-Infectious We profiled serum and CSF samples using quantitative real-time PCR (qPCR) searching for selected and previously profiled miRNAs in serum (let-7a, let-7c, miR-15b, miR-16, miR-21, miR-23a, miR-24, miR-26a, miR-146a, miR-155, miR-181c and miR +circulation_biomarker_diagnosis_ns 31796072 hsa-mir-15b Central Nervous System, Non-Infectious We profiled serum and CSF samples using quantitative real-time PCR (qPCR) searching for selected and previously profiled miRNAs in serum (let-7a, let-7c, miR-15b, miR-16, miR-21, miR-23a, miR-24, miR-26a, miR-146a, miR-155, miR-181c and miR +circulation_biomarker_diagnosis_ns 31796072 hsa-mir-221 Central Nervous System, Non-Infectious We profiled serum and CSF samples using quantitative real-time PCR (qPCR) searching for selected and previously profiled miRNAs in serum (let-7a, let-7c, miR-15b, miR-16, miR-21, miR-23a, miR-24, miR-26a, miR-146a, miR-155, miR-181c and miR +circulation_biomarker_diagnosis_ns 31796072 hsa-mir-155 Central Nervous System, Non-Infectious We profiled serum and CSF samples using quantitative real-time PCR (qPCR) searching for selected and previously profiled miRNAs in serum (let-7a, let-7c, miR-15b, miR-16, miR-21, miR-23a, miR-24, miR-26a, miR-146a, miR-155, miR-181c and miR +circulation_biomarker_diagnosis_ns 31796072 hsa-let-7a Central Nervous System, Non-Infectious We profiled serum and CSF samples using quantitative real-time PCR (qPCR) searching for selected and previously profiled miRNAs in serum (let-7a, let-7c, miR-15b, miR-16, miR-21, miR-23a, miR-24, miR-26a, miR-146a, miR-155, miR-181c and miR +circulation_biomarker_diagnosis_ns 31796072 hsa-mir-181c Central Nervous System, Non-Infectious We profiled serum and CSF samples using quantitative real-time PCR (qPCR) searching for selected and previously profiled miRNAs in serum (let-7a, let-7c, miR-15b, miR-16, miR-21, miR-23a, miR-24, miR-26a, miR-146a, miR-155, miR-181c and miR +circulation_biomarker_diagnosis_ns 31796072 hsa-mir-146a Central Nervous System, Non-Infectious We profiled serum and CSF samples using quantitative real-time PCR (qPCR) searching for selected and previously profiled miRNAs in serum (let-7a, let-7c, miR-15b, miR-16, miR-21, miR-23a, miR-24, miR-26a, miR-146a, miR-155, miR-181c and miR +genetics_overexpression_promote 31795847 hsa-mir-200b Adenocarcinoma of Lung Lung adenocarcinoma cell phenotypes induced by microRNA-200b-3p overexpression could be partially remitted by the co-overexpression of microRNA-200b-3p and adenosine triphosphate-binding cassette transporter A-1. +transcription factor target 31795469 hsa-mir-153 Squamous Cell Carcinoma of Head and Neck Our findings detail how WISP-1 promotes EMT via the miR +other 31795200 hsa-mir-99a Squamous Cell Carcinoma of Head and Neck Here, we screened miR-99a-3p-controlled oncogenes involved in HNSCC pathogenesis. +other 31794845 hsa-mir-1885 Benign Paroxysmal Positional Vertigo Interestingly, upon Turnip mosaic virus (TuMV) infection, miR1885-dependent trans-acting silencing of BraCP24 was enhanced to speed up the floral transition, whereas miR1885-mediated R gene turnover was overcome by TuMV-induced BraTNL1 expression, reflecting precise regulation of the arms race between plants and pathogens. +other 31794845 hsa-mir-1885 Avulavirus Infections Interestingly, upon Turnip mosaic virus (TuMV) infection, miR1885-dependent trans-acting silencing of BraCP24 was enhanced to speed up the floral transition, whereas miR1885-mediated R gene turnover was overcome by TuMV-induced BraTNL1 expression, reflecting precise regulation of the arms race between plants and pathogens. +lncRNA target 31794744 hsa-mir-485 Reperfusion Injury, Cerebral Ischemia RESULTS: In both MCAO rats and OGD/R-treated neurocytes, MEG3 and AIM2 were significantly up-regulated, whereas miR-485 was down-regulated. CONCLUSION: MEG3/miR-485/AIM2 axis contributes to pyroptosis via activating caspase1 signaling during cerebral I/R, suggesting that this axis may be a potent therapeutic target in ischemic stroke. +lncRNA target 31794425 hsa-mir-363 Ovarian Neoplasms Moreover, 6 pseudogenes and 8 lncRNAs were identified to potentially inhibit hsa-miR +lncRNA target 31793993 hsa-mir-217 Stomach Neoplasms miR-217 induced the down-regulation of PTPN14 and inhibited the EMT in gastric cancer cells. +lncRNA target 31793989 hsa-mir-124 Stomach Neoplasms Taken together, our studies disclosed that circ-PVT1 facilitated PTX resistance by up-regulating ZEB1 mediated via miR +lncRNA target 31793741 hsa-mir-449a Carcinoma, Non-Small-Cell Lung METHODS: The expression of SNHG7, miR-449a and TGIF2 in NSCLC tumors and cells was examined by quantitative real time polymerase chain reaction (qRT-PCR). CONCLUSION: SNHG7 contributed to cell proliferation, migration, invasion and EMT in NSCLC by upregulating TGIF2 via sponging miR-449a, representing a novel targeted therapy method for NSCLC. +genetics_overexpression_promote 31793097 hsa-mir-142 Melanoma 3p inhibitor or Rheb overexpression. +genetics_overexpression_promote 31793097 hsa-mir-142 Microphthalmos 3p inhibitor or Rheb overexpression. +other 31793054 hsa-let-7f Leukemia The study aimed to investigate whether the let-7f mediate the Adriamycin (ADR) resistance of leukemia, and to explore the potential molecular mechanism. Taken together, the let-7f downregulation induced the ADR resistance of leukemia by upregulating ABCC5 and ABCC10 expression. +genetics_knock down_promote 31793036 hsa-mir-627 Carcinoma, Hepatocellular 5p knockdown enhanced the expression of BCL3 protein in HCC cells. +genetics_overexpression_promote 31792998 hsa-mir-367 Uterine Cervical Neoplasms 3p overexpression restricts the proliferation and invasion of cervical cancer cells through targeting SPAG5 to downregulate Wnt/beta-catenin signalling, suggesting a mechanism for the tumour suppressive function of miR +genetics_knock down_promote 31792806 hsa-mir-206 Reperfusion Injury The knockdown of Cx43 inversed the protective effects of miR-206 inhibitor on cardiac arrhythmias. +other 31792649 hsa-mir-140 Myocardial Reperfusion Injury In the present study, we aimed to explore whether miR140-3p was involved in the underlying molecular mechanisms of small nucleolar RNA host gene 1 (SNHG1) in myocardial ischemia/reperfusion (I/R) injury. +other 31792483 hsa-mir-1260 Periodontitis CONCLUSIONS: miRNAs expression profiles were obtained in periodontitis tissues, periodontitis-induced hsa-miR-1260 and hsa-miR-451 may play a key role in the pathophysiology of periodontitis. +other 31792483 hsa-mir-451 Periodontitis CONCLUSIONS: miRNAs expression profiles were obtained in periodontitis tissues, periodontitis-induced hsa-miR-1260 and hsa-miR-451 may play a key role in the pathophysiology of periodontitis. +other 31792476 hsa-mir-218 Tongue Neoplasms PURPOSE: To study the effects of miR-218 on cell proliferation, apoptosis and invasion of human tongue cancer cell line SCC-4 and SCC-9 cells. CONCLUSIONS: The expression level of miR-218 in tongue cancer cell lines may be correlated with cell proliferation, apoptosis and invasion. +lncRNA target 31792428 hsa-mir-668 Dysentery, Bacillary By characterizing a small subset of miRNAs chosen among the strongest inhibitors of Shigella infection, we discovered that miR-3668, miR5p and miR-6073 exert a selective effect on Shigella infection by impairing bacterial actin-based motility by downregulating N-WASP. +lncRNA target 31792428 hsa-mir-4732 Dysentery, Bacillary By characterizing a small subset of miRNAs chosen among the strongest inhibitors of Shigella infection, we discovered that miR-3668, miR5p and miR-6073 exert a selective effect on Shigella infection by impairing bacterial actin-based motility by downregulating N-WASP. +other 31792053 hsa-mir-122 Hepatitis C MicroRNA-122 (miR-122) is highly expressed in hepatocytes, where it plays an important role in regulating cholesterol and fatty acid metabolism, and it is also a host factor required for hepatitis C virus replication. +lncRNA target 31791845 hsa-mir-4701 Arthritis, Rheumatoid INTERPRETATION: Our results reveal PICSAR may exert an essential role in promoting synovial invasion and joint destruction by sponging miR +lncRNA target 31791587 hsa-mir-199a Thyroid Neoplasms The interaction within lncRNA, miRNA and target mRNA constructed the feedback loop of SP1/SNHG1/miR-199a-5p/SP1 in PTC. +other 31791014 hsa-mir-150 Tuberculosis 5p)/FOSL2 feedback loop played an essential role in regulating BTB permeability. +other 31791014 hsa-mir-138 Tuberculosis 5p)/FOSL2 feedback loop played an essential role in regulating BTB permeability. +other 31791013 hsa-mir-223 Brain Ischemia 5p by antimiRNA is a reasonable strategy to reduce the neurodetrimental effect induced by NCKX2 downregulation during brain ischemia. +genetics_GWAS 31790972 hsa-mir-140 Osteoarthritis Collectively, miR-140 can effectively attenuate the progression of early-stage OA by retarding chondrocyte senescence, contributing new evidence of the involvement of miR-mediated epigenetic regulation of chondrocyte senescence in OA pathogenesis. +lncRNA target 31790896 hsa-mir-181b Fibrosis Collectively, we demonstrate that LQ inhibits liver fibrosis, at least in part, via regulation of miR-181b and PTEN. +transcription factor target 31790686 hsa-mir-214 Pancreatitis 3p is indicated to exacerbate the tissue damages and inflammatory response caused by HP complicated with acute renal injury, which may provide a novel therapeutic perspective targeting miR +transcription factor target 31790686 hsa-mir-214 Inflammation 3p is indicated to exacerbate the tissue damages and inflammatory response caused by HP complicated with acute renal injury, which may provide a novel therapeutic perspective targeting miR +lncRNA target 31790145 hsa-mir-490 Leukemia, Myeloid, Acute 3p/MAPK1/c-Myc positive feedback loop in AML progression. +other 31789625 hsa-mir-7 Carcinoma, Non-Small-Cell Lung MicroRNA-7 is a significant microRNA in non-small cell lung cancer. Thus, we used qPCR to measure microRNA-7 expression in A549 non-small cell lung cancer cells treated with metformin. +other 31789465 hsa-mir-539 Carcinoma, Pancreatic Ductal Mechanistic studies uncovered that lncRNA LUCAT1 acted as a molecular sponge of miR-539 and that miR-539 mediated the effects of lncRNA LUCAT1 on PDAC cell proliferation, cell cycle progression, and motility. +lncRNA target 31789421 hsa-mir-145 Uterine Cervical Neoplasms Moreover, FTH1P3 siRNA partially attenuated the effects of the miR145 inhibitor on cell viability and mobility in cervical cancer cells. +genetics_overexpression_suppress 31789419 hsa-mir-337 Stomach Neoplasms Overexpression of miR3373p in gastric cancer cells resulted in the reduction of their invasive abilities. +lncRNA target 31789416 hsa-mir-194 Glioblastoma Thus, Unigene56159 may function as a competing endogenous RNA by sequestering miR1945p in GBM cells. These findings suggested that Unigene56159 may serve an oncogenic role in GBM and may promote disease progression through interacting with miR1945p. +lncRNA target 31789414 hsa-mir-26a Ovarian Neoplasms These results indicated that miR26a may act as a tumor suppressor in OC, and TCF12 targeting by miR26a may be a new therapeutic strategy for OC. +other 31789396 hsa-mir-7 Triple Negative Breast Neoplasms The present study investigated breast cancerrelated ncRNAs [microRNA (miR)7, 9, 15a, 17, 18a, 19b, 21, 30b, 222 and 320c, PIWIinteracting RNA36743 and GlyCCC2] in triple positive BT474 cells and three TNBC cell lines (BT20, HS578T and MDAMB231) treated with various chemotherapeutic agents using reverse transcriptionquantitative PCR. +lncRNA target 31789394 hsa-mir-21 Carcinoma, Renal Cell Overall, these findings, along with evidencebased molecular biology, demonstrated that miR21 expression promoted the migration, invasion and angiogenic abilities of RCC cells by directly targeting the PDCD4/cJun signalling pathway. +other 31789388 hsa-mir-149 Lung Neoplasms In lung cancer cells, LINC00460 promoted EGFRTKI resistance as a competitive decoy for miR1495p, thereby facilitating interleukin (IL)6 expression and inducing EMTlike phenotypes. +lncRNA target 31789385 hsa-mir-145 Esophageal Neoplasms In addition, CCAT2 negatively regulated miR145 and P70 ribosomal protein S6 kinase 1 (p70S6K1) expression, and inhibited phosphorylation of Akt, ERK and p70S6K1 in EC cells. These results showed that CCAT2 promoted the radiotherapy resistance of EC cells via negative regulation of the miR145/p70S6K1 and the p53 signaling pathways and associated elements may be potential targets for improving the sensitivity of EC radiotherapy. +other 31789347 hsa-mir-199a Reperfusion Injury, Intestinal Ischemia CONCLUSION: Collectively, miR-199a-3p may serve a key role in the anti-apoptotic mechanism of HRS that contributes to its protection of the intestine against I/R injury. +genetics_knock down_promote 31789129 hsa-mir-142 Breast Neoplasms 5p were reversed via knockdown Sorbin and SH3 domain-containing protein 1. +circulation_biomarker_prognosis_ns 31789049 hsa-mir-208b Acute Coronary Syndrome Conclusion: Circulating miR-208b and miR-499 could be considered as diagnostic or prognostic biomarkers for patients with ACS. +circulation_biomarker_prognosis_ns 31789049 hsa-mir-499 Acute Coronary Syndrome Conclusion: Circulating miR-208b and miR-499 could be considered as diagnostic or prognostic biomarkers for patients with ACS. +lncRNA target 31788970 hsa-mir-361 Carcinoma, Non-Small-Cell Lung CONCLUSION: In conclusion, LncRNA SNHG1 promoted the proliferation, repressed apoptosis and enhanced migration and invasion of NSCLC cells by regulating FRAT1 expression via sponging miR3p. +lncRNA target 31788846 hsa-mir-4500 Urinary Bladder Neoplasms Our data highlighted miR-4500 as a potent cancericidal gene in BC, and might provide a theoretical grounding for development of target-oriented therapies of patients afflicted with BC. +genetics_overexpression_promote 31788125 hsa-mir-125b Gallbladder Neoplasms In addition, the expression of miR-125b in GBC was significantly decreased, and the growth of gallbladder cancer cells was inhibited by the overexpression of miR-125b. +lncRNA target 31788123 hsa-mir-125b Multiple Myeloma In the present study it was identified that IRAIN may act as a tumor suppressor in MM, whilst microRNA (miR)-125b may promote tumorigenesis. +lncRNA target 31788114 hsa-mir-221 Myeloma Bone Disease 5p inhibition, and this increased the osteogenic differentiation capacity of MBD-MSCs. +genetics_knock down_promote 31788111 hsa-mir-203a Primary Myelofibrosis The RT-qPCR and western blot assays revealed that overexpression of smad9 significantly enhanced the effect of miR-203a-3p.1 inhibitors on osteoblast markers, which indicated that miR-203a-3p.1 inhibitors may regulate the osteogenic differentiation of MM-MSCs by upregulating Smad9. +other 31788111 hsa-mir-203a Multiple Myeloma The aim of the present study was to determine whether miR-203a-3p.1 is involved in osteogenic differentiation of multiple myeloma (MM)-mesenchymal stem cells (MSCs) and the potential underlying mechanism. +genetics_overexpression_promote 31788107 hsa-mir-141 Carcinoma, Hepatocellular miRNA-141/-582/-9 were upregulated, while miRNA-675 was downregulated in patients with McVI when compared with HCC patients without VI. In conclusion, the overexpression of miRNA-141/-582/-9 was associated with McVI and a poor survival in patients undergoing hepatic resection for HCC. +genetics_overexpression_promote 31788107 hsa-mir-582 Carcinoma, Hepatocellular miRNA-141/-582/-9 were upregulated, while miRNA-675 was downregulated in patients with McVI when compared with HCC patients without VI. In conclusion, the overexpression of miRNA-141/-582/-9 was associated with McVI and a poor survival in patients undergoing hepatic resection for HCC. +genetics_overexpression_promote 31788107 hsa-mir-9 Carcinoma, Hepatocellular miRNA-141/-582/-9 were upregulated, while miRNA-675 was downregulated in patients with McVI when compared with HCC patients without VI. In conclusion, the overexpression of miRNA-141/-582/-9 was associated with McVI and a poor survival in patients undergoing hepatic resection for HCC. +other 31788103 hsa-mir-145 Carcinoma, Non-Small-Cell Lung Therefore, silencing of LINC00707 enhanced DDP sensitivity in A549/DDP cells by sponging miR-145, thereby shedding light on LINC00707 and its corresponding molecular mechanisms involved in the progression of DDP resistance in NSCLC cells. +genetics_overexpression_promote 31788100 hsa-mir-122a Carcinoma, Hepatocellular miR-122a overexpression led to inhibited migration and invasion of HCC cells and attenuated the effects of MANCR overexpression. +lncRNA target 31788099 hsa-mir-10b Urinary Bladder Neoplasms In summary, the present study focused on the role of propofol in the treatment of bladder cancer and demonstrated that propofol may serve a tumor-suppressive role and control cell viability, migration and invasion of T24 cells by targeting the miR-10b/HOXD10 signaling pathway, which indicated that propofol may be used as an effective therapeutic drug for the treatment of bladder cancer. +circulation_biomarker_prognosis_ns 31788094 hsa-mir-129 Prostatic Neoplasms RT-qPCR was used to detect expression of serum miR-129 and miR-139. +circulation_biomarker_prognosis_ns 31788094 hsa-mir-139 Prostatic Neoplasms RT-qPCR was used to detect expression of serum miR-129 and miR-139. +other 31788089 hsa-mir-455 Glioma 3p as a promising biomarker for the prognosis of glioma. +lncRNA target 31788087 hsa-mir-100 Carcinoma, Hepatocellular 5p and these 4 potential target genes may provide novel therapeutic targets and prognostic predictors for patients with HCC. +circulation_biomarker_diagnosis_up 31788082 hsa-mir-34a Ependymoma In addition, 6 hub genes [cyclin dependent kinase 1, CD44 molecule (Indian blood group) (CD44), proliferating cell nuclear antigen (PCNA), MYC, synaptotagmin 1 (SYT1) and kinesin family member 4A] and 6 crucial miRNAs [homo sapiens (hsa)-miR-34a-5p, hsa-miR-449a, hsa-miR-106a-5p, hsa-miR +circulation_biomarker_diagnosis_up 31788082 hsa-mir-449a Ependymoma In addition, 6 hub genes [cyclin dependent kinase 1, CD44 molecule (Indian blood group) (CD44), proliferating cell nuclear antigen (PCNA), MYC, synaptotagmin 1 (SYT1) and kinesin family member 4A] and 6 crucial miRNAs [homo sapiens (hsa)-miR-34a-5p, hsa-miR-449a, hsa-miR-106a-5p, hsa-miR +circulation_biomarker_diagnosis_up 31788082 hsa-mir-128 Ependymoma In addition, 6 hub genes [cyclin dependent kinase 1, CD44 molecule (Indian blood group) (CD44), proliferating cell nuclear antigen (PCNA), MYC, synaptotagmin 1 (SYT1) and kinesin family member 4A] and 6 crucial miRNAs [homo sapiens (hsa)-miR-34a-5p, hsa-miR-449a, hsa-miR-106a-5p, hsa-miR +circulation_biomarker_diagnosis_up 31788082 hsa-mir-124 Ependymoma In addition, 6 hub genes [cyclin dependent kinase 1, CD44 molecule (Indian blood group) (CD44), proliferating cell nuclear antigen (PCNA), MYC, synaptotagmin 1 (SYT1) and kinesin family member 4A] and 6 crucial miRNAs [homo sapiens (hsa)-miR-34a-5p, hsa-miR-449a, hsa-miR-106a-5p, hsa-miR +circulation_biomarker_diagnosis_up 31788082 hsa-mir-106a Ependymoma In addition, 6 hub genes [cyclin dependent kinase 1, CD44 molecule (Indian blood group) (CD44), proliferating cell nuclear antigen (PCNA), MYC, synaptotagmin 1 (SYT1) and kinesin family member 4A] and 6 crucial miRNAs [homo sapiens (hsa)-miR-34a-5p, hsa-miR-449a, hsa-miR-106a-5p, hsa-miR +circulation_biomarker_diagnosis_up 31788082 hsa-mir-30 Ependymoma In addition, 6 hub genes [cyclin dependent kinase 1, CD44 molecule (Indian blood group) (CD44), proliferating cell nuclear antigen (PCNA), MYC, synaptotagmin 1 (SYT1) and kinesin family member 4A] and 6 crucial miRNAs [homo sapiens (hsa)-miR-34a-5p, hsa-miR-449a, hsa-miR-106a-5p, hsa-miR +genetics_overexpression_promote 31788073 hsa-mir-33a Triple Negative Breast Neoplasms miR-33a-5p overexpression significantly improved the doxorubicin (Dox) sensitivity of TNBC cells, but not that of non-TNBC cells. +genetics_knock down_promote 31788071 hsa-mir-370 Lung Neoplasms Furthermore, the knockdown of KCNK15-AS1 was performed in A549 and H460 lung cancer cells with small interfering RNA, resulting in a significant inhibition of the proliferation, a decrease in the mRNA and protein expression of cyclin D1 (CCND1) and epidermal growth factor receptor (EGFR), in addition to the phosphorylation of protein kinase B, with a concomitant increase in the expression of microRNA (miR)-202 and miR-370 compared with negative control group. +other 31788066 hsa-mir-4435-2 Glioma The long noncoding RNA (lncRNA) AWPPH, also termed microRNA2HG, has been associated with the poor prognosis of patients with hepatocellular carcinoma (HCC), and has been demonstrated to promote the progression of HCC and bladder cancer. +other 31788058 hsa-mir-135 Stomach Neoplasms In conclusion, miR-23a and miR-135 are highly expressed in gastric cancer patients and positively correlated with tumor markers, which can be used in diagnosis for gastric cancer. +genetics_knock down_promote 31787850 hsa-mir-107 Neuroblastoma Knockdown of miR-107 or overexpression of BDNF reversed the suppression of NB progression caused by DLX6-AS1 silence. +other 31787746 hsa-mir-9 Myocardial Infarction Collectively, our data identify a novel function of lncR-TUG1/miR-9/KLF5 axis in regulating cardiomyocyte apoptosis that affects myocardial infarction progression. +transcription factor target 31786883 hsa-mir-15 Thyroid Neoplasms Additionally, the expression of Bcl-2 was also enhanced in all the thyroid cancer cells and miR-15 ectopic expression could cause suppression of the Bcl-2 expression in MDA-T35 cells. +transcription factor target 31786874 hsa-mir-299 Nasopharyngeal Carcinoma Additionally, the expression of VEGFA was enhanced in all NC cells and miR-299 ectopic expression could cause suppression of the VEGFA expression in HK1 cells. +genetics_overexpression_promote 31786854 hsa-mir-365 Triple Negative Breast Neoplasms The proliferation, migration and invasion abilities were suppressed by overexpression of miR-365, whereas they were enhanced by interfering miR-365 in breast cancer. +genetics_knock down_promote 31786621 hsa-mir-574 Uterine Cervical Neoplasms Knockdown of miR +transcription factor target 31786540 hsa-mir-182 Mucocutaneous Lymph Node Syndrome Furthermore, JAr spheroid attachment experiments show that attachment rates were significantly decreased after treatment of IK cells with inhibitors for miR +transcription factor target 31786540 hsa-mir-183 Mucocutaneous Lymph Node Syndrome Furthermore, JAr spheroid attachment experiments show that attachment rates were significantly decreased after treatment of IK cells with inhibitors for miR +transcription factor target 31786540 hsa-mir-96 Mucocutaneous Lymph Node Syndrome Furthermore, JAr spheroid attachment experiments show that attachment rates were significantly decreased after treatment of IK cells with inhibitors for miR +other 31786295 hsa-mir-107 Osteonecrosis The present study showed that low level of miR-107 in femoral head tissues from rats suffering steroid-induced osteonecrosis of the femoral head (SANFH) was associated with high degree of osteonecrosis and apoptosis. +other 31786295 hsa-mir-107 Femur Head Necrosis The present study showed that low level of miR-107 in femoral head tissues from rats suffering steroid-induced osteonecrosis of the femoral head (SANFH) was associated with high degree of osteonecrosis and apoptosis. +lncRNA target 31785262 hsa-mir-31 Intracranial Aneurysm 3p maintains the contractile type of VSMCs, thus possibly inhibiting the progression of IA. +transcription factor target 31785072 hsa-mir-7 Prostatic Hyperplasia The inhibitory function of icariin in cell model of benign prostatic hyperplasia by upregulation of miR-7. +genetics_GWAS 31785027 hsa-mir-149 Mucocutaneous Lymph Node Syndrome CONCLUSION: Our results indicated that in southern Chinese patients, the miRNA-149 rs2292832 T>C polymorphism did not affect KD susceptibility, which needs to be further confirmed. +lncRNA target 31784954 hsa-mir-216a Acute Lung Injury Silencing of JAK2 partially aggravated miR-216a-inhibited inflammation injury. In conclusion, miR-216a alleviates LPS-induced inflammatory injury via regulating JAK2/STAT3 and NF-kappaB signaling. +other 31784757 hsa-mir-122 Hepatitis C CONCLUSIONS: HCV infection may induce thyroid dysfunction by different mechanisms including direct infection of thyrocytes leading to activation of inflammatory pathways and upregulation of miR-122. +circulation_biomarker_diagnosis_up 31784323 hsa-mir-92a Cholangiocarcinoma Bile-derived circulating extracellular miR-30d-5p and miR-92a-3p are potential biomarkers for discriminating CCA from BBD. +exosome 31783913 hsa-mir-644 Fibrous Dysplasia, Polyostotic 5p carried by BMSC-derived exosomes inhibited the apoptosis of ovarian granulosa cell by targeting p53 of cells, suggesting that miR +lncRNA target 31783879 hsa-mir-138 Lung Neoplasms CONCLUSIONS: These data identified the RvD1/miR5p/FOXC1 pathway as a novel mechanism by DHA and its metabolite, RvD1, and the potential of targeting such pathway as a therapeutic strategy in treating NSCLC. +lncRNA target 31783700 hsa-mir-9 Colorectal Neoplasms In conclusion, CDX2, the post-transcriptional target of microRNA +other 31783671 hsa-mir-19b Meningitis, Escherichia coli Moreover, in vivo injection of miR-19b-3p mimics during meningitic E. These in vivo and in vitro findings indicate a novel quenching mechanism of the host by attenuating miR-19b-3p/TNFAIP3/NF-kappaB signaling in BMECs in response to meningitic E. +lncRNA target 31782983 hsa-mir-1301 Urinary Bladder Neoplasms These data suggested that NNT-AS1 enhances BC cell growth and activates Wnt pathway by targeting miR +lncRNA target 31782911 hsa-mir-199a Nasopharyngeal Carcinoma METHODS: The expressions of DLX6-AS1, miR-199a-5p, and HIF-1alpha mRNA in NPC issues and cells were detected by qRT-PCR. CONCLUSION: We found that DLX6-AS1 was a cancer-promoting lncRNA to facilitate the progression of NPC, and its underlying mechanism was suppressing miR-199a-5p expression. +circRNA target 31782868 hsa-mir-296 Carcinoma, Renal Cell 5p inhibitor. +other 31782762 hsa-mir-499 Coronary Artery Disease Thus, miR-21, miR-133, and miR-499 appear to have the most potential as biomarkers to differentiate the diagnosis of ACS from stable CAD, especially miR-499 which showed a correlation between the level of their concentration gradient and myocardial damage. +other 31782762 hsa-mir-499 Acute Coronary Syndrome Thus, miR-21, miR-133, and miR-499 appear to have the most potential as biomarkers to differentiate the diagnosis of ACS from stable CAD, especially miR-499 which showed a correlation between the level of their concentration gradient and myocardial damage. +lncRNA target 31782506 hsa-mir-125 Colorectal Neoplasms The present study shows that miR-125 suppresses CRC proliferation and invasion by targeting TAZ. +circulation_biomarker_diagnosis_ns 31782176 hsa-mir-192 Non-alcoholic Fatty Liver Disease Serum exosomal miR +other 31781973 hsa-mir-34a Celiac Disease The expression level of miR-34a-5p and JAG1 were detected in CA tissues and HPV-HaCaT cells. The results showed that miR-34a-5p expression was decreased, and JAG1 expression was increased in CA tissues and HPV-HaCaT cells. +transcription factor target 31781973 hsa-mir-34a Papillomavirus Infections miR-34a-5p could inhibit cell development, and regulate the activity of Notch1 pathway through targeting JAG1 expression in HPV-infected keratinocytes. +circulation_biomarker_diagnosis_up 31781909 hsa-mir-125b Celiac Disease RESULTS: Expression levels of miRNA-146a, miRNA-155, and miRNA-21 in PBMCs, miRNA-155 in monocytes and miRNA-155, miRNA-21, and miRNA-125b in plasma were elevated in both groups of celiac patients. +circulation_biomarker_diagnosis_up 31781909 hsa-mir-21 Celiac Disease RESULTS: Expression levels of miRNA-146a, miRNA-155, and miRNA-21 in PBMCs, miRNA-155 in monocytes and miRNA-155, miRNA-21, and miRNA-125b in plasma were elevated in both groups of celiac patients. +circulation_biomarker_diagnosis_up 31781909 hsa-mir-155 Celiac Disease AIMS: We evaluated inflammation-related miRNA-146a, miRNA-155, miRNA-21, and miRNA-125b expression in peripheral blood and intestinal mucosa of CD adults. +circulation_biomarker_diagnosis_up 31781909 hsa-mir-146a Celiac Disease AIMS: We evaluated inflammation-related miRNA-146a, miRNA-155, miRNA-21, and miRNA-125b expression in peripheral blood and intestinal mucosa of CD adults. +circulation_biomarker_diagnosis_up 31781865 hsa-mir-199b Rectal Neoplasms Also, upregulated exosomal miR-199b-5p correlated with CRT response, reflecting its promise as a circulating biomarker of CRT response in patients with LARC. +other 31781865 hsa-mir-199a Rectal Neoplasms High expression of microRNA-199a-5p is associated with superior clinical outcomes in patients with locally advanced rectal cancer. +other 31781574 hsa-mir-4274 Breast Neoplasms, Basal Cell LAMA4-regulating miRNA miR-4274 and its host gene SORCS2 were highlighted as intermediate regulators of the expression levels of LAMA4, which correlated in a basal-like breast carcinoma sample subset of TCGA to the levels of SORCS2 negatively. +lncRNA target 31781561 hsa-mir-193a Hepatoblastoma This study aimed to identify the role of ZFAS1/miR-193a-3p/RALY axis in the development of HB. Collectively, these data demonstrated that ZFAS1 acted as an oncogene to promote initiation and progression of HB by regulating miR-193a-3p/RALY (RALY Heterogeneous Nuclear Ribonucleoprotein) axis via HGF/c-Met Pathway, which provides an efficient marker and new therapeutic target for HB. +lncRNA target 31781497 hsa-mir-4656 Breast Neoplasms Finally, we identified that Huaier could inhibit the proliferation of breast cancer cells through modulating linc00339/miR-4656/CSNK2B signaling pathway. +circRNA target 31781492 hsa-mir-1229 Colorectal Neoplasms Conclusions: Our data suggested that the hsa_circ_00001666/has-mir-1229/CXCR5 axis plays an important role in the pathogenesis of CRC, thereby identifying a potential therapeutic target. +lncRNA target 31781322 hsa-mir-200a Cardiotoxicity In conclusion, miR-200a protected against DOX-induced cardiotoxicity via activation of the Nrf2 signaling pathway. +other 31781304 hsa-mir-4669 Ischemic Stroke Our pilot study showed a weak association of rs79402775 in miRNA-933 (p = 0.044) and a relatively strong association of rs35196866 in miRNA-4669 (p = 0.016) with IS. These results suggest that miRNA-4669 may be involved in the susceptibility of IS. +circulation_biomarker_diagnosis_ns 31781298 hsa-mir-499 Myocardial Infarction In addition, this analysis suggests that plasma levels of circulating miR-499 could contribute to the identification of patients at increased risk of death during the first year after AMI, especially when combined with NT-proBNP levels. +genetics_knock down_promote 31781245 hsa-mir-34a Osteosarcoma DNMT1 knockdown increased miR-34a and reduced the stemness of OSLCs. +circulation_biomarker_diagnosis_ns 31781210 hsa-mir-129 Obesity Importantly, the aforementioned results suggest serum miR +lncRNA target 31781203 hsa-mir-130b Diabetic Nephropathies Objective To investigate the role of microRNA-130b in 1,25(OH)2D3 mediated improvement of renal fibrosis via transforming growth factor-beta 1 in a rat model of diabetic nephropathy (DN). Moreover, miR-130b may be involved in the protective effect of 1,25(OH)2D3 on renal fibrosis via TGF-1. +other 31780861 hsa-mir-23b Autoimmune Diseases MicroRNA- (miR-) 23b has emerged as an anti-inflammatory factor that prevents multiple autoimmune diseases. +circulation_biomarker_diagnosis_down 31780861 hsa-mir-23b Sepsis RESULTS: miR-23b expression was downregulated in the peripheral blood mononuclear cells of sepsis patients and LPS-induced THP-1 cells and was negatively correlated with the expression of ADAM10 and inflammatory cytokines. +other 31780396 hsa-mir-615 Squamous Cell Carcinoma of Head and Neck INTERPRETATION: A three-miRNA signature of hsa-mir-383, hsa-mir-615, and hsa-mir-877 may serve as an excellent diagnostic biomarker for HNSCC, and potential prognostic significance for HNSCC patients. +other 31780396 hsa-mir-383 Squamous Cell Carcinoma of Head and Neck INTERPRETATION: A three-miRNA signature of hsa-mir-383, hsa-mir-615, and hsa-mir-877 may serve as an excellent diagnostic biomarker for HNSCC, and potential prognostic significance for HNSCC patients. +other 31780396 hsa-mir-877 Squamous Cell Carcinoma of Head and Neck INTERPRETATION: A three-miRNA signature of hsa-mir-383, hsa-mir-615, and hsa-mir-877 may serve as an excellent diagnostic biomarker for HNSCC, and potential prognostic significance for HNSCC patients. +epigenetics 31780284 hsa-mir-7 Emphysema CONCLUSION: The increase of miR-7 methylation levels experienced by COPD patients occurs mainly at the expense of the emphysema phenotype, which might contribute to explain the higher incidence of lung cancer in these patients. +lncRNA target 31779647 hsa-mir-23b Osteosarcoma The inhibition of miR-23b-3p obviously promoted cell viability, proliferation, and cell cycle progression but reduced apoptosis rate of MG-63 cells; however, the treatment of GW4064 could partially reverse the effects of the inhibition of miR-23b-3p on OS cells. +other 31779616 hsa-mir-4715 Lung Neoplasms CONCLUSIONS: LCAT1-miR5p-RAC1/PAK1 axis plays an important role in the progression of lung cancer. +other 31779593 hsa-mir-383 Uterine Cervical Neoplasms 5p to release SFN. +lncRNA target 31779271 hsa-mir-6764 Arthritis, Juvenile The combination of miR5p, miR-155, and miR-146a-5p expression in synovial fluid yielded an area under the receiver operating characteristic curve of 1 (95% CI 0.978 to 1), thereby perfectly differentiating JIA from SA in children. +lncRNA target 31779271 hsa-mir-146a Arthritis, Juvenile The combination of miR5p, miR-155, and miR-146a-5p expression in synovial fluid yielded an area under the receiver operating characteristic curve of 1 (95% CI 0.978 to 1), thereby perfectly differentiating JIA from SA in children. +lncRNA target 31779271 hsa-mir-155 Arthritis, Juvenile The combination of miR5p, miR-155, and miR-146a-5p expression in synovial fluid yielded an area under the receiver operating characteristic curve of 1 (95% CI 0.978 to 1), thereby perfectly differentiating JIA from SA in children. +lncRNA target 31778958 hsa-mir-145 Endometrial Hyperplasia We deem that intervention in the circDcbld1-miR3p/Nrp1 pathway might be a feasible approach to alleviate the post-injury intimal hyperplasia. +other 31778928 hsa-mir-605 Li-Fraumeni Syndrome Recently, the functional MIR605 variant rs2043556 (A>G) has been identified as a novel LFS phenotype modifier in families with germline TP53 DNA binding variants. +genetics_knock down_suppress 31778769 hsa-mir-27a Spinal Cord Injuries As a result, we observed higher level of XIST and Smurf1, but lower level of miR-27a in SCI rats and lipopolysaccharide (LPS)-induced primary microglial cells. Collectively, knockdown of XIST could alleviate the apoptosis and inflammatory injury of SCI models in vitro and in vivo through directly modulating miR-27a/Smurf1 axis. +other 31778754 hsa-mir-582 Teratozoospermia 5p in regulation of CRISP2 expression in teratoasthenozoospermia individuals. +other 31778754 hsa-mir-582 Asthenozoospermia 5p in regulation of CRISP2 expression in teratoasthenozoospermia individuals. +circulation_biomarker_diagnosis_up 31778754 hsa-mir-582 Infertility The aim of this study was to determine the expression of CRISP2 and mir-582 in the seminal plasma fluid and spermatozoa of three groups of infertile men and the possible association of their expressions. +transcription factor target 31778666 hsa-mir-107 Alzheimer Disease The expression of miR-107 is down-regulated in AD patients and target genes of miR-107 have been shown to directly involved in AD. Our findings confirm that miR-107 may be involved in AD pathogenesis and may be a therapeutic target for the treatment of AD-related impairments. +circulation_biomarker_prognosis_ns 31778243 hsa-mir-21 Sepsis Furthermore, miR-21 expression was negatively correlated with serum creatinine, C-reactive protein, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and IL-17, while positively correlated with albumin in sepsis patients. +circulation_biomarker_prognosis_ns 31778243 hsa-mir-21 Inflammation Furthermore, miR-21 expression was negatively correlated with serum creatinine, C-reactive protein, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and IL-17, while positively correlated with albumin in sepsis patients. +lncRNA target 31778188 hsa-mir-24 Carcinoma, Non-Small-Cell Lung 5p upregulation mediates, at least partially, the CDDP resistance by directly targeting FBXO11 signalling in LCa cells. +circRNA target 31778020 hsa-mir-149 Esophageal Squamous Cell Carcinoma In summary, circ_0000654 functions as an oncogenic circRNA in ESCC and accelerates ESCC progression via adsorbing miR +exosome 31777597 hsa-mir-17 Nasopharyngeal Carcinoma Conclusions: Our study showed that exosomal miR +lncRNA target 31777593 hsa-mir-125a Carcinoma, Hepatocellular Methods: Quantitative reverse transcriptase PCR (qPCR) was used to assess expression of MALAT1, Forkhead Box M1 (FOXM1) and miR-125a-3p in HCC tissue samples. Conclusions: These results indicate that MALAT1 modulates FOXM1 expression via being a miR-125a-3p sponge, thus promoting HCC progression. +genetics_overexpression_promote 31777550 hsa-mir-652 Esophageal Squamous Cell Carcinoma Furthermore, restoring FGFR1 expression abolished the suppressive effects of miR-652 overexpression on the proliferation and invasion of ESCC cells. +circulation_biomarker_diagnosis_ns 31777547 hsa-mir-106b Epilepsy Efficacy of levetiracetam (LEV) combined with sodium valproate (SV) on pediatric epilepsy and its effect on serum miR-106b in children were investigated. According to the ROC curve analysis, when the cut-off value was 1.442, the sensitivity, specificity and area under curve (AUC) of miR-106b in the diagnosis of pediatric epilepsy were 94.00, 64.17 and 0.833 respectively. +lncRNA target 31777535 hsa-mir-34a Osteoarthritis Finally, miR-34a-5p and miR-181a-5p were predicted and subsequently verified to directly target the 3'-untranslated region of the GAS1 gene, downregulating GAS1 levels in OASFs and IL-1beta-induced SFs. In conclusion, the present study demonstrated that downregulation of GAS1 can lead to the hyperproliferation of SFs in OA pathogenesis through the PI3K-Akt pathway, and miR-34a-5p and miR-181a-5p are potential regulators of GAS1 expression in OA. +lncRNA target 31777535 hsa-mir-181a Osteoarthritis Finally, miR-34a-5p and miR-181a-5p were predicted and subsequently verified to directly target the 3'-untranslated region of the GAS1 gene, downregulating GAS1 levels in OASFs and IL-1beta-induced SFs. In conclusion, the present study demonstrated that downregulation of GAS1 can lead to the hyperproliferation of SFs in OA pathogenesis through the PI3K-Akt pathway, and miR-34a-5p and miR-181a-5p are potential regulators of GAS1 expression in OA. +genetics_GWAS 31777500 hsa-mir-196a Breast Neoplasms Conclusions Our results demonstrate that miR-196a rs11614913 C/T polymorphism is associated with a decreased risk and loss of protein expression in breast cancer in the Pakistani population. +lncRNA target 31777264 hsa-mir-138 Glioma Meanwhile, HIF-1alpha was also a target of miR-138 and miR-138 could also regulate the proliferation, migration and angiogenesis of glioma cells by targeting HIF-1alpha and affecting the expression of VEGF in turn. Our findings identified an upregulated lncRNA H19 in glioma cells, which could promote proliferation, migration, invasion and angiogenesis via miR-138/HIF-1alpha axis as a ceRNA. +genetics_GWAS 31777261 hsa-mir-636 Carcinoma, Hepatocellular These data suggest that the rs34000982 polymorphism may contribute to HCC susceptibility, in full or at least partially through the effect on HMGB1 transcriptional activity by disturbing the binding of miR-636 with the 3'UTR of HMGB1. +genetics_overexpression_suppress 31777195 hsa-mir-34a Carcinoma, Non-Small-Cell Lung METHODS: The expression of miR-34a, Axl, Gas6 and related downstream signaling proteins in the EGFR mutant NSCLC cell lines were determined by qRT-PCR and Western blot; PC9-Gef-miR-34a and HCC827-Gef-miR-34a cells were established by transfecting the parent cells with a miR-34a overexpressing virus, then the expression of Axl, Gas6 and the downstream channel-related proteins were also compared in PC9-Gef-miR-34a and HCC827-Gef-miR-34a and drug-resistant strains. +other 31777165 hsa-mir-16 Myocarditis The purpose of this study was to investigate the biological effect of miR-16 on myocarditis and the underlying molecular mechanism. Cells cotransfected with miR-16 mimic and si-CD40 could significantly abolish the injury of cardiomyocytes caused by myocarditis. +genetics_knock down_suppress 31776854 hsa-mir-340 Carcinoma, Hepatocellular In conclusion, our findings demonstrated that MYCNOS knockdown inhibited HCC progression through regulating miR-340. +circulation_biomarker_prognosis_ns 31776711 hsa-mir-145 Stomach Neoplasms 5p in the cytoplasm, and acted as a sponge of miR +genetics_overexpression_promote 31776419 hsa-mir-1 Uterine Cervical Neoplasms Thus, silencing Sema4C or overexpression of miR +genetics_overexpression_promote 31776329 hsa-mir-28 Carcinoma, Hepatocellular Moreover, circRNA-5692 overexpression inhibited the growth of xenograft HCC tumors in vivo by decreasing miR +transcription factor target 31776299 hsa-mir-378a Myopia Moreover, CHRM2 may be a target of myopia-absent miRNA (has-miR-378a-5p). +exosome 31775815 hsa-mir-124 Esophageal Squamous Cell Carcinoma CONCLUSION: This study highlights that exosomal ZFAS1 promotes the proliferation, migration and invasion of ESCC cells and inhibits their apoptosis by upregulating STAT3 and downregulating miR-124, thereby resulting in the development of tumorigenesis of ESCC. +other 31775784 hsa-mir-204 Apparent mineralocorticoid excess 5p (fold-change=0.246; p 0.03) are both significantly downregulated in NC-AME. +other 31775784 hsa-mir-192 Apparent mineralocorticoid excess 5p (fold-change=0.246; p 0.03) are both significantly downregulated in NC-AME. +circulation_biomarker_diagnosis_down 31775690 hsa-mir-34a Pulmonary Disease, Chronic Obstructive RESULTS: miR-34a was down-regulated in COPD- BS vs COPD-TS. Moreover, the serum concentration of Notch1, one of the targets of miR-34a, was increased in COPD-BS compared to women with COPD-TS. +circulation_biomarker_diagnosis_up 31775542 hsa-mir-191 Kidney Diseases In this study, we measured the expression levels of miR-191 in plasma, the contents of pro-inflammatory (interleukin (IL)-6 and tumor necrosis factor alpha) and anti-inflammatory (IL-2 and transforming growth factor beta) cytokines, and renal dysfunction indicators (blood urea nitrogen, blood creatinine, uric acid, and cystatin C) in serum from control and arsenic poisoning populations and analyzed the relationship between the miR-191, cytokines, and renal dysfunction indicators. +transcription factor target 31775315 hsa-mir-665 Multiple Sclerosis miR-665 and ELL3 turned out to be the main targets of MS myelin-specific lymphocytes. +exosome 31775160 hsa-mir-223 Psychotic Disorders Using mature miRNA profiling and quantitative real-time PCR (qRT-PCR) in the orbitofrontal cortex (OFC) of SCZ (N=29; 20 male and 9 female), BD (N=26; 12 male and 14 female), and unaffected control (N=25; 21 male and 4 female) subjects, we uncovered that miR-223, an exosome-secreted miRNA that targets glutamate receptors, was increased at the mature miRNA level in the OFC of SCZ and BD patients with positive history of psychosis at the time of death and was inversely associated with deficits in the expression of its targets glutamate ionotropic receptor NMDA-type subunit 2B (GRIN2B) and glutamate ionotropic receptor AMPA-type subunit 2 (GRIA2). +lncRNA target 31774554 hsa-mir-3175 congenital myopathy 1A Since MiR-3175 is upregulated in pterygium tissues compared to normal conjunctival tissues, in this study, we investigated the role of MiR-3175 in EMT of a cultured human conjunctival epithelium cell line (CCL) and further validated the findings in pterygium tissues from patients. Our study demonstrates that MiR-3175 promotes proliferation, migration, invasion, and EMT of CCL cells by directly inhibiting Smad7. +other 31774373 hsa-mir-206 Pneumonia, Mycoplasma Together, these results suggest that MALAT1 and miR-206 play important roles in PE. +circulation_biomarker_diagnosis_down 31773791 hsa-mir-133a Pancreatic Carcinoma Serum miR-133a could function as a potential diagnostic indicator for pancreatic cancer. +other 31773709 hsa-mir-135a Pulmonary Arterial Hypertension OBJECTIVE: The aim of this study was to investigate the regulatory role of micro-ribonucleic acid (miR)-135a in monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) in rats, and to analyze the possible regulatory mechanism. +genetics_knock down_promote 31773706 hsa-mir-200a Respiratory Distress Syndrome, Newborn The mRNA and protein expression levels of beta-catenin and IL-10 in newborn RDS rabbits with miR-200a over-expression and knockout were detected as well. +genetics_overexpression_suppress 31773704 hsa-mir-155 Melanoma Additionally, CBL was negatively associated with miR-155 in malignant melanoma and overexpression of CBL attenuated miR +lncRNA target 31773703 hsa-mir-93 Glioma 5p in glioma by targeting MMP2, thus providing some novel experimental basis for the treatment of glioma. +genetics_knock down_promote 31773700 hsa-mir-130 Adenocarcinoma of Lung 5p knockdown enhanced the activity of lung cancer cells and promoted cancer cell invasion as well as migraindicated confirmed that microRNA +lncRNA target 31773699 hsa-mir-143 Carcinoma, Hepatocellular In addition, circ_0000064 significantly promoted proliferation and inhibited apoptosis of hepatocellular carcinoma cells via modulating microRNA-143. +lncRNA target 31773695 hsa-mir-505 Colorectal Neoplasms However, the down-regulation of LEF-AS1 reduces the proliferation rate and suppresses the invasiveness and metastasis of CRC cells through the LEF-AS1/miR-505/KIF3B axis. +genetics_overexpression_promote 31773692 hsa-mir-28 Carcinoma, Hepatocellular In the cell reverse experiment, the overexpression of MMP-9 could counteract the influence of the overexpressed microRNA +genetics_overexpression_promote 31773690 hsa-mir-135 Stomach Neoplasms The cell recovery study found that overexpression of SMAD2 can offset the influence of microRNA-135 mimics on proliferation and metastasis of GC cells, thus affecting the malignant progression of GC. +lncRNA target 31773689 hsa-mir-145 Stomach Neoplasms CONCLUSIONS: Circ-ZNF609 promotes proliferative and invasive abilities of gastric cancer cells by inhibiting miRNA5p expression as a ceRNA, thus accelerating gastric cancer progression. +transcription factor target 31773685 hsa-mir-140 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: MiR-140 can inhibit the invasion and migration of NSCLC cells by regulating Smad3, and it is expected to become a potential clinical target. +lncRNA target 31773684 hsa-mir-579 lung squamous cell carcinoma 3p mimics significantly reduced the protein expression level of MSR1 in cells, eventually inhibiting the proliferation, invasion, and migration of SCLC cells. +other 31773676 hsa-mir-142 Leukemia, Myeloid, Acute Circ-0004136 was significantly upregulated in pediatric AML and could promote cell proliferation by sponging miR-142. +lncRNA target 31773675 hsa-mir-31 Multiple Myeloma CONCLUSIONS: UCA1 accelerates proliferation and suppresses apoptosis in MM by targeting miR +lncRNA target 31773674 hsa-mir-146a Arthritis, Gouty CONCLUSIONS: MiR-146a alleviates joint inflammation of acute arthritis in rats through the TLR4/MyD88/NF-kappaB signaling pathway, which may become a new therapeutic target. +lncRNA target 31773673 hsa-mir-93 Osteoarthritis 5p/Cyclin D1 (CCND1) axis, thereby finding new therapeutic targets for the treatment of OA. +lncRNA target 31773671 hsa-mir-7b Osteoporosis OBJECTIVE: To elucidate whether microRNA-7b-5p (miRNA-7b-5p) could inhibit adipose differentiation of human bone marrow-derived mesenchymal stem cells (hMSCs) through regulating IRS2, thereby alleviating the progression of osteoporosis. CONCLUSIONS: MiRNA-7b-5p inhibits the adipogenic differentiation of hMSCs through IRS2, thus alleviating the development of osteoporosis. +other 31773667 hsa-mir-411 Diabetic Retinopathy OBJECTIVE: The aim of this study was to explore the role of microRNA-411 in diabetic retinopathy (DR) and to further understand its mechanism of action. CONCLUSIONS: MicroRNA-411 was down-regulated in the rat model of diabetic retinopathy and played a protective role in this disease, which might be achieved by negatively regulating the expression level of ROBO4. +circulation_biomarker_prognosis_ns 31772686 hsa-mir-143 Critical Illness CONCLUSION: Low miR-143 serum levels are indicative for an unfavorable short- and long-term prognosis in critically ill patients admitted to a medical ICU. +genetics_overexpression_promote 31772674 hsa-mir-105 Carcinoma, Non-Small-Cell Lung Moreover, in vivo assays verified the overexpression of LINC00261 could suppress formation of NSCLC and regulate the expression of miR-105/FHL1 axis. Conclusions: These results indicate that LINC00261 could suppress metastasis and proliferation of NSCLC via suppressing miR-105/FHL1 axis, which may offer a new vision for interpreting the mechanism of NSCLC development. +other 31772663 hsa-mir-509-2 gastric adenocarcinoma 2) were recognized as prognostic and used for the construction of a STAD prognostic signature. +other 31772663 hsa-mir-3917 gastric adenocarcinoma 2) were recognized as prognostic and used for the construction of a STAD prognostic signature. +other 31772663 hsa-mir-6511b-1 gastric adenocarcinoma 2) were recognized as prognostic and used for the construction of a STAD prognostic signature. +other 31772663 hsa-mir-138-2 gastric adenocarcinoma 2) were recognized as prognostic and used for the construction of a STAD prognostic signature. +other 31772663 hsa-mir-605 gastric adenocarcinoma 2) were recognized as prognostic and used for the construction of a STAD prognostic signature. +other 31772663 hsa-mir-495 gastric adenocarcinoma 2) were recognized as prognostic and used for the construction of a STAD prognostic signature. +other 31772663 hsa-mir-653 gastric adenocarcinoma 2) were recognized as prognostic and used for the construction of a STAD prognostic signature. +other 31772663 hsa-mir-2115 gastric adenocarcinoma 2) were recognized as prognostic and used for the construction of a STAD prognostic signature. +other 31772663 hsa-mir-145 gastric adenocarcinoma 2) were recognized as prognostic and used for the construction of a STAD prognostic signature. +other 31772663 hsa-mir-137 gastric adenocarcinoma 2) were recognized as prognostic and used for the construction of a STAD prognostic signature. +other 31772663 hsa-mir-1292 gastric adenocarcinoma 2) were recognized as prognostic and used for the construction of a STAD prognostic signature. +circulation_biomarker_diagnosis_up 31772631 hsa-mir-133a Atherosclerosis Matrix metallopeptidase-9 (MMP-9) was revealed to be a direct target gene of miR-133a-3p, which was upregulated in the blood and vascular plaque tissue of patients with AS. +genetics_overexpression_promote 31772330 hsa-mir-200a Urinary Bladder Neoplasms Taken together, the studies here showed that miR-200a overexpression inhibited Dicer expression, in turn, resulted in inhibition of miR-16 maturation, leading to upregulation of JNK2 expression, c-Jun phosphorylation, MMP-2 transcription and, ultimately, BC invasion. +other 31772242 hsa-mir-133 Behcet Syndrome The level of miR-133 was found to be increased in BDFN group in F1 generation however; in F2 generation the change in expression was tissue and sex-specific. +genetics_GWAS 31771390 hsa-mir-148 Oropharyngeal Neoplasms Our data demonstrate a modulation of PXR/NR1I2 and ABCB1 expression in OPSCC by miR-148a, however the effect was not uniform in all cell lines and depended on the range of expression of miR-148 and the genotype of rs1054190 SNP in NR1I2 3'UTR. +genetics_GWAS 31771390 hsa-mir-148a Oropharyngeal Neoplasms Our data demonstrate a modulation of PXR/NR1I2 and ABCB1 expression in OPSCC by miR-148a, however the effect was not uniform in all cell lines and depended on the range of expression of miR-148 and the genotype of rs1054190 SNP in NR1I2 3'UTR. +transcription factor target 31771219 hsa-mir-133b Carcinoma, Renal Cell Moreover, miR-133b modulated the 3'untranslated region (UTR) of MMP-9 promoter activities and subsequently the migratory and invasive abilities of these dysregulated expressions of MTA2 in RCC cells. The inhibition of MTA2 could contribute to human RCC metastasis by regulating the expression of miR-133b targeting MMP-9 expression. +circulation_biomarker_prognosis_ns 31771047 hsa-mir-216b Carcinoma, Non-Small-Cell Lung CONCLUSIONS: Collectively, serum exosomal miR-216b might be used as a potential diagnostic and prognostic biomarker for NSCLC. +genetics_overexpression_promote 31771046 hsa-mir-425 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: Overexpression of miR +other 31771042 hsa-mir-210 Carcinoma, Renal Cell 3p as powerful non-invasive prognostic and predictive biomarker for the evaluation of clinical outcomes and treatment response during ccRCC follow up. +other 31770672 hsa-mir-130b Hyperlipidemias In vivo, the reduction of lnc-HC expression significantly decreases miR-130b-3p expression, induces PPARgamma expression, and increases TG concentration in rat livers with hyperlipidemia. +other 31770533 hsa-mir-106a Cleft Palate RESULTS: The expression of miR-106a-5p increased in cleft palatal tissue and negatively correlated with the protein level of Tgfbr2. +genetics_knock down_promote 31770435 hsa-mir-17 Uveal melanoma Gain- and loss-of-function studies elucidated that silencing of lncRNA PVT1 or overexpression of miR +circulation_biomarker_diagnosis_down 31770330 hsa-mir-155 Intervertebral Disc Degeneration CONCLUSION: Serum miR5p is significantly downregulated in patients with DDD and may be a diagnostic marker for degenerative spinal disease. +circulation_biomarker_diagnosis_down 31770107 hsa-mir-98 Glioma 5p) and cytoplasmic polyadenylation element binding (CPEB4) expression in glioma tissues were tested. +circulation_biomarker_diagnosis_down 31770107 hsa-mir-98 Carcinoma, Non-Small-Cell Lung 5p) and cytoplasmic polyadenylation element binding (CPEB4) expression in glioma tissues were tested. +lncRNA target 31769911 hsa-mir-199a Aortic Aneurysm, Abdominal These findings unmasked that the pro-apoptosis impact of LUCAT1 in SMCs via directly targeting miR-199a-5p to elevate MYRF expression, which may provide valuable information on AAA prevention. +transcription factor target 31769563 hsa-mir-22 Periodontitis miR3p is a new target either for the treatment of periodontitis or the improvement of inflammation caused by orthodontics. +other 31769519 hsa-mir-215 Hepatitis C A maximum reduction in miR-215 was observed in HCC patients compared with cirrhotic and control ones. Our data stressed on the potential role of miR-215 as an important mediator in HCC progression. +lncRNA target 31769353 hsa-mir-195 Pancreatic Carcinoma Collectively, our study showed that BRAF-activated noncoding RNA promotes pancreatic cancer tumorigenesis through miR5p/Wnt/beta-catenin axis may serve as a potential target for diagnostics and therapeutics in pancreatic cancer. +genetics_overexpression_suppress 31769245 hsa-mir-338 Ovarian Neoplasms Furthermore, overexpression of miR +lncRNA target 31769229 hsa-mir-135a Urinary Bladder Neoplasms In conclusion, this study firstly suggests that MBNL1-AS1 acts as a tumor suppressor of BC by targeting miR-135a/PHLPP2/FOXO1 axis, providing a novel insight for BC diagnosis and treatment. +lncRNA target 31769216 hsa-mir-23a Carcinoma, Hepatocellular MiR-23a was decreased, whereas p65, CCL22, and Foxp3 were increased in HBV(+) tumors. Targeting p65/miR-23a/CCL22 axis was a novel approach for HBV(+) HCC treatment. +lncRNA target 31769216 hsa-mir-23a Hepatitis B MiR-23a was decreased, whereas p65, CCL22, and Foxp3 were increased in HBV(+) tumors. Targeting p65/miR-23a/CCL22 axis was a novel approach for HBV(+) HCC treatment. +genetics_overexpression_promote 31769193 hsa-mir-498 Colorectal Neoplasms However, Bcl-2 overexpression suppressed the proapoptosis of miR-498 on CRC cells. +other 31768762 hsa-let-7d Potocki-Shaffer syndrome Expression of miR-let-7d-3p was negatively correlated with the expression of IL-17 in patients with pSS. +lncRNA target 31768762 hsa-let-7d Autoimmune Diseases Our study revealed novel mechanism that how did IL-17 was exactly modulated by miR-let-7d-3p and the potential of miR-let-7d-3p-AKT1-mTOR-IL-17 signaling as therapeutic targets for autoimmune diseases. +exosome 31768526 hsa-mir-505 Atherosclerosis In summary, exosome-encapsulated miR-505 from ox-LDL-treated VECs aggravates AS by inducing NET formation. +genetics_knock down_promote 31768131 hsa-mir-373 Carcinoma, Renal Cell 3p, Dickkopf-1 (DKK1) and tissue inhibitor of metalloproteinase-2 (TIMP2), were positively regulated by lncRNA-LET in ccRCC cells. +genetics_overexpression_promote 31768130 hsa-mir-1269 Stomach Neoplasms Overexpression of RASSF9 reversed the effects of miR-1269 overexpression on GC cells. +other 31768018 hsa-mir-708 Leukemia, Myeloid, Acute We identified miR-708 to be upregulated in Hoxa9/Meis1 AML inducing cell lines as well as in AML patients. +lncRNA target 31767859 hsa-mir-155 Allergic Inflammation These findings suggest new therapeutic strategies that target miR +lncRNA target 31767835 hsa-mir-22 Adenocarcinoma of Lung In summary, current study elucidated that circ-ENO1 promoted glycolysis and tumor progression in LUAD by miR3p/ENO1 axis, indicating circ-ENO1 as a promising treatment target for LUAD patients. +lncRNA target 31767833 hsa-mir-924 Pancreatic Carcinoma Furthermore, we found that high expression levels of LINC01111 upregulated DUSP1 levels by sequestering miR-3924, resulting in the blockage of SAPK phosphorylation and the inactivation of the SAPK/JNK signaling pathway in PC cells and thus inhibiting PC aggressiveness. Overall, these data reveal that LINC01111 is a potential diagnostic biomarker for PC patients, and the newly identified LINC01111/miR-3924/DUSP1 axis can modulate PC initiation and development. +lncRNA target 31767633 hsa-mir-224 Carcinoma, Renal Cell Lastly, our results expounded that LINC01094 exerted its tumor-promoting performance in ccRCC development through miR +lncRNA target 31766975 hsa-mir-101 Myocardial Infarction Conclusions Taken together, miR-101 plays a protective role against cardiac remodeling following MI via inactivation of the RUNX1-dependent transforming growth factor beta1/Smad family member 2 signaling pathway, proposing miR-101 and RUNX1 as potential therapeutic targets for MI. +genetics_GWAS 31766967 hsa-mir-605 Acute Coronary Syndrome We found that the miR-605 rs2043556 AG genotype significantly decreased the risk of acute myocardial infarction (odds ratio, OR = 0.13, 95%CI 0.02-0.96, P = .045) and that the rs2043556 GG genotype significantly decreased the risk of unstable angina (OR = 0.19, 95%CI 0.05-0.65, P = .008) in ACS patients receiving clopidogrel therapy for more than one year. The results demonstrate that miR-605 targets the mRNA of the CYP2B6 and P2RY12 genes, and that rs2043556 A/G polymorphisms in miR-605 modulate the mRNA and protein expression of CYP2B6 and P2RY12 differently, which may impact the effect of clopidogrel in ACS patients. +other 31766887 hsa-mir-29b Atrial Fibrillation 3p) may act as novel biomarkers for AF. +other 31766887 hsa-mir-223 Atrial Fibrillation 3p) may act as novel biomarkers for AF. +other 31766887 hsa-mir-1 Atrial Fibrillation 3p) may act as novel biomarkers for AF. +other 31766887 hsa-mir-28 Atrial Fibrillation 3p) may act as novel biomarkers for AF. +other 31766415 hsa-mir-33a Hyperlipoproteinemia Type II The impact of anti-ApoA-1 IgG on key CH regulators (SREBP2, HMGCR, LDL-R, ABCA1, and miR-33a) and foam cell formation detected by Oil Red O staining were assessed using human monocyte-derived macrophages. +other 31766385 hsa-mir-654 Hpv-Induced Warts In warts, miR-27b, miR1, miR-3654, miR-647, and miR-1914 were downregulated while miR-612 was upregulated compared to normal skin. +other 31766385 hsa-mir-24-1 Hpv-Induced Warts In warts, miR-27b, miR1, miR-3654, miR-647, and miR-1914 were downregulated while miR-612 was upregulated compared to normal skin. +other 31766385 hsa-mir-612 Hpv-Induced Warts In warts, miR-27b, miR1, miR-3654, miR-647, and miR-1914 were downregulated while miR-612 was upregulated compared to normal skin. +other 31766385 hsa-mir-1914 Hpv-Induced Warts In warts, miR-27b, miR1, miR-3654, miR-647, and miR-1914 were downregulated while miR-612 was upregulated compared to normal skin. +other 31766385 hsa-mir-27b Hpv-Induced Warts In warts, miR-27b, miR1, miR-3654, miR-647, and miR-1914 were downregulated while miR-612 was upregulated compared to normal skin. +other 31766385 hsa-mir-647 Hpv-Induced Warts In warts, miR-27b, miR1, miR-3654, miR-647, and miR-1914 were downregulated while miR-612 was upregulated compared to normal skin. +circulation_biomarker_diagnosis_ns 31766231 hsa-mir-206 Alzheimer Disease MicroRNAs Let-7b and microRNA-206 were validated at elevated levels in MCI and AD, respectively. MicroRNA-206 was increased in unprocessed plasma of AD and MCI subjects, detected by our microfluidic device. +circulation_biomarker_diagnosis_ns 31766231 hsa-mir-206 Cognitive Dysfunction MicroRNAs Let-7b and microRNA-206 were validated at elevated levels in MCI and AD, respectively. MicroRNA-206 was increased in unprocessed plasma of AD and MCI subjects, detected by our microfluidic device. +circulation_biomarker_diagnosis_ns 31766231 hsa-mir-206 Dementia, Vascular MicroRNAs Let-7b and microRNA-206 were validated at elevated levels in MCI and AD, respectively. MicroRNA-206 was increased in unprocessed plasma of AD and MCI subjects, detected by our microfluidic device. +transcription factor target 31766078 hsa-mir-563 Lung Neoplasms CONCLUSION: MiR-563 plays a tumor suppressive role in lung cancer progression via targeting oncogenic LIN28B. +genetics_knock down_promote 31765608 hsa-mir-488 Melanoma The loss of miR +lncRNA target 31765229 hsa-mir-1225 Osteosarcoma 5p functions as a tumor suppressor in osteosarcoma by targeting Sox9, thereby revealing new therapeutic targets for osteosarcoma. +other 31764853 hsa-mir-183 Colorectal Neoplasms The univariate and multivariate Cox-proportional hazard regression for all variables revealed that the nodal status, distant metastasis, miR-21, miR-141, miR-182, and miR-183 were independent prognostic markers of CRC.In conclusion, altered expressions of miR-21, miR-141, miR-182, and miR-183 in CRC varies at different stages of CRC development and may serve as potential diagnosis molecular biomarkers in Romanian patients with CRC. +other 31764853 hsa-mir-21 Colorectal Neoplasms The univariate and multivariate Cox-proportional hazard regression for all variables revealed that the nodal status, distant metastasis, miR-21, miR-141, miR-182, and miR-183 were independent prognostic markers of CRC.In conclusion, altered expressions of miR-21, miR-141, miR-182, and miR-183 in CRC varies at different stages of CRC development and may serve as potential diagnosis molecular biomarkers in Romanian patients with CRC. +other 31764853 hsa-mir-182 Colorectal Neoplasms The univariate and multivariate Cox-proportional hazard regression for all variables revealed that the nodal status, distant metastasis, miR-21, miR-141, miR-182, and miR-183 were independent prognostic markers of CRC.In conclusion, altered expressions of miR-21, miR-141, miR-182, and miR-183 in CRC varies at different stages of CRC development and may serve as potential diagnosis molecular biomarkers in Romanian patients with CRC. +other 31764853 hsa-mir-141 Colorectal Neoplasms The univariate and multivariate Cox-proportional hazard regression for all variables revealed that the nodal status, distant metastasis, miR-21, miR-141, miR-182, and miR-183 were independent prognostic markers of CRC.In conclusion, altered expressions of miR-21, miR-141, miR-182, and miR-183 in CRC varies at different stages of CRC development and may serve as potential diagnosis molecular biomarkers in Romanian patients with CRC. +other 31764830 hsa-mir-21 Acute Coronary Syndrome These studies show that miR-21 is an important factor leading to vulnerable plaque instability in ACS, and it can be a predictor of acute adverse events in coronary heart disease. +other 31764100 hsa-mir-125a Acquired Immunodeficiency Syndrome RESULTS Higher miR-125a-5p and miR5p expression levels were each associated with increased risk of developing MI after adjustment for Framingham Risk Score and HIV-related factors (hazard ratio 2.43, P=0.018; hazard ratio 2.13, P=0.048, respectively). +other 31764100 hsa-mir-139 Acquired Immunodeficiency Syndrome CONCLUSION MiR-125a-5p and miR5p, transcripts known to be differentially expressed in HIV-positive individuals, may serve as unique biomarkers predictive of cardiovascular disease in these patients and may help clarify processes because of HIV infection that contribute to cardiovascular disorders in this population. +other 31764100 hsa-mir-139 Myocardial Infarction CONCLUSION MiR-125a-5p and miR5p, transcripts known to be differentially expressed in HIV-positive individuals, may serve as unique biomarkers predictive of cardiovascular disease in these patients and may help clarify processes because of HIV infection that contribute to cardiovascular disorders in this population. +other 31764100 hsa-mir-125a Myocardial Infarction RESULTS Higher miR-125a-5p and miR5p expression levels were each associated with increased risk of developing MI after adjustment for Framingham Risk Score and HIV-related factors (hazard ratio 2.43, P=0.018; hazard ratio 2.13, P=0.048, respectively). +circulation_biomarker_diagnosis_ns 31763826 hsa-mir-133a Myocardial Infarction In this way, two AMI-related miRNAs, miRNA-499 and miRNA-133a, are successfully detected in real patients' serum with a naked eye-visualized CL change at 10 fM, showing a 5 order of magnitude improvement on the sensitivity of visualizing the same disease markers in clinical circulating blood as compared to the reported strategy. +circulation_biomarker_diagnosis_ns 31763826 hsa-mir-499 Myocardial Infarction In this way, two AMI-related miRNAs, miRNA-499 and miRNA-133a, are successfully detected in real patients' serum with a naked eye-visualized CL change at 10 fM, showing a 5 order of magnitude improvement on the sensitivity of visualizing the same disease markers in clinical circulating blood as compared to the reported strategy. +circulation_biomarker_diagnosis_up 31763742 hsa-mir-885 Diabetic Nephropathies 3p is down-regulated and the levels of pro-inflammatory cytokines are increased in peripheral blood mononuclear cells (PBMCs) from T1D patients compared to healthy controls. +transcription factor target 31763724 hsa-mir-483 Colorectal Neoplasms Thus, miR3p might be a potential target in BRB anthocyanin-mediated prevention of CRC. +exosome 31763681 hsa-mir-1255a Breast Neoplasms In conclusion, the present study preliminarily indicates that exosomal miR5p and miR-1255a may be novel therapeutic targets for BC. +exosome 31763681 hsa-mir-455 Breast Neoplasms In conclusion, the present study preliminarily indicates that exosomal miR5p and miR-1255a may be novel therapeutic targets for BC. +genetics_overexpression_promote 31763673 hsa-mir-27b Colorectal Neoplasms The effect of miR-27b-3p overexpression on cell proliferation in CRC cells was evaluated by cell counting and Edu assays. +transcription factor target 31763669 hsa-mir-146a Heart Failure These results demonstrated that inhibition of miR-146a improved cardiac dysfunction and cardiac remodeling in heart failure rats. +genetics_overexpression_promote 31763513 hsa-mir-22 Carcinoma, Renal Cell Overexpression of miR-22 promoted invasion of primary ccRCC cells in vitro and modulated transcriptional programs implicated in cancer progression including DNA repair, cell proliferation and invasion. +other 31762962 hsa-mir-20b Pulmonary Disease, Chronic Obstructive 3p) in COPD versus smokers or non-smokers in a pairwise comparison. +other 31762962 hsa-mir-22 Pulmonary Disease, Chronic Obstructive 3p) in COPD versus smokers or non-smokers in a pairwise comparison. +other 31762962 hsa-mir-937 Pulmonary Disease, Chronic Obstructive 3p) in COPD versus smokers or non-smokers in a pairwise comparison. +other 31762962 hsa-mir-628 Pulmonary Disease, Chronic Obstructive 3p) in COPD versus smokers or non-smokers in a pairwise comparison. +other 31762962 hsa-mir-335 Pulmonary Disease, Chronic Obstructive 3p) in COPD versus smokers or non-smokers in a pairwise comparison. +other 31762962 hsa-mir-99a Pulmonary Disease, Chronic Obstructive 3p) in COPD versus smokers or non-smokers in a pairwise comparison. +other 31762962 hsa-mir-887 Pulmonary Disease, Chronic Obstructive 3p) in COPD versus smokers or non-smokers in a pairwise comparison. +other 31762962 hsa-mir-320d Pulmonary Disease, Chronic Obstructive 3p) in COPD versus smokers or non-smokers in a pairwise comparison. +genetics_overexpression_promote 31762811 hsa-mir-486 Carcinoma, Non-Small-Cell Lung 5p overexpression suppressed TGF-beta-induced EMT and migration and invasion of NSCLC cells. +genetics_knock down_promote 31762692 hsa-mir-140 salivary gland adenoid cystic carcinoma 5p overexpression in SACC cells. +other 31762266 hsa-mir-16 Enterovirus Infections 5p, potential biomarkers of EV71 infection, can be easily achieved with femtomolar sensitivity and single-base mismatch specificity. +other 31762266 hsa-mir-296 Enterovirus Infections 5p, potential biomarkers of EV71 infection, can be easily achieved with femtomolar sensitivity and single-base mismatch specificity. +other 31762071 hsa-mir-122 Asthenozoospermia Our data indicated that in contrast to the miR-15b, significant increasing of miR-383 and miR-122 occurred in both severe oligoasthenoteratozoospermia (SOAT) and moderate oligoasthenoteratozoospermia (MOAT) compared to normal sperm group (N). +other 31762071 hsa-mir-15b Oligospermia Our data indicated that in contrast to the miR-15b, significant increasing of miR-383 and miR-122 occurred in both severe oligoasthenoteratozoospermia (SOAT) and moderate oligoasthenoteratozoospermia (MOAT) compared to normal sperm group (N). +other 31762071 hsa-mir-122 Azoospermia, Nonobstructive In addition, it was observed that miR-15b and miR-122 increased in patients with nonobstructive azoospermia (NOA) compared with obstructive azoospermia (OA) group. +other 31762071 hsa-mir-383 Alzheimer Disease Our data indicated that in contrast to the miR-15b, significant increasing of miR-383 and miR-122 occurred in both severe oligoasthenoteratozoospermia (SOAT) and moderate oligoasthenoteratozoospermia (MOAT) compared to normal sperm group (N). +other 31762071 hsa-mir-383 Osteoarthritis Our data indicated that in contrast to the miR-15b, significant increasing of miR-383 and miR-122 occurred in both severe oligoasthenoteratozoospermia (SOAT) and moderate oligoasthenoteratozoospermia (MOAT) compared to normal sperm group (N). +other 31762071 hsa-mir-383 Asthenozoospermia Our data indicated that in contrast to the miR-15b, significant increasing of miR-383 and miR-122 occurred in both severe oligoasthenoteratozoospermia (SOAT) and moderate oligoasthenoteratozoospermia (MOAT) compared to normal sperm group (N). +other 31762071 hsa-mir-383 Oligospermia Our data indicated that in contrast to the miR-15b, significant increasing of miR-383 and miR-122 occurred in both severe oligoasthenoteratozoospermia (SOAT) and moderate oligoasthenoteratozoospermia (MOAT) compared to normal sperm group (N). +other 31762071 hsa-mir-122 Noma In addition, it was observed that miR-15b and miR-122 increased in patients with nonobstructive azoospermia (NOA) compared with obstructive azoospermia (OA) group. +other 31762071 hsa-mir-383 Osteochondrodysplasias Our data indicated that in contrast to the miR-15b, significant increasing of miR-383 and miR-122 occurred in both severe oligoasthenoteratozoospermia (SOAT) and moderate oligoasthenoteratozoospermia (MOAT) compared to normal sperm group (N). +other 31762071 hsa-mir-15b Aspermia In addition, it was observed that miR-15b and miR-122 increased in patients with nonobstructive azoospermia (NOA) compared with obstructive azoospermia (OA) group. +other 31762071 hsa-mir-122 Oligospermia Our data indicated that in contrast to the miR-15b, significant increasing of miR-383 and miR-122 occurred in both severe oligoasthenoteratozoospermia (SOAT) and moderate oligoasthenoteratozoospermia (MOAT) compared to normal sperm group (N). +other 31762071 hsa-mir-122 Alzheimer Disease Our data indicated that in contrast to the miR-15b, significant increasing of miR-383 and miR-122 occurred in both severe oligoasthenoteratozoospermia (SOAT) and moderate oligoasthenoteratozoospermia (MOAT) compared to normal sperm group (N). +other 31762071 hsa-mir-15b Alzheimer Disease Our data indicated that in contrast to the miR-15b, significant increasing of miR-383 and miR-122 occurred in both severe oligoasthenoteratozoospermia (SOAT) and moderate oligoasthenoteratozoospermia (MOAT) compared to normal sperm group (N). +other 31762071 hsa-mir-15b Azoospermia, Nonobstructive In addition, it was observed that miR-15b and miR-122 increased in patients with nonobstructive azoospermia (NOA) compared with obstructive azoospermia (OA) group. +other 31762071 hsa-mir-15b Noma In addition, it was observed that miR-15b and miR-122 increased in patients with nonobstructive azoospermia (NOA) compared with obstructive azoospermia (OA) group. +other 31762071 hsa-mir-122 Osteoarthritis Our data indicated that in contrast to the miR-15b, significant increasing of miR-383 and miR-122 occurred in both severe oligoasthenoteratozoospermia (SOAT) and moderate oligoasthenoteratozoospermia (MOAT) compared to normal sperm group (N). In addition, it was observed that miR-15b and miR-122 increased in patients with nonobstructive azoospermia (NOA) compared with obstructive azoospermia (OA) group. +other 31762071 hsa-mir-122 Osteochondrodysplasias Our data indicated that in contrast to the miR-15b, significant increasing of miR-383 and miR-122 occurred in both severe oligoasthenoteratozoospermia (SOAT) and moderate oligoasthenoteratozoospermia (MOAT) compared to normal sperm group (N). +other 31762071 hsa-mir-122 Aspermia In addition, it was observed that miR-15b and miR-122 increased in patients with nonobstructive azoospermia (NOA) compared with obstructive azoospermia (OA) group. +other 31762071 hsa-mir-15b Osteochondrodysplasias Our data indicated that in contrast to the miR-15b, significant increasing of miR-383 and miR-122 occurred in both severe oligoasthenoteratozoospermia (SOAT) and moderate oligoasthenoteratozoospermia (MOAT) compared to normal sperm group (N). +other 31762071 hsa-mir-15b Osteoarthritis Our data indicated that in contrast to the miR-15b, significant increasing of miR-383 and miR-122 occurred in both severe oligoasthenoteratozoospermia (SOAT) and moderate oligoasthenoteratozoospermia (MOAT) compared to normal sperm group (N). In addition, it was observed that miR-15b and miR-122 increased in patients with nonobstructive azoospermia (NOA) compared with obstructive azoospermia (OA) group. +other 31762071 hsa-mir-15b Asthenozoospermia Our data indicated that in contrast to the miR-15b, significant increasing of miR-383 and miR-122 occurred in both severe oligoasthenoteratozoospermia (SOAT) and moderate oligoasthenoteratozoospermia (MOAT) compared to normal sperm group (N). +lncRNA target 31761787 hsa-mir-93 Dermatitis Our results proved that Meg3 was involved in UVB-induced skin inflammation and that the ceRNA networks, which includes miR5p and Ereg, could prove to be a potential therapeutic target for UVB-induced skin damage. +lncRNA target 31761787 hsa-mir-93 Sunburn Our results proved that Meg3 was involved in UVB-induced skin inflammation and that the ceRNA networks, which includes miR5p and Ereg, could prove to be a potential therapeutic target for UVB-induced skin damage. +other 31760709 hsa-mir-214 Inflammation The infusion of miRsecretome also led to lesser local and systemic inflammation, higher expression of an antioxidant enzyme (superoxide dismutase), and higher liver proliferative and synthetic function. +other 31760709 hsa-mir-214 Fibrosis secretome is thus expected to be one of the prominent ways of overcoming liver fibrosis, if further studies consistently validate its safety and efficiency. +other 31760527 hsa-mir-34 Carcinoma, Non-Small-Cell Lung RESULTS: Analysis of publicly available datasets from patients with NSCLC did not reveal significant genomic alterations in RBM38, SIRT1, HIF1A, MIR34A, MIR34B, and MIR34C, but expectedly revealed alterations in TP53. CONCLUSIONS: Cumulatively, our results reveal a novel mechanism of RBM38-mediated regulation of the HIF1A/miR-34a/SIRT1/p53 axis under hypoxia in NSCLC cells. +other 31760527 hsa-mir-34a Carcinoma, Non-Small-Cell Lung RESULTS: Analysis of publicly available datasets from patients with NSCLC did not reveal significant genomic alterations in RBM38, SIRT1, HIF1A, MIR34A, MIR34B, and MIR34C, but expectedly revealed alterations in TP53. CONCLUSIONS: Cumulatively, our results reveal a novel mechanism of RBM38-mediated regulation of the HIF1A/miR-34a/SIRT1/p53 axis under hypoxia in NSCLC cells. +genetics_overexpression_promote 31760502 hsa-mir-140 Osteoarthritis CONCLUSIONS: In conclusion, these results indicate therapeutic superiority of hUC-MSCs overexpressing miR +lncRNA target 31760375 hsa-mir-29a Pituitary Diseases These data indicate that miR-29a-3p plays a protective role in TNFalpha-induced endothelial dysfunction, suggesting that miR-29a-3p is a novel target for the prevention and treatment of atherosclerosis. +other 31760375 hsa-mir-29a Cardiovascular Diseases miR-29a-3p has been shown to be associated with cardiovascular diseases; however, the effect of miR-29a-3p on endothelial dysfunction is unclear. +lncRNA target 31760170 hsa-mir-20a Colorectal Neoplasms Moreover, HAND2-AS1 suppressed cell progression and 5-FU resistance by upregulating PDCD4 via sponging miR-20a in 5-FU-resistant CRC cells. +genetics_overexpression_promote 31760045 hsa-mir-147b Thyroid Neoplasms miR-147b inhibition or SOX15 overexpression retarded the tumor growth of thyroid carcinoma cells in vivo. +genetics_overexpression_promote 31759996 hsa-mir-21 Diabetic Retinopathy To conclude, our results indicated that miR-21 overexpression could potentially stimulate RVEC viability and angiogenesis in rats with DR through activation of the PI3K/Akt/VEGF signaling pathway via repressing PTEN expression, highlighting the potential of miR-21 as a target for DR treatment. +other 31759982 hsa-mir-200c Prostatic Neoplasms This ability of hsa-miR-200c to reclaim epithelial traits leads to the anticipation that molecular reprogramming of Zeb1-Slug/vimentin axis may relieve aggressiveness of prostate cancer. +lncRNA target 31759899 hsa-mir-592 Alzheimer Disease The mechanism of miR-592, KIAA0319 and the Keap1/Nrf2/ARE signaling pathway in AD was examined after transducing miR-592 mimic, miR-592 inhibitor and siRNA-KIAA0319 into ASTs to query cell viability, OS injury and reactive oxygen species (ROS). +genetics_GWAS 31759375 hsa-mir-196a-2 Carcinoma, Hepatocellular For miR-196a2 (rs11614913) C>T polymorphisms, no significant association was found with HCC risk. +genetics_GWAS 31759375 hsa-mir-196a-2 Hepatitis C For miR-196a2 (rs11614913) C>T polymorphisms, no significant association was found with HCC risk. +transcription factor target 31759360 hsa-mir-125a Lung Neoplasms Different studies indicated that miRNA-125a-5p is down-regulated in human lung cancer cells and may function as a tumor suppressor by targeting EGFR. +lncRNA target 31759247 hsa-mir-27b Plaque, Atherosclerotic CSE was identified as a direct target of the KLF2-regulated microRNA, miR-27b and high expression of CSE in native human plaque-derived endothelial cells, was also inversely correlated with KLF2 and miR-27b levels. +exosome 31759057 hsa-mir-122 Osteochondrodysplasias Cholesterol-induced lysosomal dysfunction increases exosome release from hepatocytes, resulting in M1 polarization and macrophage-induced inflammation in a miR +exosome 31759057 hsa-mir-122 Inflammation Cholesterol-induced lysosomal dysfunction increases exosome release from hepatocytes, resulting in M1 polarization and macrophage-induced inflammation in a miR +other 31758923 hsa-mir-155 Inflammation Since miR-155 is well known for its multifunctional roles in immunity, inflammation, and cancer, our data suggest that this and other miRNAs contribute to coordinated downregulation of drug metabolizing enzymes and transporters in inflammatory conditions. +other 31758917 hsa-mir-143 Diabetic Nephropathies TAC administration induced cardiac fibrosis and heart weight increase, which was associated with the induced expressions of TGF-beta1, miR3p, p-Smad2, and collagens. +genetics_knock down_promote 31758671 hsa-mir-486 Carcinoma, Hepatocellular 5p had the potential to eliminate the tumor-suppressive effects of circ-TCF4.85 knockdown in HCC. +lncRNA target 31758655 hsa-mir-1184 Urinary Bladder Neoplasms Mechanistically, we demonstrated that circVANGL1 upregulated the expression of miR-1184 target gene insulin-like growth factor-binding protein 2 (IGFBP2) by sponging miR-1184, which promoted the aggressive biological behaviors of BC. +genetics_knock down_promote 31758653 hsa-mir-423 Adenocarcinoma of Lung Rescue experiments revealed that MYBL2 knockdown could counteract miR +circRNA target 31758574 hsa-mir-382 Osteosarcoma This study demonstrated that circ_0001658 promotes the proliferation and metastasis of OS cells via modulating miR +other 31758402 hsa-mir-34a Stroke Moreover, expression of mature miR-34a-5p and miR-34a-3p in ischemic brain tissue was positively related to infarct size and negatively related to sirtuin 1 (Sirt1) mRNA transcription. +other 31758402 hsa-mir-34a Brain Ischemia Moreover, expression of mature miR-34a-5p and miR-34a-3p in ischemic brain tissue was positively related to infarct size and negatively related to sirtuin 1 (Sirt1) mRNA transcription. +genetics_overexpression_promote 31758392 hsa-mir-663b Colorectal Neoplasms MiR-663b was significantly overexpressed in colorectal tumors and cell lines. +other 31758243 hsa-mir-139 Carcinoma, Hepatocellular CONCLUSION: FOXD2-AS1/miR5p/BLVRA or CYTH2 axis might be the underlying molecular mechanism that dissects HCC development caused by cirrhosis. +circulation_biomarker_diagnosis_ns 31757654 hsa-mir-122 Heart Failure, Systolic CONCLUSION: Circulating miR-122 as a biomarker is predicting all-cause and cardiovascular mortality and improved risk stratification of HFrEF patients. Thus, miR-122 might be a new biomarker for risk assessment in HFrEF. +other 31757017 hsa-mir-29a Colorectal Neoplasms 5p) were confirmed to be significantly higher in the CRC vs. healthy group (P < 0.05). +other 31757017 hsa-mir-186 Colorectal Neoplasms 5p) were confirmed to be significantly higher in the CRC vs. healthy group (P < 0.05). +lncRNA target 31756931 hsa-mir-155 Carcinoma, Renal Cell 5p targeted genes of PPP (the pentose phosphate pathway) (G6PD and TKT), the TCA (tricarboxylic acid cycle) cycle (SUCLG2), and arginine metabolism (GATM), respectively. +lncRNA target 31756546 hsa-mir-21 Colorectal Neoplasms METHODS: Here we report an integrative meta-analysis and bioinformatics methodology that showed microRNA-21 and its associated target mRNA to be the most significant predictive biomarkers for colorectal adenoma and adenocarcinoma. Our three steps bioinformatics approach identified ABCB1, HPGD, BCL2, TIAM1, TLR3, and PDCD4 as common targets for mir-21 in both of adenoma as well as adenocarcinoma suggesting they are biomarkers for early CRC. +other 31756185 hsa-mir-181 Prostatic Neoplasms MiRNA-microarray analysis further identified miR-130a, miR-181, miR-328, miR146 and miR-200 as a panel of novel miRNAs associated with drug resistance drug-efflux and epithelial-to-mesenchymal transition in prostate cancer. +other 31756185 hsa-mir-200 Prostatic Neoplasms MiRNA-microarray analysis further identified miR-130a, miR-181, miR-328, miR146 and miR-200 as a panel of novel miRNAs associated with drug resistance drug-efflux and epithelial-to-mesenchymal transition in prostate cancer. +other 31756185 hsa-mir-130a Prostatic Neoplasms MiRNA-microarray analysis further identified miR-130a, miR-181, miR-328, miR146 and miR-200 as a panel of novel miRNAs associated with drug resistance drug-efflux and epithelial-to-mesenchymal transition in prostate cancer. +other 31756185 hsa-mir-28 Prostatic Neoplasms MiRNA-microarray analysis further identified miR-130a, miR-181, miR-328, miR146 and miR-200 as a panel of novel miRNAs associated with drug resistance drug-efflux and epithelial-to-mesenchymal transition in prostate cancer. +other 31756170 hsa-mir-143 Urinary Bladder Neoplasms Our study demonstrates that circ_0006332 promotes the growth and progression of bladder cancer by modulating MYBL2 expression by acting as a sponge for miR-143. +other 31756048 hsa-mir-148a Endometritis Collectively, pharmacologic stabilization of miR-148a represents a novel therapy for endometritis and other inflammation-related diseases. +other 31755891 hsa-mir-155 Alzheimer Disease Based on this network, we preliminarily identified new potential AD biomarkers including hsa-miR5p, CERS6-AS1, and CTB-89H12.4. +transcription factor target 31755739 hsa-mir-382 Colorectal Neoplasms Conclusion: Polydatin inhibits CRC cell proliferation and promotes apoptosis by regulating miR-382/PD-L1 axis. +lncRNA target 31755734 hsa-mir-1205 Colorectal Neoplasms Through the gain-of-function experiments, they found that ZEB2-AS1 accelerates EMT in CRC cells via modulating the expression of miR-1205 and CRKL. +lncRNA target 31755246 hsa-mir-214 Cataract Mechanistically, PVT1 acted as the 'miRNA sponge' to target miR3p/MMP2 axis. +other 31755219 hsa-mir-22 Myocardial Infarction 3p/KDM3A pathway in MI. +other 31755219 hsa-mir-22 Cardiomyopathies 3p/KDM3A pathway in MI. +lncRNA target 31755218 hsa-mir-101 Breast Neoplasms 5p, the passenger strand of pre-miR-101, and investigated its tumor-suppressive roles and oncogenic targets in BrCa cells. +lncRNA target 31755091 hsa-mir-185 Squamous Cell Carcinoma of Head and Neck KCNQ1OT1 silencing suppressed OSCC cell malignancy and downregulated miR +other 31754458 hsa-let-7b Lung Diseases In addition, mpDisNet identifies network-based comorbidities for pulmonary diseases driven by underlying miRNA-mediated pathobiological pathways (i.e., hsa-let-7a- or hsa-let-7b-mediated airway epithelial apoptosis and pro-inflammatory cytokine pathways) as derived from the human interactome network analysis. +circulation_biomarker_diagnosis_up 31754391 hsa-mir-205 Ovarian Neoplasms Importantly, miR-205 was markedly enriched in the serum of OC patients, and a high level of miR-205 in circulating exosomes was associated with OC metastasis. +other 31754343 hsa-mir-638 Breast Neoplasms Furthermore, CREB1 can also directly bind to the promoter of VASP, and activate VASP expression, forming a CREB/Lin28/miR-638/VASP interactive network, which plays an important role in promoting cell proliferation and migration in breast cancer. Our study explained the mechanism of CREB1/Lin28/miR-638/VASP network promoting the development of breast cancer, which further elucidated the mechanism of VASP as a key oncogene, and also provided a theoretical basis for expanding new approaches to tumor biotherapy. +other 31754335 hsa-mir-199a Acute Lung Injury Here, we discovered that miR-199a-3p was significantly downregulated in ALI lung tissues using a microarray analysis. +transcription factor target 31754334 hsa-mir-93 Neointima MiR-93 inhibition suppressed neointimal formation after carotid artery injury. +transcription factor target 31754334 hsa-mir-93 Graft Occlusion, Vascular MiR-93 may be a new target for treating in-stent restenosis. +transcription factor target 31754329 hsa-mir-124 Diabetes Mellitus These results suggest that EGF may induce the activation of ETS2 to inhibit miR-124a expression to maintain proper beta cell functions and that ETS2, as a novel regulator of insulin production, is a potential therapeutic target for diabetes mellitus treatment. +transcription factor target 31754329 hsa-mir-124a Diabetes Mellitus These results suggest that EGF may induce the activation of ETS2 to inhibit miR-124a expression to maintain proper beta cell functions and that ETS2, as a novel regulator of insulin production, is a potential therapeutic target for diabetes mellitus treatment. +lncRNA target 31754327 hsa-mir-1 Ataxia Neuropathy Spectrum Conclusion: miR-1 is involved in the regulation of neural crest cell development, and that it acts, at least partially, by targeting sec63 expression. +circRNA target 31754311 hsa-mir-1265 Osteosarcoma Rescue experiments indicated that circMMP9 contributes to OS development through the miR-1265/CHI3L1 pathway. +lncRNA target 31754305 hsa-mir-497 Squamous Cell Carcinoma of Head and Neck CONCLUSION: The observations in this study identify CDKN2B-AS1 an oncogenic role in the tumorigenesis of LSCC by regulating miR-497/CDK6 axis and indicate that it may serve as a potential target for LSCC treatment. +transcription factor target 31754297 hsa-mir-26a Melanoma CONCLUSION: Taken together, we showed that miR-26a is involved in the regulation of dabrafenib efficacy via a HMGB1-dependent autophagy pathway in melanoma cells. +circulation_biomarker_diagnosis_ns 31754293 hsa-mir-23 Carcinoma, Hepatocellular Two miRNAs (miR-34a, miR-221) were significantly up-regulated and five miRNAs (miR-16, miR-23-3p, miR-122-5p, miR-198, miR-199a-3p) were significantly down-regulated in HCC compared to LC patients. +circulation_biomarker_diagnosis_ns 31754293 hsa-mir-221 Carcinoma, Hepatocellular Two miRNAs (miR-34a, miR-221) were significantly up-regulated and five miRNAs (miR-16, miR-23-3p, miR-122-5p, miR-198, miR-199a-3p) were significantly down-regulated in HCC compared to LC patients. +circulation_biomarker_diagnosis_ns 31754293 hsa-mir-16 Carcinoma, Hepatocellular Two miRNAs (miR-34a, miR-221) were significantly up-regulated and five miRNAs (miR-16, miR-23-3p, miR-122-5p, miR-198, miR-199a-3p) were significantly down-regulated in HCC compared to LC patients. +circulation_biomarker_diagnosis_ns 31754293 hsa-mir-198 Carcinoma, Hepatocellular Two miRNAs (miR-34a, miR-221) were significantly up-regulated and five miRNAs (miR-16, miR-23-3p, miR-122-5p, miR-198, miR-199a-3p) were significantly down-regulated in HCC compared to LC patients. +circulation_biomarker_diagnosis_ns 31754293 hsa-mir-34a Carcinoma, Hepatocellular Two miRNAs (miR-34a, miR-221) were significantly up-regulated and five miRNAs (miR-16, miR-23-3p, miR-122-5p, miR-198, miR-199a-3p) were significantly down-regulated in HCC compared to LC patients. +circulation_biomarker_diagnosis_ns 31754293 hsa-mir-199a Carcinoma, Hepatocellular Two miRNAs (miR-34a, miR-221) were significantly up-regulated and five miRNAs (miR-16, miR-23-3p, miR-122-5p, miR-198, miR-199a-3p) were significantly down-regulated in HCC compared to LC patients. +circulation_biomarker_diagnosis_ns 31754293 hsa-mir-122 Carcinoma, Hepatocellular Two miRNAs (miR-34a, miR-221) were significantly up-regulated and five miRNAs (miR-16, miR-23-3p, miR-122-5p, miR-198, miR-199a-3p) were significantly down-regulated in HCC compared to LC patients. +circulation_biomarker_diagnosis_ns 31754291 hsa-mir-490 Esophageal Squamous Cell Carcinoma Colony formation and Transwell invasion assays showed that knockdown of lncRNAXLOC_001659 or overexpression of miR-490-5p significantly inhibited ESCC cell growth and invasion. +other 31754211 hsa-mir-128 Carcinoma, Hepatocellular These findings highlight a regulatory circuit between LINC01149 and MICA, mediating by miR-128-3p, and the important role of upregulated MICA in conferring susceptibility to persistent HBV infection and HCC. +other 31753063 hsa-mir-29c Medulloblastoma Our study demonstrates that CRNDE acts as a critical mediator of proliferation, apoptosis, migration, invasion, and resistance to chemotherapeutics via binding to and negatively regulating miR-29c-3p in medulloblastoma cells. +other 31752906 hsa-mir-502 gallbladder carcinoma Our study demonstrates that lncRNA-HGBC promotes GBC metastasis via activation of the miR-502-3p-SET-AKT cascade +other 31752524 hsa-mir-21 Liver Cirrhosis regulated TGF-beta1/Smad signaling pathway in LX2 cells and CCl(4)-induced liver fibrosis rats, which may provide a novel therapeutic strategy for liver fibrosis. +tissue_expression_down 31752117 hsa-mir-29b Prostatic Neoplasms We previously demonstrated that miRNA-29b-3p (miR-29b) was downregulated in prostate cancer and that the overexpression of miR-29b limited prostate cancer metastasis. +other 31752063 hsa-mir-139 Osteoporosis 5p was increased, compared with normal group. +tissue_expression_down 31752018 hsa-mir-487b Sjogren's Syndrome The expression levels of miR-16-5p, miR-34a-5p, miR-142-3p, and miR-223-3p were significantly upregulated in patients with SS when compared with those in the control group (P < 0.05). The expression of 10 miRNAs (miR-30b-5p, miR-30c-5p, miR-30d-5p, miR-92a-3p, miR-134-5p, miR-137, miR-302d-5p, miR-365b-3p, miR-374c-5p, miR-487b-3p) was significantly downregulated in the SS patients (P < 0.05). +tissue_expression_down 31752018 hsa-mir-374c Sjogren's Syndrome The expression levels of miR-16-5p, miR-34a-5p, miR-142-3p, and miR-223-3p were significantly upregulated in patients with SS when compared with those in the control group (P < 0.05). The expression of 10 miRNAs (miR-30b-5p, miR-30c-5p, miR-30d-5p, miR-92a-3p, miR-134-5p, miR-137, miR-302d-5p, miR-365b-3p, miR-374c-5p, miR-487b-3p) was significantly downregulated in the SS patients (P < 0.05). +tissue_expression_up 31752018 hsa-mir-34a Sjogren's Syndrome The expression levels of miR-16-5p, miR-34a-5p, miR-142-3p, and miR-223-3p were significantly upregulated in patients with SS when compared with those in the control group (P < 0.05). The expression of 10 miRNAs (miR-30b-5p, miR-30c-5p, miR-30d-5p, miR-92a-3p, miR-134-5p, miR-137, miR-302d-5p, miR-365b-3p, miR-374c-5p, miR-487b-3p) was significantly downregulated in the SS patients (P < 0.05). +tissue_expression_down 31752018 hsa-mir-92a Sjogren's Syndrome The expression levels of miR-16-5p, miR-34a-5p, miR-142-3p, and miR-223-3p were significantly upregulated in patients with SS when compared with those in the control group (P < 0.05). The expression of 10 miRNAs (miR-30b-5p, miR-30c-5p, miR-30d-5p, miR-92a-3p, miR-134-5p, miR-137, miR-302d-5p, miR-365b-3p, miR-374c-5p, miR-487b-3p) was significantly downregulated in the SS patients (P < 0.05). +tissue_expression_up 31752018 hsa-mir-16 Sjogren's Syndrome The expression levels of miR-16-5p, miR-34a-5p, miR-142-3p, and miR-223-3p were significantly upregulated in patients with SS when compared with those in the control group (P < 0.05). The expression of 10 miRNAs (miR-30b-5p, miR-30c-5p, miR-30d-5p, miR-92a-3p, miR-134-5p, miR-137, miR-302d-5p, miR-365b-3p, miR-374c-5p, miR-487b-3p) was significantly downregulated in the SS patients (P < 0.05). +tissue_expression_down 31752018 hsa-mir-134 Sjogren's Syndrome The expression levels of miR-16-5p, miR-34a-5p, miR-142-3p, and miR-223-3p were significantly upregulated in patients with SS when compared with those in the control group (P < 0.05). The expression of 10 miRNAs (miR-30b-5p, miR-30c-5p, miR-30d-5p, miR-92a-3p, miR-134-5p, miR-137, miR-302d-5p, miR-365b-3p, miR-374c-5p, miR-487b-3p) was significantly downregulated in the SS patients (P < 0.05). +tissue_expression_down 31752018 hsa-mir-137 Sjogren's Syndrome The expression levels of miR-16-5p, miR-34a-5p, miR-142-3p, and miR-223-3p were significantly upregulated in patients with SS when compared with those in the control group (P < 0.05). The expression of 10 miRNAs (miR-30b-5p, miR-30c-5p, miR-30d-5p, miR-92a-3p, miR-134-5p, miR-137, miR-302d-5p, miR-365b-3p, miR-374c-5p, miR-487b-3p) was significantly downregulated in the SS patients (P < 0.05). +tissue_expression_down 31752018 hsa-mir-365b Sjogren's Syndrome The expression levels of miR-16-5p, miR-34a-5p, miR-142-3p, and miR-223-3p were significantly upregulated in patients with SS when compared with those in the control group (P < 0.05). The expression of 10 miRNAs (miR-30b-5p, miR-30c-5p, miR-30d-5p, miR-92a-3p, miR-134-5p, miR-137, miR-302d-5p, miR-365b-3p, miR-374c-5p, miR-487b-3p) was significantly downregulated in the SS patients (P < 0.05). +tissue_expression_up 31752018 hsa-mir-142 Sjogren's Syndrome The expression levels of miR-16-5p, miR-34a-5p, miR-142-3p, and miR-223-3p were significantly upregulated in patients with SS when compared with those in the control group (P < 0.05). The expression of 10 miRNAs (miR-30b-5p, miR-30c-5p, miR-30d-5p, miR-92a-3p, miR-134-5p, miR-137, miR-302d-5p, miR-365b-3p, miR-374c-5p, miR-487b-3p) was significantly downregulated in the SS patients (P < 0.05). +tissue_expression_up 31752018 hsa-mir-223 Sjogren's Syndrome The expression levels of miR-16-5p, miR-34a-5p, miR-142-3p, and miR-223-3p were significantly upregulated in patients with SS when compared with those in the control group (P < 0.05). The expression of 10 miRNAs (miR-30b-5p, miR-30c-5p, miR-30d-5p, miR-92a-3p, miR-134-5p, miR-137, miR-302d-5p, miR-365b-3p, miR-374c-5p, miR-487b-3p) was significantly downregulated in the SS patients (P < 0.05). +other 31752013 hsa-mir-155 Cardiovascular Diseases we also explored the function of miR-155 as a regulator of cardiovascular diseases. +other 31751869 hsa-mir-342 Glioblastoma In addition, flow cytometry analysis indicated that miR-342 overexpression induced apoptosis in glioblastoma cells. +genetics_knock down_suppress 31751592 hsa-mir-26b Reperfusion Injury, Cerebral Ischemia Conversely, Smad1 overexpression reversed the inhibitory effect of miR-26b-5p on CI / R-induced apoptosis and inflammatory responses in rats. +other 31751571 hsa-mir-96 Multiple System Atrophy FTY720-Mitoxy also increased levels of brain GDNF and reduced brain miR-96-5p, a miRNA that acts to decrease GDNF expression. +genetics_GWAS 31751306 hsa-mir-155 Diabetic Retinopathy These findings support that the rs767649 polymorphism in the pre-MIR155 gene is associated with DR in T2DM and that the miR-155 plasma levels might be associated with T2DM. +other 31750910 hsa-mir-29a Colorectal Neoplasms the miR-29a-5p/STAT3 positive feedback loop may amplify the effects of inflammation, lead to decreased levels of TET and 5hmC, and eventually lead to the development of CAC. +other 31750728 hsa-mir-137 Glioma NCK1-AS1 could increase drug resistance of glioma cells to TMZ by modulating miR-137/TRIM24 pathway. +other 31750632 hsa-mir-522 Uterine Cervical Neoplasms The preliminary report revealed that the SNP rs4846048 of MTHFR enhanced the risk of CC through association with miR-522 +circulation_biomarker_diagnosis_ns 31750616 hsa-mir-139 Drug Resistant Epilepsy We identified that miR-139-5p was decreased and multidrug resistance-associated protein 1 (MRP1) was remarkably upregulated in the serum samples from children with refractory epilepsy and the brain tissues from rat models of refractory epilepsy. +tissue_expression_up 31750597 hsa-mir-143 Colorectal Neoplasms In isolated CRC gland cells, the expression levels of six miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-31-5p, hsa-miRNA-27b-3p and hsa-miRNA-27a-3p) were upregulated, whereas those of seven miRNAs (hsa-miRNA-21-5p, hsa-miRNA-195-5p, hsa-miRNA-19a-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p and hsa-let-7a-5p) were downregulated, compared with the corresponding isolated normal gland specimens. In the isolated CRC stromal cells, the expression levels of three miRNAs (hsa-miRNA-21-5p, hsa-miRNA-31-5p and hsa-miRNA-27b-3p) were upregulated and those of 10 miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-195-5p, hsa-miRNA-19a-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p, hsa-let-7a-5p and hsa-miRNA-27a-3p) were downregulated compared with the corresponding normal fibroblasts. Finally, in the intact tumor mucosa samples, the expression levels of three miRNAs (hsa-miRNA-31-5p, hsa-miRNA-19a-3p and hsa-let-7a-5p) were upregulated, and those of 10 miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-21-5p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-195-5p, hsa-miRNA-27b-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p and hsa-miRNA-27a-3p) were downregulated, compared with normal mucosa specimens. +tissue_expression_down 31750597 hsa-mir-186 Colorectal Neoplasms In isolated CRC gland cells, the expression levels of six miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-31-5p, hsa-miRNA-27b-3p and hsa-miRNA-27a-3p) were upregulated, whereas those of seven miRNAs (hsa-miRNA-21-5p, hsa-miRNA-195-5p, hsa-miRNA-19a-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p and hsa-let-7a-5p) were downregulated, compared with the corresponding isolated normal gland specimens. In the isolated CRC stromal cells, the expression levels of three miRNAs (hsa-miRNA-21-5p, hsa-miRNA-31-5p and hsa-miRNA-27b-3p) were upregulated and those of 10 miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-195-5p, hsa-miRNA-19a-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p, hsa-let-7a-5p and hsa-miRNA-27a-3p) were downregulated compared with the corresponding normal fibroblasts. Finally, in the intact tumor mucosa samples, the expression levels of three miRNAs (hsa-miRNA-31-5p, hsa-miRNA-19a-3p and hsa-let-7a-5p) were upregulated, and those of 10 miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-21-5p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-195-5p, hsa-miRNA-27b-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p and hsa-miRNA-27a-3p) were downregulated, compared with normal mucosa specimens. +tissue_expression_up 31750597 hsa-mir-206 Colorectal Neoplasms In isolated CRC gland cells, the expression levels of six miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-31-5p, hsa-miRNA-27b-3p and hsa-miRNA-27a-3p) were upregulated, whereas those of seven miRNAs (hsa-miRNA-21-5p, hsa-miRNA-195-5p, hsa-miRNA-19a-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p and hsa-let-7a-5p) were downregulated, compared with the corresponding isolated normal gland specimens. In the isolated CRC stromal cells, the expression levels of three miRNAs (hsa-miRNA-21-5p, hsa-miRNA-31-5p and hsa-miRNA-27b-3p) were upregulated and those of 10 miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-195-5p, hsa-miRNA-19a-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p, hsa-let-7a-5p and hsa-miRNA-27a-3p) were downregulated compared with the corresponding normal fibroblasts. Finally, in the intact tumor mucosa samples, the expression levels of three miRNAs (hsa-miRNA-31-5p, hsa-miRNA-19a-3p and hsa-let-7a-5p) were upregulated, and those of 10 miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-21-5p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-195-5p, hsa-miRNA-27b-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p and hsa-miRNA-27a-3p) were downregulated, compared with normal mucosa specimens. +tissue_expression_down 31750597 hsa-mir-21 Colorectal Neoplasms In isolated CRC gland cells, the expression levels of six miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-31-5p, hsa-miRNA-27b-3p and hsa-miRNA-27a-3p) were upregulated, whereas those of seven miRNAs (hsa-miRNA-21-5p, hsa-miRNA-195-5p, hsa-miRNA-19a-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p and hsa-let-7a-5p) were downregulated, compared with the corresponding isolated normal gland specimens. In the isolated CRC stromal cells, the expression levels of three miRNAs (hsa-miRNA-21-5p, hsa-miRNA-31-5p and hsa-miRNA-27b-3p) were upregulated and those of 10 miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-195-5p, hsa-miRNA-19a-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p, hsa-let-7a-5p and hsa-miRNA-27a-3p) were downregulated compared with the corresponding normal fibroblasts. Finally, in the intact tumor mucosa samples, the expression levels of three miRNAs (hsa-miRNA-31-5p, hsa-miRNA-19a-3p and hsa-let-7a-5p) were upregulated, and those of 10 miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-21-5p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-195-5p, hsa-miRNA-27b-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p and hsa-miRNA-27a-3p) were downregulated, compared with normal mucosa specimens. +tissue_expression_down 31750597 hsa-mir-195 Colorectal Neoplasms In isolated CRC gland cells, the expression levels of six miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-31-5p, hsa-miRNA-27b-3p and hsa-miRNA-27a-3p) were upregulated, whereas those of seven miRNAs (hsa-miRNA-21-5p, hsa-miRNA-195-5p, hsa-miRNA-19a-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p and hsa-let-7a-5p) were downregulated, compared with the corresponding isolated normal gland specimens. In the isolated CRC stromal cells, the expression levels of three miRNAs (hsa-miRNA-21-5p, hsa-miRNA-31-5p and hsa-miRNA-27b-3p) were upregulated and those of 10 miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-195-5p, hsa-miRNA-19a-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p, hsa-let-7a-5p and hsa-miRNA-27a-3p) were downregulated compared with the corresponding normal fibroblasts. Finally, in the intact tumor mucosa samples, the expression levels of three miRNAs (hsa-miRNA-31-5p, hsa-miRNA-19a-3p and hsa-let-7a-5p) were upregulated, and those of 10 miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-21-5p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-195-5p, hsa-miRNA-27b-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p and hsa-miRNA-27a-3p) were downregulated, compared with normal mucosa specimens. +tissue_expression_up 31750597 hsa-mir-27b Colorectal Neoplasms In isolated CRC gland cells, the expression levels of six miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-31-5p, hsa-miRNA-27b-3p and hsa-miRNA-27a-3p) were upregulated, whereas those of seven miRNAs (hsa-miRNA-21-5p, hsa-miRNA-195-5p, hsa-miRNA-19a-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p and hsa-let-7a-5p) were downregulated, compared with the corresponding isolated normal gland specimens. In the isolated CRC stromal cells, the expression levels of three miRNAs (hsa-miRNA-21-5p, hsa-miRNA-31-5p and hsa-miRNA-27b-3p) were upregulated and those of 10 miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-195-5p, hsa-miRNA-19a-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p, hsa-let-7a-5p and hsa-miRNA-27a-3p) were downregulated compared with the corresponding normal fibroblasts. Finally, in the intact tumor mucosa samples, the expression levels of three miRNAs (hsa-miRNA-31-5p, hsa-miRNA-19a-3p and hsa-let-7a-5p) were upregulated, and those of 10 miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-21-5p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-195-5p, hsa-miRNA-27b-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p and hsa-miRNA-27a-3p) were downregulated, compared with normal mucosa specimens. +tissue_expression_down 31750597 hsa-mir-191 Colorectal Neoplasms In isolated CRC gland cells, the expression levels of six miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-31-5p, hsa-miRNA-27b-3p and hsa-miRNA-27a-3p) were upregulated, whereas those of seven miRNAs (hsa-miRNA-21-5p, hsa-miRNA-195-5p, hsa-miRNA-19a-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p and hsa-let-7a-5p) were downregulated, compared with the corresponding isolated normal gland specimens. In the isolated CRC stromal cells, the expression levels of three miRNAs (hsa-miRNA-21-5p, hsa-miRNA-31-5p and hsa-miRNA-27b-3p) were upregulated and those of 10 miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-195-5p, hsa-miRNA-19a-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p, hsa-let-7a-5p and hsa-miRNA-27a-3p) were downregulated compared with the corresponding normal fibroblasts. Finally, in the intact tumor mucosa samples, the expression levels of three miRNAs (hsa-miRNA-31-5p, hsa-miRNA-19a-3p and hsa-let-7a-5p) were upregulated, and those of 10 miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-21-5p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-195-5p, hsa-miRNA-27b-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p and hsa-miRNA-27a-3p) were downregulated, compared with normal mucosa specimens. +tissue_expression_up 31750597 hsa-mir-130a Colorectal Neoplasms In isolated CRC gland cells, the expression levels of six miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-31-5p, hsa-miRNA-27b-3p and hsa-miRNA-27a-3p) were upregulated, whereas those of seven miRNAs (hsa-miRNA-21-5p, hsa-miRNA-195-5p, hsa-miRNA-19a-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p and hsa-let-7a-5p) were downregulated, compared with the corresponding isolated normal gland specimens. In the isolated CRC stromal cells, the expression levels of three miRNAs (hsa-miRNA-21-5p, hsa-miRNA-31-5p and hsa-miRNA-27b-3p) were upregulated and those of 10 miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-195-5p, hsa-miRNA-19a-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p, hsa-let-7a-5p and hsa-miRNA-27a-3p) were downregulated compared with the corresponding normal fibroblasts. Finally, in the intact tumor mucosa samples, the expression levels of three miRNAs (hsa-miRNA-31-5p, hsa-miRNA-19a-3p and hsa-let-7a-5p) were upregulated, and those of 10 miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-21-5p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-195-5p, hsa-miRNA-27b-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p and hsa-miRNA-27a-3p) were downregulated, compared with normal mucosa specimens. +tissue_expression_down 31750597 hsa-mir-34b Colorectal Neoplasms In isolated CRC gland cells, the expression levels of six miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-31-5p, hsa-miRNA-27b-3p and hsa-miRNA-27a-3p) were upregulated, whereas those of seven miRNAs (hsa-miRNA-21-5p, hsa-miRNA-195-5p, hsa-miRNA-19a-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p and hsa-let-7a-5p) were downregulated, compared with the corresponding isolated normal gland specimens. In the isolated CRC stromal cells, the expression levels of three miRNAs (hsa-miRNA-21-5p, hsa-miRNA-31-5p and hsa-miRNA-27b-3p) were upregulated and those of 10 miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-195-5p, hsa-miRNA-19a-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p, hsa-let-7a-5p and hsa-miRNA-27a-3p) were downregulated compared with the corresponding normal fibroblasts. Finally, in the intact tumor mucosa samples, the expression levels of three miRNAs (hsa-miRNA-31-5p, hsa-miRNA-19a-3p and hsa-let-7a-5p) were upregulated, and those of 10 miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-21-5p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-195-5p, hsa-miRNA-27b-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p and hsa-miRNA-27a-3p) were downregulated, compared with normal mucosa specimens. +tissue_expression_up 31750597 hsa-mir-27a Colorectal Neoplasms In isolated CRC gland cells, the expression levels of six miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-31-5p, hsa-miRNA-27b-3p and hsa-miRNA-27a-3p) were upregulated, whereas those of seven miRNAs (hsa-miRNA-21-5p, hsa-miRNA-195-5p, hsa-miRNA-19a-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p and hsa-let-7a-5p) were downregulated, compared with the corresponding isolated normal gland specimens. In the isolated CRC stromal cells, the expression levels of three miRNAs (hsa-miRNA-21-5p, hsa-miRNA-31-5p and hsa-miRNA-27b-3p) were upregulated and those of 10 miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-195-5p, hsa-miRNA-19a-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p, hsa-let-7a-5p and hsa-miRNA-27a-3p) were downregulated compared with the corresponding normal fibroblasts. Finally, in the intact tumor mucosa samples, the expression levels of three miRNAs (hsa-miRNA-31-5p, hsa-miRNA-19a-3p and hsa-let-7a-5p) were upregulated, and those of 10 miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-21-5p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-195-5p, hsa-miRNA-27b-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p and hsa-miRNA-27a-3p) were downregulated, compared with normal mucosa specimens. +tissue_expression_up 31750597 hsa-mir-1 Colorectal Neoplasms In isolated CRC gland cells, the expression levels of six miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-31-5p, hsa-miRNA-27b-3p and hsa-miRNA-27a-3p) were upregulated, whereas those of seven miRNAs (hsa-miRNA-21-5p, hsa-miRNA-195-5p, hsa-miRNA-19a-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p and hsa-let-7a-5p) were downregulated, compared with the corresponding isolated normal gland specimens. In the isolated CRC stromal cells, the expression levels of three miRNAs (hsa-miRNA-21-5p, hsa-miRNA-31-5p and hsa-miRNA-27b-3p) were upregulated and those of 10 miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-195-5p, hsa-miRNA-19a-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p, hsa-let-7a-5p and hsa-miRNA-27a-3p) were downregulated compared with the corresponding normal fibroblasts. Finally, in the intact tumor mucosa samples, the expression levels of three miRNAs (hsa-miRNA-31-5p, hsa-miRNA-19a-3p and hsa-let-7a-5p) were upregulated, and those of 10 miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-21-5p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-195-5p, hsa-miRNA-27b-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p and hsa-miRNA-27a-3p) were downregulated, compared with normal mucosa specimens. +tissue_expression_down 31750597 hsa-mir-19a Colorectal Neoplasms In isolated CRC gland cells, the expression levels of six miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-31-5p, hsa-miRNA-27b-3p and hsa-miRNA-27a-3p) were upregulated, whereas those of seven miRNAs (hsa-miRNA-21-5p, hsa-miRNA-195-5p, hsa-miRNA-19a-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p and hsa-let-7a-5p) were downregulated, compared with the corresponding isolated normal gland specimens. In the isolated CRC stromal cells, the expression levels of three miRNAs (hsa-miRNA-21-5p, hsa-miRNA-31-5p and hsa-miRNA-27b-3p) were upregulated and those of 10 miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-195-5p, hsa-miRNA-19a-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p, hsa-let-7a-5p and hsa-miRNA-27a-3p) were downregulated compared with the corresponding normal fibroblasts. Finally, in the intact tumor mucosa samples, the expression levels of three miRNAs (hsa-miRNA-31-5p, hsa-miRNA-19a-3p and hsa-let-7a-5p) were upregulated, and those of 10 miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-21-5p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-195-5p, hsa-miRNA-27b-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p and hsa-miRNA-27a-3p) were downregulated, compared with normal mucosa specimens. +tissue_expression_down 31750597 hsa-let-7a Colorectal Neoplasms In isolated CRC gland cells, the expression levels of six miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-31-5p, hsa-miRNA-27b-3p and hsa-miRNA-27a-3p) were upregulated, whereas those of seven miRNAs (hsa-miRNA-21-5p, hsa-miRNA-195-5p, hsa-miRNA-19a-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p and hsa-let-7a-5p) were downregulated, compared with the corresponding isolated normal gland specimens. In the isolated CRC stromal cells, the expression levels of three miRNAs (hsa-miRNA-21-5p, hsa-miRNA-31-5p and hsa-miRNA-27b-3p) were upregulated and those of 10 miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-195-5p, hsa-miRNA-19a-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p, hsa-let-7a-5p and hsa-miRNA-27a-3p) were downregulated compared with the corresponding normal fibroblasts. Finally, in the intact tumor mucosa samples, the expression levels of three miRNAs (hsa-miRNA-31-5p, hsa-miRNA-19a-3p and hsa-let-7a-5p) were upregulated, and those of 10 miRNAs (hsa-miRNA-130a-3p, hsa-miRNA-21-5p, hsa-miRNA-143-3p, hsa-miRNA-206, hsa-miRNA-195-5p, hsa-miRNA-27b-3p, hsa-miRNA-34b-3p, hsa-miRNA-186-5p, hsa-miRNA-191-5p and hsa-miRNA-27a-3p) were downregulated, compared with normal mucosa specimens. +other 31750260 hsa-mir-25 Coronary Disease Our findings suggest that the miR-25/KLF2 axis may be a potential therapeutic target for H. pylori-associated CHD. +circulation_biomarker_diagnosis_down 31750241 hsa-mir-150 Colorectal Neoplasms The serum exosomal miR-99b-5p and miR +circulation_biomarker_diagnosis_down 31750241 hsa-mir-99b Colorectal Neoplasms The serum exosomal miR-99b-5p and miR +other 31749884 hsa-mir-141 Carcinoma, Non-Small-Cell Lung 3p. +lncRNA target 31749878 hsa-mir-21 Arteriosclerosis Obliterans The present study aimed to indicate the potential roles of miR-21 in ASO processes, and the results provided a novel therapeutic approach for treating ASO and new targets for preventing ASO in earlier stages. +circulation_biomarker_diagnosis_up 31749873 hsa-mir-122a Carcinoma, Hepatocellular Our results suggest that serum miR-122 might serve as a novel and potential noninvasive biomarker for HCV-induced HCC. +circulation_biomarker_diagnosis_up 31749873 hsa-mir-139 Carcinoma, Hepatocellular RESULTS: Serum levels of miRNA-122a, miRNA-125a, miRNA-139, miRNA-145, and miRNA-199a were significantly lower (p < 0.01) in HCC than in CHC and LC groups. CONCLUSIONS: These findings indicate that measurement of serum levels of miRNA-122a, miRNA-125a, miRNA-139, miRNA-145, and miRNA-199a can differentiate HCC from CHC and LC. +circulation_biomarker_diagnosis_up 31749873 hsa-mir-199a Carcinoma, Hepatocellular RESULTS: Serum levels of miRNA-122a, miRNA-125a, miRNA-139, miRNA-145, and miRNA-199a were significantly lower (p < 0.01) in HCC than in CHC and LC groups. CONCLUSIONS: These findings indicate that measurement of serum levels of miRNA-122a, miRNA-125a, miRNA-139, miRNA-145, and miRNA-199a can differentiate HCC from CHC and LC. +circulation_biomarker_diagnosis_up 31749873 hsa-mir-145 Carcinoma, Hepatocellular RESULTS: Serum levels of miRNA-122a, miRNA-125a, miRNA-139, miRNA-145, and miRNA-199a were significantly lower (p < 0.01) in HCC than in CHC and LC groups. CONCLUSIONS: These findings indicate that measurement of serum levels of miRNA-122a, miRNA-125a, miRNA-139, miRNA-145, and miRNA-199a can differentiate HCC from CHC and LC. +circulation_biomarker_diagnosis_up 31749873 hsa-mir-125a Carcinoma, Hepatocellular RESULTS: Serum levels of miRNA-122a, miRNA-125a, miRNA-139, miRNA-145, and miRNA-199a were significantly lower (p < 0.01) in HCC than in CHC and LC groups. CONCLUSIONS: These findings indicate that measurement of serum levels of miRNA-122a, miRNA-125a, miRNA-139, miRNA-145, and miRNA-199a can differentiate HCC from CHC and LC. +other 31749661 hsa-mir-363 Gastrointestinal Stromal Tumors 3P contribute to the metastasis of GISTs in vitro by mediating the SNAI2/CDH1 axis. +other 31749661 hsa-mir-200b Gastrointestinal Stromal Tumors 3P contribute to the metastasis of GISTs in vitro by mediating the SNAI2/CDH1 axis. +lncRNA target 31749660 hsa-mir-96 Thyroid Cancer, Papillary 3p is involved in PTC metastasis and invasion by direct targeting SDHB and the downstream molecule AKT and mTOR. +other 31749630 hsa-mir-21 Breast Neoplasms PURPOSE: MiR-21 and miR-451 are closely associated with tumor initiation, drug resistance, and recurrence of breast cancer (BC). +circulation_biomarker_diagnosis_ns 31749630 hsa-mir-451 Breast Neoplasms However, plasma miR-451 lacks enough sensitivity in the detection of primary and recurrent BC, and more studies are needed in this area. +other 31749597 hsa-mir-19b-1 Inflammatory Bowel Diseases Dysregulation of circRNA_103516 may participate in the molecular mechanism of IBD through hsa-miR-19b-1-5p sponging. +other 31749593 hsa-mir-32 Pediatric Enteritis AIM: To investigate the role of aberrant miR5p in pediatric enteritis induced by H. +lncRNA target 31749335 hsa-mir-21 Atrial Fibrillation In conclusion, this study revealed that CYP2J2/EET ameliorates atrial fibrosis through modulating atrial fibroblasts activation by disinhibition of MiR-21 on Smad-7, and attenuates atrial inflammatory response by repressing NF-kappaB pathways, reducing the vulnerability to AF, and CYP2J2/EET exerts its role at least partially through PPAR-gamma activation. +tissue_expression_up 31749272 hsa-mir-342 Pre-Eclampsia The expression of miR-342-3p was upregulated in both basal plates and chorionic plates in patients with PE compared with healthy pregnant individuals. +tissue_expression_down 31749230 hsa-mir-630 lung non-small cell carcinoma Knockdown of circMTDH.4 and/or overexpression of miR-630 inhibited chemoresistance and radioresistance in NSCLC cells, whereas overexpression of AEG-1 or knockdown of miR-630 exerted rescue effects. +other 31749176 hsa-mir-206 Asthenozoospermia The present study demonstrated that hsa-miR-27b-3p, hsa-miR-151a-5p and hsa-miR-206 play an important role in the effects of l-carnitine treatment of the spermatozoa in asthenospermia patients. +other 31749176 hsa-mir-151a Asthenozoospermia The present study demonstrated that hsa-miR-27b-3p, hsa-miR-151a-5p and hsa-miR-206 play an important role in the effects of l-carnitine treatment of the spermatozoa in asthenospermia patients. +other 31749176 hsa-mir-27b Asthenozoospermia The present study demonstrated that hsa-miR-27b-3p, hsa-miR-151a-5p and hsa-miR-206 play an important role in the effects of l-carnitine treatment of the spermatozoa in asthenospermia patients. +other 31749032 hsa-mir-608 Sepsis These results suggest that miR-608 is an important posttranscriptional regulator of ELANE expression in human monocytes and may play an important role in the process of inflammation. miR-608 and neutrophil elastase may be novel targets for the diagnosis or treatment of sepsis. +other 31748847 hsa-mir-23b Atherosclerosis Our previous study has demonstrated that miR-23b enhances oxidized low-density lipoprotein (oxLDL)-induced inflammatory response of macrophages through the A20/NF-kappaB signaling pathway, thus contributing to atherosclerosis +tissue_expression_up 31748508 hsa-mir-454 Triple Negative Breast Neoplasms High expression of miR-454 may be one of the causes of the downregulation of VGLL4 in TNBC +other 31747939 hsa-mir-137 Pancreatic Neoplasms OTUD7B mediates EGFR and MAPK signaling pathway, suggesting that linc00976/miR-137/OTUD7B/EGFR axis may act as a potential biomarker and therapeutic target for PC. +other 31747809 hsa-mir-17 Endometriosis MiR-17-5p might be a bio- marker of endometriosis +tissue_expression_ns 31747595 hsa-mir-181a Ataxia Neuropathy Spectrum We found that miR-181a deficiency delays viral clearance, thereby biasing the immune response in favor of CD4 over CD8 T cells. +other 31747409 hsa-mir-200 Breast Neoplasms Here, we describe two miR-200c inducible breast cancer cell lines, derived from miR-200c knock-out MCF7 cells as well as from the miR-200c-negative MDA-MB-231 cells and report on the emerging phenotypic effects after miR-200s induction. +other 31747409 hsa-mir-200c Breast Neoplasms Here, we describe two miR-200c inducible breast cancer cell lines, derived from miR-200c knock-out MCF7 cells as well as from the miR-200c-negative MDA-MB-231 cells and report on the emerging phenotypic effects after miR-200s induction. +tissue_expression_down 31747378 hsa-mir-144 Endometrial Neoplasms Overexpression of miR-144-3p suppressed the proliferation and invasion of EC cells. +other 31747371 hsa-mir-382 Colorectal Neoplasms Mechanistic study revealed that hsa_circ_0001178 acted as a competing endogenous RNA (ceRNA) for miR-382/587/616 to upregulate ZEB1 (a key trigger of epithelial-to-mesenchymal transition), thereby promoting CRC metastatic dissemination. +other 31747371 hsa-mir-616 Colorectal Neoplasms Mechanistic study revealed that hsa_circ_0001178 acted as a competing endogenous RNA (ceRNA) for miR-382/587/616 to upregulate ZEB1 (a key trigger of epithelial-to-mesenchymal transition), thereby promoting CRC metastatic dissemination. +other 31747371 hsa-mir-587 Colorectal Neoplasms Mechanistic study revealed that hsa_circ_0001178 acted as a competing endogenous RNA (ceRNA) for miR-382/587/616 to upregulate ZEB1 (a key trigger of epithelial-to-mesenchymal transition), thereby promoting CRC metastatic dissemination. +other 31746531 hsa-mir-182 Carcinoma, Hepatocellular Taken together, P7TP3, the direct target gene of miR-182-5p, inhibited HCC by regulating migration, invasion, adhesion, proliferation and cell cycle progression of liver cancer cell through the Wnt/beta-catenin signaling pathway. +circulation_biomarker_diagnosis_ns 31746515 hsa-mir-132 Epilepsy, Generalized Combined miR-146a, miR-155 and miR-132 serum levels performed well as a diagnostic biomarker, discriminating GGE patients from controls with an area under the curve of 0.85, 80% specificity and 73% sensitivity. +other 31746439 hsa-mir-210 Carcinoma, Non-Small-Cell Lung miR215p, miR193b3p, miR2103p and miR315p may therefore serve as important biomarkers and diagnostic targets for NSCLC. +other 31746439 hsa-mir-21 Carcinoma, Non-Small-Cell Lung miR215p, miR193b3p, miR2103p and miR315p may therefore serve as important biomarkers and diagnostic targets for NSCLC. +other 31746439 hsa-mir-1 Carcinoma, Non-Small-Cell Lung miR215p, miR193b3p, miR2103p and miR315p may therefore serve as important biomarkers and diagnostic targets for NSCLC. +other 31746439 hsa-mir-193b Carcinoma, Non-Small-Cell Lung miR215p, miR193b3p, miR2103p and miR315p may therefore serve as important biomarkers and diagnostic targets for NSCLC. +tissue_expression_down 31746434 hsa-mir-4656 Prostatic Neoplasms MiR4656 was found to be decreased in prostate cancer tissues +tissue_expression_down 31746422 hsa-mir-101 Osteosarcoma SPRY4IT1 inhibition increased miR101 levels, resulting in downregulation of ZEB1/2 expression and thus exerting antitumour effects in OS. +genetics_knock down_promote 31746418 hsa-mir-154 Neuralgia MALAT1 knockdown in CCI model rats significantly induced the occurrence of neuropathic pain, while the upregulation of miR1545p could reverse this process. +other 31746410 hsa-mir-150 Breast Neoplasms Receiver operating characteristic curve analyses indicated that miR1505p [area under the curve (AUC)=0.705, upregulated], miR5763p (AUC=0.691, upregulated), miR46655p (AUC=0.681, upregulated) were able to distinguish breast cancer patients with recurrence from those without recurrence. +other 31746410 hsa-mir-4665 Breast Neoplasms Receiver operating characteristic curve analyses indicated that miR1505p [area under the curve (AUC)=0.705, upregulated], miR5763p (AUC=0.691, upregulated), miR46655p (AUC=0.681, upregulated) were able to distinguish breast cancer patients with recurrence from those without recurrence. +other 31746391 hsa-mir-218 Uterine Cervical Neoplasms miR218 is downregulated in cervical cancer tissues. +other 31746384 hsa-mir-885 Carcinoma, Renal Cell miR213p, miR1553p, miR1443p, miR1425p, miR8753p, miR8853p, miR3941, miR2243p, miR5843p and miR13813p, were significantly associated with CCRCC survival. +other 31746384 hsa-mir-875 Carcinoma, Renal Cell miR213p, miR1553p, miR1443p, miR1425p, miR8753p, miR8853p, miR3941, miR2243p, miR5843p and miR13813p, were significantly associated with CCRCC survival. +other 31746384 hsa-mir-155 Carcinoma, Renal Cell miR213p, miR1553p, miR1443p, miR1425p, miR8753p, miR8853p, miR3941, miR2243p, miR5843p and miR13813p, were significantly associated with CCRCC survival. +other 31746384 hsa-mir-584 Carcinoma, Renal Cell miR213p, miR1553p, miR1443p, miR1425p, miR8753p, miR8853p, miR3941, miR2243p, miR5843p and miR13813p, were significantly associated with CCRCC survival. +other 31746384 hsa-mir-224 Carcinoma, Renal Cell miR213p, miR1553p, miR1443p, miR1425p, miR8753p, miR8853p, miR3941, miR2243p, miR5843p and miR13813p, were significantly associated with CCRCC survival. +other 31746384 hsa-mir-144 Carcinoma, Renal Cell miR213p, miR1553p, miR1443p, miR1425p, miR8753p, miR8853p, miR3941, miR2243p, miR5843p and miR13813p, were significantly associated with CCRCC survival. +other 31746384 hsa-mir-1381 Carcinoma, Renal Cell miR213p, miR1553p, miR1443p, miR1425p, miR8753p, miR8853p, miR3941, miR2243p, miR5843p and miR13813p, were significantly associated with CCRCC survival. +other 31746384 hsa-mir-941 Carcinoma, Renal Cell miR213p, miR1553p, miR1443p, miR1425p, miR8753p, miR8853p, miR3941, miR2243p, miR5843p and miR13813p, were significantly associated with CCRCC survival. +other 31746384 hsa-mir-142 Carcinoma, Renal Cell miR213p, miR1553p, miR1443p, miR1425p, miR8753p, miR8853p, miR3941, miR2243p, miR5843p and miR13813p, were significantly associated with CCRCC survival. +other 31746384 hsa-mir-21 Carcinoma, Renal Cell miR213p, miR1553p, miR1443p, miR1425p, miR8753p, miR8853p, miR3941, miR2243p, miR5843p and miR13813p, were significantly associated with CCRCC survival. +tissue_expression_down 31746372 hsa-mir-718 Carcinoma, Non-Small-Cell Lung These results indicated that miR718 suppressed NSCLC progression in vitro and in vivo by directly targeting CCNB1 mRNA +other 31746360 hsa-mir-411 Uterine Cervical Neoplasms These findings indicate that the miR411mediated direct suppression of STK17A induces apoptosis and suppresses the proliferation, migration and invasion of human cervical cancer cells via the p53 signaling pathway. +lncRNA target 31746345 hsa-mir-342 Fibrosis, Renal Thus, the miR3423p/SOX6 axis may serve as a novel therapeutic target in the treatment of DKD. +lncRNA target 31746345 hsa-mir-342 Diabetic Nephropathies Thus, the miR3423p/SOX6 axis may serve as a novel therapeutic target in the treatment of DKD. +other 31746333 hsa-mir-377 Urinary Bladder Neoplasms our results illuminated that circZFR could be a prognostic biomarker in bladder cancer and exerted oncogenic roles through regulating miR-377/ZEB2 axis in bladder cancer +genetics_knock down_promote 31746331 hsa-mir-132 Influenza, Human Meanwhile, overexpression of miR +tissue_expression_down 31746301 hsa-mir-4319 Esophageal Squamous Cell Carcinoma The miR-4319 expression was lower in ESCC cells than in the normal cell line. +other 31746054 hsa-mir-125b Colonic Neoplasms miR-125b-5p overexpression markedly reversed drug resistance and inhibited epithelial-mesenchymal transition in colon cancer cells. +tissue_expression_up 31746031 hsa-mir-501 Stomach Neoplasms And, the Cell Counting Kit-8 colony formation and cell migration assay results showed that the downregulation of miR-501-5p decreased GC cell proliferation and migration. +lncRNA target 31745609 hsa-mir-21 Adenocarcinoma The biosensor was applied to the analysis of miR-21 from total RNA (RNA(t)) extracted from epithelial non-tumorigenic and adenocarcinoma breast cells without target amplification, pre-concentration, or reverse transcription steps. +other 31744543 hsa-mir-126 familial erythrocytosis 2 By performing a series of experiments including miRNA sequencing and ChIP (chromatin immunoprecipitation)-PCR, we found that miR-126 is directly induced by ETV2. +tissue_expression_down 31744497 hsa-mir-451 Endometriosis Hsa-miR-451 in FF was downregulated in endometriosis patients relative to control subjects (P < 0.01). +genetics_knock down_suppress 31744257 hsa-let-7d Leiomyosarcoma, Uterine In conclusion, all the let-7 family members were downregulated in LMS patients, and the greater the loss of expression of these molecules, the greater their relationship with worse prognosis of patients. +other 31744257 hsa-let-7c Leiomyosarcoma, Uterine We aimed to evaluate the expression profile of let-7a, let-7b, let-7c, let-7d, let-7e, let-7f, let-7g, and let-7i and to assess their value as prognostic markers in uterine leiomyosarcoma (LMS) patients. +other 31744257 hsa-let-7i Leiomyosarcoma, Uterine We aimed to evaluate the expression profile of let-7a, let-7b, let-7c, let-7d, let-7e, let-7f, let-7g, and let-7i and to assess their value as prognostic markers in uterine leiomyosarcoma (LMS) patients. +other 31744257 hsa-let-7g Leiomyosarcoma, Uterine We aimed to evaluate the expression profile of let-7a, let-7b, let-7c, let-7d, let-7e, let-7f, let-7g, and let-7i and to assess their value as prognostic markers in uterine leiomyosarcoma (LMS) patients. +other 31744257 hsa-let-7b Leiomyosarcoma, Uterine We aimed to evaluate the expression profile of let-7a, let-7b, let-7c, let-7d, let-7e, let-7f, let-7g, and let-7i and to assess their value as prognostic markers in uterine leiomyosarcoma (LMS) patients. +other 31744257 hsa-let-7e Leiomyosarcoma, Uterine We aimed to evaluate the expression profile of let-7a, let-7b, let-7c, let-7d, let-7e, let-7f, let-7g, and let-7i and to assess their value as prognostic markers in uterine leiomyosarcoma (LMS) patients. +other 31744257 hsa-let-7a Leiomyosarcoma, Uterine We aimed to evaluate the expression profile of let-7a, let-7b, let-7c, let-7d, let-7e, let-7f, let-7g, and let-7i and to assess their value as prognostic markers in uterine leiomyosarcoma (LMS) patients. +other 31744257 hsa-let-7f Leiomyosarcoma, Uterine We aimed to evaluate the expression profile of let-7a, let-7b, let-7c, let-7d, let-7e, let-7f, let-7g, and let-7i and to assess their value as prognostic markers in uterine leiomyosarcoma (LMS) patients. +tissue_expression_up 31744065 hsa-mir-196b Colonic Neoplasms It down-regulated 8 miRNAs (miR-155, miR-210, miR-144, miR-194, miR-26b, miR-126, miR-302c, and miR-29a) and up-regulated 2 miRNAs (miR-223 and miR-196b). +tissue_expression_down 31744065 hsa-mir-29a Colonic Neoplasms It down-regulated 8 miRNAs (miR-155, miR-210, miR-144, miR-194, miR-26b, miR-126, miR-302c, and miR-29a) and up-regulated 2 miRNAs (miR-223 and miR-196b). +tissue_expression_down 31744065 hsa-mir-144 Colonic Neoplasms It down-regulated 8 miRNAs (miR-155, miR-210, miR-144, miR-194, miR-26b, miR-126, miR-302c, and miR-29a) and up-regulated 2 miRNAs (miR-223 and miR-196b). +tissue_expression_down 31744065 hsa-mir-155 Colonic Neoplasms It down-regulated 8 miRNAs (miR-155, miR-210, miR-144, miR-194, miR-26b, miR-126, miR-302c, and miR-29a) and up-regulated 2 miRNAs (miR-223 and miR-196b). +tissue_expression_down 31744065 hsa-mir-210 Colonic Neoplasms It down-regulated 8 miRNAs (miR-155, miR-210, miR-144, miR-194, miR-26b, miR-126, miR-302c, and miR-29a) and up-regulated 2 miRNAs (miR-223 and miR-196b). +tissue_expression_down 31744065 hsa-mir-194 Colonic Neoplasms It down-regulated 8 miRNAs (miR-155, miR-210, miR-144, miR-194, miR-26b, miR-126, miR-302c, and miR-29a) and up-regulated 2 miRNAs (miR-223 and miR-196b). +tissue_expression_down 31744065 hsa-mir-126 Colonic Neoplasms It down-regulated 8 miRNAs (miR-155, miR-210, miR-144, miR-194, miR-26b, miR-126, miR-302c, and miR-29a) and up-regulated 2 miRNAs (miR-223 and miR-196b). +tissue_expression_up 31744065 hsa-mir-223 Colonic Neoplasms It down-regulated 8 miRNAs (miR-155, miR-210, miR-144, miR-194, miR-26b, miR-126, miR-302c, and miR-29a) and up-regulated 2 miRNAs (miR-223 and miR-196b). +tissue_expression_down 31744065 hsa-mir-26b Colonic Neoplasms It down-regulated 8 miRNAs (miR-155, miR-210, miR-144, miR-194, miR-26b, miR-126, miR-302c, and miR-29a) and up-regulated 2 miRNAs (miR-223 and miR-196b). +other 31743914 hsa-mir-519a Stomach Neoplasms we found that miR-519a was an important tumor suppressor with downregulated expression in GC tissues and cells compared with that in normal controls (all p < 0.05). +other 31743855 hsa-mir-223 Myocarditis 3p is involved in the induction of the tolerogenic DC phenotype and regulates tolerance in autoimmune myocarditis. +other 31743769 hsa-mir-195 Osteosarcoma lncSNHG12 silencing inhibited OS metastasis and growth by targeting the miR-195-5p/IGF1R axis, which represents a candidate marker and target for OS treatment and management. +circulation_biomarker_diagnosis_up 31743768 hsa-mir-24 Nasopharyngeal Carcinoma Five miRNAs in serum including let-7b-5p, miR-140-3p, miR-192-5p, miR-223-3p and miR-24-3p were found to be significantly up-regulated in NPC patients compared to NCs. +circulation_biomarker_diagnosis_up 31743768 hsa-mir-223 Nasopharyngeal Carcinoma Five miRNAs in serum including let-7b-5p, miR-140-3p, miR-192-5p, miR-223-3p and miR-24-3p were found to be significantly up-regulated in NPC patients compared to NCs. +circulation_biomarker_diagnosis_up 31743768 hsa-mir-140 Nasopharyngeal Carcinoma Five miRNAs in serum including let-7b-5p, miR-140-3p, miR-192-5p, miR-223-3p and miR-24-3p were found to be significantly up-regulated in NPC patients compared to NCs. +circulation_biomarker_diagnosis_up 31743768 hsa-mir-192 Nasopharyngeal Carcinoma Five miRNAs in serum including let-7b-5p, miR-140-3p, miR-192-5p, miR-223-3p and miR-24-3p were found to be significantly up-regulated in NPC patients compared to NCs. +circulation_biomarker_diagnosis_up 31743768 hsa-let-7b Nasopharyngeal Carcinoma Five miRNAs in serum including let-7b-5p, miR-140-3p, miR-192-5p, miR-223-3p and miR-24-3p were found to be significantly up-regulated in NPC patients compared to NCs. +circulation_biomarker_diagnosis_down 31743617 hsa-mir-1 Heart Failure Effects of aerobic and inspiratory training on skeletal muscle microRNA-1 and downstream-associated pathways in patients with heart failure. We hypothesized that (i) aerobic exercise training (AET) and inspiratory muscle training (IMT) would change skeletal muscle microRNA-1 expression and downstream-associated pathways in patients with HFrEF and (ii) AET and IMT would increase leg blood flow (LBF), functional capacity, and quality of life in these patients. +lncRNA target 31743528 hsa-mir-124 Alzheimer Disease Silencing of lncRNA XIST attenuated AD-related BACE1 alteration through miR-124. +circulation_biomarker_diagnosis_up 31743302 hsa-mir-370 Sepsis-Associated Encephalopathy Our pilot results in patients with SAE supported the possibility that plasma miR +other 31743132 hsa-mir-196a Esophageal Neoplasms miR-196a inhibition can increase the caspase level and induce esophageal cancer cell apoptosis +tissue_expression_down 31742924 hsa-mir-148a Esophageal Squamous Cell Carcinoma The mRNA expression of TUG1 was significantly upregulated in ESCC tissues or cells, and was negatively correlated to miR-148a-3p expression in tissues. +other 31742868 hsa-mir-34a Triple Negative Breast Neoplasms These data validate that miR-34a delivery can impair TNBC cell function and support continued investigation of this platform for treatment of TNBC. +other 31742752 hsa-mir-873 Carcinoma, Non-Small-Cell Lung lncRNA TDRG1 facilitates the progression of NSCLC via interacting with miR-873-5p and positively regulates the expression of ZEB1. +tissue_expression_down 31742423 hsa-mir-539 Breast Neoplasms we found that miR-539 was down-regulated in breast cancer tissues and cell lines. +genetics_overexpression_promote 31742336 hsa-mir-206 Carcinoma, Non-Small-Cell Lung miR-206 overexpression downregulated the expression of HK2 via targeting HK2 3'UTR in NSCLC cells. +lncRNA target 31741467 hsa-mir-149 Myocardial Reperfusion Injury Over-expression of miR-149 inhibited cell viability and promote pyroptosis, however, down-expression of miR-149 had an opposite effect in I/R treated H9C2 cells. +exosome 31740975 hsa-mir-10b Stomach Neoplasms In the following bioinformatic analysis of exosomal miRNAs, three candidates were proposed as the biomarkers for metastasis of gastric cancer, namely miR-10b-5p, miR +exosome 31740975 hsa-mir-101 Stomach Neoplasms In the following bioinformatic analysis of exosomal miRNAs, three candidates were proposed as the biomarkers for metastasis of gastric cancer, namely miR-10b-5p, miR +exosome 31740975 hsa-mir-143 Stomach Neoplasms In the following bioinformatic analysis of exosomal miRNAs, three candidates were proposed as the biomarkers for metastasis of gastric cancer, namely miR-10b-5p, miR +other 31740780 hsa-mir-940 Carcinoma, Hepatocellular we found that overexpression of H1HR was mainly due to the downregulation of miR-940 in HCC cells. +transcription factor target 31740746 hsa-mir-4715 Gastrointestinal Neoplasms Inhibition of AURKA or reconstitution of miR3p inhibited GPX4 and induced cell death, suggesting a link between AURKA and ferroptosis. +other 31740664 hsa-mir-1290 Ischemia These findings suggested that ischemia likely upregulates Cav-1 expression in neurons to increase EV intake, which protects neurons by attenuating apoptosis via miR-1290. +other 31740654 hsa-mir-652 Uveal melanoma RT-qPCR showed that miR-652 was overexpressed in uveal melanoma cell lines (MUM-2B, MEL270) compared with melanocyte cells (ARPE-19). +transcription factor target 31740576 hsa-mir-137 Substance-Related Disorders These novel results highlight miR-137 as a potential therapeutic target for anxiety and AUD susceptibility after adolescent alcohol exposure in adulthood. +genetics_GWAS 31740576 hsa-mir-137 Anxiety Disorders We investigated the role of microRNA-137 (miR-137), which is crucial for normal neurodevelopment and targets LSD1, in adolescent intermittent ethanol (AIE) exposure-induced anxiety-like and alcohol-drinking behaviors and related epigenetic reprogramming in the amygdala in adulthood. +genetics_GWAS 31740576 hsa-mir-137 Acrodermatitis enteropathica We investigated the role of microRNA-137 (miR-137), which is crucial for normal neurodevelopment and targets LSD1, in adolescent intermittent ethanol (AIE) exposure-induced anxiety-like and alcohol-drinking behaviors and related epigenetic reprogramming in the amygdala in adulthood. +other 31739406 hsa-mir-146a Arthritis, Rheumatoid Using miRNA-sequencing on S100A8/A9-P-stimulated differentiated HL-60 cells, we identified a dysregulation of miR-146a-5p and miR-155-5p expression through TRL4 signaling pathways. +other 31739406 hsa-mir-155 Arthritis, Rheumatoid Using miRNA-sequencing on S100A8/A9-P-stimulated differentiated HL-60 cells, we identified a dysregulation of miR-146a-5p and miR-155-5p expression through TRL4 signaling pathways. +other 31739288 hsa-mir-425 Breast Neoplasms Overexpression of miR-425 attenuated the LINC00899-induced inhibition of breast cancer cell proliferation and invasion. +other 31739284 hsa-mir-1226 Sarcoma this study illustrated the potential mechanism of hsa-miR-1226-3p regulating MUC1 and dendritic cells resting might play an important role in STS recurrence. +other 31739210 hsa-mir-128 Colonic Neoplasms 3p/VEGF-C and Smad4/VEGF-C pathways in non-metastatic and metastatic colon cancer, respectively. +other 31739209 hsa-mir-214 Osteonecrosis AAV-anti-miR-214 promoted osteoblast activity and diminished osteoclast activity, effectively preventing collapse of the femoral head in a rat model of osteonecrosis. +transcription factor target 31739105 hsa-mir-135a Cardiomyopathies AIM OF THE STUDY: The objective of this article is to investigate the inhibition effect of ASG on cardiac fibrosis through the miR-135a-TRPM7-TGF-beta/Smads pathway. ASG inhibited cardiac fibrosis by targeting the miR-135a-TRPM7-TGF-beta/Smads pathway. +other 31739067 hsa-mir-29b Lichen Planus, Oral elevated miR-29b interacts with IFN-gamma via a regulatory feedback loop and induces global DNA hypomethylation in CD4(+) T cells, which consequently modulates Type 1 T helper immune response, thus contributing to the immune dysregulation of OLP. +tissue_expression_down 31738908 hsa-mir-143 Thyroid Cancer, Papillary Our results indicate that upregulation of miR-143-3p suppresses the progression of PTC by impeding cell growth, invasion, and migration via downregulation of MSI2, highlighting the potential of miR-143-3p as a target for future PTC treatment. +genetics_GWAS 31738890 hsa-mir-146a Schizophrenia The CG and GG hsa-miR-146a genotypes were associated with increased risk of both schizophrenia +circulation_biomarker_diagnosis_ns 31738788 hsa-mir-221 Ovarian Neoplasms Four up-regulated (miR-200c-3p, miR-221-3p, miR-21-5p, and miR-484) and two down-regulated (miR-195-5p and miR-451a) microRNAs were discovered. +circulation_biomarker_diagnosis_ns 31738788 hsa-mir-484 Ovarian Neoplasms Four up-regulated (miR-200c-3p, miR-221-3p, miR-21-5p, and miR-484) and two down-regulated (miR-195-5p and miR-451a) microRNAs were discovered. +circulation_biomarker_diagnosis_ns 31738788 hsa-mir-195 Ovarian Neoplasms Four up-regulated (miR-200c-3p, miR-221-3p, miR-21-5p, and miR-484) and two down-regulated (miR-195-5p and miR-451a) microRNAs were discovered. +circulation_biomarker_diagnosis_ns 31738788 hsa-mir-21 Ovarian Neoplasms Four up-regulated (miR-200c-3p, miR-221-3p, miR-21-5p, and miR-484) and two down-regulated (miR-195-5p and miR-451a) microRNAs were discovered. +circulation_biomarker_diagnosis_ns 31738788 hsa-mir-200c Ovarian Neoplasms Four up-regulated (miR-200c-3p, miR-221-3p, miR-21-5p, and miR-484) and two down-regulated (miR-195-5p and miR-451a) microRNAs were discovered. +circulation_biomarker_diagnosis_ns 31738788 hsa-mir-451a Ovarian Neoplasms Four up-regulated (miR-200c-3p, miR-221-3p, miR-21-5p, and miR-484) and two down-regulated (miR-195-5p and miR-451a) microRNAs were discovered. +lncRNA target 31738412 hsa-mir-17 Myocardial Infarction Additionally, RAPA suppressed the pro-apoptotic prolyl hydroxylase (Egln3/PHD3), a target of miRNA-17/20a in diabetic hearts, which was abrogated in miRNA +lncRNA target 31738412 hsa-mir-17 Diabetes Mellitus Additionally, RAPA suppressed the pro-apoptotic prolyl hydroxylase (Egln3/PHD3), a target of miRNA-17/20a in diabetic hearts, which was abrogated in miRNA +other 31738404 hsa-mir-96 Prostatic Neoplasms We propose that miR-96 promotes bone metastasis in prostate cancer patients by facilitating the outgrowth of macroscopic tumours in the bone. +other 31738400 hsa-mir-1182 Colorectal Neoplasms circFMN2 is a central component linking circRNAs to progression of CRC via an miR-1182/hTERT axis. +genetics_overexpression_suppress 31737949 hsa-mir-144 Neuralgia Furthermore, overexpression of RASA1 reversed the inhibitory effect of miR-144 on neuropathic pain. +other 31737900 hsa-mir-877 Uterine Cervical Neoplasms Our findings clarified that DSCAM-AS1 played as an oncogenic lncRNA by targeting miR-877-5p/ATXN7L3 axis to promote CC progression +other 31737898 hsa-mir-15a Cataract However, the mechanism of microRNA-15a in the genesis of cataract remains barely known. We therefore aimed to investigate the role of microRNA-15a in the cataract. +other 31737678 hsa-mir-552 rectum adenocarcinoma 3 DEMIs (miR-490-3p, miR-133a-3p, and miR-552-3p) and 281 target genes were identified, and the 3 DEMIs showed high diagnostic value in READ and moderate diagnostic value in ESCA, GAC, and COAD. +other 31737678 hsa-mir-552 gastric adenocarcinoma 3 DEMIs (miR-490-3p, miR-133a-3p, and miR-552-3p) and 281 target genes were identified, and the 3 DEMIs showed high diagnostic value in READ and moderate diagnostic value in ESCA, GAC, and COAD. +other 31737678 hsa-mir-133a gastric adenocarcinoma 3 DEMIs (miR-490-3p, miR-133a-3p, and miR-552-3p) and 281 target genes were identified, and the 3 DEMIs showed high diagnostic value in READ and moderate diagnostic value in ESCA, GAC, and COAD. +other 31737678 hsa-mir-490 Colonic Neoplasms 3 DEMIs (miR-490-3p, miR-133a-3p, and miR-552-3p) and 281 target genes were identified, and the 3 DEMIs showed high diagnostic value in READ and moderate diagnostic value in ESCA, GAC, and COAD. +other 31737678 hsa-mir-490 rectum adenocarcinoma 3 DEMIs (miR-490-3p, miR-133a-3p, and miR-552-3p) and 281 target genes were identified, and the 3 DEMIs showed high diagnostic value in READ and moderate diagnostic value in ESCA, GAC, and COAD. +other 31737678 hsa-mir-490 esophageal carcinoma 3 DEMIs (miR-490-3p, miR-133a-3p, and miR-552-3p) and 281 target genes were identified, and the 3 DEMIs showed high diagnostic value in READ and moderate diagnostic value in ESCA, GAC, and COAD. +other 31737678 hsa-mir-490 gastric adenocarcinoma 3 DEMIs (miR-490-3p, miR-133a-3p, and miR-552-3p) and 281 target genes were identified, and the 3 DEMIs showed high diagnostic value in READ and moderate diagnostic value in ESCA, GAC, and COAD. +other 31737678 hsa-mir-133a rectum adenocarcinoma 3 DEMIs (miR-490-3p, miR-133a-3p, and miR-552-3p) and 281 target genes were identified, and the 3 DEMIs showed high diagnostic value in READ and moderate diagnostic value in ESCA, GAC, and COAD. +genetics_GWAS 31737664 hsa-mir-555 Precursor Cell Lymphoblastic Leukemia-Lymphoma Methods Polymorphisms of rs4846049 (miR-555 binding) were assessed by PCR amplification and direct sequencing in 110 ALL patients and 105 healthy controls. +lncRNA target 31737629 hsa-mir-29b Rotator Cuff Injuries VEGFA is the target of miR-29b in the vascular endothelium of individuals with DM. +transcription factor target 31737624 hsa-mir-384 Encephalomyelitis, Autoimmune, Experimental We previously showed that the dysregulation of miR-384 resulted in a T helper cell 17 (Th17) imbalance and contributed to the pathogenesis of experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. +epigenetics 31737624 hsa-mir-384 Nephritis, Interstitial These results indicate that STAT3, rather than DNA methylation, contributes to the regulation of miR-384 during Th17 polarization. +transcription factor target 31737624 hsa-mir-384 Multiple Sclerosis We previously showed that the dysregulation of miR-384 resulted in a T helper cell 17 (Th17) imbalance and contributed to the pathogenesis of experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. +lncRNA target 31737623 hsa-mir-144 Cardiomyopathies 3p-mediated-PTEN regulation might be a novel therapeutic target for cardiac fibrosis after MI. +lncRNA target 31737623 hsa-mir-144 Myocardial Infarction 3p-mediated-PTEN regulation might be a novel therapeutic target for cardiac fibrosis after MI. +other 31737436 hsa-mir-211 Uveal melanoma Importantly, miR-211 was able to accurately distinguish metastatic disease from localized uveal melanoma (P < 0.0001; area under the curve = 0.96). +other 31737436 hsa-mir-145 Uveal melanoma RESULTS: A panel of six miRNAs (miR-16, miR-145, miR-146a, miR-204, miR-211, and miR3p) showed significant differences between participants with uveal nevi compared with patients with localized and metastatic uveal melanoma. +other 31737436 hsa-mir-204 Uveal melanoma RESULTS: A panel of six miRNAs (miR-16, miR-145, miR-146a, miR-204, miR-211, and miR3p) showed significant differences between participants with uveal nevi compared with patients with localized and metastatic uveal melanoma. +other 31737436 hsa-mir-146a Uveal melanoma RESULTS: A panel of six miRNAs (miR-16, miR-145, miR-146a, miR-204, miR-211, and miR3p) showed significant differences between participants with uveal nevi compared with patients with localized and metastatic uveal melanoma. +other 31737436 hsa-mir-16 Uveal melanoma RESULTS: A panel of six miRNAs (miR-16, miR-145, miR-146a, miR-204, miR-211, and miR3p) showed significant differences between participants with uveal nevi compared with patients with localized and metastatic uveal melanoma. +other 31737319 hsa-mir-223 Atrial Fibrillation 5p is independently in correlation with AF. +other 31737319 hsa-mir-483 Atrial Fibrillation 5p is independently in correlation with AF. +other 31737319 hsa-mir-142 Atrial Fibrillation 5p is independently in correlation with AF. +other 31737212 hsa-mir-217 late onset Parkinson's disease 5p/SIRT1 axis was involved in the progression of PD by regulating the inflammatory response and the induction of oxidative stress and neuronal apoptosis. +other 31737212 hsa-mir-138 late onset Parkinson's disease 5p/SIRT1 axis was involved in the progression of PD by regulating the inflammatory response and the induction of oxidative stress and neuronal apoptosis. +lncRNA target 31737211 hsa-mir-124 Multiple Myeloma In this study, a novel established regulatory manner of LINC01234/miR3p/GRB2 axis was systematically studied, which may hold promise as a promising target for MM treatment. +genetics_overexpression_promote 31737199 hsa-mir-625 Carcinoma, Renal Cell Using in vitro functional assays, we found that overexpression of miR +lncRNA target 31737190 hsa-mir-125a Glioma In vivo assays also indicated that lncRNA HOXA11-AS inhibitor could inhibit glioma growth in vivo by regulating the expression of miR-125a. +lncRNA target 31737186 hsa-mir-612 Squamous Cell Carcinoma of Head and Neck In conclusion, our findings clarified the biologic significance of LINC00460/miR-612/AKT2 axis in HNSCC progression and provided novel evidence that LINC00460 may be a new potential therapeutic target for HNSCC. +other 31737170 hsa-mir-34a Hyperlipidemias This is the first study to comprehensively identify the lncRNA expression profiling of HG/PA-treated INS-1 beta cells and to demonstrate that LEGLTBC functions as a competing endogenous RNA and regulates miR-34a/SIRT1-mediated oxidative stress and apoptosis in INS-1 cells undergoing glucolipotoxicity. +other 31737116 hsa-mir-584 Carcinoma, Non-Small-Cell Lung Moreover, we found that the prognostic function of the eight miRNAs (miR-375, miR-148a, miR-29b-1 and miR-584 for LUAD; miR-4746, miR-326, miR-93 and miR-671 for LUSC). +other 31737116 hsa-mir-148a Carcinoma, Non-Small-Cell Lung Moreover, we found that the prognostic function of the eight miRNAs (miR-375, miR-148a, miR-29b-1 and miR-584 for LUAD; miR-4746, miR-326, miR-93 and miR-671 for LUSC). +other 31737116 hsa-mir-671 Carcinoma, Non-Small-Cell Lung Moreover, we found that the prognostic function of the eight miRNAs (miR-375, miR-148a, miR-29b-1 and miR-584 for LUAD; miR-4746, miR-326, miR-93 and miR-671 for LUSC). +other 31737116 hsa-mir-4746 Carcinoma, Non-Small-Cell Lung Moreover, we found that the prognostic function of the eight miRNAs (miR-375, miR-148a, miR-29b-1 and miR-584 for LUAD; miR-4746, miR-326, miR-93 and miR-671 for LUSC). +other 31737116 hsa-mir-29b-1 Carcinoma, Non-Small-Cell Lung Moreover, we found that the prognostic function of the eight miRNAs (miR-375, miR-148a, miR-29b-1 and miR-584 for LUAD; miR-4746, miR-326, miR-93 and miR-671 for LUSC). +other 31737116 hsa-mir-93 Carcinoma, Non-Small-Cell Lung Moreover, we found that the prognostic function of the eight miRNAs (miR-375, miR-148a, miR-29b-1 and miR-584 for LUAD; miR-4746, miR-326, miR-93 and miR-671 for LUSC). +other 31737116 hsa-mir-326 Carcinoma, Non-Small-Cell Lung Moreover, we found that the prognostic function of the eight miRNAs (miR-375, miR-148a, miR-29b-1 and miR-584 for LUAD; miR-4746, miR-326, miR-93 and miR-671 for LUSC). +other 31737116 hsa-mir-375 Carcinoma, Non-Small-Cell Lung Moreover, we found that the prognostic function of the eight miRNAs (miR-375, miR-148a, miR-29b-1 and miR-584 for LUAD; miR-4746, miR-326, miR-93 and miR-671 for LUSC). +transcription factor target 31736940 hsa-mir-155 Inflammation Thus, our novel results indicate that targeting miR-155 might be useful to inhibit exaggerated NET generation in inflammatory diseases. +other 31736422 hsa-mir-133a Prostatic Neoplasms MiR-133a-5p expression was significantly downregulated in prostate cancer +other 31736412 hsa-mir-338 Small Cell Lung Carcinoma Circ_0000003 promotes the proliferation and metastasis of NSCLC cells via modulating miR-338-3p/IRS2 axis. +other 31736268 hsa-mir-6882 Breast Neoplasms SPRY4-IT1 promotes proliferation and stemness of breast cancer cells as well as renewal ability and stemness maintenance of BCSCs by increasing the expression of TCF7L2 through targeting miR-6882-3p. +other 31736157 hsa-mir-93 Stomach Neoplasms matrine affected the progression of gastric cancer by inhibiting the function of gastric cancer cells through the possible mechanism of inhibiting miR-93-5p expression to increase the expression level of the downstream target gene AHNAK. +circRNA target 31736156 hsa-mir-599 Esophageal Neoplasms Enabled homolog (ENAH), which exhibited high expression in EC cells, was confirmed to be a downstream target gene of miR-599. +other 31736153 hsa-mir-6076 Endometrial Neoplasms our research was the first endeavor to study the underlying mechanism of CHL1-AS1 in EC and confirmed that CHL1-AS1 regulated EC progression via targeting the miR-6076/CHL1 axis +other 31736114 hsa-let-7b Atherosclerosis These results together suggest the potential of regulating the let-7b expression and endothelial apoptosis against development and progression of atherosclerosis. +other 31736084 hsa-mir-96 Triple Negative Breast Neoplasms a novel link between BRCA1 status and miRNA expression level was identified through miR-96 and miR-10b that were very important discriminators between TNBC with mutated BRCA1 and TNBC with wild type BRCA1. +other 31736084 hsa-mir-10b Triple Negative Breast Neoplasms a novel link between BRCA1 status and miRNA expression level was identified through miR-96 and miR-10b that were very important discriminators between TNBC with mutated BRCA1 and TNBC with wild type BRCA1. +genetics_overexpression_promote 31736006 hsa-mir-15a Peripheral Nerve Injuries We further demonstrated that miR-15a overexpression downregulated the level of AKT3 in primary rat microglia and rat CCI model. +genetics_overexpression_promote 31736006 hsa-mir-15a Neuralgia We further demonstrated that miR-15a overexpression downregulated the level of AKT3 in primary rat microglia and rat CCI model. +other 31735958 hsa-mir-132 Periodontitis TUG1 had a decreased expression in both periodontal ligament (PDL) tissues with periodontitis and PDLCs under a LPS-induced inflammatory condition, and TUG1 expression was negatively correlated with miR-132 expression in periodontitis-affected PDL tissues. +other 31735661 hsa-mir-27a Inflammation CONCLUSION: LPS triggered adverse inflammation response by elevating the biogenesis of circAtp9b which caused a repressive role in miR-27a expression. +other 31735555 hsa-mir-216b Nephrocalcinosis We determined that H19 might serve as a facilitator in the process of CaOx nephrocalcinosis-induced oxidative stress and renal tubular epithelial cell injury, and we revealed that the interaction between H19 and miR-216b could exert its effect via the HMGB1/TLR4/NF-kappaB pathway. +transcription factor target 31735332 hsa-mir-24 Reperfusion Injury, Hepatic Ischemia This study suggests that miR3p may ameliorate inflammatory response and cellular apoptosis in hepatic I/R process by targeting STING, which might be a potential therapeutic target for preventing liver I/R development and progression. +other 31735321 hsa-mir-107 Carcinoma, Non-Small-Cell Lung Our data suggested that miR-107 could inhibit the progression of NSCLC by targeting TGFbetaR2. +other 31735218 hsa-let-7a Breast Neoplasms it can also be used to determine let-7a levels at single-cell resolution and evaluate the drug efficacy of let-7a expression among various molecular types of breast cancer cell lines. +other 31735077 hsa-mir-140 Osteoarthritis inhibition of miR-140-5p significantly reversed the inhibitory effect of silencing LINC01534 on abnormal matrix degradation in the IL-1beta-induced chondrocyte model of OA. +other 31734880 hsa-mir-155 Alzheimer Disease In human AD brain, changes of microRNA pattern (miRNA-9, miRNA-34a, miRNA-146a and miRNA-155) seem to be responsible for decrease in Sirt1 expression. +other 31734880 hsa-mir-146a Alzheimer Disease In human AD brain, changes of microRNA pattern (miRNA-9, miRNA-34a, miRNA-146a and miRNA-155) seem to be responsible for decrease in Sirt1 expression. +other 31734880 hsa-mir-34a Alzheimer Disease In human AD brain, changes of microRNA pattern (miRNA-9, miRNA-34a, miRNA-146a and miRNA-155) seem to be responsible for decrease in Sirt1 expression. +other 31734880 hsa-mir-9 Alzheimer Disease In human AD brain, changes of microRNA pattern (miRNA-9, miRNA-34a, miRNA-146a and miRNA-155) seem to be responsible for decrease in Sirt1 expression. +other 31734650 hsa-mir-96 Glioma We also observed down-regulation of microRNA miR-206, miR-96, and miR-19a, which have specific binding sites in mRNA EDN1, EDNRA, and EDNRB, correspondingly +other 31734650 hsa-mir-19a Glioma We also observed down-regulation of microRNA miR-206, miR-96, and miR-19a, which have specific binding sites in mRNA EDN1, EDNRA, and EDNRB, correspondingly +other 31734650 hsa-mir-19 Glioma We also observed down-regulation of microRNA miR-206, miR-96, and miR-19a, which have specific binding sites in mRNA EDN1, EDNRA, and EDNRB, correspondingly +other 31734650 hsa-mir-206 Glioma We also observed down-regulation of microRNA miR-206, miR-96, and miR-19a, which have specific binding sites in mRNA EDN1, EDNRA, and EDNRB, correspondingly +other 31734579 hsa-mir-410 Urinary Bladder Neoplasms we implicated miR-410 was dramatically restrained in bladder cancer cells. +epigenetics 31734560 hsa-mir-495 Acute Lung Injury Taken together, the data in our study demonstrated that methylation of the miR-495 promoter could downregulate miR-495, whose elevation could attenuate the activation of the NLRP3 inflammasome to protect against ALI, which provides novel therapeutic targets for ALI treatment. +genetics_overexpression_promote 31734557 hsa-mir-133 familial febrile seizures 1 The inhibition of XIST and overexpression of miR-133a also promote cell viability of H/R cells. +genetics_overexpression_promote 31734557 hsa-mir-133a familial febrile seizures 1 The inhibition of XIST and overexpression of miR-133a also promote cell viability of H/R cells. +genetics_overexpression_suppress 31734320 hsa-mir-181b Pulmonary Arterial Hypertension Our data showed that miR-181b was down-expressed in PAH, and its overexpression attenuated the hemodynamics, pulmonary vascular hypertrophy, right ventricular remodeling and EndMT process in MCT-induced PAH rats. +transcription factor target 31734271 hsa-mir-29b Brain Edema The dysregulation of miR-29b after 1,2-DCE exposure can aggravate brain edema by directly suppressing the expression of AQP4. +other 31734182 hsa-mir-675 Colorectal Neoplasms Expression of miR675-5p or its precursor RNA, H19, correlated with expression of cyclooxygenase-1 and cyclooxygenase-2 and shorter survival times of patients with CRC +tissue_expression_down 31734055 hsa-mir-452 Stomach Neoplasms down-regulation of miR-452 expression significantly inhibited the malignant biological behavior of gastric cancer cells +other 31733831 hsa-mir-200a Asthma Collectively, it was demonstrated that the effect of IRN on asthma relied on the up-regulation of miR-200a, which then deactivated FOXC1/NF-kappaB pathway. +other 31733640 hsa-mir-29a Uterine Cervical Neoplasms miR21 and miR-29a diagnostic usefulness for HPV infection and Cervical Cancer (CC) detection +other 31733640 hsa-mir-21 Uterine Cervical Neoplasms miR21 and miR-29a diagnostic usefulness for HPV infection and Cervical Cancer (CC) detection +other 31733638 hsa-mir-146a Diabetes Mellitus, Type 2 In contrast, swimming exercise resulted in a significant decrease in expression levels of miR-146a, NF-small ka, CyrillicB and inflammatory cytokines and a significant increase in expression levels of TRAF6 and IRAK1 in the exercise-diabetic group compared to the diabetic group. +other 31733638 hsa-mir-146 Diabetes Mellitus, Type 2 In contrast, swimming exercise resulted in a significant decrease in expression levels of miR-146a, NF-small ka, CyrillicB and inflammatory cytokines and a significant increase in expression levels of TRAF6 and IRAK1 in the exercise-diabetic group compared to the diabetic group. +lncRNA target 31733592 hsa-mir-124 Cystic Fibrosis This was demonstrated using the argininocalix[4]arene 1 in miRNA therapeutic approaches performed on three well-described experimental model systems: (1) the induction of apoptosis by antimiR-221 in glioma U251 cells; (2) the induction of apoptosis by premiR-124 in U251 cells; and (3) the inhibition of pro-inflammatory IL-8 and IL-6 genes in cystic fibrosis IB3-1 cells. +lncRNA target 31733592 hsa-mir-124 high grade glioma This was demonstrated using the argininocalix[4]arene 1 in miRNA therapeutic approaches performed on three well-described experimental model systems: (1) the induction of apoptosis by antimiR-221 in glioma U251 cells; (2) the induction of apoptosis by premiR-124 in U251 cells; and (3) the inhibition of pro-inflammatory IL-8 and IL-6 genes in cystic fibrosis IB3-1 cells. +transcription factor target 31733152 hsa-mir-24 Acquired Immunodeficiency Syndrome infected CD4+ T cells that inhibited CD34+ haematopoietic progenitor stem cell differentiation into myeloid and erythroid colonies in vitro. +transcription factor target 31733152 hsa-mir-15a Acquired Immunodeficiency Syndrome infected CD4+ T cells that inhibited CD34+ haematopoietic progenitor stem cell differentiation into myeloid and erythroid colonies in vitro. +lncRNA target 31733099 hsa-mir-130a Polycystic Ovary Syndrome LncRNA HOTAIR up-regulates the expression of IGF1 and aggravates the endocrine disorders and granulosa cell apoptosis through competitive binding to miR-130a in rat models of PCOS. +other 31733095 hsa-mir-29a Prostatic Neoplasms circFOXO3 acts as a miR-29a-3p sponge to exhibit oncogenic activity that affects the cell cycle and cell apoptosis in PCa through transcriptional up-regulation of SLC25A15. +lncRNA target 31733028 hsa-mir-1275 Esophageal Neoplasms Collectively, our findings suggested that miR-1275 suppressed EMT to encourage radiosensitivity in EC cells via targeting WNT1-activated Wnt/beta-catenin signalling, providing a new therapeutic outlet for overcoming radioresistance of patients with EC. +tissue_expression_down 31732974 hsa-mir-28 Pancreatic Neoplasms miR-28-5p overexpression inhibited cell proliferation and migration in PC. +other 31732967 hsa-mir-29c Parkinson Disease in SH-SY5Y cell models of PD, we also found that miR-29c inhibited inflammatory cytokine production, reduced apoptotic rate and suppressed pro-apoptotic regulator activity. +other 31732956 hsa-mir-140 Osteoporosis miR-140-3p was highly expressed; meanwhile, MCF2L was lowly expressed in osteoporosis patients. +other 31732917 hsa-mir-208a Heart Defects, Congenital MiRNA-208a may serve as a biomarker for the prediction of patients who are at risk to develop complications following surgery for the repair of congenital heart defects. +tissue_expression_up 31732824 hsa-mir-34a Diabetes Mellitus, Type 2 MiR-34a was significantly upregulated, whereas miR-126 was nonsignificantly reduced in T2D patients as compared to controls +tissue_expression_down 31732382 hsa-mir-455 Carcinoma, Hepatocellular we found that miR-455-5p expression was significantly decreased in both HCC patient tumor tissues and cell lines +other 31732359 hsa-mir-4486 Pulmonary Disease, Chronic Obstructive Differential expression of miR-619-5p and miR-4486 in COPDe patients were validated in the complete cohort +other 31732359 hsa-mir-619 Pulmonary Disease, Chronic Obstructive Differential expression of miR-619-5p and miR-4486 in COPDe patients were validated in the complete cohort +other 31732311 hsa-mir-335 Nasopharyngeal Carcinoma Gene methylation contributes the expression of miR-335 in nasopharyngeal carcinoma. +other 31732298 hsa-mir-24-2 Liver Neoplasms These results provided a valuable theoretical basis for the discovery of liver cancer therapeutic targets and diagnosis markers based on miR24-2. +other 31732152 hsa-mir-145 Cicatrix, Hypertrophic miR-145-5p arrests the development of fibrogenesis and decreases HS formation +tissue_expression_up 31731799 hsa-mir-23a Macular Degeneration AMD was an independent factor associated with lower levels of angiogenin (beta = -0.29, p < 0.001), endostatin (beta = -0.18, p < 0.001), FGF-basic (beta = -0.18, p < 0.001), PlGF (beta = -0.24, p < 0.001), miRNA-21-3p (beta = -0.13, p = 0.01) and miRNA-155-5p (beta = -0.16, p = 0.002); and with higher levels of FGF-acidic (beta = 0.11, p = 0.03), miRNA-23a-3p (beta = 0.17, p < 0.001), miRNA-126-5p (beta = 0.13, p = 0.009), miRNA-16-5p (beta = 0.40, p < 0.001), miRNA-17-3p (beta = 0.13, p = 0.01), miRNA-17-5p (beta = 0.17, p < 0.001), miRNA-223-3p (beta = 0.15, p = 0.004), and miRNA-93 (beta = 0.11, p = 0.04). +tissue_expression_up 31731799 hsa-mir-223 Macular Degeneration AMD was an independent factor associated with lower levels of angiogenin (beta = -0.29, p < 0.001), endostatin (beta = -0.18, p < 0.001), FGF-basic (beta = -0.18, p < 0.001), PlGF (beta = -0.24, p < 0.001), miRNA-21-3p (beta = -0.13, p = 0.01) and miRNA-155-5p (beta = -0.16, p = 0.002); and with higher levels of FGF-acidic (beta = 0.11, p = 0.03), miRNA-23a-3p (beta = 0.17, p < 0.001), miRNA-126-5p (beta = 0.13, p = 0.009), miRNA-16-5p (beta = 0.40, p < 0.001), miRNA-17-3p (beta = 0.13, p = 0.01), miRNA-17-5p (beta = 0.17, p < 0.001), miRNA-223-3p (beta = 0.15, p = 0.004), and miRNA-93 (beta = 0.11, p = 0.04). +tissue_expression_up 31731799 hsa-mir-93 Macular Degeneration AMD was an independent factor associated with lower levels of angiogenin (beta = -0.29, p < 0.001), endostatin (beta = -0.18, p < 0.001), FGF-basic (beta = -0.18, p < 0.001), PlGF (beta = -0.24, p < 0.001), miRNA-21-3p (beta = -0.13, p = 0.01) and miRNA-155-5p (beta = -0.16, p = 0.002); and with higher levels of FGF-acidic (beta = 0.11, p = 0.03), miRNA-23a-3p (beta = 0.17, p < 0.001), miRNA-126-5p (beta = 0.13, p = 0.009), miRNA-16-5p (beta = 0.40, p < 0.001), miRNA-17-3p (beta = 0.13, p = 0.01), miRNA-17-5p (beta = 0.17, p < 0.001), miRNA-223-3p (beta = 0.15, p = 0.004), and miRNA-93 (beta = 0.11, p = 0.04). +tissue_expression_down 31731799 hsa-mir-21 Macular Degeneration AMD was an independent factor associated with lower levels of angiogenin (beta = -0.29, p < 0.001), endostatin (beta = -0.18, p < 0.001), FGF-basic (beta = -0.18, p < 0.001), PlGF (beta = -0.24, p < 0.001), miRNA-21-3p (beta = -0.13, p = 0.01) and miRNA-155-5p (beta = -0.16, p = 0.002); and with higher levels of FGF-acidic (beta = 0.11, p = 0.03), miRNA-23a-3p (beta = 0.17, p < 0.001), miRNA-126-5p (beta = 0.13, p = 0.009), miRNA-16-5p (beta = 0.40, p < 0.001), miRNA-17-3p (beta = 0.13, p = 0.01), miRNA-17-5p (beta = 0.17, p < 0.001), miRNA-223-3p (beta = 0.15, p = 0.004), and miRNA-93 (beta = 0.11, p = 0.04). +tissue_expression_up 31731799 hsa-mir-16 Macular Degeneration AMD was an independent factor associated with lower levels of angiogenin (beta = -0.29, p < 0.001), endostatin (beta = -0.18, p < 0.001), FGF-basic (beta = -0.18, p < 0.001), PlGF (beta = -0.24, p < 0.001), miRNA-21-3p (beta = -0.13, p = 0.01) and miRNA-155-5p (beta = -0.16, p = 0.002); and with higher levels of FGF-acidic (beta = 0.11, p = 0.03), miRNA-23a-3p (beta = 0.17, p < 0.001), miRNA-126-5p (beta = 0.13, p = 0.009), miRNA-16-5p (beta = 0.40, p < 0.001), miRNA-17-3p (beta = 0.13, p = 0.01), miRNA-17-5p (beta = 0.17, p < 0.001), miRNA-223-3p (beta = 0.15, p = 0.004), and miRNA-93 (beta = 0.11, p = 0.04). +tissue_expression_up 31731799 hsa-mir-17 Macular Degeneration AMD was an independent factor associated with lower levels of angiogenin (beta = -0.29, p < 0.001), endostatin (beta = -0.18, p < 0.001), FGF-basic (beta = -0.18, p < 0.001), PlGF (beta = -0.24, p < 0.001), miRNA-21-3p (beta = -0.13, p = 0.01) and miRNA-155-5p (beta = -0.16, p = 0.002); and with higher levels of FGF-acidic (beta = 0.11, p = 0.03), miRNA-23a-3p (beta = 0.17, p < 0.001), miRNA-126-5p (beta = 0.13, p = 0.009), miRNA-16-5p (beta = 0.40, p < 0.001), miRNA-17-3p (beta = 0.13, p = 0.01), miRNA-17-5p (beta = 0.17, p < 0.001), miRNA-223-3p (beta = 0.15, p = 0.004), and miRNA-93 (beta = 0.11, p = 0.04). +tissue_expression_down 31731799 hsa-mir-155 Macular Degeneration AMD was an independent factor associated with lower levels of angiogenin (beta = -0.29, p < 0.001), endostatin (beta = -0.18, p < 0.001), FGF-basic (beta = -0.18, p < 0.001), PlGF (beta = -0.24, p < 0.001), miRNA-21-3p (beta = -0.13, p = 0.01) and miRNA-155-5p (beta = -0.16, p = 0.002); and with higher levels of FGF-acidic (beta = 0.11, p = 0.03), miRNA-23a-3p (beta = 0.17, p < 0.001), miRNA-126-5p (beta = 0.13, p = 0.009), miRNA-16-5p (beta = 0.40, p < 0.001), miRNA-17-3p (beta = 0.13, p = 0.01), miRNA-17-5p (beta = 0.17, p < 0.001), miRNA-223-3p (beta = 0.15, p = 0.004), and miRNA-93 (beta = 0.11, p = 0.04). +tissue_expression_up 31731799 hsa-mir-126 Macular Degeneration AMD was an independent factor associated with lower levels of angiogenin (beta = -0.29, p < 0.001), endostatin (beta = -0.18, p < 0.001), FGF-basic (beta = -0.18, p < 0.001), PlGF (beta = -0.24, p < 0.001), miRNA-21-3p (beta = -0.13, p = 0.01) and miRNA-155-5p (beta = -0.16, p = 0.002); and with higher levels of FGF-acidic (beta = 0.11, p = 0.03), miRNA-23a-3p (beta = 0.17, p < 0.001), miRNA-126-5p (beta = 0.13, p = 0.009), miRNA-16-5p (beta = 0.40, p < 0.001), miRNA-17-3p (beta = 0.13, p = 0.01), miRNA-17-5p (beta = 0.17, p < 0.001), miRNA-223-3p (beta = 0.15, p = 0.004), and miRNA-93 (beta = 0.11, p = 0.04). +transcription factor target 31731750 hsa-mir-29a Rotator Cuff Injuries This study also highlights the remedial potential of miR-29a precursor for alleviating the shoulder disorder. +other 31731456 hsa-mir-19b Central Nervous System Neoplasms In 131 patients with CNS DLBCL and with non-malignant brain lesions (n-ML), miR-21, miR-19b and miR-92a, miR-155, miR-196b, miR-let-7b, miR-125b, and miR-9 were examined by RT-qPCR in brain biopsy samples (formalin-fixed paraffin-embedded tissues, FFPET; CNS DLBCL, n = 52; n-ML, n = 42) and cerebrospinal fluid samples (CSF; CNS DLBCL, n = 30; n-ML, n = 23) taken for routine diagnosis. +genetics_overexpression_suppress 31731456 hsa-mir-155 Central Nervous System Neoplasms In FFPETs, miR-155 and miR-196b were significantly overexpressed and miR-let-7b, miR-125b, and miR-9 were downregulated in PCNSL as compared to n-ML. +other 31731456 hsa-mir-21 Central Nervous System Neoplasms In 131 patients with CNS DLBCL and with non-malignant brain lesions (n-ML), miR-21, miR-19b and miR-92a, miR-155, miR-196b, miR-let-7b, miR-125b, and miR-9 were examined by RT-qPCR in brain biopsy samples (formalin-fixed paraffin-embedded tissues, FFPET; CNS DLBCL, n = 52; n-ML, n = 42) and cerebrospinal fluid samples (CSF; CNS DLBCL, n = 30; n-ML, n = 23) taken for routine diagnosis. +genetics_overexpression_suppress 31731456 hsa-let-7b Central Nervous System Neoplasms In FFPETs, miR-155 and miR-196b were significantly overexpressed and miR-let-7b, miR-125b, and miR-9 were downregulated in PCNSL as compared to n-ML. +other 31731456 hsa-mir-196b Central Nervous System Neoplasms In 131 patients with CNS DLBCL and with non-malignant brain lesions (n-ML), miR-21, miR-19b and miR-92a, miR-155, miR-196b, miR-let-7b, miR-125b, and miR-9 were examined by RT-qPCR in brain biopsy samples (formalin-fixed paraffin-embedded tissues, FFPET; CNS DLBCL, n = 52; n-ML, n = 42) and cerebrospinal fluid samples (CSF; CNS DLBCL, n = 30; n-ML, n = 23) taken for routine diagnosis. +other 31731456 hsa-mir-92a Central Nervous System Neoplasms In 131 patients with CNS DLBCL and with non-malignant brain lesions (n-ML), miR-21, miR-19b and miR-92a, miR-155, miR-196b, miR-let-7b, miR-125b, and miR-9 were examined by RT-qPCR in brain biopsy samples (formalin-fixed paraffin-embedded tissues, FFPET; CNS DLBCL, n = 52; n-ML, n = 42) and cerebrospinal fluid samples (CSF; CNS DLBCL, n = 30; n-ML, n = 23) taken for routine diagnosis. +other 31731456 hsa-mir-125b Central Nervous System Neoplasms In 131 patients with CNS DLBCL and with non-malignant brain lesions (n-ML), miR-21, miR-19b and miR-92a, miR-155, miR-196b, miR-let-7b, miR-125b, and miR-9 were examined by RT-qPCR in brain biopsy samples (formalin-fixed paraffin-embedded tissues, FFPET; CNS DLBCL, n = 52; n-ML, n = 42) and cerebrospinal fluid samples (CSF; CNS DLBCL, n = 30; n-ML, n = 23) taken for routine diagnosis. +other 31731456 hsa-mir-9 Central Nervous System Neoplasms In 131 patients with CNS DLBCL and with non-malignant brain lesions (n-ML), miR-21, miR-19b and miR-92a, miR-155, miR-196b, miR-let-7b, miR-125b, and miR-9 were examined by RT-qPCR in brain biopsy samples (formalin-fixed paraffin-embedded tissues, FFPET; CNS DLBCL, n = 52; n-ML, n = 42) and cerebrospinal fluid samples (CSF; CNS DLBCL, n = 30; n-ML, n = 23) taken for routine diagnosis. +circulation_biomarker_diagnosis_ns 31731380 hsa-mir-29c Urinary Bladder Neoplasms The present study identified 7 miRNAs were up-regulated in bladder serum cancer samples compared to normal samples, including hsa-miR-185-5p, hsa-miR-663a, hsa-miR-30c-5p, hsa-miR-3648, hsa-miR-1270, hsa-miR-200c-3p, and hsa-miR-29c-5p. +circulation_biomarker_diagnosis_ns 31731380 hsa-mir-185 Urinary Bladder Neoplasms The present study identified 7 miRNAs were up-regulated in bladder serum cancer samples compared to normal samples, including hsa-miR-185-5p, hsa-miR-663a, hsa-miR-30c-5p, hsa-miR-3648, hsa-miR-1270, hsa-miR-200c-3p, and hsa-miR-29c-5p. +circulation_biomarker_diagnosis_ns 31731380 hsa-mir-200c Urinary Bladder Neoplasms The present study identified 7 miRNAs were up-regulated in bladder serum cancer samples compared to normal samples, including hsa-miR-185-5p, hsa-miR-663a, hsa-miR-30c-5p, hsa-miR-3648, hsa-miR-1270, hsa-miR-200c-3p, and hsa-miR-29c-5p. +circulation_biomarker_diagnosis_ns 31731380 hsa-mir-663a Urinary Bladder Neoplasms The present study identified 7 miRNAs were up-regulated in bladder serum cancer samples compared to normal samples, including hsa-miR-185-5p, hsa-miR-663a, hsa-miR-30c-5p, hsa-miR-3648, hsa-miR-1270, hsa-miR-200c-3p, and hsa-miR-29c-5p. +circulation_biomarker_diagnosis_ns 31731380 hsa-mir-1270 Urinary Bladder Neoplasms The present study identified 7 miRNAs were up-regulated in bladder serum cancer samples compared to normal samples, including hsa-miR-185-5p, hsa-miR-663a, hsa-miR-30c-5p, hsa-miR-3648, hsa-miR-1270, hsa-miR-200c-3p, and hsa-miR-29c-5p. +circulation_biomarker_diagnosis_ns 31731380 hsa-mir-648 Urinary Bladder Neoplasms The present study identified 7 miRNAs were up-regulated in bladder serum cancer samples compared to normal samples, including hsa-miR-185-5p, hsa-miR-663a, hsa-miR-30c-5p, hsa-miR-3648, hsa-miR-1270, hsa-miR-200c-3p, and hsa-miR-29c-5p. +circulation_biomarker_diagnosis_ns 31731194 hsa-mir-150 Colorectal Neoplasms a decreased miR-150 expression in colorectal cancer tissues and cells was observed. +other 31731191 hsa-mir-195 Carcinoma, Hepatocellular LINC00511 interacted with EYA1 promoted HCC development via mediating miR-195 +other 31731190 hsa-mir-7 Colorectal Neoplasms CASC21 functions as a ceRNA that plays an oncogenic role in the progression of colorectal cancer by regulating the miR-7-5p/YAP1 axis. +other 31731187 hsa-mir-98 Squamous Cell Carcinoma of Head and Neck MiR-98-5p was a target of HOXA11-AS, and its inhibitor could revert the inhibition effect of silenced-HOXA11-AS on the progression of OSCC +tissue_expression_down 31731055 hsa-mir-214 Multiple Myeloma miR-214 was obviously down-regulated in MM patients +other 31730913 hsa-mir-21 Glioblastoma Antisense miRNA oligonucleotides against miR-21 (AMO-21) have a therapeutic potential for treatment of glioblastoma. In addition, delivery of AMO-21 using T7-exo reduced the miR-21 level in the glioblastoma efficiently. +other 31730734 hsa-mir-1 Colitis resveratrol-mediated attenuation of colitis may be regulated by miR-31 through induction of Tregs and miR-31 may serve as a therapeutic target for human colitis. +other 31730714 hsa-mir-15a Kidney Neoplasms Increased miRNAs (miR-15a, miR-17, miR3p, miR-181a) were noted in common among AAs with breast, kidney, thyroid, or prostate carcinomas. +other 31730714 hsa-mir-181a Sveinsson Chorioretinal Atrophy Increased miRNAs (miR-15a, miR-17, miR3p, miR-181a) were noted in common among AAs with breast, kidney, thyroid, or prostate carcinomas. +other 31730714 hsa-mir-17 Sveinsson Chorioretinal Atrophy Increased miRNAs (miR-15a, miR-17, miR3p, miR-181a) were noted in common among AAs with breast, kidney, thyroid, or prostate carcinomas. +other 31730714 hsa-mir-181a Kidney Neoplasms Increased miRNAs (miR-15a, miR-17, miR3p, miR-181a) were noted in common among AAs with breast, kidney, thyroid, or prostate carcinomas. +other 31730714 hsa-mir-130 Sveinsson Chorioretinal Atrophy Increased miRNAs (miR-15a, miR-17, miR3p, miR-181a) were noted in common among AAs with breast, kidney, thyroid, or prostate carcinomas. +other 31730714 hsa-mir-15a Sveinsson Chorioretinal Atrophy Increased miRNAs (miR-15a, miR-17, miR3p, miR-181a) were noted in common among AAs with breast, kidney, thyroid, or prostate carcinomas. +other 31730714 hsa-mir-17 Kidney Neoplasms Increased miRNAs (miR-15a, miR-17, miR3p, miR-181a) were noted in common among AAs with breast, kidney, thyroid, or prostate carcinomas. +other 31730714 hsa-mir-130 Kidney Neoplasms Increased miRNAs (miR-15a, miR-17, miR3p, miR-181a) were noted in common among AAs with breast, kidney, thyroid, or prostate carcinomas. +exosome 31730486 hsa-mir-26a Femur Head Necrosis The biological effect of miR-26a-CD34(+)-Exos make them suitable for application in the prevention of GC-induced ONFH. +other 31730405 hsa-mir-15b Aortic Aneurysm, Abdominal hsa-miR-30a-GNG2 and hsa-miR-15b-ACSS2 interaction pairs may represent novel mechanisms for explaining the pathogenesis of AAA. +other 31730378 hsa-mir-17 Cardiomyopathies the autophagy happens to cardiocyte by upregulating the expression of miR-17-3p. +other 31730275 hsa-mir-485 Neurodegenerative Diseases Thus, altering miR3p and TRIP6 modulation may be one promising therapy for treating with neurodegenerative and neurogenesis diseases. +other 31730233 hsa-mir-200b Hypertension, Pulmonary This study confirmed the down-regulation of miR-200b in cor pulmonale. +circulation_biomarker_diagnosis_ns 31730174 hsa-mir-451a Polycystic Ovary Syndrome Girls with PCOS, compared with controls, had markedly reduced concentrations of circulating miR-451a, miR-652-3p, miR-106b-5p, and miR-206; +circulation_biomarker_diagnosis_ns 31730174 hsa-mir-106b Polycystic Ovary Syndrome Girls with PCOS, compared with controls, had markedly reduced concentrations of circulating miR-451a, miR-652-3p, miR-106b-5p, and miR-206; +circulation_biomarker_diagnosis_ns 31730174 hsa-mir-206 Polycystic Ovary Syndrome Girls with PCOS, compared with controls, had markedly reduced concentrations of circulating miR-451a, miR-652-3p, miR-106b-5p, and miR-206; +circulation_biomarker_diagnosis_ns 31730174 hsa-mir-652 Polycystic Ovary Syndrome Girls with PCOS, compared with controls, had markedly reduced concentrations of circulating miR-451a, miR-652-3p, miR-106b-5p, and miR-206; +other 31730013 hsa-mir-326 acute myocardial infarction Transplantation of miR-326-5p-overexpressing EPCs improved cardiac function for AMI therapy +other 31729887 hsa-mir-19a Carcinoma, Hepatocellular Hsa-mir-19a was identified as showed different effects in the three HCC differential regulation networks +other 31729834 hsa-mir-291a Osteoporosis miR-291a-3p plays an important role in preventing osteoporosis and may serve as a potential miRNA osteoporosis biomarker. +other 31729781 hsa-mir-195 Diabetic Cardiomyopathies In summary, our present study provides novel insights into the regulatory mechanism of miR5p/SGK1/Nedd4-2/hERG in rat cardiomyocytes under high-glucose stress, which may provide a novel idea for the development of diagnostic and therapeutic strategies for diabetic cardiomyopathy in the future. +other 31729781 hsa-mir-195 Diabetes Mellitus Based on the results of our previous study and the bioinformatics prediction, we identified miR5p/SGK1/Nedd4-2/hERG as the top-ranked signal pathway in diabetes cell model in vitro. +other 31729558 hsa-mir-135a Pancreatitis over-expression of FAM129A could strengthen the relief effect of miR-135a inhibitor in AP induced by cerulein. +other 31729531 hsa-mir-574 Colorectal Neoplasms miR-574-3p overexpression prohibited the activity of CCND2 in SW480 and HT29 cells. Silencing of CCND2 in SW480 and HT29 CRC cell lines leading to reduced cell proliferative and migrative rates, and enhanced apoptotic rate. +tissue_expression_up 31729423 hsa-mir-24 Colonic Neoplasms hsa-miR-324-5p was upregulated, while FGFR3, PLCB4, and IKBKB were downregulated in the tumor tissues as compared to that in the adjacent normal tissues. +other 31729147 hsa-mir-150 Wounds and Injuries Acute skin wounds treated with the top hit NP complexed with miRNA5p healed faster than wounds treated with scrambled miRNA. +other 31729134 hsa-mir-660 Breast Neoplasms the regulatory function of the circFBXL5/miR-660/SRSF6 pathway in breast cancer progression +circulation_biomarker_diagnosis_ns 31728904 hsa-mir-132 Metabolic Syndrome miRNAs hsa-miR-122, hsa-miR-130, and hsa-miR-132 were all significantly reduced whereas hsa-miR-375 was increased after gastric bypass surgery (p < 0.001 for all miRNAs) +circulation_biomarker_diagnosis_ns 31728904 hsa-mir-122 Metabolic Syndrome miRNAs hsa-miR-122, hsa-miR-130, and hsa-miR-132 were all significantly reduced whereas hsa-miR-375 was increased after gastric bypass surgery (p < 0.001 for all miRNAs) +circulation_biomarker_diagnosis_ns 31728904 hsa-mir-130 Metabolic Syndrome miRNAs hsa-miR-122, hsa-miR-130, and hsa-miR-132 were all significantly reduced whereas hsa-miR-375 was increased after gastric bypass surgery (p < 0.001 for all miRNAs) +circulation_biomarker_diagnosis_ns 31728904 hsa-mir-375 Metabolic Syndrome miRNAs hsa-miR-122, hsa-miR-130, and hsa-miR-132 were all significantly reduced whereas hsa-miR-375 was increased after gastric bypass surgery (p < 0.001 for all miRNAs) +exosome 31728833 hsa-mir-46146 Colorectal Neoplasms CONCLUSIONS: These results indicate that exosomal miR-46146 functions as a vital mediator of OX resistance by targeting PDCD10 and could be a potential target to re-sensitize CRC cell to OX. +other 31728150 hsa-mir-9 Colorectal Neoplasms miR-9-5p targeting of PAK4 could have therapeutic potential for CRC treatment. +other 31728016 hsa-mir-93 Small Cell Lung Carcinoma cESRP1 plays crucial a role in SCLC chemosensitivity by sponging miR-93-5p to inhibit the TGF-beta pathway +other 31727944 hsa-let-7b Leukemia, Myeloid, Acute MicroRNA let-7B, may account for the beneficial effects of pinometostat treatment in patients with MLL-r involving DOT1L. +other 31727683 hsa-mir-541 Carcinoma, Hepatocellular The expression of miR-541 was downregulated in human HCC tissues +other 31727503 hsa-mir-1304 Osteosarcoma circ_0102049 functions as a competing endogenous RNA (ceRNA) to competitively sponge miR-1304-5p to upregulate MDM2 expression at posttranscriptional level, thus mediating the cellular behaviors of OS cells. +tissue_expression_down 31727502 hsa-mir-129 Retinoblastoma miR-129-5p was down-regulated in RB cell lines. +tissue_expression_down 31727371 hsa-mir-485 Diabetic Nephropathies We found that miR-485 expression is significantly decreased in HG-stimulated HMCs +tissue_expression_up 31727100 hsa-mir-889 Osteoporosis miR-889 expression was upregulated in osteoporosis patients than healthy control +circulation_biomarker_diagnosis_ns 31727091 hsa-mir-128 Precursor Cell Lymphoblastic Leukemia-Lymphoma 3p in blood predict day 15 flow cytometry MRD results 7 days earlier. +circulation_biomarker_diagnosis_ns 31727091 hsa-mir-222 Precursor Cell Lymphoblastic Leukemia-Lymphoma 3p in blood predict day 15 flow cytometry MRD results 7 days earlier. +circulation_biomarker_diagnosis_up 31727077 hsa-mir-21 Multiple Sclerosis Levels of miR-21 and miR-146a/b in cell-free CSF may represent valuable biomarkers to identify patients with active MS lesions. +circulation_biomarker_diagnosis_up 31727077 hsa-mir-146a Multiple Sclerosis Levels of miR-21 and miR-146a/b in cell-free CSF may represent valuable biomarkers to identify patients with active MS lesions. +genetics_overexpression_promote 31727022 hsa-mir-124 Cleft Lip Overexpression of miR +circulation_biomarker_diagnosis_ns 31727002 hsa-mir-155 Lung Neoplasms The present meta-analysis demonstrated that miR-155 could be a potential biomarker for the detection of lung cancer but not an effective biomarker for predicting the outcomes of lung cancer. +target gene 31726456 hsa-mir-150 Intervertebral Disc Degeneration miR-150 may alleviate the degeneration of the intervertebral disc partially since it could restrict the NF-kappaB pathway by targeting P2X7, and thereby inhibiting IL-1beta-induced matrix catabolism, inflammatory responses and apoptosis of the nucleus pulposus cells. +genetics_knock down_suppress 31726387 hsa-mir-17 ankylosing spondylitis 1 On the other hand, AS patient-derived fibroblasts overexpressing miR +lncRNA target 31726371 hsa-mir-9 Liver Neoplasms our data demonstrated that HULC knockdown repressed GC progression at least partly by regulating miR-9-5p/MYH9 axis. +lncRNA target 31726370 hsa-mir-873 stomach carcinoma lncRNA TDRG1 regulates the progression of GC through regulating miR-873-5p/HDGF pathway. +circulation_biomarker_diagnosis_ns 31726271 hsa-mir-155 Neoplasms The DNA circle capture probe was anchored at the top of the tetrahedron DNA nanostructure (TDN) to simultaneously recognize miRNA-21 and miRNA-155 through multiple target recognition domains under the assistance of Helper strands, which could trigger mimetic proximity ligation assay (mPLA) for capturing the beacons ferrocene (Fc)-A1 and methylene blue (MB)-A2 to achieve multiple miRNAs detection. +circulation_biomarker_diagnosis_ns 31726271 hsa-mir-21 Neoplasms The DNA circle capture probe was anchored at the top of the tetrahedron DNA nanostructure (TDN) to simultaneously recognize miRNA-21 and miRNA-155 through multiple target recognition domains under the assistance of Helper strands, which could trigger mimetic proximity ligation assay (mPLA) for capturing the beacons ferrocene (Fc)-A1 and methylene blue (MB)-A2 to achieve multiple miRNAs detection. +tissue_expression_up 31726266 hsa-mir-185 Bipolar Disorder MiR-484, -652-3p, -142-3p remained significantly downregulated and miR-185-5p remained significantly upregulated after accounting for multiple comparisons and adjustments for potential confounders. +tissue_expression_down 31726266 hsa-mir-652 Bipolar Disorder MiR-484, -652-3p, -142-3p remained significantly downregulated and miR-185-5p remained significantly upregulated after accounting for multiple comparisons and adjustments for potential confounders. +tissue_expression_down 31726266 hsa-mir-484 Bipolar Disorder MiR-484, -652-3p, -142-3p remained significantly downregulated and miR-185-5p remained significantly upregulated after accounting for multiple comparisons and adjustments for potential confounders. +tissue_expression_down 31726266 hsa-mir-142 Bipolar Disorder MiR-484, -652-3p, -142-3p remained significantly downregulated and miR-185-5p remained significantly upregulated after accounting for multiple comparisons and adjustments for potential confounders. +lncRNA target 31726250 hsa-mir-146a Wounds and Injuries MicroRNA-146a gets dysregulated in diabetic wounds and injection of this microRNA combined with reactive oxygen species-scavenging cerium oxide nanoparticles (CNPs) can reduce inflammation and improve wound healing; however, a better delivery method than intradermal injections is needed. The sustained release of miRNA146a-tagged cerium oxide nanoparticles from these gels is demonstrated to speed up diabetic wound healing time and significantly reduce inflammation. +therapeutic target 31726199 hsa-mir-210 Glioblastoma MiR210 is overexpressed in GBM and functions as an oncogenic miRNA. +target gene 31726103 hsa-mir-212 Stomach Neoplasms The macrocalyxin C-->miR-212-3p upper and lower left quadrantsSox6 signal pathway was identified to be involved in Sox6 attenuation through augmentation of miR-212-3p values. +virus_miRNA 31725809 hcmv-mir-US22 Human Cytomegalovirus Infections HCMV miR-US22 down-regulation of EGR-1 regulates CD34+ hematopoietic progenitor cell proliferation and viral reactivation +target gene 31725455 hsa-mir-4772 Pleural Effusion, Malignant Downregulation of miR-4772-3p, by targeting Helios, contributes to enhanced Tregs activities in the MPE microenvironment. +other 31725318 hsa-mir-4469 Ovarian Neoplasms, High-Grade Serous 5p may be important miRNAs associated with HGSOC. +other 31725318 hsa-mir-1304 Ovarian Neoplasms, High-Grade Serous 5p may be important miRNAs associated with HGSOC. +other 31725318 hsa-mir-6734 Ovarian Neoplasms, High-Grade Serous 5p may be important miRNAs associated with HGSOC. +genetics_overexpression_promote 31725080 hsa-mir-203 Myocardial Infarction However, overexpressing miR-203 greatly improved the cardiac function, reduced infarct size in rats after MI and weakened infarction-induced apoptosis by increasing Bcl-2 and reducing decreasing Bax, cleaved caspase-3, and cleaved caspase-9. +target gene 31725046 hsa-mir-107 Squamous Cell Carcinoma of Head and Neck Overexpression of microRNA-107 can inhibit the proliferation and invasion of laryngeal carcinoma cells in vitro.The dual-luciferase reporter gene assay confirmed that microRNA-107 bound to the 3'-UTR two positions (202-209, 902-908) of CACNA2D1 mRNA. +genetics_overexpression_suppress 31724825 hsa-mir-130b Sepsis extracellular miR-130b-3p functions as a novel endogenous inhibitor of eCIRP and point to an innovative therapeutic approach to treat inflammatory diseases +target gene 31724536 hsa-mir-129 Osteosarcoma miR-129-5p negatively regulates LHX2 and suppresses the malignant phenotypes of OS. +therapeutic target 31724522 hsa-mir-9 Osteosarcoma Inhibition of miR-9 could be further explored as a therapeutic target to treat OS. +therapeutic target 31724462 hsa-mir-219 Carcinoma, Hepatocellular rendering miR-219 as an optimal target for the prevention and intervention of HCC +genetics_overexpression_suppress 31724454 hsa-mir-139 Melanoma The study validates that miR-139-5p could suppress malignant melanoma progression through the repression of the PI3K/AKT signaling pathway by down-regulating IGF1R +tissue_expression_down 31724439 hsa-mir-124 Arteriosclerosis Plasma miRNA-21 and miRNA192 correlated directly with cerebral hemodynamics parameters of atherosclerosis and arteriosclerosis. MiRNA-124, 125a, 126, 146a showed negative correlations with the same parameters +tissue_expression_down 31724439 hsa-mir-126 Arteriosclerosis Plasma miRNA-21 and miRNA192 correlated directly with cerebral hemodynamics parameters of atherosclerosis and arteriosclerosis. MiRNA-124, 125a, 126, 146a showed negative correlations with the same parameters +tissue_expression_down 31724439 hsa-mir-125a Arteriosclerosis Plasma miRNA-21 and miRNA192 correlated directly with cerebral hemodynamics parameters of atherosclerosis and arteriosclerosis. MiRNA-124, 125a, 126, 146a showed negative correlations with the same parameters +tissue_expression_down 31724439 hsa-mir-146a Arteriosclerosis Plasma miRNA-21 and miRNA192 correlated directly with cerebral hemodynamics parameters of atherosclerosis and arteriosclerosis. MiRNA-124, 125a, 126, 146a showed negative correlations with the same parameters +tissue_expression_up 31724439 hsa-mir-192 Arteriosclerosis Plasma miRNA-21 and miRNA192 correlated directly with cerebral hemodynamics parameters of atherosclerosis and arteriosclerosis. MiRNA-124, 125a, 126, 146a showed negative correlations with the same parameters +genetics_overexpression_promote 31724333 hsa-mir-27a Pancreatic Neoplasms cell-derived exosomes carrying miR-27a promotes HMVEC angiogenesis via BTG2 in PC. +genetics_overexpression_suppress 31724324 hsa-mir-191 Adenocarcinoma of Lung Overexpression of miR-191-5p is capable of blocking the migration and proliferation of lung cancer cells, and its mechanism may be through targeting SATB1 thus downregulating Wnt signaling. +circulation_biomarker_diagnosis_ns 31724319 hsa-mir-107 Prostatic Neoplasms the potential of miR-107 as a non-invasive prostate cancer diagnostic biomarker +target gene 31724259 hsa-mir-142 Glioma inhibition of miR-142-5p or reactivation of Wnt/beta-catenin signaling rescues the inhibition of BRD4 knockdown on glioma cell stemness +lncRNA target 31724220 hsa-mir-18a Colorectal Neoplasms Altogether, our findings suggest that FENDRR exerts an inhibitory role in CRC by interacting with miR-18a-5p and future increases ING4 expression. +genetics_knock down_promote 31724215 hsa-mir-765 Breast Neoplasms The gain-of-function and loss-of-function experiments in vitro indicate that the downregulation of miR-765 suppresses the growth, mobility, and invasion abilities of breast cancer cells by inhibiting ING4. +other 31723119 hsa-mir-148a Retinal Diseases These data suggest that miR-148a/b-3p is a therapeutic candidate for overcoming EC dysfunction and angiogenic disorders, including ischemia, retinopathy, and tumor vascularization. +other 31723119 hsa-mir-148a Ischemia These data suggest that miR-148a/b-3p is a therapeutic candidate for overcoming EC dysfunction and angiogenic disorders, including ischemia, retinopathy, and tumor vascularization. +other 31723119 hsa-mir-148b Ischemia These data suggest that miR-148a/b-3p is a therapeutic candidate for overcoming EC dysfunction and angiogenic disorders, including ischemia, retinopathy, and tumor vascularization. +other 31723119 hsa-mir-148a Neovascularization, Pathologic These data suggest that miR-148a/b-3p is a therapeutic candidate for overcoming EC dysfunction and angiogenic disorders, including ischemia, retinopathy, and tumor vascularization. +other 31723119 hsa-mir-148b Retinal Diseases These data suggest that miR-148a/b-3p is a therapeutic candidate for overcoming EC dysfunction and angiogenic disorders, including ischemia, retinopathy, and tumor vascularization. +other 31723119 hsa-mir-148b Neovascularization, Pathologic These data suggest that miR-148a/b-3p is a therapeutic candidate for overcoming EC dysfunction and angiogenic disorders, including ischemia, retinopathy, and tumor vascularization. +tissue_expression_up 31723098 hsa-mir-129 Skin Aging miR-129-5p is induced in damaged endothelial cells upon exposure to UV radiation, which decreases the cell number +other 31723084 hsa-mir-26b Stanford Type A Aortic Dissection CONCLUSION: miR-26b impeded TAAD development by regulating HMGA2 and TGF-beta/Smad3 signaling pathway, which provided a potential biomarker for TAAD treatment. +genetics_overexpression_promote 31722968 hsa-let-7e Ovarian Neoplasms Contrary to let-7e, PARP1 was overexpressed in cisplatin-resistant ovarian cancer tissues, and patients with high PARP1 expression exhibited poor progression-free survival (PFS) and overall survival (OS). +transcription factor target 31722768 hsa-mir-15a Mastitis We conclude that miR-15a and miR-15a target genes (IRAK2) constitute potential miRNA-mRNA regulatory pairs for use as biomarkers to predict a mastitis response. +transcription factor target 31722768 hsa-mir-15a Staphylococcal Infections We conclude that miR-15a and miR-15a target genes (IRAK2) constitute potential miRNA-mRNA regulatory pairs for use as biomarkers to predict a mastitis response. +circRNA target 31722712 hsa-mir-150 Stomach Neoplasms circLMTK2 functions as a tumour promoter in GC through the miR-150-5p/c-Myc axis and could thus be a prognostic predictor and therapeutic target for GC. +tissue_expression_up 31722571 hsa-mir-16 Cardiotoxicity Circulating levels of several miRNA were significantly altered in CLZ-taking patients compared to healthy volunteers, with miR-16-5p, miR-25-3p, miR-92a-3p, miR-320a-3p, and miR-486-3p upregulated and miR-22-3p, miR-126-3p, and miR-142-3p downregulated in the patients +tissue_expression_down 31722571 hsa-mir-22 Cardiotoxicity Circulating levels of several miRNA were significantly altered in CLZ-taking patients compared to healthy volunteers, with miR-16-5p, miR-25-3p, miR-92a-3p, miR-320a-3p, and miR-486-3p upregulated and miR-22-3p, miR-126-3p, and miR-142-3p downregulated in the patients +tissue_expression_down 31722571 hsa-mir-126 Cardiotoxicity Circulating levels of several miRNA were significantly altered in CLZ-taking patients compared to healthy volunteers, with miR-16-5p, miR-25-3p, miR-92a-3p, miR-320a-3p, and miR-486-3p upregulated and miR-22-3p, miR-126-3p, and miR-142-3p downregulated in the patients +tissue_expression_up 31722571 hsa-mir-25 Cardiotoxicity Circulating levels of several miRNA were significantly altered in CLZ-taking patients compared to healthy volunteers, with miR-16-5p, miR-25-3p, miR-92a-3p, miR-320a-3p, and miR-486-3p upregulated and miR-22-3p, miR-126-3p, and miR-142-3p downregulated in the patients +tissue_expression_up 31722571 hsa-mir-92a Cardiotoxicity Circulating levels of several miRNA were significantly altered in CLZ-taking patients compared to healthy volunteers, with miR-16-5p, miR-25-3p, miR-92a-3p, miR-320a-3p, and miR-486-3p upregulated and miR-22-3p, miR-126-3p, and miR-142-3p downregulated in the patients +tissue_expression_up 31722571 hsa-mir-486 Cardiotoxicity Circulating levels of several miRNA were significantly altered in CLZ-taking patients compared to healthy volunteers, with miR-16-5p, miR-25-3p, miR-92a-3p, miR-320a-3p, and miR-486-3p upregulated and miR-22-3p, miR-126-3p, and miR-142-3p downregulated in the patients +tissue_expression_up 31722571 hsa-mir-20a Cardiotoxicity Circulating levels of several miRNA were significantly altered in CLZ-taking patients compared to healthy volunteers, with miR-16-5p, miR-25-3p, miR-92a-3p, miR-320a-3p, and miR-486-3p upregulated and miR-22-3p, miR-126-3p, and miR-142-3p downregulated in the patients +transcription factor target 31722554 hsa-mir-141 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 3p regulates T-ALL cell progression by directly targeting TRAF5, and may serve as a potential therapeutic target for T-ALL. +lncRNA target 31722341 hsa-mir-21 Stomach Neoplasms However, the downregulation of EMT was found to accompany the inhibition of invasion and migration of GC cells after downregulation of miRNA-21 expression due to the transfection of an miRNA-21 inhibitor. +transcription factor target 31722236 hsa-mir-181c Social Isolation, Post Stroke In summary, present data suggests that miR-181c-5p is a potential target for post-stroke SI. +other 31722012 hsa-mir-214 Cardiomyopathies discovered that the miR3p/NLRC5 axis is important for fibroblast-to-myofibroblast transition (FMT) and ECM remodelling in a pressure overload model of fibrosis [Clin. +circulation_biomarker_diagnosis_up 31721935 hsa-mir-21 acute myocardial infarction miR-21 and NLR play a role in the diagnosis of AMI and can be used as predictors for the survival of AMI. +circulation_biomarker_diagnosis_up 31721725 hsa-mir-485 Thyroid Cancer, Papillary Plasma exosomal miR-485-3p and miR-4433a-5p might serve as biomarkers for PTC diagnosis. +circulation_biomarker_diagnosis_up 31721725 hsa-mir-4433a Thyroid Cancer, Papillary Plasma exosomal miR-485-3p and miR-4433a-5p might serve as biomarkers for PTC diagnosis. +genetics_GWAS 31721599 hsa-mir-155 Ischemic Stroke The miR-155 rs767649 polymorphism does not seem to be a key determinant of IS risk, whereas the AT1R rs1492099 polymorphism is linked to reduced LAA-stroke risk, and the rs275653 AA genotype is potentially protective against SAO strokes. +other 31721543 hsa-mir-193b Carcinoma in Situ RESULTS: Stepwise upregulated SNHG7 in colon advanced adenomas and early-stage cancer negatively correlates with miR-193b level, the direct interaction was confirmed in vitro. +other 31721543 hsa-mir-193b Colorectal Neoplasms, Hereditary Nonpolyposis RESULTS: Stepwise upregulated SNHG7 in colon advanced adenomas and early-stage cancer negatively correlates with miR-193b level, the direct interaction was confirmed in vitro. +other 31721543 hsa-mir-193b Colonic Neoplasms METHODS: The level of SNHG7 and microRNA-193b (miR-193b) was detected by qRT-PCR in colon tumor tissues and cells. The interaction of SNHG7 and miR-193b and the influence of SNHG7 silencing on colon tumor cells was evaluated. +other 31721298 hsa-mir-16 Pyelonephritis Cats with PN had significantly upregulated miR-16 with a mean log2fold change of 1.0 /- 0.4 SD, compared with controls (-0.1 /- 0.2, P = .01) and other urological conditions (0.6 /- 0.3, P = .04). +genetics_overexpression_promote 31721211 hsa-mir-134 Glioma The overexpression of miR +lncRNA target 31721085 hsa-mir-223 Prediabetic State RESULTS: We identified two miRNAs, miR-10b and miR3p, which target components of the insulin signaling pathway and whose ratio discriminates between these two subgroups of prediabetic individuals at a stage at which other features, including glycemia, are less proficient at separating them. +lncRNA target 31721085 hsa-mir-223 Diabetes Mellitus, Type 2 RESULTS: We identified two miRNAs, miR-10b and miR3p, which target components of the insulin signaling pathway and whose ratio discriminates between these two subgroups of prediabetic individuals at a stage at which other features, including glycemia, are less proficient at separating them. +lncRNA target 31721085 hsa-mir-10b Diabetes Mellitus, Type 2 RESULTS: We identified two miRNAs, miR-10b and miR3p, which target components of the insulin signaling pathway and whose ratio discriminates between these two subgroups of prediabetic individuals at a stage at which other features, including glycemia, are less proficient at separating them. +lncRNA target 31721085 hsa-mir-10b Prediabetic State RESULTS: We identified two miRNAs, miR-10b and miR3p, which target components of the insulin signaling pathway and whose ratio discriminates between these two subgroups of prediabetic individuals at a stage at which other features, including glycemia, are less proficient at separating them. +lncRNA target 31720660 hsa-mir-128 Myocarditis Finally, we concluded that selenium inhibits the occurrence of oxidative stress and ultimately alleviates myocardial inflammation induced by LPS through the miR3p-p38MAPK-NF-kappaB pathway. +genetics_knock down_promote 31719795 hsa-mir-205 Ovarian Neoplasms CONCLUSION: This study suggests that exosomes from donor ovarian cancer cell SKOV3 shuttled miR-205 could participate in the regulation of the proliferation, migration, invasion, apoptosis as well as EMT progression of receptor SKOV3 cells by targeting VEGFA. +circulation_biomarker_diagnosis_down 31719576 hsa-mir-34c Nephritis, Interstitial Interestingly, in the serum of the animals treated with T2 there was a general decrease of miRNAs with miR-22a-3p, miR-34c-5p and miR-33a-3p significantly downregulated. +circulation_biomarker_diagnosis_down 31719576 hsa-mir-22a Nephritis, Interstitial Interestingly, in the serum of the animals treated with T2 there was a general decrease of miRNAs with miR-22a-3p, miR-34c-5p and miR-33a-3p significantly downregulated. Furthermore, miR-22a-3p had the largest variation pointing toward its preeminent role in T2 metabolic effect. +circulation_biomarker_diagnosis_down 31719576 hsa-mir-33a Nephritis, Interstitial Interestingly, in the serum of the animals treated with T2 there was a general decrease of miRNAs with miR-22a-3p, miR-34c-5p and miR-33a-3p significantly downregulated. +lncRNA target 31719211 hsa-mir-130a Stomach Neoplasms Then, we verified that circGRAMD1B served as a sponge that targeted miR-130a-3p in GC cells; circGRAMD1B alleviated GC cell proliferation, migration, and invasion by targeting miR-130a-3p. +genetics_overexpression_promote 31718630 hsa-mir-199a Thyroid Cancer, Papillary miR-199a-3p overexpression failed to significantly affect DLG1-AS1, while DLG1-AS1 overexpression resulted in downregulated miR-199a-3p, In addition, DLG1-AS1 overexpression promoted the proliferation of PTC cells. +genetics_overexpression_promote 31718618 hsa-mir-155 Thyroid Carcinoma, Anaplastic CONCLUSIONS: Aberrant miR-155/SOCS1 expression has been included in ATC progression: miR-155 overexpression leads to SOCS1 suppression and develops ATC progression. +genetics_overexpression_promote 31718519 hsa-mir-421 Osteosarcoma The overexpression of miR-421 induced cell proliferation, invasion, and migration, and the release of pro-inflammatory IL-6 in cultured human osteosarcoma cells. +other 31717959 hsa-mir-197 Carcinoma, Hepatocellular MiR-3197 shows some potential for the identification of patients at risk of HCC during DAA treatments. +transcription factor target 31717759 hsa-mir-27a Colorectal Neoplasms Moreover, we found that miRNA-27a could restore the tumor inhibition effect of cetuximab in KRAS-mutant CRC cells. +transcription factor target 31717435 hsa-mir-1258 Colorectal Neoplasms In CRC, miR-1258 expression also decreased cell proliferation and migration in vitro and tumor growth in vivo, similar to cells with silenced CKS1B expression. Considering the highly increased levels of CKS1B and decreased expression of miR-1258 in tumors from CRC patients, these findings suggest that miR-1258 may play tumor-suppressive roles by targeting CKS1B expression in CRC. +other 31715633 hsa-mir-34a Coronary Artery Disease Therefore, the combination of miR-34a-5p and FIB may serve as an efficient tool for distinguishing PTS in SCAD patients. +other 31715506 hsa-mir-457b Neurotic Disorders 5p, and dre-miR-457b-5p. +lncRNA target 31715081 hsa-mir-133b Pancreatic Carcinoma Moreover, microRNA-133b suppressed PDAC cell invasion and migration by inhibiting the EMT through targeting HULC. +genetics_overexpression_suppress 31714185 hsa-mir-1 Urinary Bladder Neoplasms CONCLUSION: Overexpression of microRNA-1 inhibited cell proliferation and induced cell-cycle arrest of bladder cancer cells through targeting Golgi phosphoprotein 3 and regulation of Foxo1. +transcription factor target 31713992 hsa-mir-125b Borderline Personality Disorder These results suggest that miR-125b helps protect against BPD as a downstream target of Nrf2. +genetics_overexpression_promote 31713929 hsa-mir-92b Stomach Neoplasms Overexpression of DAB2IP rescued the effects of miR-92b in GC cells. +lncRNA target 31713924 hsa-mir-194 Triple Negative Breast Neoplasms Therefore, this study was aimed to study the effect of applying linoleic acid (LA) and docosahexaenoic acid (DHA) fatty acids alone or combined with Taxol on the expression of the matrix metalloproteinase (MMP)-9, MMP-2, vimentin, and talin2 genes, tumor-suppressor miR-194 and, onco-miR-106b in triple-negative breast cancer cell line, known as MDA-MB-231. +lncRNA target 31713924 hsa-mir-106b Triple Negative Breast Neoplasms Therefore, this study was aimed to study the effect of applying linoleic acid (LA) and docosahexaenoic acid (DHA) fatty acids alone or combined with Taxol on the expression of the matrix metalloproteinase (MMP)-9, MMP-2, vimentin, and talin2 genes, tumor-suppressor miR-194 and, onco-miR-106b in triple-negative breast cancer cell line, known as MDA-MB-231. +lncRNA target 31713921 hsa-mir-92a Pancreatitis Collectively, the data obtained from the present study demonstrated that reduced miR-92a-3p expression may relieve AP through its suppressive effects on cell apoptosis, inflammatory factors, and facilitatory effects on cell proliferation by enhancing KLF2 expression. +other 31713817 hsa-mir-138 Glioma In this study, a novel established regulatory way of LINC00174/miR5p/SOX9 axis was systematically studied, which may provide a new manner for glioma therapy. +lncRNA target 31713780 hsa-mir-196 Carcinoma, Hepatocellular 5p/HMGA2 pathway serving as a potential target for future therapeutic intervention. +genetics_knock down_promote 31713587 hsa-mir-4429 Glioblastoma Overexpression of SP1 or miR-4429 inhibitor could partly abolish the effect of DLEU1 knockdown on cell viability and apoptosis in GBM. Accordingly, our experimental data revealed that SP1-DLEU1-miR-4429 formed a feedback loop to promote GBM development, providing a new evidence for the role of DLEU1 in GBM. +genetics_overexpression_suppress 31713484 hsa-mir-22 Alzheimer Disease 3p overexpression reduced Abeta deposit and alleviated AD symptoms by targeting and regulating MAPK14 expression, which ameliorated AD symptoms. +transcription factor target 31713483 hsa-mir-212a Neuralgia CONCLUSION: The expression of miR-212a-3p attenuates neuropathic pain by targeting NaV1.3. +transcription factor target 31713483 hsa-mir-212 Neuralgia CONCLUSION: The expression of miR-212a-3p attenuates neuropathic pain by targeting NaV1.3. +transcription factor target 31713440 hsa-mir-34a Hyperglycemia Bcl2 and pAKT/AKT protein expressions in the HG group was significantly lower than that in controls, but AS-IV and miR-34a-inhibitor antagonized the process. +lncRNA target 31713278 hsa-mir-17 Prostatic Neoplasms CONCLUSION: Circ-MTO1 correlates with decreased pathological T/N stage and favorable survival profiles, and it also inhibits cell proliferation, invasion as well as miR +exosome 31713003 hsa-mir-210 Pancreatic Carcinoma CONCLUSIONS: Our findings suggest that exosomes derived from GEM-resistant pancreatic cancer stem cells mediate the horizontal transfer of drug-resistant traits to GEM-sensitive pancreatic cancer cells by delivering miR-210. +transcription factor target 31712854 hsa-mir-140 Osteoarthritis 5p could inhibit the PI3K/AKT signaling pathway and suppress the progression of OA through targeting HMGB1. +genetics_knock down_promote 31712637 hsa-mir-4534 Prostatic Neoplasms The biological functions of RBMS3-AS3, miR-4534, and VASH1 on cell proliferation, migration, invasion, and angiogenesis of prostate cancer were evaluated via gain- and loss-of-function experiments. +tissue_expression_up 31712582 hsa-mir-397 Hepatolenticular Degeneration Musa-miR397 was significantly upregulated (8-10) fold in banana roots and leaves under copper deficiency, correlating with expression of root copper deficiency marker genes such as Musa-COPT and Musa-FRO2. +circulation_biomarker_diagnosis_ns 31712567 hsa-mir-223 Schizophrenia Our results reveal an increase in miR-223 in plasma during both the first episode and the later stage of schizophrenia, which may affect the expression of cell migration-related genes targeted by miR-223. +genetics_knock down_promote 31712391 hsa-mir-152 Multiple Myeloma Taking these results together, H19 knockdown suppresses MM tumorigenesis via inhibiting BRD4-mediated cell proliferation through targeting miR +other 31711985 hsa-mir-425 Diabetes Mellitus This study showed that miR5p was significantly upregulated in diabetic patients and human umbilical vein endothelial cells (HUVECs) treated with high glucose (HG) and interleukin-1beta (IL-1beta). +genetics_overexpression_promote 31711673 hsa-mir-106a Osteosarcoma Functionally, the enforced expression of miR-106a-5p significantly suppressed proliferation and invasion of osteosarcoma cells, while the overexpression of RUNX1 effectively reversed its suppressive roles. +genetics_overexpression_promote 31711559 hsa-mir-561 Carcinoma, Non-Small-Cell Lung Particularly, P-REX2a silencing recapitulated the cellular and molecular effects observed upon miR-561 overexpression, and P-REX2a overexpression counteracted the effects of miR-561 overexpression on NSCLC cells. +lncRNA target 31711313 hsa-mir-203 Osteoarthritis Suppression of miR-203 using a specific inhibitor ameliorated cartilage degradation in postmenopausal OA rats. +circulation_biomarker_diagnosis_up 31711127 hsa-mir-146a Peripartum Cardiomyopathy Thus, measuring circulating PAI-1 and miR-146a, together with an uPAR/NF-kappaB-activity assay could be developed into a specific diagnostic marker assay for PPCM, but unrestricted reduction of PAI-1 for therapy may not be advised. +genetics_overexpression_promote 31711057 hsa-mir-34a Stomach Neoplasms CONCLUSIONS: miR-34a could modulate the susceptibility of GC to PD via targeting survivin, suggesting miR-34a overexpression may serve as a novel strategy to sensitize GC to anti-cancer drugs. +lncRNA target 31710596 hsa-mir-27a Epilepsy CONCLUSIONS Our preliminary findings indicated that miR-27a-3p inhibitor protected against epilepsy-induced inflammatory response and hippocampal neuronal apoptosis by targeting MAP2K4. +circulation_biomarker_diagnosis_ns 31710594 hsa-mir-27a Polycystic Ovary Syndrome Real-time PCR was used to verify the expression of eight of these miRNAs, among which miR-27a-5p was the most significantly elevated in PCOS patients serum exosomes. Thus, serum exosomal miR-27a-5p may play a role in EC development in PCOS patients. +circulation_biomarker_diagnosis_ns 31710594 hsa-mir-27a Endometrial Neoplasms Real-time PCR was used to verify the expression of eight of these miRNAs, among which miR-27a-5p was the most significantly elevated in PCOS patients serum exosomes. Thus, serum exosomal miR-27a-5p may play a role in EC development in PCOS patients. +circulation_biomarker_diagnosis_up 31710448 hsa-mir-34a Esophageal Squamous Cell Carcinoma CONCLUSIONS: Plasma miR-34a may serve as a potential biomarker in detecting early stages of the EC. +other 31710446 hsa-mir-133a Diabetes Mellitus, Type 2 Therefore, we investigated the correlation of miR-103 and miR-133a expression with the ANGPTL8 and other type 2 diabetes mellitus (T2DM)-related factors. +circulation_biomarker_diagnosis_up 31710446 hsa-mir-103 Diabetes Mellitus, Type 2 There was a positive and significant correlation between miR-103/133a with triglycerides (TG), total cholesterol, fasting blood sugar (FBS), and glycated hemoglobin (p < 0.05) in the T2D group. +circulation_biomarker_diagnosis_ns 31710444 hsa-mir-499a Pancreatic Carcinoma Moreover, when serum miR-499a-5p was combined with CA199, the diagnostic value for pancreatic cancer increased significantly (p < 0.05). +circulation_biomarker_diagnosis_ns 31710429 hsa-mir-937 Mucocutaneous Lymph Node Syndrome Beckground: The current study aims to investigate whether miR-937 can be used as a diagnostic biomarker in peripheral blood mononuclear cells (PBMCs) for children with Kawasaki disease (KD) with or without coronary artery dilation (CAD). +transcription factor target 31710102 hsa-mir-150 Myocarditis Thus, miR5p may be a novel promising target for treating diabetic cardiomyopathy. +transcription factor target 31710102 hsa-mir-150 Diabetic Nephropathies Thus, miR5p may be a novel promising target for treating diabetic cardiomyopathy. +circulation_biomarker_diagnosis_up 31709859 hsa-mir-155 Heart Failure The area under the receiver operating characteristic curve of serum miRNA-155 in the diagnosis of HF after MI was 0.941, the cutoff value was 1.77, sensitivity was 92.73%, and specificity was 92.14%. +lncRNA target 31709761 hsa-mir-145 Reperfusion Injury, Cerebral Ischemia In summary, our results suggested that lncRNA TUG1 may function as a competing endogenous RNA (ceRNA) for miR-145 to induce cell damage, possibly providing a new therapeutic target in cerebral ischaemia/reperfusion injury. +genetics_overexpression_promote 31709719 hsa-mir-922 Stomach Neoplasms In addition, overexpression of miR-922 observably restrained the apoptosis of SGC7901 cells and promoted SGC7901 cell proliferation, migration, and invasion. +transcription factor target 31709707 hsa-mir-200 Genetic Diseases, Inborn Delivery of miR-200 by SLN further increases the cytotoxicity of irinotecan-loaded liposomes against CRC cells by triggering apoptosis and suppressing RAS/beta-catenin/ZEB/multiple drug resistance (MDR) pathways. +lncRNA target 31709644 hsa-mir-28 Colonic Neoplasms 5p expression downregulated the expression of CAMTA2 significantly and the restoration of CAMTA2 expression abolished the inhibitory effect of miR +genetics_overexpression_suppress 31709636 hsa-mir-760 Esophageal Squamous Cell Carcinoma Cell counting kit-8 (CCK-8) assay, colony formation assay, transwell assay, and flow cytometry denoted that induced ectopic overexpression of miR-760 dramatically inhibited ESCC cells proliferation, attenuated migration, and invasion facilitated apoptosis in vitro. +lncRNA target 31709617 hsa-mir-3163 Colorectal Neoplasms Mechanistcally, EIF3J-AS1 was upregulated by cAMP-response element-binding protein-binding protein-mediated histone H3 on lysine 27 acetylation (H3K27ac) at the promoter region, and EIF3J-AS1 upregulated YAP1 expression through sponging miR-3163 in CRC cells. In conclusion, we first found that H3K27 acetylation-induced lncRNA EIF3J-AS1 improved proliferation and impeded apoptosis of colorectal cancer through the miR-3163/YAP1 axis, which might potentially provide a novel molecular-targeted strategy for CRC treatment. +lncRNA target 31709597 hsa-mir-204 Maxillary Sinus Neoplasms Taken together, these results revealed a novel regulatory mechanism KCNQ1OT1/miR-204/EphA7 axis, which could provide a new understanding of MSSCC tumorigenesis and develop potential targets for MSSCC therapy. +lncRNA target 31709544 hsa-mir-3163 Colorectal Neoplasms MAGI2-AS3 drives CRC progression through regulating miR-3163/TMEM106B axis. +genetics_GWAS 31709191 hsa-mir-143 Leukemia, Myeloid, Acute High miR-143 expression is significantly associated with better prognosis in AML patients with DNMT3A mutations. +lncRNA target 31709182 hsa-mir-622 Breast Neoplasms To further validate our bioinformatic results, the regulatory axis of miR-622 and RNF8, one of the hub genes recently reported to promote breast cancer cell EMT process and breast cancer metastasis, was selected as in vitro proof of concept. We not only identified the hub target genes of miR-622 in silico but also revealed the regulatory mechanism of miR-622 in breast cancer cell EMT process, viability, and migration in vitro for the first time. +lncRNA target 31708788 hsa-mir-499 Myocardial Infarction Collectively, deletion of NPY reduced myocardial ischemia, improved cardiac function, and inhibited cardiomyocyte apoptosis by NPY type 1 receptor-miR +lncRNA target 31708788 hsa-mir-499 Heart Diseases Collectively, deletion of NPY reduced myocardial ischemia, improved cardiac function, and inhibited cardiomyocyte apoptosis by NPY type 1 receptor-miR +lncRNA target 31708690 hsa-mir-124 Glioma CONCLUSIONS: Our results demonstrate that p62 can be targeted by miR3p and acts as an oncogene in glioma, suggesting the potential value of p62 as a novel therapeutic target for glioma. +other 31708373 hsa-mir-451 Carcinoma CONCLUSION: MicroRNA-451 may serve as a promising clinical prognostic biomarker in various carcinomas. +other 31708034 hsa-mir-4521 Hemophilia A A sensitive and selective electrochemical method for simultaneous detection of two hemophilia A-related microRNAs (miR-1246 and miR-4521) was developed. +other 31708034 hsa-mir-1246 Hemophilia A A sensitive and selective electrochemical method for simultaneous detection of two hemophilia A-related microRNAs (miR-1246 and miR-4521) was developed. +circulation_biomarker_diagnosis_ns 31707807 hsa-mir-29 Atrial Fibrillation These changes in AF susceptibility were associated with a decrease in circulating microRNA-21 and microRNA-29 during the first 2 months of exercise with partial normalization at 3 months in both transgenic and WT animals. +circulation_biomarker_diagnosis_ns 31707807 hsa-mir-21 Cardiomyopathies These changes in AF susceptibility were associated with a decrease in circulating microRNA-21 and microRNA-29 during the first 2 months of exercise with partial normalization at 3 months in both transgenic and WT animals. +circulation_biomarker_diagnosis_ns 31707807 hsa-mir-21 Atrial Fibrillation These changes in AF susceptibility were associated with a decrease in circulating microRNA-21 and microRNA-29 during the first 2 months of exercise with partial normalization at 3 months in both transgenic and WT animals. +circulation_biomarker_diagnosis_ns 31707807 hsa-mir-29 Cardiomyopathies These changes in AF susceptibility were associated with a decrease in circulating microRNA-21 and microRNA-29 during the first 2 months of exercise with partial normalization at 3 months in both transgenic and WT animals. +other 31707599 hsa-mir-9 Carcinoma, Non-Small-Cell Lung The expression levels of IL-17A gene and miR-9 was assessed in 26 NSCLC tissue samples and 26 unchanged lung tissue adjacent to lung tumors (control tissue), using qPCR. +other 31707396 hsa-mir-203 Diabetic Foot CONCLUSIONS: The upregulation of miR-203 in DFU tissues impaired wound healing by the repress EMT process. +circulation_biomarker_diagnosis_up 31707340 hsa-mir-424 Norrie disease RESULTS: CDKN2B-AS1 expression was up-regulated and miR5p level was down-regulated in peripheral blood of DN patients and high glucose-treated HGMC cells. +other 31707336 hsa-mir-497 Diabetes Mellitus In conclusion, miRNA-497, with its down-regulation activity for pro-inflammatory cytokines, is proposed as a potential therapeutic agent for diabetic wound healing. +genetics_GWAS 31707205 hsa-mir-146a Alzheimer Disease MicroRNA-146a-5p (miR-146a) is well known in the regulation of the inflammatory response, and the functional SNP of miR-146a was associated with AD risk. +lncRNA target 31706574 hsa-mir-130a Osteosarcoma Taken together, MIR17HG displays the tumor-promotive role in the progression of OS through SP1/MIR17HG/miR-130a-3p/SP1 feedback loop. +other 31706102 hsa-mir-371b Urinary Bladder Neoplasms Furthermore, duel-luciferase reporter assay revealed that AC114812.8 could regulate the FUT4 expression level by sponging miR-371b-5p to facilitate BC progression. Rescue experiments showed that miR-371b-5p could rescue the effect of AC114812.8 on proliferation and metastasis of BC. +circRNA target 31706100 hsa-mir-149 Uterine Cervical Neoplasms 5p/AURKA axis, which provided a novel therapeutic target for cervical cancer treatment. +other 31706051 hsa-mir-429 Breast Neoplasms These findings further reveal the possible mechanism and effect of the miR-429/CrkL/MMP-9 regulatory axis in the bone microenvironment in breast cancer bone metastasis. +genetics_knock down_promote 31706018 hsa-mir-485 Carcinoma, Hepatocellular Next, gain- or loss-of-function studies were applied in the HCC cell line (Huh7) to examine the effects of miR +circulation_biomarker_diagnosis_ns 31706013 hsa-mir-483 Osteoporosis 5p and low-expressed IGF2 were frequently found in the serums and bone tissues derived from osteoporotic patients. +genetics_overexpression_suppress 31705975 hsa-mir-214 Ovarian Neoplasms We aimed to inhibit overexpressed oncomiR-214 in cisplatin (CIS)-resistant ovarian cancer (OC) and perform targeted therapy of sensitized cells using a novel polymeric drug delivery system (DDS). +genetics_overexpression_promote 31705929 hsa-mir-193b Carcinoma, Hepatocellular Forced overexpression of H19 attenuated miR-193b-mediated inhibition on multiple driver oncogenes (EGFR, KRAS, PTEN and IGF1R) and MAPK1 gene, thus triggered EMT and stem cell transformation in HCC. TAMs-induced lncRNA H19 promotes HCC aggressiveness via triggering and activating the miR-193b/MAPK1 axis, mediates the crosstalk between HCC and immunological microenvironment, and causes poor clinical outcomes. +genetics_overexpression_promote 31705901 hsa-mir-505 Breast Neoplasms 3p inhibited runt-related transcription factor 2 (RUNX2) expression by directly bind to its 3'- untranslated region (3'-UTR) and overexpression of RUNX2 partially reversed the effect of miR +lncRNA target 31705333 hsa-mir-214 Triple Negative Breast Neoplasms 3p could suppress the viability, migration, invasion and EMT of TNBC cells though targeting ST6GAL1, which might be a potential target for future treatment of TNBC. +lncRNA target 31705194 hsa-mir-21 Liver Neoplasms Our data demonstrated that GAS5 functioned as a tumor suppressor role in HCC through regulation of miRPTEN singling pathways, suggesting a potential application of GAS5 in HCC therapy. +other 31705013 hsa-mir-199b Polycystic Ovary Syndrome 3p correlated with C-reactive protein (CRP). +other 31705013 hsa-mir-381 Polycystic Ovary Syndrome 3p correlated with FAI. +other 31705013 hsa-mir-93 Polycystic Ovary Syndrome 3p correlated with C-reactive protein (CRP). +other 31705013 hsa-mir-382 Polycystic Ovary Syndrome 3p correlated with FAI. +other 31705013 hsa-mir-127 Polycystic Ovary Syndrome 3p correlated with FAI. +other 31705013 hsa-mir-425 Polycystic Ovary Syndrome 3p correlated with FAI. +lncRNA target 31704767 hsa-mir-137 Neuroendocrine Tumors We show that a top-ranked miR-137 candidate gene, Sorl1, has a tumor suppressor function in primary PanNETs. +lncRNA target 31704767 hsa-mir-137 Pancreatic Carcinoma We show that a top-ranked miR-137 candidate gene, Sorl1, has a tumor suppressor function in primary PanNETs. +genetics_overexpression_promote 31704611 hsa-mir-24 Squamous Cell Carcinoma of Head and Neck Additionally, overexpression of miR +lncRNA target 31704502 hsa-mir-141 Colorectal Neoplasms 3p enhanced the cetuximab sensitivity of CRC cells by EGFR suppression. +exosome 31704348 hsa-mir-126 Spinal Cord Injuries These findings suggest that exosomes derived from miR +lncRNA target 31704096 hsa-mir-214 Neuroblastoma In conclusion, miR-214 protected against isoflurane-induced neurotoxicity in SH-SY5Y cells via regulation of PI3K/Akt pathway by targeting PTEN, contributing to better understanding the underlying mechanisms of anesthetics-induce neurotoxicity. +lncRNA target 31703725 hsa-mir-182 Ovarian Neoplasms Subsequently, we analyzed the gene overlaps integrated between DEGs in OC and predicted target genes of miR-182 by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. +circRNA target 31703640 hsa-mir-370 Uterine Cervical Neoplasms circAGFG1 promoted proliferation and migration of CC cells via enhancing the activity of RAF/MEK/ERK pathway by sponging miR +lncRNA target 31703591 hsa-mir-1270 Carcinoma, Hepatocellular Finally, we also found that miR-1270 was a negative regulator and participated in post-transcriptional regulation of CENPM, and hepatitis B virus X protein (HBx) can promote hepatocellular carcinoma by suppressing miR1270. +other 31703465 hsa-mir-155 Adenocarcinoma of Lung In ADC, miR-155 correlated with AXL and IL6R expression, which were related to the presence of EMT CTC1 (p = 0.014 and p = 0.004). +lncRNA target 31703316 hsa-mir-99a Down Syndrome GATHER functional enrichment analysis of miRWalk3.0-predicted targets from Down syndrome amniocytes and fetal hearts transcriptome GEODataSets outlined both focal adhesion and cytokine-cytokine receptor interaction signaling as novel signaling pathways impacted by miR-99a and associated with cardiac defects in female Down syndrome patients. +circulation_biomarker_diagnosis_ns 31703221 hsa-mir-148a Stomach Neoplasms For the early diagnosis of gastric cancer, microRNA-148a (miRNA-148a) as a promising biomarker is measured by a simple colorimetric biosensor due to its unique surface plasmon resonance (SPR) absorption of gold nanoparticles (AuNPs). +other 31703106 hsa-mir-155 Asthma Additional significant associations were observed between miR5p with symptomatic asthma, negative bronchodilation with symptoms and positive bronchodilation without symptoms. +circulation_biomarker_diagnosis_ns 31703079 hsa-mir-33a Non-alcoholic Fatty Liver Disease CONCLUSIONS: Our data indicate that circulating miR-33a is an independent predictor of liver steatosis and inflammation in patients after liver transplantation. +circulation_biomarker_diagnosis_ns 31703079 hsa-mir-33a Inflammation CONCLUSIONS: Our data indicate that circulating miR-33a is an independent predictor of liver steatosis and inflammation in patients after liver transplantation. +circulation_biomarker_diagnosis_ns 31703079 hsa-mir-33a Fatty Liver CONCLUSIONS: Our data indicate that circulating miR-33a is an independent predictor of liver steatosis and inflammation in patients after liver transplantation. +transcription factor target 31702994 hsa-mir-6165 Colorectal Neoplasms Moreover, a lower expression level of miR-6165 was detected in high-grade colorectal tumors compared with low-grade tumors. Taken together, the results of our study suggest a tumor suppressive role of miR-6165 in colorectal cancer, which seems to take place by regulating IGF-1R gene expression. +transcription factor target 31702814 hsa-mir-217 Diabetic Retinopathy Therefore, our findings suggested that miR217 inhibitor protected against retinal epithelial cell damage caused by high glucose via targeting SIRT1, thereby playing a protective role in diabetic retinopathy. Targeting miR217 may have therapeutic potential in the treatment of diabetic retinopathy. +genetics_overexpression_promote 31702805 hsa-mir-21 Acute Lung Injury, Hyperoxic miR215p overexpression also increased AKT phosphorylation in AEC II cells from the HALI lungs compared with that of the HALI alone group and the control virus group. +other 31702616 hsa-mir-146a Pulmonary Arterial Hypertension A strong evidence indicated lack of association between rs2910164 in miR-146a and CHD. +lncRNA target 31702512 hsa-mir-892b Osteosarcoma CONCLUSION: Thus, the circEPSTI1-miR-892b-MCL1 axis affected osteosarcoma progression through the miRNA sponging mechanism. +genetics_overexpression_promote 31702493 hsa-mir-542 Epilepsy 3p mimic showed a suppressive effect on these KA-induced protein levels, whereas TLR4 overexpression ameliorated the miR +lncRNA target 31702491 hsa-mir-7 Duane Retraction Syndrome This study investigated the effect of miR-7 in the regulation of cell proliferation via the HoxB3 gene and PI3K/AKT/mTOR signaling pathways in DR. +transcription factor target 31702491 hsa-mir-7 Diabetic Retinopathy CONCLUSION: Our findings demonstrate that miR-7 regulates the growth of retinal epithelial cells through various pathways and is a potential therapeutic target for the prevention and treatment of diabetic retinopathy. +genetics_overexpression_promote 31702393 hsa-mir-145 Esophageal Squamous Cell Carcinoma In ESCC cells, EGFR-AS1 overexpression led to upregulated ROCK1, while miR-145 overexpression led to downregulated ROCK1 and reduced effects of EGFR-AS1 overexpression. Conclusion: Therefore, EGFR-AS1 may upregulate ROCK1 by sponging miR-145 to promote ESCC cell invasion and migration. +genetics_overexpression_promote 31702382 hsa-mir-122 Squamous Cell Carcinoma of Head and Neck In OSCC cells, LINC00974 overexpression resulted in upregulated, whereas overexpression of miR-122 led to downregulated RhoA. +genetics_knock down_promote 31702057 hsa-mir-802 Glioblastoma Altogether, the overexpression of miR-802 restrained cell proliferation, invasion, and EMT of GBM cells via the regulation of SIX4. +transcription factor target 31702045 hsa-mir-195 Rectal Neoplasms The tumor suppressive ability of miR195 in rectal cancer cell proliferation and metastasis was mediated by blocking IGF1 expression and inhibiting the PI3K/AKT pathway. +other 31702033 hsa-mir-186 Osteonecrosis These results highlight the possible clinical value of miR1865p in treatment for nontraumatic ON. +lncRNA target 31702027 hsa-mir-125a Breast Neoplasms MicroRNA (miR)125a5p has shown the potential for suppressing tumorigenesis and development; however, the effects of miR125a5p on breast cancer cells remains unknown. The aim of this study was to evaluate the effects and underlying mechanisms of miR125a5p in MCF7 breast cancer cells. +genetics_knock down_promote 31702021 hsa-mir-483 Osteoporosis Therefore, the present study suggested that miR4833p promoted osteogenic differentiation of BMSCs by targeting STAT1, and miR4833 prepresent a potential therapeutic target for agerelated bone loss. +genetics_knock down_promote 31702021 hsa-mir-4833 Osteoporosis Therefore, the present study suggested that miR4833p promoted osteogenic differentiation of BMSCs by targeting STAT1, and miR4833 prepresent a potential therapeutic target for agerelated bone loss. +lncRNA target 31701767 hsa-mir-1304 Stomach Neoplasms Mechanism analysis showed that circ-PRMT5 sponged miR-145/miR-1304 to upregulate MYC expression and GC development.Conclusion: Our findings demonstrated that circ-PRMT5 function as an oncogene in GC patients by targeting miR-145/miR-1304/MYC axis. High circ-PRMT5 expression may provide a poor prognostic indicator of survival in GC patients and targeting circ-PRMT5/miR-145/miR-1304/MYC axis may be a novel therapeutic strategy for GC. +lncRNA target 31701767 hsa-mir-145 Stomach Neoplasms Mechanism analysis showed that circ-PRMT5 sponged miR-145/miR-1304 to upregulate MYC expression and GC development.Conclusion: Our findings demonstrated that circ-PRMT5 function as an oncogene in GC patients by targeting miR-145/miR-1304/MYC axis. High circ-PRMT5 expression may provide a poor prognostic indicator of survival in GC patients and targeting circ-PRMT5/miR-145/miR-1304/MYC axis may be a novel therapeutic strategy for GC. +transcription factor target 31701656 hsa-mir-576 Pre-Eclampsia 5p targeting TFAP2A deserve further investigation in order to explore their potential role in PE. +exosome 31701195 hsa-mir-28 Leukemia Compared with the corresponding controls, the alkalized exosomes with or without miR328 sensitized the chronic leukemia cells to imatinib. Taken together, our study has revealed that lysosomal clearance of miR328 in imatinib-resistant cells at least partially contributes to the drug resistance, while delivery of alkalized exosomes would sensitize the chromic leukemia cells to imatinib. +other 31700891 hsa-mir-1 Cardiomegaly BACKGROUND: The functions of microRNA-1 (miR-1) in cardiac hypertrophy, and cardiomyocyte differentiation have been investigated. +circulation_biomarker_diagnosis_ns 31700885 hsa-mir-146a Hepatitis B, Chronic Background To investigate the association of plasma miR-146a with serological conversion of hepatitis B e-antigen (HBeAg) in patients with chronic hepatitis B (CHB) treated with nucleotide analogs (NAs). Conclusions miR-146a48w was independently associated with seroconversion of HBeAg in CHB patients treated with NAs. +other 31700619 hsa-mir-181c Cerebral Cortical Thinning No significant associations were found between lower miR-181c-5p levels and cognitive deficits or cortical thinning. +circulation_biomarker_diagnosis_ns 31700619 hsa-mir-181c Cerebrovascular Disorders CONCLUSIONS: These findings suggest that deregulation of serum miR-181c-5p may indicate cerebral vulnerability in late life. +other 31700619 hsa-mir-181c Hypoxia, Brain BACKGROUND: Previous studies have shown that expression levels of miR-181c are downregulated by amyloid-beta (Abeta) deposition and chronic cerebral hypoperfusion, both factors largely associated with the development of AD. +circulation_biomarker_diagnosis_down 31700619 hsa-mir-181c Alzheimer Disease BACKGROUND: Previous studies have shown that expression levels of miR-181c are downregulated by amyloid-beta (Abeta) deposition and chronic cerebral hypoperfusion, both factors largely associated with the development of AD. Based on this evidence, we have here investigated potential associations between serum levels of miR-181c-5p and these AD signatures in asymptomatic elderly subjects. +other 31700619 hsa-mir-181c Cognition Disorders No significant associations were found between lower miR-181c-5p levels and cognitive deficits or cortical thinning. +genetics_overexpression_suppress 31700158 hsa-mir-146a Cystic Fibrosis As miR-146a dysregulation has been reported in several human inflammatory diseases, we analysed the impact of increased miR-146a expression on inflammatory responses of CF macrophages. These data show that inhibition of miR-146a in lipopolysaccharide-stimulated CF macrophages results in increased interleukin-6 production, which suggests that miR-146a overexpression in CF is functional, to restrict inflammatory responses. +lncRNA target 31700026 hsa-mir-876 Carcinoma, Hepatocellular And in vivo experiments determined that PITPNA-AS1 regulated HCC progression in vivo via miR +circulation_biomarker_diagnosis_ns 31700002 hsa-mir-194 Hepatopulmonary Syndrome Additionally, high levels of miR-194 were found in serum exosomes and were positively correlated with P(A-a)O(2) in HPS patients and rats. Thus, our results highlight that the exosome/miR-194 axis plays a critical pathologic role in pulmonary angiogenesis, representing a new therapeutic target for HPS. +circulation_biomarker_diagnosis_ns 31699948 hsa-mir-21 Osteoporosis This study aimed to determine the role of serum miR-21 expression, concentration of RANKL, OPG, TGF-beta1, sclerostin and serum calcium, RANKL/OPG ratio, and physical activity on bone mineral density of spine in hypoestrogenic postmenopausal women with osteoporosis (PMOP) compared with no osteoporosis (PMNOP), with point of interest on the expression of serum miR-21. +lncRNA target 31699367 hsa-mir-4731 Glioma Altogether, our research demonstrates that the FLVCR1-AS1/miR5p/E2F2 axis is a novel signaling in glioma and may be a potential target for tumor therapy. +genetics_overexpression_promote 31699187 hsa-mir-133b Cardiomyopathies Objective To investigate the effect of microRNA-133b(miR-133b)on cardiac fibrosis and its mechanism.Methods Human cardiac fibroblasts(CFs)were harvested.The proliferation of CFs was detected by CCK8 during the overexpression and knock-down of miR-133b.The expressions of connective tissue growth factor(CTGF),alpha-smooth muscle actin(alpha-SMA),collagen ,and collagen were detected with qRT-PCR and Western blot analysis after miR-133b overexpression or downexpression.Target genes of miR-133b were predicted by bioinformatics software.Dual-luciferase activity assay were used to verify a target gene of miR-133b.Results qRT-PCR showed that the expression level of miR-133b in the miR-133b mimic group was significantly higher than that in the negative control group(t=26.219,P=0.000).The expression level of miR-133b in the miR-133b inhibitor group was significantly lower than that in the negative control group(t=6.738,P=0.003).After 21,45,69,93,and 117 hours of transfection,the proliferation ability of CFs significantly decreased in the miR-133b mimic group but significantly increased in the miR-133b group(all P<0.05,compared with the negative control group).After overexpression of miR-133b,the mRNA and protein levels of CTGF(t=9.213,P=0.001;t=8.195,P=0.001),alpha-SMA(t= =0.003;t=4.434,P=0.011),collagen(t=3.172,P=0.034;t collagen (t=6.404,P=0.003;t=5.319,P=0.006)were significantly down-regulated.After the expression of miR-133b was knocked down,the mRNA and protein levels of CTGF(t=9.439,P=0.001;t=14.100,P=0.000),alpha-SMA(t (t=5.966,P=0.004;t=5.514,P=0.005)and collagen (t=4.622,P=0.010;t=4.996,P=0.008)were significantly increased.The relative luciferase activity of the cells co-transfected with miR-133b mimic and WT 3'UTR expression vector was significantly lower than that of the cells co-transfected with mimic control and WT 3'UTR expression vectors(t=5.654,P=0.005);however,there was no significant difference in relative luciferase activity between cells co-transfected with miR-133b mimic and MUT 3'UTR expression vectors and cells co-transfected with mimic control and MUT 3'UTR expression vectors(t=0.380,P=0.724).Conclusion miR-133b may affect the activation and proliferation of CFs by targeting CTGF and thus improve cardiac fibrosis. +genetics_knock down_suppress 31699186 hsa-mir-145 Ovarian Neoplasms Objective To evaluate the effect of miR-145 on migration and invasion of ovarian cancer cells.Methods The effect of miR-145 overexpression on the expression levels of miR-145 and zeb-2 were detected with qRT-PCR and Western blotting.The changes of in vitro migration and invasion were examined using Transwell assay.Target genes of miR-145 were predicted by bioinformatics software.Dual-luciferase reporter assay were used to verify zeb-2 as a direct target of miR-145.zeb-2 siRNA was transiently transfected in SKOV3 and 3AO cells,Transwell was used to examine in vitro migration and invasion abilities.Results The migration and proliferation of SKOV3(t=10.752,P=0.000;t=5.617,P=0.005)and 3AO cells(t=10.111,P=0.001;t=21.746,P=0.000)decreased significantly after overexpression of miR-145.The results of dual-luciferase reporter assay showed that the relative luciferase activity of co-transfected miR-145 mimic and WT 3'UTR expression vectors was significantly lower than that of co-transfected mimic control and WT 3'UTR expression vectors(SKOV3:t=4.572,P=0.010;3AO:t=3.528,P=0.024) was no significant difference in relative luciferase activity between co-transfected miR-145 mimic/MUT 3'UTR expression vector cells and co-transfected mimic control/MUT 3'UTR expression vector cells(SKOV3:t=0.227,P=0.831;3AO:t=0.040,P=0.970).R quantitative PCR showed that the zeb-2 expressions in SKOV3(t=1.490,P=0.211)and 3AO cells(t=0.114,P=0.914)were not significantly different from negative control after 48 h of miR-145 overexpression.Western blot analysis showed that the expression of zeb-2 protein in SKOV3(t=3.769,P=0.020)and 3AO cells(t=4.452,P=0.011)decreased significantly compared with negative control after 72 h of miR-145 overexpression.Seventy-two hours after transfection of zeb-2 siRNA,Western blotting showed that the expression of zeb-2 protein in SKOV3(t=4.660,P=0.010)and 3AO cells(t=4.594,P=0.010)was significantly down-regulated.Transwell assay showed that the migration and invasion abilities of SKOV3(t=18.655,P=0.000;t=18.026,P=0.000)and 3AO cells(t=5.500,P=0.005;t=8.780,P=0.001)were significantly decreased.Conclusion miR-145 may inhibit the migration and invasion of ovarian cancer cells by targeting zeb-2. +other 31698874 hsa-mir-144 Alzheimer Disease RESULTS: The analysis of the exploration cohort provided the total of 11 miRNAs that were altered during ACR, the three of which (miR-144, miR-589 and miR-182) were further validated in the validation cohort. +other 31698874 hsa-mir-182 Alzheimer Disease RESULTS: The analysis of the exploration cohort provided the total of 11 miRNAs that were altered during ACR, the three of which (miR-144, miR-589 and miR-182) were further validated in the validation cohort. +genetics_overexpression_promote 31698596 hsa-mir-125a Breast Neoplasms Methods: qRT-PCR was used to detect the expression of miR-125a-5p in normal mammary epithelial cells and breast cancer cell lines; The miR-125a-5p overexpression plasmid was transiently transfected into MDA-MB-157 cells, and the proliferation, invasion and apoptosis of breast cancer cells were detected by CCK8 kit, Transwell chamber and flow cytometry, respectively; Gene silencing was used to knock down GAB2 gene in MDA-MB-157 cells, and the changes of proliferation, invasion, apoptosis and apoptosis-related proteins in breast cancer cells were detected by CCK8 kit, Transwell chamber, flow cytometry and western blot, respectively; The direct interaction between miR-125a-5p and GAB2 was detected by dual-luciferase reporter assay. +exosome 31698453 hsa-mir-10a Multiple Myeloma EV-encapsulated miR-10a expression was high while intracellular miR-10a was low in MM-BMSCs. +lncRNA target 31698307 hsa-mir-495 Leukemia, Myeloid, Acute Mechanistically, we confirm that MIAT can function as a sponge to inhibit microRNA-495 (miR-495), a tumor suppressor, in AML cells. Collectively, our results demonstrate that MIAT is involved in promoting the progression of AML, at least partly, through negative regulation of miR-495, and therefore provide a promising target for treatment of AML. +genetics_knock down_promote 31698040 hsa-mir-29c Respiratory Sounds Furthermore, additional inhibition of miR-29c markedly suppressed the effects of circ_016719 knockdown; however, that suppression was significantly attenuated by Map2k6 overexpression. +genetics_knock down_suppress 31698040 hsa-mir-29c familial febrile seizures 1 In HT22cells, circ_016719 knockdown significantly increased miR-29c expression and cell proliferation, but decreased Map2k6 expression and cell apoptosis. +other 31697978 hsa-mir-182 Adenocarcinoma of Lung 5p/GLI2 axis in carcinogenesis and cisplatin resistance of lung adenocarcinoma (LADC). +lncRNA target 31697952 hsa-mir-26a Colonic Neoplasms Notably, miR-26a-5p inhibitor reversed the promotion of Cc caused by sh-TUG1. +lncRNA target 31697569 hsa-mir-214 Pulmonary Fibrosis FENDRR reduced pulmonary fibrosis by inhibiting fibroblast activation by reducing iron concentration and acting as a competing endogenous RNA of the profibrotic microRNA-214. +transcription factor target 31696995 hsa-mir-155 Precursor Cell Lymphoblastic Leukemia-Lymphoma We conclude that miR-155 is a critical miRNA that is considered a therapeutic target in pediatric HCV leukemic patients. +other 31696971 hsa-let-7b Carcinoma, Hepatocellular For the detailed mechanism, SNHG16 was demonstrated to act as a let-7b-5p sponge in HCC. SNHG16 facilitated the G2/M cell cycle transition by directly acting on the let-7b-5p/CDC25B/CDK1 axis, and promoted cell metastasis and EMT progression by regulating the let-7b-5p/HMGA2 axis in HCC. +other 31696556 hsa-mir-125a Sepsis CONCLUSION: MiR-125b but not miR-125a is upregulated and exhibits a trend to correlate with enhanced disease severity, inflammation, and increased mortality in sepsis patients. +genetics_overexpression_suppress 31696490 hsa-mir-378 Pulmonary Disease, Chronic Obstructive Finally, CSE-treated HBE cells were co-overexpressed with microRNA-378 and TNF-alpha to elucidate whether microRNA-378 exerted its function in regulating the development of COPD through targeting TNF-alpha. CONCLUSIONS: MicroRNA-378 inhibits the inflammatory response by targeting TNF-alpha, which may be a potential therapeutic target for COPD. +genetics_overexpression_promote 31696489 hsa-mir-1 Stomach Neoplasms Functionally, overexpression of miR +genetics_knock down_promote 31696488 hsa-mir-106 Nervous System Diseases 3p knockdown relative to controls. +genetics_knock down_promote 31696487 hsa-mir-92a Melanoma Western blot results elucidated that microRNA-92a knockdown in CMM cells upregulates FOXP1 expression. +lncRNA target 31696486 hsa-mir-223 Neuroblastoma 3p suppressed FOXO1 expression to promote NB progression, targeting miR +other 31696485 hsa-mir-338 Neuroblastoma CONCLUSIONS: SNHG1 conduced to tumorigenesis and mechanism by upregulating PLK4 and by acting as miR3p sponge in neuroblastoma. +lncRNA target 31696481 hsa-mir-26a Thyroid Cancer, Papillary Western blot analysis revealed that miR-26a exerted its anti-PTC effects via phosphatidylinositol 3-kinase/protein kinase B pathway (PI3K/AKT) and epithelial-to-mesenchymal transition (EMT). +transcription factor target 31696480 hsa-mir-101 Breast Neoplasms CONCLUSIONS: The results of this study imply that miR-101 can inhibit the expression of Nrf2 to suppress the proliferation of breast cancer cells and enhance their sensitivity to oxidative stress, which provides a theoretical basis for reversal of tumor resistance. +genetics_knock down_suppress 31696479 hsa-mir-424 Carcinoma, Non-Small-Cell Lung In addition, a recovery experiment indicated that overexpression of ITGB1 could counteract the effect of microRNA +genetics_overexpression_suppress 31696477 hsa-mir-646 Nasopharyngeal Carcinoma Overexpression of microRNA-646 inhibited the proliferative potential and cell cycle progression of HONE1 and SUNE1 nasopharyngeal carcinoma cells. +genetics_overexpression_promote 31696473 hsa-mir-181d Stomach Neoplasms Cylindromatosis gene (CYLD) was overexpressed in gastric cancer tissues, which was confirmed to be a target gene of miR-181d in gastric cancer cell line HGC-27. +lncRNA target 31696470 hsa-mir-203 Pancreatic Carcinoma Elevated miR-203 can inhibit the expression of DJ-1, affect the activity of PTEN-PI3K/AKT pathway, inhibit the proliferation of pancreatic cancer cells, induce cell apoptosis, and reduce DDP resistance of pancreatic cancer cells. +lncRNA target 31696469 hsa-mir-361 Carcinoma, Hepatocellular 5p suppressed tumorigenesis of HCC by targeting WT1 and inactivating the WNT/beta-cadherin pathway. +lncRNA target 31696468 hsa-mir-15 Urinary Bladder Neoplasms CONCLUSIONS: We stated that miR-15 suppressed BC cell progression by targeting BMI1 through the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway, which provided a potential target for BC treatment. +genetics_knock down_promote 31696467 hsa-mir-652 Urinary Bladder Neoplasms The knockdown of miR +genetics_knock down_promote 31696464 hsa-mir-155 Uterine Cervical Neoplasms The knockdown of endogenous HPV-16 E6 markedly inhibited the expression of DNMT1; TCF-7 specifically bound to the 3' UTR of miR-155; inhibition of TCF-7 can inhibit invasion and migration of cervical cancer cells; enhanced miR-155 after the inhibition of TCF-7 can promote the invasion and migration of cervical cancer cells; compared with NC group, the tumor volume and weight of TCF +genetics_knock down_promote 31696462 hsa-mir-30 Osteosarcoma 5p knockdown expression model was constructed using lentivirus in OS cell lines U2OS and MG63. +lncRNA target 31696461 hsa-mir-542 Osteosarcoma 3p in OS, providing a theoretical basis and a new therapeutic target for the diagnosis and treatment of OS. +genetics_overexpression_promote 31696457 hsa-mir-100 Spinal Cord Injuries Inflammatory factors were highly elevated in SCI rats and mRNA levels of the TLR4/NF-kappaB pathway and miR-100 were down-regulated, which were ameliorated in SCI rats overexpressing miR-100 in vivo. +lncRNA target 31696241 hsa-mir-802 Acute Lung Injury MiR-802/Peli2 axis may act as intervening targets to manage ARDS. +genetics_knock down_promote 31696057 hsa-mir-139 Carcinoma, Non-Small-Cell Lung Knockdown of AFAP1-AS1 and overexpression of miR +exosome 31696054 hsa-mir-148b Breast Neoplasms Taken together, HUCMSC-derived exosomes carrying miR-148b-3p might suppress breast cancer progression, which highlights the potential of exosomes containing miR-148b-3p as a promising therapeutic approach for breast cancer treatment. +lncRNA target 31695809 hsa-mir-27a Aortic Dissection Conclusion: Treatment with miR-27a activator that targets apoptosis of ECs strongly diminished occurrence of AD, providing a new strategy for this disease. +lncRNA target 31695788 hsa-mir-5188 Carcinoma, Hepatocellular FOXO1/beta-catenin-c-Jun feedback loop was induced by hepatitis X protein (HBX) through Wnt signaling and participated in the HBX-induced pathogenesis of HCC. +other 31695606 hsa-mir-191 Macular Degeneration 5p PBNCs expression were found in AMD patients. +lncRNA target 31695578 hsa-mir-206 Breast Neoplasms CONCLUSIONS: We conclude that UCA1 can up-regulates PTP1B to enhance cell proliferation through sequestering miR-206 in breast cancer. +genetics_knock down_suppress 31695501 hsa-mir-214 Carcinoma, Hepatocellular CONCLUSION: Knockdown of hsa_circ_0008450 inhibits HCC progression by regulating miR3p/EZH2 axis. +transcription factor target 31695492 hsa-mir-19a Carcinoma, Non-Small-Cell Lung Luciferase assays showed that TF was a direct inhibitory target of miR-19a in NSCLC cells. +genetics_knock down_suppress 31695488 hsa-mir-203 Nasopharyngeal Carcinoma The inhibitors of miR-203, miR-31 and miR-451 could reverse the effects of circRPMS1 knockdown on NPC cells. +genetics_knock down_suppress 31695488 hsa-mir-1 Nasopharyngeal Carcinoma The inhibitors of miR-203, miR-31 and miR-451 could reverse the effects of circRPMS1 knockdown on NPC cells. +circulation_biomarker_diagnosis_up 31695460 hsa-mir-22 Diabetes Mellitus, Type 2 Furthermore, miR-22 was downregulated and IL6R was upregulated in both diabetic serum and glucose-induced INS-1E cells. +lncRNA target 31695430 hsa-mir-221 Ovarian Neoplasms CONCLUSION: Overall, this study firstly elucidated that CASC15 could play a tumor-suppressive role in ovarian cancer by the regulation of CASC15/miR-221/ARID1A axis, which may provide a ponderable prognostic biomarker and promising therapeutic target for treatment of patients with ovarian cancer. +transcription factor target 31695428 hsa-mir-16 Carcinoma, Non-Small-Cell Lung TDownstream RGS4 targets (eg, miR-16 and BDNF) might be involved in the development of NSCLC and may serve as potential therapeutic targets for its treatment. +lncRNA target 31695418 hsa-mir-651 Carcinoma, Hepatocellular Therefore, miR-3651 might be a novel therapeutic target for the treatment of HCC. +other 31695413 hsa-mir-149 Stomach Neoplasms CONCLUSION: Our current study revealed the LINC00665/miR3p/RNF2 axis was involved in GC progression, providing novel insights into the treatment for GC. +lncRNA target 31695412 hsa-mir-1271 Ovarian Neoplasms ZEB1 reversed partial roles of miR-1271 on viability and invasion in OC. +genetics_overexpression_promote 31695022 hsa-mir-223 Carcinoma, Hepatocellular We found that the well-defined miR-223 is expressed at low levels in doxorubicin treated HCC cells and that miR-223 overexpression inhibits the doxorubicin-induced autophagy that contributes to chemoresistance. +epigenetics 31694944 hsa-mir-16-2 Inflammatory Bowel Diseases 5p expression via demethylation of the pre-miR +lncRNA target 31694930 hsa-mir-100 Stomach Neoplasms Further data revealed that the transcription factor NME2 could promote the transcriptions of antiapoptotic genes including miRNA (i.e., miR-100) and protein-encoding genes (RIPK1, STARD5, and LIMS1) through interacting with RNA polymerase II and RNA polymerase II-associated protein 2 to mediate the phosphorylation of RNA polymerase II C-terminal domain at the 5th serine, leading to the suppression of apoptosis of gastric cancer cells both in vitro and in vivo. +lncRNA target 31694919 hsa-mir-183 Vesicular Stomatitis We also found that the miR-183 cluster activates the IFN pathway and inhibits vesicular stomatitis virus infection by directly targeting several negative regulators of IRF3 and STAT1 activities, including protein phosphatase 2A (PPP2CA) and tripartite motif-containing 27 (TRIM27). +lncRNA target 31694904 hsa-mir-127 Triple Negative Breast Neoplasms Furthermore, systemic delivery of miR-127(PD) suppressed tumor growth of MDA-MB-231 and MDA-MB-468 TNBC cells and spontaneous metastasis of MDA-MB-231 cells. +transcription factor target 31694721 hsa-mir-873 Corneal dystrophy, epithelial basement membrane STRA6 was confirmed as an miR-873 target, which acted as a tumour suppressor in GC. CONCLUSIONS: STRA6 is down-regulated by miR-873 and plays an oncogenic role by activating Wnt/beta-catenin signalling in GC. +other 31694696 hsa-mir-214 Colorectal Neoplasms The regulatory role of HOTAIR/miR-214/ST6GAL1 axis also impacts CRC procession. CONCLUSION: The HOTAIR/miR-214/ST6GAL1 axis commands the CRC malignancy by modifying c-Met with sialylation and activating JAK2/STAT3 pathway. +genetics_overexpression_promote 31694571 hsa-mir-1 Colorectal Neoplasms For example, UCA1 upregulation in CRC samples occurred in parallel with hsa-miR-1 downregulation, accompanied by c-Met target mRNA overexpression (p < 0.05). +lncRNA target 31694481 hsa-mir-197 Prostatic Neoplasms CONCLUSION: Circular RNA itchy E3 ubiquitin protein ligase upregulation suppresses cell proliferation but promotes apoptosis through targeting micro RNA-197 in prostate cancer. +transcription factor target 31694459 hsa-mir-214 Myocardial Infarction CONCLUSIONS: This study provides the first evidence that MI+CIH upregulates miR3p, suppresses cardiac CTRP9 (C1q tumor necrosis factor-related protein-9) expression, and exacerbates cardiac remodeling, suggesting that CTRP9 may be a novel therapeutic target against pathological remodeling in MI patients with obstructive sleep apnea-hypopnea syndrome. +circulation_biomarker_diagnosis_up 31694408 hsa-mir-34a Atherosclerosis 3p and hsa-miR-34a-5p was upregulated by 4.4 (p = 0.0001) and 3.8 (p = 0.005) -fold in AP patient's blood plasma compared to control subjects. +other 31694408 hsa-mir-24 Atherosclerosis Our data suggest that hsa-miR3p might have an effect on CYP4F2 activity during atherosclerosis. +circulation_biomarker_diagnosis_ns 31694153 hsa-let-7f Aortic Aneurysm, Abdominal Significant levels of circulating let-7f (p = 0.048) were found in AAA patients compared to PAD patients with no significant correlation with aortic diameter (R(2) = 0.03). The results highlight let-7f as a new potential biomarker for AAA. +transcription factor target 31694033 hsa-mir-296 Bone Diseases In conclusion, miR-296 promotes osteoblast differentiation by upregulating Cbfal expression in hFOB 1.19 cells, which may be used as a potential therapeutic target for the treatment of bone diseases in future. +genetics_overexpression_promote 31693935 hsa-mir-145 Colorectal Neoplasms 5p overexpression inhibited tumorigenesis in CRC by downregulating RHBDD1 via suppressing the EGFR-associated signaling pathway (EGFR/Raf/MEK/ERK cascades). +genetics_knock down_promote 31693779 hsa-mir-6838 Triple Negative Breast Neoplasms 5p overexpression-mediated inhibitory effect, and knockdown of WNT3A partially rescued the miR +other 31693774 hsa-mir-146a Sepsis a is of significant diagnostic and prognostic value in pediatric sepsis and could be used for planning therapeutic strategies. +genetics_knock down_promote 31693770 hsa-mir-4286 Prostatic Neoplasms CONCLUSIONS: Our study suggested that miR-4286 overexpression represents a tumor promoter role in PCa. +genetics_overexpression_promote 31693728 hsa-mir-760 Pancreatic Carcinoma At last, rescue experiments validated that up-regulation of ITGB1 remedied the miR-760 overexpression-caused inhibition on biological activities and gemcitabine resistance of PC cells. +lncRNA target 31693489 hsa-mir-1183 Thyroid Neoplasms In conclusion, circ_0005273 functioned as a tumor promoter of PTC via circ_0005273/miR-1183/SOX2 axis, suggesting a novel biomarker and therapeutic target for PTC. +other 31693455 hsa-mir-155 Nasopharyngeal Carcinoma Conclusion: miR-155 expression was upregulated and significantly associated with the expression of LMP-1 and LMP-2, in Vietnamese NPC cases. +other 31693439 hsa-mir-214 Breast Neoplasms Moreover, using an in-house generated gene expression dataset, we experimentally proved that a component of the polycomb-repressive complex 2, the histone methyltransferase enhancer of zeste homolog 2 (EZH2), interacts with miR-214, a well-known prometastatic miR in melanoma and breast cancer, highlighting a miREZH2 regulatory axis potentially relevant in tumor progression. +other 31693439 hsa-mir-214 Melanoma Moreover, using an in-house generated gene expression dataset, we experimentally proved that a component of the polycomb-repressive complex 2, the histone methyltransferase enhancer of zeste homolog 2 (EZH2), interacts with miR-214, a well-known prometastatic miR in melanoma and breast cancer, highlighting a miREZH2 regulatory axis potentially relevant in tumor progression. +lncRNA target 31693400 hsa-mir-214 Syphilis Therefore, the KCNQ1OT1/miR-214/caspase-1 signaling pathway represents a new mechanism of diabetic corneal endothelial keratopathy progression, and KCNQ1OT1 could potentially be a novel therapeutic target. +lncRNA target 31693400 hsa-mir-214 Iridocorneal Endothelial Syndrome Therefore, the KCNQ1OT1/miR-214/caspase-1 signaling pathway represents a new mechanism of diabetic corneal endothelial keratopathy progression, and KCNQ1OT1 could potentially be a novel therapeutic target. +lncRNA target 31693399 hsa-mir-140 Carcinoma, Hepatocellular Therefore, targeting MALAT1 or miR-140 might alleviate the progression of HCC in the future. +circulation_biomarker_diagnosis_ns 31693242 hsa-mir-363 Carcinoma, Hepatocellular CONCLUSION: Current model combining serum miR5p, miR-765, and PIVKA-II has potential significance for diagnosis of AFP-NHCC. +circulation_biomarker_diagnosis_ns 31693242 hsa-mir-765 Carcinoma, Hepatocellular CONCLUSION: Current model combining serum miR5p, miR-765, and PIVKA-II has potential significance for diagnosis of AFP-NHCC. +other 31693229 hsa-mir-144 Colorectal Neoplasms NRAS axis in CRC that could promote the research and treatment of CRC. +lncRNA target 31692912 hsa-mir-127 Carcinoma, Endometrioid Combining with the data of microRNA profiles using microRNA target predicting tools, two significantly dysregulated microRNA-mediated gene expression changes in endometrial adenocarcinoma were identified: downregulated hsa-miR +lncRNA target 31692912 hsa-mir-218 Carcinoma, Endometrioid Combining with the data of microRNA profiles using microRNA target predicting tools, two significantly dysregulated microRNA-mediated gene expression changes in endometrial adenocarcinoma were identified: downregulated hsa-miR +lncRNA target 31692905 hsa-mir-26b Squamous Cell Carcinoma of Head and Neck Additionally, we found enriched gene networks possibly be regulated by tumor suppressor miRNAs such as hsa-miR-29/a/b/c, hsa-miR-26b-5p etc., suggestive to be key riboswitches in regulatory cascade of HNSCC. +lncRNA target 31692905 hsa-mir-29 Squamous Cell Carcinoma of Head and Neck Additionally, we found enriched gene networks possibly be regulated by tumor suppressor miRNAs such as hsa-miR-29/a/b/c, hsa-miR-26b-5p etc., suggestive to be key riboswitches in regulatory cascade of HNSCC. +transcription factor target 31692593 hsa-mir-29a Uterine Cervical Neoplasms CONCLUSION: miR-29a suppressed migration, invasion and EMT by directly targeting to SIRT1 in cervical cancer. +other 31692513 hsa-mir-21 Thyroid Cancer, Papillary To further support the data, miR-21 expression was tested (by quantitative real-time PCR and in situ hybridization) in a different series of 30 cases (15 PTCs BRAFwt and 15 PTCs BRAFV600E). +genetics_knock down_promote 31692508 hsa-mir-139 Carcinoma, Hepatocellular Knockdown of SNHG3 or BMI1 and overexpression of miR +lncRNA target 31692505 hsa-mir-4665 Stomach Neoplasms 3p was up-regulated by arsenic sulfide and showed inhibition upon the migration and invasion of GC cells. +lncRNA target 31692433 hsa-mir-596 Carcinoma, Hepatocellular METHODS: Expression levels of RHPN1-AS1 and miR-596 in HCC samples were measured by qRT-PCR. CONCLUSION: RHPN1-AS1 acts as a sponge of tumor suppressor miR-596 in HCC that can indirectly enhance the IGF2BP2 expression and function as an oncogenic lncRNA. +other 31692368 hsa-mir-196a-2 Coronary Artery Disease However, further studies are needed to validate the potential associations of miR-196a2 rs11614913 locus with CAD. +genetics_knock down_promote 31692094 hsa-mir-150 Carcinoma, Non-Small-Cell Lung To summarize, we, for the first time, demonstrated the inhibitory effects of ZFAS1 knockdown on NSCLC cell progression, and the results from mechanistic studies indicated that ZFAS1-mediated NSCLC progression cells via targeting miR +lncRNA target 31692066 hsa-mir-556 Meningioma 5p/TCF12 axis promoted cell proliferation and suppressed cell apoptosis in meningioma via activating the Wnt signaling pathway. +lncRNA target 31692053 hsa-mir-378a Triple Negative Breast Neoplasms Moreover, the miR-378a-5p target of SUFU could promote lncRNA GAS5-induced apoptosis of TNBC cells. CONCLUSION: The above results confirmed that lncRNA GAS5 could induce apoptosis in TNBC cells by targeting miR-378a-5p/SUFU signaling. +lncRNA target 31692053 hsa-mir-378 Triple Negative Breast Neoplasms Moreover, the miR-378a-5p target of SUFU could promote lncRNA GAS5-induced apoptosis of TNBC cells. CONCLUSION: The above results confirmed that lncRNA GAS5 could induce apoptosis in TNBC cells by targeting miR-378a-5p/SUFU signaling. +lncRNA target 31692050 hsa-mir-211 Carcinoma, Endometrioid Notably, based on this network, it was found that LINC00261-hsa-mir-31 pair and LINC00261-hsa-mir-211 target pairs could be used as the potential prognostic markers of EC. +lncRNA target 31692050 hsa-mir-1 Carcinoma, Endometrioid Notably, based on this network, it was found that LINC00261-hsa-mir-31 pair and LINC00261-hsa-mir-211 target pairs could be used as the potential prognostic markers of EC. +lncRNA target 31692045 hsa-mir-130a Thyroid Cancer, Papillary This study highlights that miR-130a and miR-203 have satisfactory diagnostic value in PTC and upregulated miR-130a and miR-203 can inhibit PTC cell growth and promote cell apoptosis. +lncRNA target 31692045 hsa-mir-203 Thyroid Cancer, Papillary This study highlights that miR-130a and miR-203 have satisfactory diagnostic value in PTC and upregulated miR-130a and miR-203 can inhibit PTC cell growth and promote cell apoptosis. +lncRNA target 31692045 hsa-mir-130 Thyroid Cancer, Papillary This study highlights that miR-130a and miR-203 have satisfactory diagnostic value in PTC and upregulated miR-130a and miR-203 can inhibit PTC cell growth and promote cell apoptosis. +lncRNA target 31692034 hsa-mir-92b Colorectal Neoplasms Furthermore, mechanistic studies revealed that miR-92b-3p could rescue the CRC progress induced by SNHG14. Consequently, SNHG14 exhibited low expression in CRC tissues and involved in CRC progression and metastasis by competing for miR-92b-3p, and SNHG14 could be used as a valuable biomarker and therapeutic target for CRC. +lncRNA target 31692033 hsa-mir-423 Thyroid Cancer, Papillary 5p/SOX12 to promote proliferation and invasion of PTC, indicating NR2F1-AS1 as a potential novel target for the molecular-targeted therapy of PTC. +other 31691877 hsa-mir-23a Neurodegenerative Diseases TaqMan RT-PCR data showed that miR-23a upregulation was associated with an ongoing neurodegenerative process, similar to miR-22* and miR-29a, while let-7d, miR-15b, miR-24, miR3p, miR-181c, and miR-222 showed an altered expression in Parkinson-like phenotypes, as well as miR-34b, miR-125b, and miR-130b in Alzheimer-like disorders. +other 31691877 hsa-mir-142 Neurodegenerative Diseases TaqMan RT-PCR data showed that miR-23a upregulation was associated with an ongoing neurodegenerative process, similar to miR-22* and miR-29a, while let-7d, miR-15b, miR-24, miR3p, miR-181c, and miR-222 showed an altered expression in Parkinson-like phenotypes, as well as miR-34b, miR-125b, and miR-130b in Alzheimer-like disorders. +other 31691877 hsa-mir-34b Neurodegenerative Diseases TaqMan RT-PCR data showed that miR-23a upregulation was associated with an ongoing neurodegenerative process, similar to miR-22* and miR-29a, while let-7d, miR-15b, miR-24, miR3p, miR-181c, and miR-222 showed an altered expression in Parkinson-like phenotypes, as well as miR-34b, miR-125b, and miR-130b in Alzheimer-like disorders. +other 31691877 hsa-mir-24 Neurodegenerative Diseases TaqMan RT-PCR data showed that miR-23a upregulation was associated with an ongoing neurodegenerative process, similar to miR-22* and miR-29a, while let-7d, miR-15b, miR-24, miR3p, miR-181c, and miR-222 showed an altered expression in Parkinson-like phenotypes, as well as miR-34b, miR-125b, and miR-130b in Alzheimer-like disorders. +other 31691877 hsa-mir-29a Neurodegenerative Diseases TaqMan RT-PCR data showed that miR-23a upregulation was associated with an ongoing neurodegenerative process, similar to miR-22* and miR-29a, while let-7d, miR-15b, miR-24, miR3p, miR-181c, and miR-222 showed an altered expression in Parkinson-like phenotypes, as well as miR-34b, miR-125b, and miR-130b in Alzheimer-like disorders. +other 31691877 hsa-mir-181c Neurodegenerative Diseases TaqMan RT-PCR data showed that miR-23a upregulation was associated with an ongoing neurodegenerative process, similar to miR-22* and miR-29a, while let-7d, miR-15b, miR-24, miR3p, miR-181c, and miR-222 showed an altered expression in Parkinson-like phenotypes, as well as miR-34b, miR-125b, and miR-130b in Alzheimer-like disorders. +other 31691877 hsa-mir-22 Neurodegenerative Diseases TaqMan RT-PCR data showed that miR-23a upregulation was associated with an ongoing neurodegenerative process, similar to miR-22* and miR-29a, while let-7d, miR-15b, miR-24, miR3p, miR-181c, and miR-222 showed an altered expression in Parkinson-like phenotypes, as well as miR-34b, miR-125b, and miR-130b in Alzheimer-like disorders. +other 31691877 hsa-mir-130b Neurodegenerative Diseases TaqMan RT-PCR data showed that miR-23a upregulation was associated with an ongoing neurodegenerative process, similar to miR-22* and miR-29a, while let-7d, miR-15b, miR-24, miR3p, miR-181c, and miR-222 showed an altered expression in Parkinson-like phenotypes, as well as miR-34b, miR-125b, and miR-130b in Alzheimer-like disorders. +other 31691877 hsa-mir-15b Neurodegenerative Diseases TaqMan RT-PCR data showed that miR-23a upregulation was associated with an ongoing neurodegenerative process, similar to miR-22* and miR-29a, while let-7d, miR-15b, miR-24, miR3p, miR-181c, and miR-222 showed an altered expression in Parkinson-like phenotypes, as well as miR-34b, miR-125b, and miR-130b in Alzheimer-like disorders. +other 31691877 hsa-mir-125b Neurodegenerative Diseases TaqMan RT-PCR data showed that miR-23a upregulation was associated with an ongoing neurodegenerative process, similar to miR-22* and miR-29a, while let-7d, miR-15b, miR-24, miR3p, miR-181c, and miR-222 showed an altered expression in Parkinson-like phenotypes, as well as miR-34b, miR-125b, and miR-130b in Alzheimer-like disorders. +other 31691877 hsa-let-7d Neurodegenerative Diseases TaqMan RT-PCR data showed that miR-23a upregulation was associated with an ongoing neurodegenerative process, similar to miR-22* and miR-29a, while let-7d, miR-15b, miR-24, miR3p, miR-181c, and miR-222 showed an altered expression in Parkinson-like phenotypes, as well as miR-34b, miR-125b, and miR-130b in Alzheimer-like disorders. +other 31691877 hsa-mir-222 Neurodegenerative Diseases TaqMan RT-PCR data showed that miR-23a upregulation was associated with an ongoing neurodegenerative process, similar to miR-22* and miR-29a, while let-7d, miR-15b, miR-24, miR3p, miR-181c, and miR-222 showed an altered expression in Parkinson-like phenotypes, as well as miR-34b, miR-125b, and miR-130b in Alzheimer-like disorders. +genetics_GWAS 31691635 hsa-mir-145 Conotruncal cardiac defects Conclusion: Our results indicated that SNP rs4705343 in miR-143/145 is a potential genetic marker for CTDs in the Chinese Han population. +genetics_GWAS 31691635 hsa-mir-143 Conotruncal cardiac defects Conclusion: Our results indicated that SNP rs4705343 in miR-143/145 is a potential genetic marker for CTDs in the Chinese Han population. +transcription factor target 31691589 hsa-mir-20a Bulimia Nervosa Recently, the oncogenic miR-20a was found to mediate immune escape through repressing MICA/B levels in breast cancer (BC) cells. +transcription factor target 31691589 hsa-mir-20a Breast Neoplasms Recently, the oncogenic miR-20a was found to mediate immune escape through repressing MICA/B levels in breast cancer (BC) cells. +transcription factor target 31691506 hsa-mir-222 Diabetes Mellitus, Type 2 miR-222 is a key regulator that is promoted in STZ-induced diabetic rats, and it binds to TIMP3 to reduce TIMP-3 expression and suppressed MSCs' differentiation. +genetics_GWAS 31691380 hsa-mir-223 Leukemia, Myeloid, Acute RESULTS: The results revealed that serum miR-223 was underexpressed in AML patients, particularly those in intermediate and unfavorable cytogenetic risk groups. +lncRNA target 31691355 hsa-mir-625 Uterine Cervical Neoplasms Collectively, LINC00958 facilitates CC cell proliferation and metastasis via the miR +lncRNA target 31691157 hsa-mir-1244 Ovarian Neoplasms Inhibition of miR-1244 diminished the effects of LINC00504 on OC cells. Our study shows that LINC00504 promotes OC cell progression and stimulates aerobic glycolysis by interacting with miR-1244, which indicates that LINC00504 might act as a promising therapeutic target for OC treatment. +genetics_GWAS 31689804 hsa-mir-21 Dmd-Associated Dilated Cardiomyopathy Genomic DNA was extracted to analyze the TPM1 gene rs12148828, rs11558748, rs707602, rs6738, rs7178040 loci genotypes, and the plasma miR-21 level was analyzed by reverse transcription-PCR (RT-PCR).The risk of DCM development in the rs6738 locus G allele carriers were 1.69 times more than A allele carriers (95% CI: 1.22-2.33, P = .001). The plasma miR-21 level of TPM1 gene rs6738 locus AA carriers was significantly higher than that of the AG and GG genotypes (P < .001).The SNPs of TPM1 gene rs6738 locus is associated with the risk of DCM, which may be related to the abnormal increase of miR-21 level in DCM patients, but further research is needed to prove the causal relationship between miR-21 level and DCM risk. +genetics_GWAS 31689753 hsa-mir-124 Diabetes Mellitus, Type 2 The meta-analysis indicated that the G allele or GG genotype of miR-146a rs2910164 was associated with a significantly increased risk for DM compared with C allele or GC/CC genotype in Latin American population; CC genotype of miR-27a rs895819 polymorphism was associated with a significantly decreased risk for DM in Asian population compared with the TT genotype; patients carrying with CC genotype of miR-124 rs531564 had a lower probability to develop DM regardless of ethnicity; no associations were identified between polymorphisms in miR-375, miR-128a, miR-194a and the susceptibility to DM. CONCLUSION: Our study suggests that miR-146a/miR-27a and miR-124 polymorphisms may be ethnicity-dependent or -independent susceptibility factors to DM, respectively. +genetics_GWAS 31689753 hsa-mir-27a Diabetes Mellitus, Type 2 The meta-analysis indicated that the G allele or GG genotype of miR-146a rs2910164 was associated with a significantly increased risk for DM compared with C allele or GC/CC genotype in Latin American population; CC genotype of miR-27a rs895819 polymorphism was associated with a significantly decreased risk for DM in Asian population compared with the TT genotype; patients carrying with CC genotype of miR-124 rs531564 had a lower probability to develop DM regardless of ethnicity; no associations were identified between polymorphisms in miR-375, miR-128a, miR-194a and the susceptibility to DM. CONCLUSION: Our study suggests that miR-146a/miR-27a and miR-124 polymorphisms may be ethnicity-dependent or -independent susceptibility factors to DM, respectively. +genetics_GWAS 31689753 hsa-mir-146a Diabetes Mellitus, Type 2 The meta-analysis indicated that the G allele or GG genotype of miR-146a rs2910164 was associated with a significantly increased risk for DM compared with C allele or GC/CC genotype in Latin American population; CC genotype of miR-27a rs895819 polymorphism was associated with a significantly decreased risk for DM in Asian population compared with the TT genotype; patients carrying with CC genotype of miR-124 rs531564 had a lower probability to develop DM regardless of ethnicity; no associations were identified between polymorphisms in miR-375, miR-128a, miR-194a and the susceptibility to DM. CONCLUSION: Our study suggests that miR-146a/miR-27a and miR-124 polymorphisms may be ethnicity-dependent or -independent susceptibility factors to DM, respectively. +genetics_overexpression_promote 31689617 hsa-mir-134 Adenocarcinoma of Lung 5p or overexpression of DAB2 strongly suppressed LUAD cell metastasis and overcame the insensitivity of chemoresistant LUAD cells to chemotherapy. +other 31689616 hsa-mir-197 Stomach Neoplasms hsa_circ_0092306 promoted the development of GC by regulating the pathway of miR3p/PRKCB in MKN-45 cells. +lncRNA target 31689123 hsa-mir-203a Diabetic Retinopathy Quantitative real-time PCR (qRT-PCR) and Western blot results showed that MALAT1, VEGFA, and HIF-1alpha levels were increased in DR retinal tissues and HG-stimulated HRMECs, whereas the expression of miR-203a-3p was decreased. In conclusion, these data demonstrated that MALAT1 may affect angiogenesis by sponging miR-203a-3p in DR, suggesting that MALAT1 may act as a novel therapeutic target for the treatment of DR. +lncRNA target 31689123 hsa-mir-203a Retinal Diseases Quantitative real-time PCR (qRT-PCR) and Western blot results showed that MALAT1, VEGFA, and HIF-1alpha levels were increased in DR retinal tissues and HG-stimulated HRMECs, whereas the expression of miR-203a-3p was decreased. In conclusion, these data demonstrated that MALAT1 may affect angiogenesis by sponging miR-203a-3p in DR, suggesting that MALAT1 may act as a novel therapeutic target for the treatment of DR. +genetics_overexpression_promote 31688991 hsa-mir-425 Breast Neoplasms Overexpression of miR +lncRNA target 31687670 hsa-mir-125a Lung Neoplasms In this work, target miRNA (miRNA)-mediated catalytic hairpin assembly (CHA)-induced gold nanocage (GNC)-hairpin DNA1 (hpDNA1)-hpDNA2-GNC nanostructures were designed for surface-enhanced Raman scattering (SERS) detection and imaging of the specific miR-125a-5p in the normal lung epithelial cell line (BEAS-2B cells) and lung cancer cell line (A549 cells). +other 31687318 hsa-mir-19a Diabetes, Gestational MicroRNA-19a and 19b have been linked to alcoholism and smoking and could also be the factors in GDM. +other 31687318 hsa-mir-19b Diabetes, Gestational MicroRNA-19a and 19b have been linked to alcoholism and smoking and could also be the factors in GDM. +other 31687076 hsa-mir-212 Melanoma In addition, NRF1 and NRF2 mRNA and miR-23B, miR-93, miR-144, miR-212, miR-340, miR-383, and miR-510 levels were analysed with real-time qPCR from 54 paraffin-embedded naevi and melanoma samples. +other 31687076 hsa-mir-510 Melanoma In addition, NRF1 and NRF2 mRNA and miR-23B, miR-93, miR-144, miR-212, miR-340, miR-383, and miR-510 levels were analysed with real-time qPCR from 54 paraffin-embedded naevi and melanoma samples. +other 31687076 hsa-mir-93 Melanoma In addition, NRF1 and NRF2 mRNA and miR-23B, miR-93, miR-144, miR-212, miR-340, miR-383, and miR-510 levels were analysed with real-time qPCR from 54 paraffin-embedded naevi and melanoma samples. +other 31687076 hsa-mir-23b Melanoma In addition, NRF1 and NRF2 mRNA and miR-23B, miR-93, miR-144, miR-212, miR-340, miR-383, and miR-510 levels were analysed with real-time qPCR from 54 paraffin-embedded naevi and melanoma samples. +other 31687076 hsa-mir-144 Melanoma In addition, NRF1 and NRF2 mRNA and miR-23B, miR-93, miR-144, miR-212, miR-340, miR-383, and miR-510 levels were analysed with real-time qPCR from 54 paraffin-embedded naevi and melanoma samples. +genetics_GWAS 31686915 hsa-mir-34a Osteosarcoma CONCLUSION: The findings suggested that ISOV-mediated epigenetic regulation involved the DNMT1/miR-34a/Bcl-2 axis and caused the suppression of stemness and induction of apoptosis in the spheres derived from OS cells. +transcription factor target 31686859 hsa-mir-92b Esophageal Squamous Cell Carcinoma By this procedure, miR-92b-3p was identified as an ESCC-promoting gene by target KLF4 and DCS2. +transcription factor target 31686855 hsa-mir-26b Carcinoma, Non-Small-Cell Lung CONCLUSION: Restoration of miR-26b expression partially reverses the cisplatin resistance of NSCLC by targeting TAZ. +genetics_overexpression_promote 31686849 hsa-mir-449a Lung Neoplasms CONCLUSION: Our data supported that miR-449a overexpression inhibited LC cell growth, and ultrasound-MB-mediated miR-449a reinforced the repressive effects of miR-449a on LC progression. +genetics_overexpression_promote 31686846 hsa-mir-622 Glioma Finally, our findings demonstrated that miR-622 overexpression remarkably suppressed glioma cell proliferation, migration and invasion, while facilitated apoptosis by suppressing ZEB2 in vitro. +genetics_overexpression_promote 31686843 hsa-mir-671 Colonic Neoplasms 5p overexpression significantly increased cell proliferation, migration, and invasion, while downregulation of miR +transcription factor target 31686840 hsa-mir-596 Osteosarcoma CONCLUSION: miR-596 targets Survivin and enhances the antitumor effect of anlotinib on OSA cells. +lncRNA target 31686839 hsa-mir-940 Uterine Cervical Neoplasms In this study, we determined the mechanism of miR-940 inhibiting cell proliferation and cycle procession, and promoting cell apoptosis in cervical cancer Hela cells. CONCLUSION: It provides evidence that miR-940 could be a wonderful biomarker and treatment agent for cervical cancer, and microbubble ultrasound would have more wide application in the clinical treatment of cancers. +genetics_overexpression_promote 31686837 hsa-mir-216b Colorectal Neoplasms In cells of CRA cell lines, DSCAM-AS1 overexpression resulted in the downregulation of miR-216b, while miR-216b overexpression did not significantly affect DSCAM-AS1. CONCLUSION: DSCAM-AS1 may downregulate miR-216b to promote the migration and invasion of CRA cells. +lncRNA target 31686834 hsa-mir-20b Adenocarcinoma of Lung Furthermore, we elucidated that linc00467 promoted CCND1 expression in lung cancer cells via functioning as a molecular sponge for miR-20b-5p. CONCLUSION: Linc00467/miR-20b-5p/CCND1 signaling pathway may provide new insights into lung cancer treatment. +lncRNA target 31686763 hsa-mir-494 Pancreatic Carcinoma CONCLUSION: Our results revealed that upregulated IGF2BP1 promotes the proliferation of pancreatic cancer cells via the AKT signaling pathway and confirmed that the activation of IGF2BP1 is partly due to the silencing of miR-494. +lncRNA target 31686732 hsa-mir-126 Breast Neoplasms Among various miRNAs, miR-126 has been proposed to have a tumor suppressive role in HER2 positive cancer. +transcription factor target 31686651 hsa-mir-127 Muscular Dystrophy, Duchenne One of these miRNAs miR-127 inhibits the translation of the Rtl1 sense transcript, that encodes the retrotransposon-like one protein (RTL1), which is also required for muscle regeneration and is expressed in regenerating/dystrophic muscle. +virus_miRNA 31686644 hbv-mir-3 HBV-related Hepatocellular Carcinoma HBV-miR-3 silenced PPM1A by inhibiting the translation process of PPM1A. The downregulation of PPM1A promotes cell proliferation related to HCC development. +genetics_knock down_promote 31686523 hsa-mir-186 Carcinoma, Non-Small-Cell Lung Similarly, SIX1 knockdown could also suppress DDP resistant NSCLC cell proliferation, migration and invasion, and promote apoptosis rate, which was reversed by miR +lncRNA target 31686521 hsa-mir-671 Carcinoma, Renal Cell 5p directly targeted APC to activate Wnt signaling, thus inducing the epithelial-mesenchymal transition (EMT) in ccRCC. +lncRNA target 31686458 hsa-mir-21 Hypoxia-Ischemia, Brain CONCLUSION: This study confirmed the protective effect of ADMSCs against ischemic brain injury exerted by suppressing miR3p level and up-regulating MAT2B level. +tissue_expression_up 31686119 hsa-mir-183 Ehlers-Danlos Syndrome TBX5 deficiency in cardiomyocytes increased the expression of the miR-183 cluster family that is controlled by Kruppel-like factor 4, a transcription factor repressed by TBX5. +other 31686119 hsa-mir-182 Heart Defects, Congenital Moreover, cardiac-specific down-regulation of miR5p rescued cardiac defects in a zebrafish model of Holt-Oram syndrome. +other 31686119 hsa-mir-182 Holt-Oram syndrome Moreover, cardiac-specific down-regulation of miR5p rescued cardiac defects in a zebrafish model of Holt-Oram syndrome. +lncRNA target 31685802 hsa-mir-711 Spinal Cord Injuries Together, our data suggest that post-traumatic miR-711 elevation contributes to neuronal cell death after SCI, in part by inhibiting Ang-1 and Akt pathways, and may serve as a novel therapeutic target. +exosome 31685437 hsa-mir-1470 Asthma Here, we show that MSCs exosomal miR-1470 can elevate the proportion of CD4(+)CD25(+)FOXP3(+) regulatory T cells (Tregs) in asthmatic patients. +lncRNA target 31685299 hsa-mir-425 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: Taken together, miR-425 could promote the proliferation, invasion and suppress apoptosis by targeting AMPH-1 in NSCLC cells. +other 31685236 hsa-mir-6840 Alzheimer Disease Although, overall, we did not identify a strong effect of AD GWAS variants on miRNA expression in this cell type, we highlight 2 notable outliers, that is, miR-29c-5p and miR5p. +other 31685236 hsa-mir-29c Alzheimer Disease Although, overall, we did not identify a strong effect of AD GWAS variants on miRNA expression in this cell type, we highlight 2 notable outliers, that is, miR-29c-5p and miR5p. +transcription factor target 31684723 hsa-mir-34a Breast Neoplasms In addition, the released miR-34a subsequently downregulates Bcl-2, cyclin D1, CDK6, and Bax expression and inhibits proliferation and migration of MDA-MB-231 breast cancer cells. +lncRNA target 31683462 hsa-mir-1275 Breast Neoplasms Further, SOX7, a target of miR-1275, strengthened the effect of HAND2-AS1 in breast cancer. +other 31683458 hsa-mir-125a Carcinoma, Non-Small-Cell Lung We demonstrated that miR-125a-5p upregulated SIRT7 and further upregulated apoptosis in lung cancer cells to increase their radiosensitivity. +lncRNA target 31683435 hsa-mir-96 Pulmonary Fibrosis Conclusively, our research show that CBNPs-induced pulmonary fibrosis was at least partially depended on activation of NLRP3 inflammasome which modulated by miR-96 targeting FOXO3a. +lncRNA target 31683259 hsa-mir-133b Parkinson Disease All in all, silence of SNHG14 mitigates dopaminergic neuron injury by down-regulating alpha-syn via targeting miR-133b, which contributes to improving PD. +circulation_biomarker_diagnosis_up 31683019 hsa-mir-203a Osteoporosis, Postmenopausal Interestingly, teriparatide and zoledronate treatment were able to revert miRNA changes in tissue and serum of untreated OVX animals, such as the up-regulation of miR-203a-3p, a known osteo-inhibitory miRNA. +other 31682544 hsa-mir-122 Liver Diseases mfa-miR-122 and mfa-miR-192, potentially important biomarkers for liver toxicity, were also analyzed.3. Several cynomolgus microRNAs showed preferential tissue expressions: mfa-miR-1 in heart, mfa-miR-122 in liver and mfa-miR-21 and mfa-miR-192 in jejunum. +other 31681739 hsa-mir-582 Mesothelioma Notably, based on the co-expression patterns between ceRNAs and Immune cells, we found that the hsa-miR5p, CASP9, dendritic cells resting, ANIX2, T cells CD8, and T cells CD4 memory resting might be associated with the mesothelioma bone metastasis. +other 31681739 hsa-mir-582 Carcinoma, Hepatocellular Notably, based on the co-expression patterns between ceRNAs and Immune cells, we found that the hsa-miR5p, CASP9, dendritic cells resting, ANIX2, T cells CD8, and T cells CD4 memory resting might be associated with the mesothelioma bone metastasis. +lncRNA target 31681610 hsa-mir-375 Carcinoma, Hepatocellular 3p; and neutralized SS-inhibited growth of HCC cells. +other 31681604 hsa-mir-199a Brain Neoplasms Glioma is the most malignant brain tumors in the world, the function and molecular mechanism of microRNA-199a (miR-199a) in glioma is not fully understood. +lncRNA target 31681604 hsa-mir-199a high grade glioma Kinase suppressor of ras 1 (K-RAS), was indicated as a direct target of miR-199a, as well as expression levels of K-RAS were inversely correlated with expression levels of miR-199a in human glioma specimens. +other 31681594 hsa-mir-340 Leukemia, Myeloid, Acute AML cases showing low miR-340 levels should be strongly considered for early allo-HSCT treatment. +other 31681398 hsa-mir-5099 Ischemic Stroke, Cerebral Notably, this represents the first functional association of some of these miRNAs with stroke, e.g., miR-2137, miR5p, and miR-5099. +other 31681398 hsa-mir-2137 Ischemic Stroke, Cerebral Notably, this represents the first functional association of some of these miRNAs with stroke, e.g., miR-2137, miR5p, and miR-5099. +transcription factor target 31680974 hsa-mir-128 Breast Neoplasms Altogether, this study presents the first evidence that miR-128 suppresses the expression of HIC1 to accelerate breast cancerogenesis. +genetics_overexpression_suppress 31680766 hsa-mir-21 Retinoblastoma TCL6 overexpression inhibited Rb cell proliferation while miR-21 overexpression exerted an opposing effect; the effect of TCL6 overexpression was partially attenuated by miR-21 overexpression. +transcription factor target 31680642 hsa-mir-210 Atherosclerosis 3p and its target genes in macrophage lipid deposition and inflammatory response, and provide new ideas for the treatment of atherosclerosis. +lncRNA target 31680453 hsa-mir-21 Endomyocardial Fibrosis miR-21 inhibition decreased cardiac perivascular fibrosis by suppressing EndMT and up-regulating SMAD7 whereas activating p-SMAD2 and p-SMAD3. +lncRNA target 31680453 hsa-mir-21 Diabetes Mellitus, Type 1 miR-21 inhibition decreased cardiac perivascular fibrosis by suppressing EndMT and up-regulating SMAD7 whereas activating p-SMAD2 and p-SMAD3. +transcription factor target 31680452 hsa-mir-29b Squamous Cell Carcinoma of Head and Neck Here, we verified the miR-29b-3p as a guarder that suppressed migration and invasion of OSCC cells and was down-regulated in the most invasive cells. Thus, miR-29b-3p and IL32 might serve as therapeutic targets for blocking the progression and improving the outcome of OSCC. +genetics_knock down_suppress 31680324 hsa-mir-25 Osteoporosis 3p inhibitors in the treatment of periodontitis-related bone loss. +genetics_knock down_suppress 31680324 hsa-mir-25 Periodontitis 3p inhibitors in the treatment of periodontitis-related bone loss. +genetics_overexpression_suppress 31680323 hsa-mir-199a Osteosarcoma Importantly, miR-199a-5p's overexpression was associated with the OS cells' decreased proliferation and increased apoptosis. +lncRNA target 31680321 hsa-mir-7978 Adenocarcinoma of Lung In a word, this study innovatively investigated the mechanism of LINC00467 in LAD and verified LINC00467 exerted its carcinogenesis function by sponging miR-4779 and miR-7978, which may become a catalyst for generating new therapeutic targets for LAD treatment. +lncRNA target 31680321 hsa-mir-4779 Adenocarcinoma of Lung In a word, this study innovatively investigated the mechanism of LINC00467 in LAD and verified LINC00467 exerted its carcinogenesis function by sponging miR-4779 and miR-7978, which may become a catalyst for generating new therapeutic targets for LAD treatment. +circRNA target 31680319 hsa-mir-185 Carcinoma, Non-Small-Cell Lung Collectively, upregulated circ_0074027 in NSCLC accelerates cell progression via miR3p/BRD4/MADD pathway as a competing endogenous RNA. +lncRNA target 31680314 hsa-mir-23a Esophageal Squamous Cell Carcinoma Mechanically, we found a potential miRNA target, miR-23a, which negatively correlated with circ-Foxo3 in ESCC. Taken together, these results indicated that the circ-Foxo3/miR-23a/PTEN pathway was critical for inhibiting the ESCC progression. +other 31680313 hsa-mir-194 Glioma The modulation mechanism of the PCED1B-AS1/miR5p/PCED1B axis in glioma was investigated and affirmed, which supports researchers with a new insight into the therapy of patients with glioma. +lncRNA target 31680311 hsa-mir-135a Glioma Real-time quantitative polymerase chain reaction (RT-qPCR) was used to detect the expression of lncRNA UCA1, miR-135a, and HOXD9 in gliomas tissues. In conclusion, lncRNA UCA1 can induce the activation of HOXD9 by inhibiting the expression of miR-135a and promote the occurrence of EMT in glioma. +other 31680299 hsa-mir-1236 Carcinoma, Hepatocellular Analyses of HBV-related HCC specimens showed that the expression of AFP was negatively correlated with the levels of miR-1236 and miR-329. +other 31680299 hsa-mir-29 Carcinoma, Hepatocellular Analyses of HBV-related HCC specimens showed that the expression of AFP was negatively correlated with the levels of miR-1236 and miR-329. +other 31680298 hsa-mir-126 Glioma Taken together, we demonstrated a novel cellular mechanism that was dependent of the lncRNA-XIST/miR-126/IRS1/PI3K/Akt pathway in enhanced glucose metabolism in glioma. +circRNA target 31680239 hsa-mir-24 Diabetic Nephropathies 3p suppression, which subsequently promoted DN progression.In conclusion, we have reported a novel circ_0080425-miR +other 31680203 hsa-mir-146b Coronary Disease CONCLUSION: miR-146a and miR-146b predict increased restenosis and RASP risk in CHD patients who underwent PCI with DES. +other 31680118 hsa-mir-200 Clear-cell metastatic renal cell carcinoma The aim of this study is to analyse the of expression levels of microRNA-200 family members in patients with metastatic clear cell renal cell carcinoma (ccRCC). +other 31680118 hsa-mir-200c Clear-cell metastatic renal cell carcinoma MicroRna-200c was found to have significantly lower expression (in kidney tumour tissue compared to normal renal parenchyma. +genetics_knock down_promote 31680116 hsa-mir-129 Leukemia, Myeloid, Acute 5p improved neurological function by promoting functional recovery, reducing tissue loss and cell apoptosis in rats in an SCI model, possibly through downregulation of calpain1 and calpain2. +genetics_knock down_promote 31680116 hsa-mir-129 Spinal Cord Injuries 5p improved neurological function by promoting functional recovery, reducing tissue loss and cell apoptosis in rats in an SCI model, possibly through downregulation of calpain1 and calpain2. +genetics_knock down_promote 31679450 hsa-mir-25 Esophageal Squamous Cell Carcinoma Gain- and loss-of-function assays indicated that targeting miR-25 could reverse EMT, and reduce in vitro cell migration and invasion, but not apoptosis and proliferation of ESCC. +genetics_overexpression_promote 31679275 hsa-mir-384 Liver Neoplasms miR-384 was significantly decreased in HCC cells, and overexpression of miR-384 repressed HCC progression. +other 31679136 hsa-mir-139 Urinary Bladder Neoplasms RESULTS: In bladder cancer risk groups, mir-139, -136, -19 and 210 expressions or positivity were found to be different and concentrations of urinary Ape1/Ref1, BLCA4, CRK, and VIM increased by twofold on average compared to healthy controls. +lncRNA target 31679088 hsa-mir-525 Uterine Cervical Neoplasms 5p acts as a tumor suppressor in CC largely through repression of UBE2C/ZEB1/2 signaling. +transcription factor target 31678970 hsa-mir-3150b Colorectal Neoplasms Furthermore, miR-3150b-3p inhibited malignant biological behaviors by targeting GOLPH3, an oncogene in CRC. +circulation_biomarker_diagnosis_up 31678733 hsa-mir-204 Prostatic Neoplasms 5p as a serum biomarker in bone metastasis of PCa. +lncRNA target 31678422 hsa-mir-296 Thyroid Neoplasms CONCLUSION: Inhibition of LncRNA FOXD3-AS1 suppresses the aggressive biological behaviors of thyroid cancer via elevating miR +other 31678272 hsa-mir-197 Diabetic Retinopathy 5p in the pathogenesis of DR. +other 31678272 hsa-mir-2116 Diabetic Retinopathy 5p in the pathogenesis of DR. +lncRNA target 31678253 hsa-mir-200a Osteosarcoma Furthermore, we demonstrated that gankyrin protects miR-200a-mediated yes-associated protein (YAP) downregulation through p53 and establishes a positive feedback loop to regulate YAP signaling in U2OS and MG63 cells. +other 31678133 hsa-mir-214 Femur Head Necrosis CONCLUSION: MALAT1 was down-regulated, while miR-214 was elevated in SANFH tissues. +lncRNA target 31677796 hsa-mir-214 Carcinoma, Hepatocellular Silencing of PVT1 by ectopic miR-214 or siRNAs markedly inhibited viability and invasion of HCC cells. +lncRNA target 31677796 hsa-mir-214 Pulmonary Veno-Occlusive Disease Silencing of PVT1 by ectopic miR-214 or siRNAs markedly inhibited viability and invasion of HCC cells. +transcription factor target 31677784 hsa-mir-22 Cardiotoxicity In conclusion, miR-22 inhibition prevented oxidative stress and cardiomyocyte apoptosis via upregulating SIRT1 and miR-22 might be a new target for treating Dox-induced cardiotoxicity. +other 31677346 hsa-mir-486 Adenocarcinoma of Lung 5p were significantly increased in EVs from LUAD patients, compared to healthy controls. +other 31677346 hsa-mir-194 Adenocarcinoma of Lung 5p were significantly increased in EVs from LUAD patients, compared to healthy controls. +other 31677346 hsa-mir-451a Adenocarcinoma of Lung 5p were significantly increased in EVs from LUAD patients, compared to healthy controls. +other 31677258 hsa-mir-675 Nasopharyngeal Neoplasms 5p mimic cells was significantly lower than in mimic NC (negative control) group and blank control group. +other 31676795 hsa-mir-1976 Colorectal Neoplasms Our analyses showed miR-132, miR-378f, miR-605 and miR-1976 to be the most significantly downregulated miRNAs in primary and CRC liver metastatic tissues, and CRC cell lines. Consistently, CRC patients with higher miR-378f and miR-1976 levels exhibited better survival. +lncRNA target 31676570 hsa-mir-146a Coxsackievirus Infections The elevated miR-146a inhibited NF-kappaB translocation and subsequently down-regulated proinflammatory cytokine expression in the CVB3-infected cells. +lncRNA target 31676070 hsa-mir-185 Osteosarcoma This study uncovers a novel underlying molecular mechanism of PCAT6-miR5p-TGFBR1/2-TGF-beta signaling axis in promoting tumor progression in OS, which indicates that PCAT6 may serve as a promising prognostic factor and therapeutic target again OS. +lncRNA target 31675930 hsa-mir-154 Breast Neoplasms CONCLUSIONS: It was concluded that the inhibition of NAD production by miR-154 might be introduced as an appropriate therapeutic approach in order to improve breast cancer outcome either alone or in combination with other conventional chemotherapeutic agents. +lncRNA target 31675755 hsa-mir-133b Colorectal Neoplasms FTL expression upregulated in CRC via Linc00467/ miR-133b axis, and leads to CRC cell resistance against 5-FU treatment and promotes CRC metastasis. FTL expression upregulated in CRC via Linc00467/miR-133b axis, and leads to CRC cell resistance to 5-FU treatment and promotes CRC metastasis. +genetics_overexpression_suppress 31675585 hsa-mir-731 Cerebral Hemorrhage OTA-induced intracerebral hemorrhage and CtA vessel defects were partially reversed by the presence of miR-731 antagomir or the overexpression of prolactin receptor a (prlra); prlra is a downstream target of miR-731. +transcription factor target 31675481 hsa-mir-206 Muscular Diseases Taken together, we demonstrated that the miRG6PD pathway suppresses muscle cell proliferation, and these findings may facilitate the treatment of muscle diseases.-Jiang, A., Dong, C., Li, B., Zhang, Z., Chen, Y., Ning, C., Wu, W., Liu, H. +other 31675172 hsa-mir-590 Cardiomyopathies However, the molecular mechanisms for how miR3p involves in cardiac fibrosis remain largely unexplored. +lncRNA target 31675172 hsa-mir-590 Myocardial Infarction 3p as the therapeutic target to recover cardiac function following MI. +circulation_biomarker_diagnosis_ns 31675148 hsa-mir-4 Myocardial Infarction, Acute 3p (AUC: 0.772); miR-4,507 (AUC: 0.684); and miR-3,656 (AUC: 0.771)], suggesting that these serum exosomal miRNAs might be predictive for AMI at an early stage. +circulation_biomarker_diagnosis_ns 31675148 hsa-mir-1915 Myocardial Infarction, Acute 3p (AUC: 0.772); miR-4,507 (AUC: 0.684); and miR-3,656 (AUC: 0.771)], suggesting that these serum exosomal miRNAs might be predictive for AMI at an early stage. +transcription factor target 31675124 hsa-mir-155 Arthritis, Rheumatoid Immunopharmacological effect of -d-mannuronic acid (M2000), as a new immunosuppressive drug, on gene expression of miR-155 and its target molecules (SOCS1, SHIP1) in a clinical trial on rheumatoid arthritis patients. +genetics_overexpression_promote 31674056 hsa-mir-598 Retinoblastoma Overexpression of miR-598 suppressed the viability and metastasis of RB cells. +lncRNA target 31674022 hsa-mir-196b Stomach Neoplasms Taken together, LINC00629 competitively bound to miR-196b-5p to upregulate AQP4 expression, thereby inhibiting gastric cancer progression. +lncRNA target 31674013 hsa-mir-142 Breast Neoplasms 3p could function as a tumor suppressor via targeting RAC1/PAK1 pathway in BC, suggesting a potent therapeutic target for BC treatment. +lncRNA target 31673844 hsa-mir-219a-2 Stomach Neoplasms CONCLUSION: LBX2-AS1/miR-219a3p/FUS/LBX2 positive feedback loop mainly affected the proliferation and apoptosis abilities of GC cells, offering novel therapeutic targets for the treatment of patients with GC. +genetics_GWAS 31673240 hsa-mir-425 Colorectal Neoplasms 5p might act as an oncogene to participate in the pathogenesis of KRAS-mutated CRC and contribute to increase the aggressiveness of this subcategory of CRC, controlling a complex molecular network. +other 31673075 hsa-mir-203b Skin Neoplasms This study reveals the genes C7, MMP3, KRT14, LOC642587, CASP7, S100A7 and miRNAs hsa-mir-205 and hsa-mir-203b as the key genomic features that may substantially contribute to the oncogenesis of melanoma. +other 31673075 hsa-mir-205 Skin Neoplasms This study reveals the genes C7, MMP3, KRT14, LOC642587, CASP7, S100A7 and miRNAs hsa-mir-205 and hsa-mir-203b as the key genomic features that may substantially contribute to the oncogenesis of melanoma. +other 31672997 hsa-mir-150 Sepsis The critical importance of housekeeping gene selection is emphasized by exemplary quantification of imuno-miR-150 in sepsis patients. +other 31672851 hsa-mir-1 Chronic recurrent multifocal osteomyelitis In addition, miR-1 and miR-133b levels at 90 min post-PPCI were approximately 3-fold (P = 0.001) and 4.4-fold (P = 0.008) higher in patients with MVO, respectively. +other 31672851 hsa-mir-133b Chronic recurrent multifocal osteomyelitis In addition, miR-1 and miR-133b levels at 90 min post-PPCI were approximately 3-fold (P = 0.001) and 4.4-fold (P = 0.008) higher in patients with MVO, respectively. +other 31672647 hsa-mir-28 Carcinoma, Renal Cell Additionally, miR3p displayed significantly down-regulated expression in progressive relative to non-progressive ccRCC-SRMs. +other 31672639 hsa-mir-25 Wounds and Injuries The use of BB after severe trauma can help mitigate persistent inflammation by upregulating Rno-miR-27a and miR-25 and reducing inflammatory cytokines in those who remain critically ill. +other 31672639 hsa-mir-25 Stroke The use of BB after severe trauma can help mitigate persistent inflammation by upregulating Rno-miR-27a and miR-25 and reducing inflammatory cytokines in those who remain critically ill. +lncRNA target 31672604 hsa-mir-34a Prostatic Neoplasms Innovatively, we concluded that NEAT1 contributes to the docetaxel resistance by increasing ACSL4 via sponging miR-34a-5p and miR +lncRNA target 31672604 hsa-mir-204 Prostatic Neoplasms Innovatively, we concluded that NEAT1 contributes to the docetaxel resistance by increasing ACSL4 via sponging miR-34a-5p and miR +genetics_knock down_promote 31672492 hsa-mir-4516 Triple Negative Breast Neoplasms Among miR-4516 targets, FOSL1 was overexpressed in TNBC cells compared to non-TNBC cells and promoted tumor proliferation. +circulation_biomarker_diagnosis_ns 31672436 hsa-mir-21 Infertility We measured 10 monohydroxylated PAHs (OH-PAHs) in repeated urine samples and three candidate spermatogenesis-related miRNAs (miRNA106a, miRNA21, and miRNA34c) in seminal plasma from men attending an infertility clinic (n=111). +circulation_biomarker_diagnosis_ns 31672436 hsa-mir-106a Infertility We measured 10 monohydroxylated PAHs (OH-PAHs) in repeated urine samples and three candidate spermatogenesis-related miRNAs (miRNA106a, miRNA21, and miRNA34c) in seminal plasma from men attending an infertility clinic (n=111). +transcription factor target 31672275 hsa-mir-124 Heart Injuries Our results suggested that miR-124 was hopeful to become a therapeutic target in doxorubicin-related cardiomyopathy. +transcription factor target 31672272 hsa-mir-574 Cardiomyopathies 5p and arid3a may be a novel therapeutic target for cardiac fibrosis. +circulation_biomarker_diagnosis_ns 31672150 hsa-mir-3113 Myocardial Reperfusion Injury Our data suggested that cardiac microRNA 3113-5p might be a useful target for therapeutic purposes and circulating microRNA 3113-5p might serve as a stable marker for early diagnosis of cardiac I/R injury. +genetics_overexpression_promote 31672084 hsa-mir-146a Triple Negative Breast Neoplasms Therefore, overexpression of miR-146a-5p may promote triple-negative breast cancer cell invasion and migration by upregulating HOTAIR. +virus_miRNA 31671936 ebv-mir-BHRF1-1 Leukemia, Lymphocytic, Chronic, B-Cell EBV-miR-BHRF1- 1 inhibition upregulated p53 protein expression, induced cell cycle arrest and apoptosis and decreased cell proliferation in cell lines. +genetics_overexpression_promote 31671847 hsa-mir-25 Colorectal Neoplasms 5p at mRNA level and conversely NEDD9 overexpression or miR +other 31671785 hsa-mir-101 Fatty Liver miR3p was reduced in InsR+/- hepatocytes and HSCs and even more in InsR+/- cells exposed to insulin (0.33 microM) and fatty acids (0.25 mM), resembling the IR-NASH model. +lncRNA target 31671785 hsa-mir-101 Insulin Resistance 3p downregulation, which may promote progressive NAFLD through HSC and hepatocyte transdifferentiation and proliferation. +other 31671785 hsa-mir-101 Macular dystrophy, corneal type 1 We found that miR3p negatively associated with both InsR+/- genotype and MCD (p < 0.05) and the histological spectrum of liver damage (p < 0.01). +transcription factor target 31671785 hsa-mir-101 Chemical and Drug Induced Liver Injury 3p downregulation, which may promote progressive NAFLD through HSC and hepatocyte transdifferentiation and proliferation. +circulation_biomarker_diagnosis_ns 31671598 hsa-mir-29 Cognitive Dysfunction Cognitive parameters, Abeta and amyloid precursor protein (APP) expression, microRNA 29, and long non-coding RNA in isolated platelets as well as NETs in peripheral blood were investigated. +circulation_biomarker_diagnosis_ns 31671598 hsa-mir-29 Alzheimer Disease Cognitive parameters, Abeta and amyloid precursor protein (APP) expression, microRNA 29, and long non-coding RNA in isolated platelets as well as NETs in peripheral blood were investigated. +other 31671574 hsa-mir-335 Alzheimer Disease Mir5p was specific for ADD, suggesting that it may be useful as a biomarker. +other 31671574 hsa-mir-335 Cognitive Dysfunction Mir5p was specific for ADD, suggesting that it may be useful as a biomarker. +other 31671404 hsa-mir-29c Uterine Diseases To conclude, miR-29c-3p in endometrial cells regulates uterine contractility by attenuating the expression of OXTR and reducing PGF2alpha release. +other 31671225 hsa-mir-34a Infertility In this study, dynamics of sperm miR-15a, miR-29b and miR-34a from high fertility (HF) and low fertility (LF) bulls using RT-qPCR were evaluated. +other 31671225 hsa-mir-29b Infertility In this study, dynamics of sperm miR-15a, miR-29b and miR-34a from high fertility (HF) and low fertility (LF) bulls using RT-qPCR were evaluated. +other 31671225 hsa-mir-15a Infertility We found an inverse correlation between miR-15a and bull fertility. +other 31670914 hsa-mir-181a Leukemia, Myeloid, Acute It further supported that miR-181a could be a useful marker for AML prognosis and possibly worked by regulating HOXA gene clusters. +lncRNA target 31670868 hsa-mir-199a Carcinoma, Hepatocellular Notably, the miR-199a-5p/ARL2 axis is necessary for ANRIL-mediated promoting effects on HCC cell mitochondrial function. This work reveals a novel ANRIL-miR-199a-5p-ARL2 axis in HCC cell progression, which might provide potential targets for HCC treatment. +genetics_overexpression_promote 31670857 hsa-mir-98 Thyroid Cancer, Papillary Overexpression of miRNA +transcription factor target 31669961 hsa-mir-21 Tissue Adhesions HE staining was used to determine the role of miR-21 in scar tissue formation in a model of joint adhesion. Our study shows that MMC can induce fibroblast apoptosis and prevent joint adhesion by regulating the expression of miR-21 and its target PDCD4. +genetics_overexpression_promote 31669646 hsa-mir-155 Osteosarcoma MicroRNA-155 (miR-155) has been identified to be overexpressed in various human cancers including osteosarcoma. +other 31669642 hsa-mir-512 Prostatic Neoplasms 3p, so as to realize the regulation effect on the proliferation, invasion and migration of prostate cancer cells, and thereby promote the occurrence and development of prostate cancer, so as to provide the corresponding program for the treatment of prostate cancer. +other 31669638 hsa-mir-25 Spinal Cord Injuries 3p), and three lncRNAs (Neat1, Xist, and Malat1) are likely to be involved in the molecular mechanisms underlying the subacute stage of SCI. +exosome 31669517 hsa-mir-92a Colorectal Neoplasms In order to investigate CRC-derived exosomes, we selected mi-R19a, miR-21, miR-92a, and miR-1246 positive exosomes for downstream experiments. +exosome 31669517 hsa-mir-1246 Colorectal Neoplasms In order to investigate CRC-derived exosomes, we selected mi-R19a, miR-21, miR-92a, and miR-1246 positive exosomes for downstream experiments. +exosome 31669517 hsa-mir-21 Colorectal Neoplasms In order to investigate CRC-derived exosomes, we selected mi-R19a, miR-21, miR-92a, and miR-1246 positive exosomes for downstream experiments. +other 31669252 hsa-mir-335 Osteoporotic Fractures 5p) in patients with vertebral fractures and low BMD compared to low BMD and healthy individuals, regardless of osteoporosis treatment. +other 31669252 hsa-mir-532 Osteoporotic Fractures 5p) in patients with vertebral fractures and low BMD compared to low BMD and healthy individuals, regardless of osteoporosis treatment. +other 31669252 hsa-mir-23a Osteoporotic Fractures 5p) in patients with vertebral fractures and low BMD compared to low BMD and healthy individuals, regardless of osteoporosis treatment. +other 31669240 hsa-mir-145 Pre-Eclampsia OBJECTIVE: We aimed to explore the expression level and biological function of miR5p in preeclampsia (PE). +other 31669240 hsa-mir-145 Pneumonia, Mycoplasma 5p may participate in PE development by affecting the proliferation and invasion of trophoblast cells. +other 31669140 hsa-mir-520h Colorectal Neoplasms Mechanistically, PART1 sponged miR5p/miR-520 h to up-regulate CTNNB1, thus activating Wnt/beta-catenin pathway in CRC. +other 31669140 hsa-mir-150 Colorectal Neoplasms Mechanistically, PART1 sponged miR5p/miR-520 h to up-regulate CTNNB1, thus activating Wnt/beta-catenin pathway in CRC. +genetics_overexpression_promote 31668943 hsa-mir-139 Carcinoma, Hepatocellular Quantitative real-time polymerase chain reaction (qRT-PCR), Western blot and cell apoptosis assay revealed that pre-miR-139, -203a, -378a and -422a plasmids among the six miRNA overexpression vectors could suppress growth of the hepatoma cell line SMMC-7721. +other 31668923 hsa-mir-622 Adenocarcinoma of Lung Furthermore, hsa-circ-0000211 promoted the migration and invasion of LAC by sponging miR-622. hsa-circ-0000211 promoted LAC cell migration and invasion by modulating the miR-622/HIF1-alpha network. +genetics_overexpression_suppress 31668807 hsa-mir-218 Pulmonary Disease, Chronic Obstructive MiR-218 was downregulated in COPD tissues and (CSE)-treated or MEG3 overexpressed 16HBE cells. +circulation_biomarker_diagnosis_up 31668631 hsa-mir-146b Renal Insufficiency, Chronic Additionally, miR-146b(-/-) female rats exhibited a marked elevation of renal fibrosis and significant renal dysfunction yet lower blood pressure and less pronounced cardiac remodeling. +lncRNA target 31668391 hsa-mir-873 Non-alcoholic Fatty Liver Disease 5p and its targeting arises as a valuable therapeutic option for treatment. +genetics_GWAS 31668372 hsa-mir-421 Stomach Neoplasms Next, Pull-down assay and dual-luciferase reporter assay verified that miR-421 was a target of circ_0001546 while ATM (Ataxia telangiectasia mutated) was target by miR-421. +other 31668144 hsa-mir-155 Diabetic Nephropathies 5p/PTEN signaling and PI3K/AKT/mTOR signaling pathway in DN. +other 31668144 hsa-mir-155 Fibrosis, Renal 5p/PTEN signaling and PI3K/AKT/mTOR signaling pathway in DN. +lncRNA target 31668113 hsa-mir-491 hereditary diffuse gastric cancer CONCLUSION: Our results suggest that miR-491 suppressed cell proliferation and cell motility in gastric cancer by targeting HMGA2. +genetics_overexpression_promote 31667976 hsa-mir-200b Glioma Importantly, both CHD1 overexpression and miR-200b/c/429 inhibition could rescue the obstructive role of MATN1-AS1 silence in glioma cells. +genetics_overexpression_promote 31667976 hsa-mir-200c Glioma Importantly, both CHD1 overexpression and miR-200b/c/429 inhibition could rescue the obstructive role of MATN1-AS1 silence in glioma cells. +genetics_overexpression_promote 31667976 hsa-mir-429 Glioma Importantly, both CHD1 overexpression and miR-200b/c/429 inhibition could rescue the obstructive role of MATN1-AS1 silence in glioma cells. +lncRNA target 31667786 hsa-mir-19b Osteosarcoma When cotransfected with circ_ANKIB1 siRNA and miR-19b mimics or SOCS3 siRNA, the cell proliferation, apoptosis, and invasion levels did not change significantly, suggesting that circ_ANKIB1 could affect the STAT3 pathway and osteosarcoma cell growth and invasion by enhancing the regulation of miR-19b on the downstream target gene SOCS3. +lncRNA target 31667785 hsa-mir-1179 Adenocarcinoma of Lung Hence, our results authenticated that lncRNA LINC00857 regulated the cell proliferation, glycolysis and apoptosis of LUAD cells mainly through targeting the miR-1179/SPAG5 axis, which might be a novel insight into lung cancer progression and provided a potential target for clinical treatment of LUAD patients. +genetics_knock down_promote 31667686 hsa-mir-130b Prostatic Neoplasms In vitro gain-of-function assays and loss-of-function assays were conducted to explore the potential functions of miR-130b in human prostate cancer cells. +genetics_knock down_promote 31667207 hsa-mir-181a Squamous Cell Carcinoma of Head and Neck Either knockdown of ANRIL or overexpression of miR-181a significantly inhibited the proliferation, clonogenicity, invasion, migration and epithelial mesenchymal transformation (EMT), as well as promoted the apoptosis of LSCC cells, and knockdown of miR-181a reversed the effects. +transcription factor target 31666682 hsa-mir-5587 Adenocarcinoma of Lung Of note, we also identified miR3p as a negative upstream regulator of WNT5B in LAD, which may help develop therapies targeting LAD patients with high WNT5B expression. +circulation_biomarker_diagnosis_ns 31666440 hsa-mir-17 Instent Restenosis This study identified miR-17 and its related biomarkers in serum that potentially indicated susceptibility to in-stent restenosis (ISR) after coronary artery stenting. +exosome 31666098 hsa-mir-145 Ovarian Neoplasms CONCLUSIONS: Our study demonstrates the highly expressed circWHSC1 in ovarian cancer promotes tumorigenesis by sponging miR-145 and miR-1182, and its exosome forms induce tumor metastasis through acting on peritoneal mesothelium. +exosome 31666098 hsa-mir-1182 Ovarian Neoplasms CONCLUSIONS: Our study demonstrates the highly expressed circWHSC1 in ovarian cancer promotes tumorigenesis by sponging miR-145 and miR-1182, and its exosome forms induce tumor metastasis through acting on peritoneal mesothelium. +genetics_overexpression_suppress 31665807 hsa-mir-147b Carcinoma, Non-Small-Cell Lung Overexpression of RPS15A partially reversed the miR-147b-mediated antitumour effect in NSCLC cells. +exosome 31665717 hsa-mir-181c Parkinson Disease This study aimed to investigate whether cortical neuron-released exosomal microRNA-181c-3p (miR-181c-3p) affected ischemic brain injury (IBI). CONCLUSION: Collectively, exosomal miR-181c-3p derived from cortical neurons exerts protective effects on neuroinflammation in astrocytes via downregulation of CXCL1 in an IBI rat model. +exosome 31665717 hsa-mir-181c Hypoxia-Ischemia, Brain This study aimed to investigate whether cortical neuron-released exosomal microRNA-181c-3p (miR-181c-3p) affected ischemic brain injury (IBI). CONCLUSION: Collectively, exosomal miR-181c-3p derived from cortical neurons exerts protective effects on neuroinflammation in astrocytes via downregulation of CXCL1 in an IBI rat model. +lncRNA target 31665654 hsa-mir-223 Breast Neoplasms Finally, we demonstrated that physiological delivery of platelet miR-223 and miR-126 induced cellular effects in breast cancer cells, including cell cycle arrest, inhibition of migration and sensitivity to cisplatin. +lncRNA target 31665654 hsa-mir-126 Breast Neoplasms Finally, we demonstrated that physiological delivery of platelet miR-223 and miR-126 induced cellular effects in breast cancer cells, including cell cycle arrest, inhibition of migration and sensitivity to cisplatin. +genetics_GWAS 31665376 hsa-mir-146a Multiple Sclerosis In contrast to our previous findings on MS macrophages, expression of 2 classical inflammatory-related miRNAs, miRNA-155 and miRNA-146a, was reduced in astrocytes from active and chronic active MS lesions in white and grey matter, suggesting a lesser direct pathogenetic role for these miRNAs in astrocytes. +genetics_GWAS 31665376 hsa-mir-155 Multiple Sclerosis In contrast to our previous findings on MS macrophages, expression of 2 classical inflammatory-related miRNAs, miRNA-155 and miRNA-146a, was reduced in astrocytes from active and chronic active MS lesions in white and grey matter, suggesting a lesser direct pathogenetic role for these miRNAs in astrocytes. +other 31665127 hsa-mir-34b Inflammation Although microRNAs (miRNAs) are known to have roles in inflammation-related disorders, the exact role of miR-34b in DN has not been defined, and the regulatory mechanism has been unclear. +genetics_overexpression_promote 31665008 hsa-mir-124 Squamous Cell Carcinoma of Head and Neck CASC15 overexpression resulted in the increased, while miR-124 overexpression resulted in the decreased migration and invasion rates of TSCC cells. +genetics_overexpression_promote 31664866 hsa-mir-195 Pancreatic Carcinoma Results: Both the knock down of lncRNA SNHG16 and SREBP2 and overexpression of miR-195 suppressed the proliferation, migration, invasion and lipogenesis in pancreatic cancer cells. Conclusion: LncRNA SNHG16 accelerated the development of pancreatic cancer and promoted lipogenesis via directly regulating miR-195/SREBP2 axis. +lncRNA target 31664601 hsa-mir-665 Heart Failure Our data showed that nuclear miR-665 aggravates heart failure via inhibiting PTEN expression, which provided a therapeutic approach for heart failure. +other 31664600 hsa-mir-98 Ovarian Neoplasms, High-Grade Serous 3p that could serve as indicators of resistance to platinum-based chemotherapy, thereby contributing to the improvement of chemotherapeutic efficiency and optimization of personalized treatments in HGSC. +other 31664600 hsa-mir-22 Ovarian Neoplasms, High-Grade Serous 3p that could serve as indicators of resistance to platinum-based chemotherapy, thereby contributing to the improvement of chemotherapeutic efficiency and optimization of personalized treatments in HGSC. +other 31664305 hsa-mir-129 Breast Neoplasms 5p/HMGB1/autophagy-based therapeutic strategies may be a potential treatment for overcoming Taxol resistance in breast cancer. +other 31663987 hsa-mir-125b Osteoporosis, Postmenopausal 5p, and hsa-miR-30d-5p in a cohort of 149 postmenopausal women divided into subgroups based on the amount of physical activity by using quantitative polymerase chain reaction (qPCR). +other 31663987 hsa-mir-21 Osteoporosis, Postmenopausal 5p, and hsa-miR-30d-5p in a cohort of 149 postmenopausal women divided into subgroups based on the amount of physical activity by using quantitative polymerase chain reaction (qPCR). +other 31663987 hsa-mir-93 Osteoporosis, Postmenopausal 5p, and hsa-miR-30d-5p in a cohort of 149 postmenopausal women divided into subgroups based on the amount of physical activity by using quantitative polymerase chain reaction (qPCR). +other 31663987 hsa-mir-148a Osteoporosis, Postmenopausal 5p, and hsa-miR-30d-5p in a cohort of 149 postmenopausal women divided into subgroups based on the amount of physical activity by using quantitative polymerase chain reaction (qPCR). +other 31663629 hsa-mir-138 Cholangiocarcinoma Here, we demonstrate that decreased miR-138 in tumor tissues is related to the poor prognosis in patients, and that miR-138 mediates sorafenib-induced cell survival in cholangiocarcinoma cells. Overall, the present study reveals that miR-138/SOX4 is involved in sorafinib-mediated cell survival in cholangiocarcinoma cells, and is associated with poor prognosis. +genetics_overexpression_promote 31663517 hsa-mir-29 Uterine Cervical Neoplasms RESULTS LncRNA TP73-AS1 was overexpressed in cervical cancer tissues and cells and was associated with reduced expression of miR +lncRNA target 31663299 hsa-mir-218 Stomach Neoplasms In conclusion, dysregulation of miR +lncRNA target 31663299 hsa-mir-195 Stomach Neoplasms In conclusion, dysregulation of miR +other 31663225 hsa-mir-4508 Silicotuberculosis CONCLUSION miRNA-4508 may be a potential diagnostic marker for SPF, and rs6576457, a functional variant of miRNA-4508, may affect SPF susceptibility. +circulation_biomarker_diagnosis_ns 31663165 hsa-mir-19b Brain Neoplasms Furthermore, the feasibility of the biosensor platform to detect miR-19b in serum samples of children, suffering from brain cancer, is demonstrated. +genetics_overexpression_promote 31663131 hsa-mir-34a Squamous Cell Carcinoma of Head and Neck In cases where the miR-34a levels were low, the SATB2 in OSCCs seemed to be overexpressed. +genetics_overexpression_suppress 31662757 hsa-mir-181a Lymphoma, B-Cell, Diffuse Overexpression of miR-181a in ABC-like DLBCL cell lines (OCI-LY10 and U2932) resulted in G0/G1 cell cycle arrest, increased apoptosis, and decreased invasiveness. These results indicate that miR-181a inhibits ABC-like DLBCL by repressing CARD11. +genetics_knock down_promote 31662451 hsa-mir-29a Pancreatic Carcinoma miR-29a is commonly downregulated in PDAC; however, mechanisms for its loss and role still remain unclear. +other 31661835 hsa-mir-482a Disease Among these, nine PHAS genes were triggered by miR167, miR390, miR482a, and two novel miRNAs, including those encoding a leucine-rich repeat (LRR) disease resistance protein, an auxin response factor (ARF) and MYB transcription factors. +other 31661835 hsa-mir-390 Disease Among these, nine PHAS genes were triggered by miR167, miR390, miR482a, and two novel miRNAs, including those encoding a leucine-rich repeat (LRR) disease resistance protein, an auxin response factor (ARF) and MYB transcription factors. +other 31661791 hsa-mir-365b Carcinoma, Renal Cell 3p, TFAP2A, KLF5, IRF1, MYC, IKZF1) that could combine as a signature to improve the prognosis effect of ccRCC patients, which distinctly outperformed the eight-miRNA signature and the nine-TF signature. +other 31661791 hsa-mir-335 Carcinoma, Renal Cell 3p, TFAP2A, KLF5, IRF1, MYC, IKZF1) that could combine as a signature to improve the prognosis effect of ccRCC patients, which distinctly outperformed the eight-miRNA signature and the nine-TF signature. +other 31661791 hsa-mir-223 Carcinoma, Renal Cell 3p, TFAP2A, KLF5, IRF1, MYC, IKZF1) that could combine as a signature to improve the prognosis effect of ccRCC patients, which distinctly outperformed the eight-miRNA signature and the nine-TF signature. +other 31661791 hsa-mir-144 Carcinoma, Renal Cell 3p, TFAP2A, KLF5, IRF1, MYC, IKZF1) that could combine as a signature to improve the prognosis effect of ccRCC patients, which distinctly outperformed the eight-miRNA signature and the nine-TF signature. +other 31661791 hsa-mir-1269a Carcinoma, Renal Cell 3p, TFAP2A, KLF5, IRF1, MYC, IKZF1) that could combine as a signature to improve the prognosis effect of ccRCC patients, which distinctly outperformed the eight-miRNA signature and the nine-TF signature. +other 31661791 hsa-mir-183 Carcinoma, Renal Cell 3p, TFAP2A, KLF5, IRF1, MYC, IKZF1) that could combine as a signature to improve the prognosis effect of ccRCC patients, which distinctly outperformed the eight-miRNA signature and the nine-TF signature. +genetics_knock down_suppress 31661551 hsa-mir-34a Uveal melanoma Transfection with miR-34a or knockdown of LGR4 attenuated the aggressiveness of uveal melanoma cells. +lncRNA target 31661546 hsa-mir-129 Arthritis, Rheumatoid 5p regulated cell proliferation and apoptosis via IGF-1R/Src/ERK/Egr-1 signaling pathway in RA. +genetics_overexpression_promote 31661371 hsa-mir-519d Glioma Furthermore, restoration of CCND1 reversed the effects of miR-519d-3p overexpression in glioma cells. +genetics_knock down_promote 31661146 hsa-mir-143 Breast Neoplasms Knockdown of PSMG3AS1 increased the level of miR1433p expression, which led to the mitigation of proliferation and migration capacity in breast carcinoma cells. +lncRNA target 31661144 hsa-mir-760 Arthritis, Rheumatoid The results of the present study may contribute to understanding the mechanisms underlying RA skeletal muscle proliferation, and miR760/Myo18b may serve as potential targets for treating patients with RA. +other 31661131 hsa-mir-486 Carcinoma, Renal Cell In conclusion, our findings indicate that miR486 may serve as a novel prognostic biomarker but may also be applied as a new therapeutic approach for the treatment of RCC. +circulation_biomarker_diagnosis_ns 31661117 hsa-mir-508 Carcinoma, Renal Cell We discovered that serum miR5083p and miR8855p were significantly dysregulated in ccRCC patients with marked diagnostic values. In conclusion, serum miR5083p and miR8855p are novel potential biomarkers for the diagnosis of ccRCC. +circulation_biomarker_diagnosis_ns 31661117 hsa-mir-885 Carcinoma, Renal Cell We discovered that serum miR5083p and miR8855p were significantly dysregulated in ccRCC patients with marked diagnostic values. In conclusion, serum miR5083p and miR8855p are novel potential biomarkers for the diagnosis of ccRCC. +epigenetics 31660998 hsa-mir-133a Breast Neoplasms RESULTS: We confirmed that miR-133a-3p was silenced by DNA hypermethylation in breast cancer cell lines and tissues, which predicted poor prognosis in breast cancer patients, and reducing miR-133a-3p expression led to a significant increase in the migration, invasion, proliferation, and stemness of breast cancer cells in vitro. +lncRNA target 31660971 hsa-mir-34c Acute Lung Injury CONCLUSION: This study demonstrated that lncRNA SNHG14 silencing alleviated inflammation in LPS-induced ALI through miR-34c-3p-mediated inhibition of WISP1. +other 31660895 hsa-mir-375 Thyroid Neoplasms RESULTS A minimum set of markers was selected (levels of HMGA2 mRNA and miR-375, -221, and -146b in combination with the mitochondrial-to-nuclear DNA ratio) and yielded highly accurate discrimination (sensitivity=0.97; positive predictive value=0.98) between goiters with benign tumors and malignant tumors and accurate typing of papillary, medullary, and Hrthle cell carcinomas. +other 31660891 hsa-mir-141 Carcinoma, Hepatocellular We found that miR-141 and miR-146 correlated with cirrhosis in tumor tissue and normal tissue, respectively. +circulation_biomarker_diagnosis_ns 31660891 hsa-mir-122 Carcinoma, Hepatocellular Comparing serum from HCC patients with serum from healthy individuals revealed a global increase of miRNAs in serum from HCC patients, including an almost 4-fold increase of several miRNAs, including the liver-specific miR-122. +other 31660891 hsa-mir-146 Carcinoma, Hepatocellular We found that miR-141 and miR-146 correlated with cirrhosis in tumor tissue and normal tissue, respectively. +other 31660855 hsa-mir-21 psoriasis 1 CONCLUSION: MEG3/miR-21 axis may regulate the expression of caspase-8, and further influence the proliferation and apoptosis of psoriasis keratinocyte, Act-HaCaT and Act- HHEK. +other 31660818 hsa-mir-7 Stroke Curcumin improved cerebral infarction, nerve damage and cognitive dysfunction in rats with CIR, which may be related to the regulation of miR5p/RelA p65 axis. +circulation_biomarker_diagnosis_up 31660696 hsa-mir-21 Carcinoma, Hepatocellular CONCLUSION: The circulating miR-130b and miR-21 can be used as potential tumor biomarkers to diagnose liver cancer, and the combined detection of serum miR-130b and miR-21 is superior to the diagnosis of HCC. +circulation_biomarker_diagnosis_up 31660696 hsa-mir-130b Carcinoma, Hepatocellular CONCLUSION: The circulating miR-130b and miR-21 can be used as potential tumor biomarkers to diagnose liver cancer, and the combined detection of serum miR-130b and miR-21 is superior to the diagnosis of HCC. +other 31660262 hsa-mir-25 Melanoma A five-miRNA (miR-25, miR-204, miR-211, miR-510, miR-513c) signature was discovered to be a potential significant prognostic biomarker of cutaneous melanoma when using the Kaplan-Meier survival method (P = 0.001). +other 31660262 hsa-mir-510 Melanoma A five-miRNA (miR-25, miR-204, miR-211, miR-510, miR-513c) signature was discovered to be a potential significant prognostic biomarker of cutaneous melanoma when using the Kaplan-Meier survival method (P = 0.001). +other 31660262 hsa-mir-204 Melanoma A five-miRNA (miR-25, miR-204, miR-211, miR-510, miR-513c) signature was discovered to be a potential significant prognostic biomarker of cutaneous melanoma when using the Kaplan-Meier survival method (P = 0.001). +other 31660262 hsa-mir-211 Melanoma A five-miRNA (miR-25, miR-204, miR-211, miR-510, miR-513c) signature was discovered to be a potential significant prognostic biomarker of cutaneous melanoma when using the Kaplan-Meier survival method (P = 0.001). +other 31660262 hsa-mir-513c Melanoma A five-miRNA (miR-25, miR-204, miR-211, miR-510, miR-513c) signature was discovered to be a potential significant prognostic biomarker of cutaneous melanoma when using the Kaplan-Meier survival method (P = 0.001). +exosome 31660076 hsa-mir-21 Atherosclerosis Conclusion: Exosomal miR3p from nicotine-treated macrophages may accelerate the development of atherosclerosis by increasing VSMC migration and proliferation through its target PTEN. +lncRNA target 31660034 hsa-mir-4455 Stomach Neoplasms CONCLUSION: LINC02407 plays a role in GC through the LINC02407-miR +lncRNA target 31660034 hsa-mir-6845 Stomach Neoplasms CONCLUSION: LINC02407 plays a role in GC through the LINC02407-miR +circulation_biomarker_diagnosis_up 31659408 hsa-mir-409 Diabetes Mellitus 3p may represent a new circulating biomarker of islet inflammation and type 1 diabetes severity. +circulation_biomarker_diagnosis_up 31659408 hsa-mir-409 Diabetes Mellitus, Type 1 3p may represent a new circulating biomarker of islet inflammation and type 1 diabetes severity. +other 31659197 hsa-mir-200b Alzheimer Disease Among individual microRNAs, microRNA-200b-5p was identified as a potential biomarker for AD with elevated levels present in AD tear fluid samples compared to controls. +lncRNA target 31659158 hsa-mir-18a Nasopharyngeal Carcinoma Our data support an oncogenic role of miR-18a through a novel miR-18a/SMG1/mTOR axis and suggest that the antitumor effects of antagomir-18a may make it suitable for NPC therapy. +genetics_knock down_promote 31659154 hsa-mir-421 Carcinoma, Non-Small-Cell Lung Interestingly, overexpression of miR-421 reduced the level of KEAP1 expression, which further promoted lung cancer cell migration and invasion, as well as inhibited cell apoptosis both in vivo and in vitro. +lncRNA target 31659146 hsa-mir-144 Carcinoma, Non-Small-Cell Lung 3p expression was inhibited. +lncRNA target 31659098 hsa-mir-362 Breast Neoplasms 3p targeted hERG 3'UTR and was associated with higher survival rates in patients with breast cancer (HR=0.39, 95%CI=0.18-0.82). +other 31658856 hsa-mir-15a Sepsis Conclusion: The miR-15a-5p-XIST-CUL3 regulatory axis was related to the pathogenesis of sepsis-induced AKI. The miR-15a-5p-XIST-CUL3 axis was critical for sepsis-induced AKI. +other 31658856 hsa-mir-15a Acute Kidney Injury Conclusion: The miR-15a-5p-XIST-CUL3 regulatory axis was related to the pathogenesis of sepsis-induced AKI. The miR-15a-5p-XIST-CUL3 axis was critical for sepsis-induced AKI. +other 31658769 hsa-let-7a Varicella Zoster Virus Infection Small RNA sequencing identified that several miRNAs were upregulated, including miR-146a-5p, which has been associated with other herpesvirus infections, whereas let-7a-3p was downregulated in both wildtype and attenuated VZV-infected cells. +other 31658769 hsa-mir-146a Varicella Zoster Virus Infection Small RNA sequencing identified that several miRNAs were upregulated, including miR-146a-5p, which has been associated with other herpesvirus infections, whereas let-7a-3p was downregulated in both wildtype and attenuated VZV-infected cells. +lncRNA target 31658290 hsa-mir-142 Encephalomyelitis, Eastern Equine 3p limits virus replication in myeloid cells and suppresses the systemic innate immune response, greatly exacerbating EEEV neurovirulence. +lncRNA target 31658244 hsa-mir-181a Osteoarthritis CONCLUSIONS Our findings indicate that downregulation of NEAT1 aggravated progression of OA via modulating the miR-181a/GPD1L axis, providing a novel insight into the mechanism of OA pathogenesis. +transcription factor target 31658060 hsa-mir-291 Nerve Degeneration Together, these data suggest that miR-291 has a protective role in neurodegeneration, likely through regulation of ROCK2. +circulation_biomarker_diagnosis_up 31658043 hsa-mir-21 Uterine Cervical Neoplasms 5p levels were all up-regulated in CC tissue specimens, whereas miR-146a-5p, miR-151a-3p, and miR-2110 levels were up-regulated in plasma exosomes. +circulation_biomarker_diagnosis_up 31658043 hsa-mir-151a Uterine Cervical Neoplasms 5p levels were all up-regulated in CC tissue specimens, whereas miR-146a-5p, miR-151a-3p, and miR-2110 levels were up-regulated in plasma exosomes. +circulation_biomarker_diagnosis_up 31658043 hsa-mir-146a Uterine Cervical Neoplasms 5p levels were all up-regulated in CC tissue specimens, whereas miR-146a-5p, miR-151a-3p, and miR-2110 levels were up-regulated in plasma exosomes. +circulation_biomarker_diagnosis_up 31658043 hsa-mir-2110 Uterine Cervical Neoplasms 5p levels were all up-regulated in CC tissue specimens, whereas miR-146a-5p, miR-151a-3p, and miR-2110 levels were up-regulated in plasma exosomes. +other 31658041 hsa-mir-185 Carcinoma, Hepatocellular 5p, miR-23b-3p) were significantly decreased in HCC patients compared to LC patients. +other 31658041 hsa-mir-23b Hepatitis C 5p, miR-23b-3p) were significantly decreased in HCC patients compared to LC patients. +other 31658041 hsa-mir-23b Carcinoma, Hepatocellular 5p, miR-23b-3p) were significantly decreased in HCC patients compared to LC patients. +other 31658041 hsa-mir-185 Hepatitis C 5p, miR-23b-3p) were significantly decreased in HCC patients compared to LC patients. +exosome 31657855 hsa-mir-155 Intracranial Aneurysm In conclusion, TAM-derived exosomal miR +circulation_biomarker_diagnosis_ns 31656724 hsa-mir-124 Ischemic Stroke In conclusion, this study provides strong evidence that serum BDNF and the BDNF-regulatory miR-124 may serve as molecular markers for AIS. +transcription factor target 31656545 hsa-mir-346 Osteosarcoma In the regulatory network, hsa-miR-346 and its target gene, c-FLIP, can be used as biomarkers for an earlier diagnosis of OS. +genetics_overexpression_promote 31656540 hsa-mir-146a Cerebral Hemorrhage Results from further analyses demonstrated that the overexpression of miR-146a inhibited neuronal apoptosis, reduced pro-inflammatory cytokine production and prevented oxidative stress in ICH rats. +genetics_knock down_suppress 31656538 hsa-mir-552 Carcinoma, Hepatocellular miR-552 knockdown also increased HCC cell apoptosis in vitro. +lncRNA target 31656536 hsa-mir-345 Diabetes, Gestational miR3p was identified to be a direct target of lncRNA MEG3 using dual luciferase reporter assay, which was found to be reduced in pregnant women with GDM. +genetics_knock down_promote 31655908 hsa-mir-299 Pancreatic Carcinoma TUG1 knockdown suppressed cell proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT), and induced apoptosis in PC cells, and repressed tumor growth and EMT in PC xenograft models, which were reversed following reintroduction with anti-miR +transcription factor target 31655629 hsa-mir-106b Colorectal Neoplasms Moreover, our investigations showed that PLK3 was directly targeted by miR-106b at post-transcriptional level in CRC cells. +genetics_overexpression_promote 31655310 hsa-mir-148b Carcinoma, Hepatocellular MiR-148b-overexpressing HCC cells were used to investigate the effect of miR-148b in vitro and in vivo. +other 31655195 hsa-mir-21 Fibrosis, Renal However, the association of BMP-7 with miR-21/Smad7 in DN is unknown. These findings suggest that BMP-7 decreases renal fibrosis in DN by regulating miR-21/Smad7 signaling, providing a theoretical basis for the development of novel and effective therapeutic drugs for DN. +other 31655195 hsa-mir-21 Diabetic Nephropathies However, the association of BMP-7 with miR-21/Smad7 in DN is unknown. These findings suggest that BMP-7 decreases renal fibrosis in DN by regulating miR-21/Smad7 signaling, providing a theoretical basis for the development of novel and effective therapeutic drugs for DN. +circulation_biomarker_diagnosis_up 31654716 hsa-mir-181a Pancreatitis ADM3100 exhibited more severe pancreatic injury and decreased miR-181a-5p levels in the pancreas and serum compared to SAP group. +lncRNA target 31654502 hsa-mir-194 high grade glioma Overall, this present study identified the crucial regulation of circ-USP1 on BTB permeability via miR +genetics_knock down_promote 31654502 hsa-mir-194 Tuberculosis 5p contributed to circ-USP1 knockdown-induced increase of BTB permeability via targeting and down-regulating transcription factor FLI1. +other 31654285 hsa-mir-605 Clear-cell metastatic renal cell carcinoma There was higher baseline expression of miR-605 in patients with progressive disease (PD) vs those with stable disease (SD) (p=0.0112). PD patients' miR-605 levels decreased after the 1st cycle (p=0.0245), whereas SD patients' miR-605 levels increased (p=0.0179). +lncRNA target 31654121 hsa-mir-143 Carcinoma, Non-Small-Cell Lung MicroRNA-143 (miR-143) was found to significantly suppress the migration and invasion of NSCLC. +lncRNA target 31653823 hsa-mir-1246 Osteoarthritis RESULTS We found that CAIF in synovial fluid was downregulated in OA patients and inversely correlated with miR-1246 and IL-6. CONCLUSIONS Therefore, CAIF may downregulate miR-1246 to improve OA. +circulation_biomarker_diagnosis_ns 31653266 hsa-mir-132 Diabetes, Gestational CONCLUSION: All the data of this study revealed the reduced expression of miR-132 in serum and placenta tissues of GDM, and serum miR-132 serves a candidate biomarker in the diagnosis of GDM. +other 31652924 hsa-mir-125b Obesity The expression of VDR in VAT of obese subjects correlated negatively with levels of miR-125a-5p (P = 0.0006, r(s) = -0.525), miR-125b-5p (P = 0.001, r(s) = -0.495), and miR3p (P = 0.009, r(s) = -0.379). +other 31652924 hsa-mir-214 Obesity The expression of VDR in VAT of obese subjects correlated negatively with levels of miR-125a-5p (P = 0.0006, r(s) = -0.525), miR-125b-5p (P = 0.001, r(s) = -0.495), and miR3p (P = 0.009, r(s) = -0.379). +other 31652924 hsa-mir-125a Obesity The expression of VDR in VAT of obese subjects correlated negatively with levels of miR-125a-5p (P = 0.0006, r(s) = -0.525), miR-125b-5p (P = 0.001, r(s) = -0.495), and miR3p (P = 0.009, r(s) = -0.379). +other 31652721 hsa-mir-21 pancreatic adenocarcinoma Evidence on equilibrative nucleoside transporter 1 (ENT1) and microRNA-21 (miR21) is not yet sufficiently convincing to consider them as prognostic biomarkers for patients with pancreatic ductal adenocarcinoma (PDAC). +other 31652596 hsa-mir-20a Attention Deficit Disorder with Hyperactivity 5p, let-7b-5p, miR-181a-5p, miR-320a, and miR-148b-3p) and 560 genes were significantly DE in children with ADHD compared to TD subjects. +other 31652596 hsa-let-7b Attention Deficit Disorder with Hyperactivity 5p, let-7b-5p, miR-181a-5p, miR-320a, and miR-148b-3p) and 560 genes were significantly DE in children with ADHD compared to TD subjects. +other 31652596 hsa-mir-148b Attention Deficit Disorder with Hyperactivity 5p, let-7b-5p, miR-181a-5p, miR-320a, and miR-148b-3p) and 560 genes were significantly DE in children with ADHD compared to TD subjects. +other 31652596 hsa-mir-942 Attention Deficit Disorder with Hyperactivity 5p, let-7b-5p, miR-181a-5p, miR-320a, and miR-148b-3p) and 560 genes were significantly DE in children with ADHD compared to TD subjects. +other 31652596 hsa-mir-652 Attention Deficit Disorder with Hyperactivity 5p, let-7b-5p, miR-181a-5p, miR-320a, and miR-148b-3p) and 560 genes were significantly DE in children with ADHD compared to TD subjects. +transcription factor target 31652455 hsa-mir-103 Osteoarthritis CONCLUSIONS: Our studies suggest that miRNA-103 contributes to chondrocyte apoptosis, promoting OA progression by down-regulation of PI3K/AKT pathway through the reduction in SPHK1 activity. +lncRNA target 31652445 hsa-mir-1587 Keloid Expression of miR-1587 and miR-2392 were significantly down-regulated in keloid tissues and HSFBs, while the ZEB2 was a target of both and up-regulated in keloid tissues and HSFBs compared with the normal controls. +lncRNA target 31652445 hsa-mir-2392 Keloid Expression of miR-1587 and miR-2392 were significantly down-regulated in keloid tissues and HSFBs, while the ZEB2 was a target of both and up-regulated in keloid tissues and HSFBs compared with the normal controls. +lncRNA target 31652435 hsa-mir-211 Osteosarcoma MiR-211 was up-regulated in osteosarcoma and negatively correlated with the expression of TUSC7. TUSC7 inhibited the proliferation, migration of osteosarcoma cells and promoted cellular apoptosis, which is largely mediated by miR-211. +lncRNA target 31652309 hsa-mir-204 Stomach Neoplasms In conclusion, BCYRN1 acts as a promising prognostic predictor in GC patients and regulated GC cell proliferation, cell cycle, migration and invasion through targeting miR +other 31651707 hsa-mir-212 Hypoxia-Ischemia, Brain Taken together, our study revealed that the role of miR-212 in the modulation of ischemic brain injury might be achieved by regulating sirtuin 2, which provides potential biomarkers and candidates for the treatment of cerebral ischemia. +other 31651707 hsa-mir-212 Brain Ischemia Taken together, our study revealed that the role of miR-212 in the modulation of ischemic brain injury might be achieved by regulating sirtuin 2, which provides potential biomarkers and candidates for the treatment of cerebral ischemia. +lncRNA target 31651553 hsa-mir-200a Cardiomegaly Jointly, our study suggested that miR-200a-3p facilitated cardiac hypertrophy by not only directly targeting WDR1 but also through modulating PTEN/PI3K/AKT/CREB/WDR1 signaling, therefore proving novel downstream molecular pathway of miR-200a-3p in cardiac hypertrophy. +genetics_overexpression_suppress 31651329 hsa-mir-99b Osteosarcoma OS cell proliferation, migration and invasion can be inhibited by the overexpression of miR-99b, suggesting that the methods to increase miR-99b expression may be novel therapeutic strategies in OS. +other 31651222 hsa-mir-4319 Esophageal Squamous Cell Carcinoma We discovered the interaction of SEMA4D with HuR and miR-4319, whereas the detailed mechanism in ESCC was yet to be researched. Collectively, HuR and miR-4319 co-regulating SEMA4D affected cell proliferation, apoptosis and migration in ESCC. +lncRNA target 31651086 hsa-mir-124 Carcinoma, Hepatocellular 3p and suppressing PIM-1, which may be an effective method in the treatment of HCC. +lncRNA target 31650542 hsa-mir-103a Brain Ischemia Downregulation of microRNA-103a reduces microvascular endothelial cell injury in a rat model of cerebral ischemia by targeting AXIN2. This study highlights that miR-103a targets and negatively regulates AXIN2, whereby reducing BMEC injury in cerebral ischemia. +genetics_knock down_promote 31650535 hsa-mir-665 Stomach Neoplasms Overexpression of miR-665 promoted, whereas knockdown of miR-665 suppressed the proliferation, migration, and EMT of gastric adenocarcinoma cells. +lncRNA target 31650323 hsa-mir-1273 Stomach Neoplasms The levels of miR-1273h-5p showed an inverse correlation with COL1A1-014 and CXCL12 in GC cells transfected with miR-1273h-5p. CONCLUSIONS: These findings demonstrated that COL1A1-014 play an important regulatory role in GC development by functioning as a ceRNA in regulating the CXCL12/CXCR4 axis via sponging miR-1273h-5p. +lncRNA target 31650028 hsa-mir-497 Carcinoma, Hepatocellular We discover that miR-497 directly targets SALL4, negatively regulates its expression, and further inhibits the self-renewal and metastasis of HCC; more importantly, inflammatory factor TNF-alpha inhibits the expression of miR-497 via NF-kB-mediated negative transcriptional regulation and simultaneously upregulates the expression of SALL4 and promotes the self-renewal and metastasis phenotypes of HCC cells. +transcription factor target 31650021 hsa-mir-8064 Colorectal Neoplasms Taken together, our data suggest that OCT4B1 may be involved in regulating the self-renewal of colorectal CSCs through EMT, which is at least partially due to the miR-8064/PLK1 balance. +lncRNA target 31649850 hsa-mir-630 Carcinoma, Renal Cell 3p and miR-630 function as oncotherapy-obstructing microRNAs by directly targeting OCT2 in RCC. +other 31649487 hsa-mir-326 Carcinoma, Squamous Cell, Cutaneous CONCLUSIONS: These results present that HOTAIR, as a ceRNA, regulates PRAF2 expression by competitive binding to miR-326 during CSCC. +lncRNA target 31649243 hsa-mir-135b Triple Negative Breast Neoplasms 5p) and 3 hub genes (FOXC1, FAM171A1, RGMA) as specific prognostic biomarkers and promising therapeutic targets for TNBC. +lncRNA target 31649243 hsa-mir-9 Triple Negative Breast Neoplasms 5p) and 3 hub genes (FOXC1, FAM171A1, RGMA) as specific prognostic biomarkers and promising therapeutic targets for TNBC. +lncRNA target 31649118 hsa-mir-449a Breast Neoplasms Tumor-suppressive microRNA-449a and microRNA-34a (miR-449a/34a) were recently reported to inhibit breast cancer cell migration and invasion via targeting TPD52. +genetics_overexpression_promote 31649116 hsa-mir-145 Hepatopulmonary Syndrome In addition, overexpression of miR +genetics_overexpression_promote 31649116 hsa-mir-145 Hypertension, Pulmonary In addition, overexpression of miR +genetics_GWAS 31648633 hsa-mir-206 Esophageal Neoplasms CONCLUSION: This study explored the unique genomic and epigenetic landscape associated with the expression of miR-206, provided evidence of mir-206 as a prognostic biomarker or a potential therapeutic target for EC patients. +genetics_overexpression_promote 31648497 hsa-mir-23a Leukemia, Myeloid, Acute Overexpression of miR-23a-3p inhibited caspase-3 activity in U937 cells (3.64+/-0.56)%, P<0.01, while up-regulation of SMC1A promoted caspase-3 activity in U937 cells (15.29+/-0.85)%, P<0.01. +genetics_overexpression_promote 31648465 hsa-mir-214 Hyperglycemia In order to further verify the anti-pyroptosis effect of miR-214 was mediated by targeted inhibition on caspase-1, cells overexpressing caspase-1 were used in the rescue experiment. +genetics_overexpression_promote 31648465 hsa-mir-214 Syphilis In order to further verify the anti-pyroptosis effect of miR-214 was mediated by targeted inhibition on caspase-1, cells overexpressing caspase-1 were used in the rescue experiment. +other 31648231 hsa-mir-93 Mycosis Fungoides The aim of the present study was to characterize the expression of microRNA-16 (miR-16) and microRNA-93 (miR-93) in early and advanced cases of MF in relation to the clinicopathological parameters. Ten skin biopsies of early and advanced MF were investigated for the expression of miR-16 and miR-93 using RT-PCR. +lncRNA target 31648165 hsa-mir-34a Precancerous Conditions To be fully evidenced, RT-qPCR, Western blot and immunohistochemistry were used to detect the expressions of LDHA, CD147, HIF-1alpha, MCT4, PI3K, AKT, mTOR and miRNA-34a, which were crucial factors for evaluating GPL in the aspect of glycolysis pathogenesis. In brief, the findings of this study imply that abnormal glycolysis in MNNG-induced GPL rats was relieved by WPX decoction via regulation of the expressions of LDHA, CD147, HIF-1alpha, MCT4, PI3K, AKT, mTOR and miRNA-34a. +genetics_overexpression_promote 31648164 hsa-mir-383 Carcinoma, Hepatocellular Furthermore, overexpression of miR-383 suppressed cell proliferation and promoted apoptosis in hepatocellular carcinoma. +other 31648104 hsa-mir-199a Glioblastoma Blocking the MALAT1/miR-199a/ZHX1 axis can serve as a novel therapeutic strategy for treating GBM. +circRNA target 31648103 hsa-mir-1236 Colorectal Neoplasms In conclusion, these data suggest that circIFT80 is a central component linking circRNAs to the progression of CRC via a miR +transcription factor target 31647949 hsa-mir-150 Coronary Restenosis Collectively, these results suggested that miR-150 may act as a novel therapeutic target for arterial restenosis. +transcription factor target 31647949 hsa-mir-150 Endometrial Hyperplasia Collectively, these results suggested that miR-150 may act as a novel therapeutic target for arterial restenosis. +circRNA target 31647948 hsa-mir-296 Carcinoma, Non-Small-Cell Lung SIGNIFICANCE: Our present study illustrated that circ_0076305 regulated STAT3 expression and DDP resistance of NSCLC cells via sponging miR +other 31647206 hsa-mir-99a Carcinoma, Basal Cell mRNA sequencing revealed S100A9, KRT14, KRT10, S100A8, S100A7, COX1, KRT1, COX3, and smallRNA sequencing analysis miR-21, miR-99a, miR26-a-2, let-7f, let-7g, let-7i, miR-100, and miR-205 were the most strongly expressed in sBCCs. +other 31647206 hsa-mir-205 Carcinoma, Basal Cell mRNA sequencing revealed S100A9, KRT14, KRT10, S100A8, S100A7, COX1, KRT1, COX3, and smallRNA sequencing analysis miR-21, miR-99a, miR26-a-2, let-7f, let-7g, let-7i, miR-100, and miR-205 were the most strongly expressed in sBCCs. +other 31647206 hsa-let-7i Carcinoma, Basal Cell mRNA sequencing revealed S100A9, KRT14, KRT10, S100A8, S100A7, COX1, KRT1, COX3, and smallRNA sequencing analysis miR-21, miR-99a, miR26-a-2, let-7f, let-7g, let-7i, miR-100, and miR-205 were the most strongly expressed in sBCCs. +other 31647206 hsa-let-7g Carcinoma, Basal Cell mRNA sequencing revealed S100A9, KRT14, KRT10, S100A8, S100A7, COX1, KRT1, COX3, and smallRNA sequencing analysis miR-21, miR-99a, miR26-a-2, let-7f, let-7g, let-7i, miR-100, and miR-205 were the most strongly expressed in sBCCs. +other 31647206 hsa-let-7f Carcinoma, Basal Cell mRNA sequencing revealed S100A9, KRT14, KRT10, S100A8, S100A7, COX1, KRT1, COX3, and smallRNA sequencing analysis miR-21, miR-99a, miR26-a-2, let-7f, let-7g, let-7i, miR-100, and miR-205 were the most strongly expressed in sBCCs. +other 31647206 hsa-mir-26a-2 Carcinoma, Basal Cell mRNA sequencing revealed S100A9, KRT14, KRT10, S100A8, S100A7, COX1, KRT1, COX3, and smallRNA sequencing analysis miR-21, miR-99a, miR26-a-2, let-7f, let-7g, let-7i, miR-100, and miR-205 were the most strongly expressed in sBCCs. +other 31647206 hsa-mir-21 Carcinoma, Basal Cell mRNA sequencing revealed S100A9, KRT14, KRT10, S100A8, S100A7, COX1, KRT1, COX3, and smallRNA sequencing analysis miR-21, miR-99a, miR26-a-2, let-7f, let-7g, let-7i, miR-100, and miR-205 were the most strongly expressed in sBCCs. +transcription factor target 31647062 hsa-mir-200c Kidney Diseases Here, a novel hairpin DNA-fueled nanoflare was developed for the simultaneous detection of drug-induced nephrotoxicity-related miRNA-21 and miRNA-200c with target catalytic recycling amplification. Our hairpin DNA-fueled nanoflare could also accurately detect the divergence of miRNA-21 and miRNA-200c between drug-treated nephrotoxic cells and tumor cells, demonstrating a promising potential for exploring the pathogenesis of drugs and auxiliary diagnosis of drug-induced nephrotoxicity. +transcription factor target 31647062 hsa-mir-21 Kidney Diseases Here, a novel hairpin DNA-fueled nanoflare was developed for the simultaneous detection of drug-induced nephrotoxicity-related miRNA-21 and miRNA-200c with target catalytic recycling amplification. Our hairpin DNA-fueled nanoflare could also accurately detect the divergence of miRNA-21 and miRNA-200c between drug-treated nephrotoxic cells and tumor cells, demonstrating a promising potential for exploring the pathogenesis of drugs and auxiliary diagnosis of drug-induced nephrotoxicity. +circulation_biomarker_diagnosis_ns 31646977 hsa-mir-21 Uterine Cervical Diseases CONCLUSIONS: Changes in plasma miRNA-21, - 214, -34a and -200a levels were associated with cervical lesion severity. +other 31646911 hsa-mir-489 Implantation Failure In the miRNA-TF-DEGs network, E2F4, SIN3A, miRNA489, miRNA199A, miRNA369-3P, miRNA422, and miRNA522 were considered as the key regulatory factors during RIF. +other 31646911 hsa-mir-369 Renal Interstitial Fibrosis In the miRNA-TF-DEGs network, E2F4, SIN3A, miRNA489, miRNA199A, miRNA369-3P, miRNA422, and miRNA522 were considered as the key regulatory factors during RIF. +other 31646911 hsa-mir-369 Implantation Failure In the miRNA-TF-DEGs network, E2F4, SIN3A, miRNA489, miRNA199A, miRNA369-3P, miRNA422, and miRNA522 were considered as the key regulatory factors during RIF. +other 31646911 hsa-mir-199a Renal Interstitial Fibrosis In the miRNA-TF-DEGs network, E2F4, SIN3A, miRNA489, miRNA199A, miRNA369-3P, miRNA422, and miRNA522 were considered as the key regulatory factors during RIF. +other 31646911 hsa-mir-489 Renal Interstitial Fibrosis In the miRNA-TF-DEGs network, E2F4, SIN3A, miRNA489, miRNA199A, miRNA369-3P, miRNA422, and miRNA522 were considered as the key regulatory factors during RIF. +other 31646911 hsa-mir-199a Implantation Failure In the miRNA-TF-DEGs network, E2F4, SIN3A, miRNA489, miRNA199A, miRNA369-3P, miRNA422, and miRNA522 were considered as the key regulatory factors during RIF. +circulation_biomarker_diagnosis_up 31646827 hsa-mir-146a Prostatic Neoplasms CONCLUSION: The expression level of miR-146a showed a trend of up-regulation in prostate cancer, and the expression level of miR-152 had a trend of down-regulation in prostate cancer, and the results of partial correlation analysis showed that the expression level of miR-146a and miR-152 was negatively correlated with each other in the serum of the patients with prostate cancer. +circulation_biomarker_diagnosis_up 31646827 hsa-mir-152 Prostatic Neoplasms CONCLUSION: The expression level of miR-146a showed a trend of up-regulation in prostate cancer, and the expression level of miR-152 had a trend of down-regulation in prostate cancer, and the results of partial correlation analysis showed that the expression level of miR-146a and miR-152 was negatively correlated with each other in the serum of the patients with prostate cancer. +lncRNA target 31646811 hsa-mir-489 Pancreatic Carcinoma CONCLUSIONS: Our findings indicate that up-regulation of miR-489 could suppress PC cell proliferation and facilitate cell apoptosis through targeting AKT3. +other 31646803 hsa-mir-335 Triple Negative Breast Neoplasms CONCLUSION: The expression level of miR-335 in cancer tissues of TNBC patients is lower than that in adjacent tissues. +lncRNA target 31646760 hsa-mir-381 Prostatic Neoplasms Altogether, our findings provide a strong rationale for the clinical application of ICT as a potential oncotherapeutic agent against PCa via a novel molecular mechanism of regulating the miR +circulation_biomarker_prognosis_up 31646712 hsa-mir-338 Esophageal Squamous Cell Carcinoma 5p can modulate 5-FU chemoresistance and inhibit invasion-related functions in ESCC by negatively regulating Id-1, and that serum miR +lncRNA target 31646607 hsa-mir-373 Osteoarthritis 3p/SOX4 axis, providing an effective therapeutic target for osteoarthritis. +circRNA target 31646606 hsa-mir-217 Hepatoblastoma CONCLUSIONS: Mechanically, hsa_circ_0000594 was identified to have a critical role in HB development through the hsa_circ_0000594/mir-217/SIRT1 regulatory axis, which might become a novel diagnostic marker and potential therapeutic target in HB. +circulation_biomarker_diagnosis_ns 31646601 hsa-mir-17 Atherosclerosis 5p in AS serum samples and THP-1 macrophage-derived foam cells; the correlations were also analyzed. +genetics_overexpression_promote 31646592 hsa-mir-133a Myocardial Infarction, Acute CONCLUSIONS: Overexpression of miR-133a down-regulates the mRNA and protein levels of TGF-beta1 and CTGF after myocardial infarction. +genetics_knock down_suppress 31646589 hsa-mir-449 Myocardial Infarction, Acute CONCLUSIONS: Knockdown of lncRNA XIST can repress the myocardial cell apoptosis in AMI model rats by downregulating miR-449 level. +lncRNA target 31646586 hsa-mir-367 Coronary Disease The downregulation of linc00961 contributed to promote proliferation and inhibit apoptosis of VSMCs by sponging miR-367 in CHD patients, which might provide a potential target for treating atherosclerosis. +lncRNA target 31646584 hsa-mir-132 Alzheimer Disease MicroRNA-132 promotes neurons cell apoptosis and activates Tau phosphorylation by targeting GTDC-1 in Alzheimer's disease. +genetics_overexpression_promote 31646577 hsa-mir-409 Leukemia, Myelogenous, Chronic, BCR-ABL Positive 5p overexpression enhances Imatinib resistance in CML. +lncRNA target 31646574 hsa-mir-214 Breast Neoplasms CONCLUSIONS: TSLNC8 was found to inhibit the proliferation and G1/S phase transition of breast cancer cells, an effect mediated by miR +lncRNA target 31646573 hsa-mir-486 Thyroid Cancer, Papillary Moreover, miR-486 restoration in PTC cells was confirmed to markedly inhibit proliferation, invasion, and migration via the regulation of extracellular-signal-regulated kinase (ERK) and protein kinase B (Akt) signaling pathways and epithelial-mesenchymal transition (EMT). +genetics_overexpression_suppress 31646571 hsa-mir-381 Adenocarcinoma of Lung Furthermore, miR-381 overexpression affected the PI3K/Akt pathway and EMT in LA. +lncRNA target 31646570 hsa-mir-1224 Lung Neoplasms However, the upregulation of the expression of miR-1224 level could significantly inhibit proliferation and promote the apoptosis rate of lung cancer cells. +genetics_knock down_promote 31646569 hsa-mir-212 Small Cell Lung Carcinoma CONCLUSIONS: XIST was significantly decreased in NSCLC tissues and cells, and XIST knockdown suppressed the proliferation, migration, invasion and EMT of NSCLC cells by miR +circulation_biomarker_diagnosis_down 31646564 hsa-mir-98 Colorectal Neoplasms CONCLUSIONS: Collectively, serum miR-98 might be useful as an indicator for predicting the clinical outcome of CRC patients. +genetics_overexpression_promote 31646563 hsa-mir-372 Colorectal Neoplasms Interestingly, the overexpression of LATS2 partially reversed the miR +lncRNA target 31646561 hsa-mir-149 Colorectal Neoplasms 3p reversed the suppressive effects of PCAT-1 on the cell growth of CRC cells. +genetics_overexpression_promote 31646555 hsa-mir-125a Ovarian Neoplasms PATIENTS AND METHODS: The human ovarian cancer cells were cultured, and miR-125a-5p was repressed by inhibitor and overexpressed by miRNA mimics. +lncRNA target 31646552 hsa-mir-15a Uterine Cervical Neoplasms Our results clearly suggested that the down-regulation of TP53INP1 successfully impaired the tumor-inhibition effects of miR-15a-5p inhibitor in cervical cancer cells. +genetics_overexpression_promote 31646550 hsa-mir-183 Osteosarcoma Overexpression of AKT could abolish the inhibitory effect of microRNA +lncRNA target 31646548 hsa-mir-421 Arthritis, Rheumatoid RESULTS: MicroRNA-421 was highly expressed in the synovial tissues of RA patients. +genetics_overexpression_promote 31646380 hsa-mir-129 Cardiomegaly Overexpression of HMGB1 diminished the effects of miR +genetics_GWAS 31646336 hsa-mir-1983 Leukemia, Myeloid, Acute Importantly, a significant decrease in Sfpi1 gene expression is found almost exclusively in rAML samples without an Sfpi1 R235 mutation and is specifically associated with up-regulation of mir-1983 and mir5p. +genetics_GWAS 31646336 hsa-mir-582 Leukemia, Myeloid, Acute Importantly, a significant decrease in Sfpi1 gene expression is found almost exclusively in rAML samples without an Sfpi1 R235 mutation and is specifically associated with up-regulation of mir-1983 and mir5p. +transcription factor target 31645844 hsa-mir-494 Breast Neoplasms Therefore, miR-494 might be considered as a novel therapeutic target for the management of human breast cancer. +genetics_knock down_promote 31645843 hsa-mir-30 Leukemia, Myeloid Knockdown of RPPH1 suppressed the proliferation, invasion and migration ability of human AML cells, which was partially reversed by additional administration with miR +genetics_knock down_promote 31645843 hsa-mir-30 Ischemic Stroke Knockdown of RPPH1 suppressed the proliferation, invasion and migration ability of human AML cells, which was partially reversed by additional administration with miR +genetics_knock down_suppress 31645540 hsa-mir-155 Carcinoma, Hepatocellular The knockdown of PTEN attenuated the proliferation of HCC cells treated with the exosomal miR-155. +lncRNA target 31645479 hsa-mir-2052 Carcinoma, Hepatocellular Furthermore, HULC inhibits miR-2052, thereby stimulating MET expression in HCC. +genetics_knock down_promote 31645142 hsa-mir-223 autoimmune uveitis Knockdown of miR +genetics_knock down_promote 31645142 hsa-mir-223 Uveitis Knockdown of miR +other 31645091 hsa-mir-374a Adenocarcinoma of Lung CONCLUSIONS miR-374a expression may serve as a potential prognostic biomarker for predicting recurrence in early stage lung adenocarcinoma after curative surgery. +other 31645091 hsa-mir-374 Adenocarcinoma of Lung CONCLUSIONS miR-374a expression may serve as a potential prognostic biomarker for predicting recurrence in early stage lung adenocarcinoma after curative surgery. +genetics_overexpression_promote 31645082 hsa-mir-103a Ovarian Neoplasms Altogether, the current study demonstrates that overexpressed EPB41L4A-AS2 can potentially bind to miR-103a to promote the expression of RUNX1T1, thereby inhibiting OC, highlighting the potential of EPB41L4A-AS2 as a target for OC. +lncRNA target 31645055 hsa-mir-676 Neuroblastoma CONCLUSION: CASC11 sequestered miR3p from NOL4L to facilitate neonatal neuroblastoma progression, hinting a CASC11-mediated therapeutic target for neonatal neuroblastoma. +other 31644912 hsa-mir-27a Multiple Sclerosis Increased levels of miR-27a were found in OPCs associated with multiple sclerosis (MS) lesions and in animal models of demyelination. +other 31644912 hsa-mir-27a Demyelinating Diseases Increased levels of miR-27a were found in OPCs associated with multiple sclerosis (MS) lesions and in animal models of demyelination. +lncRNA target 31644316 hsa-mir-619 Thyroid Cancer, Papillary 5p/FOXM1 positive feedback loop regulated cell proliferation and apoptosis in TC, shedding a light on the molecular target identification and promising treatment improvement in TC. +lncRNA target 31643121 hsa-mir-212 Pituitary Neoplasms In summary, reduced miR-212 expression in PA contributed to abnormal cancer cell proliferation and invasion mainly by targeting c-Met. +other 31643088 hsa-mir-199a Inflammation This was further supported by the downregulation of myomiRs associated with a muscle injury and inflammation (miR-199a and miR-223) during hibernation. +lncRNA target 31643088 hsa-mir-29 Muscular Atrophy This study identified myomiR-mediated mechanisms for the promotion of muscle regeneration, suppression of ubiquitin ligases, and resistance to muscle atrophy during hibernation mediated by observed increases in miR-206, miR-221, miR-31, miR-23a, and miR-29b. +lncRNA target 31643088 hsa-mir-206 Muscular Atrophy This study identified myomiR-mediated mechanisms for the promotion of muscle regeneration, suppression of ubiquitin ligases, and resistance to muscle atrophy during hibernation mediated by observed increases in miR-206, miR-221, miR-31, miR-23a, and miR-29b. +lncRNA target 31643088 hsa-mir-23a Muscular Atrophy This study identified myomiR-mediated mechanisms for the promotion of muscle regeneration, suppression of ubiquitin ligases, and resistance to muscle atrophy during hibernation mediated by observed increases in miR-206, miR-221, miR-31, miR-23a, and miR-29b. +lncRNA target 31643088 hsa-mir-23a Atrophy This study identified myomiR-mediated mechanisms for the promotion of muscle regeneration, suppression of ubiquitin ligases, and resistance to muscle atrophy during hibernation mediated by observed increases in miR-206, miR-221, miR-31, miR-23a, and miR-29b. +lncRNA target 31643088 hsa-mir-29 Atrophy This study identified myomiR-mediated mechanisms for the promotion of muscle regeneration, suppression of ubiquitin ligases, and resistance to muscle atrophy during hibernation mediated by observed increases in miR-206, miR-221, miR-31, miR-23a, and miR-29b. +lncRNA target 31643088 hsa-mir-206 Atrophy This study identified myomiR-mediated mechanisms for the promotion of muscle regeneration, suppression of ubiquitin ligases, and resistance to muscle atrophy during hibernation mediated by observed increases in miR-206, miR-221, miR-31, miR-23a, and miR-29b. +lncRNA target 31643088 hsa-mir-1 Muscular Atrophy This study identified myomiR-mediated mechanisms for the promotion of muscle regeneration, suppression of ubiquitin ligases, and resistance to muscle atrophy during hibernation mediated by observed increases in miR-206, miR-221, miR-31, miR-23a, and miR-29b. +lncRNA target 31643088 hsa-mir-1 Atrophy This study identified myomiR-mediated mechanisms for the promotion of muscle regeneration, suppression of ubiquitin ligases, and resistance to muscle atrophy during hibernation mediated by observed increases in miR-206, miR-221, miR-31, miR-23a, and miR-29b. +lncRNA target 31643088 hsa-mir-221 Muscular Atrophy This study identified myomiR-mediated mechanisms for the promotion of muscle regeneration, suppression of ubiquitin ligases, and resistance to muscle atrophy during hibernation mediated by observed increases in miR-206, miR-221, miR-31, miR-23a, and miR-29b. +other 31643088 hsa-mir-223 Muscular Diseases This was further supported by the downregulation of myomiRs associated with a muscle injury and inflammation (miR-199a and miR-223) during hibernation. +other 31643088 hsa-mir-223 Inflammation This was further supported by the downregulation of myomiRs associated with a muscle injury and inflammation (miR-199a and miR-223) during hibernation. +lncRNA target 31643088 hsa-mir-29b Muscular Atrophy This study identified myomiR-mediated mechanisms for the promotion of muscle regeneration, suppression of ubiquitin ligases, and resistance to muscle atrophy during hibernation mediated by observed increases in miR-206, miR-221, miR-31, miR-23a, and miR-29b. +lncRNA target 31643088 hsa-mir-221 Atrophy This study identified myomiR-mediated mechanisms for the promotion of muscle regeneration, suppression of ubiquitin ligases, and resistance to muscle atrophy during hibernation mediated by observed increases in miR-206, miR-221, miR-31, miR-23a, and miR-29b. +other 31643088 hsa-mir-199a Muscular Diseases This was further supported by the downregulation of myomiRs associated with a muscle injury and inflammation (miR-199a and miR-223) during hibernation. +lncRNA target 31643088 hsa-mir-29b Atrophy This study identified myomiR-mediated mechanisms for the promotion of muscle regeneration, suppression of ubiquitin ligases, and resistance to muscle atrophy during hibernation mediated by observed increases in miR-206, miR-221, miR-31, miR-23a, and miR-29b. +genetics_overexpression_promote 31643078 hsa-mir-16 Pre-Eclampsia Our study highlights that overexpression of miR-16 is involved in PE by regulating the biological functions of trophoblast cells via inhibition of Notch2. +other 31643074 hsa-mir-375 Colorectal Neoplasms In colorectal carcinoma cells, replication and cytotoxicity of both viruses were slightly reduced compared to rCVB3.1, but less pronounced for the 3'-miR-375TS virus. +other 31643074 hsa-mir-375 Pancreatic Diseases Thus, CVB3 with miR-375TS in the 3'UTR of the viral genome may be suitable to avoid pancreatic toxicity. +lncRNA target 31643074 hsa-mir-375 Alcohol Withdrawal Delirium Here, we inserted target sequences of the microRNA miR-375 (miR-375TS) into the 5' terminus of the polyprotein encoding sequence or into the 3'UTR of the CVB3 strain rCVB3.1 to prevent viral replication in the pancreas. +circulation_biomarker_diagnosis_up 31643031 hsa-mir-744 Liver Cirrhosis RESULTS: The levels of serum microRNA (miR)-744 is inversely correlated with the severity of LC and is a reliable biomarker of LC. +other 31642613 hsa-mir-99a Uterine Cervical Neoplasms In conclusion, a total of four DEGs (TYMS, SASH1, CDK1 and AURKA) and two DEmiRNAs (hsa-miR-21 and hsa-miR-99a) may be involved in the pathogenesis of CIN and the progression of CIN into CSCC. +other 31642613 hsa-mir-21 Uterine Cervical Neoplasms In conclusion, a total of four DEGs (TYMS, SASH1, CDK1 and AURKA) and two DEmiRNAs (hsa-miR-21 and hsa-miR-99a) may be involved in the pathogenesis of CIN and the progression of CIN into CSCC. +circulation_biomarker_diagnosis_up 31642612 hsa-mir-1231 Pancreatic Carcinoma The exosomal miR-1231 of peripheral blood may also be a potential indicator for PC diagnosis in the future. +genetics_knock down_promote 31642563 hsa-mir-130a Osteoarthritis, Knee Moreover, the cartilaginous expression of miR-130a-3p was notably reduced in the OA resection regions of KOA patients. Overall, our data revealed that aberrantly high expression of HOTAIR resulted in massive apoptosis events caused by the sponging of miR-130a-3p to suppress autophagy in chondrocytes, which, in turn, might trigger KOA. +genetics_GWAS 31642395 hsa-mir-559 Breast Neoplasms We hypothesized a link between miR-559 SNP rs58450758 and breast cancer.Materials & methods: Bioinformatics analyses were performed to predict the miR-559 target genes and the effect of the rs58450758 SNP on the stem-loop structure. Bioinformatics analyses suggested that rs58450758 changes miR-559 secondary structure and forms new DICER sites in the pre-miRNA.Conclusion: The miR-559 rs58450758 variant is linked to breast cancer. +lncRNA target 31642316 hsa-mir-326 Silicotuberculosis In conclusion, we demonstrate that miR-326 inhibits inflammation and promotes autophagy activity by targeting TNFSF14 and PTBP1 separately to alleviate silica-induced pulmonary fibrosis. +lncRNA target 31642110 hsa-mir-424 Osteosarcoma CONCLUSION: Circ-LARP4 high expression correlates with decreased Enneking stage and prolonged survival profiles, and it elevates chemosensitivity to cisplatin and doxorubicin via sponging miR-424 in osteosarcoma. +lncRNA target 31641848 hsa-mir-29b Carcinoma, Basal Cell Furthermore, by integrating network interaction construction, we found 37 important dysregulated genes (ING3, VEGFA, TP63, MMP11, NRP1, HIF1A, APC, PTCH1, etc.) that are significantly associated with BCC, as well as a few novel potential miRNAs (miR-203, miR-29b, miR-141, miR-7b, miR-9, miR-200a, miR-7c and miR-132) and TFs (MYB, MYC, STAT3, ARNT, PAX5, CUX1, E2F1 and CEBPA). +lncRNA target 31641848 hsa-mir-203 Carcinoma, Basal Cell Furthermore, by integrating network interaction construction, we found 37 important dysregulated genes (ING3, VEGFA, TP63, MMP11, NRP1, HIF1A, APC, PTCH1, etc.) that are significantly associated with BCC, as well as a few novel potential miRNAs (miR-203, miR-29b, miR-141, miR-7b, miR-9, miR-200a, miR-7c and miR-132) and TFs (MYB, MYC, STAT3, ARNT, PAX5, CUX1, E2F1 and CEBPA). +other 31641385 hsa-mir-424 Cholangiocarcinoma 5p, together with peroxisome proliferator-activated receptors, may also have important roles in the pathogenesis of CCA. +other 31641385 hsa-mir-16 Cholangiocarcinoma 5p, together with peroxisome proliferator-activated receptors, may also have important roles in the pathogenesis of CCA. +circulation_biomarker_prognosis_up 31641384 hsa-mir-484 Carcinoma, Non-Small-Cell Lung In summary, the results of the present study demonstrated that increased serum miR-484 expression is associated with the diagnosis and prognosis of patients with NSCLC. +genetics_overexpression_promote 31641382 hsa-mir-454 Glioma Overexpression of EGR3 in glioma cells was found to impair miR +other 31641376 hsa-mir-96 Carcinoma, Hepatocellular The present study revealed that a LINC01093/miR5p/ZFAND5/NF-kappaB signaling axis may have an important role in the pathogenesis of HCC, and further investigation of this axis may provide novel insight into the development and progression of HCC. +genetics_knock down_promote 31640854 hsa-mir-205 Ovarian Neoplasms The biological functions of LINC01133, miR-205, and leucine-rich repeat kinase 2 (LRRK2) were validated on cell proliferation, migration, and invasion of ovarian cancer through gain-of-function and loss-of-function experiments. +genetics_knock down_promote 31640853 hsa-mir-107 Uterine Cervical Neoplasms Cell proliferation, migration, invasion, and EMT in vitro were inhibited as a result of lentiviral-mediated LINC00467 knockdown and miR-107 overexpression in cervical cancer. +other 31640796 hsa-mir-22 Carcinoma, Hepatocellular The upstream regulator of Gal-1, miR-22 was observed to be underexpressed in HCC tissues and negatively correlated with Gal-1. +genetics_overexpression_promote 31640760 hsa-mir-802 Carcinoma, Ovarian Epithelial YWHAZ can partly eliminate the inhibitory effect caused by overexpression of miR-802 on growth and metastasis of epithelial ovarian cancer cells. +other 31640738 hsa-mir-13b Opitz GBBB Syndrome, X-Linked For the miRNA-13b, a statistical correlation was observed between high miRNA-130b expression and poor OS in patients with cancer (HR = 1.95, 95% CI: 1.47-2.59, P < 0.001), especially in tissue sample (HR = 2.01, 95% CI: 1.39-2.91, P < 0.001), Asian (HR = 2.55, 95% Cl: 1.77-3.69, P < 0.001) and hepatocellular carcinoma (HR = 1.87, 95% CI: 1.23-2.85, P = 0.004). +circulation_biomarker_diagnosis_ns 31640738 hsa-mir-130b Carcinoma, Hepatocellular The expression of miRNA-130b was significantly correlated with DFS/PFS (HR = 1.53, 95% CI: 1.31-1.77, P < 0.001), in tissue (HR = 1.98, 95% CI: 1.50-2.62, P < 0.001) and serum (HR = 1.37, 95% CI: 1.15-1.64, P < 0.001), especially in HCC (HR = 1.98, 95% CI: 1.50, 2.62, P < 0.001). +circulation_biomarker_diagnosis_ns 31640738 hsa-mir-130a Opitz GBBB Syndrome, X-Linked Tissue and serum expression of miRNA-130a was significantly associated with the OS (HR = 1.54, 95% CI: 1.11-2.14, P = 0.009; HR = 1.65, 95% CI: 1.14-2.38, P = 0.008), and in gastric cancer (HR = 1.81, 95% CI: 1.34-2.45, P < 0.001). +circulation_biomarker_diagnosis_ns 31640738 hsa-mir-130a hereditary diffuse gastric cancer Tissue and serum expression of miRNA-130a was significantly associated with the OS (HR = 1.54, 95% CI: 1.11-2.14, P = 0.009; HR = 1.65, 95% CI: 1.14-2.38, P = 0.008), and in gastric cancer (HR = 1.81, 95% CI: 1.34-2.45, P < 0.001). +circulation_biomarker_diagnosis_ns 31640738 hsa-mir-130a Carcinoma, Hepatocellular The expression of miRNA-130b was significantly correlated with DFS/PFS (HR = 1.53, 95% CI: 1.31-1.77, P < 0.001), in tissue (HR = 1.98, 95% CI: 1.50-2.62, P < 0.001) and serum (HR = 1.37, 95% CI: 1.15-1.64, P < 0.001), especially in HCC (HR = 1.98, 95% CI: 1.50, 2.62, P < 0.001). +other 31640738 hsa-mir-13b Carcinoma, Hepatocellular For the miRNA-13b, a statistical correlation was observed between high miRNA-130b expression and poor OS in patients with cancer (HR = 1.95, 95% CI: 1.47-2.59, P < 0.001), especially in tissue sample (HR = 2.01, 95% CI: 1.39-2.91, P < 0.001), Asian (HR = 2.55, 95% Cl: 1.77-3.69, P < 0.001) and hepatocellular carcinoma (HR = 1.87, 95% CI: 1.23-2.85, P = 0.004). +other 31640738 hsa-mir-130b Opitz GBBB Syndrome, X-Linked In database test, a significant correlation between high miRNA-130b expression and poor OS for HCC patients was observed (HR = 1.55, 95% CI: 1.01, 2.35, P = 0.0045). +transcription factor target 31640463 hsa-mir-1954 Cardiomyopathies Conclusions Our findings provide evidence, for the first time, that miR-1954 plays a critical role in cardiac fibrosis by targeting THBS1. +transcription factor target 31640463 hsa-mir-1954 Pulmonary Fibrosis Conclusions Our findings provide evidence, for the first time, that miR-1954 plays a critical role in cardiac fibrosis by targeting THBS1. +transcription factor target 31639865 hsa-mir-214 Osteoporosis MiR-214 was reported to regulate the process of osteogenesis and is considered a biomarker of osteoporosis. Collectively, our results indicated that miR-214 could attenuate the osteogenic effects of mechanical loading on osteoblasts, suggesting that inhibition of miR-214 may be one of the ways in which exercise prevents osteoporosis. +circulation_biomarker_diagnosis_up 31639589 hsa-mir-122 Fatty Liver n-6 group developed hepatic steatosis with reduced hepatic reflected as higher plasma microRNA-122 (P<.04) that targets pAMPK. +transcription factor target 31639479 hsa-mir-130a Atherosclerosis Thus, miR-130a-3p may be a potential target for DVT treatment. +transcription factor target 31639479 hsa-mir-130a Venous Thrombosis Thus, miR-130a-3p may be a potential target for DVT treatment. +other 31639426 hsa-mir-186 Sarcoma, Ewing Notably, high levels of miR-186 and low levels of TWIST1 correlate with better prognosis in ES patients. +other 31639228 hsa-mir-494 Cervical Spondylomyelopathy Quantitative real-time PCR was performed to validate the expression levels of 2 miRNAs (miR-494 and miR-612), and we found a 1.5-fold increase in miR-494 expression and a 1.2-fold decrease in miR-612 in the CSF of the OA-CSM affected group (P = .41 and .89, respectively). +other 31639228 hsa-mir-612 Cervical Spondylomyelopathy Quantitative real-time PCR was performed to validate the expression levels of 2 miRNAs (miR-494 and miR-612), and we found a 1.5-fold increase in miR-494 expression and a 1.2-fold decrease in miR-612 in the CSF of the OA-CSM affected group (P = .41 and .89, respectively). +other 31639010 hsa-mir-6126 Autism Spectrum Disorder We identified miR-6126 as being robustly down-regulated in ASD and correlated with the severity of social deficits. +transcription factor target 31638991 hsa-mir-335 Carcinoma, Non-Small-Cell Lung 5p significantly inhibited TGF-beta1-mediated NSCLC migration and invasion. +genetics_overexpression_promote 31638931 hsa-mir-101 Multiple Myeloma Furthermore, overexpression of miR +genetics_overexpression_suppress 31638916 hsa-mir-156 Dehydration CONCLUSIONS: Taken together, our results reveal that moderate relative miR156 transcript levels are sufficient to enhance drought resilience in alfalfa by silencing SPL13 and increasing WD40-1 expression, whereas higher miR156 overexpression results in drought susceptibility. +other 31638561 hsa-mir-9 Paranasal Sinus Neoplasms 3p seem to be important members of the sinonasal cancer pathogenesis. +other 31638561 hsa-let-7d Paranasal Sinus Neoplasms 3p (fold change: 3.07) and let-7d (fold change: 3.93) in sinonasal carcinoma patients. +transcription factor target 31638474 hsa-mir-20 Diabetes Mellitus By chromatin immunoprecipitation sequencing and chromatin immunoprecipitation quantitive polymerase chain reaction analysis of Ago2 (argonaute RISC catalytic component 2) and RNA polymerase II in response to miR-320 induction, we identified CD36 (fatty acid translocase) as a key target gene for this miRNA and showed that the induced expression of CD36 is responsible for increased fatty acid uptake, thereby causing lipotoxicity in the heart. +transcription factor target 31638474 hsa-mir-20 Hyperlipidemias By chromatin immunoprecipitation sequencing and chromatin immunoprecipitation quantitive polymerase chain reaction analysis of Ago2 (argonaute RISC catalytic component 2) and RNA polymerase II in response to miR-320 induction, we identified CD36 (fatty acid translocase) as a key target gene for this miRNA and showed that the induced expression of CD36 is responsible for increased fatty acid uptake, thereby causing lipotoxicity in the heart. +transcription factor target 31638474 hsa-mir-20 Heart Diseases By chromatin immunoprecipitation sequencing and chromatin immunoprecipitation quantitive polymerase chain reaction analysis of Ago2 (argonaute RISC catalytic component 2) and RNA polymerase II in response to miR-320 induction, we identified CD36 (fatty acid translocase) as a key target gene for this miRNA and showed that the induced expression of CD36 is responsible for increased fatty acid uptake, thereby causing lipotoxicity in the heart. +genetics_knock down_suppress 31638259 hsa-mir-425 Breast Neoplasms Knockdown of miR4255p in BC cell lines inhibited proliferation and migration. +lncRNA target 31638257 hsa-mir-489 Glioma These results indicated that miR489 may be involved in PAK5mediated regulation of glioma progression, demonstrating the potential therapeutic benefits of targeting miR489 in glioma. +other 31638237 hsa-mir-373 Breast Neoplasms KaplanMeier survival analysis revealed that six DElncRNAs (INC AC112721.1, LINC00536, MIR73HG, ADAMTS9AS1, AL356479.1 and LINC00466), nine DEmRNAs (KPNA2, RACGAP1, SHCBP1, ZNF367, NTRK2, ORS1, PTGS2, RASGRP1 and SFRP1) and two DEmiRNAs (hsamiR301b and hsamiR204) had significant effects on overall survival in BC. The present results demonstrated the aberrant expression of INC AC112721.1, AL356479.1, LINC00466 and MIR73HG in BC, indicating their potential prognostic role in patients with BC. +transcription factor target 31638233 hsa-mir-143 Aortic Aneurysm, Thoracic The results of the comparison with control group demonstrated that the increase in the expression levels of hsamiR1433p (P=0.017) and hsamiR22 (P=0.03) candidate miRNAs were statistically significant in the TAA group, but not in the TAD group. The statistically significant difference in the expression of hsamiR1433p suggests that hsamiR1433p may be a potential biomarker for TAA, as the expression of the target mRNAs KRAS and MAPK7 decreased and the miRNAmRNA association was negatively correlated. +transcription factor target 31638233 hsa-mir-143 Thoracic Aortic Dissection The results of the comparison with control group demonstrated that the increase in the expression levels of hsamiR1433p (P=0.017) and hsamiR22 (P=0.03) candidate miRNAs were statistically significant in the TAA group, but not in the TAD group. The statistically significant difference in the expression of hsamiR1433p suggests that hsamiR1433p may be a potential biomarker for TAA, as the expression of the target mRNAs KRAS and MAPK7 decreased and the miRNAmRNA association was negatively correlated. +other 31638225 hsa-mir-15b Hepatitis B, Chronic In conclusion, FAM138BhsamiR30cCCNE2/RRM2 and the SSTR5AS1hsamiR15b5pCA2 ceRNA axes may be important mechanisms for HBVrelated HCC. +other 31638225 hsa-mir-15b Carcinoma, Hepatocellular In conclusion, FAM138BhsamiR30cCCNE2/RRM2 and the SSTR5AS1hsamiR15b5pCA2 ceRNA axes may be important mechanisms for HBVrelated HCC. +other 31638225 hsa-mir-149 Hepatitis B, Chronic Univariate Cox regression analysis revealed that six RNAs (2 DELs: FAM138B, SSTR5AS1; 2 DEMs: hsamiR149, hsamiR7; 2 DEGs: CCNE2, RRM2) were significantly associated with OS; while seven RNAs (1 DEL: LINC00284; 3 DEMs: hsamiR7, hsamiR15b, hsamiR30c2; and 3 DEGs: RRM2, CCNE2, CA2) were significantly associated with RFS. +other 31638225 hsa-mir-149 Carcinoma, Hepatocellular Univariate Cox regression analysis revealed that six RNAs (2 DELs: FAM138B, SSTR5AS1; 2 DEMs: hsamiR149, hsamiR7; 2 DEGs: CCNE2, RRM2) were significantly associated with OS; while seven RNAs (1 DEL: LINC00284; 3 DEMs: hsamiR7, hsamiR15b, hsamiR30c2; and 3 DEGs: RRM2, CCNE2, CA2) were significantly associated with RFS. +other 31638225 hsa-mir-7 Carcinoma, Hepatocellular Univariate Cox regression analysis revealed that six RNAs (2 DELs: FAM138B, SSTR5AS1; 2 DEMs: hsamiR149, hsamiR7; 2 DEGs: CCNE2, RRM2) were significantly associated with OS; while seven RNAs (1 DEL: LINC00284; 3 DEMs: hsamiR7, hsamiR15b, hsamiR30c2; and 3 DEGs: RRM2, CCNE2, CA2) were significantly associated with RFS. +other 31638225 hsa-mir-7 Hepatitis B, Chronic Univariate Cox regression analysis revealed that six RNAs (2 DELs: FAM138B, SSTR5AS1; 2 DEMs: hsamiR149, hsamiR7; 2 DEGs: CCNE2, RRM2) were significantly associated with OS; while seven RNAs (1 DEL: LINC00284; 3 DEMs: hsamiR7, hsamiR15b, hsamiR30c2; and 3 DEGs: RRM2, CCNE2, CA2) were significantly associated with RFS. +genetics_overexpression_promote 31638221 hsa-mir-132 Cholangiocarcinoma The SMD of miR1323p in CCA was 0.75 (95% CI: 0.25, 1.24), which indicated that miR1323p was overexpressed in CCA tissues. +other 31638218 hsa-mir-143 Colorectal Neoplasms pcDNA3.1primiR143 and its mutant were successfully constructed and transfected into colorectal carcinoma cells. +transcription factor target 31638208 hsa-mir-138 Carcinoma, Non-Small-Cell Lung In conclusion, the present results suggested that miR1385p may be a tumor suppressor in NSCLC cells and a promising therapeutic target for treating patients with NSCLC. +lncRNA target 31638206 hsa-mir-4500 Carcinoma, Non-Small-Cell Lung Research has revealed that microRNA (miR)4500 is downregulated in nonsmall cell lung cancer (NSCLC), and miR4500 suppresses tumor growth by targeting lin28 homolog B and NRAS protooncogene, GTPase. +lncRNA target 31638205 hsa-mir-28b Carcinoma, Non-Small-Cell Lung The expression of epidermal growth factor receptor (EGFR) is regulated by microRNA (miRNA)128b in nonsmall cell lung cancer (NSCLC); however, the association between miRNA128b expression and EGFR expression has not been determined in vivo. In conclusion, the results of the present study suggested that miRNA128b may regulate the expression of EGFR in NSCLC cells, and that optimizing targeted therapy is conducive to the development of novel therapeutic strategies for the treatment of patients with lung cancer. +other 31638197 hsa-mir-222 Arthritis, Rheumatoid Previous studies indicated that miR222 was upregulated in patients with rheumatoid arthritis. +transcription factor target 31638197 hsa-mir-222 Intervertebral disc disease Therefore, miR222 may act as a potential therapeutic target for the treatment of IDD. +other 31638185 hsa-mir-146a Barrett Esophagus Then the expression of miRNAs in DCexo was explored and the role of miR146a in endothelial inflammation was investigated. +lncRNA target 31638182 hsa-mir-421 Ovarian Neoplasms Taken together, the present results demonstrated that anisomycin inhibited the activation downstream of the Notch1 pathway by attenuating the molecular sponge effect of the lncRNAMeg3/miR421/PDGFRA axis, ultimately inhibiting angiogenesis, proliferation and invasion in ovarian cancer cells. +genetics_overexpression_promote 31638178 hsa-mir-146a Pneumonia, Mycoplasma Downregulation of miR146a5p induced the protein expression of ATPbinding cassette subfamily G member 1 (ABCG1) and interleukin 1 receptorassociated kinase 1 (IRAK1), while suppressed expression was observed of the aforementioned proteins following overexpression of miR146a5p in an in vitro model of refractory Mycoplasma pneumoniae pneumonia. +lncRNA target 31638173 hsa-mir-21 Non-alcoholic Fatty Liver Disease Taken together, the results of this study demonstrate that the inhibition of miR21 expression can alleviate NAFLD by targeting LRP6 to activate the WNT/betacatenin signaling pathway. +other 31638099 hsa-mir-219 Cranial Nerve Injuries In addition, we showed that miR-219/miR-338 enhanced oligodendrocyte precursor cell differentiation and maturation in a scratch assay paradigm that re-created a nerve injury condition in vitro. Collectively, our results suggest miR-219/miR-338 as a promising treatment for axonal remyelination in the CNS following nerve injuries. +other 31638099 hsa-mir-338 Cranial Nerve Injuries In addition, we showed that miR-219/miR-338 enhanced oligodendrocyte precursor cell differentiation and maturation in a scratch assay paradigm that re-created a nerve injury condition in vitro. Collectively, our results suggest miR-219/miR-338 as a promising treatment for axonal remyelination in the CNS following nerve injuries. +lncRNA target 31637891 hsa-mir-145 Osteoarthritis CONCLUSION: An MALAT1/miR-145 axis contributes to ECM degradation in IL-1beta-induced chondrocytes through targeting ADAMTS5, suggesting that MALAT1/miR-145/ADAMTS5 signaling may underlie human OA pathogenesis. +lncRNA target 31637871 hsa-mir-26b Carcinoma, Hepatocellular Taken together, our results uncover a novel mechanistic role for miR-26b/ZNRD1 axis in HCC, proposing ZNRD1 inhibition as a potent therapeutic strategy for hepatocellular carcinoma. +transcription factor target 31637848 hsa-mir-15b Neuroblastoma These data suggest that miR-15a, miR-15b and miR-16 exert a tumor-suppressive function in NB by targeting MYCN. +transcription factor target 31637848 hsa-mir-16 Neuroblastoma These data suggest that miR-15a, miR-15b and miR-16 exert a tumor-suppressive function in NB by targeting MYCN. +lncRNA target 31637768 hsa-mir-497 Colorectal Neoplasms CONCLUSIONS: AC009022.1 enhanced CRC cell proliferation, migration, and invasion by promoting ACTR3B expression via suppressing miR +exosome 31637737 hsa-mir-208a Osteosarcoma Human osteosarcoma cells MG-63 and Saos-2 were exposed to BMSCs-derived exosomes treated with either miR-208a mimic or inhibitor. +genetics_overexpression_promote 31637717 hsa-mir-181a Pulmonary Arterial Hypertension Furthermore, the increase of intercellular cell adhesion molecule-1 (ICAM1) and vascular cell adhesion molecule-1 (VCAM1) in PAH rats was inhibited by miR-181a/b overexpression. +genetics_overexpression_promote 31637717 hsa-mir-181b Pulmonary Arterial Hypertension Furthermore, the increase of intercellular cell adhesion molecule-1 (ICAM1) and vascular cell adhesion molecule-1 (VCAM1) in PAH rats was inhibited by miR-181a/b overexpression. +lncRNA target 31637705 hsa-mir-770 Glioma Moreover, glioma cell proliferation and autophagy could be mediated through the TPT1-AS1/miR +transcription factor target 31637632 hsa-mir-129 Polycythemia Vera Our results demonstrate that lnc-RP5 promotes the expression of PFV Tas through the miR +lncRNA target 31637455 hsa-mir-211 Uterine Cervical Neoplasms While the miR-211 inhibitor exerted reverse effects on C-33A cervical cancer cells. +lncRNA target 31637209 hsa-mir-372 Stomach Neoplasms The ADAMTS9-AS2/miR-372/CADM2 could act as a promising target for GC treatment. +genetics_overexpression_promote 31637133 hsa-mir-383 Stomach Neoplasms Besides, overexpression of miR +lncRNA target 31637007 hsa-mir-124 Postoperative Complications Our study indicates that miR-124/VAMP3 is involved in surgery-induced microglial activation and that targeting miR-124/VAMP3 could be a potential therapeutic strategy for postoperative disorders involving microglial activation. +lncRNA target 31636893 hsa-mir-342 Endometriosis CONCLUSION: LncRNA H19 was down-regulated in PFMC of patients with EMS or under Th17 polarizing conditions, and LncRNA H19 over-expression suppressed Th17 cell differentiation and ESCs proliferation through miR +circulation_biomarker_diagnosis_up 31636734 hsa-mir-222 Thyroid Nodule These findings indicated that the altered circulating miRNAs may discriminate PTC and benign thyroid nodules from controls, and serum miR +circulation_biomarker_diagnosis_up 31636734 hsa-mir-17 Parathyroid Neoplasms These findings indicated that the altered circulating miRNAs may discriminate PTC and benign thyroid nodules from controls, and serum miR +circulation_biomarker_diagnosis_up 31636734 hsa-mir-17 Thyroid Nodule These findings indicated that the altered circulating miRNAs may discriminate PTC and benign thyroid nodules from controls, and serum miR +circulation_biomarker_diagnosis_up 31636734 hsa-mir-222 Parathyroid Neoplasms These findings indicated that the altered circulating miRNAs may discriminate PTC and benign thyroid nodules from controls, and serum miR +other 31636666 hsa-mir-199a Leukemia, Myeloid, Acute These results revealed that the miR-199a-5p/DRAM1/autophagy signaling represented a novel pathway regulating chemoresistance, indicating a potential therapeutic strategy for the intervention in drug-resistant AML. +other 31636472 hsa-mir-490 Carcinoma, Hepatocellular 3p/HDAC2 axis in HCC. +exosome 31636323 hsa-mir-1 Lung Neoplasms This results opens the avenue to the use of EV-associated miRNA of pleural fluids and lavages as an untapped source of biomarkers, and specifically, identifies miRNA +exosome 31636323 hsa-mir-144 Lung Neoplasms This results opens the avenue to the use of EV-associated miRNA of pleural fluids and lavages as an untapped source of biomarkers, and specifically, identifies miRNA +exosome 31636323 hsa-mir-150 Lung Neoplasms This results opens the avenue to the use of EV-associated miRNA of pleural fluids and lavages as an untapped source of biomarkers, and specifically, identifies miRNA +circulation_biomarker_diagnosis_up 31636041 hsa-mir-411 Ischemia The ISO-miR-411/WT-miR-411 ratio is downregulated under acute ischemia, both in cells and a murine ischemia model, but is upregulated instead in chronically ischemic human blood vessels. +circulation_biomarker_diagnosis_up 31636041 hsa-mir-411 Chronic Disease The ISO-miR-411/WT-miR-411 ratio is downregulated under acute ischemia, both in cells and a murine ischemia model, but is upregulated instead in chronically ischemic human blood vessels. +circRNA target 31636010 hsa-mir-20b Diabetic Retinopathy Changes in expression of circDNMT3B and miR-20b-5p were confirmed in the proliferative fibrovascular membranes of patients with diabetic retinopathy. INTERPRETATION: Downregulation of circDNMT3B contributes to vascular dysfunction in diabetic retinas through regulating miR-20b-5p and BAMBI, providing a potential treatment strategy for diabetic retinopathy. +other 31635993 hsa-mir-200c Carcinoma, Renal Cell These results suggest that miR-141, miR-200b, and miR-200c are independent prognostic markers for ccRCC. +other 31635993 hsa-mir-141 Carcinoma, Renal Cell These results suggest that miR-141, miR-200b, and miR-200c are independent prognostic markers for ccRCC. +other 31635993 hsa-mir-200b Carcinoma, Renal Cell These results suggest that miR-141, miR-200b, and miR-200c are independent prognostic markers for ccRCC. +genetics_overexpression_promote 31635836 hsa-mir-382 Breast Neoplasms Overexpression of miRNA +lncRNA target 31635804 hsa-mir-372 Carcinoma, Hepatocellular 3p-induced tumor suppressive effects on HCC cells. +other 31635802 hsa-mir-7 Breast Neoplasms 5p-SOX2 regulatory pathway might provide a new and effective therapeutic strategy to prevent breast cancer development. +transcription factor target 31635801 hsa-mir-128 Inflammation 3p targets sirtuin 1 to mediate the TNF-alpha-induced inflammatory response in BMSCs, which may provide new strategies to protect against inflammatory-dependent impairments in BMSCs. +circulation_biomarker_diagnosis_ns 31634961 hsa-mir-20 Obesity MATERIALS AND METHODS: The adipose tissue expression levels of miR-320 and ERs markers (GRP78, GRP94, Derlin-1 and CHOP) and the serum concentration of inflammatory cytokines (TNF-alpha, NF-kappaB and IL-6) in obese patients were evaluated using quantitative real-time RT-PCR or enzyme-linked immunosorbent assay. +other 31634961 hsa-mir-20 Inflammation The correlation of miR-320 with genes involved in ERs and inflammation was analyzed. The effects of miR-320 on ERs and inflammation were explored using mature 3T3-L1 adipocytes, which were pretreated with palmitic acid (PA). +genetics_knock down_promote 31634561 hsa-mir-214 Uterine Cervical Neoplasms Compared to normal tissues, a down-regulated level of miR-214 was observed in cervical cancer, while MKK3 was up-regulated. Next, we demonstrated that over-expression of miR-214 or knockdown of MKK3 can inhibit the growth, proliferation, invasion and migration of cervical cancer in vitro and in vivo. +lncRNA target 31633295 hsa-mir-205 Venous Thrombosis These results elucidated the pro-angiogenesis effects of miR-205 in EPCs and established it as a potential target for DVT treatment. +other 31633290 hsa-mir-205 Macular Degeneration 5p in wet AMD patients as compared with controls. +other 31633290 hsa-mir-145 Macular Degeneration 5p in wet AMD patients as compared with controls. +other 31633290 hsa-mir-126 Macular Degeneration 5p in wet AMD patients as compared with controls. +other 31633290 hsa-mir-34 Macular Degeneration 5p in wet AMD patients as compared with controls. +genetics_overexpression_suppress 31633240 hsa-mir-1296 Osteosarcoma 5p overexpression remarkably repressed OS cell proliferation, migration, and invasion. +genetics_knock down_promote 31633236 hsa-mir-486 Carcinoma, Hepatocellular 5p was significantly increased In HCC after DLGAP1-AS1 knockdown. +other 31633225 hsa-mir-19a Myocardial Infarction The expression of miR-19a in the infarct zone of AMI rats and myocardial tissue in the same position in sham rats was analyzed using RT-qPCR while Na((+)) /H((+)) exchanger 1 (NHE-1) was detected by Western blotting. Decreased miR-19a expression, as well as increased apoptosis and NHE-1 expression, were observed in the AMI model. +other 31633225 hsa-mir-19a Coronary Disease miR-19a has been shown to be involved in coronary microvascular obstruction injury; however, the underlying molecular mechanisms remain unknown. +genetics_overexpression_suppress 31633225 hsa-mir-19a Hypoxia We also observed the effects of overexpressing miR-19a or administering an NHE-1 inhibitor (cariporide) on hypoxia-induced (HI) calcium overload and apoptosis in primary cardiomyocytes. +other 31632984 hsa-mir-92a Carcinoma, Non-Small-Cell Lung Expression level of miR-92a was detected by the TCGA database and was confirmed by non-small-cell lung cancer (NSCLC) tissues. Expression of miR-92a was identified to be upregulated in NSCLC, especially in lung squamous cell carcinoma (LUSC). +other 31632984 hsa-mir-92a Syphilis Expression of miR-92a was identified to be upregulated in NSCLC, especially in lung squamous cell carcinoma (LUSC). +other 31632908 hsa-mir-146a Multiple Pulmonary Nodules A prediction model was established by combining 3 miRNAs (miRNA-146a, -200b, and -7) and CT features to identify the pulmonary nodules of these patients. +circulation_biomarker_diagnosis_ns 31632908 hsa-mir-200b Multiple Pulmonary Nodules Conclusion: Plasma miRNA-146a, miRNA-200b, and miRNA-7 may be potential biomarkers for the early diagnosis of lung cancer. +exosome 31632591 hsa-mir-590 Intrahepatic Cholestasis of Pregnancy 3p in urinary exosomes reduced the expression of ICAM1, which in turn increased the incidence of ICP. +exosome 31632591 hsa-mir-29a Intrahepatic Cholestasis of Pregnancy 3p in urinary exosomes reduced the expression of ICAM1, which in turn increased the incidence of ICP. +exosome 31632591 hsa-mir-21 Intrahepatic Cholestasis of Pregnancy 3p in urinary exosomes reduced the expression of ICAM1, which in turn increased the incidence of ICP. +other 31632586 hsa-mir-30 Cholangiocarcinoma 5p expression was negative correlated with PCAT6 expression in intrahepatic cholangiocarcinoma. +lncRNA target 31632583 hsa-mir-135a Reperfusion Injury The present study aims to investigate whether lncRNA ROR can promote the cerebral hypoxia/reoxygenation (H/R) injury in vitro, a cellular model of cerebral ischemia/reperfusion injury, through inhibiting the expression of miR-135a-5p or upregulating the expression of ROCK1 and ROCK2. +genetics_GWAS 31632582 hsa-mir-221 Essential Hypertension Therefore, rs2858060 in miR-221 could play an important role as a genetic risk factor for the development of essential hypertension in the Chinese population. +transcription factor target 31632566 hsa-mir-27b Colorectal Neoplasms Thus, we presume that miR-27b may be a therapeutic anti-tumor agent for CRC via targeting PI3K p110alpha. +lncRNA target 31632562 hsa-mir-193a Inflammation Therefore, NEAT1 may function as a ceRNA by sponging miR-193a-3p to regulate the activation of TLR4/NF-kappaB signaling to alleviate inflammation and apoptosis of WI-38 cells induced by LPS, thus influencing the development of pneumonia. +other 31632559 hsa-mir-1277 Pneumonia, Mycoplasma The results showed that CRNDE expression was significantly downregulated, whereas miR-1277 expression was significantly upregulated in PE placental tissues. +genetics_knock down_promote 31632558 hsa-mir-4673 Carcinoma, Hepatocellular In addition, we showed overexpression of miR-4673 or knockdown of SOCS1 could partially reverse the effects of SNHG14 overexpression on HCC cells. +genetics_GWAS 31632547 hsa-mir-181b Gallbladder Neoplasms Based on Catalogue of Somatic Mutations in Cancer (COSMIC) database (408 GBC samples), there was negative correlation between hsa-miR-181b-5p/-3p and CREBRF which was a direct targeting of miR-181b. +transcription factor target 31632533 hsa-mir-21 Acute Kidney Injury AR/miR-21 axis could be a potential therapeutic target for the kidney ischemia injury. +other 31632533 hsa-mir-21 Anodontia dependent apoptosis. +transcription factor target 31632526 hsa-mir-514a Pulmonary Embolism These results suggest that MiR-514a-5p helps to exasperate PTE development by promoting several aspects of PTE pathology, including inflammation, lung injury, and right ventricular hypertrophy by targeting CHRDL1. +genetics_overexpression_promote 31632522 hsa-mir-185 Thyroid Cancer, Papillary 5p as miRNA sponge and overexpression of FOXD2-AS1 partially reversed the suppressive effect of miR +lncRNA target 31632521 hsa-mir-142 Cholangiocarcinoma Mechanistically, we demonstrated that NNT-AS1 might function as a ceRNA in regulating HMGA2 (high mobility group AT-hook 2) through competitively binding to miR +lncRNA target 31632519 hsa-mir-421 Uterine Cervical Neoplasms The results suggested that lidocaine inhibited the growth of cervical cancer cells by modulating the lncRNA-MEG3/miR-421/BTG1 signaling pathway, providing opportunities for treating cervical cancer. +genetics_overexpression_promote 31632515 hsa-mir-708 Colorectal Neoplasms Further studies showed that the overexpression of miR-708 and silence of ZEB1 inhibited stage of CRC via inhibiting AKT/mTOR signaling pathway in CRC cells. +genetics_overexpression_promote 31632488 hsa-mir-922 Thyroid Cancer, Papillary Moreover, ENST00000489676 may mediate tumor suppression in PTC cells through suppressing miR-922. The overexpression of ENST00000489676 inhibited the progression of PTC through suppressing miR-922. +lncRNA target 31632480 hsa-mir-196b Carcinoma, Hepatocellular Subsequently, in order to obtain the potential target genes of miR-196b-5p, we overlapped the predicted target genes and down-regulated mRNAs in HCC based on TCGA database. +lncRNA target 31632145 hsa-mir-22 Nasopharyngeal Carcinoma Through the subgroup analysis for OS and DFS/PFS/RFS, we found that elevated expression of miR-22 significantly correlated with good prognosis in most subgroups, while it predicted a worse prognosis in nasopharyngeal carcinoma subgroup. +lncRNA target 31632084 hsa-mir-942 Carcinoma, Hepatocellular CONCLUSION: miR-942 may serve as a potential biomarker for HCC and its inhibitor may be a therapeutic agent for the treatment of this deadly disease. +genetics_overexpression_promote 31632082 hsa-mir-200a Ovarian Neoplasms Overexpression of miR-200a-3p markedly promoted the proliferation, colony formation and invasion of ovarian cancer cells. +other 31632081 hsa-mir-218 Breast Neoplasms 5p-Cx43 axis was versatile and indicated significant potency in breast cancer cells. +genetics_overexpression_promote 31632079 hsa-mir-183 Colorectal Neoplasms 5p overexpression resulted in opposite effects. +lncRNA target 31632071 hsa-mir-214 Pancreatic Carcinoma CONCLUSION: Our results revealed that lncRNA HCP5 is highly expressed in HCC, and development of GEM-resistance PC cells involving the processes of proliferation, invasive, migration, cell apoptosis and autophagy through the miR3p/HDGF axis. +genetics_overexpression_suppress 31632070 hsa-mir-483 Stomach Neoplasms 3p inhibited proliferative and migratory capacities of GC cells, which were reversed by CDK6 overexpression. +genetics_knock down_suppress 31632061 hsa-mir-155 Carcinoma, Endometrioid And knockdown of miR-155 could inhibit the mobility of endometrial carcinoma cells. CONCLUSION: Our study suggested that RBPJ can inhibit the movability of endometrial carcinoma cells by miR-155/NF-kappaB/ROS pathway. +genetics_overexpression_promote 31632058 hsa-mir-421 Gallbladder Neoplasms MiR-421 overexpression led to increased migration and invasion rates of GBC. +circulation_biomarker_prognosis_ns 31632022 hsa-mir-425 Carcinoma, Non-Small-Cell Lung METHODS: Circulating exosomal miR +lncRNA target 31632001 hsa-mir-664a Pulmonary Disease, Chronic Obstructive CONCLUSION: The present study validated significant upregulation of hsa-miR-664a-3p in COPD patients, and its target gene FHL1 was downregulated and positively correlated with FEV1/FVC%; both hsa-miR-664a-3p and FHL1 could be regulated by cigarette smoke extract. +circulation_biomarker_diagnosis_up 31631818 hsa-mir-125b Asthma CONCLUSION: The expression levels of miRNA-125b in serum exosomes had a high diagnostic efficacy and might serve as a noninvasive diagnostic marker for asthma severity. +exosome 31631786 hsa-mir-4461 Colorectal Neoplasms This study aims to investigate the function of BMSCs-derived exosome miR-4461 in CRC. +lncRNA target 31631598 hsa-mir-148b Maternal Cholestasis OBJECTIVE: To investigate the expression of miRNA-148b-3p and its target gene in the placenta between normal pregnant women and pregnant women with intrahepatic cholestasis of pregnancy (ICP) and to explore the possible mechanism of glucose metabolism of offspring with maternal cholestasis. CONCLUSION: miR-148b-3p might participate in glucose metabolism of offspring with maternal cholestasis through the negative regulation of GLUT1 expression in placental trophoblast cells. +other 31631531 hsa-mir-15a Hypoxia-Ischemia, Brain This research intended to probe the regulatory function and the mechanism of miR-15a on the ischemic brain injury induced by oxygen-glucose deprivation/reoxygenation (OGD/R) in neurons of rats. +lncRNA target 31631531 hsa-mir-15a Osteochondritis Dissecans After transfection with miR-15a mimic negative control (NC), miR-15a mimic, miR-15a inhibitor NC and miR-15a inhibitor, the OGD/R-induced apoptosis were detected. +circulation_biomarker_diagnosis_up 31631067 hsa-mir-888 Lymphoma, Large B-Cell, Diffuse Cytoplasmic circ-APC functioned as a sponge for miR-888, thus post-transcriptionally upregulating APC by alleviating the repressive effects of miR-888 on this gene. +other 31631065 hsa-mir-221 Diabetic Nephropathies Thus, lncRNA GAS5 was involved in the progression of DN by sponging miR-221 and contributed to lncRNA-directed diagnostics and therapeutics in DN. +lncRNA target 31631038 hsa-mir-637 Colorectal Neoplasms INTERPRETATION: circHIPK3 functions as a chemoresistant gene in CRC cells by targeting the miR-637/STAT3/Bcl-2/beclin1 axis and might be a prognostic predictor for CRC patients who receive oxaliplatin-based chemotherapy. +other 31630797 hsa-mir-664a Osteoporosis Thus, the newly identified miR-664a-5p-HMGA2 pathway expands our understanding of the mechanisms underlying the osteogenic differentiation of human BMSCs, may provide deeper insights into the regulation of this differentiation, and can point to new effective methods for treating osteoporosis. +lncRNA target 31630796 hsa-mir-520h Diabetic Nephropathies The regulatory loop NORAD/miR-520h/TLR4 promotes the proliferative ability and inhibits apoptosis in glomerular mesangial cells, thus aggravating the progression of DN. +other 31630447 hsa-mir-146a psoriasis 1 Our data together suggest that SERPINB2 and miR-146a/b are part of disease-related network of molecules that are coordinately regulated and act in controlling the inflammatory responses in psoriatic skin. +other 31630447 hsa-mir-146b psoriasis 1 Our data together suggest that SERPINB2 and miR-146a/b are part of disease-related network of molecules that are coordinately regulated and act in controlling the inflammatory responses in psoriatic skin. +tissue_expression_ns 31630337 hsa-mir-29b Kidney Cortex Necrosis METHODS: We evaluated miR-29b expression in 35 HSPN renal tissues based on crescent formation, glomerular sclerosis, interstitial fibrosis, thrombosis formation and capillary loop necrosis. +tissue_expression_ns 31630337 hsa-mir-29b-1 hereditary sensory neuropathy type 4 METHODS: We evaluated miR-29b expression in 35 HSPN renal tissues based on crescent formation, glomerular sclerosis, interstitial fibrosis, thrombosis formation and capillary loop necrosis. +tissue_expression_ns 31630337 hsa-mir-29b Fibrosis METHODS: We evaluated miR-29b expression in 35 HSPN renal tissues based on crescent formation, glomerular sclerosis, interstitial fibrosis, thrombosis formation and capillary loop necrosis. +tissue_expression_ns 31630337 hsa-mir-29b Thrombosis METHODS: We evaluated miR-29b expression in 35 HSPN renal tissues based on crescent formation, glomerular sclerosis, interstitial fibrosis, thrombosis formation and capillary loop necrosis. +tissue_expression_ns 31630337 hsa-mir-29b-1 Kidney Cortex Necrosis METHODS: We evaluated miR-29b expression in 35 HSPN renal tissues based on crescent formation, glomerular sclerosis, interstitial fibrosis, thrombosis formation and capillary loop necrosis. +tissue_expression_ns 31630337 hsa-mir-29b hereditary sensory neuropathy type 4 METHODS: We evaluated miR-29b expression in 35 HSPN renal tissues based on crescent formation, glomerular sclerosis, interstitial fibrosis, thrombosis formation and capillary loop necrosis. +other 31630337 hsa-mir-29b Purpura The present study aimed to elucidate the role of miR-29b in Henoch Schonlein purpura nephritis (HSPN) and its underlying molecular mechanism in angiotensin II (Ang II)-induced human glomerular mesangial cell (HGMC) activation. +tissue_expression_ns 31630337 hsa-mir-29b-1 Nephrosclerosis METHODS: We evaluated miR-29b expression in 35 HSPN renal tissues based on crescent formation, glomerular sclerosis, interstitial fibrosis, thrombosis formation and capillary loop necrosis. +tissue_expression_ns 31630337 hsa-mir-29b-1 Thrombosis METHODS: We evaluated miR-29b expression in 35 HSPN renal tissues based on crescent formation, glomerular sclerosis, interstitial fibrosis, thrombosis formation and capillary loop necrosis. +other 31630337 hsa-mir-29b-1 Purpura The present study aimed to elucidate the role of miR-29b in Henoch Schonlein purpura nephritis (HSPN) and its underlying molecular mechanism in angiotensin II (Ang II)-induced human glomerular mesangial cell (HGMC) activation. +tissue_expression_ns 31630337 hsa-mir-29b Nephrosclerosis METHODS: We evaluated miR-29b expression in 35 HSPN renal tissues based on crescent formation, glomerular sclerosis, interstitial fibrosis, thrombosis formation and capillary loop necrosis. +tissue_expression_ns 31630337 hsa-mir-29b-1 Fibrosis METHODS: We evaluated miR-29b expression in 35 HSPN renal tissues based on crescent formation, glomerular sclerosis, interstitial fibrosis, thrombosis formation and capillary loop necrosis. +circulation_biomarker_diagnosis_ns 31630081 hsa-mir-122 Poikiloderma with Neutropenia In contrast, PNGR and IPGR displayed insufficient glucose, insulin and leptin amidst high ketones with a dichotomy in circulating miR-122 of PNGR C polymorphism and the presence of miR-149 C, and miR-499 G alleles are a genetic determinant for the risk of idiopathic RPL. +genetics_GWAS 31605260 hsa-mir-146a Abortion, Habitual The aim of this study was to investigate the possible association between miR-146a C > G, miR-149 T > C, miR-196a2 T > C, and miR-499 A > G polymorphisms and genetic susceptibility to recurrent pregnancy loss (RPL). +genetics_GWAS 31605260 hsa-mir-499 Abortion, Habitual CONCLUSION: This study suggests that miR-149 T > C polymorphism and the presence of miR-149 C, and miR-499 G alleles are a genetic determinant for the risk of idiopathic RPL. +genetics_GWAS 31605260 hsa-mir-196a-2 Abortion, Habitual The aim of this study was to investigate the possible association between miR-146a C > G, miR-149 T > C, miR-196a2 T > C, and miR-499 A > G polymorphisms and genetic susceptibility to recurrent pregnancy loss (RPL). +lncRNA target 31605132 hsa-mir-183 Uterine Cervical Neoplasms Additionally, miR-183 mimic could inverse the antitumor function of CRNDE inhibition and partially eliminated the attenuated expression of CCNB1 induced by silencing CRNDE, indicating that CRNDE could positively regulate CCNB1 expression by sponging miR-183. +other 31604679 hsa-mir-5188 Breast Neoplasms This study identifies miR-5188 as a novel oncomiR and provides a new theoretical basis for the clinical use of miR-5188 antagonists in the treatment of breast cancer. +transcription factor target 31604677 hsa-mir-34a Atherosclerosis Our studies outline a central role of miR-34a in regulating macrophage cholesterol efflux, inflammation, and atherosclerosis, suggesting that miR-34a is a promising target for treatment of cardiometabolic diseases. +circulation_biomarker_diagnosis_ns 31604377 hsa-mir-181a Sepsis Aggregately 136 sepsis patients and 151 healthy people were recruited, and their fasting peripheral blood was gathered to detect expressions of CRNDE and miR-181a-5p. +circulation_biomarker_diagnosis_ns 31603918 hsa-mir-4428 Breast Neoplasms We conclude that serum miR-4428 and miR-4480 may be useful as biomarkers for predicting brain metastasis in patients with breast cancer. +circulation_biomarker_diagnosis_ns 31603918 hsa-mir-4480 Breast Neoplasms We conclude that serum miR-4428 and miR-4480 may be useful as biomarkers for predicting brain metastasis in patients with breast cancer. +other 31603566 hsa-mir-590 Hearing Loss, Sudden 3p, and -30a-3p were identified as significantly differentially expressed in SSNHL patients. +other 31603261 hsa-mir-424 Ovarian Neoplasms RES apoptotic effect and enhancement of OC cells to chemotherapy were associated with decreased abundance of GAL-3, a common cell survival molecule that promotes tumorigenesis and increased transcription of miR3p that has the ability to degrade cellular GAL-3. +other 31603116 hsa-mir-155 Breast Neoplasms CONCLUSION: Our data showed that miR-21 and miR-155 oncomiRs can be considered as noninvasive biomarkers for monitoring breast carcinomas. +other 31603116 hsa-mir-21 Breast Neoplasms CONCLUSION: Our data showed that miR-21 and miR-155 oncomiRs can be considered as noninvasive biomarkers for monitoring breast carcinomas. +lncRNA target 31602666 hsa-mir-183 Neuralgia Overall, our study pointed out that miR-183 was a part of the negative regulator which could relieve neuropathic pain by targeting MAP3K4. +lncRNA target 31602322 hsa-mir-625 Inflammatory Bowel Diseases In addition, we validated the most significantly up/down-expressed miRNAs (miR-92b, miR-625) and two of their corresponding target mRNAs (AQP8 and TAGAP, CCL11 and CHI3L1) in colon tissues of UC models preliminarily. +lncRNA target 31602322 hsa-mir-92b Inflammatory Bowel Diseases In addition, we validated the most significantly up/down-expressed miRNAs (miR-92b, miR-625) and two of their corresponding target mRNAs (AQP8 and TAGAP, CCL11 and CHI3L1) in colon tissues of UC models preliminarily. +genetics_knock down_promote 31602267 hsa-mir-548k Esophageal Squamous Cell Carcinoma Targeting the NF90/miR-548k/lncRNA-LET feedback loop via simultaneously depleting NF90 and miR-548k and simultaneously overexpressing lncRNA-LET significantly inhibits ESCC cell proliferation and migration in vitro and ESCC tumor growth in vivo. +circulation_biomarker_diagnosis_up 31602261 hsa-mir-21 Lung Neoplasms Results: We identified that the expressions of 10 plasma miRNAs (miR-21, miR-20a, miR-210, miR-145, miR-126, miR-223, miR-197, miR-30a, miR-30d, miR-25), smoking status, fever, cough, chest pain or tightness, bloody phlegm, haemoptysis, were significantly different between lung cancer and control groups (P<0.05). +circulation_biomarker_diagnosis_up 31602261 hsa-mir-145 Lung Neoplasms Results: We identified that the expressions of 10 plasma miRNAs (miR-21, miR-20a, miR-210, miR-145, miR-126, miR-223, miR-197, miR-30a, miR-30d, miR-25), smoking status, fever, cough, chest pain or tightness, bloody phlegm, haemoptysis, were significantly different between lung cancer and control groups (P<0.05). +circulation_biomarker_diagnosis_up 31602261 hsa-mir-210 Lung Neoplasms Results: We identified that the expressions of 10 plasma miRNAs (miR-21, miR-20a, miR-210, miR-145, miR-126, miR-223, miR-197, miR-30a, miR-30d, miR-25), smoking status, fever, cough, chest pain or tightness, bloody phlegm, haemoptysis, were significantly different between lung cancer and control groups (P<0.05). +circulation_biomarker_diagnosis_up 31602261 hsa-mir-223 Lung Neoplasms Results: We identified that the expressions of 10 plasma miRNAs (miR-21, miR-20a, miR-210, miR-145, miR-126, miR-223, miR-197, miR-30a, miR-30d, miR-25), smoking status, fever, cough, chest pain or tightness, bloody phlegm, haemoptysis, were significantly different between lung cancer and control groups (P<0.05). +circulation_biomarker_diagnosis_up 31602261 hsa-mir-25 Lung Neoplasms Results: We identified that the expressions of 10 plasma miRNAs (miR-21, miR-20a, miR-210, miR-145, miR-126, miR-223, miR-197, miR-30a, miR-30d, miR-25), smoking status, fever, cough, chest pain or tightness, bloody phlegm, haemoptysis, were significantly different between lung cancer and control groups (P<0.05). +circulation_biomarker_diagnosis_up 31602261 hsa-mir-197 Lung Neoplasms Results: We identified that the expressions of 10 plasma miRNAs (miR-21, miR-20a, miR-210, miR-145, miR-126, miR-223, miR-197, miR-30a, miR-30d, miR-25), smoking status, fever, cough, chest pain or tightness, bloody phlegm, haemoptysis, were significantly different between lung cancer and control groups (P<0.05). +circulation_biomarker_diagnosis_up 31602261 hsa-mir-20a Lung Neoplasms Results: We identified that the expressions of 10 plasma miRNAs (miR-21, miR-20a, miR-210, miR-145, miR-126, miR-223, miR-197, miR-30a, miR-30d, miR-25), smoking status, fever, cough, chest pain or tightness, bloody phlegm, haemoptysis, were significantly different between lung cancer and control groups (P<0.05). +transcription factor target 31602243 hsa-mir-877 Uterine Cervical Neoplasms In conclusion, miR-877 may play an antitumor role in cervical cancer by directly targeting MACC1, which suggests that this miRNA may be a promising therapeutic target for the treatment of patients with such an aggressive gynecological cancer. +lncRNA target 31602239 hsa-mir-10b Esophageal Neoplasms Compared with miR-10b inhibitor group and control group, miR-10b mimic promoted esophageal cancer cell cycle progression, inhibited apoptosis of esophageal cancer cells and promoted the migration and invasion of cells. +lncRNA target 31602231 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck 5p-targeting PDCD4 suppresses apoptosis in human TSCC cell lines. +transcription factor target 31602229 hsa-mir-205 Breast Neoplasms 5p may inhibit gemcitabine resistance in breast cancer cells via inhibition of ERp29 expression. +genetics_knock down_promote 31602223 hsa-mir-133a Urinary Bladder Neoplasms Furthermore, loss- and gain-of-function experiments indicated that miR-133a acted as a downstream effector in XIST-mediated bladder cancer cell proliferation and migration. +other 31602220 hsa-mir-145 Cicatrix, Hypertrophic The present study demonstrated that miR-145 expression is reduced in hypertrophic scar tissues and negatively associated with SOX-9 expression. +genetics_overexpression_promote 31602205 hsa-mir-138 Myocardial Reperfusion Injury Overexpression of miR-138 reduced myocardial I/R injury-induced infarct sizes and myocardial enzyme levels, and it also inhibited the expression of proteins related to mitochondrial morphology and myocardial I/R-induced mitochondrial apoptosis by targeting HIF1-alpha. +transcription factor target 31602202 hsa-mir-204 Hypoxia-Ischemia, Brain Taken together, the results of the present study demonstrated that miR-204 was downregulated in HIE and that miR-204 may serve important roles in the pathogenesis of HIE through targeting KLLN. +circulation_biomarker_prognosis_ns 31602161 hsa-mir-21 Esophageal Squamous Cell Carcinoma The area under the ROC curve (AUC) of plasma miR-21 for diagnosing T stage, N stage, M stage, and pathological differentiation of ESCC was 0.819, 0.758, 0.824, and 0.725, respectively, and that of plasma miR-93 for diagnosing T stage, N stage, and M stage of ESCC was 0.827, 0.815, and 0.814, respectively. +circulation_biomarker_prognosis_ns 31602161 hsa-mir-93 Esophageal Squamous Cell Carcinoma The area under the ROC curve (AUC) of plasma miR-21 for diagnosing T stage, N stage, M stage, and pathological differentiation of ESCC was 0.819, 0.758, 0.824, and 0.725, respectively, and that of plasma miR-93 for diagnosing T stage, N stage, and M stage of ESCC was 0.827, 0.815, and 0.814, respectively. +lncRNA target 31601878 hsa-mir-125b Colitis Also, P35K EVs modulated innate immunity, while P100K EVs decreased inflammation through the downregulation of colitis-associated microRNAs, especially miR-125b, associated with a higher expression of the NFkappaB inhibitor TNFAIP3 (A20). +other 31601781 hsa-mir-200c Breast Neoplasms Radiotherapy is essential to treat breast cancer and microRNA (miRNA) miR-200c is considered as a radiosensitizer of breast cancer. In the present study, we showed that induction of miR-200c led to widespread alteration in long noncoding RNA (lncRNA) expression in breast cancer cells. +other 31601255 hsa-mir-203 Ovarian Neoplasms Therefore, AB209371 may down-regulate miR-203 to up-regulate Survivin, thereby promoting OC cell proliferation. +lncRNA target 31601173 hsa-mir-767 Multiple Myeloma CONCLUSIONS: Circ-SMARCA5 is downregulated and correlated with lower beta2-MG level and ISS stage as well as better prognosis in MM patients, and it inhibits proliferation but promotes apoptosis of MM cells via directly sponging miR +genetics_overexpression_promote 31601147 hsa-mir-342 Osteosarcoma 5p overexpression remarkably suppressed the viability and invasion while enhanced the apoptosis of OS cells; meanwhile, Wnt7b, beta-catenin, c-myc, and cyclin D1 proteins were reduced while E-cadherin protein showed to be increased. +other 31601141 hsa-mir-98 Reperfusion Injury Treatment with miR-98 improved significantly the locomotor impairment. +other 31601141 hsa-mir-98 limb ischemia Treatment with miR-98 improved significantly the locomotor impairment. +lncRNA target 31601093 hsa-mir-34a Myocardial Ischemia Hence, miR-34a-5p might be a potential target for treatment of myocardial ischemia-reperfusion injury. +transcription factor target 31601077 hsa-mir-361 Cognition Disorders 3p inhibited beta-amyloid accumulation by targeting BACE1, which thus weakened cognitive deficits in Alzheimer's disease. +transcription factor target 31601077 hsa-mir-361 Alzheimer Disease 3p inhibited beta-amyloid accumulation by targeting BACE1, which thus weakened cognitive deficits in Alzheimer's disease. +circulation_biomarker_diagnosis_ns 31601014 hsa-mir-122 Critical Illness METHODS AND RESULTS: We recently described alterations in serum levels of 7 miRNAs (miR-122, miR-133a, miR-143, miR-150, miR-155, miR-192, and miR-223) in critically ill patients at a medical ICU. +circulation_biomarker_diagnosis_ns 31601014 hsa-mir-150 Critical Illness METHODS AND RESULTS: We recently described alterations in serum levels of 7 miRNAs (miR-122, miR-133a, miR-143, miR-150, miR-155, miR-192, and miR-223) in critically ill patients at a medical ICU. +circulation_biomarker_diagnosis_ns 31601014 hsa-mir-192 Critical Illness METHODS AND RESULTS: We recently described alterations in serum levels of 7 miRNAs (miR-122, miR-133a, miR-143, miR-150, miR-155, miR-192, and miR-223) in critically ill patients at a medical ICU. +circulation_biomarker_diagnosis_ns 31601014 hsa-mir-143 Critical Illness METHODS AND RESULTS: We recently described alterations in serum levels of 7 miRNAs (miR-122, miR-133a, miR-143, miR-150, miR-155, miR-192, and miR-223) in critically ill patients at a medical ICU. +circulation_biomarker_diagnosis_ns 31601014 hsa-mir-155 Critical Illness METHODS AND RESULTS: We recently described alterations in serum levels of 7 miRNAs (miR-122, miR-133a, miR-143, miR-150, miR-155, miR-192, and miR-223) in critically ill patients at a medical ICU. +circulation_biomarker_diagnosis_ns 31601014 hsa-mir-133a Critical Illness METHODS AND RESULTS: We recently described alterations in serum levels of 7 miRNAs (miR-122, miR-133a, miR-143, miR-150, miR-155, miR-192, and miR-223) in critically ill patients at a medical ICU. +circulation_biomarker_diagnosis_ns 31601014 hsa-mir-223 Critical Illness METHODS AND RESULTS: We recently described alterations in serum levels of 7 miRNAs (miR-122, miR-133a, miR-143, miR-150, miR-155, miR-192, and miR-223) in critically ill patients at a medical ICU. +genetics_overexpression_promote 31600451 hsa-mir-1298 Urinary Bladder Neoplasms Further, we observed that the promotion of BC cell proliferation, migration, and invasiveness from Cx43 on could be partially attenuated by overexpressing miR-1298. +other 31600281 hsa-mir-150 Heart Failure 5p is an independent predictor of overt heart failure and thus may be used in the risk assessment of these patients. +lncRNA target 31600142 hsa-mir-134 Osteosarcoma CONCLUSION: In osteosarcoma, lncRNA TTN-AS1 promoted the expression of MBTD1 by targeting miR +genetics_knock down_promote 31599823 hsa-mir-145 Glioma CONCLUSION: Knockdown of circular RNA CEP128 suppresses cell proliferation and improves the cytotoxic efficacy of temozolomide in glioma cells by regulating miR +lncRNA target 31599709 hsa-mir-181a Squamous Cell Carcinoma of Head and Neck Moreover, sh-CCAT1 inhibited OSCC tissues growth through inhibiting Wnt signaling in a miR-181a-dependent manner in vivo. +other 31599663 hsa-mir-326 Behcet Syndrome Conclusion: MiR-326 expression rate can be used as a biomarker for prediction of uveitis and severe eye involvement in patients with BD. +other 31599491 hsa-mir-200 Glioma LINC00115 also promotes ZNF596 transcription by preventing binding of miR-200s to the 5'-UTR of ZNF596, resulting in augmented ZNF596/EZH2/STAT3 signaling and GBM tumor growth. +other 31599471 hsa-mir-1246 Leiomyosarcoma, Uterine Based on model construction, the optimal model consisted of two miRNAs (miR-1246 and miR5p), with an area under the receiver operating characteristic curve (AUC) for identifying ULMS of 0.97 (95% confidence interval [CI], 0.91-1.00). +other 31599471 hsa-mir-191 Leiomyosarcoma, Uterine Based on model construction, the optimal model consisted of two miRNAs (miR-1246 and miR5p), with an area under the receiver operating characteristic curve (AUC) for identifying ULMS of 0.97 (95% confidence interval [CI], 0.91-1.00). +lncRNA target 31599450 hsa-mir-199 Carcinoma, Hepatocellular The increase of the expression of miR-199 can inhibit the expression of Snail and inhibit the EMT process and invasion ability of hepatoma cells. +genetics_knock down_promote 31599430 hsa-mir-34a Reperfusion Injury, Cerebral Ischemia CONCLUSIONS: Our data demonstrated that the miR-34a knockdown could alleviate the brain tissue injury and neuronal apoptosis by activating the Notch1/HIF-1alpha signaling pathway CIR-treated rats. +genetics_knock down_promote 31599424 hsa-mir-1271 Thyroid Cancer, Papillary Furthermore, IRS1 was indicated as a direct target gene of miR-1271 and knockdown of IRS1 inhibited cell migration, invasion and proliferation in PTC. +lncRNA target 31599422 hsa-mir-524 Stomach Neoplasms 5p participates in the development of GC via regulating CASP3, which might provide a new prospect for GC diagnosis and therapy. +lncRNA target 31599418 hsa-mir-155 Nasopharyngeal Carcinoma CONCLUSIONS: Up-regulation of miR-155 can promote the proliferation of NPC cells and inhibit cell apoptosis by targeting the PTEN-PI3K/AKT pathway, thereby participating in the development and invasion of NPC, indicating that it might be a potential novel target for treating NPC. +genetics_knock down_promote 31599417 hsa-mir-29c Stomach Neoplasms Moreover, the knockout of CDK6 had similar effects as the miR-29c over-expression in GC cells. +genetics_knock down_suppress 31599416 hsa-mir-885 Stomach Neoplasms Notably, rescue experiments demonstrated that the knockdown of YPEL1 partially reversed the effects of miR +lncRNA target 31599414 hsa-mir-223 Pancreatic Carcinoma Inhibition of miR-223 expression upregulated FoxO3a expression, restrained pancreatic cancer cell proliferation, promoted cell apoptosis, and enhanced CDDP sensitivity in pancreatic cancer cells. +other 31599414 hsa-mir-155 Pancreatic Carcinoma This study explored whether miR-155 regulates the expression of FoxO3a and affects the proliferation, apoptosis, and cisplatin (CDDP) resistance of oral cancer cells. +genetics_overexpression_promote 31599412 hsa-mir-217 Carcinoma, Hepatocellular In cell recovery experiment, it was found that the overexpression of KLF5 could counteract the effect of microRNA-217 mimics on the cell proliferation of HCC, thereby inhibiting the malignant progression of this disease. +genetics_overexpression_promote 31599407 hsa-mir-206 Carcinoma, Renal Cell In the cell reverse experiment, the overexpression of ZEB2 was found to be able to counteract the impact of microRNA-206 mimics on RCC cell proliferation and apoptosis and thus, participated in the malignant progression of RCC. +other 31599406 hsa-mir-193a Prostatic Neoplasms The functional and mechanistical experiments unraveled that lncRNA TTN-AS1 sponged miR-193a-5p to promote cell proliferation and repress cell apoptosis in prostatic cancer, and this new regulatory pathway may shed light on the mechanism of prostatic cancer. +circulation_biomarker_diagnosis_ns 31599402 hsa-mir-365a Osteoporosis PATIENTS AND METHODS: The serum level of miRNA-365a-3p in osteoporosis patients and normal controls was determined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). +genetics_overexpression_promote 31599401 hsa-mir-498 Osteoporosis Overexpression of GAS5 promotes osteogenic differentiation of hMSCs through regulating microRNA-498 to up-regulate RUNX2 expression, thus alleviating the development of osteoporosis. +genetics_knock down_promote 31599400 hsa-mir-138 Diabetic Retinopathy 5p knockdown markedly upregulated the mRNA and protein levels of NOVA1 in EC and RP cells. +circulation_biomarker_diagnosis_ns 31598681 hsa-mir-96 Stomach Neoplasms 5p in gastric cancer cell lines and plasma samples from gastric cancer patients. +transcription factor target 31598678 hsa-mir-146a Breast Neoplasms In conclusion, miR-146 can promote the proliferation and invasion of breast cancer by targeting NM23-H1. +transcription factor target 31598678 hsa-mir-146 Breast Neoplasms In conclusion, miR-146 can promote the proliferation and invasion of breast cancer by targeting NM23-H1. +circRNA target 31598673 hsa-mir-139 Colorectal Neoplasms Collectively, this study suggested that circ_0000218 upregulated RAB1A and promoted CRC proliferation and metastasis via sponging miR +other 31598635 hsa-mir-375 Enterovirus B, Human CONCLUSION: In this study, we demonstrate that by use of the miRsensitive CVB3 variant H3N-375TS, CVB3 myocarditis can be established without the animals developing severe systemic infection and pancreatitis. +other 31598635 hsa-mir-375 Myocarditis CONCLUSION: In this study, we demonstrate that by use of the miRsensitive CVB3 variant H3N-375TS, CVB3 myocarditis can be established without the animals developing severe systemic infection and pancreatitis. +other 31598635 hsa-mir-375 Coxsackievirus Infections CONCLUSION: In this study, we demonstrate that by use of the miRsensitive CVB3 variant H3N-375TS, CVB3 myocarditis can be established without the animals developing severe systemic infection and pancreatitis. +circulation_biomarker_prognosis_up 31598374 hsa-mir-122 Stomach Neoplasms In the diagnosis and predicting prognosis of gastric cancer, receiver operating characteristic analysis revealed that the area under curve of combined detection of serum miR +exosome 31598373 hsa-mir-181b Stomach Neoplasms CONCLUSIONS: We identified exosomal miRNAs capable of distinguishing between non-malignant and GC-ascites, showing that the combined use of miR-181b-5p and CEA could improve diagnosis. +other 31598373 hsa-mir-181d Liver Neoplasms RESULTS: The miR3p, miR-181b-5p, miR-4481, and miR-181d were significantly downregulated in the GC-ascites samples compared to the LC-ascites samples, and miR-181b-5p showed the best diagnostic performance for GC-ascites (area under the curve [AUC]=0.798 and 0.846 for the training and validation cohorts, respectively). +exosome 31598373 hsa-mir-181b Liver Neoplasms CONCLUSIONS: We identified exosomal miRNAs capable of distinguishing between non-malignant and GC-ascites, showing that the combined use of miR-181b-5p and CEA could improve diagnosis. +other 31598373 hsa-mir-181d Stomach Neoplasms RESULTS: The miR3p, miR-181b-5p, miR-4481, and miR-181d were significantly downregulated in the GC-ascites samples compared to the LC-ascites samples, and miR-181b-5p showed the best diagnostic performance for GC-ascites (area under the curve [AUC]=0.798 and 0.846 for the training and validation cohorts, respectively). +other 31598373 hsa-mir-574 Stomach Neoplasms RESULTS: The miR3p, miR-181b-5p, miR-4481, and miR-181d were significantly downregulated in the GC-ascites samples compared to the LC-ascites samples, and miR-181b-5p showed the best diagnostic performance for GC-ascites (area under the curve [AUC]=0.798 and 0.846 for the training and validation cohorts, respectively). +other 31598373 hsa-mir-4481 Liver Neoplasms RESULTS: The miR3p, miR-181b-5p, miR-4481, and miR-181d were significantly downregulated in the GC-ascites samples compared to the LC-ascites samples, and miR-181b-5p showed the best diagnostic performance for GC-ascites (area under the curve [AUC]=0.798 and 0.846 for the training and validation cohorts, respectively). +other 31598373 hsa-mir-4481 Stomach Neoplasms RESULTS: The miR3p, miR-181b-5p, miR-4481, and miR-181d were significantly downregulated in the GC-ascites samples compared to the LC-ascites samples, and miR-181b-5p showed the best diagnostic performance for GC-ascites (area under the curve [AUC]=0.798 and 0.846 for the training and validation cohorts, respectively). +other 31598373 hsa-mir-574 Liver Neoplasms RESULTS: The miR3p, miR-181b-5p, miR-4481, and miR-181d were significantly downregulated in the GC-ascites samples compared to the LC-ascites samples, and miR-181b-5p showed the best diagnostic performance for GC-ascites (area under the curve [AUC]=0.798 and 0.846 for the training and validation cohorts, respectively). +circulation_biomarker_diagnosis_ns 31598147 hsa-mir-125b Hepatitis B, Chronic In conclusion, circulating microRNAs, particularly the miR-125b, may serve as promising biomarkers for the early diagnosis of HBV-related HCC. +other 31598146 hsa-mir-196a Uterine Cervical Neoplasms Our results indicated that rs4636297 in miR-126 and rs11614913 in miR-196a2 play an important role only in the initiation of cervical cancer not in the development of CIN to cervical cancer. +other 31597886 hsa-mir-29a Intracranial Aneurysm 5p was 0.773 in terms of discriminating whether the aneurysm was ruptured. +genetics_overexpression_promote 31597594 hsa-mir-1248 Sjogren's Syndrome Importantly, ITPR3, a key component of calcium signaling in epithelial cells, that has previously shown to be downregulated in SS SG, was directly targeted and downregulated by miR-1248, inducing the same functional calcium signaling changes as observed in SS SGs. INTERPRETATION: Identification of the first endogenous mammalian microRNA that binds to RIG-I inducing IFN production but also demonstrate a novel pathophysiological underlying mechanism in which miR-1248 overexpression links two major pathways associated with SS, namely activation of IFN production with modulation of calcium signaling. +lncRNA target 31597523 hsa-mir-149 Carcinoma, Non-Small-Cell Lung Therefore, our data suggest that circHIPK3 regulates the function of NSCLCs through miRmediated FOXM1 expression regulation, potentially providing a novel insight into the pathogenesis of NSCLC. +circulation_biomarker_diagnosis_ns 31597449 hsa-mir-92a Vascular Diseases Furthermore, an inverse correlation of intravesicular miR-92a in blood serum and KLF4 expression in lesions was observed in atherosclerotic animals, indicating the potential function of extracellular miR-92a in regulating vascular diseases. +circulation_biomarker_diagnosis_ns 31597402 hsa-mir-373 Testicular Neoplasms 3p were evaluated in serum of metastatic TGCC patients. +circulation_biomarker_diagnosis_ns 31597402 hsa-mir-371a Testicular Neoplasms 3p were evaluated in serum of metastatic TGCC patients. +circulation_biomarker_diagnosis_ns 31597402 hsa-mir-367 Testicular Neoplasms 3p were evaluated in serum of metastatic TGCC patients. +other 31597292 hsa-mir-10a Gonadotoxicity Given the controversial role of miR-10a in the ovarian function, we decided to investigate its implication in chemotherapy-induced gonadotoxicity. +other 31596872 hsa-mir-382 Stomach Neoplasms In addition, miR-382 give a predictive marker for progression of GCs compared to the normal or preneoplastic lesion. +other 31596872 hsa-mir-210 Stomach Neoplasms In paired 60 gastric normal and cancer tissues, miR-382 expression in cancer tissues was significantly higher than normal counterpart (p = 0.003), but not miR-210 expression. +other 31596588 hsa-mir-145 Colorectal Neoplasms MIR145-5p, a representative TS-miRNA especially in colorectal cancer, was selected. +transcription factor target 31596512 hsa-mir-27b Heart Diseases Finally, the modulation of gpr126 expression in zebrafish by injection of either miR-27b or miR-27b inhibitor in single cell-stage embryos resulted in hypo- or hypertrabeculation, respectively. +other 31596136 hsa-mir-486 Plaque, Atherosclerotic 5p whose role in atherosclerosis requires further investigation. +other 31595632 hsa-mir-326 Obesity Our results highlight the importance of miR-326 in adipogenic differentiation and provide a reliable basis for clinical treatment of adipose-related diseases. +genetics_GWAS 31595574 hsa-mir-145 Endometriosis MiR-145 has been shown to suppress cell invasiveness and proliferation in endometriosis, whereas prostate cancer-associated transcript 1 (PCAT1) was reported to act as a sponge of miR-145 with one single-nucleotide polymorphism (SNP), rs710886, located in the chromosomal segment of PCAT1. +other 31595567 hsa-mir-155 Breast Neoplasms 5p was significantly up-regulated in BC tumor tissues compared with the corresponding adjacent normal tissues. +other 31595567 hsa-mir-127 Breast Neoplasms 5p was significantly up-regulated in BC tumor tissues compared with the corresponding adjacent normal tissues. +other 31595567 hsa-mir-342 Breast Neoplasms 5p was significantly up-regulated in BC tumor tissues compared with the corresponding adjacent normal tissues. +other 31595567 hsa-mir-199b Breast Neoplasms 5p was significantly up-regulated in BC tumor tissues compared with the corresponding adjacent normal tissues. +other 31595567 hsa-mir-133a Breast Neoplasms 5p was significantly up-regulated in BC tumor tissues compared with the corresponding adjacent normal tissues. +lncRNA target 31595566 hsa-mir-125a Carcinoma, Non-Small-Cell Lung METHOD: Real-time polymerase chain reaction was performed to identify potential lncRNAs involved in the chemoresistance of NSCLC, while in-silicon analyses and luciferase assays were carried out to explore the regulatory relationship among ANRIL, miR-125a, and aminopeptidase N (APN). CONCLUSION: The data of this study suggested that, by targeting ANRIL and the APN signaling pathway, miR-125a inhibited the proliferation of NSCLC cells and promoted their apoptosis, thus attenuating the chemoresistance of NSCLC against Ubenimex. +lncRNA target 31595563 hsa-mir-19a Hunner-Type Interstitial Cystitis The area under the curve of MEG3 was larger than that of miR-19a-3p, indicating that MEG3 has a better value in the diagnosis of HIC. In addition, patients with HIC showed elevated MEG3 expression and inhibited miR-19a-3p expression, thus establishing a negative correlation between MEG3 and miR-19a-3p. +other 31595560 hsa-let-7 Breast Neoplasms Our study uncovers the role of the LIN28A/Let-7 in BrCSCs renewal, and more importantly, elucidated a novel mechanism by which Matrine induces breast cancer involution. +genetics_overexpression_suppress 31595558 hsa-mir-1827 Adenocarcinoma of Lung Overexpression of MYC or FAM83F attenuated the effects of miR-1827 on primary lung adenocarcinoma cells in vitro. +transcription factor target 31595425 hsa-mir-26 Carcinoma, Renal Cell Wound healing and transwell assay revealed that miR-26 inhibited migration and invasion of renal cancer cell. +lncRNA target 31595421 hsa-mir-507 Carcinoma, Non-Small-Cell Lung Mechanically, LINC00243 acted as a molecular sponge for miR-507, and miR-507 reversed the effect of LINC00243 on promoting proliferation and glycolysis of NSCLC cells. LINC00243 promotes proliferation and glycolysis in NSCLC cells by positively regulating PDK4 through sponging miR-507. +exosome 31595161 hsa-mir-155 Uterine Cervical Neoplasms Results: Exosomal miR +exosome 31595150 hsa-mir-139 Stomach Neoplasms Thus, we propose that exosomal miR-139 derived from gastric CAFs could inhibit the progression and metastasis of gastric cancer by decreasing MMP11 in tumor microenvironment. +virus_miRNA 31594754 ebv-mir-BART22 Nasopharyngeal Carcinoma Cinobufotalin powerfully reversed EBV-miR-BART22-induced cisplatin resistance via stimulating MAP2K4 to antagonize non-muscle myosin heavy chain IIA/glycogen synthase 3β/β-catenin signaling pathway +genetics_knock down_promote 31594210 hsa-mir-222 Leukemia, Lymphocytic, Chronic, B-Cell A qRT-PCR assay was used to examine the levels of lncRNA GAS5 and miR-222 in leukomonocytes of patients with B lymphocytic leukaemia and in healthy donors. +circulation_biomarker_prognosis_ns 31594209 hsa-mir-10b Leukemia, Myeloid, Acute CONCLUSIONS: Taken together, serum EV-miR-10b might serve as a promising biomarker for predicting the prognosis of AML. +lncRNA target 31593832 hsa-mir-942 Pulmonary Arterial Hypertension In summary, the results of this study suggested that hsa_circ_0016070 was associated with vascular remodeling in PAH by promoting the proliferation of pulmonary artery smooth muscle cells (PASMCs) via the miR-942/CCND1. +other 31593646 hsa-mir-200a Pre-Eclampsia 3p and miR-200a-3p in regulating TTR during trophoblast dysfunction and PE development. +other 31593646 hsa-mir-141 Pre-Eclampsia 3p and miR-200a-3p in regulating TTR during trophoblast dysfunction and PE development. +lncRNA target 31593640 hsa-mir-26a Fibrosis, Renal Exogenous miR-26a suppresses muscle wasting and renal fibrosis in obstructive kidney disease. +lncRNA target 31593640 hsa-mir-26a Obstructive Kidney Disease Exogenous miR-26a suppresses muscle wasting and renal fibrosis in obstructive kidney disease. +genetics_overexpression_promote 31593552 hsa-mir-16 Multiple Myeloma Finally, we demonstrate the therapeutic benefit of miR-16 overexpression in potentiating the anti-MM activity by a proteasome inhibitor in the presence of MM-resident bone marrow TAM. +other 31593492 hsa-mir-181 Parkinson Disease Our study showed that aberrant expression of ISG15, RRM2, FBXW11, FOXM1, and MIR-181 family were associated with pathological processes in PD, and they could be the research focuses to further investigate the mechanism of PD. +lncRNA target 31593333 hsa-mir-125a Inflammation BIL inhibited ILinduced inflammatory injury in ATDC5 cells by downregulation of miR-125a via JNK and NF-kappaB signaling pathways. +other 31592314 hsa-mir-21 Lewy Body Disease 3p, hsa-let-7i-5p, and hsa-miR-151a-3p) significantly decreased in AD respect to controls. +other 31592314 hsa-mir-126 Alzheimer Disease 3p, hsa-let-7i-5p, and hsa-miR-151a-3p) significantly decreased in AD respect to controls. +other 31592314 hsa-mir-451a Lewy Body Disease 3p, hsa-let-7i-5p, and hsa-miR-151a-3p) significantly decreased in AD respect to controls. +other 31592314 hsa-mir-151a Lewy Body Disease 3p, hsa-let-7i-5p, and hsa-miR-151a-3p) significantly decreased in AD respect to controls. +other 31592314 hsa-mir-151a Alzheimer Disease 3p, hsa-let-7i-5p, and hsa-miR-151a-3p) significantly decreased in AD respect to controls. +other 31592314 hsa-mir-21 Alzheimer Disease 3p, hsa-let-7i-5p, and hsa-miR-151a-3p) significantly decreased in AD respect to controls. +other 31592314 hsa-mir-126 Lewy Body Disease 3p, hsa-let-7i-5p, and hsa-miR-151a-3p) significantly decreased in AD respect to controls. +other 31592314 hsa-mir-451a Alzheimer Disease 3p, hsa-let-7i-5p, and hsa-miR-151a-3p) significantly decreased in AD respect to controls. +other 31592314 hsa-mir-23a Alzheimer Disease 3p, hsa-let-7i-5p, and hsa-miR-151a-3p) significantly decreased in AD respect to controls. +other 31592314 hsa-mir-23a Lewy Body Disease 3p, hsa-let-7i-5p, and hsa-miR-151a-3p) significantly decreased in AD respect to controls. +genetics_knock down_promote 31592231 hsa-mir-10b Stomach Neoplasms The knockdown of microRNA-10b expression inhibited cell proliferation in GC cells in vitro and tumor growth in vivo. +exosome 31592229 hsa-mir-22 Transmissible Gastroenteritis The data revealed that TGEV-induced mPTP opening was regulated via two pathways: circEZH2/miR-22/HK2 axis and circEZH2/miR-22/IL-6/NF-kappaB axis. +transcription factor target 31592115 hsa-mir-17 Arthritis, Rheumatoid We further show that the RIDD targets (miRNA-17, -34a, -96, and -125b) were downregulated in RA samples. +exosome 31591913 hsa-mir-320d Atrial Fibrillation Taken together, the results suggested that exosomal miR-320d was associated with AF cardiomyocytes apoptosis and cell viability and that the effect of miR-320d on cardiomyocytes is STAT3-dependent. +genetics_overexpression_promote 31591389 hsa-mir-92a Lung Neoplasms Lung cancer-derived EVs induced transcription of the pri-miR-92a gene, resulting in the overexpression of mature miR-19b and miR-92a in recipient bronchial cells. These data support the role of c-Myc shuttling in lung cancer-derived EVs in inducing the upregulation of onco-miR-19b and miR-92a expression with concomitant impairment of the TGFB signalling pathway in recipient cells. +genetics_overexpression_promote 31591389 hsa-mir-19b Lung Neoplasms Lung cancer-derived EVs induced transcription of the pri-miR-92a gene, resulting in the overexpression of mature miR-19b and miR-92a in recipient bronchial cells. These data support the role of c-Myc shuttling in lung cancer-derived EVs in inducing the upregulation of onco-miR-19b and miR-92a expression with concomitant impairment of the TGFB signalling pathway in recipient cells. +lncRNA target 31590919 hsa-mir-335 Thyroid Cancer, Papillary Besides, we confirmed that SHH was a target of miR-335 and miR-335 over-expression distinctly reduced SHH expression in PTC cells. Taken together, our findings revealed that the newly identified LINC01510/miR-335/SHH axis could be a therapeutic target for PTC. +transcription factor target 31590696 hsa-mir-541 Cholangiocarcinoma CONCLUSIONS: Our findings uncover that CyclinD1 inhibits Dicer expression by chromatin modification to reduce miR +transcription factor target 31590696 hsa-mir-1914 Cholangiocarcinoma CONCLUSIONS: Our findings uncover that CyclinD1 inhibits Dicer expression by chromatin modification to reduce miR +circulation_biomarker_diagnosis_ns 31590680 hsa-mir-192 Uterine Cervical Neoplasms METHODS: The expression levels of tissue and serum miRNAs, including miR-9, miR-192 and miR-205, were investigated in 36 normal, 18 precancer, and 18 cervical cancer samples using real-time polymerase chain reaction. CONCLUSIONS: Given the increased expression level of miR-192 in cancer and in precancerous tissue and serum compared with the normal tissue and serum validated by analysing the ROC curve, miR-192 can be used as potential biomarker for the early detection of cervical cancer. +lncRNA target 31590627 hsa-mir-148a Uterine Cervical Neoplasms In conclusion, SNHG4 could be used as a competitive endogenous RNA to bind to miR-148a-3p, thereby up-regulating the expression of c-Met and ultimately promoting the progression of CC, which provided a potential therapeutic target for the targeted treatment of CC. +lncRNA target 31590125 hsa-mir-637 Squamous Cell Carcinoma of Head and Neck Collectively, our research shows that LINC01234 exerts an important role in OSCC progression via miR-637/NUPR1 axis. +lncRNA target 31590045 hsa-mir-144 Retinal Degeneration Collectively, the present work establishes miR-144 as a potential target for preventing and treating degenerative retinal diseases in which oxidative stress is paramount and RPE is prominently affected (e.g., age-related macular degeneration and diabetic retinopathy). +genetics_overexpression_promote 31589818 hsa-mir-139 Colorectal Neoplasms 5p as a tumor suppressor gene overexpressed in CRC that assisted in inhibiting progression of cancer. +lncRNA target 31588838 hsa-mir-99b Arthritis, Rheumatoid The over-expression of newly discovered miR-99b-5p is able to suppress T cell apoptosis, promote cell proliferation and activation, increase expression of proinflammatory cytokines (IL-2, IL-6, TNF-alpha, and IFN-gamma), and inhibit expression of its target genes mTOR and RASSF4. +exosome 31588496 hsa-mir-548e Behcet Syndrome Collectively, these data show that exosomal miR-146a-5p and miR-548e-5p from AF-MSCs have anti-inflammatory effects on human trophoblast cells and may be novel targets for treating inflammatory diseases and associated problems that occur during pregnancy, such as PB. +exosome 31588496 hsa-mir-548e Inflammation Collectively, these data show that exosomal miR-146a-5p and miR-548e-5p from AF-MSCs have anti-inflammatory effects on human trophoblast cells and may be novel targets for treating inflammatory diseases and associated problems that occur during pregnancy, such as PB. +exosome 31588496 hsa-mir-146a Inflammation Collectively, these data show that exosomal miR-146a-5p and miR-548e-5p from AF-MSCs have anti-inflammatory effects on human trophoblast cells and may be novel targets for treating inflammatory diseases and associated problems that occur during pregnancy, such as PB. +circulation_biomarker_diagnosis_down 31588188 hsa-mir-92b Colorectal Neoplasms Taken together, our findings indicated that decreased expression of exosome-derived miR-92b in plasma is a promising biomarker for early detection of CRC. +lncRNA target 31588120 hsa-mir-339 Pancreatic Carcinoma 5p suppresses the invasion and migration of pancreatic cancer cells via direct regulation of ZNF689 in vitro. +lncRNA target 31587871 hsa-mir-221 Diabetes, Gestational MiRNA-221 regulates proliferation, apoptosis and insulin secretion in islet beta cells through targeting PAK1, thus protecting GDM-induced islet dysfunction. +other 31587805 hsa-mir-942 Infertility, Male 3p have the potential to become new molecular biomarkers that could help to diagnose male infertility, especially in cases of UMI or when seminal parameters are close to the threshold values. +other 31587805 hsa-mir-139 Infertility, Male 3p (UMI). +other 31587805 hsa-mir-1260a Infertility, Male 3p (UMI). +other 31587805 hsa-mir-28 Infertility, Male 3p (UMI). +other 31587805 hsa-mir-1208 Infertility, Male 3p have the potential to become new molecular biomarkers that could help to diagnose male infertility, especially in cases of UMI or when seminal parameters are close to the threshold values. +other 31587805 hsa-mir-296 Infertility, Male 3p (UMI). +other 31587805 hsa-mir-34b Infertility, Male 3p have the potential to become new molecular biomarkers that could help to diagnose male infertility, especially in cases of UMI or when seminal parameters are close to the threshold values. +other 31587805 hsa-mir-93 Infertility, Male 3p have the potential to become new molecular biomarkers that could help to diagnose male infertility, especially in cases of UMI or when seminal parameters are close to the threshold values. +lncRNA target 31587482 hsa-mir-99a Urinary Bladder Neoplasms Finally, pretreatment with the ERK inhibitor U0126 diminished c-Jun phosphorylation and transcriptional activation, suggesting that BITC elicits ERK/c-Jun signal transduction, which is responsible for miR-99a expression in bladder cancer. +lncRNA target 31587474 hsa-mir-7 Carcinoma, Non-Small-Cell Lung 5p was associated with poor prognosis and NSCLC progression by directly targeting PAK2. +lncRNA target 31587336 hsa-mir-574 Uterine Cervical Neoplasms Taken together, lncRNA PTCSC3 inhibited cell growth and metastasis via sponging miR +other 31587286 hsa-mir-663 Thyroid Cancer, Papillary 3p/RGS4 in PTC cell lines. +genetics_GWAS 31586698 hsa-mir-137 Schizophrenia The Schizophrenia Psychiatric GWAS Consortium (PGC) has identified the rs1625579 polymorphism in the MIR137 gene, which encodes miR-137, as the strongest new association with schizophrenia in the European population. Our meta-analysis found that the Rs1625579 polymorphism in the MIR137 gene was associated with the risk of schizophrenia. +genetics_overexpression_promote 31586299 hsa-mir-384 Breast Neoplasms We used bioinformatics prediction and functional assay validation to determine that SNHG3 upregulation inhibited miR-384 activity and led to hepatoma-derived growth factor (HDGF) overexpression in breast cancer cells. The findings of this study show that SNHG3 functions as an oncogene in breast cancer and promotes breast cancer cell proliferation and invasion by regulating the miR-384/HDGF axis. +other 31586203 hsa-mir-203 Ovarian Neoplasms In this regard, miR-203 expression constitutes a novel independent molecular marker to improve patients' prognosis in OC. +transcription factor target 31586077 hsa-mir-21 Inflammation Engulfment of apoptotic cells by macrophages (efferocytosis) resolves inflammation via a miRPDCD4-IL-10 pathway. +genetics_GWAS 31585905 hsa-mir-145 Atherosclerosis To this end, we examined whether AS is associated with the miR-145 rs353291 polymorphism and specific rs353291 alleles. +lncRNA target 31585904 hsa-mir-126 Thyroid Neoplasms Taken together, these results indicate that silencing NEAT1 suppresses thyroid carcinoma via miR-126/NEAT1/VEGFA axis. +genetics_knock down_promote 31585896 hsa-mir-1 Stomach Neoplasms In addition, while overexpression of miR-1 suppressed the expression of Sorcin, the siRNA knockdown of Sorcin significantly counteracted the effect of miR-1 inhibitor on cell invasion and migration of gastric cancer cells. +other 31585800 hsa-mir-223 Liver Injury Our data enlightens miR-223 3p as a post-transcriptional approach to treat acute and chronic hepatitis by silencing the activation of the NLRP3 inflammasome. +lncRNA target 31585570 hsa-mir-378 hereditary diffuse gastric cancer For early detection and diagnosis of gastric cancer, a novel, highly sensitive detection of microRNA-378 was developed through rolling circle amplification and DNA-templated silver nanoclusters as a lable-free fluorescent probe. +genetics_overexpression_promote 31585536 hsa-mir-21 Enterovirus B, Human CONCLUSIONS: miRNA-21 were reverse correlated with P38 MAPK activation post CVB3 infection, miRNA-21 overexpression significantly inhibited viral progeny release and decreased myocytes apoptosis rate in vitro and in vivo, suggesting that miRNA-21 may serve as a potential therapeutic agent against CVB3 infection through targeting the MAP2K3/P38 MAPK signaling. +lncRNA target 31585300 hsa-mir-650 Lung Neoplasms Our data suggested MEG3 was involved in stem cell-like state of LCCs and curbed migration and invasion through miR-650/SLC34A2 axis in NSCLC. +other 31584877 hsa-mir-494 pancreatic adenocarcinoma The expression of CXCR4, HIF1A, ZEB1, and SDC1 in PAAD was regulated by circ-UBAP2 and hsa-miR-494. +lncRNA target 31584290 hsa-mir-497 Esophageal Squamous Cell Carcinoma Conclusions: LINC00473 regulates ESCC progression through miR +other 31583946 hsa-mir-21 Breast Neoplasms This study investigated the effects of anti-microRNA-21 (miR-21) AMO modified with CLDs on breast cancer cells without using reporter assay. +circulation_biomarker_diagnosis_up 31583932 hsa-mir-146b Inflammation Moreover, re-expression of miR-146b suppressed the production of inflammatory factors in the serum of pneumonia patients and WI-38 cells treated with LPS. +circulation_biomarker_diagnosis_up 31583932 hsa-mir-146b Pneumonia Moreover, re-expression of miR-146b suppressed the production of inflammatory factors in the serum of pneumonia patients and WI-38 cells treated with LPS. +other 31583913 hsa-mir-1297 Squamous Cell Carcinoma of Head and Neck Thus, these results suggest that propofol exhibits antitumour effects in OSCC cells and that the FoxO1-GAS5-miRGSK3beta axis plays an important role in propofol-induced OSCC cell apoptosis. +circulation_biomarker_diagnosis_up 31583766 hsa-mir-27a Mucocutaneous Lymph Node Syndrome The miR-27a-3p expression was markedly up-regulated during the acute phrase of KD, and it promoted monocyte-mediated TNF-alpha release by negatively regulating expression of cytoplasmic IL-10 within B cells in vitro. The data suggest up-regulated miR-27a in B cells from patients with KD may promote monocyte-mediated inflammatory responses by inhibiting the regulatory function of B10 cells. +exosome 31583718 hsa-mir-21 Spinal Cord Injuries PTENP1 is involved in the recovery of SCI by regulating the expression of miR-19b and miR-21, and exosomes from PTENP1-shRNA-transfected cells may be used as a novel biomarker in SCI treatment. +exosome 31583718 hsa-mir-19b Spinal Cord Injuries PTENP1 is involved in the recovery of SCI by regulating the expression of miR-19b and miR-21, and exosomes from PTENP1-shRNA-transfected cells may be used as a novel biomarker in SCI treatment. +other 31583475 hsa-mir-103a Diabetes Mellitus, Type 2 AIMS: MicroRNA-103 (miR-103) family plays important roles in regulating glucose homeostasis in type 2 diabetes mellitus (DM2). +circulation_biomarker_diagnosis_ns 31583475 hsa-mir-103b Diabetes Mellitus, Type 2 CONCLUSIONS: These findings suggest that circulating miR-103a and miR-103b may serve as novel biomarkers for diagnosis of DM2, providing novel insight into the mechanisms underlying pre-DM. +other 31583475 hsa-mir-103 Diabetes Mellitus, Type 2 AIMS: MicroRNA-103 (miR-103) family plays important roles in regulating glucose homeostasis in type 2 diabetes mellitus (DM2). +other 31583464 hsa-mir-1849 Periodontal Cyst MicroRNAs miR390-5p, miR7694-3p miR1868 and miR1849 were found to be suitable miRNA reference genes for rice, under either infection with the root-knot nematode Meloidogyne graminicola or treatment with BABA. +other 31583464 hsa-mir-390 Periodontal Cyst MicroRNAs miR390-5p, miR7694-3p miR1868 and miR1849 were found to be suitable miRNA reference genes for rice, under either infection with the root-knot nematode Meloidogyne graminicola or treatment with BABA. +other 31583464 hsa-mir-1868 Periodontal Cyst MicroRNAs miR390-5p, miR7694-3p miR1868 and miR1849 were found to be suitable miRNA reference genes for rice, under either infection with the root-knot nematode Meloidogyne graminicola or treatment with BABA. +other 31583464 hsa-mir-7694 Periodontal Cyst MicroRNAs miR390-5p, miR7694-3p miR1868 and miR1849 were found to be suitable miRNA reference genes for rice, under either infection with the root-knot nematode Meloidogyne graminicola or treatment with BABA. +genetics_overexpression_promote 31583047 hsa-mir-145 Myocardial Reperfusion Injury In summary, overexpression of miR-145 alleviates I/R-induced myocardial electrophysiological instability and apoptotic and inflammatory response via inhibition of the CaMKII-mediated ASK1 antiapoptotic pathway and NF-kappaB p65 anti-inflammatory pathways. +genetics_GWAS 31583029 hsa-mir-34b Neuroblastoma We hypothesize that polymorphism in the miR-34b/c gene might predispose to neuroblastoma. +other 31582977 hsa-mir-181a Diabetes Mellitus, Type 1 Bioinformatics analysis suggested that miR-21, miR-25, miR-146a, and miR-181a regulated multiple genes in pathways associated with immunity, inflammatory responses, hyperglycemia, and metabolism, which are involved in the pathogenesis of autoimmune diabetes. +circulation_biomarker_diagnosis_down 31582977 hsa-mir-146a Diabetes Mellitus, Type 1 RESULTS: miR-21, miR-25, miR-146a, and miR-181a were significantly downregulated in the serum of patients with autoimmune diabetes compared with those in T2D patients and nondiabetic individuals (p < 0.001). +other 31582977 hsa-mir-21 Diabetes Mellitus, Type 1 Bioinformatics analysis suggested that miR-21, miR-25, miR-146a, and miR-181a regulated multiple genes in pathways associated with immunity, inflammatory responses, hyperglycemia, and metabolism, which are involved in the pathogenesis of autoimmune diabetes. +circulation_biomarker_diagnosis_down 31582977 hsa-mir-25 Diabetes Mellitus, Type 1 RESULTS: miR-21, miR-25, miR-146a, and miR-181a were significantly downregulated in the serum of patients with autoimmune diabetes compared with those in T2D patients and nondiabetic individuals (p < 0.001). +lncRNA target 31582908 hsa-mir-7 Nasopharyngeal Carcinoma 5p and E2F3, suggesting CircRNA CDR1as as a potential target for the treatment of NPC patients.Trial registration The study was approved by the cancer center's institutional research ethics committee on Oct 18, 2008 (2008GZ2847462). +lncRNA target 31582906 hsa-mir-145 Esophageal Squamous Cell Carcinoma CONCLUSION: miR-145 increased the sensitivity of ESCC to DDP, and facilitated DDP-induced apoptosis, cycle arrest by directly inhibiting PI3K/AKT signaling pathway to decrease multidrug resistance-associated proteins MRP1 and P-gp expression. +other 31582895 hsa-mir-7 Periodontitis Taken together, our findings revealed the effects of the interacting pair of CDR1as/miR-7 on the proliferation ability of PDLSCs within their surrounding inflammatory microenvironment of periodontitis. +circulation_biomarker_diagnosis_up 31582779 hsa-mir-4484 Scleroderma, Systemic We identified that miR-4484, located on chromosome 10q26.2, was an 18-fold up-regulated in SSc patients compared to a control group. Our results suggest that miR-4484, and MMP-21 might be novel serum biomarkers that may correspond to pathological fibrosis in SSc, but it needs to be validated in further studies. +circRNA target 31582722 hsa-mir-182 Intervertebral Disc Degeneration 5p/SIRT1 axis by activating mitophagy and inhibiting apoptosis, and suggests that circERCC2 is a potentially effective therapeutic target for IVDD. +lncRNA target 31582214 hsa-mir-519b Adenocarcinoma of Lung Taken together, all the results indicated that LINC01419 exhibited oncogenic behaviors LUAD via binding to miR-519b-3p to enhance the expression of RCCD1, manifesting the underlying therapy values of LINC01419 in LUAD. +lncRNA target 31582213 hsa-mir-1299 Prolactinoma These results indicate that FOXO1 and miR-1299 are potential therapeutic targets for drug-resistant prolactinoma as well as other pituitary diseases. +lncRNA target 31582211 hsa-mir-204 Pre-Eclampsia Result of protein were observed in pre-eclampsia (+) group compared with pre-eclampsia (-) group, while miR-204 level in pre-eclampsia (+) group was significantly lower than pre-eclampsia (-) group. Taken together, we found that administration of metformin prevents pre-eclampsia by suppressing migration of trophoblast cells via modulating the signaling pathway of UCA1/miR-204/MMP-9. +other 31581940 hsa-mir-106b Breast Neoplasms 5p and miR-20a-5p were significantly lower in luminal A tumors. +other 31581940 hsa-mir-20a Breast Neoplasms 5p and miR-20a-5p were significantly lower in luminal A tumors. +lncRNA target 31581360 hsa-mir-195 Lung Neoplasms These findings demonstrate that miR-195 and miR-497 act as a tumor suppressor by suppressing ubiquitination-mediated degradation of TGF-beta receptors through SMURF2, and suggest that miR-195 and miR-497 are potential therapeutic targets for lung cancer. +lncRNA target 31581360 hsa-mir-497 Lung Neoplasms These findings demonstrate that miR-195 and miR-497 act as a tumor suppressor by suppressing ubiquitination-mediated degradation of TGF-beta receptors through SMURF2, and suggest that miR-195 and miR-497 are potential therapeutic targets for lung cancer. +other 31581132 hsa-mir-1270 Carcinoma, Hepatocellular Mechanistically, we found that Cdr1as could promote the expression of AFP, a well-known biomarker for HCC, by sponging miR-1270. +other 31581131 hsa-mir-2467 Carcinoma, Ovarian Epithelial In summary, our findings demonstrate that SNHG22 plays a critical role in the chemotherapy resistance of EOC by mediating the miR-2467/Gal-1 regulatory axis. +genetics_overexpression_suppress 31579977 hsa-mir-206 Carcinoma, Hepatocellular miRNA-206 overexpression had similar effects in HCC cell lines (Bel-7402 and Huh-7). RMRP downregulation inhibits HCC-related biological activities by the regulation of miRNA-206/TACR1. +other 31579840 hsa-mir-29 Acute Coronary Syndrome 5p were associated with both echocardiographic markers of cardiac remodeling and prevalent HF. +other 31579840 hsa-mir-584 Acute Coronary Syndrome 5p were associated with echocardiographic phenotypes and prevalent HF and are potential biomarkers for adverse cardiac remodeling in HF. +other 31579840 hsa-mir-584 Heart Failure 5p were associated with echocardiographic phenotypes and prevalent HF and are potential biomarkers for adverse cardiac remodeling in HF. +other 31579840 hsa-mir-1247 Heart Failure 5p were associated with echocardiographic phenotypes and prevalent HF and are potential biomarkers for adverse cardiac remodeling in HF. +other 31579840 hsa-mir-1247 Acute Coronary Syndrome 5p were associated with echocardiographic phenotypes and prevalent HF and are potential biomarkers for adverse cardiac remodeling in HF. +other 31579840 hsa-mir-29 Heart Failure 5p were associated with both echocardiographic markers of cardiac remodeling and prevalent HF. +lncRNA target 31579605 hsa-mir-10b Breast Neoplasms Taken together, our data suggest that miR-10b-5p functions to impede breast carcinoma progression via regulation of its key target genes and hopefully serves as a potential diagnostic and prognostic marker for breast cancer. +other 31579447 hsa-mir-96 Carcinoma, Non-Small-Cell Lung In addition, miR-96 indeed induced migration, invasion and proliferation of NSCLC cell line. +genetics_overexpression_promote 31579422 hsa-mir-544 Esophageal Squamous Cell Carcinoma More importantly, overexpression of miR-544 led to increased sensitivity of ESCC cells to cisplatin, an anticancer drug. +other 31579415 hsa-mir-22 Prostatic Neoplasms Two triplets (MIR22HG_hsa-mir-21_TGFBR2 and MIR22HG_hsa-mir-21_BCL2) were finally identified; not only were they significantly associated with PRAD survival but they also had the highest average degree in the identified subnetwork. +other 31579415 hsa-mir-21 Prostatic Neoplasms Two triplets (MIR22HG_hsa-mir-21_TGFBR2 and MIR22HG_hsa-mir-21_BCL2) were finally identified; not only were they significantly associated with PRAD survival but they also had the highest average degree in the identified subnetwork. +genetics_overexpression_suppress 31579409 hsa-mir-23a Endometrial Neoplasms miR-23a was underexpressed in endometrial cancer tissues compared with in para-carcinoma tissues, and the overexpression of miR-23a inhibited proliferation and invasion of endometrial cancer cells. +other 31579407 hsa-mir-193b Osteosarcoma The binding of miR-193b-3p to LINC00152 was demonstrated by dual-luciferase assay, and led to miR-193b-3p downregulation in osteosarcoma cells. These results suggested that LINC00152 binds to miR-193b-3p and reduces its expression level, leading to increased cell proliferation and decreased G0/G1 cell cycle arrest and apoptosis in osteosarcoma cells. +genetics_overexpression_promote 31579252 hsa-mir-155 Breast Neoplasms miR-155, a predicted modulator of CADM1 was reported to be overexpressed in breast cancer, and its high expression level was closely related to the malignant progression of breast cancer. +transcription factor target 31579095 hsa-mir-98 Carcinoma, Non-Small-Cell Lung 5p may inhibit the progression of NSCLC via targeting of MAP4K3. +genetics_overexpression_promote 31579087 hsa-mir-873 Triple Negative Breast Neoplasms Herein, using cell viability assays, the present study demonstrated that overexpression of miR-873 sensitized triple-negative breast cancer (TNBC) cells (MDA-MB-231 and BT549) towards gemcitabine treatment, while inhibition of miR-873 promoted resistance of TNBC cells to gemcitabine exposure. In conclusion, the data obtained by the present study demonstrated that the decrease of miR-873 promoted the development of gemcitabine resistance in TNBC via elevation of ZEB1 expression, which indicated that miR-873 may be a promising predictor for gemcitabine sensitivity in patients with TNBC. +transcription factor target 31579069 hsa-mir-361 Colorectal Neoplasms miR-361 may serve as a potential therapeutic target for patients with CRC. +lncRNA target 31578932 hsa-mir-17 Thyroid Carcinoma, Anaplastic Thus, targeting miR92 could provide a potential molecular approach to restoring thyroid cell differentiation and NIS expression in aggressive thyroid cancer. +other 31578816 hsa-mir-200a Squamous Cell Carcinoma of Head and Neck Finally, after adjusting for other important prognostic confounders, patients with high expression of miR-200a-3p, miR-30b-5p and miR-4451 had significantly high risk of overall death and death owing to HSCC and patients with a high-risk score has approximately 2-fold increased risk in overall death and death owing to HSCC compared with those with a low-risk score. +other 31578816 hsa-mir-4451 Squamous Cell Carcinoma of Head and Neck Finally, after adjusting for other important prognostic confounders, patients with high expression of miR-200a-3p, miR-30b-5p and miR-4451 had significantly high risk of overall death and death owing to HSCC and patients with a high-risk score has approximately 2-fold increased risk in overall death and death owing to HSCC compared with those with a low-risk score. +lncRNA target 31578772 hsa-mir-205 Breast Neoplasms 3p in breast cancer tissues and para-carcinoma tissues were detected via quantitative PCR (qPCR). +genetics_overexpression_suppress 31578454 hsa-mir-613 Melanoma Taken together, CDC7 overexpression and downregulation of miR3p were associated with Vemurafenib resistance in BRAF(V600E)- bearing melanoma cells. +circulation_biomarker_diagnosis_up 31578374 hsa-mir-486 Rhabdomyosarcoma 1 Analysis of human serum samples showed that miR +exosome 31578374 hsa-mir-486 Macular Degeneration Analysis of human RMS cells showed miR5p is enriched in both cells and exosomes, and to a higher extent in ARMS subtypes. +transcription factor target 31578016 hsa-mir-223 Macular Degeneration CONCLUSION: Baicalin alleviates intracellular pyroptosis and viability damage resulted from Abeta inducement in human retinal pigment epithelium cells via negative crosstalk of miR-223/NLRP3 in fl ammasome signaling, indicating that baicalin may be considered as a potential candidate for AMD therapy. +lncRNA target 31578014 hsa-mir-449a Uterine Cervical Neoplasms CONCLUSION: All of the results revealed that miR-449a functions as a suppressor gene and inhibits cell proliferation, migration, and invasion in cervical cancer. +other 31577754 hsa-mir-146a Diabetes Mellitus CONCLUSION: In conclusion, this meta-analysis indicated that miRNA27a rs895819 might play a protective role in diabetes, and miRNA146a rs2910164 likely had no association with diabetes. +genetics_overexpression_suppress 31576658 hsa-mir-1914 Carcinoma, Hepatocellular Furthermore, the overexpression of lncRNA DUXAP10 negatively correlated with the expression of miR-1914 in HCC; thus, lncRNA DUXAP10 regulated miR-1914 expression and modulated the GPR39/PI3K/AKT-mediated cellular behaviours. +other 31576518 hsa-mir-27 Myocarditis However, whether miR-27 involves in myocarditis development and the possible molecular mechanism remain unknown. +other 31576172 hsa-mir-153-1 Colorectal Neoplasms 1 axis in CRC. +genetics_knock down_suppress 31576148 hsa-mir-625 Glioma Our study demonstrated that the knockdown of RHPN1-AS1 inhibited the proliferation, migration and invasion activity of glioma cells via regulating miR5p/REG3A expression. +other 31576144 hsa-mir-665 Stomach Neoplasms LINC00565 can be used as the sponge of miR-665 to up-regulate the expression of AKT3, thus promoting the progression of GC. +genetics_knock down_promote 31576138 hsa-mir-19a Osteosarcoma Knockdown miR-19a inhibited osteosarcoma cell epithelial-mesenchymal transition (EMT) and suppressed osteosarcoma xenograft growth. +transcription factor target 31576124 hsa-mir-27a Obesity As miRNA dysregulation is often associated with various disease patterns, such as obesity, miRNA-27a might therefore be a promising candidate for miRNA mimic replacement therapy by inhibiting adipogenic marker genes. +other 31575652 hsa-mir-922 Multiple Sclerosis METHODS: The levels of miR-181c, miR-633, and miR-922 were analyzed in the CSF of 218 patients with MS and 211 patients with other neurologic diseases (OND) by real-time quantitative reverse transcriptase PCR. +other 31575652 hsa-mir-181c Multiple Sclerosis CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that CSF-derived miR-181c and miR-633 distinguish patients with MS from patients with OND. +other 31575652 hsa-mir-633 Multiple Sclerosis CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that CSF-derived miR-181c and miR-633 distinguish patients with MS from patients with OND. +circulation_biomarker_diagnosis_up 31574853 hsa-mir-21 Hypertension Then, to underline the relationship between plasma miR-21 and HT, hypertensive patients were divided into 2 groups: with AOD and without AOD.Sixteen patients with HT had AOD. +other 31574452 hsa-mir-675 Liver Diseases The results showed that the expression of lncRNA H19 and miR-675 was up-regulated in patients with chronic hepatitis B (n=20). The expression of PPARalpha was down-regulated in patients with chronic hepatitis B, and there was a negative correlation between the expression of lncRNA H19 and PPARalpha, or between miR-675 and PPARalpha. +other 31574306 hsa-mir-21 Colorectal Neoplasms AIM: The aim of the study is to evaluate the effect of cigarette smoke extract (CSE) on miR-21, Claudin-1 and E-Cadherin, molecules associated to EMT in colorectal cancer cells. CONCLUSION: These results showed that CSE increasing miR-21, Claudin-1 and E-Cadherin and enhancing the aggressiveness of cancer cells, may concur to colorectal cancer progression. +other 31574295 hsa-mir-181a Anovulation Herein, we identified miR-181a as a central component of activin/Smad3-mediated follicle atresia. +other 31574295 hsa-mir-181a Intestinal Atresia Herein, we identified miR-181a as a central component of activin/Smad3-mediated follicle atresia. +other 31574295 hsa-mir-181a Poisoning miR-181a was strikingly upregulated in porcine atretic follicles, which induced the apoptosis of porcine granulosa cells (GCs) in vitro. +genetics_overexpression_suppress 31574178 hsa-mir-520e Colorectal Neoplasms Overexpression of miR-520e significantly decreased the proliferation, colony formation and invasion of colorectal cancer cells, while inhibition of miR-520e exhibited the opposite effect. +lncRNA target 31573758 hsa-mir-665 Adenocarcinoma of Lung CONCLUSIONS: Circ-TSPAN4 plays a pivotal metastasis-promoting role in LUAD through acting as a sponge for miR-665 and upregulating ZEB1. +other 31573375 hsa-mir-1 Maxillofacial Abnormalities Context: Although bone mesenchymal stem cells (BMSCs) have been used for the treatment of oral and maxillofacial defects, the survival rate and limited proliferation reduces the therapeutic efficiency of BMSC.Objective: The aim of our study is to explore the role of miR-31 in regulating survival, proliferation, and migration of BMSC in vitro.Materials and methods: LPS was used in vitro to induce BMSC damage and then miR-31 was used to incubate with BMSC. +lncRNA target 31573048 hsa-mir-22 Heart Injuries In conclusion, it was demonstrated that RS has been demonstrated to prevent the development of cardiac injury induced by PE via modulating the expression of MALAT1 and further affect miR223p and NLRP3. +lncRNA target 31573048 hsa-mir-22 Pulmonary Embolism In conclusion, it was demonstrated that RS has been demonstrated to prevent the development of cardiac injury induced by PE via modulating the expression of MALAT1 and further affect miR223p and NLRP3. +other 31572691 hsa-mir-199a Tuberculosis, Meningeal Statistically significant differences of 4 miRNAs (miR3p, miR-130a-3p, miR-151a-3p, and miR-199a-5p) were further confirmed in TBM compared with VM and HCs in independent PBMCs sample set (n = 96, P < 0.01). +other 31572691 hsa-mir-126 Tuberculosis, Meningeal Statistically significant differences of 4 miRNAs (miR3p, miR-130a-3p, miR-151a-3p, and miR-199a-5p) were further confirmed in TBM compared with VM and HCs in independent PBMCs sample set (n = 96, P < 0.01). +other 31572691 hsa-mir-130a Tuberculosis, Meningeal Statistically significant differences of 4 miRNAs (miR3p, miR-130a-3p, miR-151a-3p, and miR-199a-5p) were further confirmed in TBM compared with VM and HCs in independent PBMCs sample set (n = 96, P < 0.01). +other 31572691 hsa-mir-151a Tuberculosis, Meningeal Statistically significant differences of 4 miRNAs (miR3p, miR-130a-3p, miR-151a-3p, and miR-199a-5p) were further confirmed in TBM compared with VM and HCs in independent PBMCs sample set (n = 96, P < 0.01). +circulation_biomarker_prognosis_ns 31572685 hsa-mir-375 Prostatic Neoplasms 3p) in liquid biopsies (plasma) of PCa patients with clinically localized disease undergoing curative-intent treatment. +circulation_biomarker_diagnosis_up 31572547 hsa-mir-146a Lupus Erythematosus, Systemic MicroRNA (miR)-146a levels are reduced in peripheral blood mononuclear cells of patients with systemic lupus erythematosus (SLE); however, its function is not well understood. The present study revealed, at least in part, the mechanisms by which miR-146a regulate the inflammatory response in SLE. +transcription factor target 31572545 hsa-mir-192 Diabetic Nephropathies These results suggested that ASI exhibited a therapeutic effect on DN, possibly due to the inhibition of excessive mesangial proliferation and renal fibrosis via the TGF-beta1/Smad/miR-192 signaling pathway. +transcription factor target 31572526 hsa-mir-124 Glioma The effect of miR-124 on the proliferation and differentiation of brain glioma stem cells and Nogo/NgR signaling pathway were investigated. miR-124 may participate in the differentiation of brain glioma stem cells through the Nogo/NgR pathway, which may bring a new direction for the clinical treatment of brain glioma. +circulation_biomarker_diagnosis_down 31572518 hsa-mir-133b Alzheimer Disease A positive correlation between the serum levels of miR-133b and the Mini-Mental State Examination score of AD patients was determined (r=0.8814, P<0.001). +lncRNA target 31572515 hsa-mir-150 Stomach Neoplasms 5p inhibitor attenuated cell viability, induced apoptosis and inhibited gastric cancer cell EMT by targeting SRCIN1. +lncRNA target 31572506 hsa-mir-6852 Carcinoma, Hepatocellular Inhibition of miR-6852 increased proliferation, migration and invasion of HCC cell lines. LncRNA MAFG-AS1 promoted HCC development by dampening miR-6852 function and may thus be a novel target for treating patients with HCC. +lncRNA target 31572505 hsa-mir-183 Reperfusion Injury, Cerebral Ischemia These observations suggest that miR-183 regulates the activation of microglia in rats with cerebral ischemia-reperfusion injury by inhibiting the NF-kappaB signaling pathway. +genetics_overexpression_promote 31572503 hsa-mir-9 Stomach Neoplasms 5p overexpression attenuated GC cell resistance to anti-cancer drugs, which highlighted the potential of miR +other 31572470 hsa-mir-192 Kidney Failure, Chronic MiR-192 and -499 may serve as potential biomarkers for AMI in ESRD. +other 31572470 hsa-mir-122 Myocardial Infarction, Acute MiR-192 and -499 may serve as potential biomarkers for AMI in ESRD. +other 31572470 hsa-mir-499 Myocardial Infarction, Acute Non-significant miR-499 elevation was found in ESRD patients without cardiac disease compared to the control group, while highly significant elevation of miR- 499 was demonstrated in ESRD patients who developed AMI compared to other ESRD patients and the control group (> 100-fold, > 350-fold respectively, p = 0.001). +other 31572470 hsa-mir-499 Kidney Failure, Chronic Non-significant miR-499 elevation was found in ESRD patients without cardiac disease compared to the control group, while highly significant elevation of miR- 499 was demonstrated in ESRD patients who developed AMI compared to other ESRD patients and the control group (> 100-fold, > 350-fold respectively, p = 0.001). +other 31572470 hsa-mir-192 Myocardial Infarction, Acute MiR-192 and -499 may serve as potential biomarkers for AMI in ESRD. +other 31572470 hsa-mir-122 Kidney Failure, Chronic MiR-192 and -499 may serve as potential biomarkers for AMI in ESRD. +transcription factor target 31572460 hsa-mir-124 Urinary Bladder Neoplasms 3p regulates the proliferation and apoptosis of BC cells by suppressing EDNRB expression. +other 31572437 hsa-mir-200b Breast Neoplasms Moreover, miR5p and miR-200b-3p displayed independent prognostic value for disease recurrence in luminal BrC patients after endocrine therapy. +other 31572437 hsa-mir-182 Breast Neoplasms Moreover, miR5p and miR-200b-3p displayed independent prognostic value for disease recurrence in luminal BrC patients after endocrine therapy. +genetics_overexpression_promote 31572380 hsa-mir-142 Granulomatosis with Polyangiitis Conclusion: Overexpression of miR +circulation_biomarker_diagnosis_up 31572127 hsa-mir-204 late onset Parkinson's disease 5p was also observed in the serum and substantia nigra (SN) of 1-methyl +lncRNA target 31572065 hsa-mir-141 Pancreatic Carcinoma In pancreatic cancer tissues and cells, the expression level of NRP-1 was negatively correlated with that of miR-141. CONCLUSIONS: The present results indicate that NRP-1 is negatively regulated by miR-141 and the miR-141/NRP-1 axis may serve as potentially valuable biomarkers and therapeutic targets for pancreatic cancer. +genetics_overexpression_promote 31572010 hsa-mir-376c Thyroid Cancer, Papillary Overexpression of DNM3 abolished the effects of the miR-376c-3p mimic on PTC cells. +lncRNA target 31571997 hsa-mir-506 Retinoblastoma The SIRT1 silencing lessened the miR-506 inhibition on RB cell proliferation and undermined apoptosis. +lncRNA target 31571923 hsa-mir-139 Uterine Cervical Neoplasms 5p was a vital tumor suppressor in CC pathogenesis via targeting TCF4 thereby inhibiting Wnt/beta-catenin signaling. +lncRNA target 31571918 hsa-mir-223 Breast Neoplasms 3p targets and inhibits the expression of ECT2, thus inhibiting the invasion and migration of BC cells, and promoting cell apoptosis. +other 31571916 hsa-mir-122 Glioma Rescue assay further demonstrated that LINC01494/miR5p/CCNG1 signaling cascade plays a critical role in regulating glioma cell proliferation, migration and invasion. +lncRNA target 31571913 hsa-mir-424 Stomach Neoplasms CONCLUSION: Our results implied that miR-424, as a tumor suppressor, could deregulate SMURF1 in DDP-resistant GC cells. +lncRNA target 31571911 hsa-mir-876 Glioma CONCLUSION: Our results conclude that HOXC-AS2/miR5p/ZEB1 constitutes a positive feedback loop to regulate EMT in GBM, providing a potential therapeutic target for glioma. +genetics_knock down_promote 31571907 hsa-mir-200c Cholangiocarcinoma Knockdown of Lnc-ATB in two CCA cell lines HuCCT1 and RBE increased miR-200c levels. +genetics_GWAS 31571904 hsa-mir-125a Stomach Neoplasms An epigenetic mechanism mediates the miR-125a/BRMS1 axis to inhibit the invasion and metastasis of GC cells. +lncRNA target 31571903 hsa-mir-590 Thyroid Cancer, Papillary CONCLUSION: High ZFAS1 expression level was associated with the progression of PTC, and ZFAS1 contributed to PTC progression via miR +other 31571401 hsa-mir-590 Osteoarthritis Collectively, the study revealed that lncRNA PART-1 regulates the apoptosis of chondrocytes in OA by acting as a sponge for miR3p, which subsequently regulates TGFBR2/Smad3 signalling. +genetics_overexpression_promote 31571148 hsa-mir-21 Colorectal Neoplasms NBR2 overexpression downregulated miRNA-21 in colorectal cancer cells, while miRNA-21 overexpression failed to significantly affect NBR2 expression. +genetics_overexpression_promote 31570982 hsa-let-7f-2 Cardiotoxicity Overexpression of lncRNA NEAT1 abolished the increased let-7f +exosome 31570818 hsa-mir-21 Spinal Cord Injuries The exosomes collected from the supernatant of transfected MSCs contained miR-21, which could improve the functional recovery of SCI rats and suppress cell death both in vivo and in vitro via the miR-21/PTEN/PDCD4 signaling pathway. +lncRNA target 31570789 hsa-mir-150 Ovarian Neoplasms Inhibition of miR +transcription factor target 31570702 hsa-mir-532 Colorectal Neoplasms 3p in suppressing CRC progression. +transcription factor target 31570693 hsa-mir-23a Leukemia, Myeloid, Acute Downregulation of miR-23a-5p in leukemic cells leads to upregulation of protective autophagy by targeting TLR2 expression. +lncRNA target 31570691 hsa-mir-5590 Lymphoma, Large B-Cell, Diffuse 3p/ZEB1 positive feedback loop promoted diffuse large B cell lymphoma progression and immune evasion through regulating PD-1/PD-L1 checkpoint, indicating that targeting SNHG14 was a potential approach to improve the efficacy of immunotherapy in DLBCL. +circulation_biomarker_diagnosis_ns 31570669 hsa-mir-155 Hepatitis B, Chronic Conclusion: Compared with PBMC, miR-146a and miR-155 from plasma can better reflect the expression in the liver tissues, suggesting that plasma can be applied in the mechanism research on miR-146a and miR-155 in the liver diseases instead of liver tissues. +circulation_biomarker_diagnosis_ns 31570669 hsa-mir-146a Hepatitis B, Chronic Conclusion: Compared with PBMC, miR-146a and miR-155 from plasma can better reflect the expression in the liver tissues, suggesting that plasma can be applied in the mechanism research on miR-146a and miR-155 in the liver diseases instead of liver tissues. +epigenetics 31570439 hsa-mir-200b Pancreatic Diseases CONCLUSION: Methylation of miR-1247, miR-200a, and miR-200b in bile may be useful for distinguishing PBC from benign diseases. +epigenetics 31570439 hsa-mir-200a Pancreatic Diseases CONCLUSION: Methylation of miR-1247, miR-200a, and miR-200b in bile may be useful for distinguishing PBC from benign diseases. +epigenetics 31570439 hsa-mir-1247 Pancreatic Diseases CONCLUSION: Methylation of miR-1247, miR-200a, and miR-200b in bile may be useful for distinguishing PBC from benign diseases. +genetics_overexpression_promote 31570425 hsa-mir-221 Prostatic Neoplasms While other oncogenic microRNAs showed correlations with prostate cancer cell lines' aggressiveness, miR-221 showed an unusual overexpression in PC3. +other 31570108 hsa-mir-29b Hemorrhagic Fever, Ebola 3p and hsa-miR-27b-5p (down-regulated). +other 31570108 hsa-mir-33a Hemorrhagic Fever, Ebola 3p and hsa-miR-27b-5p (down-regulated). +other 31570108 hsa-mir-3074 Hemorrhagic Fever, Ebola 3p and hsa-miR-27b-5p (down-regulated). +other 31570108 hsa-mir-1307 Hemorrhagic Fever, Ebola 3p and hsa-miR-27b-5p (down-regulated). +other 31570108 hsa-mir-27b Hemorrhagic Fever, Ebola 3p and hsa-miR-27b-5p (down-regulated). +lncRNA target 31570091 hsa-mir-26a Carcinoma, Hepatocellular CONCLUSION: Our study found that miR-26a-5p could inhibit cell proliferation and enhance doxorubicin sensitivity in hepatocellular carcinoma cells by targeting aurora kinase A. +circulation_biomarker_diagnosis_ns 31569928 hsa-mir-155 Breast Neoplasms RESULTS: Serum and tissue miR-155, -320a, and -205 levels in patients with BC are of low diagnostic value as such for differentiation of malignant and non-malignant breast neoplasms. +other 31569791 hsa-mir-92a-1 Cystadenocarcinoma, Serous 5p, miR-200a-3p, and miR-429 were investigated in formalin and matched Bouin's solution-fixed tissues of high grade serous ovarian cancers by means of real-time and droplet digital PCR (ddPCR). +other 31569791 hsa-mir-429 Cystadenocarcinoma, Serous 5p, miR-200a-3p, and miR-429 were investigated in formalin and matched Bouin's solution-fixed tissues of high grade serous ovarian cancers by means of real-time and droplet digital PCR (ddPCR). +other 31569791 hsa-let-7e Cystadenocarcinoma, Serous 5p, miR-200a-3p, and miR-429 were investigated in formalin and matched Bouin's solution-fixed tissues of high grade serous ovarian cancers by means of real-time and droplet digital PCR (ddPCR). +other 31569791 hsa-mir-155 Cystadenocarcinoma, Serous 5p, miR-200a-3p, and miR-429 were investigated in formalin and matched Bouin's solution-fixed tissues of high grade serous ovarian cancers by means of real-time and droplet digital PCR (ddPCR). +other 31569791 hsa-mir-200a Cystadenocarcinoma, Serous 5p, miR-200a-3p, and miR-429 were investigated in formalin and matched Bouin's solution-fixed tissues of high grade serous ovarian cancers by means of real-time and droplet digital PCR (ddPCR). +other 31569791 hsa-mir-423 Cystadenocarcinoma, Serous 5p, miR-200a-3p, and miR-429 were investigated in formalin and matched Bouin's solution-fixed tissues of high grade serous ovarian cancers by means of real-time and droplet digital PCR (ddPCR). +circulation_biomarker_diagnosis_ns 31569706 hsa-mir-150 Pulmonary Disease, Chronic Obstructive 5p in blood of COPD patients was predictive for the development of cancer. +other 31569419 hsa-mir-20b Mouth Neoplasms In silico analysis indicated that miR-126, miR-20b, and miR-106a regulated the highest numbers of differentially expressed transcription factors with respect to human melanoma. +transcription factor target 31569419 hsa-mir-450b Mouth Neoplasms Three oncogenic miRNAs targets (miR-450b, 301a, and 223) from human study also were down-regulated in COM and had a significant negative correlation with their respective miRNA. +other 31569419 hsa-mir-126 Mouth Neoplasms In silico analysis indicated that miR-126, miR-20b, and miR-106a regulated the highest numbers of differentially expressed transcription factors with respect to human melanoma. +other 31569419 hsa-mir-106a Mouth Neoplasms In silico analysis indicated that miR-126, miR-20b, and miR-106a regulated the highest numbers of differentially expressed transcription factors with respect to human melanoma. +genetics_GWAS 31569404 hsa-mir-34a Carcinoma, Transitional Cell Moreover, overexpression of a dominant-negative p53 mutant downregulated miR-34a, but upregulated c-Myc and CD44, in UC cell lines. +lncRNA target 31569377 hsa-mir-221 Intervertebral Disc Degeneration Our hypothesis is that the hostile degenerated IVD microenvironment may be counteracted by regenerative/reparative strategies aimed at maintaining or stimulating high levels of TRPS1 expression through inhibition of one of its negative regulators such as miR-221. +genetics_overexpression_promote 31569377 hsa-mir-221 Substance Abuse, Intravenous Human lumbar IVD tissue samples and IVD primary cells were used to specifically evaluate gene expression and perform functional analysis including the luciferase gene reporter assay, chromatin immunoprecipitation, cell transfection with hTRPS1 overexpression vector and antagomiR-221. +circulation_biomarker_diagnosis_up 31569141 hsa-mir-19b Chronic Pain We evaluated whether peritraumatic miR-19b blood expression levels predicted PTWP and PTSS development in women and men experiencing trauma of motor vehicle collision (n = 179) and in women experiencing sexual assault trauma (n = 74). +lncRNA target 31568800 hsa-mir-1 Atherosclerosis CONCLUSION: Steatotic hepatocyte-derived EVs promote endothelial inflammation and facilitate atherogenesis by miR-1 delivery, KLF4 suppression and NF-kappaB activation. +lncRNA target 31568800 hsa-mir-1 Inflammation CONCLUSION: Steatotic hepatocyte-derived EVs promote endothelial inflammation and facilitate atherogenesis by miR-1 delivery, KLF4 suppression and NF-kappaB activation. +lncRNA target 31568785 hsa-mir-24 Obesity 5p may be a novel therapeutic target against obesity. +lncRNA target 31568700 hsa-mir-155 Neoplasms, Multiple Primary MIR155 host gene can be used as a prognostic marker in multiple cancers, and of great value in predicting the curative effect of immune checkpoint inhibitor therapy owing to it is closely related with immune cells infiltration and immune checkpoint molecules expression. +circulation_biomarker_diagnosis_ns 31568692 hsa-mir-215 Breast Neoplasms In conclusion, we identified a 5-miRNA plasma panel (let-7b-5p, miR +circulation_biomarker_diagnosis_ns 31568692 hsa-mir-210 Breast Neoplasms In conclusion, we identified a 5-miRNA plasma panel (let-7b-5p, miR +circulation_biomarker_diagnosis_ns 31568692 hsa-mir-146b Breast Neoplasms In conclusion, we identified a 5-miRNA plasma panel (let-7b-5p, miR +genetics_overexpression_promote 31568645 hsa-mir-16 Diabetic Nephropathies Taken together, the present study revealed that overexpressed miR +lncRNA target 31567382 hsa-mir-139 Urinary Bladder Neoplasms 5p) is a tumor suppressor in progression of multifarious cancers including BC. +lncRNA target 31567382 hsa-mir-13 Urinary Bladder Neoplasms 5p) is a tumor suppressor in progression of multifarious cancers including BC. +genetics_overexpression_promote 31566720 hsa-mir-218 Coronary Artery Disease Overexpressed miR-218 promoted the proliferation, migration, angiogenesis ability, induced apoptosis, and alleviated the inflammatory injury of CAD-induced CMECs. +genetics_knock down_suppress 31566718 hsa-mir-203a Adenocarcinoma of Lung In addition, we demonstrated that downregulation of miR-203a-3p reversed growth inhibition of LUAD cells caused by FBXL19-AS1 knockdown. Finally, FBXL19-AS1/miR-203a-3p axis was found to associate with baculoviral IAP repeat-containing protein 5.1-A-like (survivin), distal-less homeobox 5, E2F transcription factor 1, and zinc finger E-box binding homeobox 2 to regulate metastasis in LUAD cells. +lncRNA target 31566716 hsa-mir-26b Carcinoma, Non-Small-Cell Lung Besides, miR-26b-5p could negatively regulate LINC00657 or COMMD8 in NSCLC cells. Together, our study illustrated that SP1-stimulated LINC00657 promoted NSCLC progression through targeting miR-26b-5p/COMMD8 axis, offering a novel potential therapeutic target for NSCLC. +lncRNA target 31566711 hsa-mir-184 Carcinoma, Hepatocellular Taken together, the results of this study suggest that as a competing endogenous RNA, LINC00205 may regulate EPHX1 by inhibiting miR-184 in the progression of HCC and that targeting the LINC00205/miR-184/EPHX1 axis may provide a treatment protocol for patients. +lncRNA target 31566128 hsa-mir-144 Osteonecrosis 3p might play an important role in the development of ONFH and might be used as a novel class of therapeutic targets for this disease. +lncRNA target 31565837 hsa-mir-296 Cholangiocarcinoma In conclusion, ZFAS1 might promote cholangiocarcinoma proliferation and metastasis by modulating USF1 via miR5p. +lncRNA target 31565805 hsa-mir-599 Thyroid Cancer, Papillary This study verified that miR-599 promotes apoptosis and represses proliferation, EMT of PTC cells through inactivating the Notch signaling pathway by downregulating Hey2, which has great clinical significance for PTC treatment. +other 31565554 hsa-mir-133a Triple Negative Breast Neoplasms Our series of analyses has shown that five molecules (TERT, TRIML2, PHBP4, mir3p, mir-133a-3p) were significantly associated with the prognosis of TNBC, and there is a prognostic ceRNA sub-network between those molecules. +other 31565554 hsa-mir-1 Triple Negative Breast Neoplasms Our series of analyses has shown that five molecules (TERT, TRIML2, PHBP4, mir3p, mir-133a-3p) were significantly associated with the prognosis of TNBC, and there is a prognostic ceRNA sub-network between those molecules. +other 31565549 hsa-mir-10 Squamous Cell Carcinoma of Head and Neck They and their ceRNA axis genes (particularly TMEM51-AS1-miR-106b-TRAPPC10; RUSC1-AS1-miRSLC39A14) may be potentially important prognostic biomarkers for LSCC. +other 31565549 hsa-mir-16 Squamous Cell Carcinoma of Head and Neck They and their ceRNA axis genes (particularly TMEM51-AS1-miR-106b-TRAPPC10; RUSC1-AS1-miRSLC39A14) may be potentially important prognostic biomarkers for LSCC. +other 31565549 hsa-mir-106b Squamous Cell Carcinoma of Head and Neck They and their ceRNA axis genes (particularly TMEM51-AS1-miR-106b-TRAPPC10; RUSC1-AS1-miRSLC39A14) may be potentially important prognostic biomarkers for LSCC. +other 31565224 hsa-mir-135a Endometriosis The expression levels of miR-135a and miR-135b in endometriosis lesions were decreased compared with the levels in endometrium tissue. However, miR-135a/b expression levels were increased in the secretory phase compared with the proliferative phase in endometriosis lesions. +other 31565224 hsa-mir-135b Endometriosis The expression levels of miR-135a and miR-135b in endometriosis lesions were decreased compared with the levels in endometrium tissue. However, miR-135a/b expression levels were increased in the secretory phase compared with the proliferative phase in endometriosis lesions. +other 31565098 hsa-mir-29 Stomach Neoplasms Bioinformatics analysis predicted that there is a hsa_circ_0006848/hsa_miR5p/RPL6 axis in GC progression. +genetics_knock down_suppress 31565080 hsa-mir-200 Colorectal Neoplasms Knockdown of the miR-200 family in the HT-29 colon cancer cell line increased KRAS expression but decreased signaling in the MAPK/ERK signaling pathway through reduced ERK phosphorylation. +genetics_overexpression_promote 31564967 hsa-mir-361 Osteosarcoma Mechanistically, cell growth and metastasis-related target genes of MIR-361 including VEGF, FOXM1 and Twist were de-repressed in OS cells by MIR31HG overexpression, leading to upregulated BCL2, CCND1 and epithelial-mesenchymal transition (EMT) phenotype. +other 31564967 hsa-mir-1 Osteosarcoma MicroRNA-31 (miR-31)-host gene LncRNA (MIR31HG) have been recognized as an oncogene in many cancers, but not in osteosarcoma (OS). +circulation_biomarker_diagnosis_up 31564936 hsa-mir-126 Diabetes Mellitus PURPOSE: Our study aims to explore the effect of NPWT on the expression of miR-126 in the wound tissue and plasma of diabetic rat models and the association between circulating miR-126 and two quantitative indexes of angiogenesis. +genetics_overexpression_suppress 31564916 hsa-mir-6840 Squamous Cell Carcinoma of Head and Neck Overexpression of miR3p or downregulation of PLXNB1 can abrogate ZEB2-AS1-mediated LSCC malignant development. +genetics_knock down_suppress 31564905 hsa-mir-21 Pancreatic Carcinoma CONCLUSION: Knockdown miR-21 increased the expression of VHL, and thus modulated the HIF-1alpha/VEGF pathway and the expression of MMP-2 and MMP-9, which led to the inhibition of the proliferation, migration and invasion of pancreatic cancer cells. +lncRNA target 31564904 hsa-mir-765 Osteosarcoma High expression of miR-765 may benefit OS patient survival, making it a viable target for reversing cisplatin-induced resistance in OS patients. +lncRNA target 31564901 hsa-mir-122 Glioma 5p-SATB1-c-Myc feedback loop and provides a potential therapeutic target for glioma treatment. +lncRNA target 31564894 hsa-mir-424 Neuroendocrine Tumors CONCLUSION: In conclusion, the fundamental findings of the present study suggested that the functional suppression of XIST downregulated bFGF to inhibit the development of PitNET by increasing miR +transcription factor target 31564413 hsa-mir-207 Diabetic Cardiomyopathies In conclusion, miR-207 inhibited autophagy and promoted apoptosis of cardiomyocytes by directly targeting LAMP2, which participated in the development of type 2 diabetic cardiomyopathy. +other 31564221 hsa-mir-21 Carcinoma, Renal Cell Interestingly, entropy and miR5p show promising correlation in clear cell renal cell carcinoma opening to a radiogenomic strategy to improve clear cell renal cell carcinoma management. +lncRNA target 31564215 hsa-mir-122 Colonic Neoplasms The top 3 upregulated microRNAs (miR-10, miR-199, and miR-122) in colon cancer cells were further validated in tissues of clinical patients via reverse transcription-quantitative polymerase chain reaction. +lncRNA target 31564215 hsa-mir-10 Colonic Neoplasms The top 3 upregulated microRNAs (miR-10, miR-199, and miR-122) in colon cancer cells were further validated in tissues of clinical patients via reverse transcription-quantitative polymerase chain reaction. +lncRNA target 31564215 hsa-mir-199 Colonic Neoplasms The top 3 upregulated microRNAs (miR-10, miR-199, and miR-122) in colon cancer cells were further validated in tissues of clinical patients via reverse transcription-quantitative polymerase chain reaction. +lncRNA target 31563901 hsa-mir-296 Pancreatic Carcinoma Bioinformative target gene analysis and transfection experiments with miRNA mimics showed that Bcl2-related ovarian killer (BOK), a pro-apoptotic gene, is a target for miR296-5p in pancreatic cancer cells; transfection of miR +lncRNA target 31563323 hsa-let-7c Carcinoma, Hepatocellular Taken together, SNHG6 promotes HCC cell proliferation via competitively binding let-7c-5p in hepatocellular carcinoma. +transcription factor target 31563103 hsa-mir-181a Cognition Disorders Our findings indicate that the up-regulation of Grp78 mediated by inhibition of miR-181a-5p is a possible mechanism resulting in ER stress and cognitive impairment in pups following prenatal MCLR exposure. +lncRNA target 31562981 hsa-mir-24 Atrial Fibrillation CONCLUSIONS: LINC00472 could regulate the progression of AF via modulating the LINC00472/miR-24/JP2/RyR2 signaling pathway. +lncRNA target 31562977 hsa-mir-195 Carcinoma, Hepatocellular Subsequently, in vivo experiments were employed and it was manifested that LINC00473 was able to promote HCC tumor growth via acting as a ceRNA to inhibit miR-195. Taken all these together, our study revealed the significance of LINC00473/miR-195/HMGA2 signaling axis for the first time in HCC progression. +exosome 31562861 hsa-mir-1273f Carcinoma, Hepatocellular When we analyzed these exosomes, we found that miR-1273f were present at higher levels under hypoxic conditions, and we determined that this miRNA was responsible for directly replicating the effects of hypoxic exosomes within HCC cells, in addition to activating the Wnt/beta-catenin signaling. These results, thus, provide evidence that hypoxic conditions can lead HCC cells to express increased exosomes that facilitate miR-1273f expression in normoxic cells, thereby enhancing their malignant phenotype at least in part by targeting LHX6 for downregulation. +transcription factor target 31562809 hsa-mir-27a Obesity Therefore, miR-27a is a novel target for the treatment of IR in obesity and diabetes. +lncRNA target 31562809 hsa-mir-27a Insulin Resistance Therefore, miR-27a is a novel target for the treatment of IR in obesity and diabetes. +transcription factor target 31562809 hsa-mir-27a Diabetes Mellitus Therefore, miR-27a is a novel target for the treatment of IR in obesity and diabetes. +transcription factor target 31562641 hsa-mir-127 Prostatic Neoplasms 3p could function as a promising therapeutic target against bone metastasis. +circulation_biomarker_diagnosis_up 31562613 hsa-mir-494 Pancreatic Carcinoma 3p-silenced MYC in cytoplasm and upregulating MYC-activated KRAS in nucleus, unveiling LINC01420 as a latent therapeutic strategy for PC patients. +circulation_biomarker_diagnosis_down 31562552 hsa-mir-424 Aortic Valve Disease Furthermore, a significant down-regulation of the circulating miR +circulation_biomarker_diagnosis_ns 31562552 hsa-mir-3688 Aortic Valve Disease The purpose of this study was to assess the biological role as well as the circulating expression of two miRs (miR +transcription factor target 31562534 hsa-mir-29c Gallbladder Neoplasms CONCLUSIONS: Our findings indicate that miR2-3p and miR-29c-3p play crucial roles in the pathogenesis and worse prognosis of GBCs, which may serve as prognosis biomarkers and promise potential therapeutic targets in the future. +transcription factor target 31562534 hsa-mir-7-2 Gallbladder Neoplasms CONCLUSIONS: Our findings indicate that miR2-3p and miR-29c-3p play crucial roles in the pathogenesis and worse prognosis of GBCs, which may serve as prognosis biomarkers and promise potential therapeutic targets in the future. +other 31562386 hsa-mir-133a Pulmonary Arterial Hypertension ES administration relieved the deregulation of miR-133a, MYOSLID, SRF, and CTGF in PAH rats. ES treatment upregulates miR-133a expression and reduces the incidence of PAH and vascular remodeling. +other 31562301 hsa-mir-574 Stomach Neoplasms the arm-imbalance of miR-574 is in turn involved and further promotes gastric cancer progression +tissue_expression_up 31562019 hsa-mir-188 Urinary Bladder Neoplasms miR-188-5p and miR-141-3p were highly expressed in BC tissues and cells +tissue_expression_up 31562019 hsa-mir-141 Urinary Bladder Neoplasms miR-188-5p and miR-141-3p were highly expressed in BC tissues and cells +tissue_expression_up 31561740 hsa-mir-122 Carcinoma, Hepatocellular Sp1 bound to the miR-122 promoter at two different sites. Interestingly, either inhibition or overexpression of Sp1 could decrease the miR-122 promoter activity and the cellular miR-122 level in hepatoma cells +lncRNA target 31561732 hsa-mir-637 Glioma LINC00473 could act as a ceRNA of miR-637 to promote glioma progression through regulating CDK6 expression +tissue_expression_down 31561723 hsa-mir-194 Carcinoma, Hepatocellular hypoxia was responsible for the down-expression of miR-3194-3p in HCC +transcription factor target 31561595 hsa-mir-34a Glioblastoma Notably, LCCmediated anti-GBM/GSC activities were associated with the re-expression of tumor suppressor miR-34a and reversal of TMZ-resistance, in vitro and in vivo. +genetics_knock down_promote 31561126 hsa-mir-150 Carcinoma, Non-Small-Cell Lung 5p will recover NSCLC cell proliferation and metastasis after a knockdown of circARHGAP10. +transcription factor target 31561124 hsa-mir-149 Obesity These findings provided direct evidence of the anti-obese and anti-diabetic effect of PRDM16 in the obese background for the first time and identified that miR3p could serve as a therapeutic target to protect against diet-induced obesity and metabolic dysfunctions. +circulation_biomarker_diagnosis_ns 31560760 hsa-mir-5189 Thyroid Cancer, Papillary miR-5189-3p had the most optimal performance for diagnosis between PTC and NG +circulation_biomarker_prognosis_ns 31560680 hsa-mir-217 Colorectal Neoplasms miRNA-216a, miRNA-887, miRNA-376b, and miRNA-891a were used to build the prediction formula associated with OS, while miR-1343, miR-149, miR-181a-1, miR-217, miR-3130-1, miR-378a, miR-542, miR-6716, miR-7-3, miR-7702, miR-677, and miR-891a were obtained to construct the formula related to RFS +circulation_biomarker_prognosis_ns 31560680 hsa-mir-376b Colorectal Neoplasms miRNA-216a, miRNA-887, miRNA-376b, and miRNA-891a were used to build the prediction formula associated with OS, while miR-1343, miR-149, miR-181a-1, miR-217, miR-3130-1, miR-378a, miR-542, miR-6716, miR-7-3, miR-7702, miR-677, and miR-891a were obtained to construct the formula related to RFS +circulation_biomarker_prognosis_ns 31560680 hsa-mir-887 Colorectal Neoplasms miRNA-216a, miRNA-887, miRNA-376b, and miRNA-891a were used to build the prediction formula associated with OS, while miR-1343, miR-149, miR-181a-1, miR-217, miR-3130-1, miR-378a, miR-542, miR-6716, miR-7-3, miR-7702, miR-677, and miR-891a were obtained to construct the formula related to RFS +circulation_biomarker_prognosis_ns 31560680 hsa-mir-7 Colorectal Neoplasms miRNA-216a, miRNA-887, miRNA-376b, and miRNA-891a were used to build the prediction formula associated with OS, while miR-1343, miR-149, miR-181a-1, miR-217, miR-3130-1, miR-378a, miR-542, miR-6716, miR-7-3, miR-7702, miR-677, and miR-891a were obtained to construct the formula related to RFS +circulation_biomarker_prognosis_ns 31560680 hsa-mir-149 Colorectal Neoplasms miRNA-216a, miRNA-887, miRNA-376b, and miRNA-891a were used to build the prediction formula associated with OS, while miR-1343, miR-149, miR-181a-1, miR-217, miR-3130-1, miR-378a, miR-542, miR-6716, miR-7-3, miR-7702, miR-677, and miR-891a were obtained to construct the formula related to RFS +circulation_biomarker_prognosis_ns 31560680 hsa-mir-216a Colorectal Neoplasms miRNA-216a, miRNA-887, miRNA-376b, and miRNA-891a were used to build the prediction formula associated with OS, while miR-1343, miR-149, miR-181a-1, miR-217, miR-3130-1, miR-378a, miR-542, miR-6716, miR-7-3, miR-7702, miR-677, and miR-891a were obtained to construct the formula related to RFS +circulation_biomarker_prognosis_ns 31560680 hsa-mir-542 Colorectal Neoplasms miRNA-216a, miRNA-887, miRNA-376b, and miRNA-891a were used to build the prediction formula associated with OS, while miR-1343, miR-149, miR-181a-1, miR-217, miR-3130-1, miR-378a, miR-542, miR-6716, miR-7-3, miR-7702, miR-677, and miR-891a were obtained to construct the formula related to RFS +circulation_biomarker_prognosis_ns 31560680 hsa-mir-1343 Colorectal Neoplasms miRNA-216a, miRNA-887, miRNA-376b, and miRNA-891a were used to build the prediction formula associated with OS, while miR-1343, miR-149, miR-181a-1, miR-217, miR-3130-1, miR-378a, miR-542, miR-6716, miR-7-3, miR-7702, miR-677, and miR-891a were obtained to construct the formula related to RFS +circulation_biomarker_prognosis_ns 31560680 hsa-mir-6716 Colorectal Neoplasms miRNA-216a, miRNA-887, miRNA-376b, and miRNA-891a were used to build the prediction formula associated with OS, while miR-1343, miR-149, miR-181a-1, miR-217, miR-3130-1, miR-378a, miR-542, miR-6716, miR-7-3, miR-7702, miR-677, and miR-891a were obtained to construct the formula related to RFS +circulation_biomarker_prognosis_ns 31560680 hsa-mir-891a Colorectal Neoplasms miRNA-216a, miRNA-887, miRNA-376b, and miRNA-891a were used to build the prediction formula associated with OS, while miR-1343, miR-149, miR-181a-1, miR-217, miR-3130-1, miR-378a, miR-542, miR-6716, miR-7-3, miR-7702, miR-677, and miR-891a were obtained to construct the formula related to RFS +circulation_biomarker_prognosis_ns 31560680 hsa-mir-677 Colorectal Neoplasms miRNA-216a, miRNA-887, miRNA-376b, and miRNA-891a were used to build the prediction formula associated with OS, while miR-1343, miR-149, miR-181a-1, miR-217, miR-3130-1, miR-378a, miR-542, miR-6716, miR-7-3, miR-7702, miR-677, and miR-891a were obtained to construct the formula related to RFS +circulation_biomarker_prognosis_ns 31560680 hsa-mir-181a-1 Colorectal Neoplasms miRNA-216a, miRNA-887, miRNA-376b, and miRNA-891a were used to build the prediction formula associated with OS, while miR-1343, miR-149, miR-181a-1, miR-217, miR-3130-1, miR-378a, miR-542, miR-6716, miR-7-3, miR-7702, miR-677, and miR-891a were obtained to construct the formula related to RFS +circulation_biomarker_prognosis_ns 31560680 hsa-mir-7702 Colorectal Neoplasms miRNA-216a, miRNA-887, miRNA-376b, and miRNA-891a were used to build the prediction formula associated with OS, while miR-1343, miR-149, miR-181a-1, miR-217, miR-3130-1, miR-378a, miR-542, miR-6716, miR-7-3, miR-7702, miR-677, and miR-891a were obtained to construct the formula related to RFS +circulation_biomarker_prognosis_ns 31560680 hsa-mir-378a Colorectal Neoplasms miRNA-216a, miRNA-887, miRNA-376b, and miRNA-891a were used to build the prediction formula associated with OS, while miR-1343, miR-149, miR-181a-1, miR-217, miR-3130-1, miR-378a, miR-542, miR-6716, miR-7-3, miR-7702, miR-677, and miR-891a were obtained to construct the formula related to RFS +circulation_biomarker_prognosis_ns 31560680 hsa-mir-3130-1 Colorectal Neoplasms miRNA-216a, miRNA-887, miRNA-376b, and miRNA-891a were used to build the prediction formula associated with OS, while miR-1343, miR-149, miR-181a-1, miR-217, miR-3130-1, miR-378a, miR-542, miR-6716, miR-7-3, miR-7702, miR-677, and miR-891a were obtained to construct the formula related to RFS +other 31560641 hsa-mir-146a Liver Cirrhosis miR-146a-5p may negatively regulate the PTPRA-SRC signaling to inhibit expression of fibrosis-related markers in irradiated and TGF-beta1-stimulated LX2 cells. +lncRNA target 31559872 hsa-mir-7 Heart Septal Defects, Ventricular UA and SM are essential VSD-associated metabolic biomarkers and MEG3/miR-7-5p/EGFR axis is critical to the regulation of autophagy in cardiomyocytes. +target gene 31559693 hsa-mir-101 Stomach Neoplasms these findings provide a model for the role of miR-101-3p-IRF2BP2-CTGF signalling axis in GC +target gene 31559672 hsa-mir-451a Thyroid Cancer, Papillary miR-451a could inhibit thyroid cancer progression by targeting proteasome subunit beta type-8 +other 31559550 hsa-mir-21 Carcinoma, Hepatocellular NG-R1 exerted anti-hepatoma activity through inactivation of the PI3K/Akt pathway by downregulating miR-21, contributing to further understanding of the anti-tumor activities of NG-R1 in HCC. +other 31559537 hsa-mir-1 Diabetes Mellitus, Type 2 5p, and miR-133a-3p, compared with controls. +other 31559537 hsa-mir-34a Diabetes Mellitus, Type 2 5p, and miR-133a-3p, compared with controls. +other 31559537 hsa-mir-24 Diabetes Mellitus, Type 2 5p, and miR-133a-3p, compared with controls. +other 31559537 hsa-let-7b Diabetes Mellitus, Type 2 5p, and miR-133a-3p, compared with controls. +other 31559537 hsa-mir-133a Diabetes Mellitus, Type 2 5p, and miR-133a-3p, compared with controls. +other 31559405 hsa-mir-21 Colorectal Neoplasms It can be further applied for intracellular miR-21 imaging in CD44-positive colorectal cancer cells. +lncRNA target 31558975 hsa-mir-31 Stomach Neoplasms Furthermore, upregulation of MSI1 weakened the inhibitory effect of miR-331 in GC. +lncRNA target 31558874 hsa-mir-1273a Colonic Neoplasms overexpression of miR-1273a abrogated the oncogenic function of circPIP5K1A in colon cancers +lncRNA target 31558873 hsa-mir-372 Carcinoma, Hepatocellular the HULC/miR-372-3p/Rab11a axis in HCC +circulation_biomarker_diagnosis_ns 31558801 hsa-mir-92a Lung Neoplasms Elevated levels of circulating miR-92a are found in the sera of lung cancer patients +other 31558773 hsa-mir-21 Keloid miR-21-5p could be a new therapeutic target, to replace EB irradiation, and control keloid relapse. +lncRNA target 31558707 hsa-mir-205 Glioblastoma the linc00645/miR-205-3p/ZEB1 signaling axis as a key player in EMT of glioma cells triggered by TGF-beta. +target gene 31558704 hsa-mir-17 Carcinoma, Hepatocellular downregulation on Smad3 expression was consistent with high level of miR-17 in HCC tissues of patients when compared with around normal liver tissues. +tissue_expression_down 31558368 hsa-mir-21 Colonic Neoplasms MiR-21 expression levels in colon cancer cells transfected with pmiRZip21 in vivo or in vitro were decreased (P<0.05). +tissue_expression_down 31558304 hsa-mir-183 Stomach Neoplasms miR-183-5p was down-regulated in GC tissues and cell lines. +circulation_biomarker_prognosis_up 31558294 hsa-mir-200c Neoplasms high level of miR-200b and miR-200c was associated with poor patients' survival. +circulation_biomarker_prognosis_ns 31558294 hsa-mir-141 Pancreatic Neoplasms Expression of miR-141 was found to be associated with favorable patients' survival in pancreatic cancer (HR=0.275, 95% CI: 0.104-0.727, p=0.009) +circulation_biomarker_prognosis_ns 31558294 hsa-mir-429 Liver Neoplasms expression of miR-200a and miR-429 was associated with survival of breast cancer and liver cancer, respectively. +circulation_biomarker_prognosis_ns 31558294 hsa-mir-200a Breast Neoplasms expression of miR-200a and miR-429 was associated with survival of breast cancer and liver cancer, respectively. +circulation_biomarker_prognosis_up 31558294 hsa-mir-200b Neoplasms high level of miR-200b and miR-200c was associated with poor patients' survival. +genetics_overexpression_suppress 31558184 hsa-mir-122 Carcinoma, Hepatocellular miR-122 was reduced in hepatocarcinoma tissues compared to the paracarcinoma tissues, which was relatively low or high in hepatocarcinoma cell line SMMC7721 or Hep3B, and overexpressed miR-122 inhibited proliferation, migration, and invasion in hepatocarcinoma cells. +lncRNA target 31558183 hsa-mir-195 Esophageal Squamous Cell Carcinoma FOXD2-AS1/miR-195/Akt/mTOR axis plays a crucial role in resistance to cisplatin in ESCC cells +target gene 31557499 hsa-mir-203a Polycystic Ovary Syndrome MALAT1 reduction was identified in GCs, which may contribute to the pathophysiological processes of PCOS by regulating TGFbeta signaling through sponging miR-125b and miR-203a. +target gene 31557499 hsa-mir-125b Polycystic Ovary Syndrome MALAT1 reduction was identified in GCs, which may contribute to the pathophysiological processes of PCOS by regulating TGFbeta signaling through sponging miR-125b and miR-203a. +target gene 31557418 hsa-mir-590 Glomerulonephritis, IGA HMGB2, the target gene of hsa-miR-590-3p, was identified to correlate with the severity of IgAN +target gene 31557403 hsa-mir-27a Uterine Cervical Neoplasms the up-regulation of INPP1 by miR-27a contributes to tumorigenic activities and may provide a potential biomarker for CC. +lncRNA target 31557398 hsa-mir-145 Pulmonary Disease, Chronic Obstructive TUG1 promoted the expression of dual-specificity phosphatase 6 (DUSP6) by sponging miR-145-5p +genetics_knock down_promote 31557368 hsa-mir-130a Aicardi-Goutieres syndrome 5 CONCLUSIONS: The results indicated that miR-130a promotes osteoblastic differentiation of BMSC by negatively regulating Smurf2 expression and suppresses adipogenic differentiation of BMSC by targeting the PPARgamma, and supply a new target for clinical therapy of age-related bone loss. +lncRNA target 31557058 hsa-mir-106a Nasopharyngeal Carcinoma SMAD5-AS1 was highly expressed and miR-106a-5p was poorly expressed in NPC tissues and cell lines. +circulation_biomarker_diagnosis_ns 31556888 hsa-mir-150 Premature Birth detection of endogenous concentrations of miR-150-5p, a recently identified predictive blood biomarker for preterm birth. +genetics_GWAS 31556863 hsa-mir-605 Breast Neoplasms The results indicated an increased risk for breast cancer susceptibility for miR-605 rs2043556 in the Iranian population. +transcription factor target 31556851 hsa-mir-155 Nervous System Diseases CONCLUSION: We showed the significant role of blocking miR-155 signal in improving the neurological function in CA rats likely via inhibition of signal pathways of neuroinflammation and oxidative stress, suggesting that miR-155 may be a target in preventing and/or alleviating development of the impaired neurological functions during CA-evoked global cerebral ischemia. +transcription factor target 31556851 hsa-mir-155 Brain Ischemia CONCLUSION: We showed the significant role of blocking miR-155 signal in improving the neurological function in CA rats likely via inhibition of signal pathways of neuroinflammation and oxidative stress, suggesting that miR-155 may be a target in preventing and/or alleviating development of the impaired neurological functions during CA-evoked global cerebral ischemia. +transcription factor target 31556851 hsa-mir-155 Parkinson Disease CONCLUSION: We showed the significant role of blocking miR-155 signal in improving the neurological function in CA rats likely via inhibition of signal pathways of neuroinflammation and oxidative stress, suggesting that miR-155 may be a target in preventing and/or alleviating development of the impaired neurological functions during CA-evoked global cerebral ischemia. +other 31556848 hsa-mir-17 Brain Injuries Candidate miRNAs, such as miR-17, miR-128 or miR-15b, significantly discriminated TBI from different PBI exposure patterns, and 5-tofold changes in gene expression were observed among the groups. +other 31556848 hsa-mir-128 Familial encephalopathy with neuroserpin inclusion bodies Candidate miRNAs, such as miR-17, miR-128 or miR-15b, significantly discriminated TBI from different PBI exposure patterns, and 5-tofold changes in gene expression were observed among the groups. +other 31556848 hsa-mir-128 Brain Injuries Candidate miRNAs, such as miR-17, miR-128 or miR-15b, significantly discriminated TBI from different PBI exposure patterns, and 5-tofold changes in gene expression were observed among the groups. +other 31556848 hsa-mir-17 Familial encephalopathy with neuroserpin inclusion bodies Candidate miRNAs, such as miR-17, miR-128 or miR-15b, significantly discriminated TBI from different PBI exposure patterns, and 5-tofold changes in gene expression were observed among the groups. +other 31556848 hsa-mir-15b Brain Injuries Candidate miRNAs, such as miR-17, miR-128 or miR-15b, significantly discriminated TBI from different PBI exposure patterns, and 5-tofold changes in gene expression were observed among the groups. +other 31556848 hsa-mir-15b Familial encephalopathy with neuroserpin inclusion bodies Candidate miRNAs, such as miR-17, miR-128 or miR-15b, significantly discriminated TBI from different PBI exposure patterns, and 5-tofold changes in gene expression were observed among the groups. +circulation_biomarker_diagnosis_ns 31556571 hsa-mir-107 Alzheimer Disease Changed levels of plasma apoE, miR-107 and miR-650 may be a marker of the neurodegenerative process in the course of AD +circulation_biomarker_diagnosis_ns 31556571 hsa-mir-650 Alzheimer Disease Changed levels of plasma apoE, miR-107 and miR-650 may be a marker of the neurodegenerative process in the course of AD +tissue_expression_up 31556476 hsa-mir-4516 Essential Hypertension miRNA 4516 and norepinephrine levels were significantly higher in the HT group (P < .005 for both), while miRNA 145 levels were significantly lower (<.05). miRNA 4516 up-regulation (P < .05) and miRNA 145 down-regulation (P < .05) were identified as independent predictors of HT. +tissue_expression_down 31556476 hsa-mir-145 Essential Hypertension miRNA 4516 and norepinephrine levels were significantly higher in the HT group (P < .005 for both), while miRNA 145 levels were significantly lower (<.05). miRNA 4516 up-regulation (P < .05) and miRNA 145 down-regulation (P < .05) were identified as independent predictors of HT. +lncRNA target 31556327 hsa-let-7 Nasopharyngeal Carcinoma H19 competitively sponged let-7 genes and therefore up-regulated HRAS, which consequently contributed to its oncogenic activity in nasopharyngeal carcinomas. +other 31556305 hsa-mir-766 Brain Injuries We further provided the possible mechanism that Gm11974/miR3p/NR3C2 axis plays important role in cerebral I/R injury. +other 31556305 hsa-mir-766 Brain Ischemia We further provided the possible mechanism that Gm11974/miR3p/NR3C2 axis plays important role in cerebral I/R injury. +other 31556264 hsa-mir-155 Pulmonary Fibrosis microRNA-155 (miR-155), the expression of which has been related to bleomycin-induced idiopathic pulmonary fibrosis, has been involved in TGF-beta induced epithelial-mesenchymal transition. +transcription factor target 31555879 hsa-mir-146a Diabetes Mellitus Notably, iAs exposure caused a significant decrease in the expression of Camk2a, a calcium-dependent protein kinase that regulates insulin secretion, has been implicated in type 2 diabetes, and is a likely target of miR-146a. +other 31555878 hsa-mir-16 Pulmonary Disease, Chronic Obstructive Likewise, miR16, miR21, miR146, and miR222 were identified to be differentially expressed in smokers and exhibit potential as biomarkers for determining susceptibility to COPD. +other 31555878 hsa-mir-146 Pulmonary Disease, Chronic Obstructive Likewise, miR16, miR21, miR146, and miR222 were identified to be differentially expressed in smokers and exhibit potential as biomarkers for determining susceptibility to COPD. +other 31555878 hsa-mir-21 Pulmonary Disease, Chronic Obstructive Likewise, miR16, miR21, miR146, and miR222 were identified to be differentially expressed in smokers and exhibit potential as biomarkers for determining susceptibility to COPD. +other 31555878 hsa-mir-222 Pulmonary Disease, Chronic Obstructive Likewise, miR16, miR21, miR146, and miR222 were identified to be differentially expressed in smokers and exhibit potential as biomarkers for determining susceptibility to COPD. +transcription factor target 31555385 hsa-mir-370 Coronary Artery Disease Therefore, miR-370 may be a new therapeutic target for ischemic heart disease. +other 31555385 hsa-mir-370 Heart Diseases The aim of the present study was to investigate the effect of miR-370 on oxidative stress and apoptosis of cardiac myocytes in ischemic H9C2 cells induced by hydrogen peroxide (H(2)O(2)). +lncRNA target 31555365 hsa-mir-210 Carcinoma, Non-Small-Cell Lung 3p has the potential to become a novel therapeutic target for the treatment of NSCLC. +other 31555359 hsa-mir-21 Parkinson Disease The present study aimed to investigate the role of miR-21 in the development of PD. +transcription factor target 31555358 hsa-mir-34a Colorectal Neoplasms The present study demonstrated that miR-34a was deregulated in a highly invasive CRC cell lines, and that it may attenuate the migratory, invasive and proliferative capabilities of CRC cells by enhancing the expression of EGR1 and inhibiting that of vimentin. +transcription factor target 31555352 hsa-mir-599 Thyroid Carcinoma, Anaplastic In conclusion, the present study revealed that miR-599 inhibited ATC cell growth and metastasis via activation of TIA1. +lncRNA target 31555350 hsa-mir-135a Osteoporosis Taken together, these results suggest that miR-135a-5p may serve a role in osteoporosis progression by regulating osteogenic differentiation via RUNX2. +other 31555200 hsa-mir-3123 Embolic Stroke 5p, 0.687 (95% CI 0.543-0.830) for miR-206, and 0.661 (95% CI 0.512-0.810) for miR-3123. +other 31555200 hsa-mir-21 Embolic Stroke 5p, 0.687 (95% CI 0.543-0.830) for miR-206, and 0.661 (95% CI 0.512-0.810) for miR-3123. +other 31555200 hsa-mir-206 Embolic Stroke 5p, 0.687 (95% CI 0.543-0.830) for miR-206, and 0.661 (95% CI 0.512-0.810) for miR-3123. +genetics_knock down_promote 31555130 hsa-mir-532 Squamous Cell Carcinoma of Head and Neck 3p suppressed TSCC cell proliferation, migration, invasion, and promoted apoptosis in vitro, whilst the knockdown of miR +genetics_GWAS 31555064 hsa-mir-196a Liver Injury In multivariate logistic regression, taking nevirapine, 196aCT genotype had an independent risk factor for hepatotoxicity severity (OR=5.98, P=0.005; OR=2.38, P=0.05).Conclusion: In conclusion, miR196aC/T polymorphism and combined genotypes GCT and CCC may facilitate the risk for acquisition of hepatotoxicity and its severity. +genetics_GWAS 31555064 hsa-mir-196 Liver Injury In multivariate logistic regression, taking nevirapine, 196aCT genotype had an independent risk factor for hepatotoxicity severity (OR=5.98, P=0.005; OR=2.38, P=0.05).Conclusion: In conclusion, miR196aC/T polymorphism and combined genotypes GCT and CCC may facilitate the risk for acquisition of hepatotoxicity and its severity. +lncRNA target 31554487 hsa-mir-21 Carcinoma, Hepatocellular CONCLUSION: The upregulated microRNA-21 might participate in the proliferation and migration in cells of hepatocellular carcinoma via suppression of smad family member 7. +other 31554377 hsa-mir-145 Carcinoma, Non-Small-Cell Lung Therefore, miRNA-145 replacement therapy can become a new therapeutic strategy in lung cancer. +circulation_biomarker_diagnosis_ns 31554373 hsa-mir-34a Breast Neoplasms Our data suggest that circulating miR-34a and miR-125b expression levels could be promising highly accurate non-invasive biomarkers in diagnosing BCs. +circulation_biomarker_diagnosis_ns 31554373 hsa-mir-125b Breast Neoplasms Our data suggest that circulating miR-34a and miR-125b expression levels could be promising highly accurate non-invasive biomarkers in diagnosing BCs. +circulation_biomarker_diagnosis_up 31554369 hsa-mir-215 Carcinoma, Hepatocellular Conclusions: Plasma level of miR-215 may be a promising biomarker in HCC diagnosis. +lncRNA target 31553952 hsa-mir-335 Carcinoma, Non-Small-Cell Lung Taken together, knock-down of LncRNA-XIST inhibited NSCLC progression by triggering miR-335/SOD2/ROS signal pathway mediated pyroptotic cell death. +circulation_biomarker_diagnosis_up 31553714 hsa-mir-744 Carcinoma, Hepatocellular RESULTS MiR-744 is downregulated in HCC tissues and cell lines as well as in exosomes derived from patient serum and HepG2 cells. +circulation_biomarker_diagnosis_ns 31553692 hsa-mir-371 Neoplasms, Germ Cell and Embryonal Developing a Highly Specific Biomarker for Germ Cell Malignancies: Plasma miR371 Expression Across the Germ Cell Malignancy Spectrum. PURPOSE Our objective was to evaluate operating characteristics, particularly specificity and positive predictive value (PPV), by mapping plasma miR371 expression to actual clinical events in patients with a history of germ cell tumor. +genetics_overexpression_promote 31553627 hsa-mir-29b Pulmonary Arterial Hypertension Additionally, overexpression of miR-29b in normal PASMC decreased large-conductance Ca(2+)-activated K(+) (BK(Ca)) channel currents and downregulated BK(Ca) channel beta1 subunit (BK(Ca)beta1 or KCNMB1) expression, while inhibition of miR-29b in IPAH-PASMC increased BK(Ca) channel activity and BK(Ca)beta1 levels. +lncRNA target 31553600 hsa-mir-22 Diabetes Mellitus, Type 2 Recently, we discovered that DNAs targeting microRNA +lncRNA target 31553600 hsa-mir-22 Hyperlipidemias Recently, we discovered that DNAs targeting microRNA +lncRNA target 31553600 hsa-mir-22 Obesity Recently, we discovered that DNAs targeting microRNA +lncRNA target 31553600 hsa-mir-22 Metabolic Diseases Recently, we discovered that DNAs targeting microRNA +lncRNA target 31553078 hsa-mir-145 Aortic Aneurysm, Abdominal Taken together, miR-145 and miR-30c-2*, downregulated in AAA, could potentially affect AAA, and miR-145 might target RAC2, whereas miR-30c-2* might target PIK3CD, IL1B and RAC2. +lncRNA target 31552681 hsa-mir-20a Periodontal Diseases CONCLUSION: MALAT1 enhances inflammatory cytokine production through sponging miR-20a and releasing TLR4, indicating a regulatory role of MALAT1 in periodontal inflammation. +other 31552489 hsa-mir-146b Urinary Bladder Neoplasms In urinary EVs, a different expression was verified for miR-146b-5p (P = 0.004) and miR5p (P = 0.036), which exhibited significantly higher expression in urinary EVs from patients with MIBC. +other 31552489 hsa-mir-155 Urinary Bladder Neoplasms In urinary EVs, a different expression was verified for miR-146b-5p (P = 0.004) and miR5p (P = 0.036), which exhibited significantly higher expression in urinary EVs from patients with MIBC. +other 31551809 hsa-mir-133b Atrial Fibrillation 3p expression was mainly associated with AD grade (p < 0.05), while miR-133b was related to both AD (p < 0.005) and AF (p < 0.05), the two factors exerting opposite modulation effects. +other 31551809 hsa-mir-590 Atrial Dilatation 5p. +other 31551809 hsa-mir-28 Atrial Dilatation 3p expression was mainly associated with AD grade (p < 0.05), while miR-133b was related to both AD (p < 0.005) and AF (p < 0.05), the two factors exerting opposite modulation effects. +other 31551809 hsa-mir-29a Atrial Fibrillation 5p. +other 31551809 hsa-mir-208b Atrial Dilatation 5p. +other 31551809 hsa-mir-28 Atrial Fibrillation 3p expression was mainly associated with AD grade (p < 0.05), while miR-133b was related to both AD (p < 0.005) and AF (p < 0.05), the two factors exerting opposite modulation effects. +other 31551809 hsa-mir-1 Atrial Dilatation 5p. +other 31551809 hsa-mir-1 Atrial Fibrillation 5p. +other 31551809 hsa-mir-208b Atrial Fibrillation 5p. +other 31551809 hsa-mir-133b Atrial Dilatation 3p expression was mainly associated with AD grade (p < 0.05), while miR-133b was related to both AD (p < 0.005) and AF (p < 0.05), the two factors exerting opposite modulation effects. +other 31551809 hsa-mir-29a Atrial Dilatation 5p. +other 31551809 hsa-mir-590 Atrial Fibrillation 5p. +lncRNA target 31551710 hsa-mir-145a Inflammation Our study demonstrated that lncRNA TUG1, sponging miR-145a-5p with negative interaction, could regulate microglial polarization and production of inflammatory cytokines at a relatively early stage after OGD insult, where NF-kappaB pathway might be involved, possibly providing a promising therapeutic target against inflammatory injury. +other 31551516 hsa-mir-223 Prostatic Neoplasms 3p miR-374b-5p] model (AUC: 0,891) to discriminate between GS >/= 7 tumours and men presenting PSA >/= 4 ng/ml with no cancer or GS6 tumours (Sn:81,8% Sp:95% vs Sn:54,5% Sp:90%). +other 31551516 hsa-mir-374b Prostatic Neoplasms 3p miR-374b-5p] model (AUC: 0,891) to discriminate between GS >/= 7 tumours and men presenting PSA >/= 4 ng/ml with no cancer or GS6 tumours (Sn:81,8% Sp:95% vs Sn:54,5% Sp:90%). +other 31551516 hsa-mir-342 Prostatic Neoplasms 3p miR-374b-5p] model (AUC: 0,891) to discriminate between GS >/= 7 tumours and men presenting PSA >/= 4 ng/ml with no cancer or GS6 tumours (Sn:81,8% Sp:95% vs Sn:54,5% Sp:90%). +other 31551516 hsa-mir-142 Prostatic Neoplasms 3p miR-374b-5p] model (AUC: 0,891) to discriminate between GS >/= 7 tumours and men presenting PSA >/= 4 ng/ml with no cancer or GS6 tumours (Sn:81,8% Sp:95% vs Sn:54,5% Sp:90%). +genetics_overexpression_suppress 31551498 hsa-mir-361 Parkinson Disease There was a significant overexpression of miR-885 and miR-17 and the downregulation of miR-361 in the PD patients compared to the controls. On the other hand, the lower levels of miR-361 in the early stages of the PD patients, as compared to controls, and its higher levels in the advanced stages of PD patients, as compared to the early stages of the PD patients, were observed. +lncRNA target 31551242 hsa-mir-203 Carcinoma, Hepatocellular Mechanistically, we found that circPVT1 could bind directly to miR-203 and contributed to the initiation and progression of HCC by regulating miR-203/homebox D3 (HOXD3) pathway. In conclusion, our study reveals that circPVT1 participates in the progression of HCC through the miR-203/homeobox D3 (HOXD3) pathway and might represent a potential therapeutic target for HCC treatment. +lncRNA target 31551149 hsa-mir-140 Osteoporosis MSC-AS1 might promote the osteogenic differentiation of BMSCs through sponging microRNA5p to up-regulate BMP2, thus alleviating the progression of osteoporosis. +genetics_overexpression_promote 31550855 hsa-mir-29 Carcinoma, Hepatocellular After HCC cells were transfected with HULC overexpressed plasmid or siRNA, the expressions of miR-29 and its target gene SETDB1 were determinate by RT-qPCR. +transcription factor target 31550815 hsa-mir-28 Diabetes Mellitus Conclusion: miR-328 can inhibit the differentiation of ESCs into IPCs via binding to 3' UTR of TGF-beta2, and provide a new regulatory pathway for the treatment of diabetes with stem cells. +genetics_knock down_suppress 31550677 hsa-mir-148a Ovarian Neoplasms It interacted with miR-148a-3p/ROCK1, and miR-148a-3p inhibitors rescued the anti-tumor effect of LINC00339 knockdown on proliferation, migration, and invasion of ovarian cancer cells. CONCLUSION: LINC00339 regulated ovarian cancer cell proliferation, migration, and invasion by targeting miR-148a-3p/ROCK1 axes, which provided novel insights for ovarian cancer diagnosis and therapy. +lncRNA target 31550675 hsa-mir-429 Carcinoma, Renal Cell CONCLUSION: In summary, we propose that SCAMP1 affects RCC tumorigenesis through miR-429 and its downstream targets. +other 31550669 hsa-mir-1 Acute Coronary Syndrome Two miRNAs (hsa-miR-29 and hsa-miR-1) and three TFs (NFIC, NFKB1 and RELA) were critical genes involved in pathological process of ACS. +other 31550669 hsa-mir-29 Acute Coronary Syndrome Two miRNAs (hsa-miR-29 and hsa-miR-1) and three TFs (NFIC, NFKB1 and RELA) were critical genes involved in pathological process of ACS. +exosome 31549864 hsa-mir-23 Polycystic Ovary Syndrome The results demonstrated that exosomal miR +transcription factor target 31549733 hsa-mir-210 Cholestatic Liver Injury The miRMLL4 axis is a potential target for the treatment of BA-associated hepatobiliary disease. +other 31549595 hsa-mir-892c Breast Neoplasms 3p in breast cancer cells. +other 31549595 hsa-mir-198 Breast Neoplasms 3p in breast cancer cells. +other 31549595 hsa-mir-3171 Breast Neoplasms 3p in breast cancer cells. +other 31549595 hsa-mir-933 Breast Neoplasms 3p in breast cancer cells. +other 31549595 hsa-mir-5194 Breast Neoplasms 3p in breast cancer cells. +other 31549595 hsa-mir-5006 Breast Neoplasms 3p in breast cancer cells. +lncRNA target 31549407 hsa-mir-204 Carcinoma, Hepatocellular And rescue assays demonstrated that NEAT1 promotes HCC autophagy through modulating miR-204/ATG3 pathway. Collectively, this study first demonstrated that a novel NEAT1/miR-204/ATG3 signaling regulates HCC progression. +genetics_knock down_promote 31549406 hsa-mir-2467 Colorectal Neoplasms Rescue assays verified that MMP14 knockdown countervailed the function of miR +lncRNA target 31548493 hsa-mir-326 Carcinoma, Hepatocellular In conclusion, we propose that SNHG3 promotes HCC progression via the miR-326/SMAD3/ZEB1 signaling pathway. +lncRNA target 31548493 hsa-mir-326 Osteosarcoma Small nucleolar RNA host gene 3 (SNHG3), a long noncoding RNA (lncRNA), acts as an oncogene in hepatocellular carcinoma (HCC), whereas microRNA (miR)-326 plays an inhibitory role in some types of human cancers, including melanoma, osteosarcoma, and gastric cancer. +lncRNA target 31548493 hsa-mir-326 Melanoma Small nucleolar RNA host gene 3 (SNHG3), a long noncoding RNA (lncRNA), acts as an oncogene in hepatocellular carcinoma (HCC), whereas microRNA (miR)-326 plays an inhibitory role in some types of human cancers, including melanoma, osteosarcoma, and gastric cancer. +lncRNA target 31548493 hsa-mir-326 hereditary diffuse gastric cancer Small nucleolar RNA host gene 3 (SNHG3), a long noncoding RNA (lncRNA), acts as an oncogene in hepatocellular carcinoma (HCC), whereas microRNA (miR)-326 plays an inhibitory role in some types of human cancers, including melanoma, osteosarcoma, and gastric cancer. +circulation_biomarker_diagnosis_ns 31548167 hsa-mir-125b Fibrosis RESULTS: miR-125b was significantly declined in serum samples of the clinical liver fibrosis patient, activated LX2 cells and the liver tissues of the CCl(4)-induced rat model. +genetics_knock down_promote 31547991 hsa-mir-217 Urinary Bladder Neoplasms Furthermore, knockdown of miRNA-217 attenuated viability and migration in bladder cancer cells. +genetics_overexpression_promote 31547835 hsa-mir-601 Stomach Neoplasms The overexpression of miR-601 promotes the tumor progression of GC, and may be a novel prognostic factor for poor survival in GC patients. +circulation_biomarker_diagnosis_ns 31547152 hsa-mir-122 Hepatitis C To test whether miR-122 levels could be utilized as a biomarker of hepatic adaptive stress response in HCV infection, serum miR-122 level was measured among healthy controls, and chronic HCV patients with or without cirrhosis. +circulation_biomarker_diagnosis_ns 31547152 hsa-mir-122 Liver Cirrhosis To test whether miR-122 levels could be utilized as a biomarker of hepatic adaptive stress response in HCV infection, serum miR-122 level was measured among healthy controls, and chronic HCV patients with or without cirrhosis. +other 31546954 hsa-mir-497 Colorectal Neoplasms 5p replacement enhanced sensitivity to oxaliplatin in treatment naive MSI/P53 wild-type CRC cells. +other 31546954 hsa-mir-195 Colorectal Neoplasms 5p replacement enhanced sensitivity to oxaliplatin in treatment naive MSI/P53 wild-type CRC cells. +epigenetics 31546665 hsa-mir-137 Colorectal Neoplasms Surprisingly, the methylation frequency of miR-342 (76.3%) among colorectal cancer patients was significantly higher compared to miR-137 (18.6%). Methylation status of miRNA-137 and miRNA-342 has both diagnostic and prognostic value in CRC prediction and prevention. +epigenetics 31546665 hsa-mir-342 Colorectal Neoplasms Surprisingly, the methylation frequency of miR-342 (76.3%) among colorectal cancer patients was significantly higher compared to miR-137 (18.6%). Methylation status of miRNA-137 and miRNA-342 has both diagnostic and prognostic value in CRC prediction and prevention. +genetics_knock down_promote 31546610 hsa-mir-22 Dmd-Associated Dilated Cardiomyopathy CONCLUSION: We identified, in human DCM, a complex series of events whose key players are miR-22, PP2Cm, BCAA, mTOR, and ALP, linking loss of proteostasis with inflammasome activation. +other 31546389 hsa-mir-148b Jequier Kozlowski skeletal dysplasia In this study, we aimed to engineer three-dimensional (3D) printed hybrid scaffolds as a new ex situ miR-148b expressing delivery system for osteogenic induction of rat bone marrow stem cells (rBMSCs) in vitro, and also in vivo in critical-sized rat calvarial defects. +other 31546259 hsa-mir-449b Diabetes Mellitus, Type 1 Rs10061133 in MIR449b was protective of sight-threatening DR (odds ratio [OR] = 0.32, P = 3.68 x 10-4) and PDR (OR = 0.30, P = 8.12 x 10-4), and the associations became more significant as the cohort increased in size. CONCLUSIONS: Rs10061133 in MIR449b is significantly associated with a decreased risk of PDR and sight-threatening DR in Caucasian patients with type 1 diabetes. +other 31546259 hsa-mir-449b Diabetic Retinopathy Rs10061133 in MIR449b was protective of sight-threatening DR (odds ratio [OR] = 0.32, P = 3.68 x 10-4) and PDR (OR = 0.30, P = 8.12 x 10-4), and the associations became more significant as the cohort increased in size. CONCLUSIONS: Rs10061133 in MIR449b is significantly associated with a decreased risk of PDR and sight-threatening DR in Caucasian patients with type 1 diabetes. +lncRNA target 31546213 hsa-mir-122 Arsenic Poisoning Taken together, our findings show that the miR-122/PKM2 autophagy axis protects hepatocytes from arsenite stress via the PI3K/Akt/mTOR pathway; thus, miR-122 may be a potential candidate in the treatment of arseniasis. +genetics_GWAS 31546198 hsa-let-7f Colorectal Neoplasms In the present study, in a case-control setup, 167 CRC patients and 161 control subjects were studied for allele and genotype frequency of rs10889677 polymorphism in miRNAs Let-7e and Let-7f binding sites at 3' UTR of IL23R gene using PCR-RFLP assay. +lncRNA target 31545986 hsa-mir-208a Hypoxia The pro-apoptosis potential and mechanism of miR-208a for oxidative injury were evaluated by MTT, flow cytometry, qRT-PCR and Western blot assays. We foundthatmiR-208a mimic aggravated H(2)O(2)-induced apoptosis and oxidative injury in cardiomyocytes, while miR-208a inhibitor hadan inverse effect. +other 31545986 hsa-mir-208a Cardiomyopathies A new signaling pathway miR-208a/APC was first observed in myocardial injury. +genetics_overexpression_promote 31545930 hsa-mir-200 Prostatic Neoplasms In PC cells, IUR and miR-200 overexpression mediated the downregulated ZEB1. +lncRNA target 31545928 hsa-mir-93 Diabetic Nephropathies 5p-dependent CDKN1A inhibition was beneficial for preventing renal interstitial fibrosis in DN, which may provide a future strategy to prevent the progression of DN. +lncRNA target 31545928 hsa-mir-93 Fibrosis, Renal 5p-dependent CDKN1A inhibition was beneficial for preventing renal interstitial fibrosis in DN, which may provide a future strategy to prevent the progression of DN. +other 31545515 hsa-mir-34a Carcinoma, Non-Small-Cell Lung MicroRNA-34a-5p regulates the G1/S checkpoint in non-small cell lung cancer (NSCLC) cells. +circulation_biomarker_diagnosis_up 31545496 hsa-mir-146a Dermatitis, Atopic miR146a expression was measured in AD patient serum via reverse transcriptionquantitative PCR. +lncRNA target 31545491 hsa-mir-96 Glioma In summary, the present data provided novel insight into the roles of MEG3 in glioma, and MEG3/miR965p/MTSS1 signaling could be a promising therapeutic target for the treatment of patients with glioma. +circRNA target 31545480 hsa-mir-1231 Urinary Bladder Neoplasms Using highthroughput sequencing, this study revealed the circRNA expression profiles of different grades of BC and proposed that the novel circRNA, hsa_circ_0137606, suppresses BC proliferation and metastasis by sponging miR1231. +genetics_overexpression_promote 31545479 hsa-mir-141 Carcinoma, Hepatocellular Overexpression of miR141 in HCC cells robustly impaired migration and invasion and suppressed proliferation in vitro, by arresting cells at the G2/M phase. +lncRNA target 31545465 hsa-mir-4712 Vulvar Neoplasms The aim of the present study was to screen differentially expressed miRNAs in vulvar squamous cell carcinoma (VSCC), observe the role of microRNA47125p in VSCC and investigate its targets and regulatory mechanism. +genetics_overexpression_promote 31545460 hsa-mir-203a Colorectal Neoplasms The overexpression of miR203a3p was shown to inhibit the invasion and migration of human CRC SW480 and HT29 cells, and increase their apoptosis rates. +lncRNA target 31545458 hsa-mir-942 Carcinoma, Renal Cell Through the integrated analysis of RNAsequencing and TCGA data, an miR942related ceRNA network, which was predicted to significantly affect the survival of patients with RCC, was constructed. +transcription factor target 31545430 hsa-mir-381 Stomach Neoplasms Taken together, the present study demonstrated that miR381 is downregulated in GC cells, and that miR381 may inhibit GC cell growth. +other 31545429 hsa-mir-92a Autoimmune polyendocrinopathy syndrome, type 1 The onset of AP is characterized by early trypsinogen activation.The present study aimed to investigate the expression of microRNA (miR)92a3p and early growth response protein 1 (Egr1), and the effect of miR92a3p on trypsinogen activation in the pancreatic exocrine cell line AR42J. +exosome 31545424 hsa-mir-376b Breast Neoplasms A total of five miRNAs, including miRNA375, miRNA2425p, miRNA548b5p, miRNA6553P and miRNA376b5p, were synchronized in extracellular vesicles and tissues of the breast cancer group when compared with the healthy group. +exosome 31545424 hsa-mir-375 Breast Neoplasms A total of five miRNAs, including miRNA375, miRNA2425p, miRNA548b5p, miRNA6553P and miRNA376b5p, were synchronized in extracellular vesicles and tissues of the breast cancer group when compared with the healthy group. +exosome 31545424 hsa-mir-655 Breast Neoplasms A total of five miRNAs, including miRNA375, miRNA2425p, miRNA548b5p, miRNA6553P and miRNA376b5p, were synchronized in extracellular vesicles and tissues of the breast cancer group when compared with the healthy group. +exosome 31545424 hsa-mir-548b Breast Neoplasms A total of five miRNAs, including miRNA375, miRNA2425p, miRNA548b5p, miRNA6553P and miRNA376b5p, were synchronized in extracellular vesicles and tissues of the breast cancer group when compared with the healthy group. +exosome 31545424 hsa-mir-242 Breast Neoplasms A total of five miRNAs, including miRNA375, miRNA2425p, miRNA548b5p, miRNA6553P and miRNA376b5p, were synchronized in extracellular vesicles and tissues of the breast cancer group when compared with the healthy group. +circulation_biomarker_diagnosis_ns 31545413 hsa-mir-101-1 Pulmonary Disease, Chronic Obstructive miRNA1013p.1 profiles in peripheral blood mononuclear cells of COPD patients were evaluated. +genetics_knock down_promote 31545407 hsa-mir-133b Breast Neoplasms In addition, small interfering RNAmediated knockdown of TGFbetaR1 mimicked the phenotype of miR133b overexpression in BC cells. +other 31545328 hsa-mir-155 Staphylococcal Infections Selenium (Se) can activate pivotal proteins in immune responses and regulate the immune system, and microRNA-155 (miR-155) is a key transcriptional regulator for inflammation-related diseases. +other 31545328 hsa-mir-155 Mastitis Selenium (Se) can activate pivotal proteins in immune responses and regulate the immune system, and microRNA-155 (miR-155) is a key transcriptional regulator for inflammation-related diseases. +genetics_knock down_promote 31545291 hsa-mir-122 Carcinoma, Hepatocellular 5p knockdown or RPL4 restoration partially reversed SNHG7 silencing-induced tumor suppressive effects on HCC cells. +other 31545253 hsa-mir-153 Uterine Cervical Neoplasms 3p/KIF20A axis promoting CC progression, which may suggest a new insight into the pathogenesis of CC. +lncRNA target 31545249 hsa-mir-135a Atherosclerosis Moreover, GAS5 directly targeted miR-135a and repressed miR-135a expression. +other 31545240 hsa-mir-133b Glioma These findings elucidated that EGFR-AS1 accelerated cell proliferation, migration, invasion and prevented apoptosis in glioma cells by regulating miR-133b/RACK1, providing new insights for the diagnosis and molecular therapy of GBM. +lncRNA target 31545237 hsa-mir-761 Carcinoma, Non-Small-Cell Lung Additional, the results of Transwell invasion and colony formation experiments indicated that FENDRR inhibited the aggressiveness of NSCLC depend on miR-761. Altogether, we demonstrated that lncRNA FENDRR suppressed the progression of NSCLC via binding to miR-761 and regulating TIMP2 expression. +lncRNA target 31545233 hsa-let-7f Lupus Erythematosus, Systemic In conclusion, our study suggested that high level of let-7f-5p alleviated inflammation in SLE-BMSCs at least partly through targeting NLRP3, highlighting let-7f-5p as a novel promising therapeutic strategy for SLE treatment. +transcription factor target 31545231 hsa-mir-377 Atherosclerosis Further analysis indicated that over-expression of miR-377 partly alleviated the development of AS by down-regulating the expression of the Syk gene. This study identifies a novel role of miR-377 in AS via targeting Syk. +other 31545228 hsa-mir-149 Prostatic Neoplasms, Castration-Resistant 5p, and miR-378a-3p, involving in the PI3K-Akt pathway in the treatment of CRPC. +other 31545228 hsa-mir-378a Prostatic Neoplasms, Castration-Resistant 5p, and miR-378a-3p, involving in the PI3K-Akt pathway in the treatment of CRPC. +other 31545228 hsa-mir-378c Prostatic Neoplasms, Castration-Resistant 5p, and miR-378a-3p, involving in the PI3K-Akt pathway in the treatment of CRPC. +other 31545228 hsa-mir-140 Prostatic Neoplasms, Castration-Resistant 5p, and miR-378a-3p, involving in the PI3K-Akt pathway in the treatment of CRPC. +other 31545228 hsa-mir-34b Prostatic Neoplasms, Castration-Resistant 5p, and miR-378a-3p, involving in the PI3K-Akt pathway in the treatment of CRPC. +other 31545228 hsa-mir-29b Prostatic Neoplasms, Castration-Resistant 5p, and miR-378a-3p, involving in the PI3K-Akt pathway in the treatment of CRPC. +other 31545228 hsa-mir-674 Prostatic Neoplasms, Castration-Resistant 5p, and miR-378a-3p, involving in the PI3K-Akt pathway in the treatment of CRPC. +other 31545227 hsa-mir-134 Stomach Neoplasms CONCLUSIONS: LncRNA LUCAT1 could promote proliferation and invasion of gastric cancer by regulating miR5p/YWHAZ axis. +other 31545079 hsa-mir-519d Urinary Bladder Neoplasms In addition, the downregulated miR-519d might lead to the development of BC by upregulating the expression of CENPO. +lncRNA target 31545000 hsa-mir-145 Ovarian Neoplasms Further results demonstrated that miR-145 is the direct binding target of DANCR during regulation of VEGF expression and tumor angiogenesis in ovarian cancer cells. Collectively, DANCR plays a promotional role in tumor angiogenesis in ovarian cancer through regulation of miR-145/VEGF axis. +genetics_overexpression_suppress 31544978 hsa-mir-203 Colonic Neoplasms Here, we show that overexpression and sequestration of miR-203 in HCT-116 and HT-29 human CRC cells reduces and enhances their stemness, respectively. +lncRNA target 31544897 hsa-mir-34a Breast Neoplasms CONCLUSIONS LncRNA UFC1 regulated biological activity of breast cancer via miR-34a/CXCL10 axis, providing a novel diagnosis biomarker and potential therapeutic target for breast cancer. +lncRNA target 31544687 hsa-mir-146a Choriocarcinoma After the transfection of BeWo choriocarcinoma cell (BeWo cell) with miR-146a-5p mimic, M-NC, inhibitor and IN-NC, the mRNA expression of Caspase-3, BAX and Bcl-2 was measured using qRT-PCR, and the cell proliferation was measured using CCK-8 kit. +other 31544253 hsa-mir-505 Choroid Diseases Our data have uncovered the critical contribution of miR-505 in AMD, which is predominantly mediated by downregulation of TMEM229B. +lncRNA target 31544245 hsa-mir-204 Esophageal Squamous Cell Carcinoma 5p functions as a tumor suppressor by directly targeting IL-11 in ESCC. +other 31543683 hsa-mir-874 Liver Neoplasms Among them, some of the regulators also had persistent disorders in the process of HBV-HCC including microRNA-192, microRNA-215, and microRNA-874, and early growth response 2, FOS, and Kruppel-like factor 4. +other 31543683 hsa-mir-215 Liver Neoplasms Among them, some of the regulators also had persistent disorders in the process of HBV-HCC including microRNA-192, microRNA-215, and microRNA-874, and early growth response 2, FOS, and Kruppel-like factor 4. +other 31543683 hsa-mir-874 Hepatitis B Among them, some of the regulators also had persistent disorders in the process of HBV-HCC including microRNA-192, microRNA-215, and microRNA-874, and early growth response 2, FOS, and Kruppel-like factor 4. +other 31543683 hsa-mir-192 Hepatitis B Among them, some of the regulators also had persistent disorders in the process of HBV-HCC including microRNA-192, microRNA-215, and microRNA-874, and early growth response 2, FOS, and Kruppel-like factor 4. +other 31543683 hsa-mir-192 Liver Neoplasms Among them, some of the regulators also had persistent disorders in the process of HBV-HCC including microRNA-192, microRNA-215, and microRNA-874, and early growth response 2, FOS, and Kruppel-like factor 4. +other 31543683 hsa-mir-215 Hepatitis B Among them, some of the regulators also had persistent disorders in the process of HBV-HCC including microRNA-192, microRNA-215, and microRNA-874, and early growth response 2, FOS, and Kruppel-like factor 4. +lncRNA target 31543513 hsa-mir-29a Osteoporosis Taken together, miR-29a signaling in osteogenic cells protects bone tissue from osteoporosis through repressing osteoclast regulators RANKL and CXCL12 to reduce osteoclastogenic differentiation. +genetics_overexpression_promote 31543507 hsa-mir-375 Colorectal Neoplasms Overexpression of miR-375 sensitized CRC cells to a broad spectrum of chemotherapeutic drugs in vitro and in vivo. +transcription factor target 31543343 hsa-mir-122 Liver Diseases MiR-122 is well recognized as a promising therapeutic target in liver disease, whereas recently plays important roles in cardiovascular diseases. +transcription factor target 31543343 hsa-mir-122 Cardiovascular Diseases MiR-122 is well recognized as a promising therapeutic target in liver disease, whereas recently plays important roles in cardiovascular diseases. +lncRNA target 31542994 hsa-mir-4456 Sexual Dysfunctions, Psychological Gene target prediction and pathway analysis revealed that MIR4456 putatively targets genes preferentially expressed in brain and that are involved in major neuronal molecular mechanisms thought to be relevant for HD, e.g., the oxytocin signalling pathway. +genetics_overexpression_promote 31542615 hsa-mir-7 Stomach Neoplasms 5p or overexpressed REGgamma reversed the promoting effects of downregulated CircRNA CDR1as on low-dose DB-induced GC cell death. +lncRNA target 31542613 hsa-mir-139 Hemangioma This study demonstrates that downregulatuon of linc00152 restrains the aggressiveness of hemangioma cell in vitro and in vivo via interacting with miR5p and further modulates the level of TPD52. +transcription factor target 31542480 hsa-mir-204 Hypertension, Pulmonary While down-regulation of miR-204 in PASMCs reportedly promoted monocrotaline-induced pulmonary arterial hypertension via increased cell proliferation, our data suggested an important, albeit dichotomous, role of miR-204 down-regulation in endothelial cells in the process of EndMT that it attenuated EndMT by enhancing autophagy, thereby ameliorating hypoxia-induced PH to some extent. +transcription factor target 31542480 hsa-mir-204 Diabetic Retinopathy While down-regulation of miR-204 in PASMCs reportedly promoted monocrotaline-induced pulmonary arterial hypertension via increased cell proliferation, our data suggested an important, albeit dichotomous, role of miR-204 down-regulation in endothelial cells in the process of EndMT that it attenuated EndMT by enhancing autophagy, thereby ameliorating hypoxia-induced PH to some extent. +lncRNA target 31541886 hsa-mir-25 Melanoma We used qRT-PCR to detect FOXD3-AS1, miR-325 and MAP3K2 expression in different staging samples and cutaneous melanoma cell lines. CONCLUSION: LncRNA FOXD3-AS1 could promote proliferation, invasion and migration of cutaneous malignant melanoma via regulating miR-325/MAP3K2 axis. +genetics_overexpression_promote 31541797 hsa-mir-494 Myocardial Infarction In conclusion, this study provided evidence suggesting that overexpressed miR-494 could potentially promote the proliferation, migration, and invasion of fibroblasts and VECs in MI through the inactivation of the Wnt signaling pathway by binding to LRG1. +transcription factor target 31541468 hsa-mir-122 Triple Negative Breast Neoplasms 5p promotes aggression and EMT in TNBC by suppressing CHMP3 through MAPK signaling. +lncRNA target 31541467 hsa-mir-204 Esophageal Squamous Cell Carcinoma In summary, this study revealed that linc-ROR modulated cell apoptosis and regulated p53 ubiquitination via targeting miR +lncRNA target 31541458 hsa-mir-188 Breast Neoplasms In conclusion, our results revealed that miR-188 is a cancer progression suppressor and a promising future target for breast cancer therapy. +other 31541457 hsa-mir-21 Breast Neoplasms Inspired by the way the toxin can become active in eukaryotes cells, we produced an engrained yoeB-yefM TA system to selectively kill human breast cancer cells expressing a high level of miR-21. +genetics_overexpression_suppress 31541079 hsa-mir-193a Hepatoblastoma Functional experiments demonstrated that overexpression of miR-193a-5p significantly inhibited cell proliferation and invasion of HB cells, while the inhibitory effect could be reversed by DPEP1 overexpression. +genetics_knock down_promote 31541075 hsa-mir-4521 Medulloblastoma In tissue samples obtained from medulloblastoma patients, the significant upregulation of FOXM1 was associated with a loss of its putative regulating microRNA, miR-4521. +genetics_knock down_suppress 31540772 hsa-mir-137 Colorectal Neoplasms Collectively, these findings suggest that TINCR knockdown inhibits TCF4 by regulating miR-137 expression. +other 31540771 hsa-mir-182 Multiple Myeloma Moreover, miR-182 up-regulation and PDCD4 down-regulation enhanced AKT phosphorylation at Ser473 in both H929 and MM.1S cells. +lncRNA target 31540582 hsa-mir-29b Burns RESULTS: The expressions of XIST and COL1A1 were enhanced but miR-29b-3p expression was decreased after thermal injury. CONCLUSION: XIST promoted ECM synthesis, cell proliferation and migration by sponging miR-29b-3p and targeting COL1A1 in HSF cells after thermal injury, indicating the promoting role of XIST in wound healing. +other 31540513 hsa-mir-374b Mouth Neoplasms Thus, the current study suggested that the miR-374b/PTEN signaling pathway possibly plays an important role in CoMM radiosensitivity. +other 31540331 hsa-mir-148 Corneal Diseases 5p-TBX6 were validated as possible miRNA regulations involved in corneal epithelial cells treated with 0.003% atropine. +other 31540331 hsa-mir-651 Corneal Diseases 5p-TBX6 were validated as possible miRNA regulations involved in corneal epithelial cells treated with 0.003% atropine. +other 31539877 hsa-mir-23a Diabetes, Gestational RESULTS: Two upregulated microRNAs (miR-223 and miR-23a) were identified in GDM vs the control set, and validated on a new cohort of women. +other 31539877 hsa-mir-223 Diabetes, Gestational RESULTS: Two upregulated microRNAs (miR-223 and miR-23a) were identified in GDM vs the control set, and validated on a new cohort of women. +genetics_overexpression_promote 31539861 hsa-mir-27b Stomach Neoplasms Overexpression of miR-27b-3p inhibited MKN-45 and SGC-7901 cell proliferation, invasion, and migration. +genetics_overexpression_promote 31539518 hsa-mir-615 Prostatic Neoplasms Moreover, overexpression of miR +genetics_GWAS 31539274 hsa-mir-22 Lung Neoplasms In addition, the results of expression quantitative trait loci analysis suggested that the rs9224 polymorphism affects the expression of FAM13A (p = 0.050) and miRNA +other 31539270 hsa-mir-34a Stomach Neoplasms Background: To investigate the effects of curcumin on miR-34a and proliferation of gastric cancer cells. Materials and Methods: Human gastric cancer cell line SGC-7901 was divided into control, curcumin, miR-34a agomir (miR-34a), miR-34a agomir negative control, and curcumin combined miR-34a antagomir (combine) groups. +genetics_overexpression_promote 31539153 hsa-mir-150 Myocardial Infarction, Acute After AMI procedures, the rats were injected with microRNA-150 lentivirus overexpression or negative control, respectively. +other 31539144 hsa-mir-375 Inflammatory Bowel Diseases CONCLUSIONS: Hsa-miR-375 is involved in the pathogenesis of IBD by upregulating TLR4 and inducing NF-kappaB activation. +genetics_knock down_promote 31539138 hsa-mir-378a Leukemia, Myeloid, Acute The regulating associations between LINC00641, miR-378a, and ZBTB20 were investigated in AML cells using the Luciferase reporter assays and RT-PCR assays RESULTS: We found that LINC00641 was highly expressed in AML specimens and cell lines. CONCLUSIONS: We firstly identified LINC00641 as a novel AML-related lncRNA whose knockdown inhibited cell proliferation, migration, invasion, and promoted apoptosis by modulating miR-378a/ZBTB20 axis in AML. +genetics_overexpression_promote 31539136 hsa-mir-199a Glioma Furthermore, MARCH8 overexpression could partially reverse the effects of miR-199a-5p on glioma cells. +circulation_biomarker_diagnosis_down 31539134 hsa-mir-214 Breast Neoplasms It has been shown that there were significant differences between the expression levels of serum miR +lncRNA target 31539133 hsa-mir-185 Breast Neoplasms CONCLUSIONS: LINC00511 inhibition impairs its competitive binding to miR-185, resulting in increased STXBP4 expression and improved radiation response in breast cancer. Our study results suggest that the LINC00511/miR-185/STXBP4 axis may be a promising therapeutic target for improving the prognosis of breast cancer. +genetics_knock down_promote 31539132 hsa-mir-3130 Triple Negative Breast Neoplasms CONCLUSIONS: Knockdown of LINC01096 inhibited cell viability, migration, and invasion; however, it promoted apoptosis in TNBC by up-regulating miR +transcription factor target 31539130 hsa-mir-142 Lung Neoplasms MiR-142 can inhibit lung cancer cell proliferation and induce apoptosis through inhibition of XIAP expression. +lncRNA target 31539128 hsa-mir-203a Carcinoma, Non-Small-Cell Lung Briefly, LINC00342 contributes to NSCLC cells growth and metastasis via targeting miR-203a-3p competitively. +genetics_overexpression_promote 31539127 hsa-mir-23a Carcinoma, Non-Small-Cell Lung Overexpression of MAGI2-AS3 suppresses the proliferative and invasive abilities of NSCLC via miRNA-23a-3p/PTEN axis. +lncRNA target 31539126 hsa-mir-155 Nasopharyngeal Carcinoma CONCLUSIONS: In nasopharyngeal carcinoma CNE-1 cell line, miR-155 can inhibit the proliferation and promote apoptosis of nasopharyngeal carcinoma cells by targeting PI3K/AKT-FOXO3a signaling. +lncRNA target 31539124 hsa-mir-99a Stomach Neoplasms The Dual-Luciferase reporter assay was performed to confirm miR-99a mediated the expression of IGF1R by directly targeting its mRNA 3'-untranslated regions (3'-UTR) in gastric cancer cells. +genetics_knock down_promote 31539122 hsa-mir-361 Cholangiocarcinoma Further functional analysis showed that the knockdown of TRAF3 upregulated the expression of p-p65 decreased by miR +lncRNA target 31539118 hsa-mir-9 Uterine Cervical Neoplasms 5p could affect angiogenesis and radiosensitivity of CC cells by targeting SOCS5. +lncRNA target 31539116 hsa-mir-30 Uterine Cervical Neoplasms 5p to modulate the expression levels of ELK1 and may be explored as a novel target for developing therapeutic strategies for the treatment of cervical cancer. +other 31539115 hsa-mir-144 Ovarian Neoplasms CONCLUSIONS: CircUBAP2 promotes the progression of ovarian cancer by adsorbing microRNA-144. +lncRNA target 31539114 hsa-mir-29 Osteosarcoma Increasing the expression of miR-29 can inhibit the proliferation of osteosarcoma cells and promote apoptosis by decreasing STAT3 expression. +lncRNA target 31539113 hsa-mir-1247 Osteosarcoma CONCLUSIONS: MiR-1247 played a suppressive role in OS by suppressing cell viability and metastasis. +lncRNA target 31539112 hsa-mir-153 Osteosarcoma 3p/ABCB1 axis, unraveling a new regulatory network of chemoresistance in cisplatin-resistant OS cells and may provide a therapeutic target for OS patients. +circulation_biomarker_diagnosis_ns 31539111 hsa-mir-373 Osteoporosis, Postmenopausal RESULTS: PCR results showed that the expression of miR-373 in the bone tissue and the serum of patients with postmenopausal osteoporosis was significantly reduced. +circulation_biomarker_diagnosis_ns 31539111 hsa-mir-373 Osteoporosis RESULTS: PCR results showed that the expression of miR-373 in the bone tissue and the serum of patients with postmenopausal osteoporosis was significantly reduced. +lncRNA target 31539108 hsa-mir-486 Polycystic Ovary Syndrome 5p can bind to MST4 in a targeted manner and inhibit the proliferation of ovarian granulosa cells, thereby inhibiting the development of PCOS. +lncRNA target 31539107 hsa-mir-200c Pre-Eclampsia CONCLUSIONS: MiR-200c is involved in the development and progression of PE through the Wnt/beta-catenin signaling pathway. +other 31539106 hsa-mir-2 Femoral Fractures RESULTS: The X-ray examination of the femoral fracture healing at postoperative 1 and 7 weeks revealed that the fracture line disappeared, and both callus formation and fracture healing were good in miR-25 mimics group. +other 31539106 hsa-mir-25 Femoral Fractures RESULTS: The X-ray examination of the femoral fracture healing at postoperative 1 and 7 weeks revealed that the fracture line disappeared, and both callus formation and fracture healing were good in miR-25 mimics group. +other 31538956 hsa-mir-7-2 Thyroid Cancer, Papillary 2-3p was significantly down-regulated and may act on PTC progression by crucial pathways. +genetics_overexpression_promote 31538724 hsa-mir-215 Breast Neoplasms 5p on breast carcinoma cells, and overexpression of Sox9 rescues the effects of miR +other 31538427 hsa-mir-146a Leukemia The expressions of miR-146a and ciliary neurotrophic factor receptor (CNTFR) were detected by quantitative real-time polymerase chain reaction (qRT-PCR) in ALL and AML pediatric patients, as well as ALL (Jurkat) and AML (HL-60) cells. RESULTS: miR-146a was increased in ALL and AML pediatric patients, while CNTFR was decreased. +lncRNA target 31538425 hsa-mir-183 Carcinoma, Hepatocellular CONCLUSION: CASC2 inhibited cell viability and the colony formation, migration, and invasion abilities of HCC cells by directly downregulating miR-183 through inactivation of the Wnt/beta-catenin signaling pathway. +other 31538414 hsa-mir-29a Angelman Syndrome The expression of miR-29a, DKK-1 and beta-catenin in normal and AS tissues were detected with real-time polymerase chain reaction (RT-PCR) and western blotting. +exosome 31537899 hsa-mir-144 Ovarian Failure, Premature Taken together, our experimental results provide new information regarding the potential of using exosomal miR5p to treat ovarian failure. +circulation_biomarker_diagnosis_ns 31537868 hsa-mir-21 Breast Neoplasms Serum and tissue miR-21 expression in patients with breast cancer (BC) is a useful biomarker for cancer diagnosis, progression, and treatment. Thus, miR-21 and MMP/CD63 may be useful markers for BC screening. +lncRNA target 31537542 hsa-mir-616 Celiac Disease Enrichment of proteins of mitochondria, known target organelles in CDC, was observed after miR-150, miR-328, and miR-616 inhibition. +lncRNA target 31537542 hsa-mir-28 Celiac Disease Enrichment of proteins of mitochondria, known target organelles in CDC, was observed after miR-150, miR-328, and miR-616 inhibition. +lncRNA target 31537542 hsa-mir-150 Celiac Disease Enrichment of proteins of mitochondria, known target organelles in CDC, was observed after miR-150, miR-328, and miR-616 inhibition. +genetics_overexpression_suppress 31537223 hsa-mir-21 Acute Lung Injury, Hyperoxic CONCLUSIONS: Overexpression of miR +genetics_overexpression_promote 31536904 hsa-mir-23b Brain Injuries In this study, we found miR-23b was downregulated in the ICH models and its overexpression effectively alleviated neurological deficits, brain edema, hematoma area, and neuronal apoptosis in ICH rats. +genetics_overexpression_promote 31536904 hsa-mir-23b Cerebral Hemorrhage In this study, we found miR-23b was downregulated in the ICH models and its overexpression effectively alleviated neurological deficits, brain edema, hematoma area, and neuronal apoptosis in ICH rats. +lncRNA target 31536479 hsa-mir-511 Pneumonia 3p regulates allergic inflammation and macrophage polarization by targeting Ccl2 and its downstream Ccr2/RhoA axis. +other 31536386 hsa-mir-590 Osteosarcoma 3p-AR-Tgfb1i1, miR-27a-3p-PPARG-Abca1, and miR-103/590-3p-AXIN2 axes. +lncRNA target 31535570 hsa-mir-21 Hepatoblastoma associated apoptosis in HB is mediated through ASPP2/p38 signaling pathway in vitro and in vivo. +genetics_knock down_suppress 31535411 hsa-mir-200c Carcinoma, Ovarian Epithelial The miR-200c overexpression in SKOV3 cells with transducted lentivirus-miR-200c can inhibit lncRNA HOTAIR expression, decrease snail, increase E-cadherin and significantly reduce the invasion and tumorigenicity of EOC SKOV3 cells. +lncRNA target 31535380 hsa-mir-150 Glioma Our results showed that ZFAS1 promoted glioma malignant progression by regulating the miR5p/PLP2 axis, which may provide a potential therapeutic target for the treatment of glioma. +genetics_GWAS 31535082 hsa-mir-147b Adenocarcinoma of Lung Further metabolomics and genetic studies demonstrate that osimertinib-tolerance is driven by miR-147b repression of VHL and succinate dehydrogenase linked to the tricarboxylic acid cycle and pseudohypoxia pathways. +other 31534967 hsa-mir-4286 Prostatic Neoplasms In the training phase with 78 PCa and 77 BPH cases, miR-365a-3p, miR-4286, miR5p, miR-27a-3p, and miR-29b-3p were found to have potential diagnostic value. +other 31534967 hsa-mir-27a Prostatic Neoplasms In the training phase with 78 PCa and 77 BPH cases, miR-365a-3p, miR-4286, miR5p, miR-27a-3p, and miR-29b-3p were found to have potential diagnostic value. +other 31534967 hsa-mir-424 Prostatic Neoplasms In the training phase with 78 PCa and 77 BPH cases, miR-365a-3p, miR-4286, miR5p, miR-27a-3p, and miR-29b-3p were found to have potential diagnostic value. +other 31534967 hsa-mir-29b Prostatic Neoplasms In the training phase with 78 PCa and 77 BPH cases, miR-365a-3p, miR-4286, miR5p, miR-27a-3p, and miR-29b-3p were found to have potential diagnostic value. +other 31534967 hsa-mir-365a Prostatic Neoplasms In the training phase with 78 PCa and 77 BPH cases, miR-365a-3p, miR-4286, miR5p, miR-27a-3p, and miR-29b-3p were found to have potential diagnostic value. +lncRNA target 31534537 hsa-mir-33a Prostatic Neoplasms Our results further revealed that recurrent ZEB1 upregulation induced by copy number gains transcriptionally inhibited miR-33a-5p expression, contributing to the reduced expression of miR-33a-5p in bone metastatic PCa tissues. +transcription factor target 31534516 hsa-mir-5787 Ehlers-Danlos Syndrome, musculocontractural type 1 Downregulation of miR-5787 inhibited the translation of MT-CO3 to regulate cisplatin resistance of TSCC. +exosome 31534509 hsa-mir-143 Acquired Immunodeficiency Syndrome In addition, 10E8(scFv)-exos loaded with Cur or miR-143 could suppress p24 expression in an HIV-1 latency cell line ACH2 and in PBMCs from an ART-treated HIV +exosome 31534509 hsa-mir-143 Epidermodysplasia Verruciformis 10E8(scFv)-exos loaded with Cur or miR-143 showed specific killing of Env(+) cells. +exosome 31534508 hsa-mir-20 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Some tumor suppressive miRNAs, especially miR-320, were enriched in exosomes and thus secreted by leukemic cells, resulting in increased proliferation of the donor cells. Conclusion: HNRNPA1-mediated exosomal transfer of miR-320 from leukemia cells to BMMSC is an important mediator of leukemia progression and is a potential therapeutic target for CML. +lncRNA target 31534499 hsa-mir-26a Glioma Therefore, AP-2alpha and miR-26a inhibition might represent a new target for developing new therapeutic strategies in TMZ resistance and recurrent glioma patients. +other 31534349 hsa-mir-145 Urinary Bladder Neoplasms 5p was upregulated in patients with bladder cancer. +genetics_overexpression_promote 31533781 hsa-mir-212 Siderosis Furthermore, we found that overexpression of miR +genetics_overexpression_promote 31533781 hsa-mir-212 Brain Injuries, Traumatic Furthermore, we found that overexpression of miR +lncRNA target 31533634 hsa-mir-101 Colorectal Neoplasms CONCLUSION: SNHG6 could regulate the progression of CRC via modulating the expression levels of miR3p and the activity of Wnt/beta-catenin signaling. +other 31533306 hsa-mir-152 Obesity The findings indicate that miR-152 might have a therapeutic significance for obesity and obesity-related metabolic syndrome. +other 31533233 hsa-mir-431 Hand, Foot and Mouth Disease miRNAs analysis identified miR-223 over-expression and miR-431 down-regulation in AYA, validated by Real-Time PCR and miRNA in situ hybridization (ISH). +other 31533233 hsa-mir-223 Hand, Foot and Mouth Disease miRNAs analysis identified miR-223 over-expression and miR-431 down-regulation in AYA, validated by Real-Time PCR and miRNA in situ hybridization (ISH). +transcription factor target 31533227 hsa-mir-34a Diabetic Angiopathies These results suggest that VAC impedes HG-induced endothelial dysfunction via inhibition of the ROS/AMPK/miRNA-34a/eNOS signaling cascade. +other 31533065 hsa-let-7c familial temporal lobe epilepsy 3 In particular, our data suggest that specific miRNAs (e.g., let-7b-3p and let-7c-3p) may be key regulators of multiple pathways related to MTLE pathology. +other 31533065 hsa-let-7b familial temporal lobe epilepsy 3 In particular, our data suggest that specific miRNAs (e.g., let-7b-3p and let-7c-3p) may be key regulators of multiple pathways related to MTLE pathology. +transcription factor target 31533001 hsa-mir-24 Neurotoxicity Syndromes To conclude, this study demonstrated that miR-24 attenuates isoflurane-induced neurotoxicity in rat hippocampus via its antioxidative properties and inhibiting p27(kip1) expression. +other 31532704 hsa-mir-144 Multiple Myeloma Moreover, BMSCs-CM showed the presence of VCAN which upon supplementing to MM cells alter parameters in favour of myeloma progression, however, this effect was neutralized by VCAN antibody or miR (miR-144 and miR-199) mimics. +other 31532704 hsa-mir-199 Multiple Myeloma Moreover, BMSCs-CM showed the presence of VCAN which upon supplementing to MM cells alter parameters in favour of myeloma progression, however, this effect was neutralized by VCAN antibody or miR (miR-144 and miR-199) mimics. +other 31532243 hsa-mir-140 Acute Kidney Injury 5p) implicated in AKI, poly(ADP-ribose) polymerase 1 levels, antiapoptotic signaling, intracellular NAD(+), and mitochondrial oxidative phosphorylation were observed in the treatment group. +other 31532243 hsa-mir-192 Acute Kidney Injury 5p) implicated in AKI, poly(ADP-ribose) polymerase 1 levels, antiapoptotic signaling, intracellular NAD(+), and mitochondrial oxidative phosphorylation were observed in the treatment group. +other 31532182 hsa-mir-141 Breast Neoplasms This platform was applied to investigate miRNA-141 expression in various cancer cells, which can accurately detect in the range of 100-100 000 MDA-MB-231 cells (breast cancer cell lines), with an LOD of 15 cells. +circulation_biomarker_diagnosis_up 31532140 hsa-mir-126 Ischemic Stroke EA treatment can 1) balance levels of miRNAs (such as mir-126 and mir-328, etc.) to promote angiogenesis of ischemic cerebral cortex tissue by regulating expression of vascular endothelial growth factor family genes and proteins; 2) promote nerve regeneration by up-regulating serum miR-124 and hippocampal miR-132 expression to possibly facilitate cerebral repair and reduce cognitive dysfunction respectively via related proteins; 3) reduce cerebral edema via modulating expression of some miRNAs to control expression of aquaporin, matrix metalloproteinases, etc. +circulation_biomarker_diagnosis_up 31532140 hsa-mir-28 Ischemic Stroke EA treatment can 1) balance levels of miRNAs (such as mir-126 and mir-328, etc.) to promote angiogenesis of ischemic cerebral cortex tissue by regulating expression of vascular endothelial growth factor family genes and proteins; 2) promote nerve regeneration by up-regulating serum miR-124 and hippocampal miR-132 expression to possibly facilitate cerebral repair and reduce cognitive dysfunction respectively via related proteins; 3) reduce cerebral edema via modulating expression of some miRNAs to control expression of aquaporin, matrix metalloproteinases, etc. +circulation_biomarker_diagnosis_up 31532140 hsa-mir-124 Ischemic Stroke EA treatment can 1) balance levels of miRNAs (such as mir-126 and mir-328, etc.) to promote angiogenesis of ischemic cerebral cortex tissue by regulating expression of vascular endothelial growth factor family genes and proteins; 2) promote nerve regeneration by up-regulating serum miR-124 and hippocampal miR-132 expression to possibly facilitate cerebral repair and reduce cognitive dysfunction respectively via related proteins; 3) reduce cerebral edema via modulating expression of some miRNAs to control expression of aquaporin, matrix metalloproteinases, etc. +lncRNA target 31532132 hsa-mir-133a Muscular Atrophy Following EA intervention, the decreased levels of the ratio of wet weight and CSA of the gastrocnemius muscle were significantly suppressed (P<0.01), suggesting an inhibition of the skeletal muscle atrophy, and the expression levels of Pax7 and HDAC4 mRNAs were notably up-regulated (P<0.05), and those of Mir-1, Mir-133a and Mir-133b were significantly or further significantly down-regulated relevant to the model group (P<0.05). +lncRNA target 31532132 hsa-mir-133b Muscular Atrophy Following EA intervention, the decreased levels of the ratio of wet weight and CSA of the gastrocnemius muscle were significantly suppressed (P<0.01), suggesting an inhibition of the skeletal muscle atrophy, and the expression levels of Pax7 and HDAC4 mRNAs were notably up-regulated (P<0.05), and those of Mir-1, Mir-133a and Mir-133b were significantly or further significantly down-regulated relevant to the model group (P<0.05). +lncRNA target 31532132 hsa-mir-1 Muscular Atrophy Following EA intervention, the decreased levels of the ratio of wet weight and CSA of the gastrocnemius muscle were significantly suppressed (P<0.01), suggesting an inhibition of the skeletal muscle atrophy, and the expression levels of Pax7 and HDAC4 mRNAs were notably up-regulated (P<0.05), and those of Mir-1, Mir-133a and Mir-133b were significantly or further significantly down-regulated relevant to the model group (P<0.05). +circulation_biomarker_diagnosis_ns 31532098 hsa-mir-100 Osteoporosis CONCLUSIONS: miR-100 was abnormally increased in the plasma of osteoporotic patients, suggesting that circulating miR-100 could serve as potential biomarker for the diagnosis and treatment osteoporosis. +circulation_biomarker_diagnosis_up 31532085 hsa-mir-451 Ischemic Stroke CONCLUSIONS: There is a significant correlation between the expression level of miR-451 in peripheral blood and the occurrence of ischemic stroke. +other 31531958 hsa-mir-155 Obesity RESULTS: Abundance of miR-155 and miR-210 was increased in ATM of participants with obesity by 6.7-fold and 2.9-fold (P = 0.002 and P = 0.013, respectively). CONCLUSIONS: Adipose tissue miRNAs are influenced in a cell type-specific fashion by obesity, with macrophage miR-155 potentially impacting neighboring adipocytes. +lncRNA target 31531526 hsa-mir-9 Carcinoma, Hepatocellular Moreover, MEG3 over-expression promoted cell apoptosis and growth inhibition in HCC cells through sponging miR +transcription factor target 31531524 hsa-mir-1224 Neuralgia Moreover, miR-1224 agomir significantly alleviated SNI-induced neuropathic pain. +other 31531311 hsa-mir-451 Endometriosis Thus, miR-451 is a novel biomarker for EMs. +circulation_biomarker_diagnosis_up 31531307 hsa-mir-122 Non-alcoholic Fatty Liver Disease CONCLUSION: Circulating miRNAs, especially miR-122, might be promising diagnostic biomarkers for NAFLD with high-accuracy, and more large-sample studies are required to support the above findings in the future. +lncRNA target 31530937 hsa-mir-370 Carcinoma, Hepatocellular Moreover, miR-370 exerted antitumor effect on HCC development through suppression of the MAPK/JNK signaling pathway by targeting BEX2. +other 31530272 hsa-mir-141 Ovarian Neoplasms CONCLUSION: According to our analysis, up-regulation of miR-141 and down-regulation of miR-205 and miR-125b have a central role in transforming endometriosis to ovarian cancer. +other 31530272 hsa-mir-205 Endometriosis CONCLUSION: According to our analysis, up-regulation of miR-141 and down-regulation of miR-205 and miR-125b have a central role in transforming endometriosis to ovarian cancer. +other 31530272 hsa-mir-141 Endometriosis CONCLUSION: According to our analysis, up-regulation of miR-141 and down-regulation of miR-205 and miR-125b have a central role in transforming endometriosis to ovarian cancer. +other 31530272 hsa-mir-125b Endometriosis CONCLUSION: According to our analysis, up-regulation of miR-141 and down-regulation of miR-205 and miR-125b have a central role in transforming endometriosis to ovarian cancer. +other 31530272 hsa-mir-125b Ovarian Neoplasms CONCLUSION: According to our analysis, up-regulation of miR-141 and down-regulation of miR-205 and miR-125b have a central role in transforming endometriosis to ovarian cancer. +other 31530272 hsa-mir-205 Ovarian Neoplasms CONCLUSION: According to our analysis, up-regulation of miR-141 and down-regulation of miR-205 and miR-125b have a central role in transforming endometriosis to ovarian cancer. +lncRNA target 31530094 hsa-mir-9 Uterine Cervical Neoplasms In conclusion, we found that hexokinase 2 serves a carcinogenic role in cervical cancer through the miR5p/hexokinase 2/AKT pathway, which serves as the basis for potential therapeutic targets and prognostic indicators. +lncRNA target 31529206 hsa-mir-519 Esophageal Squamous Cell Carcinoma CONCLUSION: These observations elucidated that upregulated miR-519 is closely correlated with the radiosensitivity of ESCC cells, which may contribute to finding a new promising target for improving the efficiency of radiotherapy in patients with ESCC. +other 31529118 hsa-mir-21 Corneal Neovascularization PURPOSE: Subconjunctival injection of antagomir-21 attenuates the progression of corneal neovascularization. +other 31528810 hsa-mir-1254 Influenza, Human Herein, we identified two miRNAs (miR-181c-5p and miR-1254) as biomarkers for detection of pandemic influenza A H1N1 virus infection and proposed the catalytic hairpin assembly-based in vitro diagnostic (CIVD) system for a highly sensitive diagnosis; this system is composed of two sets of cascade hairpin probes enabling to detect miR-181c-5p and miR-1254. +other 31528810 hsa-mir-181c Influenza, Human Herein, we identified two miRNAs (miR-181c-5p and miR-1254) as biomarkers for detection of pandemic influenza A H1N1 virus infection and proposed the catalytic hairpin assembly-based in vitro diagnostic (CIVD) system for a highly sensitive diagnosis; this system is composed of two sets of cascade hairpin probes enabling to detect miR-181c-5p and miR-1254. +lncRNA target 31528235 hsa-mir-486 Breast Neoplasms induced EMT of breast cancer cells via the Dock1/NF-kappaB/Snail signaling pathway. +lncRNA target 31528224 hsa-mir-197 Colorectal Neoplasms Taken together, our study suggests that TUG1 mediates 5-Fu resistance in CRC via miR +lncRNA target 31528122 hsa-mir-195 Adenocarcinoma of Lung Moreover, the over-expression of miR-195, or the silencing of LINC00485 enhanced the sensitivity of LAC cells to cisplatin, thereby promoting the apoptosis of LAC cells while suppressing the proliferation. +other 31527804 hsa-mir-146b Hepatitis C In conclusion, the reduction of miR146b-5p in monocytes and T cells could contribute to the immunopathogenesis of hepatitis C virus infection. +genetics_knock down_promote 31527306 hsa-mir-125a Carcinoma, Hepatocellular miR-125a-5p overexpression inhibited HCC cell proliferation and induced apoptosis in vitro and in vivo, while miR-125a-5p knockdown had the opposite effects. +lncRNA target 31526851 hsa-mir-101 Neuralgia In conclusion, miR-101 had neuropathic pain-attenuating activity through targeting mTOR. +lncRNA target 31526851 hsa-mir-101 Brain Injury, Chronic In conclusion, miR-101 had neuropathic pain-attenuating activity through targeting mTOR. +lncRNA target 31526439 hsa-mir-200b Breast Neoplasms Our results reveal that HEIH may contribute to breast cancer development via modulation of microRNA-200b/axis and inducing the activation of Wnt/beta-catenin pathway. +other 31526393 hsa-mir-126 Osteoarthritis METHODS: The expression levels of and correlation between DNM3OS and miR-126 that derived from OA and non-OA tissues were determined by quantitative real time (qRT)-PCR and Spearman's correlation analysis. Decreased expression of DNM3OS was negatively correlated with miR-126 in OA patients. +circulation_biomarker_diagnosis_ns 31526292 hsa-mir-27a Diabetes Mellitus, Type 2 Moreover, the levels of miR-27a/b increased in the serum of patients with type 2 diabetes. +circulation_biomarker_diagnosis_ns 31526292 hsa-mir-27b Diabetes Mellitus, Type 2 Moreover, the levels of miR-27a/b increased in the serum of patients with type 2 diabetes. +genetics_overexpression_suppress 31526187 hsa-mir-142 Melanoma Finally, the melanoma stage-related overexpressed miR +genetics_overexpression_suppress 31526187 hsa-mir-550a Melanoma Finally, the melanoma stage-related overexpressed miR +genetics_overexpression_suppress 31526187 hsa-mir-1201 Melanoma Finally, the melanoma stage-related overexpressed miR +genetics_overexpression_suppress 31526187 hsa-mir-550 Melanoma Finally, the melanoma stage-related overexpressed miR +genetics_overexpression_suppress 31526187 hsa-mir-1826 Melanoma Finally, the melanoma stage-related overexpressed miR +other 31526129 hsa-mir-130a Lung Neoplasms Our results identified miR-130a-3p which was down-regulated in S30 cells as well as A549 and H1299 lung cancer cell lines. Our findings demonstrate that upregulated miR-130a-3p was associated with reduced SPOCK1 expression in transformed S30 as well as lung cancer A549 and H1299 cell lines indicating that cigarette transformed cells behave similar to lung cancer cells and this process involves diminished lung cancer cells migration. +other 31526125 hsa-mir-425 Skin Neoplasms 5p were differentially expressed in canine malignant melanoma and healthy FFPE samples, suggesting that they may play a role in canine malignant melanoma pathogenesis. +other 31526125 hsa-mir-365 Skin Neoplasms 5p were differentially expressed in canine malignant melanoma and healthy FFPE samples, suggesting that they may play a role in canine malignant melanoma pathogenesis. +other 31526125 hsa-mir-146a Skin Neoplasms 5p were differentially expressed in canine malignant melanoma and healthy FFPE samples, suggesting that they may play a role in canine malignant melanoma pathogenesis. +other 31526125 hsa-mir-145 Skin Neoplasms Cutaneous canine malignant melanoma showed a decrease of the expression level of miR-145 and miR-365 and an increase of miR-146a and miR5p compared to control samples. +lncRNA target 31526099 hsa-mir-204 Stomach Neoplasms CONCLUSION: Zinc finger protein 521 can arrest the apoptosis and enhance the proliferation, migration, and invasion of gastric cancer cells via regulating microRNA +genetics_overexpression_suppress 31526052 hsa-mir-204 Ovarian Neoplasms 5p overexpression represses OC cell proliferation. +other 31525899 hsa-mir-133a Myocardial Infarction By utilizing the affinity discrepancy of the CNN to single-stranded and double-stranded nucleic acids, a label-free and signal-on ECL biosensor was constructed for the determination of microRNA-133a (miR-133a), a potential biomarker of acute myocardial infarction. +genetics_knock down_promote 31525734 hsa-mir-376a Osteosarcoma Resumption of DKK1 expression reversed the tumor-suppressive activities of miR-376a overexpression in OS cells. +other 31525642 hsa-mir-223 Squamous Cell Carcinoma of Head and Neck In mechanism, our data indicated that hsa_circ_0042666 could competitively bind to miR-223 as a miRNA sponge to regulate TGFBR3 expression in LSCC progression. Altogether, these findings elucidated that hsa_circ_0042666 regulated LSCC cells proliferation and invasion by miR-223/TGFBR3 axis, which might provide a therapeutic strategy for the treatment of LSCC. +circulation_biomarker_diagnosis_up 31525485 hsa-mir-145 Cerebral Hemorrhage, Spontaneous CONCLUSION: Our results have shown that measurement of circulating miR-181b, miR-223, miR-155, and miR-145 in plasma samples could serve as a potential noninvasive tool for ICH detection. +lncRNA target 31525429 hsa-mir-299 Uterine Cervical Neoplasms SIGNIFICANCE: In conclusion, our results revealed that RHPN1-AS1 promoted cervical cancer progression via targeting miR +genetics_overexpression_promote 31525340 hsa-mir-133b Colorectal Neoplasms Additionally, miR-133b overexpression reduces CRC stemness and overrides chemoresistance to 5-Fluorouracil (5-FU) and oxaliplatin (OXP), indicating a negative role of miR-133b in regulating CRC stemness and chemoresistance. +other 31524946 hsa-mir-194 Stomach Neoplasms pylori (+) GC patients for hsa-miR-194 were 4.24- and 3.83-fold higher, respectively, whereas the hsa-miR-145 expression levels were downregulated 0.33-fold and 0.43-fold, respectively, in the same group. +other 31524946 hsa-mir-145 Stomach Neoplasms pylori (+) GC patients for hsa-miR-194 were 4.24- and 3.83-fold higher, respectively, whereas the hsa-miR-145 expression levels were downregulated 0.33-fold and 0.43-fold, respectively, in the same group. +genetics_GWAS 31524549 hsa-mir-130b Lung Neoplasms It was also of interest to examine the seven sites on the promoter region of miR-130b encoding gene in lung cancer patients and then compare methylation at these loci with miR-130b expression. +lncRNA target 31524269 hsa-mir-218 Glioblastoma The results of functional experiments demonstrated that VAT1 exhibited high expression levels in GBM, which could be inhibited by microRNA218. +lncRNA target 31524268 hsa-mir-17 Uterine Cervical Neoplasms The present study investigated the underlying regulatory network involved in the differential expression of metastasis associated lung adenocarcinoma transcript 1 (MALAT1) long noncoding (lnc)RNA, microRNA175p (miR175p) and frizzled class receptor 2 (FZD2) mRNA under the influence of Casiopeina IIgly (CasIIgly) via the Wnt signaling pathway in cervical carcinoma (CC). +genetics_overexpression_promote 31524259 hsa-mir-185 Osteosarcoma Overexpressed miR185 downregulated the mRNA and protein levels of HK2 in OS cells. +transcription factor target 31524250 hsa-mir-34a Arthritis, Rheumatoid The results of the present study indicated that miR34a3p may be considered a promising therapeutic target for RA through inhibiting FLS proliferation and suppressing the production of proinflammatory cytokines and MMPs. +genetics_overexpression_promote 31524231 hsa-mir-592 Thyroid Neoplasms Furthermore, ectopic NOVA1 expression may effectively abolish the tumorsuppressing effects of miR592 overexpression in thyroid cancer cells. +lncRNA target 31524148 hsa-mir-511 Osteosarcoma Further study showed that miR-511 mimic inhibits the development of osteosarcoma MG63 cell, including proliferation and invasion. +lncRNA target 31524147 hsa-mir-652 Stomach Neoplasms CONCLUSION MiR-652 functions as an oncogene in GC and promotes tumor progression via targeting RORA. +genetics_overexpression_promote 31524145 hsa-mir-935 Colorectal Neoplasms In addition, overexpression of miR-935 in CRC cells promoted cell proliferation, migration, and invasion, whereas inhibition of miR-935 suppressed cell proliferation, migration, and invasion. +genetics_overexpression_promote 31524144 hsa-mir-181d Stomach Neoplasms Overexpression of miR-181d significantly promoted the NCI-N87 and MGC-803 cells proliferation, migration and invasion (all P< 0.05). +other 31524101 hsa-mir-182 Liver Neoplasms It is of interest that utilization of liver cancer tissues from the Cancer Genome Atlas (TCGA) database also demonstrated that upregulated miR5p expression and reduced Cited2 mRNA expression was detected suggesting that TCE-induced hepatocarcinogenesis involved processes similar to those in humans. +genetics_overexpression_promote 31524101 hsa-mir-182 Carcinogenesis 5p overexpression. +genetics_GWAS 31523393 hsa-mir-217 Pancreatic Carcinoma Initially we found that miR-217, which has been shown to directly regulate KRAS expression, is downregulated in our PDAC samples, thus we tested the benefits of anti-miR-21, miR-217 mimic or siKRAS loaded into the tumor-penetrating nanoparticles (TPN) that we had previously shown to potently target the largely impenetrable PDAC tumors, and found an enhanced anti-tumoral response upon dual treatments in KRAS-mutated PDAC models. +other 31523393 hsa-mir-21 Pancreatic Carcinoma miR5p oncomiR) play key roles in Pancreatic Ductal Adenocarcinoma (PDAC), leading to rapid progression of the disease. +other 31523391 hsa-mir-125a Leukemia, Myeloid, Acute Ectopic expression of miR-125a-5p also promoted granulocytic differentiation in human acute promyelocytic leukemia NB4 cells, as well as in naive human primary CD34(+)-hematopoietic progenitor/stem cells. +lncRNA target 31523191 hsa-mir-671 Esophageal Squamous Cell Carcinoma Therefore, suppressing FGFR2 and enhancing miR +exosome 31523188 hsa-mir-21 Femur Head Necrosis In this study, we hypothesised that exosomes reduce osteocyte apoptosis in rat GIONFH via the miRPTEN-AKT signalling pathway. +other 31523056 hsa-mir-340 Cholangiocarcinoma CDX1-COMMD6 transcriptional network in cholangiocarcinoma. +other 31523056 hsa-mir-218 Squamous Cell Carcinoma of Head and Neck CDX1-COMMD6 transcriptional network in cholangiocarcinoma. +other 31523056 hsa-mir-218 Cholangiocarcinoma CDX1-COMMD6 transcriptional network in cholangiocarcinoma. +other 31523056 hsa-mir-340 Squamous Cell Carcinoma of Head and Neck CDX1-COMMD6 transcriptional network in cholangiocarcinoma. +lncRNA target 31522868 hsa-mir-137 Schizophrenia In this article we overview select risk genes identified through recent genome-wide association studies of SCZ including AKT3, miR-137, DRD2, and AKT1 itself. +other 31522616 hsa-mir-150 Adenocarcinoma of Lung Collectively, we conclude that the novel FAM83A-AS1/miR5p/MMP14 axis regulates LUAD progression, suggesting an innovative therapeutic strategy for this cancer. +lncRNA target 31522595 hsa-mir-141 Glioblastoma Here, it is shown that miR-141 is downregulated in glioblastoma cell lines and tissues and may exert its biological function via directly targeting myelin transcription factor 1-like (MYT1L). +genetics_knock down_promote 31522588 hsa-mir-7 Carcinoma, Hepatocellular Abbreviations: HCC: hepatocellular carcinoma; circRNAs: circular RNAs; miRNA/miR: microRNA; miR-7: microRNA-7; FAK: focal adhesion kinase; KLF-4: kruppel like factor 4; DKK1: dickkopf WNT signaling pathway inhibitor 1; ccRCC: clear cell renal cell carcinoma; PI3K: phosphoinositide 3-kinase; Ct: comparative threshold cycle; RPMI: Roswell Park Memorial Institute; FBS: fetal bovine serum; RT: reverse transcription; qPCR: quantitative polymerase chain reaction; RIPA: radioimmunoprecipitation assay; SDS-PAGE: sodium dodecyl sulfate-polyacrylamide gel electrophoresis; PVDF: polyvinylidene difluoride; GAPDH: glyceraldehyde +other 31522444 hsa-mir-106a Asthma MiR-106a and miR-126 had a positive correlation in CD8+ cells of asthmatic patients. +other 31522444 hsa-mir-126 Asthma MiR-106a and miR-126 had a positive correlation in CD8+ cells of asthmatic patients. +lncRNA target 31521891 hsa-mir-143 Carcinoma, Pancreatic Ductal 3p may suppress tumorigenesis in PDAC by targeting KRAS. +genetics_knock down_promote 31521692 hsa-mir-137 Pancreatic Carcinoma Taken together, knockdown of circ-LDLRAD3 repressed the proliferation, migration and invasion of pancreatic cancer cells through miR +lncRNA target 31520995 hsa-mir-27a Cartilage Diseases Subsequently, the expression levels of miR-27a were validated in the articular tissues of OA patients and IL-1beta-stimulated chondrocytes. Our findings suggest that miR-27a may be considered as a potential therapeutic target in the treatment of OA. +other 31520606 hsa-mir-23c Diabetic Foot Further, the tissue-specific expressions of miR-23a and miR-23b were found to be low whereas miR-23c was increased in patients with infected DFU. +other 31520606 hsa-mir-23b Diabetic Foot Further, the tissue-specific expressions of miR-23a and miR-23b were found to be low whereas miR-23c was increased in patients with infected DFU. +other 31520606 hsa-mir-23a Diabetic Foot Further, the tissue-specific expressions of miR-23a and miR-23b were found to be low whereas miR-23c was increased in patients with infected DFU. +lncRNA target 31520555 hsa-mir-590 Carcinoma, Non-Small-Cell Lung 5p functions as a tumor suppressor in NSCLC through regulating the STAT3 pathway, and may serve as a useful biomarker for the diagnosis/prognosis of NSCLC, and as a potential therapeutic target for the treatment of NSCLC. +circulation_biomarker_diagnosis_up 31520466 hsa-mir-361 Ovarian Neoplasms There were associations of serum lncRNA RP5-837J1.2 with the affected ovary and worse International Federation of Gynecology and Obstetrics staging; associations of miR +lncRNA target 31520422 hsa-mir-218 Pulmonary Eosinophilia 5p plays a protective role in eosinophilic airway inflammation via targeting CTNND2, a novel catenin in asthma, and suppressing chemokine CCL26 expression. +lncRNA target 31520422 hsa-mir-218 Asthma 5p plays a protective role in eosinophilic airway inflammation via targeting CTNND2, a novel catenin in asthma, and suppressing chemokine CCL26 expression. +circulation_biomarker_diagnosis_ns 31519959 hsa-mir-122 Obesity These results reveal the serum exosomal miR5p level is negatively associated with BAT activity independently of obesity. +transcription factor target 31519321 hsa-mir-25 Carcinoma, Hepatocellular 3p/DPAGT1 axis dysregulation in supporting HBV HCC chemoresistance. +genetics_GWAS 31518872 hsa-mir-96 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Additionally, we found that the novel histone deacetylase drug chidamide and the DNA methyltransferase inhibitor decitabine could restore the low expression of miR-96 in CML cells, and there were two abnormal hypermethylated sites in the promoter region of miR-96 in CML, suggesting that its low expression might be at least partially regulated by epigenetic mechanisms. +lncRNA target 31518563 hsa-mir-125b psoriasis 1 Our study suggested that the upregulation of miR-125b-5p or miR-181b-5p inhibited HEKs proliferation at least partly by targeting Akt3, providing novel mechanisms of miRNAs involved in psoriasis. +lncRNA target 31518563 hsa-mir-181b psoriasis 1 Our study suggested that the upregulation of miR-125b-5p or miR-181b-5p inhibited HEKs proliferation at least partly by targeting Akt3, providing novel mechanisms of miRNAs involved in psoriasis. +genetics_knock down_promote 31518383 hsa-mir-129 Pancreatic Carcinoma 5p overexpression suppressed proliferation, migration and invasion, and induced apoptosis of PC cells, whereas miR +genetics_overexpression_promote 31518341 hsa-mir-194 Pancreatitis Overexpression of MALAT1 or YAP1 can increase the levels of IL-6 and TNF-alpha secreted by AR42J cells, while miR-194 dramatically counteracts this enhancement effect. +lncRNA target 31517861 hsa-mir-483 Echinococcosis, Hepatic Target genes of differentially expressed miRNAs were predicted using Targetscan, PITA and microRNAorg database, and the overlapped predicted target genes were analyzed by GO and KEGG.The hsa-miR +lncRNA target 31517857 hsa-mir-92b Hepatitis B, Chronic Moreover, in vitro experiments indicated that inhibition of miR-92b-3p increased lipid droplet formation in LX2 cells.Aberrant expression of miRNAs has been observed in urine of CHB patients. +genetics_overexpression_promote 31517731 hsa-mir-342 Ovarian Neoplasms Furthermore, overexpression of FOXQ1 could partially rescue inhibitory effect of miR +circulation_biomarker_diagnosis_up 31517622 hsa-mir-190b Insulin Resistance It is possible that transcription factor NFX1 and miR-190b participate in downregulation of HLA-DRA gene expression in the blood of obese adolescents with insulin resistance. +circulation_biomarker_diagnosis_up 31517622 hsa-mir-190b Obesity It is possible that transcription factor NFX1 and miR-190b participate in downregulation of HLA-DRA gene expression in the blood of obese adolescents with insulin resistance. +lncRNA target 31517391 hsa-mir-7 Stomach Neoplasms Hence, these data demonstrated that miR5p represses GCSC invasion through inhibition of Smo and Hes1, which provides a potential therapeutic target of gastric cancer treatment. +lncRNA target 31516562 hsa-mir-139 Carcinoma, Pancreatic Ductal 5p may be a tumor suppressor in PDAC, which may be useful in developing promising therapies for PDAC. +lncRNA target 31516391 hsa-mir-26a Colorectal Neoplasms CONCLUSION: SNHG6 may promote chemoresistance through ULK1-induced autophagy by sponging miR-26a-5p in CRC cells. +lncRNA target 31516388 hsa-mir-200c Carcinoma, Renal Cell CONCLUSION: Collectively, this study highlights that upregulated miR-200c-3p inhibits expression of SOX2, thereby inhibiting development of RCC cells via modulating the Wnt/beta-catenin signaling pathway activation. +other 31516387 hsa-mir-145 Neoplasm Metastasis These in vitro observations were validated in a representative set of nodal positive tumors of stage 3 and 4 depicting higher miR-145 expression as compared to early stages. +genetics_overexpression_promote 31515938 hsa-mir-195 Stomach Neoplasms Overexpression of miR-195 inhibited proliferation and promoted apoptosis in GC cells. +transcription factor target 31515718 hsa-mir-200a Liver Diseases Therefore, the present study indicates that antagomir-200a-3p is related to ATRA-induced hepatic differentiation of HPCs through regulating cell autophagy, supporting the possible use of ATRA as a key inducer in HPC-based therapy of liver diseases. +other 31515600 hsa-mir-27b Colorectal Neoplasms Our laboratory has previously reported that miR27b can regulate CYP1B1 expression in colorectal cells, here we have investigated if this mechanism is working in mammary cell models, MCF-7 and MDA-MB-231 cells. +transcription factor target 31515517 hsa-mir-155 Alzheimer Disease Through screening, we selected miR-106b, miR-146b, miR-181a, miR-200a, miR-34a, miR-124b, miR-153, miR-155, Abeta(1-42) monomer (mAbeta), Abeta(1-42) oligomer (oAbeta), UCHL1, NLRP3, Tau, STAT3, SORL1, Clusterin, APOE3, APOE4, Nogo-A, IL-13, and Visfatin to serve as AD- and inflammation-related markers. +transcription factor target 31515517 hsa-mir-153 Alzheimer Disease Through screening, we selected miR-106b, miR-146b, miR-181a, miR-200a, miR-34a, miR-124b, miR-153, miR-155, Abeta(1-42) monomer (mAbeta), Abeta(1-42) oligomer (oAbeta), UCHL1, NLRP3, Tau, STAT3, SORL1, Clusterin, APOE3, APOE4, Nogo-A, IL-13, and Visfatin to serve as AD- and inflammation-related markers. +transcription factor target 31515517 hsa-mir-181a Alzheimer Disease Through screening, we selected miR-106b, miR-146b, miR-181a, miR-200a, miR-34a, miR-124b, miR-153, miR-155, Abeta(1-42) monomer (mAbeta), Abeta(1-42) oligomer (oAbeta), UCHL1, NLRP3, Tau, STAT3, SORL1, Clusterin, APOE3, APOE4, Nogo-A, IL-13, and Visfatin to serve as AD- and inflammation-related markers. +transcription factor target 31515517 hsa-mir-106b Alzheimer Disease Through screening, we selected miR-106b, miR-146b, miR-181a, miR-200a, miR-34a, miR-124b, miR-153, miR-155, Abeta(1-42) monomer (mAbeta), Abeta(1-42) oligomer (oAbeta), UCHL1, NLRP3, Tau, STAT3, SORL1, Clusterin, APOE3, APOE4, Nogo-A, IL-13, and Visfatin to serve as AD- and inflammation-related markers. +transcription factor target 31515517 hsa-mir-34a Alzheimer Disease Through screening, we selected miR-106b, miR-146b, miR-181a, miR-200a, miR-34a, miR-124b, miR-153, miR-155, Abeta(1-42) monomer (mAbeta), Abeta(1-42) oligomer (oAbeta), UCHL1, NLRP3, Tau, STAT3, SORL1, Clusterin, APOE3, APOE4, Nogo-A, IL-13, and Visfatin to serve as AD- and inflammation-related markers. +transcription factor target 31515517 hsa-mir-146b Alzheimer Disease Through screening, we selected miR-106b, miR-146b, miR-181a, miR-200a, miR-34a, miR-124b, miR-153, miR-155, Abeta(1-42) monomer (mAbeta), Abeta(1-42) oligomer (oAbeta), UCHL1, NLRP3, Tau, STAT3, SORL1, Clusterin, APOE3, APOE4, Nogo-A, IL-13, and Visfatin to serve as AD- and inflammation-related markers. +transcription factor target 31515517 hsa-mir-124b Alzheimer Disease Through screening, we selected miR-106b, miR-146b, miR-181a, miR-200a, miR-34a, miR-124b, miR-153, miR-155, Abeta(1-42) monomer (mAbeta), Abeta(1-42) oligomer (oAbeta), UCHL1, NLRP3, Tau, STAT3, SORL1, Clusterin, APOE3, APOE4, Nogo-A, IL-13, and Visfatin to serve as AD- and inflammation-related markers. +transcription factor target 31515517 hsa-mir-200a Alzheimer Disease Through screening, we selected miR-106b, miR-146b, miR-181a, miR-200a, miR-34a, miR-124b, miR-153, miR-155, Abeta(1-42) monomer (mAbeta), Abeta(1-42) oligomer (oAbeta), UCHL1, NLRP3, Tau, STAT3, SORL1, Clusterin, APOE3, APOE4, Nogo-A, IL-13, and Visfatin to serve as AD- and inflammation-related markers. +lncRNA target 31515477 hsa-mir-17 Polycystic Kidney Diseases Here we report the discovery and characterization of RGLS4326, a first-in-class, short oligonucleotide inhibitor of microRNA-17 (miR-17), as a potential treatment for ADPKD. +lncRNA target 31515469 hsa-mir-20a Colorectal Neoplasms Previous studies have shown that miR-320a is downregulated in colorectal cancer and targets the small GTPase Rac1, leading to a reduction in noncanonical WNT signaling and EMT, thereby inhibiting tumor metastasis and invasion. +genetics_knock down_promote 31515467 hsa-mir-203a Colorectal Neoplasms The use of anti-miR-203a-3p.1 reversed the inhibitory effects of circ_0079993 knockdown on CRC cell proliferation. +other 31515296 hsa-mir-188 Leukemia, Myelogenous, Chronic, BCR-ABL Positive 5p/PTEN axis and thus repressing the PI3K/AKT signaling. +other 31514456 hsa-mir-205 Squamous Cell Carcinoma of Head and Neck High miR5p levels in the peritumoral tissues might be relevant for the early detection of minimal residual disease and pre-cancer molecular alterations involved in tumor development. +lncRNA target 31514295 hsa-mir-143 Adenocarcinoma of Lung 5p and its target genes were involved in the molecular pathogenesis of LUAD. +genetics_knock down_promote 31514083 hsa-let-7 Melanoma Knockdown of miR-let-7a/f diminished the effects of SLE on CCR7 signaling in, and invasion of, melanoma cells. +genetics_knock down_promote 31514083 hsa-let-7f Melanoma Knockdown of miR-let-7a/f diminished the effects of SLE on CCR7 signaling in, and invasion of, melanoma cells. +genetics_knock down_promote 31514083 hsa-let-7a Melanoma Knockdown of miR-let-7a/f diminished the effects of SLE on CCR7 signaling in, and invasion of, melanoma cells. +transcription factor target 31514072 hsa-mir-338 Carcinoma, Hepatocellular miR-338 was upregulated in HCC cells treated with (125)I irradiation, which was a negative correlation with tumor size, tumor metastasis, and tumor development. CONCLUSION: (125)I irradiation upregulated the suppression of miR-338 on PFKL to downregulate the Warburg effect and anti-tumorigenesis in HCC and provided a new potential strategy for HCC clinical treatment. +genetics_overexpression_promote 31514071 hsa-mir-1181 Carcinoma, Hepatocellular Here, we showed that miR-1181 was significantly overexpressed in HCC tissues when compared with tumor-adjacent normal ones or normal liver tissues from donated organ, and that inhibition of miR-1181 could repress the growth of HCC cells. +other 31514066 hsa-mir-221 Carcinoma, Renal Cell 5p might not only be an oncogene in ccRCC cells but also might be an independent prognosis factor of ccRCC. +other 31513959 hsa-mir-21 Breast Neoplasms MicroRNA-21 (miRNA-21) is a promising diagnostic biomarker for breast cancer screening and disease progression. The proposed ECL biosensor was successfully applied to detect miRNA-21 in total RNA samples extracted from human breast cancer cells, and it showed great potential for early cancer diagnosis based on miRNA as a biomarker. +transcription factor target 31513891 hsa-mir-1307 Colonic Neoplasms 3p inhibited activation of Wnt3a/-catenin signaling through targeting downregulation of ISM1, thereby inhibited proliferation and promote apoptosis of COAD cells. +other 31513704 hsa-mir-29a Graft Occlusion, Vascular miR-29a-3p may have potential clinical implications in the pathogenesis of remodeling of vein graft restenosis. +other 31513595 hsa-mir-148a Carcinoma, Hepatocellular 5p and miR-148a-3p were associated with gross VI and poor survival of patients after hepatic resection for HCC. +other 31513595 hsa-mir-100 Carcinoma, Hepatocellular 5p and miR-148a-3p were associated with gross VI and poor survival of patients after hepatic resection for HCC. +other 31513548 hsa-mir-486 Hypoplastic Left Heart Syndrome The right ventricles (RVs) of patients with HLHS experienced increased stretch and had a trend toward higher miR-486 levels. +other 31513434 hsa-mir-145 Endometrial Neoplasms 5p might be involved in the pathogenesis of endometrial cancer and could act as prognostic biomarkers for endometrial cancer patients. +other 31513434 hsa-mir-449a Endometrial Neoplasms 5p might be involved in the pathogenesis of endometrial cancer and could act as prognostic biomarkers for endometrial cancer patients. +lncRNA target 31513352 hsa-mir-613 Pancreatic Carcinoma Mechanistic studies revealed that miR-613 was targeted by SNHG14, and Annexin A2 (ANXA2) was targeted and inversely regulated by miR-613 in pancreatic cancer cells. +lncRNA target 31513316 hsa-mir-19a Ovarian Neoplasms These results showed that miR-19a-3p enhances the oncogenesis of ovarian cancer through inhibition of IGFBP-3 expression, and which can be inhibited by NF-kappaB, suggesting an NF-kappaB/miR-19a-3p/IGFBP-3 pathway in the oncogenesis of ovarian cancer, which expands our understanding of ovarian cancer and they may contribute to the development of new diagnosis and treatment of ovarian cancer. +genetics_GWAS 31513017 hsa-mir-142 Glioma CONCLUSION: Our study provided the first evidence for the impact of rs1582417, rs17057846, rs2431689, rs2961920, rs58747524, and rs7727115 polymorphisms in MIR3142HG on the susceptibility to and/or prognosis of glioma in the Chinese Han population. +lncRNA target 31512829 hsa-mir-107 Squamous Cell Carcinoma of Head and Neck METHODS: The expression levels of lncRNA H19, miR-107, and cyclin-dependent kinase 6 (CDK6) in the immortalized oral epithelial cell line HIOEC and the oral cancer cell line CAL27 were detected by real-time quantitative polymerase chain reaction. It can regulate the invasion and migration of oral cancer cells by targeting the miR-107/CDK6 signaling axis. +lncRNA target 31512793 hsa-mir-193a Colorectal Neoplasms Therefore, it could be concluded miR-193a inactivates cell migration via suppression of metastasis pathways in CRC and through downregulation of c-Myc, acts as a negative regulator of cell cycle and growth. +lncRNA target 31512460 hsa-mir-221 Peripheral Nerve Injuries OBJECTIVE: To study the expressions of microRNA-221 (miR-221) and the protein of phosphatase and tension protein homologue (PTEN) in the proximal and distal stumps after sciatic nerve injury in rats and their correlation with the repair of peripheral nerve injury, so as to provide a new target for clinical diagnosis of peripheral nerve injury. +other 31512372 hsa-let-7c Colorectal Neoplasms The ROC analysis revealed that miRNAs (let-7c, 21, 26a and 146a) can effectively discriminate between CRC patients and the controls. The current data suggest that miRNAs (let-7c, 21, 26a, 146a) could play an important role in CRC development and they can be used as diagnostic biomarkers for CRC. +lncRNA target 31511959 hsa-mir-17 Ossification of the posterior longitudinal ligament of the spine Together, this study was the first to determine that XIST gene inhibition plays an important role in the occurrence of cervical OPLL, through the mechanism of regulation of miR5P/AHNAK/BMP2 signaling pathway. +lncRNA target 31511959 hsa-mir-17 Ossification of Posterior Longitudinal Ligament Together, this study was the first to determine that XIST gene inhibition plays an important role in the occurrence of cervical OPLL, through the mechanism of regulation of miR +other 31511910 hsa-mir-223 Tuberous Sclerosis 3p in epileptogenic brain tissue resected for the treatment of intractable epilepsy in children with tuberous sclerosis complex (TSC). +other 31511910 hsa-mir-142 Tuberous Sclerosis 3p in epileptogenic brain tissue resected for the treatment of intractable epilepsy in children with tuberous sclerosis complex (TSC). +genetics_overexpression_suppress 31511497 hsa-mir-146a Cardiotoxicity The cardiotoxicity was inhibited by overexpressed miR-146a and was more severe when miR-146a was downgraded. +lncRNA target 31511208 hsa-mir-18 Shock, Hemorrhagic CONCLUSIONS: Inhibition of miR-186 protects vascular endothelial cells against hypoxic injuries by promoting HIF-alpha expression to lessen mitochondrial damage, suggesting the possibility of targeted miR-186 interference for treatment of hemorrhagic shock. +lncRNA target 31511208 hsa-mir-186 Shock, Hemorrhagic CONCLUSIONS: Inhibition of miR-186 protects vascular endothelial cells against hypoxic injuries by promoting HIF-alpha expression to lessen mitochondrial damage, suggesting the possibility of targeted miR-186 interference for treatment of hemorrhagic shock. +lncRNA target 31511208 hsa-mir-18 Hypoxia, Brain CONCLUSIONS: Inhibition of miR-186 protects vascular endothelial cells against hypoxic injuries by promoting HIF-alpha expression to lessen mitochondrial damage, suggesting the possibility of targeted miR-186 interference for treatment of hemorrhagic shock. +lncRNA target 31511208 hsa-mir-186 Hypoxia, Brain CONCLUSIONS: Inhibition of miR-186 protects vascular endothelial cells against hypoxic injuries by promoting HIF-alpha expression to lessen mitochondrial damage, suggesting the possibility of targeted miR-186 interference for treatment of hemorrhagic shock. +lncRNA target 31511040 hsa-mir-30 Glioma Increasing expression of circPTN rescued the inhibition of proliferation and downregulation of SOX9/ITGA5 in glioma cells by miR +lncRNA target 31511040 hsa-mir-145 Glioma Increasing expression of circPTN rescued the inhibition of proliferation and downregulation of SOX9/ITGA5 in glioma cells by miR +lncRNA target 31510782 hsa-mir-149 Squamous Cell Carcinoma of Head and Neck Regarding the mechanism, circular matrix metalloproteinase 9 could simultaneously interact with AUF1 and miR-149 to block the inhibitory effect of AUF1 and miR-149 on matrix metalloproteinase 9 3'-untranslated region, resulting in enhanced matrix metalloproteinase 9 messenger RNA stability, thereby facilitating oral squamous cell carcinoma metastasis. +lncRNA target 31509966 hsa-mir-101 Stomach Neoplasms Finally, we evaluated EZH2 expression, a target of both miR-101 and miR-26b, which showed significant upregulation in IGCs (p-value = 0.005). +lncRNA target 31509966 hsa-mir-26b Stomach Neoplasms Finally, we evaluated EZH2 expression, a target of both miR-101 and miR-26b, which showed significant upregulation in IGCs (p-value = 0.005). +transcription factor target 31509760 hsa-mir-544a Stomach Neoplasms The up-regulation of miR-544a could be crucially involved in the GKN1 translational repression, thus suggesting its potential role as a biomarker and therapeutic target in GC patients. +other 31509760 hsa-mir-1245b Stomach Neoplasms TaqMan miRNA assay performed on gastric cancer cell lines after TSA treatment showed a stronger increase of miR-544a expression than that of miR-1245b-3p. +genetics_GWAS 31509024 hsa-mir-455 Colorectal Neoplasms The rs1252200336 locus deletion mutation (D) may impact the binding of hsa-miR +other 31508952 hsa-mir-29b Pneumonia, Mycoplasma Interestingly, PFOS (10 muM) significantly increased miR29-b (p < 0.01), which has been previously reported to be associated with PE. +transcription factor target 31508813 hsa-mir-483 Triple Negative Breast Neoplasms 3p as a tumor suppressor in TNBC and showed the possible mechanism via HDAC8. +lncRNA target 31508486 hsa-mir-195 Lung Neoplasms We and others have shown that miR-195 regulates the sensitivity of NSCLC to microtubule-targeting agents (MTAs) in vitro and in vivo and that miR-195 represses the migration and invasion of NSCLC cells in vitro. +lncRNA target 31508417 hsa-mir-455 Cartilage Diseases 3p/CCL3 plays a critical role in OA pathogenesis and suggests HOTTIP is a potential target in OA therapy. +circulation_biomarker_diagnosis_up 31508175 hsa-mir-126 Diabetes Mellitus RESULTS: The plasma levels of miR-24, miR-126, body weight, high-density lipoprotein cholesterol (HDL-c), total anti-oxidant capacity (TAC) and the systolic blood pressure significantly reduced and blood glucose, total cholesterol (TC), triglycerides (TG), very low-density lipoprotein cholesterol (VLDL-c), malondialdehyde (MDA), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and low-density lipoprotein cholesterol (LDL-c) significantly elevated among the diabetic rats compared with the control group. +circulation_biomarker_diagnosis_up 31508175 hsa-mir-24 Diabetes Mellitus RESULTS: The plasma levels of miR-24, miR-126, body weight, high-density lipoprotein cholesterol (HDL-c), total anti-oxidant capacity (TAC) and the systolic blood pressure significantly reduced and blood glucose, total cholesterol (TC), triglycerides (TG), very low-density lipoprotein cholesterol (VLDL-c), malondialdehyde (MDA), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and low-density lipoprotein cholesterol (LDL-c) significantly elevated among the diabetic rats compared with the control group. +other 31507414 hsa-mir-146a Heart Diseases Thus, miR-146a could be a useful protective agent against sunitinib-induced cardiac dysfunction. +genetics_GWAS 31507089 hsa-mir-206 Lung Neoplasms In this study, we investigated the role of miR-206 in IL6-induced gefitinib-resistant EGFR-mutated lung cancer cell lines. +transcription factor target 31506763 hsa-mir-34a Kidney Calculi Furthermore, miR-34a suppressed cell-crystals adhesion and stone formation in vivo. Based on these results, miR-34a may be a potential therapeutic target for renal stone disease. +circulation_biomarker_diagnosis_up 31506750 hsa-mir-1246 Stomach Neoplasms CONCLUSION: Circulating exosomal miR-1246 was a potential biomarker for the early diagnosis of GC. +other 31506588 hsa-mir-223 Breast Neoplasms We show that STIM1 expression is regulated post-transcriptionally by the miRNA machinery and identify miR-223 and miR-150 as regulators of STIM1 expression in the luminal non-aggressive MCF7 breast cancer cell line. +other 31506588 hsa-mir-150 Breast Neoplasms We show that STIM1 expression is regulated post-transcriptionally by the miRNA machinery and identify miR-223 and miR-150 as regulators of STIM1 expression in the luminal non-aggressive MCF7 breast cancer cell line. +genetics_knock down_promote 31506178 hsa-mir-96 Diabetes Mellitus IPGTT and IPITT results indicated that knockout of microRNA-96 led to pancreatic beta cell dysfunction under the pathological condition of T2DM. +circulation_biomarker_diagnosis_up 31506152 hsa-mir-122 Obesity CONCLUSIONS: The elevated serum miR-122 levels may be correlated with insulin resistance in obese children. +genetics_overexpression_promote 31506061 hsa-mir-206 Breast Neoplasms We showed that the overexpression of miR-206 promotes breast cancer cell invasion, migration, proliferation, and colony formation in vitro. +lncRNA target 31506038 hsa-mir-21 Lung Neoplasms Furthermore, microRNA-21 targeted cell division cycle associated 8 and then played roles in lung cancer via the process of cell division. +transcription factor target 31505424 hsa-mir-410 Arthritis, Rheumatoid 3p mimics and inhibitor into RA FLSs, and conducting CCK-8 assay, EdU staining and flow cytometry. +lncRNA target 31505165 hsa-mir-139 Carcinoma, Renal Cell 5p/TOP2A axis plays an important role in the proliferation and metastasis of ccRCC, and was expected to be a new biomarker for diagnosis, prognosis and a target for treatment of ccRCC. +genetics_knock down_promote 31505105 hsa-mir-122 Uterine Cervical Neoplasms 5p or knockdown of CDC25A inhibits the survival and induces apoptosis of cervical cancer colonies. +lncRNA target 31504797 hsa-mir-432 Glioblastoma 5p inhibitors in GBM cells. +genetics_overexpression_promote 31504670 hsa-mir-199a Glioblastoma Overexpression of SNHG9 in glioblastoma cells promoted aerobic glycolysis and cell proliferation, which could be attenuated by miR-199a-5p. +circulation_biomarker_diagnosis_ns 31504257 hsa-mir-378a Intermittent Claudication Similar elevation of miR-378a-3p was reported in the plasma of patients with intermittent claudication in comparison to healthy donors. +genetics_overexpression_promote 31503422 hsa-mir-106b Carcinoma, Hepatocellular Functionally, miR-106b-5p upregulation promoted the viability and invasion of HCC cells, while enforced RUNX3 expression reversed the oncogenic effects of miR-106b-5p overexpression. +circulation_biomarker_diagnosis_ns 31503420 hsa-mir-126a Dysautonomia, Familial Furthermore, we validated miR-21a-5p, miR-146a-5p, and miR-126a-3p as dysregulated in both murine doxycycline-induced FT and metastatic tumors, as well as in murine plasma and patient serum samples. +circulation_biomarker_diagnosis_ns 31503420 hsa-mir-126a Neoplasm Metastasis Furthermore, we validated miR-21a-5p, miR-146a-5p, and miR-126a-3p as dysregulated in both murine doxycycline-induced FT and metastatic tumors, as well as in murine plasma and patient serum samples. +circulation_biomarker_diagnosis_ns 31503420 hsa-mir-146a Neoplasm Metastasis Furthermore, we validated miR-21a-5p, miR-146a-5p, and miR-126a-3p as dysregulated in both murine doxycycline-induced FT and metastatic tumors, as well as in murine plasma and patient serum samples. +circulation_biomarker_diagnosis_ns 31503420 hsa-mir-21 Dysautonomia, Familial Furthermore, we validated miR-21a-5p, miR-146a-5p, and miR-126a-3p as dysregulated in both murine doxycycline-induced FT and metastatic tumors, as well as in murine plasma and patient serum samples. +circulation_biomarker_diagnosis_ns 31503420 hsa-mir-146a Dysautonomia, Familial Furthermore, we validated miR-21a-5p, miR-146a-5p, and miR-126a-3p as dysregulated in both murine doxycycline-induced FT and metastatic tumors, as well as in murine plasma and patient serum samples. +circulation_biomarker_diagnosis_ns 31503420 hsa-mir-21 Neoplasm Metastasis Furthermore, we validated miR-21a-5p, miR-146a-5p, and miR-126a-3p as dysregulated in both murine doxycycline-induced FT and metastatic tumors, as well as in murine plasma and patient serum samples. +genetics_overexpression_promote 31503013 hsa-mir-148b Adenocarcinoma of Lung Furthermore, overexpression or inactivation of miR-148b-3p could enhance or reverse the inhibitory effect of long non-coding RNA H19 inhibition in lung adenocarcinoma cells, respectively. +other 31502865 hsa-let-7a Breast Neoplasms Ultimately, the coexpression analysis identified RRM2-let-7a-5p-SNHG16/MAL2 as key ceRNA subnetwork associated with prognosis of breast cancer. +lncRNA target 31502580 hsa-mir-425 Prostatic Neoplasms 5p upregulation might sensitize human PCa to DDP by targeting GSK3beta and inactivating the Wnt/beta-catenin signaling pathway. +genetics_knock down_suppress 31502570 hsa-mir-183 Colorectal Neoplasms The knockdown of miR +genetics_knock down_suppress 31502558 hsa-mir-212 Urinary Bladder Neoplasms 3p overexpression or NFIA knockdown. +transcription factor target 31502418 hsa-mir-155 Autism Spectrum Disorder Our data of increased gene expression of miR-155p5 in brains of children with ASD support the presence of localized inflammation in the amygdala and indicates that miR-155p5 may be targeted for therapy of ASD and other neurodegenerative diseases. +circulation_biomarker_diagnosis_ns 31501888 hsa-mir-122 Chemical and Drug Induced Liver Injury There were also small but statistically significant treatment-induced alterations in plasma total bile acids and microRNA-122, and these may indicate early hepatocellular stress required for immune-mediated hepatotoxicity in humans. +other 31501876 hsa-mir-29a Bicuspid Aortic Valve Disease Interestingly, we also found that only miR-29A is significantly downregulated in BAVs. +other 31501876 hsa-mir-29 Bicuspid Aortic Valve Disease Interestingly, we also found that only miR-29A is significantly downregulated in BAVs. +other 31501407 hsa-mir-486 Thyroid Cancer, Papillary 5p/KIAA1199/EMT axis might play a critical role in PTC invasion and metastasis and offers a potential therapeutic strategy for PTC. +transcription factor target 31501353 hsa-mir-1 Coronary Disease Our data indicate that miR-31 promotes Th22 differentiation through targeting Bach2 in CHD. +lncRNA target 31501273 hsa-mir-7 Alzheimer Disease Moreover, we found that the levels of miR-7 are also elevated in brains of AD patients; this inversely correlates with the expression of its target genes IRS-2 and IDE. +transcription factor target 31501273 hsa-mir-7 Metabolic Diseases Taken together, these results represent a novel branch of insulin action through the HNRNPK-miR-7 axis and highlight the possible implication of these posttranscriptional regulators in a range of diseases underlying metabolic dysregulation in the brain, from diabetes to Alzheimer's disease. +transcription factor target 31501273 hsa-mir-7 Diabetes Mellitus Taken together, these results represent a novel branch of insulin action through the HNRNPK-miR-7 axis and highlight the possible implication of these posttranscriptional regulators in a range of diseases underlying metabolic dysregulation in the brain, from diabetes to Alzheimer's disease. +lncRNA target 31500928 hsa-mir-1307 Ovarian Neoplasms CONCLUSIONS: Our data suggested that miR-1307 may be involved in the resistance of ovarian cancer to chemotherapy drugs via regulation of CIC, and should be further explored as a potential therapeutic target. +transcription factor target 31500865 hsa-mir-9 Ischemic Stroke In summary, our results suggest that the attenuation of miR-9 on ischemic injury may be involved in targeting ERMP1-mediated ER stress, which provides an available target for IS treatment. +lncRNA target 31500623 hsa-mir-21 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: In conclusion, lncRNA PLAC2 down-regulated miR-21 in NSCLC and inhibited cancer cell migration and invasion. +lncRNA target 31500509 hsa-mir-1 Cerebral Palsy Collectively, vitamin B1 and B12 up-regulates BDNF and its downstream PI3K/Akt signaling through MALAT1/miR-1 axis, thus suppressing neuron apoptosis and mitigating nerve injury in cerebral palsy rats. +genetics_knock down_promote 31500506 hsa-mir-200a Thyroid Carcinoma, Anaplastic Knockdown of MALAT1 or overexpression of miR-200a-3p inhibited cell proliferation, migration and invasion but increased apoptosis and autophagy formation in ATC cells. +genetics_overexpression_promote 31500453 hsa-mir-200a Stomach Neoplasms miR-200a-3p overexpression inhibits GC cell proliferation, cell cycle, and cell migration. +other 31500278 hsa-mir-92a Colonic Neoplasms We previously reported that colon cancer-derived EVs contain abundant miR-92a-3p and have a pro-angiogenic function. +other 31500139 hsa-mir-532 Diabetes Mellitus In literature, miR5p is known as a common down-regulated miRNA in diabetes and obesity, possibly providing a molecular link between cellular homeostasis, personal fitness levels, and health in aging. +other 31500139 hsa-mir-532 Obesity In literature, miR5p is known as a common down-regulated miRNA in diabetes and obesity, possibly providing a molecular link between cellular homeostasis, personal fitness levels, and health in aging. +genetics_overexpression_promote 31499680 hsa-mir-527 Carcinoma, Non-Small-Cell Lung Overexpression of miR-527 evidently suppressed NSCLC proliferation, invasion and EMT via TGF-beta/SMAD signaling pathway. +genetics_GWAS 31499476 hsa-mir-34c Coronary Artery Disease CONCLUSIONS: Our findings suggest that the pri-miR-34b/c rs4938723 polymorphism is associated with CAD susceptibility in the Chinese Han population. +genetics_GWAS 31499476 hsa-mir-34b Coronary Artery Disease CONCLUSIONS: Our findings suggest that the pri-miR-34b/c rs4938723 polymorphism is associated with CAD susceptibility in the Chinese Han population. +genetics_overexpression_suppress 31499447 hsa-mir-542 Ear Diseases As resulted from molecular profiling study there are 8 miRNA differentially expressed in OTA kidney vs control kidney, in which five miRNA were overexpressed in the kidney of OTA intoxicated animals: miR-497 (FC=6.34), miR-133a-3p (FC=5.75), miR +genetics_overexpression_suppress 31499447 hsa-mir-9840 Ear Diseases As resulted from molecular profiling study there are 8 miRNA differentially expressed in OTA kidney vs control kidney, in which five miRNA were overexpressed in the kidney of OTA intoxicated animals: miR-497 (FC=6.34), miR-133a-3p (FC=5.75), miR +genetics_overexpression_suppress 31499447 hsa-mir-490 Ear Diseases As resulted from molecular profiling study there are 8 miRNA differentially expressed in OTA kidney vs control kidney, in which five miRNA were overexpressed in the kidney of OTA intoxicated animals: miR-497 (FC=6.34), miR-133a-3p (FC=5.75), miR +genetics_overexpression_suppress 31499447 hsa-mir-497 Ear Diseases As resulted from molecular profiling study there are 8 miRNA differentially expressed in OTA kidney vs control kidney, in which five miRNA were overexpressed in the kidney of OTA intoxicated animals: miR-497 (FC=6.34), miR-133a-3p (FC=5.75), miR +genetics_overexpression_suppress 31499447 hsa-mir-34a Ear Diseases As resulted from molecular profiling study there are 8 miRNA differentially expressed in OTA kidney vs control kidney, in which five miRNA were overexpressed in the kidney of OTA intoxicated animals: miR-497 (FC=6.34), miR-133a-3p (FC=5.75), miR +genetics_overexpression_suppress 31499447 hsa-mir-133a Ear Diseases As resulted from molecular profiling study there are 8 miRNA differentially expressed in OTA kidney vs control kidney, in which five miRNA were overexpressed in the kidney of OTA intoxicated animals: miR-497 (FC=6.34), miR-133a-3p (FC=5.75), miR +genetics_overexpression_suppress 31499447 hsa-mir-423 Ear Diseases As resulted from molecular profiling study there are 8 miRNA differentially expressed in OTA kidney vs control kidney, in which five miRNA were overexpressed in the kidney of OTA intoxicated animals: miR-497 (FC=6.34), miR-133a-3p (FC=5.75), miR +genetics_overexpression_suppress 31499447 hsa-mir-421 Ear Diseases As resulted from molecular profiling study there are 8 miRNA differentially expressed in OTA kidney vs control kidney, in which five miRNA were overexpressed in the kidney of OTA intoxicated animals: miR-497 (FC=6.34), miR-133a-3p (FC=5.75), miR +lncRNA target 31499089 hsa-mir-124 Alzheimer Disease MicroRNA-124 (miR-124) is one of the most abundant miRNAs in the brain that is dysregulated in the hippocampus of AD animals. +other 31499089 hsa-mir-124 Cerebrovascular Disorders Downregulation of miR-124 expression resulted in Abeta deposition and a variety of cerebromicrovascular impairments, including the decline in microvascular density, reduced angiogenesis, accompanied by C1ql3 alteration. +lncRNA target 31499060 hsa-mir-221 Parkinson Disease In this study, we examined the existence of regulatory networks involving SNHG1, the miR-221/222 cluster and the cyclin-dependent kinase inhibitor 1B (CDKN1B/p27)/mammalian target of rapamycin (mTOR) signaling pathway in PD. +lncRNA target 31499059 hsa-mir-9 Vitiligo In conclusion, miR-9 was suppressed by IL-10 and inhibited migration of PIG1 cells to HaCaT cells during UVB-mediated vitiligo repigmentation. +other 31499051 hsa-mir-125a Constriction, Pathologic We show that regulation of the miR-125a-3p level has the potential to provide a new treatment for PAD and other proliferative vascular diseases. +lncRNA target 31498707 hsa-mir-483 Wilms Tumor 3p inhibited the doxorubicin-induced apoptosis in Wilms' tumor cells by the regulation of BAX and Bcl-2 expression. +other 31498525 hsa-mir-370 Uterine Cervical Neoplasms 3p, hsa-miR-199a-3p and hsa-miR-199b-3p) relative to HPV16Neg. +other 31498525 hsa-mir-1291 Uterine Cervical Neoplasms 3p, hsa-miR-199a-3p and hsa-miR-199b-3p) relative to HPV16Neg. +other 31498525 hsa-mir-151a Uterine Cervical Neoplasms 3p, hsa-miR-199a-3p and hsa-miR-199b-3p) relative to HPV16Neg. +other 31498525 hsa-mir-21 Uterine Cervical Neoplasms 3p, hsa-miR-199a-3p and hsa-miR-199b-3p) relative to HPV16Neg. +other 31498525 hsa-mir-199a Uterine Cervical Neoplasms 3p, hsa-miR-199a-3p and hsa-miR-199b-3p) relative to HPV16Neg. +transcription factor target 31498525 hsa-mir-5701 Uterine Cervical Neoplasms Furthermore, miR-5701 inhibits the proliferation of cervical cancer cells and suppresses the expression of THBS4 (P < 0.05), which was confirmed as a target gene of miR-5701. miR-5701 inhibits the proliferation of cervical cancer cells and the expression of its target gene THBS4. +other 31498525 hsa-mir-144 Uterine Cervical Neoplasms 3p, hsa-miR-199a-3p and hsa-miR-199b-3p) relative to HPV16Neg. +other 31498525 hsa-mir-101 Uterine Cervical Neoplasms 3p, hsa-miR-199a-3p and hsa-miR-199b-3p) relative to HPV16Neg. +lncRNA target 31498515 hsa-mir-149 Acute Lung Injury The MALAT1, myeloid differentiation factor 88 (MyD88), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6 levels were significantly increased, and the nuclear factor-kappaB (NF-kappaB) pathway was activated, but the miR-149 level was decreased in the LPS-induced ALI model. MALAT1 acts as a pro-inflammatory factor in ALI via the miR-149/MyD88/NF-kappaB axis and is therefore a potential novel therapeutic target for ALI treatment. +genetics_overexpression_promote 31498514 hsa-mir-938 Adenocarcinoma of Lung Overexpression of miR-938 promoted LUAD cell proliferation, whereas down-regulation of miR-938 had the opposite effect. +lncRNA target 31498486 hsa-mir-96 Carcinoma, Renal Cell In this study, miR-96 was found to be downregulated in RCC based on The Cancer Genome Atlas datasets analyses, and its target genes, which predicted by TargetScan, were investigated. +other 31498485 hsa-mir-4735 Intracranial Aneurysm The downregulated expression of miR-4735 in IA tissues leads to elevated expression of HIF-1, which activates autophagy and promotes autophagy-mediated SMC proliferation and migration. In conclusion, miR-4735 plays an important role in phenotypic modulation in IA by regulating autophagy-promoted SMC proliferation and migration. +lncRNA target 31498483 hsa-mir-215 Multiple Myeloma 5p mimics/inhibitors/negative control was transfected into MM cells. +other 31498480 hsa-mir-548c Gallbladder Neoplasms Moreover, ceRNAs such as XLOC_011309-miR-548c-3p-SPOCK1 and XLOC_012588-miRCEACAM6 can also be implicated in the pathogenesis of gallbladder cancer. +other 31498480 hsa-mir-765 Gallbladder Neoplasms Moreover, ceRNAs such as XLOC_011309-miR-548c-3p-SPOCK1 and XLOC_012588-miRCEACAM6 can also be implicated in the pathogenesis of gallbladder cancer. +genetics_overexpression_promote 31498117 hsa-mir-30 Carcinoma, Non-Small-Cell Lung Overexpression of miR +genetics_GWAS 31497998 hsa-mir-122 Nasopharyngeal Carcinoma Moreover, the oncogenic roles of DRAIC on NPC were reversed by the mutation of miR-122 binding sites on SATB1, simultaneous overexpression of miR-122, or depletion of SATB1. +lncRNA target 31497936 hsa-mir-101 Stomach Neoplasms Therefore, our results indicate that LINC01303 promotes the expression of EZH2 by inhibiting miR +other 31497917 hsa-mir-29c Stomach Neoplasms Subsequently, we verified that lncRNA MYOSLID regulates the proliferation and apoptosis of GC cells by acting as a ceRNA against miR-29c-3p. CONCLUSION: The lncRNA MYOSLID-miR-29c-3p-MCL-1 axis plays a key role in the development of GC. +other 31497299 hsa-mir-125b Colorectal Neoplasms In this analysis, ex-miR-125b exhibited the greatest upregulation in patients with progressive disease (PD) compared with the findings for patients with stable disease (SD) and healthy controls. In patients with SD, ex-miR-125b levels did not differ before and during treatment. +lncRNA target 31497237 hsa-mir-143 Colonic Neoplasms Collectively, our results revealed that ZEB2-AS1 was upregualted and functioned as an oncogene via regulating miR-143/bcl-2 axis in colon cancer. +other 31497231 hsa-mir-6516 Prostatic Neoplasms In conclusion, this finding suggests the SNHG20/miR5p/SCGB2A1 axis in PCa tumorigenesis, providing the novel insight for the molecular mechanism of PCa. +transcription factor target 31497219 hsa-mir-192 Fibrosis, Renal Moreover, in TGF-beta1 stimulated HK-2 cells, AS-IV clearly inhibited the expression levels of alpha-SMA, vimentin, collagen I, and miR-192 in a dose-dependent fashion while increased the expression level of E-cadherin in the same manner, indicating that AS-IV functioned the inhibitory role in renal tubulointerstitial fibrosis. +genetics_knock down_promote 31497218 hsa-mir-188 Prostatic Neoplasms Moreover, we determined the oncogene or anti-oncogene role of miR-188 in the PC through gain and loss function assay of miR-188 using transfection of miR-188 mimics and inhibitor. +genetics_overexpression_promote 31497212 hsa-mir-876 Glioma Overexpressed KIF20A reversed miR +lncRNA target 31497209 hsa-mir-186 Glioma In conclusion, our study reported for the first time that lncRNA-DLEU2 promotes glioma progression by targeting the miR +genetics_knock down_promote 31497207 hsa-mir-32 Stomach Neoplasms 5p on KLF2, the proliferation and migration assays were performed in both KLF2 overexpression and KLF2 knockdown gastric cancer cells. +genetics_knock down_suppress 31497204 hsa-mir-940 Glioma Functional experiments showed CKS1 as a target of miR-940, knockdown of CKS1 significantly induced the cell cycle arrest and restrained GBM cells proliferation, consistent with miR-940 treatment. +lncRNA target 31497197 hsa-mir-107 Adenocarcinoma of Lung Results indicated TINCR could constrain the expression of miR-107/miR-1286, and was a target of them in LUAD cells. These data revealed a possible regulatory mechanism in which upregulation of TINCR induced by Sp1 could constrain the migration and invasion through regulating miR-107 or miR-1286 in LUAD cells. +lncRNA target 31497197 hsa-mir-1286 Adenocarcinoma of Lung Results indicated TINCR could constrain the expression of miR-107/miR-1286, and was a target of them in LUAD cells. These data revealed a possible regulatory mechanism in which upregulation of TINCR induced by Sp1 could constrain the migration and invasion through regulating miR-107 or miR-1286 in LUAD cells. +transcription factor target 31497196 hsa-mir-16 Brain Injuries, Traumatic Together, these results demonstrate miR5p downregulation may accelerate fracture healing by enhancing the proliferation and inhibiting the apoptosis of osteoblasts in patients with both fractures and TBI. +genetics_overexpression_promote 31497188 hsa-mir-193a Lung Neoplasms In conclusion, this study indicated that S100A6 overexpression could promote the proliferation, invasion, migration and angiogenesis of lung cancer cells by inhibiting the P53 acetylation and miR193a overexpression could reversed the above effects by decreasing the S100A6 expression in both vitro and vivo experiments. +other 31496785 hsa-mir-146a Ischemic Stroke Conclusion In conclusion, the expression of miRNA 146a is significantly downregulated in ischemic stroke patients. +genetics_overexpression_promote 31496749 hsa-mir-26a Thyroid Cancer, Papillary Conclusion Overexpression of miR-26a-5p depresses proliferation, invasion, metastasis of PTC via Wnt5a. +circRNA target 31496747 hsa-mir-338 Breast Neoplasms 3p, which further targeted and regulated HOXA3. +lncRNA target 31496744 hsa-mir-145 Colonic Neoplasms Furthermore, we found that LINC00491 positively regulates SERPINE1 expression through sponging miR-145 and promoting the proliferation, migration, and invasion of colon adenocarcinoma cells, thus playing an oncogenic role during colon adenocarcinoma pathogenesis. +genetics_overexpression_promote 31496735 hsa-mir-1286 Melanoma HCP5 overexpression decreased SKCM cell malignancy in vitro by upregulating RARRES3, possibly via sponging miR-1286. +lncRNA target 31496733 hsa-mir-503 Ovarian Neoplasms 5p expression to further promote proliferation and depress apoptosis of OC cells through the JAK2-STAT3 pathway. +other 31496728 hsa-mir-499 esophagus adenocarcinoma Association of miRNA-499 rs3746444 A>G variants with adenocarcinoma of esophagogastric junction (AEG) risk and lymph node status. +genetics_overexpression_suppress 31496725 hsa-mir-15a Thyroid Cancer, Papillary Overexpression of miR-15a notably inhibited PTC cell proliferation and invasion via promoting apoptosis. +other 31496723 hsa-mir-217 Carcinoma, Non-Small-Cell Lung CONCLUSION: hsa_circ_0023404 promotes the proliferation, migration and invasion of NSCLC cells by regulating miR-217/ZEB1 axis, providing a fresh perspective on circRNAs in NSCLC development. +genetics_knock down_promote 31496625 hsa-mir-194 Liver Cirrhosis Loss of microRNA-194 (miR-194) has been reported in activated HSCs, but the actual role of miR-194 in liver fibrosis remains uncertain. +transcription factor target 31496296 hsa-mir-342 Leukemia, Myeloid, Acute In conclusion, our study confirmed that miR-342/Naa10p plays key roles in AML progression, providing insights into underlying mechanisms of AML pathogenesis and also a potential therapeutic target for this malignancy. +circulation_biomarker_diagnosis_ns 31495986 hsa-mir-210 Coronary Artery Disease CONCLUSIONS: Circulating let-7f, miR-19a, miR-126, miR-210, and miR-296 independently correlate with reduced RASP risk, while miR-19a, miR-126, miR-210, and miR-378 independently correlate with decreased restenosis risk in CAD patients underwent PCI with DES. +circulation_biomarker_diagnosis_ns 31495986 hsa-mir-19a Coronary Artery Disease CONCLUSIONS: Circulating let-7f, miR-19a, miR-126, miR-210, and miR-296 independently correlate with reduced RASP risk, while miR-19a, miR-126, miR-210, and miR-378 independently correlate with decreased restenosis risk in CAD patients underwent PCI with DES. +circulation_biomarker_diagnosis_ns 31495986 hsa-mir-126 Coronary Artery Disease CONCLUSIONS: Circulating let-7f, miR-19a, miR-126, miR-210, and miR-296 independently correlate with reduced RASP risk, while miR-19a, miR-126, miR-210, and miR-378 independently correlate with decreased restenosis risk in CAD patients underwent PCI with DES. +circulation_biomarker_diagnosis_ns 31495986 hsa-mir-378 Coronary Artery Disease CONCLUSIONS: Circulating let-7f, miR-19a, miR-126, miR-210, and miR-296 independently correlate with reduced RASP risk, while miR-19a, miR-126, miR-210, and miR-378 independently correlate with decreased restenosis risk in CAD patients underwent PCI with DES. +circulation_biomarker_diagnosis_ns 31495986 hsa-mir-296 Coronary Artery Disease CONCLUSIONS: Circulating let-7f, miR-19a, miR-126, miR-210, and miR-296 independently correlate with reduced RASP risk, while miR-19a, miR-126, miR-210, and miR-378 independently correlate with decreased restenosis risk in CAD patients underwent PCI with DES. +circulation_biomarker_diagnosis_ns 31495986 hsa-let-7f Coronary Artery Disease CONCLUSIONS: Circulating let-7f, miR-19a, miR-126, miR-210, and miR-296 independently correlate with reduced RASP risk, while miR-19a, miR-126, miR-210, and miR-378 independently correlate with decreased restenosis risk in CAD patients underwent PCI with DES. +other 31495827 hsa-mir-21 Arthritis, Rheumatoid Levels of miRNA21 were significantly lower in the XFC group compared to the AA model group (p<0.05). +genetics_GWAS 31495776 hsa-mir-24 Spinal Cord Injuries We indicate that UTX deletion can epigenetically promote the vascular regeneration and functional recovery post SCI by forming a regulatory network with miR-24. +lncRNA target 31495191 hsa-mir-142 Nasopharyngitis 3p may participate in the regulation of the body's inflammatory response through the LPS-TLR-TNF-alpha signaling pathway in chronic rhinosinusitis with nasal polyposis. +lncRNA target 31495191 hsa-mir-142 Nasal Polyps 3p may participate in the regulation of the body's inflammatory response through the LPS-TLR-TNF-alpha signaling pathway in chronic rhinosinusitis with nasal polyposis. +epigenetics 31494340 hsa-mir-140 Encephalomyelitis, Autoimmune, Experimental 5p regulated Th1 differentiation via DNA methylation and mitochondrial respiratory pathway. +lncRNA target 31494298 hsa-mir-142 Acute Lung Injury Results of our study demonstrated that miR-142a-3p exerts as a protective role in LPS-induced ALI through down-regulation of NF-kappaB signaling pathway. +lncRNA target 31494298 hsa-mir-142a Acute Lung Injury Results of our study demonstrated that miR-142a-3p exerts as a protective role in LPS-induced ALI through down-regulation of NF-kappaB signaling pathway. +other 31493405 hsa-mir-379 Glioblastoma Thus, we confirmed that circ-PITX1 exerted as a competing endogenous RNA (ceRNA) in glioblastoma by sponging miR5p to elevate MAP3K2 expression. +other 31493245 hsa-mir-202 Rhinitis, Allergic MiR5p/MATN2 are associated with regulatory T-cells differentiation and function in allergic rhinitis. +lncRNA target 31492847 hsa-mir-214 Lung Neoplasms Co-targeting miR +transcription factor target 31492753 hsa-mir-455 Breast Neoplasms We discovered a role for GATA3 in suppressing epithelial-to-mesenchymal transition (EMT) in breast cancer by activating miR +other 31492499 hsa-mir-335 Carcinoma, Renal Cell We studied the effect of hsa_circ_0035483 on gemcitabine sensitivity in RCC, and explored its regulatory effect on downstream hsa-miR-335 and Cyclin B1 (CCNB1). In addition, hsa_circ_0035483 promotes autophagy and tumor growth and enhances gemcitabine resistance in RCC by regulating hsa-miR-335/CCNB1, and silenced hsa_circ_0035483 can enhance gemcitabine sensitivity in vivo. +circulation_biomarker_diagnosis_up 31492495 hsa-mir-138 Arthritis, Rheumatoid RESULTS: miR-138 was upregulated in serum and synovial tissues of RA patients. +other 31492481 hsa-mir-626 Parkinson Disease Finally, we found that the mean expression level of hsa-miR-626 was significantly reduced in the CSF of patients with PD compared with AD and controls. +circulation_biomarker_diagnosis_ns 31492371 hsa-mir-21 Carcinoma, Hepatocellular The real time PCR results showed that miR-21 was differentially expressed in the serum of HCC patients and healthy volunteers. +other 31492208 hsa-mir-29b Ovarian Neoplasms This novel miR-29b-loaded Aptamer-directed liposome could potential serve as a new platform to improve the therapeutic outcome in ovarian cancers. +lncRNA target 31492194 hsa-mir-1523 Glioma CONCLUSION: LINC00174 accelerated carcinogenesis of glioma via sponging miR3p and increasing the SLC2A1 expression, which could be considered as a molecular target for glioma diagnosis and therapy. +other 31492150 hsa-mir-1246 Colorectal Neoplasms CONCLUSIONS: The present study demonstrates that the METTL3/miR-1246/SPRED2 axis plays an important role in tumor metastasis and provides a new m6A modification pattern in CRC development. +transcription factor target 31492116 hsa-mir-370 Breast Neoplasms CONCLUSIONS: Our results suggest that GRM4 might be a tumor suppressor gene in breast cancer under the direct regulation of miR +transcription factor target 31492116 hsa-mir-28 Breast Neoplasms CONCLUSIONS: Our results suggest that GRM4 might be a tumor suppressor gene in breast cancer under the direct regulation of miR +lncRNA target 31491450 hsa-mir-1 Glioblastoma Ectopic miR-1 expression in GBM cells inhibited proliferation and migration, increased sensitivity to apoptosis induced by the DNA alkylating agent temozolomide in vitro, and inhibited GBM tumorigenesis in vivo. +genetics_GWAS 31491426 hsa-mir-24 Retinal Degeneration In the retinal pigment epithelial (RPE) cells of Royal College of Surgeons (RCS) rats, an animal model of genetic retinal degeneration (RD), miR-24 was found lower and CHI3L1 level was higher in comparison with those in Sprague-Dawley (SD) rats. Thus, miR-24 and CHI3L1 might be the targets for developing more effective therapy for degenerative retinal diseases like AMD. +genetics_GWAS 31491426 hsa-mir-24 Retinal Detachment In the retinal pigment epithelial (RPE) cells of Royal College of Surgeons (RCS) rats, an animal model of genetic retinal degeneration (RD), miR-24 was found lower and CHI3L1 level was higher in comparison with those in Sprague-Dawley (SD) rats. The results revealed the protective roles for miR-24 to RPE cells and a mechanism for RD in RCS rats was proposed: extracellular stress stimuli first activate the NF-kappaB signaling pathway, which lowers miR-24 expression so that CHI3L1 increased. +genetics_GWAS 31491426 hsa-mir-24 Retinal Cone Dystrophy 3B In the retinal pigment epithelial (RPE) cells of Royal College of Surgeons (RCS) rats, an animal model of genetic retinal degeneration (RD), miR-24 was found lower and CHI3L1 level was higher in comparison with those in Sprague-Dawley (SD) rats. +transcription factor target 31491426 hsa-mir-24 Macular Degeneration Thus, miR-24 and CHI3L1 might be the targets for developing more effective therapy for degenerative retinal diseases like AMD. +genetics_GWAS 31490768 hsa-mir-3131 Breast Neoplasms CONCLUSION: It is concluded that, our findings did not support a relationship between pre-miR-3131 ins/del polymorphism and the risk of BC. +transcription factor target 31490757 hsa-mir-125a Inflammation The miR-125a-5p alleviated epileptic seizure and inflammation in PTZ-induced rats by suppressing its target gene, CAMK4. +transcription factor target 31490756 hsa-mir-34a Spinal Cord Injuries This study aims to explore the effect and possible mechanism of miR-34a on neuron apoptosis induced by Spinal Cord Injury (SCI). CONCLUSION: MiR-34a can downregulate CD47 expression to activate PI3K/AKT signal pathway, and thus inhibit SCI induced spinal neuron apoptosis. +transcription factor target 31490755 hsa-mir-125b Neurobehavioral Manifestations However, the role of miR-125b-5p in sevoflurane-induced cognitive impairments remains unclear. CONCLUSION: Altogether, these findings suggested that miR-125b-5p inhibitor could protect against the sevoflurane-induced cognitive impairments by targeting LIMK1. +genetics_overexpression_promote 31490362 hsa-mir-153 Prostatic Neoplasms Previously, miR-153 has been identified to be overexpressed in prostate cancer. +other 31490264 hsa-mir-15b Esophageal Squamous Cell Carcinoma 5p expression levels, ESCC patient clinical features association analysis results and the aforementioned TCGA bioinformatics analyses were similar. +other 31490264 hsa-mir-195 Esophageal Squamous Cell Carcinoma 5p expression levels, ESCC patient clinical features association analysis results and the aforementioned TCGA bioinformatics analyses were similar. +other 31490264 hsa-mir-135b Esophageal Squamous Cell Carcinoma 5p expression levels, ESCC patient clinical features association analysis results and the aforementioned TCGA bioinformatics analyses were similar. +lncRNA target 31490021 hsa-mir-194 Breast Neoplasms In conclusion, LINC00641 inhibits BC cell proliferation, migration, as well as invasion by sponging miR +lncRNA target 31490018 hsa-mir-876 Esophageal Neoplasms In our recent study, we have found that the expression of ciRS-7 is abnormally increased in the esophageal squamous cell carcinoma (ESCC), and may function as an oncogene to accelerate ESCC progression through sponging miR5p. +lncRNA target 31490018 hsa-mir-1299 Esophageal Neoplasms Taken together, this study has shed light on that circular RNA ciRS-7 inhibits autophagy of ESCC cells by functioning as miR-1299 sponge to target EGFR signaling. +lncRNA target 31489990 hsa-mir-125a Thyroid Cancer, Papillary Consistently, the colony formation ability and other metastasis-related traits of PTC cell are inhibited by miR-125a-3p transfection in vitro. +lncRNA target 31489964 hsa-mir-26b Spinal Cord Injuries Our study provides evidence that ADM may mediate miR-26b-inhibited OPC differentiation in SCI. +exosome 31489770 hsa-mir-20b Kidney Calculi To investigate whether ADSC-derived miR-20b-3p-enriched exosomes protect against kidney stones, an ethylene glycol (EG)-induced hyperoxaluria rat model and an in vitro model of oxalate-induced NRK-52E cells were established to explore the protective mechanism of miR-20b-3p. In conclusion, ADSC-derived miR-20b-3p-enriched exosomes protected against kidney stones by suppressing autophagy and inflammatory responses. +other 31489770 hsa-mir-20b Urinary Calculi Studies revealed that miR-20b-3p is down-regulated in hypercalciuric stone-forming rat kidney. +exosome 31489770 hsa-mir-20b Hyperoxaluria Furthermore, treatment with miR-20b-3p-enriched exosomes from ADSCs protected EG-induced hyperoxaluria rats, and cell experiments confirmed that co-culture with miR-20b-3p-enriched exosomes alleviated oxalate-induced cell autophagy and the inflammatory response by inhibiting ATG7 and TLR4. +circulation_biomarker_diagnosis_up 31489719 hsa-mir-145 Aortic Dissection RESULTS: The amounts of miR-145 in plasma and aortic specimens were markedly reduced in the AD group in comparison with control values (P < .05). +transcription factor target 31489649 hsa-mir-495 Pulmonary Fibrosis Collectively, miR3p might be a negative regulator of the EMT process in fibrosis formation by inhibiting the targeted S1PR3 gene. +genetics_overexpression_promote 31489582 hsa-mir-129 Neuralgia 5p alleviated neuropathic pain through downregulating high mobility group protein B1 (HMGB1) expression in CCI rats as overexpression of miR +genetics_overexpression_promote 31489579 hsa-mir-148a Glioblastoma Restoration of ITGA9 expression reversed the decreased viability, migration, and invasiveness of glioblastoma cells induced by miR-148a overexpression. +lncRNA target 31489578 hsa-mir-203a Stomach Neoplasms Upregulation of miR-203a attenuated the repressive effects of AWPPH on GC cell proliferation and invasion. AWPPH inhibited GC cell proliferation and invasion via miR-203a/DKK2 axis. +other 31489551 hsa-mir-194 Carcinoma, Pancreatic Ductal CONCLUSIONS: High expression of miR5p in peritoneal washings is associated with peritoneal recurrence and poor OS in patients with peritoneal cytology-negative PDAC. +genetics_overexpression_promote 31489147 hsa-mir-939 Complex Regional Pain Syndromes Our previous investigations identified a significant decrease of hsa-miR-939 in whole blood from CRPS patients compared to control; we also observed that overexpression of miR-939 can negatively regulate several proinflammatory genes in vitro. +circulation_biomarker_prognosis_ns 31489016 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck Therefore, present study was designed to investigate if miR-21 was expressed in plasma of patients with oral cancer, and further explore its diagnostic and prognostic potential. CONCLUSION: The expression of circulating miR-21 in plasma samples of oral cancer patients makes it a promising diagnostic and prognostic marker. +circulation_biomarker_diagnosis_ns 31488416 hsa-mir-223 Carcinoma, Non-Small-Cell Lung IMPACT Serum miR-223 determination may be proposed as a tool for refining NSCLC risk stratification, independent of smoking habit and age. +genetics_knock down_promote 31488193 hsa-mir-200c Breast Neoplasms Deficiency of miR-200b or miR-200c reversed the suppressive effect of circDENND4C knockdown on breast cancer progression. CONCLUSION: circDENND4C silence suppresses glycolysis, migration and invasion in breast cancer cells under hypoxia by increasing miR-200b and miR-200c. +genetics_knock down_promote 31488193 hsa-mir-200b Breast Neoplasms Deficiency of miR-200b or miR-200c reversed the suppressive effect of circDENND4C knockdown on breast cancer progression. CONCLUSION: circDENND4C silence suppresses glycolysis, migration and invasion in breast cancer cells under hypoxia by increasing miR-200b and miR-200c. +circulation_biomarker_diagnosis_ns 31487658 hsa-mir-21 Pre-Eclampsia We compared the expressions of 3 circulating miRs (miR-31, miR-21, and miR-16), which are related to the control of cell apoptosis, invasion, angiogenesis and immune tolerance in non-pregnancy (n=10), 20-34 gestational weeks normal pregnancy (20-34GW NP, n=20), early onset preeclampsia (EOPE, n=20), 34-41 gestational weeks normal pregnancy (34-41GW NP, n=20) and late onset preeclampsia (LOPE, n=20). This study is the first to demonstrate the difference, and circulating miR-31 may serve as a diagnostic biomarker for early onset preeclampsia meanwhile miR-21 might be a diagnostic biomarker for late onset preeclampsia. +circulation_biomarker_diagnosis_ns 31487658 hsa-mir-1 Pre-Eclampsia We compared the expressions of 3 circulating miRs (miR-31, miR-21, and miR-16), which are related to the control of cell apoptosis, invasion, angiogenesis and immune tolerance in non-pregnancy (n=10), 20-34 gestational weeks normal pregnancy (20-34GW NP, n=20), early onset preeclampsia (EOPE, n=20), 34-41 gestational weeks normal pregnancy (34-41GW NP, n=20) and late onset preeclampsia (LOPE, n=20). This study is the first to demonstrate the difference, and circulating miR-31 may serve as a diagnostic biomarker for early onset preeclampsia meanwhile miR-21 might be a diagnostic biomarker for late onset preeclampsia. +other 31487656 hsa-mir-155 Pre-Eclampsia 5p and miR155-5p are not related to PE-GDM group. +other 31487656 hsa-mir-21 Pre-Eclampsia 5p and miR155-5p are not related to PE-GDM group. +other 31487656 hsa-mir-155 Diabetes, Gestational 5p and miR155-5p are not related to PE-GDM group. +other 31487656 hsa-mir-21 Diabetes, Gestational 5p and miR155-5p are not related to PE-GDM group. +other 31487655 hsa-mir-210 Pre-Eclampsia CONCLUSIONS: MicroRNA-210 may be the noncoding RNA at the molecular level in which the increase in its level accompanies the progression of PE; and is closely associated with the severity of Preeclampsia. +other 31487625 hsa-mir-424 Pre-Eclampsia Expression of miR-424 in placenta was lower in patients with sPE, suggesting its role in the pathology of sPE. +other 31487369 hsa-mir-221 Triple Negative Breast Neoplasms We identified a four-biomarker signature based on miR-221, miR-1305, miR-4708, and RMDN2 expression levels that allowed for the subdivision of TNBC into high- or low-risk groups (Hazard Ratio - HR = 0.32; 95% Confidence Interval - CI = 0.11-0.91; p = 0.03) and are also statistically associated with survival outcome in subgroups of postmenopausal status (HR = 0.19; 95% CI = 0.04-0.90; p= 0.016), node negative status (HR = 0.12; 95% CI = 0.01-1.04; p = 0.026), and tumors larger than 2cm (HR = 0.21; 95% CI = 0.05-0.81; p = 0.021). +other 31487369 hsa-mir-1305 Triple Negative Breast Neoplasms We identified a four-biomarker signature based on miR-221, miR-1305, miR-4708, and RMDN2 expression levels that allowed for the subdivision of TNBC into high- or low-risk groups (Hazard Ratio - HR = 0.32; 95% Confidence Interval - CI = 0.11-0.91; p = 0.03) and are also statistically associated with survival outcome in subgroups of postmenopausal status (HR = 0.19; 95% CI = 0.04-0.90; p= 0.016), node negative status (HR = 0.12; 95% CI = 0.01-1.04; p = 0.026), and tumors larger than 2cm (HR = 0.21; 95% CI = 0.05-0.81; p = 0.021). +other 31487369 hsa-mir-4708 Triple Negative Breast Neoplasms We identified a four-biomarker signature based on miR-221, miR-1305, miR-4708, and RMDN2 expression levels that allowed for the subdivision of TNBC into high- or low-risk groups (Hazard Ratio - HR = 0.32; 95% Confidence Interval - CI = 0.11-0.91; p = 0.03) and are also statistically associated with survival outcome in subgroups of postmenopausal status (HR = 0.19; 95% CI = 0.04-0.90; p= 0.016), node negative status (HR = 0.12; 95% CI = 0.01-1.04; p = 0.026), and tumors larger than 2cm (HR = 0.21; 95% CI = 0.05-0.81; p = 0.021). +other 31487226 hsa-mir-126 von Willebrand Diseases Increases in factors nonspecific to endothelial damage, including von Willebrand factor and microRNA-126, occurred only after high-intensity interval exercise. +other 31487226 hsa-mir-126 Anodontia 5p (110%, P = 0.01). +other 31486923 hsa-mir-410 Pulpitis The objective of this study is to evaluate MMP-14 expression in odontoblasts and in the bulk of dental pulp of teeth with pulpitis; to determine the expression of microRNA-410 (miR-410) in pulp tissue, since sequence analysis suggests that miR-410 has potential binding site on MMP-14's 3'UTR, and hence, can regulate expression of the latter one. +other 31486923 hsa-mir-410 Inflammation Expression of miR-410 was found significantly lower in inflamed pulps than in healthy ones. This study demonstrates for the first time miR-410 expression in human dental pulp and that expression of this microRNA was downregulated in inflamed dental pulp and odontoblasts. +other 31486753 hsa-mir-138 Osteoarthritis 5p expression was down-regulated in OA and regulated SOX9 expression. +circulation_biomarker_diagnosis_up 31486513 hsa-mir-647 Angelman Syndrome RESULTS: Our data supported that miR-647 was upregulated and PTEN was downregulated in the serum of AS patients and ox-LDL-treated HA-VSMCs. +genetics_knock down_suppress 31486509 hsa-mir-26a Myocardial Reperfusion Injury In addition, knockdown of miR-26a significantly inhibited myocardial infarction caused by I/R injury, and reduced infarction area from (43.08+/-2.43) to (21.54+/-1.82) (p<0.05). +other 31486506 hsa-mir-124 Myocardial Ischemia MATERIALS AND METHODS: Myocardial ischemia rats' model was established to examine the expression level of miR-124. +transcription factor target 31486506 hsa-mir-124 Cardiomyopathies In this study, the role of miR-124 in the myocardial IR injury was examined. CONCLUSIONS: In the pathogenesis of MI, miR-124 promotes myocardial IR-induced cell death and apoptosis in cardiomyocyte by targeting SphK1. +other 31486506 hsa-mir-124 Myocardial Reperfusion Injury In this study, the role of miR-124 in the myocardial IR injury was examined. +transcription factor target 31486506 hsa-mir-124 Myocardial Infarction CONCLUSIONS: In the pathogenesis of MI, miR-124 promotes myocardial IR-induced cell death and apoptosis in cardiomyocyte by targeting SphK1. +lncRNA target 31486505 hsa-mir-155 Respiratory Distress Syndrome CONCLUSIONS: The miR-155/NF-kappaB signaling pathway influenced the changes of inflammatory factors in ARDS in neonatal pigs, which might be a potential target for eliminating the inflammatory response after ARDS in neonatal pigs. +other 31486504 hsa-mir-26a Brain Ischemia The relationship between miR-26a and PTEN was confirmed by Dual-Luciferase assay and human SH-SY5Y cells were treated with oxygen-glucose deprivation (OGD)/reperfusion to mimic I/R injury. +circulation_biomarker_diagnosis_up 31486501 hsa-mir-577 Leukemia, Myelogenous, Chronic, BCR-ABL Positive RESULTS: QRT-PCR results revealed that microRNA-577 level was notably decreased in peripheral blood of patients with CML, and microRNA-577 could inhibit the proliferation and cycle of CML cells. +genetics_overexpression_promote 31486500 hsa-mir-200a Melanoma Moreover, functional assays indicated that miR-200a overexpression markedly repressed melanoma cell proliferation, invasion, and migration capacities. +genetics_knock down_promote 31486498 hsa-mir-221 Breast Neoplasms 5p knockdown in migratory and invasive potentials of BCa cells. +genetics_knock down_promote 31486497 hsa-mir-205 Breast Neoplasms 5p, and the overexpression of FGF14-AS2 undermined the miR +lncRNA target 31486496 hsa-mir-361 Breast Neoplasms OBJECTIVE: This study was designed to investigate the expression level of circRNA_100876 in breast cancer (BC) tissues or cells, and to further explore whether it can promote cell metastasis and proliferative capacity via targeting microRNA- 361-3 p. +transcription factor target 31486492 hsa-mir-223 Squamous Cell Carcinoma of Head and Neck 3p acted as a tumor suppressor gene in OSCC by targeting SHOX2. +other 31486491 hsa-mir-497 Stomach Neoplasms 5p/PIK3R1 axis. +lncRNA target 31486490 hsa-mir-203 Pancreatic Carcinoma MiR-203 can regulate the proliferation and apoptosis of the pancreatic cancer cells by targeting the inhibited SOCS3 expression and regulating the JAK-STAT pathway activity. +lncRNA target 31486488 hsa-mir-30 Carcinoma, Hepatocellular 3p acted as a tumor gene in HCC by targeting BTG1 and it might be a potential therapeutic target for the HCC treatment. +lncRNA target 31486487 hsa-mir-184 Carcinoma, Renal Cell The downregulation of miR-184 in renal carcinoma cells could facilitate cell apoptosis and inhibited tumor proliferation or invasion possibly via modulating beta-catenin/TCF4 pathway. +lncRNA target 31486485 hsa-mir-10a Urinary Bladder Neoplasms In addition, ITGB1 might promote BCa cell proliferation via regulating microRNA-10a expression. +genetics_overexpression_promote 31486484 hsa-mir-135a Prostatic Neoplasms miR-135a overexpression inhibited cell proliferation and promoted cell apoptosis and paclitaxel sensitivity in prostate cancer cells. +lncRNA target 31486483 hsa-mir-574 Ovarian Neoplasms 3p functioned as a tumor suppressor in OC, which might be served as a potential target for the diagnosis and therapy for OC. +circulation_biomarker_diagnosis_ns 31486477 hsa-mir-579 Osteoporosis 3P in serum of patients with osteoporosis was significantly higher than that of normal controls. +lncRNA target 31486474 hsa-let-7 Spinal Cord Injuries CONCLUSIONS: Let-7 participates in the regulation of inflammatory response in SCI through the PI3K/Akt signaling pathway. +transcription factor target 31485783 hsa-mir-548b Lung Neoplasms In vivo, miR-548b-3p also suppressed tumor growth in xenografts model of lung cancer cells. Our results indicated that miR-548b-3p might be an anti-tumor target of lung cancer in the future. +genetics_overexpression_promote 31485677 hsa-mir-139 Breast Neoplasms Furthermore, overexpression of RAB1A counteracted the suppressing effects of miR1393p on breast cancer cell migration, invasion and epithelialtomesenchymal transition (EMT). +genetics_GWAS 31485673 hsa-mir-519d Epidural Abscess To investigate the role of microRNA (miR)519d3p in postoperative epidural scar formation and its regulation of the bone morphogenetic protein and activin membranebound inhibitor (BAMBI), miR519d3p and BAMBI expression levels in the lumbar disc of patients who had undergone laminectomy were detected with reverse transcriptionquantitative polymerase chain reaction and western blotting. +lncRNA target 31485672 hsa-mir-107 Breast Neoplasms NEAT1 promoted the progression of BC cells through inhibiting apoptosisassociated genes and promoting cell cycle and invasionassociated gene expression, whereas miR107 served the opposite function. +other 31485667 hsa-mir-132 Metabolic Diseases Notably, 6 miRNAs (miR175p, miR29c3p, miR34a5p, miR103a3p, miR107 and miR1323p) were found in the four resources (HMDD, miR2Disease, MDHGI, and DisGeNET) used for these analyses, presenting a stronger association with the diseases. +other 31485667 hsa-mir-107 Metabolic Diseases Notably, 6 miRNAs (miR175p, miR29c3p, miR34a5p, miR103a3p, miR107 and miR1323p) were found in the four resources (HMDD, miR2Disease, MDHGI, and DisGeNET) used for these analyses, presenting a stronger association with the diseases. +other 31485667 hsa-mir-29c Metabolic Diseases Notably, 6 miRNAs (miR175p, miR29c3p, miR34a5p, miR103a3p, miR107 and miR1323p) were found in the four resources (HMDD, miR2Disease, MDHGI, and DisGeNET) used for these analyses, presenting a stronger association with the diseases. +other 31485667 hsa-mir-34a Metabolic Diseases Notably, 6 miRNAs (miR175p, miR29c3p, miR34a5p, miR103a3p, miR107 and miR1323p) were found in the four resources (HMDD, miR2Disease, MDHGI, and DisGeNET) used for these analyses, presenting a stronger association with the diseases. +other 31485667 hsa-mir-17 Metabolic Diseases Notably, 6 miRNAs (miR175p, miR29c3p, miR34a5p, miR103a3p, miR107 and miR1323p) were found in the four resources (HMDD, miR2Disease, MDHGI, and DisGeNET) used for these analyses, presenting a stronger association with the diseases. +other 31485667 hsa-mir-103a Metabolic Diseases Notably, 6 miRNAs (miR175p, miR29c3p, miR34a5p, miR103a3p, miR107 and miR1323p) were found in the four resources (HMDD, miR2Disease, MDHGI, and DisGeNET) used for these analyses, presenting a stronger association with the diseases. +genetics_overexpression_promote 31485658 hsa-mir-212 Esophageal Squamous Cell Carcinoma In the present study, an in vitro cell model of lentivirusmediated gainoffunction demonstrated promotion of ESCC cell migration and invasion when miR212 was overexpressed, and no effect on cell proliferation. +genetics_knock down_promote 31485653 hsa-mir-101 Carcinoma, Non-Small-Cell Lung In conclusion, lncRNA PTAR was proposed to promote NSCLC cell growth through sponging and inactivating miR101, which may be a possible mechanism underlying miR101 copy loss in human NSCLC. +genetics_overexpression_promote 31485646 hsa-mir-373 Liver Neoplasms Overexpressing miR373 mimics in liver cancer cell lines decreased cell proliferation and invasion, suggesting that miR373 exerts antitumor effects in liver cancer. +lncRNA target 31485645 hsa-mir-1 Prostatic Neoplasms In conclusion, MALAT1 serving as a degradable miRNA sponge, may sequester miR13p from CORO1C and by silencing MALAT1, migration, invasion and epithelialmesenchymal transition may be inhibited in prostate cancer cells. +genetics_knock down_promote 31485634 hsa-mir-206 Carcinoma, Renal Cell Furthermore, the overexpression of miR206 notably suppressed the proliferation, migration and invasion of RCC cells, and these effects were enhanced by the knockdown of vascular endothelial growth factor (VEGF); cell growth and metastasis induced by miR206 inhibitors could be reversed by the knockdown of VEGF. +lncRNA target 31485621 hsa-mir-488 Osteoporosis The present results suggested that miR488 is a negative regulator of psoraleninduced BMSC osteogenic differentiation by targeting Runx2, providing a possible therapeutic target for osteoporosis. +lncRNA target 31485620 hsa-mir-192 Breast Neoplasms Therefore, the present study demonstrated that miR192 serves an important role as a regulator in breast cancer and the miR192/CAV1 axis has a potential as a therapeutic target for treatment of breast cancer. +genetics_overexpression_promote 31485617 hsa-mir-497 Carcinoma, Non-Small-Cell Lung In the NSCLC cell line A549, miR497 overexpression inhibited cell proliferation and migration. In conclusion, the results of the present study identified miR497 as a potential tumor suppressor gene in NSCLC that may function via repressing FGFR1 expression, and AKT and JNK signaling. +other 31485607 hsa-mir-217 Uterine Cervical Neoplasms MicroRNA (miR)217 serves a pivotal role in the progression of colorectal cancer, renal cell carcinoma and glioma, however, the role of miR217 in cervical cancer (CC) remains unclear. In the present study, the mechanism of miR217 in cervical cancer was explored. +lncRNA target 31485607 hsa-mir-217 Hamartoma Syndrome, Multiple MAPK1 was upregulated in patients with CC and was a target gene of miR217. +other 31485607 hsa-mir-217 high grade glioma MicroRNA (miR)217 serves a pivotal role in the progression of colorectal cancer, renal cell carcinoma and glioma, however, the role of miR217 in cervical cancer (CC) remains unclear. +other 31485607 hsa-mir-217 Colorectal Neoplasms MicroRNA (miR)217 serves a pivotal role in the progression of colorectal cancer, renal cell carcinoma and glioma, however, the role of miR217 in cervical cancer (CC) remains unclear. +other 31485607 hsa-mir-217 nonpapillary renal cell carcinoma MicroRNA (miR)217 serves a pivotal role in the progression of colorectal cancer, renal cell carcinoma and glioma, however, the role of miR217 in cervical cancer (CC) remains unclear. +genetics_overexpression_promote 31485604 hsa-mir-200a Sepsis In conclusion, to the best of our knowledge, the results of the present study demonstrated for the first time that overexpression of miRNA200a3p promoted inflammation in sepsisinduced brain injury through reactive oxygen speciesinduced NLRP3. +genetics_overexpression_promote 31485604 hsa-mir-200a Myocardial Injury In conclusion, to the best of our knowledge, the results of the present study demonstrated for the first time that overexpression of miRNA200a3p promoted inflammation in sepsisinduced brain injury through reactive oxygen speciesinduced NLRP3. +lncRNA target 31485601 hsa-mir-379 Diabetic Nephropathies This study aimed to explore whether miR3795p is associated with renal fibrosis in DN and to elucidate the underlying mechanisms. Taken together, the findings of this study suggest that miR3795p is highly involved in renal fibrosis in DN, and that it may be a potential effective therapeutic target for DN. +lncRNA target 31485601 hsa-mir-379 Fibrosis, Renal This study aimed to explore whether miR3795p is associated with renal fibrosis in DN and to elucidate the underlying mechanisms. Taken together, the findings of this study suggest that miR3795p is highly involved in renal fibrosis in DN, and that it may be a potential effective therapeutic target for DN. +genetics_overexpression_suppress 31485599 hsa-mir-9 Thyroid Carcinoma, Anaplastic miR95p overexpression sensitized ATC cells to DDP. +lncRNA target 31485598 hsa-mir-122 Liver Neoplasms In addition, it has been observed that HBV inhibited microRNA (miR)122 expression in hepatocytes; however, the molecular mechanisms involved in liver cancer development remain unknown and further investigations are required. +lncRNA target 31485593 hsa-mir-5191 Colorectal Neoplasms These findings suggested a novel tumorsuppressive function for miR5191 in CRC, and its potential applicability for the development of anticancer miRNA therapeutics. +lncRNA target 31485019 hsa-mir-1246 Glioblastoma Moreover, miR-1246 was enriched in the CSF of GBM patients and decreased after tumor resection. Moreover, our results suggested that miR-1246 in the CSF of GBM patients may be a novel biomarker for GBM diagnosis and that treatment targeting microRNA-1246 may contribute to antitumor immunotherapy. +other 31484947 hsa-mir-1261 Multiple Sclerosis Among the constructed GRNs (referred as TF_gene_miRNA), POU3F2_CDK6_hsa-miR3p, MEIS1_CASC3_hsa-miR-1261, STAT3_OGG1_hsa-miR-298, and TCF4_FMR1_hsa-miR-301b were top-ranked and differentially regulated in all classes of MS compared to control. +other 31484947 hsa-mir-298 Multiple Sclerosis Among the constructed GRNs (referred as TF_gene_miRNA), POU3F2_CDK6_hsa-miR3p, MEIS1_CASC3_hsa-miR-1261, STAT3_OGG1_hsa-miR-298, and TCF4_FMR1_hsa-miR-301b were top-ranked and differentially regulated in all classes of MS compared to control. +other 31484947 hsa-mir-590 Multiple Sclerosis Among the constructed GRNs (referred as TF_gene_miRNA), POU3F2_CDK6_hsa-miR3p, MEIS1_CASC3_hsa-miR-1261, STAT3_OGG1_hsa-miR-298, and TCF4_FMR1_hsa-miR-301b were top-ranked and differentially regulated in all classes of MS compared to control. +circulation_biomarker_diagnosis_ns 31484870 hsa-mir-3667 ST Elevation Myocardial Infarction Our results show that high levels of circulating miR +circulation_biomarker_diagnosis_ns 31484730 hsa-mir-155 Arthritis, Rheumatoid We studied membrane TNF (mTNF) expression on blood monocytes, polarization into macrophages, miR-155 expression, and the effect of anti-TNF on these biomarkers in RA patients. +circulation_biomarker_diagnosis_ns 31484346 hsa-mir-150 Prostatic Neoplasms 5p plasma variations in PCa patients are associated with concordant changes in prostate cancer tissues; however, given the heterogeneous nature of previous findings of miR +lncRNA target 31484042 hsa-mir-146a Non-alcoholic Fatty Liver Disease RESULTS: High levels of NEAT1 and ROCK1, and low level of miR-146a-5p were identified in NAFLD models. CONCLUSION: NEAT1 may regulate NAFLD through miR-146a-5p targeting ROCK1, and further affect AMPK/SREBP pathway. +genetics_overexpression_promote 31483954 hsa-mir-22 Arthritis, Rheumatoid These results indicated that miR-22 overexpression could restrain the activity of inflammation cells in RA by targeting IL6R and might be concerned with the inhibition of NF-kappaB pathway. +genetics_knock down_promote 31483914 hsa-mir-577 Uterine Cervical Neoplasms RAB14 overexpression or miR-577 knockdown restored the suppressing effect of TMPO-AS1 knockdown on the biological behavior of CC cells. CONCLUSIONS: The present study has revealed a novel TMPO-AS1/miR-577/RAB14 regulatory axis in the pathogenesis of CC, highlighting TMPO-AS1 as a promising therapeutic target for CC patients. +circulation_biomarker_diagnosis_up 31483888 hsa-mir-24 Squamous Cell Carcinoma of Head and Neck CONCLUSION: These results suggested miR-21, miR-24, and miR-29a in serum of patients with oral squamous cell carcinoma comparing with normal group can be used as potent markers for carcinoma detection and also may be a potentially therapeutic approach in the future. +circulation_biomarker_diagnosis_up 31483888 hsa-mir-29a Squamous Cell Carcinoma of Head and Neck CONCLUSION: These results suggested miR-21, miR-24, and miR-29a in serum of patients with oral squamous cell carcinoma comparing with normal group can be used as potent markers for carcinoma detection and also may be a potentially therapeutic approach in the future. +circulation_biomarker_diagnosis_up 31483888 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck CONCLUSION: These results suggested miR-21, miR-24, and miR-29a in serum of patients with oral squamous cell carcinoma comparing with normal group can be used as potent markers for carcinoma detection and also may be a potentially therapeutic approach in the future. +genetics_overexpression_suppress 31483572 hsa-mir-497 Lymphoma, Large B-Cell, Diffuse SNHG16 overexpression rescued miR +circulation_biomarker_diagnosis_up 31483179 hsa-mir-1 Polymyositis Although there were no significant differences in the clinical data and the initial prednisolone (PSL) dose between the two groups, PSL dose at 16 weeks, cumulative PSL dose until 16 weeks, and frequency of serious infections were significantly higher in the high miR-1 group as compared to the normal group (p = .025, .036, and .026, respectively).Conclusion: We propose serum miR-1 as a promising novel biomarker for predicting therapeutic response in PM/DM-ILD. +circulation_biomarker_diagnosis_up 31483179 hsa-mir-1 Dermatomyositis Although there were no significant differences in the clinical data and the initial prednisolone (PSL) dose between the two groups, PSL dose at 16 weeks, cumulative PSL dose until 16 weeks, and frequency of serious infections were significantly higher in the high miR-1 group as compared to the normal group (p = .025, .036, and .026, respectively).Conclusion: We propose serum miR-1 as a promising novel biomarker for predicting therapeutic response in PM/DM-ILD. +circulation_biomarker_diagnosis_up 31483179 hsa-mir-1 Lung Diseases, Interstitial Although there were no significant differences in the clinical data and the initial prednisolone (PSL) dose between the two groups, PSL dose at 16 weeks, cumulative PSL dose until 16 weeks, and frequency of serious infections were significantly higher in the high miR-1 group as compared to the normal group (p = .025, .036, and .026, respectively).Conclusion: We propose serum miR-1 as a promising novel biomarker for predicting therapeutic response in PM/DM-ILD. +other 31483161 hsa-mir-34b Stomach Diseases pylori) eradication, expression of miR-124a, miR-34b, and miR-34c was examined in nonneoplastic gastric specimens after successful H. +other 31483161 hsa-mir-124a Atrophy The atrophic type, an informative endoscopic feature for histological intestinal metaplasia, showed lower expression of miR-124a. +other 31483161 hsa-mir-124a Stomach Diseases pylori) eradication, expression of miR-124a, miR-34b, and miR-34c was examined in nonneoplastic gastric specimens after successful H. +other 31483161 hsa-mir-34c Stomach Diseases pylori) eradication, expression of miR-124a, miR-34b, and miR-34c was examined in nonneoplastic gastric specimens after successful H. +other 31483161 hsa-mir-124a Intestinal Diseases The atrophic type, an informative endoscopic feature for histological intestinal metaplasia, showed lower expression of miR-124a. +lncRNA target 31483122 hsa-mir-193b Non-alcoholic Fatty Liver Disease CONCLUSION: A variant on CD82 gene and a miR-193b expression dysregulation may have a role in the development and progression of NAFLD and its sequelae. +circulation_biomarker_diagnosis_ns 31483058 hsa-mir-221 Prostatic Neoplasms Our results of analysis of miR-21, miR-141, miR-18a and miR-221 in the plasma of PC patients showed that miR-18a is a powerful discriminator of PC patients from healthy controls as it had the highest AUC (0.966; 95% CI, 0.937-1.000), while miR-221 provided better differentiation of metastatic from localised PC (sensitivity was 92.9% at 100% specificity), and when we combine miR-18a and miR-221 for differentiating patients with MPC, it will increase the sensitivity to 96.4% at a specificity of 100% (AUC, 0.997; 95% CI, 0.988-1.0) (p < .000). +circulation_biomarker_diagnosis_ns 31483058 hsa-mir-141 Prostatic Neoplasms Our results of analysis of miR-21, miR-141, miR-18a and miR-221 in the plasma of PC patients showed that miR-18a is a powerful discriminator of PC patients from healthy controls as it had the highest AUC (0.966; 95% CI, 0.937-1.000), while miR-221 provided better differentiation of metastatic from localised PC (sensitivity was 92.9% at 100% specificity), and when we combine miR-18a and miR-221 for differentiating patients with MPC, it will increase the sensitivity to 96.4% at a specificity of 100% (AUC, 0.997; 95% CI, 0.988-1.0) (p < .000). +circulation_biomarker_diagnosis_ns 31483058 hsa-mir-18a Prostatic Neoplasms Our results of analysis of miR-21, miR-141, miR-18a and miR-221 in the plasma of PC patients showed that miR-18a is a powerful discriminator of PC patients from healthy controls as it had the highest AUC (0.966; 95% CI, 0.937-1.000), while miR-221 provided better differentiation of metastatic from localised PC (sensitivity was 92.9% at 100% specificity), and when we combine miR-18a and miR-221 for differentiating patients with MPC, it will increase the sensitivity to 96.4% at a specificity of 100% (AUC, 0.997; 95% CI, 0.988-1.0) (p < .000). +circulation_biomarker_diagnosis_ns 31483058 hsa-mir-21 Prostatic Neoplasms Our results of analysis of miR-21, miR-141, miR-18a and miR-221 in the plasma of PC patients showed that miR-18a is a powerful discriminator of PC patients from healthy controls as it had the highest AUC (0.966; 95% CI, 0.937-1.000), while miR-221 provided better differentiation of metastatic from localised PC (sensitivity was 92.9% at 100% specificity), and when we combine miR-18a and miR-221 for differentiating patients with MPC, it will increase the sensitivity to 96.4% at a specificity of 100% (AUC, 0.997; 95% CI, 0.988-1.0) (p < .000). +circulation_biomarker_prognosis_ns 31482406 hsa-mir-21 Colorectal Neoplasms The current study aimed to evaluate serum miR-21 expression levels as potential biomarkers for diagnosis and prognosis of colorectal cancer (CRC) patients. CONCLUSION: The results of this study indicated that miR-21 expression levels in serum can be considered as a novel non-invasive biomarker for early detection and prognosis of CRC patients. +genetics_knock down_suppress 31482398 hsa-mir-204 Retinoblastoma Taken together, the knockdown of BANCR inhibited cell proliferation, apoptosis, invasion, and migration in RB via targeting miR +lncRNA target 31482267 hsa-mir-29a Glioblastoma Mir-29a expression inhibited orthotopic GBM xenograft growth. +lncRNA target 31482255 hsa-mir-29b Fibrosis, Renal CONCLUSION: Our study has revealed that rAAV6 is the most suitable serotype for kidney-targeted gene delivery and rAAV6-mediated miR-29b delivery into kidney TECs can suppress established renal fibrosis. +genetics_overexpression_promote 31482067 hsa-mir-21 Glioblastoma One of the overexpressed miRNAs in GBM is miR-21 which promotes proliferation, invasion and metastatic behaviors of tumor cells. +other 31481984 hsa-mir-210 Mesothelioma, Malignant In PE cells, combining miR-143, miR-210, and miR-200c could differentiate MPM with an area under the curve (AUC) of 0.92. These results suggest that the expression of miR-143, miR-210, and miR-200c in PE cells might provide a signature for diagnosing MPM. +other 31481984 hsa-mir-143 Mesothelioma, Malignant In PE cells, combining miR-143, miR-210, and miR-200c could differentiate MPM with an area under the curve (AUC) of 0.92. These results suggest that the expression of miR-143, miR-210, and miR-200c in PE cells might provide a signature for diagnosing MPM. +other 31481984 hsa-mir-200c Mesothelioma, Malignant In PE cells, combining miR-143, miR-210, and miR-200c could differentiate MPM with an area under the curve (AUC) of 0.92. These results suggest that the expression of miR-143, miR-210, and miR-200c in PE cells might provide a signature for diagnosing MPM. +lncRNA target 31481748 hsa-mir-138 Triple Negative Breast Neoplasms Our report of miR-138 as an oncogenic driver in TNBC, positions it as a viable target for oligonucleotide therapeutics and we envision the potential value of using antimiR-138 as an adjuvant therapy to alleviate this therapeutically intractable cancer. +genetics_knock down_suppress 31481734 hsa-mir-222 Breast Neoplasms MiR-222 overexpression, or LBR knockdown, was sufficient to induce NFs to show the CAF characteristics of enhanced migration, invasion and senescence, and furthermore, the conditioned medium from these fibroblasts induced increased BC cell migration and invasion. CONCLUSION: MiR-222/LBR have key roles in controlling pro-progression influences of CAFs in BC. +circulation_biomarker_diagnosis_up 31481696 hsa-mir-155 White Coat Hypertension The aim of the present study was to explore the association of miR-155 with blood pressure and inflammatory markers, and to investigate the predictive value of circulating miR-155 for white coat hypertension (WCH). +other 31481527 hsa-mir-98 Prostatic Neoplasms 5p/HMGA2 pathway is involved in the development and progression of PCa. +lncRNA target 31481517 hsa-mir-29a Myocardial Reperfusion Injury Inhibition of miR-29a improved myocardial I/R injury by targeting SIRT1 through suppressing oxidative stress and NLRP3-mediated pyroptosis. +exosome 31481080 hsa-mir-159 Triple Negative Breast Neoplasms Binding occurred through a modified version of a disintegrin and metalloproteinase 15 (A15) expressed on exosomal membranes (A15-Exo), which facilitated co-delivery of therapeutic quantities of doxorubicin (Dox) and cholesterol-modified miRNA 159 (Cho-miR159) to triple-negative breast cancer (TNBC) cells, both in vitro and in vivo. Therefore, our data demonstrate the synergistic efficacy of co-delivering miR159 and Dox by targeted Exo for TNBC therapy. +other 31480991 hsa-mir-181a Stomach Neoplasms MALAT1 competes with AKT3 for miR-181a-5p binding, thereby upregulating the AKT3 protein level and ultimately promoting the growth of gastric adenocarcinoma. +other 31480990 hsa-mir-9 Carcinoma, Hepatocellular Our data indicate the critical involvement of LINC00467/miR5p/PPARA signalling in the incidence and progression of HCC. +genetics_overexpression_suppress 31480879 hsa-mir-10b Myocardial Infarction Overexpression of miR-10b-5p in the murine model of MI significantly reduced MI size, improved cardiac function, and inhibited apoptosis. +lncRNA target 31480771 hsa-mir-204 Depressive Disorder, Major Together, results from these preclinical studies conclude that decreased AR may accelerate the stress-induced MDD via altering miR5p/BDNF/AKT/MAPK signaling, and targeting this newly identified signaling may help in the development of better therapeutic approaches to reduce the development of MDD. +other 31480766 hsa-mir-217 Prostatic Neoplasms Furthermore, four biomarkers (ANPEP, mir-217, mir-592, mir-6715b) were found to distinguish between the two PCa stages and were highly correlated (average r = /- 0.75) with corresponding aggressiveness-related imaging features in both tumor stages. +other 31480766 hsa-mir-6715b Prostatic Neoplasms Furthermore, four biomarkers (ANPEP, mir-217, mir-592, mir-6715b) were found to distinguish between the two PCa stages and were highly correlated (average r = /- 0.75) with corresponding aggressiveness-related imaging features in both tumor stages. +other 31480766 hsa-mir-592 Prostatic Neoplasms Furthermore, four biomarkers (ANPEP, mir-217, mir-592, mir-6715b) were found to distinguish between the two PCa stages and were highly correlated (average r = /- 0.75) with corresponding aggressiveness-related imaging features in both tumor stages. +lncRNA target 31480202 hsa-mir-26a Progeria Qualitative real-time polymerase chain reaction and Western blotting were used to verify the DHCR24 mRNA and protein expression in pGCs, respectively, after transfecting with miR-26a mimic and miR-26a inhibitor. +lncRNA target 31479923 hsa-mir-382 Diabetes Mellitus, Type 2 Collectively, the key observations of the study provide evidence that inhibition of MALAT1 elevates miR3p to repress resistin, which consequently underlies the mechanism of exercise protecting against IR, highlighting a direction for T2DM therapy development. +other 31479922 hsa-mir-1270 Ovarian Neoplasms In summary, our study demonstrated that Cdr1as sensitizes ovarian cancer to cisplatin by regulating the miR-1270/SCAI signaling pathway. +other 31479774 hsa-mir-146b Hypercholesterolemia Forced expression of miR-146b using a miR mimic could constitute a novel therapeutic strategy to improve ischemia-induced neovascularization in atherosclerotic conditions. +lncRNA target 31479757 hsa-mir-731 Craniocerebral Trauma In summary, CPF exposure could induce apoptosis while inhibited autophagy in head kidney of common carp via the regulation of miR +lncRNA target 31479757 hsa-mir-2188 Craniocerebral Trauma In summary, CPF exposure could induce apoptosis while inhibited autophagy in head kidney of common carp via the regulation of miR +other 31479730 hsa-mir-200a Depression Thus we conclude that miR-200a-3p might be a specific biomarker of central sensitization in chronic pain and depression. +other 31479730 hsa-mir-200a Chronic Pain Thus we conclude that miR-200a-3p might be a specific biomarker of central sensitization in chronic pain and depression. +tissue_expression_ns 31479716 hsa-mir-34a Colitis In the present study we evaluated the aberrant expression of a selected panel of miRNAs (miR-181b, miR-31, miR-34a, miR-146b, miR-221, and miR-155) that regulate the crosstalk between NF-kappaB and STAT3 during colitis-associated tumorigenesis. +tissue_expression_ns 31479716 hsa-mir-1 Colitis In the present study we evaluated the aberrant expression of a selected panel of miRNAs (miR-181b, miR-31, miR-34a, miR-146b, miR-221, and miR-155) that regulate the crosstalk between NF-kappaB and STAT3 during colitis-associated tumorigenesis. +tissue_expression_ns 31479716 hsa-mir-181b Colitis In the present study we evaluated the aberrant expression of a selected panel of miRNAs (miR-181b, miR-31, miR-34a, miR-146b, miR-221, and miR-155) that regulate the crosstalk between NF-kappaB and STAT3 during colitis-associated tumorigenesis. +circRNA target 31479715 hsa-mir-377 Carcinoma, Non-Small-Cell Lung Mechanically, circ-PRMT5 could simultaneously effectively sponge three miRNAs (miR-377, miR-382 and miR-498) and alleviate their repression on the well-known oncogenic EZH2, resulting in increased EZH2 expression, thereby facilitating NSCLC progression. Overall, our data indicate that circ-PRMT5 is an oncogenic circRNA in NSCLC that can promote the growth of NSCLC via regulation of miR-377/382/498-EZH2 axis. +circRNA target 31479715 hsa-mir-382 Carcinoma, Non-Small-Cell Lung Mechanically, circ-PRMT5 could simultaneously effectively sponge three miRNAs (miR-377, miR-382 and miR-498) and alleviate their repression on the well-known oncogenic EZH2, resulting in increased EZH2 expression, thereby facilitating NSCLC progression. Overall, our data indicate that circ-PRMT5 is an oncogenic circRNA in NSCLC that can promote the growth of NSCLC via regulation of miR-377/382/498-EZH2 axis. +circulation_biomarker_diagnosis_ns 31479685 hsa-mir-145 Carcinoma, Hepatocellular In this study, the MCT4-mediated lactate efflux in HCC was blocked using microRNA-145(miR-145), which would force the endogenously generated lactate to accumulate within tumor cells in a self-regulated manner, resulting in the acidification of the cytoplasmic compartment as well as partial neutralization for pH in the tumor extracellular environment. +other 31479413 hsa-mir-203a Melanoma 5p showed altered expression in all three melanoma types vs. +other 31479413 hsa-mir-19a Melanoma 5p showed altered expression in all three melanoma types vs. +other 31479413 hsa-mir-9 Melanoma 5p showed altered expression in all three melanoma types vs. +other 31479413 hsa-mir-27b Melanoma 5p showed altered expression in all three melanoma types vs. +genetics_knock down_promote 31478836 hsa-mir-204 Warburg micro syndrome 1 The loss of lymphatics caused by miR-204 deficiency can be largely rescued by either endothelial autonomous expression of miR-204 or by suppression of NFATC1. +transcription factor target 31478836 hsa-mir-204 Lymphatic Diseases We also identify the NFATC1 transcription factor as a key miR-204 target in human and zebrafish, and show that NFATC1 suppression leads to lymphatic hyperplasia. +other 31478245 hsa-mir-219-1 Stomach Neoplasms 1. +lncRNA target 31478244 hsa-mir-218 Osteoporosis, Postmenopausal 5p mimics, and inhibitor significantly promoted, inhibited the osteoblast differentiation of PMOP BMMSCs, respectively. +other 31478117 hsa-mir-26a Glioblastoma CONCLUSIONS MiRNA-26a expression turned out to be a promising predictor of therapy response and clinical outcome in glioblastoma patients treated with carmustine wafer implantation. +transcription factor target 31477833 hsa-mir-148a Glioblastoma Our findings provide a new mechanism for miR-148a-mediated GBM cell invasion and reveal previously unreported targets of miR-148a as well as novel miR-148a-mediated regulatory networks in GBM. +other 31477638 hsa-mir-129 high grade glioma 3p. +other 31477638 hsa-mir-495 high grade glioma 3p. +lncRNA target 31477582 hsa-mir-128 Osteoporosis Furthermore, silencing SIRT6 significantly inhibited the promoting effect of the miR-128 inhibitor on the expression of osteoblast markers.Conclusion: The above results confirmed that miR-128 inhibited osteoblast differentiation in OP by down-regulating SIRT6 expression, thus accelerating the development of OP. +lncRNA target 31477445 hsa-mir-122 Carcinoma, Hepatocellular Over-expression of miR-122 induced apoptosis and inhibited cell viability of HCC by down-regulating TLR4, enhanced the expression of pro-apoptotic genes and suppressed the expression of anti-apoptotic genes. +genetics_knock down_suppress 31477326 hsa-mir-1193 Carcinoma, Squamous Cell, Cutaneous Gain- and loss-of-function assays showed that miR-1193 acted as an inhibitor of proliferation and migration in CSCC cells. +other 31477209 hsa-mir-424 Fetal Growth Retardation CONCLUSION: MiR-424 may be associated with the pathogenesis of FGR by modulating trophoblast-derived cell line proliferation and invasion. +transcription factor target 31476692 hsa-mir-124 Shock, Septic Additionally, miR-124 may serve as a useful biomarker to alleviate the severity of septic shock-induced lung injury. +transcription factor target 31476692 hsa-mir-124 Lung Injury Additionally, miR-124 may serve as a useful biomarker to alleviate the severity of septic shock-induced lung injury. +other 31476383 hsa-mir-10a Intestinal Atresia More importantly, we identified a novel circRNA, termed circINHA, that was downregulated during atresia in ovarian follicles, and we confirmed a direct interaction between miR-10a-5p and circINHA. +transcription factor target 31476383 hsa-mir-10a Atrophy Then, we used a dual luciferase activity assay to demonstrate CTGF as a direct functional target of miR-10a-5p, which was upregulated in atresic follicles and promoted the apoptosis of GCs in vitro. +lncRNA target 31476285 hsa-mir-411 Carcinoma, Renal Cell dependent CDH2 inhibition, highlighting a potential target for RCC treatment. +lncRNA target 31475459 hsa-mir-214 Lung Neoplasms In summary, our results showed that SM-inhibited NSCLC cell growth through the reciprocal interaction between HOTAIR and miR3p, which ultimately suppressed PDPK1 gene expression. +circulation_biomarker_diagnosis_ns 31475171 hsa-mir-103b Brucellosis, Bovine CONCLUSIONS: The serum miR-103b level markedly increases after Brucella infection and has the potential to serve as an auxiliary diagnostic indicator for Brucella infection that deserves further investigation. +circulation_biomarker_diagnosis_up 31474826 hsa-mir-126 Cerebral Hemorrhage 3p attenuates intracerebral hemorrhage-induced blood-brain barrier disruption, which is associated with down-regulated expression of VCAM-1 in hemorrhagic area. +other 31473901 hsa-mir-146a Pneumonia Protective Effect of Trans-chalcone Against High-Fat Diet-Induced Pulmonary Inflammation Is Associated with Changes in miR-146a And pro-Inflammatory Cytokines Expression in Male Rats. +other 31473888 hsa-mir-122 Lymphoma This study was performed to evaluate the hepatocyte-derived microRNA (miR)-122 as novel diagnostic biomarker in canine lymphoma. +lncRNA target 31473844 hsa-mir-29b Arthritis, Rheumatoid The available data collectively suggest that TNF-alpha-elicited miR-29b potentiates resistance to apoptosis in PBMs from RA patients via inhibition of HBP1 signaling, and testing patients for miR-29b/HBP1 expression ratios may provide more accurate prognostic information and could influence the recommended course of immunotherapy. +genetics_overexpression_promote 31473750 hsa-mir-421 Carcinoma, Non-Small-Cell Lung Furthermore, a gain of function assay showed that overexpression of miR-421 could promote NSCLC cell proliferation and cell cycle progression. +genetics_overexpression_promote 31473323 hsa-mir-18a Osteosarcoma Furthermore, the suppressor of cytokine signaling 5 (SOCS5) was confirmed a target gene of miR-18a-5p by luciferase gene reporter assay and SOCS5 suppression by miR-18a-5p attenuated the effects of FER1L4 overexpression on the OS cells apoptosis and the expressed levels of PI3K, AKT, Twist1, N-cadherin and Vimentin. In conclusion, our data indicated thatthe overexpression of FER1L4 promoted apoptosis and inhibited the EMT markers expression and PI3K/AKT signaling pathway activation in OS cells via downregulating miR-18a-5p to promote SOCS5. +lncRNA target 31473306 hsa-mir-148a Scapuloperoneal Myopathy, X-Linked Dominant Interestingly, suppression of miR-148a in a conditionally immortalized chief cell line induced up-regulation of CD44 variant 9 (CD44v9), one of the transcripts expressed at an early stage of SPEM development, and DNA methyltransferase 1 (Dnmt1), an established target of miR-148a. These findings suggest that the alteration of miR-148a expression is an early event in the process of chief cell transdifferentiation into SPEM. +genetics_knock down_promote 31473252 hsa-mir-17 Triple Negative Breast Neoplasms JAB1 knockdown in TNBC cells mimicked the effect of miR-17 overexpression and led to significant decreases in cell proliferation, colony formation, and migration, increased p27 expression, and enhanced cisplatin sensitivity. +lncRNA target 31473194 hsa-mir-455 Brain Injuries, Traumatic SIGNIFICANCE: The application of CNA effectively treats TBI-induced memory deficits by increasing miR3p and by inhibiting HDAC2. +genetics_overexpression_suppress 31472300 hsa-mir-365 Cartilage Diseases Overexpression of HDAC4 abolished miR-365 rescued end plate chondrocyte degeneration during ICMT application. +lncRNA target 31472261 hsa-mir-500 Dysentery 5p targeting to NFATC4, miR-500 targeting to ELK1, HSPA2 and IL7R, and miR-92b-3p targeting to CLCF1 were probably involved in piglet resisting C. +lncRNA target 31472261 hsa-mir-7134 Dysentery 5p targeting to NFATC4, miR-500 targeting to ELK1, HSPA2 and IL7R, and miR-92b-3p targeting to CLCF1 were probably involved in piglet resisting C. +lncRNA target 31472261 hsa-mir-92b Dysentery 5p targeting to NFATC4, miR-500 targeting to ELK1, HSPA2 and IL7R, and miR-92b-3p targeting to CLCF1 were probably involved in piglet resisting C. +lncRNA target 31472228 hsa-mir-92a Stomach Neoplasms These results highlighted the antagonistic roles of ECM1 and miR-92a in GC development, which may serve as a new target for gastric cancer. +other 31472145 hsa-mir-146a Osteoarthritis Results from quantitative real-time PCR (Q-PCR) showed that, in OA patients and OA cell model, the expression of MALAT1 and PI3K was clearly reduced, while the miR-146a levels were increased. +genetics_GWAS 31472066 hsa-mir-196a-2 Diabetes Mellitus, Type 1 We aimed, for the first time, to investigate the expression of miR-196a2 in T1DM and the association of miR-196a2 (rs11614913) polymorphism with susceptibility of T1DM in a sample of patients from Cairo, Egypt. +genetics_overexpression_promote 31472047 hsa-mir-532 Colorectal Neoplasms Overexpression of NKD1 significantly down-regulated miR-532 overexpression and promoted CRC cell invasion and metastasis (p < 0.05). +lncRNA target 31471872 hsa-mir-32 Colorectal Neoplasms SNHG14 regulates CRC progression via miR5p/SKIL axis, providing a novel point in treatment of CRC patients. +genetics_overexpression_promote 31471584 hsa-mir-140 Breast Neoplasms Overexpression of miR-140 sensitizes breast cancer cells to chemotherapeutic agents and overcomes drug resistance in breast cancer. +virus_miRNA 31471531 ebv-mir-BART8 Nasopharyngeal Carcinoma BART8-3p promotes radioresistance in nasopharyngeal carcinoma by regulating ATM/ATR signaling pathway +lncRNA target 31470827 hsa-mir-221 Carcinoma BACKGROUND: MiR-221, acting as onco-miR or oncosuppressor-miR, plays an important role in tumor progression; however, the prognostic value of miR-221 in human carcinomas is controversial and inconclusive. CONCLUSION: MiR-221 was shown to be associated with a poor OS in human carcinomas, and thus may serve as a useful predictor of clinical outcomes. +circulation_biomarker_diagnosis_ns 31470644 hsa-let-7f Liver Cirrhosis Analysis of the plasma of patients with significant liver fibrosis (F >/= 2) and no or mild fibrosis (F = 0-1), using miRNA +circulation_biomarker_diagnosis_ns 31470644 hsa-mir-29a Liver Cirrhosis Analysis of the plasma of patients with significant liver fibrosis (F >/= 2) and no or mild fibrosis (F = 0-1), using miRNA +circulation_biomarker_diagnosis_ns 31470644 hsa-mir-451a Liver Cirrhosis Analysis of the plasma of patients with significant liver fibrosis (F >/= 2) and no or mild fibrosis (F = 0-1), using miRNA +circulation_biomarker_diagnosis_ns 31470644 hsa-mir-122 Liver Cirrhosis Analysis of the plasma of patients with significant liver fibrosis (F >/= 2) and no or mild fibrosis (F = 0-1), using miRNA +circulation_biomarker_diagnosis_ns 31470644 hsa-mir-142 Liver Cirrhosis Analysis of the plasma of patients with significant liver fibrosis (F >/= 2) and no or mild fibrosis (F = 0-1), using miRNA +circulation_biomarker_diagnosis_ns 31470644 hsa-mir-378a Liver Cirrhosis Analysis of the plasma of patients with significant liver fibrosis (F >/= 2) and no or mild fibrosis (F = 0-1), using miRNA +other 31470144 hsa-mir-146a familial temporal lobe epilepsy 3 Therefore, we assessed the expression of miR-146a, 34a, 1260, 1275, 1298, 451, 132 and 142-3p in the neocortex of 12 patients with mTLE and compared them with miRs expression found in 10 control samples. +other 31470144 hsa-mir-34a familial temporal lobe epilepsy 3 Differential expression of miR-34a, 451, 1260, 1275 and 1298 in the neocortex of patients with mesial temporal lobe epilepsy. +other 31469874 hsa-mir-21 Colorectal Neoplasms However, four of differentially expressed miRNAs, including miR-21, miR-17, miR-20a and miR-32 represent the miRNAs characteristic for different tumor types, including breast, colon, lung, pancreas, prostate and stomach cancer. +other 31469874 hsa-mir-20a Colorectal Neoplasms However, four of differentially expressed miRNAs, including miR-21, miR-17, miR-20a and miR-32 represent the miRNAs characteristic for different tumor types, including breast, colon, lung, pancreas, prostate and stomach cancer. +other 31469874 hsa-mir-2 Colorectal Neoplasms However, four of differentially expressed miRNAs, including miR-21, miR-17, miR-20a and miR-32 represent the miRNAs characteristic for different tumor types, including breast, colon, lung, pancreas, prostate and stomach cancer. +other 31469874 hsa-mir-17 Colorectal Neoplasms However, four of differentially expressed miRNAs, including miR-21, miR-17, miR-20a and miR-32 represent the miRNAs characteristic for different tumor types, including breast, colon, lung, pancreas, prostate and stomach cancer. +other 31469602 hsa-mir-221 Obesity, Abdominal miR3p is one of the highly enriched miRNAs in obese PVAT and PVAT-derived EVs. +exosome 31469602 hsa-mir-221 Inflammation Our findings provide an EV-miR3p-mediated mechanism by which PVAT triggers an early-stage vascular remodeling in the context of obesity-associated inflammation.-Li, X., Ballantyne, L. +exosome 31469602 hsa-mir-221 Obesity Our findings provide an EV-miR3p-mediated mechanism by which PVAT triggers an early-stage vascular remodeling in the context of obesity-associated inflammation.-Li, X., Ballantyne, L. +transcription factor target 31469602 hsa-mir-221 Vascular Diseases Local delivery of miR3p mimic in femoral artery causes vascular dysfunction by suppressing the contractile genes in the arterial wall. +other 31469434 hsa-mir-29a Nasopharyngeal Carcinoma Hsa-miR-29a-3p and hsa-miR-103a-3p were not, possibly due to lower number of advanced stage NPC cases included in this subset. +other 31469434 hsa-mir-103a Nasopharyngeal Carcinoma Hsa-miR-29a-3p and hsa-miR-103a-3p were not, possibly due to lower number of advanced stage NPC cases included in this subset. +other 31469292 hsa-mir-619 Hemangioma, Cavernous The LINC00342-miR5p-HDGF signaling pathway could regulate cell proliferation and apoptosis in HemECs.NEW & NOTEWORTHY The role of LINC00342 in infantile hemangiomas has not yet been elucidated. +lncRNA target 31469189 hsa-mir-137 Colorectal Neoplasms SNHG1 increased RICTOR level in CRC via sponging miR-137. +transcription factor target 31469179 hsa-mir-155 Stomach Neoplasms Functional studies showed that the role of miR5p might lead to good prognosis in EBV-positive GC through promoting cell apoptosis and cell cycle arrest, as well as inhibiting tumor proliferation. +other 31469043 hsa-mir-421 Hypoxia Sirt3-Jun N-terminal kinase/activator protein 1 axis is a novel molecular mechanism that accommodates hypoxia/reoxygenation-induced oxidative stress and apoptosis and provides a new direction for the study and treatment of hypoxia/reoxygenation. +other 31469043 hsa-mir-421 Myocardial Infarction miRNA-421 (miR-421) plays a significant role in the initiation of apoptosis and myocardial infarction. +other 31469043 hsa-mir-421 Myocardial Reperfusion Injury However, the molecular regulation of miR-421 in myocardial ischemia-reperfusion injury requires further elucidation. +other 31468997 hsa-mir-463 Tibial Neuropathy 3p were detected at days 0, 3, 7, 12, 18 and 24 post-injury. +genetics_knock down_suppress 31468997 hsa-mir-463 Nervous System Diseases The data on gain- and loss-of-function demonstrated that miR +other 31468622 hsa-mir-33a Diabetes Mellitus, Type 2 The aim of the study is to clarify the effect of ghrelin treatment on the messenger RNA (mRNA) expression of the cannabinoid receptor 1 (Cnr1/CB1) and glucagon-like peptide 1 receptor (Glp1r/GLP-1R) as well as microRNAs (miR)-122 and miR-33a in the liver of rats with type 2 diabetes mellitus (T2DM). Furthermore, the increase in miR-33a expression level was reduced in the treatment group compared to rats with T2DM. +other 31468594 hsa-mir-708 Stomach Neoplasms 5p/USF1 pathway contributed to the development of gastric cancer. +exosome 31468561 hsa-mir-221 Peritonsillar Abscess Analyses of the biological potency of exosomes derived from HQ-transformed malignant cells in which miR-221 levels were decreased using an inhibitor, showed that both miR-221 levels and proliferation of recipient cells were decreased, but still were higher than those of normal 16HBE cells. +other 31468534 hsa-mir-675 Glioma In this study, we aimed to explore the potential role of H19/miR-675/vitamin D receptor (VDR) in the effect of CUR against glioma. In summary, it is the first time that the involvement of a negative feedback loop of H19/miR-675/VDR has been demonstrated in the development of glioma. +transcription factor target 31467907 hsa-mir-210 Osteoarthritis In conclusion, upregulation of miR-210 in synovial fluid may occur in the early stage of OA and can be a useful biomarker for early diagnosis of OA. +exosome 31467883 hsa-mir-27a Respiratory Distress Syndrome Further, a subset of exosomal miRNAs, including the miR-146a, miR-27a, miR-126, and miR-155 in ARDS group exhibited significantly elevated levels than those in non-ARDS group. The combined expression of miR-126, miR-27a, miR-146a, and miR-155 predicted ARDS with an area under the curve of 0.909 (95 % CI 0.815 -1). +exosome 31467883 hsa-mir-146a Respiratory Distress Syndrome Further, a subset of exosomal miRNAs, including the miR-146a, miR-27a, miR-126, and miR-155 in ARDS group exhibited significantly elevated levels than those in non-ARDS group. The combined expression of miR-126, miR-27a, miR-146a, and miR-155 predicted ARDS with an area under the curve of 0.909 (95 % CI 0.815 -1). +exosome 31467883 hsa-mir-155 Community-Acquired Pneumonia Further, a subset of exosomal miRNAs, including the miR-146a, miR-27a, miR-126, and miR-155 in ARDS group exhibited significantly elevated levels than those in non-ARDS group. The combined expression of miR-126, miR-27a, miR-146a, and miR-155 predicted ARDS with an area under the curve of 0.909 (95 % CI 0.815 -1). +exosome 31467883 hsa-mir-27a Community-Acquired Pneumonia Further, a subset of exosomal miRNAs, including the miR-146a, miR-27a, miR-126, and miR-155 in ARDS group exhibited significantly elevated levels than those in non-ARDS group. The combined expression of miR-126, miR-27a, miR-146a, and miR-155 predicted ARDS with an area under the curve of 0.909 (95 % CI 0.815 -1). +exosome 31467883 hsa-mir-146a Community-Acquired Pneumonia Further, a subset of exosomal miRNAs, including the miR-146a, miR-27a, miR-126, and miR-155 in ARDS group exhibited significantly elevated levels than those in non-ARDS group. The combined expression of miR-126, miR-27a, miR-146a, and miR-155 predicted ARDS with an area under the curve of 0.909 (95 % CI 0.815 -1). +exosome 31467883 hsa-mir-126 Community-Acquired Pneumonia Further, a subset of exosomal miRNAs, including the miR-146a, miR-27a, miR-126, and miR-155 in ARDS group exhibited significantly elevated levels than those in non-ARDS group. The combined expression of miR-126, miR-27a, miR-146a, and miR-155 predicted ARDS with an area under the curve of 0.909 (95 % CI 0.815 -1). +exosome 31467883 hsa-mir-126 Respiratory Distress Syndrome Further, a subset of exosomal miRNAs, including the miR-146a, miR-27a, miR-126, and miR-155 in ARDS group exhibited significantly elevated levels than those in non-ARDS group. The combined expression of miR-126, miR-27a, miR-146a, and miR-155 predicted ARDS with an area under the curve of 0.909 (95 % CI 0.815 -1). +exosome 31467883 hsa-mir-155 Respiratory Distress Syndrome Further, a subset of exosomal miRNAs, including the miR-146a, miR-27a, miR-126, and miR-155 in ARDS group exhibited significantly elevated levels than those in non-ARDS group. The combined expression of miR-126, miR-27a, miR-146a, and miR-155 predicted ARDS with an area under the curve of 0.909 (95 % CI 0.815 -1). +other 31467618 hsa-mir-200a Ovarian Neoplasms We identified four MIR200 members (MIR200A, MIR200B, MIR200C, and MIR429) and MIR25 as being differentially expressed among malignant or benign ovarian tumor patients and healthy controls. +other 31467618 hsa-mir-429 Ovarian Neoplasms We identified four MIR200 members (MIR200A, MIR200B, MIR200C, and MIR429) and MIR25 as being differentially expressed among malignant or benign ovarian tumor patients and healthy controls. +other 31467618 hsa-mir-200c Ovarian Neoplasms We identified four MIR200 members (MIR200A, MIR200B, MIR200C, and MIR429) and MIR25 as being differentially expressed among malignant or benign ovarian tumor patients and healthy controls. +other 31467618 hsa-mir-200b Ovarian Neoplasms We identified four MIR200 members (MIR200A, MIR200B, MIR200C, and MIR429) and MIR25 as being differentially expressed among malignant or benign ovarian tumor patients and healthy controls. +other 31467618 hsa-mir-25 Ovarian Neoplasms We identified four MIR200 members (MIR200A, MIR200B, MIR200C, and MIR429) and MIR25 as being differentially expressed among malignant or benign ovarian tumor patients and healthy controls. +circulation_biomarker_diagnosis_ns 31467618 hsa-mir-200 Ovarian Neoplasms In the meta-analysis, these five miRNAs yielded a pooled area under the receiver operating characteristic (ROC) curve (AUC) of 0.78 (sensitivity: 64%, specificity: 88%) in discriminating OC from healthy controls, while the four MIR200 members demonstrated a summary AUC of 0.81 (sensitivity: 92%, specificity: 69%) in differing OC cases from patients with benign disease. The circulating MIR200 family has the potential to become reliable and noninvasive biomarkers for OC diagnosis. +other 31467373 hsa-mir-9 Acquired Immunodeficiency Syndrome Furthermore, we identify miR5p as an important intermediate in TGF-beta-mediated BLIMP-1 upregulation and consequent HIV latency. +epigenetics 31467363 hsa-mir-129-2 Stomach Neoplasms 2 methylation in non-IM was an independent predictive marker of GC in H. +epigenetics 31467363 hsa-mir-34c Stomach Neoplasms pylori eradication (Cohort 1) and aspirin use (Cohort 2) on the methylation of microRNAs (miRNAs), such as miR-34c, miR-124a-3, miR2, and miR-137, in the gastric mucosa with and without GC, i.e., in atrophic mucosal glands without intestinal metaplasia (non-IM) and intestinal metaplastic glands (IM). +epigenetics 31467363 hsa-mir-124a Stomach Neoplasms pylori eradication (Cohort 1) and aspirin use (Cohort 2) on the methylation of microRNAs (miRNAs), such as miR-34c, miR-124a-3, miR2, and miR-137, in the gastric mucosa with and without GC, i.e., in atrophic mucosal glands without intestinal metaplasia (non-IM) and intestinal metaplastic glands (IM). +epigenetics 31467363 hsa-mir-137 Stomach Neoplasms pylori eradication (Cohort 1) and aspirin use (Cohort 2) on the methylation of microRNAs (miRNAs), such as miR-34c, miR-124a-3, miR2, and miR-137, in the gastric mucosa with and without GC, i.e., in atrophic mucosal glands without intestinal metaplasia (non-IM) and intestinal metaplastic glands (IM). +circulation_biomarker_diagnosis_ns 31467274 hsa-mir-17 Gastrointestinal Neoplasms Furthermore, miR5p methylation level in serum samples distinguished early pancreatic cancer patients from healthy controls with extremely high sensitivity and specificity. +genetics_overexpression_promote 31467172 hsa-mir-34b Colonic Neoplasms Furthermore, overexpression of miR-34b inhibited proliferation, migration and invasion, while promoted apoptosis in colon cancer cells. +other 31467122 hsa-mir-146b Leukemia, Large Granular Lymphocytic Restoring miR-146b expression in CD8 T-LGLs lead to a reduction of HuR protein and, in turn, of FasL mRNA expression, thus providing mechanistic insights for the existence of a STAT3-miR146b-FasL axis and neutropenia in T-LGLL. +other 31466915 hsa-mir-125a Combined Saposin Deficiency FINDINGS: MiR-125a is significantly decreased in PsA synovium and inversely associated with macroscopic vascularity. +lncRNA target 31466915 hsa-mir-125a Ataxia Neuropathy Spectrum In-vitro, miR-125a inhibition promoted EC tube formation, branching, migration and invasion, effects paralleled by a shift in their metabolic profile towards glycolysis. +lncRNA target 31466138 hsa-mir-124 Carcinoma, Hepatocellular 3p inhibited HCC metastasis by targeting Slug. +genetics_overexpression_promote 31465786 hsa-mir-214 Uterine Cervical Neoplasms In this study, we either CRISPR knocked out or overexpressed miR-214 in cervical cancer cells and analyzed the global mRNA expression by Next Generation Sequencing (NGS) It was observed that a total of 108 genes were upregulated and 178 downregulated between the samples, above and below the baseline respectively. +other 31465725 hsa-mir-370 Arthritis, Rheumatoid 5p, were considered to be connected with the common pathogenesis of PsA, PV, RA, and GA. +other 31465725 hsa-mir-199a Arthritis, Rheumatoid 5p, were considered to be connected with the common pathogenesis of PsA, PV, RA, and GA. +other 31465725 hsa-mir-589 Arthritis, Gouty 5p, were considered to be connected with the common pathogenesis of PsA, PV, RA, and GA. +other 31465725 hsa-mir-589 Arthritis, Psoriatic 5p, were considered to be connected with the common pathogenesis of PsA, PV, RA, and GA. +other 31465725 hsa-mir-769 Arthritis, Rheumatoid 5p, were considered to be connected with the common pathogenesis of PsA, PV, RA, and GA. +other 31465725 hsa-mir-769 Arthritis, Psoriatic 5p, were considered to be connected with the common pathogenesis of PsA, PV, RA, and GA. +other 31465725 hsa-mir-199a Arthritis, Psoriatic 5p, were considered to be connected with the common pathogenesis of PsA, PV, RA, and GA. +other 31465725 hsa-mir-151a Arthritis, Gouty 5p, were considered to be connected with the common pathogenesis of PsA, PV, RA, and GA. +other 31465725 hsa-mir-769 Arthritis, Gouty 5p, were considered to be connected with the common pathogenesis of PsA, PV, RA, and GA. +other 31465725 hsa-mir-151a Arthritis, Rheumatoid 5p, were considered to be connected with the common pathogenesis of PsA, PV, RA, and GA. +other 31465725 hsa-mir-151a Arthritis, Psoriatic 5p, were considered to be connected with the common pathogenesis of PsA, PV, RA, and GA. +other 31465725 hsa-mir-370 Arthritis, Gouty 5p, were considered to be connected with the common pathogenesis of PsA, PV, RA, and GA. +other 31465725 hsa-mir-370 psoriasis 1 5p, were considered to be connected with the common pathogenesis of PsA, PV, RA, and GA. +other 31465725 hsa-mir-370 Arthritis, Psoriatic 5p, were considered to be connected with the common pathogenesis of PsA, PV, RA, and GA. +other 31465725 hsa-mir-589 Arthritis, Rheumatoid 5p, were considered to be connected with the common pathogenesis of PsA, PV, RA, and GA. +other 31465725 hsa-mir-589 psoriasis 1 5p, were considered to be connected with the common pathogenesis of PsA, PV, RA, and GA. +other 31465725 hsa-mir-199a psoriasis 1 5p, were considered to be connected with the common pathogenesis of PsA, PV, RA, and GA. +other 31465725 hsa-mir-151a psoriasis 1 5p, were considered to be connected with the common pathogenesis of PsA, PV, RA, and GA. +other 31465725 hsa-mir-199a Arthritis, Gouty 5p, were considered to be connected with the common pathogenesis of PsA, PV, RA, and GA. +other 31465725 hsa-mir-769 psoriasis 1 5p, were considered to be connected with the common pathogenesis of PsA, PV, RA, and GA. +genetics_overexpression_promote 31465630 hsa-mir-20b Cardiomegaly Moreover, CHAR overexpression mitigated the repression of PTEN and activation of AKT by miR-20b, and as such, it abrogated the deleterious effects of miR-20b on CH. +circulation_biomarker_diagnosis_ns 31465536 hsa-mir-494 Ischemic Stroke EXPERIMENTAL APPROACH: MiR-494 levels in blood from AIS patients and controls were measured by real-time PCR. +lncRNA target 31465316 hsa-mir-665 Precursor Cell Lymphoblastic Leukemia-Lymphoma Our study showed that EXT1 modulates the proliferation and apoptosis of ALL cells in vitro and in vivo and that miR-665 promotes cell growth and inhibits apoptosis by suppressing EXT1. +genetics_GWAS 31464930 hsa-mir-146a Brain Neoplasms CONCLUSION: Our study suggests that miR-146a polymorphism may modify the risk for brain tumors, but which type (glioma or benign non-glioma tumors) should be verified with large sample size. +lncRNA target 31464068 hsa-mir-576 Esophageal Squamous Cell Carcinoma In conclusion, linc-PINT-miR-543/miR5p pathway could predict the prognosis and provide novel therapeutic targets for esophageal cancer. +lncRNA target 31464068 hsa-mir-543 Esophageal Squamous Cell Carcinoma In conclusion, linc-PINT-miR-543/miR5p pathway could predict the prognosis and provide novel therapeutic targets for esophageal cancer. +circulation_biomarker_diagnosis_ns 31463641 hsa-mir-335 Carcinoma, Non-Small-Cell Lung The presence of changes observed in the expression level of miR-335 and miR let-7a in the serum of NSCLC patients in relation to lymph node metastases and tumor stage may serve as a non-invasive molecular biomarker of tumor progression; however, this observation requires further investigation. +circulation_biomarker_diagnosis_ns 31463641 hsa-let-7a Carcinoma, Non-Small-Cell Lung The presence of changes observed in the expression level of miR-335 and miR let-7a in the serum of NSCLC patients in relation to lymph node metastases and tumor stage may serve as a non-invasive molecular biomarker of tumor progression; however, this observation requires further investigation. +circulation_biomarker_diagnosis_down 31463135 hsa-mir-181a-2 Inflammation 3p in the serum of COPD patients and further investigated the role of miR-181a +circulation_biomarker_diagnosis_down 31463135 hsa-mir-181a-2 Pulmonary Disease, Chronic Obstructive 3p in the serum of COPD patients and further investigated the role of miR-181a +transcription factor target 31463135 hsa-mir-181a-2 Pneumonia CONCLUSIONS: Our results strongly suggest that miR-181a3p has a critical role in Cd-induced inflammation of airway by regulating its potential target genes, which could be molecular targets for COPD. +circulation_biomarker_diagnosis_down 31463135 hsa-mir-181a Pulmonary Disease, Chronic Obstructive 3p in the serum of COPD patients and further investigated the role of miR-181a +circulation_biomarker_diagnosis_down 31463135 hsa-mir-181a Inflammation 3p in the serum of COPD patients and further investigated the role of miR-181a +transcription factor target 31463135 hsa-mir-181a Pneumonia CONCLUSIONS: Our results strongly suggest that miR-181a3p has a critical role in Cd-induced inflammation of airway by regulating its potential target genes, which could be molecular targets for COPD. +other 31462944 hsa-mir-155 Ovarian Neoplasms RESULTS: An lncRNA-based co-expression module was significantly correlated with patient age at initial pathologic diagnosis, lymphatic invasion, tissues source site, and vascular invasion, and identified 16 lncRNAs (ACTA2-AS1, CARD8-AS1, HCP5, HHIP-AS1, HOTAIRM1, ITGB2-AS1, LINC00324, LINC00605, LINC01503, LINC01547, MIR31HG, MIR155HG, OTUD6B-AS1, PSMG3-AS1, SH3PXD2A-AS1, and ZBED5-AS1) that were significantly related to overall survival in OC patients. +other 31462944 hsa-mir-1 Ovarian Neoplasms RESULTS: An lncRNA-based co-expression module was significantly correlated with patient age at initial pathologic diagnosis, lymphatic invasion, tissues source site, and vascular invasion, and identified 16 lncRNAs (ACTA2-AS1, CARD8-AS1, HCP5, HHIP-AS1, HOTAIRM1, ITGB2-AS1, LINC00324, LINC00605, LINC01503, LINC01547, MIR31HG, MIR155HG, OTUD6B-AS1, PSMG3-AS1, SH3PXD2A-AS1, and ZBED5-AS1) that were significantly related to overall survival in OC patients. +transcription factor target 31462892 hsa-mir-21 Carcinoma, Non-Small-Cell Lung Furthermore, down-regulation of CD36 suppressed miR-21 regulated cell growth, migration and intracellular contents of lipids in human non-small cell lung cancer cells, which suggested that miR-21 promoted cell growth and migration of human non-small cell lung cancer cells through CD36 mediated fatty acid metabolism. +genetics_overexpression_promote 31462890 hsa-mir-23a Melanoma In addition, the overexpression of KLF3 could lower the effects of miR-23a-3p caused on melanoma cancer cell development. +lncRNA target 31462285 hsa-mir-627 Glioblastoma Subsequently, using bioinformatics tool, a potential mechanistic route for SNHG15 to promote GBM tumorigenesis was by inhibiting tumor suppressor, miR +lncRNA target 31462285 hsa-mir-627 Glioma Subsequently, using bioinformatics tool, a potential mechanistic route for SNHG15 to promote GBM tumorigenesis was by inhibiting tumor suppressor, miR +lncRNA target 31461554 hsa-mir-140 Bowen-Conradi syndrome 5p might play a role in this process through targeting Bloc1s2. +other 31460867 hsa-mir-27a Osteoarthritis As compared to their levels in normal cells and tissues, miR-27a expression was found to be upregulated in OA cartilage and IL-1beta-treated articular chondrocytes. This study demonstrated miR-27a is a regulator of the PI3K-Akt-mTOR axis in human chondrocytes and could participate in OA pathogenesis. +transcription factor target 31460837 hsa-mir-1306 Reperfusion Injury, Cerebral Ischemia Our findings thus provide an experimental basis miR5p targeting BIK-based therapy for cerebral I/R injury. +transcription factor target 31460781 hsa-mir-148b Atopic Asthma The dysregulation of TNF, HLA-DPA1, and miR-148b might be related to the immune response of childhood atopic asthma. +other 31460540 hsa-mir-21 Breast Neoplasms As a proof of concept, the simultaneous detection of two breast cancer-related MicroRNAs (miR-21 and let-7a miRNA) has been achieved with total internal reflection fluorescence (TIRF)-based imaging and the detection sensitivity of our method has been demonstrated to be improved by at least two orders of magnitude compared with conventional AgNC-MBs. +other 31460540 hsa-let-7a Breast Neoplasms As a proof of concept, the simultaneous detection of two breast cancer-related MicroRNAs (miR-21 and let-7a miRNA) has been achieved with total internal reflection fluorescence (TIRF)-based imaging and the detection sensitivity of our method has been demonstrated to be improved by at least two orders of magnitude compared with conventional AgNC-MBs. +lncRNA target 31456594 hsa-mir-92 Glioblastoma CONCLUSIONS Our results demonstrate that circMTO1 inhibits the proliferation of glioblastoma cells via the miR-92/WWOX signaling pathway. +lncRNA target 31456514 hsa-mir-155 Parkinson Disease Notably, inhibition of miR- 155 or PIC receptors largely recovered the impaired learning performance in AD rat. +lncRNA target 31456514 hsa-mir-155 Alzheimer Disease Notably, inhibition of miR- 155 or PIC receptors largely recovered the impaired learning performance in AD rat. +genetics_overexpression_promote 31456452 hsa-mir-103 Carcinoma, Endometrioid Overexpression of miR-103 significantly promoted EC cell proliferation, while downregulation of miR-103 significantly suppressed EC cell proliferation. +genetics_overexpression_promote 31456112 hsa-mir-4458 Triple Negative Breast Neoplasms In conclusion, HEIH functions as an oncogenic lncRNA that is overexpressed in TNBC and associated with clinical progression, and regulates TNBC cell proliferation and apoptosis through miR-4458/SOCS1 axis. +lncRNA target 31455760 hsa-mir-490 Urinary Bladder Neoplasms 5p/EGFR signaling pathway suppressed BCa progression. +transcription factor target 31455266 hsa-mir-607 Renal Insufficiency, Chronic 3p may represent as promising therapeutic targets against kidney fibrosis. +transcription factor target 31455266 hsa-mir-4709 Renal Insufficiency, Chronic 3p may represent as promising therapeutic targets against kidney fibrosis. +other 31455213 hsa-mir-423 Hyperplasia BACKGROUND: A study has shown that miR5p is highly expressed in proliferative diabetic retinopathy. +other 31455213 hsa-mir-423 Diabetic Retinopathy 5p in diabetic retinopathy (DR) progression are currently unclear. +circulation_biomarker_diagnosis_ns 31455213 hsa-mir-423 Duane Retraction Syndrome 5p is significantly increased in HG-induced RPE cells and DR patient plasma. +genetics_overexpression_suppress 31454494 hsa-mir-508 Uterine Cervical Neoplasms Furthermore, the expression levels of Linc00483 was positively correlated with RGS17 in the clinical samples and overexpressed Linc00483 increased RGS17 expression levels in cervical cancer cells by sponging miR +genetics_GWAS 31453981 hsa-mir-214 Neuralgia Together, our data indicate that the DNMT3a-mediated epigenetic suppression of miR +other 31453710 hsa-mir-200c Hypertension, Pregnancy-Induced Furthermore, fetal livers from MHC mothers showed increased miRNA-27a and reduced miRNA-200c expression. +other 31453710 hsa-mir-27a Hypertension, Pregnancy-Induced Furthermore, fetal livers from MHC mothers showed increased miRNA-27a and reduced miRNA-200c expression. +circulation_biomarker_prognosis_up 31452818 hsa-mir-96 Carcinoma, Hepatocellular Receiver operating characteristics (ROC) curve analysis revealed that circulating miR-155, miR-96, miR-99a and a combination of these three miRNAs could serve as diagnostic biomarkers for HCC with areas under the curve (AUC) of 0.84, 0.824, 0.799 and 0.931, respectively. +circulation_biomarker_prognosis_up 31452818 hsa-mir-155 Carcinoma, Hepatocellular Receiver operating characteristics (ROC) curve analysis revealed that circulating miR-155, miR-96, miR-99a and a combination of these three miRNAs could serve as diagnostic biomarkers for HCC with areas under the curve (AUC) of 0.84, 0.824, 0.799 and 0.931, respectively. +genetics_overexpression_promote 31452816 hsa-mir-21 Leukemia, Myeloid, Acute In addition, miR-21 overexpression promoted the proliferation of AML cells in vitro. +genetics_overexpression_promote 31452813 hsa-mir-106b Osteosarcoma Taken together, this study's results indicated that the overexpression of miR-106b is associated with a poor prognosis for patients with OS and that overexpression promotes OS cell proliferation, migration, and invasion. +genetics_overexpression_suppress 31452812 hsa-mir-21 Colorectal Neoplasms In CRC cells in vitro, miR-21 overexpression failed to significantly affect DGCR5, while DGCR5 overexpression resulted in reduced expression levels of miR-21. Therefore, lncRNA DGCR5 may inhibit the proliferation of CRC cells by downregulating miR-21. +genetics_overexpression_promote 31452811 hsa-mir-520a Stomach Neoplasms Furthermore, overexpression of miR-520a-3p significantly inhibited cell proliferation, invasion and migration in SGC-7901 and MGC-803 GC cell lines using proliferation, wound healing and cell invasion assays. +lncRNA target 31452805 hsa-mir-200c Colorectal Neoplasms Collectively, the present study suggested that inhibition of CRC cell invasion by UA occurred via regulation of the TGF-beta1/ZEB1/miR-200c signaling network, which may be one of the mechanisms by which UA appears to be an effective therapeutic agent against colon cancer. +transcription factor target 31452793 hsa-mir-490 Esophageal Neoplasms 3p may therefore promote the proliferation and inhibit the apoptosis of ESCC cells by regulating MAPK1. +genetics_overexpression_suppress 31452787 hsa-mir-761 Stomach Neoplasms Simultaneously, overexpression of RIN1 partially rescued the inhibitory effect of miR-761 mimic in the GC cells. +other 31452786 hsa-mir-1 Colorectal Neoplasms The expression levels of miR-27a and miR-31 are related to distant metastasis and tumor grade of patients with colorectal cancer, and positively associated with the survival time of patients, having high diagnostic value. +other 31452786 hsa-mir-27a Colorectal Neoplasms Histological type of patients with non-mucinous carcinoma had increased relative expression levels of miR-27a and miR-31 in comparison with those with mucinous carcinoma (P<0.05). +genetics_overexpression_promote 31452774 hsa-mir-545 Carcinoma, Non-Small-Cell Lung The overexpression of miR-545 suppressed the migration, invasion and proliferation of NSCLC cells. +lncRNA target 31452770 hsa-mir-16 Carcinoma, Non-Small-Cell Lung Taken together, the results demonstrate that miR-16 may serve as an effective chemosensitizing target to enhance the effects of chemotherapy in drug-resistant BC cells with high Wip1 and Bcl-2 expression. +lncRNA target 31452770 hsa-mir-16 Breast Neoplasms Taken together, the results demonstrate that miR-16 may serve as an effective chemosensitizing target to enhance the effects of chemotherapy in drug-resistant BC cells with high Wip1 and Bcl-2 expression. +lncRNA target 31452740 hsa-mir-744 Osteosarcoma Moreover, upregulation of LATS2 weakened the promotion of cell viability and metastasis induced by miR-744 in OS. +lncRNA target 31452731 hsa-mir-616 Breast Neoplasms In conclusion, the present data suggested that the miR-616/TIMP2/MMPs axis may serve an important role in the progression of breast cancer and may be a potential therapeutic target for this disease. +genetics_overexpression_suppress 31452724 hsa-mir-589 Breast Neoplasms Furthermore, miR-589 overexpression decreased the TNBC cell proliferation, migration and invasion, whereas miR-589 silencing generated the opposite results in vitro. +genetics_overexpression_promote 31452272 hsa-mir-758 Leukemia, Myeloid, Acute 3p suppression and SRGN overexpression could mitigate the inhibitory effects of SNHG3 depletion on AML cell growth. +other 31452264 hsa-mir-196a-2 Osteoporosis Previously, microRNA-196a-2 (miR-196a-2) and miR-196a-3p were reported for its involvement in BMD. +other 31452262 hsa-mir-204 Stomach Neoplasms AS1, TLR8-AS1, and VCAN-AS1). +lncRNA target 31452245 hsa-mir-661 Ovarian Neoplasms The results collectively indicated that circPIP5K1A contributed to ovarian cancer progression via targeting the miR-661/IGFBP5 axis, supporting its utility as a candidate target for therapy of the disease. +lncRNA target 31452245 hsa-mir-66 Ovarian Neoplasms The results collectively indicated that circPIP5K1A contributed to ovarian cancer progression via targeting the miR-661/IGFBP5 axis, supporting its utility as a candidate target for therapy of the disease. +transcription factor target 31452243 hsa-mir-605 Carcinoma, Non-Small-Cell Lung 5p promotes invasion and proliferation by targeting TNFAIP3 in NSCLC, and may provide possible biomarkers for NSCLC therapy. +transcription factor target 31452174 hsa-mir-20a Glioblastoma Our results suggest that miR3p and miR-20a-5p may serve as new therapeutic targets for the treatment of glioblastoma. +transcription factor target 31452174 hsa-mir-17 Glioblastoma Our results suggest that miR3p and miR-20a-5p may serve as new therapeutic targets for the treatment of glioblastoma. +transcription factor target 31452083 hsa-mir-532 Multiple Myeloma miR-532 promotes cell proliferation and invasion in t(4;14) MMs by targeting CAMK2N1. +other 31452017 hsa-mir-27a Bronchiolitis Obliterans MiR-27a-3p may also be developed as a new drug for the OB therapy. +lncRNA target 31451992 hsa-mir-22 Stomach Neoplasms CONCLUSION: CTC-497E21.4 competed with miR-22 to regulate the expression of NET1 and regulated the malignant progression of GC through RhoA signaling pathway. +lncRNA target 31451219 hsa-mir-20a Osteoarthritis In conclusion, the results demonstrate an increase in articular cavity inflammation in rats with OA in the presence of miR-20a by targeting on IkappaBbeta and activating the NF-kappaB signaling pathway. +circulation_biomarker_diagnosis_ns 31450959 hsa-mir-130a Ischemic Stroke More importantly, we determined serum exosomal miR-125b-5p, miR +circulation_biomarker_diagnosis_ns 31450959 hsa-mir-152 Ischemic Stroke More importantly, we determined serum exosomal miR-125b-5p, miR +circulation_biomarker_diagnosis_ns 31450959 hsa-mir-152 Spinal Cord Injuries More importantly, we determined serum exosomal miR-125b-5p, miR +circulation_biomarker_diagnosis_ns 31450959 hsa-mir-125b Ischemic Stroke More importantly, we determined serum exosomal miR-125b-5p, miR +circulation_biomarker_diagnosis_ns 31450959 hsa-mir-125b Spinal Cord Injuries More importantly, we determined serum exosomal miR-125b-5p, miR +circulation_biomarker_diagnosis_ns 31450959 hsa-mir-130a Spinal Cord Injuries More importantly, we determined serum exosomal miR-125b-5p, miR +other 31450927 hsa-mir-224 Carcinoma, Hepatocellular Conclusion: miRNA-122 and miRNA-224 could serve as biomarkers for the diagnosis of HCC. +other 31450927 hsa-mir-122 Carcinoma, Hepatocellular Conclusion: miRNA-122 and miRNA-224 could serve as biomarkers for the diagnosis of HCC. +other 31450927 hsa-mir-224 Hepatitis C, Chronic Conclusion: miRNA-122 and miRNA-224 could serve as biomarkers for the diagnosis of HCC. +other 31450927 hsa-mir-122 Hepatitis C, Chronic Conclusion: miRNA-122 and miRNA-224 could serve as biomarkers for the diagnosis of HCC. +other 31450920 hsa-mir-9 Uterine Cervical Neoplasms In this study, we have investigated the effect of Escherichia coli O111:B4 Lipopolysaccharide (LPS) on HPV positive cell line (HeLa), the expression level of the (Snail, E-cadherin, and ZEB-1), HPV oncogenes (E6, E7) and also microRNA-9, 192. +genetics_overexpression_promote 31450568 hsa-mir-34a Retinoblastoma Moreover, miR-34a overexpression increases sensitivity of Y79 cells towards RB chemotherapeutics, however, without involvement of EMP1. In summary, the TFF3 signaling pathway in Y79 RB cells involves the activation of p53 with downstream induction of miR-34a and subsequent inhibition of EMP1. +circulation_biomarker_diagnosis_ns 31450503 hsa-mir-199a Alzheimer Disease METHODS: Blood samples from 40 AD patients and 29 age-matched HC were included for determination of 78 parameter by blood counting, platelet morphometry, aggregometry, flow cytometry (CD62P, CD63, activated fibrinogen receptor), protein quantification of nicotinic acetylcholine receptor alpha7 (nAChRalpha7) and caveolin-1 (CAV-1), and miRNA quantification (miR-26b, miR-199a, miR-335). +circulation_biomarker_diagnosis_ns 31450503 hsa-mir-26b Alzheimer Disease METHODS: Blood samples from 40 AD patients and 29 age-matched HC were included for determination of 78 parameter by blood counting, platelet morphometry, aggregometry, flow cytometry (CD62P, CD63, activated fibrinogen receptor), protein quantification of nicotinic acetylcholine receptor alpha7 (nAChRalpha7) and caveolin-1 (CAV-1), and miRNA quantification (miR-26b, miR-199a, miR-335). +circulation_biomarker_diagnosis_ns 31450503 hsa-mir-335 Alzheimer Disease METHODS: Blood samples from 40 AD patients and 29 age-matched HC were included for determination of 78 parameter by blood counting, platelet morphometry, aggregometry, flow cytometry (CD62P, CD63, activated fibrinogen receptor), protein quantification of nicotinic acetylcholine receptor alpha7 (nAChRalpha7) and caveolin-1 (CAV-1), and miRNA quantification (miR-26b, miR-199a, miR-335). +other 31449822 hsa-mir-20 Vascular Diseases miR-320/VEGFA axis affects high glucose-induced metabolic memory during human umbilical vein endothelial cell dysfunction in diabetes pathology. In conclusion, we demonstrate that miR-320/VEGFA axis is crucial to high glucose-induced metabolic memory during HUVEC dysfunction and may be involved in the pathology of diabetes. +other 31449822 hsa-mir-20 Diabetes Mellitus miR-320/VEGFA axis affects high glucose-induced metabolic memory during human umbilical vein endothelial cell dysfunction in diabetes pathology. In conclusion, we demonstrate that miR-320/VEGFA axis is crucial to high glucose-induced metabolic memory during HUVEC dysfunction and may be involved in the pathology of diabetes. +other 31448843 hsa-mir-202 Hoyeraal Hreidarsson syndrome We identified hsa-miR5p as a potential negative regulator of PARN. +lncRNA target 31448575 hsa-mir-181 Colorectal Neoplasms In addition, the protein-protein interaction (PPI) networks were set up by miR-181 targets to screen hub nodes and significant modules, which were also considerably associated with the molecular pathogenesis of CRC. +other 31448543 hsa-mir-199a Autoimmune Diseases miR-199a-3p over-expression may therefore be a potential therapeutic strategy for use in organ transplantation or patients with autoimmune diseases. +lncRNA target 31448245 hsa-mir-374b Encephalitis, Japanese JEV infection modulated the expression of hsa-miR-374b-5p and PI3K/AKT pathway via PTEN. +other 31448232 hsa-mir-1-1 Urinary Bladder Neoplasms 1, mir-133b, mir-20a, mir-185, mir-19a, mir-19b-2, mir-19b-1, mir-17, mir-15a, and mir-133a-2 were demonstrated to be significantly correlated with the overall survival (OS) of bladder cancer patients using Kaplan-Meier survival analysis and Log-rank test. +other 31448232 hsa-mir-19b-2 Urinary Bladder Neoplasms 1, mir-133b, mir-20a, mir-185, mir-19a, mir-19b-2, mir-19b-1, mir-17, mir-15a, and mir-133a-2 were demonstrated to be significantly correlated with the overall survival (OS) of bladder cancer patients using Kaplan-Meier survival analysis and Log-rank test. +other 31448232 hsa-mir-490 Urinary Bladder Neoplasms 1, mir-133b, mir-20a, mir-185, mir-19a, mir-19b-2, mir-19b-1, mir-17, mir-15a, and mir-133a-2 were demonstrated to be significantly correlated with the overall survival (OS) of bladder cancer patients using Kaplan-Meier survival analysis and Log-rank test. +other 31448232 hsa-mir-20a Urinary Bladder Neoplasms 1, mir-133b, mir-20a, mir-185, mir-19a, mir-19b-2, mir-19b-1, mir-17, mir-15a, and mir-133a-2 were demonstrated to be significantly correlated with the overall survival (OS) of bladder cancer patients using Kaplan-Meier survival analysis and Log-rank test. +other 31448232 hsa-let-7c Urinary Bladder Neoplasms 1, mir-133b, mir-20a, mir-185, mir-19a, mir-19b-2, mir-19b-1, mir-17, mir-15a, and mir-133a-2 were demonstrated to be significantly correlated with the overall survival (OS) of bladder cancer patients using Kaplan-Meier survival analysis and Log-rank test. +other 31448232 hsa-mir-200c Urinary Bladder Neoplasms 1, mir-133b, mir-20a, mir-185, mir-19a, mir-19b-2, mir-19b-1, mir-17, mir-15a, and mir-133a-2 were demonstrated to be significantly correlated with the overall survival (OS) of bladder cancer patients using Kaplan-Meier survival analysis and Log-rank test. +other 31448232 hsa-mir-15a Urinary Bladder Neoplasms 1, mir-133b, mir-20a, mir-185, mir-19a, mir-19b-2, mir-19b-1, mir-17, mir-15a, and mir-133a-2 were demonstrated to be significantly correlated with the overall survival (OS) of bladder cancer patients using Kaplan-Meier survival analysis and Log-rank test. +other 31448232 hsa-mir-93 Urinary Bladder Neoplasms 1, mir-133b, mir-20a, mir-185, mir-19a, mir-19b-2, mir-19b-1, mir-17, mir-15a, and mir-133a-2 were demonstrated to be significantly correlated with the overall survival (OS) of bladder cancer patients using Kaplan-Meier survival analysis and Log-rank test. +other 31448232 hsa-mir-133a-1 Urinary Bladder Neoplasms 1, mir-133b, mir-20a, mir-185, mir-19a, mir-19b-2, mir-19b-1, mir-17, mir-15a, and mir-133a-2 were demonstrated to be significantly correlated with the overall survival (OS) of bladder cancer patients using Kaplan-Meier survival analysis and Log-rank test. +other 31448232 hsa-mir-17 Urinary Bladder Neoplasms 1, mir-133b, mir-20a, mir-185, mir-19a, mir-19b-2, mir-19b-1, mir-17, mir-15a, and mir-133a-2 were demonstrated to be significantly correlated with the overall survival (OS) of bladder cancer patients using Kaplan-Meier survival analysis and Log-rank test. +other 31448232 hsa-mir-185 Urinary Bladder Neoplasms 1, mir-133b, mir-20a, mir-185, mir-19a, mir-19b-2, mir-19b-1, mir-17, mir-15a, and mir-133a-2 were demonstrated to be significantly correlated with the overall survival (OS) of bladder cancer patients using Kaplan-Meier survival analysis and Log-rank test. +other 31448232 hsa-mir-944 Urinary Bladder Neoplasms 1, mir-133b, mir-20a, mir-185, mir-19a, mir-19b-2, mir-19b-1, mir-17, mir-15a, and mir-133a-2 were demonstrated to be significantly correlated with the overall survival (OS) of bladder cancer patients using Kaplan-Meier survival analysis and Log-rank test. +other 31448232 hsa-mir-590 Urinary Bladder Neoplasms 1, mir-133b, mir-20a, mir-185, mir-19a, mir-19b-2, mir-19b-1, mir-17, mir-15a, and mir-133a-2 were demonstrated to be significantly correlated with the overall survival (OS) of bladder cancer patients using Kaplan-Meier survival analysis and Log-rank test. +other 31448232 hsa-mir-1-2 Urinary Bladder Neoplasms 1, mir-133b, mir-20a, mir-185, mir-19a, mir-19b-2, mir-19b-1, mir-17, mir-15a, and mir-133a-2 were demonstrated to be significantly correlated with the overall survival (OS) of bladder cancer patients using Kaplan-Meier survival analysis and Log-rank test. +other 31448232 hsa-mir-133b Urinary Bladder Neoplasms 1, mir-133b, mir-20a, mir-185, mir-19a, mir-19b-2, mir-19b-1, mir-17, mir-15a, and mir-133a-2 were demonstrated to be significantly correlated with the overall survival (OS) of bladder cancer patients using Kaplan-Meier survival analysis and Log-rank test. +other 31448232 hsa-mir-19b-1 Urinary Bladder Neoplasms 1, mir-133b, mir-20a, mir-185, mir-19a, mir-19b-2, mir-19b-1, mir-17, mir-15a, and mir-133a-2 were demonstrated to be significantly correlated with the overall survival (OS) of bladder cancer patients using Kaplan-Meier survival analysis and Log-rank test. +other 31448232 hsa-mir-133a-2 Urinary Bladder Neoplasms 1, mir-133b, mir-20a, mir-185, mir-19a, mir-19b-2, mir-19b-1, mir-17, mir-15a, and mir-133a-2 were demonstrated to be significantly correlated with the overall survival (OS) of bladder cancer patients using Kaplan-Meier survival analysis and Log-rank test. +other 31448232 hsa-mir-19a Urinary Bladder Neoplasms 1, mir-133b, mir-20a, mir-185, mir-19a, mir-19b-2, mir-19b-1, mir-17, mir-15a, and mir-133a-2 were demonstrated to be significantly correlated with the overall survival (OS) of bladder cancer patients using Kaplan-Meier survival analysis and Log-rank test. +other 31448232 hsa-mir-143 Urinary Bladder Neoplasms 1, mir-133b, mir-20a, mir-185, mir-19a, mir-19b-2, mir-19b-1, mir-17, mir-15a, and mir-133a-2 were demonstrated to be significantly correlated with the overall survival (OS) of bladder cancer patients using Kaplan-Meier survival analysis and Log-rank test. +other 31448232 hsa-mir-141 Urinary Bladder Neoplasms 1, mir-133b, mir-20a, mir-185, mir-19a, mir-19b-2, mir-19b-1, mir-17, mir-15a, and mir-133a-2 were demonstrated to be significantly correlated with the overall survival (OS) of bladder cancer patients using Kaplan-Meier survival analysis and Log-rank test. +other 31448232 hsa-mir-192 Urinary Bladder Neoplasms 1, mir-133b, mir-20a, mir-185, mir-19a, mir-19b-2, mir-19b-1, mir-17, mir-15a, and mir-133a-2 were demonstrated to be significantly correlated with the overall survival (OS) of bladder cancer patients using Kaplan-Meier survival analysis and Log-rank test. +other 31448068 hsa-mir-150 Colonic Neoplasms 3p for further validation in an independent cohort consisting of 134 participants (58 CC and 76 NC). +other 31448068 hsa-mir-139 Colonic Neoplasms 3p for further validation in an independent cohort consisting of 134 participants (58 CC and 76 NC). +other 31448068 hsa-mir-145 Colonic Neoplasms 3p for further validation in an independent cohort consisting of 134 participants (58 CC and 76 NC). +other 31448068 hsa-let-7b Colonic Neoplasms 3p for further validation in an independent cohort consisting of 134 participants (58 CC and 76 NC). +lncRNA target 31448054 hsa-mir-34a Cystadenocarcinoma, Serous, Ovarian Additionally, we evaluated the viability of miR-34a as a therapeutic application for HGSC both in vitro and in vivo. +circulation_biomarker_diagnosis_ns 31447785 hsa-mir-154 Diabetes Mellitus, Type 2 Conclusion: These findings suggested that increased serum levels of miR5p and decreased OC levels may influence osteogenesis and proteinuria in T2DM and may identify novel targets for diagnosis and treatment of diabetic kidney disease and osteoporosis. +lncRNA target 31447563 hsa-mir-495 Osteosarcoma 3p may act as a tumor suppressor and an underlying target for OS treatment. +transcription factor target 31447353 hsa-mir-34a Obesity In addition, these genes are targeted by miRNAs related to schizophrenia (mir-34a) and obesity (mir-19b). +transcription factor target 31447353 hsa-mir-19b Schizophrenia In addition, these genes are targeted by miRNAs related to schizophrenia (mir-34a) and obesity (mir-19b). +transcription factor target 31447353 hsa-mir-19b Obesity In addition, these genes are targeted by miRNAs related to schizophrenia (mir-34a) and obesity (mir-19b). +transcription factor target 31447353 hsa-mir-34a Schizophrenia In addition, these genes are targeted by miRNAs related to schizophrenia (mir-34a) and obesity (mir-19b). +genetics_knock down_suppress 31447119 hsa-mir-137 Alzheimer Disease In summary, our result indicated that knockdown of SNHG1 exerted its neuronal protective effects via repressing KRENEN1 by acting as a ceRNA for miR-137 in the in vitro cell model of AD. +genetics_overexpression_promote 31446795 hsa-mir-34c Osteosarcoma Overexpression of FLOT2 reversed the inhibitory effect of miR-34c-5p overexpression on proliferation, migration and invasion of osteosarcoma cell lines. +other 31446120 hsa-mir-146a Osteoarthritis 3p, or miR-146a prior to stimulation with interleukin-1 beta and tumor factor necrosis-alpha as an inflammatory model of OA, each of these microRNAs exhibited similar protective effects. +circulation_biomarker_diagnosis_down 31446056 hsa-mir-626 Macular Degeneration At last, we show that plasma miR-626 levels are significantly downregulated in age-related macular degeneration (AMD) patients than those in the healthy donors. +other 31445716 hsa-mir-433 Carcinoma, Non-Small-Cell Lung miR-433 may be a candidate worth further exploration for its prognostic and therapeutic potential in NSCLC. +genetics_knock down_promote 31445715 hsa-mir-421 Carcinoma, Non-Small-Cell Lung The migratory and invasive abilities of NSCLC cells were also attenuated following miR-421 knockdown. +genetics_overexpression_suppress 31445025 hsa-mir-498 Uterine Cervical Neoplasms BMI-1 overexpression reversed the effects of hsa_circ_0007534 depletion or miR-498 overexpression on cervical cancer cell proliferation and invasion. +lncRNA target 31444971 hsa-mir-205 Stomach Neoplasms 5p was associated with tumor stage, and in SGC-7901 cells PTEN was a target gene for miR +other 31444671 hsa-mir-20a familial febrile seizures 1 In summary, this study highlighted the relieved potential of miR-20a against cardiomyocyte H/R injury and suggested its favorable therapeutic role for myocardial I/R injury. +transcription factor target 31444414 hsa-mir-129 Breast Neoplasms To conclude, NONHSAT101069 was upregulated in BC tissues and promoted epirubicin resistance, migration and invasion of BC cells via regulation of NONHSAT101069/miR +genetics_GWAS 31444373 hsa-mir-181a Lupus Erythematosus, Systemic We investigated whether MTMR3 SNP rs12537 in the miR-181a-binding site is associated with the susceptibility and progression of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). +genetics_GWAS 31444373 hsa-mir-181a Arthritis, Rheumatoid We investigated whether MTMR3 SNP rs12537 in the miR-181a-binding site is associated with the susceptibility and progression of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). +genetics_overexpression_suppress 31443963 hsa-mir-143 Squamous Cell Carcinoma of Head and Neck Forced overexpression of miR +transcription factor target 31443378 hsa-mir-34a Mitochondrial Diseases Transfection of the cells with miR-34a inhibitor (IB) halted HG-induced mitochondrial dysfunction and up-regulation of senescence-associated markers, whereas miR-34a mimic promoted cellular senescence and mitochondrial dysfunction. +other 31443224 hsa-mir-877 Cholangiocarcinoma The validation phase confirmed downregulated miR-16 in patients with distal CCA compared to benign disease or PDAC (P = 0.048 and P = 0.012), while miR-877 was significantly upregulated (P = 0.003 and P = 0.006). +other 31443224 hsa-mir-16 Cholangiocarcinoma The validation phase confirmed downregulated miR-16 in patients with distal CCA compared to benign disease or PDAC (P = 0.048 and P = 0.012), while miR-877 was significantly upregulated (P = 0.003 and P = 0.006). +lncRNA target 31442551 hsa-mir-185 Squamous Cell Carcinoma of Head and Neck SIGNIFICANCE: Taken together, the findings in this research reveal the modulation of LINC00958 for the OSCC tumorigenesis through the miR5p/YWHAZ axis, which might be useful for the mechanical investigation associated with OSCC therapeutic target. +genetics_overexpression_promote 31441682 hsa-mir-92a Adenomatous Polyposis Coli O-glycoside compared with the control without treatment (P < .05); in contrast, the tumor suppressor genes AMPK (4.85, P=.005) and APC (2.71, P=.066) tumor suppressors genes were overexpressed. +genetics_knock down_suppress 31441682 hsa-mir-92a Colonic Neoplasms O-glycoside on the expression of oncological biomarkers, miR31 and miR92a in a colon cancer cell line (RKO) were analyzed. +genetics_knock down_suppress 31441682 hsa-mir-1 Colonic Neoplasms O-glycoside on the expression of oncological biomarkers, miR31 and miR92a in a colon cancer cell line (RKO) were analyzed. +genetics_overexpression_promote 31441682 hsa-mir-1 Adenomatous Polyposis Coli O-glycoside compared with the control without treatment (P < .05); in contrast, the tumor suppressor genes AMPK (4.85, P=.005) and APC (2.71, P=.066) tumor suppressors genes were overexpressed. +other 31441412 hsa-mir-17 Acute Lung Injury 0.48+/-0.13, P < 0.05), indicating that the improvement of Xuebijing injection on lung injury after CPB might be related to miR5p. +lncRNA target 31441410 hsa-mir-181b Sepsis Up-regulation of miR-181b could inhibit the activation of NF-KappaB signal pathway and the release of the inflammatory cytokine IL-1beta and TNF-alpha stimulated by sepsis, and alleviate the inflammatory reaction and hippocampus injury in rat with sepsis. +transcription factor target 31441360 hsa-mir-181c Lymphoma, Extranodal NK-T-Cell miR-34a and miR-181c may be involved in the oncogenic progression of NKTCL through the regulation of PDGFRalpha, STAT3, and K-RAS. +transcription factor target 31441360 hsa-mir-34a Lymphoma, Extranodal NK-T-Cell miR-34a and miR-181c may be involved in the oncogenic progression of NKTCL through the regulation of PDGFRalpha, STAT3, and K-RAS. +other 31441344 hsa-mir-16 Scleroderma, Systemic 5p with survivin-TS mRNA expression.Conclusion: Survivin variants had altered expression in total-SSc patients. +other 31441344 hsa-mir-150 Scleroderma, Systemic 5p with survivin-TS mRNA expression.Conclusion: Survivin variants had altered expression in total-SSc patients. +other 31441344 hsa-mir-485 Scleroderma, Systemic 5p with survivin-TS mRNA expression.Conclusion: Survivin variants had altered expression in total-SSc patients. +lncRNA target 31441000 hsa-mir-146b Stomach Neoplasms The re-introduction of PTP1B reversed the growth inhibition and apoptosis of gastric cancer cells induced by miR-146b. +genetics_overexpression_promote 31440867 hsa-mir-15a Carcinoma, Renal Cell Overexpression of miR-15a was strongly associated with poor histologic prognostic features of ccRCC. +genetics_overexpression_promote 31440087 hsa-mir-216a Colorectal Neoplasms Moreover, the overexpression of miR-216a-5p could significantly inhibit the tumor growth, metastasis, and EMT progression in CRC. +genetics_overexpression_promote 31440062 hsa-mir-203 Stomach Neoplasms Moreover, overexpression of miR-203 decreased survival fraction, cell viability and tumor growth but promoted cell apoptosis in radiation-treated GC cells. +lncRNA target 31440033 hsa-mir-23b Osteoarthritis CONCLUSION: Downregulation of miR-23b-3p could alleviate the progression of OA through upregulating COL11A2 in vivo and in vitro. +lncRNA target 31440033 hsa-mir-23b Cartilage Diseases Moreover, downregulation of miR-23b-3p alleviated synovitis/cartilage destruction and reduced Osteoarthritis Research Society International scores and subchondral bone thickness in vivo. +transcription factor target 31440033 hsa-mir-23b Lissencephaly RESULTS: The levels of miR-23b-3p were upregulated, while the expressions of collagen II and aggrecan were decreased in OA tissues and in IL-1beta-treated CHON-001 cells. However, downregulation of miR-23b-3p markedly inhibited IL-1beta-induced apoptosis in CHON-001 cells via increasing the collagen II and aggrecan levels and decreasing Bax and active caspase 3 expressions. +lncRNA target 31440033 hsa-mir-23b Synovitis Moreover, downregulation of miR-23b-3p alleviated synovitis/cartilage destruction and reduced Osteoarthritis Research Society International scores and subchondral bone thickness in vivo. +transcription factor target 31439976 hsa-mir-497 Arthritis, Rheumatoid 5p can be considered critical targets for further studies on future therapeutic attempts for the treatment of autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. +transcription factor target 31439976 hsa-mir-497 Autoimmune Diseases 5p can be considered critical targets for further studies on future therapeutic attempts for the treatment of autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. +transcription factor target 31439976 hsa-mir-497 Multiple Sclerosis 5p can be considered critical targets for further studies on future therapeutic attempts for the treatment of autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. +other 31439649 hsa-mir-29b Fibrosis We hypothesized that collagen removal can be facilitated by microRNA-29b (miR-29b), a highly conserved, small, non-coding RNA, as a reduction in this microRNA has been reported during the development of fibrosis in the mammalian heart. +lncRNA target 31438982 hsa-mir-194 Glioma CONCLUSIONS: Reprogramming COX-2, mPGES-1 and CYP4A mediated-AA metabolism in glioma by flavonoid ISL inhibits the angiogenic Akt- FGF-2/TGF-beta/VEGF signaling through ceRNA effect of miR +lncRNA target 31438886 hsa-mir-6778 Colorectal Neoplasms Luciferase reporter analyses showed that YWHAE was a target of miR +transcription factor target 31438862 hsa-mir-32 Cardiomyopathies 5p could serve as prognostic diagnostic target for cardiac fibrosis. +genetics_GWAS 31438837 hsa-mir-34a Multiple Sclerosis Furthermore, miR-34a was significantly downregulated (Fold change = 0.41, P = 0.001) in the PBMCs from RRMS subjects. CONCLUSION: Although the genetic polymorphism of BIRC5 gene was associated with the disease risk, miR-34a was suggested to be involved in the regulation of survivin in the RRMS patients. +circulation_biomarker_diagnosis_up 31437718 hsa-mir-146a Alzheimer Disease In this study, blood levels of the candidate microRNAs (small noncoding RNAs that play a pivotal role in gene expression) miR-146a, miR-181a, miR-181b, miR +circulation_biomarker_diagnosis_up 31437718 hsa-mir-181a Alzheimer Disease In this study, blood levels of the candidate microRNAs (small noncoding RNAs that play a pivotal role in gene expression) miR-146a, miR-181a, miR-181b, miR +lncRNA target 31437523 hsa-mir-10a Enterocolitis, Necrotizing We determined the expression patterns of gga-miR-10a in the intestinal mucosal layer of chickens upon NE induction, and identified the target genes (MyD88, and SKP1) related to the host immune response to pathogens. +other 31436530 hsa-mir-122 Lupus Erythematosus, Systemic We found that two motifs embedded in miR-122 are responsible for high-affinity binding to Lupus La and sorting into vesicles formed in a cell-free reaction. +lncRNA target 31436390 hsa-mir-647 Uterine Cervical Neoplasms 5p targets AGR2, inhibiting cervical cancer cell proliferation and promoting apoptosis. +lncRNA target 31436388 hsa-mir-635 Carcinoma, Non-Small-Cell Lung Our results also identified miR-635 as a novel target of PART1, whose expression was inhibited by PART1 in NSCLC cell lines. In conclusion, our findings clarified the biologic significance of PART1/miR-635/JAK-STAT axis in NSCLC progression and provided novel evidence that PART1 may be a new potential therapeutic target for the treatment of NSCLC. +genetics_overexpression_promote 31436384 hsa-mir-379 Laryngeal Neoplasms Furthermore, restored TCF-4 expression rescued the inhibitory roles of miR-379 overexpression on cell proliferation, migration, and invasion.Our study for the first time demonstrated that miR-379/TCF-4 might involve in the progression of laryngeal carcinoma, and miR-379 appears to serve as a novel tumor suppressor in laryngeal carcinoma. +transcription factor target 31436339 hsa-mir-129 Intervertebral Disc Degeneration 5p might contribute to the development of IDD by targeting BMP2 expression. +lncRNA target 31435813 hsa-mir-940 Osteoarthritis Accordingly, the current study was intended to explore more about the potential role of miR-940 in the regulation of immune response, pertaining to osteoarthritis. In conclusion, the pathogenesis of OA can be regulated by miR-940/MyD88 axis, which can be achieved through the combined signaling mechanism of MyD88/NF-kappaB signaling, induced with the help of IL-1beta. +genetics_overexpression_suppress 31435644 hsa-mir-1290 Stomach Neoplasms NKD1 overexpression attenuated the stimulatory effects of miR-1290 on GC cells. +lncRNA target 31435512 hsa-mir-143 Cystic Fibrosis Luciferase assays were performed to elucidate direct miRNA::target interactions and showed that miR +transcription factor target 31435003 hsa-mir-146a Asthma Modulation of ILC2 function by miR-146a may depend on IL-33/interleukin 1 receptor-like 1 (IL1RL1 or ST2) signaling through inhibiting IRAK1 and TRAF6.miR-146a can inhibit IRAK1 and TRAF6, downstream molecules of ST2 signal pathway, thereby negatively regulate IL-33/ST2-activated ILC2 to inhibit asthma. +transcription factor target 31435003 hsa-mir-146 Asthma Modulation of ILC2 function by miR-146a may depend on IL-33/interleukin 1 receptor-like 1 (IL1RL1 or ST2) signaling through inhibiting IRAK1 and TRAF6.miR-146a can inhibit IRAK1 and TRAF6, downstream molecules of ST2 signal pathway, thereby negatively regulate IL-33/ST2-activated ILC2 to inhibit asthma. +lncRNA target 31434993 hsa-mir-146a Ischemic Stroke Taken together, the present study demonstrated that STV-Na exerted neuroprotective effects by modulating microglia/macrophage polarization in ischemic stroke via the GAS5/miR-146a-5p sponge. +lncRNA target 31434797 hsa-mir-625 Carcinoma, Renal Cell Hence, the LINC00511/miR-625/CCND1 pathway might be a promising therapeutic target in ccRCC. +circulation_biomarker_diagnosis_up 31434614 hsa-mir-454 Uterine Cervical Neoplasms 3p was downregulated in serum and tissue of cervical cancer subjects. +circulation_biomarker_diagnosis_up 31434614 hsa-mir-409 Uterine Cervical Neoplasms 3p was downregulated in serum and tissue of cervical cancer subjects. +genetics_overexpression_promote 31434611 hsa-mir-579 Tuberculosis Conversely, forced overexpression of cPWWP2A, by a recombinant adeno-associated virus construct, reversed MTB-induced miR-579 upregulation and macrophage cytotoxicity. +genetics_overexpression_promote 31434447 hsa-mir-98 Colonic Neoplasms Overexpression of let-7a or miR-98 partially reversed the biological effects of Postn overexpression in colon cancer cells, which implicated that Postn was a target gene of let-7a/miR-98. +genetics_overexpression_promote 31434447 hsa-let-7a Colonic Neoplasms Overexpression of let-7a or miR-98 partially reversed the biological effects of Postn overexpression in colon cancer cells, which implicated that Postn was a target gene of let-7a/miR-98. +transcription factor target 31434432 hsa-mir-21 Ichthyosis, Lamellar In addition, compared with rats in control group, mRNA levels of miRNA-21, MMP-9, PI3K, AKT, and protein levels of ERK, p-ERK, MMP-9 were significantly increased in CIH group(all P<0.05), whereas protein levels of Spry1, PI3K, p-AKT were significantly decreased (all P<0.05). Conclusions: CIH induces significant atrial remodeling in this rat model, which can be attenuated by tolvaptan possibly through modulating miRNA-21/Spry1/ERK/MMP-9 and miRNA-21/PTEN/PI3K/AKT signaling pathways. +genetics_overexpression_promote 31434359 hsa-mir-224 Colorectal Neoplasms A screening of prognosis-mediated miRNAs underlined that the overexpression of miR-224 promotes CRC metastasis, and is associated with high stage and poor survival. +circulation_biomarker_diagnosis_ns 31434314 hsa-mir-29b Chagas Cardiomyopathy Here, six circulating microRNAs (miR-19a-3p, miR +circulation_biomarker_diagnosis_ns 31434314 hsa-mir-208a Chagas Cardiomyopathy Here, six circulating microRNAs (miR-19a-3p, miR5p, miR-29b-3p, miR-30a-5p, miR-199b-5p and miR-208a-3p) were evaluated and compared among patients with CCC (n = 28), CD indeterminate form (n = 10) and healthy controls (n = 10). +circulation_biomarker_diagnosis_ns 31434314 hsa-mir-19a Chagas Cardiomyopathy Here, six circulating microRNAs (miR-19a-3p, miR +circulation_biomarker_diagnosis_ns 31434314 hsa-mir-199b Chagas Cardiomyopathy Here, six circulating microRNAs (miR-19a-3p, miR5p, miR-29b-3p, miR-30a-5p, miR-199b-5p and miR-208a-3p) were evaluated and compared among patients with CCC (n = 28), CD indeterminate form (n = 10) and healthy controls (n = 10). +circulation_biomarker_diagnosis_ns 31434314 hsa-mir-21 Chagas Cardiomyopathy Here, six circulating microRNAs (miR-19a-3p, miR +genetics_GWAS 31434288 hsa-mir-9-2 Mental Disorders This study aims to explore the role of genetic polymorphisms in the MIR9-2 (rs4916723) and MIR34B/C (rs4938723) genes on the susceptibility of psychiatric disorders in children from the 2004 Pelotas Birth Cohort. +lncRNA target 31433983 hsa-mir-124 Glioblastoma Constitutive ERK1/2 activation globally regulates miRNA expression in murine and human GBMs, while neuronal differentiation of GBM tumorspheres following the inhibition of ERK1/2 activation requires the functional expression of miR-124 and the depletion of its target gene SOX9. +lncRNA target 31433907 hsa-mir-296 Neuroblastoma 5p suppresses apoptosis of NB cells in vitro and in vivo. +lncRNA target 31433582 hsa-mir-186 Carcinoma, Hepatocellular CONCLUSION: LINC00665 was involved in cell viability, apoptosis, and autophagy in HCC via miR +other 31433581 hsa-mir-1301 Osteosarcoma CONCLUSION: miR-1301 was implicated in the chemosensitivity of osteosarcoma to epirubicin by modulating TRIAP1. +genetics_overexpression_promote 31433213 hsa-mir-335 Stomach Neoplasms Importantly, it was found that overexpressed miR +lncRNA target 31433203 hsa-mir-29 Diabetic Nephropathies These findings suggest that miR-192 and miRs-29a/b/c can be potential targets for DN remediation. +lncRNA target 31433203 hsa-mir-29a Diabetic Nephropathies These findings suggest that miR-192 and miRs-29a/b/c can be potential targets for DN remediation. +lncRNA target 31433128 hsa-mir-449b Nasopharyngeal Carcinoma The novel miR-449b-3p/ADAM17/NF-kappaB feedback loop could be a target for the clinical treatment of NPC. +other 31432701 hsa-mir-9 Inflammation Meanwhile, miR-9 down-regulation invalidated the effect of silencing cANRIL on inflammation and NF-kappaB and JNK/p38 pathways. +other 31432699 hsa-mir-122 Carcinoma, Transitional Cell Herein, we further tested the influence of long non-coding RNA urothelial carcinoma associated 1 (UCA1) on cardiomyocytes injury in AMI, along with the role of microRNA-122 (miR-122) in this influence. +other 31432699 hsa-mir-122 Myocardial Infarction Herein, we further tested the influence of long non-coding RNA urothelial carcinoma associated 1 (UCA1) on cardiomyocytes injury in AMI, along with the role of microRNA-122 (miR-122) in this influence. +transcription factor target 31432697 hsa-mir-99a Stomach Neoplasms In conclusion, this study demonstrated that Salidroside possessed anti-GC effects through regulating miR-99a/IGF1R axis and inhibiting MAPK/ERK and PI3K/AKT pathways. +circulation_biomarker_diagnosis_up 31432395 hsa-mir-1 limb ischemia microRNA-1 (miR-1) is upregulated in plasma from idiopathic PAH patients and in lungs from an experimental model of PAH. In conclusion, these data indicate that miR-1 induces endothelial dysfunction, suggesting a pathophysiological role in PAH. +lncRNA target 31432186 hsa-mir-378a Glioblastoma The present study indicated that miR378a3p suppresses the progression of GBM by reducing TSPAN17 expression, and may thus serve as a potential therapeutic target for treating patients with GBM. +lncRNA target 31432186 hsa-mir-378 Glioblastoma The present study indicated that miR378a3p suppresses the progression of GBM by reducing TSPAN17 expression, and may thus serve as a potential therapeutic target for treating patients with GBM. +lncRNA target 31432179 hsa-mir-451 Reperfusion Injury, Cerebral Ischemia The present study suggested that miRNA451 regulated cerebral ischemiareperfusioninduced inflammation, which is mediated through the TLR4/MyD88/NFkappaB signaling pathway. +lncRNA target 31432170 hsa-mir-671 Carcinoma, Non-Small-Cell Lung Treatment with miR6713p inhibitors suppressed cell proliferation, migration and invasion, and increased apoptosis in vitro, suggesting that miR6713p functions as an oncogene in NSCLC. +circulation_biomarker_diagnosis_down 31432169 hsa-mir-124 Myocardial Infarction, Acute It was revealed that the expression of miR1243p was significantly increased in the blood of patients with AMI and hypoxiatreated H9c2 cells. +lncRNA target 31432162 hsa-mir-93 Adenocarcinoma of Lung In vivo analysis further supported that cisplatin inhibited lung adenocarcinoma cell growth by regulating cyclin D2 and miR93 expression. In conclusion, our findings demonstrated that cisplatin could effectively inhibit lung adenocarcinoma cell proliferation by decreasing cyclin D2 expression via miR93. +genetics_GWAS 31432155 hsa-mir-381 Colorectal Neoplasms The present study emphasizes the general overlap of miRNA profiles in MSI tumor cells and their EVs, but also highlights the impact of a single tumor driver mutation on the expression of individual miRNAs, as exemplified by the downregulation of miR3813p in TGFBR2deficient MSI tumor cells and their secreted EVs. +transcription factor target 31432141 hsa-mir-20a Pre-Eclampsia The present study suggested that miR320a upregulation was involved in the development of PE by inhibiting the proliferation and invasion of trophoblast cells by targeting IL4, indicating that the miR320a/IL4 pathway may represent a novel therapeutic target for PE treatment. +lncRNA target 31432140 hsa-mir-130a ankylosing spondylitis 1 Collectively, our data indicated that miR130a3p was decreased in T cells from AS patients and it could regulate Tcell survival by targeting HOXB1. +lncRNA target 31432138 hsa-mir-607 Uterine Cervical Neoplasms In conclusion, the findings suggested that upregulation of TP73AS1 promoted cervical cancer progression by promoting CCND2 via the suppression of miR607 expression. +circulation_biomarker_diagnosis_up 31432137 hsa-mir-217 Atherosclerosis The level of miR217 was detected in the blood of patients with atherosclerosis using reverse transcriptionquantitative PCR. +genetics_overexpression_promote 31432120 hsa-mir-30 Retinoblastoma Overexpression of miR330 in RB cells significantly reduced the viability and invasion of cells in vitro. +genetics_knock down_promote 31432113 hsa-mir-208a Carcinoma, Non-Small-Cell Lung Furthermore, SRCIN1 knockdown was able to rescue the miR208amediated effects on NSCLC cells. +lncRNA target 31432107 hsa-mir-892a Lupus Erythematosus, Systemic Additionally, the level of a microRNA (miRNA) target of hsa_circ_0044235, hsamiRNA892a, was identified to be significantly increased in the PBMCs from patients with SLE. +other 31432092 hsa-mir-222 Intervertebral Disc Degeneration It has been demonstrated that miR222 is upregulated in human intervertebral disc (IVD) degeneration tissues; however, the underlying mechanisms remain unclear. +lncRNA target 31432092 hsa-mir-222 Substance Abuse, Intravenous Thus, on the whole, the findings of this study demonstrate that miR222 functions as a promoter of IVD development, partly via the regulation of TIMP3. +lncRNA target 31431734 hsa-mir-181c Inflammation, Post Stroke Based on informatics analysis we predicted that HMGB1 was a direct downstream target of miR-181c-5p, whereas Malat1 acted as a competitive endogenous RNA (ceRNA) for miR-181c-5p targeted the 3'-UTR of HMGB1 to promote inflammation after ischemic stroke. Taken together, our results demonstrate for the first time that Malat1/miR-181c-5p/HMGB1 axis may be a key pathway of BBR-induced antiinflammation effects in stroke, and they may provide a novel avenue for targeted therapy. +transcription factor target 31431691 hsa-mir-142 Lupus Erythematosus, Systemic BCL-6 suppresses the expression of miR +other 31431687 hsa-mir-106a esophagus adenocarcinoma This comprehensive data demonstrated the importance of miR92 cluster and miR-106a for progression as well as LNM in OAC indicating that those might be feasible prognostic biomarkers. +other 31431687 hsa-mir-17 esophagus adenocarcinoma This comprehensive data demonstrated the importance of miR92 cluster and miR-106a for progression as well as LNM in OAC indicating that those might be feasible prognostic biomarkers. +genetics_overexpression_promote 31431514 hsa-mir-124 Depression MiR-124 overexpression exacerbated depression-like behaviors and decreased SIRT1. +lncRNA target 31431501 hsa-mir-145 Peritoneal Fibrosis In conclusion, miR-145 promotes the EMT during the development of peritoneal fibrosis by suppressing FGF10 activity, suggesting that miR-145 represents a potential therapeutic target for managing peritoneal fibrosis. +circulation_biomarker_prognosis_ns 31431298 hsa-mir-206 Leukemia, Myeloid, Acute The results demonstrated that miR-206 expression levels in the bone marrow and serum of pediatric AML patients were remarkably decreased than those in normal controls, and low serum miR-206 expression was closely associated with the unfavorable clinicopathological characteristics and prognosis of pediatric AML patients. +other 31430983 hsa-mir-21 Myocardial Infarction Administration of CM reduced the infarcted size and immune cell infiltration in myocardium of rats with AMI, while depletion of miR-21 reduced the effect of CM. The expression of miR-21 is important for the protective effect of conditioned medium against myocardial infarction. +genetics_overexpression_promote 31430859 hsa-mir-655 Breast Neoplasms We established that overexpression of miR526b/miR655 promotes aggressive breast cancer phenotypes. +genetics_overexpression_promote 31430859 hsa-mir-526b Breast Neoplasms We established that overexpression of miR526b/miR655 promotes aggressive breast cancer phenotypes. +other 31430761 hsa-mir-34c Polycythemia Vera RESULTS: lnc-NONH promotes the expression of PFV Tas and miR-34c-5p. The interaction between lnc-NONH and miR-34c-5p enhances the transcriptional activity of the PFV IP. +lncRNA target 31430759 hsa-mir-145 Lupus Nephritis AIMS: The current study was conducted with the central objective of investigating the expression of microRNA-145 (miR-145) in renal vascular lesions (RVLs) in juvenile lupus nephritis (JLN) and its possible mechanism. miR-145 may be involved in the pathogenesis of RVLs and may be a new target for treatment of RVLs in lupus nephritis. +genetics_overexpression_promote 31430717 hsa-mir-24 Fibrosis, Renal In conclusion, our data indicate that overexpression of lncRNA NR_038323 may suppress HG-induced renal fibrosis via the miR +genetics_overexpression_promote 31430717 hsa-mir-24 Diabetic Nephropathies In conclusion, our data indicate that overexpression of lncRNA NR_038323 may suppress HG-induced renal fibrosis via the miR +genetics_GWAS 31430546 hsa-mir-4697 Parkinson Disease Recently, 5 previously Parkinson's disease (PD)-related loci: ACMSD/TMEM163, STK39, MIR4697, SREBF1/RAI1PD and MAPT, have been associated to PD in a Southern Spanish population. +lncRNA target 31430465 hsa-let-7b Retinal Diseases OIR-induced down-regulation of Igf1r was mediated at least partly by miR-let-7b as i) let-7b expression was augmented throughout and beyond the period of oxygen exposure, ii) let-7b directly targeted Igf1r mRNA, and iii) p53 knock-down blunted let-7b expression, restored Igf1r expression, and elicited choroidal revascularization. Altogether, this study uncovers a significant mechanism for defective choroidal revascularization in OIR, revealing a new role for p53/let-7b/IGF-1R axis in the retina. +genetics_overexpression_promote 31430452 hsa-mir-152 Keloid 3p mimic on these functions were notably partly reversed by FOXF1 overexpression. +lncRNA target 31429853 hsa-mir-21 Leukemia In this study, we examine the ability of leukemia microvesicles to induce proliferation in hematopoietic stem progenitor cells (HSPCs) via microRNA-21 dysregulation. +genetics_overexpression_promote 31429770 hsa-mir-200c Glioma In addition, MeCP2 in glioma tissues was negatively correlated with miR-200c expression, and miR-200c overexpression partially abrogated mesenchymal phenotype induced by MeCP2. More importantly, we showed that MeCP2 recruited H3K9 to the promoter of miR-200c by interacting with SUV39H1, resulting in EMT of glioma cells. +lncRNA target 31429725 hsa-mir-182 Colorectal Neoplasms CONCLUSIONS: Altogether, these data indicate that increased miR-182 expression may promote cell proliferation, suppress the apoptotic pathway and ultimately confer aggressive traits on CRC cells. +genetics_knock down_suppress 31429522 hsa-mir-1249 Carcinoma, Hepatocellular Knockdown miR +genetics_overexpression_promote 31428943 hsa-mir-543 Nasopharyngeal Carcinoma Overexpression of JAM-A attenuated miR +circulation_biomarker_diagnosis_ns 31428639 hsa-mir-146a Lupus Erythematosus, Systemic Moreover, the expression of miR-146a declined significantly in serum exosomes of SLE patients compared with healthy controls. +other 31428222 hsa-mir-219a Liver Diseases, Alcoholic Overall, these findings show that PCA-stimulated miR-219a-5p expression mitigates ALD by reducing p66shc-mediated ROS formation. +circulation_biomarker_diagnosis_ns 31428171 hsa-mir-146a Diabetes Mellitus On a molecular level, three circulating miRNAs, miR-155, miR-146a, and miR-15a, were identified in diabetic and nondiabetic skin wounds by PCR analysis. +circulation_biomarker_diagnosis_ns 31428171 hsa-mir-15 Diabetes Mellitus On a molecular level, three circulating miRNAs, miR-155, miR-146a, and miR-15a, were identified in diabetic and nondiabetic skin wounds by PCR analysis. +circulation_biomarker_diagnosis_ns 31428171 hsa-mir-15a Diabetes Mellitus On a molecular level, three circulating miRNAs, miR-155, miR-146a, and miR-15a, were identified in diabetic and nondiabetic skin wounds by PCR analysis. +circulation_biomarker_diagnosis_ns 31428171 hsa-mir-155 Diabetes Mellitus On a molecular level, three circulating miRNAs, miR-155, miR-146a, and miR-15a, were identified in diabetic and nondiabetic skin wounds by PCR analysis. +other 31428151 hsa-mir-144 Carcinoma, Pancreatic Ductal COL1A1. +other 31428151 hsa-mir-577 Carcinoma, Pancreatic Ductal COL1A1. +other 31427899 hsa-mir-21 Uterine Cervical Neoplasms CONCLUSIONS: Our findings suggest a physical interaction and functional cooperation between AP-1 transcription factor in the miR-21 promoter and may explain the effect of AP-1 on miR-21 gene expression in cervical cancer cells. +lncRNA target 31427735 hsa-mir-340 Glioblastoma 5p in GBM did not induce the differentiation of TAMs into polarized M2 cells but was able to promote the M2 polarization of TAMs through directly targeting LTBP-1. +other 31427592 hsa-mir-548k Head and Neck Neoplasms In the later stages of progression, HNSCC with and without nodal metastases showed some clear differences including high copy number gains of CCND1, hsa-miR-548k and TP63 in the metastases group. +genetics_knock down_promote 31427569 hsa-mir-485 Glioblastoma Knockdown of UPF1 or Linc-00313 significantly inhibited malignant biological behaviors of glioma cells by regulating miR +genetics_knock down_promote 31427569 hsa-mir-342 Glioblastoma Knockdown of UPF1 or Linc-00313 significantly inhibited malignant biological behaviors of glioma cells by regulating miR +circulation_biomarker_diagnosis_up 31427483 hsa-mir-122 Hepatitis, Chronic However, the researches on the accuracy of miR122 detection in chronic viral hepatitis have been inconsistent, leading us to conduct this meta-analysis to systematically summarize the diagnostic value of circulating miR-122 in patients with hepatitis B virus (HBV) and/or hepatitis C virus (HCV)-associated chronic viral hepatitis.Methods: A comprehensive literature search (updated to January 30, 2019) in PubMed, Cochrane library, EMBASE, CNKI, Wanfang, and CQVIP databases was performed to identify eligible studies. In addition, we found that serum might be a more promising matrix for detecting the expression of miR-122 than plasma.Conclusions: Our results demonstrated that circulating miR-122 have a relatively high diagnostic value for chronic viral hepatitis detection, especially in the patients with HCV-associated chronic viral hepatitis. +circulation_biomarker_diagnosis_up 31427483 hsa-mir-122 Hepatitis C However, the researches on the accuracy of miR122 detection in chronic viral hepatitis have been inconsistent, leading us to conduct this meta-analysis to systematically summarize the diagnostic value of circulating miR-122 in patients with hepatitis B virus (HBV) and/or hepatitis C virus (HCV)-associated chronic viral hepatitis.Methods: A comprehensive literature search (updated to January 30, 2019) in PubMed, Cochrane library, EMBASE, CNKI, Wanfang, and CQVIP databases was performed to identify eligible studies. In addition, we found that serum might be a more promising matrix for detecting the expression of miR-122 than plasma.Conclusions: Our results demonstrated that circulating miR-122 have a relatively high diagnostic value for chronic viral hepatitis detection, especially in the patients with HCV-associated chronic viral hepatitis. +circulation_biomarker_diagnosis_up 31427483 hsa-mir-122 Hepatitis B However, the researches on the accuracy of miR122 detection in chronic viral hepatitis have been inconsistent, leading us to conduct this meta-analysis to systematically summarize the diagnostic value of circulating miR-122 in patients with hepatitis B virus (HBV) and/or hepatitis C virus (HCV)-associated chronic viral hepatitis.Methods: A comprehensive literature search (updated to January 30, 2019) in PubMed, Cochrane library, EMBASE, CNKI, Wanfang, and CQVIP databases was performed to identify eligible studies. In addition, we found that serum might be a more promising matrix for detecting the expression of miR-122 than plasma.Conclusions: Our results demonstrated that circulating miR-122 have a relatively high diagnostic value for chronic viral hepatitis detection, especially in the patients with HCV-associated chronic viral hepatitis. +genetics_overexpression_promote 31427481 hsa-mir-384 Pneumonia, Mycoplasma We found that miR-384 was unregulated in PE, and overexpression of miR-384 could inhibit cell proliferation and invasion. Together, these results suggest that down-regulation of circPAPPA facilitates the onset and development of PE by suppressing trophoblast cells, with involvement of the miR-384/STAT3 signaling pathway. +circRNA target 31427478 hsa-mir-195 Squamous Cell Carcinoma of Head and Neck Mechanistically, circMYLK can serve as a competing endogenous RNA for miR-195 to increase cyclin D1 expression in LSCC, and rescue experiments further showed that restoration of miR-195 could block the oncogenic role of circMYLK in LSCC. In conclusion, our findings indicate that the circMYLK/miR-195/cyclin D1 regulatory axis could affect the proliferation and cell cycle progression of LSCC cells, and may provide a novel therapeutic target for the treatment of LSCC. +other 31427401 hsa-mir-181a Brain Ischemia We have previously demonstrated that preinjury treatment with anti-microRNA (miR)-181a preserved neurons and prevented astrocyte dysfunction in the hippocampal cornu ammonis-1 (CA1) following transient forebrain ischemia. In the present study, we assessed postinjury treatment with anti-miR-181a on recovery of CA1 neurons following transient forebrain ischemia in rats. +genetics_knock down_promote 31427084 hsa-mir-16 Osteosarcoma Meanwhile, overexpression of ATG4B significantly promoted the development of osteosarcoma cells attenuated by SNHG16 knockdown or miR-16 mimics. CONCLUSIONS: Overall, our findings showed the importance of the regulatory axis of SNHG16/miR-16/ATG4B underlying osteosarcoma progression and chemoresistance to cisplatin. +transcription factor target 31426855 hsa-mir-375 Uterine Cervical Neoplasms Furthermore, SEPT9 mediated miR-375 via the tumor-associated macrophages (TAMs) polarization, affecting the resistance to radiotherapy in cervical cancer. It promotes tumorigenesis and radioresistance of cervical cancer by targeting HMGB1-RB axis and causes polarization of macrophages by mediating miR-375. +transcription factor target 31426807 hsa-mir-139 Colorectal Neoplasms Additionally, miR-139 has been reported to be negatively correlated with chemoresistance, metastasis, and epithelial-mesenchymal transition (EMT) of CRC. Hence, we develop a nanoparticle formulation consisting of a polymer core to carry afatinib or miR-139, which is surrounded by lipids modified with a targeting ligand and a pH-sensitive penetrating peptide to improve the anticancer effect of cargos against CRC cells. +other 31426719 hsa-mir-200b Colorectal Neoplasms Conclusion: Microfibrial-associated glycoprotein 2, negatively modulated by miR-200b-3p, is an oncogene of colorectal cancer associated with patients' prognosis. +lncRNA target 31426282 hsa-mir-134 Carcinoma, Hepatocellular Taken together, our findings provide insight that Pyrogallol exerts antitumor effects in HCCs via miR-134 activation-mediated S-phase arrest and inhibition of PI3K/AKT/Skp2/cMyc signaling as a potent anticancer candidate. +genetics_GWAS 31425738 hsa-mir-29b Leukemia, Lymphocytic, Chronic, B-Cell Thus miR-34a and miR-29b may represent useful indicators for the prognosis of both Uygur and Han CLL patients. +genetics_GWAS 31425738 hsa-mir-34a Leukemia, Lymphocytic, Chronic, B-Cell Thus miR-34a and miR-29b may represent useful indicators for the prognosis of both Uygur and Han CLL patients. +genetics_overexpression_suppress 31425497 hsa-mir-449b Osteosarcoma C-Met is the downstream target of microRNA-449b-5p, and its level was inhibited in OS cells overexpressing microRNA-449b-5p. +lncRNA target 31425342 hsa-mir-143 Subarachnoid Hemorrhage Applying an anti-miRNA targeting approach in SAH does not seem to be a feasible approach because miRNA-143 and miRNA-145 are not upregulated following SAH. +lncRNA target 31425342 hsa-mir-145 Subarachnoid Hemorrhage Applying an anti-miRNA targeting approach in SAH does not seem to be a feasible approach because miRNA-143 and miRNA-145 are not upregulated following SAH. +transcription factor target 31425004 hsa-mir-142 Endometriosis 3p/KLF9/VEGFA signalling pathway may be a potential target in endometriosis treatment. +lncRNA target 31425002 hsa-mir-146a Carcinoma, Non-Small-Cell Lung In this study, we performed RNA-Sequencing (RNA-Seq) analysis following transfection of synthetic miR-146a-5p in an NSCLC cell line, A549, and validated our data with Gene Ontology and qRT-PCR analysis of known miR-146a-5p target genes. +circulation_biomarker_prognosis_ns 31424691 hsa-mir-34a Carcinoma, Basal Cell RESULTS: Serum miR-34a levels were significantly lower in basal cell carcinoma patients than in healthy volunteers (p<0.001). +genetics_overexpression_promote 31424681 hsa-mir-203 Urinary Bladder Neoplasms METHODS: Human bladder cancer T24 cell line with miR-203 overexpression were constructed. +genetics_overexpression_promote 31424678 hsa-mir-490 Prostatic Neoplasms CONCLUSION: The low expression and overexpression of miR-490 in prostate cancer may inhibit the proliferation, migration and invasion of prostate cancer cells and promote apoptosis by inhibiting the phosphorylation of AKT signal pathway. +transcription factor target 31424671 hsa-mir-335 Colorectal Neoplasms 5p regulates cell proliferation, migration as well as invasion of CRC cells through down-regulating LDHB, and demonstrated that miR +circulation_biomarker_diagnosis_ns 31424670 hsa-mir-28 Colorectal Neoplasms CONCLUSION: Our results indicated that serum miR +circulation_biomarker_diagnosis_ns 31424670 hsa-mir-1301 Colorectal Neoplasms CONCLUSION: Our results indicated that serum miR +circulation_biomarker_diagnosis_ns 31424670 hsa-mir-335 Colorectal Neoplasms CONCLUSION: Our results indicated that serum miR +transcription factor target 31424663 hsa-mir-155 Breast Neoplasms The MAPK7 expression was also upregulated in all the breast cancer cells and suppression of miR-155 resulted in its downregulation. +genetics_overexpression_promote 31424660 hsa-mir-204 Breast Neoplasms Since, PTEN regulates the PI3K/AKT signalling pathway, the effect of miR-204 overexpression was also assessed on this pathway and showed that miR-204 overexpression inhibits the expression of p-AKT and p-PI3K significantly in MCF7 breast cancer cells. +genetics_overexpression_promote 31424647 hsa-mir-19a Carcinoma, Non-Small-Cell Lung Rescue experiments showed that PTEN overexpression could partially reverse the regulatory effects of microRNA-19a on promoting proliferative and migratory abilities of NSCLC cells. +genetics_overexpression_promote 31424644 hsa-mir-133 Lung Neoplasms Overexpression of miR-133 in A549 lung cancer cells caused significant (p<0.05) inhibition of their proliferation via activation of apoptotic cell death, suggestive of the tumor suppressive role of miR-133. +exosome 31424364 hsa-mir-423 Breast Neoplasms CONCLUSIONS: Exosomes from DDP-resistant TNBC cells (231/DDP) altered the sensitivity of other breast cancer cells to DDP in an exosomal miR5p dependent manner. +exosome 31424364 hsa-mir-423 Triple Negative Breast Neoplasms CONCLUSIONS: Exosomes from DDP-resistant TNBC cells (231/DDP) altered the sensitivity of other breast cancer cells to DDP in an exosomal miR5p dependent manner. +genetics_overexpression_promote 31424277 hsa-mir-589 Carcinoma, Endometrioid 5p overexpression significantly suppressed EC cell proliferation, migration and invasion. +lncRNA target 31424161 hsa-let-7 Glioma Through the competitive endogenous RNA (ceRNA) mechanism, circCPA4 sponges let-7 to regulate the expression of CPA4 and glioma progression. The circCPA4/let-7/CPA4 axis regulates glioma progression by ceRNA mechanism, and circCPA4 could be a novel prognostic biomarker and target for glioma treatment. +other 31423286 hsa-mir-944 Lung Neoplasms hsa-miR-183 and hsa-miR-135b were used to distinguish lung tumors from normal samples taken from tissues adjacent to the tumor site, and hsa-miR-944 and hsa-miR-205 to further classify the tumors into LUAD and LUSC major subtypes. +other 31423286 hsa-mir-135b Lung Neoplasms hsa-miR-183 and hsa-miR-135b were used to distinguish lung tumors from normal samples taken from tissues adjacent to the tumor site, and hsa-miR-944 and hsa-miR-205 to further classify the tumors into LUAD and LUSC major subtypes. +other 31423286 hsa-mir-205 Lung Neoplasms hsa-miR-183 and hsa-miR-135b were used to distinguish lung tumors from normal samples taken from tissues adjacent to the tumor site, and hsa-miR-944 and hsa-miR-205 to further classify the tumors into LUAD and LUSC major subtypes. +other 31423286 hsa-mir-183 Lung Neoplasms hsa-miR-183 and hsa-miR-135b were used to distinguish lung tumors from normal samples taken from tissues adjacent to the tumor site, and hsa-miR-944 and hsa-miR-205 to further classify the tumors into LUAD and LUSC major subtypes. +lncRNA target 31423280 hsa-mir-124 Carcinoma, Non-Small-Cell Lung Bioinformatics analysis and luciferase reporter gene assay data further confirmed that LIMD2 was a direct target gene of microRNA-124 (miR-124), a well-known tumor suppressor in NSCLC. +lncRNA target 31423279 hsa-mir-381 Prostatic Neoplasms The results of the present study suggested that miR-381 may act as a tumor suppressor in PCa by directly targeting the AR. +genetics_knock down_promote 31423276 hsa-mir-2053 Carcinoma, Hepatocellular Mechanistically, it was found that overexpression of miR-2053 resulted in the downregulation of the phosphoinositide 3-kinase (PI3K) and Wnt/beta-catenin signaling pathways, which are aberrantly expressed in HCC. +lncRNA target 31423265 hsa-mir-96 Colorectal Neoplasms The objectives of the present study were to identify the aberrant expression of microRNA (miRNA) in colorectal carcinoma (CRC) tissues from published miRNA profiling studies and to investigate the effects of the identified miRNA inhibitor and mimic miR +lncRNA target 31423264 hsa-mir-139 Glioblastoma Of the five target genes that were enriched in the glioblastoma pathway, in the WikiPathway database, both HRas proto-oncogene, GTPase and MET proto-oncogene, receptor tyrosine kinase target genes of hsa-miR +genetics_overexpression_promote 31423262 hsa-mir-181 Glioblastoma Overexpression of CCL8 inversely reversed the proliferation, invasion and migration-promoting effects of miR-181 in glioblastoma cells. +lncRNA target 31423254 hsa-mir-125b Melanoma miR-125b may be used for the early screening of melanoma and determining the prognosis of patients with melanoma, and may be a potential target for the treatment of the disease. +genetics_overexpression_promote 31423246 hsa-mir-758 Uterine Cervical Neoplasms Results of CCK-8, colony formation and Transwell assays revealed that miR-758 overexpression markedly decreased cell viability, proliferation, invasion and migration. +other 31423238 hsa-mir-153 Adenocarcinoma of Lung These results indicated that miR-206, miR-137, miR-153, hub genes and enriched TFs in the pink and red modules exert a potentially pivotal function in the development of LUAD. +other 31423238 hsa-mir-206 Adenocarcinoma of Lung These results indicated that miR-206, miR-137, miR-153, hub genes and enriched TFs in the pink and red modules exert a potentially pivotal function in the development of LUAD. +other 31423238 hsa-mir-137 Adenocarcinoma of Lung These results indicated that miR-206, miR-137, miR-153, hub genes and enriched TFs in the pink and red modules exert a potentially pivotal function in the development of LUAD. +other 31423228 hsa-mir-362 Stomach Neoplasms 5p upregulation combined with cisplatin treatment may serve as a promising therapeutic strategy for patients with cisplatin-resistant GC. +other 31423214 hsa-mir-125a Stomach Neoplasms Therefore, the results of the present study provide evidence that low expression of miR-125a-5p may be associated with a poor prognosis, suggesting its value as a tumor biomarker for patients with GC. +genetics_overexpression_promote 31423213 hsa-mir-432 Uterine Cervical Neoplasms In addition, restored FN1 expression neutralized the effects of miR-432 overexpression in cervical cancer cells. +other 31423195 hsa-mir-140 Stomach Neoplasms In conclusion, the results of the present study suggest that the SNHG20/miR5p/NDRG3 axis may be involved in mediating resistance to 5-FU in gastric cancer. +other 31423192 hsa-mir-100 Lung Neoplasms Therefore, miR-100 shows potential as a prognostic marker for NSCLC. +genetics_knock down_promote 31423164 hsa-mir-145 Prostatic Neoplasms Overexpression of miR-145 and lncRNA GAS5 promoted apoptosis and inhibited cell proliferation in prostate carcinoma cell lines, whereas lncRNA GAS5 knockdown had an opposite effect. +other 31423132 hsa-mir-143 Prostatic Neoplasms Since miRNA-based mechanisms are shown to be involved in the pathogenesis of prostate cancer (PCa), the aim of the present study was to evaluate the effect of rs4938723, rs1076064 and rs4705343 occurring in regulatory regions of miR-34b/c, miR-143/145 and miR-378, respectively, on PCa risk and progression in Serbian population. +other 31423132 hsa-mir-378 Prostatic Neoplasms Since miRNA-based mechanisms are shown to be involved in the pathogenesis of prostate cancer (PCa), the aim of the present study was to evaluate the effect of rs4938723, rs1076064 and rs4705343 occurring in regulatory regions of miR-34b/c, miR-143/145 and miR-378, respectively, on PCa risk and progression in Serbian population. +other 31423132 hsa-mir-34b Prostatic Neoplasms Since miRNA-based mechanisms are shown to be involved in the pathogenesis of prostate cancer (PCa), the aim of the present study was to evaluate the effect of rs4938723, rs1076064 and rs4705343 occurring in regulatory regions of miR-34b/c, miR-143/145 and miR-378, respectively, on PCa risk and progression in Serbian population. +genetics_knock down_promote 31423109 hsa-mir-125a Stomach Neoplasms Moreover, knockdown of DKK3 and overexpression of miR-125a markedly promoted the migratory and invasive abilities of GC cells. +genetics_overexpression_promote 31423013 hsa-mir-543 Esophageal Neoplasms pylori increased the expression of miR-543 in human gastric cancer tissue when compared with H. pylori-associated gastric cancer, CagA induces overexpression of miR-543, which subsequently targets SIRT1 to suppress autophagy. +transcription factor target 31423010 hsa-mir-17 Multiple Myeloma 5p inhibited retarded tumor growth in a MM xenograft model. +lncRNA target 31422941 hsa-mir-146b Osteoarthritis Our study indicates that miR-146b plays a critical role in the progression of injury-induced osteoarthritis by directly targeting A(2)M expression to elevate the proteolytic enzyme production and stimulate chondrocytes apoptosis, and miR-146b as well as A(2)M could be therapeutic targets. +other 31422516 hsa-mir-423 Diabetic Angiopathies miR-423 may be involved in the regulation of diabetic vascular retinal proliferation. +circulation_biomarker_diagnosis_ns 31422498 hsa-mir-222 Glioblastoma CONCLUSION: Detection of circulating miR-221 and miR-222 may be used as circulating molecular marker for diagnosis and prediction of outcome for patients with GBM. +transcription factor target 31422208 hsa-mir-204 Squamous Cell Carcinoma of Head and Neck Furthermore, miR-204 and miR-211 were significantly involved in the network with identical mature structures, indicating them as key miRNAs in HNSCC. CONCLUSION: This study reveals the comprehensive molecular regulatory networks centralized by miRNAs in HNSCC and uncovers the crucial role of miR-204 and miR-211, which may become potential diagnostic and therapeutic targets. +transcription factor target 31422208 hsa-mir-211 Squamous Cell Carcinoma of Head and Neck Furthermore, miR-204 and miR-211 were significantly involved in the network with identical mature structures, indicating them as key miRNAs in HNSCC. CONCLUSION: This study reveals the comprehensive molecular regulatory networks centralized by miRNAs in HNSCC and uncovers the crucial role of miR-204 and miR-211, which may become potential diagnostic and therapeutic targets. +other 31422202 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck MATERIALS AND METHODS: An OSCC-associated panel of 5 microRNAs (miR-24; miR-21; miR-99a; let-7c; miR-100;) was quantified by qPCR in 190 individuals with and without mucosal abnormalities, including OSCC (n=53) and OPMDs (n=74). +other 31422202 hsa-mir-24 Squamous Cell Carcinoma of Head and Neck MATERIALS AND METHODS: An OSCC-associated panel of 5 microRNAs (miR-24; miR-21; miR-99a; let-7c; miR-100;) was quantified by qPCR in 190 individuals with and without mucosal abnormalities, including OSCC (n=53) and OPMDs (n=74). +other 31422202 hsa-mir-99a Squamous Cell Carcinoma of Head and Neck MATERIALS AND METHODS: An OSCC-associated panel of 5 microRNAs (miR-24; miR-21; miR-99a; let-7c; miR-100;) was quantified by qPCR in 190 individuals with and without mucosal abnormalities, including OSCC (n=53) and OPMDs (n=74). +other 31422202 hsa-let-7c Squamous Cell Carcinoma of Head and Neck MATERIALS AND METHODS: An OSCC-associated panel of 5 microRNAs (miR-24; miR-21; miR-99a; let-7c; miR-100;) was quantified by qPCR in 190 individuals with and without mucosal abnormalities, including OSCC (n=53) and OPMDs (n=74). +lncRNA target 31422096 hsa-mir-374c Hypertension, Pulmonary Taken conjointly, silencing of lncRNA Tug1 down-regulated the Foxc1 expression by binding to miR-374c, thereby inhibiting the proliferation and migration, while promoting apoptosis of PASMCs to impede pulmonary vascular remodeling in HPH via the Notch signaling pathway. +lncRNA target 31422060 hsa-mir-615 Carcinoma, Non-Small-Cell Lung In conclusion, our study suggested that HOTTIP might promote glycolysis under hypoxic conditions at least partly through regulating miR +circulation_biomarker_diagnosis_ns 31421994 hsa-mir-28 Prostatic Neoplasms 3p, -148a, and -224) or high-grade prostate cancer (miR-28 and -100) in plasma at prostate biopsy was examined in pre- and post-RP plasma of prostate cancer patients using real-time PCR and compared using Wilcoxon signed-ranked test. +circulation_biomarker_diagnosis_ns 31421994 hsa-mir-100 Prostatic Neoplasms 3p, -148a, and -224) or high-grade prostate cancer (miR-28 and -100) in plasma at prostate biopsy was examined in pre- and post-RP plasma of prostate cancer patients using real-time PCR and compared using Wilcoxon signed-ranked test. +lncRNA target 31421833 hsa-mir-496 Carcinoma, Non-Small-Cell Lung For farther researching the regulation mechanism of miR-496 on NSCLC, we screen Brain derived neurotrophic factor (BDNF) as a potential target of miR-496 by bioinformatic methods and predicted a possible target of miR-496 in the 3'untranslated region (UTR) of miR-496. +genetics_knock down_suppress 31421682 hsa-mir-200b Polycystic Ovary Syndrome Granulosa-like tumor cell line (KGN) was cultured for cell counting kit-8 (CCK-8) assays after over-expression of miR-200b, miR-200c or knockdown phosphatase and tensin homolog (PTEN). +lncRNA target 31421682 hsa-mir-200c Polycystic Ovary Syndrome Several studies have reported that the aberrant expression of miRNAs contributes a lot to disordered folliculogenesis in PCOS, though the role and underlying mechanism of microRNA-200b (miR-200b) and microRNA-200c (miR-200c) in the development of PCOS remain unclear. CONCLUSION: Our findings demonstrate that miR-200b and miR-200c suppress the proliferation of KGN cells by targeting PTEN, and this might provide new evidence for abnormal proliferation of GCs in PCOS. +circulation_biomarker_diagnosis_up 31421628 hsa-mir-29b Multiple Sclerosis, Relapsing-Remitting miR-29b expression has been shown to be upregulated in memory CD4+T cells from relapsing-remitting MS (RR-MS) patients, which may reflect chronic Th1 inflammation. We analyzed the expression level of miR-29b variants and MxA using the peripheral blood of MS patients treated with IFN-beta for more than one year. +other 31421224 hsa-mir-6077 Adenocarcinoma of Lung Therefore, our results indicated that miR-6077 represses the expression of GLUT1 and enhances the sensitivity of patients-derived lung AC cells to anlotinib. +other 31421163 hsa-mir-29a Polycystic Ovary Syndrome These findings suggest that miR-29a is involved in GC proliferation and steroidogenesis, providing insights into PCOS pathogenesis. +lncRNA target 31421050 hsa-mir-1228 Liver Neoplasms MATERIAL AND METHODS Quantitative real-time polymerase chain reaction (RT-qPCR) was used to evaluate the expression level of circ_100395 and microRNAs-1228 (miR-1228) in liver cancer samples and the adjacent non-tumor tissues. Moreover, upregulation of circ_100395 in liver cancer cells inhibited cell proliferation, induced apoptosis, then silenced the EMT pathway and reduced migration and invasion abilities, while this anti-tumor effect was significantly reversed by the downstream target, miR-1228. +lncRNA target 31420931 hsa-mir-93 Uterine Cervical Neoplasms These key findings demonstrated that upregulation of ZNF667-AS1 could suppress the progression of CC via the modulation of miR +circulation_biomarker_diagnosis_ns 31420923 hsa-mir-107 Alzheimer Disease METHODS: Plasma samples from 120 AD patients, 120 Parkinson's disease (PD) patients (served as disease control), and 120 healthy controls were collected for miR-103 and miR-107 detections using real-time quantitative polymerase chain reaction. +circulation_biomarker_diagnosis_ns 31420923 hsa-mir-103 Alzheimer Disease METHODS: Plasma samples from 120 AD patients, 120 Parkinson's disease (PD) patients (served as disease control), and 120 healthy controls were collected for miR-103 and miR-107 detections using real-time quantitative polymerase chain reaction. +circulation_biomarker_diagnosis_up 31420913 hsa-mir-320d Colorectal Neoplasms CONCLUSION: Serum exosomal miR-320d is a promising non-invasive diagnostic biomarker for distinguishing metastatic from non-metastatic CRC. +lncRNA target 31420607 hsa-mir-29b Carcinoma Taken together, our findings reveal a novel miR-29b/RARbeta/ING4 pathway that regulates tumorigenic properties of Tsc2-deficient cells, and that may serve as a potential therapeutic target for TSC, lymphangioleiomyomatosis (LAM), and other mTORC1-hyperactive tumors. +lncRNA target 31419987 hsa-mir-504 Glioblastoma CONCLUSIONS: Our results suggest that miR-504 suppresses the aggressive biological processes associated with the ME phenotype of GBM and could be a potential candidate for therapeutic applications in these malignant brain tumors. +genetics_overexpression_promote 31419642 hsa-mir-34a Neuroblastoma For our proof of concept study we have selected as a model the miRNA-34a, which acts as a tumor suppressor in a number of cancers including neuroblastoma. In particular, miRNA-34a is a direct regulator of MYCN oncogene, whose overexpression is a prominent biomarker for the highly aggressive neuroblastoma phenotype. +lncRNA target 31419446 hsa-mir-1224 Osteosarcoma 5p/FADS1 axis might be a potential therapeutic target for OS. +genetics_overexpression_promote 31419344 hsa-mir-611 Squamous Cell Carcinoma of Head and Neck Finally, miR-611 induced a malignant phenotype of TSCC, which was rescued by overexpression of FOXN3. +genetics_overexpression_promote 31419217 hsa-mir-1297 Stomach Neoplasms Exogenic overexpression of miR-1297 in GC cell lines can inhibit cell proliferation and colony formation and induce apoptosis, and inhibition of miR-1297 in GC cell lines can promote cell proliferation and colony formation, and reduce apoptosis in vitro. +transcription factor target 31418900 hsa-mir-130b Uterine Cervical Neoplasms In this study, we observed that miR-130b was able to cause the accumulation of DNA double-strand breaks through suppressing the gene expression of C-terminal binding protein interacting protein and to accelerate cell apoptosis by preventing DNA damage repairs in cervical cancer cells. +other 31417866 hsa-mir-499a Squamous Cell Carcinoma of Head and Neck Hsa-miR-499a was associated with N stage in high-tobacco exposed HNSCC. +lncRNA target 31417861 hsa-mir-326 Breast Neoplasms Altogether, our results revealed that miR-326 play a tumor-suppressive role in breast cancer through inhibiting ErbB/PI3K pathway and miR-326 may serve as a potential therapeutic target for the treatment of patients with breast cancer. +circulation_biomarker_prognosis_up 31417645 hsa-mir-200 Colorectal Neoplasms Additionally, subgroup analysis of sample types revealed a significant association between higher expression of the miR-200 family in the plasma and poorer OS (HR=1.23, 95% CI 1.08-1.41) and RFS (HR=2.39, 95% CI 1.20-4.77), which indicates that the miR-200 family can be used as an easily detectable biomarker for evaluation of the prognosis of patients with colorectal cancer. +lncRNA target 31417307 hsa-mir-1 Carcinoma, Renal Cell 3p inhibited the invasion and migration property of RCC cells by directly targeting Fibronectin 1. +genetics_overexpression_promote 31417288 hsa-mir-382 Glioma In addition, overexpression of miR +other 31417287 hsa-mir-373 Neuroblastoma The newly identified miR-373/SRCIN1 axis represents a new potential candidate for therapeutic intervention of malignant NB. +genetics_knock down_promote 31417285 hsa-mir-3691 Carcinoma, Hepatocellular Furthermore, gain-or loss-of function assays demonstrated that miR +genetics_overexpression_promote 31417281 hsa-mir-1270 Glioblastoma WT1 overexpression in hsa-miR +genetics_knock down_promote 31417277 hsa-mir-22 Esophageal Squamous Cell Carcinoma Conclusion: Our results demonstrate that H19 knockdown downregulates the WNT1 via upregulating miR3p expression, which leads to the inhibition of cells proliferation, migration and stemness in the radioresistant ESCC cells. +other 31417117 hsa-mir-205 Glioblastoma Thus, we have used an amperometric dual magnetosensor capable of monitoring a miR-21/miR-205 signature to screen for new drugs that restore these miRs to non-tumorigenic levels in cell models of breast cancer and glioblastoma. +other 31417117 hsa-mir-21 Breast Neoplasms Thus, we have used an amperometric dual magnetosensor capable of monitoring a miR-21/miR-205 signature to screen for new drugs that restore these miRs to non-tumorigenic levels in cell models of breast cancer and glioblastoma. +other 31417117 hsa-mir-21 Glioblastoma Thus, we have used an amperometric dual magnetosensor capable of monitoring a miR-21/miR-205 signature to screen for new drugs that restore these miRs to non-tumorigenic levels in cell models of breast cancer and glioblastoma. +other 31417117 hsa-mir-205 Breast Neoplasms Thus, we have used an amperometric dual magnetosensor capable of monitoring a miR-21/miR-205 signature to screen for new drugs that restore these miRs to non-tumorigenic levels in cell models of breast cancer and glioblastoma. +lncRNA target 31416454 hsa-mir-1975 Influenza, Human Unexpectedly, hsa-miR-1975 mimics inhibited influenza virus replication while hsa-miR-1975 sponges enhanced the virus replication. +other 31416448 hsa-mir-21 Venous Thrombosis In addition, lower expression level of miR-21 in DVT patients was associated with an increase of recurrent DVT and post thrombotic syndrome (PTS). CONCLUSIONS: Our data revealed a role of miR-21 in regulating biological function of EPCs and could be a predictor for recurrent DVT or PTS. +lncRNA target 31416393 hsa-mir-33a Liver Neoplasms Our study provides evidence that downregulated CRNDE could upregulate miR-33a and inhibit HMGA2 expression, thus significantly promotes apoptosis of liver cancer cells and inhibiting its proliferation, migration, invasion and drug resistance. +circulation_biomarker_diagnosis_ns 31416388 hsa-mir-146a Atherosclerosis Our results showed that miRNA-146a was enriched in serum-derived exosomes of AS patients and oxLDL-treated macrophage THP +genetics_overexpression_promote 31415795 hsa-mir-223 Diabetic Retinopathy 3p was frequently overexpressed in DR samples and human retinal endothelial cells (hRECs) in hyperglycemia, but it was decreased in hyperglycemia after the addition of transthyretin (TTR). +lncRNA target 31415657 hsa-mir-27b Graves Ophthalmopathy CONCLUSIONS: Our results indicated that miR-27a and miR-27b inhibited adipogenesis in orbital fibroblasts from GO patients. +lncRNA target 31415657 hsa-mir-27a Graves Ophthalmopathy CONCLUSIONS: Our results indicated that miR-27a and miR-27b inhibited adipogenesis in orbital fibroblasts from GO patients. +genetics_GWAS 31415369 hsa-mir-145 Sepsis The T allele of the miR-21 SNP rs13137 and the T allele of the miR-145 SNP rs353291 (OR = 0.685, 95% CI = 0.566-0.820, P < .001) were found to be a protective factor for sepsis (OR = 0.755, 95% CI = 0.632-0.896, P < .001). +genetics_GWAS 31415369 hsa-mir-21 Sepsis The T allele of the miR-21 SNP rs13137 and the T allele of the miR-145 SNP rs353291 (OR = 0.685, 95% CI = 0.566-0.820, P < .001) were found to be a protective factor for sepsis (OR = 0.755, 95% CI = 0.632-0.896, P < .001). +other 31415363 hsa-mir-25 Multiple Myeloma The results of our meta-analysis revealed that upregulated miR-92a level and downregulated miR-16, miR-25, miR-744, miR-15a, let-7e, and miR-19b expression were associated with poor prognosis in MM. +other 31415363 hsa-mir-19b Multiple Myeloma The results of our meta-analysis revealed that upregulated miR-92a level and downregulated miR-16, miR-25, miR-744, miR-15a, let-7e, and miR-19b expression were associated with poor prognosis in MM. +other 31415363 hsa-mir-16 Multiple Myeloma The results of our meta-analysis revealed that upregulated miR-92a level and downregulated miR-16, miR-25, miR-744, miR-15a, let-7e, and miR-19b expression were associated with poor prognosis in MM. +other 31415363 hsa-mir-92a Multiple Myeloma The results of our meta-analysis revealed that upregulated miR-92a level and downregulated miR-16, miR-25, miR-744, miR-15a, let-7e, and miR-19b expression were associated with poor prognosis in MM. +other 31415363 hsa-mir-744 Multiple Myeloma The results of our meta-analysis revealed that upregulated miR-92a level and downregulated miR-16, miR-25, miR-744, miR-15a, let-7e, and miR-19b expression were associated with poor prognosis in MM. +other 31415216 hsa-let-7 Fetal Growth Retardation Here, we show that LIN28A and LIN28B are significantly lower and lethal-7 (let-7) microRNAs (miRNAs) significantly higher in term human IUGR vs. +other 31414764 hsa-mir-155 Diabetic Nephropathies Furthermore, we detected a significant negative correlation between cell-free miR-155 expression and GFR only in patients with microalbuminuria (r = -0.70, p = 0.001). CONCLUSIONS: It seems that miR-155 can discriminate diabetic and nondiabetic status, but is not an appropriate biomarker for tracking of macroalbuminuria. +circulation_biomarker_diagnosis_up 31414759 hsa-mir-29b Osteoarthritis BACKGROUND: The current study aims to verify the abnormal expression of miR-29b-3p in peripheral blood mono-nuclear cells and synovial fluid of patients with osteoarthritis (OA), and to explore whether this abnormality is related to the severity of OA. +circulation_biomarker_diagnosis_up 31414754 hsa-mir-494 Prostatic Neoplasms CONCLUSIONS: miR-494 was upregulated in the serum of the patients with prostate cancer and circulating miR-494 can be used as a biomarker for the early diagnosis of prostate cancer. +genetics_overexpression_promote 31414268 hsa-mir-16 Stomach Neoplasms This study demonstrated that HGF can be repressed by overexpressed miR-15a/16/195, which resulted in the suppression of GC cell proliferation and migration. +genetics_overexpression_promote 31414268 hsa-mir-15a Stomach Neoplasms This study demonstrated that HGF can be repressed by overexpressed miR-15a/16/195, which resulted in the suppression of GC cell proliferation and migration. +genetics_overexpression_promote 31414268 hsa-mir-195 Stomach Neoplasms This study demonstrated that HGF can be repressed by overexpressed miR-15a/16/195, which resulted in the suppression of GC cell proliferation and migration. +other 31413763 hsa-mir-92a Carcinoma The current meta-analysis assessed the prognostic value of miR-92a in various carcinomas. +other 31413665 hsa-mir-362 Carcinoma, Hepatocellular 3p/Rab23 axis, which provides a novel direction and theoretical basis for the early diagnosis and treatment of HCC. +circRNA target 31413634 hsa-mir-585 Colorectal Neoplasms We demonstrated that hsa_circRNA_102958 promoted CDC25B expression through inhibiting miR-585 in CRC. Conclusion: Taken together, our findings revealed the novel oncogenic roles of hsa_circRNA_102958 in CRC through miR-585/CDC25B axis. +other 31413629 hsa-mir-206 Triple Negative Breast Neoplasms We investigated the impact of microRNA-206 (miR-206) on transmembrane 4 L6 family member 1 (TM4SF1) in TNBC for therapeutic purpose. These findings indicate that miR-206 could be used as a potential therapeutic agent for TNBC. +genetics_overexpression_suppress 31413593 hsa-mir-27a Esophageal Squamous Cell Carcinoma Overexpression of miR-27a in ESCC cell lines caused a reduction of Hsp90 mRNA and protein. +lncRNA target 31413591 hsa-mir-132 Urinary Bladder Neoplasms Conclusion: In short, our results suggest that miR-132 may play a suppressive role in the metastasis of BC cells via TGFbeta1/Smad2 signaling pathway. +circulation_biomarker_diagnosis_ns 31413305 hsa-mir-181 Obesity We aimed to study the miR-181d expression in the blood and adipose tissue in a cohort of obese and non-obese people, assessing its possible role in obesity. +circulation_biomarker_diagnosis_ns 31413305 hsa-mir-181d Obesity We aimed to study the miR-181d expression in the blood and adipose tissue in a cohort of obese and non-obese people, assessing its possible role in obesity. +circulation_biomarker_diagnosis_up 31413214 hsa-mir-375 Rhinitis, Allergic After treatment, compared with the control group, the level of miR-375 in the serum was down-regulated (P<0.01), while the levels of target genes (PDK1, AKT1, JAK2 and STAT3) were up-regulated (all P<0.05), and the levels of TNF-alpha, IL-6, IL-10, and IL-13 were down-regulated in the AR group (all P<0.05). +lncRNA target 31413212 hsa-mir-21 Carcinoma, Pancreatic Ductal Results: MiRNA-21 was screened as a gene associated with pancreatic ductal carcinoma via hierarchy clustering analysis and gene function analysis. +genetics_overexpression_promote 31413208 hsa-mir-627 Osteosarcoma 3p promoted osteosarcoma cell proliferation and metastasis, while its overexpression had the opposite effect. +lncRNA target 31412983 hsa-mir-21 Status Asthmaticus CASC7 expression was suppressed while miR-21 expression and AKT activity were promoted in ASMCs from severe asthma patients. CONCLUSION: CASC7 increased corticosteroid sensitivity by inhibiting the PI3K/AKT signaling pathway via targeting miR-21, which provided a promising potential target for designing novel therapeutic strategy for severe asthma. +other 31412903 hsa-mir-513 Ovarian Neoplasms Moreover, FLVCR1-AS1 reversed the effect of miR-513 on the OSC cell growth, which might be associated with the role of YAP1. CONCLUSION: Taken together, FLVCR1-AS1 mediated miR-513/YAP1 signaling to promote cell progression, migration, invasion and EMT process in OSC cells. +other 31412786 hsa-mir-101a Microphthalmos RESULTS: Results revealed that miR-101a-3p and miR-144a-3p directly regulated the expression of microphthalmia-associated transcription factor, thereby affecting melanin synthesis. +other 31412786 hsa-mir-101 Microphthalmos RESULTS: Results revealed that miR-101a-3p and miR-144a-3p directly regulated the expression of microphthalmia-associated transcription factor, thereby affecting melanin synthesis. +other 31412786 hsa-mir-144a Microphthalmos RESULTS: Results revealed that miR-101a-3p and miR-144a-3p directly regulated the expression of microphthalmia-associated transcription factor, thereby affecting melanin synthesis. +transcription factor target 31412123 hsa-mir-431 Tuberculosis tuberculosis infection of macrophages and suppression of heat shock factor 1, a transcriptional regulator of MDR1 through the up-regulation of miR-431. +lncRNA target 31412103 hsa-mir-223 Encephalomyelitis, Autoimmune, Experimental 3p and miR-27a-3p are upregulated in response to inflammation to mediate a compensatory neuroprotective gene expression program that desensitizes neurons to glutamate by targeting messenger RNAs involved in glutamate receptor signalling. +lncRNA target 31412103 hsa-mir-27a Encephalomyelitis, Autoimmune, Experimental 3p and miR-27a-3p are upregulated in response to inflammation to mediate a compensatory neuroprotective gene expression program that desensitizes neurons to glutamate by targeting messenger RNAs involved in glutamate receptor signalling. +genetics_overexpression_suppress 31411930 hsa-mir-5195 Osteosarcoma 3p overexpression in OS cells. +lncRNA target 31411918 hsa-mir-124 Keloid Overall, our study implied that HOXA11-AS induces ColI synthesis to promoted keloid formation via sponging miR +lncRNA target 31411791 hsa-mir-1271 Ovarian Neoplasms Mammalian target of rapamycin (mTOR) siRNA (simTOR) co-transfection was performed to verify the role of mTOR in the suppression effect of miR-1271 on ovarian cancer. +lncRNA target 31411745 hsa-mir-182 Encephalomyelitis, Autoimmune, Experimental MicroRNA 182 is important for the clonal expansion of CD4(+) T cells (Th) following IL-2 stimulation and is a potential therapeutic target for autoimmune diseases. Together, our results provide evidence that microRNA 182 may be one of the transitional hubs contribution to regulate Th cells expansion in response to self-antigens and differentiation of antigen specific Th cells during the progression of autoimmune inflammations. +other 31411334 hsa-mir-28 Endometriosis Only the model for minimal-mild endometriosis (Model 2: hsa-miR-125b-5p, hsa-miR5p and hsa-miR-29a-3p) had diagnostic power above chance performance in the independent validation (AUC = 60%) with an acceptable sensitivity (78%) but poor specificity (37%). +other 31411334 hsa-mir-125b Endometriosis Only the model for minimal-mild endometriosis (Model 2: hsa-miR-125b-5p, hsa-miR5p and hsa-miR-29a-3p) had diagnostic power above chance performance in the independent validation (AUC = 60%) with an acceptable sensitivity (78%) but poor specificity (37%). +other 31411334 hsa-mir-29a Endometriosis Only the model for minimal-mild endometriosis (Model 2: hsa-miR-125b-5p, hsa-miR5p and hsa-miR-29a-3p) had diagnostic power above chance performance in the independent validation (AUC = 60%) with an acceptable sensitivity (78%) but poor specificity (37%). +other 31411213 hsa-mir-34a Carcinoma, Non-Small-Cell Lung Further studies in chick CAM xenograft models confirmed the anti-cancer activity of TF-TQ-Np by controlling the p53/miR-34a/miR-16 axis. +other 31411213 hsa-mir-16 Carcinoma, Non-Small-Cell Lung Further studies in chick CAM xenograft models confirmed the anti-cancer activity of TF-TQ-Np by controlling the p53/miR-34a/miR-16 axis. +transcription factor target 31411118 hsa-mir-151a Osteoporosis, Postmenopausal In conclusion, our findings suggested that miR-151a-3p contributed to the pathogenesis of postmenopausal osteoporosis, and promoted its progress by targeting SOCS5 and activating JAK2/STAT3 signaling. Thus, anti-miR-151a-3p could be a potential therapeutic strategy for postmenopausal osteoporosis. +lncRNA target 31411003 hsa-mir-93 Myelodysplastic Syndromes In addition, miR5p could bind to HIF-1alpha by targeting, showing its potential to be the target of HIF-1alpha in MDS. +other 31411001 hsa-mir-141 Arthritis, Rheumatoid In summary, the protective role of MEG3 in RA was proved to be exerted by the increase in the rate of proliferation, which might correlate to the regulatory role of miR-141 and AKT/mTOR signal pathway, suggesting that MEG3 holds great promise as a therapeutic strategy for RA. +genetics_overexpression_promote 31410981 hsa-mir-488 Prostatic Neoplasms Moreover, CCK-8, EdU, glucose uptake, and lactate secrete assays revealed that overexpression of miR-488 in PCa cell lines PC3 and DU145 resulted in inhibition of proliferation and glycolysis. +virus_miRNA 31410940 bkv-mir-B1 Kidney Transplantation BKV-miR-B1-5p and BKV-miR-B1-3p showed a 1000-fold increase over 12 days but did not prevent cell lysis. +transcription factor target 31410940 hsa-mir-10 Bk Virus Infections In conclusion, BKV infection results in regulation of cellular genes regulated by and possibly amenable to therapies targeting miR-10 and miR-30. +circulation_biomarker_diagnosis_ns 31410930 hsa-mir-182 Pre-Eclampsia miR-182 was one of the first miRNAs described as elevated in the serum and placentas of preeclamptic women. +lncRNA target 31410930 hsa-mir-182 Ovarian Neoplasms Furthermore, miR-182 has been shown to target BRCA1 mRNA in ovarian cancer cells, blocking the formation of the BRCA1 repressor complex and allowing increased transcription of HMGA2. +lncRNA target 31410746 hsa-mir-142 Diabetes Mellitus 5p/PTEN via PI3K/AKT/mTOR pathway in NRK-52E cells. +genetics_overexpression_promote 31410735 hsa-mir-638 Breast Neoplasms The miR-638 overexpression inhibited the breast tumor growth. +lncRNA target 31410369 hsa-mir-27a Ovarian Neoplasms However, the role and mechanism of miR-27a-3p in ovarian cancer are still unknown. Therefore, miR-27a-3p/BTG1 axis may be a new potential target for the treatment of ovarian cancer. +other 31410300 hsa-mir-1906 Neuralgia CONCLUSION: miR-1906 gene stimulation reduced neuropathic pain by enhancing Akt/nTOR/PI3K and TLR-4/NF-kappaB pathway regulation. +lncRNA target 31410215 hsa-mir-124 Arthritis, Rheumatoid Conclusions: M-PHMs/miR-124 was highly effective against RA through therapeutic synergy. +genetics_GWAS 31410206 hsa-mir-150 Carcinoma, Non-Small-Cell Lung c-myc gene was identified as a miR-150 transcriptional factor which increased miR-150 accumulation, therefore pharmacologically or genetically inhibiting c-myc/miR-150 expression significantly inhibited NSCLC cell growth in vitro and in vivo. +lncRNA target 31410193 hsa-mir-21 Pheochromocytoma We propose miR3p to select mPPGL patients who may benefit from mTOR inhibitors. +lncRNA target 31410193 hsa-mir-21 Paraganglioma We propose miR3p to select mPPGL patients who may benefit from mTOR inhibitors. +genetics_knock down_suppress 31410182 hsa-mir-134 Uterine Cervical Neoplasms Knockdown of miR-134 attenuated the inhibitory effects of NCK1-AS1 downregulation on the proliferation and migration of cervical cancer cells. +genetics_knock down_promote 31410179 hsa-mir-503 Retinoblastoma PTPN12 knockdown could therefore abrogate the effects of miR-503 downregulation in RB cells. +other 31410172 hsa-mir-520a Reperfusion Injury Results revealed that NEAT1 was significantly upregulated and miR-520a was downregulated in the ischemia/reperfusion myocardium and the cardiomyocytes that received H/R treatment. +lncRNA target 31410153 hsa-mir-448 Carcinoma, Non-Small-Cell Lung These findings suggested that the progression of NSCLC may be controlled by miR-448, which appears to hold promise as a therapeutic target for patients with NSCLC. +lncRNA target 31410149 hsa-mir-6852 Glioma The present findings suggested that miR-6852 inhibited glioma cells proliferation, migration and invasion by targeting the suppression of LEF1. +circulation_biomarker_diagnosis_ns 31410131 hsa-mir-29a Myocardial Infarction, Acute The authors also measured the level of miR-29a-3p in the plasma of 100 acute myocardial infarction (AMI) patients and found that circulating miR-29a-3p was significantly decreased in AMI patients. Receiver operating characteristic curve analysis showed that miR-29a-3p could be used to screen AMI patients from healthy controls. +lncRNA target 31410122 hsa-mir-934 Carcinoma, Small Cell 5p, as a tumor suppressor in NSCLC, may promote the sensitivity of cells to DDP by targeting TP53INP1, associated with the suppression of cell proliferation and promotion of apoptosis. +other 31410122 hsa-mir-934 Nondisjunction, Genetic In addition, it has been reported that hsa-microRNA (miR)-3934 serves key roles in various types of lung cancer, including small-cell lung carcinomas (SCLC) and non-SCLC (NSCLC). +other 31410122 hsa-mir-934 Small Cell Lung Carcinoma In addition, it has been reported that hsa-microRNA (miR)-3934 serves key roles in various types of lung cancer, including small-cell lung carcinomas (SCLC) and non-SCLC (NSCLC). +other 31410122 hsa-mir-934 Lung Neoplasms In addition, it has been reported that hsa-microRNA (miR)-3934 serves key roles in various types of lung cancer, including small-cell lung carcinomas (SCLC) and non-SCLC (NSCLC). +lncRNA target 31410122 hsa-mir-934 Carcinoma, Non-Small-Cell Lung 5p, as a tumor suppressor in NSCLC, may promote the sensitivity of cells to DDP by targeting TP53INP1, associated with the suppression of cell proliferation and promotion of apoptosis. +other 31410115 hsa-mir-454 Pancreatic Carcinoma 5p) were selected to generate a signature. +other 31410115 hsa-mir-5586 Pancreatic Carcinoma 5p) were selected to generate a signature. +other 31410115 hsa-mir-613 Pancreatic Carcinoma 5p) were selected to generate a signature. +other 31410115 hsa-mir-424 Pancreatic Carcinoma 5p) were selected to generate a signature. +other 31410115 hsa-mir-1271 Pancreatic Carcinoma 5p) were selected to generate a signature. +lncRNA target 31410057 hsa-mir-625 Stomach Neoplasms Conclusion: miR-625 reverses MDR in gastric cancer cells by targeting ALDH1A1. +genetics_knock down_promote 31410019 hsa-mir-34c Carcinoma, Non-Small-Cell Lung Overexpression of miR-34c or knockdown of HMGB1 inhibited cell proliferation, promoted cell apoptosis, and induced ER stress in NSCLC cells. +genetics_overexpression_promote 31410016 hsa-mir-937 Breast Neoplasms miR-937 overexpression promoted the viability, down-regulated the G1 phase ratios and increased the ability of colony formation in breast cancer cells. +transcription factor target 31409971 hsa-mir-664 Uterine Cervical Neoplasms Therefore, miR-664 might be a potential therapeutic target for the treatment of patients with cervical cancer. +circRNA target 31409903 hsa-mir-136 Stomach Neoplasms Rescue experiments confirmed that circOSBPL10 regulates biological functions in GC cells via a circOSBPL10-miR5p-WNT2 axis. +lncRNA target 31409837 hsa-mir-137 Schizophrenia The MIR137HG gene encoding microRNA-137 (miR-137) is genome-wide associated with schizophrenia (SZ), however, the underlying molecular mechanisms remain unknown. These findings shed further light on the risk architecture of the miR-137 region and provide a novel regulatory mechanism through VNTR length and alternative MIR137HG transcripts which contribute to risk for SZ. +genetics_overexpression_promote 31409777 hsa-mir-545 Glioma Forced overexpression of miR-545 mimicked circPRKCI shRNA-induced actions, inhibiting glioma cell survival and proliferation. +lncRNA target 31409775 hsa-mir-199a Thyroid Cancer, Papillary The oncogenic role of ABHD11-AS1 and its regulation of miR-199a-5p in PTC were examined by biological assays. Taken together, the data show that ABHD11-AS1 acts as a competing endogenous RNA (ceRNA) to exert malignant properties in PTC through the miR-199a-5p/SLC1A5 axis. +genetics_overexpression_promote 31409772 hsa-mir-876 Cholangiocarcinoma BCL-XL overexpression reversed the miR-876 mediated effect on CCA cell growth and apoptosis. +other 31409759 hsa-mir-29c Carcinoma, Renal Cell Functional experiments showed that DUXAP8 and DUXAP9 enhanced but miR-29c-3p weakened growth of renal cell carcinoma. +lncRNA target 31409724 hsa-mir-497 Stomach Neoplasms Inhibition of miR +other 31409641 hsa-mir-17 Colorectal Neoplasms Here, we identified an immune-related lncRNA, MIR17HG, whose expression was gradually upregulated in adjacent, adenoma, and colorectal cancer tissue. +circulation_biomarker_diagnosis_ns 31409426 hsa-mir-17 Lumbar Radicular Pain METHODS: In a cohort of 97 patients with leg pain and disc herniation verified on MRI, we investigated the association between circulating miR-17 and leg pain intensity. +circulation_biomarker_diagnosis_up 31409059 hsa-mir-574 Aortic Aneurysm, Thoracic 5p serum levels discriminated TAA patients from controls with an area under the receiver operating characteristic curve of 0.87. +other 31408567 hsa-mir-155 Liver Diseases 5p, which canonically downregulates the caveola component, polymerase I and transcript release factor (PTRF), a gene previously implicated in hepatic energy metabolism. +other 31408567 hsa-mir-1968 Liver Diseases 5p, which canonically downregulates the caveola component, polymerase I and transcript release factor (PTRF), a gene previously implicated in hepatic energy metabolism. +genetics_overexpression_promote 31408273 hsa-mir-9 Carcinoma, Hepatocellular In addition, it was demonstrated that overexpression of miR-9 suppressed the proliferative and migratory capacity of HCC cells and impaired cell cycle progression. +other 31408236 hsa-mir-132 Epilepsy, Temporal Lobe miR-132 is one of the most commonly upregulated miRs in animal TLE models with important roles shown in neurons. The aim of this study was to characterize the cell-type specific expression of miR-132 in the hippocampus of patients with TLE and during epileptogenesis in a rat TLE model. +lncRNA target 31408201 hsa-mir-203a Diabetic Retinopathy In conclusion, our findings demonstrate that up-regulation of miR-203a-3p might inhibit pathological retinal angiogenesis of PDR by targeting VEGFA and HIF-1alpha. +lncRNA target 31408201 hsa-mir-203a Diabetic Retinopathy In conclusion, our findings demonstrate that up-regulation of miR-203a-3p might inhibit pathological retinal angiogenesis of PDR by targeting VEGFA and HIF-1alpha. +lncRNA target 31407919 hsa-mir-1285 Diabetes Mellitus, Type 2 The present study is useful to elucidate the molecular mechanism of MiR5p in type 2 DM and its role in disease progression and we discovered miR-1285 as a novel prognostic, diagnostic and therapeutic target for type 2 DM. +circulation_biomarker_diagnosis_up 31407670 hsa-mir-21 Diabetes Mellitus, Type 2 The serum biomarkers BNP (B-type natriuretic peptide), Gal-3 (Galectin-3), GDF-15 (growth differentiation factor-15), sST2 (soluble suppression of tumorigenicity 2), OPG (osteoprotegerin), and microRNA 19b and 21 will be sampled from patients undergoing aortic valve replacement (with and without T2DM), patients with T2DM but without aortic valve disease and healthy volunteers. +circulation_biomarker_diagnosis_up 31407670 hsa-mir-19b Diabetes Mellitus, Type 2 The serum biomarkers BNP (B-type natriuretic peptide), Gal-3 (Galectin-3), GDF-15 (growth differentiation factor-15), sST2 (soluble suppression of tumorigenicity 2), OPG (osteoprotegerin), and microRNA 19b and 21 will be sampled from patients undergoing aortic valve replacement (with and without T2DM), patients with T2DM but without aortic valve disease and healthy volunteers. +circulation_biomarker_diagnosis_up 31407670 hsa-mir-19b Aortic Valve Stenosis The serum biomarkers BNP (B-type natriuretic peptide), Gal-3 (Galectin-3), GDF-15 (growth differentiation factor-15), sST2 (soluble suppression of tumorigenicity 2), OPG (osteoprotegerin), and microRNA 19b and 21 will be sampled from patients undergoing aortic valve replacement (with and without T2DM), patients with T2DM but without aortic valve disease and healthy volunteers. +circulation_biomarker_diagnosis_up 31407670 hsa-mir-21 Aortic Valve Stenosis The serum biomarkers BNP (B-type natriuretic peptide), Gal-3 (Galectin-3), GDF-15 (growth differentiation factor-15), sST2 (soluble suppression of tumorigenicity 2), OPG (osteoprotegerin), and microRNA 19b and 21 will be sampled from patients undergoing aortic valve replacement (with and without T2DM), patients with T2DM but without aortic valve disease and healthy volunteers. +other 31407591 hsa-mir-101 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: Collectively, our results demonstrated that circZFR exhibited a carcinogenic role by sponging miR3p and regulating CUL4B expression in NSCLC. +lncRNA target 31407409 hsa-mir-455 Pulmonary Fibrosis 3p, which inhibited Bax expression in IPF. +other 31407404 hsa-mir-143 Uterine Cervical Neoplasms miR-143/-4636 appeared specific for cervical cancer compared with cervical intraepithelial neoplasia (P < .001). +other 31407404 hsa-mir-4636 Uterine Cervical Neoplasms In our study, we found a combination of miR-143 and miR-4636 that is independently and strongly associated with cervical cancer prognosis and can be used as a clinically prognostic factor. +circRNA target 31407396 hsa-mir-516b Glioma Briefly, the regulatory network of circ-CDC45/miR-516b/miR-527 plays a pivotal role in GM tumorigenesis and may act as a potential target for GM treatment. +circRNA target 31407396 hsa-mir-527 Glioma Briefly, the regulatory network of circ-CDC45/miR-516b/miR-527 plays a pivotal role in GM tumorigenesis and may act as a potential target for GM treatment. +other 31406649 hsa-mir-278 Encephalopathy, Bovine Spongiform Integrated analysis of miRNA-mRNA expression showed that the most abundant DE miRNAs were miR-14 and miR-278 in BSE vs. NBSE and BSB vs. NBSB, respectively. +other 31406649 hsa-mir-14 Encephalopathy, Bovine Spongiform Integrated analysis of miRNA-mRNA expression showed that the most abundant DE miRNAs were miR-14 and miR-278 in BSE vs. NBSE and BSB vs. NBSB, respectively. +epigenetics 31406565 hsa-mir-7 Carcinoma, Non-Small-Cell Lung The aim of the present study is to provide clinical insights associated with this novel potential biomarker in NSCLC patients by comparing the miR-7 methylation status with the cisplatin treatment response. In conclusion, our results show that presence of miR-7 methylation in early-stage NSCLC is suggestive of aggressive behavior, especially for adenocarcinoma patients. +genetics_overexpression_promote 31406464 hsa-mir-106b Carcinoma, Hepatocellular miR-106b-5p overexpression may promote HCC cell proliferation and invasion by suppressing FOG2, implying its potentials as a promising therapeutic target for HCC patients. +exosome 31406207 hsa-mir-16 Mesothelioma, Malignant We discovered that the most abundant miRNAs in MM cancer exosomes were tumor suppressors, particularly miR5p. +other 31406139 hsa-mir-375 Carcinoma, Hepatocellular In conclusion, the results of the current study demonstrated that VitD can re-sensitize HCC cells resistant to EVE treatment triggering miR-375 up-regulation and consequently down-regulating several oncogenes responsible of EMT and drug resistance. +transcription factor target 31405989 hsa-mir-30 Inflammation Therefore, together, our data establish the competitive interplay between HuR and miR-330 as a mechanism via which muscle fibers modulate, in part, STAT3 expression to determine their fate in response to promoters of muscle wasting. +circulation_biomarker_diagnosis_ns 31405809 hsa-mir-155 Pneumonia Collectively, our data suggest the important role of circulating exosomes secreted into peripheral blood as a key mediator of septic lung injury via exosome-shuttling miR-155. +genetics_knock down_promote 31405759 hsa-mir-653 Colonic Neoplasms qRT-PCR and western blot demonstrated that miR-3653 suppressed the epithelial-mesenchymal transition (EMT) of colon cancer cells using both gain- and loss- of function assay. +lncRNA target 31405216 hsa-mir-181a Osteoarthritis Visfatin confirms its ability to induce apoptosis and oxidative stress in human OA chondrocytes; these effects appeared mediated by miR-34a and miR-181a via NF-kappaB pathway. +lncRNA target 31405216 hsa-mir-34a Osteoarthritis Visfatin confirms its ability to induce apoptosis and oxidative stress in human OA chondrocytes; these effects appeared mediated by miR-34a and miR-181a via NF-kappaB pathway. +transcription factor target 31404910 hsa-mir-155 Sciatic Neuropathy miR-155 silencing was found to alleviate sciatic nerve injury in DPN, highlighting its potential as a therapeutic target for DPN. +transcription factor target 31404910 hsa-mir-155 Diabetic Neuropathies miR-155 silencing was found to alleviate sciatic nerve injury in DPN, highlighting its potential as a therapeutic target for DPN. +other 31404908 hsa-mir-150 Precursor Cell Lymphoblastic Leukemia-Lymphoma Among the network, 10 RNAs (LINC00471, hsa-mir-100, hsa-mir-150, ANP32E, ERMP1, MYO1B, PAPD7, PTGIS, TERF1, and VEGFA) was associated with high-risk group of childhood AML and functions were significant for prognosis. +other 31404908 hsa-mir-100 Precursor Cell Lymphoblastic Leukemia-Lymphoma Among the network, 10 RNAs (LINC00471, hsa-mir-100, hsa-mir-150, ANP32E, ERMP1, MYO1B, PAPD7, PTGIS, TERF1, and VEGFA) was associated with high-risk group of childhood AML and functions were significant for prognosis. +genetics_knock down_suppress 31404776 hsa-mir-212 Thyroid Cancer, Papillary Repression of miR-212 partly abrogated the inhibitory effects of MIAT knockdown on PTC cells. +lncRNA target 31404595 hsa-mir-29c Hepatitis, Alcoholic In addition, miR-29c is one of the major down-regulated miRNAs in AH, targeting FOS. +genetics_knock down_promote 31404330 hsa-mir-1246 Uterine Cervical Neoplasms Furthermore, MMP2 and MMP9 levels were downregulated, whereas components of the ECM were upregulated subsequent to miR-1246 knockdown, indicating that this miRNA regulates cervical cancer cell pathogenesis via the THBS2/MMP/ECM pathway. +lncRNA target 31404303 hsa-mir-29c Carcinoma, Endometrioid The present results suggested that miR-29c may be a potential therapeutic target for endometrial cancer. +lncRNA target 31404303 hsa-mir-29c Endometrial Neoplasms The present results suggested that miR-29c may be a potential therapeutic target for endometrial cancer. +other 31404302 hsa-mir-485 Cholangiocarcinoma 5p expression in CCA tissues. +genetics_overexpression_suppress 31403943 hsa-mir-539 Stomach Neoplasms Furthermore, overexpression of miR-539 inhibited cell proliferation, migration, and invasion of gastric cancer cells. +genetics_knock down_promote 31403941 hsa-mir-214 Prostatic Neoplasms Loss expression of miR +transcription factor target 31403686 hsa-mir-142 Nervous System Diseases Furthermore, we found that 2 of the 3 miRNAs, miR3p, and miR-466b-5p, have the same target gene, Capn6, an antiapoptotic gene that is tightly regulated in the pathogenesis of neurological diseases. +other 31403686 hsa-mir-142 Ichthyosis, Lamellar Collectively, we have shown that a number of miRNAs change in oligodendrocyte precursor cells in response to HI insult in developing brains, and miR3p/miR-466b-5p/Capn6 pathway might affect the pathogenesis of WMI, providing us new clues for the diagnosis and therapy for WMI. +other 31403686 hsa-mir-466b Ichthyosis, Lamellar Collectively, we have shown that a number of miRNAs change in oligodendrocyte precursor cells in response to HI insult in developing brains, and miR3p/miR-466b-5p/Capn6 pathway might affect the pathogenesis of WMI, providing us new clues for the diagnosis and therapy for WMI. +other 31403686 hsa-mir-466b Welander distal myopathy, Swedish type Collectively, we have shown that a number of miRNAs change in oligodendrocyte precursor cells in response to HI insult in developing brains, and miR3p/miR-466b-5p/Capn6 pathway might affect the pathogenesis of WMI, providing us new clues for the diagnosis and therapy for WMI. +other 31403686 hsa-mir-142 Welander distal myopathy, Swedish type Collectively, we have shown that a number of miRNAs change in oligodendrocyte precursor cells in response to HI insult in developing brains, and miR3p/miR-466b-5p/Capn6 pathway might affect the pathogenesis of WMI, providing us new clues for the diagnosis and therapy for WMI. +transcription factor target 31403686 hsa-mir-466b Nervous System Diseases Furthermore, we found that 2 of the 3 miRNAs, miR3p, and miR-466b-5p, have the same target gene, Capn6, an antiapoptotic gene that is tightly regulated in the pathogenesis of neurological diseases. +lncRNA target 31403340 hsa-mir-211 Squamous Cell Carcinoma of Head and Neck Finally, ALP inhibited tumor growth and increased miR +tissue_expression_down 31403184 hsa-mir-139 Thyroid Neoplasms 5p downexpression in primary carcinomas from patients with recurrent/metastatic disease compared to disease-free patients, sustained in paired local metastases and validated in publicly available thyroid cancer series. +lncRNA target 31402962 hsa-mir-22 Colorectal Neoplasms In conclusion, MIR22HG may regulate PCSK5, BTK and PDK4, and RP11-61I13.3 may regulate the ANK2, GBP2, PCSK5 through sponging miRNAs to act on the progression of CRC, and the potential function of these genes have been revealed. +other 31402960 hsa-mir-181c Neuroblastoma miR-181c has certain clinical significance in evaluating pathogenesis, early diagnosis and treatment of patients with neuroblastoma. +circulation_biomarker_prognosis_up 31402959 hsa-mir-198 Adenocarcinoma of Lung 5p was associated with the age, blood vessel invasion, Tumor-Node-Metastasis stage, and lymph node metastasis of patients with LUAD and served as an independent prognostic factor for survival. +genetics_overexpression_promote 31402954 hsa-mir-296 Carcinoma, Non-Small-Cell Lung Overexpression of miR +genetics_overexpression_promote 31402949 hsa-mir-148a Colorectal Neoplasms It was discovered that miR-148a was overexpressed while ErbB3 expression was low in colorectal cancer, and the mRNA level of miR-148a had a negative correlation with the expression of ErbB3. +circulation_biomarker_diagnosis_ns 31402934 hsa-mir-363 Colorectal Neoplasms The expression of RUNX3 gene and miR-363 in peripheral blood of patients with colorectal cancer was lower than in the normal controls. +circulation_biomarker_prognosis_up 31402930 hsa-mir-486 Carcinoma, Non-Small-Cell Lung 5p was further validated to be significantly downregulated in additional nonsmall cell lung cancer (NSCLC) tissue, serum, and cell samples by quantitative reverse transcription-polymerase chain reaction (RT-PCR), and the expression level of miR +transcription factor target 31402791 hsa-mir-140 Carcinoma, Hepatocellular We further confirmed that FEN1 was a direct target of miR +genetics_knock down_suppress 31402756 hsa-mir-153 Pancreatic Carcinoma miR-153 inhibition exerted an opposing effect on HIF1A-mediated immune escape of PC cells to circ_0000977 knockdown; the effect of circ_0000977 knockdown were partially attenuated by miR-153 inhibition. In summary, circ_0000977/miR-153 axis modulates HIF1A-mediated immune escape of PC cells through miR-153 downstream targets HIF1A and ADAM10. +lncRNA target 31402560 hsa-mir-367 Neuroectodermal Tumors, Primitive Here, we show that (a) miR-367 is carried in microvesicles derived from embryonal CNS tumor cells expressing OCT4A; and (b) inhibition of miR-367 in these cells attenuates their aggressive traits. Our findings reveal possible clinical applications of a cancer stemness pathway, highlighting miR-367 as a putative liquid biopsy biomarker that could be further explored to improve early diagnosis and prognosis prediction, and potentially serve as a therapeutic target in aggressive embryonal CNS tumors. +lncRNA target 31402556 hsa-mir-5590 Carcinoma, Hepatocellular In conclusion, our study demonstrates that a SOX9-AS1/miR3p/SOX9 positive feedback loop drives tumor growth and metastasis in HCC through the Wnt/beta-catenin pathway, suggesting SOX9-AS1 as a novel potential prognostic and treatment target for HCC. +lncRNA target 31402547 hsa-mir-127 Osteoarthritis Our study demonstrated that Circ_0136474 and MMP-13 suppressed cell proliferation, while enhanced cell apoptosis by competitive binding to miR +genetics_overexpression_suppress 31401948 hsa-mir-1254 Squamous Cell Carcinoma of Head and Neck We examined the expression levels of miR-1254 in oral squamous cell carcinoma tissue samples and cell line.Proliferation and invasion assays were performed in oral squamous cell carcinoma cells with miR-1254 overexpression or underexpression. +exosome 31401755 hsa-mir-7 Acquired Immunodeficiency Syndrome Herein, we demonstrate that exposure of astrocytes to HIV-1 protein Tat mediates the induction and release of extracellular vesicle (EV) microRNA-7 (miR-7) that is taken up by neurons, leading in turn, to downregulation of neuronal neuroligin 2 (NLGN2) and ultimately to synaptic alterations. +other 31401416 hsa-mir-195 Venous Thromboembolism CONCLUSIONS: MicroRNAs may act as novel diagnostic biomarkers for VTE, and miR-1233, miR-134, miR-145, miR3p, miR-582, miR-532, and miR-195 are prime candidates. +other 31401416 hsa-mir-1233 Venous Thromboembolism CONCLUSIONS: MicroRNAs may act as novel diagnostic biomarkers for VTE, and miR-1233, miR-134, miR-145, miR3p, miR-582, miR-532, and miR-195 are prime candidates. +other 31401416 hsa-mir-483 Venous Thromboembolism CONCLUSIONS: MicroRNAs may act as novel diagnostic biomarkers for VTE, and miR-1233, miR-134, miR-145, miR3p, miR-582, miR-532, and miR-195 are prime candidates. +other 31401416 hsa-mir-134 Venous Thromboembolism CONCLUSIONS: MicroRNAs may act as novel diagnostic biomarkers for VTE, and miR-1233, miR-134, miR-145, miR3p, miR-582, miR-532, and miR-195 are prime candidates. +other 31401416 hsa-mir-145 Venous Thromboembolism CONCLUSIONS: MicroRNAs may act as novel diagnostic biomarkers for VTE, and miR-1233, miR-134, miR-145, miR3p, miR-582, miR-532, and miR-195 are prime candidates. +circulation_biomarker_diagnosis_up 31401213 hsa-mir-23b Myasthenia Gravis "Our overall findings thus revealed a blood ""miR-323b-3p," +lncRNA target 31401194 hsa-let-7 Cardiomyopathies Furthermore, microRNA let-7 and Tgfbr3 may serve as therapeutic targets and biomarkers for myocardial damage. +lncRNA target 31401194 hsa-let-7 Cardiomegaly Inhibition of let-7 exacerbated cardiomyocyte apoptosis, induced a cardiac hypertrophic phenotype, and resulted in worsened left ventricular ejection fraction. +circulation_biomarker_diagnosis_down 31401194 hsa-let-7 Myocardial Infarction We also observed a reduction of let-7a and let-7f in plasma of MI patients and pigs. +circulation_biomarker_diagnosis_down 31401194 hsa-let-7a Myocardial Infarction FINDINGS: MicroRNAs let-7a and let-7f were significantly downregulated in the infarct area within 24h post-MI in pigs. We also observed a reduction of let-7a and let-7f in plasma of MI patients and pigs. +circulation_biomarker_diagnosis_down 31401194 hsa-let-7f Myocardial Infarction FINDINGS: MicroRNAs let-7a and let-7f were significantly downregulated in the infarct area within 24h post-MI in pigs. We also observed a reduction of let-7a and let-7f in plasma of MI patients and pigs. +lncRNA target 31401160 hsa-mir-33a Esophageal Squamous Cell Carcinoma This study highlights the functions of miR-33a-5p in the progression of ESCC and suggests that the DANCR/miR-33a-5p/ZEB1 axis may be a potential prognostic and therapeutic target. +lncRNA target 31401158 hsa-mir-33a Carcinoma, Hepatocellular CASC15 upregulated TWIST1 gene expression in HCC cells by sponging miR-33a-5p. a CASC15 could promote EMT and facilitate malignancy of HCC cells by increasing TWIST1 gene expression via miR-33a-5p sponging. +genetics_overexpression_promote 31401147 hsa-mir-602 Esophageal Squamous Cell Carcinoma Subsequently, miR-602 overexpression promoted ESCC proliferation and metastasis and regulated cell cycles in vitro and in vivo. +lncRNA target 31400934 hsa-mir-16 Pancreatic Carcinoma Total RNA was extracted using the miRNeasy Mini Kit and the expression of miRs frequently dysregulated in pancreatobiliary cancer (miR-16, miR-21, miR-196a, miR-221) were analyzed by quantitative real-time PCR using RNU6B as internal control. +lncRNA target 31400934 hsa-mir-196a Pancreatic Carcinoma Total RNA was extracted using the miRNeasy Mini Kit and the expression of miRs frequently dysregulated in pancreatobiliary cancer (miR-16, miR-21, miR-196a, miR-221) were analyzed by quantitative real-time PCR using RNU6B as internal control. +lncRNA target 31400934 hsa-mir-221 Pancreatic Carcinoma Total RNA was extracted using the miRNeasy Mini Kit and the expression of miRs frequently dysregulated in pancreatobiliary cancer (miR-16, miR-21, miR-196a, miR-221) were analyzed by quantitative real-time PCR using RNU6B as internal control. +lncRNA target 31400934 hsa-mir-21 Pancreatic Carcinoma Total RNA was extracted using the miRNeasy Mini Kit and the expression of miRs frequently dysregulated in pancreatobiliary cancer (miR-16, miR-21, miR-196a, miR-221) were analyzed by quantitative real-time PCR using RNU6B as internal control. +genetics_overexpression_suppress 31400752 hsa-mir-27a Carcinoma, Renal Cell Both overexpressed ADAMTS9-AS2 and underexpressed miR-27a-3p in ccRCC cell lines led to the inhibition of cell proliferation and the reduction of chemoresistance. Collectively, these results suggest ADAMTS9-AS2 inhibits the progression and impairs the chemoresistance of ccRCC via miR-27a-3p-mediated regulation of FOXO1 and may serve as a prognostic biomarker and therapeutic target for ccRCC. +genetics_overexpression_promote 31400610 hsa-mir-199a Anemia, Aplastic In this study, we found that microRNA 199a-5p (miR-199a-5p) exhibits significantly higher expression in AA BM-MSCs compared with the normal control and is demonstrated to facilitate adipogenic differentiation of BM-MSCs through lentivirus-mediated miR-199a overexpression. +lncRNA target 31400609 hsa-mir-421 Glioma Moreover, transcription factor SP1 activated the transcription of VEGFA, constructing the circSCAF11/miR-421/SP1/VEGFA axis in the glioma genesis. The findings in this research illustrate that circSCAF11 accelerates glioma tumorigenesis through the miR-421/SP1/VEGFA axis, providing a potential target for circRNA and glioma treatment. +lncRNA target 31400606 hsa-mir-214 Diabetic Cardiomyopathies Therefore, this study elucidated that CACR might be a novel therapeutic target via the CACR/miR +genetics_knock down_suppress 31400488 hsa-mir-206 Subarachnoid Hemorrhage knockdown exosomes has a greater neuroprotective effect on SAH-induced EBI compared to treatment with simple exosomes. +genetics_knock down_suppress 31400488 hsa-mir-206 Brain Injuries knockdown exosomes has a greater neuroprotective effect on SAH-induced EBI compared to treatment with simple exosomes. +other 31400480 hsa-mir-10b Breast Neoplasms RESULTS: In women with breast cancer versus healthy controls, the expression of some oncomiRs was significantly increased - miR-21 (P<0.001), miR-155 (P=0.001), miR-221 (P=0.008), miR-27a (P<0.001), and miR-10b (P=0.007) - and that of some TSmiRs was significantly decreased - miR-206 (P=0.048), miR-145 (P=0.011), miR-143 (P=0.008), miR-9 (P=0.020), and let-7a (P=0.005). +other 31400480 hsa-mir-143 Breast Neoplasms RESULTS: In women with breast cancer versus healthy controls, the expression of some oncomiRs was significantly increased - miR-21 (P<0.001), miR-155 (P=0.001), miR-221 (P=0.008), miR-27a (P<0.001), and miR-10b (P=0.007) - and that of some TSmiRs was significantly decreased - miR-206 (P=0.048), miR-145 (P=0.011), miR-143 (P=0.008), miR-9 (P=0.020), and let-7a (P=0.005). +other 31400480 hsa-mir-206 Breast Neoplasms RESULTS: In women with breast cancer versus healthy controls, the expression of some oncomiRs was significantly increased - miR-21 (P<0.001), miR-155 (P=0.001), miR-221 (P=0.008), miR-27a (P<0.001), and miR-10b (P=0.007) - and that of some TSmiRs was significantly decreased - miR-206 (P=0.048), miR-145 (P=0.011), miR-143 (P=0.008), miR-9 (P=0.020), and let-7a (P=0.005). +other 31400480 hsa-mir-27a Breast Neoplasms RESULTS: In women with breast cancer versus healthy controls, the expression of some oncomiRs was significantly increased - miR-21 (P<0.001), miR-155 (P=0.001), miR-221 (P=0.008), miR-27a (P<0.001), and miR-10b (P=0.007) - and that of some TSmiRs was significantly decreased - miR-206 (P=0.048), miR-145 (P=0.011), miR-143 (P=0.008), miR-9 (P=0.020), and let-7a (P=0.005). +other 31400480 hsa-let-7a Breast Neoplasms RESULTS: In women with breast cancer versus healthy controls, the expression of some oncomiRs was significantly increased - miR-21 (P<0.001), miR-155 (P=0.001), miR-221 (P=0.008), miR-27a (P<0.001), and miR-10b (P=0.007) - and that of some TSmiRs was significantly decreased - miR-206 (P=0.048), miR-145 (P=0.011), miR-143 (P=0.008), miR-9 (P=0.020), and let-7a (P=0.005). +other 31400480 hsa-mir-155 Breast Neoplasms RESULTS: In women with breast cancer versus healthy controls, the expression of some oncomiRs was significantly increased - miR-21 (P<0.001), miR-155 (P=0.001), miR-221 (P=0.008), miR-27a (P<0.001), and miR-10b (P=0.007) - and that of some TSmiRs was significantly decreased - miR-206 (P=0.048), miR-145 (P=0.011), miR-143 (P=0.008), miR-9 (P=0.020), and let-7a (P=0.005). +other 31400480 hsa-mir-21 Breast Neoplasms RESULTS: In women with breast cancer versus healthy controls, the expression of some oncomiRs was significantly increased - miR-21 (P<0.001), miR-155 (P=0.001), miR-221 (P=0.008), miR-27a (P<0.001), and miR-10b (P=0.007) - and that of some TSmiRs was significantly decreased - miR-206 (P=0.048), miR-145 (P=0.011), miR-143 (P=0.008), miR-9 (P=0.020), and let-7a (P=0.005). +other 31400480 hsa-mir-221 Breast Neoplasms RESULTS: In women with breast cancer versus healthy controls, the expression of some oncomiRs was significantly increased - miR-21 (P<0.001), miR-155 (P=0.001), miR-221 (P=0.008), miR-27a (P<0.001), and miR-10b (P=0.007) - and that of some TSmiRs was significantly decreased - miR-206 (P=0.048), miR-145 (P=0.011), miR-143 (P=0.008), miR-9 (P=0.020), and let-7a (P=0.005). +genetics_knock down_promote 31400468 hsa-mir-26 Memory Disorders Our results showed that memory formation was associated with the down-regulated expression of miR-1, miR-10 and miR-26 in the PFC and the hippocampus, but not the amygdala. The PFC level of miR-10 and also hippocampal level of miR-1 and miR-10 were significantly up-regulated, while amygdala miR-1 and miR-26 were down-regulated in scopolamine-induced memory loss under stress. +exosome 31400405 hsa-mir-126 Mesothelioma, Malignant These findings suggest that transfer of miR-126 via HUVEC-derived exosomes represents a novel strategy to inhibit angiogenesis and cell growth in MM. +circulation_biomarker_diagnosis_ns 31400088 hsa-mir-21 Cerebral Hemorrhage, Age-Related In addition, serum miR5p levels were notably elevated in patients relative to healthy individuals and were correlated with National Institutes of Health Stroke Scale (NIHSS) scores and clinical outcomes. +other 31399867 hsa-mir-375 Stomach Neoplasms Analysis of a microarray dataset showed that the miRNA miR-196a-5p was significantly upregulated, while miR-374a-5p and miR-375 were downregulated in gastric cancer patients. +other 31399867 hsa-mir-374a Stomach Neoplasms Analysis of a microarray dataset showed that the miRNA miR-196a-5p was significantly upregulated, while miR-374a-5p and miR-375 were downregulated in gastric cancer patients. +other 31399867 hsa-mir-196a Stomach Neoplasms Analysis of a microarray dataset showed that the miRNA miR-196a-5p was significantly upregulated, while miR-374a-5p and miR-375 were downregulated in gastric cancer patients. +other 31399552 hsa-mir-1226 Breast Neoplasms CONCLUSIONS: Our study demonstrated that MiR210HG sponges miR3p to facilitate invasive breast cancer cell invasion and metastasis by regulating mucin-1c and EMT pathway, revealing the oncogenic role of MiR210HG in IBC cells. +genetics_knock down_promote 31399552 hsa-mir-210 Breast Neoplasms Knockdown of MiR210HG suppressed IBC cell invasion and metastasis both in vitro and in vivo. +genetics_knock down_promote 31399501 hsa-mir-5702 Triple Negative Breast Neoplasms Knockdown of miR-5702 reversed the suppressing influences of LUCAT1 depletion on TNBC progression. We validated that LUCAT1 induced tumorigenesis and metastasis of TNBC via miR-5702, which provided clues for improving the treatment of TNBC. +other 31399202 hsa-mir-192 Huntington Disease AIM: This study was carried out to evaluate the link between miRNA 192 and vascular calcification, pre-existing as well as newly occurring major adverse cardiovascular events, and mortality among hemodialysis patients who are also considered to be potential kidney transplant recipients. CONCLUSIONS: MiRNA 192 levels are significantly lower among patients experiencing cardiovascular events while on hemodialysis awaiting kidney transplantation. +other 31399202 hsa-mir-192 Cardiovascular Diseases CONCLUSIONS: MiRNA 192 levels are significantly lower among patients experiencing cardiovascular events while on hemodialysis awaiting kidney transplantation. +other 31399202 hsa-mir-192 Vascular Calcification AIM: This study was carried out to evaluate the link between miRNA 192 and vascular calcification, pre-existing as well as newly occurring major adverse cardiovascular events, and mortality among hemodialysis patients who are also considered to be potential kidney transplant recipients. Vascular calcification was measured in the aorta using computerized tomography scans, and micro RNA 192 was measured. +other 31398873 hsa-mir-34a Retinitis Moreover, hyperglycemia may utilize miR-34a-5p to induce some expression changes in PPARgamma. +lncRNA target 31398715 hsa-mir-27a Periodontitis RESULTS: LncRNA MEG3 and IGF1 were both down-regulated, while miR-27a-3p was up-regulated in periodontitis samples compared with healthy samples. CONCLUSION: Down-regulation of MEG3 suppressed osteogenic differentiation of PDLSCs through miR-27a-3p/IGF1 axis in periodontitis. +lncRNA target 31398705 hsa-mir-1 Aortic Aneurysm, Abdominal METHODS: Adult male Sprague-Dawley rats were subjected to microsurgery to create a coiled embolization aneurysm model, and were injected with miR-31a-5p agomir or a negative control agomir via the tail vein at a dose of 10 mg/kg per week for 4 weeks after IA induction. +other 31398664 hsa-mir-342 Fractures, Bone MicroRNA (miR)5p is a Notch downstream molecule, and its roles in fracture healing remain unclear. +circulation_biomarker_diagnosis_ns 31398659 hsa-mir-150 Acute Lung Injury Here, we found miR-150 expression was significantly reduced in the serum of patients with ARDS, and negatively associated with the disease severity and 28-day survival of ARDS. In conclusion, miR-150 alleviated LPS-induced acute lung injury via directly targeting AKT3 expression or regulating JNK and NF-kappaB pathways, which may be a promising therapeutic strategy to treat ALI/ARDS. +transcription factor target 31398620 hsa-mir-148b Liver Neoplasms FACS analysis and CLSM images displayed that the conjugated CC9 peptide improved the accumulation and penetration of the nanoparticles in HuH-7 liver cancer cells through binding with the target of miR-148b neuropilin-1(NRP-1) on the cell surface. The raised level of miR-148b in turn inhibited the expression of NRP-1 and suppressed the migration of HuH-7 liver cancer cells. +lncRNA target 31398620 hsa-mir-148b Carcinoma, Hepatocellular Hence, CC9-PEG-SSBPEI/miR-148b nanoparticles had the potential for targeting delivery of miR-148b and anti-metastasis of hepatocellular carcinoma (HCC) cells. +transcription factor target 31398620 hsa-mir-148b Hepatitis FACS analysis and CLSM images displayed that the conjugated CC9 peptide improved the accumulation and penetration of the nanoparticles in HuH-7 liver cancer cells through binding with the target of miR-148b neuropilin-1(NRP-1) on the cell surface. The raised level of miR-148b in turn inhibited the expression of NRP-1 and suppressed the migration of HuH-7 liver cancer cells. +genetics_overexpression_promote 31398406 hsa-mir-140 Glioblastoma In contrast, overexpression of CTSB decreased TMZ-induced glioma cell death, promoted the mesenchymal transition, and attenuated miRincreased TMZ cytotoxicity. +other 31398299 hsa-let-7f Endomyocardial Fibrosis Functional enrichment indicated that bta-miR-148a, bta-miR-143, bta-miR-10b, bta-let-7i, bta-let-7f, bta-let-7b, bta-miR-30a-5p, and bta-miR-100 were significantly associated with adipogenesis, suggesting these as candidate regulators for IMF deposition in buffalo. +transcription factor target 31398085 hsa-mir-206 Acquired Immunodeficiency Syndrome Previous studies demonstrated that chronic binge alcohol (CBA) administration decreases SC differentiation potential, myogenic gene expression, and miR-206 expression in simian immunodeficiency virus (SIV)-infected male rhesus macaques and that miR-206 targets the Class IIA histone deacetylase, HDAC4. +transcription factor target 31398085 hsa-mir-206 Simian Acquired Immunodeficiency Syndrome Previous studies demonstrated that chronic binge alcohol (CBA) administration decreases SC differentiation potential, myogenic gene expression, and miR-206 expression in simian immunodeficiency virus (SIV)-infected male rhesus macaques and that miR-206 targets the Class IIA histone deacetylase, HDAC4. +circRNA target 31397837 hsa-mir-140 Cardiomegaly CONCLUSIONS: Our data demonstrated that circRNA_000203 exacerbates cardiac hypertrophy via suppressing miR-26b-5p and miR3p leading to enhanced Gata4 levels. +circRNA target 31397837 hsa-mir-26b Cardiomegaly CONCLUSIONS: Our data demonstrated that circRNA_000203 exacerbates cardiac hypertrophy via suppressing miR-26b-5p and miR3p leading to enhanced Gata4 levels. +lncRNA target 31397599 hsa-mir-34a Diabetes Mellitus In conclusion, inhibition of microRNA-34a mediated protection of thymosin beta 4 in endothelial progenitor cells against advanced glycation endproducts by targeting B-cell lymphoma 2, which was helpful for understanding the therapeutic potential of thymosin beta 4 for diabetic patients. +lncRNA target 31397599 hsa-mir-34a Mitochondrial Diseases Treatment with thymosin beta 4 or transfection with microRNA-34a inhibitor enhanced cell viability, reduced apoptosis, abated oxidative stress, and attenuated mitochondrial dysfunction in endothelial progenitor cells exposed to advanced glycation endproducts. +lncRNA target 31397491 hsa-mir-383 Squamous Cell Carcinoma of Head and Neck 5p represents a novel and potential therapeutic target for the treatment of OSCC. +other 31397222 hsa-mir-125b Spinal Cord Injuries Objectives: The aim of the study was to determine the relationships between microRNA-20a and microRNA-125b expression and apoptosis and inflammation in a rat model of spinal cord injury (SCI) using microscopy, immunohistochemistry, and molecular biology. Although the results of this study suggest potential relationships between microRNA-20a and microRNA-125b expression and apoptosis and inflammation in SCI, further studies are needed to confirm microRNA-20a and microRNA-125b as biomarkers in SCI and to develop new strategies for the treatment of SCI. +genetics_GWAS 31397210 hsa-mir-940 Colorectal Neoplasms 5p - NAP1L2 mRNA may aid in CRC management.KEY MESSAGESThe extracellular RNAs provide a potential class of noninvasive biomarkers with high specificity, accuracy and stability for detection of CRC.We used insilico data analysis followed by qPCR for detection of differential NAP1L2 gene expression with the selected epigenetic regulators.Our data presented interesting biomarker panel (NAP1L2 gene, lncRNA-SNHG14 and hsa-miR +lncRNA target 31397203 hsa-mir-181a Multiple Myeloma This research was to study the effect of LncRNA MALAT1 on the proliferation and adhesion of myeloma cells and whether Long non-coding RNAs MALAT1(LncRNA MALAT1) plays its regulative role through Hippo-YAP signaling pathway by targeting miR-181a-5p. In conclusion, this study showed that LncRNA MALAT1 interference inhibited the proliferation and adhesion of myeloma cells by the up-regulation of miR-181a-5p through activating the Hippo-YAP signaling pathway. +lncRNA target 31396764 hsa-mir-27a Liver Neoplasms METHODS: In this study, we aimed to prepare SRF and anti-miRNA27a-loaded anti-GPC3 antibody targeted lipid nanoparticles to enhance the therapeutic efficacy against liver cancers. CONCLUSION: The CSL-based G-S27LN efficiently co-delivered anti-microRNA27a and SRF and therefore represents a promising therapy to treat liver cancer. +genetics_overexpression_promote 31396630 hsa-mir-211 Osteoarthritis 5p overexpression facilitated chondrocyte differentiation, along with the reduced pro-inflammatory cytokines level and the level of proteinases responsible for cartilage matrix degradation. +other 31396362 hsa-mir-206 Glioma Our results suggest that miR-206 plays a key role in the blockade of the WNT/beta-catenin signalling pathway by down-regulating FZD7 and may be a promising therapeutic agent against malignant glioma and other WNT-driven tumours. +lncRNA target 31396355 hsa-mir-223 Colonic Neoplasms 3p acts as an oncogenic microRNA in colon cancer through regulating EMT and PRDM1. +genetics_overexpression_suppress 31396353 hsa-mir-765 Breast Neoplasms Overexpression of microRNA-765 attenuates the malignant progression of BCa through negatively regulating EZH1. +circulation_biomarker_diagnosis_up 31396338 hsa-mir-223 Atherosclerosis We recently demonstrated that miR-223 is significantly upregulated both in atherosclerotic arteries and in the serum sample of ASO patients. RESULTS: miR-223 was significantly upregulated in both the arteries and serum samples from ASO patients. +circulation_biomarker_diagnosis_up 31396332 hsa-mir-182 Testicular Germ Cell Tumor 5p was significantly up-regulated in the serum and tissue samples of NSCLC patients. +genetics_knock down_promote 31396325 hsa-mir-574 Carcinoma, Ovarian Epithelial 3p in SKOV3 and CAOV3 cells. +genetics_overexpression_promote 31396320 hsa-mir-10a Carcinoma, Hepatocellular Compared to carcinoma-adjacent regions, MEG3 expression was downregulated in cancer regions of HCC samples; by contrast, miRNA-10a-5p was overexpressed in cancer regions compared to tumor-adjacent areas. +lncRNA target 31396316 hsa-mir-144 Arthritis In conclusions, moxibustion therapy plays a possible regulatory function in rebalancing Treg/Th17 cells by regulating miR3p and its target gene Hif1a to treat CIA. +other 31396209 hsa-mir-204 Diabetes Mellitus, Type 1 5p, both of which negatively regulate insulin secretion and cell survival and are highly expressed in pancreatic cells, in the context of type 1 diabetes (T1D) pathogenesis. +genetics_knock down_promote 31396209 hsa-mir-101 Diabetes Mellitus, Type 1 3p precedes loss of glucose homeostasis. +exosome 31395931 hsa-mir-630 Subarachnoid Hemorrhage We further compared the exosomal miR-630 of clinical patients between aSAH and normal hydrocephalus. Then we demonstrated that the expression of exosomal miR-630 was markedly reduced in the BCSF treated BMECs and the same phenomenon occurred in aSAH patients compared with normal hydrocephalus. +lncRNA target 31395342 hsa-mir-4429 Stomach Neoplasms Rescue assays demonstrated that miR-4429 inhibited GC progression through METTL3/SEC62 axis. Together, our study firstly revealed that miR-4429 prevented gastric cancer progression through targeting METTL3 to inhibit m(6)A-caused stabilization of SEC62, indicating miR-4429 as a promising target for treatment improvement for GC. +lncRNA target 31395079 hsa-mir-218 Pancreatic Carcinoma 5p downregulation partially reversed the tumor-suppressive effect of ANLN downregulation on pancreatic cancer cell progression. +other 31394878 hsa-mir-125 Avian Leukosis We previously showed that miR-125b is down-regulated in ALV-J-induced tumors. This study aimed to investigate the possible role of miR-125b in ALV-J-mediated infection and tumorigenesis. +other 31394878 hsa-mir-125b Avian Leukosis We previously showed that miR-125b is down-regulated in ALV-J-induced tumors. This study aimed to investigate the possible role of miR-125b in ALV-J-mediated infection and tumorigenesis. +transcription factor target 31394192 hsa-mir-222 Uveal melanoma The p-PI3K, p-Akt and MMP9 expressions were elevated in UM cells transfected with miR-222 mimics, and suppressed in the miR-222 inhibitor group. +genetics_knock down_suppress 31394128 hsa-mir-9 Multiple Sclerosis 5p overexpression were performed in LPS-induced BV2 cells. +transcription factor target 31393787 hsa-mir-21 Non-alcoholic Fatty Liver Disease Taken together, we show that PP2A may have protective roles, and its inhibition exacerbates NAFLD pathology via activating NOX2-dependent peroxynitrite generation, thus increasing miR21-induced pathology.NEW & NOTEWORTHY Protein phosphatase 2A inhibition causes nonalcoholic steatohepatitis (NASH) progression via NADPH oxidase 2. +other 31393559 hsa-mir-27a Aortic Valve Disease Expression of miR-23a, miR-34a, miR-34c, miR-133a, miR-146a, and miR-155 was increased, and expression of miR-27a and miR-204 was decreased in valve tissues from CAVS compared with those from AR. +other 31393559 hsa-mir-133a Aortic Valve Disease Expression of miR-23a, miR-34a, miR-34c, miR-133a, miR-146a, and miR-155 was increased, and expression of miR-27a and miR-204 was decreased in valve tissues from CAVS compared with those from AR. +other 31393559 hsa-mir-204 Aortic Valve Disease Expression of miR-23a, miR-34a, miR-34c, miR-133a, miR-146a, and miR-155 was increased, and expression of miR-27a and miR-204 was decreased in valve tissues from CAVS compared with those from AR. +other 31393559 hsa-mir-155 Aortic Valve Disease Expression of miR-23a, miR-34a, miR-34c, miR-133a, miR-146a, and miR-155 was increased, and expression of miR-27a and miR-204 was decreased in valve tissues from CAVS compared with those from AR. +other 31393559 hsa-mir-23a Aortic Valve Disease Expression of miR-23a, miR-34a, miR-34c, miR-133a, miR-146a, and miR-155 was increased, and expression of miR-27a and miR-204 was decreased in valve tissues from CAVS compared with those from AR. +other 31393559 hsa-mir-146a Aortic Valve Disease Expression of miR-23a, miR-34a, miR-34c, miR-133a, miR-146a, and miR-155 was increased, and expression of miR-27a and miR-204 was decreased in valve tissues from CAVS compared with those from AR. +other 31393559 hsa-mir-34c Aortic Valve Disease Expression of miR-23a, miR-34a, miR-34c, miR-133a, miR-146a, and miR-155 was increased, and expression of miR-27a and miR-204 was decreased in valve tissues from CAVS compared with those from AR. +other 31393351 hsa-mir-124 Sepsis Most importantly, lnc-NEAT1/miR-124 axis presented numerically increased predictive value for sepsis risk and survival compared to each index alone.Lnc-NEAT1/miR-124 axis correlates with increased sepsis risk, and associates with higher inflammation, deteriorative disease condition, and decreased survival in patients with sepsis. +genetics_overexpression_promote 31393166 hsa-mir-671 Osteosarcoma Overexpressed miR +genetics_knock down_promote 31393040 hsa-mir-140 Squamous Cell Carcinoma of Head and Neck 5p overexpression suppressed the growth of OSCC xenograft tumors by downregulating PAK4. +other 31392905 hsa-mir-122 Coronary Artery Disease The aim of this study was the evaluation of copy number variations (CNVs) of hsa-miR-93, hsa-miR-122, hsa-miR-192 in CAD patients with or without T2DM. +other 31392905 hsa-mir-93 Coronary Artery Disease The aim of this study was the evaluation of copy number variations (CNVs) of hsa-miR-93, hsa-miR-122, hsa-miR-192 in CAD patients with or without T2DM. +other 31392905 hsa-mir-192 Diabetes Mellitus, Type 2 The aim of this study was the evaluation of copy number variations (CNVs) of hsa-miR-93, hsa-miR-122, hsa-miR-192 in CAD patients with or without T2DM. +other 31392905 hsa-mir-93 Diabetes Mellitus, Type 2 The aim of this study was the evaluation of copy number variations (CNVs) of hsa-miR-93, hsa-miR-122, hsa-miR-192 in CAD patients with or without T2DM. +other 31392905 hsa-mir-192 Coronary Artery Disease The aim of this study was the evaluation of copy number variations (CNVs) of hsa-miR-93, hsa-miR-122, hsa-miR-192 in CAD patients with or without T2DM. +other 31392905 hsa-mir-122 Diabetes Mellitus, Type 2 The aim of this study was the evaluation of copy number variations (CNVs) of hsa-miR-93, hsa-miR-122, hsa-miR-192 in CAD patients with or without T2DM. +lncRNA target 31392505 hsa-mir-4458 Osteosarcoma Collectively, the results of rescue experiments suggested that the oncogenic role of KCNQ1OT1 was performed through sponging miR-4458 and upregulating CCND2 during osteosarcoma development, providing a novel perspective of intervention in osteosarcoma management. +lncRNA target 31391849 hsa-mir-423 Somatotroph Adenomas PTTG1 and SYT1 were the target mRNAs of miR +lncRNA target 31391772 hsa-mir-205 Pancreatic Carcinoma Proliferation experiments showed that miR-205 could promote cell proliferation in pancreatic cancer by targeting APC. +other 31391719 hsa-mir-636 Diabetic Nephropathies Overall, caffeic acid down regulates miR-636 expression level which is involved in development of diabetic nephropathy and might therefore be potential attractive therapeutic agent to pursue in DN. +transcription factor target 31391475 hsa-mir-140 Cardiomegaly In summary, in a small-range functional screen, miR3p evolved as a possible new target for the attenuation of afterload-induced pathological cardiac hypertrophy. +other 31391475 hsa-mir-140 Cardiovascular Diseases LNA-anti-miR against miR3p, a microRNA recently identified as a prognostic biomarker of cardiovascular disease, also attenuated the AE-effect. +lncRNA target 31391457 hsa-mir-215 Diabetic Nephropathies Furthermore, through microarray we found IL22RA1 was increased in glaucoma and both of miR-760 and miR +lncRNA target 31391457 hsa-mir-760 Diabetic Nephropathies Furthermore, through microarray we found IL22RA1 was increased in glaucoma and both of miR-760 and miR +lncRNA target 31391356 hsa-mir-383 Diabetic Retinopathy Therefore, AK077216 is downregulated in diabetic retinopathy and inhibited the apoptosis of ARPE-19 cells by downregulating miR-383. +genetics_knock down_suppress 31391080 hsa-mir-30 esophagus adenocarcinoma CONCLUSIONS: Loss of miR +transcription factor target 31391072 hsa-mir-671 Breast Neoplasms 5p serves as a tumor suppressor by targeting Forkhead box protein M1 (FOXM1)-mediated epithelial-to-mesenchymal transition (EMT) in BC. +genetics_overexpression_suppress 31390999 hsa-mir-193a Myocardial Reperfusion Injury CONCLUSION: Lnc-NEAT1 is overexpressed in myocardial I/R injury cells compared to normal myocardial cells, and downregulation of lnc-NEAT1 enhances cell proliferation while inhibits cell apoptosis through targeting miR-193a in I/R injury H9c2 cells. +other 31390932 hsa-mir-4784 Uterine Cervical Neoplasms Finally, LINCO1133/miR-4784 aggravated the malignant growth and aggressiveness and EMT of cervical cancer in an AHDC1-dependant way. +genetics_overexpression_promote 31390869 hsa-mir-326 Leukemia, Myeloid, Acute Moreover, overexpression of miR-326 suppressed proliferation but promoted apoptosis and PMA-induced differentiation by targeting c-Myc in AML cells. +transcription factor target 31390652 hsa-mir-199a Halal syndrome CONCLUSION: Thus, our findings suggest that miR199a-5p is a potential target for attenuating HALI pathophysiology in the developing lung. +transcription factor target 31390527 hsa-mir-10a Breast Neoplasms Our study revealed the mechanism of S-equol against breast cancer, and miR-10a-5p may be a potential target for the treatment of breast cancer. +other 31390270 hsa-mir-200a Enterocolitis, Necrotizing In addition, miR-200a-3p was also possibly involved in the molecular mechanism of CNEC, presenting deeper insights into NEC diagnosis and treatment. +epigenetics 31390052 hsa-mir-124-2 Uterine Cervical Neoplasms These results indicate that a negative FAM19A4/miR124-2 methylation assay result is likely to rule out the presence of cervical cancer. +other 31389890 hsa-mir-493 Osteosarcoma Among the markers with the highest differential expression (edgeR and DESeq algorithms), Hsa-mIR 656-3p, hsa-miR 493-5p, and hsa-miR 381-3p were upregulated in patients with pathologic fractures, whereas hsa-miR 363, hsa-miR 885-5p, and has-miR 20b-5p were downregulated. +other 31389890 hsa-mir-363 Osteosarcoma Among the markers with the highest differential expression (edgeR and DESeq algorithms), Hsa-mIR 656-3p, hsa-miR 493-5p, and hsa-miR 381-3p were upregulated in patients with pathologic fractures, whereas hsa-miR 363, hsa-miR 885-5p, and has-miR 20b-5p were downregulated. +other 31389890 hsa-mir-656 Osteosarcoma Among the markers with the highest differential expression (edgeR and DESeq algorithms), Hsa-mIR 656-3p, hsa-miR 493-5p, and hsa-miR 381-3p were upregulated in patients with pathologic fractures, whereas hsa-miR 363, hsa-miR 885-5p, and has-miR 20b-5p were downregulated. +other 31389890 hsa-mir-20b Osteosarcoma Among the markers with the highest differential expression (edgeR and DESeq algorithms), Hsa-mIR 656-3p, hsa-miR 493-5p, and hsa-miR 381-3p were upregulated in patients with pathologic fractures, whereas hsa-miR 363, hsa-miR 885-5p, and has-miR 20b-5p were downregulated. +other 31389890 hsa-mir-381 Osteosarcoma Among the markers with the highest differential expression (edgeR and DESeq algorithms), Hsa-mIR 656-3p, hsa-miR 493-5p, and hsa-miR 381-3p were upregulated in patients with pathologic fractures, whereas hsa-miR 363, hsa-miR 885-5p, and has-miR 20b-5p were downregulated. +other 31389890 hsa-mir-885 Osteosarcoma Among the markers with the highest differential expression (edgeR and DESeq algorithms), Hsa-mIR 656-3p, hsa-miR 493-5p, and hsa-miR 381-3p were upregulated in patients with pathologic fractures, whereas hsa-miR 363, hsa-miR 885-5p, and has-miR 20b-5p were downregulated. +other 31389734 hsa-mir-26a Asthma Our results shown that miR-26a, miR-133, and miR-221 were upregulated in ASM from horses with asthma exacerbation compared with asthma remission and controls. +other 31389734 hsa-mir-26a Disease Progression Our results shown that miR-26a, miR-133, and miR-221 were upregulated in ASM from horses with asthma exacerbation compared with asthma remission and controls. +other 31389734 hsa-mir-133 Asthma Our results shown that miR-26a, miR-133, and miR-221 were upregulated in ASM from horses with asthma exacerbation compared with asthma remission and controls. +other 31389734 hsa-mir-133 spondyloepimetaphyseal dysplasia, Strudwick type Our results shown that miR-26a, miR-133, and miR-221 were upregulated in ASM from horses with asthma exacerbation compared with asthma remission and controls. +other 31389734 hsa-mir-133 Disease Progression Our results shown that miR-26a, miR-133, and miR-221 were upregulated in ASM from horses with asthma exacerbation compared with asthma remission and controls. +other 31389734 hsa-mir-26a spondyloepimetaphyseal dysplasia, Strudwick type Our results shown that miR-26a, miR-133, and miR-221 were upregulated in ASM from horses with asthma exacerbation compared with asthma remission and controls. +lncRNA target 31389734 hsa-mir-221 Asthma Targeting miR-221 network genes may represent a novel approach for the treatment of ASM remodeling in asthma. +lncRNA target 31389734 hsa-mir-221 spondyloepimetaphyseal dysplasia, Strudwick type Targeting miR-221 network genes may represent a novel approach for the treatment of ASM remodeling in asthma. +other 31389734 hsa-mir-221 Disease Progression Our results shown that miR-26a, miR-133, and miR-221 were upregulated in ASM from horses with asthma exacerbation compared with asthma remission and controls. +genetics_overexpression_promote 31389670 hsa-mir-608 Prostatic Neoplasms Intracellular miR-608 overexpression inhibited in vivo PCa tumor growth, and suppressed PCa cell proliferation, G2/M transition, and migration in vitro, which was independent of EMT-associated mechanisms. +genetics_GWAS 31389668 hsa-mir-23a Diabetes Mellitus, Type 2 METHODS: A total of 784 subjects with T2DM and 846 nondiabetic subjects were enrolled and 12 single nucleotide polymorphisms (SNPs) in miRNAs (rs10459194 in miR-135a-2, rs10993081 and rs7045890 in let-7d, rs2296616 in miR-107, rs2402959 and rs6965643 in miR-96, rs24168 in miR-29a, rs3745453 in miR-23a, rs4636297 in miR-126, rs8089787 and rs9948906 in miR-133a-1 and rs999885 in miR-106b) involved in the GLUT4 pathway were genotyped using the MassArray method in a Chinese population. The genotypes of rs3745453 in miR-23a showed the difference between T2DM and control groups (p < .001). +lncRNA target 31389660 hsa-mir-204 Esophageal Neoplasms Silenced HOTAIR or elevated miR-204 inhibited proliferation, migration and invasion, along with stimulated apoptosis of oesophageal cancer cells. +other 31389608 hsa-mir-130b Carcinoma, Non-Small-Cell Lung CONCLUSIONS: CASC19 sponges miRNA-130b-3p to regulate ZBR2 as a ceRNA, thus accelerating the progression of NSCLC by regulating proliferative, migratory, and invasive capacities of tumor cells. +lncRNA target 31389605 hsa-mir-29a Leukemia, Myeloid, Acute and the expression level of miR-29a-3p in AML patients was prominently lower than that in normal controls. CONCLUSIONS: LncRNA-H19 targets miR-29a-3p to promote the proliferation of AML cells, but inhibit the apoptosis through the Wnt/ beta-catenin signaling pathway. +genetics_overexpression_promote 31389603 hsa-mir-9 Ovarian Neoplasms PATIENTS AND METHODS: The human ovarian cancer cells were cultured and miR-9 was repressed by inhibitors and overexpressed by miRNA mimics. +transcription factor target 31389598 hsa-mir-451 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: LKB1/AMPK can be involved in the cell metabolism of NSCLC and miR-451 is negatively correlated with LKB1/AMPK. Therefore, miR-451 may inhibit cell proliferation and migration of NSCLC via regulating LKB1/AMPK. +lncRNA target 31389597 hsa-mir-216a Carcinoma, Non-Small-Cell Lung In addition, lncRNA HOXA-AS2 is found to be able to promote the malignant progression of NSCLC via regulating microRNA-216a-5p. +other 31389593 hsa-mir-126 Arteriosclerosis Obliterans CONCLUSIONS: In rats with lower limb arteriosclerosis obliterans (ASO), miR-126 represses the PI3K/Akt signaling pathway to accelerate endothelial cell apoptosis. +genetics_overexpression_promote 31389592 hsa-mir-210 Arteriosclerosis Obliterans PATIENTS AND METHODS: In the present work, the vascular endothelial cells in ASO patients were selected as objects of study, the cell lines with miR-210 interference and overexpression were constructed with the Crisp/Case9 technique for subsequent experiments as experimental group, and the aortic endothelial cells of a healthy human were used as control group. +lncRNA target 31389582 hsa-mir-21 Fibrosis, Renal Silenced miR-21 probably suppresses RIF via the ERK1/2 signaling pathway. +genetics_overexpression_promote 31389580 hsa-mir-21 Arthritis, Rheumatoid MATERIALS AND METHODS: A total of 30 rats were divided into three groups: control group (healthy rats, n=10), model group (rat model of RA, n=10), and MiR group (rat model of RA injected with miR-21 lentivirus, n=10). CONCLUSIONS: MiR-21 overexpression can repress the expressions of IL-6 and IL-8 and relieve the symptoms of RA by down-regulating the Wnt signal. +other 31389579 hsa-mir-27a Osteoarthritis CONCLUSIONS: MiR-27a in OA cartilage tissues is evidently lower than in normal cartilage tissues. +circulation_biomarker_diagnosis_ns 31389577 hsa-mir-27a Osteoporosis RESULTS: The serum level of miRNA-27a-3p remained lower in osteoporosis patients relative to controls. +other 31389574 hsa-mir-122 Femur Head Necrosis 3p in BMSCs may be correlated with the progression of SONFH. +other 31389572 hsa-mir-543 Spinal Cord Injuries 5p group was higher than that of the SCI group within 1 month. +other 31389569 hsa-mir-21 Diabetic Retinopathy OBJECTIVE: To explore the effects of miR-21 on the rats with proliferative diabetic retinopathy by regulating the transforming growth factor-beta (TGF-beta) signaling pathway. CONCLUSIONS: We found that miR-21 regulates the TGF-beta signaling pathway to affect the hemodynamics in the rats with proliferative diabetic retinopathy. +lncRNA target 31389121 hsa-mir-132 Breast Neoplasms 3p suppressed the migration and invasion of breast carcinoma cells through LAPTM4B by mediating epithelial-mesenchymal transition signals, and partially reversed the carcinogenic effects of LAPTM4B by inhibiting the PI3K-AKT-mTOR signaling pathway. +lncRNA target 31389101 hsa-mir-141 Breast Neoplasms CONCLUSIONS: In conclusion, we have demonstrated that administration of miR-141 mimics at the determined doses to breast cancer cells revealed a tumor suppressor effect, and not the oncogenic face. +transcription factor target 31388332 hsa-mir-450 Carcinoma, Hepatocellular CONCLUSION: Our study demonstrated that miR5p/KIF26B/AKT axis is critical for progression of HCC, and might provide novel prognostic biomarker and therapeutic target for HCC. +transcription factor target 31388313 hsa-mir-662 Melanoma Quantitative polymerase chain reaction (qPCR) was used to examine whether miR-3662 inhibits the EMT process in the aggressive melanoma cell line, A375, through the modification of the expression of invasion-related genes in A375 cells. CONCLUSION: Down-regulation of ZEB1's expression via miR-3662 lentivirus vectors significantly decreased the in vitro and in vivo growth of the highly aggressive melanoma cell line A375. +tissue_expression_ns 31388255 hsa-mir-222 Leukemia, Myeloid, Acute Herein, we evaluated the expression of miR-181b and miR-222 in acute myeloid leukemia patients and correlation with response to therapy after hematopoietic stem cell transplantation. miR-181b gene expression was significantly increased (4.7 fold) whereas miR-222 was decreased (18.3 fold) in AML patients compared to controls (P = 0.03 and P < 0.001, respectively). Also, miR-181b and miR-222 were not differentially expressed in AML patients with M3 compared to non-M3 FAB subtypes (P > 0.05). miR-181b and miR-222 are aberrantly expressed in AML patients and their baseline level is not associated with response to treatment. +tissue_expression_ns 31388255 hsa-mir-181b Leukemia, Myeloid, Acute Herein, we evaluated the expression of miR-181b and miR-222 in acute myeloid leukemia patients and correlation with response to therapy after hematopoietic stem cell transplantation. miR-181b gene expression was significantly increased (4.7 fold) whereas miR-222 was decreased (18.3 fold) in AML patients compared to controls (P = 0.03 and P < 0.001, respectively). Also, miR-181b and miR-222 were not differentially expressed in AML patients with M3 compared to non-M3 FAB subtypes (P > 0.05). miR-181b and miR-222 are aberrantly expressed in AML patients and their baseline level is not associated with response to treatment. +exosome 31387936 hsa-mir-122 Femur Head Necrosis 5p on osteoblasts and BMSCs and effects of exosomes carrying miR +other 31387807 hsa-mir-26a Breast Neoplasms More importantly, SNHG6 and VASP both can bind directly to miR-26a, suggesting that SNHG6 could act as a ceRNA to sponge miR-26a, thereby promoting the expression of VASP, which leading to activated proliferation, migration and invasion of breast cancer cells. Taken together, this study revealed the important role of the SNHG6/miR-26a/VASP regulatory network in the development of breast cancer, and provided a reference for exploring new pathogenesis and biomarkers of breast cancer. +lncRNA target 31387451 hsa-mir-498 Esophageal Neoplasms Conclusion: This study demonstrates that inhibited UCA1 up-regulated miR-498 and down-regulated ZEB2, thereby repressing proliferation activity, invasion, migration, and EMT of EC cells. +lncRNA target 31387394 hsa-mir-186 Prostatic Neoplasms 5p via YAP1 and AMPK pathways. +genetics_overexpression_promote 31387015 hsa-mir-130a Rectal Neoplasms miR-130a was dramatically upregulated in radiosensitive rectal cancer cells and overexpression of miR-130a promotes rectal cancer cell radiosensitivity. +genetics_knock down_promote 31387005 hsa-mir-519c Carcinoma, Hepatocellular Subsequently, gain- or loss-of-function assays demonstrated that miR-519c-3p promoted HCC cell proliferation, migration as well as invasion in vitro, and facilitated the growth and metastasis of HCC cells in vivo. +genetics_overexpression_suppress 31386627 hsa-mir-618 Osteosarcoma Our research explored the role of the LINC00511/microRNA-618/MAEL axis in osteosarcoma.Expression profiles of long non-coding RNAs (lncRNAs) in osteosarcoma (OS) tissues were constructed, and LINC00511 expression levels were verified with qRT-PCR. Transfection-induced overexpression of LINC00511 and MAEL, as well as downregulation, highlighted the features of tumor cells, and LINC00511 overexpression reduced apoptosis in vitro.LINC00511 was confirmed to be beneficial for osteosarcoma development via sponging miR-618 and increasing MAEL expression and may thus be considered a potential target for osteosarcoma therapy. +exosome 31386624 hsa-mir-199a Glioma Mesenchymal stem cells delivered miR-199a to the glioma cells via the exosomes, which resulted in the suppression of the proliferation, invasion and migration of glioma cells. +circulation_biomarker_diagnosis_ns 31386584 hsa-mir-451 Pulmonary Disease, Chronic Obstructive There was a positive correlation between plasma hsa-miR-451 and caveolin-1 levels in patients with COPD/PH(+) and COPD/PH(-) (r = 0.72 and 0.63, respectively). +circulation_biomarker_diagnosis_ns 31386584 hsa-mir-451 Hypertension, Pulmonary There was a positive correlation between plasma hsa-miR-451 and caveolin-1 levels in patients with COPD/PH(+) and COPD/PH(-) (r = 0.72 and 0.63, respectively). +other 31386568 hsa-mir-489 Carcinoma, Non-Small-Cell Lung In conclusion, these data suggested that LEF1-AS1 promoted NSCLC tumorigenesis dependent on the miRSOX4 axis and implicated the potential application of LEF1-AS1 for the prognosis and treatment of NSCLC. +other 31386204 hsa-mir-210 Asthma CONCLUSION: Our data indicate that secretion of miRNAs in EVs from the airway epithelium, in particular miR-34a, miR-92b, and miR-210, might be involved in the early development of a Th2 response in the airways and asthma. +other 31386204 hsa-mir-92b Asthma CONCLUSION: Our data indicate that secretion of miRNAs in EVs from the airway epithelium, in particular miR-34a, miR-92b, and miR-210, might be involved in the early development of a Th2 response in the airways and asthma. +other 31386204 hsa-mir-34a Asthma CONCLUSION: Our data indicate that secretion of miRNAs in EVs from the airway epithelium, in particular miR-34a, miR-92b, and miR-210, might be involved in the early development of a Th2 response in the airways and asthma. +genetics_overexpression_promote 31385607 hsa-mir-140 Melanoma 5p overexpression repressed melanoma cell proliferation and invasion and its effects were partially restored SOX4 overexpression. +exosome 31385464 hsa-mir-20a Breast Neoplasms MiR-20a-5p was highly expressed in breast tumor tissues and the exosomes of MDA-MB-231 cells. The present work provides evidence that miR-20a-5p transferred from breast cancer cell-derived exosomes promotes the proliferation and differentiation of osteoclasts by targeting SRCIN1, providing scientific foundations for the development of exosome or miR-20a-5p targeted therapeutic intervention in breast cancer progression. +lncRNA target 31385350 hsa-mir-619 Infant, Small For Gestational Age By combining miRNA microarray data of the SGA placenta tissue in NCBI, it was found that two miRNAs were both hsa_circRNA15994-13 targets and differentially expressed, including hsa-miR +genetics_GWAS 31384394 hsa-mir-190b Breast Neoplasms Our results suggest that upregulation of miR-190b may occur through loss of promoter DNA methylation during the development of estrogen-receptor (ER) positive breast cancers, and that miR-190b hypo-methylation leads to increased breast cancer specific survival within the LuminalA- subtype but not LuminalB. +transcription factor target 31384392 hsa-mir-130 Endometrial Neoplasms In EC cells, the MIR130 family promoted EMT and tumor cell invasion by suppressing the expression of BHLHE40/41. We propose that BHLHE40/41 and the MIR130 family are excellent markers to predict the progression of EC cases, and that molecular therapy targeting the MIR130 family-BHLHE40/41 axis may effectively control EC extension. +genetics_overexpression_promote 31384178 hsa-mir-125b Carcinoma, Hepatocellular Moreover, dual luciferase-reporter assays revealed that miR-125b-5p targets TXNRD1 to directly regulate its expression, whereas TXNRD1 overexpression abolishes the inhibitory effect of miR-125b-5p on HCC cell proliferation, migration, and invasion. +genetics_knock down_promote 31384177 hsa-mir-122 Pancreatic Carcinoma We also verified that ALDOA was the direct target of miR-122, and the tumor suppressive effects caused by DIO3OS knockdown or miR-122 overexpression could be rescued by re-expression of ALDOA in PC cells. +circulation_biomarker_prognosis_ns 31384175 hsa-mir-25 Stomach Neoplasms Methods We applied multivariate analysis of PCA, PLS-DA and Cox Regression for clinicopathological features and survival time to explore the significance of miRNA 106b~25 expression in plasma and cancer tissues for gastric cancer. +circulation_biomarker_prognosis_ns 31384175 hsa-mir-106b Stomach Neoplasms Methods We applied multivariate analysis of PCA, PLS-DA and Cox Regression for clinicopathological features and survival time to explore the significance of miRNA 106b~25 expression in plasma and cancer tissues for gastric cancer. +lncRNA target 31384174 hsa-mir-204 Ovarian Neoplasms CONCLUSIONS: It suggests that miR-204 can be used as a tumor suppressor gene and LC3B expression level can be used as a potential molecular marker to guide the diagnosis and treatment of patients with ovarian cancer. +lncRNA target 31384173 hsa-mir-497 Carcinoma, Hepatocellular PDCD4, which was downregulated in HCC tissues, was shown to be a target of miR +lncRNA target 31384171 hsa-mir-486 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: In summary, our study sheds light on the regulatory mechanism of circFLNA in LSCC migration via sponging miR +tissue_expression_ns 31383850 hsa-mir-425 Parkinson Disease Similarly, in the brains of PD patients, miR-425 deficiency and necroptosis activation were also confirmed in dopaminergic neuron. These findings identify brain delivery of miR-425 as a potential therapeutic approach for the treatment of PD. +tissue_expression_ns 31383850 hsa-mir-425 Necrosis Similarly, in the brains of PD patients, miR-425 deficiency and necroptosis activation were also confirmed in dopaminergic neuron. These findings identify brain delivery of miR-425 as a potential therapeutic approach for the treatment of PD. +genetics_GWAS 31383788 hsa-mir-618 Breast Neoplasms Whereas, the enhanced cancer risk of miR-618 rs2682818 variant stratified by breast cancer was revealed, in heterozygote genetic model (AC vs. All in all, our meta-analysis had successfully chased down that miR-618 rs2682818 polymorphism is not linked with overall cancer risk, but in the dominant genotype of breast cancer. +lncRNA target 31383786 hsa-mir-16 Osteoarthritis Taken together, the results of our studies illuminate that SNHG1 alleviates the inflammation of IL-1beta-induced OA through the activation of miR5p-mediated p38MAPK and NF-kappaB signaling pathway. +genetics_knock down_promote 31383784 hsa-mir-93 Osteosarcoma Then, viability, invasion, and epithelial mesenchymal transition (EMT) of OS cell lines were examined when overexpressed or knocked down miR-93, or overexpressed TIMP2. +lncRNA target 31383782 hsa-mir-200a Enterocolitis, Necrotizing miR-429/200a/b and miR-141/200c clusters are poorly expressed while their target genes (VEGFA, SELE, KDR, FLT1, and HGF) are highly expressed in NEC in newborn, which might be identified as important biomarkers for this disease. +lncRNA target 31383782 hsa-mir-429 Enterocolitis, Necrotizing miR-429/200a/b and miR-141/200c clusters are poorly expressed while their target genes (VEGFA, SELE, KDR, FLT1, and HGF) are highly expressed in NEC in newborn, which might be identified as important biomarkers for this disease. +lncRNA target 31383782 hsa-mir-200b Enterocolitis, Necrotizing miR-429/200a/b and miR-141/200c clusters are poorly expressed while their target genes (VEGFA, SELE, KDR, FLT1, and HGF) are highly expressed in NEC in newborn, which might be identified as important biomarkers for this disease. +lncRNA target 31383782 hsa-mir-141 Enterocolitis, Necrotizing miR-429/200a/b and miR-141/200c clusters are poorly expressed while their target genes (VEGFA, SELE, KDR, FLT1, and HGF) are highly expressed in NEC in newborn, which might be identified as important biomarkers for this disease. +lncRNA target 31383782 hsa-mir-200c Enterocolitis, Necrotizing miR-429/200a/b and miR-141/200c clusters are poorly expressed while their target genes (VEGFA, SELE, KDR, FLT1, and HGF) are highly expressed in NEC in newborn, which might be identified as important biomarkers for this disease. +circulation_biomarker_diagnosis_up 31382975 hsa-mir-424 Infertility MiR-424 was then detected in the seminal plasma of infertile patients with high DFI(DNA Fragmentation Index); this miRNA was down-regulated but Ddx3x was upregulated in the infertile group. +transcription factor target 31382975 hsa-mir-424 Infertility, Male MiR-424 downregulation in infertile men may induce spermatogenic cell apoptosis and sperm DNA damage by directly acting on the target gene locus Ddx3x, resulting in male infertility. +genetics_overexpression_promote 31382461 hsa-mir-29 Medulloblastoma Our studies show that B7-H3 expression levels play a crucial role in promoting MB angiogenesis which can be inhibited by miR-29 overexpression via miR +other 31382190 hsa-mir-149 Osteoporosis This study provided cellular and molecular insights into the observation that miR3p was a prospective candidate gene for BMSC-based bone tissue engineering in treating osteoporosis. +transcription factor target 31382166 hsa-mir-214 Inflammatory Bowel Diseases Mechanistically, we demonstrated that limonin improved the prognosis of UC mainly through downregulating p-STAT3/miR-214 levels. +other 31382062 hsa-mir-199a Brain Ischemia CONCLUSIONS: miR-199a-5p may protect against cerebral ischemic injury by down-regulating DDR1 in rats. +genetics_overexpression_promote 31381886 hsa-mir-144 Adenocarcinoma of Lung HOXA10 was down-regulated in response to the overexpression of miR-144, whereas inhibition of LINC00466 decreased its binding to miR-144, thereby up-regulating miR-144, which, in turn, halted the lung adenocarcinoma progression. +other 31381507 hsa-mir-203 Carcinoma, Ovarian Epithelial In vitro experiments revealed that circ-ABCB10 was upregulated and promoted cell proliferation but reduced cell apoptosis, and negatively regulated miR-1271, miR-1252 and miR-203 in EOC cells. CONCLUSIONS: Circ-ABCB10 correlates with advanced clinicopathological features and unfavorable survival, and promotes proliferation, reduces apoptosis and negatively regulated miR-1271, miR-1252 and miR-203 in EOC. +lncRNA target 31381269 hsa-mir-133a Glioma A number of assays were used to detect cell proliferation, migration, invasion, cell cycle, apoptosis, glioma growth, and the targeting site between CTGF and miR-133a. +lncRNA target 31381191 hsa-mir-20b Neuralgia In CCI rat model, miR-20b-5p level was declined and Akt3 mRNA level was upregulated. This research illustrated that miR-20b-5p alleviated neuropathic pain through the inhibition of Akt3 expression in CCI rat model. +lncRNA target 31381176 hsa-mir-198 Carcinoma, Non-Small-Cell Lung 5p may be developed as a new diagnostic biomarker and therapeutic target for lung cancer. +other 31380594 hsa-mir-375 Encephalocele Finally, Exo (miR-375) were embedded with hydrogel and applied to a rat model of calvarial defect, and mu-CT analysis and histological examination were conducted to evaluate the therapeutic effects of Exo (miR-375) in bone regeneration. After incorporated with hydrogel, Exo (miR-375) displayed a slow and controlled release, and further in vivo analysis demonstrated that Exo (miR-375) enhanced the bone regenerative capacity in a rat model of calvarial defect. +lncRNA target 31380269 hsa-mir-212 Hypertrophy We aimed to investigate whether miR-212 and its selected hypertrophy-associated targets play a role in the development of RIHD. The cardiac transcript level of other selected hypertrophy-associated targets of miR-212 including extracellular signal-regulated kinase 2 (ERK2), myocyte enhancer factor 2a (MEF2a), AMP-activated protein kinase, (AMPK), heat shock protein 40 (HSP40), sirtuin 1, (SIRT1), calcineurin A-alpha and phosphatase and tensin homolog (PTEN) were also measured at week 19. +lncRNA target 31380269 hsa-mir-212 Hypertension MicroRNA-212 (miR-212) is a crucial regulator of pathologic LVH via FOXO3-mediated pathways in pressure-overload-induced heart failure. +lncRNA target 31380269 hsa-mir-212 Heart Failure MicroRNA-212 (miR-212) is a crucial regulator of pathologic LVH via FOXO3-mediated pathways in pressure-overload-induced heart failure. As a central regulator of pathologic remodeling, miR-212 might become a novel target for RIHD-induced LVH and heart failure. +other 31380150 hsa-mir-424 esophagus adenocarcinoma RESULT: In general, in the training set, six miRNAs (hsa-mir-425, hsa-let-7b, hsa-mir-23a, hsa-mir-3074, hsa-mir-424 and hsa-mir-505) displayed good prognostic power as markers of overall survival for EAC patients. +other 31380150 hsa-mir-505 esophagus adenocarcinoma RESULT: In general, in the training set, six miRNAs (hsa-mir-425, hsa-let-7b, hsa-mir-23a, hsa-mir-3074, hsa-mir-424 and hsa-mir-505) displayed good prognostic power as markers of overall survival for EAC patients. +other 31380150 hsa-mir-425 esophagus adenocarcinoma RESULT: In general, in the training set, six miRNAs (hsa-mir-425, hsa-let-7b, hsa-mir-23a, hsa-mir-3074, hsa-mir-424 and hsa-mir-505) displayed good prognostic power as markers of overall survival for EAC patients. +other 31380150 hsa-mir-23a esophagus adenocarcinoma RESULT: In general, in the training set, six miRNAs (hsa-mir-425, hsa-let-7b, hsa-mir-23a, hsa-mir-3074, hsa-mir-424 and hsa-mir-505) displayed good prognostic power as markers of overall survival for EAC patients. +other 31380150 hsa-let-7b esophagus adenocarcinoma RESULT: In general, in the training set, six miRNAs (hsa-mir-425, hsa-let-7b, hsa-mir-23a, hsa-mir-3074, hsa-mir-424 and hsa-mir-505) displayed good prognostic power as markers of overall survival for EAC patients. +other 31380150 hsa-mir-3074 esophagus adenocarcinoma RESULT: In general, in the training set, six miRNAs (hsa-mir-425, hsa-let-7b, hsa-mir-23a, hsa-mir-3074, hsa-mir-424 and hsa-mir-505) displayed good prognostic power as markers of overall survival for EAC patients. +other 31379603 hsa-mir-15b Altitude Sickness 3p and miR-15b-5p can be used as non-invasive biomarkers for predicting AMS- individuals pre-exposed to high altitude. +other 31379603 hsa-mir-134 Altitude Sickness 3p and miR-15b-5p can be used as non-invasive biomarkers for predicting AMS- individuals pre-exposed to high altitude. +genetics_GWAS 31379233 hsa-mir-125b beta-Thalassemia In this study, we identified the higher miR-125b expression in CD14 marker-positive monocytic cells of beta-thal patients. From these findings, our future studies will be to prove the hypothesis that miR-125b expression in activated monocytes may be a genetic modifier related to the severity of anemia in beta-thal patients. +genetics_GWAS 31379233 hsa-mir-125b Anemia In this study, we identified the higher miR-125b expression in CD14 marker-positive monocytic cells of beta-thal patients. From these findings, our future studies will be to prove the hypothesis that miR-125b expression in activated monocytes may be a genetic modifier related to the severity of anemia in beta-thal patients. +other 31379227 hsa-mir-16 Lung Neoplasms CONCLUSIONS: Decreased miR-16 expression may play a role in upregulating expression of MEK1 and promoting proliferation and invasion of lung cancer cells. +genetics_knock down_suppress 31379208 hsa-mir-671 Osteosarcoma 5p inhibitor significantly reversed the effects of DLEU1 knockdown on osteosarcoma cell proliferation and invasion while restoration of DDX5 rescued the proliferation and invasion of osteosarcoma cells transfected with miR +lncRNA target 31379206 hsa-mir-638 Squamous Cell Carcinoma of Head and Neck MiR-638 could inhibit wnt/beta-catenin pathway through targeting PLD1, thus realizing its anti-tumour action in OSCC. +lncRNA target 31379200 hsa-mir-629 Adenocarcinoma of Lung 3p could downregulate SFTPC expression by directly binding to the SFTPC 3'-UTR and inhibit the regulatory effect of SFTPC on lung adenocarcinoma cell proliferation. +circulation_biomarker_diagnosis_up 31379181 hsa-mir-206 Coronary Artery Disease OBJECTIVES: The aim of this study was to evaluate the possible association of miR-206 serum as an indicator of diagnosis in patients with coronary artery disease. RESULTS: The results showed a positive correlation between miR-206 expression and coronary artery disease.While the average expression of 1 /- 0.18 in the control sample was increased to 8.76 according to the severity of involvement in the patient, the relative expression of miR-206 in the CAD group was significantly increased compared to the control (p < 0. +exosome 31378912 hsa-mir-24 Myocardial Infarction, Acute Injection of hypoxic preconditioning BMSCs-exosomes markedly upregulated microRNA-24 level, reduced infarct size and improved cardiac function in AMI rats. CONCLUSIONS: Hypoxic preconditioning BMSCs-exosomes inhibit cardiomyocyte apoptosis in AMI rats by upregulating microRNA-24. +lncRNA target 31378911 hsa-mir-489 Myocardial Reperfusion Injury CONCLUSIONS: MicroRNA-489 inhibits the proliferation and accelerates apoptosis of cardiomyocytes after MIRI by targeting inhibition of SPIN1 via inactivating PI3K/AKT pathway. MicroRNA-489 may be a potential therapeutic target for MIRI. +lncRNA target 31378908 hsa-mir-124 Cerebral Infarction Furthermore, miR-124 is expected to be a target drug for the clinical treatment of CI. +other 31378905 hsa-mir-216 Fibrosis, Renal OBJECTIVE: The aim of this study was to elucidate the role of microRNA-216a in microvesicles (MVs) during the process of renal interstitial fibrosis and to investigate its underlying mechanism. CONCLUSIONS: MVs containing microRNA-216a secreted by injured proximal tubular epithelial cells participate in renal interstitial fibrosis by activating the PTEN/AKT pathway. +other 31378905 hsa-mir-216a Fibrosis, Renal OBJECTIVE: The aim of this study was to elucidate the role of microRNA-216a in microvesicles (MVs) during the process of renal interstitial fibrosis and to investigate its underlying mechanism. CONCLUSIONS: MVs containing microRNA-216a secreted by injured proximal tubular epithelial cells participate in renal interstitial fibrosis by activating the PTEN/AKT pathway. +lncRNA target 31378903 hsa-mir-92a Glioma CONCLUSIONS: MiR-92a promoted the proliferation through the KLF4/AKT/mTOR signal pathway in glioma. +other 31378901 hsa-mir-653 Glioma Further researches are required to explore the potential function and mechanism of miR-3653 in glioma. +lncRNA target 31378900 hsa-mir-381 Breast Neoplasms Moreover, miRNA-381 was newly confirmed as a direct target of SNHG7 and it mediated the suppressing effects of SNHG7 on breast cancer cells. CONCLUSIONS: SNHG7 was significantly upregulated in breast cancer and acted as an oncogene to promote breast cancer cell proliferation and invasion by directly sponging miRNA-381. +lncRNA target 31378899 hsa-mir-155 Thyroid Cancer, Papillary CONCLUSIONS: Sevoflurane inhibited migration and invasion, while enhanced cell apoptosis by downregulating miR-155 in PTC cells, suggesting important clinical implications for anesthetic agents to prevent the metastasis in PTC. +lncRNA target 31378898 hsa-mir-548c Thyroid Cancer, Papillary Moreover, miR-548c-3p mimics suppressed PTC cell viability, colony formation, cell migration, and invasion capacity. +genetics_knock down_suppress 31378893 hsa-mir-152 Lung Neoplasms Rescue experiments showed that the knockdown of microRNA-152 reversed the regulatory effects of HAGLROS on proliferative and migratory abilities of LCa cells. +genetics_knock down_promote 31378890 hsa-mir-196a Squamous Cell Carcinoma of Head and Neck FEZF1-AS1 knockdown and miR-196a over-expression models were established using lentivirus transfection in OSCC cell lines (CAL-27 and Tca8113). +lncRNA target 31378889 hsa-mir-148 Esophageal Squamous Cell Carcinoma MAP3K9 was a target gene of miR-148a and its expression was mediated by miR-148a through directly binding to the 3'-untranslated region (3'-UTR) of its mRNA in the esophagus squamous cell carcinoma. +lncRNA target 31378889 hsa-mir-148a Esophageal Squamous Cell Carcinoma MAP3K9 was a target gene of miR-148a and its expression was mediated by miR-148a through directly binding to the 3'-untranslated region (3'-UTR) of its mRNA in the esophagus squamous cell carcinoma. +genetics_overexpression_promote 31378888 hsa-mir-195 Stomach Neoplasms CONCLUSIONS: The overexpression of miR +genetics_overexpression_promote 31378886 hsa-mir-9 Colorectal Neoplasms And the overexpression of FOXP2 weakened the suppressive effect of miR +genetics_overexpression_promote 31378885 hsa-mir-6089 Carcinoma, Hepatocellular The overexpression of LIX1L partially reversed the regulatory effect of miRNA-6089 on the proliferative rate and cell cycle progression of HCC. +lncRNA target 31378877 hsa-mir-449b Osteoporosis CONCLUSIONS: microRNA-449b-5p could aggravate osteoporosis by inhibiting osteogenic differentiation of BMSCs through targeting Satb2. +circulation_biomarker_diagnosis_ns 31378876 hsa-mir-126 Diabetic Retinopathy OBJECTIVE: To study the expression and significance of micro ribonucleic acid (miR)-126 and vascular endothelial growth factor (VEGF) in the vitreous body and proliferative membrane tissues of affected eyes and plasma in proliferative diabetic retinopathy (PDR). +lncRNA target 31378455 hsa-mir-377 Glioma MiR-377 mimics and MEG3 were tumor suppressors in glioma cells through regulating PTEN expression. +other 31378131 hsa-mir-142 Carcinoma, Renal Cell 3p expression is correlated with poor prognosis of renal cell carcinoma patients and may serve as a prognostic biomarker in the future. +lncRNA target 31378128 hsa-mir-766 Lung Neoplasms 5p/KLK12 axis, indicating that CASC15 is a potential therapeutic in lung cancer. +other 31377863 hsa-mir-20a Deglutition Disorders Alterations in oropharyngeal dimensions on magnetic resonance imaging (MRI), along with heightened levels of stress, pain, and changes in stress-dependent microRNA expression (e.g., miR-320a) have been also associated with WAD, suggesting multi-factorial issues may underpin any potential swallowing changes. +other 31377861 hsa-mir-122 Carcinoma, Hepatocellular The method was successfully applied to the quantitation of microRNA-122 in hepatocellular carcinoma cell lysates. +transcription factor target 31377589 hsa-mir-15b Aortic Valve Insufficiency In addition, bortezomib ameliorated AR by suppressing Tfh cell proliferation and differentiation through miR-15b/IRF4 axis in vitro and in vivo. +lncRNA target 31377313 hsa-mir-143 Mouth Neoplasms Firstly, expression levels of miR-143, K-Ras, MMP9 and C-Myc were evaluated in OSCC tissues. Hence, microRNA-143 can be a new diagnostic biomarker and new therapeutic target for OSCC. +genetics_overexpression_promote 31376943 hsa-mir-150 Neuralgia These suppressant impacts of miR-150 on neuropathic pain process can be reversed by the overexpression of AKT3. +genetics_knock down_promote 31376654 hsa-mir-485 Carcinoma, Hepatocellular Finally, in vivo experiments were conducted to validate that knockdown of LINC00460 repressed HCC development through modulating miR +lncRNA target 31376622 hsa-mir-221 Carcinoma, Hepatocellular Here, we investigated whether myrothecine A could inhibit cell proliferation in hepatocellular carcinoma (HCC) cell line SMMC-7721 by regulating miR-221. +other 31376385 hsa-mir-34c Wounds and Injuries We found that both microRNA (miR)-34a and miR-34c were upregulated in the wound-edge epidermal keratinocytes of venous ulcers compared with normal wounds or the skin. +other 31376385 hsa-mir-34a Wounds and Injuries LGR4 axis was shown to regulate keratinocyte inflammatory response, the deregulation of which may play a pathological role in venous ulcers. +other 31376385 hsa-mir-34 Wounds and Injuries LGR4 axis was shown to regulate keratinocyte inflammatory response, the deregulation of which may play a pathological role in venous ulcers. +other 31376329 hsa-mir-200c Breast Neoplasms Expression level of miR-200c was reduced, while miR-30c expression level was enhanced in mammospheres, similar to the breast tumor tissues isolated from three patients with grade II/III who received neo-adjuvant treatment. +lncRNA target 31376096 hsa-mir-140 Cerebral Hemorrhage 5p suppresses TLR4 expression and inhibits the downstream MyD88/TRIF inflammatory pathway and NF-kappaB activity following ICH, suggesting that the inhibition of TLR4-mediated neuroinflammation at least in part accounts for the neuroprotective role of miR +lncRNA target 31376096 hsa-mir-140 Brain Injuries 5p suppresses TLR4 expression and inhibits the downstream MyD88/TRIF inflammatory pathway and NF-kappaB activity following ICH, suggesting that the inhibition of TLR4-mediated neuroinflammation at least in part accounts for the neuroprotective role of miR +lncRNA target 31376096 hsa-mir-140 Parkinson Disease 5p suppresses TLR4 expression and inhibits the downstream MyD88/TRIF inflammatory pathway and NF-kappaB activity following ICH, suggesting that the inhibition of TLR4-mediated neuroinflammation at least in part accounts for the neuroprotective role of miR +transcription factor target 31375553 hsa-mir-21 Breast Neoplasms CONCLUSION: MiR-21 promotes the proliferation, migration and invasion and inhibits the apoptosis of breast cancer cells by inhibiting MAPK10. +transcription factor target 31375213 hsa-mir-424 Alzheimer Disease MiR5p may thus serve as a protective target for AD and provide a new strategy for the prevention and treatment of AD. +exosome 31374207 hsa-mir-106b Pancreatic Carcinoma MiR-106b was directly transferred from CAFs to pancreatic cancer cells through exosomes. Summarily, our data demonstrated that CAFs-derived exosomal miR-106b plays a vital role in causing GEM resistance of pancreatic cancer, thus offering a new target for sensitizing pancreatic cancer cells to GEM. +lncRNA target 31374070 hsa-let-7g Nasopharyngeal Carcinoma RESULTS Let-7g-5p was under-expressed in human NPC cells. CONCLUSIONS Let-7g-5p is lowly expressed in NPC and it was the first to discover that IGF-1R was a target gene of let-7g-5p in NPC. +other 31374052 hsa-mir-125a hereditary diffuse gastric cancer Furthermore, favorable OS was also found in lung cancer (HR = 0.343, 95% CI: 0.228-0.517, P < .001) and gastric cancer (HR = 0.341, 95% CI: 0.160-0.725, P = .005) patients with high miR-125a-5p expression. Besides, high miR-125a-5p expression was correlated with early stage (OR = 0.413, 95% CI: 0.228-0.749, P = .004) and negative lymph node metastasis (OR = 0.262, 95% CI: 0.073-0.941, P = .04) in gastric cancer, and was linked with better tumor differentiation in pan-cancer (OR = 1.623, 95% CI: 1.064-2.476, P = .025) and lung cancer (OR = 2.371, 95% CI: 1.358-4.141, P = .002). +other 31374052 hsa-mir-125a Lung Neoplasms Furthermore, favorable OS was also found in lung cancer (HR = 0.343, 95% CI: 0.228-0.517, P < .001) and gastric cancer (HR = 0.341, 95% CI: 0.160-0.725, P = .005) patients with high miR-125a-5p expression. Besides, high miR-125a-5p expression was correlated with early stage (OR = 0.413, 95% CI: 0.228-0.749, P = .004) and negative lymph node metastasis (OR = 0.262, 95% CI: 0.073-0.941, P = .04) in gastric cancer, and was linked with better tumor differentiation in pan-cancer (OR = 1.623, 95% CI: 1.064-2.476, P = .025) and lung cancer (OR = 2.371, 95% CI: 1.358-4.141, P = .002). +circulation_biomarker_diagnosis_up 31373926 hsa-mir-125b Small-Bowel Neuroendocrine Tumor RESULTS Four serum miRNAs (miR-125b-5p, +circulation_biomarker_diagnosis_up 31373926 hsa-mir-362 Small-Bowel Neuroendocrine Tumor Serum miR-125b-5p and miR +lncRNA target 31373842 hsa-mir-934 Urinary Bladder Neoplasms Inhibition of UBE2N-dependent CDK6 protein degradation by miR-934 promotes human bladder cancer cell growth. +genetics_overexpression_suppress 31373834 hsa-let-7 Perinatal Death Here, we showed that Lin28A overexpression prevents normal lung development via the inhibition of the Let-7 micro RNAs, thus causing the perinatal lethality. +genetics_overexpression_suppress 31373834 hsa-let-7 Death Here, we showed that Lin28A overexpression prevents normal lung development via the inhibition of the Let-7 micro RNAs, thus causing the perinatal lethality. +transcription factor target 31373336 hsa-mir-214 Hypertension, Pulmonary CONCLUSIONS In conclusion, these results indicate that miR3p acts as a novel regulator of hypoxia-induced proliferation and migration by directly targeting ARHGEF12 and dysregulating c-jun and c-fos in PASMCs, and may be a potential therapeutic target for treating pulmonary hypertension. +genetics_knock down_promote 31373336 hsa-mir-214 Hypoxia 3p significantly attenuated hypoxia-induced proliferation and migration in PASMCs and promoted apoptosis, whereas this effect was aggravated by overexpression of miR +circulation_biomarker_diagnosis_ns 31373075 hsa-mir-122 Carcinoma, Hepatocellular By the terminal time point of the study, in addition to elevated levels of serum miR-182, serum miR5p was also found to be increased (>1.5-fold) in animals that developed hepatocarcinomas. +circulation_biomarker_diagnosis_ns 31373075 hsa-mir-182 Carcinoma, Hepatocellular By the terminal time point of the study, in addition to elevated levels of serum miR-182, serum miR5p was also found to be increased (>1.5-fold) in animals that developed hepatocarcinomas. +lncRNA target 31372832 hsa-mir-375 Breast Neoplasms 3p (miR-375) has been suggested to serve as a tumor suppressor or oncogene in various tumor types; however, its specific expression and potential regulatory role in malignant breast cancer remain unclear. +other 31372667 hsa-mir-29b Hypoxia Release of exo-miRNAs hsa-miR-29b-3p and hsa-miR-216a-5p was detected within 6 h of exposure to cytokines and hypoxia. +other 31372667 hsa-mir-216a Hypoxia Release of exo-miRNAs hsa-miR-29b-3p and hsa-miR-216a-5p was detected within 6 h of exposure to cytokines and hypoxia. +other 31372241 hsa-mir-103 Carcinoma, Hepatocellular Mechanistic studies found that circRNA_101505 could sensitize HCC cells to cisplatin by sponging miR-103, and thereby promoting oxidored-nitro domain-containing protein 1 (NOR1) expression. +lncRNA target 31372165 hsa-mir-101 Colorectal Neoplasms Furthermore, the suppressive effects of miR-101 on the autophagy, proliferation, and apoptosis of CRC were abolished by Malat1. CONCLUSION: Long non-coding RNA Malat1 activated autophagy and promoted cell proliferation, yet inhibited apoptosis by sponging miR-101 in colorectal cancer cells. +other 31372109 hsa-mir-499 Polymyositis These results suggest that myomiRs, especially miR-1, miR-133a, miR-208b, miR-486, and miR-499 function in a network, and are associated with the development of PM. +other 31372109 hsa-mir-208b Polymyositis These results suggest that myomiRs, especially miR-1, miR-133a, miR-208b, miR-486, and miR-499 function in a network, and are associated with the development of PM. +other 31372109 hsa-mir-1 Polymyositis These results suggest that myomiRs, especially miR-1, miR-133a, miR-208b, miR-486, and miR-499 function in a network, and are associated with the development of PM. +other 31372109 hsa-mir-486 Polymyositis These results suggest that myomiRs, especially miR-1, miR-133a, miR-208b, miR-486, and miR-499 function in a network, and are associated with the development of PM. +other 31372109 hsa-mir-133a Polymyositis These results suggest that myomiRs, especially miR-1, miR-133a, miR-208b, miR-486, and miR-499 function in a network, and are associated with the development of PM. +lncRNA target 31372094 hsa-mir-24 Thyroid Cancer, Papillary CONCLUSIONS: In conclusion, the findings suggest that lncRNA-MIAT may promote PTC proliferation and invasion through physically binding miR +lncRNA target 31372052 hsa-mir-218 Uterine Cervical Neoplasms Conclusion: Our data revealed microRNA-218 enhanced the cisplatin sensitivity in cervical cancer cells through regulation of cell growth and cell apoptosis, which could potentially benefit to the cervical cancer treatment in the future. +circRNA target 31372051 hsa-mir-187 Colorectal Neoplasms Conclusion: Circ-ITGA7 might suppress CRC proliferation by sponging miR3p and increasing ASXL1 expression. +other 31371997 hsa-mir-21 Colonic Neoplasms Furthermore, for the first time, we suggested that miR-21 can be a good molecular marker for classification of the stages of colon cancer. +lncRNA target 31371987 hsa-mir-34a Prostatic Neoplasms Conclusion: The DANCR/miR-34a-5p axis enhanced DTX resistance of PC via targeting JAG1, providing a novel insight to improve chemotherapy for PC. +genetics_GWAS 31371743 hsa-mir-6127 Colorectal Neoplasms 5p could be a potential epigenetic mechanism induced by RAPA therapy in the regulation of the pre-metastatic niche of post-transplant colorectal cancer. +genetics_GWAS 31371743 hsa-mir-6746 Colorectal Neoplasms 5p could be a potential epigenetic mechanism induced by RAPA therapy in the regulation of the pre-metastatic niche of post-transplant colorectal cancer. +genetics_GWAS 31371743 hsa-mir-6787 Colorectal Neoplasms 5p could be a potential epigenetic mechanism induced by RAPA therapy in the regulation of the pre-metastatic niche of post-transplant colorectal cancer. +circRNA target 31371702 hsa-mir-1256 Stomach Neoplasms The circHECTD1/miR-1256/USP5 axis could thus be used as a therapeutic target for GC. +other 31371699 hsa-mir-27a Acquired Immunodeficiency Syndrome Here we show that HIVinfected macrophages and HIV-1 proteins Tat or gp120-treated macrophages express high levels of microRNAs, including miR-23a and miR-27a. +genetics_overexpression_promote 31371307 hsa-mir-138 Melanoma Overexpression of miRNA-138 or inhibition of HIF1alpha significantly suppressed the growth and metastasis of melanoma in vivo Our study demonstrates the role and clinical relevance of miRNA-138 and HIF1alpha in melanoma cell growth and metastasis, providing a novel therapeutic target for suppression of melanoma growth and metastasis. +lncRNA target 31369989 hsa-mir-338 Squamous Cell Carcinoma of Head and Neck 3p/NRP1 axis and suggest OIP5-AS1 as a potential therapy target for OSCC. +genetics_overexpression_promote 31369289 hsa-mir-136 Gallbladder Neoplasms Together, our results indicated that overexpressed miR-136 attenuates angiogenesis and enhances cell apoptosis in GBC via the JNK signaling pathway by downregulating the expression of MAP2K4.NEW & NOTEWORTHY This study is based on previous studies suggesting the tumor-suppressive role of microRNA (miR)-136 in various cancers. +lncRNA target 31369209 hsa-mir-1 Hypoxia-Ischemia, Brain All together, telmisartan cardioprotected against the myocardial damage through the microRNA-1 modulation, and consequent modifications of its downstream target connexin 43, potassium voltage-gated channel subfamily Q member 1 and Bcl-2. +lncRNA target 31369196 hsa-mir-145 Esophageal Neoplasms Here, we aimed to investigate the possible function of lncRNA PVT1 in esophageal carcinoma (EC) via targeting of microRNA-145 (miR-145). +other 31368817 hsa-mir-203 Breast Neoplasms miR-203 was highly expressed in 22 pair of breast cancer tissues than the matched paracancerous tissues. +circulation_biomarker_diagnosis_up 31368668 hsa-mir-130a Diabetes Mellitus, Type 2 CONCLUSION: Circulating miR-130 may regulate the expression of PPAR-gamma and can be used as a biomarker to discriminate DM2-CAD from CAD. +circulation_biomarker_diagnosis_up 31368668 hsa-mir-130a Coronary Artery Disease CONCLUSION: Circulating miR-130 may regulate the expression of PPAR-gamma and can be used as a biomarker to discriminate DM2-CAD from CAD. +circulation_biomarker_diagnosis_ns 31368531 hsa-mir-21 Hepatitis C Thus miRNA-21 could be used as promising serum biomarker, for assessment of antiviral treatment efficacy and improvement of fibrosis among chronically infected HCV patients. +lncRNA target 31368498 hsa-mir-380 Arene Oxide Detoxification Defect Previously, we have investigated the effects of nuclear factor erythroid 2 related factor 2 (Nrf2) and microRNAs in PQ-induced neurotoxicity, addressing the function of miR3p, a microRNA dysregulated by PQ, as well as Nrf2 deficiency. +lncRNA target 31368365 hsa-mir-377 Carcinoma, Hepatocellular This study revealed that circVAPA contributes to HCC cell proliferation through sponging miR3p and thereby disinhibiting PSAP, shedding light on a new insight into HCC initiation and progression. +circulation_biomarker_prognosis_ns 31368064 hsa-mir-145 familial temporal lobe epilepsy 3 The aim of this study was to analyze the expression profiles of the microRNAs (miRNAs) miR-145, miR-181c, miR-199a and miR-1183 in the hippocampus and blood of patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) and to investigate whether these can be used as diagnosis and prognosis biomarkers for epilepsy. +circulation_biomarker_prognosis_ns 31368064 hsa-mir-1183 familial temporal lobe epilepsy 3 The aim of this study was to analyze the expression profiles of the microRNAs (miRNAs) miR-145, miR-181c, miR-199a and miR-1183 in the hippocampus and blood of patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) and to investigate whether these can be used as diagnosis and prognosis biomarkers for epilepsy. +circulation_biomarker_prognosis_ns 31368064 hsa-mir-181c familial temporal lobe epilepsy 3 The aim of this study was to analyze the expression profiles of the microRNAs (miRNAs) miR-145, miR-181c, miR-199a and miR-1183 in the hippocampus and blood of patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) and to investigate whether these can be used as diagnosis and prognosis biomarkers for epilepsy. +circulation_biomarker_prognosis_ns 31368064 hsa-mir-199a familial temporal lobe epilepsy 3 The aim of this study was to analyze the expression profiles of the microRNAs (miRNAs) miR-145, miR-181c, miR-199a and miR-1183 in the hippocampus and blood of patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) and to investigate whether these can be used as diagnosis and prognosis biomarkers for epilepsy. +other 31368060 hsa-mir-20a Stomach Neoplasms OBJECTIVE(S): In this study, we aimed to investigate the effect of docosahexaenoic acid (DHA) and docetaxel alone or in combination on the expression level of MICA and its regulating microRNA (miRNA), miR-20a in MKN45 GC cell line. +lncRNA target 31367490 hsa-mir-137 Squamous Cell Carcinoma of Head and Neck Of these RNAs, lncRNAs (TSPEAR-AS, CASK-AS1, MIR137HG, PART1, LSAMP-AS1), miRNA (has-mir-210) and mRNAs (HOXC13, STC2, DIO1, FOXD4L1) had a significant effect on the prognosis of LSCC. Furthermore, five lncRNAs (TSPEAR-AS, CASK-AS1, MIR137HG, PART1, LSAMP-AS1) were identified as potential prognostic biomarkers and therapeutic targets for LSCC. +transcription factor target 31367191 hsa-mir-214 Breast Neoplasms CONCLUSIONS: This study reveals a possible role of miRNAmediated Taxol resistance, contributing to identify novel therapeutic targets against chemoresistant breast cancers. +lncRNA target 31367007 hsa-mir-216b Pancreatic Carcinoma Our data does not support a tumor suppressor role for miR-216a, miR-216b or miR-217 in PDAC and emphasizes the need for phenotypic evaluation of miRNAs in complex in vivo models beyond that performed using cell culture. +lncRNA target 31367007 hsa-mir-216a Pancreatic Carcinoma Our data does not support a tumor suppressor role for miR-216a, miR-216b or miR-217 in PDAC and emphasizes the need for phenotypic evaluation of miRNAs in complex in vivo models beyond that performed using cell culture. +lncRNA target 31367007 hsa-mir-217 Pancreatic Carcinoma Our data does not support a tumor suppressor role for miR-216a, miR-216b or miR-217 in PDAC and emphasizes the need for phenotypic evaluation of miRNAs in complex in vivo models beyond that performed using cell culture. +lncRNA target 31366735 hsa-mir-122 Hepatitis B A major hepatocyte-specific microRNA, miRNA-122, was found to be positively correlated with ADAR1 expression, and exogenous miRNA-122 decreased both HBV RNA and DNA, whereas, conversely, transfection with a miRNA-122 inhibitor increased them. This study demonstrated, for the first time, that ADAR1 plays an antiviral role against HBV infection by increasing the level of miRNA-122 in hepatocytes. +lncRNA target 31366567 hsa-mir-7 Myocardial Reperfusion Injury 5p/PARP1 pathway, which might provide a new therapeutic target for treatment of myocardial I/R injury. +other 31366492 hsa-mir-145 Skin Neoplasms 3p as markers of aggressiveness in melanoma. +other 31366492 hsa-mir-203 Skin Neoplasms 3p as markers of aggressiveness in melanoma. +other 31366492 hsa-mir-211 Skin Neoplasms 5p expression levels were analyzed in primary cutaneous melanomas, including thin and thick melanomas, and in melanoma metastases by quantitative Real-Time PCR. +other 31366492 hsa-mir-205 Skin Neoplasms 5p expression levels were analyzed in primary cutaneous melanomas, including thin and thick melanomas, and in melanoma metastases by quantitative Real-Time PCR. +genetics_overexpression_promote 31366242 hsa-mir-15a Osteoarthritis, Knee Overexpression of SMAD2 reversed the inhibitory effects on proliferation and promotion effects on apoptosis induced by miR-15a in knee arthritis chondrocytes. +other 31365884 hsa-mir-25 Vascular Diseases 5p) may be involved in the pathogenesis and processes of vascular diseases. +genetics_knock down_promote 31365693 hsa-mir-383 Stomach Neoplasms HDAC9 knockout or miR +genetics_overexpression_promote 31364752 hsa-mir-501 Colorectal Neoplasms In the current study, it was demonstrated that miR5013p was overexpressed in colorectal tumor tissues compared to the adjacent normal tissues. +lncRNA target 31364749 hsa-mir-126 Triple Negative Breast Neoplasms Collectively, the present study revealed that miR1263p plays a role as a tumor suppressor in regulating TNBC cell activities by targeting RGS3, indicating that the miR1263p/RGS3 axis may be a potential treatment target. +genetics_overexpression_promote 31364737 hsa-mir-124 Liver Neoplasms Overexpression of miR124 reduced CLIC1 expression at both the protein and mRNA levels in liver cancer cells. +circulation_biomarker_diagnosis_ns 31364733 hsa-mir-15b Urinary Bladder Neoplasms miR15b5p and miR5905p were finally confirmed to discriminate between cancer cases and controls; however, for disease monitoring of BC, both miRNAs were not suitable as a decline in the miRNA levels was not observed in some patients after tumor removal. Our results suggested that circulating miR15b5p and miR5905p have useful diagnostic potential for BC, but are rather unsuitable as monitoring markers for disease. +circulation_biomarker_diagnosis_ns 31364733 hsa-mir-590 Urinary Bladder Neoplasms miR15b5p and miR5905p were finally confirmed to discriminate between cancer cases and controls; however, for disease monitoring of BC, both miRNAs were not suitable as a decline in the miRNA levels was not observed in some patients after tumor removal. Our results suggested that circulating miR15b5p and miR5905p have useful diagnostic potential for BC, but are rather unsuitable as monitoring markers for disease. +genetics_overexpression_promote 31364725 hsa-mir-29a Osteosarcoma Overexpression using miR29a mimics decreased DNMT3B expression and the methylation level of SOCS1, which resulted in the upregulation of SOCS1 in U2OS and MG63 cells, while miR29a inhibition led to the opposite results. +lncRNA target 31364134 hsa-mir-181a Myocardial Reperfusion Injury OBJECTIVE: The aim of this study was to explore the influence of the micro ribonucleic acid (miR)-181a on myocardial ischemia-reperfusion injury (MIRI) in rats by regulating the protein kinase B (Akt) signaling pathway. CONCLUSIONS: MiR-181a activates Akt to promote the phosphorylation of its downstream protein eNOS, inhibit the apoptosis of myocardial cells, and alleviate MIRI. +transcription factor target 31364131 hsa-mir-17 Heart Neoplasms CONCLUSIONS: We believe that targeted regulation of miR5p on TMOD1 gene affects the neuroactive ligand-receptor interaction pathway, and it promotes proliferation and apoptosis of cardia cancer cells. +lncRNA target 31364127 hsa-mir-29c Diabetes Mellitus Besides, miR-29c silencing may inhibit the DN renal fibrosis through AMPK/mTOR signals, so miR-29c may be an effective target for the treatment of DN renal fibrosis. +lncRNA target 31364127 hsa-mir-29c Fibrosis, Renal Besides, miR-29c silencing may inhibit the DN renal fibrosis through AMPK/mTOR signals, so miR-29c may be an effective target for the treatment of DN renal fibrosis. +lncRNA target 31364126 hsa-mir-191 Glioblastoma We also found that miR-191 directly targeted NDST1 and negatively regulated the NDST1 expression in human glioblastoma cells. +lncRNA target 31364125 hsa-mir-29a Laryngeal Neoplasms CONCLUSIONS: NEAT1 is a novel oncogene in laryngocarcinoma and could enhance growth and invasion of laryngocarcinoma cells by targeting miR-29a-3p. +genetics_knock down_promote 31364120 hsa-mir-378 Squamous Cell Carcinoma of Head and Neck MicroRNA-378 knockdown significantly decreased proliferative, invasive, and metastatic abilities of OSCC cells. +lncRNA target 31364116 hsa-mir-105 Stomach Neoplasms RESULTS: MiR-105 was downregulated in gastric cancer tissues and cells; it suppressed gastric cancer cell migration, invasion and epithelial-mesenchymal transition (EMT) in gastric cancer. +lncRNA target 31364115 hsa-mir-28 Stomach Neoplasms Down-regulation of miR-328 inhibits the proliferation, invasion and migration of gastric cancer cell lines. +genetics_overexpression_promote 31364113 hsa-mir-155 Colorectal Neoplasms MicroRNA-155 overexpression upregulated E-cadherin and downregulated vimentin in CRC cells. +genetics_overexpression_suppress 31364112 hsa-mir-511 Colorectal Neoplasms It was also observed that overexpression of miR +other 31364111 hsa-mir-577 Colorectal Neoplasms The modulating associations between DUXAP8 and miR-577 and RAB14 were further studied in CRC cells. +genetics_knock down_promote 31364107 hsa-mir-8073 Ovarian Neoplasms Meanwhile, the recovery experiment revealed that overexpression of ZnT1 can counteract the effect of microRNA-8073 mimics on OC cell proliferation and apoptosis so as to affect the malignant progression of OC. +genetics_overexpression_promote 31364106 hsa-mir-1236 Osteosarcoma The overexpression of miRNA +other 31364104 hsa-mir-15b Diabetes Mellitus OBJECTIVE: To investigate the role of microRNA-15b in diabetic retinopathy and its underlying mechanism. CONCLUSIONS: Low expression of microRNA-15b in retinal capillary endothelial cells and pericytes of diabetic rats promotes the development of diabetic retinopathy by up-regulating VEGFA. +lncRNA target 31364003 hsa-mir-1261 Glioma Biological behaviors of glioma cells were detected, circ-PTPRZ1 enhanced cell proliferation and invasion, and inhibited cell apoptosis; miR-1261 had the opposite effects, and could terminate the above effects of circ-PTPRZ1. +genetics_overexpression_promote 31363382 hsa-mir-466 Carcinoma, Hepatocellular In addition, ROCK2 overexpression partially reversed the inhibitory effect of microRNA-466 overexpression on HCC cell migration and invasion. +circulation_biomarker_diagnosis_up 31363381 hsa-mir-372 Inflammatory Bowel Diseases In conclusion, high levels of miR-372 detected in peripheral blood samples may serve a role as a potential biomarker to screen potential patients with UC from healthy controls. +other 31363375 hsa-mir-140 Carcinoma, Non-Small-Cell Lung 5p expression was significantly downregulated in NSCLC tissues compared with matched normal tissues. +lncRNA target 31363368 hsa-mir-26a Pancreatitis Rosiglitazone pretreatment prevented AP progression through suppression of miR-26a expression via binding to and degrading PTEN. +lncRNA target 31363080 hsa-mir-142 Adenocarcinoma of Lung 5p/CDK5 regulatory axis may serve as a novel therapeutic target in the treatment of LUAD. +transcription factor target 31362998 hsa-mir-191 Sepsis 5p mimic could observably inhibit renal injury scores, and inhibit inflammatory cytokine productions and apoptotic protein levels in septic rats. +transcription factor target 31362998 hsa-mir-191 Acute Kidney Injury 5p mimic could observably inhibit renal injury scores, and inhibit inflammatory cytokine productions and apoptotic protein levels in septic rats. +lncRNA target 31362245 hsa-mir-140 Hyperglycemia Finally, we showed that H19 exerted its function via the modulation of H19/miR-140/HE4 in hyperglycemia with alpha-Mangostin. +circulation_biomarker_diagnosis_ns 31361816 hsa-mir-122 Acute Liver Injury AIMS: In acute alcoholic liver injury, alcohol can directly or indirectly induce endoplasmic reticulum stress (ERS) to participate in liver injury, and it is found that the expression of serum exosomal miR-122 is significantly affected. CONCLUSIONS: These findings suggest that ER stress inhibitor PBA attenuated ethanol induced acute liver injury and serum exosomal miR-122, and provides a potential therapy strategy for acute alcoholic liver injury. +other 31361168 hsa-mir-146a Rhinitis, Allergic miR-146a mimic markedly attenuated sneezing and nasal rubbing events, decreased the levels of ovalbumin-specific IgE as well as mastocyte- and basophil-related inflammatory cytokines, reduced inflammatory cells, affected the T-helper 2-released cytokines. +lncRNA target 31360737 hsa-mir-125b Breast Neoplasms mediated activity on VEGF promoter function and inhibited cancer cell migration and invasion potentials in vitro. +circulation_biomarker_diagnosis_up 31360199 hsa-mir-451a Arthritis, Gouty 3p and downregulate IL-1beta in the plasma, while etoricoxib may treat AGA by upregulating miR-451a and downregulating COX-2. +circulation_biomarker_diagnosis_up 31360199 hsa-mir-223 Arthritis, Gouty 3p and downregulate IL-1beta in the plasma, while etoricoxib may treat AGA by upregulating miR-451a and downregulating COX-2. +genetics_overexpression_suppress 31360191 hsa-mir-509 Thyroid Cancer, Papillary 5p was overexpressed in PTC cells and tissues in which SFRP1 was down-regulated. +genetics_overexpression_promote 31360121 hsa-mir-28 Nasopharyngeal Neoplasms Overexpression of miR +other 31360113 hsa-mir-29c Carcinoma, Non-Small-Cell Lung Based on the logistic regression model, a 4-miRNAs set (miR-146b, miR-205, miR-29c and miR-30b) was picked out of the 5 miRNAs owing to its excellent diagnostic power for NSCLC patients in the training set (AUC=0.99, accuracy=95.00%), the testing set (AUC=0.93, accuracy=89.69%), and the training-testing combined set ( AUC=0.96, accuracy=92.00%). +other 31360113 hsa-mir-146b Carcinoma, Non-Small-Cell Lung Based on the logistic regression model, a 4-miRNAs set (miR-146b, miR-205, miR-29c and miR-30b) was picked out of the 5 miRNAs owing to its excellent diagnostic power for NSCLC patients in the training set (AUC=0.99, accuracy=95.00%), the testing set (AUC=0.93, accuracy=89.69%), and the training-testing combined set ( AUC=0.96, accuracy=92.00%). +other 31360113 hsa-mir-205 Carcinoma, Non-Small-Cell Lung Based on the logistic regression model, a 4-miRNAs set (miR-146b, miR-205, miR-29c and miR-30b) was picked out of the 5 miRNAs owing to its excellent diagnostic power for NSCLC patients in the training set (AUC=0.99, accuracy=95.00%), the testing set (AUC=0.93, accuracy=89.69%), and the training-testing combined set ( AUC=0.96, accuracy=92.00%). +lncRNA target 31360102 hsa-mir-424 Cholangiocarcinoma 5p is found to be a suppressor of ARK5, by binding to 3'-UTR of ARK5 mRNA and then inhibiting mTOR phosphorylated, thus deregulating epithelial-mesenchymal transition (EMT) of ICC. +circulation_biomarker_diagnosis_ns 31359371 hsa-mir-92a Mycobacterium avium-intracellulare Infection CONCLUSION: Circulating miR-92a-3p, miR +circulation_biomarker_diagnosis_ns 31359371 hsa-mir-423 Mycobacterium avium-intracellulare Infection CONCLUSION: Circulating miR-92a-3p, miR +circulation_biomarker_diagnosis_ns 31359371 hsa-mir-652 Mycobacterium avium-intracellulare Infection CONCLUSION: Circulating miR-92a-3p, miR +circulation_biomarker_diagnosis_ns 31359371 hsa-mir-423 Chondrocalcinosis CONCLUSION: Circulating miR-92a-3p, miR +circulation_biomarker_diagnosis_ns 31359371 hsa-mir-652 Chondrocalcinosis CONCLUSION: Circulating miR-92a-3p, miR +circulation_biomarker_diagnosis_ns 31359371 hsa-mir-126 Chondrocalcinosis CONCLUSION: Circulating miR-92a-3p, miR +other 31359371 hsa-mir-106a Mycobacterium avium-intracellulare Infection 5p high expression correlated with shorter MACCE-free survival. +circulation_biomarker_diagnosis_ns 31359371 hsa-mir-126 Mycobacterium avium-intracellulare Infection CONCLUSION: Circulating miR-92a-3p, miR +circulation_biomarker_diagnosis_ns 31359371 hsa-mir-92a Chondrocalcinosis CONCLUSION: Circulating miR-92a-3p, miR +other 31359311 hsa-mir-126 Skin Diseases Results were validated by quantitative real-time PCR in 30 exposed subjects from each of the groups, which showed that among others miR-21, miR-23a, miR-27a, miR-122, miR-124, miR-126, miR-619, and miR-3613 were significantly upregulated and miR-1282 and miR-4530 were downregulated in the skin lesion group compared with the no skin lesion group. +other 31359311 hsa-mir-122 Skin Diseases Results were validated by quantitative real-time PCR in 30 exposed subjects from each of the groups, which showed that among others miR-21, miR-23a, miR-27a, miR-122, miR-124, miR-126, miR-619, and miR-3613 were significantly upregulated and miR-1282 and miR-4530 were downregulated in the skin lesion group compared with the no skin lesion group. +other 31359311 hsa-mir-613 Skin Diseases Results were validated by quantitative real-time PCR in 30 exposed subjects from each of the groups, which showed that among others miR-21, miR-23a, miR-27a, miR-122, miR-124, miR-126, miR-619, and miR-3613 were significantly upregulated and miR-1282 and miR-4530 were downregulated in the skin lesion group compared with the no skin lesion group. +other 31359311 hsa-mir-4530 Skin Diseases Results were validated by quantitative real-time PCR in 30 exposed subjects from each of the groups, which showed that among others miR-21, miR-23a, miR-27a, miR-122, miR-124, miR-126, miR-619, and miR-3613 were significantly upregulated and miR-1282 and miR-4530 were downregulated in the skin lesion group compared with the no skin lesion group. +other 31359311 hsa-mir-124 Skin Diseases Results were validated by quantitative real-time PCR in 30 exposed subjects from each of the groups, which showed that among others miR-21, miR-23a, miR-27a, miR-122, miR-124, miR-126, miR-619, and miR-3613 were significantly upregulated and miR-1282 and miR-4530 were downregulated in the skin lesion group compared with the no skin lesion group. +other 31359311 hsa-mir-1282 Skin Diseases Results were validated by quantitative real-time PCR in 30 exposed subjects from each of the groups, which showed that among others miR-21, miR-23a, miR-27a, miR-122, miR-124, miR-126, miR-619, and miR-3613 were significantly upregulated and miR-1282 and miR-4530 were downregulated in the skin lesion group compared with the no skin lesion group. +other 31359311 hsa-mir-21 Skin Diseases Results were validated by quantitative real-time PCR in 30 exposed subjects from each of the groups, which showed that among others miR-21, miR-23a, miR-27a, miR-122, miR-124, miR-126, miR-619, and miR-3613 were significantly upregulated and miR-1282 and miR-4530 were downregulated in the skin lesion group compared with the no skin lesion group. +other 31359311 hsa-mir-27a Skin Diseases Results were validated by quantitative real-time PCR in 30 exposed subjects from each of the groups, which showed that among others miR-21, miR-23a, miR-27a, miR-122, miR-124, miR-126, miR-619, and miR-3613 were significantly upregulated and miR-1282 and miR-4530 were downregulated in the skin lesion group compared with the no skin lesion group. +other 31359311 hsa-mir-619 Skin Diseases Results were validated by quantitative real-time PCR in 30 exposed subjects from each of the groups, which showed that among others miR-21, miR-23a, miR-27a, miR-122, miR-124, miR-126, miR-619, and miR-3613 were significantly upregulated and miR-1282 and miR-4530 were downregulated in the skin lesion group compared with the no skin lesion group. +other 31359035 hsa-mir-181a Ovarian Diseases Importantly, increased miR-181a expression and decreased S1PR1 expression were detected in the in vivo ovarian oxidative stress model by Western blot analysis and immunohistochemistry. +other 31359035 hsa-mir-181a Primary Ovarian Insufficiency Furthermore, we found similar expression patterns of miR-181a and S1PR1 in GCs from patients with premature ovarian insufficiency. +exosome 31358876 hsa-mir-21 Diabetic Nephropathies Differential Expression of Urinary Exosomal MicroRNAs miR +exosome 31358689 hsa-mir-216a Inflammation Thus, our results reveal a novel role of miR-216a-5p-containing exosomes in endothelial cells, implying a potential therapeutic target for inflammation in syphilis patients. +circulation_biomarker_diagnosis_ns 31358689 hsa-mir-216a Syphilis Our study first identified dramatically decreased miR-216a-5p in plasma of syphilis patients compared with the healthy control, which was negatively correlated with the expression of inflammatory cytokines, including IL-1beta, IL-6, and TNF-alpha. +genetics_overexpression_promote 31357957 hsa-mir-1275 Stomach Neoplasms miR-1275 supresses migration and invasion of GC cells in vitro and in vivo, which was restored by JAZF1 overexpression. +lncRNA target 31357838 hsa-mir-144 Neuroblastoma Conclusion: MiR-144 inhibits proliferation, promotes apoptosis and enhances the sensitivity of neuroblastoma cells to DDP through targeting MYCN, which provides a potential treatment for neuroblastoma. +lncRNA target 31357837 hsa-mir-126 Stomach Neoplasms Conclusion: miR-126 suppresses the proliferation and invasion of gastric cancer cells through targeting the 3'-UTR of IGF-1R and inhibiting its expression. +other 31357021 hsa-mir-125a Glioma Particularly, MIR4435-2HG is highly expressed in high-grade glioma and may have an impact on EMT and TNFalpha signaling pathway by functioning as a miRNA sponge of miR-125a-5p and miR-125b-5p to increase the expression of CD44. +other 31357021 hsa-mir-4435-2 Glioma Particularly, MIR4435-2HG is highly expressed in high-grade glioma and may have an impact on EMT and TNFalpha signaling pathway by functioning as a miRNA sponge of miR-125a-5p and miR-125b-5p to increase the expression of CD44. +other 31357021 hsa-mir-125b Glioma Particularly, MIR4435-2HG is highly expressed in high-grade glioma and may have an impact on EMT and TNFalpha signaling pathway by functioning as a miRNA sponge of miR-125a-5p and miR-125b-5p to increase the expression of CD44. +lncRNA target 31356563 hsa-mir-1271 Multiple Myeloma This study identified dysregulation of lncRNA urothelial carcinoma associated 1 (UCA1) and hepatocyte growth factor (HGF) mRNA via the Gene Expression Omnibus (GEO) database, which was traced to the mutual target miRNA, miR +transcription factor target 31356112 hsa-mir-146a Diabetic Nephropathies Furthermore, TGFB1 may be involved in DN progression through the regulation of miR +transcription factor target 31356112 hsa-mir-21 Diabetic Nephropathies Furthermore, TGFB1 may be involved in DN progression through the regulation of miR +other 31355988 hsa-mir-100 Mouth Neoplasms CONCLUSION: Our results indicate that hsa-mir-99b-3p and hsa-mir5p may serve as novel prognostic biomarkers in OSCC. +other 31355988 hsa-mir-100 Squamous Cell Carcinoma of Head and Neck CONCLUSION: Our results indicate that hsa-mir-99b-3p and hsa-mir5p may serve as novel prognostic biomarkers in OSCC. +other 31355988 hsa-mir-99b Mouth Neoplasms CONCLUSION: Our results indicate that hsa-mir-99b-3p and hsa-mir5p may serve as novel prognostic biomarkers in OSCC. +other 31355988 hsa-mir-99b Squamous Cell Carcinoma of Head and Neck CONCLUSION: Our results indicate that hsa-mir-99b-3p and hsa-mir5p may serve as novel prognostic biomarkers in OSCC. +circulation_biomarker_diagnosis_ns 31355469 hsa-mir-34a Diabetes Mellitus, Type 2 Circulating miR-375, miR-34a, and miR-146a were not associated with beta-cell functionality, but their expression was differentially affected by glycaemia, obesity, insulin treatment, and the presence of nephropathy and diabetic foot. +circulation_biomarker_diagnosis_ns 31355469 hsa-mir-375 Diabetes Mellitus, Type 2 Circulating miR-375, miR-34a, and miR-146a were not associated with beta-cell functionality, but their expression was differentially affected by glycaemia, obesity, insulin treatment, and the presence of nephropathy and diabetic foot. +circulation_biomarker_diagnosis_ns 31355469 hsa-mir-146a Diabetes Mellitus, Type 2 The relative expression of miR-146a in pre-diabetic individuals, T2D patients with insulin treatment, and T2D patients with nephropathy and diabetic foot was decreased. Circulating miR-375, miR-34a, and miR-146a were not associated with beta-cell functionality, but their expression was differentially affected by glycaemia, obesity, insulin treatment, and the presence of nephropathy and diabetic foot. +lncRNA target 31355416 hsa-mir-16 Thyroid Cancer, Papillary In addition, rescue assays further confirmed that SNHG12 contributed to the progression of PTC through regulating miR +lncRNA target 31355248 hsa-mir-451 Cardiotoxicity In conclusion, miR-451 inhibition protected against Dox-induced cardiotoxicity via activation of AMPK signaling pathway. +lncRNA target 31355230 hsa-mir-195 Adenocarcinoma of Lung CONCLUSIONS: MiR-195, as a suppressor of lung adenocarcinoma, regulates CD4+ T cell activation via CCDC88C. +other 31355227 hsa-mir-19a Leukemia, Myeloid, Acute BACKGROUND: This study aimed to investigate the effects of microRNA19a (miR-19a) antisense oligonucleotide (ASODN) on the proliferation and apoptosis of acute myeloid leukemia cells (HL60). +lncRNA target 31355138 hsa-mir-153 Urinary Bladder Neoplasms At the gene level, miR-153 targeted IDO1 expression and inhibited bladder cancer cell tryptophan metabolism through inhibiting IL6/STAT3/VEGF signaling. +genetics_overexpression_promote 31354837 hsa-mir-214 Sciatic Neuropathy Finally, we demonstrated that miR-214 upon overexpression in SCLCs enhanced the therapeutic effects of SCLCs on sciatic nerve injury. +genetics_overexpression_promote 31354837 hsa-mir-214 Carcinoma, Small Cell Moreover, we discovered a novel signaling transduction pathway in SCLCs; that is, miR-214 directly targets c-Jun to promote the myelination of SCLCs. Finally, we demonstrated that miR-214 upon overexpression in SCLCs enhanced the therapeutic effects of SCLCs on sciatic nerve injury. +transcription factor target 31354796 hsa-mir-590 Atherosclerosis Collectively, these data indicated that PPAR-gamma may have the therapeutic potential in atherosclerosis via the transcriptional regulation of miR5p in endothelial cells. +lncRNA target 31354360 hsa-mir-382 Breast Neoplasms Conclusion: SNHG1 promotes breast cancer through the regulation of miR +genetics_knock down_suppress 31354344 hsa-mir-193a Colorectal Neoplasms Loss and gain-of-function studies were carried out to reveal the effects and potential mechanism of the miR-193a-3p in the proliferation, metastasis and angiogenesis of CRC cells. +lncRNA target 31354295 hsa-mir-216a Colorectal Neoplasms Conclusion: Taken together, our findings indicate that miR-216a was a tumor-suppressor miRNA in human CRC, which can inhibit autophagy via the TGF-beta/MAP1S pathway. +genetics_overexpression_promote 31354293 hsa-mir-4374 Esophageal Squamous Cell Carcinoma Further experimental results demonstrated that miR-4324 mimic remarkably downregulated epithelial-to-mesenchymal transition (EMT) phenotype, which can also be effectively prevented by overexpressing FAK in ESCC cells. +genetics_overexpression_promote 31354293 hsa-mir-4324 Esophageal Squamous Cell Carcinoma Further experimental results demonstrated that miR-4324 mimic remarkably downregulated epithelial-to-mesenchymal transition (EMT) phenotype, which can also be effectively prevented by overexpressing FAK in ESCC cells. +other 31354287 hsa-mir-16 Uterine Cervical Neoplasms Conclusion: This study indicates that KLF4 and ESR1 are downregulated by the upregulated miR21 and miRNA16 in cervical cancer, respectively, using bioinformatics analysis, and the lower expression of KLF4 and ESR1 is closely related to the poor prognosis. +other 31354287 hsa-mir-21 Uterine Cervical Neoplasms Conclusion: This study indicates that KLF4 and ESR1 are downregulated by the upregulated miR21 and miRNA16 in cervical cancer, respectively, using bioinformatics analysis, and the lower expression of KLF4 and ESR1 is closely related to the poor prognosis. +genetics_overexpression_promote 31354286 hsa-mir-124 Carcinoma, Hepatocellular Overexpression of miRNA-124 led to inhibited, while overexpression of lncRNA-UCA1 led to increased proliferation, migration and invasion rates of HCC cell lines. +other 31354246 hsa-mir-29a Osteoarthritis Results: TMF down regulated miR-29a/beta-catenin signaling activity and cleaved caspase-3 expression and up regulated Foxo3a expression in OA rat cartilages. +lncRNA target 31354069 hsa-mir-451a Endometriosis Systemic treatment with a miR-451a inhibitor is a promising therapy for endometriosis that simultaneously affects multiple pathways driving the disease. +circRNA target 31354028 hsa-mir-762 Pre-Eclampsia miR-762 expression was lower in PE placentas and played a promoting role in trophoblast cell migration and EMT. circTNRC18/miR-762/Grhl2 axis may be a potential therapeutic target in PE. +transcription factor target 31353965 hsa-mir-143 Cardiomegaly This study demonstrated the effects of atorvastatin in attenuating cardiac hypertrophy and inhibiting cardiac failure, which is depending on Bcl2 expression via miR3p inhibition by AMPK activation. +lncRNA target 31353963 hsa-mir-10a Inflammation Conclusions: Data corroboarted that AP mitigated LPS-evoked inflammatory injury through repression of NF-kappaB and JAK2/STAT3 pathways by regulating miR-10a in HT22 cells. +genetics_overexpression_promote 31353880 hsa-mir-145 Acute Lung Injury 5p overexpression alleviated lung tissue injury, decreased the expression levels of IL-1beta, IL-6 and TNF-alpha and reduced MPO activity. +other 31353396 hsa-mir-26a Carcinoma, Squamous Cell Comparisons of cancer and mature teratoma identified two markedly upregulated miRNAs (miR-151a-3p and miR-378a-3p) and two markedly downregulated miRNAs (miR-26a-5p and miR-99a-5p). +other 31353396 hsa-mir-151a Carcinoma, Squamous Cell Comparisons of cancer and mature teratoma identified two markedly upregulated miRNAs (miR-151a-3p and miR-378a-3p) and two markedly downregulated miRNAs (miR-26a-5p and miR-99a-5p). +other 31353396 hsa-mir-26a Teratoma Comparisons of cancer and mature teratoma identified two markedly upregulated miRNAs (miR-151a-3p and miR-378a-3p) and two markedly downregulated miRNAs (miR-26a-5p and miR-99a-5p). +other 31353396 hsa-mir-378a Carcinoma, Squamous Cell Comparisons of cancer and mature teratoma identified two markedly upregulated miRNAs (miR-151a-3p and miR-378a-3p) and two markedly downregulated miRNAs (miR-26a-5p and miR-99a-5p). +other 31353396 hsa-mir-378a Teratoma Comparisons of cancer and mature teratoma identified two markedly upregulated miRNAs (miR-151a-3p and miR-378a-3p) and two markedly downregulated miRNAs (miR-26a-5p and miR-99a-5p). +other 31353396 hsa-mir-99a Teratoma Comparisons of cancer and mature teratoma identified two markedly upregulated miRNAs (miR-151a-3p and miR-378a-3p) and two markedly downregulated miRNAs (miR-26a-5p and miR-99a-5p). +other 31353396 hsa-mir-99a Carcinoma, Squamous Cell Comparisons of cancer and mature teratoma identified two markedly upregulated miRNAs (miR-151a-3p and miR-378a-3p) and two markedly downregulated miRNAs (miR-26a-5p and miR-99a-5p). +other 31353396 hsa-mir-151a Teratoma Comparisons of cancer and mature teratoma identified two markedly upregulated miRNAs (miR-151a-3p and miR-378a-3p) and two markedly downregulated miRNAs (miR-26a-5p and miR-99a-5p). +genetics_knock down_suppress 31353329 hsa-mir-181a Dmd-Associated Dilated Cardiomyopathy In summary, our findings reveal that Malat1 knockdown attenuates high glucose-induced cardiomyocyte apoptosis via releasing miR-181a-5p, and this mechanism may provide us with new diagnosis target of DCM. +other 31352929 hsa-mir-382 Fibrosis, Renal Based on the developed 3D hypoxia microenvironment, we found miR-382 might play a vital role in renal fibrosis. +circulation_biomarker_prognosis_up 31352863 hsa-mir-193a Glomerulonephritis, Membranous Moreover, highly expressed miR-193a, lowly expressed WT1/PODXL, elevated amounts of proteinuria (>3.79 g/24 h)/serum creatinine (>174.63 mumol/L), and declined GFR ( C polymorphism is an independent variable and associated with a decreased risk of CRC in Chinese population. +genetics_GWAS 31349954 hsa-mir-34b Colorectal Neoplasms CONCLUSION These findings indicate that the miR-34b/c rs4938723T > C polymorphism is an independent variable and associated with a decreased risk of CRC in Chinese population. +other 31349873 hsa-mir-29b Triple Negative Breast Neoplasms METHODS: The relative miR-29b-3p expression in different breast cancer cell lines were determined by qRT-PCR. +lncRNA target 31349837 hsa-mir-34a Carcinoma, Hepatocellular On the other hand, miR-34a targets Smad4 via the TGF-beta pathway, followed by altering the transcription of the downstream genes (i.e., CTGF and IL-11) that are associated with BM. +genetics_overexpression_promote 31349748 hsa-mir-9 Squamous Cell Carcinoma of Head and Neck RECK was predicated as a novel target gene of miR-9, and overexpressed RECK hindered JAK1/STAT3 and PI3K/AKT pathways in OSCC cells. +transcription factor target 31349708 hsa-mir-142 Colonic Neoplasms AC can be a potent synergistic adjuvant, down-regulates cancer stemness genes and enhances the antitumor ability of 5-FU by stimulating apoptosis-associated genes, suppressing inflammation and metastasis genes through miR142-3p in colon cancer. +exosome 31349698 hsa-mir-29c Lupus Nephritis LN chronicity index (CI) correlated with urinary exosomal miR-21, miR-150, and miR-29c (r = 0.565, 0.840, -0.559, respectively). In conclusion, a urinary exosomal multimarker panel composed of miR-21, miR-150, and miR-29c provides a non-invasive method to detect early renal fibrosis and predict disease progression in LN. +exosome 31349698 hsa-mir-150 Fibrosis, Renal LN chronicity index (CI) correlated with urinary exosomal miR-21, miR-150, and miR-29c (r = 0.565, 0.840, -0.559, respectively). In conclusion, a urinary exosomal multimarker panel composed of miR-21, miR-150, and miR-29c provides a non-invasive method to detect early renal fibrosis and predict disease progression in LN. +exosome 31349698 hsa-mir-21 Lupus Nephritis LN chronicity index (CI) correlated with urinary exosomal miR-21, miR-150, and miR-29c (r = 0.565, 0.840, -0.559, respectively). In conclusion, a urinary exosomal multimarker panel composed of miR-21, miR-150, and miR-29c provides a non-invasive method to detect early renal fibrosis and predict disease progression in LN. +exosome 31349698 hsa-mir-21 Fibrosis, Renal LN chronicity index (CI) correlated with urinary exosomal miR-21, miR-150, and miR-29c (r = 0.565, 0.840, -0.559, respectively). In conclusion, a urinary exosomal multimarker panel composed of miR-21, miR-150, and miR-29c provides a non-invasive method to detect early renal fibrosis and predict disease progression in LN. +exosome 31349698 hsa-mir-29c Fibrosis, Renal LN chronicity index (CI) correlated with urinary exosomal miR-21, miR-150, and miR-29c (r = 0.565, 0.840, -0.559, respectively). In conclusion, a urinary exosomal multimarker panel composed of miR-21, miR-150, and miR-29c provides a non-invasive method to detect early renal fibrosis and predict disease progression in LN. +exosome 31349698 hsa-mir-150 Lupus Nephritis LN chronicity index (CI) correlated with urinary exosomal miR-21, miR-150, and miR-29c (r = 0.565, 0.840, -0.559, respectively). In conclusion, a urinary exosomal multimarker panel composed of miR-21, miR-150, and miR-29c provides a non-invasive method to detect early renal fibrosis and predict disease progression in LN. +other 31349687 hsa-mir-133b Opioid-Related Disorders Only the level of miR-133b in OUD patients on MMT was significantly lower than that in healthy controls. This study indicates that miR-133b values may be decreased in OUD patients on MMT. +other 31348817 hsa-mir-122 Chemical and Drug Induced Liver Injury Micro-RNA (miR)-122 is a promising exploratory biomarker for detecting liver injury in preclinical and clinical studies. +lncRNA target 31348766 hsa-mir-129 Laryngeal Neoplasms CONCLUSIONS Our study demonstrated that SNHG12 promoted LSCC cells progression via sponging miR +circulation_biomarker_diagnosis_down 31348521 hsa-mir-181a Myasthenia Gravis We found that miR-181a was downregulated in the peripheral blood mononuclear cells (PBMCs) of MG patients and was associated with QMGs and anti-AChR Ab levels. +circulation_biomarker_diagnosis_up 31348274 hsa-mir-520f Lung Neoplasms The cut-off value of serum miR-520f for lung cancer diagnosis was 1.815, with a sensitivity of 79.9% and a specificity of 84.2%.Serum miR-520f was down-regulated in lung cancer patients, and may be a candidate biomarker for non-invasive screening of the disease. +lncRNA target 31347720 hsa-mir-1 Glioma Rescue assays were performed and confirmed the regulatory loop FOXD2-AS1/miR-31/CDK1 in glioma. Collectively, our results indicated that the FOXD2-AS1/miR-31/CDK1 axis influenced glioma progression, providing a potential new target for glioma patients. +other 31347327 hsa-mir-200a Carcinoma, Hepatocellular CONCLUSION: LncRNA MALAT1 was involved in proliferation, migration, invasion, and apoptosis by interacting with miR-200a in hypoxic Hep3B cells, revealing a new mechanism of MALAT1 involved in hypoxic HCC progression. +circulation_biomarker_diagnosis_up 31347326 hsa-mir-381 Stomach Neoplasms AUC analysis showed that the sensitivity and specificity of serum miRNA-381 in the diagnosis of GC were superior to those of other tumor markers. +transcription factor target 31347176 hsa-mir-7 Breast Neoplasms Collectively, the findings demonstrate the miR-7 inhibits breast cancer growth via suppressing ALDH1A3 activity concomitant with decreasing BCSC subpopulation. +lncRNA target 31347173 hsa-mir-495 Myocardial Reperfusion Injury Subsequently, it was manifested that MAPK6 was a target of miR +genetics_knock down_promote 31347170 hsa-mir-18a Ovarian Neoplasms Upon overexpressing WDFY3-AS2 or inhibiting miR-18a, RORA expression was increased, thereby the OC cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition (EMT) were suppressed, accompanied by enhanced apoptosis. +transcription factor target 31347003 hsa-mir-26b Scleroderma, Systemic Moreover, we demonstrated that the hsa-miR-26b-5p inhibitor might inhibit fibrosis in TGF-beta-activated fibroblasts, which would be a promising target for SSc therapy. +circulation_biomarker_diagnosis_ns 31346930 hsa-mir-92a Obesity Further studies would be necessary to establish miR-92a as serum biomarker and potential predictor of the BS success in improving the metabolic status of patients with obesity. +transcription factor target 31346547 hsa-mir-107 Breast Neoplasms This study aims to demonstrate the function of miR-107 and its roles in chemo-drug resistance in breast cancer cells. CONCLUSIONS: miR-107 plays a role in regulating chemo-drug sensitivity in mammary cancer cell by targeting TRIAP1. +transcription factor target 31346357 hsa-mir-200c Radiation-Induced Oral Mucositis These results not only identify the key role of miR-200c in the pathogenesis of RIOM but also provide a novel therapeutic target to treat RIOM. +circRNA target 31346335 hsa-mir-103a-2 Colorectal Neoplasms Taken together, these findings suggest that hsa_circ_0007142 is upregulated in CRC and targets miR-103a +lncRNA target 31346316 hsa-mir-29 Colorectal Neoplasms CONCLUSIONS: Current evidences suggest miR-29 family may become promising biomarkers for risk, recurrence, metastasis and survival outcome of CRC. +other 31346130 hsa-mir-29b Ovarian Neoplasms CONCLUSION: Our analysis showed no differences in miR29b and 199a expression, and differences in baseline CTCs in women with newly diagnosed ovarian tumors were not statistically significant. +lncRNA target 31345231 hsa-mir-449a Diabetes Mellitus BACKGROUND: miR-449a, an intronic miRNA, is highly down-regulated in the skeletal muscle during diabetes. CONCLUSION: Our results indicate towards a critical role for miR-449a and its target, Jag1 in regulating Notch signalling and insulin signalling in the skeletal muscle and imply that targeting this axis might hold therapeutic potential for impaired skeletal muscle metabolism during diabetes. +genetics_overexpression_promote 31345147 hsa-mir-125b Parkinson Disease Subsequently, rescue experiments revealed that miR-125b induced neuron apoptosis, inhibited neurite outgrowth and promoted inflammation, also increased PTGS2 and CDK5 expressions but decreased FOXQ1 expression in lnc-MALAT1 overexpression treated AD models. CONCLUSION: Lnc-MALAT1 might interact with miR-125b to inhibit neuron apoptosis and inflammation while promote neurite outgrowth in AD. +genetics_overexpression_promote 31345147 hsa-mir-125b Alzheimer Disease Subsequently, rescue experiments revealed that miR-125b induced neuron apoptosis, inhibited neurite outgrowth and promoted inflammation, also increased PTGS2 and CDK5 expressions but decreased FOXQ1 expression in lnc-MALAT1 overexpression treated AD models. CONCLUSION: Lnc-MALAT1 might interact with miR-125b to inhibit neuron apoptosis and inflammation while promote neurite outgrowth in AD. +transcription factor target 31345144 hsa-mir-340 Cicatrix miR5p could be a therapeutic target for preventing scarring. +genetics_overexpression_promote 31344555 hsa-let-7a Liver Injury RESULTS: The overexpression of lncRNA NEAT1 accompanied by Let-7a inhibition and TLR4 activation was found in sepsis-induced liver injury patients. +genetics_overexpression_promote 31344555 hsa-let-7a Sepsis RESULTS: The overexpression of lncRNA NEAT1 accompanied by Let-7a inhibition and TLR4 activation was found in sepsis-induced liver injury patients. +circRNA target 31344361 hsa-mir-577 Nasopharyngeal Carcinoma In conclusion, circ_0008450 acts as an oncogene in NPC cells through regulating miR-577/CXCL9 signaling. +other 31344049 hsa-mir-21 Lung Neoplasms We focused our attention on Homo sapiens-microRNA21 (hsa-miR21), one of most relevant miRNA associated with lung cancer progression, metastasis and EMT. In conclusion, hsa-miR21 and TGF-beta1 are involved in autocrine and paracrine circuits that regulate the EMT status of lung cancer cells. +genetics_overexpression_suppress 31343368 hsa-mir-34a Neuroblastoma Conclusion: The expression of miR-34a was down-regulated in paediatric neuroblastoma tissues, and overexpression of miR-34a could inhibit proliferation, migration and invasion of SH-SY5Y cells by targeting HNF4alpha. +circulation_biomarker_diagnosis_ns 31342956 hsa-let-7b Ischemic Stroke Our findings suggest the potential usefulness of blood miR3p and let-7b-3p as noninvasive bio markers for the diagnosis of hyperacute ischemic stroke. +circulation_biomarker_diagnosis_ns 31342956 hsa-mir-223 Ischemic Stroke Our findings suggest the potential usefulness of blood miR3p and let-7b-3p as noninvasive bio markers for the diagnosis of hyperacute ischemic stroke. +lncRNA target 31342947 hsa-mir-423 Lung Neoplasms CONCLUSIONS The lncRNA MT1JP suppresses NSCLC biological activities by regulating the miRNA +circulation_biomarker_diagnosis_up 31342266 hsa-mir-338 Cerebral Infarction, Acute Plasma levels of hsa-miR +circulation_biomarker_diagnosis_up 31342266 hsa-mir-140 Cerebral Infarction, Acute Plasma levels of hsa-miR +circulation_biomarker_diagnosis_up 31342266 hsa-mir-483 Cerebral Infarction, Acute Plasma levels of hsa-miR +circulation_biomarker_diagnosis_up 31342266 hsa-mir-145 Cerebral Infarction, Acute Plasma levels of hsa-miR +lncRNA target 31341888 hsa-mir-195 Cardiomegaly 5p promotes cardiac hypertrophy via targeting MFN2 and FBXW7 and may provide promising therapeutic strategies for interfering cardiac hypertrophy. +transcription factor target 31341885 hsa-mir-29 Fibrosis, Renal During renal fibrosis miR-21, miR-192 and miR-433 (fibrosis promotors) are activated by transforming growth factor-beta (TGF-beta), and miR-29 and miR-200 family (fibrosis supressors) are inhibited by TGF-beta. This profile was observed by decrease of fibrosis suppresors miR-29 and miR-200 and not by increase of fibrosis promotors miR-21, miR192, and miR-433. +other 31341885 hsa-mir-21 Fabry Disease A direct correlation between urinary miR-21 and degree of albuminuria was observed. +transcription factor target 31341885 hsa-mir-200 Fabry Disease During renal fibrosis miR-21, miR-192 and miR-433 (fibrosis promotors) are activated by transforming growth factor-beta (TGF-beta), and miR-29 and miR-200 family (fibrosis supressors) are inhibited by TGF-beta. This profile was observed by decrease of fibrosis suppresors miR-29 and miR-200 and not by increase of fibrosis promotors miR-21, miR192, and miR-433. +transcription factor target 31341885 hsa-mir-433 Fabry Disease During renal fibrosis miR-21, miR-192 and miR-433 (fibrosis promotors) are activated by transforming growth factor-beta (TGF-beta), and miR-29 and miR-200 family (fibrosis supressors) are inhibited by TGF-beta. This profile was observed by decrease of fibrosis suppresors miR-29 and miR-200 and not by increase of fibrosis promotors miR-21, miR192, and miR-433. +transcription factor target 31341885 hsa-mir-200 Fibrosis, Renal During renal fibrosis miR-21, miR-192 and miR-433 (fibrosis promotors) are activated by transforming growth factor-beta (TGF-beta), and miR-29 and miR-200 family (fibrosis supressors) are inhibited by TGF-beta. This profile was observed by decrease of fibrosis suppresors miR-29 and miR-200 and not by increase of fibrosis promotors miR-21, miR192, and miR-433. +transcription factor target 31341885 hsa-mir-192 Fabry Disease During renal fibrosis miR-21, miR-192 and miR-433 (fibrosis promotors) are activated by transforming growth factor-beta (TGF-beta), and miR-29 and miR-200 family (fibrosis supressors) are inhibited by TGF-beta. This profile was observed by decrease of fibrosis suppresors miR-29 and miR-200 and not by increase of fibrosis promotors miR-21, miR192, and miR-433. +transcription factor target 31341885 hsa-mir-29 Fabry Disease During renal fibrosis miR-21, miR-192 and miR-433 (fibrosis promotors) are activated by transforming growth factor-beta (TGF-beta), and miR-29 and miR-200 family (fibrosis supressors) are inhibited by TGF-beta. This profile was observed by decrease of fibrosis suppresors miR-29 and miR-200 and not by increase of fibrosis promotors miR-21, miR192, and miR-433. +other 31341885 hsa-mir-21 Fibrosis, Renal A direct correlation between urinary miR-21 and degree of albuminuria was observed. +transcription factor target 31341885 hsa-mir-192 Fibrosis, Renal During renal fibrosis miR-21, miR-192 and miR-433 (fibrosis promotors) are activated by transforming growth factor-beta (TGF-beta), and miR-29 and miR-200 family (fibrosis supressors) are inhibited by TGF-beta. This profile was observed by decrease of fibrosis suppresors miR-29 and miR-200 and not by increase of fibrosis promotors miR-21, miR192, and miR-433. +transcription factor target 31341885 hsa-mir-433 Fibrosis, Renal During renal fibrosis miR-21, miR-192 and miR-433 (fibrosis promotors) are activated by transforming growth factor-beta (TGF-beta), and miR-29 and miR-200 family (fibrosis supressors) are inhibited by TGF-beta. This profile was observed by decrease of fibrosis suppresors miR-29 and miR-200 and not by increase of fibrosis promotors miR-21, miR192, and miR-433. +transcription factor target 31341646 hsa-mir-16 Carcinoma, Hepatocellular 3eta is involved in sorafenib resistance in HCC and that these two factors could be potential therapeutic targets and biomarkers for predicting the response to sorafenib treatment. +circulation_biomarker_diagnosis_ns 31341453 hsa-mir-182 Uterine Cervical Diseases CONCLUSION: This study suggests that serum expression of miR-21, miR-182, let-7b, miR-145, and p53 is comparable to cervical cell expression and could be useful in differentiating abnormal cervix from the healthy cervix. +circulation_biomarker_diagnosis_ns 31341453 hsa-mir-145 Uterine Cervical Diseases CONCLUSION: This study suggests that serum expression of miR-21, miR-182, let-7b, miR-145, and p53 is comparable to cervical cell expression and could be useful in differentiating abnormal cervix from the healthy cervix. +circulation_biomarker_diagnosis_ns 31341453 hsa-mir-21 Uterine Cervical Diseases CONCLUSION: This study suggests that serum expression of miR-21, miR-182, let-7b, miR-145, and p53 is comparable to cervical cell expression and could be useful in differentiating abnormal cervix from the healthy cervix. +circulation_biomarker_diagnosis_ns 31341453 hsa-let-7b Uterine Cervical Diseases CONCLUSION: This study suggests that serum expression of miR-21, miR-182, let-7b, miR-145, and p53 is comparable to cervical cell expression and could be useful in differentiating abnormal cervix from the healthy cervix. +lncRNA target 31341413 hsa-mir-539 Pseudarthrosis These findings provide evidence that miR5p should be considered as an important candidate target for the development of preventive or therapeutic approaches against bone nonunions. +genetics_knock down_promote 31341054 hsa-mir-128 Acquired Immunodeficiency Syndrome Manipulation of miR-128 levels in HIV-1 target cell lines and in primary CD4(+) T-cells by overexpression or knockdown showed that reduction of TNPO3 levels by miR-128 significantly affects HIV-1 replication but not murine leukemia virus (MLV) infection and that miR-128 modulation of HIV-1 replication is reduced with TNPO3-independent HIV-1 virus, suggesting that miR +circulation_biomarker_diagnosis_up 31341019 hsa-mir-221 Triple Negative Breast Neoplasms Moreover, elevated miR221 levels in MV derived from human TNBC patients' blood could induce cell proliferation and metastasis in recipient cells. +genetics_overexpression_promote 31340910 hsa-mir-340 Stomach Neoplasms Overexpression of miRNA-340 suppress the proliferation of GC cells, suggesting its involvement in the development of GC along with multiple circRNAs. +lncRNA target 31340767 hsa-mir-383 Carcinoma, Hepatocellular CCND1/PARP2 axis in HCC tumorigenesis, suggesting that PTTG3P may be used as a potential therapeutic target in HCC. +transcription factor target 31340754 hsa-mir-122 Carcinoma, Hepatocellular The proliferation of HCC cells and production of proinflammatory cytokines were measured with miR-122 upregulation and inhibition. +other 31340667 hsa-mir-378a Ehlers-Danlos Syndrome, musculocontractural type 1 Mechanistically, treatment with TGF-beta1 (transforming growth factor beta1) and transfection of microRNA (miR)-378a-3p mimics induced a similar metabolic reprogramming of PV-ADSCs, including upregulated mitochondrial potential and altered lipid levels, such as increased cholesterol and promoted smooth muscle differentiation. +other 31340667 hsa-mir-378a Polycythemia Vera Mechanistically, treatment with TGF-beta1 (transforming growth factor beta1) and transfection of microRNA (miR)-378a-3p mimics induced a similar metabolic reprogramming of PV-ADSCs, including upregulated mitochondrial potential and altered lipid levels, such as increased cholesterol and promoted smooth muscle differentiation. +lncRNA target 31340494 hsa-mir-29b Carcinoma, Non-Small-Cell Lung This study aimed to evaluate the anti-cancer effect of a combination therapy of miRNA-29b and genistein loaded in mucin-1 (MUC 1)-aptamer functionalized hybrid nanoparticles in non-small cell lung cancer (NSCLC) A549 cell line. Results generated were able to demonstrate that genistein-miRNA-29b-loaded hybrid nanoparticles (GMLHN) could be a potential treatment modality for NSCLC because of the ability of the payloads to attack multiple targets. +other 31340494 hsa-mir-29b Drug Hypersensitivity This study aimed to evaluate the anti-cancer effect of a combination therapy of miRNA-29b and genistein loaded in mucin-1 (MUC 1)-aptamer functionalized hybrid nanoparticles in non-small cell lung cancer (NSCLC) A549 cell line. +other 31338994 hsa-mir-146a Coronary Disease CONCLUSION: miRNA-146a is involved in the pathogenesis of both periodontitis and coronary heart disease. +other 31338994 hsa-mir-146a Chronic Periodontitis CONCLUSION: miRNA-146a is involved in the pathogenesis of both periodontitis and coronary heart disease. +other 31338984 hsa-mir-369 Chronic Inflammation In vivo, oral administration of quercetin in dextran-sulfate-sodium-induced colitis induces miR3p expression. +circulation_biomarker_diagnosis_ns 31338931 hsa-mir-26a Intervertebral Disc Degeneration In summary, we established a method that consistently profiles circulating miRNAs and identified multiple miRNAs as promising biomarkers for disc degeneration, among which miR-26a-5p enhances VEGF expression during disc degeneration through targeting Smad1 signalling. +other 31338886 hsa-mir-19b Multiple Myeloma In addition, the relationship between PTENP1, miR-19b, and TSC1, as well as the role of PTENP1 in MM, was explored. Higher levels of PTENP1 and TSC1 mesenger RNA (mRNA) were observed in the MM group, along with a lower level of miR-19b. +genetics_GWAS 31338876 hsa-mir-155 Intracranial Aneurysm CONCLUSION: The results of this study showed that the SNP rs767649 in the promoter of miR-155 could reduce the transcription activity of miR-155, while poorly expressed miR-155 could increase the incidence of IA rupture by increasing the expression of MMP-2, especially in subjects carrying the TT genotype of SNP rs767649. +genetics_GWAS 31338876 hsa-mir-155 Cerebral Hemorrhage CONCLUSION: The results of this study showed that the SNP rs767649 in the promoter of miR-155 could reduce the transcription activity of miR-155, while poorly expressed miR-155 could increase the incidence of IA rupture by increasing the expression of MMP-2, especially in subjects carrying the TT genotype of SNP rs767649. +genetics_knock down_promote 31338875 hsa-mir-214 Melanoma Overexpression of miR-214 or knockdown of the novel miR-214 targets, ANKRD6 or CTBP1, increased melanoma cell proliferation, migration, and decreased sensitivity to MAPKi. +transcription factor target 31338872 hsa-mir-32 Colonic Neoplasms Therefore, our study indicated that miR-32 enhanced cell proliferation and motility abilities, and inhibited apoptosis by directly targeting OTUD3 in colon cancer cells, which implied that miR-32 was hopeful to be a biomarker or target used for diagnosis and therapy of colon cancer. +other 31338869 hsa-mir-23b Aicardi-Goutieres syndrome 5 The expression levels of miR-23b-3p were examined in age-related cataract tissues and LEC cells treated with hydrogen peroxide, showing that miR23b-3p expression levels were upregulated. +lncRNA target 31338869 hsa-mir-23b Cataract The expression levels of miR-23b-3p were examined in age-related cataract tissues and LEC cells treated with hydrogen peroxide, showing that miR23b-3p expression levels were upregulated. Taken together, our findings revealed that miR-23b-3p regulated apoptosis and autophagy via suppressing SIRT1 in LEC cell under oxidative stress, which could provide new ideas for clinical treatment of cataract. +other 31338525 hsa-mir-146b Ventricular Dysfunction * A novel miR-146b-TRAF6-IL-6/CCL2(MCP-1) axis likely drives cardiac inflammation, fibrosis and ventricular dysfunction. +other 31338525 hsa-mir-146b Cardiomyopathies This novel hypoxia-induced miR-146b-TRAF6-IL-6/CCL2(MCP-1) axis likely drives cardiac fibrosis and dysfunction, and may lead to heart failure. +other 31338525 hsa-mir-146b Hypertrophy, Right Ventricular Hypoxia downregulated miR-146b in the RV (p < 0.01) and, less so, in the LV (trend; p = 0.28). * Hypoxia downregulates miR-146b and induces TRAF6, IL-6, CCL2 (MCP-1) in the murine RV and LV. +transcription factor target 31338525 hsa-mir-146b Long Term Adverse Effects * The inhibitory regulatory effects of miR-146b are confirmed in primary rat cardiomyocytes (pre-miR, anti-miR) and human explant heart tissue (endstage pulmonary arterial hypertension). +other 31338525 hsa-mir-146b Heart Failure This novel hypoxia-induced miR-146b-TRAF6-IL-6/CCL2(MCP-1) axis likely drives cardiac fibrosis and dysfunction, and may lead to heart failure. +other 31338525 hsa-mir-146b Myocarditis * A novel miR-146b-TRAF6-IL-6/CCL2(MCP-1) axis likely drives cardiac inflammation, fibrosis and ventricular dysfunction. +other 31338525 hsa-mir-146b Fibrosis This novel hypoxia-induced miR-146b-TRAF6-IL-6/CCL2(MCP-1) axis likely drives cardiac fibrosis and dysfunction, and may lead to heart failure. * A novel miR-146b-TRAF6-IL-6/CCL2(MCP-1) axis likely drives cardiac inflammation, fibrosis and ventricular dysfunction. +genetics_overexpression_suppress 31337985 hsa-mir-369 Carcinoma, Endometrioid The overexpression of miR +other 31337984 hsa-mir-155 Spinal Injuries Furthermore, miR5p could regulate the cAMP/PKA pathway and promote sensory conduction function recovery post dorsal column injury as detected by NF-200 immunohistochemistry, somatosensory-evoked potentials, BBB scale and tape removal test. +lncRNA target 31337984 hsa-mir-155 Sialic Acid Storage Disease 5p can repair SDCL by enhancing DRG neuron axon growth via the cAMP/PKA pathway. +lncRNA target 31337984 hsa-mir-155 Synucleinopathies 5p can repair SDCL by enhancing DRG neuron axon growth via the cAMP/PKA pathway. +transcription factor target 31337863 hsa-mir-424 Prostatic Neoplasms This highlight the importance of miR3p as potential target for therapeutic treatment in prostate cancer. +lncRNA target 31337739 hsa-mir-211 Melanoma Hence, through this axis of cytokine-mediated repression of miR-211, adipocytes increased the abundance of the TGF-beta receptor in melanoma cells, thereby enhancing cellular responsiveness to TGF-beta ligands. +transcription factor target 31337422 hsa-mir-15a idiopathic scoliosis In addition, Bcl2-targeted miR-15a was downregulated in IS patients, and the level of H3K9me3 in the promoter region of the miR-15a host gene was remarkably increased in IS patients compared with the control group. CONCLUSIONS: Thus, our study suggests that increased chondrocyte proliferation occurs in the facet joint cartilage of IS patients compared with the control group and may be promoted by the elevated levels of H3K9me3 and SUV39H1, which regulate the miR-15a/Bcl2 pathway. +transcription factor target 31337279 hsa-mir-4262 Carcinoma, Non-Small-Cell Lung Our results indicate that miR-4262 enhances PTX resistance in NSCLC cells through targeting PTEN and activating the PI3 K/Akt signalling pathway. +lncRNA target 31337246 hsa-mir-296 Triple Negative Breast Neoplasms 5p-PLK1 axis regulates tumor progression by ceRNA mechanism in TNBC, indicating that circPLK1 may serve as a prognostic factor and novel therapeutic target for TNBC. +other 31336316 hsa-mir-1287 Breast Neoplasms Moreover, circ-UBE2D2-induced tumor-promoting effects could be effectively blocked by miR-1236 or miR-1287 in BC cells. +other 31336316 hsa-mir-1236 Breast Neoplasms Moreover, circ-UBE2D2-induced tumor-promoting effects could be effectively blocked by miR-1236 or miR-1287 in BC cells. +genetics_overexpression_promote 31336236 hsa-mir-429 Pancreatic Carcinoma We found that miR-200a, miR-429, and miR-205 are frequently overexpressed in pancreatic tumors, whereas CDH1 is downregulated, and ZEB1 and ZEB2 levels remain unchanged. +lncRNA target 31336125 hsa-mir-23a Epilepsy, Temporal Lobe Thus, targeting miR-23a in the epileptic brain may provide a novel strategy for protecting against hippocampal neuronal injuries and improving spatial memory in TLE patients. +lncRNA target 31336052 hsa-mir-449b Diabetic Nephropathies The topological key lncRNA H2k2 from the ceRNA network promotes mesangial cell proliferation in diabetic nephropathy via the miR-449a/b/Trim11/Mek signaling pathway. +lncRNA target 31336052 hsa-mir-449a Diabetic Nephropathies The topological key lncRNA H2k2 from the ceRNA network promotes mesangial cell proliferation in diabetic nephropathy via the miR-449a/b/Trim11/Mek signaling pathway. +other 31335671 hsa-mir-191 Prostatic Neoplasms Multivariate analysis revealed that miR-191 expression (hazard ratio [HR]=2.311, 95% confidence interval, [CI]: 1.666-9.006; P=.027) was independently associated with the overall survival of prostate cancer patients.Our results demonstrated that miR-191 might serve as an independent prognostic indicator for prostate cancer patients. +lncRNA target 31334597 hsa-mir-181c Ischemic Stroke This study revealed a novel function of SNHG6 in the modulating neuronal apoptosis in the ischaemic stroke model, and the role of SNHG6 in the regulating of neuronal apoptosis was at least partly via targeting miR-181c-5p/BIM signalling pathway. +other 31334580 hsa-mir-191 Carcinoma, Hepatocellular CONCLUSIONS: Our study sheds light on the novel underlying mechanism of miR-191 in HCC, which may accelerate the development of cancer therapy. +circulation_biomarker_diagnosis_ns 31333735 hsa-mir-181a Diabetes Mellitus, Type 2 The aim of this study was to analyze the expressions of microRNAs (miRNAs) (miR-34a, miR-9, miR-132, and miR-181a) involved in SIRT1 regulation and SIRT1 protein in the serum of T2DM patients and controls. CONCLUSION: Obtained results indicate that serum SIRT1 may be a potentially new biomarker for T2DM and also miR-181a and miR-132 may be involved in the development of T2DM by targeting SIRT1. +circulation_biomarker_diagnosis_ns 31333735 hsa-mir-132 Diabetes Mellitus, Type 2 The aim of this study was to analyze the expressions of microRNAs (miRNAs) (miR-34a, miR-9, miR-132, and miR-181a) involved in SIRT1 regulation and SIRT1 protein in the serum of T2DM patients and controls. CONCLUSION: Obtained results indicate that serum SIRT1 may be a potentially new biomarker for T2DM and also miR-181a and miR-132 may be involved in the development of T2DM by targeting SIRT1. +lncRNA target 31333725 hsa-mir-211 Osteosarcoma CONCLUSIONS: Our study indicated that miR211 has an important role in the development and progress of osteosarcoma, and it might become a novel target in the diagnosis and treatment of human osteosarcoma. +genetics_GWAS 31333395 hsa-mir-34c Alzheimer Disease Furthermore, SNP analysis of the AD-associated genes identified 173 SNPs, and also found a role in AD for miRNAs specific to other neurodegenerative diseases, including hsa-miR-34c, hsa-miR-212, hsa-miR-34a, and hsa-miR-7. +genetics_GWAS 31333395 hsa-mir-34a Alzheimer Disease Furthermore, SNP analysis of the AD-associated genes identified 173 SNPs, and also found a role in AD for miRNAs specific to other neurodegenerative diseases, including hsa-miR-34c, hsa-miR-212, hsa-miR-34a, and hsa-miR-7. +genetics_GWAS 31333395 hsa-mir-212 Alzheimer Disease Furthermore, SNP analysis of the AD-associated genes identified 173 SNPs, and also found a role in AD for miRNAs specific to other neurodegenerative diseases, including hsa-miR-34c, hsa-miR-212, hsa-miR-34a, and hsa-miR-7. +genetics_GWAS 31333395 hsa-mir-7 Alzheimer Disease Furthermore, SNP analysis of the AD-associated genes identified 173 SNPs, and also found a role in AD for miRNAs specific to other neurodegenerative diseases, including hsa-miR-34c, hsa-miR-212, hsa-miR-34a, and hsa-miR-7. +other 31333331 hsa-mir-29c Leukemia, Myeloid, Acute Conclusions Our results suggest that miR-29c down-regulation may act as an independent prognostic biomarker in AML patients, and miR-29c over-expression can increase the sensitivity of both non-resistant and resistant of leukemic cells to DAC. +other 31333145 hsa-mir-138 Cardiomyopathy, Alcoholic CONCLUSION: The downregulation of miR-133b might be a marker for ACM and, in addition, miR- 138 could be used to correlate the increase in ejection fraction with and normalization of the diameter of the left atrium diameter in patients with this disease. +tissue_expression_ns 31332950 hsa-mir-498 Prostatic Neoplasms In this study, we examined the effect of miR-498 on proliferation, radiosensitivity, invasion, and migration of PCa cells. The proliferation of LNCaP and DU-145 PCa cells with altered expression of miR-498 was evaluated by MTT assay. The function of miR-498 on radiation-induced apoptosis in LNCaP and DU-145 PCa cells was detected by Caspase-Glo3/7 assay. Forced expression of miR-498 improved the proliferation, invasion and migration in PCa cells. Furthermore, miR-498 decreased the sensitivity of PCa cells after ionizing radiation treatment. MiR-498 reduced the radiation-induced apoptosis in PCa cells by regulation of BAX and Bcl-2 expression. Meanwhile, miR-498 altered the expression of E-cadherin, N-cadherin, snail, and Vimentin in both LNCaP and DU-145 PCa cells and regulated epithelial to mesenchymal transition (EMT). Further study showed that aberrant expression of miR-498 changed the expression levels of phosphatase and tensin homolog and p-AKT in LNCaP and DU-145 PCa cells. In a summary, miR-498 displayed important roles in tumor development and progression in PCa cells, and might act as a potential prognostic biomarker and predict radiotherapy response in PCa. +transcription factor target 31332786 hsa-mir-363 Carcinoma, Non-Small-Cell Lung 3p may be a potential target in NSCLC therapy. +lncRNA target 31332786 hsa-mir-363 Adenocarcinoma of Lung miR3p is downregulated in lung adenocarcinoma and can inhibit tumor growth. +other 31332443 hsa-mir-204 Inflammation Together, these in vitro and in vivo experiments suggest that the normally high levels of miR-204 in RPE can mitigate disease onset by preventing generation of oxidative stress and inflammation originating from intracellular accumulation of undigested photoreactive POS lipids. +transcription factor target 31331947 hsa-mir-142 Pneumonia Furthermore, restoration of intracellular miR-223/142 via vesicle-mediated delivery suppresses macrophage activation and lung inflammation via inhibition of Nlrp3 inflammasome activation. +transcription factor target 31331947 hsa-mir-223 Pneumonia Furthermore, restoration of intracellular miR-223/142 via vesicle-mediated delivery suppresses macrophage activation and lung inflammation via inhibition of Nlrp3 inflammasome activation. +lncRNA target 31331909 hsa-mir-590 Nasopharyngeal Carcinoma 3p and miR-1275, leading to the upregulation of their target integrin beta3 (ITGB3), and the activation of FAK/PI3K/Akt signaling to promote NPC cell proliferation and invasion. +other 31331349 hsa-let-7c Diabetic Nephropathies 3p) that were uniquely up-regulated in DN patients compared to HVs, and miR-4449 that was highly expressed in DN patients compared to patients without DN. +other 31331349 hsa-mir-4449 Diabetic Nephropathies 3p) that were uniquely up-regulated in DN patients compared to HVs, and miR-4449 that was highly expressed in DN patients compared to patients without DN. +other 31331349 hsa-mir-5010 Diabetic Nephropathies 3p) that were uniquely up-regulated in DN patients compared to HVs, and miR-4449 that was highly expressed in DN patients compared to patients without DN. +other 31331349 hsa-mir-1246 Diabetic Nephropathies 3p) that were uniquely up-regulated in DN patients compared to HVs, and miR-4449 that was highly expressed in DN patients compared to patients without DN. +other 31331349 hsa-let-7i Diabetic Nephropathies 3p) that were uniquely up-regulated in DN patients compared to HVs, and miR-4449 that was highly expressed in DN patients compared to patients without DN. +other 31331349 hsa-mir-642a Diabetic Nephropathies 3p) that were uniquely up-regulated in DN patients compared to HVs, and miR-4449 that was highly expressed in DN patients compared to patients without DN. +transcription factor target 31331056 hsa-mir-1208 Carcinoma, Renal Cell These findings suggest that miR-1208 acts as a tumor suppressor and targets TBCK directly, thus possessing great potential for use in renal cancer therapy. +lncRNA target 31330869 hsa-mir-155 Rotavirus Infections The present study was performed to investigate whether VD alleviates rotavirus (RV) infection through a microRNA +lncRNA target 31330497 hsa-mir-101 Stomach Neoplasms 3p and decreasing inhibiting AMPK expression. +circRNA target 31330234 hsa-mir-766 Carcinoma, Hepatocellular 3p/MTA3 regulatory axis may be an effective therapeutic target for HCC. +genetics_overexpression_promote 31330207 hsa-mir-146a Borna Disease Overexpression and suppression studies of miR-146a were performed to determine its effect on BoDV-1 replication. +lncRNA target 31330194 hsa-mir-15b Fatty Liver Taken together, the results suggested that ENST00000608794 plays an important role in dexamethasone induced steatosis, which was partly mediated by derepressing of PDK4 through competitively binding to miR-15b-5p. +other 31330059 hsa-mir-21 Inflammation In this study, we aim to investigate the biological functions of miR3p in inflammation and apoptosis caused by lipopolysaccharide (LPS) in human retinal pigment epithelial (ARPE-19) cells. +genetics_knock down_promote 31329335 hsa-mir-214 Carcinoma, Hepatocellular Functional analysis showed that knockdown of PDK2 or PHF6 as well as miR-214 overexpression significantly suppressed cell proliferation and migration in HCC cells. +transcription factor target 31328811 hsa-mir-25 Carcinoma, Non-Small-Cell Lung Luciferase reporter assay suggested that KIF2C was a target gene of miR3p, which was reported to be a tumour suppressor in NSCLC. +other 31328772 hsa-mir-27a Hypertension We aimed to determine the role of monocyte miR-27a in EVs on arterial Mas receptor expression, and its involvement in the pathogenesis of hypertension. CONCLUSIONS: Monocyte miR-27a in EVs decreases Mas receptor expression and eNOS phosphorylation in endothelium, impairs Ang-(1-7)-mediated vasodilation, and causes hypertension. +other 31328772 hsa-mir-27 Hypertension We aimed to determine the role of monocyte miR-27a in EVs on arterial Mas receptor expression, and its involvement in the pathogenesis of hypertension. CONCLUSIONS: Monocyte miR-27a in EVs decreases Mas receptor expression and eNOS phosphorylation in endothelium, impairs Ang-(1-7)-mediated vasodilation, and causes hypertension. +other 31328388 hsa-mir-23a Laryngeal Neoplasms Furthermore, MEG3 may act as a ceRNA to regulate APAF-1 expression by competitive binding to miR-23a, thereby regulating the progression of laryngeal cancer. +lncRNA target 31327761 hsa-mir-548d Osteosarcoma In osteosarcoma cells, miR-548d-3p exerted tumor-suppressive effects by downregulating KRAS. +transcription factor target 31327495 hsa-mir-545 Osteoporosis Remarkably, strategies targeting miR +lncRNA target 31326971 hsa-mir-29c Carcinoma, Non-Small-Cell Lung MATERIAL AND METHODS To explore the role of PVT1 in NSCLC, qRT-PCR, Western blot, luciferase reporter assay, and ELISA were carried out for detecting the relationship among PVT1, miR-29c, and VEGF. CONCLUSIONS We found that PVT1 promotes angiogenesis through targeting the miR-29c/VEGF signaling pathway in NSCLC. +circulation_biomarker_diagnosis_up 31326963 hsa-let-7f Multiple Sclerosis In contrast to the downregulated expression of let-7f-5p, STAT3 and p-STAT3 protein levels were dramatically upregulated and inversely correlated with let-7f-5p in peripheral blood CD4(+) T cells from MS patients. +transcription factor target 31326581 hsa-mir-145 Colorectal Neoplasms The main objective of this work was to explore the full potential of protamine nanocapsules (Pr NCs) to develop an anticancer therapy based on the restoration of oncosuppressor miR-145, downregulated in colorectal cancer cells. After exposure of colorectal cancer cells with (i) miR-145 and (ii) curcumin-loaded Pr NCs, a strong increase in the intracellular levels of miR-145, which translated into a decreased cell proliferation rate and migration capacity of the treated cells, was observed. +epigenetics 31326568 hsa-mir-196a-1 Uterine Cervical Neoplasms To study the DNA methylation regulation of miRNAs and its potential role in cervical cancer, we investigated the differential methylation pattern of two candidate miRNAs (miR-375 and miR-196a-1) during cervical cancer progression against normal cervical epithelium (NCE) by bisulfite DNA sequencing. Our analysis indicates that miR-375 and miR-196a-1 are DNA methylation regulated miRNAs whose deregulation may facilitate pathophysiology of cervical cancer. +epigenetics 31326568 hsa-mir-375 Uterine Cervical Neoplasms To study the DNA methylation regulation of miRNAs and its potential role in cervical cancer, we investigated the differential methylation pattern of two candidate miRNAs (miR-375 and miR-196a-1) during cervical cancer progression against normal cervical epithelium (NCE) by bisulfite DNA sequencing. Our analysis indicates that miR-375 and miR-196a-1 are DNA methylation regulated miRNAs whose deregulation may facilitate pathophysiology of cervical cancer. +other 31326400 hsa-mir-21 Venous Neointimal Hyperplasia The role of microRNA-21 (miR-21) in VNH associated with AVF failure was investigated by performing in vivo and in vitro experiments. These results indicate that miR-21 upregulation causes VNH formation by fibroblast-to-myofibroblast differentiation. +transcription factor target 31326116 hsa-mir-152 Ischemic Stroke 3p is a potential target for neuroprotection during ischemic stroke. +genetics_GWAS 31325764 hsa-mir-34b Neuroblastoma We found that both TP53 Arg72Pro (CG/GG vs. CC: adjusted OR=0.82, 95% CI=0.69-0.98) and miR-34b/c rs4938723 (TC/CC vs. TT: adjusted OR=0.64, 95% CI=0.54-0.75) were associated with decreased neuroblastoma susceptibility. Overall, we confirmed that miR-34b/c rs4938723 and TP53 Arg72Pro conferred decreased neuroblastoma risk and two polymorphisms exerted stronger protective effects against neuroblastoma than either one alone. +lncRNA target 31325726 hsa-mir-146a Lichen Planus, Oral In conclusion, these findings indicate that DQ786243 may regulate the induction and function of CD4(+) Treg cells through Foxp3-miR-146a-NF-kappaB axis, implicating a novel insight into understanding the progression of OLP. +lncRNA target 31325708 hsa-mir-125a Head and Neck Neoplasms Our data suggests that miR-125a-5p acts as a tumor suppressor miRNA, has potential as a diagnostic tool and may be a potential therapeutic target for the management and treatment of squamous cell carcinoma of the head and neck. +other 31325486 hsa-mir-149 Prostatic Neoplasms Overall, it is here demonstrated that the rG4 found in pre-miR-149 can be used as a cancer-selective delivery carrier of C(8) to prostate cancer cells. +transcription factor target 31325434 hsa-mir-132 Cardiomegaly In vitro experiments demonstrated that Ang II-induced cardiomyocyte hypertrophy and proliferation and activation of cardiac fibroblasts were markedly inhibited by klotho, LY364947 or the miR-132 inhibitor anti-miR-132. +transcription factor target 31325434 hsa-mir-132 Diabetic Nephropathies In vitro experiments demonstrated that Ang II-induced cardiomyocyte hypertrophy and proliferation and activation of cardiac fibroblasts were markedly inhibited by klotho, LY364947 or the miR-132 inhibitor anti-miR-132. +genetics_overexpression_suppress 31325426 hsa-mir-99a Atherosclerosis In vivo, the specific overexpression of miR-99a-5p significantly abated atherosclerotic lesions formatted, accompanied with a significant down-regulation of HOXA1 mRNA and protein expression levels. +lncRNA target 31325400 hsa-mir-96 Carcinoma, Pancreatic Ductal Mechanistically, TP53TG1 could directly bind to microRNA (miR)-96 and effectively function as a sponge for miR-96, thus antagonizing the functions of miR-96 and leading to derepression of its endogenous target KRAS, which is a core oncogene in the initiation and maintenance of PDAC. Taken together, these observations imply that TP53TG1 contributes to the growth and progression of PDAC by acting as a competing endogenous RNA (ceRNA) to competitively bind to miR-96 and regulate KRAS expression, which highlights the importance of the complicated miRNA-lncRNA network in modulating the progression of PDAC. +transcription factor target 31325197 hsa-mir-34a Breast Neoplasms Western blot analysis confirmed that delphinidin treatment can significantly decrease the expression of beta-catenin, glycogen synthase kinase-3beta (Gsk3beta), c-Myc, cyclin-D1, and matrix metalloproteinase-7(MMP-7) expression in breast cancer cells, and inhibition of miR-34a significantly reduced the effect of delphinidin on c-Myc, cyclin-D1, and MMP-7. +virus_miRNA 31325192 hsv1-mir-H18 Esophageal Achalasia HSV-1-derived hsv1-miR-H1 and -H18 was significantly overexpressed in achalasia cohorts compared to controls. +virus_miRNA 31325192 hsv1-mir-H1 Esophageal Achalasia HSV-1-derived hsv1-miR-H1 and -H18 was significantly overexpressed in achalasia cohorts compared to controls. +genetics_overexpression_promote 31324391 hsa-mir-429 Esophageal Squamous Cell Carcinoma Furthermore, overexpression of endogenous miR-429 inhibited the migration and invasion of ESCC cell lines. +lncRNA target 31324390 hsa-mir-24 Prostatic Neoplasms Overall, our study suggested that lncRNA SNHG7 could promote PCa EMT via miR +lncRNA target 31324142 hsa-mir-34a Visceral Pain CONCLUSIONS: DEX thus exhibited an analgesic effect on CIVP rats through the miR-34a-mediated HDAC2 pathway and suppressed visceral hypersensitivity. +other 31323679 hsa-mir-216a Endometriosis Alterations in the H19/miR-216a-5p/ACTA2 pathway may mediate the regulation of eutopic endometrial stromal cell (euESC) invasion and migration and may represent a potential mechanism underlying fibrous tissue formation or fibrosis in women with endometriosis. Our results indicate that alterations in the estrogen/H19/miR-216a-5p/ACTA2 pathway regulated endometriosis euESC invasion and migration. +lncRNA target 31323309 hsa-mir-544 Inflammation In conclusion, our finding demonstrated that miR-544 attenuates diabetic renal injury via suppressing glomerulosclerosis and inflammation by targeting FASN, suggesting that miR-544 might have therapeutic potential for the treatment of DN. +lncRNA target 31323309 hsa-mir-544 Diabetic Nephropathies In conclusion, our finding demonstrated that miR-544 attenuates diabetic renal injury via suppressing glomerulosclerosis and inflammation by targeting FASN, suggesting that miR-544 might have therapeutic potential for the treatment of DN. +lncRNA target 31323181 hsa-mir-35 Fibromatosis, Gingival Thus, our study first proposes a novel miRNA screening approach targeting a functionally related gene set and identifies miR +lncRNA target 31323164 hsa-mir-126 Pre-Eclampsia The finding of increased anti-inflammatory property by 1,25(OH)(2) D(3) through promotion of VDR and miR +lncRNA target 31323152 hsa-mir-138 Squamous Cell Carcinoma of Head and Neck Therefore, our study confirms that microRNA-138 serves as a tumor suppressor and plays a functional role in oral squamous cell carcinoma tumor metastasis; microRNA-138 constitutes a promising prognosis biomarker and therapeutic target for oral squamous cell carcinoma with metastasis potential. +genetics_GWAS 31323027 hsa-mir-140 Bone Regeneration 5p markedly contributes to the development of nonunions, most probably by affecting bone morphogenetic protein (BMP)-2 function during the early stage of healing due to a reduced SDF-1alpha expression. +genetics_overexpression_promote 31322550 hsa-mir-429 Melanoma Furthermore, the results showed that the mRNA and protein expression levels of AKT1 were downregulated in the melanoma cell lines when miR429 was overexpressed according to qRT-PCR and western bolt, indicating MicroRNA-429 may directly target AKT1 in melanoma. +genetics_overexpression_promote 31322549 hsa-mir-939 Lung Neoplasms After the transfection of miR-939 mimic, overexpression of miR +lncRNA target 31322545 hsa-mir-424 Carcinoma, Non-Small-Cell Lung Through mechanism investigation, we determined that LINC00641 acted as a competing endogenous RNA (ceRNA) in NSCLC by sponging miR5p to upregulate phospholipid scramblase (PLSCR4) expression. +other 31322518 hsa-mir-155 Epstein-Barr Virus Infections Aim - to assess the levels of miR-146a and miR-155 expression in patients with allergopathy in combination with active and latent phases of EBV infection. +other 31322518 hsa-mir-146a Epstein-Barr Virus Infections Aim - to assess the levels of miR-146a and miR-155 expression in patients with allergopathy in combination with active and latent phases of EBV infection. +circulation_biomarker_diagnosis_ns 31322515 hsa-mir-133a Essential Hypertension The aim of research was to investigate the plasma microRNA (miR-133small a, Cyrillic) level in patients with essential arterial hypertension (EAH). The findings suggest the significant role of reducing of plasma levels of miR-133a in the pathogenesis of hypertension itself and in pathological remodeling of the heart. +other 31322277 hsa-let-7a Osteoarthritis The present study aimed to investigate the role and mechanism of microRNAlet7a (Let7a) in OA by examining its role in lipopolysaccharide (LPS)induced cartilage inflammatory injury in ATDC5 cells. +other 31322277 hsa-let-7a Cartilage Diseases The present study aimed to investigate the role and mechanism of microRNAlet7a (Let7a) in OA by examining its role in lipopolysaccharide (LPS)induced cartilage inflammatory injury in ATDC5 cells. +genetics_overexpression_promote 31322262 hsa-mir-198 Prostatic Neoplasms Overexpression of miR198 diminished proliferation of prostate cancer cell lines, increased G0/G1 cell cycle arrest, and significantly impaired colony formation. +lncRNA target 31322249 hsa-mir-143 Glioma Furthermore, miR143 inhibited glioma cells migration and invasion through cytoskeletal rearrangement in vitro and in vivo through matrigel invasion assay, scratch assay, cellular Factin measurement, chemotaxis assay and intracranial brain tumor xenografts. +genetics_overexpression_promote 31322243 hsa-mir-543 Squamous Cell Carcinoma of Head and Neck Overexpression of miR543 promoted the proliferation, invasion and migration of OSCC cell lines, and inhibited cell apoptosis. +lncRNA target 31322230 hsa-mir-206 Carcinoma, Non-Small-Cell Lung The experimental results also suggested that LINC00887 can stimulate miR613, miR206 and miR12 to become competing endogenous RNAs, which may regulate the epithelialmesenchymal transition of NSCLC cells through the transforming growth factora signal transduction pathway, and therefore promote the migration of cells and the acquisition of stem cell characteristics. +lncRNA target 31322230 hsa-mir-613 Carcinoma, Non-Small-Cell Lung The experimental results also suggested that LINC00887 can stimulate miR613, miR206 and miR12 to become competing endogenous RNAs, which may regulate the epithelialmesenchymal transition of NSCLC cells through the transforming growth factora signal transduction pathway, and therefore promote the migration of cells and the acquisition of stem cell characteristics. +lncRNA target 31322230 hsa-mir-12 Carcinoma, Non-Small-Cell Lung The experimental results also suggested that LINC00887 can stimulate miR613, miR206 and miR12 to become competing endogenous RNAs, which may regulate the epithelialmesenchymal transition of NSCLC cells through the transforming growth factora signal transduction pathway, and therefore promote the migration of cells and the acquisition of stem cell characteristics. +genetics_knock down_suppress 31322228 hsa-mir-671 Osteoarthritis, Knee Through gainoffunction and lossoffunction experiments, miR6713p was shown to significantly affect matrix synthesis gene expression, cell proliferation, apoptosis and inflammation in chondrocytes from patients with OA. +genetics_overexpression_promote 31322226 hsa-mir-140 Helicobacter pylori Overexpression of miR140 significantly suppressed gastric cancer cell proliferation through regulating PDL1 expression. +genetics_overexpression_promote 31322226 hsa-mir-140 Stomach Neoplasms Overexpression of miR140 significantly suppressed gastric cancer cell proliferation through regulating PDL1 expression. +genetics_overexpression_suppress 31322222 hsa-mir-539 Stomach Neoplasms Notably, SOX5 overexpression attenuated the inhibitory effect of miR539 on gastric cancer cells. +lncRNA target 31322217 hsa-mir-16 Uterine Cervical Neoplasms In summary, LncRNA PVT1 inhibits the effect of miR16, promoting the cell cycle and inhibiting cellular apoptosis of cervical cancer cells, potentially via the NFB pathway. +other 31322216 hsa-mir-98 Hypertension, Pulmonary In the present study, the expression of miR98 was identified to be decreased in the lung tissue of a hypoxic pulmonary hypertension (HPH) rat model and pulmonary artery (PA) smooth muscle cells (PASMCs), which was induced by hypoxia. These results provided clear evidence that miR98 was a direct regulator of ALK1, and that the downregulation of miR98 contributed to the pathogenesis of HPH. +genetics_overexpression_promote 31322202 hsa-mir-124 Breast Neoplasms Furthermore, miR124 overexpression partially attenuated the effects of NEAT1 on breast cancer cell proliferation and cell cycle progression. +lncRNA target 31322197 hsa-mir-195 lung squamous cell carcinoma The expression levels of miR195 were decreased in two SQCLC cell lines (H520 and SKMes1) compared with a normal lung cell line, and miR195 directly targeted the 3'untranslated region of vascular endothelial growth factor (VEGF) in SQCLC cells. +lncRNA target 31322192 hsa-mir-145 Arthritis, Rheumatoid In conclusion, modulation of miR1455p expression is potentially useful for the treatment of RA inflammation, by regulating the expression of MMPs, and MMP9 in particular, through inhibition of the NFkappaB pathway. +lncRNA target 31322191 hsa-mir-28 Polycystic Ovary Syndrome In the present study, the roles of miR285p and PROK1, and their interaction in PCOS were investigated. The present results suggested that miR285p attenuated the progression of PCOS by targeting PROK1, which may promote the pathogenesis of PCOS via the PI3K/AKT/mTOR pathway, indicating that the miR285p/PROK1 axis may be a potential therapeutic target for patients with PCOS. +other 31322189 hsa-mir-1792 Lymphoma, B-Cell Members of the miR1792 cluster exhibited various expression in the subtypes of BNHL, and the difference between follicular lymphoma (FL) and germinal center Bcell like (GBC) was most marked. +genetics_overexpression_promote 31322187 hsa-mir-30 Osteosarcoma Furthermore, overexpression of survivin significantly abrogated the tumorsuppressive effect induced by miR3305p on OS cells. +genetics_overexpression_promote 31322185 hsa-mir-338 Acute Lymphoblastic Leukemia, T-Cell The levels of HOXA3 mRNA and protein were associated with those of miR3383p, and overexpression of HOXA3 promoted the malignant phenotype of TLBL cells. +circulation_biomarker_diagnosis_up 31321740 hsa-mir-23b Carcinoma, Hepatocellular Here, we show that microRNA-23a/b (miR-23a/b) was significantly upregulated in both serum exosomes and tumor tissues of HCC patients with a high body fat ratio than low BFR. +exosome 31321740 hsa-mir-23a Carcinoma, Hepatocellular Meanwhile, exosome miR-23a and miR-23b confer chemoresistance by targeting the von Hippel-Lindau/hypoxia-inducible factor axis. +lncRNA target 31321444 hsa-mir-16 Prostatic Neoplasms Furthermore, we not only discovered that miR-27a/15a/16 are targeted by ZFAS1, which binds to their miRNA-response elements, but also revealed their tumor suppressor roles in PCa. +lncRNA target 31321444 hsa-mir-15a Prostatic Neoplasms Furthermore, we not only discovered that miR-27a/15a/16 are targeted by ZFAS1, which binds to their miRNA-response elements, but also revealed their tumor suppressor roles in PCa. +lncRNA target 31321444 hsa-mir-27a Prostatic Neoplasms Furthermore, we not only discovered that miR-27a/15a/16 are targeted by ZFAS1, which binds to their miRNA-response elements, but also revealed their tumor suppressor roles in PCa. +other 31320713 hsa-mir-34a Carcinoma, Hepatocellular 5p and miR-148a-3p) in CHB, cirrhosis and HCC patients are potential biomarkers for CHB infection, while miR-34a-5p can be a biomarker for cirrhosis. +other 31320713 hsa-mir-125b Carcinoma, Hepatocellular 5p and miR-148a-3p) in CHB, cirrhosis and HCC patients are potential biomarkers for CHB infection, while miR-34a-5p can be a biomarker for cirrhosis. +other 31320713 hsa-mir-193a Carcinoma, Hepatocellular Notably, four miRNAs (miR-1972, miR-193a-5p, miR3p and miR-365a-3p) can distinguish HCC from other non-HCC individuals. +other 31320713 hsa-mir-1972 Carcinoma, Hepatocellular Notably, four miRNAs (miR-1972, miR-193a-5p, miR3p and miR-365a-3p) can distinguish HCC from other non-HCC individuals. +lncRNA target 31320641 hsa-mir-145 Thoracic Aortic Dissection Such targeted therapy with miR-145 exhibits impressive performances in stabilizing the vascular structures and preventing the deterioration of TAD. +genetics_GWAS 31320614 hsa-mir-483 Liver Neoplasms In summary, this study describes an unknown miRNA-dependent regulatory mechanism between two distinct imprinted loci and a possible therapeutic window for liver cancer patients exhibiting IGF2-miR-483 LOI and amplification. +exosome 31319859 hsa-mir-145 Adenocarcinoma of Lung RESULTS: We propose here the development of exosome-mimetic nanosystems (EMNs) that simulate natural tumor-derived exosomes with respect to their structure and functionality, but with a controlled composition, for the targeted delivery of therapeutic oligonucleotides to lung adenocarcinoma cells (microRNA-145 mimics). +lncRNA target 31319799 hsa-mir-146b Leiomyoma Fifty-five of the selected lncRNAs were predicted to target miR-146b-5p, which is up-regulated in SUL and down-regulated in MUL. +lncRNA target 31319247 hsa-mir-21 Primary Ovarian Insufficiency It also suggested that the GAS5/miR-21a axis may be a potential therapeutic target for premature ovarian failure in the clinic. +genetics_overexpression_promote 31319247 hsa-mir-21 FG syndrome Additionally, overexpression of miR-21a significantly enhanced LC3B-II protein expression while significantly reducing the expression of programmed cell death protein 4 (PDCD4) and SQSTM1 protein in FGSCs compared with control cells. +other 31319246 hsa-mir-92a-2 Diabetic Cardiomyopathies Re-expression of miR-92a5p enhances mitochondrial translation and reduces ROS production and lipid deposition, which finally rescues diabetic cardiomyopathy. +other 31319246 hsa-mir-92a-2 Heart Failure, Diastolic Furthermore, recombinant adeno-associated virus (rAAV)-mediated delivery of miR-92a5p, but not let-7b-5p, was sufficient to rescue cardiac diastolic dysfunction in db/db heart. +circulation_biomarker_prognosis_ns 31319245 hsa-mir-125b-1 Head and Neck Neoplasms A case study conducted on head and neck neoplasms further identified two potential prognostic biomarkers, hsa-mir-125b-1 and hsa-mir-125b-2, for the disease. +circulation_biomarker_prognosis_ns 31319245 hsa-mir-125b Head and Neck Neoplasms A case study conducted on head and neck neoplasms further identified two potential prognostic biomarkers, hsa-mir-125b-1 and hsa-mir-125b-2, for the disease. +other 31319144 hsa-mir-146a Pulmonary Disease, Chronic Obstructive These results indicate the optimal process parameters for the preparation of NCMPs of miR-146a-containing PGA-co-PDL NPs suitable for inhalation in the treatment and management of COPD. +genetics_knock down_promote 31318685 hsa-mir-26a Carcinoma, Hepatocellular Knockdown of Linc01296 suppressed HCC cell processes, such as proliferation, migration and invasion, and enhanced apoptosis in vitro; these effects were reversed by a miR-26a mimic or PTEN overexpression. These findings indicated that Linc01296 is involved in HCC progression via regulating miR-26a/PTEN. +lncRNA target 31318608 hsa-mir-432 Urinary Bladder Neoplasms Down-regulated RBM5 inhibits bladder cancer cell apoptosis by initiating an miR +lncRNA target 31318114 hsa-mir-195 Stomach Neoplasms Mechanistically, GPRC5A was predicted as a target of miR-195 and was upregulated in gastric cancer. CONCLUSIONS: Hsa_circ_006100 functions as an oncogene in gastric cancer and exerts its effects via miR-195/GPRC5A signalling. +lncRNA target 31318097 hsa-mir-223 Coronary Artery Disease This study evaluated PBMC expressions of STAT1, and its regulators (miR-150 and miR-223) in a cohort including 72 patients with CAD with significant ( >/= 50%) stenosis, 30 patients with insignificant ( < 50%) coronary stenosis (ICAD), and 74 healthy controls, and assessed potential of PBMC expressions to discriminate between patients and controls. In conclusion, the present study reported PBMC dysregulations of STAT1, miR-150, and miR-223, in patients with significant or insignificant coronary stenosis and suggested that these changes may have diagnostic implications. +lncRNA target 31318097 hsa-mir-150 Coronary Artery Disease This study evaluated PBMC expressions of STAT1, and its regulators (miR-150 and miR-223) in a cohort including 72 patients with CAD with significant ( >/= 50%) stenosis, 30 patients with insignificant ( < 50%) coronary stenosis (ICAD), and 74 healthy controls, and assessed potential of PBMC expressions to discriminate between patients and controls. In conclusion, the present study reported PBMC dysregulations of STAT1, miR-150, and miR-223, in patients with significant or insignificant coronary stenosis and suggested that these changes may have diagnostic implications. +lncRNA target 31318050 hsa-mir-182 Sepsis Studies have shown that miR5p can serve as a tumor oncogene or a tumor suppressive microRNA in various cancers, however, its biological role in sepsis is still uninvestigated. +lncRNA target 31318050 hsa-mir-182 Intestinal Diseases Studies have shown that miR5p can serve as a tumor oncogene or a tumor suppressive microRNA in various cancers, however, its biological role in sepsis is still uninvestigated. +lncRNA target 31318050 hsa-mir-182 Pneumonia, Staphylococcal Studies have shown that miR5p can serve as a tumor oncogene or a tumor suppressive microRNA in various cancers, however, its biological role in sepsis is still uninvestigated. +other 31317555 hsa-mir-377 Carcinoma, Hepatocellular This study systematically investigated novel regulatory signaling of hsa_circRNA_103809/miR3p/FGFR1 axis, providing insights into hepatocellular carcinoma treatment from bench to clinic. +genetics_knock down_suppress 31317324 hsa-mir-4500 Thyroid Cancer, Papillary PLXNC1 knockdown showed similar effects on cell viability, colony formation, and cell apoptosis as overexpression of miR-4500 in PTC cells. +other 31317136 hsa-mir-122 Liver Neoplasms The miRNA nanotherapeutics, activatable by stepwise stimulation of acidity and reduction mimicking tumor microenvironment, efficiently improve liver-specific miR-122 expression, increasing the possibility of translational application of miR-122 therapy against liver cancer. +other 31316949 hsa-mir-222 Mucocutaneous Lymph Node Syndrome 3p in platelets as biomarker for early diagnosis of Kawasaki disease. +circulation_biomarker_diagnosis_up 31316774 hsa-mir-141 Colorectal Neoplasms 3p and miR-200c-3p in serum of adenoma patients compared with the CRC group. +circulation_biomarker_diagnosis_up 31316774 hsa-mir-200c Colorectal Neoplasms 3p and miR-200c-3p in serum of adenoma patients compared with the CRC group. +circulation_biomarker_diagnosis_up 31316774 hsa-mir-200c Colorectal Adenocarcinoma 3p and miR-200c-3p in serum of adenoma patients compared with the CRC group. +circulation_biomarker_diagnosis_up 31316774 hsa-mir-141 Colorectal Adenocarcinoma 3p and miR-200c-3p in serum of adenoma patients compared with the CRC group. +circulation_biomarker_diagnosis_up 31316774 hsa-mir-143 Colorectal Neoplasms 3p and miR-200c-3p in serum of adenoma patients compared with the CRC group. +circulation_biomarker_diagnosis_up 31316774 hsa-mir-143 Colorectal Adenocarcinoma 3p and miR-200c-3p in serum of adenoma patients compared with the CRC group. +genetics_overexpression_promote 31316723 hsa-mir-25 Carcinoma, Non-Small-Cell Lung Given that oxidative stress induces the overexpression of miR-25 and plays a critical role in cancer progression, this study establishes miR-25 as an intermediate between oxidative stress and lung cancer metastasis. +transcription factor target 31316620 hsa-mir-24 Glioma To the best of our knowledge, the present study is the first to demonstrate whether beta-catenin regulates the intracellular effects of miR-24 on the viability and autophagy of glioma cells. +lncRNA target 31316599 hsa-mir-130b Wilms Tumor To better understand the functions and the molecular mechanisms of miR-130b-3p in nephroblastoma, TargetScan was used to identify the potential targets of miR-130b-3p. +circulation_biomarker_diagnosis_down 31316598 hsa-mir-628 Prostatic Neoplasms The serum expression levels of miR-628, prostate-specific antigen, fibroblast growth factor 1, and FGFR2 were examined in patients with PCa. +other 31316543 hsa-mir-433 Cardiomyopathies The circNFIB-miR-433 axis may represent a novel therapeutic approach for treatment of fibrotic diseases. +circulation_biomarker_diagnosis_ns 31316517 hsa-mir-146a Arthritis, Rheumatoid RA miR-146a was associated with greater concentrations of cardiometabolic risk markers (plasma short-chain dicarboxyl/hydroxyl acylcarnitines, triglycerides, large VLDL particles, and small HDL particles) and lower concentrations of muscle energy substrates (long-chain acylcarnitines and pyruvate). +circulation_biomarker_prognosis_up 31315725 hsa-mir-122 Respiratory Distress Syndrome CONCLUSIONS Elevated serum miR-122 expression level is associated with disease severity and prognosis of ARDS patients; miR-122 combination with APACHE II score has a high evaluation value on prognosis of ARDS patients. +circulation_biomarker_diagnosis_up 31315362 hsa-let-7a Laryngeal Neoplasms There was a positive correlation between the relative expression of let-7a in laryngeal carcinoma and that in serum (r=0.466,P=0.003). +transcription factor target 31314587 hsa-mir-183 Prostatic Neoplasms 3p-HMGN5 axis plays an oncogenic role and can be a therapeutic target for prostate cancer. +genetics_GWAS 31314552 hsa-mir-143 Lung Neoplasms The study aimed to explore the association between rs3733845 and rs3733846 polymorphisms in the promoter region of miR-143/145 and the risk of lung cancer among 575 nonsmoking cases and 575 cancer-free controls in a Chinese female population. Logistic regression analysis was conducted to assess the association between polymorphisms in the promoter of miR-143/miR-145 and risk of lung cancer females. +genetics_GWAS 31314552 hsa-mir-145 Lung Neoplasms The study aimed to explore the association between rs3733845 and rs3733846 polymorphisms in the promoter region of miR-143/145 and the risk of lung cancer among 575 nonsmoking cases and 575 cancer-free controls in a Chinese female population. Logistic regression analysis was conducted to assess the association between polymorphisms in the promoter of miR-143/miR-145 and risk of lung cancer females. +transcription factor target 31313842 hsa-mir-29b-1 Triple Negative Breast Neoplasms 5p/AKT regulatory loop that can regulate the fate (life/death) of MDA-MB-231 cells and suggests this loop as therapeutic target for TNBC. +other 31313741 hsa-mir-222 Pulmonary Arterial Hypertension RESULTS: Data from the present study showed significantly increased lnc-Ang362, miR-221, and miR-222 expression in the lung tissues of patients with PAH and in hypoxic HPASMCs. +other 31313741 hsa-mir-221 Pulmonary Arterial Hypertension RESULTS: Data from the present study showed significantly increased lnc-Ang362, miR-221, and miR-222 expression in the lung tissues of patients with PAH and in hypoxic HPASMCs. +lncRNA target 31313295 hsa-mir-200b Diabetic Retinopathy From these data, we conclude that YAP1 may exert some promotive effects on the development of DR through its regulation of the MALAT1/miR-200b-3p/VEGFA axis, highlighting that YAP1 silencing may be instrumental for the therapeutic targeting of DR. +transcription factor target 31313286 hsa-mir-501 Colorectal Neoplasms Taken together, our data indicated that modification of ERRFI1 by KHSRP occurs through miR +lncRNA target 31313025 hsa-mir-26a Pseudarthrosis In conclusion, we demonstrated that miR-26a promoted fracture healing of rats with nonunion in vivo and osteogenic differentiation of MSCs in vitro, possibly by targeting SOSTDC1, and that Wnt/beta-catenin signaling pathway was involved in this process. +other 31312877 hsa-mir-221 Cardiomegaly Next generation sequencing revealed 14 differentially expressed miRs in hypertrophic hearts, with miR-221 and -222 being the strongest regulated miR-cluster. Additionally, we evaluated the change of miR-221/222 in vivo in two models of pharmacologically induced heart hypertrophy (angiotensin II, isoprenaline), thereby demonstrating a stimulus-induced increase in miR-221/222 in vivo by angiotensin II but not by isoprenaline. +lncRNA target 31312375 hsa-mir-9 Cicatrix, Hypertrophic Samples of HS tissue and normal tissue were isolated from 20 patients, and the fibroblasts were transfected with small-interfering RNA (siRNA) for transforming growth factor beta 1 (TGF-beta1), miR-9 mimic, and miR-9 inhibition. +other 31312371 hsa-mir-143 Coronary Disease 3p was up-regulated in rabbit CHD model. +lncRNA target 31312355 hsa-mir-495 Carcinoma, Hepatocellular Conclusively, our data revealed that ZNF503 promoted migration, invasion and EMT process through regulating GATA3 expression, which was regulated by miR-495, suggesting the potential therapeutic value for HCC. +genetics_overexpression_promote 31312352 hsa-mir-9 Leukemia, Myeloid, Acute The suppressive effects of miR-9 on AML cells were counteracted or mimicked by CXCR4 overexpression or depletion, respectively. +other 31312211 hsa-mir-1 Sjogren's Syndrome The interaction network of differentially expressed circRNAs and microRNAs (miRNAs) was constructed and showed that miR-2008 and miR-31, detected with significantly differential expression in SUS-affected samples in a previous study, were predicted to be regulated by 10 and 11 differentially expressed circRNAs with more than 10 binding sites, respectively. +other 31312211 hsa-mir-2008 Sjogren's Syndrome The interaction network of differentially expressed circRNAs and microRNAs (miRNAs) was constructed and showed that miR-2008 and miR-31, detected with significantly differential expression in SUS-affected samples in a previous study, were predicted to be regulated by 10 and 11 differentially expressed circRNAs with more than 10 binding sites, respectively. +transcription factor target 31312141 hsa-mir-519b Colorectal Neoplasms Notably, the miR-519b-3p suppressed the uMtCK/Wnt signaling pathway in CRC cells, thereby suppressing CRC cell proliferation and invasion. +circulation_biomarker_diagnosis_up 31311940 hsa-mir-146b Acquired Immunodeficiency Syndrome Here, we show that miR-146b-5p is upregulated in both CD4 T cells, CD4 T cell-derived EVs and circulating EVs obtained from antiretroviral therapy-naive HIVinfected patients. +genetics_overexpression_promote 31311830 hsa-mir-326 Breast Neoplasms Overexpression of SOX12 partially rescued the inhibitory effect on cell proliferation, migration and invasion in breast cancer cells caused by miR-326 overexpression. +other 31311829 hsa-mir-143 Carcinoma, Pancreatic Ductal miR-135b, miR-221, miR-21, miR-27a, miR-199b-5p, miR-143, miR-196a, miR-655, miR3p, miR-744 and hub genes predicted poor OS of PDAC. +other 31311829 hsa-mir-199b Carcinoma, Pancreatic Ductal miR-135b, miR-221, miR-21, miR-27a, miR-199b-5p, miR-143, miR-196a, miR-655, miR3p, miR-744 and hub genes predicted poor OS of PDAC. +other 31311829 hsa-mir-744 Carcinoma, Pancreatic Ductal miR-135b, miR-221, miR-21, miR-27a, miR-199b-5p, miR-143, miR-196a, miR-655, miR3p, miR-744 and hub genes predicted poor OS of PDAC. +other 31311829 hsa-mir-196a Carcinoma, Pancreatic Ductal miR-135b, miR-221, miR-21, miR-27a, miR-199b-5p, miR-143, miR-196a, miR-655, miR3p, miR-744 and hub genes predicted poor OS of PDAC. +other 31311829 hsa-mir-21 Carcinoma, Pancreatic Ductal miR-135b, miR-221, miR-21, miR-27a, miR-199b-5p, miR-143, miR-196a, miR-655, miR3p, miR-744 and hub genes predicted poor OS of PDAC. +other 31311829 hsa-mir-27a Carcinoma, Pancreatic Ductal miR-135b, miR-221, miR-21, miR-27a, miR-199b-5p, miR-143, miR-196a, miR-655, miR3p, miR-744 and hub genes predicted poor OS of PDAC. +other 31311829 hsa-mir-455 Carcinoma, Pancreatic Ductal miR-135b, miR-221, miR-21, miR-27a, miR-199b-5p, miR-143, miR-196a, miR-655, miR3p, miR-744 and hub genes predicted poor OS of PDAC. +circRNA target 31311824 hsa-mir-335 Ischemic Stroke 3p sponge to inhibit miR +circRNA target 31311824 hsa-mir-335 Brain Injuries 3p sponge to inhibit miR +other 31311811 hsa-mir-194 Colorectal Neoplasms In summary, MALAT1 with the rs664589 G allele demonstrates altered binding to miR5p in the nucleus, leading to increased MALAT1 expression and enhanced colorectal cancer development. +lncRNA target 31311505 hsa-mir-885 Pancreatic Carcinoma MiRNA functional analysis in combination with Kaplan-Meier survival analysis suggest that hsa-miR5p could act as a tumor suppressor and should be validated as a potential prognostic biomarker in pancreatic cancer. +other 31311397 hsa-mir-223 Thyroid Neoplasms To investigate the effect of miR-223 on thyroid cancer cells, further to study its potential mechanisms. The difference in miR-223 expression between normal thyroid Nthy-ori3-l cells and thyroid cancer SW579 cells was detected by PCR. +transcription factor target 31311339 hsa-mir-122 Lipidoses BACKGROUND: Accumulating evidence showed that the expression of miR-122 was abnormal in NAFLD patients; however, the role of miR-122 on lipid accumulation and inflammation in NAFLD is not clear. The protective mechanism of miR-122 inhibition in NAFLD must be explored in future studies. +transcription factor target 31311339 hsa-mir-122 Non-alcoholic Fatty Liver Disease BACKGROUND: Accumulating evidence showed that the expression of miR-122 was abnormal in NAFLD patients; however, the role of miR-122 on lipid accumulation and inflammation in NAFLD is not clear. The protective mechanism of miR-122 inhibition in NAFLD must be explored in future studies. +transcription factor target 31311339 hsa-mir-122 Inflammation BACKGROUND: Accumulating evidence showed that the expression of miR-122 was abnormal in NAFLD patients; however, the role of miR-122 on lipid accumulation and inflammation in NAFLD is not clear. The protective mechanism of miR-122 inhibition in NAFLD must be explored in future studies. +other 31311255 hsa-mir-223 Spinal Cord Injuries OBJECTIVE: To assess the role of miRNA-21 and miRNA-223 in a balloon-compression model of spinal cord injury (SCI). CONCLUSION: Expression levels of miRNA-21 and miRNA-223 might be associated with the severity and acute phase of SCI, respectively. +other 31311255 hsa-mir-21 Spinal Cord Injuries OBJECTIVE: To assess the role of miRNA-21 and miRNA-223 in a balloon-compression model of spinal cord injury (SCI). CONCLUSION: Expression levels of miRNA-21 and miRNA-223 might be associated with the severity and acute phase of SCI, respectively. +genetics_GWAS 31310795 hsa-mir-15b Ovarian Failure, Premature It elucidated the underlying epigenetic regulatory mechanism, whereby cyclophosphamide-dependent microRNA-15b inhibited Kl expression, leading to the reduced ability of mOGCs to induce autophagy and ROS scavenging, ultimately causing POF. +lncRNA target 31310753 hsa-mir-299 Carcinoma, Renal Cell These results indicate that sh-TUG1 inhibited renal cell carcinoma formation by miR3p/VEGF axis in vitro and in vivo. +lncRNA target 31310393 hsa-mir-141 Carcinoma, Hepatocellular These finding suggested that SNHG15 promoted HCC progression via negative regulation of miR +genetics_overexpression_promote 31310382 hsa-mir-140 Prostatic Neoplasms The results showed that miR-140 was downregulated in PCa cells and tissues, and overexpression of miR-140 could significantly suppress their capacities of proliferation, migration, and invasion. +other 31310330 hsa-mir-21 Hypopharyngeal Neoplasms The miR-21/miR-375 ratio, which previously has been linked to tumor aggressiveness, was found to be >260-fold and >30-fold higher, respectively, in bile(+) HSCCs compared with their ANTs and bile(-) tumors. +other 31310330 hsa-mir-375 Hypopharyngeal Neoplasms The miR-21/miR-375 ratio, which previously has been linked to tumor aggressiveness, was found to be >260-fold and >30-fold higher, respectively, in bile(+) HSCCs compared with their ANTs and bile(-) tumors. +other 31310330 hsa-mir-375 Laryngopharyngeal Neoplasms The miR-21/miR-375 ratio, which previously has been linked to tumor aggressiveness, was found to be >260-fold and >30-fold higher, respectively, in bile(+) HSCCs compared with their ANTs and bile(-) tumors. +other 31310330 hsa-mir-21 Laryngopharyngeal Neoplasms The miR-21/miR-375 ratio, which previously has been linked to tumor aggressiveness, was found to be >260-fold and >30-fold higher, respectively, in bile(+) HSCCs compared with their ANTs and bile(-) tumors. +genetics_knock down_promote 31310241 hsa-mir-218 Triple Negative Breast Neoplasms Overexpression of ZFX reversed the tumor-suppressive effects of miR-218 on TNBC cell proliferation, migration, and invasion. +lncRNA target 31310159 hsa-mir-4513 Stomach Neoplasms Collectively, we showed that miR-4513 is involved in regulating the biological function of GC cells via KAT6B. +circulation_biomarker_diagnosis_ns 31310058 hsa-mir-371a Testicular Germ Cell Tumor BACKGROUND: The microRNAs of the miR3 cluster are novel serum markers for testicular germ cell tumors. +circulation_biomarker_diagnosis_ns 31310058 hsa-mir-371a Neoplasms, Germ Cell and Embryonal RESULTS: The seminal plasma miR-371a-3p levels of germ cell tumors patients were not different from controls. +other 31310058 hsa-mir-371a Infertility, Male CONCLUSION: The miR-371a-3p levels in ejaculate could represent a novel biomarker for the non-invasive evaluation of male infertility. +lncRNA target 31310044 hsa-mir-496 Glioma CEPB3 and miR-496 involved in HCG11-mediated glioma progression. CONCLUSIONS: HCG11 inhibited glioma progression by regulating miR-496/CPEB3 axis. +other 31309742 hsa-mir-125b Scleroderma, Systemic CONCLUSION: Our findings indicate that miR-125b is down-regulated in SSc skin and primary dermal fibroblasts. +genetics_knock down_suppress 31309567 hsa-mir-95 Stomach Neoplasms Together these results, miR-95 knockdown inhibited GC development via DUSP5-dependent MAPK pathway. +other 31309477 hsa-mir-210 Lung Neoplasms Particularly, we have selected a complementary hybridization DNA/RNA assay for the assessment of two miRNAs (miRNA-210 and miRNA-205) for detection of lung cancer. +other 31309477 hsa-mir-205 Lung Neoplasms Particularly, we have selected a complementary hybridization DNA/RNA assay for the assessment of two miRNAs (miRNA-210 and miRNA-205) for detection of lung cancer. +other 31309444 hsa-mir-429 Spinal Cord Injuries lncRNA Mirt2 exerts protective effects in an in vitro model of SCI by down-regulating miR-429. +transcription factor target 31309116 hsa-mir-557 Parkinson Disease This study aimed to screen the target miRNAs and to investigate the differential miR-3557/324-targeted signal mechanisms in the rats' model of Parkinson's disease (PD) with regular aerobic exercise. +other 31309116 hsa-mir-24 Parkinson Disease Screening from miRNA microarray chip, we further found upregulation of miR-3557 and downregulation of miR-324 were closely related to the calcium-modulating signaling pathway, remitting the progress of Parkinson's disease on aerobic exercise. +other 31309102 hsa-mir-98 Delayed Graft Function Three coexpressed miRNAs, hsa-miR-33a-5p_R-1, hsa-miR5p, and hsa-miR-151a-5p, were observed to be significantly upregulated in kidney recipients with DGF. +other 31309102 hsa-mir-151a Delayed Graft Function Three coexpressed miRNAs, hsa-miR-33a-5p_R-1, hsa-miR5p, and hsa-miR-151a-5p, were observed to be significantly upregulated in kidney recipients with DGF. +other 31309102 hsa-mir-33a Delayed Graft Function Three coexpressed miRNAs, hsa-miR-33a-5p_R-1, hsa-miR5p, and hsa-miR-151a-5p, were observed to be significantly upregulated in kidney recipients with DGF. +transcription factor target 31308851 hsa-mir-5195 Triple Negative Breast Neoplasms 3p might be a potential therapeutic target to reverse chemoresistance in TNBC through its targeting of EIF4A2. +other 31308756 hsa-mir-542 Endometrial Neoplasms Hsa-miR3p and hsa-let-7c-5p were downregulated in the grade 3 EC validated by qRT-PCR analysis. +other 31308756 hsa-let-7c Endometrial Neoplasms Hsa-miR3p and hsa-let-7c-5p were downregulated in the grade 3 EC validated by qRT-PCR analysis. +lncRNA target 31308265 hsa-mir-508 Colorectal Neoplasms 3p/PARD3/autophagy pathway play a critical role in CRC cell proliferation, and might provide novel targets for developing therapeutic strategies for CRC. +circulation_biomarker_diagnosis_up 31308028 hsa-mir-21 Breast Neoplasms RESULTS: (1) The serum levels of carcinoembryonic antigen (CEA)and carbohydrate antigen 15-3 (CA15-3) in the breast cancer group were higher than those in the healthy controls and patients with benign breast lesions; (2) The expression level of let-7a-5p in the serum of the breast cancer group was lower than that in the healthy control group (P<0.05), but there was no significant difference compared to the breast benign lesion group (P>0.05); (3) The serum expression level of miR +circulation_biomarker_diagnosis_up 31308028 hsa-let-7a Breast Neoplasms RESULTS: (1) The serum levels of carcinoembryonic antigen (CEA)and carbohydrate antigen 15-3 (CA15-3) in the breast cancer group were higher than those in the healthy controls and patients with benign breast lesions; (2) The expression level of let-7a-5p in the serum of the breast cancer group was lower than that in the healthy control group (P<0.05), but there was no significant difference compared to the breast benign lesion group (P>0.05); (3) The serum expression level of miR +exosome 31307515 hsa-mir-501 Carcinoma, Pancreatic Ductal Both M2 macrophage-derived exosomes and miR +other 31307429 hsa-mir-146a Thyroid Cancer, Papillary Comparing PTC and control groups before surgery showed a significant difference (P = 0.01), while no significant difference was observed comparing them after surgery, in miR146-a (P = 0.27). +lncRNA target 31307392 hsa-let-7 Hyperostosis, Diffuse Idiopathic Skeletal Analysis of the let-7 and linfamily heterochronic targets, lin-28 and hbl-1, showed that both genes were significantly downregulated in pry-1 mutants, and furthermore, lin-28 silencing reduced the number of seam cells in mutant animals. +genetics_knock down_promote 31307201 hsa-mir-135a Nasopharyngeal Carcinoma Moreover, knockdown of ZFAS1 or addition of miR-135a inhibited cell proliferation, migration and invasion but promoted apoptosis in NPC cells. +other 31307199 hsa-mir-375 Stomach Neoplasms PAX6 axis may represent a new regulatory network that should be further investigated, and the results of this study provide a better understanding of GC. +other 31307184 hsa-mir-152 Glomerulonephritis, IGA CONCLUSIONS: The expression of urinary miR5p is positively correlated with IgA nephropathy, which provides a new way for early diagnosis and treatment of IgA nephropathy with elevated proteinuria. +circulation_biomarker_prognosis_ns 31307177 hsa-mir-221 Prostatic Neoplasms CONCLUSIONS: The potentials of circulating miR-21, miR-221, and PHI serum level as biomarkers for PC have been established not only as diagnostic factors but also as prognostic markers. +other 31307177 hsa-mir-21 Prostatic Neoplasms Our results showed that adding miR-21 to PHI for detecting patients with LPC, increased the sensitivity to 95.5% at a specificity 100% (p < 0.0001). +circulation_biomarker_diagnosis_ns 31307174 hsa-mir-599 Ischemic Stroke BACKGROUND: The current study aims to investigate the expression of miR-599 in serum of patients with ischemic stroke and its correlation with high sensitivity C-reactive protein (hs-CRP) and matrix metalloproteinase-9 (MMP-9). CONCLUSIONS: Serum miR-599 may be used as a molecular marker in the diagnosis of ischemic stroke and may play an important role in the pathogenesis and development of ischemic stroke in cooperation with hs-CRP and MMP-9. +circulation_biomarker_diagnosis_ns 31307169 hsa-mir-587 Metabolic Diseases CONCLUSIONS: In summary the decreased expression of miR-587 in serum is a potential diagnostic marker and in-dependent risk factor in patients with MS. +genetics_GWAS 31307168 hsa-mir-499 Atrial Fibrillation CONCLUSIONS: Our data support that the pre-miR-499 T/C (rs3746444) polymorphism is associated with AF, and the C allele has increased risk for AF in Han Chinese. +genetics_GWAS 31307168 hsa-mir-499c Atrial Fibrillation CONCLUSIONS: Our data support that the pre-miR-499 T/C (rs3746444) polymorphism is associated with AF, and the C allele has increased risk for AF in Han Chinese. +circulation_biomarker_diagnosis_ns 31307166 hsa-mir-1 Mucocutaneous Lymph Node Syndrome CONCLUSIONS: In summary, serum miR-1 in patients with acute KD was significantly increased, which may be one of the potential serum markers for the diagnosis of KD. +circulation_biomarker_diagnosis_ns 31307166 hsa-mir-1 Leukemia, Myeloid, Acute CONCLUSIONS: In summary, serum miR-1 in patients with acute KD was significantly increased, which may be one of the potential serum markers for the diagnosis of KD. +lncRNA target 31306911 hsa-mir-1307 Foot-and-Mouth Disease Together, our data demonstrated that miR-1307 suppresses FMDV replication by destabilizing VP3 and enhancing host immune response. +lncRNA target 31306653 hsa-mir-195 Carcinoma, Hepatocellular miR-195 expression was significantly decreased in HCC tissues and negatively correlated with SNHG16 expression. In conclusion, our findings reported that the oncogenic role of SNHG16 in HCC tumorigenesis through a novel SNHG16-miR-195 axis, which provided a novel insight for HCC and helped to probe a potential therapeutic target for the deadly disease. +genetics_overexpression_promote 31306637 hsa-mir-340 Leukemia, Myeloid, Acute 5p overexpression-mediated inhibitory effect on AML cell growth. +circulation_biomarker_prognosis_up 31306108 hsa-mir-150 Colorectal Neoplasms Collectively, serum exosomal miR +other 31306106 hsa-mir-153 Lung Neoplasms OBJECTIVE: Present study aims to investigate the roles and underlying mechanism of miR-153 in modulating gefitinib resistance in lung cancers. CONCLUSIONS: MiR-153 regulates gefitinib resistance by modulating expression of ABCE1 in lung cancers. +circulation_biomarker_prognosis_ns 31306104 hsa-mir-1290 Esophageal Squamous Cell Carcinoma CONCLUSIONS: The level of serum microRNA-1290 in ESCC patients increased significantly, and its expression level could reflect the progress of ESCC, suggesting that serum microRNA-1290 might be a useful diagnostic and prognostic marker of ESCC. +other 31305134 hsa-mir-4530 Abortion, Habitual This study identified several genes and miRNAs involved in the development and progression of URSA, including FCGR1A, FCGR3A, CXCL8, HCK, PLEK, IL10, hsa-miR-498, and hsa-miR-4530. +genetics_overexpression_promote 31305122 hsa-mir-34a Colorectal Neoplasms Overexpression of ADAM10 reverted both miR-34a and sevoflurane-induced repression in the cell proliferation, migration and invasion abilities of CRC cells. +other 31304868 hsa-mir-4470 Dehydration Our study demonstrates that the T allele of rs13079080 in SUCNR1 disrupts a binding site for miRNA-4470, potentially increasing SUCNR1 expression and consequently increasing the capacity of sensing and dealing with oxidative stress. +circRNA target 31304776 hsa-mir-326 Glioma Conclusion: circ_000173 promoted growth and invasion in glioblastoma cells via the miR-326/Wnt7B axis. +genetics_overexpression_promote 31304680 hsa-mir-338 Thyroid Neoplasms NR2F1-AS1 and CCND1 were overexpressed, whereas miRNA +genetics_GWAS 31304631 hsa-mir-124 Down Syndrome Here, we show that Down syndrome critical region 1 (DSCR1) protein plays a key role in adult hippocampal neurogenesis by modulating two epigenetic factors: TET1 and miR-124. +genetics_overexpression_promote 31303644 hsa-mir-4268 Stomach Neoplasms Notably, silencing Rab6B resulted in the same biological effects in GC cells as those induced by overexpression of miR-4268. +transcription factor target 31303496 hsa-mir-23b Colorectal Neoplasms In addition, miR-23b and BTBD7 correlate with CRC metastasis both in preclinical experiments and in clinical samples. Finally, both Btbd7 and miR-23b represent promising prognostic biomarkers and therapeutic targets in CRC. +lncRNA target 31303129 hsa-mir-29a Colorectal Neoplasms The findings demonstrate miR-29a-3p inhibits CRC cell function possibly by targeting RPS15A, which might be exploited therapeutically in CRC. +transcription factor target 31302420 hsa-mir-103 Osteoarthritis In summary, we demonstrated that miR-103 contributed to osteoarthritis development by directly targeting and inhibiting the expression of Sox6. +transcription factor target 31302329 hsa-mir-187 Acute Kidney Injury CONCLUSIONS: Our findings indicated that miR-187 improved I/R-induced ischemic acute renal failure through protecting glomerular filtration barrier by blocking the expression of ACHE. +other 31302227 hsa-mir-21 Diabetes Mellitus In this study, we found the direct delivery of HEKa-MVs expressing miR-21 mimics significantly promoted the healing of skin wound in diabetic rats. Thus, our study has provided for the first time the basis for the potential application of HEKa-MVs, and MV miR-21 in particular for wound healing. +circulation_biomarker_diagnosis_up 31302118 hsa-mir-1976 Sick Sinus Syndrome First, using microarray-based miRNA expression profiling and qRT-PCR, we confirmed that miR-1976 was upregulated in the plasma of patients with age-related SSS relative to healthy controls. +lncRNA target 31301902 hsa-mir-191 Adenocarcinoma of Lung Metastasis-associated lung adenocarcinoma transcript 1 positively regulated the expression of human antigen R through sponging miR +lncRNA target 31301414 hsa-mir-125a Ovarian Neoplasms Therefore, the present study aimed to investigate the effects of LAMC2 in ovarian cancer progression and determine whether LAMC2 expression is under the regulation of miR-125a-5p or miR-193a-3p in ovarian cancer. SIGNIFICANCE: The present study clarified that LAMC2 functioned as an oncogene in ovarian cancer through upregulating p38 under the regulation of miR-125a-5p. +lncRNA target 31301310 hsa-let-7f-1 Autolysis FOXO1 inhibition by small-molecule drug partially attenuated the increase in smoke-exposed HSAEC and HPAEpiC apoptosis, cytolysis and the decrease in cell viability caused by Let-7f +transcription factor target 31301305 hsa-mir-20a Osteoporosis, Postmenopausal CONCLUSIONS: Our outcomes demonstrated that miR-320a promoted MC3T3-E1 cells apoptosis, suppressed MC3T3-E1 cells viability and differentiation through targeting MAP9 and modulating PI3K/AKT signaling pathway, which provided theoretical support for miR-320a/MAP9 as promising targets for the treatment and prevention of PMO. +genetics_knock down_promote 31301273 hsa-mir-137 Parkinson Disease Loss-of-function experiments using miR-137 antagomir exhibited that inhibition of exosomal miR-137 ameliorated PD-induced oxidative stress injury in vitro, reduced pole-climbing time but increased score for traction test in vivo. +lncRNA target 31301111 hsa-mir-125b Vascular Diseases We further provide a computational biologic presentation of the complex network of miR-125b and its target genes within the scope of vascular diseases. +circulation_biomarker_diagnosis_ns 31301104 hsa-mir-125b Sepsis Blood samples within 24 hours after admission of sepsis patients and those on enrollment of HCs were collected, and then, plasma was separated for lncRNA MALAT1 and miR-125b expressions detections by RT-qPCR. Moreover, lncRNA MALAT1 expression was negatively correlated with miR-125b level in both sepsis patients (P < 0.001) and HCs (P < 0.001). +lncRNA target 31300734 hsa-mir-210 Hypoxia-Ischemia, Brain, Newborn "MicroRNA-210 (miR-210) is the master ""hypoxamir"" and plays a key role in hypoxic-ischemic tissue damage. Thus, our study identified miR-210 as a novel regulator of microglial activation in neonatal HIE, highlighting a potential therapeutic target in the treatment of infants with hypoxic-ischemic brain injury." +genetics_knock down_promote 31300733 hsa-mir-597 Colorectal Neoplasms 5p could significantly attenuate the biological effects of circ101555 knockdown on CRC cells. +exosome 31300703 hsa-mir-223 Panniculitis, Peritoneal Here, we recorded microRNA profiles in the PD effluent of patients presenting with symptoms of acute peritonitis and show that elevated peritoneal miR-223 and reduced miR-31 levels were useful predictors of bacterial infection. miR-223 was found to be functionally stabilised in PD effluent from peritonitis patients, with a proportion likely to be incorporated into neutrophil-derived exosomes. +other 31300703 hsa-mir-1 Panniculitis, Peritoneal Here, we recorded microRNA profiles in the PD effluent of patients presenting with symptoms of acute peritonitis and show that elevated peritoneal miR-223 and reduced miR-31 levels were useful predictors of bacterial infection. +circulation_biomarker_prognosis_up 31300482 hsa-mir-106b Breast Neoplasms IMPLICATIONS FOR PRACTICE: In order to enhance the prognostic accuracy of the circulating tumor cell (CTC) phenotype in patients with metastatic breast cancer (MBC), this study screened and identified a CTC-specific microRNA (miRNA), miR-106b, as an upregulated molecule based on the comparison of miRNA profile between CTCs, primary tumors, and healthy blood donors. +other 31300015 hsa-mir-5582 Breast Neoplasms LUCAT1 increased stem-like properties of BCCs and stemness of BCSCs by competitively binding miR3p with TCF7L2 and enhancing the Wnt/beta-catenin pathway. +transcription factor target 31299862 hsa-mir-539 Lung Neoplasms The anti-tumour properties of lidocaine towards A549 and NCI-H1299 cells were partially attenuated when miR-539 was silenced. The anti-tumour properties of lidocaine may be partial via up-regulation of miR-539, which blocked EGFR signalling by directly binding with EGFR. +genetics_overexpression_promote 31299308 hsa-mir-103a Pituitary Neoplasms Additionally, rno-miR-103a-3p overexpression suppressed rat pituitary adenoma cell proliferation, induced cell apoptosis, arrested cell cycle in the G/S phase, reduced GH and PLR secretion, and inhibited the PI3K/AKT signaling pathway. +other 31299195 hsa-mir-21 Epstein-Barr Virus Infections Reportedly, EBV infection induces the expression of specific cellular microRNAs (miRNAs), such as miR-155, miR-146a, miR-21, which can contribute to the persistence of latently infected cells. +other 31299195 hsa-mir-155 Epstein-Barr Virus Infections Reportedly, EBV infection induces the expression of specific cellular microRNAs (miRNAs), such as miR-155, miR-146a, miR-21, which can contribute to the persistence of latently infected cells. +other 31299195 hsa-mir-146a Epstein-Barr Virus Infections Our findings indicate that LMP1-miR-146a-CXCR4 axis functions as a regulator in the EBV-associated cells. +lncRNA target 31299165 hsa-mir-196b Carcinoma, Hepatocellular Moreover, our data showed that miR-196b-5p inhibited the expression of WIPF2 in HCC, illustrating a regulatory axis of RP5-1120P11.3-miR-196b-5p-WIPF2 that facilitated the progression of HCC. These findings suggested that the RP5-1120P11.3-miR-196b-5p-WIPF2 axis is a potential target for treatment of HCC. +lncRNA target 31299041 hsa-mir-381 Carcinoma, Renal Cell CONCLUSIONS miR-381 levels were significantly downregulated in renal cancer tissues and miR-381 inhibition promoted tumor cell growth, migration, and chemoresistance. +genetics_overexpression_promote 31298493 hsa-mir-539 Prostatic Neoplasms In conclusion, the overexpression of miR +lncRNA target 31298469 hsa-mir-346 Carcinoma, Renal Cell NBAT1 functioned as an endogenous sponge by competing for miR-346 binding to GSK-3beta and therefore alleviated RCC cells. +genetics_overexpression_promote 31298412 hsa-mir-296 Esophageal Squamous Cell Carcinoma The overexpression of miR +transcription factor target 31298411 hsa-mir-451a Carcinoma, Hepatocellular Our findings indicated that miR-451a could serve as a novel target for HCC diagnosis and biological therapy. +other 31298399 hsa-mir-185 Diabetes Mellitus, Type 2 CONCLUSIONS: Our data demonstrated that LncRNA MEG3 aggravated palmitate-induced insulin resistance by regulating miR5p/Egr2 axis, providing new insights into T2D therapeutic strategies. +lncRNA target 31298396 hsa-mir-1 Asthma CONCLUSIONS: MiR-26a, miR-146a, and miR-31 are involved in asthma progression mainly through regulating inflammatory factors and cells. +lncRNA target 31298396 hsa-mir-26a Asthma CONCLUSIONS: MiR-26a, miR-146a, and miR-31 are involved in asthma progression mainly through regulating inflammatory factors and cells. +lncRNA target 31298396 hsa-mir-146a Asthma CONCLUSIONS: MiR-26a, miR-146a, and miR-31 are involved in asthma progression mainly through regulating inflammatory factors and cells. +lncRNA target 31298392 hsa-mir-22 Carcinoma, Hepatocellular In addition, rescue experiments demonstrated that lncRNA H19 remarkably promoted malignant development of HBV-related HCC via regulating microRNA-22. CONCLUSIONS: LncRNA H19 promotes malignant development of HBV-related HCC through regulating microRNA-22 via EMT pathway. +lncRNA target 31298387 hsa-mir-34b Leukemia, Myeloid, Acute Rescue experiments were conducted to verify whether microRNA-34b could regulate proliferative and apoptotic behaviors of leukemia cells by suppressing LDHA expression. +transcription factor target 31298385 hsa-mir-22 Melanoma CONCLUSIONS: Our findings showed that miR-22 served as a tumor suppressor in melanoma progression, implying that miR-22 may function as a novel therapeutic target and prognostic biomarker for melanoma treatments. +lncRNA target 31298384 hsa-mir-4486 Glioma CONCLUSIONS: We identified the functional mechanism by which SNHG20 modulated the malignancy of glioma cells via targeting the miR-4486/MDM2/p53 pathway. +lncRNA target 31298381 hsa-mir-140 Breast Neoplasms CONCLUSIONS: TATDN1 promotes the proliferative potential and cell cycle progression of BCa cells through adsorbing microRNA +lncRNA target 31298380 hsa-mir-7 Breast Neoplasms OBJECTIVE: To explore whether micro ribonucleic acid (miR)-7 affects the resistance of breast cancer cells to adriamycin (ADR) through regulating the epidermal growth factor receptor (EGFR)/phosphatidylinositol 3-hydroxy kinase (PI3K) signaling pathway. CONCLUSIONS: MiR-7 plays an important role in the resistance of breast cancer cells to ADR, and its over-expression can inhibit the EGFR/PI3K signaling pathway to raise their sensitivity to the chemotherapy drug ADR. +lncRNA target 31298378 hsa-mir-373 Squamous Cell Carcinoma of Head and Neck MiR-373/SPOP axis could be a potential therapeutic target for OSCC. +lncRNA target 31298377 hsa-mir-16 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: The present study demonstrates that miR-16 acts as a tumor-suppressor gene by inhibiting the proliferation, migration, and invasion of NSCLC cells via downregulating MMP-19 expression. +circulation_biomarker_prognosis_up 31298376 hsa-mir-25 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: Collectively, our findings demonstrated that the plasma miR-25 might serve as a novel promising biomarker in the diagnosis and prognosis prediction of NSCLC. +other 31298375 hsa-mir-124 Lung Neoplasms OBJECTIVE: To investigate the role of micro ribonucleic acid (miR)-124 in drug resistance of non-small cell lung cancer (NSCLC), and to explore its underlying mechanism. CONCLUSIONS: MiR-124 regulates the sensitivity of NSCLC to cisplatin. +lncRNA target 31298374 hsa-mir-875 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: MiR-875 may regulate the proliferation and apoptosis of NSCLC cells via targeting SOCS2, suggesting that miR-875 has the potential to become a therapeutic target for the treatment in NSCLC. +genetics_overexpression_promote 31298369 hsa-mir-378 Stomach Neoplasms MiR-378 overexpression repressed GC cell invasion, migration and EMT. +genetics_overexpression_suppress 31298368 hsa-mir-1179 Carcinoma, Hepatocellular The overexpression of ZEB2 reversed the inhibitory effects of miRNA-1179 on the proliferative and migratory abilities in HCC cells. +lncRNA target 31298367 hsa-mir-28 Urinary Bladder Neoplasms 3p inhibited tumorigenesis of BC through targeting ITGA5 and inactivating the PI3K/AKT pathway. +genetics_GWAS 31298366 hsa-mir-506 Prostatic Neoplasms Overexpression of GALNT4 reversed the tumor-suppressive effects of miR +lncRNA target 31298364 hsa-mir-93 Uterine Cervical Neoplasms 5p might be a potential therapeutic target for the treatment of CC. +other 31298363 hsa-mir-25 Ovarian Neoplasms CONCLUSIONS: PG exhibited anti-cancer activity in ovarian cancer by downregulating miR-25. +lncRNA target 31298359 hsa-mir-9 Osteoarthritis OBJECTIVE: To explore the effect of micro ribonucleic acid (miR-9) on cartilage regeneration of osteoarthritis in rabbits through the regulation of the Notch signaling pathway. MATERIALS AND METHODS: A total of 30 specific pathogen-free Sprague-Dawley rabbits were randomly divided into control group (healthy rabbits, n=10), model group (osteoarthritis model, n=10) and miR-9 group (osteoarthritis model miR-9 interference, n=10). +transcription factor target 31298353 hsa-mir-296 Carcinoma, Non-Small-Cell Lung 3p can regulate the migration and invasion of A549 cells via targeting RABL3. +lncRNA target 31298352 hsa-mir-760 Colorectal Neoplasms Furthermore, functional assays revealed that miR-760 restoration obviously suppressed CRC cell proliferation, migration and invasion through modulating phosphatidylinositol 3-kinase/ protein kinase B (PI3K/AKT) pathway and epithelial-mesenchymal transition (EMT). +circulation_biomarker_diagnosis_ns 31298342 hsa-mir-200c Diabetic Nephropathies CONCLUSIONS: LncRNA TCF7 triggered endoplasmic reticulum stress through a sponge action with miR-200c in patients with diabetic nephropathy. +genetics_knock down_promote 31298340 hsa-mir-488 Leukemia, Myeloid, Acute Knockdown of SNHG1 markedly upregulated the miR +lncRNA target 31298339 hsa-mir-485 Glioma 5p inhibition reverses the suppressive impacts of MFI2-AS1 silencing on the growth, migration, and invasive abilities of glioma cells. +genetics_overexpression_promote 31298337 hsa-mir-1 Thyroid Cancer, Papillary Moreover, functional assays indicated that miR-31 overexpression could notably repress PTC cell proliferation, invasion and migration abilities by regulating the extracellular regulated protein kinases (ERK) and protein kinase B (Akt) signaling pathways and epithelial-mesenchymal transition (EMT). +lncRNA target 31298336 hsa-mir-24 Thyroid Cancer, Papillary CONCLUSIONS: MIR22HG inhibited cell growth through modulating p27kip1 by decreasing miR +other 31298334 hsa-mir-145 Carcinoma, Non-Small-Cell Lung OBJECTIVE: The aim of this study was to investigate the role of micro-ribonucleic acid (miR)-145 in acquired resistance of non-small cell lung cancer (NSCLC) to gefitinib, and to explore its potential mechanism. +lncRNA target 31298332 hsa-mir-370 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: The interference of FAM201A impairs its suppression of miR-370, resulting in the upregulation of EGFR and HIF-1alpha and enhancement of radiosensitivity in NSCLC patients. +genetics_knock down_promote 31298329 hsa-mir-761 Squamous Cell Carcinoma of Head and Neck Lowly expressed microRNA-761 reversed the inhibitory effect of lncRNA FAL1 knockdown on the proliferative potential of OSCC cells. +genetics_overexpression_promote 31298326 hsa-mir-34a Colonic Neoplasms Besides, luciferase reporter gene assay revealed that overexpression of miR-34a significantly attenuated the luciferase activity of the wild-type HOTAIR vector group without attenuating the mutant HOTAIR vector group (p>0.05) In addition, the recovery experiment also found a mutual regulation between HOTAIR and miR-34a, together they could affect the malignant progression of colon cancer. +genetics_overexpression_promote 31298325 hsa-mir-551b Colorectal Neoplasms Interesting observations revealed that the cells capacities were higher in miR-551b PTP4A3 group, when compared with those in miR-551b group, indicating that up-regulation of PTP4A3 rescued the repressive functions of miR-551b overexpression on CRC cells growth and migration. +other 31298324 hsa-mir-873 Colorectal Neoplasms Mechanistic studies showed that the up-regulation of DDX11-AS1 competitively bound to miR-873 prevented CLDN7 from miRNAs-mediated degradations, thus facilitated the CRC progress. +lncRNA target 31298318 hsa-mir-203 Prostatic Neoplasms Our findings revealed that miR-203/RGS17 axis might be a potential therapeutic target for the treatment of PCa. +genetics_overexpression_promote 31298317 hsa-mir-93 Carcinoma, Endometrioid Furthermore, the overexpression of microRNA +lncRNA target 31298316 hsa-mir-1271 Endometrial Neoplasms CCK-8 assay and colony formation assay indicated that over-expression of miR-1271 suppressed cell proliferation in EC. +lncRNA target 31298315 hsa-mir-215 Uterine Cervical Neoplasms Up-regulation of SOX9 reversed the suppressive impact of miR +genetics_overexpression_promote 31298314 hsa-mir-299 Uterine Cervical Neoplasms In addition, TCF4 overexpression reversed the inhibitory effects of miR +lncRNA target 31298311 hsa-mir-934 Ovarian Neoplasms MATERIALS AND METHODS: Human ovarian cancer cell lines HO8910 and OVCAR-3 were transfected with miR-934 inhibitor and corresponding negative control (inhibitor control). +lncRNA target 31298308 hsa-mir-181 Osteoarthritis CONCLUSIONS: The decrease of miR-181 can reduce the expressions of inflammatory factors TNF-alpha and IL-6 through downregulating the NF-kappaB signaling pathway, thus repressing the occurrence of OA. +genetics_overexpression_suppress 31298226 hsa-mir-1 Thyroid cancer, medullary RASA2, overexpressed in MTC, were negatively regulated by miR +lncRNA target 31298047 hsa-mir-326 Carcinoma, Hepatocellular Our findings suggest that miR-326 may be a candidate prognostic biomarker and a target for new therapies in HCC patients. +lncRNA target 31297980 hsa-mir-107 Stomach Neoplasms CONCLUSIONS: miR-107 promotes growth and metastasis in GC via activation of PI3K-AKT signaling by targeting FAT4, which may be a target for GC treatment. +genetics_overexpression_promote 31297892 hsa-mir-422a Retinoblastoma MiR-422a overexpression led to a decline of SKP2 expression and cell growth in RB. +genetics_overexpression_promote 31297886 hsa-mir-153 Ovarian Neoplasms MCL1 gene was found overexpressed in OVC tissues and OVC cell lines at RNA and protein levels, whereas miR +genetics_overexpression_promote 31297884 hsa-mir-933 Squamous Cell Carcinoma of Head and Neck hsa_circRNA_100533 inhibited cell proliferation, migration, and promoted cell apoptosis in OSCC cell lines, which could be blocked by hsa-miR-933 overexpression. +lncRNA target 31297882 hsa-mir-215 Carcinoma, Hepatocellular Subsequently, the in vivo results demonstrated that silence of LINC00152 restrained HCC development via modulating miR-215 to up-regulate CDK13. +lncRNA target 31297866 hsa-mir-18b Adenocarcinoma of Lung Finally, rescue assays confirmed that ZFPM2-AS1 could regulate LUAD cell proliferation via miR-18b-5p/VMA21 axis. +other 31297864 hsa-mir-126 pancreatic adenocarcinoma Four (hsa-mir-126, hsa-mir-3613, hsa-mir-424, and hsa-mir-4772) out of 17 differentially expressed miRNAs were associated to the OS of patients with PAAD. +other 31297864 hsa-mir-424 pancreatic adenocarcinoma Four (hsa-mir-126, hsa-mir-3613, hsa-mir-424, and hsa-mir-4772) out of 17 differentially expressed miRNAs were associated to the OS of patients with PAAD. +other 31297864 hsa-mir-613 pancreatic adenocarcinoma Four (hsa-mir-126, hsa-mir-3613, hsa-mir-424, and hsa-mir-4772) out of 17 differentially expressed miRNAs were associated to the OS of patients with PAAD. +other 31297864 hsa-mir-4772 pancreatic adenocarcinoma Four (hsa-mir-126, hsa-mir-3613, hsa-mir-424, and hsa-mir-4772) out of 17 differentially expressed miRNAs were associated to the OS of patients with PAAD. +transcription factor target 31297863 hsa-mir-181b Myocardial Ischemia Hence, our study indicates that miR-181b-5p is essential for MI/RI via regulation of PI3K/Akt signaling pathway and could be a potential therapeutic target in IHD. +genetics_overexpression_suppress 31297857 hsa-mir-376 Osteoarthritis Altogether, TNFSF10 overexpression probably stimulated proliferation and inflammation, and inhibited apoptosis by regulating the miR3p/FGFR1 axis, implying that its increase contributed to OA progression. +other 31297834 hsa-mir-34 Thyroid cancer, medullary Analysis of the results was performed by the 2 (-DeltaDeltaCt) method, showing that miR-144 and miR-34a expression had a relative increase in patients with MTC compared with normal control samples and also in RET positives versus RET negatives. +other 31297834 hsa-mir-144 Thyroid cancer, medullary Analysis of the results was performed by the 2 (-DeltaDeltaCt) method, showing that miR-144 and miR-34a expression had a relative increase in patients with MTC compared with normal control samples and also in RET positives versus RET negatives. +other 31297834 hsa-mir-34a Thyroid cancer, medullary Analysis of the results was performed by the 2 (-DeltaDeltaCt) method, showing that miR-144 and miR-34a expression had a relative increase in patients with MTC compared with normal control samples and also in RET positives versus RET negatives. +lncRNA target 31297133 hsa-mir-216a Esophageal Squamous Cell Carcinoma CONCLUSIONS: Our results demonstrate that miR-216a-5p might serve as a tumor suppressor in ESCC cells through negatively regulating TCTN1 expression, indicating the possibility that miR-216a-5p and TCTN1 might be attractive targets for ESCC therapeutic intervention. +other 31296962 hsa-mir-153 Neurodegenerative Diseases Overall, our findings revealed that miR-153 affected neurogenesis by regulating the Notch signaling pathway and elucidated the function of miR-153 in aging-related, hippocampus-dependent cognitive ability impairments, and neurodegenerative diseases. +transcription factor target 31296840 hsa-mir-199b Carcinoma, Non-Small-Cell Lung Taken together, LINC81507 is decreased in NSCLC and functions as a sponge to miR-199b-5p to regulate CAV1/STAT3 pathway, which suggests that LINC81507 serve as a tumor suppressor and potential therapeutic target and biomarker for metastasis and prognosis in NSCLC. +other 31296839 hsa-mir-577 high grade glioma Single or combined treatment of KHDRBS3, cDENND4C, and miR-577 effectively promoted antitumor drug doxorubicin (DOX) across BTB to induce apoptosis of glioma cells. +other 31296440 hsa-mir-17 Instent Restenosis The present study aims to investigate the potential roles of miR-17 in CHD. miR-17 may be a promising biomarker for CHD. +other 31296380 hsa-mir-34a Pain, Inflammatory However, the role of miR-34a/SIRT1 in complete Freund's adjuvant (CFA)-induced inflammatory pain remains unclear. Our data provide support that the underlying mechanisms of miR-34a in promoting inflammatory pain may involve negative regulation of SIRT1. +lncRNA target 31296175 hsa-mir-613 Adenocarcinoma of Lung The identified early EMT hallmark genes GALNT6, SPARC and HES7and miR-3613 provide new markers and therapeutic targets for LUAD for the further clinical diagnosis and drug screening. +genetics_knock down_promote 31296130 hsa-mir-367 Ischemic Stroke Results suggest that loss of miR3p suppression of GPRC5A may contribute to neuroinflammation associated with ischemic stroke. +lncRNA target 31296077 hsa-let-7 Sleep Apnea, Obstructive In another cohort of 12 OSAHS cases and 7 controls, the mRNA expression levels of interleukin (IL)-6 and Lin-28 homolog A (Lin28A), targets of the downregulated let-7 family members, were measured by real-time quantitative-PCR. +transcription factor target 31295851 hsa-mir-200b Triple Negative Breast Neoplasms Our studies showed the importance of therapeutic targeting ARRDC3/miR-200b pathway in TNBC. +genetics_GWAS 31295467 hsa-mir-34a Alzheimer Disease Collectively, these results indicate that a rapid, profound cognitive decline and Alzheimer's disease neuropathology can be induced with miR-34a over-expression, suggesting that this animal model may represent a polygenetic risk factor model for LOAD. +genetics_knock down_promote 31295229 hsa-mir-7 Colorectal Neoplasms 5p, and knockdown of it could inhibit tumor growth, migration, invasion, and induce apoptosis in CRC. +lncRNA target 31295021 hsa-mir-184 Inflammation The expression of miR-184 was significantly lower in inflamed corneas than in control ones, which suggested that cZNF609 might serve as a sponge for miR-184. The expression of heparanase, a potential target gene of miR-184, was significantly increased in inflamed corneas. +lncRNA target 31295021 hsa-mir-184 Keratitis The expression of miR-184 was significantly lower in inflamed corneas than in control ones, which suggested that cZNF609 might serve as a sponge for miR-184. The expression of heparanase, a potential target gene of miR-184, was significantly increased in inflamed corneas. +lncRNA target 31295012 hsa-mir-20a Cardiomegaly This study aims to identify the expression profile of microRNAs (miRNAs) in hypertrophic cardiomyopathy (HCM) and explore the function of miRNA-20 in inducing cardiomyocyte hypertrophy through regulating MFN2. +lncRNA target 31295012 hsa-mir-20a Cardiomyopathy, Hypertrophic This study aims to identify the expression profile of microRNAs (miRNAs) in hypertrophic cardiomyopathy (HCM) and explore the function of miRNA-20 in inducing cardiomyocyte hypertrophy through regulating MFN2. +lncRNA target 31295012 hsa-mir-20 Cardiomegaly This study aims to identify the expression profile of microRNAs (miRNAs) in hypertrophic cardiomyopathy (HCM) and explore the function of miRNA-20 in inducing cardiomyocyte hypertrophy through regulating MFN2. +lncRNA target 31295012 hsa-mir-20 Cardiomyopathy, Hypertrophic This study aims to identify the expression profile of microRNAs (miRNAs) in hypertrophic cardiomyopathy (HCM) and explore the function of miRNA-20 in inducing cardiomyocyte hypertrophy through regulating MFN2. +transcription factor target 31294899 hsa-mir-34a Carcinoma, Renal Cell Inhibition of miR-34a-5p can correct the p53-DAPK axis disruption by upregulating DAPK protein and may have potential to be used as a therapeutic target to improve outcomes for ccRCC patients. +other 31294463 hsa-mir-494 Urinary Bladder Neoplasms In conclusion, it was suggested MEG3 can interact with miR-494 to regulate PTEN in bladder cancer development. +other 31294459 hsa-mir-3 ST Elevation Myocardial Infarction These observations demonstrate the involvement of the miR33/SIRT1 pathway in the increased pro-inflammatory and pro-coagulable state of coronary thrombi in hyperglycemic STEMI patients. +genetics_overexpression_promote 31294443 hsa-mir-214 Breast Neoplasms The overexpression of miR-214 inhibited cell proliferation and invasion of breast cancer, while suppression of miR-214 by chemically modified antagomir enhanced the proliferation and invasion of breast cancer cells. +other 31294031 hsa-mir-146a Aortic Valve Stenosis In conclusion, in line with the acknowledged role of miR-146a in atherosclerotic inflammation, our data suggest it may be extended to the specific location of aortic valves in aortic stenosis. +lncRNA target 31293973 hsa-mir-100 Carcinoma, Hepatocellular The direct targets of miR-100 (such as IGF1R-beta, mTOR and CDC25A) and HCC related protein (SHP-2) were detected by qRT-PCR and Western blot in liver tissues. +other 31293968 hsa-mir-1260b Endometrial Neoplasms In the current study, we identified a microRNAs signature (miR-205, miR-146a, miR-1260b) able to discriminate between atypical and typical endometrial hyperplasia in two independent cohorts of patients. +other 31293968 hsa-mir-205 Endometrial Neoplasms In the current study, we identified a microRNAs signature (miR-205, miR-146a, miR-1260b) able to discriminate between atypical and typical endometrial hyperplasia in two independent cohorts of patients. +other 31293968 hsa-mir-146a Endometrial Neoplasms In the current study, we identified a microRNAs signature (miR-205, miR-146a, miR-1260b) able to discriminate between atypical and typical endometrial hyperplasia in two independent cohorts of patients. +circulation_biomarker_diagnosis_ns 31293746 hsa-mir-21 Breast Neoplasms Meanwhile, the effect of chemotherapy and radiotherapy on breast cancer is evaluated from the perspective of hsa-miR5p residue in serums. +other 31293662 hsa-mir-186 Carcinoma, Hepatocellular Taken together, SNHG16 promoted HCC cell proliferation, migration and invasion by functioning as a competitive endogenous RNA (ceRNA) to negatively regulate miR-186 expression. +transcription factor target 31293661 hsa-mir-506 Colorectal Neoplasms In conclusion, miR-506 acts as a tumor suppressor and inhibits proliferation, migration and invasion in colorectal cancer cells partly through decreasing NR4A1 expression. +genetics_overexpression_promote 31293642 hsa-mir-15b Carcinoma, Renal Cell Vector-mediated overexpression of miR-15b significantly induced resistance to sunitinib in ccRCC cells. +transcription factor target 31293639 hsa-mir-7 Carcinoma, Hepatocellular 5p, were reported to play pivotal roles in HCC progression by targeting multiple genes. +transcription factor target 31293639 hsa-mir-203a Carcinoma, Hepatocellular 5p, were reported to play pivotal roles in HCC progression by targeting multiple genes. +transcription factor target 31293639 hsa-mir-192 Carcinoma, Hepatocellular 5p, were reported to play pivotal roles in HCC progression by targeting multiple genes. +transcription factor target 31293639 hsa-mir-145 Carcinoma, Hepatocellular 5p, were reported to play pivotal roles in HCC progression by targeting multiple genes. +lncRNA target 31292722 hsa-mir-675 Carcinoma, Hepatocellular Moreover, Timp3 deletion in hepatocarcinogenesis during obesity is associated with a reduction in FoxM1 transcriptional activity through H19/miR-675/p53 pathway. +lncRNA target 31292722 hsa-mir-675 Obesity Moreover, Timp3 deletion in hepatocarcinogenesis during obesity is associated with a reduction in FoxM1 transcriptional activity through H19/miR-675/p53 pathway. +lncRNA target 31292246 hsa-mir-122 Hepatitis C The microRNA-122 antagonist miravirsen inhibited RHV-rn1 replication, demonstrating the importance of this HCV host factor for RHV. HCV antivirals targeting NS5A, NS5B, and microRNA-122 efficiently inhibited RHV replication. +lncRNA target 31292246 hsa-mir-122 Erythroblastosis, Fetal The microRNA-122 antagonist miravirsen inhibited RHV-rn1 replication, demonstrating the importance of this HCV host factor for RHV. HCV antivirals targeting NS5A, NS5B, and microRNA-122 efficiently inhibited RHV replication. +other 31292167 hsa-mir-144 Hyperglycemia Our previous study identified a down-regulated miRNA: miR3p in response to hyperglycemia. +transcription factor target 31292167 hsa-mir-144 Duane Retraction Syndrome 3p inhibited high glucose-induced cell proliferation through suppressing FGF16 and MAPK signaling pathway, suggesting a possible role of miR +lncRNA target 31291804 hsa-mir-146a Inflammation Silencing of MALAT1 suppressed LPS-induced NF-kappaB activation and TNF-alpha and IL-6 secretion, reducing the cell inflammatory injury, but these changes were reversed after combined treatment with miR-146a inhibitor. +lncRNA target 31291804 hsa-mir-146 Inflammation Silencing of MALAT1 suppressed LPS-induced NF-kappaB activation and TNF-alpha and IL-6 secretion, reducing the cell inflammatory injury, but these changes were reversed after combined treatment with miR-146a inhibitor. +other 31291448 hsa-mir-518b Early Embryonic Arrestdagger Our findings provide new insights into the role of miR-518b in EEA and implicate the potential application of miR-518b in the diagnosis and development of intervention for EEA. +genetics_knock down_suppress 31291201 hsa-mir-22 esophagus adenocarcinoma Loss of function approaches were used to investigate the biological role of MIR22HG in EAC cells. +other 31290727 hsa-mir-130a Stomach Neoplasms Aim: PD-L1 monoclonal antibody-conjugated miR-130a/oxaliplatin-loaded immunoliposomes were constructed for enhanced therapeutic efficacy against gastric cancer. +genetics_overexpression_promote 31289617 hsa-mir-873 Colorectal Neoplasms Overexpressing miR-873 suppressed proliferation and metastasis of CRC cells both in vitro and in vivo, while inhibiting miR-873 expression promoted the proliferation, migration and invasion in vitro. +genetics_knock down_suppress 31289611 hsa-mir-193a Mesothelioma, Malignant Our data suggest that in MPM, the downregulation of miR-15/16 is due to transcriptional repression by c-Myc, primarily via control of the miR-15b/16-2 locus, while miR-193a-3p loss is due to genomic deletion. +genetics_knock down_suppress 31289611 hsa-mir-15 Mesothelioma, Malignant MicroRNA downregulation is frequent in malignant pleural mesothelioma (MPM), but the mechanisms responsible for loss of miR-15/16 and miR-193a are yet to be elucidated and were investigated in this study. +lncRNA target 31289586 hsa-mir-92a Colorectal Neoplasms Furthermore, protein-protein interaction network was set up with miR-92a targets and screened for hub nodes and significant modules, which were confirmed strongly involved in the occurrence and development of CRC again. +genetics_overexpression_promote 31289572 hsa-mir-410 Rhabdomyosarcoma 3p overexpression suppressed invasion, migration and proliferation, downregulated the expression of EMT-associated molecules, and promoted apoptosis and the expression of apoptotic factors in RMS cells. +circulation_biomarker_diagnosis_ns 31289566 hsa-mir-125a Carcinoma, Hepatocellular Serum miR-125a-5p fluctuates depending on the presence of HCC, and may serve as a noninvasive biomarker to aid in diagnosing early carcinogenesis in HCV-associated chronic liver diseases. +circulation_biomarker_diagnosis_down 31289566 hsa-mir-648 Carcinoma, Hepatocellular The serum levels of miR-125a-5p in 40 individuals with HCV-associated chronic hepatitis (CH), liver cirrhosis (LC) or HCC were measured using reverse transcription-quantitative polymerase chain reaction, and 5 miRNAs, including miR-125a-5p, miR5p, miR-1247, miR-1304 and miR-3648, were identified to be downregulated following curative treatment in patients with HCC. +circulation_biomarker_diagnosis_down 31289566 hsa-mir-1304 Carcinoma, Hepatocellular The serum levels of miR-125a-5p in 40 individuals with HCV-associated chronic hepatitis (CH), liver cirrhosis (LC) or HCC were measured using reverse transcription-quantitative polymerase chain reaction, and 5 miRNAs, including miR-125a-5p, miR5p, miR-1247, miR-1304 and miR-3648, were identified to be downregulated following curative treatment in patients with HCC. +circulation_biomarker_diagnosis_down 31289566 hsa-mir-423 Carcinoma, Hepatocellular The serum levels of miR-125a-5p in 40 individuals with HCV-associated chronic hepatitis (CH), liver cirrhosis (LC) or HCC were measured using reverse transcription-quantitative polymerase chain reaction, and 5 miRNAs, including miR-125a-5p, miR5p, miR-1247, miR-1304 and miR-3648, were identified to be downregulated following curative treatment in patients with HCC. +lncRNA target 31289563 hsa-mir-124 Colorectal Neoplasms Hence, it was proposed that miR-124 dysregulation may negatively influence the expression of TRAF6 and therefore serve as a biomarker of epithelial-mesenchymal transition in CRC tissues. +circulation_biomarker_prognosis_ns 31289552 hsa-mir-145 Laryngeal Neoplasms The expression levels of miRNA-145 and miRNA-218 in serum of patients with laryngeal cancer decreased, the higher the expression levels of miRNA-145 and miRNA-218 in serum of patients with laryngeal cancer were, the better the prognosis was. +circulation_biomarker_prognosis_ns 31289552 hsa-mir-218 Laryngeal Neoplasms The expression levels of miRNA-145 and miRNA-218 in serum of patients with laryngeal cancer decreased, the higher the expression levels of miRNA-145 and miRNA-218 in serum of patients with laryngeal cancer were, the better the prognosis was. +circulation_biomarker_prognosis_ns 31289551 hsa-mir-155 Carcinoma, Non-Small-Cell Lung In conclusion, miR-155 and miR-21 were highly expressed in the serum of patients, however, the recurrence and metastasis of NSCLC were even higher. +circulation_biomarker_prognosis_ns 31289551 hsa-mir-21 Carcinoma, Non-Small-Cell Lung In conclusion, miR-155 and miR-21 were highly expressed in the serum of patients, however, the recurrence and metastasis of NSCLC were even higher. +genetics_overexpression_suppress 31289540 hsa-mir-27b Squamous Cell Carcinoma of Head and Neck The proliferation and migration ability of drug-resistant OSCC was significantly decreased after the addition of cisplatin in miR-27b overexpression (P<0.05). +genetics_overexpression_suppress 31289540 hsa-mir-27 Squamous Cell Carcinoma of Head and Neck The proliferation and migration ability of drug-resistant OSCC was significantly decreased after the addition of cisplatin in miR-27b overexpression (P<0.05). +genetics_overexpression_suppress 31289535 hsa-mir-141 Stomach Neoplasms Exogenous overexpression of miR-141 significantly inhibited the proliferative and migratory abilities of the gastric cancer cell line BGC-823. +lncRNA target 31289511 hsa-mir-148a Ovarian Neoplasms These results may provide theoretical basis for targeting miR-148a in the treatment of ovarian cancer. +other 31289507 hsa-mir-218 Glioblastoma The aim of the present study was to investigate the expression and function of survivin in glioblastoma, and to examine the association between survivin and miR-218. +genetics_overexpression_promote 31289502 hsa-mir-30 Liver Neoplasms 3p was overexpressed using mimic transfection. +circulation_biomarker_diagnosis_up 31289501 hsa-mir-338 Retinoblastoma 5p in the serum of patients with RB suggests that it may be involved in the formation of RB. +genetics_overexpression_promote 31289494 hsa-mir-505 Breast Neoplasms The results of cell experiments revealed that an overexpression of miR-505 could significantly inhibit BCa cell proliferation, migration and invasion, whereas a downregulation of miR-505 significantly enhanced BCa cell proliferation, migration and invasion (P<0.05). +genetics_knock down_suppress 31289483 hsa-mir-200c Stomach Neoplasms In conclusion, overexpression of miR-200c-3p may reverse drug resistance in the SGC7901/DDP GC cell line via downregulation of ERCC3 and ERCC4, which suggested this may be part of a mechanism involving the NER pathway. +genetics_overexpression_promote 31289482 hsa-mir-20b Carcinoma, Non-Small-Cell Lung miR-20b-5p overexpression was revealed to promote NSCLC cell proliferation and migration. +lncRNA target 31289477 hsa-mir-155 Leukemia, Lymphocytic, Chronic, B-Cell The results of the present study suggested that treatment with IL-4 enhanced the expression of miR-155, which regulated CLL cell survival via the enhanced phosphorylation of STAT6. +transcription factor target 31289476 hsa-mir-20a Osteosarcoma By implementing a series of experimental techniques in molecular biology, including reverse transcription-quantitative polymerase chain reaction and a double fluorescence reporter assay, it was demonstrated that the expression of miR-20a was high and inhibited the expression of QKI2 in OS. In conclusion, it was revealed that aberrantly upregulated miR-20a inhibited the expression of QKI2 in OS by targeting QKI2 mRNA, subsequently promoting the proliferation, migration and invasion of OS cells. +lncRNA target 31289363 hsa-mir-204 Ovarian Neoplasms In this study, miRNA profiling of patient data sets, along with in vitro and in vivo experiments, revealed that miR5p could promote angiogenesis in ovarian tumors through THBS1. +lncRNA target 31289307 hsa-mir-410 Hypertension, Pulmonary Our results highlight the role of miR410 in the regulation of NAMPT expression in hPAECs and show that miR410 plays a potential role in PAH pathobiology by targeting a modulator of pulmonary vascular remodeling. +transcription factor target 31289307 hsa-mir-410 Vascular Remodeling Our results highlight the role of miR410 in the regulation of NAMPT expression in hPAECs and show that miR410 plays a potential role in PAH pathobiology by targeting a modulator of pulmonary vascular remodeling. +epigenetics 31289088 hsa-mir-124-2 Cervical Intraepithelial Neoplasia At baseline and during follow-up, self-sampled cervicovaginal brushes and cervical scrapes will be collected for high-risk human papillomavirus (HPV) testing and FAM19A4/miR124-2 methylation analysis. +genetics_overexpression_promote 31288899 hsa-mir-1225 Thyroid Neoplasms 5p overexpression alone on the malignant phenotypes of thyroid cancer cells. +other 31288577 hsa-mir-200c Encephalocele The pDNA encoding miR-200c also significantly enhanced bone formation and regeneration in calvarial defects of rat models. +genetics_knock down_suppress 31288529 hsa-mir-140 Carcinoma, Non-Small-Cell Lung The results suggested that SNHG1 knockdown ameliorated DDP-resistance of NSCLC by regulating miR +circulation_biomarker_diagnosis_ns 31287847 hsa-mir-451a Edema Since excessive pro-inflammatory cytokine production is a cause of the local adverse reactions to vaccination, we investigated whether miR-451a levels in serum EVs correlate with local symptoms at the vaccination site, such as pain, itching, swelling, and redness. +circulation_biomarker_diagnosis_ns 31287847 hsa-mir-451a Influenza, Human Previous studies have shown that circulating EV miR-451a regulates innate immune responses, and miR-451a levels in serum EVs are negatively correlated with the pro-inflammatory cytokine expression levels in response to the influenza vaccine. +circulation_biomarker_diagnosis_ns 31287847 hsa-mir-451a Pruritus Since excessive pro-inflammatory cytokine production is a cause of the local adverse reactions to vaccination, we investigated whether miR-451a levels in serum EVs correlate with local symptoms at the vaccination site, such as pain, itching, swelling, and redness. +circulation_biomarker_diagnosis_ns 31287847 hsa-mir-451a Relative Energy Deficiency in Sport Since excessive pro-inflammatory cytokine production is a cause of the local adverse reactions to vaccination, we investigated whether miR-451a levels in serum EVs correlate with local symptoms at the vaccination site, such as pain, itching, swelling, and redness. +genetics_overexpression_promote 31287793 hsa-mir-99b Stomach Neoplasms Further study indicates that miR-99b-3p inhibits cell viability and induces cell arrest in the S-phase in GC cells, the direct target gene of miR-99b-3p is verified to be HoxD3, which is also overexpressed in GC cell lines. +genetics_overexpression_promote 31287414 hsa-mir-451 ankylosing spondylitis 1 CONCLUSIONS: The MIF level was elevated in AS patients with greater radiographic damage and overexpression of miR-451 suppressed the MIF and inflammatory cytokine levels. +lncRNA target 31287095 hsa-mir-204 Lung Neoplasms CONCLUSIONS LINC00922 was upregulated in lung cancer, and accelerated lung cancer cells to proliferate, migrate, and invade via targeting the miRNA-204/CXCR4 axis. +lncRNA target 31287025 hsa-mir-365 Osteoarthritis Transfection of miR-365 in OA-MSC induced chondrogenic, hypertrophic, and osteogenic genes expression while miR-365 inhibition suppressed the expression of these genes. +epigenetics 31287003 hsa-mir-888 Urinary Bladder Neoplasms Upon hypomethylation in invasive BC cells, MIR888 is transactivated by E2F1 and represses APLF. Depletion of miR-888 can establish a 'high E2F1/APLF/DCLRE1C' signature, which was found to be particularly favorable for BC patient survival. +other 31287002 hsa-mir-361 Endometrial Neoplasms CONCLUSIONS NEAT1 initiates a miRmediated network to drive aggressive EC progression. +genetics_overexpression_promote 31286834 hsa-mir-124 Breast Neoplasms To further understand the inner mechanism of drug resistance in breast cancer and look for remedy methods, we referred to bioinformatic analysis and predicted that signal transducer and activator of transcription 3 (STAT3) and miR-124 was overexpressed in MCF7-R cells (MCF7 cells resistant to DOX) compared with MCF cells. +other 31286390 hsa-mir-21 Diabetes Mellitus We also showed that the expression of miR-21 in people with type 2 diabetes increased compared to healthy people. +other 31286390 hsa-mir-21 Diabetes Mellitus, Type 2 In addition to semi-quantitative method, the miR-21 quantity was determined by quantitative method in several patients with type 2 diabetes and healthy people. We also showed that the expression of miR-21 in people with type 2 diabetes increased compared to healthy people. +circulation_biomarker_diagnosis_up 31285872 hsa-mir-5187 Coronary Occlusion CONCLUSIONS: These results suggested that circulating miR +other 31285779 hsa-mir-551b Diabetic Cardiomyopathies Conclusion: Our study suggests that DCRF can act as a competing endogenous RNA to increase PCDH17 expression by sponging miR-551b-5p, thus contributing to increased cardiomyocyte autophagy in DCM. +other 31285693 hsa-mir-146a Digestive System Neoplasms In a pooled analysis, the high miR-146a-5p expression group showed a better overall survival in solid cancers, particularly in reproductive system cancers and digestive system cancers. CONCLUSION: There is a close link between high miR-146a-5p expression and better overall survival in 21 types of solid cancer, especially in reproductive system and digestive system cancers. +other 31285693 hsa-mir-146a Digestive System Diseases In a pooled analysis, the high miR-146a-5p expression group showed a better overall survival in solid cancers, particularly in reproductive system cancers and digestive system cancers. CONCLUSION: There is a close link between high miR-146a-5p expression and better overall survival in 21 types of solid cancer, especially in reproductive system and digestive system cancers. +other 31285693 hsa-mir-146a Nervous System Neoplasms In a pooled analysis, the high miR-146a-5p expression group showed a better overall survival in solid cancers, particularly in reproductive system cancers and digestive system cancers. CONCLUSION: There is a close link between high miR-146a-5p expression and better overall survival in 21 types of solid cancer, especially in reproductive system and digestive system cancers. +lncRNA target 31285693 hsa-mir-146a Lung Neoplasms Potential target genes of miR-146a-5p in lung cancer were validated by RT-qPCR. AQP1 and FYN were validated by RT-qPCR to be potential targets of miR-146a-5p in lung cancer. +other 31285693 hsa-mir-146a Genital Neoplasms, Female In a pooled analysis, the high miR-146a-5p expression group showed a better overall survival in solid cancers, particularly in reproductive system cancers and digestive system cancers. +lncRNA target 31285444 hsa-mir-212 Carcinoma, Hepatocellular 3p through its ability to suppress CTGF and subsequent EMT. +transcription factor target 31284955 hsa-mir-7218 Obesity 5p was verified to affect MIN6 cell proliferation through targeting CD74 gene. +other 31284864 hsa-mir-223 Instent Restenosis In this study, our aim was to assess the impact of miR-223 modulation on restenosis in a rat model of carotid artery after balloon injury. CONCLUSION: Down-regulating miR-223 could be a potential therapeutic approach to prevent restenosis after angioplasty. +circulation_biomarker_diagnosis_ns 31284700 hsa-mir-30 Metabolic Diseases In the present study, we evaluated the serum levels of miRNAs associated with GDM (miR +circulation_biomarker_diagnosis_ns 31284700 hsa-mir-29a Diabetes, Gestational In the present study, we evaluated the serum levels of miRNAs associated with GDM (miR +circulation_biomarker_diagnosis_ns 31284700 hsa-mir-29a Metabolic Diseases In the present study, we evaluated the serum levels of miRNAs associated with GDM (miR +circulation_biomarker_diagnosis_ns 31284700 hsa-mir-30 Diabetes, Gestational In the present study, we evaluated the serum levels of miRNAs associated with GDM (miR +circulation_biomarker_diagnosis_ns 31284700 hsa-mir-9 Diabetes, Gestational In the present study, we evaluated the serum levels of miRNAs associated with GDM (miR +circulation_biomarker_diagnosis_ns 31284700 hsa-mir-9 Metabolic Diseases In the present study, we evaluated the serum levels of miRNAs associated with GDM (miR +transcription factor target 31284665 hsa-mir-21 Glioblastoma Our results demonstrated that RNV541, a potential arm-loop-arm type antimiRzyme, was very efficient (90%) to suppress miR-21 expression in U87MG malignant glioblastoma cell line at 200 nM concentration. TfR aptamer-RNV541 chimeric construct showed 52% inhibition of miR-21 expression in U87MG glioblastoma cells at 2000 nM concentration, without using any transfection reagents, making it a highly desirable strategy to tackle miR-21 over-expressed malignant cancers. +target gene 31284665 hsa-mir-21 Breast Neoplasms In addition, RNV541 also inhibited miR-21 expression (50%) in MDA-MB-231 breast cancer cell line. +circulation_biomarker_diagnosis_ns 31284309 hsa-mir-210 Glaucoma, Open-Angle Conclusions Circulating hsa-miR +other 31284290 hsa-mir-142 Neurotic Disorders Among the 121 miRNAs 22 were nominally significantly associated with CT and four of them (let-7g-5p, miR-103a-3p, miR-107, and miR3p) also after correction for multiple testing; most of them were previously associated with Alzheimer's disease (AD) or depression. +other 31284290 hsa-let-7g Neurotic Disorders Among the 121 miRNAs 22 were nominally significantly associated with CT and four of them (let-7g-5p, miR-103a-3p, miR-107, and miR3p) also after correction for multiple testing; most of them were previously associated with Alzheimer's disease (AD) or depression. +other 31284290 hsa-mir-142 Alzheimer Disease Among the 121 miRNAs 22 were nominally significantly associated with CT and four of them (let-7g-5p, miR-103a-3p, miR-107, and miR3p) also after correction for multiple testing; most of them were previously associated with Alzheimer's disease (AD) or depression. +other 31284290 hsa-let-7g Alzheimer Disease Among the 121 miRNAs 22 were nominally significantly associated with CT and four of them (let-7g-5p, miR-103a-3p, miR-107, and miR3p) also after correction for multiple testing; most of them were previously associated with Alzheimer's disease (AD) or depression. +other 31284290 hsa-mir-103a Celiac Disease Among the 121 miRNAs 22 were nominally significantly associated with CT and four of them (let-7g-5p, miR-103a-3p, miR-107, and miR3p) also after correction for multiple testing; most of them were previously associated with Alzheimer's disease (AD) or depression. +other 31284290 hsa-mir-103a Neurotic Disorders Among the 121 miRNAs 22 were nominally significantly associated with CT and four of them (let-7g-5p, miR-103a-3p, miR-107, and miR3p) also after correction for multiple testing; most of them were previously associated with Alzheimer's disease (AD) or depression. +other 31284290 hsa-mir-142 Celiac Disease Among the 121 miRNAs 22 were nominally significantly associated with CT and four of them (let-7g-5p, miR-103a-3p, miR-107, and miR3p) also after correction for multiple testing; most of them were previously associated with Alzheimer's disease (AD) or depression. +other 31284290 hsa-mir-103a Alzheimer Disease Among the 121 miRNAs 22 were nominally significantly associated with CT and four of them (let-7g-5p, miR-103a-3p, miR-107, and miR3p) also after correction for multiple testing; most of them were previously associated with Alzheimer's disease (AD) or depression. +other 31284290 hsa-let-7g Celiac Disease Among the 121 miRNAs 22 were nominally significantly associated with CT and four of them (let-7g-5p, miR-103a-3p, miR-107, and miR3p) also after correction for multiple testing; most of them were previously associated with Alzheimer's disease (AD) or depression. +lncRNA target 31284128 hsa-mir-892b Hypertrophy miR-892b enhanced chondrogenic makers and suppressed hypertrophy in hMSC chondrogenesis, mimicking parathyroid hormone-related peptide (PTHrP). +other 31284127 hsa-mir-877 Iris Diseases 3p/Bcl-2 pathway is involved in regulation of mitochondrial apoptosis during myocardial I/RI, which provided new insight into molecular mechanisms underlying regulation of myocardial I/RI. +other 31284127 hsa-mir-877 Cardiomyopathies 3p/Bcl-2 pathway is involved in regulation of mitochondrial apoptosis during myocardial I/RI, which provided new insight into molecular mechanisms underlying regulation of myocardial I/RI. +genetics_knock down_promote 31283928 hsa-mir-375 Carcinoma, Merkel Cell Luciferase assays revealed binding of ATOH1 and subsequent activation to the promoter of miR-375, which is one of the most abundant microRNAs in MCCs. Overexpression of ATOH1 in variant MCC cell lines and fibroblasts induced miR-375 expression, whereas ATOH1 knockdown in classical MCC cell lines reduced miR-375 expression. +genetics_overexpression_suppress 31283925 hsa-mir-92b Cardiomegaly Overexpression of miR-92b-3p can ameliorate Ang-II-induced cardiomyocyte hypertrophy. +genetics_overexpression_promote 31283714 hsa-mir-622 Glioblastoma Therefore, plasma SAMMSON has diagnostic value for glioblastoma and SAMMSON overexpression may promote glioblastoma cell proliferation by downregulating miR-622. +genetics_overexpression_promote 31283714 hsa-mir-622 Neurosarcoidosis Therefore, plasma SAMMSON has diagnostic value for glioblastoma and SAMMSON overexpression may promote glioblastoma cell proliferation by downregulating miR-622. +circulation_biomarker_diagnosis_ns 31283712 hsa-mir-205 Intracranial Aneurysm High blood levels of microRNA-205 showed diagnostic values for intracranial aneurysms. +other 31283072 hsa-mir-744 Cleft Palate, Non-Syndromic Taken together, these findings suggest that rs2262251 is associated with the risk of NSCL/P and participates in a lncRNA-miRNA-mRNA regulatory axis in which miR5p and IQSEC2 combine to control NSCL/P development. +other 31283072 hsa-mir-744 Cleft Palate Taken together, these findings suggest that rs2262251 is associated with the risk of NSCL/P and participates in a lncRNA-miRNA-mRNA regulatory axis in which miR5p and IQSEC2 combine to control NSCL/P development. +other 31283068 hsa-mir-199a Triple Negative Breast Neoplasms We establish that LINC01133 is sufficient, on its own, in promoting phenotypic and growth characteristics of cancer stem cell-like cells, and that it is a direct mediator of the MSC-triggered miR-199a-FOXP2 pathway in TNBC models. +other 31282806 hsa-mir-200a Hyperglycemia Some of the identified miRNAs, such as miRNA-27b-3p and miRNA-200a-3p, are known to be responsive to hyperglycemia in the liver of hyperglycemic glucose-tolerant fish and mammals, suggesting an evolutionary conserved regulation. +other 31282806 hsa-mir-27b Hyperglycemia Some of the identified miRNAs, such as miRNA-27b-3p and miRNA-200a-3p, are known to be responsive to hyperglycemia in the liver of hyperglycemic glucose-tolerant fish and mammals, suggesting an evolutionary conserved regulation. +other 31282597 hsa-mir-124 Fatigue Syndrome, Chronic Differential expression of miR-558, miR-146a, miR-150, miR-124, and miR-143 was significantly downregulated and notably interfered with pain intensity and frequency in patients with CFS. CONCLUSIONS: The intensity and consequences of pain were influenced by differential expression of miR-558, miR-146a, miR-150, miR-124, and miR-143, which was directly associated with higher expression of the immune inflammatory-related genes TNFalpha, IL-6, and COX-2 in adolescents with CFS. +other 31282597 hsa-mir-143 Fatigue Syndrome, Chronic Differential expression of miR-558, miR-146a, miR-150, miR-124, and miR-143 was significantly downregulated and notably interfered with pain intensity and frequency in patients with CFS. CONCLUSIONS: The intensity and consequences of pain were influenced by differential expression of miR-558, miR-146a, miR-150, miR-124, and miR-143, which was directly associated with higher expression of the immune inflammatory-related genes TNFalpha, IL-6, and COX-2 in adolescents with CFS. +other 31282597 hsa-mir-150 Fatigue Syndrome, Chronic Differential expression of miR-558, miR-146a, miR-150, miR-124, and miR-143 was significantly downregulated and notably interfered with pain intensity and frequency in patients with CFS. CONCLUSIONS: The intensity and consequences of pain were influenced by differential expression of miR-558, miR-146a, miR-150, miR-124, and miR-143, which was directly associated with higher expression of the immune inflammatory-related genes TNFalpha, IL-6, and COX-2 in adolescents with CFS. +other 31282597 hsa-mir-146a Fatigue Syndrome, Chronic Differential expression of miR-558, miR-146a, miR-150, miR-124, and miR-143 was significantly downregulated and notably interfered with pain intensity and frequency in patients with CFS. CONCLUSIONS: The intensity and consequences of pain were influenced by differential expression of miR-558, miR-146a, miR-150, miR-124, and miR-143, which was directly associated with higher expression of the immune inflammatory-related genes TNFalpha, IL-6, and COX-2 in adolescents with CFS. +other 31282597 hsa-mir-558 Fatigue Syndrome, Chronic Differential expression of miR-558, miR-146a, miR-150, miR-124, and miR-143 was significantly downregulated and notably interfered with pain intensity and frequency in patients with CFS. CONCLUSIONS: The intensity and consequences of pain were influenced by differential expression of miR-558, miR-146a, miR-150, miR-124, and miR-143, which was directly associated with higher expression of the immune inflammatory-related genes TNFalpha, IL-6, and COX-2 in adolescents with CFS. +circRNA target 31282213 hsa-mir-214 Hypoxia deficient NSCs showed the reduction in cell viability and the facilitation in apoptosis progress after pre-treatment with puerarin and stimulation in a hypoxia circumstance. +lncRNA target 31282110 hsa-mir-29a Cataract, Age-Related lncRNA H19 could be a useful marker of early ARC and oxidative damage repair pathway of lncRNA H19/miR-29a/TDG may be a promising target for the treatment of ARC. +lncRNA target 31281935 hsa-mir-23a Colorectal Neoplasms MiR-23a may be a potential therapeutic target for colorectal cancer treatment. +other 31281725 hsa-mir-429 Breast Neoplasms CONCLUSION: The miR-148b-3p, miR-190b, and miR-429 may serve as potential diagnostic and prognostic markers for breast cancer. +other 31281725 hsa-mir-148b Breast Neoplasms CONCLUSION: The miR-148b-3p, miR-190b, and miR-429 may serve as potential diagnostic and prognostic markers for breast cancer. +other 31281725 hsa-mir-190b Breast Neoplasms CONCLUSION: The miR-148b-3p, miR-190b, and miR-429 may serve as potential diagnostic and prognostic markers for breast cancer. +circulation_biomarker_diagnosis_ns 31281513 hsa-mir-338 Osteoporosis, Postmenopausal Conclusion: Circulating miR-338 cluster in the serum could serve as a promising diagnostic and therapeutic target for postmenopausal osteoporosis patients. +lncRNA target 31281461 hsa-mir-432 Adenocarcinoma of Lung Ophiopogonin-B Suppresses Epithelial-mesenchymal Transition in Human Lung Adenocarcinoma Cells via the Linc00668/miR5p/EMT Axis. +circulation_biomarker_diagnosis_up 31281456 hsa-mir-4432 Pre-Eclampsia 5p, hiv1-miR-TAR-3p, hsa-miR-4432 and hsa-miR-4498 that were significantly downregulated in the plasma of preeclampsia patients. +circulation_biomarker_diagnosis_up 31281456 hsa-mir-4498 Pre-Eclampsia 5p, hiv1-miR-TAR-3p, hsa-miR-4432 and hsa-miR-4498 that were significantly downregulated in the plasma of preeclampsia patients. +circulation_biomarker_diagnosis_up 31281456 hsa-mir-188 Pre-Eclampsia 5p, hiv1-miR-TAR-3p, hsa-miR-4432 and hsa-miR-4498 that were significantly downregulated in the plasma of preeclampsia patients. +circulation_biomarker_diagnosis_up 31281456 hsa-mir-211 Pre-Eclampsia 5p, hiv1-miR-TAR-3p, hsa-miR-4432 and hsa-miR-4498 that were significantly downregulated in the plasma of preeclampsia patients. +lncRNA target 31281454 hsa-mir-146a Sepsis In the miR-146a agonist group, levels of myocardial injury markers were lower than those in the sepsis model group, but were higher in the miR-146a inhibition group. +lncRNA target 31281454 hsa-mir-146a Cardiomyopathies In the miR-146a agonist group, levels of myocardial injury markers were lower than those in the sepsis model group, but were higher in the miR-146a inhibition group. +circulation_biomarker_diagnosis_up 31281441 hsa-mir-184 Burns The reverse transcription-quantitative polymerase chain reaction (RT-q.PCR) was used to detect the expression of miR-184 and miR-126 in the serum of three groups of burned rats, and ELISA was employed to detect the expression levels in peripheral blood and the correlation. +circulation_biomarker_diagnosis_up 31281441 hsa-mir-126 Burns The reverse transcription-quantitative polymerase chain reaction (RT-q.PCR) was used to detect the expression of miR-184 and miR-126 in the serum of three groups of burned rats, and ELISA was employed to detect the expression levels in peripheral blood and the correlation. +transcription factor target 31281310 hsa-mir-130a Sjogren's Syndrome miR-130a targets MSK1, which regulates pro-inflammatory cytokine production, and we provide proof-of-concept for MSK1-inhibition as a therapeutic avenue to impede cDC2 activity in pSS. +circulation_biomarker_diagnosis_up 31281212 hsa-mir-146a Renal Insufficiency CONCLUSIONS: The expression levels of serum miR-30d-5p, miR-23a-3p, miR5p did not significantly differ between three groups of patients who developed ARF, had CRF, or retained NRF. +circulation_biomarker_diagnosis_up 31281212 hsa-mir-23a Renal Insufficiency CONCLUSIONS: The expression levels of serum miR-30d-5p, miR-23a-3p, miR5p did not significantly differ between three groups of patients who developed ARF, had CRF, or retained NRF. +circulation_biomarker_diagnosis_up 31281212 hsa-mir-146 Renal Insufficiency CONCLUSIONS: The expression levels of serum miR-30d-5p, miR-23a-3p, miR5p did not significantly differ between three groups of patients who developed ARF, had CRF, or retained NRF. +lncRNA target 31280269 hsa-mir-591 Carcinoma, Hepatocellular Above results highlighted an inhibitory effect of miR-591 on the development of HCC by reducing the drug resistance of HCC stem cells. +genetics_overexpression_promote 31280017 hsa-mir-1 Ossification of Posterior Longitudinal Ligament Likewise, induced OPLL caused by overexpression of MALAT1 can be ameliorated by enhanced miR-1 function, knock-down of Cx43 or inhibition of inflammation. +transcription factor target 31279826 hsa-mir-191a Sleep Deprivation Hippocampal BDNF is probably one of the targets of miR-191a in sleep-deprived OVX rats. Our results suggest that miR-191a may be increased in the sleep-deprived OVX rats to regulate BDNF levels. +other 31279225 hsa-mir-206 Bronchial Diseases However, the involvement of miR-206 in airway inflammatory diseases is still uninvestigated. +genetics_overexpression_promote 31279225 hsa-mir-206 Inflammation MiR-206 overexpression aggravated LPS-induced inflammation injury in MRC-5 cells. +other 31279225 hsa-mir-206 Pulmonary Disease, Chronic Obstructive The study aimed to explore the effect of miR-206 on lipopolysaccharide (LPS)-induced inflammation injury in MRC-5 cells, and point out a potential relevance for chronic obstructive pulmonary disease (COPD). +lncRNA target 31278963 hsa-mir-942 Colorectal Neoplasms Taken together, our findings established an oncogenic role for miR-942 in CRC and indicated that this miRNA might be a crucial target for CRC therapy. +other 31278961 hsa-mir-34a Peripheral Nervous System Diseases The present study underlines that the induction and maintenance of neuropathic pain is accompanied by expression changes of miRNAs in the peripheral nervous system, adding several previously unreported miRNAs, including miR-34a. +other 31278779 hsa-mir-1 psoriasis 1 These findings confirm the important role of miR-31 in psoriasis onset and provide a basis for further investigations in miRNAs field in context of skin diseases. +transcription factor target 31278688 hsa-mir-423 Fibrosis 5p may be useful as a therapeutic target for treating hepatic fibrosis. +lncRNA target 31278653 hsa-mir-21 Esophageal Squamous Cell Carcinoma Association between miR-21 and Th subsets could be correlated with the impairment of anti-tumor immunity and ESCC pathogenesis, which could be potentially used as an important target for immunotherapeutic approaches. +lncRNA target 31278653 hsa-mir-21 Esophageal Neoplasms Association between miR-21 and Th subsets could be correlated with the impairment of anti-tumor immunity and ESCC pathogenesis, which could be potentially used as an important target for immunotherapeutic approaches. +lncRNA target 31278368 hsa-mir-654 Ovarian Neoplasms 5p levels reduced tumor cell viability in vitro and in vivo and impaired sphere formation capacity and viability of ovarian cancer patient-derived ascitic cells ex vivo. +genetics_overexpression_promote 31278310 hsa-mir-214 Prostatic Neoplasms Importantly, miR-214 overexpression in prostate cancer cells induced apoptosis, inhibiting cell proliferation and colony forming ability. +lncRNA target 31278132 hsa-mir-218 Carcinoma, Hepatocellular In summary, our results indicate that circRNA-104718 acts as a ceRNA and promotes HCC progression through the targeting of miR +other 31278071 hsa-let-7g Carcinoma, Hepatocellular The TCGA database was used to evaluate the correlation among P4HA2, let-7g, LMCD1-AS1 and overall survival of HCC patients. +lncRNA target 31278033 hsa-mir-1251 Ovarian Neoplasms 5p/TBCC/alpha/beta-tubulin axis may be targeted for ovarian cancer treatment. +genetics_knock down_promote 31277702 hsa-mir-203a Ovarian Neoplasms Human ovarian cancer cell lines (A2780 and SKOV3) were used to generate the Blank, miR-NC, miR-203a-3p mimic, Control siRNA, ATM siRNA, and miR-203a-3p inhibitor ATM siRNA groups. +other 31277558 hsa-mir-626 Macular Degeneration 5p showed significantly lower expression. +other 31277558 hsa-mir-885 Macular Degeneration 5p showed significantly lower expression. +genetics_overexpression_promote 31277414 hsa-mir-526b Breast Neoplasms Ectopic overexpression of miR526b and miR655 in poorly metastatic estrogen receptor (ER) positive MCF7 breast cancer cells resulted in upregulation of angiogenesis and lymphangiogenesis markers vascular endothelial growth factor A (VEGFA); VEGFC; VEGFD; COX-2; lymphatic vessel endothelial hyaluronan receptor-1 (LYVE1); and receptors VEGFR1, VEGFR2, and EP4. Moreover, in breast tumors, angiogenesis marker VEGFA and lymphangiogenesis marker VEGFD expression was found to be significantly higher compared with non-adjacent control, and expression of miR526b and miR655 was positively correlated with VEGFA, VEGFC, VEGFD, CD31, and LYVE1 expression in breast tumour samples. +genetics_overexpression_promote 31277414 hsa-mir-655 Breast Neoplasms Ectopic overexpression of miR526b and miR655 in poorly metastatic estrogen receptor (ER) positive MCF7 breast cancer cells resulted in upregulation of angiogenesis and lymphangiogenesis markers vascular endothelial growth factor A (VEGFA); VEGFC; VEGFD; COX-2; lymphatic vessel endothelial hyaluronan receptor-1 (LYVE1); and receptors VEGFR1, VEGFR2, and EP4. Moreover, in breast tumors, angiogenesis marker VEGFA and lymphangiogenesis marker VEGFD expression was found to be significantly higher compared with non-adjacent control, and expression of miR526b and miR655 was positively correlated with VEGFA, VEGFC, VEGFD, CD31, and LYVE1 expression in breast tumour samples. +other 31277223 hsa-mir-203a Stress Disorders, Post-Traumatic The concentration changes of miR-203a-3p in EV and miR5p in EVD were confirmed in an independent validation cohort that consisted of 20 veterans (10 with and 10 without PTSD) using qPCR. +other 31277223 hsa-mir-339 Stress Disorders, Post-Traumatic The concentration changes of miR-203a-3p in EV and miR5p in EVD were confirmed in an independent validation cohort that consisted of 20 veterans (10 with and 10 without PTSD) using qPCR. +other 31277149 hsa-mir-9 Esophageal Squamous Cell Carcinoma Hsa-miR3p, hsa-miR-34c-3p and FOS were related to patient prognosis and higher expression of the transcripts were associated with a poor OS in patients with ESCC.Our study revealed the miRNA-mediated hub genes regulatory network as a model for predicting the molecular mechanism of ESCC. +other 31277149 hsa-mir-34c Esophageal Squamous Cell Carcinoma Hsa-miR3p, hsa-miR-34c-3p and FOS were related to patient prognosis and higher expression of the transcripts were associated with a poor OS in patients with ESCC.Our study revealed the miRNA-mediated hub genes regulatory network as a model for predicting the molecular mechanism of ESCC. +transcription factor target 31277135 hsa-mir-29 Diabetic Nephropathies The relationships between miRNAs and target genes were constructed, showing that miR-29 targeted COL4A and VEGFA, miR-200 targeted VEGFA, miR-25 targeted ITGAV, and miR-27 targeted EGFR.MiR-29 and miR-200 may play important roles in DN. VEGFA and COL4A5 were targeted by miR-29 and VEGFA by miR-200, which may mediate multiple signaling pathways leading to the pathogenesis and development of DN. +transcription factor target 31277135 hsa-mir-200 Diabetic Nephropathies The relationships between miRNAs and target genes were constructed, showing that miR-29 targeted COL4A and VEGFA, miR-200 targeted VEGFA, miR-25 targeted ITGAV, and miR-27 targeted EGFR.MiR-29 and miR-200 may play important roles in DN. VEGFA and COL4A5 were targeted by miR-29 and VEGFA by miR-200, which may mediate multiple signaling pathways leading to the pathogenesis and development of DN. +transcription factor target 31276956 hsa-mir-137 Carcinoma, Non-Small-Cell Lung Most importantly, the complex combines the inhibitory function of the GL21.T aptamer and miR-137, leading to a negative impact on NSCLC migration and growth. +other 31276668 hsa-mir-206 Breast Neoplasms BACKGROUND: Although the function of microRNA-21 and microRNA-206 in breast cancer cells have been investigated in vitro, their association with estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) are not reported. RESULTS: microRNA-21 was up-regulated in HER2 positive and Basal-like breast cancer types, while microRNA-206 was up-regulated in Luminal A and B types of breast cancer. +other 31276668 hsa-mir-21 Breast Neoplasms BACKGROUND: Although the function of microRNA-21 and microRNA-206 in breast cancer cells have been investigated in vitro, their association with estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) are not reported. RESULTS: microRNA-21 was up-regulated in HER2 positive and Basal-like breast cancer types, while microRNA-206 was up-regulated in Luminal A and B types of breast cancer. +circRNA target 31276627 hsa-mir-637 Stomach Neoplasms Therefore, in GC cells, circ-NOTCH1 inhibits the transcriptional activity of miR-637, thereby upregulating the expression of its target gene Apelin and regulating cell proliferation, apoptosis, and invasiveness. +transcription factor target 31276526 hsa-mir-164 Dehydration Expression analysis of these drought-responsive miRNA-mRNA modules revealed miR164-MYB, miR164-NAC, miR159-MYB, miR156-SPL and miR160-ARF showed a negative regulatory relationship. Further analysis showed that the miR164-MYB and miR164-NAC modules in the tolerant line modulated the stress response in an ABA (abscisic acid)-dependent manner, while the miR156-SPL and miR160-ARF modules in the sensitive line participated in the inhibition of metabolism in drought-exposed leaves. +other 31276526 hsa-mir-159 Dehydration Expression analysis of these drought-responsive miRNA-mRNA modules revealed miR164-MYB, miR164-NAC, miR159-MYB, miR156-SPL and miR160-ARF showed a negative regulatory relationship. +transcription factor target 31276526 hsa-mir-156 Dehydration Expression analysis of these drought-responsive miRNA-mRNA modules revealed miR164-MYB, miR164-NAC, miR159-MYB, miR156-SPL and miR160-ARF showed a negative regulatory relationship. Further analysis showed that the miR164-MYB and miR164-NAC modules in the tolerant line modulated the stress response in an ABA (abscisic acid)-dependent manner, while the miR156-SPL and miR160-ARF modules in the sensitive line participated in the inhibition of metabolism in drought-exposed leaves. +transcription factor target 31276526 hsa-mir-160 Dehydration Expression analysis of these drought-responsive miRNA-mRNA modules revealed miR164-MYB, miR164-NAC, miR159-MYB, miR156-SPL and miR160-ARF showed a negative regulatory relationship. Further analysis showed that the miR164-MYB and miR164-NAC modules in the tolerant line modulated the stress response in an ABA (abscisic acid)-dependent manner, while the miR156-SPL and miR160-ARF modules in the sensitive line participated in the inhibition of metabolism in drought-exposed leaves. +genetics_overexpression_promote 31276465 hsa-mir-214 Osteosarcoma In contrast, overexpression of miR +transcription factor target 31276277 hsa-mir-26b Carcinoma, Hepatocellular Thus, miR-26b-5p and HSPA8 could serve as molecular targets for selectively eliminating the Ep(+) CSC population in human HCCs. +genetics_overexpression_suppress 31276207 hsa-mir-195 Colorectal Neoplasms In addition, the EMT process of CRC cells was facilitated markedly against the contexts of overexpressed SNHG1 and underexpressed miR +genetics_overexpression_suppress 31276207 hsa-mir-497 Colorectal Neoplasms In addition, the EMT process of CRC cells was facilitated markedly against the contexts of overexpressed SNHG1 and underexpressed miR +lncRNA target 31275988 hsa-mir-214 Squamous Cell Carcinoma of Head and Neck 3p/PIM1 axis in the drug resistance of OSCC and provide potential targets for improving chemotherapy of OSCC. +circulation_biomarker_diagnosis_ns 31275888 hsa-mir-17 Obesity CONCLUSIONS: The results suggest that serum miR-17 is involved in the regulation of glucose and calcium homeostasis, which may contribute to the development of type 2 diabetes. +genetics_knock down_promote 31275638 hsa-mir-24-1 ST Elevation Myocardial Infarction This study aims to evaluate (1) serum concentration of osteogenesis/osteolysis factors panel (Dickkopf-related protein 1 (DKK-1), TNF-alpha, N-terminal atrial natriuretic peptide (NT-proANP), thrombospondin-2 (TSP-2), osteoprotegerin (OPG), osteocalcin (OCN), osteopontin (OPN), fibroblast growth factor 23 (FGF-23), soluble receptor activator of nuclear factor-kappaB ligand (sRANKL), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), proprotein convertase subtilisin/kexin type 9 (PCSK9)), (2) serum expression levels of micro-RNA- (miR-) 24-1 and miR-6802, and (3) assess their correlation with myocardial injury and LV remodeling and function in the acute phase of STEMI and after 3 months. +genetics_knock down_promote 31275638 hsa-mir-6802 ST Elevation Myocardial Infarction This study aims to evaluate (1) serum concentration of osteogenesis/osteolysis factors panel (Dickkopf-related protein 1 (DKK-1), TNF-alpha, N-terminal atrial natriuretic peptide (NT-proANP), thrombospondin-2 (TSP-2), osteoprotegerin (OPG), osteocalcin (OCN), osteopontin (OPN), fibroblast growth factor 23 (FGF-23), soluble receptor activator of nuclear factor-kappaB ligand (sRANKL), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), proprotein convertase subtilisin/kexin type 9 (PCSK9)), (2) serum expression levels of micro-RNA- (miR-) 24-1 and miR-6802, and (3) assess their correlation with myocardial injury and LV remodeling and function in the acute phase of STEMI and after 3 months. +circulation_biomarker_diagnosis_ns 31275442 hsa-mir-574 Heart Arrest 5p were measured by quantitative PCR in plasma samples collected 48 h after cardiac arrest. +other 31275362 hsa-mir-196a Stomach Neoplasms Only hsa-miR-196a-5p was differentially expressed between adjacent to cancer and gastric cancer tissues. +other 31275362 hsa-mir-200a Stomach Neoplasms Seven miRNAs were differentially expressed in both gastric cancer and adjacent regarding to non-cancerous tissues; among them, hsa-miR-200a-3p and hsa-miR5p have potential diagnostic value for early and advanced stages of the disease. +genetics_overexpression_suppress 31275360 hsa-mir-1 Colitis-Associated Neoplasms 3p overexpression, respectively, was used in the in vivo AOM/DSS-induced CAC model. +lncRNA target 31275360 hsa-let-7f Colitis-Associated Neoplasms Adenomatous polyposis coli (APC) was revealed as a new target of miR3p, and solute carrier family 9- subfamily A-member 9 (SLC9A9) and APC membrane recruitment protein 3 (AMER3) were suggested as two new targets for let-7f-5p. +genetics_overexpression_suppress 31275360 hsa-mir-223 Colitis-Associated Neoplasms 3p overexpression, respectively, was used in the in vivo AOM/DSS-induced CAC model. +other 31275358 hsa-mir-5003 Lupus Erythematosus, Systemic Additionally, miR-5003 expression was higher in B cells than in T cells from SLE patients, and a negative correlation between miR-5003 and ETS1 was found, especially in B cells with the T allele. +other 31275315 hsa-mir-155 Deficiency Diseases Using intravital multiphoton microscopy we analyzed the interaction of antigen presenting cells (APCs) and T cells after OVA immunization and found impaired complex formation when using miR-155 deficient CD4(+) T cells compared to wildtype CD4(+) T cells ex vivo. +other 31275315 hsa-mir-155 Sexually Transmitted Diseases, Viral Using transgenic/recombinant VSV expressing ovalbumin, we show that miR-155 is crucially involved in regulating the T helper cell response against this virus. Our experiments indicate that miR-155 in CD4(+) T cells controls their activation, proliferation, and cytokine production in vitro and in vivo upon immunization with OVA as well as during VSV viral infection. +other 31275315 hsa-mir-155 Autoimmune Diseases MicroRNA (miR) 155 has been implicated in the regulation of innate and adaptive immunity as well as autoimmune processes. +other 31275315 hsa-mir-155 Microphthalmia, syndromic 2 Our data provide the first evidence that miR-155 is required for efficient CD4(+) T cell activation during anti-viral defense by allowing robust APC-T cell interaction required for activation and cytokine production of virus specific T cells. +genetics_GWAS 31275170 hsa-mir-10a Infertility, Male Here, we show that genetically conditional overexpressed miR-10a in germ cells caused complete male sterility, characterized by meiotic arrested in germ cells. These findings facilitate our understanding of the roles of miRNA-10a in spermatogenesis and male fertility. +tissue_expression_ns 31275058 hsa-mir-155 DNA Repair-Deficiency Disorders In addition, DICER1 deficiency could lower the expression of multiple RA-related miRNAs such as miR-155. +tissue_expression_ns 31275058 hsa-mir-155 Arthritis, Rheumatoid In addition, DICER1 deficiency could lower the expression of multiple RA-related miRNAs such as miR-155. +genetics_GWAS 31274844 hsa-mir-188 Diabetes Mellitus, Type 2 Our findings indicate that the miR-3188 (rs7247237-C>T) polymorphism is associated with the incidence of vascular complications in Chinese patients with type 2 diabetes, likely due to its remarkable effect on miR-3188 expression. +genetics_GWAS 31274844 hsa-mir-188 Vascular Diseases Our findings indicate that the miR-3188 (rs7247237-C>T) polymorphism is associated with the incidence of vascular complications in Chinese patients with type 2 diabetes, likely due to its remarkable effect on miR-3188 expression. +other 31273952 hsa-mir-708 Breast Neoplasms In addition, the anti-type II diabetes drug metformin are found to be involved in the miR-708/CD47 signalling pathway. +genetics_overexpression_promote 31273950 hsa-mir-516a Breast Neoplasms Moreover, overexpression of miR-516a-3p inhibited cell growth, migration and invasion as well as epithelial-mesenchymal transition (EMT) of breast cancer cells, whereas reduced miR-516a-3p expression promoted breast cancer cell growth, migration, invasion and EMT. +circulation_biomarker_diagnosis_ns 31273939 hsa-mir-145 Arthritis, Rheumatoid 5p and miR-99b-5p in the plasma of ERA patients may characterize a severe form of the disease. +circulation_biomarker_diagnosis_ns 31273939 hsa-mir-143 Arthritis, Rheumatoid 5p and miR-99b-5p in the plasma of ERA patients may characterize a severe form of the disease. +circulation_biomarker_diagnosis_ns 31273939 hsa-mir-99b Arthritis, Rheumatoid 5p and miR-99b-5p in the plasma of ERA patients may characterize a severe form of the disease. +other 31273931 hsa-mir-938 Stomach Neoplasms CONCLUSION: rs12416605 appears to be involved in gastric cancer by affecting the regulatory function of MIR938 on genes related to this cancer type, particularly on CXCL12 posttranscriptional regulation. +other 31273931 hsa-mir-499b Stomach Neoplasms RESULTS: rs3746444:T>C, in the seed of MIR499A and mature MIR499B, associated with the cardia adenocarcinoma location; rs12416605:C>T, in the seed of MIR938, associated with the diffuse subtype; and rs2114358:T>C, in the precursor MIR1206, associated with the noncardia phenotype. +other 31273931 hsa-mir-499 Stomach Neoplasms RESULTS: rs3746444:T>C, in the seed of MIR499A and mature MIR499B, associated with the cardia adenocarcinoma location; rs12416605:C>T, in the seed of MIR938, associated with the diffuse subtype; and rs2114358:T>C, in the precursor MIR1206, associated with the noncardia phenotype. +other 31273931 hsa-mir-1206 Stomach Neoplasms RESULTS: rs3746444:T>C, in the seed of MIR499A and mature MIR499B, associated with the cardia adenocarcinoma location; rs12416605:C>T, in the seed of MIR938, associated with the diffuse subtype; and rs2114358:T>C, in the precursor MIR1206, associated with the noncardia phenotype. +other 31273931 hsa-mir-499a Stomach Neoplasms RESULTS: rs3746444:T>C, in the seed of MIR499A and mature MIR499B, associated with the cardia adenocarcinoma location; rs12416605:C>T, in the seed of MIR938, associated with the diffuse subtype; and rs2114358:T>C, in the precursor MIR1206, associated with the noncardia phenotype. +genetics_overexpression_promote 31273925 hsa-mir-214 Uterine Cervical Neoplasms Activation of the miR-214/EZH2 regulatory loop by overexpression of miR-214 or silencing of EZH2 reverses the roles of LINC01535 in promoting cervical canc;er cell growth, migration and invasion in vitro and cervical cancer xenograft growth in vivo. +lncRNA target 31273789 hsa-mir-496 Colorectal Neoplasms Next, a series of miR-496 mimics or inhibitor, or RASSF6 small interfering RNA (siRNA) introduced into CRC cells were applied to examine the effect of miR-496 on CRC cell viability, migration, and epithelial-mesenchymal transition (EMT). Our results confirmed that the miR-496/RASSF6 axis is involved in Wnt pathway-mediated tumor metastasis, highlighting its potential as a therapeutic target for CRC. +other 31273630 hsa-mir-451 hereditary diffuse gastric cancer The aim of this study was to investigate the effect of docetaxel (DOC) treatment on CD44+ cell frequency in human gastric cancer (GC) MKN-45 cell line and its effect on expression levels of SIRT1, CXCR4, microRNA (miR)-21, miR-451, and miR-34a that are closely correlated with the chemoresistance or self-renewal of cancer stem cells (CSCs). +other 31273630 hsa-mir-21 Corneal dystrophy, epithelial basement membrane The aim of this study was to investigate the effect of docetaxel (DOC) treatment on CD44+ cell frequency in human gastric cancer (GC) MKN-45 cell line and its effect on expression levels of SIRT1, CXCR4, microRNA (miR)-21, miR-451, and miR-34a that are closely correlated with the chemoresistance or self-renewal of cancer stem cells (CSCs). CONCLUSION: DOC treatment affected CD44+ cell frequency in MKN-45 cell line and induced significant changes in the expression of SIRT1, CXCR4, miR-21, miR-451, and miR-34a that are implicated in stemness and chemo-radioresistance, which might offer new insights for future GC therapies. +other 31273630 hsa-mir-34a Corneal dystrophy, epithelial basement membrane The aim of this study was to investigate the effect of docetaxel (DOC) treatment on CD44+ cell frequency in human gastric cancer (GC) MKN-45 cell line and its effect on expression levels of SIRT1, CXCR4, microRNA (miR)-21, miR-451, and miR-34a that are closely correlated with the chemoresistance or self-renewal of cancer stem cells (CSCs). CONCLUSION: DOC treatment affected CD44+ cell frequency in MKN-45 cell line and induced significant changes in the expression of SIRT1, CXCR4, miR-21, miR-451, and miR-34a that are implicated in stemness and chemo-radioresistance, which might offer new insights for future GC therapies. +other 31273630 hsa-mir-34a hereditary diffuse gastric cancer The aim of this study was to investigate the effect of docetaxel (DOC) treatment on CD44+ cell frequency in human gastric cancer (GC) MKN-45 cell line and its effect on expression levels of SIRT1, CXCR4, microRNA (miR)-21, miR-451, and miR-34a that are closely correlated with the chemoresistance or self-renewal of cancer stem cells (CSCs). +other 31273630 hsa-mir-451 Corneal dystrophy, epithelial basement membrane The aim of this study was to investigate the effect of docetaxel (DOC) treatment on CD44+ cell frequency in human gastric cancer (GC) MKN-45 cell line and its effect on expression levels of SIRT1, CXCR4, microRNA (miR)-21, miR-451, and miR-34a that are closely correlated with the chemoresistance or self-renewal of cancer stem cells (CSCs). CONCLUSION: DOC treatment affected CD44+ cell frequency in MKN-45 cell line and induced significant changes in the expression of SIRT1, CXCR4, miR-21, miR-451, and miR-34a that are implicated in stemness and chemo-radioresistance, which might offer new insights for future GC therapies. +other 31273630 hsa-mir-21 hereditary diffuse gastric cancer The aim of this study was to investigate the effect of docetaxel (DOC) treatment on CD44+ cell frequency in human gastric cancer (GC) MKN-45 cell line and its effect on expression levels of SIRT1, CXCR4, microRNA (miR)-21, miR-451, and miR-34a that are closely correlated with the chemoresistance or self-renewal of cancer stem cells (CSCs). +lncRNA target 31273599 hsa-mir-4529 Stomach Neoplasms 5p/ROCK2 regulatory axis that contributes to the tumorigenesis of gastric cancer and provided potential therapeutic targets for precise gastric cancer treatment. +lncRNA target 31273338 hsa-mir-513a Nasopharyngeal Neoplasms Further, MRVI1-AS1 upregulated ATF3 (activating transcription factor 3) by simultaneously inhibiting miR-513a-5p (microRNA-513a-5p) and miR-27b-3p expression levels to increase NPC paclitaxel chemosensitivity. +other 31273251 hsa-mir-26b Leukemia, Myelogenous, Chronic, BCR-ABL Positive This work aimed to correlate the expression levels of 3 miRs, miR-21, miR-26b and miR-451, with response to TKI treatment in CML patients. +other 31273251 hsa-mir-451 Leukemia, Myelogenous, Chronic, BCR-ABL Positive This work aimed to correlate the expression levels of 3 miRs, miR-21, miR-26b and miR-451, with response to TKI treatment in CML patients. +other 31273251 hsa-mir-21 Leukemia, Myelogenous, Chronic, BCR-ABL Positive This work aimed to correlate the expression levels of 3 miRs, miR-21, miR-26b and miR-451, with response to TKI treatment in CML patients. +lncRNA target 31273221 hsa-mir-107 Colorectal Neoplasms Together, our study identifies a novel function of miR-103/107 in promoting colorectal cancer stemness by targeting Axin2 and elucidates the clinical relevance and prognostic value of this axis in colorectal cancer. +lncRNA target 31273221 hsa-mir-103 Colorectal Neoplasms Together, our study identifies a novel function of miR-103/107 in promoting colorectal cancer stemness by targeting Axin2 and elucidates the clinical relevance and prognostic value of this axis in colorectal cancer. +lncRNA target 31273190 hsa-mir-186 Colorectal Neoplasms All in all, our observations demonstrated that SNHG14 serves as a facilitator in CRC through targeting EZH2-repressed EPHA7 by enhancing EZH2 via recruiting FUS and absorbing miR +other 31273188 hsa-mir-326 Squamous Cell Carcinoma of Head and Neck Rescue experiments revealed that enforced expression of miR-326 attenuated the promotive effect of PCAT1 on ESCC cell growth. Thus, our data indicate that PCAT1 promotes ESCC cell proliferation by sponging miR-326 and may serve as a non-invasive biomarker for ESCC. +other 31273058 hsa-mir-15a Pulmonary Fibrosis We aimed to explore the relationship between miR-15a and lncRNA PFAR and its function in pulmonary fibrosis. +circulation_biomarker_diagnosis_ns 31273056 hsa-mir-222 Breast Neoplasms We found that miR-222 was highly expressed in patients' serum and DOX-resistant cell line MCF +other 31273052 hsa-mir-155 Thrombocytopenia 3p were significantly decreased in Tregs from patients with ITP compared with healthy controls. +other 31273052 hsa-mir-146b Thrombocytopenia 3p were significantly decreased in Tregs from patients with ITP compared with healthy controls. +other 31273052 hsa-mir-142 Thrombocytopenia 3p were significantly decreased in Tregs from patients with ITP compared with healthy controls. +lncRNA target 31272362 hsa-mir-491 Lung Neoplasms CONCLUSION: These findings suggest that Rh2 exerts anti-metastasis activity in the hypoxic tumor microenvironment in lung adenocarcinoma cells via mir-491. +lncRNA target 31272285 hsa-mir-145 Diabetic Retinopathy Abbreviations: DR: diabetic retinopathy; RGCs: retinal ganglion cells; miR +genetics_overexpression_promote 31272074 hsa-mir-340 Glioblastoma Overexpression of miR +genetics_overexpression_suppress 31272072 hsa-mir-26a Brain Injuries, Traumatic Collectively, these results indicate that miRNA-26a-5p overexpression may be a key factor governing the improved fracture healing observed in TBI patients after the downregulation of PTEN and PI3K/AKT signaling. Upregulation of miRNA-26a-5p may therefore be a promising therapeutic strategy for promoting fracture healing. +genetics_overexpression_suppress 31272072 hsa-mir-26a Fractures, Bone Collectively, these results indicate that miRNA-26a-5p overexpression may be a key factor governing the improved fracture healing observed in TBI patients after the downregulation of PTEN and PI3K/AKT signaling. Upregulation of miRNA-26a-5p may therefore be a promising therapeutic strategy for promoting fracture healing. +genetics_knock down_promote 31271703 hsa-mir-128 Ovarian Neoplasms Knockdown of HOXB8 abolished the effects of miR-128 inhibitor on ovarian cancer cell proliferation and paclitaxel sensitivity. +lncRNA target 31271496 hsa-mir-522 Carcinoma, Endometrioid In conclusion, our observations demonstrated that miR-522 accelerated the progression of endometrial carcinoma by inhibiting MAOB, which might lead to a novel therapeutic therapy for endometrial carcinoma. +lncRNA target 31271056 hsa-mir-145 Uterine Cervical Neoplasms The miR-145/ FSCN1 axis contributes to the progression of cervical cancer by inhibition of cervical cancer cell proliferation. +circRNA target 31270953 hsa-mir-1182 Prostatic Neoplasms FOXP4 regulatory loop may be a promising therapeutic target for prostate cancer intervention. +other 31270251 hsa-mir-149 Squamous Cell Carcinoma of Head and Neck 5p and expression levels of SP1 and STAT3 proteins in tumor tissues and adjacent normal tissues of TSCC patients were ascertained.Results: Carrying the SP1 rs1353058818 locus deletion allele was a high risk factor for TSCC (OR = 2.997, 95% CI: 1.389-6.466, P = 0.003). +other 31270251 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck 5p and expression levels of SP1 and STAT3 proteins in tumor tissues and adjacent normal tissues of TSCC patients were ascertained.Results: Carrying the SP1 rs1353058818 locus deletion allele was a high risk factor for TSCC (OR = 2.997, 95% CI: 1.389-6.466, P = 0.003). +circulation_biomarker_diagnosis_up 31270050 hsa-mir-23a Carcinoma, Non-Small-Cell Lung Compared with those in the control group, miRNA-23a level was significantly increased while miRNA-451 was significantly down-regulated in the tumor tissues and plasma of NSCLC patients. +circulation_biomarker_diagnosis_up 31270050 hsa-mir-451 Carcinoma, Non-Small-Cell Lung Compared with those in the control group, miRNA-23a level was significantly increased while miRNA-451 was significantly down-regulated in the tumor tissues and plasma of NSCLC patients. +circulation_biomarker_diagnosis_up 31270050 hsa-mir-345 Carcinoma, Non-Small-Cell Lung Compared with those in the control group, miRNA-23a level was significantly increased while miRNA-451 was significantly down-regulated in the tumor tissues and plasma of NSCLC patients. +other 31270041 hsa-mir-181b Carcinoma, Squamous Cell IPA analysis showed that transcription factors (GATA4, RELA, YBX1, TP63 and MBD2), cytokines (WNT5A and IL1A) and microRNAs (miR-34a, miR-181b and miR-15a) differed significantly between LUAD and LUSC. Analysis of the clinical samples showed an increased expression of miR-181b-5p and the down-regulation of WNT5A, which could be used as molecular markers for the diagnosis of LUSC. +lncRNA target 31270041 hsa-mir-15a Adenocarcinoma of Lung miR-34a with IL-1A, miR-15a with YBX1, and miR-181b with WNT5A and MBD2 could serve as the paired microRNA and mRNA targets for differential diagnosis of NSCLC subtypes. +other 31270041 hsa-mir-181b Adenocarcinoma of Lung IPA analysis showed that transcription factors (GATA4, RELA, YBX1, TP63 and MBD2), cytokines (WNT5A and IL1A) and microRNAs (miR-34a, miR-181b and miR-15a) differed significantly between LUAD and LUSC. Analysis of the clinical samples showed an increased expression of miR-181b-5p and the down-regulation of WNT5A, which could be used as molecular markers for the diagnosis of LUSC. +lncRNA target 31270041 hsa-mir-15a Carcinoma, Squamous Cell miR-34a with IL-1A, miR-15a with YBX1, and miR-181b with WNT5A and MBD2 could serve as the paired microRNA and mRNA targets for differential diagnosis of NSCLC subtypes. +lncRNA target 31270041 hsa-mir-34a Adenocarcinoma of Lung miR-34a with IL-1A, miR-15a with YBX1, and miR-181b with WNT5A and MBD2 could serve as the paired microRNA and mRNA targets for differential diagnosis of NSCLC subtypes. +lncRNA target 31270041 hsa-mir-34a Carcinoma, Squamous Cell miR-34a with IL-1A, miR-15a with YBX1, and miR-181b with WNT5A and MBD2 could serve as the paired microRNA and mRNA targets for differential diagnosis of NSCLC subtypes. +other 31270041 hsa-mir-181 Adenocarcinoma of Lung IPA analysis showed that transcription factors (GATA4, RELA, YBX1, TP63 and MBD2), cytokines (WNT5A and IL1A) and microRNAs (miR-34a, miR-181b and miR-15a) differed significantly between LUAD and LUSC. Analysis of the clinical samples showed an increased expression of miR-181b-5p and the down-regulation of WNT5A, which could be used as molecular markers for the diagnosis of LUSC. +other 31270041 hsa-mir-181 Carcinoma, Squamous Cell IPA analysis showed that transcription factors (GATA4, RELA, YBX1, TP63 and MBD2), cytokines (WNT5A and IL1A) and microRNAs (miR-34a, miR-181b and miR-15a) differed significantly between LUAD and LUSC. Analysis of the clinical samples showed an increased expression of miR-181b-5p and the down-regulation of WNT5A, which could be used as molecular markers for the diagnosis of LUSC. +lncRNA target 31270028 hsa-mir-454 Uterine Cervical Neoplasms Bioinformatics analysis predicted that tripartite motif-containing 3 (TRIM3), a tumor suppressor gene in cervical cancer, is a promising target of miR +exosome 31269723 hsa-mir-21 Glioblastoma We found that GBM-associated macrophages (GAMs) secreted exosomes which were enriched with oncomiR-21. +other 31269677 hsa-mir-195 Ichthyosis, Lamellar 3p, miR-30a-5p, and miR-10b-5p were up-regulated after HI. +other 31269677 hsa-mir-10b Ichthyosis, Lamellar 3p, miR-30a-5p, and miR-10b-5p were up-regulated after HI. +other 31269677 hsa-mir-197 Ichthyosis, Lamellar 3p, miR-30a-5p, and miR-10b-5p were up-regulated after HI. +other 31269677 hsa-mir-139 Ichthyosis, Lamellar 3p, miR-30a-5p, and miR-10b-5p were up-regulated after HI. +circulation_biomarker_diagnosis_up 31269677 hsa-mir-143 Ichthyosis, Lamellar 3p in young and healthy athletes are consistent with an important role of this particular miRNA in metabolic processes during (here) artificial blood flow restriction. +lncRNA target 31269585 hsa-mir-152 Prostatic Neoplasms The results of LNCediting and qRT-PCR suggest that HOTAIR is negatively correlated with the expression of miR-152, and is involved in the regulation of miR-152 expression in prostate cancer. Conclusion: FOXR2 up-regulation can promote the proliferation and inhibit the apoptosis of prostate cancer cells because that HOTAIR restrains the expression of miR-152. +lncRNA target 31269584 hsa-mir-218 Colorectal Neoplasms LINC00339 expression was negatively correlated with miR-218 expression in colorectal cancer tissues (P<0.05). LINC00339 promotes proliferation, and suppresses apoptosis of colorectal cancer cells via downregulating miR-218. +genetics_GWAS 31269493 hsa-let-7 Esophageal Squamous Cell Carcinoma METHODS: A case-control study including 494 ESCC patients and 494 controls was carried out to investigate the genetic susceptibility of 4 microRNA-binding site SNPs (rs712 in the binding site of KRAS to let-7, rs8904 in the binding site of NFBIA to mir-507, rs3738894 in the binding site of protein kinase C epsilon to mir-218, rs701848 in the binding site of phosphatase and tensin to mir-1304) as well as the interactions of gene-environment in the development of ESCC. +genetics_GWAS 31269493 hsa-mir-507 Esophageal Squamous Cell Carcinoma METHODS: A case-control study including 494 ESCC patients and 494 controls was carried out to investigate the genetic susceptibility of 4 microRNA-binding site SNPs (rs712 in the binding site of KRAS to let-7, rs8904 in the binding site of NFBIA to mir-507, rs3738894 in the binding site of protein kinase C epsilon to mir-218, rs701848 in the binding site of phosphatase and tensin to mir-1304) as well as the interactions of gene-environment in the development of ESCC. +genetics_GWAS 31269493 hsa-mir-218 Esophageal Squamous Cell Carcinoma METHODS: A case-control study including 494 ESCC patients and 494 controls was carried out to investigate the genetic susceptibility of 4 microRNA-binding site SNPs (rs712 in the binding site of KRAS to let-7, rs8904 in the binding site of NFBIA to mir-507, rs3738894 in the binding site of protein kinase C epsilon to mir-218, rs701848 in the binding site of phosphatase and tensin to mir-1304) as well as the interactions of gene-environment in the development of ESCC. +genetics_GWAS 31269493 hsa-mir-1304 Esophageal Squamous Cell Carcinoma METHODS: A case-control study including 494 ESCC patients and 494 controls was carried out to investigate the genetic susceptibility of 4 microRNA-binding site SNPs (rs712 in the binding site of KRAS to let-7, rs8904 in the binding site of NFBIA to mir-507, rs3738894 in the binding site of protein kinase C epsilon to mir-218, rs701848 in the binding site of phosphatase and tensin to mir-1304) as well as the interactions of gene-environment in the development of ESCC. +lncRNA target 31269463 hsa-mir-126 Anovulation Both SMAD4 and miR-126* have been proven to be involved in granulosa cell (GC) apoptosis and even follicular atresia, through commonly regulating follicle-stimulating hormone receptor (FSHR), the FSH-specific transmembrane receptor of GCs. +other 31269432 hsa-mir-23b Breast Neoplasms A global transcription analysis in ETR cells reveals a downregulation of the neutral and basic amino acid transporter SLC6A14 governed by enhanced miR-23b-3p expression, resulting in impaired amino acid metabolism. +genetics_overexpression_suppress 31269290 hsa-mir-139 Prostatic Neoplasms Overexpression of miR-139 in prostate cancer cells led to a significant reduction in cell proliferation and migration compared with control cells, with cells arrested in G2 of cell cycle. +other 31268978 hsa-mir-27a Carcinoma, Intraductal, Noninfiltrating Gastrin re-expression in the PanINs was mediated by miR-27a. +genetics_overexpression_promote 31268161 hsa-mir-1 Stomach Neoplasms In addition, overexpression of sorcin could partially reverse the effect of miR1 in MDR GC cells. +other 31267617 hsa-mir-26a Chemical and Drug Induced Liver Injury, Chronic In the present study, we investigated the relationship between microRNA (miRNA)-26a and ALR in the Huh7 cell line and adipose tissue-derived mesenchymal cells from chronic liver disease patients and healthy individuals. +lncRNA target 31267540 hsa-mir-133b Prostatic Neoplasms Direct interactions between miR-133b and SNHG12 have been found and SNHG12 acts as an oncogene to promote tumorigenesis of PCa by sponging tumor suppressor gene miR-133b. +lncRNA target 31267533 hsa-mir-26a Cartilage Diseases In addition, CTGF was determined as a direct target gene of miR-26a, and upregulation of miR-26a inhibited CTGF expression in cartilage tissues of RA rats. +lncRNA target 31267533 hsa-mir-26a Arthritis, Rheumatoid In addition, CTGF was determined as a direct target gene of miR-26a, and upregulation of miR-26a inhibited CTGF expression in cartilage tissues of RA rats. +lncRNA target 31267531 hsa-mir-10b Esophageal Squamous Cell Carcinoma Inactivation of AKT/mTOR/p70S6K by AKT inhibitor (GSK690693) attenuated miR-10b-induced DDP resistance in esophageal cancer cells. +lncRNA target 31267381 hsa-mir-135a Pancreatic Carcinoma Conclusion DANCR promoted proliferation and invasion through the regulating of miR-135a / NLRP3 axis in pancreatic cancer cell. +lncRNA target 31267263 hsa-mir-4319 Carcinoma, Non-Small-Cell Lung GNAS-AS1 promoted macrophage M2 polarization and NSCLC cell progression via directly inhibiting miR-4319, which could target N-terminal EF-hand calcium binding protein 3 (NECAB3) to inhibit its expression. GNAS-AS1/miR-4319/NECAB3 axis promotes tumor progression of NSCLC by altering macrophage polarization. +genetics_overexpression_promote 31266828 hsa-mir-130b Prostatic Neoplasms miR-130b is a significant contributor to prostate cancer racial disparity as its overexpression is a risk factor for poor prognosis in AA patients with prostate cancer. +transcription factor target 31266808 hsa-mir-101b Diabetic Nephropathies Furthermore, in kidneys from rodent models of DN, fibrotic genes, miR-101b, and H3K27me3 demethylases are up-regulated, whereas Ezh2 protein levels as well as enrichment of Ezh2 and H3K27me3 at target genes are decreased, demonstrating in vivo relevance. +epigenetics 31266372 hsa-mir-200a Breast Neoplasms FEN1 mediates miR-200a methylation and promotes breast cancer cell growth via MET and EGFR signaling. +transcription factor target 31266356 hsa-mir-21 Spinal Cord Ischemia Silencing miR-21 induces polarization of astrocytes to the A2 phenotype and improves the formation of synapses by targeting glypican 6 via the signal transducer and activator of transcription-3 pathway after acute ischemic spinal cord injury. +exosome 31265948 hsa-mir-203 Nasopharyngeal Carcinoma Our study also provides a rationale for the use of exo-LMP1 or exosomal miR-203 (exo-miR203) in EBV-targeted therapy by aspirin in invasive NPC. +lncRNA target 31265855 hsa-mir-374a Myocardial Reperfusion Injury SIGNIFICANCE: Taken together, our study suggests that miR-374a-5p may have protective effects against cardiac I/R injury in vivo, and H/R injury in vitro, thereby providing novel insights into the molecular mechanisms associated with ischemia/reperfusion injury and a potential novel therapeutic target. +lncRNA target 31264507 hsa-mir-15a Cataract, Age-Related Introduction: In order to better understand the role of hsa-miR-15a in the pathogenesis of age-related cataracts, we hypothesised altered expression, and of target anti-apoptotic genes, BCL-2 and MCL-1, in lens epithelial cells amongst age-related cataract patients.Material and methods: Reverse transcription quantitative polymerase chain reaction (RT-qPCR) quantified the expression of hsa-miR-15a and the target genes BCL-2 and MCL-1 in lens epithelial cells of 120 age-related cataract patients (40 patients with cortical cataracts, 40 patients with nuclear cataracts and 40 patients with posterior subcapsular cataracts) and 40 controls. +transcription factor target 31264490 hsa-mir-145 Asthma 5p promoted the HDM-induced release of chemokines and inflammatory factors and epithelial barrier dysfunction, and suppressed epithelial repair by directly targeting KIF3A. +lncRNA target 31264214 hsa-mir-26a Cerebral Palsy This study is launched to investigate the effect of lentivirus-mediated microRNA-26a (miR-26a)-modified neural stem cells (NSCs) in brain injury in rats with cerebral palsy (CP). Our study suggests that miR-26a-modified NSCs mediated by lentivirus can improve brain injury, inhibit apoptosis of brain cells and activation of astrocytes in CP rats. +lncRNA target 31264214 hsa-mir-26a Brain Injuries This study is launched to investigate the effect of lentivirus-mediated microRNA-26a (miR-26a)-modified neural stem cells (NSCs) in brain injury in rats with cerebral palsy (CP). Our study suggests that miR-26a-modified NSCs mediated by lentivirus can improve brain injury, inhibit apoptosis of brain cells and activation of astrocytes in CP rats. +lncRNA target 31264206 hsa-mir-7 Myocardial Infarction CONCLUSION: Our findings disclosed that ANRIL plays a protective part in hypoxia-induced H9c2 cell injury via modulating the miR5p/SIRT1 axis, suggesting the great potential of ANRIL as a protective target for AMI. +genetics_GWAS 31264164 hsa-mir-146a Pre-Eclampsia In conclusion, according to logistic regression analysis the maternal/placental miR-146a rs2910164 G/C polymorphism was associated with PE and/or severe PE risk. +genetics_GWAS 31264164 hsa-mir-149 Pre-Eclampsia The effect of miR-146a rs2910164 and miR-149 rs2292832 polymorphisms on preeclampsia susceptibility. +lncRNA target 31264061 hsa-mir-196 Breast Neoplasms Currently, ADPGK-AS1 acted as a competing endogenous RNA (ceRNA) via modulating miR-3196/OTX1 axis in BC. +other 31263422 hsa-mir-210 Trophoblastic Neoplasms miR-210, a small non-coding RNA, is increased in the preeclamptic placenta. +other 31263200 hsa-mir-21 Colorectal Neoplasms In conclusion, faecal miR-21, miR-92a and their combination are promising non-invasive biomarkers for faecal-based CRC screening. +other 31263200 hsa-mir-92a Colorectal Neoplasms In conclusion, faecal miR-21, miR-92a and their combination are promising non-invasive biomarkers for faecal-based CRC screening. +other 31263200 hsa-mir-21 Colorectal Adenocarcinoma In conclusion, faecal miR-21, miR-92a and their combination are promising non-invasive biomarkers for faecal-based CRC screening. +other 31263200 hsa-mir-92a Colorectal Adenocarcinoma In conclusion, faecal miR-21, miR-92a and their combination are promising non-invasive biomarkers for faecal-based CRC screening. +transcription factor target 31263091 hsa-mir-149 Intervertebral disc disease CONCLUSIONS miR-149 can inhibit the inflammatory response mediated by LPS in NP cells, and might be a potential target for the treatment of IDD. +transcription factor target 31262974 hsa-mir-193b Lung Neoplasms Both strands of miR-193b were down-regulated in brain metastatic lung cancer cells and in tissues from lung cancer patients. Our results demonstrate miR-193b is a dual-strand tumor suppressor and a novel therapeutic target for lung cancer. +lncRNA target 31262291 hsa-mir-374a Palatal Neoplasms CONCLUSIONS: Our results indicate that miR-374a-5p, miR3p, and miR-133b regulate expression of genes that are involved in the etiology of human CP, providing insight into the association between CP-associated genes and potential targets of miRNAs in palate development. +lncRNA target 31262291 hsa-mir-133b isolated cleft palate 3p, and miR-133b regulate expression of genes that are involved in the etiology of human CP, providing insight into the association between CP-associated genes and potential targets of miRNAs in palate development. +lncRNA target 31262291 hsa-mir-4680 isolated cleft palate 3p, and miR-133b regulate expression of genes that are involved in the etiology of human CP, providing insight into the association between CP-associated genes and potential targets of miRNAs in palate development. +lncRNA target 31262291 hsa-mir-374a isolated cleft palate 3p, and miR-133b regulate expression of genes that are involved in the etiology of human CP, providing insight into the association between CP-associated genes and potential targets of miRNAs in palate development. +lncRNA target 31262291 hsa-mir-4680 Palatal Neoplasms CONCLUSIONS: Our results indicate that miR-374a-5p, miR3p, and miR-133b regulate expression of genes that are involved in the etiology of human CP, providing insight into the association between CP-associated genes and potential targets of miRNAs in palate development. +lncRNA target 31262291 hsa-mir-133b Palatal Neoplasms CONCLUSIONS: Our results indicate that miR-374a-5p, miR3p, and miR-133b regulate expression of genes that are involved in the etiology of human CP, providing insight into the association between CP-associated genes and potential targets of miRNAs in palate development. +lncRNA target 31262262 hsa-mir-16 Fibrosis WWC2-AS1 more potently boosted FGF2 expression via reducing miR-16, and WWC2-AS1 shRNA remarkably inhibited FGF2 associated proliferation, migration, invasion and fibrosis of radiation treatment in vitro, further demonstrating physical interaction between miR-16 and WWC2-AS1 in radiation-induced fibrosis progress. +lncRNA target 31262262 hsa-mir-16 Radiation Injuries WWC2-AS1 more potently boosted FGF2 expression via reducing miR-16, and WWC2-AS1 shRNA remarkably inhibited FGF2 associated proliferation, migration, invasion and fibrosis of radiation treatment in vitro, further demonstrating physical interaction between miR-16 and WWC2-AS1 in radiation-induced fibrosis progress. +other 31262262 hsa-mir-16 Rift Valley Fever CONCLUSIONS: WWC2-AS1 was highly expressed in RIF, may function as a ceRNA in the regulation of FGF2 by binding miR-16. +circulation_biomarker_diagnosis_down 31261511 hsa-mir-101 Urinary Bladder Neoplasms The cut-off value for serum miR-101 in bladder cancer diagnosis was 1.645, with a sensitivity of 82.0% and a specificity of 80.9%.MiR-101 is decreased in bladder cancer patients, and shows negative association with aggressive clinical characteristics. +other 31261033 hsa-mir-221 Myocardial Infarction Reduced myocardial miR-221 expression is associated with severe cardiac fibrosis in heart failure patients. +genetics_knock down_promote 31261026 hsa-mir-17 Colorectal Neoplasms 5p showed suppressive role on cell viability, invasion, migration, and multi-drug resistance in HCT116/5-FU and SW480/5-FU cells, which could be abolished by HOTAIRM1 knockdown. +genetics_overexpression_promote 31260797 hsa-mir-675 Stomach Neoplasms Overexpression of miR-675 in AGS cells notably promoted cell proliferation, migration and invasion, whilst down-regulation of miR-675 in SGC-7901 cells gained the opposite results. +other 31260649 hsa-mir-149 Diabetes Mellitus The therapeutic potential of miR5p in the treatment of DM still requires further detailed investigations. +other 31260146 hsa-mir-2703 Congenital Abnormalities The nymphs showed an obvious moulting defect phenotype, lower survival rate and significantly reduced chitin content after miR-2703 feeding or injection. +circulation_biomarker_diagnosis_ns 31259424 hsa-mir-1 Carcinoma, Renal Cell Finally, miR5p level in circulating EVs of RCC patients with progressive disease (PD) during sorafenib therapy was higher when compared to that in the pretherapy status. +transcription factor target 31259152 hsa-mir-149 Breast Neoplasms Thus, our data indicate that UA can reverse PTX resistance by targeting the miRNA +other 31258881 hsa-mir-9 Carcinoma, Hepatocellular To investigate the mechanisms by which tumor vasculogenesis and progression following AATs, we transfected microRNA (miR)-9 into human umbilical vein endothelial cells (HUVECs) to mimic the tumor-associated endothelial cells in hepatocellular carcinoma and simulated the AATs in vitro and in vivo. +lncRNA target 31258782 hsa-mir-1226 Carcinoma, Hepatocellular 3p promotes sorafenib sensitivity of HCC through downregulation of DUSP4 expression, and targeting miR +lncRNA target 31258780 hsa-mir-519d Squamous Cell Carcinoma of Head and Neck Using bioinformatics and biological approaches, we showed that miR-519d directly targeted matrix metalloproteinase-3 (MMP3), which might account for the underlying mechanism involved in the miR-519d mediated suppression of OSCC progression. +lncRNA target 31258770 hsa-mir-101 Burkitt Lymphoma 3p advances sensitivity of BUC to CDDP through targeted silencing EZH2. +other 31258761 hsa-mir-490 Carcinoma, Hepatocellular Survival analysis identified nine genes (hsa-miR-137, hsa-miR-490, BIRC5, TOP2A, CDC25C, IGF2BP1, IQGAP3, NCAPG and VIPR1) with significant influence on prognosis of HCC patients. +other 31258761 hsa-mir-137 Carcinoma, Hepatocellular Survival analysis identified nine genes (hsa-miR-137, hsa-miR-490, BIRC5, TOP2A, CDC25C, IGF2BP1, IQGAP3, NCAPG and VIPR1) with significant influence on prognosis of HCC patients. +lncRNA target 31258758 hsa-mir-221 Carcinoma, Hepatocellular 3p and target genes, especially CBFB, UBE2N, may serve as prognostic predictors for HCC. +lncRNA target 31258758 hsa-mir-222 Carcinoma, Hepatocellular 3p and target genes, especially CBFB, UBE2N, may serve as prognostic predictors for HCC. +transcription factor target 31258753 hsa-mir-199a Carcinoma, Non-Small-Cell Lung Then, miR-199a-5p played a tumor suppression role via directly targeting MAP3K11 gene in non-small cell lung cancer (NSCLC). +transcription factor target 31258713 hsa-mir-155 Arthritis, Rheumatoid Inhibition of miR-155 may be an effective treatment for RA through regulation of the Wnt signaling pathway to reduce cell apoptosis and enhance cell viability. +genetics_knock down_promote 31258712 hsa-mir-25 Glioma miR-25 upregulation exhibited an association with glioma progression, and the knockdown of miR-25 significantly inhibited glioma cell proliferation and migration. +genetics_overexpression_promote 31258704 hsa-mir-490 Glioma Overexpression of miR +transcription factor target 31258702 hsa-mir-144 Glaucoma The over-expression of miR3p promotes proliferation and invasion of HTMCs by inhibiting the expression of FN-1 in inoxidative stress HTMCs, and is a potential target for glaucoma treatment. +transcription factor target 31258702 hsa-mir-144 Osteochondrodysplasias The over-expression of miR3p promotes proliferation and invasion of HTMCs by inhibiting the expression of FN-1 in inoxidative stress HTMCs, and is a potential target for glaucoma treatment. +genetics_overexpression_suppress 31258693 hsa-mir-620 Triple Negative Breast Neoplasms A negative correlation was identified between miR-620 and DCTD mRNA expression levels in patients with TNBC. The present results demonstrated that overexpression of miR-620 could contribute to the development of gemcitabine resistance in patients with TNBC via the direct downregulation of DCTD. +circulation_biomarker_diagnosis_up 31258687 hsa-mir-19b Diabetes Mellitus, Type 2 In conclusion, the decrease in miR-19b expression can improve the therapeutic effect of Exendin-4 on NOD, control blood glucose effectively and improve inflammatory response and immune function, as well as reduce islet cell injury. +circulation_biomarker_diagnosis_ns 31258685 hsa-mir-202 Mouth Neoplasms Receiver operating characteristic analysis was carried out to explore the diagnostic value of serum miR-202 for oral cancer. +genetics_overexpression_promote 31258684 hsa-mir-485 Glioblastoma 3p inhibited GBM cell proliferation and migration whilst overexpression of RNF135 reversed this effect. +transcription factor target 31258681 hsa-mir-152 Liver Cirrhosis These data provided insight into the potential function of miR-152 as an anti-fibrotic therapy through the modulation of Gli3. +other 31258677 hsa-mir-18 Diabetes Mellitus The purpose of the present study was to explore the role of microRNA (miR)-18 in DM and its underlying mechanisms, providing novel ideas for the treatment of the disease. +other 31258667 hsa-mir-877 Bone Diseases In conclusion, the results of the present study suggest that the miR3p/Smad7 axis is associated with the osteoblastic differentiation of MC3T3-E1 cells and may indicate a potential therapeutic approach for osteogenesis disorders. +circulation_biomarker_diagnosis_ns 31258665 hsa-mir-206 Sepsis The present study investigated the relationship between connexin 43 (Cx43) expression in alveolar type II epithelial cells (ATII) and alveolar air-blood barrier permeability, and the effect of microRNA-206 (miR-206) on the expression of Cx43 in sepsis-induced acute lung injury. +circulation_biomarker_diagnosis_ns 31258665 hsa-mir-206 Acute Lung Injury The present study investigated the relationship between connexin 43 (Cx43) expression in alveolar type II epithelial cells (ATII) and alveolar air-blood barrier permeability, and the effect of microRNA-206 (miR-206) on the expression of Cx43 in sepsis-induced acute lung injury. +circulation_biomarker_diagnosis_up 31258660 hsa-mir-204 Pulpitis The present study demonstrated that MMP9 expression in pulp tissues, blood and saliva from children with pulpitis and Hp infection in the stomach was upregulated, while miR-204 expression was downregulated. +genetics_knock down_promote 31258654 hsa-mir-16 Stomach Neoplasms Furthermore, knockdown of miR-16 impaired the inhibitory effects on GC cell proliferation and migration induced by downregulation of SNHG12. +other 31258652 hsa-mir-183 Myocardial Infarction miR-183 may therefore be further developed for clinical use to benefit patients with coronary artery diseases. +lncRNA target 31258640 hsa-mir-15b Peripheral Arterial Disease The current study aimed to determine the role of microRNA-15b (miR-15b) in the development of PAD and its associated mechanisms. In conclusion, the data indicated that miR-15b participated in the occurrence and development of PAD by modulating hVSMC proliferation, apoptosis and migration via the regulation of IGF1R expression. +lncRNA target 31258634 hsa-mir-122 Cholangiocarcinoma In conclusion, the present study demonstrates that the lncRNA UCA1 promotes ICC cell proliferation and invasion at least in part by targeting miR-122, suggesting that the UCA1/miR-122 interaction may become a potential therapeutic target for the treatment of ICC. +lncRNA target 31258546 hsa-mir-486 Pancreatic Carcinoma miR-486 has been reported to be involved in diverse types of malignant tumors; however, its role in pancreatic cancer remains unclear. Inhibition of miR-486 might be a novel therapy for pancreatic cancer. +lncRNA target 31258013 hsa-mir-34a Ear Neoplasms For example, ectopic expression of microRNA-34a (miR-34a), a tumor suppressor gene that is a direct transcriptional target of p53 and thus is reduced in p53 mutant tumors, has clear effects on cell proliferation and survival in murine models of cancer. +genetics_overexpression_suppress 31257935 hsa-mir-25 Acrodermatitis enteropathica NEFL as a neoteric target gene of miR-25 was predicated, and overexpressed NEFL annulled the functions of EMO in hypoxia-injured cells. +lncRNA target 31257923 hsa-mir-15a Wilms Tumor Then, the combination of miR-15a inhibitor abolished the inhibiting effect of si-SNHG6 on WT progression. In summary, SNHG6 is an oncogene of WT development by targeting miR-15a. +lncRNA target 31257621 hsa-mir-156 cone-rod dystrophy 6 The altered CR phenotype of crd1 was simulated by target mimicry of miR156, suggesting that this defect is due to the disruption of miR156 regulatory pathways. +lncRNA target 31257538 hsa-mir-21 Melanoma The present findings suggested that miR21 could inhibit the cell growth and metastasis of melanoma by negatively regulating MKK3. +genetics_overexpression_promote 31257534 hsa-mir-299 bladder urothelial carcinoma Inhibition of miR2993p promoted the invasive abilities of GC cells, whereas its overexpression significantly suppressed cell invasion. +genetics_overexpression_promote 31257534 hsa-mir-299 Stomach Neoplasms Inhibition of miR2993p promoted the invasive abilities of GC cells, whereas its overexpression significantly suppressed cell invasion. +other 31257526 hsa-mir-342 Pre-Eclampsia Our findings suggest that miR3423p may be a novel clinical indicator or prognostic marker for PE. +other 31257525 hsa-mir-26a Femoral Fractures In the present study, the role of miR26a5p and antimiR26a5pmodified ADSCs combined with biphasic calcium phosphate (BCP) scaffolds was evaluated in a rat femur defect model. ADSCs were infected with LvmiR26a5p, LvmiRNC, LvantimiR26a5p or LvantimiRNC respectively, and then combined with BCP scaffolds to repair rat femoral defects. +transcription factor target 31257524 hsa-mir-92a Esophageal Squamous Cell Carcinoma A miR92a3p mimic was found to promote ESCC cell proliferation and a miR92a3p inhibitor was found to reduce ESCC cell proliferation. +genetics_knock down_promote 31257522 hsa-mir-425 Carcinoma, Hepatocellular Furthermore, rescue experiments revealed that overexpression of FOXD3 counteracted the positive effects of miR4255p on HCC malignant behaviors. +genetics_overexpression_promote 31257521 hsa-mir-584 Carcinoma, Hepatocellular Notably, restored BDNF expression antagonized the inhibitory effects of miR584 overexpression on HCC cells. +transcription factor target 31257519 hsa-mir-33a Triple Negative Breast Neoplasms Luciferase reporter assay demonstrated that miR33a5p was bound to the 3'untranslated region of lactate dehydrogenase A (LDHA) and decreased the expression of LDHA in TNBC cells. Collectively, the results of the present study demonstrated that chidamide reprogramed glucose metabolism, partially by targeting the miR33a5p/LDHA pathway, in TNBC. +transcription factor target 31257513 hsa-mir-145 Down Syndrome miR30c, miR145, miR183 and their targets may serve important roles in the pathogenesis and development of complications in Down syndrome. +transcription factor target 31257513 hsa-mir-183 Down Syndrome miR30c, miR145, miR183 and their targets may serve important roles in the pathogenesis and development of complications in Down syndrome. +genetics_overexpression_promote 31257511 hsa-mir-20a Carcinoma, Hepatocellular The results indicated that overexpression of miR20a could suppress the replicative activity of HBV and increased the degree of methylation of HBV cccDNA in the HepAD38 hepatoma cell line. In conclusion, miR20a may be loaded onto AGO2, prior to its translocation into the nucleus, inducing the methylation of HBV DNA in human hepatoma cells, leading to the suppression of HBV replication. +other 31257508 hsa-mir-29 Lymphoma, Mantle-Cell It was previously reported that miR29 was involved in regulating proliferation, differentiation and survival in hepatocellular carcinoma, and osteoblast and mantle cell lymphoma; however, the effects of miR29 on NSPCs remain unclear. +other 31257508 hsa-mir-29 Carcinoma, Hepatocellular It was previously reported that miR29 was involved in regulating proliferation, differentiation and survival in hepatocellular carcinoma, and osteoblast and mantle cell lymphoma; however, the effects of miR29 on NSPCs remain unclear. +transcription factor target 31257504 hsa-mir-153 Neurodegenerative Diseases Therefore, miR153 may be a potential target for the treatment of certain neurodegenerative diseases. +genetics_knock down_promote 31257499 hsa-mir-4288 Urinary Bladder Neoplasms Furthermore, by performing a rescue assay, it was identified that inhibition of miR4288 was able to reverse the effects of LINC00978 knockdown on proliferation, migration and invasion of BCa cells. +genetics_overexpression_promote 31257489 hsa-mir-18a Squamous Cell Carcinoma of Head and Neck In vitro studies revealed that the cell viability, migration and invasion abilities of OSCC cells were promoted and cell apoptosis was inhibited by miR18a5p overexpression. +lncRNA target 31257477 hsa-mir-132 Diabetes Mellitus The findings of the present study suggested that increasing the expression of miR132 may serve as a novel therapeutic approach to inhibit the progression of cardiovascular disease in diabetes. +lncRNA target 31257477 hsa-mir-132 Cardiovascular Diseases The findings of the present study suggested that increasing the expression of miR132 may serve as a novel therapeutic approach to inhibit the progression of cardiovascular disease in diabetes. +other 31257474 hsa-mir-378 Acute Kidney Injury miRNAmRNA regulatory network analysis of mesenchymal stem cell treatment in cisplatininduced acute kidney injury identifies roles for miR210/Serpine1 and miR378/Fos in regulating inflammation. In conclusion, it can be speculated that gliclazide may have a similar mechanism to MSC as a potential therapeutic agent for cisplatininduced AKI, by regulating miR210/Serpine1 and miR378/Fosmediated inflammation and cell apoptosis. +other 31257474 hsa-mir-210 Acute Kidney Injury miRNAmRNA regulatory network analysis of mesenchymal stem cell treatment in cisplatininduced acute kidney injury identifies roles for miR210/Serpine1 and miR378/Fos in regulating inflammation. In conclusion, it can be speculated that gliclazide may have a similar mechanism to MSC as a potential therapeutic agent for cisplatininduced AKI, by regulating miR210/Serpine1 and miR378/Fosmediated inflammation and cell apoptosis. +genetics_overexpression_promote 31257462 hsa-mir-873 Thyroid Neoplasms Furthermore, ZEB1 restoration partially reversed the suppressive effects of miR873 overexpression on TC cell proliferation and invasion. +other 31257410 hsa-mir-363 Thyroid Cancer, Papillary 3p for the prevention of PTC metastasis. +genetics_overexpression_promote 31257090 hsa-mir-95 Osteosarcoma 3p overexpression inhibited the osteosarcoma growth and downregulated the HDGF expression in xenografted tumor. +genetics_overexpression_promote 31257059 hsa-mir-22 Squamous Cell Carcinoma of Head and Neck The results of Cell Counting Kit-8 (CCK-8) and flow cytometry analyses showed that quercetin treatment and miR-22 overexpression resulted in the reduction of cell viability and the increase of cell apoptotic rate in OSCC. +genetics_GWAS 31256999 hsa-mir-125b Endometriosis Rs354476 polymorphism affects the regulation of NUP210 gene expression by altering the binding with hsa-miR-125b-5p, a microRNA already known as playing an important role for endometriosis. +transcription factor target 31256424 hsa-mir-141 Fatty Liver Thus, miR-141/SIRT1/AMPK signaling pathway may be considered a potential target for the therapeutic management of NAFLD. +lncRNA target 31255724 hsa-mir-27a Urinary Bladder Neoplasms "Furthermore, we revealed that miR-27a-3p functioned as an oncogene through interacting with 5'UTR of cyclin D1 to enhance its expression, which led to promote cell cycle progression and proliferation in bladder cancer cells. Conclusively, our findings further confirm the hypothesis that circRNAs function as ""microRNA sponges"", and our data suggest that circNR3C1 and miR-27a-3p would be potential therapeutic targets for bladder cancer treatment." +lncRNA target 31255531 hsa-mir-412 Colonic Neoplasms 3p-targeted MYL9. +genetics_overexpression_promote 31255331 hsa-mir-199a Stomach Neoplasms The role of miR-199a-3p in the migration and invasion of gastric cancer cells was determined in overexpression and inhibitor studies using transwell assays and the SGC-7901, BGC-823 and MGC-803 gastric cancer cells lines. +other 31255253 hsa-mir-20a Breast Neoplasms AUC value equal to 0.949 in the ROC-analysis allows us to recommend the miRNA-20a as a marker of triple negative breast cancer to differentiate it from the luminal subtypes. +lncRNA target 31254605 hsa-mir-20b Breast Neoplasms By studying the regulatory mechanism, we found that miR20b biogenesis in BC cells can be attenuated by ASC-released stem cell factor (SCF) through the downstream c-Kit/MAPK-p38/E2F1 signaling cascade and that miR-20b acts as a tumor suppressor miRNA in the inhibition of BC migration and invasion. +genetics_GWAS 31254352 hsa-mir-96 Leukemia, Myeloid, Acute Following a comparative miRNA profiling analysis in genetically and enzymatically HDAC2-downregulated AML cells, we identified miR5p and miR-92a-3p as potential regulators in AML etiopathology by targeting defined genes. +genetics_GWAS 31254352 hsa-mir-92a Leukemia, Myeloid, Acute Following a comparative miRNA profiling analysis in genetically and enzymatically HDAC2-downregulated AML cells, we identified miR5p and miR-92a-3p as potential regulators in AML etiopathology by targeting defined genes. +other 31253987 hsa-mir-145 Carcinoma, Non-Small-Cell Lung 5p/CCND2 in the development and progression of NSCLC, which bring us closer to an understanding of the molecular drivers of NSCLC. +genetics_knock down_promote 31253842 hsa-mir-204 Osteoarthritis Specific knockout of miR-204/-211 in mesenchymal progenitor cells (MPCs) results in Runx2 accumulation in multi-type joint cells, causing whole-joint degeneration. +genetics_knock down_promote 31253842 hsa-mir-211 Osteoarthritis Specific knockout of miR-204/-211 in mesenchymal progenitor cells (MPCs) results in Runx2 accumulation in multi-type joint cells, causing whole-joint degeneration. +circulation_biomarker_prognosis_ns 31253822 hsa-mir-223 Neurodegenerative Diseases miR3p serum concentration discriminates between AD/MCI and PD, suggesting that this molecule could be a potential non-invasive biomarker for differential diagnosis and prognosis of these neurodegenerative conditions. +genetics_GWAS 31253192 hsa-mir-486 Mouth Neoplasms Aberrant methylation of ANK1 promoter was a highly prevalent in OSCC and contributes to oral carcinogenesis by epigenetic silencing of ANK1 and miR +genetics_knock down_promote 31253120 hsa-mir-23b Breast Neoplasms RESULTS: Characterization of the knockout cells in vitro demonstrated that miR-23b and miR-27b are indeed oncogenic miRNAs in MCF7 breast cancer cells. +genetics_knock down_promote 31253120 hsa-mir-27b Breast Neoplasms RESULTS: Characterization of the knockout cells in vitro demonstrated that miR-23b and miR-27b are indeed oncogenic miRNAs in MCF7 breast cancer cells. +lncRNA target 31253066 hsa-mir-3912 Cataract The results provide 2 molecular targets (e.g., NEIL2 and hsa-miR5p) for intervention strategies of ARC in the future.-Kang, L., Zou, X., Zhang, G., Xiang, J., Wang, Y., Yang, M., Chen, X., Wu, J., Guan, H. +lncRNA target 31253047 hsa-mir-93 Osteoarthritis METHODS: In the current study, chondrocytes were induced by interleukin-1beta (IL-1beta) to simulate OA condition, and further assessed cell viability, lncRNA MEG3 and miR-93 expression levels. CONCLUSION: LncRNA MEG3 targeted miR-93/TGFBR2 axis, regulated the proliferation, apoptosis and ECM degradation of chondrocytes in OA. +circulation_biomarker_diagnosis_ns 31252698 hsa-mir-375 Migraine Disorders Altogether, these findings suggested thathsa-miR-34a-5p and hsa-miR-375 are expressed equally in blood and saliva and that they could be a useful biomarker of disease and of drug efficacy in patients with MWA. +circulation_biomarker_diagnosis_ns 31252698 hsa-mir-34a Migraine Disorders Altogether, these findings suggested thathsa-miR-34a-5p and hsa-miR-375 are expressed equally in blood and saliva and that they could be a useful biomarker of disease and of drug efficacy in patients with MWA. +other 31252530 hsa-let-7e Depressive Disorder, Major Multiple linear regression analyses found that let-7e and miR-146a expression before treatment was inversely correlated with severity of depression, whereas miR-155 before treatment was directly correlated with severity of depression. +other 31252530 hsa-mir-155 Depression Levels of miR-146a and miR-155 in monocytes were lower in MDD patients than in controls and were increased in the former after antidepressant treatment. +other 31252530 hsa-mir-146a Depression Levels of miR-146a and miR-155 in monocytes were lower in MDD patients than in controls and were increased in the former after antidepressant treatment. +other 31252530 hsa-mir-146a Depressive Disorder, Major Levels of miR-146a and miR-155 in monocytes were lower in MDD patients than in controls and were increased in the former after antidepressant treatment. +other 31252530 hsa-let-7e Depression Multiple linear regression analyses found that let-7e and miR-146a expression before treatment was inversely correlated with severity of depression, whereas miR-155 before treatment was directly correlated with severity of depression. +other 31252530 hsa-mir-155 Depressive Disorder, Major Levels of miR-146a and miR-155 in monocytes were lower in MDD patients than in controls and were increased in the former after antidepressant treatment. +lncRNA target 31252267 hsa-mir-34a Carcinoma, Non-Small-Cell Lung SNHG14 silencing exerted its regulatory effect by miR-34a and HMGB1 mediated the regulatory effect of miR-34a on NSCLC cells. In conclusion, SNHG14 silencing suppressed NSCLC progression at least partly by miR-34a/HMGB1 axis in vitroand promoted NSCLC cell sensitivity to CDDP, highlighting that SNHG14 might be a potential target for NSCLC therapy. +lncRNA target 31252264 hsa-mir-127 Uterine Cervical Neoplasms In conclusion, our data verifies that lncRNA POU3 F3, induced by transcription factor SP1, acts as an oncogene in the cervical cancer tumorigenesis via regulating miR5p/FOXD1 axis, providing a possible therapeutic target for cervical cancer. +other 31251997 hsa-mir-483 Carcinoma, Hepatocellular SIGNIFICANCE: Overall, our study established a novel regulatory network of LncRNA MEG3/miR483-3p/ERp29 in HCC which may be helpful in better understanding the effect of high glucose on poor prognosis of HCC and in exploring new diagnostic and therapeutic tools for managing HCC in patients with diabetes. +lncRNA target 31251902 hsa-mir-495 Inflammatory Bowel Diseases OBJECTIVE: This article aims to investigate the mechanism of microRNA-495 (miR-495) and long non-coding RNA CRNDE on the apoptosis of colonic epithelial cells in inflammatory bowel diseases (IBDs). CONCLUSIONS: Our findings demonstrated that CRNDE promoted DSS-induced colonic epithelial cell apoptosis via suppressing miR-495 and increasing SOCS1, indicating CRNDE as a novel target of treating IBD. +genetics_overexpression_promote 31251735 hsa-mir-181c Osteosarcoma Moreover, miR-181c overexpression prominently repressed osteosarcoma cell proliferation, invasion, and migration abilities via modulating EMT and TGF-ss signaling pathway. +genetics_overexpression_promote 31251699 hsa-mir-718 Carcinoma, Hepatocellular SEMA3B-AS1 and PTEN overexpression resulted in a reduced proliferation rate of HCC cells, while miR-718 overexpression resulted in an increased rate. +transcription factor target 31251698 hsa-mir-29b Diabetes Mellitus We also showed that hepatic miR-29b exhibits persistent dysregulation during disease progression in a rat model of diabetes, UCD-T2DM. +lncRNA target 31251698 hsa-mir-29 Metabolic Diseases Future studies should investigate the therapeutic utility of miR-29 suppression in different metabolic disease states.Enho; insulin resistance; liver; microRNA-29 (miR-29); UCD-T2DM. +transcription factor target 31251698 hsa-mir-29 Diabetes Mellitus We also showed that hepatic miR-29b exhibits persistent dysregulation during disease progression in a rat model of diabetes, UCD-T2DM. +genetics_knock down_promote 31250987 hsa-mir-155 Carcinoma, Ovarian Epithelial 5p was confirmed to be the competing target of NORAD in EOC, and its knockdown in OVCAR-3 and ES-2 cells reversed the NORAD downregulation-induced anticancer functions. +other 31250578 hsa-mir-107 Alzheimer Disease CONCLUSION: LncRNA NEAT1 aggravated Abeta-induced neuronal damage by sponging miR-107, indicating a novel avenue for treatment of AD. +genetics_overexpression_promote 31250570 hsa-mir-33a Carcinoma, Renal Cell Furthermore, miR-33a overexpression significantly inhibited RCC cells growth than the control group, while the inhibitory effects of miR-33a were reversed upon the overexpression of MDM4. +other 31250518 hsa-mir-203 Carcinoma, Renal Cell In contrast, the expression of miRNA-203 in RCC tissues and cell lines was higher than that in adjacent normal tissues and a normal renal cortex proximal tubule epithelial cell line. CONCLUSIONS: Our study demonstrated that MALAT1 functions as a miR-203 decoy to increase BIRC5 expression in RCC. +circulation_biomarker_diagnosis_up 31249805 hsa-mir-199a Neuroblastoma By examining different exosomal miRNA expression profiles in the plasma of NB patients, we identified that the expression of hsa-miR199a-3p from exosomes was significantly upregulated, which was correlated with the severity of NB patients. +transcription factor target 31249647 hsa-mir-3 Vitamin B Deficiency 3p inhibitor and VER-155008 (GRP78 inhibitor) partly hindered the apoptosis caused by Se deficiency. +other 31249597 hsa-mir-15a Diabetic Nephropathies Bioinformatics analyses indicated that miR-30e-5p and miR-15a-5p regulate various genes that participate in pathways related to angiogenesis, apoptosis, cell differentiation, oxidative stress, and hypoxia. +circulation_biomarker_diagnosis_up 31249556 hsa-mir-518d Diabetic Angiopathies Conclusions: In this cohort of type 1 diabetes individuals, serum miR-518d-3p and miR-618 were upregulated in those with diabetes kidney disease, diabetes retinopathy, peripheral neuropathy, and cardiovascular autonomic neuropathy in comparison to individuals with no microvascular complications. +circulation_biomarker_diagnosis_up 31249556 hsa-mir-618 Diabetic Angiopathies Conclusions: In this cohort of type 1 diabetes individuals, serum miR-518d-3p and miR-618 were upregulated in those with diabetes kidney disease, diabetes retinopathy, peripheral neuropathy, and cardiovascular autonomic neuropathy in comparison to individuals with no microvascular complications. +transcription factor target 31249522 hsa-mir-34a Macular Degeneration Accordingly, miR-34a may play a key role in age-related susceptibility to oxidative stress in ARPE-19 cells by targeting the SIRT1/p66shc pathway, leading to AMD. In this review article, we discuss the functions of miR-34a in modulating the SIRT1/p66shc pathway in age-related conditions, including AMD. +genetics_knock down_promote 31249473 hsa-mir-503 Stomach Neoplasms Subsequently, in vitro, gain-function and loss-function assays confirmed that miR-503 overexpression significantly suppressed GC cell proliferation, colony formation and cell invasion, while decreased miR-503 expression had an adverse effect in GC cells. +circulation_biomarker_diagnosis_down 31248594 hsa-mir-19a Osteoporosis Serum levels of miRNA-19a-3p, RUNX2 and OCN in osteoporosis patients and controls were determined by quantitative real-time polymerase chain reaction (qRT-PCR). +genetics_knock down_promote 31248450 hsa-mir-335 Tuberculosis Gain and loss of function of miR +lncRNA target 31248373 hsa-mir-335 Breast Neoplasms Interestingly, ectopic expression of miR-335 suppressed CDH11, beta-catenin and vimentin expression, in concert with attenuated metastatic and CSC potentials of the MBC cells; conversely, inhibition of miR-335 resulted in increased metastatic potential. +genetics_overexpression_promote 31248310 hsa-mir-34a Triple Negative Breast Neoplasms PAPAS overexpression promoted in vitro migration and invasion of TNBC cells, while miR-34a overexpression was inhibitory. +genetics_overexpression_promote 31247272 hsa-mir-182 Uterine Cervical Neoplasms Furthermore, the Smad4 signaling pathway was activated upon TGF-beta overexpression, which led to an interaction between Smad4 and the miR-182 promoter region, subsequently inducing the upregulation of miR-182 in both cervical cancer cells and the surrounding normal cells. +lncRNA target 31247211 hsa-mir-136 Esophageal Squamous Cell Carcinoma Up-regulation of miR-136 reduced the survival rate, suppressed colony formation ability and induced apoptosis of ESCC cells under irradiation, which was reversed by upregulated MUC1. +transcription factor target 31247197 hsa-mir-34a Congenital central hypoventilation syndrome These results demonstrate that ethanol-induced inhibition of neural differentiation of NCCs is mediated by the miR-34a through targeting Atg9a. +genetics_overexpression_suppress 31247032 hsa-mir-19a spondyloepimetaphyseal dysplasia, Strudwick type Functional studies indicated that overexpression of miR-19a enhanced the proliferation and migration of ASM cells, whereas inhibition of miR-19a decreased the proliferation and migration of ASM cells. +other 31247032 hsa-mir-19 Primary Myelofibrosis MiR-19 only regulates the proliferation of HASM cells induced by HMGB1, but not PDGF, EGF, TGF-beta1. +genetics_overexpression_suppress 31247032 hsa-mir-19 spondyloepimetaphyseal dysplasia, Strudwick type Functional studies indicated that overexpression of miR-19a enhanced the proliferation and migration of ASM cells, whereas inhibition of miR-19a decreased the proliferation and migration of ASM cells. +other 31246497 hsa-mir-101 Arthritis, Rheumatoid We suggested that miR-101 that regulated DUSP1, IRF1 TF that regulated CXCR4, as well as DEGs as TYROBP and CTSS might contribute to the RA pathogenesis. +other 31246422 hsa-mir-200c Breast Neoplasms Finally, quantification of miR-200c in breast cancer stem cells (BCSCs) and in stem cells isolated from breast tumors was performed. +genetics_knock down_promote 31246330 hsa-mir-432 Glioma CONCLUSIONS: Knockdown of ZFAS1 inhibited the viability and enhanced cisplatin sensitivity via targeting miR +genetics_overexpression_promote 31246264 hsa-mir-1204 Carcinoma, Non-Small-Cell Lung The overexpression of miR-1204 increases the apoptosis rate in NSCLC cells. +genetics_overexpression_suppress 31245927 hsa-mir-7 Breast Neoplasms Overexpression of miR-7 could reverse the enhanced sensitivity of silenced CDR1as to drug-resistant breast cancer cells. +lncRNA target 31245894 hsa-mir-146a Arthritis, Rheumatoid CONCLUSION: miRNA expression profile is closely implicated in the treatment efficacy of TNF inhibitor, and combined measurement of miR-146a-5p, let-7a-5p, CRP, and biologics history disclosed a great predictive value for clinical response to TNF inhibitor in RA patients. +lncRNA target 31245894 hsa-let-7a Arthritis, Rheumatoid CONCLUSION: miRNA expression profile is closely implicated in the treatment efficacy of TNF inhibitor, and combined measurement of miR-146a-5p, let-7a-5p, CRP, and biologics history disclosed a great predictive value for clinical response to TNF inhibitor in RA patients. +transcription factor target 31245877 hsa-mir-206 Thyroid Neoplasms Our study showed that miR-206 negatively regulated cell activities of proliferation, invasion, and migration in TC via suppressing RAP1B expression, suggesting that miR-206 exerts a vital role in TC. +transcription factor target 31245291 hsa-mir-126 Granulosa Cell Tumor We examined the role of miR-126 in granulosa cell tumor (GCT) of the ovaries. We showed that miR-126 could inhibit proliferation, migration, hormone production and promote apoptosis of cancerous granulosa cells (GCs) in vitro. +exosome 31244932 hsa-mir-124 Reperfusion Injury Conclusions: We demonstrated that M2 microglia-derived exosomes attenuated ischemic brain injury and promoted neuronal survival via exosomal miR-124 and its downstream target USP14. +circulation_biomarker_diagnosis_up 31244320 hsa-mir-17 Carcinoma, Non-Small-Cell Lung This study aimed to assess the plasma level of circulating miRNA-17 and miRNA-222 as non-invasive markers in non-small-cell lung cancer (NSCLC) patients. +circulation_biomarker_diagnosis_up 31244320 hsa-mir-222 Carcinoma, Non-Small-Cell Lung This study aimed to assess the plasma level of circulating miRNA-17 and miRNA-222 as non-invasive markers in non-small-cell lung cancer (NSCLC) patients. +other 31244315 hsa-mir-335 Gallbladder Neoplasms Conclusions: Down regulation of miR-335 is associated with the severity of the disease and thus indicate that miR-335 expression may serve as prognostic marker for GBC. +other 31244281 hsa-mir-200c Carcinoma, Non-Small-Cell Lung In this study, expression levels of miR-200c and miR-9, ZEB-1, ZEB-2 and E-cadherin were assessed in 30 non-small cell lung cancers (NSCLCs) by real-time qPCR. +other 31244281 hsa-mir-9 Carcinoma, Non-Small-Cell Lung In this study, expression levels of miR-200c and miR-9, ZEB-1, ZEB-2 and E-cadherin were assessed in 30 non-small cell lung cancers (NSCLCs) by real-time qPCR. These results indicate roles for miR-9 and ZEB1 in genesis of lung cancer, although clinico-pathological associations were not evident. +lncRNA target 31243990 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck gingivalis DNA levels were positively correlated with miR-21 and c-Jun expression and negatively correlated with PDCD4 expression in clinical OSCC samples. gingivalis might promote OSCC proliferation by regulating cyclin D1 expression via the miR-21/PDCD4/AP-1 negative feedback signaling pathway. +lncRNA target 31243884 hsa-mir-203 Carcinoma, Non-Small-Cell Lung Our results revealed that expression levels of circAGFG1 and miR-203 are upregulated in non-small-cell lung cancer tissues. In conclusion, our study suggests that circAGFG1 promotes NSCLC growth and metastasis though a circAGFG1/miR-203/ZNF281 axis and may represent a novel therapeutic target. +lncRNA target 31243821 hsa-mir-149 Carcinoma, Non-Small-Cell Lung 5p/Cdk6 axis in NSCLC progression and provided novel evidence that HNF1A-AS1 may be a new potential therapeutic target for the treatment of NSCLC. +lncRNA target 31243806 hsa-mir-488 Esophageal Squamous Cell Carcinoma 3p had alternate targets in ESCC by confirming the involvement of protein kinase, DNA-activated, catalytic subunit (PRKDC), a known target for miR +genetics_overexpression_promote 31243804 hsa-mir-579 Glioblastoma Our results represented that overexpression of miR-579 could inhibit proliferation, migration, cell cycle and also promoted the apoptosis of GBM cell lines. +transcription factor target 31243669 hsa-mir-29c Corneal dystrophy, epithelial basement membrane These indicate that SAN may inhibit the proliferation of BGC-823 cells through the inhibition of miR +transcription factor target 31243669 hsa-mir-96 Corneal dystrophy, epithelial basement membrane These indicate that SAN may inhibit the proliferation of BGC-823 cells through the inhibition of miR +lncRNA target 31243650 hsa-mir-206 Seizures Taken together, our results showed that expression of miR-206 could inhibit seizure-induced brain injury by targeting CCL2. Our results showed that expression of miR-206 could inhibit seizure-induced brain injury by targeting CCL2. +genetics_overexpression_promote 31243644 hsa-mir-138 Breast Neoplasms 5p could down-regulate the expression of RHBDD1, but overexpression of RHBDD1 reversed the suppressive effects of miR +transcription factor target 31243572 hsa-mir-144 Thalassemia Taken together, our findings suggest that dysregulation of miR-144 may play a role in the reduced ability of erythrocyte to deal with oxidative stress and increased RBC hemolysis susceptibility especially in thalassemia. +genetics_overexpression_promote 31243168 hsa-mir-146a Osteoarthritis CONCLUSION: miR-146a-5p was significantly overexpressed in patients with OA, both in the articular cartilage tissue and serum, with a positive correlation between the levels in both types of samples. +lncRNA target 31243136 hsa-mir-455 Rabies Furthermore, the downregulated STAT3 inhibits the production of IL-6, thereby contributing to a reduction in the inflammatory response in vivo Our study indicates that PGG effectively inhibits the replication of RABV by the miR +other 31242815 hsa-mir-33a Atherosclerosis Conclusions The miR-33 family exhibits differences in distribution and regulation and particularly in the progression of atherosclerosis; miR-33b would be more potent than miR-33a. +other 31242815 hsa-mir-3 Atherosclerosis Conclusions The miR-33 family exhibits differences in distribution and regulation and particularly in the progression of atherosclerosis; miR-33b would be more potent than miR-33a. +lncRNA target 31242722 hsa-mir-507 Colorectal Neoplasms CONCLUSIONS: LINC00525 enhanced stemness properties and increased sensitivities of CRC cells to oxaliplatin by targeting miR-507/ELK3 axis. +circulation_biomarker_diagnosis_ns 31242452 hsa-mir-29c Human T-Cell Leukemia Virus Type 1 Infections Our findings highlight serum miR-29c, miR-30c, miR-193a-5p and miR +circulation_biomarker_diagnosis_ns 31242452 hsa-mir-193a Human T-Cell Leukemia Virus Type 1 Infections Our findings highlight serum miR-29c, miR-30c, miR-193a-5p and miR +circulation_biomarker_diagnosis_ns 31242452 hsa-mir-885 Human T-Cell Leukemia Virus Type 1 Infections Our findings highlight serum miR-29c, miR-30c, miR-193a-5p and miR +genetics_overexpression_promote 31242182 hsa-mir-34 Prostatic Hyperplasia Overexpressing miR-34 in LW BPHs by injecting agomir-34 induces the development towards SW BPHs, whereas knocking down miR-34 in SW BPHs by injecting antagomir-34 induces more LW BPHs when another NlInR1 suppressor, NlInR2, is also suppressed simultaneously. +other 31242182 hsa-mir-34 Pigmentation Disorders Here, we discovered that a conserved microRNA, miR-34, modulates a positive autoregulatory feedback loop of JH and insulin/IGF signaling (IIS) pathway to control wing polyphenism in BPH. A cis-response element of Broad Complex (Br-C) is found in the promoter region of Nlu-miR-34, suggesting that 20-hydroxyecdysone (20E) might be involved in wing polyphenism regulation. +circulation_biomarker_diagnosis_up 31242129 hsa-mir-145 Multiple Myeloma phosphate dehydrogenase; GFP: green fluorescent protein; HDAC4: histone deacetylase 4; ISS: International Staging System; MAP1LC3B: microtubule associated protein 1 light chain 3 beta; miRNAs: microRNAs; MIR145-3p: microRNA 145-3p; MM: multiple myeloma; mRNA: messenger RNA; MTOR: mechanistic target of rapamycin kinase; MTORC1: mechanistic target of rapamycin kinase complex 1; PCs: plasma cells; PFS: progression-free survival; qRT-PCR: quantitative reverse transcription PCR; RPS6KB1: ribosomal protein S6 kinase B1; SD: standard deviation; siRNA: small interfering RNA; SQSTM1: sequestosome 1; STV: starvation; TUBB: tubulin beta class I. +lncRNA target 31241800 hsa-mir-211 Carcinoma, Non-Small-Cell Lung Recue experiments showed DGCR5 regulates NSCLC cell behaviors via targeting miR +lncRNA target 31241772 hsa-mir-30 Colorectal Neoplasms We conclude that miR-330 acts as a tumor suppressor miRNA in CRC by suppressing HMGA2 expression and reducing cell survival, proliferation, and migration. +genetics_knock down_promote 31241217 hsa-mir-600 Carcinoma, Non-Small-Cell Lung The circPIP5K1A knockdown suppressed NSCLC cell metastasis and proliferation by promoting expression of miR-600. +other 31241205 hsa-mir-525 Carcinoma, Non-Small-Cell Lung We found that high expression of 7 miRNAs (miR-301b, miR-383, miR-512, miR-515, miR-525, miR-577, and miR-5682) and low expression of five miRNAs (miR-448, miR-486, miR-4732,miR-4732, miR-516, and miR-1911) can significantly improve the overall survival rate of patients with LUSC. +other 31241205 hsa-mir-4732 Carcinoma, Non-Small-Cell Lung We found that high expression of 7 miRNAs (miR-301b, miR-383, miR-512, miR-515, miR-525, miR-577, and miR-5682) and low expression of five miRNAs (miR-448, miR-486, miR-4732,miR-4732, miR-516, and miR-1911) can significantly improve the overall survival rate of patients with LUSC. +other 31241205 hsa-mir-448 Carcinoma, Non-Small-Cell Lung We found that high expression of 7 miRNAs (miR-301b, miR-383, miR-512, miR-515, miR-525, miR-577, and miR-5682) and low expression of five miRNAs (miR-448, miR-486, miR-4732,miR-4732, miR-516, and miR-1911) can significantly improve the overall survival rate of patients with LUSC. +other 31241205 hsa-mir-1911 Carcinoma, Non-Small-Cell Lung We found that high expression of 7 miRNAs (miR-301b, miR-383, miR-512, miR-515, miR-525, miR-577, and miR-5682) and low expression of five miRNAs (miR-448, miR-486, miR-4732,miR-4732, miR-516, and miR-1911) can significantly improve the overall survival rate of patients with LUSC. +other 31241205 hsa-mir-512 Carcinoma, Non-Small-Cell Lung We found that high expression of 7 miRNAs (miR-301b, miR-383, miR-512, miR-515, miR-525, miR-577, and miR-5682) and low expression of five miRNAs (miR-448, miR-486, miR-4732,miR-4732, miR-516, and miR-1911) can significantly improve the overall survival rate of patients with LUSC. +other 31241205 hsa-mir-516 Carcinoma, Non-Small-Cell Lung We found that high expression of 7 miRNAs (miR-301b, miR-383, miR-512, miR-515, miR-525, miR-577, and miR-5682) and low expression of five miRNAs (miR-448, miR-486, miR-4732,miR-4732, miR-516, and miR-1911) can significantly improve the overall survival rate of patients with LUSC. +other 31241205 hsa-mir-383 Carcinoma, Non-Small-Cell Lung We found that high expression of 7 miRNAs (miR-301b, miR-383, miR-512, miR-515, miR-525, miR-577, and miR-5682) and low expression of five miRNAs (miR-448, miR-486, miR-4732,miR-4732, miR-516, and miR-1911) can significantly improve the overall survival rate of patients with LUSC. +other 31241205 hsa-mir-515 Carcinoma, Non-Small-Cell Lung We found that high expression of 7 miRNAs (miR-301b, miR-383, miR-512, miR-515, miR-525, miR-577, and miR-5682) and low expression of five miRNAs (miR-448, miR-486, miR-4732,miR-4732, miR-516, and miR-1911) can significantly improve the overall survival rate of patients with LUSC. +other 31241205 hsa-mir-5682 Carcinoma, Non-Small-Cell Lung We found that high expression of 7 miRNAs (miR-301b, miR-383, miR-512, miR-515, miR-525, miR-577, and miR-5682) and low expression of five miRNAs (miR-448, miR-486, miR-4732,miR-4732, miR-516, and miR-1911) can significantly improve the overall survival rate of patients with LUSC. +other 31241205 hsa-mir-486 Carcinoma, Non-Small-Cell Lung We found that high expression of 7 miRNAs (miR-301b, miR-383, miR-512, miR-515, miR-525, miR-577, and miR-5682) and low expression of five miRNAs (miR-448, miR-486, miR-4732,miR-4732, miR-516, and miR-1911) can significantly improve the overall survival rate of patients with LUSC. +other 31240987 hsa-mir-223 Thrombocythemia, Essential We showed that miR-9 and miR-490 were significantly upregulated in ET patients compared with healthy controls (p-values < 0.01), while miR-10a, miR-28, miR-126, miR-155, miR-221, miR-222, miR-223 and miR-431 were significantly downregulated in ET patients (all p-values < 0.001). +other 31240987 hsa-mir-221 Thrombocythemia, Essential We showed that miR-9 and miR-490 were significantly upregulated in ET patients compared with healthy controls (p-values < 0.01), while miR-10a, miR-28, miR-126, miR-155, miR-221, miR-222, miR-223 and miR-431 were significantly downregulated in ET patients (all p-values < 0.001). +other 31240987 hsa-mir-28 Thrombocythemia, Essential We showed that miR-9 and miR-490 were significantly upregulated in ET patients compared with healthy controls (p-values < 0.01), while miR-10a, miR-28, miR-126, miR-155, miR-221, miR-222, miR-223 and miR-431 were significantly downregulated in ET patients (all p-values < 0.001). +other 31240987 hsa-mir-431 Thrombocythemia, Essential A significant positive correlation was observed between miR-431 and MPV, IPC and IPF (all p-values < 0.05). +other 31240987 hsa-mir-10a Thrombocythemia, Essential We showed that miR-9 and miR-490 were significantly upregulated in ET patients compared with healthy controls (p-values < 0.01), while miR-10a, miR-28, miR-126, miR-155, miR-221, miR-222, miR-223 and miR-431 were significantly downregulated in ET patients (all p-values < 0.001). +other 31240987 hsa-mir-222 Thrombocythemia, Essential We showed that miR-9 and miR-490 were significantly upregulated in ET patients compared with healthy controls (p-values < 0.01), while miR-10a, miR-28, miR-126, miR-155, miR-221, miR-222, miR-223 and miR-431 were significantly downregulated in ET patients (all p-values < 0.001). +other 31240987 hsa-mir-490 Thrombocythemia, Essential We showed that miR-9 and miR-490 were significantly upregulated in ET patients compared with healthy controls (p-values < 0.01), while miR-10a, miR-28, miR-126, miR-155, miR-221, miR-222, miR-223 and miR-431 were significantly downregulated in ET patients (all p-values < 0.001). +other 31240987 hsa-mir-155 Thrombocythemia, Essential We showed that miR-9 and miR-490 were significantly upregulated in ET patients compared with healthy controls (p-values < 0.01), while miR-10a, miR-28, miR-126, miR-155, miR-221, miR-222, miR-223 and miR-431 were significantly downregulated in ET patients (all p-values < 0.001). +other 31240987 hsa-mir-126 Thrombocythemia, Essential We showed that miR-9 and miR-490 were significantly upregulated in ET patients compared with healthy controls (p-values < 0.01), while miR-10a, miR-28, miR-126, miR-155, miR-221, miR-222, miR-223 and miR-431 were significantly downregulated in ET patients (all p-values < 0.001). +other 31240987 hsa-mir-9 Thrombocythemia, Essential We showed that miR-9 and miR-490 were significantly upregulated in ET patients compared with healthy controls (p-values < 0.01), while miR-10a, miR-28, miR-126, miR-155, miR-221, miR-222, miR-223 and miR-431 were significantly downregulated in ET patients (all p-values < 0.001). +lncRNA target 31240979 hsa-mir-200a Carcinoma, Non-Small-Cell Lung Besides, MALAT1 promoted proliferation, mobility, migration, and invasion of NSCLC cells via sponging miR-200a-3p. +other 31240955 hsa-mir-663 Colorectal Neoplasms In conclusion, miR-663 was up-regulated in CRC patients and may be an effective biomarker for CRC diagnosis. +circulation_biomarker_diagnosis_up 31240850 hsa-mir-629 Hypertension, Pulmonary Furthermore, the expression of miR-629 was up-regulated, and the expression of FOXO3 and PERP mRNA was down-regulated in the plasma from PAH patients when compared to healthy controls. +other 31240830 hsa-mir-208 Myocardial Infarction, Acute The selected miRNAs presented high accuracy in discriminating SCD from AMI (miR-1 and miR-499) and AMI from control (miR-208) representing a potential aid for both clinicians and pathologists for differential diagnosis. +other 31240830 hsa-mir-208 Ischemic Stroke The selected miRNAs presented high accuracy in discriminating SCD from AMI (miR-1 and miR-499) and AMI from control (miR-208) representing a potential aid for both clinicians and pathologists for differential diagnosis. +other 31240830 hsa-mir-499 Ischemic Stroke The selected miRNAs presented high accuracy in discriminating SCD from AMI (miR-1 and miR-499) and AMI from control (miR-208) representing a potential aid for both clinicians and pathologists for differential diagnosis. +other 31240830 hsa-mir-499 Myocardial Infarction, Acute The selected miRNAs presented high accuracy in discriminating SCD from AMI (miR-1 and miR-499) and AMI from control (miR-208) representing a potential aid for both clinicians and pathologists for differential diagnosis. +other 31240830 hsa-mir-1 Myocardial Infarction, Acute The selected miRNAs presented high accuracy in discriminating SCD from AMI (miR-1 and miR-499) and AMI from control (miR-208) representing a potential aid for both clinicians and pathologists for differential diagnosis. +other 31240830 hsa-mir-1 Ischemic Stroke The selected miRNAs presented high accuracy in discriminating SCD from AMI (miR-1 and miR-499) and AMI from control (miR-208) representing a potential aid for both clinicians and pathologists for differential diagnosis. +other 31240600 hsa-mir-16 Alzheimer Disease 3p, was consistently identified in LOAD patients. +other 31240600 hsa-mir-132 Alzheimer Disease 3p, was consistently identified in LOAD patients. +other 31240600 hsa-mir-107 Alzheimer Disease 3p, was consistently identified in LOAD patients. +other 31240600 hsa-mir-146a Alzheimer Disease 3p, was consistently identified in LOAD patients. +other 31240600 hsa-mir-125 Alzheimer Disease 3p, was consistently identified in LOAD patients. +other 31240600 hsa-mir-34a Alzheimer Disease 3p, was consistently identified in LOAD patients. +other 31240600 hsa-mir-181 Alzheimer Disease 3p, was consistently identified in LOAD patients. +other 31240600 hsa-mir-212 Alzheimer Disease 3p, was consistently identified in LOAD patients. +other 31240443 hsa-mir-140 Attention Deficit Disorder with Hyperactivity 3p on hyperactivity/impulsivity symptoms was mediated by left fusiform gyrus. +other 31240436 hsa-mir-6807 Stomach Neoplasms 5p significantly decreased to undetectable level after curative resection of GC. +other 31240436 hsa-mir-6856 Stomach Neoplasms 5p significantly decreased to undetectable level after curative resection of GC. +lncRNA target 31239781 hsa-mir-6716 Colorectal Neoplasms 5p inhibitor inhibited CRC cell migration and invasion. +other 31239767 hsa-mir-21 Leukemia, Lymphocytic, Chronic, B-Cell Methods: The expression of miR-21, miR-34a, miR-181a and miR-221 in previously separated leukemic cells was assessed with the use of qRQ-PCR technique at the moment of diagnosis in 40 CLL patients. +genetics_GWAS 31239767 hsa-mir-34a Leukemia, Lymphocytic, Chronic, B-Cell Conclusions: These results may prove an important role of miR-34a expression as a predictor of apoptosis, even in cases when other risk factors like cytogenetic abnormalities are absent. +other 31239767 hsa-mir-221 Leukemia, Lymphocytic, Chronic, B-Cell Methods: The expression of miR-21, miR-34a, miR-181a and miR-221 in previously separated leukemic cells was assessed with the use of qRQ-PCR technique at the moment of diagnosis in 40 CLL patients. +other 31239767 hsa-mir-181a Leukemia, Lymphocytic, Chronic, B-Cell Methods: The expression of miR-21, miR-34a, miR-181a and miR-221 in previously separated leukemic cells was assessed with the use of qRQ-PCR technique at the moment of diagnosis in 40 CLL patients. +other 31239716 hsa-mir-1182 Carcinoma, Hepatocellular Conclusion: Our results illustrated that the LINC00339/miR-1182/SKA1 axis plays an essential role in HCC progression. +lncRNA target 31239155 hsa-mir-140 Non-alcoholic Fatty Liver Disease CONCLUSION: The NEAT1-miR-140 axis play a crucial role in modulation of NAFLD via inactivation of AMPK/SREBP1 signaling. +genetics_GWAS 31239006 hsa-mir-137 Schizophrenia CONCLUSION: The findings suggested that these two functional connectivities of the DLPFC could be important endophenotypes linking the MIR137-regulated genetic structure to schizophrenia. +circulation_biomarker_diagnosis_up 31238581 hsa-mir-451 Myasthenia Gravis We previously reported that the up-regulation of gga-miR-451 negatively regulates the Mycoplasma gallisepticum (MG)-induced production of inflammatory cytokines via targeting tyrosine3-monooxygenase/tryptophan5-monooxygenase activation protein zeta (YWHAZ). +other 31238337 hsa-mir-23a Colorectal Neoplasms This study identified a novel mechanism involving YWHAE-encoded lncRNA, miR-323a-3p and miR5p in regulating HCT116 cell survival and suggested a potential therapeutic avenue for colorectal cancer. +other 31238337 hsa-mir-532 Colorectal Neoplasms This study identified a novel mechanism involving YWHAE-encoded lncRNA, miR-323a-3p and miR5p in regulating HCT116 cell survival and suggested a potential therapeutic avenue for colorectal cancer. +transcription factor target 31238191 hsa-mir-96 Multiple Sclerosis CONCLUSION: IL-10 and miR-96 are associated with MS quiescence, however, the lack of a significant correlation between them implicates that the influence of miR-96 may be exhibited through some pathway other than IL-10. +lncRNA target 31238052 hsa-mir-384 Laryngeal Neoplasms Collectively, our results indicate that SNHG3 regulated LC cell migration and invasion via the miR-384/WEE1 axis. +lncRNA target 31237865 hsa-mir-223 Hypoxia-Ischemia, Brain The level of miR-223 was increased, while the levels of NLRP3, caspase-1, IL-1ss, and IL-18 were decreased in the peri-infarct cortex of EA-treated MCAO rats. CONCLUSIONS These data suggest that EA treatment can alleviate neuroinflammation by inhibiting the miR-223/NLRP3 pathway, thus playing a neuroprotective role in MCAO in rats. +other 31237446 hsa-mir-455 Carcinoma, Hepatocellular In this study, we reveal a novel mechanism underlying MCM3AP-AS1-induced HCC metastasis by regulating miR-455. +transcription factor target 31237127 hsa-mir-34a Diabetic Cardiomyopathies CONCLUSION: Our results indicate that G-CSF might have an anti-apoptotic effect through down-regulation of miR-34a in a diabetic cardiomyopathy rat model. +other 31237044 hsa-mir-4638 Lymphoma, Large B-Cell, Diffuse In conclusion, our studies demonstrated aberrant ERG expression in a subset of DLBCL, which is associated with downregulation of miR5p. +lncRNA target 31237010 hsa-mir-30 Melanoma The results showed that increase in miR-330 expression level could significantly inhibit the tumor cell growth and the migration of melanoma cancer cells. +lncRNA target 31236854 hsa-mir-1246 Urinary Bladder Neoplasms MicroRNA-1246 regulates the radio-sensitizing effect of curcumin in bladder cancer cells via activating P53. CONCLUSION miR-1246 is involved in the anti-cancer effects of curcumin and irradiation through targeting the inhibition of p53 gene translation in bladder cancer cells. +circulation_biomarker_diagnosis_down 31236600 hsa-mir-148 Carcinoma, Non-Small-Cell Lung 5p expression and decreased blood level of miR-148a-3p was associated with higher stage of NSCLC. +circulation_biomarker_diagnosis_down 31236600 hsa-mir-148a Carcinoma, Non-Small-Cell Lung 5p expression and decreased blood level of miR-148a-3p was associated with higher stage of NSCLC. +other 31236545 hsa-mir-17 Histiocytic Sarcoma 92 network, that enhances Wnt pathway activity, could be responsible for the selection of malignant LGR6(+) tumour cells. +lncRNA target 31235746 hsa-mir-126 Breast Neoplasms Among the most affected ncRNAs, we found that sorafenib mediated the dysregulation of the lncRNAs GAS5, HOTTIP and HOXA-AS2 and the miR3p, in a panel of human cancer cell lines (HCC, renal and breast carcinomas). +circulation_biomarker_diagnosis_ns 31235746 hsa-mir-126 Carcinoma, Hepatocellular The levels of plasmatic circulating miR +lncRNA target 31235732 hsa-mir-211 Ovarian Neoplasms In this study, by assessing miRNAs simultaneously targeting a set of DDR genes that exhibited response to platinum, we found that miR-211 inhibited most of those genes, and proposed that miR-211 might affect the sensitivity of ovarian cancer cells to platinum by targeting multiple DDR genes and thereby determine the prognosis of ovarian cancer. +other 31235696 hsa-mir-217 Pituitary Neoplasms In summary, this study revealed that FOXP1-induced CLRN1-AS1 regulated cellular functions in pituitary prolactinoma by sponging miR-217 to release the DKK1/Wnt/beta-catenin signaling pathway. +genetics_GWAS 31235484 hsa-mir-146a Arthritis The heterozygous model showed a significant association between the miR-146a rs2910164 (G/C) polymorphism and ankylosing spondylitis (AS). And there was a significant association between miR-146a rs2910164(G/C) and PsA or AS. +genetics_GWAS 31235484 hsa-mir-149 Arthritis These findings did not support the genetic association between miR-146a rs2910164 (G/C) and JRA susceptibility, as well as the association of miR-196a-2 rs11614913 (C/T), miR-146a rs2431697, miR-146a rs57095329, miR-149 rs22928323 with arthritis. +other 31235259 hsa-mir-98 Osteoporosis, Postmenopausal AIM: We aimed to analyze circRNA expression profiles in osteoporosis and explore the molecular mechanism of circRNA_0016624 and interaction between circRNA_0016624, miR-98 and BMP2 during osteogenic differentiation. CONCLUSION: circRNA_0016624 could sponge miR-98 and enhance BMP2 expression, thus circRNA_0016624 prevents osteoporosis and may provide a novel therapeutic strategy. +lncRNA target 31235073 hsa-mir-23b Cataract The findings present the first evidence indicating that miR-23b can promote the proliferation, migration, and EMT of LECs by targeting SPRY2 and the inhibition of miR-23b may possess the therapeutic potential for cataract. +circulation_biomarker_prognosis_up 31234535 hsa-mir-125b Breast Neoplasms 3p were upregulated in BC plasma and able to discriminate BC patients from healthy subjects (miR +other 31234535 hsa-mir-125 Breast Neoplasms 5p in cancer-associated fibroblasts, and neither in epithelial tumour cells. +other 31234535 hsa-mir-143 Breast Neoplasms 5p in cancer-associated fibroblasts, and neither in epithelial tumour cells. +circulation_biomarker_diagnosis_ns 31234177 hsa-mir-1 Non-ST Elevated Myocardial Infarction CONCLUSION: Circulating microRNA-1 is capable of early diagnosis of NSTEMI in patients with CKD suffering from chest pain. +circulation_biomarker_diagnosis_ns 31234177 hsa-mir-1 Kidney Failure, Chronic CONCLUSION: Circulating microRNA-1 is capable of early diagnosis of NSTEMI in patients with CKD suffering from chest pain. +other 31233824 hsa-mir-143 Schizophrenia The antipsychotics haloperidol and clozapine attenuated hyperlocomotion and the decrease in miR-143 expression induced by PCP, as did the selective D2 dopamine receptor antagonist eticlopride but not the selective D1 antagonist SCH23390. +other 31233772 hsa-mir-126 Endometriosis 5p negatively regulated BCAR3 expression in eutopic endometriosis, enhanced the migration and invasion of endometrial cells, and promoted the occurrence of endometriosis. +other 31233760 hsa-mir-139 Carcinoma, Hepatocellular 5p might act as a promising prognostic indicator for HCC patients. +genetics_knock down_promote 31233752 hsa-mir-188 Colorectal Neoplasms 5p, and overexpression of USP47 attenuated LINC00668 knockdown-induced tumor suppressive effects in CRC cells. +other 31233201 hsa-let-7 Carcinoma, Non-Small-Cell Lung Therefore, this study demonstrated that let7 and miR17 were involved in the regulation of EGFRTKI resistance, and could be used as predictive biomarkers of EGFRTKI resistance in NSCLC. +other 31233201 hsa-mir-17 Carcinoma, Non-Small-Cell Lung Therefore, this study demonstrated that let7 and miR17 were involved in the regulation of EGFRTKI resistance, and could be used as predictive biomarkers of EGFRTKI resistance in NSCLC. +other 31233193 hsa-mir-142 Precursor Cell Lymphoblastic Leukemia-Lymphoma Importantly, expression levels of miR1423p and miR17~92 cluster were upregulated in the BCPALL cell line with acquired DEX resistance as examined by RTqPCR. Our results suggest that interference of miR1423p and miR17~92 may overcome the resistance of BCPALL to GCs. +other 31233193 hsa-mir-142 Epilepsy, Rolandic Importantly, expression levels of miR1423p and miR17~92 cluster were upregulated in the BCPALL cell line with acquired DEX resistance as examined by RTqPCR. Our results suggest that interference of miR1423p and miR17~92 may overcome the resistance of BCPALL to GCs. +other 31233191 hsa-mir-223 Urinary Bladder Neoplasms Finally, seven micro (mi) RNAs (miR2145p, miR2233p, miR1555p, miR199a3p, miR199b3P, miR146b5p, miR1425p) which were expressed differentially in at least three mutant genes and were positively correlated with M2 macrophage infiltration as well as expressed highly in high grade bladder cancer were identified. +other 31233191 hsa-mir-146b Urinary Bladder Neoplasms Finally, seven micro (mi) RNAs (miR2145p, miR2233p, miR1555p, miR199a3p, miR199b3P, miR146b5p, miR1425p) which were expressed differentially in at least three mutant genes and were positively correlated with M2 macrophage infiltration as well as expressed highly in high grade bladder cancer were identified. +other 31233191 hsa-mir-199a Urinary Bladder Neoplasms Finally, seven micro (mi) RNAs (miR2145p, miR2233p, miR1555p, miR199a3p, miR199b3P, miR146b5p, miR1425p) which were expressed differentially in at least three mutant genes and were positively correlated with M2 macrophage infiltration as well as expressed highly in high grade bladder cancer were identified. +other 31233191 hsa-mir-199b Urinary Bladder Neoplasms Finally, seven micro (mi) RNAs (miR2145p, miR2233p, miR1555p, miR199a3p, miR199b3P, miR146b5p, miR1425p) which were expressed differentially in at least three mutant genes and were positively correlated with M2 macrophage infiltration as well as expressed highly in high grade bladder cancer were identified. +other 31233191 hsa-mir-142 Urinary Bladder Neoplasms Finally, seven micro (mi) RNAs (miR2145p, miR2233p, miR1555p, miR199a3p, miR199b3P, miR146b5p, miR1425p) which were expressed differentially in at least three mutant genes and were positively correlated with M2 macrophage infiltration as well as expressed highly in high grade bladder cancer were identified. +genetics_overexpression_promote 31232941 hsa-mir-222 Thyroid Cancer, Papillary CONCLUSION: In the present study, we demonstrated that miR-222 overexpression was correlated with advanced features like capsular invasion, vascular invasion, larger tumor size and lymph node metastasis in PTCs. +other 31232491 hsa-mir-29 Uterine Cervical Neoplasms Based on all these experiments, TP73-AS1 regulates ARF1 expression by competitively binding with miR3p, thus regulating cervical cancer progression. +lncRNA target 31232476 hsa-mir-103 Atherosclerosis Thus, miR-103 depletion restrains the progression of AS through blocking PTEN-mediated MAPK signaling. +genetics_overexpression_promote 31232474 hsa-mir-448 Carcinoma, Hepatocellular MAGEA6 silencing or miR-448 overexpression was demonstrated to inhibit the abilities of sphere formation, colony formation, cell migration, and invasion of HCC cells. +genetics_knock down_promote 31232177 hsa-mir-124 Carcinoma, Non-Small-Cell Lung Mechanistically, we uncovered that autophagy was induced upon loss of circHIPK3 via the MIR124-3p-STAT3-PRKAA/AMPKa axis in STK11 mutant lung cancer cell lines (A549 and H838). +circulation_biomarker_diagnosis_up 31232032 hsa-mir-937 Metabolic Diseases The relative peripheral blood miR-937 level in patients with metabolic disorders and healthy individuals were evaluated by real-time PCR. +other 31232026 hsa-mir-16 Leukemia MicroRNA-16 Regulates Myeloblastosis Oncogene Expression to Affect Differentiation of Acute Leukemia Cells. BACKGROUND This study was designed to evaluate the effects of micro-RNA-16 (miR-16)-regulated expression of myeloblastosis oncogene (MYB) on the differentiation of acute leukemia cells, the expressions of miR-16 and MYB mRNA, and protein in differently differentiated leukemia cells were detected by real-time PCR and western blot. +genetics_GWAS 31232017 hsa-mir-224 Hepatitis B, Chronic Meanwhile, the combination of miR-224 rs188519172 AG GG phenotype and AFP value could improve the prognosis assessment of HBV related HCC. CONCLUSIONS: miR-224 rs188519172 polymorphism is an indicator of liver injury and a novel prognostic biomarker for tumor development and survival of HBV related HCC patients after liver resection. +other 31231851 hsa-mir-100 Urinary Bladder Neoplasms The aim of the current study was to evaluate the potential role of miR-100 and miR-138 as prognostic biomarkers in Ta/T1 non-muscle-invasive bladder cancer (NMIBC). Our results support miR-138 and miR-100 as prognostic biomarkers in patients with NMIBC. +other 31231851 hsa-mir-138 Urinary Bladder Neoplasms The aim of the current study was to evaluate the potential role of miR-100 and miR-138 as prognostic biomarkers in Ta/T1 non-muscle-invasive bladder cancer (NMIBC). Our results support miR-138 and miR-100 as prognostic biomarkers in patients with NMIBC. +circulation_biomarker_diagnosis_up 31231497 hsa-mir-370 Reperfusion Injury, Hepatic Ischemia Injection of MSCs led to the down-regulation of the serum liver enzymes, expression of miR-370 and BAX, up-regulation of Bcl2 as well as the improvement of hepatic histological damage. +other 31231396 hsa-mir-125a Hepatitis, Alcoholic miR-125a-5p is clustered in the genome with other miRNAs inside a host gene, Spaca6, which was also upregulated in PBMCs, as well as isolated monocytes, from AH patients. +circulation_biomarker_prognosis_up 31231239 hsa-mir-186 Acute Coronary Syndrome In conclusion, a distinctive expression signature of serum miR +transcription factor target 31231226 hsa-mir-28 Inflammation We identified a broad spectrum of novel potential miR-328/hnRNP E2 and miR-328 targets involved in regulation of compartment specific cellular processes, such as inflammation or RNA splicing. +exosome 31229922 hsa-mir-26a Prostatic Neoplasms Our data suggest that exosomal miR-26a derived from prostate carcinoma cells had a suppressive effect on the metastasis and tumor growth of prostate carcinoma. +genetics_overexpression_promote 31228941 hsa-mir-96 Ovarian Neoplasms The overexpression of CAV1 abrogated the promotion of miR +other 31228940 hsa-mir-221 Urinary Bladder Neoplasms Colony formation assay and CCK8 assays were conducted to confirm the function of miR-221/222 in METTL3-induced cell growth in bladder cancer. +circRNA target 31228937 hsa-mir-130b Urinary Bladder Neoplasms Mechanistically, circSLC8A1 could directly interact with miR-130b/miR-494, and subsequently act as a miRNA sponge to regulate the expression of the miR-130b/miR-494 target gene PTEN and downstream signaling pathway, which suppressed the progression of bladder cancer. CONCLUSIONS: CircSLC8A1 acts as a tumor suppressor by a novel circSLC8A1/miR-130b, miR-494/PTEN axis, which may provide a potential biomarker and therapeutic target for the management of bladder cancer. +circRNA target 31228937 hsa-mir-494 Urinary Bladder Neoplasms Mechanistically, circSLC8A1 could directly interact with miR-130b/miR-494, and subsequently act as a miRNA sponge to regulate the expression of the miR-130b/miR-494 target gene PTEN and downstream signaling pathway, which suppressed the progression of bladder cancer. CONCLUSIONS: CircSLC8A1 acts as a tumor suppressor by a novel circSLC8A1/miR-130b, miR-494/PTEN axis, which may provide a potential biomarker and therapeutic target for the management of bladder cancer. +transcription factor target 31228813 hsa-mir-21 autoimmune uveitis Therefore, we demonstrate that miR5p can serve as a therapeutic target in the management of uveitis and other autoimmune diseases. +lncRNA target 31228597 hsa-mir-124 Neuroblastoma Therefore, we speculated that NEAT1 may regulate MPP(+) induced neuronal injury by targeting miR-124 in SH-SY5Y cells. +transcription factor target 31228514 hsa-mir-122 Atherosclerosis Together, these results may identify miR-122 as a novel regulator in EC apoptosis, which offers it as a possible target for therapeutic interventions of atherosclerosis. +genetics_overexpression_promote 31228307 hsa-mir-543 Prostatic Neoplasms Our data showed the overexpression of HGC11-inhibited PI3K/AKT signaling pathway by downregulating miR-543 expression, resulting in the suppression of cell growth in PCa. +lncRNA target 31227976 hsa-mir-19b Inflammation MiR-19b-3p was significantly decreased in OA chondrocytes and IL-1beta-stimulated ATDC5 cells, in paralleled with the elevated type-II-collagen, aggrecan, MMP13 and GRK6 expression. Collectively, miR-19b-3p attenuated OA by targeting GRK6-NF-kappaB pathway. +other 31227612 hsa-mir-144 Myocardial Infarction In conclusion, the expression of MALAT1 was increased, whereas miR-144 expression was down-regulated in the myocardium after AMI. +transcription factor target 31227395 hsa-mir-215 Mesothelioma 5p, and suppression of diverse gene targets associated with cell cycle dynamics not previously drug treatable in MPM clinical studies. +lncRNA target 31227006 hsa-mir-126 Melanoma CONCLUSIONS: Strategies restoring miR3p expression or targeting VEGF-A or ADAM9 could restrain growth and metastasis of dabrafenib-resistant melanomas and increase their drug sensitivity. +epigenetics 31226958 hsa-mir-124 Esophageal Squamous Cell Carcinoma 3p expression in ESCC, which involves in the hypermethylation-silencing regulation mediated by DNA methyltransferase 1(DNMT1), which is of high expression in ESCC tissues and cell lines in the present study. +transcription factor target 31226636 hsa-mir-96 Placenta Diseases Collectively, we determined how miR5p mediates TiO(2) NP-induced placental dysfunction, and provided a potential rescue target for future therapy. +other 31226635 hsa-mir-130a Ischemic Stroke In addition, re-expression of miR-130a yielded an obvious reduction in MCAO-induced infarct volume and neurological deficits in rats. +circRNA target 31226633 hsa-mir-6893 Uterine Cervical Neoplasms More importantly, the bioinformatic results showed the dysregulated expression patterns of circMTO1, miR-6893 and S100A1 in human clinical cervical cancer tissues. +genetics_knock down_suppress 31226520 hsa-mir-200c late onset Parkinson's disease Our data demonstrate that miR-200c regulates EMT and fibrogenesis in mesothelial cells, and loss of peritoneal miR-200c contributes to PD-associated peritoneal fibrosis. +other 31226473 hsa-mir-124 Parkinson Disease In the present study, we have prepared microRNA(miR)loaded Rabies virus glycoprotein (RVG)29 surface-conjugated polymeric nanoparticles (NPs) to improve neuroinflammation in Parkinson's disease (PD). +other 31226416 hsa-mir-19b Colitis SIGNIFICANCE: In vitro and in vivo experiments showed that GOS have certain anti-colitis effect, and this effect may be achieved by up-regulating miR-19b. +epigenetics 31226325 hsa-mir-181d Glioblastoma This study aimed to analyze the role of microRNA-181d associated with the methylation status of the O(6)-methylguanine methyl transferase (MGMT) gene in Glioblastoma multiforme cancer stem cells subjected to treatment with temozolomide and ionizing radiation. We showed that ionizing radiation and temozolomide reduced the viability of cancer stem cells from GBM patients, as well as modified MGMT gene and miRNA-181d expression in cancer stem cells, suggesting that miRNA-181d interferes in the glioblastoma cancer stem cell response to treatment with temozolomide and ionizing radiation. +other 31226266 hsa-mir-1231 Stomach Neoplasms Mechanistically, we found the negative correlation between circ-DCAF6 and miR-1231/-1256 in GC specimens. +circulation_biomarker_diagnosis_ns 31226136 hsa-mir-203 Dermatitis, Atopic In this study, we, for the first time, report statistically significant increases in expression of phosphodiesterase 4D (PDE4D) gene in peripheral blood mononuclear cells (PBMCs) and miR-203 in plasma from AD dogs compared to healthy controls. +genetics_knock down_promote 31225930 hsa-mir-193b Prostatic Neoplasms Knockdown of miR-193b targets FOXM1 and RRM2 in prostate cancer cells phenocopied overexpression of miR-193b. +genetics_overexpression_promote 31225740 hsa-mir-21 Carcinoma, Hepatocellular Overexpression of miR +genetics_GWAS 31225464 hsa-mir-34a Bronchopulmonary Dysplasia Utilizing genetic loss- and gain- of function strategies, we show that miR34a inhibition ameliorates the pulmonary phenotype of BPD (including BPD-associated pulmonary hypertension), at least in part, via one of the downstream targets of miR34a, namely Angiopoietin1/Tie 2 signaling. +genetics_GWAS 31223622 hsa-mir-499 Arthritis But, we also find miRNA-146 rs2910164 and miRNA-499 rs3746444 polymorphism are associated with inflammatory arthritis in Middle East. +lncRNA target 31223614 hsa-mir-21 Sepsis 3p mediates metabolism and cell fate alterations of TECs via manipulating AKT/CDK2-FOXO1 pathway, and that is crucial in the regulation of energy metabolism of TECs during SAKI. +lncRNA target 31222833 hsa-mir-450b Carcinoma, Hepatocellular Additionally, miR-450b-3p inhibited PGK1 expression and phosphorylation of protein kinase B in HCC cell lines. +other 31222831 hsa-mir-214 Carcinoma, Hepatocellular 5p/JUN interaction pairs may play a vital role in HCC. +other 31222831 hsa-mir-93 Carcinoma, Hepatocellular 5p/JUN interaction pairs may play a vital role in HCC. +genetics_overexpression_promote 31222825 hsa-mir-200c Colorectal Neoplasms The results of Cox regression analyses suggested that overexpressed lncRNA ATB, underexpressed miR-200c, poor tumor differentiation, lymph-vascular invasion, and perineural invasion were symbolic of shortened survival of the patients with CRC (all P < .05). +genetics_overexpression_promote 31222560 hsa-mir-221 Carcinoma, Hepatocellular Overexpression of C1QTNF1-AS1 could downregulate miR +lncRNA target 31222482 hsa-mir-140 Ovarian Neoplasms In conclusion, viability, metabolism, and cell cycle of ovarian cancers are regulated by the FOXO4/PVT1/miR-140 signaling pathway. +transcription factor target 31222113 hsa-mir-221 Diabetes Mellitus, Type 2 The targets of hsa-miR-146b-5p that correlated with its levels were enriched in inflammatory pathways, and the targets of hsa-miR3p were enriched in insulin signaling and T2D pathways. +transcription factor target 31222113 hsa-mir-146b Diabetes Mellitus, Type 2 The targets of hsa-miR-146b-5p that correlated with its levels were enriched in inflammatory pathways, and the targets of hsa-miR3p were enriched in insulin signaling and T2D pathways. +genetics_overexpression_promote 31221815 hsa-mir-26a Arthritis, Rheumatoid Overexpression of miR-26a-5p RA-FLS promoted cells proliferation, G1/S transition, cells invasion, and resisted apoptosis in RA-FLS, whereas it led to contrary effects when inhibiting the expression of miR-26a-5p. +lncRNA target 31221141 hsa-mir-195 Otitis Media We proved that OM inhibited HSC activation through down-regulating the expression of miR-195 and up-regulating Smad7. +other 31221141 hsa-mir-195 Fibrosis TGF-beta/Smad signaling and miR-195 have been proved to paly an important role in hepatic stellate cells (HSCs) activation and liver fibrosis. +lncRNA target 31220581 hsa-mir-211 Breast Neoplasms 5p was also followed by a significant decline in the acetylation status of p53 which was associated with remarkable decreased cell viability and induction of apoptosis in breast cancer cells. +other 31220580 hsa-mir-221 Endometrial Neoplasms miR-221 levels were significantly higher in the OB than NOB patients, and, also in this case, obesity impacted more in the ERalpha(+)/PR(+) group. In this interplay miR-221 seems to be in a nodal point of the regulatory system that is particularly strengthened by the metabolic changes in obesity. +lncRNA target 31220469 hsa-mir-378 Cardiomyopathies In conclusion, the study identifies a novel pro-fibrotic lncRNA, PCFL, and the mechanism involves the direct interaction of PCFL with miR-378, which in turn relieves the inhibition effect of miR-378 on GRB2 and promotes cardiac fibrosis. +circulation_biomarker_diagnosis_ns 31220450 hsa-mir-24 Inflammatory Bowel Diseases In this study, miR-24 was found to be elevated in colonic biopsies and blood samples from ulcerative colitis (UC) patients compared with healthy controls. +lncRNA target 31220419 hsa-mir-98 Lung Neoplasms MiR5p inhibition abrogated the effect of SNHG4 silencing on proliferation and invasion of lung cancer cells. +genetics_GWAS 31219360 hsa-mir-149 Tuberculosis, Pulmonary Aims: We investigated the potential associations among four precursor miRNA SNPs (miR-149 A>G, C>T; miR-196a2 C>T; miR-499 C>T) and both PTB and EPTB. Conclusions: We identified genetic polymorphisms in miR-149 that appear to be associated with susceptibility to both PTB and EPTB within a Chinese population. +genetics_GWAS 31219352 hsa-mir-185 Muscular Dystrophy, Oculopharyngeal In conclusion, genetically modified MSC-derived EVs enriched with miR-185 alleviate inflammatory response, inhibit cell proliferation and angiogenesis, and induce cell apoptosis, suggesting that their potential role as a novel therapeutic option for OPMD. +lncRNA target 31219199 hsa-mir-675 Carcinoma, Non-Small-Cell Lung These finding indicated that COPD (hypoxia)-induced H19 promoted expression of miR-675 associated with NSCLC though target apoptosis-related protein P53, BAX, and Bcl-2. +lncRNA target 31219186 hsa-mir-29 Melanoma Collectively, our results show that miR-329 can suppress the melanoma progression by downregulating HMGB2 via the beta-catenin pathway. +other 31218919 hsa-mir-29a Neuralgia In human, hsa-miR-29a was downregulated in lingual nerve neuromas of patients with higher pain VAS scores (painful group) versus patients with lower pain VAS scores (non-painful). +genetics_overexpression_promote 31218746 hsa-mir-34a Ichthyosis, Lamellar In conclusion, overexpression of miR-34a-5p activated beclin 1 through Bcl-2 inhibition in CIH and participated in CIH-induced autophagy. +other 31218739 hsa-mir-181a Carcinoma, Hepatocellular CONCLUSION: Our findings indicate CCAT1 may play a role in regulating autophagy by sponging miR-181a-5p in HCC. +lncRNA target 31218569 hsa-mir-32 Glioma miR-32 was upregulated and PTEN was downregulated in THP1 cells with the M2 phenotype in the glioma microenvironment. miR-32 negatively modulates PTEN, thereby promoting M2 macrophage transformation through PI3K/AKT signaling, enhancing glioma proliferation and migration abilities. +circulation_biomarker_diagnosis_up 31218232 hsa-mir-20 Diabetic Nephropathies 5p, miR-30e, miR-320e, and miR-3196 were found to be differentially expressed in plasma samples among these three groups: diabetic patients with microalbuminuria, diabetic patients with normoalbuminuria, and healthy controls (P < 0.05). +other 31218232 hsa-mir-155 Diabetic Nephropathies 5p may be involved in the pathogenesis and progression of DN. +circulation_biomarker_diagnosis_up 31218232 hsa-mir-320e Diabetic Nephropathies 5p, miR-30e, miR-320e, and miR-3196 were found to be differentially expressed in plasma samples among these three groups: diabetic patients with microalbuminuria, diabetic patients with normoalbuminuria, and healthy controls (P < 0.05). +other 31218232 hsa-mir-150 Diabetic Nephropathies 5p may be involved in the pathogenesis and progression of DN. +circulation_biomarker_diagnosis_up 31218232 hsa-mir-196 Diabetic Nephropathies 5p, miR-30e, miR-320e, and miR-3196 were found to be differentially expressed in plasma samples among these three groups: diabetic patients with microalbuminuria, diabetic patients with normoalbuminuria, and healthy controls (P < 0.05). +lncRNA target 31218102 hsa-mir-873 Carcinoma, Hepatocellular Collectively, our data uncover a previously unappreciated function of miR-873 in HCC cell metabolism and tumorigenesis, suggesting that targeting miR-873/NDFIP1 axis could be a potential therapeutic strategy for the treatment of HCC patients. +genetics_overexpression_promote 31217935 hsa-mir-29a Nasopharyngeal Carcinoma CONCLUSION: These findings highlighted the tumor suppressive effects of miR-29a on NPC cells, as its overexpression inhibited 5-8F cells viability, migration, and induced apoptosis. +genetics_overexpression_promote 31217935 hsa-mir-29 Nasopharyngeal Carcinoma CONCLUSION: These findings highlighted the tumor suppressive effects of miR-29a on NPC cells, as its overexpression inhibited 5-8F cells viability, migration, and induced apoptosis. +other 31217927 hsa-mir-1 Sialic Acid Storage Disease RESULTS: SD down-regulated pri-miR-1b, miR-1b (P<0.05), and BDNF mRNA (P<0.01) in the hippocampus. CONCLUSION: Our data demonstrated that regular treadmill exercise could reverse the down-regulation of hippocampal miR-1b, which has a probable role in the SD-induced cognitive impairment. +other 31217927 hsa-mir-1 Cognition Disorders CONCLUSION: Our data demonstrated that regular treadmill exercise could reverse the down-regulation of hippocampal miR-1b, which has a probable role in the SD-induced cognitive impairment. +genetics_overexpression_suppress 31217897 hsa-let-7a Carcinosarcoma An inverse correlation was observed between overexpression of HMGA1/2, LIN28A, and MTA1 and downregulation of miRNAs such as let-7a, let-7d, miR26a, miR16, miR214, and miR30c in both UCS and OCS. +genetics_overexpression_suppress 31217897 hsa-mir-214 Carcinosarcoma An inverse correlation was observed between overexpression of HMGA1/2, LIN28A, and MTA1 and downregulation of miRNAs such as let-7a, let-7d, miR26a, miR16, miR214, and miR30c in both UCS and OCS. +genetics_overexpression_suppress 31217897 hsa-mir-16 Carcinosarcoma An inverse correlation was observed between overexpression of HMGA1/2, LIN28A, and MTA1 and downregulation of miRNAs such as let-7a, let-7d, miR26a, miR16, miR214, and miR30c in both UCS and OCS. +genetics_overexpression_suppress 31217897 hsa-let-7d Carcinosarcoma An inverse correlation was observed between overexpression of HMGA1/2, LIN28A, and MTA1 and downregulation of miRNAs such as let-7a, let-7d, miR26a, miR16, miR214, and miR30c in both UCS and OCS. +genetics_overexpression_suppress 31217897 hsa-mir-26a Carcinosarcoma An inverse correlation was observed between overexpression of HMGA1/2, LIN28A, and MTA1 and downregulation of miRNAs such as let-7a, let-7d, miR26a, miR16, miR214, and miR30c in both UCS and OCS. +other 31217870 hsa-mir-21b Reperfusion Injury Recent studies have shown abnormal expression levels of cyclooxygenase-2 (COX-2) and miR-21b-3p in cerebral ischemia-reperfusion (I/R) rat models. +lncRNA target 31217870 hsa-mir-21b Brain Injuries Decreased COX-2 expression could reduce brain injury and thus could be a target of miR-21b-3p according to the miRNA databases (miRDB) analysis. +other 31217870 hsa-mir-21 Reperfusion Injury Recent studies have shown abnormal expression levels of cyclooxygenase-2 (COX-2) and miR-21b-3p in cerebral ischemia-reperfusion (I/R) rat models. +lncRNA target 31217870 hsa-mir-21 Brain Injuries Decreased COX-2 expression could reduce brain injury and thus could be a target of miR-21b-3p according to the miRNA databases (miRDB) analysis. +transcription factor target 31217868 hsa-mir-23a Carcinoma, Pancreatic Ductal Collectively, our findings indicate that ECM1 is a proto-oncogene and show that targeting the miR-23a-5p/ECM1 axis may represent a promising therapeutic strategy for PDAC. +genetics_knock down_suppress 31217855 hsa-mir-613 Carcinoma, Hepatocellular In vivo experiment also revealed that RMRP knockdown inhibited HCC tumorigenesis, while miR-613 silencing could partly reversed the inhibitory effect of RMRP knockdown on HCC tumorigenesis. +circulation_biomarker_diagnosis_down 31217548 hsa-mir-144 Endometriosis 3p may be derived from exogenous sources such as the circulation/erythrocytes. +circulation_biomarker_diagnosis_down 31216670 hsa-mir-525 Hypertension, Pregnancy-Induced 5p) for the diagnosis of GH and PE was significantly higher in the case of expression profiling of maternal plasma exosomes compared to expression profiling of the whole maternal plasma samples. +circulation_biomarker_diagnosis_down 31216670 hsa-mir-525 Fetal Growth Retardation 5p) for the diagnosis of GH and PE was significantly higher in the case of expression profiling of maternal plasma exosomes compared to expression profiling of the whole maternal plasma samples. +circulation_biomarker_diagnosis_down 31216670 hsa-mir-525 Pre-Eclampsia 5p) for the diagnosis of GH and PE was significantly higher in the case of expression profiling of maternal plasma exosomes compared to expression profiling of the whole maternal plasma samples. +circulation_biomarker_diagnosis_down 31216670 hsa-mir-520a Hypertension, Pregnancy-Induced 5p) for the diagnosis of GH and PE was significantly higher in the case of expression profiling of maternal plasma exosomes compared to expression profiling of the whole maternal plasma samples. +circulation_biomarker_diagnosis_down 31216670 hsa-mir-520a Pre-Eclampsia 5p) for the diagnosis of GH and PE was significantly higher in the case of expression profiling of maternal plasma exosomes compared to expression profiling of the whole maternal plasma samples. +circulation_biomarker_diagnosis_down 31216670 hsa-mir-520a Fetal Growth Retardation 5p) for the diagnosis of GH and PE was significantly higher in the case of expression profiling of maternal plasma exosomes compared to expression profiling of the whole maternal plasma samples. +circulation_biomarker_diagnosis_down 31216670 hsa-mir-517 Hypertension, Pregnancy-Induced 5p) for the diagnosis of GH and PE was significantly higher in the case of expression profiling of maternal plasma exosomes compared to expression profiling of the whole maternal plasma samples. +circulation_biomarker_diagnosis_down 31216670 hsa-mir-517 Pre-Eclampsia 5p) for the diagnosis of GH and PE was significantly higher in the case of expression profiling of maternal plasma exosomes compared to expression profiling of the whole maternal plasma samples. +circulation_biomarker_diagnosis_down 31216670 hsa-mir-517 Fetal Growth Retardation 5p) for the diagnosis of GH and PE was significantly higher in the case of expression profiling of maternal plasma exosomes compared to expression profiling of the whole maternal plasma samples. +lncRNA target 31216648 hsa-mir-200b Endometrial Neoplasms The analysis showed that 114 miRNAs were significantly dysregulated in EC patients, among which eight miRNAs, miRNA5p, miRNA-10b-5p, miRNA-34c-3p, miRNA-449b-5p, miRNA-34c-5p, miRNA-200b-3p, miRNA-2110, and miRNA-34b-3p, demonstrated a classification performance at area under the receiver operating characteristic curve (AUC) values above 0.9. +lncRNA target 31216648 hsa-mir-34c Endometrial Neoplasms The analysis showed that 114 miRNAs were significantly dysregulated in EC patients, among which eight miRNAs, miRNA5p, miRNA-10b-5p, miRNA-34c-3p, miRNA-449b-5p, miRNA-34c-5p, miRNA-200b-3p, miRNA-2110, and miRNA-34b-3p, demonstrated a classification performance at area under the receiver operating characteristic curve (AUC) values above 0.9. +lncRNA target 31216648 hsa-mir-449b Endometrial Neoplasms The analysis showed that 114 miRNAs were significantly dysregulated in EC patients, among which eight miRNAs, miRNA5p, miRNA-10b-5p, miRNA-34c-3p, miRNA-449b-5p, miRNA-34c-5p, miRNA-200b-3p, miRNA-2110, and miRNA-34b-3p, demonstrated a classification performance at area under the receiver operating characteristic curve (AUC) values above 0.9. +lncRNA target 31216648 hsa-mir-10b Endometrial Neoplasms The analysis showed that 114 miRNAs were significantly dysregulated in EC patients, among which eight miRNAs, miRNA5p, miRNA-10b-5p, miRNA-34c-3p, miRNA-449b-5p, miRNA-34c-5p, miRNA-200b-3p, miRNA-2110, and miRNA-34b-3p, demonstrated a classification performance at area under the receiver operating characteristic curve (AUC) values above 0.9. +lncRNA target 31216648 hsa-mir-383 Endometrial Neoplasms The analysis showed that 114 miRNAs were significantly dysregulated in EC patients, among which eight miRNAs, miRNA5p, miRNA-10b-5p, miRNA-34c-3p, miRNA-449b-5p, miRNA-34c-5p, miRNA-200b-3p, miRNA-2110, and miRNA-34b-3p, demonstrated a classification performance at area under the receiver operating characteristic curve (AUC) values above 0.9. +lncRNA target 31216648 hsa-mir-2110 Endometrial Neoplasms The analysis showed that 114 miRNAs were significantly dysregulated in EC patients, among which eight miRNAs, miRNA5p, miRNA-10b-5p, miRNA-34c-3p, miRNA-449b-5p, miRNA-34c-5p, miRNA-200b-3p, miRNA-2110, and miRNA-34b-3p, demonstrated a classification performance at area under the receiver operating characteristic curve (AUC) values above 0.9. +other 31216561 hsa-mir-144 Colorectal Neoplasms CONCLUSIONS: The stool levels of miR-92a and miR-144* showed good sensitivity and fair specificity for detection of CRC, and thus may be useful as noninvasive biomarkers for this disease. +other 31216561 hsa-mir-92 Colorectal Neoplasms CONCLUSIONS: The stool levels of miR-92a and miR-144* showed good sensitivity and fair specificity for detection of CRC, and thus may be useful as noninvasive biomarkers for this disease. +other 31216561 hsa-mir-92a Colorectal Neoplasms CONCLUSIONS: The stool levels of miR-92a and miR-144* showed good sensitivity and fair specificity for detection of CRC, and thus may be useful as noninvasive biomarkers for this disease. +lncRNA target 31216479 hsa-mir-124 Zika Virus Infection Bioinformatics analysis of Argonaute-bound RNAs in ZIKV-infected hNSCs identified a number of miRNAs with predicted involvement in microcephaly, including miR3p, which dysregulates NSC maintenance through repression of the transferrin receptor (TFRC). +transcription factor target 31215650 hsa-mir-18b Breast Neoplasms Furthermore, the underlying functional experiments demonstrated that AC073284.4 might sponge miR-18b-5p to attenuate the invasion, metastasis, and EMT of BC cell through upregulating DOCK4 expression. In summary, AC073284.4 might serve as a competing endogenous RNA (ceRNA) in BC progression via modulating miR-18b-5p/DOCK4 axis, which weakens EMT and migration of BC. +other 31215527 hsa-mir-24 Polycystic Ovary Syndrome CONCLUSIONS miR-324 regulates the proliferation of KGN cells in PCOs and be essential in the management of PCOS. +lncRNA target 31215481 hsa-mir-7 Small Cell Lung Carcinoma 5p impeded Dox-induced HR repair by inhibiting the expression of HR repair factors (Rad51 and BRCA1) that resulted in resensitizing SCLC cells to doxorubicin. +genetics_overexpression_suppress 31215474 hsa-mir-30 Carotid Stenosis The overexpression of miRNA +transcription factor target 31215466 hsa-mir-34a Bone Diseases miR-34a-targeted therapy might be a promising strategy for promoting the reconstruction of bone defects after radiotherapy. +other 31215466 hsa-mir-34a Radiation Injuries In situ delivery of miR-34a promoted bone regeneration in irradiated bone defects. +other 31215169 hsa-mir-219a Triple Negative Breast Neoplasms Increased BIRC3 and decreased miR-219a-5p were observed in TNBC tissues and cell lines. Our study suggested that lncRNA HCP5 promotes TNBC progression as a ceRNA to regulate BIRC3 by sponging miR-219a-5p. +other 31214962 hsa-mir-9 Urinary Bladder Neoplasms This study suggests the clinical value of miR-9 as a prognostic factor in bladder cancer after tumor resection. +other 31214773 hsa-mir-506 Pulmonary Fibrosis We observed miR-506 downregulation in lung tissues during lung fibrosis after ARDS rat modeling by LPS exposure. Our findings revealed that miR-506 could be an important modulator of apoptosis and inflammation and a regulator of lung fibrosis. +lncRNA target 31214736 hsa-mir-940 Squamous Cell Carcinoma of Head and Neck In conclusion, our data demonstrated that miR-940/CXCR2 system regulated the metastasis of TSCC cells via NF-kappaB-induced EMT process. +other 31214616 hsa-mir-221 Carcinoma, Hepatocellular Taken together, our findings implied that miR-221 could be a potential candidate for the therapeutics of HCC metastasis. +other 31214610 hsa-mir-8061 Parkinson Disease Further functional assays suggest that rs2015 may affect the expression of SIRT2 by affecting the binding of miR-8061 to the 3'UTR of SIRT2, ultimately contributing to the risk of PD. +other 31214494 hsa-mir-34b nonpapillary renal cell carcinoma 5p, miRNA-429, miRNA-200a-3p and miRNA-200b-3p, in 96 samples of ccRCCs using the TaqMan real-time PCR method. +other 31214494 hsa-mir-155 nonpapillary renal cell carcinoma 5p, miRNA-429, miRNA-200a-3p and miRNA-200b-3p, in 96 samples of ccRCCs using the TaqMan real-time PCR method. +other 31214494 hsa-mir-210 nonpapillary renal cell carcinoma 5p, miRNA-429, miRNA-200a-3p and miRNA-200b-3p, in 96 samples of ccRCCs using the TaqMan real-time PCR method. +other 31214494 hsa-mir-106b nonpapillary renal cell carcinoma 5p, miRNA-429, miRNA-200a-3p and miRNA-200b-3p, in 96 samples of ccRCCs using the TaqMan real-time PCR method. +other 31214494 hsa-mir-200a nonpapillary renal cell carcinoma 5p, miRNA-429, miRNA-200a-3p and miRNA-200b-3p, in 96 samples of ccRCCs using the TaqMan real-time PCR method. +other 31214494 hsa-mir-106a nonpapillary renal cell carcinoma 5p, miRNA-429, miRNA-200a-3p and miRNA-200b-3p, in 96 samples of ccRCCs using the TaqMan real-time PCR method. +other 31214494 hsa-mir-200b nonpapillary renal cell carcinoma 5p, miRNA-429, miRNA-200a-3p and miRNA-200b-3p, in 96 samples of ccRCCs using the TaqMan real-time PCR method. +other 31214494 hsa-mir-429 nonpapillary renal cell carcinoma 5p, miRNA-429, miRNA-200a-3p and miRNA-200b-3p, in 96 samples of ccRCCs using the TaqMan real-time PCR method. +other 31214494 hsa-mir-122 nonpapillary renal cell carcinoma 5p, miRNA-429, miRNA-200a-3p and miRNA-200b-3p, in 96 samples of ccRCCs using the TaqMan real-time PCR method. +other 31214494 hsa-mir-135a nonpapillary renal cell carcinoma The cutoff value of miRNA-135a-5p expression to identify the association of an altered level of miRNA-135a-5p with metachronous metastasis in ccRCCs was determined and showed excellent specificity. +genetics_GWAS 31214179 hsa-mir-146 Arbovirus Infections Conclusions: Major epigenetic alterations found on arboviruses infections were miR-146, miR-30e and the Dicer complex. +virus_miRNA 31213914 kshv-mir-k12-1 Sarcoma, Kaposi kshv-mir-k12-1-5p promotes cell growth and metastasis by targeting SOCS6 in Kaposi's sarcoma cells +genetics_overexpression_promote 31213904 hsa-mir-193a Carcinoma, Pancreatic Ductal Moreover, CCND1 expression was significantly lower in PDAC cells with an overexpression of miR-193a-3p. +lncRNA target 31213898 hsa-mir-29c Stomach Neoplasms We found that microRNA-29c-3p could directly target COL1A1 and COL4A1 in BGC-823 cells. +transcription factor target 31213897 hsa-mir-143 Uveal melanoma Conclusion: miR3p is a potential therapeutic target to treat UM since overriding its declines in expression that occur in this disease reversed the pathogenesis of this disease. +transcription factor target 31213841 hsa-mir-29a Thyroid Cancer, Papillary Conclusion: miR-29a inhibits proliferation, migration, and invasion of PTC by targeting DPP4, which might provide a new target for clinical treatment of PTC. +genetics_GWAS 31213825 hsa-mir-34b Esophageal Squamous Cell Carcinoma Conclusion: Our results suggested that the polymorphisms of miR-196a and miR-34b/c genes were related to the risk of ESCC, especially among Chinese. +genetics_GWAS 31213825 hsa-mir-196a Esophageal Squamous Cell Carcinoma However, the associations between several previously reported miR-SNPs, including miR-196a2 rs11614913, miR-146a rs2910164, miR-34b/c rs4938723, and miR-423 rs6505162 and the susceptibility of esophageal squamous cell carcinoma (ESCC) remain controversial. +genetics_GWAS 31213825 hsa-mir-423 Esophageal Squamous Cell Carcinoma However, the associations between several previously reported miR-SNPs, including miR-196a2 rs11614913, miR-146a rs2910164, miR-34b/c rs4938723, and miR-423 rs6505162 and the susceptibility of esophageal squamous cell carcinoma (ESCC) remain controversial. +genetics_GWAS 31213825 hsa-mir-146a Esophageal Squamous Cell Carcinoma However, the associations between several previously reported miR-SNPs, including miR-196a2 rs11614913, miR-146a rs2910164, miR-34b/c rs4938723, and miR-423 rs6505162 and the susceptibility of esophageal squamous cell carcinoma (ESCC) remain controversial. +genetics_knock down_suppress 31213582 hsa-mir-214 Pancreatic Carcinoma 5p inhibitor reversed the effects of DANCR knockdown on PC cells. +lncRNA target 31213574 hsa-mir-141 Pancreatic Carcinoma 5p/TGF-beta2 axis. +genetics_overexpression_suppress 31213131 hsa-mir-337 Lymphoma, T-Cell, Cutaneous Overexpression of STAT3 counteracted the pro-apoptotic influence of miR-337 in CTCL cell lines and restored their invasion properties. +lncRNA target 31213092 hsa-mir-451 Glioma Conclusion: Down-regulation of LSINCT5 represses glioma cells growth and metastasis in vitro likely through targeting miR-451 and thereby inhibiting Rac1-regulated PI3K/AKT, Wnt/beta-catenin and NF-kappaB pathways. +other 31213064 hsa-mir-148a Zika Virus Infection The induction of miR-145 and miR-148a was confirmed in postmortem brain samples from stillborn with severe CZS. +other 31213064 hsa-mir-145 Zika Virus Infection The induction of miR-145 and miR-148a was confirmed in postmortem brain samples from stillborn with severe CZS. +other 31212861 hsa-mir-151a Uveal melanoma 5p, and miR-151a-3p. +other 31212861 hsa-mir-17 Uveal melanoma 5p, and miR-151a-3p. +other 31212861 hsa-mir-21 Uveal melanoma 5p, and miR-151a-3p. +transcription factor target 31212858 hsa-mir-143 Mesothelioma, Malignant Conclusions: 30 wound-healing-related genes were significantly deregulated in MPM, which are potential targets of hsa-miR-143, hsa-miR-223, and the hsa-miR-29 miRNA family members. +transcription factor target 31212858 hsa-mir-223 Mesothelioma, Malignant Conclusions: 30 wound-healing-related genes were significantly deregulated in MPM, which are potential targets of hsa-miR-143, hsa-miR-223, and the hsa-miR-29 miRNA family members. +transcription factor target 31212858 hsa-mir-29 Mesothelioma, Malignant Conclusions: 30 wound-healing-related genes were significantly deregulated in MPM, which are potential targets of hsa-miR-143, hsa-miR-223, and the hsa-miR-29 miRNA family members. +genetics_overexpression_promote 31212131 hsa-mir-96 Uterine Cervical Neoplasms STXBP5-AS1 overexpression significantly reduced CC cells proliferation and invasion ability by suppressing miR +lncRNA target 31211984 hsa-mir-744 Adenocarcinoma of Lung 5p/MAFG axis in LUAD, providing a potent and promising therapeutic target for LUAD patients. +circulation_biomarker_diagnosis_ns 31211948 hsa-mir-221 Depressive Disorder Our results indicate that elevated serum miR +lncRNA target 31211901 hsa-mir-146a Sepsis MicroRNA-146a, a newly identified proinflammatory mediator that is upregulated during sepsis, induced TF production via a TLR7-dependent mechanism. +lncRNA target 31211901 hsa-mir-146a Blood Coagulation Disorders MicroRNA-146a, a newly identified proinflammatory mediator that is upregulated during sepsis, induced TF production via a TLR7-dependent mechanism. +other 31211843 hsa-mir-23a Muscular Atrophy, Spinal These experiments demonstrate that miR-23a is a novel protective modifier of SMA, warranting further characterization of miRNA dysfunction in SMA. +other 31211843 hsa-mir-23a Muscular Atrophy From this array, miR-23a downregulation was identified selectively in SMA motor neurons, consistent with previous reports where miR-23a functioned in neuroprotective and muscle atrophy-antagonizing roles. +genetics_GWAS 31211819 hsa-mir-21 psoriasis 1 CONCLUSION: SNP rs4597342 in 3'UTR of ITGAM influencing miR-21 binding may be considered a risk factor for psoriasis development. Upregulated miR-21 in psoriasis is likely to inhibit CD11b production in the case of the rs4597342 T allele which may lead to Mac-1 dysfunction, resulting in an aberrant function of innate immune cells and leading to the production of cytokines involved in psoriasis pathogenesis. +other 31210410 hsa-mir-150 Carcinoma, Hepatocellular The current study elucidated the role of a long non-coding RNA (lncRNA), FOXD2-AS1, in the pathogenesis of hepatocellular carcinoma (HCC) and the regulatory mechanism underlying FOXD2-AS1/miR5p/transmembrane protein 9 (TMEM9) signalling in HCC. +transcription factor target 31210354 hsa-mir-1908 Lyme Disease Except for the known miRNA hsa-miR-1908 regulating adipogenesis, five miRNAs, including hsa-miR-146a-3p, hsa-miR-4495, hsa-miR-4663, hsa-miR-6069, and hsa-miR3p are the latest potential biomarkers for LD formation, targeting ACSL1, APOB, METTL7A, PLIN1, and PLIN4. +transcription factor target 31210354 hsa-mir-146a Lyme Disease Except for the known miRNA hsa-miR-1908 regulating adipogenesis, five miRNAs, including hsa-miR-146a-3p, hsa-miR-4495, hsa-miR-4663, hsa-miR-6069, and hsa-miR3p are the latest potential biomarkers for LD formation, targeting ACSL1, APOB, METTL7A, PLIN1, and PLIN4. +transcription factor target 31210354 hsa-mir-6069 Lyme Disease Except for the known miRNA hsa-miR-1908 regulating adipogenesis, five miRNAs, including hsa-miR-146a-3p, hsa-miR-4495, hsa-miR-4663, hsa-miR-6069, and hsa-miR3p are the latest potential biomarkers for LD formation, targeting ACSL1, APOB, METTL7A, PLIN1, and PLIN4. +transcription factor target 31210354 hsa-mir-4663 Lyme Disease Except for the known miRNA hsa-miR-1908 regulating adipogenesis, five miRNAs, including hsa-miR-146a-3p, hsa-miR-4495, hsa-miR-4663, hsa-miR-6069, and hsa-miR3p are the latest potential biomarkers for LD formation, targeting ACSL1, APOB, METTL7A, PLIN1, and PLIN4. +transcription factor target 31210354 hsa-mir-4495 Lyme Disease Except for the known miRNA hsa-miR-1908 regulating adipogenesis, five miRNAs, including hsa-miR-146a-3p, hsa-miR-4495, hsa-miR-4663, hsa-miR-6069, and hsa-miR3p are the latest potential biomarkers for LD formation, targeting ACSL1, APOB, METTL7A, PLIN1, and PLIN4. +transcription factor target 31210354 hsa-mir-675 Lyme Disease Except for the known miRNA hsa-miR-1908 regulating adipogenesis, five miRNAs, including hsa-miR-146a-3p, hsa-miR-4495, hsa-miR-4663, hsa-miR-6069, and hsa-miR3p are the latest potential biomarkers for LD formation, targeting ACSL1, APOB, METTL7A, PLIN1, and PLIN4. +other 31210353 hsa-mir-146a Carcinoma, Hepatocellular 5p, miR-500a*, and miR-550a*) was identified as a predictor for HCC PFS (p < .0001; HR = 2.608). +other 31210353 hsa-mir-31 Carcinoma, Hepatocellular 5p, miR-500a*, and miR-550a*) was identified as a predictor for HCC PFS (p < .0001; HR = 2.608). +other 31210353 hsa-mir-550a Carcinoma, Hepatocellular 5p, miR-500a*, and miR-550a*) was identified as a predictor for HCC PFS (p < .0001; HR = 2.608). +other 31210353 hsa-mir-500a Carcinoma, Hepatocellular 5p, miR-500a*, and miR-550a*) was identified as a predictor for HCC PFS (p < .0001; HR = 2.608). +other 31210353 hsa-mir-193a Carcinoma, Hepatocellular 5p, miR-500a*, and miR-550a*) was identified as a predictor for HCC PFS (p < .0001; HR = 2.608). +other 31210353 hsa-mir-127 Carcinoma, Hepatocellular 5p, miR-500a*, and miR-550a*) was identified as a predictor for HCC PFS (p < .0001; HR = 2.608). +other 31210353 hsa-mir-152 Carcinoma, Hepatocellular 5p, miR-500a*, and miR-550a*) was identified as a predictor for HCC PFS (p < .0001; HR = 2.608). +lncRNA target 31210338 hsa-mir-139 Cerebral Hemorrhage CONCLUSIONS: MF protects ICH in rats by inhibiting oxidative stress and inflammatory response through activating microRNA-139/Nrf2 axis. +lncRNA target 31210336 hsa-mir-146a Spinal Cord Injuries CONCLUSIONS: MiR-146a can promote the repair of SCI and reduce inflammatory responses in rats through the TLR/NF-kappaB signaling pathway. +genetics_overexpression_suppress 31210328 hsa-mir-488 Myocardial Infarction, Acute Overexpression of ZNF791 reversed the protective role of miRNA +lncRNA target 31210327 hsa-mir-21 Hypertension CONCLUSIONS: MiR-21 is involved in regulating the pathological symptoms and myocardial cell apoptosis in hypertensive rats through the PTEN/PI3K/Akt/mTOR signaling pathway. +lncRNA target 31210326 hsa-mir-548c Myocardial Fibrosis CONCLUSIONS: MiR-548c-3p could improve myocardial fibrosis by targeting c-Myb. +transcription factor target 31210325 hsa-mir-182 Heart Failure OBJECTIVE: To investigate the effect of miRNA-182 on cardiomyocyte apoptosis of heart failure (HF). CONCLUSIONS: MiRNA-182 inhibits cardiomyocyte apoptosis induced by non-ischemic HF via downregulating PDCD4 and PACS2. +lncRNA target 31210323 hsa-mir-130a Cerebral Hemorrhage CONCLUSIONS: MiR-130a promotes neuronal growth in brain tissues in ICH rats and alleviates neuronal injury after ICH through the PTEN/PI3K/AKT signaling pathway. +genetics_overexpression_suppress 31210322 hsa-mir-23b Cerebral Hemorrhage Additionally, the functional assays demonstrated that miR-23b overexpression obviously repressed CC cell proliferation, invasion and migration abilities through the regulation of the AKT/mTOR pathway and the epithelial-to-mesenchymal transition (EMT) progress. +lncRNA target 31210320 hsa-mir-223 Inflammatory Bowel Diseases OBJECTIVE: The aim of this study was to explore the regulatory mechanism of micro ribonucleic acid (miR)-223 in ulcerative colitis (UC) through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)-mammalian target of rapamycin (mTOR) signaling pathway. CONCLUSIONS: MiR-223 can trigger cell apoptosis and inflammation in UC by up-regulating the PI3K/Akt-mTOR signaling pathway. +lncRNA target 31210318 hsa-mir-193a Arthritis, Rheumatoid CONCLUSIONS: MicroRNA-193a-3p is highly expressed in the synovial tissues and cells of rheumatoid arthritis. +genetics_overexpression_suppress 31210317 hsa-mir-485 Leukemia, Myeloid, Acute Overexpression of miRNA +genetics_overexpression_suppress 31210312 hsa-mir-621 Carcinoma, Non-Small-Cell Lung Overexpression of SIX4 partially reversed the role of miRNA-621 in the malignant progression of NSCLC. +genetics_overexpression_promote 31210305 hsa-mir-93 Stomach Neoplasms 5p overexpression in GC cells upregulated downstream genes in Hippo pathway, including CDX2, FOXM1 and CTGF. +lncRNA target 31210303 hsa-mir-137 Spinal Cord Injuries 5p exerts an anti-inflammatory response by upregulating IL-10R1, thus improving locomotor function and alleviating spinal cord injury. +lncRNA target 31210300 hsa-mir-375 Colorectal Neoplasms RECK was predicted to be the target of microRNA-375, which was downregulated in CRC tissues and cells. +other 31210297 hsa-mir-103 Carcinoma, Hepatocellular In addition, TP73-AS1 could accelerate the proliferation of HCC cells by regulating microRNA-103. +genetics_overexpression_promote 31210295 hsa-mir-23b Uterine Cervical Neoplasms Additionally, the functional assays demonstrated that miR-23b overexpression obviously repressed CC cell proliferation, invasion and migration abilities through the regulation of the AKT/mTOR pathway and the epithelial-to-mesenchymal transition (EMT) progress. +lncRNA target 31210292 hsa-mir-99a Ovarian Neoplasms CONCLUSIONS: miR-99a suppressed the proliferation through AKT/mTOR signaling pathway and the invasion-mediated EMT in ovarian cancer. +lncRNA target 31210288 hsa-mir-765 Osteosarcoma Furthermore, miR-765 was involved in tumorigenesis of OS through activating extracellular-signal-regulated kinase/ epithelial-mesenchymal transition (ERK/EMT) pathway. +other 31210286 hsa-mir-20b Femur Head Necrosis RESULTS: Compared with those in the control group, the bone trabecula was sparse, the number of osteocytes significantly declined and the number of apoptotic osteocytes markedly increased (p<0.01); the expression level of miR-20b in bone tissues remarkably increased (p<0.01), the content of interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor-alpha (TNF-alpha) in bone tissues increased (p<0.01), the content of IL-10 significantly declined (p<0.01), the expression level of cleaved caspase-3 protein in bone tissues markedly increased (p<0.01), the Bcl-2/Bax expression level evidently declined (p<0.01) and the expression levels of anaplastic lymphoma kinase3 (ALK3), GATA4 and NKX2.5 in bone tissues remarkably increased (p<0.01) in the model group. +lncRNA target 31210282 hsa-mir-124 Spinal Cord Injuries CONCLUSIONS: MiR-124 inhibits neuronal apoptosis in SCI by binding to GCH1. The results in the present study may provide a new mechanism for the therapeutic effect of miR-124, and miR-124 may have a potential therapeutic value in the treatment of SCI in the future. +lncRNA target 31210281 hsa-mir-1297 Osteoporosis OBJECTIVE: This study was designed to investigate whether microRNA-1297 can regulate the osteogenesis of bone marrow mesenchymal stem cells (BMSCs) through WNT5A, thus influencing the progression of osteoporosis. +genetics_overexpression_promote 31209892 hsa-mir-33a Colorectal Neoplasms We first confirmed that miR-33a-5p in CRC tissues and cell lines were downregulated (P < 0.05), and that the proliferation, clone formation capacities, G1/S progression, and migration capacities of the two CRC cell lines HCT116 cells and HT29 were suppressed by miR-33a-5p overexpression in vitro (P < 0.05). +other 31209454 hsa-mir-223 Inflammatory Bowel Diseases In a larger cohort, active UC patients displayed significantly higher levels of miR-223 and miR-1246 than controls while patients with CDI had higher levels of faecal miR-1246 but not miR-223. +other 31209454 hsa-mir-1246 Inflammatory Bowel Diseases In a larger cohort, active UC patients displayed significantly higher levels of miR-223 and miR-1246 than controls while patients with CDI had higher levels of faecal miR-1246 but not miR-223. +lncRNA target 31209222 hsa-mir-665 Breast Neoplasms Our study demonstrates that miR-665 upregulation is associated with metastasis and poor survival in BC patients, and mechanistically, miR-665 enhances progression of BC via NR4A3/MEK signaling pathway. +exosome 31209202 hsa-mir-199a Sarcoma, Ewing Investigation of the miRNA content of CD99-deprived EXOs identified miR-199a-3p as a key driver able to reverse EWS malignancy in experimental models as well as in clinical specimens. +circulation_biomarker_diagnosis_ns 31209193 hsa-mir-148a Lupus Nephritis METHODS: The aim of this study was to investigate the diagnostic values of circulating miR-21, miR-148a, miR-150, and miR-423 involved in autoimmunity and kidney fibrosis in plasma samples of LN cases (N = 26) and healthy controls (N = 26) using quantitative- PCR (qPCR). +circulation_biomarker_diagnosis_ns 31209193 hsa-mir-423 Lupus Nephritis METHODS: The aim of this study was to investigate the diagnostic values of circulating miR-21, miR-148a, miR-150, and miR-423 involved in autoimmunity and kidney fibrosis in plasma samples of LN cases (N = 26) and healthy controls (N = 26) using quantitative- PCR (qPCR). +circulation_biomarker_diagnosis_ns 31209193 hsa-mir-150 Lupus Nephritis METHODS: The aim of this study was to investigate the diagnostic values of circulating miR-21, miR-148a, miR-150, and miR-423 involved in autoimmunity and kidney fibrosis in plasma samples of LN cases (N = 26) and healthy controls (N = 26) using quantitative- PCR (qPCR). +circulation_biomarker_diagnosis_ns 31209193 hsa-mir-21 Lupus Nephritis METHODS: The aim of this study was to investigate the diagnostic values of circulating miR-21, miR-148a, miR-150, and miR-423 involved in autoimmunity and kidney fibrosis in plasma samples of LN cases (N = 26) and healthy controls (N = 26) using quantitative- PCR (qPCR). +lncRNA target 31208923 hsa-mir-498 Carcinoma, Hepatocellular CONCLUSIONS: Our data highlighted the tumor suppressor role of miR +genetics_overexpression_promote 31208913 hsa-mir-338 Colorectal Neoplasms Finally, in a xenograft model, overexpressing miR +transcription factor target 31208912 hsa-mir-199a Albuminuria Through a bioinformatic analysis, miR-199a-5p was selected and found to be increased in EVs from HSA-induced HK-2 cells and in urinary EVs from DM patients with macroalbuminuria. +lncRNA target 31208717 hsa-mir-5095 Esophageal Squamous Cell Carcinoma Next, we identified microRNA-5095 (miR-5095) as a target of circRAD23B, and found that miR-5095 was negatively correlated to the expression of circRAD23B in esophageal cancer. +other 31208318 hsa-mir-4728 Breast Neoplasms In the case of HER2-enriched tumors a small set of miRNAs including the HER2-encoded mir-4728 identifies the group with very high specificity. +other 31208279 hsa-mir-25 Carcinoma, Non-Small-Cell Lung Moreover, the up-regulation of miR-25 was associated with poor survival of NSCLC patients and might be used as an independent prognostic factor. +other 31207946 hsa-mir-21 Hepatitis C This miRNA signature correctly classifies HCV-exposed (CHC and SC) vs. HC, with the has-miR3p showing the best performance. +transcription factor target 31207579 hsa-mir-98 Squamous Cell Carcinoma of Head and Neck HMGA-POSTN in LSCC, which is able to reverse EMT and inhibit metastasis, underlining the therapeutic potential of this signal. +other 31207576 hsa-mir-155 Pulmonary Disease, Chronic Obstructive CONCLUSION: LncRNA MIR155HG modulated GM-CSF-mediated M1/M2 macrophage polarization in COPD progression. +circRNA target 31207490 hsa-mir-125a Thyroiditis, Autoimmune The expression of miR-125a-3p was decreased in the HT patients and correlated inversely with an elevated level of hsa_circ_0089172. Taken together, these results demonstrate that hsa_circ_0089172 as a potential diagnostic biomarker of HT and may play a crucial role in the pathogenesis of HT via sponging miR-125a-3p. +genetics_overexpression_promote 31207321 hsa-mir-130a Esophageal Squamous Cell Carcinoma HOTAIR may act as a competing endogenous RNA and could effectively becoming a sponge for miR-130a-5p, thereby modulating the derepression of ZEB1 and promoting epithelial-mesenchymal transition in ESCC. HOTAIR overexpression may promote tumor invasiveness and progression in ESCC, given that HOTAIR functions as a miR-130a-5p sponge, positively regulating ZEB1. +other 31207319 hsa-mir-1307 Carcinoma, Hepatocellular Overall, hsa_circ_0091570 sponge miR-1307 as a ceRNA and regulate ISM1 expression by exerting functional roles in HCC. +lncRNA target 31207222 hsa-mir-374a Breast Neoplasms CONCLUSION: We found that NEF possessed the anti-growth and anti-metastasis effect on MDA-MB-231cells through regulating miR-374a/FGFR-2, which might provide new insight for breast cancer management. +genetics_knock down_promote 31207081 hsa-mir-133a Carcinoma, Hepatocellular Moreover, miR-133a inhibition significantly reversed the suppression effects of DLEU1 knockdown on HCC cells. +lncRNA target 31207072 hsa-mir-224 Squamous Cell Carcinoma of Head and Neck We concluded that miR-224 inhibited OSCC cell growth and invasion through regulating ADAM17 expression. +lncRNA target 31207033 hsa-mir-499a Glioma Hence, down-regulation of SCAMP1 remarkably reduced the expression level of LMX1A, indicating that LMX1A participated in miR-499a-5p-induced tumour-suppressive effects on glioma cells. +transcription factor target 31206669 hsa-mir-127 Obesity These findings identify miR-127 as an inhibitor of porcine adipogenesis, which may inform future strategies to reduce porcine fat deposition and treat human obesity. +genetics_overexpression_promote 31206665 hsa-mir-195 Pancreatic Carcinoma 5p and PD-L1 were altered with mimics, inhibitors, overexpression vectors or siRNAs in PC cells and cocultured CD8(+) T cells. +other 31206518 hsa-mir-5 Giardiasis RESULTS: All histologically proven duodenal biopsies of patients with Giardia infection were positive for Giardia miR5, with a mean threshold cycle (Ct) of 23.7, as well as for Giardia DNA qPCR (16S-like gene, mean Ct 26.3). CONCLUSION: Giardia miR5 testing in duodenal biopsies may be a new method for the diagnosis of giardiasis. +circRNA target 31206208 hsa-mir-204 Squamous Cell Carcinoma of Head and Neck 3p/APC2 axis represents a novel pathway involved in the pathogenesis of OSCC and may serve as a novel therapeutic target of OSCC. +transcription factor target 31206203 hsa-mir-137 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dual-luciferase report assay suggested that JARID1B was a direct target of miR-137 in ALL cell lines. +transcription factor target 31205587 hsa-mir-146a Sleep Apnea, Obstructive In conclusion, our results demonstrated that miR-146a-5p could attenuate viability and promote the apoptosis of H9c2 by targeting XIAP, thus aggravating the H9c2 cell injury induced by IH, which could enhance our understanding of the mechanisms for OSA-associated cardiac injury. +transcription factor target 31205587 hsa-mir-146a Heart Injuries In conclusion, our results demonstrated that miR-146a-5p could attenuate viability and promote the apoptosis of H9c2 by targeting XIAP, thus aggravating the H9c2 cell injury induced by IH, which could enhance our understanding of the mechanisms for OSA-associated cardiac injury. +other 31205555 hsa-mir-145 Ovarian Neoplasms To test discrimination of cancer from non-cancer, the area under the receiver operating characteristic curves determined for cancer antigen 125 (CA125), miR-145, miR-200c, miR-21, and miR-93 were 0.801 (p<0.001), 0.910 (p<0.001), 0.802 (p<0.001), 0.585 (p=0.303), and 0.755 (p=0.002), respectively. +circulation_biomarker_diagnosis_ns 31205555 hsa-mir-200c Ovarian Neoplasms Serum exosomal miRNA-145 and miRNA-200c as promising biomarkers for preoperative diagnosis of ovarian carcinomas. Conclusion: Expression of exosomal miR-93, miR-145 and miR-200c was significantly elevated in the serum of ovarian cancer patients. +circulation_biomarker_diagnosis_up 31205555 hsa-mir-21 Ovarian Neoplasms Exosomal RNA was extracted from the serum, and expression levels of seven miRNAs (miRNA-21, -93, -141, -145, -200a, -200b and -200c), which were reportedly dysregulated in serous ovarian cancer in previous studies, were quantified by real-time PCR, and compared between the four groups. +circulation_biomarker_diagnosis_up 31205555 hsa-mir-93 Ovarian Neoplasms Results: MiR-93, -145, and -200c, showed significantly higher expression in serum exosomes of the cancer group (HGSOC and non-HGSOC) than of the non-cancer group (benign and BOT; all p<0.05). +transcription factor target 31205515 hsa-mir-150 Colorectal Neoplasms Background: One of our previous studies have demonstrated that the cancer suppressor miR-150 regulated the progression of colorectal cancer (CRC) by down-regulating v-myb avian myeloblastosis viral oncogene homolog (c-Myb). +transcription factor target 31205511 hsa-mir-193a Carcinoma, Non-Small-Cell Lung Next, three NSCLC cell lines, A549 (p53 WT), H322 (p53 mutant), and H1299 (p53 null), were used to demonstrate the direct targeting of EGFR by miR-193a. Moreover, miR-193a inhibited NSCLC proliferation and invasion, and promotes NSCLC apoptosis by directly downregulating EGFR. +transcription factor target 31204938 hsa-mir-101 Lymphoma, Mantle-Cell The miR-101 can inhibit the cell proliferation and induce cell apoptosis of mantle cell lymphoma by targeting EZH2. +other 31204933 hsa-mir-34a Leukemia, Myeloid, Acute OBJECTIVE: To investigate the regulation of miR-34a on HDAC1 expression and its effect on the apoptosis of acute myeloid leukemia (AML) cells. +transcription factor target 31204929 hsa-mir-543 Leukemia OBJECTIVE: To investigate the regulatory effect of miR-543 on proliferation and apoptosis of human leukemia cell line K562 and its mechanism. CONCLUSION: miR-543 can target Wnt protein to inhibit the activity of Wnt signaling pathway, thereby inhibiting the proliferation of leukemia cells and increasing the level of apoptosis. +transcription factor target 31204609 hsa-mir-149 Prostatic Neoplasms Particularly, miRNA-149 is upregulated in a variety of cancers such as prostate cancer and is therefore a potential target for drug development. +genetics_overexpression_suppress 31204563 hsa-mir-520g Multiple Myeloma Conclusion: Our findings demonstrated that combined overexpression of miR-520g and miR-520h overcomes bortezomib resistance in MM through inhibition of DNA repair, offering a promising therapeutic target for MM treatment. +genetics_overexpression_suppress 31204563 hsa-mir-520h Multiple Myeloma Conclusion: Our findings demonstrated that combined overexpression of miR-520g and miR-520h overcomes bortezomib resistance in MM through inhibition of DNA repair, offering a promising therapeutic target for MM treatment. +transcription factor target 31204513 hsa-mir-204 Uterine Cervical Neoplasms Conclusions: miR-204 could inhibit proliferation and autophagy and induce apoptosis of cervical cancer cells by targeting ATF2, representing promising target for cervical cancer treatment. +other 31204374 hsa-mir-199b Familial Primary Pulmonary Hypertension 5p/miRNA-199b-5p-HIF1A-lncRNA CTEPHA1 are related to the development of CTEPH. +other 31204374 hsa-mir-338 Familial Primary Pulmonary Hypertension 5p/miRNA-199b-5p-HIF1A-lncRNA CTEPHA1 are related to the development of CTEPH. +other 31204374 hsa-mir-149 Familial Primary Pulmonary Hypertension 5p/miRNA-199b-5p-HIF1A-lncRNA CTEPHA1 are related to the development of CTEPH. +circulation_biomarker_diagnosis_up 31204352 hsa-mir-126 Atherosclerosis 5p was measured in peripheral blood of AS patients and healthy control. +lncRNA target 31204163 hsa-mir-21 Fibrosis INTRODUCTION AND OBJECTIVES: Transforming growth factor beta1 (TGFbeta1) and dysregulated microRNA-21 (miR-21) expression is associated with TGFbeta/Smad signaling pathway activation and fibrosis. +other 31203154 hsa-mir-216 Pre-Eclampsia Therefore, the Met/H19/miR-148a-5p/P28 and Met/H19/miR3p/EBI3 signaling pathways were implicated in the pathogenesis of PE. +other 31203154 hsa-mir-148a Pre-Eclampsia Therefore, the Met/H19/miR-148a-5p/P28 and Met/H19/miR3p/EBI3 signaling pathways were implicated in the pathogenesis of PE. +other 31203154 hsa-mir-148 Pre-Eclampsia Therefore, the Met/H19/miR-148a-5p/P28 and Met/H19/miR3p/EBI3 signaling pathways were implicated in the pathogenesis of PE. +transcription factor target 31202813 hsa-mir-25 Carcinoma, Renal Cell We further postulate that the therapeutic targeting of miR-25 can be useful for preventing the metastatic progression of ccRCC associated with IMPA2 downregulation. +genetics_overexpression_promote 31201869 hsa-mir-613 Hepatitis B, Chronic 3p overexpression reversed these changes in vitro and in vivo. +genetics_knock down_promote 31201812 hsa-mir-449a Endometrial Neoplasms Conversely, loss of miR-449a in EC cancer cells facilitated all these cellular activities. +circRNA target 31200957 hsa-mir-1244 Osteosarcoma In mechanism, circSAMD4A could sponge miR-1244 in OS cells. In conclusion, circSAMD4A/miR-1244/MDM2 regulatory loop might be a promising therapeutic target for OS treatment. +circulation_biomarker_diagnosis_ns 31200481 hsa-mir-206 Hyperlipidemias Ten circulating miRNAs were finally validated as responsive to postprandial lipemia, including miR +circulation_biomarker_diagnosis_ns 31200481 hsa-mir-543 Hyperlipidemias Ten circulating miRNAs were finally validated as responsive to postprandial lipemia, including miR +circulation_biomarker_diagnosis_ns 31200481 hsa-mir-40 Hyperlipidemias Ten circulating miRNAs were finally validated as responsive to postprandial lipemia, including miR +circulation_biomarker_diagnosis_ns 31200481 hsa-mir-125a Hyperlipidemias Ten circulating miRNAs were finally validated as responsive to postprandial lipemia, including miR +circulation_biomarker_diagnosis_ns 31200481 hsa-mir-409 Hyperlipidemias Ten circulating miRNAs were finally validated as responsive to postprandial lipemia, including miR +circulation_biomarker_diagnosis_ns 31200481 hsa-mir-1941 Hyperlipidemias Ten circulating miRNAs were finally validated as responsive to postprandial lipemia, including miR +circulation_biomarker_diagnosis_ns 31200481 hsa-mir-468 Hyperlipidemias Ten circulating miRNAs were finally validated as responsive to postprandial lipemia, including miR +circulation_biomarker_diagnosis_ns 31200481 hsa-mir-10a Hyperlipidemias Ten circulating miRNAs were finally validated as responsive to postprandial lipemia, including miR +circulation_biomarker_diagnosis_ns 31200481 hsa-mir-27b Hyperlipidemias Ten circulating miRNAs were finally validated as responsive to postprandial lipemia, including miR +transcription factor target 31200131 hsa-mir-4306 Esophageal Squamous Cell Carcinoma Through the miRNA-mRNA-transcription factor (TF) network, hsa-miR +transcription factor target 31200131 hsa-mir-18 Esophageal Squamous Cell Carcinoma Through the miRNA-mRNA-transcription factor (TF) network, hsa-miR +transcription factor target 31200131 hsa-mir-128 Esophageal Squamous Cell Carcinoma Through the miRNA-mRNA-transcription factor (TF) network, hsa-miR +transcription factor target 31200131 hsa-mir-376a Esophageal Squamous Cell Carcinoma Through the miRNA-mRNA-transcription factor (TF) network, hsa-miR +other 31200102 hsa-mir-137 Mental Disorders miR-137 is a highly conserved microRNA (miRNA) that is associated with the control of brain function and the etiology of psychiatric disorders including schizophrenia and bipolar disorder. Defective regulation of miR-137 is associated with psychiatric disorders that include schizophrenia and bipolar disorder. +other 31200102 hsa-mir-137 Bipolar Disorder miR-137 is a highly conserved microRNA (miRNA) that is associated with the control of brain function and the etiology of psychiatric disorders including schizophrenia and bipolar disorder. Defective regulation of miR-137 is associated with psychiatric disorders that include schizophrenia and bipolar disorder. +other 31200102 hsa-mir-137 Schizophrenia miR-137 is a highly conserved microRNA (miRNA) that is associated with the control of brain function and the etiology of psychiatric disorders including schizophrenia and bipolar disorder. Defective regulation of miR-137 is associated with psychiatric disorders that include schizophrenia and bipolar disorder. +other 31200102 hsa-mir-234 Neuromuscular Junction Diseases Further analysis revealed that mir-234 controls neuropeptide levels, therefore positing a cause of NMJ dysfunction. +lncRNA target 31199884 hsa-mir-19a Colorectal Neoplasms In conclusion, miR-19a inhibition suppresses the viability, migration, and invasiveness of CRC cells, and suppresses the migration and tube-formation abilities of HLECs, and further, inhibits tumor growth and lymphatic tube formation in vivo via targeting THBS1. +genetics_overexpression_promote 31199813 hsa-mir-509 Melanoma We overexpressed miR +transcription factor target 31199581 hsa-mir-34b Carcinoma, Non-Small-Cell Lung In conclusion, our findings reveal that miR-34b-3p might function as a tumour suppressor in NSCLC by targeting CDK4 and that miR-34b-3p may, therefore, serve as a biomarker for the diagnosis and treatment of NSCLC. +genetics_knock down_promote 31199066 hsa-mir-140 Tuberculosis TRAF6 overexpression increased the pro-inflammatory cytokines levels and partially restored the suppressive effects of miR-140 overexpression on pro-inflammatory cytokines levels in THP-1 and U937 cells with M tb infection. +genetics_knock down_promote 31199052 hsa-mir-551b Cholangiocarcinoma Gain- and loss-of-function experiments found that miR-551b-3p inhibited the proliferation, G1-S phase transition and induced apoptosis of CCA cells. +other 31199049 hsa-mir-140 Urinary Bladder Neoplasms 5p, and aberrant expression of PLOD1 was observed in BC clinical specimens. +lncRNA target 31199037 hsa-mir-375 Stomach Neoplasms RESULTS: Circ-SERPINE2 and YWHAZ were upregulated, and miR-375 was downregulated in GC tissues and cells. Circ-SERPINE2/miR-375/YWHAZ axis might provide a novel therapeutic target of GC. +other 31198977 hsa-mir-1277 Osteoarthritis In conclusion, the present study suggests that XIST promotes MMP13 and ADAMTS5 expression, indicating ECM degradation, by functioning as a ceRNA of miR12775p in OA. +transcription factor target 31198976 hsa-mir-145 Urinary Bladder Neoplasms Furthermore, the combination of celecoxib with miR145 mimics demonstrated an additive migration and invasioninhibitory effect in BC cell lines. +other 31198949 hsa-mir-122 Chemical and Drug Induced Liver Injury 3p demonstrated a much more significant induction in patients with hepatocellular DILI, thus revealing better specificity for hepatocellular damage. +genetics_GWAS 31198450 hsa-mir-605 Schizophrenia CONCLUSION: No significant difference existed between schizophrenic patients and controls in SNP (rs2043556 and rs4909237) in the precursor region of hsa-miR-605 and pre-hsa-miR-499a/pre-hsa-miR-499b. +genetics_overexpression_promote 31198063 hsa-mir-1285 Prostatic Neoplasms The expression of Smad4, a well-known suppressive gene in PCa, can be increased by overexpression of hsa_circ_0001206 and this effect could be partly reversed by co-transfection of miR5p mimic. +other 31198060 hsa-mir-377 Sjogren's Syndrome Conclusion: Mirt2 was elevated in IFN-gamma-treated SGECs and then up-regulated miR-377 in response to inflammatory lesions. +other 31197641 hsa-mir-29a Alzheimer Disease Meanwhile, klotho induced miR-29a expression in the PBMCs of HCs, while miR-29a expression was induced in the AD group by klotho and linagliptin. +lncRNA target 31197610 hsa-mir-612 Neurofibromatosis 1 Finally, rescue and in vivo assays affirmed that miR-612 targeted FAIM2 to regulate cellular activities of NF1. +epigenetics 31197517 hsa-mir-124 Esophageal Neoplasms In conclusion, miR-124 may function as a tumor suppressive miRNA, and hypermethylation-mediated inactivation of miR-124 may be useful for a poor prognostic marker for ESCC patients. +epigenetics 31197517 hsa-mir-124-1 Esophageal Neoplasms In conclusion, miR-124 may function as a tumor suppressive miRNA, and hypermethylation-mediated inactivation of miR-124 may be useful for a poor prognostic marker for ESCC patients. +other 31197461 hsa-mir-455 Chordoma Immunopositivity for Gal9 was associated with tumor invasion (p = 0.019), Karnofsky performance status (KPS) score (p = 0.017), and total TIL count (p < 0.001); downregulation of miR5p was correlated with tumor invasion (p = 0.017) and poor prognosis; and the T-cell immunoglobulin and mucin-domain 3 (TIM3)(+) TIL count was associated with chordoma invasion (p = 0.010) and KPS score (p = 0.037). +other 31197441 hsa-mir-100 Ovarian Neoplasms MiR-100 was negatively correlated with HAGLROS (r = 0.167, P = 0.001) and significantly downregulated in ovarian cancer. +other 31196742 hsa-mir-877 Glioblastoma 5p to regulate SUZ12 expression. +other 31196713 hsa-mir-205 Nasopharyngeal Carcinoma Since microRNA-205 (miR-205) is predictive biomarkers for radiation-resistant of nasopharyngeal carcinoma, monitoring of the dynamic variation of miR-205 is of great interest for developing a personalized strategy for the treatment of NPC. +lncRNA target 31196629 hsa-mir-125a Acute Lung Injury Further studies suggest that AGM decreased the upregulated expression of lncRNA gadd7 caused by hyperoxia and due to the presence of the competitive binding of lncRNA gadd7 and MFN1 to miR-125a, AGM indirectly decreased MFN1 protein expression to inhibit the cells apoptosis. +lncRNA target 31196629 hsa-mir-125a Hyperoxia-Induced Lung Injury Further studies suggest that AGM decreased the upregulated expression of lncRNA gadd7 caused by hyperoxia and due to the presence of the competitive binding of lncRNA gadd7 and MFN1 to miR-125a, AGM indirectly decreased MFN1 protein expression to inhibit the cells apoptosis. +lncRNA target 31196157 hsa-mir-20a Breast Neoplasms CONCLUSION: Collectively, these data indicated that PTENP1/miR-20a/PTEN axis involved in the malignant behaviors of BC cells, illuminating the possible mechanism mediated by PTEN via PI3K/Akt pathway. +lncRNA target 31196036 hsa-let-7i Urinary Bladder Neoplasms CONCLUSIONS: Up-regulation of let-7i suppressed proliferation and migration of the human bladder cancer cell lines T24 and 5637 by targeting HMGA1. +transcription factor target 31196010 hsa-mir-890 Triple Negative Breast Neoplasms RESULTS: The upregulation of miR-890 inhibited cell proliferation and invasion, induced apoptosis in MDA-MB-231 and HCC-70 TNBC cells by negatively regulating its target gene, CD147, and the upregulation of CD147 rescued the inhibitory effects of miR-890. CONCLUSION: The downregulation of miR-890 is the potential cause of high CD147 expression in TNBC, which can promote the malignant transformation of TNBC. +lncRNA target 31195981 hsa-mir-122 Non-alcoholic Fatty Liver Disease CONCLUSION: The inhibition of miR-122 protects hepatocytes from lipid metabolic disorders such as NAFLD and suppresses lipogenesis via elevating Sirt1 and activating the AMPK pathway. +lncRNA target 31195398 hsa-mir-130b Carcinoma, Renal Cell yl-2,5-diphenyltetrazolium bromide (MTT) assay in RCC cell lines transfected with miR-130b inhibitor or miR-130b mimics. +other 31195367 hsa-mir-181a Diabetic Nephropathies These results provide new insights into the regulation between MEG3 and the miR-181a/Egr-1/TLR4 signaling pathway during DN progression. +other 31195093 hsa-mir-145 Neoplasm Metastasis Thus, the aim of this study is to evaluate the expression level of miR3p which is a shared potential biomarker identified by meta-analysis of breast, prostate and lung cancer data sets. +lncRNA target 31194976 hsa-mir-200c Ovarian Neoplasms Therapies involving miR-200c or targeting CD44 should help treat ovarian cancer with high Gab2 expression. +lncRNA target 31194941 hsa-mir-146a Acne Vulgaris Increased expressions of miR-146a and toll-like receptor (TLR) 2 were detected in acne lesions. acnes induces miR-146a, which can downregulate the production of IL-6, -8, and TNF-alpha in acne inflammation by inhibiting the TLR2/IRAK1/TRAF6/NF-kappaB and MAPK pathways. +lncRNA target 31194576 hsa-mir-200c Wilms Tumor miR-200c-3p inhibited the proliferative, migratory, and invasive capacities of nephroblastoma cells by targeting FRS2. +lncRNA target 31194025 hsa-mir-421 Stomach Neoplasms In this study, we evaluated the expression of important genes involved in the recognition of DNA damage (ATM, ATR, and H2AX) and ROS-induced damage repair (APE1) and the expression of some miRNAs (miR-15a, miR-21, miR-24, miR-421 and miR-605) that target genes involved in the DNA damage response (DDR) in 31 fresh tissues of gastric cancer. +lncRNA target 31192947 hsa-mir-3133 Carcinoma, Renal Cell MiR-3133 might be an independent prognostic biomarker in ccRCC patients (HR = 2.802, 95% CI = 1.391-5.646, P = .004).MiR-3133 is downregulated, and plays inhibitory roles in aggressive progression of ccRCC. +circulation_biomarker_diagnosis_ns 31191754 hsa-mir-499 Myocardial Infarction Conclusion The results showed that circulating microRNA-499 is a reliable biomarker for diagnosing AMI patients. +other 31191744 hsa-mir-497 Carcinoma The aim of this study was to investigate the prognostic role of miR-497 in various carcinomas. No significant association was found between miR-497 expression and DFS/RFS in various carcinomas (HR = 1.17, 95% CI: 0.53-2.57). +other 31191687 hsa-mir-1290 Autism Spectrum Disorder "Here, we show that miR-1290 is significantly downregulated during neuronal differentiation in reprogrammed induced pluripotent stem cell- (iPSC-) derived neurons obtained from idiopathic autism spectrum disorder (ASD) patients. Supplementing ASD patient-derived neural stem cells (NSCs) with conditioned media from differentiated control-NSCs spiked with ""artificial EVs"" containing synthetic miR-1290 oligonucleotides significantly rescued differentiation deficits in ASD cell lines." +other 31191653 hsa-let-7b Breast Neoplasms Moreover, we previously reported an association between DRC levels and the expression of the microRNA (miRNA) let-7b in BC patients. +transcription factor target 31191607 hsa-mir-200a Fatty Liver 5p, through directly targeting 3'-UTR of CYP3A4, contribute to the development of FFA-induced steatosis. +transcription factor target 31191607 hsa-mir-150 Fatty Liver 5p, through directly targeting 3'-UTR of CYP3A4, contribute to the development of FFA-induced steatosis. +circulation_biomarker_diagnosis_ns 31191602 hsa-mir-191 Hemolysis We also propose a new reference microRNA, miR5p, which is relatively stable in serum samples with mild hemolysis. +circulation_biomarker_diagnosis_ns 31191602 hsa-mir-371a Testicular Germ Cell Tumor For testicular germ cell tumors (GCT), circulating microRNAs 371a-3p and 372-3p in serum and plasma have been proposed as biomarkers for diagnostic and disease monitoring purposes. +circulation_biomarker_diagnosis_ns 31191602 hsa-mir-372 Testicular Germ Cell Tumor For testicular germ cell tumors (GCT), circulating microRNAs 371a-3p and 372-3p in serum and plasma have been proposed as biomarkers for diagnostic and disease monitoring purposes. +other 31191492 hsa-mir-140 Tuberculosis 3p, and hsa-miR-193b-5p). +other 31191492 hsa-mir-370 Tuberculosis 3p, and hsa-miR-193b-5p). +other 31191492 hsa-mir-1246 Tuberculosis 3p, and hsa-miR-193b-5p). +other 31191492 hsa-let-7d Tuberculosis 3p, and hsa-miR-193b-5p). +other 31191492 hsa-let-7e Tuberculosis 3p, and hsa-miR-193b-5p). +other 31191492 hsa-mir-450a Tuberculosis 3p, and hsa-miR-193b-5p). +other 31191492 hsa-mir-2110 Tuberculosis 3p, and hsa-miR-193b-5p). +other 31191492 hsa-mir-28 Tuberculosis 3p, and hsa-miR-193b-5p). +other 31191492 hsa-mir-193b Tuberculosis 3p, and hsa-miR-193b-5p). +circulation_biomarker_prognosis_ns 31191331 hsa-mir-155 Depression Altogether, these present findings demonstrate that Tai Chi improves CHD prognosis, by affecting serum levels of the miR-24 and miR-155. +circulation_biomarker_prognosis_ns 31191331 hsa-mir-24 Depression Altogether, these present findings demonstrate that Tai Chi improves CHD prognosis, by affecting serum levels of the miR-24 and miR-155. +lncRNA target 31190897 hsa-mir-1323 Carcinoma, Hepatocellular Secondly, we found that TP53INP1 was a direct target of miR-1323 and could reverse the effects of miR-1323 on proliferation, invasion and apoptosis of HCC cells. +transcription factor target 31190893 hsa-mir-1284 Stomach Neoplasms MiR-1284 inhibited invasion, migration, and proliferation of GC cells. +lncRNA target 31190882 hsa-mir-449a Carcinoma, Non-Small-Cell Lung Conclusion: Our experiments demonstrated that miRNA-449a acted as a tumor suppressor gene through inhibiting the expression of ADAM10 in NSCLC. +lncRNA target 31190862 hsa-mir-106b Carcinoma, Renal Cell Conclusion: The study suggested that miR-106b regulated RCC progression through MAPK signaling pathway partly by targeting Capicua, which might provide valuable evidence for therapeutic target development of RCC. +lncRNA target 31190856 hsa-mir-124 Urinary Bladder Neoplasms Conclusion: MicroRNA-124 suppressed the proliferation of CRC cells by directly targeting CDK4, which provides a target for improving the therapeutic effect of BC. +epigenetics 31190579 hsa-mir-335 Multiple Myeloma Moreover, aberrant promoter hyper-methylation is critical for miR-335 silencing in MM. +lncRNA target 31190561 hsa-mir-124 Inflammation LINC00305-caused miR-124 silence compromises ATDC5 cell viability and ultimately results in inflammatory insults by activating Notch/NF-kappaB pathway. +lncRNA target 31190447 hsa-mir-623 Carcinoma, Hepatocellular Collectively, our data suggested that miR-623 suppressed the progression of HCC by regulating the PI3K/Akt, Wnt/beta-catenin, and ERK/JNK pathways by targeting XRCC5 in HCC in vitro, indicating that miR-623 may be a target for the therapy of HCC. +circulation_biomarker_prognosis_ns 31190421 hsa-mir-129 Carcinoma, Hepatocellular Serum LNC NEAT and MiR5p could be used as potential biomarkers for HCC cancer diagnosis and prognosis. +genetics_overexpression_promote 31190375 hsa-mir-5590 Triple Negative Breast Neoplasms 3p overexpression-mediated inhibitive effect on TNBC progression. +genetics_overexpression_promote 31190356 hsa-mir-522 Carcinoma, Non-Small-Cell Lung Overexpression of miR +genetics_overexpression_suppress 31190355 hsa-mir-22 Small Cell Lung Carcinoma miR-22 overexpression could significantly inhibit the cell migration of SCLC cells, and miR-22 had a negative regulatory effect on WRNIP1 mRNA and protein levels. +other 31190353 hsa-mir-29a Carcinoma, Hepatocellular Of note, SEVO restored miR-29a which was downregulated in HCC tissues and cells. In conclusion, SEVO restored the expression of miR-29a, which posttranscriptionally downregulated Dnmt3a, and then exhibited an antitumor property in HCC cells. +lncRNA target 31190351 hsa-mir-522 Osteosarcoma Finally, the results of mechanism experiments elucidated that miR-522 stimulated TGF-beta/Smad pathway to induce the development of OS via targeting PPM1A, which exposed that miR-522 may become a promising curative target for OS patients. +lncRNA target 31190349 hsa-mir-194 Chronic Urticaria In this present study, we aim to investigate whether miR-194 has an effect on attenuating inflammatory response and human dermal microvascular endothelial cells (HDMECs) permeability of CIU mast cells through TGF-beta/SMAD pathway by binding to thrombospondin 1 (THBS1). Our study provides evidence that miR-194 negatively modulates THBS1 and inhibits the activation of TGF-beta/SMAD pathway, thereby alleviating the inflammatory response and HDMECs permeability of mast cells in CIU. +genetics_knock down_promote 31190335 hsa-mir-4429 Uterine Cervical Neoplasms Gain- and loss-of-function assays validated that miR-4429 sensitized CC cells to irradiation. +transcription factor target 31190333 hsa-mir-218 Carcinoma, Non-Small-Cell Lung CONCLUSION Nicotine promotes proliferation of NSCLC cells through regulating the miR-218/CDK6 axis, which may be a potential therapeutic target for lung cancer. +exosome 31190315 hsa-mir-124 Brain Injuries, Traumatic Thus, treatment with microglial exosomes enriched with miR +circulation_biomarker_diagnosis_up 31189969 hsa-mir-25 Cystic Fibrosis Recently, we found serum miRNA3p (miR-25) levels were upregulated in children with Cystic Fibrosis (CF) without liver disease, compared to children with CF-associated liver disease and healthy individuals. +circulation_biomarker_diagnosis_up 31189969 hsa-mir-25 Liver Diseases Recently, we found serum miRNA3p (miR-25) levels were upregulated in children with Cystic Fibrosis (CF) without liver disease, compared to children with CF-associated liver disease and healthy individuals. +lncRNA target 31189920 hsa-mir-194 Glioma Next, through online databases, a luciferase reporter assay and an RNA pull-down assay, we confirmed that SNHG1 functions as a sponge for miR-194, which acts as a suppressor in glioma. Taken together, our study shows that SNHG1 promotes glioma progression by competitively binding to miR-194 to regulate PHLDA1 expression, which may provide a novel therapeutic strategy for glioma. +circulation_biomarker_diagnosis_ns 31189875 hsa-mir-21 Shock, Septic In addition, by analyzing published miRNA expression profiles in the Gene Expression Omnibus database, we found that the miR-21 levels in peripheral blood from patients with septic shock were elevated. +circulation_biomarker_diagnosis_ns 31189875 hsa-mir-21 Syphilis In addition, by analyzing published miRNA expression profiles in the Gene Expression Omnibus database, we found that the miR-21 levels in peripheral blood from patients with septic shock were elevated. +other 31189706 hsa-mir-155 Lymphoma Marek's Disease Virus-Encoded MicroRNA 155 Ortholog Critical for the Induction of Lymphomas Is Not Essential for the Proliferation of Transformed Cell Lines. Among the limited set of genes associated with MD oncogenicity, MDV-miR-M4, a highly expressed viral ortholog of the oncogenic miR-155, has received extensive attention due to its direct role in the induction of lymphomas. +lncRNA target 31189298 hsa-mir-16 Neuralgia Furthermore, inhibition of miR-15a and miR-16 downregulated the expression of interleukin-1beta and tumor-necrosis factor-alphain the spinal cord of CCI rats. +lncRNA target 31189298 hsa-mir-15a Neuralgia Furthermore, inhibition of miR-15a and miR-16 downregulated the expression of interleukin-1beta and tumor-necrosis factor-alphain the spinal cord of CCI rats. +other 31188886 hsa-mir-125a Retinal Diseases Whereas in choroid, miR-let-7f-5p, miR-126a-5p and miR-101a-3p were downregulated by (>81%), and miR-125a-5p, let-7e-5p and let-7g-5p were upregulated by (>570%) during NV. +other 31188886 hsa-let-7e Retinal Diseases Whereas in choroid, miR-let-7f-5p, miR-126a-5p and miR-101a-3p were downregulated by (>81%), and miR-125a-5p, let-7e-5p and let-7g-5p were upregulated by (>570%) during NV. +other 31188886 hsa-mir-199a Retinal Diseases During OIR-induced vessel degeneration phase, miR-199a-3p, -199a-5p, -1b, -126a-3p displayed a robust decreased expression (> 85%) in the retina. +other 31188886 hsa-mir-101a Retinal Diseases Whereas in choroid, miR-let-7f-5p, miR-126a-5p and miR-101a-3p were downregulated by (>81%), and miR-125a-5p, let-7e-5p and let-7g-5p were upregulated by (>570%) during NV. +other 31188886 hsa-let-7g Retinal Diseases Whereas in choroid, miR-let-7f-5p, miR-126a-5p and miR-101a-3p were downregulated by (>81%), and miR-125a-5p, let-7e-5p and let-7g-5p were upregulated by (>570%) during NV. +other 31188886 hsa-mir-126a Retinal Diseases Whereas in choroid, miR-let-7f-5p, miR-126a-5p and miR-101a-3p were downregulated by (>81%), and miR-125a-5p, let-7e-5p and let-7g-5p were upregulated by (>570%) during NV. +other 31188886 hsa-let-7f Retinal Diseases Whereas in choroid, miR-let-7f-5p, miR-126a-5p and miR-101a-3p were downregulated by (>81%), and miR-125a-5p, let-7e-5p and let-7g-5p were upregulated by (>570%) during NV. +lncRNA target 31188543 hsa-let-7a Prostatic Neoplasms MiR-let-7a-5p could target both lncRNA LOXL1-AS1 and EGFR to affect PCa progression. +genetics_knock down_suppress 31188485 hsa-mir-451 Myocardial Reperfusion Injury Propofol pretreatment significantly increased miRNA-451 expression, decreased HMGB1 expression, reduced infarct size, and I/R-induced cardiomyocyte apoptosis in rat hearts undergoing I/R injuries. Knockdown of miRNA-451 48 hr before I/R injury was found to increase HMGB1 expression, infarct size, and I/R-induced cardiomyocyte apoptosis in rat hearts in the presence of propofol pretreatment. +lncRNA target 31188482 hsa-mir-377 Stomach Neoplasms In conclusion, LINC00339 promotes gastric cancer progression by elevating DCP1A expression via inhibiting miR3p. +lncRNA target 31187677 hsa-mir-29b Endometrial Neoplasms RESULTS: miR-29b inhibited proliferation and decreased migration and invasion of endometrial cancer cells. +other 31187646 hsa-mir-155 Reperfusion Injury, Cerebral Ischemia Our findings showed that the lncRNA Oprm1/miR-155/GATA3 axis plays an important role in cerebral I/R injury. +lncRNA target 31187495 hsa-mir-139 Glioblastoma 5p in GBM and eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) was found to be a downstream target of miR +genetics_overexpression_promote 31187488 hsa-mir-378a Squamous Cell Carcinoma of Head and Neck The effect of miR-378a overexpression on OSCC cells was similar to those of circRNA_100290 silence. +other 31187432 hsa-mir-182 Breast Neoplasms Then, three BC leading miRNAs (hsa-miR-149, hsa-miR-182, and hsa-miR-383) were also introduced from merging several established ceRNAs networks. +other 31187432 hsa-mir-383 Breast Neoplasms Then, three BC leading miRNAs (hsa-miR-149, hsa-miR-182, and hsa-miR-383) were also introduced from merging several established ceRNAs networks. +other 31187432 hsa-mir-149 Breast Neoplasms Then, three BC leading miRNAs (hsa-miR-149, hsa-miR-182, and hsa-miR-383) were also introduced from merging several established ceRNAs networks. +genetics_overexpression_promote 31187349 hsa-mir-200a Lung Neoplasms Furthermore, H19 overexpression inhibited miR-200a function and thereby upregulated miR-200a target genes, ZEB1 and ZEB2.H19 sponged and inhibited miR-200a to de-repress expression of ZEB1 and ZEB2, and thereby enhanced lung cancer proliferation and metastasis. +genetics_GWAS 31186809 hsa-mir-500 Leukemia, Myeloid, Acute miR-500(low) patients were associated with low-risk AML (P=0.003) and core-binding factor subunit b-myosin heavy chain 11 translocation mutation (P=0.021). +other 31186807 hsa-mir-135b Nasopharyngeal Carcinoma In addition, miR-18a [Hazard ratio (HR), 3.405; 95% confidence interval (CI), 1.334-8.693] and miR-135b (HR, 2.482; 95% CI, 1.014-6.076) may serve prognostic roles for patients with NPC. In addition, miR-18a and miR-135b may present useful prognostic markers for patients with NPC. +other 31186807 hsa-mir-18a Nasopharyngeal Carcinoma In addition, miR-18a [Hazard ratio (HR), 3.405; 95% confidence interval (CI), 1.334-8.693] and miR-135b (HR, 2.482; 95% CI, 1.014-6.076) may serve prognostic roles for patients with NPC. In addition, miR-18a and miR-135b may present useful prognostic markers for patients with NPC. +other 31186806 hsa-mir-425 Leukemia, Myeloid, Acute The aim of the present study was to investigate whether the expression levels of microRNA-425 (miR-425) were associated with the prognosis of acute myeloid leukemia (AML) in patients treated with chemotherapy or allogeneic hematopoietic stem cell transplantation (allo-HSCT). In conclusion, the current data indicated that miR-425 is an independent favorable prognostic factor for younger AML patients undergoing chemotherapy, and its use may facilitate clinical decision-making in selecting treatment for AML patients. +transcription factor target 31186804 hsa-mir-129 Lung Neoplasms 5p was identified to target HMGB1 and miR +circulation_biomarker_diagnosis_ns 31186794 hsa-mir-153 Uterine Cervical Neoplasms In conclusion, the level of miR-153 in peripheral blood may be utilized as an effective biomarker for the early detection of cervical cancer, thus decreasing the requirement for invasive cervical biopsies. +circulation_biomarker_diagnosis_ns 31186794 hsa-mir-152 Cervical Intraepithelial Neoplasia Furthermore, miR-152 levels in peripheral blood were higher in patients with high-grade CIN compared with those with low-grade CIN. +circulation_biomarker_diagnosis_ns 31186794 hsa-mir-152 Uterine Cervical Neoplasms Furthermore, miR-152 levels in peripheral blood were higher in patients with high-grade CIN compared with those with low-grade CIN. +circulation_biomarker_diagnosis_ns 31186794 hsa-mir-153 Cervical Intraepithelial Neoplasia In conclusion, the level of miR-153 in peripheral blood may be utilized as an effective biomarker for the early detection of cervical cancer, thus decreasing the requirement for invasive cervical biopsies. +genetics_overexpression_promote 31186793 hsa-mir-144 Stomach Neoplasms Furthermore, overexpression of miR-144 suppressed HGC-27 cell proliferation, migration and invasion. +circulation_biomarker_diagnosis_ns 31186782 hsa-mir-93 Ovarian Neoplasms 5p were significantly increased in patients with ovarian cancer compared with those in the healthy controls, while the plasma expression levels of hsa-miR +circulation_biomarker_diagnosis_ns 31186782 hsa-mir-122 Ovarian Neoplasms 5p were significantly increased in patients with ovarian cancer compared with those in the healthy controls, while the plasma expression levels of hsa-miR +circulation_biomarker_diagnosis_ns 31186782 hsa-mir-99b Ovarian Neoplasms 5p were significantly increased in patients with ovarian cancer compared with those in the healthy controls, while the plasma expression levels of hsa-miR +other 31186777 hsa-mir-34b Carcinoma, Non-Small-Cell Lung miR-34b and p53 may serve as important tumor markers for NSCLC. +genetics_knock down_promote 31186763 hsa-mir-10a Squamous Cell Carcinoma of Head and Neck Furthermore, GLUT1 overexpression promoted glucose uptake; however, no significant increase in the expression level of miRNA-10a in OSCC cells was detected. +other 31186760 hsa-mir-1271 Stomach Neoplasms The high expression of miR-1271 was better than that of patients with the low expression in young and elderly gastric cancer. +lncRNA target 31186737 hsa-mir-136 Osteosarcoma Together, the results suggested that miR-136 functions as a tumor suppressor gene to regulate proliferation, migration and invasion of OS cells. +lncRNA target 31186736 hsa-mir-196a Esophageal Squamous Cell Carcinoma In conclusion, the miR-196a/ANXA1 axis may represent a potential therapeutic target in ESCC. +lncRNA target 31186724 hsa-mir-126 Breast Neoplasms Thus, miR-124 and miR-126 may be involved in the occurrence, development, invasion and metastasis of BC, and both can be used as targeted biological indexes for treatment of BC. +lncRNA target 31186724 hsa-mir-124 Breast Neoplasms Thus, miR-124 and miR-126 may be involved in the occurrence, development, invasion and metastasis of BC, and both can be used as targeted biological indexes for treatment of BC. +lncRNA target 31186710 hsa-mir-503 Carcinoma, Non-Small-Cell Lung The downregulation of lncRNA MIR503HG induced by XAV939 may serve an important role in NSCLC suppression via sponging miR-1273c and regulating SOX4 expression. +tissue_expression_ns 31186695 hsa-mir-146b Hashimoto Disease The expression level of microRNA (miRNA)-146b in patients with thyroid carcinoma (TC) in combination with Hashimoto's thyroditis (HT) was evaluated to analyze the clinical significance. Correlation between the miRNA-146b-5p levels and the clinicopathological characteristics of patients with combined TC and HT were evaluated. High expression of miRNA-146b-5p was found in the cancer tissues of patients with combined TC and HT. +tissue_expression_ns 31186695 hsa-mir-146b Thyroid Neoplasms The expression level of microRNA (miRNA)-146b in patients with thyroid carcinoma (TC) in combination with Hashimoto's thyroditis (HT) was evaluated to analyze the clinical significance. Correlation between the miRNA-146b-5p levels and the clinicopathological characteristics of patients with combined TC and HT were evaluated. High expression of miRNA-146b-5p was found in the cancer tissues of patients with combined TC and HT. +lncRNA target 31186404 hsa-mir-18a Stomach Neoplasms We demonstrated that MIR17HG-derived miR-18a and miR-19a coordinately mediate gastric cancer cell metastasis by directly inhibiting SMAD2 expression and upregulating Wnt/beta-catenin signalling. We conclude that IRF-1 inhibits gastric cancer metastasis by downregulating MIR17HG-miR-18a/miR-19a axis expression and attenuating Wnt/beta-catenin signalling. +lncRNA target 31186404 hsa-mir-19a Stomach Neoplasms We demonstrated that MIR17HG-derived miR-18a and miR-19a coordinately mediate gastric cancer cell metastasis by directly inhibiting SMAD2 expression and upregulating Wnt/beta-catenin signalling. We conclude that IRF-1 inhibits gastric cancer metastasis by downregulating MIR17HG-miR-18a/miR-19a axis expression and attenuating Wnt/beta-catenin signalling. +other 31186261 hsa-mir-210 Breast Neoplasms high ROR-PT group. +lncRNA target 31186161 hsa-mir-145 Carcinoma, Hepatocellular GOLM1 and miR-145 were inversely correlated in human HCC tissues. We suggest that mTOR/miR-145/GOLM1 signaling pathway should be targeted for HCC treatment. +lncRNA target 31186064 hsa-mir-590 Glioma 3p-induced tumor-suppressive activity on glioma cells. +other 31185986 hsa-mir-526b Breast Neoplasms upregulated microRNAs, miR-526b and miR-655, both found to be oncogenic and SLC-promoting. +other 31185986 hsa-mir-655 Breast Neoplasms upregulated microRNAs, miR-526b and miR-655, both found to be oncogenic and SLC-promoting. +lncRNA target 31185507 hsa-mir-181 Nervous System Diseases Both DMOG and Ac-LETD-CHO increased HIF-1alpha expression paralleled with the suppression of miR +lncRNA target 31185507 hsa-mir-181 Hyperglycemia Both DMOG and Ac-LETD-CHO increased HIF-1alpha expression paralleled with the suppression of miR +lncRNA target 31185507 hsa-mir-181 Nerve Degeneration Both DMOG and Ac-LETD-CHO increased HIF-1alpha expression paralleled with the suppression of miR +genetics_GWAS 31185482 hsa-let-7 Endometriosis In a previous study, we demonstrated that a polymorphism in let-7 microRNA-binding site in the 3' untranslated region of the KRAS gene was found in 31% of subjects with endometriosis resistant to medical therapy. CONCLUSION: A germ-line single-nucleotide polymorphism in the let-7 microRNA-binding site of the KRAS gene was not associated with sporadic endometriosis in an infertile Caucasian population in this large case-control study. +circulation_biomarker_diagnosis_up 31185338 hsa-mir-7 Parkinson Disease Here we found that miR-7 was upregulated in brain tissue but downregulated in peripheral blood of rats with ATR-induced PD. +other 31185329 hsa-mir-140 Coronary Artery Disease Analysis of miR-132 and miR3p was assessed in a subset of 70 CAD patients by using qRT-PCR. +other 31185329 hsa-mir-132 Coronary Artery Disease Analysis of miR-132 and miR3p was assessed in a subset of 70 CAD patients by using qRT-PCR. +lncRNA target 31185248 hsa-mir-429 Hypoxia-Ischemia, Brain Taken together, this study demonstrates that silencing of MALAT1 enhances the cerebral protection of DEX against HIBD by suppressing WNT1 expression through miR-429. +genetics_GWAS 31185220 hsa-mir-155 Respiration Disorders These findings indicate that NF-kappaB-mediated miR-155 induces an altered cell cycle through epigenetic modulation of the SOCS1/STAT3 signaling pathway and provide a mechanism for the biphasic effect of different concentrations of PM(2.5) in inducing respiratory injury. +genetics_GWAS 31184921 hsa-mir-126 Myocardial Infarction The single nucleotide polymorphisms (SNPs) rs4636297 and rs1140713 of the miR-126 gene were correlated with the Gensini score, serum BNP, LDL-C, cTnI, and serum vascular endothelial growth factor levels in patients with AMI (p < 0.05). +lncRNA target 31184708 hsa-mir-21 Fibrosis MicroRNA-21 (MiR-21) is a representative microRNA that plays a key role in a variety of fibrotic diseases via the transforming growth factor-beta/Smad signaling pathway. +genetics_overexpression_promote 31184708 hsa-mir-21 Keloid Additionally, at the protein level, our study confirmed that the overexpression of miR-21 could promote the process of keloid fibrosis to some extent and also indicated that a low expression of miR-21 could inhibit the process of keloid fibrosis. +transcription factor target 31184707 hsa-mir-130b Hyperandrogenism Ingenuity(R) Pathway Analysis Core Pathway and Network Analyses suggest a network by which miR-130b-3p, DENND1A, the luteinizing hormone/choriogonadotropin receptor, Ras-related protein 5B, and signaling pathways that they potentially target may mediate hyperandrogenism in PCOS. +genetics_GWAS 31184707 hsa-mir-130b Polycystic Ovary Syndrome Thus, in addition to genetic factors, post-transcriptional regulatory mechanisms via miR-130b-3p underly androgen excess in PCOS. +transcription factor target 31184647 hsa-mir-141 Colorectal Neoplasms We developed a molecular beacon targeting miR3p, aberrantly increased in 5-fluorouracil-resistant colorectal cancer cells (R-CRCCs). +epigenetics 31184607 hsa-mir-127 Breast Neoplasms Notably, the MIR-127 gene was hypermethylated only in the tumor samples of patients with metastases, and, therefore, should be tested as a marker of breast cancer dissemination. +transcription factor target 31184216 hsa-mir-140 Breast Neoplasms Among them, miR5p was found to be downregulated in breast cancer and directly targeted GLUT1, resulting in an antiglycolytic and antiproliferative effect. +lncRNA target 31183875 hsa-mir-147b Tuberous Sclerosis 1 induced dysregulation of MMP3, TIMP2, TIMP3 and TIMP4 could be rescued by miR146a and miR147b in tuber-derived TSC cultures. +lncRNA target 31183875 hsa-mir-146a Tuberous Sclerosis 1 induced dysregulation of MMP3, TIMP2, TIMP3 and TIMP4 could be rescued by miR146a and miR147b in tuber-derived TSC cultures. +lncRNA target 31183860 hsa-mir-24 Colonic Neoplasms Overall, our results showed that LINC00261 repressed colon cancer progression via regulating miR +lncRNA target 31183682 hsa-mir-29b Cardiomegaly Collectively, our findings confirmed that TUG1 functioned as a positive modulator of cardiac hypertrophy via sponging miR-29b-3p, indicating that TUG1 might serve as a potential target for the treatment of cardiac hypertrophy and even heart failure. +lncRNA target 31183590 hsa-mir-503 Stomach Neoplasms Taken together, our results demonstrated that IGF2-AS takes important regulatory parts in GAC development by functioning as a ceRNA to regulate SHOX2 via sponging miR-503. +circRNA target 31182928 hsa-mir-31 Stomach Neoplasms 3p/TGFBR1 axis affected the proliferation, migration, invasion and EMT of GC through the mechanism of competing endogenous RNAs (ceRNA). +transcription factor target 31182926 hsa-mir-146a Carcinoma, Non-Small-Cell Lung In general, our results proved that CT could restrain NSCLC via miR-146a-5p/EGFR axis. CT and miR-146a-5p have the potential to be positive candidates in drug development of NSCLC. +lncRNA target 31182781 hsa-let-7f Multiple Myeloma Our studies suggest that Let-7f, in combination other miRs which are frequently and significantly deregulated in patients with overt MM, targets genes that regulate intron excision. +lncRNA target 31182759 hsa-mir-34a Urinary Bladder Neoplasms The results show that the lncRNAs CARMN, FENDRR and ADAMTS9-AS2 may regulate MEG3 in NMIBC through sponging some important miRNAs such as miR3p, miR-106a-5p and miR-34a-3p. +lncRNA target 31182759 hsa-mir-106a Urinary Bladder Neoplasms The results show that the lncRNAs CARMN, FENDRR and ADAMTS9-AS2 may regulate MEG3 in NMIBC through sponging some important miRNAs such as miR3p, miR-106a-5p and miR-34a-3p. +genetics_overexpression_promote 31182630 hsa-mir-106a Stomach Neoplasms Mechanistic investigations revealed that GAS5 overexpression inactivated the Akt/mTOR pathway by suppressing miRNA-106a-5p expression in vitro and in vivo Taken together, our findings conclude the GAS5 overexpression suppresses tumorigenesis and development of gastric cancer by sponging miR-106a-5p through the Akt/mTOR pathway. +transcription factor target 31182601 hsa-mir-484 Opitz GBBB Syndrome, X-Linked AMPK phosphorylation of NCL sequesters it in the nucleus, thereby inhibiting miR-93 and miR-484 processing and their subsequent targeting of KLF2 and eNOS mRNA. +transcription factor target 31182601 hsa-mir-93 Opitz GBBB Syndrome, X-Linked AMPK phosphorylation of NCL sequesters it in the nucleus, thereby inhibiting miR-93 and miR-484 processing and their subsequent targeting of KLF2 and eNOS mRNA. +other 31182601 hsa-mir-484 Coronary Artery Disease Elevated levels of miR-93 and miR-484 were found in sera collected from individuals afflicted with coronary artery disease in two cohorts. These findings provide translational relevance of the AMPK-NCL-miR-93/miR-484 axis in miRNA processing in EC health and coronary artery disease. +other 31182601 hsa-mir-93 Coronary Artery Disease Elevated levels of miR-93 and miR-484 were found in sera collected from individuals afflicted with coronary artery disease in two cohorts. These findings provide translational relevance of the AMPK-NCL-miR-93/miR-484 axis in miRNA processing in EC health and coronary artery disease. +genetics_GWAS 31182356 hsa-mir-1179 Abortion, Habitual CONCLUSIONS: The miR-150G>A and miR-1179A>T polymorphisms were more frequently associated with RPL compared with controls. +epigenetics 31182225 hsa-mir-124-2 Cervical Intraepithelial Neoplasia Therefore, FAM19A4/miR124-2 methylation analysis is a promising alternative to cytology for triage of HPV positive women. +circulation_biomarker_diagnosis_up 31182094 hsa-mir-26b Neurodegenerative Diseases CONCLUSIONS: These results suggest that plasma miR-26b is a potential novel diagnostic biomarker of DM. +genetics_GWAS 31181801 hsa-mir-379 Lung Neoplasms We identified 10 significantly overmutated hotspot miRNA genes, including the miR-379 gene in LUAD enriched in mutations in the mature miRNA and regulatory sequences. +lncRNA target 31181445 hsa-mir-1197 Carcinoma, Non-Small-Cell Lung Through lentiviral transduction, miR-1197 was downregulated in two NSCLC cell lines, H510A and A549 cells. +other 31181442 hsa-mir-338 Glioma In summary, our results suggested that LINC00689/miR3p/PKM2 axis might play an essential role in glioma progression. +genetics_overexpression_promote 31181312 hsa-mir-454 Glioblastoma Overexpression of miR +genetics_overexpression_promote 31181310 hsa-mir-204 Colonic Neoplasms 5p and oxaliplatin-loaded silica nanoparticles for enhanced tumor suppression effect in CD44-overexpressed colon adenocarcinoma. +other 31181293 hsa-mir-455 Alzheimer Disease 3p regulate APP processing and protective against mutant APP-induced mitochondrial and synaptic abnormalities in AD. +genetics_overexpression_promote 31180611 hsa-mir-223 Parkinsonian Disorders Overexpression of HO-1 in stressed astroglia has previously been documented in the substantia nigra of idiopathic PD and may promote alpha-synuclein production and toxicity by downmodulating miR-153 and/or miR-223 both within the CNS and in peripheral tissues. +genetics_overexpression_promote 31180611 hsa-mir-153 Parkinsonian Disorders Overexpression of HO-1 in stressed astroglia has previously been documented in the substantia nigra of idiopathic PD and may promote alpha-synuclein production and toxicity by downmodulating miR-153 and/or miR-223 both within the CNS and in peripheral tissues. +exosome 31180587 hsa-mir-199a Reperfusion Injury, Renal Ischemia On the whole, this study demonstrated an antiapoptotic effect of hBMSC-Exos, which protected against I/R injury, via delivering miR-199a-3p to renal cells, downregulating Sema3A expression and thereby activating the AKT and ERK pathways. +lncRNA target 31180579 hsa-mir-375 Leukoencephalopathy, Progressive Multifocal Herein, we show that MCPyV T-antigens induce miR-375, miR-30a-3p and miR-30a-5p expressions, which target multiple key genes involved in autophagy, including ATG7, SQSTM1 (p62) and BECN1. +genetics_overexpression_promote 31180557 hsa-mir-143 Ovarian Neoplasms Additionally, CSTB was significantly overexpressed, whereas miR1433p was downregulated in human OC tissues compared with normal ovarian tissues. +genetics_overexpression_promote 31180541 hsa-mir-221 Carcinoma, Non-Small-Cell Lung In the present study, it was demonstrated that miR2213p was overexpressed in nonsmall cell lung cancer (NSCLC) tissues and cell lines compared with that noted in the normal controls. +genetics_knock down_promote 31180538 hsa-mir-92a Stomach Neoplasms Knockdown of miR92a also reduced SGC7901 cell survival under doxorubicin stimulation. +transcription factor target 31180532 hsa-mir-148a Squamous Cell Carcinoma of Head and Neck To further investigate the functions of miR148a in OSCC, the viability, migration, and invasive abilities of SCC9 cells were investigated following transfection with miR148a mimics or miR148a inhibitor. +other 31180529 hsa-mir-155 Glioma The present study investigated the effects of the combined treatment of two peptide nucleic acids (PNAs), directed against microRNAs involved in caspase3 mRNA regulation (miR1555p and miR2213p) in the temozolomide (TMZ)resistant T98G glioma cell line. +other 31180334 hsa-mir-26b Lymphoma, AIDS-Related miRNA-26b-levels could be a potentially useful biomarker to predict lymphoma response in HCV-NHL patients. +other 31180332 hsa-mir-186 Cholangiocarcinoma MiR5p could influence CCA cell proliferation, migration and metastasis by regulating MORC2. +transcription factor target 31179855 hsa-mir-211 Melanoma Here we study the impact of the tumour suppressive melanoma miRNA miR-211 on transcriptome stability and phenotype in the non-pigmented melanoma cell line, A375. +transcription factor target 31179326 hsa-mir-21 Carcinoma, Renal Cell YAP1, which was identified as a target of miR-21, showed significantly lower expression in RCC tissues than in healthy tissues. In conclusion, Eupatilin inhibited the expression of miR-21, which mediated the proapoptotic and antimigratory effects of Eupatilin by suppressing YAP1 in renal cancer cells. +circulation_biomarker_diagnosis_ns 31179325 hsa-mir-22 Myocardial Infarction We concluded that plasma miR +circulation_biomarker_diagnosis_ns 31179325 hsa-mir-150 Myocardial Infarction We concluded that plasma miR +circulation_biomarker_diagnosis_down 31179325 hsa-mir-132 Myocardial Infarction 5p, but circulating miR +genetics_overexpression_suppress 31179240 hsa-mir-224 Glioma Overexpression of miR +genetics_overexpression_suppress 31178968 hsa-mir-27b Fibrosis, Atrial Our results showed that miR-27b-3p overexpression could reduce the incidence and duration of AF, alleviate atrial fibrosis, increase atrial CX43 expression, and decrease the expression of Collagen-I, a-SMA, Collagen-III, TGF-beta1, Wnt3a, and p-beta-Catenin. +genetics_overexpression_suppress 31178968 hsa-mir-27b Atrial Fibrillation Our results showed that miR-27b-3p overexpression could reduce the incidence and duration of AF, alleviate atrial fibrosis, increase atrial CX43 expression, and decrease the expression of Collagen-I, a-SMA, Collagen-III, TGF-beta1, Wnt3a, and p-beta-Catenin. +other 31178952 hsa-mir-181c Myocardial Infarction Clinical evidence demonstrated that miR-181c-5p was significantly upregulated in the early phase of myocardial infarction. +transcription factor target 31178952 hsa-mir-181c Iris Diseases However, whether or not miR-181c-5p mediates cardiac I/RI through cell apoptosis pathway is unknown. In line with this, in an in vivo rat cardiac I/RI model, miR-181c-5p expression was also significantly increased. +genetics_knock down_promote 31178864 hsa-mir-152 Lupus Erythematosus, Systemic Knockdown of miR +other 31178808 hsa-mir-146a Sleep Initiation and Maintenance Disorders Moreover, the relationship between distress induced by exposure to negative social acts and insomnia was significantly stronger for individuals with the miR-146a GG genotype. Thus, the miR-146a genotype moderated the association between distress and insomnia among individuals exposed to negative social acts. +other 31178586 hsa-mir-378a Cataract CONCLUSIONS In HLECs, expression of miR-378a regulated ROS and PI3K/AKT signaling, and miR-378a was upregulated, and SOD1 was down-regulated in human cataract tissue. +transcription factor target 31177707 hsa-mir-29c Pulmonary Fibrosis Conclusion: Based on the findings, it could be safely infered that the development of pulmonary fibrosis could be impeded by inhibiting transdifferentiation process of pulmonary fibroblasts into myofibroblasts regulated by miR-29c, miR-29c could be an potential therapeutic target to lung fibrosis induced by silica. +other 31177707 hsa-mir-29c Silicotuberculosis Results: Compared with control group, the expression level of miR-29c in the silicosis cell model in vitro was down-regulated significantly after 12 or 18 h exposed to SiO(2), and both of the mRNA and protein expression levels of alpha-SMA were up-regulated instead (P<0.05) . +transcription factor target 31177529 hsa-mir-155 Uveitis In this work, we identify a decrease in miR-155 in suppressor macrophages and further examine how tissue-specific production of miR-155 impacts experimental autoimmune uveitis. In summary, we find a MC5r-dependent decrease in miR-155 in postexperimental autoimmune uveitis APC, miR-155 production by the target tissue is necessary for the initiation of autoimmune uveitis, and may have a role in establishing protective regulatory immunity. +epigenetics 31177462 hsa-mir-34b Ovarian Neoplasms Using methylation-specific PCR and a representative set of 54 ovarian cancer samples, we identified 10 microRNA genes (MIR-124a-2, MIR-127, MIR-125b-1, MIR2, MIR-137, MIR-193a, MIR-203a, MIR-34b/c, MIR-130b, and MIR-1258) whose methylation is associated with tumor metastasis. +epigenetics 31177462 hsa-mir-137 Ovarian Neoplasms Using methylation-specific PCR and a representative set of 54 ovarian cancer samples, we identified 10 microRNA genes (MIR-124a-2, MIR-127, MIR-125b-1, MIR2, MIR-137, MIR-193a, MIR-203a, MIR-34b/c, MIR-130b, and MIR-1258) whose methylation is associated with tumor metastasis. +epigenetics 31177462 hsa-mir-124a-2 Ovarian Neoplasms Using methylation-specific PCR and a representative set of 54 ovarian cancer samples, we identified 10 microRNA genes (MIR-124a-2, MIR-127, MIR-125b-1, MIR2, MIR-137, MIR-193a, MIR-203a, MIR-34b/c, MIR-130b, and MIR-1258) whose methylation is associated with tumor metastasis. +epigenetics 31177462 hsa-mir-127 Ovarian Neoplasms Using methylation-specific PCR and a representative set of 54 ovarian cancer samples, we identified 10 microRNA genes (MIR-124a-2, MIR-127, MIR-125b-1, MIR2, MIR-137, MIR-193a, MIR-203a, MIR-34b/c, MIR-130b, and MIR-1258) whose methylation is associated with tumor metastasis. +epigenetics 31177462 hsa-mir-203a Ovarian Neoplasms Using methylation-specific PCR and a representative set of 54 ovarian cancer samples, we identified 10 microRNA genes (MIR-124a-2, MIR-127, MIR-125b-1, MIR2, MIR-137, MIR-193a, MIR-203a, MIR-34b/c, MIR-130b, and MIR-1258) whose methylation is associated with tumor metastasis. +epigenetics 31177462 hsa-mir-129-2 Ovarian Neoplasms Using methylation-specific PCR and a representative set of 54 ovarian cancer samples, we identified 10 microRNA genes (MIR-124a-2, MIR-127, MIR-125b-1, MIR2, MIR-137, MIR-193a, MIR-203a, MIR-34b/c, MIR-130b, and MIR-1258) whose methylation is associated with tumor metastasis. +epigenetics 31177462 hsa-mir-125b-1 Ovarian Neoplasms Using methylation-specific PCR and a representative set of 54 ovarian cancer samples, we identified 10 microRNA genes (MIR-124a-2, MIR-127, MIR-125b-1, MIR2, MIR-137, MIR-193a, MIR-203a, MIR-34b/c, MIR-130b, and MIR-1258) whose methylation is associated with tumor metastasis. +epigenetics 31177462 hsa-mir-193a Ovarian Neoplasms Using methylation-specific PCR and a representative set of 54 ovarian cancer samples, we identified 10 microRNA genes (MIR-124a-2, MIR-127, MIR-125b-1, MIR2, MIR-137, MIR-193a, MIR-203a, MIR-34b/c, MIR-130b, and MIR-1258) whose methylation is associated with tumor metastasis. +epigenetics 31177462 hsa-mir-34c Ovarian Neoplasms Using methylation-specific PCR and a representative set of 54 ovarian cancer samples, we identified 10 microRNA genes (MIR-124a-2, MIR-127, MIR-125b-1, MIR2, MIR-137, MIR-193a, MIR-203a, MIR-34b/c, MIR-130b, and MIR-1258) whose methylation is associated with tumor metastasis. +epigenetics 31177462 hsa-mir-1258 Ovarian Neoplasms Using methylation-specific PCR and a representative set of 54 ovarian cancer samples, we identified 10 microRNA genes (MIR-124a-2, MIR-127, MIR-125b-1, MIR2, MIR-137, MIR-193a, MIR-203a, MIR-34b/c, MIR-130b, and MIR-1258) whose methylation is associated with tumor metastasis. +epigenetics 31177462 hsa-mir-130b Ovarian Neoplasms Using methylation-specific PCR and a representative set of 54 ovarian cancer samples, we identified 10 microRNA genes (MIR-124a-2, MIR-127, MIR-125b-1, MIR2, MIR-137, MIR-193a, MIR-203a, MIR-34b/c, MIR-130b, and MIR-1258) whose methylation is associated with tumor metastasis. +other 31177123 hsa-mir-449a Colorectal Neoplasms In this study, the significance of miR-449a in the prognosis and relationship with HDAC1 in colorectal cancer was examined. CONCLUSION: miR-449a level might be a prognostic indicator for colorectal cancer and miR-449a might regulate HDAC1 expression. +lncRNA target 31176784 hsa-mir-186 Carcinoma, Non-Small-Cell Lung Depletion of miR-186 significantly reversed the suppressive effect of lycorine on the proliferation of NSCLC cells. +circulation_biomarker_diagnosis_up 31176780 hsa-mir-1303 Myocardial Infarction, Acute KEY FINDINGS: Serum miR-208, miR-494, miR-499 and miR-1303 expression levels at different time points were significantly higher in the AMI group than in the SAP group and control group. +circulation_biomarker_diagnosis_up 31176780 hsa-mir-499 Myocardial Infarction, Acute KEY FINDINGS: Serum miR-208, miR-494, miR-499 and miR-1303 expression levels at different time points were significantly higher in the AMI group than in the SAP group and control group. +circulation_biomarker_diagnosis_up 31176780 hsa-mir-494 Myocardial Infarction, Acute KEY FINDINGS: Serum miR-208, miR-494, miR-499 and miR-1303 expression levels at different time points were significantly higher in the AMI group than in the SAP group and control group. +circulation_biomarker_diagnosis_up 31176780 hsa-mir-208 Myocardial Infarction, Acute KEY FINDINGS: Serum miR-208, miR-494, miR-499 and miR-1303 expression levels at different time points were significantly higher in the AMI group than in the SAP group and control group. +lncRNA target 31176779 hsa-mir-21 Adenocarcinoma of Lung CONCLUSION: We suggest that SET/TAF-Ialpha might be a tumor suppressing factor regulated by miR5p in lung adenocarcinoma. +circulation_biomarker_diagnosis_ns 31176730 hsa-mir-23b Arthritis, Rheumatoid Appropriate treatment for RA not only ameliorated the disease condition but also reversed the elevated plasma miR-23b level remarkably. +genetics_overexpression_promote 31176678 hsa-mir-188 Carcinoma, Hepatocellular INTERPRETATION Our study indicates that NCAPG2 overexpression could drive HCC proliferation and metastasis through activation of the STAT3 and NF-B/miR +genetics_overexpression_promote 31176655 hsa-mir-186 Aneuploidy These results suggest that overexpression of miR-186 in arsenic exposed tissues likely induces aneuploidy contributing to arsenic-induced carcinogenesis. +transcription factor target 31176490 hsa-mir-140 Neuralgia 3p may provide a new regulatory target for preventing the effects of neonatal repetitive pain. +other 31176168 hsa-mir-7 Carcinoma, Non-Small-Cell Lung CONCLUSION Let-7c-5p, miR-148a-3p, miR-148a-5p, and miR5p are favorable indicators of NSCLC patients treated with honokiol. +lncRNA target 31176167 hsa-mir-503 Osteoarthritis 5p inhibited the function of miR-503 and attenuated the inhibition of OA on osteoclastogenesis, suggesting that OA inhibited osteoclast by up-regulating miR-503 expression. +genetics_knock down_promote 31176165 hsa-mir-1307 Carcinoma, Hepatocellular DAB2IP knockdown rescued miR +genetics_GWAS 31176032 hsa-mir-100 Hepatitis B This study focused on a miR-100 Single Nucleotide Polymorphism (SNP) (rs1834306 T/C) and its contribution to an individual's susceptibility and prognosis of HBV infection. +genetics_GWAS 31176032 hsa-mir-100 Hepatitis B, Chronic This study focused on a miR-100 Single Nucleotide Polymorphism (SNP) (rs1834306 T/C) and its contribution to an individual's susceptibility and prognosis of HBV infection. +other 31175974 hsa-mir-892b Tuberculosis 5p could be considered promising novel diagnostic biomarkers for active tuberculosis. +other 31175974 hsa-mir-199b Tuberculosis 5p could be considered promising novel diagnostic biomarkers for active tuberculosis. +other 31175974 hsa-mir-582 Tuberculosis 5p could be considered promising novel diagnostic biomarkers for active tuberculosis. +transcription factor target 31175931 hsa-mir-29c Cardiomyopathies Taken together, our data demonstrated that the Smad3-miR-29b/miR-29c axis mediates the inhibitory effect of macrophage migration inhibitory factor on cardiac fibrosis. +transcription factor target 31175931 hsa-mir-29b Cardiomyopathies Taken together, our data demonstrated that the Smad3-miR-29b/miR-29c axis mediates the inhibitory effect of macrophage migration inhibitory factor on cardiac fibrosis. +genetics_overexpression_promote 31175094 hsa-mir-214 Pancreatic Carcinoma A combination of OGDHL downregulation and TWIST1 and miR-214 overexpression predicted worse prognosis in patients with pancreatic cancer. +other 31174625 hsa-mir-338 Chorioamnionitis miR-518b and miR3p were differentially expressed between aCA cases and non-aCA cases (Bonferroni-corrected p<0.05). +lncRNA target 31174540 hsa-mir-10b Acute Lung Injury CONCLUSION: EPC transplantation exerted its therapeutic effect of ALI via increasing miR-10a/b-5p and reducing ADAM15, thus providing a novel insight into the molecular mechanism of EPC transplantation in treating ALI. +lncRNA target 31174540 hsa-mir-10a Acute Lung Injury CONCLUSION: EPC transplantation exerted its therapeutic effect of ALI via increasing miR-10a/b-5p and reducing ADAM15, thus providing a novel insight into the molecular mechanism of EPC transplantation in treating ALI. +exosome 31174402 hsa-mir-198 Newcastle Disease Three miRNA candidates (miR-1273f, miR-1184, and miR-198) embraced by exosomes were associated with enhancing NDV-induced cytopathic effects on HeLa cells. +exosome 31174402 hsa-mir-1273f Newcastle Disease Three miRNA candidates (miR-1273f, miR-1184, and miR-198) embraced by exosomes were associated with enhancing NDV-induced cytopathic effects on HeLa cells. +exosome 31174402 hsa-mir-1184 Newcastle Disease Three miRNA candidates (miR-1273f, miR-1184, and miR-198) embraced by exosomes were associated with enhancing NDV-induced cytopathic effects on HeLa cells. +genetics_overexpression_promote 31174090 hsa-mir-485 Carcinoma, Hepatocellular Long noncoding RNA BLACAT1 is overexpressed in hepatocellular carcinoma and its downregulation suppressed cancer cell development through endogenously competing against hsa-miR +genetics_knock down_promote 31174089 hsa-mir-9 Sepsis Notably, ANO1 overexpression or Smad2 knockdown attenuated miR-9 knockdown-mediated inhibition on LPS-induced sepsis. +other 31173848 hsa-mir-9 Alzheimer Disease Interestingly, DKK1 transcript level was reduced dramatically after DA induction in TM-MSCs which was accompanied by an increase in the in silico-predicted MIR9 and MIR101 levels. Therefore miR-9 and miR-101 might explain, at least in part, the underlying regulatory mechanism of DKK1 reduction and resulting Wnt/beta-catenin pathway activation during DA neuron differentiation process. +other 31173848 hsa-mir-101 Alzheimer Disease Interestingly, DKK1 transcript level was reduced dramatically after DA induction in TM-MSCs which was accompanied by an increase in the in silico-predicted MIR9 and MIR101 levels. Therefore miR-9 and miR-101 might explain, at least in part, the underlying regulatory mechanism of DKK1 reduction and resulting Wnt/beta-catenin pathway activation during DA neuron differentiation process. +genetics_knock down_promote 31173403 hsa-mir-4677 Adenocarcinoma of Lung 3p rescued the inhibitive impacts of TTN-AS1 knockdown on lung adenocarcinoma. +lncRNA target 31173354 hsa-mir-495 Colonic Neoplasms 3p to contribute to colon cancer progression through activating CDK6. +lncRNA target 31173352 hsa-mir-495 Melanoma In conclusion, we suggest that NEAT1 exerts an oncogenic effect on melanoma development via inhibition of miR +transcription factor target 31173317 hsa-mir-23 Atrial Fibrillation CONCLUSIONS: Our findings indicated that miR-23 could promote the progression of AF via promoting TGF-beta1, which might serve as a new direction for interpreting the mechanism of AF development. +other 31173306 hsa-mir-488 Diabetic Nephropathies OBJECTIVE: The aim of this study was to clarify the biological roles of microRNA-488 and transforming growth factor beta1 (TGF-beta1) pathway in the occurrence and progression of diabetic nephropathy (DN). CONCLUSIONS: MicroRNA-488 regulates the development of diabetic nephropathy-induced fibrosis by TGF-beta1 pathway. +genetics_overexpression_promote 31173299 hsa-mir-154 Melanoma Besides, miR-154 overexpression rescued the suppressive effect of AURKA-mediated melanoma on cell proliferation, colony formation, and metastasis. +genetics_overexpression_promote 31173298 hsa-mir-139 Glioblastoma Finally, overexpression of NOB1 neutralized the inhibition of miR +lncRNA target 31173297 hsa-mir-374b Glioma CONCLUSIONS: MicroRNA-374b could inhibit the invasion and migration of glioma by regulating EGFR. +lncRNA target 31173294 hsa-mir-221 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: MiR-221 promotes the apoptosis of NSCLC cells through negative regulation of lncRNA HOTAIR, which can be used in the treatment of NSCLC. +genetics_overexpression_promote 31173287 hsa-mir-1238 Stomach Neoplasms Furthermore, overexpression of miRNA +genetics_overexpression_promote 31173278 hsa-mir-204 Spinal Cord Injuries Moreover, the simultaneous overexpression of SOX11 and microRNA +lncRNA target 31173277 hsa-mir-205 Rotator Cuff Injuries CONCLUSIONS: VEGFA promotes tendon-bone healing of RCT via inhibiting microRNA5p expression. +epigenetics 31173259 hsa-mir-29 Burkitt Lymphoma The treatment of BL cells with decitabine reduced methylation, induced miR29s expression and downregulated MYC protein levels in a dosedependent manner. +virus_miRNA 31173259 ebv-mir-BART6 Burkitt Lymphoma Inhibition of EBV miR-BART6-5p combined with decitabine enhanced miR-29 expression in an EBV-BL cell line. +lncRNA target 31173245 hsa-mir-204 Breast Neoplasms A luciferase assay demonstrated a direct binding site for miR204 within ATXN8OS, and inhibition of miR204 stimulated the tumourpromoting effect of ATXN8OS on BC cells. +transcription factor target 31173241 hsa-mir-520a Retinoblastoma The results indicated that lidocaine reduced the proliferation and induced the apoptosis of RB cells by decreasing EGFR expression via the upregulation of miR520a3p, suggesting that the miR520a3p/EGFR axis may be a novel therapeutic target in the treatment of RB. +other 31173239 hsa-mir-802 Insulin Resistance In conclusion, the results demonstrate that miR802 may cause IR by activating the JNK and p38MAPK pathways to increase hepatic oxidative stress. +genetics_overexpression_promote 31173238 hsa-mir-379 Carcinoma, Non-Small-Cell Lung The overexpression of miR379 may prevent the growth of NSCLC tumors via CHUK suppression and the downstream nuclear factorkappaB pathway. +genetics_overexpression_promote 31173237 hsa-mir-106b Prostatic Neoplasms In this study, miR106b was reported to be overexpressed and larelated protein 4B (LARP4B) was downregulated in PCa tissues compared with paracancerous tissues. +circulation_biomarker_diagnosis_down 31173234 hsa-mir-451 Brain Ischemia Firstly, a miRNA microarray was performed to analyze miRNA expression in serum samples from patients with cerebral ischemia and the results revealed that miR451 was one of the miRNAs that was the most significantly downregulated. +transcription factor target 31173234 hsa-mir-451 Cerebrooculofacioskeletal Syndrome 2 These results revealed that downregulation of miR451 promotes angiogenesis by targeting MIF in hypoxic HUVECs and indicated that miR451 is a potential candidate for CII therapeutics. +genetics_overexpression_promote 31173214 hsa-mir-589 Prostatic Neoplasms Overexpression of miR5895p inhibited cell viability, migration and invasion in prostate cancer cells. +other 31173209 hsa-mir-26b Thyroid Neoplasms The expression levels of miR26b5p were detected in TC and paracarcinoma tissues by quantitative polymerase chain reaction, and the association between miR26b5p expression and the clinicopathological features of the patients was analyzed using ttest or oneway analysis of variance. The results demonstrated that the expression levels of miR26b5p were significantly lower in TC tissues compared with paracarcinoma tissues (P<0.01), and miR26b5p was associated with lymph node metastasis (P<0.05). +other 31173206 hsa-mir-422a Osteosarcoma CTPS2, TP53I3 and SLC1A1 may serve major roles in osteosarcoma development, and hsamiR422a, hsamiR194, MMP3 and VEGFB may be associated with osteosarcoma metastasis. +other 31173206 hsa-mir-194 Osteosarcoma CTPS2, TP53I3 and SLC1A1 may serve major roles in osteosarcoma development, and hsamiR422a, hsamiR194, MMP3 and VEGFB may be associated with osteosarcoma metastasis. +genetics_overexpression_suppress 31173204 hsa-mir-27a Reperfusion Injury, Renal Ischemia The overexpression of miR27a downregulated the expression of TLR4, which in turn inhibited the inflammation, cell adhesion and cell death in IRI. +lncRNA target 31173203 hsa-mir-214 Colorectal Neoplasms Notably, miR214 markedly suppressed the viability, invasion and migration of CRC cells, which may be associated with a downregulation in PI3K/Akt signaling. +other 31173188 hsa-mir-24 Nerve Degeneration The present study investigated the involvement of a microRNA24 (miR24)toScgn regulatory pathway in cholesterolinduced betacell dysfunction. The present study concluded that a miR24toScgn pathway participates in the mechanism regulating cholesterol accumulationinduced betacell dysfunction. +transcription factor target 31173169 hsa-mir-141 Hepatitis, Alcoholic The present study aims to investigate the role of miR141 in intestinal injury and IETM of AH. Collectively, the results of the present study demonstrated that miR141 could ameliorate intestinal injury and repress the progression of IETM through targeting TLR4 and inhibiting the TLR pathway. +transcription factor target 31173169 hsa-mir-141 Intestinal Diseases The present study aims to investigate the role of miR141 in intestinal injury and IETM of AH. Collectively, the results of the present study demonstrated that miR141 could ameliorate intestinal injury and repress the progression of IETM through targeting TLR4 and inhibiting the TLR pathway. +genetics_knock down_suppress 31173161 hsa-mir-340 Carcinoma, Non-Small-Cell Lung miR340 overexpression inhibited the migration and invasion of the NSCLC cells by targeting RAB27B, while the knockdown of miR340 exerted opposite effects. +lncRNA target 31173154 hsa-mir-381 Pancreatic Carcinoma It was also demonstrated that miR381 serves a key role in pancreatic cancer cells through regulating the phosphoinositide 3kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway. +genetics_overexpression_suppress 31172560 hsa-mir-181c Irritable Bowel Syndrome Collectively, this study suggested that overexpressed miR-181c-5p could silence IL1A, thus inhibiting low-grade inflammation in IBS rats. +genetics_overexpression_suppress 31172560 hsa-mir-181c Inflammation Collectively, this study suggested that overexpressed miR-181c-5p could silence IL1A, thus inhibiting low-grade inflammation in IBS rats. +lncRNA target 31171769 hsa-mir-708 Glioma In summary, our findings revealed that miR-708 is a glioma tumor suppressor and suggest that miR-708 is a potential therapeutic target for glioma patients. +genetics_overexpression_promote 31171711 hsa-mir-876 Stomach Neoplasms 5p overexpression repressed proliferative, anti-apoptotic and migratory abilities and epithelial-mesenchymal transition (EMT) of GC cells. +transcription factor target 31171361 hsa-mir-374a Fibrosis In the present study, we attempted to investigate the mechanism of iron overload in hepatic fibrosis from the perspective of regulating HSC activation via oxidative stress and miR-374a/Myc axis. +other 31170665 hsa-mir-34a Esophageal Squamous Cell Carcinoma CONCLUSIONS: Taken together, we demonstrated that lncRNA MNX1-AS1/miR-34a/SIRT1 regulatory axis could play an important role in ESCC progression, and MNX1-AS1 may act as a novel potential biomarker for esophageal squamous cell carcinoma. +other 31170663 hsa-mir-126 Brain Injuries Atorvastatin significantly increased EGFL7 and down-regulated miR-126 expression in TBI rats brain tissues compared to Model group (p < 0.05). miR-126 interacted with and negatively correlated with EGFL7 gene both in vitro and in TBI models. +lncRNA target 31170211 hsa-mir-582 Carcinoma, Non-Small-Cell Lung 5p suppresses NSCLC cell lines' growth and invasion via targeting oncoprotein NOTCH1 and restoration of miR +other 31170091 hsa-mir-19a Brain Ischemia This study demonstrates that the identified H19-miR-19a-Id2 axis plays a critical role in hypoxia induced neuronal apoptosis, and blocking this axis may serve as a novel therapeutic strategy for ischemic brain injury. +genetics_overexpression_promote 31170011 hsa-mir-383 Stomach Neoplasms Functional analysis showed that overexpression of miR-383 inhibited the proliferation and upregulated the apoptosis of gastric cancer cells. +lncRNA target 31169973 hsa-mir-199a Osteosarcoma Then, hsa-miR-199a-3p was downregulated in NORAD-inhibited osteosarcoma cells to examine its role in regulating NORAD inhibition induced cancer suppression in osteosarcoma cells. The results of our study show that NORAD plays an important role in regulating cancer cell functions of osteosarcoma, possibly through endogenously competing with hsa-miR-199a-3p. +other 31169351 hsa-mir-27 Myocardial Ischemia Furthermore, miR-27/ TGFBR1 might be utilized as hopeful biomarkers for myocardial ischemia diagnosis and treatment. +genetics_overexpression_suppress 31169343 hsa-mir-145 Squamous Cell Carcinoma of Head and Neck 5p overexpressed LSCC cells. +other 31169310 hsa-mir-200b Carcinoma, Non-Small-Cell Lung In addition, CDC25A, miR-200a, miR-200b, miR-200c, miR-130b, and miR-590 are potential prognostic indicators of LSCC. +other 31169310 hsa-mir-200a Carcinoma, Non-Small-Cell Lung In addition, CDC25A, miR-200a, miR-200b, miR-200c, miR-130b, and miR-590 are potential prognostic indicators of LSCC. +other 31169310 hsa-mir-130b Carcinoma, Non-Small-Cell Lung In addition, CDC25A, miR-200a, miR-200b, miR-200c, miR-130b, and miR-590 are potential prognostic indicators of LSCC. +genetics_overexpression_suppress 31169309 hsa-mir-5095 Uterine Cervical Neoplasms A combination of radiotherapy with LINC00958 silencing, RRM2 downregulation or miR-5095 overexpression was found to inhibit cervical cancer cell proliferation and tumor growth, while promoting cell apoptosis both in vitro and in vivo. +lncRNA target 31169033 hsa-let-7d Glioblastoma Previously, we demonstrated that Olea europaea leaf extract (OLE) kills GBM cells by modulating miR-181b, miR-137, miR-153 and Let-7d expression. In conclusion, OL has an antitumour effect on GBM cells mainly via regulation of Let-7d expression. +other 31169020 hsa-mir-214 Urinary Bladder Neoplasms The expression of miRNA (hsa-mir-214), circRNA (hsa_circ_0076704, hsa_circ_0081963, hsa_circ_0001361) in bladder cancer tissues, adjacent tissues, bladder cancer cells and normal bladder epithelial cells were validated by qRT-PCR. Further prognostic analysis showed that circRNA interacted miRNA hsa-miR-106b, hsa-miR-145 and hsa-miR-214 were associated with overall survival in patients with bladder cancer (P < 0.05). +genetics_overexpression_promote 31169019 hsa-mir-21 Breast Neoplasms 5p silencing or PDCD4 overexpression ameliorated PTX resistance and inhibited the progression in PTX-resistant BC cell lines. +other 31168988 hsa-mir-29a Hyperlipidemias This result implies that miR-29a-3p can promote implant osseointergration in a rat model of hyperlipidemia. +lncRNA target 31168823 hsa-mir-146 Carcinoma, Hepatocellular To sum up, F11-AS1 suppresses LIHC progression by competitively binding with miR-3146 to regulate PTEN expression. +lncRNA target 31168689 hsa-mir-142 Adenocarcinoma of Lung 3p inhibits lung adenocarcinoma cell proliferation, migration and invasion, and enhances cell apoptosis by targeting NR2F6, suggesting that miR +other 31168459 hsa-mir-558 Acute Kidney Injury 5p, et al.) in the kidneys of CI-AKI rats according to log2 (fold change, control) >1, P<0.001 as significant differently expressed miRNAs, which included new differently expressed miRNAs, such as miRNA-1949 and miR-3558. +other 31168459 hsa-mir-384 Acute Kidney Injury 5p, et al.) in the kidneys of CI-AKI rats according to log2 (fold change, control) >1, P<0.001 as significant differently expressed miRNAs, which included new differently expressed miRNAs, such as miRNA-1949 and miR-3558. +other 31168459 hsa-mir-1949 Acute Kidney Injury 5p, et al.) in the kidneys of CI-AKI rats according to log2 (fold change, control) >1, P<0.001 as significant differently expressed miRNAs, which included new differently expressed miRNAs, such as miRNA-1949 and miR-3558. +other 31168459 hsa-mir-328a Acute Kidney Injury 5p, et al.) in the kidneys of CI-AKI rats according to log2 (fold change, control) >1, P<0.001 as significant differently expressed miRNAs, which included new differently expressed miRNAs, such as miRNA-1949 and miR-3558. +other 31168459 hsa-mir-1 Acute Kidney Injury 5p, et al.) in the kidneys of CI-AKI rats according to log2 (fold change, control) >1, P<0.001 as significant differently expressed miRNAs, which included new differently expressed miRNAs, such as miRNA-1949 and miR-3558. +other 31168459 hsa-mir-377 Acute Kidney Injury 5p, et al.) in the kidneys of CI-AKI rats according to log2 (fold change, control) >1, P<0.001 as significant differently expressed miRNAs, which included new differently expressed miRNAs, such as miRNA-1949 and miR-3558. +other 31168459 hsa-mir-34c Acute Kidney Injury 5p, et al.) in the kidneys of CI-AKI rats according to log2 (fold change, control) >1, P<0.001 as significant differently expressed miRNAs, which included new differently expressed miRNAs, such as miRNA-1949 and miR-3558. +genetics_knock down_promote 31168355 hsa-mir-142 Carcinoma, Hepatocellular The knockdown of MALAT1 inhibited the proliferation, migration, invasion, and epithelial cell-to-mesenchymal transition (EMT), and promoted apoptosis of hepatocellular carcinoma cells via miR +genetics_knock down_promote 31168354 hsa-mir-18a Myocardial Infarction, Acute The gain- and loss-of-function experiments were performed to elucidate miR-18a and BDNF effects on cell autophagy and senescence in AMI by transfecting hypoxia-exposed H9c2 cells with miR-18a inhibitor or mimic, siRNA against BDNF, or hypoxia-exposed H9c2 cell treatment with an agonist of the Akt/mTOR axis (LM22B-10). +circulation_biomarker_diagnosis_ns 31168350 hsa-mir-122 Reperfusion Injury RESULTS: The results showed that GA reduced the concentrations of liver enzymes, miR-122, and miR-34a in serum, and preserved liver cells changes induced by I/R injury. +circulation_biomarker_diagnosis_ns 31168350 hsa-mir-34a Reperfusion Injury RESULTS: The results showed that GA reduced the concentrations of liver enzymes, miR-122, and miR-34a in serum, and preserved liver cells changes induced by I/R injury. +transcription factor target 31168302 hsa-mir-19a Ischemic Stroke MiR-19a-3p attenuation thus might offer hope of a novel therapeutic target for ischemic stroke injury treatment. +genetics_overexpression_suppress 31167927 hsa-mir-200a Peritoneal Fibrosis We developed a triad of adeno-associated viruses that overexpressed microRNA-26a and microRNA-200a while inhibiting microRNA-21a to target hyperglycolysis and fibrotic signaling. +genetics_overexpression_suppress 31167927 hsa-mir-26a Peritoneal Fibrosis We developed a triad of adeno-associated viruses that overexpressed microRNA-26a and microRNA-200a while inhibiting microRNA-21a to target hyperglycolysis and fibrotic signaling. +genetics_overexpression_suppress 31167927 hsa-mir-21 Peritoneal Fibrosis We developed a triad of adeno-associated viruses that overexpressed microRNA-26a and microRNA-200a while inhibiting microRNA-21a to target hyperglycolysis and fibrotic signaling. +lncRNA target 31167152 hsa-mir-494 Urinary Bladder Neoplasms Our studies also reveal that ChlA-F is a promising therapeutic compound for BCs and miR-494 could also serve as a promising therapeutic target for the treatment of MIBC patients. +transcription factor target 31166951 hsa-mir-181a Liver Cirrhosis ALR inhibited TGF-beta action by decreasing the expression of TGFbeta-RII, thereby inhibiting miRNA-181a expression and fibrosis markers. +transcription factor target 31165706 hsa-mir-24 Esophageal Neoplasms Together, our data indicate that FERMT1 acts as an oncogene and is negatively regulated by miR-24, supporting the potential therapeutic strategy against esophageal cancer by targeting miRFERMT1 axis. +transcription factor target 31165610 hsa-mir-186 Multiple Myeloma By inhibiting the proliferation of myeloma cells, miR-186 gene and ZNF protein may be used as tumor suppressors in the treatment of myeloma. +genetics_overexpression_promote 31165609 hsa-mir-940 Breast Neoplasms In conclusion, overexpressed LncRNA CTBP1- AS promoted breast cancer cell proliferation, invasion as well as migration, inhibited cell apoptosis and accelerated breast cancer development by sponging microRNA-940. +other 31165544 hsa-mir-181a Head and Neck Neoplasms Combined analysis of miRNA-181a with phase angle derived from bioelectrical impedance predicts radiotherapy-induced changes in body composition and survival of male patients with head and neck cancer. We demonstrated novel approach to prediction of RTH-induced changes in body composition of patients with head and neck cancer using phase angle (PA) derived from bioelectrical impedance in combination with miRNA-181a expression. +other 31165496 hsa-mir-455 salivary gland adenoid cystic carcinoma 3p could be used as a complimentary tool in the diagnosis of challenging AdCC cases. +other 31165496 hsa-mir-150 salivary gland adenoid cystic carcinoma 3p expression in AdCC, PAC and control was not associated with age, gender nor with anatomic site (major and minor salivary glands) (P > 0.05). +transcription factor target 31165485 hsa-mir-409 Osteoporosis, Postmenopausal Thus, targeting miR5p may be helpful in increasing bone density in conditions like post menopausal osteoporosis. +transcription factor target 31165412 hsa-mir-410 ACTH-Secreting Pituitary Adenoma 3p acts as an oncomiR in gonadotroph and corticotroph adenoma cells, while as a tumor suppressor miR in somatotroph adenoma cells. +transcription factor target 31165412 hsa-mir-410 Somatotroph Adenomas 3p acts as an oncomiR in gonadotroph and corticotroph adenoma cells, while as a tumor suppressor miR in somatotroph adenoma cells. +genetics_overexpression_promote 31165315 hsa-mir-101 Mouth Neoplasms Meanwhile, exosomes derived from hBMSCs were isolated and then co-cultured with oral cancer cells to identify the role of exosomes, and the results suggested that hBMSCs-derived exosomes overexpressing miR +other 31164867 hsa-mir-200a Fibrosis In mechanistic studies, the transfection of miR 192 in HK-2 cells increased miR 200a expression and decreased ZEB2, a key transcriptional promoter of kidney fibrosis. +other 31164867 hsa-mir-200b Weight Loss Results: Levels of miR 192, miR 200a, and miR 200b were upregulated in urine following bariatric surgery. +other 31164867 hsa-mir-200 Weight Loss Results: Levels of miR 192, miR 200a, and miR 200b were upregulated in urine following bariatric surgery. +other 31164867 hsa-mir-192 Obesity, Morbid Bariatric surgery alters urinary miR 192 expression from levels seen in morbidly obese patients to levels seen in healthy weight control patients. +other 31164867 hsa-mir-192 Weight Loss Results: Levels of miR 192, miR 200a, and miR 200b were upregulated in urine following bariatric surgery. +other 31164867 hsa-mir-200a Weight Loss Results: Levels of miR 192, miR 200a, and miR 200b were upregulated in urine following bariatric surgery. +other 31164867 hsa-mir-200 Fibrosis In mechanistic studies, the transfection of miR 192 in HK-2 cells increased miR 200a expression and decreased ZEB2, a key transcriptional promoter of kidney fibrosis. +other 31164867 hsa-mir-192 Fibrosis In mechanistic studies, the transfection of miR 192 in HK-2 cells increased miR 200a expression and decreased ZEB2, a key transcriptional promoter of kidney fibrosis. +genetics_overexpression_promote 31164807 hsa-mir-210 Osteochondritis Dissecans 3p overexpression enhances the angiogenic properties of OGD-treated EPCs by inhibiting RGMA. +transcription factor target 31164807 hsa-mir-210 Ischemia 3p mimic and inhibitor into EPCs, and after 24 h, we exposed them to OGD conditions for 4 h to simulate ischemia. +other 31164797 hsa-mir-326 Uterine Cervical Neoplasms MTT, colony formation, wound-healing, transwell and flow cytometer assay detected the influence of TDRG1 and miR-326 on CC cells growth, metastasis and apoptosis. CONCLUSION: TDRG1 acts as a competing endogenous lncRNA (ceRNA) to modulate MAPK1 by sponging miR-326 in CC, shedding new light on TDRG1-directed diagnostics and therapeutics in CC. +genetics_knock down_promote 31164635 hsa-mir-28 Pulmonary Fibrosis Collectively, the results showed that M2 macrophage-derived exosomes overexpressing miR-328 aggravate PF through the regulation of FAM13A. +other 31164416 hsa-let-7 Alzheimer Disease In many heterochronic mutants, presynapses of this cholinergic motoneuron are mislocalized to the dendrite at the ventral side: inactivation of the blmp-1 transcription factor gene, the lin-29/Zn finger transcription factor, lin-28/RNA binding protein, and the let-7miRNA gene all disrupt the presynaptic polarity of this DA cholinergic neuron. +other 31164416 hsa-let-7m Alzheimer Disease In many heterochronic mutants, presynapses of this cholinergic motoneuron are mislocalized to the dendrite at the ventral side: inactivation of the blmp-1 transcription factor gene, the lin-29/Zn finger transcription factor, lin-28/RNA binding protein, and the let-7miRNA gene all disrupt the presynaptic polarity of this DA cholinergic neuron. +transcription factor target 31164411 hsa-mir-224 Esophageal Squamous Cell Carcinoma Further study of UGT2B17 and MIR224, which are differentially dysregulated in ESCC and EA tumors, is warranted. +genetics_overexpression_promote 31164410 hsa-mir-9 Carcinoma, Hepatocellular 3p overexpression resulted in decreased migration and invasion rates of HCC cells. +genetics_overexpression_promote 31164163 hsa-mir-423 Lung Neoplasms Results of functional analyses revealed that overexpression of miR +lncRNA target 31164009 hsa-mir-145 Sleep Apnea, Obstructive In conclusion, lncRNA ROR alleviated CoCl(2)-induced hypoxia injury through regulation of miR-145 as well as modulating ERK and MAPK signalling. +lncRNA target 31163553 hsa-mir-206 Laryngeal Neoplasms Conclusion: FOXD2-AS1 is corelated with clinicopathological parameter of laryngeal squamous cell carcinoma and promotes cancer cell proliferation through targeting miR-206. +circulation_biomarker_diagnosis_ns 31163428 hsa-mir-886 Multiple Myeloma 5p triggered MM cell growth and may act as a diagnostic plasma biomarker for MM, potentially contributing to resistance to chemotherapy. +exosome 31163320 hsa-mir-24 Retinopathy of Prematurity 3p) levels were extremely high in exosomes from microglial cells, suggesting that this could be the key molecule that inhibits the hypoxia-induced expression of IRE1alpha in photoreceptors. +other 31163263 hsa-mir-429 Pancreatic Carcinoma We identified the critical axis of XIST/miR-429/ZEB1 in PC cell migration, invasion and EMT, which may aid in developing new therapeutic strategies for PC. +genetics_GWAS 31163195 hsa-mir-16 Carcinoma, Hepatocellular One compound, sanguinarine (SG), was capable of activating miR-16 in HCC cells with wildtype or mutated p53 expression but not in p53-deleted HCC cells. +other 31163194 hsa-mir-205 Ovarian Neoplasms Representative members of the miR-200 family of miRNAs and the sequence divergent miR-205 miRNA were independently over expressed in mesenchymal-like ovarian cancer (OC) cells resulting in mesenchymal-to-epithelial transition (MET). The miR-205 and the miR-200 family of miRNAs were found to coordinately induce MET in mesenchymal-like OC cells by affecting both direct and indirect changes in the expression of genes previously associated with EMT/MET. +circulation_biomarker_diagnosis_up 31163082 hsa-mir-21 Lupus Erythematosus, Systemic CONCLUSIONS: Our meta-analysis demonstrated that circulating miRNAs might be potential novel biomarkers for detecting SLE, especially miR-21. +genetics_overexpression_suppress 31163018 hsa-mir-650 Carcinoma, Hepatocellular Rescue experiment demonstrated that NAFSC overexpression could partially counteracted the inhibitory effect of miR-3650 in HCC metastasis and EMT. +genetics_overexpression_promote 31162914 hsa-mir-451a Carcinoma, Hepatocellular We further confirmed that overexpression of miR-451a functions in HCC and endothelia cells in vitro and in vivo. +genetics_overexpression_promote 31162869 hsa-mir-29a Cardiomegaly CONCLUSION: In pathological cardiac hypertrophy, miR-29a was overexpressed and promoted cardiac hypertrophy by regulating the PTEN/AKT/mTOR pathway and suppressing autophagy. +genetics_overexpression_promote 31162869 hsa-mir-29 Cardiomegaly CONCLUSION: In pathological cardiac hypertrophy, miR-29a was overexpressed and promoted cardiac hypertrophy by regulating the PTEN/AKT/mTOR pathway and suppressing autophagy. +circulation_biomarker_diagnosis_up 31162867 hsa-mir-92b Carcinoma, Hepatocellular Furthermore, higher expression of miR-92b in serum exosomes was confirmed in HCC patients before LDLT, and its value at 1 month after LDLT was maintained at a higher level in the patients with posttransplant HCC recurrence. +genetics_GWAS 31162799 hsa-mir-1275 Glioblastoma In summary, our study shows that epigenetic inhibition of miR-1275 by the cAMP/PKA/PRC2/H3K27me3 pathway mediates glial induction of GBM cells, providing a new mechanism and novel targets for differentiation-inducing therapy. +other 31162779 hsa-mir-1 Colorectal Neoplasms Notably, the expression levels of miR-31 were positively correlated with the grade of clinical stages of colorectal tumors. This study provides evidence supporting the association of miR-31 with 5-FU drug resistance and clinical stages of colorectal tumors. +epigenetics 31162777 hsa-mir-369 Stomach Neoplasms Overall, our findings provide convincing evidence that both the 5p and 3p arms of miRNA co-expressed in GC and DNA methylation-induced miR-369 signaling contribute to GC progression. +other 31162747 hsa-mir-155 Corneal dystrophy, epithelial basement membrane Overall, the identification of the CagA/miR-155/KLF4 signaling pathway provided a new insight into the development and treatment of GC. +genetics_overexpression_promote 31162714 hsa-mir-374c Breast Neoplasms We uncovered that overexpressed miR-374c-5p inhibited the development of breast cancer via TAF7-regulated transcriptional regulation of DEPDC1, which may be a novel and vital proportion of cancer diagnosis and treatment strategies. +genetics_overexpression_promote 31162712 hsa-mir-10b Urinary Bladder Neoplasms TUC338 and miR-10b overexpression significantly promoted bladder cancer cell invasion and migration. +circulation_biomarker_diagnosis_ns 31162549 hsa-mir-21 Kidney Diseases Circulating miRNAs (miRs) related to heart failure (miR30e-5p, miR199a-3p), endothelial dysfunction (miR27b and miR200b), and renal function (miR130b-3p, miR21-5p) were assessed and related to the effects of treatments. +circulation_biomarker_diagnosis_ns 31162549 hsa-mir-130b Heart Failure Circulating miRNAs (miRs) related to heart failure (miR30e-5p, miR199a-3p), endothelial dysfunction (miR27b and miR200b), and renal function (miR130b-3p, miR21-5p) were assessed and related to the effects of treatments. +circulation_biomarker_diagnosis_ns 31162549 hsa-mir-27b Kidney Diseases Circulating miRNAs (miRs) related to heart failure (miR30e-5p, miR199a-3p), endothelial dysfunction (miR27b and miR200b), and renal function (miR130b-3p, miR21-5p) were assessed and related to the effects of treatments. +circulation_biomarker_diagnosis_ns 31162549 hsa-mir-21 Heart Failure Circulating miRNAs (miRs) related to heart failure (miR30e-5p, miR199a-3p), endothelial dysfunction (miR27b and miR200b), and renal function (miR130b-3p, miR21-5p) were assessed and related to the effects of treatments. +circulation_biomarker_diagnosis_ns 31162549 hsa-mir-21 Pituitary Diseases Circulating miRNAs (miRs) related to heart failure (miR30e-5p, miR199a-3p), endothelial dysfunction (miR27b and miR200b), and renal function (miR130b-3p, miR21-5p) were assessed and related to the effects of treatments. +circulation_biomarker_diagnosis_ns 31162549 hsa-mir-130b Kidney Diseases Circulating miRNAs (miRs) related to heart failure (miR30e-5p, miR199a-3p), endothelial dysfunction (miR27b and miR200b), and renal function (miR130b-3p, miR21-5p) were assessed and related to the effects of treatments. +circulation_biomarker_diagnosis_ns 31162549 hsa-mir-27b Pituitary Diseases Circulating miRNAs (miRs) related to heart failure (miR30e-5p, miR199a-3p), endothelial dysfunction (miR27b and miR200b), and renal function (miR130b-3p, miR21-5p) were assessed and related to the effects of treatments. +circulation_biomarker_diagnosis_ns 31162549 hsa-mir-200b Heart Failure Circulating miRNAs (miRs) related to heart failure (miR30e-5p, miR199a-3p), endothelial dysfunction (miR27b and miR200b), and renal function (miR130b-3p, miR21-5p) were assessed and related to the effects of treatments. +circulation_biomarker_diagnosis_ns 31162549 hsa-mir-27b Heart Failure Circulating miRNAs (miRs) related to heart failure (miR30e-5p, miR199a-3p), endothelial dysfunction (miR27b and miR200b), and renal function (miR130b-3p, miR21-5p) were assessed and related to the effects of treatments. +circulation_biomarker_diagnosis_ns 31162549 hsa-mir-200b Kidney Diseases Circulating miRNAs (miRs) related to heart failure (miR30e-5p, miR199a-3p), endothelial dysfunction (miR27b and miR200b), and renal function (miR130b-3p, miR21-5p) were assessed and related to the effects of treatments. +circulation_biomarker_diagnosis_ns 31162549 hsa-mir-130b Pituitary Diseases Circulating miRNAs (miRs) related to heart failure (miR30e-5p, miR199a-3p), endothelial dysfunction (miR27b and miR200b), and renal function (miR130b-3p, miR21-5p) were assessed and related to the effects of treatments. +circulation_biomarker_diagnosis_ns 31162549 hsa-mir-200b Pituitary Diseases Circulating miRNAs (miRs) related to heart failure (miR30e-5p, miR199a-3p), endothelial dysfunction (miR27b and miR200b), and renal function (miR130b-3p, miR21-5p) were assessed and related to the effects of treatments. +circulation_biomarker_diagnosis_ns 31162549 hsa-mir-199a Heart Failure Circulating miRNAs (miRs) related to heart failure (miR30e-5p, miR199a-3p), endothelial dysfunction (miR27b and miR200b), and renal function (miR130b-3p, miR21-5p) were assessed and related to the effects of treatments. +circulation_biomarker_diagnosis_ns 31162549 hsa-mir-199a Kidney Diseases Circulating miRNAs (miRs) related to heart failure (miR30e-5p, miR199a-3p), endothelial dysfunction (miR27b and miR200b), and renal function (miR130b-3p, miR21-5p) were assessed and related to the effects of treatments. +circulation_biomarker_diagnosis_ns 31162549 hsa-mir-199a Pituitary Diseases Circulating miRNAs (miRs) related to heart failure (miR30e-5p, miR199a-3p), endothelial dysfunction (miR27b and miR200b), and renal function (miR130b-3p, miR21-5p) were assessed and related to the effects of treatments. +lncRNA target 31162548 hsa-mir-137 Prolactinoma CONCLUSIONS: Our data suggest that miR-137 possesses a tumor invasive suppressor function with a prognostic value in prolactinomas by targeting MITF and modulating Wnt-beta-catenin signaling pathway. +lncRNA target 31161659 hsa-mir-21 Neuralgia A significant alleviated neuropathic pain development and reduced the expression of cytokines was observed in CCI rat after exogenous injection of miR +genetics_knock down_promote 31161625 hsa-mir-155 Pancreatic Carcinoma In addition, we exhibited that silence of MIR155HG by short hairpin RNA knockdown significantly inhibited cell growth and promoted cell apoptosis in PC cells. +genetics_overexpression_suppress 31161607 hsa-mir-219a Ovarian Neoplasms It was indicated that underexpressed MEG3 and miR-219a-5p were significantly associated with unfavorable prognosis of patients with OC when compared with overexpressed MEG3 and miR-219a-5p (P < .05). +other 31161417 hsa-mir-150 Lymphoma, Non-Hodgkin CONCLUSIONS: miR5p is involved in B cell receptor pathways and let-7b-5p plays a role in the innate immune response processes that are potentially important in the etiology of non-Hodgkin lymphoma (NHL). +other 31161417 hsa-let-7b Lymphoma, Non-Hodgkin CONCLUSIONS: miR5p is involved in B cell receptor pathways and let-7b-5p plays a role in the innate immune response processes that are potentially important in the etiology of non-Hodgkin lymphoma (NHL). +genetics_overexpression_promote 31161410 hsa-mir-21 Thyroid Cancer, Papillary Overexpression of miR-21 predicted poor prognosis in PTC. +lncRNA target 31161373 hsa-mir-214 Carcinoma, Endometrioid Suppression of miR-214 abolished the effects of si-DANCR on cell proliferation and apoptosis in AN3CA and HEC-1B cells. +genetics_knock down_promote 31161266 hsa-mir-361 Retinoblastoma CONCLUSION: These results indicated that overexpression of miR +transcription factor target 31160967 hsa-mir-21 Spinal muscular atrophy with respiratory distress 1 Targeting miR-21 is implicated as a novel therapeutic strategy for the prevention of RIPF. +other 31160967 hsa-mir-21 Pulmonary Fibrosis This included miR-21, which has been reported to contribute to the pulmonary fibrotic response induced by stereotactic body radiotherapy. +genetics_overexpression_suppress 31160893 hsa-mir-340 Carcinoma, Non-Small-Cell Lung Overexpression of miR +lncRNA target 31160577 hsa-mir-145 Thyroid Cancer, Papillary In conclusion, we validated n384546 as a novel oncogenic lncRNA in PTC and determined that the n384546/miR5p/AKT3 pathway contributes to PTC progression, which might be used as potential therapeutic targets for PTC patients. +other 31160576 hsa-mir-138 Carcinoma, Non-Small-Cell Lung 5p expression was negatively correlated with TRIM65 mRNA in NSCLC tissues. +transcription factor target 31160483 hsa-mir-505 Carcinoma, Hepatocellular Collectively, our results demonstrated the tumor suppressive function of miR-505 possibly via inhibiting the glycolysis of HCC cells. +lncRNA target 31160270 hsa-mir-96 Carcinoma, Non-Small-Cell Lung 5p/RASSF8/E-cadherin axis dysregulation in NSCLC tumor progression. +lncRNA target 31160087 hsa-mir-17 Siderosis 92 protects endothelial cells from erastin-induced ferroptosis by targeting the A20-ACSL4 axis. +transcription factor target 31159863 hsa-mir-449a Arthritis, Rheumatoid RESULTS: MiR-449a was downregulated in RA synovial tissue and inhibited RA-FLS proliferation, migration, and IL-6 production. +other 31159706 hsa-mir-216a Colonic Neoplasms Additionally, univariate and multivariate Cox regression analyses showed that the microRNA-216a of the competing endogenous RNA might be an independent prognostic factor in colon cancer. +other 31159652 hsa-mir-208b Myocardial Infarction After transcoronary ablation of septal hypertrophy, muscle-enriched miRNAs (miR-1 and miR-133a) showed a steeper and earlier increase than cardiac-enriched miRNAs (miR-499 and miR-208b). +other 31159652 hsa-mir-1 Myocardial Infarction After transcoronary ablation of septal hypertrophy, muscle-enriched miRNAs (miR-1 and miR-133a) showed a steeper and earlier increase than cardiac-enriched miRNAs (miR-499 and miR-208b). +other 31159652 hsa-mir-499 Myocardial Infarction After transcoronary ablation of septal hypertrophy, muscle-enriched miRNAs (miR-1 and miR-133a) showed a steeper and earlier increase than cardiac-enriched miRNAs (miR-499 and miR-208b). +other 31159652 hsa-mir-133a Myocardial Infarction After transcoronary ablation of septal hypertrophy, muscle-enriched miRNAs (miR-1 and miR-133a) showed a steeper and earlier increase than cardiac-enriched miRNAs (miR-499 and miR-208b). +other 31159615 hsa-mir-29a Breast Neoplasms In this study, we designed dextran-coated iron oxide-based nanoparticle for the delivery of miR-29a to breast cancer cells and analyzed its therapeutic efficacy in vitro. These results pave the way for further investigations into the possible use of miR-29a complex magnetic nanoparticles for breast cancer therapy. +lncRNA target 31159158 hsa-mir-150 Leiomyoma After transfecting cultured leiomyoma cells with the miR-150 mimic, expression levels of its target gene Akt decreased, whereas those of p27(Kip1) increased significantly. +epigenetics 31158449 hsa-mir-9 Carcinoma, Non-Small-Cell Lung Our study demonstrated that microRNA-9 enhanced radiosensitivity in NSCLC and this effect is highly regulated by its promoter methylation status. +tissue_expression_up 31158447 hsa-mir-205 Nasopharyngeal Carcinoma In this study, we manifested firstly that the expression of miR +other 31158382 hsa-mir-34a Cataract In addition, the expression level of miR-34a was downregulated, whereas that of Notch1 was upregulated in capsular opacification from cataract samples. +other 31158382 hsa-mir-34a Polycystic Ovary Syndrome Therefore, miR-34a/Notch1 could serve as a potential therapeutic approach for the treatment of PCO. +lncRNA target 31158376 hsa-mir-23a Diabetic Foot CONCLUSION: Rg1 promoted angiogenesis in diabetic wound healing process through NO signaling via miR-23a, providing a novel candidate for DFUs treatment. +other 31157926 hsa-mir-98 Urinary Bladder, Overactive 5p was significantly downregulated in patients with OAB and no correlation was determined between the levels of miRNAs with OAB symptom score. +other 31157926 hsa-mir-139 Urinary Bladder, Overactive 5p was significantly downregulated in patients with OAB and no correlation was determined between the levels of miRNAs with OAB symptom score. +other 31157926 hsa-mir-92a Urinary Bladder, Overactive 5p was significantly downregulated in patients with OAB and no correlation was determined between the levels of miRNAs with OAB symptom score. +other 31157926 hsa-mir-142 Urinary Bladder, Overactive 5p was significantly downregulated in patients with OAB and no correlation was determined between the levels of miRNAs with OAB symptom score. +other 31157926 hsa-let-7b Urinary Bladder, Overactive 5p was significantly downregulated in patients with OAB and no correlation was determined between the levels of miRNAs with OAB symptom score. +other 31157926 hsa-mir-200c Urinary Bladder, Overactive 5p was significantly downregulated in patients with OAB and no correlation was determined between the levels of miRNAs with OAB symptom score. +lncRNA target 31157375 hsa-mir-484 Carcinoma, Hepatocellular In conclusion, miR-484/TUSC5 is potential diagnostic biomarkers and therapy targets for HCC. +genetics_overexpression_promote 31157262 hsa-mir-200c Prostatic Neoplasms Overexpression of miR-200c-3p was considered a tumor suppressor and was found to significantly suppress the formation of migration and invasion in PCa cells via repression of E-cadherin-induced EMT. +genetics_GWAS 31157259 hsa-let-7 Burkitt Lymphoma related mirSNPs could predict pathologic complete response to taxane- and platinum-based neoadjuvant chemotherapy in LABC, which suggests the potential role of variants of miRNA let +genetics_GWAS 31157259 hsa-let-7 Bulimia Nervosa related mirSNPs could predict pathologic complete response to taxane- and platinum-based neoadjuvant chemotherapy in LABC, which suggests the potential role of variants of miRNA let +genetics_GWAS 31157259 hsa-let-7 Breast Neoplasms This study aims to evaluate the potential role of let-7 miRNA-related single nucleotide polymorphisms (mirSNPs) in the prediction of pathologic complete response to taxane- and platinum-based neoadjuvant chemotherapy in locally advanced breast cancer (LABC). +other 31157242 hsa-mir-1 Fibrosis We identified that miRNA-1 is expressed in cardiac fibroblasts, which are one of the major non-muscle cell types in myocardium and are responsible for cardiac fibrosis in pathological conditions. +lncRNA target 31157168 hsa-mir-141 Carcinoma, Hepatocellular 3p, and target genes revealed that RHEB, a key regulator in mTOR signaling pathway, was the target of miR +other 31156641 hsa-mir-146b Severe Fever with Thrombocytopenia Syndrome We also found that SFTSV increased endogenous miR-146b-induced differentiation of macrophages into M2 cells mediated by viral non-structural protein (NSs). +transcription factor target 31155965 hsa-mir-29a Scleroderma, Systemic Focusing on miR-21 and miR-29s as therapeutic targets would be effective in patients with SSc or other fibrotic diseases which show aberrant expression of collagen expression. +transcription factor target 31155965 hsa-mir-21 Scleroderma, Systemic Focusing on miR-21 and miR-29s as therapeutic targets would be effective in patients with SSc or other fibrotic diseases which show aberrant expression of collagen expression. +lncRNA target 31155864 hsa-mir-664 Brain Ischemia CONCLUSION: EA of GV20 and GV24 can improve the learning-memory ability of CI/RI rats, which is closely related to its effect in down-regulating the levels of hippocampal target genes of miR +transcription factor target 31155753 hsa-mir-122 Breast Neoplasms 5p is involved in the pathway of cell-cycle arrest by targeting Bcl-2 and CDKs. +lncRNA target 31155482 hsa-mir-17 Amyotrophic Lateral Sclerosis Thus, mir-17 approximately 92 may have value as a prognostic marker of MN degeneration and is a candidate therapeutic target in SOD1-linked ALS. +lncRNA target 31154456 hsa-mir-466 Intrauterine Adhesion CONCLUSIONS Our data suggest that miR-466 and NUS1 regulate proliferation and the EMT process through the AKT/NFkappaB pathway in IUAs in a rat model. +other 31153886 hsa-mir-204 Cataract 5p and play a role in the pathogenesis of DC. +other 31153869 hsa-mir-126 Glaucoma, Open-Angle POAG-patient tear pellets showed elevated concentrations of genomic ds-DNA and SINE-repeats, and different expressions of miR-146b, miR-16 and miR-126 and a different set of bacterial DNA in comparison with pellets obtained from the tears of HPs. +other 31153869 hsa-mir-146b Glaucoma, Open-Angle POAG-patient tear pellets showed elevated concentrations of genomic ds-DNA and SINE-repeats, and different expressions of miR-146b, miR-16 and miR-126 and a different set of bacterial DNA in comparison with pellets obtained from the tears of HPs. +other 31153869 hsa-mir-16 Glaucoma, Open-Angle POAG-patient tear pellets showed elevated concentrations of genomic ds-DNA and SINE-repeats, and different expressions of miR-146b, miR-16 and miR-126 and a different set of bacterial DNA in comparison with pellets obtained from the tears of HPs. +lncRNA target 31153780 hsa-mir-340 Pancreatic Carcinoma CONCLUSION: Altogether, these findings indicated that miR-340 exerted suppressor on cell growth by targeting BICD2 in pancreatic cancer and miR-340/BICD2 axis could be used as a candidate target to treat pancreatic cancer. +other 31153639 hsa-mir-488 Carcinoma, Non-Small-Cell Lung Circular RNA circ_0020123 promotes non-small cell lung cancer progression by acting as a ceRNA for miR3p to regulate ADAM9 expression. +exosome 31153637 hsa-mir-27a Prostatic Neoplasms In the present study, we aimed to construct potential regulatory networks of exosomal miR-27a in PCa chemoresistance. +exosome 31153636 hsa-mir-29a Obesity Taken together, these findings suggest that ATMs derived exosomal miR-29a could regulate obesity-associated insulin resistance, which may serve as a potential therapeutic target for obesity-associated type 2 diabetes. +exosome 31153636 hsa-mir-29a Diabetes Mellitus, Type 2 Taken together, these findings suggest that ATMs derived exosomal miR-29a could regulate obesity-associated insulin resistance, which may serve as a potential therapeutic target for obesity-associated type 2 diabetes. +circulation_biomarker_diagnosis_ns 31153517 hsa-mir-125b Tuberculosis Taqman based qRT-PCR analysis of host-genome encoded (hsa-miR-146a-5p and hsa-miR-125b-5p) and MTB genome encoded (MTB-miR5) miRNAs showed increased expression in a cohort of 52 healthy, pulmonary tuberculosis (PTB) and extra pulmonary tuberculosis (EPTB) patients serum samples. +circulation_biomarker_diagnosis_ns 31153517 hsa-mir-146a Tuberculosis Taqman based qRT-PCR analysis of host-genome encoded (hsa-miR-146a-5p and hsa-miR-125b-5p) and MTB genome encoded (MTB-miR5) miRNAs showed increased expression in a cohort of 52 healthy, pulmonary tuberculosis (PTB) and extra pulmonary tuberculosis (EPTB) patients serum samples. +lncRNA target 31153371 hsa-mir-191 Carcinoma, Hepatocellular Circular RNA circTRIM33-12 acts as the sponge of MicroRNA-191 to suppress hepatocellular carcinoma progression. Mechanistically, we demonstrated that circTRIM33-12 upregulated TET1 expression by sponging miR-191, resulting in significantly reduced 5-hydroxymethylcytosine (5hmC) levels in HCC cells. +other 31152930 hsa-mir-663 Colorectal Neoplasms In the present study, we revealed that SNHG8 was up-regulated in colorectal cancer and promoted the proliferation, migration, and invasion of colorectal cancer by sponging miR-663, which helps to further reveal the underlying developmental mechanism of action and provides a potential therapeutic molecule for colorectal cancer therapy in the future. +other 31152707 hsa-mir-130a Leukemia, Myeloid, Acute miR-130a is over-expressed in AML. The data obtained in this study highlight that the correct modulation of miR-130a is necessary for normal differentiation to occur and confirming that deregulation of this miRNA might underlie the differentiation block occurring in AML. +genetics_overexpression_promote 31152622 hsa-mir-181a Laryngeal Neoplasms Their opposing functions are further supported by the findings (a) that miR-181a is down-regulated, while NPM1 is up-regulated in laryngeal cancer, and (b) that either inhibition of miR-181a or overexpression of NPM1 can revert the pro-apoptotic effects of MYCT1 on laryngeal cancer cells through extracellular and intracellular apoptotic pathways. +other 31152485 hsa-mir-133a Arrhythmias, Cardiac MiR-133a/b mimics may reverse signalling of ZFHX3 KD-mediated cardiac remodelling and atrial arrhythmia. +lncRNA target 31152456 hsa-mir-377 Osteosarcoma Taken together, our results conclude that miR-377 may promote OS cell apoptosis through inactivation of the HAT1-mediated Wnt signaling pathway, highlighting the potential therapeutic effect of miR-377 on OS treatment. +other 31152438 hsa-let-7g Glucose-Galactose Malabsorption Moreover, KRAS mRNA/protein only showed slight reduction when GG-genotyped primary thyroid cancer cells were transfected by let-7g precursors. Additionally, let-7g precursors exhibited no significant effect on cell proliferation index or cell apoptosis in GG cells. +other 31152438 hsa-let-7g Thyroid Neoplasms In addition, the mRNA/protein level of KRAS as well as cell proliferation index was decreased in primary thyroid cancer cells genotyped as TT/TG and transfected with KRAS small interfering RNA (siRNA)/let-7g precursors. Moreover, KRAS mRNA/protein only showed slight reduction when GG-genotyped primary thyroid cancer cells were transfected by let-7g precursors. +genetics_GWAS 31152438 hsa-let-7g Trigeminal Neuralgia Rs712 polymorphism T>G in the 3'-untranslated region of KRAS interrupts the interactions between let-7g and KRAS mRNA, leading to a higher cell proliferation index and reduced doubling time of TN. +lncRNA target 31152340 hsa-mir-134 Hyperphagia These results indicated that dlStr miR-134, perhaps via its target LIMK1, contributed to excessive and uncontrolled methamphetamine intake, supporting the hypothesis that stimulus-response habit formation is an important mechanism underlying the transition from controlled drug use to uncontrolled drug use and addiction. +transcription factor target 31152340 hsa-mir-134 Substance-Related Disorders These results indicated that dlStr miR-134, perhaps via its target LIMK1, contributed to excessive and uncontrolled methamphetamine intake, supporting the hypothesis that stimulus-response habit formation is an important mechanism underlying the transition from controlled drug use to uncontrolled drug use and addiction. +lncRNA target 31152315 hsa-mir-873 Colorectal Neoplasms 5p suppressed carcinogenesis by targeting JMJD8 in CRC. +circulation_biomarker_diagnosis_down 31152142 hsa-mir-337 Leukemia, Lymphocytic, Chronic, B-Cell Here, we observed hsa_circ_0132266 (circ_0132266), a circRNA significantly decreased in the peripheral blood mononuclear cells (PBMCs) of CLL patients compared with healthy donors, could act as an endogenous sponge of hsa-miR +other 31151766 hsa-mir-133a Cerebrovascular Disorders 5p. +other 31151766 hsa-mir-29a Cerebrovascular Disorders 5p, miR-20b-5p, and miR-29a-3p. +other 31151766 hsa-mir-125b Cerebrovascular Disorders 5p. +other 31151766 hsa-mir-20b Cerebrovascular Disorders 5p, miR-20b-5p, and miR-29a-3p. +other 31151766 hsa-mir-145 Cerebrovascular Disorders 5p. +other 31151766 hsa-mir-100 Cerebrovascular Disorders 5p. +lncRNA target 31150989 hsa-mir-193a Carcinoma, Non-Small-Cell Lung Our findings suggested that STAT3-induced LINC00668 contributed to NSCLC progression through upregulating KLF7 expression by sponging miR-193a, and may serve as a prognostic biomarker and a potential target for NSCLC. +genetics_overexpression_promote 31150929 hsa-mir-455 Liver Cirrhosis The overexpression of miR +circulation_biomarker_diagnosis_ns 31150916 hsa-mir-375 Obesity Circulating miR-375 levels were significantly lower (P=.012) in women with MetS. +circulation_biomarker_diagnosis_ns 31150916 hsa-mir-584 Obesity In conclusion, our findings suggested that a daily intake of 1 Brazil nut increased circulating miR +circulation_biomarker_diagnosis_ns 31150916 hsa-mir-454 Obesity In conclusion, our findings suggested that a daily intake of 1 Brazil nut increased circulating miR +circulation_biomarker_diagnosis_ns 31150847 hsa-mir-451 Stroke RESULTS: The results showed that miR-451 levels in the circulating blood of ischemic stroke patients were greatly decreased compared with the control. +circulation_biomarker_diagnosis_ns 31150847 hsa-mir-451 Reperfusion Injury, Cerebral Ischemia RESULTS: The results showed that miR-451 levels in the circulating blood of ischemic stroke patients were greatly decreased compared with the control. +circulation_biomarker_diagnosis_ns 31150734 hsa-mir-22 Reperfusion Injury Co-injection of FBXW7 plasmid with mimic-miR322 in ischemic hearts abolished the effect of mimic-miR322 to reduce apoptosis and infarct size in MI/R hearts. +circulation_biomarker_diagnosis_up 31150684 hsa-mir-145 Ischemic Stroke The expression of miR-145 was significantly upregulated in the blood of patients with ischemic stroke compared to that of normal controls. +other 31150646 hsa-mir-205 Stomach Neoplasms Nevertheless, miR-205 did not show any significant results in correlation with EMT in AGS cell line. +lncRNA target 31150646 hsa-mir-200a Stomach Neoplasms Therefore, in further investigation, miR-200a could be used as a candidate to prevent the invasive properties of gastric cancer through the EMT process. +circulation_biomarker_diagnosis_up 31150454 hsa-mir-221 Cardiovascular Diseases Effect of radiotherapy on the expression of cardiovascular disease-related miRNA-146a, -155, -221 and -222 in blood of women with breast cancer. Previous studies have supported a role for miRNA-146a, -155, -221, and -222 in the progression of CVD. +circulation_biomarker_diagnosis_up 31150454 hsa-mir-146a Cardiovascular Diseases Effect of radiotherapy on the expression of cardiovascular disease-related miRNA-146a, -155, -221 and -222 in blood of women with breast cancer. Previous studies have supported a role for miRNA-146a, -155, -221, and -222 in the progression of CVD. +circulation_biomarker_diagnosis_up 31150454 hsa-mir-221 Breast Neoplasms Effect of radiotherapy on the expression of cardiovascular disease-related miRNA-146a, -155, -221 and -222 in blood of women with breast cancer. Previous studies have supported a role for miRNA-146a, -155, -221, and -222 in the progression of CVD. +circulation_biomarker_diagnosis_up 31150454 hsa-mir-146a Breast Neoplasms Effect of radiotherapy on the expression of cardiovascular disease-related miRNA-146a, -155, -221 and -222 in blood of women with breast cancer. Previous studies have supported a role for miRNA-146a, -155, -221, and -222 in the progression of CVD. +other 31150430 hsa-mir-216a Carcinoma, Pancreatic Ductal miR-216 family (miR-216a-3p, miR-216a-5p, miR-216b-3p and miR-216b-5p) was consistently down-regulated in PDAC. +other 31150430 hsa-mir-216b Carcinoma, Pancreatic Ductal miR-216 family (miR-216a-3p, miR-216a-5p, miR-216b-3p and miR-216b-5p) was consistently down-regulated in PDAC. +lncRNA target 31150368 hsa-mir-96 Spinal Cord Injuries RESULTS: Triptolide promoted locomotion recovery of SCI rats, upregulated the expression of miR-96, decreased microglia activation marker Iba-1 and IKKbeta/NF-kappaB-related proteins, and inhibited inflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta levels in spinal cord tissues and lipopolysaccharide -induced microglia. CONCLUSION: Triptolide suppressed microglia activation after SCI through miR-96/IKKbeta/NF-kappaB pathway. +genetics_overexpression_suppress 31150156 hsa-let-7a Osteosarcoma Overexpression of let-7a inhibits osteosarcoma cell proliferation, which was reversed by CBX2 overexpression. Taken together, our study demonstrates that let-7a/CBX2 plays a crucial role in osteosarcoma progression. +other 31149251 hsa-mir-34a Obesity CONCLUSIONS: miR-34a is associated with insulin and HOMA-IR and thus seems to be involved in IR. +other 31149251 hsa-mir-149 Obesity OBJECTIVE: The aim of this study was to evaluate the levels of miR-34a and miR-149 and their relationship with metabolic parameters in obese children and adolescents. There was no significant difference in miR-34a and miR-149 between obese and normal weight subjects. +genetics_GWAS 31149197 hsa-mir-483 Adrenocortical Carcinoma In this field of research, epigenetic studies identified a common signature in ACC, where the most altered miRNA found in ACC (miR5p) seems now to represent a concrete biomarker to be used in the pre-operative diagnosis of ACC. +other 31149186 hsa-mir-126 Diabetes Mellitus Also, simultaneous treatment of castrated diabetic rats with testosterone and exercise had an additive effect on miRNA-126 expression levels. +other 31149077 hsa-mir-29 Osteoporosis The aims of the present study were to evaluate the effects of swimming training on cardiac histology and expression of miR-29 and IGF-1 in the ovariectomized rats. Exercise training increased miR-29 and IGF-1 expression in the trained rats and improved histology and lipid profile compared with OVX group (p<0.05). +transcription factor target 31149077 hsa-mir-29 Deficiency Diseases CONCLUSION: Estrogen deficiency could lead to cardiac fibrosis through deregulation miR-29 and IGF-1 expression. +transcription factor target 31149077 hsa-mir-29 Cardiomyopathies CONCLUSION: Estrogen deficiency could lead to cardiac fibrosis through deregulation miR-29 and IGF-1 expression. +circulation_biomarker_diagnosis_ns 31148365 hsa-mir-17 Liver Cirrhosis Taken together, we demonstrate that circMTO1 inhibits liver fibrosis via regulation of miR5p and Smad7, and serum circMTO1 may be a novel promising biomarker of liver fibrosis. +other 31148290 hsa-let-7a Asthma CONCLUSIONS AND CLINICAL RELEVANCE: Our data suggest that hsa_circ_0005519 may induce IL-13 and IL-6 expression by regulating hsa-let-7a-5p in CD4(+) T cells to affect asthma. +genetics_knock down_promote 31148248 hsa-mir-206 Renal Insufficiency, Chronic Moreover, to further determine the roles of both miR-206 and the JAK/STAT signaling pathway in CKD, the gain- and loss-of function approaches were performed with the expression of ANXA1, alpha-SMA, E-cadherin, vimentin, N-cadherin, and the JAK/STAT signaling pathway-related genes detected. +lncRNA target 31148243 hsa-mir-4319 Thyroid Neoplasms Collectively, the results of this study showed that miR-4319 inhibited the development of thyroid cancer by modulating FUS-stabilized SMURF1, indicating miR-4319 as a potent biological target for thyroid cancer. +transcription factor target 31148231 hsa-mir-199a Acute Kidney Injury In conclusion, our findings reveal that p53, upregulating the expression of miR-199a-3p affects the progress of cisplatin-induced AKI, which might provide a promising therapeutic target of AKI. +lncRNA target 31148230 hsa-mir-149 Pre-Eclampsia These findings indicate that ZEB2-AS1 contributes to PE progression by affecting cell proliferative and invasive capacities via the miR-149/PGF axis in HTR-8/SVneo cells. In sum, we identified that ZEB2-AS1 was a novel aberrantly expressed lncRNA in the placentas of PE patients and lncRNA ZEB2-AS1 modulated trophoblastic cell line HTR-8/SVneo's proliferative and invasive potentials via targeting the miR-149/PGF axis. +genetics_GWAS 31148212 hsa-mir-124 Fissure in Ano In addition, miR-124 polymorphism rs531564 is involved with the pathogenesis of anal abscess in AF patients, and the presence of rs531564 may increase the incidence of anal abscess via upregulating the expression of IL-6R, TNF-alpha, IFN-gamma, and IL-4. +other 31148190 hsa-mir-497 Acute Lung Injury The study aimed to investigate the mechanism of action of miR-497 in LPS-induced ALI. +lncRNA target 31147574 hsa-let-7 Sarcoma Our results highlight an important role for the LIN28B/LET-7 axis in human sarcoma pathogenesis and suggest that the therapeutic targeting of LIN28B may be relevant for patients with sarcoma. +lncRNA target 31147526 hsa-mir-335 Leukemia, Myeloid, Acute MiR-335/ID4 dysregulation facilitated leukemogenesis through the activation of PI3K/Akt signaling pathway. +lncRNA target 31147453 hsa-mir-373 Pancreatic Carcinoma QYHJ could effectivly enhance the antihuman pancreatic tumor activity of GEM, which may be through inhibiting pancreatic cancer stem cell differentiation by lncRNA AB209630/miR-373/EphB2-NANOG signaling pathway. +genetics_overexpression_promote 31147216 hsa-mir-511 Carcinoma, Hepatocellular Functionally, circZFR silencing or miR-511 overexpression suppressed cell proliferation, migration and invasion, and induced apoptosis of HCC cells. +lncRNA target 31147048 hsa-mir-149 Osteoarthritis 5p via polysaccharide based carriers could achieve collaborative impact in cartilage regeneration and have a potential to enhance osteoarthritis treatment. +genetics_overexpression_promote 31146975 hsa-mir-106a Stomach Neoplasms The promoting effect of miR-106a on gastric cancer invasion was significantly abolished by the overexpression of KLF4. +exosome 31146974 hsa-mir-17 Carcinoma, Non-Small-Cell Lung In conclusion, the newly developed diagnostic panel consisting of exosomal miR +other 31146527 hsa-mir-3 Lattice corneal dystrophy type 1 Of the three key LCBP components investigated, chlorogenic acid was found to activate SIRT1 and regulate the expression of the cholesterol-related factors ABCA1, SREBP2, and miR-33; cyanidinglucoside and catechins were effective to a lesser extent. +lncRNA target 31146345 hsa-mir-136 Breast Neoplasms We first focused on hsa-miR5p, an ERalpha36 3'UTR-targeting microRNA, the expression of which inversely correlated to the ERalpha36 one in breast cancer cells. +circulation_biomarker_diagnosis_ns 31146085 hsa-mir-210 Pheochromocytoma The aim of this study was to investigate if serum microRNA-210 (miR-210) levels could be a marker of malignancy in patients with PPGLs. CONCLUSIONS: In this pilot study, low serum miR-210 expression levels and large primary tumors were identified to be markers of PPGL malignancy on univariable analysis. +circulation_biomarker_diagnosis_ns 31146085 hsa-mir-210 Paraganglioma The aim of this study was to investigate if serum microRNA-210 (miR-210) levels could be a marker of malignancy in patients with PPGLs. CONCLUSIONS: In this pilot study, low serum miR-210 expression levels and large primary tumors were identified to be markers of PPGL malignancy on univariable analysis. +circulation_biomarker_diagnosis_ns 31146084 hsa-mir-4447 Attention Deficit Disorder with Hyperactivity In this study, peripheral blood expression levels of miR-5692b, miR-let-7d, miR3p, miR-4447 and miR-107 of 30 children and adolescents with combined type ADHD were compared to 30 healthy controls to understand the roles of these miRNAs in the ADHD etiopathogenesis. +circulation_biomarker_diagnosis_ns 31146084 hsa-mir-107 Attention Deficit Disorder with Hyperactivity In this study, peripheral blood expression levels of miR-5692b, miR-let-7d, miR3p, miR-4447 and miR-107 of 30 children and adolescents with combined type ADHD were compared to 30 healthy controls to understand the roles of these miRNAs in the ADHD etiopathogenesis. +circulation_biomarker_diagnosis_ns 31146084 hsa-mir-124 Attention Deficit Disorder with Hyperactivity In this study, peripheral blood expression levels of miR-5692b, miR-let-7d, miR3p, miR-4447 and miR-107 of 30 children and adolescents with combined type ADHD were compared to 30 healthy controls to understand the roles of these miRNAs in the ADHD etiopathogenesis. +genetics_overexpression_promote 31146014 hsa-mir-107 Osteoarthritis RESULTS: Overexpression of miR-107 suppressed HMGB-1 expression in OA chondrocytes. +other 31145943 hsa-mir-142 Cardiomyopathies Down-regulating TUG1 or up-regulating miR3p may ameliorate myocardial injury and protect against acute myocardial infarction. +lncRNA target 31145890 hsa-mir-621 Urinary Bladder Neoplasms Furthermore, we demonstrated that miR-621 inhibited the proliferation and metastasis of BCa cells via Wnt/beta-catenin signaling pathway by targeting TRIM29. +genetics_knock down_promote 31145886 hsa-mir-22 Carcinoma, Hepatocellular 3p expression in HCC cells, and knockdown of miR +other 31145301 hsa-let-7b Glioma Let-7b might be an independent prognostic biomarker for glioma (P<.001, HR=2.415; 95% CI: 1.531-3.808).Let-7b may be a promising prognostic factor in glioma. +circulation_biomarker_diagnosis_up 31145011 hsa-mir-27a Breast Neoplasms MATERIALS AND METHODS: MiR 27a expression was assessed in serum samples from patients with primary BC (n = 100), benign breast lesions (n = 30) and control group served as healthy volunteers (n = 20) using quantitative real-time PCR. +circulation_biomarker_diagnosis_ns 31144545 hsa-mir-29b Vascular Calcification CONCLUSIONS: Hemodialysis patients with vascular calcification had higher levels of miR 29a/b and miR223 than those without vascular calcification, and circulating miR29a was associated with calcification severity. +circulation_biomarker_diagnosis_ns 31144545 hsa-mir-29a Vascular Calcification CONCLUSIONS: Hemodialysis patients with vascular calcification had higher levels of miR 29a/b and miR223 than those without vascular calcification, and circulating miR29a was associated with calcification severity. +circulation_biomarker_diagnosis_ns 31144545 hsa-mir-223 Vascular Calcification CONCLUSIONS: Hemodialysis patients with vascular calcification had higher levels of miR 29a/b and miR223 than those without vascular calcification, and circulating miR29a was associated with calcification severity. +lncRNA target 31144533 hsa-mir-142 Periodontitis Based on these findings, we conclude that up-regulation of lncRNA FGD5-AS1 could protect against periodontitis via regulating the miR +lncRNA target 31144439 hsa-mir-32 Colorectal Neoplasms The ADAMTS9-AS2/miR-32/PHLPP2 regulatory axis may serve as a potential therapeutic target for CRC. +transcription factor target 31144434 hsa-mir-155 Epilepsy, Post-Traumatic Results suggest the role of miR-155 in regulating post-ischaemic seizures via PICs-GABA mechanisms. +transcription factor target 31144313 hsa-mir-382 Osteoarthritis, Knee miR3p has been reported to be upregulated in synovial membrane in knee osteoarthritis (OA). +lncRNA target 31144313 hsa-mir-382 Osteoarthritis 3p participated in OA may through the TLR4/MyD88/NF-kappaB signaling pathway by directly targeting CX43. +exosome 31144307 hsa-mir-146a Urethral Stricture Moreover, miR-146a-containing exosomes were taken up by fibroblasts and inhibited fibroblast activation and associated inflammatory responses, a finding that may underlie the therapeutic mechanism for suppression of urethral stricture. +genetics_GWAS 31144180 hsa-mir-124 Coronary Disease In this study, given that tetralogy of Fallot (TOF) is a CHD with hypoxemia as its primary pathophysiological manifestation, an in silico analysis was performed to reveal the relationship between potential target genes (miR-124) with the energy metabolism in non-syndromic TOF patients' cardiomyocyte. Furthermore, the study investigated the correlation between the primary miR-124 (rs531564) polymorphism and CHD susceptibility in 432 sporadic patients and 450 controls from two different altitude provinces (city) in China. +lncRNA target 31143973 hsa-mir-520c Pre-Eclampsia CONCLUSION: Collectively, miR-520c-3p could potentially inhibit NLRP3 inflammasome activation and inflammatory cascade in PE by downregulating NLRP3, highlighting the potential of miR-520c-3p as a therapeutic target for PE treatment. +other 31143920 hsa-mir-17 Pre-Eclampsia These results demonstrate SERS's specificity and sensitivity for a new biomarker (miRNA-17) that may ultimately be used in a detection platform for early diagnosis of preeclampsia. +other 31143769 hsa-mir-26a cataract 32 multiple types In addition, upregulation of MALAT1 and downregulation of miR-26a were detected in human posterior capsule opacification (PCO) attached LECs and the LECs obtained from patients with anterior polar cataracts by quantitative RT-PCR (qRT-PCR). +exosome 31143524 hsa-mir-146a Carcinoma, Hepatocellular In conclusion, identification of a role of the exosomal SALL4/miR-146a-5p regulatory axis in M2-polarization as well as HCC progression provides potential targets for therapeutic and diagnostic applications in liver cancer. +lncRNA target 31142732 hsa-mir-222 Carotid Artery Injuries Future studies are warranted to validate if the post-injury vascular neointimal hyperplasia and restenosis could be attenuated by inhibiting miR-222. +other 31141496 hsa-mir-498 Arthritis, Rheumatoid In this study, we analyzed how circFADS2 was regulated in LPS-treated chondrocytes and isolates from Rheumatoid arthritis (RA) patients and found that circFADS2 and mTOR were highly expressed whereas miR-498 expression was significantly reduced. +other 31141411 hsa-mir-1207 Stomach Neoplasms 5p and miR-1208 were upregulated in approximately 50% of GC tumors in relation to those of adjacent non-neoplastic tissues. +other 31141411 hsa-mir-1208 Stomach Neoplasms 5p and miR-1208 were upregulated in approximately 50% of GC tumors in relation to those of adjacent non-neoplastic tissues. +other 31141411 hsa-mir-1205 Stomach Neoplasms Aim: To analyze gene expression and copy number of five miRNAs (miR-1204, miR-1205, miR-1206, miR-1207 and miR-1208) localized in this chromosome region in gastric cancer (GC). Conclusion: The coexpression of the 8q24 miRNAs indicated the role of miR-1205 in the initiation of gastric cancer development. +lncRNA target 31141316 hsa-mir-125a Colorectal Neoplasms Several miRNAs have been found to be strongly correlated with the diagnosis, progression, and prognosis of colorectal carcinoma (CRC), but the role of miR-125a in CRC remains unclear. These results revealed that miR-125a plays a critical role in CRC by directly targeting Smurf1, a finding that may facilitate the development of improved diagnostic and therapeutic techniques for CRC. +circulation_biomarker_diagnosis_down 31141089 hsa-mir-3666 Diabetes Mellitus, Type 2 miR-3666 was significantly down-regulated in the serum of T2D patients when compared to that of healthy volunteers, and miR-3666 expression level was negatively correlated with blood glucose levels of T2D patients. +transcription factor target 31141015 hsa-mir-122 Liver Diseases MAP3K2 signaling pathway exerts an inhibitory effect in hepatitis B cells. +other 31140727 hsa-mir-638 Aortic Valve Disease Both miRNA microarray assay and qRT-PCR results demonstrating miR-638 was obviously up-regulated in calcific aortic valves compared with non-calcific valves. +other 31140727 hsa-mir-638 Nondisjunction, Genetic Both miRNA microarray assay and qRT-PCR results demonstrating miR-638 was obviously up-regulated in calcific aortic valves compared with non-calcific valves. +transcription factor target 31140727 hsa-mir-638 autosomal recessive congenital bilateral absence of vas deferens MiR-638 may be a potential therapeutic target for CAVD. +lncRNA target 31140612 hsa-mir-186 Carcinoma, Hepatocellular Our findings may provide new insight into the pathogenesis of HCC and miR-186/ MCRS1 might function as new therapeutic targets for HCC. +other 31140610 hsa-mir-199a Abnormalities, Multiple There is an increasing evidence that miR-199a-3p has a significant effect on the development of multiple tumors. +lncRNA target 31140417 hsa-mir-129 Stomach Neoplasms 5p is a potential therapeutic target for gastric cancer. +transcription factor target 31140416 hsa-mir-152 Colorectal Neoplasms CONCLUSIONS: miR-152 and miR-448 can down-regulate the protein expression of Rictor by targeting Rictor mRNA to negatively regulate the growth and colony formation of colorectal cancer cells. +transcription factor target 31140416 hsa-mir-448 Colorectal Neoplasms CONCLUSIONS: miR-152 and miR-448 can down-regulate the protein expression of Rictor by targeting Rictor mRNA to negatively regulate the growth and colony formation of colorectal cancer cells. +genetics_knock down_promote 31140328 hsa-mir-21 Sarcoma, Ewing Furthermore, using quantitative real-time PCR, RNA interference and luciferase reporter assay we demonstrated that activated leukocyte cell adhesion molecule (ALCAM/CD166) is a direct target of miR +circulation_biomarker_diagnosis_up 31140290 hsa-mir-126 Atrial Fibrillation Pri-miR-126 levels significantly decreased after ablation in the recurrent AF group, but the other miRNAs and pri-miRNAs did not. The measurement of s-TM and pri-miR-126 in blood was a useful tool to reflect the condition of AF patients with catheter ablation. +transcription factor target 31140131 hsa-mir-2911 Varicella Zoster Virus Infection These results indicated that, by targeting the IE62 gene, MIR2911 may effectively inhibit VZV replication. +circulation_biomarker_diagnosis_up 31140050 hsa-mir-9 Stomach Neoplasms 5p expression in GC cells and plasma was significantly decreased. +lncRNA target 31139863 hsa-mir-34a non-alcoholic steatohepatitis Our results indicate that activation of the miR-34a/SIRT1:AMPK pathway leads to mitochondrial dynamics dysfunction in skeletal muscle of human and experimental NAFLD, representing an appealing prospective target in metabolic syndrome. +lncRNA target 31138759 hsa-mir-198 Stomach Neoplasms Therapies targeted to miR-198 can potentially improve GC treatment. +genetics_knock down_promote 31138473 hsa-mir-664 Carcinoma, Squamous Cell, Cutaneous Knockdown of IRF2 reverses pro-tumorigenesis phenotype of miR-664; whereas IRF2 over-expression inhibits miR-664 tumorigenesis in cSCC. +other 31138431 hsa-mir-193b Fetal Growth Retardation 5p were significantly downregulated after adjustment for potential confounding factors in SGA infants with normal GWG compared to infants with NBWs and normal GWG. +other 31138431 hsa-mir-3679 Fetal Growth Retardation 5p were significantly downregulated after adjustment for potential confounding factors in SGA infants with normal GWG compared to infants with NBWs and normal GWG. +other 31138431 hsa-mir-335 Fetal Growth Retardation 5p were significantly downregulated after adjustment for potential confounding factors in SGA infants with normal GWG compared to infants with NBWs and normal GWG. +other 31138431 hsa-mir-3065 Fetal Growth Retardation 5p were significantly downregulated after adjustment for potential confounding factors in SGA infants with normal GWG compared to infants with NBWs and normal GWG. +other 31138431 hsa-mir-379 Fetal Growth Retardation 5p were significantly downregulated after adjustment for potential confounding factors in SGA infants with normal GWG compared to infants with NBWs and normal GWG. +lncRNA target 31138376 hsa-mir-298 Myocardial Ischemia miR-298 may serve as a promising targets for reducing myocardial ischemic injury. +genetics_overexpression_suppress 31138318 hsa-mir-499a Osteosarcoma Overexpression of miR-499a in CD166+ OSCs inhibits TGF-induced erlotinib-resistance in vitro and in vivo. +circulation_biomarker_diagnosis_up 31138255 hsa-mir-182 Squamous Cell Carcinoma of Head and Neck The levels of serum expression of miR-31, miR-141, miR-149a, miR-182, LET-7a, miR-4853p, miR-122 and miR-33 were up-regulated, and those of miR-145, miR-223 and miR-133a down-regulated, in the LSCC group compared to healthy controls. +circulation_biomarker_diagnosis_up 31138255 hsa-mir-122 Squamous Cell Carcinoma of Head and Neck The levels of serum expression of miR-31, miR-141, miR-149a, miR-182, LET-7a, miR-4853p, miR-122 and miR-33 were up-regulated, and those of miR-145, miR-223 and miR-133a down-regulated, in the LSCC group compared to healthy controls. +other 31138255 hsa-let-7a Squamous Cell Carcinoma of Head and Neck Particular miRNA signatures (miR-31, LET-7a and miR-33) may be considered as novel, non-invasive biomarkers for LC diagnosis. +circulation_biomarker_diagnosis_up 31138255 hsa-mir-149a Squamous Cell Carcinoma of Head and Neck The levels of serum expression of miR-31, miR-141, miR-149a, miR-182, LET-7a, miR-4853p, miR-122 and miR-33 were up-regulated, and those of miR-145, miR-223 and miR-133a down-regulated, in the LSCC group compared to healthy controls. +circulation_biomarker_diagnosis_up 31138255 hsa-mir-133a Squamous Cell Carcinoma of Head and Neck The levels of serum expression of miR-31, miR-141, miR-149a, miR-182, LET-7a, miR-4853p, miR-122 and miR-33 were up-regulated, and those of miR-145, miR-223 and miR-133a down-regulated, in the LSCC group compared to healthy controls. +other 31138255 hsa-mir-3 Squamous Cell Carcinoma of Head and Neck Particular miRNA signatures (miR-31, LET-7a and miR-33) may be considered as novel, non-invasive biomarkers for LC diagnosis. +circulation_biomarker_diagnosis_up 31138255 hsa-mir-145 Squamous Cell Carcinoma of Head and Neck The levels of serum expression of miR-31, miR-141, miR-149a, miR-182, LET-7a, miR-4853p, miR-122 and miR-33 were up-regulated, and those of miR-145, miR-223 and miR-133a down-regulated, in the LSCC group compared to healthy controls. +circulation_biomarker_diagnosis_up 31138255 hsa-mir-141 Squamous Cell Carcinoma of Head and Neck The levels of serum expression of miR-31, miR-141, miR-149a, miR-182, LET-7a, miR-4853p, miR-122 and miR-33 were up-regulated, and those of miR-145, miR-223 and miR-133a down-regulated, in the LSCC group compared to healthy controls. +other 31138255 hsa-mir-1 Squamous Cell Carcinoma of Head and Neck Particular miRNA signatures (miR-31, LET-7a and miR-33) may be considered as novel, non-invasive biomarkers for LC diagnosis. +circulation_biomarker_diagnosis_up 31138255 hsa-mir-485 Squamous Cell Carcinoma of Head and Neck The levels of serum expression of miR-31, miR-141, miR-149a, miR-182, LET-7a, miR-4853p, miR-122 and miR-33 were up-regulated, and those of miR-145, miR-223 and miR-133a down-regulated, in the LSCC group compared to healthy controls. +circulation_biomarker_diagnosis_up 31138255 hsa-mir-223 Squamous Cell Carcinoma of Head and Neck The levels of serum expression of miR-31, miR-141, miR-149a, miR-182, LET-7a, miR-4853p, miR-122 and miR-33 were up-regulated, and those of miR-145, miR-223 and miR-133a down-regulated, in the LSCC group compared to healthy controls. +lncRNA target 31138169 hsa-mir-188 Stomach Neoplasms 5p enhanced the migration and invasion of GC cells in vitro and tumor metastasis in vivo, whereas inhibition of miR +lncRNA target 31138033 hsa-mir-32 Glioma CONCLUSION: In summary, our finding suggests that miR-32 acts an important role in inhibiting glioma cell proliferation and metastasis and suppresses the expression of ABCC4 by directly targeting its 3'-untranslated region. +genetics_overexpression_promote 31137914 hsa-mir-551b Colorectal Neoplasms More importantly, miR551b overexpression was found to reduce the tumor size in a xenograft model of CRC cells in vivo. +genetics_knock down_promote 31137686 hsa-mir-155 Typical Teratoid Rhabdoid Tumor Knockdown of SMARCA4 mimicked the miR155-driven ATRT cell migration, whereas SMARCA4 overexpression or the delivery of exosomes with miR155 knockdown suppressed the migration. +lncRNA target 31137129 hsa-mir-497 Pancreatic Carcinoma Down-regulation of LINC01410 expression inhibits the proliferation and migration of pancreatic cancer BxPC-3 cells, and its mechanism may be closely related to regulating the miR5p and IFITM3 gene expression. +transcription factor target 31136988 hsa-mir-21 Lung Neoplasms Together, these findings show that miR-21 is a potential target for the development of treatment for NSCLC forms of human lung cancer. +other 31136983 hsa-mir-22 Lipid Metabolism Disorders In conclusion, miR-22 regulates TSH-induced thyroid cell proliferation and lipid metabolism disorder by impacting IL6R. +genetics_overexpression_promote 31136973 hsa-mir-139 Osteosarcoma Overexpression of miR-139 significantly inhibited OS cell proliferation, migration, and invasion. +other 31136754 hsa-mir-326 Obesity According to the results, the frequency of Th17 cells and RORC2 expression was higher in individuals with obesity and associated with miR-326 expression. Our results suggested that miR-326 participates in the polarization towards Th17 promoting the inflammatory state in the obesity-induced adipose tissue. +other 31136284 hsa-mir-1268b Stroke 5p). +other 31136284 hsa-mir-6090 Stroke 5p). +other 31136284 hsa-mir-6803 Stroke 5p). +other 31136284 hsa-mir-1228 Stroke 5p). +other 31136284 hsa-mir-4433b Stroke 5p). +other 31136006 hsa-mir-146a IgA Vasculitis Furthermore, miR-146a-5p and miR-148b-3p, which are negative regulators of inflammatory gene expression, showed decreased expression and could contribute to the exaggerated inflammation. +other 31136006 hsa-mir-223 IgA Vasculitis The expression of miR3p also showed a significant positive association with granulocyte infiltration and fibrinoid necrosis. +other 31136006 hsa-mir-148b IgA Vasculitis Furthermore, miR-146a-5p and miR-148b-3p, which are negative regulators of inflammatory gene expression, showed decreased expression and could contribute to the exaggerated inflammation. +epigenetics 31135262 hsa-mir-424 Ovarian Neoplasms Together, our research certifies that miR-424/503 cluster is silenced by DNA hypermethylation, which promotes the expression of KIF23, thereby regulating the proliferation and migration of ovarian cancer cells. +epigenetics 31135262 hsa-mir-503 Ovarian Neoplasms Together, our research certifies that miR-424/503 cluster is silenced by DNA hypermethylation, which promotes the expression of KIF23, thereby regulating the proliferation and migration of ovarian cancer cells. +genetics_overexpression_promote 31135177 hsa-mir-15a Prostatic Neoplasms The in vitro results showed that miR-15a-3p overexpression suppressed cell proliferation, invasion, and epithelial-mesenchymal transition (EMT) via down-regulating Wnt/beta-catenin signaling in PCa cells. +lncRNA target 31135068 hsa-mir-508 Stomach Neoplasms For the first time, we identified that HMGA1P4, a target of miR-301b/miR-508, is involved in cell cycle and senescence process by regulating CCNA2 in GC. +other 31134916 hsa-mir-34b Azoospermia, Nonobstructive In particular, we identified a combination of two miRNAs (miR-10b-3p and miR-34b-5p) that could serve as a predictive biomarker of azoospermia. +other 31134916 hsa-mir-10b Azoospermia, Nonobstructive In particular, we identified a combination of two miRNAs (miR-10b-3p and miR-34b-5p) that could serve as a predictive biomarker of azoospermia. +other 31134677 hsa-mir-224 Reperfusion Injury, Cerebral Ischemia CONCLUSIONS: We evaluated the function and mechanism of miR3p in ischemic brain injury. +genetics_knock down_promote 31134620 hsa-mir-27a Osteoarthritis, Knee Our study suggests that upregulation of miR-27a inhibits synovial angiogenesis and chondrocyte apoptosis in KOA rats through the inhibition of PLK2. +transcription factor target 31134615 hsa-mir-137 Melanoma These findings indicate that propofol suppressed melanoma cell proliferation, invasion, and migration by regulating miR-137 and FGF9. +other 31134483 hsa-mir-22 Classical Swine Fever The first report of genome-wide identification of differentially expressed miRNA in response to live attenuated vaccine virus of classical swine fever revealed miR5p and miR-27b-5p were differentially expressed at 7 dpv and 21 dpv. +other 31134483 hsa-mir-27b Classical Swine Fever The first report of genome-wide identification of differentially expressed miRNA in response to live attenuated vaccine virus of classical swine fever revealed miR5p and miR-27b-5p were differentially expressed at 7 dpv and 21 dpv. +genetics_overexpression_promote 31134446 hsa-mir-607 Colorectal Neoplasms Functional studies indicated that the overexpression of miR-3607 decreased CRC cell proliferation, migration and invasion. +lncRNA target 31134151 hsa-mir-181a Esophageal Squamous Cell Carcinoma We also found that miR-181a expression levels were increased in ESCC cell lines. Conclusions: CASC2 promoted the antitumor activity of cisplatin through inhibiting Akt pathway via negatively regulating miR-181a in ESCC cells. +transcription factor target 31133852 hsa-mir-218 Lipodystrophy A case control study showed that in subcutaneous adipose tissue from HIV-infected patients on cART presenting lipodystrophy (LS), the levels of miRNA-218 were upregulated and those of lipin-1, a putative target gene of miRNA-218, were downregulated compared with HIV-negative subjects. +transcription factor target 31133852 hsa-mir-218 Leigh Disease A case control study showed that in subcutaneous adipose tissue from HIV-infected patients on cART presenting lipodystrophy (LS), the levels of miRNA-218 were upregulated and those of lipin-1, a putative target gene of miRNA-218, were downregulated compared with HIV-negative subjects. +other 31133852 hsa-mir-218 Insulin Resistance Moreover, increased miRNA-218 levels were inversely correlated with changes in GLUT-4 expression, which suggests a role for miRNA-218 in mediating the insulin resistance consequent to cART. +transcription factor target 31133852 hsa-mir-218 Acquired Immunodeficiency Syndrome A case control study showed that in subcutaneous adipose tissue from HIV-infected patients on cART presenting lipodystrophy (LS), the levels of miRNA-218 were upregulated and those of lipin-1, a putative target gene of miRNA-218, were downregulated compared with HIV-negative subjects. +lncRNA target 31133357 hsa-mir-200a Lung Neoplasms This MALAT1/miR-200a axis could serve as new therapeutic target for lung cancer treatment. +other 31133163 hsa-mir-145 Endometriosis In conclusion, the up-regulated expression of miR-126 and miR-145 in the endometrial tissues in the mid-luteal phase of patients may play a role in infertility due to endometriosis. +other 31133163 hsa-mir-145 Infertility In conclusion, the up-regulated expression of miR-126 and miR-145 in the endometrial tissues in the mid-luteal phase of patients may play a role in infertility due to endometriosis. +other 31133163 hsa-mir-126 Endometriosis In conclusion, the up-regulated expression of miR-126 and miR-145 in the endometrial tissues in the mid-luteal phase of patients may play a role in infertility due to endometriosis. +other 31133163 hsa-mir-126 Infertility In conclusion, the up-regulated expression of miR-126 and miR-145 in the endometrial tissues in the mid-luteal phase of patients may play a role in infertility due to endometriosis. +lncRNA target 31132669 hsa-mir-194 Glioma In the mechanism, we found that LINC00909 could act as a ceRNA to interact with miR-194 and thereby up-regulate the expression of MUC1-C, thus promoting the proliferation and invasion of glioma cells. Collectively, these data demonstrated that LINC00909/miR-194/MUC1-C axis regulated glioma progression and might act as a novel therapeutic target. +lncRNA target 31132353 hsa-mir-34a Breast Neoplasms In vivo and in vitro experiments both showed that SNHG7 targeted miR-34a and promoted epithelial-to-mesenchymal transition (EMT) initiation and the Notch-1 pathway in breast cancer. In conclusion, SNHG7 promoted breast cancer tumorigenesis and progression by sponging miR-34a through EMT initiation and the Notch-1 pathway. +lncRNA target 31131895 hsa-mir-124 Neurologic Manifestations In this study, neonatal rats and hippocampal neurons were subjected to isoflurane exposure, in which the effect of miR-124 on the neurological deficits induced by isoflurane was evaluated. Upregulated miR-124 inhibited the expression of EGR1, by which mechanism miR-124 reduced the neurological deficits induced by isoflurane in neonatal rats through inhibiting apoptosis of hippocampal neurons. +other 31131637 hsa-mir-182 Lung Neoplasms Mechanistically, linc00858 acted as a competitive endogenous RNA to sponged miR-3182 and regulate MMP2 in lung cancer. +lncRNA target 31131537 hsa-mir-1270 Urinary Bladder Neoplasms Our study verified that Cdr1as exerts a cisplatin-chemosensitization effect on bladder cancer cells through the Cdr1as/miR-1270/APAF1 axis. +genetics_GWAS 31131489 hsa-mir-196a-2 Mucocutaneous Lymph Node Syndrome RESULTS: No significant associations were observed between the miRNA-196a2 rs11614913 T>C polymorphisms and Kawasaki disease risk (TC vs TT: adjusted OR = 1.04, 95% CI = 0.79-1.37; CC vs TT: adjusted OR = 0.87, 95% CI = 0.63-1.21; dominant model: adjusted OR = 0.99, 95% CI = 0.76-1.27; and recessive model: adjusted OR = 0.85, 95% CI = 0.64-1.13). +genetics_overexpression_promote 31131477 hsa-mir-182 Diabetic Nephropathies 5p and CD2AP in podocytes cells and suggested that the overexpression of miR +genetics_GWAS 31131469 hsa-mir-6515 Lung Neoplasms These results indicate that H19 may be an epigenetic regulator of miR +lncRNA target 31131448 hsa-mir-425 Laryngeal Neoplasms Long noncoding RNA LINC-PINT regulates laryngeal carcinoma cell stemness and chemoresistance through miR5p/PTCH1/SHH axis. +circRNA target 31131447 hsa-mir-1205 Glioma In conclusion, circMAN2B2 could improve cell proliferation, invasion, and migration of the glioma by inhibiting miR-1205 and promoting the expression of S100A8. +lncRNA target 31131445 hsa-mir-136 Neuralgia For another, miR-136 was obviously reduced in CCI rats. Overall, it was implied that CRNDE promoted neuropathic pain progression via modulating miR-136/IL6R axis in CCI rat models. +lncRNA target 31131409 hsa-mir-29a Sjogren's Syndrome As miR-29a and miR-29c are pro-apoptotic factors and several of the novel targets identified here are regulators of apoptosis, their downregulation in patients with pSS is associated with enhanced pDC survival. +lncRNA target 31131409 hsa-mir-29c Sjogren's Syndrome As miR-29a and miR-29c are pro-apoptotic factors and several of the novel targets identified here are regulators of apoptosis, their downregulation in patients with pSS is associated with enhanced pDC survival. +transcription factor target 31131392 hsa-mir-28 Atrial Fibrillation CACNA1c and CACNA2b expression decreased and miR-328 increased in RA and LA during AF. Age-related miR-328 dysregulation and reduced ICa,L may contribute to increased AF susceptibility with age. +other 31131047 hsa-mir-203 Adenocarcinoma of Lung Finally, we demonstrated that upregulation of HCP5 increases the expression of Snail and Slug by sponging the microRNA-203 (miR-203) and promoting epithelial-mesenchymal transition (EMT) in LUAD cells. +lncRNA target 31131011 hsa-mir-107 Colorectal Neoplasms CONCLUSION: MiR-107 suppresses the metastasis of colorectal cancer and could be a potential therapy target in colorectal cancer patients. +genetics_knock down_promote 31130744 hsa-mir-206 Arthritis, Rheumatoid Conclusions Taken together, our results indicate the importance of miR-206 expression in patients with RA, as a potential new biomarker that affects bone loss/deformity and its collaborative role with proinflammatory cytokines such as IL-16 and IL-17 in RA bone metabolism. +circulation_biomarker_prognosis_up 31130720 hsa-mir-23a ST Elevation Myocardial Infarction The evaluation of miR-23a-3p expression levels in serum could be useful to assess the severity of STEMI and as a potential diagnostic biomarker of this condition. +other 31130520 hsa-mir-210 Breast Neoplasms Importantly, it cleaved pre-miR-210 substoichiometrically and induced apoptosis in breast cancer cells. +lncRNA target 31130475 hsa-mir-200b Carcinoma, Renal Cell INTERPRETATION: These results demonstrate a previously undescribed role of miR-200b as a suppressor of tumor metastasis in RCC by directly destabilizing LAMA4 mRNA. +transcription factor target 31130368 hsa-mir-34a Autoimmune Diseases Taken together, we show that NF-B activated by inflammatory cytokines, such as IL-6 and TNF-, ameliorates Foxp3 levels via regulating miR-34a expression, which provides a new mechanistic and therapeutic insight into the ongoing of autoimmune diseases. +circulation_biomarker_diagnosis_up 31130368 hsa-mir-34a Arthritis, Rheumatoid The human miR-34a, increased in peripheral blood mononuclear cells (PBMCs) and CD4+ T cells from rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) patients, displayed a positive correlation with some serum markers of inflammation including rheumatoid factor (RF), anti-streptolysin antibody (ASO), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) as well as Th17 signature gene RORt, but inversely correlated with the mRNA expression levels of FOXP3. +circulation_biomarker_diagnosis_up 31130368 hsa-mir-34a Lupus Erythematosus, Systemic The human miR-34a, increased in peripheral blood mononuclear cells (PBMCs) and CD4+ T cells from rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) patients, displayed a positive correlation with some serum markers of inflammation including rheumatoid factor (RF), anti-streptolysin antibody (ASO), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) as well as Th17 signature gene RORt, but inversely correlated with the mRNA expression levels of FOXP3. +transcription factor target 31130358 hsa-mir-135a Brain Diseases Prospectively, the miRIP3 axis might represent a novel target of therapeutic intervention to prevent pathological brain aging. +lncRNA target 31129966 hsa-mir-107 Prostatic Neoplasms MiR-107 was found to target cyclin E1 (CCNE1) in PCa cells by directly binding to its 3'-UTR. +circulation_biomarker_diagnosis_up 31129965 hsa-mir-1 Nasopharyngeal Carcinoma Thus, we concluded that circulating miR +genetics_GWAS 31129811 hsa-mir-494 Osteoblastoma Experiments showed that the overexpression of miR-494 correlated with a marked reduction in osteoblast differentiation genes and a decrease in osteogenesis in BMP2-induced osteogenetic differentiation. +epigenetics 31129659 hsa-mir-34b Vascular Calcification Bisulphite sequencing PCR (BSP) uncovered that CpG sites upstream of miR-34b DNA were hypermethylated in calcified VSMCs and calcified arteries due to 5/6 NTP, as well as calcified renal arterial tissues from uraemia patients. +other 31129437 hsa-mir-140 Depression, Postpartum 5p might be involved in the pathogenesis of late-onset PSD and used as a novel early warning biomarker. +genetics_overexpression_promote 31129247 hsa-mir-21 Carcinoma, Non-Small-Cell Lung TP73-AS1 and miR-21 overexpression caused the accelerated invasion and migration of NSCLC cells. Therefore, TP73-AS1 may upregulate miR-21 to promote NSCLC cell migration and invasion. +genetics_GWAS 31129246 hsa-mir-10b Melanoma Taken together, our results demonstrated that miR-10b was an important epigenetic modifier, promoting melanoma progression through regulating ITCH/Wnt/beta-catenin pathway. +exosome 31129098 hsa-mir-1246 Breast Neoplasms Furthermore, BCF treatment downregulated exosomal miR-1246 level, which in turn decreased angiogenesis in brain environment. +lncRNA target 31128917 hsa-mir-150 Melanoma 5p) inhibits SIX1 expression by directly targeting its 3'-UTR in melanoma cells. +tissue_expression_ns 31128573 hsa-mir-138 Adenocarcinoma of Lung Next, we evaluated the effects of HMMR-AS1 on LUAD cell proliferation and apoptosis, and its regulation of miR-138 by acting as a ceRNA. +transcription factor target 31128295 hsa-mir-155 Ataxia Telangiectasia Additionally, over- and suppressed expression of miR5p significantly enhanced and reduced the IL-2 and IL-1beta expressions in RTG-2cells induced by A. +other 31128240 hsa-mir-181a Brain Ischemia Pronounced differences between CA1 and DG were observed for several select miRNAs, including miR-181a-5p, a known regulator of cerebral ischemic injury. +other 31128151 hsa-mir-29a Diabetes Mellitus, Type 2 YPHL decoction attenuated IR in T2DM probably by down-regulating or maintaining the miR-29a-3p level, increasing the expression of IRS1 mRNA and its phosphorylated proteins, and regulating the expression of insulin receptor signaling-related proteins. +other 31128089 hsa-let-7g Pre-Eclampsia Our data indicated that let-7a and let-7g may be considered as predictive markers for SPE. +other 31128089 hsa-let-7a Pre-Eclampsia Our data indicated that let-7a and let-7g may be considered as predictive markers for SPE. +genetics_knock down_promote 31128041 hsa-mir-29c Melanoma The mimic and inhibitor of microRNA-29c were transfected into melanoma cells to achieve microRNA-29c overexpression or knockdown so as to observe the biological effect on the melanoma cells. +lncRNA target 31128039 hsa-mir-124 Esophageal Squamous Cell Carcinoma Rescue experiments were performed to assess whether miR-124 could regulate the proliferation, migration and apoptosis of esophageal cancer cells by inhibiting PDCD6 expression. +genetics_overexpression_promote 31128038 hsa-mir-19a Urinary Bladder Neoplasms RESULTS: miR-19a was clearly overexpressed in bladder cancer tissues and cells, while the expression of RhoB was lower in bladder cancer tissues and cells as compared with corresponding paracancer tissues and normal bladder cells. +circulation_biomarker_prognosis_ns 31128037 hsa-mir-143 Urinary Bladder Neoplasms CONCLUSION: mir-143 is lowly expressed in the serum of bladder cancer patients. +lncRNA target 31128030 hsa-mir-497 Pancreatic Carcinoma CONCLUSIONS: LINC00339 was markedly over-expressed in PANC tissues and cells and promoted cell proliferation, invasion, and migration via sponging miR5p, thereby increasing IGF1R expression. +lncRNA target 31128026 hsa-mir-93 Ovarian Neoplasms CONCLUSION: The findings of this study suggested L-THP increased the sensitivity of ovarian cancer cells to cisplatin via modulating miR-93/PTEN/AKT pathway in A2780/DDP ovarian cancer cell line. +circulation_biomarker_diagnosis_ns 31128012 hsa-mir-660 Carcinoma, Non-Small-Cell Lung 5p in plasma and exosomes was increased in patients with NSCLC (n=80). +genetics_knock down_promote 31128011 hsa-mir-203 Carcinoma, Non-Small-Cell Lung MicroRNA-203 knockdown inhibited proliferative, migratory and invasive abilities of NSCLC cells. +genetics_overexpression_promote 31127997 hsa-mir-485 Breast Neoplasms CONCLUSIONS Overexpression of circ-10021 promotes the proliferative and migratory capacities of breast cancer cells by sponging microRNA +other 31127907 hsa-mir-26a Prostatic Neoplasms The primary aim of this study was to assess whether circulatory miR-20a and miR-26a can be used as diagnostic biomarkers in prostate cancer (PCa). Methods: Relative expression miR-20a and miR-26a has been assessed in 40 patients with PCa and 40 non-cancerous volunteer. +other 31127907 hsa-mir-20a Prostatic Neoplasms The primary aim of this study was to assess whether circulatory miR-20a and miR-26a can be used as diagnostic biomarkers in prostate cancer (PCa). +circulation_biomarker_diagnosis_down 31127902 hsa-mir-210 Stomach Neoplasms In the present study, the expression profile of four microRNAs, miR-103, miR-107, miR-194 and miR-210 were evaluated in patients with intestinal-type of gastric cancer (IGC) in order to assess their diagnosis utility as noninvasive biomarkers. Conclusion: These findings suggest that the plasma levels of miR-107, miR-194 and miR-210 were downregulated in patients with ICG and propose these molecules as potential non-invasive biomarkers for detection of IGC. +circulation_biomarker_diagnosis_down 31127902 hsa-mir-107 Stomach Neoplasms In the present study, the expression profile of four microRNAs, miR-103, miR-107, miR-194 and miR-210 were evaluated in patients with intestinal-type of gastric cancer (IGC) in order to assess their diagnosis utility as noninvasive biomarkers. Conclusion: These findings suggest that the plasma levels of miR-107, miR-194 and miR-210 were downregulated in patients with ICG and propose these molecules as potential non-invasive biomarkers for detection of IGC. +circulation_biomarker_diagnosis_down 31127902 hsa-mir-194 Stomach Neoplasms In the present study, the expression profile of four microRNAs, miR-103, miR-107, miR-194 and miR-210 were evaluated in patients with intestinal-type of gastric cancer (IGC) in order to assess their diagnosis utility as noninvasive biomarkers. Conclusion: These findings suggest that the plasma levels of miR-107, miR-194 and miR-210 were downregulated in patients with ICG and propose these molecules as potential non-invasive biomarkers for detection of IGC. +other 31127902 hsa-mir-103 Stomach Neoplasms In the present study, the expression profile of four microRNAs, miR-103, miR-107, miR-194 and miR-210 were evaluated in patients with intestinal-type of gastric cancer (IGC) in order to assess their diagnosis utility as noninvasive biomarkers. +lncRNA target 31127852 hsa-mir-105 Liver Neoplasms In summary, CD44 regulates PES1 in liver cancer stem cells via miR5p to promote cell growth. +other 31127661 hsa-mir-210 Squamous Cell Carcinoma of Head and Neck This network predicted that two lncRNAs (AC016773.1 and C00299), two mRNAs (DIO1 and STC2), and two miRNAs (hsa-mir-137 and hsa-mir-210) were significant biomarkers of LSCC prognosis according to thorough topological and survival analyses (P < .05). +exosome 31127654 hsa-mir-296 Carcinoma, Hepatocellular HANR promotes lymphangiogenesis of hepatocellular carcinoma via secreting miR-296 exosome and regulating EAG1/VEGFA signaling in HDLEC cells. +lncRNA target 31127646 hsa-mir-92b Prostatic Neoplasms This finding suggests that the dysregulation between hsa-let-7a-5p/CDKN1A and hsa-miR-92b-3p/GSTM3 pairs is associated with platinum-based chemoresistance of metastatic cancer cells. +lncRNA target 31127646 hsa-let-7a Prostatic Neoplasms This finding suggests that the dysregulation between hsa-let-7a-5p/CDKN1A and hsa-miR-92b-3p/GSTM3 pairs is associated with platinum-based chemoresistance of metastatic cancer cells. +genetics_overexpression_suppress 31127537 hsa-mir-374a Osteochondritis Dissecans We found that overexpression of miR-374a-5p reduced cell apoptosis through inhibiting PTEN/PI3K pathway in PC12 cells treated by OGD. +other 31127537 hsa-mir-374a hyper IgE recurrent infection syndrome 2 miR-374a-5p was downregulated in cells derived from human newborns with HIE, rat model with HIE, and PC12 cells after the OGD treatment. +other 31127537 hsa-mir-374a Hypoxia-Ischemia, Brain Previous studies found that miR-374a-5p was decreased in infants suffering from the hypoxic-ischemic encephalopathy (HIE) compared with healthy control infants. +genetics_GWAS 31127299 hsa-mir-196a-2 Lung Neoplasms In conclusion, miR-146a and miR-196a-2 genes polymorphisms and their circulating levels were associated with lung cancer risk in Egyptians and may be helpful in early detection of lung cancer. +genetics_knock down_promote 31127025 hsa-mir-197 Breast Neoplasms 3p inhibitor reversed the promoting effects of LIFR-AS1 knockdown on breast cancer cell proliferation, colony formation, migration and invasion. +other 31126802 hsa-mir-222 Cardiovascular Diseases Despite the association with tumors and cardiovascular diseases, the role of miR-222 in NAFLD remains unclear. +genetics_knock down_suppress 31126198 hsa-mir-193b nonpapillary renal cell carcinoma Overexpression miR-193b or knockdown of IGF1R significantly inhibited the abilities of cells proliferation, migration and invasion in renal cell carcinoma. +other 31126193 hsa-mir-143 Osteosarcoma Objective: To investigate the effects of miR3p and MAPK7 on the proliferation, migration, and invasion of U2OS human osteosarcoma (OS) cells. +tissue_expression_ns 31125664 hsa-mir-146a Vitamin B Deficiency At same time, miRNA-146a, which should have increased to regulate the inflammatory response, was reduced with Se deficiency. +genetics_knock down_promote 31125260 hsa-mir-214 Colorectal Neoplasms Knockdown of long noncoding RNA PVT1 suppresses cell proliferation and invasion of colorectal cancer via upregulation of microRNA +genetics_overexpression_promote 31125123 hsa-mir-133a Colorectal Neoplasms VPS33B overexpression suppressed CRC proliferation, intrahepatic metastasis and chemoresistance of cisplatin (DDP) in vivo and in vitro through modulating the epidermal growth factor receptor (EGFR)/RAS/ERK/c-Myc/p53/miR-133a-3p feedback loop and the downstream cell cycle or EMT-related factors. Taken together, VPS33B as a tumor suppressor is easily dysregulated by chemical carcinogens and it interacts with NESG1 to modulate the EGFR/RAS/ERK/c-Myc/p53/miR-133a-3p feedback loop and thus suppress the malignant phenotype of CRC. +other 31125087 hsa-mir-576 Cardiovascular Diseases miR5p may contribute to the regulation of postnatal growth and influence the risk for cardiometabolic diseases associated with a mismatch between prenatal and postnatal weight gain. +genetics_GWAS 31124563 hsa-mir-27a Head and Neck Neoplasms Genetic alterations in TP53, a frequent event in HNSCC, disrupt this regulatory loop by repressing miR-27a* expression, promoting tumor survival. +other 31124410 hsa-mir-21 Breast Neoplasms The miR223-3p, miR-421 and miR5p were validated in an independent cohort of 431 breast cancer patients from The Cancer Genome Atlas (TCGA). +other 31124410 hsa-mir-223 Breast Neoplasms The miR223-3p, miR-421 and miR5p were validated in an independent cohort of 431 breast cancer patients from The Cancer Genome Atlas (TCGA). +other 31124410 hsa-mir-421 Breast Neoplasms The miR223-3p, miR-421 and miR5p were validated in an independent cohort of 431 breast cancer patients from The Cancer Genome Atlas (TCGA). +genetics_knock down_promote 31124340 hsa-mir-140 Fibrosis 3p knockdown suppresses cell proliferation and fibrogenesis in TGF +transcription factor target 31124332 hsa-mir-218 Adenocarcinoma of Lung 5p suppresses the killing effect of NK cells to LA cells by targeting SHMT1, providing a potential target for LA treatment by ameliorating NK cells function. +lncRNA target 31124216 hsa-mir-199 Rhinitis, Allergic A dual-reporter assay was used to confirm the direct targeting of miR +other 31124075 hsa-mir-233 Arthritis, Rheumatoid Moreover, miR3p was downregulated after RTX injection and upregulated by EA treatment. +other 31123908 hsa-mir-378a Colonic Neoplasms In patients with early stage II colon cancer, miR-378 can be used as a biomarker of colorectal cancer. +other 31123908 hsa-mir-378 Colonic Neoplasms In patients with early stage II colon cancer, miR-378 can be used as a biomarker of colorectal cancer. +circRNA target 31123738 hsa-mir-21 Lung Neoplasms Herein, we develop an isothermal miRNA detection platform based on the highly efficient, multiple primer-mediated rolling circle amplification method coupled with a graphene oxide-based fluorescence (MPRCA-GO) assay, using lung cancer-associated miRNAs (miR-21 and miR-210) and a reference miRNA (miR-16) as model targets. +circRNA target 31123738 hsa-mir-210 Lung Neoplasms Herein, we develop an isothermal miRNA detection platform based on the highly efficient, multiple primer-mediated rolling circle amplification method coupled with a graphene oxide-based fluorescence (MPRCA-GO) assay, using lung cancer-associated miRNAs (miR-21 and miR-210) and a reference miRNA (miR-16) as model targets. +lncRNA target 31123414 hsa-mir-26a Myocarditis Conclusion: We demonstrate that MALAT1 is induced by SFAs and its downregulation alleviates SFA-induced myocardial inflammatory injury via the miR-26a/HMGB1/TLR4/NF-kappaB axis. +lncRNA target 31123409 hsa-mir-506 Retinoblastoma AS might be a potential therapeutic target for RB. +circRNA target 31123169 hsa-mir-194 Laryngeal Neoplasms 5p attenuated the inhibitory effects of hsa_circ_0023028 silencing on LCa cell proliferation, migration, and invasion. +lncRNA target 31122822 hsa-mir-148a Pancreatitis In addition, IL-6 and AG490, the IL-6/STAT3 signaling inhibitor, were used to verify the role of IL-6/STAT3 signaling in the regulation of miR-148a on autophagy in cerulein-induced AP in vitro and in vivo. +other 31122764 hsa-mir-515 Breast Neoplasms Perturbation of pri-miR-515 results in the upregulation of HER2 protein levels, rendering HER2- breast cancer cells more sensitive to Herceptin treatment. +other 31122764 hsa-mir-515 Glycogen Storage Disease Type VI Perturbation of pri-miR-515 results in the upregulation of HER2 protein levels, rendering HER2- breast cancer cells more sensitive to Herceptin treatment. +lncRNA target 31122697 hsa-mir-613 Stomach Neoplasms In conclusion, miR-613 served as a tumor suppressor by targeting PFKFB2, indicating that detecting miR-613 and modulation of miR-613 expression could be potential marker and clinical approach in GC patients. +other 31122533 hsa-mir-146b Endometriosis CONCLUSIONS Our findings suggest an important role of miR-146b level and variants in endometriosis that helps to regulate the process of endometriosis and its associated pain. +other 31122533 hsa-mir-146b Endometritis CONCLUSIONS Our findings suggest an important role of miR-146b level and variants in endometriosis that helps to regulate the process of endometriosis and its associated pain. +transcription factor target 31122291 hsa-mir-497 isolated cleft palate 3p suppresses cell proliferation through the regulation of human CL/P-candidate genes. +transcription factor target 31122291 hsa-mir-655 isolated cleft palate 3p suppresses cell proliferation through the regulation of human CL/P-candidate genes. +other 31122084 hsa-mir-601 Hypersensitivity Significant differences were found between the patients with wasp venom allergy and the healthy controls in the expression of miR-601 and miR-1201 upregulated in allergic patients at every time point (p = 0.04; p = 0.015, respectively). +other 31122084 hsa-mir-601 Rhinitis, Allergic, Seasonal Significant differences were found between the patients with wasp venom allergy and the healthy controls in the expression of miR-601 and miR-1201 upregulated in allergic patients at every time point (p = 0.04; p = 0.015, respectively). +other 31122084 hsa-mir-1201 Rhinitis, Allergic, Seasonal Significant differences were found between the patients with wasp venom allergy and the healthy controls in the expression of miR-601 and miR-1201 upregulated in allergic patients at every time point (p = 0.04; p = 0.015, respectively). +other 31122084 hsa-mir-1201 Hypersensitivity Significant differences were found between the patients with wasp venom allergy and the healthy controls in the expression of miR-601 and miR-1201 upregulated in allergic patients at every time point (p = 0.04; p = 0.015, respectively). +lncRNA target 31121595 hsa-mir-147b Colorectal Neoplasms CONCLUSIONS: miR-147b not only plays important roles in the regulation of cell proliferation and tumor growth in CRC, which might be a potential prognostic marker or therapeutic target for CRC. +lncRNA target 31121484 hsa-mir-206 Carcinoma, Non-Small-Cell Lung 3p/ABCB1 pathway, contributing to a better understanding of SNHG14 in acquired resistance and elucidating a candidate target to improve treatment response of NSCLC patients. +other 31121483 hsa-mir-498 Glioma Taken together, the data suggest the regulation of SP1/CASC11/miR-498/FOXK1 in the gliomagenesis, which might provide a potential therapeutic strategy for glioma. +genetics_overexpression_promote 31121479 hsa-mir-150 Carcinoma, Non-Small-Cell Lung 5p functions as a CSC suppressor and that overexpression of miR +lncRNA target 31120927 hsa-mir-873 Breast Neoplasms Here we report that Norcantharidin (NCTD), currently used clinically as an ani-cancer drug in China, regulates miR-873/CDK3 axis in breast cancer cells. Our data shows that NCTD regulates ERalpha signaling and tamoxifen resistance by targeting miR-873/CDK3 axis in breast cancer cells. +lncRNA target 31120592 hsa-mir-92b Spinal Cord Injuries Collectively, these results indicate that miR-92b-3p promotes neurite growth and functional recovery through the PTEN/AKT pathway in ASCI. +transcription factor target 31120140 hsa-mir-139 Colonic Neoplasms 5p and its target E2-2. +lncRNA target 31119955 hsa-mir-34b Uterine Cervical Neoplasms Conclusions: MiR-34b and TGF-beta1 contribute to cervical cancer cell proliferation and apoptosis and are potential targets for cervical cancer therapeutics. +transcription factor target 31119862 hsa-mir-193a Leukemia, Myeloid, Acute Mechanistically, MLT increased the expression of miR-193a, which inhibited AML1-ETO expression via targeting its putative binding sites. Thus, MLT presents anti-self-renewal of LSC through miR-193a-AML1-ETO-beta-catenin axis. +other 31119810 hsa-mir-145 Esophageal Squamous Cell Carcinoma Therefore, lncRNA Erbb4-IR may promote ESCC by downregulating miR-145. +other 31119810 hsa-mir-145 Esophageal Neoplasms Therefore, lncRNA Erbb4-IR may promote ESCC by downregulating miR-145. +other 31119790 hsa-mir-103 Lung Neoplasms Our experiments demonstrate that the TRHDE-AS1/miR-103/KLF4 axis may provide new evidence for understanding the molecular basis of lung cancer. +lncRNA target 31119784 hsa-mir-216a Breast Neoplasms Our results collectively suggest that miR-216a suppressed migration and promoted apoptosis in breast cancer cells by targeting PKCalpha. +lncRNA target 31119777 hsa-mir-196a Alzheimer Disease In addition, restored miR-196a and deleted LRIG3 ameliorated spatial learning and memory capability, suppressed the pathological injury, induced the survival, and suppressed the apoptosis of hippocampal neurons, as well as inhibited oxidative stress injury together with inflammatory injury in AD rats. +genetics_GWAS 31119161 hsa-mir-191 Pulmonary Arterial Hypertension Finally, we found that miR-191 repressed the expression of bone morphogenetic protein receptor 2 (BMPR2) in HPAECs and PAH rats. Thus, we conjectured that miR-191, in ASCs and ASCs-Exos, plays an important role in PAH via regulation of BMPR2. +lncRNA target 31118816 hsa-mir-497 Pancreatic Carcinoma CONCLUSION: Collectively, these findings suggested that DLX6-AS1/miR5p/FZD4/FZD6/Wnt/beta-catenin signaling pathway is involved in the pathogenesis of PC, and DLX6-AS1 could be a potential biomarker and target for PC treatment. +lncRNA target 31118802 hsa-mir-1231 Stomach Neoplasms Conclusion: Our results indicate that LINC00673 rs11655237 is associated with an increased GC risk, possibly by down-regulating LINC00673 expression through creating a miR-1231 binding site. +transcription factor target 31118777 hsa-mir-17 Colorectal Neoplasms Conclusions: Our study indicated that upregulated miR-17 may promote the progression of CRC and may exert its function as a tumor suppressor miRNA by targeting SIK1. +genetics_overexpression_promote 31118688 hsa-mir-338 Prostatic Neoplasms Conclusion: Overexpression of circHIPK3 promotes the proliferative and invasive potentials of PCa cells through sponging miRNA +genetics_knock down_promote 31118686 hsa-mir-26a Colorectal Neoplasms Conclusion: SNHG6 knockdown suppressed cell migration, invasion, and EMT at least partly by sponging miR-26a and regulating EZH2 expression in CRC cells, providing a strategy for blocking CRC metastasis. +genetics_overexpression_promote 31118676 hsa-mir-143 Colorectal Neoplasms 3p overexpression suppressed cell proliferation, migration and invasion in CRC. +genetics_knock down_promote 31118671 hsa-mir-155 Uterine Cervical Neoplasms Finally, overexpression of TP53INP1 impaired the promote effect of miR +genetics_knock down_promote 31118494 hsa-mir-4295 Squamous Cell Carcinoma of Head and Neck It was indicated by further investigation that the effect of miR-4295 suppression on cell proliferation, migration and EMT process in HNSCC can be restored by knockdown of NPTX1 at the same time. +circulation_biomarker_diagnosis_ns 31118200 hsa-mir-195 Breast Neoplasms 5p, and miR-203a-3p in circulating EV and decreased ONECUT2 expression and increased levels of stemness-associated genes. +circulation_biomarker_diagnosis_ns 31118200 hsa-mir-9 Breast Neoplasms 5p, and miR-203a-3p in circulating EV and decreased ONECUT2 expression and increased levels of stemness-associated genes. +circulation_biomarker_diagnosis_ns 31118200 hsa-mir-203a Breast Neoplasms 5p, and miR-203a-3p in circulating EV and decreased ONECUT2 expression and increased levels of stemness-associated genes. +genetics_overexpression_promote 31118065 hsa-let-7b Melanoma Overexpression of miR-let-7b or miR-let-7c in patient-derived xenograft (PDX) models and certain mucosal melanoma cells had better growth inhibition after temozolomide and paclitaxel treatment. +genetics_overexpression_promote 31118065 hsa-let-7c Melanoma Overexpression of miR-let-7b or miR-let-7c in patient-derived xenograft (PDX) models and certain mucosal melanoma cells had better growth inhibition after temozolomide and paclitaxel treatment. +genetics_GWAS 31117970 hsa-mir-495 Colorectal Neoplasms CONCLUSION: In this study, we found that miR-200b and miR-495 polymorphisms are involved in CRC susceptibility and prognosis. +other 31117868 hsa-mir-486 Carcinoma, Non-Small-Cell Lung 5p levels compared with A549 cells. +other 31116113 hsa-mir-155 Panniculitis, Peritoneal We aimed to evaluate CD64, calprotectin, and microRNA-155 (miR-155) levels as diagnostic markers of spontaneous bacterial peritonitis (SBP) and the effect of using more than one use on the same spot over their diagnostic efficiency. CONCLUSION: CD64, calprotectin, and miR-155 were good diagnostic markers of SBP and on using this combination, greater efficiency in diagnosis was achieved. +other 31116090 hsa-mir-1200 Osteosarcoma In conclusion, circ-0001785 regulates the pathogenesis of osteosarcoma by sponging miR-1200 to up-regulate HOXB2 expression. +lncRNA target 31115975 hsa-mir-145 Ovarian Neoplasms Together, our results revealed that miR-145 inhibited glutamine metabolism through c-myc/GLS1 pathways in ovarian cancer cells, which may improve the current strategy of ovarian cancer diagnosis and therapy. +lncRNA target 31115969 hsa-mir-126 Melanoma In view of the important tumor suppressor function induced by restoring expression of microRNA (miR)-126 in metastatic melanoma cells, we examined whether miR-126 has a synergistic role when included in a triple combination alongside PIK-75 and vemurafenib. These results not only show the efficacy of PIK-75 and vemurafenib co-treatment but also indicate that restoration of miR-126 expression in advanced melanoma can enhance their antitumor activity, which may possibly allow dose reduction to decrease adverse events without reducing the therapeutic benefits. +other 31115881 hsa-mir-18a Breast Neoplasms Clinical, in vitro and in silico data support the role of miR-18a in breast cancer cell proliferation and endocrine resistance and suggest its potential utility as a biomarker for additional adjuvant treatment in patients without a pathologic complete response to neoadjuvant therapy. +transcription factor target 31115583 hsa-mir-767 Glioma Our results indicated that forced upregulation of miR7675p may represent a novel therapeutic strategy for glioma patients by targeting SUZ12. +lncRNA target 31115580 hsa-mir-21 Melanoma Together, the findings demonstrated miR21 inhibitor facilitated the anticancer activity of DLN in melanoma, and the mechanisms involved Bcl2, Bax and P53 expression. +other 31115569 hsa-mir-21 Ovarian Neoplasms miR21 regulated the expression of CD44v6 by activating the Wnt signaling pathway, which plays an important role in the development of ovarian cancer. +lncRNA target 31115562 hsa-mir-497 Carcinoma, Non-Small-Cell Lung Additionally, miR497 directly targeted and downregulated KDR expression, and inhibited malignant behaviors of NSCLC cells. +lncRNA target 31115561 hsa-mir-22 Ischemic Stroke These results suggested that miRNA22 can alleviate ischemic strokeinduced inflammation in rats model or vitro model through p38 MAPK/NFkappaB pathway suppression. +lncRNA target 31115560 hsa-mir-181 Multiple Myeloma The MM cell line RPMI 8226 stably transduced with miR181a mimics or inhibitor was established via lentiviral vectors. +lncRNA target 31115560 hsa-mir-181a Multiple Myeloma The MM cell line RPMI 8226 stably transduced with miR181a mimics or inhibitor was established via lentiviral vectors. +other 31115556 hsa-mir-21 Reperfusion Injury Therefore, the purpose of the present study was to demonstrate the involvement of miR21 in the cardioprotective mechanisms of puerarin using a cell model of I/R injury, generated by culturing rat H9c2 cardiomyocytes under H/R conditions. +circulation_biomarker_diagnosis_ns 31115543 hsa-mir-144 Osteoporosis-pseudoglioma syndrome The results showed that the levels of miR144, Sfrp1 and TNFalpha in clinical serum samples obtained from patients with postmenopausal OP were higher than those in serum samples obtained from postmenopausal women with normal bone density. +circulation_biomarker_diagnosis_ns 31115543 hsa-mir-144 Osteoporosis, Postmenopausal The results showed that the levels of miR144, Sfrp1 and TNFalpha in clinical serum samples obtained from patients with postmenopausal OP were higher than those in serum samples obtained from postmenopausal women with normal bone density. +genetics_knock down_promote 31115539 hsa-mir-889 Carcinoma, Non-Small-Cell Lung Moreover, a TAB1 knockdown had effects similar to that of miR889 overexpression, whereas restoration of TAB1 expression counteracted the actions of miR889 in NSCLC cells. +other 31115534 hsa-mir-10b Labyrinth Diseases These 3 miRNAs may be involved in AIED by affecting inflammatory chemokine (miR10b3pCC motif chemokine 12), Wnt signaling (miR8112Wnt9b/Wnt 3a/Wnt2b) and Mucin type Oglycan biosynthesis pathways (let7jGalnt2/Galnt12). In conclusion, miR10b3p, miR8112 and let7j may be underlying biomarkers for diagnosing AIED. +other 31115534 hsa-mir-8112 Labyrinth Diseases These 3 miRNAs may be involved in AIED by affecting inflammatory chemokine (miR10b3pCC motif chemokine 12), Wnt signaling (miR8112Wnt9b/Wnt 3a/Wnt2b) and Mucin type Oglycan biosynthesis pathways (let7jGalnt2/Galnt12). In conclusion, miR10b3p, miR8112 and let7j may be underlying biomarkers for diagnosing AIED. +other 31115534 hsa-let-7j Labyrinth Diseases These 3 miRNAs may be involved in AIED by affecting inflammatory chemokine (miR10b3pCC motif chemokine 12), Wnt signaling (miR8112Wnt9b/Wnt 3a/Wnt2b) and Mucin type Oglycan biosynthesis pathways (let7jGalnt2/Galnt12). In conclusion, miR10b3p, miR8112 and let7j may be underlying biomarkers for diagnosing AIED. +other 31115532 hsa-mir-135b Polycystic Ovary Syndrome At the validation phase, the levels of Homo sapiens (hsa)miR3188 and hsamiR3135b were significantly higher in the PCOS group than in the control group. +other 31115532 hsa-mir-188 Polycystic Ovary Syndrome At the validation phase, the levels of Homo sapiens (hsa)miR3188 and hsamiR3135b were significantly higher in the PCOS group than in the control group. +genetics_overexpression_promote 31115528 hsa-mir-34a Glioma Furthermore, downregulation of miR34a using antimiR34a induced MMP9 protein expression in glioma cells; whereas, overexpression of miR34a suppressed MMP9 protein expression in glioma cells. +transcription factor target 31115523 hsa-mir-342 Glioma Our findings demonstrated that miR342 regulates the cell proliferation of glioma by targeting GPRC5A, which indicates that miR342 is a target of interest regarding the treatment of refractory glioma, and it may provide a promising prognostic and therapeutic strategy for glioma treatment. +lncRNA target 31115512 hsa-mir-623 Pancreatic Carcinoma Consequently, hsamiR623 inhibited pancreatic cancer cell migration and invasion in vitro and metastasis in vivo. +circulation_biomarker_diagnosis_up 31115511 hsa-mir-122 Cholangiocarcinoma Consistently, the serum leptin level positively correlated with that of PKM2, but negatively with that of miR122 in patients with cholangiocarcinoma. +lncRNA target 31115507 hsa-mir-421 Carcinoma, Non-Small-Cell Lung In addition, miR421 inhibited NSCLC cell apoptosis by flow cytometry apoptosis assay, as evidenced by antiapoptosis gene Bcl2 and apoptosis gene cleaved caspase3 and cleaved PARP using western blot assay. +lncRNA target 31115502 hsa-mir-338 Adenocarcinoma of Lung Together, the data of the present study support that miR3383p inhibits lung cancer cell invasion and proliferation by downregulating AKT/betacatenin signaling pathway. +genetics_knock down_promote 31115495 hsa-mir-34a Carcinoma, Hepatocellular In addition, knockdown of miR34a in HCC cells significantly suppressed the synergistic effects of LIUSDDP treatment. +transcription factor target 31115390 hsa-mir-183c Asthma CONCLUSIONS Our results suggest that the therapeutic effects of DHA on asthma are partially realized via the regulation of miR-183C and IL-6/Stat3 pathway. +lncRNA target 31115237 hsa-mir-29a Carcinoma, Hepatocellular CONCLUSIONS: miR-29a-3p participates in the HCC progression by regulation of NF-kappaB pathway via targeting PTEN. +circulation_biomarker_diagnosis_ns 31115212 hsa-mir-133a Colorectal Neoplasms RESULTS Plasma levels of 7 miRNAs (miR-18a, miR-20a, miR-21, miR-92a, miR-133a, miR-143, miR-145) differed significantly between CRC patients and neoplasm free controls. +circulation_biomarker_diagnosis_ns 31115212 hsa-mir-21 Colorectal Neoplasms RESULTS Plasma levels of 7 miRNAs (miR-18a, miR-20a, miR-21, miR-92a, miR-133a, miR-143, miR-145) differed significantly between CRC patients and neoplasm free controls. +circulation_biomarker_diagnosis_ns 31115212 hsa-mir-92a Colorectal Neoplasms RESULTS Plasma levels of 7 miRNAs (miR-18a, miR-20a, miR-21, miR-92a, miR-133a, miR-143, miR-145) differed significantly between CRC patients and neoplasm free controls. +circulation_biomarker_diagnosis_ns 31115212 hsa-mir-145 Colorectal Neoplasms RESULTS Plasma levels of 7 miRNAs (miR-18a, miR-20a, miR-21, miR-92a, miR-133a, miR-143, miR-145) differed significantly between CRC patients and neoplasm free controls. +circulation_biomarker_diagnosis_ns 31115212 hsa-mir-143 Colorectal Neoplasms RESULTS Plasma levels of 7 miRNAs (miR-18a, miR-20a, miR-21, miR-92a, miR-133a, miR-143, miR-145) differed significantly between CRC patients and neoplasm free controls. +circulation_biomarker_diagnosis_ns 31115212 hsa-mir-18a Colorectal Neoplasms RESULTS Plasma levels of 7 miRNAs (miR-18a, miR-20a, miR-21, miR-92a, miR-133a, miR-143, miR-145) differed significantly between CRC patients and neoplasm free controls. +circulation_biomarker_diagnosis_ns 31115212 hsa-mir-20a Colorectal Neoplasms RESULTS Plasma levels of 7 miRNAs (miR-18a, miR-20a, miR-21, miR-92a, miR-133a, miR-143, miR-145) differed significantly between CRC patients and neoplasm free controls. +other 31115130 hsa-mir-210 Eclampsia These findings suggested that miR-210 might act as a contributor to trophoblast dysfunction by attenuating NOTCH1 expression. +circulation_biomarker_prognosis_up 31115097 hsa-mir-125a Sepsis METHODS: A hundred and twenty-six sepsis patients and 125 healthy controls were recruited, and then, blood samples were collected, and plasma was separated for lnc-ANRIL, miR-125a, lnc-ANRIL/miR-125a axis, and inflammatory cytokine level detections. +lncRNA target 31115025 hsa-mir-221 Myocardial Reperfusion Injury Therefore, microRNA-221 might be a potential therapeutic target for myocardial ischemia-reperfusion injury. +lncRNA target 31115018 hsa-mir-17 Spinal Cord Injuries 5p-inhibitor sh-VEGF-A group. +genetics_overexpression_suppress 31115015 hsa-mir-431 Melanoma Functional studies showed that miR-431 down-regulation inhibited melanoma growth and metastasis in vitro, while its overexpression has the opposite effects. +other 31115013 hsa-mir-27a Lung Neoplasms The aim of our study was to analyze the expression of miRNA-27a-3p, miRNA-31, miRNA-182, miRNA-195 with the ability to reciprocal regulation of Dicer and Drosha expression in lung cancer patients. +other 31115013 hsa-mir-195 Lung Neoplasms The aim of our study was to analyze the expression of miRNA-27a-3p, miRNA-31, miRNA-182, miRNA-195 with the ability to reciprocal regulation of Dicer and Drosha expression in lung cancer patients. +other 31115013 hsa-mir-182 Lung Neoplasms The aim of our study was to analyze the expression of miRNA-27a-3p, miRNA-31, miRNA-182, miRNA-195 with the ability to reciprocal regulation of Dicer and Drosha expression in lung cancer patients. +other 31115013 hsa-mir-1 Lung Neoplasms The aim of our study was to analyze the expression of miRNA-27a-3p, miRNA-31, miRNA-182, miRNA-195 with the ability to reciprocal regulation of Dicer and Drosha expression in lung cancer patients. +other 31115013 hsa-mir-27 Lung Neoplasms The aim of our study was to analyze the expression of miRNA-27a-3p, miRNA-31, miRNA-182, miRNA-195 with the ability to reciprocal regulation of Dicer and Drosha expression in lung cancer patients. +transcription factor target 31115009 hsa-mir-4513 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: Our results suggested the oncogenic role of miR-4513 in OSCC, and therefore it might be used as a target for the OSCC treatment. +genetics_knock down_suppress 31115007 hsa-mir-142 Nasopharyngeal Carcinoma Finally, Western blot results demonstrated that the microRNA-142 knockdown inhibited the PI3K/AKT pathway in NPC cells. +other 31115006 hsa-mir-375 Esophageal Squamous Cell Carcinoma CONCLUSIONS: miR-503 was highly expressed in esophageal squamous cell carcinoma and miR-375 was lowly expressed in esophageal squamous cell carcinoma. +lncRNA target 31115005 hsa-mir-421 esophagus adenocarcinoma The predicted regulatory network of miR-421 in ESAD includes both tumor suppressors and oncogenes, which makes the role of miR-421 quite mysterious in this cancer. +genetics_overexpression_promote 31115004 hsa-mir-105 Stomach Neoplasms Finally, overexpression of SOX9 partially reversed the influence of miR-105 on the growth and aggressiveness of gastric carcinoma cell. +lncRNA target 31115003 hsa-mir-195 Stomach Neoplasms CONCLUSIONS: The down-regulation of miR-195 induces the resistance to 5-FU in gastric cancer through promoting the expression of HMGA1. +lncRNA target 31115001 hsa-mir-206 Colorectal Neoplasms FMNL2 was a target for miR-206 in CRC cells. CONCLUSIONS: LINC00707 was up-regulated in CRC tissues and cells, which promoted cell proliferation and metastasis via sponging miR-206 to increase FMNL2 expression. +genetics_overexpression_promote 31114998 hsa-mir-376a Carcinoma, Renal Cell The overexpression of miR-376a inhibits RCC cell proliferation, migration, and invasion through regulating SGK3. +genetics_overexpression_promote 31114997 hsa-mir-1294 Carcinoma, Renal Cell The overexpression of HOXA6 attenuated the miR +transcription factor target 31114995 hsa-mir-572 Wilms Tumor CONCLUSIONS: MiR-572 targeted CDH1 to promote cell metastasis in WT by suppressing EMT. +other 31114993 hsa-mir-34a Prostatic Neoplasms Bioinformatics methods and luciferase reporter assay revealed the close link within miR-34a and 3'-untranslated region (UTR) of LINC00662 and further confirmed that LINC00662 could function as a sponge of miR-34a in PCa cells. +lncRNA target 31114990 hsa-mir-216b Uterine Cervical Neoplasms CONCLUSIONS: Our findings revealed a novel molecular mechanism underlying LINC00152 modulating CC progression through the miR-216b-5p/HOXA1 pathway, suggesting that LINC00152 might potentially act as an effective diagnostic marker and therapeutic target for cervical cancer. +lncRNA target 31114989 hsa-mir-222 Uterine Cervical Neoplasms At the same time, we found that miR-221 and miR-222, which targeted MBD2, were upregulated in cervical cancer samples. +lncRNA target 31114989 hsa-mir-221 Uterine Cervical Neoplasms At the same time, we found that miR-221 and miR-222, which targeted MBD2, were upregulated in cervical cancer samples. +lncRNA target 31114988 hsa-mir-132 Ovarian Neoplasms OBJECTIVE: To explore the role of micro ribonucleic acid-132 (miR-132) in cisplatin (DDP) resistance and metastasis of ovarian cancer and its related mechanisms. CONCLUSIONS: MiR-132 may regulate ovarian cancer's sensitivity to DDP and inhibit its invasion and metastasis by targeted regulation on Bmi-1. +lncRNA target 31114987 hsa-mir-655 Ovarian Neoplasms 3p played a tumor suppressor role in OC. +lncRNA target 31114983 hsa-mir-125a Leukemia, Myeloid, Acute CONCLUSIONS: MicroRNA-125a inhibits proliferative and invasive potentials, arrests the cell cycle in the G2/M phase of AML cells by regulating the NF-kappaB pathway. +transcription factor target 31114980 hsa-mir-17 Retinal Diseases CONCLUSIONS Inhibition of miR5p up-regulates the expression of VEGF-A and GDNF in MSCs, and promotes the repair of spinal cord injury by MSCs. +transcription factor target 31114980 hsa-mir-17 Diabetes Mellitus CONCLUSIONS Inhibition of miR5p up-regulates the expression of VEGF-A and GDNF in MSCs, and promotes the repair of spinal cord injury by MSCs. +other 31114978 hsa-mir-152 Pre-Eclampsia CONCLUSIONS: The expression of miR-152 is increased in the placental tissues of PE rats, and it is positively correlated with VEGF. +circRNA target 31114952 hsa-mir-4493 Glioma At the same time, the expression of miR-4493 was downregulated in glioma cells and had multiple binding sites on the circ-ZNF264 sequence. Therefore, in glioma cells, circ-ZNF264 can inhibit the function of miR-4493 and then upregulate its target gene apelin expression, thus regulating glioma cell proliferation, apoptosis, and invasion. +other 31114934 hsa-mir-142 Carcinoma, Endometrioid In conclusion, we unraveled the oncogenic properties of FAM98A in endometrial carcinoma and highlighted the miR3p-FAM98A signaling in this disease. +other 31114845 hsa-mir-133a Hypertrophy MicroRNA-133a (miR-133a), with a prior well-recognized role in cardiac hypertrophy, was highly enriched in the fraction of circSlc8a1 pull-down (adjusted P-value < 0.001). +other 31114845 hsa-mir-133 Hypertrophy MicroRNA-133a (miR-133a), with a prior well-recognized role in cardiac hypertrophy, was highly enriched in the fraction of circSlc8a1 pull-down (adjusted P-value < 0.001). +other 31114576 hsa-mir-21 Wasting Disease, Chronic Moreover, THC/SIV rhesus macaques failed to upregulate pro-inflammatory miR-21, miR-141 and miR-222, and alpha/beta-defensins, suggesting attenuated intestinal inflammation. +other 31114576 hsa-mir-222 Wasting Disease, Chronic Moreover, THC/SIV rhesus macaques failed to upregulate pro-inflammatory miR-21, miR-141 and miR-222, and alpha/beta-defensins, suggesting attenuated intestinal inflammation. +other 31114576 hsa-mir-141 Wasting Disease, Chronic Moreover, THC/SIV rhesus macaques failed to upregulate pro-inflammatory miR-21, miR-141 and miR-222, and alpha/beta-defensins, suggesting attenuated intestinal inflammation. +lncRNA target 31114485 hsa-mir-23a Epilepsy, Temporal Lobe Our findings suggest that miR-23a targeting of ADAM10 contributes to epileptogenesis in temporal lobe epilepsy. +other 31114448 hsa-mir-199a Carcinoma, Renal Cell CONCLUSION: Our data uncovered a crucial role of SNHG12-miR-199a-5p-HIF1alpha axis in human renal cancer. +other 31114438 hsa-mir-29a ankylosing spondylitis 1 CONCLUSIONS: MiR-29a might be a useful marker in AS new bone formation and contributes to the regulation of Dkk-1 in Wnt signalling. +lncRNA target 31114379 hsa-mir-181c Carcinoma, Hepatocellular Materials and methods: Samples of tumor tissues and adjacent non-tumor tissues were collected from 52 patients with HCC, and expression levels of miR-181c in these samples were investigated via quantitative real-time polymerase chain reaction. +other 31114371 hsa-mir-18a Nasopharyngeal Carcinoma Conclusion: The expression levels of TEP miR-34c-3p and miR-18a-5p are upregulated in NPC, rendering a significant clinical value for NPC diagnosis. +other 31114371 hsa-mir-34c Nasopharyngeal Carcinoma Conclusion: The expression levels of TEP miR-34c-3p and miR-18a-5p are upregulated in NPC, rendering a significant clinical value for NPC diagnosis. +lncRNA target 31114367 hsa-mir-125b esophagus adenocarcinoma Additionally, 12 DEMs were predicted through miRTarBase to be associated with the key genes, and TP53-(miR-125b)-ID2 and JUN-(miR-30a)-IL1A from the TF-miRNA-mRNA network were identified to potentially play significant roles in EAC. +genetics_overexpression_promote 31114353 hsa-mir-526b Glioma Functional investigation indicated that overexpression of miR-526b-3p suppressed cell proliferation, migration, and invasion, and promoted apoptosis in glioma cell lines. +other 31114344 hsa-mir-34a Carcinoma, Hepatocellular Survival analyses showed that HCC patients with either high miR-34a, or low E2F1, or low E2F3 expression had better survival than their opposite counterparts, respectively. +transcription factor target 31114250 hsa-mir-145 Glioblastoma Conclusion: MiR-145 inhibits EGF-induced EMT via targeting Smad2 in human GBM. +genetics_overexpression_suppress 31114243 hsa-mir-216b Carcinoma, Non-Small-Cell Lung MiR-216b overexpression remarkably repressed cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of NSCLC cells. +genetics_overexpression_promote 31114240 hsa-mir-100 Squamous Cell Carcinoma of Head and Neck 5p, overexpression led to inhibited proliferation, migration and invasion of LSCC cells. +genetics_overexpression_promote 31114240 hsa-mir-204 Squamous Cell Carcinoma of Head and Neck 5p, overexpression led to inhibited proliferation, migration and invasion of LSCC cells. +transcription factor target 31114229 hsa-mir-940 Colorectal Neoplasms MiR-940 also enhanced the inhibitory effect of Anlotinib on CRC cells' in vivo growth and invasion. +other 31114220 hsa-mir-16 Glioma The regulatory cascade LINC00515/miR-16/PRMT5 plays a critical role in glioma progression. +lncRNA target 31114219 hsa-mir-216a Glioma Furthermore, suppression of miR-216a increased accumulation of LGR5, PI3K, AKT, and p-AKT in glioma cells transfected with DANCR-targeting siRNA. +lncRNA target 31114192 hsa-mir-326 Carcinoma, Endometrioid Conclusion: Collectively, we confirmed that SPIONs are highly efficient nanocarriers for nucleic acids, on which the loading of miR-326 inhibited the activation of the GPR91/STAT3/VEGF signaling pathway and significantly attenuated the activity of stem cells in endometrial carcinoma, both in vitro and in vivo. +transcription factor target 31113580 hsa-mir-182 Non-alcoholic Fatty Liver Disease 5p ameliorated HFD-induced NASH by suppressing TLR4. +circulation_biomarker_diagnosis_ns 31113311 hsa-mir-133a Muscular Diseases Increases in plasma levels of creatine phosphokinase, myoglobin, miR-1, and miR-133a and degeneration/necrosis of myofibers in skeletal muscles but not in the heart were observed in LV- and FF-coadministered dogs. +circulation_biomarker_diagnosis_ns 31113311 hsa-mir-1 Muscular Diseases Increases in plasma levels of creatine phosphokinase, myoglobin, miR-1, and miR-133a and degeneration/necrosis of myofibers in skeletal muscles but not in the heart were observed in LV- and FF-coadministered dogs. +lncRNA target 31113203 hsa-mir-34a Osteoarthritis CONCLUSION: miRNA-34a could induce osteoarthritis synovial cell apoptosis via regulation of TGIF2 in vitro (Fig. +other 31113196 hsa-mir-335 Hyperlipidemias Also, miR-370, miR-378, miRa and miR-335 might aid in the identification of new therapies to treat patients with primary hyperlipidemia (Tab. +other 31113196 hsa-mir-378a Hyperlipidemias Also, miR-370, miR-378, miRa and miR-335 might aid in the identification of new therapies to treat patients with primary hyperlipidemia (Tab. +other 31113196 hsa-mir-370 Hyperlipidemias Also, miR-370, miR-378, miRa and miR-335 might aid in the identification of new therapies to treat patients with primary hyperlipidemia (Tab. +other 31113196 hsa-mir-378 Hyperlipidemias Also, miR-370, miR-378, miRa and miR-335 might aid in the identification of new therapies to treat patients with primary hyperlipidemia (Tab. +other 31113196 hsa-mir-27a Hyperlipidemias Also, miR-370, miR-378, miRa and miR-335 might aid in the identification of new therapies to treat patients with primary hyperlipidemia (Tab. +genetics_overexpression_promote 31112871 hsa-mir-200a Osteoporosis The mRNA levels of Bglap, Runx2 and OPN were downregulated by overexpressed microRNA-200a-3p. +circulation_biomarker_diagnosis_down 31112271 hsa-mir-143 Pituitary Neoplasms Plasma miR +genetics_overexpression_promote 31111958 hsa-mir-146a Breast Neoplasms Here, we show that the histone deacetylase inhibitor, trichostatin A (TSA), suppresses HER2-overexpressing breast cancer via upregulation of miR-146a and the resultant repression of its oncogenic targets, interleukin-1 receptor-associated kinase 1 and the chemokine receptor CXCR4. +genetics_overexpression_promote 31111550 hsa-mir-4286 Carcinoma, Non-Small-Cell Lung Our study suggests that miR-4286 overexpression represents a tumor promoter role in NSCLC cells. +genetics_overexpression_suppress 31111544 hsa-mir-628 Glioma Second, overexpressing miR +lncRNA target 31111526 hsa-mir-200b Prostatic Neoplasms Finally, Western blot assay was used to validate the regulation of CUL4B, miR200b, and miR200c (miR200b/c) on the stem-like characteristics of PCa cells. CONCLUSIONS: Our study revealed that CUL4B regulates cancer stem-like traits of prostate cancer cells by targeting BMI1 via miR200b/c, which might give novel insight into how CUL4B promotes PCa progression through regulating cancer stem-like traits. +lncRNA target 31111481 hsa-mir-200c Stomach Neoplasms The purpose of this study was to explore the potential function and mechanism of miR-200c and cisplatin in the inhibition of migration and induction of apoptosis in gastric cancer cells. +tissue_expression_ns 31111446 hsa-mir-20a Acquired Immunodeficiency Syndrome 3p hold potential as biomarkers for gestational diabetes mellitus (GDM) in human immunodeficiency virus (HIV)-negative South African women. +tissue_expression_ns 31111446 hsa-mir-222 Diabetes, Gestational 3p hold potential as biomarkers for gestational diabetes mellitus (GDM) in human immunodeficiency virus (HIV)-negative South African women. +tissue_expression_ns 31111446 hsa-mir-222 Acquired Immunodeficiency Syndrome 3p hold potential as biomarkers for gestational diabetes mellitus (GDM) in human immunodeficiency virus (HIV)-negative South African women. +tissue_expression_ns 31111446 hsa-mir-20a Diabetes, Gestational 3p hold potential as biomarkers for gestational diabetes mellitus (GDM) in human immunodeficiency virus (HIV)-negative South African women. +circulation_biomarker_diagnosis_up 31111286 hsa-mir-501 Osteosarcoma 5p in peripheral blood of OS patients were tumor-derived. +circulation_biomarker_diagnosis_up 31111286 hsa-mir-493 Osteosarcoma 5p in peripheral blood of OS patients were tumor-derived. +circulation_biomarker_diagnosis_up 31111286 hsa-mir-487a Osteosarcoma 5p in peripheral blood of OS patients were tumor-derived. +circulation_biomarker_diagnosis_up 31111286 hsa-mir-502 Osteosarcoma 5p in peripheral blood of OS patients were tumor-derived. +transcription factor target 31111062 hsa-mir-455 Prostatic Neoplasms 5p suppressed PCa cellular proliferation and induced cell apoptosis by downregulating CCR5. +lncRNA target 31109967 hsa-mir-582 Colorectal Neoplasms Hsa_circ_0009361 acted as a tumor suppressive sponge of miR-582, which could up-regulate the expression of APC2, inhibit the Wnt/beta-catenin signaling, and suppress the growth and metastasis of CRC. +other 31109699 hsa-mir-92a Squamous Cell Carcinoma of Head and Neck The expression levels of selected miRNAs (miR-199b-5p, miR-29c-3p, miR5p, miR-125b-5p and miR-92a-3p) and genes (COL3A1, COL10A1, ERBB4, HMGA2, HLF, TOP2A, MMP3, MMP13, MMP10 and PPP1R3) were confirmed as altered in LSCC by RT-qPCR. +other 31109699 hsa-mir-29c Squamous Cell Carcinoma of Head and Neck The expression levels of selected miRNAs (miR-199b-5p, miR-29c-3p, miR5p, miR-125b-5p and miR-92a-3p) and genes (COL3A1, COL10A1, ERBB4, HMGA2, HLF, TOP2A, MMP3, MMP13, MMP10 and PPP1R3) were confirmed as altered in LSCC by RT-qPCR. +other 31109440 hsa-mir-148b Adenocarcinoma of Lung CONCLUSIONS MiR-148b-3p was significantly associated with tumor grade and tumor size in lung adenocarcinoma, and served as an independent predictor of overall survival of patients with lung adenocarcinoma. +lncRNA target 31109400 hsa-mir-363 Endometrial Neoplasms The results demonstrated that NR2F1-AS1 was highly expressed in EC, which involved in the proliferation and migration of EC cells through downregulation of miR-363 to target SOX4 and regulating PI3K/AKT/GSK-3(beta) pathway. +lncRNA target 31109274 hsa-mir-137 Diabetes, Gestational CONCLUSIONS: The data from the present study suggest that miR-137 suppresses the viability and migration of trophoblasts via downregulating FNDC5 in GDM, which may contribute to the pathology of placenta tissues and occurrence of adverse pregnancy outcomes. +circulation_biomarker_diagnosis_ns 31109008 hsa-mir-1 Diabetes Mellitus, Type 2 To investigate whether the circulating miR-1 (microRNA-1) and miR-21 expression might be used in the diagnosis of heart failure (HF) and silent coronary artery disease (SCAD) in asymptomatic type 2 diabetes mellitus (T2DM) patients and to explore the relationship of these miRs with N-terminal pro-brain natriuretic peptide (NT-proBNP) and galectin-3. +circulation_biomarker_diagnosis_ns 31109008 hsa-mir-1 Heart Failure, Acute To investigate whether the circulating miR-1 (microRNA-1) and miR-21 expression might be used in the diagnosis of heart failure (HF) and silent coronary artery disease (SCAD) in asymptomatic type 2 diabetes mellitus (T2DM) patients and to explore the relationship of these miRs with N-terminal pro-brain natriuretic peptide (NT-proBNP) and galectin-3. +genetics_overexpression_promote 31109008 hsa-mir-21 Diabetes Mellitus, Type 2 Similarly, miR-21 was overexpressed in patients with DM, CAD DM, and HF DM with 1.30, 1.79 and 2.21 fold changes as compared with controls, respectively. +genetics_overexpression_promote 31109008 hsa-mir-21 Heart Failure, Acute Similarly, miR-21 was overexpressed in patients with DM, CAD DM, and HF DM with 1.30, 1.79 and 2.21 fold changes as compared with controls, respectively. +other 31108493 hsa-mir-10a Essential Hypertension Using the interaction of miR-10a-5p in combination with hsa_circ_0126991 led to a sensitivity of 0.708, a specificity of 0.764, and combined area under the curve of 0.774 (95% CI: 0.705-0.843) for early diagnosis of EH. +other 31108351 hsa-mir-3171 Carcinoma, Hepatocellular Mechanistically, circHIAT1 acted as the miR-3171 sponge to upregulate PTEN in HCC. Finally, rescue assays demonstrated the role of circHIAT1/miR-3171/PTEN pathway in regulating HCC cell growth. +other 31108165 hsa-mir-197 Nerve Degeneration Taken together, these results suggest that downregulation of hsa_circ_0068087 ameliorates TLR4/NF-kappaB/NLRP3 inflammasome-mediated inflammation and endothelial cell dysfunction in the high glucose condition by sponging miR-197. +other 31108165 hsa-mir-197 Esophageal Squamous Cell Carcinoma Taken together, these results suggest that downregulation of hsa_circ_0068087 ameliorates TLR4/NF-kappaB/NLRP3 inflammasome-mediated inflammation and endothelial cell dysfunction in the high glucose condition by sponging miR-197. +genetics_overexpression_suppress 31108165 hsa-mir-197 Inflammation It was found that TLR4 was the target of miR-197 and that overexpression of TLR4 ameliorated miR +other 31107971 hsa-mir-218 Prostatic Neoplasms These results establish that lncAPP/miR218 axis plays a critical role in PCa progression, and they also suggest new strategies to prevent tumor progression for therapeutic purposes. +lncRNA target 31106896 hsa-mir-27a Pancreatitis To investigate the apoptosis and inflammatory response of microRNA-27a-5p (miR-27a-5p) in pancreatic acinar cells of acute pancreatitis (AP) and its related mechanisms. miR-27a-5p induced apoptosis and inhibited the inflammatory response of pancreatic acinar cells in AP by targeting PTEN. +lncRNA target 31106881 hsa-mir-92b Stomach Neoplasms To investigate the effect and mechanism of microRNA-92b-3p (miR-92b-3p) targeting Homeobox D10 (HOXD10) on proliferation, migration, and invasion of gastric cancer, we detected the expression of miR-92b-3p and HOXD10 in SGC-7901 cells. In conclusion, miR-92b-3p is highly expressed in gastric cancer SGC-7901 cells, and interfering with its expression might inhibit SGC-7901 cell proliferation, migration, and invasion via downregulating MMP-2/9 expression and targeting HOXD10. +lncRNA target 31106680 hsa-mir-208a Osteosarcoma CONCLUSIONS In our study, long noncoding RNA steroid receptor RNA activator 1 played an antitumor role in osteosarcoma as it reduced cell migration, invasion, and proliferation, but facilitated cell apoptosis via sponging microRNA-208a, which could be regarded as a potential therapeutic target of osteosarcoma treatment. +lncRNA target 31106658 hsa-mir-122 Cholangiocarcinoma LncRNA-UCA1 promoted the metastasis of BDC cells by regulating the expression of miR-122 and its downstream gene mRNA CLIC1 and promoted the activation of the ERK/MAPK pathway, which expanded the horizons of targeted therapy of cholangiocarcinoma. +epigenetics 31106536 hsa-mir-148a Lung Neoplasms OBJECTIVE: To study the effect of methylation level of microRNA promoter on the expression of microRNAs (miRNA34a, miRNA34b, miRNA148a, miRNA203a) and on the proliferation, migration and invasion of lung cancer A549 cells. CONCLUSION: 5-Aza-CdR can reverse methylation levels of miRNAs promoter regions and upregulate the expression level of miRNA34a, miRNA34b, miRNA148a, miRNA203a, resulting in significantly inhibiting the proliferation, migration and invasion of lung cancer cells. +epigenetics 31106536 hsa-mir-34a Lung Neoplasms OBJECTIVE: To study the effect of methylation level of microRNA promoter on the expression of microRNAs (miRNA34a, miRNA34b, miRNA148a, miRNA203a) and on the proliferation, migration and invasion of lung cancer A549 cells. CONCLUSION: 5-Aza-CdR can reverse methylation levels of miRNAs promoter regions and upregulate the expression level of miRNA34a, miRNA34b, miRNA148a, miRNA203a, resulting in significantly inhibiting the proliferation, migration and invasion of lung cancer cells. +epigenetics 31106536 hsa-mir-34b Lung Neoplasms OBJECTIVE: To study the effect of methylation level of microRNA promoter on the expression of microRNAs (miRNA34a, miRNA34b, miRNA148a, miRNA203a) and on the proliferation, migration and invasion of lung cancer A549 cells. CONCLUSION: 5-Aza-CdR can reverse methylation levels of miRNAs promoter regions and upregulate the expression level of miRNA34a, miRNA34b, miRNA148a, miRNA203a, resulting in significantly inhibiting the proliferation, migration and invasion of lung cancer cells. +epigenetics 31106536 hsa-mir-203a Lung Neoplasms OBJECTIVE: To study the effect of methylation level of microRNA promoter on the expression of microRNAs (miRNA34a, miRNA34b, miRNA148a, miRNA203a) and on the proliferation, migration and invasion of lung cancer A549 cells. CONCLUSION: 5-Aza-CdR can reverse methylation levels of miRNAs promoter regions and upregulate the expression level of miRNA34a, miRNA34b, miRNA148a, miRNA203a, resulting in significantly inhibiting the proliferation, migration and invasion of lung cancer cells. +lncRNA target 31106532 hsa-mir-185 Lung Neoplasms OBJECTIVE To investigate the effect on -Catenin pathway by lncRNA urothelial carcinoma associated 1 (UCA1) targeting regulated miR5p in human lung adenocarcinoma A549 cell line. +lncRNA target 31106532 hsa-mir-185 Carcinoma, Non-Small-Cell Lung OBJECTIVE To investigate the effect on -Catenin pathway by lncRNA urothelial carcinoma associated 1 (UCA1) targeting regulated miR5p in human lung adenocarcinoma A549 cell line. +lncRNA target 31106468 hsa-mir-202 Breast Neoplasms CONCLUSIONS: miR-202 inhibited breast cancer cells proliferation, invasion, and migration by targeting the ROCK1 gene. +genetics_overexpression_promote 31106423 hsa-mir-221 Glioblastoma miR-221 and miR-222 were overexpressed or silenced in glioblastoma cells to identify the effect of miR-221/222 cluster in cell invasion, migration, proliferation, and angiogenesis. +genetics_overexpression_promote 31106423 hsa-mir-222 Glioblastoma miR-221 and miR-222 were overexpressed or silenced in glioblastoma cells to identify the effect of miR-221/222 cluster in cell invasion, migration, proliferation, and angiogenesis. +other 31106421 hsa-mir-140 Carcinoma, Non-Small-Cell Lung Mechanistic investigations revealed LINC01234 promotes the progression of NSCLC cells by the modulation of miR-140 to positively regulate OTUB1 expression. +genetics_overexpression_promote 31105995 hsa-mir-874 Rhabdomyosarcoma Downregulation of GEFT has similar effects to miR-874 overexpression in RMS cells. +other 31105852 hsa-mir-375 Stomach Neoplasms Taken together, these findings are evidence that circRNA hsa_circ_0008035 promotes gastric cancer cell proliferation and invasion by regulating miR-375/YBX1. +lncRNA target 31105850 hsa-mir-501 Hemangioma It was also demonstrated HOXD10 downregulation reversed the effects of the miR-501 inhibitor on hemangioma cell activities. +lncRNA target 31105849 hsa-mir-4513 Breast Neoplasms Taken together, our results suggested miR-4513 functions as an oncogene in the progression of BC and, therefore, miR-4513 may be validated as a potential therapeutic target in the future. +other 31105847 hsa-mir-222 Carcinoma, Endometrioid In conclusion, these results confirmed the vital regulation of GAS5/miR3p/p27 axis in the endometrial carcinoma tumorigenesis. +transcription factor target 31105840 hsa-mir-21 Pre-Eclampsia The result of the present study suggests that miR-21 may prove to be a new target for the diagnosis and treatment of preeclampsia and other cardiovascular diseases. +lncRNA target 31105834 hsa-mir-132 Endometriosis These data defined LINC00261/miR3p/BCL2L11 regulatory networks may be a novel therapeutic target for endometriosis. +transcription factor target 31105832 hsa-mir-186 Neuroblastoma 5p could inhibit tumor proliferation by targeting Eg5 in neuroblastoma. +lncRNA target 31105831 hsa-mir-495 Osteoarthritis Therefore, miR-495 may be a prospective target for OA treatment. +genetics_overexpression_promote 31105829 hsa-mir-378a Carcinoma, Renal Cell Functional studies in two RCC cell lines (ACHN and 786-O) have indicated that miR-378a-5p overexpression attenuated cell proliferation, migration, and invasion while promoting cell apoptosis. +genetics_knock down_promote 31105827 hsa-mir-590 Liver Neoplasms 5p in 5-Fu resistant patients and liver cancer cells, and knockdown of miR +lncRNA target 31105811 hsa-mir-424 Reperfusion Injury, Renal Ischemia We established that, up-regulation of miR-424 in ischemic reperfusion injury was p53 dependent, also inhibition of p53 caused repression of miR-424 levels in hypoxia induced cells in vitro. CONCLUSION: The study confirmed p53/miR-424/DR6 as a protective cascade during ischemic-reperfusion injury. +genetics_overexpression_promote 31105794 hsa-mir-185 Carcinoma, Hepatocellular 5p overexpression impeded migration and invasion of HCC cells. +genetics_knock down_promote 31105792 hsa-mir-765 Multiple Myeloma Furthermore, SOX6 knockdown markedly abrogated the effects of miR-765 underexpression on cell proliferation and apoptosis in MM. +lncRNA target 31105788 hsa-mir-10b Glioma In addition, the expression of proteins associated with migration and invasion, including HMGB1, RhoC and MMP2, was upregulated in glioma cells transfected with miR-10b-5p mimic, while these proteins were downregulated in cells transfected with miR-10b-5p inhibitor. +circulation_biomarker_diagnosis_ns 31105742 hsa-mir-223 Adenocarcinoma of Lung 3p; in EV, the hsa-miR-23b-3p was highly expressed in granuloma patients but not lung adenocarcinoma patients; in EV-free plasma, hsa-miR-376a-3p was expressed in granuloma patients but barely expressed in lung adenocarcinoma patients. +circulation_biomarker_diagnosis_ns 31105742 hsa-mir-23b Adenocarcinoma of Lung 3p; in EV, the hsa-miR-23b-3p was highly expressed in granuloma patients but not lung adenocarcinoma patients; in EV-free plasma, hsa-miR-376a-3p was expressed in granuloma patients but barely expressed in lung adenocarcinoma patients. +circulation_biomarker_diagnosis_ns 31105742 hsa-mir-376a Adenocarcinoma of Lung 3p; in EV, the hsa-miR-23b-3p was highly expressed in granuloma patients but not lung adenocarcinoma patients; in EV-free plasma, hsa-miR-376a-3p was expressed in granuloma patients but barely expressed in lung adenocarcinoma patients. +genetics_overexpression_suppress 31104928 hsa-mir-208a Ovarian Neoplasms Elevated expression of miR-208a-5p inhibited the migration and invasion of OVCAR-3 cell which can be rescued by DAAM1 overexpression. +transcription factor target 31104336 hsa-mir-219 Carcinoma, Hepatocellular Furthermore, the underlying mechanism investigations of the suppressive effects of propofol on HCC cells revealed that propofol treatment upregulated the expression levels of the candidate tumour suppressor miR +transcription factor target 31104329 hsa-mir-152 Prostatic Neoplasms 3p/152-3p family could serve as tumor suppressors in PCa via repressing KLF4. +transcription factor target 31104329 hsa-mir-148 Prostatic Neoplasms 3p/152-3p family could serve as tumor suppressors in PCa via repressing KLF4. +genetics_overexpression_promote 31104318 hsa-mir-195 Stomach Neoplasms Overall, these findings revealed that ELK1-induced overexpression of TRPM2-AS promoted the development and progression of GC in part through miR-195/HMGA1 signaling axis, and established its candidacy as a new cancer biomarker for GC patients. +other 31104300 hsa-mir-15a Rhinitis, Allergic MiR-15a-5p has been proved to be involved in AR immune response as the upstream regulator of ADRB2. +genetics_overexpression_suppress 31103821 hsa-mir-23b Cardiomegaly miR-23b-5p overexpression in vivo aggravated pressure overload-induced cardiac hypertrophy and dysfunction, whereas the miR-inhibitor increased HMGB2 expression and reversed these effects. +other 31103631 hsa-mir-449b Uterine Cervical Neoplasms In summary, miR-449b-5p interacted with FOXP1 to regulate cell proliferation, migration, invasion and radiosensitivity in CC. +lncRNA target 31103262 hsa-mir-19a Osteosarcoma Therefore, circ_ORC2 binds with miR-19a and enhances its expression, thereby inhibiting downstream PTEN expression and activating Akt pathway to promote osteosarcoma cell growth and invasion. +other 31103022 hsa-mir-15a Stomach Neoplasms CONCLUSION: This study provides evidence for deregulated expression of miR155-5p, miR-186, and miR-15a in GC and is providing new insights into the potential implication of these miRNAs in the pathogenesis of GC. +other 31103022 hsa-mir-155 Stomach Neoplasms CONCLUSION: This study provides evidence for deregulated expression of miR155-5p, miR-186, and miR-15a in GC and is providing new insights into the potential implication of these miRNAs in the pathogenesis of GC. +other 31103022 hsa-mir-15b Stomach Neoplasms METHODS: For this research, we used qPCR to investigate miR-15b, miR-155, miR-15a, and miR-186 expression levels in a total of 29 normal gastric tissue, 45 gastric dysplasia, and 39 GC samples. +other 31103022 hsa-mir-186 Stomach Neoplasms CONCLUSION: This study provides evidence for deregulated expression of miR155-5p, miR-186, and miR-15a in GC and is providing new insights into the potential implication of these miRNAs in the pathogenesis of GC. +genetics_knock down_suppress 31102936 hsa-mir-128 Thyroid Carcinoma, Anaplastic These findings suggested that knockdown of HCP5 exerted anti-tumor effect via sponging miR +other 31102912 hsa-mir-21 Spinal Cord Injuries The data suggest that modulation of the MSCs-EVs miR5p/FasL gene axis may serve as a promising strategy for clinical treatment of SCI and other neurological diseases. +circulation_biomarker_diagnosis_ns 31102419 hsa-mir-20a Multiple Myeloma The levels of serum exosome-derived miR-20a-5p, miR-103a-3p, and miR-4505 were significantly different among patients with MM, patients with SMM, and healthy individuals, while there were differences in the levels of let-7c-5p, miR5p, and miR-4741 in patients with MM relative to those in SMM patients or healthy controls. +circulation_biomarker_diagnosis_ns 31102419 hsa-mir-103a Multiple Myeloma The levels of serum exosome-derived miR-20a-5p, miR-103a-3p, and miR-4505 were significantly different among patients with MM, patients with SMM, and healthy individuals, while there were differences in the levels of let-7c-5p, miR5p, and miR-4741 in patients with MM relative to those in SMM patients or healthy controls. +circulation_biomarker_diagnosis_ns 31102419 hsa-mir-185 Multiple Myeloma The levels of serum exosome-derived miR-20a-5p, miR-103a-3p, and miR-4505 were significantly different among patients with MM, patients with SMM, and healthy individuals, while there were differences in the levels of let-7c-5p, miR5p, and miR-4741 in patients with MM relative to those in SMM patients or healthy controls. +circulation_biomarker_diagnosis_ns 31102419 hsa-mir-4741 Multiple Myeloma The levels of serum exosome-derived miR-20a-5p, miR-103a-3p, and miR-4505 were significantly different among patients with MM, patients with SMM, and healthy individuals, while there were differences in the levels of let-7c-5p, miR5p, and miR-4741 in patients with MM relative to those in SMM patients or healthy controls. +circulation_biomarker_diagnosis_ns 31102419 hsa-let-7c Multiple Myeloma The levels of serum exosome-derived miR-20a-5p, miR-103a-3p, and miR-4505 were significantly different among patients with MM, patients with SMM, and healthy individuals, while there were differences in the levels of let-7c-5p, miR5p, and miR-4741 in patients with MM relative to those in SMM patients or healthy controls. +circulation_biomarker_diagnosis_ns 31102419 hsa-mir-4505 Multiple Myeloma The levels of serum exosome-derived miR-20a-5p, miR-103a-3p, and miR-4505 were significantly different among patients with MM, patients with SMM, and healthy individuals, while there were differences in the levels of let-7c-5p, miR5p, and miR-4741 in patients with MM relative to those in SMM patients or healthy controls. +lncRNA target 31102349 hsa-mir-339 Glioma CONCLUSIONS: These data indicated that FOXD1-AS1, a miR339/342 target, affected biological processes via protein eIF5a; thus, it might be considered as a new therapeutic target for glioblastoma. +genetics_overexpression_suppress 31102273 hsa-mir-16 Colorectal Neoplasms Collectively, BMSCs-derived exosomes overexpressing miR +genetics_overexpression_promote 31102265 hsa-mir-7 Osteosarcoma Expression of IGF1R was downregulated in OS cells with overexpression of miR-7. +genetics_overexpression_suppress 31102261 hsa-mir-138 Thyroid Cancer, Papillary The results showed that silenced lncRNA RP11-476D10.1 or overexpressed miR +other 31102171 hsa-let-7g Colorectal Neoplasms Relative expression of seven CRC-related miRNAs (miR-21, miR-31, miR-20a, miR-133b, and miR-145, miR-135b and let-7g) and three CRC-related genes (K-ras, APC, p53) was detected using the SYBR Green quantitative real-time PCR technique. +other 31102171 hsa-mir-21 Colorectal Neoplasms Relative expression of seven CRC-related miRNAs (miR-21, miR-31, miR-20a, miR-133b, and miR-145, miR-135b and let-7g) and three CRC-related genes (K-ras, APC, p53) was detected using the SYBR Green quantitative real-time PCR technique. +other 31102171 hsa-mir-135b Colorectal Neoplasms Relative expression of seven CRC-related miRNAs (miR-21, miR-31, miR-20a, miR-133b, and miR-145, miR-135b and let-7g) and three CRC-related genes (K-ras, APC, p53) was detected using the SYBR Green quantitative real-time PCR technique. +other 31102171 hsa-mir-1 Colorectal Neoplasms Relative expression of seven CRC-related miRNAs (miR-21, miR-31, miR-20a, miR-133b, and miR-145, miR-135b and let-7g) and three CRC-related genes (K-ras, APC, p53) was detected using the SYBR Green quantitative real-time PCR technique. +other 31102171 hsa-mir-133b Colorectal Neoplasms Relative expression of seven CRC-related miRNAs (miR-21, miR-31, miR-20a, miR-133b, and miR-145, miR-135b and let-7g) and three CRC-related genes (K-ras, APC, p53) was detected using the SYBR Green quantitative real-time PCR technique. +other 31102171 hsa-mir-20a Colorectal Neoplasms Relative expression of seven CRC-related miRNAs (miR-21, miR-31, miR-20a, miR-133b, and miR-145, miR-135b and let-7g) and three CRC-related genes (K-ras, APC, p53) was detected using the SYBR Green quantitative real-time PCR technique. +other 31102171 hsa-mir-145 Colorectal Neoplasms Relative expression of seven CRC-related miRNAs (miR-21, miR-31, miR-20a, miR-133b, and miR-145, miR-135b and let-7g) and three CRC-related genes (K-ras, APC, p53) was detected using the SYBR Green quantitative real-time PCR technique. +circulation_biomarker_diagnosis_ns 31102153 hsa-mir-125b Arthritis, Juvenile METHODS In this study, we evaluated the expression of miR-125b in the peripheral blood mononuclear cells (PBMCs) of children with JIA, and the relationship of miR-125b with Th17/Treg imbalance. +other 31101802 hsa-mir-34a Melanoma We demonstrated that miR-34a is negatively correlated with MALAT1 in melanoma cells and tumor specimens. Interestingly, MALAT1, which contains functional sequence-specific miR-34a-binding sites, regulates miR-34a stability in melanoma cells and in vivo. +genetics_knock down_promote 31101765 hsa-mir-450a Ovarian Neoplasms Following glutamine withdrawal, miR-450a overexpression decreased mitochondrial membrane potential but increased glucose uptake and viability, characteristics of less invasive ovarian cancer cell lines. +lncRNA target 31101319 hsa-mir-106b Neurotic Disorders CONCLUSIONS: Our results identify the miR-106b approximately 25 cluster as a key regulator of stress-induced inflammation and depression that may represent a novel therapeutic target for drug development. +genetics_knock down_promote 31101319 hsa-mir-106b Reflex Sympathetic Dystrophy Selective knockout of the miR-106b approximately 25 cluster in peripheral leukocytes promoted behavioral resilience to RSDS. +other 31101319 hsa-mir-25 Reflex Sympathetic Dystrophy Of the miRs profiled in our panel, eight were significantly regulated by RSDS within Ly6c(high) monocytes, including miR3p, a member of the miR-106b approximately 25 cluster. +genetics_overexpression_promote 31101191 hsa-mir-21 Hepatitis B, Chronic In addition, according to multivariate Cox regression analysis, the overexpression of miR-21 was found to be a prognostic indicator in HBV-mediated HCC patients (P = .002). +circRNA target 31101108 hsa-mir-626 Urinary Bladder Neoplasms CONCLUSIONS: circACVR2A functions as a tumor suppressor to inhibit bladder cancer cell proliferation and metastasis through miR-626/EYA4 axis, suggesting that circACVR2A is a potential prognostic biomarker and therapeutic target for bladder cancer. +exosome 31101062 hsa-mir-26a Glioma Based on the role of miR-26a in angiogenesis of glioma, our study was performed to investigate whether glioma stem cells (GSCs)-derived exosomes containing miR-26a could exert effects on angiogenesis of microvessel endothelial cells in glioma, in order to provide a new therapeutic RNA vehicle for glioma therapies. +other 31100777 hsa-mir-27a Myocardial Infarction In the present study, we further investigated the potential function of miR-27a-5p in the cardiomyocyte response to hypoxia, and showed that miR-27a-5p expression was downregulated in the H9c2 cells at different hypoxia-exposed timepoints and the myocardium of a rat AMI model. +lncRNA target 31100777 hsa-mir-27a Hypoxia Follow-up experiments revealed that miR-27a-5p attenuated hypoxia-induced cardiomyocyte injury by regulating autophagy and apoptosis via Atg7, which partly elucidated the anti-hypoxic injury effects of miR-27a-5p. +transcription factor target 31100777 hsa-mir-27a Myocardial Ischemia Taken together, this study shows that miR-27a-5p has a cardioprotective effect on hypoxia-induced H9c2 cell injury, suggesting it may be a novel target for the treatment of hypoxia-related heart diseases. +other 31100679 hsa-mir-1 Colitis-Associated Neoplasms 5p down-stream LATS2 and YAP genes in the hippo pathway were also modulated by the WIR (25mg/kg) treatment. +other 31100644 hsa-mir-223 Abortion, Habitual Furthermore, significant decreased expression levels of FoxP3, miRa and miR-223 was also observed in RPL-MS group. +other 31100644 hsa-mir-223 Metabolic Diseases Furthermore, significant decreased expression levels of FoxP3, miRa and miR-223 was also observed in RPL-MS group. +other 31100644 hsa-mir-146a Abortion, Habitual Furthermore, significant decreased expression levels of FoxP3, miRa and miR-223 was also observed in RPL-MS group. +other 31100644 hsa-mir-146a Metabolic Diseases Furthermore, significant decreased expression levels of FoxP3, miRa and miR-223 was also observed in RPL-MS group. +circulation_biomarker_diagnosis_ns 31100542 hsa-mir-126 psoriasis 1 METHODS: MiRNA-126(MiR-126) expression in plasma was analyzed in psoriasis patients at month 0 (M0), M1, M3 and M6 and in health controls (HCs) at enrollment by qPCR. +other 31100472 hsa-mir-17 idiopathic scoliosis 5p, miR-15a-5p, and miR-181b-5p may play essential roles in AIS pathogenesis and accompanied osteopenia. +other 31100472 hsa-mir-106a idiopathic scoliosis 5p, miR-15a-5p, and miR-181b-5p may play essential roles in AIS pathogenesis and accompanied osteopenia. +other 31100472 hsa-mir-106b idiopathic scoliosis 5p, miR-15a-5p, and miR-181b-5p may play essential roles in AIS pathogenesis and accompanied osteopenia. +other 31100472 hsa-mir-16 idiopathic scoliosis 5p, miR-15a-5p, and miR-181b-5p may play essential roles in AIS pathogenesis and accompanied osteopenia. +transcription factor target 31100367 hsa-mir-187 Reperfusion Injury 3p protected against pain hypersensitivity and mature IL-1beta overproduction, partially through inhibiting P2X7R activation. +transcription factor target 31100367 hsa-mir-187 Neuralgia 3p protected against pain hypersensitivity and mature IL-1beta overproduction, partially through inhibiting P2X7R activation. +other 31099778 hsa-mir-196a-2 Multiple Sclerosis We analyzed the association of polymorphic variants in miRNA genes MIR146A, MIR196A2, and MIR499A with the risk of primary progressive multiple sclerosis one by one and in biallelic combinations with variants of immune-related genes; the analysis was performed in comparison with healthy individuals and with relapsing-remitting multiple sclerosis patients. +other 31099778 hsa-mir-499a Multiple Sclerosis We analyzed the association of polymorphic variants in miRNA genes MIR146A, MIR196A2, and MIR499A with the risk of primary progressive multiple sclerosis one by one and in biallelic combinations with variants of immune-related genes; the analysis was performed in comparison with healthy individuals and with relapsing-remitting multiple sclerosis patients. +other 31099778 hsa-mir-146a Multiple Sclerosis We analyzed the association of polymorphic variants in miRNA genes MIR146A, MIR196A2, and MIR499A with the risk of primary progressive multiple sclerosis one by one and in biallelic combinations with variants of immune-related genes; the analysis was performed in comparison with healthy individuals and with relapsing-remitting multiple sclerosis patients. +genetics_overexpression_promote 31099423 hsa-mir-365 Carcinoma, Non-Small-Cell Lung Poorly expressed miR-365 and overexpressed TRIM25 was found in NSCLC tissues. +transcription factor target 31099182 hsa-mir-891b Enterovirus Infections We discover a new molecular mechanism by which host cells counteract EV71-induced apoptosis through the lnc-IRAK3-3/miR-891b/GADD45beta axis partially. +genetics_overexpression_promote 31099097 hsa-mir-15a Liver Neoplasms Moreover, HOAX11-AS overexpression activated the Janus kinase (JAK)-STAT pathway and thus promoted the growth, migration, and invasion of liver cancer cells, which might be through regulating miR-15a-3p/STAT3 axis. +lncRNA target 31099050 hsa-mir-337 Carcinoma, Hepatocellular 3p/SIX1 axis, suggesting a promising therapeutic target in HCC. +lncRNA target 31099048 hsa-mir-146b Nasopharyngeal Carcinoma To further investigate the molecular mechanism of SOX2-OT, miR-146b-5p was found to directly bind to SOX2-OT, which mediated the role of SOX2-OT in NPC tumorigenesis. At last, we discovered that SOX2-OT regulated NPC progression by targeting miR-146b-5p/HNRNPA2B1 pathway, which may provide more innovative targets for the treatment of patients with NPC. +lncRNA target 31099044 hsa-mir-630 Uterine Cervical Neoplasms Recently, studies have shown that lncRNA NOC2L-4.1 was abnormally expressed in patients with cervical cancer and can target miR-630. +lncRNA target 31099043 hsa-mir-9 Liver Injury These results demonstrated that MCPIP1 could alleviate inflammation responses and sepsis associated liver injury by promoting the expression of SIRT1, and miR-9 was involved in the MCPIP1-mediated regulation of SIRT1. +genetics_knock down_promote 31097683 hsa-mir-23b Osteosarcoma Functional studies suggested that knockdown of miR-23b-3p could inhibit OS cell proliferation in vitro or in vivo. +other 31097355 hsa-mir-1249 Breast Neoplasms Taken all together, our findings proved that MIF-AS1 acted as a ceRNA by modulating miR3p/HOXB8 axis in breast cancer. +other 31097000 hsa-mir-29b Leukemia, Myeloid, Acute However, it is still less understood that the miR-29b/Sp1/FUT4 crosstalk involved in the fucosylation-mediated LSCs malignancy in AML. +other 31097000 hsa-mir-29b Leukemia However, it is still less understood that the miR-29b/Sp1/FUT4 crosstalk involved in the fucosylation-mediated LSCs malignancy in AML. +circulation_biomarker_diagnosis_ns 31096984 hsa-mir-409 Biliary Tract Neoplasms CONCLUSIONS: These results suggested three candidate serum miRNAs (mir +circulation_biomarker_diagnosis_ns 31096984 hsa-mir-744 Biliary Tract Neoplasms CONCLUSIONS: These results suggested three candidate serum miRNAs (mir +lncRNA target 31096819 hsa-mir-138 Intracranial Aneurysm The real-time PCR result indicated that circRNA_0020397 was down-regulated, but miR-138 was up-regulated in artery wall tissues and cells of IA. In conclusion, our findings demonstrated that decreased expression of circRNA_0020397 in IA may contribute to the decreased VSMC proliferation via increasing miR-138 expression and subsequently decreasing KDR expression. +other 31096184 hsa-mir-299 Adrenocortical Adenoma Additionally, we found significant correlations among miR299, CACNB2, and CYP11B2 levels in APA tissues. +lncRNA target 31096145 hsa-mir-4319 Carcinoma, Non-Small-Cell Lung In this study, we proved that miR-4319 acted as a tumor suppressor in NSCLC progression via restraining cell proliferation and migration as well as boosting apoptosis. +circulation_biomarker_diagnosis_ns 31095784 hsa-mir-29a Colitis This was accomplished through assessing the expression levels of five miRNAs (miR-141, miR-15b, miR3p, miR-21, and miR-29a) in serum and their corresponding tissue samples through the different cycles of colorectal carcinogenesis cascade using the azoxymethane/dextran sulfate sodium murine model. +circulation_biomarker_diagnosis_ns 31095784 hsa-mir-29a Colorectal Neoplasms This was accomplished through assessing the expression levels of five miRNAs (miR-141, miR-15b, miR3p, miR-21, and miR-29a) in serum and their corresponding tissue samples through the different cycles of colorectal carcinogenesis cascade using the azoxymethane/dextran sulfate sodium murine model. +circulation_biomarker_diagnosis_ns 31095784 hsa-mir-15b Colorectal Neoplasms This was accomplished through assessing the expression levels of five miRNAs (miR-141, miR-15b, miR3p, miR-21, and miR-29a) in serum and their corresponding tissue samples through the different cycles of colorectal carcinogenesis cascade using the azoxymethane/dextran sulfate sodium murine model. +circulation_biomarker_diagnosis_ns 31095784 hsa-mir-17 Colorectal Neoplasms This was accomplished through assessing the expression levels of five miRNAs (miR-141, miR-15b, miR3p, miR-21, and miR-29a) in serum and their corresponding tissue samples through the different cycles of colorectal carcinogenesis cascade using the azoxymethane/dextran sulfate sodium murine model. +circulation_biomarker_diagnosis_ns 31095784 hsa-mir-15b Colitis This was accomplished through assessing the expression levels of five miRNAs (miR-141, miR-15b, miR3p, miR-21, and miR-29a) in serum and their corresponding tissue samples through the different cycles of colorectal carcinogenesis cascade using the azoxymethane/dextran sulfate sodium murine model. +circulation_biomarker_diagnosis_ns 31095784 hsa-mir-21 Colorectal Neoplasms This was accomplished through assessing the expression levels of five miRNAs (miR-141, miR-15b, miR3p, miR-21, and miR-29a) in serum and their corresponding tissue samples through the different cycles of colorectal carcinogenesis cascade using the azoxymethane/dextran sulfate sodium murine model. +circulation_biomarker_diagnosis_ns 31095784 hsa-mir-21 Colitis This was accomplished through assessing the expression levels of five miRNAs (miR-141, miR-15b, miR3p, miR-21, and miR-29a) in serum and their corresponding tissue samples through the different cycles of colorectal carcinogenesis cascade using the azoxymethane/dextran sulfate sodium murine model. +circulation_biomarker_diagnosis_ns 31095784 hsa-mir-141 Colorectal Neoplasms This was accomplished through assessing the expression levels of five miRNAs (miR-141, miR-15b, miR3p, miR-21, and miR-29a) in serum and their corresponding tissue samples through the different cycles of colorectal carcinogenesis cascade using the azoxymethane/dextran sulfate sodium murine model. +circulation_biomarker_diagnosis_ns 31095784 hsa-mir-17 Colitis This was accomplished through assessing the expression levels of five miRNAs (miR-141, miR-15b, miR3p, miR-21, and miR-29a) in serum and their corresponding tissue samples through the different cycles of colorectal carcinogenesis cascade using the azoxymethane/dextran sulfate sodium murine model. +circulation_biomarker_diagnosis_ns 31095784 hsa-mir-141 Colitis This was accomplished through assessing the expression levels of five miRNAs (miR-141, miR-15b, miR3p, miR-21, and miR-29a) in serum and their corresponding tissue samples through the different cycles of colorectal carcinogenesis cascade using the azoxymethane/dextran sulfate sodium murine model. +other 31095782 hsa-mir-10b hereditary diffuse gastric cancer Here, we aimed to investigate the expression relevance of three prognostic miRNAs (miR-21, miR-10b, and miR-146a) in CSCs of AGS and MKN-45 gastric cancer cell lines. +other 31095782 hsa-mir-10b Aicardi-Goutieres syndrome 5 Here, we aimed to investigate the expression relevance of three prognostic miRNAs (miR-21, miR-10b, and miR-146a) in CSCs of AGS and MKN-45 gastric cancer cell lines. AGS-derived gastro-spheres showed upregulation of miR-21 (4.7-folds; P<0.01), miR-10b (15.2-folds; P<0.001) and miR-146a (39.3-folds; P<0.05). +other 31095782 hsa-mir-21 Aicardi-Goutieres syndrome 5 Here, we aimed to investigate the expression relevance of three prognostic miRNAs (miR-21, miR-10b, and miR-146a) in CSCs of AGS and MKN-45 gastric cancer cell lines. AGS-derived gastro-spheres showed upregulation of miR-21 (4.7-folds; P<0.01), miR-10b (15.2-folds; P<0.001) and miR-146a (39.3-folds; P<0.05). +other 31095782 hsa-mir-21 hereditary diffuse gastric cancer Here, we aimed to investigate the expression relevance of three prognostic miRNAs (miR-21, miR-10b, and miR-146a) in CSCs of AGS and MKN-45 gastric cancer cell lines. +other 31095782 hsa-mir-146a hereditary diffuse gastric cancer Here, we aimed to investigate the expression relevance of three prognostic miRNAs (miR-21, miR-10b, and miR-146a) in CSCs of AGS and MKN-45 gastric cancer cell lines. +other 31095782 hsa-mir-146a Aicardi-Goutieres syndrome 5 Here, we aimed to investigate the expression relevance of three prognostic miRNAs (miR-21, miR-10b, and miR-146a) in CSCs of AGS and MKN-45 gastric cancer cell lines. AGS-derived gastro-spheres showed upregulation of miR-21 (4.7-folds; P<0.01), miR-10b (15.2-folds; P<0.001) and miR-146a (39.3-folds; P<0.05). +circulation_biomarker_diagnosis_ns 31095096 hsa-mir-223 Complex Regional Pain Syndromes Furthermore, the immunobarrier-protective hsa-miR5p was increased in plasma exosomes in FCs with normal healing, but not in CRPS and healthy controls. +genetics_overexpression_promote 31094297 hsa-mir-655 Carcinoma, Non-Small-Cell Lung 3p overexpression significantly inhibited migration and invasion of A549 and PC14/b cells, and pituitary tumor-transforming 1 (PTTG1) expression was up-regulated in the NSCLC cells. +other 31094072 hsa-mir-125b Diabetes Mellitus miR-125b-5p and miR-146a-5p were down-regulated by hyperglycaemia and/or hypoxia. +other 31094072 hsa-mir-146a Retinal Diseases miR-125b-5p and miR-146a-5p were down-regulated by hyperglycaemia and/or hypoxia. +other 31094072 hsa-mir-125b Retinal Diseases miR-125b-5p and miR-146a-5p were down-regulated by hyperglycaemia and/or hypoxia. +other 31094072 hsa-mir-146a Diabetes Mellitus miR-125b-5p and miR-146a-5p were down-regulated by hyperglycaemia and/or hypoxia. +genetics_knock down_promote 31094023 hsa-mir-574 Colorectal Neoplasms Then, the CRC cells lines (LoVo and RKO) were transfected with MFI2-AS1 siRNA, miR +other 31093978 hsa-mir-605 Glioma 3p/VASP axis in glioma progression. +lncRNA target 31093905 hsa-mir-17 Brain Ischemia 5p) could suppress the expression of SARA in esophageal squamous cell carcinoma. +lncRNA target 31093891 hsa-mir-34a Uterine Cervical Neoplasms CONCLUSIONS: These results indicate that ultrasound-mediated PTX-miR-34a-MBs synergistically inhibit the growth of cervical cancer via the upregulation of miR-34a and downregulation of Bcl-2 and CDK6. +other 31092995 hsa-mir-183 Prostatic Neoplasms 5p may be useful as a new tissue specific diagnostic biomarker in prostate cancer. +lncRNA target 31092700 hsa-mir-101 Uterine Cervical Neoplasms 3p to regulate the expression of the target gene ZEB1Conclusions: Our findings indicate that the SPYR4-IT1/miR +lncRNA target 31092334 hsa-mir-25 Carcinoma, Hepatocellular In summary, HDAC may up-regulate C/EBPalpha expression through miR +lncRNA target 31092334 hsa-mir-124 Carcinoma, Hepatocellular In summary, HDAC may up-regulate C/EBPalpha expression through miR +genetics_knock down_promote 31092328 hsa-mir-93 Osteosarcoma 3p effectively reversed the effects of AWPPH knockdown on OS cells. +circulation_biomarker_diagnosis_up 31092279 hsa-mir-92a Alzheimer Disease CONCLUSION Our study shows that plasma miR-92a-3p, miR-181c-5p and miR +circulation_biomarker_diagnosis_up 31092279 hsa-mir-181c Alzheimer Disease CONCLUSION Our study shows that plasma miR-92a-3p, miR-181c-5p and miR +circulation_biomarker_diagnosis_up 31092279 hsa-mir-210 Alzheimer Disease CONCLUSION Our study shows that plasma miR-92a-3p, miR-181c-5p and miR +circulation_biomarker_diagnosis_ns 31092195 hsa-mir-146a Myocardial Infarction, Acute RESULTS: The expression levels of plasma miR-26a-1, miR-146a and miR-199a-1 were significantly increased in AMI patients. +circulation_biomarker_diagnosis_ns 31092195 hsa-mir-26a-1 Myocardial Infarction, Acute RESULTS: The expression levels of plasma miR-26a-1, miR-146a and miR-199a-1 were significantly increased in AMI patients. +circulation_biomarker_diagnosis_ns 31092195 hsa-mir-199a-1 Myocardial Infarction, Acute RESULTS: The expression levels of plasma miR-26a-1, miR-146a and miR-199a-1 were significantly increased in AMI patients. +transcription factor target 31091971 hsa-mir-520 Lung Neoplasms Our findings indicate that OMT inhibited cancer progression and metastasis by upregulation of miR-520 and downregulation of VEGF, which provide new support for OMT may be as a novel anticancer drug for the treatment of lung cancer in the future. +genetics_overexpression_promote 31091851 hsa-mir-135a Epilepsy, Temporal Lobe Overexpression of miR-135a-5p induced cell apoptosis through inhibition of caspase activity and apoptosis inhibitor 1 expression and suppressed cell survival in children with temporal lobe epilepsy. +genetics_overexpression_suppress 31091849 hsa-mir-362 Spinal Cord Injuries 3p overexpression in spinal cord injury rats, which expressed the low microRNA +circulation_biomarker_diagnosis_up 31091580 hsa-mir-126 Coronary Stenosis Conclusion: The expression level of miR-126 in plasma is significantly correlated with CSF, and miR-126 can be used as a predictor of coronary slow flow phenomenon. +genetics_knock down_suppress 31091229 hsa-mir-26a Hemorrhagic Disorders We show that loss of miR26a leads to hemorrhage (a loss of vascular stability) in vivo, suggesting altered vascular differentiation. Normalization of Smad1 levels through double knockdown of miR26a and smad1 rescues hemorrhage, suggesting a direct relationship between miR26a, smad1 and vascular stability. +lncRNA target 31091144 hsa-mir-144 Acquired Immunodeficiency Syndrome This study provides new experimental evidence that HIV-induced inhibition of Nrf2 and consequent AEC barrier dysfunction are mediated via miR-144, and that these pathophysiological effects can be mitigated in vivo by either directly antagonizing miR-144 or activating Nrf2. +circulation_biomarker_diagnosis_ns 31091026 hsa-mir-203 Colorectal Neoplasms CONCLUSIONS Assessment of serum miR-203 expression could be used for risk assessment of myopenia, and miR-203 might be a novel therapeutic target for inhibition of myopenia in CRC. +circulation_biomarker_diagnosis_ns 31091026 hsa-mir-203 Muscular Diseases CONCLUSIONS Assessment of serum miR-203 expression could be used for risk assessment of myopenia, and miR-203 might be a novel therapeutic target for inhibition of myopenia in CRC. +other 31090954 hsa-mir-214 Diabetes Mellitus The miR-214 level, receptor-interacting serine-threonine protein (RIP) 1, RIP3, and phospho-mixed lineage kinase domain-like (p-MLKL) protein expression were elevated in the inflamed gingival tissues of diabetes-associated periodontitis patients, with activating transcription factor 4 (ATF4) expression showing the opposite effect. +lncRNA target 31090110 hsa-mir-27a Hypoxia LncRNA NEAT1 promotes hypoxia-induced renal tubular epithelial apoptosis through downregulating miR-27a-3p. +other 31090110 hsa-mir-27a Acute Kidney Injury The expressions of NEAT1 and miR-27a-3p in ischemia/reperfusion-induced AKI patients were examined by quantitative reverse transcription polymerase chain reaction. +lncRNA target 31090110 hsa-mir-27a Ischemia The expressions of NEAT1 and miR-27a-3p in ischemia/reperfusion-induced AKI patients were examined by quantitative reverse transcription polymerase chain reaction. In summary, an ischemia-induced injury may be enhanced by a high level of NEAT1 through targeting miR-27a-3p. +other 31090078 hsa-mir-122 Osteoarthritis For osteoarthritis patients taking acetaminophen with or without Ojeok-san, monitoring potential liver toxicity using miR-122 as a biomarker may be useful. +other 31089945 hsa-mir-126 Hyperglycemia RESULTS: High glucose led to premature senescence of HGMCs, as evident from the increase in the percentage of SA-beta-gal-positive cells, decrease in telomere length, cell cycle arrest at G1 phase,decrease in the expression of miR-126 and p-Akt and increase in the expression of p53, p21 and Rb proteins in the HG group. +lncRNA target 31089916 hsa-mir-20 Reperfusion Injury Luteolin confers renoprotection against ischemia-reperfusion injury via involving Nrf2 pathway and regulating miR320. This work aims to evaluate the renoprotective effect of luteolin on expression of Nrf2 and miR320 in ischemia-reperfusion (I/R) injury in rats. +circulation_biomarker_diagnosis_up 31089750 hsa-mir-1246 Colorectal Neoplasms CONCLUSIONS: Our study demonstrates that a panel of serum exosomal miRNAs containing miR +circulation_biomarker_diagnosis_up 31089750 hsa-mir-96 Colorectal Neoplasms CONCLUSIONS: Our study demonstrates that a panel of serum exosomal miRNAs containing miR +circulation_biomarker_diagnosis_up 31089750 hsa-mir-21 Colorectal Neoplasms CONCLUSIONS: Our study demonstrates that a panel of serum exosomal miRNAs containing miR +circulation_biomarker_diagnosis_up 31089750 hsa-mir-1229 Colorectal Neoplasms CONCLUSIONS: Our study demonstrates that a panel of serum exosomal miRNAs containing miR +circulation_biomarker_prognosis_ns 31089400 hsa-mir-200c Stomach Neoplasms CONCLUSIONS: Both serum and tissue miR-200c have moderate diagnostic accuracy in gastric cancer. +other 31089267 hsa-mir-196a Nevoid Basal Cell Carcinoma Syndrome 1@En Moreover, hsa-miR-196a-5p is complementary to sites in the 3' UTR of MAP3K1, which exhibits upregulated expression at mRNA and protein levels in GS fibroblasts. +lncRNA target 31089163 hsa-mir-126 Vascular Diseases These data indicate that HIF-1alpha is a target of miRNA-126 in protective and reparative functions, and suggest that their therapeutic modulation could benefit age-related vascular disease. +transcription factor target 31088519 hsa-mir-29c Pneumonia, Mycoplasma miR-29c and B7-H3 may be the new target for the prevention and treatment of MPP, and may be the novel and potential biomarkers for the assessment of prognosis. +other 31088501 hsa-mir-24 Multiple System Atrophy 3p may reflect the pathophysiology or symptoms of PD and MSA. +other 31088501 hsa-mir-19b Parkinson Disease 3p may reflect the pathophysiology or symptoms of PD and MSA. +other 31088501 hsa-mir-24 Parkinson Disease 3p may reflect the pathophysiology or symptoms of PD and MSA. +other 31088501 hsa-mir-19b Multiple System Atrophy 3p may reflect the pathophysiology or symptoms of PD and MSA. +other 31088429 hsa-mir-223 Sepsis CONCLUSIONS: MiR3p could be utilized to predict sepsis secondary to pneumonia. +other 31088429 hsa-mir-223 Pneumonia CONCLUSIONS: MiR3p could be utilized to predict sepsis secondary to pneumonia. +other 31087825 hsa-mir-5695 Neurotic Disorders The best model included baseline depression severity and expression of STMN1 and miR-5695 and predicted TWSI with area under the curve = 0.94 (P < .001). +other 31087825 hsa-mir-3688 Wounds and Injuries Two mRNAs (stathmin 1 [STMN1] and protein phosphatase 1 regulatory subunit 9B [PPP1R9B]) and 2 miRNAs (miR-3688 and miR-5695) were identified that were significantly predictive of TWSI when mRNA and miRNA were assessed separately (P = .002, .044, .004, and .005, respectively). +other 31087825 hsa-mir-5695 Wounds and Injuries Two mRNAs (stathmin 1 [STMN1] and protein phosphatase 1 regulatory subunit 9B [PPP1R9B]) and 2 miRNAs (miR-3688 and miR-5695) were identified that were significantly predictive of TWSI when mRNA and miRNA were assessed separately (P = .002, .044, .004, and .005, respectively). The best model included baseline depression severity and expression of STMN1 and miR-5695 and predicted TWSI with area under the curve = 0.94 (P < .001). +lncRNA target 31087707 hsa-mir-141 Breast Neoplasms 3p could restore the sensitivity to trastuzumab in breast cancer cells by repressing CDK8, which might regulate the phosphorylation levels of SMAD2/SMAD3 via TGF-beta. +other 31087541 hsa-mir-181 Cardiomegaly Cluster B contained c-miRNA identified as regulators of cardiac hypertrophy (c-miRNA-30, -15), fibrosis (c-miRNA-22, -18), mitochondrial function (miRNA-181), and aerobic capacity (c-miRNA-20a). +other 31087541 hsa-mir-20a Heart Diseases Cluster B contained c-miRNA identified as regulators of cardiac hypertrophy (c-miRNA-30, -15), fibrosis (c-miRNA-22, -18), mitochondrial function (miRNA-181), and aerobic capacity (c-miRNA-20a). +other 31087541 hsa-mir-22 Cardiomegaly Cluster B contained c-miRNA identified as regulators of cardiac hypertrophy (c-miRNA-30, -15), fibrosis (c-miRNA-22, -18), mitochondrial function (miRNA-181), and aerobic capacity (c-miRNA-20a). +other 31087541 hsa-mir-181 Fibrosis Cluster B contained c-miRNA identified as regulators of cardiac hypertrophy (c-miRNA-30, -15), fibrosis (c-miRNA-22, -18), mitochondrial function (miRNA-181), and aerobic capacity (c-miRNA-20a). +other 31087541 hsa-mir-133 Muscular Atrophy Cluster A included c-miRNA that have been identified as regulators of cardiac function and hypertrophy (c-miRNA-133), atrial fibrillation and mitochondrial function (c-miRNA-1), skeletal muscle atrophy (c-miRNA-1), and vascular control (c-miRNA-155). +other 31087541 hsa-mir-155 Heart Diseases Cluster A included c-miRNA that have been identified as regulators of cardiac function and hypertrophy (c-miRNA-133), atrial fibrillation and mitochondrial function (c-miRNA-1), skeletal muscle atrophy (c-miRNA-1), and vascular control (c-miRNA-155). +other 31087541 hsa-mir-133 Hypertrophy Cluster A included c-miRNA that have been identified as regulators of cardiac function and hypertrophy (c-miRNA-133), atrial fibrillation and mitochondrial function (c-miRNA-1), skeletal muscle atrophy (c-miRNA-1), and vascular control (c-miRNA-155). +other 31087541 hsa-mir-181 Hypertrophy Cluster B contained c-miRNA identified as regulators of cardiac hypertrophy (c-miRNA-30, -15), fibrosis (c-miRNA-22, -18), mitochondrial function (miRNA-181), and aerobic capacity (c-miRNA-20a). +other 31087541 hsa-mir-20a Hypertrophy Cluster B contained c-miRNA identified as regulators of cardiac hypertrophy (c-miRNA-30, -15), fibrosis (c-miRNA-22, -18), mitochondrial function (miRNA-181), and aerobic capacity (c-miRNA-20a). +other 31087541 hsa-mir-181 Heart Diseases Cluster B contained c-miRNA identified as regulators of cardiac hypertrophy (c-miRNA-30, -15), fibrosis (c-miRNA-22, -18), mitochondrial function (miRNA-181), and aerobic capacity (c-miRNA-20a). +other 31087541 hsa-mir-22 Heart Diseases Cluster B contained c-miRNA identified as regulators of cardiac hypertrophy (c-miRNA-30, -15), fibrosis (c-miRNA-22, -18), mitochondrial function (miRNA-181), and aerobic capacity (c-miRNA-20a). +other 31087541 hsa-mir-155 Muscular Atrophy Cluster A included c-miRNA that have been identified as regulators of cardiac function and hypertrophy (c-miRNA-133), atrial fibrillation and mitochondrial function (c-miRNA-1), skeletal muscle atrophy (c-miRNA-1), and vascular control (c-miRNA-155). +other 31087541 hsa-mir-155 Hypertrophy Cluster A included c-miRNA that have been identified as regulators of cardiac function and hypertrophy (c-miRNA-133), atrial fibrillation and mitochondrial function (c-miRNA-1), skeletal muscle atrophy (c-miRNA-1), and vascular control (c-miRNA-155). +other 31087541 hsa-mir-133 Heart Diseases Cluster A included c-miRNA that have been identified as regulators of cardiac function and hypertrophy (c-miRNA-133), atrial fibrillation and mitochondrial function (c-miRNA-1), skeletal muscle atrophy (c-miRNA-1), and vascular control (c-miRNA-155). +other 31087541 hsa-mir-133 Atrial Fibrillation Cluster A included c-miRNA that have been identified as regulators of cardiac function and hypertrophy (c-miRNA-133), atrial fibrillation and mitochondrial function (c-miRNA-1), skeletal muscle atrophy (c-miRNA-1), and vascular control (c-miRNA-155). +other 31087541 hsa-mir-20a Fibrosis Cluster B contained c-miRNA identified as regulators of cardiac hypertrophy (c-miRNA-30, -15), fibrosis (c-miRNA-22, -18), mitochondrial function (miRNA-181), and aerobic capacity (c-miRNA-20a). +other 31087541 hsa-mir-20a Cardiomegaly Cluster B contained c-miRNA identified as regulators of cardiac hypertrophy (c-miRNA-30, -15), fibrosis (c-miRNA-22, -18), mitochondrial function (miRNA-181), and aerobic capacity (c-miRNA-20a). +other 31087541 hsa-mir-155 Atrial Fibrillation Cluster A included c-miRNA that have been identified as regulators of cardiac function and hypertrophy (c-miRNA-133), atrial fibrillation and mitochondrial function (c-miRNA-1), skeletal muscle atrophy (c-miRNA-1), and vascular control (c-miRNA-155). +other 31087541 hsa-mir-22 Hypertrophy Cluster B contained c-miRNA identified as regulators of cardiac hypertrophy (c-miRNA-30, -15), fibrosis (c-miRNA-22, -18), mitochondrial function (miRNA-181), and aerobic capacity (c-miRNA-20a). +other 31087541 hsa-mir-22 Fibrosis Cluster B contained c-miRNA identified as regulators of cardiac hypertrophy (c-miRNA-30, -15), fibrosis (c-miRNA-22, -18), mitochondrial function (miRNA-181), and aerobic capacity (c-miRNA-20a). +lncRNA target 31087138 hsa-mir-552 Turcot syndrome Effects of miR-552 dysregulation on 5-FU resistance in CRC cells were determined by measuring cell viability, apoptosis and in vivo oncogenic capacity. +other 31087038 hsa-mir-144 Glioblastoma Taken together, our findings provide evidence that the miR-144 plus DCA combined therapy holds promise to overcome GB-acquired chemoresistance, therefore deserving to be explored toward its potential application as a complementary therapeutic approach to the current treatment options for this type of brain tumor. +genetics_overexpression_promote 31086603 hsa-mir-153 Breast Neoplasms Overexpression of miR-153 reduced proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) in breast cancer SK-BR-3 and BT-549 cells. +circulation_biomarker_diagnosis_ns 31086599 hsa-mir-146a Hepatitis B The aim of the present study was to measure the expression of microRNA (miR)-146a in liver tissues, peripheral blood mononuclear cells (PMBC) and serum from patients with Hepatitis B and either liver fibrosis or cirrhosis, as well as to determine the regulatory mechanism of miR-146a. miR-146a directly targets IL-6, which may regulate the occurrence and immune responses of Hepatitis B. +transcription factor target 31086597 hsa-mir-214 Myocardial Infarction, Acute miRNA-214 was highly expressed in the sera of elderly patients with AMI, which may inhibit myocardial cell apoptosis by inhibiting the expression of miR-214 target genes including PUMA, PTEN, Bax and caspase 7. +circulation_biomarker_diagnosis_ns 31086594 hsa-mir-291 Liver Cirrhosis In summary, reduced peripheral blood miR +circulation_biomarker_diagnosis_ns 31086590 hsa-mir-99a Abortion, Spontaneous Expression of TGF-beta1 and miR-99a in patients with early spontaneous abortion and correlation with hormone levels during pregnancy were investigated. miR-99a was highly expressed in the serum of patients with early spontaneous abortion, but TGF-beta1 expression was low. +genetics_overexpression_promote 31086578 hsa-mir-181a Retinal Detachment miR-181a overexpression vector (miR-181a-mimic group) was constructed and transfected into lens epithelial cells isolated from patients with rhegmatogenous retinal detachment combined with age-related cataract. +lncRNA target 31086572 hsa-mir-1271 Colorectal Neoplasms The results of the present study indicate that miR-1271 may be a potential target for anti-CRC therapy, particularly in the sensitivity of chemotherapeutic drugs. +other 31086530 hsa-mir-203 Stomach Neoplasms CONCLUSION: In this study, a close correlation of D-dimer, miR203 and CD147 was found, and these three biomarkers should be screened in gastric cancer patients. +circulation_biomarker_diagnosis_ns 31086410 hsa-mir-26a Osteoporotic Fractures CONCLUSIONS Circulating miR-26a-5p, -34a-5p and +circulation_biomarker_diagnosis_ns 31086410 hsa-mir-26a Aortic Valve Disease CONCLUSIONS Circulating miR-26a-5p, -34a-5p and +other 31085811 hsa-mir-93 Heart Failure At the meantime, the expression of four heart failure-related miRNAs was altered when lncRNA GAS5 was silenced (miR-21 and miR5p were up-regulated; miR-30b and miR-93 were down-regulated). +other 31085811 hsa-mir-142 Heart Failure At the meantime, the expression of four heart failure-related miRNAs was altered when lncRNA GAS5 was silenced (miR-21 and miR5p were up-regulated; miR-30b and miR-93 were down-regulated). +other 31085811 hsa-mir-21 Heart Failure At the meantime, the expression of four heart failure-related miRNAs was altered when lncRNA GAS5 was silenced (miR-21 and miR5p were up-regulated; miR-30b and miR-93 were down-regulated). +lncRNA target 31085805 hsa-mir-495 Cicatrix, Hypertrophic Our findings show that miR-495 inhibits FAK and its downstream mediators in vitro and vivo, and suggest that miR-495 may be a useful therapeutic target for the treatment of hypertrophic scar. +other 31085440 hsa-mir-155 Multiple Organ Failure The results clearly show that the upregulation of miR-155 expression can increase the risk of arsenic induced skin damage (OR=10.55; 95% CI: 6.02, 18.47); further, there is a link between the expression of miR-21 (OR=11.84; 95% CI: 5.34, 26.28) and miR-145 (OR=2.39; 95% CI: 1.61, 3.55) and liver damage, and miR-191 and kidney damage (OR=3.65; 95% CI: 1.49, 8.93). It was found that the miR-155 has a certain diagnostic value in arsenic-induced skin damage (AUC=0.83), miR-21 and miR-145 have diagnostic value for liver damage (AUC=0.80, 0.81) and miR-191 has diagnostic value for kidney damage (AUC=0.83). +other 31085440 hsa-mir-145 Multiple Organ Failure The results clearly show that the upregulation of miR-155 expression can increase the risk of arsenic induced skin damage (OR=10.55; 95% CI: 6.02, 18.47); further, there is a link between the expression of miR-21 (OR=11.84; 95% CI: 5.34, 26.28) and miR-145 (OR=2.39; 95% CI: 1.61, 3.55) and liver damage, and miR-191 and kidney damage (OR=3.65; 95% CI: 1.49, 8.93). It was found that the miR-155 has a certain diagnostic value in arsenic-induced skin damage (AUC=0.83), miR-21 and miR-145 have diagnostic value for liver damage (AUC=0.80, 0.81) and miR-191 has diagnostic value for kidney damage (AUC=0.83). +other 31085440 hsa-mir-191 Multiple Organ Failure The results clearly show that the upregulation of miR-155 expression can increase the risk of arsenic induced skin damage (OR=10.55; 95% CI: 6.02, 18.47); further, there is a link between the expression of miR-21 (OR=11.84; 95% CI: 5.34, 26.28) and miR-145 (OR=2.39; 95% CI: 1.61, 3.55) and liver damage, and miR-191 and kidney damage (OR=3.65; 95% CI: 1.49, 8.93). It was found that the miR-155 has a certain diagnostic value in arsenic-induced skin damage (AUC=0.83), miR-21 and miR-145 have diagnostic value for liver damage (AUC=0.80, 0.81) and miR-191 has diagnostic value for kidney damage (AUC=0.83). +other 31085440 hsa-mir-21 Multiple Organ Failure The results clearly show that the upregulation of miR-155 expression can increase the risk of arsenic induced skin damage (OR=10.55; 95% CI: 6.02, 18.47); further, there is a link between the expression of miR-21 (OR=11.84; 95% CI: 5.34, 26.28) and miR-145 (OR=2.39; 95% CI: 1.61, 3.55) and liver damage, and miR-191 and kidney damage (OR=3.65; 95% CI: 1.49, 8.93). It was found that the miR-155 has a certain diagnostic value in arsenic-induced skin damage (AUC=0.83), miR-21 and miR-145 have diagnostic value for liver damage (AUC=0.80, 0.81) and miR-191 has diagnostic value for kidney damage (AUC=0.83). +other 31085276 hsa-mir-466 Prostatic Neoplasms miR-466 was downregulated in tumor tissues compared with adjacent healthy tissues of prostate carcinoma patients. Therefore, TUC338 may serve as an oncogenic lncRNA in prostate carcinoma by downregulating miR-466. +other 31085188 hsa-mir-124 Endometriosis From these results, we can infer that in endometriosis both miR3p and ITGB3 operate as downstream effector proteins in the H19-signaling pathway. +lncRNA target 31085161 hsa-mir-193a Kidney Diseases Taken together, these results provide the first evidence that MgIG restrains fructose-induced podocyte apoptosis at least partly through inhibiting miR-193a to upregulate WT1, supporting the application of MgIG with a novel mechanism-of-action against podocyte apoptosis associated with fructose-induced kidney dysfunction. +other 31085161 hsa-mir-193a Wilms Tumor Of note, high-expression of miR-193a, downregulation of Wilms' tumor protein (WT1) and RelA, as well as upregulation of C-Maf inducing protein (C-mip) were observed in these animal and cell models. +lncRNA target 31085161 hsa-mir-193a hereditary fructose intolerance syndrome Taken together, these results provide the first evidence that MgIG restrains fructose-induced podocyte apoptosis at least partly through inhibiting miR-193a to upregulate WT1, supporting the application of MgIG with a novel mechanism-of-action against podocyte apoptosis associated with fructose-induced kidney dysfunction. +other 31085080 hsa-mir-19a Vascular Diseases However, if entering all five miRNAs (along with other covariates) into a single regression model, only low miR-19a remained a significant mortality predictor; and only in patients with coronary artery disease [3.00 (95% CI: 1.77-5.08)], but not in post-stroke patients [1.63 (95% CI: 0.94-2.86)]. CONCLUSIONS In stable chronic coronary artery disease patients, low miR-19a expression was associated with a substantial increase in mortality risk independently of other conventional cardiovascular risk factors. +other 31085080 hsa-mir-1 Vascular Diseases However, if entering all five miRNAs (along with other covariates) into a single regression model, only low miR-19a remained a significant mortality predictor; and only in patients with coronary artery disease [3.00 (95% CI: 1.77-5.08)], but not in post-stroke patients [1.63 (95% CI: 0.94-2.86)]. CONCLUSIONS In stable chronic coronary artery disease patients, low miR-19a expression was associated with a substantial increase in mortality risk independently of other conventional cardiovascular risk factors. +other 31085080 hsa-mir-19 Vascular Diseases However, if entering all five miRNAs (along with other covariates) into a single regression model, only low miR-19a remained a significant mortality predictor; and only in patients with coronary artery disease [3.00 (95% CI: 1.77-5.08)], but not in post-stroke patients [1.63 (95% CI: 0.94-2.86)]. CONCLUSIONS In stable chronic coronary artery disease patients, low miR-19a expression was associated with a substantial increase in mortality risk independently of other conventional cardiovascular risk factors. +circulation_biomarker_diagnosis_ns 31085080 hsa-mir-126 Vascular Diseases METHODS The plasma concentrations of five selected microRNAs (miR-1, miR-19, miR-126, miR-133 and miR-223) were quantified in 826 patients (mean age 65.2years) with stable vascular disease (6-36months after acute coronary syndrome, coronary revascularization or first-ever ischemic stroke). +circulation_biomarker_diagnosis_ns 31085080 hsa-mir-223 Vascular Diseases METHODS The plasma concentrations of five selected microRNAs (miR-1, miR-19, miR-126, miR-133 and miR-223) were quantified in 826 patients (mean age 65.2years) with stable vascular disease (6-36months after acute coronary syndrome, coronary revascularization or first-ever ischemic stroke). +circulation_biomarker_diagnosis_ns 31085080 hsa-mir-133 Vascular Diseases METHODS The plasma concentrations of five selected microRNAs (miR-1, miR-19, miR-126, miR-133 and miR-223) were quantified in 826 patients (mean age 65.2years) with stable vascular disease (6-36months after acute coronary syndrome, coronary revascularization or first-ever ischemic stroke). +circulation_biomarker_diagnosis_down 31085006 hsa-mir-671 Osteoarthritis RESULTS: We found that the level of miR-671 was downregulated in OA tissues, plasma and IL-1beta treated CHON-001 cells, compared with control. +circulation_biomarker_diagnosis_ns 31084998 hsa-mir-765 Coronary Occlusion 5p, and miR-206 were independently associated with CHD while circulating levels of miR-765 (p=0.035), miR +circulation_biomarker_diagnosis_ns 31084998 hsa-mir-1 Coronary Occlusion 5p, and miR-206 were independently associated with CHD while circulating levels of miR-765 (p=0.035), miR +other 31084998 hsa-let-7c Coronary Occlusion 5p, and miR-206 were upregulated in CHD patients (n=66) versus healthy subjects HS (n=29); moreover, let-7c-5p, miR-765, miR- 483-5p showed higher expression in obstructive CHD (n=36) compared to no obstructive CHD patients (n=66). +circulation_biomarker_diagnosis_ns 31084998 hsa-mir-433 Coronary Occlusion 5p, and miR-206 were independently associated with CHD while circulating levels of miR-765 (p=0.035), miR +other 31084998 hsa-mir-483 Coronary Occlusion 5p, and miR-206 were upregulated in CHD patients (n=66) versus healthy subjects HS (n=29); moreover, let-7c-5p, miR-765, miR- 483-5p showed higher expression in obstructive CHD (n=36) compared to no obstructive CHD patients (n=66). +circulation_biomarker_diagnosis_ns 31084998 hsa-mir-206 Coronary Occlusion 5p, and miR-206 were independently associated with CHD while circulating levels of miR-765 (p=0.035), miR +circulation_biomarker_diagnosis_ns 31084998 hsa-mir-93 Coronary Occlusion 5p, and miR-206 were independently associated with CHD while circulating levels of miR-765 (p=0.035), miR +other 31084743 hsa-mir-21 Breast Neoplasms The miR-21 expression in tissue was also evaluated depend on histopathological features, molecular subtypes and prognosis of breast cancer. +other 31084400 hsa-mir-143 Osteosarcoma OBJECTIVE: To investigate the expression of miR-21, miR-221, miR-143, and miR-106a in patients' osteosarcoma samples, and to explore the correlation between these microRNAs (miRNAs) and the clinical stage of osteosarcoma. The levels of miR-21, miR-221, miR-143, and miR-106a in osteosarcoma and normal bone tissues were analyzed by real-time polymerase chain reaction using SYBR Premix Ex TaqII. +other 31084400 hsa-mir-221 Osteosarcoma Moreover, the expression levels of miR-21 and miR-221 were positively correlated with the Enneking clinical stage and the presence of lung metastasis (P <0.05), while the expression levels of miR-143 and miR-106a showed a significant inverse and direct correlation respectively, with the tumor grade. CONCLUSIONS: The upregulation of miR-21, miR-221, and miR-106a, as well as the down-regulation of miR-143 were correlated with the pathological stage, tumor grade, and lung metastasis. +other 31084400 hsa-mir-21 Osteosarcoma Moreover, the expression levels of miR-21 and miR-221 were positively correlated with the Enneking clinical stage and the presence of lung metastasis (P <0.05), while the expression levels of miR-143 and miR-106a showed a significant inverse and direct correlation respectively, with the tumor grade. CONCLUSIONS: The upregulation of miR-21, miR-221, and miR-106a, as well as the down-regulation of miR-143 were correlated with the pathological stage, tumor grade, and lung metastasis. +other 31084400 hsa-mir-106a Osteosarcoma Moreover, the expression levels of miR-21 and miR-221 were positively correlated with the Enneking clinical stage and the presence of lung metastasis (P <0.05), while the expression levels of miR-143 and miR-106a showed a significant inverse and direct correlation respectively, with the tumor grade. CONCLUSIONS: The upregulation of miR-21, miR-221, and miR-106a, as well as the down-regulation of miR-143 were correlated with the pathological stage, tumor grade, and lung metastasis. +epigenetics 31082771 hsa-mir-362 Uterine Cervical Neoplasms The current study was undertaken to investigate the potential influence of methylation on miR +other 31082770 hsa-mir-5047 Uterine Cervical Neoplasms Ultimately, hsa_circ_0023404 and VEGFA were upregulated and showed positive correlation in cervical tumors, while miR-5047 was downregulated and showed negative correlation with hsa_circ_0023404 and VEGFA. CONCLUSIONS: Here, we reveal a novel role of hsa_circ_0023404 for cervical cancer metastasis and chemoresistance by regulating miR-5047. +lncRNA target 31082725 hsa-mir-5095 Carcinoma, Hepatocellular Our results revealed that HAGLROS is highly expressed in HCC, and its high level may correlate with the progression and development of HCC involving the processes of cell viability, apoptosis, and autophagy through the miR-5095/ATG12 axis and PI3K/AKT/mTOR signals. +genetics_knock down_promote 31082699 hsa-mir-21 Diabetes Mellitus Leukocyte- and platelet-rich fibrin as graft material improves microRNA-21 expression and decreases oxidative stress in the calvarial defects of diabetic rabbits. +lncRNA target 31082644 hsa-mir-212 Tuberculosis Quantitative real-time PCR verified the up expression of hsa-miR3p and its predicted target gene -MAPK1 which had low expression and was a major component of the PPI network, and MAPK1 expression was correlated with the clinicopathological characteristics of LTBI by receiver operating characteristic (ROC) curve analysis. +other 31082428 hsa-mir-148b Fibrosis The expression of lnc H19, NOX4 and miR-148b-3p in cirrhotic patients and hypoxic HHSEC were measured by RT-PCR. The present results indicated that the expressions of NOX4 mRNA and lnc H19 were increased but miR-148b-3p was decreased in both cirrhotic patients and hypoxic HHSEC. +circulation_biomarker_diagnosis_ns 31082423 hsa-mir-146a Neurodegenerative Diseases A MicroRNA (miR) based electrochemical method for quantification of miR-146a, a known biomarker for neurodegenerative disease, was developed. The unprocessed human serum sample was used as a real sample and the results fully confirm that the designed microRNA based biosensor is capable for detection of miR-146a as neurodegenerative disease biomarker. +other 31081939 hsa-mir-466a Rhinitis, Allergic Taken together, our findings highlight a new perspective on the role of miR-466a-3p in allergic rhinitis. +lncRNA target 31081880 hsa-mir-145 White Dot Syndromes CONCLUSIONS: TGF-beta1-induced human subconjunctival fibrosis was mediated by the expression of microRNA 143/145, mainly via SMAD-independent pathways. Inhibition of TGF-beta1-induced microRNA 143/145 expression in HTFs might represent a novel strategy to prevent subconjunctival fibrosis. +lncRNA target 31081880 hsa-mir-143 White Dot Syndromes CONCLUSIONS: TGF-beta1-induced human subconjunctival fibrosis was mediated by the expression of microRNA 143/145, mainly via SMAD-independent pathways. Inhibition of TGF-beta1-induced microRNA 143/145 expression in HTFs might represent a novel strategy to prevent subconjunctival fibrosis. +other 31081718 hsa-mir-197 Carcinoma, Endometrioid Taken together, we indicated that hsa_circ_0002577 could play critical functions by hsa_circ_0002577/miR-197/CTNND1/Wnt/beta-catenin signaling pathway, which served as a novel therapeutic application for EC treatment. +other 31081578 hsa-mir-93 Diabetic Retinopathy A reduced expression of miR5p was confirmed in the OIR model. +circulation_biomarker_diagnosis_ns 31081157 hsa-mir-515 Stomach Neoplasms These results suggest that serum miR3p is a novel potential biomarker for the detection of GC. +other 31081112 hsa-mir-140 Squamous Cell Carcinoma of Head and Neck The cell rescue experiment also indicated that there was a mutual regulation between SNHG20 and miR-140, which could together affect the malignant progression of LSCC. +genetics_overexpression_suppress 31081107 hsa-mir-34a Sepsis CONCLUSIONS: LncRNA HOTAIR overexpression can alleviate AKI in sepsis rats by inhibiting the apoptosis of kidney tissues by downregulating the miR-34a/Bcl-2 signaling pathway. +genetics_overexpression_suppress 31081107 hsa-mir-34a Acute Kidney Injury CONCLUSIONS: LncRNA HOTAIR overexpression can alleviate AKI in sepsis rats by inhibiting the apoptosis of kidney tissues by downregulating the miR-34a/Bcl-2 signaling pathway. +lncRNA target 31081105 hsa-mir-593 Hypertension, Pulmonary 5p promotes the development of hypoxic-induced pulmonary hypertension via targeting PLK1. +other 31081105 hsa-mir-593 Lymphohistiocytosis, Hemophagocytic 5p is lowly expressed in lung tissues of HPH rats. +other 31081105 hsa-mir-593 Hypoxia 5p expression in PASMCs decreased gradually with the prolongation of hypoxia induction. +genetics_knock down_suppress 31081103 hsa-mir-145 Diabetic Nephropathies Knockdown MALAT1 or ZEB2 inhibited HG-induced EMT and fibrosis, similar to miR-145 overexpression. +lncRNA target 31081101 hsa-mir-126 Glioma PATIENTS AND METHODS: miR-126 expression in cancer tissues, normal brain tissues, U87MG cells and normal astrocytes in glioma patients was quantitatively analyzed via quantitative reverse transcription-polymerase chain reaction (qRT-PCR). +lncRNA target 31081097 hsa-mir-23a Thyroid Cancer, Papillary CONCLUSIONS: MiR-23a was involved in the development of PTC via targeting CCNG1, which might provide a new prospect for PTC diagnosis and therapy. +other 31081096 hsa-mir-96 Thyroid Cancer, Papillary CONCLUSIONS: MiR5p was remarkably upregulated in PTC tumor tissues and cells. +genetics_knock down_promote 31081095 hsa-mir-497 Breast Neoplasms Further RT-PCR revealed that knockdown of LINC00473 suppressed the expressions of miR-497 in BC cells. CONCLUSIONS: Our data revealed that LINC00473 acted as a tumor promoter in BC and LINC00473/miR-497 axis may be a novel therapeutic strategy for this tumor. +genetics_overexpression_suppress 31081094 hsa-mir-199 Lung Neoplasms In addition, miRNA-199 overexpression expression model was constructed in LCa cell lines H1299 and SPCA1. +genetics_overexpression_promote 31081088 hsa-mir-411 Stomach Neoplasms Overexpression of miR-411 inhibits GC cell proliferation, colony formation, and migration, whereas the overexpression of SETD6 promotes cell proliferation, colony formation, and migration. +lncRNA target 31081086 hsa-mir-889 Colorectal Neoplasms By directly targeting DAB2IP, miR-889 served as a vital part in accelerating CRC cell proliferation. +lncRNA target 31081082 hsa-mir-424 Carcinoma, Hepatocellular CONCLUSIONS: LINC00511 plays an important role in the malignant progression of HCC via modulation of miR-424. +genetics_knock down_promote 31081077 hsa-mir-506 Ovarian Neoplasms Finally, we found that miRNA-506 knockdown reversed the regulatory effect of LINC01308 on the migratory and invasive abilities of OC cells. +genetics_overexpression_promote 31081075 hsa-mir-125a Ovarian Neoplasms However, the overexpression of microRNA-125a-5p reversed the promotive effect of SNHG14 on the proliferation and cell cycle of ovarian cancer cells. +lncRNA target 31081072 hsa-mir-646 Osteosarcoma Additionally, we found that ZFAS1 in OS cells up-regulated the expression of NOB1 through sponging miR-646, finally facilitating the growth of the OS cells. CONCLUSIONS: These results demonstrated that ZFAS1/miR-646/NOB1 axis might play an important role in the development of OS, and ZFAS1 and miR-646 can be considered as potential biomarkers for the diagnosis and treatment of OS. +lncRNA target 31081063 hsa-mir-335 Prostatic Neoplasms MicroRNA335 (miR335) was reported to suppress cell proliferation in prostate cancer (PC), a common malignancy in males. +genetics_overexpression_promote 31081061 hsa-mir-22 Stomach Neoplasms Furthermore, the overexpression of miR223p notably suppressed the proliferation, migration and invasion of GC cells, and these effects were enhanced by the downregulation of Snail1. +lncRNA target 31081054 hsa-mir-9 Osteosarcoma On the whole, the findings of this study substantiate that miR9 depletion suppresses cell proliferation by targeting p16 in OS and by mediating the activation of the ERK/p38/JNK pathway. +other 31081043 hsa-mir-155 Squamous Cell Carcinoma of Head and Neck However, the role of MIR155HG in laryngeal squamous cell carcinoma (LSCC) remains unclear. +other 31080555 hsa-mir-141 Pancreatic Carcinoma The results of our in-vitro studies revealed that miR-141 and miR-720 are involved in the process of epithelial to mesenchymal-transition in PDAC. +other 31080555 hsa-mir-720 Pancreatic Carcinoma The results of our in-vitro studies revealed that miR-141 and miR-720 are involved in the process of epithelial to mesenchymal-transition in PDAC. +other 31080555 hsa-mir-141 Carcinoma, Pancreatic Ductal The results of our in-vitro studies revealed that miR-141 and miR-720 are involved in the process of epithelial to mesenchymal-transition in PDAC. +other 31080555 hsa-mir-720 Carcinoma, Pancreatic Ductal The results of our in-vitro studies revealed that miR-141 and miR-720 are involved in the process of epithelial to mesenchymal-transition in PDAC. +other 31080363 hsa-mir-25 Leukemia, Myeloid, Acute The expression of miR-25 may contribute to the selection of the optimal treatment regimen between chemotherapy and allo-HCST for AML patients. +lncRNA target 31080348 hsa-mir-186 Pituitary Neoplasms Taken together, we discovered a novel mechanism by which miR-186/SKP2 axis modulates pituitary tumor cell proliferation through p27(Kip1)-mediated cell cycle alternation. +lncRNA target 31079353 hsa-mir-217 Diabetic Foot CONCLUSION: Inhibiting miR-217 could up-regulate HIF-1alpha/VEGF pathway to promote angiogenesis and ameliorate inflammation of DFU rats, thereby effectively advancing the healing of ulcerated area. +other 31079111 hsa-mir-216b Colorectal Neoplasms Supplementation with ectopic miR-216b-5p significantly compromised the oncogenic activities of LINC00265 in CRC cells. CONCLUSION: Our study highlighted the contribution of LINC00265/miR-216b-5p/TRIM44 signaling axis in CRC. +other 31078924 hsa-mir-148a Tuberculosis Regulation of miR-148a may provide a novel venue in development of therapies in tuberculosis. +other 31078924 hsa-mir-148a Mycobacterium Infections Together, miR-148a may function as an anti-inflammation modulator in responses to mycobacterial infection. +other 31078839 hsa-mir-182 Lung Neoplasms In this work, a novel label-free strategy for the ultrasensitive detection of miRNA-182 (a typical biomarker for lung cancer) based on MoS(2)/Ti(3)C(2) nanohybrids was suggested. +lncRNA target 31078780 hsa-mir-181c Breast Neoplasms Therefore, targeting NRF2/miR-181c could be an effective strategy to counteract HIForchestrated metabolic adaptation of hypoxic cancer cells. +lncRNA target 31078695 hsa-let-7 Pre-Eclampsia CONCLUSIONS: Let-7 silencing promoted proliferation, migration and invasion in EVT cells through the up-regulation of MDM4. +lncRNA target 31078585 hsa-mir-140 Diabetic Cardiomyopathies Thus, our results demonstrated that Catalpol could exert cardioprotective effect against DCM via Neat1/miR +genetics_overexpression_promote 31078266 hsa-mir-141 Colorectal Neoplasms In addition, Overexpression of miR +other 31078148 hsa-mir-376a Carcinoma, Hepatocellular To investigate the function of HDAC in hepatocellular carcinoma (HCC), this study used qRT-PCR to determine the expression levels of miR-376a and HDAC9 mNRA in HCC and para-cancerous tissues. These results suggest that the expression level of HDAC9 in HCC is abnormally high while the expression level of miR-376a is significantly decreased, indicating that HDAC9 may be a potential prognostic indicator of HCC. +other 31078131 hsa-mir-137 Schizophrenia Using the PGC2 secondary analysis schizophrenia case-control cohort (N = 29,125 cases and 34,836 controls), a robust polygenic signal was observed from gene sets based on TCF4, FMR1, upregulation from MIR137 and downregulation from CHD8. +genetics_overexpression_promote 31078043 hsa-mir-128 Breast Neoplasms In addition, we found that overexpression of miR +circulation_biomarker_diagnosis_ns 31077744 hsa-let-7i Infertility, Male Validation of two miRNAs (hsa-miR5p and hsa-let-7i-3p) and one piRNA (hsa-piR-26399) in an independent cohort confirmed a significant difference in circulating levels between subfertile and control men. +circulation_biomarker_diagnosis_ns 31077744 hsa-mir-542 Infertility, Male Validation of two miRNAs (hsa-miR5p and hsa-let-7i-3p) and one piRNA (hsa-piR-26399) in an independent cohort confirmed a significant difference in circulating levels between subfertile and control men. +lncRNA target 31077735 hsa-mir-98 Arthritis, Rheumatoid In this study, we constructed a tumor necrosis factor alpha (TNF-alpha)-induced synovial cell inflammatory model using human synoviocytes (HS) cell line to explore the function of miR-98 in rheumatoid arthritis (RA). In summary, our present study demonstrated that down-regulation of miR-98 inhibited the proliferation and promoted the apoptosis of TNF-alpha-stimulated HS partly by targeting IL-10 and regulating NF-kappaB signaling pathway, insinuating miR-98 as a candidate biomarker in RA. +epigenetics 31077718 hsa-mir-146a Osteoarthritis SIGNIFICANCE: Our results strongly suggest the impact of DNA methylation on miR +other 31077370 hsa-mir-219a Brain Injuries, Traumatic In particular, miR-219a-5p is a potentially valuable indicator of the diagnosis, prognosis of TBI and appears to regulate neuronal apoptosis and death. +other 31077198 hsa-mir-200c Ischemic Stroke Our aim of this study was to investigate the association of the rs12425791, rs11833579 and rs12904 in the binding site of miR-200c with the risk of IS. +other 31077182 hsa-mir-31 Breast Neoplasms In combination, miR-331 and miR-195 produced an AUC of 0.902, distinguishing metastatic from local breast cancer. +other 31077182 hsa-mir-31 Neoplasm Metastasis In combination, miR-331 and miR-195 produced an AUC of 0.902, distinguishing metastatic from local breast cancer. +other 31077182 hsa-mir-195 Breast Neoplasms In combination, miR-331 and miR-195 produced an AUC of 0.902, distinguishing metastatic from local breast cancer. +other 31077182 hsa-mir-195 Neoplasm Metastasis In combination, miR-331 and miR-195 produced an AUC of 0.902, distinguishing metastatic from local breast cancer. +other 31077090 hsa-mir-363 Thyroid Carcinoma, Anaplastic Reversely, miR3p expression was significantly upregulated by BI-847325 in both ATC cell lines. +lncRNA target 31076992 hsa-mir-499 Myocardial Infarction 5p/SOX6 pathway may present a potential therapeutic target for the treatment of AMI. +lncRNA target 31076630 hsa-mir-494 Carcinoma, Hepatocellular It suggested that aim at SIRT3/TGF-beta/SMAD signaling pathway through suppressing the miR-494 expression level, was a feasible therapy strategy for HCC. +other 31076615 hsa-mir-146a Ventricular Premature Complexes OMVs, with and without VCC-cargo, caused significantly increased levels of miR-146a. cholerae bacteria release OMVs that induce miR-146a in order to pave the way for colonization by reducing the strength of an epithelial innate immune defence reaction and also preventing inflammation in the mucosa that factors like VCC can evoke. +other 31076615 hsa-mir-146a Cholera The small intestinal epithelium of Vibrio cholerae infected patients expresses the immunomodulatory microRNAs miR-146a and miR-155 at acute stage of disease. +other 31076615 hsa-mir-155 Cholera The small intestinal epithelium of Vibrio cholerae infected patients expresses the immunomodulatory microRNAs miR-146a and miR-155 at acute stage of disease. +other 31076615 hsa-mir-146a Mucositis cholerae bacteria release OMVs that induce miR-146a in order to pave the way for colonization by reducing the strength of an epithelial innate immune defence reaction and also preventing inflammation in the mucosa that factors like VCC can evoke. +other 31076529 hsa-mir-7 Autoimmune Diseases The inositol lipid phosphatases PTEN and SHIP-1 play a crucial role in maintaining B cell anergy and are reduced in expression in B cells from systemic lupus erythematosus and type 1 diabetes patients, consequent to aberrant regulation by miRNA-7 and 155. +transcription factor target 31076402 hsa-mir-619 Hepatitis C 3p and their target OGT are previously undiscovered regulatory host factors for HCV assembly and infectivity. +other 31076282 hsa-mir-106b Carcinoma, Renal Cell CONCLUSIONS The results pointed out that the high expression of miR-106b-5p serves as an independent factor for predicting the worse prognosis of RCC patients. +transcription factor target 31075732 hsa-mir-141 Pre-Eclampsia 5p regulate ATF2 via effecting MAPK1/ERK2 signaling to promote preeclampsia. +genetics_overexpression_suppress 31075412 hsa-mir-613 Liver Neoplasms Furthermore, hepatoma cells with miR-613 overexpression performed more sensitivity to cisplatin or sorafenib treatment. +other 31075409 hsa-mir-181a Drug-Induced Kidney Injury RESULTS: DAPA was found to improve kidney function, oxidative stress markers, decrease apoptosis of renal tubular cells and increase miR-21 but decrease the expression of miR-181a with restoration of the renal architecture after 14days of treatment in GNT induced nephrotoxicity rat model. CONCLUSIONS: DAPA produced significant decrease in renal expression of miR-181a on the other hand it increased the expression of renal miR-21, this may introduce a novel early protective effect of DAPA against GNT-induced nephrotoxicity. +other 31075409 hsa-mir-21 Drug-Induced Kidney Injury RESULTS: DAPA was found to improve kidney function, oxidative stress markers, decrease apoptosis of renal tubular cells and increase miR-21 but decrease the expression of miR-181a with restoration of the renal architecture after 14days of treatment in GNT induced nephrotoxicity rat model. CONCLUSIONS: DAPA produced significant decrease in renal expression of miR-181a on the other hand it increased the expression of renal miR-21, this may introduce a novel early protective effect of DAPA against GNT-induced nephrotoxicity. +genetics_overexpression_promote 31075240 hsa-mir-486 Costello Syndrome Overexpression of miR +genetics_knock down_promote 31075235 hsa-mir-320c Osteoarthritis Overexpression of miR-320c and knockdown of beta-catenin had similar effects that the cartilage-specific genes were elevated and hypertrophy-related genes were down-regulated in OA chondrocytes. +tissue_expression_ns 31075234 hsa-mir-206 Squamous Cell Carcinoma of Head and Neck After the transfection of HNSCC cells with miR-206 mimic or si-LINC00460, the expression of STC2, AKT, ERK, as well as the extent of AKT, ERK phosphorylation all decreased, which facilitated the apoptosis and autophagy of HNSCC cells. +lncRNA target 31075231 hsa-let-7e Colorectal Neoplasms SIGNIFICANCE: Let-7e plays an important role as tumor suppressor miRNA in CRC probably through inhibition of DCLK1 expression. +genetics_overexpression_suppress 31075210 hsa-mir-211 Osteosarcoma 5p overexpression led to a significant increase in the apoptosis of osteosarcoma cell. +genetics_overexpression_promote 31074594 hsa-mir-4286 Carcinoma, Non-Small-Cell Lung In this study, we discover that the miR-4286 is overexpressed in NSCLC and negatively regulates the expression of PTEN. +genetics_GWAS 31074068 hsa-mir-881 Cleft Palate The present results imply that circRNA_0954-miRNA3p-PRKAR1alpha ceRNA network may cause dysfunctional palatal fusion and might facilitate the development of novel epigenetic biomarkers to treat CP in the future. +epigenetics 31074057 hsa-mir-124 Squamous Intraepithelial Lesions, Cervical The aim of this study was to prospectively evaluate the methylation status of CADM 1, MAL and hsa-miR-124 genes in high-grade squamous intraepithelial lesion (HSIL) liquid-based cytology (LBC) samples with a histological correlation. +genetics_knock down_suppress 31074036 hsa-mir-423 Myocardial Infarction Knockdown of MYBL2 was obviously reversed the roles of miR5p in apoptosis and mitochondrial dysfunction. +lncRNA target 31074018 hsa-mir-205 Hemangioma Among all candidate miRNAs, only miR-205 level was significantly downregulated whereas miR-15a was evidently upregulated in the hemangioma group. CONCLUSION: miR-15a and miR-205 had different expression in hemangioma, may be novel therapeutic targets in the treatment of hemangioma by targeting AKT3 and AKT1. +lncRNA target 31074018 hsa-mir-15a Hemangioma Among all candidate miRNAs, only miR-205 level was significantly downregulated whereas miR-15a was evidently upregulated in the hemangioma group. CONCLUSION: miR-15a and miR-205 had different expression in hemangioma, may be novel therapeutic targets in the treatment of hemangioma by targeting AKT3 and AKT1. +circRNA target 31074015 hsa-mir-342 Anorectal Malformations 5p/Wnt3a might serve as potential therapeutic targets for ARM. +lncRNA target 31073887 hsa-mir-200 Endometrial Neoplasms In the present study, we intend to determine whether Sestrin proteins 1, 2, and 3 (SESN1-3) are targets of microRNA-200 family (miR-200) in endometrial cancer (EC) Ishikawa, AN3CA, KLE, and RL 95-2 cell lines and to investigate how these potential interactions influence anoikis resistance of EC cell lines. Moreover, we have shown that SESN3 protein is a direct target of miR-200b, miR-200c, and miR-429 in Ishikawa, AN3CA, and KLE cell lines. +genetics_GWAS 31073863 hsa-mir-129-2 Stomach Neoplasms The mutation of the MIR129-2 gene is one of the major causes in many cancers, especially gastric cancer. +other 31073530 hsa-mir-224 Colorectal Neoplasms 5p) and five DEmRNAs (CXCR4, SMAD4, KRAS, FITM2, and PLAGL2) may be involved in the pathogenesis of RSCOAD and LSCOAD which may make a contribution for understanding mechanisms and developing therapeutic strategies for RSCOAD and LSCOAD. +other 31073530 hsa-mir-1 Colorectal Neoplasms 5p) and five DEmRNAs (CXCR4, SMAD4, KRAS, FITM2, and PLAGL2) may be involved in the pathogenesis of RSCOAD and LSCOAD which may make a contribution for understanding mechanisms and developing therapeutic strategies for RSCOAD and LSCOAD. +other 31073530 hsa-mir-155 Colorectal Neoplasms 5p) and five DEmRNAs (CXCR4, SMAD4, KRAS, FITM2, and PLAGL2) may be involved in the pathogenesis of RSCOAD and LSCOAD which may make a contribution for understanding mechanisms and developing therapeutic strategies for RSCOAD and LSCOAD. +lncRNA target 31073374 hsa-mir-203 Carcinoma, Hepatocellular MiR-203 transfection in HepG2 and Huh7 liver cancer cells targeted the 3'-UTR of MAT2A and MAT2B, inhibiting MAT2A and MAT2B mRNA levels and MATalpha2 and MATbeta2 protein expression. +lncRNA target 31073307 hsa-mir-181c Breast Neoplasms 5p and miR-181c could specifically target and suppress the MCAK gene expression in breast cancer cells. +lncRNA target 31073307 hsa-mir-485 Breast Neoplasms 5p and miR-181c could specifically target and suppress the MCAK gene expression in breast cancer cells. +other 31073299 hsa-mir-885 Ichthyosis, Lamellar We performed validation experiments for miR5p, by q-PCR, in a larger number of study subjects (OT = 8, CR = 12, HI = 12), as individual samples. +other 31073299 hsa-mir-27a Ear Diseases 3p, miR-27a-5p vs. +other 31073299 hsa-mir-885 Ear Diseases 5p could favor cell survival in OT by diminishing the levels of CRADD/RAIDD and CASP3. +other 31073299 hsa-mir-31 Ear Diseases 3p, miR-27a-5p vs. +other 31073224 hsa-mir-21 Stomatognathic Diseases In contrast, up-regulation of miR-21 was observed in both skin and oral wounds. +lncRNA target 31072914 hsa-mir-27a Osteosarcoma The present study aims to discuss the effects of miR-27a and its target gene secreted frizzled related protein 1 (SFRP1) on proliferation and invasion of human osteosarcoma cells via Wnt/beta-catenin signaling pathway. +lncRNA target 31072914 hsa-mir-27 Osteosarcoma The present study aims to discuss the effects of miR-27a and its target gene secreted frizzled related protein 1 (SFRP1) on proliferation and invasion of human osteosarcoma cells via Wnt/beta-catenin signaling pathway. +genetics_overexpression_promote 31072625 hsa-mir-145 Esophageal Squamous Cell Carcinoma Overexpression of miR-145 decreased REV3L mRNA and protein level in ESCC cell line KYSE150, while decreased miR-145 increased REV3L mRNA and protein level in esophageal epithelium cell line (HEEC). +other 31072448 hsa-mir-1224 Urinary Bladder Neoplasms Mechanistically, circCASC15 could act as miR5p sponge to activate the expression of CREB1 to promote cell proliferation in BC. +lncRNA target 31072421 hsa-mir-186 Cholangiocarcinoma In conclusion, miR-186 inhibited cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) through targeting Twist1 in human CCA. +transcription factor target 31072418 hsa-mir-146a Breast Neoplasms Our previous studies have shown that miR-146a can inhibit migration and invasion by targeting RhoA in breast cancer. Triptolide combined with miR-146a could improve the effect of triptolide treatment on breast cancer. +other 31072362 hsa-mir-167a Furunculosis In addition, we obtained some key genes from miRNA-mRNA pairs that may be associated with calyx abscission, including protein phosphatase 2C (psi-miR394a-HAB1), receptor-like protein kinase (psi-miR396a-5p-HERK1), cellulose synthase-like protein D3 (psi-miR827-CSLD3), beta-galactosidase (psi-miR858b-beta-galactosidase), SPL-psi-miR156j/157d, abscisic acid 8'-hydroxylase 1 (psi-miR396a-5p-CYP707A1) and auxin response factor (psi-miR160a-3p-ARF6, psi-miR167d-ARF18, psi-miR167a-5p-ARF25), etc. +other 31071531 hsa-mir-124 Carcinoma, Renal Cell Here we showed that miR-124 and maternally expressed gene 3 (MEG3) were both significantly reduced in RCC, and combined expression of miR-124 and MEG3 emerged as an independent prognostic factor in our RCC cohort. Our study identifies three crosstalks between miR-124 and MEG3, which provide a plausible link for these two ncRNAs in RCC. +lncRNA target 31071530 hsa-mir-338 Syphilis 3p/362-3p-E2F1 regulatory axis may serve as a prognostic marker and potential therapeutic target for LUAD. +lncRNA target 31071529 hsa-mir-146b Urinary Bladder Neoplasms Inhibition of miR-146b resulted in a significant inhibitory effect on the invasion of bladder cancer cells by reducing mmp2 mRNA transcription and protein expression. +genetics_overexpression_promote 31071528 hsa-mir-648 Bulimia Nervosa Collectively, the present results suggest that miR-3648 is overexpressed and plays an oncogenic role in mediation of BC invasion and metastasis through directing the TCF21/KISS1 axis, revealing miR-3648 as a potential biomarker for BC prognosis and a target for BC therapy. +other 31071316 hsa-mir-124 Squamous Cell Carcinoma of Head and Neck Therefore, XIST plays an important role in progression of LSCC by modulating the miREZH2 axis. +lncRNA target 31070483 hsa-mir-217 Osteosarcoma Conclusion: MiR-217 acts as a tumor suppressor in the development of OS. +lncRNA target 31070482 hsa-mir-21 Osteosarcoma Conclusion: Therefore, LncRNA LINC-PINT may inhibit cancer cell proliferation, invasion, and migration in osteosarcoma by downregulating miRNA-21. +genetics_overexpression_promote 31070305 hsa-mir-195 Adenocarcinoma of Lung Further analysis revealed that apelin is one of the functional target genes of miR-195, and the overexpression of apelin efficiently inhibits the promotion of cell proliferation and invasion mediated by miR-195 mimics in lung adenocarcinoma cells. +other 31069865 hsa-mir-518a Glioma What's more, circ-PITX1 sponges miR-518a-5p to release its repression on 3'-untranslated region (3'UTR) of interleukin 17 receptor D (IL17RD) messenger RNA to exert its oncogenic functions in GM cells proved by dual-luciferase reporter and rescue assays. +lncRNA target 31069831 hsa-mir-21 Hypertension Collectively, our results demonstrated that GAS5 inhibits PDGF-bb-induced VSMC proliferation and migration, partly through acting as a competing endogenous RNA of miR-21, and provided new evidence that GAS5 may serve as a potential therapeutic target for hypertension. +lncRNA target 31069828 hsa-mir-136 Osteosarcoma Our study demonstrates that the dysregulation of circRNA_100876 could induce apoptosis and arrest the cell cycle at G2/M stage, followed by suppression of cell proliferation in osteosarcoma, while silencing miR-136 could restore the cell growth. +transcription factor target 31069797 hsa-mir-206 Breast Neoplasms miR-206 is known to suppress breast cancer. Our study provides a broad insight into the breast cancer suppressive functions of miR-206. +genetics_overexpression_promote 31069760 hsa-mir-221 Carcinoma, Hepatocellular CONCLUSION: Overexpression of C1QTNF1-AS1 down-regulated miR +lncRNA target 31069607 hsa-mir-494 Cicatrix, Hypertrophic The suppression of microRNA-494 could eliminate its inhibition effect to PTEN and finally decrease the expression of collagen and inhibit hypertrophic scar formation. +other 31069235 hsa-mir-133a Diabetes Mellitus, Type 2 Thus, miR-133a could be a promising therapeutic candidate to prevent DMCM. +other 31069235 hsa-mir-133 Diabetes Mellitus, Type 2 Thus, miR-133a could be a promising therapeutic candidate to prevent DMCM. +other 31069235 hsa-mir-133 Cardiomyopathies Thus, miR-133a could be a promising therapeutic candidate to prevent DMCM. +other 31069235 hsa-mir-133a Cardiomyopathies Thus, miR-133a could be a promising therapeutic candidate to prevent DMCM. +circulation_biomarker_prognosis_ns 31068943 hsa-mir-181a Sveinsson Chorioretinal Atrophy Conclusions: Pre-transplantation plasmatic miR +circulation_biomarker_prognosis_ns 31068943 hsa-mir-155 Sveinsson Chorioretinal Atrophy Conclusions: Pre-transplantation plasmatic miR +circulation_biomarker_prognosis_ns 31068943 hsa-mir-181a Colorectal Neoplasms Conclusions: Pre-transplantation plasmatic miR +circulation_biomarker_prognosis_ns 31068943 hsa-mir-122 Primary Graft Dysfunction This study evaluated the capacity of a plasmatic miRNA panel (miR +circulation_biomarker_prognosis_ns 31068943 hsa-mir-155 Primary Graft Dysfunction This study evaluated the capacity of a plasmatic miRNA panel (miR +circulation_biomarker_prognosis_ns 31068943 hsa-mir-181a Primary Graft Dysfunction This study evaluated the capacity of a plasmatic miRNA panel (miR +circulation_biomarker_prognosis_ns 31068943 hsa-mir-181a Asymptomatic Infections This study evaluated the capacity of a plasmatic miRNA panel (miR +circulation_biomarker_prognosis_ns 31068943 hsa-mir-155 Asymptomatic Infections This study evaluated the capacity of a plasmatic miRNA panel (miR +circulation_biomarker_prognosis_ns 31068943 hsa-mir-155 Colorectal Neoplasms Conclusions: Pre-transplantation plasmatic miR +circulation_biomarker_prognosis_ns 31068943 hsa-mir-122 Asymptomatic Infections This study evaluated the capacity of a plasmatic miRNA panel (miR +circulation_biomarker_prognosis_ns 31068943 hsa-mir-148 Asymptomatic Infections This study evaluated the capacity of a plasmatic miRNA panel (miR +circulation_biomarker_prognosis_ns 31068943 hsa-mir-148 Colorectal Neoplasms This study evaluated the capacity of a plasmatic miRNA panel (miR +circulation_biomarker_prognosis_ns 31068943 hsa-mir-122 Sveinsson Chorioretinal Atrophy This study evaluated the capacity of a plasmatic miRNA panel (miR +circulation_biomarker_prognosis_ns 31068943 hsa-mir-122 Colorectal Neoplasms This study evaluated the capacity of a plasmatic miRNA panel (miR +circulation_biomarker_prognosis_ns 31068943 hsa-mir-148 Sveinsson Chorioretinal Atrophy This study evaluated the capacity of a plasmatic miRNA panel (miR +circulation_biomarker_prognosis_ns 31068943 hsa-mir-148 Primary Graft Dysfunction This study evaluated the capacity of a plasmatic miRNA panel (miR +genetics_GWAS 31068831 hsa-mir-34a Ischemic Stroke HIGHLIGHTS-MiR-34a rs2666433 polymorphism was associated with an increased risk of ischemic stroke.-The level of miR-34a was significantly up-regulated in ischemic stroke patients compared with controls, and patients with rs2666433 AA genotype had a higher level miR-34a than those with GG+GA genotypes.-Furthermore, increased level of homocysteine was showed in IS patients compared to controls, and in patients carrying the rs2666433AA compared to those carrying the rs2666433 GG+GA. +other 31068824 hsa-mir-195 Hemangioma Methods: In this study, we examined the expression of OIP5-AS1 and miR5p in hemangiomas patients. +other 31068820 hsa-mir-223 Atherosclerosis Furthermore, testing the direct effect of miR-223 and IGF-1R on late EPCs disclosed that these molecular factors improve late EPC functional properties in atherosclerosis in terms of stimulation of the proliferation and migration abilities. +lncRNA target 31068760 hsa-mir-429 Nasopharyngeal Carcinoma Methods TargetScan was used to predict the regulatory relationships of miR-429 and TLN1 in NPC cells. +other 31068698 hsa-mir-199a Myocardial Infarction Here we show that expression of human microRNA-199a in infarcted pig hearts can stimulate cardiac repair. +genetics_knock down_promote 31068677 hsa-mir-449 Mucocutaneous Lymph Node Syndrome In contrast, miR449 loss in other MCCs failed to enhance ciliary defects associated with TAp73 loss. +genetics_knock down_promote 31068677 hsa-mir-449 isolated cleft palate Although loss of miR449 alone led to a mild ciliary defect in the CP, more pronounced ciliary defects and hydrocephalus were observed in the brain lacking both TAp73 and miR449. +lncRNA target 31068580 hsa-mir-340 Ovarian Neoplasms Therefore, manipulating the expression of miR-340 or its target genes is a potential strategy in OC therapy. +lncRNA target 31068575 hsa-mir-34c Carcinoma, Hepatocellular In our previous report, we identified miR-34c-3p as an independent factor contributing to the carcinogenesis of hepatocellular carcinoma (HCC) by targeting NCK Associated Protein 1 (NCKAP1). +other 31068287 hsa-mir-21 Pre-Eclampsia CONCLUSIONS: Vitamin D may promote trophoblast cell migration and invasion to accelerate the development of preeclampsia by down-regulating the expression of miR-21. +epigenetics 31067838 hsa-mir-124 Uterine Cervical Diseases We aimed to determine whether the combination of CADM1, MAL and miR124 promoter methylation status assessed in histological samples can be used as a biomarker in the identification of transforming HSIL/CIN lesions. RESULTS: Significantly higher methylation levels of CADM1, MAL and miR-124 were found in HSIL/CIN2-3 and CC compared with normal and LSIL lesions. +lncRNA target 31067440 hsa-mir-410 Parkinson Disease This study determined miR-410 expression in the 6-hydroxydopamine (6-OHDA)-induced in vitro cellular model of PD and explored the mechanistic role of miR-410 in the modulation of neuronal cell viability and apoptosis. Collectively, this is the first study to demonstrate the neuroprotective effects of miR-410 in a 6-OHDA-induced cellular model of PD, and our data implied that miR-410 exerted its neuroprotective effects via regulating PTEN/AKT/mTOR signaling axis. +transcription factor target 31066587 hsa-mir-27b Arthritis, Rheumatoid Further in vitro studies demonstrated that miR-27b might inhibit chondrocyte apoptosis and thus attenuate RA development by directly inhibiting HIPK2 expression. +other 31066476 hsa-mir-370 Pneumonia Taken together, XIST may be involved in progression of cell inflammatory response, and XIST/miR3p/TLR4 axis thus may shed light on the development of novel therapeutics to the treatment of acute stage of pneumonia. +circulation_biomarker_diagnosis_ns 31066266 hsa-mir-10b hereditary diffuse gastric cancer Herein, we report a localized surface plasmon resonance sensor (LSPR) based on an enzyme-assisted target recycling system and a developed LSPR probe for the detection of gastric cancer relevant miRNAs, miR-10b. +other 31066253 hsa-mir-542 Scleroderma, Systemic 3p that is correlated with higher surviving expression levels might be a possible cause of apoptosis resistance in SSc fibroblasts, hence providing a new understanding of the disease pathogenesis. +lncRNA target 31066120 hsa-mir-143 Urinary Bladder Neoplasms We have previously shown that miR-143 suppresses cell growth by inhibiting RAS signaling networks in several cancers including BC. +lncRNA target 31066051 hsa-mir-497 Breast Neoplasms Hence, we conclude that HOXC13-AS, which is significantly upregulated in breast cancers, promoted cell proliferation through the suppressed miR +circulation_biomarker_diagnosis_ns 31066044 hsa-mir-24 ST Elevation Myocardial Infarction Small RNA sequencing indicated that the expression level of miR5p in peripheral blood EPCs of patients with STEMI was significantly lower compared with the healthy volunteers. +genetics_overexpression_suppress 31065679 hsa-mir-337 Tendinopathy 3p expression was also observed in both rat and human calcified tendons, and overexpressing miR +lncRNA target 31065520 hsa-mir-125b Carcinoma, Hepatocellular Data from clinical specimens and in vitro experiments confirm that the miR-125b-5p quantity is negatively correlated with progression, and the target protein that regulates the epithelial-mesenchymal transition (EMT)/cancer stem cells (CSC) potential in HCC is STAT3. +other 31065463 hsa-mir-34c Adenocarcinoma of Lung Among the ceRNAs identified, family with sequence similarity 83 member A (FAM83A), miR-34c-5p, KCNQ1OT1 and FLJ26245 were observed to be significantly associated with the overall survival of patients with LUAD. +genetics_overexpression_promote 31065369 hsa-mir-4319 Colorectal Neoplasms Overexpression of miR-4319 markedly reduced the proliferation of colorectal cancer cells and altered cell cycle distribution. +lncRNA target 31064980 hsa-mir-181a Myocardial Infarction MiR-181a-5p and miR-181a-3p mimetics retard atherosclerosis progression through blocking NF-kappaB activation and vascular inflammation by targeting TAB2 and NEMO, respectively. +lncRNA target 31064980 hsa-mir-181a Atherosclerosis MiR-181a-5p and miR-181a-3p mimetics retard atherosclerosis progression through blocking NF-kappaB activation and vascular inflammation by targeting TAB2 and NEMO, respectively. +circulation_biomarker_diagnosis_ns 31064890 hsa-mir-191 Ischemic Stroke MiR-191 was increased in the plasma of AIS patients, OGD/R HUVECs, and the plasma and brain of MCAO rats. Therefore, miR-191 may serve as a biomarker or a therapeutic target for AIS. +genetics_knock down_promote 31064820 hsa-mir-130a Non-alcoholic Fatty Liver Disease Overexpression of miR-130a and PPARgamma antagonist GW9662 inhibited lipogenesis and TG secretion, and PPARgamma agonist GW1929 reversed this change induced by miR-130a up-regulation.Conclusion: Knockdown of H19 alleviated hepatic lipogenesis via directly regulating miR-130a/PPARgamma axis, which is a novel mechanistic role of H19 in the regulation of NAFLD. +circulation_biomarker_diagnosis_ns 31064817 hsa-mir-378 Coronary Stenosis Moreover, it is indicated that miR-378 expression can effectively distinguish patients with or without coronary artery stenosis.Conclusions: Plasma miR-378 levels appear to be a promising non-invasive biomarker, but require to be further validated by a large cohort study in future. +circulation_biomarker_diagnosis_ns 31064817 hsa-mir-378 Coronary Artery Disease Moreover, it is indicated that miR-378 expression can effectively distinguish patients with or without coronary artery stenosis.Conclusions: Plasma miR-378 levels appear to be a promising non-invasive biomarker, but require to be further validated by a large cohort study in future. +genetics_GWAS 31064412 hsa-mir-340 Multiple Myeloma 5p is a tumor suppressor miRNA epigenetically silenced by promoter DNA methylation of its host gene in multiple myeloma. +circulation_biomarker_diagnosis_up 31064393 hsa-mir-20 Polycystic Ovary Syndrome CONCLUSION: The Expression serum levels of miR-320 were lower in PCOS compared to control and it could be a noninvasive diagnostic biomarker of PCOS. +circulation_biomarker_diagnosis_ns 31064356 hsa-mir-92a Colorectal Neoplasms Clinically, miR-92a-3p expression is significantly increased in CRC tissues and negatively correlated with the levels of FBXW7 and MOAP1 in CRC specimens, and high expression of exosomal miR-92a-3p in serum was highly linked with metastasis and chemotherapy resistance in CRC patients. +circulation_biomarker_diagnosis_ns 31064190 hsa-mir-200a Liver Neoplasms The aim of our study was to investigate whether the level of circulating miRNAs related to hypoxia (miR-21 and miR-210), liver injury (miR-122) and epithelial-mesenchymal transition (miR-200a) could reflect systemic effect of these intervention techniques. +circulation_biomarker_diagnosis_ns 31064190 hsa-mir-210 Liver Neoplasms The aim of our study was to investigate whether the level of circulating miRNAs related to hypoxia (miR-21 and miR-210), liver injury (miR-122) and epithelial-mesenchymal transition (miR-200a) could reflect systemic effect of these intervention techniques. +circulation_biomarker_diagnosis_ns 31064190 hsa-mir-21 Liver Neoplasms The aim of our study was to investigate whether the level of circulating miRNAs related to hypoxia (miR-21 and miR-210), liver injury (miR-122) and epithelial-mesenchymal transition (miR-200a) could reflect systemic effect of these intervention techniques. +circulation_biomarker_diagnosis_ns 31064190 hsa-mir-122 Liver Neoplasms The aim of our study was to investigate whether the level of circulating miRNAs related to hypoxia (miR-21 and miR-210), liver injury (miR-122) and epithelial-mesenchymal transition (miR-200a) could reflect systemic effect of these intervention techniques. +other 31063660 hsa-let-7 Biliary Atresia Conclusion: These results indicate that H19 plays a critical role in cholangiocyte proliferation and cholestatic liver injury in BA by regulating the S1PR2/SphK2 and let-7/HMGA2 axis. +circulation_biomarker_diagnosis_ns 31063535 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck This study may provide new insights into the role of plasma miR-21 as a biomarker for HNSCC, and plasma miR-21 would be useful for early detection of tumor recurrence after operation or chemoradiotherapy. +genetics_overexpression_suppress 31063232 hsa-mir-26a Breast Neoplasms Moreover, overexpression of miR-26a-5p inhibited RNF6/ERalpha/Bcl-xL axis in breast cancer cells. +transcription factor target 31062616 hsa-mir-27a Osteochondrodysplasias MiR-27a inhibitor and its control were transfected into HTM cells, and the influences of miR-27a inhibition in HTM cells stimulated with H2O2 and Sal were detected. +lncRNA target 31062614 hsa-mir-188 Leukemia, Myeloid, Acute And the effects of SBF2-AS1 suppression on AML cells progression could be abolished by miR5p inhibitors. +other 31062608 hsa-mir-15a Thyroid Neoplasms In conclusion, our study revealed UCA1/miR-15a axis implicated in thyroid cancer cells EMT, exposing a novel mechanism of thyroid cancer progression. +lncRNA target 31062436 hsa-mir-503 Triple Negative Breast Neoplasms The study in vitro suggested MIR503HG inhibits cell migration and invasion via miR-103/OLFM4 axis in triple negative breast cancer. +exosome 31062357 hsa-mir-92a Cancer-Associated Cachexia These results demonstrate that adipogenesis inhibition by tumor-derived exosomes, mainly exosomal microRNAs like miR-92a-3p, are the main mediators for CAC. +circulation_biomarker_diagnosis_down 31061410 hsa-mir-130b Carcinoma, Non-Small-Cell Lung Furthermore, TIMP-2 concentrations in serum were inversely correlated with relative miR-130b expression in tumor tissues from the same patients with NSCLC. +genetics_overexpression_suppress 31061316 hsa-mir-146a Sarcoma, Ewing We also detected the expression of interleukin-1 receptor-associated protein kinases-1 (IRAK1) and tumor necrosis factor receptor-associated factor 6 (TRAF6) and nuclear factor-kappaB (NF-kappaB) p65 using Western blotting and immunohistochemistry, which indicated the expression of IRAK1, TRAF6 and NF-kappaB p-p65/p65 increased in the brain of SE rats, and overexpression of miR-146a-5p could downregulate the expression of IRAK1, TRAF6, NF-kappaB p-p65/p65 and P-gp. +lncRNA target 31061316 hsa-mir-146a Status Epilepticus We investigated the impact of miR-146a-5p on the expression of P-gp in status epilepticus rat model. Our study indicated that miR-146a-5p may decrease the expression of P-gp in status epilepticus rats via NF-kappaB signaling pathway. +other 31061247 hsa-mir-34c Pituitary Neoplasms We observed that miR-34c-3p was significantly downregulated in our PRLPA samples (p < 0.01), along with miR-34b-5p, miR-378 and miR5p (all p < 0.05). +other 31061247 hsa-mir-378 Pituitary Neoplasms We observed that miR-34c-3p was significantly downregulated in our PRLPA samples (p < 0.01), along with miR-34b-5p, miR-378 and miR5p (all p < 0.05). +other 31061247 hsa-mir-34b Pituitary Neoplasms We observed that miR-34c-3p was significantly downregulated in our PRLPA samples (p < 0.01), along with miR-34b-5p, miR-378 and miR5p (all p < 0.05). +transcription factor target 31061247 hsa-mir-124 Pituitary Neoplasms We observed that the tumor suppressive miR3p was downregulated in both NFPAs and GHPAs. +other 31061236 hsa-mir-29b Pancreatic Carcinoma By combination of results from expression, survival and correlation analysis demonstrated that MMP9/ITGB1-miR-29b-3p-HCP5 competing endogenous RNA (ceRNA) sub-network was linked to prognosis of pancreatic cancer. +other 31061003 hsa-mir-155 Liver Failure, Acute CONCLUSION: These data demonstrate that miR-155 regulates TNF-mediated hepatocyte apoptosis in ALF, which provides some useful information in both basic and clinical researches. +circulation_biomarker_diagnosis_ns 31060996 hsa-mir-551b Stomach Neoplasms The area under the curve for serum miR-551b-3p distinguishing patients with GC from healthy individuals was 0.860 (95% CI: 0.787-0.933, p=0.000), with a specificity of 96.2% and a sensitivity of 70%. +lncRNA target 31060778 hsa-mir-126 Reperfusion Injury, Cerebral Ischemia Thereby, these results revealed a new molecular mechanism of lncRNA CHRF through targeting miR-126/SOX6 signaling to modulate ischemic neuronal injury, providing solid evidence to develop promising therapeutic strategies against cerebral ischemic stroke. +genetics_overexpression_promote 31060678 hsa-mir-365 Uterine Cervical Neoplasms Results qPCR results showed that compared with the normal cervical cell HcerEpic,the expressions of miR-365 in CIN1,CIN2-3,and cervical cancer tissues gradually decreased with the increased pathologic grade,and its expressions also decreased in different cervical cancer cell lines.The luciferase reporter gene assay confirmed that ELF4 was the direct target of miR-365.Western blot showed that the expression of ELF4 increased in all three cervical cancer cell lines compared with normal cervical epidermal cell(P=0.013,P=0.002,P=0.004).Immunohistochemistry showed that ELF4 expression was up-regulated in CIN and cervical cancer tissues.CCK8 assay showed that overexpression of miR-365 inhibited cell proliferation,while inhibition of miR-365 promoted the proliferation of three cervical cancer cells(P<0.05).Further analysis confirmed that there was a negative correlation between the expression levels of miR-365 and ELF4 in CIN2-3 and SCC(r=-0.351,P=0.045;r=-0.349,P=0.035).Clinical analysis showed that the expressions of both miR-365 and ELF4 were correlated with tumor size,pathological grade,and clinical stage in SCC(all P < 0.05).Conclusion The decreased expression of miR-365 in human cervical cancer cells relieves its inhibitory effect on ELF4,which promotes the proliferation of cervical cancer cells and the formation of tumor. +other 31060525 hsa-mir-944 Uterine Cervical Neoplasms Moreover, the expression levels of miR-944 in cervical cancer cell lines and FFPE tissues with human papillomavirus (HPV) infection were significantly higher compared to those without HPV infection (P < 0.01 and P = 0.02). +epigenetics 31060424 hsa-mir-29b Carcinoma, Hepatocellular We determined the effect of FA on global DNA methylation as well as a mechanism of FA-induced changes in DNA methylation by transcriptional (promoter methylation), post-transcriptional (miR-29b) and post-translational (ubiquitination) regulation of DNMTs and MBD2 in the human hepatocellular carcinoma (HepG2) cell line. +genetics_knock down_promote 31060006 hsa-mir-506 Pancreatic Carcinoma Mechanistically, the luciferase reporter assay showed that miR-506 targeted the 3' untranslated region of matrix metalloproteinase (MMP)-2/16, and miR-506 overexpression and rosmarinic acid treatment suppressed the expression of MMP2/16 in pancreatic cancer cells. +circulation_biomarker_diagnosis_up 31059711 hsa-mir-144 Nasopharyngeal Carcinoma Collectively, the effect of TPL on S phase arrest in human NPC cells is likely to enhance the p85alpha-PTEN interaction in the plasma membrane by suppressing miR-144 expression, resulting in the attenuation of cyclin A-p-CDK2 (Thr 39) complex formation via Akt inactivation. +lncRNA target 31059108 hsa-mir-186 Glioblastoma In conclusion, the present study demonstrated that downregulation of miR1865p may contribute to the proliferation and drug resistance of glioblastoma cells via the regulation of Twist1 expression. +other 31059106 hsa-mir-124 Laryngeal Neoplasms miR1, miR33b, miR124, HOTAIR, HCG4 and EMX2OS may be novel biomarkers of recurrent laryngeal cancer, and HCG4miR33b, HOTAIRmiR1MAGEA2 and EMX2OSmiR124CALCA/GABRG2 may be associated with the molecular mechanisms regulating recurrent laryngeal cancer. +other 31059106 hsa-mir-1 Laryngeal Neoplasms miR1, miR33b, miR124, HOTAIR, HCG4 and EMX2OS may be novel biomarkers of recurrent laryngeal cancer, and HCG4miR33b, HOTAIRmiR1MAGEA2 and EMX2OSmiR124CALCA/GABRG2 may be associated with the molecular mechanisms regulating recurrent laryngeal cancer. +genetics_knock down_suppress 31059102 hsa-mir-320d Lymphoma, Large B-Cell, Diffuse In conclusion, CDK6 overexpression in DLBCL may result from miRNA320d downregulation and subsequent loss of inhibition of cell proliferation, suggesting that miRNA320d may be a potential therapeutic target for the treatment of DLBCL with high CDK6 expression. +genetics_GWAS 31059093 hsa-mir-137 Atrial Fibrillation These findings collectively provide support that VKORC1 is a direct target of miR137 and the miR137 rs2660304 polymorphism is associated with warfarin maintenance dose in patients with atrial fibrillation. +lncRNA target 31059092 hsa-mir-1246 Neuroblastoma In addition, the upregulated miR1246 target, regulated the expression of TRPV1, indicating that miR1246 may be a new therapeutic target for pancreatic pain. +lncRNA target 31059087 hsa-mir-195 Parkinson Disease Certain microRNAs (miRs) are key factors in inhibiting or stimulating inflammation during the occurrence and development of PD, among which miR195 may be a potential crucial biomarker. The present results suggest that miR195 is a potential therapeutic target for PD. +other 31059086 hsa-mir-214 Lung Neoplasms In the present study, the biological functions and potential mechanisms of miR214 were determined, as well as its correlation with HIF1 signaling in nonsmall cell lung cancer (NSCLC) cells. +lncRNA target 31059061 hsa-mir-384 Colorectal Neoplasms The present study demonstrated that luteolin exerts anticancer effects against CRC cells by modulating PTN via miR384 expression suggested that PTN may serve as a promising candidate for therapeutic applications in CRC treatment. +genetics_knock down_promote 31059060 hsa-mir-136 Carcinoma, Non-Small-Cell Lung Gain and lossoffunction experiments confirmed that miR1365p reversed the promoting effects of NORAD in NSCLC. +lncRNA target 31059054 hsa-mir-216a Cardiomyopathies In conclusion, miR216a was involved in the regulation of TGFbetainduced myofibroblast transdifferentiation, suggesting that targeting miR216a may aid in developing effective interventions for the treatment of cardiac fibrosis. +lncRNA target 31059052 hsa-mir-125b psoriasis 1 The aim of the present study was to investigate the mechanism by which microRNA125b (miR125b) inhibits the activation of the bromodomaincontaining protein 4 (BRD4)/Notch signaling pathway in psoriasis. Therefore, miR125b may be a biomarker and potential therapeutic target for psoriasis treatment. +genetics_knock down_suppress 31059047 hsa-mir-199 Osteochondritis Dissecans The overexpression of miR199a5p in the OGD/R cell model significantly decreased the viability and increased the lactate dehydrogenase leakage of cells; whereas knockdown of miR1995p induced the opposing effects. Additionally, inhibition of miR1995p significantly attenuated OGD/Rinduced alterations to the mitochondrial transmembrane potential (DeltaPsim) and increases in the apoptosis of cells. +circulation_biomarker_diagnosis_ns 31059047 hsa-mir-199a Myocardial Infarction In the present study, it was revealed that miR199a5p expression was significantly increased in the plasma of patients with acute myocardial infarction and in a H9c2 cell model of oxygenglucose deprivation and reperfusion (OGD/R) via reverse transcriptionquantitative PCR. +other 31059047 hsa-mir-199a Myocardial Reperfusion Injury MicroRNAs (miRs) have been identified as critical regulatory molecules in myocardial ischemia/reperfusion injury; however, the exact expression profile of miR199a5p in reperfusion injury and the underlying pathogenic mechanisms remain unclear. +genetics_knock down_promote 31059047 hsa-mir-199a Osteochondritis Dissecans Similarly, treatment with LiCl (a specific inhibitor of pGSK3beta) also attenuated the protective effects of miR199a5p knockdown on OGD/Rinjured H9c2 cells. +genetics_overexpression_suppress 31059039 hsa-mir-486 Cicatrix, Hypertrophic To investigate the role of miR4865p in HS formation, miR4865p was overexpressed in hHSFs through transfection with miR4865p mimics. +lncRNA target 31059033 hsa-mir-1 lung squamous cell carcinoma In summary, miR1 was significantly downregulated in LUSC, suggesting a novel and promising noninvasive biomarker for diagnosing LUSC, and miR1 was involved in LUSC progression via a number of significant pathways. +other 31059023 hsa-mir-148a Sepsis Our analysis showed that the members of the miR148 family (miR148A/B and miR152) are candidate biomarkers for sepsis. +other 31059023 hsa-mir-152 Sepsis Our analysis showed that the members of the miR148 family (miR148A/B and miR152) are candidate biomarkers for sepsis. +other 31059023 hsa-mir-148b Sepsis Our analysis showed that the members of the miR148 family (miR148A/B and miR152) are candidate biomarkers for sepsis. +other 31059017 hsa-mir-431 Respiratory Distress Syndrome, Newborn Our previous study demonstrated that miR431 was differentially expressed between infants with RDS and infants without RDS using microarray analysis. +lncRNA target 31059003 hsa-mir-144 Pre-Eclampsia In the current study, the aim was to investigate the expression of miR1443p in the placenta of patients with preeclampsia and normal placentas, and to explore the potential target genes. +lncRNA target 31059001 hsa-mir-199a Squamous Cell Carcinoma of Head and Neck Collectively, these data indicated that miR199a5p may inhibit the migration and invasion of OSCC cells via targeting the EMTrelated transcription factor SOX4, thus suggesting that miR199a5p may serve as a prognostic biomarker and therapeutic target in the treatment of OSCC. +epigenetics 31058984 hsa-mir-124-2 Acquired Immunodeficiency Syndrome Specimens were tested for 37 human papillomavirus (HPV) types and for FAM19A4 and microRNA124-2 promoter methylation. +other 31058973 hsa-mir-29a Diabetes, Gestational Ten miRNAs (miR122-5p; miR132-3p; miR1323; miR136-5p; miR182-3p; miR210-3p; miR29a-3p; miR29b-3p; miR342-3p, and miR-520h) showed significantly higher levels in GDM cases than in controls (P C polymorphism may have a CAL-related relationship with KD susceptibility that has not been previously revealed. +genetics_GWAS 31043452 hsa-mir-608 Coronary Disease The present study demonstrated that the miRNA-608 rs4919510 G>C polymorphism may have a CAL-related relationship with KD susceptibility that has not been previously revealed. +other 31043318 hsa-mir-1 Cardiovascular Diseases Importantly, miR-1 levels at the end of the operation positively correlated with intensive care stay (P < .001), early severe cardiovascular events (P = .01), and with high vasoactive-inotrope score (P = .001) and ventilation index (P < .001), suggesting that miR-1 could accelerate the identification of patients with cardiopulmonary bypass-related ischemic complications, requiring more intensive support. +transcription factor target 31043087 hsa-mir-103 Hypoxia To sum up, 6G protected hypoxia-stimulated PC-12 cells through miR +genetics_knock down_promote 31042421 hsa-mir-140 Sepsis We initially induced the model of sepsis by endotoxin, and then ectopic expression and knockdown experiments were performed to explore the functional role of miR-140 in sepsis. +transcription factor target 31042325 hsa-mir-34a Prostatic Neoplasms Inhibition of miR-34a activated beta-catenin/c-myc axis, altered cell cycle-related genes expression and significantly suppressed the antiproliferation effect of curcumin in prostate cancer cells. +other 31042008 hsa-mir-21 Pulpitis However, the involvement of miR-21 in pulpal inflammation and the precise mechanisms of anti-inflammatory reactions induced by miR-21 remain unclear. +other 31041827 hsa-mir-455 Duane Retraction Syndrome The study gives evidence that miR5p may serve as a new potential therapeutic agent for DR treatment. +lncRNA target 31041680 hsa-mir-377 Ovarian Neoplasms 3p inhibited growth and invasion of ovarian cancer cells by targeting JAG1. +lncRNA target 31040894 hsa-mir-103a Stomach Neoplasms METHODS: Quantitative polymerase chain reaction (qPCR) by TaqMan((R)) assay was used to quantify the RNA transcript levels of TNF-alpha signaling pathway (TNF, TNFR1, TNFR2, TRADD, TRAF2, CFLIP, NFKB1, NFKB2, CASP8, CASP3) and miRNAs that targets genes from this pathway (miR-19a, miR-34a, miR-103a, miR-130a, miR-181c) in 30 GC fresh tissue samples. When the samples were stratified by histological type, the expression of miR-103a and miR-130a was significantly increased in the diffuse-type of GC compared to the intestinal-type. +lncRNA target 31040894 hsa-mir-130a Stomach Neoplasms METHODS: Quantitative polymerase chain reaction (qPCR) by TaqMan((R)) assay was used to quantify the RNA transcript levels of TNF-alpha signaling pathway (TNF, TNFR1, TNFR2, TRADD, TRAF2, CFLIP, NFKB1, NFKB2, CASP8, CASP3) and miRNAs that targets genes from this pathway (miR-19a, miR-34a, miR-103a, miR-130a, miR-181c) in 30 GC fresh tissue samples. When the samples were stratified by histological type, the expression of miR-103a and miR-130a was significantly increased in the diffuse-type of GC compared to the intestinal-type. +lncRNA target 31040714 hsa-mir-101 Lymphoma, Large B-Cell, Diffuse CONCLUSION: These data indicate that miR-101 regulates cell proliferation and apoptosis by targeting KDM1A, which provides a potential therapeutic for DLBCL patients. +lncRNA target 31040704 hsa-mir-17 Stomach Neoplasms 5p can be delivered to immature DCs, and they significantly inhibited LPS-stimulated phenotypic maturation by diminishing the expression of maturation markers (MHC II, CD80 and CD86 molecules). +other 31040703 hsa-mir-34a Colonic Neoplasms CONCLUSION: lncRNA KCNQ1OT1 promoted the chemoresistance of colon cancer by sponging miR-34a, thus upregulating the expressions of Atg4B and enhancing protective autophagy. +genetics_overexpression_suppress 31040702 hsa-mir-99b Carcinoma, Non-Small-Cell Lung Overexpression of FZD8 partially abolished the effects of miR-99b-5p mimic on NSCLC cell behaviors. +circulation_biomarker_diagnosis_down 31039814 hsa-mir-23a Myocardial Infarction, Acute CONCLUSIONS For the first time, this study identify a unique circulating miRNA signature (miR +circulation_biomarker_diagnosis_down 31039814 hsa-mir-24 Acute Kidney Injury CONCLUSIONS For the first time, this study identify a unique circulating miRNA signature (miR +circulation_biomarker_diagnosis_down 31039814 hsa-mir-24 Myocardial Infarction, Acute CONCLUSIONS For the first time, this study identify a unique circulating miRNA signature (miR +circulation_biomarker_diagnosis_down 31039814 hsa-mir-145 Myocardial Infarction, Acute CONCLUSIONS For the first time, this study identify a unique circulating miRNA signature (miR +circulation_biomarker_diagnosis_down 31039814 hsa-mir-145 Acute Kidney Injury CONCLUSIONS For the first time, this study identify a unique circulating miRNA signature (miR +circulation_biomarker_diagnosis_down 31039814 hsa-mir-23a Acute Kidney Injury CONCLUSIONS For the first time, this study identify a unique circulating miRNA signature (miR +genetics_overexpression_promote 31039290 hsa-mir-873 Colonic Neoplasms Overexpression or silencing of TUSC3 could partially reverse the effects of the overexpression or repression of miR +lncRNA target 31039163 hsa-mir-29b Heart Defects, Congenital Downregulation of miRNAs (miR-29b, miR-405, and miR-19) associated with cardiomyopathy and cardiac fibrosis was observed. Moreover, the upregulation of miR-29b targets COL1A2 and IGF1, indicated that ADAR2 might be involved in cardiac myopathy. +lncRNA target 31038819 hsa-mir-124 Retinoblastoma Thus, NEAT1 promotes RB progression by sponging miR-124, providing a therapeutic target for RB. +lncRNA target 31038787 hsa-mir-193a Leukemia, Myeloid, Acute We also investigate the association of 12p chromosomal on the expression of HOTAIR, miRNA-193a, and c-kit gene as targeting genes for HOTAIR in AML. +lncRNA target 31038780 hsa-mir-103 Nasopharyngeal Carcinoma CONCLUSIONS: MiR-103 might play a key role in NPC carcinogenesis by targeting TIMP-3 and affecting the Wnt/beta-catenin pathway. +genetics_overexpression_suppress 31038761 hsa-mir-199a Glioma Overexpression of MAGT1 reversed the effects of miR-199a-5p on glioma cell behaviors. +lncRNA target 31038546 hsa-mir-142 Ovarian Neoplasms Artesunate enhanced the pro-apoptotic effects of Th1 cells on ovarian cancer via the miR-142/Sirt1 pathway. Artesunate promoted Th1 differentiation from CD4+ T cells by down-regulating Sirt1 through miR-142, thereby enhancing cell apoptosis in ovarian cancer. +lncRNA target 31038361 hsa-mir-29a Uterine Cervical Neoplasms Moreover, miR-29a promoted cell apoptosis, suppressed proliferation, inhibited migration and invasion via inactivation of NF-kappaB signaling pathway in cervical cancer cells. +other 31038266 hsa-mir-27a Carcinoma, Hepatocellular Next, the antineoplastic effect of miR-27a-3p on cell growth and motility of HCC was confirmed. CONCLUSIONS: In a word, DANCR promotes HCC development and induces EMT by decoying miR-27a-3p to regulate ROCK1/LIMK1/COFILIN1 pathway. +transcription factor target 31038242 hsa-mir-144 Lung Neoplasms 3p could effectively suppress TGF-beta1-induced aggressive lung cancer cells by regulating Src expression. +other 31038082 hsa-mir-4513 Coronary Artery Disease CONCLUSION: It is concluded that CT genotype and T allele of microR-4513 rs2168518 is strongly associated with increased susceptibility to CAD. +lncRNA target 31038078 hsa-mir-4301 Carcinoma, Non-Small-Cell Lung When miR-4301 was transfected in lung cancer cells, their cell proliferation was suppressed and apoptosis induced. +circulation_biomarker_diagnosis_up 31037985 hsa-mir-128 Ischemic Stroke From the above results, we concluded that the upregulation of miR-128 in circulating lymphocytes of acute ischemic stroke patients was correlated with stroke severity and miR-128 antagomir exacerbated ischemia-reperfusion induced neuronal injury via promoting neuronal cell cycle reentry. +circulation_biomarker_diagnosis_up 31037985 hsa-mir-128 Stroke From the above results, we concluded that the upregulation of miR-128 in circulating lymphocytes of acute ischemic stroke patients was correlated with stroke severity and miR-128 antagomir exacerbated ischemia-reperfusion induced neuronal injury via promoting neuronal cell cycle reentry. +transcription factor target 31037734 hsa-mir-431 Hirschsprung Disease 5p promoted proliferation of ENCCs via targeting LRSAM1, which provides an innovative and candidate target for treatment of HSCR. +lncRNA target 31037501 hsa-mir-153 Reperfusion Injury MiR-153 has been previously shown to be involved in regulating neuron survival during cerebral ischemia/reperfusion (I/R) injury. Our study indicates that the inhibition of miR-153 or restoration of Nrf2 may serve as a potential therapeutic strategy for ischemia/reperfusion injury prevention. +circulation_biomarker_prognosis_down 31037126 hsa-mir-29c Esophageal Neoplasms Results: MiR-29c, under the regulatory control of STAT5A, was frequently downregulated in tumor and serum samples of patients with ESCC, and the expression level was correlated with overall survival. +other 31036632 hsa-mir-16 Osteitis Deformans Ancient miRNAs were remarkably preserved in an osteosarcoma from a skeleton with extensive disease, with miR-16 expression consistent with that reported in contemporary PDB-associated bone tumors. +circulation_biomarker_diagnosis_ns 31036605 hsa-mir-20 Polycystic Ovary Syndrome The plasma microRNA (miRNA)-24, miR-320 levels were measured by reverse transcription fluorescent quantitative PCR (RT-qPCR).Results: The risk of PCOS in C allele carriers of RAB5B gene rs1045435 locus was 3.91 times higher than that of G allele. +lncRNA target 31036603 hsa-mir-1915 Stomach Neoplasms 3p possibly contributes to the development and progression of gastric cancer by inhibiting the anti-apoptotic protein Bcl-2. +lncRNA target 31036506 hsa-mir-135b Parkinson Disease In summary, miR-135b played a protective role in Parkinson's disease via inhibiting pyroptosis by targeting FoxO1. +other 31036495 hsa-mir-155 Carcinoma, Hepatocellular In this study, we evaluate the role of the novel oncogenic microRNA (miRNA) miR-155 in the anti-proliferative effects of pegylated interferon-alpha (PEG-IFN) on HCC cells. CONCLUSIONS: The anti-proliferative effects of PEG-IFN on HCC are at least partially attributable to the downregulation of miR-155. +transcription factor target 31036418 hsa-mir-142 Squamous Cell Carcinoma of Head and Neck CONCLUSION: Three genes (VCAM1, UBD, and RPA2), two miRNAs (miR-107 and miR3p), and four pathways (p53, PI3K-Akt, autophagy, and transcription dysregulation in cancer) were identified to play critical roles in distinguishing HPV-positive OPSCC from HPV-negative OPSCC. +transcription factor target 31036418 hsa-mir-107 Squamous Cell Carcinoma of Head and Neck CONCLUSION: Three genes (VCAM1, UBD, and RPA2), two miRNAs (miR-107 and miR3p), and four pathways (p53, PI3K-Akt, autophagy, and transcription dysregulation in cancer) were identified to play critical roles in distinguishing HPV-positive OPSCC from HPV-negative OPSCC. +circulation_biomarker_diagnosis_up 31035988 hsa-mir-503 Diabetes Mellitus As MiR-503 is stable enough in blood it can be used as a potential diagnostic marker of an ischemic stroke in diabetic patient. +circulation_biomarker_diagnosis_up 31035988 hsa-mir-503 Ischemic Stroke As MiR-503 is stable enough in blood it can be used as a potential diagnostic marker of an ischemic stroke in diabetic patient. +lncRNA target 31035970 hsa-mir-140 Wilms Tumor 5p participates in the progression of Wilms' tumor by targeting the TGFBRI/SMAD2/3 and the IGF-1R/AKT signaling pathways. +other 31035807 hsa-mir-155 Wounds and Injuries Nanocarrier were prepared and assessed for their effect on growth of 3T3 fibroblast cells, cell migration, wound healing rate and expression of miR-155, TGF-beta1 and SMAD 1,2 genes. This nanocarrier changed expression of miR-155 and TGF-beta1 towards faster healing of wounds. +lncRNA target 31034943 hsa-mir-34a Carcinoma, Hepatocellular Thus, miR-34a-5p may inhibit the proliferation of HCC cells via regulating MCM2 expression. +circulation_biomarker_diagnosis_up 31034651 hsa-mir-155 Peptic Ulcer Reverse-transcription polymerase chain reaction (RT-PCR) was used to detect the expression of microRNA-155a (miR-155a) and miR-146a in the blood of the patients and to confirm whether CYYY could cure peptic ulcer through regulation of miR-155a and miR-146a. CONCLUSION: CYYY was a highly effective therapeutic method for peptic ulcer patients by inhibiting the activation of the TLR4/NF-kappaB signal pathway and suppressing the expression of miR-155a and miR-146a. +circulation_biomarker_diagnosis_up 31034651 hsa-mir-146a Peptic Ulcer Reverse-transcription polymerase chain reaction (RT-PCR) was used to detect the expression of microRNA-155a (miR-155a) and miR-146a in the blood of the patients and to confirm whether CYYY could cure peptic ulcer through regulation of miR-155a and miR-146a. CONCLUSION: CYYY was a highly effective therapeutic method for peptic ulcer patients by inhibiting the activation of the TLR4/NF-kappaB signal pathway and suppressing the expression of miR-155a and miR-146a. +other 31034522 hsa-mir-423 Fetal Growth Retardation 5p and miR-484 had decreased expression in gestational protein-restricted left ventricle. +other 31034522 hsa-mir-182 Fetal Growth Retardation 5p and miR-484 had decreased expression in gestational protein-restricted left ventricle. +other 31034522 hsa-mir-484 Fetal Growth Retardation 5p and miR-484 had decreased expression in gestational protein-restricted left ventricle. +other 31034522 hsa-mir-127 Fetal Growth Retardation 5p and miR-484 had decreased expression in gestational protein-restricted left ventricle. +other 31034522 hsa-mir-181c Fetal Growth Retardation 5p and miR-484 had decreased expression in gestational protein-restricted left ventricle. +other 31034522 hsa-mir-142 Fetal Growth Retardation 5p and miR-484 had decreased expression in gestational protein-restricted left ventricle. +other 31034522 hsa-let-7b Fetal Growth Retardation 5p and miR-484 had decreased expression in gestational protein-restricted left ventricle. +other 31034522 hsa-mir-383 Fetal Growth Retardation 5p and miR-484 had decreased expression in gestational protein-restricted left ventricle. +other 31034522 hsa-mir-188 Fetal Growth Retardation 5p and miR-484 had decreased expression in gestational protein-restricted left ventricle. +other 31034522 hsa-let-7g Fetal Growth Retardation 5p and miR-484 had decreased expression in gestational protein-restricted left ventricle. +other 31034522 hsa-mir-181a Fetal Growth Retardation 5p and miR-484 had decreased expression in gestational protein-restricted left ventricle. +other 31034522 hsa-mir-125a Fetal Growth Retardation 5p and miR-484 had decreased expression in gestational protein-restricted left ventricle. +other 31034522 hsa-mir-107 Fetal Growth Retardation 5p and miR-484 had decreased expression in gestational protein-restricted left ventricle. +transcription factor target 31034464 hsa-mir-29a Nasopharyngeal Carcinoma CONCLUSIONS miR-29a is a critical determinant of NPC radio-response for NPC patients, and its induction provides a promising therapeutic choice to elevate NPC radio-sensitivity. +genetics_overexpression_promote 31034165 hsa-mir-222 Colorectal Neoplasms Down-expression of MST3 in CRC cell lines enhanced their migration and invasion, but overexpression of MST3 could attenuate miR-222 overexpression in the promotion of migration and invasion in colorectal cell lines. +lncRNA target 31033484 hsa-mir-21 Heart Failure microRNA array and PCR analysis revealed dysregulation of miR +lncRNA target 31033463 hsa-mir-98 Retinoblastoma CONCLUSION: MiR-98 targets HMGA2 to act as a tumor suppressor in RB by mediating Wnt/beta-catenin pathway. +genetics_overexpression_promote 31033083 hsa-mir-641 Uterine Cervical Neoplasms These results demonstrated that overexpression of TUSC8 could inhibit the invasion and migration of CC cells by upregulating PTEN via miR-641. +genetics_overexpression_promote 31033015 hsa-mir-21 Triple Negative Breast Neoplasms LncRNA AWPPH overexpression led to upregulated miRNA-21 in TNBC cells, while miRNA-21 overexpression also led to significantly upregulated lncRNA AWPPH expression. +transcription factor target 31032951 hsa-mir-143 Colorectal Neoplasms miR-143 is a tumor suppressor miRNA which its downregulation is frequently reported in colorectal cancer (CRC). +other 31032663 hsa-mir-10b Colorectal Neoplasms We found that miR-10b expression was up-regulated in metastatic CRC tissues and cell lines. +lncRNA target 31032652 hsa-mir-34c Pulmonary Disease, Chronic Obstructive Conclusion: MiR-34c-5p may promote inflammation response and maintain the protease-antiprotease balance via targeting CCL22, which provides scientific basis for the clinical treatment of COPD. +other 31032588 hsa-mir-378e Adenocarcinoma of Lung Six prognostic-related miRNAs were screened by Cox survival analysis, namely hsa-mir-21, hsa-mir-142, hsa-mir-200a high expression, hsa-mir-101, hsa-let-7c, hsa-mir-378e low expression, hsa-mir-21 and hsa-mir-378e were associated with poor prognosis in patients with lung adenocarcinoma, and the survival time was shortened significantly (P<0.05, AUC=0.618). CONCLUSIONS: Hsa-mir-21 and hsa-mir-378e are associated with poor prognosis of lung adenocarcinoma, and may be used as a molecular marker for prognosis of lung adenocarcinoma after further clinical verification. +other 31032588 hsa-mir-21 Adenocarcinoma of Lung Six prognostic-related miRNAs were screened by Cox survival analysis, namely hsa-mir-21, hsa-mir-142, hsa-mir-200a high expression, hsa-mir-101, hsa-let-7c, hsa-mir-378e low expression, hsa-mir-21 and hsa-mir-378e were associated with poor prognosis in patients with lung adenocarcinoma, and the survival time was shortened significantly (P<0.05, AUC=0.618). CONCLUSIONS: Hsa-mir-21 and hsa-mir-378e are associated with poor prognosis of lung adenocarcinoma, and may be used as a molecular marker for prognosis of lung adenocarcinoma after further clinical verification. +other 31032345 hsa-mir-15b Glioma Increased expression of miR-15b (HR, 1.584; 95% CI, 1.199-2.092), 21 (HR, 1.591; 95% CI, 1.278-1.981), 148a (HR, 1.122; 95% CI, 1.023-1.231), 196 (HR, 1.877; 95% CI, 1.033-3.411), 210 (HR, 1.251; 95% CI, 1.010-1.550), and 221 (HR, 1.269; 95% CI, 1.054-1.527) or decreased expression of miR-106a (HR, 0.809; 95% CI, 0.655-0.998) and 124 (HR, 0.833; 95% CI, 0.729-0.952) was correlated with poor outcome of glioma patients. CONCLUSIONS: miR-15b, 21, 148a, 196, 210, 221, 106a, and 124 are valuable biomarkers for the prognosis of glioma which might be used in clinical settings. +other 31031866 hsa-mir-21 Stomach Neoplasms Results: The miRNAs hsa-miR-10a, -miR-21, -miR-135b, hsa-miR-148a, -miR-150, -miR-215, -miR-204, -miR-483 and -miR-664a were up-regulated in ADJ and GC compared to NC (P<0.03); and hsa-miR-21 and -miR-135b were up-regulated in GC compared to ADJ (P<0.01). Hsa-miR-148a, -miR-150, -miR-215, -miR-483 and -miR-664a were not differentially expressed between GC and ADJ, suggesting that both share similar changes (P>0.1). +other 31031866 hsa-mir-150 Stomach Neoplasms Results: The miRNAs hsa-miR-10a, -miR-21, -miR-135b, hsa-miR-148a, -miR-150, -miR-215, -miR-204, -miR-483 and -miR-664a were up-regulated in ADJ and GC compared to NC (P<0.03); and hsa-miR-21 and -miR-135b were up-regulated in GC compared to ADJ (P<0.01). Hsa-miR-148a, -miR-150, -miR-215, -miR-483 and -miR-664a were not differentially expressed between GC and ADJ, suggesting that both share similar changes (P>0.1). +other 31031866 hsa-mir-148a Stomach Neoplasms Results: The miRNAs hsa-miR-10a, -miR-21, -miR-135b, hsa-miR-148a, -miR-150, -miR-215, -miR-204, -miR-483 and -miR-664a were up-regulated in ADJ and GC compared to NC (P<0.03); and hsa-miR-21 and -miR-135b were up-regulated in GC compared to ADJ (P<0.01). Hsa-miR-148a, -miR-150, -miR-215, -miR-483 and -miR-664a were not differentially expressed between GC and ADJ, suggesting that both share similar changes (P>0.1). +other 31031866 hsa-mir-483 Stomach Neoplasms Results: The miRNAs hsa-miR-10a, -miR-21, -miR-135b, hsa-miR-148a, -miR-150, -miR-215, -miR-204, -miR-483 and -miR-664a were up-regulated in ADJ and GC compared to NC (P<0.03); and hsa-miR-21 and -miR-135b were up-regulated in GC compared to ADJ (P<0.01). Hsa-miR-148a, -miR-150, -miR-215, -miR-483 and -miR-664a were not differentially expressed between GC and ADJ, suggesting that both share similar changes (P>0.1). +other 31031848 hsa-mir-338 Carcinoma, Ovarian Epithelial 3p and up-regulation of MACC1 gene were closely related with the poor prognosis of epithelial ovarian cancer patients, which could served as bio-markers of the progression and recurrence of ovarian cancer. +other 31031831 hsa-mir-93 Instent Restenosis 5 p predicted CAD after adjustment for traditional CAD RFs. +genetics_knock down_promote 31031600 hsa-mir-134 Status Epilepticus Consistently, silencing miR-134 significantly diminished loss of CA3 pyramidal neurons using Nissl staining as well as reducing aberrant mossy fiber sprouting (MFS) in a rat epileptic model. +tissue_expression_ns 31031401 hsa-mir-140 Osteoporosis This study aimed to investigate the role of estrogen deficiency, selective modulation of expression of the estrogen receptor (ER), and expression of miR5p in cartilage and subchondral bone remodeling in an ovariectomized rat model of postmenopausal OA. +tissue_expression_ns 31031401 hsa-mir-140 Osteoporosis, Postmenopausal This study aimed to investigate the role of estrogen deficiency, selective modulation of expression of the estrogen receptor (ER), and expression of miR5p in cartilage and subchondral bone remodeling in an ovariectomized rat model of postmenopausal OA. +circulation_biomarker_diagnosis_up 31030498 hsa-mir-21 Breast Neoplasms Results: Expression of circulating miR-21 was significantly elevated in breast cancer patients compared to healthy women (median miR-21 expression levels were 7.67+/-2.2 and 1.28+/-0.16, respectively; p<0.0001). +genetics_GWAS 31030445 hsa-mir-146a Arthritis, Rheumatoid RESULTS: The distribution of SNPs of miR-146a rs2910164 among RA patients did not differ from that of the control group. +genetics_overexpression_promote 31030335 hsa-mir-211 Thyroid Cancer, Papillary 5p overexpression could reverse the promoting role of MCM3AP-AS1 in papillary thyroid cancer, whereby SPARC plays an important regulating role. +transcription factor target 31030195 hsa-mir-495 Hypertension, Pulmonary RESULTS: The inhibition of miR-495 improves hemodynamics and vascular remodeling in PH. +genetics_GWAS 31029881 hsa-mir-675 Dentin Dysplasia CONCLUSIONS: Our new findings, for the first time, suggest that MU-DLX3 significantly inhibits hDPCs differentiation via H19/miR-675 axis and provides a new mechanism insight into how MU-DLX3 epigenetically alters H19 methylation status and expression contributes to dentin hypoplasia in TDO syndrome. +genetics_GWAS 31029881 hsa-mir-675 Tricho-dento-osseous syndrome CONCLUSIONS: Our new findings, for the first time, suggest that MU-DLX3 significantly inhibits hDPCs differentiation via H19/miR-675 axis and provides a new mechanism insight into how MU-DLX3 epigenetically alters H19 methylation status and expression contributes to dentin hypoplasia in TDO syndrome. +genetics_GWAS 31029863 hsa-mir-199a Cardiovascular Diseases This is the first study to link miR-199a-5p expression with hypertension in a genetically at-risk cohort of premature CVD patients. +lncRNA target 31029744 hsa-mir-519a Carcinoma, Non-Small-Cell Lung In conclusion, Linc00221 promotes cisplatin resistance in NSCLC through the downstream miR-519a/ZBTB5 signaling axis, which could be used as a potential diagnostic and therapeutic target for clinical cisplatin-resistant NSCLC patients. +circulation_biomarker_diagnosis_up 31029709 hsa-mir-216a Angelman Syndrome Our data revealed that MALAT1 was upregulated and miR-216a-5p was downregulated in serum of AS patients and ox-LDL-treated HUVECs. In all, our data suggested that MALAT1 might play a protective role at least partly by sponging miR-216a-5p and regulating Beclin-1, highlighting that MALAT1 might be a potential therapeutic target of AS. +circulation_biomarker_diagnosis_ns 31029676 hsa-mir-144 Tuberculosis As a proof of concept, two fluorescence-labeled ssDNA tags were used for detection of miR-29a and miR-144*, two miRNAs that are highly expressed in the blood circulation of some patients with cancer or tuberculosis. +circulation_biomarker_diagnosis_ns 31029676 hsa-mir-29a Tuberculosis As a proof of concept, two fluorescence-labeled ssDNA tags were used for detection of miR-29a and miR-144*, two miRNAs that are highly expressed in the blood circulation of some patients with cancer or tuberculosis. +genetics_GWAS 31029648 hsa-mir-17 Multiple Myeloma CONCLUSION: Polymorphisms of MIR17HG rs7336610 and rs1428 were correlated with MM risk and prognosis. +other 31029604 hsa-mir-433 Uterine Cervical Neoplasms What's more, circ-ATP8A2 could promote cell progression by miR-433/EGFR axis in CC cells. +other 31029553 hsa-mir-29b Uterine Cervical Neoplasms These findings identify miR-29b as a radiosensitizing microRNA and reveal a new therapeutic strategy for radioresistant tumors. +genetics_overexpression_suppress 31029422 hsa-mir-7 Colorectal Neoplasms Moreover, overexpression of TRIP6 reduced miR-7 inhibitor-mediated CRC cell migration and invasion. +transcription factor target 31029421 hsa-mir-466 Cardiomegaly In the course of the study, we find that miR-466h-5p regulates the occurrence of myocardial hypertrophy via myocardin and it can upregulate the expression of myocardin through directly binding to the promoter region of myocardin. Thus, miR-466h-5p and myocardin form a positive regulation loop in the process of cardiac hypertrophy. +other 31029062 hsa-mir-20a Prostatic Neoplasms For example, we find multiple known (e.g., miR-20a-PTEN-PTENP1) and novel (e.g., miRSOX15-PPP4R1L) microRNA-gene-pseudogene associations in prostate cancer. +other 31029057 hsa-mir-222 Alzheimer Disease Of the four miRNAs analyzed, miR-222 levels were significantly increased in VD patients compared to both CNS and AD. In addition, while NF-light showed a better diagnostic performance than miR-222 and classical AD biomarkers in differentiating TP and VD from CNS, classical AD biomarkers revealed higher performance in discriminating AD from non-AD disorders.Overall, our results suggest that CSF NF-light and miR-222 are promising biomarkers that may help to diagnose non-AD disorders. +other 31029057 hsa-mir-125b Alzheimer Disease One hundred fifty-three patients were recruited and tested for classical AD CSF biomarkers- Amyloid-ss42 and tau proteins - and novel candidate biomarkers - neurofilament (NF-) light and microRNA (miR) -21, -125b, -146a, and -222.All dementia patients had significantly higher concentrations of NF-light compared to CNS, with the TP group displaying the highest NF-light values. +other 31029057 hsa-mir-146a Alzheimer Disease One hundred fifty-three patients were recruited and tested for classical AD CSF biomarkers- Amyloid-ss42 and tau proteins - and novel candidate biomarkers - neurofilament (NF-) light and microRNA (miR) -21, -125b, -146a, and -222.All dementia patients had significantly higher concentrations of NF-light compared to CNS, with the TP group displaying the highest NF-light values. +other 31029057 hsa-mir-21 Alzheimer Disease One hundred fifty-three patients were recruited and tested for classical AD CSF biomarkers- Amyloid-ss42 and tau proteins - and novel candidate biomarkers - neurofilament (NF-) light and microRNA (miR) -21, -125b, -146a, and -222.All dementia patients had significantly higher concentrations of NF-light compared to CNS, with the TP group displaying the highest NF-light values. +transcription factor target 31028887 hsa-mir-34a Breast Neoplasms Finally, miR-34a delivery through intra-tumor administration of SiO(2)NPs leads to a reduced mammary tumor growth. In conclusion, our studies suggest that silica nanoparticles can mediate the delivery of miR-34a directly into mammary tumors while preserving its molecular and biological activity. +lncRNA target 31028805 hsa-mir-1202 Anemia, Aplastic Microarray based miRNA expression profiling (GSE82095) also identified that miR-1202 was significantly upregulated among aplastic anaemia patients compared to controls and can potentially target RAPGEF5 and MANEA genes based on target prediction of miRNAs. +genetics_overexpression_promote 31028536 hsa-mir-1291 Carcinoma, Hepatocellular We propose that GPC3 overexpression and its associated oncogenic effects are linked to the upregulation of miR-1291 in HCV patients. +genetics_overexpression_promote 31028536 hsa-mir-1291 Liver Cirrhosis We propose that GPC3 overexpression and its associated oncogenic effects are linked to the upregulation of miR-1291 in HCV patients. +other 31028191 hsa-mir-363 Aortic Aneurysm, Abdominal 3p. +genetics_GWAS 31028134 hsa-let-7 Breast Neoplasms We examined two SNPs rs10877887 and rs13293512 in the promoters of let-7 family to determine if the two SNPs were related to the occurrence of breast cancer (BC). These findings suggest that rs13293512 in the promoter of let-7a-1/let-7f-1/let-7d cluster may be a possible biomarker for the development of BC in Chinese women. +genetics_GWAS 31028134 hsa-let-7f-1 Breast Neoplasms We examined two SNPs rs10877887 and rs13293512 in the promoters of let-7 family to determine if the two SNPs were related to the occurrence of breast cancer (BC). These findings suggest that rs13293512 in the promoter of let-7a-1/let-7f-1/let-7d cluster may be a possible biomarker for the development of BC in Chinese women. +lncRNA target 31028132 hsa-mir-550a Esophageal Squamous Cell Carcinoma These results suggest that miR-550a may serve as a therapeutic target and predictor for ESCA survival. +other 31027524 hsa-mir-21 Lung Neoplasms As a proof of concept, the proposed methodology is validated using two biomarkers; lung cancer associated microRNA (mir21) and hepatitis B virus DNA (HBV-DNA). +other 31026664 hsa-mir-212 Cocaine-Related Disorders Based on translational and clinical findings, we compared the expression levels of microRNA-124 (miR-124), microRNA-181 (miR-181), and microRNA-212 (miR-212) between a group of females with cocaine use disorder (CUD; n=30) and a group of healthy female controls (HC; n=20). +circulation_biomarker_diagnosis_up 31026664 hsa-mir-181 Cocaine-Related Disorders CONCLUSIONS MiR-124 and miR-181 show promise as biomarkers for CUD when assessed in the peripheral blood. +other 31026664 hsa-mir-124 Cocaine-Related Disorders Based on translational and clinical findings, we compared the expression levels of microRNA-124 (miR-124), microRNA-181 (miR-181), and microRNA-212 (miR-212) between a group of females with cocaine use disorder (CUD; n=30) and a group of healthy female controls (HC; n=20). +lncRNA target 31026569 hsa-mir-412 Hemorrhoids 5p expression in hemorrhoid vascular endothelial cells leads to high expression of the target gene Xpo1 and translocation of the p53 protein out of the nucleus, rendering it unable to activate p66(SHC) and p16. +circulation_biomarker_diagnosis_up 31026554 hsa-mir-122 Liver Injury RESULTS: Hepatotoxicity in male rats with moderate inflammation induced by XLGB was indicated by liver histopathology, serum biochemical analysis, serum miR-122 levels, and immunofluorescent assessments. Similarly, miR-122 was significantly elevated in XLGB/LPS treated rats relative to other groups. +transcription factor target 31026342 hsa-mir-200a Mouth Neoplasms Forced expression of miR-200b/a/429 inhibited expression of ZEB1/2 and decreased cell migration in OSCC cell lines CAL27 and HSC3. +lncRNA target 31026342 hsa-mir-200 Squamous Cell Carcinoma of Head and Neck We predicted that miR-200a and miR-200b could recognize QKI 3'-UTR by analyzing TargetScan and The Cancer Genome Atlas head and neck squamous cell carcinoma (HNSCC) dataset. +lncRNA target 31026342 hsa-mir-200a Squamous Cell Carcinoma of Head and Neck We predicted that miR-200a and miR-200b could recognize QKI 3'-UTR by analyzing TargetScan and The Cancer Genome Atlas head and neck squamous cell carcinoma (HNSCC) dataset. +other 31026342 hsa-mir-200 Neoplasms, Glandular and Epithelial The microRNA-200 (miR-200) family plays a major role in specifying epithelial phenotype by preventing expression of the transcription repressors ZEB1 and ZEB2, which are well-known regulators of the epithelial-to-mesenchymal transition (EMT) in epithelial tumors including oral squamous cell carcinoma (OSCC). +transcription factor target 31026342 hsa-mir-429 Mouth Neoplasms Forced expression of miR-200b/a/429 inhibited expression of ZEB1/2 and decreased cell migration in OSCC cell lines CAL27 and HSC3. +lncRNA target 31026342 hsa-mir-200 Mouth Neoplasms The microRNA-200 (miR-200) family plays a major role in specifying epithelial phenotype by preventing expression of the transcription repressors ZEB1 and ZEB2, which are well-known regulators of the epithelial-to-mesenchymal transition (EMT) in epithelial tumors including oral squamous cell carcinoma (OSCC). Forced expression of miR-200b/a/429 inhibited expression of ZEB1/2 and decreased cell migration in OSCC cell lines CAL27 and HSC3. +transcription factor target 31026342 hsa-mir-200b Mouth Neoplasms Forced expression of miR-200b/a/429 inhibited expression of ZEB1/2 and decreased cell migration in OSCC cell lines CAL27 and HSC3. +lncRNA target 31026342 hsa-mir-200b Squamous Cell Carcinoma of Head and Neck We predicted that miR-200a and miR-200b could recognize QKI 3'-UTR by analyzing TargetScan and The Cancer Genome Atlas head and neck squamous cell carcinoma (HNSCC) dataset. +circulation_biomarker_diagnosis_ns 31026335 hsa-mir-141 Pre-Eclampsia In the peripheral blood and placenta of preeclamptic patients, EG-VEGF showed significantly lower expression, whereas plasma miR-141 and miR-200a had higher expression compared with the controls. +circulation_biomarker_diagnosis_ns 31026335 hsa-mir-200a Pre-Eclampsia In the peripheral blood and placenta of preeclamptic patients, EG-VEGF showed significantly lower expression, whereas plasma miR-141 and miR-200a had higher expression compared with the controls. +transcription factor target 31025335 hsa-mir-15b Norrie disease Altogether, these findings manifested that miR-15b-5p protectively antagonized HG-triggered podocyte damage through relieving HG-induced apoptosis, oxidative stress, and inflammatory process in podocytes by targeting Sema3A, suggesting that miR-15b-5p might be a new therapeutic agent to improve management of DN. +transcription factor target 31025251 hsa-mir-363 Osteoporosis 3p regulates osteoporosis pathogenesis via PTEN/PI3K/AKT signaling pathway. +transcription factor target 31024564 hsa-mir-135 Allergic Inflammation 5p mimic also inhibited cellular interactions during allergic inflammation. +lncRNA target 31024042 hsa-mir-135b Breast Neoplasms For the functional study, the inhibition of miR-135b-5p was accompanied by increased BC cell growth, epithelial-mesenchymal transition (EMT), migration and invasion in vitro. +circulation_biomarker_diagnosis_ns 31023966 hsa-mir-133a Osteoporosis, Postmenopausal In this meta-analysis, it is stated that circulating hsa-miR-133a-3p may serve as a potential non-invasive biomarker and therapeutic target in PMO. +lncRNA target 31023531 hsa-mir-205 Uterine Cervical Neoplasms Conclusively, we found that MIR205HG was upregulated in cervical cancer tissues supported by GEPIA database and in cell lines through qRT-PCR, and its depletion inhibited the proliferation and metastasis of CC cells. +lncRNA target 31023531 hsa-mir-122 Uterine Cervical Neoplasms Conclusively, these results demonstrated that MIR205HG could serve as a ceRNA in CC progression by modulating miR5p/FOXP2 axis and exert a pro-tumorigenesis function, which may be a novel therapeutic target for diagnosis and the treatment of CC. +circRNA target 31023528 hsa-mir-141 Endometriosis Downregulated circular RNA hsa_circ_0067301 regulates epithelial-mesenchymal transition in endometriosis via the miR-141/Notch signaling pathway. +other 31023029 hsa-mir-34c Uterine Cervical Neoplasms CONCLUSION: Comparative expression analysis revealed lower expression of miR-34c in cervical precanceroses than in normal untransformed epithelium. Key words: cervical cancer - HPV - miRNA - HSIL - hsa-miR-34c - precancerosis This work was supported by the projects MEYS - NPS I - LO1413, P206/12/G151 and MH CZ - DRO (MMCI, 00209805). +circulation_biomarker_diagnosis_down 31022636 hsa-mir-145 Epilepsy 5p in plasma was downregulated significantly in the patients with refractory epilepsy (1.1801.036 vs. +lncRNA target 31022596 hsa-mir-142 Arthritis, Rheumatoid The anti-RA potential of Sal-B might be via up-regulating miR3p, and subsequently modulating NF-kappaB and JNK pathways. +other 31022558 hsa-mir-130a Aortic Aneurysm, Thoracic We identified that let-7 g (0.71-fold, p = 0.01), miR-130a (0.40-fold, p = 0.04), and miR-221 (0.49-fold, p = 0.05) significantly differed between TAA patients and healthy controls. +other 31022558 hsa-mir-221 Aortic Aneurysm, Thoracic We identified that let-7 g (0.71-fold, p = 0.01), miR-130a (0.40-fold, p = 0.04), and miR-221 (0.49-fold, p = 0.05) significantly differed between TAA patients and healthy controls. +other 31022558 hsa-let-7g Aortic Aneurysm, Thoracic We identified that let-7 g (0.71-fold, p = 0.01), miR-130a (0.40-fold, p = 0.04), and miR-221 (0.49-fold, p = 0.05) significantly differed between TAA patients and healthy controls. +lncRNA target 31022384 hsa-mir-539 Pancreatic Carcinoma In conclusion, the results of the current study present evidence emphasizing the significance of the interactions between miR-539 and TWIST1 in the development of and progression of PC, highlighting its potential as a therapeutic target in the treatment of PC patients. +other 31021476 hsa-mir-584 Periodontitis Moreover, circ_0062491 was identified as the sponge of miR-584 which play a key role in periodontitis. +other 31021403 hsa-mir-143 Chronic Periodontitis Also, the results of the study points to the potential utility of miR143-3p as a novel salivary biomarker for chronic periodontitis. +other 31021403 hsa-mir-143 Periodontitis Also, the results of the study points to the potential utility of miR143-3p as a novel salivary biomarker for chronic periodontitis. +genetics_overexpression_promote 31021172 hsa-mir-182 Carcinoma, Hepatocellular 5p, which highlights overexpression of LINC01018 as a candidate suppressor of HCC.NEW & NOTEWORTHY This study provides evidence for understanding the molecular mechanism involved in the progression of hepatocellular carcinoma and identifies a novel network of LINC01018/miR +lncRNA target 31020761 hsa-mir-205b Melanoma We previously reported that chemically modified synthetic miRNA-205 (miR-205BP/S3) inhibits melanoma growth in vitro and in vivo. The present results suggest that intratumoral administration of miR-205BP/S3 is a potentially applicable treatment for canine melanoma. +other 31020693 hsa-mir-1236 Glioma Collectively, circ_001350 directly sponges miR-1236, thus contributing to malignant progression of glioma. +lncRNA target 31020662 hsa-mir-23a Asthma Thus, miR-23a may present a potential new target for the therapy of asthma. +lncRNA target 31020657 hsa-mir-192 Colorectal Neoplasms Based on results derived from multiple approaches, we identified the biological functions of miR-192/215-5p as a tumor suppressor and link Crohn's disease and colorectal cancer by targeting triglyceride synthesis and extracellular matrix remodeling pathways. +lncRNA target 31020657 hsa-mir-215 Colorectal Neoplasms Based on results derived from multiple approaches, we identified the biological functions of miR-192/215-5p as a tumor suppressor and link Crohn's disease and colorectal cancer by targeting triglyceride synthesis and extracellular matrix remodeling pathways. +lncRNA target 31020657 hsa-mir-215 Crohn Disease Based on results derived from multiple approaches, we identified the biological functions of miR-192/215-5p as a tumor suppressor and link Crohn's disease and colorectal cancer by targeting triglyceride synthesis and extracellular matrix remodeling pathways. +lncRNA target 31020657 hsa-mir-192 Crohn Disease Based on results derived from multiple approaches, we identified the biological functions of miR-192/215-5p as a tumor suppressor and link Crohn's disease and colorectal cancer by targeting triglyceride synthesis and extracellular matrix remodeling pathways. +lncRNA target 31020570 hsa-mir-24-2 Esophageal Squamous Cell Carcinoma 2 have been reported to be dysregulated in various cancers and contribute in tumorigenesis and progression; thus, evaluating their expressional behavior and its association with tumor states alteration in ESCC could potentially be helpful. +lncRNA target 31020570 hsa-mir-27a Esophageal Squamous Cell Carcinoma 2 have been reported to be dysregulated in various cancers and contribute in tumorigenesis and progression; thus, evaluating their expressional behavior and its association with tumor states alteration in ESCC could potentially be helpful. +transcription factor target 31020472 hsa-mir-3 Scholte syndrome Here, we confirmed that miR-33 could target the 3'UTR of insulin-induced gene 1 (insig1), resulting in downregulation of its protein level in the rabbitfish hepatocyte line (SCHL). +genetics_knock down_promote 31019537 hsa-mir-613 Arthritis, Rheumatoid Overexpression of miR-613 or knockdown of DKK1 suppressed proliferation and invasion of RASFs, and induced RASF apoptosis. +lncRNA target 31018949 hsa-mir-199b Carcinoma, Renal Cell In addition, we validated DDR1 as a target gene for miR-199a/b-5p in renal cancer cell lines. +lncRNA target 31018949 hsa-mir-199a Carcinoma, Renal Cell In addition, we validated DDR1 as a target gene for miR-199a/b-5p in renal cancer cell lines. +transcription factor target 31018918 hsa-mir-3162 Prostatic Neoplasms 5p and its interactive axis as a new class of biomarkers and therapeutic targets for PCa. +other 31018714 hsa-mir-126 Respiration Disorders The study aimed at investigating the expression levels of mir-126 and mir-124, as well as TNF- as possible biomarkers of expected smoking-related diseases. Conclusions: MiR-126 and TNF- are potential biomarkers of smoking-related diseases and are important in assessing the expected tobacco-related harm. +other 31018714 hsa-mir-124 Respiration Disorders The study aimed at investigating the expression levels of mir-126 and mir-124, as well as TNF- as possible biomarkers of expected smoking-related diseases. +transcription factor target 31018621 hsa-mir-155 Leukemia, Lymphocytic, Chronic, B-Cell Here we show that the heterogeneous nuclear ribonucleoprotein L (HNRNPL) binds to the polymorphic marker D2S1888 at the 3'UTR of BUB1 gene, impairs the miR-155 targeting, and restores BUB1 expression in chronic lymphocytic leukemia. +lncRNA target 31018244 hsa-mir-16-2 Osteosarcoma Using RNA immunoprecipitation (RIP) assays, we identify direct targets of miR +lncRNA target 31018244 hsa-mir-16-1 Osteosarcoma Using RNA immunoprecipitation (RIP) assays, we identify direct targets of miR +transcription factor target 31018114 hsa-mir-200c Epilepsy OBJECTIVE: The aim of this study is to investigate the role of mircoRNA-200c-3p (miR-200c-3p) on hippocampal neuron injury in epileptic rats through the regulation of the AKT signaling pathway by targeting RECK. +lncRNA target 31018104 hsa-mir-628 Osteosarcoma 5p promoted the growth and motility of OS at least partly by targeting IFI44L. +other 31018043 hsa-mir-146a Hepatitis B, Chronic miR-146a-5p was highly expressed in patients with chronic hepatitis B (CHB) and HBV-expressing hepatocytes. +other 31018043 hsa-mir-146a Hepatitis B miR-146a-5p was highly expressed in patients with chronic hepatitis B (CHB) and HBV-expressing hepatocytes. +lncRNA target 31017720 hsa-mir-144 Uterine Cervical Neoplasms Taken together, miR-144 overcomes resistance to CDDP via promoting cell apoptosis and inhibiting invasion through targeting LHX2 in cervical cancer cells. +other 31017716 hsa-mir-374a Esophageal Squamous Cell Carcinoma To sum up, we demonstrated that LINC00473 facilitated radioresistance by regulating the miR-374a-5p/SPIN1 axis in ESCC. +lncRNA target 31017699 hsa-mir-1 Esophageal Squamous Cell Carcinoma Taken together, the present results suggest that miR-1 may be a valuable prognostic predictor for ESCC, and the miR-1/FN1 axis may be a therapeutic target. +other 31017694 hsa-mir-1225 Neoplasms, Multiple Primary SIGNIFICANCE OF THE STUDY: Our study showed that miR-1225 is significant in multiple malignancies and other pathological reactions. +other 31017674 hsa-mir-542 COVID-19 3p and TNFRSF21, which may contribute to neuroinflammation during CHPV infection in human microglial cells. +other 31017674 hsa-mir-92a-1 COVID-19 3p and TNFRSF21, which may contribute to neuroinflammation during CHPV infection in human microglial cells. +other 31017674 hsa-mir-187 COVID-19 3p and TNFRSF21, which may contribute to neuroinflammation during CHPV infection in human microglial cells. +lncRNA target 31017473 hsa-mir-21 Stomach Neoplasms Thus, a combination of anti-miR21 and RSV in a targeted nanocarrier might be a promising drug delivery system for gastric cancer therapy. +genetics_GWAS 31017268 hsa-mir-193a Breast Neoplasms Overexpression of miR193a3p could inhibit proliferation, migration and invasion of breast cancer cells. +transcription factor target 31017266 hsa-mir-576 Glioma In conclusion, the present study confirms that miR5763p is a novel GBM inhibitor and its inhibition of the migration and proangiogenic capacity of hypoxiainduced glioma cells is mediated by HIF1. +other 31016944 hsa-mir-155 Carcinoma, Renal Cell Further survival analysis revealed that 38 lncRNAs (including COL18A1-AS1, TCL6, LINC00475, UCA1, WT1-AS, HOTTIP, PVT1, etc.) and 2 miRNAs (including miR-21 and miR-155) were correlated with the overall survival time of CCRCC ( P < 0.05). +other 31016944 hsa-mir-21 Carcinoma, Renal Cell Further survival analysis revealed that 38 lncRNAs (including COL18A1-AS1, TCL6, LINC00475, UCA1, WT1-AS, HOTTIP, PVT1, etc.) and 2 miRNAs (including miR-21 and miR-155) were correlated with the overall survival time of CCRCC ( P < 0.05). +lncRNA target 31016902 hsa-mir-362 Colorectal Neoplasms CONCLUSION: miR-362 may be a prognostic marker in CRC and suppress CRC cell proliferation and invasion in part through targeting the 3'-UTR of SIX1 mRNA. +transcription factor target 31016850 hsa-mir-449c Pituitary ACTH Hypersecretion Low expression of lncTHBS1, along with low expression of TSP-1, was associated with the high expression of miR-449c in Cushing's disease patients. Taken together, this study has demonstrated that lncTHBS1 might function as competing endogenous RNA for miR-449c, which could suppress the development of Cushing's disease. +circulation_biomarker_diagnosis_up 31016789 hsa-mir-544a Coronary Artery Disease In plasma and tissue of patients with coronary artery atherosclerosis, LEF1-AS1 was upregulated and miR-544a was downregulated. +circulation_biomarker_diagnosis_ns 31016755 hsa-mir-125a Sleep Deprivation In summary, chronic short sleep is associated with a marked reduction in circulating levels of miR-125a, miR-126 and miR-146a. +circulation_biomarker_diagnosis_ns 31016755 hsa-mir-126 Sleep Deprivation In summary, chronic short sleep is associated with a marked reduction in circulating levels of miR-125a, miR-126 and miR-146a. +circulation_biomarker_diagnosis_ns 31016755 hsa-mir-146a Sleep Deprivation In summary, chronic short sleep is associated with a marked reduction in circulating levels of miR-125a, miR-126 and miR-146a. +genetics_overexpression_promote 31016725 hsa-mir-203 Melanoma In conclusion, our results clearly determined that miR-203 could be down-regulateddownregulated in melanoma tissues but be overexpressed in melanoma stem cells. +lncRNA target 31016687 hsa-mir-155 Neuralgia In results, intrathecal administration of miR-155 inhibitor attenuated mechanical allodynia and cold hyperalgesia in rats with OXL therapy and this was accompanied with restoring of impaired Nrf2-ARE in the dorsal horn. +lncRNA target 31016619 hsa-mir-144 Uterine Cervical Neoplasms 3p as a tumor suppressive miRNA in cervical cancer. +other 31016187 hsa-mir-140 Cartilage Diseases The aim of the present study was to investigate the effects of phosphorylatable nucleus localization signal linked nucleic kinase substrate short peptide ((p)NNS)-conjugated chitosan ((p)NNS-CS) mediated miR-140 and IGF-1 in both rabbit chondrocytes and cartilage defects model. This study indicate that (p)NNS-CS is a better gene delivery vehicle in gene therapy for cartilage defects and that miR-140 combination IGF-1 transfection has better biologic effects on cartilage defects. +circulation_biomarker_diagnosis_up 31016114 hsa-mir-155 Macrophage Activation Syndrome In this study, a functional nanomaterial, layered double hydroxides (LDHs), carrying specific functional miR155 is developed to modulate ITM by synergistically repolarizing tumor associated macrophages (TAMs) to M1 subtype. LDH nanoparticles loaded with miR155 (LDH@155) exhibit superior ability in cellular uptake by murine macrophages, miR escape into the cytoplasm and TAMs specific delivery when introtumoral administration. +genetics_knock down_promote 31016032 hsa-mir-4521 Carcinoma, Renal Cell Both the FAM129A knockdown and miR-4521 overexpression could reduce the in vitro migration and invasion abilities of renal cancer cells 786-O and ACHN, through the TIMP-1/MMP2/MMP9 pathway and could decrease their proliferation by promoting their apoptosis through the MDM2/p53/Bcl2/Bax pathway. +other 31015570 hsa-mir-143 Cardiomegaly In the present study, we investigated whether AS-1 had attenuating effects on hypertension-induced cardiac hypertrophy, and whether this process was mediated by the regulation of miRNA-143. +lncRNA target 31015415 hsa-mir-25 Pancreatic Carcinoma 3p excessive maturation via m(6)A modification promotes the development and progression of pancreatic cancer. +circulation_biomarker_prognosis_ns 31015372 hsa-mir-19a Osteosarcoma The relation of miR-19a expression to OS was further recognized by fixed model within the studies of sample size less than 150 (HRs = 1.68, CI: 1.35-2.08), NOS scores greater than or equal to 8 (HRs = 1.53, CI: 1.13-2.06) or less than 8 (HRs = 1.89, CI: 1.58-2.27), specimen derived from tumor (HRs = 1.73, CI: 1.42-2.12) or blood (HRs = 1.87, CI: 1.46-2.40) and the patients of osteosarcoma (HRs = 7.17, CI: 5.04-10.21). Summarily, the over expression of miR-19a was an underlying risk of poor prognosis in many human malignancies, especially in osteosarcoma. +circulation_biomarker_diagnosis_ns 31015372 hsa-mir-19a Opitz GBBB Syndrome, X-Linked As a result, in overall analysis, a significant association was identified between miR-19a levels and OS (HRs = 2.31, CI: 1.11-4.83). The relation of miR-19a expression to OS was further recognized by fixed model within the studies of sample size less than 150 (HRs = 1.68, CI: 1.35-2.08), NOS scores greater than or equal to 8 (HRs = 1.53, CI: 1.13-2.06) or less than 8 (HRs = 1.89, CI: 1.58-2.27), specimen derived from tumor (HRs = 1.73, CI: 1.42-2.12) or blood (HRs = 1.87, CI: 1.46-2.40) and the patients of osteosarcoma (HRs = 7.17, CI: 5.04-10.21). +genetics_overexpression_promote 31015368 hsa-mir-139 Retinoblastoma 3p TP73-AS1 overexpression caused promoted proliferation of Rb cells but showed no significant effects on cell migration and invasion. +transcription factor target 31015365 hsa-mir-542 Glioma In addition, we observed that low-dose pristimerin inhibited the viability of glioma cells, while miR +other 31015361 hsa-mir-235 Aicardi-Goutieres syndrome 5 Consistent with the developmental roles of the Wnt pathway, the mir-235 interferes with its activity at the onset of adulthood, and not at the embryo stage, therefore protecting the embryo from putative developmental defects due to precocious inactivation of the Wnt pathway 1. +lncRNA target 31015341 hsa-mir-135a Epilepsy Mef2a and miR-135a show reciprocal expression regulation in human (of both sexes) and experimental TLE, and miR-135a regulates dendritic spine number and type through Mef2. +lncRNA target 31015227 hsa-mir-92 Melanoma Using The Cancer Genome Atlas database of patients with melanoma, we also noted a positive correlation between integrin alpha(5) and TGFbeta1 expression levels and an inverse association between miR-92 expression and integrin alpha subunit expression. SIGNIFICANCE: CD133(+) cells play an active role in suppressing melanoma antitumor immunity by modulating miR-92, which increases influx of immunosuppressive cells and TGFbeta1 expression. +lncRNA target 31014918 hsa-mir-125a Inflammatory Bowel Diseases Thus, our data suggest that miR-125a protects intestinal mucosa from inflammatory injury and that ETS-1 as its target participates in the pathogenesis of IBD. +genetics_knock down_promote 31014673 hsa-mir-29 Fibrosis Of interest, the loss of KDM4 was mirrored by the repression of miR-29, an antagonist of liver fibrosis, during HSC activation both in vitro and in vivo. +genetics_overexpression_promote 31014672 hsa-mir-619 spondyloepimetaphyseal dysplasia, Strudwick type 5p overexpression significantly attenuated the LINC00882-induced promotion effect on PDGF-induced cell proliferation and Wnt/beta-catenin signaling in fetal ASM cells. +lncRNA target 31014672 hsa-mir-619 Asthma Taken together, our results demonstrate that LINC00882 promotes PDGF-induced cell proliferation of ASM cells by enhancing Wnt/beta-catenin signaling via sponging miR5p, suggesting a potential role for LINC00882 in airway remodeling in pediatric asthma. +other 31014670 hsa-mir-411 Ovarian Neoplasms 3p contributing to carcinogenesis in OC. +lncRNA target 31014553 hsa-mir-145 Esophageal Squamous Cell Carcinoma BACKGROUND: MicroRNA-145 (miR-145) is commonly down-regulated and has been identified as a tumor-suppressive miRNA in multiple types of cancers, as well as in esophageal squamous cell carcinoma (ESCC). +circulation_biomarker_diagnosis_up 31014439 hsa-mir-34b Carcinoma, Non-Small-Cell Lung METHODS: The levels of miR-34b-3p and miR-302a-5p in plasma were detected by real-time polymerase chain reaction (RT-PCR) in 86 patients with NSCLC, 64 patients with pulmonary tuberculosis (PTB) and 39 healthy subjects. RESULTS: The levels of plasma miR-34b-3p and miR-302a-5p in NSCLC group were significantly higher than those in the PTB group and the healthy group (P<0.05). +genetics_knock down_promote 31014193 hsa-mir-124 Alzheimer Disease Knockdown of NEAT1 or overexpression of miR-124 showed the protective effects on cellular AD model induced by Abeta. +lncRNA target 31014175 hsa-mir-34a Sjogren's Syndrome Further, we found that PPP1R11 helped to inhibit apoptosis of PAM cells under SS2 infecting, through transcription factor AREB6 was negatively correlated with apoptosis whereas miR-34a was positively correlated. Those findings provide a functional connection among the transcription factor AREB6, miR-34a, PPP1R11 gene and apoptosis of PAM cells in the pathogenesis of the SS2 infection. +lncRNA target 31013711 hsa-mir-590 Ovarian Neoplasms 3p promotes ovarian cancer development, in part by directly targeting CCNG2 and FOXO3. +other 31013606 hsa-mir-452 Severe Acute Respiratory Syndrome These results indicate that IH stress down-regulates the miR-452 in adipocytes, resulting in increased levels of RETN, TNFalpha, and CCL2 mRNAs, leading to insulin resistance in SAS patients. +lncRNA target 31013436 hsa-mir-34a Pancreatic Carcinoma The results from the luciferase reporter assays confirmed that miR-34a directly targets XIST and suggested that XIST regulates cell proliferation, invasiveness, and apoptosis in PC by sponging miR-34a. +genetics_knock down_promote 31013434 hsa-let-7i Colorectal Neoplasms Moreover, gain-of-function studies of HOXA11-AS or loss-of-function studies of let-7i also revealed a negative correlation between HOXA11-AS and let-7i in propofol-mediated biological functions of CRC cells. We investigate the theory that propofol suppresses colorectal cancer tumorigenesis by modulating the HOXA11-AS-let-7i-ABCC10 regulatory network, indicating the potential for propofol to control CRC development. +circulation_biomarker_diagnosis_ns 31013225 hsa-mir-155 Atrial Fibrillation CONCLUSIONS: Our findings revealed that plasma miRNA-155 can present an ability to calculate AF recurrence after cardioversion. +lncRNA target 31012516 hsa-mir-34a Glioma In glioma cells, cell proliferation was inhibited by microRNA-34a. +other 31012177 hsa-mir-567 Adenocarcinoma of Lung These results suggested that cMras/miR-567/PTPRG regulatory pathway might be associated to LUAD tumorigenesis and development. CONCLUSIONS: A novel circular RNA cMras and its functions were identified, discovering a cMras/miR-567/PTPRG regulatory pathway in LUAD tumorigenesis and development. +genetics_overexpression_promote 31012127 hsa-mir-888 Asthenozoospermia 3p significantly overexpressed in AZS cases (p = 0.014) in comparison with controls. +other 31012108 hsa-mir-20b Colorectal Neoplasms Our findings indicated that the expression of miR-20b-5p is negatively correlated with that of metastasis-associated lung adenocarcinoma transcript-1 (MALAT1, r = -0.928, p = 0.023) and Oct4 (r = -0.894, p = 0.041) in CRC cells. +other 31011489 hsa-mir-181b Stroke Additional aging-related articles highlighted the involvement of miR-181b-5p and high mobility group box-1 in hypertension, Yes-associated protein in cataract formation, multiple miRs and long noncoding RNAs in coronary artery disease development, the role of higher meat consumption on sleep problems, and the link between glycated hemoglobin and depression. +other 31011489 hsa-mir-181b Alzheimer Disease Additional aging-related articles highlighted the involvement of miR-181b-5p and high mobility group box-1 in hypertension, Yes-associated protein in cataract formation, multiple miRs and long noncoding RNAs in coronary artery disease development, the role of higher meat consumption on sleep problems, and the link between glycated hemoglobin and depression. +other 31011489 hsa-mir-181b Amyotrophic Lateral Sclerosis Additional aging-related articles highlighted the involvement of miR-181b-5p and high mobility group box-1 in hypertension, Yes-associated protein in cataract formation, multiple miRs and long noncoding RNAs in coronary artery disease development, the role of higher meat consumption on sleep problems, and the link between glycated hemoglobin and depression. +circulation_biomarker_diagnosis_down 31011475 hsa-mir-181b Hypertension Our findings also highlight that the plasma levels of miR-181b-5p and HMGB1 may serve as novel biomarkers for vascular remodeling in the hypertensive patients. +transcription factor target 31011336 hsa-mir-29b Myocardial Infarction Targeting TRAF5 with miR-29b-3p might be a potential therapeutic method for AMI. +circulation_biomarker_diagnosis_ns 31010436 hsa-mir-933 arteriosclerotic cardiovascular disease The area under the curve (AUC) of miRNA-933 in distinguishing the hyperlipidemia and ASCVD patients was 0.739 (95% CI, 0.682-0.795; P < 0.01) and 0.703 (95% CI, 0.643-0.763, P < 0.01), respectively. Circulating miRNA-933 could be a feasible predictor for ASCVD at the early stage. +circulation_biomarker_diagnosis_ns 31010436 hsa-mir-933 Hyperlipidemias The area under the curve (AUC) of miRNA-933 in distinguishing the hyperlipidemia and ASCVD patients was 0.739 (95% CI, 0.682-0.795; P < 0.01) and 0.703 (95% CI, 0.643-0.763, P < 0.01), respectively. Circulating miRNA-933 could be a feasible predictor for ASCVD at the early stage. +lncRNA target 31010333 hsa-mir-208a Carcinoma, Non-Small-Cell Lung We also indicated that LINC-PINT mediated inhibitory effect on cell proliferation, cell cycle, cell migration and invasion by miR-208a-3p/programmed cell death 4 (PDCD4) in NSCLC cells. These findings indicated that LINC-PINT functions as a tumour-suppressor that exerts important regulatory roles in NSCLC progression by sponging miR-208a-3p/PDCD4. +other 31010087 hsa-mir-150 Squamous Cell Carcinoma of Head and Neck The expression of ZFAS1 and miR5p is negatively correlated in HNSCC patients. +other 31009917 hsa-mir-125b Multiple Myeloma Moreover, we identified a pattern of miR-125b-co-regulated miRNAs, shedding light on possible new players of anti-MM activity. +genetics_knock down_promote 31009837 hsa-mir-146a Endometrial Hyperplasia Furthermore, overexpression of miR-146a promoted and knockdown of miR-146a reduced Ang II-induced VSMC proliferation and ameliorated intimal hyperplasia induced by carotid artery ligation. CONCLUSION: Sal B inhibited Ang II-induced VSMC proliferation in vitro and intimal hyperplasia in vivo by downregulating miR-146a expression. +transcription factor target 31009516 hsa-mir-770 Breast Neoplasms Thus, regulating the expression level of miR5p in combination with trastuzumab treatment may simultaneously inhibit the downstream elements of PI3K and MAPK signalling, thereby blocking the proliferation, motility and invasion capacities of HER2+ breast cancer cells. +other 31009404 hsa-mir-21 Pancreatic Carcinoma 5p showed the highest discriminating capacity for pancreatic neoplasia (PDAC or IPMN) with an area under the receiver operating characteristic curve (AUC) of 0.86, 0.85, 0.85, and 0.80, respectively. +other 31009404 hsa-mir-93 Pancreatic Carcinoma 5p showed the highest discriminating capacity for pancreatic neoplasia (PDAC or IPMN) with an area under the receiver operating characteristic curve (AUC) of 0.86, 0.85, 0.85, and 0.80, respectively. +other 31009404 hsa-mir-33a Pancreatic Carcinoma "2-miRNA combinations improved these performances reaching AUC = 0.90 for ""miR-33a-3p+miR-320a."" Addition of CA19.9 increased the diagnostic potential of miRNA signatures even further achieving an AUC of 0.95 (93% sensitivity and 85% specificity) for the combination of ""miR-33a-3p+miR-320a+CA19.9."" CONCLUSIONS: Novel signatures combining miRNAs and CA19.9 could be used as noninvasive biomarkers for early detection of PDAC." +other 31009404 hsa-mir-20a Pancreatic Carcinoma "2-miRNA combinations improved these performances reaching AUC = 0.90 for ""miR-33a-3p+miR-320a."" Addition of CA19.9 increased the diagnostic potential of miRNA signatures even further achieving an AUC of 0.95 (93% sensitivity and 85% specificity) for the combination of ""miR-33a-3p+miR-320a+CA19.9."" CONCLUSIONS: Novel signatures combining miRNAs and CA19.9 could be used as noninvasive biomarkers for early detection of PDAC." +genetics_GWAS 31009294 hsa-mir-155 Arthritis, Rheumatoid Significant overexpression of miR-155 and higher levels of IMA were detected in patients with RA compared with those in controls (P < 0.0001). +lncRNA target 31009242 hsa-mir-370 Breast Neoplasms The roles of miR-370 in breast cancer are investigated, and its downstream targets are identified. +genetics_knock down_promote 31009138 hsa-mir-188 Stomach Neoplasms Knockdown of SALL4 eliminated the effect of miR +genetics_GWAS 31008529 hsa-mir-490 Glioblastoma Overall, this stands as a first study that provides a direct link between epigenetic modulator EZH2 and oncogenic TGF-beta signaling involving novel miR +other 31008486 hsa-mir-494 Diabetes Mellitus 3p reduces insulin sensitivity in diabetic cardiomyocytes by down-regulating IRS1. +transcription factor target 31007850 hsa-mir-96 Breast Neoplasms We previously demonstrated that miR-96 has a suppressive effect on breast cancer aggressiveness and that this effect was mediated by ABCE1 gene regulation. +circulation_biomarker_diagnosis_up 31007750 hsa-mir-142 Cholangiocarcinoma In summary, the results of the present study provide novel data indicating that plasma miR +genetics_overexpression_promote 31007746 hsa-mir-766 Colonic Neoplasms The overexpression of miRNA-766 reduced cell growth and induced apoptosis in colon cancer cells through suppression of the MDM4/p53 pathway. +transcription factor target 31007650 hsa-mir-126 Uterine Cervical Neoplasms CONCLUSION: miR-126 functions as a tumor suppressor in cervical cancer cells in vitro, which inhibits the proliferation, migration and invasion by suppressing MMP2, MMP9 expression and inactivating JAK2/STAT3 signaling pathway through targeting ZEB1, suggesting that miR-126 might be a novel potential target for the diagnosis and treatment of patients with cervical cancer. +lncRNA target 31007083 hsa-mir-384 Osteosarcoma SLBP may be a potential therapeutic target for osteosarcoma therapy. +circulation_biomarker_diagnosis_up 31006985 hsa-let-7b Pancreatic Carcinoma 3p) panel in the serum for PC early and noninvasive diagnosis. +circulation_biomarker_diagnosis_up 31006985 hsa-mir-223 Pancreatic Carcinoma 3p) panel in the serum for PC early and noninvasive diagnosis. +circulation_biomarker_diagnosis_up 31006985 hsa-mir-25 Pancreatic Carcinoma 3p) panel in the serum for PC early and noninvasive diagnosis. +lncRNA target 31006800 hsa-mir-27b Endometrial Neoplasms miR-27b-3p/MARCH7 may also regulate EC cell invasion and metastasis via the Snail-mediated pathway. +transcription factor target 31006667 hsa-mir-342 Carcinoma, Hepatocellular CONCLUSION: Up-regulation of miR-342 inhibited cell proliferation and induced cell apoptosis in HCC by inhibiting Wnt/beta-catenin signaling pathway, suggesting that miR-342 might act as a promising tumor gene therapeutic target for HCC patients. +circulation_biomarker_prognosis_down 31006664 hsa-mir-497 Colorectal Neoplasms CONCLUSIONS: Collectively, serum miR-497 may serve as a promising biomarker for diagnosis and prognosis of CRC. +genetics_overexpression_suppress 31006663 hsa-mir-1285 Osteosarcoma Moreover, overexpression of YAP1 reversed the inhibitory effects of miR +exosome 31006167 hsa-mir-204 Carcinoma, Renal Cell 5p in urinary exosomes could be a useful biomarker for early diagnosis of patients with Xp11 tRCC. +circulation_biomarker_diagnosis_ns 31005556 hsa-mir-30 Carcinoma, Hepatocellular 5p, and TLN1 altered by delivering plasmids into Hep3B cell line. +other 31005516 hsa-mir-206 Acquired Immunodeficiency Syndrome To detect eclipse stage of HIV-1 infection we also developed a four-miRNA based (miR5p, miR-206, let-7g-3p, and miR-181c-3p) panel (P(E)) with AUC 0.999 (0.995-1.000), 100% sensitivity and 95.8% specificity. +other 31005516 hsa-mir-181c Acquired Immunodeficiency Syndrome To detect eclipse stage of HIV-1 infection we also developed a four-miRNA based (miR5p, miR-206, let-7g-3p, and miR-181c-3p) panel (P(E)) with AUC 0.999 (0.995-1.000), 100% sensitivity and 95.8% specificity. +lncRNA target 31005375 hsa-mir-24 Diabetes Mellitus CONCLUSION: The up-regulation of miR-24 significantly attenuated vascular remodeling both in balloon-injured diabetic rats and HG-stimulated VSMCs via suppression of proliferation, migration and collagen deposition by acting on PIK3R1 gene that modulated the PI3K/Akt/mTOR axes. +lncRNA target 31005252 hsa-mir-133a Carcinoma, Non-Small-Cell Lung Therefore, these findings advocate targeting the circP4HB/miR-133a-5p/vimentin axis as a potential therapeutic option for NSCLC patients. +genetics_overexpression_promote 31004884 hsa-mir-20b Esophageal Squamous Cell Carcinoma MiR-20b was markedly upregulated in the setting of IR and overexpression of miR-20b disrupted glucose metabolism by repressing SMAD7 in L6 cells. +genetics_overexpression_promote 31004884 hsa-mir-20b Insulin Resistance MiR-20b was markedly upregulated in the setting of IR and overexpression of miR-20b disrupted glucose metabolism by repressing SMAD7 in L6 cells. CONCLUSION: Emodin improves glucose metabolism to produce anti-IR effects, and downregulation of miR-20b thereby upregulation of SMAD7 is an underlying mechanism for the beneficial effects of emodin. +other 31004838 hsa-mir-141 Pneumonia, Mycoplasma MiR-141 and CXCL12beta (C-X-C motif chemokine ligand 12) signaling regulate trophoblast invasion and vascularization capabilities during PE pathogenesis; however, their interactions and underlying mechanisms of action remain unclear. +lncRNA target 31004734 hsa-mir-124 Ischemic Stroke Further results demonstrated that an inhibitor of Akt could decrease the increased protein expression of GLT-1 induced by miR-124 mimics, and an inhibitor of mTOR could increase the reduced protein expression of GLT-1 caused by a miR-124 inhibitor in astrocytes injured by different OGD/reperfusion conditions. +lncRNA target 31004703 hsa-mir-374a Triple Negative Breast Neoplasms miR-374a-5p was also found to directly target arrestin beta 1 (ARRB1) that is specifically downregulated in TNBC patients in several human genomic datasets. +transcription factor target 31004656 hsa-mir-27a Pulmonary Arterial Hypertension Thus, targeting of miR-27a-related pathway may be therapeutically harnessed to treat PAH. +transcription factor target 31004655 hsa-mir-155 Primary Graft Dysfunction Here, we summarized related evidence to explore the correlation between the dysregulation of miR-155 and various allograft dysfunction in transplant recipients, and verified the dynamic change of miR-155 level in acute rejection (AR) using a rat renal transplantation model. +circulation_biomarker_diagnosis_up 31004655 hsa-mir-155 Aortic Valve Insufficiency Expression of miR-155 in plasma was significantly increased in 7d and 9d post-transplantation compared to the control group (P<0.05), and was consistent with the dynamic change of AR degree. +lncRNA target 31004603 hsa-mir-32 Nasopharyngeal Carcinoma And over-expression of miR-32 promoted the nasopharyngeal carcinoma cells growth, migration and invasion, and suppressed apoptosis. +other 31004593 hsa-mir-625 Nerve Degeneration Overall, our study identified a new lnc-p21-miRTRPM2 regulatory network that lnc-p21 regulated MPP -induced neuronal injury by sponging miR-625 and upregulating TRPM2 in SH-SY5Y cells, which provide a better understanding for the pathogenesis of PD. +lncRNA target 31004447 hsa-mir-338 Carcinoma, Hepatocellular 3p/PKM2 axis under hypoxia, which may provide a therapeutic target for HCC. +genetics_overexpression_promote 31004350 hsa-mir-22 Hypoxia The effects of C2dat1 on H9c2 cells injured by hypoxia were attenuated when miR-22 was overexpressed. +lncRNA target 31004260 hsa-mir-195 Neuralgia To investigate the pathophysiological role of miR-195 and Shh signaling in TN, persistent facial pain was induced by infraorbital nerve chronic constriction injury (CCI-IoN), and facial pain responses were evaluated by Von Frey hairs. These results suggest that miR-195 is involved in the development of TN by targeting Patched1 in the Shh signaling pathway, thus regulating extracellular glutamate. +other 31004080 hsa-mir-516a-2 Melanoma Survival analysis identified seven differentially expressed mRNAs, five differentially expressed miRNAs (miRNA-29c, miRNA-100, miR3p, miR-150, miR-516a-2), and six differentially expressed lncRNAs (AC068594.1, C7orf71, FAM41C, GPC5-AS1, MUC19, LINC00402) that were correlated with survival time in patients with metastatic melanoma. +other 31004080 hsa-mir-29c Melanoma Survival analysis identified seven differentially expressed mRNAs, five differentially expressed miRNAs (miRNA-29c, miRNA-100, miR3p, miR-150, miR-516a-2), and six differentially expressed lncRNAs (AC068594.1, C7orf71, FAM41C, GPC5-AS1, MUC19, LINC00402) that were correlated with survival time in patients with metastatic melanoma. +other 31004080 hsa-mir-142 Melanoma Survival analysis identified seven differentially expressed mRNAs, five differentially expressed miRNAs (miRNA-29c, miRNA-100, miR3p, miR-150, miR-516a-2), and six differentially expressed lncRNAs (AC068594.1, C7orf71, FAM41C, GPC5-AS1, MUC19, LINC00402) that were correlated with survival time in patients with metastatic melanoma. +other 31004080 hsa-mir-150 Melanoma Survival analysis identified seven differentially expressed mRNAs, five differentially expressed miRNAs (miRNA-29c, miRNA-100, miR3p, miR-150, miR-516a-2), and six differentially expressed lncRNAs (AC068594.1, C7orf71, FAM41C, GPC5-AS1, MUC19, LINC00402) that were correlated with survival time in patients with metastatic melanoma. +other 31004080 hsa-mir-100 Melanoma Survival analysis identified seven differentially expressed mRNAs, five differentially expressed miRNAs (miRNA-29c, miRNA-100, miR3p, miR-150, miR-516a-2), and six differentially expressed lncRNAs (AC068594.1, C7orf71, FAM41C, GPC5-AS1, MUC19, LINC00402) that were correlated with survival time in patients with metastatic melanoma. +transcription factor target 31004009 hsa-mir-137 Glioblastoma In gliomas, miR-137 functions as a tumor suppressor while Msi1 is a prooncogenic factor. We suggest that the balance between Msi1 and miR-137 is a key determinant in cell fate decisions and disruption of this balance could contribute to neurodegenerative diseases and glioma development. +transcription factor target 31003790 hsa-mir-26a Obesity Among them, miR-15b, miR-26a, miR-301, miR-30b, and miR-30c had more predicted obesity-related target genes than other miRNAs. +transcription factor target 31003790 hsa-mir-15b Obesity Among them, miR-15b, miR-26a, miR-301, miR-30b, and miR-30c had more predicted obesity-related target genes than other miRNAs. +other 31003776 hsa-mir-24 Cholangiocarcinoma Moreover, luciferase reporter and rescue assays indicated that LOXL1-AS1 functioned as a ceRNA to elevate ATP-binding cassette transporter A1 (ABCA1) level by sponging miR3p and exhibited the malignant phenotypes of CCA cells, thereby playing an oncogenic role in CCA. +genetics_overexpression_promote 31003211 hsa-mir-448 Glioma Interestingly, overexpression of miR-448 increased the x-radiation sensitivity of glioma cells. +lncRNA target 31003188 hsa-mir-181b Cognition Disorders They also highlight the importance of studying miRNAs in the context of POCD and identify miR-181b-5p as a novel potential therapeutic target for improving POCD. +lncRNA target 31003188 hsa-mir-181b Postoperative Cognitive Complications They also highlight the importance of studying miRNAs in the context of POCD and identify miR-181b-5p as a novel potential therapeutic target for improving POCD. +circulation_biomarker_prognosis_ns 31002820 hsa-mir-150 Diabetic Retinopathy 3p and miR-30b-5p extracted from circulating EVs as prognostic biomarkers for diabetic retinopathy. +circulation_biomarker_prognosis_ns 31002820 hsa-mir-150 Diabetes Mellitus 3p and miR-30b-5p extracted from circulating EVs as prognostic biomarkers for diabetic retinopathy. +circulation_biomarker_prognosis_ns 31002820 hsa-mir-21 Diabetic Retinopathy 3p and miR-30b-5p extracted from circulating EVs as prognostic biomarkers for diabetic retinopathy. +circulation_biomarker_prognosis_ns 31002820 hsa-mir-21 Diabetes Mellitus 3p and miR-30b-5p extracted from circulating EVs as prognostic biomarkers for diabetic retinopathy. +genetics_overexpression_promote 31002531 hsa-mir-21 Prostatic Neoplasms Overexpression of miR-21 promoted androgen-dependent and -independent PCa cell proliferation, migration, invasion, and resistance to apoptosis. +other 31002371 hsa-mir-145 Breast Neoplasms The aim of the present study was to ascertain whether miR1455p could discriminate between pCR and nopCR in triplenegative breast cancer patients that received a cisplatin/doxorubicinbased neoadjuvant treatment. In conclusion, miR1455p could be a potential biomarker of clinical response to NeoCh in triplenegative breast cancer. +genetics_knock down_promote 31002360 hsa-mir-888 Adenocarcinoma of Lung Overexpression of miR888 promoted the invasion and migration of lung adenocarcinoma A549 cells by targeting Ecadherin and tissue inhibitor of metalloproteinase 2. +other 31002170 hsa-mir-126 Hypertension, Pulmonary This study aimed to evaluate the role of miRNA-126 (miR-126) and its associated signaling pathways and specific mechanisms for the pathogenesis of PAH. +genetics_overexpression_suppress 31002164 hsa-mir-129 Lung Neoplasms In addition, the recovery experiment demonstrated that overexpression of VEGF could counteract the impact of microRNA +lncRNA target 31002163 hsa-mir-940 Abortion, Septic CONCLUSIONS MicroRNA-940 is highly expressed in the placental villi of early abortion pregnancies and promotes the occurrence of early abortion by inhibiting the proliferation of trophoblast cells by targeting ZNF672. +lncRNA target 31002156 hsa-mir-92a Diabetes Mellitus, Type 2 MiR-92a may contribute to the development of CAD through activation of NF-B and downstream inflammatory pathways. +lncRNA target 31002156 hsa-mir-92a Cardiovascular Diseases MiR-92a may contribute to the development of CAD through activation of NF-B and downstream inflammatory pathways. +other 31002155 hsa-mir-181b Pulpitis CONCLUSIONS: The decline in the miR-181b expression may be an important factor in AS plaque formation and vascular endothelial injury by regulating Notch1. +lncRNA target 31002154 hsa-mir-34a Myocardial Infarction, Acute OBJECTIVE: To study the influence of micro-ribonucleic acid (miR)-34a on myocardial apoptosis in rats with acute myocardial infarction (AMI) through the extracellular signal-regulated kinase 1/2 (ERK1/2) pathway. CONCLUSIONS: MiR-34a affects the apoptosis in AMI by regulating the ERK1/2 signaling pathway. +circulation_biomarker_diagnosis_up 31002148 hsa-mir-494 Sepsis RESULTS: Plasma level of microRNA +lncRNA target 31002141 hsa-mir-608 Leukemia, Myeloid, Acute Furthermore, DDA1 could reverse the inhibitory effect of microRNA-608 on proliferative ability and cell cycle progression of AML cells. +genetics_overexpression_promote 31002138 hsa-mir-770 Glioma Then, functional assays indicated that overexpression of miR-770 suppressed proliferation, migration, invasion and EMT pathway, and induced the apoptosis of glioma cells in vitro. +lncRNA target 31002136 hsa-mir-506 Thyroid Cancer, Papillary CONCLUSIONS: In this study, we found that miR-506 could inhibit the proliferation and metastasis of PTC cells. +genetics_knock down_promote 31002133 hsa-mir-150 Nasopharyngeal Carcinoma 5p knockdown in NPC cells showed the opposite effect on cellular behaviors of NPC cells. +genetics_overexpression_promote 31002132 hsa-mir-485 Esophageal Squamous Cell Carcinoma 5p overexpression inhibited cell proliferation, migration, and invasion in EC cell lines. +lncRNA target 31002131 hsa-mir-4317 Stomach Neoplasms OBJECTIVE: Previous studies have revealed that miR-4317 was abnormally expressed and functioned as a tumor suppressor in several tumors, including gastric cancer (GC). +lncRNA target 31002128 hsa-mir-145 Carcinoma, Hepatocellular CONCLUSIONS: We showed that miR-145 can target and downregulate ROCK1 expression, and it controls HCC by inhibiting the cell cycle and activating apoptosis via the ROCK1/NF-kappaB signaling pathway. +circulation_biomarker_diagnosis_up 31002120 hsa-mir-1207 Femur Head Necrosis 5p is significantly up-regulated in necrotic femoral head tissue and serum of SNFH patients. +lncRNA target 31002119 hsa-mir-543 Spinal Cord Injuries 3p can inhibit the activity of NF-kappaB by suppressing the inflammatory aggravation of TNFSF15 and decreasing its product TL1A. +genetics_overexpression_promote 31001891 hsa-mir-197 Fibrosarcoma Interestingly, we did not observe any significant changes in cell cycle pattern or apoptotic cell populations, but rather noticed cellular senescence of fibrosarcoma cells upon overexpression of miR +genetics_knock down_promote 31001854 hsa-mir-143 Nasopharyngeal Carcinoma Overexperssion of miR-143 or FMNL1 knockdown inhibited cell proliferation, migration, and invasion in NPC cells (P < 0.05). +genetics_knock down_suppress 31001849 hsa-mir-24 Breast Neoplasms 3p overexpression in mediating the development of tamoxifen resistance in breast cancer and suggested miR +other 31001642 hsa-mir-1 Crohn Disease miR5p expression was driven by location and may be a biomarker for location subtypes in CD. +other 31001629 hsa-mir-3164 Triple Negative Breast Neoplasms Altogether, our research revealed the pivotal role of circRAD18-miR-208a/3164-IGF1/FGF2 axis in TNBC tumorigenesis and metastasis though the mechanism of competing endogenous RNAs. +other 31001629 hsa-mir-208a Triple Negative Breast Neoplasms Altogether, our research revealed the pivotal role of circRAD18-miR-208a/3164-IGF1/FGF2 axis in TNBC tumorigenesis and metastasis though the mechanism of competing endogenous RNAs. +transcription factor target 31000329 hsa-mir-125b Dementia In conclusion, miR-125b targeting p38MAPK might be involved with modifying learning, memorizing and cognitive abilities of rats that were managed with intermittent hypoxia, which might provide theoretical basis for treating intermittent hypoxia-related dementia. +genetics_overexpression_promote 31000197 hsa-mir-4500 Glioma Functional studies show that ectopic miR-4500 overexpression inhibited glioma cell growth, survival, proliferation, migration and invasion. +lncRNA target 30999937 hsa-mir-181a Urinary Bladder Neoplasms Mechanistically, hsa_circ_0068871 upregulated FGFR3 expression and activated STAT3 by targeting miR-181a-5p to promote BCa progression. +genetics_overexpression_promote 30999814 hsa-mir-200b Stomach Neoplasms MiR-200b overexpression suppressed the proliferation, cell cycle process, and Wnt/beta-catenin signaling of gastric cancer cells. +other 30999696 hsa-mir-21 Colorectal Neoplasms In conclusion, we report that miR-21 is not linked to expression of the pro-inflammatory cytokine TNF- mRNA, but that miR-21 and TNF- both take part in the cancer expansion at the invasive front of colon cancers. +other 30999277 hsa-mir-200a Hypogonadism Since the lack of certain miRNAs in animal models has led to cHH, we sequenced human miRNAs predicted to regulate cHH-related genes (MIR7-3, MIR141, MIR429 and MIR200A-C) in 24 cHH patients with Sanger sequencing. +other 30999277 hsa-mir-141 Hypogonadism Since the lack of certain miRNAs in animal models has led to cHH, we sequenced human miRNAs predicted to regulate cHH-related genes (MIR7-3, MIR141, MIR429 and MIR200A-C) in 24 cHH patients with Sanger sequencing. +other 30999277 hsa-mir-429 Hypogonadism Since the lack of certain miRNAs in animal models has led to cHH, we sequenced human miRNAs predicted to regulate cHH-related genes (MIR7-3, MIR141, MIR429 and MIR200A-C) in 24 cHH patients with Sanger sequencing. +other 30999277 hsa-mir-7 Hypogonadism Since the lack of certain miRNAs in animal models has led to cHH, we sequenced human miRNAs predicted to regulate cHH-related genes (MIR7-3, MIR141, MIR429 and MIR200A-C) in 24 cHH patients with Sanger sequencing. +other 30999277 hsa-mir-200c Hypogonadism Since the lack of certain miRNAs in animal models has led to cHH, we sequenced human miRNAs predicted to regulate cHH-related genes (MIR7-3, MIR141, MIR429 and MIR200A-C) in 24 cHH patients with Sanger sequencing. +lncRNA target 30999114 hsa-mir-219a Carcinoma, Non-Small-Cell Lung In conclusion, this study demonstrated miR-219a-5p plays a crucial role in the development of acquired drug resistance to DDP in NSCLC cells by targeting FGF9 and might be a therapeutic target for DDP resistance in clinical practice. +lncRNA target 30999112 hsa-mir-204 Cystitis In addition, we illustrated that miR-204 exerted its function via targeting CYCLIN D2 (CCND2) 3'UTR at mRNA level in pCGs. +lncRNA target 30998968 hsa-mir-496 Osteosarcoma With the purpose of identifying the functional role miR-496 in OS, cell proliferation, migration, and invasion were measured in cells treated with miR-496 mimic or inhibitor. +lncRNA target 30998966 hsa-mir-143 Myocardial Infarction CONCLUSIONS: lncUCA1 might protect cardiomyocyte against H/R induced apoptosis by suppressing miR-143 and modulated the following downstream MDM2/p53 signaling pathway, indicating the therapeutic potential of targeting lncUCA1 for MI. +transcription factor target 30998152 hsa-mir-155 Lymphoma, Large B-Cell, Diffuse DB cells were cultured and divided into miR-155 inhibitor, negative control and blank groups. The specific inhibition of miR-155 expression in DB cells can reduce cell proliferation, accelerate cell apoptosis, and inhibit cell migration and invasion. +circulation_biomarker_diagnosis_up 30998140 hsa-mir-138 Leukemia, Myeloid, Acute 5p in the peripheral blood mononuclear cells of patients with acute myeloid leukemia. +other 30997877 hsa-mir-205 Diabetic Nephropathies MiR-205 is an independent risk factor for sepsis-induced AKI and its decreased expression is associated with shorter patient survival. +other 30997877 hsa-mir-205 Sepsis MiR-205 is an independent risk factor for sepsis-induced AKI and its decreased expression is associated with shorter patient survival. +circulation_biomarker_diagnosis_ns 30997863 hsa-mir-21 ankylosing spondylitis 1 In summary, serum miR-21 expressions were related to structural damage and radiological progression in AS, indicating that miR-21 may act as a switch between inflammation and new bone information and regulate different signal ways between lesioned enthesis and trabecular bone. +lncRNA target 30997746 hsa-mir-760 Colorectal Neoplasms mediated PPP1R1B expression via the cAMP signalling pathway. +other 30997674 hsa-mir-338 Leukemia, Myeloid, Acute Our study suggests that high expression of miR-338 is an adverse prognostic biomarker in patients with AML undergoing chemotherapy and may guide treatment decisions for AML. +genetics_GWAS 30997628 hsa-mir-148a Colorectal Neoplasms The results of dysregulated epigenetic changes of miR-21 clearly showed upregulation of expression in colorectal adenocarcinoma, compared to non-neoplastic mucosa, in colorectal adenoma vs non-neoplastic mucosa: (p<0.001) and in CRC versus adenoma (p<0.001); while miR-148a expression were significantly downregulated in CRC, compared to non-neoplastic mucosa, in colorectal adenoma vs non-neoplastic mucosa, and in adenoma vs CRC (p<0.001). Our findings support the important role of miR-21 in stages I-II of CRC, and the KRAS G12D mutant, and differential miR-148a expression, in advanced stages of CRC. +genetics_GWAS 30997628 hsa-mir-21 Colorectal Neoplasms The results of dysregulated epigenetic changes of miR-21 clearly showed upregulation of expression in colorectal adenocarcinoma, compared to non-neoplastic mucosa, in colorectal adenoma vs non-neoplastic mucosa: (p<0.001) and in CRC versus adenoma (p<0.001); while miR-148a expression were significantly downregulated in CRC, compared to non-neoplastic mucosa, in colorectal adenoma vs non-neoplastic mucosa, and in adenoma vs CRC (p<0.001). Our findings support the important role of miR-21 in stages I-II of CRC, and the KRAS G12D mutant, and differential miR-148a expression, in advanced stages of CRC. +other 30997501 hsa-mir-122 Hepatitis C Doubly depleting TNRC6B and TNRC6C proteins reduced HCV replication in human hepatoma cells, dampening miR-122 stimulation of viral RNA synthesis without reducing the stability or translational activity of the viral RNA. +genetics_GWAS 30996386 hsa-mir-206 Dermatomyositis Recent studies have also found a series of epigenetic markers related to the occurrence and development of DM/PM, mainly in the aspect of non-coding RNA changes, such as miR-10a, miR-206, etc. +genetics_GWAS 30996386 hsa-mir-10a Dermatomyositis Recent studies have also found a series of epigenetic markers related to the occurrence and development of DM/PM, mainly in the aspect of non-coding RNA changes, such as miR-10a, miR-206, etc. +genetics_GWAS 30996386 hsa-mir-206 Polymyositis Recent studies have also found a series of epigenetic markers related to the occurrence and development of DM/PM, mainly in the aspect of non-coding RNA changes, such as miR-10a, miR-206, etc. +genetics_GWAS 30996386 hsa-mir-10a Polymyositis Recent studies have also found a series of epigenetic markers related to the occurrence and development of DM/PM, mainly in the aspect of non-coding RNA changes, such as miR-10a, miR-206, etc. +transcription factor target 30995936 hsa-mir-365a Carcinoma, Non-Small-Cell Lung CONCLUSION: Our results highlighted the importance of dysregulated miR-365a-5p-PELI3 signaling axis in NSCLC. +lncRNA target 30995921 hsa-let-7b Glioma CONCLUSIONS This study provides four potential biomarkers for the diagnosis of glioma, offers a potential explanation of its pathogenesis, and proposes hsa-let-7b-5p as a therapeutic target. +other 30995872 hsa-mir-124 Parkinson Disease MicroRNA-124 regulates the expression of p62/p38 and promotes autophagy in the inflammatory pathogenesis of Parkinson's disease. MicroRNA-124 regulates the expression of p62/p38 and promotes autophagy in the inflammatory pathogenesis of Parkinson's disease. +genetics_knock down_promote 30995540 hsa-mir-596 Glioma Moreover, overexpression of CREPT partially reversed the miR +genetics_GWAS 30995246 hsa-mir-10b Melanoma We observed that miR-10b expression correlates with the presence of the oncogenic B-Raf (B-RafV600E) mutation in melanoma cells. +genetics_overexpression_promote 30994959 hsa-mir-27a Melanoma Furthermore, miR-27a targeted SYK and silencing of miR-27a or overexpression of SYK cells promoted autophagy and apoptosis of melanoma cells and reduced their tumorigenic ability in vivo. +circulation_biomarker_diagnosis_ns 30994325 hsa-mir-21 Carcinoma, Non-Small-Cell Lung The platform was also successfully used to directly detect hsa-miR5p in eight non-small cell lung cancer plasma samples. +other 30993882 hsa-mir-210 Fetal Growth Retardation 3p may contribute to impaired placentation of the smaller twin by decreasing FGF1 expression in sIUGR. +circRNA target 30993801 hsa-mir-1299 Breast Neoplasms Upregulation of hsa_circ_0136666 contributes to breast cancer progression by sponging miR-1299 and targeting CDK6. In conclusion, it was revealed that Upregulation of hsa_circ_0136666 promoted breast cancer progression by sponging miR-1299 and targeting CDK6. +genetics_overexpression_promote 30993760 hsa-mir-193b Myocardial Reperfusion Injury Furthermore, overexpression of miR-193b could alleviate the apoptosis level after myocardial I/R injury. +genetics_overexpression_promote 30993715 hsa-mir-186 Retinoblastoma Overexpression of miR-186 attenuates RB via the inactivation of the Hedgehog signaling pathway by downregulating ATAD2. +genetics_overexpression_promote 30993707 hsa-mir-190 Breast Neoplasms Collectively, the findings suggested that overexpression of miR-190 inhibited EMT and angiogenesis by inactivating AKT-ERK signaling pathway via STC2 in BC. +genetics_knock down_promote 30993701 hsa-mir-135a Lung Neoplasms We validated their direct correlation and moreover, overexpression of miR-135a-5p restrained LOXL4 levels in lung cancer cells. +genetics_knock down_promote 30993113 hsa-mir-182 Osteosarcoma 3p in OS cells results in overexpression of EBF2 and promotes the progression of OS. +lncRNA target 30993110 hsa-mir-29a Osteoarthritis These data reveal that miR-29a/Bax axis plays an important role in regulating chondrocyte apoptosis and suggest that targeting the proapoptotic protein Bax and increasing expression levels of miR-29a emerge as potential approach for protection against the development of OA. +other 30992737 hsa-mir-25 Inflammation Changes in the levels of antiapoptosis microRNA-25 (miR-25) have been linked with heart disease, inflammation, VSMC phenotype, oxidative stress, and apoptosis. +other 30992737 hsa-mir-25 Heart Diseases Changes in the levels of antiapoptosis microRNA-25 (miR-25) have been linked with heart disease, inflammation, VSMC phenotype, oxidative stress, and apoptosis. +other 30992737 hsa-mir-25 Plaque, Atherosclerotic Therapeutic manipulation of miR-25 may reduce atherosclerosis and unstable plaque formation associated with chronic stress. +genetics_overexpression_promote 30992673 hsa-mir-664 Carcinoma, Hepatocellular CONCLUSION: All data indicated that overexpression of miR-664 is associated with poor prognosis of HCC patients, and may enhance tumor progression of HCC by targeting SIVA1. +lncRNA target 30992669 hsa-mir-221 Thyroid Cancer, Papillary CONCLUSION: MiR-221 may be involved in PTC cell invasion and metastasis by targeting RECK, indicating that the miR-221/RECK pathway could be studied further as a potential new diagnostic or prognostic biomarker for PTC. +transcription factor target 30992660 hsa-mir-106a Atrial Fibrillation Moreover, melatonin contributed to the translation and transcription of autophagy-related protein ATG7 and inhibited the function of miR-106a-5p in AF cells. In addition, the results suggested that miR-106a-5p mediated the expression of ATG7 by directly binding to its 3'UTR in AF cells. +transcription factor target 30992394 hsa-mir-205 Glioma In summary, our findings demonstrated that miR-205 suppresses glioma tumor growth, invasion, and reverses EMT through down-regulating its target HOXD9. +lncRNA target 30992025 hsa-mir-151a Glioblastoma SBF2-AS1 functions as a ceRNA for miR-151a-3p, leading to the disinhibition of its endogenous target, X-ray repair cross complementing 4 (XRCC4), which enhances DSB repair in GBM cells. +other 30991875 hsa-mir-661 Carcinoma, Squamous Cell In addition, the levels of mature miR-661 mRNA and PLEC protein were significantly upregulated in SCC tissues compared with SNIP samples. +other 30991875 hsa-mir-661 Papilloma, Inverted In addition, the levels of mature miR-661 mRNA and PLEC protein were significantly upregulated in SCC tissues compared with SNIP samples. +lncRNA target 30991448 hsa-let-7i Carcinoma, Hepatocellular Conclusion: Our findings suggest that the HDAC6-let-7i-5p-TSP1 regulatory pathway suppresses neoplastic and antiphagocytic behaviors of HCC by interacting with cell surface receptor CD47 in HCC and neighboring cells of tumor microenvironment, providing a therapeutic target for the treatment of liver malignancy and metastasis. +lncRNA target 30991076 hsa-mir-143 Pancreatic Carcinoma 5p-targeted AGR2 expression, providing a potential target for pancreatic cancer treatment. +transcription factor target 30991045 hsa-mir-199 Lupus Erythematosus, Systemic In this study, we investigated the mechanism through which miR +other 30991034 hsa-let-7a Aortic Aneurysm, Abdominal Collectively, our study revealed a pathogenic H19/let-7a/IL-6 inflammatory pathway in AAA formation, which offers a new potential therapeutic strategy for AAA. +other 30991034 hsa-let-7a Vasculitis Collectively, our study revealed a pathogenic H19/let-7a/IL-6 inflammatory pathway in AAA formation, which offers a new potential therapeutic strategy for AAA. +other 30990573 hsa-mir-21 Stomach Neoplasms H pylori eradication can result in a 70% SPEM regression, accompanied by a decline in miR-21, 155, and 233 expression levels. +lncRNA target 30990378 hsa-mir-4261 Squamous Cell Carcinoma of Head and Neck DKK2-Wnt/beta-catenin signalling axis in ESCC, and MEG3 could represent a novel diagnostic and prognostic biomarker and therapeutic target in ESCC. +lncRNA target 30990343 hsa-mir-1225 Pancreatic Carcinoma Silencing of JAK1 expression counteracted the suppressive influence of miR-1225 depletion in PC cells. +other 30990253 hsa-mir-126 ankylosing spondylitis 1 3p expression in PBMCs of patients with axSpA, and the expression of these four miRNAs might be used as useful diagnostic markers in axSpA. +other 30990253 hsa-mir-27a ankylosing spondylitis 1 3p. +other 30990253 hsa-mir-17 ankylosing spondylitis 1 3p expression in PBMCs of patients with axSpA, and the expression of these four miRNAs might be used as useful diagnostic markers in axSpA. +other 30990253 hsa-mir-29a ankylosing spondylitis 1 3p. +genetics_GWAS 30989725 hsa-mir-34a Osteoporosis "One single-nucleotide polymorphism located within the 3'-untranslated region (3'-UTR) of TLR4 may ""generate"" binding site of miR-34a and thereby associated with risk of OP. The regulatory association between rs1057317 polymorphism in TLR4 3'-UTR led to an inhibitory effect on the expression of TLR4 by miR-34a, which may explain the observed association between the polymorphism and the susceptibility to OP." +other 30989723 hsa-mir-145 Aortic Aneurysm MIAT expression was significantly increased, and miR-145 expression was markedly reduced in thoracic aortic aneurysms compared with normal thoracic aortic tissues. +other 30989723 hsa-mir-145 Aortic Aneurysm, Thoracic MIAT expression was significantly increased, and miR-145 expression was markedly reduced in thoracic aortic aneurysms compared with normal thoracic aortic tissues. +lncRNA target 30989715 hsa-mir-340 Myocardial Infarction Therapeutic strategies that target miR +lncRNA target 30989715 hsa-mir-340 Reperfusion Injury Therapeutic strategies that target miR +other 30989715 hsa-mir-340 Ischemic Stroke MiR5p was reported to be downregulated in acute ischemic stroke. +genetics_overexpression_promote 30989711 hsa-mir-146a Periodontitis miRNA-146a overexpression led to downregulated IL-17 and IL-35 expression in PDLSCs isolated from periodontitis-affected teeth. +other 30989656 hsa-mir-124 Cholangiocarcinoma Together, these findings demonstrate that UHRF1, regulated by miR3p, acts as a tumor promoter by promoting cell proliferation in ICC. +other 30989649 hsa-mir-29b Polycystic Ovary Syndrome Meanwhile, the H19/miR-29b-3p/MMP-9 and H19/miR-29b-3p/MMP-2 signaling pathways were implicated in PCOS, in which the interactions between H19/miR-29b-3p and MMP-9/MMP-2/miR-29b-3p were confirmed. +lncRNA target 30989460 hsa-mir-106b Carcinoma, Ductal, Breast CONCLUSION miR-106b-5p and miR5p might have a role in breast cancer recurrence and progression by suppressing TGF- activity, leading to early breast cancer carcinogenesis. +lncRNA target 30989460 hsa-mir-17 Carcinoma, Ductal, Breast CONCLUSION miR-106b-5p and miR5p might have a role in breast cancer recurrence and progression by suppressing TGF- activity, leading to early breast cancer carcinogenesis. +other 30988818 hsa-mir-126 Carcinoma, Renal Cell The results of the present study indicate that of the 3 miRNAs investigated, the expression of miR-126 has the strongest potential as a prognostic biomarker for patients suffering from ccRCC. +exosome 30988815 hsa-mir-375 Atrial Premature Complexes In conclusion, the present study may lead to further investigation of the function role of exosomal miR-375 in the activation and differentiation of osteoblasts in PCa. +transcription factor target 30988813 hsa-mir-148a Urinary Bladder Neoplasms 5p, miR-148a-3p and miR-608 promoted proliferation of bladder cancer T24 cells and inhibited apoptosis of the cells and showed potential to become a new target for the future treatment of bladder cancer. +transcription factor target 30988813 hsa-mir-608 Urinary Bladder Neoplasms 5p, miR-148a-3p and miR-608 promoted proliferation of bladder cancer T24 cells and inhibited apoptosis of the cells and showed potential to become a new target for the future treatment of bladder cancer. +transcription factor target 30988813 hsa-mir-490 Urinary Bladder Neoplasms 5p, miR-148a-3p and miR-608 promoted proliferation of bladder cancer T24 cells and inhibited apoptosis of the cells and showed potential to become a new target for the future treatment of bladder cancer. +genetics_overexpression_promote 30988802 hsa-mir-28 Melanoma 5p in melanoma cells, and HOXB3 overexpression reversed the suppressive effects of UCA1 downregulation on melanoma cell proliferation and migration. +genetics_overexpression_promote 30988799 hsa-mir-758 Urinary Bladder Neoplasms Finally, overexpression of NOTCH2 significantly rescued the proliferation, migration and invasion of BC cells transfected with miR +genetics_knock down_promote 30988798 hsa-mir-181a Carcinoma, Endometrioid In addition, rescue experiments demonstrated that inhibition of miR-181a-5p significantly reversed the effect of CCAT1 knockdown on EC cell proliferation and migration. +lncRNA target 30988784 hsa-mir-425 Uterine Cervical Neoplasms 5p inhibited cervical cancer cell growth by targeting AIFM1. +other 30988779 hsa-mir-500 Tuberculosis In conclusion, the present analysis identified hsa-miR-500a-3p and hsa-miR-29a-3p, as well as CDC42, ACTA1, PTEN and FOS, as the most promising biomarkers and therapeutic candidates for LTBI. +other 30988779 hsa-mir-29a Tuberculosis In conclusion, the present analysis identified hsa-miR-500a-3p and hsa-miR-29a-3p, as well as CDC42, ACTA1, PTEN and FOS, as the most promising biomarkers and therapeutic candidates for LTBI. +other 30988779 hsa-mir-500a Tuberculosis In conclusion, the present analysis identified hsa-miR-500a-3p and hsa-miR-29a-3p, as well as CDC42, ACTA1, PTEN and FOS, as the most promising biomarkers and therapeutic candidates for LTBI. +genetics_overexpression_promote 30988777 hsa-mir-634 Pancreatic Carcinoma Notably, the ectopic overexpression of miR-634 in PC cells inhibited tumor progression, whereas miR-634 silencing reversed these effects. +genetics_overexpression_promote 30988774 hsa-mir-638 Osteosarcoma Overexpression of miR-638 induced Bcl-2 associated X and caspase-3 protein expression, and suppressed cyclin D1, phospholipase D1 (PLD1) and vascular endothelial growth factor (VEGF) protein expression in osteosarcoma. +genetics_knock down_promote 30988768 hsa-mir-508 Carcinoma, Renal Cell ZEB1 knockdown exhibited a functional role similar to miR-508 overexpression in ccRCC cells, and restoration of ZEB1 expression significantly reversed the inhibitory effects of miR-508 on the malignant phenotype of ccRCC cells. +lncRNA target 30988764 hsa-mir-552 Osteosarcoma 5p may serve as a new therapeutic target for treatment of patients with osteosarcoma. +lncRNA target 30988756 hsa-mir-21 Osteochondritis Dissecans The results of the current study highlighted that GS-Rb1 could target miR-21 and its target gene, PDCD4, to protect OGD-injured cardiomyocytes. +lncRNA target 30988735 hsa-mir-365a Liver Neoplasms In the current study, it was revealed that lncRNA zinc-finger E-box binding homeobox 1 antisense 1 (ZEB1-AS1) serves as a ceRNA for miR-365a-3p, functioning to positively modulate E2F transcription factor 2 (E2F2) expression in liver cancer cells. EdU staining and flow cytometry analysis indicated that downregulation of ZEB1-AS1 could suppress cell proliferation and decrease the S phase proportion of liver cancer cells, which was effectively reversed by the inhibition of miR-365a-3p. +lncRNA target 30988734 hsa-mir-214 Diabetic Nephropathies Collectively, these data suggest that miR-214 regulates diabetes through a ROS/Akt/mTOR signaling pathway by UCP2 in proximal tubular cells. +circulation_biomarker_diagnosis_ns 30988678 hsa-mir-146a Lymphoma, Large B-Cell, Diffuse The aim of the present study was to compare the expression level of miR-146a in plasma-derived exosomes of responsive DLBCL patients (response to R-CHOP (Rituximab, and Cyclophosphamide, Hydroxydaunorubicin, Oncovine and Prednisone)), refractory DLBCL patients (resistant to R-CHOP), patients receiving R-CHOP, and healthy donors. +genetics_knock down_promote 30988676 hsa-mir-487a Carcinoma, Hepatocellular Overexpression of MIR4435-2HG and miRNA-487a promoted the proliferation of cells of HCC cell lines, and miRNA-487a knockdown partially attenuated the enhancing effects of MIR4435-2HG overexpression on cancer cell proliferation. +genetics_knock down_promote 30988676 hsa-mir-4435-2 Carcinoma, Hepatocellular Overexpression of MIR4435-2HG and miRNA-487a promoted the proliferation of cells of HCC cell lines, and miRNA-487a knockdown partially attenuated the enhancing effects of MIR4435-2HG overexpression on cancer cell proliferation. +lncRNA target 30988663 hsa-mir-26a Osteosarcoma Conclusions: Our findings demonstrated that SNHG6 acted as an oncogene in osteosarcoma cells through regulating miR-26a-5p/ULK1 at a post-transcriptional level. +lncRNA target 30988624 hsa-mir-122 Carcinoma, Hepatocellular CONCLUSION: Collectively, the results of this study revealed that LINC01296 is a tumor promoter that can promote the migration and invasion of HCC cells through EMT, while miR5P is involved in the underlying mechanisms. +genetics_overexpression_promote 30988367 hsa-mir-975 Testicular Diseases However, qPCR assays reveal that CTPSynIsoC and miR-975 overexpression each provokes a differential response in expression of a number of cancer-related genes, indicating that the shared CTPSyn upregulation seen in either case is likely the cause of observed testicular overgrowth. +genetics_knock down_promote 30988277 hsa-mir-196a Carcinoma, Hepatocellular Knockdown of miR-196a or miR-196b suppressed cell proliferation, glycolysis, cell cycle process, colony formation but induced apoptosis or necrosis in HCC cells. +genetics_knock down_promote 30988277 hsa-mir-196b Carcinoma, Hepatocellular Knockdown of miR-196a or miR-196b suppressed cell proliferation, glycolysis, cell cycle process, colony formation but induced apoptosis or necrosis in HCC cells. +genetics_knock down_promote 30988156 hsa-mir-140 Pulmonary Fibrosis Taken together, our findings showed that H19 knockdown attenuated pulmonary fibrosis via the regulatory network of lncRNA H19-miR +circulation_biomarker_diagnosis_ns 30988139 hsa-mir-320c Esophageal Squamous Cell Carcinoma The serum levels of miR5p, miR-320c, miR-638, and miR-92a-3p were significantly higher in patients with ESD than in controls, and this four-miRNA signature could efficiently differentiate patients with ESD from the controls (AUC = 0.842; 95% CI, 0.778-0.893; P < 0.001). +circulation_biomarker_diagnosis_ns 30988139 hsa-mir-638 Esophageal Squamous Cell Carcinoma The serum levels of miR5p, miR-320c, miR-638, and miR-92a-3p were significantly higher in patients with ESD than in controls, and this four-miRNA signature could efficiently differentiate patients with ESD from the controls (AUC = 0.842; 95% CI, 0.778-0.893; P < 0.001). +circulation_biomarker_diagnosis_ns 30988139 hsa-mir-451a Esophageal Squamous Cell Carcinoma RESULTS The serum levels of miR +circulation_biomarker_diagnosis_ns 30988139 hsa-mir-197 Esophageal Squamous Cell Carcinoma RESULTS The serum levels of miR +circulation_biomarker_diagnosis_ns 30988139 hsa-mir-16 Esophageal Squamous Cell Carcinoma RESULTS The serum levels of miR +circulation_biomarker_diagnosis_ns 30988139 hsa-mir-92a Esophageal Squamous Cell Carcinoma RESULTS The serum levels of miR +other 30988132 hsa-mir-106b Diabetes Mellitus Further analysis indicated that miR-106b-5p was up-regulated in AGEs-sEVs and importantly, in exudate-derived sEVs from patients with diabetic foot ulcer. +other 30988132 hsa-mir-106b Diabetic Foot Further analysis indicated that miR-106b-5p was up-regulated in AGEs-sEVs and importantly, in exudate-derived sEVs from patients with diabetic foot ulcer. +other 30988072 hsa-mir-125b Diabetic Retinopathy Neovascularization has been identified as an important clinical property in DR, however, the exact mechanisms in DR neovascularization are still unclear and need further elucidation.Methods: Quantitative real-time PCR (qRT-PCR) was conducted to detect the expression level of long non-coding RNA (lncRNA)-metastasis associated lung adenocarcinoma transcript 1 (MALAT1), miR-125b and vascular endothelial-cadherin (VE-cadherin) in human retina microvascular endothelial cells (hRMECs) treated with high glucose (HG). +genetics_knock down_promote 30988067 hsa-mir-20a Colorectal Neoplasms Flow cytometry showed the MICA protein level is significantly reduced in miR-20a-overexpressing CRC cells and increased in miR-20a knockdown CRC cells. +circulation_biomarker_diagnosis_up 30987831 hsa-mir-663a Osteosarcoma We discovered that miR-663a expressions were remarkably elevated in both tissues and plasmas of OS patients. +lncRNA target 30987676 hsa-mir-143 Intervertebral Disc Degeneration The NP cells isolated from degenerative intervertebral disc (IVD) were introduced with a series of mimic, inhibitor, or AICAR to explore the functional role of miR +genetics_GWAS 30987652 hsa-mir-199b Carcinoma, Non-Small-Cell Lung CONCLUSION: Our findings suggest that mutant K-Ras plays an oncogenic role through downregulating miR-199b in NSCLC and that overexpression of miR-199b is a novel strategy for the treatment of K-Ras-mutated NSCLC. +genetics_overexpression_promote 30987515 hsa-mir-7a Neuralgia Subsequently, miR-7a was overexpressed or silenced in dorsal root ganglion cells to investigate the role of miR-7a in neuropathic pain. +circulation_biomarker_diagnosis_up 30987164 hsa-mir-215 Cancer Pain To test this hypothesis, plasma samples were obtained from 25 patients with cancer pain prior to the initiation of hydromorphone treatment and the circulating miRNA levels were evaluated, focusing on four miRNAs (i.e., hsa-miR +circulation_biomarker_diagnosis_up 30987164 hsa-mir-423 Cancer Pain To test this hypothesis, plasma samples were obtained from 25 patients with cancer pain prior to the initiation of hydromorphone treatment and the circulating miRNA levels were evaluated, focusing on four miRNAs (i.e., hsa-miR +circulation_biomarker_diagnosis_up 30987164 hsa-let-7a Cancer Pain To test this hypothesis, plasma samples were obtained from 25 patients with cancer pain prior to the initiation of hydromorphone treatment and the circulating miRNA levels were evaluated, focusing on four miRNAs (i.e., hsa-miR +circulation_biomarker_diagnosis_up 30987164 hsa-mir-363 Cancer Pain To test this hypothesis, plasma samples were obtained from 25 patients with cancer pain prior to the initiation of hydromorphone treatment and the circulating miRNA levels were evaluated, focusing on four miRNAs (i.e., hsa-miR +circulation_biomarker_diagnosis_up 30987164 hsa-mir-26a Cancer Pain To test this hypothesis, plasma samples were obtained from 25 patients with cancer pain prior to the initiation of hydromorphone treatment and the circulating miRNA levels were evaluated, focusing on four miRNAs (i.e., hsa-miR +circulation_biomarker_diagnosis_up 30987164 hsa-mir-144 Cancer Pain To test this hypothesis, plasma samples were obtained from 25 patients with cancer pain prior to the initiation of hydromorphone treatment and the circulating miRNA levels were evaluated, focusing on four miRNAs (i.e., hsa-miR +circulation_biomarker_diagnosis_up 30987164 hsa-mir-451a Cancer Pain To test this hypothesis, plasma samples were obtained from 25 patients with cancer pain prior to the initiation of hydromorphone treatment and the circulating miRNA levels were evaluated, focusing on four miRNAs (i.e., hsa-miR +circulation_biomarker_diagnosis_up 30987164 hsa-let-7f Cancer Pain To test this hypothesis, plasma samples were obtained from 25 patients with cancer pain prior to the initiation of hydromorphone treatment and the circulating miRNA levels were evaluated, focusing on four miRNAs (i.e., hsa-miR +genetics_overexpression_promote 30986552 hsa-mir-425 Osteosarcoma 5p upregulation strikingly abrogated the activation of Wnt/beta-catenin signaling pathway induced by MALAT1 and TUG1 overexpression in OS cells. +circulation_biomarker_diagnosis_ns 30985893 hsa-mir-15b Infertility We extended our study to azoospermia patients and found that infertile patients have a significantly higher level of miR-15b in semen and plasma samples. +circulation_biomarker_diagnosis_ns 30985893 hsa-mir-15b Aspermia We extended our study to azoospermia patients and found that infertile patients have a significantly higher level of miR-15b in semen and plasma samples. +other 30985693 hsa-mir-20a Colorectal Neoplasms By bioinformatics analysis, 5 DEMs (miR-145, miR-497, miR-30a, miR-31, and miR-20a) and 8 TFs (ELK4 (ETS-family transcription factor), myeloblastosis proto-oncogene like (MYBL)1, MYBL2, CEBPA, PPARA, PPARD, PPARG, and endothelial PAS domain protein (EPAS1)) appeared to be associated with CRC and were therefore used to construct miRNA-TF-gene networks. By qRT-PCR, we demonstrated that miR-20a was significantly upregulated in CRC tissues. +genetics_overexpression_suppress 30984546 hsa-mir-222 Intervertebral Disc Degeneration 3p was significantly higher in IDD tissues than in normal intervertebral disc tissue, and report that overexpression of miR +circulation_biomarker_diagnosis_down 30984518 hsa-mir-135a Autism Spectrum Disorder Finally, the results strongly suggested that dys-regulated serum miRNAs might be involved in molecular pathways associated with ASD and miR +circulation_biomarker_diagnosis_down 30984518 hsa-mir-28 Autism Spectrum Disorder Finally, the results strongly suggested that dys-regulated serum miRNAs might be involved in molecular pathways associated with ASD and miR +lncRNA target 30984249 hsa-mir-99b Urinary Bladder Neoplasms Furthermore, mechanistic analysis and functional assays validated that DLEU1 induced cell proliferation, invasion, and cisplatin resistance of BCA cells by de-repressing the expression of HS3ST3B1 through sponging miR-99b. +circulation_biomarker_diagnosis_up 30984166 hsa-mir-150 Myasthenia Gravis These results revealed that increased serum levels of miR-150 in MG patients could have a functional effect on PBMCs. +genetics_overexpression_promote 30984146 hsa-mir-17 Enterovirus Infections Overexpression of hsa-miR-17 approximately 92 inhibited, while inhibition of endogenous hsa-miR-17 approximately 92 facilitated EV71 replication. +lncRNA target 30983885 hsa-mir-26a Colorectal Neoplasms In this paper, we explored the role of micro-RNA-26a in the regulation of proliferation and migration in CRC-derived cells through the negative regulation of PTEN, a key negative regulator of the AKT pathway. +other 30983818 hsa-mir-24 Stomach Neoplasms 5p expression level in EGC was significantly higher than that in AGC (AUC = 0.791, 95%CI: 0.574-1.000, P = 0.024). +circulation_biomarker_diagnosis_ns 30983818 hsa-mir-4632 Stomach Neoplasms CONCLUSION: The differentially expressed circulatory plasma miR +transcription factor target 30983593 hsa-mir-15b Myocardial Reperfusion Injury CONCLUSIONS Api treatment downregulated the expression of miR-15b and upregulated the expression of JAK2 and the activity of the JAK2-STAT3 pathway, thereby alleviating myocardial I-R injury, cardiomyocyte apoptosis, and ROS production in vitro. +other 30983514 hsa-mir-202 Breast Neoplasms 5p was highly expressed in drug-resistant breast cancer tissues, while PTEN was expressed less. +genetics_GWAS 30983504 hsa-mir-222 Gastrointestinal Stromal Tumors In conclusion, this is the first study investigating the role of SNPs on miR-221/222 precursor sequences and their binding region on KIT 3'UTR in GIST. +genetics_GWAS 30983504 hsa-mir-221 Gastrointestinal Stromal Tumors In conclusion, this is the first study investigating the role of SNPs on miR-221/222 precursor sequences and their binding region on KIT 3'UTR in GIST. +circulation_biomarker_diagnosis_ns 30983306 hsa-mir-1 Celiac Disease The expression pattern of miR-21 and miR-31 was estimated in serum of 25 untreated CD patients (recently diagnosed), 25 treated CD patients (on gluten-free diet) and 20 healthy controls using qRT-PCR. In conclusion, circulating miRNA-21 and miRNA-31 could serve as potential non-invasive biomarkers for pediatric CD patients. +circulation_biomarker_diagnosis_ns 30983306 hsa-mir-21 Celiac Disease The expression pattern of miR-21 and miR-31 was estimated in serum of 25 untreated CD patients (recently diagnosed), 25 treated CD patients (on gluten-free diet) and 20 healthy controls using qRT-PCR. In conclusion, circulating miRNA-21 and miRNA-31 could serve as potential non-invasive biomarkers for pediatric CD patients. +circRNA target 30983072 hsa-mir-132 Urinary Bladder Neoplasms CONCLUSION: In this study, we revealed that circDOCK1 affected the progression of BC via modulation of circDOCK1/hsa-miR +other 30983045 hsa-mir-222 Anovulation These findings suggest that miR-222 and THBS1 play important roles in follicular atresia, ovarian development, and female reproduction. +other 30983035 hsa-mir-185 Alopecia Areata 5p might play important and synergistic roles in the active phase of AA. +other 30983035 hsa-mir-125b Alopecia Areata 5p might play important and synergistic roles in the active phase of AA. +target gene 30982780 hsa-mir-216b Carcinoma, Ductal, Breast PNPO was down-regulated and up-regulated by miR-216b-5p mimics and inhibitors, respectively, in breast cancer cells. +lncRNA target 30982765 hsa-mir-338 Colorectal Neoplasms 5p are mediated by suppression of PIK3C3. +lncRNA target 30982576 hsa-mir-218 Carcinoma, Hepatocellular Taken together, our findings demonstrated that MNX1-AS1 promoted the malignant properties of HCC through targeting miR +genetics_knock down_promote 30982496 hsa-mir-205 Endometrial Neoplasms Knockdown of miR +lncRNA target 30982495 hsa-mir-206 Nasopharyngeal Neoplasms Furthermore, the emphasized tumor-suppressive role of miR-206 in the C666-1 cells indicates that it has the potential to provide a new therapeutic approach for the undifferentiated NPC. +genetics_overexpression_promote 30982494 hsa-mir-152 Breast Neoplasms Overexpression of miR-152 significantly suppressed breast cancer cell proliferation, migration, and invasion. +transcription factor target 30982493 hsa-mir-148 Glioblastoma 3p directly repressed the expression of DNMT1 and inhibited proliferation, migration, and invasion by regulating DNMT1-RUNX3 axis and the epithelial-mesenchymal transition in GBM. +genetics_knock down_promote 30982491 hsa-mir-145 Leukemia, Myeloid Then we performed a RREB1 knockdown assay in NB4 and HL-60 cells; the results showed that knockdown of RREB1 upregulated expression of CD11b, CEBPbeta, and microRNA-145 (miR-145), which hinted that knockdown of RREB1 enhanced granulocytic differentiation of myeloid leukemia cells. These collective findings demonstrated that RREB1 blocks granulocytic differentiation of myeloid leukemia cells by inhibiting the expression of miR-145 and downstream targets of the RAS signal pathway. +genetics_overexpression_promote 30982490 hsa-mir-204 Leukemia, Myeloid, Acute Overexpression of miR-204 potentiated ATO-induced AML cell growth inhibition and apoptosis. +lncRNA target 30982489 hsa-mir-510 Carcinoma, Non-Small-Cell Lung Expression of SRCIN1 was downregulated in lung cancer cells and negatively correlated with miR-510 expression in tumor tissues. These results showed that miR-510 acted as an oncogenic miRNA in NSCLC, partly by targeting SRCIN1, suggesting that miR-510 can be a potential approach for the treatment of patients with malignant lung cancer. +lncRNA target 30982470 hsa-mir-342 Endometriosis METHODS: Primary adipocyte cells cultured from 20 patients with and without endometriosis were transfected with mimics and inhibitors of microRNAs 342-3p or Let 7b-5p to model the status of these microRNAs in endometriosis. +genetics_knock down_suppress 30982352 hsa-mir-632 Carcinoma, Hepatocellular Knockdown of MYCT1 by small interfering RNA partially reversed the effects of miR-632 on HCC cell events. +genetics_knock down_promote 30982057 hsa-mir-641 Carcinoma, Non-Small-Cell Lung RESULTS CRNDE level was upregulated in NSCLC, and its knockdown suppressed NSCLC cells proliferation and enhanced apoptosis, whereas miR-641 antagonized the regulatory effect of CRNDE knockdown by directly binding to CRNDE. +genetics_overexpression_promote 30982052 hsa-mir-21 Chronic Rhinosinusitis With Nasal Polyps In addition, further investigation regarding the reason underlying miR-21 overexpression in CRSwNP could provide a molecular target for novel treatment strategies for nasal polyposis. +lncRNA target 30981984 hsa-mir-145 Retinal Neovascularization Overall, our findings indicate that miR-145 is a novel regulator of TMOD3-dependent cytoskeletal architecture and pathological angiogenesis and a potential target for development of treatments for neovascular eye disorders. +lncRNA target 30981984 hsa-mir-145 Vascular Diseases Overall, our findings indicate that miR-145 is a novel regulator of TMOD3-dependent cytoskeletal architecture and pathological angiogenesis and a potential target for development of treatments for neovascular eye disorders. +lncRNA target 30981984 hsa-mir-145 osteogenesis imperfecta type 1 Moreover, inhibition of TMOD3 promoted EC angiogenic function and pathological neovascularization in OIR and abolished the vascular effects of miR-145 inhibitors in vitro and in vivo. +circulation_biomarker_diagnosis_ns 30981837 hsa-mir-338 Prostatic Neoplasms Mechanism investigation revealed that SNHG15 was located in the cytoplasm of PCa cells and acted as a molecular sponge of microRNA +lncRNA target 30981829 hsa-mir-155 Gaucher Disease Our data demonstrate that neither neuroinflammation nor disease progression in GCase deficiency are dependent on miR-155 and suggest that miR-155 inhibition would not be a promising therapeutic target in Gaucher's disease. +circulation_biomarker_diagnosis_ns 30981817 hsa-mir-21 Pulmonary Disease, Chronic Obstructive As we found in this investigation, COPD patients have higher miR-21 level in total serum EVs. +other 30981758 hsa-mir-539 Carcinoma, Hepatocellular Then, miR-539 down-regulated APOBEC3B and promoted HBV replication. In conclusion, HULC activates HBV by modulating HBx/STAT3/miR-539/APOBEC3B signaling in HBV-related HCC. +genetics_overexpression_promote 30981721 hsa-mir-186 Adenocarcinoma of Lung 5p overexpression-induced LUAD cell phenotype could be partially rescued by co-overexpression of miR +circulation_biomarker_diagnosis_ns 30981701 hsa-let-7a Asthma AIM: Our study was designed to investigate circulating miR-155 and Let-7a expression levels in the plasma of asthmatic children and healthy controls. +genetics_overexpression_suppress 30981205 hsa-mir-204 Carcinoma, Non-Small-Cell Lung Furthermore, we demonstrated that the downregulation of miR-204 expression was responsible for CAV-1 overexpression in these cisplatin-resistant NSCLC cells. We demonstrated that dysregulation of miR-204/caveolin-1 axis is an important mechanism for NSCLC cells to develop the chemoresistance. +lncRNA target 30981105 hsa-mir-218 Pancreatic Carcinoma 5p target in PC cells. +other 30981080 hsa-mir-101 Liver Neoplasms CONCLUSIONS: The discoveries testified that HULC protected ATDC5 cells against TNF-alpha-induced inflammatory injury by repression of miR-101. +lncRNA target 30981077 hsa-mir-23a Periodontitis CONCLUSION: Our study provides novel evidence that miR-23a acts as a negative regulator of osteogenesis in periodontitis patients'PDLSCs and that miR-23a may serve as a biomarker and potential target of periodontitis. +lncRNA target 30980849 hsa-mir-126 Glioblastoma 3p is commonly down-regulated and exerts tumor-suppressive roles in kinds of human cancers, including GBM. +transcription factor target 30980790 hsa-mir-34a Polycystic Ovary Syndrome miR-34a expression was significantly reduced in posterior capsule opacification (PCO) clinical samples. These results demonstrate that miR-34a may act as a suppressor in PCO by regulating human lens epithelial cell proliferation and migration through downregulation of c-Met. +other 30980790 hsa-mir-34a Capsule Opacification miR-34a expression was significantly reduced in posterior capsule opacification (PCO) clinical samples. +circulation_biomarker_diagnosis_ns 30980673 hsa-mir-146a Colorectal Neoplasms miRNA-146a-5p (miR-146a) is the major miRNA in CRCSC exosomes and exosomal miR-146a promotes stem-like properties and tumorigenicity by targeting Numb in recipient CRC cells. Among 53 CRC patients, those with abundant exosomal miR-146a expression in serum exhibits higher miR-146a(High) /Numb(Low) CRCSC traits, an increased number of tumor-filtrating CD66(+) neutrophils and a decreased number of tumor-infiltrating CD8(+) T cells. +other 30980391 hsa-mir-524 Squamous Cell Carcinoma of Head and Neck These results indicated that TUG1 participated in the development of OSCC as a competing endogenous RNA to competitively bind to miR5p and thus mediate DLX1 expression. +lncRNA target 30980388 hsa-mir-506 Laryngeal Neoplasms In vivo assays were performed and we found that DCGR5 depressed stemness of human laryngeal cancer cells through modulating miR-506 and Wnt signaling pathway. Taken these together, we reported that DGCR5 induced CSC-like properties by sponging miR-506 through activating Wnt in human laryngeal carcinoma cells. +other 30980286 hsa-mir-15a Diabetic Retinopathy However, miR-15a could downregulate VEGF and Robo4 to ameliorate DR development. +lncRNA target 30980241 hsa-mir-25 Visceral Hypersensitivity These data suggest that NCI suppresses miRNA5p expression and enhances CCL2 expression, thus contributing to visceral hypersensitivity in adult rats. +genetics_overexpression_promote 30980043 hsa-mir-218 Sexually Transmitted Diseases We find that downregulation of miR-218 in the mPFC increases susceptibility to a single session of social defeat, whereas overexpression of miR-218 selectively in mPFC pyramidal neurons promotes resilience to CSDS and prevents stress-induced morphological alterations to those neurons. +genetics_knock down_suppress 30979827 hsa-mir-653 Breast Neoplasms Knockdown of hsa_circ_0004771 and ZEB2 served as equally authentic of miR-653 mimics to induce growth inhibition and apoptosis in breast cancer cells. +lncRNA target 30979712 hsa-mir-181a Mitochondrial Diseases Altogether, our results demonstrate that miR-181a/b regulate mitochondrial homeostasis and that these miRNAs may be effective gene-independent therapeutic targets for MDs characterized by neuronal degeneration. +lncRNA target 30979712 hsa-mir-181b Mitochondrial Diseases Altogether, our results demonstrate that miR-181a/b regulate mitochondrial homeostasis and that these miRNAs may be effective gene-independent therapeutic targets for MDs characterized by neuronal degeneration. +other 30979011 hsa-mir-21 Esophageal Squamous Cell Carcinoma Collectively, we identified surface biomarkers of stem cells in esophageal squamous cell carcinoma, and discovered thathsa-miR3p may be involved in stemness maintenance by regulating TRAF4. +exosome 30978341 hsa-mir-499a Adenocarcinoma of Lung Among them, miR-499a-5p was upregulated in both highly metastatic lung cancer cell line and their exosomes. +other 30978148 hsa-mir-27a Inflammatory Bowel Diseases Our results suggest the use of miR-27a/191 for Crohn's disease small bowel, none of the five candidate genes for Crohn's disease colon, and miR-16/27a for ulcerative colitis. +other 30978148 hsa-mir-16 Inflammatory Bowel Diseases Our results suggest the use of miR-27a/191 for Crohn's disease small bowel, none of the five candidate genes for Crohn's disease colon, and miR-16/27a for ulcerative colitis. +genetics_overexpression_promote 30977909 hsa-mir-134 Osteosarcoma In conclusion, overexpression of miR-134 suppresses osteosarcoma cell invasion and metastasis through the inhibition of MMP1 and MMP3 expression. +lncRNA target 30977354 hsa-mir-181b Osteosarcoma In summary, our data support a critical role for NF-kappaB-dependent upregulation of miR-181b, which further inhibited PTEN expression and promoted the cell proliferation of OS cell lines. +transcription factor target 30977043 hsa-mir-365 Brain Ischemia We found that miR-365 exacerbated ischemic brain injury and OS-induced neuronal damage and was associated with a reduced expression of OXR1 (Oxidation Resistance 1). In contrast, miR-365 antagomir alleviated both the brain injury and OXR1 reduction. +transcription factor target 30976957 hsa-mir-34a Liver Neoplasms In liver cancer patient tissues, the expression of vascular endothelial growth factor (VEGF)-induced signaling pathways, including phosphorylated VEGF receptor 2 (VEGFR(2)), AKT, and ERK(1/2),were simultaneously elevated, but miR-34a expression was reduced and negatively correlated with SMAD(2) and SMAD(4). All these results demonstrated that Emodin inhibited tumorigenesis in liver cancer by simultaneously inhibiting the VEGFR(2)-AKT-ERK(1/2)signaling pathway and promoting a miR-34a-mediated signaling pathway. +other 30976199 hsa-mir-188 Breast Neoplasms Moreover, miR3p was identified as a novel negative regulator of TMED3 in breast cancer, which can slow down the proliferation, migration and invasion of MCF-7 cells. +other 30976046 hsa-mir-1260b Biliary Tract Neoplasms 5p) associated with recurrence and prognosis of BTC after radical surgery. +other 30976046 hsa-mir-1470 Biliary Tract Neoplasms 5p) associated with recurrence and prognosis of BTC after radical surgery. +other 30976046 hsa-mir-6875 Biliary Tract Neoplasms 5p) associated with recurrence and prognosis of BTC after radical surgery. +other 30976046 hsa-mir-1225 Biliary Tract Neoplasms 5p) associated with recurrence and prognosis of BTC after radical surgery. +other 30976046 hsa-mir-1234 Biliary Tract Neoplasms 5p) associated with recurrence and prognosis of BTC after radical surgery. +lncRNA target 30975733 hsa-mir-153 Autistic Disorder MicroRNA-153 promotes brain-derived neurotrophic factor and hippocampal neuron proliferation to alleviate autism symptoms through inhibition of JAK-STAT pathway by LEPR. Therefore, we evaluate the ability of miR-153 to influence brain-derived neurotrophic factor (BDNF) of autism as well as proliferation and apoptosis of hippocampal neuron through the janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway by targeting leptin receptor (LEPR). +lncRNA target 30975181 hsa-mir-451a Prethrombotic State CONCLUSIONS: In summary, SiNPs could accelerate the vascular endothelial dysfunction and prethrombotic state via miR-451a negative regulating the IL6R/STAT/TF signaling pathway. +transcription factor target 30975094 hsa-mir-10b Carcinoma, Renal Cell Mechanically, miR-10b targets HOXA3 to exert its tumor-suppressive effect on ccRCC in vitro. +lncRNA target 30975029 hsa-mir-17 Adenocarcinoma of Lung Subsequent mechanism experiments showed that circ-MTO1 served as a sponge of oncogenic miR-17 to increase the expression of RNA-binding protein QKI-5, leading to the inactivation of Notch signaling pathway, thereby restraining the growth of LUAD. Taken together, our data suggest that circ-MTO1 is a critical negative regulator of LUAD and elucidate the potential molecular mechanism of a novel circ-MTO1/miR-17/QKI-5 feedback loop in inhibiting LUAD progression. +lncRNA target 30975024 hsa-mir-204 Osteosarcoma Besides, we initially explored Fibronectin-1 (FN1) as the target of LINC00963/miR +other 30974330 hsa-mir-25 Panic Disorder 3p) was positively related to both the changes of PDSS3 scores ( big up tri, openPDSS3) (p = 0.017, 31.5% contribution) and big up tri, open PDSS7 (p = 0.016, 32.3% contribution). +circulation_biomarker_diagnosis_up 30974224 hsa-mir-182 Colorectal Neoplasms miR-182 expression was evidently reduced in postoperative serum samples, compared with preoperative serum samples, whereas miR-182 expression was re-elevated in serum samples from CRC patients who developed postoperative recurrence. +transcription factor target 30974042 hsa-mir-27b Ischemic Stroke Collectively, our data suggest that miR-27b inhibition promotes recovery after ischemic stroke by regulating AMPK activity. +lncRNA target 30973678 hsa-mir-124 Glioma Overall, our finding illuminates that LINC00511 is induced by SP1 and accelerates the glioma progression through targeting miR +other 30973285 hsa-mir-155 Ventricular Premature Complexes Consistent with the up-regulation of Smarca4, the expression of VC associated microRNA such as miR-133b and miR-155 was also increased. +other 30973285 hsa-mir-133b Ventricular Premature Complexes Consistent with the up-regulation of Smarca4, the expression of VC associated microRNA such as miR-133b and miR-155 was also increased. +transcription factor target 30973209 hsa-mir-27b Lichen Planus, Oral Here, we showed that basal epithelium apoptosis was reduced and the miR-27b-3p levels were decreased in clinical OLP samples. Taken together, these data showed that miR-27b-3p regulated keratinocyte apoptosis through cyclophilin D/Bcl2 signalling, suggesting the miR-27b-3p regulated the pathogenesis of OLP. +lncRNA target 30973065 hsa-mir-543 Pituitary Neoplasms Based on the findings, the inhibition of miR-543 was found to play a tumor suppressive role in PA through the down-regulation of Wnt/beta-catenin pathway by negatively regulating Smad7. +genetics_knock down_promote 30972996 hsa-mir-363 Colorectal Neoplasms We observed that MALAT1 was highly expressed in colorectal cancer tissues and cells, and MALAT1 knockdown inhibited cell proliferation as well as expression levels of EZH2 by upregulated miR +genetics_overexpression_promote 30972994 hsa-mir-1178 Nasopharyngeal Carcinoma Overexpression of miR +other 30972742 hsa-mir-1236 Pneumonia, Ventilator-Associated These findings indicated the regulatory association of miR-1236 with TLR4 and the abnormal expression of TLR4 caused by the presence of rs11536889 in the 3'-UTR of mRNA, which interfere with its interaction with the miR-1236, contributing to the risk of VAP. +other 30972742 hsa-mir-1236 Pulmonary Disease, Chronic Obstructive These findings indicated the regulatory association of miR-1236 with TLR4 and the abnormal expression of TLR4 caused by the presence of rs11536889 in the 3'-UTR of mRNA, which interfere with its interaction with the miR-1236, contributing to the risk of VAP. +circulation_biomarker_diagnosis_ns 30972735 hsa-mir-146a Encephalomyelitis, Autoimmune, Experimental However, further work is needed to determine protein levels of CFH and other possible targets of miR-146a in serum and cerebrospinal fluid of MS patients. +lncRNA target 30972208 hsa-mir-125a Fibrosis, Renal Aim of the study was to evaluate the function of miR-125a-3p and its effect on regulation of fibrosis and interleukin (IL)-17 in LN. MiR-125a-3p could be a important factor in the pathogenesis of LN which causes decrease in expression of IL-17 by potentially binding to the 3'UTR region causing suppression of fibrosis via down-regulating TGF-beta1 in the SV40MES13 rat mesangial cells. +lncRNA target 30972208 hsa-mir-125a Lupus Nephritis Aim of the study was to evaluate the function of miR-125a-3p and its effect on regulation of fibrosis and interleukin (IL)-17 in LN. MiR-125a-3p could be a important factor in the pathogenesis of LN which causes decrease in expression of IL-17 by potentially binding to the 3'UTR region causing suppression of fibrosis via down-regulating TGF-beta1 in the SV40MES13 rat mesangial cells. +lncRNA target 30972208 hsa-mir-125a Lupus Erythematosus, Systemic Aim of the study was to evaluate the function of miR-125a-3p and its effect on regulation of fibrosis and interleukin (IL)-17 in LN. MiR-125a-3p could be a important factor in the pathogenesis of LN which causes decrease in expression of IL-17 by potentially binding to the 3'UTR region causing suppression of fibrosis via down-regulating TGF-beta1 in the SV40MES13 rat mesangial cells. +lncRNA target 30972201 hsa-mir-9 Alzheimer Disease Moreover, in the APP miR-9 inhibitor group, neuronal cell differentiation and miR-9 expression were significantly reduced, and treatment with zoanthamine reduced the number of differentiated cells and miR-9 expression compared with the APP miR-9 inhibitor group. +genetics_GWAS 30972198 hsa-let-7 Breast Neoplasms related mirSNPs might be associated with carcinogenesis and clinical outcome in breast cancer, suggesting that variants of miRNA let +circRNA target 30972190 hsa-mir-197 Urinary Bladder Neoplasms In conclusion, our data demonstrated that hsa_circ_0002024 suppresses cell proliferation, migration, and invasion in BC by sponging miR +lncRNA target 30972186 hsa-mir-524 Glioma In addition, we found that NCF2 reintroduction restored the inhibitor effect of miR-524 on glioma progression. +other 30972168 hsa-mir-625 Intervertebral Disc Degeneration Taken together, our results suggest that activation of the TLR4/NF-kappaB signaling pathway induces pro-inflammatory cytokines, which further up-regulates the expression of miR5p, resulting in the down-regulation of COL1A1 and eventually contributing to the pathological process of IDD. +other 30971726 hsa-mir-150 Premature Birth 5p had the strongest ability to predict PTB (AUC = 0.8725) and cervical shortening (AUC = 0.8514). +lncRNA target 30971627 hsa-mir-181c Carcinoma, Endometrioid The potential effects of miR-181c on the apoptosis of E2-induced RL95-2 cells suggest that miR-181c could be an effective target for endometrial carcinoma therapies. +lncRNA target 30971296 hsa-mir-147a Carcinoma, Non-Small-Cell Lung CONCLUSIONS: SNH suppressed metastasis of NSCLC cells and the mechanism may involve with the Linc00668/miR-147a/Slug axis. +genetics_knock down_promote 30970520 hsa-mir-96 Leukemia, Myeloid, Acute In conclusion, MALAT1 knockdown inhibited proliferation, promoted apoptosis and enhanced Ara-C sensitivity in AML cells by upregulating miR-96, providing novel insights into the critical role of MALAT1 as a miRNA sponge in AML. +lncRNA target 30970517 hsa-mir-600 Squamous Cell Carcinoma of Head and Neck In summary, our results demonstrate an explicit oncogenic role of ADAMTS9-AS2 in TSCC tumorigenesis via competition with miR-600, suggesting a new regulatory mechanism of ADAMTS9-AS2 and providing a potential therapeutic target for TSCC patients. +genetics_overexpression_promote 30970507 hsa-mir-18a Atrial Premature Complexes Effects of ectopic GAS5 on inhibiting cell viability and survival & promoting apoptosis and DNA damage were reversed by miR-18a overexpression in PCa cells. +lncRNA target 30970507 hsa-mir-18a Prostatic Neoplasms Our results provide a novel mechanism of alpha-Solanine treatment in human prostate cancer and help to develop a new approach to sensitizing radioresistant prostate cancer cells by targeting GAS5/miR-18a. +circulation_biomarker_diagnosis_up 30970398 hsa-mir-378c Sleep Apnea, Obstructive The purpose of our study was to investigate the expression of atherosclerosis related serum miRNAs in OSA patients.Method: We screened 116 participants including normal controls(n=24), OSA alone(n=32),OSA patients with AS(n=32),and patients with AS but without OSA(n=28).qRT-PCR to analyze the microRNA profile was performed in these subjects.Clinical and blood test with lipid parameters were analysed using Spearman correlations.Result:Compared to normal controls, miRNA-148a-5p, miRNA-378c, miRNA +circulation_biomarker_diagnosis_up 30970398 hsa-mir-127 Atherosclerosis The purpose of our study was to investigate the expression of atherosclerosis related serum miRNAs in OSA patients.Method: We screened 116 participants including normal controls(n=24), OSA alone(n=32),OSA patients with AS(n=32),and patients with AS but without OSA(n=28).qRT-PCR to analyze the microRNA profile was performed in these subjects.Clinical and blood test with lipid parameters were analysed using Spearman correlations.Result:Compared to normal controls, miRNA-148a-5p, miRNA-378c, miRNA +circulation_biomarker_diagnosis_up 30970398 hsa-mir-134 Atherosclerosis The purpose of our study was to investigate the expression of atherosclerosis related serum miRNAs in OSA patients.Method: We screened 116 participants including normal controls(n=24), OSA alone(n=32),OSA patients with AS(n=32),and patients with AS but without OSA(n=28).qRT-PCR to analyze the microRNA profile was performed in these subjects.Clinical and blood test with lipid parameters were analysed using Spearman correlations.Result:Compared to normal controls, miRNA-148a-5p, miRNA-378c, miRNA +circulation_biomarker_diagnosis_up 30970398 hsa-mir-378c Atherosclerosis The purpose of our study was to investigate the expression of atherosclerosis related serum miRNAs in OSA patients.Method: We screened 116 participants including normal controls(n=24), OSA alone(n=32),OSA patients with AS(n=32),and patients with AS but without OSA(n=28).qRT-PCR to analyze the microRNA profile was performed in these subjects.Clinical and blood test with lipid parameters were analysed using Spearman correlations.Result:Compared to normal controls, miRNA-148a-5p, miRNA-378c, miRNA +circulation_biomarker_diagnosis_up 30970398 hsa-mir-127 Sleep Apnea, Obstructive The purpose of our study was to investigate the expression of atherosclerosis related serum miRNAs in OSA patients.Method: We screened 116 participants including normal controls(n=24), OSA alone(n=32),OSA patients with AS(n=32),and patients with AS but without OSA(n=28).qRT-PCR to analyze the microRNA profile was performed in these subjects.Clinical and blood test with lipid parameters were analysed using Spearman correlations.Result:Compared to normal controls, miRNA-148a-5p, miRNA-378c, miRNA +circulation_biomarker_diagnosis_up 30970398 hsa-mir-365a Sleep Apnea, Obstructive The purpose of our study was to investigate the expression of atherosclerosis related serum miRNAs in OSA patients.Method: We screened 116 participants including normal controls(n=24), OSA alone(n=32),OSA patients with AS(n=32),and patients with AS but without OSA(n=28).qRT-PCR to analyze the microRNA profile was performed in these subjects.Clinical and blood test with lipid parameters were analysed using Spearman correlations.Result:Compared to normal controls, miRNA-148a-5p, miRNA-378c, miRNA +circulation_biomarker_diagnosis_up 30970398 hsa-mir-148a Sleep Apnea, Obstructive The purpose of our study was to investigate the expression of atherosclerosis related serum miRNAs in OSA patients.Method: We screened 116 participants including normal controls(n=24), OSA alone(n=32),OSA patients with AS(n=32),and patients with AS but without OSA(n=28).qRT-PCR to analyze the microRNA profile was performed in these subjects.Clinical and blood test with lipid parameters were analysed using Spearman correlations.Result:Compared to normal controls, miRNA-148a-5p, miRNA-378c, miRNA +circulation_biomarker_diagnosis_up 30970398 hsa-mir-365a Atherosclerosis The purpose of our study was to investigate the expression of atherosclerosis related serum miRNAs in OSA patients.Method: We screened 116 participants including normal controls(n=24), OSA alone(n=32),OSA patients with AS(n=32),and patients with AS but without OSA(n=28).qRT-PCR to analyze the microRNA profile was performed in these subjects.Clinical and blood test with lipid parameters were analysed using Spearman correlations.Result:Compared to normal controls, miRNA-148a-5p, miRNA-378c, miRNA +circulation_biomarker_diagnosis_up 30970398 hsa-mir-134 Sleep Apnea, Obstructive The purpose of our study was to investigate the expression of atherosclerosis related serum miRNAs in OSA patients.Method: We screened 116 participants including normal controls(n=24), OSA alone(n=32),OSA patients with AS(n=32),and patients with AS but without OSA(n=28).qRT-PCR to analyze the microRNA profile was performed in these subjects.Clinical and blood test with lipid parameters were analysed using Spearman correlations.Result:Compared to normal controls, miRNA-148a-5p, miRNA-378c, miRNA +circulation_biomarker_diagnosis_up 30970398 hsa-mir-148a Atherosclerosis The purpose of our study was to investigate the expression of atherosclerosis related serum miRNAs in OSA patients.Method: We screened 116 participants including normal controls(n=24), OSA alone(n=32),OSA patients with AS(n=32),and patients with AS but without OSA(n=28).qRT-PCR to analyze the microRNA profile was performed in these subjects.Clinical and blood test with lipid parameters were analysed using Spearman correlations.Result:Compared to normal controls, miRNA-148a-5p, miRNA-378c, miRNA +genetics_knock down_promote 30970294 hsa-mir-142 Lung Neoplasms 3p up-regulation, as well as the knockdown of either beta-catenin or MALAT1 significantly reduced the tumorigenesis of NSCLC cells. +genetics_overexpression_promote 30970220 hsa-mir-4458 Breast Neoplasms Additionally, PI3K/AKT and ERK were shown to be inhibited by miR-4458 overexpression in BC cells. +circulation_biomarker_diagnosis_ns 30970081 hsa-mir-441 Pre-Eclampsia This decrease is also mimicked in the plasma levels at both early and late weeks of pregnancy, highlighting that miR-441 levels can serve as a diagnostic marker of risk of preeclampsia in pregnant women. +genetics_overexpression_promote 30970081 hsa-mir-376c Pre-Eclampsia Overexpression of the miR-441, as well as miR-376c, promoted cell viability, migration, and invasion in the human immortalized cytotrophoblast cell line HTR8/SVneo, indicating that their decrease in pregnant women would result in anomalous apoptosis and functional imbalance resulting in premature abortion and other complications. +circulation_biomarker_prognosis_ns 30969094 hsa-mir-497 Cerebral Infarction, Acute In addition, miR-497 in the serum has the potential to be a prognostic and diagnostic marker of ACI and a therapeutic target. +circulation_biomarker_prognosis_ns 30969093 hsa-mir-142 Uterine Cervical Neoplasms CONCLUSIONS: In summary, serum miR-3142 in cervical cancer is increased and is closely related to the occurrence and development of cervical cancer, which can be used as a diagnostic and prognostic marker of cervical cancer. +circulation_biomarker_diagnosis_down 30969085 hsa-mir-625 Liver Cirrhosis METHODS: miR-625 and miR-920 expressions were analyzed in the plasma of 40 patients with liver cirrhosis and 41 healthy controls. +genetics_overexpression_promote 30969075 hsa-mir-22 Breast Neoplasms In ad-dition, overexpression of miR-22 significantly decreased the migration of MCF-7 cells, validating the tumor suppressor role of miR-22 in breast cancer cells. +circulation_biomarker_diagnosis_up 30969074 hsa-mir-24 Prostatic Neoplasms RESULTS The expression of miR-324 in prostate cancer group was significantly higher than that in the BPH group and normal control group (all p < 0.01). CONCLUSIONS The increased expression of serum miR-324 in patients with prostate cancer may be a potential new biomarker for the diagnosis of prostate cancer, which is helpful for the differentiation between PC and BPH. +lncRNA target 30968966 hsa-mir-34a Enterovirus B, Human The above-mentioned phenomenon was reversed by a miR-34a inhibitor after CVB3 infection. +lncRNA target 30968775 hsa-mir-205 Carcinoma, Non-Small-Cell Lung 3p inhibitor inhibited the migration and invasion of NCIH1975 cell and restrained TGF-beta-induced EMT in NSCLC cells. +lncRNA target 30968775 hsa-mir-30 Carcinoma, Non-Small-Cell Lung 3p inhibitor inhibited the migration and invasion of NCIH1975 cell and restrained TGF-beta-induced EMT in NSCLC cells. +exosome 30968694 hsa-mir-155 Osteoporosis Blockage of BMMs miR-155 levels reversed the suppression by EC-Exos of osteoclast induction, confirming that exosomal miR-155 may have therapeutic potential against osteoporosis. +transcription factor target 30968343 hsa-mir-124 Parkinson Disease Using the correlation between miRNA expression and the abundance of their known targets, miR3p, miR-19a-3p, miR-27b-3p, and miR-29c-3p were identified as key regulators altered in MSA, mainly contributing to neuroinflammation. +transcription factor target 30968343 hsa-mir-124 Multiple System Atrophy Using the correlation between miRNA expression and the abundance of their known targets, miR3p, miR-19a-3p, miR-27b-3p, and miR-29c-3p were identified as key regulators altered in MSA, mainly contributing to neuroinflammation. +transcription factor target 30968343 hsa-mir-27b Multiple System Atrophy Using the correlation between miRNA expression and the abundance of their known targets, miR3p, miR-19a-3p, miR-27b-3p, and miR-29c-3p were identified as key regulators altered in MSA, mainly contributing to neuroinflammation. +transcription factor target 30968343 hsa-mir-19a Parkinson Disease Using the correlation between miRNA expression and the abundance of their known targets, miR3p, miR-19a-3p, miR-27b-3p, and miR-29c-3p were identified as key regulators altered in MSA, mainly contributing to neuroinflammation. +transcription factor target 30968343 hsa-mir-19a Multiple System Atrophy Using the correlation between miRNA expression and the abundance of their known targets, miR3p, miR-19a-3p, miR-27b-3p, and miR-29c-3p were identified as key regulators altered in MSA, mainly contributing to neuroinflammation. +transcription factor target 30968343 hsa-mir-27b Parkinson Disease Using the correlation between miRNA expression and the abundance of their known targets, miR3p, miR-19a-3p, miR-27b-3p, and miR-29c-3p were identified as key regulators altered in MSA, mainly contributing to neuroinflammation. +lncRNA target 30968145 hsa-mir-34a Colorectal Neoplasms Furthermore, western blotting demonstrated that miR34a mimics inhibited the epithelialmesenchymal transition (EMT) process of CRCs, while the miR34a inhibitor had the opposite effect. +circulation_biomarker_diagnosis_ns 30967899 hsa-mir-122 Hepatitis B To identify the role of miR-122 in NA therapy, 80 CHB patients with high viral load (HVL) were enrolled and serum miR-122 levels at baseline, week 12 and week 24 were measured. In conclusion, we identified the dynamic change of serum miR-122 level and miR-122 levels at week 12 and week 24 as independent predictors for VR in CHB patients with HVL treated with NAs. +genetics_overexpression_promote 30967746 hsa-mir-21 Pterygium CONCLUSIONS: Aberrant miR-21 overexpression in the pterygium could target PTEN, which contributes to abnormal proliferation of the HPF cells through depressing the PTEN/AKT pathway. +genetics_overexpression_promote 30967746 hsa-mir-21 Hypocalciuric hypercalcemia, familial, type 1 CONCLUSIONS: Aberrant miR-21 overexpression in the pterygium could target PTEN, which contributes to abnormal proliferation of the HPF cells through depressing the PTEN/AKT pathway. +transcription factor target 30967627 hsa-mir-186 Breast Neoplasms 3p/EREG axis orchestrates tamoxifen resistance and aerobic glycolysis in ER-positive breast cancer, suggesting targeting miR +transcription factor target 30967591 hsa-mir-155 Diabetes Mellitus Topical miR-155 inhibition targets both excessive inflammation and impaired re-epithelization and remodeling, being a potentially new and effective treatment for chronic diabetic foot ulcers. +transcription factor target 30967591 hsa-mir-155 Wounds and Injuries Topical miR-155 inhibition targets both excessive inflammation and impaired re-epithelization and remodeling, being a potentially new and effective treatment for chronic diabetic foot ulcers. +lncRNA target 30967527 hsa-mir-29b Multiple Myeloma Silencing of MIAT inhibited MM cell growth and sensitized MM cells to BTZ by negatively regulating miR-29b. +genetics_knock down_promote 30967394 hsa-mir-155 Lymphoma, Large B-Cell, Diffuse Ectopic upregulation of miR-155 sensitized germinal-center B-cell-like (GCB)-DLBCL cell lines to vincristine, and consistently, reduction and knockout of miR-155 induced vincristine resistance, documenting that miR-155 functionally induces vincristine sensitivity. +transcription factor target 30967300 hsa-mir-152 Carcinoma, Hepatocellular 3p exhibited an antineoplastic activity via targeting CDK8 and might be served as a potential therapeutic target for the treatment of HCC. +genetics_overexpression_promote 30967276 hsa-mir-29b Cardiomyopathies Combination of circHIPK3 silencing and miR-29b-3p overexpression had a stronger effect on cardiac fibrosis suppression in vivo than did circHIPK3 silencing or miR-29b-3p overexpression alone. CONCLUSIONS: Our data suggest that circHIPK3 serves as a miR-29b-3p sponge to regulate CF proliferation, migration and development of cardiac fibrosis, revealing a potential new target for the prevention of Ang II-induced cardiac fibrosis. +circulation_biomarker_diagnosis_up 30967271 hsa-mir-612 Cholangiocarcinoma Besides, LINC01061 existing in the cytoplasm of CCA cells interacted with miR-612. To sum up, our present exploration demonstrated that LINC01061 sponges miR-612 so as to upregulate SEMA4D expression for the progression of CCA, suggesting an optional promising and effective target for the therapy of patients with CCA. +lncRNA target 30967266 hsa-mir-619 Carcinoma, Squamous Cell, Cutaneous 5p was validated to act as a tumor suppressor in CSCC through retarding cell proliferation and cisplatin resistance. +other 30967263 hsa-mir-1247 Carcinoma, Squamous Cell, Cutaneous 5p. +other 30967263 hsa-mir-1238 Carcinoma, Squamous Cell, Cutaneous 5p. +genetics_overexpression_promote 30966836 hsa-mir-516a Carcinoma, Non-Small-Cell Lung Overexpression of HIST3H2A reversed the anti-proliferation effects induced by miR-516a-5p and acted as an independent prognostic factor of poor survival in patients with NSCLC. +lncRNA target 30965609 hsa-mir-9 Colorectal Neoplasms Furthermore, microRNA-9 (miR-9) has a tumor-suppressive function in CRC. In this study, we used an HG concentration to activate miR-9 downregulation in CRC cells. +other 30965334 hsa-mir-210 Hypersensitivity We speculate that miRNA-210 could be important in MC sensitization that leads to allergic symptoms. +genetics_overexpression_promote 30965236 hsa-mir-1236 Ovarian Neoplasms 3p into circ-CSPP1 overexpressing OC cells. +transcription factor target 30965092 hsa-mir-15b Leukemia, Promyelocytic, Acute Moreover, we identified CCNE1 as a direct target of miR-15b, and demonstrated that CCNE1 was involved in cell differentiation and proliferation in acute promyelocytic leukemia cells. In addition, we demonstrated a novel pathway in which miR-15b regulated cells arrested in the G0/G1 phase and promoted terminal differentiation of cells by targeting CCNE1, which could modulate the cell cycle effort pRb in APL cells. +exosome 30964699 hsa-mir-224 Femur Head Necrosis Down-regulation of exosomal microRNA3p derived from bone marrow-derived mesenchymal stem cells potentiates angiogenesis in traumatic osteonecrosis of the femoral head. +other 30964391 hsa-mir-294 Cardiomyopathies OBJECTIVE: To determine whether transient reintroduction of embryonic stem cell cycle miR-294 promotes cardiomyocyte cell cycle reentry enhancing cardiac repair after myocardial injury. +lncRNA target 30964182 hsa-mir-210 Brain Ischemia CONCLUSIONS: Our data indicate that miRNA-210 expression is upregulated in the rats with global cerebral ischemia, and the rise of miRNA-210 level increases the apoptosis of neuronal cells through the activation of HIF-1alpha-VEGF signaling pathway. +transcription factor target 30964181 hsa-mir-378a Cholestasis The down-regulated hsa-miR-378a-5p may cause a protective alteration through up-regulating MDR3 expression in cholestasis. +lncRNA target 30964179 hsa-mir-26a Respiratory Distress Syndrome, Newborn CONCLUSIONS MiR-26a can affect inflammatory responses and markers through the Wnt/-catenin signaling pathway in neonatal rats with RDS. +lncRNA target 30964173 hsa-mir-216a Breast Neoplasms CONCLUSIONS: We showed that miR-216a-5p played a role as antioncogene in BC, which provides a new therapeutic target for the treatment of BC. +genetics_overexpression_promote 30964171 hsa-mir-630 Thyroid Cancer, Papillary Overexpression of miR-630 inhibited PTC cell proliferation and induced cell apoptosis via suppressing the expression of caspase-3 and caspase-6. +genetics_overexpression_promote 30964170 hsa-mir-153 Carcinoma, Non-Small-Cell Lung The overexpression of miRNA +genetics_overexpression_promote 30964169 hsa-mir-345 Carcinoma, Non-Small-Cell Lung Results of transwell assays showed that miR-345 overexpression could dramatically inhibit NSCLC cell migration and invasion. +genetics_knock down_promote 30964168 hsa-mir-4301 Squamous Cell Carcinoma of Head and Neck In addition, after LACAT1 knockdown model was constructed using lentivirus and transfected into OSCC cell lines, cell cloning assay and flow cytometry were used to analyze the impact of LACAT1 on biological functions of OSCC cells, and finally its association with microRNA-4301 was explored. +lncRNA target 30964167 hsa-mir-3174 Rectal Neoplasms CONCLUSIONS: Our study elucidated that miR-3174 functioned as an oncogene in rectal cancer by targeting PCBD2, which might bring new insights into the search for novel biomarkers and therapeutic strategies. +transcription factor target 30964165 hsa-mir-335 Urinary Bladder Neoplasms CRKL was verified as a specific target of miR-335 in BC cells and the relationship between CRKL and miR-335 expression was negatively correlated in BC tissues. +genetics_overexpression_promote 30964163 hsa-let-7b Uterine Cervical Neoplasms Over-expressed HOST2 reduced let-7b expression, promoted proliferation migration and invasion and inhibited the apoptosis of CaSki and HeLa cells; however, silencing HOST2 or overexpressing let-7b enhanced the expression of let-7b, inhibited proliferation migration and invasion, and promoted the apoptosis of CaSki and HeLa cells, and let-7b mimic could reverse the promoting effect of HOST2 on the growth of CC cells. +lncRNA target 30964161 hsa-mir-539 Carcinoma, Ovarian Epithelial 3p/SPARCL1 axis, as a target for the treatment of EOC, might become a feasible and new method of tumor treatment. +genetics_overexpression_promote 30964158 hsa-mir-129 Ovarian Neoplasms The SOX4 overexpression was further confirmed to reverse the inhibitory effects of miRNA-129 on proliferative and migratory abilities of OC cells. +lncRNA target 30964156 hsa-mir-214 Spinal Cord Injuries 5p inhibitor retarded inflammatory diffusion by inhibiting inflammatory factors and chemokines after SCI. +lncRNA target 30964156 hsa-mir-214 Nerve Degeneration 5p inhibitor retarded inflammatory diffusion by inhibiting inflammatory factors and chemokines after SCI. +circulation_biomarker_diagnosis_up 30964155 hsa-mir-29b Diabetes, Gestational Moreover, miR-29b mimics significantly lowered the blood glucose level in rats with GDM (p<0.05). +lncRNA target 30964106 hsa-mir-1224 Carcinoma, Hepatocellular 5p expression may decrease proliferation, induce apoptosis, inhibit migration and invasion, and suppress tube formation in TECs of human HCC. +genetics_knock down_promote 30963785 hsa-mir-29c Carcinoma, Hepatocellular Rescue experiments revealed that miR-29c inhibitor could partially counteract the impact induced by HOXA-AS3 knockdown in HCC. +transcription factor target 30963631 hsa-mir-103a-2 Prostatic Neoplasms 5p/AR-V7 axis modulating the cell proliferation of AR-positive prostate cancer cells via AR downstream targets. +other 30963571 hsa-mir-150 Carcinoma, Hepatocellular Hence, we constructed a hsa-mir5p-centric ceRNA network and two effective nomogram prognostic models, and the related RNAs may be useful as potential biomarkers for predicting recurrence in patients with HCC. +genetics_GWAS 30963551 hsa-mir-146a Breast Neoplasms The miR-146a rs2910164 polymorphism was genotyped in 300 BC cases and 300 age- and gender-matched healthy controls using T-ARMS-PCR. +lncRNA target 30962766 hsa-mir-665 Colorectal Neoplasms CONCLUSIONS: Breast cancer anti-estrogen resistance 4 promotes the CRC cells stemness through targeting to miR-665/STAT3 signaling and identification of the BCAR4 in CRC stem cells provides a new insight into CRC diagnosis, treatment, prognosis and next-step translational investigations. +transcription factor target 30962718 hsa-mir-875 Prostatic Neoplasms 3p targeted the 3'-untranslated region of PF4V1 and derepressed the inhibitory function of PF4V1 in PCa (P<0.05). +genetics_overexpression_suppress 30962696 hsa-mir-1 Carcinoma, Hepatocellular Overexpression of miR +other 30962265 hsa-mir-200a Colorectal Neoplasms MiR-200a-3p was inversely correlated with SNHG16 expression in CRC tissues. +genetics_overexpression_promote 30962263 hsa-mir-140 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Overexpression of miR +other 30962170 hsa-mir-200c Carcinoma, Hepatocellular In conclusion, our results suggest that the miR-200c expression was significantly down-regulated and associated with poor prognosis in HCC. +other 30961699 hsa-mir-31 Carcinoma, Hepatocellular 3p down-regulated E2F1 to promote cell proliferation and migration in HCC. +other 30961681 hsa-mir-205 Pituitary Neoplasms 5p expression was declined in pituitary cell lines compared with normal cell line. +genetics_knock down_suppress 30961650 hsa-mir-188 Head and Neck Neoplasms CONCLUSIONS: Our findings revealed that CAF-derived exosomes contain lower miR-3188 levels than NFs, and the loss of miR-3188 in exosomes contributes to the malignant phenotypes of HNC cells through the derepression of BCL2. +lncRNA target 30959863 hsa-let-7g Colonic Neoplasms Our results further supported the inhibitory effects of let-7g on CRC cell migration, invasion and extracellular calcium influx through store-operated calcium channels. +circulation_biomarker_diagnosis_up 30959814 hsa-mir-423 Diabetes Mellitus, Type 2 Plasma miR +transcription factor target 30959742 hsa-mir-143 Stomach Neoplasms The expression level of miR-143 was down-regulated in GC cell lines, including HER2-positive GC cell lines, MKN7, and KATO-III. Furthermore, syn-miR-143 indirectly down-regulated the expression of HER2, an upstream molecule of KRAS, through silencing DEAD/H-box RNA helicase 6 (DDX6), RNA helicase, which enhanced HER2 protein expression at the translational step in HER2-positive GC cells. +genetics_knock down_promote 30959202 hsa-mir-9 Sarcoma, Synovial METHODS: Overexpression or knockdown of miR-9 in human synovial sarcoma (HSS) cell lines was carried out by miR-9 mimics or miR-9 inhibitors transfection. +other 30958910 hsa-mir-28 Prostatic Neoplasms 3p, miR-374, miR-376c, miR-202, miR-128a, and miR-185 in high-grade compared to low-grade prostate cancer cases at biopsy, after adjusting for age (P < 0.05). +other 30958910 hsa-mir-374 Prostatic Neoplasms 3p, miR-374, miR-376c, miR-202, miR-128a, and miR-185 in high-grade compared to low-grade prostate cancer cases at biopsy, after adjusting for age (P < 0.05). +other 30958910 hsa-mir-376c Prostatic Neoplasms 3p, miR-374, miR-376c, miR-202, miR-128a, and miR-185 in high-grade compared to low-grade prostate cancer cases at biopsy, after adjusting for age (P < 0.05). +other 30958910 hsa-mir-128a Prostatic Neoplasms 3p, miR-374, miR-376c, miR-202, miR-128a, and miR-185 in high-grade compared to low-grade prostate cancer cases at biopsy, after adjusting for age (P < 0.05). +other 30958910 hsa-mir-100 Prostatic Neoplasms 3p, miR-374, miR-376c, miR-202, miR-128a, and miR-185 in high-grade compared to low-grade prostate cancer cases at biopsy, after adjusting for age (P < 0.05). +other 30958910 hsa-mir-942 Prostatic Neoplasms 3p, miR-374, miR-376c, miR-202, miR-128a, and miR-185 in high-grade compared to low-grade prostate cancer cases at biopsy, after adjusting for age (P < 0.05). +other 30958910 hsa-mir-202 Prostatic Neoplasms 3p, miR-374, miR-376c, miR-202, miR-128a, and miR-185 in high-grade compared to low-grade prostate cancer cases at biopsy, after adjusting for age (P < 0.05). +other 30958882 hsa-let-7a Choriocarcinoma Collectively, our data indicate that beta-catenin/LIN28B/Let-7a pathway may be crucial for the regulation of cell proliferation in human choriocarcinoma cells. +other 30958798 hsa-mir-142 Sepsis In the absence of miR-142, DCs fail to switch from OXPHOS and show reduced production of proinflammatory cytokines and the ability to activate T cells in vitro and in in vivo models of sepsis and alloimmunity. +circulation_biomarker_diagnosis_down 30958621 hsa-mir-377 Osteolysis To investigate the underlying role of miR-377 in wear particle-induced osteolysis (PIO), blood samples from patients undergoing arthroplasty were collected for analyzing the correlation between miR-377 expression and the clinicopathological parameters of PIO. +transcription factor target 30958604 hsa-mir-19b Holt-Oram syndrome In conclusion, our results suggested that miR-19b-3p may be a promising target in inhibiting PDGFRalpha(+) muscle cell osteogenic differentiation and treatment of HO. +lncRNA target 30958603 hsa-let-7b Carcinoma, Squamous Cell Let-7b-5p inhibits proliferation and motility in squamous cell carcinoma cells through negative modulation of KIAA1377. Collectively, our data demonstrated that let-7b-5p can directly but negatively regulate KIAA1377 in SCC cell lines, Ecal109, and HeLa cells. +transcription factor target 30958584 hsa-mir-122 Diabetes Mellitus We first found that the miR-122 level was upregulated in the liver of rats fed with a high-fat diet and injected with streptozotocin (T2D rats), while the expression level of insulin-like growth factor 1 receptor (IGF-1R), a potential target of miR-122, was downregulated in the diabetic liver. An increase of miR-122 level and a decrease of IGF-IR level were observed in IR hepatic cells, which was the same as that in the diabetic liver. +transcription factor target 30958584 hsa-mir-122 Diabetes Mellitus, Type 2 We first found that the miR-122 level was upregulated in the liver of rats fed with a high-fat diet and injected with streptozotocin (T2D rats), while the expression level of insulin-like growth factor 1 receptor (IGF-1R), a potential target of miR-122, was downregulated in the diabetic liver. +lncRNA target 30958584 hsa-mir-122 Insulin Resistance In addition, the PI3K/Akt pathway was deactivated in IR cells, and then reactivated with miR-122 inhibitor transfection. +transcription factor target 30958584 hsa-mir-122 Liver Diseases We first found that the miR-122 level was upregulated in the liver of rats fed with a high-fat diet and injected with streptozotocin (T2D rats), while the expression level of insulin-like growth factor 1 receptor (IGF-1R), a potential target of miR-122, was downregulated in the diabetic liver. An increase of miR-122 level and a decrease of IGF-IR level were observed in IR hepatic cells, which was the same as that in the diabetic liver. +lncRNA target 30957556 hsa-mir-16 Lung Neoplasms 5p can protect LPS-induced A549 cell injury, and its mechanism may be related to the targeted regulation of CXCR3, which could provide a new target for targeted therapy of lung cancer. +lncRNA target 30957187 hsa-mir-27b Bloom Syndrome In conclusion, the findings of the current provide evidence that miR27b3p and miR607 have an oncosuppressive function in PC3 cells and cooperatively downregulate BLM expression at the posttranscriptional level. +other 30957187 hsa-mir-338 Bloom Syndrome Therefore, the current study screened for miRNAs that regulate BLM gene expression, with software predicting that miRNA (miR)27b3p, miR607, miR3613p, miR6285p and miR3383p. +lncRNA target 30957187 hsa-mir-607 Bloom Syndrome In conclusion, the findings of the current provide evidence that miR27b3p and miR607 have an oncosuppressive function in PC3 cells and cooperatively downregulate BLM expression at the posttranscriptional level. +other 30957187 hsa-mir-361 Bloom Syndrome Therefore, the current study screened for miRNAs that regulate BLM gene expression, with software predicting that miRNA (miR)27b3p, miR607, miR3613p, miR6285p and miR3383p. +lncRNA target 30957181 hsa-mir-15a Femur Head Necrosis In conclusion, the present results indicated that miRNA15a5p was involved in the regulation of the apoptosis of BMSCs through regulating the Wnt/betacatenin/PPARgamma signaling pathway, which may serve an important role in the regulation of FHN. +lncRNA target 30957179 hsa-mir-210 Ovarian Neoplasms Taken together, these results suggest that miR2103p may act as a tumor suppressor in ovarian cancer cells and affect the sensitivity of cells to cisplatin by directly targeting E2F3. +other 30957098 hsa-mir-29b Hepatitis C We sought to determine if the baseline hepatic levels of miR-122, miR-29b, Claudin, Occludin, Protein Kinase R (PKR) or PKR activator (PRKRA) were correlated with HCV RNA or stage of fibrosis in patients with chronic hepatitis C (CHC). Conclusion: Our results highlight miR-29b and CLDN as novel predictors of advanced stage of liver fibrosis and baseline HCV RNA in CHC. +other 30957098 hsa-mir-122 Hepatitis C We sought to determine if the baseline hepatic levels of miR-122, miR-29b, Claudin, Occludin, Protein Kinase R (PKR) or PKR activator (PRKRA) were correlated with HCV RNA or stage of fibrosis in patients with chronic hepatitis C (CHC). +lncRNA target 30956986 hsa-mir-194 Keloid 3p and RUNX2 may become new targets for the prevention and treatment of keloids. +lncRNA target 30955870 hsa-mir-214 Renal Insufficiency, Chronic Together, these results demonstrate a pathogenic role of miR-214 in CKD through the disruption of mitochondrial oxidative phosphorylation, and suggest the potential for miR-214 to serve as a therapeutic target and diagnostic biomarker for CKD. +epigenetics 30955437 hsa-mir-93 Uterine Cervical Diseases A miRNA classifier consisting of miR-149, miR-20a, and miR-93 achieved an area under the curve (AUC) of 0.834 for CIN3 detection, which was not significantly different to that of FAM19A4 methylation (AUC: 0.862, p = 0.591). +epigenetics 30955437 hsa-mir-149 Uterine Cervical Diseases A miRNA classifier consisting of miR-149, miR-20a, and miR-93 achieved an area under the curve (AUC) of 0.834 for CIN3 detection, which was not significantly different to that of FAM19A4 methylation (AUC: 0.862, p = 0.591). +epigenetics 30955437 hsa-mir-20a Uterine Cervical Diseases A miRNA classifier consisting of miR-149, miR-20a, and miR-93 achieved an area under the curve (AUC) of 0.834 for CIN3 detection, which was not significantly different to that of FAM19A4 methylation (AUC: 0.862, p = 0.591). +transcription factor target 30955355 hsa-mir-205c Breast Neoplasms These findings demonstrated that the co-nanodelivery of Cur and Chr through targeting miR-132 and miR-205c might be a novel strategy for the treatment of breast cancer. +lncRNA target 30955235 hsa-mir-31 Carcinoma, Non-Small-Cell Lung 3p suppresses EMT, migratory capacity, and metastatic ability by targeting ErbB2 and VAV2 through the Rac1/PAK1/beta-catenin axis in NSCLC. +transcription factor target 30955173 hsa-mir-100 Carcinoma, Ductal, Breast The present work provides further evidence for the role of CXCR-7 in breast cancer and proposes the elimination of inhibitory effects of miR-100 on CXCR-7 expression as a mechanism for its up-regulation in breast cancer tissues. +other 30954901 hsa-mir-21 Carcinoma Taken together, our results suggest that either IR or DSBR-deficient can lead to an upregulation of miR-21 levels and that miR-21 is associated with IR-induced cell growth in soft agar. +lncRNA target 30954590 hsa-mir-335 Osteosarcoma Restoration of SNIP1 expression attenuated the suppressive effect of miR-335 on OS cells. +genetics_knock down_promote 30954576 hsa-mir-629 Carcinoma, Hepatocellular 5p knockdown reduced these parameters. +other 30954221 hsa-mir-1304 Carcinoma, Non-Small-Cell Lung 5p/PPDPF/MACC1 signaling was essential for the development and progression of NSCLC. +other 30953675 hsa-mir-34b Ovarian Neoplasms We conclude that miR200 family members, miR34b and miR203a might be promising complementary biomarkers in ovarian cancer. +other 30953675 hsa-mir-203a Ovarian Neoplasms We conclude that miR200 family members, miR34b and miR203a might be promising complementary biomarkers in ovarian cancer. +genetics_GWAS 30953094 hsa-mir-504 Carcinoma, Non-Small-Cell Lung We found significant associations between the expression of circulating miR-504 and EGFR-activating mutations in NSCLC patients regardless of the normalisation approach used (p=0.0072 and 0.0236 for miR-16 and miR-191 normalisation, respectively). +genetics_overexpression_promote 30952937 hsa-let-7g Carcinoma, Ovarian Epithelial The ectopic overexpression of let-7g in OVCAR3 and HEY-A8 EOC cells induced i) a down-regulation of c-Myc and cyclin-D2 thus promoting cell cycle arrest, ii) a reduction of Vimentin, Snail and Slug thus counteracting the progression of epithelial to mesenchymal transition, iii) a chemosensitization to cis-platinum treatment. +other 30952636 hsa-mir-1 Colorectal Neoplasms miR3p scores were similar when pretreatment biopsies were compared with treatment-naive archival tissues (often primary colorectal cancer). +circulation_biomarker_diagnosis_up 30952494 hsa-mir-449a Diabetes Mellitus Decreased body weight, serum insulin and nitrogen oxide level, and miR-449a were observed in the diabetic group (P < 0.01 for insulin; P < 0.001 for others). +other 30952010 hsa-mir-146a Inflammation Among the changed miRNAs, miR-146a-5p, which is a pulp inflammation-related miRNA, demonstrated the most noticeably altered expression. +lncRNA target 30951952 hsa-mir-889 Osteosarcoma 3p could promote the proliferation of osteosarcoma through inhibiting MNDA expression, which provides a potential therapeutic strategy in treatment for osteosarcoma. +genetics_overexpression_promote 30951946 hsa-mir-384 Prostatic Neoplasms MiR-384 overexpression suppressed CAP in vitro and in vivo development, possibly via acting through its downstream target gene of HOXB7. +other 30951849 hsa-mir-155 Alzheimer Disease Curcumin also reduced levels of miR-155, a micro-RNA reported to drive a neurodegenerative microglial phenotype. +transcription factor target 30951775 hsa-mir-203a Bone Diseases Thus, identification of the role of miR-203a-5p via TGF-beta1 and MMP13 in bone remodeling indicated its potential as a biomarker or therapeutic agent for treating bone and bone-related diseases. +other 30951563 hsa-mir-4717 Colorectal Neoplasms The results suggest that miR-4474 and miR-4717 are up-regulated in CRC tissues in response to F. +genetics_overexpression_promote 30951518 hsa-mir-561 Distal arthrogryposis type 2B Additionally, overexpression of miR-561 rescued the SH-SY5Y proliferation deficiency induced by hsa_circ_0002468 overexpression and abolished the SH-SY5Y differentiation promoted by hsa_circ_0002468. +other 30951202 hsa-mir-212 Stomach Neoplasms Pseudogene GBAP1 contributes to the development and progression of GC by sequestering the miR3p from binding to GBA. +other 30950648 hsa-mir-210 Adenocarcinoma of Lung Moreover, miR3p appears to be a promising biomarker for diagnosis of lung AC. +other 30950328 hsa-mir-203a Brain Injuries, Traumatic 5p) for TBI patients versus healthy controls. +other 30950328 hsa-mir-6236 Brain Injuries, Traumatic 5p) for TBI patients versus healthy controls. +other 30950328 hsa-mir-150 Brain Injuries, Traumatic 5p) for TBI patients versus healthy controls. +other 30950328 hsa-mir-219a-2 Brain Injuries, Traumatic 5p) for TBI patients versus healthy controls. +other 30950328 hsa-mir-488 Brain Injuries, Traumatic 5p) for TBI patients versus healthy controls. +other 30950328 hsa-mir-22 Brain Injuries, Traumatic 5p) for TBI patients versus healthy controls. +other 30950328 hsa-mir-669c Brain Injuries, Traumatic 5p) for TBI patients versus healthy controls. +other 30950328 hsa-mir-9 Brain Injuries, Traumatic 5p) for TBI patients versus healthy controls. +other 30950328 hsa-mir-203b Brain Injuries, Traumatic 5p) for TBI patients versus healthy controls. +transcription factor target 30950326 hsa-mir-125b Triple Negative Breast Neoplasms CONCLUSION: Inhibiting miR-125b regulates the Wnt/beta-catenin pathway and EMT to suppress the proliferation and migration of MDA-MB-468 TNBC cells. +genetics_knock down_promote 30950325 hsa-mir-384 Aicardi-Goutieres syndrome 5 5p in young BMSCs inhibited osteogenic differentiation and accelerated senescence, whereas knockdown of miR +genetics_knock down_suppress 30950325 hsa-mir-384 Osteoporosis 5p may be a therapeutic strategy against age-related bone loss. +circulation_biomarker_diagnosis_up 30949910 hsa-mir-762 Graves Disease CONCLUSIONS: We first demonstrated that aberrant levels of plasmic miR +other 30949905 hsa-mir-139 Carcinoma, Hepatocellular Besides, PARPBP DNA copy gain and miR5p downregulation were associated with PARPBP upregulation in HCC. +genetics_knock down_promote 30949866 hsa-mir-182 Squamous Cell Carcinoma of Head and Neck Loss-of function together with luciferase reporter assay were used to verify the miR +lncRNA target 30949812 hsa-mir-548m Hepatitis C Hence, this study aimed at further investigating the potential impact of EGCG on HCV entry through regulation of the expression of tetraspanin receptor CD81 by the novel predicted miR-548m. +transcription factor target 30949498 hsa-mir-15a Osteoarthritis RESULTS: The expression of PTHrP was upregulated in the OA chondrocytes, whilst miR-15a-5p was downregulated in the OA chondrocytes. CONCLUSIONS: miR-15a-5p promotes the degeneration of chondrocytes by targeting PTHrP and, in addition to helping us understand the development of OA, may be a potential biomarker of OA. +genetics_overexpression_promote 30949413 hsa-mir-205 Breast Neoplasms Overexpression of miR-205 reduced the bone metastasis of MCF7/TG2-C277S cells that express transamidase-activity deficient TG2 and inhibits the invasiveness of MDA-MB-231 breast cancer cells that express TG2. +transcription factor target 30949412 hsa-mir-124 Breast Neoplasms Overall, we provide new insight into the mechanisms by which miR-124 inhibits BC progression, suggesting the potential of miR-124 and MGAT5 as biomarkers for early diagnosis of breast cancer to provide innovative ideas and methods for the diagnosis and treatment of BC. +other 30949400 hsa-mir-202 Azoospermia, Nonobstructive This study revealed that lncRNA Gm2044 and miR-202 were significantly increased in non-obstructive azoospermia of spermatogonial arrest. +other 30949400 hsa-mir-202 Arrest of spermatogenesis This study revealed that lncRNA Gm2044 and miR-202 were significantly increased in non-obstructive azoospermia of spermatogonial arrest. +lncRNA target 30949400 hsa-mir-202 Carcinoma, Embryonal Furthermore, the miRRbfox2 signalling pathway was shown to mediate the suppressive effects of lncRNA Gm2044 on the proliferation of human testicular embryonic carcinoma cells. +lncRNA target 30949394 hsa-mir-15b Diabetes Mellitus Our findings established PPARalpha-responsive miR-15b as a critical regulator of hepatic insulin signaling, thus serving as a new potential therapeutic target for diabetes. +genetics_knock down_promote 30949340 hsa-mir-342 Pancreatic Carcinoma CONCLUSIONS: LncRNA SNHG7 was overexpressed in PC tissues, and knockdown of SNHG7 suppressed PC cell proliferation, migration and invasion via miR3p/ID4 axis. +transcription factor target 30948333 hsa-mir-194 Carcinoma, Hepatocellular Additionally, miR-194 elevation and PRC1 silencing could suppress EMT, growth, proliferation, invasion, and migration in HCC cells by inactivating Wnt/beta-catenin signaling pathway. +lncRNA target 30947960 hsa-mir-210 Spinal Cord Injuries The current data suggest that over-expression of miR-210 may target PTP1B and plays a neuroprotective role on rats after ASCI. +genetics_knock down_promote 30947518 hsa-mir-214 Myocardial Infarction CONCLUSIONS: Loss of superenhancer-regulated circNfix promotes cardiac regenerative repair and functional recovery after myocardial infarction by suppressing Ybx1 ubiquitin-dependent degradation and increasing miR-214 activity and thus may be a promising strategy for improving the prognosis after MI. +transcription factor target 30947018 hsa-mir-199a Pre-Eclampsia CONCLUSION: Our data demonstrated the role of miR-199a-5p in the preeclampsia, and proved that miR-199a-5p could act as a potential therapeutic target for the treatment of PE. +lncRNA target 30947016 hsa-mir-223 Brain Injuries Up-regulation of miR-223 alleviated convulsion attack and improved learning and memory ability, while inhibiting pathological injury of hippocampal neurons and inflammatory injury in FS rats. +lncRNA target 30947016 hsa-mir-223 Seizures, Febrile Up-regulation of miR-223 alleviated convulsion attack and improved learning and memory ability, while inhibiting pathological injury of hippocampal neurons and inflammatory injury in FS rats. +lncRNA target 30946881 hsa-mir-93 Diabetic Nephropathies 5p may be a potential therapeutic target for inhibiting fibrosis and reducing drug resistance in prolactinoma cells. +lncRNA target 30946881 hsa-mir-93 Prolactinoma 5p may be a potential therapeutic target for inhibiting fibrosis and reducing drug resistance in prolactinoma cells. +circulation_biomarker_diagnosis_ns 30945700 hsa-mir-150 Myasthenia Gravis CONCLUSION: Upregulation of miR150-5p is involved in generalized myasthenia gravis patients and is associated with decreased serum levels of IL-17 as well as increased serum levels of IL-10. +other 30945573 hsa-mir-27a Osteoarthritis Therefore, we demonstrated that FOXD2-AS1 could play a crucial role in the progression of OA, at least partially, by regulating miR-27a-3p/TLR4 axis. +circRNA target 30945557 hsa-mir-637 Ovarian Neoplasms Altogether, hsa_circ_0051240 promotes OC cell proliferation, migration and invasion through inhibiting the miR-637/KLK4 axis. +lncRNA target 30945457 hsa-mir-338 Colorectal Neoplasms In conclusion SNHG15 promotes cell proliferation through SNHG15/miR3p/FOS-RAB14 axis in CRC. +genetics_overexpression_promote 30945448 hsa-mir-193b Liver Cirrhosis We conclude that miR-193a/b-3p overexpression attenuates liver fibrosis through suppressing the proliferation and activation of HSCs. +other 30945380 hsa-mir-155 Carcinoma, Hepatocellular The underlying mechanism was explored by quantitative real-time polymerase chain reaction of miRNA (miR5p and miR-26b-5p), luciferase reporter assay, western blotting of Wnt signaling pathway-related proteins (beta-catenin, adenomatous polyposis coli (APC), glycogen synthase kinase 3beta (GSK3beta), ZEB1, and E-cadherin), mitogen-activated protein kinase (MAPK) signaling pathway-related proteins (extracellular signal-regulated kinase [ERK]1/2, p-ERK1/2, c-Jun N-terminal kinase (JNK), p-JNK, P38, and p-P38), and immunofluorescence staining of beta-catenin. +other 30945380 hsa-mir-26b Carcinoma, Hepatocellular The underlying mechanism was explored by quantitative real-time polymerase chain reaction of miRNA (miR5p and miR-26b-5p), luciferase reporter assay, western blotting of Wnt signaling pathway-related proteins (beta-catenin, adenomatous polyposis coli (APC), glycogen synthase kinase 3beta (GSK3beta), ZEB1, and E-cadherin), mitogen-activated protein kinase (MAPK) signaling pathway-related proteins (extracellular signal-regulated kinase [ERK]1/2, p-ERK1/2, c-Jun N-terminal kinase (JNK), p-JNK, P38, and p-P38), and immunofluorescence staining of beta-catenin. +genetics_overexpression_promote 30945380 hsa-mir-143 Carcinoma, Hepatocellular Overexpression of miR143HG suppressed HCC cell proliferation and metastasis, and induced cell cycle arrest and apoptosis. +circulation_biomarker_diagnosis_ns 30945348 hsa-mir-182 Peptic Ulcer Our findings conclude that lnRNA H19, miR-204, and miR-182 may function as novel prospective plasma biomarkers to detect GC and its progression from H. +circulation_biomarker_diagnosis_ns 30945348 hsa-mir-182 Stomach Neoplasms Our findings conclude that lnRNA H19, miR-204, and miR-182 may function as novel prospective plasma biomarkers to detect GC and its progression from H. +circulation_biomarker_diagnosis_ns 30945348 hsa-mir-204 Peptic Ulcer Our findings conclude that lnRNA H19, miR-204, and miR-182 may function as novel prospective plasma biomarkers to detect GC and its progression from H. +circulation_biomarker_diagnosis_ns 30945348 hsa-mir-204 Stomach Neoplasms Our findings conclude that lnRNA H19, miR-204, and miR-182 may function as novel prospective plasma biomarkers to detect GC and its progression from H. +lncRNA target 30945295 hsa-mir-194 Intervertebral Disc Degeneration 5p contributes to the pathogenesis of IDD, which may aid in the development of new therapeutic approaches for IDD by directly targeting miR +lncRNA target 30945294 hsa-mir-381 Triple Negative Breast Neoplasms Therefore, miR-381 is a regulator of Wnt signaling and its re-expression provides a potentially effective strategy for inhibition of TNBC. +transcription factor target 30945144 hsa-mir-744 Spindle Cell Oncocytomas Earlier reports showed downregulated TCA cycle in SCO which is extended by our results adding the role of miR5p targeting ACO2. +genetics_GWAS 30944658 hsa-mir-34 Colorectal Neoplasms Accordingly, the present study investigated the correlation between the methylation status of miR-34 miRNAs and miR-34 expression in paired CRC tumor and normal tissues. In conclusion, it was determined that miR-34 promoter methylation and TP53 polymorphisms may be associated with CRC pathogenesis. +genetics_GWAS 30944658 hsa-mir-34a Colorectal Neoplasms Accordingly, the present study investigated the correlation between the methylation status of miR-34 miRNAs and miR-34 expression in paired CRC tumor and normal tissues. In conclusion, it was determined that miR-34 promoter methylation and TP53 polymorphisms may be associated with CRC pathogenesis. +other 30944648 hsa-mir-425 Pancreatic Carcinoma 5p and IL-23 may be involved in the pathological development of pancreatic cancer. +lncRNA target 30944639 hsa-mir-371a Rectal Neoplasms miR-371a-3p may be a candidate miRNA for CRT sensitivity in LARC via the thiamine metabolism pathway. +other 30944634 hsa-mir-26b Ovarian Neoplasms miR-26b is under-expressed in the ovary and has a close relationship with pathological stage, differentiation degree, and lymph node metastasis of ovarian cancer, which indicates that miR-26b is involved in the occurrence and development of ovarian cancer and is expected to be an effective indicator for treatment and diagnosis of ovarian cancer and the prognosis of patients. +lncRNA target 30944624 hsa-mir-200c Prostatic Neoplasms Effect of miRNA-200c (miR-200c) on the proliferation, invasion and apoptosis of prostate cancer cell line LNCaP was investigated. The low expression of miR-200c is beneficial to inhibit the proliferation and invasion of LNCaP cells in vitro and to promote apoptosis, which may be a potential target for prostate cancer biotherapy. +lncRNA target 30944375 hsa-mir-148a Liver Neoplasms Our analysis revealed HCSC important hubs as candidate regulators for targeting hepatic cancer stemness such as, miR-148a, miR-214, E2F family, MYC and SLC7A5. +lncRNA target 30944375 hsa-mir-214 Liver Neoplasms Our analysis revealed HCSC important hubs as candidate regulators for targeting hepatic cancer stemness such as, miR-148a, miR-214, E2F family, MYC and SLC7A5. +transcription factor target 30944308 hsa-mir-133a Nasopharyngeal Carcinoma Our study is the first to demonstrate that VPS33B is negatively regulated by LMP-1 and nicotine and thus suppresses the proliferation of NPC cells by interacting with NESG1 to regulate EGFR/PI3K/AKT/c-Myc/P53/miR-133a-3p signaling in NPC cells. +lncRNA target 30944299 hsa-mir-155 Pancreatitis These findings demonstrate that the inhibition of miR-155 holds promise for limiting pancreatitis. +genetics_knock down_promote 30944169 hsa-mir-204 Osteoarthritis Here, we identify miR-204 as a markedly up-regulated microRNA in OA cartilage. Ectopic expression of miR-204 in joints triggers spontaneous cartilage loss and OA development, whereas miR-204 inhibition ameliorates experimental OA, with concomitant recovery of PG synthesis and suppression of inflammatory senescence-associated secretory phenotype (SASP) factors in cartilage. +circRNA target 30944081 hsa-mir-634 Squamous Cell Carcinoma of Head and Neck Molecular mechanism demonstrated that hsa_circ_0001742 could directly bind to miR-634, which mediated the functions of hsa_circ_0001742 in TSCC tumorigenesis. Thus, our study showed that hsa_circ_0001742 could promote TSCC progression by targeting miR-634/RAB1A pathway. +lncRNA target 30944080 hsa-mir-196 Stomach Neoplasms The interaction of miR-3196 and ADPGK-AS1 or KDM1B was confirmed by RIP, RNA pull down and luciferase reporter assay.Materials and Methods RESULTS: ADPGK-AS1 was increased in GC tissues and cell lines. The suppressive effect of ADPGK-AS1 silence on GC progression was abolished by KDM1B upregulation.Results CONCLUSIONS: We unveiled that ADPGK-AS1 could promote GC progression via sponging miR-3196 and therefore upregulating KDM1B, providing a novel prognostic biomarker and therapeutic target for GC patients. +lncRNA target 30944042 hsa-mir-204 Medulloblastoma Treatment with HDAC inhibitors resulted in upregulation of miR-204 expression in medulloblastoma cells, suggesting therapeutic role for these inhibitors in the treatment of medulloblastomas. +genetics_knock down_promote 30944041 hsa-mir-663 Ovarian Neoplasms Finally, the expression of TUSC2 was inversely associated with the level of miR-663 in ovarian carcinoma tissue and over-expression of TUSC2 inhibited the migration and invasion abilities of SKOV3 that was promoted by miR-663. +other 30943745 hsa-mir-376b Stomach Neoplasms LncRNA TTN-AS1 contributes to gastric cancer progression by acting as a competing endogenous RNA of miR-376b-3p. +lncRNA target 30943320 hsa-mir-140 Carcinoma, Hepatocellular 5p/TGFBR1/EMT regulatory network may be a valuable target for the development of novel diagnostic and treatment methods for HCC. +genetics_knock down_promote 30943053 hsa-mir-365b Carcinoma, Hepatocellular Furthermore, SGTB was found to be a downstream target of miR-365b, and knockdown of the SGTB gene could mimic the effect of miR-365b in hastening HCC cell migration and invasion. +genetics_overexpression_promote 30943047 hsa-mir-33a Stomach Neoplasms This study suggests that miR-33a inhibited EMT, invasion, and metastasis of GC through the Snail/Slug signaling pathway by modulating SNAI2 expression.NEW & NOTEWORTHY miR-33a targets and inhibits the expression of SNAI2, overexpression of SNAI2 activates the Snail/Slug signaling pathway, the Snail/Slug signaling pathway promotes GC cell proliferation, invasion, and metastasis, and overexpression of miR-33a inhibits cell proliferation, invasion, and metastasis. +epigenetics 30942957 hsa-mir-520c Adenocarcinoma of Lung Taken together, our results reveal methylation/YY1/miR-520c-3p/AKT1/AKT2 as a molecular axis with a potent biological function and highlight miR-520c-3p as a novel potent tumor suppressor in LUAD. +other 30942467 hsa-mir-103b Adenoviridae Infections As a result, the identified miRNAs (namely, miR450a5pmiR103a3p and miR103b5pmiR985p) from 59 samples were considered as potential diagnostic biomarkers in adenovirusinfected children. +other 30942467 hsa-mir-103a Pneumonia As a result, the identified miRNAs (namely, miR450a5pmiR103a3p and miR103b5pmiR985p) from 59 samples were considered as potential diagnostic biomarkers in adenovirusinfected children. +other 30942467 hsa-mir-450a Pneumonia As a result, the identified miRNAs (namely, miR450a5pmiR103a3p and miR103b5pmiR985p) from 59 samples were considered as potential diagnostic biomarkers in adenovirusinfected children. +other 30942467 hsa-mir-450a Adenoviridae Infections As a result, the identified miRNAs (namely, miR450a5pmiR103a3p and miR103b5pmiR985p) from 59 samples were considered as potential diagnostic biomarkers in adenovirusinfected children. +other 30942467 hsa-mir-103b Pneumonia As a result, the identified miRNAs (namely, miR450a5pmiR103a3p and miR103b5pmiR985p) from 59 samples were considered as potential diagnostic biomarkers in adenovirusinfected children. +other 30942467 hsa-mir-98 Pneumonia As a result, the identified miRNAs (namely, miR450a5pmiR103a3p and miR103b5pmiR985p) from 59 samples were considered as potential diagnostic biomarkers in adenovirusinfected children. +other 30942467 hsa-mir-98 Adenoviridae Infections As a result, the identified miRNAs (namely, miR450a5pmiR103a3p and miR103b5pmiR985p) from 59 samples were considered as potential diagnostic biomarkers in adenovirusinfected children. +other 30942467 hsa-mir-103a Adenoviridae Infections As a result, the identified miRNAs (namely, miR450a5pmiR103a3p and miR103b5pmiR985p) from 59 samples were considered as potential diagnostic biomarkers in adenovirusinfected children. +other 30942450 hsa-mir-16 Asthma These results identified that miR16 may be used as a predictive biomarker of therapeutic response in asthma. +lncRNA target 30942447 hsa-mir-195 Osteoarthritis In conclusion, the results indicated that the miR1955p inhibitor served a protective role in OA by inhibiting chondrocyte apoptosis and inflammatory responses by regulating the Wnt/catenin and NFB signaling pathways. +transcription factor target 30942441 hsa-mir-146a Cartilage Diseases The mRNA and protein levels of key factors involved in cartilage degeneration were measured following manipulation of the expression levels of miR146a5p in OA chondrocytes. These data reveal that TN14003 upregulates miR146a5p expression, and also pinpoints a novel role of miR146a5p in inhibiting cartilage degeneration by directly targeting the SDF1/CXCR4 axis. +transcription factor target 30942440 hsa-mir-223 Urinary Bladder Neoplasms The aim of this study was to investigate the functional roles of miR223 and to identify its targets in BC. +transcription factor target 30942440 hsa-mir-223 bladder urothelial carcinoma The aim of this study was to investigate the functional roles of miR223 and to identify its targets in BC. +other 30942430 hsa-mir-99a Bulimia Nervosa The current study investigated microRNAs (miRNA or miR) expression profiles with an emphasis on the role of miR99a5p in BITCtreated BC cells. In addition, the induction of miR99a5p decreased IGF1R, mTOR and FGFR3 expression in BITCtreated BC cells. +circulation_biomarker_diagnosis_ns 30942424 hsa-mir-34c Mesothelioma, Malignant On the whole, the findings of this study indicate that miR34b/c methylation in circulating DNA is a promising biomarker for the prediction of disease progression in patients with MPM. +circulation_biomarker_diagnosis_ns 30942424 hsa-mir-34b Mesothelioma, Malignant On the whole, the findings of this study indicate that miR34b/c methylation in circulating DNA is a promising biomarker for the prediction of disease progression in patients with MPM. +transcription factor target 30942423 hsa-mir-161 Crohn Disease The miR161/HSP70 pathway had a substantial role in the inhibitory effects of TPL on migration, proliferation and ECM synthesis rate of fibroblasts from strictured anastomosis tissues. +lncRNA target 30942417 hsa-mir-214 Triple Negative Breast Neoplasms These findings suggested that miR214 targeting alpha1AT may be a potential mechanism underlying TNBC development. +genetics_overexpression_promote 30942397 hsa-mir-25 Colonic Neoplasms Overexpression of miR25 increased cell viability and migration, decreased apoptosis, decreased caspase3/9 activity level in addition to decreased Bax protein expression, and increased cyclin D1 protein expression in colon cancer cells. +lncRNA target 30941987 hsa-mir-195 Laryngeal Neoplasms MiRNA-195 may serve as a potential molecular target for the treatment and prognosis evaluation of laryngeal carcinoma. +genetics_knock down_promote 30941980 hsa-mir-122 Carcinoma, Non-Small-Cell Lung 5p is overexpressed in NSCLC. +genetics_overexpression_promote 30941977 hsa-mir-140 Prostatic Neoplasms SOX4 expression was inhibited by microRNA-140 overexpression in PCa cells. +lncRNA target 30941968 hsa-mir-5692a Carcinoma, Hepatocellular CONCLUSIONS: This study revealed that miR-5692a had an oncogenic role in HCC by targeting HOXD8 which might bring a novel insight into new therapeutic targets and biomarkers in HCC. +transcription factor target 30941952 hsa-mir-200c Breast Neoplasms CONCLUSIONS: The results of this study indicated that miR-200c might serve as a new target in the diagnosis and treatment of breast cancer. +genetics_GWAS 30941921 hsa-mir-17 Colorectal Neoplasms CONCLUSION: In conclusion, this study indicated that the polymorphisms of MIR17HG were associated with colorectal cancer risk. +lncRNA target 30941802 hsa-mir-124a Arthritis, Rheumatoid We found that miR-124a suppressed the viability and proliferation of RAFLS and increased the percentage of cells in the G1 phase. In conclusion, miR-124a inhibits the proliferation and inflammation in RAFLS via targeting PIK3/NF-kappaB pathway. +lncRNA target 30941771 hsa-mir-524 Thyroid Cancer, Papillary 5p targeting on FOXE1 and ITGA3 prevents thyroid cancer progression through different pathways including cell cycling and autophagy. +other 30941422 hsa-mir-145 Metabolic Diseases Increasing miR-145 may be a new potential therapeutic strategy in preventing and treating metabolic diseases such as type 2 diabetes and atherosclerosis. +other 30941417 hsa-mir-122 Hepatitis C Hepatitis C virus (HCV) is a positive-sense RNA virus that interacts with the liver-specific microRNA, miR-122. +other 30941233 hsa-mir-654 Carcinoma, Ductal, Breast 5p is significantly upregulated DCIS patients having poor prognosis and may be essential for local and distant recurrence in DCIS. +lncRNA target 30940879 hsa-mir-495 Osteoarthritis Taken together, the results of the current study demonstrated that inhibition of miR-495 suppressed chondrocyte apoptosis and promoted its proliferation through activation of the NF-kappaB signaling pathway by up-regulation of CCL4 in OA. +genetics_knock down_promote 30940834 hsa-mir-1 Hypertrophy There was no difference in muscle weight with hypertrophy or atrophy between WT and KO groups; however, even with the significant loss of Dicer expression, myomiR (miR-1, -133a and -206) expression was only reduced by 38% on average. +genetics_knock down_promote 30940834 hsa-mir-1 Atrophy There was no difference in muscle weight with hypertrophy or atrophy between WT and KO groups; however, even with the significant loss of Dicer expression, myomiR (miR-1, -133a and -206) expression was only reduced by 38% on average. +genetics_overexpression_promote 30940776 hsa-mir-204 Prostatic Neoplasms Mechanistically, UCA1 overexpression permitted activation of CXCR4 oncogenes through inhibition of miR-204 activity, as evidenced by the positive association of these two genes with UCA1 levels and inverse correlation with miR-204 expression in PCa tissues. +lncRNA target 30940319 hsa-mir-371 Carcinoma, Hepatocellular Our study demonstrates that miR-371 promotes proliferation and metastasis in HCC by targeting PTEN. +lncRNA target 30940310 hsa-mir-2861 Endometriosis Our study reveals that miR-2861 was lowly expressed in endometriotic tissues, and downregulation of miR-2861 may promote proliferation and inhibit apoptosis of ectopic endometrial cells in endometriosis via upregulation of STAT3 and MMP2. +genetics_overexpression_promote 30940308 hsa-mir-758 Thyroid Cancer, Papillary Overexpression of miR +transcription factor target 30940289 hsa-mir-183 Carcinoma, Hepatocellular In addition, miR-21/181b/183 was upregulated in the HCC liver, and the elevation of these miRNAs could be alleviated by both GSE and sorafenib. PTEN/TIMP3/PDCD4 downregulation was consistent with the targets of miR-21/181b/183 in the HCC liver, and the alteration of these target genes was restored by both GSE and sorafenib. +transcription factor target 30940289 hsa-mir-181b Carcinoma, Hepatocellular In addition, miR-21/181b/183 was upregulated in the HCC liver, and the elevation of these miRNAs could be alleviated by both GSE and sorafenib. PTEN/TIMP3/PDCD4 downregulation was consistent with the targets of miR-21/181b/183 in the HCC liver, and the alteration of these target genes was restored by both GSE and sorafenib. +transcription factor target 30940289 hsa-mir-21 Carcinoma, Hepatocellular In addition, miR-21/181b/183 was upregulated in the HCC liver, and the elevation of these miRNAs could be alleviated by both GSE and sorafenib. PTEN/TIMP3/PDCD4 downregulation was consistent with the targets of miR-21/181b/183 in the HCC liver, and the alteration of these target genes was restored by both GSE and sorafenib. +lncRNA target 30940151 hsa-mir-203a Osteosarcoma CONCLUSIONS: CircTADA2A functions as a tumor promoter in OS to increase malignant tumor behavior through the miR-203a-3p/CREB3 axis, which could be a novel target for OS therapy. +circulation_biomarker_diagnosis_up 30939476 hsa-mir-496 Obesity METHODS: Based on real-time PCR and enzyme-linked immunosorbent assay, mTOR gene and protein expression as well as miR-496 expression were monitored in peripheral blood mononuclear cells (PBMC) from T2DM patients (median age: 71) and healthy age- and BMI matched controls (median age: 69). +circulation_biomarker_diagnosis_up 30939476 hsa-mir-496 Diabetes Mellitus, Type 2 METHODS: Based on real-time PCR and enzyme-linked immunosorbent assay, mTOR gene and protein expression as well as miR-496 expression were monitored in peripheral blood mononuclear cells (PBMC) from T2DM patients (median age: 71) and healthy age- and BMI matched controls (median age: 69). +genetics_overexpression_promote 30939216 hsa-mir-145 Urinary Bladder Neoplasms Overexpression of circCEP128 promoted bladder cancer progression through modulating miR +lncRNA target 30939038 hsa-mir-2116 Breast Neoplasms Rescue assays demonstrated that LINC01433 promoted BC cellular process via regulating miR +transcription factor target 30938885 hsa-mir-214 Liver Failure, Acute The present study aims to inquire whether miR-214 affects therapeutic potential of BMSCs transplantation by targeting PIM-1 in ALF. +genetics_knock down_suppress 30938104 hsa-mir-204 Colorectal Neoplasms Taken together, we demonstrate that the abnormal PCAT6 overexpression inhibits miR-204 expression in CRC, thereby promoting HMGA2/PI3K signaling activity, ultimately enhancing the chemoresistance of CRC cells to 5-FU; PCAT6 represents a promising target for dealing with CRC chemoresistance. +lncRNA target 30938061 hsa-mir-122 Breast Neoplasms Our data indicate that up-regulation of miR-122 promotes cell survival in acquired radioresistant breast cancer and also suggest that miR-122 differentially controls the response to radiotherapy by a dual function as a tumor suppressor an and oncomiR dependent on cell phenotype. +genetics_overexpression_promote 30937952 hsa-mir-199a Uterine Cervical Neoplasms We found that miR-199a-5p was upregulated in cervical carcinoma tissues and cell lines, and overexpression of miR-199a-5p promoted cell proliferation and metastasis in cervical carcinoma. +lncRNA target 30937907 hsa-mir-181b Diabetic Nephropathies This study aimed to study the roleof microRNA (miR)-181b and its target TIMP3 in the development of diabetic nephropathy (DMN) via inhibiting the apoptosis of mesangial cells. +genetics_knock down_promote 30937906 hsa-mir-335 Carcinoma, Hepatocellular The knockdown of miR-335, or overexpression of c-Met, all remarkably abolished the proapoptotic effect of NEAT1 knockdown in HCC cells. +transcription factor target 30937183 hsa-mir-181c Uterine Cervical Neoplasms "miR-181c expression was downregulated only among the episomal CaCx cases and negatively correlated with protein coding transcript of the proliferative target gene, CKS1B of the significantly enriched ""G2/M DNA Damage Checkpoint Regulation"" pathway among CaCx cases." +other 30937183 hsa-mir-143 Uterine Cervical Neoplasms miRNA expression profiles also differed among CaCx cases compared with controls (upregulation-miR-21, miR-16, miR-205, miR-323; downregulation-miR-143, miR-196b, miR-203, miR-34a; progressive upregulation-miR-21 and progressive downregulation-miR-143, miR-34a, miR-196b and miR-203) in the order of HPV-negative controls, HPV16-positive non-malignant samples and HPV16-positive CaCx cases. +other 30937183 hsa-mir-34a Uterine Cervical Neoplasms miRNA expression profiles also differed among CaCx cases compared with controls (upregulation-miR-21, miR-16, miR-205, miR-323; downregulation-miR-143, miR-196b, miR-203, miR-34a; progressive upregulation-miR-21 and progressive downregulation-miR-143, miR-34a, miR-196b and miR-203) in the order of HPV-negative controls, HPV16-positive non-malignant samples and HPV16-positive CaCx cases. +other 30937183 hsa-mir-203 Uterine Cervical Neoplasms miRNA expression profiles also differed among CaCx cases compared with controls (upregulation-miR-21, miR-16, miR-205, miR-323; downregulation-miR-143, miR-196b, miR-203, miR-34a; progressive upregulation-miR-21 and progressive downregulation-miR-143, miR-34a, miR-196b and miR-203) in the order of HPV-negative controls, HPV16-positive non-malignant samples and HPV16-positive CaCx cases. +other 30937183 hsa-mir-196b Uterine Cervical Neoplasms miRNA expression profiles also differed among CaCx cases compared with controls (upregulation-miR-21, miR-16, miR-205, miR-323; downregulation-miR-143, miR-196b, miR-203, miR-34a; progressive upregulation-miR-21 and progressive downregulation-miR-143, miR-34a, miR-196b and miR-203) in the order of HPV-negative controls, HPV16-positive non-malignant samples and HPV16-positive CaCx cases. +other 30937183 hsa-mir-205 Uterine Cervical Neoplasms miRNA expression profiles also differed among CaCx cases compared with controls (upregulation-miR-21, miR-16, miR-205, miR-323; downregulation-miR-143, miR-196b, miR-203, miR-34a; progressive upregulation-miR-21 and progressive downregulation-miR-143, miR-34a, miR-196b and miR-203) in the order of HPV-negative controls, HPV16-positive non-malignant samples and HPV16-positive CaCx cases. +other 30937183 hsa-mir-21 Uterine Cervical Neoplasms miRNA expression profiles also differed among CaCx cases compared with controls (upregulation-miR-21, miR-16, miR-205, miR-323; downregulation-miR-143, miR-196b, miR-203, miR-34a; progressive upregulation-miR-21 and progressive downregulation-miR-143, miR-34a, miR-196b and miR-203) in the order of HPV-negative controls, HPV16-positive non-malignant samples and HPV16-positive CaCx cases. +other 30937183 hsa-mir-16 Uterine Cervical Neoplasms miRNA expression profiles also differed among CaCx cases compared with controls (upregulation-miR-21, miR-16, miR-205, miR-323; downregulation-miR-143, miR-196b, miR-203, miR-34a; progressive upregulation-miR-21 and progressive downregulation-miR-143, miR-34a, miR-196b and miR-203) in the order of HPV-negative controls, HPV16-positive non-malignant samples and HPV16-positive CaCx cases. +other 30937183 hsa-mir-23 Uterine Cervical Neoplasms miRNA expression profiles also differed among CaCx cases compared with controls (upregulation-miR-21, miR-16, miR-205, miR-323; downregulation-miR-143, miR-196b, miR-203, miR-34a; progressive upregulation-miR-21 and progressive downregulation-miR-143, miR-34a, miR-196b and miR-203) in the order of HPV-negative controls, HPV16-positive non-malignant samples and HPV16-positive CaCx cases. +other 30936999 hsa-mir-155 Tuberculosis, Spinal Upregulated MMP13 expression in the intervertebral disc in patients with spinal tuberculosis may be correlated with downregulated miR-155 expression. +circulation_biomarker_diagnosis_ns 30936985 hsa-mir-21 Heart Failure The plasma miR-21 expression was positively correlated with BNP in patients with PIH complicated with heart failure (r=0.685, P<0.001). +circulation_biomarker_diagnosis_ns 30936985 hsa-mir-21 Hypertension, Pregnancy-Induced The plasma miR-21 expression was positively correlated with BNP in patients with PIH complicated with heart failure (r=0.685, P<0.001). +other 30936964 hsa-mir-204 Diabetic Retinopathy 5p treatment increased the number of autophagic vacuoles, and significantly promoted LC3B-II expression and the LC3B-II/LC3B-I ratio compared with the negative control (P<0.01). +other 30936926 hsa-mir-573 idiopathic scoliosis METHODS: Quantitative reverse transcription polymerase chain reaction (qRT-PCR) analysis was applied to examine the expression of miR-573 and Bax in idiopathic scoliosis tissues and IDD tissues. +genetics_overexpression_suppress 30936926 hsa-mir-573 Intervertebral disc disease CONCLUSION: These results suggest that overexpression of miR-573 inhibited NP cell apoptosis by down-regulating Bax, which proved to be a novel effective strategy for IDD therapies. +other 30936926 hsa-mir-573 Neurodegenerative Diseases RESULTS: The results revealed that the mRNA expression level of miR-573 was down-regulated whereas Bax was up-regulated notably in degenerative NP cells. +circulation_biomarker_diagnosis_ns 30936821 hsa-mir-105 Parkinson Disease We believe that a change in the plasma miR +lncRNA target 30936265 hsa-mir-590 Osteosarcoma And there were 38 endogenous genes (including ARF1, HSP90AB1, and TUBA1B), 53 TFs (including E2F1, NFKB1, and EGR1), and 858 ncRNAs (including MALAT1, miR3p, and TUG1) were considered as key regulators of osteosarcoma through a series of function enrichment analysis and network analysis. +exosome 30936073 hsa-mir-186 Neuroblastoma The tumor-suppressive miR-186 that is downregulated in neuroblastoma and in TGFbeta-treated NK cells represses oncogenic proteins in neuroblastoma (MYCN and AURKA) and components of the TGFbeta pathway. Restoration of miR-186 levels in neuroblastoma through NK cell-derived exosomes or by nanoparticle delivery reduces tumor burden, promotes survival, and restores the cell-killing abilities of NK cells, demonstrating the therapeutic potential of tumor-suppressive miRNAs in neuroblastoma.See related article by Neviani and colleagues; Cancer Res 79(6):1151-64. +circulation_biomarker_diagnosis_up 30936013 hsa-mir-1229 Colorectal Neoplasms In this study, we found that circulating exomiR-1229 levels were significantly increased in the serum exosomes of patients with colorectal cancer (CRC) and significantly associated with tumor size, lymphatic metastasis, TNM stage and poor survival. +genetics_GWAS 30935968 hsa-mir-34 Triple Negative Breast Neoplasms Prognostic significance of miR-34 rs4938723 T>C polymorphism in triple negative breast cancer patients. OBJECTIVES The aim of this was the assessment of the prognostic role of the rs4938723 C>T polymorphism of the miR-34 in triple negative breast cancer patients. +lncRNA target 30935924 hsa-mir-298 Adrenal Cortex Neoplasms Consistently, ectopic expressed UCA1 suppressed miR-298 and up-regulated the expression of CDK6, which promoted the cell cycle progression of ACC cells. +genetics_overexpression_promote 30935821 hsa-mir-3687 Urinary Bladder Neoplasms Interestingly, overexpression of cyclin E2 reversed the inhibition of BC proliferation induced by miR-3687. +other 30935691 hsa-mir-1285 Uterine Cervical Neoplasms 3p to promote the expression of RPL14, promoting the migration, invasion and EMT of CC cells. +other 30935386 hsa-mir-363 Leukemia, Myeloid, Acute RESULTS: We found that MiR-363 is a novel prognostic factor in AML patients undergoing chemotherapy. AML patients with high miR-363 expression may be highly recommended for early allo-HSCT regimen. +genetics_GWAS 30934838 hsa-mir-27a Macular Degeneration These analyses reported that the SNPs rs11671784 (MIR27A, G/A) and rs2910164 (MIR146A, C/G) were significantly associated with AMD risk. +genetics_GWAS 30934838 hsa-mir-146a Macular Degeneration These analyses reported that the SNPs rs11671784 (MIR27A, G/A) and rs2910164 (MIR146A, C/G) were significantly associated with AMD risk. +transcription factor target 30934805 hsa-mir-21 Brain Injuries Instead, miR-200b and miR-21 dysregulation was linked to age-related cognitive impairment, and finally, stroke events and consequences were associated with an alteration in miR-200b, miR-21, and miR-124; significantly higher levels of this last expression are strongly sensitive for ischemic damage. +other 30934805 hsa-mir-34 Brain Injuries The results demonstrated that the drug abuser group showed a higher expression of miR-132 and miR-34, suggesting a specific pathway in consumption-induced neurodegeneration. +transcription factor target 30934805 hsa-mir-124 Brain Injuries Instead, miR-200b and miR-21 dysregulation was linked to age-related cognitive impairment, and finally, stroke events and consequences were associated with an alteration in miR-200b, miR-21, and miR-124; significantly higher levels of this last expression are strongly sensitive for ischemic damage. +other 30934805 hsa-mir-132 Brain Injuries The results demonstrated that the drug abuser group showed a higher expression of miR-132 and miR-34, suggesting a specific pathway in consumption-induced neurodegeneration. +transcription factor target 30934805 hsa-mir-200b Brain Injuries Instead, miR-200b and miR-21 dysregulation was linked to age-related cognitive impairment, and finally, stroke events and consequences were associated with an alteration in miR-200b, miR-21, and miR-124; significantly higher levels of this last expression are strongly sensitive for ischemic damage. +exosome 30934732 hsa-mir-423 Rabies miR5p, exosomes, and IFN signaling pathways may therefore be potential targets for improving MRC-5 cell-based rabies vaccine production. +lncRNA target 30933478 hsa-mir-34a Pancreatic Carcinoma While there is significant downregulation of tumor suppressor microRNA-34a (miR-34a), which targets many oncogenes related to proliferation, apoptosis, and invasion, high expression level of Polo-like kinase 1 (PLK1) is closely associated with short survival rates of pancreatic cancer patients. +other 30933434 hsa-let-7a Obesity This study investigated adipose IKKepsilon expression in children with and without obesity and potential involvement of the Lin28B/let-7a axis in posttranscriptional regulation of TNF-alpha-stimulated IKKepsilon in adipocytes. +other 30932942 hsa-mir-658 Uveal melanoma A comparison of primary conjunctival melanoma with their pair-matched metastases identified six significant differentially expressed miRNAs (hsa-miR-1246 and hsa-miR-302d-5p, hsa-mir-6084, hsa-miR-184, hsa-mir-658, and hsa-mir-4427). +other 30932942 hsa-mir-6084 Uveal melanoma A comparison of primary conjunctival melanoma with their pair-matched metastases identified six significant differentially expressed miRNAs (hsa-miR-1246 and hsa-miR-302d-5p, hsa-mir-6084, hsa-miR-184, hsa-mir-658, and hsa-mir-4427). +other 30932942 hsa-mir-1246 Uveal melanoma A comparison of primary conjunctival melanoma with their pair-matched metastases identified six significant differentially expressed miRNAs (hsa-miR-1246 and hsa-miR-302d-5p, hsa-mir-6084, hsa-miR-184, hsa-mir-658, and hsa-mir-4427). +other 30932942 hsa-mir-4427 Uveal melanoma A comparison of primary conjunctival melanoma with their pair-matched metastases identified six significant differentially expressed miRNAs (hsa-miR-1246 and hsa-miR-302d-5p, hsa-mir-6084, hsa-miR-184, hsa-mir-658, and hsa-mir-4427). +other 30932942 hsa-mir-184 Uveal melanoma A comparison of primary conjunctival melanoma with their pair-matched metastases identified six significant differentially expressed miRNAs (hsa-miR-1246 and hsa-miR-302d-5p, hsa-mir-6084, hsa-miR-184, hsa-mir-658, and hsa-mir-4427). +other 30932905 hsa-mir-188 Polycystic Ovary Syndrome Moreover, the hsa-miR-3188/3135b has certain diagnostic value for distinguishing PCOS. +other 30932749 hsa-mir-195 Breast Neoplasms Our findings suggest a therapeutic potential of miR-195 in both ER-positive as well as ER-negative breast cancer cells. +genetics_overexpression_promote 30932211 hsa-mir-548c Colorectal Neoplasms Moreover, the proliferation and generation of inflammatory cytokines (TNF-alpha and IL-6) were significantly inhibited in miR-548c-5p-overexpressed SW480 CRC cells stimulated by lipopolysaccharide (LPS). +lncRNA target 30932200 hsa-mir-133a Uterine Cervical Neoplasms SOX4 was able to act as a downstream target of miR-133a and silencing of SOX4 can restrain cervical cancer progression. +other 30932160 hsa-mir-21 Osteoarthritis 5p silencing as an attractive therapeutic regimen in future clinical trials involving patients with OA. +other 30931995 hsa-mir-155 Breast Neoplasms This method has been applied also for the determination of miR-155 in the human breast carcinoma MCF-7 cells and normal human embryonic kidney cell line (HEK 293). +genetics_knock down_promote 30931980 hsa-mir-21 Colonic Neoplasms These findings present a novel regulatory mechanism of 15-PGDH by miR-21, and how dysregulated expression of miR-21 may contribute to loss of 15-PGDH expression and promote CRC progression via increased accumulation of PGE(2). +lncRNA target 30931701 hsa-mir-3918 Carcinoma, Hepatocellular These results indicate that circ-BIRC6 functions as a competing endogenous RNA that regulates Bcl2 expression by sponging miR-3918, and may serve as a prognostic biomarker and therapeutic target for the treatment of HCC. +transcription factor target 30930294 hsa-mir-93 Cartilage Diseases 5p slows OA progression partially by suppressing TCF4 expression, and this phenomenon may provide novel insights into the function of miRNA in OA. +transcription factor target 30930294 hsa-mir-93 Osteoarthritis 5p slows OA progression partially by suppressing TCF4 expression, and this phenomenon may provide novel insights into the function of miRNA in OA. +transcription factor target 30930138 hsa-mir-451 Atherosclerosis Collectively, these findings indicated that miR-451 protected intimal hyperplasia and PDGF-BB-induced VSMCs injury by Ywhaz/p38 MAPK pathway, and miR-451 may be considered as a potential therapeutic target in the treatment of AS. +other 30930125 hsa-mir-9 Alzheimer Disease Analysis of microRNAs (miRNAs) revealed that miR-9 and miR-181a negatively coregulated BACE1 and TGFBIp, which was directly associated with the pathogenesis of AD and GCD2, respectively. +other 30930125 hsa-mir-181a Alzheimer Disease Analysis of microRNAs (miRNAs) revealed that miR-9 and miR-181a negatively coregulated BACE1 and TGFBIp, which was directly associated with the pathogenesis of AD and GCD2, respectively. +other 30930112 hsa-mir-143 Carcinoma, Renal Cell To understand the role of RAS-signaling networks in the pathogenesis of renal cell carcisnoma, we clarified the relationship between miR-143 and RAS. The expression of miR-143 was extremely downregulated in tumor tissues from renal cell carcinoma patients compared with that in the adjacent normal tissues and Caki-1 cells. +lncRNA target 30930097 hsa-mir-132 Ischemic Stroke Our results indicated that miR-132/MMP-9 axis might be a novel therapeutic target for BBB protection in ischemic stroke. +lncRNA target 30929576 hsa-mir-153 Thyroid cancer, medullary Targeted intravenous delivery of miR +genetics_knock down_promote 30929511 hsa-mir-1 Hypertension Ang II-induced hypertension resulted in increased expression of miR-31 in the aorta, splenic CD4(+) T cells, and kidney leukocytes. +other 30929350 hsa-mir-29b Silicotuberculosis Conclusion: Down-regulation of miRNA-29b-3p and miR-34c-3p in rat lung tissue A549 cells may be associated with the development of early silicosis and is expected to be an indicator of early silicosis diagnosis and prognosis. +other 30929350 hsa-mir-34c Silicotuberculosis Conclusion: Down-regulation of miRNA-29b-3p and miR-34c-3p in rat lung tissue A549 cells may be associated with the development of early silicosis and is expected to be an indicator of early silicosis diagnosis and prognosis. +lncRNA target 30929346 hsa-mir-379 Pulmonary Fibrosis miRNA-18a, miRNA3p, miRNA-541, miRNA-127 and miRNA-379 may play a role in the process of pulmonary fibrosis in nanosized SiO(2) and microscale SiO(2) by regulating its target genes. +lncRNA target 30929346 hsa-mir-127 Pulmonary Fibrosis miRNA-18a, miRNA3p, miRNA-541, miRNA-127 and miRNA-379 may play a role in the process of pulmonary fibrosis in nanosized SiO(2) and microscale SiO(2) by regulating its target genes. +lncRNA target 30929346 hsa-mir-18a Pulmonary Fibrosis miRNA-18a, miRNA3p, miRNA-541, miRNA-127 and miRNA-379 may play a role in the process of pulmonary fibrosis in nanosized SiO(2) and microscale SiO(2) by regulating its target genes. +lncRNA target 30929346 hsa-mir-702 Pulmonary Fibrosis miRNA-18a, miRNA3p, miRNA-541, miRNA-127 and miRNA-379 may play a role in the process of pulmonary fibrosis in nanosized SiO(2) and microscale SiO(2) by regulating its target genes. +lncRNA target 30929336 hsa-mir-27a Carcinoma, Hepatocellular Conclusion: miR-27a-3p can significantly inhibit the proliferation of hepatoma cells, promote cell apoptosis, alter the cell cycle distribution, and may become a potential target in hepatocellular carcinoma therapy. +genetics_overexpression_promote 30929159 hsa-mir-101 Carcinoma, Hepatocellular In vitro experiments indicated that miR-101 inhibits the migration and proliferation of HCC cells by targeting the HGF/c-MET axis, and in vivo studies showed that overexpressed miR-101 dramatically suppresses tumor growth. +circulation_biomarker_diagnosis_ns 30928987 hsa-mir-155 Epilepsy Finally, miR-155 levels were significantly higher in the blood of epilepsy patients than those of healthy controls. +other 30928987 hsa-mir-155 Hyperkalemia Moreover, conditioned media from KA-treated microglia impaired neuron excitability, whereas conditioned media from KA and miR-155 antagomir co-treated microglia had no such effects. +other 30928987 hsa-mir-155 Seizures Silencing miR-155 attenuated KA-induced seizure, abnormal electroencephalography, proinflammatory cytokine expression, and microglia morphology change. +other 30928188 hsa-mir-1246 Oral Submucous Fibrosis METHODS: The expression levels of miR-1246 in OSF tissues and fibrotic buccal mucosal fibroblasts (fBMFs) were examined by qRT-PCR. Our results showed that miR-1246 is positively associated with the type I collagen, which may be a downstream effector of miR-1246 and responsible for the fibrosis effect on fBMFs. +other 30928097 hsa-mir-361 Hemangioma 5p decreased in HA tissues especially in proliferating phase HAs. +genetics_knock down_suppress 30928094 hsa-mir-9 Nasopharyngeal Carcinoma Further investigations demonstrated that circRNA_000543 knockdown sensitized NPC cells by targeting miR-9/platelet-derived growth factor receptor B (PDGFRB) axis. +lncRNA target 30927925 hsa-mir-506 Colorectal Neoplasms TAMs-derived IL6 activated the JAK2/STAT3 pathway, and activated STAT3 transcriptionally inhibited the tumor suppressor miR +other 30927737 hsa-mir-155 Autoimmune enteropathy High expression levels of miR-155 are involved in the pathogenesis of inflammatory bowel disease (IBD). We observed an increase in miR-155 in peripheral regulatory T (Treg) cells from IBD patients. +transcription factor target 30927504 hsa-mir-10a Glioma In conclusion, our results indicated that miR-10a regulated cell proliferation and apoptosis by directly targeting MTMR3 and could function as a prognostic factor for progression of glioma. +other 30927387 hsa-mir-10b Breast Neoplasms Moreover, five long noncoding RNAs that could competitively bind with miR-10b, respectively, named ACTA2-AS1, RP11-384P7.7, RP11-327J17.9, RP11-124N14.3, and RP11-645C24.5, were discovered as an integration signature with great potential in the prediction of survival outcomes in patients with different stages of breast cancer. +transcription factor target 30927374 hsa-mir-21 Cardiovascular Diseases CONCLUSION AND IMPLICATIONS: These results indicate that amlodipine induces smooth muscle cell differentiation via miR-21, which is regulated by p-Akt2 and Sp1 nuclear translocation, thereby providing a novel target for cardiovascular diseases. +other 30927333 hsa-mir-106a Colorectal Neoplasms LINC00657 and miR-106a expression levels play a pivotal role in CRC. We found that upregulation of LINC00657 and downregulation of miR-106a are significantly associated with the development of CRC. +other 30927333 hsa-mir-106a Adenomatous Polyposis Coli LINC00657 and miR-106a expression levels play a pivotal role in CRC. We found that upregulation of LINC00657 and downregulation of miR-106a are significantly associated with the development of CRC. +other 30927333 hsa-mir-106a Inflammatory Bowel Diseases LINC00657 and miR-106a expression levels play a pivotal role in CRC. We found that upregulation of LINC00657 and downregulation of miR-106a are significantly associated with the development of CRC. +other 30927330 hsa-mir-106b Breast Neoplasms Altogether, for the first time, our findings reveal that ES1 controls the proliferation and death of breast cancer cells by regulating the Oct4/Sox2/miR-302/miR-106b axis. +transcription factor target 30927257 hsa-mir-22 Retinal Diseases 3p plays a suppressive role in RPE damage by targeting NLRP3, which provides new insights into the future intervention to retinopathy. +transcription factor target 30927257 hsa-mir-223 Retinal Diseases 3p plays a suppressive role in RPE damage by targeting NLRP3, which provides new insights into the future intervention to retinopathy. +lncRNA target 30927143 hsa-mir-650 Thyroid Carcinoma, Anaplastic Spearman's rank correlation test was used to assess the association between miR-650 and its target in human thyroid cancer tissues. +other 30926883 hsa-mir-221 Leukemia Here, we investigated cross-talk between the miR-221 network and P-glycoprotein (P-gp) in doxorubicin-induced drug resistance of leukemia cells. +genetics_knock down_promote 30926829 hsa-mir-449a Triple Negative Breast Neoplasms The cell viability, cell-cycle phases, and the expression of in silico target genes and proteins of sensitive/resistant triple negative breast cancer cell lines were evaluated in response to doxorubicin treatment and after gain/loss of miRNAs-449 function achieved by transient transfection. +lncRNA target 30926767 hsa-mir-205 Lung Neoplasms CONCLUSIONS To sum up, our results illustrate that upregulation of GAS5 in NSCLC suppresses its growth, migration, and invasion via the miR-205/PTEN axis. +circulation_biomarker_diagnosis_ns 30926713 hsa-mir-23b Neurosyphilis 5p, miR-203a-3p, miR-16, miR-23b-3p and miR-27b-5p in the CSF and serum of NSP and SP. +circulation_biomarker_diagnosis_ns 30926713 hsa-mir-203a Neurosyphilis 5p, miR-203a-3p, miR-16, miR-23b-3p and miR-27b-5p in the CSF and serum of NSP and SP. +circulation_biomarker_diagnosis_up 30926713 hsa-mir-590 Neurosyphilis 5p were upregulated in the CSF and serum, when compared with patients with syphilis without neurosyphilis (SP). +circulation_biomarker_diagnosis_up 30926713 hsa-mir-570 Neurosyphilis 5p were upregulated in the CSF and serum, when compared with patients with syphilis without neurosyphilis (SP). +circulation_biomarker_diagnosis_ns 30926713 hsa-mir-7 Neurosyphilis 5p, miR-203a-3p, miR-16, miR-23b-3p and miR-27b-5p in the CSF and serum of NSP and SP. +circulation_biomarker_diagnosis_ns 30926713 hsa-mir-1307 Neurosyphilis 5p, miR-203a-3p, miR-16, miR-23b-3p and miR-27b-5p in the CSF and serum of NSP and SP. +circulation_biomarker_diagnosis_ns 30926713 hsa-mir-16 Neurosyphilis 5p, miR-203a-3p, miR-16, miR-23b-3p and miR-27b-5p in the CSF and serum of NSP and SP. +circulation_biomarker_diagnosis_ns 30926713 hsa-mir-27b Neurosyphilis 5p, miR-203a-3p, miR-16, miR-23b-3p and miR-27b-5p in the CSF and serum of NSP and SP. +genetics_overexpression_promote 30926679 hsa-mir-92a Osteosarcoma Quantitative real-time PCR (qRT-PCR) results revealed that the expression of miR-92a was aberrantly overexpressed in human OS cell lines. +other 30926524 hsa-mir-145 Diabetes Complications 5p and miR-199a-5p). +other 30926524 hsa-mir-125a Diabetes Complications 5p and miR-199a-5p). +other 30926524 hsa-mir-873 Diabetes Complications 5p and miR-199a-5p). +other 30926524 hsa-mir-9 Diabetes Complications 5p and miR-199a-5p). +other 30926524 hsa-mir-501 Diabetes Complications 5p and miR-199a-5p). +other 30926524 hsa-mir-409 Diabetes Complications 5p and miR-199a-5p). +other 30926524 hsa-mir-1249 Diabetes Complications 5p and miR-199a-5p). +other 30926524 hsa-mir-148b Diabetes Complications 5p and miR-199a-5p). +other 30926524 hsa-mir-193a Diabetes Complications 5p and miR-199a-5p). +lncRNA target 30926320 hsa-mir-221 AIDS-Related Complex We concluded that miR-221 promoted lens epithelial cells apoptosis through regulating SIRT1 and E2F3, providing a novel biomarker for treatment of ARC. +other 30926320 hsa-mir-221 Cataract Results showed that high expression of miR-221 was exhibited in ARC tissues compared with that in normal samples and associated with Lens Opacities Classification System III grades. +circulation_biomarker_diagnosis_down 30926224 hsa-mir-133b Vascular Diseases The results showed that miR-133b was down-regulated in the blood and vascular plaque tissues of rabbits with atherosclerosis. +other 30925941 hsa-mir-21 Biliary Atresia In conclusions, our study provides support for the association between miRNA-21 expression and liver cirrhosis in BA patients. +other 30925941 hsa-mir-21 Liver Cirrhosis In conclusions, our study provides support for the association between miRNA-21 expression and liver cirrhosis in BA patients. +circulation_biomarker_diagnosis_ns 30925928 hsa-mir-155 Lymphoma, B-Cell Of note, EBV-positive patients showed higher serum miR155 than EBV-negative patients. MiR155-induced AKT/ERK inactivation was more obvious in CD8+T cells co-cultured with EBV-infected B-lymphoma cells. +genetics_GWAS 30925916 hsa-mir-96 Squamous Cell Carcinoma of Head and Neck RESULTS: Our data showed that overexpression of miR +circulation_biomarker_diagnosis_ns 30925324 hsa-mir-7 Osteoarthritis Decreased ciRS-7 expression and increased miR-7 expression were observed in OA blood samples. +other 30925282 hsa-mir-1260b Colorectal Neoplasms 5p, and miR-1260b) with high diagnostic efficiency for CRC; the panel distinguished CRC patients from controls with 93.8% sensitivity and 91.3% specificity. +other 30925282 hsa-mir-144 Colorectal Neoplasms 5p, and miR-1260b) with high diagnostic efficiency for CRC; the panel distinguished CRC patients from controls with 93.8% sensitivity and 91.3% specificity. +other 30925282 hsa-mir-425 Colorectal Neoplasms 5p, and miR-1260b) with high diagnostic efficiency for CRC; the panel distinguished CRC patients from controls with 93.8% sensitivity and 91.3% specificity. +circulation_biomarker_diagnosis_ns 30925002 hsa-mir-192 Chemical and Drug Induced Liver Injury The present study showed that (1) miR-122 and miR-192 are good serum biomarkers of toxic liver injury whatever its etiology, as their serum levels exhibited a significantly earlier increase and earlier return to normal baseline levels as compared to serum aminotransferase levels; (2) miR-122 is more specific than miR-192; and (3) both serum levels of miR-122 and miR-192 showed non-significant differences in relation to the type of toxic liver injury. +circulation_biomarker_diagnosis_ns 30925002 hsa-mir-122 Chemical and Drug Induced Liver Injury The present study showed that (1) miR-122 and miR-192 are good serum biomarkers of toxic liver injury whatever its etiology, as their serum levels exhibited a significantly earlier increase and earlier return to normal baseline levels as compared to serum aminotransferase levels; (2) miR-122 is more specific than miR-192; and (3) both serum levels of miR-122 and miR-192 showed non-significant differences in relation to the type of toxic liver injury. +lncRNA target 30924927 hsa-mir-135a Wounds and Injuries Therefore, we conclude that miR-135a is a potential therapeutic target for SCI and that restoration of its expression may reduce the deleterious effects of ATP-dependent excitotoxicity induced after a traumatic spinal cord injury. +lncRNA target 30924927 hsa-mir-135a Spinal Cord Injuries Therefore, we conclude that miR-135a is a potential therapeutic target for SCI and that restoration of its expression may reduce the deleterious effects of ATP-dependent excitotoxicity induced after a traumatic spinal cord injury. +lncRNA target 30924320 hsa-mir-593 Glioma CONCLUSION lncRNA ENST00000413528 is closely related to the development of glioma via the miR +genetics_GWAS 30924168 hsa-mir-374b Carcinoma, Hepatocellular Moreover, suppressor with morphogenetic effect on genitalia family member 1 (SMG1) is positively regulated by MAGI2-AS3 via absorbing miR-374b-5p in HCC cells. +genetics_knock down_suppress 30923843 hsa-mir-98 Osteosarcoma 5p attenuated SNHG16 knockdown-mediated effects on cellular processes in osteosarcoma. +genetics_overexpression_promote 30923258 hsa-mir-506 Stomach Neoplasms overexpressing gastric carcinoma cells developed significantly smaller tumor, compared to the control. +circulation_biomarker_diagnosis_up 30923228 hsa-mir-208a Cardiotoxicity Total RNAs from serum were used to hybridize with the SurePrint G3 Rat Whole Genome GE 8x60 K Microarray G4858A platform.Results: In the rat model with ketamine-induced cardiotoxicity, microRNA-208a expression was increased. +circulation_biomarker_diagnosis_ns 30922869 hsa-mir-20a Aortic Aneurysm, Abdominal miR3p and miR-548k were also increased in aneurysmal tissue and miR-20a-5p was increased in serum. +circulation_biomarker_diagnosis_ns 30922869 hsa-mir-144 Aortic Aneurysm, Abdominal miR3p and miR-548k were also increased in aneurysmal tissue and miR-20a-5p was increased in serum. +circulation_biomarker_diagnosis_ns 30922869 hsa-mir-20a Diabetes Mellitus miR3p and miR-548k were also increased in aneurysmal tissue and miR-20a-5p was increased in serum. +circulation_biomarker_diagnosis_ns 30922869 hsa-mir-548k Diabetes Mellitus miR3p and miR-548k were also increased in aneurysmal tissue and miR-20a-5p was increased in serum. +circulation_biomarker_diagnosis_ns 30922869 hsa-mir-144 Diabetes Mellitus miR3p and miR-548k were also increased in aneurysmal tissue and miR-20a-5p was increased in serum. +circulation_biomarker_diagnosis_ns 30922869 hsa-mir-548k Aortic Aneurysm, Abdominal miR3p and miR-548k were also increased in aneurysmal tissue and miR-20a-5p was increased in serum. +other 30922710 hsa-mir-203 Carcinoma, Hepatocellular We found that all studied microRNAs were down regulated among HCC patients when compared to cirrhotic patients and controls (p value: 0.005, 0.005 and 0.001 for microRNAs 191, 203 and 335 respectively). +other 30922710 hsa-mir-335 Carcinoma, Hepatocellular We found that all studied microRNAs were down regulated among HCC patients when compared to cirrhotic patients and controls (p value: 0.005, 0.005 and 0.001 for microRNAs 191, 203 and 335 respectively). +other 30922710 hsa-mir-191 Carcinoma, Hepatocellular We found that all studied microRNAs were down regulated among HCC patients when compared to cirrhotic patients and controls (p value: 0.005, 0.005 and 0.001 for microRNAs 191, 203 and 335 respectively). +circRNA target 30922709 hsa-mir-615 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 5p could be sponged by circ-LAMP1 and discoidin domain receptor tyrosine kinase 2 (DDR2) 3'-UTR is the direct target of miR +lncRNA target 30922567 hsa-mir-145 Colorectal Neoplasms In brief, the findings of the present study illustrated that circPVT1, working as an oncogene, promotes metastasis via miR-145 sponging in CRC. +lncRNA target 30922407 hsa-mir-378a Tendon Injuries CONCLUSIONS: Our investigation suggests that miR-378a could be considered as a new potential biomarker for tendon injury diagnosis or drug target for a possible therapeutic approach in future clinical practice. +other 30922384 hsa-mir-184 Neurodegenerative Diseases CONCLUSIONS: Our data highlighted that miR-184 could promote OL differentiation even in the absence of exogenous growth factors and propose a novel strategy to improve the efficacy of OL differentiation, with potential applications in cell therapy for neurodegenerative diseases. +genetics_overexpression_promote 30922374 hsa-mir-26b Melanoma Moreover, we demonstrated that TRIM44 is the target of miR-26b-5p, which is significantly downregulated in melanoma tissues and may be responsible for the overexpression of TRIM44. CONCLUSIONS TRIM44, regulated by miR-26b-5p, promotes melanoma progression by stabilizing TLR4, which then activates the AKT/mTOR pathway. +transcription factor target 30922255 hsa-mir-196b Squamous Cell Carcinoma of Head and Neck Since the expression of miR-196b in MOC-L1 xenografts is drastically decreased on cisplatin treatment, it would seem that targeting of miR-196b might facilitate tumor abrogation. +genetics_overexpression_promote 30922194 hsa-mir-4417 Triple Negative Breast Neoplasms Low expression of miR-4417 is significantly associated with worse prognosis in TNBC patients, while overexpression of miR-4417 is sufficient to inhibit migration and mammosphere formation of TNBC cells in vitro. +circulation_biomarker_prognosis_ns 30922137 hsa-mir-142 Colorectal Neoplasms CONCLUSIONS: Serum miR +other 30922080 hsa-mir-574 Lung Neoplasms miR5p as RNA decoy for CUGBP1 stimulates human lung tumor growth by mPGES-1 induction. +other 30921508 hsa-mir-297 Pituitary Diseases BACKGROUND/AIMS: Recently, microRNA-297 (miR-297) and signal transducer and activator of transcription 3 (STAT3) have been demonstrated to be involved in dysfunction of vascular endothelial cells and inflammatory conditions, such as sepsis. +other 30921508 hsa-mir-297 Inflammation BACKGROUND/AIMS: Recently, microRNA-297 (miR-297) and signal transducer and activator of transcription 3 (STAT3) have been demonstrated to be involved in dysfunction of vascular endothelial cells and inflammatory conditions, such as sepsis. +lncRNA target 30921508 hsa-mir-297 Sepsis BACKGROUND/AIMS: Recently, microRNA-297 (miR-297) and signal transducer and activator of transcription 3 (STAT3) have been demonstrated to be involved in dysfunction of vascular endothelial cells and inflammatory conditions, such as sepsis. Thus, miR-297 may be a promising therapeutic target for patients with sepsis. +other 30921188 hsa-mir-497 Squamous Cell Carcinoma of Head and Neck We have verified the altered expression of miR5p and miR-4417 in OSCC samples and related the deregulated miRNAs with the 'proteoglycans in cancer' pathway. +other 30921188 hsa-mir-4417 Squamous Cell Carcinoma of Head and Neck We have verified the altered expression of miR5p and miR-4417 in OSCC samples and related the deregulated miRNAs with the 'proteoglycans in cancer' pathway. +circulation_biomarker_prognosis_up 30921182 hsa-mir-122 Carcinoma, Hepatocellular However, the expression level of miR-122 in blood did not have the ability in predicting OS (HR = 0.75, 95% CI 0.44-1.28, P = .29) and PFS (HR = 0.84, 95% CI 0.58-1.20, P = .33) of HCC. +other 30920730 hsa-mir-21 Carcinoma, Ovarian Epithelial Besides the complementarity of the second strand to the anchor sequence, it includes the complementary sequence to the microRNAs (miRNA)-21 or miRNA-221 that is specific miRNA biomarker for MCF-7 breast cancer cells or OVCAR-3 ovarian cancer cells. Preliminary cell experiments reveal that the respective NMOFs are unlocked by the miRNA-21 or miRNA-221, resulting in selective cytotoxicity toward MCF-7 breast cancer cells or OVCAR-3 ovarian cancer cells. +other 30920730 hsa-mir-21 Breast Neoplasms Besides the complementarity of the second strand to the anchor sequence, it includes the complementary sequence to the microRNAs (miRNA)-21 or miRNA-221 that is specific miRNA biomarker for MCF-7 breast cancer cells or OVCAR-3 ovarian cancer cells. Preliminary cell experiments reveal that the respective NMOFs are unlocked by the miRNA-21 or miRNA-221, resulting in selective cytotoxicity toward MCF-7 breast cancer cells or OVCAR-3 ovarian cancer cells. +other 30920730 hsa-mir-221 Carcinoma, Ovarian Epithelial Besides the complementarity of the second strand to the anchor sequence, it includes the complementary sequence to the microRNAs (miRNA)-21 or miRNA-221 that is specific miRNA biomarker for MCF-7 breast cancer cells or OVCAR-3 ovarian cancer cells. Preliminary cell experiments reveal that the respective NMOFs are unlocked by the miRNA-21 or miRNA-221, resulting in selective cytotoxicity toward MCF-7 breast cancer cells or OVCAR-3 ovarian cancer cells. +other 30920730 hsa-mir-221 Breast Neoplasms Besides the complementarity of the second strand to the anchor sequence, it includes the complementary sequence to the microRNAs (miRNA)-21 or miRNA-221 that is specific miRNA biomarker for MCF-7 breast cancer cells or OVCAR-3 ovarian cancer cells. Preliminary cell experiments reveal that the respective NMOFs are unlocked by the miRNA-21 or miRNA-221, resulting in selective cytotoxicity toward MCF-7 breast cancer cells or OVCAR-3 ovarian cancer cells. +circulation_biomarker_prognosis_up 30920086 hsa-mir-1246 Carcinoma, Hepatocellular CONCLUSION Circulating miR-1246 in serum has strong potential as a novel ETR and prognostic biomarker for HCC. +lncRNA target 30920079 hsa-mir-206 Breast Neoplasms Expression analysis of selected miR-206 targets from the transforming growth factor- signaling pathway in breast cancer. +genetics_overexpression_promote 30920025 hsa-mir-188 Carcinoma, Hepatocellular 5p overexpression inhibited the HCC cell proliferation. +other 30918974 hsa-mir-203a Squamous Cell Carcinoma of Head and Neck Our data suggest that COL17 expression in OSCC cell lines is regulated by p53 and miR203a-3p. +circulation_biomarker_prognosis_up 30918471 hsa-mir-155 Critical Illness RESULTS: By using qPCR, we demonstrate that miR-155 serum levels are elevated in patients with critical illness when compared to controls. +other 30918429 hsa-mir-29 Liver Cirrhosis The ADC correlated with miR-200b (r = - 0.61, P = 0.001), miR-21 (r = - 0.62, P = 0.001), and miR-29 (r = 0.52, P = 0.001). +other 30918429 hsa-mir-21 Liver Cirrhosis The ADC correlated with miR-200b (r = - 0.61, P = 0.001), miR-21 (r = - 0.62, P = 0.001), and miR-29 (r = 0.52, P = 0.001). +other 30918429 hsa-mir-21 Hepatitis C, Chronic The ADC correlated with miR-200b (r = - 0.61, P = 0.001), miR-21 (r = - 0.62, P = 0.001), and miR-29 (r = 0.52, P = 0.001). +other 30918429 hsa-mir-29 Hepatitis C, Chronic The ADC correlated with miR-200b (r = - 0.61, P = 0.001), miR-21 (r = - 0.62, P = 0.001), and miR-29 (r = 0.52, P = 0.001). +genetics_overexpression_promote 30918328 hsa-mir-200b Lung Neoplasms Here, using integrated bioinformatics approaches, we identified the RNA-binding protein (RBP) quaking (QKI) as a leading miR-200b endothelial target with previously unappreciated roles in the tumor microenvironment in lung cancer. In lung cancer samples, both miR-200b suppression and QKI overexpression corresponded with tumor ECs relative to normal ECs, and QKI silencing phenocopied miR-200b-mediated inhibition of sprouting. +lncRNA target 30918109 hsa-mir-431 Adrenocortical Carcinoma RESULTS: microRNA-431 (miR-431) was underexpressed in patients with ACC with progressive disease undergoing adjuvant therapy. We found that a reversal of epithelial-mesenchymal transition underlies the action of miR-431 with doxorubicin treatment, with Zinc Finger E-Box Binding Homeobox 1 implicated as the molecular target of miR-431 in ACC. +genetics_overexpression_promote 30917930 hsa-mir-574 Stomach Neoplasms 3p overexpression reduced the migratory and invasive properties of the SGC7901/DDP cells and inhibited cisplatin (DDP) resistance in vitro and in vivo. +lncRNA target 30917918 hsa-let-7 Breast Neoplasms HMGA2 axis to induce CSC through epithelial-mesenchymal transition (EMT). +other 30917906 hsa-mir-183 Retinoblastoma We used bioinformatic tools to construct a complete regulatory axis including TET1-has_circ_0093996-miRPDCD4 that regulates RB pathogenesis. +genetics_overexpression_promote 30917455 hsa-mir-96 Stomach Neoplasms The results of CCK-8 assay and Transwell assay showed that overexpression of miRNA +circulation_biomarker_prognosis_ns 30917420 hsa-mir-29b Hypertrophy, Left Ventricular The circulation microRNA-29b might be a useful biomarker with prognostic value in left ventricular hypertrophy in hypertension patients. +circulation_biomarker_diagnosis_up 30916832 hsa-mir-150 Urinary Bladder Neoplasms Altered expression of plasma lncRNA CASC11 and miRNA-150 separated patients with bladder cancer from healthy controls. +lncRNA target 30916815 hsa-mir-34a Breast Neoplasms Our results are indicating that miR-16 and miR-34a can collaborate in breast tumor suppression. +lncRNA target 30916815 hsa-mir-16 Breast Neoplasms Our results are indicating that miR-16 and miR-34a can collaborate in breast tumor suppression. +transcription factor target 30916745 hsa-mir-664-2 Pars Planitis Our results suggested that attenuated miR2 might participate in PP pathogenesis through enhancing the NMDAR1 signaling. +genetics_knock down_suppress 30915884 hsa-mir-29b Pancreatic Carcinoma MSC-AS1 knockdown inhibited CDK14 protein levels and PDAC proliferation and enhanced gemcitabine-induced cell death and apoptosis while miR-29b-3p inhibition exerted an opposing effect; the effect of MSC-AS1 knockdown was partially attenuated by miR-29b-3p inhibition. +genetics_knock down_suppress 30915776 hsa-mir-34b Pulmonary Fibrosis CONCLUSIONS: MiR-34b-5p knockdown appears to enhance the resistance to bleomycin by regulating its target gene TIMP3 during the pathogenesis of lung fibrosis. +transcription factor target 30915770 hsa-mir-155 Atherosclerosis 5p inhibits the proliferation and migration of VSMCs and HUVECs in atherosclerosis by targeting AKT1. +genetics_knock down_promote 30915769 hsa-mir-21 Atherosclerosis RESULTS: Compared with that in miR-NC group, the level of AS in miR-21 knockdown rats were decreased significantly (p < 0.05). +other 30915768 hsa-mir-181d Myocarditis CONCLUSIONS: miR-30a and -181d contribute to the over-activated inflammatory response to viral infection of the heart during coxsackievirus infection. +other 30915768 hsa-mir-181d Viral Myocarditis CONCLUSIONS: miR-30a and -181d contribute to the over-activated inflammatory response to viral infection of the heart during coxsackievirus infection. +lncRNA target 30915760 hsa-mir-146a Inflammatory Bowel Diseases OBJECTIVE: To study the effect of micro ribonucleic acid (miR)-146a on the development of ulcerative colitis (UC) and to explore its regulatory effect on the Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88) and nuclear factor-kappa B (NF-kappaB) signaling pathways. CONCLUSIONS: We found that miR-146a inhibitor alleviates UC by reducing the release of inflammatory factors through suppressing the TLR4/MyD88/NF-kappaB signaling pathway. +genetics_GWAS 30915756 hsa-mir-140 Fractures, Bone 5p can significantly promote osteogenesis of ACSs by directly regulating its' target genes, TLR4 and BMP2, and that combined adipose scaffold with genetically modified ASCs can significantly enhance fracture-healing and bone formation in the atrophic nonunion rat model. +genetics_GWAS 30915756 hsa-mir-140 Atrophy 5p can significantly promote osteogenesis of ACSs by directly regulating its' target genes, TLR4 and BMP2, and that combined adipose scaffold with genetically modified ASCs can significantly enhance fracture-healing and bone formation in the atrophic nonunion rat model. +lncRNA target 30915755 hsa-mir-1275 Leukemia, Myelogenous, Chronic, BCR-ABL Positive CONCLUSIONS: HAND2-AS1 was downregulated and miR-1275 was upregulated in CML, and HAND2-AS1 inhibited proliferation and promoted apoptosis of CML cells by sponging with microRNA-1275, which might be a novel therapeutic target for CML. +lncRNA target 30915753 hsa-mir-296 Thyroid Cancer, Papillary Importantly, PLK1 reversed the inhibitory effects of miR +lncRNA target 30915751 hsa-mir-483 Breast Neoplasms CONCLUSIONS: These results suggested that miR-483 could suppress BC cell proliferation and promote BC cell apoptosis via targeting SOX3, which might be a potential therapeutic target in BC. +lncRNA target 30915749 hsa-mir-99a Nasopharyngeal Carcinoma CONCLUSIONS: We provided evidence that miR-99a inhibits NPC cell proliferative ability by inhibiting mTOR. +lncRNA target 30915748 hsa-mir-5702 Carcinoma, Non-Small-Cell Lung OBJECTIVE Significant down-regulation of miR-5702 and its tumor-suppressive roles in non-small-cell lung cancer (NSCLC) have been reported previously. +transcription factor target 30915747 hsa-mir-34b Carcinoma, Non-Small-Cell Lung Thus, our findings provide new insight into the molecular mechanisms of lung cancer metastasis and miR-34b may serve as a potential target in the treatment of human lung cancer. +genetics_overexpression_promote 30915746 hsa-mir-503 Carcinoma, Hepatocellular WEE1 overexpression impaired the inhibitory effect of miR +lncRNA target 30915745 hsa-mir-888 Carcinoma, Hepatocellular The newly identified miR-888/SMAD4 axis provides novel insight into the progression of HCC and offers a promising target for HCC therapy. +transcription factor target 30915741 hsa-mir-338 Urinary Bladder Neoplasms 3p inhibited the proliferation, metastasis and EMT in BC by suppressing ETS, showing that miR +lncRNA target 30915740 hsa-mir-132 Pancreatic Carcinoma Pancreatic cancer cell line (MiaPaCe-2a) was transfected with miR-132 mimics and inhibitor. +lncRNA target 30915738 hsa-mir-101 Uterine Cervical Neoplasms 5p suppressed the progression of cervical cancer by targeting CXCL6 and might function as a potential therapeutic target for cervical cancer. +lncRNA target 30915736 hsa-mir-15a Ovarian Neoplasms Furthermore, a xenograft model indicated that miR-15a-3p inhibited tumour growth and the metastatic potential of ovarian cancer cell in vivo. +genetics_overexpression_promote 30915734 hsa-mir-630 Osteosarcoma Functional investigation showed that miR-630 overexpression inhibited cell growth, colony formation, migration, invasion and EMT pathway, and promoted apoptosis in OS. +lncRNA target 30915733 hsa-mir-20a Arthritis, Rheumatoid OBJECTIVE: To study the expression of micro ribonucleic acid (miR)-320a in synovial tissues of patients with rheumatoid arthritis (RA) and explore the influences of miR-320a on the proliferation and apoptosis of fibroblast-like synoviocytes (FLSs) in RA and its mechanism. +lncRNA target 30915731 hsa-mir-92b Spinal Cord Injuries The locomotor evaluation of miR-92b-5p inhibitor group was dramatically higher than that of the SCI group. +genetics_overexpression_promote 30915729 hsa-mir-409 Polycystic Ovary Syndrome Overexpression of microRNA-409 could improve hormone levels and pregnancy rate in PCOS rats, as well as affect clinical phenotypes of their offspring. +transcription factor target 30915607 hsa-mir-124 Glioma Furthermore, sevoflurane inhibits glioma cells proliferation, migration and invasion through miR +circulation_biomarker_diagnosis_up 30915368 hsa-mir-150 Dermatomyositis 5p were significantly downregulated in the peripheral blood mononuclear cells (PBMCs) from DM patients. +genetics_overexpression_suppress 30915129 hsa-mir-214 Colonic Neoplasms Overexpression of Hsp27 could block miR-214 with an effect on the sensitivity of colon cancer cells to 5-FU. +circulation_biomarker_diagnosis_ns 30914946 hsa-mir-361 Alzheimer Disease Six different microRNAs (miR-181a-5p, miR3p, miR-23a-3p, miR-15b-3p, 130a-3p and miR-27b-3p) that bind the SNAP-25 3'UTR region were measured by qPCR in serum of AD patients (n = 22), mild cognitive impairment (MCI) subjects (n = 22) and age- and sex-matched controls (n = 22); analysis of results was done stratified for the rs363050 SNAP-25 genotype. +circulation_biomarker_diagnosis_ns 30914946 hsa-mir-27b Alzheimer Disease Six different microRNAs (miR-181a-5p, miR3p, miR-23a-3p, miR-15b-3p, 130a-3p and miR-27b-3p) that bind the SNAP-25 3'UTR region were measured by qPCR in serum of AD patients (n = 22), mild cognitive impairment (MCI) subjects (n = 22) and age- and sex-matched controls (n = 22); analysis of results was done stratified for the rs363050 SNAP-25 genotype. +circulation_biomarker_diagnosis_ns 30914946 hsa-mir-23a Alzheimer Disease Six different microRNAs (miR-181a-5p, miR3p, miR-23a-3p, miR-15b-3p, 130a-3p and miR-27b-3p) that bind the SNAP-25 3'UTR region were measured by qPCR in serum of AD patients (n = 22), mild cognitive impairment (MCI) subjects (n = 22) and age- and sex-matched controls (n = 22); analysis of results was done stratified for the rs363050 SNAP-25 genotype. +circulation_biomarker_diagnosis_ns 30914946 hsa-mir-181a Alzheimer Disease Results showed that miR-27b-3p, miR-23a-3p and miR181a-5p serum concentration was significantly reduced in rs363050 SNAP-25 GG homozygous AD patients. +circulation_biomarker_diagnosis_ns 30914946 hsa-mir-15b Alzheimer Disease Six different microRNAs (miR-181a-5p, miR3p, miR-23a-3p, miR-15b-3p, 130a-3p and miR-27b-3p) that bind the SNAP-25 3'UTR region were measured by qPCR in serum of AD patients (n = 22), mild cognitive impairment (MCI) subjects (n = 22) and age- and sex-matched controls (n = 22); analysis of results was done stratified for the rs363050 SNAP-25 genotype. +other 30914462 hsa-mir-579 Vascular Diseases Intervention of cPWWP2A or miR-579 expression may offer opportunities for treating diabetic microvascular complications. +other 30914462 hsa-mir-579 Diabetes Mellitus Intervention of cPWWP2A or miR-579 expression may offer opportunities for treating diabetic microvascular complications. +circulation_biomarker_diagnosis_up 30914454 hsa-mir-383 Alzheimer Disease 5p in plasma of patients with AD were significantly lower than those in the control group. +circulation_biomarker_diagnosis_up 30914454 hsa-mir-381 Alzheimer Disease 5p in plasma of patients with AD were significantly lower than those in the control group. +circulation_biomarker_diagnosis_up 30914454 hsa-mir-153 Alzheimer Disease 5p in plasma of patients with AD were significantly lower than those in the control group. +circulation_biomarker_diagnosis_up 30914454 hsa-mir-144 Alzheimer Disease 5p in plasma of patients with AD were significantly lower than those in the control group. +circulation_biomarker_diagnosis_up 30914454 hsa-mir-101 Alzheimer Disease 5p in plasma of patients with AD were significantly lower than those in the control group. +transcription factor target 30914375 hsa-mir-155 Inflammation In conclusion, the present study reveals a novel signaling pathway, the miR-142a-3p/miR5p/Peli1 axis in METH-mediated neuroinflammation, and this pathway could be a potential therapeutic target for METH-mediated neurotoxicity. +transcription factor target 30914375 hsa-mir-142a Inflammation In conclusion, the present study reveals a novel signaling pathway, the miR-142a-3p/miR5p/Peli1 axis in METH-mediated neuroinflammation, and this pathway could be a potential therapeutic target for METH-mediated neurotoxicity. +genetics_overexpression_suppress 30914234 hsa-mir-660 Stomach Neoplasms Furthermore, E2F3 overexpression abrogated the anti-proliferation effect of miR-660 in GC cell lines. +genetics_overexpression_promote 30914197 hsa-mir-760 Glioma We proved that miR-760 suppresses glioma progression and FOXA1 overexpression reversed it. In conclusion, our findings revealed that LOC730100 promoted glioma progression through regulating miR-760/FOXA1 axis. +transcription factor target 30913872 hsa-mir-1246 Lung Neoplasms Based on the A549 cells transfected with miR-1246 mimics or miR-1246 inhibitor,we further measured the roles of miR-1246 involving in the epithelial-mesenchymal transition (EMT), migration and invasion capacities of lung cancer cells in vitro. +other 30913872 hsa-mir-1246 Adenocarcinoma of Lung The cell assays indicated that miR-1246 significantly increased the migration and invasion capabilities of A549 lung cancer cells. +circulation_biomarker_diagnosis_ns 30913118 hsa-mir-23a Colorectal Neoplasms RESULTS: There were high expressions of exosomal miR-23a and miR-301a in serum samples of CRC patients compared to normal controls in training and validation phases; these differences were not significantly correlated with clinicopathologic features. +genetics_overexpression_promote 30912183 hsa-mir-448 Carcinoma, Non-Small-Cell Lung Briefly, overexpression of miR-448 inhibited cell proliferation, metastasis, and EMT by suppressing IRS2 expression in NSCLC. +other 30912130 hsa-mir-5095 Carcinoma, Hepatocellular In conclusion, our findings elucidate that the LOC105369748/miR-5095/MBD2 signaling axis regulates the HCC progression and may be a novel therapeutic avenue. +lncRNA target 30912043 hsa-mir-122 Acquired Immunodeficiency Syndrome To showcase its potential, we employ this method for screening of gRNAs targeting the murine miR-122 locus in Hepa1-6 cells (using AAV serotype 6, AAV6) or the 5'LTR of the human immunodeficiency virus (HIV) in HeLaP4-NLtr cells (using a synthetic AAV9 variant). +circulation_biomarker_diagnosis_ns 30911942 hsa-let-7i ankylosing spondylitis 1 Plasma let-7i levels may serve as a biomarker for the diagnosis of AS in Mexican individuals. +circulation_biomarker_diagnosis_ns 30911942 hsa-mir-221 ankylosing spondylitis 1 Plasma let-7i, miR-16, and miR-221 levels as candidate biomarkers for the assessment of ankylosing spondylitis in Mexican patients nave to anti-TNF therapy. +circulation_biomarker_diagnosis_ns 30911942 hsa-mir-16 ankylosing spondylitis 1 Notably, plasma miR-16 levels were inversely correlated with the ASDAS-CRP score (rho -64, -0.87 to -0.18; P=0.011), the BASFI score (rho -0.78, -0.93 to -0.43; P=0.001), and serum MMP-1 levels (rho -0.59, -0.85 to -0.09; P=0.022). +lncRNA target 30911940 hsa-mir-25 Spinal Cord Injuries 3p attenuated secondary injury after SCI through inhibition of EGFR/MAPK signaling pathway, the microglial activation, and the release of inflammatory cytokines, suggesting that miR +genetics_GWAS 30911286 hsa-mir-208a Breast Neoplasms METHODS: A patient cohort and BrCa cells were recruited to demonstrate the role of functional SNP in microRNA-208a-5p binding site of DAAM1 3'-UTR and underlying mechanism in BrCa metastasis. +genetics_GWAS 30911036 hsa-mir-129 Child Development Disorders, Pervasive In addition, we showed that Fragile X Mental Retardation gene 1 (Fmr1), which is mutated in the autism spectrum disorder fragile X syndrome, is an important regulatory target for miR5p. +genetics_GWAS 30911036 hsa-mir-129 Fragile X Syndrome In addition, we showed that Fragile X Mental Retardation gene 1 (Fmr1), which is mutated in the autism spectrum disorder fragile X syndrome, is an important regulatory target for miR +lncRNA target 30910842 hsa-mir-216a Breast Neoplasms Therefore, DANCR might act as a tumor promoter by targetting miRNA-216a-5p, which might provide a potential therapy target for breast cancer treatment. +genetics_overexpression_promote 30910841 hsa-mir-188 Carcinoma, Hepatocellular 5p overexpression led to inhibited proliferation of cells of HCC cell lines. +lncRNA target 30910589 hsa-mir-365a Pancreatic Carcinoma Our observations suggest that sulforaphane-induced miR-365a-3p expression inhibits NF-kappaB activity by downregulating c-Rel, which prevents the progression of PDA. +other 30910587 hsa-mir-200a Carcinoma, Hepatocellular A significant inverse correlation between microRNA-200a/-183 and UGT1A9 mRNA level was observed in a panel of HCC specimens. MicroRNA-200a/-183 downregulated UGT1A9 expression in a dose-dependent manner and significantly reduced sorafenib beta-D-glucuronide formation in HCC cells. +other 30910587 hsa-mir-183 Carcinoma, Hepatocellular A significant inverse correlation between microRNA-200a/-183 and UGT1A9 mRNA level was observed in a panel of HCC specimens. MicroRNA-200a/-183 downregulated UGT1A9 expression in a dose-dependent manner and significantly reduced sorafenib beta-D-glucuronide formation in HCC cells. +genetics_GWAS 30910254 hsa-mir-204 Carcinoma, Endometrioid 5p is down-regulated in endometrial carcinoma and affects the prognostic significance of endometrial carcinoma, which might play an important role in the tumorigenesis of endometrial carcinoma. +other 30909216 hsa-mir-138-2 Alzheimer Disease We identified 86 CNVs in miR genes of which 31 were exclusive to EOAD cases, including a duplication of the MIR138-2 locus. This study suggests that increased gene dosage of MIR138-2 could contribute to risk for EOAD by regulating different biological pathways implicated in amyloid and tau metabolism. +circRNA target 30909190 hsa-mir-205 Urinary Bladder Neoplasms The circ0001429 could target at miR +circulation_biomarker_prognosis_ns 30909187 hsa-mir-25 Stomach Neoplasms CONCLUSIONS: Serum levels of miR-25 could improve gastric cancer screening, and as the better diagnostic and prognostic marker of gastric cancer. +genetics_knock down_promote 30909144 hsa-mir-376a Breast Neoplasms Furthermore, ectopic expression of NRP-1 or miR-376a knockdown rescued the inhibitory effects of NRP-1 knockdown on the stemness of breast cancer cells. +genetics_knock down_promote 30909141 hsa-mir-1301 Osteosarcoma Notably, suppression of miR-1301 rescued SNHG16 knockdown attenuated OS cell proliferation, migration and invasion. +genetics_overexpression_promote 30909133 hsa-mir-107 Osteoarthritis Overexpression of miR-107 inhibited apoptosis and promoted autophagy in OA chondrocytes. +genetics_knock down_promote 30909065 hsa-mir-7 Colorectal Neoplasms CONCLUSIONS: Overexpressed miR-7 suppresses angiogenesis of CRC cells through ERK signaling by downregulating EGFR. +lncRNA target 30908814 hsa-mir-940 Gingival Overgrowth CONCLUSIONS: miR5p inhibited cell proliferation, enhanced the osteo/dentinogenic differentiation of GMSCs, and might play a role in DIGO as a potent agent in the treatment of nifedipine-induced gingival overgrowth. +lncRNA target 30908814 hsa-mir-940 Gerodermia osteodysplastica 5p inhibited cell proliferation, enhanced the osteo/dentinogenic differentiation of GMSCs, and might play a role in DIGO as a potent agent in the treatment of nifedipine-induced gingival overgrowth. +lncRNA target 30908730 hsa-mir-144 Uterine Cervical Neoplasms In conclusion, the lncRNA ATB/miR-144/ITGA6 axis might be a promising therapeutic target for cervical cancer. +lncRNA target 30908634 hsa-mir-2392 Carcinoma, Hepatocellular Collectively, CACNA1G-AS1 promotes HCC progression through regulating the miR-2392/C1orf61 pathway. +lncRNA target 30907988 hsa-mir-106b Stomach Neoplasms RESULTS: To explore the function of miR-106b in EGC, we investigated the downstream signaling of miR-106b and found that ALEX1 was a direct target of miR-106 in gastric cancer cells. +lncRNA target 30907988 hsa-mir-106 Stomach Neoplasms RESULTS: To explore the function of miR-106b in EGC, we investigated the downstream signaling of miR-106b and found that ALEX1 was a direct target of miR-106 in gastric cancer cells. +transcription factor target 30907506 hsa-mir-92a Glycogen Storage Disease, Type IXD Transfection of miR-92a mimic partially restored the effect of MLCK's deficiency and antagonized the effect of Y27632 (an inhibitor of ROCK) on the down-regulation of VSMCs activities. +transcription factor target 30907227 hsa-mir-506 Squamous Cell Carcinoma of Head and Neck Restoring the expression level of miR-506 in cultured LSCC cells significantly inhibited proliferation, migration and invasion of the cells. +lncRNA target 30907089 hsa-mir-132 Diabetes Mellitus Testosterone plus voluntary exercise improved angiogenesis possibly through enhancement of miR-132 levels in heart of castrated diabetic rats. +genetics_overexpression_promote 30906802 hsa-mir-532 nonpapillary renal cell carcinoma Rescue assays of AQP9 overexpression showed that the miR-532/AQP9 axis was closely involved in RCC oncogenesis. +circRNA target 30906652 hsa-mir-183 Lung Neoplasms Human lung tumor cell lines confirmed the reverse relationship in expression of MICA/B and miR-183. Thus, high miR-183 triggered by TGFbeta expressed in lung tumor cells can target MICA/B expression to circumvent detection by NKG2D on immune cells. +lncRNA target 30906631 hsa-mir-1205 Carcinoma, Non-Small-Cell Lung Together, our study firstly confirmed a potential synergy between KRAS and MDM4/E2F1 which are p53/RB inactivators in non-small cell lung cancer, and identified miR-1205 as a potent destructor of this synergy, making miR-1205 function as a tumor suppressor in vitro and in vivo. +transcription factor target 30906627 hsa-mir-940 Glioma Here, we found that miR-940 was one of the primary downregulated miRNAs in clinical samples and glioma cell lines through bioinformatics analysis and qRT-PCR. Together, the results of our study suggest that miR-940 may be a new therapeutic target for the treatment of glioma through targeting of MTHFD2. +circulation_biomarker_diagnosis_ns 30906544 hsa-mir-122 Hepatitis C, Chronic In summary, treatment of HCV with Daclatasvir/Asunaprevir resulted in elevated LDL, and relative miR122 and PCSK9-A levels in serum appeared to have some association with LDL increase. +lncRNA target 30906475 hsa-mir-128 Glioma 3p suppresses glioma through the NPTX1/IRS-1/PI3K/AKT signaling pathway. +lncRNA target 30906474 hsa-mir-124 Reperfusion Injury, Cerebral Ischemia In summary, during the early stage of cerebral ischemia and reperfusion, the dynamic expression of microRNA-124 exhibited protective effects through the inhibition of apoptosis via anti-apoptotic proteins Bcl-2 and STAT3. +transcription factor target 30906463 hsa-mir-221 Ischemic Stroke Consequently, the target genes of miR-124, miR-221 and miR-223, correlated with ischemic stroke, were predicted using the new target prediction algorithm. +transcription factor target 30906463 hsa-mir-124 Ischemic Stroke Consequently, the target genes of miR-124, miR-221 and miR-223, correlated with ischemic stroke, were predicted using the new target prediction algorithm. +transcription factor target 30906463 hsa-mir-223 Ischemic Stroke Consequently, the target genes of miR-124, miR-221 and miR-223, correlated with ischemic stroke, were predicted using the new target prediction algorithm. +other 30906433 hsa-mir-183 Carcinoma, Renal Cell The product of the miR-183/182/96 gene cluster, namely miR-183, miR-96 and miR-182, was revealed to be associated with multiple clinicopathological features of KIRC and to have a significant predictive and prognostic value. Taken together, the present study suggested that miR-183, miR-96 and miR-182 may function as potential carcinogenic factors in KIRC and may be utilized as prognostic predictors. +other 30906433 hsa-mir-182 Carcinoma, Renal Cell The product of the miR-183/182/96 gene cluster, namely miR-183, miR-96 and miR-182, was revealed to be associated with multiple clinicopathological features of KIRC and to have a significant predictive and prognostic value. Taken together, the present study suggested that miR-183, miR-96 and miR-182 may function as potential carcinogenic factors in KIRC and may be utilized as prognostic predictors. +other 30906433 hsa-mir-96 Carcinoma, Renal Cell The product of the miR-183/182/96 gene cluster, namely miR-183, miR-96 and miR-182, was revealed to be associated with multiple clinicopathological features of KIRC and to have a significant predictive and prognostic value. Taken together, the present study suggested that miR-183, miR-96 and miR-182 may function as potential carcinogenic factors in KIRC and may be utilized as prognostic predictors. +lncRNA target 30906331 hsa-mir-29c Biliary Atresia MiR-29c might be a candidate for alleviating BA-related fibrosis by targeting DNMT3A and DNMT3B. +lncRNA target 30906331 hsa-mir-29c Diabetic Nephropathies MiR-29c might be a candidate for alleviating BA-related fibrosis by targeting DNMT3A and DNMT3B. +other 30905898 hsa-mir-150 Renal Insufficiency, Chronic Logistic regression analyses showed significantly lower odds ratios for CKD (eGFR <60 mL/min/1.73 m(2)) in the highest tertile of all three miRNAs (miR-17, miR-21, and miR-150) compared with the lowest tertile (P = 0.003, 0.01, and 0.02, respectively). +other 30905898 hsa-mir-17 Renal Insufficiency, Chronic Logistic regression analyses showed significantly lower odds ratios for CKD (eGFR <60 mL/min/1.73 m(2)) in the highest tertile of all three miRNAs (miR-17, miR-21, and miR-150) compared with the lowest tertile (P = 0.003, 0.01, and 0.02, respectively). +other 30905898 hsa-mir-21 Renal Insufficiency, Chronic Logistic regression analyses showed significantly lower odds ratios for CKD (eGFR <60 mL/min/1.73 m(2)) in the highest tertile of all three miRNAs (miR-17, miR-21, and miR-150) compared with the lowest tertile (P = 0.003, 0.01, and 0.02, respectively). +genetics_knock down_promote 30905893 hsa-mir-619 Retinoblastoma Moreover, RIN1 knockdown completely blocked miR +other 30904920 hsa-mir-222 Colonic Neoplasms MATERIAL AND METHODS In this study, we compared the expression of miR3p in DOX-resistant colon cancer cells (LoVo/ADR) with the corresponding DOX-sensitive parental cells (LoVo/S) using quantitative real-time PCR. +lncRNA target 30904818 hsa-mir-206 Thyroid Cancer, Papillary In addition, up-regulation of miR-206 inhibited the proliferation, induced apoptosis, suppressed the expressions of multidrug resistance-related proteins, including p-gp, MRP, BCRP and LRP, in euthyrox-resistant PTC cells. +lncRNA target 30904666 hsa-mir-369 Infant Nutrition Disorders This reversal is paralleled by the expression of three miRNAs that become dysregulated by perinatal malnutrition (miR +lncRNA target 30904666 hsa-mir-187 Infant Nutrition Disorders This reversal is paralleled by the expression of three miRNAs that become dysregulated by perinatal malnutrition (miR +lncRNA target 30904666 hsa-mir-187 Anxiety Disorders This reversal is paralleled by the expression of three miRNAs that become dysregulated by perinatal malnutrition (miR +lncRNA target 30904666 hsa-mir-369 Anxiety Disorders This reversal is paralleled by the expression of three miRNAs that become dysregulated by perinatal malnutrition (miR +genetics_GWAS 30904593 hsa-mir-146a Ovarian Neoplasms, High-Grade Serous Identification of miR-146a and miR-196a-2 single nucleotide polymorphisms at patients with high-grade serous ovarian cancer. We aimed to identify miR-146a rs2910164 and miR-196a-2 rs11614913 polymorphisms in ovarian cancer patients and controls. +genetics_GWAS 30904593 hsa-mir-196a-2 Ovarian Neoplasms, High-Grade Serous Identification of miR-146a and miR-196a-2 single nucleotide polymorphisms at patients with high-grade serous ovarian cancer. We aimed to identify miR-146a rs2910164 and miR-196a-2 rs11614913 polymorphisms in ovarian cancer patients and controls. +genetics_overexpression_promote 30904552 hsa-mir-101 Idiopathic Condylar Resorption 3p was the most overexpressed in ICR. +lncRNA target 30904360 hsa-mir-99a Squamous Cell Carcinoma of Head and Neck FunRich and DAVID were used for the pathway signaling analyses for the potential targets of miR-99a-3p in HNSCC. +lncRNA target 30904162 hsa-mir-126 Aortic Aneurysm, Thoracic 3p through ERK1/2 inactivation. +other 30904000 hsa-mir-155 psoriasis 1 CONCLUSIONS This study demonstrates down-regulation of miR155 after treatment with MTX and NB-UVB in psoriatic skin lesion. +lncRNA target 30903795 hsa-mir-744 Status Asthmaticus CONCLUSIONS The presence of miR-744 repressed bronchial epithelial cells proliferation through mediating the Smad3 pathway by modulating TGF-ss1, providing a promising therapeutic approach for epithelial function in severe asthma. +genetics_overexpression_promote 30903594 hsa-mir-1179 Stomach Neoplasms Overexpression of miR-1179 significantly inhibited the proliferation and invasion of gastric cancer cells. +circRNA target 30903189 hsa-mir-93 Inflammation Circular RNA 0039411 Is Involved in Neodymium Oxide-induced Inflammation and Antiproliferation in a Human Bronchial Epithelial Cell Line via Sponging miR +lncRNA target 30902962 hsa-mir-1273e Stomach Neoplasms CONCLUSIONS LINC01138 activated the MAPK signaling pathway by inhibiting miR-1273e to promote GC cell proliferation, invasion, and migration, and inhibit GC cell apoptosis, suggesting that the LINC01138/miR-1273e/MAPK axis is a promising therapeutic target for GC. +genetics_overexpression_promote 30902389 hsa-mir-365 Carcinoma, Non-Small-Cell Lung Here we reveal that overexpression of miR-365 is able to enhance the radiosensitivity of NSCLC cells through targeting CDC25A. +lncRNA target 30901819 hsa-mir-396g Leukemia, Myeloid Among them, miR319, miR171, and miR396g-5p were confirmed via 5'-RACE and qRT-PCR to target a myeloblastosis (MYB) transcription factor gene, a SCARECROW-like protein gene, and a cation transporting ATPase gene, respectively. +lncRNA target 30901819 hsa-mir-319 Leukemia, Myeloid Among them, miR319, miR171, and miR396g-5p were confirmed via 5'-RACE and qRT-PCR to target a myeloblastosis (MYB) transcription factor gene, a SCARECROW-like protein gene, and a cation transporting ATPase gene, respectively. +lncRNA target 30901819 hsa-mir-171 Leukemia, Myeloid Among them, miR319, miR171, and miR396g-5p were confirmed via 5'-RACE and qRT-PCR to target a myeloblastosis (MYB) transcription factor gene, a SCARECROW-like protein gene, and a cation transporting ATPase gene, respectively. +lncRNA target 30901819 hsa-mir-171i Leukemia, Myeloid Among them, miR319, miR171, and miR396g-5p were confirmed via 5'-RACE and qRT-PCR to target a myeloblastosis (MYB) transcription factor gene, a SCARECROW-like protein gene, and a cation transporting ATPase gene, respectively. +genetics_overexpression_suppress 30901579 hsa-mir-26b Fibrosis Microarray analysis revealed that miR-26b-5p overexpression affected a list of genes associated with fibrosis and angiogenesis. +genetics_knock down_promote 30901121 hsa-mir-760 Carcinoma, Non-Small-Cell Lung Knockdown of miR +genetics_knock down_promote 30901121 hsa-mir-155 Carcinoma, Non-Small-Cell Lung Knockdown of miR +other 30900865 hsa-mir-21 Breast Neoplasms This method enables the sensitive and rapid detection of miR-21 in human breast cancer cells within 30 min with a detection limit of 2.33 fM. +lncRNA target 30900425 hsa-mir-130a Osteoarthritis CONCLUSION: LncRNA H19 aggravated the injury of LPS-induced C28/I2 cells by sponging miR-130a, hinting a novel regulatory mechanism and a potential therapeutic target for OA. +lncRNA target 30900421 hsa-mir-145 Acute Aortic Dissection CONCLUSION: miR-145 suppressed the progression of AAD by targeting CTGF, suggesting that a miR-145/CTGF axis may provide a potential therapeutic target for AAD. +lncRNA target 30900419 hsa-mir-34a Nasopharyngeal Carcinoma CONCLUSION: Our study demonstrated that NEAT1 targets miR-34a-5p at least partly to drive NPC progression by regulating Wnt/beta-catenin signaling, suggesting a potential therapeutic target for NPC. +transcription factor target 30900402 hsa-mir-194 Carcinoma, Non-Small-Cell Lung miR-194 was significantly downregulated in non-small cell lung cancer (NSCLC) cells cultured in high glucose (HG) medium and clinical NSCLC tissues with DM. Therapeutically, miR-194 may serve as a potential target for the treatment of lung cancer patients with DM. +lncRNA target 30900118 hsa-mir-181a Brain Injuries, Traumatic These results suggest that miR-181a inhibition may be a therapeutic approach to reduce hippocampal excitotoxicity and prevent cognitive dysfunction following mTBI. +genetics_overexpression_suppress 30899394 hsa-mir-139 Colorectal Neoplasms HCP5 overexpression and of miR +lncRNA target 30899380 hsa-mir-155 Stomach Neoplasms c-Myc signaling and may serve as a novel therapeutic target for treatment of patients with GC. +genetics_overexpression_promote 30899377 hsa-mir-184 Carcinoma, Endometrioid In vitro assays, overexpression of miR-184 could suppress the proliferation and invasion of HEC-1B and RL95-2 cells. +genetics_overexpression_suppress 30899305 hsa-mir-129 Ovarian Neoplasms 5p overexpression can effectively attenuate the effects of PCAT-1 on the proliferation and apoptosis of OC cells. +other 30899304 hsa-mir-181d Glioblastoma MATERIAL AND METHODS: In 49 GB patients, we analyzed the possible associations between TP53 and its miRNA regulators miR-125b, miR-21, and miR-34a, as well as MGMT and its miRNA regulators miR-181d and miR-648. +other 30899304 hsa-mir-21 Glioblastoma MATERIAL AND METHODS: In 49 GB patients, we analyzed the possible associations between TP53 and its miRNA regulators miR-125b, miR-21, and miR-34a, as well as MGMT and its miRNA regulators miR-181d and miR-648. +other 30899304 hsa-mir-648 Glioblastoma MATERIAL AND METHODS: In 49 GB patients, we analyzed the possible associations between TP53 and its miRNA regulators miR-125b, miR-21, and miR-34a, as well as MGMT and its miRNA regulators miR-181d and miR-648. +other 30899304 hsa-mir-34a Glioblastoma MATERIAL AND METHODS: In 49 GB patients, we analyzed the possible associations between TP53 and its miRNA regulators miR-125b, miR-21, and miR-34a, as well as MGMT and its miRNA regulators miR-181d and miR-648. +other 30899304 hsa-mir-125b Glioblastoma MATERIAL AND METHODS: In 49 GB patients, we analyzed the possible associations between TP53 and its miRNA regulators miR-125b, miR-21, and miR-34a, as well as MGMT and its miRNA regulators miR-181d and miR-648. +circulation_biomarker_diagnosis_up 30899290 hsa-mir-133a Cardiomyopathy, Dilated, with Left Ventricular Noncompaction The purpose of the study was to assess the miRNAs well established in myocardial fibrosis - miR-21, miR-29a, miR-30d and miR-133a - in the plasma of patients with left ventricular non-compaction (LVNC) that have areas of LGE assessed by CMR. CONCLUSIONS: The up-regulation of miR-21, miR-29a, miR-30d and miR-133a indicates the presence of LGE in LVNC patients, and therefore they may serve as potential biomarkers for myocardial fibrosis. +circulation_biomarker_diagnosis_up 30899290 hsa-mir-21 Cardiomyopathy, Dilated, with Left Ventricular Noncompaction The purpose of the study was to assess the miRNAs well established in myocardial fibrosis - miR-21, miR-29a, miR-30d and miR-133a - in the plasma of patients with left ventricular non-compaction (LVNC) that have areas of LGE assessed by CMR. CONCLUSIONS: The up-regulation of miR-21, miR-29a, miR-30d and miR-133a indicates the presence of LGE in LVNC patients, and therefore they may serve as potential biomarkers for myocardial fibrosis. +circulation_biomarker_diagnosis_up 30899290 hsa-mir-29a Cardiomyopathy, Dilated, with Left Ventricular Noncompaction The purpose of the study was to assess the miRNAs well established in myocardial fibrosis - miR-21, miR-29a, miR-30d and miR-133a - in the plasma of patients with left ventricular non-compaction (LVNC) that have areas of LGE assessed by CMR. CONCLUSIONS: The up-regulation of miR-21, miR-29a, miR-30d and miR-133a indicates the presence of LGE in LVNC patients, and therefore they may serve as potential biomarkers for myocardial fibrosis. +lncRNA target 30899277 hsa-mir-9 Prostatic Neoplasms 5p suppresses prostate cancer progress by targeting StarD13. +other 30898716 hsa-mir-26b Nasopharyngeal Carcinoma Rescue assay was conducting to further confirm that LINC00520 contributed to NPC progression by regulating miR-26b-3p/ubiquitin-specific protease 39 (USP39) signal pathway. +other 30898707 hsa-mir-921 Lung Neoplasms In this study, we assessed the role of the microRNA (miRNA) hsa-miR-921 (miR-921) in the regulation of GPx3 expression in A549 lung cancer cells. +other 30898707 hsa-mir-921 Adenocarcinoma of Lung In this study, we assessed the role of the microRNA (miRNA) hsa-miR-921 (miR-921) in the regulation of GPx3 expression in A549 lung cancer cells. +lncRNA target 30898696 hsa-mir-455 Hypoxia Suppression of long noncoding RNA TTTY15 attenuates hypoxia-induced cardiomyocytes injury by targeting miR5p. +transcription factor target 30898695 hsa-mir-181b-1 Ossification, Heterotopic These findings have important implications for the design of miR-181a/b targeting strategies to treat bone conditions such as fractures or heterotopic ossification. +transcription factor target 30898695 hsa-mir-181b-1 Fractures, Bone These findings have important implications for the design of miR-181a/b targeting strategies to treat bone conditions such as fractures or heterotopic ossification. +transcription factor target 30898695 hsa-mir-181b-1 Bone Diseases These findings have important implications for the design of miR-181a/b targeting strategies to treat bone conditions such as fractures or heterotopic ossification. +other 30898695 hsa-mir-181a-1 Hyperostosis Specifically, we found that miR-181a-1 was significantly more highly expressed in hypertrophic chondrocytes compared to proliferating differentiated or progenitor chondrocytes, suggesting a potential role in regulating chondrocyte hypertrophy and/or endochondral bone formation. +other 30898647 hsa-mir-195 Lymphoma, Large B-Cell, Diffuse RESULTS MALAT1, PD-L1 and CD8 were up-regulated in DLBCL tissues while miR-195 was down-regulated. CONCLUSION Long non-coding RNA MALAT1 sponged miR-195 to regulate proliferation, apoptosis and migration and immune escape abilities of DLBCL by regulation of PD-L1. +lncRNA target 30898623 hsa-mir-155 Aortic Aneurysm, Abdominal 5p can regulate the viability and apoptosis of VSMCs to trigger the progression of AAA. +genetics_overexpression_promote 30898548 hsa-mir-101 Carcinoma, Hepatocellular The inhibition of HCC progression by miR-101 was counteracted by ZNF217 overexpression. +genetics_knock down_promote 30898507 hsa-mir-7 Pancreatic Carcinoma Furthermore, ciRS-7 knockdown suppressed cell proliferation and invasion of PDAC cells (P < 0.05), and the downregulation of ciRS-7 resulted in miR-7 overexpression and subsequent inhibition of epidermal growth factor receptor (EGFR) and signal transducer and activator of transcription 3 (STAT3). +genetics_overexpression_promote 30898167 hsa-mir-155 Glioblastoma CONCLUSION: Our results demonstrated that overexpressed miR155HG in GBM can sponge miR-185 to promote ANXA2 expression, and ANXA2 stimulates miR155HG level through phosphorylated STAT3 binding to the miR155HG promoter. +transcription factor target 30898137 hsa-mir-17 Multiple Myeloma Mechanistically, this effect was linked to trabectedin-induced inhibition of NKG2D-ligands negative regulators IRF4 and IKZF1, as well as to miR-17 family downregulation in MM cells. +circulation_biomarker_diagnosis_up 30898038 hsa-mir-423 Tuberculosis, Pulmonary 5p was found in peripheral blood mononuclear cells of patients with tuberculosis. +circulation_biomarker_diagnosis_up 30898038 hsa-mir-423 Tuberculosis 5p was found in peripheral blood mononuclear cells of patients with tuberculosis. +circulation_biomarker_diagnosis_ns 30897881 hsa-mir-29a Hypertrophy, Left Ventricular After adjustment for gender, age, systolic blood pressure, diastolic blood pressure, body mass index, hypertension duration, antihypertensive drugs, multiple regression analysis showed that there were still positive correlations between plasma miRNA-29a level and IVSd (beta=0.535, P<0.01), LVPWTd (beta=0.085, P<0.01), and LVMI (beta=0.806, P<0.01). +genetics_overexpression_promote 30897321 hsa-mir-186 Osteosarcoma 5p overexpression also inhibited the epithelial-tomesenchymal transition (EMT), migration and invasion of OS cells. +genetics_overexpression_suppress 30897301 hsa-mir-26a Multiple Myeloma In contrast, overexpression of CDK6 decreased the effect of miR-26a mimic on MM cell survival. +other 30897084 hsa-mir-548f-1 Heart Septal Defects, Ventricular In addition, we identified 8 microRNAs that have the potential to be biomarkers for the detection of VSD including: miR-191, miR-548F1, miR-148A, miR-423, miR-92B, miR-611, miR-2110, and miR-548H4. +other 30897084 hsa-mir-191 Heart Septal Defects, Ventricular In addition, we identified 8 microRNAs that have the potential to be biomarkers for the detection of VSD including: miR-191, miR-548F1, miR-148A, miR-423, miR-92B, miR-611, miR-2110, and miR-548H4. +other 30897084 hsa-mir-92b Heart Septal Defects, Ventricular In addition, we identified 8 microRNAs that have the potential to be biomarkers for the detection of VSD including: miR-191, miR-548F1, miR-148A, miR-423, miR-92B, miR-611, miR-2110, and miR-548H4. +other 30897084 hsa-mir-611 Heart Septal Defects, Ventricular In addition, we identified 8 microRNAs that have the potential to be biomarkers for the detection of VSD including: miR-191, miR-548F1, miR-148A, miR-423, miR-92B, miR-611, miR-2110, and miR-548H4. +other 30897084 hsa-mir-5484 Heart Defects, Congenital In addition, we identified 8 microRNAs that have the potential to be biomarkers for the detection of VSD including: miR-191, miR-548F1, miR-148A, miR-423, miR-92B, miR-611, miR-2110, and miR-548H4. +other 30897084 hsa-mir-2110 Heart Septal Defects, Ventricular In addition, we identified 8 microRNAs that have the potential to be biomarkers for the detection of VSD including: miR-191, miR-548F1, miR-148A, miR-423, miR-92B, miR-611, miR-2110, and miR-548H4. +other 30897084 hsa-mir-5484 Heart Septal Defects, Ventricular In addition, we identified 8 microRNAs that have the potential to be biomarkers for the detection of VSD including: miR-191, miR-548F1, miR-148A, miR-423, miR-92B, miR-611, miR-2110, and miR-548H4. +other 30897084 hsa-mir-92b Heart Defects, Congenital In addition, we identified 8 microRNAs that have the potential to be biomarkers for the detection of VSD including: miR-191, miR-548F1, miR-148A, miR-423, miR-92B, miR-611, miR-2110, and miR-548H4. +other 30897084 hsa-mir-191 Heart Defects, Congenital In addition, we identified 8 microRNAs that have the potential to be biomarkers for the detection of VSD including: miR-191, miR-548F1, miR-148A, miR-423, miR-92B, miR-611, miR-2110, and miR-548H4. +other 30897084 hsa-mir-2110 Heart Defects, Congenital In addition, we identified 8 microRNAs that have the potential to be biomarkers for the detection of VSD including: miR-191, miR-548F1, miR-148A, miR-423, miR-92B, miR-611, miR-2110, and miR-548H4. +other 30897084 hsa-mir-423 Heart Defects, Congenital In addition, we identified 8 microRNAs that have the potential to be biomarkers for the detection of VSD including: miR-191, miR-548F1, miR-148A, miR-423, miR-92B, miR-611, miR-2110, and miR-548H4. +other 30897084 hsa-mir-423 Heart Septal Defects, Ventricular In addition, we identified 8 microRNAs that have the potential to be biomarkers for the detection of VSD including: miR-191, miR-548F1, miR-148A, miR-423, miR-92B, miR-611, miR-2110, and miR-548H4. +other 30897084 hsa-mir-548f-1 Heart Defects, Congenital In addition, we identified 8 microRNAs that have the potential to be biomarkers for the detection of VSD including: miR-191, miR-548F1, miR-148A, miR-423, miR-92B, miR-611, miR-2110, and miR-548H4. +other 30897084 hsa-mir-611 Heart Defects, Congenital In addition, we identified 8 microRNAs that have the potential to be biomarkers for the detection of VSD including: miR-191, miR-548F1, miR-148A, miR-423, miR-92B, miR-611, miR-2110, and miR-548H4. +genetics_overexpression_promote 30896885 hsa-mir-183 Colorectal Neoplasms miR1835p downregulation or overexpression regulated the CRC cell cycle, invasion and migration by modulating RCN2 expression. +lncRNA target 30896881 hsa-mir-132 Hypertension, Pulmonary Taken collectively, the data suggested that miR132 regulated PASMC function via PTEN and that it may be used as a potential target for the treatment of PAH. +lncRNA target 30896880 hsa-mir-663b Urinary Bladder Neoplasms In conclusion, inhibition of miR663b reduced viability and induced apoptosis in bladder cancer cells by targeting TUSC2. +lncRNA target 30896877 hsa-mir-363 Osteosarcoma The present data demonstrated that downregulation of the tumor suppressor miR-363 may be involved in the development of osteosarcoma via regulation of PDZD2. +genetics_overexpression_suppress 30896868 hsa-mir-215 Carcinoma, Hepatocellular Following overexpression of miR215 in the H4IIE rat hepatocarcinoma cell line, it was reported that the intracellular insulin signalling pathway was inhibited; conversely, inhibition of miR215 expression induced this pathway. +transcription factor target 30896864 hsa-mir-218 Uterine Cervical Neoplasms Furthermore, silencing HOXA1 reversed the effects of the miR218 inhibitor on CC cells. +lncRNA target 30896854 hsa-let-7a Diabetic Nephropathies Let7a5p was downregulated in DN and may participate in the pathogenesis of DN via regulating HMGA2 expression and the PI3KAKT signaling pathway. +other 30896849 hsa-mir-29b Fibrosis These results highlight an important role of miR29b in the AST modulating LX2 cells proliferation and apoptosis and implicate a potential mechanism of miR29b and AST preventing liver fibrosis. +lncRNA target 30896848 hsa-mir-214 Burns The results of the present study indicated the association between the dysregulation of MALAT1/miR214/TLR5 and the risk of postburn sepsis. +lncRNA target 30896848 hsa-mir-214 Sepsis The results of the present study indicated the association between the dysregulation of MALAT1/miR214/TLR5 and the risk of postburn sepsis. +lncRNA target 30896844 hsa-mir-661 Carcinoma, Non-Small-Cell Lung In the present study, it was demonstrated that the expression of microRNA, hsamiR6613p, was downregulated and UbcH10 was upregulated in 12 pairs of NSCLC tumors and three NSCLC cell lines. Collectively, our results indicated that downregulation of hsamiR6613p was involved in NSCLC and restoration of hsamiR6613p impaired the growth of NSCLC cell lines A549 and SKMES1, suggesting that hsamiR6613p may be a potential target molecule for the therapy of NSCLC. +genetics_overexpression_promote 30896820 hsa-mir-9 Prostatic Neoplasms Furthermore, it was demonstrated that the 3'untranslated region of MEKK3 was a target of miR9, and that MEKK3 overexpression prevented the inhibitory effects of miR9 on the viability, migration and invasion of PC cells. +genetics_overexpression_promote 30896817 hsa-mir-512 Carcinoma, Non-Small-Cell Lung Then, the proliferation, migration, invasion and apoptosis in NSCLC A549 and H1299 cell lines were detected when miR5125p was overexpressed. +transcription factor target 30896808 hsa-mir-153 Neurotoxicity Syndromes The results of the present study suggested the function of miRNA153 against neurotoxicity via Nrf2/AREmediated cytoprotection. +transcription factor target 30896796 hsa-mir-1 Myocardial Infarction The expression of heat shock protein 60 (HSP60), a direct target of miR1, was identified to be decreased in MI and H2O2induced apoptosis, which was associated with a decrease in Bcl2 and an increase in Bax; expression was restored following treatment with carvedilol. +lncRNA target 30896795 hsa-mir-124 Triple Negative Breast Neoplasms These data demonstrate that miR124 serves vital roles in the suppression of triplenegative breast cancer via inhibition of cell proliferation and invasion through STAT3. +exosome 30896790 hsa-mir-8485 Precancerous Conditions Therefore, the present study highlights the significance of MSCderived exosomes and exosomal miR8485 in premalignant lesions and carcinogenesis. +other 30896786 hsa-mir-130a Diabetic Angiopathies The effects of metformin on improving PAinduced EPC dysfunction are mediated by miR130a and PTEN, which may assist in the prevention and/or treatment of diabetic vascular disease. +genetics_GWAS 30895838 hsa-mir-122 Ischemic Stroke The aim of this study was to clarify whether genetic variations in four miRNA genes (miR-143 rs4705342, miR-122 rs17669, miR-126 rs4636297, and miR-124 rs531564) contribute to IS susceptibility. However, the three other miRNA (miR-143 rs4705342, miR-122 rs17669, and miR-124 r531564) were not associated with IS risk under allele or genotype, nor in different inheritance models. +genetics_GWAS 30895838 hsa-mir-124 Ischemic Stroke The aim of this study was to clarify whether genetic variations in four miRNA genes (miR-143 rs4705342, miR-122 rs17669, miR-126 rs4636297, and miR-124 rs531564) contribute to IS susceptibility. However, the three other miRNA (miR-143 rs4705342, miR-122 rs17669, and miR-124 r531564) were not associated with IS risk under allele or genotype, nor in different inheritance models. +genetics_GWAS 30895838 hsa-mir-126 Ischemic Stroke Results: The miR-126 gene rs4636297 polymorphism was associated with decreased small vessel stroke risk (GA vs. Conclusion: Our study suggests that the miR-126 gene rs4636297 polymorphism may play an important role in the pathogenesis of small vessel occlusive stroke in the northern Chinese Han population. +genetics_GWAS 30895838 hsa-mir-143 Ischemic Stroke The aim of this study was to clarify whether genetic variations in four miRNA genes (miR-143 rs4705342, miR-122 rs17669, miR-126 rs4636297, and miR-124 rs531564) contribute to IS susceptibility. However, the three other miRNA (miR-143 rs4705342, miR-122 rs17669, and miR-124 r531564) were not associated with IS risk under allele or genotype, nor in different inheritance models. +other 30895711 hsa-mir-150 Demyelinating Diseases Mysm1-deficient ASCs also showed depressed miR-150 expression. Furthermore, Mysm1-deficient cells transduced with lentivirus containing miR-150 mimics produced less pro-inflammatory factors and more NO. +circulation_biomarker_diagnosis_ns 30895441 hsa-mir-15a Multiple Sclerosis 5p) in the peripheral blood of MS patients compared with healthy subjects in association with response to fingolimod treatment. +circulation_biomarker_diagnosis_ns 30895441 hsa-mir-501 Multiple Sclerosis 5p) in the peripheral blood of MS patients compared with healthy subjects in association with response to fingolimod treatment. +circulation_biomarker_diagnosis_ns 30895441 hsa-mir-204 Multiple Sclerosis 5p) in the peripheral blood of MS patients compared with healthy subjects in association with response to fingolimod treatment. +circulation_biomarker_diagnosis_ns 30895441 hsa-mir-524 Multiple Sclerosis 5p) in the peripheral blood of MS patients compared with healthy subjects in association with response to fingolimod treatment. +circulation_biomarker_diagnosis_ns 30895441 hsa-mir-96 Multiple Sclerosis 5p) in the peripheral blood of MS patients compared with healthy subjects in association with response to fingolimod treatment. +lncRNA target 30894370 hsa-mir-28 Ovarian Neoplasms SIGNIFICANCE: These findings present inhibition of miR-328 as a novel strategy for efficient elimination of CSC to prevent tumor metastasis and recurrence in patients with epithelial ovarian cancer. +transcription factor target 30894209 hsa-mir-191 Arthritis, Rheumatoid We observed that miR-191 in RA-FLS increased cellular proliferation via promoting G(1)/S transition of the cell cycle and suppressed cell apoptosis induced by cell starvation. +lncRNA target 30894138 hsa-mir-128 Atrial Fibrillation CONCLUSION: LncRNA PVT1 promotes atrial fibrosis via miR +lncRNA target 30894138 hsa-mir-128 Fibrosis, Atrial CONCLUSION: LncRNA PVT1 promotes atrial fibrosis via miR +genetics_overexpression_promote 30893332 hsa-mir-450a Squamous Cell Carcinoma of Head and Neck Overexpression of miR-450a in OSCC cells impaired cell adhesion ability and induced invasiveness, which demonstrated the functional role of miR-450a as an onco-miRNA. +lncRNA target 30891870 hsa-mir-340 Hepatitis B, Chronic Notably, ATF7 is upregulated in HCC tissue, suggesting that HBV may target miR +lncRNA target 30891870 hsa-mir-340 Liver Neoplasms Notably, ATF7 is upregulated in HCC tissue, suggesting that HBV may target miR +lncRNA target 30891826 hsa-mir-558 Pre-Eclampsia The expression level of miR-558 in the PE group was significantly lower than the control group, and the expression level of Linc00261 was negatively correlated with the expression level of miR-558 in the placental tissues of women with PE. The mechanistic results indicated that Linc00261 exerted the suppressive effects on the trophoblast invasion and migration via targeting miR-558/TIMP4 axis, which may involve in the pathogenesis of PE. +other 30891809 hsa-mir-374a Esophageal Squamous Cell Carcinoma tumor necrosis factor receptor superfamily member 10A (NFRSF10A) were identified to play key roles in the metastasis of ESCC. +other 30891809 hsa-mir-222 Esophageal Squamous Cell Carcinoma tumor necrosis factor receptor superfamily member 10A (NFRSF10A) were identified to play key roles in the metastasis of ESCC. +other 30891809 hsa-mir-30 Esophageal Squamous Cell Carcinoma tumor necrosis factor receptor superfamily member 10A (NFRSF10A) were identified to play key roles in the metastasis of ESCC. +other 30891745 hsa-mir-29b Anemia, Sickle Cell We subsequently, observed higher MIR29B expression in SCD patients with higher HbF levels compared to those with low HbF. Our findings provide evidence for the ability of MIR29B to induce HbF and supports further investigation to expand treatment options for SCD. +other 30891745 hsa-mir-29 Anemia, Sickle Cell We subsequently, observed higher MIR29B expression in SCD patients with higher HbF levels compared to those with low HbF. Our findings provide evidence for the ability of MIR29B to induce HbF and supports further investigation to expand treatment options for SCD. +circulation_biomarker_diagnosis_ns 30891618 hsa-mir-203 Multiple Myeloma miR-203 showed significant correlation with myeloma-associated parameters and also showed optimum sensitivity and specificity for diagnosis of MM in serum. Correlation of miR-203 with myeloma clinical parameters along with optimum sensitivity and specificity affirms its non-invasive diagnostic potential in MM which could further be validated in larger patient cohort. +circulation_biomarker_diagnosis_ns 30891102 hsa-mir-145 Breast Neoplasms Presence of Circulating miR-145, miR-155, and miR-382 in Exosomes Isolated from Serum of Breast Cancer Patients and Healthy Donors. +circulation_biomarker_diagnosis_ns 30891102 hsa-mir-155 Breast Neoplasms Presence of Circulating miR-145, miR-155, and miR-382 in Exosomes Isolated from Serum of Breast Cancer Patients and Healthy Donors. +circulation_biomarker_diagnosis_ns 30891102 hsa-mir-382 Breast Neoplasms Presence of Circulating miR-145, miR-155, and miR-382 in Exosomes Isolated from Serum of Breast Cancer Patients and Healthy Donors. +transcription factor target 30891072 hsa-mir-221 Carcinoma, Squamous Cell, Cutaneous CONCLUSIONS: Taken together, the obtained results indicated that miR-221 plays an oncogenic function in CSCC by targeting PTEN and further suggest that miR-221 may be a potential target for CSCC diagnosis and treatment. +exosome 30890521 hsa-mir-340 Gynatresia These data suggest that the effective antifibrotic function of BMSCs is able to transfer miR-340 to ESCs by exosomes, and that enhancing the transfer of BMSC-derived miR-340 is an alternative modality in preventing intrauterine adhesion. +genetics_overexpression_promote 30890500 hsa-mir-593 Colonic Neoplasms The cell proliferation assay showed opposite effects of miR-593 and PLK1 on the proliferation of colon cancer cells, and the effect of co-transfection with miR-593 mimic and a PLK1-overexpressing plasmid on the cell proliferation was between those in PLK1 over-expressing group and miR-593 mimic group. +circRNA target 30890428 hsa-mir-200b Liver Cirrhosis Melatonin, a neuroendocrine hormone synthesized by the pineal gland and cholangiocytes, decreases biliary hyperplasia and liver fibrosis during cholestasis-induced biliary injury via melatonin-dependent autocrine signaling through increased biliary arylalkylamine N-acetyltransferase (AANAT) expression and melatonin secretion, downregulation of miR-200b and specific circadian clock genes. +circRNA target 30890428 hsa-mir-200b Cholestasis Melatonin, a neuroendocrine hormone synthesized by the pineal gland and cholangiocytes, decreases biliary hyperplasia and liver fibrosis during cholestasis-induced biliary injury via melatonin-dependent autocrine signaling through increased biliary arylalkylamine N-acetyltransferase (AANAT) expression and melatonin secretion, downregulation of miR-200b and specific circadian clock genes. +other 30890403 hsa-mir-222 Thyroid Cancer, Papillary MiR-222, -137 and -181b showed an association with the degree of malignancy in PTC tumors. +lncRNA target 30890278 hsa-mir-374a Pancreatic Carcinoma Therefore, this study revealed that miR-374a promoted cell proliferation, migration and EMT via targeting SRCIN1 in pancreatic cancer. +genetics_overexpression_promote 30890138 hsa-mir-92a Glioma Repression of miR-92a was observed in Swainsonine-treated cells, and miR-92a overexpression overturned the anti-tumor activity of Swainsonine in glioma cells. CONCLUSIONS: These discoveries corroborated that Swainsonine exerted anti-tumor impacts on glioma cells via repression of miR-92a, and inactivation of PI3K/AKT/mTOR signaling pathway. +exosome 30889706 hsa-mir-675 Vascular Diseases Taken together, this study identified miR-675 as an important regulator of cell senescence and provided a novel strategy to deliver powerful exosomes by silk fibroin hydrogel to treat aging-induced vascular dysfunction. +circulation_biomarker_diagnosis_ns 30889506 hsa-mir-501 Chronic Periodontitis 3p are candidate serum biomarkers for chronic periodontitis. +circulation_biomarker_diagnosis_ns 30889506 hsa-mir-21 Chronic Periodontitis 3p are candidate serum biomarkers for chronic periodontitis. +circulation_biomarker_diagnosis_ns 30889506 hsa-mir-664a Chronic Periodontitis 3p are candidate serum biomarkers for chronic periodontitis. +transcription factor target 30889489 hsa-mir-196b Hydatidiform Mole miR-196b and MAP3K1 may be considered potential targets for the clinical treatment of HM. +other 30889053 hsa-mir-150 Melanoma In summary, we confirmed the tumor-promoting role of ZFAS1 in melanoma and provide evidence for the role and mechanism of the ZFAS1/miR5p/RAB9A axis. +lncRNA target 30888602 hsa-mir-200a Peritoneal Fibrosis Furthermore, we demonstrated that miR-200a inhibition of PF in vivo was associated with the suppression of ZEB1 and 2, which were proved to be the target of miR-200a in our previous study. +lncRNA target 30888162 hsa-mir-129 Colonic Neoplasms 3p/Pirh2/p53 is a critical signaling pathway in AVN A induced cellular senescence and AVN A could be a potential chemopreventive strategy for cancer treatment. +genetics_overexpression_promote 30888082 hsa-mir-19a Glioblastoma AC016405.3 was revealed as a target of miR-19a-5p, and overexpression of miR-19a-5p reversed the inhibitive effect of AC016405.3 on GBM cell proliferation and metastasis. +circulation_biomarker_prognosis_ns 30887897 hsa-mir-1290 Squamous Cell Carcinoma of Head and Neck The expression level of miR-1290 was significantly lower in the plasma of oral squamous cell carcinoma patients than in that of healthy volunteers (p < 0.01). +circulation_biomarker_diagnosis_ns 30887716 hsa-mir-101 Neuralgia We found miR-101 level was significantly repressed in both the plasma samples and sural nerve biopsies from neuropathic pain patients. The negative correlation between miR-101 and KPNB1 was also confirmed in the sural nerve biopsies, and miR-101 reduction relates to the activation of NF-kappaB signaling in vivo and in vitro which contributes to the pathogenesis of neuropathic pain. +other 30887698 hsa-mir-942 Ovarian Neoplasms In summary, circEPSTI1 regulated EPSTI1 expression and ovarian cancer progression by sponging miR-942. +other 30887657 hsa-mir-371 Glioma In addition, it is also found that FER1L4 can be used as competitive endogenous RNA to interact or bind with miR-371 and thereby up-regulate E2F1, thus promoting the cycle and proliferation of glioma cells. +other 30887601 hsa-mir-22 Osteoarthritis RESULTS: The lncRNA-TM1P3 significantly upregulated in patients with OA, accompanied by the downregulation of miR-22 and upregulation of pSMAD1/5 and MMP13, which ultimately resulted in the degradation of the chondrocyte ECM in patients with OA. CONCLUSIONS: These findings demonstrated that the lncRNA-TM1P3/miR-22/TGF-beta signaling/MMP13 axis is involved in the degradation of chondrocyte ECM in patients with OA, which could provide novel therapies for OA treatment. +other 30887564 hsa-mir-146 Thyroid Neoplasms CONCLUSIONS: Elevated miR-222 and miR-146 levels are associated with poorer outcomes of the disease and may have a prognostic value in the management and follow-up of DTC. +other 30887564 hsa-mir-222 Thyroid Neoplasms miR-222 was twofold to threefold higher in tall cell papillary carcinomas (P = 0.038). +genetics_knock down_suppress 30887508 hsa-mir-29 Bile Duct Neoplasms The role miR-329 played in BDC was examined using gain-of-function and loss-of-function methods. +genetics_overexpression_promote 30887246 hsa-mir-138 Alzheimer Disease Overexpression of sirtuin 1 (Sirt1), a target of miR-138, ameliorated the miR +other 30886860 hsa-mir-9-1 Myocardial Infarction 1 were identified as potential candidate regulators in acute myocardial infarction. +other 30886860 hsa-mir-124 Myocardial Infarction 1 were identified as potential candidate regulators in acute myocardial infarction. +other 30886860 hsa-let-7b Myocardial Infarction 1 were identified as potential candidate regulators in acute myocardial infarction. +other 30886860 hsa-let-7d Myocardial Infarction 1 were identified as potential candidate regulators in acute myocardial infarction. +lncRNA target 30886803 hsa-mir-122 Liver Cirrhosis Consequently, the HSC-targeted combination therapy with miRNA-29b and miRNA-122 demonstrates a prominent antifibrotic efficacy in terms of improving liver function and relieving hepatic fibrosis. +lncRNA target 30886803 hsa-mir-29b Liver Cirrhosis Consequently, the HSC-targeted combination therapy with miRNA-29b and miRNA-122 demonstrates a prominent antifibrotic efficacy in terms of improving liver function and relieving hepatic fibrosis. +genetics_overexpression_promote 30886656 hsa-mir-224 Triple Negative Breast Neoplasms In this study, miR-224 was overexpressed in breast cancer cell lines and TNBC primary cancer samples. Our findings have demonstrated that the miR-224/CASP9 axis plays an important role in TNBC progression, providing evidence in support of a promising therapeutic strategy for this disease. +circulation_biomarker_diagnosis_ns 30886653 hsa-mir-425 Tuberculosis, Pulmonary RESULTS: The expression of miR-484, miR-425, and miR-96 were significantly increased in serum of TB patients which correlated with the TB infection level. +circulation_biomarker_diagnosis_ns 30886653 hsa-mir-96 Tuberculosis, Pulmonary RESULTS: The expression of miR-484, miR-425, and miR-96 were significantly increased in serum of TB patients which correlated with the TB infection level. +circulation_biomarker_diagnosis_ns 30886653 hsa-mir-484 Tuberculosis, Pulmonary RESULTS: The expression of miR-484, miR-425, and miR-96 were significantly increased in serum of TB patients which correlated with the TB infection level. +other 30886579 hsa-mir-337 Squamous Cell Carcinoma of Head and Neck Furthermore, some miRNAs (hsa-mir-99a, hsa-mir-337, and hsa-mir-137) and mRNAs (NOSTRIN, TIMP4, GRB14, HOXB9, CELSR3, and ADGRD2) may be the prognostic genes of HNSCC. +other 30886579 hsa-mir-137 Squamous Cell Carcinoma of Head and Neck Furthermore, some miRNAs (hsa-mir-99a, hsa-mir-337, and hsa-mir-137) and mRNAs (NOSTRIN, TIMP4, GRB14, HOXB9, CELSR3, and ADGRD2) may be the prognostic genes of HNSCC. +other 30886579 hsa-mir-99a Squamous Cell Carcinoma of Head and Neck Furthermore, some miRNAs (hsa-mir-99a, hsa-mir-337, and hsa-mir-137) and mRNAs (NOSTRIN, TIMP4, GRB14, HOXB9, CELSR3, and ADGRD2) may be the prognostic genes of HNSCC. +genetics_GWAS 30886246 hsa-let-7a Enterovirus Infections A miRNA-based vaccine strain (pIY) carrying let-7a and miR-124a target genes in the EV-A71 genome which has a partial deletion in the 5'NTR (11 bp) and G64R mutation (3D(p) degrees (l)) was designed. +genetics_GWAS 30886246 hsa-mir-124a Enterovirus Infections A miRNA-based vaccine strain (pIY) carrying let-7a and miR-124a target genes in the EV-A71 genome which has a partial deletion in the 5'NTR (11 bp) and G64R mutation (3D(p) degrees (l)) was designed. +lncRNA target 30886199 hsa-mir-145 Gallbladder Neoplasms Thus, this study identified GBC patient subgroups and provides new mechanistic insights in the tumor suppressive function of miR +transcription factor target 30886169 hsa-mir-141 Acute Kidney Injury Next, in the early recovery state, exo-miRs (miR-9a, miR-141, miR-200a, miR-200c, miR-429), which share Zeb1/2 as a common target mRNA, were upregulated together, indicating that they reflect TGF-beta-associated renal fibrosis. +other 30886169 hsa-mir-351 Acute Kidney Injury Finally, release of exo-miRs (miR-125a, miR-351) was regulated by TGF-beta1 and was able to differentiate the sham and IRI even after the injured kidneys were recovered. +transcription factor target 30886169 hsa-mir-200a Acute Kidney Injury Next, in the early recovery state, exo-miRs (miR-9a, miR-141, miR-200a, miR-200c, miR-429), which share Zeb1/2 as a common target mRNA, were upregulated together, indicating that they reflect TGF-beta-associated renal fibrosis. +transcription factor target 30886169 hsa-mir-200c Acute Kidney Injury Next, in the early recovery state, exo-miRs (miR-9a, miR-141, miR-200a, miR-200c, miR-429), which share Zeb1/2 as a common target mRNA, were upregulated together, indicating that they reflect TGF-beta-associated renal fibrosis. +transcription factor target 30886169 hsa-mir-9a Acute Kidney Injury Next, in the early recovery state, exo-miRs (miR-9a, miR-141, miR-200a, miR-200c, miR-429), which share Zeb1/2 as a common target mRNA, were upregulated together, indicating that they reflect TGF-beta-associated renal fibrosis. +other 30886169 hsa-mir-125a Acute Kidney Injury Finally, release of exo-miRs (miR-125a, miR-351) was regulated by TGF-beta1 and was able to differentiate the sham and IRI even after the injured kidneys were recovered. +transcription factor target 30886152 hsa-mir-490 Cholangiocarcinoma 3p at the posttranscriptional level and facilitate CCA cell progression via the IL-6/STAT3/VEGFA signaling pathway. +lncRNA target 30886062 hsa-mir-100 Stomach Neoplasms The study in vitro suggested down-regulation of MIR100HG expression inhibits cell proliferation, migration, and invasion in gastric cancer. +other 30885939 hsa-mir-483 Ehlers-Danlos Syndrome, musculocontractural type 1 Importantly, we found that high expression of MPRL and pre-miR-483, and low expression of miR5p were significantly associated with neoadjuvant chemosensitivity and better TSCC patients' prognosis. +transcription factor target 30885820 hsa-mir-132 Brain Damage, Chronic Taken together, our findings demonstrated that miR-132 protects against CCH-induced learning and memory impairments by down-regulating the expression of Nav1.1 and Nav1.2, and SCN1A and SCN2A are the target genes of miR-132. +lncRNA target 30885433 hsa-mir-107 Ovarian Neoplasms Our finding indicates that miR-107 serves as a tumor suppressor by decreasing CCNE1 expression levels, which may provide potential therapeutic strategies in ovarian cancer treatment. +other 30885035 hsa-mir-33a Thrombocytopenia ROC curve analysis showed that the combination of miR-199a-5p and miR-33a-5p could distinguish patients with ITP from controls with AUC of 0.93.This study identifies a number of differentially expressed miRNAs in ITP patients before and after initiation of TPO-RAs with potential roles in the pathophysiology, as well as with a possible utility as diagnostic and prognostic biomarkers. +other 30885035 hsa-mir-199a Thrombocytopenia ROC curve analysis showed that the combination of miR-199a-5p and miR-33a-5p could distinguish patients with ITP from controls with AUC of 0.93.This study identifies a number of differentially expressed miRNAs in ITP patients before and after initiation of TPO-RAs with potential roles in the pathophysiology, as well as with a possible utility as diagnostic and prognostic biomarkers. +transcription factor target 30884856 hsa-mir-638 limb ischemia After analyzing the miRNOme in CLI-derived hMSC cells and healthy controls, and intersecting the results with the mRNA expression dataset under hypoxic conditions, we identified two miRNAs potentially relevant to the disease: miR-29b as a pathological marker of the disease and miR-638 as a therapeutic target. +transcription factor target 30884856 hsa-mir-29b limb ischemia After analyzing the miRNOme in CLI-derived hMSC cells and healthy controls, and intersecting the results with the mRNA expression dataset under hypoxic conditions, we identified two miRNAs potentially relevant to the disease: miR-29b as a pathological marker of the disease and miR-638 as a therapeutic target. +circulation_biomarker_diagnosis_ns 30884584 hsa-mir-21 Pneumoconiosis Logistic regression model was: logitP=13.769+0.536xmiRNA0.878xmiRNA-200C-0.01 Conclusion: Multiple serum miRNAs combined application models may be used for the diagnosis of pneumoconiosis patients. +other 30884581 hsa-mir-26a Silicotuberculosis Conclusion: The up-regulation of miRNA5p and the down-regulation of miRNA-26a-5p in lung tissues of early silicotic rats may be related to the occurrence and development of early silicosis. +other 30884581 hsa-mir-423 Silicotuberculosis Conclusion: The up-regulation of miRNA5p and the down-regulation of miRNA-26a-5p in lung tissues of early silicotic rats may be related to the occurrence and development of early silicosis. +other 30884187 hsa-mir-181a Uterine Cervical Neoplasms In the present study, RT-PCR showed that the mRNA level of CDKN2B-AS1 was significantly upregulated while the miR-181a-5p was downregulated in cervical cancer cell lines. In summary, our study demonstrated that the CDKN2B-AS1/miR-181a-5p/TGFbetaI axis might play a vital role in cervical cancer development. +genetics_overexpression_promote 30884120 hsa-mir-7 Breast Neoplasms Cells transfected with si-CDR1as or miR-7 mimic had decreased IC50 and colony formation rate, increased expressions of Bax/Bcl2 and cleaved-Caspase-3/Caspase-3, indicating inhibition of CDR1as and overexpression of miR-7 enhances the chemosensitity of 5-FU-resistant BC cells. +lncRNA target 30883979 hsa-mir-664a Stomach Neoplasms CONCLUSION: Taken together, we revealed that miR-664a-3p functions as an oncogene by targeting Hippo pathway in the development of gastric cancer. +other 30883936 hsa-mir-20a Colorectal Neoplasms Taken together, our findings suggest that hypoxia-mediated autophagy was regulated by miR-20a/ATG5/FI200 signaling pathway in CRC. +other 30883865 hsa-let-7 Diabetes Mellitus Our findings suggest that the Lin28/let-7 axis is an important regulator of pancreatic beta-cell functions and that precise modulation of this axis may be helpful in treating metabolic diseases such as diabetes. Taken together, our results imply that the Lin28a/let-7 axis is an important regulator of pancreatic beta-cell functions and that precise modulation of this axis may be helpful in treating metabolic diseases such as diabetes. +transcription factor target 30883744 hsa-mir-145 Reperfusion Injury In conclusion, the essential roles of miR5p and DUSP6 in I/R provide a novel therapeutic target to develop future intervention strategies. +lncRNA target 30883342 hsa-mir-374a Breast Neoplasms MAGI2-AS3 upregulation inhibited breast cancer metastatic progression by decreasing miR-374a and enhancing PTEN expression. +lncRNA target 30883341 hsa-mir-19b Multiple Myeloma Finally, our in vivo experiment demonstrated that lentivirus-mediated delivery of miR-20a promoted tumor growth in murine xenograft model of MM, which provide evidence that miR-20a inhibitor exerts therapeutic activity in preclinical models and supports a framework for the development of miR-19b/20a-based treatment strategies for MM patients. +other 30883340 hsa-mir-424 Colorectal Neoplasms 5p in CRC patients may play an important role in development of CRC and they could function as potential non-invasive biomarkers for CRC. +other 30883339 hsa-mir-223 Squamous Cell Carcinoma of Head and Neck In short, miR-223 promoted OSCC cell proliferation and migration by downregulating FBXW7, which provided a novel therapeutic strategy for OSCC. +lncRNA target 30883336 hsa-mir-337 Uterine Cervical Neoplasms 3p and Rap1A in cervical cancer tissues and normal tissues were evaluated through quantitative Real-time PCR (qRT-PCR) and Western blotting; and correlations of miR +other 30882937 hsa-mir-497 Ischemic Stroke At last, there were 11 lncRNAs were identified in the top three subpathways as hub-lncRNAs totally, including LINC00240, LINC00472, LINC00265, LINC00473, MIR497HG, NEXN-AS1, HCG17, MEG8, EPB41L4A-AS1, SNHG7, and BCYRN1, five of which were validated to be very effective stroke biomarker by RT-PCR. +lncRNA target 30882835 hsa-mir-145 Squamous Cell Carcinoma of Head and Neck 5p nanoparticles significantly suppressed the LSCC progression, indicating their great potential use for cancer therapy. +genetics_overexpression_promote 30881920 hsa-mir-1 Adenocarcinoma of Lung Overexpression of PRC1 reversed the inhibitory effects of miR +genetics_GWAS 30881512 hsa-mir-502 Colorectal Neoplasms binding site polymorphism in the 3'-untranslated region of SET8 with colorectal cancer. +other 30881509 hsa-mir-122 Prostatic Neoplasms It was also demonstrated that miRNA-122 exhibited significantly differential expression and the overall survival rate was predicted for various other types of cancer, including colorectal cancer, renal carcinoma, cholangiocarcinoma, prostate cancer and thyroid carcinoma. +other 30881509 hsa-mir-122 nonpapillary renal cell carcinoma It was also demonstrated that miRNA-122 exhibited significantly differential expression and the overall survival rate was predicted for various other types of cancer, including colorectal cancer, renal carcinoma, cholangiocarcinoma, prostate cancer and thyroid carcinoma. +other 30881509 hsa-mir-122 Colorectal Neoplasms It was also demonstrated that miRNA-122 exhibited significantly differential expression and the overall survival rate was predicted for various other types of cancer, including colorectal cancer, renal carcinoma, cholangiocarcinoma, prostate cancer and thyroid carcinoma. +circulation_biomarker_prognosis_up 30881509 hsa-mir-122 Carcinoma, Hepatocellular First, the reverse transcription-quantitative polymerase chain reaction method was used to detect the expression levels of miRNA-122 in the serum samples of patients with HCC, benign lesions and healthy volunteers. +other 30881509 hsa-mir-122 Thyroid Neoplasms It was also demonstrated that miRNA-122 exhibited significantly differential expression and the overall survival rate was predicted for various other types of cancer, including colorectal cancer, renal carcinoma, cholangiocarcinoma, prostate cancer and thyroid carcinoma. +other 30881509 hsa-mir-122 Cholangiocarcinoma It was also demonstrated that miRNA-122 exhibited significantly differential expression and the overall survival rate was predicted for various other types of cancer, including colorectal cancer, renal carcinoma, cholangiocarcinoma, prostate cancer and thyroid carcinoma. +genetics_overexpression_suppress 30881504 hsa-mir-140 Breast Neoplasms 3p overexpression in BC cell lines, and was inversely correlated with miR +lncRNA target 30881496 hsa-mir-32 Colorectal Neoplasms MicroRNA (miR)-32 upregulation in CRC tissues was previously reported, where it increased the proliferation, migration and invasion, and reduced apoptosis of CRC cells by inhibiting the expression of phosphatase and tensin homolog (PTEN). +other 30881128 hsa-mir-21 Prostatic Neoplasms CONCLUSION: For PCa, miR-21 is a good diagnostic biomarker and miR-30c is a moderate diagnostic biomarker. +circulation_biomarker_diagnosis_ns 30880765 hsa-mir-222 Stomach Neoplasms CONCLUSION: Our results indicated that miR-21 and miR-222 in plasma samples can be served as a potential noninvasive tool in GC detection. +circulation_biomarker_diagnosis_ns 30880765 hsa-mir-21 Stomach Neoplasms CONCLUSION: Our results indicated that miR-21 and miR-222 in plasma samples can be served as a potential noninvasive tool in GC detection. +transcription factor target 30880751 hsa-mir-34a Colorectal Neoplasms In this study, we investigated the potential tumor inhibitory effects of miR-34a alone or in combination with paclitaxel in CRC cells. +genetics_GWAS 30880748 hsa-mir-200c Colorectal Neoplasms In the present study, we have elucidated the role of rs12904, a naturally occurring SNP, in the recognition site of miR200c in the 3'UTR of ephrin A1 ligand gene, in the development of sporadic CRC in the Iranian population. +lncRNA target 30880031 hsa-mir-145 Acute Kidney Injury In conclusion, our study showed that hUC-MSCs enhanced autophagy in AOPP-treated HK-2cells mediated by miR-145 via inhibition of the PI3K/AKT/mTOR pathway, which indicated that hUC-MSCs might serve as a prospective therapy for AKI. +lncRNA target 30879950 hsa-mir-577 Stomach Neoplasms SDPR axis may be a potential prognostic marker and therapeutic target against cancer metastasis in GC. +transcription factor target 30879885 hsa-mir-375 Prostatic Neoplasms Meanwhile, miR-375 may play an important role in aggressive PC by targeting its potential target genes. +lncRNA target 30879766 hsa-mir-149 Carcinoma, Hepatocellular In summary, our findings revealed that LINC00461 is an oncogene in HCC through regulating miR +exosome 30879399 hsa-mir-342 Myocardial Infarction Longterm Exercise-Derived Exosomal miR5p: A Novel Exerkine for Cardioprotection RATIONALE Exercise training, in addition to reducing cardiovascular risk factors, confers direct protection against myocardial ischemia/reperfusion injury and has been associated with improved heart attack survival in humans. +circulation_biomarker_diagnosis_ns 30879399 hsa-mir-342 Myocardial Ischemia CONCLUSIONS Our findings reveal a novel endogenous cardioprotective mechanism that long-term exercise-derived circulating exosomes protect the heart against myocardial ischemia/reperfusion injury via exosomal miR +circulation_biomarker_diagnosis_ns 30879399 hsa-mir-342 Myocardial Reperfusion Injury CONCLUSIONS Our findings reveal a novel endogenous cardioprotective mechanism that long-term exercise-derived circulating exosomes protect the heart against myocardial ischemia/reperfusion injury via exosomal miR +lncRNA target 30878546 hsa-mir-210 Brain Injuries CONCLUSIONS: RCAE attenuated HH-induced brain injury by regulating apoptosis and mitochondrial energy metabolism via the HIF-1alpha/microRNA 210/ISCU1/2 (COX10) signaling pathway. +lncRNA target 30878390 hsa-mir-155 Breast Neoplasms 3p was down-regulated in breast cancer and MYD88 was validated as the target for miR +other 30878364 hsa-mir-125b Ischemic Stroke miR-125b-5p and miR-206 levels are associated with stroke severity. +circulation_biomarker_diagnosis_ns 30878364 hsa-mir-15a Ischemic Stroke MATERIALS AND METHODS: In this prospective cohort study, plasma levels of miR-125b-5p, miR-15a-3p, miR-15a-5p, and miR-206 were measured at 24 hours after thrombolysis with or without endovascular treatment in 94 patients with AIS, as determined by qRT-PCR. +other 30878364 hsa-mir-206 Ischemic Stroke miR-125b-5p and miR-206 levels are associated with stroke severity. +other 30878131 hsa-mir-128b Precursor Cell Lymphoblastic Leukemia-Lymphoma Also, miR-128a, miR-128b, miR-223, let-7b, miR-155 and miR-24 can be used as diagnostic discriminatory biomarkers between ALL and AML. +other 30878131 hsa-let-7b Precursor Cell Lymphoblastic Leukemia-Lymphoma Also, miR-128a, miR-128b, miR-223, let-7b, miR-155 and miR-24 can be used as diagnostic discriminatory biomarkers between ALL and AML. +other 30878131 hsa-mir-128a Precursor Cell Lymphoblastic Leukemia-Lymphoma Also, miR-128a, miR-128b, miR-223, let-7b, miR-155 and miR-24 can be used as diagnostic discriminatory biomarkers between ALL and AML. +other 30878131 hsa-mir-223 Precursor Cell Lymphoblastic Leukemia-Lymphoma Also, miR-128a, miR-128b, miR-223, let-7b, miR-155 and miR-24 can be used as diagnostic discriminatory biomarkers between ALL and AML. +other 30878131 hsa-mir-155 Precursor Cell Lymphoblastic Leukemia-Lymphoma Also, miR-128a, miR-128b, miR-223, let-7b, miR-155 and miR-24 can be used as diagnostic discriminatory biomarkers between ALL and AML. +other 30878131 hsa-mir-24 Precursor Cell Lymphoblastic Leukemia-Lymphoma Also, miR-128a, miR-128b, miR-223, let-7b, miR-155 and miR-24 can be used as diagnostic discriminatory biomarkers between ALL and AML. +other 30877624 hsa-mir-501 Carcinoma, Hepatocellular The newly identified miR-501/JDP2 axis provides novel insight into the pathogenesis of hepatocellular carcinoma. +transcription factor target 30877521 hsa-mir-34a Epilepsy These results suggest that inhibition of miRNA-34a could suppress epileptiform discharges through regulating Notch signaling and apoptosis in the rat hippocampal neuronal model of SREDs. +genetics_knock down_promote 30877185 hsa-mir-500 Prostatic Neoplasms Increased cell cycle arrest at the G1 stage and decreased protein expression of cyclinD1 and CDK2 was observed in response to miR-500 knockdown in PC-3 and LnCap cells, in combination with LRP1B overexpression. +genetics_knock down_promote 30876979 hsa-mir-216a Stomach Neoplasms Mechanistic investigations revealed that miR-216a-3p was the most remarkably upregulated miRNA in response to BRD4 knockdown and Wnt/beta-catenin signaling was necessary for BRD4-mediated promotion on the stemness of gastric cancer cells. +transcription factor target 30876976 hsa-mir-135a Ischemic Stroke The inhibitor of miR-135a can attenuate si-visfatin suppressed expression of IL-17 and proliferation of AML cells. Collectively, our data suggested that visfatin can increase the malignancy of AML cells via regulation of miR-135a/IL-17/PI3K/Akt signals. +transcription factor target 30876976 hsa-mir-135a Leukemia, Myeloid The inhibitor of miR-135a can attenuate si-visfatin suppressed expression of IL-17 and proliferation of AML cells. Collectively, our data suggested that visfatin can increase the malignancy of AML cells via regulation of miR-135a/IL-17/PI3K/Akt signals. +transcription factor target 30876970 hsa-mir-138 Triple Negative Breast Neoplasms Moreover, miR-138 repression is involved in Sirt1 re-activation and migratory and invasive inhibition of TNBC by C3G. +lncRNA target 30876939 hsa-mir-424 Carcinoma, Hepatocellular 5p inhibited cell proliferation and invasion in vitro and suppressed HCC tumor growth in vivo. +lncRNA target 30876691 hsa-mir-345 Cholangiocarcinoma 5p/COL6A3 axis, which might lead to a better understanding of CCA tumorigenesis and progression and provide potential therapeutic targets for CCA. +lncRNA target 30876481 hsa-mir-486 Diabetic Nephropathies Eventually, we found that miR-486 was the key factors in ADSCs and in the process of ADSCs-Exo-mediated improvement of DN symptom in vivo and in vitro. CONCLUSIONS: In conclusion, we illustrated that ADSCs-Exo vividly ameliorated DN symptom by enhancing the expression of miR-486 which led to the inhibition of Smad1/mTOR signaling pathway in podocyte. +lncRNA target 30876463 hsa-mir-145 Stomach Neoplasms The up-regulation of miR-145 was partly contributed to the inhibitory effect of lidocaine on gastric cancer cell line MKN45. +other 30875963 hsa-mir-451 Glioblastoma "We therefore postulate that AMPK/miR-451 negative reciprocal feedback loop allows GBM cells/GSCs to adapt to tumor ""ecosystem"" by metabolic and behavioral flexibility, and that disruption of such a loop reduces invasiveness and diminishes therapy resistance." +other 30875960 hsa-mir-451a Chemical and Drug Induced Liver Injury However, the functions of miR-451a in hepatotoxicity induced by MC-LR remained unclear. These results showed that miR-451a may protect from MC-LR-induced DNA damage by down-regulating the expression of p-AKT1, which provides new clues for the diagnosis and therapy policies for liver damage induced by MC-LR. +other 30875931 hsa-mir-381 Chronic Periodontitis Salivary hsa-miR3p was correlated with periodontitis condition in chronic periodontitis patients. +other 30875280 hsa-mir-371a Testicular Germ Cell Tumor Teratoma did not express miR-371a-3p. +transcription factor target 30874971 hsa-mir-211 Visceral Pain Therefore, DEX exhibited an analgesic effect on CIVP in rats through a miRmediated MEK/ERK/CREB pathway, suppressing visceral hypersensitivity. +lncRNA target 30874550 hsa-mir-135b Lymphoma, Large B-Cell, Diffuse Our results indicated that SMAD5-AS1 inhibits DLBCL proliferation by sponging miR-135b-5p to up-regulate APC expression and inactivate classic Wnt/beta-catenin pathway, suggesting that SMAD5-AS1 may act as a potential biomarker and therapeutic target for DLBCL. +genetics_knock down_suppress 30874288 hsa-mir-4288 Prostatic Neoplasms Our data suggests that (i) miR-4288 is widely downregulated in primary prostate tumors and cell lines; (ii) miR-4288 expression is lost in metastatic castration-resistant PCa; (ii) miR-4288 downregulation is race-related PCa alteration that is prevalent in Caucasian patients and not in African Americans; (iii) in Caucasians, miR-4288 was found to be associated with increasing tumor grade and high serum prostate-specific antigen, suggesting that miR-4288 downregulation/loss may be associated with tumor progression specifically in Caucasians; (iv) miR-4288 possess significant potential as a molecular biomarker to predict aggressiveness/metastasis; and (v) miR-4288 is anti-proliferative, is anti-invasive and inhibits epithelial-to-mesenchymal transition; and (vi) miR-4288 directly represses expression of metastasis/invasion-associated genes MMP16 and ROCK1. +other 30873956 hsa-mir-34 Vascular Diseases The aim of this study was to investigate the mechanisms underlying how miR-34 participates in vascular disorders. This finding provides an update on the understanding of the clinical value of miR-34, which might assist to uncover novel and effective therapeutic strategies for the treatment of vascular diseases. +other 30873956 hsa-mir-34a Vascular Diseases The aim of this study was to investigate the mechanisms underlying how miR-34 participates in vascular disorders. This finding provides an update on the understanding of the clinical value of miR-34, which might assist to uncover novel and effective therapeutic strategies for the treatment of vascular diseases. +other 30873941 hsa-mir-20a Sjogren's Syndrome OBJECTIVES: To investigate the differential expression of miR92 cluster, which encodes 6 microRNAs (miR-NAs) including miR-17, miR-18a, miR-19a, miR-19b, miR-20a and miR-92a, among varying histological stages of labial minor salivary gland (MSG) tis- sues in patients with primary Sjogren's syndrome (pSS). +other 30873941 hsa-mir-19a Sjogren's Syndrome OBJECTIVES: To investigate the differential expression of miR92 cluster, which encodes 6 microRNAs (miR-NAs) including miR-17, miR-18a, miR-19a, miR-19b, miR-20a and miR-92a, among varying histological stages of labial minor salivary gland (MSG) tis- sues in patients with primary Sjogren's syndrome (pSS). +other 30873941 hsa-mir-19b Sjogren's Syndrome OBJECTIVES: To investigate the differential expression of miR92 cluster, which encodes 6 microRNAs (miR-NAs) including miR-17, miR-18a, miR-19a, miR-19b, miR-20a and miR-92a, among varying histological stages of labial minor salivary gland (MSG) tis- sues in patients with primary Sjogren's syndrome (pSS). +other 30873941 hsa-mir-17 Sjogren's Syndrome OBJECTIVES: To investigate the differential expression of miR92 cluster, which encodes 6 microRNAs (miR-NAs) including miR-17, miR-18a, miR-19a, miR-19b, miR-20a and miR-92a, among varying histological stages of labial minor salivary gland (MSG) tis- sues in patients with primary Sjogren's syndrome (pSS). +other 30873941 hsa-mir-18a Sjogren's Syndrome The association of increased expression levels of miR-18a and reduced expression levels of miR-92a with advanced clinical stages of pSS could significantly reduce the substantial subjectivity of scoring inflammatory infiltrates and may aid in the diagnosis of pSS. +other 30873941 hsa-mir-92a Sjogren's Syndrome The association of increased expression levels of miR-18a and reduced expression levels of miR-92a with advanced clinical stages of pSS could significantly reduce the substantial subjectivity of scoring inflammatory infiltrates and may aid in the diagnosis of pSS. +lncRNA target 30873868 hsa-mir-520f Carcinoma, Non-Small-Cell Lung In addition, we revealed that circ_0043278 sponged miR-520f, which was demonstrated to target ROCK1, CDKN1B, and AKT3 in NSCLC cells. +genetics_knock down_promote 30873717 hsa-mir-944 Colorectal Neoplasms GATA binding protein 6 (GATA6) knockdown can reverse the CRC cells functions induced by miR-944 inhibitor. +lncRNA target 30873673 hsa-mir-451 Breast Neoplasms It has been demonstrated that the PI3K pathway is inappropriately activated in BRCA1-deficient breast cancers which can be downregulated by microRNA 451 (miR-451). To this end, by encapsulating the miR-451 mimic and PARP1 inhibitor in the same cationic liposome, we examined the potential of enhancing the response of PARP1 inhibition on BRCA1-deficient breast cancer by regulating the PI3K pathway. +transcription factor target 30873664 hsa-mir-4458 Triple Negative Breast Neoplasms Furthermore, miR-4458 suppressed cell proliferation and promote cell apoptosis through regulating SOCS1 in TNBC. +genetics_overexpression_suppress 30873211 hsa-mir-106a Squamous Cell Carcinoma of Head and Neck Overexpression of LIMK1 in OSCC cells partially reversed the inhibitory effects of the miR-106a mimic. +circulation_biomarker_diagnosis_ns 30872798 hsa-mir-126 Renal Insufficiency, Chronic In conclusion, CKD is associated with a decrease in circulating miR-223 and miR-126 levels. +other 30872612 hsa-mir-126 Scleroderma, Systemic We conclude that EGFL7 and its specific microRNA miR-126 may be involved in the pathogenesis of SSc vasculopathy and fibrosis. +genetics_GWAS 30872583 hsa-mir-204 Prostatic Neoplasms Mechanically, CUL4B positively regulates SOX4, a key regulator in PCa, through epigenetic silencing of miR-204. +genetics_GWAS 30872409 hsa-mir-499 Uterine Cervical Neoplasms Genetic variants in microRNAs (miRNAs/miRs) play an important role in the susceptibility of various types of cancers.Objective: To evaluate the association of Single Nucleotide Polymorphisms (SNPs) in miR-146a (rs2910164), miR-196a2 (rs11614913), and miR-499 (rs3746444), with cervical cancer susceptibility in Indian population.Methods: Three hundred samples were genotyped by Polymerase chain reaction (PCR)-Restriction fragment length polymorphism (RFLP). +lncRNA target 30872407 hsa-mir-26a Osteoarthritis In response to miR-26a mimics, protein levels of P-IkappaBalpha and P-P65 were reduced; meanwhile, synovial tissue hyperplasia, inflammation and cartilage injury of femoral condyle were ameliorated, with decreased inflammation and cartilage injury scores, and apoptosis of synoviocytes and chondrocytes.Conclusion: MiR-26a suppressed the activation of the NF-kappaB signaling pathway, by which mechanism the synovial inflammation and cartilage injury in OA rats were alleviated. +lncRNA target 30872407 hsa-mir-26a Cartilage Diseases In response to miR-26a mimics, protein levels of P-IkappaBalpha and P-P65 were reduced; meanwhile, synovial tissue hyperplasia, inflammation and cartilage injury of femoral condyle were ameliorated, with decreased inflammation and cartilage injury scores, and apoptosis of synoviocytes and chondrocytes.Conclusion: MiR-26a suppressed the activation of the NF-kappaB signaling pathway, by which mechanism the synovial inflammation and cartilage injury in OA rats were alleviated. +lncRNA target 30872332 hsa-mir-148a Turcot syndrome A comprehensive miRNA screening using The Cancer Genome Atlas (TCGA) dataset (n = 260) combined with eight different miRNA target prediction programs resulted in the identification of a tumor suppressive miRNA, miR-148a-3p, as a potential negative regulator of PD-L1 expression, particularly in dMMR/MSI-H colorectal cancer. +lncRNA target 30872181 hsa-mir-451 Diabetes Mellitus The present study aims to evaluate the effect of miR-451 on cardiac remodeling in diabetic cardiomyopathy. SIGNIFICANCE: miR-451 participates in the pathology of diabetic cardiomyopathy via AMPKa1-regulated EndMT in endothelial cells. +lncRNA target 30872181 hsa-mir-451 Cardiomyopathies The present study aims to evaluate the effect of miR-451 on cardiac remodeling in diabetic cardiomyopathy. SIGNIFICANCE: miR-451 participates in the pathology of diabetic cardiomyopathy via AMPKa1-regulated EndMT in endothelial cells. +lncRNA target 30872089 hsa-mir-34a Acquired Immunodeficiency Syndrome Reciprocally, inhibition of miRNA-34a blocked HIV-1 Tat-mediated microglial activation. +other 30871575 hsa-mir-338 Complex Regional Pain Syndromes CONCLUSIONS: We propose that lower pretreatment levels of miR5p in poor responders are linked to IL-6 levels and inflammation in CRPS. +virus_miRNA 30871221 mdv1-mir-M4 Lymphoma mdv1-miR-M4 is critical for the induction of MDV-induced lymphomas +other 30871013 hsa-mir-199b Colorectal Neoplasms SET was analyzed by immuno-staining in 231 early-stage CRC patients, and miR-199b expression was quantified by real-time PCR in a set of CRC patients. +other 30870990 hsa-mir-155 Niemann-Pick disease type C1 Here, we propose that miR-155 may be a novel indicator of spleen and liver pathology in NPC1. +circulation_biomarker_diagnosis_up 30870834 hsa-mir-218 Prostatic Neoplasms 5p might represent a novel serum biomarker for bone metastasis of PCa. +genetics_knock down_promote 30870812 hsa-mir-21 Thyroid Cancer, Papillary 5p was significantly upregulated in exosomes from papillary thyroid cancer BCPAP cells under hypoxic conditions, while the exosomes isolated from hypoxic BCPAP cells with knockdown of miR +transcription factor target 30870679 hsa-mir-375 Atherosclerosis The results suggest TNA could activate KLF4 and enhance autophagy as well as M2 polarization of macrophages by inhibiting miR-375 to Attenuate Atherosclerosis. +other 30870065 hsa-mir-140 Cleft Lip Gene Set Enrichment Analysis of CL/P-associated DMRs showed an over-representation of genes involved in palate development such as WNT9B, MIR140 and LHX8. +other 30868974 hsa-mir-1301 Carcinoma, Hepatocellular Over-expression of miR-1301 induced by deletion of the KLF6 super enhancer also regulated the expression of p21 and p53 in human hepatoma cells. functional modeling of findings using siRNA specific to miR-1301 showed that expression level changes had direct biological effects on cellular proliferation in Human hepatoma cells. +other 30868951 hsa-mir-125b Adenocarcinoma of Lung Our result suggests that hsa-mir125b-5p can be a prognostic and diagnostic biomarker for LAC. +genetics_overexpression_suppress 30868897 hsa-mir-377 Glioma Overexpression of E2F1 blocked the proliferation repression caused by miR +genetics_overexpression_suppress 30868897 hsa-mir-342 Glioma Overexpression of E2F1 blocked the proliferation repression caused by miR +other 30868896 hsa-mir-1275 Adenocarcinoma of Lung IGF1R may be used as the prognosis indicators in lung adenocarcinoma. +other 30868896 hsa-mir-205 Adenocarcinoma of Lung IGF1R may be used as the prognosis indicators in lung adenocarcinoma. +epigenetics 30868893 hsa-mir-125b-1 Stomach Neoplasms we performed nested methylation-specific polymerase chain reaction (MS-PCR) to evaluate methylation pattern of miR-125b1 promoter and quantitative real-time polymerase chain reaction (qRT-PCR) to determine the RNA expression changes in GC and normal tissues. In conclusion, this is a first report of miR-125b1 promoter methylation in GC. +genetics_overexpression_promote 30868892 hsa-mir-374b Glioblastoma We found that overexpression of miR-374b, which was identified in glioma tissues and cell lines, U251, LN-299 and GOS-3, promoting cell migration and enhancing cell viability but inhibiting cell apoptosis were suggested in this research. +genetics_overexpression_promote 30868891 hsa-mir-423 Thyroid Cancer, Papillary Functional experiments demonstrated that overexpression of miRNA423-5p mimics in exosomes increased PTC cell migration and invasion, while the silencing of miRNA423-5p in TPC-1 cell exosomes inhibited PTC cell migration and invasion in vitro. +genetics_GWAS 30868890 hsa-mir-101 Squamous Cell Carcinoma of Head and Neck In conclusion, our findings suggested that miR-101 inhibited autophagy and proliferation and promoted apoptosis via targeting EZH2 in LSCC, providing a deep insight into the pathogenesis of LSCC and hinting the pivotal roles of epigenetic modifications especially histone methylation in the development of LSCC. +other 30868868 hsa-mir-374a Pancreatitis Two miRNAs, hsa-miR5p and hsa-miR-374a-5p, had significantly down-regulated expression in pancreatitis. +circulation_biomarker_diagnosis_up 30868866 hsa-mir-98 Asthma 5p and IL-13 were determined in the serum of bronchial asthma children. +other 30868853 hsa-mir-122 Oligospermia 5p in the sperm and exfoliated cells of patients with oligospermia semen was 0.0880 /- 0.02581 and 0.5110 /- 0.1087, respectively, which were lower than those in the normal sperm (0.7840 /- 0.2318 and 7.000 /- 2.136), and the differences were significant. +circulation_biomarker_diagnosis_up 30868840 hsa-mir-493 Prostatic Neoplasms PCa cells were transfected with miR-493 mimics, inhibitor, negative control (NC), PH domain leucine-rich-repeats protein phosphatase 2 (PHLPP2), and Akt expressing plasmids and Akt inhibitor MK-2206. +other 30868748 hsa-mir-613 Carcinoma, Non-Small-Cell Lung RESULTS: The interaction network among miRNAs, including hsa-mir3p, hsa-mir-4295, hsa-mir-4288, and hsa-mir-613, promotes lung cancer development by affecting the ERBB pathway. +other 30868748 hsa-mir-185 Carcinoma, Non-Small-Cell Lung RESULTS: The interaction network among miRNAs, including hsa-mir3p, hsa-mir-4295, hsa-mir-4288, and hsa-mir-613, promotes lung cancer development by affecting the ERBB pathway. +other 30868748 hsa-mir-4295 Carcinoma, Non-Small-Cell Lung RESULTS: The interaction network among miRNAs, including hsa-mir3p, hsa-mir-4295, hsa-mir-4288, and hsa-mir-613, promotes lung cancer development by affecting the ERBB pathway. +other 30868748 hsa-mir-4288 Carcinoma, Non-Small-Cell Lung RESULTS: The interaction network among miRNAs, including hsa-mir3p, hsa-mir-4295, hsa-mir-4288, and hsa-mir-613, promotes lung cancer development by affecting the ERBB pathway. +genetics_overexpression_promote 30868061 hsa-mir-25 Neuroblastoma Transfection of miR-25 inhibitor or a Gsk3beta overexpression plasmid attenuated the effects of SLC34A2 overexpression on the stemness of neuroblastoma cells. Our results demonstrate that miR-25/Gsk3beta-mediated activation of Wnt signaling is responsible for SLC34A2-induced enhancement of neuroblastoma cell stemness. +epigenetics 30867812 hsa-mir-493 Colorectal Neoplasms In addition, the expression of DKK2 is switched on via the demethylation of miR +other 30867795 hsa-mir-762 Urinary Bladder Neoplasms In conclusion, the circLPAR1 may function as a potential novel and stable biomarker for the prognosis of MIBC and may be associated with the invasion and metastasis by miR-762. +circulation_biomarker_diagnosis_ns 30867786 hsa-mir-21 Central Nervous System Neoplasms Therefore, miRNA-21 in the plasma may be used as a novel diagnostic biomarker to distinguish patients with PCNSL from those with glioblastoma, whereas miRNA-21 in the CSF may have potential as a predictor of chemotherapeutic effect in PCNSL. +genetics_overexpression_promote 30867780 hsa-mir-497 Carcinoma, Non-Small-Cell Lung Overexpression of FGF2 impaired the inhibitory effect of miR +lncRNA target 30867779 hsa-mir-26b Uterine Cervical Neoplasms In conclusion, miR-26b suppresses cell migration and invasion of cervical cancer through directly targeting JAG1. +lncRNA target 30867777 hsa-mir-124 gastric adenocarcinoma miR-124 can inhibit the proliferation and invasion of gastric adenocarcinoma cells. +other 30867774 hsa-mir-1202 Uterine Cervical Neoplasms The expression levels of miR-1202 and miR-195 in the cervical cancer patients are different in different stages. +other 30867774 hsa-mir-195 Uterine Cervical Neoplasms The expression levels of miR-1202 and miR-195 in the cervical cancer patients are different in different stages. +genetics_GWAS 30867770 hsa-mir-22 Thyroid Cancer, Papillary Furthermore, miR-22 serum levels were increased in patients with PTC and the B-Raf proto-oncogene, serine/threonine kinase V600E mutation. +lncRNA target 30867768 hsa-mir-1 Uterine Cervical Neoplasms In vitro, miRNA-1 inhibited the proliferation and migration of cervical cancer cell lines by downregulating c-Met mRNA. +genetics_overexpression_suppress 30867757 hsa-mir-1291 Prostatic Neoplasms miR-1291 mimics and inhibitors were applied to overexpress or inhibit the level of miR-1291 in PCa cells. +circulation_biomarker_diagnosis_up 30867756 hsa-mir-197 Carcinoma, Non-Small-Cell Lung The AUC of serum miR-197 diagnosis of NSCLC was 0.864 (95% CI: 0.804-0.924), with a diagnostic sensitivity of 73.68% and a specificity of 85.00%; the AUC of serum miR-145 diagnosis of NSCLC was 0.879 (95% CI: 0.824-0.934), with a diagnostic sensitivity of 84.21% and a specificity of 71.67%; the AUC of the diagnosis of the combination of serum miR-197 and miR-145 for NSCLC was 0.952 (95% CI: 0.919-0.984), with a diagnostic sensitivity of 92.10% and a specificity of 78.33%. +circulation_biomarker_diagnosis_up 30867756 hsa-mir-145 Carcinoma, Non-Small-Cell Lung The AUC of serum miR-197 diagnosis of NSCLC was 0.864 (95% CI: 0.804-0.924), with a diagnostic sensitivity of 73.68% and a specificity of 85.00%; the AUC of serum miR-145 diagnosis of NSCLC was 0.879 (95% CI: 0.824-0.934), with a diagnostic sensitivity of 84.21% and a specificity of 71.67%; the AUC of the diagnosis of the combination of serum miR-197 and miR-145 for NSCLC was 0.952 (95% CI: 0.919-0.984), with a diagnostic sensitivity of 92.10% and a specificity of 78.33%. +genetics_overexpression_promote 30867755 hsa-mir-7 Colorectal Neoplasms Notably, KLF4 overexpression rescued the suppressive effects of miR +lncRNA target 30867752 hsa-mir-127 Stomach Neoplasms In addition, Wnt7a siRNA significantly inhibited GC cell migration and invasion and Wnt7a was verified as a specific target of miR-127 in GC cells. +genetics_overexpression_suppress 30867751 hsa-mir-218 Carcinoma, Renal Cell Additionally, the downregulation of CIP2A or overexpression of miR-218 in ccRCC cells was revealed to inhibit cell proliferation and migration. +other 30867721 hsa-mir-212 Pancreatic Carcinoma Collectively, these results demonstrated that HIF-1alpha positively regulated miR-212 expression and resulted in PDAC progression. +lncRNA target 30867715 hsa-mir-34a Fibrosis, Renal MicroRNA-34a secreted by damaged renal interstitial fibroblasts can promote renal tubular epithelial cell apoptosis and participate in renal interstitial fibrosis by inhibiting Bcl-2. +transcription factor target 30867712 hsa-mir-205 Cicatrix, Hypertrophic 5p suppressed HSF cell proliferation and induced cell apoptosis. +genetics_knock down_promote 30867707 hsa-mir-150 Breast Neoplasms 5p knockdown inhibited breast cancer cell viability, invasion and migration. +other 30867694 hsa-mir-374a Glioma In conclusion, the present study indicated that miR-374a may be used as a promising prognostic biomarker for the screening of high-risk populations and for the assessment of the prognosis of patients with glioma. +genetics_overexpression_promote 30867688 hsa-mir-186 Carcinoma, Squamous Cell, Cutaneous Overexpression of miR-186 significantly promoted CSCC cell proliferation while inhibiting cell apoptosis. +genetics_overexpression_promote 30867685 hsa-mir-375 Esophageal Squamous Cell Carcinoma miR-375 overexpression significantly decreased ESCC cell proliferation and colony formation. +circulation_biomarker_diagnosis_ns 30867638 hsa-mir-1246 Liver Neoplasms The purpose of this study was to evaluate the potential value of a panel of HCC-related circulating miRNAs (miR-142, miR-182, miR-200a, mir-210, miR-211, miR-302b, miR-324, miR-338, miR-340 and miR-1246) as noninvasive biomarkers for discriminating primary HCC from metastatic tumors in the liver. CONCLUSIONS: Serum miR-210 and miR-1246 have some diagnostic value for discriminating patients with metastatic tumors to patients with primary HCC. +circulation_biomarker_diagnosis_ns 30867638 hsa-mir-211 Carcinoma, Hepatocellular The purpose of this study was to evaluate the potential value of a panel of HCC-related circulating miRNAs (miR-142, miR-182, miR-200a, mir-210, miR-211, miR-302b, miR-324, miR-338, miR-340 and miR-1246) as noninvasive biomarkers for discriminating primary HCC from metastatic tumors in the liver. +circulation_biomarker_diagnosis_ns 30867638 hsa-mir-210 Carcinoma, Hepatocellular The purpose of this study was to evaluate the potential value of a panel of HCC-related circulating miRNAs (miR-142, miR-182, miR-200a, mir-210, miR-211, miR-302b, miR-324, miR-338, miR-340 and miR-1246) as noninvasive biomarkers for discriminating primary HCC from metastatic tumors in the liver. +circulation_biomarker_diagnosis_ns 30867638 hsa-mir-211 Liver Neoplasms The purpose of this study was to evaluate the potential value of a panel of HCC-related circulating miRNAs (miR-142, miR-182, miR-200a, mir-210, miR-211, miR-302b, miR-324, miR-338, miR-340 and miR-1246) as noninvasive biomarkers for discriminating primary HCC from metastatic tumors in the liver. +circulation_biomarker_diagnosis_ns 30867638 hsa-mir-340 Carcinoma, Hepatocellular The purpose of this study was to evaluate the potential value of a panel of HCC-related circulating miRNAs (miR-142, miR-182, miR-200a, mir-210, miR-211, miR-302b, miR-324, miR-338, miR-340 and miR-1246) as noninvasive biomarkers for discriminating primary HCC from metastatic tumors in the liver. +circulation_biomarker_diagnosis_ns 30867638 hsa-mir-340 Liver Neoplasms The purpose of this study was to evaluate the potential value of a panel of HCC-related circulating miRNAs (miR-142, miR-182, miR-200a, mir-210, miR-211, miR-302b, miR-324, miR-338, miR-340 and miR-1246) as noninvasive biomarkers for discriminating primary HCC from metastatic tumors in the liver. +circulation_biomarker_diagnosis_ns 30867638 hsa-mir-1246 Carcinoma, Hepatocellular The purpose of this study was to evaluate the potential value of a panel of HCC-related circulating miRNAs (miR-142, miR-182, miR-200a, mir-210, miR-211, miR-302b, miR-324, miR-338, miR-340 and miR-1246) as noninvasive biomarkers for discriminating primary HCC from metastatic tumors in the liver. CONCLUSIONS: Serum miR-210 and miR-1246 have some diagnostic value for discriminating patients with metastatic tumors to patients with primary HCC. +circulation_biomarker_diagnosis_ns 30867638 hsa-mir-24 Carcinoma, Hepatocellular The purpose of this study was to evaluate the potential value of a panel of HCC-related circulating miRNAs (miR-142, miR-182, miR-200a, mir-210, miR-211, miR-302b, miR-324, miR-338, miR-340 and miR-1246) as noninvasive biomarkers for discriminating primary HCC from metastatic tumors in the liver. +circulation_biomarker_diagnosis_ns 30867638 hsa-mir-24 Liver Neoplasms The purpose of this study was to evaluate the potential value of a panel of HCC-related circulating miRNAs (miR-142, miR-182, miR-200a, mir-210, miR-211, miR-302b, miR-324, miR-338, miR-340 and miR-1246) as noninvasive biomarkers for discriminating primary HCC from metastatic tumors in the liver. +circulation_biomarker_diagnosis_ns 30867638 hsa-mir-210 Liver Neoplasms The purpose of this study was to evaluate the potential value of a panel of HCC-related circulating miRNAs (miR-142, miR-182, miR-200a, mir-210, miR-211, miR-302b, miR-324, miR-338, miR-340 and miR-1246) as noninvasive biomarkers for discriminating primary HCC from metastatic tumors in the liver. +circulation_biomarker_diagnosis_ns 30867638 hsa-mir-142 Liver Neoplasms The purpose of this study was to evaluate the potential value of a panel of HCC-related circulating miRNAs (miR-142, miR-182, miR-200a, mir-210, miR-211, miR-302b, miR-324, miR-338, miR-340 and miR-1246) as noninvasive biomarkers for discriminating primary HCC from metastatic tumors in the liver. +circulation_biomarker_diagnosis_ns 30867638 hsa-mir-142 Carcinoma, Hepatocellular The purpose of this study was to evaluate the potential value of a panel of HCC-related circulating miRNAs (miR-142, miR-182, miR-200a, mir-210, miR-211, miR-302b, miR-324, miR-338, miR-340 and miR-1246) as noninvasive biomarkers for discriminating primary HCC from metastatic tumors in the liver. +circulation_biomarker_diagnosis_ns 30867638 hsa-mir-182 Carcinoma, Hepatocellular The purpose of this study was to evaluate the potential value of a panel of HCC-related circulating miRNAs (miR-142, miR-182, miR-200a, mir-210, miR-211, miR-302b, miR-324, miR-338, miR-340 and miR-1246) as noninvasive biomarkers for discriminating primary HCC from metastatic tumors in the liver. +circulation_biomarker_diagnosis_ns 30867638 hsa-mir-338 Liver Neoplasms The purpose of this study was to evaluate the potential value of a panel of HCC-related circulating miRNAs (miR-142, miR-182, miR-200a, mir-210, miR-211, miR-302b, miR-324, miR-338, miR-340 and miR-1246) as noninvasive biomarkers for discriminating primary HCC from metastatic tumors in the liver. +circulation_biomarker_diagnosis_ns 30867638 hsa-mir-182 Liver Neoplasms The purpose of this study was to evaluate the potential value of a panel of HCC-related circulating miRNAs (miR-142, miR-182, miR-200a, mir-210, miR-211, miR-302b, miR-324, miR-338, miR-340 and miR-1246) as noninvasive biomarkers for discriminating primary HCC from metastatic tumors in the liver. +circulation_biomarker_diagnosis_ns 30867638 hsa-mir-338 Carcinoma, Hepatocellular The purpose of this study was to evaluate the potential value of a panel of HCC-related circulating miRNAs (miR-142, miR-182, miR-200a, mir-210, miR-211, miR-302b, miR-324, miR-338, miR-340 and miR-1246) as noninvasive biomarkers for discriminating primary HCC from metastatic tumors in the liver. +lncRNA target 30867288 hsa-mir-34a Heart Failure In this pathway, initial cardiac defects diminish RBFox2 expression, which induces transcriptional repression of miR-34a, and elevated miR-34a targets Jph2 to impair EC coupling, which further manifests heart dysfunction, leading to progressive heart failure. +other 30867286 hsa-mir-122 Pneumonia Our findings reveal a causative role of hepatic miR-122 in liver injury-induced pulmonary dysfunction. +lncRNA target 30866999 hsa-mir-137 Pancreatic Carcinoma CONCLUSION: Our results suggest that miR-137 reduces stemness features of pancreatic cancer cells by Targeting KLF12-associated Wnt/beta-catenin pathways and may identify new diagnostic and therapeutic targets in pancreatic cancer. +exosome 30866952 hsa-mir-5100 Lung Neoplasms CONCLUSIONS Exosome-mediated transfer of miR-193a-3p, miR3p and miR-5100, could promote invasion of lung cancer cells by activating STAT3 signalling-induced EMT. +exosome 30866952 hsa-mir-210 Lung Neoplasms CONCLUSIONS Exosome-mediated transfer of miR-193a-3p, miR3p and miR-5100, could promote invasion of lung cancer cells by activating STAT3 signalling-induced EMT. +exosome 30866952 hsa-mir-193a Lung Neoplasms CONCLUSIONS Exosome-mediated transfer of miR-193a-3p, miR3p and miR-5100, could promote invasion of lung cancer cells by activating STAT3 signalling-induced EMT. +lncRNA target 30866526 hsa-mir-204 Carcinoma, Pancreatic Ductal Comprehensive gene expression analyses and in silico database searches revealed 25 putative targets regulated by miR +transcription factor target 30865617 hsa-mir-195 Glomerulonephritis, Membranous Thirteen genes were shared between the DEGs in PMBCs and the target genes of DEMs in urine sediments, but only hsa-miR +circulation_biomarker_diagnosis_ns 30865617 hsa-mir-28 Glomerulonephritis, Membranous CONCLUSIONS Both peripheral blood and urinary miR +circulation_biomarker_diagnosis_ns 30865617 hsa-mir-192 Glomerulonephritis, Membranous CONCLUSIONS Both peripheral blood and urinary miR +lncRNA target 30865310 hsa-mir-148a Carcinoma, Hepatocellular Furthermore, miR-148a, whose down-regulation was associated with an increase of lnc-UCID in HCC, could bind lnc-UCID and inhibit its expression. Conclusion: Up-regulation of lnc-UCID, which may result from amplification of its gene locus and down-regulation of miR-148a, can promote HCC growth by preventing the interaction of DHX9 with CDK6 and subsequently enhancing CDK6 expression. +other 30865275 hsa-mir-423 Polycystic Ovary Syndrome We found that miR-423 expression was downregulated (P = 0.038), and the levels of miR-33b (P = 0.032) and miR-142 (P = 0.021) were upregulated in GCs from patients with PCOS, compared to controls. +other 30865275 hsa-mir-142 Polycystic Ovary Syndrome We found that miR-423 expression was downregulated (P = 0.038), and the levels of miR-33b (P = 0.032) and miR-142 (P = 0.021) were upregulated in GCs from patients with PCOS, compared to controls. +lncRNA target 30864841 hsa-mir-155 Acute Kidney Injury Collectively, these data provide strong evidence that LPS induces tubular cell apoptosis via upregulating PUMA and miR-155, whereas vitamin D/VDR signaling protects against AKI by blocking NF-kappaB-mediated PUMA and miR-155 upregulation. +circulation_biomarker_diagnosis_up 30864744 hsa-mir-216a Breast Neoplasms The results demonstrated that serum microRNA-216a was significantly decreased in patients with breast cancer compared with healthy controls. +lncRNA target 30864742 hsa-mir-145 Ovarian Neoplasms Therefore, miR145 was suggested to be a potential miRNAbased therapeutic target in ovarian cancer. +genetics_knock down_promote 30864732 hsa-mir-142 Pneumonia, Mycoplasma Microarray analysis and RTqPCR revealed that miR1423p was significantly upregulated in placenta specimens from patients with PE. Taken together, the results of the present study suggest that miR1423p may serve an important role in human placental development by suppressing trophoblast cell invasion and migration through disruption of the TGFbeta1/smad3 signaling pathway, suggesting that knockdown of miR1423p may provide a novel therapy for PE. +genetics_overexpression_promote 30864722 hsa-mir-146a Uterine Cervical Neoplasms In a coculture of cervical cancer and CD4+ T cells, downregulation of miR146a inhibited cell growth and induced apoptosis of cervical cancer cells, while overexpression of miR146a promoted cell growth and reduced apoptosis of cervical cancer cells. +circulation_biomarker_diagnosis_up 30864721 hsa-mir-107 Atherosclerosis It was identified that the expression of circRNA0044073 was upregulated and the expression of miR107 was downregulated in atherosclerotic blood cells. +genetics_overexpression_promote 30864719 hsa-mir-199a Carcinoma, Hepatocellular Additionally, AB209371 silencing combined with hsamiR199a5p overexpression may be an effective means to inhibit the metastasis of HCC and the EMT of HCC cells. +lncRNA target 30864704 hsa-mir-145 Stomach Neoplasms Collectively, the present results suggest that miR145 is a tumor suppressor for gastric cancer and it may be a potential therapeutic target for gastric cancer treatment. +other 30864698 hsa-mir-590 Arthritis, Rheumatoid In brief, reverse transcriptionquantitative polymerase chain reaction was used to analyze miR590 expression in bone tissue samples from rats with OA. Taken together, the present data suggested that miR590 promoted apoptosis in bone cells from rats with OA by regulating the TGFbeta1/PI3K signaling pathway. +genetics_GWAS 30864695 hsa-mir-499a Carcinoma, Non-Small-Cell Lung Single nucleotide polymorphism rs3746444 in miR499a affects susceptibility to nonsmall cell lung carcinoma by regulating the expression of CD200. These findings indicate that the SNP rs3746444 in miR499a could affect the prognosis of NSCLC patients by regulating the expression of CD200. +circulation_biomarker_diagnosis_up 30864684 hsa-mir-505 Adenocarcinoma of Lung The four disordered miRNAs (miR5055p, miR4863p, miR4863p and miR3823p) identified in the plasma EVs were further evaluated at the testing stage (108 patients with LA vs. +transcription factor target 30864677 hsa-mir-103a Ischemia Therefore, miR103a3p can be considered a potential therapeutic target for myocardial ischemia. +transcription factor target 30864677 hsa-mir-103a Myocardial Ischemia Therefore, miR103a3p can be considered a potential therapeutic target for myocardial ischemia. +lncRNA target 30864145 hsa-mir-140 Carcinoma, Hepatocellular Downregulation of circDYNC1H1 disturbed cell proliferation and migration of HCC through miR +other 30864107 hsa-mir-138 Osteosarcoma 5p as a consistent prognostic factor in pediatric and young adult OS, reinforcing its participation in the post-transcriptional regulation of ROCK kinases. +genetics_GWAS 30863967 hsa-mir-196a-2 Prostatic Neoplasms The purpose of this study was to examine the possible association between the hsa-miR-499 (rs3746444) and hsa-miR-196a2 (rs11614913) gene polymorphisms with the risk of PCa. The findings suggested that no correlation between hsa-miR-196a2 gene polymorphism and PCa susceptibility in an Iranian population. +genetics_overexpression_promote 30863186 hsa-mir-491 Colorectal Neoplasms 5p in CRC cells, and overexpression of IGF2 rescued the miR +lncRNA target 30863183 hsa-mir-939 Colorectal Neoplasms Lastly, we revealed that LINC00460 promoted LIMK2-mediated metastasis via miR +lncRNA target 30863152 hsa-mir-193a Prostatic Neoplasms Bioinformatics analysis and luciferase reporter assays demonstrated that circHIPK3 could promote MCL1 expression by interacting with miR-193a-3p in PCa. CONCLUSION: In summary, our study illustrated, for the first time, that circHIPK3-mediated miR-193a-3p-MCL1 signaling promotes PCa development and progression, providing a novel therapeutic target for PCa. +transcription factor target 30863112 hsa-mir-935 Carcinoma, Non-Small-Cell Lung CONCLUSION: The study revealed that IL-27 decreased lung cancer cell proliferation and metastasis via miR-935. +lncRNA target 30863107 hsa-mir-4792 Diabetes Mellitus Kyoto Encyclopedia of Genes and Genomes analysis showed that target genes of miR-4792 were enriched in aminoacyltRNA biosynthesis, AGE-RAGE signaling pathway in diabetic complications, sphingolipid signaling pathway, neuroactive ligand-receptor interaction, glycosaminoglycan degradation, and regulation of lipolysis in adipocytes. +genetics_knock down_promote 30863103 hsa-mir-140 Squamous Cell Carcinoma of Head and Neck Finally, MALAT1 knockdown inhibited tumor growth by upregulating miR +lncRNA target 30862569 hsa-mir-9 Pancreatitis BMSCs secreted miR-9, which targeted the gene encoding receptor interacting protein kinase 1 in PACs induced by TNF-alpha, to inhibit necroptosis and ameliorate SAP. +other 30862410 hsa-mir-140 Diabetes Mellitus 3p/FOXK2 cascade by hyperglycemia thus serves as an important contributor to angiogenic dysfunction in DM. +lncRNA target 30862230 hsa-mir-23a Ovarian Neoplasms In addition, when miR-23a was suppressed, cell viability, migration, invasion, cloning, and renewal abilities of OC stem cells were decreased, while apoptosis ability was enhanced. +circulation_biomarker_diagnosis_up 30862139 hsa-mir-21 Esophageal Neoplasms The expression levels of miR-18a and miR-21 in peripheral blood of patients with esophageal cancer were 12.66+/-11.92 and 9.15+/-8.14, respectively, significantly higher than those in the normal control group (both P<0.001). +circulation_biomarker_diagnosis_up 30862139 hsa-mir-18a Esophageal Neoplasms The expression levels of miR-18a and miR-21 in peripheral blood of patients with esophageal cancer were 12.66+/-11.92 and 9.15+/-8.14, respectively, significantly higher than those in the normal control group (both P<0.001). +lncRNA target 30862136 hsa-mir-133b Esophageal Squamous Cell Carcinoma Conclusion: MiR-133b plays an important role in the proliferation and invasion of ESCC cells by regulating TAGLN2 expression, and it may be a potential therapeutic target for ESCC patients. +other 30862091 hsa-mir-193b Colorectal Neoplasms 5p and miR-193b-5p. +other 30862091 hsa-mir-145 Colorectal Neoplasms 5p and miR-193b-5p. +other 30862091 hsa-mir-24 Colorectal Neoplasms miR-23b-3p and miR3p discriminated between Lynch Syndrome and sporadic CRC. +other 30862091 hsa-mir-1 Colorectal Neoplasms 5p and miR-193b-5p. +other 30862091 hsa-mir-23b Colorectal Neoplasms miR-23b-3p and miR3p discriminated between Lynch Syndrome and sporadic CRC. +other 30862091 hsa-mir-143 Colorectal Neoplasms 5p and miR-193b-5p. +lncRNA target 30861616 hsa-mir-28 Pancreatic Carcinoma Our results implicate that propofol inhibits pancreatic cancer growth and metastasis by enhancing miR-328 which targets ADAM8. +lncRNA target 30861602 hsa-mir-16 Hepatitis C CONCLUSIONS: The interplay between IFN and TGFbeta pathways through IRF3 and SMAD7 in the context of immunity against HCV infection could be under the control of miR16. +other 30861600 hsa-mir-637 Essential Hypertension RESULTS The expression level of hsa_circ_0037909 in EH patients was significantly higher than that in the healthy controls (P = 0.007), and the expression level of hsa-miR-637 in EH patients was significantly lower in than that in the healthy controls (P = 0.039); the same result appears in the HAECs and HUVECs. CONCLUSIONS Our findings suggested that the combination of hsa_circ_0037911 and hsa-miR-637 may be a significant important biomarker for early diagnosis of EH. +transcription factor target 30861353 hsa-mir-483 Colorectal Neoplasms These findings demonstrate that FAM171B is a functional target of miR +genetics_knock down_suppress 30861258 hsa-mir-124a Non-alcoholic Fatty Liver Disease CONCLUSIONS: MicroRNA-124a overexpression contributes to the progression of NAFLD through reduction of ATGL expression, whereas miR-124a knockdown can reverse this trend, suggesting that miR-124a and its downstream target ATGL can be novel therapeutic targets of NAFLD. +genetics_GWAS 30861198 hsa-mir-34b Glaucoma, Open-Angle Therefore, the presence of anti-miR-34b suppressed cell proliferation and promoted cell apoptosis, thus establishing a molecular mechanism underlying the protective effect of rs4938723 polymorphism T > C against the risk of POAG. +genetics_overexpression_promote 30861181 hsa-mir-21 Myocardial Infarction TALNEC2 could negative regulate the miR-21 expression, and overexpression of TALNEC2 aggravated hypoxia injury by downregulation of miR-21. +circulation_biomarker_diagnosis_up 30861177 hsa-mir-25 Stomach Neoplasms The aim of this study was to investigate the microRNA-17 (miR-17), miR-25, and miR-133b in the serum of gastric cancer subjects. +circulation_biomarker_diagnosis_up 30861177 hsa-mir-133b Stomach Neoplasms The aim of this study was to investigate the microRNA-17 (miR-17), miR-25, and miR-133b in the serum of gastric cancer subjects. +circulation_biomarker_diagnosis_up 30861177 hsa-mir-17 Stomach Neoplasms The aim of this study was to investigate the microRNA-17 (miR-17), miR-25, and miR-133b in the serum of gastric cancer subjects. +exosome 30860987 hsa-mir-21 Brain Injuries, Traumatic 5p in neuronal exosomes increased from the acute to the chronic phase of TBI. +lncRNA target 30860979 hsa-mir-185 Glioma LncRNA FOXD2-AS1 modulated HMGA2 and PI3K/Akt downstream signaling through sponging miR +lncRNA target 30860873 hsa-let-7 Muscular Dystrophy, Oculopharyngeal Aging-associated genes and let-7 microRNAs: a contribution to myogenic program dysregulation in oculopharyngeal muscular dystrophy. Aging-associated genes and let-7 microRNAs: a contribution to myogenic program dysregulation in oculopharyngeal muscular dystrophy. +lncRNA target 30860638 hsa-mir-181b Kidney Diseases Inhibition of lncRNA MEG3 protects renal tubular from hypoxia-induced kidney injury in acute renal allografts by regulating miR-181b/TNF- signaling pathway. Our data suggested that MEG3 functions as a competing endogenous RNA for miR-181b to regulate the TNF-alpha expression in hypoxia-induced kidney injury in acute renal allografts. +lncRNA target 30860027 hsa-mir-34a Prostatic Neoplasms As part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Li et al., 2015), that described how we intended to replicate selected experiments from the paper 'The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44' (Liu et al., 2011). We found the microRNA, miR-34a, was expressed at twice the level in CD44(+) prostate cancer cells purified from xenograft tumors (LAPC4 cells) compared to CD44(-) LAPC4 cells, whereas the original study reported miR-34a was underexpressed in CD44(+) LAPC4 cells (Figure 1B; Liu et al., 2011). +lncRNA target 30859853 hsa-mir-526b Uterine Cervical Neoplasms miRNA-526b was found to be able to inhibit the EMT property of CC cells by directly targeting PBX3. +lncRNA target 30859368 hsa-mir-216b Carcinoma, Non-Small-Cell Lung Beclin-1 reversed miR-216b-mediated effect on autophagy and apoptosis of NSCLC cells ((*)P < 0.05,(#)P < 0.05). CONCLUSIONS: PVT1 may function as a competing endogenous RNA for miR-216b to inhibit cisplatin sensitivity of NSCLC through regulating apoptosis and autophagy via miR-216b/Beclin-1 pathway, providing a novel target for improving chemo-therapy efficacy of NSCLC. +other 30859354 hsa-mir-222 Breast Neoplasms To reconstruct the microRNAs-genes regulatory network in breast cancer, we employed the expression data from The Cancer Genome Atlas (TCGA) related to five essential miRNAs including miR-21, miR-22, miR-210, miR-221, and miR-222, and their associated functional genomics data from the GEO database. +other 30859354 hsa-mir-22 Breast Neoplasms To reconstruct the microRNAs-genes regulatory network in breast cancer, we employed the expression data from The Cancer Genome Atlas (TCGA) related to five essential miRNAs including miR-21, miR-22, miR-210, miR-221, and miR-222, and their associated functional genomics data from the GEO database. +other 30859354 hsa-mir-21 Breast Neoplasms To reconstruct the microRNAs-genes regulatory network in breast cancer, we employed the expression data from The Cancer Genome Atlas (TCGA) related to five essential miRNAs including miR-21, miR-22, miR-210, miR-221, and miR-222, and their associated functional genomics data from the GEO database. +other 30859354 hsa-mir-221 Breast Neoplasms To reconstruct the microRNAs-genes regulatory network in breast cancer, we employed the expression data from The Cancer Genome Atlas (TCGA) related to five essential miRNAs including miR-21, miR-22, miR-210, miR-221, and miR-222, and their associated functional genomics data from the GEO database. +other 30859354 hsa-mir-210 Breast Neoplasms To reconstruct the microRNAs-genes regulatory network in breast cancer, we employed the expression data from The Cancer Genome Atlas (TCGA) related to five essential miRNAs including miR-21, miR-22, miR-210, miR-221, and miR-222, and their associated functional genomics data from the GEO database. +circulation_biomarker_diagnosis_up 30859103 hsa-mir-146a Liver Injury Five miRs, miR-122, let7f, miR-21, miR-29a, and miR-146a, were reduced in the blood EVs from the EtOH w/o LI group, vs. no EtOH (p < 0.05). +circulation_biomarker_diagnosis_up 30859103 hsa-mir-21 Liver Injury Five miRs, miR-122, let7f, miR-21, miR-29a, and miR-146a, were reduced in the blood EVs from the EtOH w/o LI group, vs. no EtOH (p < 0.05). +circulation_biomarker_diagnosis_up 30859103 hsa-mir-146a Wounds and Injuries Five miRs, miR-122, let7f, miR-21, miR-29a, and miR-146a, were reduced in the blood EVs from the EtOH w/o LI group, vs. no EtOH (p < 0.05). +circulation_biomarker_diagnosis_up 30859103 hsa-mir-21 Wounds and Injuries Five miRs, miR-122, let7f, miR-21, miR-29a, and miR-146a, were reduced in the blood EVs from the EtOH w/o LI group, vs. no EtOH (p < 0.05). +circulation_biomarker_diagnosis_up 30859103 hsa-mir-29a Wounds and Injuries Five miRs, miR-122, let7f, miR-21, miR-29a, and miR-146a, were reduced in the blood EVs from the EtOH w/o LI group, vs. no EtOH (p < 0.05). +circulation_biomarker_diagnosis_up 30859103 hsa-mir-29a Liver Injury Five miRs, miR-122, let7f, miR-21, miR-29a, and miR-146a, were reduced in the blood EVs from the EtOH w/o LI group, vs. no EtOH (p < 0.05). +genetics_GWAS 30858762 hsa-mir-140 Uterine Cervical Neoplasms 5p/ORC1 axis on the progression of cervical cancer which will shed new light on epigenetic diagnostics and therapeutics in cervical cancer. +transcription factor target 30858759 hsa-mir-182 Urinary Bladder Neoplasms 5p could inhibit human bladder tumor growth by repressing Cofilin 1 expression. +exosome 30858545 hsa-mir-339 Esophageal Squamous Cell Carcinoma Overall, exosome-derived miR +lncRNA target 30858505 hsa-mir-130b Carcinoma, Pancreatic Ductal A total of 103 genes were identified as possible oncogenic targets by miR-130b-5p regulation in PDAC cells based on genome-wide gene expression analysis and in silico database search. +transcription factor target 30858037 hsa-mir-455 Pulmonary Arterial Hypertension 3p-1 could inhibit the proliferation of PASMCs and mitigate PAH in vivo. +transcription factor target 30858031 hsa-mir-372 Mouth Neoplasms Collectively, our present study suggested that MEHP can promote the growth and progression of OSCC via down regulation of miR-27b-5p and miR +other 30857885 hsa-mir-101 Liver Cirrhosis CONCLUSIONS: MiR-101 has antifibrotic effects in experimental liver fibrosis, and downregulating the PI3K/Akt/mTOR signaling pathway may be one of its antifibrotic mechanisms. +lncRNA target 30857769 hsa-mir-142 Anxiety Disorders In addition, the inhibition of microRNA-142 following exposure to single prolonged stress exhibited decreased anxiety-like behaviors and memory deficits, as well as increased expression of Npas4 and BDNF. +other 30856535 hsa-mir-499a Substance Abuse, Intravenous Nonetheless, the expression level and biological function of miR-499a-5p in IVDD are still unclear. +other 30856535 hsa-mir-499a Neurodegenerative Diseases In this study, we found that miR-499a-5p was significantly downregulated in degenerative tissues of the human nucleus pulposus (NP) compared with healthy tissues. +genetics_knock down_promote 30856484 hsa-let-7a Non-AIDS-related Kaposi sarcoma Let-7a overexpression or RBPJ knockdown led to a dose- and time-dependent inhibition of lytic reactivation of KSHV. Collectively, these findings support a model wherein LANA inhibits the lytic replication of KSHV by regulating let-7a/RBPJ signaling. +other 30856428 hsa-mir-21 Breast Neoplasms Moreover, this ECL biosensor was applied to estimate the expression level of miRNA-21 and pharmacodynamics of matrine in human breast cancer cells (MCF-7 cells). +other 30856381 hsa-mir-183 Thrombocytopenia 5p expression levels in CD4(+) cells were abnormal in ITP patients. +genetics_overexpression_promote 30856345 hsa-mir-361 Uterine Cervical Neoplasms 5p and led to overexpression of FOXM1 in CC cells. +genetics_knock down_promote 30856284 hsa-mir-22 Cholangiocarcinoma The effect of MIR22HG overexpression on CCA progression could be partly rescued by activating the Wnt/beta-catenin signaling pathway. +transcription factor target 30855347 hsa-mir-29b Peritoneal Fibrosis CONCLUSIONS: Matrine could inhibit LPS-induced EMT in HPMCs and reverse LPS inhibited expressions of miR-29 b and miR5P in HPMCs, ultimately reduce peritoneal fibrosis. +transcription factor target 30855347 hsa-mir-129 Peritoneal Fibrosis CONCLUSIONS: Matrine could inhibit LPS-induced EMT in HPMCs and reverse LPS inhibited expressions of miR-29 b and miR5P in HPMCs, ultimately reduce peritoneal fibrosis. +circulation_biomarker_diagnosis_up 30854934 hsa-mir-204 Hypertension, Pulmonary The stepwise elevation of circulating miR-204 across the pulmonary vasculature in Group I, but not Group II, PH indicates differences in muscle-specific pathobiology between subtypes. +other 30854930 hsa-mir-145 Colorectal Neoplasms CONCLUSION: miR-143 and miR-145 have promising prognostic value for colorectal cancer. +other 30854930 hsa-mir-143 Colorectal Neoplasms The results showed that there was no significant difference between low expression and high expression of miR-143 in the overall survival of colon cancer patients. +transcription factor target 30854734 hsa-mir-193b Osteoarthritis miR-193b-5p downregulates HDAC7 directly and, as a result, inhibits MMP3 and MMP13 expression, which suggests that miR-193b-5p has a protective role in OA. +genetics_overexpression_promote 30854695 hsa-mir-19a Arthritis, Rheumatoid In addition, SOCS3 overexpression abrogated the effects of miR-19a-3p overexpression on cell proliferation and apoptosis, corroborating that SOCS3 acts as a downstream effector in the miR-19a-3p-mediated function of RAFLS. +exosome 30854665 hsa-mir-23a Liver Neoplasms Conclusion: ER-stressed HCC cells release exosomes to up-regulate PD-L1 expression in macrophages, which subsequently inhibits T-cell function through an exosome miR-23a-PTEN-AKT pathway. +transcription factor target 30854483 hsa-mir-200a Gliosis Inhibition of miR-200a during regeneration causes defects in axonal regrowth and transcriptomic analysis revealed that miR-200a inhibition leads to differential regulation of genes involved with reactive gliosis, the glial scar, extracellular matrix remodeling and axon guidance. This work identifies a unique role for miR-200a in inhibiting reactive gliosis in axolotl glial cells during spinal cord regeneration. +transcription factor target 30854483 hsa-mir-200a Spinal Cord Diseases This work identifies a unique role for miR-200a in inhibiting reactive gliosis in axolotl glial cells during spinal cord regeneration. +genetics_knock down_suppress 30854110 hsa-mir-192 Corneal dystrophy, epithelial basement membrane In contrast, knockdown of miR +genetics_knock down_suppress 30854107 hsa-mir-135a Stomach Neoplasms Western Blot assay showed that knockdown of SNHG16 decreased the expression of JAK2 and p-STAT3 in GC cells while miR-135a can offset the facilitated impact. +other 30854091 hsa-mir-378 Stomach Neoplasms Survival analysis showed that four lncRNAs (LINC01254, LINC01287, LINC01524, U95743.1) and four miRNAs (miR-302a, miR-302b, miR-1286, miR-378g) were associated with overall survival of GC with Hp infection. +genetics_overexpression_promote 30854076 hsa-mir-544 Thyroid Carcinoma, Anaplastic It was further demonstrated that YY1 overexpression rescued the inhibitory effect of progression induced by miR-544 in ATC cells. +transcription factor target 30854070 hsa-mir-20b Carcinoma, Hepatocellular In conclusion, miR-20b may promote H22 cell proliferation by targeting PTEN, providing a rationale for further study investigating novel therapeutic strategies for liver cancer. +genetics_knock down_promote 30854038 hsa-mir-16 Ovarian Neoplasms The results of the present study demonstrated that miR-16 expression is downregulated in the ovarian cancer SKOV3 and OVCAR3 cell lines compared with that in normal ovarian epithelial cells (OECs). +other 30854012 hsa-mir-486 Arthritis, Gouty, Chronic 5p levels in patients with CGA were lower than in controls (P < 0.05). +other 30854012 hsa-mir-339 Arthritis, Gouty, Chronic 5p levels in patients with CGA were lower than in controls (P < 0.05). +other 30854012 hsa-mir-361 Arthritis, Gouty, Chronic 5p levels in patients with CGA were lower than in controls (P < 0.05). +lncRNA target 30853664 hsa-mir-7 Colorectal Neoplasms Furthermore, we showed that TINCR might promote CRC progression via miR5p-mediated PI3K/Akt/mTOR signaling pathway. +other 30853598 hsa-mir-370 Pituitary Neoplasms 3p/HMGA2 signaling pathway is involved in tumor growth and invasiveness of NFPAs. +other 30853453 hsa-mir-34a Fibrosis, Renal These findings suggested that miR-34a plays an important role in the progression of renal fibrosis, which provides new insights into the pathogenesis and treatment of CKD. +other 30853447 hsa-mir-1 Heart Failure It has been shown that miR-1 can reverse cardiac hypertrophy during the compensatory phase of HF development, but it is unknown whether miR-1 can still reverse cardiac dysfunction and improve cardiac remodeling after HF progresses to the decompensation stage. +transcription factor target 30853343 hsa-mir-205 Hypertension, Pulmonary 5p/MICAL2/Erk1/2 may serve as an ideal therapeutic target to PAH treatment. +lncRNA target 30853185 hsa-mir-6506 Stomach Neoplasms Taken together, our study revealed that hsa_circ_0001368 plays a tumor-suppression role in GC via the miR5p/FOXO3 axis and may serve as a potential target for GC therapy. +genetics_GWAS 30852977 hsa-mir-373 Esophageal Squamous Cell Carcinoma CONCLUSIONS: This study shows that DNA epigenetic modification in the miR +transcription factor target 30852906 hsa-mir-222 Ileus, Post-Operative In this study, we investigated whether miR-222, c-kit and endothelial nitric oxide synthase (eNOS) are involved in the putative effects of acupuncture on ICC recovery. CONCLUSION: Acupuncture at ST36, SP6 and LR3 facilitates ICC recovery and improves post-operative GI motility in part through regulation of miR-222, c-kit and eNOS. +genetics_GWAS 30852714 hsa-mir-4660 Hyperoxaluria, Primary CONCLUSION: MiR-4660 is probably a new biomarker for mutation-negative idiopathic oxalosis by regulating the post-transcription of AGXT, providing a potential treatment target of mutation-negative idiopathic oxalosis. +genetics_GWAS 30852614 hsa-mir-149 Uterine Cervical Neoplasms The results showed that the miR-149 rs2292832 TC/CC genotypes were associated with a 21% increased risk of CC compared with the TT genotype [odds ratio (OR) = 1.21, 95% confidence interval (CI) = 1.00-1.47]. Therefore, the rs2292832 polymorphism might influence CC susceptibility through modulation of the procession of pre-miR-149 to mature miRNAs. +lncRNA target 30852380 hsa-mir-582 Prostatic Neoplasms 5p attenuated bone metastasis of PCa via inhibiting transforming growth factor beta (TGF-beta) signaling by simultaneously targeting several components of TGF-beta signaling, including SMAD2, SMAD4, TGF-beta receptor I (TGFBRI), and TGFBRII. +circulation_biomarker_diagnosis_ns 30852102 hsa-mir-155 Hepatitis C Intriguingly, the circulating levels of miR-155 were inversely correlated with HOMA-IR, fasting blood glucose and HbA1c levels. This may suggest a role for miR-155 in the pathogenesis of IR caused by HCV. +other 30852102 hsa-mir-34a Hepatitis C The objective of this study was to investigate the levels of both miR-155 and miR-34a in sera of chronic HCV patients with or without T2D. RESULTS: Our results revealed significantly higher levels of both miR-155 and miR-34a in chronic HCV patients compared to healthy control subjects. +lncRNA target 30851548 hsa-mir-136 Carcinoma, Non-Small-Cell Lung Furthermore, SUMO1P3 promoted NSCLC cell migration and invasion via regulating miR-136. +genetics_overexpression_promote 30851425 hsa-mir-622 Colorectal Neoplasms We found that overexpression of miR-622 inhibited CRC angiogenesis in vitro, according to suppression of proliferation, migration, tube formation, and invasiveness of human umbilical vein endothelial cells (HUVECs) treated with a tumor cell-conditioned medium derived from Caco-2 or HT-29 cells. +lncRNA target 30851420 hsa-mir-221 Breast Neoplasms The current study reveals that the TGF-beta1/miR-200s/miR-221/DNMT3B regulatory loop is responsible for the maintenance of CAFs status and is also necessary for CAF function in promoting malignance of breast cancer, which provides a potential target for CAF-driven therapeutic strategy. +lncRNA target 30851420 hsa-mir-200 Breast Neoplasms The current study reveals that the TGF-beta1/miR-200s/miR-221/DNMT3B regulatory loop is responsible for the maintenance of CAFs status and is also necessary for CAF function in promoting malignance of breast cancer, which provides a potential target for CAF-driven therapeutic strategy. +genetics_knock down_promote 30851271 hsa-mir-34a Glioma HMGA2 knockdown or miR-34a-5p overexpression inhibited tumor growth and enhanced TMZ-mediated anti-tumor effect in glioma xenograft models. +lncRNA target 30851060 hsa-mir-20 Stomach Neoplasms In conclusion, crocin inhibits the EMT, migration, and invasion of gastric cancer cells, and this activity is mediated through miR-320/KLF5/HIF-1 signaling. +exosome 30850595 hsa-mir-375 Breast Neoplasms Here we report that breast cancer cells have a high constitutive expression of miR-375, which is released as a non-exosome entity during apoptosis. +other 30850365 hsa-mir-15b Head and Neck Neoplasms CONCLUSION miR-15b-5p represents a potentially helpful biomarker for individualized treatment decisions concerning the management of HNSCC patients. +genetics_GWAS 30850350 hsa-mir-4739 Pleural Diseases Investigation on the clinical specimens revealed that high levels of miR-4739 and low levels of bone morphogenetic protein 7 (BMP-7) associated with pleural fibrosis in patients. +lncRNA target 30850243 hsa-mir-132 Neuroblastoma In the current study, we explored the mechanisms by which microRNA-132 (miR-132) regulated the neurotoxicity of human neuroblastoma cells (SH-SY5Y) induced by bupivacaine (BUP). CONCLUSION: In the present study, miR-132 played important roles in regulating BUP-induced neurotoxicity through IGF1R and may act as a promising molecular target for the treatment of human neurotoxicity induced by BUP. +circulation_biomarker_diagnosis_ns 30850242 hsa-mir-17 Lipidoses 5p was highly expressed with lowered ATP-binding cassette transporterA1 (ABCA1) level in the peripheral blood leucocytes (PBLs) of AS patients. +circulation_biomarker_diagnosis_ns 30850242 hsa-mir-17 Inflammation 5p was highly expressed with lowered ATP-binding cassette transporterA1 (ABCA1) level in the peripheral blood leucocytes (PBLs) of AS patients. +circulation_biomarker_diagnosis_ns 30850242 hsa-mir-17 Atherosclerosis 5p was highly expressed with lowered ATP-binding cassette transporterA1 (ABCA1) level in the peripheral blood leucocytes (PBLs) of AS patients. +circulation_biomarker_diagnosis_up 30849960 hsa-mir-148b Carcinoma, Non-Small-Cell Lung Then, the underlying mechanisms were studied by transfecting recombinant plasmids containing a miR-148b mimic or a negative control (NC) mimic (shRNA control) into NSCLC cell lines PC14/B and A549 cells. +transcription factor target 30849921 hsa-mir-429 Thyroid Neoplasms In conclusion, these data indicated that miR-429 could act as a tumour suppressor miRNA and contribute to the development and progression and metastasis of thyroid cancer. +other 30849637 hsa-mir-16-1 esophagus adenocarcinoma 1 expression is an independent prognostic marker in terms of OS (HR:1.688, 95%CI: 1.085-2.627, p = 0.020) in EAD patients. +other 30849637 hsa-mir-15a esophagus adenocarcinoma 1 expression is an independent prognostic marker in terms of OS (HR:1.688, 95%CI: 1.085-2.627, p = 0.020) in EAD patients. +other 30849635 hsa-mir-4652 Meningioma Bioinformatics analysis and mechanism experiments demonstrated that LINC00702 acted as the molecular sponge of miR3p to upregulate ZEB1 in malignant meningioma. +lncRNA target 30849540 hsa-mir-889 Carcinoma, Non-Small-Cell Lung The current study suggests that miR-889 may play a potential therapeutic role for NSCLC by targeting KLF9 to control NSCLC proliferation and migration. +circulation_biomarker_diagnosis_up 30849539 hsa-mir-21 Coronary Stenosis Expression pattern of miR-21, miR-25 and PTEN in peripheral blood mononuclear cells of patients with significant or insignificant coronary stenosis. This study explored PBMC expression levels of miR-21, miR-25 and PTEN in patients with angiographically proven significant coronary stenosis (the CAD group), patients with insignificant coronary stenosis (the ICAD group) and healthy subjects, and assessed potentials of PBMC expressions in discriminating groups of study subjects. +circulation_biomarker_diagnosis_up 30849539 hsa-mir-25 Coronary Stenosis Expression pattern of miR-21, miR-25 and PTEN in peripheral blood mononuclear cells of patients with significant or insignificant coronary stenosis. This study explored PBMC expression levels of miR-21, miR-25 and PTEN in patients with angiographically proven significant coronary stenosis (the CAD group), patients with insignificant coronary stenosis (the ICAD group) and healthy subjects, and assessed potentials of PBMC expressions in discriminating groups of study subjects. +genetics_overexpression_promote 30849536 hsa-mir-99b Carcinoma, Hepatocellular In the present study, we demonstrated for the first time that miR-99b-3p was overexpressed in HCC by our findings and data from GEO datasets. +lncRNA target 30849310 hsa-mir-29a Tendinopathy These findings suggest miR-29a contributes to tendon homeostasis and can serve as a potential therapeutic target in treating tendinopathy. +circulation_biomarker_diagnosis_up 30848985 hsa-mir-181b Behcet Syndrome Serum levels of miR-181b, hs-CRP, TNF-alpha, IL-6, E-selectin, and VCAM-1 were significantly higher in patients than in controls, but no significant difference was observed between the active and inactive BD groups. +circulation_biomarker_diagnosis_ns 30848661 hsa-mir-155 Cystic Fibrosis Top-ranked miRNAs that increased in response to CF plasma (adjusted P < 0.05) included miR-155 and miR-146a, which target many immune-related genes, such as IL-8. +circulation_biomarker_diagnosis_ns 30848661 hsa-mir-146a Cystic Fibrosis Top-ranked miRNAs that increased in response to CF plasma (adjusted P < 0.05) included miR-155 and miR-146a, which target many immune-related genes, such as IL-8. +exosome 30848579 hsa-mir-146a Multiple Sclerosis, Relapsing-Remitting A statistically significant increased expression of miR-326 in Tconv-derived exosomes was observed in RRMS patients as compared with controls (7.5+/-1.88vs 2.51+/-0.9 p=0.03), On the contrary, no differences were found in the expression levels of miR-155, miR-146a, and miR-29a, in Tconv-derived exosomes of patients as compared with controls (p>0.05). +exosome 30848579 hsa-mir-326 Multiple Sclerosis, Relapsing-Remitting Therefore, miR-326 containing exosomes might also be a potential clinical target in course of MS. +exosome 30848579 hsa-mir-155 Multiple Sclerosis, Relapsing-Remitting A statistically significant increased expression of miR-326 in Tconv-derived exosomes was observed in RRMS patients as compared with controls (7.5+/-1.88vs 2.51+/-0.9 p=0.03), On the contrary, no differences were found in the expression levels of miR-155, miR-146a, and miR-29a, in Tconv-derived exosomes of patients as compared with controls (p>0.05). +exosome 30848579 hsa-mir-29a Multiple Sclerosis, Relapsing-Remitting A statistically significant increased expression of miR-326 in Tconv-derived exosomes was observed in RRMS patients as compared with controls (7.5+/-1.88vs 2.51+/-0.9 p=0.03), On the contrary, no differences were found in the expression levels of miR-155, miR-146a, and miR-29a, in Tconv-derived exosomes of patients as compared with controls (p>0.05). +other 30848548 hsa-mir-96 Dyslipidemias These results suggested that the miR-96 is involved in the protective effect of GSPE against HFD-induced dyslipidemia. +transcription factor target 30848506 hsa-mir-1224 Acute Liver Injury Downregulation of miR-1224 protects against oxidative stress-induced acute liver injury by regulating hepatocyte growth factor. CONCLUSION Downregulation of miR-1224 could attenuate oxidative stress-induced inhibition of viability and increase of apoptosis in hepatocytes by targeting HGF, which may provide a target for potential therapy of acute liver injury. +genetics_overexpression_promote 30848438 hsa-mir-340 Neuralgia 5p overexpression also decreased inflammation as well as expression levels of COX-2, IL-1beta, TNF-alpha and IL-6 in CCI rats. +other 30848162 hsa-mir-143 Poorly Differentiated Thyroid Gland Carcinoma In summary, our results suggest that miR-143 can be an alternative treatment for PDTC and the specific assessment of therapeutic response to miR-143 can be achieved by (18)F-FDG microPET/CT in advanced thyroid carcinoma xenografts. +genetics_GWAS 30848099 hsa-mir-100 Precursor Cell Lymphoblastic Leukemia-Lymphoma CONCLUSION: Our study suggested that there was significant association between the polymorphisms in miR-100 (rs543412) and decreased susceptibility to childhood ALL. +lncRNA target 30847937 hsa-mir-21 Diabetic Nephropathies Transforming growth factor-beta1 (TGF-beta1)/Smad3 signaling is aberrantly induced in DN, leading to elevated microRNA-21 (miR-21) expression and tissue fibrosis. Our results indicated that SnoN suppresses the development of DN as well as renal fibrosis by downregulating miR-21, and therefore represents a novel and promising therapeutic target for DN. +transcription factor target 30847933 hsa-mir-184 Breast Neoplasms In vitro functional assays using a combination of miR5p inhibitor and miR-181c-3p mimic synergistically decreased adipocytes-induced cell proliferation and invasive capacity of BCa cells. +transcription factor target 30847933 hsa-mir-181c Breast Neoplasms In vitro functional assays using a combination of miR5p inhibitor and miR-181c-3p mimic synergistically decreased adipocytes-induced cell proliferation and invasive capacity of BCa cells. +transcription factor target 30847744 hsa-mir-223 Cartilage Diseases 3p/NLRP3 signaling could be used as a potential target of SIN for the treatment of OA. +transcription factor target 30847421 hsa-mir-29b Wounds and Injuries miR-29b affected inflammation and adverse wound healing through its targets pentraxin-3 and dipeptidyl-peptidase 4. +transcription factor target 30847421 hsa-mir-29b Inflammation miR-29b affected inflammation and adverse wound healing through its targets pentraxin-3 and dipeptidyl-peptidase 4. +transcription factor target 30847385 hsa-mir-30 Pancreatic Carcinoma 5p exerts a tumor-suppressive function in PC cell lines. +circulation_biomarker_diagnosis_ns 30847025 hsa-mir-21 Breast Neoplasms We aimed to evaluate the differential expression of miR-23b and miR-190 which are involved in tumor dormancy, miR-21 involved in metastasis and miR-200b and miR-200c involved in epithelial-mesenchymal transition (EMT) and metastasis, in the plasma of patients with early and metastatic breast cancer (MBC). Results miR-21 (p < 0.001), miR-23b (p = 0.033), miR-200b (p < 0.001) and miR-200c (p < 0.001) expression was higher in metastatic compared to early breast cancer. +circulation_biomarker_diagnosis_ns 30847025 hsa-mir-200c Breast Neoplasms We aimed to evaluate the differential expression of miR-23b and miR-190 which are involved in tumor dormancy, miR-21 involved in metastasis and miR-200b and miR-200c involved in epithelial-mesenchymal transition (EMT) and metastasis, in the plasma of patients with early and metastatic breast cancer (MBC). Results miR-21 (p < 0.001), miR-23b (p = 0.033), miR-200b (p < 0.001) and miR-200c (p < 0.001) expression was higher in metastatic compared to early breast cancer. +circulation_biomarker_diagnosis_ns 30847025 hsa-mir-23b Breast Neoplasms We aimed to evaluate the differential expression of miR-23b and miR-190 which are involved in tumor dormancy, miR-21 involved in metastasis and miR-200b and miR-200c involved in epithelial-mesenchymal transition (EMT) and metastasis, in the plasma of patients with early and metastatic breast cancer (MBC). Results miR-21 (p < 0.001), miR-23b (p = 0.033), miR-200b (p < 0.001) and miR-200c (p < 0.001) expression was higher in metastatic compared to early breast cancer. +circulation_biomarker_diagnosis_ns 30847025 hsa-mir-200b Breast Neoplasms We aimed to evaluate the differential expression of miR-23b and miR-190 which are involved in tumor dormancy, miR-21 involved in metastasis and miR-200b and miR-200c involved in epithelial-mesenchymal transition (EMT) and metastasis, in the plasma of patients with early and metastatic breast cancer (MBC). Results miR-21 (p < 0.001), miR-23b (p = 0.033), miR-200b (p < 0.001) and miR-200c (p < 0.001) expression was higher in metastatic compared to early breast cancer. +lncRNA target 30846940 hsa-mir-409 Osteosarcoma 3p in OS cells may be exerted via negative regulation of ZEB1. +genetics_overexpression_suppress 30846474 hsa-mir-320d Pulmonary Disease, Chronic Obstructive Overexpression of miR-320d in BEAS-2B cells dampened cigarette smoke extract-induced pro-inflammatory activity via inhibition of nuclear factor-B.Collectively, we identified miR-320d as a novel mediator of ICS, regulating the pro-inflammatory response of the airway epithelium. +other 30846207 hsa-mir-137 autosomal recessive congenital bilateral absence of vas deferens Our study provides novel mechanistic insights into the cross-talk between OIP5-AS1, miR-137, and TWIST11, shedding light on the therapy for CAVD. +lncRNA target 30844757 hsa-mir-10b Prostatic Neoplasms Afterwards, we found miR-10b expression was positively correlated with lncRNA CHRF expression, and miR-10b inhibition could reverse the effects of lncRNA CHRF on PC3 and LNCaP cell proliferation and EMT. LncRNA CHRF silence repressed proliferation and EMT while promoted apoptosis in PC3 cells via positive regulation of miR-10b. +lncRNA target 30844685 hsa-mir-486 Cardiomyopathies Moreover, the myocardial injury caused by ischemia/reperfusion was repaired by BMSC-exo which activates the PI3K/AKT pathway via miR5p in vivo. +genetics_knock down_promote 30844657 hsa-mir-575 Stomach Neoplasms Knockdown or overexpression of miR-575 in MGC-803 cells negatively regulated PTEN expression. +circulation_biomarker_diagnosis_ns 30844585 hsa-mir-367 Liver Injury Only the expression of serum miRNA +circulation_biomarker_diagnosis_ns 30844585 hsa-mir-122 Liver Injury Only the expression of serum miRNA +other 30844478 hsa-let-7e Cardiomegaly By combining node scores derived from motif-based centrality, active pathways, and k-shell index, our approach was able to prioritize biologically meaningful TFs (e.g., MYC, SP1, AKR1B1, EGR1, NFKB1, and ETS1) and miRNAs (e.g., hsa-let-7i-5p, hsa-let-7e-5p, hsa-miR-21a-5p, and hsa-miR-27b-5p) as central nodes in the network and point potential active regulatory pathways in CH. +other 30844478 hsa-mir-27b Cardiomegaly By combining node scores derived from motif-based centrality, active pathways, and k-shell index, our approach was able to prioritize biologically meaningful TFs (e.g., MYC, SP1, AKR1B1, EGR1, NFKB1, and ETS1) and miRNAs (e.g., hsa-let-7i-5p, hsa-let-7e-5p, hsa-miR-21a-5p, and hsa-miR-27b-5p) as central nodes in the network and point potential active regulatory pathways in CH. +other 30844478 hsa-mir-21 Cardiomegaly By combining node scores derived from motif-based centrality, active pathways, and k-shell index, our approach was able to prioritize biologically meaningful TFs (e.g., MYC, SP1, AKR1B1, EGR1, NFKB1, and ETS1) and miRNAs (e.g., hsa-let-7i-5p, hsa-let-7e-5p, hsa-miR-21a-5p, and hsa-miR-27b-5p) as central nodes in the network and point potential active regulatory pathways in CH. +other 30844478 hsa-let-7i Cardiomegaly By combining node scores derived from motif-based centrality, active pathways, and k-shell index, our approach was able to prioritize biologically meaningful TFs (e.g., MYC, SP1, AKR1B1, EGR1, NFKB1, and ETS1) and miRNAs (e.g., hsa-let-7i-5p, hsa-let-7e-5p, hsa-miR-21a-5p, and hsa-miR-27b-5p) as central nodes in the network and point potential active regulatory pathways in CH. +lncRNA target 30844369 hsa-mir-1 Osteosarcoma 5p suppressed proliferation, invasion and tumorigenicity of OS cells through promoting AXIN1. +lncRNA target 30844301 hsa-mir-4429 Carcinoma, Renal Cell Conclusions: Present study revealed that miR-4429 suppressed ccRCC tumor progression and EMT by targeting CDK6. +transcription factor target 30844143 hsa-mir-192 Breast Neoplasms 5p might serve as a novel target for reversing DOX resistance and controlling breast tumor growth. +genetics_GWAS 30843663 hsa-mir-125a Carcinoma, Non-Small-Cell Lung To investigate the associations between the functional single nucleotide polymorphisms (SNPs) in the miR-125 family and the survival of non-small cell lung cancer (NSCLC) patients, we systematically selected six functional SNPs located in three pre-miRNAs (miR-125a, miR-125b-1, miR-125b-2). +genetics_knock down_suppress 30843652 hsa-mir-205 Melanoma In vitro, NORAD knockdown significantly inhibited migration and invasion of malignant melanoma cells and elevated the expression of miR-205, there was an interaction between miR-205 and NORAD in the RNA-induced silencing complex. +lncRNA target 30843262 hsa-mir-876 Stomach Neoplasms TMED3 siRNA inhibited miR +circulation_biomarker_diagnosis_ns 30842440 hsa-mir-375 Diabetes Mellitus, Type 2 Males had a high diabetes incidence that was increased by early overnutrition, characterized by a progressive increase in insulin secretion as well as beta cell death, indicated by histological analysis and increased circulating miR-375 levels. +other 30842352 hsa-mir-15b Diabetes Mellitus However, the mechanisms underlying the regulatory effects of miR-15b-5p on patients with diabetes remain unclear. +transcription factor target 30842352 hsa-mir-15b Norrie disease Taken together, miR-15b-5p might be a potential therapeutic target for the treatment of patients with DN. +genetics_knock down_promote 30841958 hsa-mir-374a Glioma More importantly, we found that knockdown of miR-374a was able to enhance the etoposide-induced cytotoxicity against glioma cells. +other 30841483 hsa-mir-146a Osteoarthritis Outcomes were validated by qRT-PCR on miR-146a-5p, reported to be ASC-EVs enriched and involved in OA. +lncRNA target 30841471 hsa-mir-10a Carcinoma, Renal Cell CONCLUSIONS: Taken together, our findings suggest that ZFAS1 promotes growth and metastasis of ccRCC via targeting miR-10a/SKA1 pathway, which may represent a novel therapeutic target or biomarker for ccRCC. +genetics_overexpression_promote 30841468 hsa-mir-345 Pancreatic Carcinoma 5p overexpression. +genetics_overexpression_suppress 30841464 hsa-mir-145 Acute Lung Injury Additionally, TGFBR2 overexpression partially abrogated miR +genetics_overexpression_suppress 30841464 hsa-mir-145 Sepsis Additionally, TGFBR2 overexpression partially abrogated miR +circulation_biomarker_diagnosis_up 30841451 hsa-mir-135a Adenocarcinoma of Lung Mechanism investigation revealed that circ_0001946 was located in the cytoplasm of LAC cells and acted as a molecular sponge of miR-135a-5p to upregulate Sirtuin 1 (SIRT1) expression. Rescue assays further validated the role of circ_0001946-miR-135a-5p-SIRT1 axis in LAC progression. +lncRNA target 30841423 hsa-mir-183 Carcinoma, Non-Small-Cell Lung 5p is required for NSCLC development through the suppressing PTEN, and might be a promising target in the diagnosis and treatment of lung cancer in the future. +lncRNA target 30841025 hsa-mir-197 Carcinoma, Non-Small-Cell Lung In conclusion, MALAT1 could alter chemo-resistance of NSCLC cells by targeting miR +lncRNA target 30840927 hsa-mir-510 Carcinoma, Non-Small-Cell Lung Moreover, bioinformatics and luciferase reporter assays demonstrated that LINC00702 functioned as a competing endogenous RNA (ceRNA) for miR-510 in NSCLC, and upregulated its target gene PTEN. CONCLUSION: Our results indicated that LINC00702 modulated the expression of PTEN gene by acting as a ceRNA for miR-510 in NSCLC. +other 30840889 hsa-mir-432 Breast Neoplasms Levels of miR5p are higher in primary breast cancers demonstrating CDK4/6 resistance compared to those that are sensitive. +transcription factor target 30840298 hsa-mir-20 Iron Metabolism Disorders The inhibition of mir-320 expression can enhance OS potency of the myocardium, alleviate I-R injury or reduce cell apoptosis by facilitating Nrf2 expression. +circulation_biomarker_diagnosis_up 30840285 hsa-mir-451a Lymphoma, Large B-Cell, Diffuse CONCLUSIONS: Serum exosome miR-451a has moderate diagnostic efficiency for DLBCL. +genetics_overexpression_promote 30840284 hsa-mir-592 Leukemia, Myeloid, Acute Finally, ROCK1 overexpression rescued the effect of miR +genetics_overexpression_promote 30840282 hsa-mir-216a Glioma CONCLUSIONS: GHET1 overexpression increased viability, migration and invasion of U251 cells by down-regulating miR-216a. +circulation_biomarker_prognosis_up 30840281 hsa-mir-30 Breast Neoplasms CONCLUSIONS: MiR-330 is highly expressed in cancer tissues and serum of patients with breast cancer, and it can promote the axillary lymph node metastasis, which is an important factor affecting the prognosis of breast cancer patients. +genetics_knock down_promote 30840280 hsa-mir-106a Breast Neoplasms In addition, microRNA-106a knockdown model was constructed by transfecting small interfering RNA in BC cell lines including MCF-7 and SKBR3. +genetics_overexpression_promote 30840278 hsa-mir-204 Adenocarcinoma of Lung Moreover, overexpression of miR-204 inhibited metastasis and EMT of lung adenocarcinoma cells. +circulation_biomarker_diagnosis_up 30840277 hsa-mir-224 Carcinoma, Non-Small-Cell Lung The quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) technique was used to test the expressions of miRNA-99a and miRNA-224 in the serum of the patients in the two groups, and the relationship between the expression levels of miRNA-99a and miRNA-224 and the clinicopathological features of the patients with NSCLC was analyzed; the correlation between the expression of miRNA-99a and the expression of miRNA-224 in NSCLC was also analyzed. +other 30840276 hsa-mir-211 Carcinoma, Non-Small-Cell Lung 3p. +genetics_knock down_promote 30840272 hsa-mir-487a Esophageal Squamous Cell Carcinoma Transwell assay demonstrated that co-transfection with overexpression plasmid of p62 and si-microRNA-487a in EC cells markedly decreased invasive and migratory abilities. +lncRNA target 30840271 hsa-mir-182 Colorectal Neoplasms The cell proliferation, invasion and migration ability of CRC cells were significantly inhibited after the up-regulation of miR +genetics_overexpression_promote 30840270 hsa-mir-198 Colorectal Neoplasms Overexpression of miR-198 inhibits CRC cell proliferation and colony formation but promotes apoptosis. +lncRNA target 30840269 hsa-mir-34a Colorectal Neoplasms CONCLUSIONS: According to the results, this work uncovers a previously unappreciated ZDHHC8P1/miR-34a regulatory axis in controlling progression and metastasis of CRC and suggests that interfering with lncRNA-ZDHHC8P1 and miR-34a could be a viable approach to treat late-stage metastatic CRC patients. +other 30840268 hsa-let-7e Liver Neoplasms ZEB1 causes the production of hsa-microRNA-99b/let-7e/microRNA-125a cluster and promotes invasion of liver cancer cells. OBJECTIVE To explore the role of hsa-microRNA-99b/let-7e/microRNA-125a cluster in the progression of liver cancer and its possible regulatory mechanisms. +other 30840268 hsa-mir-99b Liver Neoplasms ZEB1 causes the production of hsa-microRNA-99b/let-7e/microRNA-125a cluster and promotes invasion of liver cancer cells. OBJECTIVE To explore the role of hsa-microRNA-99b/let-7e/microRNA-125a cluster in the progression of liver cancer and its possible regulatory mechanisms. +other 30840268 hsa-mir-125a Liver Neoplasms ZEB1 causes the production of hsa-microRNA-99b/let-7e/microRNA-125a cluster and promotes invasion of liver cancer cells. OBJECTIVE To explore the role of hsa-microRNA-99b/let-7e/microRNA-125a cluster in the progression of liver cancer and its possible regulatory mechanisms. +lncRNA target 30840264 hsa-mir-29b Osteosarcoma We also found that exogenous miR-29b reduces the proliferation, promotes the apoptosis and upregulates the sensitivity to chemotherapy (doxorubicin) of osteosarcoma cells via direct targeting of the MMP-9. +lncRNA target 30840261 hsa-mir-218 Endometrial Neoplasms CONCLUSIONS: In the present study, we elucidated that miR-218 served as a tumor suppressor in EC by negatively regulating ADD2. +lncRNA target 30840259 hsa-mir-495 Ovarian Neoplasms CONCLUSIONS: We found that the high expression of lnc00908 can promote the proliferation and migration abilities of OC cells through sponging microRNA +other 30840191 hsa-mir-16 Breast Neoplasms We conclude that miR-16 is not a suitable normalizer for the relative expression profiling of miRNAs in luminal A breast cancer patients. +other 30840186 hsa-mir-143 Aortic Valve Stenosis We identified miR-21, miR-24, and miR-143 to be highly upregulated in stenotic aortic valves. +other 30840186 hsa-mir-21 Aortic Valve Stenosis We identified miR-21, miR-24, and miR-143 to be highly upregulated in stenotic aortic valves. +other 30840186 hsa-mir-24 Aortic Valve Stenosis We identified miR-21, miR-24, and miR-143 to be highly upregulated in stenotic aortic valves. +transcription factor target 30839116 hsa-mir-652 Pneumonia, Mycoplasma 3p is dysregulated in PE and regulates the cellular function of trophoblast cells remains unknown. +genetics_overexpression_promote 30839051 hsa-mir-155 Triple Negative Breast Neoplasms LncRNA NEF overexpression inhibited the migration and invasion of TNBC cells, while miRNA-155 overexpression promoted the migration and invasion of TNBC cells, but showed no significant effects on cancer cell proliferation. +lncRNA target 30838890 hsa-mir-122 Acute Lung Injury We assessed miR-122 expression in patients receiving the two acetylcysteine regimens and in a separate group with acute liver injury (ALI). Median normalized miR-122 Ct after 20 h of acetylcysteine was 2.2 (IQR 1.9, 6.4), 1.1 (0.7, 2.9), 63.9 (2.5, 168), 123.2 (40.9, 207.8) in the NACSTOP-abbreviated, NACSTOP-control, ALI and hepatotoxicity groups, respectively. +lncRNA target 30838890 hsa-mir-122 Chemical and Drug Induced Liver Injury Median normalized miR-122 Ct after 20 h of acetylcysteine was 2.2 (IQR 1.9, 6.4), 1.1 (0.7, 2.9), 63.9 (2.5, 168), 123.2 (40.9, 207.8) in the NACSTOP-abbreviated, NACSTOP-control, ALI and hepatotoxicity groups, respectively. +other 30838872 hsa-mir-17 nephrotic syndrome type 1 Here, we present evidence for a novel molecular mechanism regulating the self-renewal of nephron progenitors and congenital nephron endowment by the highly conserved miR-17~92 cluster. +lncRNA target 30838724 hsa-mir-455 Pancreatic Carcinoma These results indicate that DLEU2 is an important promoter of PC development, and targeting the DLEU2/miR-455/SMAD2 pathway could be a promising therapeutic approach in the treatment of PC. +lncRNA target 30838699 hsa-mir-641 Osteosarcoma Mechanistic studies showed that DLX6-AS1 regulated OS cell proliferation, invasion, and migration via regulating HOXA9 by acting as a ceRNA for miR-641. Our results suggested that DLX6-AS1 functions as a ceRNA by targeting miR-641/HOXA9 signal pathway to suppress OS cell proliferation and metastasis. +other 30837842 hsa-mir-146a Fever In addition, after TNF-alpha exposure we also observed significant upregulation of two microRNAs (miRNAs; miR-34a and miR-146a) associated with mitochondrial dysfunction in secreted EVs. +other 30837842 hsa-mir-34a Fever In addition, after TNF-alpha exposure we also observed significant upregulation of two microRNAs (miRNAs; miR-34a and miR-146a) associated with mitochondrial dysfunction in secreted EVs. +other 30837842 hsa-mir-34a Mitochondrial Diseases In addition, after TNF-alpha exposure we also observed significant upregulation of two microRNAs (miRNAs; miR-34a and miR-146a) associated with mitochondrial dysfunction in secreted EVs. +other 30837842 hsa-mir-146a Mitochondrial Diseases In addition, after TNF-alpha exposure we also observed significant upregulation of two microRNAs (miRNAs; miR-34a and miR-146a) associated with mitochondrial dysfunction in secreted EVs. +other 30837840 hsa-mir-137 Seizures Simultaneous antagonism of both microRNA-124 and -137 rescued seizure-induced alterations in NSPC, supporting their coordinated action in the regulation of NSC fate and proliferation and their potential for future seizure therapies. +other 30837840 hsa-mir-124 Seizures Simultaneous antagonism of both microRNA-124 and -137 rescued seizure-induced alterations in NSPC, supporting their coordinated action in the regulation of NSC fate and proliferation and their potential for future seizure therapies. +other 30837665 hsa-mir-125b Hemoglobinuria, Paroxysmal We found differential expression of miRNAs miR-148b-3p, miR3p, miR29b-3p, miR15b-5p, let-7e-5p, miR126-3p, miR-125b-5p and miR-376c-3p as well as hemoglobin, haptoglobin, protein S and C4-binding protein in healthy controls vs PNH patients. +other 30837665 hsa-mir-15b Hemoglobinuria, Paroxysmal We found differential expression of miRNAs miR-148b-3p, miR3p, miR29b-3p, miR15b-5p, let-7e-5p, miR126-3p, miR-125b-5p and miR-376c-3p as well as hemoglobin, haptoglobin, protein S and C4-binding protein in healthy controls vs PNH patients. +other 30837665 hsa-mir-376c Hemoglobinuria, Paroxysmal We found differential expression of miRNAs miR-148b-3p, miR3p, miR29b-3p, miR15b-5p, let-7e-5p, miR126-3p, miR-125b-5p and miR-376c-3p as well as hemoglobin, haptoglobin, protein S and C4-binding protein in healthy controls vs PNH patients. +other 30837665 hsa-mir-29b Hemoglobinuria, Paroxysmal We found differential expression of miRNAs miR-148b-3p, miR3p, miR29b-3p, miR15b-5p, let-7e-5p, miR126-3p, miR-125b-5p and miR-376c-3p as well as hemoglobin, haptoglobin, protein S and C4-binding protein in healthy controls vs PNH patients. +other 30837665 hsa-let-7e Hemoglobinuria, Paroxysmal We found differential expression of miRNAs miR-148b-3p, miR3p, miR29b-3p, miR15b-5p, let-7e-5p, miR126-3p, miR-125b-5p and miR-376c-3p as well as hemoglobin, haptoglobin, protein S and C4-binding protein in healthy controls vs PNH patients. +other 30837665 hsa-mir-148b Hemoglobinuria, Paroxysmal We found differential expression of miRNAs miR-148b-3p, miR3p, miR29b-3p, miR15b-5p, let-7e-5p, miR126-3p, miR-125b-5p and miR-376c-3p as well as hemoglobin, haptoglobin, protein S and C4-binding protein in healthy controls vs PNH patients. +other 30837665 hsa-mir-423 Hemoglobinuria, Paroxysmal We found differential expression of miRNAs miR-148b-3p, miR3p, miR29b-3p, miR15b-5p, let-7e-5p, miR126-3p, miR-125b-5p and miR-376c-3p as well as hemoglobin, haptoglobin, protein S and C4-binding protein in healthy controls vs PNH patients. +lncRNA target 30837408 hsa-mir-155 Stomach Neoplasms Through its regulatory effect on autophagy, miR-155 can be used to treat gastric cancer, improve chemotherapy sensitivity and reverse drug resistance. +lncRNA target 30837348 hsa-mir-190a Glioblastoma In conclusion, LINC00657 was effective in inhibiting glioblastoma by acting as a molecular sponge of miR-190a-3p to regulate PTEN expression. +genetics_knock down_promote 30837325 hsa-mir-27 Multiple Myeloma Functional studies demonstrated that miR-27 overexpression promoted MM cell proliferation, facilitated cell cycle progression, and expedited cell migration and invasion; whereas miR-27 knockdown inhibited cell proliferation, induced cell cycle arrest, and slowed down cell motility. +lncRNA target 30837035 hsa-mir-101 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Introducing miR-101 inhibited T-ALL cell proliferation and invasion in vitro and suppressed tumor growth and lung metastasis in vivo. +genetics_overexpression_promote 30837034 hsa-mir-203 Stomach Neoplasms The invasion and EMT of GC cells were suppressed by overexpression of miR-203. +genetics_knock down_promote 30836864 hsa-mir-485 Small Cell Lung Carcinoma 5p reduced cell proliferation, migration, and invasion in vitro, whereas knockdown of miR +other 30836600 hsa-mir-34a Glioblastoma Despite the fact that, due to small sample size, our results should be considered as preliminary, our study suggests that miR-34a is associated with tumor burden and can be important for health-related quality of life, functional status, and mood symptoms of glioblastoma patients. +circulation_biomarker_diagnosis_ns 30836355 hsa-mir-197 Heart Failure 5P is a circulation miRNA that correlates with MF and adverse cardiac events in HF patients under the age of 50 years. +circulation_biomarker_diagnosis_ns 30836355 hsa-mir-197 Cardiomyopathies 5P is a circulation miRNA that correlates with MF and adverse cardiac events in HF patients under the age of 50 years. +other 30835941 hsa-mir-181 Parkinson Disease In the present study, we used a most widely used cell line in study of PD, the SH-SY5Y cells, to investigate mechanisms of chlorpyrifos (CPF) induced cell toxicity and the possible roles of cell pyroptosis and oxidative stress in SH-SY5Y cells, as well as role of miR-181/SIRT1/PGC-1/Nrf2 signaling pathway in this process. +other 30835941 hsa-mir-181 Neuroblastoma In the present study, we used a most widely used cell line in study of PD, the SH-SY5Y cells, to investigate mechanisms of chlorpyrifos (CPF) induced cell toxicity and the possible roles of cell pyroptosis and oxidative stress in SH-SY5Y cells, as well as role of miR-181/SIRT1/PGC-1/Nrf2 signaling pathway in this process. +other 30835743 hsa-mir-7977 Leukemia These results suggest that miR-7977 is a critical factor that regulates the Hippo-YAP signaling pathway in BM-MSCs and may be involved in the upregulation of leukemia-supporting stroma growth. +exosome 30835743 hsa-mir-7977 Leukemia, Myeloid, Acute We previously showed that AML cells release abundant exosomal miR-7977, which, in turn, enters BM mesenchymal stromal cells (MSCs). +circulation_biomarker_diagnosis_up 30835718 hsa-mir-99b Diabetic Nephropathies CONCLUSIONS Serum miR-99b, miR +circulation_biomarker_diagnosis_up 30835718 hsa-mir-20a Diabetic Nephropathies CONCLUSIONS Serum miR-99b, miR +circulation_biomarker_diagnosis_up 30835718 hsa-mir-486 Diabetic Nephropathies CONCLUSIONS Serum miR-99b, miR +circulation_biomarker_diagnosis_up 30835718 hsa-mir-122 Diabetic Nephropathies CONCLUSIONS Serum miR-99b, miR +genetics_knock down_promote 30835506 hsa-mir-183 Diabetic Retinopathy miR-183 overexpression or BTG1 knockdown promoted cell growth and tube formation while it suppressed cell apoptosis of vascular endothelial cells in DR rats. +lncRNA target 30835496 hsa-mir-24 Reperfusion Injury 3p could promote UCP2 expression, which presented cell viability increasing, LDH release and cell apoptosis inhibition in OGD/R condition. +circulation_biomarker_prognosis_ns 30835039 hsa-mir-122 Breast Neoplasms Higher circulating miR-122 levels were found in breast cancer patients than in controls and higher miR-122 levels were observed in patients who experienced metastasis. +lncRNA target 30834693 hsa-mir-148a Colorectal Neoplasms miR-148a suppresses VEGF through down-regulation of the pERK/HIF-1alpha/VEGF pathway and might lead to the inhibition of angiogenesis; miR-148a down-regulation increased the early relapse rate of CRC. +genetics_overexpression_promote 30834596 hsa-mir-503 Diabetic Nephropathies These revealed for the first time that the overexpression of miR-503 promoted podocyte injury via targeting E2F3 in diabetic nephropathy and miR-503/E2F3 axis might represent a pathological mechanism of diabetic nephropathy progression. +lncRNA target 30834525 hsa-mir-144 Nasopharyngeal Carcinoma 3p promotes the progression of NPC by directly targeting PTEN via crosstalk with PI3K-Akt signaling. +circulation_biomarker_diagnosis_ns 30833907 hsa-mir-17 Myocardial Infarction The expression levels of plasma miR +circulation_biomarker_diagnosis_ns 30833907 hsa-mir-145 Myocardial Infarction The expression levels of plasma miR +circulation_biomarker_diagnosis_ns 30833907 hsa-mir-126 Myocardial Infarction The expression levels of plasma miR +genetics_GWAS 30833806 hsa-let-7 Stomach Neoplasms related polymorphism rs10889677 in IL23R is associated with the prognosis of gastric cancer. +other 30833639 hsa-mir-221 Breast Neoplasms This work reveals important differences between HER2- and p95HER2- mediated miRNA changes in breast cancer cells, provides novel mechanistic insight into regulation of MYB family transcription factors by p95HER2, and points to a role for a miR-221/222- MYB family-TIMP2 axis in regulation of motility in breast cancer cells. +other 30833639 hsa-mir-222 Breast Neoplasms This work reveals important differences between HER2- and p95HER2- mediated miRNA changes in breast cancer cells, provides novel mechanistic insight into regulation of MYB family transcription factors by p95HER2, and points to a role for a miR-221/222- MYB family-TIMP2 axis in regulation of motility in breast cancer cells. +circulation_biomarker_diagnosis_ns 30833572 hsa-mir-184 X-linked juvenile retinoschisis 1 In this study, compared with normal pregnant women, the expression of miR-184 in decidual stromal cells (DSCs) and decidual immune cells (DICs), as well as in peripheral blood, from RSA patients was enhanced similarly. +lncRNA target 30833538 hsa-mir-100 Pre-Eclampsia 5p may suppress PE development, while LIF, LINC01492, and hsa_circ_0088196 may promote it though inhibiting miR +genetics_overexpression_promote 30833361 hsa-mir-145 Prostatic Neoplasms 5p overexpression did not significantly affect BRE-AS1. +circulation_biomarker_diagnosis_ns 30833349 hsa-mir-223 Acute Lung Injury However, BHD-derived EV had an increased expression of the proatherogenic miR-223 with respect to healthy subjects or mOL-HDF. The switch from BHD to mOL-HDF significantly reduced systemic inflammation and miR-223 expression in plasma EV, thus improving HUVEC angiogenesis and reducing VSMC calcification. +circulation_biomarker_diagnosis_ns 30833349 hsa-mir-223 Uremia However, BHD-derived EV had an increased expression of the proatherogenic miR-223 with respect to healthy subjects or mOL-HDF. The switch from BHD to mOL-HDF significantly reduced systemic inflammation and miR-223 expression in plasma EV, thus improving HUVEC angiogenesis and reducing VSMC calcification. +genetics_knock down_suppress 30832754 hsa-mir-424 Glioma PVT1 knockdown could negatively regulate miR-424 to inhibit cellular activity, migration, and invasiveness in human gliomas, which explained the oncogenic mechanism of PVT1 in human gliomas. +lncRNA target 30832753 hsa-mir-101 Thyroid Cancer, Papillary Overall, miR-101 exerts oncostatic effects on PTC by downregulating CXCL12 and repressing its downstream Akt and Snail signaling pathways, suggesting that miR-101/CXCL12/Akt or Snail axis may serve as a potential therapeutic target for PTC. +lncRNA target 30832674 hsa-mir-144 Carcinoma, Non-Small-Cell Lung As for the bioinformatics analyses, a total of 37 genes were chosen as the potential targets of miR +lncRNA target 30832601 hsa-mir-204 Glomerulonephritis, IGA Among the 8 miRNA targets chosen for validation study, urinary miR-204, miR-431 and miR-555 remained significantly reduced, and urinary miR-150 level was significantly increased in the IgAN as compared to CTL. +genetics_GWAS 30831320 hsa-mir-192 Colorectal Neoplasms In primary CRCs, increased NID1 expression was associated with p53 mutation and microRNA-192/215 down-regulation. +genetics_GWAS 30831320 hsa-mir-215 Colorectal Neoplasms In primary CRCs, increased NID1 expression was associated with p53 mutation and microRNA-192/215 down-regulation. +other 30831132 hsa-mir-23a Cardiotoxicity PGC-1alpha siRNA was employed to validate the role of miR-23a in Dox-induced cardiotoxicity. +genetics_knock down_promote 30831090 hsa-mir-519d Pancreatic Carcinoma The overexpression of miR-519d-3p significantly inhibited the proliferation and Wnt/-catenin signaling in pancreatic cancer cells, mimicking the similar effect of RPS15A knockdown. +lncRNA target 30831032 hsa-mir-181a Uterine Cervical Neoplasms Overall, our findings showed that SP1-activated LUCAT1 exerts an oncogenic function in CC by binding to miR-181a, suggesting that miR-181a may be a ponderable and promising therapeutic target for CC. +other 30830529 hsa-mir-21 Cardiomyopathies miRNA-21 is connected with cardiac fibrosis. +other 30830529 hsa-mir-15b Heart Diseases This study revealed for the first time that the protective effects of molecular hydrogen on irradiation-induced heart damage may be mediated by regulating miRNA-1, -15b, and -21. +other 30830529 hsa-mir-1 Heart Diseases This study revealed for the first time that the protective effects of molecular hydrogen on irradiation-induced heart damage may be mediated by regulating miRNA-1, -15b, and -21. +other 30830529 hsa-mir-1 Cardiomegaly miRNA-1 is known to be involved in cardiac hypertrophy, and was significantly decreased in the rat myocardium after irradiation. +other 30829008 hsa-mir-26a Carcinoma, Hepatocellular In this work, with the use of newly developed PEGylated biodegradable charged polyester-based vectors (PEG-BCPVs) as the carrier, the miR26a and miR122 codelivering therapeutic strategy (PEG-BCPVs/miR26a/miR122 as the delivery formulation) is successfully developed for efficient treatment of human hepatocellular carcinoma (HCC). +other 30829008 hsa-mir-122 Carcinoma, Hepatocellular In this work, with the use of newly developed PEGylated biodegradable charged polyester-based vectors (PEG-BCPVs) as the carrier, the miR26a and miR122 codelivering therapeutic strategy (PEG-BCPVs/miR26a/miR122 as the delivery formulation) is successfully developed for efficient treatment of human hepatocellular carcinoma (HCC). +other 30828688 hsa-mir-138 Osteoarthritis The goal of this study was to determine the function of miR- 138 in regulating osteogenesis by using human osteoarthritic dedifferentiated chondrocytes (DDCs) as source of inducible cells. +lncRNA target 30828264 hsa-mir-96 Carcinoma, Hepatocellular Conclusion miR-96 exerts carcinogenic effect by activating AKT/GSK-3/-catenin signaling pathway through targeting inhibition of FOXO1 in HCC. +other 30828154 hsa-mir-29a Leukemia, Lymphocytic, Chronic, B-Cell We identified various degrees of upregulated miRNAs (miR-29a, miR-29c, miR-34a, miR-155, miR-146a, and miR-195) and down-regulated ones (miR-15a, miR-16, miR-23b, miR-24, miR-181a, and miR-221) in CLL patients relative to controls. Moreover, we found that miR-15a, miR-16, miR-155, miR-181a, miR-195 and miR-221 were significantly upregulated, while miR-29a and miR-29c were significantly downregulated in ZAP-70 positive CLL patients. +other 30828154 hsa-mir-16 Leukemia, Lymphocytic, Chronic, B-Cell We identified various degrees of upregulated miRNAs (miR-29a, miR-29c, miR-34a, miR-155, miR-146a, and miR-195) and down-regulated ones (miR-15a, miR-16, miR-23b, miR-24, miR-181a, and miR-221) in CLL patients relative to controls. Moreover, we found that miR-15a, miR-16, miR-155, miR-181a, miR-195 and miR-221 were significantly upregulated, while miR-29a and miR-29c were significantly downregulated in ZAP-70 positive CLL patients. +other 30828154 hsa-mir-15a Leukemia, Lymphocytic, Chronic, B-Cell We identified various degrees of upregulated miRNAs (miR-29a, miR-29c, miR-34a, miR-155, miR-146a, and miR-195) and down-regulated ones (miR-15a, miR-16, miR-23b, miR-24, miR-181a, and miR-221) in CLL patients relative to controls. Moreover, we found that miR-15a, miR-16, miR-155, miR-181a, miR-195 and miR-221 were significantly upregulated, while miR-29a and miR-29c were significantly downregulated in ZAP-70 positive CLL patients. +other 30828154 hsa-mir-29c Leukemia, Lymphocytic, Chronic, B-Cell We identified various degrees of upregulated miRNAs (miR-29a, miR-29c, miR-34a, miR-155, miR-146a, and miR-195) and down-regulated ones (miR-15a, miR-16, miR-23b, miR-24, miR-181a, and miR-221) in CLL patients relative to controls. Moreover, we found that miR-15a, miR-16, miR-155, miR-181a, miR-195 and miR-221 were significantly upregulated, while miR-29a and miR-29c were significantly downregulated in ZAP-70 positive CLL patients. +other 30828154 hsa-mir-181a Leukemia, Lymphocytic, Chronic, B-Cell We identified various degrees of upregulated miRNAs (miR-29a, miR-29c, miR-34a, miR-155, miR-146a, and miR-195) and down-regulated ones (miR-15a, miR-16, miR-23b, miR-24, miR-181a, and miR-221) in CLL patients relative to controls. Moreover, we found that miR-15a, miR-16, miR-155, miR-181a, miR-195 and miR-221 were significantly upregulated, while miR-29a and miR-29c were significantly downregulated in ZAP-70 positive CLL patients. +other 30828154 hsa-mir-221 Leukemia, Lymphocytic, Chronic, B-Cell We identified various degrees of upregulated miRNAs (miR-29a, miR-29c, miR-34a, miR-155, miR-146a, and miR-195) and down-regulated ones (miR-15a, miR-16, miR-23b, miR-24, miR-181a, and miR-221) in CLL patients relative to controls. Moreover, we found that miR-15a, miR-16, miR-155, miR-181a, miR-195 and miR-221 were significantly upregulated, while miR-29a and miR-29c were significantly downregulated in ZAP-70 positive CLL patients. +other 30828154 hsa-mir-195 Leukemia, Lymphocytic, Chronic, B-Cell We identified various degrees of upregulated miRNAs (miR-29a, miR-29c, miR-34a, miR-155, miR-146a, and miR-195) and down-regulated ones (miR-15a, miR-16, miR-23b, miR-24, miR-181a, and miR-221) in CLL patients relative to controls. Moreover, we found that miR-15a, miR-16, miR-155, miR-181a, miR-195 and miR-221 were significantly upregulated, while miR-29a and miR-29c were significantly downregulated in ZAP-70 positive CLL patients. +other 30828154 hsa-mir-155 Leukemia, Lymphocytic, Chronic, B-Cell We identified various degrees of upregulated miRNAs (miR-29a, miR-29c, miR-34a, miR-155, miR-146a, and miR-195) and down-regulated ones (miR-15a, miR-16, miR-23b, miR-24, miR-181a, and miR-221) in CLL patients relative to controls. Moreover, we found that miR-15a, miR-16, miR-155, miR-181a, miR-195 and miR-221 were significantly upregulated, while miR-29a and miR-29c were significantly downregulated in ZAP-70 positive CLL patients. +lncRNA target 30827510 hsa-mir-33a Colorectal Neoplasms In addition, PIM3 showed up-regulation with cholesterol treatment, and it was proved to be the target gene of miR-33a by dual luciferase reporter assay, it modulated CRC cells proliferation and apoptosis by phosphorylating p27, p21 and Bad protein. +other 30827272 hsa-mir-192 dystonia 5 The aim of this study was to investigate the expression of MCP-1 under high glucose conditions, as well as the effects of microRNA-192 (miR-192) under these conditions, and to study the regulatory mechanism of MCP-1 in DKD. +lncRNA target 30826633 hsa-mir-27a Urinary Bladder Neoplasms Our mechanistic studies reveal that MEG3, as a ceRNA, inhibits the invasiveness of human bladder cancer cells via negative regulation of c-Myc by competing with PHLPP2 mRNA for miR-27a. +lncRNA target 30826419 hsa-mir-9 Parkinson Disease 5p exerted a neurotoxic role in MPP+-derived PD by directly targeting STAT1, providing a potential therapeutic strategy for patients troubled by PD. +other 30826067 hsa-mir-206 Frontotemporal Dementia After a global miRNA profiling, significant downregulation of miR-663a, miR3p, and miR-206 (p = 0.0001, p = 0.0002, and p = 0.02 respectively) in FTD patients was confirmed when compared with HCs in a larger case-control sample. +other 30826067 hsa-mir-663a Frontotemporal Dementia After a global miRNA profiling, significant downregulation of miR-663a, miR3p, and miR-206 (p = 0.0001, p = 0.0002, and p = 0.02 respectively) in FTD patients was confirmed when compared with HCs in a larger case-control sample. +other 30826067 hsa-mir-502 Frontotemporal Dementia After a global miRNA profiling, significant downregulation of miR-663a, miR3p, and miR-206 (p = 0.0001, p = 0.0002, and p = 0.02 respectively) in FTD patients was confirmed when compared with HCs in a larger case-control sample. +genetics_overexpression_suppress 30826062 hsa-mir-520e Glioma The overexpression of miR-520e repressed the proliferation, colony formation, and invasive potential of glioma cells, while the inhibition of miR-520e showed the opposite effect. +lncRNA target 30825877 hsa-mir-143 Gallbladder Neoplasms CONCLUSIONS: The results of our study reveal a potential ceRNA regulatory pathway in which PVT1 modulates HK2 expression by competitively binding to endogenous miR-143 in GBC cells, which may provide new insights into novel molecular therapeutic targets for GBC. +other 30825668 hsa-mir-181a Leukemia miR-181a is downregulated in leukemia and affects its progression, drug resistance, and prognosis. +genetics_knock down_promote 30825668 hsa-mir-181a Leukemia, Myelogenous, Chronic, BCR-ABL Positive Here, we use a multi-omics approach to demonstrate that protein tyrosine phosphatase, receptor type, f polypeptide, leukocyte common antigen (LAR) interacting protein (liprin), alpha 1 (PPFIA1) is a direct target for miR-181a in CML. Overall, we report a critical regulatory miR-181a/PPFIA1/PARP1/NF-kappaB-P65/KIT axis in CML, and our preclinical study supports that targeted PPFIA1 and PARP1 may serve as a potential CML therapy. +lncRNA target 30825424 hsa-mir-939 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: lncRNA RP5-916L7.2 was up regulated in tumor tissue and positively correlated with tumor stage, and promoted cells proliferation while inhibited cells apoptosis by targeting miR +lncRNA target 30825424 hsa-mir-28 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: lncRNA RP5-916L7.2 was up regulated in tumor tissue and positively correlated with tumor stage, and promoted cells proliferation while inhibited cells apoptosis by targeting miR +tissue_expression_ns 30825291 hsa-mir-200b Endometriosis We found up-regulation of miR-200b and down-regulation of miR-145 and let-7b in endometriotic MSCs. +tissue_expression_ns 30825291 hsa-mir-145 Endometriosis We found up-regulation of miR-200b and down-regulation of miR-145 and let-7b in endometriotic MSCs. +tissue_expression_ns 30825291 hsa-let-7b Endometriosis We found up-regulation of miR-200b and down-regulation of miR-145 and let-7b in endometriotic MSCs. +genetics_GWAS 30825231 hsa-mir-382 Osteoporotic Fractures "One single-nucleotide polymorphism (rs3917) located within the 3'-untranslated region of COL1A2 may ""alter"" binding site of miR-382 and thereby associated with the risk of osteoporotic fracture. The findings showed rs3917 polymorphism interfered with the interaction between COL1A2 mRNA and miR-382, and minor allele is associated with a reduced risk of osteoporotic fracture." +other 30825229 hsa-mir-155 Breast Neoplasms Patients with breast cancer with increased miRNA-21 and miRNA-155 and decreased miRNA-126 expressions had significantly worse disease-free survival, while only miRNA-21 and miRNA-126 showed poor OS (P< 0.005). +other 30825229 hsa-mir-21 Breast Neoplasms Patients with breast cancer with increased miRNA-21 and miRNA-155 and decreased miRNA-126 expressions had significantly worse disease-free survival, while only miRNA-21 and miRNA-126 showed poor OS (P< 0.005). +other 30825229 hsa-mir-126 Breast Neoplasms Patients with breast cancer with increased miRNA-21 and miRNA-155 and decreased miRNA-126 expressions had significantly worse disease-free survival, while only miRNA-21 and miRNA-126 showed poor OS (P< 0.005). +transcription factor target 30825225 hsa-mir-154 Intervertebral Disc Degeneration In conclusion, the results suggested that miR-154 participates in the development of IDD and its effects are mediated via targeting FGF14. +lncRNA target 30825222 hsa-mir-224 Uveal melanoma 5p as a therapeutic and diagnosis target for patients with UM. +lncRNA target 30825207 hsa-mir-5581 Carcinoma, Hepatocellular At length, the rescue assays suggested that LINC00961 functioned in HCC through the miR +lncRNA target 30824765 hsa-mir-193b Liposarcoma We show that all three are directly targeted by miR-193b in liposarcoma. +lncRNA target 30824757 hsa-mir-21 Uremia Taken together, the present results demonstrate that pCS directly induced the proliferation and migration of ccRCC cells through mechanisms involving miR-21/HIF-1alpha signaling pathways. +lncRNA target 30824757 hsa-mir-21 Carcinoma, Renal Cell Taken together, the present results demonstrate that pCS directly induced the proliferation and migration of ccRCC cells through mechanisms involving miR-21/HIF-1alpha signaling pathways. +other 30824586 hsa-mir-363 Lymphoma, Large B-Cell, Diffuse Furthermore, we demonstrated that CACNA1C expression was directly regulated by miR-363 whose high expression is associated with worse prognosis in DLBCL. +circulation_biomarker_diagnosis_ns 30824368 hsa-mir-148a Carcinoma, Hepatocellular The removal of primary HCC tumor led to increased plasma miR-148a levels (P < 0.0001), indicating that miR-148a is a HCC-specific biomarker. +lncRNA target 30824348 hsa-mir-23a Brain Injuries After deep hypothermic circulatory arrest, hippocampal growth arrest-specific 5 expression was significantly enhanced with a robust decrease of hippocampal microRNA-23a expression. CONCLUSIONS: Inhibition of large noncoding RNA growth arrest-specific 5 can provide a powerful cerebroprotection against deep hypothermic circulatory arrest, which may be mediated through microRNA-23a/phosphate and tension homology pathway. +circulation_biomarker_diagnosis_ns 30824230 hsa-mir-122 Liver Failure, Acute The significant positive correlations were observed between hepatic miR-122 and biochemical serum markers and the severity of liver injury in histopathological assessments (P<0.01). +lncRNA target 30823924 hsa-mir-200b Urinary Bladder Neoplasms Moreover, ZEB1-AS1 downregulated the expression of miR-200b, promoted migration, invasion, and proliferation, and inhibited apoptosis in BLCA. +lncRNA target 30823895 hsa-mir-186 Ovarian Neoplasms 5p inhibitors were used to modulate endogenous target expression in EOC cell lines in vitro. +transcription factor target 30823890 hsa-mir-1271 Breast Neoplasms RESULTS: miR-1271 suppresses breast cancer progression and EMT phenotype both in vitro and in vivo by targeting SNAI2. +lncRNA target 30822775 hsa-mir-214 Hirschsprung Disease CONCLUSION: Our results revealed that miR-214 is indeed involved in the pathophysiology of HSCR and suppresses cell proliferation and migration by directly downregulating PLAGL2 in cell models. +transcription factor target 30821549 hsa-mir-21 Spinal Cord Injuries Conclusion: Uba3, Sumo1, Pik3ca and miR-21 targeting Pdcd4 might be responsible for the excitability of motor neurons after spinal cord injury. +genetics_GWAS 30821276 hsa-mir-211 Melanoma CONCLUSIONS Taken together, our findings revealed that epigenetic modification of miR-211 governed melanoma cell chemosensitivity and were involved in the progression of tumorigenesis. +transcription factor target 30821011 hsa-mir-223 Spinal Cord Injuries 3p/RIP3 pathway offers a novel therapeutic target for the protection of spinal neurons after SCI. +lncRNA target 30820984 hsa-mir-148b Myocardial Reperfusion Injury Our work aims to elucidate the effect how microRNA-148b (miR-148b) participated in myocardial ischemia/reperfusion (I/R) injury via regulation of Wnt/beta-catenin signaling pathway. Inhibition of miR-148b improved the antioxidative ability and myocardial cell survival to suppress its apoptosis by activating Wnt/beta-catenin signaling pathway, thus ameliorating the myocardial I/R injury. +genetics_GWAS 30820968 hsa-mir-146a Colonic Neoplasms The presence of rs13281615 G > A polymorphism on PVT1 and the rs2910164 C > G polymorphism on miR-146a contributes to a favorable prognosis in CC patients via modulating the activity of the PVT1/miR-146a/COX2 signaling pathway. +other 30820789 hsa-mir-155 Carcinoma, Pancreatic Ductal Ex-miRs, including ex-miR-21 and ex-miR-155, in pancreatic juice may be developed as biomarkers for PDAC. +other 30820789 hsa-mir-21 Carcinoma, Pancreatic Ductal Ex-miRs, including ex-miR-21 and ex-miR-155, in pancreatic juice may be developed as biomarkers for PDAC. +lncRNA target 30820263 hsa-mir-335 Insulin Resistance 5p) were validated by quantitative-time PCR, and their potential target genes related to IR or glycolipid metabolism were also predicted and presented in this study. +lncRNA target 30820263 hsa-mir-34a Insulin Resistance 5p) were validated by quantitative-time PCR, and their potential target genes related to IR or glycolipid metabolism were also predicted and presented in this study. +lncRNA target 30820263 hsa-mir-149 Insulin Resistance 5p) were validated by quantitative-time PCR, and their potential target genes related to IR or glycolipid metabolism were also predicted and presented in this study. +lncRNA target 30820263 hsa-mir-10b Insulin Resistance 5p) were validated by quantitative-time PCR, and their potential target genes related to IR or glycolipid metabolism were also predicted and presented in this study. +lncRNA target 30820263 hsa-mir-411 Insulin Resistance 5p) were validated by quantitative-time PCR, and their potential target genes related to IR or glycolipid metabolism were also predicted and presented in this study. +lncRNA target 30820263 hsa-mir-592 Insulin Resistance 5p) were validated by quantitative-time PCR, and their potential target genes related to IR or glycolipid metabolism were also predicted and presented in this study. +lncRNA target 30820263 hsa-mir-1a Insulin Resistance 5p) were validated by quantitative-time PCR, and their potential target genes related to IR or glycolipid metabolism were also predicted and presented in this study. +genetics_overexpression_suppress 30820195 hsa-mir-129 Inflammation Furthermore, our results demonstrated that overexpression of Smad3 reversed the inhibition of inflammation and apoptosis by overexpression of miR +lncRNA target 30819403 hsa-mir-212 Osteosarcoma Taken together, ILF3-AS1 displayed its tumor-promotive roles in the progression of osteosarcoma through miR-212/SOX5 axis. +genetics_knock down_suppress 30819221 hsa-mir-384 Pancreatic Carcinoma The knockdown of AFAP1-AS1 or overexpression of miR-384 was confirmed to impair PC cell self-renewal ability, tumorigenicity, invasion, migration and stemness. +other 30819205 hsa-mir-128 Agammaglobulinemia And 77 miRNAs were downregulated with over 1.5-fold change in AGM of which 3, miR-370, miR-26, miR-128 (fold changes are 9.3, 1.8, 1.7 respectively; all P < 0.05) were related to lipid metabolism. +other 30819205 hsa-mir-370 Agammaglobulinemia And 77 miRNAs were downregulated with over 1.5-fold change in AGM of which 3, miR-370, miR-26, miR-128 (fold changes are 9.3, 1.8, 1.7 respectively; all P < 0.05) were related to lipid metabolism. +other 30819205 hsa-mir-26 Agammaglobulinemia And 77 miRNAs were downregulated with over 1.5-fold change in AGM of which 3, miR-370, miR-26, miR-128 (fold changes are 9.3, 1.8, 1.7 respectively; all P < 0.05) were related to lipid metabolism. +genetics_GWAS 30818878 hsa-mir-143 Lymphoma, Non-Hodgkin We identified three SNPs in MIR143 that are to be significantly associated with reduced risk of NHL: rs3733846 (odds ratio (OR) [95% confidence interval (CI)] = 0.54 [0.33 (-) 0.86], p = 0.010), rs41291957 (OR [95% CI] = 0.61 [0.39 (-) 0.94], p = 0.024), and rs17723799 (OR [95% CI] = 0.43 [0.26 (-) 0.71], p = 0.0009). Our study is the first to report a correlation between miRSNPs in MIR143 and a reduced risk of NHL in Caucasians, and it is supported by significant SNPs in high linkage disequilibrium (LD) in a large European NHL genome wide association study (GWAS) meta-analysis. +other 30818424 hsa-mir-199b Prostatic Neoplasms, Castration-Resistant OBJECTIVES: To identify oncogenes regulated by micro-ribonucleic acid, miR-199a/b-3p, in metastatic castration-resistant prostate cancer. +other 30818424 hsa-mir-199a Prostatic Neoplasms, Castration-Resistant OBJECTIVES: To identify oncogenes regulated by micro-ribonucleic acid, miR-199a/b-3p, in metastatic castration-resistant prostate cancer. +lncRNA target 30817902 hsa-mir-18a Breast Neoplasms Targeted regulation of Rell2 by microRNA-18a is implicated in the anti-metastatic effect of polyphyllin VI in breast cancer cells. The current work thus demonstrates for the first time that targeted regulation of Rell2 by miR-18a is in part implicated in the anti-metastatic effect of PP-VI in breast cancer cells, providing novel pharmacological insights into the anti-cancer effect of PP-VI. +transcription factor target 30817728 hsa-mir-2355 Inflammation 5p negatively regulated ERFFI1 and prevented the effects of ERRFI1 on inhibiting NP cells proliferation and inflammation. +transcription factor target 30817728 hsa-mir-2355 Intervertebral Disc Degeneration 5p negatively regulated ERFFI1 and prevented the effects of ERRFI1 on inhibiting NP cells proliferation and inflammation. +circulation_biomarker_diagnosis_down 30817108 hsa-mir-132 Parkinson Disease Our data clearly demonstrated that the plasma miR-132 level in PD was significantly higher than those in HC (178%, p < 0.05) and NDC (188%, p < 0.001). +genetics_overexpression_promote 30816994 hsa-mir-145 recessive dystrophic epidermolysis bullosa 5p is overexpressed in RDEB skin fibroblasts (RDEBFs), where it plays a profibrotic role, as its inhibition reduces RDEBF fibrotic traits (contraction, proliferation and migration). +other 30816697 hsa-mir-27a hereditary diffuse gastric cancer Herein, we report the design of a nucleic acid circuit for gastric cancer-related microRNA-27a (miRNA-27a) detection based on dual toehold-mediated circular strand displacement amplification (CSDA). +genetics_overexpression_suppress 30816573 hsa-mir-497 Carcinoma, Non-Small-Cell Lung 5p overexpression inhibited NSCLC cell proliferation, migration and invasion, and induced cell apoptosis through inhibiting SOX5 gene expression. +lncRNA target 30816543 hsa-mir-146a Carcinoma, Non-Small-Cell Lung To perform further investigation of miR146a5p, the present study evaluated miR146a5p by targeting its downstream gene tumor collagenase stimulatory factor (TCSF) to influence cell viability, proliferation and apoptosis in NSCLC. +genetics_overexpression_suppress 30816534 hsa-mir-122 Prostatic Neoplasms In prostate carcinoma cells, miR122 overexpression inhibited the proliferation and the expression of ROCK2. +genetics_GWAS 30816526 hsa-mir-92a Colorectal Neoplasms DualLuciferase assays in human colorectal carcinoma (HCT116) and lung adenocarcinoma (A549) cells revealed downregulation of NF2 by miR92a3p via its wildtype 3'UTR, but not NF23'UTR with mutated miR92a3p MRE. +lncRNA target 30816512 hsa-mir-122 Stomach Neoplasms Also, suppression of miR1225p significantly reduced AFP levels and proliferation in AFPGC through an induction of apoptosis. +lncRNA target 30816505 hsa-mir-144 Colorectal Neoplasms Therefore, miR144 may have potential as a prognostic marker or therapeutic target for CRC. +other 30816481 hsa-mir-186 Migraine Disorders Previous works have screened the ACMassociated differentially expressed microRNAs (miRs), including miR1865p and miR4883p. +other 30816481 hsa-mir-488 Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative Previous works have screened the ACMassociated differentially expressed microRNAs (miRs), including miR1865p and miR4883p. +other 30816481 hsa-mir-488 Migraine Disorders Previous works have screened the ACMassociated differentially expressed microRNAs (miRs), including miR1865p and miR4883p. +other 30816481 hsa-mir-186 Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative Previous works have screened the ACMassociated differentially expressed microRNAs (miRs), including miR1865p and miR4883p. +genetics_overexpression_promote 30816475 hsa-mir-136 Breast Neoplasms In vitro silencing of circRNACER using small interfering RNA (siRNA) had inhibitory effects on MCF7 breast cancer cell proliferation and migration, and similar results were obtained following overexpression of microRNA (miR)136 in MCF7 cells by transfection with miR136 mimics. +lncRNA target 30816471 hsa-mir-101 Colonic Neoplasms The present results suggested that miR101 may serve a role in colon cancer by directly targeting CREB1. +other 30816460 hsa-mir-506 Uveal melanoma The majority of common miRNAs belonged to the miR506514 cluster, known to be involved in UM development. +other 30816460 hsa-mir-514 Uveal melanoma The majority of common miRNAs belonged to the miR506514 cluster, known to be involved in UM development. +genetics_overexpression_promote 30816452 hsa-mir-466 Osteosarcoma Furthermore, IRS1 overexpression was able to partially reverse the suppressive effects of miR466 overexpression in OS cells. +genetics_knock down_promote 30816451 hsa-mir-494 Spinal Cord Injuries Administration of a SIRT1 agonist reduced the effects of miR494 overexpression on cell apoptosis in an SCI model, whereas treatment with a p53 agonist reduced the effects of miR494 knockdown on cell apoptosis in an SCI model. +genetics_overexpression_promote 30816445 hsa-mir-106b Esophageal Squamous Cell Carcinoma Furthermore, the results demonstrated that miR106b3p overexpression promoted migration, invasion and epithelialmesenchymal transition (EMT) of ESCC cells. +other 30816442 hsa-mir-124 Osteosarcoma The roles of hsamiR124 and hsamiR7 in osteosarcoma recurrence were also validated using GSE79181. Thus, in conclusions, the three lncRNAs (LINC00028, LINC00323 and SNHG1), two miRNAs (hsamiR124 and hsamiR7) and three mRNAs (RAP1B, ATF2, and PPM1B) were associated with osteosarcoma recurrence. +other 30816442 hsa-mir-7 Osteosarcoma The roles of hsamiR124 and hsamiR7 in osteosarcoma recurrence were also validated using GSE79181. Thus, in conclusions, the three lncRNAs (LINC00028, LINC00323 and SNHG1), two miRNAs (hsamiR124 and hsamiR7) and three mRNAs (RAP1B, ATF2, and PPM1B) were associated with osteosarcoma recurrence. +genetics_knock down_promote 30816441 hsa-let-7d Ovarian Neoplasms The let7d5p level was detected in OC tissues and adjacent normal tissues, followed by detection in OC cell lines SKOV3, A2780, OVCAR3 and CaOV3, and human normal ovarian epithelial cell line (IOSE80), in order to select the OC cell line for the following experiments. +lncRNA target 30816435 hsa-mir-497 Breast Neoplasms Moreover, mechanical experiments demonstrated that lncRNA CASC9 positively regulated checkpoint kinase 1 (CHK1) by competitively binding to the miR195/497 cluster in BC cells. Taken together, the results of this study indicate that lncRNA CASC9 plays an oncogenic role in BC through sponging the miR195/497 cluster, and that lncRNA CASC9 may be used as a novel therapeutic target and as a potential diagnostic marker for BC. +lncRNA target 30816435 hsa-mir-195 Breast Neoplasms Moreover, mechanical experiments demonstrated that lncRNA CASC9 positively regulated checkpoint kinase 1 (CHK1) by competitively binding to the miR195/497 cluster in BC cells. Taken together, the results of this study indicate that lncRNA CASC9 plays an oncogenic role in BC through sponging the miR195/497 cluster, and that lncRNA CASC9 may be used as a novel therapeutic target and as a potential diagnostic marker for BC. +lncRNA target 30816432 hsa-mir-99a bladder urothelial carcinoma Identifying novel genes targeted by tumorsuppressive miR99a3p in sunitinibresistant RCC cells may improve our understanding of intrinsic or acquired resistance and facilitate the development of novel therapeutic strategies. +genetics_overexpression_promote 30816202 hsa-mir-494 Carcinoma, Non-Small-Cell Lung In this study, we found that overexpression of miR-494 promoted the proliferation and colony formation of NSCLC cells and reduced their sensitivity to cisplatin-induced apoptosis. +other 30815865 hsa-mir-675 Diabetic Nephropathies CONCLUSION: In summary, the above results indicate the presence of a negative feedback loop in the pathological mechanism of DN, where H19 downregulates the expression of VDR by upregulating the expression of miR-675, whereas reduced VDR expression subsequently reduced the expression of EGR1. +lncRNA target 30815771 hsa-mir-23b Carcinoma, Hepatocellular CONCLUSIONS: Our findings suggest that inhibition of miR-23b could be used as a novel approach in inhibition of HCC proliferation. +other 30814823 hsa-mir-212 Alzheimer Disease labiosiformis extract on expression of miR-132 and miR-212 and ROS level, this herb could be used as a suitable candidate for future studies on neurodegenerative diseases including AD. +other 30814823 hsa-mir-132 Alzheimer Disease labiosiformis extract on expression of miR-132 and miR-212 and ROS level, this herb could be used as a suitable candidate for future studies on neurodegenerative diseases including AD. +transcription factor target 30814512 hsa-mir-215 Thyroid Cancer, Papillary Moreover, we found that miR-215 suppressed PTC metastasis by modulating the epithelial-mesenchymal transition via the AKT/GSK-3beta/Snail signaling. +other 30814073 hsa-mir-27a Ovarian Insufficiency, Premature RESULTS: Compared with the control group, XIAP expression was significantly lower, and miR-23a and miR-27a expression significantly higher in the POF group. +other 30814073 hsa-mir-23a Ovarian Insufficiency, Premature RESULTS: Compared with the control group, XIAP expression was significantly lower, and miR-23a and miR-27a expression significantly higher in the POF group. +other 30813744 hsa-mir-21 Colonic Neoplasms METHODS: We used the synthetic oligonucleotide miR-21 and formalin-fixed, paraffin-embedded (FFPE) tissue sections from colon cancer samples ( n = 10). +genetics_knock down_promote 30813466 hsa-mir-29b-1 Squamous Cell Carcinoma of Head and Neck In OSCC cells exhibiting the EMT phenotype, knockdown of miR-29b +tissue_expression_up 30813413 hsa-mir-23a Developmental Disabilities Vitamin deficiency resulted in weaned pups (21 days) in growth retardation, delayed ossification, brain atrophy and cognitive deficits, along with unchanged brain level of let-7a and decreased expression of miR-34a and miR-23a. +tissue_expression_up 30813413 hsa-let-7a Developmental Disabilities Vitamin deficiency resulted in weaned pups (21 days) in growth retardation, delayed ossification, brain atrophy and cognitive deficits, along with unchanged brain level of let-7a and decreased expression of miR-34a and miR-23a. +tissue_expression_up 30813413 hsa-mir-34a Developmental Disabilities Vitamin deficiency resulted in weaned pups (21 days) in growth retardation, delayed ossification, brain atrophy and cognitive deficits, along with unchanged brain level of let-7a and decreased expression of miR-34a and miR-23a. +other 30813343 hsa-mir-144 lung squamous cell carcinoma Our previous study showed that both strands of pre-miR-144 acted as antitumor miRNAs and were involved in lung squamous cell carcinoma (LUSQ) pathogenesis. +lncRNA target 30813343 hsa-mir-451a lung squamous cell carcinoma Here, we aimed to investigate the functional significance of miR-451a and to identify its targeting of oncogenic genes in LUSQ cells. +circulation_biomarker_diagnosis_ns 30813134 hsa-mir-20a Schizophrenia Screening of schizophrenia associated miRNAs and the regulation of miR-320a-3p on integrin 1. An enzyme-linked immune sorbent assay demonstrated that the ITG 1 concentration increased significantly in the patients' serum, and the in vitro study confirmed that miR-320a-3p targeted the 3' UTR of ITG 1 mRNA and reduced its expression.Our results demonstrated that the regulatory effect of miR-320a-3p on its target ITG 1 might play an important role in schizophrenia pathogenesis, which could be a potential pathway for schizophrenia diagnosis and therapy. +lncRNA target 30811964 hsa-mir-21 Colorectal Neoplasms KEY FINDINGS: We found that curcumol effectively inhibited CRC cells from proliferating via the PTEN/PI3K/Akt pathways and reduced expression of miR-21 both in vitro and in vivo. +other 30811958 hsa-mir-144 Pulmonary Edema attenuated activation of inflammatory ROCK1/MLC pathway in vascular ECs is a promising therapeutic strategy to counter inflammatory lung injury. +lncRNA target 30811764 hsa-mir-153 Thyroid Cancer, Papillary Long non-coding RNA TTN-AS1 facilitates tumorigenesis of papillary thyroid cancer through modulating the miR +genetics_overexpression_suppress 30811684 hsa-mir-338 Carcinoma, Non-Small-Cell Lung Overexpression of miR +genetics_overexpression_promote 30811223 hsa-mir-29a Squamous Cell Carcinoma of Head and Neck Moreover, SOCS1 overexpression reverses the activity of SOCS1/STAT6 signals of macrophages and cell proliferation and invasion of OSCCs induced by miR-29a-3p overexpression. +genetics_GWAS 30811087 hsa-mir-496 Vascular Diseases Our findings reveal that, through epigenetic modification, ox-LDL can inhibit the normal expression of Hippo-YAP/ZAP pathway proteins via miR-496 expression and induce vascular endothelial cell dysfunction. +lncRNA target 30811042 hsa-mir-155 Liver Injury Collectively, these data highlight MCPIP1/miR-155/RORalpha axis as a novel modulation of inflammation in liver injury and potential therapeutic target for future research. +lncRNA target 30810894 hsa-mir-133a Digestive System Neoplasms MiR-133a is a tumor suppressor with prognostic and diagnostic values for digestive system cancers. +other 30810880 hsa-mir-4443 Ovarian Neoplasms RESULTS: The results showed that miR-4443 decreased in OC in metastatic and serous OC samples (0.154-fold, P < 0.0001). +other 30810880 hsa-mir-5195 Ovarian Neoplasms METHODS: Expression levels of miR-4443 and miR-5195 were evaluated in 45 ovarian tumor and 45 ovarian non-tumor tissue samples paraffin embedded using qPCR. +genetics_knock down_suppress 30810117 hsa-mir-454 Stomach Neoplasms CONCLUSIONS Our results suggest that lncRNA HOTAIR knockdown stimulates miR +other 30810094 hsa-mir-182 Ovarian Neoplasms, High-Grade Serous The objective of this study is to evaluate the relationship between discoidin domain receptor 2 (DDR2) and miR-182 expression with response to platinum-based chemotherapy and survival in women with high-grade serous ovarian cancer (HGSOC). In this relatively large cohort of women with HSGOC, higher DDR2 expression was associated with lower miR-182 levels and worse PFS, suggesting that these molecules may be associated with mechanisms of HGSOC progression. +genetics_overexpression_promote 30809930 hsa-mir-548d Squamous Cell Carcinoma of Head and Neck Furthermore, upregulated expression of miR-548d-3p could abrogate the effect of MEG3 overexpression on migration and apoptosis in OSCC cell lines. +lncRNA target 30809808 hsa-mir-211 Colorectal Neoplasms In our study, upregulated microRNA-211 (miR-211) and reduced FABP4 expression were detected in colorectal cancer (CRC) patients and CRC cells. Thus, the miR-211/FABP4/PPARgamma axis may be a novel target for CRC therapy. +circulation_biomarker_diagnosis_up 30809682 hsa-mir-125a Chronic Urticaria These results indicated that miR-125a-5p and CCL17 can serve as potential serum biomarkers for CSU. +circRNA target 30809316 hsa-mir-503 Hepatoblastoma 5p/IGF-PI3K-Akt axis regulates the proliferation, apoptosis and glutaminolysis of HB cells, implying that circHMGCS1 is a promising therapeutic target and prognostic marker for HB patients. +genetics_knock down_promote 30809286 hsa-mir-454 Breast Neoplasms 3p was amplified and overexpressed in metastatic breast cancer, and both were correlated with overall and relapse-free survival in breast cancer patients. +genetics_GWAS 30808975 hsa-mir-1205 Prostatic Neoplasms, Castration-Resistant Thus, by targeting EGLN3, miR-1205 has an oncogenic role and may contribute to the genetic risk of castration-resistant prostate cancer. +lncRNA target 30808969 hsa-mir-165 Dehydration In this study, we investigated the interplay and regulatory circuit between miR160 and miR165/166 and its effect on leaf development and drought tolerance in Arabidopsis using Short Tandem Target Mimic (STTM). Our results also suggested that miR160-directed regulation of auxin response factors (ARFs) contribute to leaf development via auxin signaling genes, whereas miR165/166- mediated HD-ZIP IIIs regulation confers drought tolerance through ABA signaling. +lncRNA target 30808969 hsa-mir-160 Dehydration In this study, we investigated the interplay and regulatory circuit between miR160 and miR165/166 and its effect on leaf development and drought tolerance in Arabidopsis using Short Tandem Target Mimic (STTM). Our results also suggested that miR160-directed regulation of auxin response factors (ARFs) contribute to leaf development via auxin signaling genes, whereas miR165/166- mediated HD-ZIP IIIs regulation confers drought tolerance through ABA signaling. +circulation_biomarker_diagnosis_ns 30808829 hsa-mir-192 Glomerulonephritis, IGA IgA nephropathy patients with higher serum miR-192 are less likely to have renal function decline over the course of 2 years. +lncRNA target 30808676 hsa-mir-644a Prostatic Neoplasms, Castration-Resistant These data demonstrate miR-644a mediated fine-tuning of oncogenesis, stimulating pathways and resultant potentiation of enzalutamide therapy in CRPC patients. SIGNIFICANCE: This study demonstrates that miR-644a therapeutically influences the CRPC tumor microenvironment by suppressing androgen signaling and additional genes involved in metabolism, proliferation, Warburg effect, and EMT, to potentiate the enzalutamide therapy.Graphical Abstract: http://cancerres.aacrjournals.org/content/canres/7 +genetics_knock down_suppress 30808545 hsa-mir-26a Anxiety Disorders In contrast, the transgenic murine model with miR-26a-2 knockdown in serotonergic neurons displayed increased anxious behavior and weakened antidepressant response. +genetics_knock down_suppress 30808545 hsa-mir-26a-2 Anxiety Disorders In contrast, the transgenic murine model with miR-26a-2 knockdown in serotonergic neurons displayed increased anxious behavior and weakened antidepressant response. +genetics_knock down_promote 30808147 hsa-mir-203 Laryngeal Neoplasms Result: microRNA-203 was lowly expressed in laryngeal cancer tissues and cell lines.Knockdown of microRNA-203 in Hep-2 cells can promote the invasiveness and inhibit apoptosis of laryngeal cancer cells. +circulation_biomarker_diagnosis_up 30807970 hsa-let-7d Attention Deficit Disorder with Hyperactivity These results suggest that serum miRNA-let-7d may serve as a potential diagnostic and therapeutic biomarker for children with ADHD. +other 30807841 hsa-mir-155 Spinal Cord Injuries Taken together, our data suggest an important role for IL-10/miR-155 pathway in regulating NOX2-mediated SCI-dysfunction. +other 30807603 hsa-mir-20a Colorectal Neoplasms We demonstrated a new possible pathway for CRC metastasis: miR5p/F9, miR20a/MMP2, CTSK, MMP3, and miR449a/P2RY14. +other 30807603 hsa-mir-576 Colorectal Neoplasms We demonstrated a new possible pathway for CRC metastasis: miR5p/F9, miR20a/MMP2, CTSK, MMP3, and miR449a/P2RY14. +transcription factor target 30807260 hsa-mir-124 Breast Neoplasms 3p and ABCC4 in breast cancer cells and to determine if duel targeting increased their sensitivity to chemotherapeutic drugs, in vitro. +transcription factor target 30807203 hsa-mir-204 Carcinoma, Hepatocellular Based on these results, we identified miR-204 as a tumor suppressor by inhibiting NUAK1 expression in liver cancer, indicating both miR-204 and NUAK1 may act as promising targets for liver cancer therapy. +other 30806889 hsa-mir-195 Glioma Downregulation of miR-195 was associated with poor prognosis in human glioma. +lncRNA target 30806335 hsa-mir-148a Breast Neoplasms OBJECTIVE: The aim of this study was to evaluate the role of melatonin and the tumor suppressor miR- 148a-3p on angiogenesis of breast cancer. +lncRNA target 30805988 hsa-mir-424 Liver Neoplasms Taken together, these results suggested that upregulated DLX6-AS1 promoted cell proliferation, migration, and invasion of HCC through increasing expression of WEE1 via targeting miR5p. +genetics_overexpression_promote 30805938 hsa-mir-449b Reperfusion Injury, Hepatic Ischemia In an in vivo rat model of hepatic I/R injury, overexpression of miR-449b-5p significantly decreased alanine aminotransferase and aspartate aminotransferase and inhibited the HMGB1/NF-kappaB pathway. +lncRNA target 30805592 hsa-mir-206 Carcinoma, Hepatocellular Furthermore, we identified that miR-206 targets the 3'-UTR of the cMET gene for silencing, and restoration of cMET expression reversed the inhibitory effect of miR-206 on HCC. +lncRNA target 30805585 hsa-mir-205 Stomach Neoplasms Meanwhile, large-scale genes of GCPR module were found to be targeted by miR-205, including two hub genes SORBS1 and LPAR1. In brief, through multiple analytical methods, we found that miR-205 and the GCPR module play critical roles in GC progression. +transcription factor target 30805558 hsa-mir-1236 Lung Neoplasms 3p could reverse DDP resistance by modulation of TPT1 gene and inhibition of Pim-3 signaling pathway in lung cancer cells. +other 30805015 hsa-mir-25 Carcinoma, Hepatocellular 3p was obviously down-regulated in HBV-HCC. +genetics_overexpression_promote 30804710 hsa-mir-92a Osteosarcoma Meanwhile, overexpression of miR-92a promoted proliferation, invasion and migration of OS cells in vitro as well as promoted growth and metastasis of OS cells in vivo. +transcription factor target 30804458 hsa-mir-6867 Hepatitis B Further studies revealed that ZNF382 was a target of miR-6867, and HBx promoted the translation of ZNF382 during HBV chronic infection through Erk-mediated miR-6867 inhibition. +transcription factor target 30804325 hsa-mir-4284 ankylosing spondylitis 1 Our findings indicate that ASMSCs exhibit a stronger capacity to inhibit osteoclastogenesis than HDMSCs through the miR-4284/CXCL5 axis, which provide a new perspective on the mechanism of pathologic osteogenesis in AS. +transcription factor target 30803553 hsa-mir-9 Colorectal Neoplasms We conclude that miR-9 inhibits CRC cell proliferation, migration, and invasion by directly targeting ANO1, and miR-9/ANO1 could be a potential therapeutic target for CRC. +circulation_biomarker_diagnosis_up 30803440 hsa-mir-21 Diabetes Mellitus Circulating microRNA-21 is an early predictor of ROS-mediated damage in subjects with high risk of developing diabetes and in drug-nave T2D. The aim of the present study was to evaluate microRNA-21 as a potential biomarker for the risk of developing diabetes in adults with IGT and to investigate its downstream effects as the generation of reactive oxygen species (ROS), the induction of manganese-superoxide dismutase-2 (SOD2), and the circulating levels of 4-HNE (4-hydroxynonenal). +circulation_biomarker_diagnosis_up 30803440 hsa-mir-21 Diabetes Mellitus, Type 2 Circulating microRNA-21 is an early predictor of ROS-mediated damage in subjects with high risk of developing diabetes and in drug-nave T2D. The aim of the present study was to evaluate microRNA-21 as a potential biomarker for the risk of developing diabetes in adults with IGT and to investigate its downstream effects as the generation of reactive oxygen species (ROS), the induction of manganese-superoxide dismutase-2 (SOD2), and the circulating levels of 4-HNE (4-hydroxynonenal). +lncRNA target 30803373 hsa-mir-132 Carcinoma, Pancreatic Ductal Bioinformatic analysis revealed that microRNA-132 may exert its effects on pancreatic ductal adenocarcinoma through downregulating mitogen-activated protein kinase 3 and nuclear transcription factor Y subunit alpha. +lncRNA target 30803283 hsa-mir-590 Osteoporosis 5p may represent a potential target for the treatment of diabetic osteoporosis. +circulation_biomarker_diagnosis_up 30803129 hsa-mir-204 Breast Neoplasms Our findings describe a relationship of the plasma levels of H19/miR-675 and NEAT1/miR-204 in the different BC subtypes; in addition, they reveal an interplay between these lncRNAs and miRNAs in the regulatory network in MCF-7 cells, which should also be considered in the search for new diagnostic and therapeutic markers. +circulation_biomarker_diagnosis_up 30803129 hsa-mir-675 Breast Neoplasms Our findings describe a relationship of the plasma levels of H19/miR-675 and NEAT1/miR-204 in the different BC subtypes; in addition, they reveal an interplay between these lncRNAs and miRNAs in the regulatory network in MCF-7 cells, which should also be considered in the search for new diagnostic and therapeutic markers. +circulation_biomarker_diagnosis_ns 30802839 hsa-mir-20a Cognition Disorders CONCLUSION: Low serum levels of miR-20a, -27a, and -103a are independently associated with cognitive impairment. +genetics_overexpression_promote 30802686 hsa-mir-21 Glioblastoma Here, we developed nanoparticles loaded with agents that inhibit miR-21, an oncogenic microRNA (miRNA) that is strongly overexpressed in GBM compared to normal brain tissue. +transcription factor target 30802676 hsa-mir-128 Inflammation It revealed that miR-128 specifically blocked the further development of inflammation through MyD88 down-regulation. +genetics_overexpression_promote 30802541 hsa-mir-451 Colonic Neoplasms RESULTS: Overexpression of miR-451 in colon cancer cells led to reduced cell proliferation, increased apoptosis and decrease accumulation of the cells at the G0/G1 phase of the cell cycle. +genetics_GWAS 30802538 hsa-mir-499 Coronary Disease This meta-analysis aimed to further investigate the possible association between miR-499 rs3746444 polymorphism and CHD risk. +lncRNA target 30802192 hsa-mir-29b Myocardial Infarction CONCLUSION: MiR-29b inhibited myocardial fibrosis and cardiac hypertrophy by activating the Notch signaling pathway and protected myocardium against myocardial infarction. +other 30802029 hsa-mir-122 Carcinoma, Hepatocellular The strategy developed herein is thus a highly promising platform for an effective codelivery of miRNA-122 and 5-Fu with facile fabrication and great potential for the clinical translation toward HCC synergistic therapy. +lncRNA target 30801976 hsa-mir-497 Alzheimer Disease 5p, promoted the expression of ZO-1, occludin and claudin-5, and ultimately alleviated BBB permeability in AD microenvironment. +genetics_knock down_promote 30801960 hsa-mir-383 Carcinoma, Hepatocellular Overexpression of miR-383 promoted HCC cells to undergo Dox-induced cytotoxicity and apoptosis, whereas miR-383 knockdown had the opposite effects. +other 30801535 hsa-mir-146a Primary Graft Dysfunction Additional work will need to be done to understand the role of MIR146A in the risk of AR in kidney allograft recipients. +other 30800239 hsa-mir-326 Leukemia Differential expression of hsa-miR-326 was detected between leukemic and non-leukemic samples from archived slides or fresh frozen bone marrows. +genetics_GWAS 30799952 hsa-mir-204 Thyroid Cancer, Papillary Novel target genes and putative mechanisms of miR-204 in PTC need to be further validated. +circulation_biomarker_diagnosis_down 30799804 hsa-mir-145 Carcinoma, Ovarian Epithelial In this study, we identified the clinicopathological hallmarks altered owing to the downexpression of serum miR-145 in EOC. CONCLUSION: Our results propose that miR-145 down-regulation might be a possible touchstone for disease progression and be identified as a diagnostic marker and predict disease outcome in EOC patients. +genetics_GWAS 30799315 hsa-mir-155 Hyperparathyroidism 2 Genetic analysis was performed to evaluate germinal and somatic CDC73 gene mutation as well as real-time qRT-PCR to quantify CDC73 mRNA, miR-155 and miR-664 expression levels. No CDC73 LOH was found in PC tissue, nor any differences in expression levels for CDC73 gene, miR-155 and miR-664 between PC and parathyroid adenoma control tissues. +genetics_GWAS 30799315 hsa-mir-664 Parathyroid Neoplasms Genetic analysis was performed to evaluate germinal and somatic CDC73 gene mutation as well as real-time qRT-PCR to quantify CDC73 mRNA, miR-155 and miR-664 expression levels. No CDC73 LOH was found in PC tissue, nor any differences in expression levels for CDC73 gene, miR-155 and miR-664 between PC and parathyroid adenoma control tissues. +genetics_GWAS 30799315 hsa-mir-155 Parathyroid Neoplasms Genetic analysis was performed to evaluate germinal and somatic CDC73 gene mutation as well as real-time qRT-PCR to quantify CDC73 mRNA, miR-155 and miR-664 expression levels. No CDC73 LOH was found in PC tissue, nor any differences in expression levels for CDC73 gene, miR-155 and miR-664 between PC and parathyroid adenoma control tissues. +genetics_GWAS 30799315 hsa-mir-664 Hyperparathyroidism 2 Genetic analysis was performed to evaluate germinal and somatic CDC73 gene mutation as well as real-time qRT-PCR to quantify CDC73 mRNA, miR-155 and miR-664 expression levels. No CDC73 LOH was found in PC tissue, nor any differences in expression levels for CDC73 gene, miR-155 and miR-664 between PC and parathyroid adenoma control tissues. +lncRNA target 30799283 hsa-mir-183 Leukemia, Myeloid, Acute 5p/Erbin signaling pathway might represent a novel prognostic biomarker or therapeutic target for treatment of AML. +epigenetics 30798618 hsa-mir-24-1 Heart Failure Subsequent gene/ncRNA expression analysis was assessed using quantitative reverse transcription polymerase chain reaction and revealed 6 genes: 4 hypermethylated ( HEY2, MSR1, MYOM3, and COX17), 2 hypomethylated ( CTGF and MMP2); and 2 microRNA: 1 hypermethylated (miR1), 1 hypomethylated (miR-155) with significantly upregulated or downregulated expression levels consistent with the direction of methylation in the particular HF subgroup. +genetics_overexpression_promote 30798328 hsa-mir-483 Wilms Tumor Overexpression of miR +lncRNA target 30798122 hsa-mir-10a Reperfusion Injury, Cerebral Ischemia Our present study indicated that TAB possessed neuroprotective property against ODG/R and I/R injury by suppressing miR-10a expression, activating PI3K/Akt/mTOR signaling pathway, thereby reducing mitochondrial-mediated apoptosis, which provided a new insight for interpreting the underlying mechanisms of TAB' neuroprotective effect and a candidate agent to treat cerebral I/R injury. +genetics_overexpression_suppress 30798120 hsa-mir-210 Squamous Cell Carcinoma of Head and Neck 3p overexpression contributed to the acceleration of OSCC growth. +genetics_GWAS 30798118 hsa-mir-451 Cardiomegaly This study explored the function of genistein from the epigenetic level, suggesting that miR-451 may play a significant role in the genistein-assisted amelioration of isoproterenol-induced cardiac hypertrophy both in vitro and in vivo. +genetics_overexpression_promote 30798028 hsa-mir-26a Fatty Liver Furthermore, overexpression of miR-26a abolished steatosis in HepG2 cells treated with PM(2.5) liposoluble extracts by suppressing CD36. +other 30797712 hsa-mir-93 Colorectal Neoplasms BACKGROUND: The low expression of miR93/25 (members of miR-106b~25 cluster) promoted the invasion and metastasis of colon cancer cells, which predicted poor survival. +other 30797712 hsa-mir-25 Colorectal Neoplasms BACKGROUND: The low expression of miR93/25 (members of miR-106b~25 cluster) promoted the invasion and metastasis of colon cancer cells, which predicted poor survival. +lncRNA target 30797712 hsa-mir-106b Colorectal Neoplasms INTERPRETATION: miR-106b-5p served as a suppressor in combination with MALAT1/miR-106b-5p/SLAIN2, which might be a group of potential prognostic biomarkers in the prognosis of CRC. +genetics_knock down_promote 30797154 hsa-mir-151a Osteosarcoma Finally, rescue experiments confirmed that RAB22 A overexpression could reverse the promotive effects of miRNA-151a-3p knockdown on invasive and migratory potentials of osteosarcoma cells. +other 30797151 hsa-mir-378 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Our research demonstrated the oncogenic nature of miR-378 in CML, and might contribute to the progress of CML. +circulation_biomarker_diagnosis_up 30797148 hsa-mir-101 Colorectal Neoplasms In conclusion, we have verified that circVAPA is up-regulated in CRC patients' tissues and plasma, and exerts oncogenic properties by sponging miR-101 in CRC. +lncRNA target 30797016 hsa-mir-145 Intervertebral Disc Degeneration ADAM17, which is expressed in degenerative discs, is the target of miR-145. +other 30797016 hsa-mir-145 Osteoarthritis miR-145 is an important microRNA related to degenerative diseases such as osteoarthritis. +other 30797016 hsa-mir-145 Intervertebral disc disease Here, the effect of miR-145 in IDD was elucidated. miR-145 is thus a potential therapeutic microRNA for IDD. +other 30797016 hsa-mir-145 Neurodegenerative Diseases miR-145 is an important microRNA related to degenerative diseases such as osteoarthritis. +circRNA target 30796202 hsa-mir-139 Thyroid Cancer, Papillary 5p/LMO4 axis could be targeted as a potential treatment strategy for PTC. +genetics_knock down_promote 30795814 hsa-mir-9 Glioma Gain- and loss-of-function assays were applied to identify the effects of miR-9 on glioma cells and HUVECs in vitro and in vivo. +circRNA target 30795787 hsa-mir-421 Carcinoma, Hepatocellular Moreover, circSETD3 inhibits the growth of HCC partly through the circSETD3/miR-421/MAPK14 pathway. +other 30794914 hsa-mir-365 Carcinoma, Hepatocellular Moreover, rescue assays indicated that the effect of PVT1 on autophagy of HCC cells were dependent on miR-365. +lncRNA target 30794866 hsa-mir-155 Cardiomegaly Taken together, CYTOR might play a protective role in cardiac hypertrophy through miR-155 and downstream IKKi and NF-kappaB signaling, most possibly through serving as a ceRNA for miR-155 to counteract miRmediated repression of IKBKE. +other 30794820 hsa-mir-9 Ovarian Diseases However, whether miR-9 affects ovarian dysfunction of PCOS and the related mechanisms are still unclear. +circulation_biomarker_diagnosis_ns 30794820 hsa-mir-9 Polycystic Ovary Syndrome We found increased miR-9 and decreased VDR in the blood and isolated ovarian GCs of women with PCOS compared with the controls. +lncRNA target 30794031 hsa-mir-217 Colorectal Neoplasms In brief, our research findings revealed that ZEB1-induced upregulation of KCNQ1OT1 improved the proliferation, migration and EMT formation of CRC cells via regulation of miR-217/ZEB1 axis. +lncRNA target 30793707 hsa-mir-449b Osteosarcoma Mechanistic investigations demonstrated that MALAT1, as a competing endogenous RNA (ceRNA), regulated osteosarcoma proliferation and metastasis through competitively binding to miR-34a/c-5p and miR-449a/b. +lncRNA target 30793707 hsa-mir-34c Osteosarcoma Mechanistic investigations demonstrated that MALAT1, as a competing endogenous RNA (ceRNA), regulated osteosarcoma proliferation and metastasis through competitively binding to miR-34a/c-5p and miR-449a/b. +lncRNA target 30793707 hsa-mir-449a Osteosarcoma Mechanistic investigations demonstrated that MALAT1, as a competing endogenous RNA (ceRNA), regulated osteosarcoma proliferation and metastasis through competitively binding to miR-34a/c-5p and miR-449a/b. +lncRNA target 30793707 hsa-mir-34a Osteosarcoma Mechanistic investigations demonstrated that MALAT1, as a competing endogenous RNA (ceRNA), regulated osteosarcoma proliferation and metastasis through competitively binding to miR-34a/c-5p and miR-449a/b. +other 30793488 hsa-mir-186 Alzheimer Disease In addition, we also observed aberrant expression of DDX43/H19/miR-186 axis (increased DDX43/H19 and decreased miR-186) in K562/DAC cells. Taken together, we successfully established DAC-resistant K562 cell line which can serve as a good model for investigating DAC resistance mechanisms, and DDX43/H19/miR-186 may be involved in DAC resistance in K562. +transcription factor target 30793480 hsa-mir-34a Diabetes Mellitus Hence, the present study has uncovered a P53/miR-34a/SIRT1 pathway that leads to endothelial dysfunction, suggesting that P53/miR-34a inhibition could be a viable strategy in the management of diabetic macrovascular diseases. +lncRNA target 30793479 hsa-mir-19a Stomach Neoplasms Dual-luciferase reporter assay confirmed the direct interaction between SLC25A5-AS1 and miR-19a-3p, rescue experiment showed that co-transfection miR-19a-3p mimics and pcDNA-SLC25A5-AS1 could partially restore the ability of GC cell proliferation and the inhibition of cell apoptosis. The mechanism analyses further found that SLC25A5-AS1 might act as a competing endogenous RNAs (ceRNA), which was involved in the derepression of PTEN expression, a target gene of miR-19a-3p, and regulate malignant phenotype via PI3K/AKT signalling pathway in GC. +other 30793356 hsa-let-7b Uterine Cervical Neoplasms Competing long noncoding RNA 2 (lncRNA 2) for microRNA let-7b (CERNA2) has emerged as an important regulator of tumorigenesis and cancer progression but the clinical value and regulatory function of CERNA2 is yet to be investigated in cervical carcinoma. +lncRNA target 30792687 hsa-mir-34a Alzheimer Disease An up-regulated microRNA-34a, already implicated in age-related inflammatory-neurodegeneration-appears to down-regulate key mRNA targets involved in synaptogenesis and synaptic-structure, distinguishing neuronal deficits associated with AD neuropathology. This paper reports on recent studies of a miRNA-34a-up-regulation coupled to SHANK3 mRNA down-regulation in sporadic AD superior-temporal lobe compared to age-matched controls. +other 30792263 hsa-mir-182 Dilated Cardiomyopathy 5p may potentially show diagnostic value. +other 30792210 hsa-mir-127 D-bifunctional protein deficiency Differential expression analysis of micro-RNA in the physiological stem cell-to-multi-potent progenitor transition and in Pbx1-deficient stem cells compared to control stem cells revealed miR3p as the most differentially expressed. +lncRNA target 30792210 hsa-mir-127 Bone Marrow Diseases Inhibition of miR3p function in Lineage-negative cells, achieved through a lentiviral-sponge vector, led to severe stem cell depletion, as assessed with serial transplantation assays. +genetics_overexpression_suppress 30792210 hsa-mir-127 Lymphopenia 3p overexpression in Lineage-negative cells did not alter stem cell pool size, but gave rise to lymphopenia, likely due to lack of miR +other 30792093 hsa-mir-3 Hernias, Diaphragmatic, Congenital miR-33 and MKI67 were increased, and Lgl1 was decreased in CDH+TO. +lncRNA target 30791979 hsa-mir-100 Carcinoma, Non-Small-Cell Lung The outcome of the combined approaches uncovered miR5p to confer resistance to Crizotinib and Lorlatinib in EML4-ALK NSCLC cells and to be a potential therapeutic target in drug resistance. +other 30791797 hsa-mir-196a Osteosarcoma In conclusion, lncRNA SNHG3 promoted cell growth by sponging miR-196a-5p and indicated a poor prognosis in OS patients. +other 30791468 hsa-mir-17 Colorectal Neoplasms A statistically significant inverse correlation between KCNMA1 expression and mir5p levels was observed in patients with CRC. +epigenetics 30791232 hsa-mir-487b Colorectal Neoplasms Collectively, miR-487b is regulated by DNA methylation and it functions as a tumor suppressor in CRC mainly through targeting MYC, SUZ12, and KRAS. +genetics_overexpression_promote 30790680 hsa-mir-215 Colonic Neoplasms Through stable overexpression of miR-215, followed by a set of functional in vitro and in vivo investigations, miR-215 was pinpointed as a negative feedback regulator, working against the TIC-promoting effects of hypoxia. +lncRNA target 30790638 hsa-mir-941 Uterine Cervical Neoplasms Our observations elucidated the carcinogenic role of lncRNA RP11-552M11.4 in CC was mediated through miR-3941/ATF1 axis, giving a new insight into the effective target for the treatment and prognosis of cervical cancer. +lncRNA target 30790508 hsa-mir-486 Intervertebral Disc Degeneration 5p can inhibit inflammatory response, ECM degradation and apoptosis in NP cells by directly targeting FOXO1, which may contribute to the biological therapy of IDD. +other 30790283 hsa-mir-375 Craniosynostosis radial aplasia syndrome In human data, OGS samples showed increased expressions of ERalpha, p-PI3KCA(Tyr317) , and p-AKT (Ser473) proteins, followed by notably upregulated miR-375 content in comparison with that in OGS-free. Collectively, our current results elucidate that FN exerts effective therapeutic benefits against OGS, and the pharmacological mechanism may be related to promoting cell apoptosis by inactivating intracellular miR-375/ERalpha-PI3K/AKT cascaded pathway. +transcription factor target 30789953 hsa-mir-26 Primary Ovarian Insufficiency Specific miRNAs predicted to target stress axis transcripts decreased (miR-740) or increased (miR-26, miR-30d, miR-92a, miR-103) in eggs collected from FLX females at 5 months. +transcription factor target 30789953 hsa-mir-92a Primary Ovarian Insufficiency Specific miRNAs predicted to target stress axis transcripts decreased (miR-740) or increased (miR-26, miR-30d, miR-92a, miR-103) in eggs collected from FLX females at 5 months. Increased abundance of miRNA-30d and miRNA-92a persisted in eggs collected from FLX females at 9 months. +transcription factor target 30789953 hsa-mir-740 Primary Ovarian Insufficiency Specific miRNAs predicted to target stress axis transcripts decreased (miR-740) or increased (miR-26, miR-30d, miR-92a, miR-103) in eggs collected from FLX females at 5 months. +other 30789054 hsa-let-7c Asthma The aim of this study was to investigate the expression patterns of miRNA-let 7a, 7b, and 7c in bronchoalveolar lavage fluid in infants with asthma and airway foreign bodies. The increased expression of miRNA-let 7a, 7b, and 7c were associated with the asthma of infants. +other 30789054 hsa-let-7a Asthma The aim of this study was to investigate the expression patterns of miRNA-let 7a, 7b, and 7c in bronchoalveolar lavage fluid in infants with asthma and airway foreign bodies. The increased expression of miRNA-let 7a, 7b, and 7c were associated with the asthma of infants. +circulation_biomarker_diagnosis_up 30788936 hsa-mir-1 Coronary Disease CONCLUSIONS To predict the occurrence of ISR for CHD patients, the plasma miRNA-1 and miRNA-21 have a relatively high specificity and sensitivity, for CHD patients with DM, miRNA-21 may have a higher clinical value. +circulation_biomarker_diagnosis_up 30788936 hsa-mir-1 Diabetes Mellitus CONCLUSIONS To predict the occurrence of ISR for CHD patients, the plasma miRNA-1 and miRNA-21 have a relatively high specificity and sensitivity, for CHD patients with DM, miRNA-21 may have a higher clinical value. +circulation_biomarker_diagnosis_up 30788936 hsa-mir-1 Instent Restenosis CONCLUSIONS To predict the occurrence of ISR for CHD patients, the plasma miRNA-1 and miRNA-21 have a relatively high specificity and sensitivity, for CHD patients with DM, miRNA-21 may have a higher clinical value. +circulation_biomarker_diagnosis_up 30788936 hsa-mir-21 Diabetes Mellitus CONCLUSIONS To predict the occurrence of ISR for CHD patients, the plasma miRNA-1 and miRNA-21 have a relatively high specificity and sensitivity, for CHD patients with DM, miRNA-21 may have a higher clinical value. +circulation_biomarker_diagnosis_up 30788936 hsa-mir-21 Coronary Disease CONCLUSIONS To predict the occurrence of ISR for CHD patients, the plasma miRNA-1 and miRNA-21 have a relatively high specificity and sensitivity, for CHD patients with DM, miRNA-21 may have a higher clinical value. +circulation_biomarker_diagnosis_up 30788936 hsa-mir-21 Instent Restenosis CONCLUSIONS To predict the occurrence of ISR for CHD patients, the plasma miRNA-1 and miRNA-21 have a relatively high specificity and sensitivity, for CHD patients with DM, miRNA-21 may have a higher clinical value. +lncRNA target 30788382 hsa-mir-1 Carcinoma, Hepatocellular EVs engineered with antitumor miRNAs (miR-31 and miR-451a) successfully promoted apoptosis of the HepG2 hepatocellular carcinoma cell line, silencing target genes involved in anti-apoptotic pathways. +lncRNA target 30788382 hsa-mir-451a Carcinoma, Hepatocellular EVs engineered with antitumor miRNAs (miR-31 and miR-451a) successfully promoted apoptosis of the HepG2 hepatocellular carcinoma cell line, silencing target genes involved in anti-apoptotic pathways. +lncRNA target 30788003 hsa-mir-663a Carcinoma, Pancreatic Ductal Our study suggests that miR-663a expression may be a useful indicator of the potential for chemoresistance and provides a potential new therapeutic target to avert chemoresistance in PDAC. +lncRNA target 30788002 hsa-mir-34a Abortion, Spontaneous In short, the current study suggests SNHG7-1 plays as an important role in RSA progression targeted by miR-34a via Wnt/beta-catenin signaling pathway, providing a novel insight for the pathogenesis and underlying therapeutic target for RSA. +other 30787994 hsa-mir-145 Aortic Diseases In this study, we found significantly increased expression of phospho-Smad2/3 and phospho-ERK in AD tissues and downregulated expression of miR143 and miR145 in AD tissues. +other 30787994 hsa-mir-143 Aortic Diseases In this study, we found significantly increased expression of phospho-Smad2/3 and phospho-ERK in AD tissues and downregulated expression of miR143 and miR145 in AD tissues. +genetics_overexpression_promote 30787993 hsa-mir-365 Glioblastoma Overexpression of miR-365 suppressed glioblastoma cell proliferation and migration and epithelial-to-mesenchymal transition through inhibiting PAX6 expression. +genetics_overexpression_promote 30787987 hsa-mir-202 Thyroid Neoplasms Overexpression of miR +circulation_biomarker_diagnosis_up 30787934 hsa-mir-152 Lupus Nephritis Conclusion: miR-152 expression was tapered in LN tissue and miR-152 expression was inversely correlated with chronicity index (CI), serum creatinine and severity of proteinuria. +circulation_biomarker_diagnosis_up 30787377 hsa-mir-15a Down Syndrome Our study revealed that there are 6 miRNAs were upregulated (hsa-miR-15a, hsa-let-7d, hsa-miR-142, hsa-miR-23a, hsa-miR-199, hsa-miR-191) and 7 were downregulated (hsa-miR-1290, hsa-miR-1915, hsa-miR30e, hsa-miR-1260, hsa-miR-483, hsa-miR-548, hsa-miR-590) in plasma samples of women with foetal DS syndrome. +circulation_biomarker_diagnosis_up 30787377 hsa-let-7d Down Syndrome Our study revealed that there are 6 miRNAs were upregulated (hsa-miR-15a, hsa-let-7d, hsa-miR-142, hsa-miR-23a, hsa-miR-199, hsa-miR-191) and 7 were downregulated (hsa-miR-1290, hsa-miR-1915, hsa-miR30e, hsa-miR-1260, hsa-miR-483, hsa-miR-548, hsa-miR-590) in plasma samples of women with foetal DS syndrome. +circulation_biomarker_diagnosis_up 30787377 hsa-mir-1290 Down Syndrome Our study revealed that there are 6 miRNAs were upregulated (hsa-miR-15a, hsa-let-7d, hsa-miR-142, hsa-miR-23a, hsa-miR-199, hsa-miR-191) and 7 were downregulated (hsa-miR-1290, hsa-miR-1915, hsa-miR30e, hsa-miR-1260, hsa-miR-483, hsa-miR-548, hsa-miR-590) in plasma samples of women with foetal DS syndrome. +circulation_biomarker_diagnosis_up 30787377 hsa-mir-199 Down Syndrome Our study revealed that there are 6 miRNAs were upregulated (hsa-miR-15a, hsa-let-7d, hsa-miR-142, hsa-miR-23a, hsa-miR-199, hsa-miR-191) and 7 were downregulated (hsa-miR-1290, hsa-miR-1915, hsa-miR30e, hsa-miR-1260, hsa-miR-483, hsa-miR-548, hsa-miR-590) in plasma samples of women with foetal DS syndrome. +circulation_biomarker_diagnosis_up 30787377 hsa-mir-1915 Down Syndrome Our study revealed that there are 6 miRNAs were upregulated (hsa-miR-15a, hsa-let-7d, hsa-miR-142, hsa-miR-23a, hsa-miR-199, hsa-miR-191) and 7 were downregulated (hsa-miR-1290, hsa-miR-1915, hsa-miR30e, hsa-miR-1260, hsa-miR-483, hsa-miR-548, hsa-miR-590) in plasma samples of women with foetal DS syndrome. +circulation_biomarker_diagnosis_up 30787377 hsa-mir-191 Down Syndrome Our study revealed that there are 6 miRNAs were upregulated (hsa-miR-15a, hsa-let-7d, hsa-miR-142, hsa-miR-23a, hsa-miR-199, hsa-miR-191) and 7 were downregulated (hsa-miR-1290, hsa-miR-1915, hsa-miR30e, hsa-miR-1260, hsa-miR-483, hsa-miR-548, hsa-miR-590) in plasma samples of women with foetal DS syndrome. +circulation_biomarker_diagnosis_up 30787377 hsa-mir-1260 Down Syndrome Our study revealed that there are 6 miRNAs were upregulated (hsa-miR-15a, hsa-let-7d, hsa-miR-142, hsa-miR-23a, hsa-miR-199, hsa-miR-191) and 7 were downregulated (hsa-miR-1290, hsa-miR-1915, hsa-miR30e, hsa-miR-1260, hsa-miR-483, hsa-miR-548, hsa-miR-590) in plasma samples of women with foetal DS syndrome. +circulation_biomarker_diagnosis_up 30787377 hsa-mir-548 Down Syndrome Our study revealed that there are 6 miRNAs were upregulated (hsa-miR-15a, hsa-let-7d, hsa-miR-142, hsa-miR-23a, hsa-miR-199, hsa-miR-191) and 7 were downregulated (hsa-miR-1290, hsa-miR-1915, hsa-miR30e, hsa-miR-1260, hsa-miR-483, hsa-miR-548, hsa-miR-590) in plasma samples of women with foetal DS syndrome. +circulation_biomarker_diagnosis_up 30787377 hsa-mir-483 Down Syndrome Our study revealed that there are 6 miRNAs were upregulated (hsa-miR-15a, hsa-let-7d, hsa-miR-142, hsa-miR-23a, hsa-miR-199, hsa-miR-191) and 7 were downregulated (hsa-miR-1290, hsa-miR-1915, hsa-miR30e, hsa-miR-1260, hsa-miR-483, hsa-miR-548, hsa-miR-590) in plasma samples of women with foetal DS syndrome. +circulation_biomarker_diagnosis_up 30787377 hsa-mir-23a Down Syndrome Our study revealed that there are 6 miRNAs were upregulated (hsa-miR-15a, hsa-let-7d, hsa-miR-142, hsa-miR-23a, hsa-miR-199, hsa-miR-191) and 7 were downregulated (hsa-miR-1290, hsa-miR-1915, hsa-miR30e, hsa-miR-1260, hsa-miR-483, hsa-miR-548, hsa-miR-590) in plasma samples of women with foetal DS syndrome. +circulation_biomarker_diagnosis_up 30787377 hsa-mir-142 Down Syndrome Our study revealed that there are 6 miRNAs were upregulated (hsa-miR-15a, hsa-let-7d, hsa-miR-142, hsa-miR-23a, hsa-miR-199, hsa-miR-191) and 7 were downregulated (hsa-miR-1290, hsa-miR-1915, hsa-miR30e, hsa-miR-1260, hsa-miR-483, hsa-miR-548, hsa-miR-590) in plasma samples of women with foetal DS syndrome. +circulation_biomarker_diagnosis_ns 30787203 hsa-mir-15b Coronary Artery Disease Objective: Present study focused on the influence of lncRNA MALAT1 on coronary atherosclerotic heart disease (CAD) by regulating miR-15b-5p/MAPK1 and mTOR signaling pathway.Method: Differentially expressed genes and activated pathway were investigated through bioinformatics analysis. QRT-PCR was conducted to verify expression of MALAT1, miR-15b-5p and MAPK1 in CAD blood samples and endothelial progenitor cells (EPCs). +transcription factor target 30786928 hsa-mir-101 Carcinoma, Hepatocellular CONCLUSION: Lnc-PDZD7 promotes stemness properties and suppresses chemosensitivity though the miR-101/EZH2/ATOH8 pathway, providing new biomarkers for diagnosis and potential drug targets for HCC. +circulation_biomarker_diagnosis_ns 30786836 hsa-mir-210 Breast Neoplasms CONCLUSIONS: Plasma miR-200a and miR-210 could be effective biomarkers for the prediction of chemotherapy resistance in metastatic breast cancer patients. +circulation_biomarker_diagnosis_ns 30786836 hsa-mir-200a Breast Neoplasms CONCLUSIONS: Plasma miR-200a and miR-210 could be effective biomarkers for the prediction of chemotherapy resistance in metastatic breast cancer patients. +circulation_biomarker_diagnosis_up 30786164 hsa-mir-371a Testicular Germ Cell Tumor However, normal testis, semen, and serum of males with a disrupted testicular integrity without a TGCT may contain miR-371a-3p levels above threshold, of which the cellular origin is unknown. +other 30786164 hsa-mir-371a Neoplasms, Germ Cell and Embryonal CONCLUSIONS: The observation is important in the context of applying miR-371a-3p as molecular liquid biopsy biomarker for diagnosis and follow-up of patients with malignant (T)GCT. +circulation_biomarker_diagnosis_up 30786164 hsa-mir-371a Testicular Neoplasms BACKGROUND: The microRNA-371a-3p (miR-371a-3p) has been reported to be an informative liquid biopsy (serum and plasma) molecular biomarker for both diagnosis and follow-up of patients with a malignant (testicular) germ cell tumor ((T)GCT). +circulation_biomarker_diagnosis_up 30786164 hsa-mir-371a Testicular Diseases However, normal testis, semen, and serum of males with a disrupted testicular integrity without a TGCT may contain miR-371a-3p levels above threshold, of which the cellular origin is unknown. +epigenetics 30785991 hsa-mir-200a Cardiomyopathy dilated with woolly hair and keratoderma CONCLUSIONS: DNMT1-mediated DNA hypermethylation can enhance the process of CEWH by directly targeting miR-200a and CDKN2B. +genetics_knock down_promote 30785086 hsa-mir-125b Mouth Neoplasms Exogenous miR-125b expression in OSCC cells results in increased oxidative stress, increased drug sensitivity, and suppressor activity that is paralleled by the knockout of PRXL2A gene. +genetics_knock down_promote 30785065 hsa-mir-198 Thyroid Cancer, Papillary "circRAPGEF5 knockdown inhibited cell proliferation, migration, and invasion in vitro; and circRAPGEF5 silencing downregulated fibroblast growth factor receptor 1 (FGFR1) expression by ""sponging"" miR-198, suppressing the aggressive biological behaviors of PTC. circRAPGEF5 acts as a tumor promoter via a novel circRAPGEF5/miR-198/FGFR1 axis, providing a potential biomarker and therapeutic target for the management of PTC." +other 30784933 hsa-mir-153 Esophageal Squamous Cell Carcinoma 3p/FYN regulatory pathway in ESCC. +genetics_knock down_promote 30784927 hsa-mir-204 Glioma In conclusion, knockdown of HOXD-AS1 suppressed proliferation, migration and invasion and enhanced DDP sensitivity of glioma cells through sequestering miR-204, providing a promising therapeutic target for glioma patients. +genetics_knock down_suppress 30784922 hsa-mir-145 Sepsis Furthermore, TGFBR2 overexpression abrogated miR-145 overexpression-mediated attenuation on LPS-induced sepsis. +lncRNA target 30784759 hsa-mir-181a Abnormalities, Drug-Induced After microinjection of miR-181a-5p mimic and inhibitor, zebrafish malformation type and percentage were prominently increased such as distorted SIV vessels along with reduced venation and abnormal branches by ALP staining. Microinjection of miR-181a-5p mimics and inhibitors led to abnormal expressions (20-50%) of two key target genes (pax2a and vash2) by WISH, and increased malformation percentages (18-45%) by IOD analysis. +genetics_knock down_promote 30784343 hsa-mir-185 Atherosclerosis Knockdown of miR-185 facilitated the progression of AS through enhancing cell proliferation, migration and invasion via targeting STIM1. +lncRNA target 30784290 hsa-mir-363 Melanoma 3p is induced by HIF-2alpha to promote the stemness of melanoma cells via inhibiting p21. +transcription factor target 30784283 hsa-mir-375 Glioblastoma Therefore, we concluded that miR-375 inhibited the proliferation and invasion of GBM by regulating Wnt5a and might be a possible therapeutic agent for GBM. +genetics_knock down_promote 30784279 hsa-mir-885 Glioblastoma 3p antagonized the effects of HOXB-AS1 konckdown and promoted the proliferation and migration of glioblastoma. +genetics_overexpression_promote 30784214 hsa-mir-200a Prostatic Neoplasms In vitro studies showed that miR-200a overexpression in CRPC cells markedly suppressed cellular proliferation and facilitated apoptosis. +lncRNA target 30784065 hsa-mir-1470 Diabetic Retinopathy Additionally, mRNA of epidermal growth factor receptor (EGFR) was proved as the target of miR-1470 and EGFR targeting by miR-1470 initiated KCNQ1OT1 deficiency-induced apoptosis and promoted proliferation. +other 30783954 hsa-mir-365 Coronary Artery Disease 3p had the highest sensitivity (74.3% and 90.0%, respectively) and specificity (71.4% and 93.3%) for detecting HTPR compared with the five other miRNAs. +other 30783954 hsa-mir-339 Coronary Artery Disease 3p had the highest sensitivity (74.3% and 90.0%, respectively) and specificity (71.4% and 93.3%) for detecting HTPR compared with the five other miRNAs. +genetics_overexpression_suppress 30783484 hsa-mir-708 Osteosarcoma 5p was significantly downregulated in osteosarcoma tissues and cells, and its overexpression significantly inhibited cell viability, invasion and migration and induced apoptosis of SaOS-2 cells. +other 30783469 hsa-mir-223 Liver Cirrhosis hsa-miR5p, hsa-miR-223 and hsa-miR-29c-3p identified patients with cirrhosis with AUC=0.776, 0.617 and 0.619, respectively. +other 30783469 hsa-mir-381 Liver Cirrhosis 3p were negatively correlated with alanine aminotransferase, aspartate transaminase and HBV viral DNA load. +other 30783469 hsa-mir-122 Hepatitis B, Chronic hsa-miR5p, hsa-miR-223 and hsa-miR-29c-3p identified patients with cirrhosis with AUC=0.776, 0.617 and 0.619, respectively. +other 30783469 hsa-mir-381 Hepatitis B, Chronic 3p were negatively correlated with alanine aminotransferase, aspartate transaminase and HBV viral DNA load. +other 30783469 hsa-mir-122 Liver Cirrhosis hsa-miR5p, hsa-miR-223 and hsa-miR-29c-3p identified patients with cirrhosis with AUC=0.776, 0.617 and 0.619, respectively. +other 30783469 hsa-mir-29c Hepatitis B, Chronic hsa-miR5p, hsa-miR-223 and hsa-miR-29c-3p identified patients with cirrhosis with AUC=0.776, 0.617 and 0.619, respectively. +other 30783469 hsa-mir-223 Hepatitis B, Chronic hsa-miR5p, hsa-miR-223 and hsa-miR-29c-3p identified patients with cirrhosis with AUC=0.776, 0.617 and 0.619, respectively. +other 30783469 hsa-mir-29c Liver Cirrhosis hsa-miR5p, hsa-miR-223 and hsa-miR-29c-3p identified patients with cirrhosis with AUC=0.776, 0.617 and 0.619, respectively. +genetics_knock down_promote 30783468 hsa-mir-34a Spinal Cord Injuries Furthermore, miR-34a knockdown was demonstrated to aggravate inflammation, inhibit cell proliferation and enhance apoptosis in an in vitro model of SCI. +genetics_GWAS 30783467 hsa-mir-421 Ossification, Heterotopic The present study aimed to investigate the role of miR-421 and bone morphogenetic protein-2 (BMP-2) in the bone tissues and blood of elderly patients with humeral fractures and heterotopic ossification. +genetics_GWAS 30783467 hsa-mir-421 Humeral Fractures The present study aimed to investigate the role of miR-421 and bone morphogenetic protein-2 (BMP-2) in the bone tissues and blood of elderly patients with humeral fractures and heterotopic ossification. +genetics_overexpression_suppress 30783458 hsa-mir-761 Colorectal Neoplasms Collectively, the present study demonstrated that miR-761 overexpression could inhibit the proliferation and migration of CRC cell lines, partly at least, via directly targeting Rab3D. +other 30783454 hsa-mir-1273g Liver Cirrhosis Further prospective studies are required to validate the efficacy of miR-1273g-3p as a predictor of liver fibrosis. +other 30783454 hsa-mir-1273g Hepatitis C Further prospective studies are required to validate the efficacy of miR-1273g-3p as a predictor of liver fibrosis. +other 30783443 hsa-mir-203 Uterine Cervical Neoplasms The expression of miR-210, miR-29a, miR-203 and miR-125b in HeLa (HPV16/18+), SiHa (HPV16+), CaSki (HPV16+) and C33A (HPV-) cell lines was measured using quantitative polymerase chain reaction analysis. +other 30783443 hsa-mir-29a Uterine Cervical Neoplasms The expression of miR-210, miR-29a, miR-203 and miR-125b in HeLa (HPV16/18+), SiHa (HPV16+), CaSki (HPV16+) and C33A (HPV-) cell lines was measured using quantitative polymerase chain reaction analysis. +other 30783443 hsa-mir-210 Uterine Cervical Neoplasms The expression of miR-210, miR-29a, miR-203 and miR-125b in HeLa (HPV16/18+), SiHa (HPV16+), CaSki (HPV16+) and C33A (HPV-) cell lines was measured using quantitative polymerase chain reaction analysis. +other 30783443 hsa-mir-29 Uterine Cervical Neoplasms The expression of miR-210, miR-29a, miR-203 and miR-125b in HeLa (HPV16/18+), SiHa (HPV16+), CaSki (HPV16+) and C33A (HPV-) cell lines was measured using quantitative polymerase chain reaction analysis. +other 30783443 hsa-mir-125b Uterine Cervical Neoplasms The expression of miR-210, miR-29a, miR-203 and miR-125b in HeLa (HPV16/18+), SiHa (HPV16+), CaSki (HPV16+) and C33A (HPV-) cell lines was measured using quantitative polymerase chain reaction analysis. +circulation_biomarker_diagnosis_ns 30783441 hsa-mir-10a Essential Hypertension Reverse transcription-quantitative polymerase chain reaction analysis was performed to determine the expression levels of hsa_circ_0014243 and hsa-microRNA (miR)-10a-5p in a total of 178 blood samples collected from 89 healthy controls and 89 patients diagnosed with EH. +circulation_biomarker_diagnosis_down 30783439 hsa-mir-494 Shock, Septic 3p is downregulated in the peripheral blood of patients with septic shock and is negatively correlated with myocardial injury. +lncRNA target 30783438 hsa-mir-183 Pancreatic Carcinoma The present study aimed to elucidate the role of miR-183 in the proliferation, apoptosis, and chemosensitivity to 5-fluorouracil and gemcitabine of human PC cells and the associated mechanisms. These results indicate that downregulation of miR-183 can inhibit the growth of PC cells in vitro and in vivo, and increase cell sensitivity to 5-fluorouracil and gemcitabine through regulating the PTEN/PI3K/Akt signaling pathway. +transcription factor target 30783424 hsa-mir-196a Hypoxia-Ischemia, Brain Furthermore, miR-196a was indicated to directly target and inhibit high mobility group A1 expression, which indicated a potential role for miR-196a in ischemic brain injury. These findings suggested that miR-196a may be involved in regulating neuronal cell death, thus offering a novel target for the development of therapeutic agents against ischemic brain injury. +lncRNA target 30783419 hsa-mir-181b Cicatrix, Hypertrophic Furthermore, treatment with MEK inhibitor in HSFbs transfected with miR-181b-5p mimics partially inhibited miR-181b-5p-induced antiapoptotic effects. +circulation_biomarker_diagnosis_down 30783418 hsa-mir-378 Asthma To conclude, the present study demonstrated that miR-378 expression was elevated in the peripheral blood and lung tissues from children with asthma. +genetics_GWAS 30783203 hsa-mir-196a Breast Neoplasms Genetic variants and altered expression of MIR196A are associated with risk and progression of multiple cancers including breast cancer, however little is known about the regulation of the genes encoding this miRNA, nor the impact of variants therein. +other 30783190 hsa-mir-9 Head and Neck Neoplasms Genome-wide miRNA profiling reinforces the importance of miR-9 in human papillomavirus associated oral and oropharyngeal head and neck cancer. Our findings compared with literature data revealed extensive heterogeneity of miRNA deregulation with only several miRNAs consistently affected, and miR-9 being the most likely HPV related miRNA. +transcription factor target 30783079 hsa-mir-34a Prostatic Neoplasms Our discovery of a previously unidentified miR-34a/miR-7/JARID2 pathway controlling dihydroartemisinin effects on Axl expression and inhibition of cancer cell proliferation, migration, invasion, and tumor formation provides new molecular mechanistic insights into dihydroartemisinin anticancer effect on prostate cancer with potential therapeutic implications. +transcription factor target 30783079 hsa-mir-7 Prostatic Neoplasms Our discovery of a previously unidentified miR-34a/miR-7/JARID2 pathway controlling dihydroartemisinin effects on Axl expression and inhibition of cancer cell proliferation, migration, invasion, and tumor formation provides new molecular mechanistic insights into dihydroartemisinin anticancer effect on prostate cancer with potential therapeutic implications. +lncRNA target 30782261 hsa-mir-761 Colorectal Neoplasms We saw that HDAC1 was a direct target gene of miR-761 in CRC by bioinformatic and luciferase reporter analyses. +lncRNA target 30782246 hsa-mir-101 Heart Septal Defects, Ventricular Our study reveals that SNHG6 may contribute to VSD formation via negative regulation of miR-101 and activation of Wnt/beta-catenin pathway. +lncRNA target 30782188 hsa-mir-194 Carcinoma, Hepatocellular MCM3AP-AS1 exerted an oncogenic role in HCC via targeting miR +transcription factor target 30782177 hsa-mir-365 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: Our data indicate that targeting a novel miR +other 30782157 hsa-mir-107 Urinary Bladder Neoplasms Furthermore, the expression of cTFRC correlated with TFRC and negatively correlated with miR-107 both in BC cell lines and BC clinical samples. +transcription factor target 30782086 hsa-mir-125a Placenta Accreta We aimed to investigate the influence of miR-125a on ISIT cells in PAS disorders in 15 patients (self-paired trials) with placenta previa and PAS disorders. In conclusion, downregulation of MCL1-targeting miR-125a exerts an antiapoptotic effect on ISIT cells in PAS disorders. +other 30782069 hsa-mir-1246 cone-rod dystrophy 6 The expression of MIAT and Ang II was increased, while miR-1246 was decreased in CRNV rat model. +other 30781783 hsa-mir-200c Carcinoma, Non-Small-Cell Lung This further led to repression of erlotinib as well as cisplatin sensitization, thus establishing the mechanistic role of miRNAs, particularly miR-200c and let-7c, in garcinol-mediated reversal of EMT and the resulting sensitization of NSCLC cells to standard therapies. +other 30781783 hsa-let-7c Carcinoma, Non-Small-Cell Lung This further led to repression of erlotinib as well as cisplatin sensitization, thus establishing the mechanistic role of miRNAs, particularly miR-200c and let-7c, in garcinol-mediated reversal of EMT and the resulting sensitization of NSCLC cells to standard therapies. +lncRNA target 30781750 hsa-mir-29a Liver Cirrhosis Collectively, MIR29a plays an important role during the trans-differentiation of aHSCs in the resolution of liver fibrosis, in part, through regulation of ATP6V1C1. +circulation_biomarker_diagnosis_up 30781685 hsa-mir-155 Multiple Myeloma The analysis of miR-155 expression indicates its down-regulation in MM patient-derived as compared to healthy plasma cells, thus pointing to a tumor suppressor role in this malignancy. +other 30781550 hsa-mir-142 Hepatitis C 3p distinguished HCC from cirrhosis (AUC = 0.94; sensitivity = 80%, specificity = 95%; p < 0.001), outperforming AFP (AUC = 0.64, p = 0.065). +other 30781550 hsa-mir-142 Carcinoma, Hepatocellular 3p distinguished HCC from cirrhosis (AUC = 0.94; sensitivity = 80%, specificity = 95%; p < 0.001), outperforming AFP (AUC = 0.64, p = 0.065). +other 30781519 hsa-mir-203 Zika Virus Infection ZIKV-modulated miRNAs including miR-155, miR-203, miR-29a, and miR3p are known to play critical role in flavivirus infection, anti-viral immunity and brain injury. +other 30781519 hsa-mir-29a Zika Virus Infection ZIKV-modulated miRNAs including miR-155, miR-203, miR-29a, and miR3p are known to play critical role in flavivirus infection, anti-viral immunity and brain injury. +other 30781519 hsa-mir-155 Zika Virus Infection ZIKV-modulated miRNAs including miR-155, miR-203, miR-29a, and miR3p are known to play critical role in flavivirus infection, anti-viral immunity and brain injury. +other 30781519 hsa-mir-124 Zika Virus Infection ZIKV-modulated miRNAs including miR-155, miR-203, miR-29a, and miR3p are known to play critical role in flavivirus infection, anti-viral immunity and brain injury. +other 30780111 hsa-mir-10a Reperfusion Injury, Renal Ischemia The primary purpose of the current study was to evaluate the renoprotective effects of the naringin (NAR) and trimetazidine (TMZ) on IR injury, renal hemodynamics, antioxidant capacity, microRNA-10a, and expression of apoptosis factors. +genetics_knock down_promote 30780105 hsa-mir-154 Carcinoma, Non-Small-Cell Lung In summary, knockdown of lncRNA SNHG20 suppressed proliferation, migration and invasion, and promotes apoptosis through up-regulating ZEB2 and RUNX2 expression by sponging miR-154 in NSCLC, providing a promising therapeutic target for NSCLC patients. +other 30779946 hsa-mir-142 Endometrial Neoplasms Among 561 differentially expressed miRNAs, 4 miRNAs (miR-4758, miR-876, miR-142, miR-190b) were demonstrated to be predictive biomarkers of overall survival (OS) for EC patients in training set. +other 30779946 hsa-mir-190b Endometrial Neoplasms Among 561 differentially expressed miRNAs, 4 miRNAs (miR-4758, miR-876, miR-142, miR-190b) were demonstrated to be predictive biomarkers of overall survival (OS) for EC patients in training set. +other 30779946 hsa-mir-4758 Endometrial Neoplasms Among 561 differentially expressed miRNAs, 4 miRNAs (miR-4758, miR-876, miR-142, miR-190b) were demonstrated to be predictive biomarkers of overall survival (OS) for EC patients in training set. +other 30779946 hsa-mir-876 Endometrial Neoplasms Among 561 differentially expressed miRNAs, 4 miRNAs (miR-4758, miR-876, miR-142, miR-190b) were demonstrated to be predictive biomarkers of overall survival (OS) for EC patients in training set. +genetics_knock down_promote 30779944 hsa-mir-1265 Stomach Neoplasms Notably, the knockdown of autophagy-related gene 12 (ATG12) impaired the effects of miR-1265 inhibition or CAB39 overexpression in GC. +lncRNA target 30779672 hsa-mir-181b Acquired Immunodeficiency Syndrome Microparticles from HIV seropositive men induced significantly greater endothelial cell release of interleukin-6 and interleukin-8 ( approximately 20% and approximately 35%, respectively) and nuclear factor-kappaB expression while suppressing anti-inflammatory microRNAs (miR-146a and miR-181b). +lncRNA target 30779672 hsa-mir-146a Acquired Immunodeficiency Syndrome Microparticles from HIV seropositive men induced significantly greater endothelial cell release of interleukin-6 and interleukin-8 ( approximately 20% and approximately 35%, respectively) and nuclear factor-kappaB expression while suppressing anti-inflammatory microRNAs (miR-146a and miR-181b). +circulation_biomarker_diagnosis_up 30779466 hsa-mir-146a Aortic Dissection RESULTS: Plasma level of miR-146a-5p is significantly higher in the AD group as compared with the control group. +genetics_knock down_promote 30779219 hsa-mir-4500 Carcinoma, Hepatocellular SNHG16 served as a sponge for miR-4500 in HCC and miR-4500 neutralized the influences of SNHG16 knockdown on HCC. +lncRNA target 30779126 hsa-mir-217 Melanoma miR-217 suppressed glutamine catabolism in melanoma cells by targeting glutaminase (GLS), the rate-limiting enzyme of glutamine catabolism. We also demonstrated that OIP5-AS1 acted as a sponge of miR-217 to upregulate GLS expression, thus promoting glutamine catabolism and melanoma growth. +transcription factor target 30779094 hsa-mir-770 Diabetic Nephropathies 5p was upregulated in the in vitro model of DN, and it might promote the development of DN through regulating podocyte apoptosis by targeting TRIAP1. +genetics_knock down_promote 30779090 hsa-mir-504 Leukemia, Myeloid, Acute 3p regulated the expression of MTHFD2 by binding to its 3'-UTR, and knockdown of MTHFD2 significantly suppressed AML cells proliferation, migration and invasion, and promoted apoptosis. +lncRNA target 30779084 hsa-mir-34a Breast Neoplasms MATERIALS AND METHODS: Breast cancer MCF-7 cells were transfected with miR-34a inhibitor or mimics to downregulate or upregulate the expression of miR-34a. +lncRNA target 30779083 hsa-mir-202 Thyroid Cancer, Papillary 3p may represent a novel therapeutic target of in PTC. +lncRNA target 30779082 hsa-mir-422a Thyroid Cancer, Papillary The regulating relationship between LINC00313 and miR-422a was investigated in PTC cells using luciferase reporter assays. CONCLUSIONS: Overall, our data demonstrated that SP1-induced LINC00313 contributed to PTC progression by via competitively binding to miR-422a, which may provide a novel therapeutic strategy for PTC. +genetics_knock down_promote 30779081 hsa-mir-1205 Adenocarcinoma of Lung Overexpression and knockdown in LUAD cells were chosen to evaluate the effect of miR-1205 on cell growth in vitro. +genetics_knock down_promote 30779080 hsa-mir-374b Lung Neoplasms Furthermore, PTEN knockdown enhanced migratory and proliferative abilities of LC cells, which were attenuated by co-transfection of microRNA-374b inhibitor. +circulation_biomarker_prognosis_ns 30779079 hsa-mir-182 Carcinoma, Non-Small-Cell Lung Therefore, the aim of this study was to detect the expression levels of serum miR-182, 200b and 205 in NSCLC patients, and to investigate their diagnostic and prognostic values. CONCLUSIONS: Our findings revealed that serum miR-182, 200b and 205 might serve as promising biomarkers for early detection and treatment of NSCLC. +genetics_overexpression_promote 30779075 hsa-mir-1181 Nasopharyngeal Carcinoma Functional investigations indicated that overexpression of miR-1181 suppressed NPC cells proliferation, migration and invasion. +lncRNA target 30779074 hsa-mir-601 Esophageal Squamous Cell Carcinoma CONCLUSIONS: MiR-601 suppressed the proliferation, invasion and migration of esophagus carcinoma cells by down-regulating HDAC6 expression. +lncRNA target 30779074 hsa-mir-601 Esophageal Neoplasms CONCLUSIONS: MiR-601 suppressed the proliferation, invasion and migration of esophagus carcinoma cells by down-regulating HDAC6 expression. +genetics_overexpression_promote 30779068 hsa-mir-150 Urinary Bladder Neoplasms CONCLUSIONS: LncSNHG14 overexpression accelerates proliferative potential and cell cycle progression of BCa cells through absorbing miRNA +lncRNA target 30779066 hsa-mir-95 Prostatic Neoplasms 3p promoted the development of PCa via targeting DKK3 and activating the Wnt/beta-catenin pathway. +transcription factor target 30779065 hsa-mir-492 Prostatic Neoplasms Silencing of SOCS2 could neutralize the inhibitory function of miR-492 inhibitor in PCa cells. +lncRNA target 30779064 hsa-mir-340 Osteosarcoma 5p in OS and U2OS cells could inhibit the course of OS by negatively regulating Wnt/beta-catenin signaling pathway through targeting STAT3 gene. +genetics_overexpression_promote 30779062 hsa-mir-106a Melanoma MiR-106a was upregulated in melanoma cells, and its overexpression attenuated the effects caused by upregulating Cx43 expression. +circulation_biomarker_diagnosis_down 30779060 hsa-mir-217 Osteoporosis RESULTS: OP patients presented a higher serum level of miRNA-217 and lower serum levels of circ-VANGL1 and RUNX2 relative to non-OP patients. +lncRNA target 30779057 hsa-mir-34a Pre-Eclampsia CONCLUSIONS: MiR-34a regulates uPA system through the Notch signal transduction, thereby regulating the invasion of placental trophoblasts in patients with preeclampsia. +transcription factor target 30778336 hsa-mir-27b Obesity Conclusions: High expression of miR-27b-3p in eWAT inhibits browning ability and leads to visceral fat accumulation. It is suggested miR-27b-3p may become a potential therapeutic option for visceral obesity and its associated diseases. +lncRNA target 30778287 hsa-mir-155 Inflammation The results revealed that by targeting LXRalpha, microRNA-155 enhanced NF-kappaB signaling activation and facilitated immune inflammation in heat stress-treated BV-2 cells. +other 30778058 hsa-mir-135 Pancreatic Carcinoma Here, we show that microRNA-135 is significantly increased in PDAC patient samples compared to adjacent normal tissue. Consistently, miR-135 silencing sensitizes PDAC cells to glutamine deprivation and represses tumor growth in vivo. +genetics_overexpression_promote 30778047 hsa-let-7d Cholestasis Using miRNA-sequencing analysis followed by qPCR validation, we identified marked upregulation of eight members of the let-7 family in cholestatic livers by bile duct ligation (BDL) and H19 overexpression. Taken together, this study revealed for the first time that H19 promoted let-7 expression by decreasing PTBP1's expression level and its binding to the let-7 precursors in cholestasis. +genetics_overexpression_promote 30778047 hsa-let-7 Cholestasis Using miRNA-sequencing analysis followed by qPCR validation, we identified marked upregulation of eight members of the let-7 family in cholestatic livers by bile duct ligation (BDL) and H19 overexpression. Taken together, this study revealed for the first time that H19 promoted let-7 expression by decreasing PTBP1's expression level and its binding to the let-7 precursors in cholestasis. +other 30778022 hsa-mir-34b Urinary Bladder Neoplasms MicroRNA (miRNA) has been indicated in the progression and tumorigenesis of many types of cancer, but the effect of miR-34b-3p in bladder cancer (BCa) cells is still unknown. Further experiments suggested that the CCND2 gene and the P2RY1 gene act in concert to negatively correlate with miR-34b-3p effect on BCa multidrug-chemoresistance. +circulation_biomarker_diagnosis_ns 30777929 hsa-mir-20a Pancreatic Carcinoma Retrospective study suggested that plasma miR-20a-5p level was correlated with gemcitabine resistance in PC patient. +lncRNA target 30777884 hsa-mir-33a Spastic Paraplegia, Hereditary We demonstrated that inhibition of miR-33a, a major form of miR-33 in human neurons, via locked nucleic acid (LNA)-anti-miR ameliorated the pathological phenotype in hereditary spastic paraplegia (HSP)-SPG4 patient induced pluripotent stem cell (iPSC)-derived cortical neurons. +lncRNA target 30777884 hsa-mir-3 Spastic Paraplegia, Hereditary We demonstrated that inhibition of miR-33a, a major form of miR-33 in human neurons, via locked nucleic acid (LNA)-anti-miR ameliorated the pathological phenotype in hereditary spastic paraplegia (HSP)-SPG4 patient induced pluripotent stem cell (iPSC)-derived cortical neurons. +genetics_knock down_suppress 30777616 hsa-mir-125a Osteosarcoma In addition, ANRIL knockdown resulted in a reduction in STAT3, a target of miR-125a-5p, in osteosarcoma cells. +lncRNA target 30776865 hsa-mir-497 Squamous Cell Carcinoma of Head and Neck Objective: To study the effects of miR-497 and CDK6 on the growth of laryngeal squamous cell carcinoma (LSCC). miR-497, functioning as a tumor suppressor gene, inhibits the growth of LSCC by targeting CDK6. +transcription factor target 30776646 hsa-mir-146a Inflammation In rat model of OA, the expression of miR-146a and Decorin in cartilage tissues was repressed by Kaempferol. These data suggested that Kaempferol exerted potential anti-OA effects through down-regulation of miR-146a, and thus repressing the expression of Decorin. +genetics_overexpression_suppress 30776580 hsa-mir-223 Pancreatic Carcinoma Consistently, ectopic overexpression of PDS5B reversed miR +transcription factor target 30776032 hsa-mir-146b Fatty Liver Our results indicated that myricetin attenuated hepatic steatosis via the miR-146b/TRb pathway and should be considered for the management of NAFLD conditions. +other 30775942 hsa-mir-378c Osteoarthritis 5p/miR-378c/CPNE1/Cdh2/PRDM16/ were validated in CSPCs from OA patients. +other 30775942 hsa-mir-493 Osteoarthritis 5p/miR-378c/CPNE1/Cdh2/PRDM16/ were validated in CSPCs from OA patients. +other 30775942 hsa-mir-22 Osteoarthritis 5p/miR-378c/CPNE1/Cdh2/PRDM16/ were validated in CSPCs from OA patients. +other 30775882 hsa-mir-382 Breast Neoplasms The interaction of microRNA and lncRNA results exhibited upregulated MIR382-5P and lncRNA 362 in ER+ breast cancer compared to non-cancerous breast. +other 30775601 hsa-mir-375 Diabetes Mellitus, Type 2 Long-term, prospective human studies are required to elucidate whether miRNA-375 can evolve as a key player in diagnosis and prognosis of type 2 diabetes. +other 30775405 hsa-mir-195 Ischemic Stroke We intravenously injected miR-195 carried by nanoparticles into rats with either ischemic or hemorrhagic stroke in the acute stage. Our data demonstrated that miR-195 possesses the potential to become a new drug to treat acute ischemic and hemorrhagic stroke. +other 30774764 hsa-mir-194 Ovarian Neoplasms Collectively, our results show that restoring miR5p expression resensitizes EOCs to paclitaxel, and this may be exploited as a therapeutic option. +other 30774681 hsa-mir-21 Wilms Tumor CONCLUSION: Low expression of miR-21 in WT might pinpoint the weak involvement of this miRNA in the pathogenesis of this cancer. +genetics_knock down_suppress 30774445 hsa-mir-600 Lung Neoplasms CONCLUSION: These data suggested that miR-600 inhibited lung cancer via down-regulating METTL3 expression, and knockdown of METTL3 might be used as a novel strategy for lung cancer therapy. +circRNA target 30774431 hsa-mir-492 Breast Neoplasms Hsa_circ_0072309 suppressed breast cancer cell proliferation, migration, and invasion by inhibiting miR-492. +genetics_overexpression_promote 30774424 hsa-mir-21 Liver Neoplasms CONCLUSION: The study suggested that overexpression of miR +circulation_biomarker_diagnosis_up 30774409 hsa-mir-215 Hepatitis C CONCLUSION: Cell-free miR-215 and serum SCCA-IgM could be used for early diagnosis of HCC either each one as a single marker or with AFP complement measurement. +circulation_biomarker_diagnosis_up 30774409 hsa-mir-215 Carcinoma, Hepatocellular CONCLUSION: Cell-free miR-215 and serum SCCA-IgM could be used for early diagnosis of HCC either each one as a single marker or with AFP complement measurement. +lncRNA target 30774397 hsa-mir-21 Diabetic Foot Our results suggest that miRNA-21 may regulate the expression of NF-kappaB through PDCD4 where it plays an anti-inflammatory role and promote proliferation in infected DFUs treated by PRP. +genetics_overexpression_promote 30774383 hsa-mir-135a Stomach Neoplasms Furthermore, we found that TRAF5 overexpression was negatively correlated with miR-135a expression in GC tissues. +genetics_overexpression_promote 30774372 hsa-mir-206 Stomach Neoplasms Functional studies demonstrated that miR-206 overexpression significantly suppresses GC cell proliferation, migration, and invasion, and induces apoptosis in vitro. +lncRNA target 30774371 hsa-mir-101 Carcinoma, Non-Small-Cell Lung 5p restrained the progression of NSCLC cells by targeting CXCL6 and might function as a potential therapeutic target for NSCLC. +genetics_knock down_promote 30774367 hsa-mir-505 Stomach Neoplasms In addition, knockdown miR-505 induced the invasion and proliferation of GC cells. +lncRNA target 30774364 hsa-mir-217 Uterine Cervical Neoplasms Overregulation of miR-217 markedly suppressed the aggressiveness of cervical cancer cell and induced cell apoptosis through regulating V-Ki-Ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS). +epigenetics 30774362 hsa-mir-124 Colorectal Neoplasms They indicate that miR-124 is methylated during carcinogenesis and functions as a tumor-suppressor in colorectal cancer. +genetics_overexpression_promote 30774308 hsa-mir-339 Carcinoma, Hepatocellular Overexpression of ZNF689 in miR +genetics_overexpression_promote 30774011 hsa-mir-544 Liver Neoplasms Compared with a control group, lncRNA GAS5, RUNX3, and NCR1 were down-regulated in NK cells of patients with liver cancer, whereas miR-544 expression was up-regulated in NK cells of patients with liver cancer. LncRNA GAS5 overexpression enhances the killing effect of NK cell on liver cancer through regulating miR-544/RUNX3. +genetics_knock down_promote 30773847 hsa-mir-876 Osteosarcoma 5p knockdown promoted cell proliferation, migration and invasion in both U2OS and MG63 cells. +lncRNA target 30773606 hsa-mir-449a Brain Ischemia miR-449a functions in ischemic stroke via directly targeting AREG. +lncRNA target 30773530 hsa-mir-193a Nasopharyngeal Neoplasms RESULTS miR-193a-3p promotes NPC radio-resistance, and the SRSF2 gene is the direct target for miR-193a-3p in NPC, and thus is negatively correlated with NPC radio-resistance. +genetics_overexpression_promote 30772912 hsa-mir-21 Adenomyosis Taken together, these results illustrate that miR-21 promotes endometrial decidualization by inhibiting KLF12, and miR-21 overexpression reverses the poor decidual response of hESCs in patients with adenomyosis in vitro. +other 30771749 hsa-mir-21 Metabolic Diseases 5p participated in the development of MetS associated with Cu. +other 30771618 hsa-mir-200b Adenocarcinoma of Lung Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) contributed to the low miR-200b level in DTX-resistant LUAD cells. +lncRNA target 30771618 hsa-mir-200b Syphilis E2F transcription factor 3 (E2F3) and zinc-finger E-box binding homeobox 1 (ZEB1) were two targets of miR-200b and mediated the function of MALAT1 in DTX-resistant LUAD cells. +transcription factor target 30771436 hsa-mir-497 Esophageal Neoplasms Mechanistically, metformin induces pyroptosis of ESCC by targeting miR-497/PELP1 axis. +other 30771307 hsa-mir-25 Heart Failure Therefore, we aimed to investigate whether Six1 and PRC2 are indeed involved in the regulation of the miR-25 level in the setting of heart failure. Collectively, these data showed that the PRC2-Six1-miR-25 signaling axis is involved in heart failure. +other 30770954 hsa-mir-342 Neuroblastoma We found miR-323a-5p and miR5p to be capable of reducing cell proliferation in multiple neuroblastoma cell lines in vitro and in vivo, thereby providing a proof of concept for miRNA-based therapies for neuroblastoma. +other 30770954 hsa-mir-23a Neuroblastoma We found miR-323a-5p and miR5p to be capable of reducing cell proliferation in multiple neuroblastoma cell lines in vitro and in vivo, thereby providing a proof of concept for miRNA-based therapies for neuroblastoma. +circulation_biomarker_diagnosis_up 30770930 hsa-mir-206 Schizophrenia These include hsa-miR-206, which is the most upregulated miRNA in the blood exosomes of SCZ patients and that previously reported to regulate brain-derived neurotrophic factor expression, which we showed reduced mRNA and protein levels in the blood of SCZ patients. +other 30770877 hsa-mir-34a Stomach Neoplasms Taken together, our findings support a model in which the KLF5, MYC/LINC00346/miR-34a-5p cross-talk served as critical effectors in GC tumorigenesis and progression, suggesting a new therapeutic direction in the treatment of GC. +lncRNA target 30770796 hsa-mir-144 Colorectal Neoplasms We found that lncRNA ZNFX1-AS1 is significantly upregulated in CRC, and the newly identified lncRNA ZNFX1-AS1-miREZH2 axis is involved in the regulation of CRC progression, which might be used as potential therapeutic targets for CRC patients. +circulation_biomarker_diagnosis_up 30770794 hsa-mir-451a Colorectal Neoplasms Over-expressing miR-451a or silencing BAP31 suppressed the proliferation and apoptosis of CRC cells by increasing the expressions of endoplasmic reticulum stress (ERS)-associated proteins, including GRP78/BIP, BAX, and PERK/elF2/ATF4/CHOP, which resulted in increased ERS, cytoplasmic calcium ion flowing, and apoptosis of CRC cells. +circulation_biomarker_diagnosis_ns 30770776 hsa-mir-223 Carcinoma, Ovarian Epithelial Finally, circulating exosomal miR-223 levels were closely related to the recurrence of EOC. +other 30770602 hsa-mir-191 Colorectal Neoplasms In this study, we used the gene ontology analyses, the Kyoto Encyclopedia of Genes and Genomes pathway analyses and gene set enrichment analysis to indicate that miR-3191 was involved in the regulation of transforming growth factor beta (TGF-BETA) signal pathway in CRC. By transwell migration and invasion assays, we showed that miR-3191 promoted CRC cell migration and invasion by downregulating TGFBR2. +lncRNA target 30770339 hsa-mir-34a Bronchopulmonary Dysplasia We present here the first identification of a pathology-relevant microRNA/mRNA target interaction in aberrant lung alveolarization and highlight the translational potential of targeting the miR-34a/Pdgfra interaction to manage arrested lung development associated with preterm birth. +transcription factor target 30769772 hsa-mir-766 Arthritis, Rheumatoid 3p, findings that may aid in the development of therapies to suppress inflammation, not only in RA but also in other diseases. +transcription factor target 30769772 hsa-mir-766 Inflammation These results indicate the novel function of miR3p, findings that may aid in the development of therapies to suppress inflammation, not only in RA but also in other diseases. +circulation_biomarker_prognosis_ns 30769280 hsa-mir-126 Cardiovascular Diseases The aim of this research was to investigate circulating expression levels of three miRNAs (miR-126, miR-155, and miR-145) proposed as predictive CVD biomarkers in Mexican women exposed to inorganic arsenic via drinking water. Alterations in the serum expression levels of miR-155 and miR-126 may be associated with the onset and development of cardiovascular diseases, hence miRNAs could be proposed as prognostic CVD biomarkers. +circulation_biomarker_diagnosis_ns 30769280 hsa-mir-145 Cardiovascular Diseases The aim of this research was to investigate circulating expression levels of three miRNAs (miR-126, miR-155, and miR-145) proposed as predictive CVD biomarkers in Mexican women exposed to inorganic arsenic via drinking water. +circulation_biomarker_prognosis_ns 30769280 hsa-mir-155 Cardiovascular Diseases The aim of this research was to investigate circulating expression levels of three miRNAs (miR-126, miR-155, and miR-145) proposed as predictive CVD biomarkers in Mexican women exposed to inorganic arsenic via drinking water. Alterations in the serum expression levels of miR-155 and miR-126 may be associated with the onset and development of cardiovascular diseases, hence miRNAs could be proposed as prognostic CVD biomarkers. +lncRNA target 30769134 hsa-mir-672 Osteoporosis Sarcopenia was also alleviated by miR +lncRNA target 30769134 hsa-mir-672 Sarcopenia Sarcopenia was also alleviated by miR +transcription factor target 30768922 hsa-mir-26b Osteoarthritis It bears therapeutic potential if miR-26b could regulate osteogenesis and antagonize Dex induced Osteoporosis (OP). CONCLUSION: Our findings indicate that miR-26b promoted BMSC osteogenesis by directly targeting GSK3beta and activating canonical Wnt signal pathway, suggesting miR-26b might be serve as potential therapeutic candidate of osteoporosis. +lncRNA target 30768589 hsa-mir-933 Breast Neoplasms CONCLUSIONS Results from the present study suggest that TFAP2A-AS1 acts as a tumor suppressor in BC via the miR-933/SMAD2 axis. +other 30767608 hsa-mir-23a Breast Neoplasms Members of the Mir-23a cluster (MIR23A, MIR24-2 and MIR27A) are involved in breast cancer (BC). +genetics_GWAS 30767608 hsa-mir-27a Breast Neoplasms METHODS: In the present study, miR-23a/24-2/27a cluster was screened for genetic mutation in BC patients. +other 30767608 hsa-mir-24-2 Breast Neoplasms Members of the Mir-23a cluster (MIR23A, MIR24-2 and MIR27A) are involved in breast cancer (BC). +transcription factor target 30767148 hsa-mir-653 Pancreatic Neuroendocrine Tumor Although this is a small study, we conclude that miRNA-3653 upregulation may be associated with an increased risk of metastatic disease in PNETS, perhaps through interaction with ATRX and the alternate lengthening of telomeres pathway. +other 30767148 hsa-mir-4417 Pancreatic Neuroendocrine Tumor In total 506 miRNAs were differentially expressed between the L and DM groups, with four miRNAs (miR-3653 upregulated, and miR-4417, miR3p and miR-664b-3p downregulated) showing statistical significance. +other 30767148 hsa-mir-664b Pancreatic Neuroendocrine Tumor In total 506 miRNAs were differentially expressed between the L and DM groups, with four miRNAs (miR-3653 upregulated, and miR-4417, miR3p and miR-664b-3p downregulated) showing statistical significance. +lncRNA target 30766610 hsa-mir-219 Esophageal Squamous Cell Carcinoma CCNA2 was identified and confirmed as a direct downstream target of miR +other 30766462 hsa-mir-29 Ovarian Diseases The aim of the present study was to evaluate the effects of six weeks of combined resistance-endurance (RE) training on microRNA-29 expression in the heart of ovariectomised rats. CONCLUSIONS: Our findings suggest that the six weeks of regular RE training attenuate the reduction in heart muscle microRNA-29 expression observed in ovariectomised rates. +lncRNA target 30765689 hsa-mir-155 Vascular Diseases These data suggest that NF-kappaB-responsive miR-155 is a novel negative regulator of VSMC functions by impairing the sGC/cGMP pathway, which is essential for maintaining the VSMC contractile phenotype and vasorelaxation, offering a new therapeutic target for the treatment of atherosclerosis and preeclampsia. +circulation_biomarker_diagnosis_up 30765325 hsa-mir-221 Multiple Myeloma Here we demonstrated that miR-221/222 were upregulated in plasma cells from patients with MM, especially those with relapsed or refractory disease. +circulation_biomarker_diagnosis_up 30765325 hsa-mir-222 Multiple Myeloma Here we demonstrated that miR-221/222 were upregulated in plasma cells from patients with MM, especially those with relapsed or refractory disease. +other 30765226 hsa-mir-9 Stomach Neoplasms GSK1059615 blocked PI3K-AKT-mTOR cascade activation, inducing microRNA-9 downregulation but LMX1A (LIM homeobox transcription factor 1alpha) upregulation in GC cells. +lncRNA target 30765222 hsa-mir-552 Osteosarcoma Above all, our data suggest that miR-552 promoted migration, invasion and MMPs expression of osteosarcoma by targeting TIMP2, and represent a novel potential therapeutic target for osteosarcoma. +other 30764896 hsa-mir-326 Adenocarcinoma of Lung Therefore, inactivation of hsa_circ_0003998 or activation of miR-326 could be a novel approach for the treatment of LAD. +genetics_overexpression_promote 30764893 hsa-mir-140 Cholangiocarcinoma The data also demonstrated that miR-140 could act as a target of SNHG1 in CCA and inhibited CCA cell proliferation and invasion, whereas the inhibition effects were relieved by overexpression of SNHG1. +other 30764491 hsa-mir-363 Marek Disease Conversely, oncomiRs originating from cellular (miRs 106a-363) and MDV miRNA clusters were more abundant in TEX compared to VEX. +other 30764491 hsa-mir-106a Marek Disease Conversely, oncomiRs originating from cellular (miRs 106a-363) and MDV miRNA clusters were more abundant in TEX compared to VEX. +other 30763910 hsa-mir-17 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma hsa-mir-106a-363 is a paralogue of prototypic oncogenic hsa-mir92 cluster with yet unestablished role in the pathogenesis of T-ALL. +genetics_overexpression_suppress 30763770 hsa-mir-375 Fibrolamellar hepatocellular carcinoma RESULTS We identified miR-375 as the most dysregulated miRNA in primary FLC tumors (27-fold down-regulation; P = .009). CONCLUSIONS We identified miR-375 as the most down-regulated miRNA in FLC tumors and showed that overexpression of miR-375 mitigated tumor cell growth and invasive potential. +other 30763668 hsa-mir-155 Uveitis MiR-146a, miR-146a-5p, miR-155, miR-182, miR3p, have been found to be possibly associated with uveitis disease in both, human and animal species. +other 30763668 hsa-mir-182 Uveitis MiR-146a, miR-146a-5p, miR-155, miR-182, miR3p, have been found to be possibly associated with uveitis disease in both, human and animal species. +other 30763668 hsa-mir-223 Uveitis MiR-146a, miR-146a-5p, miR-155, miR-182, miR3p, have been found to be possibly associated with uveitis disease in both, human and animal species. +other 30763668 hsa-mir-146a Uveitis MiR-146a, miR-146a-5p, miR-155, miR-182, miR3p, have been found to be possibly associated with uveitis disease in both, human and animal species. +other 30762435 hsa-mir-204 Uterine Cervical Neoplasms 1, were identified. +other 30762435 hsa-mir-194-1 Uterine Cervical Neoplasms 1, were identified. +other 30762435 hsa-mir-150 Uterine Cervical Neoplasms 1, were identified. +lncRNA target 30762286 hsa-mir-28 Colorectal Neoplasms Moreover, we explored the molecular mechanisms accounting for the dysregulation of SSRP1 in CRC and identified microRNA +other 30761836 hsa-mir-3 Acute Lung Injury CONCLUSION: This study is the first to confirm that both miR-33 and RIP140 participate in LPS-induced PMVEC injury and ALI, which may help uncover the mechanism of ALI +genetics_knock down_promote 30761271 hsa-mir-125a Carcinoma, Endometrioid In conclusion, high-expression of CDKN2B-AS is associated with a poor response to paclitaxel of EC patients, and knockdown of CDKN2B-AS inhibits paclitaxel resistance through miR-125a-5p-Bcl2/MRP4 pathway in EC patients. +lncRNA target 30761256 hsa-mir-9-1 Adenocarcinoma of Lung In all, we identified a total of 13 DEmiRNAs, 2301 DEmRNAs and 232 DEmiRNA-target DEmRNA pairs between LUAD and adjacent tissues and selected nine DEmiRNAs (hsa-mir +lncRNA target 30761256 hsa-mir-153 Adenocarcinoma of Lung In all, we identified a total of 13 DEmiRNAs, 2301 DEmRNAs and 232 DEmiRNA-target DEmRNA pairs between LUAD and adjacent tissues and selected nine DEmiRNAs (hsa-mir +lncRNA target 30761256 hsa-mir-9 Adenocarcinoma of Lung In all, we identified a total of 13 DEmiRNAs, 2301 DEmRNAs and 232 DEmiRNA-target DEmRNA pairs between LUAD and adjacent tissues and selected nine DEmiRNAs (hsa-mir +lncRNA target 30761256 hsa-mir-9-2 Adenocarcinoma of Lung In all, we identified a total of 13 DEmiRNAs, 2301 DEmRNAs and 232 DEmiRNA-target DEmRNA pairs between LUAD and adjacent tissues and selected nine DEmiRNAs (hsa-mir +lncRNA target 30761256 hsa-mir-486-2 Adenocarcinoma of Lung In all, we identified a total of 13 DEmiRNAs, 2301 DEmRNAs and 232 DEmiRNA-target DEmRNA pairs between LUAD and adjacent tissues and selected nine DEmiRNAs (hsa-mir +lncRNA target 30761256 hsa-mir-577 Adenocarcinoma of Lung In all, we identified a total of 13 DEmiRNAs, 2301 DEmRNAs and 232 DEmiRNA-target DEmRNA pairs between LUAD and adjacent tissues and selected nine DEmiRNAs (hsa-mir +lncRNA target 30761256 hsa-mir-486-1 Adenocarcinoma of Lung In all, we identified a total of 13 DEmiRNAs, 2301 DEmRNAs and 232 DEmiRNA-target DEmRNA pairs between LUAD and adjacent tissues and selected nine DEmiRNAs (hsa-mir +lncRNA target 30761256 hsa-mir-210 Adenocarcinoma of Lung In all, we identified a total of 13 DEmiRNAs, 2301 DEmRNAs and 232 DEmiRNA-target DEmRNA pairs between LUAD and adjacent tissues and selected nine DEmiRNAs (hsa-mir +lncRNA target 30761256 hsa-mir-4732 Adenocarcinoma of Lung In all, we identified a total of 13 DEmiRNAs, 2301 DEmRNAs and 232 DEmiRNA-target DEmRNA pairs between LUAD and adjacent tissues and selected nine DEmiRNAs (hsa-mir +lncRNA target 30760828 hsa-mir-17 Kidney Diseases, Cystic We designed anti-miRs to individually inhibit miR-17, miR-18, miR-19 or miR-25 families in an orthologous ADPKD model. +lncRNA target 30760709 hsa-mir-210 Endometriosis 3p inhibitor or vitamin C suppressed the growth of endometriotic lesions. +other 30760335 hsa-mir-103a Venous Thromboembolism 5p, miR-103a-3p, and miR-30c-5p) were found to be associated with recurrent VTE after multiple correction test and conditional logistic regression analysis. +other 30760335 hsa-mir-21 Venous Thromboembolism 5p, miR-103a-3p, and miR-30c-5p) were found to be associated with recurrent VTE after multiple correction test and conditional logistic regression analysis. +other 30760335 hsa-mir-106a Venous Thromboembolism 5p, miR-103a-3p, and miR-30c-5p) were found to be associated with recurrent VTE after multiple correction test and conditional logistic regression analysis. +other 30760335 hsa-mir-27b Venous Thromboembolism 5p, miR-103a-3p, and miR-30c-5p) were found to be associated with recurrent VTE after multiple correction test and conditional logistic regression analysis. +other 30760335 hsa-mir-26b Venous Thromboembolism 5p, miR-103a-3p, and miR-30c-5p) were found to be associated with recurrent VTE after multiple correction test and conditional logistic regression analysis. +other 30760335 hsa-mir-15b Venous Thromboembolism 5p, miR-103a-3p, and miR-30c-5p) were found to be associated with recurrent VTE after multiple correction test and conditional logistic regression analysis. +other 30760335 hsa-mir-197 Venous Thromboembolism 5p, miR-103a-3p, and miR-30c-5p) were found to be associated with recurrent VTE after multiple correction test and conditional logistic regression analysis. +lncRNA target 30760304 hsa-mir-30 Thyroid Neoplasms CONCLUSION: The present findings provide evidence that LDR-induced PAX8 acts as an important regulator for suppression of thyroid carcinogenesis through novel STAT3/miR5p pathway in thyroid cancers. +exosome 30760290 hsa-mir-126 Acute Lung Injury We previously found that endothelial progenitor cell (EPC) exosomes prevent endothelial dysfunction and lung injury in sepsis in part due to their encapsulation of miRNA-126. +exosome 30760290 hsa-mir-126 Endotoxemia We previously found that endothelial progenitor cell (EPC) exosomes prevent endothelial dysfunction and lung injury in sepsis in part due to their encapsulation of miRNA-126. +other 30760287 hsa-mir-27a Atrial Fibrillation Finally, co-expressed DEGs of ZNF566, PDZK1IP1, ZFHX3, and PITX2 coupled with corresponding predicted miRNAs, especially miR-27a-3p, miR-27b-3p, and miR3p may be significantly associated with AF-related stroke. +genetics_overexpression_promote 30760089 hsa-mir-633 Lupus Erythematosus, Systemic In Jurkat and lupus CD4(+)T cells, overexpression of miR-633 could result in lower levels of AKT1 and mTOR. +genetics_GWAS 30758239 hsa-mir-24 Arthritis, Rheumatoid AIM: The present study looked for variation in the miRNA-24 sequence, and evaluated the associations between the dihydrofolate reductase (DHFR) gene-829 C-T polymorphism and plasma DHFR concentrations with response to methotrexate (MTX) treatment in Mexican patients with rheumatoid arthritis (RA). CONCLUSION: The -829C-T polymorphism of DHFR gene was not associated with response to MTX by RA patients, and no variations were found in the miRNA-24 sequence that might modify the response to treatment or DHFR enzyme levels in a Mexican population with RA. +transcription factor target 30756509 hsa-mir-98 Lung Neoplasms The inhibition of miR-98 on the luciferase activities of wild-type 3' untranslated region vectors of WNT1 was clearly revealed in lung cancer cells. +other 30756482 hsa-mir-26a Carcinoma, Non-Small-Cell Lung NF-kappaB activation negatively regulated by miR-26a was confirmed in NSCLC. CONCLUSION: Together, these results provide evidence of the mechanisms of the ANXA1-NF-kappaB-miR-26a regulatory pathway in the invasion and migration in NSCLC. +circulation_biomarker_diagnosis_ns 30756471 hsa-mir-29b Non-alcoholic Fatty Liver Disease RESULTS: Serum miR-29b, but not miR-29a or miR-29c, was positively associated with NAFLD (odds ratio [OR] 2.04 [1.16- 3.58], P = 0.013). CONCLUSIONS: Serum miR-29b was associated with intrahepatic lipid content and NAFLD in a Chinese population-based study. +circulation_biomarker_diagnosis_ns 30756418 hsa-mir-939 Nephrotic Syndrome 5p and decreased expression of CD2AP in the peripheral blood of patients with NS. +genetics_overexpression_promote 30755810 hsa-mir-758 Osteosarcoma In addition, functional assays revealed that miR-758 overexpression led to a significant decrease in OS cell growth and metastasis in vitro, whereas miR-758 inhibition had the opposite effect on OS cells. +lncRNA target 30755600 hsa-mir-1249 Colorectal Neoplasms Our study indicated that P53-induced miR-1249 may suppress CRC growth, metastasis and angiogenesis by targeting VEGFA and HMGA2, as well as regulate Akt/mTOR pathway and EMT process in the initiation and development of CRC. +lncRNA target 30755599 hsa-mir-141 Pulmonary Fibrosis Therefore, our finding suggested lncRNA ZEB1-AS1 as a new profibrotic molecule that acts as a regulator of miR3p/ZEB1 axis during lung fibrosis and demonstrated ZEB1-AS1 as a potential therapeutic target for the prevention and treatment of pulmonary fibrosis. +other 30755588 hsa-mir-149 Atherosclerosis Together, these findings identified a macrophage MIAT/miR5p /CD47 pathway as a key factor in the development of necrotic atherosclerotic plaques. +other 30755244 hsa-mir-146a ankylosing spondylitis 1 Mir-146a-5p levels correlated inversely with the degree of inflammation in axSpA patients. +genetics_GWAS 30755230 hsa-mir-223 Carcinoma, Non-Small-Cell Lung 3p might be a new therapeutic target in LSCC bearing p53 mutations. +other 30755200 hsa-let-7d Squamous Cell Carcinoma of Head and Neck Thus, let-7d and miR-205 are good candidates for new HNSCC biomarkers. +other 30755200 hsa-mir-205 Squamous Cell Carcinoma of Head and Neck Thus, let-7d and miR-205 are good candidates for new HNSCC biomarkers. +lncRNA target 30755102 hsa-mir-143 Breast Neoplasms In summary, miR-143 could be a potential predictor of response to neoadjuvant therapy and it may function as a divergent regulator of diverse signaling networks to suppress cell proliferation and migration in breast cancer. +lncRNA target 30754729 hsa-mir-584 Melanoma 3p might contribute to metformininducedgrowth and motility suppression in melanoma cells through silencing their target genesEFEMP1 and SCAMP3. +lncRNA target 30754729 hsa-mir-192 Melanoma 3p might contribute to metformininducedgrowth and motility suppression in melanoma cells through silencing their target genesEFEMP1 and SCAMP3. +other 30753994 hsa-mir-340 Influenza, Human We now report that microRNA-340 (miR340) is downregulated following influenza A and other RNA virus infections, implying that host cells deplete miR340 as an antiviral defense mechanism. +exosome 30753992 hsa-mir-192 Hepatitis C In this study, we aimed to determine the roles and mechanisms of HCV-induced miR-192 expression during chronic liver injury and fibrosis and to identify potential target of the liver disease. This study revealed a novel mechanism of HCV-induced liver fibrosis and identified exosomal miR-192 as a major regulator and potential treatment target for HCV-mediated hepatic fibrosis. +lncRNA target 30753902 hsa-mir-15 Atrial Premature Complexes Our results demonstrated that the transcription of miR-15/16 was enhanced by c-Fos, c-Jun, and CREB, important elements of the MAPK pathway, and miR-15/16 in turn directly targeted adenomatous polyposis coli (APC) protein, a major member of the beta-catenin degradation complex. +lncRNA target 30753902 hsa-mir-16 Atrial Premature Complexes Our results demonstrated that the transcription of miR-15/16 was enhanced by c-Fos, c-Jun, and CREB, important elements of the MAPK pathway, and miR-15/16 in turn directly targeted adenomatous polyposis coli (APC) protein, a major member of the beta-catenin degradation complex. +other 30753838 hsa-mir-663a Osteosarcoma Further mechanistic studies revealed that miR-663a induced by ER stress directly bound to the 3'UTR of ZBTB7A and contributed to ER stress-induced ZBTB7A downregulation in osteosarcoma cells. Collectively, our findings reveal the prosurvival role of ZBTB7A in osteosarcoma adaptation to ER stress and suggest that the miR-663a-ZBTB7A-LncRNAGAS5 pathway is essential for the survival of human osteosarcoma cells under ER stress. +tissue_expression_ns 30753517 hsa-mir-24 Genetic Diseases, Inborn Our previous study demonstrated that elevation of microRNA-24 (miR-24) in a diabetic setting caused beta cell dysfunction and replicative deficiency. +tissue_expression_ns 30753517 hsa-mir-24 Diabetes Mellitus Our previous study demonstrated that elevation of microRNA-24 (miR-24) in a diabetic setting caused beta cell dysfunction and replicative deficiency. This study not only provides a novel mechanism by which miR-24 dominates beta cell turnover under persistent metabolic stress but also offers a therapeutic consideration for treating diabetes by inducing dedifferentiated beta cells to re-differentiation. +other 30753098 hsa-mir-103a Atrial Fibrillation Notably, expression of 5 miRNAs (miRNA-103a, -107, -320d, -486, and let-7b) was elevated by more than 4.5-fold in patients with persistent AF. +other 30753098 hsa-let-7b Atrial Fibrillation Notably, expression of 5 miRNAs (miRNA-103a, -107, -320d, -486, and let-7b) was elevated by more than 4.5-fold in patients with persistent AF. +tissue_expression_ns 30747316 hsa-mir-375 Squamous Cell Carcinoma of Head and Neck Subgroup analysis based on tumor type found that lower expression of miR-375 was significantly related with poor OS in patients with esophageal squamous cell carcinoma (ESCC) (HR 1.58, 95% CI 1.29-1.94, P < 0.001) and head and neck squamous cell carcinoma (HNSCC) (HR 1.59, 95% CI 1.16-2.18, P = 0.004). CONCLUSIONS: This meta-analysis demonstrated that the downexpression of miR-375 was significantly correlated with poor OS in patients with SCCs and indicated the potential clinical use of miR-375 as a molecular biomarker, particularly in assessing prognosis for patients with ESCC and HNSCC. +lncRNA target 30747229 hsa-mir-223 Acute Lung Injury Furthermore, TLR4 inhibitor or NLRP3 inhibitor reduced the proinflammatory effect of miR223 downregulation in ALI. +lncRNA target 30747224 hsa-mir-135a Neoplastic Cells, Circulating The present study investigated the role of microRNA135a (miR135a) in cutaneous Tcell lymphoma (CTCL) proliferation. The substantially increased mRNA and protein levels of GATA3 may be associated with the downregulation of miR135a, leading to Tcell deregulation and proliferation through GATA3/TOX regulation and subsequently causing CTCL. +lncRNA target 30747224 hsa-mir-135a Lymphoma, T-Cell, Cutaneous The present study investigated the role of microRNA135a (miR135a) in cutaneous Tcell lymphoma (CTCL) proliferation. The substantially increased mRNA and protein levels of GATA3 may be associated with the downregulation of miR135a, leading to Tcell deregulation and proliferation through GATA3/TOX regulation and subsequently causing CTCL. +genetics_overexpression_promote 30747217 hsa-mir-223 Carcinoma, Non-Small-Cell Lung Meanwhile, overexpression of miRNA-223 suppressed the protein expression of EGFR, PI3K and p-Akt in NSCLC cells. +transcription factor target 30747211 hsa-mir-223 Breast Neoplasms Therefore, it was hypothesized that miR2233p may affect tumor growth and immunosuppression in breast cancer by inhibiting the NLRP3 inflammasome. Collectively these findings suggested that the inactivation of the NLRP3 inflammasome driven by miR2233p reduced the growth and immunosuppression of breast cancer in vitro and in vivo, and may represent a novel therapeutic strategy in treating breast cancer. +circulation_biomarker_diagnosis_up 30747210 hsa-mir-335 Ischemic Stroke In the MCAO rat and serumfree cell models, miR335 treatment upregulated SG formation, alleviated the ischemiainduced infarction, and decreased ROCK2 protein expression and apoptosis levels. +lncRNA target 30747209 hsa-mir-29b Adenocarcinoma of Lung Ultimately, STAT3 was identified to decrease lung adenocarcinoma cell viability, survival, apoptosis and EMT imposed by miR29b3p. +lncRNA target 30747065 hsa-mir-125b Hypoxia "The article entitled, ""MicroRNA-125b can Target p38MAPK to Resolve Intermittent Hypoxia-Induced Dementia in Murine Models"" submitted in Current Neurovascular Research (CNR) by Dr." +genetics_knock down_suppress 30746756 hsa-mir-141 Breast Neoplasms CONCLUSION: Knockdown of miR-141 causes overexpression of ERBB4, which is involved in trastuzumab resistance in breast cancer cells. This study has implications that miR-141 as well as its target, ERBB4, as a potential target for treating trastuzumab-resistant breast cancers. +genetics_overexpression_promote 30746749 hsa-mir-210 Glioblastoma Consistently, BDNF silencing had the same effects as miR-210 overexpression in glioblastoma, and upregulation of BDNF counteracted the inhibitory effect of miR-210 in glioblastoma. +other 30746254 hsa-mir-495 Pulmonary Disease, Chronic Obstructive 3p decreased marginally (P=0.058) in COPD participants. +other 30746254 hsa-mir-223 Pulmonary Disease, Chronic Obstructive 3p decreased marginally (P=0.058) in COPD participants. +other 30746254 hsa-mir-194 Pulmonary Disease, Chronic Obstructive 3p might be a potential regulator in the toxicological pathways of both PM(2.5) exposure and COPD. +virus_miRNA 30745852 ebv-mir-BART10 stomach carcinoma EBV miR-BART10-3p Promotes Cell Proliferation and Migration by Targeting DKK1 +genetics_knock down_suppress 30745844 hsa-mir-9 Leukemia, Myeloid, Acute miR-9 overexpresssion sensitized AML cells to Dnr, inhibited cell proliferation, and enhanced the ability of Dnr to induce apoptosis; miR-9 knockdown had the opposite effects. +lncRNA target 30745827 hsa-mir-155 Carcinoma, Hepatocellular Taken together, our study provided the first compelling evidence that ING4 can suppress human HCC growth and metastasis to a great extent via a NF-kappaB/miR-155/FOXO3a pathway. +exosome 30745826 hsa-mir-141 Obesity Therefore, the absorption of hepatocytes for exosomes released from obesity adipose tissue containing less miR3p than healthy adipose tissue can significantly inhibit the insulin sensitivity and glucose uptake. +lncRNA target 30745801 hsa-mir-29a Liver Cirrhosis In short, our research demonstrates that miR-29a negatively regulates HSC activation by inhibiting BRD4 and EZH2 function, thus making it a promising target for the pharmacologic treatment of hepatic fibrosis. +other 30745559 hsa-mir-184 Thyroid Neoplasms Two lncRNAs (MIR1281A2HG and OPCML-IT1) and one miRNA (miR-184) were significantly associated with OS in patients with thyroid cancer. +other 30745559 hsa-mir-1281a-2 Thyroid Neoplasms Two lncRNAs (MIR1281A2HG and OPCML-IT1) and one miRNA (miR-184) were significantly associated with OS in patients with thyroid cancer. +circulation_biomarker_diagnosis_up 30745540 hsa-mir-150 Heart Failure Serum circulating miR-150 is a novel biomarker to predict post-AMI HF. +other 30745534 hsa-mir-26a Atherosclerosis In summary, we propose that lncRNA-MEG3 modulates the proliferation/apoptosis balance of VSMCs in atherosclerosis by regulating the miR-26a/Smad1 axis. +transcription factor target 30745529 hsa-mir-223 Inflammation These data demonstrated that emodin could attenuate LPS-induced inflammatory injury and deactivate Jnk signaling pathway through down-regulation of miR-223. +lncRNA target 30745456 hsa-mir-144 Colonic Neoplasms The present study focused on the effect of miR-144 and SMAD4 on colon cancer in order to find the novel gene therapy target for the treatment of colon cancer. +circulation_biomarker_diagnosis_ns 30745282 hsa-mir-10b Pancreatic Carcinoma MicroRNAs have been proved to be the biomarker for early detection of pancreatic cancer and the precisely quantitation of the MicroRNA-10b in the blood samples even can distinguish pancreatic cancer from chronic pancreatitis (CP) and normal controls (NC). +other 30745171 hsa-mir-9a polycystic kidney disease 3 miRNA assay revealed that renal miR-9a-5p level was augmented in the SD group; we showed that this miRNA decreases ENaC channel number in CD cells. We further show that miR-9a-5p potentially implicated in this mechanism and that miR-9a-5p downregulates ENaC in cultured CD cells. +exosome 30745169 hsa-mir-486 Tuberculosis FINDINGS: Six exosomal miRNAs (miR-20a, miR-20b, miR-26a, miR-106a, miR-191, miR-486) were differentially expressed in the TB patients. +exosome 30745169 hsa-mir-20a Tuberculosis FINDINGS: Six exosomal miRNAs (miR-20a, miR-20b, miR-26a, miR-106a, miR-191, miR-486) were differentially expressed in the TB patients. +exosome 30745169 hsa-mir-106a Tuberculosis FINDINGS: Six exosomal miRNAs (miR-20a, miR-20b, miR-26a, miR-106a, miR-191, miR-486) were differentially expressed in the TB patients. +exosome 30745169 hsa-mir-191 Tuberculosis FINDINGS: Six exosomal miRNAs (miR-20a, miR-20b, miR-26a, miR-106a, miR-191, miR-486) were differentially expressed in the TB patients. +exosome 30745169 hsa-mir-20b Tuberculosis FINDINGS: Six exosomal miRNAs (miR-20a, miR-20b, miR-26a, miR-106a, miR-191, miR-486) were differentially expressed in the TB patients. +exosome 30745169 hsa-mir-26a Tuberculosis FINDINGS: Six exosomal miRNAs (miR-20a, miR-20b, miR-26a, miR-106a, miR-191, miR-486) were differentially expressed in the TB patients. +circRNA target 30745107 hsa-mir-153 Glioma Together, our study suggests that circ-0014359 promotes glioma progression via targeting miR-153/PI3K signaling pathway. +circulation_biomarker_diagnosis_ns 30744695 hsa-mir-103a Mesothelioma, Malignant 3p, and miR-103a-3p were analyzed in a nested case-control study using plasma samples from 17 prediagnostic mesothelioma cases and 34 matched asbestos-exposed controls without a malignant disease. +circulation_biomarker_diagnosis_ns 30744695 hsa-mir-126 Mesothelioma, Malignant 3p, and miR-103a-3p were analyzed in a nested case-control study using plasma samples from 17 prediagnostic mesothelioma cases and 34 matched asbestos-exposed controls without a malignant disease. +circulation_biomarker_diagnosis_ns 30744695 hsa-mir-132 Mesothelioma, Malignant 3p, and miR-103a-3p were analyzed in a nested case-control study using plasma samples from 17 prediagnostic mesothelioma cases and 34 matched asbestos-exposed controls without a malignant disease. +circRNA target 30744636 hsa-mir-375 Triple Negative Breast Neoplasms CONCLUSIONS: The circKIF4A-miRKIF4A axis regulates TNBC progression via the competitive endogenous RNA (ceRNA) mechanism. +lncRNA target 30744607 hsa-mir-193a Pulmonary Fibrosis Ligustrazin blocked PI3K/Akt/mTOR and Hh signalling as well as reduced oxidative stress via increasing miR-193a expression and autophagy, all of which reduced pulmonary fibrosis. +lncRNA target 30744607 hsa-mir-193 Pulmonary Fibrosis Ligustrazin blocked PI3K/Akt/mTOR and Hh signalling as well as reduced oxidative stress via increasing miR-193a expression and autophagy, all of which reduced pulmonary fibrosis. +other 30744585 hsa-mir-200c Lung Diseases miR-200c be a potential biomarkers for various lung diseases. +other 30743997 hsa-mir-376c Multiple Sclerosis Increased expression of miR-431, miR3p, miR-379, miR-376c, miR-381, miR-410 and miR-656 was again demonstrated in male (p(ad)(j) < 0.05), but not in female RRMS patients. +other 30743997 hsa-mir-379 Multiple Sclerosis Increased expression of miR-431, miR3p, miR-379, miR-376c, miR-381, miR-410 and miR-656 was again demonstrated in male (p(ad)(j) < 0.05), but not in female RRMS patients. +other 30743997 hsa-mir-431 Multiple Sclerosis Increased expression of miR-431, miR3p, miR-379, miR-376c, miR-381, miR-410 and miR-656 was again demonstrated in male (p(ad)(j) < 0.05), but not in female RRMS patients. +other 30743997 hsa-mir-381 Multiple Sclerosis Increased expression of miR-431, miR3p, miR-379, miR-376c, miR-381, miR-410 and miR-656 was again demonstrated in male (p(ad)(j) < 0.05), but not in female RRMS patients. +other 30743997 hsa-mir-127 Multiple Sclerosis Increased expression of miR-431, miR3p, miR-379, miR-376c, miR-381, miR-410 and miR-656 was again demonstrated in male (p(ad)(j) < 0.05), but not in female RRMS patients. +circulation_biomarker_diagnosis_ns 30743214 hsa-mir-205 Breast Neoplasms The clinical applicability of Bcl-w and miR5p from cells or animal models was confirmed using tissues and plasma of breast carcinoma patients. +other 30743213 hsa-mir-105 Myocardial Ischemia Taken together, miR-105 may constitute a new therapeutic strategy for cardioprotection in ischemic heart disease. +lncRNA target 30742923 hsa-mir-29b Osteochondritis Dissecans These data suggest that miR-29b inhibits OGD-activated microglia-induced neuronal apoptosis via inducing SOCS-1 expression, blocking JNK2/STAT3 signaling, and inhibiting IL-1beta production. +other 30742779 hsa-mir-29 Inflammation We discovered that, in addition to modulating GR function under physiologic conditions, pharmacologic glucocorticoid application in inflammatory disease also induced miR-29a expression, correlating with reduced GR levels. +other 30742779 hsa-mir-29a Inflammation We discovered that, in addition to modulating GR function under physiologic conditions, pharmacologic glucocorticoid application in inflammatory disease also induced miR-29a expression, correlating with reduced GR levels. +lncRNA target 30742067 hsa-mir-145 Stomach Neoplasms Mechanically, transforming growth factor beta1 (TGF-beta1) secretion by MSCs activated SMAD2/3 through TGF-beta receptors and induced long non-coding RNA (lncRNA) MACC1-AS1 expression in GC cells, which promoted FAO-dependent stemness and chemoresistance through antagonizing miR5p. +lncRNA target 30741544 hsa-mir-155 Colorectal Neoplasms Further mechanism research reveals that treatment of colorectal cancer (CRC) with 50 muM EGCG inhibits GRP78 expression, activates the NF-kappaB (2.55 /- 0.05-fold for HCT-116 and 2.27 /- 0.08-fold for DLD1) pathway, and enhances miR +lncRNA target 30741461 hsa-mir-130a Esophageal Neoplasms The TGF-/miR-130a-3p/SMAD4 pathway could be potential targets for clinical treatment of ESCC. +lncRNA target 30741415 hsa-mir-142 Breast Neoplasms 3p expression, for example, via miRNA replacement therapy, may represent an effective strategy for the treatment of ER-positive breast cancer patients. +lncRNA target 30741252 hsa-mir-205 Prostatic Neoplasms 3p and cell apoptosis in prostate carcinoma tissue and the LNCaP human prostate adenocarcinoma cell line by directly targeting the BCL2 gene and Bcl-2 protein expression. +lncRNA target 30741252 hsa-mir-338 Prostatic Neoplasms 3p and cell apoptosis in prostate carcinoma tissue and the LNCaP human prostate adenocarcinoma cell line by directly targeting the BCL2 gene and Bcl-2 protein expression. +genetics_overexpression_promote 30740678 hsa-mir-206 Neuralgia Subsequently, it was demonstrated that upregulation of miR-206 rescued the neuropathic pain triggered by ZEB2 overexpression in vivo through neuroinflammation inhibition. +exosome 30739785 hsa-let-7 Atherosclerosis Our study demonstrates that MSCs-exosomes ameliorated atherosclerosis in ApoE(-/-) and promoted M2 macrophage polarization in the plaque through miR-let7/HMGA2/NF-kappaB pathway. +lncRNA target 30739523 hsa-mir-765 Pancreatic Carcinoma 3p from targeting RUNX2. +circulation_biomarker_diagnosis_ns 30739283 hsa-mir-133a Carcinoma, Hepatocellular Furthermore, a miRNA array analysis using blood serum showed that treatment with YKS restored the levels of miR-133a-3p/133b-3p, miR-1a-3p and miR3p following LLC implantation to normal levels. +circulation_biomarker_diagnosis_ns 30739283 hsa-mir-342 Carcinoma, Hepatocellular Furthermore, a miRNA array analysis using blood serum showed that treatment with YKS restored the levels of miR-133a-3p/133b-3p, miR-1a-3p and miR3p following LLC implantation to normal levels. +circulation_biomarker_diagnosis_ns 30739283 hsa-mir-1a Carcinoma, Hepatocellular Furthermore, a miRNA array analysis using blood serum showed that treatment with YKS restored the levels of miR-133a-3p/133b-3p, miR-1a-3p and miR3p following LLC implantation to normal levels. +other 30738894 hsa-mir-1224 Hypertension Interestingly, Sp1/Egr1/CREB/miR-1224 levels correlate with MAO-B expression in rodent models of hypertension/MPTP-induced neurodegeneration, indicating their roles in governing MAO-B gene expression in these disease states. +other 30738894 hsa-mir-1224 MPTP Poisoning Interestingly, Sp1/Egr1/CREB/miR-1224 levels correlate with MAO-B expression in rodent models of hypertension/MPTP-induced neurodegeneration, indicating their roles in governing MAO-B gene expression in these disease states. +transcription factor target 30738779 hsa-mir-449 Breast Neoplasms Our study suggests that the miR-449b-5p/CREPT/Wnt/beta-catenin axis may play an important role in the pathogenesis of breast cancer and miR5p may serve as a potential therapeutic target for breast cancer. +other 30738779 hsa-mir-449b Breast Neoplasms Accumulating evidence has suggested that microRNA-449b-5p (miR-449b-5p) plays an important role in the development and progression of multiple cancers. +genetics_GWAS 30738609 hsa-mir-181a Myocardial Ischemia CONCLUSION: Fetal and neonatal nicotine exposure-mediated miR-181a overexpression plays an important role in nicotine-enhanced coronary vascular tone via epigenetic down-regulation of BK(ca) channel mechanism, which provides a potentially novel therapeutic molecular target of miR-181a/BK(ca) channels for the treatment of coronary heart ischemic disease. +circRNA target 30738578 hsa-mir-518a Glioblastoma The current study is aimed to explore the potential mechanism of circ_0074027 via miR-518a-5p and IL17RD in GBM progression. Our findings provide evidence that circ_0074027 plays an oncogenic role in GBM by regulating miR-518a-5p/IL17RD signaling. +circulation_biomarker_prognosis_up 30738460 hsa-mir-99a Myelodysplastic Syndromes There was a significant positive correlation between the expression level of miR-99a-5p and the percentage of marrow blasts (P<0.01), but the expression of miR-99a-5p did not correlate with chromosome karyotype and peripheral blood hemogram; In this study it was obtained that ST5 might participate in pathological mechanism of MDS by bioinformatic analyses and references. +genetics_knock down_promote 30738012 hsa-mir-126 Parkinson Disease Additionally, the CCK-8 assay and flow cytometric analysis indicated that the knockdown of HOTAIR and RAB3IP and the overexpression of miR +lncRNA target 30737902 hsa-mir-618 Stomach Neoplasms Next we used transwell assays to prove that miR-618 suppressed the invasion and migration capacity of GC cells. +genetics_overexpression_promote 30737360 hsa-mir-141 Squamous Cell Carcinoma of Head and Neck Expression levels of epidermal growth factor receptor (EGFR) were enhanced in tissues with low miR-141 expression but were reduced by miR-141 overexpression, and there was a significant negative correlation between EGFR and miR-141 levels in HNSCC tissues (P < 0.01). +transcription factor target 30737231 hsa-mir-200c Lung Neoplasms Preclinical experiments with crizotinib-resistant lung cancer cells showed that EMT associated with decreased expression of miR-200c and increased expression of ZEB1 caused cross-resistance to new-generation ALK inhibitors alectinib, ceritinib, and lorlatinib. +genetics_knock down_promote 30737032 hsa-mir-101 Pancreatic Carcinoma Moreover, SNHG14 knockdown and miR-101 mimics both led to attenuation of gemcitabine resistance-PDAC cell viability and promoted cell apoptosis rate, as well as the reduction of autophagy-related proteins (such as RAB5A and ATG4D). +lncRNA target 30737029 hsa-mir-1258 Osteosarcoma AKT3 axis may be a promising prognostic marker and therapeutic target for human OS. +other 30737027 hsa-mir-1179 Carcinoma, Non-Small-Cell Lung Moreover, we proved circ_0000735 could bound to miR-1179/1182 to exert its biological functions in NSCLC cells. +other 30737027 hsa-mir-1182 Carcinoma, Non-Small-Cell Lung Moreover, we proved circ_0000735 could bound to miR-1179/1182 to exert its biological functions in NSCLC cells. +genetics_overexpression_promote 30736829 hsa-mir-21 Carcinoma, Non-Small-Cell Lung PTEN, PDCD4 or RECK gene was overexpressed in A549 cells, while miR +circulation_biomarker_diagnosis_up 30736753 hsa-mir-122 Gastritis, Atrophic 5p in serum exosomes might serve as a potential biomarker for CAG diagnosis. +exosome 30736753 hsa-mir-451a Gastritis, Atrophic sRNA-seq results showed that hsa-miR3p, - 122-3p, and - 122-5p of the top 10 miRNAs (hsa-miR-148a-3p, - 122-3p, - 486-3p, -451a, - 122-5p, - 3591-3p, - 486-5p, -151a-3p, -92a-3p, -320a) were significantly upregulated in exosomes from CAG patients versus those from CNAG patients, but hsa-miR-451a, -151a-3p, and -92a-3p were significantly downregulated. +exosome 30736753 hsa-mir-591 Gastritis, Atrophic sRNA-seq results showed that hsa-miR3p, - 122-3p, and - 122-5p of the top 10 miRNAs (hsa-miR-148a-3p, - 122-3p, - 486-3p, -451a, - 122-5p, - 3591-3p, - 486-5p, -151a-3p, -92a-3p, -320a) were significantly upregulated in exosomes from CAG patients versus those from CNAG patients, but hsa-miR-451a, -151a-3p, and -92a-3p were significantly downregulated. +exosome 30736753 hsa-mir-148a Gastritis, Atrophic sRNA-seq results showed that hsa-miR3p, - 122-3p, and - 122-5p of the top 10 miRNAs (hsa-miR-148a-3p, - 122-3p, - 486-3p, -451a, - 122-5p, - 3591-3p, - 486-5p, -151a-3p, -92a-3p, -320a) were significantly upregulated in exosomes from CAG patients versus those from CNAG patients, but hsa-miR-451a, -151a-3p, and -92a-3p were significantly downregulated. +genetics_overexpression_promote 30735457 hsa-mir-148a Esophageal Neoplasms Upon overexpression of miR-148a-3p in esophageal cancer cells, proliferation and invasion were significantly suppressed, and apoptosis was promoted. +other 30735455 hsa-mir-155 Hepatitis B, Chronic CONCLUSION: Our findings suggest that miR-155 expression positively correlates with T-cell activation, especially in CHB patients, and is a potential biomarker for immune activation and disease progression in HBV infection. +lncRNA target 30735452 hsa-mir-23a Liver Cirrhosis Therefore, lncRNA GAS5/miR-23a may bring molecular targets for hepatic fibrosis therapy. +other 30735121 hsa-mir-122 Liver Diseases Restoration of miR-122 levels in hepatoma cells markedly enhanced the activation of interferons (IFNs) in response to a variety of viral nucleic acids or simulations, especially in response to hepatitis C virus RNA and poly (I:C). These findings renewed our knowledge of miR-122's function and have important implications for the treatment of hepatitis viruses. +other 30735121 hsa-mir-122 Hepatitis A These findings renewed our knowledge of miR-122's function and have important implications for the treatment of hepatitis viruses. +other 30735121 hsa-mir-122 Carcinoma, Hepatocellular Restoration of miR-122 levels in hepatoma cells markedly enhanced the activation of interferons (IFNs) in response to a variety of viral nucleic acids or simulations, especially in response to hepatitis C virus RNA and poly (I:C). +lncRNA target 30734878 hsa-mir-23b Sepsis Therefore, miR-23b improved sepsis-induced cardiomyopathy by attenuating the inflammatory response, suppressing apoptosis, and preventing NF-kappaB activation via targeted inhibition of TRAF6 and IkappakappaB. +lncRNA target 30734598 hsa-mir-25 Pancreatic Carcinoma 3p suppressed the expression of COL1A2 in cell lines and inhibited migration, invasion and proliferation of PC cells. +lncRNA target 30734471 hsa-mir-1258 Squamous Cell Carcinoma of Head and Neck Taken together, these findings demonstrated that miR-1258 may function as a tumour-suppressive micorRNA in OSCC and suggested that miR-1258 may be a potential therapeutic target for OSCC patients. +circulation_biomarker_diagnosis_ns 30734320 hsa-mir-146b Inflammatory Bowel Diseases RESULTS Serum microRNA146b-5p (miR-146b-5p) expression was 2.87- and 2.72-fold higher in patients with Crohn's disease and ulcerative colitis, respectively, than in healthy controls. +other 30734227 hsa-mir-200c Alzheimer Disease This resulted in a panel of 10 miRNAs (hsa-mir-107, hsa-mir-26b, hsa-mir-30e, hsa-mir-34a, hsa-mir-485, hsa-mir200c, hsa-mir-210, hsa-mir-146a, hsa-mir-34c, and hsa-mir-125b) hypothesised to be deregulated early in Alzheimer's disease, nearly 20 years before the onset of clinical symptoms. +other 30734227 hsa-mir-485 Alzheimer Disease This resulted in a panel of 10 miRNAs (hsa-mir-107, hsa-mir-26b, hsa-mir-30e, hsa-mir-34a, hsa-mir-485, hsa-mir200c, hsa-mir-210, hsa-mir-146a, hsa-mir-34c, and hsa-mir-125b) hypothesised to be deregulated early in Alzheimer's disease, nearly 20 years before the onset of clinical symptoms. +other 30734227 hsa-mir-34c Alzheimer Disease This resulted in a panel of 10 miRNAs (hsa-mir-107, hsa-mir-26b, hsa-mir-30e, hsa-mir-34a, hsa-mir-485, hsa-mir200c, hsa-mir-210, hsa-mir-146a, hsa-mir-34c, and hsa-mir-125b) hypothesised to be deregulated early in Alzheimer's disease, nearly 20 years before the onset of clinical symptoms. +other 30734227 hsa-mir-146a Alzheimer Disease This resulted in a panel of 10 miRNAs (hsa-mir-107, hsa-mir-26b, hsa-mir-30e, hsa-mir-34a, hsa-mir-485, hsa-mir200c, hsa-mir-210, hsa-mir-146a, hsa-mir-34c, and hsa-mir-125b) hypothesised to be deregulated early in Alzheimer's disease, nearly 20 years before the onset of clinical symptoms. +other 30734227 hsa-mir-107 Alzheimer Disease This resulted in a panel of 10 miRNAs (hsa-mir-107, hsa-mir-26b, hsa-mir-30e, hsa-mir-34a, hsa-mir-485, hsa-mir200c, hsa-mir-210, hsa-mir-146a, hsa-mir-34c, and hsa-mir-125b) hypothesised to be deregulated early in Alzheimer's disease, nearly 20 years before the onset of clinical symptoms. +other 30734227 hsa-mir-34a Alzheimer Disease This resulted in a panel of 10 miRNAs (hsa-mir-107, hsa-mir-26b, hsa-mir-30e, hsa-mir-34a, hsa-mir-485, hsa-mir200c, hsa-mir-210, hsa-mir-146a, hsa-mir-34c, and hsa-mir-125b) hypothesised to be deregulated early in Alzheimer's disease, nearly 20 years before the onset of clinical symptoms. +other 30734227 hsa-mir-26b Alzheimer Disease This resulted in a panel of 10 miRNAs (hsa-mir-107, hsa-mir-26b, hsa-mir-30e, hsa-mir-34a, hsa-mir-485, hsa-mir200c, hsa-mir-210, hsa-mir-146a, hsa-mir-34c, and hsa-mir-125b) hypothesised to be deregulated early in Alzheimer's disease, nearly 20 years before the onset of clinical symptoms. +other 30734227 hsa-mir-125b Alzheimer Disease This resulted in a panel of 10 miRNAs (hsa-mir-107, hsa-mir-26b, hsa-mir-30e, hsa-mir-34a, hsa-mir-485, hsa-mir200c, hsa-mir-210, hsa-mir-146a, hsa-mir-34c, and hsa-mir-125b) hypothesised to be deregulated early in Alzheimer's disease, nearly 20 years before the onset of clinical symptoms. +other 30734227 hsa-mir-210 Alzheimer Disease This resulted in a panel of 10 miRNAs (hsa-mir-107, hsa-mir-26b, hsa-mir-30e, hsa-mir-34a, hsa-mir-485, hsa-mir200c, hsa-mir-210, hsa-mir-146a, hsa-mir-34c, and hsa-mir-125b) hypothesised to be deregulated early in Alzheimer's disease, nearly 20 years before the onset of clinical symptoms. +other 30734202 hsa-mir-544a Lung Neoplasms Quantitative real-time PCR (qRT-PCR) and western blot assays showed that LEF1-AS1 was upregulated while miR-544a was downregulated in lung cancer specimens and cells. Therefore, the LEF1-AS1/miR-544a/FOXP1 axis is an important contributor to lung cancer progression. +lncRNA target 30734057 hsa-mir-490 Atherosclerosis 3p targeting Aurora kinase A (AURKA), on migration and proliferation of endothelial cells and vascular smooth muscle cells (VSMCs) during atherosclerosis. +lncRNA target 30733959 hsa-mir-135b Carcinoma, Hepatocellular Functionally, GAS5 suppresses while miR-135b promotes HCC cell invasion capacities in vitro. +lncRNA target 30733855 hsa-mir-150 Breast Neoplasms 5p targeting CCR2 in breast cancer cells. +genetics_GWAS 30733684 hsa-let-7a Carcinoma, Hepatocellular In conclusion, this study suggests that DNA hypermethylation leads to epigenetic repression of miR-let-7a in HCC cells, which induces the oncogenic IGF-signaling pathway. +other 30733646 hsa-mir-646 Stomach Neoplasms CONCLUSIONS: Our study indicated a novel regulatory loop that hsa_circ_0081143/miR-646/CDK6 axis in GC progression. +other 30733645 hsa-mir-21 Gastric Intestinal Metaplasia CONCLUSIONS: These findings suggested that SOX2 can interfere with the transcriptional activity of CDX2 in bile acid-induced IM and that miR-21 might play a key role in this process, which shed new lights in the prevention of gastric cancer. +circulation_biomarker_diagnosis_ns 30732916 hsa-mir-551b Stomach Neoplasms Another independent cohort showed that serum miR-551b-5p could differentiate GC patients from healthy controls (HCs) with area under the curve (AUC) of 0.84 (95%CI: 0.75-0.93). CONCLUSIONS: Circulating miR-551b-5p was a novel promising biomarker for the detection of GC and exploration of the molecular mechanisms of miR-551b-5p is useful to search for new therapeutic strategies of GC. +transcription factor target 30732676 hsa-mir-150 Adenocarcinoma of Lung Taken together, these results suggest that miR-150/NOTCH3/COL1A1 axis contributed to EGFR-TKI resistance in LUAD, which provide a potential therapeutic target for LUAD treatment. +genetics_GWAS 30732186 hsa-mir-146a psoriasis 1 The rs2910164 single nucleotide polymorphism (SNP) in miR-146a has been implicated in the etiology of psoriasis in different relevant studies with contradictory conclusions and limited sample size. +transcription factor target 30731284 hsa-mir-489 Atherosclerosis Dual inhibition of miR-92a-3p and miR3p in Apoe(-/-);5/6Nx with a single injection of HDL LNA inhibitors significantly reduced atherosclerotic lesion area by 28.6% compared to HDL LNA scramble (LNA-Scr) controls. +transcription factor target 30731284 hsa-mir-92a Atherosclerosis Dual inhibition of miR-92a-3p and miR3p in Apoe(-/-);5/6Nx with a single injection of HDL LNA inhibitors significantly reduced atherosclerotic lesion area by 28.6% compared to HDL LNA scramble (LNA-Scr) controls. +lncRNA target 30731134 hsa-mir-486 Leukemia 5p may inhibit the proliferation of leukemia cells and induce apoptosis through targeting FOXO1. +circulation_biomarker_diagnosis_ns 30730892 hsa-mir-548ac Multiple Sclerosis Additionally, CD58 transcripts and mature hsa-miR-548ac molecules were measured using real-time PCR in peripheral blood samples of 32 MS patients. Across different global populations and data sets, carriers of the MS risk allele showed reduced CD58 mRNA levels but increased hsa-miR-548ac levels. +genetics_overexpression_suppress 30730081 hsa-mir-421 Breast Neoplasms Further, rescue experiments suggested that miR-421 overexpression partly abrogated the oncogenic role of HOXD-AS1 in BCa cells. +circulation_biomarker_diagnosis_ns 30729703 hsa-mir-214 ankylosing spondylitis 1 Finally, lower expression of serum miR-214 was confirmed in AS after validation by qPCR. +lncRNA target 30729676 hsa-mir-802 Nephrotic Syndrome It is a possible useful clinical approach of treating miR-802 inhibitor to combat nephropathy. +lncRNA target 30729676 hsa-mir-802 Obesity It is a possible useful clinical approach of treating miR-802 inhibitor to combat nephropathy. +transcription factor target 30729664 hsa-mir-23b Fibrosis This study aimed to investigate the role of the clustered miR-23b-3p and miR-27b-3p in atrial fibrosis. Taken together, these results suggest that the clustered miR-23b-3p and miR-27b-3p consistently promote atrial fibrosis by targeting TGFBR3 to activate Smad3 signalling in HAFs, suggesting that miR-23b-3p and miR-27b-3p are potential therapeutic targets for atrial fibrosis. +transcription factor target 30729664 hsa-mir-27b Fibrosis This study aimed to investigate the role of the clustered miR-23b-3p and miR-27b-3p in atrial fibrosis. Taken together, these results suggest that the clustered miR-23b-3p and miR-27b-3p consistently promote atrial fibrosis by targeting TGFBR3 to activate Smad3 signalling in HAFs, suggesting that miR-23b-3p and miR-27b-3p are potential therapeutic targets for atrial fibrosis. +genetics_overexpression_promote 30729664 hsa-mir-27b Atrial Fibrillation Additionally, overexpression of TGFBR3 could alleviate the increase of COL1A1, COL3A1 and ACTA2 in HAFs after transfection with miR-23b-3p and miR-27b-3p respectively. +genetics_overexpression_promote 30729664 hsa-mir-27b Hyalinosis, Systemic Additionally, overexpression of TGFBR3 could alleviate the increase of COL1A1, COL3A1 and ACTA2 in HAFs after transfection with miR-23b-3p and miR-27b-3p respectively. +genetics_overexpression_promote 30729664 hsa-mir-23b Hyalinosis, Systemic Additionally, overexpression of TGFBR3 could alleviate the increase of COL1A1, COL3A1 and ACTA2 in HAFs after transfection with miR-23b-3p and miR-27b-3p respectively. +genetics_overexpression_promote 30729664 hsa-mir-23b Atrial Fibrillation Additionally, overexpression of TGFBR3 could alleviate the increase of COL1A1, COL3A1 and ACTA2 in HAFs after transfection with miR-23b-3p and miR-27b-3p respectively. +circulation_biomarker_prognosis_ns 30728923 hsa-mir-181a Rectal Neoplasms Of these, low plasma levels of exosomal miR5p and miR-181a-5p were associated with organ-invasive primary tumour (p = 0.029) and lymph node metastases (p = 0.024), respectively, both attributes of adverse LARC prognosis. +transcription factor target 30728776 hsa-mir-140 Temporomandibular Joint Disorders 5p may play a role in regulating mandibular condylar cartilage homeostasis and potentially serve as a novel prognostic factor of TMJ-OA-like pathology. +genetics_overexpression_promote 30728670 hsa-mir-21 Breast Neoplasms Significant overexpression of miRNA-21 was found in breast cancer group. +exosome 30728448 hsa-mir-375 Glioma We conclude that exosomal miR-375 from hMSCs inhibits glioma cell progression through SLC31A1 suppression, and ultimately serves as a potential target in the treatment of gliomas. +other 30728437 hsa-mir-150 Squamous Intraepithelial Lesions Our aim was to evaluate the expression of miR-16, miR-20a, miR-150 and miR-155 in several grades of ASIL obtained from high-risk patients, submitted to anal cancer screening from July 2016 to January 2017. +other 30728437 hsa-mir-20a Squamous Intraepithelial Lesions Our aim was to evaluate the expression of miR-16, miR-20a, miR-150 and miR-155 in several grades of ASIL obtained from high-risk patients, submitted to anal cancer screening from July 2016 to January 2017. +other 30728437 hsa-mir-155 Squamous Intraepithelial Lesions Although non- significant, there was an increasing trend in the miR-155 fold expression from negative samples to HSIL, with the highest fold expression increase in both LSIL and HSIL compared to the other miRNAs. +other 30728437 hsa-mir-16 Squamous Intraepithelial Lesions Our aim was to evaluate the expression of miR-16, miR-20a, miR-150 and miR-155 in several grades of ASIL obtained from high-risk patients, submitted to anal cancer screening from July 2016 to January 2017. +genetics_knock down_promote 30728365 hsa-mir-148a Carcinoma, Hepatocellular Functional analysis demonstrated post-transcriptional regulation of TFR1 by miR-148a in HCC cells as well as decreased HCC cell proliferation upon either miR-148a overexpression or TFR1 knockdown. +other 30728149 hsa-mir-24 Prostatic Neoplasms 3p/miR-30c-5p). +other 30728149 hsa-mir-222 Prostatic Neoplasms 3p/miR-30c-5p). +circRNA target 30728056 hsa-mir-767 Multiple Myeloma Moreover, circ_0000190 inhibited cell viability, proliferation and induced apoptosis of MM thus inhibiting cell progression, which is partially through the negative regulation of miR +other 30728054 hsa-mir-376b Glioma 5p/miR-376b-3p- FOXP2- KDM5B feedback loop plays a pivotal role in regulating the malignant behavior of glioma cells. +other 30728054 hsa-mir-154 Glioma 5p/miR-376b-3p- FOXP2- KDM5B feedback loop plays a pivotal role in regulating the malignant behavior of glioma cells. +genetics_knock down_promote 30728051 hsa-mir-7 Stomach Neoplasms CONCLUSIONS: Our data suggest loss of miR-7 in GC promotes p65-mediated aberrant NF-kappaB activation, facilitating GC metastasis and ultimately resulting in the worse clinical outcome. +lncRNA target 30728036 hsa-mir-188 Pancreatic Carcinoma Rescue experiments showed that LINC00346 attenuated the growth-suppressing and chemosensitizing effects of miR +other 30727918 hsa-mir-548as Carcinoma, Non-Small-Cell Lung We further showed that miR-548as-3p increased invasiveness of NSCLC cells and was upregulated in metastatic tumor tissues compared to non-metastatic ones. CONCLUSION: All these findings provide a miRNAs-mediated novel mechanism for NF-kappaB signaling and that miR-548as-3p could be a biomarker for NSCLC metastasis. +other 30727807 hsa-mir-21 Stomach Neoplasms Curcumin regulates the miR-21/PTEN/Akt pathway and acts in synergy with PD98059 to induce apoptosis of human gastric cancer MGC-803 cells. +lncRNA target 30726934 hsa-mir-708 Breast Neoplasms However, the regulatory functions of GCs on miR-708 and its downstream target genes in human breast cancer cells (BCCs) are poorly understood. Overall, our data strongly suggest that GR agonists induced miR-708 and downstream suppression of NF-kappaB signaling, which may be applicable as a novel therapeutic intervention in breast cancer treatment. +lncRNA target 30726150 hsa-mir-340 Osteosarcoma In addition, SNHG16 reduced miR-340 expression in OS cells. The results showed that SNHG16 involves in the migration and invasion of OS cells through sponging miRNA-340. +other 30726113 hsa-mir-135a Meningitis, Bacterial Taken together, the key findings of the current study present evidence suggesting that miR-135a can downregulate HIF-1alpha and play a contributory role in the development of astrocytes derived from BM, providing a novel theoretical perspective for BM treatment approaches. +other 30726072 hsa-mir-515 Triple Negative Breast Neoplasms These results were confirmed in two other cell lines that express miR-515 and are HER2-, the hepatocellular carcinoma cell line HepG2 and the TNBC line MDA-MB-231. +other 30725211 hsa-let-7 Inflammation CONCLUSION These results demonstrate that HT-3Os blunts pathological EndMT in inflamed EC, maintaining high let-7 miRNA expression and preventing activation of TGF- signalling. +transcription factor target 30724771 hsa-mir-29a Uterine Cervical Neoplasms MiR-29a inhibited cell proliferation, migration, and invasion, as well as promoted cell apoptosis through repressing the PAK1/LIMK signaling pathway by targeting CDC42 in cervical cancer. +other 30724444 hsa-let-7i Coronary Aneurysm As a biomarker candidate, let-7i-3p provides an additional means of diagnosing CAA patients. +other 30724444 hsa-let-7i Mucocutaneous Lymph Node Syndrome As a biomarker candidate, let-7i-3p provides an additional means of diagnosing CAA patients. +genetics_knock down_promote 30723916 hsa-mir-494 Melanoma Functional studies revealed that knockdown of rab27a and subsequent accumulation of miR-494 significantly suppressed the malignant phenotypes of melanoma cells via inducing cell apoptosis. +lncRNA target 30723269 hsa-mir-146b Urinary Bladder Neoplasms In summary, the circINTS4/miR-146b/CARMA3 axis might serve as a promising therapeutic target for BC intervention. +epigenetics 30723051 hsa-mir-133b Carcinoma, Hepatocellular TONSL was predictively targeted by miR-133b, which was downregulated in HCC and negatively related to TONSL mRNA expression (all P<0.05). DNA amplification, hypomethylation and miR-133b downregulation could be the mechanisms associated with TONSL upregulation in HCC. +lncRNA target 30721952 hsa-mir-145 Pituitary Neoplasms 5p to regulate the TPT1 signaling pathway, revealing a therapeutic target in preventing the tumorigenesis of NFPAs. +genetics_GWAS 30721753 hsa-mir-146a Diabetic Neuropathies We demonstrated that nano-miR-146a-5p improved nerve conduction velocity and alleviated the morphological damage and demyelination of the sciatic nerve of DPN rats. +transcription factor target 30721745 hsa-mir-185 Osteosarcoma Therefore, these results confirm that decreased expression of miR-185 might be regarded as a tumor marker for the early diagnosis of OS, by manipulating of its interactive factors with VAMP2, to provide an effective novel therapeutic target for treatment of the OS tumor. +other 30721395 hsa-mir-132 Opioid-Related Disorders These findings indicate that miR-132 is involved in opioid addiction, probably by promoting the differentiation of NSCs in the adult DG. +other 30720865 hsa-let-7 Breast Neoplasms Here, we identified a novel lncRNA whose expression is high in breast cancer and especially higher in luminal breast cancer, dubbed LOL (lncRNA of luminal), that acts as a natural sponge for let-7 microRNAs to regulate tumor growth and tamoxifen resistance. +lncRNA target 30720809 hsa-mir-34a Stomach Neoplasms Further, an anti-proliferative effect could be obtained after PPP/miR-34a transfection through the induction of cell apoptosis. +genetics_overexpression_promote 30720199 hsa-mir-217 Carcinoma, Non-Small-Cell Lung DACH1 reverses the effects of miR-217 overexpression in NSCLC cells. +other 30720190 hsa-mir-154 Myocardial Infarction, Acute OBJECTIVE: To explore the influence of micro ribonucleic acid (miR)-154 on myocardial apoptosis in rats with acute myocardial infarction (AMI), and to analyze whether Wnt/beta-catenin signaling pathway was involved in the regulation. CONCLUSIONS: AMI significantly increases the expression level of miR-154. +lncRNA target 30720182 hsa-mir-196a Hypoxia-Ischemia, Brain This study was designed to investigate the functional behaviors and regulatory mechanisms of miR-196a in ischemic brain injury. CONCLUSIONS: These findings indicated a crucial role of miR-196a in regulating infarct volume and neuronal cell death under cerebral ischemia, thus offering a new target for the development of therapeutic agents against ischemic brain injury. +lncRNA target 30720181 hsa-mir-153 Ischemic Stroke CONCLUSIONS: The up-regulation of miR-153 rats activated the Shh signaling pathway to promote angiogenesis and improve prognosis through lipid-coated Patch (PTC) in MCAO. +lncRNA target 30720180 hsa-mir-599 Parkinson Disease MicroRNA-599 inhibits the development of PD through regulating the LRRK2 expression. +transcription factor target 30720179 hsa-mir-144 Neuroblastoma CONCLUSIONS: Taken together, these results demonstrated the tumor suppressive role of miR +lncRNA target 30720178 hsa-mir-19 Breast Neoplasms The results of Luciferase reporter assays indicated that TUBA4B directly targeted miR-19, which could rescue the effects of TUBA4B on breast cancer cells. CONCLUSIONS: It is suggested that TUBA4B was downregulated in breast cancer and suppressed proliferation and invasion of breast cancer by targeting miR-19. +lncRNA target 30720177 hsa-mir-431 Lung Neoplasms MiR-431 suppressed proliferation, invasion and migration of lung cancer cells via inhibiting the expression of DDX5. +lncRNA target 30720176 hsa-mir-107 Lung Neoplasms Therefore, it is suggested that lncRNA FOXC2-AC1 may promote malignant progression of LCa through the mutual regulation of miR-107. +lncRNA target 30720175 hsa-mir-126 Carcinoma, Non-Small-Cell Lung 3p suppressed NSCLC cell growth and lung metastasis by targeting chemokine (C-C motif) receptor 1 (CCR1). +genetics_knock down_promote 30720172 hsa-mir-625 Squamous Cell Carcinoma of Head and Neck 3p promoted migration of OSCC cells, which was reversed by SCAI knockdown. +genetics_overexpression_promote 30720171 hsa-mir-127 Squamous Cell Carcinoma of Head and Neck Functionally, overexpression of miR +transcription factor target 30720170 hsa-mir-122 Nasopharyngeal Carcinoma 5p functions as a tumor suppressor and may be a therapeutic target for NPC. +genetics_knock down_promote 30720165 hsa-mir-10b Colorectal Neoplasms Finally, the knockdown of FGF13 was able to mimic the inhibitory effects of miR-10b on the progression of CRC cells. +genetics_knock down_promote 30720164 hsa-mir-637 Carcinoma, Hepatocellular Results of dual-luciferase reporting assay and Western blot demonstrated that miR-637 can selectively degrade AKT1 and that overexpression of AKT1 in HCC cells can partially reverse the effect of miR-637 on cell proliferation and invasion. +circRNA target 30720163 hsa-mir-620 Carcinoma, Hepatocellular CONCLUSIONS: Hsa_circ_103809 acts by binding to miR-620 and inhibiting the tumourigenicity of HCC. +genetics_overexpression_promote 30720162 hsa-mir-425 Prostatic Neoplasms Importantly, we found overexpression of miR +lncRNA target 30720161 hsa-mir-490 Prostatic Neoplasms 3p functioned as a tumor-suppressive role in PCa progression. +lncRNA target 30720160 hsa-mir-1299 Prostatic Neoplasms CONCLUSIONS: Our study indicated that miR-1299 was a novel suppressor in PCa through its negative regulation of NEK2. +transcription factor target 30720158 hsa-mir-374b Uterine Cervical Neoplasms CONCLUSIONS: These results indicated that miR-374b acted as tumor suppressor and may serve as a potential target for cervical cancer treatment. +lncRNA target 30720155 hsa-mir-203a Uterine Cervical Neoplasms Moreover, FOXN2 was identified as a direct target gene of miR-203a-5p, and the up-regulation of miR-203a-5p reversed the inhibitory effects of WT1-AS in cervical cancer cells. +circulation_biomarker_diagnosis_ns 30720151 hsa-mir-9 Osteoporosis 5p is lowly expressed in the peripheral blood of OS patients. +transcription factor target 30720150 hsa-mir-214 Osteoporotic Fractures CONCLUSIONS: MiR3p delays fracture healing in rats with osteoporotic fracture by inhibiting the BMP/Smad signaling pathway. +lncRNA target 30720148 hsa-mir-21 Spinal Cord Injuries After that, we injected SCI rat with miR-21 inhibitor into the spinal cord injury area and found the inhibition of miR-21 decreased the protein levels of iNOS and TNF-alpha. +lncRNA target 30720136 hsa-mir-29c Melanoma Furthermore, it was observed that miR29c3p could reverse the promoting effect of TUG1 on melanoma progression, which may be associated with the positive regulation of regulator of G-protein signaling 1 (RGS1), a target gene of miR29c3p. Taken together, the data of the present study demonstrated that TUG1 promoted proliferation and invasion and suppressed apoptosis in melanoma cells by regulating miR29c3p and its target gene, RGS1. +lncRNA target 30720134 hsa-mir-200 Pancreatic Carcinoma The inhibitory effects of TCRV on pancreatic cancer cell migration and invasion were counteracted by antimiR200 family members. +genetics_overexpression_promote 30720118 hsa-mir-663b Carcinoma, Hepatocellular GAB2 overexpression was able to rescue the suppressive effects of miR663b on HCC cells. +lncRNA target 30720115 hsa-mir-155 dystonia 5 The present study aimed to investigate the roles and mechanisms of miR155 in treatmentresistant depression (TRD). The potential effects of miR155 on the activation of microglial cells suggest that miR155 may be an effective target for TRD therapies. +other 30720115 hsa-mir-155 Neurotic Disorders The present study aimed to investigate the roles and mechanisms of miR155 in treatmentresistant depression (TRD). +lncRNA target 30720115 hsa-mir-155 Inflammation The results revealed that miR155 reduced the cell viability of BV2 microglial cells, and miR155 enhanced the expression levels of proinflammatory cytokines in BV2 microglial cells. In conclusion, the present results suggested that miR155 mediated the inflammatory injury in hippocampal neuronal cells by activating the microglial cells. +lncRNA target 30720112 hsa-mir-194 Hypopharyngeal Neoplasms These data suggested that miR1945ptargeted SMURF1 inhibition may be involved in the disruption of HPC progression through the repression of the mTOR signaling pathway. +other 30720099 hsa-mir-23b Cicatrix Reverse transcriptionquantitative polymerase chain reactions were performed on six traumatic scar samples and matched normal skin samples; traumatic scar formation was revealed to be significantly inversely associated with miR23b3p expression. +epigenetics 30720097 hsa-mir-148a Leukemia, Myeloid, Acute In AML cell lines, the methylation state of miR148 promoter was significantly increased compared with normal cells. +transcription factor target 30720092 hsa-mir-491 Uterine Cervical Neoplasms Transfection experiments indicated that the role of JMJD2A in cervical cancer was mediated, at least in part, by the repression of miR4915p. In summary, JMJD2A was identified as an oncogenic protein in human cervical cancer that significantly affected cell and colony numbers, tumor weight and apoptosis via the downregulation of miR4915p, which acts as a tumor suppressor in cervical cancer. +genetics_overexpression_promote 30720088 hsa-mir-504 Retinoblastoma Additionally, the tumorsuppressing effects of miR504 overexpression in RB cells could be rescued by AEG1 upregulation. +genetics_overexpression_promote 30720072 hsa-mir-124 Spinal Cord Injuries The present results demonstrated that overexpression of miR124 by agomir124 improves functional recovery, decreases lesion size and suppresses neuronal cell apoptosis in a rat SCI model. +lncRNA target 30720061 hsa-mir-766 Pulmonary Fibrosis The integrated analysis of mRNA and miRNA expression data, combined with GEO verification, finally identified Homo sapiens (hsa)miR1254INKA2 and hsamiR7663pINKA2 as the potential miRNAmRNA interactions in IPF fibroblasts. In summary, the results of the present study suggest that dysregulation of PAX8, hsamiR1254INKA2 and hsamiR7663pINKA2 may promote the proliferation and survival of IPF fibroblasts. +lncRNA target 30720059 hsa-mir-199a Squamous Cell Carcinoma of Head and Neck These findings indicate that miR199a5p functions as a tumor suppressor through regulation of the NFkappaB pathway by targeting IKKbeta in OSCC. +lncRNA target 30720057 hsa-mir-183 Ovarian Neoplasms In conclusion, the results of the present study suggested that miR183 exerted tumorpromoting roles in OC, at least partially by regulating Smad4 via the TGFbeta/Smad4 signaling pathway. +other 30719423 hsa-mir-574 Esophageal Squamous Cell Carcinoma 5p were identified as the powerful biomarkers for the diagnosis of ESCC. +other 30719423 hsa-mir-451a Esophageal Squamous Cell Carcinoma 5p were identified as the powerful biomarkers for the diagnosis of ESCC. +other 30719423 hsa-mir-16 Esophageal Squamous Cell Carcinoma 5p were identified as the powerful biomarkers for the diagnosis of ESCC. +transcription factor target 30719208 hsa-mir-33a Lung Neoplasms Among the miRNAs down-regulated by RASSF1C is miRNA-33a-5p (miRNA-33a), which functions as a tumor suppressor in lung cancer cells. Our findings suggest that RASSF1C may promote lung epithelial mesenchymal transition (EMT), resulting in the development of a lung cancer stem cell phenotype, progression, and metastasis, in part, through modulation of miR-33a expression. +genetics_overexpression_promote 30719151 hsa-mir-449a Endometrial Neoplasms Overexpression of miR-449a decreased the migration and invasion of KLE and AN3CA endometrial cancer cells. +lncRNA target 30719138 hsa-mir-1307 Breast Neoplasms 3p is a oncogenic miRNA that significantly contributes to breast cancer development and progression, and inhibition of miR +other 30719118 hsa-mir-16 Pituitary Neoplasms In the present study, it was investigated whether miR-16 may regulate the expression of HMGA2 and whether it is involved in the pathogenesis of PAs. The downregulation of miR-16 and upregulation of HMGA2 were involved in the pathogenesis of PAs. +genetics_overexpression_promote 30719113 hsa-mir-372 Carcinoma, Renal Cell Notably, ATAD2 silence exerted suppressive functions in RCC cells, being similar to the effects of miR-372 overexpression. +lncRNA target 30718600 hsa-mir-212 Kidney Failure, Chronic MicroRNA-212 (miR-212) has been demonstrated previously to be a crucial regulator of pathologic LVH in pressure-overload-induced heart failure via regulating the forkhead box O3 (FOXO3)/calcineurin/nuclear factor of activated T-cells (NFAT) pathway. +circulation_biomarker_diagnosis_ns 30718561 hsa-mir-572 Instent Restenosis We found that differential circulating microRNA expression in patients after stenting with ISR, and the data indicate that circulating microRNA-320a and microRNA-572 have promising value in diagnosing ISR in patients with LEAOD. +circulation_biomarker_diagnosis_ns 30718561 hsa-mir-20a Arterial Occlusive Diseases We found that differential circulating microRNA expression in patients after stenting with ISR, and the data indicate that circulating microRNA-320a and microRNA-572 have promising value in diagnosing ISR in patients with LEAOD. +circulation_biomarker_diagnosis_ns 30718561 hsa-mir-20a Instent Restenosis We found that differential circulating microRNA expression in patients after stenting with ISR, and the data indicate that circulating microRNA-320a and microRNA-572 have promising value in diagnosing ISR in patients with LEAOD. +circulation_biomarker_diagnosis_ns 30718561 hsa-mir-572 Arterial Occlusive Diseases We found that differential circulating microRNA expression in patients after stenting with ISR, and the data indicate that circulating microRNA-320a and microRNA-572 have promising value in diagnosing ISR in patients with LEAOD. +genetics_overexpression_promote 30718452 hsa-mir-29c Carcinoma, Hepatocellular Overexpression of miR-29c-3p significantly inhibited HCC cell proliferation, apoptosis, migration, and tumor growth in vivo. +lncRNA target 30718276 hsa-mir-141 Nasopharyngeal Carcinoma Furthermore, restoring miR-141 expression could at least partially reverse the inhibitory effect of YY1 on cell proliferation and tumor growth and on the expression of some critical c-Myc targets, such as PTEN/AKT pathway components both in vitro and in vivo We also found that YY1 expression is reduced in NPC tissues, negatively correlates with miR-141 expression and clinical stages in NPC patients, and positively correlates with survival prognosis. Our results reveal a previously unappreciated mechanism in which the YY1/c-Myc/miR-141 axis plays a critical role in NPC progression and may provide some potential and valuable targets for the diagnosis and treatment of NPC. +transcription factor target 30718101 hsa-mir-222 Polycystic Ovary Syndrome In conclusion, our findings suggested that miR-222 may promote the progression of PCOS by targeting p27 Kip1. +other 30718039 hsa-mir-26a Parkinson Disease CONCLUSIONS miR-26a/DAPK1 signaling cascades are essential in the formation of the molecular and cellular pathologies in PD. +lncRNA target 30717973 hsa-mir-106b Carcinoma, Renal Cell Thus, XIST positively regulated the expression of P21 through sponging miR-106b-5p, and played a tumor suppressor role in RCC. Moreover, we found that curcumin could regulate XIST/miR-106b-5p/P21 axis in RCC cells. +other 30717752 hsa-mir-205 Prostatic Neoplasms These findings support the clinical interest in developing a novel therapeutic approach based on miR-205 reconstitution to increase PCa response to radiotherapy. +genetics_overexpression_promote 30717751 hsa-mir-149 Stomach Neoplasms 5p inhibition phenocopied the overexpression of circNRIP1 in GC cells, and overexpression of miR +other 30717412 hsa-mir-133a Cardiovascular And Cerebrovascular Diseases 3p and miR-133a-3p) that were induced by pregnancy complications are long-acting and may predispose children affected with GH, PE, or FGR to later development of cardiovascular/cerebrovascular diseases. +other 30717412 hsa-mir-1 Cardiovascular And Cerebrovascular Diseases 3p and miR-133a-3p) that were induced by pregnancy complications are long-acting and may predispose children affected with GH, PE, or FGR to later development of cardiovascular/cerebrovascular diseases. +other 30717317 hsa-mir-122 Carcinoma, Hepatocellular MiR-122 replacement therapy in combination with sorafenib deserves attention as a possible therapeutic strategy in SerpinB3-negative HCCs. +other 30717310 hsa-mir-17 Platelet Storage Pool Deficiency The anti-EGFP or anti-CSFV shRNAs could be stably and effectively expressed at the control of the endogenous promoter of the pmiR92 cluster. +other 30716792 hsa-mir-486 Breast Neoplasms 3p were down-regulated in patients with breast cancer with SLN metastasis. +other 30716792 hsa-mir-1 Breast Neoplasms 3p were down-regulated in patients with breast cancer with SLN metastasis. +other 30716792 hsa-mir-96 Breast Neoplasms 3p were down-regulated in patients with breast cancer with SLN metastasis. +other 30716792 hsa-mir-200a Breast Neoplasms 3p were down-regulated in patients with breast cancer with SLN metastasis. +other 30716449 hsa-mir-338 Osteoporosis CLINICAL SIGNI fi CANCE: Understanding the role played by miR3p in osteoclast differentiation bridges the gap between the pathogenesis of osteoporosis and the quest for novel therapeutics to reduce the risk of bone fracture associated with this global disease. +lncRNA target 30716387 hsa-mir-20b Colorectal Neoplasms The present study proposes a new direction to investigate the molecular mechanisms underlying the invasion and metastasis of CRC, whereby the interaction between MALAT1 and miR-20b-5p could be a novel therapeutic target for CRC. +other 30716366 hsa-mir-9 Esophageal Squamous Cell Carcinoma Hence, this study investigated role of miR5p in the angiogenesis and apoptosis of HG-induced human umbilical vascular endothelial cells (HUVECs) injury. +lncRNA target 30716314 hsa-mir-34a Neuroblastoma Results showed that miR-34a expression was inhibited in NB tissues and cells with low survival rate. +other 30715622 hsa-mir-449a Mitochondrial Diseases * MiR-449a-5p is involved in hypoxia-induced mitochondria dysfunction of PASMCs. +other 30715622 hsa-mir-449a Hypertension, Pulmonary KEY MESSAGES: * The downregulation of miR-449a-5p occurs in both PAH-PAs and hypoxic PASMCs. +circulation_biomarker_diagnosis_ns 30715214 hsa-mir-10b Coronary Artery Disease We found miR5p plays an important role in regulating low-density lipoprotein (LDL), total cholesterol (TC), fasting glucose, HbA1c, and several lipid-metabolites in blood, whereas, miR-10b-5p mediates the trans-regulatory effect of the ABO locus on several blood proteins, coronary artery disease, and TC. +circulation_biomarker_diagnosis_ns 30715214 hsa-mir-10b Mandibulofacial Dysostosis We found miR5p plays an important role in regulating low-density lipoprotein (LDL), total cholesterol (TC), fasting glucose, HbA1c, and several lipid-metabolites in blood, whereas, miR-10b-5p mediates the trans-regulatory effect of the ABO locus on several blood proteins, coronary artery disease, and TC. +circulation_biomarker_diagnosis_ns 30715214 hsa-mir-1908 Coronary Artery Disease We found miR5p plays an important role in regulating low-density lipoprotein (LDL), total cholesterol (TC), fasting glucose, HbA1c, and several lipid-metabolites in blood, whereas, miR-10b-5p mediates the trans-regulatory effect of the ABO locus on several blood proteins, coronary artery disease, and TC. +circulation_biomarker_diagnosis_ns 30715214 hsa-mir-1908 Mandibulofacial Dysostosis We found miR5p plays an important role in regulating low-density lipoprotein (LDL), total cholesterol (TC), fasting glucose, HbA1c, and several lipid-metabolites in blood, whereas, miR-10b-5p mediates the trans-regulatory effect of the ABO locus on several blood proteins, coronary artery disease, and TC. +circulation_biomarker_diagnosis_ns 30715214 hsa-mir-199a Mandibulofacial Dysostosis Moreover, we demonstrated that a higher plasma level of miR-199a is causally associated with lower levels of LDL and TC. +other 30714722 hsa-mir-133a Myocardial Infarction These unique features endow the SNAzyme-boosted CL platform with superior imaging performance for analyzing an AMI-related miRNA, miRNA-133a. +exosome 30714442 hsa-let-7i Lymphoma, B-Cell This study aimed to investigate and compare exosomal miR-155, let-7g and let-7i levels as a noninvasive biomarker among patients with refractory/relapsed or responsive DLBCL after R-CHOP treatment and patients receiving R-CHOP. +exosome 30714442 hsa-mir-155 Lymphoma, B-Cell This study aimed to investigate and compare exosomal miR-155, let-7g and let-7i levels as a noninvasive biomarker among patients with refractory/relapsed or responsive DLBCL after R-CHOP treatment and patients receiving R-CHOP. Therefore, exosomal miR-155 might be useful as potential prognostic biomarkers to predict response to treatment in DLBCL patients. +exosome 30714442 hsa-let-7g Lymphoma, B-Cell This study aimed to investigate and compare exosomal miR-155, let-7g and let-7i levels as a noninvasive biomarker among patients with refractory/relapsed or responsive DLBCL after R-CHOP treatment and patients receiving R-CHOP. +circulation_biomarker_diagnosis_up 30714182 hsa-mir-210 Azoospermia Our results suggest that seminal plasma miR +lncRNA target 30714151 hsa-mir-371a Pancreatic Carcinoma MiR-371a-5p rescued the inhibitory effects of TUSC7 on the development of pancreatic carcinoma. We conclude that lncRNA TUSC7 suppresses pancreatic carcinoma progression by modulating miR-371a-5p expression, indicating an innovative therapeutic strategy for pancreatic carcinoma. +lncRNA target 30714138 hsa-mir-124 Interstitial Fibrosis, Renal Overall, our study demonstrates the contributory effect of lncRNA HOTAIR on RIF by activating the Notch1/Jagged1 signaling pathway via inhibition of miR-124, whereas administration of PAE can alleviate the effects of HOTAIR on RIF. +other 30714135 hsa-mir-144 Adenocarcinoma of Lung Consequently, the data of the study indicates that interference of LINC00483 weakens its competitive binding ability to miR-144, thus reducing HOXA10 expression, and enhancing radiosensitivity in LAD. +circulation_biomarker_diagnosis_up 30713578 hsa-mir-210 Diabetes Mellitus, Type 2 Our results support a functional role of circulating hypoxia responsive microRNAs: miR-424, miR-210, miR-199a, and miR-21 as potential therapeutic targets in angiogenesis and vascular remodeling in diabetic wound healing. +circulation_biomarker_diagnosis_up 30713578 hsa-mir-424 Diabetes Mellitus, Type 2 Our results support a functional role of circulating hypoxia responsive microRNAs: miR-424, miR-210, miR-199a, and miR-21 as potential therapeutic targets in angiogenesis and vascular remodeling in diabetic wound healing. +circulation_biomarker_diagnosis_up 30713578 hsa-mir-21 Diabetes Mellitus, Type 2 Our results support a functional role of circulating hypoxia responsive microRNAs: miR-424, miR-210, miR-199a, and miR-21 as potential therapeutic targets in angiogenesis and vascular remodeling in diabetic wound healing. +circulation_biomarker_diagnosis_up 30713578 hsa-mir-199a Diabetes Mellitus, Type 2 Our results support a functional role of circulating hypoxia responsive microRNAs: miR-424, miR-210, miR-199a, and miR-21 as potential therapeutic targets in angiogenesis and vascular remodeling in diabetic wound healing. +transcription factor target 30713220 hsa-mir-187 Hemangioma 3p may serve as a novel prognostic indicator and potential target for infantile hemangioma therapy.Key words: MiR +other 30713088 hsa-mir-149 Pre-Eclampsia CONCLUSIONS: Our findings highlight the importance of miR5p in the pathogenesis of preeclampsia and provide new insight into the development of the disease. +lncRNA target 30712885 hsa-mir-138 Adenocarcinoma of Lung 5p inhibitor. +other 30712556 hsa-mir-21 Breast Neoplasms Furthermore, it has been successfully applied to analyze the content of miRNA-21 in breast cancer cell. +genetics_overexpression_promote 30712321 hsa-mir-30 Pancreatic Carcinoma 3p could depress pancreatic cancer progression while overexpressed miR +other 30712246 hsa-mir-143 Precursor Cell Lymphoblastic Leukemia-Lymphoma 3p related to LSC and LP populations which have regulatory functions in stem-cell associated biological processes. +other 30712246 hsa-mir-744 Precursor Cell Lymphoblastic Leukemia-Lymphoma 3p related to LSC and LP populations which have regulatory functions in stem-cell associated biological processes. +other 30712246 hsa-mir-493 Precursor Cell Lymphoblastic Leukemia-Lymphoma 3p related to LSC and LP populations which have regulatory functions in stem-cell associated biological processes. +other 30712246 hsa-mir-10a Precursor Cell Lymphoblastic Leukemia-Lymphoma 3p related to LSC and LP populations which have regulatory functions in stem-cell associated biological processes. +other 30712246 hsa-mir-4658 Precursor Cell Lymphoblastic Leukemia-Lymphoma 3p related to LSC and LP populations which have regulatory functions in stem-cell associated biological processes. +other 30712246 hsa-mir-6503 Precursor Cell Lymphoblastic Leukemia-Lymphoma 3p related to LSC and LP populations which have regulatory functions in stem-cell associated biological processes. +genetics_overexpression_suppress 30712191 hsa-mir-370 Central Nervous System Neoplasms We first showed that miR-370 was downregulated in PCNSL tissues, while MGMT was inversely overexpressed. +other 30711956 hsa-mir-222 Inflammation Our purpose was to assess the acute response to radiation-induced modulation of the expression of miRNA-146a, miRNA-155, miRNA-221, and miRNA-222, inflammatory response and endothelial dysfunction on endothelial cells. +other 30711956 hsa-mir-155 Cardiovascular Diseases Our purpose was to assess the acute response to radiation-induced modulation of the expression of miRNA-146a, miRNA-155, miRNA-221, and miRNA-222, inflammatory response and endothelial dysfunction on endothelial cells. +other 30711956 hsa-mir-155 Inflammation Our purpose was to assess the acute response to radiation-induced modulation of the expression of miRNA-146a, miRNA-155, miRNA-221, and miRNA-222, inflammatory response and endothelial dysfunction on endothelial cells. +other 30711956 hsa-mir-146a Inflammation Our purpose was to assess the acute response to radiation-induced modulation of the expression of miRNA-146a, miRNA-155, miRNA-221, and miRNA-222, inflammatory response and endothelial dysfunction on endothelial cells. +other 30711956 hsa-mir-221 Acute Lung Injury Our purpose was to assess the acute response to radiation-induced modulation of the expression of miRNA-146a, miRNA-155, miRNA-221, and miRNA-222, inflammatory response and endothelial dysfunction on endothelial cells. +other 30711956 hsa-mir-221 Cardiovascular Diseases Our purpose was to assess the acute response to radiation-induced modulation of the expression of miRNA-146a, miRNA-155, miRNA-221, and miRNA-222, inflammatory response and endothelial dysfunction on endothelial cells. +other 30711956 hsa-mir-146a Acute Lung Injury Our purpose was to assess the acute response to radiation-induced modulation of the expression of miRNA-146a, miRNA-155, miRNA-221, and miRNA-222, inflammatory response and endothelial dysfunction on endothelial cells. +other 30711956 hsa-mir-221 Inflammation Our purpose was to assess the acute response to radiation-induced modulation of the expression of miRNA-146a, miRNA-155, miRNA-221, and miRNA-222, inflammatory response and endothelial dysfunction on endothelial cells. +other 30711956 hsa-mir-146a Cardiovascular Diseases Our purpose was to assess the acute response to radiation-induced modulation of the expression of miRNA-146a, miRNA-155, miRNA-221, and miRNA-222, inflammatory response and endothelial dysfunction on endothelial cells. +other 30711956 hsa-mir-155 Acute Lung Injury Our purpose was to assess the acute response to radiation-induced modulation of the expression of miRNA-146a, miRNA-155, miRNA-221, and miRNA-222, inflammatory response and endothelial dysfunction on endothelial cells. +other 30711956 hsa-mir-222 Acute Lung Injury Our purpose was to assess the acute response to radiation-induced modulation of the expression of miRNA-146a, miRNA-155, miRNA-221, and miRNA-222, inflammatory response and endothelial dysfunction on endothelial cells. +other 30711956 hsa-mir-222 Cardiovascular Diseases Our purpose was to assess the acute response to radiation-induced modulation of the expression of miRNA-146a, miRNA-155, miRNA-221, and miRNA-222, inflammatory response and endothelial dysfunction on endothelial cells. +other 30711939 hsa-mir-21 Carcinoma, Transitional Cell We previously reported that miR-21 in UC may be a prognostic marker for cancer progression. The aim of this study was to examine the clinicopathological significance of CD10 expression in UC and its relationship with miR-21 expression. +lncRNA target 30711930 hsa-mir-3687 Esophageal Neoplasms MATERIALS AND METHODS: miR-3687 expression in human ESCC cell lines and in primary tumour samples obtained from patients with ESCC who underwent esophagectomy were analyzed via real-time polymerase chain reaction (PCR). +genetics_overexpression_suppress 30711634 hsa-mir-146a Liver Cirrhosis Therefore, the present study aimed to evaluate the effect of miR-146a on the EMT of hepatocytes and to investigate the role of overexpressing miR-146a on rat hepatic fibrosis. The results of the present study showed that miR-146a/SMAD4 is a key signaling cascade that inhibits hepatocyte EMT, and the introduction of miR-146a might present a promising therapeutic option for liver fibrosis. +transcription factor target 30711519 hsa-mir-494 Nerve Degeneration 3p as a potential therapeutic target. +exosome 30711446 hsa-mir-29 Fibrosis, Renal We hypothesized that intramuscular injection of exosome-encapsulated miR-29 would counteract unilateral ureteral obstruction (UUO)-induced muscle wasting and renal fibrosis. +lncRNA target 30711417 hsa-mir-409 Uterine Cervical Diseases 3p may represent a useful early marker and a potential therapeutic target for cervical cancer. +other 30711417 hsa-mir-34c Uterine Cervical Diseases 5p were significantly upregulated in dysplastic cervical tissues. +other 30711417 hsa-mir-132 Uterine Cervical Diseases 5p were significantly upregulated in dysplastic cervical tissues. +other 30711417 hsa-mir-10b Uterine Cervical Diseases 5p were significantly upregulated in dysplastic cervical tissues. +other 30711417 hsa-mir-10a Uterine Cervical Diseases 5p were significantly upregulated in dysplastic cervical tissues. +other 30711417 hsa-mir-141 Uterine Cervical Diseases 5p were significantly upregulated in dysplastic cervical tissues. +other 30711417 hsa-mir-411 Uterine Cervical Diseases 5p were significantly upregulated in dysplastic cervical tissues. +circulation_biomarker_diagnosis_up 30711160 hsa-mir-29a Tuberculosis The performance of miR-29a-3p present in the blood in discriminating active TB from latent TB and healthy controls indicates it may be a useful biomarker for diagnosis of TB. +transcription factor target 30711014 hsa-mir-7 Arthritis, Rheumatoid The aim of this preliminary study was to investigate the expression of ciRS-7 in patients with rheumatoid arthritis (RA) as well as the correlation between ciRS-7 and the target genes of miR-7. +lncRNA target 30710754 hsa-mir-155 Carcinoma, Hepatocellular CONCLUSION: Via modulating the miR-155/Tim-3 pathway, repression of NEAT1 restrained CD8(+)T cell apoptosis and enhanced the cytolysis activity against HCC, implying an effective target for improving the outcome of immunotherapy. +lncRNA target 30710750 hsa-mir-137 Pancreatic Carcinoma RESULTS: The results showed that doxorubicin (Dox) induced autophagy but downregulated the expression level of miR-137 in pancreatic cancer (PC) cells. Therefore, miR-137 may act as a potential therapeutic target for pancreatic cancer. +lncRNA target 30710639 hsa-mir-199a Osteoporosis Taken together, current results indicate that miR-199a-3p regulate adipogenesis of BMMSCs by targeting KDM6A/WNT signaling, which highlights a new insight for a better understanding of molecular mechanism and stem cell based therapy on osteoporotic diseases. +lncRNA target 30710569 hsa-mir-142 Spinal Injuries Sorafenib mimics the treatment effect of SNCI via downregulation of miR +genetics_overexpression_promote 30710498 hsa-mir-543 Uterine Cervical Neoplasms Overexpression of miR-543 in CC cell lines remarkably inhibited cell proliferation, invasion and migration, caused cell cycle arrest, promoted apoptosis in vitro, and suppressed tumor growth in vivo, whereas miR-543 inhibitor showed the opposite effect. +genetics_overexpression_suppress 30710422 hsa-mir-139 Carcinoma, Hepatocellular 5p, miR-940 and miR-193a-5p, was overexpressed in HCC. +genetics_overexpression_suppress 30710422 hsa-mir-193a Carcinoma, Hepatocellular 5p, miR-940 and miR-193a-5p, was overexpressed in HCC. +genetics_overexpression_suppress 30710422 hsa-mir-940 Carcinoma, Hepatocellular 5p, miR-940 and miR-193a-5p, was overexpressed in HCC. +genetics_GWAS 30709904 hsa-mir-144 Pulmonary Fibrosis Of note, a lentiviral luciferase reporter carrying the WT 3' UTR of RXFP1 was significantly repressed in IPF lung fibroblasts, whereas a reporter carrying a mutated miR +other 30709758 hsa-mir-99 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: Our data show that miR-99* and miR-194* can possibly serve as biomarkers for clinical outcome in HNSCC. +other 30709758 hsa-mir-194 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: Our data show that miR-99* and miR-194* can possibly serve as biomarkers for clinical outcome in HNSCC. +other 30709584 hsa-mir-1231 Thyroid Cancer, Papillary Additionally, circ_0025033 could directly sponge miR-1231 and miR-1304 in PTC cells. Collectively, this work uncovers a novel signal of circ_0025033/miR-1231/miR-1304 involved in PTC initiation and progression. +other 30709584 hsa-mir-1304 Thyroid Cancer, Papillary Additionally, circ_0025033 could directly sponge miR-1231 and miR-1304 in PTC cells. Collectively, this work uncovers a novel signal of circ_0025033/miR-1231/miR-1304 involved in PTC initiation and progression. +transcription factor target 30709367 hsa-mir-1287 Triple Negative Breast Neoplasms 5p inhibits triple negative breast cancer growth by interaction with phosphoinositide 3-kinase CB, thereby sensitizing cells for PI3Kinase inhibitors. +other 30708026 hsa-mir-17 Immune System Diseases Taken together, our current works not only reveal an innate immune function and a novel regulation pattern of miR-317, but also provide a new insight into the underlying molecular mechanisms of immunity disorder influencing on Drosophila survival. +circulation_biomarker_diagnosis_up 30707968 hsa-mir-24 Ventricular Premature Complexes Our data identify circulating kisspeptins and miR +circulation_biomarker_diagnosis_up 30707968 hsa-mir-27b Pregnancy, Ectopic Interestingly, circulating levels of miR +circulation_biomarker_diagnosis_up 30707968 hsa-mir-27b Ventricular Premature Complexes Interestingly, circulating levels of miR +circulation_biomarker_diagnosis_up 30707968 hsa-mir-24 Pregnancy, Ectopic Our data identify circulating kisspeptins and miR +other 30707940 hsa-mir-146a Encephalomyelitis, Autoimmune, Experimental This study provides insight into the cellular and molecular bases for the therapeutic effects of miR-146a on OPC differentiation and remyelination, and suggests the potential of enhancing miR-146a as a treatment of demyelinating disorders. +lncRNA target 30707636 hsa-mir-193a Leukemia, Myeloid, Acute In conclusion, this research reveals the important role of lncRNA LINC00152 in the AML leukemogenesis through targeting miR-193a/CDK9 axis. +other 30707419 hsa-mir-1 Brain Ischemia These data proved that there is a positive effects of antagomiR-1 on ischemic neuronal injury and neurological impairment. +other 30707326 hsa-mir-5571 Arthritis, Rheumatoid 3p and miR-135b-5p correlate with increased RA risk and activity. +other 30707326 hsa-mir-135b Arthritis, Rheumatoid 3p and miR-135b-5p correlate with increased RA risk and activity. +transcription factor target 30706990 hsa-mir-125b Alzheimer Disease Our data demonstrated that the cAMP-C/EBPalpha/miR-125b/GluN2A signaling pathway is important to the neuroprotective effects of MT2 activation in Abeta-induced dendritic injuries and learning/memory disorders, providing a novel therapeutic target for the treatment of AD synaptopathy. +circulation_biomarker_diagnosis_up 30706982 hsa-mir-4425 Glioma Regarding the mechanism, HCG11 was abundant in the cytoplasm of glioma cells and interacted with miR-4425 to release the expression of MTA3. +other 30706734 hsa-mir-10a Essential Hypertension And the ROC analysis shows that the combined line with BMI and miR-10a-5p was a values marker for EH (AUC: 0.728, P < 0.0001).Conclusions: Lower expression of miR-10a-5p, as the key role, is significantly related to the risk of EH and maybe as a potential biomolecule for EH. +genetics_GWAS 30706682 hsa-mir-23b Breast Neoplasms So far, no study regarding rs56103835 polymorphism in the precursor of miR-323b has been conducted in the breast cancer. +transcription factor target 30706373 hsa-mir-377 Duane Retraction Syndrome This study aimed to investigate the regulatory effect and the potential mechanism of miR-377 on high glucose and hypoxia-induced angiogenesis and inflammation in human retinal endothelial cells, and found that the miR-377 level was significantly increased after high glucose and hypoxia-mimetic agent to simulate the DR milieu. Our study suggests that miR-377 may be used as a potential novel target for prevention strategy for DR. +other 30706130 hsa-mir-16 Giant Cell Arteritis RESULTS: Consequently, miR-16 was down-regulated in ESCC, GCA and GNCA patients compared with NCs (all P < 0.001), while up-regulated in PDAC patients (P = 0.001), LAC, LSCC and EEC patients (all P < 0.001). The areas under the receiver operating characteristic (ROC) curve of miR-16 in GCA, ESCC, LAC, LSCC, GNCA, PDAC and EEC were 0.881, 0.780, 0.757, 0.693, 0.602, 0.614 and 0.681, respectively. +other 30706130 hsa-mir-16 Esophageal Neoplasms RESULTS: Consequently, miR-16 was down-regulated in ESCC, GCA and GNCA patients compared with NCs (all P < 0.001), while up-regulated in PDAC patients (P = 0.001), LAC, LSCC and EEC patients (all P < 0.001). The areas under the receiver operating characteristic (ROC) curve of miR-16 in GCA, ESCC, LAC, LSCC, GNCA, PDAC and EEC were 0.881, 0.780, 0.757, 0.693, 0.602, 0.614 and 0.681, respectively. +other 30706130 hsa-mir-16 Ectrodactyly-cleft lip-palate syndrome RESULTS: Consequently, miR-16 was down-regulated in ESCC, GCA and GNCA patients compared with NCs (all P < 0.001), while up-regulated in PDAC patients (P = 0.001), LAC, LSCC and EEC patients (all P < 0.001). The areas under the receiver operating characteristic (ROC) curve of miR-16 in GCA, ESCC, LAC, LSCC, GNCA, PDAC and EEC were 0.881, 0.780, 0.757, 0.693, 0.602, 0.614 and 0.681, respectively. +other 30706130 hsa-mir-16 Coronary Artery Disease RESULTS: Consequently, miR-16 was down-regulated in ESCC, GCA and GNCA patients compared with NCs (all P < 0.001), while up-regulated in PDAC patients (P = 0.001), LAC, LSCC and EEC patients (all P < 0.001). The areas under the receiver operating characteristic (ROC) curve of miR-16 in GCA, ESCC, LAC, LSCC, GNCA, PDAC and EEC were 0.881, 0.780, 0.757, 0.693, 0.602, 0.614 and 0.681, respectively. +other 30706130 hsa-mir-16 Carcinoma, Hepatocellular RESULTS: Consequently, miR-16 was down-regulated in ESCC, GCA and GNCA patients compared with NCs (all P < 0.001), while up-regulated in PDAC patients (P = 0.001), LAC, LSCC and EEC patients (all P < 0.001). The areas under the receiver operating characteristic (ROC) curve of miR-16 in GCA, ESCC, LAC, LSCC, GNCA, PDAC and EEC were 0.881, 0.780, 0.757, 0.693, 0.602, 0.614 and 0.681, respectively. +other 30706130 hsa-mir-16 Pancreatic Carcinoma RESULTS: Consequently, miR-16 was down-regulated in ESCC, GCA and GNCA patients compared with NCs (all P < 0.001), while up-regulated in PDAC patients (P = 0.001), LAC, LSCC and EEC patients (all P < 0.001). The areas under the receiver operating characteristic (ROC) curve of miR-16 in GCA, ESCC, LAC, LSCC, GNCA, PDAC and EEC were 0.881, 0.780, 0.757, 0.693, 0.602, 0.614 and 0.681, respectively. +other 30706130 hsa-mir-16 Carcinoma, Small Cell RESULTS: Consequently, miR-16 was down-regulated in ESCC, GCA and GNCA patients compared with NCs (all P < 0.001), while up-regulated in PDAC patients (P = 0.001), LAC, LSCC and EEC patients (all P < 0.001). The areas under the receiver operating characteristic (ROC) curve of miR-16 in GCA, ESCC, LAC, LSCC, GNCA, PDAC and EEC were 0.881, 0.780, 0.757, 0.693, 0.602, 0.614 and 0.681, respectively. +genetics_overexpression_promote 30705594 hsa-mir-143 Stomach Neoplasms The rescue in vitro assays showed that the effects of ZEB2-AS1 overexpression on gastric cancer cell proliferation, growth and invasion was mediated via miR +transcription factor target 30704538 hsa-mir-107 Neurodegenerative Diseases In this study, we investigated the regulation of the miR-107/HMGB1/RAGE pathway in degenerated nucleus pulposus cells (NPCs) after hyperbaric oxygen (HBO) treatment. CONCLUSIONS: HBO inhibits pathways related to HMGB1/RAGE signaling via upregulation of miR-107 expression in degenerated human NPCs. +other 30704473 hsa-mir-497 Cleft Lip Our subnetwork analysis pinpointed two candidate miRNAs, hsa-mir-27b and hsa-mir-497, activating the Wnt pathway that was associated with CL. +other 30704473 hsa-mir-27b Cleft Lip Our subnetwork analysis pinpointed two candidate miRNAs, hsa-mir-27b and hsa-mir-497, activating the Wnt pathway that was associated with CL. +other 30704304 hsa-let-7a Concussion, Sports-Related 3p, and miR-let-7a-5p were significantly upregulated acutely following SRC in male and female collegiate athletes compared to baseline levels, though several athletes demonstrated no change or a decrease in expression. +other 30704304 hsa-mir-153 Concussion, Sports-Related 3p, and miR-let-7a-5p were significantly upregulated acutely following SRC in male and female collegiate athletes compared to baseline levels, though several athletes demonstrated no change or a decrease in expression. +other 30704304 hsa-mir-223 Concussion, Sports-Related 3p, and miR-let-7a-5p were significantly upregulated acutely following SRC in male and female collegiate athletes compared to baseline levels, though several athletes demonstrated no change or a decrease in expression. +transcription factor target 30703341 hsa-mir-182 Prostatic Neoplasms Genes that were negatively correlated with miR-182 were enriched for its predicted targets and for genes previously identified as up-regulated in prostate cancer metastases. +other 30702035 hsa-mir-25 Laryngeal Neoplasms Moreover, RT-PCR confirmed that miR-25, miR-100, miR-125b-5p and let-7g were differentially expressed in different laryngocarcinoma cells and human tumor specimens. +other 30702035 hsa-let-7g Laryngeal Neoplasms Moreover, RT-PCR confirmed that miR-25, miR-100, miR-125b-5p and let-7g were differentially expressed in different laryngocarcinoma cells and human tumor specimens. +other 30702035 hsa-mir-125b Laryngeal Neoplasms Moreover, RT-PCR confirmed that miR-25, miR-100, miR-125b-5p and let-7g were differentially expressed in different laryngocarcinoma cells and human tumor specimens. +other 30702035 hsa-mir-100 Laryngeal Neoplasms Moreover, RT-PCR confirmed that miR-25, miR-100, miR-125b-5p and let-7g were differentially expressed in different laryngocarcinoma cells and human tumor specimens. +other 30701698 hsa-mir-15a Muscular Atrophy CONCLUSIONS: The newly identified lncIRS1 acts as a sponge for miR-15 family to regulate IRS1 expression, resulting in promoting skeletal muscle myogenesis and controlling atrophy. +other 30701693 hsa-mir-498 Carcinoma, Non-Small-Cell Lung TMS pre-treatment significantly upregulated the expression of miR-345 and miR-498 increasing the sensitivity of NSCLC cells to gefitinib and inducing apoptosis. +lncRNA target 30701690 hsa-mir-4732 Breast Neoplasms 5p may serve as a tumour suppressor in the initiation of breast cancer, but as a tumour promoter in breast cancer progression by targeting TSPAN13. +genetics_overexpression_promote 30701576 hsa-mir-145 Melanoma 5p overexpression inactivated the NF-kappaB pathway in melanoma in vitro and in vivo, which was reversed by TLR4 overexpression. +lncRNA target 30701536 hsa-mir-128 Coronary Disease This study was performed to clarify the effect of microRNA-128 (miR-128) on the CMEC injury in coronary heart disease (CHD) by binding to insulin receptor substrate 1 (IRS1). CMECs were treated with homocysteine (Hcy), which underwent stress of CHD, followed by treatment of miR-128 mimics/inhibitors or IRS1 siRNA. +lncRNA target 30701447 hsa-mir-146a Adenocarcinoma, Follicular IRAK1, a known target for miR146a, was upregulated in FTC and the increase was mainly appreciable in Hurtle FTC variant. +lncRNA target 30700725 hsa-mir-34c Acquired Immunodeficiency Syndrome Taken together, these findings show a previously unreported mechanism whereby Meth functions as a novel T-cell activator via the sigma-1 signaling pathway, enhancing replication of HIV-1 with expression of miR-34c-5p, and transcriptional activation of NFkappaB, CREB and NFAT1. +other 30700696 hsa-mir-34a Adenocarcinoma of Lung However, miR-34a and miR-34c have different sets of negatively correlated genes in lung adenocarcinoma data from The Cancer Genome Atlas. Similarly, lung adenocarcinoma patients with higher miR-34a/b/c levels had better survival rates than did those with lower levels. +other 30700696 hsa-mir-34 Adenocarcinoma of Lung However, miR-34a and miR-34c have different sets of negatively correlated genes in lung adenocarcinoma data from The Cancer Genome Atlas. Similarly, lung adenocarcinoma patients with higher miR-34a/b/c levels had better survival rates than did those with lower levels. +other 30700445 hsa-mir-26b Urinary Bladder Neoplasms CONCLUSIONS: Our results suggest that miR-26b-5p levels may be prognostic for non-muscle-invasive bladder cancer recurrence, and can feasibly be assessed in baseline tumor tissue from a wide variety of clinical settings. +other 30700264 hsa-mir-195 Cervical Intraepithelial Neoplasia The relative expression of miRNA-195 and miRNA-29a in the missed high-grade lesion group was significantly lower than that in the consistent LSIL/CIN1 group. +other 30700264 hsa-mir-29a Cervical Intraepithelial Neoplasia The relative expression of miRNA-195 and miRNA-29a in the missed high-grade lesion group was significantly lower than that in the consistent LSIL/CIN1 group. +other 30700251 hsa-mir-181a-2 Leukemia, Promyelocytic, Acute A multivariate Cox model suggested that three miRNAs were potential biomarkers of non-M3 AML prognosis, including miR-181a-2, miR-25 and miR-362. +other 30700251 hsa-mir-25 Leukemia, Promyelocytic, Acute A multivariate Cox model suggested that three miRNAs were potential biomarkers of non-M3 AML prognosis, including miR-181a-2, miR-25 and miR-362. +exosome 30700172 hsa-mir-346 Pre-Eclampsia 5p, and miR-618) were found to display statistically significant differential expression between women who developed preeclampsia as compared with those who did not. +exosome 30700172 hsa-mir-376c Pre-Eclampsia 5p, and miR-618) were found to display statistically significant differential expression between women who developed preeclampsia as compared with those who did not. +exosome 30700172 hsa-mir-134 Pre-Eclampsia 5p, and miR-618) were found to display statistically significant differential expression between women who developed preeclampsia as compared with those who did not. +exosome 30700172 hsa-mir-618 Pre-Eclampsia 5p, and miR-618) were found to display statistically significant differential expression between women who developed preeclampsia as compared with those who did not. +exosome 30700172 hsa-mir-196b Pre-Eclampsia 5p, and miR-618) were found to display statistically significant differential expression between women who developed preeclampsia as compared with those who did not. +exosome 30700172 hsa-mir-486 Pre-Eclampsia 5p, and miR-618) were found to display statistically significant differential expression between women who developed preeclampsia as compared with those who did not. +exosome 30700172 hsa-mir-590 Pre-Eclampsia 5p, and miR-618) were found to display statistically significant differential expression between women who developed preeclampsia as compared with those who did not. +lncRNA target 30700111 hsa-mir-21 Stomach Neoplasms Collectively, our results uncover that miR-21 targets PTEN/Akt signaling pathway and regulates cell proliferation, migration and apoptosis in human gastric cancer cells. +circulation_biomarker_diagnosis_ns 30699200 hsa-mir-188 Muscular Dystrophies By miRNA microarray analysis, we identified miR-188 as a novel miRNA that is elevated in the serum of the muscular dystrophy dog model, CXMDJ. +lncRNA target 30698996 hsa-mir-214 Colonic Neoplasms miR-22 and miR-214 targeting BCL9L inhibit proliferation, metastasis, and epithelial-mesenchymal transition by down-regulating Wnt signliang in colon cancer. +lncRNA target 30698996 hsa-mir-22 Colonic Neoplasms miR-22 and miR-214 targeting BCL9L inhibit proliferation, metastasis, and epithelial-mesenchymal transition by down-regulating Wnt signliang in colon cancer. +lncRNA target 30698830 hsa-mir-145 Carcinoma, Hepatocellular In conclusion, our study revealed a novel mechanism explaining TGF-beta1-induced MDR in HCC through upregulating P-gp and BCRP via the SMAD4/HOTAIR/miR-145 axis. +other 30698824 hsa-mir-21 Nasopharyngeal Carcinoma Logistic regression analyses suggested that combination of two NW assays that test for EBNA-1 and hsa-miR-21 had the best performance in detecting NPC. +genetics_GWAS 30698680 hsa-mir-21 Multiple Sclerosis These data collectively define a direct link between fumaric acid ester treatment and hypermethylation of the MIR-21 locus in both CD4 and CD8 T cells and suggest that the immunomodulatory effect of fumaric acid esters in multiple sclerosis is at least in part due to the epigenetic regulation of the brain-homing CCR6+ CD4 and CD8 T cells. +other 30698464 hsa-mir-3 Langer mesomelic dysplasia Transfecting miR-33 mimics into the LMH cells led to a decrease in the mRNA expression of CROT and HADHB (P < 0.01), and this transfection had a similar effect on the proteins (P < 0.05). +lncRNA target 30697802 hsa-mir-503 Uterine Cervical Neoplasms Furthermore, increasing miR-503 expression in CC cells dramatically inhibited cell proliferation, colony formation ability of CC. +other 30697739 hsa-mir-545 Rhabdomyosarcoma We showed that miR-545 was upregulated in the EV71-infected human embryonic kidney (HEK) 293 cells and rhabdomyosarcoma (RD) cells. +transcription factor target 30697640 hsa-mir-23b Lipidoses HepG2 cells were incubated by glucose to induce lipid accumulation and were subsequently transfected with mir-23b mimic and inhibitor. miR-23b reduces the expression and activity of SIRT1 and therefore may be a causative factor in the enhancement of lipid accumulation in HepG2 cells. +other 30697269 hsa-mir-210 Pre-Eclampsia INTRODUCTION: This study aimed to explore the bio-function of miR-210 in the pathogenesis of pre-eclampsia and provide new insights into the diagnosis and treatment of pre-eclampsia. +lncRNA target 30697079 hsa-mir-10a Hepatitis B The upregulation of LINC00346 and CDK1 but the downregulation of miR-10a-5p in HCC was validated in other microarray datasets and TCGA database. CONCLUSION: The LINC00346-miR-10a-5p-CDK1 axis may be an important mechanism for HBV-related HCC, and genes in this ceRNA axis may be potential prognostic biomarkers and therapeutic targets. +lncRNA target 30697057 hsa-mir-4262 Stomach Neoplasms CONCLUSION: Our findings indicate that lower level of miR-4262 predicts poorer prognosis in gastric patients, and miR-4262 can target proto-oncogene CD163 to suppress gastric cancer cell proliferation and invasion. +lncRNA target 30696455 hsa-mir-208a Diabetes Mellitus CONCLUSION: Our results provide the first evidence that early modulation of miR-208a in the diabetic heart induces alterations in the downstream signaling pathway leading to cardiac remodelling and that therapeutic inhibition of miR-208a may be beneficial in preventing diabetes-induced adverse remodelling of the heart. +circulation_biomarker_diagnosis_ns 30696076 hsa-mir-657 Drug Hypersensitivity Though Spatholobus suberectus Dunn (SSD) has been reported to have anti-virus, anti-osteoclastogenesis, and anti-inflammation activities, its underlying anti-cancer mechanism has never been elucidated in association with the role of miR-657 in endoplasmic reticulum (ER) stress-related apoptosis to date. Overall, these findings provide scientific evidence that miR657 is an onco-miRNA targeting the ER stress signal pathway and SSD induces apoptosis via the inhibition of miR-657, ROS, and the activation of p-ATF2 and CHOP as a potent anti-cancer agent for myeloid-originated hematological cancer. +transcription factor target 30696076 hsa-mir-657 Myeloproliferative Disorders Overall, these findings provide scientific evidence that miR657 is an onco-miRNA targeting the ER stress signal pathway and SSD induces apoptosis via the inhibition of miR-657, ROS, and the activation of p-ATF2 and CHOP as a potent anti-cancer agent for myeloid-originated hematological cancer. +circulation_biomarker_diagnosis_ns 30696076 hsa-mir-657 Sexually Transmitted Diseases Though Spatholobus suberectus Dunn (SSD) has been reported to have anti-virus, anti-osteoclastogenesis, and anti-inflammation activities, its underlying anti-cancer mechanism has never been elucidated in association with the role of miR-657 in endoplasmic reticulum (ER) stress-related apoptosis to date. +lncRNA target 30696075 hsa-mir-10a Pulmonary Disease, Chronic Obstructive The upregulation of hsa-miR-10a-5p and hsa-miR-146a-5p in both AHBE and CHBE was confirmed with quantitative polymerase chain reaction (qPCR). Using bioinformatic methods, we further identified putative targets of these microRNAs, which were downregulated in both AHBE and CHBE: miR-10a-5p might suppress BCL2, FGFR3, FOXO3, PDE4A, PDE4C, and PDE7A; miR-146a-5p might suppress BCL2, INSR, PDE4D, PDE7A, PDE7B, and PDE11A. +lncRNA target 30696075 hsa-mir-10a Asthma The upregulation of hsa-miR-10a-5p and hsa-miR-146a-5p in both AHBE and CHBE was confirmed with quantitative polymerase chain reaction (qPCR). Using bioinformatic methods, we further identified putative targets of these microRNAs, which were downregulated in both AHBE and CHBE: miR-10a-5p might suppress BCL2, FGFR3, FOXO3, PDE4A, PDE4C, and PDE7A; miR-146a-5p might suppress BCL2, INSR, PDE4D, PDE7A, PDE7B, and PDE11A. +circulation_biomarker_diagnosis_ns 30696075 hsa-mir-146a Pulmonary Disease, Chronic Obstructive Increased serum miR-146a-5p level was also noted in patients with asthma and COPD as compared with normal control subjects. In summary, our study revealed possible mechanisms mediated by miR-10a-5p and miR-146a-5p in the pathogenesis of both asthma and COPD. +circulation_biomarker_diagnosis_ns 30696075 hsa-mir-146a Asthma Increased serum miR-146a-5p level was also noted in patients with asthma and COPD as compared with normal control subjects. In summary, our study revealed possible mechanisms mediated by miR-10a-5p and miR-146a-5p in the pathogenesis of both asthma and COPD. +other 30696040 hsa-mir-34a Uterine Cervical Neoplasms 5p and 3p Strands of miR-34 Family Members Have Differential Effects in Cell Proliferation, Migration, and Invasion in Cervical Cancer Cells. This study provides insights into the roles of passenger strands (strand*) of the miR-34 family in cervical cancer. +genetics_overexpression_suppress 30695725 hsa-mir-141 Carcinoma, Hepatocellular Thus, overexpression of miR +genetics_overexpression_promote 30695677 hsa-mir-212 Pulmonary Disease, Chronic Obstructive 5p inhibited the overexpression of these genes. +lncRNA target 30694767 hsa-mir-145 Breast Neoplasms 5p played a suppressive role in the proliferation of breast cancer cells by targeting SOX2, and miR +lncRNA target 30693688 hsa-mir-101a Alzheimer Disease CONCLUSIONS: Osthole inhibits the expression of APP by up-regulating miR-101a-3p in AD cell model. +lncRNA target 30693518 hsa-mir-133a Pancreatic Carcinoma As predicted by an online tool, FEZF1-AS1 could target miR-133a to inhibit its expression; under the normoxic condition, FEZF1-AS1 exerted its effect on PC cell lines through miR-133a/EGFR axis. +transcription factor target 30693011 hsa-mir-96 Blast Crisis Collectively, our results indicate that miR396 negatively regulates rice blast disease- resistance via suppressing multiple OsGRFs, which in turn differentially control growth and yield. +other 30692590 hsa-mir-124 Inflammation The specific dual ability of ABX464 to generate both anti-inflammatory miR-124 and spliced viral RNA may have applicability for the treatment of both inflammatory diseases and HIV infection. +other 30692590 hsa-mir-124 Acquired Immunodeficiency Syndrome Here, using RNA CaptureSeq and deep sequencing, we report that ABX464 enhances the splicing of HIV RNA in infected PBMCs from six healthy individuals and also the expression and splicing of a single long noncoding RNA to generate the anti-inflammatory miR-124 both ex vivo and in HIV patients. The specific dual ability of ABX464 to generate both anti-inflammatory miR-124 and spliced viral RNA may have applicability for the treatment of both inflammatory diseases and HIV infection. +lncRNA target 30692511 hsa-mir-98 Adenocarcinoma of Lung Together, our study elucidates oncogenic roles of linc00665-miR98-AKR1B10 axis in LUAD tumorigenesis, which may serve as potential diagnostic biomarkers and therapeutic targets. +lncRNA target 30692507 hsa-let-7 Muscular Dystrophy, Duchenne sPIF promotes myoblast differentiation and utrophin expression while inhibiting fibrosis in Duchenne muscular dystrophy via the H19/miR-675/let-7 and miR-21 pathways. In conclusion, sPIF promoted the differentiation of DMD myoblasts, increased utrophin expression via the H19/miRNA-675/let-7 pathway, and reduced muscle fibrosis possibly via the upregulation of miR-675 and inhibition of miR-21 expression. +lncRNA target 30692507 hsa-mir-21 Muscular Dystrophy, Duchenne sPIF promotes myoblast differentiation and utrophin expression while inhibiting fibrosis in Duchenne muscular dystrophy via the H19/miR-675/let-7 and miR-21 pathways. In conclusion, sPIF promoted the differentiation of DMD myoblasts, increased utrophin expression via the H19/miRNA-675/let-7 pathway, and reduced muscle fibrosis possibly via the upregulation of miR-675 and inhibition of miR-21 expression. +lncRNA target 30692507 hsa-mir-675 Muscular Dystrophy, Duchenne sPIF promotes myoblast differentiation and utrophin expression while inhibiting fibrosis in Duchenne muscular dystrophy via the H19/miR-675/let-7 and miR-21 pathways. In conclusion, sPIF promoted the differentiation of DMD myoblasts, increased utrophin expression via the H19/miRNA-675/let-7 pathway, and reduced muscle fibrosis possibly via the upregulation of miR-675 and inhibition of miR-21 expression. +genetics_overexpression_promote 30692230 hsa-mir-101 Osteosarcoma In addition, overexpression of ZEB2 could rescue the inhibition effect of proliferation and invasion induced by miR-101 in osteosarcoma cells. +epigenetics 30692098 hsa-mir-155 Myeloproliferative Disorders The increased prevalence of BRCA1 promoter methylation, resulting in repressed BRCA1, may have an additional role in leukemogenesis by increasing miR-155 expression, which then inhibits transcription factors associated with normal myeloid differentiation. +circRNA target 30692016 hsa-mir-127 Osteoarthritis Mechanistic study showed that circRNA.33186 directly binds to and inhibits miR5p, thereby increasing MMP-13 expression, and contributes to OA pathogenesis. +lncRNA target 30691859 hsa-mir-495 Sarcoma, Ewing The proliferation of the EC cells that were transfected with miR-495 mimics was markedly inhibited, and apoptosis was significantly promoted. +lncRNA target 30691465 hsa-mir-425 Glioma TAL1 was a direct target of miR-346/miR +transcription factor target 30690026 hsa-mir-19b Hypertension Taken together, these findings indicate that pathological cyclic stretch induces vascular remodeling by promoting VSMC proliferation via miR-19b-3p/CTGF pathway, and point to CTGF as a potential therapeutic target for hypertension. +other 30689558 hsa-mir-183 Carcinoma, Renal Cell 5p expression is an independent factor for predicting RCC's worse prognosis. +circulation_biomarker_prognosis_ns 30689553 hsa-mir-214 Stomach Neoplasms RESULTS: In this study, we found that plasma LINC00086 expression was significantly lower, whereas plasma miR-214 expression was significantly higher in GC patients than in normal individuals. +transcription factor target 30689165 hsa-mir-93 Uterine Cervical Neoplasms 5p may have blocked HPV-positive cervical cancer development by targeting of BTG3. +transcription factor target 30689165 hsa-mir-93 Papillomavirus Infections 5p may have blocked HPV-positive cervical cancer development by targeting of BTG3. +other 30688676 hsa-mir-221 Pterygium 3p is decreased in primary pterygium tissue, and these miRNAs may play a role in the pathogenesis of pterygium. +other 30688676 hsa-mir-184 Pterygium 3p is decreased in primary pterygium tissue, and these miRNAs may play a role in the pathogenesis of pterygium. +other 30688676 hsa-mir-182 Pterygium 3p is decreased in primary pterygium tissue, and these miRNAs may play a role in the pathogenesis of pterygium. +other 30688676 hsa-mir-126 Pterygium 5p in primary pterygium tissue and compare these levels with those in healthy conjunctiva tissue. +other 30688676 hsa-mir-205 Pterygium 5p in primary pterygium tissue and compare these levels with those in healthy conjunctiva tissue. +other 30688676 hsa-mir-183 Pterygium 3p is decreased in primary pterygium tissue, and these miRNAs may play a role in the pathogenesis of pterygium. +other 30688097 hsa-mir-515 Stomach Neoplasms In conclusion, circ_0067997 was identified to be an oncogene in GC by regulating miR5p/XIAP axis. +epigenetics 30688091 hsa-mir-145 Atherosclerosis In addition, we found atherosclerosis-linked differentially methylated regions associated with ANGPT2 and with sequences encoding miR-145, a microRNA that targets ANGPT2 mRNA in cancers. +transcription factor target 30687333 hsa-mir-19b Acquired Immunodeficiency Syndrome These results highlight the importance of miR-19b to control viral levels, which facilitate an understanding of human immunodeficiency virus pathogenesis and provide potential targets for improved immune intervention. +circulation_biomarker_diagnosis_ns 30687316 hsa-mir-101 Sepsis 3p) expressed in plasma were significantly higher in AOSD patients than in sepsis patients (P < 0.05). +circulation_biomarker_diagnosis_up 30687316 hsa-mir-29c Still's Disease, Adult-Onset 3p) expressed in plasma were significantly higher in AOSD patients than in sepsis patients (P < 0.05). +circulation_biomarker_diagnosis_ns 30687316 hsa-mir-101 Still's Disease, Adult-Onset 3p) expressed in plasma were significantly higher in AOSD patients than in sepsis patients (P < 0.05). +circulation_biomarker_diagnosis_ns 30687316 hsa-mir-142 Still's Disease, Adult-Onset 3p) expressed in plasma were significantly higher in AOSD patients than in sepsis patients (P < 0.05). +circulation_biomarker_diagnosis_up 30687316 hsa-mir-29c Sepsis 3p) expressed in plasma were significantly higher in AOSD patients than in sepsis patients (P < 0.05). +circulation_biomarker_diagnosis_up 30687316 hsa-mir-141 Still's Disease, Adult-Onset 3p) expressed in plasma were significantly higher in AOSD patients than in sepsis patients (P < 0.05). +circulation_biomarker_diagnosis_up 30687316 hsa-mir-141 Sepsis 3p) expressed in plasma were significantly higher in AOSD patients than in sepsis patients (P < 0.05). +circulation_biomarker_diagnosis_ns 30687316 hsa-mir-142 Sepsis 3p) expressed in plasma were significantly higher in AOSD patients than in sepsis patients (P < 0.05). +lncRNA target 30687129 hsa-mir-1 Muscular Atrophy We predicted miRs targeting deregulated gene expression following bed rest as a model of microgravity exposure; namely, let-7a-5p, miR-125b-5p for over-expressed genes in SOL and VL; miR +lncRNA target 30687129 hsa-let-7a Muscular Atrophy Moreover, promotion of an M2-like macrophage phenotype (IL-13, IL-10) by let-7a down-regulation and simultaneous promotion of an M1-like macrophage (IL-6, TNF-alpha) phenotype through the over-expression of EEF2 lead to a deregulation between M1/M2 tuning, that is responsible for a first pro-inflammatory/proliferative phase followed by an anti-inflammatory pro-myogenic phase during skeletal muscle regeneration after injury. +lncRNA target 30687129 hsa-mir-125b Muscular Atrophy We predicted miRs targeting deregulated gene expression following bed rest as a model of microgravity exposure; namely, let-7a-5p, miR-125b-5p for over-expressed genes in SOL and VL; miR +genetics_overexpression_promote 30687106 hsa-mir-181a Stomach Neoplasms Moreover, miRNA-181a is overexpressed in GC cells, and downregulation of miRNA-181a induced cell apoptosis and suppressed the proliferation, invasion, and metastasis of GC cells both in vitro and in vivo. +transcription factor target 30687089 hsa-mir-26 Carcinoma, Non-Small-Cell Lung Our results indicated that miR-26 induced apoptosis and inhibited autophagy in human NSCLC cells through the TGF-beta1-JNK signaling pathway, suggesting that miR-26 could be a potential novel target for the treatment of NSCLC. +lncRNA target 30685990 hsa-mir-1 Stomach Neoplasms Therefore, miR-31 can be considered as a potential target molecule in the targeted therapy of gastric cancer (Fig. +genetics_overexpression_suppress 30685769 hsa-mir-4301 Nasopharyngeal Neoplasms miR-4301 overexpression dramatically inhibited NPC cell proliferation, migration, and invasion. +lncRNA target 30685432 hsa-mir-203 Colorectal Neoplasms miR-203 expression was impaired while sevoflurane reversed the expression of miR-203 in CRC cells. These results indicated that sevoflurane suppressed cell migration and invasion through regulating ERK/MMP-9 pathway via miR-203/Robo1 in CRC cells, indicating important clinical implications for anesthetic agents to prevent metastasis in CRC. +lncRNA target 30685413 hsa-mir-193a Carcinoma, Non-Small-Cell Lung Our findings support a model of miR-193a-3p as a suppressor of metastatic disease progression in NSCLC via modulation of the p53/Slug/L1CAM pathway. +lncRNA target 30685303 hsa-mir-515 Prostatic Neoplasms 5p acted as a tumor suppressor to regulate cell proliferation, migration and invasion via targeting TRIP13 in prostate cancer. +transcription factor target 30684894 hsa-mir-20a Allergic Inflammation hsa-miR-20a-5p attenuates allergic inflammation in HMC-1 cells by targeting HDAC4. +genetics_knock down_suppress 30684759 hsa-mir-215 Cardiomyopathies 5p in myocardial injury, overexpression/knockdown of miR +genetics_knock down_suppress 30684680 hsa-mir-24 Scholte syndrome Knockdown of miR-24 in SCHL cells resulted in increased Insig1 protein, and subsequently reduced mature Srebp1 protein and expression of genes required for LC-PUFA biosynthesis, and these effects could be attenuated after additional insig1 knockdown. +other 30684575 hsa-mir-15a Glioma Experimental results suggested that miR-15a/b-5p and HDGF involved in AGAP2-AS1-mediated glioma cell proliferation. In summary, this study demonstrated that AGAP2-AS1 promoted glioma cell proliferation by sponging miR-15a/b-5p to upregulate the expression of HDGF. +other 30684575 hsa-mir-15b Glioma Experimental results suggested that miR-15a/b-5p and HDGF involved in AGAP2-AS1-mediated glioma cell proliferation. In summary, this study demonstrated that AGAP2-AS1 promoted glioma cell proliferation by sponging miR-15a/b-5p to upregulate the expression of HDGF. +circulation_biomarker_diagnosis_up 30684524 hsa-mir-34a Thyroid Cancer, Papillary After multiphase experiment processes, miR-346, miR-10a-5p and miR-34a-5p were found significantly elevated in PTC plasma samples relative to HCs. MiR-346 and miR-34a-5p but not miR-10a-5p were up-regulated in PTC tissues. +circulation_biomarker_diagnosis_up 30684524 hsa-mir-346 Thyroid Cancer, Papillary After multiphase experiment processes, miR-346, miR-10a-5p and miR-34a-5p were found significantly elevated in PTC plasma samples relative to HCs. MiR-346 and miR-34a-5p but not miR-10a-5p were up-regulated in PTC tissues. +circulation_biomarker_diagnosis_up 30684524 hsa-mir-10a Thyroid Cancer, Papillary After multiphase experiment processes, miR-346, miR-10a-5p and miR-34a-5p were found significantly elevated in PTC plasma samples relative to HCs. MiR-346 and miR-34a-5p but not miR-10a-5p were up-regulated in PTC tissues. +exosome 30684318 hsa-mir-26a Ischemic Stroke CONCLUSIONS: Interleukinpolarized microglia cells might ameliorate the damage caused by ischemic stroke by promoting angiogenesis through the secretion of exosomes containing miRNA-26a. +exosome 30684318 hsa-mir-26a Ischemia CONCLUSIONS: Interleukinpolarized microglia cells might ameliorate the damage caused by ischemic stroke by promoting angiogenesis through the secretion of exosomes containing miRNA-26a. +other 30684296 hsa-mir-34 Carcinoma, Squamous Cell In contrast, the oSCC tumours showed downregulation of this cluster as well as downregulation of the miR-34 family, which may favour oSCC tumour cell metabolism. +transcription factor target 30684296 hsa-mir-200 Carcinoma, Squamous Cell Whereas, ES lesions in general were associated with downregulation of the miR-200 family, which may trigger epithelial-mesenchymal transition, ESM lesions were associated with upregulation of the proposed tumour-suppressive miRNA cluster on equine chromosome 24. +genetics_overexpression_promote 30684287 hsa-mir-128b Stomach Neoplasms In addition, SNAI1 overexpression or miR-128b inhibition partly reversed the effects of PGC-1 inhibition in GC cells. +genetics_overexpression_promote 30684280 hsa-mir-27b Acute Kidney Injury CONCLUSION: Overexpression of LINC00520 contributes to the aggravation of AKI by targeting miR-27b-3p/ OSMR. +other 30683847 hsa-mir-17 Stomach Neoplasms 5p to regulate EGR2 expression. +genetics_overexpression_promote 30683806 hsa-mir-10a Cardiomyopathies Moreover, miR-10a overexpression could promote miR-10a, collagen-I, collagen III, alpha-SMA, and TGF-beta1 protein expression and increase the levels of hydroxyproline but reduced Smad7 protein expression in atrial tissues and CFs in AF rats. +genetics_overexpression_promote 30683806 hsa-mir-10a Atrial Fibrillation Moreover, miR-10a overexpression could promote miR-10a, collagen-I, collagen III, alpha-SMA, and TGF-beta1 protein expression and increase the levels of hydroxyproline but reduced Smad7 protein expression in atrial tissues and CFs in AF rats. +genetics_overexpression_promote 30683474 hsa-mir-708 Carcinoma, Pancreatic Ductal 5p overexpression enhanced the ability of proliferation, invasion and migration in PDAC cell lines. +other 30683137 hsa-mir-221 Inflammation CONCLUSION: Our findings provide some insight that prior interrupted isoflurane administration could regulate miR-221, and downstream effectors (mRNAs) and resulted in actual attenuation of inflammation and spasm of LIMA in patients undergoing OPCABG surgery. +other 30683137 hsa-mir-221 Spasm CONCLUSION: Our findings provide some insight that prior interrupted isoflurane administration could regulate miR-221, and downstream effectors (mRNAs) and resulted in actual attenuation of inflammation and spasm of LIMA in patients undergoing OPCABG surgery. +lncRNA target 30683134 hsa-mir-29a Glioblastoma In PTEN-deficient glioblastoma cells, however, miR-29a nevertheless activates AKT by downregulating the metastasis suppressor, EphB3. +circulation_biomarker_prognosis_ns 30683101 hsa-mir-126 Osteosarcoma, Juxtacortical In the present study, we assessed the potential of circulating microRNA-214 (miR-214) and - 126 (miR-126) to predict time to metastasis and death in dogs with OSA treated with amputation and chemotherapy. CONCLUSIONS: Circulating miR-214, - 126, and an integrated prognostic score have strong potential to predict the outcome of canine appendicular OSA patients receiving amputation and chemotherapy. +circulation_biomarker_prognosis_ns 30683101 hsa-mir-214 Osteosarcoma, Juxtacortical In the present study, we assessed the potential of circulating microRNA-214 (miR-214) and - 126 (miR-126) to predict time to metastasis and death in dogs with OSA treated with amputation and chemotherapy. CONCLUSIONS: Circulating miR-214, - 126, and an integrated prognostic score have strong potential to predict the outcome of canine appendicular OSA patients receiving amputation and chemotherapy. +other 30682439 hsa-mir-3473 Acute Kidney Injury In the differential analysis, miR-3473 was specifically up-regulated in the glomerular injury models. +genetics_overexpression_suppress 30682335 hsa-mir-21 Reperfusion Injury 5p targeting PTEN and PDCD4, while artificial overexpressing PTEN or PDCD4 significantly attenuated the anti-apoptotic effect of MSC-Exo in vitro. +other 30682089 hsa-mir-186 Acquired Immunodeficiency Syndrome Here, we broaden the understanding of the HIV-1 infection process, and show that miRNA-186, 210 and 222 are up-regulated following HIV-1 infection of human Sup-T1 cells. To conclude, we found that human miR-186, 210 and 222 directly regulate the human genes Dicer1, HRB and HIV-EP2, thus may be filling key roles during HIV-1 replication and miRNA biogenesis. +genetics_overexpression_promote 30681889 hsa-mir-21 Colorectal Neoplasms For this, CRC SW480 and HCT116 cells were infected with lentiviruses of SAV1 overexpression vector (lenti-SAV1) and SAV1 short hairpin RNA (sh-SAV1) to overexpress and silence SAV1 respectively, or transfected with microRNA-21 (miR-21) mimic to overexpress miR-21. +other 30681251 hsa-mir-342 Diabetes Mellitus CONCLUSION: The results of this study suggest that the expression of miRNAs 342 and 450 and NOX-4 activity may help identify those individuals with T2D at high risk for developing CAD as well as the prognosis in those with established CAD. +other 30681251 hsa-mir-342 Coronary Artery Disease CONCLUSION: The results of this study suggest that the expression of miRNAs 342 and 450 and NOX-4 activity may help identify those individuals with T2D at high risk for developing CAD as well as the prognosis in those with established CAD. +genetics_knock down_suppress 30680929 hsa-mir-200c Cardiomegaly Furthermore, inhibiting MLCK impaired the anti-hypertrophic effects contributions produced by the knockdown of miR-200c. CONCLUSION: Our studies suggest that miR-200c may serve as a potential therapeutic target that could delay hypertrophy. +other 30680612 hsa-mir-106b Stomach Neoplasms OBJECTIVE(S): We aimed to evaluate the effects of DHA and docetaxel on the expression level of metastasis-related genes, including MMP-2 and talin-2, and their controlling miRNAs, miR-106b and miR-194, in metastatic GC cell line, MKN45. +other 30680612 hsa-mir-194 Stomach Neoplasms OBJECTIVE(S): We aimed to evaluate the effects of DHA and docetaxel on the expression level of metastasis-related genes, including MMP-2 and talin-2, and their controlling miRNAs, miR-106b and miR-194, in metastatic GC cell line, MKN45. +other 30680535 hsa-mir-199a Carcinoma, Hepatocellular KNG1, CDK1, EHHADH, CYP3A4, hsa-miR-199a-5p and hsa-miR3p might be biomarkers in the occurrence of HCC. +other 30680535 hsa-mir-455 Carcinoma, Hepatocellular KNG1, CDK1, EHHADH, CYP3A4, hsa-miR-199a-5p and hsa-miR3p might be biomarkers in the occurrence of HCC. +genetics_overexpression_promote 30680031 hsa-mir-101 Urinary Bladder Neoplasms Both miR-101 overexpression and FZD4 inhibition caused a significant reduction of the migration and invasion of bladder cancer cells, whereas overexpression of FZD4 reversed the suppressive effects of miR-101 on bladder cancer cell migration and invasion. +genetics_knock down_suppress 30680011 hsa-mir-200a Glioma The present study reveals the overexpression of PVT1 in glioma tissue and cells and the oncogenic role of PVT1 in gliomagenesis via sponging miR-200a, thus providing a potential biomarker for the early detection of glioma and prognosis prediction. +lncRNA target 30680010 hsa-mir-490 Stomach Neoplasms 3p regulated proliferation and apoptosis in gastric cancer cells via direct targeting of AKT1. +lncRNA target 30680008 hsa-mir-21 Hypoxia miR-21 directly targets the 3'-UTR of Akap8 and Bard1 mRNA and enhances the inhibitory effects of loperamide on Akap8 and Bard1 expression in rat cardiomyocytes after hypoxia/reoxygenation. +genetics_overexpression_promote 30679992 hsa-mir-373 Urinary Bladder Neoplasms It was concluded that miRNA-373 overexpression may promote urinary bladder cancer cell proliferation, migration and invasion by upregulating EGFR. +lncRNA target 30679990 hsa-mir-146b Myocardial Infarction A PI3K inhibitor decreased the effect of microRNA-146b on vascular inflammation and apoptosis following myocardial infarction. +circulation_biomarker_diagnosis_up 30679988 hsa-mir-361 Retinoblastoma 3p was significantly downregulated in RB tissues, RB serum and RB cell lines compared with normal retinal tissues and normal serum. +transcription factor target 30679767 hsa-mir-27b Interstitial Fibrosis, Renal In conclusion, the activation of C3a/p38/XBP-1s pathway induces the expression of LOC105375913 in tubular cells, and LOC105375913 increases the level of snail and induces tubulointerstitial fibrosis through competitive binding of miR-27b in tubular cells of FSGS patients. +other 30679653 hsa-mir-132 Stress Disorders, Traumatic We here firstly provide evidence for a regulation of amygdala miRNA expression in learned safety and propose miR-132 as signature molecule to be considered in future preclinical and translational approaches testing the transdiagnostic relevance of learned safety as intermediate phenotype in fear and stress-related disorders. +circulation_biomarker_diagnosis_down 30679580 hsa-mir-15b Cardiotoxicity MI down-regulated plasma levels of miRNA 15b-5p and 194-5p in obese and non-obese animals, which were associated with cardiac function, mitochondrial lipids and myocardial fibrosis, with miRNA 15b-5p levels being independently associated with cardiac fibrosis. +circulation_biomarker_diagnosis_down 30679580 hsa-mir-15b Obesity MI down-regulated plasma levels of miRNA 15b-5p and 194-5p in obese and non-obese animals, which were associated with cardiac function, mitochondrial lipids and myocardial fibrosis, with miRNA 15b-5p levels being independently associated with cardiac fibrosis. +circulation_biomarker_diagnosis_down 30679580 hsa-mir-15b Myocardial Infarction MI down-regulated plasma levels of miRNA 15b-5p and 194-5p in obese and non-obese animals, which were associated with cardiac function, mitochondrial lipids and myocardial fibrosis, with miRNA 15b-5p levels being independently associated with cardiac fibrosis. +circulation_biomarker_diagnosis_down 30679580 hsa-mir-194 Obesity MI down-regulated plasma levels of miRNA 15b-5p and 194-5p in obese and non-obese animals, which were associated with cardiac function, mitochondrial lipids and myocardial fibrosis, with miRNA 15b-5p levels being independently associated with cardiac fibrosis. +circulation_biomarker_diagnosis_down 30679580 hsa-mir-194 Cardiotoxicity MI down-regulated plasma levels of miRNA 15b-5p and 194-5p in obese and non-obese animals, which were associated with cardiac function, mitochondrial lipids and myocardial fibrosis, with miRNA 15b-5p levels being independently associated with cardiac fibrosis. +circulation_biomarker_diagnosis_down 30679580 hsa-mir-194 Myocardial Infarction MI down-regulated plasma levels of miRNA 15b-5p and 194-5p in obese and non-obese animals, which were associated with cardiac function, mitochondrial lipids and myocardial fibrosis, with miRNA 15b-5p levels being independently associated with cardiac fibrosis. +lncRNA target 30679387 hsa-mir-708 Breast Neoplasms Here, we show that multilayered nanoparticles (NPs) carrying the metastasis suppressor microRNA miR-708 (miR708-NP) localize to orthotopic primary TNBC, and efficiently deliver the miR-708 cargo to reduce lung metastasis. Together, our preclinical findings provide a mechanism-based antimetastatic therapeutic approach for TNBC, with a marked potential to generate miR-708 replacement therapy for high-risk TNBC patients in the clinic. +lncRNA target 30679313 hsa-mir-424 Osteosarcoma Utilizing a high-throughput, genome-wide screen for miRNAs and mRNAs that are differentially regulated in osteosarcoma (OS) cell lines, we report that miR-449a and miR-424, belonging to the miR-34 and miR-16 families, respectively, target the major S/G(2) phase cyclin, cyclin A2 (CCNA2), in a bipartite manner. +lncRNA target 30679313 hsa-mir-4 Osteosarcoma Utilizing a high-throughput, genome-wide screen for miRNAs and mRNAs that are differentially regulated in osteosarcoma (OS) cell lines, we report that miR-449a and miR-424, belonging to the miR-34 and miR-16 families, respectively, target the major S/G(2) phase cyclin, cyclin A2 (CCNA2), in a bipartite manner. In summary, the findings in our study highlight that cyclin A2 repression by miRNAs of the miR-16 and miR-34 families is lost in aggressive OS. +lncRNA target 30679313 hsa-mir-16 Osteosarcoma Utilizing a high-throughput, genome-wide screen for miRNAs and mRNAs that are differentially regulated in osteosarcoma (OS) cell lines, we report that miR-449a and miR-424, belonging to the miR-34 and miR-16 families, respectively, target the major S/G(2) phase cyclin, cyclin A2 (CCNA2), in a bipartite manner. In summary, the findings in our study highlight that cyclin A2 repression by miRNAs of the miR-16 and miR-34 families is lost in aggressive OS. +lncRNA target 30679313 hsa-mir-449a Osteosarcoma Utilizing a high-throughput, genome-wide screen for miRNAs and mRNAs that are differentially regulated in osteosarcoma (OS) cell lines, we report that miR-449a and miR-424, belonging to the miR-34 and miR-16 families, respectively, target the major S/G(2) phase cyclin, cyclin A2 (CCNA2), in a bipartite manner. +other 30679264 hsa-let-7i Ischemia Collectively, our results revealed that let-7i-5p is involved in the regulation of the CM cell cycle and further impacts proliferation, which may offer a new potential therapeutic strategy for cardiac repair after ischemic injury. +other 30679264 hsa-let-7i Myocardial Infarction Supperession of let-7i-5p promoted the recovery of heart function post-myocardial infarction by enhancing E2F2 and CCND2. +genetics_GWAS 30679246 hsa-mir-35 Embryo Loss Here we show that combining feminizing mutations with partial loss of function of the mir-35 family results in enhanced penetrance embryonic lethality that preferentially kills XO animals. +genetics_GWAS 30679246 hsa-mir-35 Death Here we show that combining feminizing mutations with partial loss of function of the mir-35 family results in enhanced penetrance embryonic lethality that preferentially kills XO animals. +genetics_overexpression_promote 30679084 hsa-mir-150 Uterine Cervical Neoplasms Furthermore, we found that SRCIN1 overexpression could obviously inhibit the proliferation and EMT of cervical cancer cells triggered by miR +lncRNA target 30678736 hsa-mir-133a Colorectal Neoplasms CONCLUSIONS Our findings revealed the critical role of CXCR4 in promoting progression of inflammatory colorectal cancer through recruiting immunocytes and enhancing cytoskeletal remodeling by lncRNA XIST/ miR-133a-3p/ RhoA signaling. +genetics_overexpression_promote 30678643 hsa-mir-342 Nasopharyngeal Carcinoma Overexpression of FOXQ1 rescued the inhibitory effects of miR +circulation_biomarker_diagnosis_up 30678416 hsa-mir-1231 Pancreatic Carcinoma Conclusions: The downregulation of exosomal miR-1231 in plasma of pancreatic cancer patients and pancreatic cancer cells suggests that it is related to the initiation and development of PC. +circulation_biomarker_diagnosis_up 30678250 hsa-mir-195 Ischemic Stroke At T0, circulating miRNA5p and -451a were significantly upregulated in both AIS and TIA patients, compared to C. +circulation_biomarker_diagnosis_up 30678250 hsa-mir-451a Ischemic Stroke At T0, circulating miRNA5p and -451a were significantly upregulated in both AIS and TIA patients, compared to C. +other 30678026 hsa-mir-126 Carcinoma, Non-Small-Cell Lung Further investigation into the role of miR-126 as a prognostic marker in early-stage NSCLC is warranted. +other 30678026 hsa-mir-222 Carcinoma, Non-Small-Cell Lung 3p remaining significant for OS. +other 30678026 hsa-mir-22 Carcinoma, Non-Small-Cell Lung 3p remaining significant for OS. +other 30678026 hsa-mir-93 Carcinoma, Non-Small-Cell Lung 3p remaining significant for OS. +transcription factor target 30677405 hsa-mir-1 Stomach Neoplasms It was found that miR-31 is significantly downregulated in GC cell lines. It is therefore concluded that miR-31 acts as a tumor suppressor and may prove essential in the treatment of GC. +circulation_biomarker_diagnosis_ns 30677061 hsa-mir-124 Peripheral Nervous System Diseases The increase in circulating miR-124 correlated with cold allodynia and axonal degeneration in both DRG and sciatic nerve. +circulation_biomarker_diagnosis_up 30676868 hsa-mir-542 Pulmonary Disease, Chronic Obstructive 3p and -5p expression is elevated in COPD patients and may suppress physical performance at least in part by inhibiting mitochondrial and cytoplasmic ribosome synthesis and suppressing protein synthesis. +transcription factor target 30676715 hsa-mir-543 Parkinson Disease 3p can rescue the expression and function of GLT-1 and relieve dyskinesia in the PD model, which suggests that inhibition of miR +lncRNA target 30675310 hsa-mir-543 Liver Neoplasms Inhibition of microRNA-543 expression increased cell proliferation and decreased apoptosis of liver cancer cells. +lncRNA target 30675297 hsa-mir-197 Carcinoma, Hepatocellular 3p/ZIK1 axis may serve as a novel therapeutic target in patients with HCC. +other 30675293 hsa-mir-21 Colonic Neoplasms Expression levels of miR-21 and miR-138 in colorectal cancer and normal adjacent tissues were compared. +lncRNA target 30675293 hsa-mir-138 Colonic Neoplasms miR-21 promotes proliferation of colon cancer cell line SW480, and miR-138 inhibits cell proliferation. +genetics_knock down_suppress 30675291 hsa-mir-744 Prostatic Neoplasms In a recent study, it was demonstrated that miR-744 was overexpressed in prostate tissue from PCa patients when compared with the surrounding tissues, and knockdown of miR-744 resulted in reduced cell growth. +genetics_overexpression_promote 30675287 hsa-mir-21 Carcinoma, Hepatocellular HCC cell migratory and invasive abilities significantly increased because of miR-21 overexpression. +genetics_overexpression_promote 30675286 hsa-mir-140 Colorectal Neoplasms 5p overexpression suppressed cell proliferation and invasion in CRC. +lncRNA target 30675279 hsa-mir-455 Colorectal Neoplasms 5p may target and downregulate PIK3R1 in colorectal cancer. +transcription factor target 30675273 hsa-mir-545 Squamous Cell Carcinoma of Head and Neck In conclusion, the present data demonstrate the tumor suppressive role of miR-545 in OSCC. +lncRNA target 30675266 hsa-mir-885 Osteosarcoma 5p in osteosarcoma, it was determined that beta-catenin, a key component of the Wnt signaling pathway, was a target of miR +genetics_overexpression_promote 30675254 hsa-mir-139 Carcinoma, Hepatocellular The present study determined that overexpression of miR-139 significantly inhibits HCC cell proliferation (P<0.05) and migration (P<0.05), which is largely due to TOP1 downregulation. +genetics_overexpression_promote 30675252 hsa-mir-135a Prostatic Neoplasms The current study investigated the induced overexpression of miR-135a in prostate cancer cell lines to detect its function in prostate cell apoptosis using Hoechst staining and fluorescence-activated cell sorting and examined the expression levels of STAT6 and its DNA binding ability using western blotting and an electrophoretic mobility shift assay. +genetics_overexpression_suppress 30675243 hsa-mir-7 Glioblastoma 5p overexpression reversed the effects of SATB1 on cell migration and invasion in glioblastoma cells. +lncRNA target 30675239 hsa-mir-664 Osteosarcoma The OS cell line SOSP-9607 was selected as the object of study, and miR-664 blank group, miR-664 mimic group, miR-664 inhibitor group, miR-184 blank group, miR-184 mimic group and miR-184 inhibitor group were established through transfection. +lncRNA target 30675239 hsa-mir-184 Osteosarcoma The OS cell line SOSP-9607 was selected as the object of study, and miR-664 blank group, miR-664 mimic group, miR-664 inhibitor group, miR-184 blank group, miR-184 mimic group and miR-184 inhibitor group were established through transfection. +lncRNA target 30675230 hsa-mir-6819 Carcinoma, Hepatocellular 3P may enhance the expression levels of ACTG1 and inhibit the expression levels of TLR3 in alcohol-associated HCC tissues. +lncRNA target 30675230 hsa-mir-6877 Carcinoma, Hepatocellular 3P may enhance the expression levels of ACTG1 and inhibit the expression levels of TLR3 in alcohol-associated HCC tissues. +lncRNA target 30675229 hsa-mir-15b Carcinoma, Hepatocellular Bioinformatically, 225 overlapping genes were selected as prospective target genes of miR-15b-5p in HCC, and profoundly enriched GO terms and KEGG pathway investigation in silico demonstrated that the target genes were associated with prostate cancer, proximal tubule bicarbonate reclamation, heart trabecula formation, extracellular space, and interleukin-1 receptor activity. +genetics_overexpression_promote 30675226 hsa-mir-504 Osteosarcoma The results demonstrated that miR-504 was overexpressed in osteosarcoma tissues and cells. +genetics_overexpression_promote 30675215 hsa-mir-146a Breast Neoplasms Overexpression of miR-146a-5p significantly suppressed the proliferation, invasion and migration of BC MDA-MB-453 and MCF7 cells. +other 30675214 hsa-mir-885 Osteosarcoma 5p could be a promising novel therapeutic biomarker for OS. +other 30675199 hsa-mir-200b Ovarian Neoplasms Upregulation of miR-200b and miR-200c promoted EOC cell death in the presence of cisplatin. +other 30675199 hsa-mir-200c Ovarian Neoplasms Upregulation of miR-200b and miR-200c promoted EOC cell death in the presence of cisplatin. +other 30675129 hsa-mir-21 Pancreatic Carcinoma Our work revealed a novel regulatory mechanism of the CASC2/miR-21/PTEN axis that may be important in pancreatic cancer. +tissue_expression_up 30674954 hsa-mir-182 Pruritus Importantly, Itch deficiency reduced Foxo1 mRNA expression by up-regulating JunB-mediated miR-182. +other 30674952 hsa-mir-141 Prostatic Neoplasms To conclude, high expression of miR-141 appears associated with increased risk of biochemical PC recurrence. +genetics_overexpression_promote 30674565 hsa-mir-144 Osteosarcoma Functionally, RhoA with or without ROCK1 co-overexpression resulted a rescue phenotype on miR-144 inhibited cell growth, migration, and invasion abilities whereas individual overexpression of ROCK1 had no statistical significance compared with controls in miR +transcription factor target 30674440 hsa-mir-652 Atherosclerosis 3p, which is upregulated in human and murine atherosclerotic plaques, suppresses expression of the endothelial repair gene Ccnd2, thereby enhancing atherosclerotic lesion formation. +circulation_biomarker_diagnosis_ns 30673918 hsa-mir-122 Diabetic Retinopathy To examine whether serum miRNAs show altered levels at different stages of diabetic retinopathy, seven specific miRNA candidates (miR +other 30673848 hsa-mir-181a Rhinitis, Allergic The intracellular miR-155 and miR-181a levels may serve as predictors of disease severity in childhood AR. +other 30673848 hsa-mir-155 Rhinitis, Allergic The intracellular miR-155 and miR-181a levels may serve as predictors of disease severity in childhood AR. +lncRNA target 30673803 hsa-mir-19a Endometritis CONCLUSION: We demonstrated that miR-19a has anti-inflammatory effects and mediates the negative regulation of the NF-kappaB Pathway in LPS-induced endometritis by targeting TBK1. +other 30673615 hsa-mir-223 Asthma, Allergic After the induction of allergic airway inflammation, miRNAs selectively expressed by immune cells, including miR-223 and miR-142a, increased and hematopoietic-cell-derived EVs also increased >2-fold. +other 30673615 hsa-mir-142a Asthma, Allergic After the induction of allergic airway inflammation, miRNAs selectively expressed by immune cells, including miR-223 and miR-142a, increased and hematopoietic-cell-derived EVs also increased >2-fold. +other 30672723 hsa-mir-132 Diabetes Mellitus, Type 2 Interestingly, several islet microRNAs (miRNAs) are upregulated in T2D, including miR-132. +lncRNA target 30672444 hsa-mir-338 salivary gland adenoid cystic carcinoma The proliferation, migration, and invasion of SACC-83 cells also decreased after hsa_circ_0059655 knock-downed.Taken together, the circRNAs derived from PYGB may regulate the tumorigenesis and development of SACC through competing with miR +lncRNA target 30672441 hsa-mir-22 Alzheimer Disease The expression of miR-22 in the hippocampus of patients with AD inhibits neuronal apoptosis, thereby improving learning and memory dysfunction. +genetics_overexpression_suppress 30672438 hsa-mir-494 Stomach Neoplasms overexpressed gastric cancer cells. +lncRNA target 30672051 hsa-mir-204 Angelman Syndrome In summary, our study identified the role of the MEG3/miR-204/CDKN2A pathway in Raw264.7 cells treated with ox-LDL, revealed a novel regulatory pathway in AS and indicated potential novel characteristic biomarkers and therapeutic targets for AS. +other 30671754 hsa-mir-214 Aortic Valve Disease This implies that miR-214 may have a protective role in stretch-induced calcific AV disease. +lncRNA target 30671469 hsa-mir-548b Carcinoma, Hepatocellular miR-548b-3p regulates proliferation, apoptosis and mitochondrial function by targeting CIP2A in HCC. +other 30670982 hsa-mir-382 Breast Neoplasms 5p) were subsequently validated using real-time quantitative reverse transcription-polymerase chain reaction (RT-qPCR) in a cohort of 53 breast cancer, 40 benign lesions and 38 normal cases. +other 30670982 hsa-mir-192 Breast Neoplasms 5p) were subsequently validated using real-time quantitative reverse transcription-polymerase chain reaction (RT-qPCR) in a cohort of 53 breast cancer, 40 benign lesions and 38 normal cases. +other 30670982 hsa-mir-1273g Breast Neoplasms 5p) were subsequently validated using real-time quantitative reverse transcription-polymerase chain reaction (RT-qPCR) in a cohort of 53 breast cancer, 40 benign lesions and 38 normal cases. +other 30670982 hsa-mir-152 Breast Neoplasms 5p) were subsequently validated using real-time quantitative reverse transcription-polymerase chain reaction (RT-qPCR) in a cohort of 53 breast cancer, 40 benign lesions and 38 normal cases. +other 30670982 hsa-mir-574 Breast Neoplasms 5p) were subsequently validated using real-time quantitative reverse transcription-polymerase chain reaction (RT-qPCR) in a cohort of 53 breast cancer, 40 benign lesions and 38 normal cases. +other 30670982 hsa-mir-22 Breast Neoplasms 5p) were subsequently validated using real-time quantitative reverse transcription-polymerase chain reaction (RT-qPCR) in a cohort of 53 breast cancer, 40 benign lesions and 38 normal cases. +other 30670982 hsa-mir-21 Breast Neoplasms 5p) were subsequently validated using real-time quantitative reverse transcription-polymerase chain reaction (RT-qPCR) in a cohort of 53 breast cancer, 40 benign lesions and 38 normal cases. +other 30670982 hsa-mir-222 Breast Neoplasms 5p) were subsequently validated using real-time quantitative reverse transcription-polymerase chain reaction (RT-qPCR) in a cohort of 53 breast cancer, 40 benign lesions and 38 normal cases. +other 30670982 hsa-mir-221 Breast Neoplasms 5p) were subsequently validated using real-time quantitative reverse transcription-polymerase chain reaction (RT-qPCR) in a cohort of 53 breast cancer, 40 benign lesions and 38 normal cases. +other 30670982 hsa-mir-451a Breast Neoplasms 5p) were subsequently validated using real-time quantitative reverse transcription-polymerase chain reaction (RT-qPCR) in a cohort of 53 breast cancer, 40 benign lesions and 38 normal cases. +circRNA target 30670716 hsa-mir-124 Reperfusion Injury, Hepatic Ischemia Our study is the first to show that circRNAs are closely related to hepatic I/R injury and IPO and suggests that targeting mmu_circRNA_005186-miR3p-Epha2 pathway might attenuate hepatic I/R injury. +circRNA target 30670688 hsa-mir-200c Breast Neoplasms Importantly, hsa_circ_001783 promoted progression of breast cancer cells via sponging miR-200c-3p. +lncRNA target 30670679 hsa-mir-22 Stomach Neoplasms CONCLUSIONS LncRNA MIR22HG suppressed gastric cancer progression through attenuating NOTCH2 signaling. +circulation_biomarker_diagnosis_up 30670062 hsa-mir-1307 Ovarian Neoplasms CONCLUSION: Our results suggest that serum exosomal miR-1307 and miR-375 could serve as potential tumor biomarkers to improve diagnostic efficiency for OC. +circulation_biomarker_diagnosis_up 30670062 hsa-mir-375 Ovarian Neoplasms CONCLUSION: Our results suggest that serum exosomal miR-1307 and miR-375 could serve as potential tumor biomarkers to improve diagnostic efficiency for OC. +circulation_biomarker_diagnosis_ns 30670045 hsa-mir-92a Coronary Disease CONCLUSION: An elevated circulating miR-92a level was associated with an increased risk of ACS in CHD patients with T2DM. +circulation_biomarker_diagnosis_ns 30670045 hsa-mir-92a Diabetes Mellitus CONCLUSION: An elevated circulating miR-92a level was associated with an increased risk of ACS in CHD patients with T2DM. +circulation_biomarker_diagnosis_ns 30670045 hsa-mir-92a Acute Coronary Syndrome CONCLUSION: An elevated circulating miR-92a level was associated with an increased risk of ACS in CHD patients with T2DM. +genetics_overexpression_promote 30669957 hsa-mir-506 Osteosarcoma 3p mimics transfection, and restored when SPHK1 was overexpressed simultaneously. +other 30669802 hsa-mir-433 Stomach Neoplasms Conclusion: ERK plays an important role in the apoptosis of gastric cancer cells induced by miR-433. +transcription factor target 30669689 hsa-mir-351 Atherosclerosis CONCLUSIONS: We introduce new potential mediators of ATH progression (CD34 cell-clusters, miR-351), and propose a new mechanism of miRNA action, linked to a cryptic splicing site in the target-host gene, that would regulate the differential accession of miRNAs to their cognate binding sites. +genetics_overexpression_suppress 30669553 hsa-mir-6556 Prostatic Neoplasms, Castration-Resistant 5p are significantly overexpressed in castration-resistant prostate cancer (CRPC) cell lines, indicating that their gain may be an early event in PCa progression. +genetics_overexpression_suppress 30669553 hsa-mir-6756 Prostatic Neoplasms, Castration-Resistant 5p are significantly overexpressed in castration-resistant prostate cancer (CRPC) cell lines, indicating that their gain may be an early event in PCa progression. +genetics_overexpression_suppress 30669553 hsa-mir-4719 Prostatic Neoplasms, Castration-Resistant 5p are significantly overexpressed in castration-resistant prostate cancer (CRPC) cell lines, indicating that their gain may be an early event in PCa progression. +lncRNA target 30669342 hsa-mir-222 Viral Myocarditis Our findings suggest that ADAR1p150 plays a key role in complexing with Dicer and promoting the expression of miRNA-222, the latter of which suppresses the expression of the target gene PTEN during VMC. +genetics_knock down_suppress 30668962 hsa-mir-3960 Osteoporosis CONCLUSION: Our findings indicate that UCB-EVs ameliorate age-related bone loss by stimulating bone formation and inhibiting bone resorption, and miR-3960 mediated the osteogenic effect of UCB-EVs on BMSCs. +genetics_overexpression_promote 30668544 hsa-mir-223 Carcinoma, Renal Cell In renal cancer cells, overexpression of miR +other 30668358 hsa-mir-129 Carcinoma, Non-Small-Cell Lung Chidamide-induced ROS accumulation and miR3p-dependent cell cycle arrest in non-small lung cancer cells. +genetics_knock down_promote 30668319 hsa-mir-6809 Carcinoma, Hepatocellular 5p suppressed HCC cell growth, while knockdown of miR +transcription factor target 30668175 hsa-mir-210 Coronary Artery Disease CONCLUSIONS: miR-210 was a hypoxia responsive element in CSCs, and its up-regulation inhibited apoptosis of CSCs and promoted their migration under hypoxic condition, through regulating its target genes Casp8ap2/Caspase 8 and PTPN2, which may provide a new strategy for cell therapy of ischemic heart disease. +exosome 30667374 hsa-mir-34a Metabolic Diseases Furthermore, increased miR-34a expression in visceral fat of overweight/obese subjects correlated negatively with reduced Klf4 expression, but positively with the parameters of insulin resistance and metabolic inflammation. In summary, miR-34a was a key component of adipocyte-secreted exosomal vesicles that transmitted the signal of nutrient overload to the adipose-resident macrophages for exacerbation of obesity-induced systemic inflammation and metabolic dysregulation. +exosome 30667374 hsa-mir-34a Obesity Furthermore, increased miR-34a expression in visceral fat of overweight/obese subjects correlated negatively with reduced Klf4 expression, but positively with the parameters of insulin resistance and metabolic inflammation. In summary, miR-34a was a key component of adipocyte-secreted exosomal vesicles that transmitted the signal of nutrient overload to the adipose-resident macrophages for exacerbation of obesity-induced systemic inflammation and metabolic dysregulation. +genetics_knock down_promote 30666838 hsa-mir-206 Osteosarcoma The effects of miR-206 overexpression on OS cells were reversed by PAX3 or MET overexpression, but only partially attenuated by HGF treatment. +lncRNA target 30666836 hsa-mir-182 Breast Neoplasms Interestingly, PTEN was indicated as a target of miR +lncRNA target 30666657 hsa-mir-22 Sepsis CONCLUSION: TapSAKI was elevated in urine derived sepsis-induced kidney injury, and promoted HK-2 cell apoptosis and inflammatory response through miR-22/PTEN/TLR4/NF-kappaB pathway. +lncRNA target 30666657 hsa-mir-22 Diabetic Nephropathies CONCLUSION: TapSAKI was elevated in urine derived sepsis-induced kidney injury, and promoted HK-2 cell apoptosis and inflammatory response through miR-22/PTEN/TLR4/NF-kappaB pathway. +circRNA target 30666650 hsa-mir-199b Colorectal Neoplasms Mechanistically, circ-NSD2 acted as a sponge for the tumour suppressor miR-199b-5p and activated DDR1 (discoidin domain receptor tyrosine kinase 1) and JAG1 (Jagged 1) genes, which synergistically helped with cell-matrix interaction, migration and metastasis of CRC cells. Taken together, our findings highlight a novel oncogenic function of circ-NSD2 and uncover a key mechanism for the circ-NSD2/miR-199b-5p/DDR1/JAG1 axis in CRC metastasis, which may serve as a prognostic factor and therapeutic target for antimetastatic therapy in CRC patients. +genetics_knock down_promote 30666648 hsa-mir-665 Heart Failure Following the establishm;ent of the rat models of HF, the functional role miR-665 in HF was determined using an ectopic expression and knockdown experiments. +genetics_GWAS 30666638 hsa-mir-25 Neonatal Sepsis CONCLUSION: The single-nucleotide polymorphism (SNP; rs41274221) in miR-25 is associated with the risk of sepsis in newborns. +lncRNA target 30666161 hsa-mir-30 Uterine Cervical Neoplasms Moreover, tumor suppressor p53 was identified as the direct target of miR +genetics_overexpression_suppress 30666160 hsa-mir-4458 Carcinoma, Non-Small-Cell Lung Overexpression of miR-4458 strongly reduced the proliferation and migration in NSCLC cell lines. +lncRNA target 30666158 hsa-mir-181a Colorectal Neoplasms CONCLUSION: Taken together, these results demonstrated that SNHG6 plays a crucial role in CRC progression via miR-181a-5p/E2F5 axis. +circulation_biomarker_diagnosis_down 30666131 hsa-mir-195 Carcinoma, Hepatocellular RESULTS: The expression of miR-195 was downregulated in HCC cells and serum of patients compared to the controls (all P<0.05). +other 30666128 hsa-mir-582 Urinary Bladder Neoplasms 5p-ATG7-autophagy axis. +transcription factor target 30665445 hsa-mir-135b Breast Neoplasms CONCLUSION: Our results highlight the potential of miR-135b-5p as a target for treating AGR2-expressing breast cancer with doxorubicin-resistance. +genetics_overexpression_promote 30664712 hsa-mir-483 Nasopharyngeal Carcinoma In this study, we show that the overexpression of miR +other 30664688 hsa-mir-21 Prostatic Neoplasms In turn, this metabolic-based CAF-immunomodulated environment exerts a pro-invasive effect on prostate cancer cells, by activating a previously unexplored miR21/TLR8 axis that sustains cancer malignancy. +lncRNA target 30664260 hsa-mir-744 psoriasis 1 3p regulated the proliferation and differentiation of keratinocytes through targeting KLLN in psoriasis. +genetics_overexpression_promote 30664191 hsa-mir-98 Retinoblastoma Overexpression of miR98 was suggested to suppress RB cell growth, migration and invasion. +genetics_knock down_promote 30664185 hsa-mir-653 Carcinoma, Hepatocellular ITGB1 overexpression reversed the inhibitory effects of miR3653 on the growth, metastasis and EMT of HCCLM3 cells. +other 30664182 hsa-mir-162 Cleft Lip A negative correlation between miR1623p and PDPK1 in cleft lip tissues was observed. +transcription factor target 30664182 hsa-mir-162 Noonan syndrome-like disorder with loose anagen hair However, the association between miR1623p and 3phosphoinositidedependent protein kinase1 (PDPK1) in nonsyndromic cleft lip (NSCL) remains unclear. These results indicate that miR1623p may inhibit cell proliferation and migration, and promote apoptosis in MPMCs through repression of PDPK1 and may be a potential target for future clinical prevention and treatment of NSCL. +other 30664182 hsa-mir-162 Otofaciocervical Syndrome However, the association between miR1623p and 3phosphoinositidedependent protein kinase1 (PDPK1) in nonsyndromic cleft lip (NSCL) remains unclear. +genetics_overexpression_promote 30664171 hsa-mir-671 Carcinoma, Non-Small-Cell Lung Furthermore, rescue experiments demonstrated that the restoration of CCND2 may significantly reverse the suppressive roles of miR6713p overexpression on NSCLC cell proliferation and invasion. +genetics_overexpression_suppress 30664167 hsa-mir-663a Colonic Neoplasms miR663a overexpression inhibited the proliferation and migration/invasion of CC cells in vitro, and also tumor growth and metastasis of CC cells in vivo. +transcription factor target 30664157 hsa-mir-1 Osteoarthritis In conclusion, the data indicated that miR31 promoted chondrocyte viability and migration by directly targeting CXCL12, which provided evidence for CXCL12 as a potential target in OA therapy. +genetics_overexpression_promote 30664155 hsa-mir-9 Carcinoma, Hepatocellular In the present study, miR95p was revealed to be overexpressed in HCC as a novel upstream gene of Klf4. +circulation_biomarker_diagnosis_up 30664152 hsa-mir-122 Lichen Planus, Oral The results from the microarray and RTqPCR analyses demonstrated that the expression levels of miR122 and miR199 were significantly decreased in the peripheral blood mononuclear cells (PBMCs) collected from the OLP group compared with the control group. +circulation_biomarker_diagnosis_up 30664152 hsa-mir-199 Lichen Planus, Oral The results from the microarray and RTqPCR analyses demonstrated that the expression levels of miR122 and miR199 were significantly decreased in the peripheral blood mononuclear cells (PBMCs) collected from the OLP group compared with the control group. +lncRNA target 30663767 hsa-mir-671 Glioblastoma 5p/ CDR1 pathway modulates the development of GBM, and this pathway might be a promising target for the development of therapeutics for GBM. +genetics_knock down_suppress 30662936 hsa-mir-598 Ovarian Neoplasms To elucidate the role of miRNAs in URI-induced ovarian cancer, miR-598 and URI were overexpressed in the SKOV3 ovarian cancer cell line. The results showed that the expression of miR-598 inhibited the proliferation, invasion, and migration of ovarian cancer cells by targeting URI. +genetics_GWAS 30662901 hsa-mir-122 Carcinoma, Hepatocellular Our results suggest that SNP of rs1135519 modulates miR-122 expression and contributes to the genetic susceptibility of HCC, either independently or together with rs9966765 in miR-122. +lncRNA target 30662812 hsa-mir-338 Prostatic Neoplasms Reintroduction of RAB23 attenuated the inhibitory effects of miR +transcription factor target 30662808 hsa-mir-26b Colorectal Neoplasms Meanwhile, we showed that miR-26b improved sensibility of colorectal cancer cells to 5-FU in vitro and enhanced the potency of 5-FU in the inhibition of tumor growth in vivo. +lncRNA target 30662807 hsa-mir-485 Glioma Mechanistic studies revealed that restoring the expression of PAX3 alleviated miR +lncRNA target 30662805 hsa-mir-186 Osteosarcoma 5p/TBL1XR1 may be a novel therapeutic candidate target in osteosarcoma treatment. +genetics_knock down_promote 30662799 hsa-mir-203a Colorectal Neoplasms In this study, gain and loss-of-function assays showed that miR-203a-3p promotes colorectal cancer cell proliferation, colony formation and migration and invasion by targeting PDE4D. +exosome 30662677 hsa-mir-208a Cardiomyopathies Cardiomyocytes participate in cardiac fibrosis by secreting exosomes containing miR-208a, which increases fibroblast proliferation and differentiation into myofibroblasts. +lncRNA target 30662652 hsa-mir-335 Myocardial Reperfusion Injury Thus, miR-335 may be a new therapeutic target for the treatment of MIRI. +lncRNA target 30662643 hsa-mir-4262 Colonic Neoplasms Together, our study suggests that aberrantly expressed miR-4262 may affect cell apoptosis and proliferation of human colon cancer cells via GALNT4, which appears to be a promising therapeutic target for colon cancer. +transcription factor target 30662618 hsa-mir-145 Myocardial Reperfusion Injury Here, we aimed to examine whether miRNA-145 (miR-145) is involved in FGF21 protection against myocardial I/R injury through angiopoietin-2 (Angpt2) and autophagy. CONCLUSION: FGF21 protects myocardial cells against I/R injury by promoting an increase in miR-145 levels and autophagy while inhibiting Angpt2 expression, suggesting a novel therapeutic strategy for protecting against myocardial I/R injury. +genetics_overexpression_promote 30662606 hsa-mir-106a Squamous Cell Carcinoma of Head and Neck Importantly, overexpression of MeCP2 eliminated the effects of miR-106a* overexpression in OSCC cells and silencing of MeCP2 recapitulated the cellular and molecular effects observed with miR-106a* overexpression. +transcription factor target 30662604 hsa-mir-557 Carcinoma, Pancreatic Ductal In addition, our findings suggested that EFNB2 contributes to PDAC progression by acting as the target gene of miR-557. +lncRNA target 30662595 hsa-mir-200c Glioma Hence, ZEB1-AS1 directly regulated miR-200c/141 in glioma cells and relieved the inhibition of ZEB1 caused by miR-200c/141. +circulation_biomarker_diagnosis_ns 30662567 hsa-mir-141 Breast Neoplasms Meanwhile, the performance of multiplexing was estimated by simultaneous detection of miR-21 and miR-141, and the method also allowed for miR-21 detection in breast cancer blood samples. +circulation_biomarker_diagnosis_ns 30662567 hsa-mir-21 Breast Neoplasms Meanwhile, the performance of multiplexing was estimated by simultaneous detection of miR-21 and miR-141, and the method also allowed for miR-21 detection in breast cancer blood samples. +transcription factor target 30662562 hsa-mir-103a Multiple Myeloma We experimentally verified that MM-EVs inhibited BM-MSC osteogenesis, induced elevated expression of miR-103a-3p inhibiting osteogenesis in BM-MSCs, and increased cell viability and interleukin-6 secretion in MM cells. +other 30662548 hsa-mir-200c Breast Neoplasms Conclusions: Our findings indicated that high miRNA-200c expression was a promising biomarker for patient survival and disease progression in malignant tumors, especially in breast cancer and endometrial cancer. +other 30662548 hsa-mir-200c Endometrial Neoplasms In addition, a significantly unfavorable OS (pooled HR = 2.69, 95% CI: 1.49-4.85) and (pooled HR = 2.66, 95% CI: 1.07-6.59) associated with up-regulated miRNA-200c expression were observed in breast cancer and endometrial cancer, respectively. Conclusions: Our findings indicated that high miRNA-200c expression was a promising biomarker for patient survival and disease progression in malignant tumors, especially in breast cancer and endometrial cancer. +lncRNA target 30662538 hsa-mir-98 Leukemia, Myeloid, Acute It has been demonstrated that microRNA-98 (miR-98) is dysregulated in multiple types of solid tumors, but its expression and impact in acute myeloid leukemia (AML) is unclear. +circulation_biomarker_diagnosis_ns 30662524 hsa-mir-320d Colorectal Neoplasms Thereafter, circulating miR-1290 and miR-320d were selected to further investigate their potential for early diagnosis of CRC. +circulation_biomarker_diagnosis_ns 30662524 hsa-mir-1290 Colorectal Neoplasms Results: After integrated analysis of GEO datasets, we discovered miR-1290 and miR-320d were dysregulated in colorectal adenoma and adenocarcinoma tissues, and circulating miR-1290 and miR-320d in CRC patients were tumor-derived. +circulation_biomarker_diagnosis_ns 30662356 hsa-mir-199b limb ischemia Consequently, we found that the transfer of hiPSC-ECs enriched with miR-199b-5p significantly enhanced micro-vessel density and blood perfusion in ischemic limbs in vivo. +other 30662346 hsa-mir-375 Newcastle Disease We discovered that the miR-375 is significantly upregulated in Newcastle disease virus (NDV)-infected chicken embryonic visceral tissues using a small RNA sequencing approach. +other 30662334 hsa-mir-20 Hyperplasia However, the role of miR-320 in vascular smooth muscle cells (VSMCs) and proliferative vascular diseases is still completely unclear. +other 30662334 hsa-mir-20 Vascular Diseases However, the role of miR-320 in vascular smooth muscle cells (VSMCs) and proliferative vascular diseases is still completely unclear. These novel findings implied that the regulation of NRP1 expression by miR-320 has important significance in the early diagnosis and treatment of proliferation vascular diseases. +other 30662333 hsa-mir-34a Upper Tract Urothelial Carcinoma Using the clinical outcome prediction database, low expression of SLIT3 was found to be a prognostic predictor of poor survival in urothelial cancer, and a novel miRNA, miR-34a-5p, was a potential regulator of SLIT3, which may infer the potential role of miR-34a-5p-SLIT3 regulation in the altered tumor microenvironment in UTUC. +lncRNA target 30661902 hsa-mir-152 Osteosarcoma CONCLUSION: We showed thatlncRNA PVT1 played a contributory role in chemoresistance of osteosarcoma cells through c-MET/PI3K/AKT pathway activation, which was largely dependent on miR-152. +other 30660934 hsa-mir-9 Uterine Cervical Neoplasms 3p as hypoxia biomarker in cervical cancer. +other 30660934 hsa-mir-210 Uterine Cervical Neoplasms 3p as hypoxia biomarker in cervical cancer. +genetics_overexpression_promote 30660685 hsa-mir-328a Erectile Dysfunction The siRNA against lncRNA-MIAT, miR-328a-5p mimic and overexpression vector of LPL were transfected to investigate the specific effects of miR-328a-5p, lncRNA-MIAT and LPL on ED in diabetes. +genetics_overexpression_promote 30660685 hsa-mir-328a Diabetes Mellitus The siRNA against lncRNA-MIAT, miR-328a-5p mimic and overexpression vector of LPL were transfected to investigate the specific effects of miR-328a-5p, lncRNA-MIAT and LPL on ED in diabetes. +other 30660651 hsa-mir-140 lung squamous cell carcinoma Collectively, our study suggests the prognostic and therapeutic roles of miR3p and BRD9 axis in squamous cell lung cancer. +genetics_overexpression_promote 30659947 hsa-mir-1 Carcinoma, Non-Small-Cell Lung Lastly, we verified that overexpression of MIR31HG effectively reverses miR +circulation_biomarker_diagnosis_up 30659946 hsa-mir-210 Pre-Eclampsia RESULTS The level of hsa-miR-210 was significantly higher in PE placentas, which could cause a minor increase of exosomal and a high elevation of Ago-bound miR-210 in circulation. +genetics_overexpression_suppress 30659647 hsa-mir-98 Neuralgia Overexpression of miR-98 inhibited neuropathic pain progression, including mechanical and thermal hyperalgesia. +lncRNA target 30659641 hsa-mir-152 Endometrial Neoplasms Progesterone ameliorates the endometrial polyp by modulating the signaling pathway of Wnt and -catenin via regulating the expression of H19 and miR-152. +other 30659640 hsa-mir-3680 Esophageal Squamous Cell Carcinoma In conclusion, our current studies have been revealing that circ-PRKCI/miR3p/AKT3 regulatory network plays an important role in esophageal squamous cell carcinoma and that provide new insights into the pathogenesis of esophageal squamous cell carcinoma. +circulation_biomarker_diagnosis_ns 30659233 hsa-mir-126 Pre-Eclampsia We assessed GATA2 and miR126 in preeclampsia. Whole blood circulating GATA2 mRNA and miR126 expression were significantly decreased in women with established early-onset preeclampsia compared to gestation-matched controls (p=0.002, p<0.0001, respectively). +lncRNA target 30659020 hsa-mir-2392 Ehlers-Danlos Syndrome, musculocontractural type 1 Here we report that the mitomiR-2392 regulates chemoresistance in tongue squamous cell carcinoma (TSCC) cells by reprogramming metabolism via downregulation of oxidative phosphorylation and upregulation of glycolysis. A retrospective analysis of TSCC patient tumors revealed a significant association of miR-2392 and regulated mitochondrial gene expression with chemosensitivity and overall survival. +lncRNA target 30659020 hsa-mir-2392 Squamous Cell Carcinoma of Head and Neck Here we report that the mitomiR-2392 regulates chemoresistance in tongue squamous cell carcinoma (TSCC) cells by reprogramming metabolism via downregulation of oxidative phosphorylation and upregulation of glycolysis. +other 30658692 hsa-mir-276 Dengue miR-1767 and miR3p enhanced dengue virus replication in C6/36 cells, and miR-4448 reduced dengue virus replication. +other 30658692 hsa-mir-4448 Dengue miR-1767 and miR3p enhanced dengue virus replication in C6/36 cells, and miR-4448 reduced dengue virus replication. +other 30658692 hsa-mir-1767 Dengue miR-1767 and miR3p enhanced dengue virus replication in C6/36 cells, and miR-4448 reduced dengue virus replication. +transcription factor target 30658681 hsa-mir-190 Breast Neoplasms miR-190 inhibited Wnt/beta-catenin signaling by targeting SOX9, and its expression inversely correlated with that of SOX9 in breast cancer samples. +lncRNA target 30658617 hsa-mir-10b Obesity Manipulation of miR-10b levels also inversely affected the mRNA levels of miR-10b targets BCL2L11, PIEZO1 and NCOR2. +lncRNA target 30658617 hsa-mir-10b Breast Neoplasms Manipulation of miR-10b levels also inversely affected the mRNA levels of miR-10b targets BCL2L11, PIEZO1 and NCOR2. +other 30658492 hsa-mir-146b Arthritis, Psoriatic Candidate miRNAs related to monocyte activation (miR-146a-5p, miR-146b-5p and miR5p) were measured in circulatory CD14(+) monocytes collected from 34 PsA patients, 17 psoriasis without arthritis (PsO) patients, and 34 normal controls (NCs). +circulation_biomarker_diagnosis_ns 30658492 hsa-mir-146a Arthritis, Psoriatic More importantly, after clinical improvement using biologics, the increased miR-146a-5p expression in CD14(+) monocytes from PsA patients was selectively abolished, and associated with blood CRP level. +other 30658492 hsa-mir-155 Arthritis, Psoriatic Candidate miRNAs related to monocyte activation (miR-146a-5p, miR-146b-5p and miR5p) were measured in circulatory CD14(+) monocytes collected from 34 PsA patients, 17 psoriasis without arthritis (PsO) patients, and 34 normal controls (NCs). +other 30658394 hsa-mir-1224 Brain Injuries, Traumatic Additionally, we showed that miRNA-1224 up-regulated in bone marrow-derived EVs cargo of TBI. +other 30658394 hsa-mir-1224 Osteoporosis Additionally, we showed that miRNA-1224 up-regulated in bone marrow-derived EVs cargo of TBI. +other 30658207 hsa-mir-378 Attention Deficit Disorder with Hyperactivity 3p and miR378 levels. +other 30658207 hsa-mir-142 Attention Deficit Disorder with Hyperactivity 3p and miR378 levels. +lncRNA target 30658076 hsa-mir-125a Pulmonary Fibrosis Ectopic miR-125a-3p expression with chemotherapy attenuated silica-induced pulmonary fibrosis. Taken together, miR-125a-3p is involved in fibrosis pathogenesis by fibroblast activation, suggesting that targeting miR-125a-3p/Fyn/STAT3 signaling pathway could be a potential therapeutic approach for pulmonary fibrosis. +lncRNA target 30658067 hsa-mir-29c Carcinoma, Endometrioid In addition, we also identified that microRNA-29c-3p (a tumor suppressor) was significantly lower in the EC cells and linked to the low PTX sensitivity of EC. Silencing of KDM5B led to the reversal of PTX resistance through miR-29c-3p/KDM5B pathway in EC. +lncRNA target 30657980 hsa-mir-214 Triple Negative Breast Neoplasms We validated in cell lines the miR-199/miR-214 as a novel cluster of miRNAs promoting the triple negative breast cancer (TNBC) phenotype through its control of proliferation and EMT. +lncRNA target 30657980 hsa-mir-199 Triple Negative Breast Neoplasms We validated in cell lines the miR-199/miR-214 as a novel cluster of miRNAs promoting the triple negative breast cancer (TNBC) phenotype through its control of proliferation and EMT. +exosome 30657854 hsa-mir-126 Retinitis PURPOSE: In this study, we aim to investigate whether mesenchymal stem cell (MSC)-derived exosomes (MSC-Exos) could regulate hyperglycemia-induced retinal inflammation by transferring microRNA-126 (miR-126). CONCLUSIONS: miR-126 expression in MSC-Exos reduces hyperglycemia-induced retinal inflammation by downregulating the HMGB1 signaling pathway. +lncRNA target 30657727 hsa-mir-21 Kidney Diseases Previously, we found that a 5/6th nephrectomy model of CKD leads to an upregulation of miR5p in the left ventricle, targeting peroxisome proliferator-activated receptor-alpha and altering the expression of numerous transcripts involved with fatty acid oxidation and glycolysis. +circulation_biomarker_prognosis_down 30657585 hsa-mir-124 Glioma Plasma miR-124 expression significantly associated with Karnofsky Performance Status (KPS) score (p<0.05) and WHO grade (p<0.05) in glioma plasma. +lncRNA target 30657584 hsa-mir-31 Glioblastoma CONCLUSIONS: Our findings suggested that GAPLINC served as an oncogenic lncRNA in GBM through negative modulation of miR3p, providing a novel treatment targeting for GBM. +lncRNA target 30657566 hsa-mir-130a Glioma PATIENTS AND METHODS: Quantitative Reverse Transcription-Polymerase Chain Reaction (qRT-PCR) was used to determine the levels of HOMEOBOX A11 antisense RNA (HOXA11-AS) and miR-130a-5p in glioma tissues and cell lines. CONCLUSIONS: Our results demonstrate that HOXA11-AS regulates the growth and metastasis of glioma by targeting the miR-130a-5p-HMGB2 signaling axis. +lncRNA target 30657565 hsa-mir-299 Thyroid Neoplasms 3p could inhibit cell proliferation and cell cycle progression, whereas remarkably promote cell apoptosis in TC cell lines. +lncRNA target 30657563 hsa-mir-26a Squamous Cell Carcinoma of Head and Neck MATERIALS AND METHODS: Tu686 Squamous cell carcinoma of head and neck (SCCHN) cell strains were divided into the miR-26a group, miR-NC group, co-transfection group and blank control group. CONCLUSIONS: miR-26a may reduce the expression level of SMAD1, affect the expression of EMT-related proteins, inhibit the EMT function of Tu686 cells of squamous cell carcinoma of head and neck, and inhibit the invasion of them. +lncRNA target 30657562 hsa-mir-629 Nasopharyngeal Carcinoma MircoRNA-629 promotes proliferation, invasion and migration of nasopharyngeal carcinoma through targeting PDCD4. +genetics_overexpression_promote 30657560 hsa-mir-610 Squamous Cell Carcinoma of Head and Neck Functionally, the overexpression of miR-610 significantly suppressed OSCC cells proliferation, migration, invasion and EMT process. +lncRNA target 30657558 hsa-mir-2016 Stomach Neoplasms Up-regulating miR-2016 expression can weaken the proliferation of drug-resistant gastric cancer cells, facilitate cell apoptosis and decrease DDP resistance via targeted inhibition of MAPK3 expression. +lncRNA target 30657556 hsa-mir-409 Liver Neoplasms CONCLUSIONS: Highly-expressed microRNA-409 can down-regulate the Jak-Stat signaling pathway and inhibit cell proliferation to slow down the progression of liver cancer. +lncRNA target 30657555 hsa-mir-16 Carcinoma, Hepatocellular 5p suppressed invasion and migration of HCC cells, mechanically by directly targeting and inhibiting IGF1R protein expression. +genetics_overexpression_promote 30657551 hsa-mir-146a Osteosarcoma Overexpression of lncSNHG16 downregulated the expression of microRNA-146a-5p in 143B and MNNG/HOS cells. +transcription factor target 30657550 hsa-mir-32 Uterine Cervical Neoplasms 5p/HOXB8 axis might serve as potential target for the clinical diagnosis and treatment of CCa. +exosome 30657546 hsa-mir-133b Spinal Cord Injuries CONCLUSIONS: We showed that exosomes derived from miR-133b-modified ADSCs can significantly promote the recovery of neurological function of SCI animals through affecting the signaling pathway related to axon regeneration and expressions of NF, GAP-43, GFAP and MBP. +genetics_overexpression_promote 30657545 hsa-mir-152 Spinal Cord Injuries Subsequently, miR-152 was overexpressed and the levels of inflammation and c-jun after spinal cord injury were detected by Western blot. +genetics_overexpression_promote 30657544 hsa-mir-219 Spinal Cord Injuries CONCLUSIONS: Overexpressed miR +transcription factor target 30657543 hsa-mir-339 Osteoporosis OBJECTIVE: It was the aim of this study to investigate whether miR-339 may affect osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) by targeting DLX5, thereby alleviating osteoporosis. CONCLUSIONS: Down-regulation of miR-339 can promote osteogenic differentiation of BMSCs by targeting DLX5, thereby relieving osteoporosis. +lncRNA target 30657542 hsa-mir-518b Placenta Accreta OBJECTIVE: To investigate the expression of micro ribonucleic acid miR-518b and its regulatory role in the pathogenesis of placenta accreta. CONCLUSIONS: The high expression of miR-518b may lead to the development of placenta accreta through upregulating the transcription and protein expression of downstream VEGF and OPN, providing insights for the future therapy against the pathogenesis of placenta accreta. +circRNA target 30657346 hsa-mir-4443 Breast Neoplasms CONCLUSION: CircASS1 suppresses invasion and migration capacity of breast cancer cells and harbored miR-4443. +lncRNA target 30656681 hsa-mir-486 Colorectal Neoplasms Finally, CRC cells of the miR-NC pcDNA3.1-NRP-2 groups showed stronger proliferation, viability, and EMT than those of miR-NC and miR +transcription factor target 30656514 hsa-mir-210 Hypoxia-Ischemia, Brain Using both in vivo and in vitro models, herein we uncover a novel mechanism mediating oxidative brain injury after neonatal HI, in which miR-210 induces mitochondrial dysfunction via downregulation of iron-sulfur cluster assembly protein (ISCU). Therefore, miR-210 by downregulating ISCU and inducing mitochondrial dysfunction in neurons is a potent contributor of oxidative brain injury after neonatal HI. +other 30656427 hsa-mir-6872 gastric cardia adenocarcinoma 5p expression levels were associated with GCA patients' survival. +other 30655909 hsa-let-7d Ependymoma The expression of miRNAs were examined in 29 samples of ependymoma and we observed that miR-135a-3p, miR-137, miR5p, miR-181d and let-7d-5p were upregulated. +other 30655909 hsa-mir-137 Ependymoma The expression of miRNAs were examined in 29 samples of ependymoma and we observed that miR-135a-3p, miR-137, miR5p, miR-181d and let-7d-5p were upregulated. +other 30655909 hsa-mir-203a Ependymoma In addition, a significantly higher expression of miR-203a was detected in Grade III tumors suggesting its possible use as a prognostic or diagnostic marker. +other 30655909 hsa-mir-181d Ependymoma The expression of miRNAs were examined in 29 samples of ependymoma and we observed that miR-135a-3p, miR-137, miR5p, miR-181d and let-7d-5p were upregulated. +other 30655909 hsa-mir-135a Ependymoma The expression of miRNAs were examined in 29 samples of ependymoma and we observed that miR-135a-3p, miR-137, miR5p, miR-181d and let-7d-5p were upregulated. +other 30655909 hsa-mir-17 Ependymoma The expression of miRNAs were examined in 29 samples of ependymoma and we observed that miR-135a-3p, miR-137, miR5p, miR-181d and let-7d-5p were upregulated. +lncRNA target 30655907 hsa-mir-142 Osteosarcoma 5p suppressed proliferation and promoted apoptosis in human OS HOS cells by targeting PLA2G16 through ERK1/2 signaling pathway. +genetics_overexpression_promote 30655902 hsa-mir-106a Prostatic Neoplasms miR-106a was significantly upregulated in human prostate cancer tissues when compared with normal tissues (P<0.05), and the overexpression of miR-106a was identified to promote PC-3 cell growth. +transcription factor target 30655883 hsa-mir-153 Glioma Thus, miR-153/SNAI1 axis may be a novel target for cervical cancer treatment. +other 30655880 hsa-mir-141 Nasopharyngeal Carcinoma MicroRNA-183 and microRNA-141 may play an important role in the distant metastasis of NPC, and have a great impact on prognosis. +other 30655880 hsa-mir-183 Nasopharyngeal Carcinoma MicroRNA-183 and microRNA-141 may play an important role in the distant metastasis of NPC, and have a great impact on prognosis. +other 30655879 hsa-mir-345 Liver Neoplasms The aim of the study was to investigate the effects of miRNA-101 and miRNA-345 on HBV replication and liver cancer cell growth. miR-345 also upregulated the level of HBV replication, and promoted the proliferation of liver cancer cells. +other 30655868 hsa-mir-125b Melanoma The expression levels of seven of the miRNAs, miR-16, miR-21, miR-29b, miR-122, miR-125b, miR-204 and miR-383 were significantly upregulated; however, the expression of miR-205 was downregulated in CMM tissues compared with normal oral tissues. +other 30655868 hsa-mir-205 Melanoma The expression levels of seven of the miRNAs, miR-16, miR-21, miR-29b, miR-122, miR-125b, miR-204 and miR-383 were significantly upregulated; however, the expression of miR-205 was downregulated in CMM tissues compared with normal oral tissues. +other 30655868 hsa-mir-383 Melanoma It was concluded that miR-383 and miR-204 were potential oncomiRs that may be involved in regulating melanoma development by evading DNA repair and apoptosis. +other 30655868 hsa-mir-16 Melanoma The expression levels of seven of the miRNAs, miR-16, miR-21, miR-29b, miR-122, miR-125b, miR-204 and miR-383 were significantly upregulated; however, the expression of miR-205 was downregulated in CMM tissues compared with normal oral tissues. +other 30655868 hsa-mir-21 Melanoma The expression levels of seven of the miRNAs, miR-16, miR-21, miR-29b, miR-122, miR-125b, miR-204 and miR-383 were significantly upregulated; however, the expression of miR-205 was downregulated in CMM tissues compared with normal oral tissues. +other 30655868 hsa-mir-29b Melanoma The expression levels of seven of the miRNAs, miR-16, miR-21, miR-29b, miR-122, miR-125b, miR-204 and miR-383 were significantly upregulated; however, the expression of miR-205 was downregulated in CMM tissues compared with normal oral tissues. +other 30655868 hsa-mir-204 Melanoma It was concluded that miR-383 and miR-204 were potential oncomiRs that may be involved in regulating melanoma development by evading DNA repair and apoptosis. +other 30655868 hsa-mir-122 Melanoma The expression levels of seven of the miRNAs, miR-16, miR-21, miR-29b, miR-122, miR-125b, miR-204 and miR-383 were significantly upregulated; however, the expression of miR-205 was downregulated in CMM tissues compared with normal oral tissues. +tissue_expression_ns 30655858 hsa-mir-1207 Triple Negative Breast Neoplasms The present study first evaluated the expression levels of microRNA (miR)5p in human normal breast epithelial MCF-10A cells and TNBC cell lines (MDA-MB-231, MDA-MB-436 and MDA-MB-453). The results revealed that the highest miR5p level was in MDA-MB-231, which suggested an oncogenic role of miR5p in TNBC. Finally, miR5p expression was significantly increased, while LZTS1 expression was significantly decreased, in TNBC tissues when compared with normal adjacent tissues, and there was a negative correlation between miR5p and LZTS1 expression. In addition, there was a notable elevation in the expression of miR5p and a reduction in the expression of LZTS1 in the Taxol non-responsive TNBC tissues when compared with the Taxol-responsive TNBC tissues. The results of the present study suggested that miR5p may be a promising predictor of sensitivity towards Taxol in TNBC. +transcription factor target 30655844 hsa-mir-128a Glioma mir-128a may play a role similar to anti-oncogene in glioma, inhibiting the ability of proliferation, invasion and migration of glioma cells, and promoting the apoptosis of glioma cells. +genetics_overexpression_promote 30655843 hsa-mir-29 Osteosarcoma Overexpression of PTEN inhibited OS cell proliferation and migration and it could attenuate miR-29 promotion effect on OS progression. +genetics_overexpression_promote 30655837 hsa-mir-205 Pancreatic Carcinoma Notably, overexpression of RUNX2 partially reversed the inhibitory effect of miR-205 on PC cell proliferation and migration in vitro. +genetics_knock down_promote 30655833 hsa-mir-410 Colorectal Neoplasms In addition, knockdown of miR-410 promoted the expression of DKK, inhibited CRC cell proliferation, migration and invasion capacity, and induced cell apoptosis, while overexpression of miR-410 reversed these results. +genetics_overexpression_promote 30655830 hsa-mir-525 Chondrosarcoma Furthermore, miR-525 overexpression significantly suppressed the activation of focal adhesion kinase (FAK)/Src/phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (Akt) signaling in CHS cells; this suppression led to SPON1 silencing. +genetics_overexpression_promote 30655820 hsa-mir-34a Esophageal Squamous Cell Carcinoma Overexpression of miR-34a decreased FOXM1 mRNA and protein expression in the ESCC cell lines tested (TE-1 and TE-8). +genetics_overexpression_promote 30655818 hsa-mir-342 Squamous Cell Carcinoma of Head and Neck Further experiments suggested that overexpression of LASP1 attenuated the suppressive effect of miR +transcription factor target 30655816 hsa-mir-34a Breast Neoplasms Therefore, the results of the present study demonstrated that rhamnetin induced apoptosis in human breast cancer cells via the miR-34a/Notch-1 signaling pathway. +lncRNA target 30655812 hsa-mir-153 Nasopharyngeal Neoplasms The results of the present study indicate that miR-153 affects the progression of NPC by targeting the TGF-beta(2)/Smad2 signaling pathway. +genetics_knock down_promote 30655803 hsa-mir-218 Osteosarcoma Additionally, overexpression of miR-218 inhibited osteosarcoma cell proliferation, with the opposite result occurring following the knockdown of miR-218. +genetics_knock down_suppress 30655800 hsa-mir-183 Melanoma To assess the influence of microRNA-183 (miR-183) on the migration and invasion of A375 human melanoma cells, an A375 cell line with stable miR-183 overexpression or knockdown was constructed using lentiviral transfection. Additionally, miR-183 downregulation may be associated with the progression of melanoma. +other 30655799 hsa-mir-222 Ovarian Neoplasms 5p might be novel biomarkers for evaluating the prognosis of patients with EOC and that these two miRNAs might have potential therapeutic values. +other 30655799 hsa-mir-149 Ovarian Neoplasms 5p might be novel biomarkers for evaluating the prognosis of patients with EOC and that these two miRNAs might have potential therapeutic values. +genetics_overexpression_promote 30655782 hsa-mir-19a Osteosarcoma Taken together, overexpression of miR-19a-3p was observed in OS cell lines and that downregulation of miR-19a-3p enhanced the chemosensitivity of OS cells to Cisplatin, by elevating the expression of the tumor suppressor, PTEN. +circulation_biomarker_diagnosis_up 30655780 hsa-mir-214 Bone Neoplasms In summary, serum miR-214 expression may serve as a potential novel non-invasive biomarker for PCa screening through targeting PTEN. +circulation_biomarker_diagnosis_up 30655780 hsa-mir-214 Prostatic Neoplasms In summary, serum miR-214 expression may serve as a potential novel non-invasive biomarker for PCa screening through targeting PTEN. +genetics_overexpression_promote 30655777 hsa-mir-149 Thyroid cancer, medullary GIT1 overexpression partially reversed the inhibitory action of miR +transcription factor target 30655776 hsa-mir-24 Hodgkin Disease 3p could accelerate HL development through inhibiting DEDD. +genetics_knock down_suppress 30655773 hsa-mir-152 Carcinoma, Ovarian Epithelial After tumorigenesis, miR-124 mimics, miR-152 mimics, and their negative controls were transiently transfected into human OC SKOV3 cells via lipofection method. +genetics_knock down_suppress 30655773 hsa-mir-124 Carcinoma, Ovarian Epithelial After tumorigenesis, miR-124 mimics, miR-152 mimics, and their negative controls were transiently transfected into human OC SKOV3 cells via lipofection method. +lncRNA target 30655760 hsa-mir-21 Carcinoma, Hepatocellular Potential target genes of miR +other 30655742 hsa-mir-125a Nasopharyngeal Carcinoma As a small subpopulation of nasopharyngeal carcinoma (NPC), cancer stem-like cells (CSCs) function critically in multi-malignant behaviors, including tumorigenesis and metastasis; however, the expression pattern and regulatory role of miR-125a, miR-125b and p53 in CSCs derived from NPC remain unclear. +other 30655742 hsa-mir-125 Nasopharyngeal Carcinoma As a small subpopulation of nasopharyngeal carcinoma (NPC), cancer stem-like cells (CSCs) function critically in multi-malignant behaviors, including tumorigenesis and metastasis; however, the expression pattern and regulatory role of miR-125a, miR-125b and p53 in CSCs derived from NPC remain unclear. +other 30655742 hsa-mir-125b Nasopharyngeal Carcinoma As a small subpopulation of nasopharyngeal carcinoma (NPC), cancer stem-like cells (CSCs) function critically in multi-malignant behaviors, including tumorigenesis and metastasis; however, the expression pattern and regulatory role of miR-125a, miR-125b and p53 in CSCs derived from NPC remain unclear. +transcription factor target 30655740 hsa-mir-506 Urinary Bladder Neoplasms In summary, miR-506 may suppress the aggressive properties of human BCa cells by targeting RWDD4, and thus may be a novel therapeutic target in human BCa. +lncRNA target 30655737 hsa-mir-214 Colorectal Neoplasms MicroRNA 214 inhibits adipocyte enhancer-binding protein 1 activity and increases the sensitivity of chemotherapy in colorectal cancer. Therefore, AEBP1 may become a novel treatment for CRC patients with chemoresistance and may act through the upstream miR-214 to participate in the progression of a tumor. +genetics_knock down_suppress 30655679 hsa-mir-140 Carcinoma, Hepatocellular CONCLUSION: Collectively, our findings demonstrated that knockdown of SNHG16 attenuated sorafenib resistance in HCC through sponging miR +genetics_GWAS 30655677 hsa-mir-211 Colonic Neoplasms And SNP in rs187960998 of miR-211 was associated with tumor size, metastasis and tumor differentiation in CC patients. +lncRNA target 30654976 hsa-mir-24 Urinary Bladder Neoplasms HG) and their target genes (RCAN1 mRNA and FOSB mRNA) was examined by qPCR in bladder tissues and urine samples obtained from 196 individuals (98 patients with bladder cancer, 48 patients with benign lesions, and 50 healthy controls). +lncRNA target 30654976 hsa-mir-497 Urinary Bladder Neoplasms HG) and their target genes (RCAN1 mRNA and FOSB mRNA) was examined by qPCR in bladder tissues and urine samples obtained from 196 individuals (98 patients with bladder cancer, 48 patients with benign lesions, and 50 healthy controls). +lncRNA target 30654976 hsa-mir-4738 Urinary Bladder Neoplasms HG) and their target genes (RCAN1 mRNA and FOSB mRNA) was examined by qPCR in bladder tissues and urine samples obtained from 196 individuals (98 patients with bladder cancer, 48 patients with benign lesions, and 50 healthy controls). +transcription factor target 30654940 hsa-mir-27a Vascular Diseases In conclusion, these results indicate that miR-27a acts as a novel regulator of Ang II-induced proliferation and migration by directly targeting alpha-SMA expression in VSMCs in vitro, and may be a potential therapeutic target for treating vascular diseases. +other 30654931 hsa-mir-486 Diabetic Retinopathy The present study focuses on the MicroRNA-486/PTEN/FoxO1 pathway with the goal of identifying its physiological role in skeletal muscle atrophy induced by CHH as well as its role during NMES treatment. +other 30654931 hsa-mir-486 Muscular Atrophy The present study focuses on the MicroRNA-486/PTEN/FoxO1 pathway with the goal of identifying its physiological role in skeletal muscle atrophy induced by CHH as well as its role during NMES treatment. +lncRNA target 30654687 hsa-mir-93 Glioblastoma Abbreviations: ACTB: actin beta; ATG4B: autophagy related 4B cysteine peptidase; ATG5: autophagy related 5; BECN1: beclin 1; CL: classical; CQ: chloroquine diphosphate; CSCs: cancer stem cells; GBM: glioblastoma; GSCs: glioma stem-like cells; HEK: human embryonic kidney; IB: immunoblotting; IF: immunofluorescent staining; IR: irradiation; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MES: mesenchymal; MIR93: microRNA 93; MIRC: a control miRNA; miRNA/miR: microRNA; MTOR: mechanistic target of rapamycin kinase; NSC: NSC185085; PN: proneural; qRT-PCR: quantitative reverse transcription-polymerase chain reaction; Rap: rapamycin; SQSTM1/p62: sequestosome 1; TCGA: the cancer genome atlas; TMZ: temozolomide; WT: wild type; ZIP93: lentiviral miRZIP targeting MIR93; ZIPC: lentiviral miRZip targeting control miRNA. +lncRNA target 30654657 hsa-mir-221 Asthma AIM OF THE STUDY: To investigate the role of microRNA-221 (miR-221) in the airway epithelial cell injury in asthma and delineate the underlying mechanism that may involve with SIRT1. CONCLUSION: miR-221 may participate in the airway epithelial cells injury in asthma via targeting SIRT1. +genetics_overexpression_suppress 30654310 hsa-mir-146a Colitis In this study, extracellular vesicles (EVs) from cultured medium of bone-marrow mesenchymal stem cells (BMSCs) transfected with recombinant lentiviruses can serve as a stable delivery system and overexpress miR-146a, which significantly inhibited TNF receptor-associated factor 6 (TRAF6) and IL-1 receptor-associated kinase 1 (IRAK1) expression in TNBS-induced colitis of rats. Collectively, these data elucidated that EVs containing miR-146a ameliorates experimental colitis caused 2,4,6trinitrobenzenesulfonic acid (TNBS) by targeting TRAF6 and IRAK1. +transcription factor target 30654191 hsa-mir-873 Pancreatic Carcinoma In conclusion, we provide the first evidence that miR-873 acts as a tumor suppressor by targeting KRAS and that miR +transcription factor target 30654191 hsa-mir-873 Triple Negative Breast Neoplasms In conclusion, we provide the first evidence that miR-873 acts as a tumor suppressor by targeting KRAS and that miR +transcription factor target 30654114 hsa-mir-497 Ischemic Stroke Our data suggest that inhibition of miR-497 could protect cerebral ischemic injury by enhancing autophagy and also age-dependent. +circulation_biomarker_prognosis_ns 30653948 hsa-mir-107 Carcinoma, Hepatocellular CONCLUSION: Circulating miR-133b, miR-26a, miR-107 and miR-106 in serum are potential candidates to be utilized as prognostic biomarkers for predication of TACE treatment outcomes in HCC patients. +circulation_biomarker_prognosis_ns 30653948 hsa-mir-106 Carcinoma, Hepatocellular CONCLUSION: Circulating miR-133b, miR-26a, miR-107 and miR-106 in serum are potential candidates to be utilized as prognostic biomarkers for predication of TACE treatment outcomes in HCC patients. +circulation_biomarker_prognosis_ns 30653948 hsa-mir-133b Carcinoma, Hepatocellular CONCLUSION: Circulating miR-133b, miR-26a, miR-107 and miR-106 in serum are potential candidates to be utilized as prognostic biomarkers for predication of TACE treatment outcomes in HCC patients. +circulation_biomarker_prognosis_ns 30653948 hsa-mir-26a Carcinoma, Hepatocellular CONCLUSION: Circulating miR-133b, miR-26a, miR-107 and miR-106 in serum are potential candidates to be utilized as prognostic biomarkers for predication of TACE treatment outcomes in HCC patients. +other 30653707 hsa-mir-363 Vitamin A Deficiency In this study, we showed that the whole-embryo expression of miR-363 was upregulated in VAD rats. +circulation_biomarker_diagnosis_ns 30653586 hsa-mir-155 Cholangiocarcinoma RESULTS Serum concentrations of miR-122, miR-192, miR-29b and miR-155 were significantly elevated in patients with CCA compared to healthy controls or patients with primary sclerosing cholangitis without malignant transformation. +circulation_biomarker_diagnosis_ns 30653586 hsa-mir-192 Cholangiocarcinoma RESULTS Serum concentrations of miR-122, miR-192, miR-29b and miR-155 were significantly elevated in patients with CCA compared to healthy controls or patients with primary sclerosing cholangitis without malignant transformation. +circulation_biomarker_diagnosis_ns 30653586 hsa-mir-122 Cholangiocarcinoma RESULTS Serum concentrations of miR-122, miR-192, miR-29b and miR-155 were significantly elevated in patients with CCA compared to healthy controls or patients with primary sclerosing cholangitis without malignant transformation. +circulation_biomarker_diagnosis_ns 30653586 hsa-mir-29 Cholangiocarcinoma RESULTS Serum concentrations of miR-122, miR-192, miR-29b and miR-155 were significantly elevated in patients with CCA compared to healthy controls or patients with primary sclerosing cholangitis without malignant transformation. +circulation_biomarker_diagnosis_ns 30653586 hsa-mir-29b Cholangiocarcinoma RESULTS Serum concentrations of miR-122, miR-192, miR-29b and miR-155 were significantly elevated in patients with CCA compared to healthy controls or patients with primary sclerosing cholangitis without malignant transformation. +lncRNA target 30653462 hsa-mir-335 Brain Injuries, Traumatic 1 promoted neuroprotective effects by inhibiting neuronal apoptosis via the GAS5/miR-335/Rasa1 axis in TBI. +other 30652963 hsa-mir-122 Hepatitis C Hepatitis C virus (HCV) recruits two molecules of the liver-specific microRNA-122 (miR-122) to two adjacent sites (S1 and S2) located at the 5' end of the viral RNA genome. +lncRNA target 30652956 hsa-mir-296 Peritoneal Fibrosis Long noncoding RNA AK089579 inhibits epithelial-to-mesenchymal transition of peritoneal mesothelial cells by competitively binding to microRNA3p via DOK2 in peritoneal fibrosis. +other 30652678 hsa-mir-17 Sjogren's Syndrome CONCLUSIONS: Our data show that salivary mi146a may represent a marker of the disease, and that the expression of salivary miR17, 18a and 146b may be altered in patients with pSS, and associated with worse ultrasound and ESSPRI scores and anti-La/SSB positivity. +circulation_biomarker_diagnosis_ns 30652656 hsa-mir-21 Carcinoma, Non-Small-Cell Lung The plasma miRNA-21 and miRNA-23a levels in the lung cancer patients with distant metastasis (n = 20) were significantly higher than those in the patients without metastasis (n = 25) (P<0.0001 each), the expression of miR-21 and miRNA-23a was significantly associated with tumor size (P = 0.001, P = 0.0001, respectively), but not significantly related to lymph node metastasis (P = 0.687 and 0.696, respectively). A positive correlation was observed between miRNA-21 and miRNA-23a (r = 0.784, P<0.01), There was no significant difference in the plasma miRNA-21 and miRNA-23a levels in the lung cancer patients with different histopathological types. +other 30652656 hsa-mir-23a Carcinoma, Non-Small-Cell Lung Switching off miRNA-21 and miRNA-23a may improve the treatment of LC. +circulation_biomarker_diagnosis_ns 30652495 hsa-mir-29b Airway Inflammation Our findings indicate that miR-29b may participate in the airway inflammation in COPD by regulating inflammatory cytokine expression through targeting BRD4, plasma miR-29b may serve as a biomarker for disease severity in COPD, and oxidative stress may contribute to the decrease of miR-29b induced by cigarette smoke. +circulation_biomarker_diagnosis_ns 30652495 hsa-mir-29b Pulmonary Disease, Chronic Obstructive Our findings indicate that miR-29b may participate in the airway inflammation in COPD by regulating inflammatory cytokine expression through targeting BRD4, plasma miR-29b may serve as a biomarker for disease severity in COPD, and oxidative stress may contribute to the decrease of miR-29b induced by cigarette smoke. +genetics_knock down_promote 30652355 hsa-mir-28 Colonic Neoplasms 5p and that HOXB3 overexpression could mediate the functions of UCA1 in cell proliferation and migration of colon cancer cells. +lncRNA target 30652346 hsa-mir-223 Osteosarcoma Taken together, these experimental findings reveal that CC exhibits potential pharmacological activities against OS through inducing apoptosis and inhibiting miR +genetics_overexpression_promote 30652343 hsa-mir-145 Esophageal Squamous Cell Carcinoma In addition, overexpression of miR-145 suppressed cell proliferation and migration in ESCC cells. +lncRNA target 30652310 hsa-mir-525 Cardiomegaly In conclusion, SP1-induced upregulation of lncRNA SYNE1-AS1 promoted CH via miR5p/SP1 axis. +genetics_knock down_promote 30652073 hsa-mir-194 Nasopharyngeal Carcinoma We found that miR-194 binds the 3' untranslated region of MAP3K3, and knockdown of miR-194 inhibited nasopharyngeal carcinoma cell proliferation, migration and invasion. +genetics_GWAS 30651924 hsa-mir-34a Triple Negative Breast Neoplasms METHODS: 114 samples of DNA from paraffin embedded breast normal tissues of patients with triple negative breast cancer and 124 samples of healthy controls were collected and analyzed for pre-miR34a rs72631823 polymorphism. +other 30651891 hsa-mir-501 Pediatric Obesity 3p resulted downregulated). +other 30651891 hsa-mir-10b Pediatric Obesity 3p resulted downregulated). +other 30651891 hsa-mir-215 Pediatric Obesity 3p resulted downregulated). +other 30651891 hsa-mir-551a Pediatric Obesity 3p resulted downregulated). +other 30651891 hsa-mir-191 Pediatric Obesity 3p resulted downregulated). +other 30651891 hsa-mir-874 Pediatric Obesity 3p resulted downregulated). +genetics_overexpression_promote 30651878 hsa-mir-2861 Thyroid Cancer, Papillary In addition, rescue experiments indicated that ectopic expression of miR-2861 reversed the effects of DGCR5 overexpression on PTC cell proliferation and invasion. +genetics_overexpression_suppress 30651872 hsa-mir-1224 Melanoma 5p, and its overexpression is associated with poor survival of melanoma patients. +lncRNA target 30651865 hsa-mir-93 Peripheral Arterial Disease These results demonstrate that curcumin had beneficial effects in non-diabetic PAD by improving angiogenesis, which may have been achieved partially via the promotion of miR-93 expression. +lncRNA target 30651857 hsa-mir-137 Osteosarcoma In summary, the present study suggests that XIST promotes OS cell proliferation and invasion by inhibition of miR-137 expression. +circulation_biomarker_diagnosis_ns 30651854 hsa-mir-21 Osteoporosis MicroRNA-21 is expressed at low level in bone tissue and serum in patients with OP, and microRNA-21 can promote osteogenic differentiation of BMSCs. +genetics_overexpression_promote 30651845 hsa-mir-148a Pancreatic Carcinoma Most importantly, ectopic overexpression of miR-148a in pancreatic cancer cells inhibited tumor formation in an animal experiment. +lncRNA target 30651809 hsa-mir-138 Stomatitis, Herpetic Therefore, the expression of miR-138 may be used as a potential therapeutic target for HSV. +lncRNA target 30651793 hsa-mir-122 Hepatitis As micro RNA (miRNA)-122 is known to be associated with liver inflammation, its effects on the epithelial-mesenchymal transition (EMT) of HSCs through the inhibition of the TGF-beta1/drosophila mothers against decapentaplegic protein 4 (Smad4) signaling pathway were investigated. +genetics_overexpression_promote 30651786 hsa-mir-200a Glioma Furthermore, FOXA1 expression was negatively mediated by miR-200a in glioma cells and the overexpression of FOXA1 eliminated the inhibitory effects of miR-200a on the survival, proliferation and invasion of glioma cells. +other 30651779 hsa-mir-101 Osteoarthritis Collectively, our research revealed promotion function of miR-101 on chondrogenic differentiation of MSCs, indicating that miR-101 could be a potential therapeutic strategy for the treatment of osteoarthritis (OA). +circulation_biomarker_diagnosis_ns 30651771 hsa-mir-370 Atherosclerosis In the present study, the expression levels of miR-370 in peripheral blood mononuclear cells of patients with coronary atherosclerosis were significantly increased compared with healthy patients, as demonstrated by reverse transcription-quantitative polymerase chain reaction analysis. +tissue_expression_ns 30651631 hsa-mir-145 Chromosome 5q Deletion Syndrome Combined Rps14/Csnk1a1/miR-145/146a deficiency recapitulated the cardinal features of the 5q- syndrome, including (1) more severe anemia with faster kinetics than Rps14 haploinsufficiency alone and (2) pathognomonic megakaryocyte morphology. +genetics_GWAS 30651325 hsa-mir-1224 Chronic Pain Here, we found that the increase of circRNA-Filip1l mediated by miRNA-1224 in an Ago2-dependent way in the spinal cord is involved in regulation of nociception via targeting Ubr5 Our study reveals a novel epigenetic mechanism of interaction between miRNA and circRNA in chronic inflammation pain. +epigenetics 30651148 hsa-mir-199a-2 Melanoma In addition, analysis of data from melanoma patients showed a stage- and tissue type-dependent modulation of MIR-199A2 expression by DNA methylation. +circulation_biomarker_diagnosis_ns 30650411 hsa-mir-195 Breast Neoplasms 3p expressions were deregulated in serum samples of obese and nonobese postmenopausal women with BC. +circulation_biomarker_diagnosis_ns 30650411 hsa-mir-221 Breast Neoplasms 3p expressions were deregulated in serum samples of obese and nonobese postmenopausal women with BC. +circulation_biomarker_diagnosis_ns 30650411 hsa-mir-17 Breast Neoplasms 3p expressions were deregulated in serum samples of obese and nonobese postmenopausal women with BC. +circulation_biomarker_diagnosis_up 30650288 hsa-mir-146 Osteoarthritis Objective To observe the relationship between blood stasis state and activation of nuclear factor--gene binding (NF-B) signaling pathway/miRNA-146 in osteoarthritis (OA) patients and the effect of Xinfeng Capsule (XFC) on them. Conclusion XFC could regulate the immunity and restore the equilibrium of cytokine network, and protect vascular endothelial cells possibly by up-regulating miRNA-146 expression and inhibiting acti- vation of NF-B signaling pathway, thus improving blood stasis state of OA. +transcription factor target 30650225 hsa-mir-193b Influenza, Human Collectively, our findings suggest that miR-193b represses IAV infection by inhibiting Wnt/-catenin signalling. +lncRNA target 30649914 hsa-mir-22 Reperfusion Injury By inhibition of Smurf2 translation, miR-322/503 induces EZH2 expression and activates Akt/GSK3beta pathway, thereby protecting cells from ischemia reperfusion injury. +circulation_biomarker_diagnosis_up 30649809 hsa-mir-24 Cerebral Infarction CONCLUSION miR-24 reduced serum TCH, HDL and TG levels and inhibited brain tissue cell apoptosis in rats with cerebral infarction. +other 30649630 hsa-mir-122 Carcinoma, Hepatocellular A mercapto-modified probe DNA that is complementary to the hepatocellular carcinoma biomarker microRNA-122 was firstly anchored on a gold electrode (AuE). +genetics_overexpression_suppress 30648758 hsa-mir-3150a Arthritis, Rheumatoid Our results indicate that melatonin ameliorates RA by inhibiting TNF-alpha and IL-1beta production through downregulation of the PI3K/AKT, ERK, NF-kappaB signaling pathways, as well as miR-3150a-3p overexpression. +lncRNA target 30648255 hsa-mir-139 Fibrosis As microRNA (miR)-139 could target several factors in Wnt signaling to modulate fibrosis, here, the effect and mechanism of miR-139 in HTF activation and proliferation were investigated. +genetics_overexpression_promote 30648255 hsa-mir-139 Hashimoto Disease miR-139 overexpression significantly reversed the TGFbeta1-induced increase in collagen I and alpha-smooth muscle actin contents and proliferation in HTFs. +genetics_overexpression_promote 30648022 hsa-mir-705 Osteoporosis miR-705 was found overexpressed in OVX mandibular MSCs. The knock down of miR-705 in vitro partially attenuated the differentiation disorder of the OVX mandibular MSCs by upregulating the expression of osteogenic marker genes but suppressing adipogenic genes. +lncRNA target 30646925 hsa-mir-214 Stomach Neoplasms CONCLUSIONS This study showed that miR-214 inhibited the tumor-promoting effect of CAFs on GC through targeting FGF9 in CAFs and regulating the EMT process in GC cells, suggesting miRNA-214/FGF9 in CAFs as a potential target for therapeutic approaches in GC. +other 30646895 hsa-mir-19b Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 5p-CDC25A and MYB/SOX4-miR-19b-3p-RBBP8 were identified as important feed-forward loops involved in the oncogenesis of T-ALL. +circulation_biomarker_diagnosis_ns 30646802 hsa-mir-125 Vascular Calcification Background Micro RNA -125b (miR-125b) has been shown to regulate vascular calcification ( VC ), and serum miR-125b levels are a potential biomarker for estimating the risk of uremic VC status. Adding serum miR-125b levels and serum osteoprotegerin levels (>/=400 pg/mL) into models estimating the risk of uremic VC increased the area under receiver operating characteristic curve values (for models without miR-125b/osteoprotegerin, with miR-125b, and both: 0.74, 0.79, and 0.81, respectively). +circulation_biomarker_diagnosis_ns 30646802 hsa-mir-125b Vascular Calcification Conclusions Serum osteoprotegerin levels >/=400 pg/mL and serum miR-125b levels synergistically increased the accuracy of estimating VC risk among patients receiving chronic dialysis. +other 30645846 hsa-mir-21 Lung Neoplasms 3p were statistically different (P <0. +other 30645846 hsa-mir-141 Lung Neoplasms 3p were statistically different (P <0. +other 30645846 hsa-mir-10a Lung Neoplasms 3p were statistically different (P <0. +other 30645846 hsa-mir-21 Carcinoma, Non-Small-Cell Lung 5p are promising to become molecular markers for efficacy monitoring and prediction of advanced NSCLC treated by TCM combined WM, which provides reference for individualized treating advanced NSCLC. +other 30645846 hsa-mir-182 Carcinoma, Non-Small-Cell Lung 5p are promising to become molecular markers for efficacy monitoring and prediction of advanced NSCLC treated by TCM combined WM, which provides reference for individualized treating advanced NSCLC. +other 30645846 hsa-mir-182 Lung Neoplasms 3p were statistically different (P <0. +other 30645846 hsa-mir-342 Lung Neoplasms 3p were statistically different (P <0. +transcription factor target 30645141 hsa-mir-134 Fibrosis Herein we investigate the role and mechanisms of miR-134 in hepatic fibrosis. Collectively, these data suggest that miR-134 inhibits the activation of HSCs via directly targeting TAB1, and the restoration of miR-134 or targeting TAB1 is of clinical significance in the treatment of liver fibrosis. +genetics_knock down_promote 30644438 hsa-mir-15a Pulmonary Fibrosis Moreover, knockdown of miR-15a resulted in fibroblast activation and lung fibrosis through promoting Twist expression by targeting inhibition of YAP1. +lncRNA target 30644396 hsa-mir-29b Pancreatic Carcinoma Among these, miRNA-29a/b targeted genes were found to be most significantly altered in comparative profiling of HC, CP and PDAC, indicating its involvement in malignant evolution. +lncRNA target 30644396 hsa-mir-29a Pancreatic Carcinoma Among these, miRNA-29a/b targeted genes were found to be most significantly altered in comparative profiling of HC, CP and PDAC, indicating its involvement in malignant evolution. +lncRNA target 30644128 hsa-mir-135a Myocardial Reperfusion Injury Here we aim to elucidate the effects and mechanism of miR-135a, a previously reported regulator of ischemia-reperfusion (I/R) injury, in myocardial I/R injury. In summary, this study demonstrates that miR-135a exerts protective effects against myocardial I/R injury by targeting PTP1B. +other 30643918 hsa-mir-379 Diabetic Nephropathies These results indicate that, by elevating the secretion of IL-1beta, miR5p regulation of GSDMD is involved in arsenite-induced activation of HSCs and in hepatic fibrosis. +other 30643194 hsa-mir-96 Carcinoma, Hepatocellular In summary, a new oncofetal lncRNA Ptn-dt is identified, and it can promote the proliferation of HCC cells by regulating the HuR/miR-96/Alk pathway and Ptn-Alk axis. +transcription factor target 30643084 hsa-mir-21 Plaque, Atherosclerotic Furthermore, miR21 might be potential target to prevent atherosclerotic rupture. +circulation_biomarker_diagnosis_up 30643043 hsa-mir-21 Carcinoma, Non-Small-Cell Lung Especially, the expression of miR-21 in serum of NSCLC patients after obtaining resistance was up-regulated more than 10-fold compared with that before treatment. +transcription factor target 30643010 hsa-mir-146b Osteosarcoma Our findings identified p16INK4a and miR-146b-5p as tumor suppressors, and suggested p16INK4a, miR-146b-5p and TRAF6 as potential therapeutic candidates for malignant OS. +genetics_knock down_suppress 30643007 hsa-mir-141 Pancreatic Carcinoma The knockdown of TP73-AS1 significantly inhibited the migration and invasion of pancreatic cancer cells, while the miR-141 inhibitor significantly restored the migration and invasion. +lncRNA target 30642743 hsa-mir-20b Prostatic Neoplasms In summary, the silencing of MALAT1 inactivated AR signaling by sponging miR-320b, and inhibited proliferation and cell cycle progression in prostate cancer cells, suggesting that MALAT1 may be a new target in diagnosis and therapy of prostate cancer in clinic. +exosome 30642385 hsa-mir-196a Nevus, Halo Exosomal miR-196a then binds novel targets, CDKN1B and ING5, to endow HNC cells with cisplatin resistance. +circulation_biomarker_diagnosis_ns 30642348 hsa-mir-659 Obesity Circulating miR-3659 may be a potential biomarker of dyslipidemia in patients with obesity. +circulation_biomarker_diagnosis_ns 30642348 hsa-mir-659 Dyslipidemias Circulating miR-3659 may be a potential biomarker of dyslipidemia in patients with obesity. +genetics_GWAS 30642347 hsa-mir-146a Malaria A miRNA-146a rs2910164 G > C single nucleotide polymorphism (SNP) has been associated with increased risks of several diseases, but no data as to malaria are available. These findings suggest that miRNA-146a is involved in protective malarial immunity, and specifically in the innate component. +other 30642078 hsa-mir-146a Cerebrovascular Disorders In conclusion, the results support the existence of a role for miR-146a rs2910164 and miR-499 rs3746444 in determining susceptibility to CCDs, especially CAD. +other 30642078 hsa-mir-499 Cerebrovascular Disorders In conclusion, the results support the existence of a role for miR-146a rs2910164 and miR-499 rs3746444 in determining susceptibility to CCDs, especially CAD. +other 30642005 hsa-mir-29a Diabetic Nephropathies Collectively, our findings indicate that the interaction between miR-29a, CB1R, and PPAR-gamma may play an important role in protecting diabetic renal glomeruli from fibrotic injuries. +circulation_biomarker_diagnosis_ns 30640521 hsa-mir-199a Reperfusion Injury, Renal Ischemia BMSCs protect against renal ischemia-reperfusion injury by secreting exosomes loaded with miR-199a-5p that target BIP to inhibit endoplasmic reticulum stress at the very early reperfusion stages. +lncRNA target 30640176 hsa-mir-155 Inflammation Targeted inhibition of miR-23a and miR-155 in cultured intestinal epithelial cells and in acutely injured mucosa decreased the detrimental effects of PMNs and enhanced tissue healing responses, suggesting that this approach can be used in therapies aimed at resolution of inflammation, in wound healing, and potentially to prevent neoplasia. +lncRNA target 30640176 hsa-mir-23a Inflammation Targeted inhibition of miR-23a and miR-155 in cultured intestinal epithelial cells and in acutely injured mucosa decreased the detrimental effects of PMNs and enhanced tissue healing responses, suggesting that this approach can be used in therapies aimed at resolution of inflammation, in wound healing, and potentially to prevent neoplasia. +other 30639697 hsa-mir-363 Depression Our results support a therapeutic role for mir363-3p for long-term stroke disability. +other 30639603 hsa-mir-335 Precursor Cell Lymphoblastic Leukemia-Lymphoma 3p and ABCA3 mRNA expression profiles in cALL patients (r=0.5019, P=0.002). +genetics_knock down_promote 30639456 hsa-mir-142 Ovarian Neoplasms In contrast, introducing XIAP without a 3'UTR counteracted the effect of overexpressed miR +genetics_overexpression_promote 30639441 hsa-mir-532 Urinary Bladder Neoplasms Functional experiments showed that overexpression of miR +other 30639391 hsa-mir-9 Coronary Disease miR-9 was proposed to be upregulated in cardiac tissues from CHD cases. +genetics_knock down_suppress 30639311 hsa-mir-16 Mouth Neoplasms In addition, knockdown of miR-16 reversed the effect of quercetin on progression of oral cancer. +transcription factor target 30639269 hsa-mir-145 Pulmonary Disease, Chronic Obstructive 5p conferred protection against CSE-induced airway epithelial cell apoptosis and inflammation partially via targeting KLF5, which might be a potential therapeutic biomarker in COPD treatment. +lncRNA target 30639194 hsa-mir-30 Pancreatic Carcinoma 5p to inhibit PAX8 in a competitive fashion, thereby preventing the progression of PC. +lncRNA target 30639170 hsa-mir-145 Colorectal Neoplasms In summary, CASC15 silencing overcame OXA resistance of CRC by regulating miR-145/ABCC1 axis, providing a potential therapeutic target for CRC chemoresistance. +genetics_overexpression_promote 30639060 hsa-mir-21 Optic Nerve Injuries METHODS: Rats with ONC injury were transfected with miRNA-21 (miR-21) agomir (overexpressing miR-21) or antagomir (inhibiting miR-21) via intravitreous injection. +tissue_expression_ns 30639035 hsa-mir-675 Laminopathies Early H19 lncRNA deficiency blocked endothelial-to-hematopoietic transition, which was independent of the H19-derived miR, miR-675. +lncRNA target 30638952 hsa-mir-375 Esophageal Squamous Cell Carcinoma In conclusion, our findings suggest that miR-375 serves as a promising independent prognostic factor for ESCC and function as a tumor suppressor. +other 30638935 hsa-mir-342 Carcinoma, Pancreatic Ductal 3p during adipogenesis, this obesity-associated miRNA may operate as a novel posttranscriptional integrator linking lipid homeostasis and pancreatic chemoresistance. +transcription factor target 30638858 hsa-mir-19a Carcinoma, Hepatocellular Moreover, we also found that PFN1 was a direct target gene of miR-19a-3p, and in HCC tissues, and there was a significantly inverse correlation between PFN1 mRNA and miR-19a-3p expression. +lncRNA target 30638403 hsa-mir-454 Carcinoma, Non-Small-Cell Lung 3p suppressed NSCLC cell functions, which may shed light on its potential application in NSCLC therapy. +other 30638284 hsa-mir-27b Lichen Planus, Oral Decreased miR-27b may have induced cell proliferation by increasing the levels of PLK2 in HOKs, which provides a new perspective into the potential mechanisms underlying OLP development. +genetics_knock down_suppress 30638178 hsa-mir-152 Fibrosis 5p, and knockdown of Smad3 also inhibits fibrosis progression, consistent with the overexpression of miR +genetics_overexpression_suppress 30638178 hsa-mir-152 Keloid Overexpression of miR +genetics_overexpression_promote 30637864 hsa-mir-9 Multiple Myeloma miR-9 was upregulated in MM patients and cell lines, and miR-9 overexpression promoted proliferation and repressed apoptosis in MM cell lines. +genetics_knock down_promote 30637800 hsa-mir-137 Prostatic Neoplasms Collectively, the present study showed that miR-137 repressed glycolysis in prostate cancer through knockdown of NOX4, which might be a potential theoretical target for prostate cancer treatment. +circulation_biomarker_diagnosis_up 30637733 hsa-mir-424 Diabetic Nephropathies The upregulation of miR-424 improved renal lesion and DN symptoms of blood glucose level, urine protein level, body weight, creatinine level, blood urea nitrogen, and KW/BW ratio. +genetics_GWAS 30637557 hsa-mir-499 Venous Thromboembolism This case-control study sought to determine the correlation between the presence of polymorphisms in the genes encoding the miRNAs miR-146a, miR-149, miR-196a2, miR-499, and VTE in Korean patients. +genetics_GWAS 30637557 hsa-mir-196a-2 Venous Thromboembolism This case-control study sought to determine the correlation between the presence of polymorphisms in the genes encoding the miRNAs miR-146a, miR-149, miR-196a2, miR-499, and VTE in Korean patients. +genetics_GWAS 30637557 hsa-mir-149 Venous Thromboembolism This case-control study sought to determine the correlation between the presence of polymorphisms in the genes encoding the miRNAs miR-146a, miR-149, miR-196a2, miR-499, and VTE in Korean patients. +genetics_GWAS 30637557 hsa-mir-146a Venous Thromboembolism This case-control study sought to determine the correlation between the presence of polymorphisms in the genes encoding the miRNAs miR-146a, miR-149, miR-196a2, miR-499, and VTE in Korean patients. +lncRNA target 30636880 hsa-mir-26a Melanoma CONCLUSION: SNHG5 promoted melanoma development by inhibiting miR-26a-5p and facilitating TRPC3 expression, highlighting the potential of SNHG5 as a novel target therapy for melanoma. +lncRNA target 30636484 hsa-mir-206 Fetal Growth Retardation Thus, miR-206 may be a trigger for induction of exaggerated CH-pulmonary artery hypertension of IUGR via Kv1.5. +genetics_overexpression_promote 30636169 hsa-mir-542 Osteosarcoma 3p overexpression down-regulated its target gene ILK, promoted osteosarcoma cells apoptosis and inhibited their proliferation, migration and invasion. +genetics_knock down_suppress 30635938 hsa-mir-124 Tongue Neoplasms UCA1 knockdown ameliorated, whereas miR-124 inhibition exacerbated TGFbeta1-induced EMT and invasion in tongue cancer cells through miR-124 downstream jagged 1 (JAG1) and Notch signaling. +lncRNA target 30635407 hsa-mir-92a-1 Gastric Intestinal Metaplasia Suppression of miR-92a5p and restoration of FOXD1 may be a preventive approach for gastric IM in patients with bile regurgitation. +lncRNA target 30635217 hsa-mir-129 Stomach Neoplasms 5p associated with gastric cancer proliferation and EMT, and serves as a potential diagnostic and therapeutic target via miR +lncRNA target 30635008 hsa-mir-27b Arteriovenous Fistula 3p which were up-regulated in AV shunts, and miR-27b-3p, miR-10b-5p, let-7b-5p, and let-7c-5p, which were down-regulated in AV shunts, with their predicted interacting targets C-X-C chemokine receptor 2 (CXCR2), interleukin-1 alpha (IL1A), ephrin receptor kinase 2 (EPHA2), synaptojanin-2 binding protein (SYNJ2BP), forkhead box C1 (FOXC1) were present. +lncRNA target 30635008 hsa-mir-27b Congenital heart block 3p which were up-regulated in AV shunts, and miR-27b-3p, miR-10b-5p, let-7b-5p, and let-7c-5p, which were down-regulated in AV shunts, with their predicted interacting targets C-X-C chemokine receptor 2 (CXCR2), interleukin-1 alpha (IL1A), ephrin receptor kinase 2 (EPHA2), synaptojanin-2 binding protein (SYNJ2BP), forkhead box C1 (FOXC1) were present. +lncRNA target 30635008 hsa-let-7c Congenital heart block 3p which were up-regulated in AV shunts, and miR-27b-3p, miR-10b-5p, let-7b-5p, and let-7c-5p, which were down-regulated in AV shunts, with their predicted interacting targets C-X-C chemokine receptor 2 (CXCR2), interleukin-1 alpha (IL1A), ephrin receptor kinase 2 (EPHA2), synaptojanin-2 binding protein (SYNJ2BP), forkhead box C1 (FOXC1) were present. +lncRNA target 30635008 hsa-let-7c Arteriovenous Fistula 3p which were up-regulated in AV shunts, and miR-27b-3p, miR-10b-5p, let-7b-5p, and let-7c-5p, which were down-regulated in AV shunts, with their predicted interacting targets C-X-C chemokine receptor 2 (CXCR2), interleukin-1 alpha (IL1A), ephrin receptor kinase 2 (EPHA2), synaptojanin-2 binding protein (SYNJ2BP), forkhead box C1 (FOXC1) were present. +lncRNA target 30635008 hsa-mir-449a Congenital heart block 3p which were up-regulated in AV shunts, and miR-27b-3p, miR-10b-5p, let-7b-5p, and let-7c-5p, which were down-regulated in AV shunts, with their predicted interacting targets C-X-C chemokine receptor 2 (CXCR2), interleukin-1 alpha (IL1A), ephrin receptor kinase 2 (EPHA2), synaptojanin-2 binding protein (SYNJ2BP), forkhead box C1 (FOXC1) were present. +lncRNA target 30635008 hsa-mir-449a Arteriovenous Fistula 3p which were up-regulated in AV shunts, and miR-27b-3p, miR-10b-5p, let-7b-5p, and let-7c-5p, which were down-regulated in AV shunts, with their predicted interacting targets C-X-C chemokine receptor 2 (CXCR2), interleukin-1 alpha (IL1A), ephrin receptor kinase 2 (EPHA2), synaptojanin-2 binding protein (SYNJ2BP), forkhead box C1 (FOXC1) were present. +lncRNA target 30635008 hsa-mir-19b Arteriovenous Fistula 3p which were up-regulated in AV shunts, and miR-27b-3p, miR-10b-5p, let-7b-5p, and let-7c-5p, which were down-regulated in AV shunts, with their predicted interacting targets C-X-C chemokine receptor 2 (CXCR2), interleukin-1 alpha (IL1A), ephrin receptor kinase 2 (EPHA2), synaptojanin-2 binding protein (SYNJ2BP), forkhead box C1 (FOXC1) were present. +lncRNA target 30635008 hsa-mir-19b Congenital heart block 3p which were up-regulated in AV shunts, and miR-27b-3p, miR-10b-5p, let-7b-5p, and let-7c-5p, which were down-regulated in AV shunts, with their predicted interacting targets C-X-C chemokine receptor 2 (CXCR2), interleukin-1 alpha (IL1A), ephrin receptor kinase 2 (EPHA2), synaptojanin-2 binding protein (SYNJ2BP), forkhead box C1 (FOXC1) were present. +lncRNA target 30635008 hsa-mir-130b Arteriovenous Fistula 3p which were up-regulated in AV shunts, and miR-27b-3p, miR-10b-5p, let-7b-5p, and let-7c-5p, which were down-regulated in AV shunts, with their predicted interacting targets C-X-C chemokine receptor 2 (CXCR2), interleukin-1 alpha (IL1A), ephrin receptor kinase 2 (EPHA2), synaptojanin-2 binding protein (SYNJ2BP), forkhead box C1 (FOXC1) were present. +lncRNA target 30635008 hsa-mir-10b Arteriovenous Fistula 3p which were up-regulated in AV shunts, and miR-27b-3p, miR-10b-5p, let-7b-5p, and let-7c-5p, which were down-regulated in AV shunts, with their predicted interacting targets C-X-C chemokine receptor 2 (CXCR2), interleukin-1 alpha (IL1A), ephrin receptor kinase 2 (EPHA2), synaptojanin-2 binding protein (SYNJ2BP), forkhead box C1 (FOXC1) were present. +lncRNA target 30635008 hsa-mir-223 Arteriovenous Fistula 3p which were up-regulated in AV shunts, and miR-27b-3p, miR-10b-5p, let-7b-5p, and let-7c-5p, which were down-regulated in AV shunts, with their predicted interacting targets C-X-C chemokine receptor 2 (CXCR2), interleukin-1 alpha (IL1A), ephrin receptor kinase 2 (EPHA2), synaptojanin-2 binding protein (SYNJ2BP), forkhead box C1 (FOXC1) were present. +lncRNA target 30635008 hsa-mir-511 Congenital heart block 3p which were up-regulated in AV shunts, and miR-27b-3p, miR-10b-5p, let-7b-5p, and let-7c-5p, which were down-regulated in AV shunts, with their predicted interacting targets C-X-C chemokine receptor 2 (CXCR2), interleukin-1 alpha (IL1A), ephrin receptor kinase 2 (EPHA2), synaptojanin-2 binding protein (SYNJ2BP), forkhead box C1 (FOXC1) were present. +lncRNA target 30635008 hsa-mir-130b Congenital heart block 3p which were up-regulated in AV shunts, and miR-27b-3p, miR-10b-5p, let-7b-5p, and let-7c-5p, which were down-regulated in AV shunts, with their predicted interacting targets C-X-C chemokine receptor 2 (CXCR2), interleukin-1 alpha (IL1A), ephrin receptor kinase 2 (EPHA2), synaptojanin-2 binding protein (SYNJ2BP), forkhead box C1 (FOXC1) were present. +lncRNA target 30635008 hsa-mir-223 Congenital heart block 3p which were up-regulated in AV shunts, and miR-27b-3p, miR-10b-5p, let-7b-5p, and let-7c-5p, which were down-regulated in AV shunts, with their predicted interacting targets C-X-C chemokine receptor 2 (CXCR2), interleukin-1 alpha (IL1A), ephrin receptor kinase 2 (EPHA2), synaptojanin-2 binding protein (SYNJ2BP), forkhead box C1 (FOXC1) were present. +lncRNA target 30635008 hsa-mir-10b Congenital heart block 3p which were up-regulated in AV shunts, and miR-27b-3p, miR-10b-5p, let-7b-5p, and let-7c-5p, which were down-regulated in AV shunts, with their predicted interacting targets C-X-C chemokine receptor 2 (CXCR2), interleukin-1 alpha (IL1A), ephrin receptor kinase 2 (EPHA2), synaptojanin-2 binding protein (SYNJ2BP), forkhead box C1 (FOXC1) were present. +lncRNA target 30635008 hsa-mir-511 Arteriovenous Fistula 3p which were up-regulated in AV shunts, and miR-27b-3p, miR-10b-5p, let-7b-5p, and let-7c-5p, which were down-regulated in AV shunts, with their predicted interacting targets C-X-C chemokine receptor 2 (CXCR2), interleukin-1 alpha (IL1A), ephrin receptor kinase 2 (EPHA2), synaptojanin-2 binding protein (SYNJ2BP), forkhead box C1 (FOXC1) were present. +other 30634634 hsa-mir-340 Diabetes Mellitus, Type 2 Additionally, the potential miR3p-DTX3L interaction that has been systematically validated in miRNA prediction databases was proposed to participate in the disrupted skin homeostasis, altering the defense and immune response of diabetic skin. +other 30634628 hsa-mir-134 Melanoma Levels of miR5p and miR-320a-3p were significantly down-regulated (p < 0.001) in melanoma samples (n = 96) compared to healthy controls (n = 28). +other 30634628 hsa-mir-20a Melanoma Levels of miR5p and miR-320a-3p were significantly down-regulated (p < 0.001) in melanoma samples (n = 96) compared to healthy controls (n = 28). +other 30633643 hsa-mir-146a Metabolic Diseases Our findings suggest that miR5p, as well as one or more genes at the Chromosome 12 QTL (possibly Numb or Dlst), is strongly linked to TMAO levels and likely involved in the control of atherosclerosis. +other 30633643 hsa-mir-146 Metabolic Diseases Our findings suggest that miR5p, as well as one or more genes at the Chromosome 12 QTL (possibly Numb or Dlst), is strongly linked to TMAO levels and likely involved in the control of atherosclerosis. +lncRNA target 30633364 hsa-mir-8075 Uterine Cervical Neoplasms Furthermore, we validated that upregulation of TPX2 by hsa_circRNA_101996-mediated inhibition of miR-8075 contributed to cervical cancer proliferation, migration, and invasion. +lncRNA target 30633360 hsa-mir-202 Uterine Cervical Neoplasms 3p axis, plays an important role in regulating cell viability, cell migration and invasion, and EMT of CC cells via activating Akt/mTOR signaling. +genetics_overexpression_promote 30633357 hsa-mir-210 Adenocarcinoma of Lung Then, it was shown that overexpression of miR-210 was able to promote lung cancer cell proliferation and colony formation ability while inhibitors of miR-210 exhibited a reversed phenomenon. +lncRNA target 30633243 hsa-mir-196a-2 Myocardial Infarction One of its four topological clusters contained the majority of miR-196a2 target genes associated with atherosclerosis, coronary artery disease or myocardial infarction and was enriched with the genes regulating the TGFbeta and class I MHC signaling pathways, platelet activation/aggregation, and the cell cycle control. +transcription factor target 30632265 hsa-mir-15a Thrombosis Targeting miR-15a-5p may have therapeutic potential in hemostasis and thrombosis. +lncRNA target 30632031 hsa-mir-29b Carcinoma, Hepatocellular Our previous reports demonstrated that oligo-fucoidan from the brown seaweed Sargassum hemiphyllum elevates microRNA-29b to inhibit epithelial-mesenchymal transition in hepatoma cells. +genetics_knock down_promote 30631060 hsa-mir-106a Colonic Neoplasms The aberrant upregulation of miR-20a/miR-106a were identified as the reason of WTX loss in CRC both in vivo and in vitro. These study defined the mechanism how miR-20a/miR-106a-mediated WTX loss regulates CRC progression and metastasis, and provided a potential therapeutic target for preventing CRC progression. +genetics_knock down_promote 30631060 hsa-mir-20a Colonic Neoplasms The aberrant upregulation of miR-20a/miR-106a were identified as the reason of WTX loss in CRC both in vivo and in vitro. These study defined the mechanism how miR-20a/miR-106a-mediated WTX loss regulates CRC progression and metastasis, and provided a potential therapeutic target for preventing CRC progression. +genetics_overexpression_promote 30631050 hsa-mir-1254 Stomach Neoplasms In summary, overexpression of miR-1254 could suppress proliferation, migration, invasion, and EMT via PI3K/AKT signaling pathways by downregulation of Smurf1 in GC, which suggests a potential therapeutic target for GC. +genetics_knock down_promote 30631046 hsa-mir-590 Breast Neoplasms Further, the noted loss of ERalpha-miR590-5p axis may upregulate the expression of FAM171A1 and consequently, resulting aggressiveness of TNBC cells. +other 30631040 hsa-mir-16 Chondrosarcoma We also found a positive correlation between resistin and VEGF-A expression, and a negative correlation between resistin and VEGF-A with miR5p in chondrosarcoma patients. +genetics_knock down_promote 30630646 hsa-mir-338 Colonic Neoplasms These findings revealed that knockdown of circ_0001313 could induce radio-sensitivity of colon cancer cells by negatively regulating miR +other 30629937 hsa-mir-181a Esophageal Squamous Cell Carcinoma We have found that an miR-181a(high) subpopulation of cells sorted from primary ovarian tumor cells exhibited TIC properties in vivo, were enriched in response to continuous cisplatin treatment, and showed activation of numerous major stem cell regulatory pathways. +other 30629937 hsa-mir-181a Ovarian Neoplasms We have found that an miR-181a(high) subpopulation of cells sorted from primary ovarian tumor cells exhibited TIC properties in vivo, were enriched in response to continuous cisplatin treatment, and showed activation of numerous major stem cell regulatory pathways. +other 30629937 hsa-mir-181a Tic Disorders We have found that an miR-181a(high) subpopulation of cells sorted from primary ovarian tumor cells exhibited TIC properties in vivo, were enriched in response to continuous cisplatin treatment, and showed activation of numerous major stem cell regulatory pathways. +lncRNA target 30629798 hsa-mir-128 Osteosarcoma 3p/VEGFC axis contributes to OS progression and may be used as a novel therapeutic target for OS. +circulation_biomarker_diagnosis_ns 30629727 hsa-mir-4667 Glaucoma Twenty circulating miRNAs were at least 1.5-fold higher in glaucoma or XFS patients than in controls across two ethnic cohorts: miR +circulation_biomarker_diagnosis_ns 30629727 hsa-mir-1306 Glaucoma Twenty circulating miRNAs were at least 1.5-fold higher in glaucoma or XFS patients than in controls across two ethnic cohorts: miR +circulation_biomarker_diagnosis_ns 30629727 hsa-mir-3159 Glaucoma Twenty circulating miRNAs were at least 1.5-fold higher in glaucoma or XFS patients than in controls across two ethnic cohorts: miR +circulation_biomarker_diagnosis_ns 30629727 hsa-mir-4724 Glaucoma Twenty circulating miRNAs were at least 1.5-fold higher in glaucoma or XFS patients than in controls across two ethnic cohorts: miR +circulation_biomarker_diagnosis_ns 30629727 hsa-mir-4767 Glaucoma Twenty circulating miRNAs were at least 1.5-fold higher in glaucoma or XFS patients than in controls across two ethnic cohorts: miR +circulation_biomarker_diagnosis_ns 30629727 hsa-mir-4538 Glaucoma Twenty circulating miRNAs were at least 1.5-fold higher in glaucoma or XFS patients than in controls across two ethnic cohorts: miR +circulation_biomarker_diagnosis_ns 30629727 hsa-mir-4725 Glaucoma Twenty circulating miRNAs were at least 1.5-fold higher in glaucoma or XFS patients than in controls across two ethnic cohorts: miR +circulation_biomarker_diagnosis_ns 30629727 hsa-mir-99b Glaucoma Twenty circulating miRNAs were at least 1.5-fold higher in glaucoma or XFS patients than in controls across two ethnic cohorts: miR +circulation_biomarker_diagnosis_ns 30629727 hsa-mir-190 Glaucoma Twenty circulating miRNAs were at least 1.5-fold higher in glaucoma or XFS patients than in controls across two ethnic cohorts: miR +circulation_biomarker_diagnosis_ns 30629727 hsa-mir-3913 Glaucoma Twenty circulating miRNAs were at least 1.5-fold higher in glaucoma or XFS patients than in controls across two ethnic cohorts: miR +circulation_biomarker_diagnosis_ns 30629727 hsa-mir-433 Glaucoma Twenty circulating miRNAs were at least 1.5-fold higher in glaucoma or XFS patients than in controls across two ethnic cohorts: miR +circulation_biomarker_diagnosis_ns 30629727 hsa-mir-3173 Glaucoma Twenty circulating miRNAs were at least 1.5-fold higher in glaucoma or XFS patients than in controls across two ethnic cohorts: miR +circulation_biomarker_diagnosis_ns 30629727 hsa-mir-637 Glaucoma Twenty circulating miRNAs were at least 1.5-fold higher in glaucoma or XFS patients than in controls across two ethnic cohorts: miR +circulation_biomarker_diagnosis_ns 30629727 hsa-mir-23b Glaucoma Twenty circulating miRNAs were at least 1.5-fold higher in glaucoma or XFS patients than in controls across two ethnic cohorts: miR +circulation_biomarker_diagnosis_ns 30629727 hsa-mir-4490 Glaucoma Twenty circulating miRNAs were at least 1.5-fold higher in glaucoma or XFS patients than in controls across two ethnic cohorts: miR +circulation_biomarker_diagnosis_ns 30629727 hsa-mir-4448 Glaucoma Twenty circulating miRNAs were at least 1.5-fold higher in glaucoma or XFS patients than in controls across two ethnic cohorts: miR +circulation_biomarker_diagnosis_ns 30629727 hsa-mir-608 Glaucoma Twenty circulating miRNAs were at least 1.5-fold higher in glaucoma or XFS patients than in controls across two ethnic cohorts: miR +circulation_biomarker_diagnosis_ns 30629727 hsa-mir-181b Glaucoma Twenty circulating miRNAs were at least 1.5-fold higher in glaucoma or XFS patients than in controls across two ethnic cohorts: miR +genetics_GWAS 30629480 hsa-mir-3691 Heart Septal Defects, Ventricular 3p target sequence single-nucleotide polymorphisms (SNPs) in the 3' untranslated region of the NOTCH1 gene. +lncRNA target 30628842 hsa-mir-1 Squamous Cell Carcinoma of Head and Neck The effects of miR-31 on the proliferation and invasion of HNSCC cells were explored through transfecting miR-31 analogs (miR-31 mimics) and miR-31 inhibitors (anti-miR-31). +genetics_knock down_promote 30628716 hsa-mir-29a Osteochondritis Dissecans AQP4 was the target of miR29a, which suppressed AQP4 expression, and knockdown of AQP4 mitigated OGDinduced astrocyte injury. +transcription factor target 30628716 hsa-mir-29a Hypoxia-Ischemia, Brain Thus, miR29a may protect primary cultured astrocytes after OGDinduced injury by targeting AQP4, and may be a potential therapeutic target for ischemic injury of astrocytes. +genetics_overexpression_promote 30628702 hsa-mir-758 Squamous Cell Carcinoma of Head and Neck Moreover, restored MTDH expression significantly counteracted the suppressive effects of miR758 overexpression on TSCC cells. +transcription factor target 30628701 hsa-mir-625 Asthma Therefore, miR6255p may function as an inhibitor of asthma airway inflammation in HBECs by targeting AKT2. +genetics_overexpression_promote 30628697 hsa-mir-577 Carcinoma, Non-Small-Cell Lung Notably, restored HOXA1 expression abrogated the reduced proliferation and invasion of NSCLC cells caused by miR577 overexpression. +genetics_overexpression_promote 30628692 hsa-mir-192 Colonic Neoplasms By overexpressing miR192 in colon cancer HCT116 cells, the results of the present study revealed that miR192 inhibits cell proliferation, migration and invasion. +genetics_overexpression_promote 30628685 hsa-mir-744 Thyroid Cancer, Papillary NOB1 overexpression could counteract miR744mediated antitumor effects on PTC cells. +genetics_overexpression_promote 30628668 hsa-mir-20b Brain Ischemia Additionally, the overexpression of miRNA20b increased the levels of adenosine 5'triphosphate (ATP) and reactive oxygen species (ROS) in the cerebral ischemia group, which were decreased following the downregulation of miRNA20b. +lncRNA target 30628663 hsa-mir-505 Carcinoma, Non-Small-Cell Lung Collectively, the data revealed the novel role and target of miR505 in NSCLC cells, which may provide novel insights regarding its role in the carcinogenesis of NSCLC and its potential values for clinical applications. +lncRNA target 30628646 hsa-mir-150 Breast Neoplasms miR1505p mimics decreased the cell proliferation, migration and invasion of BC cells. Collectively, the present results demonstrated the role of the FOXD2AS1/miR1505p/PFN2 axis in the development of BC, and provides novel targets for the treatment of BC, and potential biomarkers for diagnosis and prognosis of BC. +transcription factor target 30628644 hsa-mir-584 Carcinoma, Non-Small-Cell Lung Taken together, these results indicated that the miR5845p/MMP14 axis may serve as an anticancer target in the treatment of NSCLC patients. +genetics_knock down_promote 30628643 hsa-mir-664 Stomach Neoplasms Overexpression of miR36645P suppressed and miR36645P knockdown promoted the proliferation and metastasis of GC cells in vitro and in vivo. +genetics_overexpression_promote 30628638 hsa-mir-204 Lung Neoplasms Conversely, the overexpression of PCNA1 in A549 cells transfected with miR204 mimics promoted the proliferation, migration and invasion of lung cancer cells. +genetics_overexpression_promote 30628637 hsa-mir-20a Carcinoma, Endometrioid Reintroduction of IGF1R into miR320aoverexpressed cells antagonized the impact of miR320a on its downstream protein, which demonstrated that the tumor suppressive role of miR320a in endometrial carcinoma is exerted by the signal pathway mediated by IGF1R. +lncRNA target 30628487 hsa-mir-181d Carcinoma, Non-Small-Cell Lung In conclusion, this study highlights the tumor-suppressive effects of miR-181d-5p on NSCLC via Akt signaling pathway inactivation by suppressing CDKN3, thus providing a promising therapeutic strategy for the treatment of NSCLC. +genetics_knock down_suppress 30628484 hsa-let-7b Hypertension, Pulmonary Since let-7b knockout alleviated the development of HPH, let-7b may serve as a potential clinical target for the treatment of HPH. +exosome 30628018 hsa-mir-124 Brain Injuries, Traumatic However, whether miR-124 enriched exosomes (Exo-miR-124) can regulate the polarization of microglia and affect hippocampus neurogenesis after traumatic brain injury (TBI) is unknown. +lncRNA target 30627556 hsa-mir-17 Embolic Stroke "Furthermore, miR-15a-5p and miR5p may function through ""cell cycle, prostate cancer, and small cell lung cancer"" while miR-19b-3p and miR-20a-5p function through ""insulin resistance, hepatitis B, and viral carcinogenesis"" and ""vasopressin-regulated water reabsorption"", respectively." +lncRNA target 30627556 hsa-mir-17 Thrombotic Stroke "Furthermore, miR-15a-5p and miR5p may function through ""cell cycle, prostate cancer, and small cell lung cancer"" while miR-19b-3p and miR-20a-5p function through ""insulin resistance, hepatitis B, and viral carcinogenesis"" and ""vasopressin-regulated water reabsorption"", respectively." +lncRNA target 30627556 hsa-mir-20a Embolic Stroke "Furthermore, miR-15a-5p and miR5p may function through ""cell cycle, prostate cancer, and small cell lung cancer"" while miR-19b-3p and miR-20a-5p function through ""insulin resistance, hepatitis B, and viral carcinogenesis"" and ""vasopressin-regulated water reabsorption"", respectively." +lncRNA target 30627556 hsa-mir-19b Thrombotic Stroke "Furthermore, miR-15a-5p and miR5p may function through ""cell cycle, prostate cancer, and small cell lung cancer"" while miR-19b-3p and miR-20a-5p function through ""insulin resistance, hepatitis B, and viral carcinogenesis"" and ""vasopressin-regulated water reabsorption"", respectively." +lncRNA target 30627556 hsa-mir-20a Thrombotic Stroke "Furthermore, miR-15a-5p and miR5p may function through ""cell cycle, prostate cancer, and small cell lung cancer"" while miR-19b-3p and miR-20a-5p function through ""insulin resistance, hepatitis B, and viral carcinogenesis"" and ""vasopressin-regulated water reabsorption"", respectively." +lncRNA target 30627556 hsa-mir-15a Thrombotic Stroke "Furthermore, miR-15a-5p and miR5p may function through ""cell cycle, prostate cancer, and small cell lung cancer"" while miR-19b-3p and miR-20a-5p function through ""insulin resistance, hepatitis B, and viral carcinogenesis"" and ""vasopressin-regulated water reabsorption"", respectively." +lncRNA target 30627556 hsa-mir-19b Embolic Stroke "Furthermore, miR-15a-5p and miR5p may function through ""cell cycle, prostate cancer, and small cell lung cancer"" while miR-19b-3p and miR-20a-5p function through ""insulin resistance, hepatitis B, and viral carcinogenesis"" and ""vasopressin-regulated water reabsorption"", respectively." +lncRNA target 30627556 hsa-mir-15a Embolic Stroke "Furthermore, miR-15a-5p and miR5p may function through ""cell cycle, prostate cancer, and small cell lung cancer"" while miR-19b-3p and miR-20a-5p function through ""insulin resistance, hepatitis B, and viral carcinogenesis"" and ""vasopressin-regulated water reabsorption"", respectively." +lncRNA target 30627547 hsa-mir-34a Carcinoma, Hepatocellular Bioinformatics, Luciferase Reporter, RT-qPCR, and western blotting assays indicated that special AT-rich sequence-binding protein-2 (SATB2) is a direct target of miR-34a in HCC cells. +lncRNA target 30627542 hsa-mir-190a Uterine Cervical Neoplasms Three HPV16 oncoproteins (E5, E6, and E7) downregulate miR-148a-3p, while E6/E7 inhibit miR-199b-5p and miR-190a-5p expression in cervical carcinoma. +lncRNA target 30627542 hsa-mir-199b Uterine Cervical Neoplasms Three HPV16 oncoproteins (E5, E6, and E7) downregulate miR-148a-3p, while E6/E7 inhibit miR-199b-5p and miR-190a-5p expression in cervical carcinoma. +lncRNA target 30627542 hsa-mir-148a Uterine Cervical Neoplasms Three HPV16 oncoproteins (E5, E6, and E7) downregulate miR-148a-3p, while E6/E7 inhibit miR-199b-5p and miR-190a-5p expression in cervical carcinoma. +transcription factor target 30627419 hsa-mir-29a Carcinoma, Hepatocellular CONCLUSIONS: Our data indicated that XPD suppressed cell proliferation and migration via miR-29a-3p-Mdm2/PDGF-B axis in HCC. +circulation_biomarker_diagnosis_ns 30627229 hsa-mir-34a Drug-Related Side Effects and Adverse Reactions Conversely, miR-34a-5p showed increased levels in Tox plasma samples. +genetics_overexpression_promote 30626935 hsa-mir-29c Stomach Neoplasms Meanwhile, we illustrated that KIAA1199 was a target gene of miR-29c-3p and that miR-29c-3p overexpression led to decreased migration of GC cells in vitro and in vivo by suppressing the expression of KIAA1199 and several key proteins in the Wnt/beta-catenin and EGFR signaling pathways (e.g., WBP11, FGFR4, and PTP4A3). Taken together, these data demonstrate that KIAA1199 promotes GC metastasis by activating EMT-related signaling pathways and that miR-29c-3p regulates GC cell migration in vitro and in vivo by regulating KIAA1199 expression and activating the FGFR4/Wnt/beta-catenin and EGFR signaling pathways. +other 30626475 hsa-mir-451a Liver Neoplasms Methods Real-time quantitative PCR was utilized to detect the expression of miR-451a and MIF mRNA in clinical liver cancer tissues. Results The level of miR-451a was low and MIF mRNA was higher in liver cancer tissues. +lncRNA target 30626475 hsa-mir-451a Carcinoma, Hepatocellular Objective To investigate the regulatory effect of miR-451a on macrophage migration inhibitory factor (MIF) and its effect on the proliferation of hepatocellular carcinoma HepG2 cells. +other 30625382 hsa-mir-155 Nervous System Diseases Mechanistically, miR5p, which is known to destabilize barriers and tight junction proteins like claudin-1 and ZO-1, was increased in CCI and to lesser extent after rtPA application. +other 30625327 hsa-mir-9 high grade glioma Analyses of low-grade glioma patient samples indicate that the alternative-miR-9 has a potential role in tumor progression. +lncRNA target 30624964 hsa-mir-431 Enterocolitis, Necrotizing The level of microRNA (miR)-431 was found to be markedly up-regulated in intestinal tissue of necrotizing enterocolitis (NEC). Dysregulation of miR-431 and target gene FOXA1 in intestinal tissues of infants with necrotizing enterocolitis. +genetics_GWAS 30624803 hsa-mir-146a Hepatitis B, Chronic The present study investigated the association between miRNA-146a rs2910164 polymorphism and susceptibility to HBV infection in an Iranian population. +lncRNA target 30624782 hsa-mir-361 Osteosarcoma 5p inhibitor, pcDNA3.1-FoxM1, si-FoxM1, and negative control (NC) were, respectively, transfected into the osteosarcoma cells. +genetics_overexpression_promote 30624764 hsa-mir-135b Triple Negative Breast Neoplasms In addition, our study proved that the overexpression of miR-135b significantly suppressed APC expression by targeting the 3'-untranslated region of APC, whereas enhanced APC expression could partially abrogate the miR-135b-mediated promotion of carcinogenic traits in TNBC cells. +other 30623908 hsa-mir-20a Carcinoma, Hepatocellular OBJECTIVE: To determine the micro-ribonucleic acid-20a expression in hepatocellular carcinoma patients and its correlation with patients' demographic data, clinico-pathological and staging characteristics. CONCLUSIONS: Micro-ribonucleic acid-20a expression was found to be decreased in hepatocellular carcinoma patients with significant correlation with gender, age and alpha-fetoprotein level.. +other 30623862 hsa-mir-18 Multiple Sclerosis, Relapsing-Remitting CONCLUSION Upregulation of miR-18 during relapse in patients with RRMS points to a possible contribution to the pathogenesis of the inflammatory process in MS. +circRNA target 30623853 hsa-mir-103 Obesity On the other hand, miR-103 aggravated inflammation by inhibiting mitophagy, revealing that miR-103 acts as a positive regulator of adipose inflammation. +circRNA target 30623853 hsa-mir-103 Adiposis Dolorosa On the other hand, miR-103 aggravated inflammation by inhibiting mitophagy, revealing that miR-103 acts as a positive regulator of adipose inflammation. +genetics_overexpression_suppress 30623445 hsa-mir-614 Adenocarcinoma of Lung By combining predictor genes of six downregulated miRNAs and dysregulated genes of the WNT pathway, we inferred that overexpression of CHAP2 may inhibit LUAD cell proliferation and invasion via modulation of NFATC2 or GSK3B (WNT signal pathway) targeted by miR +circulation_biomarker_diagnosis_ns 30623425 hsa-mir-19b Myocardial Infarction, Acute CONCLUSION: Circulating miR-19b, miR-223, and miR +circulation_biomarker_diagnosis_ns 30623425 hsa-mir-483 Myocardial Infarction, Acute CONCLUSION: Circulating miR-19b, miR-223, and miR +circulation_biomarker_diagnosis_ns 30623425 hsa-mir-223 Myocardial Infarction, Acute CONCLUSION: Circulating miR-19b, miR-223, and miR +genetics_overexpression_suppress 30623419 hsa-mir-653 Neuroblastoma Importantly, the repressed NB progression induced by silenced SNHG7 was reversed by STAT2 overexpression or miR +genetics_overexpression_promote 30623409 hsa-mir-513 Carcinoma, Non-Small-Cell Lung HMGB3 was a target of miR-513b, and overexpression of HMGB3 could obviously reverse the effect of miR-513 on the proliferation, invasion, migration, and apoptosis of NSCLC cells ( p < 0.05). +genetics_overexpression_promote 30623409 hsa-mir-513b Carcinoma, Non-Small-Cell Lung HMGB3 was a target of miR-513b, and overexpression of HMGB3 could obviously reverse the effect of miR-513 on the proliferation, invasion, migration, and apoptosis of NSCLC cells ( p < 0.05). +genetics_overexpression_promote 30623409 hsa-mir-513b Lung Neoplasms HMGB3 was a target of miR-513b, and overexpression of HMGB3 could obviously reverse the effect of miR-513 on the proliferation, invasion, migration, and apoptosis of NSCLC cells ( p < 0.05). +genetics_overexpression_promote 30623409 hsa-mir-513 Lung Neoplasms HMGB3 was a target of miR-513b, and overexpression of HMGB3 could obviously reverse the effect of miR-513 on the proliferation, invasion, migration, and apoptosis of NSCLC cells ( p < 0.05). +other 30623320 hsa-mir-21 Colitis VSG-induced increases in colitis were associated with increased colonic expression of TNF-alpha, IL-6, MCP-1, and microRNA-21. +lncRNA target 30622796 hsa-mir-351 Muscular Atrophy miR-351 maybe a potential target for development of a new strategy for skeletal muscle atrophy. +circulation_biomarker_diagnosis_ns 30622793 hsa-mir-92b Heart Failure, Acute CONCLUSIONS: Exo-miR-92b-5p levels in the serum may serve as a marker for HFrEF diagnosis. +lncRNA target 30622671 hsa-mir-24 Reperfusion Injury 3p mimic or inhibitor to explore the role of miR +transcription factor target 30622615 hsa-mir-21 Anodontia The protective effects of TFs resulted in higher expression of miR-21 in H/R-induced H9c2 cells than that of controls, which in turn upregulated Akt signaling activity via suppressing the expression of PTEN together with decreasing the ratio of Bax/Bcl-2, caspase3, and cleaved-caspase3 expression in H/R-induced H9c2 cells. Conversely, blocking miR-21 expression with miR-21 inhibitor effectively suppressed the protective effects of TFs against H/R-induced injury. +other 30622599 hsa-mir-21 Fibrosis, Renal CONCLUSION: SKSF could attenuate the renal damage and renal fibrosis induced in T2DM, which may be related to its regulation on the expressions of TGF-beta1, PTEN, and miR-21. +other 30622599 hsa-mir-21 Diabetes Mellitus, Type 2 CONCLUSION: SKSF could attenuate the renal damage and renal fibrosis induced in T2DM, which may be related to its regulation on the expressions of TGF-beta1, PTEN, and miR-21. +circulation_biomarker_diagnosis_down 30622476 hsa-mir-29c Muscular Dystrophies Conclusion: In female MD carriers, down-regulation of circulating miR-29c relates to the presence of functional and/or structural cardiac abnormalities (as detected by CMR) and appears to be a promising novel biomarker-in addition to conventional CK plasma levels-for an early diagnosis of cardiomyopathy. +circulation_biomarker_diagnosis_down 30622476 hsa-mir-29c Cardiomyopathies Conclusion: In female MD carriers, down-regulation of circulating miR-29c relates to the presence of functional and/or structural cardiac abnormalities (as detected by CMR) and appears to be a promising novel biomarker-in addition to conventional CK plasma levels-for an early diagnosis of cardiomyopathy. +circulation_biomarker_diagnosis_ns 30622423 hsa-mir-200b Lung Neoplasms Therefore, these findings suggested that miR-200b may be used as a marker for the detection and diagnosis of lung cancer in peripheral blood. +lncRNA target 30622242 hsa-mir-145 Breast Neoplasms 5p expression in BC cells leads to Ago2 protein induction through the loosening of Ago2 mRNA translational repression. +other 30622178 hsa-mir-21 Melanoma A 22-nt anti-miR-21 mesyl phosphoramidate oligodeoxynucleotide specifically decreased the miR-21 level in melanoma B16 cells, induced apoptosis, reduced proliferation, and impeded migration of tumor cells, showing superiority over isosequential phosphorothioate oligodeoxynucleotide in the specificity of its biological effect. +genetics_overexpression_promote 30622052 hsa-mir-642b Squamous Cell Carcinoma of Head and Neck Finally, we demonstrated that overexpressed PRRX1 was closely correlated with miR-642b-3p downregulation and the upregulation of TGF-beta2 and p38 in a xenograft model of HNSCC. +lncRNA target 30622051 hsa-mir-503 Neoplasm Metastasis Taken together, these results suggest that high CD97 expression, which is controlled through the NF-kappaB/miR +lncRNA target 30622051 hsa-mir-503 Ovarian Neoplasms Taken together, these results suggest that high CD97 expression, which is controlled through the NF-kappaB/miR +lncRNA target 30621915 hsa-mir-155 Tuberculosis Altogether, our data indicate that PCED1B-AS1 modulates macrophage apoptosis and autophagy by targeting the miR-155 axis in active TB. +genetics_overexpression_suppress 30621914 hsa-mir-501 Prostatic Neoplasms 3p on prostate cancer cell growth was partially reversed by CREPT overexpression. +other 30621734 hsa-mir-6875 Carcinoma, Hepatocellular 3p can promote tumorigenesis of HCC in vitro and in vivo, so as to function as a novel oncogene in HCC. +other 30621721 hsa-mir-382 Glioma CONCLUSIONS: MOV10 / circ-DICER1 / miR-103a-3p (miR5p) / ZIC4 pathway plays a vital role in regulating the angiogenesis of glioma. +other 30621721 hsa-mir-103a Glioma CONCLUSIONS: MOV10 / circ-DICER1 / miR-103a-3p (miR5p) / ZIC4 pathway plays a vital role in regulating the angiogenesis of glioma. +lncRNA target 30621631 hsa-mir-196a Colorectal Neoplasms CONCLUSIONS: miR-196a-5p may play a key role in EMT, invasion and metastasis of CRC cells via targeting the IkappaBalpha. +other 30621516 hsa-mir-3677 Liver Cirrhosis RESULTS: Concentration of miR-3677 in GAVE-affected mucosa was higher by 72% in comparison with GAVE-free mucosa of patients with cirrhosis (33.7 vs. +other 30621516 hsa-mir-3677 Gastric Antral Vascular Ectasia RESULTS: Concentration of miR-3677 in GAVE-affected mucosa was higher by 72% in comparison with GAVE-free mucosa of patients with cirrhosis (33.7 vs. +transcription factor target 30621480 hsa-mir-155 Lung Neoplasms Identification and imaging of miR-155 in the early screening of lung cancer by targeted delivery of octreotide-conjugated chitosan-molecular beacon nanoparticles. The octreotide-conjugated chitosan-molecular beacon nanoparticles (CS-MB-OCT) can specifically bind to SSTR2 expressed by the lung cancer cells to achieve the goal of identification of lung cancer cells and imaging miR-155 in vivo and in vitro. +other 30619490 hsa-mir-144 Diabetes Mellitus, Type 2 3p in regulating adipogenesis was still unclear. +transcription factor target 30619490 hsa-mir-144 Obesity 3p could be a target for therapeutic intervention in obesity and metabolic syndrome in the future. +transcription factor target 30619490 hsa-mir-144 Metabolic Diseases 3p could be a target for therapeutic intervention in obesity and metabolic syndrome in the future. +lncRNA target 30619488 hsa-mir-146a Melanoma Two Ras-induced microRNAs (miR-146a and 193a) target Jmjd6, inducing downregulation of its mRNA and protein levels at the onset of Ras expression during melanoma development. +other 30619352 hsa-mir-1000 Lichen Sclerosus et Atrophicus In this study, the regulation of two white spot syndrome virus (WSSV) genes by its host (Marsupenaeus japonicus shrimp) miRNA (shrimp miR-1000) was characterized. +other 30619352 hsa-mir-1000 Werner Syndrome In this study, the regulation of two white spot syndrome virus (WSSV) genes by its host (Marsupenaeus japonicus shrimp) miRNA (shrimp miR-1000) was characterized. +other 30619270 hsa-mir-146a Environmental Illness In contrast, IL-1beta-induced MIR3142HG expression, and its metabolism to miR-146a, was reduced by 4- and 9-fold in IPF fibroblasts, respectively. In summary, we have cataloged those lncRNAs that are differentially expressed following IL-1beta-activation of human lung fibroblasts, shown that IL7AS and MIR3142HG regulate the inflammatory response and demonstrated that the reduced inflammatory response in IPF fibroblast is correlated with attenuated expression of MIR3142HG/miR-146a. +lncRNA target 30618730 hsa-mir-188 Carcinoma, Non-Small-Cell Lung Taken together, our study demonstrated that miR-3188 interacts with mTOR and FOXO1 to inhibit NSCLC cell proliferation through a mTOR-p-PI3K/AKT-c-JUN signaling pathway. +lncRNA target 30618618 hsa-mir-132 Ischemic Stroke In conclusion, EA enhances neurobehavioral functional recovery against ischemic stroke through targeting of SOX2-mediated axonal regeneration by miR-132. +lncRNA target 30618601 hsa-mir-22 Status Epilepticus MicroRNA-22 inhibition also reduced the length and complexity of the dendritic tree, independently of SE. +other 30618167 hsa-mir-527 Lung Neoplasms Taken together, our study found a novel signaling pathway, namely MNX1-AS1/miR-527/BRF2 axis, involved in lung cancer progression. +other 30618100 hsa-mir-146a Acute Coronary Syndrome In this case-control study, we explored the role of the inflammatory microRNA, miR-146a, in acute coronary syndrome (ACS) subjects with and without chronic periodontitis (CP) and its regulation of the innate immune host response to periodontal pathogens. CONCLUSION: microRNA-146a is a key molecule associating periodontitis with acute coronary syndrome. +transcription factor target 30618075 hsa-mir-375 Cardiomegaly 3p inhibitor suppresses Ang II-induced cardiomyocyte hypertrophy by promoting LDHB expression. +circulation_biomarker_diagnosis_ns 30617992 hsa-mir-17 Ischemic Stroke Together, altered circulating EV levels of miRNA-17 family members may reflect the chronic sequelae underlying cerebrovascular SVD rather than the acute ischemic stroke itself. +circulation_biomarker_diagnosis_ns 30617992 hsa-mir-17 Cerebral Small Vessel Diseases Together, altered circulating EV levels of miRNA-17 family members may reflect the chronic sequelae underlying cerebrovascular SVD rather than the acute ischemic stroke itself. +lncRNA target 30617305 hsa-mir-203 Adenocarcinoma of Lung In conclusion, the CAR10/miR-30/203/SNAI axis is a novel and potential therapeutic target for LUAD. +lncRNA target 30617215 hsa-mir-22 Hematologic Neoplasms Dysregulation of miR-22 leads to various hematologic malignancies and disorders, but its role in hematopoiesis is not yet well established. +genetics_knock down_promote 30617187 hsa-mir-1254 Carcinoma, Hepatocellular Moreover, DCST1-AS1 knockout significantly inhibited proliferation, promoted apoptosis and cycle arrest of HCC cells, and inhibited tumour growth in vivo According to functional analysis, DCST1-AS1 competitively bound miR-1254, thus blocking the silencing effect of miR-1254 on the target gene Fas apoptosis inhibitor 2 (FAIM2). DCST1-AS1 up-regulates the expression of FAIM2 by up-regulating the expression of miR-1254, ultimately promoting the proliferation of HCC cells. +genetics_knock down_promote 30617160 hsa-mir-155 Tongue Neoplasms Ectopic expression of Pdcd4 or knockdown of miR-155 in tongue cancer cells predominantly reduces AP +lncRNA target 30617054 hsa-mir-34a Pneumonia, Mycoplasma Taken together, these findings suggest that inhibition of miR-34a-5p improves invasion and migration of trophoblast cells by directly targetting Smad4, which indicated the potential of miR-34a-5p as a therapeutic target against PE. +genetics_knock down_suppress 30616889 hsa-mir-584 Colorectal Neoplasms 3p could reverse the effects of LOC101927746 knockdown in CRC cells. +genetics_GWAS 30616633 hsa-mir-206 Hirschsprung Disease We aimed to investigate the effect of miRNA-206 and its targets, fibronectin 1 (FN1), serum deprivation response (SDPR), and paired box 3 (PAX3) expressions on multifactorial HSCR in Indonesia, a genetically distinct group within Asia. METHODS We determined the miRNA-206, FN1, SDPR and PAX3 expressions in both the ganglionic and aganglionic colon of HSCR patients and control colon by quantitative real-time polymerase chain reaction (qRT-PCR). +lncRNA target 30616540 hsa-mir-145 Prostatic Neoplasms The top performer was BUB1, one of four key MIR145-3P microRNA targets upregulated in hormone-sensitive as well as castration-resistant PCa. +transcription factor target 30616374 hsa-mir-17 Rhinitis, Allergic, Seasonal Besides, MIR5P might also act in SAR via targeting ABCA1 and CD69. +other 30616103 hsa-mir-223 Leukemia, Myeloid, Acute Our study indicates that a molecular network involving MOZ and miR-223 contributes to the monocyte differentiation and polarization program, which is deregulated in AML. +other 30616081 hsa-mir-16 Carcinoma, Renal Cell High miR-16 level was also associated with shorter survival time in ccRCC. +other 30615927 hsa-mir-146a Pulmonary Disease, Chronic Obstructive Therefore, these results demonstrate the potential of PGA-co-PDL NPs as a delivery system for miR-146a to treat COPD. +other 30615885 hsa-mir-7702 Uveal melanoma As a result, a linear prognostic model consisting of 9 miRNAs (miR-195, miR-224, miR-365a, miR-365b, miR-452, miR-4709, miR-7702, miR-513c, miR-873) was developed to divide UM patients into a high- and a low-risk group. +other 30615885 hsa-mir-365b Uveal melanoma As a result, a linear prognostic model consisting of 9 miRNAs (miR-195, miR-224, miR-365a, miR-365b, miR-452, miR-4709, miR-7702, miR-513c, miR-873) was developed to divide UM patients into a high- and a low-risk group. +other 30615885 hsa-mir-513c Uveal melanoma As a result, a linear prognostic model consisting of 9 miRNAs (miR-195, miR-224, miR-365a, miR-365b, miR-452, miR-4709, miR-7702, miR-513c, miR-873) was developed to divide UM patients into a high- and a low-risk group. +other 30615885 hsa-mir-4709 Uveal melanoma As a result, a linear prognostic model consisting of 9 miRNAs (miR-195, miR-224, miR-365a, miR-365b, miR-452, miR-4709, miR-7702, miR-513c, miR-873) was developed to divide UM patients into a high- and a low-risk group. +other 30615885 hsa-mir-873 Uveal melanoma As a result, a linear prognostic model consisting of 9 miRNAs (miR-195, miR-224, miR-365a, miR-365b, miR-452, miR-4709, miR-7702, miR-513c, miR-873) was developed to divide UM patients into a high- and a low-risk group. +other 30615885 hsa-mir-452 Uveal melanoma As a result, a linear prognostic model consisting of 9 miRNAs (miR-195, miR-224, miR-365a, miR-365b, miR-452, miR-4709, miR-7702, miR-513c, miR-873) was developed to divide UM patients into a high- and a low-risk group. +other 30615885 hsa-mir-365a Uveal melanoma As a result, a linear prognostic model consisting of 9 miRNAs (miR-195, miR-224, miR-365a, miR-365b, miR-452, miR-4709, miR-7702, miR-513c, miR-873) was developed to divide UM patients into a high- and a low-risk group. +other 30615885 hsa-mir-224 Uveal melanoma As a result, a linear prognostic model consisting of 9 miRNAs (miR-195, miR-224, miR-365a, miR-365b, miR-452, miR-4709, miR-7702, miR-513c, miR-873) was developed to divide UM patients into a high- and a low-risk group. +other 30615885 hsa-mir-195 Uveal melanoma As a result, a linear prognostic model consisting of 9 miRNAs (miR-195, miR-224, miR-365a, miR-365b, miR-452, miR-4709, miR-7702, miR-513c, miR-873) was developed to divide UM patients into a high- and a low-risk group. +transcription factor target 30615846 hsa-mir-548ah Hepatitis B The effect of miRNA-548ah on its target gene, histone deacetylase (HDAC) 4, were confirmed in in vitro studies and further investigated in liver tissues from CHB patients. Finally, we observed a negative correlation between the expression of miRNA-548ah and HDAC4 in the liver tissue of patients with CHB. +other 30615673 hsa-mir-181b Central Nervous System Neoplasms Furthermore, three miRNAs including miR-181b, miR-30d, and miR-93, selected from the 16 miRNAs, also showed comparable results for survival (HR = 8.9342, P = 0.0007), suggestive of a miRNA signature for prognostic prediction in PCNSL. +other 30615673 hsa-mir-93 Central Nervous System Neoplasms Furthermore, three miRNAs including miR-181b, miR-30d, and miR-93, selected from the 16 miRNAs, also showed comparable results for survival (HR = 8.9342, P = 0.0007), suggestive of a miRNA signature for prognostic prediction in PCNSL. +epigenetics 30615358 hsa-mir-9 Carcinoma, Renal Cell Furthermore, it is demonstrated that hyper-methylation of 5 genes of micro-RNA (miR +epigenetics 30615358 hsa-mir-129-2 Carcinoma, Renal Cell The hyper-methylation of gene miR2 is a new efficient marker of prognosis of metastasis disease (sensitivity 75% and specificity 79%, AUC 0.77) that can be combined with markers discovered in other studies. +epigenetics 30615358 hsa-mir-9-1 Carcinoma, Renal Cell Furthermore, it is demonstrated that hyper-methylation of 5 genes of micro-RNA (miR +epigenetics 30615358 hsa-mir-34b Carcinoma, Renal Cell Furthermore, it is demonstrated that hyper-methylation of 5 genes of micro-RNA (miR +epigenetics 30615358 hsa-mir-124a-1 Carcinoma, Renal Cell Furthermore, it is demonstrated that hyper-methylation of 5 genes of micro-RNA (miR +epigenetics 30615358 hsa-mir-34c Carcinoma, Renal Cell Furthermore, it is demonstrated that hyper-methylation of 5 genes of micro-RNA (miR +epigenetics 30615358 hsa-mir-32 Carcinoma, Renal Cell Furthermore, it is demonstrated that hyper-methylation of 5 genes of micro-RNA (miR +genetics_knock down_suppress 30615274 hsa-mir-18a Retinal Diseases Finally, tgif1 mutants have increased miR-18a expression, less NeuroD protein and fewer mature photoreceptors, and the photoreceptor deficiency is rescued by miR-18a knockdown. +genetics_knock down_suppress 30615274 hsa-mir-18 Retinal Diseases Finally, tgif1 mutants have increased miR-18a expression, less NeuroD protein and fewer mature photoreceptors, and the photoreceptor deficiency is rescued by miR-18a knockdown. +genetics_overexpression_promote 30615124 hsa-mir-185 Inflammatory Bowel Diseases Furthermore, CCAT1-induced MLCK overexpression and IBD disease progression were significantly attenuated by miR +lncRNA target 30614908 hsa-mir-106b Wallerian Degeneration Taken together, these findings suggest that the expression of EGR2 during postnatal development and Wallerian degeneration could be regulated by the inverse expression of miRNAs 106b-5p, 140-5p, 93-5p, and 17-5p, which target EGR2. +transcription factor target 30614803 hsa-mir-124 Urinary Bladder Neoplasms 3p directly targets ITGA3, and western blot suggested that miR +transcription factor target 30614802 hsa-mir-28 Lung Neoplasms Suppression of miR-328 level promotes lung cancer tissue apoptosis, which provides novel target for lung cancer therapy. +genetics_knock down_promote 30614794 hsa-mir-27a Ovarian Neoplasms The function of miR-27a in ovarian cancer was investigated through overexpression and knockdown of miR-27a in vitro. +lncRNA target 30614351 hsa-mir-139 Carcinoma, Non-Small-Cell Lung 5p may act as a tumor suppressor gene in the occurrence and development of NSCLC. +other 30614256 hsa-mir-451a Diabetic Nephropathies Mesenchymal stem cells-microvesicle-miR-451a ameliorate early diabetic kidney injury by negative regulation of P15 and P19. +lncRNA target 30613973 hsa-mir-30 Prostatic Neoplasms 5p to inhibit EMT, invasion and migration of PCa by LEF1 repression. +genetics_knock down_promote 30613290 hsa-mir-125b Myocardial Infarction Administration of miR-125b knockdown Hypo-Exo significantly increased the infarction area and suppressed cardiomyocyte survival post-MI. +genetics_knock down_promote 30613269 hsa-mir-203 Adenocarcinoma of Lung In lung adenocarcinoma cell lines, BPI-9016M treatment resulted in increased miR203, which reduced migration and invasion and also repressed Dickkopf-related protein 1 (DKK1) expression. +lncRNA target 30613151 hsa-mir-562 Glioblastoma In addition, caspase-3 might also serve as another target for miR-562 in GBM cells. +circulation_biomarker_diagnosis_ns 30612555 hsa-mir-632 Stomach Neoplasms RESULTS: Our results showed that miR-632 is highly expressed in GC tissue and serum and negatively associated with TFF1 in GC. +other 30612280 hsa-mir-144 Atherosclerosis 5p and hsa-miR-133a-5p would have associated with presence of the CAD. +other 30612280 hsa-mir-133a Atherosclerosis 5p and hsa-miR-133a-5p would have associated with presence of the CAD. +other 30612280 hsa-mir-222 Atherosclerosis 5p and hsa-miR-133a-5p would have associated with presence of the CAD. +genetics_knock down_suppress 30612066 hsa-mir-20a Leukemia, Myeloid, Acute Further experiments in vitro and in vivo demonstrated that knockdown of circ_0009910 inhibited AML cell proliferation and induced apoptosis through sponging miR-20a-5p. Both circ_0009910 and miR-20a-5p may be potential therapeutic targets for future AML treatment. +other 30612004 hsa-mir-377 Reperfusion Injury, Renal Ischemia Furthermore, vascular endothelial growth factor (VEGF) depletion by siRNA completely abrogated the impact of miR-377 on renal I/R-induced oxidative stress, inflammation and renal dysfunction. In conclusion, renal I/R induced miR-377 expression, which upregulated VEGF expression to attenuate renal I/R-induced oxidative stress and inflammation, and finally ameliorated renal dysfunction. +genetics_overexpression_promote 30611999 hsa-mir-146a Influenza, Human In addition, we found that miR-146a directly targets tumor necrosis factor receptor association factor 6 (TRAF6), which is involved in the production of type I IFN, and TRAF6 overexpression reversed the replication-promoting effect of miR-146a on IAV. +other 30611662 hsa-mir-219 Spinal Cord Injuries Using spinal cord injury as a proof-of-concept, we further demonstrate that miR-219/miR-338 could also be delivered non-virally in vivo using an aligned fiber-hydrogel scaffold to enhance remyelination after a hemi-incision injury at C5 level of Sprague-Dawley rats. +other 30611662 hsa-mir-338 Spinal Cord Injuries Using spinal cord injury as a proof-of-concept, we further demonstrate that miR-219/miR-338 could also be delivered non-virally in vivo using an aligned fiber-hydrogel scaffold to enhance remyelination after a hemi-incision injury at C5 level of Sprague-Dawley rats. +genetics_overexpression_suppress 30611621 hsa-mir-124 Triple Negative Breast Neoplasms Overexpression of miR-124 inhibited the proliferation, metastasis and epithelial-mesenchymal transition (EMT) of TNBC cells. +lncRNA target 30611620 hsa-mir-206 Uterine Cervical Neoplasms Our findings revealed that SNHG14 acted as a sponge of miR-206 to regulate the expression of YWHAZ in CC, hinting the promising therapeutic target role of SNHG4 for CC patients. +lncRNA target 30611568 hsa-mir-141 Carcinoma, Non-Small-Cell Lung 3p might be a prognostic tumor suppressor involved in the NSCLC progression. +genetics_GWAS 30611259 hsa-mir-146a Melanoma Expression level of hsa-miR-146a-5p showedto be higher in melanoma cells as compared to thehealthy adjacent skin. The 38 target genes have been shown for miR-146a-5p of which NRAS gene is known asone of the most frequent mutated in melanoma. +circulation_biomarker_prognosis_ns 30611212 hsa-mir-1 Myocardial Infarction, Acute CONCLUSIONS: Circulating microRNA-1 might diagnose early AMI and predict the prognosis of patients with chest pain. +lncRNA target 30610808 hsa-mir-199b Osteosarcoma Furthermore, we found that miR-199b-5p promoted the progression of OS mainly through regulating HER2. +genetics_overexpression_suppress 30610793 hsa-mir-150 Nasopharyngeal Carcinoma MiR150 inhibitor was used to treat NPC cells, and FOXO4 overexpression cell lines were established. +lncRNA target 30610787 hsa-mir-421 Colorectal Neoplasms Therefore, the miR-421/MAT1 axis is expected to be one of the targets of CRC targeted therapy. +circulation_biomarker_diagnosis_ns 30610670 hsa-mir-1 Coronary Artery Disease Upregulation of circulating miR-1 and miR-133 associate with the risk of CAD in T2D patients and may serve as diagnostic biomarkers. +circulation_biomarker_diagnosis_ns 30610670 hsa-mir-133 Coronary Artery Disease Upregulation of circulating miR-1 and miR-133 associate with the risk of CAD in T2D patients and may serve as diagnostic biomarkers. +circulation_biomarker_diagnosis_ns 30610670 hsa-mir-133 Diabetes Mellitus, Type 2 Upregulation of circulating miR-1 and miR-133 associate with the risk of CAD in T2D patients and may serve as diagnostic biomarkers. +circulation_biomarker_diagnosis_ns 30610670 hsa-mir-1 Diabetes Mellitus, Type 2 Upregulation of circulating miR-1 and miR-133 associate with the risk of CAD in T2D patients and may serve as diagnostic biomarkers. +lncRNA target 30610161 hsa-mir-431 Lung Neoplasms Together, these results indicated that FBXL19-AS1 was involved in progression and angiogenesis in lung cancer by targeting miR +other 30610047 hsa-mir-7 Lung Diseases, Interstitial However, only miR-7 was the sole miRNA lower expression in each IIM patient (P<0.05), which is also lower expression in IIM/ILD patients than that without ILD (P<0.05). Further, AUC analysis showes both miR-7 and miR-21 have diagnostic value as biomarkers for IIM patients form health controls; however, miR-7 is more sensitive CONCLUSION: miR-7 is a potential biomarker as a diagnostic indicator for IIM patients and can be used to distinguish IIM/ILD patients from IIM without ILD. +lncRNA target 30610041 hsa-mir-196b Glioma Together, our findings indicate that downregulation of miR-196b increased glioma cell sensitivity to temozolomide chemotherapy and radiotherapy and may be a valuable target when treating malignant gliomas. +transcription factor target 30609807 hsa-mir-125b-2 Infertility, Male The study indicated that miR-125b-2 had a positive influence on the reproductive performance of animals by regulating the expression of the PAP gene, and could be a potential drugs and diagnostic target for male infertility. +transcription factor target 30609807 hsa-mir-125b Infertility, Male The study indicated that miR-125b-2 had a positive influence on the reproductive performance of animals by regulating the expression of the PAP gene, and could be a potential drugs and diagnostic target for male infertility. +lncRNA target 30609030 hsa-mir-455 Urinary Bladder Neoplasms We demonstrated OXCT1-AS1 inhibited miR5p to decrease its binding to the JAK1 3'-untranslated region, which could upregulate the expression of JAK1 at the protein level, thus promoting BCa proliferation and invasion. +other 30608951 hsa-mir-7641 Colorectal Neoplasms Our findings suggest that EV miRNA profiles from CRC cell lines may allow prediction of CRC tumours, and that miR-7641 may serve as an attractive candidate for the specific, non-invasive diagnosis and prognosis of CRC. +circulation_biomarker_diagnosis_ns 30608133 hsa-mir-10b Urinary Bladder Neoplasms The unprecedentedly high sensitivity of nanoplasmonic sensors has allowed us to assay four different microRNAs (microRNA-10b, -182, -143, and -145) from bladder cancer patient plasma (50 muL/sample). +other 30608062 hsa-mir-5193 Prostatic Neoplasms However, the roles of TRIM11 and miRNA-5193 in prostate cancer remain unknown. This study aimed to investigate the regulatory effects of miRNA-5193 on the expression of TRIM11 in prostate cancer tissues compared with adjacent normal prostate, and in human prostate cancer cell lines, PC3 and DU145 in vitro. +circulation_biomarker_diagnosis_ns 30607665 hsa-mir-150 Atrial Fibrillation Among the AF ablation cases, miRNA-150 was lower for those with AF recurrences at 1 year (adjusted OR=0.98 per 500,000 fmol/l; 95% CI=0.965, 0.998; p=0.039). Circulating miRNA-150 was significantly associated with a reduction in 1-year AF recurrence post ablation suggestive of adverse structural and electrical remodeling as recurrence mechanisms. +other 30607582 hsa-mir-451a Uterine Cervical Neoplasms CONCLUSION: E2F7, EREG, miR-451a and miR-106b-5p were likely to be related to the cervical cancer development. +other 30607582 hsa-mir-106b Uterine Cervical Neoplasms CONCLUSION: E2F7, EREG, miR-451a and miR-106b-5p were likely to be related to the cervical cancer development. +other 30607541 hsa-mir-19b-1 Heart Failure Together, these results revealed an essential role of miR-19b-1 in ischaemia-induced heart failure. +other 30607541 hsa-mir-19b-1 Heart Failure, Ischemic Together, these results revealed an essential role of miR-19b-1 in ischaemia-induced heart failure. +lncRNA target 30607520 hsa-mir-181a Stomach Neoplasms The present study suggests that miR-181a is a novel negative regulator of TGFbetaR2 in the TGF-beta signaling pathway and thus represents a potential new therapeutic target for gastric cancer. +lncRNA target 30607158 hsa-mir-497 Triple Negative Breast Neoplasms RESULTS: Bioinformatic analysis predicted that microRNA (miR)-93, miR-195, miR-497, and miR-340 are potential regulators of the immune evasion of breast cancer cells, and that they exert this function by targeting CD274, PDCD1LG2, and NCR3LG1. CONCLUSION: Our data indicated that the level of B7 family members can predict the prognosis of breast cancer patients, and miR-195/miR-497 regulate CD274 expression in triple negative breast cancer. +lncRNA target 30607158 hsa-mir-195 Triple Negative Breast Neoplasms RESULTS: Bioinformatic analysis predicted that microRNA (miR)-93, miR-195, miR-497, and miR-340 are potential regulators of the immune evasion of breast cancer cells, and that they exert this function by targeting CD274, PDCD1LG2, and NCR3LG1. CONCLUSION: Our data indicated that the level of B7 family members can predict the prognosis of breast cancer patients, and miR-195/miR-497 regulate CD274 expression in triple negative breast cancer. +other 30606694 hsa-mir-92a Alzheimer Disease 5p) as key signaling and regulatory molecules associated with transcriptional changes for the AD. +other 30606694 hsa-mir-335 Alzheimer Disease 5p) as key signaling and regulatory molecules associated with transcriptional changes for the AD. +other 30606694 hsa-mir-93 Alzheimer Disease 5p) as key signaling and regulatory molecules associated with transcriptional changes for the AD. +other 30606694 hsa-mir-26b Alzheimer Disease 5p) as key signaling and regulatory molecules associated with transcriptional changes for the AD. +other 30606694 hsa-mir-192 Alzheimer Disease 5p) as key signaling and regulatory molecules associated with transcriptional changes for the AD. +other 30606694 hsa-mir-17 Alzheimer Disease 5p) as key signaling and regulatory molecules associated with transcriptional changes for the AD. +other 30606694 hsa-mir-20a Alzheimer Disease 5p) as key signaling and regulatory molecules associated with transcriptional changes for the AD. +other 30606694 hsa-mir-16 Alzheimer Disease 5p) as key signaling and regulatory molecules associated with transcriptional changes for the AD. +lncRNA target 30606659 hsa-mir-23a Squamous Cell Carcinoma of Head and Neck Using in vitro approaches we ascertained that miR-23a-3p might contribute to the inhibition of growth and inhibition through increasing apoptosis in OSCC cells; while an inhibitor of miR-23a-3p could reverse this effect. +other 30605882 hsa-mir-488 Carcinoma, Non-Small-Cell Lung PYCR1 is negatively regulated by miR-488 and then promotes the occurrence and development of NSCLC and activates p38 MAPK pathway. +transcription factor target 30605519 hsa-mir-484 Breast Neoplasms Through conditional modulation of these miRNAs in breast cancer cells, we demonstrate that miRNAs 484 and 210 inhibit Pax-5 expression and regulate Pax +lncRNA target 30605240 hsa-mir-3 Vitamin B Deficiency 3p, which targets ADAM10. +lncRNA target 30605239 hsa-mir-101 Cardiomegaly Collectively, these in vivo and in vitro findings identify XIST as a necessary regulator of cardiac hypertrophy due to its regulation of the miR-101/TLR2 axis, suggesting that XIST might act as a therapeutic target for the treatment of cardiac hypertrophy and heart failure. +other 30605234 hsa-mir-224 Polycystic Ovary Syndrome Intraovarian injection of miR-224 as a marker of polycystic ovarian syndrome declines oocyte competency and embryo development. miR-224 is associated with polycystic ovary syndrome (PCOS) that is an epidemic in reproductive age women. +genetics_GWAS 30605069 hsa-mir-1206 Leukemia, Myelogenous, Chronic, BCR-ABL Positive CONCLUSION: In conclusion, we discovered the association of SNP rs2114358 in miR-1206 with the risk of CML patients, though more investigations are still required to understand the regulative mechanisms of this miR SNP with the target genes resulting in its dysregulation. +other 30604907 hsa-mir-145 Bulimia Nervosa Our results reveal a comprehensive pathway that p52 acts as a positive regulator of BC invasion by initiating a novel miR-145/Sp1/USP8/AUF1/RhoGDIbeta axis. +lncRNA target 30604866 hsa-mir-129 Carcinoma, Renal Cell In conclusion, our findings reveal that TSAIII inhibits the metastatic properties of RCC cells, contributing to the inhibition of PI3K/AKT and the increase of miR +circulation_biomarker_diagnosis_ns 30604797 hsa-mir-192 Lung Neoplasms We found that EVs isolated from the plasma of lung cancer patients contained higher levels of miR-21, miR-191 and miR-192 compared to those from healthy people. +circulation_biomarker_diagnosis_ns 30604797 hsa-mir-21 Lung Neoplasms We found that EVs isolated from the plasma of lung cancer patients contained higher levels of miR-21, miR-191 and miR-192 compared to those from healthy people. +circulation_biomarker_diagnosis_ns 30604797 hsa-mir-191 Lung Neoplasms We found that EVs isolated from the plasma of lung cancer patients contained higher levels of miR-21, miR-191 and miR-192 compared to those from healthy people. +other 30604696 hsa-mir-139 Prostatitis 5p, showed similar expression patterns. +other 30604696 hsa-mir-150 Prostatitis 5p, showed similar expression patterns. +other 30604696 hsa-mir-146b Prostatitis 5p, showed similar expression patterns. +other 30604587 hsa-mir-103 Cardiomegaly TRPV3 protein, cardiac hypertrophy marker proteins (BNP and beta-MHC) and autophagy associated proteins (Beclin-1 and LC3-II) were up-regulated, as well as, miR-103 expression and autophagy associated proteins (p62) were down-regulated in cardiac hypertrophy models in vivo and in vitro respectively. +genetics_GWAS 30604411 hsa-mir-124 Pancreatic Carcinoma CONCLUSIONS Our study demonstrated that EphA2 rescued by miR-124 downregulation conferred the erlotinib resistance of PC cell Capan-1 with K-RAS mutation. +other 30604399 hsa-mir-199a Keloid miRNA-199a may be one key factor in the cell cycle checkpoint signal pathway of keloid-derived fibroblasts. +other 30604382 hsa-mir-361 Intellectual Disability 3p.2) act as critical regulators of X-linked and autosomal ID genes in a fully connected network. +other 30604382 hsa-mir-221 Intellectual Disability 3p.2) act as critical regulators of X-linked and autosomal ID genes in a fully connected network. +other 30604382 hsa-mir-222 Intellectual Disability 3p.2) act as critical regulators of X-linked and autosomal ID genes in a fully connected network. +other 30604382 hsa-mir-504 Intellectual Disability 3p.2) act as critical regulators of X-linked and autosomal ID genes in a fully connected network. +other 30604382 hsa-mir-362 Intellectual Disability 3p.2) act as critical regulators of X-linked and autosomal ID genes in a fully connected network. +other 30604369 hsa-mir-143 Colorectal Neoplasms 3p, and miR-1290 were up-regulated compared with primary CRC. +other 30604369 hsa-mir-518f Colorectal Neoplasms 3p, and miR-1290 were up-regulated compared with primary CRC. +other 30604369 hsa-mir-130b Colorectal Neoplasms 3p, and miR-1290 were up-regulated compared with primary CRC. +other 30604369 hsa-mir-1290 Colorectal Neoplasms 3p, and miR-1290 were up-regulated compared with primary CRC. +other 30604369 hsa-mir-21 Colorectal Neoplasms 3p, and miR-1290 were up-regulated compared with primary CRC. +other 30604369 hsa-mir-122 Colorectal Neoplasms 3p, and miR-1290 were up-regulated compared with primary CRC. +other 30603140 hsa-mir-520c gastric adenocarcinoma Our results do not verify miR-520c previously established oncogenic role in IGA. +circulation_biomarker_diagnosis_up 30603135 hsa-mir-320e Esophageal Neoplasms Validation by qRT-PCR confirmed that serum miR-320e levels were significantly decreased in the BE group compared to the SE (PC, rs57095329 A>G and the expression of miRNA-146a in ethnic South Asian children with acute lymphoblastic leukemia (ALL). +transcription factor target 30576425 hsa-mir-338 Esophageal Squamous Cell Carcinoma 5p may play an antioncogenic role in ESCC via repressing FERMT2. +other 30576282 hsa-mir-16 Stomach Neoplasms Taken together, these results suggest that circNF1 acts as a novel oncogenic circRNA in GC by functioning as a miR-16 sponge. +genetics_overexpression_promote 30576245 hsa-mir-370 Endometriosis Overexpression of miR +transcription factor target 30576241 hsa-mir-451a Diabetic Retinopathy In conclusion, miR-451a/ATF2 plays a vital role in the regulation of proliferation and migration in RPE cells through regulation of mitochondrial function, which may provide new perspectives for developing effective therapies for PDR. +lncRNA target 30576233 hsa-mir-338 Alzheimer Disease 5p in AD is regulated through the NF-kappaB signaling pathway. +lncRNA target 30576232 hsa-mir-135b Stomach Neoplasms Poor expression of microRNA-135b results in the inhibition of cisplatin resistance and proliferation and induces the apoptosis of gastric cancer cells through MST1-mediated MAPK signaling pathway. +lncRNA target 30575983 hsa-mir-204 Pneumonia, Mycoplasma 5p axis could be a potential therapeutic target for the treatment of PE. +lncRNA target 30575977 hsa-let-7c Pulpitis In rat pulpitis models, the injection of let-7c-5p agomir restored the osteogenic differentiation potential of dental pulp cells and inhibited HMGA2/PI3K/Akt signalling. +other 30575941 hsa-mir-488 Osteoporosis RESULTS: In the present study, we found that the expression of miR-488 in patients with osteoporosis was significantly lower than that of healthy controls. +transcription factor target 30575929 hsa-mir-203 Hypertension, Pulmonary OBJECTIVE: The aim of this study was to investigate whether hypoxia in vivo can induce hypoxic pulmonary hypertension by inhibiting the activation of FGF2 by miR-203. +other 30575923 hsa-mir-143 Cartilage Diseases 3p) in cartilage injury, and to investigate the possible underlying mechanism. +genetics_overexpression_promote 30575921 hsa-mir-410 Precursor Cell Lymphoblastic Leukemia-Lymphoma The overexpression of miR-410 accelerated the proliferation and colony formation ability of ALL cells, whereas remarkably decreased cell apoptosis rate. +genetics_overexpression_promote 30575920 hsa-mir-152 Leukemia, Myelogenous, Chronic, BCR-ABL Positive 3p was up-regulated or down-regulated in the CML cell line (K562) by transfection with overexpressed lentivirus LV5-miR +genetics_overexpression_promote 30575919 hsa-mir-128 Glioma Further rescue experiments suggested that NEK2 overexpression partially reversed the effect of miR-128 on the apoptosis of glioma cells. +lncRNA target 30575917 hsa-mir-4282 Breast Neoplasms CONCLUSIONS: miR-4282 inhibited the occurrence and development of breast cancer by regulating Myc, which made it a new target for clinical diagnosis and treatment of breast cancer. +other 30575908 hsa-mir-1 Rectal Neoplasms CONCLUSIONS: miR-31 is increasingly expressed in rectal cancer. +lncRNA target 30575907 hsa-mir-138 Colorectal Neoplasms CONCLUSIONS: We provided important evidence that PODXL, targeted by miR-138, acted as a tumor promoter in CRC by suppressing CRC cells proliferation and metastasis, which may provide a novel potential target for diagnostic and therapeutic applications in CRC. +circulation_biomarker_prognosis_ns 30575906 hsa-mir-199a Colorectal Neoplasms CONCLUSIONS: Reduced serum miR-199a was associated with poor prognosis in CRC and it might be useful as a marker for diagnosis and prognosis in CRC. +circulation_biomarker_prognosis_ns 30575905 hsa-mir-24 Colorectal Neoplasms CONCLUSIONS: We showed that the plasma ratio of miR-21/24 is a potentially powerful tool for detecting CRC and predicting prognosis. +circulation_biomarker_prognosis_ns 30575905 hsa-mir-21 Colorectal Neoplasms CONCLUSIONS: We showed that the plasma ratio of miR-21/24 is a potentially powerful tool for detecting CRC and predicting prognosis. +genetics_knock down_promote 30575904 hsa-mir-210 Pancreatic Carcinoma CONCLUSIONS: MiR-210 knockdown promotes cell proliferation by upregulating E2F3 expression, thereby promoting the progression of pancreatic cancer. +lncRNA target 30575901 hsa-mir-103 Urinary Bladder Neoplasms Thus, inhibiting miR-103/107 may be a therapeutic approach for bladder cancer treatment. +lncRNA target 30575901 hsa-mir-107 Urinary Bladder Neoplasms Thus, inhibiting miR-103/107 may be a therapeutic approach for bladder cancer treatment. +lncRNA target 30575898 hsa-mir-620 Uterine Cervical Neoplasms Furthermore, the results revealed that circSMARCA5 suppressed proliferation and invasion by miR-620 in CC. CONCLUSIONS: We suggested that circSMARCA5/miR-620 regulatory axis is involved in the development of CC and may serve as a potential therapy target. +genetics_overexpression_promote 30575897 hsa-mir-1294 Osteosarcoma Overexpression of miR-1294 suppresses OS cell proliferation and invasion in vitro. +circulation_biomarker_diagnosis_ns 30575896 hsa-mir-195 Osteoarthritis In addition, in vitro regulatory roles of lncRNA-TUG1 and miR-195 in osteoarthritis were verified by transfection of lncRNA-TUG1 and miR-195 plasmids. +epigenetics 30575719 hsa-mir-150 Leukemia, Myelomonocytic, Chronic Here, we identify a down-regulation of hsa-miR-150 through methylation of a lineage-specific promoter in CMML monocytes. +other 30575333 hsa-mir-186 Pulmonary Disease, Chronic Obstructive However, the role of microRNA-186 (miR-186) in relation to HIF in COPD is unknown. CONCLUSIONS: These data suggested that miR-186 contributes to the pathogenesis of COPD and that miRNA-186 may also affect the HIF-1alpha-dependent lung structure maintenance program. +genetics_knock down_suppress 30575330 hsa-mir-193a Colorectal Neoplasms The impact of knockdown of both NEAT1 and its predicted downstream miR-193a-3p in CRC cells was examined here to delve into their interactions and mechanisms. Generally, lncRNA NEAT1/hsa-miR-193a-3p/KRAS axis was substantiated in CRC cells and could provide novel insight into both diagnostic and therapeutic advancement in CRC. +other 30575326 hsa-mir-525 Asthenozoospermia DISCUSSION AND CONCLUSION: The elevated expression of SEMG1 and reduced expression of miR3p are associated with AZS and male infertility. +other 30575081 hsa-mir-222 Glioblastoma This study aimed to investigate the possible role of miR-222/GAS5 axis on DNA damage and cytotoxic effects induced by TMZ in glioblastoma cells (T98G). +transcription factor target 30574422 hsa-mir-1292 Aicardi-Goutieres syndrome 5 miR-1292 might serve as a novel therapeutic target for the prevention and treatment of osteoporosis or other diseases related to bone metabolism and aging. +transcription factor target 30574422 hsa-mir-1292 Bone Diseases, Metabolic miR-1292 might serve as a novel therapeutic target for the prevention and treatment of osteoporosis or other diseases related to bone metabolism and aging. +transcription factor target 30574422 hsa-mir-1292 Bone Diseases miR-1292 might serve as a novel therapeutic target for the prevention and treatment of osteoporosis or other diseases related to bone metabolism and aging. +transcription factor target 30574422 hsa-mir-1292 Osteoporosis miR-1292 might serve as a novel therapeutic target for the prevention and treatment of osteoporosis or other diseases related to bone metabolism and aging. +lncRNA target 30574162 hsa-mir-101 Esophageal Squamous Cell Carcinoma Conclusion: The lncRNA FAM201A, which mediated the radiosensitivity of ESCC by regulating ATM and mTOR expression via miR-101 in the present study, may be a potential biomarker for predicting radiosensitivity and patient prognosis, and may be a therapeutic target for enhancing cancer radiosensitivity in ESCC. +lncRNA target 30574141 hsa-mir-1 Rheumatic Diseases Here we show that the microRNA- (miR-) 31 is upregulated in murine Th1 cells with a history of repeated reactivation and in memory Th cells isolated from the synovial fluid of patients with rheumatic joint disease. +genetics_overexpression_promote 30574019 hsa-mir-133b Osteosarcoma Both the Ras/MAPK and PI3K/Akt intracellular signaling cascades were inhibited in response to overexpressing miRNA-133b or knocking down FGFR1 in OS cells. +genetics_overexpression_promote 30573973 hsa-mir-93 Carcinoma, Hepatocellular In addition, hsa-miR-93 was upregulated in SNHG16-overexpressed HCC cells to examine its effect on SNHG16-mediated cancer cell functional regulation in HCC. CONCLUSION: Our data demonstrate that SNHG16 plays a critical role in HCC development via functionally sponging hsa-miR-93. +transcription factor target 30573163 hsa-mir-210 Lung Neoplasms Next, transfection of miR-210 mimics in lung cancer cells induced significant increase in cell proliferation, and transfection of miR-210 inhibitors lead to inhibited cell proliferation. +genetics_overexpression_promote 30572959 hsa-mir-133a Stomach Neoplasms RESULTS: We demonstrated that microRNA-133a-3p overexpression could block the activation of autophagy to ruin the abnormal glutaminolysis and further inhibit the growth and metastasis of gastric cancer cells. +circulation_biomarker_diagnosis_up 30572760 hsa-mir-133a Hypertension Furthermore, miR-133a was elevated in the plasma of hypertensive human subjects, compared with normotensive patients. +circulation_biomarker_diagnosis_up 30572760 hsa-mir-133a Hypotension Interestingly, the abundance of miR-133a was decreased in TA tissue and increased in the plasma in both models of hypertension compared with a normotensive control group. Furthermore, miR-133a was elevated in the plasma of hypertensive human subjects, compared with normotensive patients. +genetics_knock down_promote 30572760 hsa-mir-133a Giant Cell Arteritis Mechanisms contributing to the loss of miR-133a abundance were further investigated in TA fibroblasts. +other 30572760 hsa-mir-133a Aortic Aneurysm, Thoracic Background Reduced miR-133a was previously found to be associated with thoracic aortic ( TA ) dilation, as seen in aneurysm disease. +other 30572760 hsa-mir-133a Aneurysm Background Reduced miR-133a was previously found to be associated with thoracic aortic ( TA ) dilation, as seen in aneurysm disease. +other 30572504 hsa-mir-145 Carcinoma, Hepatocellular Furthermore, multivariate analysis using the Cox proportional hazards model for all variables showed that miR-145 expression was an independent prognostic factor for overall survival (P = .033).Our results indicate that low expression of miR-145 is an independent poor prognostic factor for patients with HCC. +other 30571914 hsa-mir-34a Multiple Myeloma These TAT/miRNA-loaded nanogels delivered and released miR-34a with high efficiency into OPM-2 multiple myeloma cells that are known as transfection-resistant. +other 30571142 hsa-mir-34a osteogenesis imperfecta type 1 We observed down-regulation of miR-34a, and up-regulation of Notch1 and Hey1 in retinas from OIR rats. +genetics_overexpression_promote 30570877 hsa-mir-194 Urinary Bladder Neoplasms Treatment of BC cells with E2F3 siRNA had the same effect as did overexpression of miR +lncRNA target 30570871 hsa-mir-182 Esophageal Squamous Cell Carcinoma CONCLUSIONS: miR-182 could suppress ESCC cell proliferation and metastasis via regulating YWHAG, which might provide a new target for ESCC diagnosis and therapy. +transcription factor target 30570867 hsa-mir-24 Carcinoma, Non-Small-Cell Lung The aim of this study was to investigate whether MiR-24 can regulate cell proliferation of NSCLC by targeting ZNF367. +lncRNA target 30570857 hsa-mir-150 Colorectal Neoplasms CONCLUSIONS Circ-ZNF609 regulates Gli1 expression via microRNA-150, thus affecting the migration of colorectal cancer. +lncRNA target 30570852 hsa-mir-372 Breast Neoplasms 3p is upregulated in breast carcinoma tissues, which promotes the viability and invasion of breast carcinoma cells through the Wnt pathway. +lncRNA target 30570849 hsa-mir-1 Breast Neoplasms CONCLUSIONS: It appears that the use of miR-31 is highly efficient than miR-143 in the inhibition of invasion and metastasis in breast cancer. +lncRNA target 30570849 hsa-mir-143 Breast Neoplasms CONCLUSIONS: It appears that the use of miR-31 is highly efficient than miR-143 in the inhibition of invasion and metastasis in breast cancer. +genetics_overexpression_promote 30570350 hsa-mir-106a Breast Neoplasms Additionally, miR-106a overexpression significantly decreased breast cancer cell apoptosis and sensitivity to cisplatin. +other 30570107 hsa-mir-663a Pancreatic Carcinoma Furthermore, miR663a5p with 9 circRNAs, 8 lncRNAs and 46 genes could form a prospective ceRNA network associated with autophagy in pancreatic cancer cells. +other 30570073 hsa-mir-126 Diabetes Mellitus OBJECTIVE: The present study sought to explore the effect of garlic and voluntary exercise, alone or together, on miR-126 and miR-210 expressions and cardiac angiogenesis in rats with type 1 diabetes. +other 30570073 hsa-mir-210 Diabetes Mellitus Moreover, treating diabetic rats with garlic and voluntary exercise combined had an additional effect on the expressions of miR-126 and miR-210 (p < 0.001). +other 30569973 hsa-mir-141 Nasopharyngeal Carcinoma In conclusion, miR-141 was up-regulated in the biopsy samples and thus may be a potential biomarker for NPC in the Vietnamese population. +transcription factor target 30569880 hsa-mir-597 Nasopharyngeal Carcinoma 3sigma acts as a tumor suppressor gene and its expression in NPC cell lines is negatively correlated with miR-597. +circulation_biomarker_diagnosis_ns 30569636 hsa-mir-122 Non-alcoholic Fatty Liver Disease Moreover, the levels of circulating and hepatic miR +circulation_biomarker_diagnosis_ns 30569636 hsa-mir-122 Obesity Moreover, the levels of circulating and hepatic miR +circulation_biomarker_diagnosis_ns 30569636 hsa-mir-192 Obesity Moreover, the levels of circulating and hepatic miR +circulation_biomarker_diagnosis_ns 30569636 hsa-mir-192 Non-alcoholic Fatty Liver Disease Moreover, the levels of circulating and hepatic miR +genetics_GWAS 30569605 hsa-mir-21 Colorectal Neoplasms These data suggest that the miR-21 binding site SNP rs6504593 in the IGF2BP1 3'-UTR may alter IGF2BP1 expression and contribute to colorectal cancer risk. +other 30569515 hsa-mir-150 Uterine Cervical Neoplasms In conclusion, our current research reveals the important role of hsa_circ_0000263/miR5p/MDM4/p53 regulatory network in cervical cancer and provides a new insight into the pathogenesis of cervical cancer. +other 30569514 hsa-mir-107 Pancreatic Carcinoma CONCLUSION The study revealed a regulatory network of UCA1-miRITGA2 and validated UCA1 and ITGA2 as potential prognostic factors for PaC. +genetics_overexpression_promote 30569513 hsa-mir-21 Stomach Neoplasms Effects of LINC-PINT overexpression on cellular behaviors of gastric cancer cells were attenuated by miR-21 overexpression. +lncRNA target 30569478 hsa-mir-149 Carcinoma, Non-Small-Cell Lung Therefore, we concluded that PCAT-1 may promote the development of NSCLC through the miR +lncRNA target 30569180 hsa-mir-224 Astrocytoma Therefore, miR2243p could be a novel target against hypoxiainduced autophagy in glioblastoma and astrocytoma. +lncRNA target 30569180 hsa-mir-224 Glioblastoma Therefore, miR2243p could be a novel target against hypoxiainduced autophagy in glioblastoma and astrocytoma. +genetics_overexpression_promote 30569179 hsa-mir-200a Carcinoma, Non-Small-Cell Lung Immunohistochemical staining and western blot analyses demonstrated that HGF was upregulated and associated with miR200a downregulation in nonsmall cell lung cancer (NSCLC) samples compared with normal lung tissues. miR200a overexpression induced HGF downregulation, decreased NSCLC cell migration and invasion, promoted apoptosis, and decreased cell survival in A549 and H1299 cells in response to ionizing radiation. +lncRNA target 30569167 hsa-mir-495 Lung Neoplasms In addition, miR495 suppressed the proliferation of lung cancer cells by directly targeting HMGA2. +other 30569158 hsa-mir-486 Liver Neoplasms Several miRNAs including miR4865p (miR486) were found to be significantly downregulated in liver cancer tissues. miR486 was significantly downregulated in tumor spheres and liver cancer samples. +lncRNA target 30569153 hsa-mir-18a Nasopharyngeal Carcinoma In summary, CASC2 regulates NPC malignancy through modulation of RBBP8 via sponging miR18a5p. +transcription factor target 30569149 hsa-mir-21 Esophageal Squamous Cell Carcinoma In conclusion, miR21 regulated cell proliferation, migration, invasion and tumor growth of ESCC by directly targeting RASA1, which may have been achieved via regulation of Snail and vimentin. +genetics_overexpression_suppress 30569129 hsa-mir-206 Esophageal Squamous Cell Carcinoma Notably, cMet overexpression inhibited the effects of miR206 on the proliferation and apoptosis of ESCC cells. +other 30569125 hsa-mir-210 Pre-Eclampsia mRNA expression of miR210 was significantly increased in PE. In placenta from women with PE, compared with normal pregnant women, mRNA expression of Foxp3 was significantly decreased, and expression of miR210 was significantly increased. +transcription factor target 30569124 hsa-mir-134 Stomach Neoplasms In conclusion, the present study demonstrated that miR134 may suppress the proliferation, invasion and EMT of SGC7901 cells by targeting FoxM1, and may serve a protective role in the process of H. +lncRNA target 30569120 hsa-mir-204 Breast Neoplasms In conclusion, miR2045p may serve a suppressor role in the oncogenesis and advancement of BC, and miR2045p may have crucial functions in BC by targeting RACGAP1. +genetics_overexpression_promote 30569116 hsa-mir-542 Osteosarcoma Taken together, these results have demonstrated that miR5423p was overexpressed in OS. +transcription factor target 30569106 hsa-mir-150 Nasopharyngeal Carcinoma Using a CD44 3'untranslated region luciferase reporter assay, miR150 was confirmed to be a novel CD44targeting miRNA, which could directly target CD44 and subsequently regulate the migration of NPC cells. +lncRNA target 30569100 hsa-mir-107 Carcinoma, Endometrioid In conclusion, our results highlighted that miR1075p is a novel prognostic factor that targets ERalpha to promote tumor proliferation and invasion of EC. +genetics_knock down_promote 30569091 hsa-mir-766 Carcinoma, Pancreatic Ductal Furthermore, ETS1 knockdown simulated the inhibitory effects of the overexpression of miR766 on PDAC cells, whereas the effects of miR766 restoration on the PDAC cells were reversed by overexpressing ETS1. +lncRNA target 30569090 hsa-mir-15a arthrogryposis, renal dysfunction, and cholestasis 1 In conclusion, miR15a3p may suppress cell proliferation and migration, and induce cell apoptosis in lens epithelial cells through inhibiting the expression of BCL2 and MCL1, which contributes to the onset of ARCs. +lncRNA target 30568710 hsa-let-7d Stomach Neoplasms The aim of the study was to develop a conjugate consisting of aptNCL (as targeted delivery of therapeutic agent) and miRNA let-7d (as a tumor suppressor) using two different linking methods and also to evaluate the potential effect of the conjugates on the proliferation of gastric cancer (MKN-45) cell line compared to negative control cell line of human dermal fibroblast (HDF). +genetics_GWAS 30568542 hsa-mir-149 Coronary Artery Disease METHODS: Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were performed to identify the genotypes of the miR-149 SNP rs2292832 in 421 unrelated subjects (272 with CAD and 149 controls). +other 30568508 hsa-mir-509-2 Cervial Cancer 2, and hsa-miR-526b may be potential diagnostic biomarkers for early-stage CESC with LNM, and serve as prognostic predictors for patients with CESC. +other 30568508 hsa-mir-508 Cervial Cancer 2, and hsa-miR-526b may be potential diagnostic biomarkers for early-stage CESC with LNM, and serve as prognostic predictors for patients with CESC. +other 30568508 hsa-mir-508 Uterine Cervical Neoplasms 2, and hsa-miR-526b may be potential diagnostic biomarkers for early-stage CESC with LNM, and serve as prognostic predictors for patients with CESC. +other 30568508 hsa-mir-509-2 Uterine Cervical Neoplasms 2, and hsa-miR-526b may be potential diagnostic biomarkers for early-stage CESC with LNM, and serve as prognostic predictors for patients with CESC. +other 30568508 hsa-mir-526b Uterine Cervical Neoplasms 2, and hsa-miR-526b may be potential diagnostic biomarkers for early-stage CESC with LNM, and serve as prognostic predictors for patients with CESC. +other 30568508 hsa-mir-526b Cervial Cancer 2, and hsa-miR-526b may be potential diagnostic biomarkers for early-stage CESC with LNM, and serve as prognostic predictors for patients with CESC. +lncRNA target 30568467 hsa-mir-21 Carcinoma, Non-Small-Cell Lung 5p promoted the expressions of MMP-9 and vimentin proteins as well as inhibited the expression of E-cadherin protein, which is associated with an elevated SMAD7 protein expression and enhanced the invasion/migration ability of NSCLC cells. +circulation_biomarker_diagnosis_ns 30568292 hsa-mir-155 Breast Neoplasms Plasma miR-21, miR-155, miR-10b, and Let-7a as the potential biomarkers for the monitoring of breast cancer patients. The plasma expression of the miR-21, miR-155, and miR-10b was significantly increased and the Let-7a plasma expression decreased in the breast cancer patients compromised to the control ones. +circulation_biomarker_diagnosis_ns 30568292 hsa-mir-21 Breast Neoplasms Plasma miR-21, miR-155, miR-10b, and Let-7a as the potential biomarkers for the monitoring of breast cancer patients. The plasma expression of the miR-21, miR-155, and miR-10b was significantly increased and the Let-7a plasma expression decreased in the breast cancer patients compromised to the control ones. +circulation_biomarker_diagnosis_ns 30568292 hsa-mir-10b Breast Neoplasms Plasma miR-21, miR-155, miR-10b, and Let-7a as the potential biomarkers for the monitoring of breast cancer patients. The plasma expression of the miR-21, miR-155, and miR-10b was significantly increased and the Let-7a plasma expression decreased in the breast cancer patients compromised to the control ones. +circulation_biomarker_diagnosis_ns 30568292 hsa-let-7a Breast Neoplasms Plasma miR-21, miR-155, miR-10b, and Let-7a as the potential biomarkers for the monitoring of breast cancer patients. The plasma expression of the miR-21, miR-155, and miR-10b was significantly increased and the Let-7a plasma expression decreased in the breast cancer patients compromised to the control ones. +other 30568281 hsa-mir-185 Attention Deficit Disorder with Hyperactivity 5p, being highly predictive for diagnostic status in an independent dataset of 44 ADHD cases and 46 controls. +other 30568281 hsa-mir-26b Attention Deficit Disorder with Hyperactivity 5p, being highly predictive for diagnostic status in an independent dataset of 44 ADHD cases and 46 controls. +circulation_biomarker_diagnosis_ns 30568162 hsa-mir-25 Colorectal Neoplasms 3p is involved in pre-metastatic niche formation and may be used as a blood-based biomarker for CRC metastasis. +other 30567426 hsa-mir-21 Breast Neoplasms As a result, dual analysis of MUC1 and miR-21 at low-nanomolar concentrations in vitro, as well as in situ simultaneous imaging of the biomarkers within MCF-7 breast cancer cells, was achieved. +other 30567426 hsa-mir-21 Familial Multiple Coagulation Factor Deficiency I As a result, dual analysis of MUC1 and miR-21 at low-nanomolar concentrations in vitro, as well as in situ simultaneous imaging of the biomarkers within MCF-7 breast cancer cells, was achieved. +lncRNA target 30566393 hsa-mir-150 Prostatic Neoplasms The aim of the current study was to investigate the ability of microRNA-150 (miR-150) targeting transient receptor potential melastatin 4 (TRPM4) to mediate epithelial-mesenchymal transition (EMT), invasion, and metastasis through the beta-catenin signaling pathway in PCa. +lncRNA target 30565858 hsa-mir-9 Prostatic Neoplasms 5p and its targeting gene QKI-5. +genetics_overexpression_promote 30565744 hsa-mir-802 Uterine Cervical Neoplasms Rescue experiments revealed that overexpression of SRSF9 partially reversed the inhibition effect of miR-802 in cervical cancer cells. +other 30565701 hsa-mir-374b Coronary Artery Disease In human coronary artery disease, disease severity is associated with decreased MAPK7 expression levels and increased miR-374b expression levels. +lncRNA target 30565701 hsa-mir-374b Endometrial Hyperplasia Endothelial-mesenchymal transition occurs in intimal hyperplasia and early lesion formation and is governed in part by microRNA-374b-induced silencing of MAPK7 signaling. Thus, our data suggest that the TGF-miR-374b-MAPK7 axis plays a key role in the induction of endothelial-mesenchymal transition during intimal hyperplasia and early lesion formation and might pose an interesting target for antiatherosclerosis therapy. +lncRNA target 30565694 hsa-mir-22 Carcinoma, Non-Small-Cell Lung Mechanistically, we found that circFGFR3 promoted NSCLC cell invasion and proliferation via competitively combining with miR3p to facilitate the galectin-1 (Gal-1), p-AKT, and p-ERK1/2 expressions. +other 30565690 hsa-mir-145 Hypospadias In conclusion, SOX9, which was regulated by both miR-145 and miR-145/MAPK signaling, could be involved in the pathogenesis of hypospadias. +other 30565678 hsa-mir-347 Myocardial Reperfusion Injury In accordance with this, the myocardial infarction area was decreased with the upregulated miR-347 and downregulated DTNA. +other 30565618 hsa-mir-215 Selenium Deficiency Our findings support the potential of applying miRNAs during the process of cardiogenesis and indicate that miR5p could be a novel candidate for treatment of cardiac hypoevolutism. +circulation_biomarker_prognosis_up 30565568 hsa-mir-210 Fetal Hypoxia OBJECTIVE: To explore whether miR-210 expression can be used as a diagnostic and prognostic marker in acute fetal hypoxia. RESULTS: We confirmed that miR-210 is significantly more upregulated in fetal blood with acute hypoxia when compared to maternal blood (P Conclusions: Our study confirmed miR-210 upregulation in the blood of pregnant women with acute fetal hypoxia at the time of labour compared to pregnant women without acute fetal hypoxia. +genetics_overexpression_promote 30565566 hsa-mir-769 Colorectal Neoplasms Finally, overexpression of HEY1 reversed the effects of miR-769 on cell proliferation and invasion in CRC. +genetics_knock down_suppress 30565392 hsa-mir-206 Osteosarcoma miR-206 inhibition partially rescued the inhibitory effects on OS cells induced by ROR knockdown. In conclusion, these results suggested that ROR function as an oncogene in OS by sponging miR-206 and might be a potential therapeutic target for patients with OS. +lncRNA target 30565391 hsa-let-7a Tuberculosis Moreover, circRNA_101128 expression in TB samples was negatively correlated with the level of its possible target let-7a and bioinformatics analysis showed that circRNA_101128 was potentially involved in MAPK and P13K-Akt pathway possibly via modulation of let-7a. Taken together, our results indicated that some dysregulated circRNAs were potential biomarkers for the diagnosis of TB and circRNA_101128-let-7a interplay may play considerable role in PBMCs response to Mtb infection. +transcription factor target 30565389 hsa-mir-148a Hepatitis C CONCLUSIONS: MiR-148a-3p suppressed the proliferation of HCC cells infected with HCV through targeting c-Jun mRNA. +transcription factor target 30565389 hsa-mir-148a Carcinoma, Hepatocellular CONCLUSIONS: MiR-148a-3p suppressed the proliferation of HCC cells infected with HCV through targeting c-Jun mRNA. +other 30565074 hsa-mir-424 Obesity In addition, higher levels of miR-27 and miR-424 were correlated with higher fat depot measurements in nonobese women. +other 30565043 hsa-mir-21 Stomach Neoplasms MiR-21 Participates in the PD-1/PD-L1 Pathway-Mediated Imbalance of Th17/Treg Cells in Patients After Gastric Cancer Resection. However, it remains largely unknown whether miR-21 is regulated by PD-1 and influences CD4+ T-cell lineage choice after gastric cancer resection. +other 30564636 hsa-mir-543 Glioblastoma 5p, and miR-543) as the most stable for classifying glioblastoma. +other 30564636 hsa-mir-486 Glioblastoma 5p, and miR-543) as the most stable for classifying glioblastoma. +other 30564636 hsa-mir-485 Glioblastoma 5p, and miR-543) as the most stable for classifying glioblastoma. +other 30564636 hsa-mir-28 Glioblastoma 5p, and miR-543) as the most stable for classifying glioblastoma. +other 30563768 hsa-mir-204 Colorectal Neoplasms In conclusion, we found that lncBRM was highly expressed in CRC and sponged miR3p to modulate the expression of TPT1. +other 30563542 hsa-mir-10b Central Nervous System Diseases Higher expression of miR-10b-5p in the neoplastic group is consistent with previous reports in human medicine where aberrant expression of miR-10b is associated with various neoplastic diseases of the CNS. +genetics_overexpression_promote 30563429 hsa-mir-211 Hypoxia-Ischemia, Brain RESULTS: Compared with control group, lncRNA MIAT and GDNF were downregulated in striatal tissues of neonatal rats in HI group and oxygen glucose deprivation (OGD)-induced ischemic injury of Neuro2A cells, whereas miR-211 was up-regulated in striatal tissues of HI group and OGD-induced ischemic injury of Neuro2A cells. CONCLUSION: MIAT overexpression reduced apoptosis of Neuro2A cells through miR-211/GDNF, which relieved HI injury of neonatal rats. +other 30563325 hsa-mir-155 Colonic Neoplasms Finally, the biosensor was successfully applied to the detection of microRNA-155 extracted from the colon-cancer cell line DLD1, demonstrating its potential application in the sensitive detection of biological samples in the early diagnosis of diseases. +lncRNA target 30563239 hsa-let-7e Osteoarthritis Visfatin and resistin significantly reduced viability, induced apoptosis, increased miR-34a, miR-155, miR-181a, and miR-let7e, and reduced miR-140 and miR-146a gene expression in OA chondrocytes. +lncRNA target 30563239 hsa-mir-146a Osteoarthritis Visfatin and resistin significantly reduced viability, induced apoptosis, increased miR-34a, miR-155, miR-181a, and miR-let7e, and reduced miR-140 and miR-146a gene expression in OA chondrocytes. +lncRNA target 30563239 hsa-mir-155 Osteoarthritis Visfatin and resistin significantly reduced viability, induced apoptosis, increased miR-34a, miR-155, miR-181a, and miR-let7e, and reduced miR-140 and miR-146a gene expression in OA chondrocytes. +lncRNA target 30563239 hsa-mir-34a Osteoarthritis Visfatin and resistin significantly reduced viability, induced apoptosis, increased miR-34a, miR-155, miR-181a, and miR-let7e, and reduced miR-140 and miR-146a gene expression in OA chondrocytes. +lncRNA target 30563239 hsa-mir-140 Osteoarthritis Visfatin and resistin significantly reduced viability, induced apoptosis, increased miR-34a, miR-155, miR-181a, and miR-let7e, and reduced miR-140 and miR-146a gene expression in OA chondrocytes. +lncRNA target 30563239 hsa-mir-181a Osteoarthritis Visfatin and resistin significantly reduced viability, induced apoptosis, increased miR-34a, miR-155, miR-181a, and miR-let7e, and reduced miR-140 and miR-146a gene expression in OA chondrocytes. +exosome 30562989 hsa-mir-16 Prostatic Neoplasms The most diagnostically significant miRNAs pairs were miRmiR-26b.5p and miR-375.3p-miR-26b.5p in the urine supernatant fraction that discriminated the group of healthy patients and PCa patients, as well as miR-31.5p-miR-16.5p, miR-31.5p-miR-200b, miR-31.5p-miR-30e.3p and miR-31.5p-miR-660.5p in the fraction extracellular vesicles that were different between healthy men and benign prostate hyperplasia patients. +exosome 30562989 hsa-mir-107 Prostatic Neoplasms The most diagnostically significant miRNAs pairs were miRmiR-26b.5p and miR-375.3p-miR-26b.5p in the urine supernatant fraction that discriminated the group of healthy patients and PCa patients, as well as miR-31.5p-miR-16.5p, miR-31.5p-miR-200b, miR-31.5p-miR-30e.3p and miR-31.5p-miR-660.5p in the fraction extracellular vesicles that were different between healthy men and benign prostate hyperplasia patients. +exosome 30562989 hsa-mir-1 Prostatic Neoplasms The most diagnostically significant miRNAs pairs were miRmiR-26b.5p and miR-375.3p-miR-26b.5p in the urine supernatant fraction that discriminated the group of healthy patients and PCa patients, as well as miR-31.5p-miR-16.5p, miR-31.5p-miR-200b, miR-31.5p-miR-30e.3p and miR-31.5p-miR-660.5p in the fraction extracellular vesicles that were different between healthy men and benign prostate hyperplasia patients. +exosome 30562989 hsa-mir-375 Prostatic Neoplasms The most diagnostically significant miRNAs pairs were miRmiR-26b.5p and miR-375.3p-miR-26b.5p in the urine supernatant fraction that discriminated the group of healthy patients and PCa patients, as well as miR-31.5p-miR-16.5p, miR-31.5p-miR-200b, miR-31.5p-miR-30e.3p and miR-31.5p-miR-660.5p in the fraction extracellular vesicles that were different between healthy men and benign prostate hyperplasia patients. +exosome 30562989 hsa-mir-26b Prostatic Neoplasms The most diagnostically significant miRNAs pairs were miRmiR-26b.5p and miR-375.3p-miR-26b.5p in the urine supernatant fraction that discriminated the group of healthy patients and PCa patients, as well as miR-31.5p-miR-16.5p, miR-31.5p-miR-200b, miR-31.5p-miR-30e.3p and miR-31.5p-miR-660.5p in the fraction extracellular vesicles that were different between healthy men and benign prostate hyperplasia patients. +other 30562760 hsa-mir-148a Fibrosis The high level of HOTTIP downregulates miR-148a, thus to increase the level of TGFBR1 and TGFBR2 and contribute to liver fibrosis. +lncRNA target 30562741 hsa-mir-494 Hemangioma Furthermore, MEG3 was verified to act as a sponge of miR-494 in HAs cells, and miR-494 counteracted MEG3-caused anti-proliferative effects by regulating PTEN/PI3K/AKT pathway, and exhibited the negative correlation with MEG3 and PTEN expression in proliferating phase HAs. CONCLUSION Our findings suggested that lncRNA MEG3 inhibited HAs tumorigenesis by sponging miR-494 and regulating PTEN/PI3K/AKT pathway. +other 30562735 hsa-mir-486 Parkinson Disease MiR3p mimics can decrease the level of SIRT2 and reduce a-synuclein (alpha-syn)-induced aggregation and toxicity, which may contribute to the progression of PD. +circulation_biomarker_diagnosis_ns 30561106 hsa-mir-451a Carcinoma, Pancreatic Ductal METHODS: Exosomal miR-4525, miR-451a and miR-21 expressions were assessed using PVB and peripheral blood (PB) collected from 55 PDAC patients during curative pancreatectomy. CONCLUSIONS: miR-4525, miR-451a and miR-21 in PVB are potential biomarkers identifying patients at high-risk for recurrence and poor survival in resected PDAC patients. +circulation_biomarker_diagnosis_ns 30561106 hsa-mir-4525 Carcinoma, Pancreatic Ductal METHODS: Exosomal miR-4525, miR-451a and miR-21 expressions were assessed using PVB and peripheral blood (PB) collected from 55 PDAC patients during curative pancreatectomy. CONCLUSIONS: miR-4525, miR-451a and miR-21 in PVB are potential biomarkers identifying patients at high-risk for recurrence and poor survival in resected PDAC patients. +circulation_biomarker_diagnosis_ns 30561106 hsa-mir-21 Carcinoma, Pancreatic Ductal METHODS: Exosomal miR-4525, miR-451a and miR-21 expressions were assessed using PVB and peripheral blood (PB) collected from 55 PDAC patients during curative pancreatectomy. CONCLUSIONS: miR-4525, miR-451a and miR-21 in PVB are potential biomarkers identifying patients at high-risk for recurrence and poor survival in resected PDAC patients. +lncRNA target 30560585 hsa-mir-99a Urinary Bladder Neoplasms These suggested that miR-99a-5p/mTOR axis might be a therapeutic target for bladder cancer. +genetics_GWAS 30560371 hsa-mir-196a-2 Instent Restenosis CONCLUSIONS: Our data suggests that the T allele of the miRNA-196a2 C/T (rs11614913) polymorphism is associated with the risk of developing CAD, but no association with restenosis was observed. +genetics_GWAS 30560371 hsa-mir-196a-2 Coronary Artery Disease CONCLUSIONS: Our data suggests that the T allele of the miRNA-196a2 C/T (rs11614913) polymorphism is associated with the risk of developing CAD, but no association with restenosis was observed. +genetics_overexpression_promote 30560327 hsa-mir-214 Glycogen Storage Disease Type VI CONCLUSION: miR-214 overexpression reduces hepatocyte apoptosis after HIR injury through negatively regulating TRAF1/ASK1/JNK pathway. +lncRNA target 30560317 hsa-mir-29b Heart Failure Taken together, our data suggest that miR-29b-3p plays an important role in the progression of HF through targeting SPARC and regulating TGFbeta1/Smad3 pathway. +other 30560088 hsa-mir-210 Carcinoma, Hepatocellular Conclusion: hsa-miR-210 might promote vascular invasion of HCC cells and could be used as a prognostic biomarker. +lncRNA target 30559931 hsa-mir-140 Lung Neoplasms In conclusion, two forms of miR-140 both suppress the malignant properties of lung cancer cells but through distinct and multiple mechanisms. +transcription factor target 30559849 hsa-mir-150 Leukemia, Myeloid, Acute CONCLUSION: Our results suggest that miR-150 functions as a tumour suppressor and gatekeeper in inhibiting cell transformation and that its downregulation is required for leukemogenesis. +genetics_overexpression_suppress 30559405 hsa-mir-4516 Glioblastoma Overexpression of miR-4516 significantly enhanced cell proliferation and invasion of GBM cells both in vitro and in vivo. +other 30559069 hsa-mir-148a Heart Failure Here, we demonstrate that miR-148a expression changes dynamically in distinct subtypes of heart failure: while it is elevated in concentric hypertrophy, it decreased in dilated cardiomyopathy. These findings show the ability of miR-148a to prevent the transition of pressure-overload induced concentric hypertrophic remodeling toward eccentric hypertrophy and dilated cardiomyopathy and provide evidence for the existence of separate molecular programs inducing distinct forms of myocardial remodeling. +circulation_biomarker_diagnosis_up 30558790 hsa-mir-181a Non-alcoholic Fatty Liver Disease MiR-181a expression was significantly upregulated in the serum of NAFLD patients and PA-induced hepatocytes. +other 30558527 hsa-mir-473 Nager acrofacial dysostosis Furthermore, the accumulation patterns of sequence variants of selected conserved miRNAs showed a very distinct pattern related to AMF colonization - one variant of miR473-5p specifically accumulated in AMF-inoculated plants. +other 30558527 hsa-mir-403a Nager acrofacial dysostosis Six conserved miRNAs were present in all conditions and accumulated differentially depending on treatment and genotype; five (miR6153, miR403a-3p, miR7122a, miR167-5p and miR482d, but not miR399a-3p) showed the highest accumulation in AMF inoculated EV plants compared to inoculated irCCaMK plants. Also abundances of miR403a-3p, miR171a-3p and one of the sequence variants of miR172a-3p increased in AMF-inoculated EV compared to inoculated irCCaMK plants and to non-inoculated EV plants, while miR399a-3p was most strongly enriched in AMF inoculated irCCaMK plants grown in competition with EV. +other 30558527 hsa-mir-171a Nager acrofacial dysostosis Also abundances of miR403a-3p, miR171a-3p and one of the sequence variants of miR172a-3p increased in AMF-inoculated EV compared to inoculated irCCaMK plants and to non-inoculated EV plants, while miR399a-3p was most strongly enriched in AMF inoculated irCCaMK plants grown in competition with EV. +other 30558527 hsa-mir-172 Nager acrofacial dysostosis Also abundances of miR403a-3p, miR171a-3p and one of the sequence variants of miR172a-3p increased in AMF-inoculated EV compared to inoculated irCCaMK plants and to non-inoculated EV plants, while miR399a-3p was most strongly enriched in AMF inoculated irCCaMK plants grown in competition with EV. +other 30558527 hsa-mir-482d Nager acrofacial dysostosis Six conserved miRNAs were present in all conditions and accumulated differentially depending on treatment and genotype; five (miR6153, miR403a-3p, miR7122a, miR167-5p and miR482d, but not miR399a-3p) showed the highest accumulation in AMF inoculated EV plants compared to inoculated irCCaMK plants. +other 30558527 hsa-mir-99 Nager acrofacial dysostosis Six conserved miRNAs were present in all conditions and accumulated differentially depending on treatment and genotype; five (miR6153, miR403a-3p, miR7122a, miR167-5p and miR482d, but not miR399a-3p) showed the highest accumulation in AMF inoculated EV plants compared to inoculated irCCaMK plants. Also abundances of miR403a-3p, miR171a-3p and one of the sequence variants of miR172a-3p increased in AMF-inoculated EV compared to inoculated irCCaMK plants and to non-inoculated EV plants, while miR399a-3p was most strongly enriched in AMF inoculated irCCaMK plants grown in competition with EV. +other 30558527 hsa-mir-167 Nager acrofacial dysostosis Six conserved miRNAs were present in all conditions and accumulated differentially depending on treatment and genotype; five (miR6153, miR403a-3p, miR7122a, miR167-5p and miR482d, but not miR399a-3p) showed the highest accumulation in AMF inoculated EV plants compared to inoculated irCCaMK plants. +other 30558527 hsa-mir-7122a Nager acrofacial dysostosis Six conserved miRNAs were present in all conditions and accumulated differentially depending on treatment and genotype; five (miR6153, miR403a-3p, miR7122a, miR167-5p and miR482d, but not miR399a-3p) showed the highest accumulation in AMF inoculated EV plants compared to inoculated irCCaMK plants. +other 30558527 hsa-mir-6153 Nager acrofacial dysostosis Six conserved miRNAs were present in all conditions and accumulated differentially depending on treatment and genotype; five (miR6153, miR403a-3p, miR7122a, miR167-5p and miR482d, but not miR399a-3p) showed the highest accumulation in AMF inoculated EV plants compared to inoculated irCCaMK plants. +other 30558527 hsa-mir-99a Nager acrofacial dysostosis Six conserved miRNAs were present in all conditions and accumulated differentially depending on treatment and genotype; five (miR6153, miR403a-3p, miR7122a, miR167-5p and miR482d, but not miR399a-3p) showed the highest accumulation in AMF inoculated EV plants compared to inoculated irCCaMK plants. Also abundances of miR403a-3p, miR171a-3p and one of the sequence variants of miR172a-3p increased in AMF-inoculated EV compared to inoculated irCCaMK plants and to non-inoculated EV plants, while miR399a-3p was most strongly enriched in AMF inoculated irCCaMK plants grown in competition with EV. +other 30558527 hsa-mir-172a Nager acrofacial dysostosis Also abundances of miR403a-3p, miR171a-3p and one of the sequence variants of miR172a-3p increased in AMF-inoculated EV compared to inoculated irCCaMK plants and to non-inoculated EV plants, while miR399a-3p was most strongly enriched in AMF inoculated irCCaMK plants grown in competition with EV. +other 30558527 hsa-mir-482 Nager acrofacial dysostosis Six conserved miRNAs were present in all conditions and accumulated differentially depending on treatment and genotype; five (miR6153, miR403a-3p, miR7122a, miR167-5p and miR482d, but not miR399a-3p) showed the highest accumulation in AMF inoculated EV plants compared to inoculated irCCaMK plants. +other 30558403 hsa-mir-1202 Varicose Veins CONCLUSIONS: The results suggested that the lncRNA-GAS5, miRNA-661, miRNA-1202 and MMP9 are involved in varicose disease. +other 30558403 hsa-mir-661 Varicose Veins CONCLUSIONS: The results suggested that the lncRNA-GAS5, miRNA-661, miRNA-1202 and MMP9 are involved in varicose disease. +lncRNA target 30557872 hsa-mir-205 Adenocarcinoma of Lung The expression levels, survival analysis, and receiver operating characteristic curve of the dysregulated miRNAs based on The Cancer Genome Atlas database for lung adenocarcinoma showed that hsa-mir-192, hsa-mir-1293, hsa-mir-194, hsa-mir-561, hsa-mir-205, hsa-mir-30a, and hsa-mir-30c were related to lung cancer, whereas only hsa-mir-1293 and hsa-mir-561 were not involved in drug resistance. +lncRNA target 30557872 hsa-mir-1293 Adenocarcinoma of Lung The expression levels, survival analysis, and receiver operating characteristic curve of the dysregulated miRNAs based on The Cancer Genome Atlas database for lung adenocarcinoma showed that hsa-mir-192, hsa-mir-1293, hsa-mir-194, hsa-mir-561, hsa-mir-205, hsa-mir-30a, and hsa-mir-30c were related to lung cancer, whereas only hsa-mir-1293 and hsa-mir-561 were not involved in drug resistance. +lncRNA target 30557872 hsa-mir-194 Adenocarcinoma of Lung The expression levels, survival analysis, and receiver operating characteristic curve of the dysregulated miRNAs based on The Cancer Genome Atlas database for lung adenocarcinoma showed that hsa-mir-192, hsa-mir-1293, hsa-mir-194, hsa-mir-561, hsa-mir-205, hsa-mir-30a, and hsa-mir-30c were related to lung cancer, whereas only hsa-mir-1293 and hsa-mir-561 were not involved in drug resistance. +lncRNA target 30557872 hsa-mir-1293 Lung Neoplasms The expression levels, survival analysis, and receiver operating characteristic curve of the dysregulated miRNAs based on The Cancer Genome Atlas database for lung adenocarcinoma showed that hsa-mir-192, hsa-mir-1293, hsa-mir-194, hsa-mir-561, hsa-mir-205, hsa-mir-30a, and hsa-mir-30c were related to lung cancer, whereas only hsa-mir-1293 and hsa-mir-561 were not involved in drug resistance. +lncRNA target 30557872 hsa-mir-194 Lung Neoplasms The expression levels, survival analysis, and receiver operating characteristic curve of the dysregulated miRNAs based on The Cancer Genome Atlas database for lung adenocarcinoma showed that hsa-mir-192, hsa-mir-1293, hsa-mir-194, hsa-mir-561, hsa-mir-205, hsa-mir-30a, and hsa-mir-30c were related to lung cancer, whereas only hsa-mir-1293 and hsa-mir-561 were not involved in drug resistance. +lncRNA target 30557872 hsa-mir-561 Adenocarcinoma of Lung The expression levels, survival analysis, and receiver operating characteristic curve of the dysregulated miRNAs based on The Cancer Genome Atlas database for lung adenocarcinoma showed that hsa-mir-192, hsa-mir-1293, hsa-mir-194, hsa-mir-561, hsa-mir-205, hsa-mir-30a, and hsa-mir-30c were related to lung cancer, whereas only hsa-mir-1293 and hsa-mir-561 were not involved in drug resistance. +lncRNA target 30557872 hsa-mir-561 Lung Neoplasms The expression levels, survival analysis, and receiver operating characteristic curve of the dysregulated miRNAs based on The Cancer Genome Atlas database for lung adenocarcinoma showed that hsa-mir-192, hsa-mir-1293, hsa-mir-194, hsa-mir-561, hsa-mir-205, hsa-mir-30a, and hsa-mir-30c were related to lung cancer, whereas only hsa-mir-1293 and hsa-mir-561 were not involved in drug resistance. +lncRNA target 30557872 hsa-mir-205 Lung Neoplasms The expression levels, survival analysis, and receiver operating characteristic curve of the dysregulated miRNAs based on The Cancer Genome Atlas database for lung adenocarcinoma showed that hsa-mir-192, hsa-mir-1293, hsa-mir-194, hsa-mir-561, hsa-mir-205, hsa-mir-30a, and hsa-mir-30c were related to lung cancer, whereas only hsa-mir-1293 and hsa-mir-561 were not involved in drug resistance. +genetics_overexpression_promote 30557834 hsa-mir-542 Carcinoma, Ovarian Epithelial CDK14 overexpression reversed the suppressive effects of miR +lncRNA target 30557546 hsa-mir-217 Stomach Neoplasms Hotair promoted GC development by promoting GCP5 expression via sponging miR-217. +other 30557454 hsa-mir-106b Parkinsonian Disorders The classifier that best distinguished MSA and PD consisted of two microRNAs: miR3p and miR-106b-5p (area under the curve = 0.73). +other 30557454 hsa-mir-9 Parkinsonian Disorders The classifier that best distinguished MSA and PD consisted of two microRNAs: miR3p and miR-106b-5p (area under the curve = 0.73). +virus_miRNA 30557400 ebv-mir-BART1 Nasopharyngeal Carcinoma EBV-miR-BART1-5P activates AMPK/mTOR/HIF1 pathway via a PTEN independent manner to promote glycolysis and angiogenesis in nasopharyngeal carcinoma. +genetics_overexpression_promote 30557355 hsa-mir-607 Carcinoma, Non-Small-Cell Lung We found that overexpression of miR +other 30557328 hsa-mir-455 Gastrointestinal Stromal Tumors We found high positive correlations between expression of H19 and known GIST related oncogene ETV1, and between H19 and miR3p. +other 30557194 hsa-mir-4254 Erythroblastosis, Fetal 5p) exhibited significant effects (false discovery rate P value < 0.05) across pre- or postrun and RH/NRH groups. +other 30557194 hsa-mir-1273 Rh Deficiency Syndrome 5p) exhibited significant effects (false discovery rate P value < 0.05) across pre- or postrun and RH/NRH groups. +other 30557194 hsa-mir-4254 Rh Deficiency Syndrome 5p) exhibited significant effects (false discovery rate P value < 0.05) across pre- or postrun and RH/NRH groups. +lncRNA target 30557194 hsa-mir-1273 Erythroblastosis, Fetal Mitogen-activated protein kinase (MAPK11), an endocannabinoid target of miR +other 30557194 hsa-mir-4676 Erythroblastosis, Fetal 5p) exhibited significant effects (false discovery rate P value < 0.05) across pre- or postrun and RH/NRH groups. +other 30557194 hsa-mir-4676 Rh Deficiency Syndrome 5p) exhibited significant effects (false discovery rate P value < 0.05) across pre- or postrun and RH/NRH groups. +exosome 30556910 hsa-let-7b Encephalitis, Japanese Here, we identified let-7a and let-7b (let-7a/b) as one of the essential miRNAs over-expressed upon Japanese Encephalitis virus (JEV) infection and released in the culture supernatant of the JEV-infected microglial cells through extracellular vesicles. +exosome 30556910 hsa-let-7a Encephalitis, Japanese Here, we identified let-7a and let-7b (let-7a/b) as one of the essential miRNAs over-expressed upon Japanese Encephalitis virus (JEV) infection and released in the culture supernatant of the JEV-infected microglial cells through extracellular vesicles. +other 30556887 hsa-mir-130a Heart Failure CONCLUSIONS: miRNA-130a could improve cardiac function of heart failure rat by down-regulating TNF-alpha. +other 30556885 hsa-mir-218 Lung Injury CONCLUSIONS: The expression of microRNA-218 markedly decreased in lung tissue of ALI rats, while the expression of inflammatory cytokines showed a remarkable increase, which might be related to the activation of RUNX2 and NF-kappaB. +other 30556885 hsa-mir-218 Sepsis CONCLUSIONS: The expression of microRNA-218 markedly decreased in lung tissue of ALI rats, while the expression of inflammatory cytokines showed a remarkable increase, which might be related to the activation of RUNX2 and NF-kappaB. +other 30556884 hsa-mir-132 Hepatitis B, Chronic OBJECTIVE: To explore the expressions of miR-132 in patients with chronic hepatitis B, posthepatitic cirrhosis and hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), and to investigate its possible mechanism affecting the function of the body. +lncRNA target 30556883 hsa-mir-212 Leukemia, Myeloid, Acute 5p/FZD5 was likely to become a new therapeutic target for AML. +other 30556881 hsa-mir-1231 Glioma CONCLUSIONS Our study, for the first time, provides evidence that evaluating miR-1231 in glioma may have prognostic and predictive value in the clinical management of glioma. +lncRNA target 30556880 hsa-mir-650 Glioma CONCLUSIONS: MiR-650 was lowly expressed in glioma tissues, which could promote cell proliferation through up-regulating the expression of FAM83F. +genetics_overexpression_promote 30556879 hsa-mir-196 Breast Neoplasms Overexpression of miR-3196 could repress the proliferation and induce the apoptosis of breast cancer cells via targeting the 3'UTR of ERBB3. +genetics_overexpression_promote 30556878 hsa-mir-1179 Breast Neoplasms Gain-of-function assay indicated that the overexpression of miR-1179 significantly suppressed BC cells proliferation, migration and invasion. +circulation_biomarker_diagnosis_ns 30556877 hsa-mir-21 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: MiR-19 and miR-21 are highly expressed in peripheral blood of patients with undifferentiated lung cancer; miR-19 and miR-21 are expected to be used as diagnostic markers for undifferentiated lung cancer. +other 30556876 hsa-let-7 Lung Neoplasms CONCLUSIONS: Low expression of let-7 is closely related to the poor prognosis of lung cancer patients. +genetics_overexpression_promote 30556875 hsa-mir-143 Lung Neoplasms The LncRNA UCA1 was also found to upregulate the expression of miR-143, and overexpression of miR-143 could also suppress the proliferation, migration, and invasion of the SK-MES-1 lung cancer cells. +transcription factor target 30556874 hsa-mir-615 Adenocarcinoma of Lung It promoted proliferation and metastasis but inhibited cell apoptosis of LAC cells via sponging miR5p to promote AKT1 expression. +lncRNA target 30556873 hsa-mir-761 Carcinoma, Non-Small-Cell Lung CONCLUSIONS We found that FENDRR was down-expressed in NSCLC and the over-expression of FENDRR inhibited the malignant phenotypes of NSCLC cell by binding to miR-761 competitively. +lncRNA target 30556872 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS Low expression of MEG3 can promote the proliferation and migration of OSCC cells through targeted binding to miR-21. +lncRNA target 30556870 hsa-mir-490 Esophageal Squamous Cell Carcinoma CONCLUSIONS: We discovered the inhibitory effect of miR +genetics_knock down_promote 30556861 hsa-mir-1266 Colorectal Neoplasms Knockdown of microRNA-1266 promoted proliferation of CRC cells. +other 30556850 hsa-mir-429 Ovarian Neoplasms CONCLUSIONS: GIHCG is highly expressed in OC, which promotes OC development by stimulating cell cycle progression and cell proliferation by regulating microRNA-429. +lncRNA target 30556849 hsa-mir-10a Carcinoma, Ovarian Epithelial CONCLUSIONS: Circ-ITCH suppresses cells proliferation and promotes cells apoptosis via sponging miR-10a in EOC cells. +lncRNA target 30556842 hsa-mir-487b Rhinitis, Allergic ST2 axis may be a potential therapeutic target for the treatment of allergic rhinitis. +lncRNA target 30556591 hsa-mir-338 Angelman Syndrome 3p promoted ox-LDL-induced HUVEC cell injury by targeting BAMBI and activating the TGF-beta/Smad pathway, which may provide a novel and promising therapeutic target for AS. +lncRNA target 30556306 hsa-mir-548p Carcinoma, Hepatocellular Elevated expression of circular RNA circ_0008450 predicts dismal prognosis in hepatocellular carcinoma and regulates cell proliferation, apoptosis, and invasion via sponging miR-548p. +other 30556190 hsa-mir-205 Poisoning Quantitative real-time polymerase chain reaction showed that miR-205 expression was significantly higher in early atretic follicles and progressively atretic follicles than in healthy follicles. +other 30556190 hsa-mir-205 Anovulation These results indicate that miR-205 might play an important role in ovarian follicular development and provide new insights into follicular atresia. +other 30556161 hsa-mir-216a Carcinoma, Hepatocellular A1BG-AS1 positively regulated the levels of phosphatase and tensin homolog and SMAD family member 7, which were reduced by miR-216a-5p in HCC cells. +genetics_knock down_promote 30556160 hsa-mir-219 Alzheimer Disease Our findings indicate that the upregulation of TTBK1 and GSK-3beta mediated by the loss of miR +lncRNA target 30556158 hsa-mir-202 Varicose Veins In conclusion, miR-202 affects VSMC phenotypic transition by targeting PGC-1alpha expression, providing a novel target for varicose vein therapy. +lncRNA target 30555870 hsa-mir-132 Anxiety Disorders "The data presented here are related to our research article entitled ""miR-132/212 is induced by stress and its dysregulation triggers anxiety-related behavior"" (Aten et al., 2018)." +lncRNA target 30555745 hsa-mir-125a Squamous Cell Carcinoma of Head and Neck Thus, it could be concluded that ANRIL promoted the progression of HNSCC via miR-125a-3p/FGFR1/MAPK signaling, which might provide a new target for the diagnosis and treatment of HNSCC. +genetics_knock down_promote 30555741 hsa-mir-744 Glioblastoma Moreover, NOB1 knockdown exhibited similar inhibitory effects as miR-744 overexpression in GBM cells. +transcription factor target 30555597 hsa-mir-34a Triple Negative Breast Neoplasms Specifically, we developed LbL-NS to deliver the tumor suppressor miR-34a into triple-negative breast cancer (TNBC) cells, and demonstrate that these constructs can safely and effectively regulate the expression of SIRT1 and Bcl-2, two known targets of miR-34a, to decrease cell proliferation. CONCLUSION: LbL-NS can efficiently deliver miR-34a to TNBC cells to suppress cancer cell growth, warranting their further investigation as tools for miRNA replacement therapy. +transcription factor target 30555597 hsa-mir-34a Behcet Syndrome Specifically, we developed LbL-NS to deliver the tumor suppressor miR-34a into triple-negative breast cancer (TNBC) cells, and demonstrate that these constructs can safely and effectively regulate the expression of SIRT1 and Bcl-2, two known targets of miR-34a, to decrease cell proliferation. +exosome 30555555 hsa-mir-21 Pulmonary Disease, Chronic Obstructive Conclusion: We demonstrate that CS triggers the modification of exosome components and identify miR-21 derived from bronchial epithelial cells as a mediator of myofibroblast differentiation through the pVHL/HIF-1alpha signaling pathway, which has potential value for diagnosis and treatment of COPD. +lncRNA target 30555521 hsa-mir-34a Fatty Liver CONCLUSION: Our results suggested that GP modulated the gut microbiota and suppressed hepatic miR-34a, which was associated with the amelioration of hepatic steatosis. +lncRNA target 30555259 hsa-mir-424 Colorectal Neoplasms We demonstrated that miR-424 functioned as a tumor suppressor by suppressing colorectal cancer growth in vitro and in vivo and enhancing apoptosis. +lncRNA target 30555237 hsa-mir-346 Osteosarcoma Inhibiting miR-346 led to a significant upregulation of FBXL19-AS1, suggesting FBXL19-AS1 was negatively regulated by miR-346, which was further confirmed by the inverse correlation between FBXL19-AS1 and miR-346 expression in OS patient specimens. +genetics_GWAS 30555079 hsa-mir-520f Breast Neoplasms However, no study has been conducted to investigate the association of the mir-520f rs75598818G>A in BC. A contribution of the mir-520f rs75598818 polymorphism to BC had been unexplored before. +other 30554863 hsa-mir-155 Prostatic Neoplasms We measured levels of miR-21/146a/155 expression by quantitative real-time PCR (qRT-PCR), comparative DeltaDeltaCt method, in fifteen patients with localized prostate cancer, treated with three-dimensional conformal radiotherapy (3DCRT). CONCLUSION: miR-21/146a/155 might be useful potential factors of radiosensitivity and acute genitourinary radiotoxicity in prostate cancer patients. +other 30554863 hsa-mir-21 Prostatic Neoplasms We measured levels of miR-21/146a/155 expression by quantitative real-time PCR (qRT-PCR), comparative DeltaDeltaCt method, in fifteen patients with localized prostate cancer, treated with three-dimensional conformal radiotherapy (3DCRT). CONCLUSION: miR-21/146a/155 might be useful potential factors of radiosensitivity and acute genitourinary radiotoxicity in prostate cancer patients. +other 30554863 hsa-mir-146a Prostatic Neoplasms We measured levels of miR-21/146a/155 expression by quantitative real-time PCR (qRT-PCR), comparative DeltaDeltaCt method, in fifteen patients with localized prostate cancer, treated with three-dimensional conformal radiotherapy (3DCRT). CONCLUSION: miR-21/146a/155 might be useful potential factors of radiosensitivity and acute genitourinary radiotoxicity in prostate cancer patients. +genetics_overexpression_promote 30554587 hsa-mir-29a Pancreatitis Moreover, caspase 3 levels in AP cell model were increased than vector control after overexpression of miR-29a, and caspase-3 levels were reduced than vector control after suppressing of miR-29a expression. +other 30554584 hsa-mir-107 Colorectal Neoplasms Results The expression of miR-107 was significantly up-regulated in both colorectal cancer tissues and cells. +genetics_overexpression_promote 30554584 hsa-mir-107 Colonic Neoplasms Conclusion Overexpression of miR-107 in both colon cancer tissues and cells promotes the proliferation and tumor formation potential of HT29 cells via up-regulating cyclin D1 expression. +lncRNA target 30554489 hsa-mir-1915 Stomach Neoplasms CONCLUSION: MiR-1915 exerted tumor-suppressive effects on cellular proliferation, invasion, and migration of HP-infected GC cells via targeting RAGE, which provided an innovative target candidate for treatment of HP-infected GC. +genetics_overexpression_promote 30554487 hsa-mir-506 Carcinoma, Hepatocellular Mechanistically, overexpressing STAT3 greatly reversed miR +lncRNA target 30554121 hsa-mir-338 Carcinoma, Non-Small-Cell Lung 3p inhibition partially reversed the CRNDE depletion-mediated inhibitory effect on cell proliferation, colony formation, migration and invasion in NSCLC cells. +other 30554090 hsa-mir-155 Glioma This meta-analysis aims to evaluate the prognostic value of miR-155 in the survival of patients with gliomas. The pooled HR of elevated miR-155 for OS in patients with gliomas was 1.40 (95%CI [1.19-1.63], P < 0.001) (I-squared = 52.4%, P = 0.032) suggesting that miR-155 might be a promising biomarker for the prognosis of gliomas in future clinical applications. +genetics_knock down_promote 30553455 hsa-mir-506 Lymphoma, Mantle-Cell Rescue experiments suggested that the restoration of B7H3 expression in MCL cells reversed the inhibition of proliferation and invasion induced by miRNA-506 overexpression. +lncRNA target 30553447 hsa-mir-204 Thyroid Cancer, Papillary Thus, LINC00514 promoted CDC23 expression via restraining miR3p activity, leading to PTC progression. +lncRNA target 30553445 hsa-mir-185 Glioma Taken together, our data firstly demonstrated that CREB1-induced FOXD2-AS1 contributed to glioma progression by upregulating AKT1 via competitively binding to miR-185, providing a novel strategy for targeting FOXD2-AS1 as a potential biomarker and a therapeutic target in glioma patients. +circulation_biomarker_diagnosis_up 30553134 hsa-mir-212 Carcinoma, Pancreatic Ductal These nanoparticles could deliver miR-212 into PDAC cells specifically and efficiently which also showed good stability in RNase and serum. +lncRNA target 30552989 hsa-mir-10b Pre-Eclampsia In summary, the WDR86-AS1/miR-10b-3p/LITAF network is probably involved in PE pathogenesis. +other 30552897 hsa-mir-193a Amyotrophic Lateral Sclerosis MiR-15a-5p and miR-193a-5p were identified for their diagnostic potential of ALS and association with disability progression, respectively. +other 30552897 hsa-mir-15a Amyotrophic Lateral Sclerosis MiR-15a-5p and miR-193a-5p were identified for their diagnostic potential of ALS and association with disability progression, respectively. +lncRNA target 30552827 hsa-mir-212 Ischemic Stroke Our study suggests that miR-212 promotes recovery function and vascular regeneration of EPCs through negative regulation of the Notch signaling pathway via downregulating expression of MMP9, thus provides a clinical theoretical basis for ischemic stroke therapy. +genetics_overexpression_promote 30552711 hsa-mir-186 Breast Neoplasms Overexpression of miR-186 inhibited BC cells proliferation, migration, and epithelial-mesenchymal transition process; while suppression of miR-186 exhibited an opposite effects on BC cells. +genetics_GWAS 30552691 hsa-mir-34b Thyroid Cancer, Papillary In conclusion, the present study shows that let7a-2 rs1143770 and pri-mir-34b/c rs4938723 polymorphisms could be susceptible factors for PTC and some clinical features. +other 30552681 hsa-mir-24 Myocardial Reperfusion Injury 5p and miR-499a-5p). +other 30552681 hsa-let-7c Myocardial Reperfusion Injury 5p and miR-499a-5p). +other 30552681 hsa-mir-126 Myocardial Reperfusion Injury 5p and miR-499a-5p). +other 30552681 hsa-mir-20a Myocardial Reperfusion Injury 5p and miR-499a-5p). +other 30552681 hsa-mir-15b Myocardial Reperfusion Injury 5p and miR-499a-5p). +other 30552681 hsa-mir-214 Myocardial Reperfusion Injury 5p and miR-499a-5p). +other 30552681 hsa-mir-195 Myocardial Reperfusion Injury 5p and miR-499a-5p). +circulation_biomarker_diagnosis_ns 30552617 hsa-mir-15a Lymphoma, Large B-Cell, Diffuse The circulating microRNA-15a (miRNA-15a) and microRNA +lncRNA target 30552617 hsa-mir-16-1 Lymphoma, Large B-Cell, Diffuse 1 might be suggested to behave as a tumor suppressor in DLBCL in our study. +genetics_GWAS 30552364 hsa-mir-4513 Adenocarcinoma of Lung Our findings suggest that miR-608 and miR-4513 SNPs are independent candidate biomarkers to predict lung adenocarcinoma patients' survival after EGFR-TKIs treatment. +genetics_GWAS 30552364 hsa-mir-608 Adenocarcinoma of Lung Our findings suggest that miR-608 and miR-4513 SNPs are independent candidate biomarkers to predict lung adenocarcinoma patients' survival after EGFR-TKIs treatment. +other 30552326 hsa-mir-122 Carcinoma, Hepatocellular Disrupting expression of miR-122 can re-activate embryo-expressed adult-silenced genes, ultimately leading to the development of hepatocellular carcinoma (HCC). +circulation_biomarker_diagnosis_ns 30552311 hsa-mir-375 Diabetes Mellitus In human serum exosomes, hsa-miR3p was elevated in new-onset diabetes patients. +other 30552145 hsa-mir-379 Neurodevelopmental Disorders Thus, the miR379-410 cluster acts a natural brake for sociability, and interfering with specific members of this cluster could represent a therapeutic strategy for the treatment of social deficits in neurodevelopmental disorders. +other 30552145 hsa-mir-379 Social Communication Disorder Thus, the miR379-410 cluster acts a natural brake for sociability, and interfering with specific members of this cluster could represent a therapeutic strategy for the treatment of social deficits in neurodevelopmental disorders. +circulation_biomarker_diagnosis_ns 30552111 hsa-mir-20b Diabetes Mellitus, Type 2 To validate the role of these differentially abundant miRNAs on glucose metabolism, we transfected miR-20b-5p, a highly abundant exoRNA in patients with type 2 diabetes, into primary human skeletal muscle cells. In conclusion, exosome-derived extracellular miR-20b-5p is a circulating biomarker associated with type 2 diabetes that plays an intracellular role in modulating insulin-stimulated glucose metabolism via AKT signaling. +exosome 30551896 hsa-mir-23a Nephritis, Interstitial Taken together, our studies demonstrate that the HIF-1alpha-dependent release of miRNA-23a-enriched exosomes from hypoxic tubular epithelial cells activates macrophages to promote tubulointerstitial inflammation. +other 30551880 hsa-mir-1205 Glioma Collectively, circ_0034642/miR-1205/BATF3 pathway may play an important role in glioma. +genetics_overexpression_suppress 30551873 hsa-mir-221 Urinary Bladder Neoplasms In addition, we also revealed that circMTO1 was able to sponge miR-221 and overexpression of circMTO1 negatively regulated the E-cadherin/N-cadherin pathway to inhibit bladder cancer cells' EMT by competing for miR-221. +transcription factor target 30551723 hsa-mir-221 Medulloblastoma These results uncovered the tumor suppressive role of miR +lncRNA target 30551553 hsa-mir-532 Carcinoma, Hepatocellular 3p, which is frequently up-regulated in HCC, contributes to HCC cells mobility and proliferation through targeting PTPRT. +transcription factor target 30551550 hsa-mir-145 Facial Nerve Diseases Besides, miR-145/Bnip3/mitophagy axis may be considered as a potential target for the treatment of facial neuritis in clinical practice. +other 30551536 hsa-mir-4666a Heart Defects, Congenital 3p) capable of distinguishing CHDs from controls (area under the ROC curve (AUC), 0.920; p < 0.0001). +other 30551536 hsa-mir-1275 Heart Defects, Congenital 3p) capable of distinguishing CHDs from controls (area under the ROC curve (AUC), 0.920; p < 0.0001). +other 30551536 hsa-mir-142 Heart Defects, Congenital 3p) capable of distinguishing CHDs from controls (area under the ROC curve (AUC), 0.920; p < 0.0001). +genetics_GWAS 30551532 hsa-mir-100 Osteosarcoma In summary, our study indicated that ELK1-induced upregulation of MIR100HG promoted OS progression by epigenetically silencing LATS1 and LATS2 and inactivating Hippo pathway. +lncRNA target 30551528 hsa-mir-384 Esophageal Squamous Cell Carcinoma Upregulation of miR-384 or LIMK1 inhibition was determined to block the LIMK1/cofilin signaling pathway, repress cell proliferation, invasion, cell cycle, LNM and tumor growth, while promote cell apoptosis in ESCC. +circulation_biomarker_diagnosis_down 30551500 hsa-mir-152 Atherosclerosis miR-152 is down-regulated in the serum samples of AS patients and inhibits the migration of human umbilical vein endothelial cell, suggesting that miR-152 exerts a role in the atherogenesis. +lncRNA target 30551495 hsa-mir-1270 Thyroid Cancer, Papillary CONCLUSION: Hsa-miR-1270 downregulation may suppress human PTC cell development both in vitro and in vivo. +lncRNA target 30551492 hsa-let-7g Osteosarcoma In conclusion, hsa-let-7 g is highly expressed in osteosarcoma tissues, and high expression of hsa-let-7 g can promote the occurrence of osteosarcoma by down-regulating HOXB1 and activating NF-kB pathway. +other 30551491 hsa-mir-6785 Stomach Neoplasms 5p and miR-642a-3p and increasing FOXO4 expression. +other 30551491 hsa-mir-642a Stomach Neoplasms 5p and miR-642a-3p and increasing FOXO4 expression. +lncRNA target 30551480 hsa-mir-494 Esophageal Squamous Cell Carcinoma Moreover, miR-494 was down-regulated in esophageal cancer tissues and cells. CONCLUSIONS: The data presented in this study revealed that XIST abnormal expression may play an oncogenic role in the development of esophageal cancer via miR-494/CDK6 axis through JAK2/STAT3 signal pathway. +transcription factor target 30551476 hsa-mir-181b Glioma In conclusion, our findings indicate that upregulation of miR-181b-5p targets Bcl-2 directly and may function as an important modifier to sensitize glioma cells to TMZ. +transcription factor target 30551470 hsa-mir-139 Prostatic Neoplasms 5p functioned as a tumor suppressor in prostate cancer cells by regulation of SOX5, and it might be a promising target for prostate cancer patients. +lncRNA target 30551459 hsa-mir-613 Colonic Neoplasms The results indicated that lncRNA-HULC was markedly increased in colon cancer cell lines and accelerated colon cancer cell growth by targeting miR-613. Additionally, the modulation of rhotekin (RTKN) by miR-613 was necessary in HULC-induced colon cancer cell proliferation and metastasis. +lncRNA target 30551451 hsa-mir-128 Thyroid Neoplasms Thus, our study illustrated that miR-128 might be a tumor suppressor microRNA that played an essential role in thyroid carcinoma progression. +lncRNA target 30551450 hsa-mir-449a Gastrointestinal Stromal Tumors Suppression of miR-449a reversed the Nef-induced GIST-T1 cell proliferation and migration inhibition, as well as cell apoptosis. +genetics_knock down_promote 30551440 hsa-mir-144 Carcinoma, Non-Small-Cell Lung CONCLUSION Knockdown of DLX6-AS1 inhibited cell proliferation, migration, invasion and promoted apoptosis by downregulating PRR11 expression and upregulating miR-144 in NSCLC. +genetics_knock down_promote 30551440 hsa-mir-144 Lung Neoplasms CONCLUSION Knockdown of DLX6-AS1 inhibited cell proliferation, migration, invasion and promoted apoptosis by downregulating PRR11 expression and upregulating miR-144 in NSCLC. +genetics_GWAS 30551433 hsa-mir-34a Leukemia, Myeloid, Acute In summary, TUG1 knockdown overcame ADR resistance of AML by epigenetically enhancing miR-34a expression, providing a novel therapeutic target for AML. +lncRNA target 30551428 hsa-mir-150 Diabetic Nephropathies In conclusion, these results indicate that miR-150 protects against hypoxia-induced pulmonary vascular remodeling, fibrosis, abnormal proliferation of PASMCs and PAECs, which suggests miR-150 as a promising therapeutic target for PH. +lncRNA target 30551428 hsa-mir-150 Diabetic Retinopathy In conclusion, these results indicate that miR-150 protects against hypoxia-induced pulmonary vascular remodeling, fibrosis, abnormal proliferation of PASMCs and PAECs, which suggests miR-150 as a promising therapeutic target for PH. +lncRNA target 30551417 hsa-mir-520d Carcinoma, Hepatocellular In summary, our study has identified a novel signaling pathway through which miR-520d-3p exerts its anticarcinogenic roles and suggested that the MIAT/miR-520d-3p/EPHA2 may be a new target for HCC therapy. +lncRNA target 30551410 hsa-mir-125b Osteoarthritis CONCLUSIONS: Our results indicate that HOTAIRM1-1 is downregulated in OA cartilages, and its downregulation may inhibit MSCs viability, induce apoptosis and suppress differentiation via regulating miR-125b/BMPR2 axis. +genetics_overexpression_suppress 30551391 hsa-mir-1 Prostatic Neoplasms Subsequently, we found that overexpression of miR-1 could inhibit viability and proliferation of PC cells functionally. +transcription factor target 30551379 hsa-mir-92b Nephrotic Syndrome These finding suggest that ZWT may reduce renal edema in Adriamycin-induced nephropathy via regulating AQP2 and miR-92b. +genetics_knock down_promote 30551364 hsa-mir-23c Carcinoma, Hepatocellular Interestingly, erbb2 interacting protein (ERBB2IP), a known target of miR-23c, was positively regulated by KTN1-AS1 and its restoration reversed KTN1-AS1 knockdown attenuated HCC cell growth. +transcription factor target 30551361 hsa-mir-217 Femur Head Necrosis These findings suggest that miR-217 promotes cell proliferation and osteogenic differentiation by inhibiting DKK1 during the development of steroid-associated osteonecrosis. +genetics_GWAS 30550571 hsa-mir-2110 Neuroblastoma In this study, we demonstrated that synthetic miR-2110 mimic had a generic effect on reducing cell survival in neuroblastoma cell lines with distinct genetic backgrounds, although the induction of cell differentiation traits varied between cell lines. +other 30549198 hsa-mir-101 Urinary Bladder Neck Obstruction We found the expression of microRNA-101 and hif-1alpha increased in bladder after BOO. +lncRNA target 30549198 hsa-mir-101b Urinary Bladder Neck Obstruction Then, we conclude microRNA-101b is induced by hypoxia and represses fibrosis of BSMCs by inhibiting the expression of TGFbetaR1 through TGF-beta signaling pathway, and it may be an anti-fibrotic miRNA for therapy. +circulation_biomarker_prognosis_up 30549196 hsa-mir-375 Acquired Immunodeficiency Syndrome These data suggest that circulating miR-375 might be a good indicator of active AIDS-KS. +circulation_biomarker_prognosis_up 30549196 hsa-mir-375 Sarcoma, Kaposi These data suggest that circulating miR-375 might be a good indicator of active AIDS-KS. +genetics_overexpression_promote 30549141 hsa-mir-1204 Carcinoma, Non-Small-Cell Lung It was first found that miR-1204 was overexpressed in NSCLC tissues and cells. +genetics_knock down_promote 30549038 hsa-mir-195 Laryngeal Neoplasms Finally, in vivo experiments were used to validate that knockdown of DGCR5 suppressed laryngeal carcinoma via targeting miR-195. In conclusion, we indicated that DGCR5 could contribute to the radioresistance of human laryngeal carcinoma cells via sponging miR-195. +transcription factor target 30549035 hsa-mir-21 Carcinoma, Non-Small-Cell Lung Using different NSCLC cell lines, we demonstrated that OAT promoted the proliferation, invasion, and migration, inhibited the apoptosis, and altered cell cycle of NSCLC cells; besides, the involvement of OAT-miRglycogen synthase kinase-3beta signaling in the functional role of OAT in NSCLC was also revealed. +genetics_knock down_promote 30548945 hsa-mir-16 Astrocytoma 5p overexpression inhibited proliferation and induced apoptosis in various glioma cell lines and increased sensitivity of A172 glioma cells to irradiation and TMZ. +genetics_knock down_promote 30548945 hsa-mir-16 Glioma 5p overexpression inhibited proliferation and induced apoptosis in various glioma cell lines and increased sensitivity of A172 glioma cells to irradiation and TMZ. +lncRNA target 30548682 hsa-mir-183 Cardiomyopathies CONCLUSION In vitro and in vivo study revealed that miRNA-183 improves myocardial damager through the NF-b pathway. +lncRNA target 30548664 hsa-mir-384 Laryngeal Neoplasms Moreover, results showed that miR-384 mimic remarkably inhibited LC cell proliferation, which was notably decreased by miR-384 inhibitor. +other 30548660 hsa-mir-150 Colorectal Neoplasms 504-519d expression might be a novel approach for the treatment of colorectal cancer. +other 30548660 hsa-mir-504 Colorectal Neoplasms 504-519d expression might be a novel approach for the treatment of colorectal cancer. +other 30548660 hsa-mir-519d Colorectal Neoplasms 504-519d expression might be a novel approach for the treatment of colorectal cancer. +other 30548656 hsa-mir-23b Adenocarcinoma of Lung These findings indicated that CCAT2 may act as a competitive endogenous RNA (ceRNA) to regulate FOXC1 expression by competitively binding miR-23b-5p in lung adenocarcinoma. +lncRNA target 30548623 hsa-mir-107 Atherosclerosis targeted KRT1 inhibition activated the Notch pathway, thereby, protecting against the coronary atherosclerosis. +other 30548333 hsa-mir-223 Demyelinating Diseases These results suggest miR-223 constrains neuroinflammation while also promoting repair, a finding of important pathophysiological relevance to MS as well as other neurodegenerative diseases. +circulation_biomarker_diagnosis_up 30548329 hsa-mir-29a Hepatitis, Chronic MiR-29a concentrations were significantly higher in the CH (P < .001) and LC (P < .001) groups compared to the NL group. CONCLUSIONS AND CLINICAL IMPORTANCE: Circulating miR-122 and miR-29a concentrations might be useful for monitoring the response to treatment and progression of canine CH. +circulation_biomarker_diagnosis_ns 30548329 hsa-mir-122 Hepatitis, Chronic RESULTS: Of the 5 microRNAs, only circulating miR-122 and miR-29a were significantly associated with the grade of hepatitis and the stage of fibrosis. A positive correlation was identified between the grade of hepatitis with miR-122 (r(s) = 0.79, P < .001) and miR-29a (r(s) = 0.78, P < .001). +lncRNA target 30548308 hsa-mir-340 Osteosarcoma In conclusion, OIP5-AS1 causes cisplatin resistance in osteosarcoma through inducing the LPAATbeta/PI3K/AKT/mTOR signaling pathway by sponging the miR5p. +lncRNA target 30548303 hsa-mir-29a Cardiomyopathy, Hypertrophic CONCLUSION: The results obtained in this study collectively indicated that the MIAT might be associated with the development of fibrosis (+) HCM via negatively regulating the expression of miR-29a. +genetics_overexpression_promote 30548297 hsa-mir-7 Iron Metabolism Disorders CONCLUSION: We confirmed that the overexpression of miR-7b inhibits I/R-induced apoptosis in H9C2 cells by targeting the HIF1a/p-P38 pathway. +other 30548297 hsa-mir-7 Myocardial Reperfusion Injury However, it remains largely unknown whether miR-7b is involved in the pathogenesis and progression of the AMI ischemia/reperfusion (I/R) injury. +other 30548297 hsa-mir-7b Myocardial Infarction miR-7b was reported to be downregulated in acute myocardial infarction (AMI) myocardium tissues. However, it remains largely unknown whether miR-7b is involved in the pathogenesis and progression of the AMI ischemia/reperfusion (I/R) injury. +other 30548297 hsa-mir-7b Myocardial Reperfusion Injury However, it remains largely unknown whether miR-7b is involved in the pathogenesis and progression of the AMI ischemia/reperfusion (I/R) injury. +other 30548297 hsa-mir-7 Myocardial Infarction miR-7b was reported to be downregulated in acute myocardial infarction (AMI) myocardium tissues. However, it remains largely unknown whether miR-7b is involved in the pathogenesis and progression of the AMI ischemia/reperfusion (I/R) injury. +genetics_overexpression_promote 30548297 hsa-mir-7b Iron Metabolism Disorders CONCLUSION: We confirmed that the overexpression of miR-7b inhibits I/R-induced apoptosis in H9C2 cells by targeting the HIF1a/p-P38 pathway. +genetics_GWAS 30548296 hsa-mir-124 Post-Cardiac Arrest Syndrome CONCLUSION: The presence of a minor allele, G, of miR-124 polymorphism (rs531564) reduced the expression of miRNA and upregulated the expression of CDK4, which may contribute to the effect of rs531564 on the motor function recovery in poststroke patients. +genetics_GWAS 30548296 hsa-mir-124 Stroke The current study aimed to investigate whether miR-124 polymorphism (rs531564) influences the motor function of patients after stroke. CONCLUSION: The presence of a minor allele, G, of miR-124 polymorphism (rs531564) reduced the expression of miRNA and upregulated the expression of CDK4, which may contribute to the effect of rs531564 on the motor function recovery in poststroke patients. +transcription factor target 30548198 hsa-mir-193a Breast Neoplasms We demonstrate that miR-193a-3p regulates PTP1B in BC cells and that it regulates the proliferation and apoptosis of BC cells by targeting PTP1B, both in vitro and in vivo. In conclusion, this study confirms that PTP1B acts as an oncogene in BC and demonstrates that miR-193a-3p can serve as a tumour suppressor gene in BC by targeting PTP1B. +other 30548190 hsa-mir-150 Fibrosis Taken together, we provide a novel HOTTIP-miRSRF signalling cascade in liver fibrosis. +other 30547791 hsa-let-7b Pulmonary Arterial Hypertension However, whether PDGF-BB-H19-let-7b-AT(1)R axis contributes to the pathogenesis of PAH has not been thoroughly elucidated to date. The H19-let-7b-AT(1)R axis contributed to the pathogenesis of PAH by stimulating PASMCs proliferation. +transcription factor target 30547775 hsa-mir-6845 Alzheimer Disease CONCLUSIONS Together, these findings suggest that dysregulation of hsa-miR-4487 and hsa-miR3p contributed to the pathogenesis of AD associated with A25-35 mediated by triggering cell apoptosis and synaptic dysfunction. +transcription factor target 30547775 hsa-mir-4487 Alzheimer Disease CONCLUSIONS Together, these findings suggest that dysregulation of hsa-miR-4487 and hsa-miR3p contributed to the pathogenesis of AD associated with A25-35 mediated by triggering cell apoptosis and synaptic dysfunction. +lncRNA target 30547768 hsa-mir-372 Lung Neoplasms CONCLUSION: Propofol inhibits growth, migration and invasion of lung cancer A549 cells at least in part by down-regulating miR-372 and then inactivating Wnt/beta-catenin and mTOR pathways. +lncRNA target 30546469 hsa-mir-221 Pancreatic Carcinoma In the present study, it was revealed that transfection with miR-221 mimic was able to suppress the protein expression of HDAC6 in pancreatic cancer cells compared with the negative control. +other 30546462 hsa-mir-760 Carcinoma, Hepatocellular The current results indicated that miR-760 serves as an oncogene for HCC and high expression of miR-760 is significantly associated with tumor progression and poor prognosis in patients with HCC. +lncRNA target 30546454 hsa-mir-214 Colonic Neoplasms Therefore, miR-214 can promote apoptosis of colon cancer cells SW620 by inhibiting their proliferation and invasion. +lncRNA target 30546451 hsa-mir-204 Retinoblastoma miR-204 may inhibit proliferation and promote apoptosis of RB cells through downregulating the expression of Bcl-2 and Sirt1 in RB. +lncRNA target 30546438 hsa-mir-101 Carcinoma, Non-Small-Cell Lung Survival analysis through univariate and multivariate models indicated that the miR +transcription factor target 30546428 hsa-mir-34a Liver Neoplasms Therefore, miR-34a was able to inhibit metastasis in liver cancer cells. +circulation_biomarker_diagnosis_down 30546424 hsa-mir-122 Carcinoma, Hepatocellular 5p was significantly associated with HCC tissues (P<0.001), tumor vascular invasion (P<0.001), metastasis (P=0.001), sex (P=0.006), virus infection status (P=0.001) and tissue (compared with serum; P<0.001) in cases from the GEO database. +genetics_overexpression_promote 30546422 hsa-mir-639 Nasopharyngeal Carcinoma In vitro experiments involving transfection of human NPC C666-1 and NPC/HK1 cell lines with miR-639 mimics and antagomir indicated that overexpressing miR-639 promoted cell proliferation and migration, suppression of miR-639 inhibited proliferation and migration. +genetics_overexpression_promote 30546419 hsa-mir-148a Adenocarcinoma of Lung Additional experiments demonstrated that increased E2F3 expression counteracted the inhibitory effects on lung adenocarcinoma cells caused by miR-148a overexpression. +circulation_biomarker_diagnosis_ns 30546418 hsa-mir-145 Pre-Eclampsia Furthermore, recent studies have reported that miR-145 within the preeclamptic trophoblast debris may cause the high blood pressure via interacting with the maternal endothelium. +other 30546418 hsa-mir-145 Pneumonia, Mycoplasma The aim of the present study was to investigate the functions of miR-145 in PE. The results demonstrated that miR-145 is downregulated and MUC1 is upregulated in PE tissues and cells compared with normal placenta tissues and cells. +other 30546417 hsa-mir-182 Leukemia Various studies have reported that miR5p is associated with a number of diseases, including cancer, heart disease, and leukemia. +other 30546417 hsa-mir-182 Hyperlipoproteinemia Type III These results suggested that miR5p is involved in the mechanism of THBS 1 on the modulation of beta cell survival. +other 30546417 hsa-mir-182 Heart Diseases Various studies have reported that miR5p is associated with a number of diseases, including cancer, heart disease, and leukemia. +other 30546417 hsa-mir-182 Diabetes Mellitus However, to the best of our knowledge miR5p has never been reported to be associated with diabetes. +genetics_overexpression_promote 30546411 hsa-mir-466 Osteosarcoma miR-466 overexpression suppressed CCND1 expression in OS cells. +genetics_knock down_suppress 30546401 hsa-mir-128 Colonic Neoplasms A rescue assay revealed that inhibition of miR-3128 significantly abrogated the effects of LINC01410 knockdown on CC cell proliferation and invasion. +lncRNA target 30546398 hsa-mir-671 Stomach Neoplasms 5p had a protective role in gastric cancer through inhibiting gastric cancer cell proliferation and promoting cell apoptosis by targeting URGCP. +lncRNA target 30546395 hsa-mir-21 Stomach Neoplasms Collectively, the results suggested that the miRNA expression profile in GC9811-P vs. GC9811 cells was altered to favor disease progression, and the dysregulated miRNAs, including miR5p, may therefore provide novel biomarkers and potential therapeutic targets for gastric cancer metastasis. +other 30546393 hsa-mir-143 Sepsis PVT1 was downregulated and microRNA-143 was upregulated in the myocardial tissues of sepsis rats. +circRNA target 30546088 hsa-mir-34a Carcinoma, Hepatocellular Moreover, in vitro and in vivo studies showed that exo-circ-DB promotes HCC growth and reduces DNA damage via the suppression of miR-34a and the activation of deubiquitination-related USP7. +lncRNA target 30545964 hsa-mir-320e Schizophrenia We found that the most connected transcription factor gene POU3F2, also identified on a genome-wide association study for bipolar disorder, could regulate the miRNA hsa-miR-320e and other putative target mRNAs. +other 30544973 hsa-mir-146b Encephalomyelitis, Autoimmune, Experimental Our results suggest that above-mentioned miRNAs may play a crucial role in the pathogenesis of MS, and that miR-99b, miR-125a, and miR-146b in particular may serve as useful biomarkers for disease activity. +other 30544973 hsa-mir-99b Encephalomyelitis, Autoimmune, Experimental Our results suggest that above-mentioned miRNAs may play a crucial role in the pathogenesis of MS, and that miR-99b, miR-125a, and miR-146b in particular may serve as useful biomarkers for disease activity. +other 30544973 hsa-mir-125a Encephalomyelitis, Autoimmune, Experimental Our results suggest that above-mentioned miRNAs may play a crucial role in the pathogenesis of MS, and that miR-99b, miR-125a, and miR-146b in particular may serve as useful biomarkers for disease activity. +genetics_overexpression_promote 30544959 hsa-mir-34b Thyroid Neoplasms The miR-34b overexpressed thyroid carcinoma cell lines showed reduction in VEGF-A protein expression, decreased cell proliferation, decreased wound healing, reduced cell cycle progression and increased apoptosis (p < 0.05). +genetics_overexpression_promote 30544723 hsa-mir-144 Glioblastoma 3p downregulated the overexpression of TOP2A and inhibited the proliferation, clone formation, and invasion of HCMV-positive glioma in vitro. +lncRNA target 30544640 hsa-mir-19a Thyroid Neoplasms These findings not only suggest that miR-19a has a possible involvement in de-differentiation and malignancy, but also that it could represent an important prognostic indicator and a good therapeutic target for the most aggressive thyroid cancer. +tissue_expression_ns 30544640 hsa-mir-19a Adenocarcinoma, Follicular To this aim, we induced miR-19a expression in the well-differentiated follicular thyroid cancer cell line and evaluated proliferation, apoptosis and gene expression profile of cancer cells. +other 30544204 hsa-mir-93 Diabetes Mellitus Thus, for the first time, we identified the MEG3/miR-93/p21 axis in HUVECs treated with AGE-BSA, which might be a novel regulatory network in diabetic vascular cells, and possess the potential therapeutic value for diabetes mellitus. +genetics_overexpression_promote 30544100 hsa-mir-192 Prostatic Neoplasms RESULTS: By analyzing the dataset of TCGA, we found that miR-192 was overexpressed in PCa samples compared to normal tissues and was upregulated in high-grade PCa compared to low-grade PCa. +genetics_knock down_promote 30544064 hsa-mir-92b Carcinoma, Hepatocellular Through directly binding to the 3'-UTR of p57kip2, miR-92b negatively regulated the protein levels of p57kip2; miR-92b inhibition enhanced the cell effect of IR on HCC cells, which could be attenuated by the p57kip2 knockdown, in other words, miR-92b modulated the radioresistance of HCC to IR-based radiotherapy through p57kip2. +transcription factor target 30543885 hsa-mir-93 Prostatic Neoplasms Our study suggests that miR-93 promoted PC progression and metastasis by repressing DAB2 to activate Akt/ERK1/2 pathway, and elevation of DAB2 and inactivation of Akt/ERK1/2 might be a potential therapeutic target for PC by GTP. +genetics_knock down_promote 30543848 hsa-mir-15b Carcinoma, Hepatocellular RESULTS: H19 and CDC42 were up-regulated while miR-15b was down-regulated in HCC cells and tissues. CONCLUSION: H19 knockdown inhibited proliferation, migration and invasion, and promoted apoptosis of HCC cells via targeting miR-15b/CDC42/PAK1 axis. +lncRNA target 30543563 hsa-mir-340 Melanoma In melanoma cancer cells, inhibition of miR-340 led to increased PKCalpha protein levels. +other 30543501 hsa-mir-1 Cachexia Whereas the expression of miR-1, miR-206, miR-486, and miR-29b was upregulated in the muscle biopsies of patients with COPD compared with those of healthy controls, levels of none of the studied micro-RNAs in the myotubes (primary cultured cells) significantly differed between patients with COPD and the controls. +other 30543501 hsa-mir-486 Cachexia Whereas the expression of miR-1, miR-206, miR-486, and miR-29b was upregulated in the muscle biopsies of patients with COPD compared with those of healthy controls, levels of none of the studied micro-RNAs in the myotubes (primary cultured cells) significantly differed between patients with COPD and the controls. +other 30543501 hsa-mir-29b Cachexia Whereas the expression of miR-1, miR-206, miR-486, and miR-29b was upregulated in the muscle biopsies of patients with COPD compared with those of healthy controls, levels of none of the studied micro-RNAs in the myotubes (primary cultured cells) significantly differed between patients with COPD and the controls. +other 30543501 hsa-mir-206 Cachexia Whereas the expression of miR-1, miR-206, miR-486, and miR-29b was upregulated in the muscle biopsies of patients with COPD compared with those of healthy controls, levels of none of the studied micro-RNAs in the myotubes (primary cultured cells) significantly differed between patients with COPD and the controls. +tissue_expression_ns 30543324 hsa-mir-34a autosomal recessive osteopetrosis 7 Although playing little role in regular homeostasis, miR-34a deficiency leads to colon tumorigenesis after Citrobacter rodentium infection. +lncRNA target 30543177 hsa-let-7a Stomach Neoplasms OBJECTIVE: We aimed to study alterations in the expression of Let-7a and miR-21, and their targets in gastric cancer cell lines after treatment with docetaxel. CONCLUSION: Down-regulation and up-regulation of Let-7a in docetaxel-resistant and sensitive cell lines, respectively indicates its potential usefulness as biomarker for responsiveness of gastric cancer to the therapy with docetaxel and also for predicting patient;s outcome. +lncRNA target 30543171 hsa-mir-107 Alzheimer Disease OBJECTIVE: We aimed to study the miR-107 in Alzheimer's Disease (AD) pathology through regulating SYK and NF-kappaB signaling pathway. +genetics_overexpression_promote 30542723 hsa-mir-381 Carcinoma, Endometrioid The observed decrease in miR381 in ovarian cancer could be reversed upon overexpression of the gene encoding the tumor suppressor homeobox D10. +other 30542718 hsa-mir-224 Prostatic Neoplasms The results suggested that the downregulated expression of miR2245p may be associated with the clinical progression and prognosis of PCa. +lncRNA target 30542715 hsa-mir-194 Stomach Neoplasms Finally, the results indicated that cell apoptosis was markedly increased in response to miR194 inhibition, strongly suggesting the carcinogenic effects of miR194 in GC. +transcription factor target 30542710 hsa-mir-144 Lung Neoplasms In the course of the study, we unexpectedly found that miR1443p could regulate the cisplatin resistance of lung cancer cells via Nrf2. +circulation_biomarker_diagnosis_up 30542708 hsa-mir-21 Papillary Thyroid Microcarcinoma miR222, miR221, miR146b and miR21 levels were determined using reverse transcriptionquantitative polymerase chain reaction (RTqPCR) in serum from 58 patients with PTMC and 47 with PTC, 35 patients with benign thyroid nodules (BTN) and 40 control subjects. The results indicated that miR222, miR221, miR146b and miR21 expression levels were higher in the PTMC samples than in those from the BTN and control groups and the combination of miRNAs and US had a high sensitivity and specificity for discrimination between BTN and PTMC by receiver operating characteristic (ROC) curve analysis and improved the accuracy of diagnosis of PTMC before surgery. +circulation_biomarker_diagnosis_up 30542708 hsa-mir-146b Papillary Thyroid Microcarcinoma miR222, miR221, miR146b and miR21 levels were determined using reverse transcriptionquantitative polymerase chain reaction (RTqPCR) in serum from 58 patients with PTMC and 47 with PTC, 35 patients with benign thyroid nodules (BTN) and 40 control subjects. The results indicated that miR222, miR221, miR146b and miR21 expression levels were higher in the PTMC samples than in those from the BTN and control groups and the combination of miRNAs and US had a high sensitivity and specificity for discrimination between BTN and PTMC by receiver operating characteristic (ROC) curve analysis and improved the accuracy of diagnosis of PTMC before surgery. +circulation_biomarker_diagnosis_up 30542708 hsa-mir-221 Papillary Thyroid Microcarcinoma miR222, miR221, miR146b and miR21 levels were determined using reverse transcriptionquantitative polymerase chain reaction (RTqPCR) in serum from 58 patients with PTMC and 47 with PTC, 35 patients with benign thyroid nodules (BTN) and 40 control subjects. The results indicated that miR222, miR221, miR146b and miR21 expression levels were higher in the PTMC samples than in those from the BTN and control groups and the combination of miRNAs and US had a high sensitivity and specificity for discrimination between BTN and PTMC by receiver operating characteristic (ROC) curve analysis and improved the accuracy of diagnosis of PTMC before surgery. +circulation_biomarker_diagnosis_up 30542708 hsa-mir-222 Papillary Thyroid Microcarcinoma miR222, miR221, miR146b and miR21 levels were determined using reverse transcriptionquantitative polymerase chain reaction (RTqPCR) in serum from 58 patients with PTMC and 47 with PTC, 35 patients with benign thyroid nodules (BTN) and 40 control subjects. The results indicated that miR222, miR221, miR146b and miR21 expression levels were higher in the PTMC samples than in those from the BTN and control groups and the combination of miRNAs and US had a high sensitivity and specificity for discrimination between BTN and PTMC by receiver operating characteristic (ROC) curve analysis and improved the accuracy of diagnosis of PTMC before surgery. +genetics_overexpression_promote 30542706 hsa-mir-182 Gastrointestinal Stromal Tumors Overexpression of miR-182 enhanced GIST-T1 cell growth, with increased proliferation and decreased apoptosis. +other 30542696 hsa-mir-885 Colorectal Neoplasms In vitro experiments were performed to demonstrate that miR885 promoted CRC cell migration by, at least partially, decreasing the expression of von Willebrand factor (vWF) and insulinlike growth factor binding protein 5 (IGFBP5). +other 30542553 hsa-mir-132 Acute Disease Analysis of miR-132 and miR-146a from acute monocytic leukemia cells (THP-1) demonstrated the broad applicability to different miRNAs and other types of clinical samples. +other 30542553 hsa-mir-146a Acute Disease Analysis of miR-132 and miR-146a from acute monocytic leukemia cells (THP-1) demonstrated the broad applicability to different miRNAs and other types of clinical samples. +circulation_biomarker_diagnosis_ns 30542553 hsa-mir-21 Breast Neoplasms Quantification of miR-21 from human tissues and plasma samples revealed the relevance for breast and ovarian cancer diagnostics. +other 30542509 hsa-mir-200 Pancreatic Carcinoma Finally, whereas human malignant pancreatic tissues (PDACs) express lower miR-200 levels than non malignant tissues (non-MPDs), MCPiP1/Dicer1 ratio appears higher in PDACs, when compared to non-MPDs, supporting the hypothesis that MCPiP1/Dicer1 ratio is determinant in regulating miR-200 maturation process in a subset of tumoral pancreatic cells. +other 30542492 hsa-mir-423 Alveolar Bone Loss 5p) were previously reported to be involved in bone metabolism. +other 30542492 hsa-mir-148b Alveolar Bone Loss 5p) were previously reported to be involved in bone metabolism. +other 30542492 hsa-mir-337 Alveolar Bone Loss 5p) were previously reported to be involved in bone metabolism. +genetics_overexpression_promote 30542452 hsa-mir-455 Esophageal Squamous Cell Carcinoma In vitro overexpression of miR +lncRNA target 30542447 hsa-mir-214 Stomach Neoplasms Downregulation of miR-214 expression or upregulation of Dact2 expression inhibited the migration and invasion of mixed gastric adenocarcinoma type MKN28 cells. +genetics_overexpression_promote 30542444 hsa-mir-4492 Colorectal Neoplasms Furthermore, it was demonstrated that overexpression of LINC01503 reduced the availability of miR-4492 in CRC cells. +circulation_biomarker_diagnosis_up 30542439 hsa-mir-26a Neonatal Sepsis The present study aimed to investigate the expression of microRNA (miRNA) 26a in blood mononuclear cells and serum in neonatal sepsis, as well as its role in the disease pathogenesis. The expression of IL-6 was significantly upregulated in the blood mononuclear cells and serum in neonatal sepsis, which may be associated with the downregulation of miRNA-26a. +genetics_overexpression_promote 30542435 hsa-mir-218 Stomach Neoplasms Results also demonstrated that miR-218 was overexpressed in SGC7901/DDP cells and that the downregulation of survivin expression enhanced SGC7901/DDP cell sensitivity to DDP. +transcription factor target 30542430 hsa-mir-373 Melanoma In conclusion, the present study indicates that miR-373 functions as an oncomiR to promote melanoma progression through targeting SIK1 expression. +genetics_knock down_promote 30542424 hsa-mir-23b Sepsis The expression of microRNA-23b in peripheral blood leukocytes from 87 patients with sepsis, 50 patients with systemic inflammatory response syndrome (SIRS) and 50 normal controls were measured by reverse transcription-quantitative PCR (RT-qPCR), and stability of microRNA-23b was evaluated. +other 30542422 hsa-mir-183 Aortic Aneurysm, Abdominal miR-183 and miR-141 can be used as predictors of prognosis in patients with IAAA. +other 30542422 hsa-mir-141 Aortic Aneurysm, Abdominal miR-183 and miR-141 can be used as predictors of prognosis in patients with IAAA. +other 30542421 hsa-mir-4784 Cartilage Diseases In summary, the results of the present study suggest that miRNA-4784 expression is significantly reduced in early stage OA chondrocytes. +other 30542421 hsa-mir-4784 Osteoarthritis In summary, the results of the present study suggest that miRNA-4784 expression is significantly reduced in early stage OA chondrocytes. +transcription factor target 30542417 hsa-mir-21 Carcinoma, Non-Small-Cell Lung 5p promote the proliferation of NSCLC cells via inhibiting TGFBI expression. +genetics_overexpression_suppress 30542412 hsa-mir-21 Acute Lung Injury LPS-induced ALI in rats resulted in significant overexpression of pro-inflammatory cytokines, TNF-alpha, IL-6 and IL-1beta, and miR-21, but reduced the expression of the anti-inflammatory cytokine IL-10. +other 30542402 hsa-mir-106b Retinoblastoma The present study demonstrated that increased expression of miR-106b in RB tissues is positively associated with the metastasis and differentiation of RB cells. +genetics_overexpression_promote 30542388 hsa-mir-34a Breast Neoplasms In addition, the role of miR-34a in MCF-7 breast cancer cells was investigated by performing miR-34a overexpression or downregulation through transfection with miR-34a mimic or inhibitor, respectively. +circulation_biomarker_diagnosis_ns 30542386 hsa-mir-155 Coronary Artery Disease In conclusion, in the patients with coronary heart disease the apoptosis rate of PBMCs was increased and the expression of miR-155 in plasma and PBMCs cells was decreased, which were correlated with the severity of coronary heart disease. +other 30542210 hsa-mir-29b Fibrosis Diminished microRNA-29b levels have recently been revealed to provoke increased expression and accumulation of extracellular matrix molecules, such as collagens in fibrotic remodeling. +circulation_biomarker_diagnosis_ns 30541960 hsa-mir-518e Gastrointestinal Stromal Tumors These data indicate that serum miR-518e- 5p is a potentially promising non-invasive biomarker for early detection and diagnosis of secondary imatinib-resistant GIST. +circulation_biomarker_diagnosis_ns 30541960 hsa-mir-518e Tuberculosis, Multidrug-Resistant These data indicate that serum miR-518e- 5p is a potentially promising non-invasive biomarker for early detection and diagnosis of secondary imatinib-resistant GIST. +genetics_overexpression_promote 30541951 hsa-mir-92a Arthritis, Rheumatoid Moreover, AKT2 overexpression rescued miR-92a-mediated suppressive effect on proliferation and migration of RA-FLS. +lncRNA target 30541899 hsa-mir-125 Arthritis, Rheumatoid Thus, miR-125 might attenuate RA development by regulating PI3K/Akt/mTOR signaling pathway via directly inhibiting PARP2 expression. +exosome 30541743 hsa-mir-186 Neuroblastoma containing nanoparticle formulation to prevent tumor growth and TGFbeta1-dependent immune escape in high-risk neuroblastoma patients as well as the inclusion of ex vivo-derived NK exosomes as a potential therapeutic option alongside NK cell-based immunotherapy.Significance: These findings highlight the therapeutic potential of NK cell-derived exosomes containing the tumor suppressor miR-186 that inhibits growth, spreading, and TGFbeta-dependent immune escape mechanisms in neuroblastoma. +other 30540564 hsa-mir-144 Thyroid Neoplasms We investigated the influence of circEIF6 (Hsa_circ_0060060) on the cisplatin-sensitivity in papillary thyroid carcinoma (PTC) and ATC cells, and explored its regulation to downstream molecules miR3p and Transforming Growth Factor alpha (TGF-alpha). +transcription factor target 30540563 hsa-mir-19 Memory Disorders Together, our data suggest that SEVO-induced upregulation of miR3p post-transcriptionally inhibits CCNA2, which contributes to the SEVO-associated impairment of learning and memory of the neonatal rats. +lncRNA target 30539857 hsa-mir-370 Liver Neoplasms The underlying molecular mechanism was that miR-370 inhibited cell proliferation of liver cancer cells by activating FoxO3a. +transcription factor target 30539837 hsa-mir-27a Carcinoma, Non-Small-Cell Lung In addition, we showed that miR-27a regulates proliferation, migration, and invasion in H1650 cell line and demonstrated that miR-27a expression was positively related to epidermal growth factor receptor in NSCLC cell lines. miR-27a may be a potential target for NSCLC therapy. +other 30539823 hsa-mir-99 Cranial Nerve Injuries Our results confirmed that increased miR-3099 level induced by peripheral nerve injury can promote the proliferation and migration of Schwann cells. +other 30539823 hsa-mir-99 Peripheral Nerve Injuries Our results confirmed that increased miR-3099 level induced by peripheral nerve injury can promote the proliferation and migration of Schwann cells. +other 30539823 hsa-mir-99 Sciatic Neuropathy Real-time reverse transcription-polymerase chain reaction was used to determine miR-3099 expression in the crushed nerve segment at 0, 1, 4, 7, and 14 days post sciatic nerve injury, which was consistent with Solexa sequencing outcomes. +transcription factor target 30539797 hsa-mir-122 Carcinoma, Hepatocellular CONCLUSION: Our study fully demonstrated that miR-122 inhibits MDR1 expression via suppression of Wnt/beta-catenin pathway, thereby enhancing HCC sensitivity to OXA. +genetics_overexpression_promote 30539753 hsa-mir-34b Reperfusion Injury, Cerebral Ischemia After focal cerebral I/R, miR-34b expression was downregulated in a time-dependent manner; miR-34b overexpression ameliorated I/R-induced oxidative stress injury in middle cerebral artery occlusion (MCAO) rats by reducing the infarction volume, the neurological severity scores, the levels of nitric oxide (NO) and (3-nitrotyrosine) 3-NT while increasing total (superoxide dismutases) SOD and manganese SOD (MnSOD). Taken together, we demonstrate that miR-34b protects against focal cerebral I/R-induced oxidative stress injury in MCAO rats and H2O2-induced oxidative stress injury in rat neuroblast B35 cells through targeting Keap1 and downstream Keap1/Nrf2 signaling pathway. +genetics_GWAS 30539710 hsa-mir-224 Coronary Artery Disease Results show that the miR-224 (rs188519172 A>G) polymorphism was associated with a decreased risk to CAD in a codominant model, GA genotype vs. +other 30539522 hsa-mir-22 Thyroid Neoplasms In this study, we for the first time showed MIR22HG was down-regulated in thyroid cancer by analyzing public datasets, including TCGA, GSE29265, GSE33630, and GSE55091. These results suggested MIR22HG could serve as a novel biomarker for thyroid cancer. +lncRNA target 30539420 hsa-mir-9 Ischemic Stroke Hence, this study unleashes a potential therapeutic approach that integrates neuronal survival and regeneration via small-molecule-based regulation of miR-9 favoring long-term recovery against ischemic stroke. +genetics_overexpression_promote 30539341 hsa-mir-101 Glioblastoma Both overexpression of miR +transcription factor target 30539011 hsa-mir-4739 Diabetes Mellitus miRNA-4739 is implicated as a novel diagnostic marker and a potential therapeutic target for CLI in diabetes. +transcription factor target 30539011 hsa-mir-4739 Chronic Limb-Threatening Ischemia miRNA-4739 is implicated as a novel diagnostic marker and a potential therapeutic target for CLI in diabetes. +other 30538784 hsa-mir-155 Carcinoma, Non-Small-Cell Lung These subgroup analyses also highlighted that elevated expression of miR-21 and miR-155 and low levels of expression of miR-148a, miR-148b, and miR-let-7 were associated with poor prognosis in NSCLC. CONCLUSION: miR-21, miR-155, miR-148a, miR-148b, and miR-let-7 are consistently up- or downregulated in NSCLC and are associated with poor OS. +other 30538784 hsa-let-7 Carcinoma, Non-Small-Cell Lung These subgroup analyses also highlighted that elevated expression of miR-21 and miR-155 and low levels of expression of miR-148a, miR-148b, and miR-let-7 were associated with poor prognosis in NSCLC. CONCLUSION: miR-21, miR-155, miR-148a, miR-148b, and miR-let-7 are consistently up- or downregulated in NSCLC and are associated with poor OS. +other 30538784 hsa-mir-21 Carcinoma, Non-Small-Cell Lung These subgroup analyses also highlighted that elevated expression of miR-21 and miR-155 and low levels of expression of miR-148a, miR-148b, and miR-let-7 were associated with poor prognosis in NSCLC. CONCLUSION: miR-21, miR-155, miR-148a, miR-148b, and miR-let-7 are consistently up- or downregulated in NSCLC and are associated with poor OS. +other 30538784 hsa-mir-148a Carcinoma, Non-Small-Cell Lung These subgroup analyses also highlighted that elevated expression of miR-21 and miR-155 and low levels of expression of miR-148a, miR-148b, and miR-let-7 were associated with poor prognosis in NSCLC. CONCLUSION: miR-21, miR-155, miR-148a, miR-148b, and miR-let-7 are consistently up- or downregulated in NSCLC and are associated with poor OS. +other 30538784 hsa-mir-148b Carcinoma, Non-Small-Cell Lung These subgroup analyses also highlighted that elevated expression of miR-21 and miR-155 and low levels of expression of miR-148a, miR-148b, and miR-let-7 were associated with poor prognosis in NSCLC. CONCLUSION: miR-21, miR-155, miR-148a, miR-148b, and miR-let-7 are consistently up- or downregulated in NSCLC and are associated with poor OS. +other 30538705 hsa-mir-155 Central Nervous System Bacterial Infections MicroRNA (miR) miR-155 modulates microglial activation and polarization, but its role in activation of microglia during bacterial brain infection is unclear. +lncRNA target 30538705 hsa-mir-155 Encephalitis Thus, miR-155 affects brain inflammation by multiple mechanisms during neuroinvasive L. Peripheral miR-155 promotes brain inflammation through its required role in optimal development of IFN-gamma-secreting lymphocytes that enter the brain and activate microglia. +transcription factor target 30538632 hsa-mir-122 Liver Cirrhosis This study provides partial evidence that STF-083010 alleviated CCl(4)-induced liver injury and thus protected against liver fibrosis associated with hepatic miR-122. +transcription factor target 30538632 hsa-mir-122 Liver Injury This study provides partial evidence that STF-083010 alleviated CCl(4)-induced liver injury and thus protected against liver fibrosis associated with hepatic miR-122. +lncRNA target 30538565 hsa-mir-299 Thyroid Cancer, Papillary 5p could participate in PTC migration and invasion and could be a potential therapeutic target for patients with aggressive PTC tumors. +other 30538543 hsa-mir-27a Breast Neoplasms The level of miR-181a expression in ER-positive cancer was higher than that in ER-negative cancer, while the expression of miR-27a, miR-107, and miR-195 was lower in ER-positive compared with ER-negative cancer. +other 30538543 hsa-mir-195 Breast Neoplasms The level of miR-181a expression in ER-positive cancer was higher than that in ER-negative cancer, while the expression of miR-27a, miR-107, and miR-195 was lower in ER-positive compared with ER-negative cancer. +other 30538543 hsa-mir-181a Breast Neoplasms The level of miR-181a expression in ER-positive cancer was higher than that in ER-negative cancer, while the expression of miR-27a, miR-107, and miR-195 was lower in ER-positive compared with ER-negative cancer. +other 30538543 hsa-mir-107 Breast Neoplasms The level of miR-181a expression in ER-positive cancer was higher than that in ER-negative cancer, while the expression of miR-27a, miR-107, and miR-195 was lower in ER-positive compared with ER-negative cancer. +exosome 30538455 hsa-mir-150 Breast Neoplasms MATERIALS AND METHODS: In this study, we exploited the exosomes isolated from bone marrow-derived mesenchymal stem cells (MSCs-Exo) to deliver LNA (locked nucleic acid)-modified anti-miR +exosome 30538455 hsa-mir-142 Breast Neoplasms MATERIALS AND METHODS: In this study, we exploited the exosomes isolated from bone marrow-derived mesenchymal stem cells (MSCs-Exo) to deliver LNA (locked nucleic acid)-modified anti-miR +circulation_biomarker_prognosis_ns 30538440 hsa-mir-190a Hypertension, Pulmonary The circulating levels of miR-190a-5p correlate with the severity of COPD-PH, thereby confirming the diagnostic and prognostic value of this parameter in COPD-PH. +lncRNA target 30538437 hsa-mir-34a Muscular Atrophy CONCLUSION: has-miR-19a and hsa-miR-34a may play regulatory roles in the aging process of skeletal muscles and may be candidate targets to prevent muscle aging. +lncRNA target 30538437 hsa-mir-19a Muscular Atrophy CONCLUSION: has-miR-19a and hsa-miR-34a may play regulatory roles in the aging process of skeletal muscles and may be candidate targets to prevent muscle aging. +other 30538177 hsa-mir-7 Brain Ischemia Our findings suggest that miR-7 mimics may therapeutically minimize stroke-induced brain damage and disability. +other 30538177 hsa-mir-7a Brain Ischemia We previously showed that transient focal ischemia in a rat model induces extensive temporal changes in the expression of cerebral microRNAs, with a sustained decrease in the abundance of miR-7a-5p (miR-7). +lncRNA target 30537994 hsa-mir-153 Glioma 3p is a potential target to enhance the effect of radiosensitivity on glioma cells, thus representing a new potential therapeutic target for glioma. +lncRNA target 30537987 hsa-mir-140 Triple Negative Breast Neoplasms 3p and by using cell-based and in vivo model systems we have demonstrated the utility of targeting downstream pathways for prevention of TNBC. +circulation_biomarker_diagnosis_ns 30537863 hsa-mir-33a Insulin Resistance CONCLUSION Ageing influenced the relationship of circulating miR-33 a and miR-33 b with insulin resistance and increased adiposity. +circulation_biomarker_diagnosis_ns 30537863 hsa-mir-3a Metabolic Diseases In this study, we aimed to identify differences in circulating miR-33 a/b levels according to age-related metabolic impairment and increased adiposity. +circulation_biomarker_diagnosis_ns 30537863 hsa-mir-33a Glucose Metabolism Disorders RESULTS Circulating miR-33 a and miR-33 b levels showed significant association with fatness, the lipid profile and biomarkers of impaired glucose metabolism. +lncRNA target 30537734 hsa-mir-149 Carcinoma, Hepatocellular SNHG8 acted as a sponge of miR-149 and counteracted the tumor suppressive effects of mi R-149 in HCC cells. +lncRNA target 30537730 hsa-mir-494 Stomach Neoplasms Mechanically, Luciferase reporter assays proved that survivin was the target of miR-494 in gastric cancer cells. +genetics_overexpression_promote 30537729 hsa-mir-21 Pancreatitis In addition, we found Hmgb1 stimulation resulted in the overexpression of miR-21 in peripheral blood mononuclear cells, and deletion of miR-21 led to a reduction of caerulein-induced acute pancreatitis-associated lung injury by repressing Hmgb1 expression. +other 30537722 hsa-mir-93 pancreatic adenocarcinoma METHODS: We assessed mRNA levels of Nrf2 and Keap1 and tissue expression of miR-93 and miR-200a in 51 patients with surgically treated PDAC. CONCLUSIONS: High miR-93 and miR-200a levels in cancer cells of PDAC were associated with better differentiation, and miR-200a expression in benign tissue with excellent RFS. +other 30537722 hsa-mir-200a pancreatic adenocarcinoma METHODS: We assessed mRNA levels of Nrf2 and Keap1 and tissue expression of miR-93 and miR-200a in 51 patients with surgically treated PDAC. CONCLUSIONS: High miR-93 and miR-200a levels in cancer cells of PDAC were associated with better differentiation, and miR-200a expression in benign tissue with excellent RFS. +genetics_overexpression_promote 30537505 hsa-mir-181c Breast Neoplasms Induced overexpression of miR-181c significantly inhibited cell proliferation, reversed the chemoresistance towards doxorubicin, and reduced the growth of resistant breast cancer xenograft tumors in vitro and in vivo. +lncRNA target 30537410 hsa-mir-34c Ovarian Neoplasms We screened for candidate microRNAs (miRNAs) which might target SOX9 using online tools and further verified the effect of miR-34c, one of the candidate miRNA that significantly inhibited SOX9 expression, in the regulation of OC cell proliferation and chemoresistance to DDP. +lncRNA target 30537266 hsa-mir-146a Stomach Neoplasms Functional studies showed that miR-146a acts as a tumor suppressor miR and identifies miR-146a as a candidate for antimetastatic miRNA replacement therapy for gastric cancer patients. +circulation_biomarker_diagnosis_ns 30537232 hsa-mir-221 Prostatic Neoplasms METHODS: The relative expression of four miRNAs (miRNA-21, -93, -125b, and miRNA-221) was assessed in plasma from 149 newly diagnosed patients with local or locally advanced PCa. CONCLUSIONS: The current results indicate a possible role of miRNA-93 and miRNA-221 in disease monitoring in localized and locally advanced PCa. +lncRNA target 30537206 hsa-mir-486 Carcinoma, Renal Cell 5p in RCC, to obtain a deeper insight into the network and to better understand the role of these microRNAs and their targets in carcinogenesis of RCC. +lncRNA target 30537177 hsa-mir-1254 Colorectal Neoplasms Investigation of the underlying mechanism showed that ABHD11-AS1 could act as a molecular sponge of miR-1254, and WNT11 was a downstream target of miR-1254 in CRC. +lncRNA target 30537154 hsa-mir-758 Ovarian Neoplasms CASC9 inhibits the level of miR +lncRNA target 30537115 hsa-mir-484 Carcinoma, Hepatocellular Rescue experiments showed that miR-484 mimics can reverse the tumor-suppressing roles of circADAMTS13 in HCC. Therefore, our results demonstrated that circADAMTS13 can serve as a tumor suppressor during HCC progression via the functional pathway of sponging miR-484. +other 30537113 hsa-mir-202 Carcinoma, Hepatocellular We address that NORAD has a tumor-promoting effect in HCC and describes a novel mechanism whereby NORAD regulates the TGF-beta pathway as a ceRNA of Homo sapiens (hsa)-miR5p. +lncRNA target 30537038 hsa-mir-23b Reperfusion Injury Our results indicate that silencing miR-23b could act to attenuate IRI and reduce the apoptosis of articular chondrocytes through inactivation of the p53 signaling pathway by upregulating MDM4, which provide basic therapeutic considerations for a novel target against IRI. +lncRNA target 30537034 hsa-mir-133a Esophageal Squamous Cell Carcinoma CONCLUSIONS: miR-133a-3p inhibited the cell propagation, invasion, and migration and facilitated apoptosis in ESCC by targeting COL1A1. +genetics_knock down_suppress 30536996 hsa-mir-143 Colorectal Neoplasms 3p mimics as examined by western blot, and the metastasis potential of CRC cells was attenuated by endogenous ITGA6 and ASAP3 knockdown, determined by migration and invasion assays. +exosome 30536969 hsa-mir-125a Carcinoma, Hepatocellular Functional studies revealed that the HCC cells were treated with TAM exosomes or transfected with miR-125a/b suppressed cell proliferation and stem cell properties by targeting CD90, a stem cell marker of HCC stem cells. The study indicated that miR-125a/b targeting CD90 played important roles in cancer stem cells of HCC. +exosome 30536969 hsa-mir-125b Carcinoma, Hepatocellular Functional studies revealed that the HCC cells were treated with TAM exosomes or transfected with miR-125a/b suppressed cell proliferation and stem cell properties by targeting CD90, a stem cell marker of HCC stem cells. The study indicated that miR-125a/b targeting CD90 played important roles in cancer stem cells of HCC. +lncRNA target 30536950 hsa-mir-383 Nasopharyngeal Carcinoma 3p/HMGA2 axis, indicating HOXC13-AS may be a potential therapeutic target for patients with NPC. +circulation_biomarker_prognosis_ns 30536846 hsa-mir-371a Neoplasms, Germ Cell and Embryonal miR-371a-3p is a new liquid biopsy biomarker for (T)GCTs. This study demonstrates clinical value of plasma miR-371a-3p level in chemotherapy naive (T)GCT patients starting first line of chemotherapy to predict prognosis. +genetics_GWAS 30536836 hsa-mir-148a Carcinoma, Non-Small-Cell Lung Because of that, miR-148a-3p and SOS2 may be an efficient target in developing more useful therapies against NSCLC. +other 30536700 hsa-mir-18a FG syndrome We propose that aberrant regulation of H19/miR-18a-5p-mediated regulatory pathway may contribute to the molecular mechanism of FGR. +other 30536654 hsa-mir-96 Diabetes, Gestational We found that miR-96 was the most down-regulated miRNA in GDM samples. Our findings demonstrate that miR-96 plays a critical role in GDM development by regulating PAK1 expression, insulin secretion, and beta-cell function. +genetics_overexpression_promote 30536619 hsa-mir-16 Prostatic Neoplasms Furthermore, overexpression of miR +lncRNA target 30536600 hsa-mir-627 Pulmonary Fibrosis In conclusion, miR-627 may be a potential agent that targets HMGB1 to inhibit its expression, thereby improving TGF-beta1-induced PF in vitro. +exosome 30536597 hsa-mir-92a high grade glioma Here, we report that hypoxia-induced glioma cells can stimulate the differentiation of functional MDSCs by transferring exosomal miR-29a and miR-92a to MDSCs. Altogether, the results of our study provide new insights into the role of glioma exosomal miRNAs in mediating the formation of immunosuppressive microenvironments in tumors and elucidate the underlying exosomal miR-29a/miR-92a-based regulatory mechanism responsible for the modulation of functional MDSC induction. +exosome 30536597 hsa-mir-29a high grade glioma Here, we report that hypoxia-induced glioma cells can stimulate the differentiation of functional MDSCs by transferring exosomal miR-29a and miR-92a to MDSCs. Altogether, the results of our study provide new insights into the role of glioma exosomal miRNAs in mediating the formation of immunosuppressive microenvironments in tumors and elucidate the underlying exosomal miR-29a/miR-92a-based regulatory mechanism responsible for the modulation of functional MDSC induction. +transcription factor target 30536412 hsa-mir-608 Small Cell Lung Carcinoma RESULTS: Eleven OS-relevant miRNAs were obtained, and hsa-miR-194, hsa-miR-608, and hsa-miR-9 were further refined through RFS. +transcription factor target 30536412 hsa-mir-194 Small Cell Lung Carcinoma RESULTS: Eleven OS-relevant miRNAs were obtained, and hsa-miR-194, hsa-miR-608, and hsa-miR-9 were further refined through RFS. +transcription factor target 30536412 hsa-mir-9 Small Cell Lung Carcinoma RESULTS: Eleven OS-relevant miRNAs were obtained, and hsa-miR-194, hsa-miR-608, and hsa-miR-9 were further refined through RFS. +lncRNA target 30536379 hsa-mir-135a Glioma Through online databases, luciferase reporter assays and RNA immunoprecipitation (RIP) assays, we determined that GACAT3 acts as a competing endogenous RNA (ceRNA) for microRNA (miR)-135a, which was downregulated and performed as a tumor inhibitor in glioma. Overall, the present study was the first to show that GACAT3 regulates the expression of NAMPT to promote glioma progression by sponging miR-135a. +circulation_biomarker_diagnosis_down 30536336 hsa-mir-940 Cerebral Infarction RESULTS: The expression level of miR-940 in serum and brain tissues of rats was markedly decreased at 1, 3, and 7 days after cerebral infarction, which was then recovered on the 7th day. +transcription factor target 30536330 hsa-mir-216a Respiratory Distress Syndrome, Newborn OBJECTIVE: To explore whether miR-216a-3p could promote differentiation of bone marrow mesenchymal stem cells (BMMSCs) into type II alveolar epithelial cells (ACE II) via Wnt/beta-catenin pathway, thereby alleviating neonatal respiratory distress syndrome (NRDS). +genetics_knock down_promote 30536330 hsa-mir-216a Norrie disease OBJECTIVE: To explore whether miR-216a-3p could promote differentiation of bone marrow mesenchymal stem cells (BMMSCs) into type II alveolar epithelial cells (ACE II) via Wnt/beta-catenin pathway, thereby alleviating neonatal respiratory distress syndrome (NRDS). CONCLUSIONS: Knockdown of miR-216a-3p induces differentiation of BMMSCs into ACE II cells through Wnt/beta-catenin pathway, thereby alleviating NRDS. +other 30536328 hsa-mir-21 Liver Neoplasms This study aims to investigate the effects of small interfere microRNA-21 RNA (miR-21 RNAi) on cell proliferation, invasive ability of high-invasion liver cancer stem cells (H-ILCSCs), HCCLM3 and HL-7702 cells. +lncRNA target 30536324 hsa-mir-638 Glioma MiR-638 regulates cellular malignancy of gliomas through targeting HOXA9. +genetics_overexpression_promote 30536321 hsa-mir-582 Carcinoma, Non-Small-Cell Lung Functional experiments demonstrated that overexpression of miR +other 30536320 hsa-mir-186 Breast Neoplasms SNHG7 could promote malignant progression of BC by regulating microRNA-186. +genetics_overexpression_promote 30536319 hsa-mir-495 Carcinoma, Non-Small-Cell Lung Overexpression of miR-495 inhibited the migration, invasion and proliferation of NSCLC cells. +transcription factor target 30536318 hsa-mir-520b Carcinoma, Non-Small-Cell Lung CONCLUSIONS: We discovered the inhibitory function of miR-520b in NSCLC by targeting CHAF1A. +other 30536317 hsa-mir-21 Mouth Neoplasms This study manipulated miR-21 expression in cultured oral cancer cells and aimed to investigate its effects on TNF-alpha expression, and on proliferation or apoptosis of cancer cells. +genetics_knock down_promote 30536316 hsa-mir-218 Squamous Cell Carcinoma of Head and Neck MicroRNA-218 knockdown OSCC cell lines were established. +other 30536313 hsa-mir-1256 Colorectal Neoplasms CONCLUSIONS: We firstly provided evidence that low miR-1256 expression was associated with the progression of CRC and could be used as a prognostic biomarker for breast cancer. +lncRNA target 30536310 hsa-mir-199b Carcinoma, Hepatocellular CONCLUSIONS: miR-199b exerted tumor suppressive functions in HCC by targeting JAG1, and it may be a potential target treatment for hepatocellular carcinoma. +transcription factor target 30536309 hsa-mir-144 Wilms Tumor 3p, which was up-regulated in pediatric WT, might inhibit the proliferation and metastasis of the cells by directly targeting Girdin. +genetics_overexpression_promote 30536308 hsa-mir-144 Prostatic Neoplasms, Castration-Resistant Overexpression of miR +genetics_overexpression_suppress 30536306 hsa-mir-1294 Carcinoma, Ovarian Epithelial Gain function assays showed that miR-1294 overexpression inhibited cell proliferation and cell cycle progression in EOC. +lncRNA target 30536304 hsa-mir-155 Osteosarcoma CONCLUSIONS MiR-155 affected osteosarcoma cell proliferation and apoptosis through regulating NF-B signaling pathway, indicating it might be a new biomarker for osteosarcoma diagnosis and treatment. +lncRNA target 30536131 hsa-mir-184 Fibrosis, Renal Here, we found miRNA-184 as a critical mediator to promote the renal fibrosis by targeting HIF1AN. Thus, miRNA-184 is an important agent to promote the fibrosis though binding to HIF1AN, and may be a promising novel target in treatment of renal fibrosis. +transcription factor target 30535663 hsa-mir-15b Cardiotoxicity In this study, we focused on the role of miR-15b-5p in DOX-induced cardiotoxicity. Collectively, the results suggest that miR-15b-5p is likely involved in doxorubicin-induced cardiotoxicity via inhibiting Bmpr1a signaling in H9c2 cardiomyocytes. +genetics_overexpression_promote 30535507 hsa-mir-98 Hypopharyngeal Neoplasms Overexpression of miRNA98 increased the apoptotic rate, and inhibited cell growth and migration of hypopharyngeal carcinoma cells. +other 30535506 hsa-mir-506 Carcinoma, Non-Small-Cell Lung Collectively, the results of the present study suggested that the downregulation of miR5063p contributes to gefitinib resistance, and thus, the restoration of miR5063p may be a potential therapeutic approach for overcoming NSCLC gefitinib resistance. +lncRNA target 30535503 hsa-mir-126 Adenocarcinoma of Lung However, no study of LUAD has researched the synergistic effects and cotargets of both miRNA1263p and miRNA1265p. +genetics_overexpression_promote 30535502 hsa-mir-143 Squamous Cell Carcinoma of Head and Neck In addition, it was verified that the oncogene kRas is a target of miR1433p in LSCC cells, and the suppressive effects of miR1433p on LSCC cells were abrogated by the overexpression of kRas. +genetics_knock down_promote 30535501 hsa-mir-223 Carcinoma, Hepatocellular To conclude, miR223 expression is upregulated in sorafenibresistant HCC cells, and miR223 knockdown significantly enhances HCC cell sensitivity to sorafenib by increasing expression of the target gene, FBW7, suggesting that miR223 may be a new therapeutic target for overcoming sorafenib resistance. +lncRNA target 30535497 hsa-mir-424 Carcinoma, Hepatocellular In a regulatory network centered on miRNA424, six mRNA target genes were associated with HCC survival rates. +epigenetics 30535495 hsa-mir-128 Esophageal Neoplasms Furthermore, the relative expression level of miR128 was negatively associated with COX2 in ESCC tissues. Collectively, these findings indicate that methylationassociated silencing of miR128 promotes the development of esophageal cancer through upregulation of the expression of cyclin D1 and Rb by targeting COX2 in ZD regions with a high incidence of esophageal cancer. +lncRNA target 30535489 hsa-mir-363 Liver Neoplasms miR3633p was identified as an important tumor suppressor in liver cancer via targeting HMGA2, which may have potential benefits in liver cancer therapy. +lncRNA target 30535480 hsa-mir-95 Stomach Neoplasms Therefore, miR-95 may be used as a novel therapeutic target for suppressing gastric cancer growth and metastasis. +lncRNA target 30535475 hsa-mir-1243p Community-Acquired Pneumonia Taken together, these results strongly indicated that miR1243p targeted the 3'UTR of TRAF6, while it attenuated SCAP by reducing LPSinduced inflammatory cytokine production and inhibiting the activation of p38 MAPK and NFkappaB signaling pathways. These findings indicate the immunoregulatory role of miR1243p against macrophagemediated SCAP. +other 30535472 hsa-mir-138 Stomach Neoplasms In the present study, the expression and regulatory mechanisms of miR1385p were investigated in the gastric cancer cell line SGC7901 and its cisplatinresistant derivative SGC7901/DDP. Taken together, these data suggest that miR1385p regulates the sensitivity of gastric cancer cells to cisplatin, possibly by modulating expression of the DNA repair proteins ERCC1 and ERCC4. +lncRNA target 30535468 hsa-mir-146a Gastritis These data suggested that miR146a may serve as a biomarker or therapeutic target in gastritis therapy. +circulation_biomarker_diagnosis_ns 30535467 hsa-mir-29c Pulmonary Arterial Hypertension Our previous studies identified that the expression of microRNA29c (miR29c3p) was significantly increased in the serum of pregnant women carrying fetuses with congenital heart disease (CHD) compared with in that of normal pregnant women. miR29c3p may be a potential therapeutic target for the treatment of CHD. +genetics_overexpression_promote 30535466 hsa-mir-23 Cerebral Infarction In addition, overexpression of miR323 directly targeted and suppressed SMAD3 expression in the in vitro model of cerebral infarction, while inhibition of miR323 induced SMAD3 expression. +lncRNA target 30535463 hsa-mir-145 Esophageal Squamous Cell Carcinoma In ESCC cells, 30 possible oncogenic targets were identified that might be regulated by miR1453p. +genetics_overexpression_suppress 30535450 hsa-mir-29a Carcinoma, Non-Small-Cell Lung Results from the present study revealed that miR29a overexpression enhanced and miR29a inhibition reduced the sensitivity of two NSCLC cell lines, A549 and H1650, to cisplatin treatment. +lncRNA target 30535441 hsa-mir-17 Carcinoma, Non-Small-Cell Lung The influence of miR175p on different NSCLC cell lines A549 and PC9 were also examined in vitro using miR175p mimics and inhibitors. The present study provides evidence for lincRNAp21 to inhibit the progression of NSCLC via direct targeting of a miR175p associated signaling pathway. +circulation_biomarker_diagnosis_ns 30535438 hsa-mir-27a Femur Head Necrosis The results indicated that serum miR27a was decreased in a rat model of ONFH compared with that in control rats. +genetics_overexpression_promote 30535437 hsa-mir-124 Lymphangioleiomyomatosis In the present study, it was revealed that miR124 was downregulated in LAM specimens and overexpression of miR124 resulted in the apoptosis of TSC2deficient cells via RXRalpha (retinoid X receptor alpha), while slightly influencing TSC2 wildtype cells. +other 30535435 hsa-mir-100 Ovarian Diseases In addition, miR1005p may serve an important role in protecting against OVXinduced osteoporosis. +other 30535431 hsa-mir-199a Uterine Cervical Neoplasms The present results suggest that DLX6AS1 acting as a sponge for miR199a may serve a critical role in the development and progression of cervical cancer. +transcription factor target 30535384 hsa-mir-454 Liver Cirrhosis MiR-454 can inhibit the activation and proliferation of HSCs via suppressing the expression of Wnt10a, to restrain liver cirrhosis. +transcription factor target 30534000 hsa-mir-344a Neurilemmoma CONCLUSIONS: Our findings demonstrate that curcumin induces apoptosis in schwannoma cells via miRNA 344a-3p. +lncRNA target 30531836 hsa-mir-126 Colorectal Neoplasms 5p axis could control angiogenesis and epithelial-mesenchymal transition in CRC, providing potential biomarkers and therapeutic targets for CRC. +circRNA target 30531834 hsa-mir-193a Prostatic Neoplasms Accordingly, dysregulation of the circAMOTL1L-miR-193a-5p-Pcdha8 regulatory pathway mediated by circAMOTL1L downregulation contributes to PCa growth in vivo. +genetics_overexpression_promote 30531691 hsa-let-7a Thyroid Cancer, Papillary CCK-8 and Transwell assays were performed to evaluate PTC cell proliferation, migration, and invasion in cells in which the expression of Lin28A was downregulated by RNA interference or in which let-7a was overexpressed after transfection with let-7a mimics. +genetics_overexpression_promote 30531691 hsa-let-7 Thyroid Cancer, Papillary CCK-8 and Transwell assays were performed to evaluate PTC cell proliferation, migration, and invasion in cells in which the expression of Lin28A was downregulated by RNA interference or in which let-7a was overexpressed after transfection with let-7a mimics. +lncRNA target 30530967 hsa-mir-539 Wilms Tumor CONCLUSION: MiR-539 inhibited the progression of WT through downregulation of JAG1 and Notch1/3. +circulation_biomarker_prognosis_ns 30530966 hsa-mir-100 Glioblastoma CONCLUSIONS: Our findings suggested that serum miR-100 might serve as promising biomarker for GBM diagnosis and prognosis. +lncRNA target 30530918 hsa-mir-203 Colonic Neoplasms In vivo study revealed that B3GALT5-AS1 suppressed colon cancer liver metastasis via its binding on miR-203 promoter and the repression of miR-203. +genetics_GWAS 30530815 hsa-mir-192 Carcinoma, Hepatocellular This study reveals the circuit from hypermethylation of the mir-192 promoter through the increase in PABPC4 as a shared genetic regulatory pathway in various groups of primary CSC(+) HCC. +lncRNA target 30530570 hsa-mir-1296 Stomach Neoplasms Our results indicated a tumor-suppressive role of miR +lncRNA target 30530288 hsa-let-7e Thyroid Cancer, Papillary miR-let-7e might function as a tumor suppressor in papillary thyroid carcinoma through HMGB1. Therefore, our study demonstrates that miR-let-7e plays an important role in papillary thyroid carcinoma progression and might represent a new potential therapeutic target for treatment. +lncRNA target 30530166 hsa-mir-155 Inflammatory Bowel Diseases Moreover, CA decreased the pro-inflammatory cytokines and NLRP3 inflammasome, miR-21 and miR-155 in colon tissues, in addition, the percentage of macrophages was reduced based on the surface marker F4/80 and IL-10 secretion in CA-treated group, suggesting that the CA ameliorate the UC via activation of macrophage. +lncRNA target 30530166 hsa-mir-21 Inflammatory Bowel Diseases Moreover, CA decreased the pro-inflammatory cytokines and NLRP3 inflammasome, miR-21 and miR-155 in colon tissues, in addition, the percentage of macrophages was reduced based on the surface marker F4/80 and IL-10 secretion in CA-treated group, suggesting that the CA ameliorate the UC via activation of macrophage. +transcription factor target 30530045 hsa-mir-1 Heart Failure, Chronic Therefore, we verified that SUR2B/Kir6.1 channel openers could correct endothelial imbalance and ameliorate chronic heart failure through the miR +epigenetics 30529831 hsa-mir-23b Atherosclerosis Among the known atherosclerosis- and contractile SMC-related genes that exhibited hypermethylated DMRs at aorta enhancer chromatin were ACTA2 (aorta alpha2 smooth muscle actin), ELN (elastin), MYOCD (myocardin), C9orf3 (miR-23b and miR-27b host gene), and MYH11 (smooth muscle myosin). +transcription factor target 30529807 hsa-mir-29b Pulmonary Fibrosis Together, our results clearly demonstrated that miR-29b acted as a novel negative regulator of silicosis fibrosis-inhibited lung fibrosis, probably by promoting MET and by suppressing EMT in the lung. +genetics_knock down_suppress 30529346 hsa-mir-34a Inflammation MEG3 overexpression and miR-34a knockdown could inhibit HG-induced apoptosis and secretion of inflammation cytokines including IL-1beta, IL-6 and TNF-alpha, but miR-34a overexpression alleviated such effects of MEG3. CONCLUSION: MEG3 could alleviate HG-inducing apoptosis and inflammation via inhibiting NF-kappaB signaling pathway by targeting miR-34a/SIRT1 axis. +genetics_overexpression_promote 30529155 hsa-mir-371 Stomach Neoplasms The in vitro functional assays demonstrated that overexpression of miR +circulation_biomarker_diagnosis_ns 30529132 hsa-mir-1290 Enterocolitis, Necrotizing CONCLUSIONS Plasma miR-1290 is a novel and specific biomarker that can effectively differentiate NEC cases from neonatal sepsis. +genetics_overexpression_suppress 30529043 hsa-mir-204 Osteosarcoma Additionally, EBF2 overexpression rescued the phenotype caused by miR +transcription factor target 30528902 hsa-mir-124 Hepatitis C Interestingly, miR-124 inhibits the production of hepatitis C virus, a virus that hijacks lipid pathways during its life cycle. +other 30528902 hsa-mir-124 Carcinoma, Hepatocellular This study advances our knowledge of the role of miR-124 in human hepatoma cells. Overall, our data highlight miR-124 as a novel regulator of TG metabolism in human hepatoma cells. +other 30528775 hsa-mir-219 Fragile X Syndrome SIGNIFICANCE: Our results suggest that miR-219 regulates dFMR1 expression in Drosophila and is involved in fragile X syndrome pathogenesis. +lncRNA target 30528736 hsa-mir-326 Adenocarcinoma of Lung In summary, this present study revealed that circPUM1 functions as an oncogene to promote the tumorigenesis of lung adenocarcinoma through circPUM1/miR-326/Cyclin D1 and Bcl-2 axis. +lncRNA target 30528264 hsa-mir-183 Lung Neoplasms 5p may function as a tumor suppressor in lung cancer via the miR +lncRNA target 30528230 hsa-mir-126 Carcinoma, Non-Small-Cell Lung In conclusion, results suggest that the MINCR-miRSLC7A5 axis plays an important role in the progression of NSCLC and may serve as a potential target for lung cancer diagnosis and treatment. +other 30527798 hsa-let-7 Prostatic Neoplasms TTTY15 promoted PCa by sponging the microRNA let-7, consequently increasing CDK6 and FN1 expression. CONCLUSIONS The Y-chromosomal lncRNA TTTY15 was upregulated in most PCa tissues and could promote PCa progression by sponging let-7. +genetics_overexpression_promote 30527681 hsa-mir-6807 Glioma Furthermore, overexpression of DACH1 rescued the promotive effects of miR +lncRNA target 30526546 hsa-mir-99a Retinoblastoma The anti-tumor activities of curcumin on Rb cells appeared to be via up-regulation of miR-99a, and thereby inhibition of JAK/STAT pathway. +exosome 30526325 hsa-mir-135b Osteoarthritis In rat experiments, OARSI score was decreased and the number of chondrocytes was increased in OA+TGF-beta1+MSC-exosome group, while the score and the number had an opposite trend in OA+TGF-beta1+MSC-miR135b inhibitor-exosome group. +other 30526087 hsa-mir-15a Carcinoma, Hepatocellular A methoxylated quercetin glycoside harnesses HCC tumor progression in a TP53/miR-15/miR-16 dependent manner. droserifolia in harnessing HCC progression in-vitro with a possible contribution of TP53/miR-15a/miR-16. +other 30526087 hsa-mir-16 Carcinoma, Hepatocellular A methoxylated quercetin glycoside harnesses HCC tumor progression in a TP53/miR-15/miR-16 dependent manner. droserifolia in harnessing HCC progression in-vitro with a possible contribution of TP53/miR-15a/miR-16. +other 30526087 hsa-mir-15 Carcinoma, Hepatocellular A methoxylated quercetin glycoside harnesses HCC tumor progression in a TP53/miR-15/miR-16 dependent manner. droserifolia in harnessing HCC progression in-vitro with a possible contribution of TP53/miR-15a/miR-16. +other 30526004 hsa-mir-4885 Esophageal Neoplasms Novel-miR-4885 can bind to 3' untranslated region of CTNNA2 to reduce cell adhesion and promote epithelial-mesenchymal transition in esophageal cancer cell. +genetics_overexpression_suppress 30525231 hsa-mir-153 Breast Neoplasms miR-153 overexpression in breast cancer cells was achieved by miR-153 mimic transfection. +genetics_overexpression_suppress 30525214 hsa-mir-505 Stomach Neoplasms Overexpression of miR-505 was able to repress GC progression in AGS and BGC-823 cells. +lncRNA target 30525209 hsa-mir-145 Carcinoma, Non-Small-Cell Lung Therefore, miR-145 is an important molecule in NSCLC that regulates cancer EMT through targeting ZEB2. +other 30525087 hsa-mir-125b Carcinoma, Pancreatic Ductal We identified that transforming growth factor-beta (TGF-beta) induces long non-coding RNA (lncRNA) MIR100HG along with its host microRNAs (miRNAs) miR-100 and miR-125b, to regulate its response in pancreatic ductal adenocarcinoma (PDAC). +lncRNA target 30525087 hsa-mir-100 Carcinoma, Pancreatic Ductal We identified that transforming growth factor-beta (TGF-beta) induces long non-coding RNA (lncRNA) MIR100HG along with its host microRNAs (miRNAs) miR-100 and miR-125b, to regulate its response in pancreatic ductal adenocarcinoma (PDAC). A novel method for global miRNA-target discovery identified that miR-100/125b regulates crucial PDAC pathways. +lncRNA target 30524906 hsa-mir-17 high grade glioma 5p-CXCL14 axis in regulating key steps of anti-tumor immune process and may serve as potential targets of immune treatments for gliomas. +other 30524889 hsa-mir-142 Precancerous Conditions A multivariate analysis revealed that decreased miRNA5p expression (P = 0.0484) and lower T-cell, monocytic and myeloid dendritic cells (MDC) immune infiltration (T-cells, P = 0.0196; CD8 T cells, P = 0.0129; MDC, P = 0.0481; and monocytes, P = 0.0212) were associated with oral cancer development in the immunological subtype only. +transcription factor target 30524679 hsa-mir-454 Ataxia Neuropathy Spectrum CONCLUSION: Pioglitazone protected H9c2 cells against OGD-induced injury through up-regulating miR-454, indicating a novel therapeutic strategy for treatment of MIRI. +transcription factor target 30524679 hsa-mir-454 Osteochondritis Dissecans MiR-454 suppression declined the protective effect of pioglitazone on OGD-injured H9c2 cells (P<0.05 or P< 0.01). +transcription factor target 30524425 hsa-mir-484 Peste-des-Petits-Ruminants 5p and miR-484 to their target thus establishing specific binding of the miRNAs to their targets.This is the first report on the miRNAome and proteome of virulent PPRV infected goat PBMCs. +exosome 30524227 hsa-mir-133b Spinal Cord Injuries In summary, these findings demonstrated that systemically injecting miR-133b exosomes preserved neurons, promoted the regeneration of axons, and improved the recovery of hindlimb locomotor function following SCI, suggesting that the transfer of exosome-mediated miRNAs represents a novel therapeutic approach for the treatment of SCI. +other 30524205 hsa-mir-218 Uterine Cervical Neoplasms The expression of miR5p was lower but LYN was higher in CC primary tumors compared with normal control. +genetics_overexpression_promote 30524203 hsa-mir-770 Glioma Importantly, CDK8 silencing recapitulated the cellular and molecular effects observed upon miR-770 overexpression, and CDK8 overexpression eliminated the effects of miR-770 overexpression on glioma cells. +transcription factor target 30523991 hsa-mir-101 Uterine Cervical Neoplasms Our results showed that CSP3 is a cervical cancer targeting 12aa peptide with high specificity and sensitivity, and the CSP3 conjugated drug delivery system, CSP3-Lipo-DOX-miR101 has promising potential for development as an efficient drug system for the therapy of cervical cancer. +other 30523707 hsa-mir-193b Dermatomyositis Among them, the expression levels of miR-196a-5p and CPM were negatively correlated in PM, miR-193b-3p and NECAP2 were negatively correlated in DM and PM. +other 30523707 hsa-mir-196a Polymyositis Among them, the expression levels of miR-196a-5p and CPM were negatively correlated in PM, miR-193b-3p and NECAP2 were negatively correlated in DM and PM. +other 30523707 hsa-mir-196a Dermatomyositis Among them, the expression levels of miR-196a-5p and CPM were negatively correlated in PM, miR-193b-3p and NECAP2 were negatively correlated in DM and PM. +other 30523707 hsa-mir-193b Polymyositis Among them, the expression levels of miR-196a-5p and CPM were negatively correlated in PM, miR-193b-3p and NECAP2 were negatively correlated in DM and PM. +lncRNA target 30523640 hsa-mir-137 Carcinoma, Hepatocellular The expressions of miR-137 and its liver microenvironment regulatory target gene AFM in combination significantly correlated with HCC progression in a higher number of patients than in previous studies, which suggested their potential as prognostic biomarkers for HCC. +lncRNA target 30523602 hsa-mir-374a Osteosarcoma In addition, the inhibition of WIF-1 abolished the miR-374a inhibitor-induced migration suppression of OS cells. +circulation_biomarker_diagnosis_ns 30523241 hsa-mir-133a Heart Failure Here, circulating miR-133a and miR-221 were investigated as potential diagnostic biomarkers for heart failure (HF) patients, particularly in elderly patients. +circulation_biomarker_diagnosis_ns 30523241 hsa-mir-221 Heart Failure Here, circulating miR-133a and miR-221 were investigated as potential diagnostic biomarkers for heart failure (HF) patients, particularly in elderly patients. +circulation_biomarker_diagnosis_ns 30523223 hsa-mir-183 Esophageal Squamous Cell Carcinoma When combined detection of serum miR-183 and CEA was used to diagnose ESCC, the sensitivity, specificity, AUC and 95% confidence interval was 82.3%, 92.6%, 0.877 and 0.814-0.935, respectively. +transcription factor target 30523220 hsa-mir-433 Colorectal Neoplasms Collectively, our study demonstrated the CREB1/miR-433 reciprocal feedback loop restrained the propagation, invasion and metastasis activities of CRC cells through abrogation of cell cycle progression and constraint of EMT. +lncRNA target 30522853 hsa-mir-93 Carcinoma, Hepatocellular The miR5p/PDCD4 pathway mediated the suppressing role of LINC00472 in HCC cells. +lncRNA target 30522554 hsa-mir-217 Osteosarcoma By bioinformatic analysis, we found that miR-217 targeted the SET Domain-Containing Protein 8 (SETD8), and there was a negative correlation between them in OS tissues. +lncRNA target 30522118 hsa-mir-376a Stomach Neoplasms CONCLUSION The results suggest that miR-376a could play an important role in the tumorigenesis and progression of GC and act as a novel therapeutic target and prognostic indicator in patients with GC. +lncRNA target 30522116 hsa-mir-183 Carcinoma, Hepatocellular CONCLUSION: Our results reveal a novel post-transcriptional regulatory mechanism for MTA1 expression via miR-183, which is suppressed during HCC pathogenesis. +lncRNA target 30522114 hsa-mir-661 Stomach Neoplasms Gastric Adenocarcinoma Predictive Long Intergenic Non-Coding RNA Promotes Tumor Occurrence and Progression in Non-Small Cell Lung Cancer via Regulation of the miR-661/eEF2K Signaling Pathway. CONCLUSION Our findings indicate that GAPLINC promotes NSCLC tumorigenesis by regulating miR-661/eEF2K cascade and provide new insights for the pathogenesis underlying NSCLC and potential targets for therapeutic strategy. +lncRNA target 30522114 hsa-mir-661 Carcinoma, Non-Small-Cell Lung Gastric Adenocarcinoma Predictive Long Intergenic Non-Coding RNA Promotes Tumor Occurrence and Progression in Non-Small Cell Lung Cancer via Regulation of the miR-661/eEF2K Signaling Pathway. CONCLUSION Our findings indicate that GAPLINC promotes NSCLC tumorigenesis by regulating miR-661/eEF2K cascade and provide new insights for the pathogenesis underlying NSCLC and potential targets for therapeutic strategy. +genetics_overexpression_suppress 30522111 hsa-mir-122 Colorectal Neoplasms Our results showed that the downregulation of miR-122 was responsible for the overexpression of XIAP in these oxaliplatin-resistant CRC cells. +genetics_overexpression_promote 30522099 hsa-mir-202 Carcinoma, Non-Small-Cell Lung Mechanically, as the Ras/mitogen-activated protein kinase (MAPK) pathway was aberrantly activated in NCI-H441 and A549 NSCLC cells, the overexpression of miR-202 was found to inhibit the Ras/MAPK pathway by targeting the KRas gene. +genetics_knock down_suppress 30522015 hsa-mir-26a Breast Neoplasms MiR-26a-5p overexpression significantly enhanced the effect of SNHG6 knockdown on the cell behaviors in BC. Therefore, our study may reveal a novel SNHG6/miR-26a-5p/MAPK6 pathway regulatory axis in BC pathogenesis. +genetics_overexpression_promote 30521964 hsa-mir-125b Inflammation Overexpression of THRIL promoted LPS-induced ATDC5 cell inflammatory injury by down-regulating miR-125b and then activating JAK1/STAT3 and NF-B pathways. +genetics_knock down_promote 30521861 hsa-mir-15b Condylar Hyperplasia Overexpression of miR-15b in CH chondrocytes suppressed the expression of IGF1, IGF1R and BCL2, while it increased when miR-15b was knockdown. +genetics_overexpression_promote 30521783 hsa-mir-19a Stomach Neoplasms Finally, overexpression of miR-19a caused inhibition of the xenografted tumors in vivo indicating the potential of miR-19a as therapeutic target for gastric cancer. +other 30521500 hsa-mir-134 Carcinoma, Ovarian Epithelial CONCLUSIONS LINC01118 acted as an oncogene and modulated EOC paclitaxel sensitivity by regulating miR-134/ABCC1. +genetics_overexpression_promote 30521471 hsa-mir-107 Colorectal Neoplasms LncRNA TINCR overexpression exerted suppressive influence on CRC progression through modulating the PPAR signaling pathway via the miR-107/CD36 axis. +genetics_overexpression_promote 30521417 hsa-mir-942 Breast Neoplasms In conclusion, TCDD induced circ_0001098 overexpression and then suppressed breast cancer tumorigenesis via miR +epigenetics 30521373 hsa-mir-129 Carcinoma, Hepatocellular Restoring methylation potential in LC cortical NPCs led to the re-establishment of normal miR +genetics_overexpression_promote 30521133 hsa-mir-520e Carcinoma, Hepatocellular We find that MiR-520e was decreased in HBV-positive HCC, while overexpression of miR-520e blocked p38MAPK and ERK1/2 signalling pathways by an inhibitory effect on EphA2 and ultimately reduced HBV replication and inhibited tumour cell growth. +other 30521085 hsa-mir-146a Obesity The present study aimed to investigate the role of microRNA-146a and its adapter proteins [interleukin-1 receptor-associated kinase 1 (IRAK1) and tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6)] in the pathogenesis of ovalbumin (OVA)-sensitized rats in association with the diet-induced obesity condition. These results suggest that a defect in the NF-kB-miR-146a negative feedback loop may be involved in the pathogenesis of obesity associated with OVA-sensitized condition. +other 30521014 hsa-mir-196a Kidney Diseases CONCLUSIONS: Increased urinary miR-196a was significantly associated with the progression of renal injury and might be a noninvasive prognostic marker of renal fibrosis in DN patients. +other 30521014 hsa-mir-196a Diabetic Nephropathies CONCLUSIONS: Increased urinary miR-196a was significantly associated with the progression of renal injury and might be a noninvasive prognostic marker of renal fibrosis in DN patients. +other 30520539 hsa-mir-761 Carcinoma, Hepatocellular Further mechanistic studies showed that circLARP4 dampened HCC progression by sponging miR-761, thereby promoting the expression level of RUNX3 and activating the downstream p53/p21 signaling. Our study revealed the role of circLARP4/miR-761/RUNX3/p53/p21 signaling in HCC progression, providing a potential survival predictor and therapeutic candidate for HCC. +genetics_overexpression_promote 30520388 hsa-mir-342 Breast Neoplasms 5p overexpression in HER2 positive BC cell lines elicits broad effects on HER2 downstream signaling, cell motility and mitochondrial stability. +circRNA target 30520151 hsa-mir-7 Breast Neoplasms 5p/Raf1/MEK/ERK regulatory network in the development of breast cancer and suggests that circ_0006528 is a potential therapeutic target and prognostic predictor for breast cancer. +other 30520141 hsa-mir-185 Glioma 5p/CCND2 axis in the glioma development. +genetics_overexpression_promote 30520131 hsa-mir-21 Esophageal Squamous Cell Carcinoma lncRNA HAND2-AS1 overexpression resulted in downregulation of miRNA-21 in cells of ESCC cell lines and inhibited cell proliferation, migration, and invasion. +other 30520100 hsa-mir-106b Colonic Neoplasms Further analysis demonstrated that circ_0055625 might get involved in the pathogenesis of colon cancer by functioning as miRNA sponges and performed bioinformatics analysis of the predicted circ_0055625/miR-106b-5p (miR-106b)/ITGB8 network. These data indicated that circ_0055625/miR-106b/ITGB8 played a role in promoting tumor growth and metastasis, which suggested that circ_0055625 was a potential biomarker of colon cancer. +lncRNA target 30520099 hsa-mir-590 Breast Neoplasms 3p exerts tumor-suppressing effects through targeting SIRT1 in breast cancer cells, which makes it a potential therapeutic target for developing more efficient treatments for breast cancer. +transcription factor target 30520098 hsa-mir-202 Neuralgia These data suggested that miR-202 acted pivotal roles in the development of neuropathic pain partly through targeting RAP1A gene. +transcription factor target 30520097 hsa-mir-29a Diabetes Mellitus In short, our study demonstrates that hsa-miRNA-29a is a promising target for the prevention and treatment of vascular injury in diabetic patients. +transcription factor target 30520097 hsa-mir-29a Vascular System Injuries In short, our study demonstrates that hsa-miRNA-29a is a promising target for the prevention and treatment of vascular injury in diabetic patients. +genetics_knock down_promote 30520073 hsa-mir-495 Stomach Neoplasms Function assays confirmed that lncRNA SNHG20 knockdown using RNA interference suppressed cell proliferation and invasion of GC by negatively regulating miR +circulation_biomarker_diagnosis_up 30519780 hsa-mir-214 autosomal recessive congenital bilateral absence of vas deferens Results showed that the expression levels of TLR4, MyD88, NF-kappaB, and miR-214 were up-regulated in the blood and aortic valve tissue samples of patients with CAVD when compared with normal individuals. +other 30519661 hsa-mir-296 Essential Hypertension MicroRNA let-7e and microRNA 296-5p have been linked to different cardiovascular diseases. +circulation_biomarker_diagnosis_ns 30519661 hsa-let-7e Essential Hypertension This study aimed to determine association of serum miRNA let-7e and miRNA 296-5p with essential hypertension in Egyptian patients. Results from this study indicate that miRNA let-7e can potentially be a biomarker for essential hypertension. +transcription factor target 30519352 hsa-mir-34a Brain Stem Neoplasms Last, we found that hsa-miR-34a-5p inhibits BSG cell invasion in vitro. +transcription factor target 30519341 hsa-mir-532 Stomach Neoplasms 3p directly targets Rab3IP and represses its function, thereby demonstrating a novel regulatory link in GC. +other 30519318 hsa-mir-34a Osteosarcoma We should be more committed to investigate the clinical significance of miRNA-34a in osteosarcoma patients. +lncRNA target 30519044 hsa-mir-517a Carcinoma, Hepatocellular CONCLUSION: We demonstrated that miR-517a acts as an oncogene to promote Warburg effect in HCC, favoring tumor growth, and miR-517a/FBP1 could be a novel target for HCC treatment. +lncRNA target 30519038 hsa-mir-185 Sarcoma, Ewing Besides, upregulation of miR-185 was observed to accelerate cell apoptosis in a mitochondrial pathway through regulating Bcl-2/Bax, Caspase 3, and Caspase 9 in Ewing's sarcoma in vitro. +genetics_overexpression_promote 30519035 hsa-mir-18a Carcinoma, Hepatocellular Furthermore, overexpressing Bcl2L10 was able to partly reverse the promoting effects of miR-18a on HCC cell progression. +epigenetics 30518922 hsa-mir-125b Carcinoma, Non-Small-Cell Lung Here, we show that ectopic over-expression of FHC induces the promoter hypermethylation and the down-regulation of miR-125b that, in turn, enhances p53 protein expression in non-small cell lung cancer (NSCLC) cell lines. +lncRNA target 30518760 hsa-mir-637 Uterine Cervical Neoplasms Exogenous miR-637 and RING1 interventions could reverse the proliferation ability mediated by C5orf66-AS1 in cervical cancer cells. LncRNA C5orf66-AS1, as a competitive endogenous RNA (ceRNA), regulated the effect of RING1 on the proliferation, apoptosis and cell cycle of cervical cancer cells through adsorbing miR-637. +other 30518759 hsa-mir-4658 Colorectal Neoplasms The T>C variant of rs1317082 at CCSlnc362 exon 1 created a binding site for miR-4658 to reduce the expression of CCSlnc362 and thus decreased the susceptibility to CRC. +genetics_knock down_suppress 30518750 hsa-mir-627 Glioma Stable knockdown of lnc-UCA1 or overexpression of miR +lncRNA target 30518744 hsa-mir-29a Osteosarcoma Targeting the miR-29 family might provide new strategies to overcome the high-dosage MTX-induced cytotoxicity in osteosarcoma treatment. +other 30518697 hsa-mir-455 Acquired Immunodeficiency Syndrome 3p represents a potential biomarker for HIV-associated sDSP and might also exert pathogenic effects leading to sDSP. +other 30518697 hsa-mir-455 Nerve Degeneration 3p represents a potential biomarker for HIV-associated sDSP and might also exert pathogenic effects leading to sDSP. +other 30518666 hsa-mir-141 Prostatic Neoplasms Next, we quantified the extent of bias avoided in evaluating the association of Ki67 (immunohistochemistry), stromal cell telomere length (fluorescence in situ hybridization), and microRNA (miRNA) (miR-21, miR-141, miR-221; quantitative RT-PCR) with prostate cancer risk or recurrence in nested case-control studies. +other 30518666 hsa-mir-21 Prostatic Neoplasms Next, we quantified the extent of bias avoided in evaluating the association of Ki67 (immunohistochemistry), stromal cell telomere length (fluorescence in situ hybridization), and microRNA (miRNA) (miR-21, miR-141, miR-221; quantitative RT-PCR) with prostate cancer risk or recurrence in nested case-control studies. +other 30518666 hsa-mir-221 Prostatic Neoplasms Next, we quantified the extent of bias avoided in evaluating the association of Ki67 (immunohistochemistry), stromal cell telomere length (fluorescence in situ hybridization), and microRNA (miRNA) (miR-21, miR-141, miR-221; quantitative RT-PCR) with prostate cancer risk or recurrence in nested case-control studies. +lncRNA target 30518628 hsa-mir-21 Prostatic Neoplasms These results uncover miR-21 and PDCD4-regulated pathways as potential new targets for castration-resistant prostate cancer. +genetics_GWAS 30518189 hsa-mir-196a-2 Multiple Sclerosis This study was conducted to investigate the association between mir155 rs767649, mir196a2 rs11614913 and mir23a rs3745453 polymorphism and the risk of multiple sclerosis in the Iranian MS patients in Isfahan. Unlike mir155 and mir196a2, mir23a rs3745453 may have contributed to the etiology of MS in Isfahan patients. +genetics_GWAS 30518189 hsa-mir-155 Multiple Sclerosis This study was conducted to investigate the association between mir155 rs767649, mir196a2 rs11614913 and mir23a rs3745453 polymorphism and the risk of multiple sclerosis in the Iranian MS patients in Isfahan. Unlike mir155 and mir196a2, mir23a rs3745453 may have contributed to the etiology of MS in Isfahan patients. +genetics_GWAS 30518189 hsa-mir-23a Multiple Sclerosis This study was conducted to investigate the association between mir155 rs767649, mir196a2 rs11614913 and mir23a rs3745453 polymorphism and the risk of multiple sclerosis in the Iranian MS patients in Isfahan. Unlike mir155 and mir196a2, mir23a rs3745453 may have contributed to the etiology of MS in Isfahan patients. +circulation_biomarker_diagnosis_up 30518009 hsa-mir-21 Purpura 5p in peripheral blood B cells of patients with HSP is one of the reasons for the reduction of IL-10 expression in B cells. +genetics_knock down_suppress 30516071 hsa-mir-221 Leukemia, Myelogenous, Chronic, BCR-ABL Positive MiR-221 restoration and STAT5 knockdown in K562/G cells increased the sensitivity of CML cells to imatinib by reducing the Bcl2: Bax ratio. +other 30515804 hsa-let-7e Colorectal Neoplasms Consistent with this, we identified that increased levels of let-7e in CRC cells reduced IGF-1R protein level and subsequently its downstream signaling pathways, which resulted in the G1 cell cycle arrest and a significant reduction in the proliferation, survival and also resistance to radiation of CRC cells. +genetics_knock down_promote 30515803 hsa-mir-23b Stomach Neoplasms Furthermore, the overexpression of DGCR5 suppressed tumor growth, and inhibited the expression of miR-23b and proliferation antigen Ki-67, but increased the expression of PTEN and BTG1 in vivo. +transcription factor target 30515795 hsa-mir-129 Branchio-Oto-Renal Syndrome Inhibition of miR5p is able to increase the antioxidant capacity, EGFR-positive rate and the expressions of EGFR, B-cell lymphoma-2, zonula occluden-1, occludin, and keratinocyte growth factor-2, but decrease the expression of vascular endothelial growth factor, BCL2-associated X protein, interleukin (IL)-1beta, and IL-4. +lncRNA target 30515786 hsa-mir-429 Uterine Cervical Neoplasms Finally, in vivo animal models were established, and we indicated that MALAT1 inhibited cervical cancer progression via targeting miR-429. +lncRNA target 30515781 hsa-let-7a Glomerulonephritis, Membranous Interleukin 6 (IL6) and MYC messenger RNAs (mRNAs; targets of DE miRNAs) were significantly downregulated in biopsies from MGN patients, and upregulated in A498 cells following let-7a-5p or let-7c-5p transient silencing. +lncRNA target 30515781 hsa-let-7c Glomerulonephritis, Membranous Interleukin 6 (IL6) and MYC messenger RNAs (mRNAs; targets of DE miRNAs) were significantly downregulated in biopsies from MGN patients, and upregulated in A498 cells following let-7a-5p or let-7c-5p transient silencing. +genetics_GWAS 30515607 hsa-mir-34b Squamous Cell Carcinoma of Head and Neck HNSCC of the oral cavity also up-regulated miR-34b/b*/c while no such overexpression was observed in HNSCC of the larynx and hypopharynx. CONCLUSIONS Surgically resected HNSCC samples with no TP53 mutations have elevated levels of miR-34a and miR-34b/b*/c, while those with TP53 mutations show no such up-regulation. +genetics_overexpression_promote 30515607 hsa-mir-34 Squamous Cell Carcinoma of Head and Neck HNSCC of the oral cavity also up-regulated miR-34b/b*/c while no such overexpression was observed in HNSCC of the larynx and hypopharynx. +genetics_overexpression_promote 30515607 hsa-mir-34a Squamous Cell Carcinoma of Head and Neck HNSCC of the oral cavity also up-regulated miR-34b/b*/c while no such overexpression was observed in HNSCC of the larynx and hypopharynx. +other 30515297 hsa-mir-127 Lupus Erythematosus, Systemic miRNA TaqMan assays were performed to analyse the expression of 10 lupus-associated miRNAs including miR96-183 cluster, miR-146a, miR-148a, miR-21, miR-31, miR-127, miR-155, and miR-411 in MRL and MRL/lpr PBMCs. +other 30515297 hsa-mir-1 Lupus Erythematosus, Systemic miRNA TaqMan assays were performed to analyse the expression of 10 lupus-associated miRNAs including miR96-183 cluster, miR-146a, miR-148a, miR-21, miR-31, miR-127, miR-155, and miR-411 in MRL and MRL/lpr PBMCs. +other 30515297 hsa-mir-21 Lupus Erythematosus, Systemic miRNA TaqMan assays were performed to analyse the expression of 10 lupus-associated miRNAs including miR96-183 cluster, miR-146a, miR-148a, miR-21, miR-31, miR-127, miR-155, and miR-411 in MRL and MRL/lpr PBMCs. +other 30515297 hsa-mir-148a Lupus Erythematosus, Systemic miRNA TaqMan assays were performed to analyse the expression of 10 lupus-associated miRNAs including miR96-183 cluster, miR-146a, miR-148a, miR-21, miR-31, miR-127, miR-155, and miR-411 in MRL and MRL/lpr PBMCs. +other 30515297 hsa-mir-146a Lupus Erythematosus, Systemic miRNA TaqMan assays were performed to analyse the expression of 10 lupus-associated miRNAs including miR96-183 cluster, miR-146a, miR-148a, miR-21, miR-31, miR-127, miR-155, and miR-411 in MRL and MRL/lpr PBMCs. +other 30515297 hsa-mir-182 Lupus Erythematosus, Systemic miRNA TaqMan assays were performed to analyse the expression of 10 lupus-associated miRNAs including miR96-183 cluster, miR-146a, miR-148a, miR-21, miR-31, miR-127, miR-155, and miR-411 in MRL and MRL/lpr PBMCs. +other 30515297 hsa-mir-155 Lupus Erythematosus, Systemic miRNA TaqMan assays were performed to analyse the expression of 10 lupus-associated miRNAs including miR96-183 cluster, miR-146a, miR-148a, miR-21, miR-31, miR-127, miR-155, and miR-411 in MRL and MRL/lpr PBMCs. +other 30515297 hsa-mir-411 Lupus Erythematosus, Systemic miRNA TaqMan assays were performed to analyse the expression of 10 lupus-associated miRNAs including miR96-183 cluster, miR-146a, miR-148a, miR-21, miR-31, miR-127, miR-155, and miR-411 in MRL and MRL/lpr PBMCs. +other 30515297 hsa-mir-183 Lupus Erythematosus, Systemic miRNA TaqMan assays were performed to analyse the expression of 10 lupus-associated miRNAs including miR96-183 cluster, miR-146a, miR-148a, miR-21, miR-31, miR-127, miR-155, and miR-411 in MRL and MRL/lpr PBMCs. +other 30515265 hsa-mir-206 Osteosarcoma All together, our results suggest the absence of the miR-198 and -206 as powerful predictive biomarkers of the tumor cell dissemination and the rationale of their potential therapeutic use in the treatment of Osteosarcoma. +other 30515265 hsa-mir-198 Osteosarcoma All together, our results suggest the absence of the miR-198 and -206 as powerful predictive biomarkers of the tumor cell dissemination and the rationale of their potential therapeutic use in the treatment of Osteosarcoma. +other 30515165 hsa-mir-125b Down Syndrome Our data show that the expression of HSA21-encoded miR-155 and miR-125b is altered in B cells of DS individuals both in vivo and in vitro. +exosome 30515094 hsa-mir-223 Vascular System Injuries However, the relationship between monocytes-derived exosomal microRNA-223 and vascular inflammation injury along with paeonol' effects are still not clear. +transcription factor target 30514916 hsa-mir-335 Breast Neoplasms We demonstrate that iEVs-335 efficiently and durably restored the endogenous miR-335 pool in human triple negative breast cancer cells, downregulated the expression of the miR-335 target gene SOX4 transcription factor, and markedly inhibited tumor growth in vivo. +other 30514686 hsa-mir-122 Melanoma 5p expression is upregulated in melanoma tissues, indicating its involvement in the development of melanoma. +other 30514341 hsa-mir-194 Cholangiocarcinoma A combination of high-level TSPAN1 and low-level miR5p predicted poor prognosis in patients with CCA. +other 30514309 hsa-mir-375 Osteosarcoma METHODS: The effects of circFAT1/miR-375/YAP1 was evaluated on human osteosarcoma cells growth, apoptosis, migration, invasion and tumorigenesis. +exosome 30514242 hsa-mir-134 Ischemic Stroke CONCLUSIONS: The exosomal miR-134 as a possible novel biomarker for the diagnosis and prognosis of stroke. +other 30514198 hsa-mir-4647 Arthritis, Rheumatoid 3p. +other 30514198 hsa-mir-198 Arthritis, Rheumatoid 3p. +other 30514198 hsa-mir-7167 Arthritis, Rheumatoid 3p. +other 30513647 hsa-mir-29c Influenza, Human The conclusion is that alteration of intestinal flora induced by antibiotic interference affected the expression of pulmonary miRNAs to interfere with host antiviral immunity, of which miR-146b and miR-29c might be good resources of resistance to influenza under antibiotic abuse. +other 30513647 hsa-mir-146b Influenza, Human The conclusion is that alteration of intestinal flora induced by antibiotic interference affected the expression of pulmonary miRNAs to interfere with host antiviral immunity, of which miR-146b and miR-29c might be good resources of resistance to influenza under antibiotic abuse. +other 30513523 hsa-mir-15 Inflammatory Bowel Diseases MiR-15 levels were higher in UC patients than in IBS patients or healthy subjects. +genetics_overexpression_promote 30513512 hsa-mir-544a Spinal Cord Injuries Subsequently, miR-544a was overexpressed to observe changes in inflammation and grip strength after spinal cord injury. +other 30513418 hsa-mir-202 Osteoarthritis miR3p was upregulated in Sertoli cells of Sertoli cell-only syndrome (SCOS) patients compared with obstructive azoospermia (OA) patients with normal spermatogenesis. +other 30513418 hsa-mir-202 X-linked spermatogenic failure 1 miR3p was upregulated in Sertoli cells of Sertoli cell-only syndrome (SCOS) patients compared with obstructive azoospermia (OA) patients with normal spermatogenesis. +other 30513418 hsa-mir-202 Roberts Syndrome miR3p was upregulated in Sertoli cells of Sertoli cell-only syndrome (SCOS) patients compared with obstructive azoospermia (OA) patients with normal spermatogenesis. +other 30513418 hsa-mir-202 Aspermia miR3p was upregulated in Sertoli cells of Sertoli cell-only syndrome (SCOS) patients compared with obstructive azoospermia (OA) patients with normal spermatogenesis. +genetics_overexpression_suppress 30513336 hsa-mir-29 Ataxia Neuropathy Spectrum Furthermore, overexpression of miR-29 mitigated the formation of mutant alphaB-crystallin (R120G) protein aggregates. +other 30513336 hsa-mir-29 Eye Diseases These findings reveal a novel role of miR-29, which has the potential of being a therapeutic strategy for rescuing RPE degeneration in ocular disorders. +transcription factor target 30513336 hsa-mir-29 Macular Degeneration We previously found that miR-29 is downregulated in choroid/RPE tissue in a model of exudative age-related macular degeneration (AMD), suggesting that miR-29 deficiency may contribute to autophagy inhibition and AMD progression. +other 30513336 hsa-mir-29 Retinal Degeneration These findings reveal a novel role of miR-29, which has the potential of being a therapeutic strategy for rescuing RPE degeneration in ocular disorders. +genetics_knock down_promote 30513279 hsa-mir-20a Uterine Cervical Neoplasms Restoration experiments disclosed that THBS2 knockdown abrogated miR-20a inhibitor-mediated anti-proliferation, pro-apoptosis, and anti-autophagy effects in CC cells. +lncRNA target 30512998 hsa-mir-200b Tenon Fibroblasts BACKGROUND: To determine the involvement of MicroRNA-200b (miR-200b) in human Tenon's fibroblasts (HTFs) fibrosis. CONCLUSION: TGF-beta1-mediated miR-200b induces HTFs fibrosis through suppressing PTEN signaling pathway. +transcription factor target 30512964 hsa-mir-361 Telangiectasia, Hereditary Hemorrhagic 3p, known to target insulin-like growth factor 1 (IGF1), a potent angiogenic growth factor, were found to be significantly downregulated in HHT patients. +transcription factor target 30512964 hsa-mir-28 Telangiectasia, Hereditary Hemorrhagic 3p, known to target insulin-like growth factor 1 (IGF1), a potent angiogenic growth factor, were found to be significantly downregulated in HHT patients. +other 30511935 hsa-let-7f Glioblastoma Results There was a significant change in expression of miR-7, miR-9, miR-21, miR-26b, mirR-124a, miR-199a and let-7f in recurrent tumor compared to the primary. In recurrent tumor, miR-15b, let-7d and let-7f significantly changed comparing both treatment options. +lncRNA target 30511586 hsa-mir-144 Cerebral Hemorrhage 3p mimic and inhibitor both in vivo and in vitro. +lncRNA target 30511586 hsa-mir-144 Brain Injury, Chronic 3p mimic and inhibitor both in vivo and in vitro. +genetics_overexpression_promote 30511377 hsa-mir-4324 Urinary Bladder Neoplasms Our studies indicated that ectopic overexpression of miR-4324 in BCa cells significantly suppressed cell proliferation and metastasis and enhanced chemotherapy sensitivity to doxorubicin by repressing RACGAP1 expression. +circulation_biomarker_diagnosis_ns 30511295 hsa-mir-155 Arthritis, Rheumatoid 5p in peripheral blood. +circulation_biomarker_diagnosis_ns 30511295 hsa-mir-132 Arthritis, Rheumatoid 5p in peripheral blood. +circulation_biomarker_diagnosis_ns 30511295 hsa-mir-146a Arthritis, Rheumatoid 5p in peripheral blood. +lncRNA target 30510566 hsa-mir-205 Ovarian Neoplasms 5p contributes to cisplatin resistance in C13K ovarian cancer cells may via targeting PTEN/AKT pathway. +circulation_biomarker_prognosis_ns 30510490 hsa-mir-146a Acute Lung Injury OBJECTIVE: This study is aimed at examining the differential expression of miR-146a, miR-150, and cytokines (IL-6 and IL-10) between younger and elderly rats suffering from hip fracture and investigating the possible meaning of them in early diagnosis and prognosis of ALI after hip fracture. Serum miR-146a and miR-150 are potential biomarkers for diagnosis and prognosis of ALI after hip fracture. +circulation_biomarker_prognosis_ns 30510490 hsa-mir-146a Hip Fractures OBJECTIVE: This study is aimed at examining the differential expression of miR-146a, miR-150, and cytokines (IL-6 and IL-10) between younger and elderly rats suffering from hip fracture and investigating the possible meaning of them in early diagnosis and prognosis of ALI after hip fracture. Serum miR-146a and miR-150 are potential biomarkers for diagnosis and prognosis of ALI after hip fracture. +circulation_biomarker_prognosis_ns 30510490 hsa-mir-150 Acute Lung Injury OBJECTIVE: This study is aimed at examining the differential expression of miR-146a, miR-150, and cytokines (IL-6 and IL-10) between younger and elderly rats suffering from hip fracture and investigating the possible meaning of them in early diagnosis and prognosis of ALI after hip fracture. Serum miR-146a and miR-150 are potential biomarkers for diagnosis and prognosis of ALI after hip fracture. +circulation_biomarker_prognosis_ns 30510490 hsa-mir-150 Hip Fractures OBJECTIVE: This study is aimed at examining the differential expression of miR-146a, miR-150, and cytokines (IL-6 and IL-10) between younger and elderly rats suffering from hip fracture and investigating the possible meaning of them in early diagnosis and prognosis of ALI after hip fracture. Serum miR-146a and miR-150 are potential biomarkers for diagnosis and prognosis of ALI after hip fracture. +transcription factor target 30510452 hsa-mir-125a Colorectal Neoplasms Moreover, we verifed that miR-125a-5p suppressed CRC growth and metastasis in vivo. +other 30510209 hsa-mir-130a Esophageal Squamous Cell Carcinoma Therefore, the current study investigated the role of different expression levels of miR-130a-3p and miR-148a-3p on drug resistance and tumor biology in four esophageal squamous cell carcinoma cell lines. +other 30510209 hsa-mir-148a Esophageal Squamous Cell Carcinoma Therefore, the current study investigated the role of different expression levels of miR-130a-3p and miR-148a-3p on drug resistance and tumor biology in four esophageal squamous cell carcinoma cell lines. +other 30510148 hsa-mir-153 Carcinoma, Hepatocellular 5p/ARHGAP18 signaling. +other 30509491 hsa-mir-1183 Carcinoma, Non-Small-Cell Lung In conclusion, circ_0016760/miR-1183/PDPK1 signaling pathway might play vital roles in the tumorigenesis of NSCLC. +lncRNA target 30509104 hsa-mir-203a Urinary Bladder Neoplasms In summary, our study determined that miR-203a down-regulation is closely related to tumorigenesis in bladder cancer; thus suggesting that miR-203a is a potential prognostic marker and a potential target in bladder cancer treatment. +other 30509103 hsa-mir-107 Colorectal Neoplasms Recent studies have also demonstrated that microRNA-107 (miR-107) and tropomyosin alpha-1 (TPM1) are important regulators of cancer cell proliferation, but it remains unclear if these are involved in regulating the effect of Skullcapflavone I on CRC cells. This study therefore assessed the effects of Skullcapflavone I on CRC cell proliferation and investigated miR-107 and TPM1 regulatory effects on this process. +lncRNA target 30509089 hsa-let-7a Breast Neoplasms These combined results confirm that let-7a functions as a tumor suppressor by targeting MAGE-A1 in breast cancer and it therefore provides a novel target in breast cancer clinical treatment. +other 30509082 hsa-mir-495 Colorectal Neoplasms 3p, hsa-miR-495, and hsa-miR-320d may be used as sensitive biomarkers in CRC patients. +other 30509082 hsa-mir-320d Colorectal Neoplasms 3p, hsa-miR-495, and hsa-miR-320d may be used as sensitive biomarkers in CRC patients. +other 30509082 hsa-mir-590 Colorectal Neoplasms 3p, hsa-miR-495, and hsa-miR-320d may be used as sensitive biomarkers in CRC patients. +circulation_biomarker_diagnosis_up 30509037 hsa-mir-21 Astrocytoma Here we show that rapamycin treatment leads to the upregulation of miR-21 in both patients' serum and in primary SEGA tumor cells in the culture indicating the regulatory relationship between rapamycin treatment and miR-21 expression. +circulation_biomarker_diagnosis_up 30509037 hsa-mir-21 Tuberous Sclerosis 1 Here we show that rapamycin treatment leads to the upregulation of miR-21 in both patients' serum and in primary SEGA tumor cells in the culture indicating the regulatory relationship between rapamycin treatment and miR-21 expression. +lncRNA target 30508543 hsa-mir-624 Esophageal Squamous Cell Carcinoma Our findings showed that circVRK1 suppressed ESCC progression by regulating miR +genetics_knock down_promote 30508510 hsa-mir-135b Stomach Neoplasms We identified FOXN3 and RECK messenger RNAs (mRNAs) as targets of miR-135B; their knockdown reduced migration of gastric cancer cell lines. +other 30507304 hsa-mir-103 Urinary Bladder Neoplasms METHODS: miR-141, miR-10b, miR-34b and miR-103 were selected to assess their expression in urine samples of 66 bladder cancer patients and 53 matched controls using quantitative real time PCR. +other 30507304 hsa-mir-141 Urinary Bladder Neoplasms METHODS: miR-141, miR-10b, miR-34b and miR-103 were selected to assess their expression in urine samples of 66 bladder cancer patients and 53 matched controls using quantitative real time PCR. +other 30507304 hsa-mir-34b Urinary Bladder Neoplasms METHODS: miR-141, miR-10b, miR-34b and miR-103 were selected to assess their expression in urine samples of 66 bladder cancer patients and 53 matched controls using quantitative real time PCR. +other 30507304 hsa-mir-10b Urinary Bladder Neoplasms METHODS: miR-141, miR-10b, miR-34b and miR-103 were selected to assess their expression in urine samples of 66 bladder cancer patients and 53 matched controls using quantitative real time PCR. +genetics_overexpression_promote 30507050 hsa-mir-30 Carcinoma, Non-Small-Cell Lung The overexpression of circ_0078767 and RASSF1A or the underexpression of miR +genetics_knock down_promote 30507047 hsa-mir-223 Pulmonary Arterial Hypertension 3p overexpression and ITGB3 knockdown alleviated the pulmonary vascular remodelling and improved the PAH pathological features of rats. +other 30506995 hsa-let-7a Embryo Loss The expression of ErbB4, Itg-beta3, Itg-alphav, TGF-alpha transcripts, and miR-Let-7a in blastocysts biopsied embryos did not differ from the non-biopsied blastocysts (P > 0.05). +genetics_overexpression_promote 30506990 hsa-mir-200b Diabetic Cardiomyopathies RESULTS: miR-200b-3p was low-expressed while CD36 was overexpressed in DCM. +genetics_overexpression_promote 30506984 hsa-mir-107 Breast Neoplasms In MDA-MB-231 and MDA-MB-453 breast cancer cells, the expression of p62, Beclin1 protein, and the changes of cell proliferation and migration after overexpression of m miR-107 were detected by Western blotting, 3-(4,5-dimethylthiazol +lncRNA target 30506951 hsa-mir-181a Glioma In summary, our study sheds light on the regulatory mechanism of hsa_circ_0076248 in glioma growth and invasion via sponging miR-181a, which downregulates the SIRT1 expression and also suggests that hsa_circ_0076248, miR-181a, and SIRT1 may serve as potential therapeutic targets for glioma. +transcription factor target 30506950 hsa-mir-543 Osteoporosis Our findings revealed that inhibition of miRNA-543 could protect osteoblasts against ovariectomy-induced osteoporosis through AKT/p38 MAPK signaling pathway by targeting YAF2. +other 30506923 hsa-mir-186 Diabetic Cardiomyopathies Collectively, miR5p attenuated HG-induced apoptosis by regulating TLR3 in cardiomyocytes, providing novel biomarker for treatment of diabetic cardiomyopathy. +other 30506863 hsa-mir-2909 Mitochondrial Diseases Based upon such a study, we hypothesize that mitochondrial dysfunction observed in melanomas may result from deregulated miR-2909 expression within such cells. +genetics_overexpression_promote 30506863 hsa-mir-2909 Melanoma Our present study stemmed from the observation that human A-375 and melanoma B16 cells displayed overexpression of a novel micro-RNA, miR-2909, shown in our earlier studies to be involved in aerobic glycolysis. Based upon such a study, we hypothesize that mitochondrial dysfunction observed in melanomas may result from deregulated miR-2909 expression within such cells. +lncRNA target 30506733 hsa-mir-1 Cleidocranial Dysplasia The application of miR-31 inhibitor in BMSCs-CCD might lend hope for developing BMSC-based therapeutic approaches against CCD-associated skeletal diseases. +circulation_biomarker_prognosis_up 30506730 hsa-mir-335 Breast Neoplasms Authors aim to investigate the role of circulating miRNA-335 as a diagnostic and prognostic marker for breast cancer. +genetics_overexpression_promote 30506722 hsa-mir-98 Colorectal Neoplasms Then, the CRC cells were transfected with miR-98 mimic or miR-98 inhibitor to investigate the potential effect of miR-98 overexpression and depletion on CRC cell proliferation, migration, invasion, and apoptosis. +lncRNA target 30506718 hsa-mir-193a Colonic Neoplasms CONCLUSION: Our results indicated that miR-193a-5p acts as a tumor suppressor miRNA and its downregulation plays an important role in metastasis via upregulation of metastasis-related genes in CRC. +genetics_overexpression_promote 30506716 hsa-mir-452 Carcinoma, Renal Cell Our results showed that miR-452 was overexpressed in ccRCC tissues and cells, and upregulation of miR-452 predicted a poor 5-year survival in ccRCC patients. +lncRNA target 30505497 hsa-mir-497 Carcinoma, Non-Small-Cell Lung CONCLUSIONS: We demonstrated that miR-497 may have the effect of reversing gefitinib resistance and increasing the sensitivity of NSCLC cells to EGFR-TKIs by inhibiting the expression of IGF-1R and reducing activation of the downstream AKT signaling pathway. +other 30504786 hsa-mir-224 Liver Neoplasms We purified microRNA from the HepG2 liver cancer cell line using the purification microdevice and confirmed the expression level of miR-224, which is a potential biomarker for liver cancer. +other 30504757 hsa-mir-146b Fibrosis CONCLUSIONS miR-146b could regulate the expression of circRNAs in HSCs, which might take part in the formation and development of hepatic fibrosis. +lncRNA target 30504754 hsa-mir-26b Colonic Neoplasms In addition, further experiments revealed that miR-26b was a direct target of PVT1 and could inhibit cell migration, invasion, and proliferation in colon cancer. CONCLUSIONS Our results suggest that PVT1 could promote metastasis and proliferation of colon cancer via endogenous sponging and inhibiting the expression of miR-26b, which may highlight the significance of lncRNA PVT1 in colon cancer tumorigenesis. +epigenetics 30504727 hsa-mir-10b Uterine Cervical Neoplasms CONCLUSION miR-10b acts as a tumor suppressor in CC by suppressing oncogenic Tiam1, and its expression may be downregulated through methylation of TFAP2A binding element by HPV. +circRNA target 30504704 hsa-mir-618 Breast Neoplasms Rescue assays also illustrated an oncogenic function of circ_0005230 in BC via acting as a miR-618 sponge to promote CBX8 expression. CONCLUSION circ_0005230/miR-618/CBX8 axis might play a key role in BC tumorigenesis and development. +other 30504380 hsa-mir-182 Adenocarcinoma of Lung RESULTS: The expression levels of miR-182 and miR-210 were significantly higher in the Ad-MPE than in the BPE samples. +other 30504380 hsa-mir-182 Pleural Effusion, Malignant RESULTS: The expression levels of miR-182 and miR-210 were significantly higher in the Ad-MPE than in the BPE samples. +other 30504380 hsa-mir-210 Pleural Effusion, Malignant RESULTS: The expression levels of miR-182 and miR-210 were significantly higher in the Ad-MPE than in the BPE samples. +other 30504380 hsa-mir-210 Adenocarcinoma of Lung RESULTS: The expression levels of miR-182 and miR-210 were significantly higher in the Ad-MPE than in the BPE samples. +transcription factor target 30503969 hsa-mir-621 Carcinoma, Hepatocellular Besides, the miR-621 and/or SETDB1 axis improved the radiosensitivity of HCC cells via activating the p53-signaling pathway. +genetics_overexpression_promote 30503931 hsa-mir-181a Carcinoma, Hepatocellular Functionally, overexpression of miR-181a-5p inhibited, whereas decreased expression of miR-181a-5p promoted HCC cells proliferation in vitro. +genetics_GWAS 30503865 hsa-mir-423 Abortion, Habitual Our study found that one SNP rs6505162C>A in miR-423 coding region was associated with the increase risk of humanunexplained RPL (URPL), but no differences were found in another SNP rs8067576 A>T. +lncRNA target 30503840 hsa-mir-351 Reperfusion Injury, Intestinal Ischemia 5/ MAPK13 should be one effective drug target for the treatment of II/R injury. +circulation_biomarker_diagnosis_up 30503831 hsa-mir-195 Diabetes Mellitus, Type 2 In addition, significant (fold change > 2, P < 0.05) longitudinal changes due to IIT in the circulating levels of miR +other 30503831 hsa-mir-145 Diabetes Mellitus, Type 2 3p/5p, which controls TP53-mediated apoptosis, appears to also occur in our study population of humans with early type 2 diabetes. +other 30503831 hsa-mir-483 Diabetes Mellitus, Type 2 3p/5p, which controls TP53-mediated apoptosis, appears to also occur in our study population of humans with early type 2 diabetes. +circulation_biomarker_diagnosis_up 30503831 hsa-mir-138 Diabetes Mellitus, Type 2 In addition, significant (fold change > 2, P < 0.05) longitudinal changes due to IIT in the circulating levels of miR +circulation_biomarker_diagnosis_up 30503831 hsa-mir-20b Diabetes Mellitus, Type 2 In addition, significant (fold change > 2, P < 0.05) longitudinal changes due to IIT in the circulating levels of miR +transcription factor target 30503822 hsa-mir-181b Cerebral Hemorrhage In vivo, downregulated miR-181b increased the HSPA5 level, along with significant elevations of pro-inflammatory cytokines, brain edema, and neurological injury following ICH. In addition, miR-181b has neuroprotective effects that alleviates neurological injury and represents a promising therapeutic strategy in ICH. +lncRNA target 30503814 hsa-mir-124 Persian Gulf Syndrome Results from this study suggest that in vivo inhibition of miR-124 function in the hippocampus is a promising, novel therapeutic approach to improve cognition and neuroendocrine dysfunction in GWI. +lncRNA target 30503385 hsa-mir-125b Breast Neoplasms Decreasing miR-125b expression would have potential therapeutic significance in preventing dissemination of breast cancer cells. We are discussing the putative mechanism of inhibition of the miR-125b expression by vitamin D receptor (VDR) agonists and we suggest that calcitriol and tacalcitol may be used as a miR-125b inhibitor in breast cancer cells expressing VDR. +other 30502648 hsa-mir-21 Autoimmune Diseases It has been reported that microRNA-21 (miR-21) augments Th17 responses and contributes to the pathogenesis of autoimmune diseases. +lncRNA target 30502362 hsa-mir-22 Breast Neoplasms SIGNIFICANCE: MiR-22 downregulated the expression of NK1R-Tr and ERalpha to delay and weaken phosphorylation of ERK1/2 to inhibit proliferation and metastasis of breast cancer cells. +genetics_knock down_suppress 30502345 hsa-mir-150 Leukemia, Myeloid, Acute Additionally, the inhibition of miR-150 abrogated ZFAS1 loss-mediated anti-leukemia effects. In summary, our data demonstrated that ZFAS1 knockdown hampered AML progression by regulating miR-150/Myb and miR-150/Sp1 pathways, providing some potential biomarkers or targets for the diagnosis and treatment of leukemia. +lncRNA target 30502323 hsa-mir-143 Stomach Neoplasms Strategies to restore MIR143-3p or inhibit BRD2 might be developed for treatment of gastric cancer. +genetics_knock down_suppress 30502321 hsa-mir-141 Stomach Neoplasms Further gain-of-function and loss-of-function analysis revealed that miR-141 not only limited the migration and invasion of the gastric cancer cells, but also inhibited the transition of NFs and BMSC to CAFs. CONCLUSION: Our data showed that miR-141 inhibited migration and invasion of gastric cancer cells and inhibited transition from NFs to CAFs via targeting STAT4/wnt/beta-catenin pathway. +other 30502282 hsa-mir-9 Breast Neoplasms ER-positive breast cancers had lower levels of miR-9 than ER-negative breast cancers (P < 0.001), and within the ER-positive group, miR-9 expression was significantly associated with OS (P = 0.02). +genetics_overexpression_suppress 30502089 hsa-mir-139 Glioma Overexpression of miR +lncRNA target 30502088 hsa-mir-216a Asthma In conclusion, these results suggested that miR-216a-5p functions as a negative regulator of H(2)O(2) induced 16HBE cell injury through targeting HMGB1/NF-kB pathway, provided a potential therapeutic target for asthma. +other 30501705 hsa-mir-256 Multiple Myeloma OBJECTIVE: To investigate relationship of miRNA-132, miRNA-256, miRNA-143 and miRNA-145 level with antophagy and apoptosis of multiple mgeloma cells. +other 30501705 hsa-mir-132 Multiple Myeloma OBJECTIVE: To investigate relationship of miRNA-132, miRNA-256, miRNA-143 and miRNA-145 level with antophagy and apoptosis of multiple mgeloma cells. +other 30501705 hsa-mir-145 Multiple Myeloma OBJECTIVE: To investigate relationship of miRNA-132, miRNA-256, miRNA-143 and miRNA-145 level with antophagy and apoptosis of multiple mgeloma cells. +circulation_biomarker_diagnosis_up 30501705 hsa-mir-143 Multiple Myeloma RESULTS: Compared with normal plasma cells, the expression of miRNA-132 and miRNA-125b in myeloma cells increased significantly (P<0.05), and the expression of miRNA-143 and miRNA-145 decreased significantly (P<0.05), but the expression of LC3-/LC3- and Beclin-1 increased significantly (P<0.05). +circulation_biomarker_diagnosis_up 30501705 hsa-mir-125b Multiple Myeloma RESULTS: Compared with normal plasma cells, the expression of miRNA-132 and miRNA-125b in myeloma cells increased significantly (P<0.05), and the expression of miRNA-143 and miRNA-145 decreased significantly (P<0.05), but the expression of LC3-/LC3- and Beclin-1 increased significantly (P<0.05). +transcription factor target 30501692 hsa-mir-1256 Leukemia METHODS The expression levels of miR125b in doxorubicine drug-sensitive and doxorubicine drug-resistant leukemia cell lines.HL-60, K562 and HL-60/Dox, the K562/Dox were detected by using RT-qPCR; the up-regulation or inhibition of miR-1256 expression in HL-60/Dox were performed by electroporation transfection, then the viability of cells treated with doxorubicine of different concentration was detected by CCK-8 method, the proliferation inhibition curve of cells was drawed, and the IC50 was calculated. +other 30501692 hsa-mir-125b Leukemia OBJECTIVE To investigate whether the down-regulation of miR-125b can reverse the drug-resistence of doxorubicine-resistant leukemia cell lines or not, so as to explore a new method for treatment of drug-resistant leukemia patients. CONCLUSION The miR-125b expression in HL-60/Dox and K562/Dox cells has been up-regulated, down-regulation of miR-125b expression can reverse the drug resistance of leukemia cells to doxorubicine. +circulation_biomarker_prognosis_ns 30501399 hsa-mir-451a Leukemia, Myelogenous, Chronic, BCR-ABL Positive Plasma let-7b-5p and miR-451a expression was lower in CML patients, and plasma miR-451a gradually decreased from chronic phase to accelerated phase and blast crisis. Let-7b-5p and miR-451a can be used as potential biomarkers for the diagnosis and prognosis of CML. +circulation_biomarker_prognosis_ns 30501399 hsa-let-7b Leukemia, Myelogenous, Chronic, BCR-ABL Positive Plasma let-7b-5p and miR-451a expression was lower in CML patients, and plasma miR-451a gradually decreased from chronic phase to accelerated phase and blast crisis. Let-7b-5p and miR-451a can be used as potential biomarkers for the diagnosis and prognosis of CML. +other 30501089 hsa-mir-146b Pulmonary Fibrosis miRNA-seq identified differentially regulated miRNAs, including downregulation of miR-29b-3p, miR5p and miR-146b-5p in disease fibroblasts and transfection of their mimics decreased expression of distinct sets of fibrotic signature genes as assessed using a Nanostring fibrosis panel. +other 30501089 hsa-mir-29b Pulmonary Fibrosis miRNA-seq identified differentially regulated miRNAs, including downregulation of miR-29b-3p, miR5p and miR-146b-5p in disease fibroblasts and transfection of their mimics decreased expression of distinct sets of fibrotic signature genes as assessed using a Nanostring fibrosis panel. +other 30501089 hsa-mir-138 Pulmonary Fibrosis miRNA-seq identified differentially regulated miRNAs, including downregulation of miR-29b-3p, miR5p and miR-146b-5p in disease fibroblasts and transfection of their mimics decreased expression of distinct sets of fibrotic signature genes as assessed using a Nanostring fibrosis panel. +other 30500994 hsa-mir-625 Melanoma 5p/PKM2 plays a role in melanoma cell glucose metabolism. +other 30500989 hsa-mir-124 Carcinoma, Hepatocellular Noncoding RNA miR-124 and long noncoding RNA (lncRNA)-metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) were considered to be involved deeply in the progress of HBx-related HCC. +other 30500775 hsa-mir-200 Endometriosis In this study, the roles of miR200s and MALAT1 in ectopic endometrium were investigated. +genetics_knock down_suppress 30500775 hsa-mir-200c Endometriosis Overexpression of miR200c and knockdown of MALAT1 significantly inhibited E2-mediated EMT, suggesting that both miR200c and MALAT1 are involved in the E2-induced EMT process in endometriosis. Therefore, the role of MALAT1/miR200c in EMT is influenced by the presence of estrogen during endometriosis development. +transcription factor target 30500346 hsa-mir-375 Nerve Degeneration After that, cell viability, reactive oxygen species activity, neural apoptosis, neurite degeneration, and hsa-miR-375 gene expression were assessed, respectively. We found ketamine induced neural death, reactive oxygen species augmentation, neural apoptosis, neurite degeneration and hsa-miR-375 upregulation, in hESC-derived neurons. +lncRNA target 30500346 hsa-mir-375 Neurotoxicity Syndromes Overall, this work provided strong evidence showing hsa-miR-375 is an active regulator in anesthesia-induced neural cell death and neural toxicity, possibly via inverse regulation on BDNF gene. +other 30500346 hsa-mir-735 Nervous System Diseases In this work, we used a human embryonic stem cell (hESC)-derived neuron model to assess the expression and function of human microRNA 735 (hsa-miR-375) in regulating ketamine-induced neural cell death and neural toxicity in vitro. +other 30500346 hsa-mir-735 Neurotoxicity Syndromes In this work, we used a human embryonic stem cell (hESC)-derived neuron model to assess the expression and function of human microRNA 735 (hsa-miR-375) in regulating ketamine-induced neural cell death and neural toxicity in vitro. +lncRNA target 30500346 hsa-mir-375 Nervous System Diseases Overall, this work provided strong evidence showing hsa-miR-375 is an active regulator in anesthesia-induced neural cell death and neural toxicity, possibly via inverse regulation on BDNF gene. +lncRNA target 30500068 hsa-mir-186 Osteoarthritis Our findings reveal a novel mechanism by which miR-186 inhibits chondrocyte apoptosis in OA by interacting with SPP1 and regulating PI3K-AKT pathway. +genetics_knock down_promote 30499870 hsa-mir-155 Melanoma Loss of miR-155 and increased expression of WEE1 may contribute to the metastatic phenotype in patients with melanoma. +lncRNA target 30499593 hsa-mir-144 Inflammation Hemin impairs resolution of inflammation via microRNA +circulation_biomarker_diagnosis_up 30499219 hsa-mir-129-2 Ischemic Stroke The blood levels of SYK gene were significantly higher in IS patients, and miR +circulation_biomarker_diagnosis_ns 30499000 hsa-mir-34a Heart Diseases In conclusion, our study suggests that serum EVs retard H9C2 cell senescence through the miR-34a/PNUTS pathway, providing a potential therapy for cardiac aging. +genetics_GWAS 30498453 hsa-mir-499 Arthritis, Rheumatoid In the Caucasian population, the C allele in the miR-499 T > C polymorphism contributed to RA susceptibility. +genetics_overexpression_suppress 30498363 hsa-mir-130a Stomach Neoplasms RESULTS: In the present study, it was demonstrated that the cannabinoid receptor 1 (CB1R) was overexpressed, and miR-23b-3p and miR-130a-5p were downregulated, in GC cells. +genetics_overexpression_suppress 30498363 hsa-mir-23b Stomach Neoplasms RESULTS: In the present study, it was demonstrated that the cannabinoid receptor 1 (CB1R) was overexpressed, and miR-23b-3p and miR-130a-5p were downregulated, in GC cells. +lncRNA target 30498361 hsa-mir-145 Nasopharyngeal Carcinoma UCA1 promotes the proliferation and invasion of NPC cells by sponging miR-145, functionally altering ADAM17 expression targeted by miR-145. +lncRNA target 30498093 hsa-mir-410 Glioma Taken together, this research suggested that silencing OIP5-AS1 may specifically block the Wnt-7b/beta-catenin pathway via targeted up-regulating miR-410, thereby inhibiting growth, invasion and migration while promoting apoptosis in glioma cells. +lncRNA target 30497876 hsa-mir-1 Gallbladder Neoplasms 5p acted as a suppressive miRNA and played vital roles in the growth, migration and invasion of gallbladder carcinoma cell through targeting Notch2. +lncRNA target 30497506 hsa-mir-150 Neonatal Sepsis Moreover, CEBPB and has-miR-150 might function in neonatal sepsis separately through targeting MAPK14 and BCL11B in the regulatory networks. CONCLUSION: TSPO, ZAP70, CEBPB targeting MAPK14, has-miR-150 targeting BCL11B might affect the pathogenesis of neonatal sepsis. +lncRNA target 30497474 hsa-let-7a Lung Neoplasms Out of the 683 let-7a-5p target genes identified from bioinformatics analysis, four genes related to five signaling pathways were confirmed to be involved in lung cancer development. +other 30497428 hsa-mir-20a Gastrointestinal Neoplasms CONCLUSIONS: Base on the findings, the elevated miR-20a expression level is related to poor prognosis of gastrointestinal cancer patients. +other 30497428 hsa-mir-20a Carcinoma The present meta-analysis assessed the prognostic role of miR-20a in various carcinomas. As for other types of carcinomas, the results are still not stable and more studies are required to further identify miR-20a prognostic values. +transcription factor target 30497184 hsa-mir-195 Brain Ischemia This indicates that miR-195 may represent a novel target that regulates neuroinflammation and brain injury, thus offering a new treatment strategy for cerebral ischemic disorders. +transcription factor target 30497068 hsa-mir-155 Pancreatitis TargetScan software, dual-luciferase gene reporter assays and Western blotting were used to assess the target genes of miR +other 30497054 hsa-mir-370 Glioblastoma 3p could be used as therapeutic tool for anti-glioblastoma therapy, but not as a biomarker. +lncRNA target 30496976 hsa-mir-675 Myocardial Reperfusion Injury This study investigated the potential roles and underlying molecular mechanisms of lncRNA H19 and H19-derived miR-675 in regulating myocardial I/R injury in vitro and in vivo. Taken together, these data indicate that H19 inhibition protects the heart against myocardial I/R injury, which may be partly attributed to regulation of the miR-675/PPARalpha axis. +genetics_knock down_suppress 30496951 hsa-mir-137 Sinus Thrombosis, Intracranial After overexpression or knockdown treatments by manual intervention of miR-137, a series of abnormalities were induced, such as ventricular abnormality, bent spine, yolk cyst, closure of swim sac and venous sinus hemorrhage. +genetics_knock down_suppress 30496951 hsa-mir-137 Camptocormia After overexpression or knockdown treatments by manual intervention of miR-137, a series of abnormalities were induced, such as ventricular abnormality, bent spine, yolk cyst, closure of swim sac and venous sinus hemorrhage. +genetics_knock down_suppress 30496951 hsa-mir-137 Rupture After overexpression or knockdown treatments by manual intervention of miR-137, a series of abnormalities were induced, such as ventricular abnormality, bent spine, yolk cyst, closure of swim sac and venous sinus hemorrhage. +other 30496951 hsa-mir-137 Spinal Curvatures The most sensitive larval toxicological endpoint from intervened miR-137 expression was impairment of the central nervous system (CNS), ventricular abnormalities and notochord curvature. +genetics_knock down_suppress 30496951 hsa-mir-137 Ventricular Dysfunction After overexpression or knockdown treatments by manual intervention of miR-137, a series of abnormalities were induced, such as ventricular abnormality, bent spine, yolk cyst, closure of swim sac and venous sinus hemorrhage. The most sensitive larval toxicological endpoint from intervened miR-137 expression was impairment of the central nervous system (CNS), ventricular abnormalities and notochord curvature. +other 30496951 hsa-mir-137 Central Nervous System Diseases The most sensitive larval toxicological endpoint from intervened miR-137 expression was impairment of the central nervous system (CNS), ventricular abnormalities and notochord curvature. +genetics_knock down_suppress 30496951 hsa-mir-137 Endodermal Sinus Tumor After overexpression or knockdown treatments by manual intervention of miR-137, a series of abnormalities were induced, such as ventricular abnormality, bent spine, yolk cyst, closure of swim sac and venous sinus hemorrhage. +other 30496756 hsa-mir-25 Atrial Fibrillation We found that all patients had elevated RyR2 protein expression; however, a cohort of patients with AF had high miR-93, miR-106b, and miR-25 expression. +other 30496518 hsa-mir-192 Liver Diseases The performance of miR-122 and miR-192 for liver and miR-1, miR-133a, miR-133b, and miR-206 for skeletal muscle was compared with 10 enzymatic or protein biomarkers across 27 compounds causing specific types of tissue injury in rat. +other 30496518 hsa-mir-122 Liver Diseases The performance of miR-122 and miR-192 for liver and miR-1, miR-133a, miR-133b, and miR-206 for skeletal muscle was compared with 10 enzymatic or protein biomarkers across 27 compounds causing specific types of tissue injury in rat. +other 30496518 hsa-mir-1 Liver Diseases The performance of miR-122 and miR-192 for liver and miR-1, miR-133a, miR-133b, and miR-206 for skeletal muscle was compared with 10 enzymatic or protein biomarkers across 27 compounds causing specific types of tissue injury in rat. +other 30496518 hsa-mir-206 Liver Diseases The performance of miR-122 and miR-192 for liver and miR-1, miR-133a, miR-133b, and miR-206 for skeletal muscle was compared with 10 enzymatic or protein biomarkers across 27 compounds causing specific types of tissue injury in rat. +other 30496518 hsa-mir-133a Liver Diseases The performance of miR-122 and miR-192 for liver and miR-1, miR-133a, miR-133b, and miR-206 for skeletal muscle was compared with 10 enzymatic or protein biomarkers across 27 compounds causing specific types of tissue injury in rat. +other 30496518 hsa-mir-133b Liver Diseases The performance of miR-122 and miR-192 for liver and miR-1, miR-133a, miR-133b, and miR-206 for skeletal muscle was compared with 10 enzymatic or protein biomarkers across 27 compounds causing specific types of tissue injury in rat. +genetics_knock down_promote 30489194 hsa-mir-20 Osteosarcoma NNT-AS1-overexpressing U2OS cells and NNT-AS1-knockdown OS-732 cells were subject to miR-320a mimic and inhibitor transfection, respectively, to investigate the miR-320a dependency of the osteosarcoma-promoting role of NNT-AS1. CONCLUSION: NNT-As1 functions as a cancer-promoting lncRNA by downregulating miR-320a, thus increasing the protein expression level of beta-catenin, RUNX2 and IGF-1R as well as activation of Akt in osteosarcoma. +genetics_knock down_promote 30489194 hsa-mir-20a Osteosarcoma NNT-AS1-overexpressing U2OS cells and NNT-AS1-knockdown OS-732 cells were subject to miR-320a mimic and inhibitor transfection, respectively, to investigate the miR-320a dependency of the osteosarcoma-promoting role of NNT-AS1. CONCLUSION: NNT-As1 functions as a cancer-promoting lncRNA by downregulating miR-320a, thus increasing the protein expression level of beta-catenin, RUNX2 and IGF-1R as well as activation of Akt in osteosarcoma. +lncRNA target 30488993 hsa-mir-101 Carcinoma, Hepatocellular To conclude, our results support the concept that downregulation of lncRNA NEAT1_2 radiosensitizes hepatocellular carcinoma cells through regulation of miR +lncRNA target 30488762 hsa-mir-153 Carcinoma, Renal Cell In addition, our data reported that the effects of circPCNXL2 inhibition on RCC cells proliferation and invasion could be abolished by miR-153 inhibitors. +lncRNA target 30488739 hsa-mir-130b Osteolysis OBJECTIVE: To reveal other miR-130b-mediated signaling pathway in the involvement of wear particle-induced inflammation and osteolysis. CONCLUSION: The role of miR-130b/FOXF2/NF-kappaB pathway in PIO was firstly revealed, which provided new targets for the treatment of periprosthetic osteolysis. +epigenetics 30488208 hsa-mir-34b Ovarian Neoplasms 2, and MIR-107) hypermethylated in the majority of tumor samples in comparison with paired samples of histologically unchanged tissue (48-57% vs. +epigenetics 30488208 hsa-mir-34c Ovarian Neoplasms 2, and MIR-107) hypermethylated in the majority of tumor samples in comparison with paired samples of histologically unchanged tissue (48-57% vs. +transcription factor target 30487803 hsa-mir-3134a Budd-Chiari Syndrome The CWMV induced silencing system was also used to suppress miR165/166 and miR3134a through expression of miRNA target mimics. +transcription factor target 30487803 hsa-mir-165 Budd-Chiari Syndrome The CWMV induced silencing system was also used to suppress miR165/166 and miR3134a through expression of miRNA target mimics. +other 30487794 hsa-mir-361 Leishmaniasis, Diffuse Cutaneous 3p as a prognostic biomarker in CL caused by L. +other 30487794 hsa-mir-140 Leishmaniasis, Diffuse Cutaneous 3p were significantly more expressed in CL lesions compared to normal skin samples (p = 0.0001 and p < 0.0001, respectively). +other 30487429 hsa-mir-375 Endometriosis The analysis revealed 149 abnormally expressed miRNAs in endometriotic lesions, including extensive upregulation of miR5p and downregulation of miR-375 compared to eutopic cells. +other 30487429 hsa-mir-139 Endometriosis The analysis revealed 149 abnormally expressed miRNAs in endometriotic lesions, including extensive upregulation of miR5p and downregulation of miR-375 compared to eutopic cells. +lncRNA target 30487160 hsa-mir-195 Carcinoma, Non-Small-Cell Lung Thus, CYTOR played an oncogenic role in NSCLC progression through sponging miR-195. +genetics_overexpression_promote 30486894 hsa-mir-296 Carcinoma, Hepatocellular Overexpression of miR +lncRNA target 30486878 hsa-mir-663a Carcinoma, Hepatocellular In addition, the upregulation of miR-663a inhibited the proliferation and invasion of HCC cells in vitro. +genetics_overexpression_suppress 30486864 hsa-mir-6868 Colorectal Neoplasms Overexpression of miR +other 30486562 hsa-mir-34a Leukemia, Lymphocytic, Chronic, B-Cell By comparing with known prognostic factors, receiver operating characteristic (ROC) curves showed that miR-34a was a good predictive factor for the prognosis of CLL (demarcation value was 3.567 6). +other 30485846 hsa-mir-371a Intrahepatic Cholestasis of Pregnancy RESULTS: The expression levels of three miRNAs (miR-371a- 5p, miR5p, and miR-1182) were significantly increased in ICP patients compared to controls; the areas under the receiver operating characteristic (ROC) curves (AUCs) were 0.771, 0.811, and 0.798, respectively. +other 30485846 hsa-mir-1182 Intrahepatic Cholestasis of Pregnancy RESULTS: The expression levels of three miRNAs (miR-371a- 5p, miR5p, and miR-1182) were significantly increased in ICP patients compared to controls; the areas under the receiver operating characteristic (ROC) curves (AUCs) were 0.771, 0.811, and 0.798, respectively. +other 30485846 hsa-mir-6865 Intrahepatic Cholestasis of Pregnancy RESULTS: The expression levels of three miRNAs (miR-371a- 5p, miR5p, and miR-1182) were significantly increased in ICP patients compared to controls; the areas under the receiver operating characteristic (ROC) curves (AUCs) were 0.771, 0.811, and 0.798, respectively. +lncRNA target 30485839 hsa-mir-155 Epilepsy, Temporal Lobe CONCLUSION Our experiments showed that circRNA-0067835 regulated refractory epilepsy progression by acting as a sponge of miR-155 to promote FOXO3a expression, indicating that circRNA-0067835 may serve as a potential therapeutic target for patients with TLE. +other 30485837 hsa-mir-451 Diabetic Nephropathies CONCLUSION: Taken together, these results provide new insight into the association between 150Rik and the miR-451/IGF1R/p38MAPK signaling pathway during DN progression. +epigenetics 30485833 hsa-mir-196a Carcinoma, Endometrioid LOC134466 methylation promotes oncogenesis of endometrial carcinoma through LOC134466/hsa-miR-196a-5p/TAC1 axis. +other 30485610 hsa-mir-199 Oral Submucous Fibrosis 5p may supply important clues for developing therapeutic strategy for OSF. +lncRNA target 30485589 hsa-mir-193a Stomach Neoplasms miR-193a-3p could be a promising target for cancer therapy in cisplatin-resistant gastric cancer. +transcription factor target 30485570 hsa-mir-326 Lung Neoplasms CONCLUSIONS: Our data demonstrate that miR-326/Sp1/KLF3 regulatory axis is involved in the development of lung cancer, which hints the potential target for the further therapeutic strategy against lung cancer. +lncRNA target 30485546 hsa-mir-152 Neuralgia We also found that the microRNA mir-152 in the spinal cord which targets MafB expression decreased after PNI, and intrathecal administration of mir-152 mimic suppressed the development of neuropathic pain. +other 30485532 hsa-mir-125b Stomach Neoplasms Finally, we demonstrated that KDM4B promoted gastric cancer cell invasion in vitro and cancer metastasis in vivo, at least in part, by upregulating miR-125b expression. +genetics_overexpression_suppress 30485529 hsa-mir-9 Neuralgia However, little is known about the role of miR-98 in neuropathic pain development and neuroinflammation. Then, miR-98 was overexpressed in CCI rats and it was found that miR-98 was able to repress neuropathic pain development via inhibiting the neuroinflammation. +genetics_overexpression_suppress 30485529 hsa-mir-98 Neuralgia Taken these together, we reported that overexpression of miR-98 attenuated neuropathic pain development via targeting STAT3 in CCI rat models. +lncRNA target 30485528 hsa-mir-377 Lung Neoplasms 5p inhibited cell development and regulated cell cycle distribution and EMT by targeting AKT1, which provided a theoretical basis for further study of lung carcinoma therapeutics. +genetics_knock down_suppress 30485524 hsa-mir-137 Melanoma Knockdown of miR-137 significantly reduced the migrated and invasive abilities of melanoma A375 and WM451 cells. +lncRNA target 30485520 hsa-mir-9 Diabetic Retinopathy Our study demonstrated that miR-9 could inhibit retinal neovascularization of DR and tubule formation, and promote apoptosis in RMECs by targeting VEGFA. +other 30485514 hsa-mir-194 Reperfusion Injury miR-194 was downregulated following renal ischemia-reperfusion injury; however, the function and mechanism of miR-194 in renal ischemia-reperfusion injury have not yet been fully understood. +genetics_knock down_promote 30485513 hsa-mir-145 Squamous Cell Carcinoma of Head and Neck The knockdown of miR-145 promoted the proliferation, invasion, and EMT progression of LSCC cells. +other 30485507 hsa-mir-9 Coronary Artery Disease 3p was downregulated by oxLDL treatment in endothelial cell. +other 30485503 hsa-mir-145 Glioblastoma These data suggested that patients with glioblastoma with lower miR-145 expression are prone to shorter overall survival. +lncRNA target 30485502 hsa-mir-145 Colorectal Neoplasms CONCLUSION: miR-145 can inhibit the viability, migration, and invasion through addressing MAPK signaling pathway by targeting TUSC3 in CRC cells, providing a novel biomarker for treatment of CRC. +lncRNA target 30485500 hsa-mir-495 pancreatic adenocarcinoma Further research on the function of the hsa-miR-495 and its target genes in the KEGG pathway may provide references for treatment of PAAD. +other 30485486 hsa-mir-133 Breast Neoplasms Our data showed that miR-25 and miR-133 were downregulated, and miR-17 was upregulated in patients with breast cancer. The reduced expression of miR-133 and miR-25 is significantly associated with clinical stage, metastasis, and survival time of patients with breast cancer. +other 30485486 hsa-mir-25 Breast Neoplasms Our data showed that miR-25 and miR-133 were downregulated, and miR-17 was upregulated in patients with breast cancer. The reduced expression of miR-133 and miR-25 is significantly associated with clinical stage, metastasis, and survival time of patients with breast cancer. +lncRNA target 30485482 hsa-mir-186 Osteosarcoma Furthermore, our data revealed that HIF-1alpha was a downstream target of miR +circulation_biomarker_diagnosis_up 30485259 hsa-mir-221 Pulmonary Embolism Correlation analysis showed that plasma miR-221 levels in patients with acute PE were positively correlated with levels of BNP (r=0.842, P<0.05), troponin I (r=0.853; P<0.05), and D-dimer (r=0.838; P<0.05). +transcription factor target 30484954 hsa-mir-125b Neointimal Hyperplasia In summary, our findings revealed that MSC-Exo can transfer miR-125b to VSMCs and inhibit VSMC proliferation and migration in vitro and neointimal hyperplasia in vivo by repressing Myo1e, indicating that miR-125b may be a therapeutic target in the treatment of vascular diseases. +lncRNA target 30484892 hsa-mir-338 Osteosarcoma 3p suppression significantly increased cell viability and colony numbers, promoted cell migration, and invasion, but suppressed cell apoptosis in MG-63 and U2OS cells. +genetics_overexpression_promote 30484891 hsa-mir-203 Inflammation On the contrary, overexpression of miR-203 showed the opposite trend in cell apoptosis and inflammation. Herein, we suggest that miR-203 promoted cell apoptosis and inflammation induced by LPS via targeting NFIL3. +other 30484891 hsa-mir-203 Myocarditis In this work, we aimed to explore the roles and potential mechanisms of miR-203 in myocarditis in vitro. +genetics_GWAS 30484703 hsa-mir-146a Thyroid Cancer, Papillary Pooled results showed no association between the miR-146a rs2910164 polymorphism and PTC (OR = 1.001, 95% confidence interval [CI] 0.893-1.121). Conclusions: The results of our meta-analysis indicated that the miR-146a rs2910164 variant genotype has no effect on susceptibility to PTC. +genetics_overexpression_promote 30484492 hsa-mir-497 Stomach Neoplasms These findings suggested that overexpression of miR-497 inhibited proliferation and induced apoptosis in gastric cancer through the suppression of FGFR1. +lncRNA target 30484106 hsa-mir-338 Osteoarthritis The present study, for the first time, illustrates the role of hsa-miR338-3p in synovial fibrosis in OA patients and the related mechanism, which is of importance to the treatment of OA and its complications by targeting the FLSs and synovial tissue. +genetics_knock down_promote 30483807 hsa-mir-154 Urinary Bladder Neoplasms Overexpression of miR154 led to significant decrease in the proliferation, migration, and invasion of BCa cells, while knockdown of miR154 yielded the opposite effect. +genetics_overexpression_promote 30483794 hsa-mir-1271 Leukemia, Myeloid, Acute Overexpression of miR12715p significantly reduced the mRNA and protein expression levels of ZIC2 in AML193 and OCIAML2 cells by reverse transcriptionquantitative polymerase chain reaction analysis and western blotting. +other 30483784 hsa-mir-133a Breast Neoplasms Therefore, miR133a3p may represent a novel molecular marker for diagnosis and treatment of breast cancer, and puerarin may represent a promising clinical drug for treatment of patients with breast cancer. +transcription factor target 30483755 hsa-mir-381 Stomach Neoplasms In this study, we report that the expression of miR381 and miR489 is downregulated and is negatively correlated with that of CUL4B in GC tissues and cell lines. Taken together, the findings of this study suggest that the miR381/miR489mediated expression of CUL4B modulates the proliferation and invasion of GC cells via the Wnt/betacatenin pathway, which indicates that the miR381/miR489CUL4B axis is critical in the control of GC tumourigenesis. +transcription factor target 30483755 hsa-mir-489 Stomach Neoplasms In this study, we report that the expression of miR381 and miR489 is downregulated and is negatively correlated with that of CUL4B in GC tissues and cell lines. Taken together, the findings of this study suggest that the miR381/miR489mediated expression of CUL4B modulates the proliferation and invasion of GC cells via the Wnt/betacatenin pathway, which indicates that the miR381/miR489CUL4B axis is critical in the control of GC tumourigenesis. +genetics_overexpression_promote 30483744 hsa-mir-3666 Glioblastoma Overexpression of miR3666 significantly decreased the expression of KDM2A in GBM cells. +lncRNA target 30483740 hsa-mir-208b Atrial Fibrillation The circRNAassociated ceRNA networks revealed that dysregulated circRNAs in NPAF may be involved in regulating hsamicroRNA (miR)208b and hsamiR21. +lncRNA target 30483740 hsa-mir-21 Atrial Fibrillation The circRNAassociated ceRNA networks revealed that dysregulated circRNAs in NPAF may be involved in regulating hsamicroRNA (miR)208b and hsamiR21. +other 30483731 hsa-mir-1197 Carcinoma, Pancreatic Ductal A prognostic signature consisting of four hub miRNAs (miR1197, miR2182, miR889 and miR487a) associated with pathological T stage was identified to stratify the patients with earlystage PDAC into high and low risk groups. +other 30483731 hsa-mir-487a Carcinoma, Pancreatic Ductal A prognostic signature consisting of four hub miRNAs (miR1197, miR2182, miR889 and miR487a) associated with pathological T stage was identified to stratify the patients with earlystage PDAC into high and low risk groups. +other 30483731 hsa-mir-889 Carcinoma, Pancreatic Ductal A prognostic signature consisting of four hub miRNAs (miR1197, miR2182, miR889 and miR487a) associated with pathological T stage was identified to stratify the patients with earlystage PDAC into high and low risk groups. +other 30483731 hsa-mir-2182 Carcinoma, Pancreatic Ductal A prognostic signature consisting of four hub miRNAs (miR1197, miR2182, miR889 and miR487a) associated with pathological T stage was identified to stratify the patients with earlystage PDAC into high and low risk groups. +other 30483126 hsa-mir-466f Medulloblastoma These results allowed us to describe a new EMT molecular network, involving the down-regulation of miR-466f-3p together with the concordant up-regulation of Vegfa and Nrp2, that sustains the mesenchymal phenotype of SHH MB CSCs. +genetics_knock down_promote 30483048 hsa-mir-210 Dementia, Vascular 5p agomir to VD rats aggravated phenotypes of cognitive impairment and synaptic loss. +other 30482933 hsa-mir-502 Insulin Resistance 85. +genetics_overexpression_promote 30482933 hsa-mir-502 Ataxia Telangiectasia Overexpression of miR +circulation_biomarker_diagnosis_up 30482883 hsa-mir-155 Depressive Disorder, Major With quantitative real-time PCR (qRT-PCR) analysis, we confirmed that cellular and serum levels of miR-155 were up-regulated in individuals with depression compared with those in healthy controls. These results suggest that miR-155 is an important factor in the pathophysiology of depression. +circulation_biomarker_diagnosis_ns 30482723 hsa-mir-150 Schistosomiasis The level of serum miR5p showed the most promising potential for grading hepatic fibrosis in schistosomiasis. +circulation_biomarker_diagnosis_ns 30482723 hsa-mir-150 Liver Cirrhosis The level of serum miR5p showed the most promising potential for grading hepatic fibrosis in schistosomiasis. +other 30482236 hsa-mir-185 Breast Neoplasms CONCLUSION: In conclusion, our data concludes that LINC00511/miR3p/E2F1/Nanog axis facilitates the breast cancer stemness and tumorigenesis, providing a vital insight for them. +lncRNA target 30481782 hsa-mir-24 Ovarian Neoplasms In a word, 20(S)-Rg3 inhibited the Warburg effect in ovarian cancer cells via H19/miR +lncRNA target 30481780 hsa-mir-650 Carcinoma, Hepatocellular Mechanistically, Reporter luciferase assay was performed to reveal whether large tumor suppressor kinase 2 (LATS2) was a direct target of miR-650 in HCC cells. +lncRNA target 30481761 hsa-mir-155 Fibrosis CONCLUSION Our experiments showed that circRNA-0067835 regulated liver fibrosis progression by acting as a sponge of miR-155 to promote FOXO3a expression, indicating that circRNA-0067835 may serve as a potential therapeutic target for patients with liver fibrosis. +lncRNA target 30481748 hsa-mir-129 Osteosarcoma 5p, and thus activates the PI3K-Akt signaling pathway and provides potential therapeutic targets for osteosarcoma treatment. +other 30481637 hsa-mir-155 Myocardial Infarction, Acute We aimed to investigate changes in the levels of cytokines (IL-6, TNF-alpha and IL-10), miRNAs profiles (miR-146 and miR-155) and distribution of different monocyte subsets (CD14++CD16-, CD14++CD16+, CD14+CD16++) in the acute and post-healing phases of AMI. +other 30481625 hsa-mir-128b Cerebral Infarction CONCLUSIONS: miR-128b promoted cerebral infarction in MCAO rats by regulating Bcl-2 and Caspase 3 expression. +genetics_knock down_promote 30481109 hsa-mir-451 Carcinoma, Non-Small-Cell Lung Moreover, TATDN1 knockdown improved DDP-sensitivity in NSCLC patients by regulation of miR-451/TRIM66 axis. +genetics_overexpression_suppress 30481052 hsa-mir-3666 Lung Neoplasms Finally, we identified that the PI3K-AKT and epilthelial-mesenchymal transition (EMT) signaling pathways were inhibited by miR-3666 overexpression in lung cancer cells. In conclusion, our data indicate that miR-3666 could play an essential role in cell proliferation, migration, and invasiveness by targeting BPTF and partly inhibiting the PI3K-AKT and EMT signaling pathways in human lung cancers. +genetics_overexpression_promote 30480817 hsa-mir-142 Breast Neoplasms 3p was downregulated, while Bach-1 mRNA and protein both were overexpressed in the breast cancer tumors. +other 30480816 hsa-mir-107 Glioma Meanwhile, miR-107 was significantly downregulated in glioma cell lines. In summary, our findings indicated that NEAT1/miR-107/CDK14 axis participated in glioma development. +genetics_overexpression_promote 30480807 hsa-mir-124 Enterocolitis, Necrotizing RESULTS: miR-124 was overexpressed in the NEC tissues, while ROCK1 and MYPT1 was downregulated in the NEC tissues. +lncRNA target 30480744 hsa-mir-124 Diabetic Retinopathy CONCLUSIONS: MALAT1 might play important roles in DR by regulating Sag and Guca1a through miR3p and regulating Pde6g through miR-125b-5p. +transcription factor target 30480622 hsa-mir-135b Melanoma Next, we studied the impact of miR-135b or its inhibitor on cell proliferation, migration, or apoptosis in either primary melanocytes or the melanoma cell line, respectively. +genetics_overexpression_promote 30479571 hsa-mir-133b Esophageal Squamous Cell Carcinoma Finally, miR-133b overexpression suppressed tumor growth and lung metastases of ESCC in vivo. +lncRNA target 30479565 hsa-mir-199a Esophageal Squamous Cell Carcinoma RESULTS: We found that the AK4 gene is one of the targets of miR-199a-3p, which promotes the radioresistance of EC cells. +transcription factor target 30479563 hsa-mir-451a Esophageal Squamous Cell Carcinoma We previously found low expression of miR-144/451 was closely related with the risk for esophageal cancer. miR-144/451 cluster played proto oncogene role in esophageal cancer by inhibiting cell invasion. +transcription factor target 30479563 hsa-mir-144 Esophageal Squamous Cell Carcinoma We previously found low expression of miR-144/451 was closely related with the risk for esophageal cancer. miR-144/451 cluster played proto oncogene role in esophageal cancer by inhibiting cell invasion. +genetics_GWAS 30479191 hsa-mir-4268 Precursor Cell Lymphoblastic Leukemia-Lymphoma RESULTS: We identified three SNPs in miR-4268, miR-4751 and miR-3117 associated with mucositis, diarrhea and vomiting, respectively. +genetics_GWAS 30479191 hsa-mir-3117 Precursor Cell Lymphoblastic Leukemia-Lymphoma RESULTS: We identified three SNPs in miR-4268, miR-4751 and miR-3117 associated with mucositis, diarrhea and vomiting, respectively. +genetics_GWAS 30479191 hsa-mir-4268 Mucositis RESULTS: We identified three SNPs in miR-4268, miR-4751 and miR-3117 associated with mucositis, diarrhea and vomiting, respectively. +genetics_GWAS 30479191 hsa-mir-4751 Mucositis RESULTS: We identified three SNPs in miR-4268, miR-4751 and miR-3117 associated with mucositis, diarrhea and vomiting, respectively. +genetics_GWAS 30479191 hsa-mir-4751 Precursor Cell Lymphoblastic Leukemia-Lymphoma RESULTS: We identified three SNPs in miR-4268, miR-4751 and miR-3117 associated with mucositis, diarrhea and vomiting, respectively. +genetics_GWAS 30479191 hsa-mir-3117 Mucositis RESULTS: We identified three SNPs in miR-4268, miR-4751 and miR-3117 associated with mucositis, diarrhea and vomiting, respectively. +lncRNA target 30479019 hsa-mir-145 Fibrosis Taken together, our results describe a novel miRZEB2-p53 regulatory line might participate in the senescence of activated HSCs and might carry potential therapeutic targets for restraining liver fibrosis. +lncRNA target 30479013 hsa-mir-204 Retinoblastoma In conclusion, NEAT1 promotes the development of RB via miR-204/CXCR4 axis, which provides a new target for the treatment of RB disease. +other 30478938 hsa-mir-138 Carcinoma, Renal Cell In short, our current study reveals the role of the circ-ZNF609/miR5p/FOXP4 regulatory network in renal carcinoma and provides a new perspective for the pathogenesis of renal carcinoma. +genetics_knock down_promote 30478856 hsa-mir-613 Thyroid Cancer, Papillary Mechanism assays noted that knockdown of LINC00460 suppressed cell proliferation, migration, and invasion, and inhibited expression of sphingosine kinase 2 (SphK2, a target of miR-613) in PTC cells, at least in part, by regulating miR-613. These findings suggested that LINC00460 could function as a competing endogenous RNA to regulate SphK2 expression by sponging miR-613 in PTC. +transcription factor target 30478832 hsa-mir-592 Hypoplastic Left Heart Syndrome This study demonstrates that downregulation of miR-592 prevents CHD and hypoplastic heart by inhibition of the Notch signaling pathway via negatively binding to KCTD10. +transcription factor target 30478832 hsa-mir-592 Pulmonary Arterial Hypertension This study demonstrates that downregulation of miR-592 prevents CHD and hypoplastic heart by inhibition of the Notch signaling pathway via negatively binding to KCTD10. +genetics_GWAS 30478668 hsa-mir-152 Pre-Eclampsia CONCLUSIONS: A lack of relationship between the polymorphism of miRNA-152 rs12940701 gene and preeclampsia development has been shown. +other 30478292 hsa-mir-146a Colitis Here we study the relationship between bacterial antigens and inflammatory stimuli, and miR-146a expression using IEC lines and models of colitis (trinitrobenzenesulfonic acid (TNBS), dextran sulfate sodium (DSS) and the CD4 CD62L T cell transfer model). +other 30478292 hsa-mir-146a Crohn Disease Regulation of miR-146a abundance and its role in intestinal inflammation and particularly in intestinal epithelial cells (IECs) has been poorly studied. Intestinal inflammation induced by chemical damage to the epithelium (DSS and TNBS models) induces miR-146a, but no effect is observed in the lymphocyte transfer model. +other 30478046 hsa-mir-15b Leukemia, Myeloid, Acute Deletion of murine miR-15a/16-1 and miR-15b/16-2 has been demonstrated to promote B cell malignancies. +other 30478046 hsa-mir-16-1 Leukemia, Myeloid, Acute Deletion of murine miR-15a/16-1 and miR-15b/16-2 has been demonstrated to promote B cell malignancies. +other 30478046 hsa-mir-15a Leukemia, Myeloid, Acute Deletion of murine miR-15a/16-1 and miR-15b/16-2 has been demonstrated to promote B cell malignancies. +lncRNA target 30477744 hsa-mir-23b Inflammatory Bowel Diseases Our data indicate that suppression of ANRIL may inhibit the development of UC by regulating miR-323b-5p/TLR4/MyD88/NF-kappaB pathway. ANRIL/miR-323b-5p/TLR4/MyD88/NF-kappaB pathway may provide a new strategy for UC therapy. +virus_miRNA 30477559 ebv-mir-BART8 Nasopharyngeal Carcinoma EBV-miR-BART8-3p induces epithelial-mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma cells through activating NF-κB and Erk1/2 pathways. +exosome 30477383 hsa-mir-4306 Coronary Artery Disease RESULTS: EV-contained miR-4306 released from HMDMs was significantly upregulated in coronary artery disease. +transcription factor target 30476915 hsa-mir-135a Colorectal Neoplasms CONCLUSION Our results indicated that miR-135a alleviated DSS-induced inflammation and activated STAT3 signal in colonic cells. +other 30476907 hsa-mir-16-2 Uterine Cervical Neoplasms miR2* is a newly discovered miRNA that participates in diagnosis and prognosis of hepatocellular carcinoma, cervical cancer and chronic lymphocytic leukemia. +other 30476907 hsa-mir-16-2 Carcinoma, Hepatocellular miR2* is a newly discovered miRNA that participates in diagnosis and prognosis of hepatocellular carcinoma, cervical cancer and chronic lymphocytic leukemia. +other 30476907 hsa-mir-16-2 Leukemia, Lymphocytic, Chronic, B-Cell miR2* is a newly discovered miRNA that participates in diagnosis and prognosis of hepatocellular carcinoma, cervical cancer and chronic lymphocytic leukemia. +other 30476907 hsa-mir-16-2 Osteoporosis 2* in patient bone tissue with osteoporosis was negatively correlated with bone formation related genes. +other 30476706 hsa-mir-182 Breast Neoplasms Next, we also identified potential prognostic FFLs for subtypes of breast cancer, such as the hsa-miR5p_JUN_XIST in basal-like subtype. +other 30475986 hsa-mir-520e Carcinoma, Non-Small-Cell Lung Our findings reveal a novel negative-feedback mechanism in TGF-beta signaling and the expression level of miR-520e could be a predictive biomarker for NSCLC metastasis. +circulation_biomarker_diagnosis_up 30475754 hsa-mir-940 Nasopharyngeal Carcinoma RESULTS: Both the screening and the validation phases showed that three miRNAs (miR-548q, miR-630 and miR-940) in the plasma of NPC patients were up-regulated compared to those of controls. +circulation_biomarker_diagnosis_up 30475754 hsa-mir-548q Nasopharyngeal Carcinoma RESULTS: Both the screening and the validation phases showed that three miRNAs (miR-548q, miR-630 and miR-940) in the plasma of NPC patients were up-regulated compared to those of controls. +other 30475081 hsa-mir-129 Carcinoma, Non-Small-Cell Lung PURPOSE: To investigate the effect of microRNA-129 on the migration and invasion in (Non small cell lung cancer) NSCLC cells and involved mechanism. +lncRNA target 30474931 hsa-mir-485 Thyroid Cancer, Papillary In validation, RP11-159F24.1 (up-regulated; P = 0.0013) showed an opposite expression pattern with its target miR-485 (down-regulated; P = 0.0013) in PTC, indicating that the RP11-159F24.1/miR-485/mRNAs axis might play an important role in the development of PTC. +other 30474870 hsa-mir-34a Coronary Artery Disease We demonstrated that the expression level of miR-34a was lower in CAD tissues than in normal arterial tissues and the expression of miR-34a was negatively correlated with C2dat1 expression. +transcription factor target 30474799 hsa-mir-1288 Schizophrenia Mediated Inhibition and Contributes to the Risk of Schizophrenia in the Chinese Han Population. +genetics_knock down_promote 30474570 hsa-mir-219 Ovarian Neoplasms 5p led to suppression of proliferation, invasion and migration of the ovarian cancer cell line, SKOV3, by targeting HMGA2. +transcription factor target 30474556 hsa-mir-382 Colorectal Neoplasms Thus, MIR-382 may be able to be developed as a novel treatment target for CRC. +genetics_knock down_promote 30474270 hsa-mir-194 Pancreatic Carcinoma Moreover, the effect of H19 knockdown on PFTK1 protein and the cell proliferation and migration could be partially reversed by miR-194 inhibition; H19/miR-194 axis modulated PDAC cell proliferation and migration through PFTK1 downstream Wnt signaling. Results suggested that rescuing miR-194 expression in PDAC can inhibit lncRNA H19 and PFTK1 expression, subsequently suppressing PDAC cell proliferation and migration. +transcription factor target 30473536 hsa-mir-221 Carcinoma, Hepatocellular Our observations are consistent with a model in which alpha-pinene inhibits miR221 expression, which leads to G(2)/M-phase arrest and activation of CDKN1B/p27-CDK1 and ATM-p53-Chk2 pathways that suppress human hepatoma tumor progression. +lncRNA target 30473219 hsa-mir-4778 Uterine Cervical Neoplasms 3p reduces the vitality, proliferation, and migration of radioresistant cervical cancer cells and may regulate the radiosensitivity of cervical cancer by targeting and regulating NR2C2 and Med19 expression. +transcription factor target 30472896 hsa-mir-133a Diabetes Mellitus Ectopic expression of miR-133a in endothelial cells is involved in endothelial dysfunction in diabetes. Finally, berberine reduced miR-133a expression, and increased both BH4 levels and NO production in cultured endothelial cells treated with high glucose.Conclusion: Berberine improves vascular dementia in diabetes, which is possibly related to the suppression of miR-133a ectopic expression in endothelial cells. +transcription factor target 30472896 hsa-mir-133a Dementia, Vascular Ectopic expression of miR-133a in endothelial cells is involved in endothelial dysfunction in diabetes. Finally, berberine reduced miR-133a expression, and increased both BH4 levels and NO production in cultured endothelial cells treated with high glucose.Conclusion: Berberine improves vascular dementia in diabetes, which is possibly related to the suppression of miR-133a ectopic expression in endothelial cells. +other 30472788 hsa-mir-423 Shock, Cardiogenic 5p at baseline is associated with markers of hypoperfusion and seems to independently predict 90 day all-cause mortality. +lncRNA target 30472379 hsa-mir-103 Colorectal Neoplasms Functionally, our data show that such TP73AS1-induced PTEN expression through binding to miR103 facilitated CRC cell proliferation. +transcription factor target 30472218 hsa-mir-206 Cognitive Dysfunction More than 40 miRNAs resulted as dysregulated, and miR-206 was the only miRNA that was found as differentially expressed in patients with MCI by more than two studies. +lncRNA target 30472203 hsa-mir-101 Retinoblastoma In conclusion, these findings suggest that XIST may facilitate the progression of RB through acting as a ceRNA for miR-101 to mediate the expression of ZEB1 and ZEB2. +other 30472057 hsa-mir-532 Intervertebral Disc Degeneration RESULTS: MiR-532 was significantly upregulated in patient with intervertebral disc degeneration. +circulation_biomarker_diagnosis_ns 30472037 hsa-mir-126 Obesity CONCLUSIONS: Combination of exercise and diet control can effectively improve glycolipid metabolism of obese adolescents, and thus their microvascular endothelial function, which might be related to changes in serum miRNA-126. +other 30471511 hsa-mir-155 Implantation Failure miR-155 and miR-146a demonstrated significant down-regulation in RIF patients. +other 30471511 hsa-mir-146a Implantation Failure miR-155 and miR-146a demonstrated significant down-regulation in RIF patients. +other 30471109 hsa-mir-143 Urinary Bladder Neoplasms In the present study, we found that miR143HG expression was significantly downregulated in bladder cancer tissues (BCa) compared with normal tissues. +genetics_knock down_suppress 30471109 hsa-mir-1275 Urinary Bladder Neoplasms Restoration of miR-1275 or knockdown of AXIN2 significantly rescued the proliferation, migration, and invasion abilities of BCa cells. In summary, our findings demonstrated that miR143HG/miR-1275/AXIN2 axis regulates BCa development by modulating the Wnt/beta-catenin pathway. +lncRNA target 30471108 hsa-mir-27b Carcinoma, Non-Small-Cell Lung These data revealed a role for KCNQ1OT1 as an oncogene through miR-27b-3p/HSP90AA1 axis during NSCLC progression. +other 30470910 hsa-mir-28 Atrial Fibrillation RESULTS: Compared with the control rats, CIH rats showed higher atrial interstitial collagen deposition, increased AF inducibility, and increased miR-1, miR-21, miR-133a, miR-328, TGF-beta1, and CTGF levels. Treatment with doxycycline significantly attenuated CIH-induced atrial fibrosis, improved AF inducibility, and reduced miR-1, miR-21, miR-133a, miR-328, TGF-beta1, and CTGF. +other 30470910 hsa-mir-28 Fibrosis Treatment with doxycycline significantly attenuated CIH-induced atrial fibrosis, improved AF inducibility, and reduced miR-1, miR-21, miR-133a, miR-328, TGF-beta1, and CTGF. +other 30470910 hsa-mir-133a Atrial Fibrillation RESULTS: Compared with the control rats, CIH rats showed higher atrial interstitial collagen deposition, increased AF inducibility, and increased miR-1, miR-21, miR-133a, miR-328, TGF-beta1, and CTGF levels. Treatment with doxycycline significantly attenuated CIH-induced atrial fibrosis, improved AF inducibility, and reduced miR-1, miR-21, miR-133a, miR-328, TGF-beta1, and CTGF. +other 30470910 hsa-mir-133a Fibrosis Treatment with doxycycline significantly attenuated CIH-induced atrial fibrosis, improved AF inducibility, and reduced miR-1, miR-21, miR-133a, miR-328, TGF-beta1, and CTGF. +other 30470910 hsa-mir-28 Ichthyosis, Lamellar RESULTS: Compared with the control rats, CIH rats showed higher atrial interstitial collagen deposition, increased AF inducibility, and increased miR-1, miR-21, miR-133a, miR-328, TGF-beta1, and CTGF levels. Treatment with doxycycline significantly attenuated CIH-induced atrial fibrosis, improved AF inducibility, and reduced miR-1, miR-21, miR-133a, miR-328, TGF-beta1, and CTGF. +other 30470910 hsa-mir-1 Ichthyosis, Lamellar RESULTS: Compared with the control rats, CIH rats showed higher atrial interstitial collagen deposition, increased AF inducibility, and increased miR-1, miR-21, miR-133a, miR-328, TGF-beta1, and CTGF levels. Treatment with doxycycline significantly attenuated CIH-induced atrial fibrosis, improved AF inducibility, and reduced miR-1, miR-21, miR-133a, miR-328, TGF-beta1, and CTGF. +other 30470910 hsa-mir-21 Ichthyosis, Lamellar RESULTS: Compared with the control rats, CIH rats showed higher atrial interstitial collagen deposition, increased AF inducibility, and increased miR-1, miR-21, miR-133a, miR-328, TGF-beta1, and CTGF levels. Treatment with doxycycline significantly attenuated CIH-induced atrial fibrosis, improved AF inducibility, and reduced miR-1, miR-21, miR-133a, miR-328, TGF-beta1, and CTGF. +other 30470910 hsa-mir-21 Atrial Fibrillation RESULTS: Compared with the control rats, CIH rats showed higher atrial interstitial collagen deposition, increased AF inducibility, and increased miR-1, miR-21, miR-133a, miR-328, TGF-beta1, and CTGF levels. Treatment with doxycycline significantly attenuated CIH-induced atrial fibrosis, improved AF inducibility, and reduced miR-1, miR-21, miR-133a, miR-328, TGF-beta1, and CTGF. +other 30470910 hsa-mir-1 Fibrosis Treatment with doxycycline significantly attenuated CIH-induced atrial fibrosis, improved AF inducibility, and reduced miR-1, miR-21, miR-133a, miR-328, TGF-beta1, and CTGF. +other 30470910 hsa-mir-1 Atrial Fibrillation RESULTS: Compared with the control rats, CIH rats showed higher atrial interstitial collagen deposition, increased AF inducibility, and increased miR-1, miR-21, miR-133a, miR-328, TGF-beta1, and CTGF levels. Treatment with doxycycline significantly attenuated CIH-induced atrial fibrosis, improved AF inducibility, and reduced miR-1, miR-21, miR-133a, miR-328, TGF-beta1, and CTGF. +other 30470910 hsa-mir-133a Ichthyosis, Lamellar RESULTS: Compared with the control rats, CIH rats showed higher atrial interstitial collagen deposition, increased AF inducibility, and increased miR-1, miR-21, miR-133a, miR-328, TGF-beta1, and CTGF levels. Treatment with doxycycline significantly attenuated CIH-induced atrial fibrosis, improved AF inducibility, and reduced miR-1, miR-21, miR-133a, miR-328, TGF-beta1, and CTGF. +other 30470910 hsa-mir-21 Fibrosis Treatment with doxycycline significantly attenuated CIH-induced atrial fibrosis, improved AF inducibility, and reduced miR-1, miR-21, miR-133a, miR-328, TGF-beta1, and CTGF. +transcription factor target 30470842 hsa-mir-152 Lymphoma, Non-Hodgkin Our study demonstrates that miR-152 can inhibit lymphoma growth via suppressing DNMT1-mediated silencing of SOCS3 and SHP-1. +lncRNA target 30470824 hsa-mir-103a Carcinoma, Non-Small-Cell Lung Furthermore, miR-103a-3p inhibited growth and metastasis via effects on the KRAS pathway and epithelial-to-mesenchymal transition in EGFR wild-type NSCLC cell lines, respectively, which substantially reduced EGFR expression and activity. +other 30470799 hsa-mir-346 Alzheimer Disease In addition, miR-346 levels are altered in late-Braak stage AD. Thus, miR-346 plays a role in upregulation of APP in the CNS and participates in maintaining APP regulation of Fe, which is disrupted in late stages of AD. +other 30470587 hsa-mir-708 Sarcoma, Ewing RESULTS: We show that miR5p is downregulated in EWS tissues though no associations with any prognostic features such as HUVOS grade, event or survival were found in our cohort. +lncRNA target 30470570 hsa-mir-6783 Adenocarcinoma of Lung In conclusion, our study revealed that circ_0006427 suppressed lung adenocarcinoma progression through regulating miR3p/DKK1 axis. +circulation_biomarker_prognosis_ns 30470261 hsa-mir-490 Carcinoma, Hepatocellular Moreover, circSLC3A2, predominantly localized in the cytoplasm, exhibited an oncogenic role by sponging miR +lncRNA target 30470250 hsa-mir-181b Carcinoma, Non-Small-Cell Lung CONCLUSIONS This study elucidates an important role of miR-181b in the regulation of CSC-like properties, suggesting a potential therapeutic target for overcoming drug resistance in NSCLC. +other 30469549 hsa-mir-378 Diabetic Nephropathies miR-378i has the potential to predict renal injury in DN. +other 30469088 hsa-mir-124a Depression These data suggested that the downregulation of GR, upregulation of FKBP5, miR-124a, and miR-18a in the prefrontal cortex and hippocampus, and downregulation of miR-511 in the prefrontal cortex were relevant to depressive-like behaviors. +other 30469088 hsa-mir-18a Depression These data suggested that the downregulation of GR, upregulation of FKBP5, miR-124a, and miR-18a in the prefrontal cortex and hippocampus, and downregulation of miR-511 in the prefrontal cortex were relevant to depressive-like behaviors. +other 30469088 hsa-mir-511 Depression These data suggested that the downregulation of GR, upregulation of FKBP5, miR-124a, and miR-18a in the prefrontal cortex and hippocampus, and downregulation of miR-511 in the prefrontal cortex were relevant to depressive-like behaviors. +circulation_biomarker_diagnosis_ns 30468908 hsa-mir-9 Breast Neoplasms This study was designed to examine the expression levels of miR-9 and miR-34a in breast tumor tissue samples and plasma of breast cancer patients, compare their expression pattern between tissue samples and plasma samples of patients and analyze their relationship with tumor clinical features. Thus miR-9 and miR-34a have the capability for distinguishing tumor tissues from healthy tissues and the study of their expression levels in tissue may be used as a biomarker for the diagnosis of breast cancer patients from healthy women. +circulation_biomarker_diagnosis_ns 30468908 hsa-mir-34a Breast Neoplasms This study was designed to examine the expression levels of miR-9 and miR-34a in breast tumor tissue samples and plasma of breast cancer patients, compare their expression pattern between tissue samples and plasma samples of patients and analyze their relationship with tumor clinical features. Thus miR-9 and miR-34a have the capability for distinguishing tumor tissues from healthy tissues and the study of their expression levels in tissue may be used as a biomarker for the diagnosis of breast cancer patients from healthy women. +lncRNA target 30468709 hsa-mir-619 Carcinoma, Hepatocellular In summary, our findings indicated that circZFR may exert carcinogenic role in HCC through regulating miR5p/CTNNB1 axis and activating Wnt/beta-catenin pathway. +other 30468491 hsa-mir-155 Hypertension MiR-155 played a therapeutic effect on hypertension. +other 30468491 hsa-mir-155 Mesangial sclerosis, diffuse MiR-155 played a therapeutic effect on hypertension. +genetics_overexpression_promote 30468483 hsa-mir-10b Leukemia, Myeloid, Acute Meanwhile, miR-10b overexpression decreased the percentage of AML cells in the G0/G1 phase when compared with S phase, and suppressed the apoptosis of AML cells. +lncRNA target 30468480 hsa-mir-497 Carcinoma, Squamous Cell, Cutaneous CONCLUSIONS: MiR-497 was lowly expressed in squamous cell carcinoma tissues and cells, which can participate in the regulation of cell proliferation through FAM114A2, thus promoting the progression of CSCC. +transcription factor target 30468477 hsa-mir-155 Breast Neoplasms Therefore, it is preliminarily believed that miR-155 plays an important role in the proliferation and migration of breast cancer cells via down-regulating the expression of SOCS1 and up-regulating the expression of MMP16. +other 30468474 hsa-mir-375 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: Several genes and miRNAs might be used as markers for LSCC in different tumor stages (e.g., MCM2, EGFR, CDK1, CDK2, hsa-miR3p, hsa-miR-375). +other 30468474 hsa-mir-31 Squamous Cell Carcinoma of Head and Neck CONCLUSIONS: Several genes and miRNAs might be used as markers for LSCC in different tumor stages (e.g., MCM2, EGFR, CDK1, CDK2, hsa-miR3p, hsa-miR-375). +transcription factor target 30468470 hsa-mir-874 Esophageal Squamous Cell Carcinoma 3p could be a new therapeutic target and prognostic marker of ESCC. +genetics_overexpression_promote 30468468 hsa-mir-136 Stomach Neoplasms Transfection and subsequent overexpression of miR-136 in gastric cancer cells significantly promoted apoptosis as evident from DAPI and OA staining. +transcription factor target 30468467 hsa-mir-215 Colorectal Neoplasms 3p improved the 5-Fu sensibility via regulating the expression of CXCR1 in the colorectal cancer cell. +genetics_overexpression_promote 30468466 hsa-mir-193a Carcinoma, Hepatocellular However, BMF overexpression could reverse the effects of miR-193a-5p on the cellular functions of HCC cells. +genetics_overexpression_promote 30468464 hsa-mir-214 Pancreatic Carcinoma CONCLUSIONS: Overexpressing miR +lncRNA target 30468463 hsa-mir-485 Osteosarcoma 5p in OA by targeting CX3CL1, indicating that miR +lncRNA target 30468462 hsa-mir-1 Osteosarcoma CONCLUSIONS: MiR-31 inhibits osteosarcoma cell proliferation, migration, and invasion by targeting PICK3C2A. +lncRNA target 30468455 hsa-mir-106a Tibial Fractures Healthy male Sprague-Dawly (SD) rats were randomly divided into three groups, including bone fracture group established as rat tibial fracture model, negative control group implanted by autologous oxygen release nano bionic scaffold composite miR-106a scramble BMSCs, and miR-106a inhibitor group implanted by autologous oxygen release nano bionic scaffold composite miR-106a inhibitor BMSCs. +lncRNA target 30468455 hsa-mir-106a Fractures, Bone Healthy male Sprague-Dawly (SD) rats were randomly divided into three groups, including bone fracture group established as rat tibial fracture model, negative control group implanted by autologous oxygen release nano bionic scaffold composite miR-106a scramble BMSCs, and miR-106a inhibitor group implanted by autologous oxygen release nano bionic scaffold composite miR-106a inhibitor BMSCs. +circulation_biomarker_diagnosis_up 30468285 hsa-mir-17 Diabetic Retinopathy We can conclude that serum miR-20b, miR +circulation_biomarker_diagnosis_ns 30467971 hsa-mir-29 Diabetic Retinopathy Proliferative DR was inversely associated with plasma levels of miR-29b (unadjusted OR = 0.694, 95% CI: 0.535-0.900, P = 0.006) and miR-200b (unadjusted OR = 0.797, 95% CI: 0.637-0.997, P = 0.047). +circulation_biomarker_diagnosis_ns 30467971 hsa-mir-200b Diabetic Retinopathy Proliferative DR was inversely associated with plasma levels of miR-29b (unadjusted OR = 0.694, 95% CI: 0.535-0.900, P = 0.006) and miR-200b (unadjusted OR = 0.797, 95% CI: 0.637-0.997, P = 0.047). +genetics_overexpression_promote 30467970 hsa-mir-296 Diabetes Mellitus RESULTS: Overexpression of miR +lncRNA target 30467955 hsa-mir-15a Pituitary Neoplasms MiR-15a/16 as a tumour-suppressive gene is down-regulated in several tumours, such as chronic lymphocytic leukaemia, pituitary adenomas and prostate carcinoma. +lncRNA target 30467955 hsa-mir-15a Prostatic Neoplasms MiR-15a/16 as a tumour-suppressive gene is down-regulated in several tumours, such as chronic lymphocytic leukaemia, pituitary adenomas and prostate carcinoma. +lncRNA target 30467776 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck LncRNA CASC2 expression vectors were transfected into cells of human OSCC cell lines, and the effects on cancer cell proliferation and miRNA-21 expression were analyzed by CCK-8 assay and RT-qPCR, respectively. CONCLUSIONS: We, therefore, conclude that downregulation of lncRNA CASC2 may participate in the postoperative local recurrence of early OSCC through miRNA-21. +lncRNA target 30467667 hsa-mir-96 Breast Neoplasms In consequence, curcumin treatment for 48 h, prevented autocrine GH-triggered invasion-metastasis, EMT activation through inhibiting NF-kappaB signaling and miR +lncRNA target 30467667 hsa-mir-182 Breast Neoplasms In consequence, curcumin treatment for 48 h, prevented autocrine GH-triggered invasion-metastasis, EMT activation through inhibiting NF-kappaB signaling and miR +lncRNA target 30467667 hsa-mir-183 Breast Neoplasms In consequence, curcumin treatment for 48 h, prevented autocrine GH-triggered invasion-metastasis, EMT activation through inhibiting NF-kappaB signaling and miR +circulation_biomarker_diagnosis_ns 30467642 hsa-mir-101 Hepatolenticular Degeneration In this study, we have measured the absorbed dose using -H2AX, gene (GADD45A, FDXR, and CDKN1A) and miRNA-101 expression in blood samples of cancer patients (n=20) who had undergone partial-body radiotherapy and compared with the derived equivalent whole-body doses (EWBD). However, the estimated dose significantly varied among the subjects and showed poor correlation (r2=0.09, 0.04, 0.01 and 0.03 for GADD45A, FDXR, CDKN1A and miRNA-101, respectively) with EWBD. +transcription factor target 30467286 hsa-mir-542 Silicotuberculosis 5p might be a new therapeutic target for silicosis or other pulmonary fibrosis. +other 30467011 hsa-mir-23b Nephrosis, Lipoid Fifteen miRNAs were selected for further investigation, of which 5 (miR5p, miR-146b-5p, miR-378a-3p, miR-23b-3p and miR-30a-5p) were verified by RT-qPCR to be significantly and steadily increased in NS (> 3-fold, P<.01) and markedly reduced during the clinical remission period (P<.001). +other 30467011 hsa-mir-378a Nephrosis, Lipoid Fifteen miRNAs were selected for further investigation, of which 5 (miR5p, miR-146b-5p, miR-378a-3p, miR-23b-3p and miR-30a-5p) were verified by RT-qPCR to be significantly and steadily increased in NS (> 3-fold, P<.01) and markedly reduced during the clinical remission period (P<.001). +other 30467011 hsa-mir-194 Nephrosis, Lipoid Fifteen miRNAs were selected for further investigation, of which 5 (miR5p, miR-146b-5p, miR-378a-3p, miR-23b-3p and miR-30a-5p) were verified by RT-qPCR to be significantly and steadily increased in NS (> 3-fold, P<.01) and markedly reduced during the clinical remission period (P<.001). +other 30467011 hsa-mir-146b Nephrosis, Lipoid Fifteen miRNAs were selected for further investigation, of which 5 (miR5p, miR-146b-5p, miR-378a-3p, miR-23b-3p and miR-30a-5p) were verified by RT-qPCR to be significantly and steadily increased in NS (> 3-fold, P<.01) and markedly reduced during the clinical remission period (P<.001). +other 30466095 hsa-mir-520c Leukemia, Myeloid, Acute Furthermore, bioinformatics online programs predicted and luciferase reporter assay were used to validate the association of HOXA-AS2 and miR-520c-3p in AML. +lncRNA target 30466075 hsa-mir-33a Osteosarcoma Bioinformatics analysis indicated that the CYR61 3'UTR harbored a potential miR-33a binding site and luciferase reporter assay demonstrated that CYR61 was a target of miR-33a in osteosarcoma cells. CONCLUSION: Our findings suggest lovastatin suppresses osteosarcoma cell invasion through the SREBP-2/miR-33a/CYR61 pathway. +transcription factor target 30466006 hsa-mir-223 Chemical and Drug Induced Liver Injury The miR-223, a negative regulator of keap1, represents an attractive therapeutic target in hepatic injury in T2DM. +transcription factor target 30466006 hsa-mir-233 Diabetes Mellitus, Type 2 As a promising new target, miR-233 may regulate oxidative stress by targeting keap1-Nrf2 system to affect the pathological process of liver injury in T2DM. +transcription factor target 30466006 hsa-mir-233 Chemical and Drug Induced Liver Injury As a promising new target, miR-233 may regulate oxidative stress by targeting keap1-Nrf2 system to affect the pathological process of liver injury in T2DM. +transcription factor target 30466006 hsa-mir-223 Diabetes Mellitus, Type 2 EA ameliorates oxidative stress and insulin resistance via miR +transcription factor target 30465949 hsa-mir-145 Epilepsy Compared with the N group, the target quadrant time and platform crossing times were reduced and the expression of miR-145 and Caspase-9 was increased in the epilepsy groups (P < 0.05). +other 30465521 hsa-mir-125a Atrial Fibrillation Nonetheless, coronary artery calcification (CAC) was associated with higher levels of miRNAs-103, -125a-5p, -221 and -223 in men. +circulation_biomarker_diagnosis_ns 30465521 hsa-mir-27a Atrial Fibrillation In women, CAC was associated with higher plasma levels of miRNA-27a and miRNA-126 and correlated with Agatston scores. +circulation_biomarker_diagnosis_ns 30465521 hsa-mir-126 Atrial Fibrillation In women, CAC was associated with higher plasma levels of miRNA-27a and miRNA-126 and correlated with Agatston scores. +other 30465521 hsa-mir-103 Atrial Fibrillation Nonetheless, coronary artery calcification (CAC) was associated with higher levels of miRNAs-103, -125a-5p, -221 and -223 in men. +other 30465521 hsa-mir-221 Atrial Fibrillation Nonetheless, coronary artery calcification (CAC) was associated with higher levels of miRNAs-103, -125a-5p, -221 and -223 in men. +other 30465521 hsa-mir-223 Atrial Fibrillation Nonetheless, coronary artery calcification (CAC) was associated with higher levels of miRNAs-103, -125a-5p, -221 and -223 in men. +circulation_biomarker_diagnosis_ns 30465521 hsa-mir-212 Atrial Fibrillation Within the total population, ascending Aortic Calcification (AsAC) patients displayed increased plasma levels of miRNA-221, while women, in particular, demonstrated a Descending Aorta Calcification (DAC) associated increase in miRNA-212 levels. +genetics_knock down_suppress 30465177 hsa-mir-155 Carcinoma, Hepatocellular Knockdown of miR-155 in HCC cells attenuated the promotion of tube formation by exosomes under hypoxia in HUVECs, and high expression of exosomal miR-155 in preoperative plasma was significantly correlated with early recurrence. +transcription factor target 30465089 hsa-mir-195 Osteoarthritis These results suggested that miR-195 is involved in the pathogenesis of OA via PTHrP. +lncRNA target 30465046 hsa-mir-21 Herpes Simplex sensitive expression of a dominant-negative inhibitor of HSV replication allows preferential destruction of tumor cells in vitro. +other 30465046 hsa-mir-21 Neoplasms by Histologic Type We have explored a feature that is shared by many tumor types, the up-regulation of miR-21, as a means to generate an oncolytic herpes simplex virus (HSV) that is applicable to a broad range of cancers. +genetics_GWAS 30464631 hsa-mir-143 Leukemia, Myeloid, Accelerated Phase This study investigated epigenetic regulation of HOTAIR and its target microRNA, miR-143, in advanced CML. RESULT: As measured by qPCR, HOTAIR expression in K562 cells, KCL22 cells, and samples from cases of advanced-stage CML increased with levels of several DNA methyltransferases and histone deacetylates, including DNMT1, DNMT3A, HDAC1, EZH2, and LSD1, and miR-143 levels were decreased and HOTAIR levels were increased. +genetics_overexpression_promote 30464616 hsa-mir-588 Stomach Neoplasms EIF5A2 was overexpressed in GC tissue samples, and the expression of miR-588 was inversely correlated to the levels of EIF5A2. +transcription factor target 30464522 hsa-mir-645 Triple Negative Breast Neoplasms This targeting was confirmed by western blot experiments and miR-645 lentiviral particle (LV-645) transduction that inhibited uPA expression in MDA-MB-231 TNBC cells. +lncRNA target 30464520 hsa-mir-30 Carcinoma, Non-Small-Cell Lung 5p reversed the inhibitory effect of PCAT6 on NSCLC cell growth, migration, and invasion. +other 30464258 hsa-mir-21 Pancreatic Carcinoma Here, we demonstrated that miR-21 expression was induced by EGF in pancreatic cancer cells. Furthermore, miR-21 and Spry2 were significantly related to clinical features and may be valuable predictors of PDAC patient prognosis. +lncRNA target 30464170 hsa-mir-203 Stomach Neoplasms ZEB2 axis may provide an informative biomarker of malignancy and a highly selective anti-GC therapeutic target. +genetics_GWAS 30464116 hsa-mir-138 Aortic Valve Disease MiR-138 overexpression inhibited VIC osteogenic differentiation in vitro, while down-regulation of miR-138 enhanced the process. +lncRNA target 30463687 hsa-mir-98 Urinary Bladder Neoplasms In conclusion, our study demonstrates that miR-98 targets LASS2 and regulates bladder cancer chemoresistance through modulation of mitochondrial function. +transcription factor target 30463609 hsa-mir-29b-1 ankylosing spondylitis 1 5p mimic could inhibit the IL +lncRNA target 30463570 hsa-mir-34a Thyroid Neoplasms Based on online database and online tool prediction results, miR-34a was underexpressed in thyroid cancer and might be a direct target of XIST. In thyroid cancer tissues, MET mRNA and protein levels of MET were up-regulated; MET was positively correlated with XIST while negatively correlated with miR-34a, further confirming that XIST serves as a ceRNA for miR-34a through sponging miR-34a, competing with MET for miR-34a binding, and finally modulating thyroid cancer cell proliferation and tumor growth. +circulation_biomarker_diagnosis_up 30463275 hsa-mir-25 Multiple Sclerosis 3p) were significantly upregulated in PedMS and AOMS patients, suggesting that they may be considered circulating biomarkers distinctive of the disease independently from age. +circulation_biomarker_diagnosis_up 30463275 hsa-mir-125a Multiple Sclerosis 3p) were significantly upregulated in PedMS and AOMS patients, suggesting that they may be considered circulating biomarkers distinctive of the disease independently from age. +circulation_biomarker_diagnosis_up 30463275 hsa-mir-20a Multiple Sclerosis 3p) were significantly upregulated in PedMS and AOMS patients, suggesting that they may be considered circulating biomarkers distinctive of the disease independently from age. +circulation_biomarker_diagnosis_up 30463275 hsa-mir-942 Multiple Sclerosis 3p) were significantly upregulated in PedMS and AOMS patients, suggesting that they may be considered circulating biomarkers distinctive of the disease independently from age. +transcription factor target 30463081 hsa-mir-138 Diabetes, Gestational We aimed to identify the dysregulated miRNAs and the corresponding mRNA targets through an integrated miRNA and mRNA transcriptomic profiles analysis and investigate the role of differentially expressed miR +genetics_knock down_promote 30463064 hsa-mir-1290 Carcinoma, Pancreatic Ductal The synergist effect of miR-1290 on the proliferation and metastasis of PDAC cells was attenuated and enhanced by IKK1 overexpression and knockdown, respectively. +other 30462772 hsa-mir-133a Osteosarcoma To conclude, APS repressed proliferation, migration, and invasion while induced apoptosis of OS MG63 cells by up-regulating miR-133a and then inactivating JNK pathway. +lncRNA target 30462625 hsa-mir-339 Lung Neoplasms 5p has potential therapeutic value by sensitizing lung cancer cells to radiation via targeting of PRL-1. +genetics_overexpression_promote 30462539 hsa-mir-146a Carcinoma, Hepatocellular In addition, miR-146a-5p overexpression suppresses cell proliferation and enhances radiosensitivity and cell apoptosis in HCC cells. +transcription factor target 30462536 hsa-mir-424 Hypoxia Moreover, miR-429 and miR5p inhibit proliferation of PASMCs by downregulating CaSR, resulting in reduced Ca(2+) influx under both normoxia and hypoxia. +transcription factor target 30462536 hsa-mir-429 Hypoxia Moreover, miR-429 and miR5p inhibit proliferation of PASMCs by downregulating CaSR, resulting in reduced Ca(2+) influx under both normoxia and hypoxia. +genetics_overexpression_promote 30461333 hsa-mir-96 Urinary Bladder Neoplasms MEG3 overexpression resulted in miR-96 downregulation along with TPM1 upregulation, which inhibited cell proliferation and cell cycle but promoted cell apoptosis of bladder urothelial carcinoma cells in vitro, and at the same time inhibited tumor growth in vivo. +transcription factor target 30461189 hsa-mir-145 Hyperplasia In vivo tests suggested that dual-loading with miR-126 and miR-145 in the bilayered electrospun membranes could modulate both VECs and VSMCs for rapid endothelialization and hyperplasia inhibition as well. +transcription factor target 30461189 hsa-mir-126 Hyperplasia In vivo tests suggested that dual-loading with miR-126 and miR-145 in the bilayered electrospun membranes could modulate both VECs and VSMCs for rapid endothelialization and hyperplasia inhibition as well. +circulation_biomarker_diagnosis_ns 30461074 hsa-mir-150 Hyperglycemia 5p is increased in human islet graft and in the circulation during islet xenograft rejection and beta-cell destruction prior to hyperglycemia and may be an early biomarker for islet xenograft rejection. +genetics_knock down_suppress 30459436 hsa-mir-205 Melanoma Our in vitro findings demonstrate that loss of miR-205 potentiates the invasive ability of melanoma cells. +other 30459436 hsa-mir-125b Melanoma Downregulation of intratumoral expression of miR-205, miR-200c and miR-125b in primary human cutaneous melanomas predicts shorter survival. +other 30459436 hsa-mir-200c Melanoma Downregulation of intratumoral expression of miR-205, miR-200c and miR-125b in primary human cutaneous melanomas predicts shorter survival. +genetics_GWAS 30459357 hsa-mir-155 Ataxia Neuropathy Spectrum Interestingly, c-Kit expression is high when miR-155 is overexpressed, indicating further cooperation between miR-155 and c-Kit. +lncRNA target 30459282 hsa-mir-27a Rhabdomyosarcoma This reexpression of miR-27a led to PAX3:FOXO1 mRNA destabilization and chemotherapy sensitization in aRMS cells in culture and in vivo. Together, these results implicate an HDAC3-SMARCA4-miR-27a-PAX3:FOXO1 circuit as a driver of chemoresistant aRMS and suggest that targeting this pathway with entinostat may be therapeutically effective in patients. +exosome 30458987 hsa-mir-214 Carcinoma, Non-Small-Cell Lung Our results are the first to show that exosomes derived from gefitinib-resistant PC-9GR cells could transfer resistance to its recipient sensitive PC-9 cells, which might be mediated by exosomal transfer of miR-214. +circulation_biomarker_diagnosis_up 30458743 hsa-mir-155 Paget Disease, Extramammary Among these miRNAs, the expression of miR-155 was significantly increased (p < 0.01) in the EMPD patients as compared with that of the health volunteers and the eczema of scrotum or the tinea cruris patients (no difference between these two control groups). CONCLUSION: The serum miRNA expression of gene miR-155 in the EMPD patients was differentiated from that of other subjects warranting further validation of miR-155 as a diagnostic marker of EMPD. +lncRNA target 30458455 hsa-mir-133 Carcinoma, Non-Small-Cell Lung CONCLUSION: Our study indicated that miR-133a might act as a tumor suppressor and be a valuable independent prognostic and diagnostic biomarker for NSCLC, and NSCLC patients with high expression of miR-133 might have a better prognosis. +lncRNA target 30458455 hsa-mir-133a Carcinoma, Non-Small-Cell Lung CONCLUSION: Our study indicated that miR-133a might act as a tumor suppressor and be a valuable independent prognostic and diagnostic biomarker for NSCLC, and NSCLC patients with high expression of miR-133 might have a better prognosis. +circulation_biomarker_prognosis_ns 30458449 hsa-mir-222 Pancreatic Carcinoma CONCLUSION: Tumor-generated exosomes could promote invasion and proliferation of neighboring tumor cells via miR-222 transmission, the plasma exosomal miR-222 plays important roles and may be a useful prognostic maker in PDAC. +lncRNA target 30458442 hsa-mir-1 Urinary Bladder Neoplasms 3p might represent a novel therapeutic target for the treatment of bladder cancer. +lncRNA target 30458344 hsa-mir-122 Myocardial Infarction in vivo investigation revealed that, MI rats administrated with LBPs decreased infarct size and improved cardiac function via down-regulation of miR-122. +genetics_overexpression_promote 30458288 hsa-mir-18b Colorectal Neoplasms 5p, miR-181a-5p, miR-18a-5p and miR-18b-5p) were significantly overexpressed in CRC compared with NCs. +genetics_overexpression_promote 30458288 hsa-mir-103a Colorectal Neoplasms 5p, miR-181a-5p, miR-18a-5p and miR-18b-5p) were significantly overexpressed in CRC compared with NCs. +genetics_overexpression_promote 30458288 hsa-mir-17 Colorectal Neoplasms 5p, miR-181a-5p, miR-18a-5p and miR-18b-5p) were significantly overexpressed in CRC compared with NCs. +genetics_overexpression_promote 30458288 hsa-mir-181a Colorectal Neoplasms 5p, miR-181a-5p, miR-18a-5p and miR-18b-5p) were significantly overexpressed in CRC compared with NCs. +genetics_overexpression_promote 30458288 hsa-mir-18a Colorectal Neoplasms 5p, miR-181a-5p, miR-18a-5p and miR-18b-5p) were significantly overexpressed in CRC compared with NCs. +genetics_overexpression_promote 30458288 hsa-mir-127 Colorectal Neoplasms 5p, miR-181a-5p, miR-18a-5p and miR-18b-5p) were significantly overexpressed in CRC compared with NCs. +circulation_biomarker_diagnosis_ns 30457847 hsa-mir-423 Diabetes Mellitus 5p), were found to be significantly correlated with plasma MAs. +circulation_biomarker_diagnosis_ns 30457847 hsa-mir-142 Cardiovascular Diseases 5p), were found to be significantly correlated with plasma MAs. +circulation_biomarker_diagnosis_ns 30457847 hsa-mir-142 Diabetes Mellitus 5p), were found to be significantly correlated with plasma MAs. +circulation_biomarker_diagnosis_ns 30457847 hsa-mir-423 Cardiovascular Diseases 5p), were found to be significantly correlated with plasma MAs. +other 30457256 hsa-mir-21 esophagus adenocarcinoma The research assessed an expression of microRNA-21 in 25 patients with different degree of metaplasia and dysplasia of mucous coat of esophagus. +genetics_knock down_promote 30457164 hsa-mir-204 Breast Neoplasms In vivo experiments showed that knockdown of DSCAM-AS1 decreased the tumorigenesis of BC cells, increased the expression of miR +other 30456659 hsa-mir-135a Liver Neoplasms In addition, miR-135a hepatic abundance is upregulated by HCV infection in both cultured hepatocytes and human liver, likely mediating a more favorable environment for viral replication and possibly contributing to HCV-induced liver malignancy. +other 30456659 hsa-mir-135a Hepatitis C In addition, miR-135a hepatic abundance is upregulated by HCV infection in both cultured hepatocytes and human liver, likely mediating a more favorable environment for viral replication and possibly contributing to HCV-induced liver malignancy. +lncRNA target 30456527 hsa-mir-326 Lupus Erythematosus, Systemic CONCLUSIONS: Our results suggest that miR-326 might promote B cells differentiation by targeting Ets-1, a negative regulator of B cells differentiation and therefore participate in the pathogenesis of SLE. +transcription factor target 30456455 hsa-mir-132 Arthritis, Rheumatoid These results showed that Schwann cells were protected by miR5p from inflammatory damage by targeting REST/miR-132 pathway, which could provide new targets for treatment of RA-induced peripheral neuropathy. +transcription factor target 30456455 hsa-mir-132 Peripheral Nervous System Diseases These results showed that Schwann cells were protected by miR5p from inflammatory damage by targeting REST/miR-132 pathway, which could provide new targets for treatment of RA-induced peripheral neuropathy. +transcription factor target 30455267 hsa-mir-21 Neuralgia The present study reveals a previously unknown role of TLR8 in the maintenance of neuropathic pain, suggesting that miRTLR8 signaling may be potential new targets for drug development against this type of chronic pain. +other 30455250 hsa-mir-486 Infertility, Male Our data demonstrate that Chd1l-miRMMP2 is a novel regulatory axis governing SSC stemness gene expression and growth properties, offering a novel therapeutic opportunity for treating male infertility. +genetics_overexpression_promote 30455125 hsa-mir-873 Colorectal Neoplasms 5p overexpression in colorectal cancer progression. +other 30455104 hsa-mir-28 Carcinoma, Non-Small-Cell Lung 5p were shown in tumor than normal tissues of lung squamous cell carcinoma patients (all p<0.05). +other 30455104 hsa-mir-28 Lung Neoplasms 5p. +other 30455104 hsa-mir-24 Lung Neoplasms 5p. +other 30455104 hsa-mir-24 Carcinoma, Non-Small-Cell Lung 5p were shown in tumor than normal tissues of lung squamous cell carcinoma patients (all p<0.05). +lncRNA target 30455080 hsa-mir-93 Urinary Bladder Neoplasms Inhibition of miR-93 suppressed the proliferation and invasion of BC cells. +lncRNA target 30454973 hsa-mir-196b Squamous Cell Carcinoma of Head and Neck OBJECTIVE: To explore the effect of miR-196bon the biological features of human laryngeal squamous cell carcinoma (LSCC) through targeting PCDH-17. +other 30454964 hsa-mir-4485 Myelodysplastic Syndromes The miRNA profile showed that mir-28 and mir-LETD7 were under expressed whilst mir-584J and mir-4485 were over expressed in MV from MDS. +other 30454964 hsa-mir-28 Myelodysplastic Syndromes The miRNA profile showed that mir-28 and mir-LETD7 were under expressed whilst mir-584J and mir-4485 were over expressed in MV from MDS. +other 30454964 hsa-let-7d Myelodysplastic Syndromes The miRNA profile showed that mir-28 and mir-LETD7 were under expressed whilst mir-584J and mir-4485 were over expressed in MV from MDS. +other 30454964 hsa-mir-584j Myelodysplastic Syndromes The miRNA profile showed that mir-28 and mir-LETD7 were under expressed whilst mir-584J and mir-4485 were over expressed in MV from MDS. +lncRNA target 30454897 hsa-mir-124 Diabetic Angiopathies Targeting circHIPK3-miR-124 pathway could potentially be a novel approach for the treatment of diabetic-associated vascular injury. +lncRNA target 30454897 hsa-mir-124 Hyperglycemia Further, circHIPK3 downregulation by HG caused microRNA-124 (miR-124) accumulation in HUVECs and HAECs. On the contrary, miR-124 inhibition by the adeno-associated virus (AAV)-packed miR-124 inhibitor protected endothelial cells from HG. +lncRNA target 30454897 hsa-mir-124 Diabetes Mellitus Targeting circHIPK3-miR-124 pathway could potentially be a novel approach for the treatment of diabetic-associated vascular injury. +genetics_overexpression_suppress 30454699 hsa-mir-497 Carcinoma, Non-Small-Cell Lung The inhibitory effect of si-lnc-SNHG1 on NSCLC cell proliferation, migration and invasion could be rescued by miR-497 inhibition, while the overexpression of miR-497 could reverse the effect of lnc-SNHG1 overexpression. Furthermore, our study demonstrated that the lnc-SNHG1 regulated the expression of the insulin-like growth factor 1 receptor (IGF1-R) by acting as a sponge of miR-497 in NSCLC. +transcription factor target 30454615 hsa-mir-137 Sexual Dysfunctions, Psychological miR-137 affects vaginal lubrication in female sexual dysfunction by targeting Aquaporin-2. +genetics_knock down_promote 30454026 hsa-mir-146b Thyroid Cancer, Papillary CONCLUSIONS: The increased expression of miR-21 and miR-146b due to loss of DNA methylation in PTC resulted in the disruption of the transcription machinery and biological pathways. +genetics_knock down_promote 30454026 hsa-mir-21 Thyroid Cancer, Papillary CONCLUSIONS: The increased expression of miR-21 and miR-146b due to loss of DNA methylation in PTC resulted in the disruption of the transcription machinery and biological pathways. +genetics_overexpression_promote 30454024 hsa-mir-204 Melanoma Finally, a concomitant decrease in the expression of Sema5A, Bcl-2 and c-Myb proteins was observed in melanoma cells after miR-204 overexpression. CONCLUSION: Overall our data provide evidences supporting the role of Sema5A in melanoma progression and the involvement of Bcl-2, miR-204 and c-Myb in regulating its expression. +exosome 30453861 hsa-mir-1908 Endometriosis MicroRNA sequencing showed 13 exosomal miRNAs (miRNA-1908, -130b, -451a, 5p, -4488, -432, -342, -425, -505, -6508, -145, -365a, and -365b) which are involved in immune alteration and cell proliferation and were differentially expressed in patients with EMT (fold-change /- 2.0). +exosome 30453861 hsa-mir-1908 Peritoneal Diseases MicroRNA sequencing showed 13 exosomal miRNAs (miRNA-1908, -130b, -451a, 5p, -4488, -432, -342, -425, -505, -6508, -145, -365a, and -365b) which are involved in immune alteration and cell proliferation and were differentially expressed in patients with EMT (fold-change /- 2.0). +lncRNA target 30453824 hsa-mir-122 Placental Insufficiency We previously showed that microRNA-122 inhibition of Cyp7a1 translation decreased cholesterol catabolism to bile acids in female IUGR rats at the time of weaning. We hypothesized that UPI would increase cholesterol and microRNA-122 and decrease Cyp7a1 protein and hepatic bile acids in young adult female IUGR rats. +lncRNA target 30453308 hsa-mir-205 Osteosarcoma Moreover, rescue assays proved that the effects of SNHG16 on the proliferation of osteosarcoma cells were dependent on miR-205. In addition, SNHG16, miR-205, and ZEB1 interact in a common pathway during the development and occurrence of osteosarcoma, providing novel targets for intervention in the treatment of osteosarcoma. +transcription factor target 30453253 hsa-mir-451a Cardiotoxicity Bioinformatics prediction analysis performed on miR-34a-5p and miR-451a identified several putative targets presenting no significant association with cardiotoxicity. Our results indicate a strong association of miR-34a-5p and miR-451a to DOX-induced cardiotoxicity. +transcription factor target 30453253 hsa-mir-34a Cardiotoxicity Bioinformatics prediction analysis performed on miR-34a-5p and miR-451a identified several putative targets presenting no significant association with cardiotoxicity. Our results indicate a strong association of miR-34a-5p and miR-451a to DOX-induced cardiotoxicity. +genetics_GWAS 30453118 hsa-mir-142 Uremia 3p was negatively associated with carotid-femoral pulse-wave velocity in CKD 5D patients. +genetics_GWAS 30453065 hsa-mir-28 Myopia We did not find the association between expression of mir-328 in the peripheral blood cells and PAX6 gene (rs662702) polymorphism comparing myopia and control groups. +genetics_overexpression_promote 30453063 hsa-mir-608 Stomach Neoplasms Overexpression of FOXO6 attenuated the inhibitory effect of miR-608 on the gastric cancer cell growth. +lncRNA target 30453026 hsa-mir-2 Growth Disorders Injection of miR-2/13/71 agomiRs led to significant decrease of Notch expression as well as markedly reduced levels of Vitellogenin mRNA, suppressed oocyte maturation and impaired ovarian growth. +transcription factor target 30453015 hsa-mir-382 Leukemia, Promyelocytic, Acute 5p modulates the ATRA-induced differentiation of acute promyelocytic leukemia by targeting tumor suppressor PTEN. +transcription factor target 30452907 hsa-mir-199b Heart Diseases Here, we aimed at comparing the in vivo efficacy of different chemistry-based antimiR oligonucleotides to inhibit cardiac expression of miR-199b, a highly promising therapeutic target for the treatment of pressure overload-induced cardiac dysfunction. +genetics_knock down_promote 30452399 hsa-mir-337 Carcinoma, Renal Cell 3p, and overexpression of miR +other 30452398 hsa-mir-210 Breast Neoplasms In addition, let-7f,miR-126, miR-210 and miR-378 levels negatively correlated with cTnI expression, and let-7f and miR-130a expressions reversely correlated with NT-proBNP level.CONLUSIONS: miR5p and miR-20a could be served as biomarkers for lower cardiotoxicity induced by EC-D neoadjuvant chemotherapy in BC patients. +other 30452398 hsa-mir-17 Cardiotoxicity In addition, let-7f,miR-126, miR-210 and miR-378 levels negatively correlated with cTnI expression, and let-7f and miR-130a expressions reversely correlated with NT-proBNP level.CONLUSIONS: miR5p and miR-20a could be served as biomarkers for lower cardiotoxicity induced by EC-D neoadjuvant chemotherapy in BC patients. +other 30452398 hsa-let-7f Breast Neoplasms In addition, let-7f,miR-126, miR-210 and miR-378 levels negatively correlated with cTnI expression, and let-7f and miR-130a expressions reversely correlated with NT-proBNP level.CONLUSIONS: miR5p and miR-20a could be served as biomarkers for lower cardiotoxicity induced by EC-D neoadjuvant chemotherapy in BC patients. +other 30452398 hsa-mir-20a Cardiotoxicity In addition, let-7f,miR-126, miR-210 and miR-378 levels negatively correlated with cTnI expression, and let-7f and miR-130a expressions reversely correlated with NT-proBNP level.CONLUSIONS: miR5p and miR-20a could be served as biomarkers for lower cardiotoxicity induced by EC-D neoadjuvant chemotherapy in BC patients. +other 30452398 hsa-mir-20a Breast Neoplasms In addition, let-7f,miR-126, miR-210 and miR-378 levels negatively correlated with cTnI expression, and let-7f and miR-130a expressions reversely correlated with NT-proBNP level.CONLUSIONS: miR5p and miR-20a could be served as biomarkers for lower cardiotoxicity induced by EC-D neoadjuvant chemotherapy in BC patients. +other 30452398 hsa-mir-130a Breast Neoplasms In addition, let-7f,miR-126, miR-210 and miR-378 levels negatively correlated with cTnI expression, and let-7f and miR-130a expressions reversely correlated with NT-proBNP level.CONLUSIONS: miR5p and miR-20a could be served as biomarkers for lower cardiotoxicity induced by EC-D neoadjuvant chemotherapy in BC patients. +other 30452398 hsa-mir-17 Breast Neoplasms In addition, let-7f,miR-126, miR-210 and miR-378 levels negatively correlated with cTnI expression, and let-7f and miR-130a expressions reversely correlated with NT-proBNP level.CONLUSIONS: miR5p and miR-20a could be served as biomarkers for lower cardiotoxicity induced by EC-D neoadjuvant chemotherapy in BC patients. +other 30452398 hsa-let-7f Cardiotoxicity In addition, let-7f,miR-126, miR-210 and miR-378 levels negatively correlated with cTnI expression, and let-7f and miR-130a expressions reversely correlated with NT-proBNP level.CONLUSIONS: miR5p and miR-20a could be served as biomarkers for lower cardiotoxicity induced by EC-D neoadjuvant chemotherapy in BC patients. +other 30452398 hsa-mir-130a Cardiotoxicity In addition, let-7f,miR-126, miR-210 and miR-378 levels negatively correlated with cTnI expression, and let-7f and miR-130a expressions reversely correlated with NT-proBNP level.CONLUSIONS: miR5p and miR-20a could be served as biomarkers for lower cardiotoxicity induced by EC-D neoadjuvant chemotherapy in BC patients. +other 30452398 hsa-mir-210 Cardiotoxicity In addition, let-7f,miR-126, miR-210 and miR-378 levels negatively correlated with cTnI expression, and let-7f and miR-130a expressions reversely correlated with NT-proBNP level.CONLUSIONS: miR5p and miR-20a could be served as biomarkers for lower cardiotoxicity induced by EC-D neoadjuvant chemotherapy in BC patients. +other 30452398 hsa-mir-378 Cardiotoxicity In addition, let-7f,miR-126, miR-210 and miR-378 levels negatively correlated with cTnI expression, and let-7f and miR-130a expressions reversely correlated with NT-proBNP level.CONLUSIONS: miR5p and miR-20a could be served as biomarkers for lower cardiotoxicity induced by EC-D neoadjuvant chemotherapy in BC patients. +other 30452398 hsa-mir-126 Cardiotoxicity In addition, let-7f,miR-126, miR-210 and miR-378 levels negatively correlated with cTnI expression, and let-7f and miR-130a expressions reversely correlated with NT-proBNP level.CONLUSIONS: miR5p and miR-20a could be served as biomarkers for lower cardiotoxicity induced by EC-D neoadjuvant chemotherapy in BC patients. +other 30452398 hsa-mir-126 Breast Neoplasms In addition, let-7f,miR-126, miR-210 and miR-378 levels negatively correlated with cTnI expression, and let-7f and miR-130a expressions reversely correlated with NT-proBNP level.CONLUSIONS: miR5p and miR-20a could be served as biomarkers for lower cardiotoxicity induced by EC-D neoadjuvant chemotherapy in BC patients. +other 30452398 hsa-mir-378 Breast Neoplasms In addition, let-7f,miR-126, miR-210 and miR-378 levels negatively correlated with cTnI expression, and let-7f and miR-130a expressions reversely correlated with NT-proBNP level.CONLUSIONS: miR5p and miR-20a could be served as biomarkers for lower cardiotoxicity induced by EC-D neoadjuvant chemotherapy in BC patients. +lncRNA target 30452299 hsa-mir-130 Stomach Neoplasms CONCLUSION: Taken together, these findings indicate that MRPL39 serves as a tumor suppressor by directly targeting miR-130 in GC, which suggests that it might be a novel biomarker in the diagnosis and prognosis of GC. +lncRNA target 30452118 hsa-mir-146b Endometrial Neoplasms Progesterone exerted suppressive influence on endometrial cancer progression via regulation of lncRNA NEAT1/miR-146b-5p-mediated Wnt/beta-catenin signaling pathway, which might reveal new strategies for developing more effective therapeutics. +transcription factor target 30451820 hsa-mir-194 Colorectal Neoplasms Extensively, our study also showed that SIRT1 is the novel direct target of miR5p in CRC cells. +exosome 30451486 hsa-mir-21 Carcinoma, Non-Small-Cell Lung We used the immuno-biochip to measure the expression of miR-21 microRNA and TTF-1 mRNA in EGFR- or PD-L1-bearing exosomes from human sera and achieved absolute sensitivity and specificity in distinguishing normal controls from non-small cell lung cancer patients. +exosome 30451486 hsa-mir-21 Lung Neoplasms We used the immuno-biochip to measure the expression of miR-21 microRNA and TTF-1 mRNA in EGFR- or PD-L1-bearing exosomes from human sera and achieved absolute sensitivity and specificity in distinguishing normal controls from non-small cell lung cancer patients. +other 30450855 hsa-mir-34a Nerve Degeneration However, the role of miR-34a in sevoflurane-induced hippocampal neurodegeneration remains largely unclear. +transcription factor target 30450855 hsa-mir-34a Memory Disorders miR-34a has been found to negatively regulate ketamine-induced hippocampal apoptosis and memory impairment. RESULTS: Sevoflurane upregulated hippocampal miR-34a, and miR-34a inhibitor attenuated sevoflurane-induced hippocampal apoptosis and memory impairment. +lncRNA target 30450852 hsa-mir-373 Hepatitis C CONCLUSION: miR-373 abrogation reduced HCV replication via activation of type 1 IFN responses by targeting IRF5 in JFH1-infected Huh 7.5 cells, suggesting a promising therapeutic for treating HCV infection. +other 30450635 hsa-mir-144 Chronic Periodontitis CONCLUSION: This re-analysis of miRNA signatures has implied the potential regulatory mechanism of miR5p and its potential for exploring alternative therapeutic approaches, especially those that use miRNA delivery systems to treat chronic periodontitis. +other 30449992 hsa-mir-21 Hypertension, Pulmonary CONCLUSIONS: The expression of systemic and pulmonary miR-21 is associated with the severity of RV dysfunction in patients with hypoxia-induced PH. +other 30449704 hsa-mir-15b Colorectal Neoplasms Here we discovered that miR-15b expression positively correlated with therapeutic outcome in CRC. +lncRNA target 30449595 hsa-mir-98 Reperfusion Injury 5p may play a potential role in cerebral ischemia/reperfusion injury and represents a potential therapeutic target for neuroprotection. +lncRNA target 30449457 hsa-mir-200b Gingival Overgrowth Our results suggested that miR-200b was an upstream effector of the CsA-induced EMT and may act as a therapeutic target for CsA-induced gingival overgrowth. +genetics_overexpression_promote 30449183 hsa-mir-219a Osteosarcoma Furthermore, overexpressed miR-219a-5p significantly repressed OS cell invasion and migration, which was reversed by overexpressed EYA2. +lncRNA target 30448733 hsa-mir-224 Colorectal Neoplasms A large phenotypical and molecularly characterized series of preinvasive and invasive colorectal lesions was investigated for miR-224 expression by qRT-PCR and in situ hybridization. miR-224 targets caspase-3 and caspase-7 in colorectal cancer, and this inverse relation was already evident from the earliest phases of transformation in intestinal mucosa. +genetics_GWAS 30448733 hsa-mir-224 Diarrhea 5, With Tufting Enteropathy, Congenital miR-224 was significantly upregulated during the adenoma-carcinoma sequence and in the context of inflammatory bowel disease dysplastic lesions, whereas its expression was significantly downregulated among BRAF-mutated tumors and in the presence of a DNA mismatch repair deficiency. +genetics_GWAS 30448733 hsa-mir-224 Carcinoma miR-224 was significantly upregulated during the adenoma-carcinoma sequence and in the context of inflammatory bowel disease dysplastic lesions, whereas its expression was significantly downregulated among BRAF-mutated tumors and in the presence of a DNA mismatch repair deficiency. +genetics_GWAS 30448733 hsa-mir-224 Retinoblastoma miR-224 was significantly upregulated during the adenoma-carcinoma sequence and in the context of inflammatory bowel disease dysplastic lesions, whereas its expression was significantly downregulated among BRAF-mutated tumors and in the presence of a DNA mismatch repair deficiency. +genetics_GWAS 30448733 hsa-mir-224 Adenoma miR-224 was significantly upregulated during the adenoma-carcinoma sequence and in the context of inflammatory bowel disease dysplastic lesions, whereas its expression was significantly downregulated among BRAF-mutated tumors and in the presence of a DNA mismatch repair deficiency. +genetics_GWAS 30448733 hsa-mir-224 Turcot syndrome miR-224 was significantly upregulated during the adenoma-carcinoma sequence and in the context of inflammatory bowel disease dysplastic lesions, whereas its expression was significantly downregulated among BRAF-mutated tumors and in the presence of a DNA mismatch repair deficiency. The miR-224/caspases axis may represent an interesting field of study for innovative biomarkers/therapeutics for BRAF-mutated/DNA mismatch repair-deficient tumors. +lncRNA target 30448543 hsa-mir-520f Carcinoma, Hepatocellular Together, these preclinical findings suggest that hypoxia may increase the HCC CSC population via altering the AR/miR-520f-3p/SOX9 signaling, and targeting this newly identified signaling with the small molecule, miR-520f-3p, may help in the development of the novel therapy to better suppress the HCC progression. +lncRNA target 30448056 hsa-mir-409 Carcinoma, Non-Small-Cell Lung Collectively, the results suggested that ZEB1-AS1/miR3p/ZEB1 constitutes a positive feedback loop to promote the tumorigenesis of NSCLC, highlighting the possibility of improving NSCLC treatment by targeting the ZEB1-AS1 signaling pathway. +other 30447962 hsa-mir-145 Varicose Ulcer CONCLUSIONS Local and sustained release of miR-145 by PLGA NPs attenuated intimal hyperplasia in the rabbit model by maintaining VSMCs in a contractile state. +genetics_GWAS 30447914 hsa-mir-149 Colorectal Neoplasms For five miRNAs (miR-196a, miR-146a, miR-27a, miR-499 and miR-149) which we performed a meta-analysis, miR-27a and miR-149 gene polymorphisms were associated with susceptibility to CRC. In conclusion, certain miRNAs (miR-27a and miR-149) may affect the CRC risk and can be regarded as genetic markers amongst different populations. +genetics_GWAS 30447706 hsa-mir-21 Uterine Cervical Neoplasms BACKGROUND: We investigated correlations of miR-21 gene polymorphisms including rs1292037 (A > G) and rs13137 (A > T) with the chemosensitivity to cisplatin plus paclitaxel, and prognosis before cervical cancer (CC) surgery, which may provide a novel target for prevention and treatment of CC. RESULTS: rs1292037 (A > G) locus AG, GG, AG+GG and G allele in miR-21 gene may increase chemoresistance to cisplatin plus paclitaxel in CC. +transcription factor target 30447399 hsa-mir-34 Prostatic Neoplasms Herein, we demonstrated the fabrication of a pH and glutathione (GSH) sensitive nanocarrier for co-delivery of docetaxel (DTX) and rubone (RUB), a miR-34 activator for targeting CSCs, for the treatment of taxane resistant (TXR) prostate cancer. +transcription factor target 30447399 hsa-mir-34a Prostatic Neoplasms Herein, we demonstrated the fabrication of a pH and glutathione (GSH) sensitive nanocarrier for co-delivery of docetaxel (DTX) and rubone (RUB), a miR-34 activator for targeting CSCs, for the treatment of taxane resistant (TXR) prostate cancer. +circulation_biomarker_diagnosis_ns 30447342 hsa-mir-675 Stomach Neoplasms 3p plasma levels were significantly reduced in GC patients (P<0.05). +lncRNA target 30447272 hsa-mir-34a Folic Acid Deficiency Together, the present results indicate that maternal folic acid deficiency stimulates neuronal apoptosis via microRNA-34a associated with Bcl-2 signalling in rat offspring. +circulation_biomarker_diagnosis_ns 30447248 hsa-mir-141 Diabetes Mellitus MiR-27b, miR-141 and miR-191 were decreased in trophoblast cells and in maternal plasma of diabetic rabbits. +circulation_biomarker_diagnosis_ns 30447248 hsa-mir-27b Diabetes Mellitus MiR-27b, miR-141 and miR-191 were decreased in trophoblast cells and in maternal plasma of diabetic rabbits. +circulation_biomarker_diagnosis_ns 30447248 hsa-mir-191 Diabetes Mellitus MiR-27b, miR-141 and miR-191 were decreased in trophoblast cells and in maternal plasma of diabetic rabbits. +other 30447009 hsa-mir-1 Colorectal Neoplasms For stage II disease, 5-year RFS for patients with MIR31HG outlier status was 49% compared to 77% for those with normal-like expression. +transcription factor target 30446578 hsa-mir-24 Lung Injury Here, we profiled the expression of miRs in lung tissues explanted from a lung injury model and examined the effect of nicotine on one of the identified miRs (miR-24) and its downstream targets. Our data show that miR-24 is downregulated during lung injury and is suppressed by nicotine. +genetics_overexpression_promote 30446524 hsa-mir-758 Carcinoma, Non-Small-Cell Lung Our results supported that the overexpression of miR-758 inhibits proliferation, migration, and invasion, and promotes apoptosis of NSCLC cells by negative regulating HMGB2. +other 30446443 hsa-mir-34a Urinary Bladder Neoplasms In the validation phase, miR-34a-3p had a significantly higher expression in tumors of NMIBC patients without recurrence (P=0.0155). CONCLUSIONS: Our data suggest that miR-34a-3p is an independent biomarker of NMIBC recurrence and a promising candidate for further independent validations as an additional factor to improve predictive value of European Organization for Research and Treatment of Cancer nomogram. +other 30446228 hsa-mir-143 Uterine Cervical Neoplasms The miR-143/145 cluster is down-regulated in cervical tumor cells suggesting a role in tumorigenesis including cytoskeleton remodeling, a key event for tumor progression. +other 30446228 hsa-mir-145 Uterine Cervical Neoplasms The miR-143/145 cluster is down-regulated in cervical tumor cells suggesting a role in tumorigenesis including cytoskeleton remodeling, a key event for tumor progression. +genetics_knock down_promote 30445461 hsa-mir-423 Diabetes Mellitus, Type 2 3p were significantly correlated with fat loss ( = 0.45 and 0.43, respectively) and resulted, alone or in combination, in being predictors of fat loss in generalized linear regression models including exercise type as covariate. +genetics_knock down_promote 30445461 hsa-mir-451a Diabetes Mellitus, Type 2 3p were significantly correlated with fat loss ( = 0.45 and 0.43, respectively) and resulted, alone or in combination, in being predictors of fat loss in generalized linear regression models including exercise type as covariate. +transcription factor target 30444938 hsa-mir-218 Periodontitis Collectively, our findings therefore suggest that miR-218 acts as a protective role in periodontitis through the regulation of Mmp9. +other 30444806 hsa-mir-505 Delayed Graft Function 3p as prognostic biomarker for DGF. +lncRNA target 30444423 hsa-mir-382 Pancreatic Carcinoma The circRHOT1 may play a role in pancreatic cancer through binding miR-26b, miR-125a, miR-330 and miR-382 to regulate multiple tumor-associated pathways. +lncRNA target 30444423 hsa-mir-125a Pancreatic Carcinoma The circRHOT1 may play a role in pancreatic cancer through binding miR-26b, miR-125a, miR-330 and miR-382 to regulate multiple tumor-associated pathways. +lncRNA target 30444423 hsa-mir-30 Pancreatic Carcinoma The circRHOT1 may play a role in pancreatic cancer through binding miR-26b, miR-125a, miR-330 and miR-382 to regulate multiple tumor-associated pathways. +lncRNA target 30444423 hsa-mir-26b Pancreatic Carcinoma The circRHOT1 may play a role in pancreatic cancer through binding miR-26b, miR-125a, miR-330 and miR-382 to regulate multiple tumor-associated pathways. +transcription factor target 30444043 hsa-mir-381 Breast Neoplasms In summary, miR-381 could overcome DDP resistance of breast cancer by directly targeting MDR1, providing a novel therapeutic target for breast cancer chemoresistance. +genetics_overexpression_promote 30443973 hsa-mir-130b Squamous Cell Carcinoma of Head and Neck The in vivo assay suggested that the overexpression of miR-130b promoted the growth of ESCC tumours. +lncRNA target 30443961 hsa-mir-342 Colorectal Neoplasms Together, our results reveal a novel pathway that SCARNA2 regulates CRC chemoresistance through targeting miR +lncRNA target 30443959 hsa-mir-129 Breast Neoplasms Our study showed that OIP5-AS1 plays a critical role in promoting breast cancer progression and that OIP5-AS1 downregulation targets SOX2 by miR +circulation_biomarker_diagnosis_up 30443949 hsa-mir-548c Pre-Eclampsia Compared with healthy controls, miR-548c-5p was obviously downregulated in serum exosomes and placental mononuclear cells in patients with preeclampsia. +genetics_overexpression_promote 30443946 hsa-mir-99a Breast Neoplasms Overexpression of miR-99a-5p and decreased expression of CDC25A could suppress breast cancer cell proliferation and invasion and facilitate apoptosis. +other 30443836 hsa-mir-206 Amyotrophic Lateral Sclerosis On the other hand, while the presence of miR-206 in muscle cells delays onset and death in ALS, the relationship between these two phenomena remains unclear. +transcription factor target 30443645 hsa-mir-124 AIDS Dementia Complex Based on these novel findings, it is evident that dysregulation of miR-124 is involved in the pathogenesis of HAND and that restoration of miR-124 could serve as an adjunctive treatment for dampening neuroinflammation associated with HAND. +transcription factor target 30443645 hsa-mir-124-1 AIDS Dementia Complex Based on these novel findings, it is evident that dysregulation of miR-124 is involved in the pathogenesis of HAND and that restoration of miR-124 could serve as an adjunctive treatment for dampening neuroinflammation associated with HAND. +circulation_biomarker_diagnosis_ns 30443558 hsa-let-7a Liver Cirrhosis METHODS: We analyzed circulating let-7a-5p levels in serum and serum-derived extracellular vesicles (EVs) in 84 Japanese CHC patients who underwent a liver biopsy by quantitative real-time polymerase chain reaction, and investigated the association of its levels with histological hepatic fibrotic stage, liver stiffness, and several hepatic fibrotic markers. CONCLUSIONS: These results provide evidence that circulating let-7a-5p in serum may serve as a surrogate marker for severity of hepatic fibrosis in CHC. +circulation_biomarker_diagnosis_ns 30443558 hsa-let-7a Hepatitis C METHODS: We analyzed circulating let-7a-5p levels in serum and serum-derived extracellular vesicles (EVs) in 84 Japanese CHC patients who underwent a liver biopsy by quantitative real-time polymerase chain reaction, and investigated the association of its levels with histological hepatic fibrotic stage, liver stiffness, and several hepatic fibrotic markers. CONCLUSIONS: These results provide evidence that circulating let-7a-5p in serum may serve as a surrogate marker for severity of hepatic fibrosis in CHC. +circulation_biomarker_diagnosis_up 30443183 hsa-mir-186 Cerebral Infarction 5p was upregulated in ischemia stroke patients' serum compared with healthy donors. +other 30443177 hsa-mir-16-1 Cholesteatoma, Middle Ear 1-3p expressed significantly higher while miRNA-10a-5p exhibited an obviously decreased expression in middle ear cholesteatoma tissues when compared with normal skin. +other 30443177 hsa-mir-10a Cholesteatoma, Middle Ear 1-3p expressed significantly higher while miRNA-10a-5p exhibited an obviously decreased expression in middle ear cholesteatoma tissues when compared with normal skin. +other 30443177 hsa-mir-21 Cholesteatoma, Middle Ear 1-3p expressed significantly higher while miRNA-10a-5p exhibited an obviously decreased expression in middle ear cholesteatoma tissues when compared with normal skin. +lncRNA target 30442884 hsa-mir-195 Glioblastoma Mechanistically, further investigation revealed that lncRNA AC003092.1 regulates TFPI-2 expression through miR-195 in GB. Taken together, these data suggest that lncRNA AC003092.1 could inhibit the function of miR-195 by acting as an endogenous CeRNA, leading to increased expression of TFPI-2; this promotes TMZ-induced apoptosis, thereby making GB cells more sensitive to TMZ. +lncRNA target 30442874 hsa-mir-384 Carcinoma, Non-Small-Cell Lung Based on the findings of our study, it was established that miR-384 could down-regulate COL10A1 levels, subsequently inhibiting cell proliferation and promoting cell apoptosis and autophagy in NSCLC cells. +lncRNA target 30442370 hsa-mir-423 Ovarian Neoplasms In conclusion, our findings demonstrated that LINC00319 promotes ovarian cancer progression through upregulating NACC1 expression by restraining miR +lncRNA target 30442369 hsa-mir-15b Urinary Bladder Neoplasms In the meantime, miR-15b-5p directly targeted CCDC19, a tumor suppressor in BCa. In conclusion, this study identified a novel mechanism that MAGI2-AS3/miR-15b-5p/CCDC19 signaling pathway regulates BCa progression. +lncRNA target 30442366 hsa-mir-129 Osteosarcoma 5p and DLK1, can be utilized as factors for the clinical diagnosis and prognosis of osteosarcoma, and may be potential targets for the treatment of osteosarcoma. +other 30442364 hsa-mir-1914 Adenocarcinoma of Lung This study demonstrated that the three-miRNA signature (miR-1293, miR-873 and miR-1914) could be used as a prognostic marker in LACA. +other 30442364 hsa-mir-1293 Adenocarcinoma of Lung This study demonstrated that the three-miRNA signature (miR-1293, miR-873 and miR-1914) could be used as a prognostic marker in LACA. +other 30442364 hsa-mir-873 Adenocarcinoma of Lung This study demonstrated that the three-miRNA signature (miR-1293, miR-873 and miR-1914) could be used as a prognostic marker in LACA. +other 30442352 hsa-mir-181a Obesity Considering the relationship between obesity development and the functions regulated by these two genes, BCL2 and miR-181a could be adopted as potential biomarkers for childhood obesity. +lncRNA target 30442237 hsa-mir-138 Diabetes Mellitus, Type 2 5p contributed to the TNF--induced IR, possibly through inducing autophagy in HepG2 cells by regulating SIRT1. +other 30441870 hsa-mir-375 Carcinoma, Merkel Cell Together, our results suggest dual roles of miR-375 and LDHB in MCPyV and non-MCPyV-associated MCCs. +lncRNA target 30440128 hsa-mir-200c Respiratory Distress Syndrome Conclusion: In ARDS, down-regulation of lncRNA GAS5 decreases ACE2 expression through increasing miR-200c-3p to promote the apoptosis of A549 cells, thus to promote the progression of ARDS. +transcription factor target 30439713 hsa-mir-24 Myocardial Reperfusion Injury 3p could suppress RIPK1 and therefore exert cardioprotective effects in myocardial I/R injury. +lncRNA target 30439707 hsa-mir-139 Ovarian Neoplasms CONCLUSION: Recovery of miR5p suppressed the expression of c-Jun and thus reversed cisplatin-resistance in ovarian cancer. +circulation_biomarker_diagnosis_up 30439699 hsa-mir-124 Myocardial Infarction Although the alteration of miR-124 was confirmed in peripheral blood of MI patients, little is known regarding the biological functions of miR-124 in cardiomyocytes. +transcription factor target 30439502 hsa-mir-200a Glaucoma miR-200a can inhibit the FGF7-mediated MAPK signaling pathway and play a protective role on improving the glaucoma-induced optical nerve injury. +other 30439361 hsa-mir-142 Hypertrophy Enhanced expression of miR-152, miR-212/132 while decreased miR3p expression was observed in hypertrophic condition. +other 30439361 hsa-mir-152 Hypertrophy Enhanced expression of miR-152, miR-212/132 while decreased miR3p expression was observed in hypertrophic condition. +other 30439324 hsa-mir-126 Fibrosis, Renal (2) RT-PCR results: Compared with sham group, the mRNA expressions of miR-126, VEGFA, VEGFR-2 and Notch1 in renal tissues were significantly increased at each time point after operation in UUO model group. Compared with the UUO model group, the mRNA expressions of miR-126, VEGFA, VEGFR-2 and Notch1 in renal tissue of 7 days postoperatively in the middle and high doses Yishen Huoxue prescription group and the losartan group were significantly increased [miR-126 (2(-DeltaDeltaCt)): 0.465+/-0.067, 0.639+/-0.092, 0.404+/-0.069 vs. 0.132+/-0.021; VEGFA (2(-DeltaDeltaCt)): 0.024+/-0.005, 0.027+/-0.007, 0.023+/-0.006 vs. 0.014+/-0.006; VEGFR-2 (2(-DeltaDeltaCt)): 0.021+/-0.007, 0.023+/-0.008, 0.019+/-0.007 vs. 0.012+/-0.004; Notch1 (2(-DeltaDeltaCt)): 0.017+/-0.004, 0.020+/-0.005, 0.018+/-0.005 vs. 0.007+/-0.004; all P < 0.05]; compared with the losartan group, the mRNA expressions of each index in the middle and high doses Yishen Huoxue prescription group were increased at all the time points, but there was no significant difference between them (all P > 0.05). +lncRNA target 30431444 hsa-mir-200c Nasopharyngeal Carcinoma Accordingly, it was concluded that miR-200c exerted a tumor-promoting role in NPC development by targeting DACH1, which may contribute to the increase in the rates of NPC proliferation and migration. +circulation_biomarker_diagnosis_down 30431436 hsa-mir-124 Arthritis, Rheumatoid The measurements of miR-124 and U-6 expression, CRP, anti-CCP, rheumatoid factors (RFs), radiographs of both hands with calculation of total sharp score (TSS), DAS28 and cytokines, chemokines and MMP levels in serum were obtained from all RA patients. +other 30431147 hsa-mir-17 Mycosis Fungoides Specifically, unilesional MF had a higher miR-17 level than early MF and inflammatory dermatoses. +genetics_knock down_suppress 30431124 hsa-mir-940 Glioma Furthermore, KLF9 knockdown was able to rescue the effects of miR940 on glioma cell proliferation and invasion. +genetics_overexpression_promote 30431118 hsa-mir-663 Carcinoma, Renal Cell PAK4 restoration partially attenuated the suppressive roles of miR663 overexpression on the proliferation and invasion of ccRCC cells. +genetics_overexpression_suppress 30431113 hsa-mir-885 Adenocarcinoma of Lung Moreover, we found that Aurora A overexpression or miR8853p inhibition was associated with more aggressive behaviour in LAD cells. +genetics_overexpression_promote 30431107 hsa-mir-584 Pancreatic Carcinoma The restoration of CCND1 expression significantly abolished the inhibitory effects of miR584 overexpression on pancreatic cancer cells. +lncRNA target 30431104 hsa-mir-22 Carcinoma, Renal Cell In conclusion, lncRMALAT1 affected the proliferation and migration of RCC cells by targeting miR223p through the inactivation of the PI3K/Akt signaling pathway. +genetics_overexpression_promote 30431102 hsa-mir-494 Endometrial Neoplasms Furthermore, upregulation of miR4943p in patients with EC indicated poorer prognosis; miR4943p overexpression significantly promoted the proliferation, migration and invasion of HHUA and JEC cells in vitro. +lncRNA target 30431090 hsa-mir-409 Carcinoma, Endometrioid These findings indicated that miR409 targeted the Smad2 transcript and suppressed endometrial cancer cell growth, suggesting that miR409 has a tumor suppressive role in the pathogenesis of human endometrial cancer. +transcription factor target 30431073 hsa-mir-494 Sarcoma, Synovial In vitro experiments confirmed that miR494.3p functioned as a tumour suppressor through the involvement of CXCR4 and ongoing studies are directed to better clarify its role in SS therapeutic strategies. +other 30431065 hsa-mir-214 Liver Diseases In conclusion, MEG3 promoted hepatic insulin resistance by serving as a ceRNA of miR214 to facilitate ATF4 expression. +exosome 30431056 hsa-mir-138 Endometriosis These results suggested that uterine endothelial cells promoted miR138 to induce exosomemediated inflammation and apoptosis in Ems through the VEGF/NFkappaB signaling pathway. +genetics_overexpression_promote 30430633 hsa-mir-141 Diabetic Nephropathies Moreover, miR-141 displayed a negatively regulatory effect on IRS2 abundance, and overexpression of IRS2 reversed the inhibitory effect of miR-141 on development of DN cells ( P < 0.05). +lncRNA target 30430564 hsa-mir-216a Carcinoma, Hepatocellular Finally, the in vivo experiments were used and the data proved that DANCR also strongly suppressed HCC tumor growth in vivo via targeting miR-216a-5p and KLF12. +genetics_GWAS 30430204 hsa-mir-155 Lymphoma, Large B-Cell, Diffuse In EBV-negative DLBCL, CD163/CD68 ratio was higher among advanced-staged/high-tumor burden disease and overexpression of miR-155 was associated with decreased polarization to the M2 phenotype of macrophages. +other 30429351 hsa-mir-221 Lymphoma, Large B-Cell, Diffuse 5p in GCB-DLBCL cells were verified using RIP-Northern blotting. +other 30429351 hsa-let-7c Lymphoma, Large B-Cell, Diffuse 5p in GCB-DLBCL cells were verified using RIP-Northern blotting. +other 30429351 hsa-mir-423 Lymphoma, Large B-Cell, Diffuse 5p in GCB-DLBCL cells were verified using RIP-Northern blotting. +genetics_overexpression_promote 30429236 hsa-mir-135b Thyroid Cancer, Papillary PcDNA3.1-GAS8-AS1 and si-GAS8-AS1, miR-135b-5p mimic and si-CCND2 were transfected into PTC cells. In addition, we also proved that overexpressed GAS8-AS1 inhibited tumor formation in vivo GAS8-AS1 suppresses PTC cell growth through the miR-135b-5p/CCND2 axis. +genetics_overexpression_promote 30429233 hsa-mir-141 Colorectal Neoplasms Furthermore, overexpression of miR-141, targetting MAP4K4, enhanced the effected of 5-FU and suppressed the malignant biological behaviors, in vivo Our findings showed that 5-FU inhibited malignant behavior of human CRC cells in vitro and in vivo by enhancing the efficiency of miR-141 Our data suggested that targetting the miR-141/MAP4K4 signaling pathway could be a potential molecular target that may enhance chemotherapeutic efficacy in the treatment of CRC. +genetics_GWAS 30429231 hsa-mir-130a Coronary Artery Disease AIMS To investigate the relationship between the miR-130a polymorphism rs731384 and coronary artery disease (CAD) and to further explore the molecular mechanism of the pathogenesis of CAD, an observational single-center study was conducted. +lncRNA target 30429229 hsa-mir-133a Colorectal Neoplasms We also found that SOX4 was a downstream target of miR-133a and ABHD11-AS1 subsequently exerted its biological effects via modulating the expression of SOX4 in colorectal cancer cells. Collectively, these findings manifested that the ABHD11-AS1/miR-133a/SOX4 axis may be a cogitable and promising therapeutic target for colorectal cancer. +other 30428976 hsa-mir-21 Prostatic Neoplasms The results of 29 health samples, 18 prostate cancer samples, 23 breast cancer samples imply that miR-141 and miR-21 are up-regulated in the prostate cancer samples and the breast cancer samples, respectively, and as reference miR-16 shows no difference in health and patient samples. +other 30428976 hsa-mir-16 Breast Neoplasms The results of 29 health samples, 18 prostate cancer samples, 23 breast cancer samples imply that miR-141 and miR-21 are up-regulated in the prostate cancer samples and the breast cancer samples, respectively, and as reference miR-16 shows no difference in health and patient samples. +other 30428976 hsa-mir-141 Prostatic Neoplasms The results of 29 health samples, 18 prostate cancer samples, 23 breast cancer samples imply that miR-141 and miR-21 are up-regulated in the prostate cancer samples and the breast cancer samples, respectively, and as reference miR-16 shows no difference in health and patient samples. +other 30428976 hsa-mir-21 Breast Neoplasms The results of 29 health samples, 18 prostate cancer samples, 23 breast cancer samples imply that miR-141 and miR-21 are up-regulated in the prostate cancer samples and the breast cancer samples, respectively, and as reference miR-16 shows no difference in health and patient samples. +other 30428976 hsa-mir-141 Breast Neoplasms The results of 29 health samples, 18 prostate cancer samples, 23 breast cancer samples imply that miR-141 and miR-21 are up-regulated in the prostate cancer samples and the breast cancer samples, respectively, and as reference miR-16 shows no difference in health and patient samples. +other 30428976 hsa-mir-16 Prostatic Neoplasms The results of 29 health samples, 18 prostate cancer samples, 23 breast cancer samples imply that miR-141 and miR-21 are up-regulated in the prostate cancer samples and the breast cancer samples, respectively, and as reference miR-16 shows no difference in health and patient samples. +other 30427927 hsa-mir-1 Muscular Atrophy Our results suggest Botulinum toxin A-induced denervation of muscle shares molecular characteristics with surgical denervation and other types of neuromuscular dysfunction, and implicates miR-133/Tgf-beta1/Ctfg and miR-1/Hdac4/Myog signaling during the resultant muscle atrophy. +other 30427927 hsa-mir-133 Muscular Atrophy Our results suggest Botulinum toxin A-induced denervation of muscle shares molecular characteristics with surgical denervation and other types of neuromuscular dysfunction, and implicates miR-133/Tgf-beta1/Ctfg and miR-1/Hdac4/Myog signaling during the resultant muscle atrophy. +other 30426778 hsa-mir-613 Status Asthmaticus MiR-133a-3p-EFHD2/CNN2-AC144831.1 interactions and miR3p-CD44/BCL11B-LINC00158/CTA-217C2.1/AC01 interactions were speculated to involve with the development of severe asthma. +lncRNA target 30426564 hsa-mir-10a Esophageal Squamous Cell Carcinoma Taken together the results, they indicated that miR-10a might function as a novel tumor suppressor in vitro and in vivo via targeting Tiam1, suggesting miR-10a to be a candidate biomarker for the ESCC therapy. +genetics_knock down_promote 30426562 hsa-mir-141 Diabetes Mellitus miR-141 also upregulated the expressions of NGFRAP1 in DMED, and knockdown of NGFRAP1 inhibited the productions of NGF and p75NTR. +other 30426560 hsa-mir-210 Urinary Bladder Neoplasms 3p), and finally played a role in the development of NMIBC cancer. +other 30426560 hsa-let-7f-2 Urinary Bladder Neoplasms 3p), and finally played a role in the development of NMIBC cancer. +other 30426560 hsa-mir-92a-2 Urinary Bladder Neoplasms 3p), and finally played a role in the development of NMIBC cancer. +other 30426560 hsa-mir-191 Urinary Bladder Neoplasms 3p), and finally played a role in the development of NMIBC cancer. +other 30426560 hsa-mir-125a Urinary Bladder Neoplasms 3p), and finally played a role in the development of NMIBC cancer. +other 30426547 hsa-mir-34a Stomach Neoplasms The present study investigated the effects of MKL1/miR34a/FOXP3 axis on cell proliferation in MGC803 gastric cancer cells. +genetics_overexpression_suppress 30426539 hsa-mir-383 Carcinoma, Non-Small-Cell Lung Moreover, Wnt1 was the target gene of miR-383, and its overexpression weakened the regulatory effect of miR-383 on cell viability and apoptosis in NSCLC cells. +lncRNA target 30426533 hsa-mir-34c Urinary Bladder Neoplasms Mechanism investigations revealed that NOTCH1 is a target of miR-34c-5p in BCa. All findings in this study revealed that NOTCH1 suppresses the BCa progression by cooperating with lncRNA HCG18 and miR-34c-5p. +other 30426475 hsa-mir-133a Lung Neoplasms A cell-type specific expression pattern and topography of several miRNAs such as mir-145 in fibroblasts, mir-126 in endothelial cells, mir-133a in skeletal muscle cells was observed in normal and lung cancer tissues. +other 30426475 hsa-mir-126 Lung Neoplasms A cell-type specific expression pattern and topography of several miRNAs such as mir-145 in fibroblasts, mir-126 in endothelial cells, mir-133a in skeletal muscle cells was observed in normal and lung cancer tissues. +other 30426475 hsa-mir-145 Lung Neoplasms A cell-type specific expression pattern and topography of several miRNAs such as mir-145 in fibroblasts, mir-126 in endothelial cells, mir-133a in skeletal muscle cells was observed in normal and lung cancer tissues. +transcription factor target 30426460 hsa-mir-199a Myocardial Ischemia The protective effects of downregulated miR-199a-5p on ischemic and hypoxic cardiomyocytes were well recognized, but the underlying mechanism of inhibited miR-199a-5p is not yet clear. +other 30426460 hsa-mir-199a Heart Diseases This study firstly found the correlation between elevated interleukin (IL)-6 and IL-11, as well as subsequent STAT3 signaling activation and the downregulation of miR-199a-5p in hypoxic myocardial samples from children with congenital heart disease. +transcription factor target 30426336 hsa-mir-20a Spinal Cord Diseases Thus, targeting the miR-20a/PDZ-RhoGEF /RhoA/GAP43 axis served as a novel strategy in promoting the sensory function recovery post-SCI. +other 30425571 hsa-mir-617 Breast Neoplasms 3p were commonly upregulated, whereas miR-520b was downregulated in two chemoresistant breast cancer cells compared with chemosensitive cell. +other 30425571 hsa-mir-136 Breast Neoplasms 3p could reduce chemosensitivity of breast cancer, whereas miR-520b could reverse chemoresistance. +other 30425571 hsa-mir-520b Breast Neoplasms 3p could reduce chemosensitivity of breast cancer, whereas miR-520b could reverse chemoresistance. +transcription factor target 30425570 hsa-mir-216a Small Cell Lung Carcinoma CONCLUSION: Taken together, these findings suggest that miR-216a-5p regulates SCLC biology via Bcl-2 family proteins. +lncRNA target 30425531 hsa-mir-593 Stomach Neoplasms 5p may function as a tumor suppressor in GC through a mechanism that regulates JUN pathway via indirectly targeting the MST4 gene. +epigenetics 30425513 hsa-mir-503 Carcinoma, Endometrioid We also found preliminary evidence that regulation of the miR-503 cluster is governed by methylation of the promoter in EEA. +lncRNA target 30425512 hsa-mir-204 Thyroid Cancer, Papillary We also found that UCA1 could regulate expression of IGFBP5, a direct target of miR-204 in PTC. CONCLUSION: Our study demonstrated that UCA1 exerts activity of oncogenes in PTC through regulating miR-204/IGFBP5 axis. +genetics_overexpression_suppress 30425495 hsa-mir-451 Reperfusion Injury The results suggested that CELF2 was a target of miR-451, and that CELF2 overexpression alleviated the inhibitory effect of miR-451 on apoptosis and oxidative stress of the OGD/R cells. +transcription factor target 30425258 hsa-mir-182 Neuralgia As crucial regulators of gene expression, many miRNAs have already gained importance in neuropathic pain, including miR-182, which is predicted to regulate the SCN9A gene. Collectively, we concluded that miR-182 can alleviate SNI- induced neuropathic pain through regulating Nav1.7 in rats. +other 30425242 hsa-mir-26a high grade glioma These findings provide a new link in the mechanistic understanding of TMZ resistance under glioma hypoxia microenvironment, and consequently HIF-1alpha/miR-26a/Bax/Bad signaling pathway as a promising adjuvant therapy for GBM with TMZ. +lncRNA target 30425242 hsa-mir-26a Glioblastoma Further, we demonstrated that HIF-1alpha/miR-26a axis strengthened the acquisition of TMZ resistance through prevention of Bax and Bad in mitochondria dysfunction in GBM. +circulation_biomarker_diagnosis_up 30425199 hsa-mir-19b Angina Pectoris Our previous study found that microRNA (miR)-19b encapsulated within endothelial MPs (EMPs) may contribute to the upregulation of circulating miR-19b in unstable angina patients. +other 30425059 hsa-mir-146a Melanoma In summary, these data show that miR-146a plays a central role within the STAT1/IFNgamma axis in the melanoma microenvironment, affecting melanoma migration, proliferation, and mitochondrial fitness as well as PD-L1 levels. +genetics_knock down_suppress 30424877 hsa-mir-203 Leukemia, Myeloid, Acute Moreover, rescue experiments demonstrated that miR-203 inhibitor could reverse the role of hsa_circ_100290 knockdown on proliferation and apoptosis in AML cells. Overall, the present study identifies the crucial regulation of hsa_circ_100290 in AML cell proliferation and apoptosis via targeting the miR-203/Rab10 axis. +circulation_biomarker_diagnosis_ns 30424721 hsa-mir-203a Carcinoma, Hepatocellular 5p and miR-203a-3p, which are reported or predicted to target TFF3, also hold promise as blood-based biomarkers for HCC. +lncRNA target 30423928 hsa-mir-338 Breast Neoplasms 3p inhibitor sequence rescued the expression of genes and the proliferative effects induced by E2 through GPER in SkBr3 cancer cells and CAFs. +lncRNA target 30423818 hsa-mir-15b Glioma "In this study, we found that microRNA-103 (miR-103), microRNA-195 (miR-195), or microRNA-15b (miR-15b), which all have the same 5' ""seed"" miRNA portion and share common binding sites in the SALL4 3'-untranslated region (UTR), were downregulated in glioma tissues and cell lines. In conclusion, these data suggest that miR-103, miR-195, and miR-15b post-transcriptionally downregulated the expression of SALL4 and suppressed glioma cell growth, migration, and invasion, and increased cell apoptosis." +genetics_overexpression_promote 30423576 hsa-mir-423 Osteosarcoma Overexpression of miR +other 30423553 hsa-mir-136 Carcinoma, Non-Small-Cell Lung CONCLUSION: CRNDE acted as a tumor oncogene by exhibiting oncogenic properties of human HCC and revealed a novel CRNDE-miR5P-IRX5 regulatory network in HCC. +other 30423553 hsa-mir-136 Carcinoma, Hepatocellular CONCLUSION: CRNDE acted as a tumor oncogene by exhibiting oncogenic properties of human HCC and revealed a novel CRNDE-miR5P-IRX5 regulatory network in HCC. +transcription factor target 30423456 hsa-mir-122 Rhabdoviridae The results demonstrated that miR-214 inhibited the replication of SCRV, while miR-122 promoted the replication of SCRV and there was no correlation between the miR-135a and SCRV replication. +transcription factor target 30423456 hsa-mir-135a Rhabdoviridae The results demonstrated that miR-214 inhibited the replication of SCRV, while miR-122 promoted the replication of SCRV and there was no correlation between the miR-135a and SCRV replication. +transcription factor target 30423456 hsa-mir-214 Rhabdoviridae The results demonstrated that miR-214 inhibited the replication of SCRV, while miR-122 promoted the replication of SCRV and there was no correlation between the miR-135a and SCRV replication. +other 30423386 hsa-mir-10b Neoplasms, Second Primary These results indicate that miR-10b-5p may have a therapeutic significance for obesity and obesity-related cancers. +genetics_GWAS 30422934 hsa-mir-32c Primary Ovarian Insufficiency OBJECTIVE: The purpose of this study was to investigate the association of microRNA polymorphisms (miR-25T>C, miR-32C>A, miR-125C>T, and miR-222G>T) with primary ovarian insufficiency (POI) in Korean women. CONCLUSIONS: After considering multiple comparisons, we concluded that miR-25T>C, miR-32C>A, miR-125C>T, and miR-222G>T had no relation with POI. +genetics_GWAS 30422934 hsa-mir-125c Primary Ovarian Insufficiency OBJECTIVE: The purpose of this study was to investigate the association of microRNA polymorphisms (miR-25T>C, miR-32C>A, miR-125C>T, and miR-222G>T) with primary ovarian insufficiency (POI) in Korean women. CONCLUSIONS: After considering multiple comparisons, we concluded that miR-25T>C, miR-32C>A, miR-125C>T, and miR-222G>T had no relation with POI. +circulation_biomarker_diagnosis_ns 30422797 hsa-mir-1908 Ovarian Neoplasms platinum-resistant (n=15) ovarian cancer patients, resulting in a panel of mature EV-associated miRNAs (including ovarian cancer associated miR-181a, miR-1908, miR-21, miR-486 and miR-223), which were differentially abundant in the plasma of platinum-resistant patients. +circulation_biomarker_diagnosis_ns 30422797 hsa-mir-21 Ovarian Neoplasms platinum-resistant (n=15) ovarian cancer patients, resulting in a panel of mature EV-associated miRNAs (including ovarian cancer associated miR-181a, miR-1908, miR-21, miR-486 and miR-223), which were differentially abundant in the plasma of platinum-resistant patients. +circulation_biomarker_diagnosis_ns 30422797 hsa-mir-486 Ovarian Neoplasms platinum-resistant (n=15) ovarian cancer patients, resulting in a panel of mature EV-associated miRNAs (including ovarian cancer associated miR-181a, miR-1908, miR-21, miR-486 and miR-223), which were differentially abundant in the plasma of platinum-resistant patients. +circulation_biomarker_diagnosis_ns 30422797 hsa-mir-181a Ovarian Neoplasms platinum-resistant (n=15) ovarian cancer patients, resulting in a panel of mature EV-associated miRNAs (including ovarian cancer associated miR-181a, miR-1908, miR-21, miR-486 and miR-223), which were differentially abundant in the plasma of platinum-resistant patients. +circulation_biomarker_diagnosis_ns 30422797 hsa-mir-223 Ovarian Neoplasms platinum-resistant (n=15) ovarian cancer patients, resulting in a panel of mature EV-associated miRNAs (including ovarian cancer associated miR-181a, miR-1908, miR-21, miR-486 and miR-223), which were differentially abundant in the plasma of platinum-resistant patients. +circulation_biomarker_diagnosis_up 30421783 hsa-mir-146a Delayed Graft Function CONCLUSION We conclude that miR-146a-5p expression has a distinct pattern in the renal tissue and perhaps in the peripheral blood in the setting of DGF. +other 30420952 hsa-mir-200c Polycystic Ovary Syndrome PCOS patients had an increased risk of pregnancy complications in low-expression groups of both miR-141 and miR-200c. +other 30420952 hsa-mir-141 Polycystic Ovary Syndrome PCOS patients had an increased risk of pregnancy complications in low-expression groups of both miR-141 and miR-200c. +circulation_biomarker_diagnosis_up 30420640 hsa-mir-128 Lung Neoplasms 3p in whole blood can serve as novel biomarkers for the early detection of lung cancer. +circulation_biomarker_prognosis_ns 30420592 hsa-mir-21 Esophageal Neoplasms Among them, the expression levels of miR-133a, miR-133b, miR-138, miR-203, and miR-655 in tissue and the expression level of miR-21 in blood are potential prognostic candidates for predicting OS in EC. +other 30420300 hsa-mir-141 Fetal Macrosomia 3p could stimulate placental cell proliferation to participate in the occurrence and development of NDFMS. +genetics_overexpression_suppress 30420101 hsa-mir-218 hereditary diffuse gastric cancer MATERIALS AND METHODS: We used miR-218 mimic to transfect gastric cancer cell lines AGS and SGC-7901, and the overexpression efficiency was validated using qRT-PCR assay. +circulation_biomarker_diagnosis_ns 30419948 hsa-mir-149 Urinary Bladder Neoplasms Mechanistically, we found that DANCR was distributed mostly in the cytoplasm and DANCR functioned as a miRNA sponge to positively regulate the expression of musashi RNA binding protein 2 (MSI2) through sponging miR-149 and subsequently promoted malignant phenotypes of bladder cancer cells, thus playing an oncogenic role in bladder cancer pathogenesis. +genetics_GWAS 30419846 hsa-mir-10a Myeloproliferative Disorders Moreover, miR-10a and HOXB4 overexpression seemed associated with DNMT3A mutation in hematological malignancies. +transcription factor target 30419349 hsa-mir-26b Triple Negative Breast Neoplasms Moreover, miR-26b, acting as a tumor suppressor in TNBC, directly repressed the expression of DEPDC1 and mitigated its promotive effects on cell growth and colony formation. These results indicate that DEPDC1, negatively regulated by miR-26b, promotes cell proliferation and tumor growth via up-regulating FOXM1 expression, implying an important underlying mechanism of regulating the progression of TNBC. +exosome 30419348 hsa-mir-145 Carcinoma, Pancreatic Ductal Here, we used exosomes from human umbilical cord mesenchymal stromal cells (hucMSCs) to deliver exogenous miR5p, which inhibited PDAC cell proliferation and invasion and increased apoptosis and cell cycle arrest, concomitant with decreased Smad3 expression in vitro. +circulation_biomarker_diagnosis_up 30419346 hsa-mir-548g Stomach Neoplasms Then, we investigated whether circFAT1(e2) acts as a sponge of microRNA-549g(miR-548g) and regulates the expression of tumor suppressor RUNX1 in GC cells. In conclusion, circFAT1(e2) may play a role as a tumor suppressor in GC cells by regulating the miR-548g/RUNX1 axis in the cytoplasm and targeting YBX1 in the nucleus. +other 30419280 hsa-mir-1 Hypoxia miR-1 levels are elevated after hypoxia; AngII treatment reverses the up-regulation of miR-1, while ERK-siRNA abolishes that effect of AngII. +other 30419147 hsa-mir-98 Myocardial Reperfusion Injury In addition, over-expression of miR-98 could significantly reduce the myocardial oxidative stress and ischemic injury as well as cell apoptosis. +lncRNA target 30418194 hsa-mir-27b Carcinoma, Hepatocellular MiR-27b suppresses the expression of GP73 and is therefore a potential prognostic biomarker and therapy target in HCC. +lncRNA target 30418172 hsa-mir-668 Acute Kidney Injury Together, these results identify a HIF-1alpha/miR-668/MTP18 axis that may have potential as a therapeutic target for AKI. +lncRNA target 30417784 hsa-mir-125b Breast Neoplasms METHODS: We investigated the effect of vincristine, vinblastine, and vinorelbine on the expression of oncogenic and tumor-suppressive miRNAs (miR-15a-5p, miR +lncRNA target 30417784 hsa-mir-16 Breast Neoplasms METHODS: We investigated the effect of vincristine, vinblastine, and vinorelbine on the expression of oncogenic and tumor-suppressive miRNAs (miR-15a-5p, miR +lncRNA target 30417784 hsa-mir-21 Breast Neoplasms METHODS: We investigated the effect of vincristine, vinblastine, and vinorelbine on the expression of oncogenic and tumor-suppressive miRNAs (miR-15a-5p, miR +lncRNA target 30417784 hsa-mir-421 Breast Neoplasms METHODS: We investigated the effect of vincristine, vinblastine, and vinorelbine on the expression of oncogenic and tumor-suppressive miRNAs (miR-15a-5p, miR +lncRNA target 30417784 hsa-mir-221 Breast Neoplasms METHODS: We investigated the effect of vincristine, vinblastine, and vinorelbine on the expression of oncogenic and tumor-suppressive miRNAs (miR-15a-5p, miR +lncRNA target 30417784 hsa-mir-222 Breast Neoplasms METHODS: We investigated the effect of vincristine, vinblastine, and vinorelbine on the expression of oncogenic and tumor-suppressive miRNAs (miR-15a-5p, miR +lncRNA target 30417784 hsa-mir-214 Breast Neoplasms METHODS: We investigated the effect of vincristine, vinblastine, and vinorelbine on the expression of oncogenic and tumor-suppressive miRNAs (miR-15a-5p, miR +lncRNA target 30417784 hsa-mir-148a Breast Neoplasms METHODS: We investigated the effect of vincristine, vinblastine, and vinorelbine on the expression of oncogenic and tumor-suppressive miRNAs (miR-15a-5p, miR +lncRNA target 30417784 hsa-mir-25 Breast Neoplasms METHODS: We investigated the effect of vincristine, vinblastine, and vinorelbine on the expression of oncogenic and tumor-suppressive miRNAs (miR-15a-5p, miR +lncRNA target 30417784 hsa-mir-29b Breast Neoplasms METHODS: We investigated the effect of vincristine, vinblastine, and vinorelbine on the expression of oncogenic and tumor-suppressive miRNAs (miR-15a-5p, miR +other 30417652 hsa-mir-1260b Breast Neoplasms Additionally, hsa_circ_0087378 was validated to be downregulated in ER-positive BC and the hsa_circ_0087378-miR-1260b-SFRP1 axis was proposed to be a key regulatory pathway. +lncRNA target 30417526 hsa-mir-186 Stomach Neoplasms 5p inhibited cell cycle and promoted apoptosis by targeting NEK2. +transcription factor target 30417525 hsa-mir-217 Liver Injury This study aims to explore the effects of miR-217 targeting NAT2 on hepatocyte proliferation, apoptosis, and autophagy following carbon tetrachloride (CCL4)-induced liver injury. Collectively, miR-217 targeting NAT2 inhibits proliferation and promotes apoptosis and autophagy of hepatocytes in CCL4-induced liver injury. +transcription factor target 30417502 hsa-mir-129 Stomach Neoplasms The miR-129 pairs (miR5p and -3p) play pivotal roles in GC to suppress its proliferation and migration in vitro and slow down GC growth in vivo by repressing WWP1. +lncRNA target 30417418 hsa-mir-1252 Carcinoma, Non-Small-Cell Lung Downregulation of circABCB10 suppressed NSCLC cell proliferation and migration by promoting microRNA miR-1252 expression and suppressing Forkhead box 2 (FOXR2). These data suggested that circABCB10 acted as a tumor promoter through a novel miR-1252/FOXR2 axis, providing potential biomarkers and therapeutic targets for the management of NSCLC. +other 30417353 hsa-mir-181b Aortic Aneurysm, Abdominal We found LA administration dose-dependently reduced the incidence of AngII-induced AAA, aneurysm diameter enlargement, elastin degradation, matrix metalloproteinase production, pro-inflammatory cytokines and miR-181b expression, and vascular smooth muscle cell apoptosis. Collectively, LA could attenuate AngII-induced AAA by modulating the miR-181b/SIRT1/HO-1 signaling. +transcription factor target 30417352 hsa-mir-146a Myocardial Reperfusion Injury In vivo experiments suggested that troxerutin alleviated myocardial I/R injury in rats via inhibition of miR-146a-5p. +lncRNA target 30416861 hsa-mir-621 Carcinoma, Hepatocellular Taken together, our findings suggest that miR-621 acts as a tumor suppressor gene in HCC progression by downregulating CAPRIN1 expression and could be a novel potential diagnostic and prognostic biomarker for HCC. +transcription factor target 30416858 hsa-mir-17 Prostatic Neoplasms The dual effect is consistent with the contradictory findings on the role of miR-17 in prostate cancer progression, whereby it controls important oncogenic and tumor-suppressive genes. +genetics_overexpression_promote 30416798 hsa-mir-374b Carcinoma, Non-Small-Cell Lung Furthermore, overexpression of miRNA-374b markedly reduced the viability of NSCLC cells, but miRNA-374b inhibitor increased the viability of NSCLC cells compared with that in negative controls. +other 30416683 hsa-mir-210 Ichthyosis, Lamellar RESULTS: Subjects with HI presented higher levels of miR-21, miR-23b, miR-145 and miR-210 compared to the other groups, while higher levels of miR-26 was observed in the HC group. +other 30416683 hsa-mir-210 Coproporphyria, Hereditary RESULTS: Subjects with HI presented higher levels of miR-21, miR-23b, miR-145 and miR-210 compared to the other groups, while higher levels of miR-26 was observed in the HC group. +other 30416683 hsa-mir-26 Coproporphyria, Hereditary RESULTS: Subjects with HI presented higher levels of miR-21, miR-23b, miR-145 and miR-210 compared to the other groups, while higher levels of miR-26 was observed in the HC group. +other 30416683 hsa-mir-23b Ichthyosis, Lamellar RESULTS: Subjects with HI presented higher levels of miR-21, miR-23b, miR-145 and miR-210 compared to the other groups, while higher levels of miR-26 was observed in the HC group. +other 30416683 hsa-mir-21 Ichthyosis, Lamellar RESULTS: Subjects with HI presented higher levels of miR-21, miR-23b, miR-145 and miR-210 compared to the other groups, while higher levels of miR-26 was observed in the HC group. +other 30416683 hsa-mir-145 Coproporphyria, Hereditary RESULTS: Subjects with HI presented higher levels of miR-21, miR-23b, miR-145 and miR-210 compared to the other groups, while higher levels of miR-26 was observed in the HC group. +other 30416683 hsa-mir-23b Coproporphyria, Hereditary RESULTS: Subjects with HI presented higher levels of miR-21, miR-23b, miR-145 and miR-210 compared to the other groups, while higher levels of miR-26 was observed in the HC group. +other 30416683 hsa-mir-21 Coproporphyria, Hereditary RESULTS: Subjects with HI presented higher levels of miR-21, miR-23b, miR-145 and miR-210 compared to the other groups, while higher levels of miR-26 was observed in the HC group. +other 30416683 hsa-mir-26 Ichthyosis, Lamellar RESULTS: Subjects with HI presented higher levels of miR-21, miR-23b, miR-145 and miR-210 compared to the other groups, while higher levels of miR-26 was observed in the HC group. +other 30416683 hsa-mir-145 Ichthyosis, Lamellar RESULTS: Subjects with HI presented higher levels of miR-21, miR-23b, miR-145 and miR-210 compared to the other groups, while higher levels of miR-26 was observed in the HC group. +epigenetics 30416662 hsa-mir-214 Stomach Neoplasms 3P/TET2 axis plays a critical role in GC progress via methylation of RASSF1A. +lncRNA target 30416655 hsa-mir-196b Breast Neoplasms Our data collectively indicate that miR-196b-5p inhibits cell growth and metastasis in breast cancer through down-regulating COL1A1, supporting the targeting of the new miR-196b-5p/COL1A1 axis as a promising effective therapeutic approach for breast cancer. +circulation_biomarker_diagnosis_ns 30416509 hsa-mir-155 Coronary Artery Disease CONCLUSIONS: The level of miRNA-155 in peripheral blood CD4(+) T lymphocytes and the level of IFN-gamma are closely correlated with the severity of CAD. +other 30416452 hsa-mir-133 Cardiomegaly This has been done by using alpha-MSH and selective MC5R agonists and assessing the expression of GLUT4 and GLUT1 transporters, miR-133 and urotensin receptor levels as a marker of cardiac hypertrophy. +other 30416452 hsa-mir-133 Hypertrophy This has been done by using alpha-MSH and selective MC5R agonists and assessing the expression of GLUT4 and GLUT1 transporters, miR-133 and urotensin receptor levels as a marker of cardiac hypertrophy. +lncRNA target 30416388 hsa-mir-7 Arthritis, Rheumatoid In addition, we subjected microRNAs from foot and ankle RA patients to a microRNA-specific microarray and found that miR5p targeted the 3'-UTR of p65, negatively regulating its expression. +other 30416360 hsa-mir-15b Adenocarcinoma of Lung Two of the 10 most upregulated miRNAs (hsa-mir-20a-5p and hsa-mir-15b-5p) were associated with lung cancer. +other 30416360 hsa-mir-20a Adenocarcinoma of Lung Two of the 10 most upregulated miRNAs (hsa-mir-20a-5p and hsa-mir-15b-5p) were associated with lung cancer. +other 30416314 hsa-mir-21 Pancreatic Carcinoma CONCLUSION: Different immune phenotypic CAF subpopulations can be identified in PC, using markers such as cytoglobin, CD271, and miR-21. +other 30415442 hsa-let-7d Stomach Neoplasms The aim of this study was to evaluate the effect of a chimera consisted of nucleolin specific aptamer (NCL-Apt) and miRNA let-7d on JAK2 expression level and activity in gastric cancer cells. +lncRNA target 30415263 hsa-mir-520c Carcinoma, Hepatocellular CONCLUSION: In summary, our results suggested that the HOXA-AS2/miR-520c-3p/GPC3 axis may play an important role in the regulation of PTC progression, which could serve as a biomarker and therapeutic target for HCC. +transcription factor target 30415251 hsa-mir-23a Cardiomyopathies miR-323a-3p may be a new marker for cardiac fibrosis progression and that inhibition of miR-323a-3p may be a promising therapeutic target for the treatment of cardiac fibrosis. +genetics_overexpression_promote 30415006 hsa-mir-93 Colorectal Neoplasms Overexpression of long non coding RNA CA3-AS1 suppresses proliferation, invasion and promotes apoptosis via miRNA-93/PTEN axis in colorectal cancer. In summary, our study demonstrated that CA3-AS1/miR-93/PTEN axis may play an important role in the regulation of colorectal cancer progression, which provides new insights for clinical treatment. +genetics_knock down_promote 30415005 hsa-mir-423 Prostatic Neoplasms 5p knockdown inhibited the proliferation and promoted the apoptosis of PC3 cells through GRIM-19. +genetics_overexpression_promote 30414952 hsa-mir-155 Corneal dystrophy, epithelial basement membrane The subsequent overexpression of miR-155 significantly blocked the stress-induced impairment of GC response, due to changes in FBXO11 and BCL6 expression, as well as increased apoptosis in B cells both in vivo and in vitro. +other 30414611 hsa-mir-7-2 Thyroid Cancer, Papillary 2, and miR-146b are potential biomarkers for PTC staging and FN1, CLDN1, and TNFRSF12A may serve as markers of prognosis in PTC. +other 30414611 hsa-mir-204 Thyroid Cancer, Papillary 2, and miR-146b are potential biomarkers for PTC staging and FN1, CLDN1, and TNFRSF12A may serve as markers of prognosis in PTC. +other 30414611 hsa-mir-146b Thyroid Cancer, Papillary 2, and miR-146b are potential biomarkers for PTC staging and FN1, CLDN1, and TNFRSF12A may serve as markers of prognosis in PTC. +other 30414568 hsa-mir-3 Diabetic Nephropathies 55p levels negatively correlated with albuminuria. +other 30414538 hsa-mir-9 Carcinoma, Merkel Cell This is underlined by the expression of the REST-regulated microRNAs miR-9/9* in REST-negative MCC cell lines. +other 30414370 hsa-mir-146a Lupus Erythematosus, Systemic miR-146a and miR-155 showed correlation with the diagnosis (rs=0.363 and 0.330, respectively) and the age of the patients (rs =0.239 and 0.366, respectively), and miR-155 showed correlation with the presence of secondary Raynaud syndrome (Spearman correlation coefficient=0.250) Conclusions: Our data showed that the expression levels of miR-146a and miR-155 in PB could be used as diagnostic biomarkers for SLE patients but larger study is needed to confirm these results. +genetics_overexpression_promote 30414370 hsa-mir-155 Lupus Erythematosus, Systemic Results: Whole peripheral blood expression levels of miR-146a and miR-155 were overexpressed in 62.5% and 50%, respectively, of the SLE patients compared to HCs. +lncRNA target 30414341 hsa-mir-217 Glomerulonephritis, Membranous Down-regulation of XIST ameliorates podocyte apoptosis via the miRTLR4 pathway, which may improve membranous nephropathy. +other 30413725 hsa-mir-19b Pulmonary Fibrosis Collectively, these findings indicated that upregulation of the miR-19a-19b-20a sub-cluster expression in lung fibroblasts counteracted TGF-beta-associated pathogenic activation of fibroblasts in murine pulmonary fibrosis. +other 30413725 hsa-mir-20 Pulmonary Fibrosis Collectively, these findings indicated that upregulation of the miR-19a-19b-20a sub-cluster expression in lung fibroblasts counteracted TGF-beta-associated pathogenic activation of fibroblasts in murine pulmonary fibrosis. +other 30413725 hsa-mir-20a Pulmonary Fibrosis Collectively, these findings indicated that upregulation of the miR-19a-19b-20a sub-cluster expression in lung fibroblasts counteracted TGF-beta-associated pathogenic activation of fibroblasts in murine pulmonary fibrosis. +other 30413725 hsa-mir-19a Pulmonary Fibrosis Collectively, these findings indicated that upregulation of the miR-19a-19b-20a sub-cluster expression in lung fibroblasts counteracted TGF-beta-associated pathogenic activation of fibroblasts in murine pulmonary fibrosis. +lncRNA target 30413718 hsa-mir-21 Breast Neoplasms Inhibiting WIP1 and miR-21 selectively inhibits the proliferation, survival and tumorigenic potential of the HER2+ breast cancer cells harboring 17q23 amplification. +circulation_biomarker_prognosis_up 30413650 hsa-mir-454 Glioma 3p in glioma have not been systematically investigated, especially regarding the relationship between circulating and tissue miR +lncRNA target 30413613 hsa-mir-182 Osteoporosis 5p promotes the proliferation and differentiation of osteoblasts in OP rats through Rap1/MAPK signaling pathway activation by up-regulating ADCY6, which may represent a novel target for OP treatment. +lncRNA target 30412893 hsa-let-7 Skin Diseases Our data imply the dysregulation of letmediated molecular machinery for developmental timing control by GO-PEG in nematodes with deficit in epidermal barrier caused by bli-1(RNAi). +lncRNA target 30412748 hsa-mir-145 Carcinoma, Hepatocellular CONCLUSION: Our resultssuggest that CASE inhibits HCC progression via mediating the interaction of miR-145/miR-21 and Smad3 phosphorylation, especially miR-145/miR-21 mediated Smad3 phosphorylation, which maybe provides an important theoretical foundation for CASE's anti-HCC therapy used for patients in a near future. +lncRNA target 30412748 hsa-mir-21 Carcinoma, Hepatocellular CONCLUSION: Our resultssuggest that CASE inhibits HCC progression via mediating the interaction of miR-145/miR-21 and Smad3 phosphorylation, especially miR-145/miR-21 mediated Smad3 phosphorylation, which maybe provides an important theoretical foundation for CASE's anti-HCC therapy used for patients in a near future. +genetics_overexpression_suppress 30412746 hsa-mir-3926 Arthritis, Rheumatoid Overexpression of miR-3926 led to a reduction of endogenous TLR5 in RASFs, whereas down-regulation of miR-3926 increased TLR5 expression. +lncRNA target 30412716 hsa-mir-125b Urinary Bladder Neoplasms Furthermore, this study also identified miR-125b as a downstream target of HOXA-AS2 and revealed the downregulation of miR-125b by HOXA-AS2 as well as the involvement of HOXA-AS2/miR-125b/Smad2 interactions in the functional role of HOXA-AS2 in mediating the migration, invasion and stemness of bladder cancer cells. +other 30412705 hsa-mir-144 Anemia, Sickle Cell The genome-wide miRNA microarray and primary erythroid progenitor data support a miR-144/NRF2-mediated mechanism of gamma-globin gene regulation in SCD. +transcription factor target 30412601 hsa-mir-21 Neoplasms, Hormone-Dependent Integrated miRNA and mRNA analysis in IGFIR-driven tumors identified interaction pairs with roles in ErbB signaling while cross-species analysis revealed coordinated expression of a subset of conserved miRNAs and their targets including miR5p (Reck, Timp3 and Tgfbr3). +other 30411548 hsa-mir-27a Obesity OBJECTIVES: The aim of the study was to investigate how adipocyte miR-27a and miR-143 expression may be influenced by CLA in obese rats. RESULTS: After 12 weeks, the obese rats in the HFD group, compared with rats in the NFD group, demonstrated a significant decrease in the expression of miR-27a (p < 0.05) and a significant increase in the expression of miR-143 (p < 0.05). +other 30411548 hsa-mir-143 Obesity OBJECTIVES: The aim of the study was to investigate how adipocyte miR-27a and miR-143 expression may be influenced by CLA in obese rats. RESULTS: After 12 weeks, the obese rats in the HFD group, compared with rats in the NFD group, demonstrated a significant decrease in the expression of miR-27a (p < 0.05) and a significant increase in the expression of miR-143 (p < 0.05). +other 30411298 hsa-mir-17 Liver Cirrhosis 5p, miR-18a, miR-195 and miR-210 was decreased in FNH as compared with cirrhosis and/or HCC. +other 30411298 hsa-mir-18a Liver Cirrhosis The decreased levels of miR-18a, miR-195 and miR-210 may further differentiate FNH from cirrhosis, reflecting the different pathogenesis of these two entities contrary to some histologically similar features. +other 30411298 hsa-mir-18a Carcinoma, Hepatocellular The decreased levels of miR-18a, miR-195 and miR-210 may further differentiate FNH from cirrhosis, reflecting the different pathogenesis of these two entities contrary to some histologically similar features. +other 30411298 hsa-mir-210 Liver Cirrhosis The decreased levels of miR-18a, miR-195 and miR-210 may further differentiate FNH from cirrhosis, reflecting the different pathogenesis of these two entities contrary to some histologically similar features. +other 30411298 hsa-mir-17 Carcinoma, Hepatocellular 5p, miR-18a, miR-195 and miR-210 was decreased in FNH as compared with cirrhosis and/or HCC. +other 30411298 hsa-mir-210 Carcinoma, Hepatocellular The decreased levels of miR-18a, miR-195 and miR-210 may further differentiate FNH from cirrhosis, reflecting the different pathogenesis of these two entities contrary to some histologically similar features. +lncRNA target 30411211 hsa-mir-92a Encephalomyelitis, Autoimmune, Experimental Enhanced miR-92a expression was accompanied by reduced expression TSC1 or DUSP10, predicted miR-92a targets, in EAE spinal cords. +other 30411131 hsa-mir-146a Chronic Periodontitis CONCLUSIONS: The expression of miR-146a in saliva of chronic periodontitis patients is abnormally high, and the specific expression is consistent with the degree of gingival inflammation and periodontal injury. +other 30411131 hsa-mir-146a Gingivitis CONCLUSIONS: The expression of miR-146a in saliva of chronic periodontitis patients is abnormally high, and the specific expression is consistent with the degree of gingival inflammation and periodontal injury. +genetics_overexpression_suppress 30411121 hsa-mir-199b Head and Neck Neoplasms Overexpression of miR-199b-5p inhibited HNSCC cell proliferation and invasion. +genetics_knock down_suppress 30410864 hsa-mir-1 Glioma Mechanistically, knockdown of UCA1 decreased Slug expression by acting as a competitive endogenous RNA (ceRNA) through competitive binding with miR-1 and miR-203a; this effect was further evidenced by the fact that transfection with miR-1 or miR-203a inhibitors abrogated the effects of UCA1 knockdown on Slug expression, and UCA1 colocalized with miR-1 and miR-203a in glioma tissues. +genetics_knock down_suppress 30410864 hsa-mir-203a Glioma Mechanistically, knockdown of UCA1 decreased Slug expression by acting as a competitive endogenous RNA (ceRNA) through competitive binding with miR-1 and miR-203a; this effect was further evidenced by the fact that transfection with miR-1 or miR-203a inhibitors abrogated the effects of UCA1 knockdown on Slug expression, and UCA1 colocalized with miR-1 and miR-203a in glioma tissues. +lncRNA target 30410864 hsa-mir-206 Glioma The long non-coding RNA (lncRNA) UCA1 has been shown to promote the proliferation and invasion of cervical cancer cells through regulating miR-206 expression, but the involvement of UCA1 in regulating the stemness and epithelial-mesenchymal transition (EMT) of glioma cells is unknown. +lncRNA target 30410722 hsa-mir-101 Stomach Neoplasms CONCLUSIONS: The study uncovered that PHLDA1 was regulated by circ_0027599/miR-101, which suppressed gastric cancer survival and metastasis in gastric cancer. +circulation_biomarker_diagnosis_ns 30410681 hsa-mir-21 Squamous Cell Carcinoma of Head and Neck Oncogenic miRNAs (such as miR-21, miR-27) were detectable in high quantities in the circulating EVs and plasma of patients with OSCC. +circulation_biomarker_diagnosis_ns 30410681 hsa-mir-27 Squamous Cell Carcinoma of Head and Neck Oncogenic miRNAs (such as miR-21, miR-27) were detectable in high quantities in the circulating EVs and plasma of patients with OSCC. +circulation_biomarker_diagnosis_up 30410665 hsa-mir-494 Lymphoma, B-Cell Quantification of 99 DLBCL tissues, to select miRNA implicated in immunosuppressive monocytes/macrophage biology, found miR-494 differentially elevated. Circulating c-f miR-494 and miR-21 are disease response biomarkers with differential response stratified by interim-PET/CT in patients with DLBCL. +circulation_biomarker_diagnosis_ns 30410665 hsa-mir-21 Lymphoma, B-Cell Circulating c-f miR-494 and miR-21 are disease response biomarkers with differential response stratified by interim-PET/CT in patients with DLBCL. +other 30410604 hsa-mir-602 Carcinoma, Pancreatic Ductal Five miRNAs (mir2-3p, mir-890, mir-3201, mir-602, and mir-877) were identified as potential diagnostic and prognostic biomarkers for PDAC. +other 30410604 hsa-mir-890 Carcinoma, Pancreatic Ductal Five miRNAs (mir2-3p, mir-890, mir-3201, mir-602, and mir-877) were identified as potential diagnostic and prognostic biomarkers for PDAC. +other 30410604 hsa-mir-3201 Carcinoma, Pancreatic Ductal Five miRNAs (mir2-3p, mir-890, mir-3201, mir-602, and mir-877) were identified as potential diagnostic and prognostic biomarkers for PDAC. +other 30410604 hsa-mir-16-2 Carcinoma, Pancreatic Ductal Five miRNAs (mir2-3p, mir-890, mir-3201, mir-602, and mir-877) were identified as potential diagnostic and prognostic biomarkers for PDAC. +other 30410604 hsa-mir-877 Carcinoma, Pancreatic Ductal Five miRNAs (mir2-3p, mir-890, mir-3201, mir-602, and mir-877) were identified as potential diagnostic and prognostic biomarkers for PDAC. +lncRNA target 30410394 hsa-mir-365 Esophageal Squamous Cell Carcinoma The study of biomarkers suggests involvement of phosphoserine aminotransferase 1 (PSAT1) as a favorable target for miR-365, and its abnormal expression inverted the miR +transcription factor target 30410355 hsa-mir-10a Cholangiocarcinoma These results indicate that miR-10a-5p may serve as a potential target for the treatment of CCA and help to develop effective therapeutic strategies. +genetics_GWAS 30409964 hsa-mir-146b Ovarian Neoplasms These findings indicate that miR-146b-FBXL10 axis is an important epigenetic regulation pathway in EOC. +transcription factor target 30409799 hsa-mir-181b Leukemia, Lymphocytic, Chronic, B-Cell The expression signature is composed of miR-21, miR-150, miR-146b and miR-181b, with confirmed targets significantly enriched in pathways involved in cancer, immunity and inflammation. +transcription factor target 30409799 hsa-mir-146b Leukemia, Lymphocytic, Chronic, B-Cell The expression signature is composed of miR-21, miR-150, miR-146b and miR-181b, with confirmed targets significantly enriched in pathways involved in cancer, immunity and inflammation. +exosome 30409700 hsa-mir-16 Multiple Myeloma CONCLUSION: Our findings demonstrate that LINC00461, a sponge for miR-15a/16, is highly expressed in MSC-derived exosomes, and enhances MM cell proliferation, which may become an excellent candidate for therapeutic applications. +exosome 30409700 hsa-mir-15a Multiple Myeloma CONCLUSION: Our findings demonstrate that LINC00461, a sponge for miR-15a/16, is highly expressed in MSC-derived exosomes, and enhances MM cell proliferation, which may become an excellent candidate for therapeutic applications. +genetics_GWAS 30409304 hsa-mir-652 Chronic Periodontitis RESULTS: 3 DE-miRNAs (miR-375, miR-3609 and miR-3652) expressed in both CP and OSCC critically regulated most DEGs. CONCLUSION: Bioinformatic analysis of available datasets implicated 1 directly interacting cross-talk gene (NCAPH), 4 indirectly interacting cross-talk genes (NCAPH, NR2F2, FN1, and MPPED1) and 3 DE-miRNAs (hsa-miR-375, miR-3609 and miR-3652) as shared genetic and epigenetic expression patterns between CP and OSCC. +genetics_GWAS 30409304 hsa-mir-652 Squamous Cell Carcinoma of Head and Neck RESULTS: 3 DE-miRNAs (miR-375, miR-3609 and miR-3652) expressed in both CP and OSCC critically regulated most DEGs. CONCLUSION: Bioinformatic analysis of available datasets implicated 1 directly interacting cross-talk gene (NCAPH), 4 indirectly interacting cross-talk genes (NCAPH, NR2F2, FN1, and MPPED1) and 3 DE-miRNAs (hsa-miR-375, miR-3609 and miR-3652) as shared genetic and epigenetic expression patterns between CP and OSCC. +genetics_GWAS 30409304 hsa-mir-609 Squamous Cell Carcinoma of Head and Neck RESULTS: 3 DE-miRNAs (miR-375, miR-3609 and miR-3652) expressed in both CP and OSCC critically regulated most DEGs. CONCLUSION: Bioinformatic analysis of available datasets implicated 1 directly interacting cross-talk gene (NCAPH), 4 indirectly interacting cross-talk genes (NCAPH, NR2F2, FN1, and MPPED1) and 3 DE-miRNAs (hsa-miR-375, miR-3609 and miR-3652) as shared genetic and epigenetic expression patterns between CP and OSCC. +genetics_GWAS 30409304 hsa-mir-609 Chronic Periodontitis RESULTS: 3 DE-miRNAs (miR-375, miR-3609 and miR-3652) expressed in both CP and OSCC critically regulated most DEGs. CONCLUSION: Bioinformatic analysis of available datasets implicated 1 directly interacting cross-talk gene (NCAPH), 4 indirectly interacting cross-talk genes (NCAPH, NR2F2, FN1, and MPPED1) and 3 DE-miRNAs (hsa-miR-375, miR-3609 and miR-3652) as shared genetic and epigenetic expression patterns between CP and OSCC. +transcription factor target 30408806 hsa-mir-202 Rhinitis, Allergic 5p could target MATN2 to induce M2 polarization involved in allergic rhinitis. +other 30408612 hsa-mir-125b Sarcopenia However, fold changes of miR5p (FC=2.59) and -23a-3p (FC=2.09) indicated upregulation and miR-125b-5p (FC=0.46) indicated downregulation in the osteoporotic group compared to the non-osteoporotic group. +other 30408612 hsa-mir-125b Osteoporosis However, fold changes of miR5p (FC=2.59) and -23a-3p (FC=2.09) indicated upregulation and miR-125b-5p (FC=0.46) indicated downregulation in the osteoporotic group compared to the non-osteoporotic group. +other 30408612 hsa-mir-21 Osteoporosis However, fold changes of miR5p (FC=2.59) and -23a-3p (FC=2.09) indicated upregulation and miR-125b-5p (FC=0.46) indicated downregulation in the osteoporotic group compared to the non-osteoporotic group. +other 30408612 hsa-mir-21 Sarcopenia However, fold changes of miR5p (FC=2.59) and -23a-3p (FC=2.09) indicated upregulation and miR-125b-5p (FC=0.46) indicated downregulation in the osteoporotic group compared to the non-osteoporotic group. +genetics_knock down_promote 30408550 hsa-mir-509 Ovarian Neoplasms 3p inhibitor decreased cell response to cisplatin (CDDP) and promoted cell survival in SKOV3 ovarian cancer cells. +lncRNA target 30408478 hsa-mir-377 Osteochondritis Dissecans CONCLUSION: lncRNA NEAT1 facilitated the survival and angiogenesis of OGD-induced BMECs via targeting miR-377 and promoting the expression of VEGFA, SIRT1, and BCL-XL, suggesting that lncRNA NEAT1 could be a promising target for cerebral ischaemia treatment. +lncRNA target 30408478 hsa-mir-377 Brain Ischemia CONCLUSION: lncRNA NEAT1 facilitated the survival and angiogenesis of OGD-induced BMECs via targeting miR-377 and promoting the expression of VEGFA, SIRT1, and BCL-XL, suggesting that lncRNA NEAT1 could be a promising target for cerebral ischaemia treatment. +circulation_biomarker_diagnosis_up 30408234 hsa-mir-21 Glioblastoma miR-21 and miR-26a were both significantly upregulated in pre- and postoperation serum samples of glioblastoma patients compared with the serum samples of noncancerous controls. The serum miR-26a and miR-21 upregulation in glioblastoma patients compared to noncancerous controls and their downregulation in postoperative serum from glioblastoma patients suggest that these miRNAs could be used as serum-derived miRNA biomarkers for glioblastoma. +circulation_biomarker_diagnosis_up 30408234 hsa-mir-26a Glioblastoma miR-21 and miR-26a were both significantly upregulated in pre- and postoperation serum samples of glioblastoma patients compared with the serum samples of noncancerous controls. The serum miR-26a and miR-21 upregulation in glioblastoma patients compared to noncancerous controls and their downregulation in postoperative serum from glioblastoma patients suggest that these miRNAs could be used as serum-derived miRNA biomarkers for glioblastoma. +other 30408096 hsa-mir-483 Obesity 5p associates with both diabetes and cardiovascular disease. +other 30408096 hsa-mir-483 Diabetes Mellitus, Type 2 5p associates with both diabetes and cardiovascular disease. +other 30408096 hsa-mir-483 Diabetes Mellitus 5p associates with both diabetes and cardiovascular disease. +other 30408096 hsa-mir-483 Cardiovascular Diseases 5p associates with both diabetes and cardiovascular disease. +transcription factor target 30407707 hsa-mir-520b Carcinoma, Non-Small-Cell Lung Collectively, our findings unveil that miR-520b promotes NSCLC tumourigenesis through SPOP-GLI2/3 axis and provide miR-520b as a potential diagnostic biomarker and therapeutic target for NSCLC. +genetics_knock down_suppress 30407674 hsa-mir-193a Colorectal Neoplasms Furthermore, NEAT1 was confirmed to act as a sponge of miR-193a, and knockdown of NEAT1 attenuated miR-193a inhibitor-induced tumour promoting effects and L17RD expression in CRC cells. +transcription factor target 30407643 hsa-mir-128 Osteosarcoma These data indicate that the miR-128 and its target gene NAIF1 played important roles by regulating OS cell proliferation and migration phenotype. The data of this study indicated that the miR-128 and its target gene NAIF1 played important roles by regulating OS cell proliferation and migration phenotype. +genetics_GWAS 30407537 hsa-mir-762 Arthritis, Rheumatoid hsa-miR-762) by integrating differentially expressed miRNAs with MIGWAS results for RA, as well as novel associated loci with significant genetic risk (rs56656810 at MIR762 at 16q11; n = 91 482, P = 3.6 10-8). +lncRNA target 30407372 hsa-mir-190b Muscular Atrophy CONCLUSION: Burn injury induced skeletal muscle cell autophagy and subsequently resulted in skeletal muscle wasting via regulating miR-190b/PHLPP1/Akt/FoxO3a signaling pathway. +other 30406875 hsa-mir-210 Squamous Cell Carcinoma of Head and Neck Evaluation of HIF-1alpha and miR-210 levels in OSCC was performed. +other 30406874 hsa-mir-204 Breast Neoplasms The expression of miR-204 was decreased, while AREG and p-AKT was increased in T3 stimulated BC cell lines. +transcription factor target 30406154 hsa-mir-96 Schistosomiasis japonica Here, we show that the host miRNA, miR-96, is markedly upregulated during the progression of hepatic schistosomiasis. Taken together, our data highlight the potential for rAAV8-mediated inhibition of miR-96 as a therapeutic strategy to treat hepatic schistosomiasis. +tissue_expression_ns 30406061 hsa-mir-27b Asthma A down-expression of miRNA-27b-3p in dust mite induced asthma group (group D) was found by microarray analysis. +lncRNA target 30406026 hsa-mir-183 Mesothelioma Our previous study showed that miR-182 and miR-183 are upregulated in malignant mesothelioma. Targeting the miR-182/183-FOXO1 axis could serve as a novel treatment against malignant mesothelioma. +lncRNA target 30406026 hsa-mir-182 Mesothelioma Our previous study showed that miR-182 and miR-183 are upregulated in malignant mesothelioma. Targeting the miR-182/183-FOXO1 axis could serve as a novel treatment against malignant mesothelioma. +genetics_overexpression_promote 30405849 hsa-mir-29b Stomach Neoplasms In addition, overexpression of miR-29b significantly decreased the mRNA and protein level of MMP2 and the activity of MMP2 to suppress gastric cancer cell migration. +lncRNA target 30405842 hsa-mir-149 Stomach Neoplasms In conclusion, we found that miR-149 downregulated ZBTB2 and SP1 expressions, and inhibited GC cell progression mediated by GACAT1. +other 30405834 hsa-mir-543 Carcinoma, Renal Cell Therefore, miR-543 could be used as a biomarker for predicting the progression of RCC. +lncRNA target 30405823 hsa-mir-376c Neuroblastoma Ectopic expression of miR-376c-3p led to significant inhibition of cell viability and G1-cell cycle arrest in multiple neuroblastoma cell lines by reducing the expression of cyclin D1, an oncogene critical for neuroblastoma pathogenesis. +genetics_knock down_promote 30405811 hsa-mir-221 Ovarian Neoplasms The overexpression of miR-221 antagonized the apoptosis of ovarian cancer SKOV3 cell and promoted the cell proliferation by targeted inhibition of the expression of BMF, which may serve a role in the pathogenesis of ovarian cancer. +other 30405804 hsa-mir-223 Carcinoma, Non-Small-Cell Lung In the present study, miR-145, miR-20a, miR-21 and miR-223, which were previously reported as candidate diagnostic markers of NSCLC, were re-evaluated. +other 30405804 hsa-mir-20a Carcinoma, Non-Small-Cell Lung In the present study, miR-145, miR-20a, miR-21 and miR-223, which were previously reported as candidate diagnostic markers of NSCLC, were re-evaluated. +other 30405804 hsa-mir-21 Carcinoma, Non-Small-Cell Lung In the present study, miR-145, miR-20a, miR-21 and miR-223, which were previously reported as candidate diagnostic markers of NSCLC, were re-evaluated. +other 30405803 hsa-mir-145 Breast Neoplasms miR-206 and miR-145 may serve as important indicators to predict prognosis of patients with breast cancer in the future. +transcription factor target 30405796 hsa-mir-34a Paranasal Sinus Neoplasms In short, these data demonstrated that miR-34a inhibited SN-SCC cell migration and invasion through targeting BCL-2. +transcription factor target 30405792 hsa-mir-199 Carcinoma, Hepatocellular The effect of miR-199 on the regulation of HCC cell proliferation and its underlying mechanism were examined in Hep3B2.1-7 cells, through expression assays and measurement of cell proliferation (via Cell Counting Kit-8, and 5-ethynyl-2'-deoxyuridine and DAPI double-staining assays) coupled with gain- and lose- of function experiments. +lncRNA target 30405786 hsa-mir-141 Nasopharyngeal Carcinoma This miR-141/BMI1 axis may serve as a novel pharmacological target in NPC treatment. +genetics_overexpression_promote 30405785 hsa-mir-491 Osteosarcoma In addition, PKM2 overexpression reversed the proliferation-inhibiting effects of miR +transcription factor target 30405775 hsa-mir-143 Uterine Cervical Neoplasms We also found that the miRNA-143 expression negatively correlated with the GOLM1 expression in cervical cancer tissues and miRNA-143 inhibited cell invasion and migration via targeting GOLM1 in cervical cancer. +genetics_knock down_suppress 30405773 hsa-mir-140 Stomach Neoplasms Gain- and loss-of-function assays revealed that increased miR +genetics_knock down_promote 30405772 hsa-mir-194 Stomach Neoplasms Taken together, the in vitro experiments revealed that knockdown of SOX2OT inhibited cell proliferation and mobility through suppressing EMT via targeting miR +genetics_overexpression_suppress 30405771 hsa-mir-145 Urinary Bladder Neoplasms 5p overexpression inhibited cell proliferation and migration in BC. +other 30405764 hsa-mir-661 Carcinoma, Pancreatic Ductal Thus, the results of the present study indicated that miR-661 may function as a prognostic marker and provide insight for pancreatic cancer treatment. +lncRNA target 30405753 hsa-mir-24 Stomach Neoplasms The expression of miR-24 and miR-101 in gastric cancer and cancer-adjacent normal tissues were detected via reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and the correlation of the levels of miR-24 and miR-101 in gastric cancer tissues with their clinical and pathological features were explored. +lncRNA target 30405753 hsa-mir-101 Stomach Neoplasms The expression of miR-24 and miR-101 in gastric cancer and cancer-adjacent normal tissues were detected via reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and the correlation of the levels of miR-24 and miR-101 in gastric cancer tissues with their clinical and pathological features were explored. +circulation_biomarker_diagnosis_ns 30405345 hsa-mir-122 Stroke Aim: Our previous study demonstrated miR-122 mimic decreased NOS2 expression in blood leucocytes and improved stroke outcomes when given immediately after middle cerebral artery occlusion (MCAO) in rats. +other 30405317 hsa-mir-127 Pneumonia, Mycoplasma 3p) were identified in adenovirus-infected children and provided a clear distinction between infected and healthy individuals. +other 30405317 hsa-mir-409 Pneumonia, Mycoplasma 3p) were identified in adenovirus-infected children and provided a clear distinction between infected and healthy individuals. +other 30405317 hsa-mir-493 Pneumonia, Mycoplasma 3p) were identified in adenovirus-infected children and provided a clear distinction between infected and healthy individuals. +genetics_knock down_promote 30404587 hsa-mir-193b Stomach Neoplasms In vivo experiments further validated that linc00152 knockdown inhibited the growth of GC xenograft tumors by upregulating miR-193b-3p and downregulating ETS1. +lncRNA target 30404578 hsa-mir-4735 Urinary Bladder Neoplasms Additionally, NOTCH2 mRNA could be targeted by miR +other 30403658 hsa-mir-10b Stomach Neoplasms CONCLUSIONS The high expressions of miR-10b and miR-181b are significantly correlated with poor prognosis in stage II and III patients with gastric cancer, suggesting that their expressions might be criteria for evaluating the prognosis of gastric cancer. +other 30403658 hsa-mir-181b Stomach Neoplasms CONCLUSIONS The high expressions of miR-10b and miR-181b are significantly correlated with poor prognosis in stage II and III patients with gastric cancer, suggesting that their expressions might be criteria for evaluating the prognosis of gastric cancer. +lncRNA target 30403591 hsa-mir-122 Nasopharyngeal Carcinoma Human NPC cell line (HONE-1) was transfected with miR-122 inhibitor (anti-miR-122 group), negative controls (vector control group) via lipofectamines, and HONE-1 cell lines undergoing no transfection were selected (non-transfection group). +other 30403388 hsa-mir-132 Hypertrophy INTRODUCTION AND METHODS: The effects of diazoxide on cardiac hypertrophy and miR-132 expression were characterized in adult rats and in cardiomyocytes. CONCLUSIONS: Our data first demonstrate that diazoxide mitigates hypertrophy by preventing an increase in miR-132 expression. +other 30403259 hsa-mir-1 Colorectal Neoplasms "In addition, we found that miR-31 could recognize hsa_circ_0000523 sequence and that it acted as a ""sponge"" of miR-31, indirectly regulating Wnt/beta-catenin signaling pathway, which was involved in the progression of colorectal cancer. In addition, as a sponge of miR-31, the low level of hsa_circ_0000523 led to activation of Wnt/beta-catenin signaling pathway, inducing the subsequent progress of colorectal cancer." +tissue_expression_ns 30403177 hsa-mir-25 Melanoma In this study, we have evaluated the function of miR-25 in melanoma. First, we examined the expression of miR-25 in four melanoma cell lines (A875, MV3, M14 and uacc-257) and in a normal melanocyte cell line (HEM-a). +transcription factor target 30402852 hsa-mir-126 Multiple Myeloma CONCLUSIONS: MiR-126 induces Karpas707 cell apoptosis by downregulating anti-apoptotic protein MCL, which provides a theoretical basis for the target selection of myeloma. +genetics_overexpression_promote 30402849 hsa-mir-24 Lung Neoplasms In vitro experiments demonstrated that miR-24 overexpression promoted the viability, proliferation and cell cycle of lung carcinoma cells, whereas inhibited cell apoptosis. +genetics_knock down_promote 30402848 hsa-mir-211 Lung Neoplasms 3p knockdown. +genetics_overexpression_promote 30402845 hsa-mir-556 Esophageal Squamous Cell Carcinoma 3p overexpression in EC cells remarkably promoted cell viability. +lncRNA target 30402842 hsa-mir-150 Colonic Neoplasms CONCLUSIONS We observed that miR-150 down-regulated Cyclin A expression to block colorectal cancer cell cycle and inhibit proliferation through targeted inhibiting HMGA2. +genetics_overexpression_promote 30402839 hsa-mir-128 Carcinoma, Hepatocellular 3p overexpression sensitized HCC to sorafenib-induced apoptosis via PTEN/PI3K/Akt signaling pathway by regulating DJ-1 expression. +other 30402833 hsa-mir-124 ankylosing spondylitis 1 RESULTS: MiR-124 and beta-catenin expressions in the ligament of AS patients increased, while GSK-3beta level reduced compared with control. CONCLUSIONS: MiR-124 decreased and GSK-3beta elevated in AS ligament tissue. +lncRNA target 30402831 hsa-mir-517 Pre-Eclampsia 5p is highly expressed in placenta samples of preeclampsia pregnancies, which could promote proliferative and invasive abilities of JAR cells by inhibiting ERK/MMP-2 pathway. +transcription factor target 30402829 hsa-mir-182 Pre-Eclampsia 5p expression could inhibit the migratory and invasive ability of trophoblast cells through targeted degrading RND3 protein. +other 30402207 hsa-mir-26a Non-alcoholic Fatty Liver Disease This study aimed at assessing the regulatory and protective role of miR-26a on lipid metabolism and progression of NAFLD in human HepG2 cells loaded with free fatty acids (FFA). In conclusion, these findings suggested that miR-26a has a crucial role in regulating fatty acid and cholesterol homeostasis in HepG2 cells, along with the offered protection against the progression of NAFLD in vitro. +other 30402161 hsa-mir-365b Coronary Artery Disease In present study, human coronary artery smooth muscle cells (HCASMCs) were used to explore the function of miR-365b-3p in the coronary atherosclerosis. +other 30402147 hsa-mir-520b Carcinoma, Non-Small-Cell Lung miR-520b expression was downregulated in NSCLC, which was negatively correlated with lymph node metastasis and TNM staging. +circulation_biomarker_diagnosis_ns 30401891 hsa-mir-1290 Pancreatic Carcinoma Our data suggest that the absolute quantification of circulating miR-1290 levels does not allow to select patients at clinical risk of PC for entry into a surveillance program, and underline the methodological challenges still existing in utilizing circulating miRNAs as new promising biomarkers for PC. +other 30401711 hsa-mir-21 Colonic Neoplasms 5p were transferred to colorectal cancer cells by MDE and bound to the BRG1 coding sequence, downregulating expression of BRG1, which has been identified as a key factor promoting the colorectal cancer metastasis, yet is downregulated in metastatic colorectal cancer cells. +other 30401711 hsa-mir-155 Colonic Neoplasms 5p were transferred to colorectal cancer cells by MDE and bound to the BRG1 coding sequence, downregulating expression of BRG1, which has been identified as a key factor promoting the colorectal cancer metastasis, yet is downregulated in metastatic colorectal cancer cells. +lncRNA target 30400755 hsa-mir-27b Prostatic Neoplasms, Castration-Resistant The aim of this study was to evaluate the role of the microRNAs-23b/-27b as well as the possible CCNG1 target gene in tissue samples from patients with localized prostate cancer that progressed to castration-resistant prostate cancer and in a castration-resistant prostate cancer cell line (PC-3). +lncRNA target 30400755 hsa-mir-23b Prostatic Neoplasms, Castration-Resistant The aim of this study was to evaluate the role of the microRNAs-23b/-27b as well as the possible CCNG1 target gene in tissue samples from patients with localized prostate cancer that progressed to castration-resistant prostate cancer and in a castration-resistant prostate cancer cell line (PC-3). +other 30400037 hsa-mir-132 Obesity One of these microRNAs, miR-132, is highly induced in several obesity models and increased expression of miR-132 in vitro modulates glucose-stimulated insulin secretion. This suggests that increased miR-132 expression is beneficial for beta cell function during hyperglycemia and obesity. +other 30400037 hsa-mir-132 Hyperglycemia This suggests that increased miR-132 expression is beneficial for beta cell function during hyperglycemia and obesity. +genetics_overexpression_promote 30399596 hsa-mir-383 Ovarian Neoplasms However, overexpressed TRIM27 by pcDNA3.1-TRIM27 transfection counteracted the inhibitory effect of miR +circulation_biomarker_diagnosis_up 30399324 hsa-mir-155 Thyroiditis, Subacute Our results demonstrated that serum TNF-alpha and miR +other 30399176 hsa-mir-497 Melanoma CONCLUSIONS: EV miRNAs let-7g-5p and miR5p were identified as putative novel predictive biomarkers of MAPKi treatment benefit in metastatic CMM patients highlighting the potential relevance of assessing EV miRNA during and after treatment to unravel novel mechanisms of resistance. +lncRNA target 30398231 hsa-mir-133b Corneal Injuries Herein, we introduced nanocomplexes of gold nanoparticles (AuNPs) and microRNA-133b (miR-133b) into collagen-based material to achieve corneal repair and scar inhibition. Our results thus suggest that collagen membranes combined with AuNP/miR-133b complexes can rapidly repair corneas and effectively inhibit scar formation. +lncRNA target 30398231 hsa-mir-133b Cicatrix Herein, we introduced nanocomplexes of gold nanoparticles (AuNPs) and microRNA-133b (miR-133b) into collagen-based material to achieve corneal repair and scar inhibition. Our results thus suggest that collagen membranes combined with AuNP/miR-133b complexes can rapidly repair corneas and effectively inhibit scar formation. +circulation_biomarker_diagnosis_ns 30398001 hsa-mir-141 Lupus Nephritis MATERIALS AND METHODS: This study evaluated miR-16, miR-21, miR-141, miR-146a, and miR-155 expression levels in peripheral blood mononuclear cells (PBMCs) of 55 female SLE patients with absent, inactive, or active nephritis, and 30 healthy controls (HCs) using quantitative polymerase chain reaction. +circulation_biomarker_diagnosis_up 30398001 hsa-mir-155 Lupus Nephritis MATERIALS AND METHODS: This study evaluated miR-16, miR-21, miR-141, miR-146a, and miR-155 expression levels in peripheral blood mononuclear cells (PBMCs) of 55 female SLE patients with absent, inactive, or active nephritis, and 30 healthy controls (HCs) using quantitative polymerase chain reaction. RESULTS: MiR-21 and miR-155 levels were significantly greater in the active nephritis group than in the absent, inactive or HC groups. +circulation_biomarker_diagnosis_up 30398001 hsa-mir-21 Lupus Nephritis MATERIALS AND METHODS: This study evaluated miR-16, miR-21, miR-141, miR-146a, and miR-155 expression levels in peripheral blood mononuclear cells (PBMCs) of 55 female SLE patients with absent, inactive, or active nephritis, and 30 healthy controls (HCs) using quantitative polymerase chain reaction. RESULTS: MiR-21 and miR-155 levels were significantly greater in the active nephritis group than in the absent, inactive or HC groups. +circulation_biomarker_diagnosis_ns 30398001 hsa-mir-146a Lupus Nephritis MATERIALS AND METHODS: This study evaluated miR-16, miR-21, miR-141, miR-146a, and miR-155 expression levels in peripheral blood mononuclear cells (PBMCs) of 55 female SLE patients with absent, inactive, or active nephritis, and 30 healthy controls (HCs) using quantitative polymerase chain reaction. +circulation_biomarker_diagnosis_ns 30398001 hsa-mir-16 Lupus Nephritis MATERIALS AND METHODS: This study evaluated miR-16, miR-21, miR-141, miR-146a, and miR-155 expression levels in peripheral blood mononuclear cells (PBMCs) of 55 female SLE patients with absent, inactive, or active nephritis, and 30 healthy controls (HCs) using quantitative polymerase chain reaction. +genetics_GWAS 30397325 hsa-mir-137 Child Development Disorders, Pervasive Genetic analyses have linked microRNA-137 (MIR137) to neuropsychiatric disorders, including schizophrenia and autism spectrum disorder. +genetics_GWAS 30397325 hsa-mir-137 Mental Disorders Genetic analyses have linked microRNA-137 (MIR137) to neuropsychiatric disorders, including schizophrenia and autism spectrum disorder. Collectively, our results suggest that MIR137 plays essential roles in postnatal neurodevelopment and that dysregulation of miR-137 potentially contributes to neuropsychiatric disorders in humans. +genetics_GWAS 30397325 hsa-mir-137 Schizophrenia Genetic analyses have linked microRNA-137 (MIR137) to neuropsychiatric disorders, including schizophrenia and autism spectrum disorder. +exosome 30397255 hsa-mir-486 Brain Ischemia These data indicate that ECFC exosomes selectively target the kidneys after ischemic injury, with rapid cellular transfer of miR486-5p. +genetics_knock down_promote 30397150 hsa-mir-182 Prostatic Hyperplasia 96-182 overexpression, ZIP1 down-regulation, prostatic Zn loss, and the resultant citrate down-regulation, changes mimicking features of human prostate cancer. +genetics_knock down_suppress 30397150 hsa-mir-183 Prostatic Hyperplasia The discovery that the Zn-depleted middle-aged rat prostate has a metabolic phenotype resembling that of human prostate cancer, with a 10-fold down-regulation of citric acid (P = 0.0003), links citrate reduction directly to prostatic Zn loss, providing the underlying mechanism linking dietary Zn deficiency with miR96-182 overexpression, ZIP1 down-regulation, prostatic Zn loss, and the resultant citrate down-regulation, changes mimicking features of human prostate cancer. +other 30396951 hsa-mir-107 Lung Neoplasms CONCLUSION: Our findings unveil an important biological function of miR-107 in regulating lung cancer cell proliferation and elevating an antiproliferative effect of parthenolide on lung cancer cells, suggesting that miR-107 could be beneficial benefit treatment for advanced NSCLC. +other 30396951 hsa-mir-107 Carcinoma, Non-Small-Cell Lung RESULTS: Cell proliferation was repressed in A549 NSCLC cells transfected with miR-107. CONCLUSION: Our findings unveil an important biological function of miR-107 in regulating lung cancer cell proliferation and elevating an antiproliferative effect of parthenolide on lung cancer cells, suggesting that miR-107 could be beneficial benefit treatment for advanced NSCLC. +genetics_knock down_promote 30396754 hsa-mir-17 Osteosarcoma In addition, knockdown of miR-17 increased the protein expression of SASH1, and regulate related genes of cell proliferation, invasion and anti-apoptosis in the downstream of OS cells. +circulation_biomarker_diagnosis_up 30396333 hsa-mir-99a Ovarian Neoplasms CONCLUSIONS: Serum miR-99a-5p is significantly elevated in ovarian cancer patients. +lncRNA target 30396185 hsa-mir-19b Multiple Myeloma CONCLUSION: These findings collectively suggest that miR-19b promotes cell survival and suppresses apoptosis of MM CSCs via targeting TSC1 directly, indicating that miR-19b may serve as a potential and novel therapeutic target of MM based on miRNA expression. +genetics_overexpression_promote 30396078 hsa-mir-1 Colorectal Neoplasms 5p and NUMB overexpression inhibited the cell proliferation, migration, invasion and induced cell cycle arrest and apoptosis in HT29 colorectal cancer cells. +transcription factor target 30396069 hsa-mir-221 Pre-Eclampsia 3p promoted trophoblast growth, invasion and migration partly via targeting THBS2. +other 30395908 hsa-mir-153 Leukemia, Myeloid, Acute 5p-XIAP axis. +other 30395908 hsa-mir-183 Leukemia, Myeloid, Acute 5p-XIAP axis. +genetics_overexpression_promote 30395767 hsa-mir-132 Colorectal Neoplasms Overexpression of SNHG5 and CREB5 resulted in the enhancement of proliferation, metastasis, migration and the inhibition of apoptosis in CRC cells, while miR +lncRNA target 30394883 hsa-mir-181a Carcinoma, Pancreatic Ductal Inhibition of miR-181a-5p coupled with oxaliplatin exposure in pancreatic cell lines decreased cell viability. +transcription factor target 30394829 hsa-mir-191 Reperfusion Injury, Renal Ischemia Therefore, CBS was a direct target of miR-191, and miR-191 could transfer to HK-2 cells via P-MVs to decrease the expression of CBS, thus to promote cell apoptosis and renal IR injury. +lncRNA target 30394818 hsa-mir-139 Carcinoma, Hepatocellular 3p target genes ISG20L2, RAD54B, KIAA0101, and PIGS were related to HCC prognosis. +other 30394668 hsa-mir-197 Squamous Cell Carcinoma of Head and Neck Validation experiments confirmed the associated functions of SNHG20/miR-197/LIN28 axis on OSCC proliferation and stemness. In summary, our results reveal the important function of SNHG20/miR-197/LIN28 axis in the oncogenesis and stemness of OSCC, suggesting the vital role of SNHG20 in OSCC tumorigenesis. +circRNA target 30394366 hsa-mir-669 Diabetic Nephropathies CONCLUSIONS TSF may be effective for DKD by inhibiting Racgap1-stata5-mediated cell proliferation and restoring miR-669j-Arntl-related circadian rhythm. +transcription factor target 30394333 hsa-mir-128 Glucocorticoid Receptor Deficiency Collectively, these results indicate that miR-128 plays a role in the pathogenesis of glucocorticoid-related abnormal lipid accumulation via repressing SIRT1 expression, consequently, miR-128 inhibition may represent a novel potential therapeutic target in preventing DEX-induced abnormal lipid accumulation. +genetics_overexpression_promote 30394221 hsa-mir-214 Glioblastoma CONCLUSION: Overexpression of miR +other 30393877 hsa-mir-708 Leukemia, Biphenotypic, Acute 5p, and miR-29c-5p) were upregulated in childhood T-ALL. +other 30393877 hsa-mir-29c Leukemia, Biphenotypic, Acute Further studies are needed to assure the role of the 16 miRNAs and miR-29c-5p on acute lymphoblastic leukemia subtypes and on disease prognosis. +other 30393877 hsa-mir-371b Leukemia, Biphenotypic, Acute 5p, and miR-29c-5p) were upregulated in childhood T-ALL. +other 30393877 hsa-mir-455 Leukemia, Biphenotypic, Acute 5p, and miR-29c-5p) were upregulated in childhood T-ALL. +other 30393877 hsa-mir-151a Leukemia, Biphenotypic, Acute 5p, and miR-29c-5p) were upregulated in childhood T-ALL. +other 30393877 hsa-mir-497 Leukemia, Biphenotypic, Acute 5p, and miR-29c-5p) were upregulated in childhood T-ALL. +other 30393877 hsa-mir-424 Leukemia, Biphenotypic, Acute 5p, and miR-29c-5p) were upregulated in childhood T-ALL. +other 30393877 hsa-mir-151b Leukemia, Biphenotypic, Acute 5p, and miR-29c-5p) were upregulated in childhood T-ALL. +other 30393877 hsa-mir-450b Leukemia, Biphenotypic, Acute 5p, and miR-29c-5p) were upregulated in childhood T-ALL. +other 30393877 hsa-mir-450a Leukemia, Biphenotypic, Acute 5p, and miR-29c-5p) were upregulated in childhood T-ALL. +lncRNA target 30393487 hsa-mir-203a Multiple Myeloma CONCLUSIONS: In the present study, we found that lncRNA PVT1 could promote MM cell proliferation and induce cell apoptosis by inhibiting miR-203a expression. +lncRNA target 30393486 hsa-mir-216b Pancreatic Carcinoma In this study, we explore how miR-216b affected human pancreatic cancer cell development by targeting KRAS. +lncRNA target 30393368 hsa-mir-32 Carcinoma, Hepatocellular CONCLUSIONS Our data indicate that miR-32 accelerates progression in HCC by targeting ADAMTS9, and the abnormal expression of miR-32 is correlated with prognosis and could become a potential therapeutic target. +lncRNA target 30393198 hsa-mir-23a Colorectal Neoplasms Here, we show that three miRNAs in the miR-23a approximately 27a approximately 24 cluster, miR-23a, miR-27a and miR-24, are the most upregulated miRNA cluster in colorectal cancer (CRC) under hypoxia. Our findings reveal that the miR-23a approximately 27a approximately 24 cluster is critical regulator switching CRC metabolism from oxidative phosphorylation to glycolysis, and controlling their expression can suppress colorectal cancer progression. +transcription factor target 30393117 hsa-mir-944 Colorectal Neoplasms Taken together, our results suggest that miR-944 acts as a potential tumor suppressor in colorectal cancers through the ubiquitin-proteasome system. +other 30393009 hsa-let-7d Pancreatic Diseases Genistein induced the expression of let-7d and might modulate pancreatic fibrosis. +lncRNA target 30393009 hsa-let-7d Fibrosis Genistein substantially induced let-7d and decreased the expression of fibrosis marker along with the inhibition of THBS1. +other 30393009 hsa-let-7d Pancreatic Carcinoma OBJECTIVES: The microRNA (miRNA) let-7d is linked to the formation of pancreatic cancer-related fibrosis. +other 30393009 hsa-let-7d Neoplasms, Fibrous Tissue The correlation between tumor fibrosis and let-7d or THBS1 was estimated using the data from The Cancer Genome Atlas project. +lncRNA target 30392876 hsa-mir-143 Metabolic Diseases 3p-IGF2R pathway as a potential target for the treatment of obesity-associated insulin resistance. +circulation_biomarker_diagnosis_up 30392569 hsa-mir-425 Diabetic Nephropathies In this study, we detected the expression of 9 candidate miRNAs in the plasma exosome samples from 31 HF patients, and found the level of miR-21, miR-425 and miR-744 was altered. Our data demonstrate that miR-425 and miR-744 function as negative regulators of cardiac fibrosis by suppression TGFbeta1 expression, and miR-425 and miR-744 level in the plasma exosomes has the potential to be a biomarker to predict cardiac fibrosis and heart failure. +circulation_biomarker_diagnosis_up 30392569 hsa-mir-744 Heart Failure In this study, we detected the expression of 9 candidate miRNAs in the plasma exosome samples from 31 HF patients, and found the level of miR-21, miR-425 and miR-744 was altered. Our data demonstrate that miR-425 and miR-744 function as negative regulators of cardiac fibrosis by suppression TGFbeta1 expression, and miR-425 and miR-744 level in the plasma exosomes has the potential to be a biomarker to predict cardiac fibrosis and heart failure. +circulation_biomarker_diagnosis_up 30392569 hsa-mir-744 Diabetic Nephropathies In this study, we detected the expression of 9 candidate miRNAs in the plasma exosome samples from 31 HF patients, and found the level of miR-21, miR-425 and miR-744 was altered. Our data demonstrate that miR-425 and miR-744 function as negative regulators of cardiac fibrosis by suppression TGFbeta1 expression, and miR-425 and miR-744 level in the plasma exosomes has the potential to be a biomarker to predict cardiac fibrosis and heart failure. +circulation_biomarker_diagnosis_up 30392569 hsa-mir-425 Heart Failure In this study, we detected the expression of 9 candidate miRNAs in the plasma exosome samples from 31 HF patients, and found the level of miR-21, miR-425 and miR-744 was altered. Our data demonstrate that miR-425 and miR-744 function as negative regulators of cardiac fibrosis by suppression TGFbeta1 expression, and miR-425 and miR-744 level in the plasma exosomes has the potential to be a biomarker to predict cardiac fibrosis and heart failure. +lncRNA target 30392566 hsa-mir-26b Small Cell Lung Carcinoma Additionally, transfection with miR-26b mimic could inhibit proliferation, colony formation, and migration, as well as induce apoptosis in these SCLC cell lines; while miR-26b inhibitor showed the opposite effects. +other 30392041 hsa-mir-493 Ovarian Neoplasms MiR3p mimic transfection leads to the induction of apoptosis causing the breakdown of mitochondrial membrane potential and the activation of Caspases resulting in the fragmentation of DNA in several ovarian carcinoma cell lines. +lncRNA target 30391932 hsa-mir-23a Graves Disease GD Tregs exhibited weaker suppressive activity, miR-23a-3p mimic suppressed SIRT1 expression and suppressive-activity of Tregs whereas it promoted the expression and acetylation level of FOXP3 in the GD group. +other 30391930 hsa-mir-5590 Breast Neoplasms RT-qPCR results indicated that hsa-miR3p is significantly downregulated in breast tumor tissues (late stage) compared to their normal pairs. +transcription factor target 30391496 hsa-mir-133b Carcinoma, Hepatocellular The miRNA-133b/ SF3B4 axis may serve as a new therapeutic target for HCC treatment. +lncRNA target 30391432 hsa-mir-140 Corneal dystrophy, epithelial basement membrane In summary, SNHG1 promoted GC cell proliferation and invasion via modulating the miR-140/ADAM10 axis. +transcription factor target 30391331 hsa-mir-27a Vesicular Stomatitis Four miR-27a binding sites were recognized in the MAVS 3'UTR, and treatment of miR-27a inhibited MAVS expression and promoted the replication of the vesicular stomatitis virus (VSV). +transcription factor target 30391331 hsa-mir-27a Sexually Transmitted Diseases, Viral Four miR-27a binding sites were recognized in the MAVS 3'UTR, and treatment of miR-27a inhibited MAVS expression and promoted the replication of the vesicular stomatitis virus (VSV). +lncRNA target 30390708 hsa-mir-193b Stomach Neoplasms hsa-miR-193b-3p and hsa-miR-148a-3p, which targeted most DEGs, were highlighted in the DE-miRNA-DEG regulatory network, as well as hsa-miR-1179, which targeted KNL1, was newly predicted to be associated with GC. +circulation_biomarker_diagnosis_up 30390344 hsa-mir-93 Breast Neoplasms In the qPCR validation test, the serum levels of miR-93 were upregulated in breast cancer, breast hyperplasia, lung cancer, chronic obstructive pulmonary disease, nasopharyngeal cancer, hepatocellular cancer, gastric ulcer, endometrial cancer, esophageal cancer, laryngeal cancer, and prostate cancer compared with healthy controls. +circulation_biomarker_diagnosis_up 30390344 hsa-mir-93 Laryngeal Neoplasms In the qPCR validation test, the serum levels of miR-93 were upregulated in breast cancer, breast hyperplasia, lung cancer, chronic obstructive pulmonary disease, nasopharyngeal cancer, hepatocellular cancer, gastric ulcer, endometrial cancer, esophageal cancer, laryngeal cancer, and prostate cancer compared with healthy controls. +circulation_biomarker_diagnosis_up 30390344 hsa-mir-93 Endometrial Neoplasms In the qPCR validation test, the serum levels of miR-93 were upregulated in breast cancer, breast hyperplasia, lung cancer, chronic obstructive pulmonary disease, nasopharyngeal cancer, hepatocellular cancer, gastric ulcer, endometrial cancer, esophageal cancer, laryngeal cancer, and prostate cancer compared with healthy controls. +circulation_biomarker_diagnosis_up 30390344 hsa-mir-93 Lung Neoplasms In the qPCR validation test, the serum levels of miR-93 were upregulated in breast cancer, breast hyperplasia, lung cancer, chronic obstructive pulmonary disease, nasopharyngeal cancer, hepatocellular cancer, gastric ulcer, endometrial cancer, esophageal cancer, laryngeal cancer, and prostate cancer compared with healthy controls. +circulation_biomarker_diagnosis_up 30390344 hsa-mir-93 Carcinoma, Hepatocellular In the qPCR validation test, the serum levels of miR-93 were upregulated in breast cancer, breast hyperplasia, lung cancer, chronic obstructive pulmonary disease, nasopharyngeal cancer, hepatocellular cancer, gastric ulcer, endometrial cancer, esophageal cancer, laryngeal cancer, and prostate cancer compared with healthy controls. +circulation_biomarker_diagnosis_up 30390344 hsa-mir-93 Stomach Ulcer In the qPCR validation test, the serum levels of miR-93 were upregulated in breast cancer, breast hyperplasia, lung cancer, chronic obstructive pulmonary disease, nasopharyngeal cancer, hepatocellular cancer, gastric ulcer, endometrial cancer, esophageal cancer, laryngeal cancer, and prostate cancer compared with healthy controls. +circulation_biomarker_diagnosis_up 30390344 hsa-mir-93 Nasopharyngeal Neoplasms In the qPCR validation test, the serum levels of miR-93 were upregulated in breast cancer, breast hyperplasia, lung cancer, chronic obstructive pulmonary disease, nasopharyngeal cancer, hepatocellular cancer, gastric ulcer, endometrial cancer, esophageal cancer, laryngeal cancer, and prostate cancer compared with healthy controls. +circulation_biomarker_diagnosis_up 30390344 hsa-mir-93 Esophageal Neoplasms In the qPCR validation test, the serum levels of miR-93 were upregulated in breast cancer, breast hyperplasia, lung cancer, chronic obstructive pulmonary disease, nasopharyngeal cancer, hepatocellular cancer, gastric ulcer, endometrial cancer, esophageal cancer, laryngeal cancer, and prostate cancer compared with healthy controls. +circulation_biomarker_diagnosis_up 30390344 hsa-mir-93 Pulmonary Disease, Chronic Obstructive In the qPCR validation test, the serum levels of miR-93 were upregulated in breast cancer, breast hyperplasia, lung cancer, chronic obstructive pulmonary disease, nasopharyngeal cancer, hepatocellular cancer, gastric ulcer, endometrial cancer, esophageal cancer, laryngeal cancer, and prostate cancer compared with healthy controls. +circulation_biomarker_diagnosis_up 30390344 hsa-mir-93 Gigantomastia In the qPCR validation test, the serum levels of miR-93 were upregulated in breast cancer, breast hyperplasia, lung cancer, chronic obstructive pulmonary disease, nasopharyngeal cancer, hepatocellular cancer, gastric ulcer, endometrial cancer, esophageal cancer, laryngeal cancer, and prostate cancer compared with healthy controls. +circulation_biomarker_diagnosis_up 30390344 hsa-mir-93 Prostatic Neoplasms In the qPCR validation test, the serum levels of miR-93 were upregulated in breast cancer, breast hyperplasia, lung cancer, chronic obstructive pulmonary disease, nasopharyngeal cancer, hepatocellular cancer, gastric ulcer, endometrial cancer, esophageal cancer, laryngeal cancer, and prostate cancer compared with healthy controls. +transcription factor target 30390343 hsa-mir-124 Neuralgia 3p was able to promote neuroinflammation and neuropathic pain through targeting EZH2. +other 30390341 hsa-mir-130 Osteoarthritis RESULTS: lncRNA-CIR is significantly upregulated in OA patients, accompanied by downregulation of miR-130a and upregulation of Bim. CONCLUSIONS: The present findings demonstrated that the lncRNA-CIR/miR-130a/Bim axis is involved in oxidative stress-related apoptosis of chondrocytes in OA. +other 30390341 hsa-mir-130a Osteoarthritis RESULTS: lncRNA-CIR is significantly upregulated in OA patients, accompanied by downregulation of miR-130a and upregulation of Bim. CONCLUSIONS: The present findings demonstrated that the lncRNA-CIR/miR-130a/Bim axis is involved in oxidative stress-related apoptosis of chondrocytes in OA. +lncRNA target 30390332 hsa-mir-125b Precursor Cell Lymphoblastic Leukemia-Lymphoma CONCLUSIONS: miR-125b and Bcl-2 together are potent predictors for the prognosis and, therefore, can be used as therapeutic targets in childhood ALL. +genetics_overexpression_promote 30390327 hsa-mir-384 Carcinoma, Renal Cell In addition, overexpression of miR-384 suppressed RCC cell proliferation, cell cycle, and cell migration. +genetics_overexpression_promote 30390072 hsa-mir-411 Carcinoma, Non-Small-Cell Lung 5p/3p overexpression could accelerate cell proliferation and migration, and impede cell apoptosis in NSCLC cell lines. +transcription factor target 30390072 hsa-mir-411 Lung Neoplasms SPRY4-AKT axis might act as a promising target for lung cancer therapy clinically. +genetics_overexpression_promote 30390072 hsa-mir-411 Carcinoma, Small Cell 5p/3p overexpression could accelerate cell proliferation and migration, and impede cell apoptosis in NSCLC cell lines. +lncRNA target 30389902 hsa-mir-15a Pituitary Neoplasms Alterations in miRNA expression, including downregulation of three putative 'tumour suppressor' miRNAs, miR-15a, miR +lncRNA target 30389902 hsa-mir-16-1 Pituitary Neoplasms Alterations in miRNA expression, including downregulation of three putative 'tumour suppressor' miRNAs, miR-15a, miR +lncRNA target 30389902 hsa-let-7a Pituitary Neoplasms Alterations in miRNA expression, including downregulation of three putative 'tumour suppressor' miRNAs, miR-15a, miR +transcription factor target 30389900 hsa-mir-93 Prolactinoma Taken together, our results suggest that miRNA-93 mediates CAB resistance via autophagy downregulation by targeting ATG7 and serves as a promising therapeutic target for prolactinoma. +other 30389857 hsa-mir-33a Plaque, Atherosclerotic We showed that miR-200c induces endothelial dysfunction, ROS production and a positive mechanism among miR-200c and miR-33a/b, two miRNAs involved in atherosclerosis progression. +circulation_biomarker_diagnosis_ns 30389857 hsa-mir-200c Plaque, Atherosclerotic Interestingly, 1 month after CEA, circulating miR-200c is low in patients with stable plaques (n=11) and increased to control levels, in patients with unstable plaques (n=13). Our results show that miR-200c is an atherosclerotic plaque progression biomarker and suggest that it may be clinically useful to identify patients at high embolic risk. +genetics_knock down_suppress 30389563 hsa-mir-223 Endomyocardial Fibrosis To explore the role of miR-223 in the process of chicken IMF deposition, loss and gain of function experiments were performed in primary intramuscular preadipocytes using miR-223 mimics, miR-223 inhibitor, and si-GPAM. +lncRNA target 30389560 hsa-mir-1253 Prostatic Neoplasms In conclusion, we confirmed that lncRNA FOXC2-AS1 accelerated the tumor progression of prostate cancer cells by regulating the proliferation and tumor growth through miR-1253/EZH2 axis. +lncRNA target 30389523 hsa-mir-34a Multiple Myeloma Conclusions, RMRP functions as a miR-34a-5p sponge to promote cell proliferation and repress cell apoptosis through upregulation of c-Myc in MM. +genetics_overexpression_promote 30389444 hsa-mir-21 Breast Neoplasms In summary, MEG3 overexpression inhibited the tumorigenesis of breast cancer by downregulating miR-21 through the PI3K/Akt pathway. +lncRNA target 30389433 hsa-mir-1291 Pancreatic Carcinoma AT-rich interacting domain protein 3B (ARID3B) was verified as a new target for miR-1291, and miR-1291 prodrug was processed to mature miR-1291 in PC cells which surprisingly upregulated ARID3B mRNA and protein levels. +lncRNA target 30389318 hsa-mir-449c Carcinoma, Hepatocellular This evidence suggests that miR-449c-5p could play an essential role in HCC through various pathways and that POLD3 could be a potential miR-449c-5p target. +lncRNA target 30389135 hsa-mir-224 Breast Neoplasms Target Scan 7.2 was used to predict biological targets of miR +other 30389133 hsa-mir-153 Breast Neoplasms In conclusion, we validated the positive feedback loop of KLF5/CASC15/miR3p/KLF5 in the acceleration of breast cancer malignant behaviors and tumorigenesis, suggesting the important biologic roles of CASC15 on the breast cancer tumorigenesis. +virus_miRNA 30248542 ebv-mir-BART4 Nasopharyngeal Carcinoma Downregulation of EB virus miR-BART4 inhibits proliferation and aggressiveness while promoting radiosensitivity of nasopharyngeal carcinoma +virus_miRNA 30209170 ebv-mir-BART5 Nasopharyngeal Carcinoma Epstein-Barr Virus MicroRNA miR-BART5-3p Inhibits p53 Expression by directly targeting its 3'-UTR +virus_miRNA 30209170 ebv-mir-BART5 stomach carcinoma Epstein-Barr Virus MicroRNA miR-BART5-3p Inhibits p53 Expression by directly targeting its 3'-UTR +virus_miRNA 30127876 ebv-mir-BART7 Nasopharyngeal Carcinoma Epstein-Barr virus-encoded microRNA BART7 downregulates major histocompatibility complex class I chain-related peptide A and reduces the cytotoxicity of natural killer cells to nasopharyngeal carcinoma +virus_miRNA 29767614 mdv1-mir-M4 Lymphoma higher expression of MDV microRNAs (mdv1-miR-M4-5p and mdv1-miR-M2-3p) in the spleen +virus_miRNA 29767614 mdv1-mir-M2 Lymphoma higher expression of MDV microRNAs (mdv1-miR-M4-5p and mdv1-miR-M2-3p) in the spleen +virus_miRNA 29550353 hsv-mir-H1 Herpes Simplex HSV-1 infection assays showed that miR-H1 can regulate viral entry and infection in human oral keratinocytes (HOK) +virus_miRNA 29330663 hcmv-mir-UL112 Vascular Diseases Human cytomegalovirus-encoded miR-UL112 contributes to HCMV-mediated vascular diseases by inducing vascular endothelial cell dysfunction +virus_miRNA 29185211 ebv-mir-BART2 Kidney Transplantation EBV-miR-BART2-5p, which targets the stress-induced immune ligand MICB to escape recognition and elimination by NK cells, may have a role in sustaining high EBV viral loads in CHL paediatric kidney transplant recipients +circulation_biomarker_diagnosis_down 29179454 hsa-mir-4803 Carcinoma, Non-Small-Cell Lung down regulated in primary (tyrosine kinase inhibitors) resistant patients' plasma. +circulation_biomarker_diagnosis_down 29179454 hsa-mir-548aq Carcinoma, Non-Small-Cell Lung hsa-miR-548aq-5p down regulated in primary (tyrosine kinase inhibitors) resistant patients' plasma. +circulation_biomarker_diagnosis_down 29179454 hsa-mir-138-2 Carcinoma, Non-Small-Cell Lung hsa-miR-138-2-3p down regulated in primary (tyrosine kinase inhibitors) resistant patients' plasma. +circulation_biomarker_diagnosis_down 29179454 hsa-mir-585 Carcinoma, Non-Small-Cell Lung hsa-miR-585-3p down regulated in primary (tyrosine kinase inhibitors) resistant patients' plasma. +circulation_biomarker_diagnosis_down 29179454 hsa-mir-4791 Carcinoma, Non-Small-Cell Lung down regulated in primary (tyrosine kinase inhibitors) resistant patients' plasma. +circulation_biomarker_diagnosis_down 29179454 hsa-mir-72 Carcinoma, Non-Small-Cell Lung hsa-miR-372-5p down regulated in primary (tyrosine kinase inhibitors) resistant patients' plasma. +circulation_biomarker_diagnosis_down 29179454 hsa-mir-4796 Carcinoma, Non-Small-Cell Lung hsa-miR-4796-3p down regulated in primary (tyrosine kinase inhibitors) resistant patients' plasma. +circulation_biomarker_diagnosis_down 29179454 hsa-mir-769 Carcinoma, Non-Small-Cell Lung hsa-miR-769-3p down regulated in primary (tyrosine kinase inhibitors) resistant patients' plasma. +circulation_biomarker_diagnosis_down 29179454 hsa-mir-196 Carcinoma, Non-Small-Cell Lung down regulated in primary (tyrosine kinase inhibitors) resistant patients' plasma. +circulation_biomarker_diagnosis_down 29179454 hsa-mir-16-1 Carcinoma, Non-Small-Cell Lung hsa-miR-16-1-3p down regulated in primary (tyrosine kinase inhibitors) resistant patients' plasma. +virus_miRNA 29179454 hsv2-mir-H19 Carcinoma, Non-Small-Cell Lung down regulated in primary (tyrosine kinase inhibitors) resistant patients' plasma. +virus_miRNA 29179454 ebv-mir-BART14 Carcinoma, Non-Small-Cell Lung ebv-miR-BART14-5p down regulated in primary (tyrosine kinase inhibitors) resistant patients' plasma. +circulation_biomarker_diagnosis_down 29179454 hsa-mir-153 Carcinoma, Non-Small-Cell Lung down regulated in primary (tyrosine kinase inhibitors) resistant patients' plasma. +circulation_biomarker_diagnosis_down 29179454 hsa-mir-744 Carcinoma, Non-Small-Cell Lung hsa-miR-744-5p down regulated in primary (tyrosine kinase inhibitors) resistant patients' plasma. +circulation_biomarker_diagnosis_down 29179454 hsa-mir-1469 Carcinoma, Non-Small-Cell Lung down regulated in primary (tyrosine kinase inhibitors) resistant patients' plasma. +virus_miRNA 29116593 hcmv-mir-US5-1 Human Cytomegalovirus Infections Human cytomegalovirus miR-US5-1 inhibits viral replication by targeting Geminin mRNA +virus_miRNA 28986538 hcmv-mir-US33 Acute Aortic Dissection had significantly higher plasma expression levels of let-7b, miR-15a, miR-23a and hcmv-miR-US33-5p compared with 14 CP patients of 40 controls +virus_miRNA 28765936 hcmv-mir-US4 Human Cytomegalovirus Infections Human cytomegalovirus miR-US4-5p promotes apoptosis via downregulation of p21-activated kinase 2 in cultured cells +virus_miRNA 28746870 hcmv-mir-UL112 Human Cytomegalovirus Infections miR-UL112-5p-Mediated Immunoevasion +virus_miRNA 28592251 hcmv-mir-UL36 Lichen Planus, Oral the plasma levels of five HCMV-encoded miRNAs including hcmv-miR-UL112-3p, hcmv-miR-UL22a-5p, hcmv-miR-UL148d, hcmv-miR-UL36-5p and hcmv-miR-UL59 were significantly increased in OLP patients +virus_miRNA 28592251 hcmv-mir-UL148d Lichen Planus, Oral the plasma levels of five HCMV-encoded miRNAs including hcmv-miR-UL112-3p, hcmv-miR-UL22a-5p, hcmv-miR-UL148d, hcmv-miR-UL36-5p and hcmv-miR-UL59 were significantly increased in OLP patients +virus_miRNA 28592251 hcmv-mir-UL22a Lichen Planus, Oral the plasma levels of five HCMV-encoded miRNAs including hcmv-miR-UL112-3p, hcmv-miR-UL22a-5p, hcmv-miR-UL148d, hcmv-miR-UL36-5p and hcmv-miR-UL59 were significantly increased in OLP patients +virus_miRNA 28592251 hcmv-mir-UL112 Lichen Planus, Oral the plasma levels of five HCMV-encoded miRNAs including hcmv-miR-UL112-3p, hcmv-miR-UL22a-5p, hcmv-miR-UL148d, hcmv-miR-UL36-5p and hcmv-miR-UL59 were significantly increased in OLP patients +virus_miRNA 28592251 hcmv-mir-UL59 Lichen Planus, Oral the plasma levels of five HCMV-encoded miRNAs including hcmv-miR-UL112-3p, hcmv-miR-UL22a-5p, hcmv-miR-UL148d, hcmv-miR-UL36-5p and hcmv-miR-UL59 were significantly increased in OLP patients +virus_miRNA 28468588 hsv2-mir-H9 Lung Neoplasms Reduction of SOCS2 dosage by hsv2-miR-H9-5p induced increased migration and invasion of lung cancer cells. +virus_miRNA 28423621 ebv-mir-BART7 Nasopharyngeal Carcinoma Epstein-Barr virus encoded microRNA BART7 regulates radiation sensitivity of nasopharyngeal carcinoma +virus_miRNA 28253538 ebv-mir-BHRF1-3 Multiple Sclerosis The identification of up-regulated ebv-miR-BHRF1-2-5p targeting MALT1 and ebv-miR-BHRF1-3 in the circulation of patients with multiple sclerosis +virus_miRNA 28253538 ebv-mir-BHRF1-2 Multiple Sclerosis The identification of up-regulated ebv-miR-BHRF1-2-5p targeting MALT1 and ebv-miR-BHRF1-3 in the circulation of patients with multiple sclerosis +virus_miRNA 28148795 hbv-mir-3 Hepatitis B, Chronic HBV-miR-3 targets its transcripts to attenuate HBV replication. +virus_miRNA 27852859 kshv-mir-K9 Sarcoma, Kaposi KSHV miR-K9 protected primary endothelial cells from apoptosis and cell cycle arrest following Nutlin-3 treatment. +virus_miRNA 27816548 ebv-mir-BART6 Purpura, Thrombocytopenic, Idiopathic Modulation of miR-185-5p expression by EBV-miR-BART6 contributes to developmental differences in ABCG4 gene expression in human megakaryocytes +virus_miRNA 27757686 ebv-mir-BART15 Stomach Neoplasms TAX1BP1 downregulation by EBV-miR-BART15-3p enhances chemosensitivity of gastric cancer cells to 5-FU +virus_miRNA 27584792 ebv-mir-BART6 Nasopharyngeal Carcinoma Epstein-Barr virus-encoded miR-BART6-3p inhibits cancer cell metastasis and invasion by targeting long non-coding RNA LOC553103 +virus_miRNA 27575252 ebv-mir-BART19 Adenocarcinoma of Lung ebv-miR-BART19 up regulated by > 5-fold in the non-TRU (terminal respiratory unit) lung adenocarcinoma samples relative to the TRU type. +virus_miRNA 27381477 ebv-mir-BART13 Sjogren's Syndrome Targeting the Ca(2+) Sensor STIM1 by Exosomal Transfer of Ebv-miR-BART13-3p is Associated with Sjögren's Syndrome +virus_miRNA 27248822 kshv-mir-K12-11 Lymphoma, B-Cell KSHV-miR-K12-11 (miR-K12-11) that is unique in having an identical seed sequence with the oncomiR hsa-miR-155, implicated in B cell lymphomas development. +virus_miRNA 27240979 hcmv-mir-US4-1 Human Cytomegalovirus Infections Human cytomegalovirus-encoded miR-US4-1 promotes cell apoptosis and benefits discharge of infectious virus particles by targeting QARS +virus_miRNA 27167345 ebv-mir-BART11 Nasopharyngeal Carcinoma Epstein-Barr virus encoded miR-BART11 promotes inflammation-induced carcinogenesis by targeting FOXP1 +virus_miRNA 26961899 hcmv-mir-US4-1 Hepatitis B, Chronic Circulating human cytomegalovirus-encoded HCMV-miR-US4-1 as an indicator for predicting the efficacy of IFNα treatment in chronic hepatitis B patients +virus_miRNA 26634702 ebv-mir-BHRF16-1 Infectious Mononucleosis EBV-miR-BHRF1-1, 1-2-3P, miR-BART13-1, 19-3p, 11-3P, 12-1, and 16-1 in IM patients of early phase were significantly higher than in healthy children. +virus_miRNA 26634702 ebv-mir-BHRF12-1 Infectious Mononucleosis EBV-miR-BHRF1-1, 1-2-3P, miR-BART13-1, 19-3p, 11-3P, 12-1, and 16-1 in IM patients of early phase were significantly higher than in healthy children. +virus_miRNA 26634702 ebv-mir-BHRF19 Infectious Mononucleosis EBV-miR-BHRF1-1, 1-2-3P, miR-BART13-1, 19-3p, 11-3P, 12-1, and 16-1 in IM patients of early phase were significantly higher than in healthy children. +virus_miRNA 26634702 ebv-mir-BHRF1-2 Infectious Mononucleosis EBV-miR-BHRF1-1, 1-2-3P, miR-BART13-1, 19-3p, 11-3P, 12-1, and 16-1 in IM patients of early phase were significantly higher than in healthy children. +virus_miRNA 26634702 ebv-mir-BHRF1-1 Infectious Mononucleosis EBV-miR-BHRF1-1, 1-2-3P, miR-BART13-1, 19-3p, 11-3P, 12-1, and 16-1 in IM patients of early phase were significantly higher than in healthy children. +virus_miRNA 26530011 ebv-mir-BHRF1-2 Lymphoma The interaction between EBV-miR-BHRF1-2 and PRDM1 may be one of the mechanisms by which EBV-miR-BHRF1-2 promotes EBV lymphomagenesis. +virus_miRNA 26497204 ebv-mir-BART10 Nasopharyngeal Carcinoma EBV-miR-BART10-3p facilitates epithelial-mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma by targeting BTRC +virus_miRNA 26263384 kshv-mir-K2 Sarcoma, Kaposi KSHV miR-K2 and miR-K5 may facilitate KSHV pathogenesis +virus_miRNA 26263384 kshv-mir-K5 Sarcoma, Kaposi KSHV miR-K2 and miR-K5 may facilitate KSHV pathogenesis +virus_miRNA 26212361 hcmv-mir-UL36 Human Cytomegalovirus Infections Human cytomegalovirus miR-UL36-5p inhibits apoptosis via downregulation of adenine nucleotide translocator 3 in cultured cells +virus_miRNA 26126436 hsv1-mir-H9 Prostatic Neoplasms The expression levels of hsa-miR-615-3p, hsv1-miR-H18, hsv2-miR-H9-5p, and hsa-miR-4316 were significantly higher in urine samples of patients with PCa than in those of BPH controls. +virus_miRNA 26126436 hsv1-mir-H18 Prostatic Neoplasms The expression levels of hsa-miR-615-3p, hsv1-miR-H18, hsv2-miR-H9-5p, and hsa-miR-4316 were significantly higher in urine samples of patients with PCa than in those of BPH controls. +virus_miRNA 26055091 hcmv-mir-US25-1 Human Cytomegalovirus Infections Human cytomegalovirus microRNA miR-US25-1-5p inhibits viral replication by targeting multiple cellular genes during infection +virus_miRNA 25955717 hcmv-mir-UL112 Human Cytomegalovirus Infections Human Cytomegalovirus miR-UL112-3p Targets TLR2 and Modulates the TLR2/IRAK1/NFκB Signaling Pathway +virus_miRNA 25833298 hcmv-mir-UL22A Cytomegalovirus Infections Hcmv-miR-UL22A-5p: A Biomarker in Transplantation With Broad Impact on Host Gene Expression and Potential Immunological Implications +virus_miRNA 25791397 kshv-mir-K12-1 Cardiomyopathy, Alcoholic differentially expressed in plasma +virus_miRNA 25740983 ebv-mir-BART4 Stomach Neoplasms The inhibition of ebv-miR-BART4-5p expression was associated with partial recovery of Bid levels in EBV-positive cell lines. +virus_miRNA 25691053 ebv-mir-BART7 Nasopharyngeal Carcinoma Gold nano-particles (AuNPs) carrying anti-EBV-miR-BART7-3p inhibit growth of EBV-positive nasopharyngeal carcinoma +virus_miRNA 25583387 hcmv-mir-US33 Human Cytomegalovirus Infections Human cytomegalovirus miR-US33-5p inhibits viral DNA synthesis and viral replication by down-regulating expression of the host Syntaxin3 +virus_miRNA 25530545 hcmv-mir-UL112 Human Cytomegalovirus Infections Hcmv-miR-UL112 attenuates NK cell activity by inhibition type I interferon secretion +virus_miRNA 25476907 kshv-mir-K12-12 Sepsis Differences related to sepsis etiology were noted for plasma levels of 10 cellular and 2 KSHV miRNAs (miR-K-10b and miR-K-12-12*) +virus_miRNA 25476907 kshv-mir-K10b Sepsis Differences related to sepsis etiology were noted for plasma levels of 10 cellular and 2 KSHV miRNAs (miR-K-10b and miR-K-12-12*) +virus_miRNA 25462570 hcmv-mir-UL112 Glioblastoma A higher prevalence of circulating miR-UL112-3p was detected in DM and GBM patients than in RA patients and HC. Elevated levels of miR-UL112-3p and higher prevalence of HCMV IgG were observed in DM patients. +virus_miRNA 25462570 hcmv-mir-UL112 Diabetes Mellitus A higher prevalence of circulating miR-UL112-3p was detected in DM and GBM patients than in RA patients and HC. Elevated levels of miR-UL112-3p and higher prevalence of HCMV IgG were observed in DM patients. +virus_miRNA 25347742 ebv-mir-BART7 Nasopharyngeal Carcinoma EBV-miR-BART7-3p promotes the EMT and metastasis of nasopharyngeal carcinoma cells by suppressing the tumor suppressor PTEN +virus_miRNA 25266797 kshv-mir-K12-12 Sarcoma, Kaposi upregulated +virus_miRNA 25266797 kshv-mir-k12-1 Sarcoma, Kaposi upregulated +virus_miRNA 24737391 hcmv-mir-UL70 Human Cytomegalovirus Infections HCMV miR-UL70-3p and miR-UL148D have role in overcoming the cellular apoptosis +virus_miRNA 24737391 hcmv-mir-UL148D Human Cytomegalovirus Infections HCMV miR-UL70-3p and miR-UL148D have role in overcoming the cellular apoptosis +virus_miRNA 24314636 mdv1-mir-M4 Lymphoma Virus-encoded miR-155 ortholog is an important potential regulator but not essential for the development of lymphomas induced by very virulent Marek's disease virus +virus_miRNA 24027049 kshv-mir-k12-8 Sarcoma, Kaposi significantly upregulated +virus_miRNA 24027049 kshv-mir-k12-4 Sarcoma, Kaposi significantly upregulated +virus_miRNA 24027049 kshv-mir-k12-1 Sarcoma, Kaposi significantly upregulated +virus_miRNA 24027049 kshv-mir-k12-2 Sarcoma, Kaposi significantly upregulated +virus_miRNA 23938381 hcmv-mir-UL36 Human Cytomegalovirus Infections Down-regulation of human cytomegalovirus UL138, a novel latency-associated determinant, by hcmv-miR-UL36 +virus_miRNA 23747307 hcmv-mir-US25-2 Human Cytomegalovirus Infections Over-expression of human cytomegalovirus miR-US25-2-3p downregulates eIF4A1 and inhibits HCMV replication +virus_miRNA 23709205 hsv1-mir-H7 Keloid significantly up-regulated in keloid fibroblasts +virus_miRNA 23685147 ebv-mir-BART1 Nasopharyngeal Carcinoma EBV-miR-BART1 is involved in regulating metabolism-associated genes in nasopharyngeal carcinoma +virus_miRNA 23554906 ebv-mir-BHRF1 Ovarian Neoplasms ebv-miR-BHRF1-2* was associated with both ovarian cancer survival and recurrence +virus_miRNA 23403649 hcmv-mir-UL148D Human Cytomegalovirus Infections hcmv-mir-UL148D targets the cellular gene, IEX-1, downregulating its expression and thus results in anti-apoptotic effects. +virus_miRNA 23402302 hcmv-mir-UL112 Human Cytomegalovirus Infections The expression of interleukin-32 is activated by human cytomegalovirus infection and down regulated by hcmv-miR-UL112-1 +virus_miRNA 23280823 ebv-mir-BART3 Nasopharyngeal Carcinoma Targeting of DICE1 tumor suppressor by Epstein-Barr virus-encoded miR-BART3* microRNA in nasopharyngeal carcinoma +virus_miRNA 22843893 ebv-mir-BART7 Nasopharyngeal Carcinoma The plasma ebv-miR-BART7 level was significantly higher in patients with NPC in comparison with that from healthy individuals. +virus_miRNA 21924071 hcmv-mir-UL112 Essential Hypertension were up-regulated in the patient whole blood samples. +virus_miRNA 21892175 hcmv-mir-US4-1 Human Cytomegalovirus Infections Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1 +virus_miRNA 21813606 kshv-mir-k12-11 Lymphoma, Primary Effusion miR-K12-11 as a functional ortholog of miR-155 in the context of hematopoiesis and suggests a novel mechanism by which KSHV miR-K12-11 induces splenic B-cell expansion and potentially KSHV-associated lymphomagenesis by targeting C/EBPb. +virus_miRNA 21764682 ebv-mir-BART22 Nasopharyngeal Carcinoma NPC tissues have a lower expression of MAP3K5 but a higher expression of miR-BART22. +virus_miRNA 21690488 hcmv-mir-UL112 Essential Hypertension upregulated in patient plasma samples. +virus_miRNA 20962090 mdv1-mir-M3 Lymphoma MDV1-miR-M3 significantly promoted cell survival under treatment with cisplatin +virus_miRNA 18316607 ebv-mir-BHRF1-3 Lymphoma A markedly elevated expression of miRNA BHRF1-3 in type III relative to its parental type I BL line was found. Primary unmanipulated type I BLs and EBV(+) PELs expressed high levels of BART2 miRNA. +virus_miRNA 18316607 ebv-mir-BART2 Lymphoma A markedly elevated expression of miRNA BHRF1-3 in type III relative to its parental type I BL line was found. Primary unmanipulated type I BLs and EBV(+) PELs expressed high levels of BART2 miRNA. +virus_miRNA 17641203 hcmv-mir-UL112 Human Cytomegalovirus Infections hcmv-miR-UL112 specifically down-regulates MICB expression during viral infection, leading to decreased binding of NKG2D and reduced killing by NK cells. +virus_miRNA 3025828 ebv-mir-BART22 Stomach Neoplasms EBV-miR-BART1-3p and EBV-mir-BART22 were found to be key elements of regulation mechanism of EBVaGC. +virus_miRNA 3025828 ebv-mir-BART1 Stomach Neoplasms EBV-miR-BART1-3p and EBV-mir-BART22 were found to be key elements of regulation mechanism of EBVaGC. diff --git a/modulector/migrations/0035_auto_20230112_2319.py b/modulector/migrations/0035_auto_20230112_2319.py index 831f5b1..310cd68 100644 --- a/modulector/migrations/0035_auto_20230112_2319.py +++ b/modulector/migrations/0035_auto_20230112_2319.py @@ -16,7 +16,7 @@ def import_methylation_epic_v2(apps, _schema_editor): modulector_methylation_gencode: info relating the methylation site to other genetic information such as genes and transcripts according to Gencode """ parent_dir = pathlib.Path(__file__).parent.absolute().parent - db_path = os.path.join(parent_dir, "files/EPIC-8v2-0_A1.csv") # Download DB from Infinium MethylationEPIC v2.0 + db_path = os.path.join(parent_dir, "files/EPIC.csv") # Download DB from Infinium MethylationEPIC v2.0 # Product Files in https://support.illumina.com/array/array_kits/infinium-methylationepic-beadchip-kit/downloads.html print("\nRemoving comments in file...") os.system('tail -n +8 ' + db_path + ' >modulector/files/tmp_db.csv') # Removes first 7 rows diff --git a/modulector/migrations/0036_auto_20230116_2049.py b/modulector/migrations/0036_auto_20230116_2049.py index 2b656d9..87720c9 100644 --- a/modulector/migrations/0036_auto_20230116_2049.py +++ b/modulector/migrations/0036_auto_20230116_2049.py @@ -51,7 +51,7 @@ def import_mirbase(apps, _schema_editor): def import_mirdip(apps, _schema_editor): """It updates the mirDIP database in the table modulector_mirnaxgene. It also adds the miRNAs to the modulector_mirna table, without sequence, in case it is not found. - Columns for file : files/mirDIP_Unidirectional_search_v.5.txt + Columns for file : files/mirDIP_Unidirectional_search.txt GENE_SYMBOL MICRORNA SOURCE_NUMBER @@ -62,7 +62,7 @@ def import_mirdip(apps, _schema_editor): "SPRYD3","hsa-miR-15a-5p",15,+9. 11060805626107E-001, "Cupid|MBStar|MirTar2|MultiMiTar|PACCMIT|bitargeting_May_2021|miRTar2GO|MirAncesTar|miranda_May_2021|mirbase|miRDB_v6|mirmap_May_2021|MiRNATIP|mirzag|TargetScan_v7_2", "V" """ parent_dir = pathlib.Path(__file__).parent.absolute().parent - mirdip_file_path = os.path.join(parent_dir, "files/mirDIP_Unidirectional_search_v.5.txt") + mirdip_file_path = os.path.join(parent_dir, "files/mirDIP_Unidirectional_search.txt") print("\nGetting Django models...") MirnaXGene = apps.get_model(app_label='modulector', model_name='MirnaXGene') diff --git a/modulector/migrations/0041_auto_20240410_1918.py b/modulector/migrations/0041_auto_20240410_1918.py new file mode 100644 index 0000000..1d72874 --- /dev/null +++ b/modulector/migrations/0041_auto_20240410_1918.py @@ -0,0 +1,48 @@ +# Generated by Django 4.2.11 on 2024-04-10 19:18 +import os +import pathlib +import pandas as pd +from django.db import migrations + + +def update_hmdd_v4(apps, schema_editor): + """ Update the version of the HMDD database to version 4.0 """ + MirnaDisease = apps.get_model('modulector', 'MirnaDisease') + + parent_dir = pathlib.Path(__file__).parent.absolute().parent + print(parent_dir) + file_path = os.path.join(parent_dir, "files/disease_hmdd.txt") + delimiter = "\t" + # loading files + data = pd.read_csv(filepath_or_buffer=file_path, + delimiter=delimiter, encoding="ISO-8859-1") + entities = [] + for index, row in data.iterrows(): + category, pmid, mirna, disease, description = row + # category is the Category codes assigned by the HMDD database to classify diseases + + # This line is in charge of capitalizing the R for the mirna, we must treat it as mature + # In the file are all lowercase, but in the website which provides said file, they + # are listed as mature. This will also maintain consistency from our side. + mirna = mirna.lower()[:6].lower() + mirna.lower()[6:].capitalize() + # correcting fields because the send quotes sometimes + disease = disease.replace("\"", "") + description = description.replace("\"", "") + mirna_disease = MirnaDisease(category=category, mirna=mirna, + disease=disease, pubmed_id=pmid, description=description) + entities.append(mirna_disease) + MirnaDisease.objects.all().delete() + MirnaDisease.objects.bulk_create(entities) + + assert MirnaDisease.objects.count() == data.shape[0] + + +class Migration(migrations.Migration): + + dependencies = [ + ('modulector', '0040_alter_mirnaxgene_gene_alter_mirnaxgene_score'), + ] + + operations = [ + migrations.RunPython(update_hmdd_v4), + ] diff --git a/modulector/processors/disease_processor.py b/modulector/processors/disease_processor.py deleted file mode 100644 index c50f22f..0000000 --- a/modulector/processors/disease_processor.py +++ /dev/null @@ -1,43 +0,0 @@ -import logging -import os -import pathlib -import sys - -import pandas as pd -from django.db import transaction, connection - -from modulector.models import MirnaDisease - -logger = logging.getLogger(__name__) -logger.addHandler(logging.StreamHandler(sys.stdout)) -logger.setLevel(logging.INFO) - - -def process(): - parent_dir = pathlib.Path(__file__).parent.absolute().parent - file_path = os.path.join(parent_dir, "files/disease.txt") - delimiter = "\t" - logger.info("loading disease info") - # loading files - data = pd.read_csv(filepath_or_buffer=file_path, - delimiter=delimiter, encoding="ISO-8859-1") - entities = [] - with transaction.atomic(): - logger.info("inserting data") - for index, row in data.iterrows(): - category, mirna, disease, pmid, description = row - - # This line is in charge of capitalizing the R for the mirna, we must treat it as mature - # In the file are all lowercase, but in the website which provides said file, they - # are listed as mature. This will also maintain consistency from our side. - mirna = mirna.lower()[:6].lower() + mirna.lower()[6:].capitalize() - # correcting fields because the send quotes sometimes - disease = disease.replace("\"", "") - description = description.replace("\"", "") - mirna_disease = MirnaDisease(category=category, mirna=mirna, - disease=disease, pubmed_id=pmid, description=description) - entities.append(mirna_disease) - with connection.cursor() as cursor: - cursor.execute("truncate table modulector_mirnadisease") - MirnaDisease.objects.bulk_create(entities) - logger.info("data inserted") diff --git a/modulector/tests/test_diseases.py b/modulector/tests/test_diseases.py index 91df0cf..28aeb44 100644 --- a/modulector/tests/test_diseases.py +++ b/modulector/tests/test_diseases.py @@ -11,19 +11,12 @@ def __check_empty_pagination(self, response): self.assertIsNone(response.data['next']) self.assertIsNone(response.data['previous']) - def __check_one_result_pagination(self, response): - """Checks if fields of response are valid for a one-result pagination response""" - self.assertEqual(response.data['count'], 1) - self.assertTrue(len(response.data['results']) == 1) - self.assertIsNone(response.data['next']) - self.assertIsNone(response.data['previous']) - def testDiseasesView(self): """ Test the disease endpoint for a valid mirna """ - response = client.get('/diseases/', {"mirna": "hsa-miR-9500"}) + response = client.get('/diseases/', {"mirna": "hsa-miR-6511b"}) self.assertEqual(response.status_code, 200) - self.__check_one_result_pagination(response) - self.assertEqual(response.data['count'], 1) + self.assertEqual(response.data['count'], 3) + self.assertTrue(len(response.data['results']) == 3) first_result = response.data['results'][0] self.assertTrue('id' in first_result) self.assertTrue('category' in first_result) From e8b7770ca62cb5ffdaa2f0e603a3486fac5193a1 Mon Sep 17 00:00:00 2001 From: mauricio Date: Wed, 10 Apr 2024 19:27:25 -0300 Subject: [PATCH 2/3] Update Documentation --- README.md | 28 +++++++++++++++++++++------- 1 file changed, 21 insertions(+), 7 deletions(-) diff --git a/README.md b/README.md index 77fbba9..48bf2a4 100644 --- a/README.md +++ b/README.md @@ -551,21 +551,35 @@ This service provides information, with evidence supported by experiments, on th - `pubmed`: URL to the scientific article in the Pubmed database where the evidence that relates miRNA to the disease is found. - `description`: Short description of why this miRNA is related to this disease. - Example: - - URL: + - URL: - Response: ```JSON { - "count":1, + "count":3, "next":null, "previous":null, "results":[ { - "id":3540992, - "category":"target gene", - "disease":"Liver Neoplasms", - "pubmed":"https://pubmed.ncbi.nlm.nih.gov/24658401", - "description":"The novel miR-9500 regulates the proliferation and migration of human lung cancer cells by targeting Akt1." + "id": 4203307, + "category": "other", + "disease": "Lymphoma", + "pubmed": "https://pubmed.ncbi.nlm.nih.gov/36248425", + "description": "LncHOTAIR/hsa-miR-6511b-5p/ATG7 could regulate the proliferation, apoptosis, and autophagy of Raji and BJAB lymphoma cells." + }, + { + "id": 4207900, + "category": "genetics_overexpression_promote", + "disease": "Colorectal Neoplasms", + "pubmed": "https://pubmed.ncbi.nlm.nih.gov/35590122", + "description": "In vitro, overexpression of miR-6511b-5p inhibited metastasis by decreasing CD44 expression via directly targeting BRG1 in colorectal cancer." + }, + { + "id": 4241262, + "category": "other", + "disease": "gastric adenocarcinoma", + "pubmed": "https://pubmed.ncbi.nlm.nih.gov/31772663", + "description": "2) were recognized as prognostic and used for the construction of a STAD prognostic signature." } ] } From 4be43be6f7af8f67a2202c98d19432d04c556cd8 Mon Sep 17 00:00:00 2001 From: mauricio Date: Wed, 10 Apr 2024 19:33:53 -0300 Subject: [PATCH 3/3] unnecesary files removed --- modulector/processors/mirdip_processor.py | 122 ---------------------- 1 file changed, 122 deletions(-) delete mode 100644 modulector/processors/mirdip_processor.py diff --git a/modulector/processors/mirdip_processor.py b/modulector/processors/mirdip_processor.py deleted file mode 100644 index 55b4d36..0000000 --- a/modulector/processors/mirdip_processor.py +++ /dev/null @@ -1,122 +0,0 @@ -import logging -import os -import pathlib -import sys -import time -from typing import List - -import pandas as pandas -from django.db import connection, transaction -from django.utils.timezone import make_aware - -from modulector.mappers import pubmed_mapper -from modulector.models import MirnaSource, MirnaXGene, Mirna, Pubmed - -# TODO: remove fixed data. - -logger = logging.getLogger(__name__) -logger.addHandler(logging.StreamHandler(sys.stdout)) -logger.setLevel(logging.INFO) - -parent_dir = pathlib.Path(__file__).parent.absolute().parent - -mirna_dict = {} - - -def process(): - """file - This functions process the data from I2D and loads the - mirna gene table - """ - mirna_source = MirnaSource.objects.first() - # Do to the size of this file, you should download it from the release files section. It is not in the repo. - file_path = os.path.join(parent_dir, "files/mirdip.txt") - logger.info("loading data for i2d") - # loading files - series_names = mirna_source.mirnacolumns.order_by('position').values_list('field_to_map', flat=True) - columns_to_use = mirna_source.mirnacolumns.order_by('position').values_list('position', flat=True) - series_names = list(series_names) - # insertion templates main - table_name = MirnaXGene._meta.db_table - insert_query_prefix = f'INSERT INTO {table_name} (gene, score, mirna_source_id, mirna_id, sources,score_class) VALUES ' - insert_template = "('{}', {}, {}, {}, '{}', '{}')" - - # insertion templates pubmeds - table_name_pubmed = Pubmed._meta.db_table - insert_query_pubmed_prefix = f'INSERT INTO {table_name_pubmed} (pubmed_id, pubmed_url, gene, mirna_code) VALUES ' - insert_template_pubmed = "({},'{}','{}','{}')" - - # delete table - with transaction.atomic(): - with connection.cursor() as cursor: - delete_query = f'delete from {table_name} where mirna_source_id = {mirna_source.id}' - cursor.execute(delete_query) - delete_query = f'truncate table {table_name_pubmed} ' - cursor.execute(delete_query) - - with pandas.read_csv(filepath_or_buffer=file_path, - delimiter=mirna_source.file_separator, - names=series_names, usecols=columns_to_use, chunksize=500000) as reader: - - for chunk in reader: - start = time.time() - logger.info("grouping data of chunk") - filtered_data = chunk[chunk["MIRNA"].str.contains("hsa")] - with transaction.atomic(): - logger.info("inserting chunk") - insert_statements: List[str] = [] - for row in filtered_data.iterrows(): - gene, mirna_code, score, source_name, score_class = row[1] - mirna_obj = get_or_create_mirna(mirna_code) - mirna_id: int = mirna_obj.pk - # Generating tuples for insertion - insert_statements.append( - insert_template.format(gene, score, mirna_source.id, mirna_id, source_name, score_class)) - # inserting data - insert_query = insert_query_prefix + ','.join(insert_statements) - insert_statements.clear() - if insert_query_prefix == insert_query: - continue - with connection.cursor() as cursor: - cursor.execute(insert_query) - print('chunk processing took: ') - end = time.time() - print("%0.2f" % ((end - start) / 60)) - - logger.info("finding pubmeds") - - pubmed_data = pubmed_mapper.execute() - pubmed_list = pubmed_mapper.build_pubmed_list(pubmed_data) - - logger.info("saving pubmeds") - if len(pubmed_list) != 0: - insert_statements_pubmed: List[str] = [] - for pubmed_dto in pubmed_list: - insert_statements_pubmed.append( - insert_template_pubmed.format(pubmed_dto.pubmed_id, pubmed_dto.pubmed_url, - pubmed_dto.gene, pubmed_dto.mirna)) - with transaction.atomic(): - with connection.cursor() as cursor: - insert_query_pubmed = insert_query_pubmed_prefix + ','.join(insert_statements_pubmed) - cursor.execute(insert_query_pubmed) - - logger.info("insertion finished - synchronizing source") - mirna_source.synchronization_date = make_aware(mirna_source.synchronization_date.now()) - mirna_source.save() - - -def get_or_create_mirna(mirna_code): - """ - This method receives a mirna code and created the mirna if necessary - Otherwise will return the object from the database - """ - if mirna_code in mirna_dict: - return mirna_dict.get(mirna_code) - mirna_in_db = Mirna.objects.filter(mirna_code=mirna_code) - if not mirna_in_db.exists(): - mirna_obj = Mirna(mirna_code=mirna_code) - mirna_obj.save() - else: - mirna_obj = mirna_in_db.get() - mirna_dict[mirna_code] = mirna_obj - return mirna_obj